bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic Handgrip Exercise: Feasibility and Physiologic Stress Response of a Potential Needle-Free Cardiac Magnetic Resonance Stress Test
Authors: Ochs Andreas , Nippes Michael , Salatzki Janek , Weberling Lukas D. , Riffel Johannes , Müller-Hennessen Matthias , Giannitsis Evangelos , Osman Nael , Stehning Christian , André Florian , Katus Hugo A. , Frey Norbert , Friedrich Matthias G. , Ochs Marco M. 
Published: December 2021

Background: Cardiac magnetic resonance (CMR) pharmacological stress-testing is a well-established technique for detecting myocardial ischemia. Although stressors and contrast agents seem relatively safe, contraindications and side effects must be considered. Substantial costs are further limiting its applicability. Dynamic handgrip exercise (DHE) may have the potential to address these shortcomings as a physiological stressor. We therefore evaluated the feasibility and physiologic stress response of DHE in relation to pharmacological dobutamine-stimulation within the context of CMR examinations.Methods: Two groups were prospectively enrolled: (I) volunteers without relevant disease and (II) patients with known CAD referred for stress-testing. A both-handed, metronome-guided DHE was performed over 2 min continuously with 80 contractions/minute by all participants, whereas dobutamine stress-testing was only performed in group (II). Short axis strain by fast-Strain-ENCoded imaging was acquired at rest, immediately after DHE and during dobutamine infusion.Results: Eighty middle-aged individuals (age 56 ± 17 years, 48 men) were enrolled. DHE triggered significant positive chronotropic (HRrest: 68 ± 10 bpm, HRDHE: 91 ± 13 bpm, p &lt; 0.001) and inotropic stress response (GLSrest: −19.4 ± 1.9%, GLSDHE: −20.6 ± 2.1%, p &lt; 0.001). Exercise-induced increase of longitudinal strain was present in healthy volunteers and patients with CAD to the same extent, but in general more pronounced in the midventricular and apical layers (p &lt; 0.01). DHE was aborted by a minor portion (7%) due to peripheral fatigue. The inotropic effect of DHE appears to be non-inferior to intermediate dobutamine-stimulation (GLSDHE= −19.5 ± 2.3%, GLSDob= −19.1 ± 3.1%, p = n.s.), whereas its chronotropic effect was superior (HRDHE= 89 ± 14 bpm, HRDob= 78 ± 15 bpm, p &lt; 0.001).Conclusions: DHE causes positive ino- and chronotropic effects superior to intermediate dobutamine-stimulation, suggesting a relevant increase of myocardial oxygen demand. DHE appears to be safe and timesaving with broad applicability. The data encourages further studies to determine its potential to detect obstructive CAD.
Association Between Dynamic Change of QT Interval and Long-Term Cardiovascular Outcomes: A Prospective Cohort Study
Authors: Ye Min , Zhang Jing-Wei , Liu Jia , Zhang Ming , Yao Feng-Juan , Cheng Yun-Jiu 
Published: December 2021

Background: The prolongation or shortening of heart rate-corrected QT (QTc) predisposes patients to fatal ventricular arrhythmias and sudden cardiac death (SCD), but the association of dynamic change of QTc interval with mortality in the general population remains unclear.Methods: A total of 11,798 middle-aged subjects from the prospective, population-based cohort were included in this analysis. The QTc interval corrected for heart rate was measured on two occasions around 3 years apart in the Atherosclerosis Risk in Communities (ARIC) study. The ΔQTc interval was calculated by evaluating a change in QTc interval from visit 1 to visit 2.Results: After a median follow-up of 19.5 years, the association between the dynamic change of QTc interval and endpoints of death was U-shaped. The multivariate-adjusted hazard ratios (HRs) comparing subjects above the 95th percentile of Framingham–corrected ΔQTc (ΔQTcF) (≥32 ms) with subjects in the middle quintile (0–8 ms) were 2.69 (95% CI, 1.68–4.30) for SCD, 2.51 (1.68–3.74) for coronary heart disease death, 2.10 (1.50–2.94) for cardiovascular death, and 1.30 (1.11–1.55) for death from any cause. The corresponding HRs comparing subjects with a ΔQTcF below the fifth percentile (&lt;-23 ms) with those in the middle quintile were 1.82 (1.09–3.05) for SCD, 1.83 (1.19–2.81) for coronary heart disease death, 2.14 (1.51–2.96) for cardiovascular death, and 1.31 (1.11–1.56) for death from any cause. Less extreme deviations of ΔQTcF were also associated with an increased risk of death. Similar, albeit weaker associations also were observed with ΔQTc corrected with Bazett's formula.Conclusions: A dynamic change of QTc interval is associated with increased mortality risk in the general population, indicating that repeated measurements of the QTc interval may be available to provide additional prognostic information.
Prognostic Significance of Feature-Tracking Right Ventricular Global Longitudinal Strain in Non-ischemic Dilated Cardiomyopathy
Authors: Cittar Marco , Cipriani Alberto , Merlo Marco , Vitrella Giancarlo , Masè Marco , Carrer Anna , Barbati Giulia , Belgrano Manuel , Pagnan Lorenzo , De Lazzari Manuel , Giorgi Benedetta , Cova Maria A. , Iliceto Sabino , Basso Cristina , Stolfo Davide , Sinagra Gianfranco , Perazzolo Marra Martina 
Published: December 2021

Aims: Left ventricular global longitudinal strain (GLS) by cardiac magnetic resonance feature tracking (CMR-FT) analysis has shown an incremental prognostic value compared to classical parameters in non-ischemic dilated cardiomyopathy (NICM). However, less is known about the role of right ventricular (RV) GLS. Our objective was to evaluate the prognostic impact of RV-GLS by CMR-FT analysis in a population of NICM patients.Methods: In this multicenter study, we examined NICM patients evaluated with a comprehensive CMR-FT study. Major cardiac events (MACEs) were considered as the study primary outcome measure and were defined as a composite of (a) cardiovascular death, (b) cardiac transplant or destination therapy ventricular assist device, (c) hospitalization for life-threatening ventricular arrhythmias or implantable cardiac defibrillator appropriate intervention. Heart failure (HF) related events, including hospitalizations and life-threatening arrhythmia-related events were considered as secondary end-points. Receiver operating time-dependent analysis were used to calculate the possible additional effect of RV-GLS to standard evaluation.Results: We consecutively enrolled 273 patients. During a median follow-up of 39 months, 41 patients (15%) experienced MACEs. RV-GLS and LV late gadolinium emerged as the strongest prognostic CMR-FT variables: their association provided an estimated 3-year MACEs rate of 29%. The addition of RV-GLS significantly improved the prognostic accuracy in predicting MACEs with respect to the standard evaluation including LGE (areas under the curve from 0.71 [0.66–0.82] to 0.76 [0.66–0.86], p = 0.03). On competing risk analysis, RV-GLS showed a significant ability to reclassify overall both HF-related and life-threatening arrhythmia-related events, regardless of LV and RV ejection fraction.Conclusions: In NICM patients, RV-GLS showed a significant prognostic role in reclassifying the risk of MACEs, incremental with respect to standard evaluation with standard prognostic parameters.
Atrial Fibrillation Ablation Using Robotic Magnetic Navigation Reduces the Incidence of Silent Cerebral Embolism
Authors: Zheng Jie , Wang Meng , Tang Qun-feng , Xue Feng , Li Ku-lin , Dang Shi-peng , Liu Xiao-yu , Zhao Xiao-xi , Zhang Chang-ying , Yu Zhi-ming , Han Bing , Jiang Ting-bo , Yao Yan , Wang Ru-Xing 
Published: December 2021

Background: The incidence of silent cerebral embolisms (SCEs) has been documented after pulmonary vein isolation using different ablation technologies; however, it is unreported in patients undergoing with atrial fibrillation (AF) ablation using Robotic Magnetic Navigation (RMN). The purpose of this prospective study was to investigate the incidence, risk predictors and probable mechanisms of SCEs in patients with AF ablation and the potential impact of RMN on SCE rates.Methods and Results: We performed a prospective study of 166 patients with paroxysmal or persistent AF who underwent pulmonary vein isolation. Patients were divided into RMN group (n = 104) and manual control (MC) group (n = 62), and analyzed for their demographic, medical, echocardiographic, and risk predictors of SCEs. All patients underwent cerebral magnetic resonance imaging within 48 h before and after the ablation procedure to assess cerebral embolism. The incidence and potential risk factors of SCEs were compared between the two groups. There were 26 total cases of SCEs in this study, including 6 cases in the RMN group and 20 cases in the MC group. The incidences of SCEs in the RMN group and the MC group were 5.77 and 32.26%, respectively (X2 = 20.63 P &lt; 0.05). Univariate logistic regression analysis demonstrated that ablation technology, CHA2DS2-VASc score, history of cerebrovascular accident/transient ischemic attack, and low ejection fraction were significantly associated with SCEs, and multivariate logistic regression analysis showed that MC ablation was the only independent risk factor of SCEs after an AF ablation procedure.Conclusions: Ablation technology, CHA2DS2-VASc score, history of cerebrovascular accident/transient ischemic attack, and low ejection fraction are associated with SCEs. However, ablation technology is the only independent risk factor of SCEs and RMN can significantly reduce the incidence of SCEs resulting from AF ablation.Clinical Trial Registration: ChiCTR2100046505.
Wind Speed Forecasting in Fishing Harbor Anchorage Using a Novel Deep Convolutional Neural Network
Authors: He Caifen , Chen Qiaote , Fang Xuyuan , Zhou Yangzhang , Fu Randi , Jin Wei 
Published: December 2021

Wind speed forecasting is an important issue in Marine fisheries. Improving the accuracy of wind speed forecasting is helpful to reduce the loss of fishery economy caused by strong wind. This paper proposes a wind speed forecasting method for fishing harbor anchorage based on a novel deep convolutional neural network. By combining the actual monitoring data of the automatic weather station with the numerical weather prediction (NWP) products, the proposed method constructing a deep convolutional neural network was based wind speed forecasting model. The model includes a one-dimensional convolution module (1D-CM) and a two-dimensional convolution module (2D-CM), in which 1D-CM extracts the time series features of the meteorological data, and 2D-CM is used to mine the latent semantic information from the outputs of 1D-CM. In order to alleviate the overfitting problem of the model, the L2 regularization and the dropout strategies are adopted in the training process, which improves the generalization of the model with higher reliability for wind speed prediction. Simulation experiments were carried out, using the 2016 wind speed and related meteorological data of a sheltered anchorage in Xiangshan, Ningbo, China. The results showed that, for wind speed forecast in the next 1 h, the proposed method outperform the traditional methods in terms of prediction accuracy; the mean absolute error (MAE) and the mean absolute percentage error (MAPE) of the proposed method are 0.3945 m/s and 5.71%, respectively.
Characterization of Full Pore and Stress Compression Response of Reservoirs With Different Coal Ranks
Authors: Lu Jielin , Fu Xuehai , Kang Junqiang , Cheng Ming , Wang Zhenzhi 
Published: December 2021

The accurate characterization of coal pore structure is significant for coalbed methane (CBM) development. The splicing of practical pore ranges of multiple test methods can reflect pore structure characteristics. The pore\fracture compressibility is the main parameter affecting the porosity and permeability of coal reservoirs. The difference in compressibility of different coal rank reservoirs and pore\fracture structures with changing stress have not been systematically found. The pore structure characteristics of different rank coal samples were characterized using the optimal pore ranges of high-pressure mercury intrusion (HPMI), low-temperature liquid nitrogen adsorption (LT-N2A), low-pressure carbon dioxide adsorption (LP-CDA), and nuclear magnetic resonance (NMR) based on six groups of different rank coal samples. The compressibility of coal matrix and pore\fracture were studied using HPMI data and NMR T2 spectrum under effective stress. The results show that the more accurate full pore characterization results can be obtained by selecting the optimal pore range measured by HPMI, LT-N2A, and LP-CDA and comparing it with the NMR pore results. The matrix compressibility of different rank coal samples shows that low-rank coal &gt; high-rank coal &gt; medium-rank coal. When the effective stress is less than 6 MPa, the microfractures are compressed rapidly, and the compressibility decreases slowly when the effective stress is more than 6 MPa. Thus, the compressibility of the adsorption pore is weak. Nevertheless, the adsorption pore has the most significant compression space because of the largest proportion in different pore structures. The variation trend of matrix compressibility and pore\fracture compressibility is consistent with the increase of coal rank. The compressibility decreases with the rise of reservoir heterogeneity and mechanical strength. The development of pore volume promotes compressibility. The research results have guiding significance for the exploration and development of CBM in different coal rank reservoirs.
RETRACTED: Effect of Weekly Long-Acting Growth Hormone Replacement Therapy Compared to Daily Growth Hormone on Children With Short Stature: A Meta-Analysis
Authors: Ma Liyan , Li Liangyi , Pan Wen , Huang Congfu , Liu Limei , Zhang Xiaoxiao 
Published: December 2021

BackgroundWe performed a meta-analysis to evaluate the efficacy and safety of weekly long-acting growth hormone replacement therapy compared to daily growth hormone in children with short stature.MethodsA systematic literature search up to April 2021 was performed and 11 studies included 1,232 children with short stature treated with growth hormone replacement therapy at the start of the study; 737 of them were using weekly long-acting growth hormone replacement therapy and 495 were using daily growth hormone. They were reporting relationships between the efficacy and safety of long-acting growth hormone replacement therapy and daily growth hormone in children with short stature. We calculated the odds ratio (OR), and mean difference (MD) with 95% confidence intervals (CIs) to assess the efficacy and safety of weekly long-acting growth hormone replacement therapy compared to daily growth hormone in children with short stature using the dichotomous or continuous method with a random or fixed-effect model.ResultsLong-acting growth hormone replacement therapy had significantly lower height standard deviation scores chronological age (MD, −0.10; 95% CI, −0.13 to −0.08, p &lt;0.001), and insulin-like growth factor binding protein-3 (MD, −0.69; 95% CI, −1.09 to −0.30, p &lt;0.001) compared to daily growth hormone in children with short stature.However, growth hormone replacement therapy had no significantly difference in height velocity (MD, −0.09; 95% CI, −0.69–0.5, p = 0.76), height standard deviation scores bone age (MD, −0.04; 95% CI, −0.10–0.02, p = 0.16), insulin-like growth factor 1 standard deviation scores (MD, 0.26; 95% CI, −0.26–0.79, p = 0.33), and incidence of adverse events (OR, 1.16; 95% CI, 0.90–1.50, p = 0.25) compared to daily growth hormone in children with short stature.ConclusionsLong-acting growth hormone replacement therapy had significantly lower height standard deviation scores chronological age, and insulin-like growth factor binding protein-3 compared to daily growth hormone in children with short stature. However, growth hormone replacement therapy had no significant difference in height velocity, height standard deviation scores bone age, insulin-like growth factor 1 standard deviation scores, and incidence of adverse events compared to daily growth hormone in children with short stature. Further studies are required to validate these findings.
The Importance of Nodule Size in the Management of Ruptured Thyroid Nodule After Radiofrequency Ablation: A Retrospective Study and Literature Review
Authors: Chen Wen-Chieh , Luo Sheng-Dean , Chen Wei-Chih , Chou Chen-Kai , Chang Yen-Hsiang , Cheng Kai-Lun , Lin Wei-Che 
Published: December 2021

BackgroundNodule rupture is a relatively uncommon yet severe complication of radiofrequency ablation (RFA). When nodule rupture occurs, determining suitable therapeutic management is a critical issue. A study herein aimed to identify the predictive factors affecting the management of post-RFA nodule rupture.MethodsPost-RFA nodule rupture data of 9 patients were enrolled from 2 medical centers. A literature investigation was performed, uncovering nodule rupture data of 17 patients. A total of 26 patients were analyzed and divided into two groups, categorized as patients requiring either invasive or conservative therapeutic management. Data including initial symptoms, imaging, therapeutic management, and prognosis were reviewed and compared between the two groups.ResultsSignificant differences in nodule diameter, and the ablation time of the course prior to rupture (RUP time) were noted between the two groups (p = 0.045 and 0.008, respectively). Logistic regression analysis indicated the initial nodule diameter and RUP time significantly affected the requirement of invasive treatment (OR 1.99 and 1.11, respectively). Considering practicality, when a nodule with an initial maximum diameter of &gt;4.5cm ruptured, invasive management was suggested (sensitivity 69% and specificity 79%).ConclusionThough nodule ruptures can be managed conservatively, a ruptured nodule with an initial maximum diameter of &gt;4.5cm may require invasive management. Understanding the significant clinical and imaging features will help physicians make an appropriate risk assessment to determine the correct treatment in a timely manner.
Diabetes Care in French Guiana: The Gap Between National Guidelines and Reality
Authors: Sudre Christine , Duplan Hélène , Bukasakakamba John , Nacher Mathieu , Peyre-Costa Pascale , Sabbah Nadia 
Published: December 2021

IntroductionFrench Guiana is a multicultural overseas territory in the Amazon, where precariousness and difficulties in access to care are widespread. The prevalence of diabetes is double that of other French departments, and cardiovascular morbidity and mortality is high. The objective of the study was to analyze the biological, clinical and therapeutic follow-up of patients with diabetes mellitus using exhaustive data and to correlate it with national and European recommendations.Material and MethodsUsing the national health insurance data, 9079 and 10075 patients with diabetes mellitus were analyzed in 2018 and 2019, respectively. We analyzed antidiabetic treatments, medical, dental, and podiatric consultations, examinations prescribed as part of the annual follow-up, and home nursing care.ResultsThere was a significant increase over one year in the number of patients (+10%) with diabetes, mainly women (60%), and 31% were under 54 years of age, with a disparity depending on the area of the territory, the most isolated having less access to screening. Less than 56% of patients had HbA1c measurements twice a year, less than 43% had an annual renal check-up, only 19% had an ophthalmic check-up at least every two years, less than 25% had an annual dental check-up, and less than 4% had an annual follow-up with the podiatrist.ConclusionsSubstandard diabetes monitoring is a major problem likely to increase morbidity and mortality. Adapting health care to the specificities of the territory is crucial, notably by formalizing the delegation of care to advanced practice nurse and non-healthcare professionals in precarious or geographically isolated areas.
Polyacrylonitrile/Crown Ether Composite Nanofibres With High Efficiency for Adsorbing Li(I): Experiments and Theoretical Calculations
Authors: Ding Tao , Wu Qian , Zheng Mianping , Nie Zhen , Li Min , Peng Suping , Wang Yunsheng , Yu Xudong , Qian Cheng , Tang Si , Wang Mingliang 
Published: December 2021

Lithium, as the lightest alkali metal, is widely used in military and new energy applications. With the rapid growth in demand for lithium resources, it has become necessary to improve the effectiveness of extraction thereof. By using chemical grafting and electrospinning techniques, nanofibres containing crown ether were developed for adsorbing Li(I) from the brine in salt lakes, so as to selectively adsorb Li(I) on the premise of retaining specific vacancies of epoxy groups in crown ether. In lithium-containing solution, the adsorbing materials can reach adsorption equilibrium within three hours, and the maximum adsorption capacity is 4.8 mg g−1. The adsorption mechanisms of the adsorbing materials for Li(I) were revealed by combining Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS) with density functional theory (DFT) calculation. The results indicated that in crown ether, O in epoxy groups was coordinated with Li(I) to form Li–O and four O atoms in the epoxy groups were used as electron donors. After coordination, two O atoms protruded from the plane and formed a tetrahedral structure with Li(I), realising the specific capture of Li(I). By desorbing fibres that adsorbed Li(I) with 0.5-M HCl, the adsorption capacity only decreased by 10.4% after five cycles, proving ability to regenerate such materials. The nanofibres containing crown ether synthesised by chemical grafting and electrospinning have the potential to be used in extracting lithium resources from the brine in salt lakes.
Farmyard Manure as K-Fertilizer Modulates Soil Biological Activities and Yield of Wheat Using the Integrated Fertilization Approach
Authors: Kumar Sanjeev , Dhar Shiva , Barthakur Sharmistha , Rajawat Mahendra Vikram Singh , Kochewad S. A. , Kumar Sudhir , Kumar Dileep , Meena L. R. 
Published: December 2021

Potassium fertilization is often ignored by assuming alluvial soils have sufficient K reserves in the North West Plain Zone of India under cereal-based cropping systems. There is scanty information on the impact of integrated K fertilization on soil enzymes, nutrients availability, microbial population, and wheat yield cultivated in the corn–wheat cropping system. The current study exhibits that treatment (T7) applied with a dose of 90 kg K ha−1[30 kg K by farmyard manure (FYM) and 60 kg K by muriate of potash (MOP)] significantly enhances the various microbial populations from 48.00 to 123.10% and 39.00 to 124.00%, soil enzymatic activities from 70.31 to 180.00% and 102.42 to 175.68%, and available nutrients from 2.43 to 8.44% and 14.79 to 22.87% for the first and second years of wheat cultivation, respectively. It also improved various yield parameters (12.39–41.71% and 18.24–41.14%) during both the consecutive years of cultivation. Statistical analyses revealed that the treatments (T4, T5,and T7) applied with integrated fertilization of wheat cultivation through FYM and MOP were more promising for improving soil enzymatic activities (11.59–57.22%), microbial populations (5.14–15.70%), available nutrients in soil (7.60–16.54%), and crop yield (1.06–5.85%) during the second year of cultivation as compared to the first year of cultivation. This study might be helpful to reclaim soil health and reduce chemical fertilizers used in agricultural lands.