bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanozyme‐Engineered Hyaluronic Acid Adhesives Loading Platelet‐Rich Plasma for Multilayered Osteoarthritis Treatment with Pain‐Relief Effect
Authors: Zhao Yiyang , Duan Wanglin , Zhu Bin , Chen Yurong , Zhu Ye , Martin‐Saldaña Sergio , Xiao Zhengtao , Liu Xinyi , Feng Luyao , Ren Yiming , Gong Yining , Huo Fuquan , Li Jinqing , Bu Yazhong , Du Baoji , Zhang Lining 
Published: December 2024

AbstractOsteoarthritis (OA) is the most common degenerative joint disease, causing pain, disability, and economic strain. Combining nanozymes with dopamine (DOPA)‐based adhesives offers a promising approach to effectively modulate the microenvironment of OA‐affected tissues. However, traditional fabrication methods of DOPA‐based adhesives often involve external oxidants or curing agents, which can introduce additional oxidative stress, posing systemic risks. Here, the different enzyme‐catalyzed activities of platinum–copper (PtCu) nanozymes at different pH values are utilized to directly catalyze the cross‐linking of DOPA‐modified hyaluronic acid (HAD), representing a new polymerization method for phenol‐based bioadhesives. The resulting adhesive (HAD/PtCu/platelet‐rich plasma (PRP)), when combined with PRP, effectively mitigates the generation of proinflammatory factors, scavenges reactive oxygen species, boosts the hypoxic chemotaxis of chondrocytes, stimulates chondrocyte proliferation and migration, and protects interleukin‐1β‐treated human articular chondrocyte C28/I2 cells from further OA advancement. Additionally, in vivo assessments show that HAD/PtCu/PRP significantly alleviates pain and improves the knee microenvironment in osteoarthritic rats. These findings suggest that HAD/PtCu/PRP provides a promising alternative in OA therapy.
Hierarchically Porous Carbon Colloidal Aerogels for Highly Efficient Flow Cells
Authors: Hou Yinglai , Sheng Zhizhi , Zhang Mengchuang , Lin Kaifa , Kong Jie , Zhang Xuetong 
Published: December 2024

AbstractElectrodes with high active areas often compromise with limited ion transport kinetics in flow electrochemical devices. Herein, hierarchically porous carbon colloidal aerogels (HPCCAs) are constructed with multiscale porosities to meet the tradeoff between highly active areas and efficient mass transfer behavior. It is realized by introducing multiphase co‐separation in a sol‐gel transition process of aramid nanofibers/polyvinylpyrrolidone/carbon nanotubes followed by subsequent freeze‐drying and carbonization. The resulting HPCCA possesses a high volumetric electrochemically accessible surface area (3.27 × 107 m−1) and excellent mass transfer efficiency, 2–3 times higher permeability than commercial Toray carbon paper and 9.86 times higher than bare aerogel. An all‐vanadium single cell with HPCCAs as electrodes possesses a high energy efficiency of 83.18% under the current density of 100 mA cm−2, which is 10–31% higher than most of the state‐of‐the‐art carbon electrode materials including commercial carbon papers. In addition, the cell with HPCCAs shows outstanding long‐term stability up to 1000 cycles. Notably, HPCCAs are applicable to more flow battery systems, such as iron/chromium (Fe/Cr), iron/vanadium (Fe/V), zinc/bromine (Zn/Br), vanadium/methylene blue (V/MB), sodium salt of flavin mononucleotide/potassium ferrocyanide (FMN‐Na/K4[Fe(CN)6]), and methyl viologen/4‐hydroxy‐2,2,6,6‐tetramethyl‐piperidin‐1‐oxyl (MV/4‐HO‐TEMPO). This work offers a new chemistry paradigm for developing advanced nanoporous aerogel materials and paves the way toward highly efficient flow electrochemical devices.
Protic Ionic Liquids: A General Strategy for Enhancing Electrical Conductivity and Stretchability of Conducting Polymer Thin Films
Authors: Kim Kyungjin , Han Minwoo , Ahn Hyungju , Kim Minji , Noh Jiyun , Noh Eunseo , Choi Haemin , Lee Seoung Ho , Lee Byoung Hoon 
Published: December 2024

AbstractIonic liquids (ILs) are promising materials for enhancing the electrical conductivity and stretchability of poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS)‐based stretchable transparent conductors. However, the relationship between the chemical structures of ILs and the electrical and mechanical properties of PEDOT:PSS/IL composites remains unclear. In this study, the impact of protic ILs (p‐ILs) on the electrical conductivity and stretchability of PEDOT:PSS/IL thin films is investigated via a comparative analysis with aprotic ILs (ap‐ILs). By synthesizing a series of p‐ILs and ap‐ILs based on imidazolium (IM) and bis(trifluoromethanesulfonyl)imide ions, it is demonstrated that p‐ILs significantly enhance electrical conductivity and stretchability, outperforming ap‐ILs. In addition, these properties further improve with decreasing alkyl chain length of IM cations, achieving maximum electrical conductivity and stretchability of ≈2200 S cm−1 and 65%, respectively. Notably, the crystalline structures of PEDOT:PSS/IL thin films are elucidated, revealing that p‐ILs with shorter alkyl chains facilitate the formation of PSS crystallites due to hydrogen bonding between p‐ILs and PSS, which in turn enhance electrical conductivity and stretchability. Leveraging these insights, PEDOT:PSS/p‐IL‐based strain sensors with broad dynamic ranges and tunable gauge factors are developed. The findings of this study provide valuable design guidelines for developing high‐performance ILs in stretchable and wearable electronics.
Thermal Transfer Printed Flexible and Wearable Bionic Skin with Bilayer Nanofiber for Comfortable Multimodal Health Management
Authors: Liang Xinshuo , Meng Shuo , Zhi Chuanwei , Zhang Shuai , Tan Renjie , Xu Xingyuan , Huang Kaisong , Lei Leqi , Hu Jinlian 
Published: December 2024

AbstractThe advent of bionic skin sensors represents a significant leap forward in the realm of wearable health monitoring technologies. Existing bionic skin technologies face several limitations, including complex and expensive manufacturing processes, low wearing comfort, and challenges in achieving comfortable real‐time health monitoring. These shortcomings hinder the widespread adoption and practical utility of bionic skin in various applications. The bionic skin invention presented in this article addresses these issues by introducing a novel thermal transfer manufacturing process that is low‐cost and easy to operate. This method is particularly suitable for the small‐scale mass production required for bionic skin applications. Additionally, the innovative bilayer unidirectional moisture transport nanomembrane incorporated into the bionic skin offers high extensibility and breathability. This feature enhances the ability of the skin to absorb sweat, thereby facilitating comfortable real‐time health monitoring. The specially designed bionic skin sensor embedded within this system can monitor various biomarkers in sweat, including glucose, lactic acid, uric acid, pH, temperature, and skin impedance. When combined with the CARE(Continuous Analyte Monitoring with Real‐time Engagement) system, it enables real‐time data transmission and processing, offering a comprehensive approach to health monitoring that is both comfortable and reliable.
Ionic Diode‐Based Drug Delivery System
Authors: Yoo Hyunjae , Kang Soon‐Bo , Kim Jeongsoo , Cho Wonkyung , Ha Hyojeong , Oh Seyoung , Jeong Seol‐Ha , Lee Sihwan , Lee Hyemin , Park Chang Seo , Lee Dong‐yup , Chung Taek Dong , Lee Kyung‐Mi , Sun Jeong‐Yun 
Published: December 2024

AbstractDrug delivery systems hold promise for delivering cytotoxic drugs by controlling the timing and location of the drug release. However, conventional delivery mechanisms often fall short of achieving spatiotemporally controlled yet sustained release, which is crucial for ensuring drug efficacy and minimizing impact on surrounding tissues. Here, an ionic diode‐based drug delivery system is reported that is controlled by an electric potential and capable of releasing drugs at scales ranging from nanogram to microgram. The migrated drug is slowly but continuously diffused to the lesion through the hydrogel at the desired rate. The ionic diode provides flow‐free drug delivery while minimizing unintended drug leakage over prolonged periods. Implanted in a freely moving tumor‐bearing mouse model, the system filled with doxorubicin demonstrated superior anti‐tumor efficacy and minimal off‐target immune toxicity compared to the intratumoral injection of free doxorubicin. With its mechanically compliant and biocompatible components, the system offers a safe and readily translatable approach to patients with surgically unresectable tumors.
Self‐Wrinkling‐Induced Mechanically Adaptive Patterned Surface of Photocuring Coating for Abrasion Resistance
Authors: Zhu Yi , Li Jin , Ma Tianjiao , Gao Xiaxin , Li Kexing , Ma Xiaodong , Jiang Xuesong 
Published: December 2024

AbstractProviding mechanically adaptive performance to surfaces is significant in preserving materials from damage in variable environments, however, it has rarely been studied. Inspired by the mechanically adaptive behaviors of the surface microstructure on the carapace of desert scorpions and bark of desert tamarisks, a self‐wrinkled mechanically adaptive patterned surface (SWMAPS) using one‐step UV‐curing and self‐wrinkling technique is reported. Because of the fluorinated polyurethane photo‐initiator formed by self‐assembly at the top surface, UV‐induced photo‐crosslinking can spontaneously generate a gradient‐crosslinked structure and wrinkled patterns with different morphology. With mechanically adaptive behavior originating from self‐assembled fluorinated polyurethane photo‐initiators, gradient‐crosslinked structures, and self‐wrinkled patterns, the SWMAPS remains intact under 600 cycles of reciprocating friction with little variation in the coefficient of friction and water contact angle. The SWMAPS prepared by programmable UV irradiation maintains integral under 1800 cycles of reciprocating friction with a stable friction coefficient. Furthermore, the SWMAPS is fabricated with high efficiency, regulated morphology, good surface mechanical properties, and self‐recovery performance. This strategy establishes a new field of mechanically adaptive patterned surfaces, which significantly improves durability and prolongs the service life of materials in variable environments.
Role of Electronic Conductivities Toward Practical All‐Solid‐State Lithium‐Metal/Sulfur Batteries
Authors: Ahmad Niaz , Fan Cailing , Faheem Muhammad , Zeng Chaoyuan , Mahmood Sajid , Liang Xiaoxiao , Yu Xianzhe , Dong Qinxi , Yang Wen 
Published: December 2024

AbstractInorganic solid‐state electrolytes (ISSEs) are recognized as promising candidates for safer and higher energy‐density all‐solid‐state lithium‐metal/sulfur batteries (ASSLM/SBs). Significant efforts have been directed at designing ISSEs with better chemical/electrochemical stability, superior lithium‐ion conductivity, and extensive working voltage windows. However, it has been investigated that Li‐dendrites produced within bulk ISSEs during the charge‐discharge process short‐circuit ASSLM/SBs. Notably, non‐negligble electronic conductivity (σe) ≈10−8 S cm−1 can trigger nucleation of Li‐dendrites at intrinsic defects, e.g., grain boundaries, pores, and cracks of ISSEs, leading to a significant self‐discharge phenomenon in ASSLM/SBs. Furthermore, the reasons behind the insufficient utilization of cathode active materials (CAMs) in ASSLM/SBs at practical current densities or C‐rate remained overlooked. Herein, first, the strategies to reduce the σe of sulfide‐based SSEs to prevent the Li‐dendrite formation at intrinsic defects are discussed. Second, strategies to enhance sulfur‐based cathodes' ionic and electronic conductivity (CAMs: Li2S and S8) are addressed. How a balanced ionic and electronic conductivity in the positive cathode layer realizes fast kinetics and maximizes the utilization of CAMs and reversibility for high‐performance ASSLM/SBs is also discussed. Finally, an extensive conclusion and innovative perspectives are presented to give readers a clearer insight into ASSLM/SBs.
Pyruvate Kinase M2‐Responsive Release of Paclitaxel and Indoleamine 2,3‐Dioxygenase Inhibitor for Immuno‐Chemotherapy of Nonsmall Cell Lung Cancer
Authors: Wu Haisi , Sun Xianbao , Li Kaiming , Li Jinyu , Jiang Hui , Yan Dan , Lin Ya , Ding Yan , Lu Yawen , Zhu Xiaole , Chen Xufeng , Li Xiaolin , Liang Gaolin , Xu Huae 
Published: December 2024

AbstractPaclitaxel (PTX) is a first‐line chemotherapeutic drug for non‐small cell lung cancer (NSCLC) but it can induce indoleamine 2,3‐dioxygenase (IDO) activation, which severely lowers down its immuno‐chemotherapeutic effect. To address this issue, a smart peptide hydrogelator Nap–Phe–Phe–Phe–Lys–Ser–Thr–Gly–Gly–Lys–Ala–Pro–Arg–OH (Nap‐T), which co‐assembles with PTX and an IDO inhibitor GDC0919 to form a hydrogel GP@Gel Nap‐T, is rationally designed. Upon specific phosphorylation by pyruvate kinase M2 (PKM2), an overexpressed biomarker of NSCLC, Nap‐T is gradually converted to Nap–Phe–Phe–Phe–Lys–Ser–Thr(H2PO3)–Gly–Gly–Lys–Ala–Pro–Arg–OH (Nap‐Tp), leading to dehydrogelation and sustained release of PTX and GDC0919 within NSCLC tissues. The released PTX exerts chemotherapy on NSCLC cells as well as immunogenic cell death induction, while GDC0919 promotes the immuno‐chemotherapeutic effect of PTX through IDO inhibition. We find that GP@Gel Nap‐T enhances the infiltration of tumor‐infiltrating immune cells and reduces the number of immunosuppressive cells in either tumor tissues or tumor‐draining lymph nodes, thus enhancing the immuno‐chemotherapy of PTX toward NSCLC. With this PKM2‐responsive drug release strategy, the smart peptide hydrogel platform might be applied for NSCLC treatment in clinic in near future.
Multidimensional Proteomic Landscape Reveals Distinct Activated Pathways Between Human Brain Tumors
Authors: Yang Shuang , Zheng Yongtao , Zhou Chengbin , Yao Jun , Yan Guoquan , Shen Chengpin , Kong Siyuan , Xiong Yueting , Sun Qingfang , Sun Yuhao , Shen Huali , Bian Liuguan , Qian Kun , Liu Xiaohui 
Published: December 2024

AbstractBrain metastases (BrMs) and gliomas are two typical human brain tumors with high incidence of mortalities and distinct clinical challenges, yet the understanding of these two types of tumors remains incomplete. Here, a multidimensional proteomic landscape of BrMs and gliomas to infer tumor‐specific molecular pathophysiology at both tissue and plasma levels is presented. Tissue sample analysis reveals both shared and distinct characteristics of brain tumors, highlighting significant disparities between BrMs and gliomas with differentially activated upstream pathways of the PI3K‐Akt signaling pathway that have been scarcely discussed previously. Novel proteins and phosphosites such as NSUN2, TM9SF3, and PRKCG_S330 are also detected, exhibiting a high correlation with reported clinical traits, which may serve as potential immunohistochemistry (IHC) biomarkers. Moreover, tumor‐specific altered phosphosites and glycosites on FN1 are highlighted as potential therapeutic targets. Further validation of 110 potential noninvasive biomarkers yields three biomarker panels comprising a total of 19 biomarkers (including DES, VWF, and COL1A1) for accurate discrimination of two types of brain tumors and normal controls. In summary, this is a full‐scale dataset of two typical human brain tumors, which serves as a valuable resource for advancing precision medicine in cancer patients through targeted therapy and immunotherapy.
Graphene Quantum Dot Sensitized Heterojunctions Induce Tumor‐Specific Cuproptosis to Boost Sonodynamic and Chemodynamic Enhanced Cancer Immunotherapy
Authors: Yan Lang , Chang Liang , Tian Yijun , Hu Jinyan , Cao Zhi , Guo Xiang , Geng Bijiang 
Published: December 2024

AbstractCuproptosis that utilizes copper ionophore to induce programmed cell death holds promise for enhancing the effectiveness of conventional anticancer therapies and triggering efficient adaptive immune responses. However, the non‐tumor‐specific release of Cu ions can induce cuproptosis and cause irreversible damage to normal tissues. To maximize the therapeutic effects of tumor‐specific cuproptosis, this work reports for the first time the regulation of degradation behaviors of Cu‐based nanomaterials using graphene quantum dots (GQDs) as a protection layer. The deposition of GQDs not only avoids the degradation of Cu2O nanocubes under normal physiological conditions, but also sensitizes their sonodynamic activity due to the formation of Z‐scheme heterojunctions. The tumor‐specific released Cu ions achieve the cascade amplification of reactive oxygen species (ROS) generation through Cu+‐mediated Fenton‐like reaction and Cu2+‐facilitated GSH depletion. More importantly, the immunosuppressive tumor microenvironment (TME) can be reversed by the greatly enhanced ROS levels and high‐efficiency cuproptosis, ultimately inducing immunogenic cell death that promotes robust systemic immune responses for the eradication of primary tumors and suppression of distant tumors. This work provides a novel paradigm for the integration of SDT, CDT, cuproptosis, and immunotherapy in a controlled manner to achieve tumor‐specific antitumor therapy by controlling the degradation behaviors of Cu‐based nanomaterials.
Ultraflexible Sensor Development via 4D Printing: Enhanced Sensitivity to Strain, Temperature, and Magnetic Fields
Authors: Hou Yanbei , Zhang Hancen , Zhou Kun 
Published: December 2024

AbstractThis paper addresses the trade‐off between sensitivity and sensing range in strain sensors, while introducing additional functionalities through an innovative 4D printing approach. The resulting ultraflexible sensor integrates carbon nanotubes/liquid metal hybrids and iron powders within an Ecoflex matrix. The optimization of this composition enables the creation of an uncured resin ideal for Direct Ink Writing (DIW) and a cured sensor with exceptional electromechanical, thermal, and magnetic performance. Notably, the sensor achieves a wide linear strain range of 350% and maintains a stable Gauge Factor of 19.8, offering an ultralow detection limit of 0.1% strain and a rapid 83‐ms response time. Beyond superior strain sensing capabilities, the sensor exhibits outstanding thermal endurance for temperatures exceeding 300 °C, enhanced thermal conductivity, and a consistent resistance‐temperature relationship, making it well‐suited for high‐temperature applications. Moreover, the inclusion of iron particles provides magnetic responsiveness, enabling synergistic applications in location and speed detection, particularly in home care. Leveraging DIW facilitates the creation of complex‐shaped sensors with multiple functional materials, significantly broadening the sensor's capabilities. This convergence of additive manufacturing and multifunctional materials marks a transformative step in advancing the performance of next‐generation sensors across diverse domains.
N‐glycosylation Modification of CTSD Affects Liver Metastases in Colorectal Cancer
Authors: Xiong Nan , Du Yan , Huang Chuncui , Yan Quanyi , Zhao Long , Yang Changjiang , Sun Qing , Gao Zhidong , Wang Caihong , Zhan Jun , Zhang Hongquan , Wang Shan , Ye Yingjiang , Li Yan , Shen Zhanlong 
Published: December 2024

AbstractLiver metastasis is the primary factor contributing to unfavorable prognosis in colorectal cancer (CRC). Although N‐glycosylation is implicated in metastasis, there is a notable paucity of comprehensive studies addressing the N‐glycosylation proteomics associated with liver metastasis in CRC. In this study, N‐glycosylated proteins and N‐glycosylation sites of differential expression between primary lesions and paired liver metastatic lesions are identified. Cathepsin D (CTSD) is further screened as a potentially pivotal N‐glycosylated protein in CRC liver metastasis. Glycosyltransferases complex DDOST and STT3B can regulate N‐glycosylation modification at residue 263 of CTSD (a protease), thereby affecting CTSD protease to lyse ACADM. ACADM can regulate ferroptosis‐related proteins (ACSL4, SLC7A11, and GPX4) to further influence the invasion and metastasis of CRC cells. This newly discovered mechanism provides potential therapeutic targets for CRC treatment and insights for controlling CRC progression and metastasis.
Porous Deep Eutectic Solvents–Unfulfilled Dream or the Next Breakthrough in Scientific Innovation?
Authors: Wysokowski Marcin , Makoś‐Chełstowska Patrycja , Brzęczek‐Szafran Alina , Sikora Aleksandra , Gorczyński Adam , Jesionowski Teofil 
Published: December 2024

AbstractPorous deep eutectic solvents (PDES) are capturing the imagination of scientists, promising a revolutionary leap in material science. These innovative materials, blending the versatility of deep eutectic solvents (DES) with the intricate architectures of porous structures, offer an exciting array of applications—from green chemistry and catalysis to energy storage and environmental remediation. However, the journey from laboratory curiosity to industrial application is fraught with challenges. This perspective article analyzes the realm of PDES, scrutinizing the cutting‐edge advancements and the challenges that lie ahead. By exploring their synthesis, unique properties, and diverse application potential, the critical question is asked: are PDES an unfulfilled dream or the next big breakthrough in scientific innovation? A comprehensive analysis reveals a “landscape” ripe with opportunity, suggesting that with targeted research and development, PDES can indeed become a cornerstone technology, driving progress across multiple scientific domains.
Modulating Acceptor Phase Leads to 19.59% Efficiency Organic Solar Cells
Authors: Bai Liang , Chung Sein , Zhao Zhenmin , Zhao Jingjing , Sun Yuqing , Liu Yuan , Tan Lixing , Zhong Jiancheng , Lyu Sooji , Ji Hojun , Cho Kilwon , Kan Zhipeng 
Published: December 2024

AbstractNonfullerene acceptors are critical in advancing the performance of organic solar cells. However, unfavorable morphology and low photon‐to‐electron conversion in the acceptor range continue to limit the photocurrent generation and overall device performance. Herein, benzoic anhydride, a low‐cost polar molecule with excellent synergistic properties, is introduced in combination with the traditional additive 1‐chloronaphthalene to optimize the aggregation of nonfullerene acceptors. This dual additive approach precisely modulates the morphology of various acceptors, significantly enhancing device performance. Notably, the method induces the formation of fine fibers with dense polymorph structures in BTP‐base derivatives, achieving an optimal balance between exciton dissociation and charge collection in the active layers. As a result, the external quantum efficiency of the optimal devices is markedly improved in the wavelength range of 700–850 nm. Ultimately, power conversion efficiencies of 18.27% and 19.59% are achieved for devices comprising PM6:Y6 and PM6:L8‐BO, respectively. The results reveal a convenient and effective method to control the morphology of nonfullerene acceptors and improve the photovoltaic performance of organic solar cells, paving the way for more efficient and practical organic photovoltaic technologies.