bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Intelligent Manufacturing Mode With Human-cyber-physical Collaboration and Fusion in the Non-Ferrous Metal Industry
Authors: Liu Qing , Liu Min , Wang Zichun , Yan Feng , Ma Yingyi , Shen Weiming 
Published: July 2021

Abstract
The non-ferrous metal industry is one of the most important part in China’s process industry, and has an extremely important strategic position in national economy. However, in the smelting process of non-ferrous metal, there still exists many problems: 1) the production process of non-ferrous is long, the utilization rate of resource and energy is low; 2) the large amount of waste discharge in the production process has caused prominent environmental protection issue; 3) product homogeneity is serious and the added value is low. To solve these problems, we constructed a novel intelligent manufacturing mode with human-cyber-physical (HCP) collaboration and fusion from three aspects: 1) intelligent manufacturing system with HCP collaboration and fusion, 2) product service system based on ecosystem platform, and 3) sustainable business model, to realize the safe, efficient and green production for the non-ferrous metal smelting process. In the case study on the largest copper smelting enterprise in the world, the digital twin based manufacturing system collaborative platform architecture, product &service system framework, and sustainable business model canvas are built by the proposed intelligent manufacturing mode with HCP collaboration and fusion.
Effects of A Nurse-Led Transitional Burns Rehabilitation Programme (4Cs-TBuRP) For Adult Burn Survivors: Protocol for a Randomised Control Trial
Authors: BAYUO JONATHAN , Wong Frances Kam Yuet Yuet , Chung Loretta Yuet Foon 
Published: July 2021

Abstract
Background: Transitioning from the burn unit to the home/ community can be chaotic with limited professional support. Some adult burn survivors may face varied concerns leading to poor outcomes in the early post-discharge period with limited access to professional help. Based on these, a nurse-led transitional burns rehabilitation programme has been developed and the current trial aims to ascertain its effects as well as explore the implementation process. Methods: A single-centre, double-arm randomised controlled trial with a process evaluation phase will be utilised for this study. All adult burn survivors aged ≥18 years with burn size ≥10% total burn surface area at the site during the study period will be screened for eligibility at least 72hours to discharge. A sample size of 150 will be block randomised to treatment (receiving the nurse-led transitional care programme and routine post-discharge service) and control groups (receiving routine post-discharge service). The nurse-led transitional care programme comprises of predischarge and follow-up phases with the delivery of bundle of holistic interventions lasting for 8 weeks. There are three timelines for data collection: baseline, immediate post-intervention, 4 weeks post-intervention. Discussion: The findings from this study can potentially inform the development and organisation of post-discharge care and affirm the need for ongoing comprehensive home-based care for burn survivors and their families. Trial registration: ClinicalTrials.gov Trial Registry approved the prospective registration on 20 th August 2020. Registration details can be viewed on https://clinicaltrials.gov/ct2/show/record/NCT04517721 .
Long Non-Coding RNA NEAT1 Accelerates Lung Cancer Development Via MicroRNA-107/FOXK1 Axis
Authors: Cao Peng , Hu Shan , Kong Kangle , Han Peng , Deng Yu , Li fan , Zhao Bo 
Published: July 2021

Abstract
Objective: Studies have abstracted the partial mechanism of long non-coding RNA nuclear enriched abundant transcript 1 (NEAT1) in lung cancer, but its reciprocal with microRNA-107/Forkhead box k1 (miR-107/FOXK1) is not disclosed clearly. Hence, the mechanism of NEAT1/miR-107/FOXK1 was delved out in lung cancer.Methods: NEAT1, miR-107 and FOXK1 expression in clinical cancer tissues were determined, along with their interactions. The relation between the survival of lung cancer patients and NEAT1 expression was determined. NEAT1 and/or miR-107-related lentivirus or plasmid were transfected into A549 cells, after which cell biological functions were tested. Tumors were xenografted in mice to observe tumor formation and cell apoptosis.Results: High NEAT1 and FOXK1 and low miR-107 levels were tested in lung cancer tissues. High NEAT1 was connected with low overall survival of lung cancer patients. Depleting NEAT1 or augmenting miR-107 inhibited the biological functions of lung cancer cells. Depleted NEAT1 suppressed tumor-forming ability of A549 cells in vivo. Inhibited miR-107 antagonized depleted NEAT1-mediated effects on A549 cells. NEAT1 regulated FOXK1 by competitively binding miR-107.Conclusion: Silenced NEAT1 suppresses lung cancer development through elevating miR-107 and reducing FOXK1 expression, which supplies a plan to treat lung cancer.
Self-Organization of Water Molecules Over 11-Year Solar Cycle
Authors: Shevchenko Igor 
Published: July 2021

Abstract
The variations of solar activity and distribution of solar energy due to the rotation of the Earth around its axis and around the Sun exert a strong influence on the self-organization of water molecules. As a result, the rate of hydrolytic processes with the participation of water clusters displays diurnal, very large annual variations, and is also modulated by the 11-year cycles of solar activity. It also depends on the geographic latitude and can be different at the same time in the Northern and Southern Hemispheres.
This phenomenon is well accounted for by the influence of muons on the self-organization of water molecules. Muons are constantly generated in the upper atmosphere by the solar wind. They reach the surface of the Earth and can penetrate to some depth underground. Buildings also absorb muons. For this reason, the rate of hydrolysis outside and inside buildings, as well as underground, can differ significantly from each other.
Changes in NfL Plasma Levels and Association with Cognitive and Imaging Markers of Alzheimer’s Disease
Authors: Bajaj Sumali , Hadjichrysanthou Christoforos , McRae-McKee Kevin , De Wolf Frank , Anderson Roy M. 
Published: July 2021

Abstract
INTRODUCTION: We assessed the association of plasma neurofilament light chain (pNfL) with cognitive decline and neuroimaging markers, and investigated its potential relationship with the clinical progression to dementia due to Alzheimer’s disease (AD).METHODS: Individuals had evidence of amyloid beta accumulation. Linear and beta-regression models were developed to consider: i) the association between pNfL and cognition, ii) the association between the rate of change (ROC) of pNfL and that of imaging markers, iii) the temporal dynamics of pNfL before and after cognitive impairment as assessed by the Clinical Dementia Rating.RESULTS: Higher levels of pNfL were associated with declining cognition. The ROC of pNfL was associated with the ROC of ventricular, hippocampal and whole brain volumes, but not with PET amyloid. pNfL levels did not reflect the clinical progression of AD.DISCUSSION: pNfL is associated with cognitive decline and brain imaging markers. However, it is not specific to AD clinical diagnosis.
Targeting Autophagy Peptidase ATG4B With A Novel Natural Product Inhibitor Azalomycin F4a For Advanced Gastric Cancer
Authors: Zhong Lin , Yang Bin , zhang Zhenhua , Wang Xiaojuan , Guo Yinfeng , Huang Weifeng , Wang Qianqian , Cai Guodi , Xia Fan , Zhou Shengning , Ma Shuai , Nie Yichu , Lei Jinping , Li Min , Liu Peiqing , Deng Wenbin , Liu Yonghong , Wang Junfeng , Han Fanghai , Wang Junjian 
Published: July 2021

Abstract
Background: Advanced gastric cancer (GCa) remains highly lethal due to the lack of effective therapies. Identifying promising therapeutic targets and developing effective treatment against GCa are urgently needed. Here, we investigated whether Autophagy-related gene 4B (ATG4B) could be a potential therapeutic target against GCa and identified marine natural product Azalomycin F4a (Am-F4a) as a potent ATG4B inhibitor and a potential anticancer agent. Methods: The expression of ATG4B in clinical GCa tumor specimens were examined by immunoblotting and interrogation of public databases. The association between ATG4B expression and patient’s survival was assessed. FRET, surface plasmon resonance, transmission electron microscopy analysis, enzyme activity assay and compute docking were used to assess the binding and inhibition of ATG4B by Am-F4a. RNA interference, inhibitors, CCK-8 cell viability assay, colony formation, apoptosis assay, wound-healing, transwell invasion assay, western blotting and Patient-derived organoids were used to assess the role of ATG4B in GCa cells. GCa cell-derived xenograft models, patient-derived xenografts and orthotopic metastasis xenografts were used to evaluate the anti-tumor growth and anti-metastasis effects of Am-F4a alone or in combination with 5-FU in vivo.Results: ATG4B was highly upregulated in GCa tumors. Its high expression was associated with patient’s poor prognosis. knockdown of ATG4B significantly inhibited GCa cell survival and tumor growth. Am-F4a was identified as a novel and potent ATG4B inhibitor. Am-F4a effectively inhibited GCa cell autophagy and growth via targeting ATG4B both in vitro and in vivo. Besides, both pharmacological inhibition and knockdown of ATG4B significantly suppressed GCa cell migration and invasion. Am-F4a potently blocked the metastasis of primary GCa tumors and effectively sensitized tumors to chemotherapy.Conclusion: These findings indicate that ATG4B is a potential novel therapeutic target against GCa and that the natural product Am-F4a is a novel ATG4B inhibitor that can be further developed for treatment of GCa.
Research on Magnetic Bead Motion Characteristics based on Magnetic Beads Preset Technology
Authors: Li Zhao , Zu Xiangyang , Du Zhe , Hu Zhigang 
Published: July 2021

Abstract
In order to improve the detection efficiency and accuracy of microfluidic chip, a magnetic beads preset technology were designed by using double permanent magnets as external magnetic field and the motion characteristics of preset magnetic beads were studied. The control principle of magnetic beads preset technology was introduced in detail, and the control structure was designed. The coupled field characteristics for magnetic beads in microchannels were analyzed, and the motion models of magnetic beads were established based on the bead preset technology, including capture motion and mixing motion. The relationship between the magnetic field force and the flow velocity for capturing magnetic bead, and the mixing time under the influence of flow field and magnetic field were derived. The magnetic beads capture effect of magnetic beads preset technology was verified by experiments. The study showed the magnetic beads preset technology can better realize the accuracy and efficiency of the magnetic bead control in the microchannel. The derivation of the magnetic bead motion model can understand the motion characteristics of the magnetic bead more clearly, facilitate accurate control of the magnetic bead, and improve the success rate of the microfluidic detection.
Incidence of and Risk Factors for Missing Events Due to Wandering in Community-dwelling Older People with Dementia and Mild Cognitive Impairment
Authors: Jeong seungwon , Suzuki Takao , Miura Kiyoko , Sakurai Takashi 
Published: July 2021

Abstract
BackgroundThe burden of missing incidents is not only on the person with dementia, but also on their family, neighbors, and community. The extent to which dementia-related wandering and missing incidents occur in the community has not been evaluated thoroughly in the published literature. Therefore, we evaluated the incidence of and risk factors for missing events due to wandering.MethodsWe conducted a non-randomized prospective one-year follow-up cohort study based on symptom registration with missing events due to wandering as the endpoint. In the first consultation, 374 patients with dementia or mild cognitive impairment (MCI) and their caregivers who visited the National Center for Geriatrics and Gerontology in Japan were included. The incidence and recurrence rate of missing events were calculated. Participants were divided into (those with) dementia and (those with) MCI. Patients' basic and medical information was documented at baseline and after one year of follow-up. Furthermore, analysis of variance and logistic regression analysis were performed to clarify the risk factors associated with the missing event.ResultsAmong the 236 patients with dementia enrolled, 65 (27·5%) had a previous missing event at baseline, and 28 had a missing event during the one-year follow-up period (recurrence rate of 43·1%). Of the 171 who did not have a previous missing event at baseline, 23 had a missing event during the one-year follow-up period (incidence rate of 13·5%). The scores of Mini-Mental State Examination (MMSE), Dementia Behavior Disturbance Scale (DBD), and Alzheimer's Disease Assessment Scale (ADAS) were statistically significant as the risk factors for the incidence of wandering leading to a missing event (p<0·05).ConclusionsPrevention of missing event due to wandering requires focused attention on changes in the MMSE, DBD, ADAS scores, and the development of a social environment to support family caregivers.
Armington elasticity estimation with or without instruments
Authors: Kim Jiyoung , Nakano Satoshi , Nishimura Kazuhiko 
Published: July 2021

Abstract
This paper discusses measurement of the elasticity of substitution between goods from different countries. To remedy potential endogeneity problems in regression estimations, we use the instrumental variables (IV) approach, and the Feenstra method that does not require the use of instruments. The commodities that we study here and for which we were able to find relevant instruments are bovine, swine, and poultry meat imports by Japan. We find that the two approaches yield very similar results for these commodities. Further, upon extracting the implicit IVs of the Feenstra method, we find them as useful as the external IVs for measuring the aggregate of foreign commodities with a fixed effects regression and for estimating the foreign-domestic substitution elasticity possibly for each commodity.
A Newcastle disease virus-vector expressing a prefusion-stabilized spike protein of SARS-CoV-2 induces protective immune responses against prototype virus and variants of concern in mice and hamsters
Authors: Sun Weina , Liu Yonghong , Amanat Fatima , González-Domínguez Irene , McCroskery Stephen , Slamanig Stefan , Coughlan Lynda , Rosado Victoria , Lemus Nicholas , Jangra Sonia , Rathnasinghe Raveen , Schotsaert Michael , Martinez Jose , Sano Kaori , Mena Ignacio , Innis Bruce , Wirachwong Ponthip , Thai Duong Huu , Oliveira Ricardo , Scharf Rami , Hjorth Richard , Raghunandan Rama , Krammer Florian , Garcia-Sastre Adolfo , Palese Peter 
Published: July 2021

Abstract
Rapid development of coronavirus disease 2019 (COVID-19) vaccines and expedited authorization for use and approval has been proven beneficial to mitigate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread and given hope in this desperate situation. It is believed that sufficient supplies and equitable allocations of vaccines are necessary to limit the global impact of the COVID-19 pandemic and the emergence of additional variants of concern. We have developed a COVID-19 vaccine based on Newcastle disease virus (NDV) that can be manufactured at high yields in embryonated eggs. Here we provide evidence that the NDV vector expressing an optimized spike antigen (NDV-HXP-S), upgraded from our previous construct, is a versatile vaccine that can be used live or inactivated to induce strong antibody responses and to also cross-neutralize variants of concern. The immunity conferred by NDV-HXP-S effectively counteracts SARS-CoV-2 infection in mice and hamsters. It is noteworthy that vaccine lots produced by existing egg-based influenza virus vaccine manufacturers in Vietnam, Thailand and Brazil exhibited excellent immunogenicity and efficacy in hamsters, demonstrating that NDV-HXP-S vaccines can be quickly produced at large-scale to meet global demands.
El desarrollo de la Competencia Digital en el alumnado de Educación Infantil
Authors: Sanchez Vera María del Mar 
Published: July 2021

La Competencia Digital no ha sido incluida, hasta ahora, en el currículo del segundo ciclo de Educación Infantil. No obstante, en los últimos años, diferentes estudios y experiencias educativas han puesto de relieve el potencial que tiene en esta etapa. Este artículo tiene como objetivo conocer y analizar qué aspectos de la Competencia Digital se pueden abordar, así como desarrollar una propuesta de indicadores de logro por edades. Para ello, primero se ha realizado un análisis curricular de la Competencia Digital, a continuación, se ha consultado a 18 maestras expertas en la integración de las tecnologías en el aula de 3 a 6 años.
Los resultados indican que son varios los elementos de la Competencia Digital que pueden integrarse en esta etapa, habiendo encontrado mayor acuerdo en los aspectos relacionados con el conocimiento de aplicaciones informáticas, desarrollo de la curiosidad por las TIC, pensamiento computacional, gestión de la información, usar recursos tecnológicos para resolver problemas y comunicarse. Los aspectos relacionados con la gestión y el uso de información de manera crítica se valoraron como los más complicados de trabajar en esta etapa, siendo elementos que se van incorporando de forma progresiva debido al propio desarrollo madurativo del alumnado.
Migration characteristics of atrazine in porous media during managed aquifer recharge
Authors: Sun Xiuxiu , Wang Weiping , Zhao Weidong , Qu Shisong , Zheng Qingyang 
Published: July 2021

Abstract
To study the influences of sand and gravel layer and groundwater velocity of Yufuhe River on atrazine migration, adsorption-desorption and sand column experiments were carried out. Results show that the adsorption capacity of montmorillonite, raw sand and washed sand to atrazine sequentially weakens. In different media, the time for atrazine concentrations to peak in washed sand with montmorillonite (WSM), raw sand and washed sand is 60, 135 and 105 minutes respectively, and the peak concentration accounts for 84, 90 and 95% of the initial concentrations. Under different flow rates, the peak time in washed sand at flow rates of 100, 150 and 200 mL/min is 135, 105 and 75 minutes, and the peak time in WSM is 90, 60 and 45 minutes, respectively. Results from this study indicate that increasing flow velocity and suspended colloids concentrations can promote the migration of atrazine in aquifers, while the presence of clay minerals in sand and gravel layers can reduce atrazine migration. Thus, during Yellow River water recharging, the sand and gravel layer of Yufuhe River is helpful to protect the aquifer, but the colloids-associated migration of atrazine can contaminate groundwater in underlying karst aquifer.
Effect of organic concentration on biological activity and nitrogen removal performance in an anammox biofilm system
Authors: Fu Weide , Zhu Rencheng , Lin Huanyun , Zheng Yukai , Hu Zhanbo 
Published: July 2021

Abstract
The effects of different concentrations of organic matter on the biological activity and nitrogen removal performance of the anaerobic ammonium oxidation (anammox) system was studied. The results showed that under the conditions of low influent total organic carbon (TOC ≤ 100 mg/L), the activity rate of anammox bacteria was basically unaffected, the anammox bacteria and denitrifying bacteria formed a good synergistic effect, and the maximum total nitrogen (TN) removal efficiency reached 95.77%. However, when the influent TOC concentration was up to 200 mg/L, the activity of anammox bacteria was seriously inhibited. At this time, denitrification becomes the main pathway of nitrogen removal, the effluent ammonia nitrogen content increases, and the TN removal efficiency decreases to 64.17%. High-throughput sequencing analysis showed that with the increase in organic matter concentration, the relative abundance of Proteobacteria and Planctomycetes changed significantly. In particular, the relative abundance proportion of Proteobacteria increased from 21.06% to 25.57%, the Planctomycetes dropped from 10.01% to 3.03% and the Candidatus Brocadia genus had the largest decrease. In conclusion, the concentration range of organic matter for collaborative denitrification was proposed in this study, which provided theoretical reference for the practical application of anammox biofilm process.
Distribution characteristics and source analysis of sulfate in the main rivers of Heze city, China
Authors: Ma Qiang , Xing Chuanjie , Sun Huizhong , Zhang Xue , Xu Lirong 
Published: July 2021

Abstract
Throughout the last few decades, sulfate concentrations in streamwater have received considerable attention due to their dominant role in anthropogenic acidification of surface waters. In order to determine the cycle of riverine sulfate, affected by natural weathering and anthropogenic activities, the Zhuzhaoxin River Basin and Dongyu River Basin in Heze City, China are selected. The conventional hydrochemical characteristics, distribution characteristics of sulfate concentration, and distribution characteristics of sulfur and oxygen isotopes are analyzed and texted. The results are as follows: the concentration of SO42− in the surface water of the study area increased gradually from upstream to downstream. In the study area, the δ34SSO4 and δ18OSO4 value in the surface water of Zhuzhaoxin River Basin ranges from +8.0‰ to +22.3‰ and +7.3‰ to +10.5‰, respectively, while the values of Dongyu River Basin are between +9.3‰ ∼ +9.5‰ and +4.2‰ ∼ +8.1‰. The main sources of SO42− in the Zhuzhaoxin River Basin are domestic sewage, industrial and mining wastewater and the evaporation of dissolved salt rock, and their average contribution rates are more than 50% and 30%, respectively; the main sources of SO42− in the Dongyu River Basin are agricultural activities and atmospheric precipitation, and their average contribution rates are more than 60% and 20%, respectively.