bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-Utility Analysis of Percutaneous and Surgery Methods in Extraction of Cardiac Leads Infection
Authors: shaker zinab , Barooni Mohsen , Mahani Asma Saber , Shaker Zohreh 
Published: August 2021

Abstract
Introduction: Cardiovascular diseases are currently major concern in the world and It is expected that Until 2030, 7 out of 10 deaths in world will be related to cardiovascular diseases. Despite the increase in Pasemaker and ICD implants in recent years, the complications of this devices are increasing. One of the most important complications is the pulsating lead infection. The purpose of this study was to analyze the cost-effectiveness of percutaneous and surgical method in extracting pacemaker leads with Qaly index.Methods: In this cross-sectional article (descriptive-analytical) using the Markov model, for compare the two methods of percutaneous and surgery for infectious lead. Sampling was census and ( sample size for percutaneous included 57 people) and information about utility was extracted by the SAQ questionnaire. A systematic review was performed to calculate utility of the surgical Cost from the perspective of the service provider. data analysis by SPSS software, and TreeAge software was used for Markov modeland and sensitivity analysis .Results: Changes in quality of life score in both intervention were incremental and significant and intervention is the only effective factor in changes in quality of life score (P <0.05). The ICER was 5470.44$.Conclusion: The results of the study show that utility and cost of surgery are higher than the percutaneous method.Sensitivity analysis shows If the cost of surgery increases more than 806.52$ (discount rate of 0.06), the percutaneous method dominates the surgery method.
Treatment of Osteoporotic Vertebral Compression Fracture by Precise Injection and Staged Perfusion of Bone Cement Kyphoplasty: A Comparison Study
Authors: Huang Jian , Huang Jun , Chen Ming , Zhou Zongbo , Lu Zhifu , Fu Chuangong 
Published: August 2021

Abstract
Study design: Retrospective cohort study.Objective: To explore the clinical effect of precise injection and staged perfusion of bone cement kyphoplasty in the treatment of osteoporotic vertebral compression fracture.Methods: 110 patients treated with kyphoplasty from January 2020 to June 2021 were selected and divided into experimental group (n = 55) and control group (n = 55) according to different surgical methods. The experimental group was treated with precise injection and staged perfusion of bone cement kyphoplasty, while the control group was treated with traditional kyphoplasty. The operation time,intraoperative blood loss and amount of bone cement injection were recorded. The pain improvement was evaluated by VAS score. The operation effect were evaluated by anterior height of injured vertebral body, middle height of injured vertebral body, wedge angle of injured vertebral body and distribution grade of bone cement. The incidence of surgical complications was evaluated by the number of bone cement leakage.Results: There were no significant difference in the operation time, intraoperative blood loss and the amount of bone cement injection in two groups. There were no significant difference in VAS scores at 2h, 4h and 48h after operation between the two groups (P > 0.05); There were no significant difference in the ratio of anterior height of injured vertebral body between the two groups on the third day after operation and the last follow-up (P > 0.05); There were no significant difference in the ratio of middle height of injured vertebral body between the two groups on the third day after operation and the last follow-up (P > 0.05); There were no significant difference in wedge angle of injured vertebral body between the two groups at the third day after operation and the last follow-up (P > 0.05). There was significant difference in the distribution grade of bone cement between the two groups (P < 0.01); There was significant difference in the number of bone cement leakage between the two groups (P < 0.01), In cases of bone cement leakage, there were 1 case of type C, 1 case of type S in the experimental group, 7 cases of type C and 2 cases of type S in the control group.Conclusion: Precise injection and staged perfusion of bone cement kyphoplasty in the treatment of osteoporotic vertebral compression fracture can effectively reduce surgical complications and improve surgical efficacy.
A Persian Brain-Computer Interface Speller Based on P300 and Language Model Utilization
Authors: Veisi Hadi , Amini Hessam , Daeijavad Parisa 
Published: August 2021

Abstract
Background: Brain-computer interface (BCI) is a system in which complete control is exerted directly through brain signals. One of the most important applications of BCI is in spellers, which are designed to restore communication ability for people with severe speech and motor impairments. These people can communicate using a BCI speller by spelling their desired words. The goal of this paper is to present the achievements of a project whose ultimate purpose is to propose a Persian BCI speller, which utilizes a Persian language model as an assisting tool to improve its performance.Method: In this study, we first present our method for data collection. To collect the dataset, we designed a screen that is used to display the visual stimuli. Furthermore, we carefully selected the words used in the data collection process. Using the designed stimuli screen and the selected words, the dataset from 5 subjects is collected. This dataset is used in different signal processing and machine learning methods in the designed speller. To classify the P300 signal for spelling purposes, first, the feature vectors of data samples were extracted by the concatenation of the electroencephalography (EEG) channels, which were filtered using a moving average filter. Then, using a support vector machine (SVM), the samples were classified and the results were fused with character-level N-grams to detect the target characters.Results: In the evaluation of the system, we have achieved an average accuracy of 93.2% in character detection by utilizing a character-level 5-gram language model.Conclusions: The assessment of the language models in the system demonstrated that using the 5- gram language model resulted in increasing the accuracy by 1.9% compared to when no language models were used.
Assessment of Nutritional And Free Radical Scavenging Activity of Selected Genotypes of Cordia Myxa L.: A Potential Underutilized Fruit Crop of Indian Arid Zone
Authors: Meghwal Purkha Ram , Singh Dalpat , Swami Saurabh , Singh Akath 
Published: August 2021

Abstract
Cordia myxa is one of the important underutilized fruit plants suitable for arid and semi-arid regions of India having potential for commercial exploitation in vegetable and pickle industry. Fruits of four improved genotypes of Cordia myxa were analyzed for nutritional value, total phenol content and free radical scavenging activity. Acetone extracts from dried fruit samples were prepared to determine total phenol content and free radical scavenging activity using DPPH essay. The fruits harvested at 20 or 30 days after fruit set recorded higher crude fibre and crude protein as compared to at full ripening stage. The total phenol content was found highest in fruits harvested earliest irrespective of genotypes. The correlation coefficient between total phenol content and free radical scavenging activity of fruit extract was found positive and significant. The results suggest that the fruits of Cordia myxa should be harvested at 20 to 30 days after fruit set to get maximum benefits of its anti-oxidant and other nutritional properties.
Postoperative Pulmonary Infection in Elderly Patients With Hip Fracture: More Attention Needed
Authors: Yu Yibing , Zheng Peiwen 
Published: August 2021

Abstract
Background: Postoperative pulmonary infection is a serious complication in elderly patients with hip fracture, it’s necessary to identify the influencing factors of pulmonary infection in patients with hip fracture.Methods: Elderly patients with hip fractures admitted from January 1, 2020 to July 31, 2021 were included. The characteristics of patients with pulmonary infection and no infection were evaluated and compared. Logistic multivariate regression analyses were conducted to assess the risk factors of pulmonary infection.Results: 267 patients with hip fracture were included, the incidence of pulmonary infection in patients with hip fracture was 13.11%. There were significant differences in the age, diabetes mellitus, anemia, hypoalbuminemia, anesthesia method and duration of surgery between infection and no infection group, no significant differences in the gender, BMI, hypertension, hyperlipidemia, type of fracture, preoperative oxygen saturation, white blood cell count, platelet count, red blood cell count, creatinine, alanine aminotransferase, aspartate aminotransferase, estimated blood loss during surgery were detected between infection and no infection group. Logistic regression analysis showed that age≥70y(OR2.326 , 95%CI1.248~3.129), diabetes mellitus(OR2.123, 95%CI1.021~3.551), anemia(OR3.199,95%CI1.943~5.024), hypoalbuminemia(OR2.377, 95%CI1.211~3.398), general anesthesia(OR1.947, 95%CI1.115~3.038), duration of surgery≥120min(OR1.621 , 95%CI1.488~2.534) were the risk factors of pulmonary infection in elderly patients with hip fracture(all p<0.05). Escherichia Coli(33.33%), Klebsiella pneumoniae(28.57%), Staphylococcus aureus(21.43%) were the most common bacteria of pulmonary infection.Conclusion: There are many risk factors for pulmonary infection in elderly patients with hip fractures after surgery. In clinical practice, medical workers should take targeted interventions for those risk factors to reduce the risk of pulmonary infection.
A Novel Risk Predictive Scoring Model For Predicting Subsequent Infection After Carbapenem-Resistant Gram-Negative Bacteria Colonization In Hematological Malignancies Patients
Authors: Wu Qiuling , Qian Chenjing , Ying Hua , Liu Fang , Wu Yaohui , Li Weimig , Xia Linghui , Ma Ling , Hong Mei 
Published: August 2021

Abstract
PurposeTo investigate the high-risk factors associated with the increased vulnerability for subsequent clinical infection in Carbapenem-resistant Gram-negative bacteria (CR-GNB) colonized hematological malignancies (HMs) patients, and build a statistical model to predict subsequent infection.MethodAll adult HMs patients with positive anal swab culture for CR-GNB between January 2018 and June 2020 were prospectively followed to assess for any subsequent CR-GNB infections and to investigate the risk factors and clinical features of subsequent infection.ResultsA total of 392 HMs patients were enrolled. Of them, 46.7% developed a subsequent clinical infection, and 42 (10.7%) were confirmed infection and 141 (36%) were clinically diagnosed infection. Klebsiella pneumoniae was the dominant species. The overall mortality rate of patients colonized and infected with CR-GNB was 8.6% and 43.7%. A multivariate analysis showed that remission induction chemotherapy, the duration of agranulocytosis, mucositis, and hypoalbuminemia were significant predictors of subsequent infection after CR-GNB colonization. According to our novel risk predictive scoring model, the high-risk group were > 3 times more likely to develop a subsequent infection in comparison with the low-risk group.ConclusionOur risk predictive scoring model can early and accurately predict subsequent infection in HMs patients with CR-GNB colonization. Early administration of CR-GNB-targeted empirical therapy in the high-risk group is strongly recommended to decrease their mortality.
Significance of Rock Mineral Composition On Rock Mechanical Properties And Brittleness Evaluation of Roof And Floor of Broken Soft Coal Seam
Authors: Hu Guangqing , Liang Wenxu , Shan Qingting , Zhao Meng , Shi Xianzeng , Wu Dun 
Published: August 2021

Abstract
Fracture of coal structure and low permeability were the main reasons for the “difficult to released gas” in broken soft coal seam. Exploration of horizontal well coalbed gas technology of roof and floor of broken soft coal seam provided a new technical way for coalbed gas development in broken soft coal seam. In this paper, taking Xinxie -1 drilling as an example, the evaluation method of fractured reservoirs in roof and floor of broken soft coal seam was improved. By systematic studied on mineralogy, petrology and engineering mechanics characteristics of top and bottom plates in broken soft coal seam, the influence of rock mineral composition on the rock mechanics properties of the roof and floor of coal seam was explored. In addition, By used correlation analysis and grey relational analysis, a brittle evaluation method of coal seam top and bottom plates based on mineral composition was established. The research results showed that: ①The main components of rock minerals in the top and bottom plates of broken soft coal seam were quartz and clay minerals, followed by plagioclase, siderite and pyrite. The main types of rock cementation were quartz enlargement and siderite cementation, and the pore damage caused by cementation was much greater than that of compaction; ②With the increased of rock particle size, compressive strength (CS) and elastic modulus (E) showed a gradual increase trend, Poisson's ratio (μ) showed a gradual decrease trend, other rock mechanical parameters had no obvious changes. The difference of mineral composition and cementation type was the key factor cause abnormal mechanical properties of rocks; ③Compared with clay minerals, the change of brittle mineral content such as quartz, plagioclase and siderite in rocks were sensitive to the mechanical properties of rocks. The sensitive minerals of compressive strength, shear strength, elastic modulus and softening coefficient were quartz, the sensitive minerals of compressive strength were plagioclase and siderite, and the sensitive minerals of Poisson's ratio are quartz and clay; ④The calculation results of the established mineral weight analysis method were more realistic. It could be concluded that the roof of 13-1 coal, 11-2 coal, 9-2 coal and 4-2 coal seams were more inclined to form fracture network during fracturing, which had guiding significance for the optimization of fracturing horizon.
Polarity Protein Par3 Sensitizes Breast Cancer to Paclitaxel by Promoting Cell Cycle Arrest.
Authors: Chen She , Zhao Yannan , Peng Huitong , Liang Limiao , Li Yi , Hu Xichun , Wang Biyun , Xu Yingying 
Published: August 2021

Abstract
Purpose Paclitaxel, belongs to tubulin-binding agents (TBAs), showed a great efficacy against breast cancer via stabilizing microtubules. Drug resistance limits its clinical application. Here we aimed to explore a role of Polarity protein Par3 in improving paclitaxel effectiveness.Methods Breast cancer specimens from 45 patients were collected to study the relationship between Par3 expression and paclitaxel efficacy. The Kaplan–Meier method was used for survival analysis. Cell viability was measured in breast cancer cells (SK-BR-3 and T-47D) with Par3 over-expression or knockdown. The flow cytometry assays were performed to measure cell apoptosis and cell cycle. BrdU incorporation assay and Hoechst 33258 staining were performed to measure cell proliferation and cell apoptosis, respectively. Immunofluorescence was used to detect microtubule structures. Results Par3 expression is associated with good response of paclitaxel in breast cancer patients. Consistently, Par3 overexpression significantly sensitizes breast cancer cells to paclitaxel by promoting cell apoptosis and reducing cell proliferation. In Par3 overexpressing cells upon paclitaxel treatment, we observed intensified cell cycle arrests at metaphase. Further exploration showed that Par3 overexpression stabilizes microtubules of breast cancer cells in response to paclitaxel, and resists to microtubules instability induced by nocodazole, a microtubule-depolymerizing agent. Conclusion Par3 facilitates polymeric forms of tubulin and stabilizes microtubule structure, which aggravates paclitaxel-induced delay at the metaphase-anaphase transition, leading to proliferation inhibition and apoptosis of breast cancer cells. Par3 has a potential role in sensitizing breast cancer cells to paclitaxel, which may provide a more precise assessment of individual treatment and novel therapeutic targets.
Retrospective Cohort Study of Neonatal Blood Transfusion in China
Authors: Ma Ting , Sun Yang , Wang Qiushi , Liu Fenghua , Hua Kai , Wang Liqin , Song Aowei , Wang Wenhua , Xie Xinxin , Li Xiling , Yang Jiangcun 
Published: August 2021

Abstract
Background: Blood transfusion treatment is extremely important for newborns，but the threshold of neonatal blood transfusion is not same in different countries, which may be due to differences in regions, races and nationalities, as well as medical conditions and treatment methods. Up to now, there are not enough clinical studies and prospective follow-up to determine the suitable threshold for Chinese newborns. Therefore, it is important to establish a retrospective and prospective multicenter cohort study to evaluate whether the blood transfusion scheme is suitable for newborns in China.Methods: This is a retrospective cohort study of neonatal blood transfusion and prospective follow-up from January 1, 2017 to June 30, 2021, aim to evaluate the effect of restricted and unrestricted blood transfusion on neonatal health. Diagnosis and blood transfusion data of 5,669 newborns between January 1, 2017 and June 30, 2018 from 46 hospitals in China were analyzed through retrospective study and followed up for 1w,1m and 3y after discharge. The variable data of newborns and their mothers was collected in this cohort study with 280 variables and 2.98 million data volumes including in the database. The primary outcome index of the study was death, and the secondary outcome index was complications during hospitalization, hospitalization time, NICU hospitalization days and hospitalization expenses.Discussion: The groups were grouped by birth weight, and each group was defined as a restricted and unrestricted cohort according to the Recommended Program for Neonatal Blood Transfusion (5th Edition), and evaluate applicability of this scheme for Chinese newborns based on outcome indicators. According to the neonatal treatment data, a appropriate neonatal blood transfusion threshold and neonatal blood transfusion program for China would be determined.
Influence of Size Effect on Dynamic Mechanical Properties of OFHC Copper at Micro/Mesoscopic Scale
Authors: Jing Chuanzhi , Wang Jilai , Zhang Chengpeng , Sun Yan , Shi Zhenyu 
Published: August 2021

Abstract
The dynamic mechanical properties of metallic materials have been extensively investigated at the macro-scale in terms of deformation mechanisms, strain rate strengthening, and fracture mechanisms. However, the dynamic mechanical properties affected by size effects at micro/meso-scales have rarely been investigated. To explore the size effects on the dynamic mechanical properties at micro/meso-scales, the experiments of quasi-static compression and SHPB were carried out using oxygen-free, high-conductivity (OFHC) copper with different geometrical and grain sizes. The experimental results show that the quasi-static and dynamic mechanical properties of OFHC copper are affected by size effects at micro/meso-scales. In particular, OFHC copper exhibits strain rate strengthening effects at the micro/meso-scales, and the presence of micro-cracks was observed in the SHPB experimental specimens. The J-C constitutive model based on the surface layer model is proposed and the analysis of the average relative error of the modified model and the original constitutive model is performed. Finite element analysis was carried out based on the modified J-C model and the original model, and the results show that the modified J-C model was in good agreement with the experimental results.
Characterization of the microRNA Transcriptomes and Proteomics of Cochlea Tissue-derived Small Extracellular Vesicles From Different Age of Mice After Birth
Authors: Jiang Pei , Ma Xiangyu , Han Shanying , Ma Leyao , Ai Jingru , Wu Leilei , Zhang Yuan , Xiao Hairong , Tian Mengyao , Tao W. Andy , Zhang Shasha , Chai Renjie 
Published: August 2021

Abstract
The cochlea is an important sensory organ for both balance and sound perception, and the formation of the cochlea is a complex developmental process. The development of the mouse cochlea begins on embryonic day (E)9 and continues until postnatal day (P)21 when the hearing system is considered mature. Small extracellular vesicles (sEVs), with a diameter ranging from 30 nm to 200 nm, have been considered as a significant medium for information communication in both the processing of physiological and pathological. However, there are no studies exploring the role of sEVs in the development of the cochlea. Here, we isolated tissue-derived sEVs from the cochleae of FVB mice at P3, P7, P14, and P21 by ultracentrifugation. These sEVs were first characterized by transmission electron microscopy, nanoparticle tracking analysis, and western blotting. Next, we used small RNA-seq and mass spectrometry to characterize the microRNA transcriptomes and proteomics of cochlear sEVs from mice at different ages. Many microRNAs and proteins were discovered to be related with inner ear development, anatomical structure development, and the auditory nervous system development. These results all suggest that sEVs exist in the cochlea and are likely to be essential for the normal development of the auditory system. Our findings provide many sEV microRNA and protein targets for future studies of the roles of cochlear sEVs.
HOXA11-AS Regulates NIPAL3 via Hsa-miRNA-19a-3p, Hsa-miR-141-3p and Hsa-miR-140-5p in Keloid Fibroblast: Bioinformatic Analysis and In Vitro Validation
Authors: Wang Qiang , Wang Wei , Sun Xiaojie 
Published: August 2021

Abstract
Background: The long noncoding RNA HOXA11-AS is significantly increased in keloids with an unknown mechanism.Methods: Keloid-derived fibroblasts were primarily cultured from keloid explants (Sample 0). Small inference RNAs (siRNAs) against HOXA11-AS were transinfected in two keloid fibroblasts (Sample 1 and Sample 2). Nonspecific siRNA was transinfected into one keloid fibroblast (Sample 3). The blank plasmid was transinfected into one keloid fibroblast (Sample 4). Five keloid fibroblast samples were sequenced for lncRNAs, mRNAs and miRNAs. Differentially expressed (DE) mRNAs or lncRNAs were obtained in HOXA11-AS-knockdown keloid fibroblasts via DE RNAs from sample 1 intersected from sample 2, removing overlapping nonspecific interfered DE RNAs from sample 3 combined with sample 4. Using stepwise bioinformatics, dominantly functioning mRNAs downstream of HOXA11-AS were scored based on a first-step lncRNA-mRNA-protein (LMP) network in keloid fibroblasts, removing overlapping mRNAs from the nonspecific group. Screened genes were further validated by real-time PCR and western blotting. Validated mRNAs were overtaken to predict a sequence-matched competing endogenous ceRNA network involving the HOXA11-AS (down)- miRNA (up)- validated mRNA (down) pathway in keloid fibroblasts.Results: Six DE profiles (lncRNA, mRNA, miRNA) were obtained in the HOXA11-AS-knockdown group or in the nonspecific interference group. Fourteen dominantly functional genes were enriched in three biological pathways. SNED1, NIPAL3 and VTN were validated in keloid fibroblasts by knocking down HOXA11-AS via real-time PCR. Only NIPAL3 was predicted as a competing endogenous gene downstream of the HOXA11-AS pathway via three sponging miRNAs (hsa-miRNA-19a-3p, hsa-miR-141-3p, hsa-miR-140-5p).Conclusions: HOXA11-AS regulated NIPAL3 via three miRNAs in keloid fibroblasts.