bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monitoring the human right to water in California: development and implementation of a framework and data tool
Authors: Balazs C. , Goddard J. J. , Chang C. , Zeise L. , Faust J. 
Published: September 2021

AbstractEnsuring the human right to water requires monitoring at national or subnational levels, but few comprehensive frameworks exist for industrialized contexts. This paper introduces a subnational-level framework – known as the California Human Right to Water Framework and Data Tool (CalHRTW) – developed by the authors at the California EPA's Office of Environmental Health Hazard Assessment. This paper has two objectives: (1) to present the theoretical foundations and methodology used to develop the first version of CalHRTW (CalHRTW 1.0) and (2) to showcase how results can be used. CalHRTW 1.0 measures three components of the human right to water: drinking water quality, accessibility and affordability for community water systems in California. Nine individual indicators grouped by component, and three indices that summarize component-level outcomes are used to quantify system-level results. CalHRTW allows users to: (1) summarize system-level conditions statewide and identify challenges, (2) explore social equity implications and (3) centralize information for planning. CalHRTW draws on approaches from existing international monitoring efforts and complements existing California efforts by being the first US effort to comprehensively and explicitly monitor the HRTW under one umbrella. This work offers other US states and countries a model to build monitoring efforts to realize the human right to water.
Removal of microplastics from wastewater through electrocoagulation-electroflotation and membrane filtration processes
Authors: Akarsu Ceyhun , Kumbur Halil , Kideys Ahmet Erkan 
Published: September 2021

Abstract
Wastewater treatment plants (WWTPs) are one of the major vectors of microplastics (MPs) pollution for the recipient water bodies. Therefore, the recovery of MPs from WWTPs is extremely important for decreasing their accumulation and impact in aquatic systems. In this present study, the electrocoagulation-electroflotation (EC/EF) and membrane filtration processes were investigated in removing MPs from wastewaters. The effectiveness of different electrode combinations (Fe-Al and Al-Fe), current density (10–20 A/m2), pH (4.0–10.0) and operating times (0–120 min) on the removal of two different polymer particles in water were investigated to obtain maximum treatment efficiency. The effect of pressure (1–3 bar) on membrane filtration removal efficiency was also investigated. The maximum removal efficiencies were obtained as 100% for both polymer types with electrode combination of Al-Fe, initial pH of 7, current density of 20 A/m2 and reaction time of 10 min. The membrane filtration method also displayed a 100% removal efficiency. In addition, these laboratory-scale results were compared with the one-year average data of a plant treating with real-scale membranes. The results indicated that the proposed processes supplied maximum removal efficiency (100%) compared to conventional secondary and tertiary treatment methods (2–81.6%) in the removal of microplastics.
Hydrogeological context and hydrogeoarchaeological heritage associated with the La Mota Fortress (Alcalá la Real, province of Jaén, southern Spain)
Authors: Mudarra Martínez Matías , González Ramón Antonio , Roldán-García Francisco , Peinado Parra Tomás , Calvo Aguilar Carlos , Hidalgo Cano José Luis , Martos Rosillo Sergio 
Published: September 2021

La Mota Fortress is a medieval military enclosure erected on the upper part of the homonymous hill, in Alcalá la Real (province of Jaén, southern Spain). Although previous vestiges have been found, the fortress reached its greatest splendour during the Nasrid-dynasty period (13th and 14th centuries). Its geographical location, in the limit between the old Christian and Muslim kingdoms, conferred a great strategic value to this military complex as a defensive bastion in the northern border of the ancient Kingdom of Granada. This fact caused the citadel to repeatedly be besieged and its inhabitants put into practice a particular system for water supply, based on the combined use of groundwater, stored in the calcareous sandstones of Tortonian age, and rainwater, collected in numerous cisterns sited within city walls. In this paper, the potential interest of this particular supply system is analyzed and discussed. To this end, we describe the hydrogeological functioning of the small aquifer on which the Nasrid fortress was built, and the system of underground wells and galleries that was hidden inside. In addition, the water resources and possible groundwater reserves are evaluated and their physico-chemical characteristics are detailed. Finally, the relevance in the water supply system of one of the most significant withdrawal facilities (Pozo de la Conquista) is analyzed, as well as the role played by the well in the conquest of the city by the Christian troops of Alfonso XI.
Climatic periodicities and astrochronological dating of the Enciso Group in the eastern Cameros Basin (N of Spain)
Authors: Muñoz Arsenio , Angulo Ana , Liesa Carlos L. , Luzón Mª Aránzazu , Mayayo Mª José , Pérez Antonio , Soria Ana R. , Val Víctor , Yuste Alfonso 
Published: September 2021

This study presents the cyclostratigraphic analysis of a detailed, 1,371 m-thick stratigraphic section logged in the Lower Cretaceous syn-rift lacustrine and alluvial deposits of the Enciso Group, in the eastern Cameros Basin. The spectral analysis of a time series based on lithology reveals periodic sedimentary cycles attributable to variations in the eccentricity of the Earth’s orbit around the Sun (131.8 and 39.9 m-thick sedimentary cycles for the long and short orbital eccentricity cycle) and to changes in the obliquity (12.6 m-thick cycle) and the two precession modes (7.7-5.5 m-thick cycles) of the Earth’s rotation axis. We have constructed a floating astrochronological time scale based on the spectral analysis allowing us to propose that the time interval registered in the studied series is ca. 5.4-5.7 Ma, and to estimate an average sedimentation rate of ~255-239 m/Ma. The presence of cycles representing a similar time span but having different thickness, reveals a higher influence of tectonic activity in the central and upper parts of the succession, and discriminate tectonic from climatic signal, the latter being significant throughout the succession. The sedimentary facies and paleontological content of the studied profile, deposited very close to the coastline, have allowed us to interpret a deepening-shallowing cycle that it is proposed to be eustasy-related (transgressive-regressive cycle). The anchoring of this cycle with the sea level curve in combination with the scarce paleontological dates permit the Enciso Group to be located in the Hauterivian-Barremian, that was approximately deposited between 132.5-126.8 or 132.3-126.9 Ma, depending on whether the short or long eccentricity cycle is considered, respectively.
Implications of DFN Model Selection in Open Pit Bench Stability Analyses
Authors: Grenon Martin , Hadjigeorgiou John 
Published: September 2021

A coupled Discrete Fracture Network (DFN) – Limit Equilibrium Analysis (LEA) approach to the design of bench face slopes in open pit mines has significant advantages over conventional analyses. The reliability of this approach is directly related to the quality of the input data and the ability for the generated DFN to adequately capture the characteristics of the rock mass. Different DFN model generators have specific input requirements and inherent assumptions. This paper addresses the critical issue of selecting an appropriate DFN model. Through a worked example, it illustrates the implications of selecting a series of different DFN models and generators on the stability analyses, and interpretation of the results. This is shown to have significant impact on the design of open pit slopes.
siRNA as a Potential Therapy for COVID-19
Authors: Aljaberi Ahmad , Migdadi Eman M. , Khadra Khalid M. Abu , Samak Mahmoud Abu , Basheti Iman A. , Al-Zoubi Nizar 
Published: September 2021

:
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) is a highly contagious
virus causing COVID-19 disease that severely impacted the world health, education, and
economy systems in 2020. The numbers of infection cases and reported deaths are still increasing
with no specific treatment identified yet to halt this pandemic. Currently, several proposed treatments
are under preclinical and clinical investigations now, alongside the race to vaccinate as
many individuals as possible. The genome of SARS-CoV2 shares a similar gene organization as
other viruses in the Coronaviridae family. It is a positive-sense, single-stranded RNA. This feature
suggests that RNA interference (RNAi) is an attractive prophylactic and therapeutic option for the
control of this pandemic and other possible future pandemics of the corona viruses. RNAi utilizes
the use of siRNA molecules, which are 21-29 nt duplexes RNA molecules that intervene with targeted
gene expression in the cytoplasm by a specific mechanism of complementary destruction of
mRNA. Previous experience with SARS-CoV and the Middle East respiratory syndrome (MERS)
showed that siRNA molecules were effective against these viruses in vitro and in vivo. Moreover,
there have been extensive advances in siRNA technology in the past decade from chemistry and target
selection considerations; which concluded with the successful approval of two commercial
products based on siRNA technology. In addition, the current knowledge of the genome structure
and functionality of the corona viruses enables the recognition of conserved sequences to optimize
siRNA targeting and avoid viral escape through mutations, either for the current SARS-CoV2 as
well as future corona viruses.
Assessment of Amentoflavone Loaded Sub-Micron Particle Preparation using
Supercritical Antisolvent for its Antitumor Activity
Authors: Ge Fahuan , Duan Shulei , Jia Jing fu , Hong Biao , Zhou Jie , Zhang Yi , Li Ming 
Published: September 2021

Introduction:
The amentoflavone (AMF) loaded polymeric sub-micron particles were
prepared using supercritical antisolvent (SAS) technology with the aim of improving the anticancer
activity of AMF.

Methods:
Zein and phospholipid mixtures composed of Hydrogenated Phosphatidylcholine (HPC)
and egg lecithin (EPC) were used as carrier materials and, the effects of carrier composition on the
product morphology and drug release behavior were investigated. When the mass ratio of Zein/HPC/
EPC was 7/2/1, the AMF loaded particles were spherical shape and sub-micron sized around
400 nm, with a drug load of 4.3±0.3 w% and entrapment efficacy of 87.8±1.8%. The in vitro drug
release assay showed that adding EPC in the wall materials could improve the dispersion stability
of the released AMF in an aqueous medium, and the introduction of HPC could accelerate the drug
release speed.

Results:
MTT assay demonstrated that AMF-loaded micron particles have an improved inhibitory
effect on A375 cells, whose IC50 was 37.39μg/ml, compared with that of free AMF(130.2μg/ml).

Conclusion:
It proved that the AMF loaded sub-micron particles prepared by SAS were a prospective
strategy to improve the antitumor activity of AMF, and possibly promote the clinical use of
AMF preparations.
SARS-CoV-2 Transmission Among Healthcare Workers in Iran: An Urgent Need for Early Identification and Management
Authors: Abdolsalehi Mohammad Reza , Mahmoudi Shima , Badv Reza Shervin , Pourakbari Babak , Mirnia Kayvan , Mahmoudieh Yasmine , Mamishi Setareh 
Published: September 2021

Introduction:With the increasing rate of COVID-19, particularly in developing countries such as Iran, a high number of frontline service providers, including doctors and nurses, have died, making frontline healthcare workers (HCWs) more vulnerable to psychological disorders and fear and anxiety of secondary transmission to others, especially their family members. In this study, we aimed to report the incidence of COVID-19 infection among HCWs in an Iranian referral pediatrics hospital between April 2020 and July 2020.Material and Methods:In this retrospective cross-sectional study, HCWs and hospital staff working at Children's Medical Center, Tehran, Iran, with positive SARS-CoV-2 real-time polymerase chain reaction (RT-PCR) test results were evaluated between April 2020 and July 2020.Results:Sixty-one out of the 1085 personnel (5.6%) including 14 pediatricians (23%), 24 nurses (39%), 9 paramedics (15%), and 14 HCWs without direct patient contact (23%) had a nasopharyngeal specimen positive SARS-CoV-2 RT-PCR test. The mean age was 39.8±10.6 years. Eleven cases (18%) had underlying diseases such as hypertension and asthma. The most common symptoms were fatigue (67%, n=41), dry cough (61%, n=37), fever (52%, n=32), headache (46%, n=28), dyspnea (43%, n=24), anosmia (28%, n=17), chills (26%, n=16), sore throat (26%, n=16), gastrointestinal symptoms (23%, n=14), and productive cough (3%, n=2). Eleven cases (18%) showed lung involvement in their chest X-rays and/or CT scans. Eighteen cases (29.5%) had lymphopenia, and 20 individuals (33%) had a high level of C-reactive protein.Conclusion:In conclusion, in the early phase of the COVID-19 outbreak, a substantial proportion of HCWs with fever, respiratory, and other prevalent symptoms including fatigue and headache were infected with SARS-CoV-2. Therefore, implementation of infection prevention measures, isolation of confirmed HCWs, disinfection of the environment, and regular COVID-19 prevention training for HCWs are strongly recommended for the wellbeing of health workers and minimizing the spread of infection.
Recent Patents on Ball Bearing
Authors: Pan Cheng-Yi , Tang Jun-Hong , Hu Bing-Tao 
Published: September 2021

Background:
Ball bearings are widely used in industry. They are core components of
mechanical equipment. The research on the structural improvement of ball bearings is beneficial to
enhancing the performance of bearing. Comparing with traditional structure, novel ball bearing has
brought a lot of advantages and solved many problems in the working.

Objective:
The study aims to report the latest research on the structure of ball bearings and provides
a reference for scholars and engineers.

Methods:
This paper reviews various representative patents related to ball bearings in principal aspects,
such as lubrication, sealing, temperature, vibration, noise, and intelligence.

Results :
Through retracing the characteristics of different types of ball bearings, the main existing
problems in the current situation are summarized and analyzed. The future development of patents
on the structure of ball bearing is discussed.

Conclusion:
The structural improvement of ball bearing is conducive to the development of bearing
technology. Ball bearings with characteristics of simple structure, intelligence and integration will
have a good prospect in the future.
Toxicity and Tolerability of 177Lu-DOTA-TATE PRRT with a Modified Administered
Activity Protocol in NETs of Variable Origin – A Phase 2 Registry
Study
Authors: Khatami Alireza , Sistani Golmehr , Sutherland Duncan E. K. , DeBrabandere Sarah , Reid Robert H. , Laidley David T. 
Published: September 2021

Background:
Peptide receptor radionuclide therapy (PRRT) has been recently approved
for advanced, metastatic, or progressive neuroendocrine tumors (NETs).

Objectives:
This study reports the adverse events (AEs) observed with patient-tailored administered
activity.

Methods:
Fifty-two PRRT naive patients were treated with 177Lu-DOTATATE. The administered
activity ranges between 2.78 and 5.55 GBq/cycle using the patient's unique characteristics (age,
symptoms, blood work, and biomarkers).

Results:
The protocol was well tolerated with the overwhelming majority of participants being forty-
six (88%), completing all 4 induction therapy cycles. The median cumulative administered activity
was 19.6 GBq (ranged 3.8-22.3 GBq). A total of 42/52 (81%) reported at least one symptom,
and 43/52 (83%) had evidence of biochemical abnormality at enrollment that would meet grade 1
or 2 criteria for AEs. These symptoms only slightly increase with treatment to 50/52 (96%) and
51/52 (98%), respectively. The most common symptoms were mild fatigue (62%), shortness of
breath (50%), nausea (44%), abdominal pain (38%), and musculoskeletal pain (37%). The most
common biomarker abnormalities were mild anemia (81%), reduced estimated glomerular filtration
rate (eGFR) (58%), increased alkaline phosphatase (ALP) (50%), and leukopenia (37%). Of
critical importance, no 177Lu-DOTATATE related grade 3 or 4 AEs were observed.

Conclusion:
Tailoring the administered activity of 177Lu-DOTATATE to the individual patient
with a variety of NETs is both safe and well-tolerated. No patient developed severe grade 3 or 4
AEs. Most patients exhibit symptoms or biochemical abnormality before treatment and this only
slightly worsens following induction therapy.
Evaluation of Changes in Depression, Anxiety, and Social Anxiety Using Smartphone Sensor Features: Longitudinal Cohort Study
Authors: Meyerhoff Jonah , Liu Tony , Kording Konrad P , Ungar Lyle H , Kaiser Susan M , Karr Chris J , Mohr David C 
Published: September 2021

Background
The assessment of behaviors related to mental health typically relies on self-report data. Networked sensors embedded in smartphones can measure some behaviors objectively and continuously, with no ongoing effort.

Objective
This study aims to evaluate whether changes in phone sensor–derived behavioral features were associated with subsequent changes in mental health symptoms.

Methods
This longitudinal cohort study examined continuously collected phone sensor data and symptom severity data, collected every 3 weeks, over 16 weeks. The participants were recruited through national research registries. Primary outcomes included depression (8-item Patient Health Questionnaire), generalized anxiety (Generalized Anxiety Disorder 7-item scale), and social anxiety (Social Phobia Inventory) severity. Participants were adults who owned Android smartphones. Participants clustered into 4 groups: multiple comorbidities, depression and generalized anxiety, depression and social anxiety, and minimal symptoms.

Results
A total of 282 participants were aged 19-69 years (mean 38.9, SD 11.9 years), and the majority were female (223/282, 79.1%) and White participants (226/282, 80.1%). Among the multiple comorbidities group, depression changes were preceded by changes in GPS features (Time: r=−0.23, P=.02; Locations: r=−0.36, P<.001), exercise duration (r=0.39; P=.03) and use of active apps (r=−0.31; P<.001). Among the depression and anxiety groups, changes in depression were preceded by changes in GPS features for Locations (r=−0.20; P=.03) and Transitions (r=−0.21; P=.03). Depression changes were not related to subsequent sensor-derived features. The minimal symptoms group showed no significant relationships. There were no associations between sensor-based features and anxiety and minimal associations between sensor-based features and social anxiety.

Conclusions
Changes in sensor-derived behavioral features are associated with subsequent depression changes, but not vice versa, suggesting a directional relationship in which changes in sensed behaviors are associated with subsequent changes in symptoms.
MANAJEMEN SENI PERTUNJUKAN DI SANGGAR PUTI LIMO JURAI KOTA BUKITTINGGI
Authors: Pradita Tiaranti Dwi , Darmawati Darmawati , Mansyur Herlinda 
Published: September 2021

AbstractThe research aims to describe the Management of the performing arts in the workshop of Puti Limo Jurai Bukittinggi. Type of this research is descriptive research using qualitative methods. The main instrument in this study is the researchers themselves and supporting instruments such as assisted with writing instruments and cameras. The type of the data in the research is the primary data and secondary data. Engineering data collection done by the study of librarianship, observation/observation, interview and documentation. Technique of data analysis performed with the measures include: the reduction of the data, the presentation of data, conclusions and make a report. The results showed that Sangar Puti Limo Jurai still retain cultural values in the performing arts. As an organization that is engaged in the arts with a democratic system, where all the decisions taken based on the results of the mutual agreement. All the process is carried out by management as good as possible. System performance or the workings of the organization performing arts at Sanggar Puti Limo Jurai belongs to the semi professional performing arts organizations because the Sanggar Puti Limo has been working with the Kings ' management approach, both in terms of function or process. In terms of personal profession, and the members of the Sanggar Puti Limo Emblem also has a profession other than the workers of art. But in terms of their ethics remain subject to rules that have been set.Keywords: performing arts management
HUBUNGAN ANTARA KECERDASAN EMOSIONAL DENGAN HASIL BELAJAR SENI MUSIK KELAS XI SMA NEGERI 1 UJUNGBATU
Authors: Thania Aidha , Kadir Tulus Handra 
Published: September 2021

Abstract This article aimed to determine the relationship between emotional intelligence and Music Art Learning Outcomes of the class IX in Senior High School 1 Ujungbatu. Type of research was quantitative research. The forms of research instrument were questionnaires and documentation. The types of data in this study were both primary and secondary. Techniques of data collection were done by giving questionnaire and documentation. Data analysis was done in several stages, namely test requirements analysis and hypothesis testing. Based on the results of the study, the contribution coefficient between emotional intelligence and learning outcomes is obtained at 23.74%. From the data analysis test, it is found that the data is normal and homogeneous. The test result is at the significance level of α 0.05 (95% of confidence level) obtained a value of rcount = 0.4878 and rtable = 0.220 so that it is obtained rcount> rtable (0.4878> 0.220). This is reinforced by the results of the significance test which shows tcount = 4.9351 and ttable = 1.990 so that tcount> ttable (4.9351> 1.990) is obtained. Thus H0 is rejected and H1 is accepted which means that there is a positive and significant relationship between emotional intelligence and the Music Art Learning outcomes of the class XI in Senior High School 1 Ujungbatu. Keywords: Emotional Intelligence, Learning Outcomes
HUBUNGAN PELATIH TERHADAP KREATIVITAS SISWA DALAM PENGEMBANGAN DIRI SENI TARI DI SMP PEMBANGUNAN LABORATORIUM UNP
Authors: Trinanda Reza , Indrayuda Indrayuda 
Published: September 2021

Abstract This article aims to find out and describe the trainer's relationship to the students ' creativity in the development of dance art in junior high School of UNP. This type of research is a descriptive study that produces Qualitative data. The main instrument in this research is its own researchers. Data collection techniques are conducted by way of library studies, observation and documentation. The stage for analyzing data is to reduce data, data presentation and withdrawal of conclusions. The results showed that the activities of self-development in SMP UNP Laboratory development do not have a regular trainer and have different strategies and methods. The impact is that students lack the ability to develop patterns of motion, students feel corner and not confident if unable to mimic the techniques taught by the trainer, as well as students do not freely explore and express themselves. Therefore, the idea arises to see how the technique, and expression of the students in the dance of the Pasambahan, which has been given by his trainer. Keywords: relationship coach, creativity students self development Dance art