bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Rasio Profitabilitas, Rasio Likuiditas, Pertumbuhan Perusahaan Terhadap Opini Audit Going Concern
Authors: Kimberli Kimberli , Kurniawan Budi 
Published: November 2021

Abstract
The problems that will be discussed in this journal are regarding the relationship between Profitability Ratios, Liquidity Ratios and Company Growth on Audit Delay. The research method used in this study uses secondary data. The population in this study is all Real Estate companies and the Property sub-sector registered on the BEI which are listed on the Indonesia Stock Exchange in 2017, 2018, 2019 and 2020. The sampling method in this study is purposive sampling. The criteria for companies that are sampled are companies that publish audited financial statements for four consecutive years and use the rupiah currency, so that the total number of samples in this study is 165 data. The independent variables in this study are Profitability Ratios, Liquidity Ratios and Company Growth. The dependent variable in this study is audit delay. The data analysis technique used is the Logistics Regression Test with the use of Software Eviews 10. The results of the analysis show that profitability has no significant effect on going concern audit opinion. Meanwhile, company growth and liquidity have no effect on going concern audit opinion.
Keywords: Going Concern Opinion, Profitability, Liquidity, and Company Growth
STRATEGI PERCEPATAN FUNGSIONALISASI SENTRA KELAUTAN PERIKANAN TERPADU NATUNA
Authors: Tri Wiji Nurani  , Wawan Oktariza  , Taryono  , Wini Trilaksani  , Luky Adrianto  , Mubariq Ahmad  , Umi Muawanah  , Christy Desta Pratama  
Published: November 2021

Pemerintah Indonesia telah mengeluarkan Inpres No.7/2016 yang ditujukan untuk percepatan pembangunan sektor perikanan. Natuna merupakan salah satu lokasi yang ditetapkan sebagai Sentra Kelautan Perikanan Terpadu (SKPT). Tujuan penelitian adalah menyusun strategi bagi percepatan fungsionalisasi SKPT Natuna. Kajian diawali melalui analisis situasi terhadap keberadaaan SKPT Natuna untuk dapat mengidentifikasi peluang dan tantangan, dilanjutkan dengan memberikan rekomendasi langkah-langkah strategis bagi percepatan fungsionalisasi SKPT Natuna. Hasil penelitian dapat diidentifikasi peluang dan permasalahan untuk percepatan fungsionalisi SKPT Natuna, yaitu potensi sumberdaya ikan pelagis dan demersal memiliki peluang besar untuk dimanfaatkan dan adanya peluang ekspor produk segar untuk ikan demersal. Permasalahan yang dihadapi diantaranya yaitu, usaha penangkapan ikan merupakan usaha skala kecil dengan pengetahuan dan keterampilan nelayan rendah, tempat pendaratan ikan tersebar di beberapa lokasi, terbatasnya ketersediaan es untuk melaut, usaha pengolahan ikan masih skala rumah tangga dan terbatas pada olahan tradisional, terbatasnya kapasitas tenaga kerja, mahalnya biaya pengemasan, dan terbatasnya aksesibilitas untuk pemasaran. Langkah-langkah strategis yang dapat dilakukan yaitu optimalisasi pemanfaatan sumberdaya ikan pelagis dan demersal melalui peningkatan keterampilan nelayan, peningkatan armada penangkapan yang dikendalikan dengan perizinan dan pendataan, serta perlunya perencanaan secara terintegrasi pengembangan industri penangkapan, pengolahan dan pemasaran.
Kata kunci: fungsionalisasi SKPT, Natuna, peluang, permasalahan, strategi
Determinants of seizure outcome after resective surgery following stereoelectroencephalography
Authors: Bulacio Juan C. , Bena James , Suwanpakdee Piradee , Nair Dileep , Gupta Ajay , Alexopoulos Andreas , Bingaman William , Najm Imad 
Published: November 2021

OBJECTIVE
The aim of this study was to investigate seizure outcomes after resective epilepsy surgery following stereoelectroencephalography (SEEG), including group characteristics, comparing surgical and nonsurgical groups and assess predictors of time to seizure recurrence.

METHODS
Clinical and EEG data of 536 consecutive patients who underwent SEEG at Cleveland Clinic Epilepsy Center between 2009 and 2017 were reviewed. The primary outcome was defined as complete seizure freedom since the resective surgery, discounting any auras or seizures that occurred within the 1st postoperative week. In addition, the rate of seizure freedom based on Engel classification was determined in patients with follow-up of ≥ 1 year. Presumably significant outcome variables were first identified using univariate analysis, and Cox proportional hazards modeling was used to identify outcome predictors.

RESULTS
Of 527 patients satisfying study criteria, 341 underwent resective surgery. Complete and continuous seizure freedom after surgery was achieved in 55.5% of patients at 1 year postoperatively, 44% of patients at 3 years, and 39% of patients at 5 years. As a secondary outcome point, 58% of patients achieved Engel class I seizure outcome for at least 1 year at last follow-up. Among surgical outcome predictors, in multivariate model analysis, the seizure recurrence rate by type of resection (p = 0.039) remained statistically significant, with the lowest risk of recurrence occurring after frontal and temporal lobe resections compared with multilobar and posterior quadrant surgeries. Patients with a history of previous resection (p = 0.006) and bilateral implantations (p = 0.023) were more likely to have seizure recurrence. The absence of an MRI abnormality prior to resective surgery did not significantly affect seizure outcome in this cohort.

CONCLUSIONS
This large, single-center series shows that resective surgery leads to continuous seizure freedom in a group of patients with complex and severe pharmacoresistant epilepsy after SEEG evaluation. In addition, up to 58% of patients achieved seizure freedom at last follow-up. The authors’ results suggest that SEEG is equally effective in patients with frontal and temporal lobe epilepsy with or without MRI identified lesions.
Microsurgical approaches to the cerebellar interpeduncular region: qualitative and quantitative analysis
Authors: Serrato-Avila Juan Leonardo , Paz Archila Juan Alberto , Costa Marcos Devanir Silva da , Rocha Paulo Ricardo , Marques Sergio Ricardo , Moraes Luis Otavio Carvalho de , Cavalheiro Sergio , Yağmurlu Kaan , Lawton Michael T. , Chaddad-Neto Feres 
Published: November 2021

OBJECTIVE
The cerebellar interpeduncular region (CIPR) is a gate for dorsolateral pontine and cerebellar lesions accessed through the supracerebellar infratentorial approach (SCITa), the occipital transtentorial approach (OTa), or the subtemporal transtentorial approach (STa). The authors sought to compare the exposures of the CIPR region that each of these approaches provided.

METHODS
Three approaches were performed bilaterally in eight silicone-injected cadaveric heads. The working area, area of exposure, depth of the surgical corridor, length of the interpeduncular sulcus (IPS) exposed, and bridging veins were statistically studied and compared based on each approach.

RESULTS
The OTa provided the largest working area (1421 mm2; p < 0.0001) and the longest surgical corridor (6.75 cm; p = 0.0006). Compared with the SCITa, the STa provided a larger exposure area (249.3 mm2; p = 0.0148) and exposed more of the length of the IPS (1.15 cm; p = 0.0484). The most bridging veins were encountered with the SCITa; however, no significant differences were found between this approach and the other approaches (p > 0.05).

CONCLUSIONS
To reach the CIPR, the STa provided a more extensive exposure area and more linear exposure than did the SCITa. The OTa offered a larger working area than the SCIT and the STa; however, the OTa had the most extensive surgical corridor. These data may help neurosurgeons select the most appropriate approach for lesions of the CIPR.
Predictors for time to awake in patients undergoing awake craniotomies
Authors: Lai Yen-Mie , Boer Christa , Eijgelaar Roelant S. , van den Brom Charissa E. , de Witt Hamer Philip , Schober Patrick 
Published: November 2021

OBJECTIVE
Awake craniotomies are often characterized by alternating asleep-awake-asleep periods. Preceding the awake phase, patients are weaned from anesthesia and mechanical ventilation. Although clinicians aim to minimize the time to awake for patient safety and operating room efficiency, in some patients, the time to awake exceeds 20 minutes. The goal of this study was to determine the average time to awake and the factors associated with prolonged time to awake (> 20 minutes) in patients undergoing awake craniotomy.

METHODS
Records of patients who underwent awake craniotomy between 2003 and 2020 were evaluated. Time to awake was defined as the time between discontinuation of propofol and remifentanil infusion and the time of extubation. Patient and perioperative characteristics were explored as predictors for time to awake using logistic regression analyses.

RESULTS
Data of 307 patients were analyzed. The median (IQR) time to awake was 13 (10–20) minutes and exceeded 20 minutes in 17% (95% CI 13%–21%) of the patients. In both univariate and multivariable analyses, increased age, nonsmoker status, and American Society of Anesthesiologists (ASA) class III versus II were associated with a time to awake exceeding 20 minutes. BMI, as well as the use of alcohol, drugs, dexamethasone, or antiepileptic agents, was not significantly associated with the time to awake.

CONCLUSIONS
While most patients undergoing awake craniotomy are awake within a reasonable time frame after discontinuation of propofol and remifentanil infusion, time to awake exceeded 20 minutes in 17% of the patients. Increasing age, nonsmoker status, and higher ASA classification were found to be associated with a prolonged time to awake.
When can we expect global sagittal alignment to reach a stable value following cervical deformity surgery?
Authors: Lafage Renaud , Smith Justin S. , Sheikh Alshabab Basel , Ames Christopher , Passias Peter G. , Shaffrey Christopher I. , Mundis Gregory , Protopsaltis Themistocles , Gupta Munish , Klineberg Eric , Kim Han Jo , Bess Shay , Schwab Frank , Lafage Virginie , _ _ 
Published: November 2021

OBJECTIVE
Cervical deformity (CD) is a complex condition with a clear impact on patient quality of life, which can be improved with surgical treatment. Previous study following thoracolumbar surgery demonstrated a spontaneous and maintained improvement in cervical alignment following lumbar pedicle subtraction osteotomy (PSO). In this study the authors aimed to investigate the complementary questions of whether cervical alignment induces a change in global alignment and whether this change stabilizes over time.

METHODS
To analyze spontaneous changes, this study included only patients with at least 5 levels remaining unfused following surgery. After data were obtained for the entire cohort, repeated-measures analyses were conducted between preoperative baseline and 3-month and 1-year follow-ups with a post hoc analysis and Bonferroni correction. A subanalysis of patients with 2-year follow-up was performed.

RESULTS
One-year follow-up data were available for 121 of 168 patients (72%), and 89 patients had at least 5 levels remaining unfused following surgery. Preoperatively there was a moderate anterior cervical alignment (C2–7, −7.7° [kyphosis]; T1 slope minus cervical lordosis, 37.1°; cervical sagittal vertebral axis [cSVA], 37 mm) combined with a posterior global alignment (SVA, −8 mm) with lumbar hyperextension (pelvic incidence [PI] minus lumbar lordosis [LL] mismatch [PI-LL], −0.6°). Patients underwent a significant correction of the cervical alignment (median ΔC2–7, 13.6°). Simultaneously, PI-LL, T1 pelvic angle (TPA), and SVA increased significantly (all p < 0.05) between baseline and 3-month and 1-year follow-ups. Post hoc analysis demonstrated that all of the changes occurred between baseline and 3 months. Subanalysis of patients with complete 2-year follow-up demonstrated similar results, with stable postoperative thoracolumbar alignment achieved at 3 months.

CONCLUSIONS
Correction of cervical malalignment can have a significant impact on thoracolumbar regional and global alignment. Peak relaxation of compensatory mechanisms is achieved by the 3-month follow-up and tends to remain stable. Subanalysis with 2-year data further supports this finding. These findings can help to identify when the results of cervical surgery on global alignment can be best evaluated.
In vivo comparison of the degradation and osteointegration properties of micro-arc oxidation-coated Mg-Sr and Mg-Ca alloy scaffolds
Authors: Sun Hongyu , Wang Yuefei , Sun Chu , Yu Haiming , Xi Zheng , Liu Na , Zhang Nan 
Published: November 2021

BACKGROUND: Magnesium (Mg) alloy have biodegradation and mechanical properties that are similar to those of human bone, making it a promising candidate material for inclusion in implantable medical devices. OBJECTIVE: The osteointegration effect of Mg alloy scaffolds with different corrosion rates were studied and evaluated in large bone defect models. METHOD: Mg–Sr and Mg–Ca alloy scaffolds with a 20-μm Micro-arc oxidation (MAO) coating were used to repair critical bone defects for subsequent assessment of each alloy’s degradation and osteointegration by X-ray, Micro-CT, fluorescence and histological examination. RESULTS: At 12 weeks post-implantation, each defect was found to be effectively reconstructed by either of the Mg alloys based on X-ray and Micro-CT images. The corrosion rate (CR) of each Mg alloy – as calculated based on micro-computed tomography information – demonstrated that the MAO coating could provide effective protection for only 4 weeks post-surgery. From weeks 8 to 12, the CR of the Mg–Ca alloy scaffold increased from 1.34 ± 0.23 mm/y to 1.57 ± 0.16 mm/y. In contrast, the CR of the Mg–Sr alloy scaffold decreased from 0.58 ± 0.14 mm/y to 0.54 ± 0.16 mm/y. However, fluorescence and histological examination revealed more mature, closely and regularly arranged newborn osteocytes at the Mg–Ca scaffold-fracture interface e from weeks 8 to 12 after surgery. CONCLUSION: The Mg–Sr scaffold was more corrosion resistant and the Mg–Ca scaffold yielded a better overall repair, which indicates that the CR of magnesium alloys matches the rate of new bone formation and is the key to repair bone defects as a bone substitute.
КОЛАБОРАТИВНЕ НАВЧАННЯ НА ЗАНЯТТЯХ З ІНОЗЕМНОЇ МОВИ У ВИЩОМУ НАВЧАЛЬНОМУ ЗАКЛАДІ: ПЕРЕВАГИ ТА МОЖЛИВІ ВИКЛИКИ
Authors: ПІЛІШЕК Світлана 
Published: November 2021

Стаття містить узагальнений досвід застосування колаборативного навчання під час викладання англійської мови у Хмельницькому національному університету з метою зокрема забезпечення інтерактивності практичних занять, забезпечення студентоцентрованості навчального процесу, розвитку не лише іноземномовної комунікативної компетентності, але й іншої низки вмінь та навичок, необхідних для успішної майбутньої професійної діяльності студентів тощо. Установлено витоки походження активного методу колаборативного навчання та визначено його сутність і алгоритм застосування викладачем. Комунікативний підхід до викладання іноземної мови станом на сьогодні вважається одним із найбільш ефективних. Відтак залучення колаборативного навчання, котре передбачає взаємодію між учасниками групи під час вирішення професійнооріє нтованих ситуацій засобами іноземної мови, розглядається як ефективний, мотивуючий прийом, котрий дозволяє також вибудовувати власну індивідуальну траєкторію навчання для студентів. Актуальність більш широкого використання методу колаборативного навчання під час занять з іноземної мови підкреслюється і тим, що цей метод сприяє формуванню та удосконаленню низки компетенцій студентів, включно із комунікативною, котра є ключовою у навчанні іноземних мов. Хоча роль викладача під час колаборативного навчання набуває змісту спостерігача, фасилітатора тощо, а спілкування між викладачем та студентами реалізується за моделлю суб’єкт-суб’єктної взаємодії,викладачу варто бути готовим до можливих викликів. Аби ретельно спланувати та успішно реалізувати сценарій колаборативного навчання, викладачеві варто розвинути та/або удосконалити необхідні для цього компетентності (здатність до планування, до моніторингу та підтримки груп, здатність до узагальнення та рефлексії).
Qualidade do sono dos profissionais da saúde que trabalham em regime de plantão noturno: revisão sistemática da literatura
Authors: Monteiro Daniel Lucas Costa , Conceição Alicia Renata Sales da , Brito Gabriel Pinheiro , Lima Kelyane Oliveira , Tavares Marcelo Luiz Couto , Cunha Adenard Francisco Cleophas 
Published: November 2021

Objetivo: Elaborar uma revisão sistemática de literatura analisando a qualidade do sono de profissionais da saúde em regime de plantão noturno. Metodologia: Realizou-se a revisão sistemática de literatura, com pesquisa nas bases de dados eletrônicas PubMed, Biblioteca Virtual em Saúde, SCIELO. Foram incluídos estudos que abordaram a qualidade do sono de profissionais da saúde que trabalham em regime de plantão noturno; publicados a partir de 2016 a 2021 e disponibilizados nas bases de dados, nos idiomas inglês e português; com participantes de idade superior a 18 anos. Foram excluídos artigos de revisão; artigos cujos participantes não eram profissionais da saúde e os que possuíam diagnóstico prévio de distúrbios do sono. Resultados: Do total de 3.540 trabalhos encontrados nas bases de dados eletrônicas, 26 eram referentes a Scielo, 1.523 foram encontrados na PubMed e 1.991 na BVS. Foram excluídos 3.464 artigos e, a partir dos 76 estudos selecionados, realizou-se a busca manual, totalizando 21 artigos. Discussão: O excesso de atividades e altas jornadas de trabalho, além das alterações do sono podem contribuir em problemáticas que afetem a vida social, psicológica e fisiológica dos trabalhadores da saúde em regime de plantão noturno, afetando negativamente não só os profissionais, mas também o ambiente de trabalho, a equipe e os próprios pacientes. Conclusão: Os profissionais que mais sofrem conflitos diários em suas jornadas de trabalho são os que os realizam em regime de plantão hospitalar noturno, porém podem obter alívio das consequências a partir de elaboração de alternativas de escala.
The Efficacy Comparison Between Guan-Fu Base A Hydrochloric Injection vs. Propafenone Hydrochloric Injection in the Treatment of Arrhythmia: Systemic Review and Meta-Analysis
Authors: Song Jinming , Tang Yao , Gao Chao , Hou Xiaofeng , Liu Xinyue , Xu Zongpei 
Published: November 2021

Objective: To determine using a systematic assessment and meta-analysis if GFA injection is an appropriate substitute of propafenone for arrhythmic.Design: Conduct a systematic review and meta-analysis of randomized controlled trials.Data Source: PubMed, Web of Science, Cochrane Library, Embase, Wan-Fang Database, VIP, CNKI, and Sino Med from their inception to 7 March 2021.Eligibility Criteria for Selecting Studies: Inclusion of randomized controlled trials, which draws a comparison between GFA and propafenone. Evaluation of study integrity and conducted an extraction of independent data.Main Outcome Measure: Efficacy for supraventricular tachycardia, it is considered effective if it is reversed within 40 min (without considering recurrence); for premature ventricular beats, if they are reduced by more than 50% within 6 h.Results: Included in this current study are 1,294 research subjects pooled from 14 clinical studies. From the pooled assessment, GFA is demonstrated to be the equivalent of propafenone regarding the potency of effectiveness for tachycardia (RR = 1.11, 95% CI: 0.96, 1.28, P = 0.15). The subset analysis indicated that GFA has a better effect on premature ventricular beats (RR = 1.35, 95% CI: 1.07, 1.70, P = 0.01) and a similar effect on supraventricular tachycardia (RR = 1.07, 95% CI: 0.98, 1.12, P = 0.21). GFA effectiveness is lesser than propafenone in the case of mean converting time (WMD = −1.18, 95% CI: −2.30, −0.07, P = 0.04), systolic blood pressure (WMD = −3.53, 95% CI: −6.97, −0.09, P = 0.04), and QRS complex (WMD = −3.82, 95% CI: −6.96, −0.69, P = 0.02). Both GFA and propafenone have identical effects for diastolic blood pressure, heart rate, P-R interval, and QTc interval.Conclusion: A meta-analysis of RCTs was performed across 14 clinical trials, whereby 1,294 patients are used as research subjects. From the results, it is revealed that the effect exhibited by GFA injection is similar to the propafenone injection when treating premature ventricular beats or supraventricular tachycardia. Nevertheless, in certain academic disciplines, it was found that GFA is safer and beneficial compared to propafenone. Based on facts from relevant studies, GFA is deemed applicable during clinical practice.Systematic Review Registration:https://www.inplasy.com/inplasy-2021-3-0077/, identifier: INPLASY202130077.
The Prognostic Value of Cardiac Biomarkers and Echocardiography in Critical COVID-19
Authors: Zwaenepoel Bert , Dhont Sebastiaan , Hoste Eric , Gevaert Sofie , Schaubroeck Hannah 
Published: November 2021

Background: Early risk stratification is crucial in critically ill COVID-19 patients. Myocardial injury is associated with worse outcome. This study aimed to evaluate cardiac biomarkers and echocardiographic findings in critically ill COVID-19 patients and to assess their association with 30-day mortality in comparison to other biomarkers, risk factors and clinical severity scores.Methods: Prospective, single-center, cohort study in patients with PCR-confirmed, critical COVID-19. Laboratory assessment included high sensitive troponin T (hs-cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) on admission to ICU: a hs-cTnT ≥ 14 pg/mL and a NT-proBNP ≥ 450 pg/mL were considered as elevated. Transthoracic echocardiographic evaluation was performed within the first 48 h of ICU admission. The primary outcome was 30-day all-cause mortality. Predictive markers for mortality were assessed by ROC analysis and cut-off values by the Youden Index.Results: A total of 100 patients were included. The median age was 63.5 years, the population was predominantly male (66%). At the time of ICU admission, 47% of patients had elevated hs-cTnT and 39% had elevated NT-proBNP. Left ventricular ejection fraction was below 50% in 19.1%. Elevated cardiac biomarkers (hs-cTnT P-value &lt; 0.001, NT-proBNP P-value = 0.001) and impaired left ventricular function (P-value = 0.011) were significantly associated with mortality, while other biomarkers (D-dimer, ferritin, C-reactive protein) and clinical scores (SOFA) did not differ significantly between survivors and non-survivors. An optimal cut-off value to predict increased risk for 30-day all-cause mortality was 16.5 pg/mL for hs-cTnT (OR 8.5, 95% CI: 2.9, 25.0) and 415.5 pg/ml for NT-proBNP (OR 5.1, 95% CI: 1.8, 14.7).Conclusion: Myocardial injury in COVID-19 is common. Early detection of elevated hs-cTnT and NT-proBNP are predictive for 30-day mortality in patients with critical COVID-19. These markers outperform other routinely used biomarkers, as well as clinical indices of disease severity in ICU. The additive value of routine transthoracic echocardiography is disputable and should only be considered if it is likely to impact therapeutic management.