bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient removal of crystal violet dye from aqueous solutions using sodium hydroxide-modified avocado shells: kinetics and isotherms modeling
Authors: Ait Haki Mohamed , Imgharn Abdelaziz , Aarab Nouh , Hsini Abdelghani , Essekri Abdelillah , Laabd Mohamed , El Jazouli Habiba , Elamine Maria , Lakhmiri Rajae , Albourine Abdallah 
Published: October 2021

Abstract
The main objective of this study is to optimize a new composite for the depollution of contaminated water. The sodium hydroxide-modified avocado shells (NaOH-AS) were firstly prepared, characterized by field-emission-scanning-electron-microscopy (FE-SEM), X-ray energy dispersive spectroscopy (EDS) and Fourier transforms infrared (FT-IR) spectroscopy, and applied for efficient removal of crystal violet dye (CV) in wastewater. In addition, the adsorption in a batch system of CV dye on the NaOH-AS material was studied. Therefore, we accomplished a parametric study of the adsorption by studying the effect of several important parameters on the decolorizing power of the used material, namely, initial pH, contact time, initial CV dye concentration, temperature, and the ionic strength effect on the CV dye adsorption process were systematically assessed. The highest adsorption efficiency of CV dye (&gt;96.9%) by NaOH-AS was obtained at pH &gt;8. The pseudo-second-order kinetic model gave the best description of the adsorption kinetic of CV dye on the AS and NaOH-AS adsorbents. In addition, the mass transfer of CV dye molecules from the solution to the adsorbent surface occurred in three sequential stages (boundary layer diffusion, intraparticle diffusion and adsorption equilibrium). The adsorption isotherm data were best fitted with the Freundlich model. The adsorption capacity of AS increased from 135.88 to 179.80 mg g−1 after treatment by 1 M NaOH. The thermodynamic study showed that CV dye adsorption onto NaOH-AS was an exothermic and feasible process. The electrostatic interactions acted as the only forces governing the CV adsorption mechanism. The NaOH-AS demonstrated a satisfactory reusability. Therefore, we can state that the as-developed NaOH-AS material has a potential application prospect as an efficient adsorbent for CV dye from wastewaters.
Soft Power In the politics and reform process of China (1978-1992)
Authors: Saeed Hiwa Aziz , Tawfeeq Ayub Zahir 
Published: October 2021

China is one of the rare world events that almost every country in the world has unforgettable. This may become the basis for the development of economic, political and ideological methods within a short and precise time frame. China has developed from a primitive agricultural country such as life cycle, medical care, education and local standard management to a country with strong economic, scientific and technological strength. Regional and international norms have transformed China from a ruined and despised country into a valuable international political force. While influencing the international and regional political equations, it also puts the world’s powerful countries first. This is the application of soft power in politics and international relations, enabling them to obtain basic materials for establishing and strengthening local politics and conducting social, scientific, military, and technological reforms while voluntarily joining the bondage. And closed the door on a regional and international scale. Establish standards and establish opaque diplomatic relations with different continents. Through these standards, they can ensure the market for their products and provide the necessary energy for the production process they initiate.
Boundary Objects as Dialogical Learning Accelerators for Social Change in Design for Health: Systematic Review
Authors: Terlouw Gijs , Kuipers Derek , Veldmeijer Lars , van 't Veer Job , Prins Jelle , Pierie Jean-Pierre 
Published: October 2021

Background
Boundary objects can add value for innovative design and implementation research in health care through their organizational focus and the dynamic structure between ill-structured and tailored use. However, when innovation is approached as a boundary object, more attention will need to be paid to the preimplementation phase. Research and design thinking pay attention to the preimplementation stage but do not have a social or organizational focus per se. The integration of boundary objects in design methodologies can provide a more social and organizational focus in innovative design projects by mapping out the mechanisms that occur at boundaries during design. Four dialogical learning mechanisms that can be triggered at boundaries have been described in the literature: identification, coordination, reflection, and transformation. These mechanisms seem suitable for integration in innovative design research on health.

Objective
Focusing on innovation in health, this study aims to find out whether the different learning mechanisms can be linked to studies on health innovation that mention boundary objects as a concept and assess whether the related mechanisms provide insight into the stage of the design and implementation or change process.

Methods
The following 6 databases were searched for relevant abstracts: PubMed, Scopus, Education Resources Information Center, PsycINFO, Information Science and Technology Abstracts, and Embase. These databases cover a wide range of published studies in the field of health.

Results
Our initial search yielded 3102 records; after removing the duplicates, 2186 (70.47%) records were screened on the title and abstract, and 25 (0.81%) papers were included; of the 13 papers where we identified 1 mechanism, 5 (38%) described an innovation or innovative project, and of the 12 papers where we identified more mechanisms, 9 (75%) described the development or implementation of an innovation. The reflective mechanism was not identified solely but was present in papers describing a more successful development or implementation project of innovation. In these papers, the predetermined goals were achieved, and the process of integration was relatively smoother.

Conclusions
The concept of boundary objects has found its way into health care. Although the idea of a boundary object was introduced to describe how specific artifacts can fulfill a bridging function between different sociocultural sites and thus have a social focus, the focus in the included papers was often on the boundary object itself rather than the social effect. The reflection and transformation mechanisms were underrepresented in the included studies but based on the findings in this review, pursuing to trigger the reflective mechanism in design, development, and implementation projects can lead to a more fluid and smooth integration of innovation into practice.
Prevalence and Temporal Trends Analysis of Screening and Diagnostic Instruments in Posttraumatic Stress Disorder: Text Mining Study
Authors: Zong Hui , Hu Binyang , Han Yang , Li Zuofeng , Zhang Xiaoyan 
Published: October 2021

Background
Various instruments for patient screening and diagnosis have been developed for and applied in posttraumatic stress disorder (PTSD).

Objective
This study comprehensively investigates the prevalence and temporal trends of the most widely used instruments in PTSD-related studies.

Methods
A total of 1345 files of registered clinical trials from ClinicalTrials.gov and 9422 abstracts from the PubMed database from 2005 to 2020 were downloaded for this study. The instruments applied in clinical trials were manually annotated, and instruments in abstracts were recognized using exact string matching. The prevalence score of an instrument in a certain period was calculated as the number of studies divided by the number of instances of the instrument. By calculating the yearly prevalence index of each instrument, we conducted a trends analysis and compared the trends in index change between instruments.

Results
A total of 4178 instrument synonyms were annotated, which were mapped to 1423 unique instruments. In the 16 years from 2005 to 2020, only 10 instruments were used more than once per year; the 4 most used instruments were the PTSD Checklist, the Clinician-Administered PTSD Disorder Scale, the Patient Health Questionnaire, and the Beck Depression Inventory. There were 18 instruments whose yearly prevalence index score exceeded 0.1 at least once during the 16 years. The changes in trends and time points of partial instruments in clinical trials and PubMed abstracts were highly consistent. The average time duration of a PTSD-related trial was 1495.5 days or approximately 4 years from submission to ClinicalTrial.gov to publication in a journal.

Conclusions
The application of widely accepted and appropriate instruments can help improve the reliability of research results in PTSD-related clinical studies. With extensive text data obtained from real clinical trials and published articles, we investigated and compared the usage of instruments in the PTSD research community.
Nanoparticulate drug delivery systems: A revolution in design and development of drugs
Authors: Shukla Prashant , Sharma Shweta , Rao Padma 
Published: October 2021

The recent developments in nanoparticle-based drug formulations have been helping to address issues around treating challenging diseases. Nanoparticles come in different sizes but usually vary between 100nm to 500nm. For the past few years there has been research going on in the area of drug delivery using particulate delivery systems. Various drug molecules have been modified for both pharmacokinetic and pharmacodynamic properties using nanoparticles as physical approach. Various polymers have been used in the formulation of nanoparticles for drug delivery research to increase therapeutic benefit, while minimizing side effects. Here, we review various aspects of nanoparticle formulation, characterization, effect of their characteristics and their applications in delivery of drug molecules and therapeutic genes.
Keywords: nanoparticles, applications in delivery, Liposomes, Dendrimers
In-silico ADMET predicated Pharmacoinformatics of Quercetin-3-Galactoside, polyphenolic compound from Azadirachta indica, a sacred tree from Hill Temple in Alagarkovil Reserve Forest, Eastern Ghats, INDIA
Authors: Sabitha M. , Krishnaveni K. , Murugan M. , Basha A N , Pallan Gilse A , Kandeepan C. , Ramya S. , Jayakumararaj R. 
Published: October 2021

Quercetin (3,3′,4′,5,7-Pentahydroxyflavone) is the one among the bioactive secondary metabolite (BASM) in neem seed of Azadirachta indica A. Juss. Quercetin (Que) and its derivatives hold promising pharmacological effects. Antidiabetic, anti-inflammatory, antioxidant, antimicrobial, anti-Alzheimer’s, antiarthritic, cardiovascular, and wound-healing effects of Que have been extensively investigated, recently lot of work has been carried out on its anticancer activity against different cancer cell lines. Recently, in silico/ in vitro studies have demonstrated that Que interferes with different stages of coronavirus entry and replication cycle (PLpro, 3CLpro, and NTPase/helicase). Due to its pleiotropic effects in human health and disease and lack of systemic toxicity, Que and its derivatives could be tested for their efficacy on human target system in future clinical trials. In the present study, an attempt has been made to evaluate the physicochemical, druggable properties of Que from A. indica to prospect its ADMET properties.
Keywords: NEEM; Azadirachta indica; Quercetin; Pharmacoinformatics; ADMET; Drug-Likeness; Toxicology
ATT-Therapy Induced DRESS: A Case Report
Authors: Sri G Navya , Stanly Feba , Sarah Georgina , Bali Prasad , Dalal Varsha 
Published: October 2021

A severe adverse reaction called Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS syndrome), is usually described by eosinophilia, fever, swollen lymph nodes, severe skin rash and extensive systemic association. It is distinguished by a lengthy latency period, which is characteristic drug reaction with eosinophilia and systemic symptoms (DRESS). Formerly known as drug-induced delayed multi-organ hypersensitivity syndrome (DIDMOHS) or drug-induced hypersensitivity (DIHS). There are a variety of clinical symptoms associated with the syndrome yet it is still poorly understood. Drugs most commonly implicate in Anticonvulsants are the most common cause of DRESS syndrome, followed by sulfonamides and a variety of anti-inflammatory medications.Anti-tubercular therapy (ATT) is rarely associated with DRESS syndromeWe present the case of a 60-year-old female patient who had previously been treated with Anti-tubercular Therapy for Tubercular Meningitis (ATT).She was admitted to the hospital with presenting complaints of vomiting, burning micturition, fever associated with chills, generalized swelling and reddish skin all over the body including facial puffiness. The problem was successfully resolved by refraining from the offending medication and administering supportive care. Thus, the case illustrates the necessity of considering anti-tubercular drug reactions even when symptoms are delayed.
Keywords: Anti-tubercular Therapy (ATT), Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), Adverse drug reaction (ADR), Drug-induced, Systemic symptoms syndrome,
4D Printing: The Dawn of “Smart” Drug Delivery Systems and Biomedical Applications
Authors: Khan Ahmar , Iqbal Mir Javid , Amin Saima , Bilal Humaira , Bilquees , , Noor Aneeza , Mir Bushra , Kaur Mahak Deep 
Published: October 2021

With the approval of first 3D printed drug “spritam” by USFDA, 3D printing is gaining acceptance in healthcare, engineering and other aspects of life. Taking 3D printing towards the next step gives birth to what is referred to as “4D printing”. The full credit behind the unveiling of 4D printing technology in front of the world goes to Massachusetts Institute of Technology (MIT), who revealed “time” in this technology as the fourth dimension. 4D printing is a renovation of 3D printing wherein special materials (referred to as smart materials) are incorporated which change their morphology post printing in response to a stimulus. Depending upon the applicability of this technology, there may be a variety of stimuli, most common among them being pH, water, heat, wind and other forms of energy. The upper hand of 4D printing over 3D printing is that 3D printed structures are generally immobile, rigid and inanimate whereas 4D printed structures are flexible, mobile and able to interact with the surrounding environment based on the stimulus. This capability of 4D printing to transform 3D structures into smart structures in response to various stimuli promises a great potential for biomedical and bioengineering applications. The potential of 4D printing in developing pre-programmed biomaterials that can undergo transformations lays new foundations for enabling smart pharmacology, personalized medicine, and smart drug delivery, all of which can help in combating diseases in a smarter way. Hence, the theme of this paper is about the potential of 4D printing in creating smart drug delivery, smart pharmacology, targeted drug delivery and better patient compliance. The paper highlights the recent advancements of 4D printing in healthcare sector and ways by which 4D printing is doing wonders in creating smart drug delivery and tailored medicine. The major constraints in the approach have also been highlighted.
Keywords: 4D printing, smart, drug delivery system, patient compliance, biomaterials, tailored medicine
A Comprehensive Review on Natural Products as Chemical Penetration Enhancer
Authors: Das Sudip , Sen Gupta Koushik 
Published: October 2021

The drug delivery within the stratum corneum of the skin prevails a challenging area for the pharmaceutical field, especially to the formulation scientists. Several investigations revealed that the lipid domain, which is the integral component of the transport barrier, must be breached if it is to be delivered transdermally at an appropriate rate. In particular, transdermal drug delivery has intrigued researchers with multiple suggestions because multiple dosing or insufficient drug delivery or characteristics of various drugs often results in low therapeutic effects. The application of permeation or penetration enhancers may prolong the number of drugs that can be offered topically. The application of any natural permeation enhancer is innoxious over the artificial permeation enhancers. The natural permeation enhancers are investigated, so notably include essential oils, terpenes, terpenoids, fatty acid esters, etc., have a certain effect in the transdermal drug delivery system. Despite decades of investigation on the natural chemical penetration enhancer, the researchers could not establish the effectiveness of natural penetration enhancers clinically due to the lack of in vivo models. Several factors, like solubility, solvent selection, experimental models, etc., has restricted the application and development of natural penetration enhancers in topical drug delivery systems, especially in the patches. Therefore, further investigation needs to do on skin irritation to decide natural penetration enhancers controlling optimum enhancement effects with minimal skin irritation. This review gives a comprehensive literature survey on naturally obtained chemical penetration enhancers and their future possibilities.
Keywords: Topical Drug delivery system, Natural products, Penetration enhancer, Stratum corneum, In vivo models.
Concept of Busoore Labaniya (Acne Vulgaris) and its Management In Light of Unani System of Medicine
Authors: Anjum Sultana , Tabasum Ayesha , Manzoor Faisel , Faisal Mohammed Uwais 
Published: October 2021

Acne vulgaris is extremely common dermatological disorder, affecting more than 85% of adolescents and young adults. In western societies, acne vulgaris is a nearly universal skin disease afflicting 79% to 95% of the adolescent population. A recent systematic review of the epidemiology of acne across the world noted acne prevalence estimates ranging from just over 20% to over 95%. The greatest burden of acne globally is between the ﬁrst and third decade of life and almost certainly causes embarrassment, stigma, shame, guilt, and low self-esteem, which are likely to cause psychosocial problems. It is characterized by both inflammatory (papules, pustules and nodules) and non-inflammatory comedones (open and closed) lesions. In Unani system of medicine, acne vulgaris is termed as busoore labaniya that are whitish eruptions on the nose and face that represent milk droplets or frozen ghee (Roghan zard) due to Ma’dah sadidiyah or pus like morbid matter that is directed towards the skin for expulsion along with ghaleez bukharat. There are mentioned numerous single and compound formulations having Mujaffif and Muhallil properties for the management of Busoore Labaniya. The principle of treatment is aimed to removal of morbid matter, which is the actual culprit for the genesis of pathology leading to development of busoore labaniya. So there is need to explore the Unani concept of dermatoses. Present review paper is an attempt to highlight the possible management and preventive measures of acne vulgaris through Unani medicine.
Keywords: Busoore labaniya, Acne vulgaris, Unani system of medicine, Mujaffif and Muhallil.
Role and Efficacy of “Katankateriyadi Kwatha” in Patients of Madhumeha (Diabetes Mellitus Type 2): A Clinical Trial
Authors: Singh Vandana , Ram Bhuwal 
Published: October 2021

Madhumeha (Diabetes Mellitus) is a by-product of urbanization, proclaimed thousands of years back by Acharya Charaka. India has a high prevalence of diabetes which is increasing in number at an alarming rate. The introduction of oral hypoglycaemic drugs in modern therapeutics materialize to be a breakthrough in the treatment of Diabetes Mellitus initially but subsequently, it was experienced that most of the hypoglycaemic drugs were inadequately effective and were associated with many major side effects. To get rid of this problem, here we aimed to find out an effective and safe remedy to control the disease. This study is an Open-label, standard control, randomized and comparative clinical study with the 3-month assessment of the response of the trial drug “Katankateriyadi Kwatha” on the diabetic patients through subjective and objective parameters.
Keywords: Diabetes mellitus, Clinical study, Madhumeha, Katankateriyadi Kwatha.
In vitro anti-inflammatory and antimicrobial activity of Securidaca longepedunculata and Annona senegalensis hydro-alcoholic extract
Authors: Datagni G'massampou , Mouzou Aklesso Pouwelong , Metowogo Kossi , Afanyibo Yaovi-Gameli , Sadji Adodo , Eklu-Gadegbeku Kwashie 
Published: October 2021

Annona senegalensis and Securidaca longepedunculata are two plants traditionnaly used in inflammation and wounds infection treatment after snakebites.
This study aims to investigate the in vitro anti-inflammatory and antimicrobial activities of the hydroalcoholic extracts of Annona senegalensis and Securidaca longepedunculata.
Antimicrobial activity of the two plant extracts was examined against five bacterial strains with the well diffusion method and the inhibition zones diameters (IZD), minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined using the 96-well microplate dilution method. While antiinflammatory activity was assessed by the albumin denaturation method.
The results obtained showed that the hydroalcoholic extract of Annona senegalensis has antimicrobial property against Staphylococcus aureus (IZD=12.22 ± 0.24 mm, MIC=62.5 mg/mL, MBC=125 mg/mL) and against Pseudomonas aeruginosa (IZD=12.06 ± 0.06 mm, MIC=125 mg/mL, MBC=250 mg/mL). Securidaca longepedunculata also showed its antimicrobial activity against Staphylococcus aureus (IZD=12.03 ± 0.03 mm, MIC=125 mg/mL, MBC=250 mg/mL) and Candida albicans (IZD=12.12 ± 0.07 mm, MIC=62.5 mg/mL, MFC=125 mg/mL).
In the order hand, Annona senegalensis and Securidaca longepedunculata exhibited concentration-dependent anti-inflammatory activity by reducing significantly (p<0.001) the denaturation of BSA. In addition S. longepedunculata inhibited haemolysis significantly (p<0.001) more than Diclofenac sodium at 200 and 400 µg/mL.
Hence, it was concluded that Annona senegalensis and Securidaca longepedunculata possessed anti-inflammatory and antimicrobial properties and can be used in the treatment of inflammation and wounds infection after snakebites.
Keywords: Annona senegalensis, Securidaca longepedunculata, anti-inflammatory, antimicrobial, BSA.