bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeted Albumin Therapy Does Not Improve Short-Term Outcome in Hyponatremic Patients Hospitalized With Complications of Cirrhosis: Data From the ATTIRE Trial
Authors: China Louise , Freemantle Nick , Forrest Ewan , Kallis Yiannis , Ryder Stephen D. , Wright Gavin , O'Brien Alastair 
Published: September 2021

INTRODUCTION:
Patients with decompensated cirrhosis and hyponatremia have a poor prognosis. We investigated Albumin to Prevent Infection in Chronic Liver Failure trial data to determine whether targeted albumin infusions improved outcome in patients with hyponatremia at baseline.

METHODS:
We examined the interaction between targeted albumin and standard care for the composite primary end point, stratifying by baseline sodium ≥ and <130 mmol/L.

RESULTS:
Randomization to albumin was associated with a significant increase in sodium; however, there was no interaction between sodium category and treatment for the trial primary end point.

DISCUSSION:
Targeted intravenous albumin infusions increased serum sodium level in hospitalized hyponatremic patients with cirrhosis, but this did not improve outcome.
Novel bounds for causal effects based on sensitivity parameters on the risk difference scale
Authors: Sjölander Arvid , Hössjer Ola 
Published: September 2021

Abstract
Unmeasured confounding is an important threat to the validity of observational studies. A common way to deal with unmeasured confounding is to compute bounds for the causal effect of interest, that is, a range of values that is guaranteed to include the true effect, given the observed data. Recently, bounds have been proposed that are based on sensitivity parameters, which quantify the degree of unmeasured confounding on the risk ratio scale. These bounds can be used to compute an E-value, that is, the degree of confounding required to explain away an observed association, on the risk ratio scale. We complement and extend this previous work by deriving analogous bounds, based on sensitivity parameters on the risk difference scale. We show that our bounds can also be used to compute an E-value, on the risk difference scale. We compare our novel bounds with previous bounds through a real data example and a simulation study.
Broadband Internet and Income Inequality
Authors: Houngbonon Georges V. , Liang Julienne 
Published: September 2021

Abstract
Digital technologies like the Internet can affect income inequality through increased demand for employment in manual and abstract jobs and reduced demand for employment in routine jobs. In this paper, we combine city-level income distribution and jobs data with broadband data from France to investigate the impact of broadband Internet access on income inequality. Using an instrumental variable estimation strategy, we find that broadband Internet reduces income inequality through increased employment in manual jobs. These effects increase with the availability of skilled workers and are significant in cities with a large service sector or high-speed Internet access. Further, the diffusion of broadband Internet comes with relatively greater benefits in low-income cities compared to high-income cities. Several robustness checks support these findings.
Human Slip Assessment of Candidate Reference Surfaces for Walkway Tribometer Validation: An Update to Standard ASTM F2508
Authors: Blanchette Mark G. , Lee-Confer Jonathan , Brault John R. , Rutledge Bradley , Elkin Benjamin S. , Siegmund Gunter P. 
Published: September 2021

Abstract
Previous studies have reported on the concept of using human subjects to rank and differentiate walkway surfaces that vary in slipperiness. Surfaces identified as having different levels of slipperiness, based on the outcomes of human subject walking trials, are then used to validate tribometer slip resistance measurements. This concept was adopted in the development of ASTM F2508-11, Standard Practice for Validation and Calibration of Walkway Tribometers Using Reference Surfaces. Because of a depleting supply of the reference surfaces cited by ASTM F2508, new reference surfaces are needed. In this study, our objective was to assess new candidate reference surfaces to update the ASTM F2508-16, Standard Practice for Validation, Calibration, and Certification of Walkway Tribometers Using Reference Surfaces. One hundred and forty-eight human subjects walked across four ceramic-based tiles (E, F, G, and H) under contaminated conditions. Our results revealed that, consistent with our prior studies, human subjects were able to rank and differentiate surfaces according to slipperiness. Moreover, the surfaces evaluated in this study demonstrate characteristics that make them suitable replacements for the ASTM F2508 reference surfaces. Based on our findings, we recommend that ASTM F2508 be updated using surfaces E, F, and G and that surface G be considered a candidate to establish a slip resistance threshold for walking.
Desplazamiento altitudinal de las zonas productoras de cacao en el departamento Norte de Santander por efectos de las variaciones climáticas
Authors: Nuñez-Rodríguez José de Jesús 
Published: September 2021

El objetivo de la investigación fue evaluar los efectos de las variaciones climáticas en las características físicas de las almendras de cacao (Theobroma cacao L.) en 6 gradientes altitudinales del departamento Norte de Santander, Colombia. Se seleccionaron 12 fincas, de pequeños productores, localizadas entre los 0 msnm hasta los 1.200 msnm. Asimismo, se analizaron los registros de 36 años de temperaturas y precipitaciones medias obtenidos de una estación meteorológica del Instituto de Hidrología, Meteorología y Estudios Ambientales (IDEAM), ubicada a 50 msnm dentro del área de influencia de las zonas cacaoteras evaluadas. En cada unidad de análisis se caracterizaron muestras de 300 gramos de almendras secas, de la cosecha de marzo-junio 2019, a las cuales se les determinó el peso de 100 almendras y el porcentaje de cascarilla. Los datos fueron analizados a través de estimadores descriptivos, ANAVAR y la Prueba de Tukey. Los resultados evidenciaron incrementos significativos en las temperaturas de 0.0315 °C/año y variaciones en el peso de las almendras significativas, p ˂ 0.01, Fc= 33.4, infiriéndose la aparición de 2 franjas climáticas para la producción de cacao en el departamento, la primera ubicada entre los 0 a los 600 msnm con granos medianos y grandes y altos contenidos de cascarilla y; la segunda, situada sobre los 600 hasta los 1.200 msnm, con granos de tamaño grande y bajo porcentaje de cascarilla. En conclusión, se establece que las variaciones climáticas están generando efectos negativos en los principales municipios productores de cacao del departamento y, al mismo tiempo, abre nuevos espacios para el desarrollo del cultivo en los municipios con altitudes superiores a los 600 msnm.
Medial plantar nerve: normative parameters of an electroneuromyographic study in adults
Authors: Grishina D. A. , Suponeva N. A. 
Published: September 2021

Background. The study of the sensitive portion of the medial plantar nerve is relevant not only in the examination of patients with tibial nerve mononeuropathy or its branches, but also in the diagnosis of polyneuropathies.Objective: to analyze the normative parameters of the sensory potential recorded during the study of the medial plantar nerve by the orthodromic method in healthy adults.Materials and methods. 126 sensitive fibers of the medial plantar nerves were studied on the Dantec Keypoint G4 device (Denmark) in 63 healthy individuals (31 men and 32 women; age from 20 to 80 years). 3 groups were identified taking into account age: group 1 included healthy people aged 20 to 39 years (n = 23); group 2 consisted of people aged 40 to 60 years (n = 20); and 3 – older than 60 years (n = 20). The parameters of the sensory potential of the medial plantar nerve are analyzed.Results. The sensory potential in the study of the sensitive portion of the medial plantar nerve was registered in all 126 healthy subjects. Comparative statistical analysis did not demonstrate significant differences between groups 1–3 in the values of such parameters of the sensory potential as the latency of the onset, the duration of the negative phase and the rate of propagation of excitation. At the same time, in groups 2 and 3, the magnitude of the amplitude from peak to peak of the sensory potential was significantly lower compared to group 1, and averaged 8.92 and 7.86 MV, respectively.Conclusion. Knowledge of the regulatory parameters will allow expanding the use of electroneuromyography of the sensitive portion of the medial plantar nerve in clinical and research practice.
Effects and safety of high-frequency repetitive transcranial magnetic stimulation in trigeminal neuralgia
Authors: Poydasheva A. G. , Bakulin I. S. , Lagoda D. Yu. , Suponeva N.   A. , Piradov M.  A. 
Published: September 2021

Background. Trigeminal neuralgia is the most common cause of facial pain. Insufficient effectiveness and frequent side effects of pharmacological therapy, as well as the risk of complications of invasive neurosurgical manipulations, determine the relevance of the development of new treatment approaches, one of which is repetitive transcranial magnetic stimulation (rTMS).The aim of the study is to determine the effectiveness of high‑frequency rTMS of the primary motor cortex in terms of pain intensity and quality of life in patients with trigeminal neuralgia, as well as to assess the safety of the stimulation course.Materials and methods. This open‑label non‑randomized single arm study included 20 patients with classic trigeminal neuralgia according to the ICHD‑3 classification. All patients received 10 sessions of navigated high‑frequency rTMS of the primary motor cortex (hand area) of the hemisphere, contralateral to pain syndrome localization. The maximum and average pain intensity was assessed before and after 10 rTMS sessions according to a Numeric Pain Rating Scale (NPRS), as well as quality of life was measured according to the SF‑36 questionnaire, and the severity of affective disorders according was measured to the Beck Depression Inventory (BDI). Safety and tolerability of rTMS were assessed using self‑developed questionnaires for adverse events that occurred during stimulation and within 24 hours after the previous session.Results. A significant decrease in the maximum (p = 0.01) and average (p <0.01) pain intensity was shown after 10 sessions of rTMS. In 50 % of patients, the maximum pain intensity decreased by more than 30 % vs baseline. Significant changes were detected in the physical health measure of SF‑36 quality of life questionnaire, particularly, in the “bodily pain” domain, as well as in such aspects of the mental health measure as “vitality” and “social functioning”. The severity of affective disorders did not change significantly. A favorable profile of rTMS tolerability has been demonstrated.Conclusion. An open‑label study showed the possible effectiveness of 10 sessions of high‑frequency rTMS to reduceт the pain intensity in patients with trigeminal neuralgia. For the first time, the spectrum of adverse events both during stimulation and within a day after its completion was systematically analyzed.
Physics-Based Simulation of Spatiotemporal Patterns of Earthquakes in the Corinth Gulf, Greece, Fault System
Authors: Console Rodolfo , Carluccio Roberto , Murru Maura , Papadimitriou Eleftheria , Karakostas Vassilis 
Published: September 2021

ABSTRACT
A physics-based earthquake simulation algorithm for modeling the long-term spatiotemporal process of strong (M ≥ 6.0) earthquakes in Corinth Gulf area, Greece, is employed and its performance is explored. The underlying physical model includes the rate- and state-dependent frictional formulation, along with the slow tectonic loading and coseismic static stress transfer. The study area constitutes a rapidly extending rift about 100 km long, where the deformation is taken up by eight major fault segments aligned along its southern coastline, and which is associated with several strong (M ≥ 6.0) earthquakes in the last three centuries, since when the historical earthquake catalog is complete. The recurrence time of these earthquakes and their spatial relation are studied, and the simulator results reveal spatiotemporal properties of the regional seismicity such as pseudoperiodicity as well as multisegment ruptures of strong earthquakes. As the simulator algorithm allows the display of the stress pattern on all the single elements of the fault, we are focusing on the time evolution of the stress level before, during, and after these earthquakes occur. In this respect, the spatiotemporal variation of the stress and its heterogeneity appear to be correlated with the process of preparation of strong earthquakes in a quantitative way.
Efektivitas Learning Cycle 3E Berkonteks Socioscientific Issues terhadap Pemahaman Konsep dan Penjelasan Ilmiah Siswa Sekolah Dasar
Authors: Arini Dita Setya , Rahayu Sri , Kusairi Sentot 
Published: September 2021

<p><strong>Abstract:</strong> This study aims to determine the effectiveness of the 3E learning cycle model in the context of socioscientific issues on conceptual understanding and scientific explanations of grade V students on science content. This study used a quasy experimental approach with posttest only control group design. The subjects of this study were fifth grade students in two public schools in Kalipare sub-district, namely SDN A and SDN B. The research instruments consisted a conceptual test of 20 multiple choice questions (α Cronbach’s = 0,842) and 5 scientific explanation test with essay questions (α Cronbach’s = 0,882). The answers of scientific explanations are categorized using SOLO Taxonomy and tested by Cohen Kappa. Data analysis using ANOVA, Post Hoc further test and effect size. Product moment correlation test is used to see the correlation between understanding concepts and scientific explanations. The results of the study show that the 3E learning cycle model has socioscientific issues contexts that are effective in improving students' understanding of concepts and scientific explanations. Correlation analysis between understanding concepts and scientific explanations has a positive correlation.</p><strong>Abstrak: </strong>Penelitian ini bertujuan untuk mengetahui efektivitas model <em>learning cycle</em> 3E berkonteks <em>socioscientific issues</em> terhadap pemahaman konsep dan penjelasan ilmiah siswa kelas V pada muatan IPA. Penelitian ini menggunakan pendekatan <em>quasy eksperimental </em>dengan <em>posttest only control group design</em>. Subjek penelitian adalah siswa kelas V di dua sekolah negeri kecamatan Kalipare, yaitu SDN A dan SDN B. Instrumen penelitian terdiri dari tes pemahaman konsep 20 soal pilihan ganda dan 5 soal <em>essay</em> tes penjelasan ilmiah. Jawaban penjelasan ilmiah dikategorikan menggunakan Taksonomi SOLO dan diuji <em>Cohen Kappa</em>. Analisis data menggunakan uji ANOVA, uji lanjut <em>Post Hoc,</em> dan <em>effect size</em>. Uji <em>korelasi product moment</em> digunakan untuk melihat hubungan antara pemahaman konsep dan penjelasan ilmiah. Hasil penelitian menunjukkan bahwa model <em>learning cycle</em> 3E berkonteks <em>socioscientific issues</em> efektif untuk meningkatkan pemahaman konsep dan penjelasan ilmiah siswa. Analisis korelasi antara pemahaman konsep dan penjelasan ilmiah memiliki hubungan positif.
The Analysis of Proceeding Papers’ Coherence through Thematic Progression Manifestation
Authors: Ar Ruhimat Imroati Istibsyaroh , Basthomi Yazid , Wulyani Anik Nunuk 
Published: September 2021

<p><strong>Abstract:</strong> Twenty research papers published in international conference proceedings are analyzed in terms of its thematic progression manifestation to know the coherence built within the papers. The analysis obtained that among the three thematic progression manifest, zig-zag pattern is the most frequent pattern manifest by 388 patterns, followed by theme reiteration by 317 patterns and multiple rheme by only 8 patterns. This indicates that although the writers are lack of information regarding thematic progression, their unconscious manifestation of thematic progression allows the coherence built within the text, making the readers able to comprehend and understand the papers easily. </p><strong>Abstrak:</strong><em> </em>Sebanyak 20 artikel yang telah publikasi di prosiding konferensi internasional dianalisis berdasarkan manifestasi Pola Great Tema untuk mengetahui koherensi yang dikembangkan dalam artikel. Diketahui berdasarkan analisis tersebut, dari tiga Pola Gerak Tema yang dimanifestasi, pola <em>zig-zag</em> adalah yang banyak dengan 388 pola, diikuti dengan <em>theme reiteration </em>dengan 317 pola, dan pola <em>multiple-rheme </em>dengan 8 pola. Hasil ini mengindikasikan bahwa, walaupun penulis kurang mendapatkan informasi mengenai Pola Gerak Tema, namun mereka dapat menggunakan Pola Gerak Tema tersebut secara tidak sadar sehingga koherensi dalam artikel terbentuk, dan pembaca dapat mengerti isi artikel tersebut.
Proses Manajemen Peserta Didik di SMA Binaan Universitas
Authors: Firmansyah Tri , Mustiningsih Mustiningsih , Sunandar Asep 
Published: September 2021

<p><strong>Abstract:</strong> The writing of this article aims to analyze and describe of process student management of university’s senior high school. Method in this research is descriptive qualitative, the technique of collecting data through interview, observation, and documentation, and were data analysed by interactive model, trouhg reduction, display, and conclution. Subjects as data resource in this research were researcher, principal, and vice principal of student. Finding of this research indicates the student management process held by cooperation between school and university in auditing in every functions of student management.</p><strong>Abstrak:</strong> Penulisan artikel ini bermaksud untuk menganalisa dan mendeskripsikan proses manajemen peserta didik di SMA binaan universitas. Metode penelitian menggunakan kualitatif deskriptif, teknik pengumpulan data menggunakan observasi wawancara, observasi, dan dokumentasi, selanjutnya dianalisis dengan model interaktif melalui reduksi, penyampaian, dan konklusi. Subjek dalam penelitian ini adalah peneliti, kepala sekolah, wakil kepala kesiswaan, dan tenaga pendidik. Temuan dari penelitian ini menunjukan bahwa proses manajemen peserta didik dilaksanakan melibatkan kerjasama dengan universitas dalam pegauditan setiap fungsi dalam manajemen peserta didik.
Pengembangan Lembar Kerja Siswa Berbasis Problem Based Learning Berbantuan Papan Lipat untuk Mendukung Pemahaman Konsep Pecahan Siswa Kelas IV
Authors: Wahyuningati Nita Retno , Sa’dijah Cholis , Akbar Sa’dun 
Published: September 2021

<p><strong>Abstract:</strong> The purpose of the Research and Development is to <em>Lembar Kerja Siswa</em> a valid, practical, effective worksheet about fractions for elementary school students. Based on the assessment of the material experts, media experts, and users of both teachers and students can be obtained the following information. First, the development of PBL-based worksheet has fulfilled the valid criteria of 85%. Second, it fulfills practical criteria with an average overall response of teacher and student questionnaires of 87%. Third, it has fulfilled the effective criteria with an overall teacher and student response questionnaire of 87%. The results showed that the development of PBL-based worksheet based on folding boards met valid, practical, and effective criteria so that it was appropriate to be used as teaching material in learning.</p><strong>Abstrak:<em> </em></strong>Tujuan penelitian pengembangan untuk menghasilkan Lembar Kerja Siswa yang valid, praktis, dan efektif tentang pecahan untuk siswa sekolah dasar. Berdasarkan penilaian dari ahli materi, ahli media, dan pengguna baik guru dan siswa dapat diperoleh informasi sebagai berikut. <em>Pertama</em>, pengembangan Lembar Kerja Siswa berbasis <em>Problem Based Learning</em> telah memenuhi kriteria valid sebesar 85%. <em>Kedua</em>, memenuhi kriteria praktis dengan rata-rata keseluruhan angket respons guru dan siswa sebesar 87%. <em>Ketiga</em>, telah memenuhi kriteria efektif dengan rata-rata keseluruhan angket respons guru dan siswa sebesar 87%. Hasil penelitian menunjukkan bahwa pengembangan LKS berbasis <em>Problem Based Learning</em> berbantuan papan lipat telah memenuhi kriteria valid, praktis, dan efektif sehingga layak digunakan sebagai bahan ajar dalam pembelajaran.
Hepáticas (Marchantiophyta) do Parque Nacional Chapada das Mesas: novos registros para o Bioma Cerrado
Authors: Costa Filipe Bezerra , Silva Guilherme Sousa da , Santos-Silva Domingos Lucas dos , Gomes Gustavo Da Silva , Peralta Denilson Fernandes , Oliveira Hermeson Cassiano de 
Published: September 2021

<p>A presente pesquisa consiste em um estudo sobre as briófitas (<em>Marchantiophyta</em>) do Parque Nacional Chapada das Mesas (PNCM). O Parque situa-se na bacia do rio Tocantins, em seu médio curso, no Sul do estado do Maranhão e possui significativa biodiversidade de espécies da flora e fauna do Cerrado. Foram identificadas sete famílias, 16 gêneros e 27 espécies de hepáticas para o PNCM. O estudo registra uma nova ocorrência para a região Nordeste, 10 para o estado do Maranhão e três para o Cerrado. São fornecidos dados sobre as formas de vida, substratos colonizados e distribuição geográfica das espécies. Os resultados contribuem para o conhecimento das hepáticas do Maranhão, Brasil e região Neotropical. </p>
Consumo do álcool em debate: uma proposta de ensino voltada a jovens da Educação Profissional e Tecnológica
Authors: Gurgel Ítala Kelley Melo Napolião , Amaral José Araújo 
Published: September 2021

<p class="Normal1">Este artigo objetiva apresentar uma proposta de ensino caracterizada como intervenção pedagógica e pautada pela temática do consumo de álcool. A proposta é direcionada ao público discente da Educação Profissional e Tecnológica e pode ser desenvolvida por docentes da área de Ciências Biológicas ou como atividade integrada com outras disciplinas, tais como Língua Portuguesa, História, Sociologia ou Qualidade de Vida no Trabalho. Metodologicamente, nosso trabalho parte de uma pesquisa exploratória de caráter bibliográfico para a construção de uma proposta de ensino do tipo intervenção pedagógica, conforme preconizado por Damiani <em>et al</em>. (2013). O desenho da proposta pressupõe que a temática do consumo de álcool deve ir além da abordagem médica, pautando-se pela integração de conhecimentos de áreas distintas, e suas principais bases são mostradas no referencial teórico. Propomos uma intervenção que se concretize em seis semanas, com duas horas-aula semanais, e tome por base a combinação da exposição dialogada docente com ações discentes que envolvam a escrita, a oralidade, a pesquisa e a reflexão crítica sobre os conteúdos propostos. Acreditamos que a aplicação dessa proposta oferecerá experiências reflexivas e questionadoras, bem como contribuirá para a formação cidadã e o aumento da criticidade e da autonomia discentes, almejadas como princípios da Educação Profissional e Tecnológica. </p>