bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward Personalized Treatment for Patients with Low von Willebrand Factor and Quantitative von Willebrand Disease
Authors: O'Donnell James S. 
Published: February 2021

AbstractThe biological mechanisms involved in the pathogenesis of type 2 and type 3 von Willebrand disease (VWD) have been studied extensively. In contrast, although accounting for the majority of VWD cases, the pathobiology underlying partial quantitative VWD has remained somewhat elusive. However, important insights have been attained following several recent cohort studies that have investigated mechanisms in patients with type 1 VWD and low von Willebrand factor (VWF), respectively. These studies have demonstrated that reduced plasma VWF levels may result from either (1) decreased VWF biosynthesis and/or secretion in endothelial cells and (2) pathological increased VWF clearance. In addition, it has become clear that some patients with only mild to moderate reductions in plasma VWF levels in the 30 to 50 IU/dL range may have significant bleeding phenotypes. Importantly in these low VWF patients, bleeding risk fails to correlate with plasma VWF levels and inheritance is typically independent of the VWF gene. Although plasma VWF levels may increase to > 50 IU/dL with progressive aging or pregnancy in these subjects, emerging data suggest that this apparent normalization in VWF levels does not necessarily equate to a complete correction in bleeding phenotype in patients with partial quantitative VWD. In this review, these recent advances in our understanding of quantitative VWD pathogenesis are discussed. Furthermore, the translational implications of these emerging findings are considered, particularly with respect to designing personalized treatment plans for VWD patients undergoing elective procedures.
Genomic Analysis for the Detection of Bleeding and Thrombotic Disorders
Authors: Gomez Keith 
Published: February 2021

AbstractThe development of high-throughput sequencing technologies has ushered in a new era of genomic testing in clinical medicine. This has greatly enhanced our diagnostic repertoire for hemostatic diseases particularly for milder or rarer bleeding disorders. New genetic causes for heritable platelet disorders have been discovered along with the recognition of clinical manifestations outside hemostasis, such as the association of leukemia with RUNX1 variation. Genome-wide association studies in heritable thrombophilia have demonstrated that some of the genetic variants that are commonly included in thrombophilia testing are of no clinical relevance, while uncovering new variants that should potentially be included. The implementation of new technology has necessitated far-reaching changes in clinical practice to deal with incidental findings, variants of uncertain significance, and genetic disease modifiers. Mild bleeding disorders that were previously considered to have a monogenic basis now appear to have an oligogenic etiology. To harness these advances in knowledge large databases have been developed to capture the new genomic information with phenotypic features on a population-wide scale. The use of this so-called “big data” requires new bioinformatics tools with the promise of delivering precision medicine in the foreseeable future. This review discusses the use of these technologies in clinical practice, the benefits of genomic testing, and some of the challenges associated with implementation.
Direct Oral Anticoagulants Plasma Levels Measurement: Clinical Usefulness from Trials and Real-World Data
Authors: Renon Francesca , Rago Anna , Liccardo Biagio , D'Andrea Antonello , Riegler Lucia , Golino Paolo , Nigro Gerardo , Russo Vincenzo 
Published: February 2021

AbstractMeasurement of direct oral anticoagulants (DOACs) activity is not routinely necessary. Indeed, evaluation of DOACs plasmatic concentration is discouraged for the majority of patients, due to the lack of outcome data supporting this approach. Nevertheless, DOAC measurements may be useful in emergency situations such as serious bleeding events, need for urgent invasive procedures, and acute ischemic stroke or in managing anticoagulation in “special populations” not adequately studied in clinical trials, for example the very elderly or those at the extremes of body weight. The aim of this review is to describe and summarize the methods for DOACs activity evaluation and the settings in which their plasma level measurement may be indicated, analyzing indications from scientific societies and evidence from clinical trials, as well as real world data on the usefulness of DOACs plasma levels “monitoring.”
Type 2B von Willebrand Disease in Pregnancy: A Systematic Literature Review
Authors: Makhamreh Mona M. , Russo Melissa L. , Karl Taylor , Delgado Natalie , Lackritz Katherine , Skupski Daniel W. , Al-Kouatly Huda B. 
Published: February 2021

AbstractOur objective was to review the maternal characteristics and obstetric complications in women with type 2B von Willebrand disease (VWD). A systematic literature search was conducted using PubMed, Scopus, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov. We included all publications that addressed type 2B VWD in pregnancy. Our primary and secondary outcomes were incidence of postpartum hemorrhage (PPH) and incidence of thrombocytopenia in pregnancy. Two reviewers independently identified eligible studies and abstracted data including maternal characteristics, hematologic characteristics, treatment, and delivery outcomes. Twenty studies met inclusion criteria. There were 27 women (32 pregnancies) with type 2B VWD. Primary PPH was reported in 9/20 women (45%) and secondary PPH was reported in 6/13 women (46%). Thrombocytopenia in pregnancy was present in 27/28 women (96%); 23/27 women (85%) had platelet count <100 × 109/L, mean 33.7 ± 22.7 × 109/L. Factor concentrate treatment was administered before delivery (n = 16) and postpartum (n = 18), some women received both. Seventeen deliveries required blood products postpartum with 13/17 (76%) platelet transfusions and 6/17 (35%) red blood cell transfusions. No maternal mortality was reported. Women with type 2B VWD have significant morbidity in pregnancy related to high incidence of severe thrombocytopenia and primary and secondary PPH.
Diversifying relationships: Russian policy toward GCC
Authors: Issaev Leonid , Kozhanov Nikolay 
Published: February 2021

AbstractThe interaction between Russia and Gulf countries represents the story of ups and downs, severe conflicts and sharp warmings that can largely be explained by the permanently changing role and place of each of these players at the global and Middle Eastern political arenas. After Russia's “return” to the Middle East in 2012–2015, Moscow's foreign policy towards the Gulf can be explained in terms of a bargaining strategy. On the one hand, Russia is trying to underline its importance and relevance to the GCC by putting forward diplomatic and political initiatives. The Kremlin uses its direct or indirect presence in the key regional conflicts such as the Syrian, Libyan and Yemeni civil wars as well as the Israeli-Palestinian conflict and Iran’s nuclear issue. On the other hand, Russia is interested in building up stronger economic cooperation with the GCC, drawing bigger volumes of investments from the Gulf to Russia’s broken economy, as well as coordinating efforts with Saudi Arabia in the global oil market. While, in the near future, the qualitative evolution of Russia’s relations with the GCC is hardly possible, there are still options for their deepening within the current level of interaction between Moscow and the Gulf.
Questions in algebra and mathematical logic. Scientific heritage of S. I. Adian
Authors: Atabekyan V. S. , Beklemishev L. D. , Guba V. S. , Lysenok I. G. , Razborov A. A. , Semenov A. L. 
Published: February 2021

Abstract
This is a survey of results on the Burnside problem and properties of Burnside groups, the finite basis problem for group identities, periodic products of groups and Malcev’s problem, construction of groups with special properties (Tarski monsters), constructive bounds in the Burnside- Magnus problem, and algorithmic problems: the problem of recognition of group properties, the word problem for semigroups with one relation, and semi-Thue systems. The focus is on the most important results obtained in papers of Adian and his students.
Bibliography: 81 titles.
Physical activity and its association with cognitive function in middle‐ and older‐aged Chinese: Evidence from China Health and Retirement Longitudinal Study, 2015
Authors: Zhou Xiuxiu , Liao Shiming , Qi Ling , Wang Ruoxi 
Published: February 2021

ABSTRACTBackgroundDespite the known benefits of physical activity (PA) on cognitive function, the specific dimensions of PA that are associated with cognitive function require further research in China. We aimed to explore the patterns of PA and elucidate the association between cognitive function and different levels of PA in middle aged and elderly Chinese individuals.MethodsA total of 8,023 participants aged ≥45 years were selected from the China Health and Retirement Longitudinal Study. The PA intensity was categorized as: vigorous (VPA), moderate (MPA), and light (LPA). The associations of frequency and duration of PA at different intensities with cognitive function were examined using the multivariable linear model, including all respondents and urban‐rural subgroups.ResultsCompared with those who had no VPA, those who spent 6–7 days/week (β = −0.59, 95% CI: −1.10, −0.09) or more than 240 min/each time on VPA had poorer cognitive function among rural respondents, whereas cognitive function was only associated with the duration in urban respondents. Compared with those who had no MPA, the rural respondents who spent 1–5 days/week (β = 0.66, 95% CI: 0.12, 1.20) or 6–7days/week, or spent < 2 hours each time had better cognitive function. For LPA, frequency and duration were both positively associated with cognitive function, and were observed in both rural and urban sub‐groups.ConclusionsThe association between cognitive function and PA depended largely on the intensity and area. Cultural context and geographical differences should be considered when designing intervention policies.

Highlights
The prevalence of PA increased as the intensity decreased and was higher in rural respondents than in urban respondents.
Cognitive function was related to the intensity, frequency, and duration of PA. However, the magnitude and direction of the association depended mainly on the intensity and geographical area.
VPA was negatively correlated with cognitive function, and the association was significant only in rural respondents. However, MPA and LPA were positively correlated with cognitive function, while the association between LPA and cognitive function was significant in both rural and urban respondents.
Optimal control and optimization algorithm for a class of stochastic dynamic systems in intelligent control
Authors: Xiao Xiaonan 
Published: February 2021

Abstract
As we all know, big data and intelligent computing have been widely used in information science, life science, computer science and intelligent control, intelligent robots, vehicle networking, space technology, marine development and other fields, especially in the future life science and medical field. This paper is based on a new digital optimal decision-making idea of intelligent signal processing and control. On the basis of extending non-digital signal processing and information prediction to signal processing and information prediction in the digital generalized information measurement space, and making full use of optimization algorithms such as digital filtering and frequency spectrum analysis, this article discusses in depth the intelligent optimal control of a class of non-stationary random processes in artificial intelligence, biomedicine, radio communication, automatic control and other scientific and technological fields. It provides a new theory, a new approach and an effective and reliable new method for the mathematical modeling and optimal control of such processes, and has broad application prospects and value.
Research on cloud computing in the key technologies of railway intelligent operation and maintenance sharing platform
Authors: Yu Shu-Dan 
Published: February 2021

Abstract
Cloud data center has become a trend and mainstream, and the first phase of the main data center of National Railway Group has been completed, and the main data center also adopts cloud computing technology. Compared with traditional data centers, cloud data centers bring great convenience of unified and flexible resource scheduling to railroads, but also bring many new security risks. Therefore, the study of security architecture and key technologies for cloud data centers becomes an important requirement for securing railroad cloud data centers. While cloud computing brings convenience to railroads, it also brings new security risks. By studying the information security model, we construct a cloud security architecture that meets the actual situation of railroads. In terms of responsibility, according to the level protection responsibility sharing model should be divided into cloud-based security protection and cloud platform foundation protection; in terms of construction, according to the sliding scale model, it should overlap and evolve, and gradually complete the security construction in several stages of infrastructure security, deep defense, active defense and threat intelligence.
Application of identity resolution and blockchain technology in the whole industrial chain management of electrical equipment
Authors: Cui Jianye , Wang Huanjuan , Xue Wenhao , Wang Bin 
Published: February 2021

Abstract
As the proportion of electric energy in the world energy consumption increases year by year, the demand and usage of electrical equipment also increase. For a lot of electrical equipment management, the traditional management method is unable to get through data barriers that exist in the industrial chain; the information interaction between each link is more and more untimely, leading to a great increase of each link’s error rate. Not only reduces the safety of electrical equipment, but affects the response efficiency of other links when one link sends a request, lowers the quality of service. To solve this problem, this paper proposes the method of integrating the identity resolution system with blockchain technology to standardize the management of the whole industrial chain of electrical equipment. The data barriers between links are broken through the identity resolution system, and the blockchain technology is used to speed up the response of each link, and the key information is stored on the blockchain. This method carries out comprehensive management on the whole life cycle chain, conducts better standardized management on the field of electrical equipment in terms of intelligent trading, intelligent operation and maintenance, etc., and puts forward efficient management mode for the management of electrical equipment.
Network consumption demand analysis and structure optimization based on big data
Authors: Zhao Juanxia , Zhu Chunhong , Huang Yanmin 
Published: February 2021

Abstract
By studying the role and architecture of big data analysis, it is clear that it has a huge supporting role in analyzing customer behavior trajectory, discovering customer consumption habits and preferences, improving online consumption experience and promoting business decision-making. The big data analysis combined with scenario analysis can avoid the misreading of data analysis; strengthen the prediction ability of big data analysis, so as to create a truly satisfying customer experience. Based on the analysis and structure optimization of big data network consumption demand, the whole process network consumption experience theoretical model includes the experience demand model and experience behavior model. In order to deal with a large number of various types of data effectively, enterprises need to master the technology and ability of big data analysis. For online consumption platform enterprises, the most important consideration in the process of delivering customer experience is the customer group and customer needs and motivation, as well as customer perception of product and service experience process.
Analysis of renewable energy implementation in remote areas of Indonesia: study review
Authors: Fikriyyah A K , Boedoyo M S 
Published: February 2021

Abstract
Indonesia is the largest archipelago with 17,503 islands where 6000 populated islands and most of the islands are remote areas. This condition causes limited access to energy supplies such as electricity and fuel. Meanwhile, Indonesia has a variety of natural resources including renewable energy sources that have not been applied optimally. It is expected that the utilization of local renewable energy sources can guarantee the availability of electricity in remote areas so that it can support national development and security. To optimize renewable energy in remote areas, the government made Minister of Energy and Mineral Resources Regulation 38/2016 concerning the acceleration of electrification in undeveloped, remote, bordered, and small-populated rural areas through the implementation of small scale electricity supply businesses. To analyses the regulation and other supports, the SWOT method is used to know the impact of the regulation in the remote area. Coordination is needed between the Central Government and the Regional Governments. Also, control and evaluation of existing policies are required so that people in remote areas can get access to electricity optimally.
Feasibility analysis of rooftop solar photovoltaic for non-academic building in an educational institution in Malaysia
Authors: Zublie M F M , Hasanuzzaman M , Rahim N A 
Published: February 2021

Abstract
An educational institution is one of the sectors that consume a high amount of energy. An identify the energy consumption gives information to forecast the energy saving. The research aims to utilize rooftop solar photovoltaic (PV) at non-academic buildings in Malaysia’s educational institution. A detailed energy audit has been conducted at Politeknik Sultan Azlan Shah (PSAS) involving three non-academic buildings to identify the buildings’ energy usage. The three different building involved is the Islamic Centre (Mosque), Sports Centre, and Multipurpose Hall. The energy audit analysis is divided into four end-load groups comprising lighting, fans, air conditioning, and other equipment to identify each type of load’s energy consumption. Which equipment consumes the highest amount of energy in non-academic buildings in PSAS is determine. The results show that the highest energy consumption at the Islamic Centre and Multipurpose Hall is an air conditioner for a while Sports Centre is lighting equipment. Annual power generation and energy bill savings are calculated based on rooftop solar PV installation for self-consumption. From the feasibility analysis, the forecast of energy-saving for at-least 5% per year has been estimated. It significantly reduces the amount of carbon emission release to the environment.
Analysis of Flow Patterns in 55 Kilometers of Gas Transmission Pipelines due to Changes in Gas Supply Flow Rate
Authors: Ibrahim M H , Saputra A H 
Published: February 2021

Abstract
Pressure drop will cause a decrease in the temperature of natural gas in the pipe. This causes a two-phase flow to form along the pipe. The prediction of the two-phase gas-liquid flow pattern is needed in the oil and gas industry. The changes in gas supply will affect the flow pattern in the pipeline. The flow pattern in the pipe will be analyzed by Unisim software. The flow pattern result shows that there are instabilities of flow patterns along the pipe due to changing topographic conditions. When the pipe elevation drops to zero, as in kilometers 40-55, the flow pattern formed is constantly stratified flow. The results of stratified flow patterns indicate that the flow patterns do not cause sudden changes in liquid flow rate on the Receiving Facility (RF) equipment.
The Correlation between Enclosure and Customer’s Response
Authors: Fayadiva  , Gamal A 
Published: February 2021

Abstract
There is a change in store design that is widely used by brands to sell their products. Brands that use temporary store is no longer integrating any boundaries to separate the store from the environment around them. The existence of boundaries relates to the spatial quality of the store, which ultimately has a relation to the response of customers. The new trend of retail shows that enclosure is no longer needed to accommodate shopping experience. Unfortunately, there is still limited literature that studies the enclosure of the store as a spatial quality in a store environment. The purpose of this research is to examine the relationship between the enclosure of a store environment and the customer’s shopping experience. This paper also extends the research related to the store’s spatial quality and its relation to the customers. A literature review was conducted to further investigate the relationship between enclosure as the store’s spatial quality, product engagement, and customer responses. This study features three store simulation videos with three different types of enclosure (4 walls, 2 walls, 0 wall) and two sets of questionnaires to study the customer’s behavior. We interviewed 163 respondents from the age range of 19-35 in this study. The results indicate that the store with no enclosure encourages the customer to stay longer compared to the store with an enclosure. These findings can later be used as consideration for retail designers to develop their stores.
Private sector involvement in public space management and its varying degree of publicness
Authors: Piyaputri M , Gamal A 
Published: February 2021

Abstract
This paper aims to get a better understanding on the subject of private sector involvement in the management of public space and the degree of publicness of the space. While public space is one of urban’s essential infrastructure, private sector involvement in public spaces is said to have an effect to the lowering of the spaces’ degree of publicness. With private sectors being involved, certain groups of the public lost their rights to access these public spaces as private sectors often take advantages of the public’s rights for their own financial benefits. This study discusses the importance of a public space in a democratic society and the creation of new types of public spaces with varying degrees of publicness along with the emergence of private sector involvement. This paper will also discuss the dimensions of a space’s degree of publicness and previously made indices to evaluate public spaces in terms of their publicness.