bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone Erosions Detected by Ultrasound Are Prognostic for Clinical Arthritis Development in Patients With ACPA and Musculoskeletal Pain
Authors: Ziegelasch Michael , Eloff Emma , Hammer Hilde B. , Cedergren Jan , Martinsson Klara , Reckner Åsa , Skogh Thomas , Magnusson Mattias , Kastbom Alf 
Published: March 2021

Anti-citrullinated protein antibodies (ACPA) often precede onset of rheumatoid arthritis (RA) by years, and there is an urgent clinical need for predictors of arthritis development among such at-risk patients. This study assesses the prognostic value of ultrasound for arthritis development among ACPA-positive patients with musculoskeletal pain. We prospectively followed 82 ACPA-positive patients without clinical signs of arthritis at baseline. Ultrasound at baseline assessed synovial hypertrophy, inflammatory activity by power Doppler, and erosions in small joints of hands and feet. We applied Cox regression analyses to examine associations with clinical arthritis development during follow-up (median, 69 months; range, 24–90 months). We also compared the ultrasound findings among the patients to a control group of 100 blood donors without musculoskeletal pain. Clinical arthritis developed in 39/82 patients (48%) after a median of 6 months (range, 1–71 months). One or more ultrasound erosions occurred in 13/82 patients (16%), with none in control subjects (p &lt; 0.001). Clinical arthritis development was more common among patients with baseline ultrasound erosions than those without (77 vs. 42%, p = 0.032), and remained significant in a multivariable Cox regression analysis that included previously described prognostic factors (HR 3.9, 95% CI 1.6–9.4, p = 0.003). Ultrasound-detected tenosynovitis was more frequent among the patients and associated with clinical arthritis development in a univariable analysis (HR 2.5, 95% CI 1.1–5.7, p = 0.031), but did not remain statistically significant in multivariable analysis. Thus, bone erosions detected by ultrasound are independent predictors of clinical arthritis development in an ACPA-positive at-risk population.Trial Registration: Regional Ethics Committee in Linköping, Sweden, Dnr M220-09. Registered 16 December 2009, https://etikprovningsmyndigheten.se/.
Gluten-Free Foods Cooked in Shared Fryers With Wheat: A Pilot Study Assessing Gluten Cross Contact
Authors: Thompson Tricia , Lyons Trisha Bury , Keller Amy , Jaffe Nancee , Emerson-Mason Luke 
Published: March 2021

Introduction: Consumers with celiac disease are discouraged from eating fried foods cooked in shared fryers with wheat-containing foods at restaurants based on presumed gluten exposure. The purpose of the present study is to assess gluten levels of fries free of gluten-containing ingredients cooked in shared fryers with wheat.Methods: 20 orders of fries were purchased from 10 different restaurants. Restaurants confirmed that fries and oil were free of gluten-containing ingredients. All restaurants confirmed that their fryers were used to cook wheat-containing foods. Fries were sent to Bia Diagnostics and tested in 1-gram duplicates using the R7001 sandwich R5 ELISA and the R7021 competitive R5 ELISA. A microwave control also was run.Results: The sandwich ELISA found gluten in 9/20 fry orders (7 to &gt; 80 ppm). The competitive ELISA found gluten in 3/20 fry orders (14 to &gt; 270 ppm). In the microwave control (60-ppm gluten mixture of wheat flour and canola oil), the unheated mixture tested at a mean level of 64 ppm gluten using the sandwich ELISA and 137 ppm gluten using the competitive ELISA. The mixture heated to 190°C tested at a mean level of 55 ppm gluten using the sandwich ELISA and &lt; 10 ppm and 16 ppm gluten using the competitive ELISA.Discussion: Based on test results, 25% of fry orders would not be considered gluten-free.Summary: Gluten cross contact may occur when gluten-free foods are cooked in shared fryers with wheat. ELISAs may underperform when analyzing for gluten that has been heated.
The Efficacy and Safety of Programmed Death-1 and Programmed Death Ligand 1 Inhibitors for the Treatment of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
Authors: He Shukang , Jiang Weichao , Fan Kai , Wang Xiaobei 
Published: March 2021

BackgroundHepatocellular carcinoma (HCC) is often diagnosed at an advanced stage where only systemic treatment can be offered. The emergence of immune checkpoint inhibitors (ICIs) provides hope for the treatment of HCC. In this study, we performed a meta-analysis to provide evidence for the efficacy and safety of ICIs in the treatment of HCC.MethodsThe following databases and websites were searched: Embase, PubMed, Cochrane Library and ClinicalTrials.gov. The primary endpoints were response rate (RR), disease control rate (DCR), progression-free survival (PFS) and overall survival (OS).ResultsFinally, twelve studies were included in this meta-analysis. When the corresponding outcome indicators and their 95% confidence intervals (CIs) were pooled directly, the overall RR, DCR, PFS and OS were 0.17 (0.15-0.19, I2 = 56.2%, P=0.009), 0.58 (0.55-0.61, I2 = 75.9%, P&lt;0.001), 3.27 months (2.99-3.55, I2 = 73.0%, P=0.001), 11.73 months (10.79-12.67, I2 = 90.3%, P&lt;0.001). Compared to the control group, treatment with ICIs significantly improved RR, PFS and OS, the OR and HRs were 3.11 (2.17-4.44, P&lt;0.001), 0.852 (0.745-0.974, P=0.019) and 0.790 (0.685-0.911, P=0.001), respectively. However, no significant improvement in DCR was found in ICIs treatment in this meta-analysis.ConclusionHCC patients would benefit from ICIs treatment, however, more studies are needed in the future to provide more useful evidence for the treatment of HCC by programmed death-1 (PD-1) or programmed death ligand 1 (PD-L1) inhibitors.
The Acute and Late Toxicities of MRI-Guided External Beam Partial Breast Irradiation Delivered Using a Once-Per-Day Regimen
Authors: Lee Hye In , Kim Kyubo , Kim Jin Ho , Chang Ji Hyun , Shin Kyung Hwan 
Published: March 2021

Background and PurposeThe use of external beam accelerated partial breast irradiation (APBI) using a twice-per-day regimen has raised concerns about increase rates of late toxicities. We compared toxicity outcomes of external beam APBI using a once-per-day regimen and accelerated hypofractionated whole breast irradiation (AWBI) in patients with early-stage breast cancer.Materials and MethodsThis was a single-institution, retrospective cohort study. Patients aged ≥50 years with pTisN0 or pT1N0 breast cancer who underwent breast-conserving surgery and adjuvant radiotherapy were included. APBI was delivered at 38.5 Gy in 10 fractions once daily using magnetic resonance imaging (MRI)-guided radiotherapy only to patients who were strictly “suitable”, according to the ASTRO-APBI guidelines. AWBI was delivered at 40.5–43.2 Gy in 15 or 16 fractions with or without a boost.ResultsBetween October 2015 and December 2018, 173 and 300 patients underwent APBI and AWBI, respectively. At a median follow-up of 34.9 months (range 7.1 to 55.4 months), the 3-year recurrence-free survival rates of the APBI and AWBI groups were both 99.2% (p=0.63). Acute toxicities were less frequent in the APBI than AWBI group (grade 1: 95 [54.9%] vs. 233 [77.7%] patients; grade 2: 7 [4.0%] vs. 44 [14.7%] patients; no grade ≥3 toxicities were observed in either group, p&lt;0.001). Late toxicities were less common in the APBI than AWBI group (grade 1: 112 [64.7%] vs. 197 [65.7%] patients; grade 2: 9 [5.2%] vs. 64 [21.3%] patients; grade 3: 0 vs. 5 [1.7%] patients, p&lt;0.001). Multivariate analysis showed that APBI was significantly associated with fewer late toxicities of grade ≥2 compared with AWBI (odds ratio 4.17, p=0.006).ConclusionOnce-per-day APBI afforded excellent locoregional control and fewer toxicities compared with AWBI. This scheme could be an attractive alternative to AWBI in patients who meet the ASTRO-APBI guidelines.
Meaning in Life Mediates Between Emotional Deregulation and Eating Disorders Psychopathology: A Research From the Meaning-Making Model of Eating Disorders
Authors: Marco Jose H. , Cañabate Montserrat , Martinez Cristina , Baños Rosa M. , Guillen Verónica , Perez Sandra 
Published: March 2021

Emotional dysregulation, age, gender, and obesity are transdiagnostic risk factors for the development and maintenance of eating disorders (EDs). Previous studies found that patients with ED had less meaning in life than the non-clinical population, and that meaning in life acted as a buffer in the course of ED; however, to the data, there are no studies about the mediator role of meaning in life in association between the emotional dysregulation and the ED psychopathology.Objective: To analyze the mediating role of meaning in life in the relationship between emotional dysregulation and the ED psychopathology in three samples with diverse risk factors for ED.Method: Sample 1, n = 153 undergraduate young women; sample 2, n = 122 participants with obesity; and sample 3, n = 292 participants with ED. Multiple mediation analysis was performed.Results: Sample 1: meaning in life showed a mediation effect between emotional dysregulation and the ED psychopathology (direct effect β = 0.390, p &lt; 0.05) (indirect effect β = 0.227, p &lt; 0.05), body satisfaction (direct effect β = −0.017, p &lt; 0.05) (indirect effect β = −0.013, p &lt; 0.01), and depression symptoms (direct effect β = 1.112, p &lt; 0.001) (indirect effect β = 0.414, p &lt; 0.001); sample 2: meaning in life showed a mediation effect between emotional dysregulation and binge eating and purging behaviors (direct effect β = 0.194, p &lt; 0.01) (indirect effect β = 0.054, p &lt; 0.05) and depression symptoms (direct effect β = 0.357, p &lt; 0.001) (indirect effect β = 0.063, p &lt; 0.05); sample 3: meaning in life showed a mediation effect between emotional dysregulation and the ED psychopathology (direct effect β = 0.884, p &lt; 0.001) (indirect effect β = 0.252, p &lt; 0.007), body satisfaction (direct effect β = −0.033, p &lt; 0.05) (indirect effect β = −0.021, p &lt; 0.001), borderline symptoms (direct effect β = 0.040, p &lt; 0.001) (indirect effect β = 0.025, p &lt; 0.001), and hopelessness (direct effect β = 0.211, p &lt; 0.001) (indirect effect β = 0.087, p &lt; 0.001).Conclusions: These studies suggest the importance of considering meaning in life as a variable in the onset and maintenance of ED.
Prevalence of Shift Work Disorder: A Systematic Review and Meta-Analysis
Authors: Pallesen Ståle , Bjorvatn Bjørn , Waage Siri , Harris Anette , Sagoe Dominic 
Published: March 2021

Objectives: No systematic review or meta-analysis concerning the prevalence of shift work disorder (SWD) has been conducted so far. The aim was thus to review prevalence studies of SWD, to calculate an overall prevalence by a random effects meta-analysis approach and investigate correlates of SWD prevalence using a random-effects meta-regression.Methods: Systematic searches were conducted in ISI Web of Science, PsycNET, PubMed, and Google Scholar using the search terms “shift work disorder” and “shift work sleep disorder.” No restrictions in terms of time frame were used. Included studies had to present original data on the prevalence of SWD in an occupational sample published in English. A total of 349 unique hits were made. In all, 29 studies were finally included from which two authors independently extracted data using predefined data fields. The meta-regression included four predictors (diagnostic criteria, study country, type of workers, and sample size).Results: The overall prevalence of SWD was 26.5% (95% confidence interval = 21.0–32.8). Cochran Q was 1,845.4 (df = 28, p &lt; 0.001), and the I2 was 98.5%, indicating very high heterogeneity across the observed prevalence estimates. Diagnostic criteria (International Classification of Sleep Disorders-2 = 0, International Classification of Sleep Disorders-3 = 1) and sample size were inversely related to SWD prevalence.Conclusions: The prevalence of SWD was high across the included studies. The between-study disparity was large and was partly explained by diagnostic criteria and sample size. In order to facilitate comparative research on SWD, there is a need for validation and standardization of assessment methodology as well as agreement in terms of sample restrictions.
Implementasi Point Of Sales Menggunakan Metode EOQ Berbasis Web
Authors: Fajar Ahmad 
Published: March 2021

— Point of sales (POS) adalah sebuah sistem yang digunakan untuk proses transaksi penjualan, Stok Barang dan mengolah data. Sistem ini dibangun berbasis web dan Bahasa pemrograman PHP dan MYSQL dengan metode manajemen stok barang yaitu Economic Order Quantity (EOQ) . Metode EOQ adalah metode yang digunakan menentukan pemesanan barang atau pembelian barang yang harus dilakukan dan berapa banyak jumlah barang yang harus dipesan. Dalam metode konvesional untuk menentukan pemesanan dalam jumlah 1.200 unit dalam satu tahun, biaya pemesanan Rp 210.000, harga perunit sebesar Rp 897.955 dan penyimpanan 5%. Pelaku usaha menggunakan metode konvensional dengan pembelian sebanyak 200 unit dengan dengan banyaknya pemesanan 6 kali dan persediaan pengaman sebesar 50. Dalam penelitian ini penulis menggunakan perhitungan metode EOQ untuk menentukan jumlah barang 1200 per tahun. maka akan dihasilkan pemesanan barang 106 dengan frekuensi 11 kali safety stock 15 dan ROP 24. Simpulan dari penelitian ini adalah untuk membuat perhitungan stok barang menggunakan metode EOQ pada pembelian barang lebih efisien dibandingkan dengan metode manual/konvensional.
Epistemology of Basic Concepts of Spiritual and Physical Thaharah: Analysis of The Benefits of Ablution Spiritually and Physically
Authors: . Meirison . , Insani Fadhilah Insani . , Andini Zahara 
Published: March 2021

This article aims to explain the purpose of purification in various forms. Purification outwardly and inwardly will be obtained when following the rules given by the Qur'an and Hadith. Purification (thaharah) is one of the legal conditions in performing Salat. When we start performing an act of worship such as Salat, many of us are not right or wrong when taking ablution or sometimes after removing many unclean impurities. I did a literature study with a descriptive analysis approach and found that three ways can be pure: bathing, ablution, and tayammum. The tools used for bathing and ablution are water and for tayammum using soil (dust). As we know, Tayammum can only be done when there is no water and in a state of pain. Purification also removes not only the contaminated feces but also the inner. In purifying, using absolute water or using soil (dust) must meet certain conditions. By doing purification according to the provisions of Rasulullah, then we will get external and internal purity.
Keywords: Epidemiology, Concept, Spiritual, Physical, Thaharah
Praktik Akad Istishna' Paralel dalam Jual Beli Rumah di PT. Berkah Rangga Sakti Kecamatan
Authors: Buhari Taufiq 
Published: March 2021

Today the need for a place to live is a factor in the community to meet their daily needs, even though they do not have enough money, people are competing to own a house, so that many people get a place to live by paying in installments with various systems in their respective places of residence. Application of a parallel istishna 'contract in buying and selling houses in a company PT. Berkah Rangga Sakti, which is engaged in selling houses, has met the requirements and principles that apply in the shari'ah economy. But in the financing of PT. Berkah Rangga Sakti did not use a Syari'ah Bank but a conventional bank due to the difficulty of accessing the Syari'ah Bank, which provides home financing in the Bangkalan area.
Metode Kisah dalam Meningkatkan Motivasi Belajar dan Kemampuan Bercerita pada Pembelajaran Sejarah Kebudayaan Islam di Madrasah Ibtidaiyah
Authors: Azizeh Siti Nur 
Published: March 2021

Pembelajaran Sejarah Kebudayaan Islam merupakan pembelajaran yang cenderung monoton sehingga peserta didik mudah merasa bosan. Penyebabnya karena dalam menyampaikan materi umumnya dengan metode ceramah tanpa adanya media pembelajaran yang digunakan. Hal ini membuat minat dan motivasi siswa menurun, akibatnya materi yang dijelaskan oleh guru tidak dapat diterima dan dipahami secara mudah. Berdampak pada rendahnya kemampuan bercerita pada peserta didik. Oleh sebab itu, guru dituntut memberikan inovasi dalam menciptakan pembelajaran yang menyenangkan, salah satunya dengan mengubah metode dalam menyampaikan materi pelajaran. Penerapan metode kisah dianggap tepat dan relevan dengan pelajaran Sejarah Kebudayaan Islam, dengan begitu meningkatnya motivasi belajar dan kemampuan bercerita. Metode kisah dapat menciptakan suasana belajar yang menarik, maka peserta didik akan merasakan senangnya belajar. Dengan begitu, dalam diri peserta didik akan muncul keinginan atau hasrat yang berupa dorongan rasa ingin tahu yang disertai daya atau usaha dalam mencapai tujuan yang ingin dicapainya, inilah yang disebut munculnya motivasi belajar. Selain itu, Metode kisah menggunakan gambar dapat menguatkan daya ingat peserta didik terhadap kisah sejarah tersebut, yang dapat memberikan gambaran nyata mengenai kisah sejarah tersebut. Sehingga dalam hal ini dapat meningkatkan kemampun peserta didik dalam bercerita. Adapun tahap-tahap dalam penerapan metode kisah yang perlu diperhatikan oleh para pendidik yaitu diantaranya meliputi, perencaan, penyajian materi, korelasi, kesimpulan dan evaluasi. Mengenai perancangannya dapat disesuaikan dengan kebutuhan dan tujuan pembelajaran.
L’immortalité aux immortels
Authors: Durand Gilbert 
Published: March 2021

Dans la première moitié du xxe siècle, une tendance à la remythologisation caractérise le roman. Proust, Thomas Mann et Faulkner permettent à Gilbert Durand de dresser un portrait de « l’immortel » héros à partir de quatre traits : le temps sans mort et sans souci de sa propre fin ; le temps qui passe de l’entropie à l’infinie répétition (redondance) ; l’obsession du sang ; l’absence d’âme et d’état d’âme. Le roman perd tout sentimentalisme, tout réalisme, tout psychologisme. Le romancier mythographe accède ainsi à l’imaginaire immémorial du mythe.
(Le) Phénix de Pierre Jean Jouve ou la représentation accomplie
Authors: Castelein Machteld 
Published: March 2021

En 1928, à la suite d’une « conversion » qui le tourne vers des « valeurs spirituelles de poésie », le poète Pierre Jean Jouve (1887-1976) renie tous ses ouvrages antérieurs à 1925 et proclame le début d’une « vita nuova ». Désormais, son œuvre ne cessera de représenter cette « scène originaire » de mort et de résurrection, mise sous le signe d’une « imitation du Christ ». Parmi ces représentations, le phénix occupe une place plutôt discrète mais significative. L’article examine les différentes occurrences du symbole du phénix dans l’œuvre de traduction, de roman et de poésie de l’auteur, et y reconnaît une figure de la représentation, en tant que celle-ci exige la mort de l’objet (réel) tout en lui donnant une nouvelle vie. Le phénix jouvien apparaît comme une figure de l’« accomplissement » de cette représentation, aux multiples sens du mot. Il la montre en train de s’accomplir, via le sacrifice du corps « visible » comme présidant à un amour éternellement « audible » dans les mots. Il la représente sous une forme « accomplie » dans la prostituée qui, objet d’un meurtre sacrificiel, prend la figure d’un gouffre, lieu où toute représentation s’abîme, mais où toute représentation trouve aussi son origine et sa condition de possibilité. Il permet enfin d’en entrevoir le terme : l’oiseau, qui représente l’essence amoureuse et sacrificielle de la poésie, est d’autant plus « près » d’incarner cette essence qu’il renonce à se montrer ; il s’effacera derrière la représentation du lieu (une « forêt sacrée ») où son mystère s’est manifesté.
À l’origine de la patate douce (kumara) : entre Polynésie et Amérique, approche pluridisciplinaire
Authors: Cruchet Louis 
Published: March 2021

Il existe plusieurs faisceaux de présomption qui témoigneraient de relation entre les Polynésiens et les Amérindiens d’Amérique du Sud : il est aujourd’hui admis que les Polynésiens ont atteint l’Amérique du Sud. Si la patate douce est un indice d’anciens contacts entre la Polynésie et l’Amérique du Sud, des archéologues ont aussi trouvé sur la façade pacifique de l’Amérique du Chili des ossements de poulets polynésiens. Quelles seraient les étoiles que les Polynésiens pourraient avoir suivies pour se pourvoir en patate douce en Amérique du Sud et plus précisément au Chili, sous les latitudes où les chercheurs ont trouvé des poules polynésiennes ? L’ethnoastronomie tentera de répondre à la question de l’itinéraire de la patate douce, en soulevant l’hypothèse du rôle des étoiles comme repère spatial.
Les pouvoirs du récit
Authors: Godinho Helder 
Published: March 2021

Selon Damásio, le moi conscient se crée à partir de la capacité du cerveau à raconter, c’est-à-dire à transformer en récit les signaux et messages produits par ses diverses couches. Les mythes donnent au monde une cohérence significative qui provient de l’organisation des éléments que ses récits produisent. Les rapports au monde de toutes les espèces vivantes sont contenus dans les limites de leurs possibilités phylogénétiques qui résultent déjà d’une relation continuée pendant des millions d’années. La capacité humaine de créer des récits sur le réel (au sens le plus large du terme) doit intégrer ces éléments phylogénétiques qui se manifestent même dans les parties non conscientes du cerveau intégrées pourtant dans le récit qui construit un moi. Ce dépôt venu du fond des âges est une des causes de l’excès de sens que nous poursuivons toujours et qui est, au niveau de l’imaginaire « premier » (celui que Gilbert Durand considérait le patrimoine du sapiens) la voix de ce fonds dans ces rapports avec le texte du monde. Un récit est ainsi une façon de donner à voir l’invisible, et cette invisibilité produit un excès de sens qui cherche toujours à se manifester. Il est marqué par les cohérences et consistances des images de cet imaginaire premier qui médiatise toujours nos relations au monde et aux autres, et auquel s’ajoute les cohérences des imaginaires « seconds » des individus et des cultures.