bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic syndrome risk components and mortality after triple‐negative breast cancer diagnosis in postmenopausal women in the Women's Health Initiative
Authors: Yuan Yuan , Pan Kathy , Mortimer Joanne , Chlebowski Rowan T. , Luo Juhua , Yan Jessica E. , Yost Susan E. , Kroenke Candyce H. , Adams‐Campbell Lucile , Nassir Rami , Sun Yangbo , Shadyab Aladdin H. , Vitolins Mara Z. , Saquib Nazmus , Wild Robert A. , Manson JoAnn E. , Nelson Rebecca A. 
Published: January 2021

BackgroundTriple‐negative breast cancer (TNBC) has a high recurrence risk and poor clinical outcomes. Associations between metabolic syndrome (MetS) risk components and mortality in postmenopausal women with TNBC were examined in the Women's Health Initiative.MethodsFive hundred forty‐four postmenopausal women were diagnosed with nonmetastatic TNBC. Baseline risk components included a high waist circumference (≥88 cm), high blood pressure, hypercholesterolemia, and diabetes. Groups were categorized by the number of MetS risk components: none, 1 or 2, or 3 or 4. Hazard ratios (HRs) and 95% confidence intervals (CIs) across groups were computed with multivariable adjusted Cox models. Outcomes included breast cancer–specific mortality and breast cancer overall mortality (breast cancer followed by death from any cause). Variables in the multivariable model included age at TNBC diagnosis; race/ethnicity; income; education; clinical/observational trial status; history of oral contraceptive, hormone, and/or statin use; cancer stage; and chemotherapy and/or radiation treatment status.ResultsOf the 544 participants with TNBC, 33% had no MetS risk components (n = 178), 59% had 1 or 2 risk components (n = 323), and 8% had 3 or 4 risk components (n = 43). After a median follow‐up from diagnosis of 8.3 years, multivariable results showed that women with 3 or 4 risk components had a nonsignificantly higher risk of breast cancer mortality (HR, 2.05; 95% CI, 0.94‐4.47 trend P = .114) and a significantly higher risk of overall mortality (HR, 2.13; 95% CI, 1.22‐3.71; trend P = .006) versus women with 0 risk components.ConclusionsPostmenopausal women with TNBC and 3 or 4 MetS risk components have a nonsignificantly higher breast cancer mortality risk and a significantly higher overall mortality risk, likely because of negative influences of metabolic risk factors on several causes of death.
A new efficient multi‐task applications mapping for three‐dimensional Network‐on‐Chip based MPSoC
Authors: Gaffour Khadidja , Benhaoua Mohammed Kamel , Benyamina Abou El Hassan , Singh Amit Kumar 
Published: January 2021

SummaryThree‐dimensional Network‐on‐Chip (3D NoC) is a promising solution for solving 2D NoC problems while optimizing the system's performance. Mapping applications in 3D NoC is a crucial step as it has a significant impact on overall system performance. Moreover, multi‐task supported processing elements (PEs) are needed to run multiple applications and provide more scalability. Most of the existing 3D mapping approaches consider only the single‐task platform. In this paper, we propose an efficient multi‐task mapping algorithm targeting regular 3D NoC that allows an incremental mapping and parallel execution of many applications onto different partitions on the 3D NoC. The proposed mapping algorithm is composed of three main steps aiming to reduce the communications overhead, exploiting the benefits of vertical links and improving the performances. The algorithm has been evaluated with various random and realistic benchmarks and compared with existing mapping algorithms for 3D NoC. The experimental results demonstrate that the proposed mapping strategy achieves significant performance in terms of communication cost, energy consumption and execution time.
Cover Feature: DFT and IsoStar Analyses to Assess the Utility of σ‐ and π‐Hole Interactions for Crystal Engineering (2/2021)
Authors: Jonathan Mooibroek Tiddo 
Published: January 2021

AbstractThe front cover artwork is is provided by Tiddo J. Mooibroek. The image shows the IsoStar distributions of carbonyl fragments around several σ‐ and π‐hole donors. Such analyses and DFT calculations were used to assess the utility of several σ‐/π‐hole interactions for crystal engineering. Read the full text of the Article at 10.1002/cphc.202000927.
Stem Cell−Laden Coaxially Electrospun Fibrous Scaffold for Regenerative Engineering Applications
Authors: Nagiah Naveen , Franchi Federico , Peterson Karen , Rodriguez‐Porcel Martin 
Published: January 2021

AbstractStem cell−based therapies for various ailments have attracted significant attention for over a decade. However, low retention of transplanted cells at the damaged site has hindered their potential for use in therapy. Tissue engineered grafts with fibrillar structures mimicking the extracellular matrix (ECM) can be potentially used to increase the retention and engraftment of stem cells at the damaged site. Moreover, these grafts may also provide mechanical stability at the damaged site to enhance function and regeneration. Among all the methods to produce fibrillar structures developed in recent years, electrospinning is a simple and versatile method to produce fibrous structures ranging from a few nanometers to micrometers. Coaxial electrospinning enables production of a mechanically stable core with a cell‐binding sheath for enhanced cell adhesion and proliferation. Furthermore, this process provides an alternative to functionalized engineered scaffolds with specific compositions. The present article describes the protocol for developing a polycaprolactone (PCL) core and gelatin/gelatin methacrylate (GelMA) sheath laden with stem cells for various regenerative engineering applications. © 2021 Wiley Periodicals LLC.This article was corrected on 18 July 2022. See the end of the full text for details.Basic Protocol 1: Uniaxial PCL electrospinningBasic Protocol 2: Coaxial electrospinningSupport Protocol 1: Scaffold characterization for Basic Protocols 1 and 2Basic Protocol 3: Cell seeding on uniaxial and coaxial electrospun scaffolds and MTS assaySupport Protocol 2: Preparation of scaffold with cells for scanning electron microscopy
Phase Transition and Dielectric Response Originating from Disorder‐Order Transition in the In‐Based Organic‐Inorganic Hybrid Material [NH3(CH2)5NH3][InCl5(H2O)] ⋅ H2O
Authors: Zhang Yin‐Qiang , Li Min , Xu Guan‐Cheng 
Published: January 2021

AbstractThe new organic‐inorganic hybrid material [NH3(CH2)5NH3][InCl5(H2O)] ⋅ H2O (1) was successfully synthesized and the reversible phase transition with Curie temperature of 239.2 K was determined by differential scanning calorimetry (DSC) measurement. Moreover, the variable‐temperature single‐crystal X‐ray diffraction analyses demonstrate that the title compound crystallizes in the Pnma at 280 K. As the temperature drops below Tc, the space group of 1 transforms to the P21/n. Structural analyses reveal that the disorder‐order transformation of the organic [NH3(CH2)5NH3]2+ cation accounts for the phase transition of compound 1. And the dielectric property shows an anomaly near Tc as well. These findings will promote the exploration and construction of the indium(III) based phase transition materials.
Synthesis of (±)‐epi‐Jungianol by the Gold(I)‐Catalyzed Propargyl Claisen Rearrangement/Hydroarylation Cascade Reaction of Propargyl Vinyl Ethers
Authors: Rinaldi Antonia , Langé Vittoria , Scarpi Dina , Occhiato Ernesto G. 
Published: January 2021

AbstractThe synthesis of (±)‐epi‐jungianol was successfully carried out by the gold(I)‐catalyzed propargyl Claisen rearrangement/hydroarylation cascade reaction of suitably substituted propargyl vinyl ethers as the key step to form the indane skeleton. Two routes were compared, which involved substrates with a different degree of substitution on the vinyl moiety. The one based on a propargyl vinyl ether bearing an unsubstituted vinyl moiety, despite entailing two additional steps, provided the final compound in a higher overall yield. A method for the preparation of acid sensitive propargyl vinyl ethers with an α‐alkyl‐substituted vinyl moiety and their reactivity under gold catalysis is also reported.
Enhancement of heat extraction from solar ponds by using twisted coil‐tubes
Authors: J.H. Rawa Muhyaddin , A. Al‐Turki Yusuf , H. Abu‐Hamdeh Nidal , Khoshvaght‐Aliabadi Morteza , Alimoradi Ashkan 
Published: January 2021

AbstractGenerally, coil‐tubes are utilized to extract heat from solar ponds. There are different coil‐tubes in which their thermal and hydraulic characteristics depend on configuration and geometrical parameters. In this study, the performance of three well‐known coil‐tubes, namely helical, colubrine, and spiral, as the core of solar ponds is investigated at both smooth and twisted forms. Moreover, different levels of coil‐pitches and twist‐lengths are examined to explore the effects of geometrical parameters. First, the validity of the results is checked by the previous correlations proposed for the coil‐tubes. A good agreement is found, so that the average absolute deviation is about 6%. The results show that the heat extraction is affected by the configuration of coil‐tubes so that at the same geometrical parameters and operating conditions, the highest values are obtained for the spiral coil‐tube and the helical and colubrine coil‐tubes come in the second and third, respectively. It is found that, in all cases, twisting walls lead to higher rates of heat extraction. The enhancement range for the helical, colubrine, and spiral coil‐tubes is 0.3–19.8%, 0.3–46.1%, and 0.6–27.0%, respectively. At the same time, the pumping power augments in the range of 1.0–31.7%, 0.6–70.1%, and 0.4–43.5%. Furthermore, the models with lower level of coil‐pitch and twist‐length provide higher values of heat extraction and pumping power. At the considered ranges, the greatest overall performance is obtained for the colubrine coil‐tube with high coil‐pitch and twist‐length, which presents the performance index of 1.14.
Validation of brownie baking step for controlling Salmonella and Listeria monocytogenes
Authors: Unger Phoebe , Channaiah Lakshmikantha H. , Singh Arshdeep , Singh Sekhon Amninder , Babb Monipel , Yang Yaeseol , Michael Minto 
Published: January 2021

AbstractPathogens, such as Salmonella and Listeria monocytogenes, can survive under the dry environment of flour for extended periods of time and could multiply when flour is hydrated to prepare batter or dough. Therefore, inactivation of these pathogens during the cooking/baking step is vital to ensure the microbiological safety of bakery products such as brownies. The aim of this research was to validate a simulated commercial baking process as a kill‐step for controlling Salmonella and L. monocytogenes in brownies and to determine thermal inactivation parameters of these pathogens in brownie batter. Independent studies were conducted in a completely randomized design for each pathogen. All‐purpose flour was inoculated with a 5‐serovar Salmonella and 3‐strain L. monocytogenes cocktails. For baking validation, brownie batters were prepared from inoculated flour, and cooked in the oven set at 350°F (176.7°C) for 40 min followed by 15 min of ambient air cooling. For calculating D‐values, brownie batter was transferred into thermal‐death‐time disks, sealed, and placed in hot‐water baths. The samples were held for pre‐determined time intervals in hot‐water baths and immediately transferred to cold‐water baths. Microbial populations were enumerated using injury‐recovery media. At the end of baking, Salmonella and L. monocytogenes populations decreased by 6.3 and 5.9 log CFU/g, respectively. D‐values of Salmonella and L. monocytogenes cocktails were 53.4 and 37.5 min at 64°C; 27.2 and 16.9 min at 68°C; 10.7 and 9.1 min at 72°C; and 4.6 and 7.3 min at 76°C; respectively. The z‐values of Salmonella and L. monocytogenes cocktails were 11.1 and 16.4°C, respectively. This study can be used as a supporting document for the validation of similar brownie baking processes to control Salmonella and L. monocytogenes. The data from this study can also be employed for developing basic prediction models for the survival and thermal resistance of these pathogens during brownie baking step.
Does increasing health care access reduce disability insurance caseloads? Evidence from the rural United States
Authors: Anstreicher Garrett 
Published: January 2021

AbstractThis paper leverages the expansion of the United States' Community Health Center program over the 21st century to investigate whether improved access to health care reduces disability insurance (DI) participation at the county level. I find that the introduction of a health center that specializes in mental health and substance abuse services is associated with a 0.09 to 0.40 percentage point reduction in working‐age DI enrollment in rural counties. A cost‐benefit analysis indicates that the money saved from reduced program participation can account for more than a third of the cost the federal government faces in funding well‐targeted health care access initiatives.
Redefining risk of contralateral cervical nodal disease in early stage oropharyngeal cancer in the human papillomavirus era
Authors: Smith Andrew W. , Gallitto Matthew , Lehrer Eric J. , Wasserman Isaac , Gupta Vishal , Sharma Sonam , Liu Jerry T. , Posner Marshall , Misiukiewicz Krzysztof , Westra William H. , Genden Eric M. , Haidar Yarah , Yao Mike , Teng Marita S. , Miles Brett A. , Bakst Richard L. 
Published: January 2021

AbstractBackgroundThe optimal extent of surgery and/or radiation to the contralateral lymph node region is unknown in early‐stage human papillomavirus (HPV)–related oropharyngeal squamous cell carcinoma (OPSCC).MethodsTo investigate the pathologic incidence of and risk factors for contralateral nodal disease (CND) in cT1‐T2 HPV‐related OPSCC treated with transoral robotic surgery (TORS) and bilateral neck dissection (BND), the records of 120 patients were reviewed.ResultsEleven patients displayed pathologic contralateral nodal disease (pCND), including 7.1% of tonsil and 10.9% of base of tongue (BOT) cases. Medial hemistructure involvement and cN2 disease were significantly associated with pCND. Zero cN0 patients had pCND, and on multivariate analysis only cN classification remained significantly associated with pCND. Four percent of BOT patients and 2% of tonsil patients with a well‐lateralized primary and cN0/N1 neck demonstrated pCND.ConclusionsHPV‐related OPSCC that are cN0‐N1 have exceedingly low rates of pCND. Well‐lateralized HPV‐related BOT primaries with limited clinical nodal disease may be candidates for ipsilateral only treatment.
Role of the reuniens and rhomboid thalamic nuclei in anxiety‐like avoidance behavior in the rat
Authors: Linley Stephanie B. , Athanason Alexandria C. , Rojas Amanda K.P. , Vertes Robert P. 
Published: January 2021

AbstractThe nucleus reuniens (RE) and rhomboid (RH) nuclei of the ventral midline thalamus are reciprocally connected with the prefrontal cortex (PFC) and the hippocampus (HF) and serve as key intermediaries between these structures, regulating cognitive and emotional behaviors. Regarding affective behavior, several recent reports have described the involvement of RE/RH in the acquisition and retention of conditioned fear, but little is known regarding their role (RE/RH) in anxiety‐like behaviors. We examined the role of RH/RE on avoidance and defensive behaviors in male Long Evans rats using the elevated plus maze (EPM). We found that the reversible suppression of RE/RH with muscimol increased avoidance behavior to the open arms of the plus maze as shown by: (a) significant reductions in open arm entries; (b) reductions in the mean duration of time spent in the open arms; and (c) significant increases in retreats during open arm exploration. This was coupled with decreases in the number of head dips in the maze. Consistent with these behavioral effects, a single exposure of naïve rats to the plus maze produced significant increases in c‐fos expression selectively in RE and RH of midline thalamic nuclei. We posit that RE/RH normally acts to optimize adaptive responses to anxiety‐eliciting situations, and disruptions of RE/RH produce severe deficits in coping behaviors—or as shown here increases in avoidance/defensive behaviors. In sum, the present results establish a novel role for RE/RH in anxiety‐like avoidance behavior. In addition to its role in attention, working memory, and executive control, RE/RH also regulates adaptative responses to not only fear but also to anxiogenic stimuli. As such, dysfunction of RE/RH may contribute to the amalgamation of symptoms common to many mental health disorders including anxiety, depression, schizophrenia, and PTSD.
Enhancement of condensate water quantity and coefficient of performance of an air conditioning system: An experimental study
Authors: Meher Raghavarapu Satya , Jaikumar Sagari 
Published: January 2021

AbstractThe objective of the present work is to increase the quantity of condensate water from atmospheric air during the air conditioning (A/C) process by using two techniques: increasing moisture content in atmospheric air by adding steam and passing compressed air instead of atmospheric air, respectively. The experiment was performed with both capillary valve and thermostatic expansion valve operations for assessing the volume flow rates (VFRs) of condensate and coefficient of performance (COP) concerning the air A/C arrangement. The control valve operated for the steam supply case was at half valve opening and one‐fourth opening, respectively. The R‐22 refrigerant was used in this study. From this study, it was perceived that the condensate water quantity was increased by adding the moisture to the inlet air for the A/C system simultaneously with the usage of compressed air. Furthermore, the COP of the system was also compared to normal atmospheric air admission conditions. The compressed air and steam admission to the A/C system has shown a tremendous increase in COP together with the VFR of the system rather than atmospheric air admission conditions.
The impact of IFRS complexity on analyst forecast properties: The moderating role of high quality audit
Authors: Miah Muhammad Shahin , Jiang Haiyan , Rahman Asheq , Stent Warwick 
Published: January 2021

AbstractThis paper examines the impact of International Financial Reporting Standards (hereafter IFRS) complexity on analyst forecast properties including forecast errors, forecast dispersion and forecast revision. Because high‐quality audit is likely to moderate the effect of complexity on analyst forecast properties, Industry Specialization (ISP) as a proxy for high quality audit is introduced as a moderating variable in this paper. The complexity of individual IFRS standards is measured based on IFRS reconciliation statements capturing the adjustments on accounts affected by the changes in accounting standards. We analyze 322 companies listed on the Australian Securities Exchange (ASX). Our results suggest that all IFRS standards are not equally complex. A few standards are relatively more complex. These standards have a positive effect on analyst forecast errors, forecast dispersion and forecast revision. In addition, we find that high quality audit (proxied by city‐level industry specialist auditors) can mitigate the adverse impact of IFRS complexity on analyst forecast errors but not on forecast dispersion and revision. More interestingly, the mitigating effect of high quality audit is restricted to only a group of companies exposed to a higher level of aggregate IFRS complexity. The findings of our study contribute to the IFRS literature by identifying the most complex accounting standards. Secondly, this study provides an ex‐ante experiment in IFRS adoption, which can be used by adopting countries to understand the impact of IFRS on the analyst forecasts. Finally, our study helps regulators to understand the effects of the complexity of accounting standards on users of financial statements.
Push–pull effect to improve the electronic and optical properties of [7] circulene
Authors: Dana Payam , Shamlouei Hamid Reza , Maleki Afsaneh , Shirvan Sadif A. 
Published: January 2021

AbstractIn the present research, an electron donor‐acceptor (push‐pull) compound based on [7] circulene was studied using density functional theory (DFT) methods. The electron donor and acceptor units were attached to [7] circulene to improve optical properties. It was demonstrated that the band gap of [7]circulene molecule was lowered in electron donor and acceptor groups' presence, also the CN‐CIR7‐NHLi and CF3‐CIR7‐NHLi molecules have the lowest values of the band gap. It was observed that the optical properties of [7]circulene molecule was improved in the presence of electron donor and acceptor units. Between these units, the ‐CN and ‐CF3 as electron acceptors and ‐NHLi substituents as electron donor groups have higher enhancements on optical properties of circulene which is corresponding to the results obtained for energy gap values. The electric dipole moment (𝜇D) and the charge transfer, the electronic properties, polarizability (α), and first hyperpolarizability (β) values of the investigated molecules have been also computed. The results of this research may be useful in designing new materials applicable as improved photosensitizer and photodynamic therapy. All calculations and analyses are carried out by using DFT and dependent time DFT (TD‐DFT) with the B3LYP/6–311G (d,p) model in the Gaussian 09 software packages.
Antimycotic nail polish based on humic acid‐coated silver nanoparticles for onychomycosis
Authors: Dantas Ketheleen N M , Andrade Lucas R , Lisboa Erika , Santana Victoria L , Santos André L S , Mello Thaís P , Sangenito Leandro S , Lima Álvaro S , Fricks Alini T , Begnami Andreza F , Cano Amanda , Zielinska Aleksandra , Soares Cleide M F , Souto Eliana B , Severino Patrícia 
Published: January 2021

AbstractBACKGROUNDThe objective of this work was the development of silver nanoparticles (AgNPs) coated with humic acid (HA) and their incorporation into an enamel for antifungal activity. AgNPs were synthesized by chemical reduction using sodium borohydride as a reducing agent and coated with HA. Uncoated AgNPs were synthesized as control. AgNPs and HA‐AgNPs were characterized by ultraviolet–visible spectrophotometry, differential scanning calorimetry, dynamic light scattering, Fourier‐transform infrared spectroscopy (FTIR), atomic force microscopy and X‐ray diffraction (XRD). Size of AgNPs and HA‐AgNPs was recorded within the nano range, showing HA‐AgNPs’ higher stability than non‐coated particles by presenting a single plasmatic band around 400 nm.RESULTSThermal analysis showed conjugated endothermic peaks, which confirms the compatibility of HA‐AgNPs. FTIR depicted absorptions between 1300 and 1000 cm−1 (CC, ArH, respectively), demonstrating that HA is adsorbed onto AgNPs. Thermogravimetric analysis showed that HA does not alter the reduction in mass loss of AgNPs, while it was found by XRD that adding HA promoted the formation of more amorphous AgNPs. The effectiveness of HA‐AgNPs was evaluated against three different fungal species. Minimum inhibitory concentration assays showed that ~0.5 mmol L−1 AgNPs was able to inhibit dermatophyte species growth. HA‐AgNPs were incorporated into a commercial enamel at a concentration of 8% and their organoleptic characteristics, drying time, centrifugation test and thermal stress were evaluated. Enamels with AgNPs kept their physicochemical properties over 21 days of storage.CONCLUSIONHA‐AgNP nail polish is thus proposed as an innovative material for onychomycosis infections. © 2021 Society of Chemical Industry