bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inherited Continental Zircons in Oceanic Rocks – True or False
Authors: Bjerga Anders , Stubseid Håvard , Pedersen Leif-Erik , Pedersen Rolf Birger 
Published: August 2021

Abstract
Many studies have reported U-Pb dates of zircons that are older than the rocks that contain them, and they are therefore thought to be inherited from older rock complexes. Their presence has profound geodynamic implications and has been used to hypothesize about concealed micro-continents, continental crust beneath ocean islands, and recycling of continental material in the mantle beneath mid-ocean ridges. However, there is skepticism in the scientific community whether these zircons are truly inherited from crustal fragments or represent contaminants from sample preparation and processing. In this study, we combine single zircon U-Pb dates with structural radiation damage determined by Raman spectroscopy from a Pliocene mid-ocean ridge gabbro and show that the thermal history of Precambrian zircons found in the sample contradicts an inherited origin. To confirm that our approach allows distinction between contamination and true inherited zircons, we investigated igneous rocks that formed during the opening of the Atlantic Ocean and find that the calculated radiation damage age of old inherited grains corresponds with the crystallization dates of the young magmatic zircons.
Assessing the Rigidity of the River Continuum Concept to Fish Species in a Fluvially Dominated Southern African Coastal System
Authors: Nashima Festus P. , Strydom Nadine A. , Lamberth Stephen J. 
Published: August 2021

Abstract
A continuous gradient of physical and biological processes exists within a river system from headwaters to mouth, according to the River Continuum Concept. In this study, the River Continuum Concept was used to compare patterns in fish assemblages and diversity trends to Remane predictions. The findings show that species diversity is low near the estuary's mouth and increases upstream. While the presence of several marine and estuarine species increased species diversity upstream in the river due to the dominance of freshwater fishes, it decreased downstream due to the presence of several marine and estuarine species. These patterns are consistent with the biogeographical trend of decreasing species richness along the South African coast from east to west. Based on the findings of this study, the River Continuum Concept ignores plasticity, which is evident in species that use transitional waters. As a result, the concept is insufficiently valid for the Orange River Estuarine Continuum, and a new concept known as the “River-Estuarine Continuum” has been proposed.
Three-dimensional Analysis of Mandible Ramus Morphology and Transverse Stability After Intraoral Vertical Ramus Osteotomy
Authors: Huang Luo , Tang Shan , Yan Jing , Liu Yaoran , Piao ZhengGuo 
Published: August 2021

Abstract
Objectives: The purpose of this study was to investigate short- and long-term postoperative changes of both morphology and transverse stability in mandibular ramus after intraoral vertical ramus osteotomy (IVRO) in patients with jaw deformity using three-dimensional (3D) orthognathic surgery planning treatment software for measurement of distances and angles.Study Design: This retrospective study included consecutive patients with skeletal Class III malocclusion who had undergone intraoral vertical ramus osteotomy and computed tomography images before (T0), immediately after (T1), and one year after (T2) surgery. Reference points, reference lines and evaluation items were designated on the reconstructed 3D surface models to measure distances, angles and volume. The average values at T0, T1, T2 and time-dependent changes in variables were obtained.Results: After surgery, the condylar length, ramal height, mandibular body length and mandibular ramus volume were significantly decreased (P < .01), while clinically insignificant change was observed from T1 to T2. The angular length was increased immediately after surgery (P < .05), but it was decreased 1 year after surgery (P < .05). Lateral ramal inclination showed significant increase after surgery (P < .05) and maintained at T2.Conclusion: Changes in the morphology of the mandibular ramus caused by IVRO do not obviously bring negative effect on facial appearance. Furthermore, despite position and angle of mandibular ramus changed after IVRO, good transverse stability was observed postoperatively. Therefore, IVRO technique can be safely used without compromising esthetic results.
Hybridization of Tumor Homing and Mitochondria-Targeting Peptide Domains to Design Novel Dual-Imaging Self-Assembled Peptide Nanoparticles for Theranostic Applications
Authors: Rizvi Syed Faheem Askari , Ali Azam , Ahmad Munir , Mu Shuai , Zhang Haixia 
Published: August 2021

Abstract
A unique dual-targeting dual-imaging peptide-based nanoprobe was successfully designed by investigating the cyclic heptapeptide having Arg-Gly-Asp-Lys-Leu-Ala-Lys sequence composed of RGD homing motif and KALK mitochondria targeting motif linked via amide bond. The designed peptide was further modified through covalent linkage, characterized and self-assembled to form spherical nanoparticles. The novel Cy5.5-SAPD-99mTc nanoparticles were tested in vitro for cytotoxicity, cellular uptake, biocompatibility and apoptosis inducing functionalities. The cellular internalization, enhanced cytotoxicity and selective receptor binding capabilities against U87MG cells, excellent dual-imaging potential, improved apoptosis inducing feature by damaging mitochondria and in vivo preclinical investigations suggested that our newly designed novel dual-targeting dual-imaging nanoparticles may serve as an admirable theranostic probe to treat brain tumor glioblastoma multiforme.
Time Course of Changes in Vision-Related Quality of Life following Intravitreal Ranibizumab Treatment for Branch Retinal Vein Occlusion
Authors: Morikawa Shohei , Okamoto Fumiki , Murakami Tomoya , Sugiura Yoshimi , Hiraoka Takahiro , Okamoto Yoshifumi , Oshika Tetsuro 
Published: August 2021

Abstract
Purpose: To assess the vision-related quality of life (VR-QOL) following intravitreal ranibizumab (IVR) for branch retinal vein occlusion (BRVO) and to evaluate subscale items of the VR-QOL.Methods: In this prospective observational multicenter study, 38 patients who underwent IVR treatment for unilateral BRVO and 28 age-matched healthy subjects were chosen. The 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) and best-corrected visual acuity (BCVA) were examined before and at 3, 6, and 12 months after treatment.Results: The VFQ-25 composite score and BCVA significantly improved from 3 to 12 months after IVR treatment (P < 0.05), such that there was no significant difference between the BRVO and control groups at 12 months. All subscales of the VFQ-25, except “general health,” significantly improved after treatment, while “near vision” and “mental health” were worse than those in healthy subjects (P < 0.05). Patients with superior BRVO had a lower “near vision” score than healthy subjects after treatment (P < 0.05). BCVA in the treated eye and fellow eye had no significant relationship with the VFQ-25 composite score before and after treatment.Conclusions: The VR-QOL of patients with BRVO improved with IVR treatment and was comparable to that of healthy subjects after 12 months. Superior BRVO particularly affected near vision for a low level.
Combined Therapy for Paclitaxel and Curcumin by Nonionic Surfactant Vesicles Leading to Enhanced Efficacy of Chemotherapy in Ovarian Cancer Cells Through Inhibiting the Serine/threonine Kinase Akt and Nuclear Factor Kappab Activity
Authors: alemi ashraf , Karamallah Mojtaba Haghi , Hosseini Seyed Ahmad , Tahery Noorollah , Radmanesh Esmat , Malihi Reza , Farrokhifar Majid , Farokhifar Saeed , Karamallah Somayeh Haghi , Zare-Zardini Hadi , Farokhifar Mohammad 
Published: August 2021

Abstract
The combination therapy of cytotoxic drugs and chemosensitizing agents encapsulated in nanoparticles has been highlighted as an effective treatment for various cancers. Combination therapy is promising to produce synergistic anticancer effects, to magnify the treatment effect and overcome multidrug resistance. In this investigation, we have studied augmentation of therapeutic efﬁcacy upon c combinational treatment of paclitaxel (PCL) and curcumin (Cur), an inhibitor of nuclear factor kappa B (NF-κB), in OVCAR-3 cell. PCL and Cur were encapsulated in nanoniosome formulations. Then, the effects of nanoniosome formulations on cytotoxicity, expression profile of AKT-1 gene and NF-κB activity were evaluated. The findings showed that nanoniosomes were highly efﬁcient in delivering the PCL and Cur drugs to OVCAR-3 cell. A 3-fold and 3.6-fold reduction in Cur and PCL concentration were measured, respectively, when the Cur and PCL were administered in nanoniosomes compared to free Cur and free PCL solutions in OVCAR-3 cell. Moreover, curcumin could signiﬁcantly increase cell growth inhibition of paclitaxel so that, in presence of NioCur, the IC50 of NioPCL was diminished to ∼2.4 –fold. AKT-1 gene expression studies showed that co-administration of curcumin/paclitaxel nanoniosome formulations caused 91.2% reduction in AKT-1 gene expression compared to control group. On the other hand, this co-administration caused 79.42% reduction in the amount of NF-κB activity and a 4-fold reduction in the activity of the MDR protein pumps in cancer cells compared to the control group. Our findings demonstrate that the combination therapy of PCL with Cur using the nanoniosomes delivery is a promising strategy for breast cancer more effective therapy
Digital Light Processing 3D Printing of Surface-oxidized Si3N4 Coated by Silane Coupling Agent
Authors: Yang Ping , Sun Zhenfei , Huang Shengwu , Ou Jun , Wu Shanghua 
Published: August 2021

Abstract
Due to high light absorption and high refractive index of silicon nitride (Si3N4) ceramic, it is difficult to prepare Si3N4 slurry with favourable curing ability, high solid loading and low viscosity at the same time, and thus the high quality Si3N4 parts are hard to fabricate via Digital Light Processing (DLP). In this paper, oxidation process was used to enhance the curing behavior of Si3N4 slurry, and then silane coupling agent (KH560) was used to improve the rheological properties of the oxidized Si3N4 slurry. The effect of Si3N4 slurry with oxidation and modification on its rheological behavior, light absorption, curing ability and stability have been systematically investigated. A Si3N4 slurry with abundant photocuring ability, high solid loading, low viscosity and reliable stability was fabricated by the oxidized (1h) and KH560 (1wt.%) modified Si3N4 powders, and the dense Si3N4 ceramic parts were produced by this slurry via DLP 3D printing. Subsequently, the influence of oxidation and modification on microstructure, mechanical properties and thermal conductivity have been investigated. Finally, the performances of the DLP 3D printed samples are close to the isostatic cool pressing (ICP) fabricated samples. Consequently, DLP has well potential to fabricate high-performance Si3N4 ceramics.
Hepatic Small Extracellular Vesicles Promote Microvascular Endothelial Hyperpermeability During NAFLD via novel-miRNA-7
Authors: Zuo Rui , Ye Li-feng , Huang Yi , Song Zi-qing , Wang Lei , Zhi Hui , Zhang Min-yi , Li Jie-yi , Zhu Li , Xiao Wen-jing , Shang Hong-cai , Zhang Yang , He Rong-rong , Chen Yang 
Published: August 2021

Abstract
BackgroundA recent study has reported that patients with nonalcoholic fatty liver disease (NAFLD) are more susceptible to coronary microvascular dysfunction (CMD), which may predict major adverse cardiac events. However, little is known regarding the causes of CMD during NAFLD. In this study, we aimed to explore the role of hepatic small extracellular vesicles (sEVs) in regulating the endothelial dysfunction of coronary microvessels during NAFLD.ResultsWe established two murine NAFLD models by feeding mice a methionine-choline-deficient (MCD) diet for 4 weeks or a high-fat diet (HFD) for 16 weeks. We found that the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome-dependent endothelial hyperpermeability occurred in coronary microvessels during both MCD diet and HFD-induced NAFLD. The in vivo and in vitro experiments proved that novel-miR-7-abundant hepatic sEVs were responsible for NLRP3 inflammasome-dependent endothelial barrier dysfunction. Mechanistically, novel-miR-7 directly targeted lysosomal associated membrane protein 1 (LAMP1) and promotes lysosomal membrane permeability (LMP), which in turn induced Cathepsin B-dependent NLRP3 inflammasome activation and microvascular endothelial hyperpermeability. Conversely, a specific novel-miR-7 inhibitor markedly improved endothelial barrier integrity. Finally, we proved that steatotic hepatocyte was a main resource of novel-miR-7-contained hepatic sEVs, and steatotic hepatocyte-derived sEVs were able to promote NLRP3 inflammasome-dependent microvascular endothelial hyperpermeability through novel-miR-7.ConclusionsHepatic sEVs contribute to endothelial hyperpermeability in coronary microvessels by delivering novel-miR-7 and targeting the LAMP1/Cathepsin B/NLRP3 inflammasome axis during NAFLD. Our study brings new insights into the liver-to-microvessel cross-talk and may provide a new diagnostic biomarker and treatment target for microvascular complications of NAFLD.
Mapping the Minds of Spectators During Extreme Ritual: A Psychological Network Perspective
Authors: Fischer Ronald , Sinwongsuwat Kemtong , Tepsing Punya , Karl Johannes Alfons 
Published: August 2021

Abstract
Reactions of spectators during extreme rituals raise questions about evolutionary functions of ritual. We computed psychological network models during a large naturally occurring extreme ritual. Our aim is to identify the network structure of psychological reactions to extreme rituals in situ. Participants who observed high ordeal activities (N =1,041 Taoist-Buddhists) completed measures of social, affective, behavioral and uncertainty cognitions. Applying undirected psychometric network models, we found that 1) ritualist cognitions showed a smallworld network structure with highly interconnected nodes, 2) five robust clusters of cognitions that 3) can be organized along two major dimensions (positive vs negative valence, uncertainty beliefs vs uncertainty management) and 4) associations between clusters through linking nodes allow integration of previous theories of ritual and help to identify core cognition during ritual. Our study points towards new avenues for evolutionary theory by mapping the interdependence of experienced psychological reactions in situ.
Barriers to the Donation of Living Kidneys for Kidney Transplantation
Authors: Min Kyungok , Koo Tai Yeon , Hwang Young Hui , Yang Jaeseok 
Published: August 2021

Abstract
Since the waiting time for deceased donor kidney transplantation continues to increase, living donor kidney transplantation is an important treatment for end stage kidney disease patients. Barriers to living kidney donation have been rarely investigated despite a growing interest in the utilization of living donor transplantation and the satisfaction of donor safety. Here, we retrospectively analyzed 1,658 potential donors and 1,273 potential recipients who visited the Seoul National University Hospital for living kidney transplantation between 2010 and 2017 to study the causes of donation failure. Among 1,658 potential donors, 902 (54.4%) failed to donate kidneys. The average number of potential donors that received work-up was 1.30 ± 0.66 per recipient. Among living donor kidney transplant patients, 75.1% received kidneys after work-up of the first donor and 24.9% needed work-up of two or more donors. Donor-related factors (49.2%) were the most common causes of donation failure, followed by immunologic or size mismatches between donors and recipients (25.4%) and recipient-related factors (16.2%). Interestingly, withdrawal of donation will along with refusal by recipients or family were the commonest causes, suggesting the importance of non-biomedical aspects. The elucidation of the barriers to living kidney donation could ensure more efficient and safer living kidney donation.
Projections of North American Snow from NA-CORDEX and their Uncertainties, with a Focus on Model Resolution
Authors: McCrary Rachel , Mearns Linda , Hughes Mimi , Biner Sébastien , Bukovsky Melissa 
Published: August 2021

Abstract
Snow is important for many physical, social, and economic sectors in North America. In a warming climate, the characteristics of snow will likely change in fundamental ways, therefore compelling societal need for future projections of snow. However many stakeholders require climate change information at finer resolutions that global climate models (GCMs) can provide. The North American Coordinated Regional Downscaling Experiment (NA-CORDEX) provides an ensemble of regional climate model (RCMs) simulations at two resolutions (~0.5º and ~0.25º) designed to help serve the climate impacts and adaptation communities. This is the first study to examine the differences in end-of-21st-century projections of snow from the NA-CORDEX RCMs and their driving GCMs.
We find the broad patterns of change are similar across RCMs and GCMs: snow cover retreats, snow mass decreases everywhere except at high latitudes, and the duration of the snow covered season decreases. Regionally, the spatial details, magnitude, percent, and uncertainty of future changes varies between the GCM and RCM ensemble, but are similar between the two resolutions of the RCM ensembles. Increases in winter snow amounts at high latitudes is a robust response across all ensembles. Percent snow losses are found to be more substantial in the GCMs than the RCMs over most of North America, especially in regions with high-elevation topography. Specifically, percent snow losses decrease with increasing elevation as the model resolution becomes finer.
Optimal Release Timing of Temporary Drain Clamping to Reduce Postoperative Bleeding After Total Knee Arthroplasty With an Intraarticular Injection of Tranexamic Acid
Authors: Kim Myung Ku , Ko Sang Hyun , Nam Yoon Cheol , Jeon Yoon Sang , Kwon Won Hwan , Ryu Dong Jin 
Published: August 2021

Abstract
Background: Intraarticular injection of tranexamic acid (IA-TXA) plus drain-clamping is a preferred method of reducing bleeding after total knee arthroplasty (TKA). However, no consensus had been reached regarding the timing of clamping. The purpose of this study was to determine the optimum duration of drain-clamping after TKA with IA-TXA.Methods: We retrospectively reviewed 151 patients that underwent unilateral TKA with IA-TXA plus drain-clamping for 30 minutes (Group A, 60 patients), 2 hours (Group B, 42 patients), or 3 hours (Group C, 49 patients). Total drained volumes, hematocrit (Hct) reductions, estimated blood losses (EBLs), transfusion rates, and wound complications were reviewed.Results: Mean total drained volume, Hct reduction, EBL, and transfusion rate were significantly less in group C than in groups A or B (p < 0.01). No significant intergroup difference was found for wound-related complications. No surgical site infection or deep vein thrombosis was observed.Conclusion: IA-TXA plus drain-clamping for 3 hours is optimal for reducing blood loss with minimal complications after TKA.
Universality of ultrasonic attenuation coefficient of amorphous systems at low temperatures
Authors: Shukla Pragya 
Published: August 2021

Abstract
The competition between unretarded dispersion interactions between molecules prevailing at medium range order length scales and their phonon induced coupling at larger scales leads to appearance of nano-scale sub structures in amorphous systems. The complexity of intermolecular interactions gives rise to randomization of their operators. Based on a random matrix modelling of the Hamiltonian and its linear response to an external strain field, we show that the ultrasonic attenuation coefficient can be expressed as a ratio of two crucial length-scales related to molecular dynamics. A nearly constant value of the ratio for a wide range of materials then provides a theoretical explanation of the experimentally observed qualitative universality of the ultrasonic attenuation coefficient at low temperatures.
Gel Permeation Chromatography Process For Highly Oriented Cs3Cu2I5 Nanocrystal Film
Authors: Cheng Yu-Hong , Suzuki Rikuo , Shinotsuka Narumi , Ebe Hinako , Oshita Naoaki , Yamakado Ryohei , Chiba Takayuki , Masuhara Akito , Kido Junji 
Published: August 2021

Abstract
The emergence of green materials has attracted considerable attention in the field of optoelectronics. Copper-based lead-free halide perovskite (with a near-unity quantum yield) obtained from Cs3Cu2I5 nanocrystals (NCs) can exhibit blue emission with a wavelength of 440 nm and provide outstanding stability for various applications. However, in practical applications, colloidal dispersion purity and film quality are inadequate toward a high-performance device. In this study, antisolvent-free gel permeation chromatography is used to purify Cs3Cu2I5 NCs. The purified Cs3Cu2I5 NCs exhibit a high photoluminescent quantum yield and provide a highly oriented single-crystal film. Density functional theory calculation results indicate that the iodide-rich phase in the NCs makes them highly stable. In addition, it has been demonstrated for the first time that the mixture of polymethyl methacrylate (PMMA) and Cs3Cu2I5 NCs has waterproofing capabilities. The composite film consisting of Cs3Cu2I5 NCs and PMMA can survive in water for several days. This result opens up more possibilities for the application of these green material.
Early colorectal cancer from “de novo” carcinogenesis with submucosal invasion: a case report and review of the literature
Authors: jiang hua , he chiyi 
Published: August 2021

Abstract
Background: Colorectal cancer (CRC) mostly develops through the traditional “adenoma-carcinoma sequence”, however there is a rare “de novo” carcinogenic pathway in which cancer originates from normal mucosa. Here, we report a case of early CRC caused by “de novo” carcinogenesis with submucosal invasion and conduct a literature review of this special type of CRC.Case presentation: A 66-year-old man underwent a screening colonoscopy that revealed a polyp-like lesion (type 0-IIa+IIc in the Paris classification) approximately 0.5 cm in diameter in the descending colon. The patient underwent endoscopic submucosal dissection (ESD); postoperatively, he was pathologically diagnosed with moderately differentiated adenocarcinoma without an adenomatous component from the “de novo” carcinogenic pathway, accompanied by submucosal invasion to a depth of 600 μm. There was no venous or lymphatic permeation, and the margins were negative. A year later, follow-up examinations did not reveal tumour recurrence.Conclusions: Early “de novo” cancer has a low incidence and a low discovery rate through endoscopy. In this case report, we provide informative details about the presentation of such cancers under endoscopy and further support for the aggressive malignant potential of early “de novo” cancer. The development of advanced CRC can be effectively prevented, and the prognosis of these patients can be improved with active early treatment.