bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subjective wellbeing among older adults: the role of age-friendly facilities
Authors: Berkers E , Cloïn M , Kuunders T 
Published: October 2021

Abstract

Due to population aging, the amount of older adults in the western world is increasing. To support this growing group, policy initiatives have focused on supporting aging-in-place, which is meant to stimulate community dwelling through providing important services and facilities (WHO, 2004). In this study we link the availability of facilities to older adults' subjective wellbeing. Older adults identify facilities as important for their wellbeing (Novak & Menec, 2013) because they satisfy daily needs and stimulate social contact and physical activity (Nieboer & Cramm, 2018; Maas et al., 2009). However, it is unknown which specific services relate to the wellbeing of older adults (Stephens et al., 2020). Moreover, relatively few studies have studied positive health outcomes, including subjective wellbeing, to the living environment (Zhang & Zhang, 2017). Additionally, we test whether the relationship between the availability of services and subjective wellbeing is explained by an increased sense of mastery. Feeling of mastery over the environment and decisions is key to subjective wellbeing among elderly (Menec, Means, Keating, Parkhurst, & Eales, 2011). If older adults feel limited in their daily activities and have to rely on others because the availability of services in their immediate environment is low, they will experience a lower sense of mastery and thereby less subjective wellbeing (Chen et al., 2016). This assumption is however scarcely tested empirically. We used survey data on older adults in a Dutch province (65+) from the Health Monitor (2016). We combined this with data from Statistics Netherlands about facilities (supermarket, general practitioner, pharmacy and public transport) at the district level. Different measures of availability are included: the average available amount of services per 1 km and the average distance to facilities per district. Multilevel regression is used as our method of analysis.

Key messages
This study has as a main aim to find out which facilities influence older adult subjective wellbeing. This is important to policymakers, because it gives information for planning policies. We test whether the relationship between the availability of facilities and subjective wellbeing is explained by an increased sense of mastery.
Disability inclusiveness of government responses to COVID-19 in Brazil and Chile
Authors: Rotarou E , Serrano Malfitano AP 
Published: October 2021

Abstract

Issue/problem
People with disabilities are disproportionately exposed to the risks of COVID-19, due to underlying health conditions, as well as on account of mechanisms introduced as a response to COVID-19. This study examines the disability inclusiveness of government measures to COVID-19 in Brazil and Chile. With more than one billion people with disabilities worldwide, it is important to examine the inclusiveness of official government responses, in order to protect and mitigate the impacts of the pandemic for this population.

Description of the problem
Government responses have a direct impact on the capacity of people with disabilities to protect themselves against health-related, economic, and social consequences of the pandemic. In order to examine official measures, we conducted documentary research, using framework analysis, and studied official documents published from February 1st, 2020 until June 30th, 2021. The aim was to explore the inclusiveness of government responses in areas such as access to healthcare, and social welfare.

Results
We analysed 41 documents in total. The findings highlight that while both countries took steps to ensure access to healthcare, and relevant information, as well as financial support, they also implemented policies - or did not undertake any at all - that often resulted in an amplification of existing inequalities. Neither country included people with disabilities and their organisations in decision-making processes.

Lessons
This study illustrates how oficial government responses taken by Brazil and Chile - while positive, in several aspects - do not fully address the needs of people with disabilities. In order to ensure response to COVID-19 is disability-inclusive, it is necessary to translate recommendations into practice, consider people with disabilities both in mainstream policy and in disability-specific measures, and focus on the long-term reconstruction phase.

Key messages
People with disabilities are particularly exposed to the risks of and responses to COVID-19. Inclusive measures have been adopted but the needs of this population have not been fully addressed.
Fantastic Femininities: Metamorphosis and Resistance in the Fiction of Marie Darrieussecq and Armonía Somers
Authors: Cortellete Letícia 
Published: October 2021

Abstract
This article seeks to examine the construction of female embodied identities via metamorphosis in two works of Uruguayan and French literature: Armonía Somers’s La mujer desnuda (1950) and Marie Darrieussecq’s Truismes (1996). The internal and external transformations of these heroines are a result of bodies that refuse to be disciplined into silence and passivity, and, instead, make a spectacle of themselves, symbolically voicing their right to take up space and delight in the unacceptable – the grotesque, nudity, lust. Hence, it is not surprising that both novels, in foreshadowing new ways of being in the female body, generated scandal and controversy. Read through the lens of écriture féminine, the much-debated ambiguity of these texts can be understood as a device affirming women’s corporeal autonomy. Nevertheless, the tragic ending of these tales ultimately points to society’s persistent and violent rejection of female excess as an embodied identity.
Role of the tomato fruit ripening regulator MADS-RIN in resistance to Botrytis cinerea infection
Authors: Zheng Hui , Jin Rong , Liu Zimeng , Sun Cui , Shi Yanna , Grierson Donald , Zhu Changqing , Li Shan , Ferguson Ian , Chen Kunsong 
Published: October 2021

Abstract
Tomato MADS-RIN (RIN) transcription factor has been shown to be a master activator regulating fruit ripening. Recent studies have revealed that in addition to activating many other cell wall genes, it also represses expression of XTH5, XTH8, and MAN4a, which are positively related to excess flesh softening and cell wall degradation, which might indicate it has a potential role in pathogen resistance of ripening fruit. In this study, both wild-type (WT) and RIN-knockout (RIN-KO) mutant tomato fruit were infected with Botrytis cinerea to investigate the function of RIN in defense against pathogen infection during ripening. The results showed that RIN-KO fruit were much more sensitive to B. cinerea infection with larger lesion sizes. Transcriptome data and qRT-PCR assay indicate genes of phenylalanine ammonialyase (PAL) and chitinase (CHI) in RIN-KO fruit were reduced and their corresponding enzyme activities were decreased. Transcripts of genes encoding pathogenesis-related proteins (PRs), including PR1a, PRSTH2, and APETALA2/Ethylene Response Factor (AP2/ERF) including ERF.A1, Pti5, Pti6, ERF.A4, were reduced in RIN-KO fruit compared to WT fruit. Moreover, in the absence of RIN the expression of genes encoding cell wall-modifying enzymes XTH5, XTH8, MAN4a has been reported to be elevated, which is potentially correlated with cell wall properties. When present, RIN represses transcription of XTH5 by activating ERF.F4, a class II (repressor class) ERF gene family member, and ERF.F5. These results support the conclusion that RIN enhances ripening-related resistance to gray mold infection by upregulating pathogen-resistance genes and defense enzyme activities as well as reducing accumulation of transcripts encoding some cell wall enzymes.
Environmental drivers and trends in forage fish occupancy of the Northeast US shelf
Authors: Suca Justin J , Deroba Jonathan J , Richardson David E , Ji Rubao , Llopiz Joel K 
Published: October 2021

Abstract
The Northeast US shelf ecosystem is undergoing unprecedented changes due to long-term warming trends and shifts in regional hydrography leading to changes in community composition. However, it remains uncertain how shelf occupancy by the region's dominant, offshore small pelagic fishes, also known as forage fishes, has changed throughout the late 20th and early 21st centuries. Here, we use species distribution models to estimate the change in shelf occupancy, mean weighted latitude, and mean weighted depth of six forage fishes on the Northeast US shelf, and whether those trends were linked to coincident hydrographic conditions. Our results suggest that observed shelf occupancy is increasing or unchanging for most species in both spring and fall, linked both to gear shifts and increasing bottom temperature and salinity. Exceptions include decreases to observed shelf occupancy by sand lance and decreases to Atlantic herring's inferred habitat suitability in the fall. Our work shows that changes in shelf occupancy and inferred habitat suitability have varying coherence, indicating complex mechanisms behind observed shelf occupancy for many species. Future work and management can use these results to better isolate the aspects of forage fish life histories that are important for determining their occupancy of the Northeast US shelf.
Measurement and causal identification in constitutional law: A reply to Niels Petersen and Konstantin Chatziathanasiou
Authors: Chilton Adam , Versteeg Mila 
Published: October 2021

Abstract
The past few decades have seen a trend toward empirical constitutional law scholarship. In a new article, Niels Petersen and Konstantin Chatziathanasiou take stock of this emerging field and suggest that this body of research may be all “smoke and mirrors.” They focus on explaining two well-documented potential problems with empirical research using observational data—omitted variable bias and measurement error—and argue that these problems are severe enough to call into question the growing body of cross-national research on the spread and effect of constitutional provisions. But while Petersen and Chatziathanasiou’s article points out genuine obstacles for empirical research in constitutional law, it fails to accurately document the way that these issues have been explained and addressed by the existing literature. In this reply, we make four points about the state of the empirical literature in comparative constitutional studies. First, we explain that the problems identified by Petersen and Chatziathanasiou have already been extensively documented and are the subject of ongoing conversation among those working in the field. Second, we describe the work that researchers have done to address these problems. Third, we argue that the methodological pluralism that Petersen and Chatziathanasiou advocate for as a way forward for the field is already well underway. Finally, we suggest that evaluating an entire literature, like Petersen and Chatziathanasiou seek to do in their article, is best done through the use of a “systematic review,” to ensure that the evaluation will offer a fair characterization of the field.
Vanishing Theorems for Three-folds in Characteristicp&gt; 5
Authors: Bernasconi Fabio , Kollár János 
Published: October 2021

AbstractWe prove Grauert–Riemenschneider–type vanishing theorems for excellent divisiorally log terminal threefolds pairs whose closed points have perfect residue fields of positive characteristic $p&gt;5$. Then we discuss applications to dlt singularities and to Mori fiber spaces of three-folds.
Identification of microenvironmental niches for hematopoietic stem cells and lymphoid progenitors—bone marrow fibroblastic reticular cells with salient features
Authors: Omatsu Yoshiki , Nagasawa Takashi 
Published: October 2021

Abstract
Most lineages of blood cells, including immune cells, are generated from hematopoietic stem cells (HSCs) in bone marrow throughout adult life. Since HSCs cannot expand on their own, they require and contact the special microenvironments, termed niches for their maintenance. HSC niches comprise supportive cells that provide adjacent HSCs with critical signals, including cytokines. Although bone marrow microenvironments have been thought to be complex, recent studies have demonstrated that the bone marrow-specific population of fibroblastic reticular cells with long processes, termed CXC chemokine ligand 12 (CXCL12)-abundant reticular (CAR) cells, which overlap strongly with leptin receptor (LepR)-expressing (LepR+) cells, is the major cellular component of niches for HSCs and lymphoid progenitors. CAR cells have salient features, expressing much higher levels of critical HSC niche factors than any other cell populations and function as self-renewing mesenchymal stem cells. Human counterpart of CAR cells is present and affected in diseases, including leukemia. Foxl1+ telocytes recently identified as the niche for intestinal stem cells share some features with CAR cells, suggesting that CAR cells might serve as a prototype for fibroblastic reticular cells creating niche for long-lived cells, including tissue stem cells and memory lymphocytes. These findings provided the basis for future mechanistic studies on the cross-talk between hematopoietic cells and microenvironments in both health and disease.
DNAM-1 promotes inflammation-driven tumor development via enhancing IFN-γ production
Authors: Nakamura-Shinya Yuho , Iguchi-Manaka Akiko , Murata Rikito , Sato Kazuki , Vo Anh Van , Kanemaru Kazumasa , Shibuya Akira , Shibuya Kazuko 
Published: October 2021

AbstractDNAM-1 is an activating immunoreceptor on T cells and natural killer (NK) cells. Expression levels of its ligands, CD155 and CD112, are up-regulated on tumor cells. The interaction of DNAM-1 on CD8+ T cells and NK cells with the ligands on tumor cells plays an important role in tumor immunity. We previously reported that mice deficient in DNAM-1 showed accelerated growth of tumors induced by the chemical carcinogen 7,12-dimethylbenz[a]anthracene (DMBA). Contrary to those results, we show here that tumor development induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) together with DMBA was suppressed in DNAM-1–deficient mice. In this model, DNAM-1 enhanced IFN-γ secretion from conventional CD4+ T cells to promote inflammation-related tumor development. These findings suggest that, under inflammatory conditions, DNAM-1 contributes to tumor development via conventional CD4+ T cells.
Clinical exposure–response relationship of cefepime/taniborbactam against Gram-negative organisms in the murine complicated urinary tract infection model
Authors: Lasko Maxwell J. , Nicolau David P. , Asempa Tomefa E. 
Published: October 2021

AbstractObjectivesComplicated urinary tract infections (cUTIs) are frequently encountered in hospitals and ICUs. Increasingly, the causative pathogens harbour enzymatic resistance mechanisms. Taniborbactam is a novel β-lactamase inhibitor with activity against Ambler class A, B, C and D β-lactamases. Herein, we assessed the efficacy of cefepime alone and the combination cefepime/taniborbactam in a neutropenic murine cUTI model.MethodsEighteen cefepime-resistant clinical isolates (9 Enterobacterales, 3 Pseudomonas aeruginosa and 6 Stenotrophomonas maltophilia; cefepime MIC = 32 to &gt;512 mg/L) were assessed. Cefepime/taniborbactam MICs ranged from 0.06 to 128 mg/L. Human-simulated plasma regimens (HSRs) of cefepime alone and in combination with taniborbactam were developed in the murine cUTI model. The efficacy of cefepime HSR and cefepime/taniborbactam HSR was determined as the change in log10 cfu/kidney at 48 h compared with 48 h controls.ResultsMean ± SD initial bacterial burden was 5.66 ± 0.56 log10 cfu/kidney, which increased to 9.05 ± 0.39 log10 cfu/kidney at 48 h. The cefepime HSR was ineffective, as bacterial burden was similar to untreated controls (−0.14 ± 0.40 change in log10 cfu/kidney). In contrast, cefepime/taniborbactam exhibited substantial killing, with log10 cfu/kidney changes of −5.48 ± 1.3, −4.79 ± 0.3 and −5.04 ± 0.7 for ESBL/AmpC-, KPC- and OXA-48-harbouring Enterobacterales, respectively. Cefepime/taniborbactam also exhibited robust killing of P. aeruginosa (−6.5 ± 0.26) and S. maltophilia (−5.66 ± 0.71).ConclusionsHumanized exposures of cefepime/taniborbactam achieved robust killing of Enterobacterales, P. aeruginosa and S. maltophilia harbouring ESBL, AmpC, KPC and/or OXA-48. These data support the role of cefepime/taniborbactam for cUTI treatment for cefepime/taniborbactam MICs up to 32 mg/L.
Validation of the 3M™ Environmental Scrub Sampler with Wide-Spectrum Neutralizer: AOAC Performance Tested MethodSM 022104
Authors: Rosauer Micki L , Silbernagel Karen M , Thompson Wesley 
Published: October 2021

Abstract

Background
The 3M™ Environmental Scrub Sampler with 10 mL Wide Spectrum Neutralizer is a nonspecific sampling device intended for use for environmental monitoring surface sampling.

Objective
The aim was to evaluate 3M Wide Spectrum Neutralizer using the 3M Environmental Scrub Sampler for AOAC® Performance Tested MethodsSM (PTM) certification.

Methods
Matrix studies, inclusivity/exclusivity, product consistency/stability, neutralization, and robustness testing were conducted for Salmonella and Listeria species. Stainless steel, sealed concrete, and plastic environmental surfaces were evaluated in the matrix study comparing the performance of the 3M™ method for sample collection to that of the U.S. Food and Drug Administration (FDA) Bacteriological Analytical Manual (BAM) reference methods. Four classes of sanitizers, namely quaternary ammonium, high acid, hydrogen/peroxyacetic acid and chlorine/bleach-based, were assessed in the neutralization study following ASTM E1054 - 08, Standard Test Methods for Evaluation of Inactivators of Antimicrobial Agents. The other testing parameters followed typical PTM study design.

Results
In matrix studies the 3M sampling device demonstrated no significant differences between candidate and reference sampling method results. All inclusivity organisms were detected, and all exclusivity organisms were excluded, for both Salmonella and Listeria strains when tested by the appropriate FDA BAM detection method. Robustness, product consistency, and stability studies showed that the sampling device is not affected by lot or testing parameter differences. The Wide Spectrum Neutralizer was proven to effectively neutralize sanitizers at the concentrations tested and was itself shown to be nontoxic and did not affect target microorganism recovery.

Conclusions
The 3M Environmental Scrub Sampler with 10 mL Wide Spectrum Neutralizer is an effective, stable, robust sampling device for the recovery of Salmonella spp. and Listeria spp.

Highlight
The 3M Environmental Scrub Sampler with 10 mL Wide Spectrum Neutralizer is an acceptable sampling device for use in FDA BAM Salmonella and Listeria reference methods.
Multi-objective equilibrium optimizer: framework and development for solving multi-objective optimization problems
Authors: Premkumar M , Jangir Pradeep , Sowmya R , Alhelou Hassan Haes , Mirjalili Seyedali , Kumar B Santhosh 
Published: October 2021

ABSTRACTThis paper proposes a new Multi-Objective Equilibrium Optimizer (MOEO) to handle complex optimization problems, including real-world engineering design optimization problems. The Equilibrium Optimizer (EO) is a recently reported physics-based metaheuristic algorithm, and it has been inspired by the models used to predict equilibrium state and dynamic state. A similar procedure is utilized in MOEO by combining models in a different target search space. The crowding distance mechanism is employed in the MOEO algorithm to balance exploitation and exploration phases as the search progresses. In addition, a non-dominated sorting strategy is also merged with the MOEO algorithm to preserve the population diversity and it has been considered as a crucial problem in multi-objective metaheuristic algorithms. An archive with an update function is used to uphold and improve the coverage of Pareto with optimal solutions. The performance of MOEO is validated for 33 contextual problems with 6 constrained, 12 unconstrained, and 15 practical constrained engineering design problems, including non-linear problems. The result obtained by the proposed MOEO algorithm is compared with other state-of-the-art multi-objective optimization algorithms. The quantitative and qualitative results indicate that the proposed MOEO provides more competitive outcomes than the different algorithms. From the results obtained for all 33 benchmark optimization problems, the efficiency, robustness, and exploration ability to solve multi-objective problems of the MOEO algorithm are well defined and clarified. The paper is further supported with extra online service and guideline at https://premkumarmanoharan.wixsite.com/mysite.
Japanese Hops (Humulus japonicus) Control and Management Strategies in Large River Floodplains
Authors: Guyon Lyle J , Cosgriff Robert J 
Published: October 2021

AbstractJapanese hops (Humulus japonicus) is an invasive vine that establishes in open areas in riverine habitats and suppresses tree regeneration and native vegetation. This study evaluated the use of herbicides and tree plantings to control and manage Japanese hops on five Mississippi River islands over a four-year period. Herbicide treatments included a preemergent (sulfometuron methyl), a postemergent (glyphosate), and a combination of both. Tree plantings used containerized and bareroot American sycamore (Platanus occidentalis) and eastern cottonwood (Populus deltoides) trees. Japanese hops biomass was significantly lower in all herbicide treatments in 2012 and 2015, but the preemergent treatment was less effective than other treatments in 2012 and 2014. After two years, average survivorship of containerized trees was 20%–42%, whereas bareroot seedlings had near 100% mortality. Results indicate that postemergent treatments are effective for short-term control, but large floods reestablish Japanese hops in treated areas. Reforestation, if combined with herbicide treatments and active management, may be a promising approach in large river floodplains that experience frequent flooding, but low tree survivorship presents challenges to reforestation.
Exploring American Parents’ Lived Experiences During the COVID-19 Pandemic: Ramifications for Well-Being
Authors: Kaugars Astrida S , Holly Lindsay E , Tait Mary , Oswald Debra 
Published: October 2021

Abstract

Objective
The objective of this study was to document the direct impact of the COVID-19 pandemic on parents and families in the United States.

Methods
Parents’ experiences during the pandemic were examined using an online survey (N = 564) collected during May and June 2020.

Results
Parents reported experiencing a high frequency of COVID-19-related events (e.g., job loss and health concerns) and impact on their lives. Parents’ experiences with COVID-19, as well as self-reported perceived increase in home labor, experiences with assisting children with remote schooling, and work-life conflict were all significantly associated with higher levels of parental role overload. COVID-19-related events and impact, as well as parental role overload, significantly predicted parents’ anxiety and depression, even after controlling for demographic factors.

Conclusions
The findings suggest the importance of providing support for parents and families through direct services and public policy changes.
Commission on Human Rights Drafting Committee Second
SessionReport of the Sub-Committee, Consisting of the
Representatives of France, the United Kingdom and the United States
of America, Appointed to Re-Draft Article 13 of the Draft
International Covenant on Human Rights (Document E/600)
Authors: Clooney Amal , Webb Philippa , Nelson Matthew 
Published: October 2021

Abstract
This section presents the Drafting Sub-Committee (CHR) Report, 12 May 1948.