bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 Vaccines Programs: adverse events following immunization (AEFI) among medical Clerkship Student in Jember, Indonesia
Authors: Supangat  , Sakinah Elly Nurus , Nugraha Muhammad Yuda , Qodar Tegar Syaiful , Mulyono Bagus Wahyu , Tohari Achmad Ilham 
Published: October 2021

Abstract
Introduction
Coronavirus Disease (COVID-19) caused by Novel Coronavirus named as Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) was declared Pandemic by The World Health Organization (WHO) and a Public Health Emergency of International Concern (PHEIC) on January 30, 2020. Many COVID-19 vaccines have been developed, including CoronaVac vaccines by Sinovac. Health care workers, along with medical clerkship students are the priority to receive the vaccine. However, the Adverse Events Following Immunization (AEFI) of the CoronaVac remains unclear. This study aims to describe and analyze the adverse events following immunization (AEFI) of COVID-19 vaccination in medical students in clerkship programs.

Method
We conducted a cross-sectional study using a questionnaire to assess AEFI after CoronaVac vaccination among medical clerkship students. A Chi-Square test with 95 % of CI was used to determine whether gender correlated with symptoms of AEFI.

Result
We identified 144 medical clerkship students. The most common AEFI of SARS-CoV-2 vaccinations was localized pain in the injection site during the first dose with 25 (45 %) reports and the booster dose with 34 (67 %) reports. Then followed by malaise, the first dose with 20 (36 %) reports and the booster dose with 21 (41 %) reports. Other symptoms like headache, fever, shivering, sleepiness, nausea, dysphagia, and cold were also reported.

Conclusions
CoronaVac SARS-COV-2 vaccine has several mild symptoms of AEFI and not correlated with gender. Nevertheless, follow-up after vaccination is needed to prevent immunologic responses that may occur in some patients.
Disentangling the symptoms of schizophrenia: Network analysis in acute phase patients and in patients with predominant negative symptoms
Authors: Demyttenaere Koen , Leenaerts Nicolas , Acsai Károly , Sebe Barbara , Laszlovszky István , Barabássy Ágota , Fonticoli Laura , Szatmári Balázs , Earley Willie , Németh György , Correll Christoph U. 
Published: October 2021

AbstractBackgroundThe Positive and Negative Syndrome Scale (PANSS) is widely used in schizophrenia and has been divided into distinct factors (5-factor models) and subfactors. Network analyses are newer in psychiatry and can help to better understand the relationships and interactions between the symptoms of a psychiatric disorder. The aim of this study was threefold: (a) to evaluate connections between schizophrenia symptoms in two populations of patients (patients in the acutely exacerbated phase of schizophrenia and patients with predominant negative symptoms [PNS]), (b) to test whether network analyses support the Mohr 5 factor model of the PANSS and the Kahn 2 factor model of negative symptoms, and finally (c) to identify the most central symptoms in the two populations.MethodsUsing pooled baseline data from four cariprazine clinical trials in patients with acute exacerbation of schizophrenia (n = 2193) and the cariprazine–risperidone study in patients with PNS (n = 460), separate network analyses were performed. Network structures were estimated for all 30 items of the PANSS.ResultsWhile negative symptoms in patients with an acute exacerbation of schizophrenia are correlated with other PANSS symptoms, these negative symptoms are not correlated with other PANSS symptoms in patients with PNS. The Mohr factors were partially reflected in the network analyses. The two most central symptoms (largest node strength) were delusions and uncooperativeness in acute phase patients and hostility and delusions in patients with PNS.ConclusionsThis network analysis suggests that symptoms of schizophrenia are differently structured in acute and PNS patients. While in the former, negative symptoms are mainly secondary, in patients with PNS, they are mainly primary. Further, primary negative symptoms are better conceptualized as distinct negative symptom dimensions of the PANSS.
American Elegy, Reflux
Authors: Mariner Kathryn A. 
Published: October 2021

Abstract
This is a meditation on bad air as a defining bodily, temporal, political, and atmospheric condition of the twenty-first-century American Dream. In 2020, the novel viral respiratory illness COVID-19 stole the final breaths of nearly 350,000 Americans (and severely damaged the lungs of many, many more). George Floyd and Daniel Prude, unarmed and Black, were suffocated by the police in Minneapolis, Minnesota, and Rochester, New York, respectively. Protesters marching in the streets for racial justice were tear-gassed under milky skies. Wildfires raged up and down the West Coast of the United States, thickening the air in the mountains, in the valleys, in the woods, in the cities, with particulate matter. And doctors found a malignant mass in the right lung of this author's mother. This essay uses the double meaning of aspiration (to inhale and to dream) to trace the myriad ways our collective breathing is central to, and curtailed by, the American Aspiration. Grounded through the breath, it traces the deep entanglements of global pandemic, climate change, state violence, and lung cancer, and their combined social, political, and environmental implications for Americans’ collective flourishing, or collective strangulation. Carried on the polar jet stream from rural Oregon, to the streets of Minneapolis and Rochester, to the tobacco plantations of the American South, it is a rhetorical exercise in breathless grief, in having the wind knocked out, in going up in smoke.
Retrospective, Multicenter Analysis Comparing Conventional with Oncoplastic Breast Conserving Surgery: Oncological and Surgical Outcomes in Women with High-Risk Breast Cancer from the OPBC-01/iTOP2 Study
Authors: Fitzal Florian , Bolliger Michael , Dunkler Daniela , Geroldinger Angelika , Gambone Luca , Heil Jörg , Riedel Fabian , de Boniface Jana , Andre Camilla , Matrai Zoltan , Pukancsik Dávid , Paulinelli Regis R. , Ostapenko Valerijus , Burneckis Arvydas , Ostapenko Andrej , Ostapenko Edvin , Meani Francesco , Harder Yves , Bonollo Marta , Alberti Andrea S. M. , Tausch Christoph , Papassotiropoulos Bärbel , Helfgott Ruth , Heck Dietmar , Fehrer Hans-Jörg , Acko Markus , Schrenk Peter , Trapp Elisabeth K. , Gunda Pristauz-Telsnigg , Clara Paliczek , Montagna Giacomo , Ritter Mathilde , Blohmer Jens-Uwe , Steffen Sander , Romics Laszlo , Morrow Elizabeth , Lorenz Katharina , Fehr Mathias , Weber Walter Paul 
Published: October 2021

Abstract
Introduction
Recent data suggest that margins ≥2 mm after breast-conserving surgery may improve local control in invasive breast cancer (BC). By allowing large resection volumes, oncoplastic breast-conserving surgery (OBCII; Clough level II/Tübingen 5-6) may achieve better local control than conventional breast conserving surgery (BCS; Tübingen 1-2) or oncoplastic breast conservation with low resection volumes (OBCI; Clough level I/Tübingen 3-4).

Methods
Data from consecutive high-risk BC patients treated in 15 centers from the Oncoplastic Breast Consortium (OPBC) network, between January 2010 and December 2013, were retrospectively reviewed.

Results
A total of 3,177 women were included, 30% of whom were treated with OBC (OBCI n = 663; OBCII n = 297). The BCS/OBCI group had significantly smaller tumors and smaller resection margins compared with OBCII (pT1: 50% vs. 37%, p = 0.002; proportion with margin <1 mm: 17% vs. 6%, p < 0.001). There were significantly more re-excisions due to R1 (“ink on tumor”) in the BCS/OBCI compared with the OBCII group (11% vs. 7%, p = 0.049). Univariate and multivariable regression analysis adjusted for tumor biology, tumor size, radiotherapy, and systemic treatment demonstrated no differences in local, regional, or distant recurrence-free or overall survival between the two groups.

Conclusions
Large resection volumes in oncoplastic surgery increases the distance from cancer cells to the margin of the specimen and reduces reexcision rates significantly. With OBCII larger tumors are resected with similar local, regional and distant recurrence-free as well as overall survival rates as BCS/OBCI.
In Situ Wrapping of Oriented NaNbO3 with Carbon Nitride to Synergistically Enhance Photoelectrical Utilization at NaNbO3/g-C3N4 Heterostructures
Authors: Fan Baodian , Li Ping , Jiang Linqin , Yang Aijun , Li Jiansheng , Luo Haiyan , Xiong Hao , Lin Lingyan , Qiu Yu 
Published: October 2021

Abstract
Synergetic effects were observed in an oriented-NaNbO3/g-C3N4 heterostructure system synthesized from in situ pyrolysis of urea with hydrothermally prepared NaNbO3 microcuboids. Chemically wrapping NaNbO3 with an appropriate amount of g-C3N4 forms an efficient heterojunction which separates photoexcited charges, and the internal electric field produced by oriented NaNbO3 grains facilitates their transfer. The mechanism developed here is applicable to enhancing photoelectrical utilization in other perovskite systems.
Η αποτελεσματικότητα του εκπαιδευτικού στο πλαίσιο μιας εκπαίδευσης χωρίς αποκλεισμούς
Authors: Καραγιάννη Ελένη 
Published: October 2021

Ως αποτελεσματικότητα του εκπαιδευτικού θεωρείται η πεποίθηση στην ικανότητά του να οργανώνει και να εκτελεί τις απαιτούμενες ενέργειες για την επίτευξη συγκεκριμένων εκπαιδευτικών στόχων, συμβάλλοντας ουσιαστικά στην παραγωγή προσδοκώμενων αποτελεσμάτων. Επιπλέον, τα τελευταία χρόνια, στο πλαίσιο της κοινωνικής δικαιοσύνης, προβάλλει πάγιο το αίτημα για την παροχή ίσων ευκαιριών ποιοτικής εκπαίδευσης για όλους τους μαθητές. Σκοπός της έρευνας είναι να εξετάσει τα χαρακτηριστικά των εκπαιδευτικών με υψηλή αίσθηση αποτελεσματικότητας και τις συνέπειές της για τους ίδιους και για τον ποικιλόμορφο μαθητικό πληθυσμό της τάξης τους. Τα ευρήματα έδειξαν ότι υφίστανται ισχυρές αλληλεπιδράσεις μεταξύ των θετικών πεποιθήσεων τους για την παροχή μιας εκπαίδευσης χωρίς αποκλεισμούς, των εκπαιδευτικών στρατηγικών που επιλέγουν και των μαθησιακών επιτευγμάτων. Συμπερασματικά προκύπτει ότι οι εκπαιδευτικοί, που καθοδηγούν ως μέντορες τους μαθητές τους στη ενεργή οικοδόμηση της γνώσης, αναγνωρίζοντας την ευθύνη τους και ικανοποιώντας διαφορετικές ανάγκες, επιτυγχάνουν υψηλούς δείκτες ακαδημαϊκής επίτευξης και συναισθηματικής ανάπτυξης για το σύνολο των ετερογενών μαθητών τους.
To βιολογικό ρολόι των μαθητών/τριών και η σχέση του με την φοίτηση. Η επίδραση του ύπνου και οι απόψεις των μαθητών/τριών Δευτεροβάθμιας Εκπαίδευσης
Authors: Νοτοπούλου Βασιλική 
Published: October 2021

Είναι γεγονός ότι το βιολογικό ρολόι και γενικότερα οι βιορυθμοί καθορίζουν σε μεγάλο βαθμό την καθημερινότητα των μαθητών και τις μαθησιακές τους διαδικασίες. Η παρούσα εργασία είχε ως στόχο να διερευνήσει τις απόψεις των μαθητών για το χρόνο τους, καθώς και το πώς συνδέεται ο χρόνος με τη σχολική φοίτηση, αλλά και τα συναισθήματα που βιώνουν κατά τη συμμετοχή τους στο σχολικό πρόγραμμα και σε εξωσχολικές δραστηριότητες. Το δείγμα της έρευνας αποτελείται από μαθητές που φοιτούσαν σε σχολεία της Δευτεροβάθμιας Εκπαίδευσης του Νομού Κοζάνης (n=252 μαθητές). Για την συλλογή των δεδομένων επιλέχθηκε ως εργαλείο ένα έντυπο δομημένο ερωτηματολόγιο με 22 ερωτήσεις. Τα αποτελέσματα που προέκυψαν από την έρευνα, οδηγούν στη διαπίστωση ότι για την πιο αποτελεσματική διαχείριση του σχολικού χρόνου θα πρέπει να λαμβάνεται υπόψη η κυρίαρχη σημασία των βιορυθμών στην διδακτική πράξη και στην εκπαιδευτική πραγματικότητα. Είναι επίσης σημαντική η βαρύτητα στη διάρκεια του ύπνου καθώς και στη ποιότητά του, επειδή αποτελεί σημαντικό δείκτη της απόδοσής τους.
Characteristics of new patient referrals to specialised diabetic foot units across Europe and factors influencing delays
Authors: Bouillet Benjamin , Ahluwalia Raju , Iacopi Elisabetta , Garcia-Klepzig José Luis , Lüdemann Claas , Manu Chris , Meloni Marco , Saenz De Buruaga Víctor Rodriguez , Vouillarmet Julien , Petit Jean-Michel , Van Acker Kristien , Lázaro-Martínez José Luis 
Published: October 2021

Objective: Foot ulcers are a common complication of diabetes and are associated with an increase in lower limb amputation and death. Early referral to a specialised unit is recommended. The aim of this study was to assess the characteristics of new-patient referrals to specialised diabetes foot care units across Europe and to determine the factors involved in delayed referral. Method: In this prospective observational study, consecutive patients with a new foot ulcer presenting to nine diabetic foot centres in five European countries (France, Germany, Italy, Spain and the UK) were included. Results: Some 25% of the 332 patients included had presented with a foot ulcer >3 months before referral to the participating foot clinic. Compared with patients referred earlier, patients with a long time to referral (>3 months) were older (p=0.006) and had a less severe wound according to Infectious Diseases Society of America (IDSA) classification (p=0.003) and University of Texas classification (grade D=infection + peripheral artery disease, p=0.004). Conclusion: The proportion of patients with a diabetic foot ulcer (DFU) referred to a specialised unit >3 months after the beginning of the ulcer remained high throughout Europe. Patients with severe DFU were, however, referred more quickly by front line health professionals. Primary care professionals need to be made aware of the importance of early referral to a specialised unit in order to improve the management of foot disease in patients with diabetes. Declaration of interest: The authors have no conflicts of interest to declare.
Chronic wounds in Sierra Leone: Searching for Buruli ulcer, a NTD caused by Mycobacterium ulcerans, at Masanga Hospital
Authors: Please Helen R. , Vas Nunes Jonathan H. , Patel Rashida , Pluschke Gerd , Tholley Mohamed , Ruf Marie-Therésè , Bolton William , Scott Julian A. , Grobusch Martin P. , Bolkan Håkon A. , Brown Julia M. , Jayne David G. 
Published: October 2021

Background
Chronic wounds pose a significant healthcare burden in low- and middle-income countries. Buruli ulcer (BU), caused by Mycobacterium ulcerans infection, causes wounds with high morbidity and financial burden. Although highly endemic in West and Central Africa, the presence of BU in Sierra Leone is not well described. This study aimed to confirm or exclude BU in suspected cases of chronic wounds presenting to Masanga Hospital, Sierra Leone.

Methodology
Demographics, baseline clinical data, and quality of life scores were collected from patients with wounds suspected to be BU. Wound tissue samples were acquired and transported to the Swiss Tropical and Public Health Institute, Switzerland, for analysis to detect Mycobacterium ulcerans using qPCR, microscopic smear examination, and histopathology, as per World Health Organization (WHO) recommendations.

Findings
Twenty-one participants with wounds suspected to be BU were enrolled over 4-weeks (Feb-March 2019). Participants were predominantly young working males (62% male, 38% female, mean 35yrs, 90% employed in an occupation or as a student) with large, single, ulcerating wounds (mean diameter 9.4cm, 86% single wound) exclusively of the lower limbs (60% foot, 40% lower leg) present for a mean 15 months. The majority reported frequent exposure to water outdoors (76%). Self-reports of over-the-counter antibiotic use prior to presentation was high (81%), as was history of trauma (38%) and surgical interventions prior to enrolment (48%). Regarding laboratory investigation, all samples were negative for BU by microscopy, histopathology, and qPCR. Histopathology analysis revealed heavy bacterial load in many of the samples. The study had excellent participant recruitment, however follow-up proved difficult.

Conclusions
BU was not confirmed as a cause of chronic ulceration in our cohort of suspected cases, as judged by laboratory analysis according to WHO standards. This does not exclude the presence of BU in the region, and the definitive cause of these treatment-resistance chronic wounds is uncertain.
Multivessel versus IRA-only PCI in patients with NSTEMI and severe left ventricular systolic dysfunction
Authors: Lee Myunhee , Kim Dae-Won , Park Mahn-Won , Lee Kyusup , Her Sung-Ho , Chang Kiyuk , Chung Wook Sung , Jeong Myung Ho , Rha Seung-Woon , Kim Hyo-Soo , Gwon Hyeon Cheol , Seong In Whan , Hwang Kyung Kuk , Chae Shung Chull , Kim Kwon-Bae , Kim Young Jo , Cha Kwang Soo , Oh Seok Kyu , Chae Jei Keon , Jung Ji-Hoon ,   on behalf of KAMIR-NIH registry investigators
Published: October 2021

BackgroundA substantial number of patients presenting with non-ST-elevation myocardial infarction (NSTEMI) and multivessel disease (MVD) have severe left ventricular systolic dysfunction (LVSD) (left ventricular ejection fraction (LVEF) less than 35%). But data are lacking regarding optimal percutaneous coronary intervention (PCI) strategy for these patients. The aim of this study was to compare the long-term outcomes of IRA (infarct-related artery)-only and multivessel PCI in patients with NSTEMI and MVD complicated by severe LVSD.MethodsAmong 13,104 patients enrolled in the PCI registry from November 2011 to December 2015, patients with NSTEMI and MVD with severe LVSD who underwent successful PCI were screened. The primary outcome was 3-year major adverse cardiovascular events (MACEs), defined as all-cause death, any myocardial infarction, stroke, and any revascularization.ResultsOverall, 228 patients were treated with IRA-only PCI (n = 104) or MV-PCI (n = 124). The MACE risk was significantly lower in the MV-PCI group than in the IRA-only PCI group (35.5% vs. 54.8%; hazard ratio [HR] 0.561; 95% confidence interval [CI] 0.378–0.832; p = 0.04). This result was mainly driven by a significantly lower risk of all-cause death (23.4% vs. 41.4%; hazard ratio [HR] 0.503; 95% confidence interval [CI] 0.314–0.806; p = 0.004). The results were consistent after multivariate regression, propensity-score matching, and inverse probability weighting to adjust for baseline differences.ConclusionsAmong patients with NSTEMI and MVD complicated with severe LVSD, multivessel PCI was associated with a significantly lower MACE risk. The findings may provide valuable information to physicians who are involved in decision-making for these patients.
Durability of Integrase STrand Inhibitor (InSTI)-based regimen in geriatric people living with HIV in the GEPPO cohort
Authors: Focà Emanuele , Calcagno Andrea , Calza Stefano , Renzetti Stefano , Chiesa Annacarla , Siano Matteo , De Socio Giuseppe , Piconi Stefania , Orofino Giancarlo , Madeddu Giordano , Cattelan Anna Maria , Nozza Silvia , Ferrara Micol , Milic Jovana , Celesia Benedetto Maurizio , Castelli Francesco , Guaraldi Giovanni 
Published: October 2021

Objective
To investigate the durability of the first integrase inhibitor-based regimen in a HIV geriatric multicentric prospective cohort and to explore the reasons of regimen discontinuation.

Design
This is an analysis conducted on the Geriatric Patients Living with HIV/AIDS (GEPPO) cohort, an Italian prospective observational multicentre cohort of people living with HIV with 65 years of age or more.

Methods
The analysis was performed using R (version 4.0.2). The tests performed were two sided assuming a 5% significance level (Kruskal-Wallis test, Chi-squared test, log-rank test and a Cox Proportional Hazard model). The proportion of participants discontinuing the three regimens was displayed using cumulative curves.

Results
Among 1531 patients enrolled between 2017 and 2019 in the GEPPO cohort, we included 822 participants in this analysis. At baseline, median age was 69.8, the immunovirological profile good, multimorbidity was present in 42.3% of participants, while 27.4% were on polypharmacy. Overall, 483, 243 and 96 participants received DTG, RAL and EVG/c respectively as first InSTI. At the end of the follow up 6.4%, 21.1% and 22.9% participants discontinued DTG, RAL and EVG/c respectively. Using a log-rank test, EVG showed a significantly lower durability than DTG (p<0.001) or RAL (p 0.05) or both, DTG and RAL (p<0.001). Among participants who discontinued their regimen we found 0 virological failure and 56.7% simplification/deprescription.

Conclusions
The three integrase inhibitors considered showed a good durability and no virological failures in geriatric patients such as those enrolled in the GEPPO cohort when used in a two or three drug regimen.
A novel insertion design of fiber materials for the adhesive reattachment in vertically fractured teeth
Authors: Kurnaz Safa , Keçeci Ayşe Diljin 
Published: October 2021

ObjectiveThisex vivostudy aimed to evaluate the strengthening effect of different ferrule and reattachment designs with fiber and adhesive materials on vertically fractured teeth.MethodsNinety extracted single-root premolars were instrumented and divided into nine groups (two control groups and seven experimental groups; n = 10). The negative control (NC) group comprised of intact teeth, while the positive control (PC) group comprised of root canal-treated teeth. The roots of the teeth in the experimental groups were vertically fractured into two equal fragments. The fragments were reattached with one of the followings: 4-methacryloxyethyl trimellitate anhydride/methacrylate-tri-n-butyl borane (4-META/MMA-TBB) resin, 4-META/MMA-TBB + quartz fiber post, 4-META/MMA-TBB + glass fiber bundles, 4-META/MMA-TBB + quartz fiber post + 1 mm ferrule, 4-META/MMA-TBB + glass fiber bundles + 1 mm ferrule, 4-META/MMA-TBB + quartz fiber post + 2 mm ferrule, and 4-META/MMA-TBB + glass fiber bundles + 2 mm ferrule. The core build-ups were made with composite resin. The specimens were subjected to compressive loading until failure occurred. Mean load necessary to fracture each sample and the fracture types of these samples were recorded.ResultsThe highest mean fracture load was recorded in the NC group (1,036.7 N), which was not significantly higher than the PC group (989.66 N) (p > 0.05). The roots reattached with quartz fiber post demonstrated significantly less fracture strength (871.9 N) as compared to the other test and control groups (p < 0.05). There was no significant difference between the PC group and reattached fragments with different ferrule designs in terms of fracture resistance (p > 0.05).ConclusionsThe customized fiber bundles may be more suitable for reattachment of vertically fractured teeth than the rigid fiber posts. For reattachment procedures, the ferrule design may be preferred to increase the fracture strength of vertically fractured teeth.
Exploration, Isolation, and Identification of Carotenoid from Bacterial Symbiont of Sponge Callyspongia vaginalis
Authors: Abfa Iqna Kamila , Radjasa Ocky Karna , Susanto A B , Nuryadi Handung , Karwur Ferry F. 
Published: October 2021

During the past two decades research on marine bacteria has highlighted the tremendous potential of symbiotic-microorganisms as a source of bioactive secondary. One of the potential of the bacterial symbionts is producing a natural pigment, and these organisms can be used as a sustainable source of natural pigments. Carotenoid is one of the most important pigments that has important roles in physiological and molecular processes of microorganisms, as well as for human health. The objective of this study is to analyze carotenoid pigments from marine bacterial symbionts from sponge and to identify bacterial symbionts that produce carotenoid pigments. Pigment analysis was performed by a UV-VIS spectrophotometer and High Performance Liquid Chromatography (HPLC). Molecular bacterial identification was performed based on 16S rDNA sequence. The isolation of bacterial symbionts from C. vaginalison Zobell 2216E medium resulted in one bacterium, CB-SP5, positively synthesized carotenoids. By reverse phase HPLC analysis, the carotenoid pigments in the bacterial symbionts were identified as diadinoxanthin, fucoxanthin, neoxanthin, dinoxanthin, anddiadinochrome. CB-SP5 shared the highest level of 16S rDNA gene sequence similarity with Psychrobacter celer (99%). Keywords : carotenoid, sponge, bacterial symbiont, 16S rDNA.