bluuebunny/crossref_metadata_2025_split huggingface dataset:
Markers for the involvement of endothelial cells and the coagulation system in chronic urticaria: A systematic review
Authors: Mostmans Yora , De Smedt Katleen , Richert Bertrand , Elieh Ali Komi Daniel , Maurer Marcus , Michel Olivier 
Published: March 2021

AbstractChronic urticaria (CU) is a chronic inflammatory mast cell‐driven disorder. Endothelial cells (ECs) contribute importantly to key features of CU. Several markers of EC (dys)function in CU have been reported, but have not yet been systematically reviewed. In this study, we systematically reviewed and categorized all published markers of EC functions in CU through a comprehensive search in Pubmed, The Cochrane Library, Web of Science, and SCOPUS using the following Mesh terms: CU AND pathogenesis AND (vasculopathy OR microangiopathy OR ECs OR marker). In total, 79 articles were selected and the identified biomarkers were categorized according to EC (dys)function in CU. The most frequent and consistently reported upregulated biomarkers in CU skin were adhesion molecules, TF, and P‐selectin. The most frequently reported upregulated and reliable biomarkers in sera of CU patients were F1+2 for coagulation cascade involvement, D‐dimers for fibrinolysis, and MMP‐9 for vascular permeability. Emerging biomarkers described in the selected articles were endostatin, heat shock proteins, cleaved high molecular weight kininogen, and adipokines. This systematic review contributes to the pool of growing evidence for vascular involvement in CU where EC dysfunction is present in different aspects of cell survival, maintenance of vascular structure, and coagulation/fibrinolysis balance.
Efficacy and safety of oral misoprostol vs transvaginal balloon catheter for labor induction: An observational study within the SWEdish Postterm Induction Study (SWEPIS)
Authors: Alkmark Mårten , Carlsson Ylva , Wendel Sophia Brismar , Elden Helen , Fadl Helena , Jonsson Maria , Ladfors Lars , Saltvedt Sissel , Sengpiel Verena , Wessberg Anna , Wikström Anna‐Karin , Hagberg Henrik , Wennerholm Ulla‐Britt 
Published: March 2021

AbstractIntroductionInduction of labor is increasing. A common indication for induction of labor is late term and postterm pregnancy at 41 weeks or more. We aimed to evaluate if there are any differences regarding efficacy, safety, and women's childbirth experience between oral misoprostol and transvaginal balloon catheter for cervical ripening in women with a low‐risk singleton pregnancy and induction of labor at 41+0 to 42+0 to 1 weeks of gestation.Material and methodsIn this observational study, based on data from the Swedish Postterm Induction Study (SWEPIS), a multicenter randomized controlled trial, a total of 1213 women with a low‐risk singleton pregnancy at 41 to 42 weeks of gestation were induced with oral misoprostol (n = 744) or transvaginal balloon catheter (n = 469) at 15 Swedish delivery hospitals. The primary efficacy outcome was vaginal delivery within 24 h and primary safety outcomes were neonatal and maternal composite adverse outcomes. Secondary outcomes included time to vaginal delivery and mode of delivery. Women's childbirth experience was assessed with the Childbirth Experience Questionnaire (CEQ 2.0) and visual analog scale. We present crude and adjusted mean differences and relative risks (RR) with 95% CI. Adjustment was performed for a propensity score based on delivery hospital and baseline characteristics including Bishop score.ResultsVaginal delivery within 24 h was significantly lower in the misoprostol group compared with the balloon catheter group (46.5% [346/744] vs 62.7% [294/469]; adjusted RR 0.76 95% CI 0.640.89]). Primary neonatal and maternal safety outcomes did not differ between groups (neonatal composite 3.5% [36/744] vs 3.2% [15/469]; adjusted RR 0.77 [95% CI 0.31–1.89]; maternal composite 2.3% [17/744] vs 1.9% [9/469]; adjusted RR 1.70 [95% CI 0.58–4.97]). Adjusted mean time to vaginal delivery was increased by 3.8 h (95% CI 1.3–6.2 h) in the misoprostol group. Non‐operative vaginal delivery and cesarean delivery rates did not differ. Women's childbirth experience was positive overall and similar in both groups.ConclusionsInduction of labor with oral misoprostol compared with a transvaginal balloon catheter was associated with a lower probability of vaginal delivery within 24 h and a longer time to vaginal delivery. However, primary safety outcomes, non‐operative vaginal delivery, and women's childbirth experience were similar in both groups. Therefore, both methods can be recommended in women with low‐risk postdate pregnancies.
Connections matter: Institutionalization of LDP's relations with the CCP
Authors: Zakowski Karol 
Published: March 2021

AbstractSince the beginning of the 1990s, the Liberal Democratic Party (LDP) of Japan has tried to institutionalize contacts with the Chinese Communist Party (CCP). Until 2009, the Sino‐Japanese Conference of Exchange Between the Ruling Parties did little to build ties of trust between both sides, but its revival in 2015 proved much more successful. This article argues that as the institutionalized channels were prone to disturbance caused by ideological leanings of party officials, they did not work as efficiently as sub‐party level of exchange. The weakening of LDP factions and centralization of decision‐making process under the Prime Minister, however, contributed to shortages of Japan's semi‐official diplomacy towards China, which detrimentally influenced bilateral contacts, especially under the second Abe administration. Paradoxically, since 2015 the revived Conference started playing a more important role thanks to determination of LDP secretaries‐general. This article examines the gravity of these personal factors in LDP–CCP relations.
Functional brain imaging in larval zebrafish for characterising the effects of seizurogenic compounds acting via a range of pharmacological mechanisms
Authors: Winter Matthew J. , Pinion Joseph , Tochwin Anna , Takesono Aya , Ball Jonathan S. , Grabowski Piotr , Metz Jeremy , Trznadel Maciej , Tse Karen , Redfern Will S. , Hetheridge Malcolm J. , Goodfellow Marc , Randall Andrew D. , Tyler Charles R. 
Published: March 2021

Background and PurposeFunctional brain imaging using genetically encoded Ca2+ sensors in larval zebrafish is being developed for studying seizures and epilepsy as a more ethical alternative to rodent models. Despite this, few data have been generated on pharmacological mechanisms of action other than GABAA antagonism. Assessing larval responsiveness across multiple mechanisms is vital to test the translational power of this approach, as well as assessing its validity for detecting unwanted drug‐induced seizures and testing antiepileptic drug efficacy.Experimental ApproachUsing light‐sheet imaging, we systematically analysed the responsiveness of 4 days post fertilisation (dpf; which are not considered protected under European animal experiment legislation) transgenic larval zebrafish to treatment with 57 compounds spanning more than 12 drug classes with a link to seizure generation in mammals, alongside eight compounds with no such link.Key ResultsWe show 4dpf zebrafish are responsive to a wide range of mechanisms implicated in seizure generation, with cerebellar circuitry activated regardless of the initiating pharmacology. Analysis of functional connectivity revealed compounds targeting cholinergic and monoaminergic reuptake, in particular, showed phenotypic consistency broadly mapping onto what is known about neurotransmitter‐specific circuitry in the larval zebrafish brain. Many seizure‐associated compounds also exhibited altered whole brain functional connectivity compared with controls.Conclusions and ImplicationsThis work represents a significant step forward in understanding the translational power of 4dpf larval zebrafish for use in neuropharmacological studies and for studying the events driving transition from small‐scale pharmacological activation of local circuits, to the large network‐wide abnormal synchronous activity associated with seizures.
Cellular models of development of ovarian high‐grade serous carcinoma: A review of cell of origin and mechanisms of carcinogenesis
Authors: Mei Jie , Tian Huixiang , Huang Hsuan‐Shun , Hsu Che‐Fang , Liou Yuligh , Wu Nayiyuan , Zhang Wei , Chu Tang‐Yuan 
Published: March 2021

AbstractHigh‐grade serous carcinoma (HGSC) is the most common and malignant histological type of epithelial ovarian cancer, the origin of which remains controversial. Currently, the secretory epithelial cells of the fallopian tube are regarded as the main origin and the ovarian surface epithelial cells as a minor origin. In tubal epithelium, these cells acquire TP53 mutations and expand to a morphologically normal ‘p53 signature’ lesion, transform to serous tubal intraepithelial carcinoma and metastasize to the ovaries and peritoneum where they develop into HGSC. This shifting paradigm of the main cell of origin has revolutionarily changed the focus of HGSC research. Various cell lines have been derived from the two cellular origins by acquiring immortalization via overexpression of hTERT plus disruption of TP53 and the CDK4/RB pathway. Malignant transformation was achieved by adding canonical driver mutations (such as gain of CCNE1) revealed by The Cancer Genome Atlas or by noncanonical gain of YAP and miR181a. Alternatively, because of the extreme chromosomal instability, spontaneous transformation can be achieved by long passage of murine immortalized cells, whereas in humans, it requires ovulatory follicular fluid, containing regenerating growth factors to facilitate spontaneous transformation. These artificially and spontaneously transformed cell systems in both humans and mice have been widely used to discover carcinogens, oncogenic pathways and malignant behaviours in the development of HGSC. Here, we review the origin, aetiology and carcinogenic mechanism of HGSC and comprehensively summarize the cell models used to study this fatal cancer having multiple cells of origin and overt genomic instability.
Structured diagnostic assessment of hand eczema in cleaning workers
Authors: Jamiolkowski Dagmar , Steveling‐Klein Esther , Thomas Zita‐Rose Manjaly , Bircher Andreas , Hofmeier Kathrin Scherer , Hartmann Karin 
Published: March 2021

SummaryHand dermatitis is a widespread problem among cleaners. In most cases, it is caused by a combination of wet work and contact with irritants, which can result in irritant (toxic) contact dermatitis. In some cases, the irritant contact eczema then evolves into allergic contact dermatitis, although not all cases of allergic contact dermatitis are preceded by irritant contact dermatitis. This mini‐review proposes a two‐step diagnostic algorithm based on patch testing, which can be used if allergic contact dermatitis is suspected in cleaning workers. As a first step, we recommend performing the DKG standard series (German Contact allergy research group, DKG), the DKG rubber series, both DKG “further fragrances” series as well as the DKG preservative and disinfectant series. If there are clear hints of an occupational contact dermatitis, the first step can also involve testing patients’ own products alongside the standardized tests. In a second step (at the latest), if standardized tests do not suffice to identify the culprit allergen and there is well‐founded suspicion, we recommend testing the patients’ own products. If necessary, the second step can also include testing the individual contact allergens contained in the screening mixes that are part of the standard series.
Intra‐active refractions
Authors: Pryor Adam 
Published: March 2021

AbstractResponding to the analyses that Andreas Losch and Lucas John Mix offer regarding Living with Tiny Aliens: The Image of God for the Anthropocene, this article begins to address how their respective concerns regarding ratiocentric and anthropocentric ideas haunt the construction of a planetary account of the imago Dei. The article then introduces a subsequent line of critique not mentioned by Losch or Mix related to decentering the human individual from accounts of the imago Dei in order to highlight an ongoing challenge for transdisciplinary theological projects that involve astrobiology.
Quality of life measures in pediatric multiple sclerosis: a systematic review and meta‐analysis
Authors: Ow Nikki , Mozafarinia Maryam , Mayo Nancy E 
Published: March 2021

AimTo identify generic measures used to measure quality of life (QoL) in pediatric multiple sclerosis research, estimate an overall score of children and adolescents with pediatric multiple sclerosis, and compare the scores to scores of typically developing children and adolescents.MethodA systematic search was conducted on four databases. All studies were included if: the sample was children with pediatric demyelinating disorders; self‐reported QoL/health‐related quality of life (HRQoL) measures or results were reported; and the mean age of the sample was below 21 years. Quality of the included articles was appraised using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist and the Mixed Methods Appraisal Tool checklist. A meta‐analysis was also conducted.ResultsA total of 12 full‐text articles were included. Content analysis showed that many components of QoL were not included in the measures. Seven studies were included in the meta‐analysis. The meta‐analyzed score was 75.7 (95% confidence interval 71.2–80.3) with a pooled standard deviation of 16.6. Scores of typically developing children and children with pediatric multiple sclerosis were similar.InterpretationMost measures assessed HRQoL and not QoL. Development of a condition‐specific measure of QoL for children and adolescents with pediatric multiple sclerosis would make an important contribution to the field.
What this paper adds

Health‐related quality of life (HRQoL) measures were used to measure quality of life in pediatric multiple sclerosis.

HRQoL scores in pediatric multiple sclerosis were similar to typically developing children and adolescents.
Henagliflozin as add‐on therapy to metformin in patients with type 2 diabetes inadequately controlled with metformin: A multicentre, randomized, double‐blind, placebo‐controlled, phase 3 trial
Authors: Weng Jianping , Zeng Longyi , Zhang Yuwei , Qu Shen , Wang Xueying , Li Ping , Fu Liujun , Ma Boqing , Ye Shandong , Sun Jiao , Lu Weiping , Liu Zhiwen , Chen Daoxiong , Cheng Zhifeng , Liu Haiyan , Zhang Tao , Zou Jianjun 
Published: March 2021

AbstractAimTo evaluate the efficacy and safety of henagliflozin in patients with type 2 diabetes mellitus (T2DM) inadequately controlled with metformin.Material and MethodsThis multicentre phase 3 trial included a 24‐week randomized, double‐blind, placebo‐controlled period, followed by a 28‐week extension period. Patients with a glycated haemoglobin (HbA1c) level of 7.0% (53 mmol/mol) to 10.5% (91 mmol/mol) were randomized and treated with once‐daily placebo (n = 161), henagliflozin 5 mg (n = 162), or henagliflozin 10 mg (n = 160). After 24 weeks, patients on placebo were switched to 5 mg or 10 mg henagliflozin for the additional 28‐week treatment, and patients on henagliflozin during 24‐week treatment period maintained this initial therapy. The primary endpoint was change in HbA1c from baseline to Week 24.ResultsAt Week 24, the least squares mean HbA1c changes versus placebo from baseline were − 0.76% (−8.3 mmol/mol) and − 0.80% (−8.7 mmol/mol) for henagliflozin 5 and 10 mg, respectively (all P < 0.0001). Compared with the placebo group, both doses of henagliflozin lowered fasting plasma glucose, 2‐hour postprandial plasma glucose, body weight and blood pressure, and increased the proportions of patients achieving HbA1c <7.0% (53 mmol/mol) at Week 24. The trends in these improvements were sustained over an additional 28 weeks. Slightly higher proportions of ketosis and presence of urine ketone bodies were observed in patients treated with henagliflozin compared to placebo at Week 24. No diabetic ketoacidosis or episodes of severe hypoglycaemia were reported.ConclusionsHenagliflozin 5 mg or 10 mg as add‐on therapy to metformin provided a new therapeutic option for the treatment of T2DM patients who have inadequate glycaemic control with metformin alone, and was generally well tolerated.
Foul‐weather friends: Modelling thermal stress mitigation by symbiotic endolithic microbes in a changing environment
Authors: Zardi Gerardo I. , Monsinjon Jonathan R. , McQuaid Christopher D. , Seuront Laurent , Orostica Mauricio , Want Andrew , Firth Louise B. , Nicastro Katy R. 
Published: March 2021

ABSTRACTTemperature extremes are predicted to intensify with climate change. These extremes are rapidly emerging as a powerful driver of species distributional changes with the capacity to disrupt the functioning and provision of services of entire ecosystems, particularly when they challenge ecosystem engineers. The subsequent search for a robust framework to forecast the consequences of these changes mostly ignores within‐species variation in thermal sensitivity. Such variation can be intrinsic, but can also reflect species interactions. Intertidal mussels are important ecosystem engineers that host symbiotic endoliths in their shells. These endoliths unexpectedly act as conditionally beneficial parasites that enhance the host's resistance to intense heat stress. To understand how this relationship may be altered under environmental change, we examined the conditions under which it becomes advantageous by reducing body temperature. We deployed biomimetic sensors (robomussels), built using shells of mussels (Mytilus galloprovincialis) that were or were not infested by endoliths, at nine European locations spanning a temperature gradient across 22°of latitude (Orkney, Scotland to the Algarve, Portugal). Daily wind speed and solar radiation explained the maximum variation in the difference in temperature between infested and non‐infested robomussels; the largest difference occurred under low wind speed and high solar radiation. From the robomussel data, we inferred body temperature differences between infested and non‐infested mussels during known heatwaves that induced mass mortality of the mussel Mytilus edulis along the coast of the English Channel in summer 2018 to quantify the thermal advantage of endolith infestation during temperature extremes. Under these conditions, endoliths provided thermal buffering of between 1.7°C and 4.8°C. Our results strongly suggest that sustainability of intertidal mussel beds will increasingly depend on the thermal buffering provided by endoliths. More generally, this work shows that biomimetic models indicate that within‐species thermal sensitivity to global warming can be modulated by species interactions, using an intertidal host–symbiont relationship as an example.
A two‐week single‐group longitudinal test of a new sonic‐powered toothbrush simulating the ‘bass brushing technique’ with tapered bristles on the brush head for reduction of dental plaque and gingivitis
Authors: Su Qing‐qing , Pang Liang‐yue , Zhou Yang , Yu Li‐xia , Lin Huan‐cai , Zhi Qing‐hui 
Published: March 2021

AbstractObjectiveTo investigate the effect of a new powered toothbrush with tapered bristles on the brush head for the reduction of dental plaque and gingivitis.MethodsThis was a single‐centre, single‐group, longitudinal clinical trial. Thirty‐two participants who were typical manual toothbrush users were recruited and assigned the sonic‐powered brush. Interviews were arranged on the 1st, 4th, and 15th days which represented the baseline (T1), middle (T2) and final (T3) time points, respectively. At each visit, the plaque index (PlI), gingival index (GI), bleeding on probing (BOP) and probing depth (PD) were recorded for the Ramfjord index teeth, gingival crevicular fluid(GCF) samples were collected and the proportions of eight periodontal pathogenic bacteria were analysed. Repeated‐measures analysis of variance (ANOVA) was used for comparisons at different time points.ResultsPlI was significantly reduced by 41.67% from T1 to T2 (p<0.001) and decreased by 18.57% from T2 to T3 (p=0.003). GI also varied significantly from T1 to T2 (p=0.018) and T1 to T3 (p=0.037). A 35.86% reduction in the BOP percentage occurred after using the sonic‐powered toothbrush for 3 days (p=0.001). However, no significant difference was observed in the mean values of PD at different examination intervals (p=0.529). There was no significant difference in the proportions of bacteria between T1 and T3 (p>0.05).ConclusionThis research demonstrated the efficacy of the sonic‐powered brush handle together with tapered bristles on the brush in reducing plaque and gingivitis within a short time period.
The procedural and interpersonal justice of automated application and resume screening
Authors: Noble Sean M. , Foster Lori L. , Craig S. Bartholomew 
Published: March 2021

AbstractResearch on organizational justice theory has yet to fully explore how automated application and resume screening procedures affect justice perceptions. In a 2 × 3 experimental design, MTurk workers (N = 360) were randomly assigned to read one of six vignettes describing a job application scenario of either a traditionally administered or algorithmically administered screening procedure with an outcome favorability of acceptance, rejection, or unknown. They then rated procedural and interpersonal justice across eight dimensions. A MANOVA and follow‐up univariate ANOVAs indicated that automated screening was rated lower on job relatedness‐predictive, job relatedness‐content, opportunity to perform, reconsideration opportunity, treatment, two‐way communication, and propriety of questions, and higher on consistency. The interaction between screening procedure and outcome favorability showed mixed results.
MiR‐155 promotes colitis‐associated intestinal fibrosis by targeting HBP1/Wnt/β‐catenin signalling pathway
Authors: Li Nianshuang , Ouyang Yaobin , Xu Xinbo , Yuan Zhenxiang , Liu Chunquan , Zhu Zhenhua 
Published: March 2021

AbstractIntestinal fibrosis is the most common complication of Crohn's disease (CD) that is one major disorder of inflammatory bowel disease (IBD), but the precise mechanism remains unclear. MiR‐155 has been involved in fibrotic diseases. Here, we determined the role of miR‐155 in regulating intestinal fibrosis. MiR‐155 levels were significantly up‐regulated in CD patients with intestinal stricture CD. The overexpression of miR‐155 significantly aggravated TNBS‐induced CD‐associated intestinal fibrosis. Mechanistically, we identified that HBP1, a negative regulator of the Wnt/β‐catenin signalling pathway, is a direct target of miR‐155. Moreover, in vitro and in vivo experiments suggested that the miR‐155/HBP1 axis activates Wnt/β‐catenin signalling pathway to induce intestinal fibrosis. Taken together, we demonstrated that miR‐155 directly targets HBP1 to induce CD‐associated intestinal fibrosis via Wnt/β‐catenin signalling pathway.