bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subacute Inhalation of Ultrafine Particulate Matter Triggers Inflammation Without Altering Amyloid Beta Load in 5xFAD mice
Authors: Saveleva Liudmila , Vartiainen Petra , Gorova Veronika , Chew Sweelin , Belaya Irina , Konttinen Henna , Zucchelli Martina , Korhonen Paula , Kaartinen Emma , Kortelainen Miika , Lamberg Heikki , Sippula Olli , Malm Tarja , Jalava Pasi I , Kanninen Katja M 
Published: September 2021

ABSTRACTEpidemiological studies reveal that air pollution exposure may exacerbate neurodegeneration. Ultrafine particles (UFPs) are pollutants that remain unregulated in ambient air by environmental agencies. Due to their small size (<100nm), UFPs have the most potential to cross the bodily barriers and thus impact the brain. However, little information exists about how UFPs affect brain function. Alzheimer’s disease (AD) is the most common form of dementia, which has been linked to air pollutant exposure, yet limited information is available on the mechanistic connection between them. This study aims to decipher the effects of UFPs in the brain and periphery using the 5xFAD mouse model of AD. In our study design, AD mice and their wildtype littermates were subjected to 2-weeks inhalation exposure of UFPs in a whole-body chamber. That subacute exposure did not affect the blood-brain barrier integrity or amyloid-beta accumulation. However, when multiple cytokines were analyzed, we found increased levels of proinflammatory cytokines in the brain and periphery, with a predominant alteration of interferon-gamma in response to UFP exposure in both genotypes. Following exposure, mitochondrial superoxide dismutase was significantly upregulated only in the 5xFAD hippocampi, depicting oxidative stress induction in the exposed AD mouse group. These data demonstrate that short-term exposure to inhaled UFPs induces inflammation without affecting amyloid-beta load. This study provides a better understanding of adverse effects caused by short-term UFP exposure in the brain and periphery, also in the context of AD.GRAPHICAL ABSTRACT
Talent management processes and outcomes in a virtual organization
Authors: Vecchi Alessandra , Della Piana Bice , Feola Rosangela , Crudele Chiara 
Published: September 2021

PurposeThis paper investigates how global talent management processes are adopted and implemented in a virtual organization to successfully address the challenges of global work arrangements and the sustainable human and social outcomes that can be achieved.Design/methodology/approachAdopting a single, exploratory and critical case study methodology, this paper analyzes a global distributed company, Automattic Inc., to provide in-depth and rich insights on successful business process management in the human resources (HR) domain.FindingsThe findings offer some exemplary and valuable lessons in sustainable human resource management for firms in all sectors on how to embrace global talent management in a more creative and sustainable way – and the benefits in terms of efficiency and effectiveness that can be derived – by identifying talent through auditions, recruiting by inspiring others to apply, developing talent by sharing the value of learning and retaining talent by having fun.Originality/valueThe study contributes a more rounded understanding of successful business process management in the HR domain. Due to the COVID-19 pandemic, this is particularly relevant and timely for all organizations (traditional or virtual) venturing into successful global work arrangements.
The glass slipper effect: understanding the Nordic gender equality paradox from an identity fit perspective
Authors: Spangsdorf Sabrina , Forsythe Alex 
Published: September 2021

PurposeThis paper aims to introduce an identity fit perspective adding to the understanding of the Nordic gender equality paradox of top managing positions using a Danish sample as case.Design/methodology/approachIn total, five hypotheses concerning identity perception of top managing positions and the relationship with own identity and type of industry were tested through a correlational research design utilizing a cross-sectional survey methodology. A total of 1,054 women aged 18–60 participated in the survey.FindingsThe analysis revealed a strong masculine perception of a top managing position whereas women's own identity perception was much more diverse. The more masculine a woman perceives herself to be, the more motivated she is to climb the career ladder. Type of industry moderates the relationship between identity fit and motivation for top positions, but only for the masculine traits. The relationship between identity fit and motivation is stronger for women in high masculine industries.Originality/valueApart from being the first study of identity fit in a Nordic setting, this study contributes to the identity fit theory by employing a semi-objective fit approach exploring identity fit on an industry level, including female-dominated industries, as well as examining identity fit in relation to motivation to pursue a top managing position.
Entrepreneurship and economic growth: does gender matter?
Authors: Crane Sarah R. 
Published: September 2021

PurposeEntrepreneurial firms contribute to economic growth, but the potential gendered nature of this contribution must be investigated as outcomes of male-owned and female-owned firms differ. The study investigates the female underperformance hypothesis in a cross-country analysis of Schumpeterian entrepreneurs. Next, it investigates if there is a gendered dimension of Schumpeterian firm contribution to economic growth.Design/methodology/approachThe study utilizes both nonparametric and parametric methodologies. Through nonparametric methods, the success of female-owned and male-owned firms is compared. Next, a parametric ordinary least squares regression model tests if there is a gendered nature of an entrepreneurial firm's economic contribution.FindingsIn nonparametric analyses, female-owned entrepreneurial firms in developed countries perform similarly to male-owned firms, while in developing countries male-owned firms significantly outperform female-owned firms. The author also finds strong evidence that the gender of the Schumpeterian entrepreneur does not matter in the contribution in economic growth.Research limitations/implicationsIn all countries, the number of female-owned entrepreneurial firms was significantly lower than that of male-owned firms. The findings point to consistent cultural barriers for women in innovation-related fields and persistent gendered norms in entrepreneurship. Thus, removal of cultural barriers and continued support for Schumpeterian entrepreneurship will benefit women and contribute to a country's economic growth.Originality/valueThe data for this study is a unique utilization of the Enterprise World Survey to identify Schumpeterian entrepreneurial firms. Additionally, the study challenges the female underperformance hypothesis and contributes to the literature on the role of entrepreneurship in economic growth.
Modelling supply chain risks and their impacts on the performance of the sago starch agro-industry
Authors: Anwar Syamsul , Djatna Taufik , Sukardi  , Suryadarma Prayoga 
Published: September 2021

PurposeSupply chain risks (SCRs) have uncertainty and interdependency characteristics that must be incorporated into the risk assessment stage of the SCR management framework. This study aims to develop SCR networks and determine the major risk drivers that impact the performance of the sago starch agro-industry (SSA).Design/methodology/approachThe risk and performance variables were collected from the relevant literature and expert consultations. The Bayesian network (BN) approach was used to model the uncertain and interdependent SCRs. A hybrid method was used to develop the BN structure through the expert’s knowledge acquisitions and the learning algorithm application. Sensitivity analyses were performed to examine the significant risk driver and their related paths.FindingsThe analyses of model indicated several significant risk drivers that could affect the performance of the SSA. These SCR including both operational and disruption risks across sourcing, processing and delivery stage.Research limitations/implicationsThe implementation of the methodology was only applied to the Indonesian small-medium size sago starch agro-industry. The generalization of findings is limited to industry characteristics. The modelled system is restricted to inbound, processing and outbound logistics with the risk perspective from the industry point of view.Practical implicationsThe results of this study assist the related actors of the sago starch agro-industry in recognizing the major risk drivers and their related paths in impacting the performance measures.Originality/valueThis study proposes the use of a hybrid method in developing SCR networks. This study found the significant risk drivers that impact the performance of the sago starch agro-industry.
Idea work online: shelters and crutches in remote collaborative autoethnography
Authors: Dziuba Anna , Tienari Janne , Välikangas Liisa 
Published: September 2021

PurposeThe three authors of this paper are intrigued by ideas and how they are created. The purpose of this paper is to explore idea creation and work by means of remote collaborative autoethnography.Design/methodology/approachDuring the COVID-19 lockdown in 2020, the authors sent texts to each other, followed up on each other's thoughts and discussed them in online meetings. They shared, analyzed and eventually theorized their lived experiences in order to understand creating ideas as social and cultural experience.FindingsThe authors develop the notions of “shelter” and “crutch” to make sense of the complexity of creating ideas together; theorize how emotions and identities are entangled in idea work; and discuss how time, space and power relations condition it.Originality/valueThe authors contribute to understanding idea work in a remote collaborative autoethnography by highlighting its emotional, identity-related and power-laden nature.
Talent management: four “buying versus making” talent development approaches
Authors: Cooke Gordon B. , Chowhan James , Mac Donald Kelly , Mann Sara 
Published: September 2021

PurposeThis paper presents a typology exploring employers’ perceptions of the quality of available applicants and employers decisions to buy qualified staff vs. to hire available workers and then make i.e. develop them via employer-supported training.Design/methodology/approachThis study uses 2015 survey data from Southwestern Ontario, Canada, based on responses from 834 employers regarding their hiring, separations, training and other HRM policies.FindingsAmong surveyed employers, 10% are “Reliants” who found the quality of available applicants to be low, yet these employers do not provide employee training. Almost half of employers (at 45%) are “Developers” who find the quality of applicants to be low but they do provide employee training. Approximately, 7% of employers are “Poachers” who find that the quality of applicants is high and do not provide employee training, while 38% are Refiners, who find the quality of applicants is high and they provide employee training.Originality/valueEmployers need to make their training decisions in alignment with their assessment of the quality of job applicants to whom they have access. In this paper, decisions on training and applicant quality are considered concurrently. From an academic viewpoint, the findings raise the issue as to whether other stakeholders (such as educational institutions) are sufficiently helping individuals gain the skills, credentials and work experiences that employers are seeking. If job openings are remaining unfilled because employers are unwilling to hire those available, then applicants lose, employers lose and societies lose.
Limits of arbitrage and mispricing: evidence from mergers and acquisitions
Authors: Ma Qingzhong , Whidbee David A. , Zhang Wei 
Published: September 2021

PurposeThis paper examines the extent to which noise demand and limits of arbitrage affect the pricing of acquirer stocks both at the announcement period and over the longer horizon.Design/methodology/approachAn event study approach was adopted to measure announcement-period cumulative abnormal returns. Long-horizon returns are measured using buy-and-hold abnormal returns (BHARs), calendar time portfolios (CTPRs), and subsequent earnings announcement period abnormal returns. Main methodologies include ordinary least squared (OLS) regressions, Logit regressions, and portfolio analysis.Findings(1) Acquirer stocks with high idiosyncratic volatility (the proxy for the security level characteristic most directly associated with limits to arbitrage) earn higher announcement-period abnormal returns. (2) The return pattern reverses over the subsequent longer horizon, resembling news-driven transitory mispricing. (3) The mispricing is greater when deal and firm characteristics exacerbate the limits of arbitrage, and it weakens over time. (4) Transactions by higher idiosyncratic volatility acquirers are more likely to fail.Originality/valueLimits of arbitrage theory have been tested mostly in information-free circumstances. The findings in this paper extend the supporting evidence for limits of arbitrage explaining mispricing beyond the boundaries of information-free circumstances.
Organizing worn-out neighborhoods with the new-urbanism approach using mixed methods in Rudsar, northern Iran
Authors: Askarizad Reza , Dadashpour Akram , Faghirnavaz Javad , He Jinliao , Safari Hossein 
Published: September 2021

PurposeThe vulnerability of worn-out textures in the face of natural disasters is one of the most significant challenges that have forced planners and urban managers to intervene in these structures. In this context, the new-urbanism, or the new urbanization, movement is one of the most novel approaches. This paper aims to organizing one of the worn-out neighborhoods in Rudsar, northern Iran with an approach toward the new urbanism.Design/methodology/approachThe procedure adopted in this research is a combination of both quantitative and qualitative practices with an applied approach. Therefore, through utilizing the analytical hierarchy process (AHP) and space syntax methods, the principles of the new urbanism are examined using the Expert Choice and Depthmap software. Subsequently, the appropriate priorities are mentioned for organizing the neighborhood with the new-urbanism approach using the building information system (BIM) and strengths, weaknesses, opportunities and threats (SWOT) techniques.FindingsThe findings of this study indicate that among the main characteristics of the new urbanism, walkability is recognized as the most important factor. Afterward, the components of maintaining the traditional structure of neighborhoods and connectivity were in the second and third ranks, respectively, of importance. Accordingly, by identifying the societal potential of roads according to their spatial configuration, it is possible to boost walkability, as well as economic prosperity in these areas.Originality/valueThe combination and correlation of the four utilized methods in this research can be adopted in the future studies as a new outlook of the mixed methods in the field of urban studies.
Multispecies modelling reveals potential for habitat restoration to re‐establish boreal vertebrate community dynamics
Authors: Beirne Christopher , Sun Catherine , Tattersall Erin R. , Burgar Joanna M. , Fisher Jason T. , Burton A. Cole 
Published: September 2021

Abstract

The restoration of habitats degraded by industrial disturbance is essential for achieving conservation objectives in disturbed landscapes. In boreal ecosystems, disturbances from seismic exploration lines and other linear features have adversely affected biodiversity, most notably leading to declines in threatened woodland caribou. Large‐scale restoration of disturbed habitats is needed, yet empirical assessments of restoration effectiveness on wildlife communities remain rare.

We used 73 camera trap deployments from 2015 to 2019 and joint species distribution models to investigate how habitat use by the larger vertebrate community (>0.2 kg) responded to variation in key seismic line characteristics (line‐of‐sight, width, density and mounding) following restoration treatments in a landscape disturbed by oil and gas development in northeastern Alberta.

The proportion of variation explained by line characteristics was low in comparison to habitat type and season, suggesting short‐term responses to restoration treatments were relatively weak. However, we found that lines with characteristics consistent with restored conditions were predicted to support an altered community composition, with reduced use by wolf and coyote, thereby indicating that line restoration will result in reduced contact rates between caribou and these key predators.

Synthesis and applications. Our analysis provides a framework to assess and predict wildlife community responses to emerging restoration efforts. With the growing importance of habitat restoration for caribou and other vertebrate species, we recommend longer‐term monitoring combined with landscape‐scale comparisons of different restoration approaches to more fully understand and direct these critical conservation investments. Only by combining rigorous multispecies monitoring with large‐scale restoration, will we effectively conserve biodiversity within rapidly changing environments.
Solid diet manipulates rumen epithelial microbiota and its interactions with host transcriptomic in young ruminants
Authors: Chai Jianmin , Lv Xiaokang , Diao Qiyu , Usdrowski Hunter , Zhuang Yimin , Huang Wenqin , Cui Kai , Zhang Naifeng 
Published: September 2021

SummarySolid diet supplementation in the early life stages of ruminants could improve rumen microbiota and tissue development. However, most studies focus on bacteria in the rumen content community. The microbiota attached on rumen epithelium are rarely investigated, and their correlations with rumen content bacteria and host transcripts are unknown. In this study, rumen digesta attached in the epithelium from goats in three diet regimes (milk replacer only, milk replacer supplemented concentrate and milk replacer supplemented concentrate plus alfalfa pellets) were collected for measurement of the epithelial microbiota using next generation sequencing. Correspondingly, the rumen tissues of the same animals were measured with the host transcriptome. The distinct microbial structures and compositions between rumen content and epithelial communities were associated with solid diet supplementation. Regarding rumen development in pre‐weaning ruminants, a solid diet, especially its accompanying neutral detergent fibre nutrients, was the most significant driver that influenced the rumen microbiota and epithelium gene expression. Compared with content bacteria, rumen epithelial microbiota had a stronger association with the host transcriptome. The host transcriptome correlated with host phenotypes were associated with rumen epithelial microbiota and solid diet. This study reveals that the epithelial microbiota is crucial for proper rumen development, and solid diet could improve rumen development through both the rumen content and epithelial microbiota.
Directed evolution predicts cytochrome b G37V target site modification as probable adaptive mechanism towards the QiI fungicide fenpicoxamid in Zymoseptoria tritici
Authors: Fouché Guillaume , Michel Thomas , Lalève Anaïs , Wang Nick X. , Young David H. , Meunier Brigitte , Debieu Danièle , Fillinger Sabine , Walker Anne‐Sophie 
Published: September 2021

SummaryAcquired resistance is a threat to antifungal efficacy in medicine and agriculture. The diversity of possible resistance mechanisms and highly adaptive traits of pathogens make it difficult to predict evolutionary outcomes of treatments. We used directed evolution as an approach to assess the resistance risk to the new fungicide fenpicoxamid in the wheat pathogenic fungus Zymoseptoria tritici. Fenpicoxamid inhibits complex III of the respiratory chain at the ubiquinone reduction site (Qi site) of the mitochondrially encoded cytochrome b, a different site than the widely used strobilurins which inhibit the same complex at the ubiquinol oxidation site (Qo site). We identified the G37V change within the cytochrome b Qi site as the most likely resistance mechanism to be selected in Z. tritici. This change triggered high fenpicoxamid resistance and halved the enzymatic activity of cytochrome b, despite no significant penalty for in vitro growth. We identified negative cross‐resistance between isolates harbouring G37V or G143A, a Qo site change previously selected by strobilurins. Double mutants were less resistant to both QiIs and quinone outside inhibitors compared to single mutants. This work is a proof of concept that experimental evolution can be used to predict adaptation to fungicides and provides new perspectives for the management of QiIs.
Aridity modulates belowground bacterial community dynamics in olive tree
Authors: Marasco Ramona , Fusi Marco , Rolli Eleonora , Ettoumi Besma , Tambone Fulvia , Borin Sara , Ouzari Hadda‐Imene , Boudabous Abdellatif , Sorlini Claudia , Cherif Ameur , Adani Fabrizio , Daffonchio Daniele 
Published: September 2021

SummaryAridity negatively affects the diversity and abundance of edaphic microbial communities and their multiple ecosystem services, ultimately impacting vegetation productivity and biotic interactions. Investigation about how plant‐associated microbial communities respond to increasing aridity is of particular importance, especially in light of the global climate change predictions. To assess the effect of aridity on plant associated bacterial communities, we investigated the diversity and co‐occurrence of bacteria associated with the bulk soil and the root system of olive trees cultivated in orchards located in higher, middle and lower arid regions of Tunisia. The results indicated that the selective process mediated by the plant root system is amplified with the increment of aridity, defining distinct bacterial communities, dominated by aridity‐winner and aridity‐loser bacteria negatively and positively correlated with increasing annual rainfall, respectively. Aridity regulated also the co‐occurrence interactions among bacteria by determining specific modules enriched with one of the two categories (aridity‐winners or aridity‐losers), which included bacteria with multiple PGP functions against aridity. Our findings provide new insights into the process of bacterial assembly and interactions with the host plant in response to aridity, contributing to understand how the increasing aridity predicted by climate changes may affect the resilience of the plant holobiont.