bluuebunny/crossref_metadata_2025_split huggingface dataset:
Instruments to assess Evidence-Based Practice among healthcare professionals: a systematic review
Authors: da Silva Anderson Martins , Valentim Daniela Pereira , Martins Adriana Leite , Padula Rosimeire Simprini 
Published: August 2021

AbstractThe study makes it possible to select the most appropriate instruments to evaluate the use of Evidence-Based Practice (EBP) among health professionals. The objective of this study was to assess the measurement properties, summarize and describe the instruments that evaluate the use of EBP in health professionals, currently available through the update of the systematic review. The study was conducted and reported according to recommendations of the PRISMA checklist. A systematic search was conducted in the databases: PubMed, Embase, CINAHL and ERIC. In addition, three groups of search terms: EBP terms; evaluation; cross-cultural adaptation and measurement proprieties. They included studies that showed assessment tools of EBP in healthcare workers in general publication of full-text scientific articles, which tested the measurement properties and publication of an article in English. Searches included published studies from 2006 until July 2020. Evaluation of the methodological quality of the studies was conducted according to the COSMIN initiative. 92 studies were included. Forty new instruments have been identified to assess EBP. From these, most were developed for nursing professionals and physiotherapists. More than 48% of studies have American and Australian English as their native language. Only 28% of the studies included students in the samples. Reliability was considered appropriate (sufficient) in 76% of the instruments. The COSMIN checklist classified 7 (seven) instruments as being suitable for use in the target audience. However, Fresno Test remains the most appropriate instrument for assessing the use of EBP in healthcare professionals. 40 new instruments that assess EBP have been identified. Most are consistent and reliable for measuring the use of EBP in healthcare professionals. The Fresno Test, in a list of seven reliable and valid instruments for analysis, remains the most used and the one that most assesses the domains of EBP.
A Combinatorial PCR Method for Efficient, Selective Oligo Retrieval from Complex Oligo Pools
Authors: Winston Claris , Organick Lee , Ceze Luis , Strauss Karin , Chen Yuan-Jyue 
Published: August 2021

ABSTRACTWith the rapidly decreasing cost of array-based oligo synthesis, large-scale oligo pools offer significant benefits for advanced applications, including gene synthesis, CRISPR-based gene editing, and DNA data storage. Selectively retrieving specific oligos from these complex pools traditionally uses Polymerase Chain Reaction (PCR), in which any selected oligos are exponentially amplified to quickly outnumber non-selected ones. In this case, the number of orthogonal PCR primers is limited due to interactions between them. This lack of specificity presents a serious challenge, particularly for DNA data storage, where the size of an oligo pool (i.e., a DNA database) is orders of magnitude larger than it is for other applications. Although a nested file address system was recently developed to increase the number of accessible files for DNA storage, it requires a more complicated lab protocol and more expensive reagents to achieve high specificity. Instead, we developed a new combinatorial PCR method that outperforms prior work without compromising the fidelity of retrieved material or complicating wet lab processes. Our method quadratically increases the number of accessible oligos while maintaining high specificity. In experiments, we accessed three arbitrarily chosen files from a DNA prototype database that contained 81 different files. Initially comprising only 1% of the original database, the selected files were enriched to over 99.9% using our combinatorial primer method. Our method thus provides a viable path for scaling up DNA data storage systems and has broader utility whenever scientists need access to a specific target oligo and can design their own primer regions.
The impact of public policy marketing, institutional narratives and discourses on renewable energy consumption in a developing economy
Authors: Cheah Stephanie Kay Ann , Low Brian 
Published: August 2021

PurposeThe transition from fossil fuels to renewable energy such as solar energy is difficult and requires significant ongoing public policy marketing initiatives. Drawing on institutional theory, this paper aims to explore how public policy marketing initiatives through institutional narratives and discourses legitimize solar energy's sustainable consumption in a developing economy.Design/methodology/approachUsing a post-structuralist approach, the authors undertook a thematic analysis to study the process of sustainable consumption. The authors conducted face-to-face interviews with key stakeholders in the solar energy sector and complemented the primary data with secondary analysis of archived published materials and podcasts.FindingsFirst, narratives on conformance rules and regulations (regulatory legitimacy) are significant sustainable consumption predictors of solar energy. However, the top-down regulatory legitimation narrative alone is insufficient to overcome poorly developed taken-for-granted (cognitive legitimacy) and morally correct consumption behavior (normative legitimacy), especially among the general population. Second, while consumption is primarily seen as a micro-level, residential and commercial customers phenomenon, the intersecting macro- (government) and meso-levels' (industry/market) narratives and discourses influence and direct micro-level consumption.Originality/valueFuture research agenda on legitimizing the sustainable consumption of solar energy needs to consider the dynamic interactions of institutional narratives and discourses through the lens of institutional theory and practice. Sustained, bold and provident government interventions and actions through market structure and policy issues play a crucial role in the consumption process, particularly in developing economies.
Reliability modeling and performance evaluation of solar photovoltaic system using Gumbel–Hougaard family copula
Authors: Maihulla Anas Sani , Yusuf Ibrahim , Salihu Isa Muhammad 
Published: August 2021

PurposeSolar photovoltaic (PV) is commonly used as a renewable energy source to provide electrical power to customers. This research establishes a method for testing the performance reliability of large grid-connected PV power systems. Solar PV can turn unrestricted amounts of sunlight into energy without releasing carbon dioxide or other contaminants into the atmosphere. Because of these advantages, large-scale solar PV generation has been increasingly incorporated into power grids to meet energy demand. The capability of the installation and the position of the PV are the most important considerations for a utility company when installing solar PV generation in their system. Because of the unpredictability of sunlight, the amount of solar penetration in a device is generally restricted by reliability constraints. PV power systems are made up of five PV modules, with three of them needing to be operational at the same time. In other words, three out of five. Then there is a charge controller and a battery bank with three batteries, two of which must be consecutively be in operation. i.e. two out of three. Inverter and two distributors, all of which were involved at the same time. i.e. two out of two. In order to evaluate real-world grid-connected PV networks, state enumeration is used. To measure the reliability of PV systems, a collection of reliability indices has been created. Furthermore, detailed sensitivity tests are carried out to examine the effect of various factors on the efficiency of PV power systems. Every module's test results on a realistic 10-kW PV system. To see how the model works in practice, many scenarios are considered. Tables and graphs are used to show the findings.Design/methodology/approachThe system of first-order differential equations is formulated and solved using Laplace transforms using regenerative point techniques. Several scenarios were examined to determine the impact of the model under consideration. The calculations were done with Maple 13 software.FindingsThe authors get availability, reliability, mean time to failure (MTTF), MTTF sensitivity and gain feature in this research. To measure the reliability of PV systems, a collection of reliability indices has been created. Furthermore, detailed sensitivity tests are carried out to examine the effect of various factors on the efficiency of PV power systems.Originality/valueThis is the authors' original copy of the paper. Because of the importance of the study, the references are well-cited. Nothing from any previously published articles or textbooks has been withdrawn.
Analyzing environmental sustainability enablers for an Indian steel manufacturing supply chain
Authors: Goyal Shishir , Routroy Srikanta 
Published: August 2021

Purpose
The purpose of this paper is to establish the structural relationships between the environmental sustainability enablers (ESEs) for the steel supply chain in India and also to classify them on the basis of driving and dependence power with an objective of achieving enhanced environmental sustainability performance.

Design/methodology/approach
The ESEs were identified through extensive literature review and discussion held with experts from the Indian steel industry. The interpretative structural modeling (ISM) approach was applied to an Indian steel supply chain to arrange these 12 ESEs in different hierarchies of the structural framework on the basis of their driver dependence power and also diagraph was developed to classify them.

Findings
The water pollution control system, air pollution control system and soil pollution control system were found to be in the bottom hierarchy of the ISM framework and these enablers were also observed in the driving quadrant of the diagraph. These driving enablers should be given priority for its full-scale development, management and monitoring to sustain and enhance the environmental sustainability in the Indian steel supply chain, whereas top management commitment, environment compliance certification and government regulation and incentives are the antecedents for carrying out the sustainability program.

Research limitations/implications
The outcomes of the current study are limited to the Indian steel manufacturing company in specific but the results will not change significantly for the steel sectors in India. However, an empirical analysis can be used to explore and validate the structural framework for its acceptability.

Practical implications
The outcomes from the methodology provide the basis for an Indian steel manufacturing industry to develop the right strategy in their quest for environmental sustainability.

Originality/value
Although the study on ESEs of various industries was reported in the literature, the comprehensive study to identify the significant ESEs related to the Indian steel supply chain for environmental sustainability in specific have been hardly carried out. The current study will definitely be a valuable addition to environmental sustainability literature in general and steel supply chain environmental sustainability in specific.
Knowledge, diffusion and interest in blockchain technology in SMEs
Authors: Bracci Enrico , Tallaki Mouhcine , Ievoli Riccardo , Diplotti Sonia 
Published: August 2021

Purpose
The paper aims to understand the possible determinants of knowledge of, and interest in using, blockchain, with a particular focus in the future intention to apply this technology. Blockchain technology is deemed to radically change business models and processes. Using this technology in small and medium enterprises (SMEs) is still a novel idea. Moreover, not much is known about the diffusion and level of interest towards blockchain in SMEs. This research adopts a knowledge management perspective, drawing on technology acceptance model to highlight the level of blockchain technology diffusion, and to explore which factors lead SMEs’ to adopt blockchain.

Design/methodology/approach
This study distributed a questionnaire to a sample of 300 SMEs in Italy. This study received 96 responses (32% response rate). This study calculated descriptive statistics and undertook a reliability analysis. Finally, this study performed a logistic regression to analyse the determinants of further intention to use blockchain technology.

Findings
Results show that blockchain technology is quite well known, but the level of knowledge is limited. Moreover, the research reveals that the rate of adoption is very low. Interest in the future adoption of blockchain is associated with knowledge, perception of usefulness and ease of use of blockchain.

Originality/value
This paper is one of the first explorative studies showing which factors lead SMEs to adopt blockchain technologies and shedding some light on the interaction between knowledge management and blockchain adoption and diffusion in SMEs. It highlights how blockchain knowledge could determine future interest in blockchain innovation. This paper is relevant for public and private institutions that aim to promote, through knowledge management, the adoption of blockchain in SMEs.
A phase 2b, randomized, double‐blind, multicenter, vehicle‐controlled study to assess the efficacy and safety of two crisaborole regimens in Japanese patients aged 2 years and older with mild‐to‐moderate atopic dermatitis
Authors: Fujita Kayo , Yagi Michio , Moriwaki Shinichi , Yoshida Mizuki , Graham Daniela 
Published: August 2021

AbstractAtopic dermatitis (AD) is a chronic inflammatory skin disease characterized by pruritus, xerosis, and eczematous lesions. In Japan, treatment options, such as topical corticosteroids and tacrolimus, are associated with efficacy and safety concerns. Crisaborole ointment, 2%, is a topical non‐steroidal anti‐inflammatory agent approved in several countries for the treatment of mild‐to‐moderate AD. This phase 2b, randomized, double‐blind study (NCT03954158) assessed the efficacy and safety of two crisaborole regimens versus vehicle in the treatment of Japanese patients aged ≥2 years with mild‐to‐moderate AD. Each patient was assigned to one of two age cohorts (≥12 or 2–11 years) and randomized to crisaborole once daily (QD) or twice daily (BID). All patients had two target lesions that were each randomly assigned to crisaborole or vehicle at baseline and treated for 2 weeks. The primary endpoint was change from baseline in total sign score (TSS) in crisaborole‐ or vehicle‐treated target lesions on day 15, and secondary endpoints included change from baseline in Investigator’s Static Global Assessment (ISGA) and pruritic assessments (Cohort 1: peak pruritus numeric rating scale [NRS]; Cohort 2: Itch Severity Scale Self‐Report and Caregiver‐Reported Itch Severity NRS) and incidence of treatment‐emergent adverse events (TEAEs). This study comprised 81 patients (Cohort 1: n = 41; Cohort 2: n = 40). Crisaborole‐treated lesions showed statistically significant reductions in TSS versus vehicle‐treated lesions at day 15 (p < 0.01), and numerically larger decreases in TSS were observed with crisaborole BID versus crisaborole QD in both cohorts. Furthermore, crisaborole‐treated lesions generally demonstrated greater decreases in ISGA, peak pruritus NRS, Itch Severity Scale, and Caregiver‐Reported Itch Severity NRS versus vehicle‐treated lesions irrespective of regimen or cohort. Overall, TEAEs were mild; the most frequently reported TEAEs was application site irritation. In summary, both crisaborole regimens, particularly crisaborole BID, demonstrated efficacy and were well tolerated.
Connexin 43 participates in atrial electrical remodelling through colocalization with calcium channels in atrial myocytes
Authors: Peng De‐wei , Lai Ying‐yu , Luo Xue‐shan , Li Xin , Deng Chun‐yu , Guo Hui‐ming , Zhao Jun‐fei , Yang Hui , Liu Yang , Wang Zhao‐yu , Xu Yu‐wen , Kuang Su‐juan , Wu Shu‐lin , Xue Yu‐mei , Rao Fang 
Published: August 2021

AbstractAtrial fibrillation (AF) is associated with atrial conduction disturbances caused by electrical and/or structural remodelling. In the present study, we hypothesized that connexin might interact with the calcium channel through forming a protein complex and, then, participates in the pathogenesis of AF. Western blot and whole‐cell patch clamp showed that protein levels of Cav1.2 and connexin 43 (Cx43) and basal ICa,L were decreased in AF subjects compared to sinus rhythm (SR) controls. In cultured atrium‐derived myocytes (HL‐1 cells), knocking‐down of Cx43 or incubation with 30 mmol/L glycyrrhetinic acid significantly inhibited protein levels of Cav1.2 and Cav3.1 and the current density of ICa,L and ICa,T. Incubation with nifedipine or mibefradil decreased the protein level of Cx43 in HL‐1 cells. Moreover, Cx43 was colocalized with Cav1.2 and Cav3.1 in atrial myocytes. Therefore, Cx43 might regulate the ICa,L and ICa,T through colocalization with calcium channel subunits in atrial myocytes, representing a potential pathogenic mechanism in AF.
One year effectiveness of an app‐based treatment for urinary incontinence in comparison to care as usual in Dutch general practice: A pragmatic randomised controlled trial over 12 months
Authors: Loohuis Anne MM , Van Der Worp Henk , Wessels Nienke J , Dekker Janny H , Slieker‐Ten Hove Marijke CPh , Berger Marjolein Y , Vermeulen Karin M , Blanker Marco H 
Published: August 2021

AbstractObjectiveTo assess the long‐term effectiveness of app‐based treatment for female stress, urgency or mixed urinary incontinence (UI) compared with care‐as‐usual in primary care.DesignA pragmatic, randomised controlled, superiority trial.SettingPrimary care in the Netherlands from 2015 to 2018, follow up at 12 months.PopulationWomen with two or more UI episodes per week and access to mobile apps, wanting treatment. A total of 262 women were randomised equally to app or care‐as‐usual; 89 (68%) and 83 (63%) attended 1 year follow up.InterventionsThe standalone app included conservative management for UI with motivation aids (e.g. reminders). Care‐as‐usual was delivered according to the Dutch GP guideline for UI.Main outcome measuresEffectiveness assessed by the change in symptom severity score (ICIQ‐UI‐SF) and the change in quality of life (ICIQ‐LUTSqol) with linear regression on an intention‐to‐treat basis.ResultsClinically relevant improvement of UI severity for both app (−2.17 ± 2.81) and care‐as‐usual (−3.43 ± 3.6) groups, with a non‐significant mean difference of 0.903 (−0.66 to 1.871).ConclusionApp‐based treatment is a viable alternative to care‐as‐usual for UI in primary care in terms of effectiveness after 1 year.Tweetable abstractApp‐based treatment for female urinary incontinence is a viable alternative to care‐as‐usual after 12 months.
Epidemiology, management, and prevention of exit site infections in peritoneal dialysis patients
Authors: Sachar Moniyka , Shah Ankur 
Published: August 2021

AbstractExit site infection (ESI) is a leading complication of peritoneal dialysis (PD), at an incidence of 0.6 episodes per year in the United States, and a major risk factor for catheter removal and peritonitis. An estimated 20% of all peritonitis cases are preceded by an ESI, with up to 50% of Staphylococcus aureus peritonitis associated with ESI. Gram‐negative ESIs are less associated with succeeding peritonitis than their gram‐positive counterparts, though when present, are associated with a lower peritonitis cure rate. The rate of catheter removal for refractory ESI is relatively highest in ESI due to mycobacteria (up to 40%), S. aureus (35%), Pseudomonas aeruginosa (28%), followed by Corynebacterium, Serratia, and fungi. In review of relevant literature, we found no prophylactic benefit of dressings over nondressings, specific antiseptics over normal saline, or topical honey over topical antibiotic prophylaxis, and thus recommend individualized exit site hygiene. We found topical gentamicin effective for prevention of most ESIs, including gram‐negative ESIs, and thus recommend consideration of prophylactic topical gentamicin in areas of high gram‐negative peritonitis incidence. With long‐term use, observational studies detect up to 25% of gram‐positive and 14% of gram‐negative ESIs may be mupirocin and gentamicin resistant, respectively. We review empiric and targeted ESI management, including indications for ultrasound, anti‐VMRSA, anti‐Pseudomonal, and anti‐mycobacterial antibiotic use, and catheter removal. We recommend further investigation into the earlier use of second‐line treatment agents and the utility of treating post‐infectious exit site colonization as avenues to decrease refractory and repeat ESI.
Relaxin exerts a protective effect during ischemia‐reperfusion in the rat model
Authors: Kohsaka Tetsuya , Yoneda Yoshitaka , Yoshida Takuya , Minagawa Itaru , Pitia Ali M. , Iwasawa Atsushi , Ikegaya Naoki 
Published: August 2021

AbstractBackgroundTesticular torsion, which causes ischemia‐reperfusion (IR) injury, is a serious urological emergency that can lead to testicular dysfunction, including infertility, primarily among newborn and pubertal males; thus, effective drugs should be administered during or after ischemia.ObjectivesUsing a rat model of testicular IR injury, the present study investigated the protective effects of relaxin (RLN) against oxidative stress, testicular dysfunction, inflammation, histological damage, arrested spermatogenesis, and germ cell apoptosis as well as explored the usefulness of RLN as a potential protective drug for IR injury combined with surgical treatment.Materials and methodsMale Sprague‐Dawley rats were subjected to left testicular ischemia for 2 h, followed by 24 h of reperfusion. They were subsequently divided into three groups: sham, IR, and IR + RLN groups. Porcine RLN (500 ng/h) or saline was infused using an implanted osmotic mini‐pump 90 min after inducing ischemia. The RLN dose used herein was that which resulted in serum RLN levels comparable to those in mid‐pregnant rats based on previous studies.ResultsTesticular IR increased germ cell apoptosis and histological damage as well as promoted disorganized and arrested spermatogenesis, accompanied by a significant increase in oxidative stress and inflammation. However, RLN administration ameliorated the adverse consequences associated with IR injury by attenuating oxidative stress and mitigating apoptosis and inflammation.Discussion and conclusionThe study findings clearly demonstrated that RLN exerts a protective effect against IR‐induced testicular injury by attenuating oxidative stress, apoptosis, and inflammation, suggesting that RLN together with surgical treatment is a potentially efficacious approach toward ameliorating testicular dysfunction following testicular torsion.
Conspiracy beliefs and the impact on health behaviors
Authors: Kroke Abigail M. , Ruthig Joelle C. 
Published: August 2021

AbstractHealth‐related conspiracy beliefs are widespread, cover a variety of health topics, and can impact behavior. As such, understanding exactly how these beliefs impact health behavior is an important step in developing interventions to increase preventative health behaviors and individuals' overall health and well‐being. This review assesses two different widely endorsed health‐related conspiracy beliefs using two key health models, the Theory of Planned Behavior (TPB; Ajzen, 1985) and the Health Belief Model (HBM; Rosenstock et al., 1988, https://doi.org/10.1177/109019818801500203), in order to determine how these beliefs may impact health behavior and possible avenues for intervention. Attitudes and subjective norms from the TPB, along with perceived severity, barriers, and benefits from the HBM, were the most salient to conspiracy beliefs. Future research should consider a mixed model approach that utilizes components from both theories in intervention planning and assessment.