bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can competitors cooperate? The impact of formal institution agents in promoting coopetition among emerging market exporters
Authors: Monticelli Jefferson Marlon , Garrido Ivan Lapuente , Vieira Luciana Marques , Chim-Miki Adriana Fumi , Carneiro Jorge 
Published: December 2021

Purpose
This paper aims to investigate the effects of formal institution agents on export performance, mediated by coopetition. It presents novel scales for evaluating firms’ adherence to cooperation agreements with competitors, identifying coopetition networks’ main motives and goals. The study also focuses on the relationship between the export performance of small and medium enterprises from emerging markets and coopetition strategies.

Design/methodology/approach
The study adopts a quantitative methodology using multivariate and confirmatory methods. The sample comprised 166 firms from three different industries in an emerging market (Brazil).

Findings
The results indicate that adherence to formal institution agents promotes cooperation among competitors and that such coopetition tends to improve export performance. The role played by formal institution agents minimizes the paradoxical tension and fosters coopetitive performance. Firms in developing markets look to mediated coopetition to achieve coopetitive advantages. They cooperate to create collective advantages from shared resources, but they do not lose sight of the ultimate objective of appropriating these advantages. The cycle of creation and appropriation of advantages is fostered by the formal institution agent, acting as the conductor of an orchestra, coordinating movements and setting the rhythm for the partners. The institutional agent, thus, constitutes an important hub of the coopetition network.

Originality/value
The paper contributes to understanding a type of coopetition that has hitherto been underexplored in the literature – mediated coopetition.
Does working from home work? Experience of working from home and the value of hybrid workplace post-COVID-19
Authors: Yang Eunhwa , Kim Yujin , Hong Sungil 
Published: December 2021

Purpose
This study aims to understand how knowledge workers working from home during COVID-19 changed their views on physical work environments and working-from-home practices.

Design/methodology/approach
This study conducted a survey targeting workers in the USA recruited via Amazon Mechanical Turk. A total of 1,651 responses were collected and 648 responses were used for the analysis.

Findings
The perceived work-life balance improved during the pandemic compared to before, while the balance of physical boundaries between the workplace and home decreased. Workplace flexibility, environmental conditions of home offices and organizational supports are positively associated with productivity, satisfaction with working from home and work-life balance during the pandemic.

Research limitations/implications
While the strict traditional view of “showing” up in the office from Monday through Friday is likely on the decline, the hybrid workplace with flexibility can be introduced as some activities are not significantly affected by the work location, either at home-based or corporate offices. The results of this study also highlight the importance of organizations to support productivity and satisfaction in the corporate office as well as home. With the industry collaboration, future research of relatively large sample sizes and study sites, investigating workers’ needs and adapted patterns of use in home-based and corporate offices, will help corporate real estate managers make decisions and provide some level of standardization of spatial efficiency and configurations of corporate offices as well as essential supports for home offices.

Originality/value
The pandemic-enforced working-from-home practices awaken the interdependence between corporate and home environments, how works are done and consequently, the role of the physical workplace. This study built a more in-depth understanding of how workers who were able to continue working from home during COVID-19 changed or not changed their views on physical work environments and working-from-home practices.
Algorithms and venture investment decisions: better, fairer or biased?
Authors: Levy Matthew , Liguori Eric 
Published: December 2021

PurposeThis paper is a rejoinder to the work of Blohm, Antretter, and colleagues recently published in both Entrepreneurship Theory and Practice and Harvard Business Review titled “It's a Peoples Game, Isn't It?! A Comparison Between the Investment Returns of Business Angels and Machine Learning Algorithms” and “Do Algorithms Make Better – and Fairer – Investments than Angel Investors?”, respectively.Design/methodology/approachWhile we agree with authors of prior scholarship on the importance of counteracting human biases, honing expert intuition and optimizing the odds of success in investment decision-making contexts, in the spirit of open academic discourse, this paper respectfully challenges some of the underlying assumptions concerning algorithmic bias on which prior work is based.FindingsInvesting remains part art and part science, and while algorithms may begin to play a more significant role in investment decision-making, human intuition remains hard to imitate. In both people and in algorithms, sources of bias remain both implicit and explicit and often have systemic roots, so more research continues to be needed to fully understand why algorithms produce potentially biased outcomes across a wide array of contexts.Originality/valueThis paper contributes to our collective understanding on the use of algorithms in making investment decisions, highlighting the fact that bias exists in humans and algorithms alike, even when the best of intentions are present.
Die Überkinder: Nietzsche and Greta Thunberg, children and philosophy
Authors: Verharen Charles C 
Published: December 2021

Abstract
Does Nietzsche imagine that an Überkind could prepare the path for an Übermensch? Linking Nietzsche to Greta Thunberg through their mutual concern about life's future, this essay reviews Nietzsche's 1871 through 1888 research on preparing children for a task demanding nearly superhuman powers: guaranteeing life's future against human irrationality's assaults. Rather than offering a historical analysis, the essay views his remarks as promptings for developing a curriculum for philosophy's engagement with children. The essay presents foundational principles for a curriculum for children that addresses current existential crises by promoting creativity's role in that curriculum. The conclusion summarises Nietzsche's vision of philosophy's future.
A comprehensive review on the properties and functionalities of biodegradable and semibiodegradable food packaging materials
Authors: Weligama Thuppahige Vindya Thathsaranee , Karim Md Azharul 
Published: December 2021

AbstractThe development of biodegradable food packaging with superior properties and functionalities compared to conventional food packaging is one of the emerging research interests. Immediate disposal of conventional single use nonbiodegradable food packaging results in adverse environmental impact. Utilization of either biomass‐based, microorganism‐derived, or biotechnologically synthesized biopolymers as biodegradable matrices is the common approach toward achieving sustainability. Consequently, starch and cellulose are being commonly used as biodegradable matrices. However, rather than being fully biodegradable, most of them can be considered as semibiodegradable. Majority of the review studies are based on matrices that have an origin in edible sources, which might result in food insecurity. Although development of bio‐based polymers with sound packaging properties have been extensively studied, the potential agro‐industrial waste as alternative, eco‐friendly, and economically viable matrices have attracted little attention. Therefore, the approaches of developing biodegradable food packaging and the framework of converting agro‐industrial waste into biodegradable packaging matrices are discussed comparatively in this paper. It also critiques the approaches and valorization of agro‐industrial waste in biodegradable food packaging. Thereby, an overview of physicochemical, functional, and biodegradable properties of commonly used biodegradable food packaging materials are provided as an insight for agro‐industrial waste‐based food packaging. The potential use of agro‐industrial waste‐based biodegradable food packaging materials against commonly used biodegradable food packaging materials has been highlighted in this study. Thereby, the vital necessity of growing awareness about agro‐industrial waste as biodegradable food packaging materials is emphasized through this comprehensive review.
Diagnostic codes for low back pain, nomenclature or noise? A descriptive study of disease classification system coding of low back pain
Authors: Tamrakar Mamata , O’Keeffe Mary , Traeger Adrian C. , Harris Ian , Maher Christopher 
Published: December 2021

AbstractAimTo compare and contrast the diagnostic codes for spinal causes of low back pain (LBP) in 3 disease classification systems (International Classification of Diseases [ICD]‐10, International Classification of Primary Care [ICPC]‐2 PLUS and Systematized Nomenclature of Medicine Clinical Terms ‐ Australia [SNOMED CT‐AU]) and consider how well they are aligned with the diagnostic approach recommended in contemporary clinical practice guidelines for LBP.MethodThis was a descriptive study which included 3 disease classification systems: ICD‐10, ICPC‐2 PLUS and SNOMED CT‐AU. Two independent authors extracted relevant LBP codes from each system and mapped the codes to 3 guideline‐endorsed categories of spine‐related diagnoses for LBP (specific spinal pathology, radicular syndromes, and non‐specific LBP) and the various clinical conditions (sub‐categories) within each of the 3 categories.ResultsICD‐10, ICPC‐2 PLUS, and SNOMED CT‐AU had 126, 118 and 100 codes for LBP, respectively. All systems provided codes that would cover the 3 guideline‐endorsed categories of spine‐related diagnoses for LBP. On the basis of contemporary guidelines, the authors developed lists of discrete sub‐categories of specific spinal pathology (56 sub‐categories), radicular syndromes (7 sub‐categories), and non‐specific LBP (10 sub‐categories). Each of the classification systems was then mapped against these sub‐categories to tally redundancy and determine exhaustiveness. However, no system covered all 73 sub‐categories of LBP, and within each system, there was substantial redundancy with up to 22 codes for the same clinical condition.ConclusionLBP diagnostic codes used in popular disease classification systems are out of touch with current approaches to diagnosis, as reflected in contemporary LBP guidelines. Our findings suggest these disease classification systems need revision, but precisely how they should be revised is unclear.
Risk factors for pulmonary complications after neoadjuvant chemoradiotherapy followed by surgery for non‐small cell lung cancer
Authors: Kim Ha Eun , Yu Woo Sik , Lee Chang Young , Lee Jin Gu , Kim Dae Joon , Park Seong Yong 
Published: December 2021

AbstractBackgroundWe aimed to investigate the characteristics and pretreatment risk factors for postoperative pulmonary complications (PPCs) after neoadjuvant concurrent chemoradiotherapy (CRTx) in patients with non‐small cell lung cancer (NSCLC).MethodsWe retrospectively reviewed data of 122 patients who underwent curative resection after neoadjuvant CRTx for NSCLC between 2007 and December 2019. Clinical data, including pulmonary function and body mass index (BMI) at the time of concurrent CRTx initiation, were analyzed. We performed logistic regression analyses to identify the risk factors for PPCs and built a nomogram with significant factors.ResultsOf the 122 patients included (mean age, 60.1 ± 9.7 years; 69.7% male), 27 experienced PPCs (severity grade ≥ 2). The most common PPCs were pneumonia (n = 17). Patients with PPCs had a significantly longer hospital stay (median 6.0 vs. 17 days, p < 0.001) and a higher in‐hospital mortality rate (1.1% vs. 29.6%, p < 0.001). In multivariable analysis, lower BMI (odds ratio [OR] 0.796, 95% confidence interval [CI] 0.628–0.987, p = 0.038), no comorbidity (OR 0.220, 95% CI: 0.059–0.819, p = 0.048), smoking history (OR 4.362, 95% CI: 1.210–15.720, p = 0.024), and %predicted DLCO <60% (OR 3.727, 95% CI: 1.319–10.530, p = 0.013) were independent risk factors for PPCs. The predictive accuracy of the nomogram built with factors was excellent (concordance index: 0.756).ConclusionsThe nomogram constructed with factors identified in multivariable analysis could serve as a reliable tool for evaluating the risk of PPCs in the patients who underwent neoadjuvant CRTx for NSCLC.
Export development in New Zealand: Kiwifruit and seafood 1975–1985
Authors: McAloon Jim 
Published: December 2021

AbstractThis paper discusses export development in New Zealand in the 1970s and 1980s with reference to the long‐running literature about the sustainability of natural resource‐based growth, export diversification, and the role of state regulation and encouragement. Since 1970 New Zealand's export commodity mix has diversified. Pastoral exports, once dominant, are complemented by seafood, wine, fruit, vegetables, forest products and a range of manufactured goods. Diversification of export markets and commodities was a priority for policymakers from the mid‐1950s, and more so from the mid‐1970s. Export incentives were a chosen instrument. Seafood and kiwifruit were among the most significant examples of primary sector diversification. The paper finds that the circumstances of each industry required different government policies, and that entrepreneurship and innovation were significant alongside government policy.
Efficacy, toxicity, and quality‐of‐life outcomes of ultrahypofractionated radiotherapy in patients with localized prostate cancer: A single‐arm phase 2 trial from Asia
Authors: Tan Janice S. H. , Teh Jonathan Y. H. , Tan Laura L. Y. , Tan Sheena X. F. , Li You Quan , Tan Terence W. K. , Wang Michael L. C. , Kanesvaran Ravindran , Ong Enya H. W. , Tay Kae Jack , Lee Lui Shiong , Tuan Jeffrey K. L. , Tan Daniel Y. H. , Chua Melvin L. K. 
Published: December 2021

AbstractAimsUltra‐hypofractionated radiotherapy (UHF‐RT) is widely utilized in men with localized prostate cancer (PCa). There are limited data in Asian cohorts. We report the outcomes of a single‐arm, phase II trial of UHF‐RT from an Asian center.MethodsWe recruited men with histologically confirmed, nonmetastatic localized PCa. UHF‐RT regimens were 36.25 Gy (Cohort A) and 37.5 Gy (Cohort B) delivered in five fractions every other day over 1.5–2.5 weeks. Primary endpoint was physician‐scored late genitourinary (GU) and gastrointestinal (GI) adverse events (AEs). Quality‐of‐life (QoL) was assessed by Expanded Prostate Cancer Index Composite (EPIC) at baseline, 1‐ and 2‐year post‐UHF‐RT.ResultsBetween March 2014 and August 2019, 105 men were recruited; four were subsequently excluded from analysis. Median age was 68.0 (Interquartile range (IQR): 63.8–73.0) years. 26 (24.8%) and 68 (64.8%) men had NCCN‐defined low‐and intermediate‐risk PCa, respectively. No late ≥G3 GU or GI toxicities were reported in both cohorts. Peak incidence of acute ≥G2 GU AEs at 14 days post‐UHF‐RT was 23.6% (17/72) and 24.0% (6/25) in Cohorts A and B, respectively; ≥G2 GI AEs were observed in 9.7% (7/72) and 36.0% (9/25), respectively. Late ≥G2 GU and GI AEs occurred in 4.7% and 3.1% of Cohort A patients, and 5.0% in Cohort B at 12 months, with no AEs at 24 months. EPIC scores changed minimally across all domains. At a median follow‐up of 44.9 months, we recorded one (1.3%) biochemical relapse by the Phoenix criteria (Cohort A).ConclusionUHF‐RT is well tolerated in Asian men and can be a recommended fractionation schema for localized PCa.
Letter: proton pump inhibitors and risk of myocardial infarction—authors' reply
Authors: Nolde Michael , Ahn Nayeon , Dreischulte Tobias , Rückert‐Eheberg Ina‐Maria , Güntner Florian , Günter Alexander , Gerlach Roman , Tauscher Martin , Amann Ute , Linseisen Jakob , Meisinger Christa , Baumeister Sebastian‐Edgar 
Published: December 2021

LINKED CONTENTThis article is linked to Nolde et al papers. To view these articles, visit https://doi.org/10.1111/apt.16565 and https://doi.org/10.1111/apt.16644
Editorial: twenty minutes of moderate‐to‐vigorous physical activity a day keeps the NAFLD away—authors' reply
Authors: Tsunoda Kenji , Kitano Naruki , Kai Yuko , Jindo Takashi , Uchida Ken , Arao Takashi 
Published: December 2021

LINKED CONTENTThis article is linked to Tsunoda et al papers. To view these articles, visit https://doi.org/10.1111/apt.16631 and https://doi.org/10.1111/apt.16662
Editorial: targeting liver biopsy in NAFLD—the need to expand our non‐invasive tools. Authors’ reply
Authors: Kim Hannah P. , Mospan Andrea R. , Fried Michael W. , Barritt Alfred Sidney ,   TARGET‐NASH Investigators
Published: December 2021

LINKED CONTENTThis article is linked to Kim et al papers. To view these articles, visit https://doi.org/10.1111/apt.16674 and https://doi.org/10.1111/apt.16705
Pes varus correction in dachshunds with mini hybrid external skeletal fixators
Authors: Chau L , Wilson L 
Published: December 2021

AimTo evaluate the clinical and radiographic outcome of pes varus deformity correction in dachshunds managed with acute medial opening wedge osteotomy of the distal tibia and stabilised with a mini hybrid external skeletal fixator (HESF).MethodsSurgical correction involved a transverse osteotomy over the premeasured location at the distal tibia and application of a IMEX mini HESF. All corrections were evaluated using centre of rotation and angulation methodology.ResultsMedical records and radiographies of 20 dachshunds (28 pes varus corrections) were reviewed. All osteotomies healed and fixators were removed between 6 and 12 weeks. Lameness resolved in 18 dachshunds (90%) and significantly improved in two dachshunds (10%). Lateral patella luxation (LPL) was detected in 11/28 (39.2%) of the involved pelvic limbs, all of which resolved following pes varus correction. Mean frontal plane alignment (FPA) of the normal and abnormal tibiae were 12.3° valgus (range: 4°–18°) and 25° Varus (range: 16°–41°) respectively. Angular correction ranged between 30° and 50° (Mean: 39°) and the mean post‐operative FPA was 13° valgus (range: 5°–21°).Clinical significancePes varus deformity in dachshunds can be corrected by medial opening wedge osteotomy of the distal tibia stabilised by HESF. Single‐session bilateral pes varus corrections can also be performed with minimal morbidity. LPL was commonly detected in dogs with pes varus deformity and all resolved spontaneously following pes varus correction alone.
The association of polypharmacy with functional decline in elderly patients undergoing cardiac surgery
Authors: Arends Britta C. , Blussé van Oud‐Alblas Heleen J. , Vernooij Lisette M. , Verwijmeren Lisa , Biesma Douwe H. , Knibbe Catherijne A. J. , Noordzij Peter G. , van Dongen Eric P. A. 
Published: December 2021

AimsIdentifying preoperative risk factors in older patients becomes more important to reduce adverse functional outcome. This study investigated the association between preoperative medication use and functional decline in elderly cardiac surgery patients and compared polypharmacy as a preoperative screening tool to a clinical frailty assessment.MethodsThis sub‐study of the Anaesthesia Geriatric Evaluation study included 518 patients aged ≥70 years undergoing elective cardiac surgery. The primary outcome was functional decline, defined as a worse health‐related quality of life or disability 1 year after surgery. The association between polypharmacy (i.e. ≥5 prescriptions and <10 prescriptions) or excessive polypharmacy (i.e. ≥10 prescriptions) and functional decline was investigated using multivariable Poisson regression. Discrimination, calibration and reclassification indices were used to compare preoperative screening tools for patient selection.ResultsFunctional decline was reported in 284 patients (55%) and preoperative polypharmacy and excessive polypharmacy showed higher risks (adjusted relative risk 1.57, 95% confidence interval [CI] 1.23–1.98 and 1.93, 95% CI 1.48–2.50, respectively). Besides cardiovascular medication, proton‐pump inhibitors and central nervous system medication were significantly associated with functional decline. Discrimination between models with polypharmacy or frailty was similar (area under the curve 0.67, 95% CI 0.61–0.72). The net reclassification index improved when including polypharmacy to the basic model (17%, 95% CI 0.06–0.27).ConclusionPolypharmacy is associated with functional decline in elderly cardiac surgery patients. A preoperative medication review is easily performed and could be used as screening tool to identify patients at risk for adverse outcome after cardiac surgery.
Novel long‐acting ropeginterferon alfa‐2b: Pharmacokinetics, pharmacodynamics and safety in a phase I clinical trial
Authors: Huang Yi‐Wen , Qin Albert , Fang Jane , Wang Ting‐Fang , Tsai Chung‐Wei , Lin Ko‐Chung , Teng Ching‐Leou , Larouche Richard 
Published: December 2021

AimsRopeginterferon alfa‐2b is a novel, long‐acting pegylated interferon alfa‐2b. We aimed to evaluate its safety, pharmacokinetics (PK) and pharmacodynamics (PD).MethodsThirty‐six subjects received single subcutaneous injection of ropeginterferon alfa‐2b at doses ranging from 24 to 270 μg, and 12 subjects received pegylated IFN alfa‐2a subcutaneously at 180 μg. Primary endpoints were safety/PK profiles of ropeginterferon alfa‐2b, while secondary endpoints were to compare PK/PD parameters with pegylated IFN alfa‐2a.ResultsAdverse events in ropeginterferon alfa‐2b and pegylated IFN alfa‐2a groups were similar, and most of them were mild or moderate. Mean Cmax increased from 1.78 to 24.84 ng/mL along with the dose escalations in ropeginterferon alfa‐2b groups and was 12.95 ng/mL for pegylated IFN alfa‐2a. At 180 μg, ropeginterferon alfa‐2b showed statistically significant Cmax geometric mean ratio (1.76; P = .0275). Mean Tmax ranged from 74.52 to 115.69 h for ropeginterferon alfa‐2b groups, and was 84.25 h for pegylated IFN alfa‐2a. Mean AUC0‐t increased from 372.3 to 6258 ng•h/mL with the dose escalations in the ropeginterferon alfa‐2b groups, while for pegylated IFN alfa‐2a it was found to be 2706 ng•h/mL in pegylated IFN alfa‐2a. For neopterin and 2′,5′‐oligoadenylate synthase, mean Emax, Tmax and AUC0‐t of ropeginterferon alfa‐2b were similar to those of pegylated IFNα‐2a at 180 μg.ConclusionRopeginterferon alfa‐2b up to 270 μg was safe and well tolerated. The PK/PD parameters of ropeginterferon alfa‐2b showed increase in dose–response. Ropeginterferon alfa‐2b had higher drug exposures and showed similar safety profile when compared to pegylated IFN alfa‐2a at the same dose level.