bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategies Used by Middle Managers to Support Employees Carrying Out Emotionally Demanding Work: Which Strategies and Why Those Ones?
Authors: Pelletier-Bosshard Emma , Freeman Andrew , Jauvin Nathalie , Côté Nancy 
Published: March 2021

Many areas of practice in health and social services are emotionally demanding. This type of work can be associated with psychological health problems and middle managers play a key role in reducing such risks for their staff. Although the importance of providing this support is recognized, attaining such an objective is not necessarily straightforward because of the multiple demands that managers must juggle.
Using an ergonomic perspective, this qualitative research study, which was conducted in a regional child protection service in Quebec (Canada), aimed to identify the strategies used by middle managers to support staff whose work is considered emotionally demanding. The results reveal that managers use a range of support strategies, which fall into seven categories. Although the strategies are distributed along two axes, proximity (direct, indirect) and time (short-term, long-term), they tend to be more direct and short-term (e.g., provide emotional support). The choice of strategies is influenced by various facilitating or constraining organizational, interpersonal and individual factors. A strong influence appears to be time availability.
This study provides a detailed picture of the strategies used by middle man-agers and the complexity with which these individuals are confronted in providing their staff with support. Further research is required, for example, to better understand the impact of certain factors on the choice of support strategies and to evaluate the impact of support strategies from a staff perspective.
Listening Backward: Sonic Intimacies and Cross-Racial, Queer Resonance
Authors: Hale Wood Katelyn 
Published: March 2021

Documenting my encounters as a white queer scholar with the sonic archive of the late black American lesbian comic Jackie “Moms” Mabley, this paper explores the cross-racial/sexual politics of sonic historiography. Through what I term listening backward, I examine how sound procures queer sonic intimacies between critic and subject: the repetitive listening, soundwaves directly travelling from one voice to one person, and most pertinently, the historical and sociocultural contexts that make consumption of such exchange possible and/or fraught. This listening practice centres on relational and resonant modes of archiving through sound and asks: (1) How can exploring methods of sonic documentation align performance studies’ commitment to archiving the affective? (2) What might attention to not only the product of such documentation but also its performative processes offer about how the sonic can deepen modes of performance historiography and the racial/sexual politics of listening? (3) What practices of listening can centre queer intimacies and temporalities in the archive?
Architectural Space in Ancient Greece
Authors: Doxiadis Constantinos A. 
Published: March 2021

Doxiadis is best known as an architect-planner, as a consultant with an international clientele, as something of a prophet whose outlook is focused on man's worldwide future. But here, in his first major study, originally published in German in 1937, Doxiadis looks back into the past, to the architectural roots of his native Greece.
He works out a theory that accounts for the seemingly unordered layout of the buildings in ancient Greek sacred precincts, proposing that the spatial relationships between the buildings were strictly determined according to a plan.
Doxiadis examines in detail nearly thirty sites, charts their layouts, and presents relevant linear and angular measurements. Numerous site plans and about forty halftones complement the text. The full references include many recent sources. The trim size of the book itself is proportioned by means of the golden section.
Modernity and Housing
Authors: Rowe Peter G. 
Published: March 2021

Peter Rowe explores the social, cultural, and expressive history of housing at two crucial moments: the first large-scale developments along modernist lines in the 1920s, and the widespread reconsideration of modernist principles in the 1970s.
Starting from the question of how can the design of modern housing can be successful, Peter Rowe explores the social, cultural, and expressive history of housing at two crucial moments: the first large-scale developments along modernist lines in the 1920s, and the widespread reconsideration of modernist principles in the 1970s. Although the inquiry is conducted along historical and theoretical lines, it proposes to uncover practical principles that may guide the design of modern housing, each principle responding to a contemporary architectural paradox posed by modern conditions. Six detailed case studies form the illustrative centerpiece of the book. Modernity and Housing embraces three more or less parallel themes concerning modernity: the rise of technocracy and the attendant tendency of modern space to become universal while the experience of time is confined to the present; the problem of representation for a culture in which subject-centered reason has replaced metaphysical foundations; and social practices that give rise to urban concentrations and the production of mass housing on an unprecedented scale. Within these themes, the modern experience of space and time philosophically grounds discussion of local and traditional versus universal and novel building practices. The perspective of subject-centered reason grounds the exploration of the use of abstract forms and the comcomitant problem of providing for an expressive architectural language; while the unprecedented quantities of housing production raise the thorny issue of widely defining a normative building program that allows for local particularity. The case studies cover Sunnyside Gardens, New York; Romerstadt, Frankfurt-am-Main; Kiefhoek, Rotterdam; Byker Redevelopment, United Kingdom; Villa Victoria, United States; Malagueira Quarter, Portugal. An appendix contains an annotated and statistical summary of all major housing projects described in the text (about 40) with notes that include the date, size, place, architect, client, housing type, relative densities, and other items of interest.
Surveillance of tuberculosis and treatment outcomes following screening and therapy interventions among marriage-migrants and labor-migrants from high TB endemic countries in Taiwan
Authors: Kuan Mei-Mei 
Published: March 2021

Background
Tuberculosis (TB) among migrants from high-risk countries and underling interventions were concerned for disease control. This study aimed to assess the TB trends among marriage-migrants with the 1–2-round vs. labor-migrants with the four-round TB screenings in the period of the first four post-entry years; pre-entry screenings by an initial chest X-ray (CXR) were conducted during 2012–2015, and a friendly treatment policy was introduced in 2014.

Methods
TB data of migrants during 2012–2015 were obtained from the National TB Registry Database and analyzed. The incidences, clinical characteristics, and treatment outcomes were assessed to explore the impact of underlying interventions.

Results
During post-entry 0–4 years, the TB incidence rates among marriage-migrants ranged 11–90 per 100,000 person-years, with 60.8% bacteria-positive and 28.2% smear-positive cases. Whereas among labor migrants, the incidence rates ranged 67–120 per 100,000 person-years, with 43.6% bacteria-positive and 13.7% smear-positive cases. All migrants originated from Southeast Asia following pre-entry health screening in 2012–2015. The TB cases among marriage-migrants were with a higher proportion of sputum-smear-positivity (SS+) (OR: 4.82, 95% CI [3.7–6.34]) and CXR cavitation (OR: 2.90, 95% CI [2.10–4.01]). Marriage-migrants with TB had treatment completion rate of >90%, which was above the WHO target. For labor-migrants with TB, when compared the period of post- vs. pre-implementation of the friendly therapy policy that eliminated compulsory repatriation, the overall treatment completion rate of those who stayed in Taiwan improved by 30.9% (95% CI [24.3–37.6]) vs. 6.7% (95% CI [3.8–9.7]), which exceeded a 4.88-fold (95% CI: 3.83–6.22) improvement. Additionally, the treatment initiation rate within 30 days of diagnosis for SS- TB and B- TB cases during post- vs. pre-implementation of the therapy policy was increased, that is, 77.1% vs. 70.9% (OR: 1.38, 95% CI [1.12–1.70]) and 78% vs. 77% (OR: 1.64, 95% CI [1.38–1.95]).

Conclusion
Multiple CXR screenings could identify more TB cases with sputum-smear-negativity (SS-) TB at the early-stage, introducing latent tuberculosis infection (LTBI) screening might save underlying efforts. For those labor-migrants with TB who stayed in the receiving country, the friendly TB therapy policy not only significantly improved the treatment completion but also the early treatment initiation.
Direct-acting antiviral treatment for Hepatitis C Virus in geriatric patients: a real-world retrospective comparison between early and late elderly patients
Authors: Yen Hsu-Heng , Su Pei-Yuan , Liu I-Ling , Zeng Ya-Yuei , Huang Siou-Ping , Hsu Yu-Chun , Yang Chia-Wei , Chen Yang-Yuan 
Published: March 2021

Introduction
Chronic hepatitis C virus (HCV) infection rates are high in the geriatric population considering that interferon-based therapy is usually intolerable. With the introduction of oral antiviral therapy for HCV, increased treatment tolerability and good treatment responses have been observed. However, treatment data regarding the geriatric population have been limited. Therefore, this retrospective study aimed to evaluate the efficacy and safety of direct-acting antiviral therapy for HCV in the geriatric population.

Materials and Methods
The primary end point was sustained virologic response (SVR) 12 weeks after treatment completion, whereas the secondary end points were treatment-related side effects and short-term survival rate following treatment.

Results
In total, 492 patients (median age, 73 years; 43.9% males), including 278 early elderly patients, were enrolled. Among the included patients, 45% had cirrhosis. HCV genotypes 1 (72.4%) and 2 (25.4%) were the most common. The overall SVR rate was 96.7%, with no difference in SVR rates observed between early and late elderly groups (96.8% vs. 96.7%; p = 0.983). Both groups showed similar side effects, including dizziness (11.4%), and fatigue (8.7%), with three patients discontinuing therapy owing to side effects. Both groups had a similar 3-year survival rate. Significant factors associated with post-treatment survival included cirrhosis, albumin, and creatinine level.

Conclusions
Our real-world data showed that both early and late elderly patients could undergo direct-acting antiviral treatment for HCV with excellent treatment outcomes.
Transcriptome profiling reveals histone deacetylase 1 gene overexpression improves flavonoid, isoflavonoid, and phenylpropanoid metabolism in Arachis hypogaea hairy roots
Authors: Su Liangchen , Liu Shuai , Liu Xing , Zhang Baihong , Li Meijuan , Zeng Lidan , Li Ling 
Published: March 2021

Background
The peanut (Arachis hypogaea) is a crop plant of high economic importance, but the epigenetic regulation of its root growth and development has not received sufficient attention. Research on Arabidopsis thaliana has shown that histone deacetylases (HDACs) are involved in cell growth, cell differentiation, and stress response. Few studies have focused on the role of HDACs in the root development of other plants, particularly crop plants. In earlier studies, we found large accumulations of A. hypogaea histone deacetylase 1 (AhHDA1) mRNA in peanut roots. However, we did not explore the role of AhHDA1 in peanut root development.

Methods
In this paper, we investigated the role of the peanut AhHDA1 gene and focused on the effect of altered AhHDA1 expression in hairy roots at both the phenotypic and transcriptional levels. We analyzed the transformation of A. hypogaea hairy roots using Agrobacterium rhizogenes and RNA sequencing to identify differentially expressed genes that were assigned to specific metabolic pathways. Transgenic hairy roots were used as experimental material to analyze the downstream genes expression and histone acetylation levels. To thoroughly understand AhHDA1 function, we also simultaneously screened the AhHDA1-interacting proteins using a yeast two-hybrid system.

Results
AhHDA1-overexpressing hairy roots were growth-retarded after 20 d in vitro cultivation, and they had a greater accumulation of superoxide anions and hydrogen peroxide than the control and RNAi groups. AhHDA1 overexpression in hairy roots accelerated flux through various secondary synthetic metabolic pathways, as well as inhibited the primary metabolism process. AhHDA1 overexpression also caused a significant upregulation of genes encoding the critical enzyme chalcone synthase (Araip.B8TJ0, CHS) in the flavonoid biosynthesis pathway, hydroxyisoflavanone synthase (Araip.0P3RJ) in the isoflavonoid biosynthesis pathway, and caffeoyl-CoA O-methyltransferase (Aradu.M62BY, CCoAOMT) in the phenylpropanoid biosynthesis pathway. In contrast, ferredoxin 1 (Araip.327XS), the polypeptide of the oxygen-evolving complex of photosystem II (Araip.N6ZTJ), and ribulose bisphosphate carboxylase (Aradu.5IY98) in the photosynthetic pathway were significantly downregulated by AhHDA1 overexpression. The expression levels of these genes had a positive correlation with histone acetylation levels.

Conclusion
Our results revealed that the relationship between altered gene metabolism activities and AhHDA1 overexpression was mainly reflected in flavonoid, isoflavonoid, and phenylpropanoid metabolism. AhHDA1 overexpression retarded the growth of transgenic hairy roots and may be associated with cell metabolism status. Future studies should focus on the function of AhHDA1-interacting proteins and their effect on root development.
Chemical Composition of Essential Oil of Ageratum conyzoides with Antifungal Activity on the Lasiodiplodia theobromae Strain in the Region of Kisangani and DR Congo
Authors: Kwembe J. T. K. , Onautshu O. , Mpiana P. T. , Vermeir Pieter , Haesaert G. 
Published: March 2021

Aims: To determine the chemical composition of essential oil of Ageratum conyzoides with antifungal activity on the strain of Lasiodiplodia theobromae in the Kisangani region.
Location and Duration of Studies: Faculty of Sciences of University of Kisangani (Democratic Republic of Congo) and Faculty of Biosciences Engineering of University of Ghent (Belgium), between May to November 2019.
Methodology: The essential oil from the leaves of A. conyzoides was extracted by hydrodistillation. Potato dextrose agar (PDA) was used as a culture medium. In vitro evaluation of its antifungal activity was performed on PDA medium and expressed as percentage of inhibition (PI).
Results: The extracted essential oil (with a yield of 0.63%) showed a PI of 91.63% on the strain of L. theobromae after two days of incubation. It consists of at least 23 compounds, of which seven are in the majority (abundances greater than 1.5% and represent 92.05%), namely Precocene I (38.33%), Beta-caryophyllene (26.51%), Beta-sesquiphellandrene (8.63%), Beta-cubebene (7.91%), Alpha-muurolene (4.95%), 1.5.9.9-Tetramethyl-1.4.7-cycloundecatriene (3.04%), Cis-beta-farnesene (2.99%). The hydrocarbon sesquiterpenes are the most frequent compounds (58.95%).
Discussion: Compared to the A. conyzoides saponins the PI obtained from the essential oil is higher. The essential oil chemotype obtained from the leaves of A. conyzoides is of the Precocene I type, similar to the oils from the stems and flowers of the same plant in West Africa.
Conclusion: The essential oil of A. conyzoides has a very high inhibitory power on L. theobromae. It mainly contains the Precocene and the hydrocarbon sesquiterpenes. Assessment of the antifungal activity of each separate molecule should be considered.
Final Health and Environmental Risk Assessment of Genetically Modified Soybean A5547-127
Authors: Andreassen Åshild Kristin , Bakke Anne Marie , Dahl Knut Kelkås , Dalen Knut Thomas , Finne Merethe Aasmo , Mikalsen Arne , Sanden Monica , Sipinen Ville Erling , Vikse Rose , Brandtzæg Per , Junttila Olavi , Meadow Richard , Nielsen Kåre Magnus , Sorteberg Hilde-Gunn Opsahl 
Published: March 2021

Soybean A5547-127 expresses the phosphinothricin - N - acetyltransferase (pat) gene from the soil bacterium Streptomyces viridochromogenes. The encoded PAT protein confers tolerance to the active herbicidal substance glufosinate-ammonium. Bioinformatics analyses of the inserted DNA and flanking sequences in soybean A5547-127 have not indicated a potential production of putative harmful proteins or polypeptides caused by the genetic modification. Genomic stability of the functional insert and consistent expression of the pat gene have been shown over several generations of soybean A5547-127. With the exception of the intended changes caused by the trans-genetically introduced trait, data from field trials performed in the USA show that soybean A5547-127 is compositionally, morphologically and agronomically equivalent to its conventional counterpart and other commercial soybean varieties. A repeated dose toxicity study with rats and a nutritional assessment trial with broilers have not revealed adverse effects of soybean A5547-127. These studies indicate that soybean A5547-127 is nutritionally equivalent to and as safe as conventional soybean varieties. The PAT protein produced in soybean A5547-127 does not show sequence resemblance to known toxins or IgE-dependent allergens, nor has it been reported to cause IgE-mediated allergic reactions. Soybean is not cultivated in Norway, and there are no crosscompatible wild or weedy relatives of soybean in Europe.

Based on current knowledge the VKM GMO Panel concludes that with the intended usage, there are no discernible safety concerns associated with soybean A5547-127 regarding human or animal health or to the environment in Norway.
Final Health and Environmental Risk Assessment of Genetically Modified Soybean MON 89788
Authors: Andreassen Åshild Kristin , Bakke Anne Marie , Dahl Knut Kelkås , Dalen Knut Thomas , Finne Merethe Aasmo , Mikalsen Arne , Sanden Monica , Sipinen Ville Erling , Vikse Rose , Brandtzæg Per , Junttila Olavi , Meadow Richard , Nielsen Kåre Magnus , Sorteberg Hilde-Gunn Opsahl 
Published: March 2021

Soybean MON 89788 expresses the cp4 epsps gene from the plant pathogenic bacterium Agrobacterium tumefaciens (Rhizobium radiobacter) sp. strain CP4. The encoded enzyme 5enolpyruvylshikimate-3-phosphate synthase (CP4 EPSPS) protein confers tolerance to the active herbicidal substance glyphosate. Updated bioinformatics analyses of the inserted DNA and flanking sequences in soybean MON 89788 have not indicated a potential production of putative harmful proteins or polypeptides caused by the genetic modification. Genomic stability of the functional insert and consistent expression of the cp4 epsps gene, have been shown over several generations of soybean MON 89788. With the exception of the intended changes caused by the trans-genetically introduced trait, data from several field trials performed in USA and Argentina show that soybean MON 89788 is compositionally, morphologically and agronomically equivalent to its conventional counterpart and other commercial soybean varieties. A sub-chronic feeding study with rats, as well as a nutritional assessment trial with broilers has not revealed adverse effects of soybean MON 89788. These studies indicate that soybean MON 89788 is nutritionally equivalent to, and as safe as conventional soybean varieties. The CP4 EPSPS protein produced in soybean MON 89788 does not show sequence resemblance to known toxins or IgE-dependent allergens, nor has it been reported to cause IgE-mediated allergic reactions. Soybean is not cultivated in Norway, and there are no cross-compatible wild or weedy relatives of soybean in Europe.

Based on current knowledge, the VKM GMO Panel concludes that with the intended usage, there are no discernible safety concerns associated with soybean MON 89788 regarding human or animal health or to the environment in Norway.
Autoregressive Modeling and Forecasts of Degema Monthly Allocation: Buy’s-Ballot and Bartlett’s Transformation
Authors: AfeyaIbibo Herbert, , Emmanuel Biu, Oyinebifun , Dennis Enegesele, , Allen Wokoma, Dagogo Samuel 
Published: March 2021

The paper focused on Autoregressive modeling and forecasts of Degema Local Government Council Monthly Allocation (DLGCMA) in River State, Nigeria. The Buys-Ballot table and Bartlett’s Transformation method were adopted to identify the trend pattern and to determine the best transformation for the series. The logarithmic transformation was adjudged to be the best and was applied to stabilize the variance. Identification of the trend and stationary for the data set was done and the DLGCMA series showed a linear trend that was non-stationary. The stationarity of the DLGCMA series was obtained after the first difference. The ARIMA models were fitted to the series base on the behaviour of autocorrelation function (ACF) and partial autocorrelation function (PACF). Finally, the model selection criteria called Akaike information criterion was used to determine the best model among the predicted models. The AR(3,1,0) model ( Xt = 0.56Xt-1 + 0.17Xt-2 + 0.64Xt-3 - 0.37Xt-4 + et) was considered to be the best model because it has the least value of the Akaike information criterion (AIC). Hence, the forecasts for the next allocation of twenty-four (24) months ahead were determined.