bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of COVID-19 pandemic on pediatric cardiac services in India
Authors: Choubey Mrigank , Ramakrishnan Sivasubramanian , Sachdeva Sakshi , Mani Kalaivani , Gangopadhyay Debasree , Sivakumar Kothandam , Kappanayil Mahesh , Jayranganath Mahimarangaiah , Koneti Nageswara Rao , Awasthy Neeraj , Bobhate Prashant , Gupta Saurabh Kumar , Azad Sushil , Dhulipudi Bhargavi , Sonawane Bhushan , Bandopadhyay Biswajit , Muthukumaran Chinnaswamy Sivaprakasam , Das Debasis , Sivalingam Devaprasath , Ramamurthy Harpanahalli Ravi , Nayak Hemant Kumar , Mishra Jayashree , Muthusamy Kalyanasundaram , Chakrabarti Manisha , Islam Nurul , Mahawar Prashant , Shah Prashant , Rajan Saileela , Remadevi Kavasseri Subramaniaiyer , Abqari Shaad , Chaudhary Shiv Kumar , Kasturi Soumya , Kumar Raghavannair Suresh , Saxena Anita , Iyer Krishna Subramony , Sharma Rajesh , Kumar Raman Krishna , Radhakrishnan Sitaraman , Kothari Shyam Sunder , Kulkarni Snehal , Rao Suresh G 
Published: August 2021

Background :
COVID-19 pandemic has disrupted pediatric cardiac services across the globe. Limited data are available on the impact of COVID.19 on pediatric cardiac care in India.

Aims :
The aims are to study the impact of COVID-19 pandemic on the care of children with heart disease in India in terms of number of outpatient visits, hospitalizations, catheter-based interventions, and cardiac surgeries.

Settings and Design :
This is a retrospective, multicentric, observational study.

Methods :
We collected monthly data on the number and characteristics of outpatient visits, hospitalizations, catheter-based interventions, and cardiac surgeries and major hospital statistics, over a period of 5 months (April to August 2020), which coincided with the first wave of COVID-19 pandemic in India and compared it with data from the corresponding months in 2019.

Results :
The outpatient visits across the 24 participating pediatric cardiac centers decreased by 74.5% in 2020 (n = 13,878) as compared to the corresponding period in 2019 (n = 54,213). The reduction in the number of hospitalizations, cardiac surgeries, and catheterization procedures was 66.8%, 73.0%, and 74.3%, respectively. The reduction in hospitalization was relatively less pronounced among neonates as compared to infants/children (47.6% vs. 70.1% reduction) and for emergency surgeries as compared to elective indications (27.8% vs. 79.2%). The overall in-hospital mortality was higher in 2020 (8.1%) as compared to 2019 (4.8%), with a higher postoperative mortality (9.1% vs. 4.3%).

Conclusions :
The current COVID-19 pandemic significantly impacted the delivery of pediatric cardiac care across India with two-third reduction in hospitalizations and cardiac surgeries. In an already resource-constrained environment, the impact of such a massive reduction in the number of surgeries could be significant over the coming years. These findings may prove useful in formulating strategy to manage subsequent waves of ongoing COVID-19 pandemic.
The influence of renal ischemia-reperfusion injury on remote organs
Authors: Azarkish Fariba , Armin Fakhri , Parvar Ali Atash Ab , Dehghani Aghdas 
Published: August 2021

INTRODUCTION:
Brain tissue was adversely affected by renal ischemia-reperfusion injury (renal IRI) in several studies. Moreover, we are awareness that kidney diseases are gender dependent, but there is not enough evidence of the impact of gender on renal IRI-induced brain injury. Hence, this study was designed to investigate gender differences in renal IRI-induced brain tissue injury in adult rats.

MATERIALS AND METHODS:
Forty Wistar rats (four groups) include two main groups (20 male and 20 female). Each of them was divided into two subgroups including 1 and 2: male and female sham-operated groups and 3and 4: male and female ischemia (ISC) groups were exposed to renal ischemia for 45 min and then 24 h reperfusion (male and female ISC 24 h). Sham groups were exposed to surgery without ischemia process. After reperfusion time, blood samples were obtained for the renal function measurements. The kidney and brain were removed and were fixed in a 10% formalin solution for pathological assessment. The left kidney was used to measure malondialdehyde (MDA) and nitrite.

RESULTS:
Renal IRI increased significantly levels of creatinine, blood urea nitrogen, kidney weight, and damage score in both genders (P < 0.05). Furthermore, brain injuries were significantly higher following 24 h of reperfusion in male and female groups. Serum nitrite level and MDA concentration of female rats decreased significantly in ISC 24 h group (P < 0.05) but not in male rats.

CONCLUSION:
The brain tissue of both genders, male and female, is affected by renal IRI as a remote organ. Female sex hormones may indicate a protective role against IR by the nitric oxide pathway and antioxidant signaling.
7-geranyloxycoumarin enhanced radiotherapy effects on human gastric adenocarcinoma cells
Authors: Movaffagh Jebraeel , Salari Hamide , Merajifar Elahe , hosseinian Hamid Gholam , Shahroodi Azadeh , Iranshahi Mehrdad , Rassouli Fatemeh B. 
Published: August 2021

ABSTRACT

Background:
Gastric adenocarcinoma (GA) is a serious malignancy with growing incidence and mortality rate worldwide. The objective of the present study was to determine whether 7-geranyloxycoumarin, a natural monoterpene coumarin, could induce anticancer effects, in single use and/or in combination with anticancer drugs and ionizing radiation, on GA cells.

Materials and Methods:
7-geranyloxycoumarin was synthesized by a reaction between 7-hydroxycoumarin and transgeranyl bromide. MKN45 cells were treated with 7-geranyloxycoumarin, and the viability of cells was determined by resazurin. Apoptosis was then evaluated by flow cytometric analysis using annexin V and propidium iodide, and the expression of P53 and BCL2 was analyzed by quantitative polymerase chain reaction (qPCR). Combinatorial effects of 7-geranyloxycoumarin with 5-fluorouracil (5-FU), cisplatin (CDDP), and X radiation were also evaluated.

Results:
Assessment of cell viability indicated that 7-geranyloxycoumarin induced its toxic effects in a time- and dose-dependent manner. This was confirmed by the detection of apoptotic cells, and qPCR results revealed a significant downregulation in BCL2 expression. Although combinatorial use of 7-geranyloxycoumarin + 5-FU or + CDDP did not improve cytotoxicity of anticancer drugs, significant increase in the effectiveness of applied radiations was detected upon pretreatment with 7-geranyloxycoumarin.

Conclusion:
Our findings provide valuable insights into single and combinatorial effects of 7-geranyloxycoumarin on the GA cells.
PENERAPAN RESTORATIVE JUSTICE DALAM UPAYA DIVERSI TINDAK PIDANA PENCURIAN YANG DILAKUKAN OLEH ANAK
Authors: Wardana Ferdin Okta , Muhammad Danang Wahyu , Bintarto Muhammad Al Ikhwan 
Published: August 2021

ABSTRACT
The crime of theft that often occurs in society is not only committed by adults but also children. The purpose of this study is to find out the factors that cause children to commit theft, how to apply restorative justice to crimes committed by children and what the future concept will be so that the diversion process runs properly. The method used is normative juridical through a statutory approach. The legal materials consist of the 1945 Constitution, Law Number 11 of 2012 concerning the Juvenile Criminal Justice System, Secondary materials consist of books, journals related to research. The data processing technique is obtained from primary and secondary legal materials which are processed in such a way as to be used as material to be studied. The finished data analysis is carried out as an effort to find and organize systematically in order to increase understanding of the subject matter studied. The results of this study are factors that cause children to steal because of endogenous factors from within themselves besides factors from the family and the surrounding environment that can influence children to steal and the last is economic factors and mass media, in addition to the application of restorative justice for criminal acts. theft committed by children is contained in Article 7 of Law Number 11 of 2012 concerning the juvenile criminal justice system, but in the Act on the juvenile criminal justice system there are several articles that are considered harmful, therefore for the future concept that the rules are changed so that everything is fair not only the perpetrators but also all the injured parties.
Influence of Islamic Auto Financing Instruments on Financial Performance of Commercial Banks in Isiolo County Kenya
Authors: Halake Abdi Huka , Rintari Dr. Nancy , Mutea Fredrick 
Published: August 2021

Purpose: The purpose of the study was to explore the influence of Islamic auto financing instruments on financial performance of commercial banks in Isiolo County Kenya.
Methodology: This study used descriptive research design. The respondents were customer service officers and loan officers in the ten commercial banks in Isiolo County. They were be selected using census method. Data collection was done using closed-ended questionnaires and secondary data collected through analysis of report from 2017 to 2020. To ensure validity and reliability, pre-testing of questionnaires was done at Kenya Commercial Bank in Meru town. Coded data in SPSS 24.0 computer program analyzed quantitative and qualitative data using the descriptive statistics such as mean, percentage and standard deviation. Multiple regression was used to test hypothesis of the study. Tables, graphs and detailed explanations were used to present the final results of the study.
Results: Options had a statistically significant relationship with financial performance. The respondents agreed that the lending terms of Islamic automobile financing have attracted diverse clients (mean of 4.78). However, in comparison with other statements, the respondents did not tally that having sharia committee in disbursing car loans had enabled clients have confidence with the automobile loans (mean of 3.83). The R value was 0.862 and R-square of 0.743. This indicated that Islamic auto financing instruments’ level of contribution towards financial performance was 74.3%. The Durbin- Watson value was 1.969. This value lied between 0 and 2 hence indicating that there was a positive correlation between auto financing instruments and financial performance. The significance value was 0.000 which was below 0.05 hence Islamic Auto financing instruments had a significant influence of financial performance. In addition, the respondents did not tally that having sharia committee in disbursing car loans had enabled clients have confidence with the automobile loans. This proved that the confidence that clients had on auto financing, was not purely on the nature and process of administration of the financing but also due to reliability.
Unique contribution to theory, policy and practice: The study recommends that auto financing should be provided reliably by ensuring all client concerned are amicably handled by the banking staff. The various car loan officer should be trained on good customer service to as to ensure they sell well their products without necessarily losing new clients. The bank management should also diversify auto financing to cater for all categories of vehicles for expansion of their client base.
APLIKASI GEOGEBRA UNTUK MENINGKATKAN HASIL BELAJAR MATEMATIKA MATERI FUNGSI KUADRAT MELALUI MODEL PEMBELAJARAN DISCOVERY LEARNING SISWA KELAS IX-B SMPN 1 BUDURAN
Authors: DWININGRUM Rr RETNO YOSIANA HASTARI 
Published: August 2021

Penelitian ini bertujuan untuk meningkatkan hasil belajar siswa pada materi fungsi kuadrat menggunakan aplikasi Geogebra pada smartphone berbasis android melalui model discovey learning. Penelitian ini merupakan penelitian tindakan kelas terdiri dari dua siklus dengan masing- masing siklus terdiri atas 2 kali pertemuan.menggunakan empat langkah kegiatan. Dari hasil analisis diperoleh gambaran bahwa penggunaan aplikasi geogebra berbasis android dapat meningkatkan hasil belajar siswa kelas IX-B SMP Negeri 1 Buduran pada materi menggambar grafik fungsi kuadrat. Secara kuantitatif ada peningkatan hasil belajar. Sebelum dilakukan tindakan rata-rata skor siswa 71,25 dengan ketuntasan klasikal sebesar 47%. Setelah dilakukan tindakan Pada siklus 1 daya serap sebesar 76,4 dengan ketuntasan klasikal 77,7%, setelah dilakukan tindakan pada siklus II daya serap menjadi 87,66 dengan ketuntasan klasikal 91,67%. Terjadi peningkatan kualitatif dari sebelum dilakukan tindakan dan setelah dialkukan tindakan sebesar 44,67%. sehingga penggunaan aplikasi geogebra pada materi fungsi kuadrat menggunakan model discovery learning dapat meningkatkan hasil belajar siswa.
Examination regarding the tolerability of the homochord Acidum L(+)-lacticum at a dosage of sixty drops three times daily
Authors: Sonntag Dieter 
Published: August 2021

In Germany, the commission D recommends in its current dosage guidelines from March 17, 2004, that homeopathic dilutions higher than 24x will be prescribed in a daily application of five drops once. This recommendation is decisive for the German Regulatory Authority. Even though the homochord Acidum L(+)-lacticum 4x/6x/12x/30x/200x contains dilutions above 24x, it is commonly used in clinical practice for over 30 years in a dosage of 60 drops three times daily.
In order to explore the clinical safety and tolerability of Acidum L(+)-lacticum 4x/6x/12x/30x/200x at a dosage of 60 drops three times daily, as well as lower dosages, a therapist survey was designed to address the questions.
Highly experienced and licensed therapists, including general and alternative practitioners, reported their usual dosage of homochord, incidences of drug reactions, initial homeopathic aggravations as well as the diagnoses that led to the prescription of Acidum L(+)-lacticum 4x/6x/12x/30x/200x. 167 therapist responses were analyzed.
Only four therapists reported occurrences that classify as initial aggravation, (2.40 %), compared to 159 with no incidences (95.21 %). Four therapists made no statement. Nevertheless, there were no adverse drug reactions documented in the survey. Consequently, Acidum L(+)-lacticum 4x/6x/12x/30x/200x at a dosage of 60 drops three times daily or lower dosages may be construed to be clinically tolerable and safe. This evidence might lead to further re-evaluations of other homochords, and rigorous clinical trials for its safety and tolerability.
A paradigm of extreme rainfall pluvial floods in complex urban areas: the flood event of 15 July 2020 in Palermo (Italy)
Authors: Francipane Antonio , Pumo Dario , Sinagra Marco , La Loggia Goffredo , Noto Leonardo Valerio 
Published: August 2021

Abstract. In the last few years, some regions of the Mediterranean area have witnessed a progressive increase in extreme events, such as urban and flash floods, as a response to the increasingly frequent and severe extreme rainfall events, which are often exacerbated by the ever-growing urbanization. In such a context, the urban drainage systems may not be sufficient to convey the rainwater, thus increasing the risk deriving from the occurrence of such events. This study focuses on a particularly intense urban flood that occurred in
Palermo (Italy) on 15 July 2020; it represents a typical pluvial flood due
to extreme rainfall on a complex urban area that many cities have
experienced in recent years, especially in the Mediterranean region. A
conceptual hydrological model and a 2D hydraulic model, particularly
suitable for simulations in a very complex urban context, have been used to
simulate the event. Results have been qualitatively validated by means of
crowdsourced information and satellite images. The experience of Palermo, which has highlighted the urgent need for a shift in the way stormwater in urban settlements is managed, can be assumed to be a paradigm for modeling pluvial floods in complex urban areas under extreme rainfall conditions. Although the approaches and the related policies cannot be identical for all cities, the modeling framework used here to assess the impacts of the event under study and some conclusive remarks could be easily transferred to other, different urban contexts.
Trik Konselor Sebaya dalam Upaya Mencegah Perilaku Seks Pranikah di Kalangan Remaja
Authors: Muhammad Sayyid Naufal Ramadhan  , Mohammad Salehudin  , Rudy Hadi Kusuma  
Published: August 2021

Tujuan penelitian ini untuk mendeskripsikan trik konselor sebaya dalam upaya mencegah perilaku seks pranikah di kalangan remaja, penelitian ini dengan pendekatan kualitatif deskriptif memilih lokasi penelitian dan konselor sebaya yang berada di empat PIK-R (PIK-R Widiagama, PIK-R Palapa, PIK-R Mahakam Borneo dan PIK-R Pelita Hati di Kota Samarinda) wawancara digunakan untuk mengumpulkan data dengan model wawancara terstruktur kemudian di analisis dengan model miles and Huberman. Hasil penelitian pada upaya yang dilakukan beberapa trik konselor Sebaya bersama PIK-R dalam upaya mencegah perilaku seks pranikah yaitu diantaranya; 1) Trik dengan Penyuluhan oleh konselor sebaya ke lingkungan remaja dan ke sekolah-sekolah, 2) Trik dengan Penguatan PIK-R (pemberian pemahaman dan pembinaan) pemahaman kepada anggota PIK-R melalui sharing materi dan diskusi serta pembinaan kepada PIK-R yang baru dibentuk, 3) Trik dengan Sosialisasi Kepada Remaja 4). Trik dengan sosialisasi kepada orang tua 5). Trik Memanfaatkan Media Sosial dalam kampanye dan dokumentasi, dan 6). Trik Penyuluhan dan Sosialisasi. Terjun langsung ke lingkungan remaja dengan media GenRe KIT dan melakukan sosialisasi kepada orang tua remaja dan bekerjasama dengan BKR (Bina Keluarga Remaja).
Kajian Kesenjangan Pendapatan Provinsi Jambi
Authors: Daniel Prima Audia 
Published: August 2021

Penelitian ini bertujuan menganalisis pengaruh jumlah penduduk, inflasi, investasi dan pertumbuhan ekonomi terhadap kesenjangan pendapatan di Kota Jambi selama lima tahun (2007-2011). Metode yang digunakan dalam penelitian ini adalah Gini Ratio untuk kesenjangan pendapatan dan regresi berganda Durbin Watson untuk mengetahui factor-faktor yang mempengaruhi kesenjangan pendapatan.
Hasil analisis menunjukkan bahwa seluruh variabel independen berpengaruh signifikan terhadap kesenjangan pendapatan di Jawa Tengah. Dapat disimpulkan bahwa Hipotesis Kuznets berlaku dalam penelitian ini. Hal ini dapat dilihat dari hubungan positif antara pertumbuhan ekonomi dan kesenjangan pendapatan.
Strategi Pemberdayaan Usaha Mikro Kecil dan Menengah dalam Rangka Menyongsong Pasar Global
Authors: Rosmiati Rosmiati 
Published: August 2021

The era globalization has challenged business to compete produce a quality product types. Once the importance of the role of bussines especially micro, small and medium enterprises (SMEs) in producing a product, it is necessary effors and right strategies for empowering micro, small and medium enterprises (SMEs). This study aims to develop a proper strategi to maximize and develop micro, small and medium enterprises (SMEs) and area need to be known and analyzed. The method in this study is a deskriptif study of literature review study discussed the strategi of empowering micro, small and medium enterprises (SMEs). The are three (3) basic policies needed in empowering micro, small and medium enterprises (SMEs), which are (1) creating a conducive bussinessenvironment at the same time providing an evirontment that encourages the development of SMEs syistemically, independent, and sustainable, (2) creating insurance system financially to the operation of productive economic activities undertaken by SMEs and (3) provide technical assistance and managerial assistance in order to improve th e status of SME. The conclusion of this literature review provide an important means for achieving planning appropriate strategies on micro, small and medium enterprises (SMEs).
Analisis Determinan Kemiskinan di Sumatera
Authors: Mubyarto Novi 
Published: August 2021

Menggunakan data panel dari 10 provinsi untuk periode 1993-2012, penelitian ini bertujuan untuk menganalisis faktor-faktor penentu kemiskinan di Sumatera. Adapun model analisis yang digunakan pada penelitian ini adalah model regresi data panel dengan metode first difference. Hasil empiris menunjukkan bahwa pertumbuhan ekonomi di sumatera selama periode 1993-2012 tidak berpengaruh signifikan terhadap kemiskinan, tetapi peningkatan ketimpangan pendapatan meningkatkan kemiskinan di wilayah tersebut. Peningkatan indek pembangunan manusia berpengaruh signifikan terhadap menurunkan kemiskinan, Di sisi lain, variabel positif dan signifikan terkait dengan kemiskinan di Sumatera adalah tingkat inflasi dan dummy krisis. Selain itu pengangguran tidak signifikan mempengaruhi kemiskinan di Sumatera.
Analisis Hubungan Pengeluaran Pemerintah dan PDRB Pemerintah Kabupaten Merangin
Authors: Mahmud Mahmud , Nuranti Lita Dwi 
Published: August 2021

Pengeluaran Pemerintah aplikasi dari kebijakan dalam upaya peningkatan pelayanan umum dan kesejahteraan masyarakat di daerah. Oleh karena itu Pemerintah Daerah dan DPRD yang merupakan salah satu instrumen utama berupaya secara nyata dan terstruktur untuk menghasilkan APBD yang betulÃƒâ€šÃ‚Â­betul mencerminkan kebutuhan riil masyarakat di daerah sesuai dengan potensi masing-masing. Untuk melihat apakah daerah telah siap secara pansial untuk menyongsong otonomi daerah, antara lain adalah dengan melihat apakah sumber-sumber penerimaan APBD nya mampu menutup anggaran belanja daerah yang bersangkutan.
PENGARUH PERTUMBUHAN EKONOMI, PENDIDIKAN DAN PENGANGGURAN TERHADAP KEMISKINAN DI PROVINSI JAMBI
Authors: Sari Yolanda , Falianto Antony 
Published: August 2021

Permasalahan strategis di pemerintahan Provinsi Jambi tidak jauh berbeda dengan di pemerintahan pusat (problem nasional), yakni masih tingginya angka kemiskinan di Provinsi Jambi. Oleh karena itu, kemiskinan menjadi tanggung jawab bersama, terutama pemerintah sebagai penyangga proses perbaikan kehidupan masyarakat dalam sebuah pemerintahan, untuk segera mencari jalan keluar dengan merumuskan langkah-langkah yang sistematis dan strategis sebagai upaya pengentasan kemiskinan. Penelitian ini bertujuan untuk menganalisis pengaruh pertumbuhan ekonomi, pendidikan dan pengangguran terhadap kemiskinan di Provinsi Jambi baik secara parsial maupun secara simultan.
Data yang digunakan dalam penelitian ini adalah data sekunder berupa data pertumbuhan ekonomi, pendidikan, pengangguran dan kemiskinan di Provinsi Jambi pada tahun 2004-2019. Metode pengolahan data menggunakan analisis regresi linier berganda.
Hasil analisis untuk persamaan regresi linier berganda adalah sebagai berikut: LogY = 7,800 - 0,219LogX1 ÃƒÂ¢Ã¢â€šÂ¬Ã¢â‚¬Å“ 0,406LogX2 + 0,036LogX3 + e dengan X1 Pendidikan, X2 Pertumbuhan Ekonomi, X3 Pengangguran dan Y adalah Kemiskinan di Provinsi Jambi. Kemudian dari hasil analisis diperoleh hasil bahwa X1, X2 dan X3 berpengaruh signifikan terhadap Y. Berdasarkan hasil penelitian ini dapat disimpulkan beberapa hal sebagai berikut: 1) variabel pertumbuhan ekonomi (X1) dan pendidikan (X2) berpengaruh negatif dan signifikan terhadap Kemiskinan (Y). Dan variabel pengagguran (X3) berpengaruh positif dan signifikan terhadap kemiskinan (Y) di Provinsi Jambi Tahun 2004-2019. 2) Secara simultan diperoleh bahwa Pertumbuhan Ekonomi (X1), Pendidikan (X2) Dan Pengangguran (X3) mempunyai pengaruh yang positif dan signifikan terhadap Kemiskinan (Y) di Provinsi Jambi periode 2004-2019.