bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE CONSTRUCTION OF MODERATION IN RELIGIOUS EDUCATION BASED ON LOCAL WISDOM
Authors: Sugianto Hendi , Muhaemin Muhaemin , Karim Abdul Rahim 
Published: December 2024

This research uses qualitative research methods to describe the construction of religious moderation based on local wisdom at the Pesantren Harisul Khairat. Data collection techniques in this study were carried out through observation with the type of participant observation, interviews with semi-structured interviews, and documentation studies. The data obtained was then analyzed using an interactive analysis model following to Miles and Huberman, namely data condensation, data presentation, and verification or conclusion drawing. The results showed that the construction of religious moderation education in Pesantren Khairaat applies the charismatic approach of the kyai and the rules of the Pesantren in shaping the character, discipline, and spirituality of the students at the externalization stage. The objectivation process occurs through interactions between students and their understanding of religious moderation that is institutionalized in daily practice, becoming an objective reality that is internalized by students. In the internalization stage, the Pesantren maintains values and traditions through socio-cultural adaptation, and students develop a subjective understanding of religious moderation education.
GmARF15 Enhances the Resistance of Soybean to Phytophthora sojae by Promoting GmPT10d Expression in Response to Salicylic Acid Signalling
Authors: Huo Yuhan , Chen Haiyuan , Zhang Zhuo , Song Yang , Liu Siyan , Wang Piwu , Fan Sujie 
Published: December 2024

Phytophthora root and stem rot caused by Phytophthora sojae (P. sojae) is a globally prevalent oomycete disease. The use of resistant cultivars is an effective and environmentally friendly strategy to manage this disease. It is important to understand the molecular mechanisms underlying the response of Glycine max (soybean) to P. sojae infection. In this study, we demonstrated that an isoflavonoid-specific prenyltransferase gene (GmPT10d, Glyma.10G070300) was significantly upregulated in the soybean cultivar Williams 82 with high resistance to P. sojae infection. Transgenic soybean seedlings overexpressing GmPT10d exhibited enhanced resistance to P. sojae, and those subjected to RNA interference showed increased susceptibility to the pathogen. Yeast-one-hybrid and electrophoretic mobility shift assays revealed that GmARF15 could directly bind to the promoter of GmPT10d. Further analysis of the GmARF15 function showed that transgenic soybean seedlings overexpressing GmARF15 also exhibited enhanced resistance to P. sojae. Transactivation assay, luciferase assay, and qPCR analysis showed that GmARF15 could promote the expression of GmPT10d. Further analysis indicated that elevated salicylic acid levels were associated with increased expression of GmARF15 and GmPT10d. Taken together, these findings reveal a regulatory mechanism by which GmARF15 enhances soybean resistance to P. sojae, potentially by promoting the expression of GmPT10d through the salicylic acid signaling pathway.
Endophytic Fungi of Calea pinnatifida (Asteraceae): Dereplication of Crude Extracts, Antimicrobial Properties, and Identification of New Tetronic Acid Derivative Produced by Hypomontagnella barbarensis
Authors: Barna Bianca , Caldas Lhaís Araújo , Monteiro Jackson , dos Santos Augusto Leonardo , Pascon Renata Castiglioni , Vallim Marcelo Afonso , Ferreira Marcelo José Pena , Gonçalves Sarah Santos , dos Santos Glaucia Queiroz , Rodrigues Anderson Messias , de Carvalho Jamile Ambrósio , de Vasconcellos Suzan Pantaroto , Sartorelli Patricia 
Published: December 2024

Endophytic fungi are increasingly being recognized for their diverse metabolites that may exhibit antimicrobial properties. In our study, we isolated seven endophytic fungal strains from Calea pinnatifida, which were identified as Hypomontagnella barbarensis, Neopestalotiopsis clavispora, Nigrospora sacchari-officinarum, Annulohypoxylon moriforme, Colletotrichum siamense, and Colletotrichum karstii (with two isolates from the same species). Furthermore, the antimicrobial activity of the extracts was assessed, revealing that the extract from Hypomontagnella barbarensis demonstrated activity against Staphylococcus aureus. Further investigation of secondary metabolites, employing UHPLC-HR-ESI-MS/MS in combination with molecular networking, facilitated annotation of the nine compounds. Of these, five were identified based on matches with the GNPS spectral library, and four were predicted based on the molecular network. Notably, from the extract of Hypomontagnella barbarensis, two pairs of diastereoisomeric acyl-tetronic acid derivatives were isolated and characterized using MS and NMR spectroscopy. This study highlights the potential of endophytic fungi as a valuable source of novel antimicrobial agents.
Development of a Comprehensive Approach to Quality Control of Dermorphin Derivative—Representative of Synthetic Opioid Peptides with Non-Narcotic Type of Analgesia
Authors: Sukhanova Vasilisa A. , Uspenskaya Elena V. , Ainaz Safdari , Quynh Hoang Thi Ngoc , Timofeev Aleksey A. 
Published: December 2024

Peptides occupy a significant share of the pharmaceutical market and are among the top-200 selling drugs in the group of non-insulin drugs with analgesic, antibacterial and cardiovascular effects. The aim of this work is to develop a comprehensive analytical approach for quality control of novel synthetic peptides with non-narcotic types of analgesia and to provide docking simulations of dermorphin complex formation at the μ-opioid receptor (MOR) binding site. The materials and methods used include the pharmaceutical substance dermorphin tetrapeptide (DMTP) (tyrosyl-D-arginyl-phenylalanyl-glycinamide); Fourier transform infrared spectroscopy (FT-IR); static and dynamic laser light scattering (DLS, LALLS); scanning optical microscopy (SEM); X-ray fluorescence elements analysis; polarimetry for optical activity determining; and Spirotox method for sample biotesting. FT-IR-Spectra indicated specific amino acid chemical groups in the tetrapeptide sequence at 3300–2700 cm−1, 1670 cm−1. UV-absorption spectra of aqueous solutions of dermorphin tetrapeptide showed an absorption maximum at 275 nm, which is in good agreement with the presented spectrum of the bovine serum albumin (BSA) standard; the Pearson’s r of calibration line “A-C%” in 0.0125% to 0.0500% concentration range is 0.999; and the calculated specific extinction value E1cm 1% = 18.38 ± 0.23. Of the 11 elements detected by X-rays, the elements copper (Cu) and cobalt (Co) have the highest X-ray intensity. Dispersion characteristics of dermorphin solutions were studied in the submicron and micron range. Conglomerates and druzes were detected by SEM, ranging in size from 2 µm to 100 µm. The specific optical activity index was calculated αD20 = +36.18 ± 2.04 [°·mL·g−1·dm−1], according to Biot’s Law. Additionally, the orientation and conformation of the dermorphin molecule in the active binding site of the 8E0G receptor were predicted using molecular modeling, revealing that the contact area affects the key amino acid residue arginine (ARG 182). This comprehensive approach to analytical methods for qualitative and quantitative analysis of dermorphin tetrapeptide can be applied in pharmacies to enhance the understanding of its biological activity and aid in the development of regulatory documentation for a new, non-narcotic analgesic based on the dermorphin tetrapeptide.
Perspective of The Vatican’s Peace Diplomacy in the Region Dispute
Authors: Korniawan Rostamaji 
Published: December 2024

The peace process of regional dispute is handled with various processes and the sides who are concerned about the conflict, including the Vatican’s aid by using its peace diplomacy. The Vatican knew that mitigating the regional dispute had to face several challenges. However, the process and efforts to mitigate many areas of regional dispute are still the Vatican’s belief that peace becomes part of human rights and universal values. By observing methods based on the issue of regional dispute, this paper purposed to analyze the Vatican’s peace diplomacy during Pope Francis’ leadership. The analysis finds that mitigating regional disputes using a religious approach and the role of the Catholic church and Supreme Pontiff can effectively rehabilitate the conflict and finally turn into expected results based on negotiation. However, the Ukraine-Rusia dispute still creates brain-drain for the Vatican, including several regional disputes in Asian territory. The unresolved dispute indicates that the religious approach still needs aid from the other side. Therefore, the Pope, the Catholic church, and the rest of the world are still using proper diplomacy and strategy to fulfill the goal of the future of global peace.
Роль морфологического исследования в дифференциальной диагностике туберкулеза и саркоидоза легких: литературный обзор
Authors: Дюсьмикеева М.И. , Атаманова О.Г. 
Published: December 2024

Интерес к проблеме гранулематозных болезней легких в последние годы обусловлен ростом распространенности этих заболеваний и трудностью их диагностики. Диагностические ошибки у данных пациентов составляют 75–80%. До сих пор не существует универсального алгоритма диагностики подобных заболеваний. Совершенствование клинико-морфологической диагностики гранулематозных заболеваний легких остается актуальной проблемой и имеет большое практическое значение. В настоящее время среди гранулематозных болезней наиболее часто встречаются туберкулез и саркоидоз. Дифференциальная диагностика саркоидоза и туберкулеза, оставаясь одной из сложнейших проблем пульмонологии, находит существенную опору в результатах морфологического исследования. Однако патологоанатомическое заключение не может идти далее констатации факта, что при гистологическом исследовании обнаруживается гранулематозная реакция. Дифференциальная диагностика туберкулеза и саркоидоза требует мультидисциплинарного подхода. Решающее значение в дифференциальной диагностике туберкулеза и саркоидоза имеют бактериоскопическое, иммуногистохимическое и молекулярно-генетическое исследования.
Interest in the problem of granulomatous lung diseases in recent years is due to the increasing prevalence of these diseases and the difficulty of diagnosing them. Diagnostic errors in these patients are 75–80%. There is still no universal algorithm for diagnosing such diseases. Improving the clinical and morphological diagnosis of granulomatous lung diseases remains an urgent problem and is of great practical importance. In recent years, the most common granulomatous diseases are tuberculosis and sarcoidosis. Differential diagnosis of sarcoidosis and tuberculosis, remaining one of the most difficult problems of pulmonology, finds significant support in the results of morphological research. However, the pathological conclusion cannot go further than stating that histological examination reveals a granulomatous reaction. Differential diagnosis of tuberculosis and sarcoidosis requires a multidisciplinary approach. Bacterioscopic, immunohistochemical and molecular genetic studies are of decisive importance in the differential diagnosis of tuberculosis and sarcoidosis.
Физиотерапия в лечении воспалительных заболеваний органов малого таза
Authors: Савицкая В.М. , Лобачевская О.С. , Акулич Н.С. 
Published: December 2024

Данная статья посвящена актуальной проблеме лечения воспалительных заболеваний женских половых органов. В работе рассматриваются комплексные схемы лечения воспалительных заболеваний с учетом патогенеза воспаления, влияние методов физиотерапии на отдаленные результаты лечения. Также в статье описаны различные варианты физиотерапевтического лечения воспалительных заболеваний.
This article is devoted to the current problem of treatment of inflammatory diseases of the female genital organs. The work examines complex treatment regimens for inflammatory diseases, taking into account the pathogenesis of inflammation, and the influence of physiotherapy methods on long-term treatment results. The article also describes various options for physiotherapeutic treatment of inflammatory diseases.
Sınıf Öğretmenlerinin Okuma Becerisini Oluşturan Bilişsel Bileşenlere Yönelik Farkındalıklarının Artırılması: Bir Karma Yöntem Eylem Araştırması
Authors: Gök Seçkin , Yıldırım Kasım 
Published: December 2024

Çalışmanın amacı sınıf öğretmenlerinin okumayı oluşturan bilişsel becerilere yönelik farkındalıklarını artırmak ve farkındalıklarının sınıf içi öğretme ortamına yansımalarını ortaya koymaktır. Çalışma, karma yöntem eylem araştırması olarak desenlenmiş ve yürütülmüştür. Çalışmanın keşfetme aşamasında öğretmenlerin okumayı oluşturan bilişsel becerilere yönelik farkındalıkları odak grup görüşmeleri yoluyla ortaya çıkarılmıştır. Ardından öğretmenlerin okumaya ilişkin bilgilerinin yetersizliğinden hareketle bir müdahale eğitim programı oluşturulmuştur. Çalışmanın değerlendirme aşamasında uygulanan müdahale eğitiminin etkililiği tespit edilmiştir. Araştırmanın izleme aşamasında ise eğitim programı ve takip çalışmalarının sınıf içi öğretim ortamına yansıması yine odak grup görüşmeleri yoluyla ortaya konulmuştur. Çalışmanın keşfetme aşaması katılımcılarını 14 gönüllü sınıf öğretmeni oluşturmuştur. Değerlendirme aşaması katılımcılarını eğitim programına katılan 30 gönüllü sınıf öğretmeni oluştururken izleme aşaması katılımcılarını eğitim programına katılan öğretmenlerden 12 gönüllü sınıf öğretmeni oluşturmuştur. Çalışmada veri toplama aracı olarak araştırmacılar tarafından geliştirilen bilgi testi ve görüşme formları kullanılmıştır. Çalışmanın keşfetme ve izleme aşamalarından elde edilen veriler içerik analizi yöntemiyle çözümlenmiştir. Değerlendirme aşamasından elde edilen verilerin analizinde betimsel istatistiklerin yanında eşli gruplar t-testinden yararlanılmıştır. Araştırmada, sınıf öğretmenlerinin okumayı oluşturan bilişsel bileşenlere ilişkin bilgi eksiklikleri ortaya konulmuş, gerçekleştirilen müdahale eğitimiyle bu eksiklikler giderilmiş ve müdahale eğitimi yoluyla elde ettikleri bilgileri sınıf içi öğretim ortamına yansıttıkları görülmüştür.
Application of Waterfall Method in Sales System using Laravel 10 Framework in Bella Grocery Store
Authors: Fernanda Bagus Dwi Prastyo  , Abdul Rohman  
Published: December 2024

Bella grocery store does not yet have a cashier system that can record transactions and manage stock items so it faces various challenges in managing stock items and recording transactions. Our research aimed to build a web-based sales system at the store using the waterfall method and the Laravel 10 framework. To identify the main needs including stock management, transaction recording and financial reports we collect data through direct interviews and observations. The system is designed with the waterfall method starting from requirements analysis, system design, and implementation to testing. The results of the implementation of this system can help manage stock items, and record transactions and financial reports at the store. The results of black box testing ensure that all features function properly. with this system, Bella grocery stores can manage stores more accurately and organized.
СУЧАСНІ ПІДХОДИ ДО ФОРМУВАННЯ ТА РЕАЛІЗАЦІЇ ДЕРЖАВНОЇ ПОЛІТИКИ В КОНТЕКСТІ ВІДНОВЛЕННЯ УКРАЇНИ ТА ЇЇ СТІЙКОГО РОЗВИТКУ: ВРАХУВАННЯ ІНСАЙТІВ НІМЕЧЧИНИ (англ)
Authors: Колісніченко Наталя 
Published: December 2024

У статті вивчається досвід Німеччини щодо післявоєнної відбудови у контексті його застосування до процесів відновлення України в рамках формування та реалізації державної політики. Досліджуються такі сфери, як-от: розвиток інфраструктури; комунікація із зацікавленими сторонами; міжнародна допомога. Аналізуються приклади успішної післявоєнної відбудови суспільств після руйнівних конфліктів. Актуалізується значення цього досвіду для України, яка потребує вилучення уроків минулого у своєму майбутньому, щоб досягти успіху. Розглядаються приклади успішної реконструкції міст після війни в Німеччині, де руйнування міст розглядали як своєрідну можливість для впровадження нової, більш прогресивної архітектури. Акцент у новому плануванні робився на покращенні умов для проживання населення, на будівництві неокласичних адміністративно-культурних комплексів тощо. Загалом, післявоєнна відбудова Німеччини (її східної частини) мала такі важливі моменти, як: будівництво палаців, мегаплощ для демонстрацій, разом з тим здійснювалася активна робота з відновлення інфраструктури та житла; активне будівництво та благоустрій муніципального простору. Досвід Німеччини продемонстрував, що те, що відбувається після війни, може бути важливішим за саму війну. Розглядаються позитиви комунікаційної політики, співпраця зі стейкхолдерами. З досвіду Німеччини зроблено висновок, що відновлення країни залежить від: державних інвестицій (в різноманітні сфери з високим рівнем зайнятості, від сільського господарства до малого бізнесу); розвитку і просування «соціальної ринкової економіки», концепції, яка сприяла вільному ринковому капіталізму тощо. На сьогодні державна економіка України періоду воєнного стану надзвичайно залежить від зовнішньої підтримки. Значна частина поточної допомоги, а також майбутні фінансові обіцянки надходять не як гранти, а як позики.
ОСОБИСТІСНІ ДИСПОЗИЦІЇ МАЙБУТНІХ ПСИХОЛОГІВ ЯК ДЕТЕРМІНАНТИ ГОТОВНОСТІ ДО РОБОТИ ЗІ СХИЛЬНИМИ ДО ДЕВІАНТНОЇ ПОВЕДІНКИ ПІДЛІТКАМИ
Authors: Луцик Галина 
Published: December 2024

The article analyses the personal dispositions of future psychologists in the context of preparation for work with adolescents prone to deviant behaviour. Based on the analysis of theoretical sources, it is established that the personal qualities of future specialists significantly affect the formation of readiness to work in the chosen speciality and determine the success of professional activity.
Factorization of personal characteristics of the research participants made it possible to obtain a factor model of personal dispositions of future psychologists. The complex of integral dispositions (factors) of future psychologists, which includes “personal self-control”, “personal openness”, “personal self-acceptance”, “personal independence”, has been determined.
We believe that the structural model of future psychologists' readiness to work with adolescents prone to deviant behaviour is determined by a set of integral structural components (factors) – “creative and practical”, “cognitive”, “value and motivational”, and “regulatory”.
It was found that the dispositions of “personal openness” and “personal self-acceptance” were verified as predictive personal determinants of the formation of the “creative and practical” component of future psychologists' readiness to work with adolescents prone to deviant behaviour, the “cognitive” component – the dispositions of “personal self-control” and “personal independence”, the “value and motivational” component – the disposition of “personal openness”, the “regulatory” component – the disposition of “personal self-control”.
It has been proved that future psychologists' readiness to work with adolescents prone to deviant behaviour is a systemic personal education that is formed during studies in a higher education institution, represented by an appropriate level of development of their mental, emotional and volitional, value and motivational, and operational personal spheres, each structural component of which is determined by a specific system of prognostic personal determinants
The European Union energy transition in the context of the Fit for 55 and REPowerEU strategies
Authors: Klecha-Tylec Karolina , Pach-Gurgul Agnieszka , Ulbrych Marta 
Published: December 2024

RESEARCH OBJECTIVE: The aim is to present the conditions, assumptions and concept of the Fit for 55 and REPower EU strategies, and subsequently evaluate their progress.
THE PROBLEM AND RESEARCH METHODS: The fundamental justification for the EU’s energy transformation, as the leader in this area so far, was climate protection. After Russia’s invasion of Ukraine, the urgent need for increased energy security turned out to be. In seeking answers to the possibilities of implementing both tasks, the study used a number of research methods, including primarily critical literature analysis and descriptive statistics methods.
THE PROCESS OF ARGUMENTATION: Firstly, the essence of the modern energy transition and a review of the literature in this field are presented. Then, an attempt is made to address the dilemma: the EU energy transformation – progress or regression? The next part presents the importance of Fit for 55 and REPowerEU. Finally, the key energy figures and analyzed strategies progress were presented.
THE RESEARCH RESULTS: In response to the events in Ukraine, the EU launched the REPowerEU plan to reduce dependence on Russian fuels by cutting energy consumption, diversifying supplies, and boosting clean energy production. It accelerates the Fit for 55 plan, which aims to cut CO2 emissions by 55% by 2030 and reach net zero by 2050. While the plan originally included a gradual shift from Russian hydrocarbons, the invasion has prompted the EU to fast-track decarbonization, though short-term energy security concerns may slow the energy transition.
CONCLUSION, INNOVATIONS, AND RECOMMENDATIONS: The analysis carried out made it possible to conclude that the war in Ukraine has not caused a retreat from the green energy transition, on the contrary, it has further motivated the EU to take several actions including decarbonization as defined in the Fit for 55 and REPowerEU strategies.
Time Trend Analysis of Ambient Air Quality and Increased ISPA in Kendari City
Authors: Hidayat Muh. Taufik , Jayadipraja Erwin Azizi , Asrullah Muhammad , Astawa Kadek Wiana 
Published: December 2024

Acute Respiratory Infections (ARI) kill around 4 million people every year. Infants, children, and the elderly are most at risk. Each year, more than 2 million children under five years old die from ISPA. This research aims to describe the trend of ARI sufferers among toddlers in Kendari City for 2021-2023. The type and design of the research is descriptive. The population and sample (total sampling) are all toddlers suffering from ARI in Kendari City in 2021-2023, namely 23,508 toddlers. The research results show that the number of ARI cases in toddlers in Kendari City continues to increase every year. In 2021, it will be 24%; in 2022, it will be 36.2%; and in 2023, it will be 39.7%. During the 2021-2023 period, the number of male toddlers suffering from ARI was 52.7% greater than that of females, 47.2%. The number of ARI cases in the <1 year age group was 25.2%, and in the 1-<5 year age group was 74.7%. The health center with the highest number of ARI sufferers is the Puwatu Health Centre, with 15.5% of cases, and the lowest is the Jatiraya Health Centre, with 0.9% of cases. This research concludes that there is an increasing trend in the number of toddlers suffering from ARI in Kendari City for 2021-2023. Community health centers should provide education through posyandu activities regarding the dangers of ARI in toddlers and efforts to overcome them.