bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geology differentiation by applying unsupervised machine learning to multiple independent geophysical inversions
Authors: Melo Aline , Li Yaoguo 
Published: August 2021

SUMMARYEffective quantitative methods for integrating multiple inverted physical property models are necessary to increase the value of information and advance interpretation further to produce interpretable geology models through geology differentiation. Geology differentiation is challenging in greenfield exploration areas where specific a priori geological information is scarce. The main problem is to identify geological units quantitatively with appropriate 3-D integration of these models. The integration of multiple sources of information has been conducted with different unsupervised machine learning methods (e.g. clustering), which can identify relationships in the data in the absence of training information. For this reason, we investigate the performance of five different clustering methods on the identification of the geological units using inverted susceptibility, density, and conductivity models that image a synthetic geological model. We show that the correlation-based clustering yields the best results for the geology differentiation among those investigated by identifying the correlation between physical properties diagnostic of each unit. The result of the differentiation is a quasi-geology model, which is a model that represents the geology with inferred geological units and their spatial distribution. The resulting integrated quasi-geology model demonstrates that individually inverted models with minimal constraints have sufficient information to jointly identify different geological units.
Placebo Response and Its Predictors in Attention Deficit Hyperactivity Disorder: A Meta-Analysis and Comparison of Meta-Regression and MetaForest
Authors: Castells Xavier , Saez Marc , Barcheni Maghie , Cunill Ruth , Serrano Domènec , López Beatriz , van Lissa Caspar J 
Published: August 2021

Abstract

Background
High placebo response in attention deficit hyperactivity disorder (ADHD) can reduce medication–placebo differences, jeopardizing the development of new medicines. This research aims to (1) determine placebo response in ADHD, (2) compare the accuracy of meta-regression and MetaForest in predicting placebo response, and (3) determine the covariates associated with placebo response.

Methods
A systematic review with meta-analysis of randomized, placebo-controlled clinical trial investigating pharmacological interventions for ADHD was performed. Placebo response was defined as the change from baseline in ADHD symptom severity assessed according to the 18-item, clinician-rated, DSM-based rating scale. The effect of study design–, intervention–, and patient–related covariates in predicting placebo response was studied by means of meta-regression and MetaForest.

Results
Ninety-four studies including 6614 patients randomized to placebo were analyzed. Overall, placebo response was −8.9 points, representing a 23.1% reduction in the severity of ADHD symptoms. Cross-validated accuracy metrics for meta-regression were R2 = 0.0012 and root mean squared error = 3.3219 for meta-regression and 0.0382 and 3.2599 for MetaForest. Placebo response among ADHD patients increased by 63% between 2001 and 2020 and was larger in the United States than in other regions of the world.

Conclusions
Strong placebo response was found in ADHD patients. Both meta-regression and MetaForest showed poor performance in predicting placebo response. ADHD symptom improvement with placebo has markedly increased over the last 2 decades and is greater in the United States than the rest of the world.
Uniform Potential Density for Rational Points on Algebraic Groups and Elliptic K3 Surfaces
Authors: Lai Kuan-Wen , Nakahara Masahiro 
Published: August 2021

Abstract
A collection of varieties satisfies uniform potential density if each of them contains a dense subset of rational points after extending its ground field by a bounded degree. In this paper, we prove that uniform potential density holds for connected algebraic groups of a fixed dimension over fields of characteristic zero as well as elliptic K3 surfaces over number fields.
Off-Diagonal Estimates for Bi-Commutators
Authors: Airta Emil , Hytönen Tuomas , Li Kangwei , Martikainen Henri , Oikari Tuomas 
Published: August 2021

Abstract
We study the bi-commutators $[T_1, [b, T_2]]$ of pointwise multiplication and Calderón–Zygmund operators and characterize their $L^{p_1}L^{p_2} \to L^{q_1}L^{q_2}$ boundedness for several off-diagonal regimes of the mixed-norm integrability exponents $(p_1,p_2)\neq (q_1,q_2)$. The strategy is based on a bi-parameter version of the recent approximate weak factorization method.
Pharmacokinetics of vaginally applied integrase inhibitors in macaques
Authors: Nishiura Kenji , Sharma Sunita , Sterling Mara , Makarova Natalia , Martin Amy , Dinh Chuong , Mitchell James , García-Lerma J Gerardo , Heneine Walid , Dobard Charles 
Published: August 2021

Abstract

Objectives
We conducted a detailed pharmacokinetic assessment in macaques treated with vaginal gels formulated with HIV integrase strand transfer inhibitors (INSTIs) to better understand drug distribution and identify INSTI concentrations associated with previously demonstrated in vivo protection against vaginal simian HIV challenge.

Methods
Six macaques received vaginal gel containing 1% raltegravir (30 mg) once-weekly over 6 weeks. Following a washout period, five macaques received once-weekly gel containing 0.23% L-870,812 (7 mg). Drug concentrations were measured in plasma, mucosal fluids and vaginal tissues at baseline and 2, 5 and 24 h post-dosing.

Results
The median maximum concentration (Cmax) for raltegravir and L-870,812 in plasma was below the limit of quantification and 41.1 ng/mL, respectively. The Cmax in vaginal fluids (1441 and 1250 μg/mL) and tissues (266.7 and 368.4 μg/g) was achieved 2–5 h after dosing, respectively. A similar half-life was observed for raltegravir and L-870,812 in vaginal fluids (8–10 h) and remained 3–4 orders of magnitude above the protein-adjusted IC95 (0.016 and 0.106 μg/mL, respectively) at 24 h. Drug concentrations in vaginal fluids correlated well with those in vaginal tissues (Pearson r ≥ 0.788). Both drugs were consistently detected in rectal fluids 2 h after vaginal dosing, albeit at much lower levels (31–92-fold) than those in vaginal fluids.

Conclusions
To the best of our knowledge, this study provides the first data on INSTI levels in vaginal tissues associated with in vivo protection and demonstrates rectal drug distribution of INSTIs after vaginal dosing. These findings may inform dose selection for topical products with INSTIs for HIV prevention.
Prediction of ceftriaxone MIC inNeisseria gonorrhoeae usingDNA microarray technology and regression analysis
Authors: Shaskolskiy Boris , Kandinov Ilya , Kravtsov Dmitry , Filippova Marina , Chestkov Alexander , Solomka Victoria , Kubanov Alexey , Deryabin Dmitry , Dementieva Ekaterina , Gryadunov Dmitry 
Published: August 2021

AbstractBackgroundDecreased susceptibility of Neisseria gonorrhoeae to extended-spectrum cephalosporins is a major concern. Elucidation of the phenotypic and genetic characteristics of such isolates is a priority task.MethodsWe developed a method for predicting the N. gonorrhoeae ceftriaxone susceptibility level (MICcro) by identifying genetic determinants of resistance using low-density hydrogel microarrays and a regression equation. A training dataset, containing 5631 isolates from the Pathogenwatch database and 181 isolates obtained in the Russian Federation during 2018–19, was used to build a regression model. The regression equation was tested on 14 WHO reference strains. Ceftriaxone resistance determinants for the 448 evaluated clinical isolates collected in Russia were identified using microarray analysis, and MICcro values were calculated using the regression equation and compared with those measured by the serial dilution method.ResultsThe regression equation for calculating MICcro values included 20 chromosomal resistance determinants. The greatest contributions to the increase in MICcro were shown to be PBP2: Ala-501→Pro, Ala-311→Val, Gly-545→Ser substitutions, Asp(345–346) insertion; and PorB: Gly-120→Arg substitution. The substitutions PBP2: Ala-501→Thr/Val, PorB: Gly-120→Asn/Asp/Lys and PBP1: Leu-421→Pro had weaker effects. For 94.4% of the isolates in the evaluation set, the predicted MICcro was within one doubling dilution of the experimentally determined MICcro. No ceftriaxone-resistant isolates were identified in the analysed samples from Russia, and no interpretative errors were detected in the MICcro calculations.ConclusionsThe developed strategy for predicting ceftriaxone MIC can be used for the continuous surveillance of known and emerging resistant N. gonorrhoeae isolates.
Crohn’s and Colitis Canada’s 2021 Impact of COVID-19 and Inflammatory Bowel Disease in Canada: Risk Factors and Medications
Authors: Targownik Laura E , Bernstein Charles N , Lakatos Peter L , Murthy Sanjay K , Benchimol Eric I , Bitton Alain , Huang James Guoxian , Kuenzig M Ellen , Jones Jennifer L , Kaplan Gilaad G , Lee Kate , Mukhtar Mariam S , Tandon Parul , Windsor Joseph W , Panaccione Remo 
Published: August 2021

Abstract
Inflammatory bowel disease (IBD) is a disease that results from dysregulation of the immune system and frequently requires medications that can affect the immune response to infections; therefore, it was imperative to quickly understand the risk of coronavirus disease 2019 (COVID-19) infection on persons living with IBD and how that risk may be increased by commonly used IBD medications. The IBD research community in Canada and beyond quickly established collaborative efforts to better understand the specific risk posed by COVID-19 on persons with IBD. We learned that IBD itself was not a risk factor for death or serious complications of COVID-19, and that most commonly used drug classes (with the notable exception of corticosteroids) do not increase the risk of COVID-19-related adverse outcomes. The risk factors for serious complications and death from COVID-19 appear to be similar to those identified in the wider population; those being advanced age, having pre-existing heart or lung disease, and smoking. We recommend that persons with IBD do not alter their course of therapy to avoid complications of COVID-19, though the indiscriminate use of corticosteroids should be avoided. Persons with IBD should follow the same public health recommendations as the general population to reduce their personal risk of acquiring COVID-19.
A Duty to Care: The Case of Sharma v Minister for the Environment [2021] FCA 560
Authors: Peel Jacqueline , Markey-Towler Rebekkah 
Published: August 2021

Abstract
This analysis considers the implications of Sharma v Minister for the Environment [2021] FCA 560 and its finding of a novel duty of care owed by the Australian Government to children to prevent climate harms. While the judgment of a single Federal Court justice is likely to be appealed and did not result in an injunction halting the coal mine, its close consideration of scientific evidence of climate impacts and recognition of the special vulnerability of children has potentially profound ramifications for the ongoing development of climate litigation, both in Australia and globally. More broadly, the Sharma decision adds to growing momentum for governments to be held accountable for their actions on climate change, effectively calling for a duty to care in the face of inter-generational injustices inflicted by inaction on reducing greenhouse gas emissions to safe levels.
Disposition of magmatic eruptions and fault distribution in northwestern Saudi Arabia using pseudo-depth slice magnetic anomaly
Authors: Ibrahim Elkhedr , Arfaoui Mohamed , Mogren Saad , Qaysi Saleh , Lashin Aref , Alfaifi Hussain 
Published: August 2021

AbstractThis study presents the disposition of magmatic eruptions with a fault distribution in northwestern Saudi Arabia, where intensive magma invades the lithosphere. Structural and magmatic features are traced at successive depths through high-resolution magnetic anomaly pseudo-depth slices. The total horizontal gradient technique is applied to pseudo-depth slice magnetic anomalies to enhance the linear trends of faults and related magmatic activity. A comprehensive cross-section constructed from the projection of gradient horizontal maxima relative to pseudo-slices allows the visualization of the vertical behavior of faults and magma sources. Three major fault systems were identified, primarily aligned in the N–S, NE–SW and NW–SE directions. They are characterized by increasing length and width with depth. The N-S fault system is a major non-planar deep system throughout the area, affected by the NW–SE and NE–SW deep discontinuities. The evolution of these discontinuities with depth successfully shows magma uprising zones represented by a circular horizontal gradient, which starts to appear at a depth of 4500 m with a vertical continuity to the surface. They are interpreted as possible locations of ascending magma chambers or vents. The disposition of these magma sources with fault distribution can show a close relationship between the fault systems and the magma eruptions. The interpreted magma vents appear where the NE-trending transform faults intersect the NW or N–S fault zone. These intersections may represent weak zones that act as vertical conduits through which magma discontinuously erupts into the overlying crust, forming major volcanic fields in the eastern Red Sea.
Spatially resolved star formation and inside-out quenching in the TNG50 simulation and 3D-HST observations
Authors: Nelson Erica J , Tacchella Sandro , Diemer Benedikt , Leja Joel , Hernquist Lars , Whitaker Katherine E , Weinberger Rainer , Pillepich Annalisa , Nelson Dylan , Terrazas Bryan A , Nevin Rebecca , Brammer Gabriel B , Burkhart Blakesley , Cochrane Rachel K , van Dokkum Pieter , Johnson Benjamin D , Marinacci Federico , Mowla Lamiya , Pakmor Rüdiger , Skelton Rosalind E , Speagle Joshua , Springel Volker , Torrey Paul , Vogelsberger Mark , Wuyts Stijn 
Published: August 2021

ABSTRACT
We compare the star-forming main sequence (SFMS) of galaxies – both integrated and resolved on 1 kpc scales – between the high-resolution TNG50 simulation of IllustrisTNG and observations from the 3D-HST slitless spectroscopic survey at z ∼ 1. Contrasting integrated star formation rates (SFRs), we find that the slope and normalization of the star-forming main sequence in TNG50 are quantitatively consistent with values derived by fitting observations from 3D-HST with the Prospector Bayesian inference framework. The previous offsets of 0.2–1 dex between observed and simulated main-sequence normalizations are resolved when using the updated masses and SFRs from Prospector. The scatter is generically smaller in TNG50 than in 3D-HST for more massive galaxies with M*&gt; 1010 M⊙, by ∼10–40 per cent, after accounting for observational uncertainties. When comparing resolved star formation, we also find good agreement between TNG50 and 3D-HST: average specific star formation rate (sSFR) radial profiles of galaxies at all masses and radii below, on, and above the SFMS are similar in both normalization and shape. Most noteworthy, massive galaxies with M*&gt; 1010.5 M⊙, which have fallen below the SFMS due to ongoing quenching, exhibit a clear central SFR suppression, in both TNG50 and 3D-HST. In contrast, the original Illustris simulation and a variant TNG run without black hole kinetic wind feedback, do not reproduce the central SFR profile suppression seen in data. In TNG, inside-out quenching is due to the supermassive black hole (SMBH) feedback model operating at low accretion rates.
Towards constraining warm dark matter with stellar streams through neural simulation-based inference
Authors: Hermans Joeri , Banik Nilanjan , Weniger Christoph , Bertone Gianfranco , Louppe Gilles 
Published: August 2021

ABSTRACT
A statistical analysis of the observed perturbations in the density of stellar streams can in principle set stringent constraints on the mass function of dark matter subhaloes, which in turn can be used to constrain the mass of the dark matter particle. However, the likelihood of a stellar density with respect to the stream and subhaloes parameters involves solving an intractable inverse problem which rests on the integration of all possible forward realizations implicitly defined by the simulation model. In order to infer the subhalo abundance, previous analyses have relied on Approximate Bayesian Computation (ABC) together with domain-motivated but handcrafted summary statistics. Here, we introduce a likelihood-free Bayesian inference pipeline based on Amortised Approximate Likelihood Ratios (AALR), which automatically learns a mapping between the data and the simulator parameters and obviates the need to handcraft a possibly insufficient summary statistic. We apply the method to the simplified case where stellar streams are only perturbed by dark matter subhaloes, thus neglecting baryonic substructures, and describe several diagnostics that demonstrate the effectiveness of the new method and the statistical quality of the learned estimator.
Morphostatistical characterization of the spatial galaxy distribution through Gibbs point processes
Authors: Hurtado-Gil Lluís , Stoica Radu S , Martínez Vicent J , Arnalte-Mur Pablo 
Published: August 2021

ABSTRACTThis paper proposes a morphostatistical characterization of the galaxy distribution through spatial statistical modelling based on inhomogeneous Gibbs point processes. The galaxy distribution is supposed to exhibit two components. The first one is related to the major geometrical features exhibited by the observed galaxy field, here, its corresponding filamentary pattern. The second one is related to the interactions exhibited by the galaxies. Gibbs point processes are statistical models able to integrate these two aspects in a probability density, controlled by some parameters. Several such models are fitted to real observational data via the ABC shadow algorithm. This algorithm provides simultaneous parameter estimation and posterior-based inference, hence allowing the derivation of the statistical significance of the obtained results.
Comparing hypervelocity star populations from the Large Magellanic Cloud and the Milky Way
Authors: Evans F A , Marchetti T , Rossi E M , Baggen J F W , Bloot S 
Published: August 2021

ABSTRACT
We predict and compare the distributions and properties of hypervelocity stars (HVSs) ejected from the centres of the Milky Way (MW) and the Large Magellanic Cloud (LMC). In our model, HVSs are ejected at a constant rate – equal in both galaxies – via the Hills mechanism and are propagated in a combined potential, where the LMC orbits the MW on its first infall. By selecting $m \gt 2\, \mathrm{M_\odot }$ HVSs well separated from the Magellanic Clouds and Galactic mid-plane, we identify mock HVSs which would stand out from ordinary stars in the stellar halo in future data releases from the Gaia satellite and the Vera C. Rubin Observatory’s Legacy Survey of Space and Time (LSST). We find that in these deep surveys, LMC HVSs will outnumber MW ones by a factor of ∼2.5, as HVSs can more easily escape from the shallower potential of the LMC. At an assumed HVS ejection rate of $10^{-4} \, \mathrm{yr^{-1}}$, HVSs detectable in the final Gaia data release and LSST from the LMC (MW) will number $125_{-12}^{+11}$ ($50_{-8}^{+7}$) and $140_{-11}^{+10}$ ($42_{-7}^{+6}$), respectively. The MW and LMC HVS populations show different kinematics and spatial distributions. While LMC HVSs have more modest total velocities and larger Galactocentric distances clustered around those of the LMC itself, HVSs from the MW show broader distributions, including a prominent high-velocity tail above $500 \, \mathrm{km \ s^{-1}}$ that contains at least half of the stars. These predictions are robust against reasonable variation of the Galactic potential and of the LMC central black hole mass.
J2102+6015: a young radio source at z = 4.575
Authors: Zhang Yingkang , An Tao , Frey Sándor , Yang Xiaolong , Krezinger Máté , Titov Oleg , Melnikov Alexey , de Vicente Pablo , Shu Fengchun , Wang Ailing 
Published: August 2021

ABSTRACT
Jets of high-redshift active galactic nuclei (AGNs) can be used to directly probe the activity of the black holes in the early Universe. Radio sources with jets misaligned with respect to the line of sight are expected to dominate the high-redshift AGN population. In this paper, we present the high-resolution imaging results of a z = 4.57 AGN J2102+6015 by analysing its multi-epoch dual-frequency very long baseline interferometry (VLBI) data. The 8.4-GHz VLBI images reveal two major features along the east–west direction separated by ∼10 mas. From the spectral index map, both features show flat/inverted spectra. The separation between the two features remains almost unchanged over an observation period of ∼13 yr, placing an upper limit of the separation speed as about 0.04 mas yr−1. Previous studies have classified the source as a GHz-peaked spectrum quasar. Our results indicate that J2102+6015 is most likely a young, compact symmetric object rather than a blazar-type core–jet source.
Common envelope evolution of eccentric binaries
Authors: Glanz Hila , Perets Hagai B 
Published: August 2021

ABSTRACT
Common envelope evolution (CEE) is believed to be an important stage in the evolution of binary/multiple stellar systems. Following this stage, the CE is thought to be ejected, leaving behind a compact binary (or a merger product). Although extensively studied, the CEE process is still little understood, and although most binaries have non-negligible eccentricity, the effect of initial eccentricity on the CEE has been little explored. Moreover, most studies assume a complete circularization of the orbit by the CE onset, while observationally such eccentricities are detected in many post-CE binaries. Here we use smoothed particle hydro-dynamical simulations to study the evolution of initially eccentric (0 ≤ e ≤ 0.95) CE-systems. We find that initially eccentric binaries only partially circularize. In addition, higher initial eccentricity leads to a higher eccentricity following the end of the inspiral phase, with eccentricities as high as 0.18 in the most eccentric cases, and even higher if the initial pericentre of the orbit is located inside the star (e.g. following a kick into an eccentric orbit, rather than a smooth transition). CEE of more eccentric binaries leads to enhanced dynamical mass-loss of the CE compared with more circular binaries, and depends on the initial closest approach of the binary. We show that our results and the observed eccentricities of post-CE binaries suggest that the typical assumptions of circular orbits following CEE might potentially be revised. We expect post-CE eccentricities to affect the delay time distributions of various transients such as supernovae, gamma-ray bursts, and gravitational-wave sources by up to tens of per cents.