bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine Learning Based Novelty Detection Methods for Progressive Stamping Process Health Monitoring
Authors: Qiu Tianchen , Lai Xingjian , Ni Jun 
Published: January 2021

Abstract
Progressive (die) stamping is a widely used sheet metal forming process in the manufacturing of automobiles and consumer electronics. Current literature suggests limited knowledge of online health monitoring and fault detection capability. This paper aims to propose a data-driven, empirical approach for diagnosing potential abnormal health conditions of the progressive stamping machine. The proposed signal features and selected novelty detection algorithm work together for fault diagnosis and compensate for the lack of theoretical knowledge of this high-volume high-speed production process. Novelty detection, usually approached within the framework of one-class classification, demonstrates luminous potential applications in machine system health monitoring. During progressive stamping process, there are abundant normal operating data while it is unclear how complex machine health factors together affect the feature signals. The task is to recognize the abnormality by recognizing the significance of how testing data differ from training data by forming a decision boundary from normal behaving training data only. Through literature review, One-Class Support Vector Machine (OCSVM) is selected as the main algorithm for this application. Through applying kernel tricks, the hyperplane can be used to classify nonlinear machine health indictors. OCSVM also utilizes sparse supporting vectors to form a computationally efficient decision boundary and can therefore be used for online fault detections. In this study, the proposed novelty detection approach is explained and successfully implemented based on industrial data from a progressive stamping machine. The paper discusses the promising results and potential limitations.
Mathematical Modeling of Thermal Behavior in Layer-by-Layer Part Fabrication by Direct Metal Laser Sintering Process for Different Scanning Patterns
Authors: Sezer Hayri , Ahsan Nazmul , Kozhumal Shijin P. , Ritenour Andy , Kaul Sudhir 
Published: January 2021

Abstract
In direct metal laser sintering process (DMLS), the nonuniform heat transfer and resulting temperature gradient across the part result in thermal residual stress within the part which introduces local deformation. This overall effect ultimately leads to part distortion and affects the mechanical properties of the part. As far as temperature gradient and thermal residual stress are concerned, the crucial process parameter that can be tailored to alleviate the thermal anisotropic effect from the laser heat source is the scanning pattern. In this study, an in-house transient three-dimensional computational model has been developed to analyze thermal behavior in the DMLS process for different scanning patterns. The governing equations for heat transfer are discretized using a finite volume method. An implicit scheme is used for time integration. The thermo-physical properties, thermal conductivity of the metal powder, convection heat transfer coefficient, and specific heat of the metal powder are updated for every time step. The model considers convective and radiative Neumann boundary conditions for the lateral and top surfaces and a constant temperature boundary condition for the bottom surface of rectangular geometries. The laser power is implemented as a moving radiative Neumann boundary condition that follows any given scanning pattern. In this study, two contour parallel (spiral) scanning patterns, center to edge and edge to center, and their corresponding thermal effects have been analyzed. The results show that rectangular spiral pattern with a center to edge scanning direction has the lowest thermal gradient which results in the lowest residual stresses.
Investigation of the Influence of Consequential Design Parameters on the Mechanical Performance of Biodegradable Bone Scaffolds, Fabricated Using Pneumatic Micro-Extrusion Additive Manufacturing Process
Authors: Zhao Daguan , Yu Mohan , Lawrence Logan , Claudio Pier Paolo , Day James B. , Salary Roozbeh (Ross) 
Published: January 2021

Abstract
Pneumatic micro-extrusion (PME) is a high-resolution direct-write additive manufacturing process, which has emerged as the process of choice for tissue engineering and biofabrication of a broad spectrum of organs and tissues (e.g., bone, aortic valve, blood vessels, human ear, and nose). Despite the advantages and host of biomedical applications engendered by the PME process — including, for example, (i) accommodation of a wide range of material viscosity (enabled via thermopneumatic material deposition), (ii) large build volume and standoff distance for tissue engineering, (iii) in situ UV curing, and (iv) high-resolution multimaterial deposition — there are intrinsically complex design, material, and process factors as well as interactions, which influence the functional properties of PME-fabricated tissues and organs. Consequently, investigation of the impact and interaction of each factor aligned with establishment of a physics-based, optimal material deposition regime is inevitably a burgeoning need.
In this study, using the Taguchi design, the influence of four significant factors, i.e., layer height, infill density, infill pattern, and print speed, is investigated on the compression properties as well as the dimensional accuracy of polycaprolactone (PCL) bone scaffolds, fabricated using the PME process. Furthermore, a 3D, transient two-phase flow CFD model is forwarded with the aim to observe the flow of material within the deposition head as well as the micro-capillary (nozzle). The results of this study pave the way for further investigation of the bio-functional properties of bone scaffolds, e.g., biodegradation, cell proliferation and growth rate.
Inhomogeneous and Anisotropic Mechanical Properties of the Triceps Surae Aponeuroses in Older Adults: Relationships With Muscle Strength and Walking Performance
Authors: Shan Xiyao , Evangelidis Pavlos , Yamagishi Takaki , Otsuka Shun , Tanaka Fumiko , Shibata Shigenobu , Kawakami Yasuo 
Published: January 2021

This study investigated (a) site- and direction-dependent variations of passive triceps surae aponeurosis stiffness and (b) the relationships between aponeurosis stiffness and muscle strength and walking performance in older individuals. Seventy-nine healthy older adults participated in this study. Shear wave velocities of the triceps surae aponeuroses at different sites and in two orthogonal directions were obtained in a prone position at rest using supersonic shear imaging. The maximal voluntary isometric contraction torque of the plantar flexors and normal (preferred) and fast (fastest possible) walking speeds (5-m distance) were also measured. The shear wave velocities of the adjoining aponeuroses were weakly associated with plantar flexion torque (r = .23–.34), normal (r = .26), and fast walking speed (r = .25). The results show clear spatial variations and anisotropy of the triceps surae aponeuroses stiffness in vivo, and the aponeurosis stiffness was associated with physical ability in older adults.
Towards individualised contraceptive counselling: clinical and reproductive factors associated with self-reported hormonal contraceptive-induced adverse mood symptoms
Authors: Lundin Cecilia , Wikman Anna , Bixo Marie , Gemzell-Danielsson Kristina , Sundström Poromaa Inger 
Published: January 2021

ObjectiveThe study aim was to establish which demographic, clinical, reproductive and psychiatric factors are associated with self-reported hormonal contraceptive (HC)-induced adverse mood symptoms.Study designWe compiled baseline data from two Swedish studies: one cross-sectional study on combined oral contraceptive (COC)-induced adverse mood symptoms (n=118) and one randomised controlled trial on adverse mood symptoms on COC (n=184). Both included women eligible for COC use, aged over 18 years. All women answered a questionnaire on HC use and associated mood problems. The Mini-International Neuropsychiatric Interview (M.I.N.I.) was used to capture mood and anxiety disorders. Women who acknowledged HC-induced adverse mood symptoms, ongoing or previously (n=145), were compared with women without any such experience (n=157).ResultsCompared with women without self-reported HC-induced adverse mood symptoms, women with these symptoms were younger at HC start (adjusted odds ratio (aOR) 0.83, 95% CI 0.72 to 0.95), had more often undergone induced abortion (OR 3.36, 95% CI 1.57 to 7.23), more often suffered from an ongoing minor depressive disorder (n=12 vs n=0) and had more often experienced any previous mental health problem (aOR 1.90, 95% CI 1.01 to 3.59).ConclusionsIn line with previous research, this study suggests that women with previous or ongoing mental health problems and women who are younger at HC start are more likely to experience HC-induced adverse mood symptoms. Former and current mental health should be addressed at contraceptive counselling, and ongoing mental health disorders should be adequately treated.ImplicationsThis study adds valuable knowledge for identification of women susceptible to HC-induced adverse mood symptoms. It should facilitate the assessment of whether or not a woman has an increased risk of such symptoms, and thus enable clinicians to adopt a more personalised approach to contraceptive counselling.
Loss of Wip1 aggravates brain injury after ischaemia/reperfusion by overactivating microglia
Authors: Yan Feng , Cheng Xiang , Zhao Ming , Gong Shenghui , Han Ying , Ding Liping , Wu Di , Luo Yumin , Zuo Wei , Zhu Lingling , Fan Ming , Ji Xunming 
Published: January 2021

Background and purposeThe inflammatory response mediated by microglia/macrophages is closely related to cerebral ischaemia/reperfusion injury. Wild-type p53-induced protein phosphatase 1 (Wip1), a serine/threonine phosphatase, is expressed in various tissues. A growing number of reports have suggested that Wip1 is a negative regulator of inflammation in peripheral tissue; however, its role in the central nervous system (CNS) remains unclear. This study aimed to clarify whether Wip1 can inhibit CNS inflammation by regulating microglia/macrophage functions after ischaemic injury.MethodsA model of middle cerebral artery occlusion and reperfusion was established in mice. CNS inflammation was simulated by lipopolysaccharide treatment of primary microglia. Laser speckle imaging was used to monitor regional cerebral blood flow. Behavioural outcomes were assessed with a TreadScan gait analysis system. TTC staining was used to evaluate the infarct volume, and western blotting and immunofluorescence staining were applied to detect the phenotypical transformation of microglia. ELISA was performed to detect the levels of inflammatory factors.ResultsWip1 expression was increased after ischaemia/reperfusion. Wip1-knockout (KO) mice displayed more severe brain injury than wild-type mice, as indicated by aggravated motor dysfunction, greater brain infarct volumes and higher expression of inflammatory cytokines (interleukin-6 and tumour necrosis factor alpha) in the brain. We also found that Wip1 depletion increased microglial/macrophage activation in both in vitro and in vivo models, which all showed activation of microglia/macrophages. Lentivirus-Ppm1dreversed the injury induced by Wip1-KO.ConclusionsOur results suggest that Wip1 may inhibit neuroinflammation by inhibiting microglial/macrophage activation after brain ischaemia/reperfusion injury.
Phase I Study of the CD47 Blocker TTI-621 in Patients with Relapsed or Refractory Hematologic Malignancies
Authors: Ansell Stephen M. , Maris Michael B. , Lesokhin Alexander M. , Chen Robert W. , Flinn Ian W. , Sawas Ahmed , Minden Mark D. , Villa Diego , Percival Mary-Elizabeth M. , Advani Anjali S. , Foran James M. , Horwitz Steven M. , Mei Matthew G. , Zain Jasmine , Savage Kerry J. , Querfeld Christiane , Akilov Oleg E. , Johnson Lisa D.S. , Catalano Tina , Petrova Penka S. , Uger Robert A. , Sievers Eric L. , Milea Anca , Roberge Kathleen , Shou Yaping , O'Connor Owen A. 
Published: January 2021

Abstract

Purpose:
TTI-621 (SIRPα-IgG1 Fc) is a novel checkpoint inhibitor that activates antitumor activity by blocking the CD47 “don't eat me” signal. This first-in-human phase I study (NCT02663518) evaluated the safety and activity of TTI-621 in relapsed/refractory (R/R) hematologic malignancies.

Patients and Methods:
Patients with R/R lymphoma received escalating weekly intravenous TTI-621 to determine the maximum tolerated dose (MTD). During expansion, patients with various malignancies received weekly single-agent TTI-621 at the MTD; TTI-621 was combined with rituximab in patients with B-cell non-Hodgkin lymphoma (B-NHL) or with nivolumab in patients with Hodgkin lymphoma. The primary endpoint was the incidence/severity of adverse events (AEs). Secondary endpoint included overall response rate (ORR).

Results:
Overall, 164 patients received TTI-621: 18 in escalation and 146 in expansion (rituximab combination, n = 35 and nivolumab combination, n = 4). On the basis of transient grade 4 thrombocytopenia, the MTD was determined as 0.2 mg/kg; 0.1 mg/kg was evaluated in combination cohorts. AEs included infusion-related reactions, thrombocytopenia, chills, and fatigue. Thrombocytopenia (20%, grade ≥3) was reversible between doses and not associated with bleeding. Transient thrombocytopenia that determined the initial MTD may not have been dose limiting. The ORR for all patients was 13%. The ORR was 29% (2/7) for diffuse large B-cell lymphoma (DLBCL) and 25% (8/32) for T-cell NHL (T-NHL) with TTI-621 monotherapy and was 21% (5/24) for DLBCL with TTI-621 plus rituximab. Further dose optimization is ongoing.

Conclusions:
TTI-621 was well-tolerated and demonstrated activity as monotherapy in patients with R/R B-NHL and T-NHL and combined with rituximab in patients with R/R B-NHL.
Time-Restricted Salutary Effects of Blood Flow Restoration on Venous Thrombosis and Vein Wall Injury in Mouse and Human Subjects
Authors: Li Wenzhu , Kessinger Chase W. , Orii Makoto , Lee Hang , Wang Lang , Weinberg Ido , Jaff Michael R. , Reed Guy L. , Libby Peter , Tawakol Ahmed , Henke Peter K. , Jaffer Farouc A. 
Published: January 2021

Background:
Up to 50% of patients with proximal deep vein thrombosis (DVT) will develop the postthrombotic syndrome characterized by limb swelling and discomfort, hyperpigmentation, skin ulcers, and impaired quality of life. Although catheter-based interventions enabling the restoration of blood flow (RBF) have demonstrated little benefit on postthrombotic syndrome, the impact on the acuity of the thrombus and mechanisms underlying this finding remain obscure. In experimental and clinical studies, we examined whether RBF has a restricted time window for improving DVT resolution.

Methods:
First, experimental stasis DVT was generated in C57/BL6 mice (n=291) by inferior vena cava ligation. To promote RBF, mice underwent mechanical deligation with or without intravenous recombinant tissue plasminogen activator administered 2 days after deligation. RBF was assessed over time by ultrasonography and intravital microscopy. Resected thrombosed inferior vena cava specimens underwent thrombus and vein wall histological and gene expression assays. Next, in a clinical study, we conducted a post hoc analysis of the ATTRACT (Acute Venous Thrombosis: Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis) pharmacomechanical catheter-directed thrombolysis (PCDT) trial (NCT00790335) to assess the effects of PCDT on Venous Insufficiency Epidemiological and Economic Study quality-of-life and Villalta scores for specific symptom-onset-to-randomization timeframes.

Results:

Mice that developed RBF by day 4, but not later, exhibited reduced day 8 thrombus burden parameters and reduced day 8 vein wall fibrosis and inflammation, compared with controls. In mice without RBF, recombinant tissue plasminogen activator administered at day 4, but not later, reduced day 8 thrombus burden and vein wall fibrosis. It is notable that, in mice already exhibiting RBF by day 4, recombinant tissue plasminogen activator administration did not further reduce thrombus burden or vein wall fibrosis. In the ATTRACT trial, patients receiving PCDT in an intermediate symptom-onset-to-randomization timeframe of 4 to 8 days demonstrated maximal benefits in Venous Insufficiency Epidemiological and Economic Study quality-of-life and Villalta scores (between-group difference=8.41 and 1.68, respectively,
P
<0.001 versus patients not receiving PCDT). PCDT did not improve postthrombotic syndrome scores for patients having a symptom-onset-to-randomization time of <4 days or >8 days.

Conclusions:
Taken together, these data illustrate that, within a restricted therapeutic window, RBF improves DVT resolution, and PCDT may improve clinical outcomes. Further studies are warranted to examine the value of time-restricted RBF strategies to reduce postthrombotic syndrome in patients with DVT.
Gonadal cycle of the blue crab Portunus segnis (Forskål, 1775) (Decapoda, Portunoidea) in the Mediterranean Sea off Alexandria, Egypt
Authors: Gaber Ibrahim , Luisetto Mauro , Latyshev Oleg 
Published: January 2021

Abstract
Adults of Portunus segnis were captured from Ras el Tin beach on the Mediterranean Sea at Alexandria, Egypt, from January to December 2017. Male crabs are present in higher density in the sea during fall and winter, while female crabs are more common during spring and summer. Sex ratios were calculated as follows: number of males or females/total number of crabs. The calculated sex ratios were subjected to a Chi-square test according to the equation: , where O represents the observed frequency and E the expected frequency. One-way analysis of variance shows differences in the carapace size (length and width) and the weight of males and females during the four seasons. The hepatosomatic index of male crabs ranges from 9.1-9.25 in winter months, 8.7-7.9 in fall, being lower, 3.12-2.25, in spring and 5.96-4.13 in summer. The hepatosomatic index of female crabs is 8.9-3.9 in spring, 9.2-7.9 in summer, shifts lower to 5.1-3.2 in fall and to 4.2-1.5 in winter. The gonadosomatic index of female crabs is 0.12-8.2 in spring, 0.20-13.9 in summer and decreases to 0.66-7.8 in fall and 0.18-4.7 in winter. Ovaries and testes were isolated, fixed, and prepared for histological examination. The testicular lobes are surrounded by simple epithelium with haemolymph filling the interspaces. Seminiferous ducts are inserted in the testicular lobes. Spermatogenesis and spermiogenesis are described. The vas deferens is usually filled with spermatophores. Spermatophore formation begins in the testis near the vas deferens. Near the base of the penes there is glandular tissue. This study proposes the classification of the ovarian maturation into five stages: Stage I, Immature ovary with primary and secondary oogonia; Stage II, early maturing ovary with germ cells in different maturation phases; Stage III, mature ovary with vitellogenic oocytes and germ cells; Stage IV, maturing ovary with oocytes I, II and fully mature oocytes; and Stage V, ovary in regeneration. The wall of the spermatheca consists of a stratified squamous epithelium.
First record of the symbiotic palaemonid shrimp Hamodactylus boschmai Holthuis, 1952 (Decapoda, Caridea) from Korea
Authors: Park Jin-Ho , Lee Damin , Park Taeseo 
Published: January 2021

Abstract
Here, the symbiotic palaemonid shrimp Hamodactylus boschmai is recorded from Korean waters for the first time, based on specimens collected from different invertebrate hosts by trimix diving at depths of between 45 and 60 m in Jejudo Island. This species can readily be distinguished from its congeners by the presence of a distinct supraorbital tooth, the proximal segment of the antennular peduncle having a single tooth on the distolateral margin, the presence of a denticulate lamina along the entire cutting edge of the fingers of the first pereiopod chela, and the chela of the second pereiopods having a strongly hooked tip on the movable finger. An illustrated description, colour photographs, and a comparison of partial mitochondrial cytochrome c oxidase subunit I gene sequences are provided.
The Scent of the Righteous vs. the Scent of the Wicked: Body Odor as a Social Indicator of Morality in Rabbinic Literature
Authors: Shemesh Abraham Ofir 
Published: January 2021

Abstract
Perceiving the odor emitted by one’s body or clothes as a manifestation of moral identity is a cross-cultural sociological and literary phenomenon. Odors were perceived as a mark that set social boundaries and they made it possible to distinguish between groups of people by their status or identity. In the Christian, Muslim, and Bahai traditions holy people, such as prophets, martyrs, and shahids, were perceived or described as smelling good. In Jewish cultural discourse, smell is a sociological-religious indicator that distinguishes, whether symbolically or realistically, between the good and the corrupt. The term “foul smell” is mentioned in association with negative people, mainly with regard to sexual promiscuity. In contrast, a good fragrance is emblematic of the Patriarchs (Abraham), people with stringent sexual morals (Joseph), and Torah scholars.
Sforno’s Threefold Approach to the Torah’s Structure
Authors: Sklarz Miriam 
Published: January 2021

Abstract
Classical exegetes’ exploration of structure and order in the Pentateuch is generally perceived as part of an internal-Jewish debate. However, in an exceptional testimonial, the introduction to R. Ovadiah Sforno’s Torah commentary describes a polemic against the Torah grounded in a claim about the Torah’s disorderliness. Responding to this critique, Sforno set out to uncover the Torah’s logical order. His efforts to elucidate the Torah’s order and structure include three aspects: he points to a circular structure that is repeated seven times in Genesis-Numbers, he systematically links the independent legal sections in Deuteronomy, and he discusses the Torah’s division into five separate books. While methodically addressing the question of order, Sforno also offers a response to fundamental theological issues at the center of the interfaith polemic.
The Semiotics of the Medical Face Mask: East and West
Authors: Leone Massimo 
Published: January 2021

Abstract
After a concise survey of the state of the art on the semiotics of the mask and on studies in humanities and social sciences about medical face masks, the essay provides anecdotic evidence about differences in the semiotics of medical face masks in Europe and in the ‘Far East’, especially Japan, China, and Korea; it proposes a semiotic grid for decoding the phenomenology and meaning of the medical face mask; it concludes with some general observations on the change of the meaning of the face during the current pandemic.
The ‘Neutral’ – the Semiotic Paradigm of Sinogram
Authors: Meng Hua , Gong Xuemei 
Published: January 2021

Abstract
Redefining Roland Barthes’ term ‘The neutral’ as ‘the neutrality and dissolution of the dualistic opposition’, this paper argues that Chinese characters are quasi-characters, quasi-signs, and neuter. The unique paradigm of Chinese characters is revealed by comparing the neuter phenomena of ‘centrifugalisation’ and ‘centripetalisation’ between pictures and characters, thus highlighting the significance of such a paradigm to contemporary semiotic studies.