bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐Patterned CsPbBr3 Nanocrystal Based Plasmonic Hot‐Carrier Photodetector at Telecommunications Wavelengths
Authors: Wang Zhiyu , Lin Cheng‐Chieh , Ho Ya‐Lun , Xiang Rong , Maruyama Shigeo , Chen Chun‐Wei , Delaunay Jean‐Jacques 
Published: September 2021

AbstractExtending the photodetection range of lead halide perovskites into the near‐infrared telecommunications bands can not only enable a wide‐spectrum solar energy harvesting, but pave ways for important applications in biodetection, infrared imaging, and telecommunication. However, there is a lack of an effective means to apply lead halide perovskites for efficient photodetection covering a wide wavelength range in the telecommunications bands. Here, CsPbBr3 nanocrystal‐ (NC‐) based photodetector operating at wavelengths in the telecommunications bands via surface plasmon‐induced hot holes is demonstrated. The internal photoemission of the plasmon‐induced hot holes from plasmonic antennas into CsPbBr3 NCs enables a photocurrent at wavelengths around 1550 nm. Moreover, a solvent treatment is also performed on drop‐casted CsPbBr3 NC thin film leading to a nanoscale self‐patterning with a compact and uniform morphology. This treatment benefits the carrier transportation contributing to a detectable photoresponse and minimizes the optical scattering so that the CsPbBr3 NCs can be integrated into the plasmonic structure without damping its resonant feature. Consequently, the CsPbBr3 NC‐based plasmonic hot‐carrier device achieves polarization discrimination and wavelength‐selective photodetection without additional optical components.
Data management schema design for effective nanoparticle formulation for neurotherapeutics
Authors: Helmbrecht Hawley , Xu Nuo , Liao Rick , Nance Elizabeth 
Published: September 2021

AbstractTranslation of nanotherapeutics from preclinical research to clinical application is difficult due to the complex and dynamic interaction space between the nanotherapeutic and the brain environment. To improve translation, increased insight into nanoformulation‐brain interactions in preclinical research is necessary. We developed a nanoformulation‐brain database and wrote queries to connect the complex physical, chemical, and biological features of neurotherapeutics based on experimental data. We queried the database to select nanoformulations based on specific physical characteristics that enable effective penetration within the brain, including size, polydispersity index, and zeta potential. Additionally, we demonstrate the ability to query the database to return select nanoformulation characteristics, including nanoformulation methodology or methodological variables such as surfactant, polymer, drug loading, and sonication times. Finally, we show the capacity of our database to produce correlations relating nanoparticle formulation parameters to biological outcomes, including nanotherapeutic impact on cell viability in cultured brain slices.
Selective aqueous ammonia sensors using electrochemical stripping and capacitive detection
Authors: Lalwani Anand V. , Dong Hang , Mu Linchao , Woo Kelly , Johnson Hunter A. , Holliday Max A. , Guo Jinyu , Senesky Debbie G. , Tarpeh William A. 
Published: September 2021

AbstractManaging waterborne ammonia–nitrogen pollution requires monitoring distributed wastewater nitrogen discharges. In this study, we demonstrated and investigated a proof‐of‐concept sensor that combines selective electrochemical separation and sensitive capacitive detection for sensing total ammonia nitrogen (TAN). By varying TAN concentration in synthetic ammonia‐polluted water (up to 50 mg/L), we selectively separated ammonia nitrogen from feedwater into a sulfuric acid solution, in which capacitance decreased linearly with increasing TAN (R2 > 0.99). Experimental observations were supported by theoretical explanations for the decrease in capacitance as ammonia absorbs into the sulfuric acid solution and abstracts protons. Capacitive detection facilitated TAN sensing at higher acid concentrations (up to 0.5 M H2SO4) than conductivity detection (up to 0.01 M H2SO4), which enables sensitive sensors with larger TAN detection ranges, longer deployment, and less complexity. Results from this study provide evidence of the use of selective separations and their transport mechanisms for environmental sensing applications.
In vivo and in vitro metabolism study of traditional Chinese medicine formula Dingkun Dan in rats by using ultra‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry
Authors: Dou Xiu‐xiu , Cai Ying‐li , Xu Xi‐ke , Zhang Yu‐hao , Guo Xin , Gao Zi‐qing , Lin Shan , Liang Yan‐lin , Ye Ji , Zhang Wei‐dong 
Published: September 2021

AbstractDingkun Dan (DKD), a reputable traditional Chinese medicine formula, has been used to treat gynecological diseases and showed significant clinical effects since ancient times. However, the application and development of DKD are seriously hampered by the unclear active substances. Structural characterization of compounds absorbed in vivo and their corresponding metabolites is significant for clarifying the pharmacodynamic material basis. In this study, an integrated strategy using ultra‐performance liquid chromatography, coupled with quadrupole time‐of‐flight mass spectrometry and UNIFI™ software, was used to identify prototypes and metabolites after oral administration of DKD in rats. As a result, a total of 261 compounds, including 140 prototypes and 121 metabolites, were tentatively characterized in rat plasma, urine, and feces. The metabolic pathways of prototypes have been studied to clarify their possible transformation process in vivo. Moreover, an in vitro metabolism study was applied for verifying the metabolites under simulating the metabolic environment in vivo. This first systematic metabolic study of DKD is important for elucidating the metabolites and metabolic pathways and could provide a scientific basis for explaining the integrative mechanism in further pharmacology study.
Expression levels of caspase‐3 and gasdermin E and their involvement in the occurrence and prognosis of lung cancer
Authors: Huang Yuan‐Li , Zhang Guang‐Hui , Zhu Qing , Wu Xia , Wu Li‐Gao 
Published: September 2021

AbstractBackgroundPyroptosis plays a dual role in the development of cancer and malignancy; as such, it may potentially be a new target for cancer treatment. However, the inflammatory response to pyroptosis may have adverse effects on the body. The roles of gasdermin E (GSDME), caspases, and related proteins associated with pyroptosis in cancer remain controversial.AimThe goal of this study was to determine whether the expression levels of caspase‐3 and GSDME affect the clinical stage, pathological grade, or survival prognosis of patients with lung cancer.MethodsWe examined the protein levels of GSDME, caspase‐3, caspase‐8, and caspase‐9 in lung tissue samples from 100 patients with lung cancer by using immunohistochemistry.ResultsWe found that GSDME, caspase‐3, and caspase‐8 were more highly expressed in tumor tissues than in adjacent normal tissues. Moreover, we found that GSDME could serve as a prognostic factor as there was a positive correlation between its expression level and the postoperative survival rate of patients with lung cancer.ConclusionsGSDME may be an independent factor affecting the prognosis of patients with lung cancer. However, the role of GSDME and its related proteins in cancer requires further research.
Amphilic Water‐Lean Carbon Capture Solvent Wetting Behavior through Decomposition by Stainless‐Steel Interfaces
Authors: Nguyen Manh‐Thuong , Grubel Katarzyna , Zhang Difan , Koech Phillip K. , Malhotra Deepika , Allec Sarah , Rousseau Roger , Glezakou Vassiliki‐Alexandra , Heldebrant David J. 
Published: September 2021

AbstractA combined experimental and theoretical study has been carried out on the wetting and reactivity of water‐lean carbon capture solvents on the surface of common column packing materials. Paradoxically, these solvents are found to be equally able to wet hydrophobic and hydrophilic surfaces. The solvents are amphiphilic and can adapt to any interfacial environment, owing to their inherent heterogeneous (nonionic/ionic) molecular structure. Ab initio molecular dynamics indicates that these structures enable the formation of a strong adlayer on the surface of hydrophilic surfaces like oxidized steel which promotes solvent decomposition akin to hydrolysis from surface oxides and hydroxides. This decomposition passivates the surface, making it effectively hydrophobic, and the decomposed solvent promotes leaching of the iron into the bulk fluid. This study links the wetting behavior to the observed corrosion of the steels by decomposition of solvent at steel interfaces. The overall affect is strongly dependent on the chemical composition of the solvent in that amines are stable, whereas imines and alcohols are not. Moreover, plastic packing shows little to no solvent degradation, but an equal degree of wetting.
Towards an optimal controllers' response time in a software‐defined network‐enabled data center
Authors: Janati Idrissi Mohamed , Raiss El‐Fenni Mohammed 
Published: September 2021

SummaryIn a digital world changing at high speed, data centers still play a major role in new network architectures. Software‐defined network (SDN) technology is considered as a suitable solution to solve and overcome several limitations of standard data centers including flexibility, scalability, and ease of management. However, in an SDN with a distributed control plane, the assignment of switches could be a cause of generating significant latency that could degrade the Quality of Experience (QoE) of certain services and applications hosted on the data center. In this paper, we propose a matching game algorithm ensuring a dynamic assignment of switches. Its main characteristic is to achieve a fair assignment while balancing the load generated by the data plane among all controllers resulting in a balanced response time. The numerical results show that our algorithm outperforms other existing state‐of‐the‐art algorithms in terms of minimizing controllers' response time.
Insights into the genetic regulatory network underlying neurogenesis in the parthenogenetic marbled crayfish Procambarus virginalis
Authors: Brenneis Georg , Schwentner Martin , Giribet Gonzalo , Beltz Barbara S. 
Published: September 2021

AbstractNervous system development has been intensely studied in insects (especially Drosophila melanogaster), providing detailed insights into the genetic regulatory network governing the formation and maintenance of the neural stem cells (neuroblasts) and the differentiation of their progeny. Despite notable advances over the last two decades, neurogenesis in other arthropod groups remains by comparison less well understood, hampering finer resolution of evolutionary cell type transformations and changes in the genetic regulatory network in some branches of the arthropod tree of life. Although the neurogenic cellular machinery in malacostracan crustaceans is well described morphologically, its genetic molecular characterization is pending. To address this, we established an in situ hybridization protocol for the crayfish Procambarus virginalis and studied embryonic expression patterns of a suite of key genes, encompassing three SoxB group transcription factors, two achaete–scute homologs, a Snail family member, the differentiation determinants Prospero and Brain tumor, and the neuron marker Elav. We document cell type expression patterns with notable similarities to insects and branchiopod crustaceans, lending further support to the homology of hexapod–crustacean neuroblasts and their cell lineages. Remarkably, in the crayfish head region, cell emigration from the neuroectoderm coupled with gene expression data points to a neuroblast‐independent initial phase of brain neurogenesis. Further, SoxB group expression patterns suggest an involvement of Dichaete in segmentation, in concordance with insects. Our target gene set is a promising starting point for further embryonic studies, as well as for the molecular genetic characterization of subregions and cell types in the neurogenic systems in the adult crayfish brain.
Midden site selection in Dorcas gazelle: Larger is not always better
Authors: Soultan Alaaeldin , Nagy Abdullah , Attum Omar 
Published: September 2021

AbstractDorcas gazelles are believed to use middens to mark their territories and transmit information. Given the commitment to maintaining a midden, it is believed that middens are not placed randomly. We examined how the habitat (tree height and maximum canopy) and anthropogenic disturbance (camel and human presence) influenced the selection of midden sites by Dorcas gazelles in South Sinai, Egypt. Our results showed that Dorcas gazelles did not place middens at larger trees, while favoring relatively smaller trees and shrubs where the anthropogenic disturbance and perceived hunting risk are less. Our results, in light of the previous findings, suggest that selection of midden sites is species context‐dependent behavior. In areas with less anthropogenic disturbance and hunting, Dorcas gazelles have been shown to select the largest trees of the same species as midden sites. In contract, in our study site with high anthropogenic disturbance and no protection from hunting, gazelles did not utilize the presumably optimum landmarks for midden sites. Our study showed that Dorcas gazelles instead utilized smaller trees and some shrubs that are less conspicuous and presumably less effective as advertisement sites, but safer.
Tracking the dynamic changes of a flavor, phenolic profile, and antioxidant properties of Lactiplantibacillus plantarum‐ and Saccharomyces cerevisiae‐fermented mulberry wine
Authors: Hu Jie , Vinothkanna Annadurai , Wu Meng , Ekumah John‐Nelson , Akpabli‐Tsigbe Nelson Dzidzorgbe Kwaku , Ma Yongkun 
Published: September 2021

AbstractThe process of fermentation renders the superior quality of mulberry wine based on the microorganisms utilized. The present study aimed at investigating the changes and correlation between phenols and product quality of mulberry wine fermented with Lactiplantibacillus plantarum and Saccharomyces cerevisiae combinatorially. Total anthocyanins concentration (TAC), polyphenols concentration (TPC), flavonoids concentration (TFC), and antioxidant capacity decreased significantly with high correlation in the fermentation process. TAC gradually reduced with a loss rate of 47.98% from 0 to third day of fermentation. Fermented mulberry wine obtained indicated a dynamic balance due to the presence of p‐hydroxybenzoic acids as compared to the primary phenolic constituent. Chlorogenic acid usually presents in mulberry juice. The relative intensity of sourness was the most prominent and reached the maximum (10.93) on day 2 of fermentation. A total of 21 volatile esters were quantified (6621.59 μg/L), which contributed significantly to the aroma of mulberry wine. The enhanced quality of fermented mulberry wine showed contraindications with decreased constituents and escalated wine quality. Rather than usual single inoculum, fermentation combination of LAB and yeast holistically influenced the color, taste, fragrance, phenolic profiles, and antioxidant properties in mulberry wine, ensuring palatability and fit for commercialization prospects.
Considering context in information systems research: Understanding the conditions of developing country scholarship
Authors: Ramadani Luthfi , Almaarif Ahmad 
Published: September 2021

AbstractResearch on information systems (IS) in developing countries focuses on understudied contexts that recent scholars believe have the potential to provide new knowledge. However, the extant discussion on this endeavor rarely considers IS scholars inside the developing countries who could be the ideal discoverers of such context‐specific knowledge. In this study, we review the facilitating conditions of the discovery of new theories to examine IS research in the case of Indonesia. We then interview experienced Indonesian IS scholars to develop a richer understanding of the IS scholarship's conditions. We found that while considering and theorizing context have been interests by a small group, the extant efforts are intertwined by the lack of exposure to myriad research epistemology/methodology, the infancy state of IS as a discipline, and the tendency to address convenient rather than crucial research questions, all of which are manifested in a complex institutional environment. We then provide important pathways and future agendas to strengthen and advance IS scholarship in developing countries.
CuI/L‐proline‐catalyzed synthesis of bis(2‐(4,5‐diaryl‐1H‐imidazol‐2‐yl)phenyl)sulfane derivatives using potassium ethylxanthate as a sulfur source
Authors: Zhang Yan , Li Tuan‐Jie , Lv Lanlan , Liu Jian‐Quan , Wang Xiang‐Shan 
Published: September 2021

AbstractA CuI/L‐proline‐catalyzed reaction of 2‐(2‐bromophenyl)‐4,5‐diaryl‐1H‐imidazole and potassium ethylxanthate unexpectedly gave bis(2‐(4,5‐diaryl‐1H‐imidazol‐2‐yl)phenyl)sulfane derivatives in high yields, rather than 2,3‐diphenyl‐5H‐benzo[e]imidazo[1,2‐c]thiazine‐5‐thione. This cascade procedure provided an efficient method to synthesize diphenylsulfanes using potassium ethylxanthate as a new type of sulfur source via the Csp2S bond Ullmann reaction twice.
Reproducibility of Longitudinal Changes in Cortical Thickness Determined by Surface‐Based Morphometry Between Non‐Accelerated and Accelerated MR Imaging
Authors: Takao Hidemasa , Amemiya Shiori , Abe Osamu ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: September 2021

BackgroundScan acceleration such as parallel imaging reduces scan time, but shorter scan time may reduce the signal‐to‐noise ratio and affect image quality. The reproducibility of longitudinal changes in the brain structure between non‐accelerated and accelerated imaging by surface‐based analysis is unclear.PurposeTo determine the reproducibility of longitudinal changes in cortical thickness, measured by surface‐based morphometry, between non‐accelerated and accelerated structural T1‐weighted imaging in the healthy elderly and those with mild cognitive impairment (MCI) and Alzheimer's disease (AD).Study TypeRetrospective.SubjectsFifty healthy elderly subjects (age = 73 ± 5 years, 29 females, 21 males), 54 MCI patients (age = 71 ± 7 years, 23 females, 31 males), and 8 AD patients (age = 78 ± 6 years, 6 females, 2 males).Field Strength/Sequence3 T, magnetization‐prepared rapid gradient‐echo.AssessmentLongitudinal changes in cortical thickness estimated by the longitudinal stream in FreeSurfer from 2‐year interval data, and visual assessment of image quality by three radiologists.Statistical TestsIntraclass correlation coefficient (ICC) and Kruskal–Wallis test. A P value <0.05 was considered significant.ResultsHealthy elderly subjects, MCI patients, and AD patients showed different patterns in the ICC maps. For the smoothing of 20 mm full width at half maximum, the mean ICC was 0.45 overall (healthy elderly, 0.33; MCI patients, 0.49; AD patients, 0.31). The within‐subject SDs of the symmetrized percent changes were similar between healthy elderly subjects (mean, 1.3%/year) and MCI patients (mean, 1.3%/year) but larger in AD patients (mean, 1.7%/year). Image quality did not significantly differ per group (P = 0.18).Data ConclusionThe results of this study indicate the reproducibility of longitudinal changes in cortical thickness measured by surface‐based morphometry between non‐accelerated and accelerated imaging, and that the reproducibility varies by disease and region.Level of Evidence3Technical EfficacyStage 1
Safely performing percutaneous dilatational tracheostomies on COVID‐19 patients in the intensive care unit: A standardized approach
Authors: Tenório Lucas Ribeiro , Nakai Marianne Yumi , Artese Araújo Giancarlo , Menezes Marcelo Benedito , Bertelli Antônio Augusto Tupinambá , Romeo Dominic , Rajasekaran Karthik , Gonçalves Antonio José 
Published: September 2021

AbstractBackgroundSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and the resulting coronavirus disease 2019 (COVID‐19) have afflicted hundreds of millions of people in a worldwide pandemic. During this pandemic, otolaryngologists have sought to better understand risk factors associated with COVID‐19 contamination during surgical procedures involving the airways such as tracheostomies.ObjectiveThis study provides a standardized technique of performing an ultrasound (US)‐guided percutaneous dilatational tracheostomy (PDT) on COVID‐19 patients in the intensive care unit (ICU). It also outlines safety strategies for health care providers that includes proper use of personal protective equipment (PPE) and regular testing of otolaryngologists for COVID‐19 contamination.MethodsThis study analyzed data from 44 PDT procedures performed on COVID‐19 patients in the ICU of hospitals in Sao Paulo and Santos, Brazil. The PDT procedures were conducted between April 2020 and August 2020, which coincided with a peak of the COVID‐19 pandemic in São Paulo, Brazil. Surgeons were tested for COVID‐19 using a two‐stage serological enzyme‐linked immunosorbent assay specific for SARS‐CoV‐2 antigens.ConclusionThis study describes a safe standardized technique of US‐guided PDT for COVID‐19 patients in the ICU using a method that also decreases the risk of surgeon contamination.
Healthcare needs of people living with human immunodeficiency virus: A qualitative descriptive study
Authors: Ibrahim Kusman , Herliani Yusshy Kurnia , Rahayuwati Laili , Khadijah Siti , Sutini Titin 
Published: September 2021

AbstractAimA better understanding about the health care and support needs is beneficial to maintain the linkage between People Living with Human Immunodeficiency Virus (PLWH) and healthcare services. This study aims to explore the healthcare needs of PLWH from their perspectives.DesignA qualitative descriptive study design was undertaken in July 2017 to June 2018.MethodsFourteen participants were recruited by purposive sampling technique. Face‐to‐face in‐depth interview and focus‐group discussion (FGD) were conducted and analysed using content analysis.ResultsData revealed five themes, namely the needs to be free from stigma and discrimination, strengthen life spirit, have safe sexual practices, social support, and have accessible and affordable healthcare services.ConclusionPeople Living with Human Immunodeficiency Virus have their own perspectives on their healthcare needs. Therefore, nurses and other healthcare providers need to explore, understand, and respond to the needs, and incorporate them into comprehensive and holistic care.