bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bletilla striata Polysaccharide Cryogel Scaffold for Spatial Control of Foreign-body Reaction
Authors: Chen Jiaxi , Zhou Huiqun , Xie Daping , Niu Yiming 
Published: October 2021

Abstract
BackgroundImplantation of a biomaterial may induce the foreign-body reaction to the host tissue that determines the outcome of the integration and the biological performance of the implant. The level of foreign-body reaction can be modulated by material properties.MethodsFirst, we synthesized methacrylated Bletilla striata Polysaccharide (BSP-MA) and constructed a series of open porous cryogels utilizing this material via the freezing-thawing treatment of solvent-precursors systems. Second, Pore size and rheology were measured to characterize the material properties of cryogels. Live/dead staining of cells and CCK-8 was performed to test the cytocompatibility of the scaffolds. In addition, the Real-Time qPCR experiments were carried for in vitro tests. Finally, the BSP scaffolds were implanted subcutaneously to verify the foreign-body reaction between host tissue and materials.ResultsOur data demonstrated that cryogels with different pore sizes and modulus can be fabricated by just adjusting the concentration. Besides, the cryogels show well cytocompatibility in the in vitro experiments and exhibited upregulated expression levels of pro-inflammation-related genes (Tnfa and Il1b) with the increase of pore size. In vivo experiments further proved that with the increase of pore size, more immune cells infiltrated into the inner zone of materials. The foreign-body reaction and the distribution of immune-regulatory cells could be modulated by tuning the material microstructure.ConclusionsCollectively, our findings revealed Bletilla striata polysaccharide cryogel scaffold with different pore sizes can spatially control foreign-body reaction. The microstructure of cryogels could differentially guide the distribution of inflammatory cells, affect the formation of blood vessels and fibrous capsules, which eventually influence the material-tissue integration. This work demonstrates a practical strategy to regulate foreign body response and promote the performance of medical devices.
Role of Natural and Synthetic Flavonoids as Potential Aromatase Inhibitors in Breast
Cancer: Structure-Activity Relationship Perspective
Authors: Shah Umang , Patel Aarti , Patel Samir , Patel Mehul , Patel Ashish , Patel Swayamprakash , Patel Sandip , Maheshwari Rajesh , Mtewa Andrew G , Gandhi Karan 
Published: October 2021

Abstract:
World Health Organization categorized breast cancer as one of the leading cancer types in females worldwide,
and its treatment remains challenging. Accumulated evidence suggested the role of estrogen and its metabolites
in pre- and post-menopausal women.
Upregulation of estrogen-dependent aromatase is significantly involved in the pathogenesis of breast cancer. Several
aromatase inhibitors, such as exemestane, formestane, and letrozole, are being used clinically, owing to their estrogen
suppression role. Apart from these drugs, several other molecules, such as natural and synthetic flavonoids, have been
reported widely for a similar biological activity. However, some reasonable modifications are required for these structures
to achieve desired efficacy and to alleviate toxicity. Designing a novel aromatase inhibitor will be possible if we
can establish a rational correlation between the chemistry and biological features of the existing molecules. The benzopyranone-
ring system, present in the flavonoid molecules, has been reported as a pharmacophore due to its inhibitory
activity on aromatase, which helps repress breast cancer progression. This essential feature has been utilized to modify
several natural flavonoids into 5 and 7 hydroxy/methoxy flavone, 4-imidazolyl/triazolyl flavone, 5,4’- diamino flavone,
7,8- benzo-4-imidazolyl flavone, α-naphthoflavone, and 2-azole/thiazolyl isoflavone derivatives. These scaffolds have
been considered in this review for meticulous study in aspects of the structure-activity relationship for aromatase inhibitory
activity, and it would likely pave the way for designing a potential lead candidate in the future.
Theoretical Tire Model for Wear Progress of Tires with Tread Pattern Considering Two-Dimensional Contact Patch
Authors: Nakajima Yukio , Hidano Shunya 
Published: October 2021

ABSTRACT
A new theoretical tire model for the wear progress of tires with tread block pattern is developed considering a two-dimensional contact patch. In the model, the wear energy is calculated from the shear force and pressure distribution in a two-dimensional contact patch that are changed with not only shear forces in a contact patch but also with the wear and irregular wear of tires. The fore–aft shear force in a contact patch consists of six mechanisms related to slip ratio, camber, contact between a tire and a road, barrel deformation of a loaded block, rolling resistance, and a rolling tire with rounded crown shape, whereas the lateral shear force consists of three mechanisms related to slip angle/camber, contact of a tire with rounded crown shape, and barrel deformation of a loaded block. The heel and toe irregular wear and the progress of irregular wear under pure slip condition qualitatively agree with the conventional knowledge of tire engineers. The expected wear energy is introduced to predict the wear progress under combined slip condition in the wear course. Using the vehicle dynamics to predict the tire force history, a histogram of external forces is obtained by transforming from it. Calculating wear energies by changing slip angle and slip ratio, the relation between external forces and the wear energy is expressed as the response surface. Multiplying the wear energy by the histogram, the expected wear energy distribution in a block is calculated. Assuming that the worn depth is proportional to the expected wear energy, the wear progress is predicted.
40 Years and More of Tire Science and Technology: A History of The Tire Society
Authors: McIntyre James E. 
Published: October 2021

ABSTRACT
In the late 1960s in the United States, public interest in motor vehicle safety was at an all-time high, resulting in the National Traffic and Motor Vehicle Safety Act, the Highway Safety Act, and the creation of the National Highway Traffic Safety Administration. Around 1970, a group of industry scientists saw a need for a forum for creation of useful tire standards and dissemination of scientific knowledge about tires. This led to the formation of the American Society for Testing and Materials (ASTM) Committee F-09 on tires in 1971. In 1972, the committee began publication of the journal Tire Science & Technology (TSTCA), the first peer-reviewed journal dedicated exclusively to scientific articles on tires. In 1979, ASTM ceased publication of the journal, and in 1980, members of F-09 incorporated The Tire Society to continue publication. In 1982, The Tire Society held its first annual Conference on Tire Science and Technology. Nearly 40 years later, the society has been through many changes, but the journal, the annual conference, and the core mission of encouraging and disseminating knowledge about tire science and technology remain. Through a review of documents and interviews with members of the society, this article seeks to comprehensively document the history of The Tire Society.
Comprehensive Grounding Performance Evaluation of Tires Based on the Analytic Hierarchy Process
Authors: Liang Chen , Liu Hao , Zhu Daqian , Wang Guolin 
Published: October 2021

ABSTRACT
The contact patch between tire and road surface has a direct impact on tire grounding performance. Acquiring tire grounding performance either by testing or simulation is not only time intensive but comes at a high cost. This paper proposes an effective means of evaluating tire grounding performance based on the tire-ground contact pressure distribution. This paper adopts fifteen characteristics to describe the tire-ground contact patch in which twelve structural schemes were designed for a certain type of tire. By using the simulation test method, the grounding performance characteristics such as grip performance, rolling resistance, wear performance, and the tire footprint characteristics were obtained. Correlation analysis was used to explore the relationship between tire grounding performance and footprint characteristics. Based on the correlation analysis and expert judgement, the analytic hierarchy process (AHP) model for comprehensive grounding performance evaluation of a tire was constructed. Then judgment matrix of the AHP model was established, and the consistency or otherwise of the judgment matrix was verified. The model was then used to evaluate and predict the four design schemes of tires. The evaluation results were in good agreement with the simulation test results, which shows that the construction method of the tire comprehensive grounding performance evaluation system proposed in this paper is practical. It is also evident that grounding performance evaluation of a tire based on the tire footprint is feasible.
Meningkatan Kemampuan Pukulan Chudan Tsuki dengan Menggunakan Metode Latihan Pull Up pada Dojo Karate Club Kajen Kabupaten Pekalongan
Authors: Prabowo Lumeinthank Ade , Setyawan Danang Aji , Ratimiasih Yulia 
Published: October 2021

Tujuan penelitian untuk mengetahui pengaruh latihan variasi Pull Upterhadap peningkatan kemampuan pukulan chudan tsuki serta kondisi fisik atlet. Metode penelitian yang digunakan adalah penelitian eksperimen dengan teknik pretest, treatment, posttest. Populasi dalam penelitian ini pada dojo Karate Club Kajen Kabupaten Pekalongan dengan jumlah sampel 18 atlet terdiri dari 7 putri dan 11 putra. Analisis data menggunakan perhitungan statistic dihitung menggunakan SPSS 22,0 dengan asumsi Uji Normalitas, Uji Homogenitas, Uji Hipotesis (uji t). Hasil penelitian diperoleh rata-rata hasil pretest kemampuan pukulan Chudan Tsukisebelum diberikan treatment (latihan Pull Up) adalah 9,6111 (36%) dengan data (varian) 2,016 dan simpangan baku (standar deviasi) 1,41998. Sedangkan rata-rata hasil posttest kemampuan pukulan Chudan Tsukisetelah diberikan treatment (latihan Pull Up) adalah 17,111 (64%) dengan keragaman data (varian) 6,810 dan simpangan baku (standar deviasi) 2,60969. Maka terjadi peningkatan pukulan Chudan Tsukisebesar 28%. Deskripsi hasil treatment (latihan Pull Up) diperoleh skor rata-rata lebih dari 10 dimana skor terendah sebesar 13 dan skor tertinggi 27. Secara keseluruhan selama 16 kali pertemuan terjadi naik turun (flukuatif) hasil skornya. Berdasarkan dari tujuan penelitian dan hasil penelitian yang telah diuraikan diatas, maka diperoleh kesimpulan bahwa pemberian latihan Pull Up berpengaruh dalam meningkatkan kemampuan pukulan Chudan Tsuki. Pada hasil penelitian menyarankan untuk dapat memasukan latihan Pull Up dalam program latihan karate dan menyediakan sarana dan prasarana yang lebih baik agar atlet dapat berlatih secara efektif dan semangat ntuk berlatih.
IMPLEMENTASI MODUL PENJASORKES BERMUATAN MODEL PEMBELAJARAN BANDURA UNTUK MENINGKATKAN HASIL BELAJAR PENJASORKES DAN KECERDASAN KINESTETIK SISWA SEKOLAH DASAR
Authors: Yoda I Ketut 
Published: October 2021

Penelitian bertujuan untuk mengimplementasikan modul penjasorkes bermuatan model pembelajaran Bandura dalam meningkatkan hasil belajar penjasorkes dan kecerdasan kinestetik siswa sekolah dasar. Populasi dalam penelitian ini adalah siswa SD Laboratorium kelas IV. Penelitian ini menggunakan metode eksperimen semu dengan teknik pengambilan sampel random sampling. Jumlah sampel yang digunakan satu kelas yang berjumlah 29 orang. Analisis data dilakukan secara deskriptif dengan cara menyusun data secara sistematis, mengorganisasi data ke dalam kategori, melakukan sintesa, menyusun dalam pola tertentu, dan membuat kesimpulan. Hasil analisis data di peroleh bahwa modul penjasorkes bermuatan model pembelajaran Bandura yang diterapkan di kelas IV Sekolah Dasar Laboratorium Undiksha Singaraja menunjukkan hasil belajar yang baik dengan peningkatan kecerdasan kinestetik juga baik. Respon siswa menunjukkan bahwa 100% siswa menyatakan modul penjasorkes bermuatan model pembelajaran Bandura dapat dengan mudah dipahami dalam melatih keterampilan gerak dan kecerdasan kenestetis siswa.
In Vitro Thermal Requirements of Some Beauveria sp. Isolates Under Constant Conditions
Authors: Cristina Fătu Ana , Maria Lumînare Cristina , Nicolae Cojanu Daniel , Monica Dinu Mihaela , Maria Andrei Ana 
Published: October 2021

The thermal tolerance of four isolates of Beauveria bassiana and one isolate of Beauveria pseudobassiana was evaluated in vitro, by measuring the colonial diameters, on PDA medium, at temperatures between 5 and 35 ° C, during 14 days. The data obtained were used to calculate the growth rate of fungal colonies (mm / day), using linear regression. The representation of the values corresponding to the minimum, optimal and maximum temperature for vegetative growth was a curve described by a modified beta (ß) mathematical function. The minimum growth temperature of these isolates varied between 3.4 and 4.5 °C, the optimum temperature varied between 21.8 and 22.9 °C, except for one isolate of which optimal temperature was 26.8 °C, while the maximum temperature was varied for all isolates between 35.0 and 35.7 °C.
Theoretical Study for the Calculation of Proton Range in Human Body Tissues
Authors: Hadi Shaima M. , Saied Bashair M. 
Published: October 2021

The main rationale for using charged particles in radiation therapy is the strong rise of energy loss (deposited dose) with maximum penetration depth ( Bragg peak) and rapid dose deposited behind the peak. Thus, a large dose can be applied to a deep seated tumor, with saving the surrounding normal tissues . Proton radiotherapy is nowadays an established method in the management of cancer diseases, although its availability is still limited to a few specialized centers. In this study, the range and the stopping power for proton interaction in the skeleton and intestine tissues, for an energy range from 0.01 to 300 MeV, was studied. The numerical calculations and analyses of Bethe Ziegler, along with CASP and SRIM software programs, were applied using Matlab program. The absorbed dose and the Bragg peak were calculated and presented as tables and figures .
Caring and Conflict-Palliative Care in the Armed Forces: The Challenges for Caregivers
Authors: Butola Savita , Bhatnagar Sushma , Rawlinson Fiona 
Published: October 2021

Objectives:
In India, Palliative care remains inaccessible, especially in remote areas. This study aimed at exploring the experience of caregivers related to arranging palliative care at home, for personnel and family members of an armed force.

Materials and Methods:
Qualitative study based on thematic analysis of semi-structured interviews with adult caregivers - either serving personnel or their dependent family members.

Results:
Lack of palliative care in rural areas makes arranging home care challenging for Indian caregivers, especially in armed forces. The families stay alone and personnel cannot be there to look after loved ones. Constraints of leave, financial and legal problems, frequent movement and social isolation disrupt care as well as family and community support systems, leading to psycho-social problems and stress for the serving personnel as well as families. Educating staff, integrating palliative care into existing medical services, coordinating with other agencies to increase awareness and provide care at home, access to opioids, timely leave, reimbursement of expenses, increased family accommodation, guidance about benefits, and considerate implementation of transfer policy can help mitigate some of their problems.

Conclusion:
These caregivers face physical exhaustion, psycho-social, financial, legal, and spiritual issues- some common to all rural Indians and others unique to the armed forces. Understanding their experiences will help the providers find solutions, especially in relation to the unique needs of the men in uniform.
ASSOCIATION OF EDUCATION AND HOUSING QUALITY WITH PUBLIC HEALTH EVENTS OF NATIONAL SIGNIFICANCE IN EIGHT MUNICIPALITIES OF CALDAS - COLOMBIA
Authors: Gonzalez Ricardo , Bermont Gerson , CárdenasAlzate Pedro Pablo 
Published: October 2021

A questionnaire called “Family sheet” was created to collect information about the population of the Department of Caldas – Colombia.
Method: Analytical cross-sectional study using information from these questionnaires and the Colombian National System of Public Health Surveillance
Results: A total of 1735 public health events of national significance were found. The most common levels of education were “secondary education” and “Pre-school or primary education”. Most of the dwellings had “safe and adequate water supply”, “sanitary disposal of excreta”, adequate “structural features and furnishing”, and “appropriate “lighting”. Their “disposal of solid wastes, and personal and domestic hygiene” was fair and they did not have “indoor air pollution” or “Overcrowding”. Statistically significant associations were found of some levels of education with chickenpox, zika virus disease, foodborne diseases, external causes of injuries and fluoride exposure. They were also identified between “safe and adequate water supply” and/or “sanitary disposal of excreta” and dengue, chikungunya y leishmaniasis; “structural features and furnishing” and fluoride exposure, and “Overcrowding” and Violence against women, domestic and sexual violence/gender-based violence. However, the predictive value of these variables was weak.
Conclusions: The distribution of studied variables was similar to previous studies and some statistically significant associations were found; however, their predictive value was weak.
Qu'est-ce qui amène un empereur romain, un des diplomates les plus doués du monde, une reine destituée et un empereur médiéval à Bernex?
Authors: Arregui Alexandre Zielinsky , Lima Marcia Rosa de 
Published: October 2021

O interesse pela herança cultural e arqueológica versus o desenvolvimento econômico e corporativo. Qual subsiste?
O presente trabalho foi circulado junto à diversos atores do vilarejo de Bernex no cantão de Genebra na Suíça, bem como indivíduos da comunidade arqueológica local, e do Vaticano.
O intuito fora de trazer a conscientização da preservação de um importante sítio arqueológico (romano, baixa e alta idade média) frente ao projeto de expansão demográfico da cidade de Genebra, e a conseqüente destruição dessa área em detrimento da exploração imobiliária, e a construção de cinco torres de apartamentos residenciais e comerciais no local.
A rica história e os inúmeros vestígios da área destruída, que incluem cemitérios com centenas de restos mortais humanos, suscita muitos questionamentos, e nos fazem refletir sobre o quão frágil é a tensão entre o interesse político e económico do desenvolvimento, e o apagamento (ou pulverização gradual) da memória cultural atrelada à área que deixa de existir.
O caminho apontado para uma possível atenuação das conseqüências da destruição do sítio, seria a integração do material arqueológico encontrado no local, nos edifícios, ou até mesmo em passeios públicos (praças) que vão integrar o projeto urbanístico da área.
Aktivitas antibakteri ekstrak bawang merah mixture pasta gula pada Staphylococcuc aureus
Authors: Tahiruddin Tahiruddin , Indriastuti Diah 
Published: October 2021

Pendahuluan:Terdapat berbagai produk alami yang secara empiris telah digunakan sebagai obat tradisional dalam penyembuhan luka. Bawang merah (Allium cepa) dan gula merupakan bahan alami dalam penyembuhan luka. Tujuan: mengetahui daya hambat ekstrak bawang merah mix pasta gula terhadap pertumbuhan bakteri Staphylococcus aureus secara in vitro. Metode: menggunakan desain eksperimental dengan tiga kali pengulangan. Sampel pada penelitian ini adalah bakteri Staphylococcus aureus, bawang merah, icing sugar, dan castor sugar. Hasil:zona hambat lebih besar pada konsentrasi 100% ulangan ke-1, yaitu 22,87 mm. Simpulan:Sebagai antibakteri pada penyembuhan luka, bawang merah efektif menghambat mikroba dan gula bekerja secara osmotik, sehingga perlu dikembangkan menjadi topikal dalam penyembuhan luka.
Psychoanalyse als gesellschaftliche Institution
Authors: Schülein Johann August 
Published: October 2021

Die Psychoanalyse in ihrer Tragweite zu verstehen, bedeutet auch, ihr gesellschaftliches Fundament freizulegen. Speziell soziologische Perspektiven eröffnen dabei vielfältige Möglichkeiten, das (Selbst-)Verständnis der Psychoanalyse zu vertiefen und sie – stärker als bisher – in ihrer Bedeutung und Wirkmächtigkeit als soziale Institution zu begreifen.

Mit wissenssoziologischem, institutions- und erkenntnistheoretischem Blick spürt Johann August Schülein der Art und Weise nach, wie psychoanalytisches Denken konkret in komplexe psychische und soziale Prozesse eingreift und dialogisch mit ihnen verbunden ist. Anhand historischer Momente der Entwicklung und Schulenbildung der Psychoanalyse sowie im Rückgriff auf ihre Fähigkeit zu Sozialdiagnose und Gesellschaftskritik profiliert Schülein anschaulich die kooperative Anschlussfähigkeit der Psychoanalyse in den Sozialwissenschaften.
STRATEGI PENANGANAN KAWASAN PEMUKIMAN KUMUH DI KELURAHAN TANAH DATAR KECAMATAN PEKANBARU KOTA KOTA PEKANBARU
Authors: Marni Dewi , Siregar Sofyan Husein , Suprayogi Imam 
Published: October 2021

The development of slums in urban areas is inseparable of the increases in population and population activity. In addition, undirected and unplanned development also supports the degradation of the quality of residential environment. One area that is included in the slum area is located in Tanah Datar Sub-District. The residential area of Tanah Datar Sub-District is right in the heart of Pekanbaru city. Thus, living conditions and the welfare of the people who live in these settlements greatly affect the face of a city. The characteristics and conditions of slums in each region is different. Thus, this study aims to identify the condition of a residential area in order to determine alternatives to handling slum areas appropriately. The method used is exploratory descriptive of phenomena and facts relating to the condition of the community and the environment of slum areas based on real facts, expert opinion and the criteria of the Minister of PUPR Regulation Number 14/PRT/M/2018. The results showed that in achieving the goal of handling slum areas, the priority of government policy and budget allocation alignments be the most important factor. Then, strengthen government collaboration with relevant stakeholders and handling based on the priority scale required by the residential area.
Observación del plan de vacunación del COVID-19 en Colombia
Authors: Díaz Pinzón Jorge Enrique 
Published: October 2021

Introducción: Desde la identificación de los primeros casos de enfermedad por coronavirus 2019 (COVID-19) originada por el síndrome respiratorio agudo severo coronavirus 2 (SARS-CoV-2) en diciembre de 2019, la pandemia resultante ha dado lugar a más de 210 millones de casos confirmados de COVID-19. y más de 4,4 millones de muertes en todo el mundo al 6 de abril de 2021. Objetivo: mostrar el comportamiento del plan de vacunación contra el SARS-COV-2, entre el periodo comprendido entre el 17 de febrero al 17 de agosto de 2021. Metodología: La presente investigación se efectuó bajo un estudio transversal, como fuente de información se adquirió de la página del plan de vacunación nacional contra el COVID-19 de la página web del Ministerio de Salud y Protección Social. Resultados: al día 6 de agosto se evidencio el mayor número de aplicaciones diarias con 594.993 dosis, para el 29 de junio se observó el mayor número de segunda dosis aplicadas con 235.048, el 15 de julio se produjo el mayor número de monodosis aplicadas con 165.266 dosis, y el 9 de julio se presentó el mayor número de esquemas completos con 337.354. Conclusión: Es de vital importancia realizar un seguimiento al proceso de vacunación para entender su eficacia, la posible disminución de la respuesta inmune con el tiempo y los posibles efectos adversos.

Palabras clave: COVID-19, SARS-CoV-2, pandemia, vacunas.