bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kegiatan Hubungan Internal Melalui Human Relations
Authors: Rahman Saeful , Rahman Saeful 
Published: May 2021

ABSTRAK
Tujuan penlitian kegiatan hubungan internal melalui human relations pada PT. Dias Design Consult adalah untuk mengetahui bagaimana pimpinan perusahaan menjalankan prinsip-prinsip human relations dalam hubungan internal, agar terciptanya hubungan yang harmonis dalam perusahaan secara efektif dan efisien. Penelitian ini menggunakan metode penelitian kualitatif dengan pendeketan studi kasus dan paradigma konstruktivstik. Hasil penelitian dengan menggunakan konsep POAC (Planning, Organizing, Actuating, Controling) pimpinan perusahaan dalam melakukan kegiatan hubungan internal melalui human relations dalam menjaga, meningkatkan, memelihara dan membangun hubungan harmonis dalam publik internal menerapkan prinsip-prinsip hubungan antar manusia dengan kegiatan hubungan antar mansuia yang bersifat memberikan kenyamanan dan kepuasan hati melalui perkumpulan keluarga, bonus tahunan, pujian dan konseling.
Kata Kunci : Hubungan Internal; Human Relations; Public Relations
ABSTRACT
The purpose of researching internal relations activities through human relations at PT. Dias Design Consult is to find out how company leaders carry out the principles of human relations in internal relations, in order to create harmonious relationships within the company effectively and efficiently. This study uses qualitative research methods with a series of case studies and constructive paradigms. The results of the study using the concept of POAC (Planning, Organizing, Actuating, Controling) company leaders in carrying out internal relations activities through human relations in maintaining, improving, maintaining and building harmonious relationships in the internal public apply the principles of human relations with activities between human relations which is to provide comfort and satisfaction through family gathering, annual bonuses, praise and counseling.
Keywords : Internal Relations: Human Relations; Public Relations
Manajemen Strategi LAZISMU Jawa Barat dalam Mengelola Dana Zakat
Authors: Diana Syafitri Diana Syafitri , Sarbini Ahmad , Yuliani Yuliani 
Published: May 2021

Penelitian ini bertujuan untuk mengetahui bagaimana manajemen strategi di LAZISMU Jawa Barat, khususnya dalam mengelola dana zakat. Penelitian ini bertolak dari pemikiran Riva’i dalam Eddy Yunus bahwa manajemen strategi yang terdiri dari tiga proses yaitu: (1) Perumusan strategi, (2) Penerapan strategi, (3) Evaluasi. Metode yang digunakan dalam penelitian ini adalah metode deskriptif. Teknik pengumpulan data dengan observasi dan wawancara. Berdasarkan temuan ini dapat disimpulkan bahwa manajemen strategi di LAZISMU Jawa Barat terdiri dari tiga proses: Pertama, perumusan strategi yang meliputi perumusan visi dan misi, analisis lingkungan, menentukan tujuan dan sasaran serta berakhir dengan penentuan strategi. Kedua, penerapan strategi yang meliputi pengorganisasian, sinergi fungsional yang mengatur pelaksanaan program, dan prosedur program pengelolaan dana zakat mulai dari pengumpulan, pendistribusian serta pendayagunaan zakat produktif. Ketiga, evaluasi strategi dari proses perumusan dan penerapan strategi.
This study aims to determine how strategic management in LAZISMU West Java, especially in managing zakat funds. This research is based on Riva'i's thought in Yunus that strategic management consists of three processes, namely: (1) strategy formulation, (2) strategy implementation, (3) evaluation. The method used in this research is descriptive method. Data collection techniques by observation and interviews. Based on these findings, it can be concluded that strategic management in LAZISMU West Java consists of three processes: First, the formulation of a strategy which includes the formulation of a vision and mission, environmental analysis, determining goals and objectives and ending with determining the strategy. Second, the implementation of strategies that include organizing, functional synergy that regulates program implementation, and program procedures for zakat fund management starting from the collection, distribution and utilization of productive zakat. Third, evaluation of strategies from the process of strategy formulation and implementation.
Dietary Soy Protein Effects on Inherited Polycystic Kidney Disease Are Influenced by Gender and Protein Level
Authors: AUKEMA HAROLD M. , HOUSINI IHSAN , RAWLING JEAN M. 
Published: May 2021

Abstract.
The effects of dietary soy protein compared to casein were examined in male and female CD1-pcy/pcy (pcy) mice with polycystic kidney disease. Animals 10 wk of age were fed purified diets containing either soy protein isolate or casein given at a level of 17.4 or 6% protein. After 13 wk on the diets, body weights and serum concentrations of albumin and protein indicated that protein nutrition was adequate on all diets. Overall, animals fed soy protein versus casein had 28% lower (P = 0.0037) relative kidney weights (g/100 g body wt), 37% lower (P = 0.0089) cyst scores (% cyst area × relative kidney weight), and 25% less (P = 0.0144) kidney water (g). Dietary protein reduction resulted in 30% lower (P = 0.0010) relative kidney weights, 25% lower (P = 0.0327) cyst scores, and 35% less (P = 0.0001) kidney water. Analysis of interactions between main effects revealed that the effects of soy protein on kidney size were significant only in females, and that effects of soy protein on cyst score were significant only in animals on the low protein diets. In addition, differences in kidney weights and cyst score due to protein reduction were significant in animals fed soy protein, but not in those fed casein as the protein source. These results show that both dietary protein source and level significantly affect polycystic kidney disease in pcy animals, with the effects of dietary soy protein being most pronounced in female animals fed the low protein diets and the effects of protein reduction being most pronounced in animals fed soy protein-based diets.
A Large Subset of Neutrophils Expressing Membrane Proteinase 3 Is a Risk Factor for Vasculitis and Rheumatoid Arthritis
Authors: WITKO-SARSAT VERONIQUE , LESAVRE PHILIPPE , LOPEZ SANDRA , BESSOU GILLES , HIEBLOT CORINNE , PRUM BERNARD , NOËL LAURE HÉLÈNE , GUILLEVIN LOÏC , RAVAUD PHILIPPE , SERMET-GAUDELUS ISABELLE , TIMSIT JOSE , GRÜNFELD JEAN-PIERRE , HALBWACHS-MECARELLI LISE 
Published: May 2021

Abstract.
It has been shown previously that proteinase 3 (PR3), a neutrophil intracellular protease that is the main antigen of antineutrophil cytoplasm (ANCA) autoantibodies, is present on the plasma membrane of a subset of freshly isolated neutrophils. This study shows that the size of this subset of membrane PR3-positive (mPR3+) neutrophils is a stable feature of a given individual, most likely genetically controlled. It ranges from 0 to 100% of neutrophils and allows us to define a new polymorphism in the healthy population, with three discrete phenotypes corresponding respectively to less than 20% mPR3+ neutrophils (mPR3low) or to a mean percentage of 47% (mPR3intermediate) and 71.5% (mPR3high) mPR3+ neutrophils. The frequency of the mPR3high phenotype was significantly increased in patients with ANCA-associated vasculitis (85% versus 55% in healthy subjects). The percentage of mPR3+ neutrophils was not affected by disease activity, relapses, or therapy, and did not reflect in vivo cell activation. In addition, mPR3+ phenotypes were normally distributed in cystic fibrosis patients, indicating that infection and/or inflammation per se do not lead to a high percentage of mPR3+ neutrophils. The frequency of the mPR3high phenotype was not related to anti-PR3 autoimmunization, since it was increased in vasculitic patients regardless of the ANCA specificity (anti-PR3, anti-myeloperoxidase, or unknown). Interestingly, the frequency of the mPR3high phenotype was also increased in patients with rheumatoid arthritis. It was normal in type I-diabetes, a T cell-dependent autoimmune disease. It is proposed here that a high proportion of membrane PR3-positive neutrophils could favor the occurrence or the progression of chronic inflammatory diseases.
Unrecognized Pattern of von Willebrand Factor Abnormalities in Hemolytic Uremic Syndrome and Thrombotic Thrombocytopenic Purpura
Authors: GALBUSERA MIRIAM , BENIGNI ARIELA , PARIS SIMONA , RUGGENENTI PIERO , ZOJA CARLA , ROSSI CHIARA , REMUZZI GIUSEPPE 
Published: May 2021

Abstract.
Heterogeneous abnormalities in multimeric structure and fragmentation of endothelial-derived von Willebrand factor (vWF) have been reported in hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). This study was conducted to establish whether different patterns of vWF abnormalities were associated with different clinical syndromes. Plasmatic levels of vWF antigen (vWF:Ag), vWF release from endothelial cells (EC) exposed to patient sera, and vWF multimeric pattern were studied during episodes and again in remission in three groups of patients with severe forms of HUS and TTP paradigmatic of the most common clinical patterns of disease presentation: (1) plasma-responsive; (2) plasma-resistant; and (3) frequently relapsing. Plasma vWF:Ag and serum-induced vWF release from EC were increased in the acute phase of either plasma-responsive and plasma-resistant HUS and TTP, but normalized at remission only in plasma-responsive cases. Both indices were persistently normal in the relapsing forms. Enhanced vWF fragmentation as defined by disappearance of high molecular weight and increase in low molecular weight forms was a consistent finding of the acute phases, and always normalized in remission in all three groups. Unusually large vWF multimers were found exclusively in plasma of relapsing forms of HUS and TTP both during and between relapses. Enhanced levels of vWF:Ag and serum capability to induce vWF release in vitro are markers of disease activity and may reflect systemic endothelial injury and consequent activation. Their presence discriminates acute single-episode cases from relapsing forms and, when failing to normalize with plasma therapy, predicts plasma resistance. Enhanced low molecular weight multimers that closely paralleled disease activity suggest a permissive role of fragmented vWF in the formation of microvascular thrombi. Finally, finding of unusually large multimers exclusively in relapsing forms of HUS and TTP even between relapses, when no other clinical signs of disease activity could be detected, suggests that they cannot be the only factor in microvascular thrombosis.
Acute and Chronic Renal Effects of Recombinant Human TGF-β2 in the Rat
Authors: KELLY FRANCIS J. , ANDERSON SHARON , THOMPSON MICHELE M. , OYAMA TERRY T. , KENNEFICK THOMAS M. , CORLESS CHRISTOPHER L. , ROMAN RICHARD J. , KURTZBERG LESLIE , PRATT BRUCE M. , LEDBETTER STEVEN R. 
Published: May 2021

Abstract.
The expression of transforming growth factor-β (TGF-β) correlates with the incidence of renal glomerular and interstitial injury, however, nothing is known of the effect of these proteins on renal hemodynamics. This study examines the renal hemodynamic and morphologic effects of recombinant human TGF-β2 in normal male Sprague Dawley rats. Acute infusion of TGF-β2 (1.2 μg/kg per min) induced no hemodynamic changes, except for a modest though significant fall in mean arterial pressure. Administering TGF-β2 at varying doses (20, 100, and 400 μg/kg) for 9 wk caused modest increases in systolic BP and proteinuria and minimal tubular interstitial fibrosis, however, renal hemodynamic end points were not significantly altered. TGF-β2 (800 μg/kg) was also administered to volume-depleted rats for 7 consecutive days. In contrast to the findings in volume-replete animals, administration of TGF-β2 to volume-depleted rats caused a marked reduction in GFR and medullary blood flow. Histologic fibrosis of the medullary vasa recta and cortical interstitium was seen, but glomeruli were unaffected. Thus, acute and short-term chronic TGF-β2 administration did not induce major renal changes in the volume-replete state, however, TGF-β2 combined with volume depletion caused medullary hypoperfusion and reduced GFR.
Prevalence, Predictors, and Consequences of Late Nephrology Referral at a Tertiary Care Center
Authors: ARORA PRADEEP , OBRADOR GREGORIO T. , RUTHAZER ROBIN , KAUSZ ANNAMARIA T. , MEYER KLEMENS B. , JENULESON CONSTANCE S. , PEREIRA BRIAN J. G. 
Published: May 2021

Abstract.
Despite improvements in dialysis care, mortality of patients with end-stage renal disease (ESRD) remains high. One factor that has thus far received little attention, but might contribute to morbidity and mortality, is the timing of referral to the nephrologist. This study examines the hypothesis that late referral of patients to the nephrologist might lead to suboptimal pre-ESRD care. Clinical and laboratory data were obtained from the patient records and electronic databases of New England Medical Center, its affiliated dialysis unit (Dialysis Clinics, Inc., Boston), and the office records of the outpatient nephrology clinic. Early (ER) and late (LR) referral were defined by the time of first nephrology encounter greater than or less than 4 mo, respectively, before initiation of dialysis. Multivariate models were built to explore factors associated with LR, and whether LR is associated with hypoalbuminemia or late initiation of dialysis. Of the 135 patients, 30 (22%) were referred late. There were no differences in age, gender, race, and cause of ESRD between ER and LR patients. However, there were significant differences in insurance coverage between these two groups. In the multivariate analysis, patients covered by health maintenance organizations were more likely to be referred late (odds ratio = 4.5) than patients covered by Medicare. Compared to ER, LR patients were more likely to have hypoalbuminemia (56% versus 80%), hematocrit <28% (33% versus 55%), and predicted GFR <5 ml/min per 1.73 m2 (17% versus 40%) at the start of dialysis, and less likely to have received erythropoietin (40% versus 17%) or have a functioning permanent vascular access for the first hemodialysis (40% versus 4%). It is concluded that late referral to the nephrologist is common in the United States and is associated with poor pre-ESRD care. Pre-ESRD care of patients treated by nephrologists was also less than ideal. The patient-, physician-, and system-related factors behind this observation are unclear. Meanwhile, pre-ESRD educational efforts need to target patients, generalists, and nephrologists.
Effect of Intravenous Saline, Albumin, or Hydroxyethylstarch on Blood Volume during Combined Ultrafiltration and Hemodialysis
Authors: VAN DER SANDE FRANK M. , KOOMAN JEROEN P. , BARENDREGT JOS N. M. , NIEMAN FRED H. M. , LEUNISSEN KAREL M. L. 
Published: May 2021

Abstract.
It is generally advocated to use saline or albumin infusions during symptomatic hypotension during dialysis. However, because of their side effects and/or costs, they are of limited use. Hydroxyethylstarch (HES), a synthetic colloid with a long-standing volume effect, is used in the management of hypovolemia. In this study, the efficacy of three fluids (isotonic saline [0.9%], albumin [20%], and HES [10%]) was assessed during three treatment sessions with combined ultrafiltration and hemodialysis, which differed in the type of fluid given intravenously. Changes in relative blood volume (BV), systolic BP (SBP), and vascular reactivity (venous tone [VT]) were compared. An intravenous infusion of 100 ml of fluid was given when the decrease in BV versus baseline was more than 10% as measured by a continuous optical reflection method. The ultrafiltration was continued. BV decreased significantly versus baseline independent of the intravenous fluid administration in all three treatment sessions. However, when we compared BV values at the end of the dialysis session with those at the time of infusion, BV continued to decrease significantly with saline (change in BV -4.56 ± 2.75%; P < 0.05) and albumin (change in BV - 2.13 ± 2.51%; P < 0.05), but not with HES (change in BV -0.15 ± 2.17%; NS). Between albumin and HES there were no significant differences in changes in BV (NS), whereas between HES and saline (P < 0.05) and between albumin and saline (P < 0.05) the differences in BV changes were significant. SBP remained unchanged within each session. Although SBP tended to decrease more with saline compared to albumin and HES, the difference was not significant. The higher decrease in BV and SBP with saline was counterbalanced by a significantly higher increase in VT, while VT remained unchanged in the other two sessions. It is concluded that HES is a promising fluid in preserving blood volume, comparable to albumin, but superior to saline.
Antihypertensive Medication and Renal Allograft Failure
Authors: SOROF JONATHAN M. , SULLIVAN E. KENNETH , TEJANI AMIR , PORTMAN RONALD J. 
Published: May 2021

Abstract.
Hypertension after renal transplantation occurs commonly and, in adults, is associated with decreased graft survival. The North American Pediatric Renal Transplant Cooperative Study database was analyzed to determine: (1) the percent use of antihypertensive (anti-HTN) medication based on donor type, race, age, and acute rejection status; and (2) whether use of anti-HTN medication is associated with higher rates of subsequent graft failure. Data regarding anti-HTN medication use was available in 5251 renal allografts (4821 patients) with >30 d graft function. Posttransplant follow-up data were collected at 30 d, 6 mo, 12 mo, and then annually for 5 yr. At each follow-up, patients were selected for further analysis if the graft was functioning at that visit and subsequent follow-up data were available. Overall, anti-HTN medication use was 79% on day 30 and 58% at 5 yr. At each follow-up, anti-HTN medication use was higher (P < 0.01) for cadaveric donor versus living related donor, blacks versus whites, age >12 versus <12 yr, and ≥1 versus 0 acute rejection episodes. Anti-HTN medication use at each annual follow-up was associated with significantly higher rates of subsequent graft failure. Multiple regression analysis controlling for all factors associated with increased use of anti-HTN medications revealed a relative risk of graft failure for use of anti-HTN medication of greater than 1.4 (P < 0.001). In recipients of cadaveric allografts, only acute rejection status predicted subsequent graft failure more strongly than use of anti-HTN medications. These data suggest that hypertension after renal transplantation in children, as evidenced by use of anti-HTN medications, is associated with increased rates of subsequent graft failure.
Apolipoproteins Prevent Glomerular Albumin Permeability Induced In Vitro by Serum from Patients with Focal Segmental Glomerulosclerosis
Authors: CANDIANO GIOVANNI , MUSANTE LUCA , CARRARO MICHELE , FACCINI LUIGI , CAMPANACCI LUCIANO , ZENNARO CRISTINA , ARTERO MARY , GINEVRI FABRIZIO , PERFUMO FRANCESCO , GUSMANO ROSANNA , GHIGGERI GIAN MARCO 
Published: May 2021

Abstract.
Glomerular albumin permeability alterations can be induced in vitro by serum from patients with end-stage renal disease caused by primary focal segmental glomerulosclerosis (FSGS). It was hypothesized that inhibitory substances may be present in normal serum, which may prevent the permeability alterations in isolated glomeruli, and the present study sought to isolate and characterize these factors. Albumin permeability was determined from the change in glomerular volume induced by applying oncotic gradients across the basement membrane of healthy isolated rat glomeruli preincubated with FSGS serum and normal serum fractionated using standard techniques. Fractions of normal serum with inhibitory activity obtained by a multistep chromatographic procedure underwent two-dimensional electrophoresis and staining. Approximately 50 protein spots were recovered, renatured, and tested for antipermeability activity. Five of these proteins demonstrated consistent inhibitory activity, and desorption ionization and mass spectrometry proved them to be components of high-density lipoprotein: apolipoproteins (apo) E2 and E4, high-molecular-weight J and L, and a 28-kD fragment of A-IV. Polyclonal antibodies to apo E or apo J added to the whole normal serum restored the permeability activity of the FSGS serum in the bioassay. Commercially available apo E and apo J also demonstrated antipermeability activity when added to FSGS serum. Cyanogen bromide digestion of apo A-IV produced fragments that inhibited the permeability activity of the FSGS serum, whereas the intact protein did not. Thus, components of high-density lipoprotein are capable of preventing glomerular albumin permeability induced by serum from patients with FSGS in an in vitro system. The specificity and mechanism of the inhibition remain to be determined; the alteration of normal inhibitory activity in vivo may be a component in the pathophysiology of FSGS.
Experimental 70% Hepatectomy Model: Apoptotic Index, Proliferative Index and Mitotic Index
Authors: İRKİN Latife Ceyda , ÖZTÜRK Şamil 
Published: May 2021

Liver regeneration is known to begin after experimentally induced liver resection. At first 24-48 hours, DNA synthesis reaches the maximum level after resection and significantly regeneration known to occur on the first 10 days. In this study, we was examined the regeneration of liver on the 1st and 14th days after the resection.
In experiment 21 Wistar albino male rats were used. The rats were randomly divided into three groups. All experimentally groups realized midline incision with laparotomy for resection of liver. Pedicles of the left lateral and median lobes of the liver were applied 70% hepatectomy by 4/0 silk binding. At the end of 1st and 14th days, liver tissue removed for light misroscobic analysis.
The tissue of all experimentally groups were showed some histopatological changes such as sinuzoidal dilatation, vacuolization in the hepatocytes. This histopatological findings were seem to increase at II. grup more than experimentally groups.
Mitotic index, apoptotic index and proliferation index of values at II. group was reached the maximum level. Other group (III) dramatically reduced the value of these index and were seem to reach near to values of the control group. Relative liver weight that determined each of experimentally groups were statistically significant differences compared to the control group.