bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estrogen Receptor 1 Inhibition of Wnt/β-Catenin Signaling Contributes to Sex Differences in Hepatocarcinogenesis
Authors: Bhat Mamatha , Pasini Elisa , Pastrello Chiara , Angeli Marc , Baciu Cristina , Abovsky Mark , Coffee Angella , Adeyi Oyedele , Kotlyar Max , Jurisica Igor 
Published: November 2021

BackgroundHepatocellular Carcinoma (HCC) is a sexually dimorphic cancer, with female sex being independently protective against HCC incidence and progression. The aim of our study was to understand the mechanism of estrogen receptor signaling in driving sex differences in hepatocarcinogenesis.MethodsWe integrated 1,268 HCC patient sample profiles from publicly available gene expression data to identify the most differentially expressed genes (DEGs). We mapped DEGs into a physical protein interaction network and performed network topology analysis to identify the most important proteins. Experimental validation was performed in vitro on HCC cell lines, in and in vivo, using HCC mouse model.ResultsWe showed that the most central protein, ESR1, is HCC prognostic, as increased ESR1 expression was protective for overall survival, with HR=0.45 (95%CI 0.32-0.64, p=4.4E-06), and was more pronounced in women. Transfection of HCC cell lines with ESR1 and exposure to estradiol affected expression of genes involved in the Wnt/β-catenin signaling pathway. ER-α (protein product of ESR1) agonist treatment in a mouse model of HCC resulted in significantly longer survival and decreased tumor burden (p&lt;0.0001), with inhibition of Wnt/β-Catenin signaling. In vitro experiments confirmed colocalization of β-catenin with ER-α, leading to inhibition of β-catenin-mediated transcription of target genes c-Myc and Cyclin D1.ConclusionCombined, the centrality of ESR1 and its inhibition of the Wnt/β-catenin signaling axis provide a biological rationale for protection against HCC incidence and progression in women.
Effect of Long-Term Exercise on Liver Lipid Metabolism in Chinese Patients With NAFLD: A Systematic Review and Meta-Analysis
Authors: Gao Ye , Lu Jiandong , Liu Xinhong , Liu Jingqi , Ma Qirui , Shi Yajun , Su Hao 
Published: November 2021

Purpose: Using meta-analysis to evaluate the effect of various long-term exercises (more than 4 weeks) on liver lipid metabolism of Chinese patients with non-alcoholic fatty liver disease (NAFLD) and provides more targeted exercise recommendations.Methods: Four databases consisting of PubMed, Web of Science, China Science and Technology Journal Database (VIP), China Knowledge Resource Integrated Database (CNKI) were searched up to May 2021. Randomized controlled trials (RCTs) were eligible, and the outcomes of body composition, lipid metabolism [including triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol (HDL-C)], and liver function [including alanine aminotransferase (ALT) and aspartate aminotransferase (AST)] were used to assess the effectiveness of long-term exercise on Chinese patients with NAFLD.Results: Eleven articles with a total of 13 data points (involving 1,006 participants) satisfied the inclusion criteria and were pooled in the meta-analysis. The findings demonstrated that long-term exercise decreased the level of TG [−0.50, 95%CI (−0.64, −0.36)], TC [−0.55, 95%CI (−0.92, −0.18)], LDL-C [−0.29, 95%CI (−0.43, −0.15)], ALT [−3.45, 95%CI (−6.78, −0.12)], AST [−6.91, 95%CI (−10.00, −3.81)], and body mass index (BMI) of patients who did exercise last more than 6 months [−1.55, 95%CI (−2.32, −0.79)] significantly. The effect on HDL-C was not obvious.Conclusion: Long-term exercise can improve the levels of TG, TC, LDL-C, ALT, and AST in Chinese patients with NAFLD significantly, and exercise last more than 6 months can decrease the BMI of Chinese patients with NAFLD.
Enhanced Recovery After Surgery in Patients With Hepatocellular Carcinoma Undergoing Laparoscopic Hepatectomy
Authors: Zhou Jiamin , He Xigan , Wang Miao , Zhao Yiming , Zhang Ning , Wang Longrong , Mao Anrong , Wang Lu 
Published: November 2021

Objective: To compare the effectiveness and safety of enhanced recovery after surgery (ERAS) in patients with hepatocellular carcinoma (HCC) undergoing laparoscopic hepatectomy.Methods: From September 2016 to June 2019, 282 patients were enrolled, and ERAS was implemented since March 2018. All indicators related to surgery, liver function, and postoperative outcomes were included in the analysis. Propensity score matching (PSM) identified 174 patients for further comparison.Results: After PSM, the clinicopathological baselines were well-matched. The group showed significantly less intraoperative blood loss (100.00 [100.00–200.00] vs. 200.00 [100.00–300.00] ml, P = 0.001), fewer days before abdominal drainage tube removal (4.00 [3.00–4.00] days vs. 4.00 [3.00–5.00] days, P = 0.023), shorter hospital stay after surgery (6.00 [5.00–6.00] days vs. 6.00 [6.00–7.00] days, P &lt; 0.001), and reduced postoperative morbidity (18.39 vs. 34.48%, P = 0.026). The proportion of patients with a pain score ≥ 4 was significantly lower in the ERAS group within the first 2 days after surgery (1.15 vs. 13.79% and 8.05 vs. 26.44%, P = 0.002 and P = 0.001, respectively). Pringle maneuver was performed more frequently in the ERAS group (70.11 vs. 18.39%, P &lt; 0.001), and a significantly higher postoperative alanine aminotransferase level was also observed (183.40 [122.85–253.70] vs. 136.20 [82.93–263.40] U/l, P = 0.026). The 2-year recurrence-free survival was similar between the two groups (72 vs. 71%, P = 0.946).Conclusions: ERAS programs are feasible and safe and do not influence mid-term recurrence in HCC patients undergoing laparoscopic hepatectomy.
Liver Bleeding Due to HELLP Syndrome Treated With Embolization and Liver Transplantation: A Case Report and Review of the Literature
Authors: Messina Valentina , Dondossola Daniele , Paleari Maria Chiara , Fornoni Gianluca , Tubiolo Daniela , Vergani Patrizia , Rona Roberto , Rossi Giorgio 
Published: November 2021

Background: Liver bleeding secondary to haemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome is uncommon, but a life-threatening peripartum condition that needs a prompt multidisciplinary approach.Case Presentation: In this study, we presented a case of 28-year-old pregnant woman, who was presented to the obstetrics department with signs of preeclampsia and foetal growth restriction. An emergency caesarean section was performed, and the patient developed a HELLP syndrome complicated by spontaneous liver rupture. After radiological and surgical procedures, liver failure became evident and liver transplantation was successfully performed. The patient and her daughter are now alive.Conclusions: Despite the rarity of this disease, liver complications due to HELLP syndrome must be properly diagnosed and treated given the gravity of the possible evolution in young women. After diagnosis, the patients must be treated in specialised centres with gynaecological, liver surgery, and transplant skills.
PENANGANAN STATUS KEPENDUDUKAN ETNIS ROHINGYA (STUDI KASUS KOTA MAKASSAR)
Authors: Asmar Abd. Rais 
Published: November 2021

AbstractThe handling of Rohingya ethnic refugees who entered the city of Makassar due to persecution in their home countries, Myanmar is very necessary because of the vulnerability experienced by Rohingya ethnic refugees, especially this is an international community agreement through the 1951 Convention on Refugees. This vulnerability can occur in children, women, and vulnerability to refugee status. Determination of refugee status is a full right of UNHCR because Indonesia has not ratified the 1951 Convention so that there is no government involvement in this matter both in terms of regulation and action. The fact is that Makassar City is one of the destinations for Rohingya ethnic refugees who want to improve their destiny. The government has issued Presidential Regulation No. 125 of 2016 concerning handling refugees but not yet adequate. As a result, they do not get residence status so they can enjoy educational, health, legal assistance and other needs because of administrative document problems. Therefore, national regulations are needed for them and the role of non-governmental institutions so that ethnic Rohingya refugees can enjoy the facilities available in Makassar City.Keywords: Rohingya Refugees, Population Status Abstrak Penanganan pengungsi etnis rohingya yang masuk ke Kota Makassar akibat persekusi di negara asalnya yaitu Myanmar sangat diperlukan karena kerentanan yang dialami oleh para pengungsi etnis rohingya apalagi ini merupakan kesepakatan masyarakat internasional melalui Konvensi 1951 tentang Pengungsi. Kerentanan tersebut dapat terjadi pada anak-anak, perempuan, maupun kerentanan status pengungsi. Penetapan status pengungsi menjadi hak penuh dari UNHCR karena Indonesia belum meratifikasi Konvensi 1951 sehingga tidak ada keterlibatan pemerintah dalam hal ini baik dalam hal regulasi maupun aksi. Faktanya Kota Makassar menjadi salah satu tujuan pengungsi etnis rohingya yang ingin memperbaiki nasib. Pemerintah telah mengeluarkan Perpres No. 125 Tahun 2016 tentang penanganan pengungsi tetapi belum memadai. Akibatnya mereka tidak mendapatkan status kependudukan sehingga dapat menikmati fasilitas pendidikan, kesehatan, bantuan hukum dan kebutuhan lainnya karena terbentur masalah dokumen adminstrasi. Oleh karena itu, dibutuhkan regulasi nasional yang memadai bagi mereka dan peran lembaga-lembaga non pemerintah agar pengungsi etnis rohingya dapat menikmati fasilitas yang ada di Kota Makassar.Kata Kunci: Pengungsi etnis rohingya, Status kependudukan
PERBUATAN MELAWAN HUKUM TERHADAP PEMALSUAN AKTA OTENTIK YANG DILAKUKAN NOTARIS
Authors: Wahyudin, Wahyudin, , Muliawan Jarot Widya 
Published: November 2021

AbstractThis research uses the Conceptual Approach Method and the Law Approach Method, on Normative Juridical Analysis by combining two data collection methods, namely Studying the Law and Examining library materials or secondary materials which are then analyzed using the Qualitative Analysis Method.The research results show that the notary can only (legally / in accordance with the rule of law) be a suspect if the notary intentionally keeps making a fake deed as requested by the tapper, even though he knows that the parties do not meet the legal requirements of the engagement. This shows that the notary does not strictly adhere to the Law on Notary Position (UUJN) and the Notary Professional Code of Ethics. Where it can lead to a notary public criminal act of forgery of authentic letters / deeds.The position of a Notary is held or its presence is desired by the laws and regulations with the intention of helping and serving people who need authentic written evidence regarding circumstances of events or legal actions of direct involvement by the parties facing them. However, in carrying out his profession, the police law apparatus is often summoned as a suspect in connection with the forgery of authentic deeds he has made. Thus, it is deemed necessary to know the Normative Juridical Analysis of Authentic Deed Falsification Conducted by Notaries. Keywords: Notary, Authentic Deed Falsification, Suspect. AbstrakPenelitian ini menggunakan Metode Pendekatan Konseptual dan Metode Pendekatan Undang-Undang, tentang Analisis Yuridis Normatif dengan cara menggabungkan dua metode pengumpulan data yaitu Menelaah Undang-Undang dan Meneliti bahan pustaka atau bahan sekunder yang Kemudian dianalisa dengan Metode Analisis Kualitatif.Hasil Penelitian menunjukkan bahwa notaris hanya dapat (legal/sesuai dengan aturan hukum) dijadikan sebagai tersangka apabila notaris tersebut dengan sengaja tetap membuat akta palsu sesuai yang diminta oleh penghadap, padahal ia mengetahui bahwa para pihak penghadap tersebut tidak memenuhi syarat-syarat sahnya perikatan. Hal ini menunjukkan bahwa notaris tersebut tidak berpegang teguh pada Undang-Undang Jabatan Notaris (UUJN) dan Kode Etik Profesi Notaris. Dimana dapat menjerumuskan notaris mengarah pada tindak pidana pemalsuan surat/akta otentik.Jabatan Notaris diadakan atau kehadirannya dikehendaki oleh Peraturan Perundang- undangan dengan maksud untuk membantu dan melayani masyarakat yang membutuhkan alat bukti tertulis yang bersifat otentik, mengenai keadaan peristiwa atau perbuatan hukum atas keterlibatan langsung oleh para pihak yang menghadap. Namun demikian Notaris dalam menjalankan profesinya tidak jarang dipanggil oleh pihak aparat hukum kepolisian sebagai tersangka Sehubungan dengan pemalsuan akta otentik yang dibuatnya. Sehingga, dipandang perlu untuk mengetahui Analisis Yuridis Normatif Terhadap Pemalsuan Akta Otentik Yang Dilakukan Oleh Notaris. Kata kunci: Notaris, Pemalsuan Akta Otentik, Tersangka.
ANALISIS MOTIVASI IBU HAMIL DALAM MENGIKUTI KELAS IBU HAMIL DI DAERAH PESISIR WILAYAH KERJA PUSKESMAS PANTAI AMAL KOTA TARAKAN
Authors: Retnowati Yuni , Ully Sulidah 
Published: November 2021

Pembelajaran kelas ibu hamil merupakan inovasi pelayanan antenatal yang terbukti dapat menurunkan AKI dan AKB. Tingkat partisipasi mengikuti kelas ibu hamil di Indonesia masih rendah; termasuk di Kota Tarakan. Rendahnya motivasi ibu hamil diduga menjadi faktor penyebab utama ketidakikutsertaan ibu hamil dalam kelas ibu hamil. Penelitian ini bertujuan untuk mengidentifikasi dan menganalis faktor motivasi ibu hamil di daerah pesisir dalam mengikuti kelas ibu hamil. Penelitian ini dilakukan di wilayah kerja Puskesmas Pantai Amal. Penelitian ini merupakan penelitian kuantitatif dengan pendekatan case control. Populasi penelitian ini adalah ibu hamil yang melakukan kunjungan di Puskesmas Pantai Amal sebanyak 118 orang. Besar sampel 64 orang yang terdiri dari 32 responden kelompok pengamatan dan 32 responden kelompok kontrol. Teknik sampling yang digunakan adalah puposive sampling. Hasil penelitian ini mengidentifikasi sebagian besar responden berusia 20-35 tahun dengan tingkat pendidikan menengah ke bawah; hampir seluruh responden tidak bekerja dan memiliki anak 1-2 orang. Motivasi mengikuti kelas ibu hamil umumnya rendah pada kelompok perlakuan, sedang pada kelompok kontrol memiliki motivasi tinggi. Analisis hubungan antara motivasi dan partisipasi kelas hamil menggunakan uji Mann-Whitney ditemukan p = 0,000 yang berarti terdapat hubungan yang bermakna antara motivasi dengan tingkat partisipasi dalam kelas ibu hamil. Tingkat pengetahuan yang rendah diduga menjadi faktor penyebab utama rendahnya motivasi mengikuti kelas ibu hamil. Direkomendasikan untuk menggiatkan program pendidikan kesehatan tentang kelas ibu hamil bagi ibu hamil diwilayah pesisir.Kata Kunci : Ibu Hamil, Kelas Ibu Hamil, Motivasi.
Hubungan antara self efficacy dengan kepatuhan minum obat hipoglikemik oral pada penderita dm tipe ii
Authors: Pramesti Theresia Anita , Saraswati Dewa Ayu Lilik , Wardhana Zainal Firdaus 
Published: November 2021

Keberhasilan pencegahan komplikasi Diabetes Melitus dapat dicapai salah satunya melalui kepatuhan dalam terapi farmakologi yaitu penggunaan Obat Hipoglikemik Oral. Keberhasilan suatu pengobatan pada pasien DM memerlukan kemampuan dan keyakinan yang tinggi pada diri sendiri atau yang disebut dengan Self efficacy. Tujuan penelitian ini adalah untuk mengetahui hubungan Self efficacy dengan kepatuhan minum obat hipoglikemik oral pada penderita diabetes melitus tipe II. Desain penelitian yang digunakan adalah deskriptif korelasional dengan rancangan cross sectional. Teknik sampling digunakan consecutive sampling dengan jumlah sampel sebanyak 60 orang penderita DM tipe II. Hasil penelitian didapatkan yaitu 25 orang (41,7%) memiliki Self efficacy dalam kategori tinggi dan 31 orang (51,7%) memiliki kepatuhan minum obat hipoglikemik oral dalam kategori tinggi. Hasil uji Rank Spearman dengan α = 0,05 didapatkan angka p value = 0,000 dan koefisien korelasi (r) = 0,936 yang berarti ada hubungan antara Self efficacy dengan kepatuhan minum obat hipoglikemik oral dengan kekuatan hubungan kuat dan berarah positif. Self efficacy akan berpengaruh terhadap kemampuan menyesuaikan diri, memahami dan mengenal masalah yang dihadapi dan memotivasi dirinya untuk suatu perubahan perilaku salah satunya kepatuhan berobat.
Effectiveness of an Otolaryngology Head and Neck Surgery Residents' Induction “Boot Camp” in Saudi Arabia
Authors: Alhashem Muataz H. , Alotaibi Naif H. , Alaadah Eulaf H. , Alnoury Ibrahim S. , Jebreel Alaeddin , Jabri Fouad , Hussain Fazal , Rajab M.H. 
Published: November 2021

ABSTRACT

Introduction
The otolaryngology (ORL) boot camp was designed to onboard ORL residents through a curriculum focusing on their needs as novice otolaryngologists. This boot camp provided systematic, specialty-wide training in core elements of knowledge, procedural skills, professionalism, supervision, and communications for residents entering ORL. The present study aimed to assess the effectiveness of an ORL resident induction “boot camp” in the Kingdom of Saudi Arabia.

Methods
This was a cross-sectional (multicenter) study encompassing data collection through an online voluntary questionnaire. Participants were new ORL residents in the Saudi residency training program.

Results
Fifty responses were returned, with a completion rate of 88%. Sixty-four percent of the respondents were male. Most of the respondents were aged from 26 to 27 years. Respondents were from different cities. Most participants agreed that the scientific value of the course was beneficial (agree, 40%; strongly agree, 44%) and they felt better prepared for their residency training after this boot camp (agree, 44%; strongly agree, 28%).

Conclusion
Boot camp in ORL is an additional important activity during the early years of training. It provides significant effects in terms of knowledge readiness at the beginning of specialty training. We believe that boot camp should include other dimensions of training, including surgical, communication, and judgmental skills, not only for the early years of training but also during the remaining period until training completion.
Actual Aspects of Surgical Treatment of Dupuytren's Disease (Literature Review)
Authors: Naumenko L.Yu. , Kondrashova I.A. 
Published: November 2021

Relevance. The variety of manifestations of Dupuytren's disease, caused by the degree of lesions of the palmar aponeurosis, the duration of the disease, the nature of professional activity, and concomitant pathology of patients, has led to the development of numerous surgical techniques with different levels of effectiveness in the acute and long-term periods. A wide discussion of the issues of Dupuytren's disease in the domestic and foreign periodicals, the analysis of treatment methods, complications and rehabilitation indicate the urgency of the problem and the expediency of further research.
Objective: a retrospective analysis of the leading literary sources devoted to the surgical treatment of Dupuytren's disease; the definition of modern approaches to surgical tactics and restoration of hand function.
Results. The analysis of literature sources showed the advantages of differentiated approaches to the surgical treatment of Dupuytren's disease, depending on the severity of the disease. With mild and moderate lesions, there is a significant increase in needle aponeurectomy. In severe forms, the segmental aponeurectomy technique is preferred over the total one. There is some discrepancy in carrying out surgical mobilization of the proximal interphalangeal joint and the need to achieve a functional position as a result of treatment. The tactics of surgical treatment and rehabilitation of Dupuytren's disease requires an individual approach, taking into account the age and severity of the disease, and tends to spread minimally invasive fasciotomy techniques.
QUALITY OF LIFE AS A FACTOR FOR INTEGRATION OF RESILIENCE RESEARCH OF ENERGY, SOCIO-ECOLOGICAL AND SOCIO-ECONOMIC SYSTEMS
Authors: Массель Людмила Васильевна , Пестерев Дмитрий Вячеславович 
Published: November 2021

Рассматривается понятие устойчивости в смысле «Resilience» и связанные с ним понятия энергетической и экологической безопасности. Предлагается рассматривать качество жизни как фактор интеграции исследований устойчивости энергетических, социо-экологических и социо-экономических систем. Вводятся критерии устойчивости энергетических, экологических и социальных систем. Когнитивное моделирование рассматривается как один из основных инструментов исследований устойчивости. Приводятся примеры когнитивного моделирования.
The concept of resilience and related concepts of energy and environmental safety are considered. It is proposed to use the quality of life as a integration factor of resilience research of energy, socio-ecological and socio-economic systems. Criteria for the resilience of energy, ecological and social systems are introduced. Cognitive modeling is seen as one of the main tools in resilience research. Examples of cognitive modeling are given.
APPLICATION OF A GEOINFORMATION SYSTEM FOR ASSESSING THE INFRASTRUCTURE ACCESSIBILITY OF REGIONS FROM THE PERSPECTIVE OF LAND USE PLANNING AND DEVELOPMENT
Authors: Расторгуев Иван Александрович , Щепетина Татьяна Дмитриевна , Баланин Андрей Леонидович 
Published: November 2021

Аналитическая ГИС-программа предназначена для целей многопараметрической оценки доступности транспортной и энергетической инфраструктуры, потенциала добычи полезных ископаемых, в т.ч. энергоресурсов, а также доступности альтернативных возобновляемых источников энергии в некотором определяемом географическими координатами месте, перспективном с точки зрения потребности развёртывания энергопроизводства, располагаемом в удаленных или труднодоступных районах России; для целей стратегического планирования развития регионов, освоения новых территорий, в т.ч. месторождений различных ресурсов. Практическое применение ГИС позволяет повысить эффективность процесса принимаемых стратегических решений.
The analytical GIS program is intended for the purposes of a multi-parameter assessment of transport and energy infrastructure availability, potential for mining, incl. energy resources, as well as availability of alternative renewable energy sources in a certain geographic location, promising from point of requirement for energy production deployment, located in remote or inaccessible regions of Russia; for the purposes of strategic planning of the development of regions, the development of new territories, incl. deposits of various resources. Practical application of GIS makes it possible to increase the efficiency of the strategic decision-making process.
FAST Discovery of a Long H i Accretion Stream toward M106
Authors: Zhu Ming , Yu Haiyang , Wang Jie , Xu Jin-Long , Du Wei , Yuan Lixia , Wang Jing , Jing Yingjie , Ai Mei , Jiang Peng 
Published: November 2021

Abstract
We report the discovery of a possible accretion stream toward a Milky Way–type galaxy M106 based on very deep H i imaging data with the Five-hundred-meter Aperture Spherical radio Telescope (FAST). The accretion stream extends for about 130 kpc in projection length and it is similar to the Magellanic stream in many respects. We provide unambiguous evidence based on the stream morphology, kinematics and local star formation activity to show that the H i gas is being accreted onto the disk of M106. Such a long continuous flow of gas provides a unique opportunity to probe the circumgalactic medium (CGM) and reveals how the gas stream traverses the hot halo and CGM, and eventually reaches the galaxy disk. The source of the stream appears to be from M106's satellite galaxy NGC 4288. We argue that the stream of gas could be due to the tidal interaction with NGC 4288, or with a high speed encounter near this system. Close to the position of UGC 7356 the stream bifurcates into two streams. The second stream may be gas tidally stripped from UGC 7356 or due to an interaction with UGC 7356. Our results show that high-sensitivity H i imaging is crucial in revealing low column density accretion features in nearby galaxies.