bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of organophosphate insecticide, sumithion on histopathology of common carp (Cyprinus carpio) in the natural pond condition
Authors: Shira M , Chowdhury P , Rahman MS , Haque SM , Shahjahan M 
Published: February 2021

Sumithion is an organophosphorus insecticide, which is widely used in aquaculture ponds for eradication of aquatic insect (mainly tiger bug) prior to release of larvae. This study was conducted to evaluate the effects of an organophosphorus pesticide, sumithion on histoarchitecture of liver and kidney in common carp (Cyprinus carpio) during the period from July to December 2016. It was carried out with four treatments, each with two replications. i.e., ponds with no sumithion (T0), with 0.025ppm sumithion (T1), 0.050 ppm sumithion (T2) and 0.100 ppm sumithion (T3). The water quality parameters, such as pH, dissolved oxygen, total alkalinity, free CO2, nitrate-nitrogen (NO3-N), phosphate-phosphorus (PO4-P) were not affected by sub lethal doses of sumithion but the values were fluctuated significantly in most of the cases between the ponds throughout the study period. In case of histoarchitecture of liver and kidney, normal structure of liver and kidney cells were observed in the controlled and treated fish. Through the histological analysis of liver, small vacuole, enlarge lumen space of hepatopancreas and disrupted hepatopancreas were found in T1. Disrupted hepatopancreas, increasement intracellular space, regeneration of hepatic cell and hemorrhage were observed in T2. Moreover, enlarge lumen space of hepatopancreas, degenerated hepatic cell, disrupted hepatopancreas were observed in T3. After the histological analysis of kidney, degenerated renal corpuscle, enlargement of blood vessel, disrupted hematopoetic cell were observed in T1. Ruptured collecting duct, large vacuole, enlarge intracellular space were observed in T2. Furthermore, enlarge bowman’s space, degenerated hematopoetic cell hemorrhage and ruptured distal tubule disrupted, enlarge intracellular space and necrosis were observed in T3. The present investigation sufficiently emphasizes that sumithion has adverse effects on the major organs like liver and kidney.
Int. J. Agril. Res. Innov. Tech. 10(2): 66-75, December 2020
Interactive effects of rice bran compost and chemical fertilizers on macronutrients, oil and protein content in sunflower (Helianthus annuus L.)
Authors: Alauddin M , Mohsin GM , Ali AHMZ , Rahman MK 
Published: February 2021

A field experiment was conducted at the research farm of Charfasson Govt. College, Bhola, Bangladesh in rabi season in 2015-2016 to evaluate the impact of conjunctive use of chemical fertilizers with rice bran on concentration, uptake and seed quality of sunflower cv. BARI-2 (Keroni-2). The experiment was laid out in the randomized complete block design (RCBD) having sixteen treatments with three replications. The size of the plots were 3 m x 2 m. Treatments were T1 Control (- RB and -NPK), T2: 2.5 t RB ha-1, T3: 5.0 t RB ha-1,T4: 7.5 t RB ha-1, T5: N40P30K50 kg ha-1,T6: N80P60K100 kg ha-1, T7: N120P90K150 kg ha-1, T8: 2.5 t RB ha-1 + N40P30K50 kg ha-1, T9: 2.5 t RB ha-1 + N80P60K100 kg ha-1, T10: 2.5 t RB ha-1 + N120P90K150 kg ha-1, T11: 5.0 t RB ha-1 + N40P30K50 kg ha-1, T12: 5.0 t RB ha-1 + N80P60K100 kg ha-1, T13: 5.0 t RB ha-1 + N120P90K150 kg ha-1, T14: 7.5 t RB ha-1 + N40P30K50 kg ha-1, T15: 7.5 t RB ha-1 + N80P60K100 kg ha-1, T16: 7.5 t RB ha-1 + N120P90K150 kg ha-1. Results showed that the concentration, uptake and quality of seeds (oil and protein) of the crop increased with increasing rate of the amendments significantly (P<0.05) over the control and the variation between the treatments were also significant irrespective of the sources of amendments in most of the cases. Generally, combination of the treatments showed better performance than their individual application. Maximum values of NPKS concentration (%) in different organs of sunflower were 1.22, 0.35, 1.90, 0.18 for stem; 1.17, 0.35, 2.41, 0.16 for root; 3.98, 0.43, 4.28, 0.24 for leaf, 1.04, 0.65, 3.00, 0.22 for petiole; 2.16, 0.58, 2.21, 0.26 for inflorescence and 5.24, 0.83, 1.60, 0.47 for seed measured in treatments 5.0 t RB ha-1 + N120P90K150 kg ha-1 and 7.5 t RB ha-1 + N120P90K150 kg ha-1 in most of the cases. However, their uptake pattern also followed the same trend as in concentration and the highest values were found in those treatments in most of the cases. Significantly (P<0.05%) the highest content of oil (51.1%) in seed was measured in the treatment 5.0 t RB ha-1 + N120P90K150 kg ha-1 and protein (33.9%) was found in the treatment 5.0 t RB ha-1 +N80P60K100 kg ha-1. Their lowest values were found in control for oil and in 2.5 t RB ha-1 for protein, which was lower than control treatment. The overall findings of this study indicated that rice bran in combination with chemical fertilizers could be applied to achieve better concentration and uptake in different organs, oil and protein content in seeds of sunflower.
Int. J. Agril. Res. Innov. Tech. 10(2): 91-99, December 2020
PENERAPAN FUZZY INFERENCE SYSTEM PEMILIHAN DESAIN INTERIOR
Authors: Jarti Nanda , Lestari Putri Weni 
Published: February 2021

Abstract: Interior design is currently growing. This can be seen from the various designs in each building. Each design has different characteristics and shapes. The problem that is often experienced by users is the lack of user knowledge in the field of interior design so that after the design is finished, the user is not satisfied with the results of the interior design. The main objective of this research is a decision making system in selecting interior designs according to user needs by paying attention to criteria such as design form, design size, material and quality. The method of selecting interior design using the Mamdani method. The mamdani method is very suitable in calculating the output value of each criterion value and the end result becomes the reference value in making a decision. The resulting system is in the form of design selection criteria according to user needs. Thus the results of this study get an Output value of 427,368 which is in the range with the value considered. Keywords: fuzzy inference system; interior design; mamdani method; software matlab. Abstrak: Desain Interior saat ini semakin berkembang, Hal ini bisa dilihat dari berbagai desain pada setiap bangunan. Setiap desain memiliki karakteristik dan bentuk yang berbeda beda. Permasalahan yang sering dialami pengguna yaitu kurangnya pengetahuan pengguna dibidang desain interior sehingga setelah desain selesai dikerjakan pengguna tidak Puas dengan hasil desain interior. Tujuan utama penelitian ini berupa Sistem pengambilan keputusan dalam pemilihan desain interior sesuai dengan kebutuhan pengguna dengan memperhatikan kriteria seperti Bentuk Desain, ukuran desain, bahan dan Kualitas. Metode pemilihan Desain interior menggunakan metode Mamdani. Metode mamdani sangat cocok dalam menghitung nilai output dari masing masing nilai kriteria dan hasil akhirnya menjadi nilai acuan dalam pengambilan sebuah Keputusan. Sistem yang dihasilkan berupa kriteria pemilihan desain sesuai kebutuhan pengguna. Dengan demikian Hasil penelitian ini mendapatkan nilai Output sebesar 427.368 yang berada pada range dengan nilai dipertimbangkan. Kata kunci: desain interior; fuzzy inference system; metode mamdani; software matlab.
PENGARUH PENGGUNAAN MEDIA PEMBELAJARAN INTERAKTIF BERBASIS ANDROID TERHADAP HASIL BELAJAR SISWA
Authors: Kartini Ketut Sepdyana , Putra I Nyoman Tri Anindia 
Published: February 2021

Penelitian ini bertujuan untuk mengetahui pengaruh implemetasi media pembelajaran interaktif berbasis android terhadap hasil belajar siswa pada materi tata nama IUPAC senyawa anorganik di SMAN 4 Denpasar. Metode penetilian yang digunakan adalah pretest-posttes group desain dengan sistem pengambilan sampel menggunakan cluster random sampling. Subjek penelitian terdiri dari 2 kelas yaitu kelas XI MIPA 3 sebagai kelas kontrol dan kelas XI MIPA 4 sebagai kelas eksperimen. Perlakukan pada dua kelas sampel dibedakan dengan implementasi media pembelajaran interaktif berbasis android pada kelas eksperimen sedangkan kelas kontrol tidak. Intsrumen yang digunakan adalah instrument tes soal uraian. Hasil penelitian menunjukkan bahwa uji t terhadap hasil belajar dengan diperoleh t hitung = 1,87 lebih besar dari t tabel = 1,67 di dukung dengan nilai N-gain dari kelas eksperimen sebesar 0,74 dibandingkan kelas kontrol. Selain itu hasil penelitian implementasi media pembelajaran interaktif berbasis android memiliki pengaruh sebesar 62,72% terhadap hasil belajar siswa.
Integrated Analysis of Key Genes and Pathways Involved in Nonalcoholic Steatohepatitis Improvement After Roux-en-Y Gastric Bypass Surgery
Authors: Chen Fu , Zhou Yong , Wu Zhiyuan , Li Yunze , Zhou Wenlong , Wang Yong 
Published: February 2021

BackgroundAs the incidence of nonalcoholic fatty liver disease (NAFLD) increases globally, nonalcoholic steatohepatitis (NASH) has become the second common cause of liver transplantation for liver diseases. Recent evidence shows that Roux-en-Y gastric bypass (RYGB) surgery obviously alleviates NASH. However, the mechanism underlying RYGB induced NASH improvement is still elusive.MethodsWe obtained datasets, including hepatic gene expression data and histologic NASH status, at baseline and 1 year after RYGB surgery. Differentially expressed genes (DEGs) were identified comparing gene expression before and after RYGB surgery in each dataset. Common DEGs were obtained between both datasets and further subjected to functional and pathway enrichment analysis. Protein–protein interaction (PPI) network was constructed, and key modules and hub genes were also identified.ResultsIn the present study, GSE106737 and GSE83452 datasets were included. One hundred thirty common DEGs (29 up-regulated and 101 down-regulated) were identified between GSE106737 and GSE83452 datasets. KEGG analysis showed that mineral absorption, IL-17 signaling pathway, osteoclast differentiation, and TNF signaling pathway were significantly enriched. Based on the PPI network,IGF1,JUN,FOS,LDLR,TYROBP,DUSP1,CXCR4,ATF3,CXCL2,EGR1,SAA1,CTSS, andPPARAwere identified as hub genes, and three functional modules were also extracted.ConclusionThis study identifies the global gene expression change in the liver of NASH patients before and after RYGB surgery in a bioinformatic method. Our findings will contribute to the understanding of molecular biological changes underlying NASH improvement after RYGB surgery.
Integrative Analysis of Transcriptome-Wide Association Study and mRNA Expression Profiles Identified Candidate Genes and Pathways Associated With Acute Myocardial Infarction
Authors: Chen Guanzhong , Liu Liwei , Li Huanqiang , Lun Zhubin , Mai Ziling , Lai Wenguang , Chen Enzhao , Zhou Chunyun , Yu Sijia , Yang Junqing , Chen Shiqun , Chen Jiyan , Liu Yong 
Published: February 2021

BackgroundAcute myocardial infarction (AMI), characterized by an event of myocardial necrosis, is a common cardiac emergency worldwide. However, the genetic mechanisms of AMI remain largely elusive.MethodsA genome-wide association study dataset of AMI was obtained from the CARDIoGRAMplusC4D project. A transcriptome-wide association study (TWAS) was conducted using the FUSION tool with gene expression references of the left ventricle and whole blood. Significant genes detected by TWAS were subjected to Gene Ontology (GO) enrichment analysis. Then the TWAS results of AMI were integrated with mRNA expression profiling to identify common genes and biological processes. Finally, the identified common genes were validated by RT-qPCR analysis.ResultsTWAS identified 1,050 genes for the left ventricle and 1,079 genes for whole blood. Upon comparison with the mRNA expression profile, 4 common genes were detected, including HP (PTWAS = 1.22 × 10–3, PGEO = 4.98 × 10–2); CAMP (PTWAS = 2.48 × 10–2, PGEO = 2.36 × 10–5); TNFAIP6 (PTWAS = 1.90 × 10–2, PGEO = 3.46 × 10–2); and ARG1 (PTWAS = 8.35 × 10–3, PGEO = 4.93 × 10–2). Functional enrichment analysis of the genes identified by TWAS detected multiple AMI-associated biological processes, including autophagy of mitochondrion (GO: 0000422) and mitochondrion disassembly (GO: 0061726).ConclusionThis integrative study of TWAS and mRNA expression profiling identified multiple candidate genes and biological processes for AMI. Our results may provide a fundamental clue for understanding the genetic mechanisms of AMI.
Epidemiological Variations in the Global Burden of Psoriasis, an Analysis With Trends From 1990 to 2017
Authors: Peng Chen , Xu Xin , Chen Wenjuan , Li Xingzi , Yi Xuemei , Ding Yangfeng , Yu Ning , Lu Jiajing 
Published: February 2021

Background: Although there have been many epidemiological studies, research focusing on psoriasis' health burden on a global scale is still lacking. Trends and variations in the global health burden of psoriasis are evaluated by time, age, gender, geographical location, and socioeconomic status, using disability-adjusted life years (DALYs) from the Global Burden of Disease Study.Methods: The health burden of psoriasis was evaluated by DALYs, which combined years lost to disability (a morbidity component) with years of life lost (a mortality component). The global and national DALYs number, crude DALYs rate, and age-standardized DALYs rate were obtained from the GBD 2017 study database. The corresponding human development index (HDI) was collected from the United Nations Development Programme.Results: From 1990 to 2017, the DALYs number and crude DALYs rate due to psoriasis increased by 73 and 22%, respectively. In comparison, the age-standardized DALYs rate showed a slight increase. Patients in the age range of 65–69 years bear a more significant psoriasis burden. Both males and females showed an increasing trend in burden caused by psoriasis over the past 27 years, with females bearing a more significant psoriasis burden than males. The health burden of psoriasis was substantially unequal in geography with a Gini coefficient of 0.27. The concentration indexes indicated a socioeconomic associated inequality in psoriasis burden with values of 0.22, accounting for 48.64% variance across countries (R2 = 0.4864, p &lt; 0.001). Between-nation inequality in the distribution of psoriasis burden continued to decline throughout the past 27 years. Gini coefficients of psoriasis burden decreased from 0.280 in 1990 to 0.265 in 2017. The concentration indexes indicated the same trend with 0.236 in the 1990s and 0.223 in 2017.Conclusions: Global health progress in psoriasis together with inequality in the past few decades. Although the inequality of psoriasis burden has shown some improvement during the past 27 years, disparities still exist in age, gender, geographical location, as well as socioeconomic status. The findings of this study highlight the global importance of psoriasis and is important in policy planning for psoriasis services on a global scale.
The Therapeutic Targets of Fingolimod (FTY720) Are Involved in Pathological Processes in the Frontal Cortex of Alzheimer's Disease Patients: A Network Pharmacology Study
Authors: Yin Pengqi , Xue Yang , Wang Tingting , Zhong Di , Li Guozhong 
Published: February 2021

Background: The sphingosine-1-phosphate receptor (S1PR) modulator fingolimod (FTY720), which is commonly used as an immunomodulator in multiple sclerosis treatment, has recently been found to reduce pathological changes in the brain tissue of Alzheimer's disease (AD) animal models, but this has yet to be verified in human brain tissue. In this study, network pharmacology methods were applied to determine the potential pharmacological mechanisms of fingolimod in the frontal cortex of AD patients.Methods: The pharmacological macromolecular targets of fingolimod and fingolimod phosphate were downloaded from SwissTarget and DrugBank. Systematic intersection analysis of the expression profiles of brain frontal cortex tissues (423 AD tissues and 266 control tissues) was performed to obtain AD-associated fingolimod targets (F-ADGs). Immune cell infiltration analysis and a primary mouse cortical culture RNA-seq drug screen database were used to identify immune-related F-ADGs and cortex-related F-ADGs. Then, the expression values of F-ADGs were correlated with the disease severity score (MMSE score) of AD patients to identify severity-related F-ADGs. We also analyzed miRNA expression microarray data in the frontal cortex of AD patients associated with disease severity to obtain severity-related F-ADG-miRNAs.Results: A total of 188 F-ADGs were detected in the frontal cortices of AD patients and were enriched in biological processes such as synaptic signaling, inflammatory response, and response to oxygen-containing compounds. Eleven immune-related F-ADGs (like FPR1, BLNK.) and 17 cortex-related F-ADGs (like ALDH1L1, DUSP1.) were detected. Other F-ADGs, such as S1PR1 and GABBR2, although not classified into the above two categories, were still predicted by bioinformatics methods to play an important role in the development of AD. Two F-ADGs (GNAQ and MMP14) and 28 miRNAs (like miR- 323a-3p, miR-181a-5p.) were found to be associated with AD severity (MMSE 0-27 group). Fifteen F-ADGs (like ALDH1L1, FPR1, and IL6.) and 46 miRNAs (like miR-212-5p, miR-93-5p.) were found to be associated with mild or moderate dementia AD patients' severity (MMSE11-22 subgroup).Conclusions: Fingolimod may affect the brain frontal cortex function of AD patients in many different ways, such as affecting immune cell infiltration, nerve cell, or glial cell function, and synaptic function. miRNAs may also be involved. ALDH1L1, FPR1, S1PR1, and GABBR2 may be core drug targets.
Primary Headache Disorder Among School Students in Kuwait
Authors: Shuaibi Sameera , AlAshqar Abdelrahman , Ahmed Samar Farouk , Alroughani Raed , AlThufairi Hawraa , Owayed Shaikhah , AlHamdan Fajer , Al-Hashel Jasem 
Published: February 2021

Background: Primary headaches are remarkably prevalent worldwide and are increasingly reported among children. However, the exact trend in this age group, particularly in the Gulf region, remains largely unknown.Aims and Objectives: To examine the prevalence of primary headache disorders among primary and middle school students in Kuwait.Methods: We conducted a cross-sectional study that included Kuwaiti primary and middle school children and adolescents of both genders in randomly selected schools located in two governorates in Kuwait in the 2018/2019 academic year. Prevalence and attributable burden of headaches, definite and probable migraines, definite and probable tension-type headaches, chronic headaches (≥15 days/month), and probable medication-overuse headaches were assessed using the Headache-Attributed Restriction, Disability, Social Handicap, and Impaired Participation (HARDSHIP) questionnaire for children and adolescents.Results: Of 1,485 questionnaires that were distributed, 1,089 students completed the questionnaire with a respondent rate of 73.4%. The study population consisted of 420 boys (38.56%) and 669 girls (61.43%) students with a mean age of 11.5 ± 2.11 years. The 1-year prevalence of primary headache disorders was 42.78%, with more middle schoolers reporting headaches than primary schoolers (50.37 vs. 30.48%; p &lt; 0.02). The mean age of students with primary headaches was 11.98 ± 2.03 years in both genders. When stratified according to diagnostic criteria, migraine headaches were the most frequently reported (20.75%), followed by tension type headaches (18.8%), chronic headaches (2.75%), and probable medication-overuse headaches (0.46%). Primary headaches were significantly higher in girls compared to boys among middle schoolers (66.46 vs. 38.49%; p &lt; 0.001); however, no significant difference between genders was noted among primary school students (33.12 vs. 22.33%; p &lt; 0.118).Conclusion: Primary headaches are remarkably common in Kuwaiti school students, with migraine headaches being the most frequently reported type. Age and female gender may play a role in the development of primary headaches. These findings necessitate the direction of health services and research efforts toward this age group and warrant the need for further epidemiological studies.
Clinical and MRI Differences Between Patients With Subacute Combined Degeneration of the Spinal Cord Related vs. Unrelated to Recreational Nitrous Oxide Use: A Retrospective Study
Authors: Gao Han , Li Weishuai , Ren Jing , Dong Xiaoyu , Ma Ying , Zheng Dongming 
Published: February 2021

Objective: To explore the clinical and imaging characteristics of subacute combined degeneration of the spinal cord (SCD) related to recreational nitrous oxide (N2O) use.Methods: Clinical and imaging data were retrospectively collected from patients with SCD related to recreational N2O use who were diagnosed and treated at Shengjing Hospital of China Medical University from January 2016 to June 2020. The clinical and imaging features of patients with recreational N2O-related SCD were compared with those of patients with N2O-unrelated SCD, who were diagnosed and treated during the same period of time.Results: The study enrolled 50 patients (male/female: 22/28, age: 21.4 ± 4.7 years) with N2O-related SCD and 48 patients (male/female: 27/21, age: 62.0 ± 11.4 years) with SCD unrelated to N2O use. The most common signs/symptoms of the patients in both groups were limb numbness and weakness and unsteady gait, but the incidence of limb weakness, unsteady gait, disorders of urination and defecation, anorexia, reduced deep sensation in lower limbs, ataxia, and positive Babinski sign were lower in the N2O-related SCD group than those in the N2O-unrelated SCD group (P &lt; 0.05). The functional disability rating score of patients in the N2O-related SCD group (median: 3, IQR: 2–5) was also significantly lower than the score in the N2O-unrelated SCD group (median: 5, IQR: 4–7) (P &lt; 0.05). The serum vitamin B12 level was significantly lower in the N2O-unrelated SCD group (median: 96 pg/mL, IQR: 50–170 pg/mL) than the level in the N2O-related SCD group (median: 218 pg/mL, IQR:121–350 pg/mL) (P &lt; 0.05), while both groups had similarly increased levels of homocysteine (P &gt; 0.05). Compared with the N2O-unrelated SCD patients, more patients with N2O-related SCD had abnormal spinal magnetic resonance imaging (MRI) scans (80.0 vs. 64.2%). The patients with N2O-related SCD also had wider spinal lesions on sagittal MRI (5.3 ± 0.8 mm vs. 4.2 ± 1.0 mm), fewer spinal segments with lesions (median: 5, IQR: 4–6 segments vs. median: 6, IQR: 5–7.5 segments), and a higher incidence of the inverted V sign on axial MRI (72.0 vs. 31.2%) (all P &lt; 0.05).Conclusion: The recreational use of N2O has become an important cause of SCD in young patients. Compared with the N2O-unrelated SCD patients, the N2O-related SCD patients had less severe clinical presentations, less obvious decrease in serum VB12 levels, and more obvious MRI changes.