bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Naoxueshu in acute spontaneous intracerebral hemorrhage: a multicenter observational study
Authors: Song Juexian , Nie Yuting , Qin Xinzuo , Wang Pingping , Lu Huiqiang , Gao Li 
Published: September 2021

AbstractObjectiveTo evaluate the efficacy and safety outcome and related risk factors of Naoxueshu in the treatment of acute SICH.MethodsTwo hundred twenty patients were enrolled in this study. Diagnosis of SICH was based on neuroimaging. All the patients received regular treatment and Naoxueshu oral liquid 10 ml 3 times a day for 14 consecutive days. Surgical intervention was conducted as needed. Efficacy and safety outcomes were evaluated.ResultsHematoma volume decreased significantly 7 days after Naoxueshu treatment (from 27.3 ± 20.0 to 15.1 ± 15.1 ml,P < 0.0001), and it decreased further in 14-day result (6.9 ± 10.4 ml,P < 0.0001). Patients’ neurological function was improved remarkably with NIHSS scores from baseline 13 points to 7-day 7 points (P < 0.0001) and 14-day 4 points (P < 0.0001). Cerebral edema was relieved only 14 days after Naoxueshu treatment (from 3 to 2 points,P < 0.0001). No clinically significant change was found in 7-day and 14-day safety results. Female sex was related independently to large 7-day hematoma volume and worse 7-day NIHSS score while it would not affect patients’ 14-day outcomes. Rare cause of SICH (B = 17.4,P = 0.009) alone was related to large 14-day hematoma volume. Worse baseline NIHSS score (B = 0.3,P = 0.003) and early use of Naoxueshu (B = 2.9,P = 0.005) were related to worse 7-day and14-day neurological function.ConclusionNaoxueshu oral liquid could relieve hematoma volume and cerebral edema safely; meanwhile, it could improve patients’ neurological function. Sex, cause of SICH, and time from onset to receive Naoxueshu should be taken into consideration in the treatment of SICH.
Lonely societies: low trust societies? Further explanations for national variations in loneliness among older Europeans
Authors: Rapolienė Gražina , Aartsen Marja 
Published: September 2021

AbstractCross-national studies in Europe reveal sharp regional differences in the prevalence of loneliness among older adults, with the highest prevalence of loneliness in Eastern European countries. In this study, we investigate an alternative explanation for differences in loneliness prevalence based on differences in trust. Many of the Eastern European countries were ruled by totalitarian regimes that undermined people’s trust in other people and in the system, potentially leading to higher loneliness prevalence. Data are derived from the sixth round of the European Social Survey conducted in 2012, based on 12,042 respondents, of which 4827 live in post-totalitarian countries and 7215 in other European countries and Israel. We estimate a path model with trust in people, trust in the system, and social engagement included as latent variables and one dichotomous outcome (lonely or not). We control for age, gender, health limitations, marital status, income adequacy, and education. The results reveal that loneliness is partly constructed by the social–cultural and historical–political characteristics of the countries in which people live. The higher prevalence of loneliness in the Eastern-European post-totalitarian countries can be linked to a low level of trust in other people through social disengagement. Considering the role of trust in the creation of individuals feelings of loneliness contributes to the understanding of country variations in loneliness and opens a new perspective in loneliness research and the development of policies aimed at reducing loneliness.
Completeness in Information Systems Ontologies
Authors: Tambassi Timothy 
Published: September 2021

AbstractIn the domain of information systems ontologies, the notion of completeness refers to ontological contents by demanding that they be exhaustive with respect to the domain that the ontology aims to represent. The purpose of this paper is to analyze such a notion, by distinguishing different varieties of completeness and by questioning its consistency with the open-world assumption, which formally assumes the incompleteness of conceptualizations on information systems ontologies.
Plenty of Room for Multilocation
Authors: Smid Jeroen 
Published: September 2021

AbstractClassical mereology is a particularly strong theory about the part–whole relation. Not only does it ensure that any collection of entities composes a whole, or ‘fusion’, it also states that this object is unique: no two entities have the same parts. Recently, Claudio Calosi (dialectica 68(1):121–139, 2014) has argued that this extensional aspect makes classical mereology incompatible with multilocated entities. Calosi’s argument is arguably the most precise one from a whole battery of arguments to the effect that some mereological principle is at odds with multilocation. Still, I show that Calosi’s arguments fail and that classical mereology is a safe space for multilocation. Moreover, I argue that the question of extensionality is orthogonal to the question of multilocation.
Integrated Treatment Programmes for Mothers with Substance Use Problems: A Systematic Review and Meta-analysis of Interventions to Prevent Out-of-home Child Placements
Authors: Neo Samantha H. F. , Norton Sam , Kavallari Despoina , Canfield Martha 
Published: September 2021

AbstractApproximately half of mothers receiving substance use treatment are involved with childcare proceedings. This review aims to determine whether integrated treatment programmes for mothers with substance use problems are effective in preventing out-of-home placement (temporally/permanent) and influencing other maternal factors such as patterns of substance use, treatment completion and parenting behaviours. Six trials were identified—two randomised controlled trials and four non-randomised controlled studies. The pooled sample of participants was 1717. The results showed that mothers who participated in integrated treatment programmes were significantly less likely to have the children removed from their care (Odds Ratio (OR) = 0.40, 95% CI = 0.27, 0.61), more likely to complete substance use treatment (OR = 3.01, 95% CI = 1.79, 5.06), and more likely to reduce their alcohol consumption (Standardised Mean Difference (SMD) = −0.40, 95% Cl = −0.78, −0.01) and drug use (SMD = −0.30, 95% CI = −0.53, −0.07). However, non-significant reductions were observed for parent–child conflict (SMD = −0.35, 95% CI = −0.72, 0.03) and child abuse risk (SMD = −0.03, 95% CI = −0.36, 0.31). While the findings from this review suggest that mothers involved in integrated treatment programmes could potentially be less likely to experience out-of-home child placements and more likely to improve substance use treatment outcomes, little evidence exists for the effectiveness of these interventions. Further research, particularly high-quality RCTs, is required to demonstrate and persuade health and public policy on the far-reaching value of the integrated approaches.
Thoracoscopic surgical atrial fibrillation ablation in patients with an extremely enlarged left atrium
Authors: Neefs Jolien , Wesselink Robin , van den Berg Nicoline W. E. , de Jong Jonas S. S. G. , Piersma Femke R. , van Boven WimJan P. , Driessen Antoine H. G. , de Groot Joris R. 
Published: September 2021

Abstract

Purpose
Efficacy of pulmonary vein isolation (PVI) for atrial fibrillation (AF) decreases as left atrial (LA) volume increases. However, surgical AF ablation with unknown efficacy is being performed in patients with a giant LA (GLA). We determined efficacy of thoracoscopic AF ablation in patients with compared to without a GLA.

Methods
Patients underwent thoracoscopic PVI with additional left atrial ablations lines (in persistent AF) and were prospectively followed up. GLA was defined as LA volume index (LAVI) ≥ 50 ml/m2. Follow-up was performed with ECGs and 24-h Holters every 3 months. After a 3-month blanking period, all antiarrhythmic drugs were discontinued. The primary outcome was freedom of any atrial tachyarrhythmia ≥ 30 s during 2 years of follow-up.

Results
At baseline, 68 (15.4%) patients had a GLA (LAVI: 56.7 [52.4–62.8] ml/m2), while 374 (84.6%) had a smaller LA (LAVI: 34.8 [29.2–41.3] ml/m2). GLA patients were older (61.9 ± 6.9 vs 59.4 ± 8.8 years, p = 0.02), more often diagnosed with persistent AF (76.5% vs 58.6%, p = 0.008). Sex was equally distributed (with approximately 25% females). GLA patients had more recurrences compared to non-GLA patients at 2-year follow-up (42.6% vs 57.2%, log rank p = 0.02). Freedom of AF was 69.0% in non-GLA paroxysmal AF patients compared to 43.8–49.3% in a combined group of GLA and/or persistent AF patients(log rank p < 0.001). Furthermore, freedom was 62.4% in non-GLA male patients, compared to 43.8–47.4 in a combined group of GLA and/or female sex(log rank p = 0.02).

Conclusion
Thoracoscopic AF ablation is an effective therapy in a substantial part of GLA patients. Thoracoscopic AF ablation may serve as a last resort treatment option in these patients.
On Representations of Intended Structures in Foundational Theories
Authors: Barton Neil , Müller Moritz , Prunescu Mihai 
Published: September 2021

AbstractOften philosophers, logicians, and mathematicians employ a notion of intended structure when talking about a branch of mathematics. In addition, we know that there are foundational mathematical theories that can find representatives for the objects of informal mathematics. In this paper, we examine how faithfully foundational theories can represent intended structures, and show that this question is closely linked to the decidability of the theory of the intended structure. We argue that this sheds light on the trade-off between expressive power and meta-theoretic properties when comparing first-order and second-order logic.
Circuits with a mem-element: invariant manifolds control via pulse programmed sources
Authors: Di Marco Mauro , Innocenti Giacomo , Tesi Alberto , Forti Mauro 
Published: September 2021

AbstractThe paper considers the problem of controlling multistability in a general class of circuits composed of a linear time-invariant two-terminal (one port) element, containing linear R, L, C components and ideal operational amplifiers, coupled with one of the mem-elements (memory elements) introduced by Prof. L.O. Chua, i.e., memristors, memcapacitors, and meminductors. First, explicit expressions of the invariant manifolds of the circuit are directly given in terms of the state variables of the two-terminal element and the mem-element. Then, the problem of steering the circuit dynamics from an initial invariant manifold to a final one, and hence to potentially switch among different attractors of the circuit, is addressed by designing pulse shaped control inputs. The control inputs ensure that the transition between the initial and final manifolds is accomplished within a given finite time interval. Moreover, it is shown how the designed control inputs can be implemented by introducing independent voltage and current sources in the two-terminal element. Notably, it turns out that it is always possible to solve the considered control problem by using a unique independent source. Several examples are provided to illustrate how the proposed approach can be applied to different circuits with mem-elements and to highlight the influence of the features of the designed sources on the behavior of the controlled dynamics.
Happiness and depression in psoriasis: a cross-sectional study in Germany
Authors: Schuster Barbara , Peifer Corinna , Ziehfreund Stefanie , Tizek Linda , Biedermann Tilo , Zink Alexander , Schielein Maximilian C. 
Published: September 2021

Abstract
Purpose
Prior research on the psychological consequences of skin diseases has focused on assessing mental comorbidities. The aim of this study was to investigate subjective well-being in a large sample of individuals affected by psoriasis, a chronic inflammatory skin disease, and to explore the associations with depression and disease-related parameters such as disease severity.

Methods
A cross-sectional online survey was conducted from March to June 2019. The link to the questionnaire was shared on websites and Facebook pages of psoriasis patient organizations and campaigns. Participants filled in validated scales measuring subjective well-being—operationalized as positive affect (PA), negative affect (NA) and satisfaction with life (SWL); and depression.

Results
The data of 722 participants were analyzed. Exploratory factor analysis supported the differentiation of PA, NA, SWL, and depression as four different constructs. The respondents reported lower levels of PA than healthy individuals and judged themselves to be less happy and were less satisfied with their lives than the general population (except age group 65 + years). 40.3% of respondents were screened positive for depression. More severe psoriasis was associated with lower affective well-being and a higher risk for depression.

Conclusion
The results of this study empirically supported the differentiation of subjective well-being and depression as different constructs in individuals with psoriasis, and underline the large mental burden of the disease which goes beyond a higher risk for depression. Measures of well-being should thus be incorporated in both research and clinical practice in patients with psoriasis in order to achieve a more comprehensive picture of the mental burden of this disease.
Marine Microplastics in Polar Region—a Spitsbergen Case Study
Authors: Dąbrowska Agnieszka 
Published: September 2021

AbstractThe aim of this short paper is to report the presence of primary and secondary microplastics in Svalbard and surrounding waters. The sampling and monitoring were done during the AREX 2017 polar expedition and included the Spitsbergen (Longyearbyen, Pyramiden) and western fjords, in particular Isfjorden, Kongsfjorden. Moreover, the unique scientific trawls were carried out in Raudefjorden at the very north coast of Spitsbergen. Finally, the plastic tide effects were confirmed at the Prins Karl Forland Island.
The efficacy of repetitions-in-reserve vs. traditional percentage-based resistance training: a 4-week pre-season randomized intervention in elite rugby league players
Authors: Sinclair Jonathan , Edmundson Christopher James , Bentley Ian 
Published: September 2021

Abstract
Purpose
This two-experiment study aimed to examine (1) the accuracy and reliability of repetitions-in-reserve and (2) using a randomized trial, the efficacy of repetition-in-reserve compared to traditional percentage-based training during a 4-week pre-season strength training block in elite rugby league players.

Methods
In experiment 1, participants performed deadlift, bench press and weighted pull up exercises for 3, 6, and 9 repetitions to failure using self-selected loads. This was undertaken on two occasions, separated by 8-weeks. In experiment 2, participants were randomly separated into either repetitions-in-reserve or percentage-based training groups. They completed a 4-week pre-season training block with training prescribed based on the group to which they were assigned. Measures of body mass and 3 repetition max strength in the aforementioned exercises were measured pre and post intervention.

Results
Experiment 1 showed that repetitions-in-reserve exhibited generally acceptable levels of accuracy and moderate-good levels of reliability. However, the deadlift when the required number of repetitions was 6 and 9 and the bench press when number of repetitions was 9 were not associated with acceptable levels of accuracy and reliability, respectively. Experiment 2 showed that there were no differences between repetitions-in-reserve or percentage-based training group for the strength outcomes, although there were significant increases in body mass in the percentage-based group (pre = 85.6 ± 10.6 kg, post = 86.4 ± 10.8 kg).

Conclusion
Repetitions-in-reserve is generally associated with acceptable levels of accuracy and moderate-good levels of reliability, although there were some exceptions for the deadlift in relation to accuracy and bench press for reliability. Experiment 2 shows that although there were no differences between groups for the strength-based outcomes, significant increases in body mass in the percentage-based group may make this approach a more effective approach to prepare players for the rigors of the rugby league season.
Anti-trypanosomal screening of Salvadoran flora
Authors: Castillo Ulises G. , Komatsu Ayato , Martínez Morena L. , Menjívar Jenny , Núñez Marvin J. , Uekusa Yoshinori , Narukawa Yuji , Kiuchi Fumiyuki , Nakajima-Shimada Junko 
Published: September 2021

AbstractChagas disease is caused by the protozoan parasite Trypanosoma cruzi, and in Central America, it is considered one of the four most infectious diseases. This study aimed to screen the anti-trypanosomal activity of plant species from Salvadoran flora. Plants were selected through literature search for plants ethnobotanically used for antiparasitic and Chagas disease symptomatology, and reported in Museo de Historia Natural de El Salvador (MUHNES) database. T. cruzi was incubated for 72 h with 2 different concentrations of methanolic extracts of 38 species, among which four species, Piper jacquemontianum, Piper lacunosum, Trichilia havanensis, and Peperomia pseudopereskiifolia, showed the activity (≤ 52.0% viability) at 100 µg/mL. Separation of the methanolic extract of aerial parts from Piper jacquemontianum afforded a new flavanone (4) and four known compounds, 2,2-dimethyl-6-carboxymethoxychroman-4-one (1), 2,2-dimethyl-6-carboxychroman-4-one (2), cardamomin (3), and pinocembrin (5), among which cardamomin exhibited the highest anti-trypanosomal activity (IC50 = 66 µM). Detailed analyses of the spectral data revealed that the new compound 4, named as jaqueflavanone A, was a derivative of pinocembrin having a prenylated benzoate moiety at the 8-position of the A ring.

Graphic abstract
Improving K-12 Teachers’ Acceptance of Open Educational Resources by Open Educational Practices: A Mixed Methods Inquiry
Authors: Tang Hengtao , Lin Yu-Ju , Qian Yingxiao 
Published: September 2021

AbstractTeachers in K-12 settings increasingly demand instructional materials beyond textbooks to follow the upward momentum of personalized instruction. Especially during the outbreak of COVID-19, K-12 teachers are forced to quickly adapt to online teaching and thus have more difficulties of delivering personalized instruction in a relatively resource-restraint situation. Open educational resources (OER), allowing teachers to retain, reuse, revise, remix, and redistribute high-quality educational resources at no costs, can be a viable option for teachers. However, the acceptance of OER in K-12 education still remains low. Effective strategies are needed to reinforce teacher intention to adopt OER. This research showcased a two-phase sequential explanatory mixed method inquiry to investigate whether engaging K-12 teachers in open educational practices (OEP)—such as renewable assignments—increased their acceptance of OER. The quantitative phase, referring to the technology acceptance model (TAM), examined the change in factors influencing teachers’ acceptance of OER. The qualitative phase was followed up to provide supplementary perspectives of the quantitative findings. By integrating complementary findings, this research found that OEP increased teachers’ perceived ease of and self-efficacy towards using OER. Although teachers’ intention of implementing OER is not significantly improved, qualitative findings offered additional insights into the benefits of OEP in promoting OER usage and the recommended directions for future effort. Practical implications on improving teachers’ acceptance of OER in K-12 curriculum are discussed at the end.
Emerging Economy Inward and Outward Foreign Direct Investment: A Bibliometric and Thematic Content Analysis
Authors: da Silva-Oliveira Keilla Dayane , de Miranda Kubo Edson Keyso , Morley Michael J. , Cândido Rodrigo Médici 
Published: September 2021

AbstractResearch examining emerging economy inward and outward foreign direct investment (FDI) flows is on a significant upward trajectory. In this bibliometric analysis covering 806 articles published between 1994 and 2019, we map key aspects of its contours. Our analysis proceeds in two sequential phases involving a performance analysis, followed by a thematic analysis. Our performance analysis unveils fundamental elements of the structure of the knowledge base. Our subsequent thematic analysis identifies three focal topics arising from identifiable shared qualities characterizing this literature. Firstly, we distinguish scholarship focused on inward FDI into emerging economies formed by two particular classes, namely ‘innovative FDI’ and ‘capital flows’. Our second theme covers outward FDI from these emerging economies and also comprises two specific classes referring to the ‘institutional environment’ and the ‘theoretical framework deployed’. Our final theme relates to an integrated body of knowledge explicating aspects of the location choice decision. Building on this analysis, we isolate a number of opportunities for future research.
Iterated nonexpansive mappings in Hilbert spaces
Authors: Piatek Bozena 
Published: September 2021

AbstractIn [T. Dominguez Benavides and E. Llorens-Fuster, Iterated nonexpansive mappings, J. Fixed Point Theory Appl. 20 (2018), no. 3, Paper No. 104, 18 pp.], the authors raised the question about the existence of a fixed point free continuous INEA mapping T defined on a closed convex and bounded subset (or on a weakly compact convex subset) of a Banach space with normal structure. Our main goal is to give the affirmative answer to this problem in the very special case of a Hilbert space.
A novel in vitro assay to study chondrocyte-to-osteoblast transdifferentiation
Authors: Tschaffon Miriam E. A. , Reber Stefan O. , Schoppa Astrid , Nandi Sayantan , Cirstea Ion C. , Aszodi Attila , Ignatius Anita , Haffner-Luntzer Melanie 
Published: September 2021

Abstract
Purpose
Endochondral ossification, which involves transdifferentiation of chondrocytes into osteoblasts, is an important process involved in the development and postnatal growth of most vertebrate bones as well as in bone fracture healing. To study the basic molecular mechanisms of this process, a robust and easy-to-use in vitro model is desirable. Therefore, we aimed to develop a standardized in vitro assay for the transdifferentiation of chondrogenic cells towards the osteogenic lineage.

Methods
Murine chondrogenic ATDC5 cells were differentiated into the chondrogenic lineage for seven days and subsequently differentiated towards the osteogenic direction. Gene expression analysis of pluripotency, as well as chondrogenic and osteogenic markers, cell–matrix staining, and immunofluorescent staining, were performed to assess the differentiation. In addition, the effects of Wnt3a and lipopolysaccharides (LPS) on the transdifferentiation were tested by their addition to the osteogenic differentiation medium.

Results
Following osteogenic differentiation, chondrogenically pe-differentiated cells displayed the expression of pluripotency and osteogenic marker genes as well as alkaline phosphatase activity and a mineralized matrix. Co-expression of Col2a1 and Col1a1 after one day of osteogenic differentiation indicated that osteogenic cells had differentiated from chondrogenic cells. Wnt3a increased and LPS decreased transdifferentiation towards the osteogenic lineage.

Conclusion
We successfully established a rapid, standardized in vitro assay for the transdifferentiation of chondrogenic cells into osteogenic cells, which is suitable for testing the effects of different compounds on this cellular process.