bluuebunny/crossref_metadata_2025_split huggingface dataset:
Racial and Ethnic Inequities in the Receipt of Medications to Treat Opioid Use Disorder Among Pregnant People: A Meta-analysis
Authors: Gerdts Grace , Sale Katherine , Raynor Phyllis , Schiff Davida M. , Terplan Mishka , Bush Elsie , Nidey Nichole 
Published: February 2025

Objectives:
The aim of this meta-analysis is to examine inequities in the receipt of medications for opioid use disorder (MOUD) by race and ethnicity among pregnant people.

Methods:
PubMed and Embase were searched for studies examining the relationship between race and ethnicity and the receipt of MOUD during pregnancy. Studies were included if they were observational in nature and reported sufficient data to ascertain effect measures. Random-effects meta-analyses were conducted to estimate the pooled odds ratios (OR) with 95% CIs.

Results:
Fourteen studies were included with data on 157,208 individuals. Receipt of MOUD among Black (pooled OR: 0.35, 95% CI: 0.23, 0.55) and Hispanic (pooled OR: 0.60, 95% CI: 0.40, 0.89) pregnant people was significantly lower compared to their White counterparts. Among all other racial and ethnic categories, receipt of MOUD was nonsignificantly lower compared to White pregnant people (pooled OR: 0.79, 95% CI: 0.56, 1.12). Ten studies utilized self-reported race and ethnicity, and 3 studies reported data on well-defined racial and ethnic categories outside of White, Black, and Hispanic.

Conclusions:
There is strong evidence of racial and ethnic inequities in the receipt of MOUD during pregnancy. We hypothesize these inequities to be caused by structural and interpersonal racism impacting the quality of care for pregnant people with opioid use disorder. Increased use of self-identified race and ethnicity alongside improved reporting of racial and ethnic categories beyond Black, White, and Hispanic is needed in future research to better understand and measure constructs related to racism.
Pediatricians’ Attitudes Toward and Use of Terminology About Mothers With Opioid Use Disorder
Authors: Ratner Jessica A. , Chaiyachati Barbara H. , Demharter Neera Shah , Gannon Meghan , Hossain Jobayer , Larkin Olivia , McAllister Jennifer M. , Peera Fateh , Schiff Davida M. , Sibinga Erica M.S. , Rohde Jessica F. , Goyal Neera K. 
Published: February 2025

Objectives:
Stigmatizing experiences for mothers with opioid use disorder (OUD) may impede health care engagement. We sought to characterize attitudes and terminology use among pediatric primary care clinicians as a potential target for improvement.

Methods:
We conducted a cross-sectional survey of 1004 clinicians at 28 clinics affiliated with 7 US residency programs (April to June 2022). Survey questions focused on trust, blame, and support for mothers with OUD were adapted from prior studies of self-reported attitudes, and terminology was categorized as preferred versus nonpreferred based on national recommendations. Frequencies were tabulated, and a 2-stage process of factor analysis and k-means clustering was used to group respondents by attitudinal responses. Multivariable logistic regression evaluated the association between participant characteristics and attitudinal groups.

Results:
Of 272 respondents (response rate 27.1%), most were female, non-Hispanic White residents; the distribution of clinical roles was similar among nonrespondents. Use of nonpreferred terminology was infrequent, although over 69% reported usual or occasional use of “substance abuse.” Analyses supported clustering respondents across 3 main constructs of trust, blame, and support. About 27% were categorized as having a low level of blame, and about 38% had a high level of trust. Adjusting for covariates, high trust was associated with confidence in training to provide care for opioid-exposed children (adjusted odds ratio [AOR] 1.84, P=0.04), and low blame was associated with education on OUD stigma (AOR 3.43, P=0.001).

Conclusions:
Pediatrician attitudes reflecting mistrust and blame toward mothers with OUD are not uncommon but may be addressed through training and education.
Menstrual Pain and Substance Use in Women Receiving Inpatient Treatment for Substance Use Disorders
Authors: Sugarman Dawn E. , Haidamus Mia A. , McHugh R. Kathryn , Griffin Margaret L. , Weiss Roger D. , Payne Laura A. 
Published: February 2025

Objectives:
Pain is a risk factor for substance use and can negatively affect outcomes of substance use disorder (SUD) treatment. Menstrual pain is common among menstruating women yet has received little attention in the substance use literature. This study aimed to characterize menstrual pain and explore the association between menstrual pain and substance use in women receiving SUD treatment.

Methods:
Participants in SUD inpatient treatment were recruited for a cross-sectional self-report survey study. The current analyses focused on participants who reported a menstrual cycle in the past 6 months (N=56) and completed a questionnaire to assess menstrual cycle characteristics, menstrual pain severity, and menstrual pain interference. Substance use (eg, alcohol, cocaine) and misuse of medications to relieve menstrual pain (ie, used without a prescription or in any way other than prescribed) was also assessed.

Results:
Half of the participants (n=28) reported using substances for menstrual pain; the most commonly used substances were cannabis, alcohol, and nicotine/tobacco. Menstrual pain severity was associated with substance use to manage menstrual pain (B=0.34, SEB=0.11, P<0.01); higher pain interference was associated with higher odds of using substances to manage menstrual pain (B=0.55, SEB=0.16, P<0.001).

Conclusions:
These results indicate that menstrual pain is highly prevalent in this population and may be a risk factor for substance use among women in SUD treatment. Conducting menstrual history assessments with patients seeking SUD treatment might be clinically helpful. It may also be helpful for clinicians to closely monitor the impact of menstrual pain on substance use and treatment outcomes.
US Youth Exposed to Parental Substance Use Disorder in the Home: A Comparison of DSM-IV and DSM-5 Criteria
Authors: Schepis Ty S. , Veliz Philip T. , West Brady T. , McCabe Vita V. , Hulsey Eric , Kcomt Luisa , McCabe Sean Esteban 
Published: February 2025

Purpose:
Youth (children and adolescents under 18 yrs) exposed to parental substance use disorder (SUD) are at high risk for poor outcomes that include substance use, psychopathology, and child welfare involvement. With the changing SUD criteria from DSM-IV to DSM-5, revised estimates of youth exposed to parental SUD in the home are needed to provide more recent estimates and investigate whether the change from DSM-IV to DSM-5 may change estimated SUD exposure.

Methods:
Nationally representative data from the 2020 National Survey on Drug Use and Health were used. Weighted counts of youth exposed to parental nonnicotine SUD in the home were estimated using both DSM-IV and DSM-5 criteria, which were assessed for every substance used by the parent in the past year; further analyses estimated counts by parental race/ethnicity, sex, household income, urbanicity, and substance leading to the SUD diagnosis.

Results:
Parents with DSM-IV SUD had an estimated 9,341,336 youth in their households, versus an estimated 16,937,783 using DSM-5 criteria (81.3% greater). Larger increases were observed in Asian (262.9%) or multiracial (161.9%) parents versus parents of other racial/ethnic groups and in parents with cannabis use disorder (246.4%), with smaller increases observed in parents with alcohol use disorder (71.2%)

Discussion:
The change from DSM-IV to DSM-5 criteria resulted in a large increase in youth exposed to parental SUD. The health needs of these youth will require large-scale planning to limit poor outcomes in the roughly 17 million exposed youth; family-based interventions may help limit harms to all members of the family.
Peri-operative blood loss after administration of pre-operative intravenous tranexamic acid versus administration of intra-operative intra-articular tranexamic acid in primary total knee arthroplasty surgery: a prospective comparative cohort study
Authors: Abdelmoneim Mohamed , Eliesh Ihab Gamal , El-Desouky Ihab Ibrahim , Farahat Ahmed 
Published: February 2025

Background:
Tranexamic acid (TXA) has regularly been found to decrease the need for transfusions after major orthopedic surgery. The study aimed for comparing intra-operative blood loss, Hemoglobin (Hb), platelets drop, redivac blood loss, patients’ Knee Society Score (KSS), and safety of TXA in patients undergoing primary TKA using either topical or intravenous (IV) TXA.

Methods:
Study was conducted between February 2023 to December 2023. The patients were divided into T Group using topical TXA and IV group used IV TXA. Inclusion Criteria were skeletally mature patients, indicated for primary TKA. Exclusion Criteria were allergy and/or hypersensitivity to TXA, a documented history of thromboembolic disease, pre-operative renal or hepatic dysfunction, revision TKA cases, and previous osteosynthesis around the knee.

Results:
Mean follow-up period was 3.9 weeks. Drain output in the T group was comparable with IV group (511 compared with 512 mL respectively; P<0.001). The topical and IV groups did not differ significantly with respect to the rate of thrombotic events nor infection development. There was no statistically significant variation between both groups regarding post-operative Knee society score.

Conclusion:
TXA has a significant role in decreasing blood loss perioperatively thus decreasing need for blood transfusion and hospital stay with no significant difference between the use of IV and topical methods.
Methodology of a Social Network Survey in Primary Care Practices With Medical Home Attributes
Authors: Dixon Justinna , Turi Eleanor , Pollifrone Madeline , Featherston Kyle , Liu Jianfang , Martsolf Grant , Poghosyan Lusine 
Published: February 2025

Objective: To provide an overview of the methods of a social network survey used to collect data in primary care practices on team structures, compositions, and social networks (eg, support, communication). Methods: A cross-sectional sociometric social network survey in 23 primary care practices with medical home attributes in New York and Pennsylvania was conducted. All primary care providers (ie, physicians, nurse practitioners, physician assistants), clinical staff (eg, registered nurses, social workers, and nutritionists, etc), and administrative staff (eg, practice managers, office assistants, etc) in each practice were eligible to participate in the online survey. All practice members received an online survey asking them to identify who they work with during a typical week. Data were collected about the characteristics of respondent’s relationships with each identified team member, perceived team effectiveness, and respondent-level job satisfaction, intent to leave, burnout, and demographics. We calculated the overall response rate and compared it among practices with different practice sizes and respondent roles using chi-square tests and independent samples t-tests. Results: The survey yielded an average response rate of 51.8%, with a range between 21.8% and 82.3% across the practices. Three hundred ninety-four primary care providers, 222 clinical staff, and 173 administrative staff responded to the survey. Respondents (n = 792) were more likely to be from smaller practices and be administrative or clinical staff rather than providers. Conclusion: This social network survey of primary care providers and staff used innovative approaches to collect data on team structures beyond traditional methods. Despite declining response rates in healthcare provider surveys, our survey reached high response rates in several practices. Future studies should find ways to engage primary care providers and staff in survey research.
Potential drug targets for systemic lupus erythematosus identified through Mendelian randomization analysis
Authors: Fan Shiwen , Wang Kaixin , Wang Shuai , Chen Xiangdong 
Published: February 2025

So far, there is no clear pathogenesis and no cure for systemic lupus erythematosus (SLE). The therapeutic benefits of existing drug therapies are far from ideal. The proteome is a major source of therapeutic targets. Therefore, new drug targets for SLE need to be discovered. Based on the STROBE-Mendelian randomization (MR) checklist, we performed MR to explore potential drug targets for SLE, using genome-wide association study summary statistics of plasma and cerebrospinal fluid (CSF) and further replicated in the external validation. Bidirectional MR, reverse causality testing by Steiger filtering, Bayesian co-localization were used. In addition, protein–protein interaction networks (PPI) were performed to reveal potential associations between proteins and current SLE drugs. At false discovery rate (FDR) significance (P

FDR
< .05), MR analysis revealed 8 proteins. Five proteins decreased the SLE risks, whereas the other 3 proteins increased the SLE risks. None of the 8 proteins had reverse causality except sICAM-1. Bayesian co-localization suggested that 5 proteins shared the same variant with SLE. PPI network suggested that intercellular adhesion molecular 1 (ICAM-1), Fc-gamma-RIIb (FCG2B) and N-terminal pro-B-type natriuretic peptide (N-terminal pro-BNP) interacted with targets of current SLE medications. Our integrative analysis revealed that SLE risk is causally associated with ICAM-1, FCG2B, and N-terminal pro-BNP. These 3 proteins have the potential to become drug targets of SLE, especially for ICAM-1 and FCG2B. More further studies are also warranted to support this finding.
Efficacy of prone positioning in awake ventilation for COVID-19: Umbrella review
Authors: Guo Dan-yang , Zhang Qin , Wang Li , Pu Zai-chun , Jia Ping 
Published: February 2025

Background:
Awake-prone positioning was widely used in COVID-19, combined with high-flow nasal oxygen therapy or noninvasive ventilation, effectively reducing intubation, and the effect on mortality is controversial. We aim to reevaluate the efficacy of awake-prone positioning in COVID-19 and summarize the protocol for awake-prone positioning.

Methods:
We gathered data on the treatment of COVID-19 using awake-prone positioning from Web of Science, Cochrane Library, Embase, PubMed, and CNKI. All the included studies were published between 2019 and 2023. Two researchers used the Assessment of Multiple Systematic Reviews tool to assess the methodological quality of the literature. The evidence was assessed using the Grading of Recommendations Assessment and Evaluation system.

Results:
Thirteen articles were included. The quality assessment using AMSTAR2 revealed that 3 articles were high quality, and 4 were moderate quality. The evidence quality assessment of 41 primary outcomes by the Grading of Recommendations Assessment, Development and Evaluation indicates that 9 indicators were of moderate quality, 21 were of low quality, and 6 were of very low quality.

Conclusions:
The review demonstrates high methodological quality, but the evidence quality of its outcome indicators is low. Awake-prone position has been shown to decrease intubation and improve oxygenation in COVID-19 patients. It is recommended to consult the latest quality assessment standards to develop more rigorous experimental protocols, improve research quality, and facilitate the translation of research findings.
Anti-dipeptidyl-peptidase-like protein-6 encephalitis with late-onset gastric cancer: A case report and 2-year follow-up
Authors: Wu Guolu , Shi Yanhui , Sun Jialan , Wu Feifei , Jiang Mei , Li Qiang 
Published: February 2025

Rationale:
Anti-dipeptidyl-peptidase-like-protein 6 (DPPX) encephalitis is a rare form of autoimmune encephalitis, with no more than 80 cases reported to date. Cases of anti-DPPX encephalitis comorbid malignancy are exceedingly rare. Limited cases and diverse clinical presentations bring difficulties in the understanding of this disease, including the etiology, diagnosis, treatment, and prognosis. Herein, we report a case of insidious-onset anti-DPPX encephalitis in a patient with a prior history of Epstein-Barr Virus (EBV) meningitis diagnosed with gastric cancer after 2 years of follow-up.

Patient concerns:
A 72-year-old emaciated male presented with recurrent seizures over the last 20 years, personality changes over 10 years, and memory loss lasting 2 years.

Diagnoses:
The patient was diagnosed with epilepsy, psychiatric symptoms (agitation and irritability), and mild cognitive impairment. Anti-DPPX encephalitis and prior EBV infection were ultimately diagnosed based on the combination of his symptoms and positive DPPX antibody in serum (titer 1:10) and positive EBV-IgG antibody in cerebrospinal fluid.

Interventions:
The patient received a course of intravenous methylprednisolone and oral sodium valproate to treat the seizures.

Outcomes:
After 10 days of treatment, no seizures reoccurred, although the psychiatric symptoms persisted, and his serum antibody against DPPX was still positive (titer 1:10). Unfortunately, the family members asked for the patient to be discharged automatically and refused oral steroids after discharge. Through regular telephone follow-ups for 2 years after discharge, we learned that the patient did not experience any similar convulsions but still showed irritability when administered perphenazine. Unfortunately, the patient had gastric cancer with multiple metastases and was receiving palliative care.

Lessons:
This report illustrates a rare case of EBV meningitis in childhood, resulting in a long-standing, stable course of anti-DPPX encephalitis, and subsequent gastric cancer. This case broadens the atypical presentation spectrum of anti-DPPX encephalitis and emphasizes the need for screening for malignant tumors, including lymphoma, nasopharyngeal carcinoma, and gastric cancer, particularly in patients with latent EBV infection.
Comparison of Diagnostic Accuracies of Commonly Used Trial of Void Parameters
Authors: Shinnick Julia K. , Raker Christina A. , Geller Elizabeth J. , Rardin Charles R. , Cooper Anne C. 
Published: February 2025

(Abstracted from Urogynecology (Phila) 2024;30:888–895)
Standard care after pelvic surgical procedures often includes assessing for postoperative urinary retention, which is evaluated using postoperative trials of void (TOV). Accuracy of TOV findings is needed to limit both excess catheterization and health care utilization.
Fetal Fraction of Cell-Free DNA in Noninvasive Prenatal Testing and Adverse Pregnancy Outcomes: A Nationwide Retrospective Cohort Study of 56,110 Pregnant Women
Authors: Becking Ellis C. , Scheffer Peter G. , Henrichs Jens , Bax Caroline J. , Crombag Neeltje M.T.H. , Weiss Marjan M. , Macville Merryn V.E. , Van Opstal Diane , Boon Elles M.J. , Sistermans Erik A. , Henneman Lidewij , Schuit Ewoud , Bekker Mireille N. 
Published: February 2025

(Abstracted from Am J Obstet Gynecol 2024;231:244.e1–244.e18)
Noninvasive prenatal testing (NIPT) for Down, Edwards, and Patau syndromes is widely available. Its accuracy depends on a sufficient amount of fetal cell-free DNA (cfDNA) in maternal plasma.
MiR-340-5p affects the proliferation and transfer of gastric cancer cells by targeting lncRNA HCG11 and NRF2 expression
Authors: Su Rina , Luan Wei , Zhang Kai , Liu Shuai , Zhang Xiaoqing , Gao Yanwei 
Published: February 2025

Abstract

Objective
The aim of the study was to investigate the expression and biological role of nuclear factor erythroid–related factor 2 (NRF2) in gastric cancer cells.

Methods
Western blotting (WB) and reverse transcription-polymerase chain reaction (RT-PCR) were used to detect the expression of NRF2 in the tumor tissues of patients with gastric cancer and MKN45 cells. NRF2 was transfected into MKN45 gastric cancer cells, and apoptosis was detected using flow cytometry. The 3-(4,5-dimethylthiazole-2-yl)-2.5-dipheny-tetrazolium bromide (MTT) assay was performed to detect cell proliferation. Transwell and scratch experiments were performed to detect cell invasion and migration rates. WB blotting was performed to detect Bcl-2, COX-2, PEG2, Bax, and Cyt-C protein expression. RT-PCR was used to detect Bcl-2, COX-2, PEG2, Bax, Cyt-C, miR-340-5p, lncRNA HCG11, and NRF2 mRNA expression.

Results
NRF2 expression increased in gastric cancer tissues and in the MKN45 gastric cancer cell model. Compared with the blank group, the shNRF2 knockdown group showed a significant increase in the MKN45 gastric cancer cell apoptosis rate (p < 0.05) and a significant decrease in invasion and migration rates (p < 0.05). WB and RT-PCR showed that, in the shNRF2 knockdown group, Bcl-2 protein and mRNA, miR-340-5p, and lncRNA HCG11 expression was significantly increased, whereas COX-2, PEG2, Bax, and Cyt-C protein and mRNA expression was significantly reduced (p < 0.05). In the NRF2 overexpression group, Bcl-2 protein and mRNA expression was significantly reduced, whereas COX-2, PEG2, Bax, and Cyt-C protein and mRNA expression was significantly increased (p < 0.05). The opposite was observed for the NRF2 overexpression group. When miR-340-5p mimics were transfected into MKN45 gastric cancer cells, NRF2 and HCG11 expression significantly reduced (p < 0.05). When the miR-340-5p inhibitor was transfected into MKN45 gastric cancer cells, NRF2 and HCG11 expression significantly increased (p < 0.05).

Conclusions
The invasion, migration, abnormal proliferation, and apoptosis of MKN45 gastric cancer cells are closely related to an imbalance in NRF2 expression, suggesting that MiR-340-5p may target and regulate the lncRNA HCG11, thereby inhibiting NRF2 expression.
Scintigraphic Improvement of Primary Intestinal Lymphangiectasia in a Patient Treated With Alpelisib for a PIK3CA-Related Overgrowth Spectrum
Authors: Dubois Julien , Vauchot Fabien 
Published: February 2025

Abstract
A 33-year-old man with primary intestinal lymphangiectasia (Waldmann disease) associated with PIK3CA-related overgrowth spectrum was explored using 99mTc serum albumin scintigraphy before and during treatment by alpelisib, a specific PIK3CA inhibitor. Before treatment, scintigraphic images evidenced a focal uptake on the right colonic angle 4 hours postinjection (p.i.), diffusing to the transverse and left colon 24 hours p.i., compatible with a diffuse colonic exudation. Significant scintigraphic improvement was observed with a disappearing of the right colonic angle uptake 4 hours p.i. and later images 14 months after alpelisib introduction.