bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Fish Oil Supplementation on Cardiometabolic Risk Factors in Overweight or Obese Children and Adolescents: A Meta-Analysis of Randomized Controlled Trials
Authors: Wu Shaojing , Zhu Chunhong , Wang Zhen , Wang Shumei , Yuan Pengfei , Song Tao , Hou Xiaoli , Lei Zhixian 
Published: April 2021

Background: Influences of fish oil supplementation on body weight and other cardiometabolic factors in overweight or obese children and adolescents remain not fully understood. We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the role of fish oil for these children.Methods: Relevant studies were obtained by search of PubMed, Embase, and Cochrane's Library databases. A random-effect model, which incorporates the potential heterogeneity of the included studies, was used to pool the results.Results: Twelve RCTs including 1,028 overweight or obese children and adolescents were included. Compared to control, fish oil supplementation significantly reduced body mass index [BMI, mean difference (MD): −0.96 kg/m2, 95% confidence interval (CI): −1.69 to −0.23, P = 0.01] but did not significantly reduce body weight or waist circumference (P = 0.68 and 0.76). Moreover, fish oil supplementation significantly reduced serum triglyceride (MD: −0.24 mmol/L, 95% CI: −0.40 to −0.08, P = 0.004) but did not significantly affect serum total cholesterol and high-density or low-density lipoprotein cholesterol (P = 0.83, 0.42, and 0.31, respectively). Additionally, fish oil supplementation significantly lowered systolic blood pressure (SBP, MD: −2.46 mmHg, 95% CI: −4.93 to −0.01, P = 0.04) but did not significantly change diastolic blood pressure (P = 0.22). Supplementation with fish oil did not significantly affect fasting plasma glucose (P = 0.33).Conclusions: In overweight or obese children and adolescents, supplementation with fish oil could reduce BMI, decrease serum triglyceride, and lower SBP, while serum cholesterol and fasting glucose may not be significantly affected.
Current Status and Trends in Peptide Receptor Radionuclide Therapy in the Past 20 Years (2000–2019): A Bibliometric Study
Authors: Lu Xiaojing , Lu Cuncun , Yang Yongjie , Shi Xiangfen , Wang Haibo , Yang Nan , Yang Kehu , Zhang Xiaojian 
Published: April 2021

Background: Peptide receptor radionuclide therapy (PRRT) is an emerging therapeutic option for the treatment of neuroendocrine tumors (NETs), and the number of publications in this field has been increasing in recent years. The aim of the present study was to present the research status and summarize the key topics through bibliometric analysis of published PRRT literature.Methods: A literature search for PRRT research from 2000 to 2019 was conducted using the Science Citation Index Expanded of Web of Science Core Collection (limited to SCIE) on August 4, 2020. The VOSviewer, R-bibliometrix, and CiteSpace software were used to conduct the bibliometric analysis.Results: From 2000 to 2019, a total of 681 publications (523 articles and 158 reviews) were retrieved. Annual publication outputs grew from three to 111 records. Germany had the largest number of publications, making the largest contribution to the field (n = 151, 22.17%). Active cooperation between countries/regions was observed. Kwekkeboom from the Erasmus Medical Center is perhaps a key researcher in the field of PRRT. The European Journal of Nuclear Medicine and Molecular Imaging and Journal of Nuclear Medicine ranked first for productive (n = 84, 12.33%) and co-cited (n = 3,438) journals, respectively. Important topics mainly included matters related to the efficacy of PRRT (e.g., 90Y-dotatoc and 177Lu-dotatate), the long-term adverse effects of PRRT (e.g., hematologic and renal toxicities), standardization of NETs and PRRT in practice, the development of medical imaging techniques, and the individual dose optimization of PRRT.Conclusion: Using bibliometric analysis, we gained deep insight into the global status and trends of studies investigating PRRT for the first time. The PRRT field is undergoing a period of rapid development, and our study provides a valuable reference for clinical researchers and practitioners.
Medication-Related Problems in Liver Transplant Recipients in the Outpatient Setting: A Dutch Cohort Study
Authors: Mulder Midas B. , Borgsteede Sander D. , Darwish Murad Sarwa , Landman Catelijne S. , Metselaar Herold J. , Hunfeld Nicole G.M. 
Published: April 2021

Background: After liver transplantation (LTx), adherence to immunosuppressive medication and avoidance of contra-indicated drugs is essential for long-term survival. This study aimed to investigate the prevalence, types and severity of medication-related problems (MRPs) and interventions initiated by a clinical pharmacist (CP) in a cohort of LTx recipients in the outpatient setting.Method: This study was a retrospective, observational study in LTx recipients that visited the outpatient clinic for an annual check-up. A 20-minutes consultation with a CP consisted of medication reconciliation and consultation about medication, adherence, and adverse drug reactions (ADRs). Discrepancies between actual and intended drug use, and MRPs were identified and the severity of MRPs was assessed. Potential interventions were discussed with the patient and the treating physician and evaluated after one year.Results: The CP counseled 64 LTx recipients and found 96 discrepancies in 37 patients. Most discrepancies (60.4%, n = 58) concerned missing medications.In total, 98 MRPs were identified in 53 patients (median 2; range 1-5 per patient), with a total of 113 interventions. Most frequent MRPs were: ADRs (22.4%, n = 22), nonadherence (19.3%, n = 19), unnecessary drugs (16.3%, n = 16) and undertreatment (12.2%, n = 12). Interventions most frequently proposed included optimization of dosage regimen (21.2%, n = 24), individualized recommendation regarding compliance (16.8%, n = 19) and drug discontinuation (12.4%, n = 14). After one year, 15 of the 19 patients (79%) experienced no longer compliance issues and 27 of the 29 patients (93%) used no drugs with indication issues anymore.Conclusion: The CP in an outpatient monitoring program for LTx recipients can signal relevant discrepancies and MRPs. This leads to interventions that are accepted by both the patients and the physicians, with a positive effect after one year.
Informing About the Nocebo Effect Affects Patients’ Need for Information About Antidepressants—An Experimental Online Study
Authors: Nestoriuc Yvonne , Pan Yiqi , Kinitz Timm , Weik Ella , Shedden-Mora Meike C. 
Published: April 2021

Relevance: Understanding patients’ informational needs and adapting drug-related information are the prerequisites for a contextualized informed consent. Current information practices might rather harm by inducing nocebo effects.Objective: To investigate whether informing about the nocebo effect using a short information sheet affects patients’ need for information about antidepressants.Methods: A total of 97 patients taking recently prescribed antidepressants (≤4 months intake) were recruited over the internet and randomized to receiving either a one-page written information about the nocebo effect or a control text about the history of antidepressants. After experimental manipulation, informational needs about the side effects and mechanisms of antidepressants were assessed with 3 and 7 items on categorical and 5-point Likert scales. Group differences in informational needs were calculated with Chi-square tests and ANOVAs.Results: Patients received antidepressants for depression (84.5%) and/or anxiety disorders (42.3%). Three participants (6.0%) of the nocebo group reported previous knowledge of the nocebo effect. After the experimental manipulation, participants in the nocebo group reported a reduced desire for receiving full side effect information [X(4,97)2 = 12.714, Cramer’s V = 0.362, p = 0.013] and agreed more frequently to the usefulness of withholding information about possible side effects [X(4,97)2 = 14.878, Cramer’s V = 0.392, p = 0.005]. Furthermore, they desired more information about the mechanisms of antidepressants (F = 6.373, p = 0.013, partial η2 = 0.063) and, specifically, non-pharmacological mechanisms, such as the role of positive expectations (F = 16.857, p &lt; 0.001, partial η2 = 0.151).Conclusions: Learning about the nocebo effect can alter patients’ informational needs toward desiring less information about the potential side effects of antidepressants and more information about general mechanisms, such as expectations. The beneficial effects of including nocebo information into contextualized informed consent should be studied clinically concerning more functional information-seeking behavior, which may ultimately lead to improved treatment outcomes, such as better adherence and reduced side effect burden.
Personality to Prescription Drug Misuse in Adolescents: Testing Affect Regulation, Psychological Dysregulation, and Deviance Proneness Pathways
Authors: Stewart Sherry H. , Chinneck Annie , Thompson Kara , Afzali Mohammad H. , Nogueira-Arjona Raquel , Mahu Ioan T. , Conrod Patricia J. 
Published: April 2021

Background: Fifteen to 25-year-olds are the age group most likely to misuse prescription drugs. Few studies have tested theory-driven models of adolescent risk for prescription drug misuse. Moreover, rarely are distinct pathways to different forms of prescription drug misuse considered.Methods: We tested mediational paths from personality to mental health symptoms to prescription drug misuse, informed by etiological models of addiction. We specified pathways from particular personality traits to unique forms of prescription drug misuse via specific mental health symptoms. We used semi-longitudinal data collected across two waves of the Co-Venture Trial. Our sample included students from 31 Canadian high schools tested in Grade 9 (n = 3,024) and again in Grade 10 (n = 2,869; 95% retention). Personality (hopelessness, anxiety sensitivity, impulsivity, sensation seeking) was assessed in Grade 9. Mental health symptoms (depression, anxiety, ADHD, conduct disorder) and prescription drug misuse (opioids, sedatives/tranquilizers, stimulants) were assessed at both time points.Results: Consistent with the negative affect regulation model, hopelessness was specifically associated with opioid misuse via depressive symptoms, and anxiety sensitivity was specifically associated with sedative/tranquilizer misuse via anxiety symptoms. Consistent with positive affect regulation, sensation seeking was directly associated with stimulant misuse. Consistent with the psychological dysregulation model, impulsivity was associated with stimulant misuse via ADHD symptoms. And consistent with the deviance proneness model, impulsivity was also associated with unconstrained (i.e., all three forms of) prescription drug misuse via conduct disorder symptoms.Conclusions: Screening for adolescents high in hopelessness, anxiety sensitivity, sensation seeking, or impulsivity and providing them with personality-matched cognitive-behavioral interventions may be helpful in preventing or mitigating prescription drug misuse. Our results point to the specific mental health symptoms that are important to target in each of these personality-matched interventions.
Keanekaragaman dan Pemanfaatan Tanaman Obat pada Pekarangan di Dumoga Utara, Kabupaten Bolaang Mongondow, Sulawesi Utara
Authors: Lestari Dewi , Koneri Roni , Maabuat Pience Veralyn 
Published: April 2021

(Article History: Received January 12, 2021; Revised March 8, 2021; Accepted April 7, 2021) ABSTRAKTanaman obat merupakan tanaman yang memiliki komponen aktif dan diyakini oleh masyarakat dapat menyembuhkan penyakit. Penelitian ini bertujuan untuk menganalisis keanekaragaman dan pemanfaatan tanaman obat pada pekarangan di Dumoga Utara, Kabupaten Bolaang Mongondow, Sulawesi Utara. Metode pengambilan sampel menggunakan purposive sampling. Pemilihan responden dilakukan dengan metoda snowball sampling. Hasil penelitian didapatkkan sebanyak 25 famili, yang terdiri dari 46 spesies dan 2691 individu tanaman obat. Famili yang banyak ditemukan jumlah spesies dan individunya adalah Zingeberaceae, merupakan famili yang banyak ditemukan jumlah spesies dan individunya. Spesies yang memiliki kelimpahan tertinggi adalah Sauropus androgynus, kemudian Zingiber officinale dan Curcuma longa. Indek kekayaan, keanekaragaman dan kemerataan spesies tertinggi pada pekarangan Suku Jawa. Bentuk hidup tanaman obat yang paling banyak ditemukan adalah herba dan perdu. Daun merupakan bagian tanaman yang banyak dimanfaatkan untuk tanaman obat dan proses pengolahan umumnya dengan cara direbus. Pemanfaatan tanaman obat pekarangan oleh masyarakat dapat digunakan untuk mengobati 18 jenis penyakit.Kata kunci: Tanaman obat; Zingiberaceae, Sauropus androgynus, herba. ABSTRACTMedicinal plants are plants that have active components and are believed by the community to cure diseases. This study aims to analyze the diversity and utilization of medicinal plants in the yard in North Dumoga, Bolaang Mongondow Regency, North Sulawesi. The sampling method used was purposive sampling. The selection of respondents was carried out using the snowball sampling method. The results of the study were 25 families, consisting of 46 species and 2691 individual medicinal plants. The family with the highest number of species and individuals was Zingeberaceae, which was the family with the highest number of species and individuals. The species with the highest abundance were Sauropus androgynus, then Zingiber officinale and Curcuma longa. The highest index of species richness, diversity and evenness was in the Javanese tribe. The most common forms of medicinal plant life are herbs and shrubs. Leaves are part of a plant that is widely used for medicinal plants and in general processing by boiling. The use of yard medicinal plants by the community can be used to treat 18 types of diseases.Key words: Medicinal plants; Zingiberaceae, Sauropus androgynus, herb.
Hydroponic Garlic Production: An Overview
Authors: Ali Muhammad Fraz , Ali Ummar , Jamil Muhammad Ahsan , Awais Muhammad , Khan Muhammad Jazib , Waqas Muhammad , Adnan Muhammad 
Published: April 2021

Introduction: Garlic is an important crop growing all around the globe for its nutritional and medicinal purpose. Due to climate change soil production of garlic is affected and thus lower in yield. For improving the yield and increasing the quality of vegetables a new technique was developed is called hydroponic technology.
Review results: In hydroponic, garlic can be produced on condition basis by providing proper nutrition and growth environment including air, light, soilless mediums, and water requirements. Methods like deep water culture, nutrient film technique, drip irrigation, bubble ponics are very common under different soilless mediums which includes organic, inorganic and synthetic. A detailed overview on production technology, nutrition, medium and hydroponic techniques which are discussed in details are given below in this review.
Fertilization the Omission One Test as Determination Limiting Factors for Maize Biomass (Zea mays L.)
Authors: Tampubolon Koko , Azmi Bagus Fitra , Tamba Perdana Andriano , Lestari Ayu Widya , Kamaruddin Kamaruddin , Lestari Eka , Ginting Tommy Suranta 
Published: April 2021

Introduction: The research was aimed to obtain information on the impact of omission one test fertilization as a determination limiting factors for the growth and biomass of maize in variety Bonanza F1.
Materials and Methods: The research was located in the experimental field, Faculty of Agriculture and Animal Husbandry, Universitas Tjut Nyak Dhien, Medan from December 2020 until February 2021. The research was applied by Randomized Block Design in non-factorial through fertilization of omission one test that has been converted (urea : SP-36 : KCl = 0.75 : 0.50 : 0.125 g polybag-1). The treatment of this research include P0 = non-fertilization; P1= N+P+K; P2= P+K; P3= N+K; P4= N+P using three replications. The parameters include plant height, leaf growth, total fresh weight, total dry weight, and the percentage of relative yield then processed using ANOVA and continued with DMRT at 5% ± standard error with SPSS v.20 software.
Results: Informed that the omission one test technique significantly improved all the characteristics of maize in the variety Bonanza F1. The highest increase in plant height was found in the N+P of 83.65%, meanwhile, the highest leaf and biomass growth characters were found in N+P+K, ranged of 50.00 to 177.81% and 487.60 to 507.37%, respectively. It was obtained that the limiting factor for the maize growth in variety Bonanza F1 was found in the un-fertilization of nitrogen.
Empati Dan Penerimaan Sosial Siswa Reguler Terhadap Siswa ABK
Authors: Sandra Okta Novrika , Zuhroh Lutfiatuz 
Published: April 2021

Banyak terjadi kasus penolakan siswa reguler terhadap siswa ABK dengan alasan perbedaan dan keterbatasan yang dimilikinya. Siswa reguler belum mampu memahami keadaan siswa ABK dengan segala keterbatasannya, mereka memandang siswa ABK dengan kacamata mereka sebagai siswa normal, tanpa mencoba membayangkan bagaimana jika mereka yang berada di posisi siswa ABK. Penelitian ini bertujuan untuk mengetahui hubungan empati dan penerimaan diri siswa reguler terhadap siswa ABK di kelas inklusif SD Inklusif Ulil Albab Kepanjen. Penelitian ini menggunakan metode kuantitatif dengan menggunkan teknik analisis data korelasi product moment. Sampel penelitian ini berjumlah 53 siswa reguler, dimana subjek merupakan siswa reguler yang kebetulan ditemui dan cocok sebagai sumber data. Terdapat dua alat ukur yang digunakan adalah (1) skala empati dan (2) skala penerimaan sosial.Dari hasil penelitian dan pembahasan disimpulkan bahwa hipotesis peneiltian ini diterima. Hal ini menandakan empati berkorelasi positif dengan penerimaan sosial. Sehingga semakin tinggi tingkat empati maka semakin tinggi pula tingkat penerimaan sosial siswa reguler terhadap siswa ABK di kelas inklusif SD Inklusif Ulil Albab.
<b>Beneficios socioeconómicos de las familias que pertenecen a las concesiones forestales comunitarias en Petén, Guatemala</b><br/><i>Socio-economic benefits of families belonging to community forestry concessions in Petén, Guatemala<i>
Authors: Corzo Amilcar , Figueroa Idida M. , Rodríguez Deysi L. 
Published: April 2021

Las concesiones forestales comunitarias creadas en la década de 1990 son una estrategia de conservación en la Reserva de la Biósfera Maya. La evidencia de monitoreo de la cobertura boscosa indica un impacto positivo en la conservación de los bosques. Para identificar si el impacto positivo también se refleja en el bienestar socioeconómico de los concesionarios, se hizo un estudio con 1229 hogares de miembros concesionarios y un grupo de comparación no concesionario. El estudio analiza el impacto socioeconómico a nivel de hogar de la pertenencia a los grupos concesionarios en comparación con grupos sin concesión. La evidencia indica que si bien el efecto no es muy grande los grupos que pertenecen a las concesiones tienen mayor ingreso, mejores condiciones de hogar, acceso a servicios de salud, mayor acceso a educación y percepciones sobre los recursos naturales y su conservación más afines a la teoría conservacionista. Pese a que hay diferencias socioeconómicas a favor de las concesiones, el acceso a esos beneficios es menor en las concesiones que se encuentran dentro de la Reserva que en los grupos concesionarios urbanos viviendo fuera de ella. Si se desea garantizar los beneficios de las concesiones,es necesario no solo focalizarse en el aspecto forestal, sino también mejorar los procesos sociales, económicos y administrativos.
<b>Análisis de la justicia de los jueces de paz en los municipios de Chacsinkín y Tahmek, Yucatán </b><br/><i> Justice Analysis of the judges of peace in the Municipalities of Chacsinkín and Tahmek, Yucatán<i>
Authors: Bolio Ortiz, Héctor Joaquín 
Published: April 2021

La justicia maya representa una forma de entender la manera de dar solución a conflictos dentro de una comunidad. Ésta ha existido a lo largo de la historia, pero como cualquier institución social se ha ido transformando con el transcurso de los años. Para el caso del Estado de Yucatán, se creó la Ley del Sistema de Justicia Maya en 2014, lo que, de alguna manera, permite que las poblaciones mayas del Estado den solución a algunos de sus conflictos jurídicos. No obstante, el problema se observa cuando esta forma de justicia está acotada desde las altas esferas gubernamentales y no responde a las necesidades de las comunidades originarias.
<b>Establecimiento de la institución cofradial en Cualac, Guerrero, México 1696-1738 </b><br/><i> Establishment of the cofradial institution in Cualac, Guerrero, México 1696-1738<i>
Authors: Sosa Rodríguez Gabriela Mahelet 
Published: April 2021

El presente trabajo tiene la finalidad de analizar el contexto de instauración de la Cofradía del Santísimo Sacramento en un pueblo conocido durante la época virreinal como Qualaq (Cualac). Pretende arrojar luz sobre la interrogante que gira en torno al origen de una cofradía mixta en un asentamiento de origen nahua de difícil acceso, y por tanto, considera los aspectos sociales y económicos que se articulan al proceso de evangelización. La relevancia del estudio radica en el uso de fuentes documentales inéditas provenientes del curato de Cualac, sitio en donde fueron identificados diversos volúmenes relacionados con el desempeño de la institución eclesial en el transcurso de las centurias coloniales, información que ha permitido develar algunos aspectos relativos a la historia de la serranía oriente de Guerrero.
Cine del Holocausto y resiliencia: El Pianista, Korczak, Cenizas y Diamantes
Authors: Yela Fernández Otto Roberto 
Published: April 2021

La resiliencia es la habilidad de encontrar e incrementar nuestras fuerzas internas luego de enfrentarnos a una experiencia traumática o adversa. También es la capacidad de adaptación frente a la adversidad, generando cambios internos que nos permiten aceptar, sobrellevar y sobreponernos al trauma.Los valores resilientes ponen a trabajar los motores internos de la gente y son el punto de partida para infundirle ánimos en sus propias fuerzas. El estudio propone coadyuvar a estos procesos con la implementación de una posible herramienta de ejemplificación, identificación y transmisión de valores resilientes: el cine.La propuesta responde a las preguntas: ¿Puede el cine incrementar la resiliencia de las personas? ¿Es posible llevar a cabo un proceso de revisión de valores resilientes presentes en las películas, con el objetivo de incorporarlos a los imaginarios de los espectadores? ¿Podemos considerar al cine como una herramienta útil en los procesos de descubrimiento y afirmación de los valores resilientes de las personas? ¿Es posible auspiciar la resiliencia de los centroamericanos con herramientas como el cine?A partir de un análisis semiótico de las películas, se definen las cualidades resilientes de los personajes, las cuales son examinadas a razón de los contextos históricos y sociales que dieron lugar a los hechos bélicos de violencia extrema que les tocó vivir. Los resultados de tal análisis revelan las etapas del desarrollo psicosocial que los personajes tuvieron que superar para llegar a ser resilientes, así como los valores que hubieron de incorporar como requisitos previos.