bluuebunny/crossref_metadata_2025_split huggingface dataset:
Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients
Authors: Hassin Ori , Nataraj Nishanth Belugali , Shreberk-Shaked Michal , Aylon Yael , Yaeger Rona , Fontemaggi Giulia , Mukherjee Saptaparna , Maddalena Martino , Mallel Giuseppe , Gershon Anat , Grosheva Inna , Feldmesser Ester , Golani Ofra , Blandino Giovanni , Kelsen David , Yarden Yosef , Oren Moshe 
Published: June 2021

Abstract
Colorectal cancer (CRC) is the third most common cancer worldwide. The TP53 gene is mutated in approximately 60% of all CRC cases. Sporadic CRC is characterized by high prevalence of TP53 hotspot missense mutations. In particular, over 20 percent of all TP53-mutated CRC tumors carry either the p53R175H structural mutant or the p53R273H DNA contact mutant. Importantly, clinical data analysis suggests that CRC tumors harboring p53 R273 mutations are more prone to progress to metastatic disease than those with R175 mutations, in association with decreased survival. By combining in vitro CRC cell line models and human CRC data mining, we identified a unique transcriptional signature orchestrated by p53R273H, implicating activation of oncogenic signaling pathways and predicting worse patient outcome. Concordantly, p53R273H selectively promotes rapid CRC cell spreading, migration and invasion in vitro and metastasis in vivo. Mechanistically, the transcriptional output of p53R273H is associated with, and presumably driven by, its preferential binding to regulatory elements of R273 signature genes. Together, this demonstrates that different TP53 missense mutations contribute differently to cancer progression, and that p53R273H possesses distinct gain-of-function activities in CRC that bear on disease course and possibly on patient management strategy. Given that practically all current analytical cancer gene panels include TP53, elucidation of the differential impact of distinct TP53 mutations on disease features is expected to make information on TP53 mutations more actionable and holds potential for better precision-based medicine.
Meta-analysis of Salt Valproate Prevent Switch Associated with Antidepressants in Chinese Depressive Patients
Authors: Shen Dong , Lv Wangqiang , Sun Fengli , Weidong Jin 
Published: June 2021

Abstract
Objective: to study the efficacy of valproate in preventing switch rate related to antidepressant in depressive patients. Methods: The related literature were searched in Chinese Biomedical Database(CBM), China National Knowledge Infrastructure(CNKI) , WANFANG database,and Chinese Social Sciences Citation Index(CSSCI) from 1 January 2005 to 1 January 2020 The rate of switch between groups was synthesized and discussed.Result:A total of 549 subjects were included in 7 studies,in which in 279 cases are in combination group and 270 cases are in group of monotherapy by antidepressant . The results showed switch rate of valproate group was 0.11%,switch rate of antidepressant group was 11.11%, which was very different (OR=0.13 ,95% CI: 0.05–0.35) and also indicated that valproate reduced switch rate was 99%[ (11.11%-0.11%)/11.11%]. In sodium valproate group, switch rate was 0%，while switch rate in antidepressant was 5.7%( OR=0.18,95%CI=0.04-0.84,Z=2.18,P=0.03). In magnesium valproate group, switch rate was 2.2%,while switch rate in antidepressant was16.92% ( OR=0.11,95%CI=0.03-0.39,Z=3.47, P=0.0005).Conclusion:The salt valproate can reduced switch rate related to antidepressant in depressive patients.
Ceramic Material based Optical Antenna for Multiband Photonics Applications
Authors: Sharma Anand , Prajapati Yogendra Kumar , Tripathi Devendra Kumar 
Published: June 2021

Abstract
In this article, design and development of a multiband ceramic material-based Optical antenna is discussed. Square shaped aperture is utilized to excited silicon based dielectric resonator. This type of excitation system provides the capability to create triple hybrid mode (HEM11δ, HEM12δ and HEM11δ+2) inside the cylindrical shaped ceramic material. Due to this feature, the proposed aerial is operating over diverse frequency bands i.e. 117.5-140 THz, 158-165.5 THz and 175.2-190.5 THz respectively. Stable radiation characteristics as well as good value of gain (about 4.0 dBi) makes the proposed Nano-radiator applicable for hyper spectral imaging system (125 THz) and VLC for wireless LAN (160/180THz).
Factors Associated With Body Image Satisfaction Among Palestinian University Female Students, Cross-Sectional Study
Authors: Alwafa Reem Abu , Badrasawi Manal 
Published: June 2021

Abstract
Background

Eating disorders and body dysmorphic disorder are linked to poor body image. People with these diseases commonly lack the ability to objectively assess body shape, size, or attractiveness. This study aimed to investigate the relationship between body image, eating disorders, lifestyle, social pressure, and social media engagements in female university students in Palestine.
Method:

A sample of 905 female undergraduate students from Palestinian universities was included in the study. Arabic validated Body Appreciation Scale (BAS-2) was used to measure body satisfaction. Early screening of eating disorders was conducted using the Arabic validated A-SCOFF tool. One-way ANOVA, independent t-test, Chi-square, Spearman rho correlation test, and simple linear regression tests were used to evaluate the relationships between study variables.
Results

The sample had a high level of body image satisfaction, with a mean score of 4.22 ± 0.74. It was found that eating disorders (p < .001), higher BMI (p < .001), following models or celebrities on social media (p < .01), following models or celebrities nutritional advice (p < .05), family and friends pressure (p < .001), dieting (p < .001), and daily phone hours (p < .01) were associated with lower body satisfaction. While physical activity (p < .05) was associated with higher body satisfaction.
Conclusion

Body image among female university students is influenced by lifestyle, social pressure, and social media. To promote awareness about the impact of these variables on body dissatisfaction, which can lead to eating disorders, educational and supporting programs must be undertaken.
Evaluation of Asymptomatic Bacteruria Management Before and After Antimicrobial Stewardship Program Implementation: Retrospective Study
Authors: Alghamdi Ahlam , Almajed Majed , Alalawi Raneem , Alganame Amjad , Alanazi Shorooq , Alghamdi Ghaida , Alharthi Salman , Alghamdi Isra 
Published: June 2021

Abstract
BackgroundThe Infectious Diseases Society of America (IDSA) recommends against screening for and/or treating asymptomatic bacteriuria (ASB). This study aims to evaluate the inappropriate use of antibiotics in ASB before and after Antimicrobial Stewardship Program implementation and advance towards its appropriate use. MethodWe performed a retrospective study of patients diagnosed with ASB from 2016 to 2019 at a tertiary hospital in Saudi Arabia. This study included hospitalized patients ≥18 years old who had a positive urine culture with no signs or symptoms of urinary tract infection and were on antibiotics for asymptomatic bacteriuria. We excluded pregnant women, solid organ transplant patients, patient on active chemotherapy, and patients about to undergo urological surgery.ResultsA total of 716 patients with a positive urine culture were screened . Among these, we identified 109 patients with ASB who were enrolled in our study. The rate of inappropriate antibiotic use was 95% during the study period. The implementation of the Antimicrobial Stewardship Program was associated with a significant reduction in the use of carbapenems (P = 0.04) and an increase in the use of cephalosporins (P = .099687). However, overprescribing antimicrobial agents was a concern in both eras. Approximately 90% of the microorganisms identified were gram-negative bacteria. Of those, 38.7% were multidrug-resistant strains. ConclusionThe urine culture order in ASB is considered relatively small number; however, it showed a high rate of the inappropriate use of antibiotics when there is an order of urine culture in both era. ASP ought to focus on targeting the ordering physician, promoting awareness and/or organizational interventions that appear to reduce the incidence of overtreatment.
Oxidative and Salt Stresses Alter the 26S Proteasome Holoenzyme and Associated Protein Profiles in Arabidopsis Thaliana
Authors: Bonea Diana , Noureddine Jenan , Gazzarrini Sonia , Zhao Rongmin 
Published: June 2021

Abstract
Background: The 26S proteasome, canonically composed of multi-subunit 19S regulatory (RP) and 20S core (CP) particles, is crucial for cellular proteostasis. Proteasomes may be re-modeled, activated, or re-localized and this regulation is critical for plants in response to environmental stresses. The proteasome holoenzyme assembly and dissociation are therefore highly dynamic in vivo. However, the stoichiometric changes of the plant proteasomes and how proteasome associated chaperones vary under common abiotic stresses have not been systematically studied.Results: Here, we studied the impact of abiotic stresses on proteasome structure, activity, and interacting partners in Arabidopsis thaliana. We analyzed available RNA expression data and observed that expressions of proteasome coding genes varied substantially under stresses; however, the protein levels of a few key subunits did not change significantly within 24 hours. Instead, a switch in the predominant proteasome complex, from 26S to 20S, occurs under oxidative or salt stress. Oxidative stress also reduced the cellular ATP content and the association of HSP70-family proteins to the 20S proteasome, but enhanced the activity of cellular free form CP. Salt stress, on the other hand, did not affect cellular ATP level, but caused subtle changes in proteasome subunit composition and impacted bindings of assembly chaperones. Analyses of an array of T-DNA insertional mutant lines highlighted important roles for several putative assembly chaperones in seedling establishment and stress sensitivity. We also observed that knockout of PBAC1, one of the a-ring assembly chaperones, resulted in hypersensitivity and tearing of the seed coat during sterilization. Conclusions: Our study revealed an evolutionarily conserved mechanism of proteasome regulation during oxidative stress, involving dynamic regulation of the holoenzyme formation and associated regulatory proteins, and we also identified a novel role of the PBAC1 proteasome assembly chaperone in seed coat development.
The Evolution Characteristics of Different Deformation Modes of Shear Slip Surface Based on Acoustic Emission Measurements
Authors: Xie Qiang , wu zhihui , Ban Yuxin , Fu Xiang , Cao Zhilin , Sun Weichen , Chen Bolin 
Published: June 2021

Abstract
To investigate the acoustic emission (AE) precursor detection of landslide failures, a model test aiming at reproducing the typical shear surface deformation of different landslide modes was designed. The evolution characteristics of the AE signals were analyzed in terms of AE count, cumulative AE count, AE correlation diagrams, and corresponding time-frequency properties. The test results show that for the progressive deformation mode, the AE count experiences a low-level period, an active period and a rapid increase period, and the distribution of correlation diagram hits concentrates in a relatively small scale and then gradually scatters. There is low frequency signals firstly and then high frequency signals, and the energy proportion of the high-frequency signals shows an increasing tendency. For the sudden deformation mode, the magnitude of AE count increases sharply, leading to the cumulative AE count curve rises steeply, and correlation diagram hits distribution turns into relatively scattering rapidly. Furthermore, the high frequency signals and high energy proportion appear much earlier than that of the progressive deformation mode. For steady deformation mode, however, the acoustic emission activity is quite active in the initial stage, the cumulative AE count curve rises sharply and then maintains relatively flat trend, and correlation diagram hits distribution scatters firstly, then the signal hits distribution begins to concentrate in a relatively small scale. There are intensive high-frequency hits and high energy proportion earlier, and later they tend to decay in response to smaller magnitudes of movement. Comprehensive use of multiple features can help identify landslide deformation patterns more accurately under complex natural conditions, which may provide a promising reference for the field warning monitoring of the diverse landslide failures.
Rethinking the Economic Costs of Hospitalisation for Malaria: Accounting for the Comorbidities of Malaria Patients in Western Kenya
Authors: Watts Caroline , Atieli Harrysone , Alacapa Jason , Lee Ming-Chieh , Zhou Guofa , Githeko Andrew , Yan Guiyun , Wiseman Virginia 
Published: June 2021

Abstract
BackgroundMalaria causes significant mortality and morbidity in sub-Saharan Africa, especially among children under five years of age and places a huge economic burden on individuals and health systems. While this burden has been assessed previously, few studies have explored how malaria comorbidities affect inpatient costs. This study in a malaria endemic area in Western Kenya, assessed the total treatment costs per malaria episode including comorbidities in children and adults.MethodsTotal economic costs of malaria hospitalisations were calculated from a health system and societal perspective. Patient-level data were collected from patients admitted with a malaria diagnosis to a county-level hospital between June 2016 and May 2017. All treatment documented in medical records were included as health system costs. Patient and household costs included direct medical and non-medical expenses, and indirect costs due to productivity losses.ResultsOf the 746 patients admitted with a malaria diagnosis, 64% were female and 36 % were male. The mean age was 14 years (median 7 years). The mean length of stay was three days. The mean health system cost per patient was Kenyan Shilling (KSh) 4,288 (USD 42.0) (95% confidence interval (CI) 95%CI KSh 4,046-4,531). The total household cost per patient was KSh 1,676 (USD 16.4) (95%CI KSh 1,488-1,864) and consisted of: KSh 161 (USD1.6) medical costs; KSh 728 (USD 7.1) non-medical costs; and KSh 787 (USD 7.7) indirect costs. The total societal cost (health system and household costs) per patient was KSh 5,964 (USD 58.4) (95%CI KSh 5,534- 6,394). Almost a quarter of patients (24%) had a reported comorbidity. The most common malaria comorbidities were chest infections, diarrhoea, and anaemia. The inclusion of comorbidities compared to patients with-out comorbidities led to a 46% increase in societal costs (i.e. health system costs increased by 43% and patient and household costs increased by 54%). ConclusionsThe economic burden of malaria is increased by comorbidities which are associated with longer hospital stays and higher medical costs to patients and the health system. Understanding the full economic burden of malaria is critical if future malaria control interventions are to protect access to care, especially by the poor.
Telemedicine application in patient with Diabetes, Hypertension and Rheumatoid arthritis：A systematic review and meta-analysis
Authors: Ma Yue , Zhao Yan , Zhao Chongbo , Lu Jiahong , Jiang Hong , Cao Yanpei , Xu Yafang 
Published: June 2021

Abstract
Background: Under the global epidemic condition，the telemedicine was widely used in the world, especially in the period of long-term care and treatment. The aim of study is to verify the effectiveness of telemedicine in the management of chronic disease by using scientific methods such as hypertension, diabetes, rheumatoid arthritis by using Meta-analysis and systematic review methods. The purpose of this study was to systematic review of the effect of telemedicine in chronic disease, so as to provide inspiration for chronic disease management in the future.Methods: Article searching were performed using Web of Science, PubMed, MEDLINE, EMBASE and other library or database to retrieve articles which published from database and library establishment to October 31st, 2020. Literature quality assessment, systematic review and Meta-analysis were then performed.Results: 12 articles were included in the literature quality assessment (7 diabetes,3 hypertensions,2 rheumatoid arthritis), the article included in this study is of high quality. There are 7 articles included in the Meta-analysis, the result shows there have effect in glycosylated hemoglobin after 12 months of intervention (95%CI=-1.53, -0.16; Z=2.42; P=0.02), compare with 6 months (95%CI=-1.32, -0.01; Z=1.99; P=0.05). It also showed that there was no significant difference in fasting blood glucose after 6 months of intervention (95%CI=-1.19,0.21; Z=1.37; P=0.17). Both systolic blood pressure (95%CI=-12.79, -3.69; Z=3.55; P= 0.0004) and diastolic blood pressure (95%CI=-9.90, -0.43; Z=2.14; P= 0.03) showed statistically significant. Moreover, we also found positive influence of telemedicine about good behaviors and rehabilitation for rheumatoid arthritis patients.Conclusion: The results showed that telemedicine had a positive effect on the management of diabetes, hypertension and rheumatoid arthritis, especially on the management of glycosylated hemoglobin and blood pressure. Telemedicine technologies have great promotion to access the medical services and improve the quality of care, especially for people with chronic diseases.
Chitosan-Glutathione Nanoparticles Modify Hepatic Cellular Response on Bovine Precision-cut Liver Slices Treated With Zilpaterol and Clenbuterol.
Authors: Olmos Sofìa Piña , Hernández Mariana Dolores , Torres Roberto Díaz , Bribiesca J. Efrén Ramírez , Arellano Raquel López , Noguera Patricia Ramírez 
Published: June 2021

Abstract
Zilpaterol and clenbuterol are two β-adrenergic agonist drugs used on animal production. Both drugs have anabolic effects with advantages on carcass yield. Meanwhile, zilpaterol is approved for animal feed in authorized countries; clenbuterol is a banned substance due to the risk of toxicity; however, it is still being used at unknown dose levels in many farm species. Therefore, the use and abuse of these substances should be closely monitored, considering the clenbuterol ability and the not proven yet of zilpaterol to produce reactive oxygen (ROS) and nitrogen species. Regarding glutathione which is the main intracellular antioxidant and plays detoxification functions on liver metabolism; case study is a primary interest to know the capacity of chitosan-glutathione nanoparticles (CS/GSH-NP) as a complementary source of exogenous GSH to modify the oxide-reduction status on bovine precision-cut liver slice cultures exposed to clenbuterol and zilpaterol. A single drug assay was performed in the first instance by adding clenbuterol, zilpaterol, chitosan nanoparticles (CS-NP), and CS/GSH-NP. Then combinate drug assay was carried out by testing clenbuterol and zilpaterol combined with CS-NP or CS/GSH-NP. The results showed that both agonist β-adrenergic modify in a dose-dependent manner oxide-reduction response through ROS generation, glutathione peroxidase activity, and intracellular GSH content; and de release of liver enzymes associated with hepatocellular damage like gamma glutamyl-transpeptidase, aspartate aminotransferase, alanine aminotransferase. The exogenous GSH delivered by nanoparticles could be used to modulate these markers.
Early changes in quantitative ultrasound imaging parameters during neoadjuvant chemotherapy to predict recurrence in patients with locally advanced breast cancer
Authors: Bhardwaj Divya , Dasgupta Archya , DiCenzo Daniel , Brade Stephen , Fatima Kashuf , Quiaoit Karina , Trudeau Maureen , Gandhi Sonal , Eisen Andrea , Wright Frances , Look-Hong Nicole , Curpen Belinda , Sannachi Lakshmanan , Czarnota Gregory 
Published: June 2021

Abstract
Background: This study was conducted in order to explore the use of quantitative ultrasound (QUS) based higher-order texture derivatives in predicting recurrence for patients with locally advanced breast cancer (LABC) early during neoadjuvant chemotherapy (NAC). Methods: Eighty-three patients with LABC were scanned with 7 MHz ultrasound before starting NAC (week 0) and during treatment (week 4). Spectral parametric maps were generated corresponding to tumor volume. Twenty-four textural features (QUS-Tex1) were determined from parametric maps acquired using grey-level co-occurrence matrices (GLCM) for each patient, which were further processed to generate 64 texture derivatives (QUS-Tex1-Tex2), leading to a total of 95 features from each time points. Analysis was carried out on week 4 data and compared to baseline (week 0) data. ∆Week 4 data was obtained from the difference in QUS parameters, texture features (QUS-Tex1), and texture derivatives (QUS-Tex1-Tex2) of week 4 data and week 0 data. Patients were divided into two groups based on their clinical status: recurrence and no-recurrence. Machine learning algorithms using k-nearest neighbor (k-NN) and support vector machines (SVM) were used to generate radiomic models. Results:  With a median follow up of 69 months (range 7-118 months), 28 patients had disease recurrence. The k-NN classifier was the best performing algorithm at week 4 with sensitivity, specificity, accuracy, and area under curve (AUC) of 87%, 75%, 81%, and 0.83, respectively. The inclusion of texture derivatives (QUS-Tex1-Tex2) in week 4 QUS data analysis led to the improvement of the classifier performances. The AUC increased significantly from 0.70 (without texture derivatives) to 0.83 (with texture derivatives). The most relevant features in separating the two groups were higher-order texture derivatives obtained from scatterer diameter and acoustic concentration-related parametric images.  Conclusion: This is the first study highlighting the utility of QUS radiomics in the prediction of recurrence during the treatment of LABC. It reflects that the ongoing treatment-related changes can predict clinical outcomes with higher accuracy as compared to pretreatment features alone.  Clinical Trial Registration: ClinicalTrials.gov Identifier: NCT00437879 .Registry name: Clinicaltrials.gov.Date of registration: 20th February 2007URL: https://clinicaltrials.gov/ct2/show/study/NCT00437879