bluuebunny/crossref_metadata_2025_split huggingface dataset:
External Validation of the Radiographic Investigation of the Distal Extension of Fractures Into the Articular Surface of the Tibia (RIDEFAST Study)
Authors: Rane Ajinkya , Jacobson Lance Glen , Kellam Patrick , Marchand Lucas Scott , Working Zachary M. , Steimle Jerrod A. , Higgins Thomas F. , Rothberg David Lynn , Weber Timothy G. , Haller Justin 
Published: January 2021

Objective:
To test the external validity of the fracture to plafond (FTP—length of fracture/distance to plafond) ratio to rule out distal intra-articular fractures (DIA) in distal tibial shaft fractures at an independent tertiary trauma center.

Design:
Retrospective cohort study.

Setting:
Two Level 1 trauma centers.

Patients:
Two hundred seventeen patients with a distal tibial shaft fracture in the model cohort and 146 patients in the validation cohort.

Intervention:
Radiographic measurements to calculate FTP ratio.

Main Outcome Measurements:
Calibration plots, area under receiver operating characteristic curve (AUC), and decision curve analyses to evaluate the external validity of FTP ratio to determine DIA.

Results:
The AUC for the anteroposterior (AP) FTP ratio was 0.83 [95% confidence interval (CI) 0.78–0.88] in the model data set and 0.86 (95% CI 0.80–0.91) in the validation data set. The AUC for the lateral FTP ratio was 0.82 (95% CI 0.77–0.87) in the model data set and 0.82 (95% CI 0.75–0.88) in the validation data set. The previously established AP FTP cutoff ratio of 0.61 had a 94% negative predictive value in the model cohort and a 100% negative predictive value in the validation cohort.

Conclusion:
The FTP ratio is an effective and externally validated screening tool to rule out DIA in distal tibia shaft fractures.

Level of Evidence:
Diagnostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Cartilaginous Dorsum Repositioning Technique
Authors: Azimov Gorkhmaz 
Published: January 2021

Background:
Hump (dorsum) reduction is one of the most desired outcomes of primary rhinoplasty. However, serious complications relating to the current methods exist. Reduction of the nasal spine by way of traditional rhinoplasty leads to destruction of the nasal anatomy, and reconstruction is needed for aesthetic and functional reasons. As a result, the natural anatomy of the nose becomes altered dramatically. The purpose of this study was to demonstrate that the preservation of only the cartilaginous part of the nasal dorsum was possible during hump reduction.

Methods:
From September 2018 to December 2019, the author performed a total of 210 rhinoplasties using a cartilaginous dorsum repositioning technique (CDRT). Statistical analysis was also performed.

Results:
CDRT resulted in relatively limited edema and more rapid patient recovery in comparison with the traditional rhinoplasty technique used. No serious complications were observed using this new technique.

Conclusions:
This technique allows for the treatment of almost 90% of primary rhinoplasty patients, without destruction of the cartilaginous portion of the nasal dorsum and septum cartilage, and allows us to save nasal anatomy almost in its entirety. At the same time, we are able to obtain great aesthetic results.
Recalcitrant Anaphylaxis Associated with Fibrin Sealant: Treatment with “TISSEEL-ectomy”
Authors: Saffarzadeh Mohammadali , Mulpuri Anvith , Arneja Jugpal S. 
Published: January 2021

Summary:
Here, we present the case of an adolescent male who developed a severe allergic reaction 10 minutes after application of TISSEEL fibrin sealant to control bleeding during a gynecomastia revision surgery. Conventional treatments of acute hypersensitivity were ineffective. After a “tisseel-ectomy,” the patient’s condition improved and symptoms resolved. Besides oral tranexamic acid, and topical and local anaesthesia, no other medications besides TISSEEL were administered preceding the allergic reaction. After TISSEEL was identified as the allergen upon its removal, his clinical status improved. The patient had been exposed to TISEEL 15 months before the anaphylactic episode. This case can aid in decision-making for surgical re-exposure to fibrin sealants in the setting of acute anaphylaxis.
Partial-Thickness Intrastromal Lamellar Keratoplasty for Corneal Pellucid Marginal Degeneration
Authors: Gonçalves Thiago B. , Nosé Angela F. B. , Pereira Nicolas C. , Forseto Adriana dos S. 
Published: January 2021

Purpose:
Pellucid marginal degeneration (PMD) is a bilateral corneal ectatic disorder, characterized by thinning of the inferior cornea. Numerous surgical procedures have been described in the literature, and there is a lack of consensus regarding the best available surgical management. Recently, full-thickness intrastromal lamellar keratoplasty (ILK) was described as an option for treating PMD and emerged as a promising technique. However, ILK results in an irregular surface, leading to a significant residual against-therule (ATR) astigmatism.

Methods:
This study describes a variation of the ILK technique, using a partial-thickness graft to treat 2 cases of PMD.

Results:
At the final follow-up, both patients improved visual acuity and had their mean simulated keratometry flattened, although a residual ATR astigmatism remained.

Conclusions:
The ILK technique modification might lead to a more regular thickness pattern, although it did not seem efficient in reducing the ATR astigmatism.
Lung-protective ventilation and adjunctive strategies to manage respiratory failure: are they safe in the neurological patient?
Authors: Piran Pirouz , Stevens Robert D. 
Published: January 2021

Purpose of review
The coexistence of neurological injury and respiratory failure is common in intensive care. This article provides a contemporary overview of the safety and efficacy of different strategies for mechanical ventilation and adjunctive respiratory approaches in patients with acute brain injury.

Recent findings
Available evidence indicates that lung-protective ventilation (LPV) can be implemented safely in a range of patients with concurrent respiratory failure and brain injury of different etiologies; however, the clinical efficacy of LPV in this setting needs to be established. In patients who have severe acute respiratory distress syndrome (ARDS) and brain injury, adjunctive measures (neuromuscular blocker drug infusions, prone positioning, extracorporeal membrane oxygenation) may be considered, although the neurophysiological impact and safety of these techniques need further investigation. Intracranial pressure and other neuromonitoring techniques may be of value to ensure optimal management of mechanical ventilation and adjunctive measures in this population.

Summary
Research is needed to determine the safety, feasibility, and efficacy of LPV and adjunctive approaches for managing patients with concurrent brain injury and respiratory failure.
Postauricular injection in the treatment of all-frequency and high frequency descending sudden hearing loss
Authors: Li Ying , Liang Jiao , Chiang Han-Jen , Liu Yang 
Published: January 2021

Abstract

Background:
Sudden hearing loss (SHL) is a disease, at the same time a symptom, which needs to be treated in a timely manner and counts as an emergency health problem in the Department of Otolaryngology. There are many types of sudden hearing loss and among them, the occurrence of all-frequency descending sudden hearing loss and high frequency sudden hearing loss are high. The conventional treatment for these 2 types of sudden hearing loss sometimes is not as effective as expected. Postauricular injection of glucocorticoids could be the most effective treatment method. However, the effectiveness and safety of postauricular injection of glucocorticoid needs to be assessed systematically.

Methods:
The protocol for the meta-analysis was conducted under the guidance of Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). The aim is to undertake a systematic review and meta-analysis on the effectiveness and safety of postauricular injection of glucocorticoid to treat patient diagnosed with all-frequency and high frequency descending sudden hearing loss. We searched through the following databases: English databases (PubMed, EMBASE, Web of Science) and Chinese databases (CNKI, Wanfang databases, CBM, VIP). The final selected articles will be evaluated using Cochrane RCT evaluation criteria. Revman 5.0 will be used for data analysis. Subgroup analysis, sensitivity analysis, and meta regression will detect sources of heterogeneity. Ethics approval was not required for this protocol. The findings will be disseminated through journal articles or conference presentations.

OSF registration number:
DOI 10.17605/OSF.IO/5Q9NA

Results:
Objectively, evaluate the efficacy and safety of postauricular injection of glucocorticoid in treating all-frequency descending sudden hearing loss and high frequency sudden hearing loss.

Conclusion:
To provide evidence-based medicine for glucocorticoid treatment methods in patients with all-frequency descending sudden hearing loss and high frequency descending hearing loss.
Value of anti-hepatitis B virus in serum tested by enzyme linked immunosorbent assay 3 in diagnosis of hepatitis B
Authors: Fei-fei Shen , Xiao-dan Ren , Hai-qiang Liu , He-wei Zhang 
Published: January 2021

Abstract

Introduction:
This protocol is for a meta analysis that aims to systematically review the diagnostic value of anti-hepatitis B virus in serum tested by the enzyme linked immunosorbent assay in patients with hepatitis B.

Methods and analysis:
The following electronic databases will be searched from inception to Mar 2021: PubMed, Web of Science, ScienceDirect, EMBASE, MEDLINE, Springer, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, VIP Chinese Science and Technology Periodical Database, and Wanfang Database. All study about enzyme linked immunosorbent assay reagents have been published at home and abroad to diagnose hepatitis B virus will be included. MetaDisc 1.4 soft will used to calculate pooled effect size in sensitivity, specifi city, likelihood ratio, diagnostic odds ratio and summary receiver operating characteristic curve, and area under the curve as well.

Ethics and dissemination:
Formal ethical approval is not required, as the data are not individualized. The findings of this systematic review will be disseminated in a peer-reviewed publication and/or presented at relevant conferences.

Registration number:
INPLASY2020100051.
Prenatal detection of terminal 9p24.3 microduplication encompassing DOCK8 gene
Authors: Yue Fagui , Yu Yang , Zhang Xinyue , Jiang Yuting , Li Leilei , Liu Ruizhi , Zhang Hongguo 
Published: January 2021

Abstract
Trisomy 9p is one of the most common chromosomal partial trisomies in newborns. However, reports on prenatal 9p microduplications are rare in the clinic. This study aimed to examine the genotype–phenotype correlation and assess the clinical significance of 9p24.3 microduplication encompassing the DOCK8 gene. Eight pregnant women underwent amniocentesis for cytogenetic and genetic testing for various indications for prenatal diagnosis from January 2019 to January 2020. Chromosomal karyotypic analysis was performed on G-band metaphases that were prepared from cultured amniotic fluid cells. Chromosomal microarray analysis was carried out to detect chromosomal copy number variations. We also performed a literature review on clinical data on similar 9p24.3 microduplications to determine the genotype–phenotype correlation. We detected 123–248-kb microduplications in the region of 9p24.3 (chr9: 208454–469022), involving part of or the entire DOCK8 gene. The indications for prenatal diagnosis mainly focused on the risk of maternal serum screening for trisomy 21/18, advanced maternal age, and increased nuchal translucency. No evident structural abnormalities were observed for all fetuses, except for case 5 who presented with increased nuchal translucency in prenatal ultrasound findings. Follow-up of postnatal health was performed and showed no apparent abnormalities for cases 1 to 6 after birth. The parents of case 7 chose to terminate the pregnancy while the parents of case 8 chose to continue the pregnancy. We propose that 9p24.3 microduplications that encompass part of or the entire DOCK8 gene are variants that might be benign. However, further large-scale studies are necessary to evaluate the clinical pathogenicity. For prenatal cases with 9p24.3 microduplication, postnatal health and growth should be followed up and assessed regularly from childhood to adulthood.
The benefits of Qigong exercise for symptoms of fatigue
Authors: Wang Rui , Huang Xueyan , Wu Yeqi , Sun Dai 
Published: January 2021

Abstract

Background:
About 5% to 20% of the general population suffers from continuous fatigue, which is also one of the most frequent symptoms seen in primary medical care. Fatigue, if not effectively relieved, may have an adverse effect on the quality of life and treatment of patients. Qigong is a safe and comfortable exercise popular in China and among the Ethnic Chinese, and is a complementary therapy used to treat fatigue, such as cancer related fatigue and chronic fatigue syndrome. It appears promising but lacks convincing evidence; thus, necessitating further investigation.

Methods:
Eight databases (PubMed, Web of Science, Embase, Cochrane Library, China Biology Medicine disc, China National Knowledge Infrastructure, WanFang and VIP Data Knowledge Service Platform) will be searched from inception to November 30, 2020 for randomized controlled trials published in English or Chinese investigating the outcomes of the Qigong exercise (QE) for symptoms of fatigue and quality of life. We will also include additional references of relevant published studies by manually retrieving reference lists of included literature and previous relevant reviews. For articles that meet the inclusion criteria, 2 reviewers will independently conduct the study selection, data extraction, and risk of bias assessment. The results of the outcome measures will be reported in risk ratios for dichotomous data and standard mean differences for continuous data. If necessary, we will also perform subgroup analyses and analyze the causes.

Results:
The results of this review will be submitted to a journal for publication.

Conclusion:
This systematic review protocol aims to analyze whether QE is effective in treating fatigue associated with various disease.

Registration:
INPLASY2020110133.
Clinicopathologic characteristic and prognosis in idiopathic membranous nephropathy patients with focal segmental sclerosis lesion
Authors: Cheng Wenrong , Sun Lijun , Dong Hongrui , Wang Guoqin , Ye Nan , Wang Yanyan , Cheng Hong 
Published: January 2021

Abstract
To explore the clinicopathological characteristics and prognosis of idiopathic membranous nephropathy (IMN) with focal segmental sclerosis lesions (FSL).
A total of 70 IMN patients with FSL (FSL+group) were enrolled in this study, and 140 patients were randomly selected by age and sex matching as disease controls (FSL-group). The clinical and renal histopathological data on renal biopsy and clinical data of patients regularly followed were collected. Serum anti-phospholipase A2 receptor (PLA2R) autoantibody, thrombospondin type-1 domain-containing 7A (7A) autoantibody, glomerular PLA2R and 7A expression, and IgG4 deposition were detected. First, the clinical and pathological significance of IMN combined with the FSL group was analyzed. Whether FSL is a risk factor for renal outcomes was further analyzed.
IMN patients who developed FSL had more severe clinical and pathological characteristics than those without FSL. FSL was an independent risk factor for poorer prognosis. When the appearance of FSL in IMN patients with a high level of serum anti-PLA2R antibody, the treatment needs to be more aggressive to promote remission and to delay the progression of renal function.
CHADS2, CHA2DS2-VASc, ATRIA, and Essen stroke risk scores in stroke with atrial fibrillation
Authors: Yu Inwu , Song Tae-Jin , Kim Bum Joon , Heo Sung Hyuk , Jung Jin-Man , Oh Kyung-Mi , Kim Chi Kyung , Yu Sungwook , Park Kwang Yeol , Kim Jeong-Min , Park Jong-Ho , Choi Jay Chol , Park Man-Seok , Kim Joon-Tae , Hwang Yang-Ha , Chung Jong-Won , Bang Oh Young , Kim Geong-Moon , Kim Yong-Jae , Kim Seonwoo , Woo Sook young , Cho Hyun , Seo Woo-Keun 
Published: January 2021

Abstract
The performance of scoring systems for risk stratification in patients with atrial fibrillation (AF) was not validated well in patients with stroke. The purpose of this study was to evaluate whether the risk scoring systems predict vascular outcomes in stroke patients with AF.
Data were obtained from a nationwide multicenter registry for acute stroke with AF from January 1, 2013, to December 31, 2015. We investigated the predictive power of the CHADS2, CHA2DS2-VASc, ATRIA, and Essen stroke scores in stroke patients with AF. The subjects were further stratified into groups according to treatment with or without oral anticoagulants (OACs).
A total of 3112 stroke with AF subjects were included. The rate of recurrent ischemic stroke and any stroke were not associated with the CHADS2, CHA2DS2-VASc, ATRIA, and Essen stroke risk scores. The risks of death and major adverse cerebrovascular and cardiovascular events (MACEs) increased sequentially with the increase of each risk score in OAC group. (the range of C-index 0.544–0.558 for recurrent ischemic stroke; 0.523–0.537 for any stroke; 0.580–0.597 for death; 0.564–0.583 for MACEs). However, in the group treated with OACs, all risk scores were significantly associated with the risk of MACEs. The C-statistics of the 4 scoring systems were 0.544 to 0.558, 0.523 to 0.537, 0.580 to 0.597, 0.564 to 0.583, respectively, for recurrent ischemic stroke, any stroke, death, and MACEs.
The performance of the CHADS2, CHA2DS2-VASc, ATRIA, and Essen stroke risk scores for the prediction of recurrent stroke was unsatisfactory in stroke patients with AF whereas the performance for the prediction of recurrent stroke was not MACEs or death was good. A new risk stratification scheme that is specific for secondary stroke prevention in the AF population is needed.
Prenatal diagnosis of fetal congenital mesoblastic nephroma by ultrasonography combined with MR imaging
Authors: Che Meiling , Yang Fan , Huang Huilin , Zhang Hongyang , Han Cong , Sun Nao 
Published: January 2021

Abstract

Rationale:
Fetal congenital mesoblastic nephroma (CMN) is a rare renal tumor, characterized by polyhydramnios, premature birth, and neonatal hypertension. In the prenatal stage, it is particularly difficult to diagnose CMN either by ultrasonography or magnetic resonance imaging (MRI). Thus, CMN is frequently detected in the third trimester in the clinical scenario.

Patient concerns:
A 29-year-old G2P0 pregnant woman took routine prenatal examinations in our hospital. The fetal right kidney abnormality was not observed after 2 systematical ultrasonic examinations (at 24 and 31 weeks of gestation respectively), and only an increase was noticed in the amniotic fluid index (from 19.3 to 20.8 cm).

Diagnosis:
CMN was detected by antenatal ultrasonography and MRI as a fetal right renal mass at 35 weeks of gestation in our hospital.

Interventions:
The pregnant woman was admitted at a gestational age of 38 weeks and 5 days due to alterations in renal function. Further, the pregnant woman was administered with “oxytocin” to promote delivery, and the neonate underwent a right nephrectomy on the 9th day after birth.

Outcomes:
The pathological examination confirmed a cellular type of right CMN. The neonate recovered well after operation without adjuvant treatment. During 6 months of follow-up, the neonate grew well and showed no signs of recurrence or metastasis.

Conclusion:
Polyhydramnios detected during prenatal examination required attention due to the risk of malformation of fetal urinary system. Prenatal ultrasonography combined with MRI could not only clearly identify the origin of the tumor, but also distinguish the correlation between the tumor and adjacent structures, thereby leading to early diagnosis and favorable prognosis.
The potential impact from glenohumeral internal rotation deficit to the knee kinematics in baseball pitchers
Authors: Cheng Shih-Chung , Lin Shu-Ming , Lin Won-Jean 
Published: January 2021

Abstract
A recent study suggested that baseball pitchers with glenohumeral internal rotation deficit (GIRD) may tend to use trunk rotation as compensation to adjust ball placement, which may lead to subsequent counter movement at the knee of the leading leg.

This study aims to investigate the kinematic characteristics of the counter movements between the femur and the tibia (knee torsion), from the landing of the leading leg until the follow-through phase, during throwing between pitchers with and without GIRD at the dominant arm.
This is a case-control study. Twenty-one senior high school baseball pitchers were recruited in this study. The glenohumeral internal and external rotation, hip internal and external rotation of all participants were measured. Eight pitchers without GIRD and 13 pitchers with GIRD were enrolled into the control group and experiment group, respectively. The maximal angular movement between the femur and the tibia (knee torsion) of the leading leg was measured, using The Zebris 3D (Zebris Medizintechnik GmbH, Isny, Germany) motion analysis system, in the interval from the landing until the follow-through phase during pitching a fastball to the bottom-outside corner with their dominant arm.
The results showed that the maximal knee torsion of the leading leg in the experimental group (13.67 ± 0.9 degrees) was significantly greater than the control group (4.25 ± 1.369 degrees) (P < .05).
Pitchers with GIRD had greater counter movement in the knee joint than pitchers without GIRD.
Nursing effect of ECMO combined with CRRT in the treatment of fulminant myocarditis
Authors: Wu Juan , Zhang Hui , Gao Yongxia , Huang Xihua 
Published: January 2021

Abstract

Background:
Fulminant myocarditis has a sudden onset and rapid progress, which can easily cause multiple organ failure. Acute kidney injury is a common complication. ECMO (extracorporeal membrane oxygenation) and CRRT (continuous renal replacement therapy) have been used in the treatment of fulminant myocarditis, but the combination of the 2 has an impact on the prognosis. There is still a big controversy. Therefore, the purpose of this randomized controlled trial is to evaluate the nursing effect and long-term efficacy and safety of ECMO combined with CRRT in the treatment of fulminant myocarditis.

Methods:
This is a prospective randomized controlled trial to study the effectiveness and safety of ECMO combined with CRRT in the treatment of fulminant myocarditis. Approved by the clinical research ethics committee of our hospital. Patients were randomly assigned to 1 of 2 treatment options:
Observation indicators include: basic vital signs, laboratory indicators, echocardiographic changes, complications, and outcomes. SPSS 25.0 (Chicago, IL) version statistical software package was used to analyze the data.

Discussion:
This study will evaluate the nursing effect and long-term efficacy and safety of ECMO combined with CRRT in the treatment of fulminant myocarditis. The results of this experiment will provide clinical evidence for the treatment of fulminant myocarditis with ECMO and CRRT.

Ethics and dissemination:
Private information from individuals will not be published. This systematic review also does not involve endangering participant rights. Ethical approval was not required. The results may be published in a peer-reviewed journal or disseminated at relevant conferences.

OSF Registration number:
DOI 10.17605/OSF.IO/PAQBZ.