bluuebunny/crossref_metadata_2025_split huggingface dataset:
P2P Lenders versus Banks: Cream Skimming or Bottom Fishing?
Authors: de Roure Calebe , Pelizzon Loriana , Thakor Anjan 
Published: December 2021

Abstract
We derive three testable predictions from a bank-P2P lender model of competition: (a) P2P lending grows when some banks are faced with exogenously higher regulatory costs; (b) P2P loans are riskier than bank loans; and (c) the risk-adjusted interest rates on P2P loans are lower than those on bank loans. We test these predictions against data on P2P loans and the consumer bank credit market in Germany and find empirical support. Overall, our analysis indicates that P2P lenders are bottom fishing, especially when regulatory shocks create a competitive disadvantage for some banks. (JEL G21)
Recovering Investor Expectations from Demand for Index Funds
Authors: Egan Mark , MacKay Alexander , Yang Hanbin 
Published: December 2021

Abstract
We use a revealed-preference approach to estimate investor expectations of stock market returns. Using data on demand for index funds that follow the S&P 500, we develop and estimate a model of investor choice to flexibly recover the time-varying distribution of expected future returns across investors. Our analysis is facilitated by the prevalence of leveraged funds that track the same underlying asset: by choosing between higher and lower leverage, investors trade off higher return against less risk. Our estimates indicate that investor expectations are heterogeneous, extrapolative, and persistent. Following a downturn, investors become more pessimistic on average, but there is also an increase in disagreement among participating investors due to the presence of contrarian investors.
A tribute to Robert Croyle, PhD, Director, Division of Cancer Control and Population Sciences
Authors: Rimer Barbara K 
Published: December 2021

Abstract
At the beginning of Dr. Robert Croyle’s 18th and final year as director of the National Cancer Institute’s (NCI) Division of Cancer Control and Population Sciences (DCCPS), before his retirement in December 2021, it is fitting to review some of his and the division’s many accomplishments and pay tribute to him as one of the government’s most effective leaders. The focus of this article is on Dr. Croyle’s contributions in the behavioral and related domains and his and the division’s impact on the landscape of cancer control and population sciences. Dr. Croyle joined DCCPS in 1998 as associate director for behavioral research. He became acting director of DCCPS in 2001 and then director in 2003. DCCPS is a formidable NCI division, with broad mandates and responsibilities and many partners from multiple sectors. The division conducts and supports an integrated program of the highest-quality genetic, epidemiological, behavioral, social, applied, survivorship, surveillance, and health care delivery cancer research. The division’s notable successes in implementation science and the dissemination of evidence-based findings and products, use of cancer research consortia, and partnerships across National Institutes of Health and with external federal and nongovernmental organizations are among many that reflect Dr. Croyle’s visionary leadership.
The new genus Aglaona: the first abyssal aglajid (Heterobranchia: Cephalaspidea: Aglajidae) with a description of two new species from the north-western Pacific Ocean
Authors: Chaban Elena M , Ekimova Irina A , Schepetov Dimitry M , Chernyshev Alexei V 
Published: December 2021

Abstract
In this paper we describe the new genus Aglaona, the first abyssal genus of the family Aglajidae, comprising two new species: Aglaona rudmani sp. nov. from the Sea of Okhotsk (inhabiting a depth of 3206 m) and Aglaona valdesi sp. nov. from the Pacific slope of the Kuril Islands (at a depth of 3374–3580 m). For species descriptions and inference of relationships, we have followed an integrative approach, including molecular phylogenetic analyses based on four markers (COI, 16S, H3 and 28S) and a morphological analysis based on traditional anatomical dissections and scanning electron microscopy. The new genus is characterized by a well-developed radula with marginal teeth (2:1:0:1:2) and an internal bulloid shell with a wing-like parietal callus. External and internal morphology of Aglaonagen. nov. species is similar to that of the philinoid genus Laona (family Laonidae). Phylogenetic analyses support the inclusion of the new genus in the family Aglajidae, but its sister-relationships are unresolved. Our results suggest that Aglaonagen. nov. possesses several plesiomorphic characters, and that the reduction of shell and radula in Aglajidae occurred in parallel in different lineages.
Effectiveness and durability of protection against future SARS-CoV-2 infection conferred by COVID-19 vaccination and previous infection; findings from the UK SIREN prospective cohort study of healthcare workers March 2020 to September 2021
Authors: Hall Victoria , Foulkes Sarah , Insalata Ferdinando , Saei Ayoub , Kirwan Peter , Atti Ana , Wellington Edgar , Khawam Jameel , Munro Katie , Cole Michelle , Tranquillini Caio , Taylor-Kerr Andrew , Hettiarachchi Nipunadi , Calbraith Davina , Sajedi Noshin , Milligan Iain , Themistocleous Yrene , Corrigan Diane , Cromey Lisa , Price Lesley , Stewart Sally , de Lacy Elen , Norman Chris , Linley Ezra , Otter Ashley David , Semper Amanda , Hewson Jacqueline , D’Arcangelo Silvia ,   the SIREN Study Group, Chand Meera , Brown Colin S , Brooks Tim , Islam Jasmin , Charlett Andre , Hopkins Susan 
Published: December 2021

ABSTRACTBackgroundUnderstanding the duration and effectiveness of infection and vaccine-acquired SARS-CoV-2 immunity is essential to inform pandemic policy interventions, including the timing of vaccine-boosters. We investigated this in our large prospective cohort of UK healthcare workers undergoing routine asymptomatic PCR testing.MethodsWe assessed vaccine effectiveness (VE) (up to 10-months after first dose) and infection-acquired immunity by comparing time to PCR-confirmed infection in vaccinated and unvaccinated individuals using a Cox regression-model, adjusted by prior SARS-CoV-2 infection status, vaccine-manufacturer/dosing-interval, demographics and workplace exposures.ResultsOf 35,768 participants, 27% (n=9,488) had a prior SARS-CoV-2 infection. Vaccine coverage was high: 97% had two-doses (79% BNT162b2 long-interval, 8% BNT162b2 short-interval, 8% ChAdOx1). There were 2,747 primary infections and 210 reinfections between 07/12/2020 and 21/09/2021. Adjusted VE (aVE) decreased from 81% (95% CI 68%-89%) 14-73 days after dose-2 to 46% (95% CI 22%-63%) >6-months; with no significant difference for short-interval BNT162b2 but significantly lower aVE (50% (95% CI 18%-70%) 14-73 days after dose-2 from ChAdOx1. Protection from infection-acquired immunity showed evidence of waning in unvaccinated follow-up but remained consistently over 90% in those who received two doses of vaccine, even in those infected over 15-months ago.ConclusionTwo doses of BNT162b2 vaccination induce high short-term protection to SARS-CoV-2 infection, which wanes significantly after six months. Infection-acquired immunity boosted with vaccination remains high over a year after infection. Boosters will be essential to maintain protection in vaccinees who have not had primary infection to reduce infection and transmission in this population.Trial registration numberISRCTN11041050
Plasmodiophora brassicae in Mexico, from anecdote to fact
Authors: Padrón-Rodríguez Legnara , Cerdán Cabrera Carlos Roberto , Sánchez Coello Nadia Guadalupe , Luna-Rodríguez Mauricio , Pérez-López Edel 
Published: December 2021

ABSTRACTFor years, the presence of clubroot disease and its causal agent, Plasmodiophora brassicae, in Mexico has been given by granted. However, after a long search in the scientific literature in English and Spanish, as well as grey literature including thesis and government reports, we were not able to find any information regarding the actual detection of the pathogen, hosts affected, areas with the disease, or any real information about clubroot (‘hernia de la col’, in Mexico). To confirm if P. brassicae was indeed in Mexico, we started a true detective adventure. First, we identified agricultural communities in south-east Mexico known to grow cruciferous crops. Second, we asked to the growers if they have ever seen clubroot symptoms, showing them during the inquires pictures of the characteristic galls that might have been present in their crops. Third, we collected soil from two of the communities with positive response and grew an array of cruciferous in the soil as baits to “fish” the clubroot pathogen. We detected the presence of galls in the roots of 32 plants and observed the presence of resting spores. Through a P. brassicae specific PCR assay, we were able to confirm the presence of the clubroot pathogen in the samples and in Mexico for the very first time. This study is the first report and identification of P. brassicae in Mexico, opening the doors to understand the genetic diversity of this elusive and devastating plant pathogen.
The impact of murine cytomegalovirus (mCMV) route and age at infection upon virus spread, immune responses and the establishment of latency
Authors: Coplen Christopher P. , Jergovic Mladen , Terner Elana L. , Uhrlaub Jennifer L. , Nikolich-Žugich Janko 
Published: December 2021

ABSTRACTCytomegalovirus (CMV) is a ubiquitous human virus, which establishes a characteristic lifetime infection in its host. Murine CMV (mCMV) is a widely-used infection model that has been employed to investigate the nature and extent of CMV’s contribution to inflammatory, immunological, and health disturbances in humans. In an effort to assess the role of route and age in modeling hCMV infection in mice, we have performed a comparative analysis of two common experimental modes of infection (intraperitoneal and intranasal) at two different clinically relevant ages (4 weeks, or prepubescent childhood equivalent, and 12 weeks, or young postpubescent adult). We found that while both routes of infection led to similar early viral loads, differential activation of several parameters of innate immune function were observed. In particular, younger, prepubescent mice exhibited the strongest NK activation in the blood in response to i.p. infection, with this trend holding true in NK cells expressing the mCMV-specific receptor Ly49H. Moreover, i.p. infected animals accumulated a larger amount of anti-mCMV IgG and experienced a greater expansion of both acute and latent phase CD8+T cells. This was especially true for young postpubescent mice, further illustrating a distinction in the bloodborne immune response across not only infection routes, but also ages. These results may be important in the understanding of how a more physiologically applicable model of CMV influences immunity, inflammation, and health over the lifespan.
The Importance of Mentors and How to Handle More Than One Mentor
Authors: Marshall Andrea G. , Brady Lillian J. , Palavicino-Maggio Caroline B. , Neirkirk Kit , Vue Zer , Beasley Heather , Garza-Lopez Edgar , Murray Sandra , Martinez Denise , Shuler Haysetta , Spencer Elsie C. , Morton Derrick , Hinton Antentor 
Published: December 2021

ABSTRACTIntroductionWorking with multiple mentors is a critical way for students to expand their network, gain opportunities, and better prepare for future scholastic or professional ventures. However, students from underrepresented groups (UR) are less likely to be mentored or have access to mentors, particularly in science, technology, engineering, and mathematics (STEM) fields. We developed and implemented a workshop, to provide the necessary foundation for students to be better prepared for establishing future mentorships throughout graduate and professional school.MethodsFaculty well-versed in the area of effective mentorship from multiple universities developed and delivered a 1.5-hour workshop to address the roles of a mentor, especially when it comes to UR students, and how students may effectively work with multiple mentors. This workshop was delivered to a group of students from the HBCU Winston Salem State University, and a pre/post-Likert scale-based survey was administered.ResultsWe analyzed the raw data with nonparametric tests for comparison within paired samples. Wilcoxon matched-pairs and signed-rank tests showed statistically significant growth in student self-ratings related to the workshop learning objectives.ConclusionsThe “How to Handle More than One Mentor to Achieve Excellence” workshop was well received as a component of pre-graduate and pre-professional training. Incorporating workshops like this may increase student preparedness around developing and cultivating healthy mentorship relationships throughout STEM training.EDUCATIONAL OBJECTIVESBy the end of this workshop, learners will be able to:Describe the role of mentors in developing the next generation of trainees.Describe current research on mentorship among underrepresented populations.Apply skills on effective communication needed in the development of successful mentorship relationships.Work with multiple mentors at one time while maintaining solid professional and personal relationships.
In silico study on the effects of disulfide bonds in ORF8 of SARS-CoV-2
Authors: Cheng Yadi , Peng Xubiao 
Published: December 2021

AbstractThe COVID-19 epidemic, caused by virus SARS-CoV-2, has been a pandemic and threatening everyone’s health in the past two years. In SARS-CoV-2, the accessory protein ORF8 plays an important role in immune modulation. Here we present an in silico study on the effects of the disulfide bonds in ORF8, including the effects on the structures, the binding sites and free energy when ORF8 binds to the human leukocyte antigen (HLA-A). Using the explicit solvent Molecular Dynamics (MD) simulations, we collect the conformational ensembles on ORF8 with different disulfide bonds reduction schemes. With a new visualization technique on the local geometry, we analyze the effects of the disulfide bonds on the structure of ORF8. We find that the disulfide bonds have large influences on the loop regions of the surface. Moreover, by performing docking between HLA-A and the conformational ensembles of ORF8, we predict the preferred binding sites and find that most of them are little affected by the disulfide bonds.Further, we estimate the binding free energy between HLA-A and ORF8 with different disulfide bonds reductions. In the end, from the comparison with the available experimental results on the epitopes of ORF8, we validated our binding sites prediction. All the above observations may provide inspirations on inhibitor/drug design against ORF8 based on the binding pathway with HLA-A.
Systematic evaluation of cell-type deconvolution pipelines for sequencing-based bulk DNA methylomes
Authors: Jeong Yunhee , Barros de Andrade e Sousa Lisa , Thalmeier Dominik , Toth Reka , Ganslmeier Marlene , Breuer Kersten , Plass Christoph , Lutsik Pavlo 
Published: December 2021

AbstractDNA methylation analysis by sequencing is becoming increasingly popular, yielding methylomes at single-base pair resolution. It has tremendous potential for cell-type heterogeneity analysis with intrinsic read-level information. Although diverse deconvolution methods were developed to infer cell-type composition based on bulk sequencing-based methylomes, the systematic evaluation has not been performed yet. Here, we thoroughly benchmark six previously published methods: Bayesian epiallele detection (BED), DXM, PRISM, csmFinder+coMethy, ClubCpG and MethylPurify, together with two array-based methods, MeDeCom and Houseman, as a comparison group. Sequencing-based deconvolution methods consist of two main steps, informative region selection and cell-type composition estimation, thus each was individually assessed. With these sophisticated evaluation, we demonstrate the method achieving the highest performance in different types of samples. We found that cell-type deconvolution performance is influenced by different factors depending on the number of cell types within the mixture. Finally, we propose a best-practice deconvolution strategy for sequencing data and limitations which need to be handled.
SARS-CoV-2-specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens
Authors: Bartolo Laurent , Afroz Sumbul , Pan Yi-Gen , Xu Ruozhang , Williams Lea , Lin Chin-Fang , Friedman Elliot S. , Gimotty Phyllis A. , Wu Gary D. , Su Laura F. 
Published: December 2021

AbstractThe baseline composition of T cells directly impacts later response to a pathogen, but the complexity of precursor states remains poorly defined. Here we examined the baseline state of SARS-CoV-2 specific T cells in unexposed individuals. SARS-CoV-2 specific CD4+T cells were identified in pre-pandemic blood samples by class II peptide-MHC tetramer staining and enrichment. Our data revealed a substantial number of SARS-CoV-2 specific T cells that expressed memory phenotype markers, including memory cells with gut homing receptors. T cell clones generated from tetramer-labeled cells cross-reacted with bacterial peptides and responded to stool lysates in a MHC-dependent manner. Integrated phenotypic analyses revealed additional precursor diversity that included T cells with distinct polarized states and trafficking potential to other barrier tissues. Our findings illustrate a complex pre-existing memory pool poised for immunologic challenges and implicate non-infectious stimuli from commensal colonization as a factor that shapes pre-existing immunity.One Sentence SummaryPre-existing immunity to SARS-CoV-2 contains a complex pool of precursor lymphocytes that include differentiated cells with broad tissue tropism and the potential to cross-react with commensal antigens.
Adolescent rats extend help to outgroup members, highlighting a neural network for group identity categorization
Authors: Breton Jocelyn M. , Eisner Jordan S. , Gandhi Vaidehi S. , Musick Natalie , Zhang Aileen , Long Kimberly L.P. , Perloff Olga S. , Hu Kelsey Y. , Pham Chau M. , Lalchandani Pooja , Barraza Matthew K. , Kantor Ben , Kaufer Daniela , Bartal Inbal Ben-Ami 
Published: December 2021

SummaryProsocial behavior, in particular helping others in need, occurs preferentially in response to the perceived distress of one’s own group members, or ingroup. The development of neural mechanisms underlying social selectivity towards ingroup members are not well established. Here, we used a rat helping behavior test to explore the development and neural basis of ingroup bias for prosocial behavior in adolescent rats. We previously found that adult rats selectively help others from their own social group, and that this selectivity is associated with activation in reward and motivation circuits. Surprisingly, we found that adolescent rats helped both ingroup and outgroup members, evidence suggesting that ingroup bias emerges in adulthood. Analysis of brain-wide neural activity, indexed by expression of the early-immediate gene c-Fos, revealed increased activity for ingroup members across a broad set of regions, which was congruent for adults and adolescents. However, adolescents showed reduced hippocampal and insular activity, and increased orbitofrontal cortex activity compared to adults. Adolescent rats who did not help trapped others also demonstrated increased amygdala connectivity. Together, these findings demonstrate that biases for group-dependent prosocial behavior develop with age in rats and suggest that specific brain regions contribute to this prosocial selectivity, overall pointing to possible targets for the functional modulation of ingroup bias.One Sentence SummaryProsocial selectivity increases with age in parallel with hippocampal and insular activation, providing insight into the neural classification of group membership.
Generalized distribution interpolated between the exponential and power-law distributions and applied to pill bug (Armadillidium vulgare) walking data
Authors: Shinohara Shuji , Okamoto Hiroshi , Moriyama Toru , Nakajima Yoshihiro , Shokaku Takaharu , Utsumi Akika , Chung Ung-il 
Published: December 2021

AbstractThe Lévy walk, a type of random walk in which the frequency of linear step-lengths follows a power-law distribution, can be observed in the migratory behavior of organisms at various levels, from bacteria and T cells to humans. Compared to the Brownian walk, which is also a type of random walk (characterized by an exponential distribution of the frequency of occurrence of step-length), the Lévy walk is characterized by the occasional appearance of linear movements over very long distances. In this paper, we propose a general distribution that includes the power-law and exponential distributions as special cases. This distribution has two parameters: the first parameter represents the exponent, similar to the power-law and exponential distributions and the second is a shape parameter representing the shape of the distribution. By introducing this distribution, an intermediate distribution model can be interpolated between the power-law and exponential distributions. The shape parameter measures whether a distribution assimilates a power-law or exponential distribution. In this study, the proposed distribution was fitted to the frequency distribution of the step-length calculated from the walking data of pill bugs. The autocorrelation coefficients were also calculated from the time-series data of the step-length, and the relationship between the shape parameter and time dependency was investigated. The results showed a significant negative correlation between the two (r=−0.61, n=30, t=4.04, and p=0.00037). This means that pill bugs with gait patterns closer to Lévy than Brownian walks have a stronger time dependence with respect to step-length changes.