bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and survival variations of upper tract urothelial cancer in Taiwan (2001–2010)
Authors: Lin Ming‐Yen , Niu Sheng‐Wen , Li Wei‐Ming , Lee Huei‐Lan , Chen Li‐Tzong , Wu Wen‐Jeng , Hwang Shang‐Jyh 
Published: October 2021

ObjectivesTo assess temporal patterns and regional differences in the incidence rate, and factors associated with survival of urinary tract urothelial carcinoma.MethodsThe medical records of 8830 patients with new diagnoses of urinary tract urothelial carcinoma in the years 2001–2010 were retrieved from Taiwan National databases. Temporal trends, regional disparity and related survival factors were evaluated using the Cochran–Armitage trend test, local Moran’s I statistic and log‐rank test, respectively.ResultsThe annual urinary tract urothelial carcinoma incidence rates (standardized by age) were steady at approximately 3.14–3.41 per 100 000 person‐years. Notably, women had a significantly higher annual urinary tract urothelial carcinoma incidence than men in most of the years studied (range of female‐to‐male annual standardized rate ratio: 2.08–3.25), and diabetes prevalence in urinary tract urothelial carcinoma increased significantly from 12.3% to 23.4% per year over the 10 years. High urinary tract urothelial carcinoma incidence cluster areas other than the latest endemic area of “blackfoot disease” were newly identified by local Moran’s I statistic (P < 0.05). Furthermore, older age, male sex, end‐stage kidney disease and more advanced tumor grade were associated with lower 5‐year overall survival probabilities in the 2001–2015 cohort.ConclusionsThe incidence and survival of urinary tract urothelial carcinoma over the decade 2001–2010 were different according to population and regional features. Various urinary tract urothelial carcinoma screening, prevention, treatment and care plans should be developed depending on age, sex, comorbidity and area of residence.
Power relations in global supply chains and the unequal distribution of costs during crises: Abandoning garment suppliers and workers during the COVID‐19 pandemic
Authors: ANNER Mark 
Published: October 2021

AbstractIn early 2020, apparel brands and retailers cancelled US$40 billion worth of orders, with critical consequences for suppliers and workers. Their actions illustrate the power asymmetries in global supply chains and the unequal distribution of costs during crises. This article explores these dynamics through original survey data, supplier questionnaires, stakeholder interviews, a time‐line analysis and trade data analysis. Findings point to certain limits of buyer power, reflected in the effective collaboration between suppliers and worker rights advocates in the “#PayUp” campaign. Yet buyers retain the power to squeeze suppliers with adverse impacts on workers, thus leading to calls for binding agreements.
Automatización, empleo y relocalización. ¿Disrupción en la industria de la confección?
Authors: BÁRCIA de MATTOS Fernanda , EISENBRAUN Jeff , KUCERA David , ROSSI Arianna 
Published: October 2021

ResumenEn un clima de preocupación por el impacto de la automatización en el empleo, hay consenso en que los puestos que implican tareas repetitivas codificables corren mayor riesgo. La industria de la confección ha sido estratégica para el desarrollo económico por dar acceso a los mercados mundiales y crear empleo. Aunque el trabajo rutinario es típico del sector, la penetración de las tecnologías de automatización sigue siendo limitada. Entrevistas a personal clave de grandes marcas de ropa ofrecen nuevas perspectivas sobre el uso actual y proyectado de tecnología, los bloqueos tecnológicos y las cuestiones de distribución global de la producción y del empleo.
The probiotic potential of Lactobacillus plantarum strain RW1 isolated from canine faeces
Authors: Raheem Abdul , Wang Mingyan , Zhang Jianwei , Liang Lin , Liang Ruiying , Yin Yajie , Zhu Yali , Yang Weifang , Wang Liang , Lv Xueze , Jia Yaxiong , Qin Tong , Zhang Guangzhi 
Published: October 2021

Abstract

Aim
To evaluation the probiotic potential of Lactobacillus plantarum strain RW1 isolated from healthy dogs for its further utilization as a dietary supplement for dogs.

Methods and Results
This study aimed to evaluate the probiotic potential of L. plantarum strain RW1 isolated from canine faeces. After confirming by conventional and then by 16S rRNA sequencing, the identified strain RW1 was in vitro screened for its survivability in simulated gastrointestinal conditions, low pH, bile salts and adhesion to gut epithelial tissues, growth inhibitory effects on common pathogens and anti-inflammatory potential by measuring the mRNA expression level of IL-6, IL-8, IL-1β in Salmonella-infected MODE-K cells. Furthermore, the effects on epithelial barrier function and host defensin peptide (beta-defensin 3) was studied by measuring the mRNA expression level of tight junction protein (occludin) and beta-defensin 3 in MODE-K cells. The strain RW1 showed a considerable potential to survive in simulated gastrointestinal environmental conditions, low pH and high bile salt concentrations along with good adhesion to MODE-K cell line. Pathogenic bacterial growth and their adhesion to MODE-K cell line were significantly inhibited by the strain RW1. Real-time PCR analyses demonstrated that the strain RW1 inhibited Salmonella-induced pro-inflammatory cytokines (IL-6, IL-8 and IL-1β) production and reinforced the expression of tight junction protein (occludin). The strain RW1 did not induce mRNA expression of beta-defensin 3.

Conclusion
Based on in vitro results, the strain RW1 has the potential to be used as a probiotic supplement in dogs. However, further study involving in vivo health effects is needed.

Significance and Impact of the Study
Antibiotics have many side effects and nowadays the probiotics are considered as a potential alternative to antibiotics. This study evaluates the probiotic potential of dog isolated L. plantarum strain RW1 to use it as a dietary supplement in dogs feeding to control infectious diseases.
Regulation of the innate immune cells during pregnancy: An immune checkpoint perspective
Authors: Li Wen‐Xuan , Xu Xiang‐Hong , Jin Li‐Ping 
Published: October 2021

AbstractThe foetus can be regarded as a half‐allograft implanted into the maternal body. In a successful pregnancy, the mother does not reject the foetus because of the immune tolerance mechanism at the maternal‐foetal interface. The innate immune cells are a large part of the decidual leukocytes contributing significantly to a successful pregnancy. Although the contributions have been recognized, their role in human pregnancy has not been completely elucidated. Additionally, the accumulated evidence demonstrates that the immune checkpoint molecules expressed on the immune cells are co‐inhibitory receptors regulating their activation and biological function. Therefore, it is critical to understand the immune microenvironment and explore the function of the innate immune cells during pregnancy. This review summarizes the classic immune checkpoints such as PD‐1, CTLA‐4 and some novel molecules recently identified, including TIM‐3, CD200, TIGIT and the Siglecs family on the decidual and peripheral innate immune cells during pregnancy. Furthermore, it emphasizes the role of the immune checkpoint molecules in pregnancy‐associated complications and reproductive immunotherapy.
Virulence and type III effector diversities of Xanthomonas citri pv. fuscans and X. phaseoli pv. phaseoli in Brazil
Authors: de Paiva Bruna Alicia Rafael , Wendland Adriane , Rossato Maurício , Velloso Ferreira Marisa A. da S. 
Published: October 2021

AbstractCommon bacterial blight (CBB) is caused by four genetic lineages belonging to two species of Xanthomonas, namely Xanthomonas citri pv. fuscans (includes fuscans, NF2 and NF3 lineages) and X. phaseoli pv. phaseoli (lineage NF1). A collection of 117 strains of Xanthomonas isolated from common bean plants grown in several producing regions of Brazil, between 2007 and 2016 was established. For species and lineage identification, the following tests were performed: multiplex PCR with a set of four specific primer pairs, pathogenicity tests on susceptible cultivar BRS Artico and phylogenetic analysis based on housekeeping gene sequences. The presence of the two species were confirmed among the 117 strains, being 62 non‐fuscans strains (NF1, NF2 and NF3) and 55 fuscans strains of X. citri pv. fuscans. To select a set of representative strains for the virulence assay, a PCR‐based analysis of effector diversity was performed with 42 strains belonging to the two species. PCR with primers for xopL, avrBsT, xopE2 and xopE1 genes were positive for all strains, while for the other six effectors there was variation. Six distinct effector profiles were detected, and one strain representing each type was inoculated in 15 common bean cultivars with varying levels of resistance to CBB. The fuscans strains showed uniformity in their effector profiles and were the most virulent. The phylogenetic analyses of our strain collection revealed that all genetic variants of CBB pathogens (NF1, NF2, NF3 and fuscans) are present in Brazil, with significant variability in virulence to common bean cultivars.
The use of plant extracts to control tilapia reproduction: Current status and future perspectives
Authors: Abaho Ivan , Masembe Charles , Akoll Peter , Jones Clifford L. W. 
Published: October 2021

AbstractControl of prolific reproduction is vital for a profitable tilapia aquaculture enterprise. All‐male tilapia culture is a popular method used to control prolific breeding, because the male individuals grow faster than female and mixed‐sex populations. Presently, most farmers use 17α‐methyl testosterone (MT) to produce all‐male tilapia individuals, although synthetic hormones are linked to human health and environmental risks. Recently, considerable attention has focused on plant‐based products as alternatives to MT, because they are affordable, safe, and eco‐friendly. Despite the growing interest in using plant extracts to prevent frequent spawning in tilapia production, the available information is not collated to standardize application guidelines. Accordingly, this review article consolidates existing knowledge on the use of plant extracts to control prolific breeding in tilapia culture systems. In addition, limitations to commercial application of the extracts are identified. To date, seed, root, and leaf extracts of 20 plant species, most notably, Tribulus terrestris, Mucuna pruriens, and Carica papaya, exhibit potential for controlling unwanted breeding in tilapia production systems. The extracts are mainly administered orally, incorporated in fish feeds. Saponins and flavanoids are the main bioactive compounds in the phytoextracts, which induce sex inversion and fertility impairment in tilapia. The commercialization of plant extracts is, however, hampered by lack of standardized information on extract preparation, optimal dosages, and mechanism of action. Thus, future studies should address these technical limitations and highlight economic incentives for commercial use of plant extracts in tilapia aquaculture.
CHOS gas/fluid‐induced reduction in ureilites
Authors: Langendam Andrew D. , Tomkins Andrew G. , Evans Katy A. , Wilson Nicholas C. , MacRae Colin M. , Stephen Natasha R. , Torpy Aaron 
Published: October 2021

AbstractUreilite meteorites contain regions of localized olivine reduction to Fe metal widely accepted to have formed by redox reactions involving oxidation of graphite, a process known as secondary smelting. However, the possibility that other reductants might be responsible for this process has largely been ignored. Here, 17 ureilite samples are investigated to assess whether, instead of smelting involving only solid reactants, a CHOS gas/fluid could have caused much of the smelting. Features consistent with gas‐ or supercritical fluid‐driven reduction were found to be abundant in all ureilites, such as fracture‐focused smelting, plume‐like reaction fronts, and addition of sulfur. Many of these are developed away from graphite. In some ureilites, it is clear that the redox process coincided with annealing, and we suggest that this was caused by enhanced diffusion facilitated by a higher density gas or fluid, rather than slow cooling, which requires elevated pressure. The C‐CO and CH4‐C‐H2O buffers were modeled to examine their relative potential to drive reduction. This modeling showed that a CH4‐rich fluid is able to produce the observed mineral compositions at elevated pressures. This result, coupled with the observed textures, is used to develop a likely series of reactions. We suggest that at higher pressures, a H2‐CH4‐H2S‐S2‐bearing fluid‐like phase, and at lower pressures, an equivalent gas, were able to infiltrate grain boundaries and fine fractures. Sulfidation to form troilite may have acted to maintain highly reduced gas/fluid conditions. The presence of hydrocarbons in ureilites supports a role for reduction driven by CHOS gas/fluid.
Correlation of Acetabular Anteversion and Thoracic Kyphosis Postoperatively with Proximal Junctional Failure in Adult Spinal Deformity Fused to Pelvis
Authors: Zhang Zi‐fang , Qi Deng‐bin , Wang Tian‐hao , Wang Zheng , Zheng Guo‐quan , Wang Yan 
Published: October 2021

ObjectivesTo investigate whether the immediate thoracic kyphosis (TK) and acetabular anteversion (AA) postoperatively are correlated with proximal junctional failure (PJF) in adult spinal deformity (ASD) patients underwent surgical treatment.MethodsThis is a retrospective study. Following institutional ethics approval, a total of 57 patients (49 Female, eight Male) with ASD underwent surgery fused to sacroiliac bone (S1, S2, or ilium) from March 2014 to January 2019 were included. All of those patients were followed up for at least 2 years. Demographic, radiographic and surgical data were recorded. The maximum range of flexion motion (F‐ROM) and extension motion (E‐ROM) actively of hip joints was measured and recorded at pre‐ and postoperation. The sum of F‐ROM and E‐ROM was defined as the range of hip motion (H‐ROM). Receiver operating characteristic (ROC) curve analysis was used to obtain the cut off value of parameters for PJF. A Kaplan–Meier curve and log‐rank test were used to analyze the differences in PJF‐free survival.ResultsIn all, 14 patients developed PJF during follow‐up. Comparisons between patients with and without PJF showed significant differences in immediate TK (P < 0.001) and AA (P = 0.027) postoperatively. ROC curve analysis determined an optimal threshold of 13° for immediate AA postoperatively (sensitivity = 74.3%, specificity = 85.7%, area under the ROC curve [AUC] = 0.806, 95% CI [0.686–0.926]). Nineteen patients with post‐AA ≤13° were assigned into the observational group, and 38 patients with post‐AA >13° were being as the control group. Patients in the observational group had smaller H‐ROM (P = 0.016) and F‐ROM (P < 0.001), but much larger E‐ROM (P < 0.001). There were 10 patients showing PJF in the observational group and four in the control group (10/9 vs 4/34, P < 0.001). PJF‐free survival time significantly decreased in the observational group (P = 0.001, log‐rank test). Furthermore, patients in the observational group had much larger TK (post‐TK, P = 0.015). The optimal threshold for post‐TK (sensitivity = 85.7%, specificity = 76.7%; AUC = 0.823, 95% CI [0.672–0.974]) was 28.1° after the ROC curve was analyzed. In the observational group, those patients with post‐TK ≥28.1° had significantly higher incidence of PJF (9/2 vs 1/7, P < 0.001) than those with post‐TK < 28.1°. Moreover, PJF‐free survival time in those patients significantly decreased (P = 0.001, log‐rank test).ConclusionsASD patients with acetabular anteversion of ≤13° at early postoperation may suffer significantly restricted hip motion and much higher incidence of PJF during follow‐up, moreover, in those patients, postoperative TK ≥28.1° would be a significant risk factor for PJF developing.
Changes in psychosocial factors among community‐dwelling older adults before and after Japan's declaration of a state of emergency over coronavirus disease 2019
Authors: Kubo Yuta , Noguchi Taiji , Hayashi Takahiro , Tomiyama Naoki , Ochi Akira , Hayashi Hiroyuki 
Published: October 2021

AbstractBackgroundSocial distancing measures to prevent the spread of coronavirus disease 2019 may cause changes in psychosocial factors. This study aimed to clarify changes in psychosocial factors among older adults before and after Japan's declaration of a state of emergency over coronavirus disease 2019.MethodsThis was a longitudinal cohort questionnaire study. A baseline survey was conducted in March 2020, and a follow‐up survey was conducted in August 2020. The subjects were 1103 community‐dwelling older adults not certified as having long‐term care needs who responded to both the baseline and follow‐up surveys. Changes in psychosocial factors before and after the state of emergency declaration were analysed by gender using the McNemar–Bowker test.ResultsData for 397 men (mean age ± standard deviation: 80.6 ± 4.7 years) and 486 women (80.3 ± 4.3 years) were analysed in this study. The frequency of meeting friends increased over the study period for men (P = 0.04). An increasing number of women lived alone (P = 0.01). However, many people's financial status improved (P < 0.01), and the number of friends met in the previous month increased (P < 0.01).ConclusionsNone of the examined psychosocial factors worsened, except for the increase in the number of women living alone. However, many of the study subjects refrained from engaging in certain activities. If the coronavirus disease 2019 pandemic persists, changes in psychosocial factors may occur. Therefore, a long‐term investigation of the secondary psychosocial effects of coronavirus disease 2019 is necessary.
Has the information and communication technology sector become the engine of China’s economic growth?
Authors: Huang Yongming , Khan Jamal 
Published: October 2021

AbstractThis study examines the key drivers of the information and communication technology (ICT) sector's growth and the dynamics of its sectoral relationships in the Chinese economy, about which little is known, by using four updated and harmonized input–output tables for the period 2002–2017. The decomposition analysis shows that the ICT sector's growth was mainly driven by the expansion of export and domestic demand in the 2002–2007 period and by domestic demand expansion in the 2007–2012 and 2012–2017 periods. Furthermore, causative matrix analysis demonstrates that the ICT sector was consistently externalized throughout the study period, regardless of whether it received limited feedback from non‐ICT sectors' final demand in the 2002–2007 and 2012–2017 periods or substantial feedback in the 2007–2012 period. Finally, linkage analysis reveals that the ICT sector has had profound intersectoral linkages with both supply‐ and demand‐side effects in the economy. We conclude that the ICT sector has been the engine of economic growth in China and that stimulating its growth is a key tool for economic development.
Using Maximum Simulated Likelihood Methods to Overcome Left Censoring: Dynamic Event History Models of Heart Attack Risk in New Zealand
Authors: Lee Sanghyeok , Gørgens Tue 
Published: October 2021

Abstract
This paper describes how the risk of experiencing heart attacks varies across gender and ethnicity in New Zealand. We estimate dynamic hazard models using administrative data. We deal with left-censored data using recently developed maximum simulated likelihood methods. The models allow risk to vary with age, previous heart attack history and unobserved individual heterogeneity. We find that the risk of subsequent events is far higher than the risk of the first event, particularly high within 1 year after an event, and that unobserved heterogeneity is important. Generally, male Maoris have the highest risk, followed by female Maoris, then ethnically European males, while ethnically European females have the lowest risk.
Feeling gutted in chronic kidney disease (CKD): Gastrointestinal disorders and therapies to improve gastrointestinal health in individuals CKD, including those undergoing dialysis
Authors: Biruete Annabel , Shin Andrea , Kistler Brandon M. , Moe Sharon M. 
Published: October 2021

AbstractChronic kidney disease (CKD) affects 9.1% of the population worldwide. CKD may lead to structural and functional gastrointestinal alterations, including impairment in the intestinal barrier, digestion and absorption of nutrients, motility, and changes to the gut microbiome. These changes can lead to increased gastrointestinal symptoms in people with CKD, even in early grades of kidney dysfunction. Gastrointestinal symptoms have been associated with lower quality of life and reduced nutritional status. Therefore, there has been considerable interest in improving gastrointestinal health in this clinical population. Gastrointestinal health can be influenced by lifestyle and medications, particularly in advanced grades of kidney dysfunction. Therapies focused on gastrointestinal health have been studied, including the use of probiotics, prebiotics, and synbiotics, yielding limited and conflicting results. This review summarizes the alterations in the gastrointestinal tract structure and function and provides an overview of potential nutritional interventions that kidney disease professionals can provide to improve gastrointestinal health in individuals with CKD.
Childhood Origins, Migration, and First Modern Contraceptive Use in Turkey
Authors: Erman Jeylan , Behrman Julia A. 
Published: October 2021

AbstractThis paper integrates contraception into the extant migrant‐fertility framework using the case of internal migration within Turkey. Drawing from the 2013 Turkish Demographic and Health Survey data, we show that migration is positively associated with age of first modern contraceptive use. As women's migration is quickly followed by family formation, women also take up modern contraception after first childbirth, likely due to new encounters with medical professionals, differing contraceptive access and other social exposures. We also find that women whose childhoods were spent in urban areas have a higher risk of first modern contraception relative to women from rural areas, thus suggesting the enduring importance of socialization. These results show how selection processes, life‐cycle factors, and sociocultural norms jointly shape modern contraceptive behavior in Turkey. Our results also demonstrate a need for increased reproductive care in rural areas and suggest continued fertility decline with urban migration.
Constructing Expertise: Surmounting Performance Plateaus by Tasks, by Tools, and by Techniques
Authors: Gray Wayne D. , Banerjee Sounak 
Published: October 2021

AbstractAcquiring expertise in a task is often thought of as an automatic process that follows inevitably with practice according to the log‐log law (aka: power law) of learning. However, as Ericsson, Chase, and Faloon (1980) showed, this is not true for digit‐span experts and, as we show, it is certainly not true for Tetris players at any level of expertise. Although some people may simply “twitch” faster than others, the limit to Tetris expertise is not raw keypress time but the techniques acquired by players that allow them to use the tools provided by the hardware and software to compensate for the game's relentlessly increasing drop speed. Unfortunately, these increases in drop speed between Tetris levels make performance plateaus very short and quickly followed by game death. Hence, a player's success at discovering, exploring, and practicing new techniques for the tasks of board preparation, board maintenance, optimal placement discovery, zoid rotation, lateral movement of zoids, and other tasks important to expertise in Tetris is limited. In this paper, we analyze data collected from 492 Tetris players to reveal the challenges they confronted while constructing expertise via the discovery of new techniques for gameplay at increasingly difficult levels of Tetris.