bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of occlusal connections in patients with congenital cleft lip and palate before and after their orthopedic rehabilitation
Authors: Ilyk Roman , Oliynyk Markiyan 
Published: October 2021

The aim of this study was to define and analyze the reproducibility of occlusal relationships according to the results of occlusogram in jaw closure using quantitative analysis of occlusion in adult patients with congenital cleft lip and palate before and after their prosthesis with different versions of dentures and types of their constructive features.
Materials and methods. The study was conducted on 37 patients with congenital cleft lip and palate, 11 (29.73 %) of whom had right-sided clefts, 11 (29.73 %) – left-sided and 15 (40.54 %) – bilateral.
The number of occlusal contact points was measured for all patients before the treatment and after the orthopaedic rehabilitation.
Research results. Significant differences were found between the number of occlusal contact points before (unusually small number) and after orthopaedic treatment (significant increase), regardless of the type of cleft (p<0.001). Such conditions in the oral cavity significantly complicate the tactics of orthopaedic rehabilitation, which affects the need to find more complex options for combinations of fixed and removable orthopaedic structures.
Conclusion. Based on the conditions and objectives of this study, the application of the basic principles of a multidisciplinary approach determine the possibility of rehabilitation of such patients by orthopedic methods by making different versions of orthopedic structures. Adequate and high-quality prosthesis for defects and deformations of the teeth rows and occlusion in patients with CCLP leads to improved occlusal relationships and increase in the number of occlusal contact points.
Creation of an observation network for assessment of the impact of the pig complex on the groundwater aquifer
Authors: Serdiuk Viktoriia , Maksin Viktor 
Published: October 2021

Ukraine, as a party to the Association Agreement, in accordance with Directive 2000/60/EC of the European Parliament and of the Council, recognizes water as the most expensive resource on our planet, which must be protected and saved. Every country and every inhabitant of the planet must do everything possible to reduce the thoughtless use of water and stop water pollution. The priority is the identification of water users and "polluters", as well as the detection and prevention of pollution of water resources, which includes the identification of water sampling points around potential sources of pollution. The aim of the research is to determine the impact of pig farms on the qualitative and quantitative characteristics of groundwater using existing water intakes to preserve natural water resources from pollution and depletion. An important point for monitoring in this situation is the use of existing water intakes (bores and wells) without additional construction of observation bores and interference in the environment. To complete the study, it is necessary to create an observation (monitoring) network of selected points and establish the frequency of their study. The observation network should determine the level (static and dynamic) as well as the quality of groundwater, which reflects background concentrations (natural or "conditionally natural"). "Conditionally natural" concentrations may indicate an excess of pollutants, associated with anthropogenic impacts that occurred prior to the activities of a particular entity, in respect of which the study is conducted. Given the changes in the quality characteristics of water, caused by external factors, "conditionally natural" concentrations can be taken as background. The obtained information will allow, depending on the quality and quantity of groundwater (their level) to make management decisions on the management of groundwater resources. Groundwater in rural settlements near enterprises is in most cases the only source of water supply. The laboratory analysis of water samples from selected points in 2020 showed an excess of color, odor at 60 °C, turbidity, total iron in bores and wells. The detected elevations are due to the peculiarity of the geological structure (aquifer of Eocene sediments). The excess in the hydrogen index is almost 10 times from the surface water body, which can be taken as "conditionally natural" (background) with further study of the specific impact of the complex on the environment. The main indicators that may indicate direct contamination of the pig complex, such as nitrates, nitrites, ammonium nitrogen and microbiological studies, do not exceed the normalized values, set for drinking water. In this case, the specific indicators are within normal limits. Petroleum products were not detected in the studied samples
Productivity and viral diseases of seed potatoes depending on the period of potato desiccation
Authors: Vushnevska Olga , Dmytrenko Volodymyr , Zakharchuk Nataliia , Oliinyk Tetiana 
Published: October 2021

The aim of the research was to determine the crop productivity, yield of tubers of seed fraction and infection of basic potato seeds with viral infection depending on the period of potato desiccation, application of mineral oil Sunspray, the number and species of winged aphids in the Polissia region of Ukraine. The study was conducted in the prebasic seed production nursery garden of the Institute for Potato Research, NAAS under the conditions of spatial isolation from the main sources and vectors of viral infections of potatoes, located in Nemishaieve, Borodiаnka distr., Kyiv region in the southern part of the Polissia region of Ukraine. The subject of the research is pre-basic and basic seed material of potatoes of mid ripening varieties Myroslava, Predslava, Alians. On average for 2018-2020 years of studies, the highest seed yield was obtained by potato desiccation 10 days after flowering of potatoes - 82.4-85.3 %. However, the level of total and seed yields was low. The efficiency of seed potato production increased with the haulm removal after 20 days - with the total yield depending on the variety 20.6-30.0 t/ha, the yield of seed tubers was in the range of 20.6-22.9 t/ha with the seed content in the crop structure - 71.0-76.3 %. Late haulm removal – on 30th and 40th days after potatoes flowering caused an increase in the yield of tubers of non-standard fraction, with desiccation on 30th day, the seed content in the crop decreased by 61.1-66.0 %, and with desiccation on 40th – by 54-59.8 %. Thus, during the early haulm removal, part of the crop was lost, which during haulm removal in the late stages consisted of large tubers. It has been found out, that potato plants, where the haulm removal during 2018, 2019 was carried out within 10 days after flowering, which was 4.0 % (9.0 % for the check) for the Myroslav potato variety, 3.0 % (10.0 % for the check) for the Predslava potato variety and 4.0 % (9.0 % for the check) for the Alians potato variety were the least infected with PVM. The level of PVM infection when removing the haulm on the 10th day after flowering with the application of Sunspray mineral oil at a rate of 6.0 l/ha decreased on average for the three varieties by 1.5–2.5 %. The best option to preserve the quality characteristics of seed potatoes was to desiccate the potato haulm on 20th day after flowering of potato varieties Myroslava, Predslava and Alians and the application of mineral oil Sunspray - 6.0 l / ha. The yield was 28.8-30.0 t/ha, seed fraction 20.6-22.9, seed yield - 71.0-76.3 %, viral PVM infection was 2.0 3.0 %
Effect of the improved protein-mineral additive on structural-mechanical characteristics of minced meat
Authors: Leshchenko Kateryna , Serik Maksym , Pyvovarov Yevgen , Zahorulko Andrii , Zagorulko Aleksey 
Published: October 2021

The results of research on the effect of protein-mineral improved additive (PMIA) on the rheological parameters of minced meat, which can be used for manufacturing culinary products, including chopped semi-finished products of a high degree of readiness, are presented. It has been proven, that the additive can be used both as an ingredient, enriching calcium-digestible compounds and to improve a number of technological properties of minced meat, in particular after freezing, storage and thawing. The aim of the study was to determine the dependences of changes in the structural and mechanical characteristics of minced meat after the addition of PMIA and subsequent freezing to a temperature of –16…–18 °C and storage for 20 days.
It has been found, that the addition of up to 7 % of PMIA leads to a marked increase in the conditionally instantaneous modulus of elasticity and highly elastic modulus in 4.4 times for minced beef and 2.7 and 4.4 times for chicken, respectively. It has been established, that the best stabilization of these indicators after freezing occurs at the content of PMIA at the level of 2…5 %. Studies of plastic viscosity and adhesion have shown that the use of up to 7 % of PMIA leads to an increase of 11…20 % and 26…64 %, respectively. After freezing, the plastic viscosity and adhesion of minced beef in the control decreased by 22.0 and 52 %, respectively, minced chicken – by 23.4 and 40.9 %. In the samples with a content of 7 % of PMIA, the decrease in plastic viscosity and adhesion is 7.2 and 4.4 % in minced beef and in chicken – 5.9 and 3.1 % respectively.
It has been proven, that the use of PMIA in the amount of up to 7 % in the technology of minced meat production minimizes the negative destructive effect of low temperatures on the structural and mechanical characteristics of the finished product. Thus, it is expedient to use up to 7.0 % of the improved protein-mineral additive in the composition of minced meat to enrich the finished product with digestible calcium compounds and improve their structural and mechanical characteristics, in particular after freezing and storage
Forecasting the Territorial-Spatial Development of the System of Children’s Medical Complexes in Ukraine
Authors: BULAKH Irina 
Published: October 2021

Abstract
The forecast development prediction in time-space of the urban system of pediatric treatment facilities of Ukraine is given at the national-territorial level, based on three complementary information sources for the future: the author's structure of the urban system of healthcare, its components, and promising types of medical institutions; retrospective analysis and patterns of organization and development of the urban system of medical institutions in the leading countries of the world, which indicate the general direction of extrapolation of systems; projected population of Ukraine (optimistic, optimal and pessimistic options), which are obtained through many years of statistical research. The paper presents the results of modeling, which demonstrate the forecast scenarios for the system development of pediatric treatment facilities at the national level of the urban network of primary care facilities and hospital networks. The model’s scenarios contain time prospects of the forecast for 2030, 2040, 2050, 2060, and 2100. The probable non-linear deviations characteristic of the space-time development of the open system and many internal and external probable points of system bifurcations are considered. The research should be challenging and effective for international scientists who study the range of issues of the urban and spatial development of urban systems, their forecast models, and deployment scenarios. The study is also valuable for countries that face the problems of stable depopulation, have an ineffective and cumbersome healthcare system, and are in the process of looking for ways to reform the medical system in an urban planning context.
Contextuality is a Condition for Preserving the Uniqueness of a Historical City
Authors: LESHCHENKO Nellia 
Published: October 2021

Abstract
The definition of contextuality is given. The material and non-material components of the urban context are highlighted. The factors of influence on its formation and development have been determined. It was found that the formed certain architectural and urban planning context, which determines the unrepeatability of the city, is the result of the total impact on the internal features and properties of existing buildings and open urban space the external natural, historical-cultural, historical-political, national, religious and socio-economic, and also information technology and legal factors throughout the entire period of the city’s existence. The parameters are highlighted as defining characteristics of the “place”, according to which it is proposed to evaluate the “sustainability” of the historically established architectural and urban planning context. It is assessed as the preservation and harmonious development of these defining characteristics in eddition with modern new elements and connections. It is important for possible restoration-reconstructive transformations in order to preserve context’s uniqueness, ensure sustainable continuity and increase attractiveness through the activation of existing historical accumulations and their addition with modern new ones.
Eco-Design and its Tools - Attempted use in the Military Industry
Authors: MROZEK Adrian 
Published: October 2021

Abstract
The development of military technology in recent years has made tremendous progress. However, some of these technologies have a direct impact on environmental degradation. This makes it necessary to introduce new solutions and technologies in the field of environmental protection. The paper provides a literature review on issues such as eco-design and its tools, life cycle assessment as well as attempted use of them in the defence sector. The environmental regulations and standards ensuring the quality of defence product have been described. In the military industry whose priorities are primarily related to defense the classic approach to design and its tools focused its attention on safety, functionality, ergonomics, costs, strength and technical parameters, instead of environmental problems. In fact militarism has huge impact on the climate because of giant greenhouse gas emissions, the main problem of the Armed Forces is the increased carbon footprint emissions which should be reduce of therefore case studies of eco-design and its tools, commercial software tools for carbon footprint calculation and life cycle assessment are described. The research is co-financed under the Program of the Ministry of Science and Higher Education “Implementation Doctorate”.
Road Obstacle Object Detection Based on Improved YOLO V4
Authors: Zuo Xiao , Yu Jun , Xian Tong , Hu Yuzhe , Hu Zhiyi 
Published: October 2021

Abstract
In recent years, as one of the important technical tasks in the field of deep learning, object detection has broad prospects and applications in the field of road obstacle detection. However, in the real driving scene, there are many obstacles, serious occlusion, overlap and other problems, so that the existing obstacle detection algorithm can not effectively detect the obstacles on the road, so it can not guarantee the driving safety. In order to solve the above problems, this paper improves on the basis of Yolo V4 algorithm. Firstly, kmeans + + clustering is used to generate a priori box suitable for the data set to enhance the scale adaptability; Then, the ciou is used as the loss function of coordinate prediction to evaluate the coincidence degree of prediction frame and truth value frame more reasonably. Finally, a suitable target detection data set is constructed by preprocessing the public data set cityccaps. The experimental results show that the improved algorithm can achieve more than 90% accuracy for obstacles with large number of targets in the training set. Compared with the original Yolo V4, the average detection accuracy of the improved algorithm is improved by 2.03%.
One Way Travel Restriction Device
Authors: Zihang Hu , Guolong Liu , Yuan Mi 
Published: October 2021

Abstract
A one-way travel restriction device is proposed. This device can be used on the road to limit the one-way traffic of vehicles, avoid retrograde, private car parking space will be occupied sometimes, and the unsafe factors such as occupying the road at the construction site or road in dangerous state. At present, the one-way traffic restriction on the road mainly depends on the use of traffic police, which is not only inefficient, but also wastes a lot of human resources. One way travel restriction device can solve the above problems. The one-way travel restriction device has complete functions and works efficiently, quickly and conveniently, which conforms to the requirements of the times. So how to meet the needs of modern people in the development of intelligence, mechanical and electronic information integration of the control operation structure provides the possibility of practicality, has a very large development value and broad market prospects.
Hybrid Quantum Mechanics/Molecular Mechanics (QM/MM) Simulation:
A Tool for Structure-Based Drug Design and Discovery
Authors: Kulkarni Prajakta U. , Shah Harshil , Vyas Vivek K. 
Published: October 2021

Abstract:
Quantum Mechanics (QM) is the physics-based theory that explains the physical properties
of nature at the level of atoms and sub-atoms. Molecular mechanics (MM) construct molecular systems
through the use of classical mechanics. So, when combined, hybrid quantum mechanics and molecular
mechanics (QM/MM) can act as computer-based methods that can be used to calculate the
structure and property data of molecular structures. Hybrid QM/MM combines the strengths of QM
with accuracy and MM with speed. QM/MM simulation can also be applied for the study of chemical
processes in solutions, as well as in the proteins, and has a great scope in structure-based drug design
(SBDD) and discovery. Hybrid QM/MM can also be applied to HTS to derive QSAR models. Due to
the availability of many protein crystal structures, it has a great role in computational chemistry, especially
in structure- and fragment-based drug design. Fused QM/MM simulations have been developed
as a widespread method to explore chemical reactions in condensed phases. In QM/MM simulations,
the quantum chemistry theory is used to treat the space in which the chemical reactions occur; however,
the rest is defined through the molecular mechanics force field (MMFF). In this review, we have
extensively reviewed recent literature pertaining to the use and applications of hybrid QM/MM simulations
for ligand and structure-based computational methods for the design and discovery of therapeutic
agents.
Targeting Histidine for Developing a New Generation of Covalent Enzyme
Inhibitors
Authors: Poirier Donald 
Published: October 2021

:
Despite the significant number of irreversible inhibitors developed over the years, strong
prejudices remain for this type of therapeutic molecule, particularly in the area of drug development.
New generations of covalent targeted inhibitors are, however, in development, and interest is increasingly
growing. In fact, the new generation of covalent inhibitors has a weakly reactive species (warhead)
that is able, in a particular context, to selectively form a chemical bond with a given amino acid
residue, which can be irreversible or reversible. In addition to new selective warheads, new amino acids
are also targeted. In the following text, we will focus on covalent targeted inhibitors that selectively alkylate
histidine.
Safety of Intravenous Thrombolysis and Mechanical Thrombectomy in
Bilateral Posterior Cerebral Artery Territory Infarction
Authors: Acampa Maurizio , Guideri Francesca , Bracco Sandra , Tassi Rossana , Domenichelli Carlo , Lazzerini Pietro Enea , Cioni Samuele , Martini Giuseppe 
Published: October 2021

Background:
Acute bilateral blindness is an uncommon phenomenon that requires immediate
diagnosis and action. The emergent evaluation should concentrate on an early distinction
between ocular, cortical, and psychogenic etiologies.

Objective:
To present a case of cortical blindness without anosognosia due to the embolic occlusion
of both posterior cerebral arteries (PCAs) and treated by intravenous and mechanical thrombolysis.

Case Report:
A 67-year-old woman was admitted to the Stroke Unit due to cortical blindness without
anosognosia. At the admission to the hospital, an emergent computed tomography scan of the
brain ruled out intracranial acute hemorrhage and showed subtle changes consistent with hyperacute
ischemia of the left occipital cortex, while a CT angiography demonstrated the occlusion of
the P3 segment of both right and left posterior cerebral arteries. The patient was treated with combined
thrombolysis (intravenous and mechanical thrombolysis), obtaining complete revascularization
and a significant clinical improvement.

Conclusion:
Even if there is no randomized controlled trial to compare the effectiveness and safety
of mechanical thrombectomy (MT) to intravenous thrombolysis in patients with posterior circulation
occlusion, the good outcome of this case encourages combined stroke treatments in posterior
circulation stroke, even in case of mild but disabling neurological deficits.
Tremor and Rigidity in Patients with Parkinson’s Disease: Emphasis on
Epidemiology, Pathophysiology and Contributing Factors
Authors: Kumar Shivam , Goyal Lav , Singh Shamsher 
Published: October 2021

:
Parkinson's disease (PD) is the second most prominent neurodegenerative movement disorder
after Alzheimer’s disease, involving 2-3% of the population aged above 65 years. This is
mainly triggered by the depletion of dopaminergic neurons located in substantia nigra pars compacta
(SNpc) in the region of basal ganglia. At present, diagnosis for symptoms of PD is clinical, contextual,
unspecified and therapeutically incomprehensive. Analysis of various causes of PD is essential
for an accurate examination of the disease. Among the different causes, such as tremors and
rigidity, unresponsiveness to the current treatment approach contributes to mortality. In the present
review article, we describe various key factors of pathogenesis and physiology associated with tremors
and rigidity necessary for the treatment of PI (postural instability) in patients with PD. Additionally,
several reports showing early tremor and rigidity causes, particularly age, cortex lesions,
basal ganglia lesions, genetic abnormalities, weakened reflexes, nutrition, fear of fall, and altered
biomechanics, have been explored. By summarizing the factors that contribute to the disease, histopathological
studies can assess rigidity and tremor in PD. With a clear understanding of the contributing
factors, various prospective studies can be done to assess the incidence of rigidity and tremors.