bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical Vapor Deposition Growth of Ternary Cu3PS4 Nanowires for Polarization‐Sensitive Photodetection
Authors: Kong Denan , Dong Weikang , Yu Hongbin , Zhao Chunyu , Zhao Yang , Yang Yang , Fu Longyi , Jia Lin , Wang Ping , Liu Jijian , Zheng Shoujun , Xiong Yan , Liu Ruibin , Zhou Yao , Zhou Jiadong 
Published: December 2024

AbstractLow‐dimensional ternary materials with low‐symmetry structure have emerged as promising candidates for constructing polarization‐sensitive photodetectors. However, the photodetection applications of ternary materials remain challenging due to the limited varieties and the uncontrollable preparation. Herein, ternary Cu3PS4 nanowires with tunable thickness are successfully synthesized via chemical vapor deposition method. The grown Cu3PS4 nanowires present excellent structural anisotropy and strong in‐plane second‐order nonlinear optical anisotropy, as evidenced by angle‐resolved polarized Raman spectra and second harmonic generation measurements. Impressively, Cu3PS4‐based photodetector demonstrates a responsivity of 8.8 mAW−1, detectivity of 5.01 × 109 Jones, and photoresponse speeds with rise (decay) time of 1.5 (3.5) ms. Interestingly, the photodetector achieves polarization‐sensitivity photoresponse with an anisotropic ratio of 1.3 at 520 nm based on its inherent structural anisotropy and geometrical shapes. This work broadens the scope of synthesis strategy for various low‐dimensional ternary metal chalcohalide semiconductors and provides great opportunities for designing high‐performance and multifunctional optoelectronic devices.
Enhanced Circularly Polarized Luminescence Modulation Using Dichroic Conjugated Polymer in Cholesteric Liquid Crystals
Authors: Chen Yihan , Li Lulu , Yao Kun , Fu Chunya , Li Yang , Cheng Yixiang 
Published: December 2024

AbstractNegative dichroic dyes are crucial for enhancing the brightness of liquid crystal displays (LCDs) and modulating circularly polarized luminescence (CPL) in cholesteric liquid crystals (CLCs) through supramolecular co‐assembly. However, the majority of fluorescent molecules exhibit positive dichroism, and there is a limited understanding of designing negative dichroic molecules. In this paper, a novel design principle is proposed to construct the negative dichroic polymer by introducing through space charge transfer (TSCT) side chain structure to the polymer backbone. Specifically, two conjugated polymers (P1, P2) are synthesized using the Suzuki coupling reaction of two donor‐acceptor (D‐A) type monomers (V‐type M1 and I‐type M2) with fluorenyl monomer. P1 exhibits negative dichroism, and its orientational order parameter (SF) is up to SFP1 = –0.18. On the contrary, P2 is positive dichroism (SFP2 = + 0.27). This variation arises from the differing orientations of the rigidly functional side chains (SFM1 = + 0.07; SFM2 = + 0.31), which affect the alignment (parallel or perpendicular) of the polymer backbone toward CLCs molecules. This phenomenon facilitates controllable dichroism and precisely modulates the handedness of CPL signals, thereby facilitating the successful implementation of multidimensional information encryption systems in CLCs.
Perovskite‐Inspired Cs₂AgBi₂I₉: A Promising Photovoltaic Absorber for Diverse Indoor Environments
Authors: Krishnaiah Mokurala , Singh Kuntal , Monga Sanchi , Tripathi Akash , Karmakar Sougata , Kumar Ramesh , Tyrpenou Christos , Volonakis George , Manna Debjit , Mäkinen Paavo , Adarsh K. V. , Bhattacharya Saswata , Grandhi G. Krishnamurthy , Rao K. D. M. , Vivo Paola 
Published: December 2024

AbstractIndoor photovoltaics (IPVs) using low‐toxicity bismuth‐based perovskite‐inspired materials (PIMs) can potentially power the growing number of Internet of Things devices sustainably. However, modest indoor power conversion efficiency (PCE) values are reported due to intrinsic limitations of PIMs, particularly regarding charge carrier separation and transport. Herein, polycrystalline Cs₂AgBi₂I₉ thin films are developed with high phase purity and study their fundamental structural and photophysical properties. The comprehensive experimental and computational study reveals unique optoelectronic properties of Cs₂AgBi₂I₉ compared to other bismuth‐containing PIMs, including weak electron‐phonon coupling and low exciton binding energy (40 meV). This study also demonstrates the feasibility of large and highly mobile polaron formation in Cs₂AgBi₂I₉, supported by the observation of a phonon bottleneck and a delayed hot carrier lifetime of over 200 ps, which suggests enhanced defect tolerance and transport properties. Motivated by the suitable bandgap of this absorber (1.78 eV), the first Cs₂AgBi₂I₉‐based IPVs are developed, achieving a PCE of ≈8% at 1000 lux. Notably, the devices maintain high performance across various indoor environments with white LED color temperatures ranging from 2700 to 6500 K. The calculated theoretical PCE limit of >40% and the promising operational stability position Cs₂AgBi₂I₉ as one of the most intriguing candidates for sustainable IPVs.
Optimal Cerebral Blood Flow Thresholds for Ischemic Core Estimation Using Computed Tomography Perfusion and Diffusion‐Weighted Imaging
Authors: Kim Nakhoon , Ryu Wi‐Sun , Ha Sue Young , Kim Jun Yup , Kang Jihoon , Baik Sung Hyun , Jung Cheolkyu , Han Moon‐Ku , Bae Hee‐Joon , Lin Longting , Parsons Mark , Kim Beom Joon 
Published: December 2024

ObjectiveComputed tomography perfusion (CTP) imaging is crucial in quantifying cerebral blood flow (CBF) and thereby making an endovascular treatment (EVT) after large vessel occlusion. However, CTP is prone to overestimating the ischemic core. We sought to delineate the optimal regional CBF (rCBF) thresholds of pre‐EVT CTP.MethodsWe collected acute ischemic stroke patients due to large vessel occlusion who achieved successful recanalization with baseline CTP, immediate post‐EVT diffusion‐weighted image (DWI) within 3 hours, and delayed post‐EVT DWI between 24 and 196 hours. Core volumes estimated by CTP at various rCBF thresholds were validated against immediate and delayed DWI lesion volumes.ResultsA total of 175 acute large vessel occlusion patients were included. Baseline CTP was taken in a median of 24 minutes (interquartile range [IQR] 21–31 minutes) after arrival; after the CTP, groin puncture in a median of 37 minutes (IQR 28–52 minutes), immediate post‐EVT DWI scans in a median of 1.6 hours (IQR 0.8–2.1 hours), and delayed DWI scans in a median of 89 hours (IQR 69–106 hours). The correlations between the rCBF thresholds were the best at rCBF <22% for immediate DWI (0.64; 95% CI 0.55–0.73) and at rCBF <30% for delayed DWI (0.69; 95% CI 0.61–0.76). The interval between CTP and recanalization was inversely correlated with the overestimation of ischemic core volume compared with the subsequent DWI.InterpretationOptimal rCBF thresholds for estimating ischemic core using CTP depend significantly on the timing of DWI post‐EVT and CTP to recanalization delay. The optimal rCBF thresholds for ischemic core estimation may vary depending on the clinical setting. ANN NEUROL 2024
Stellar Physics and General Relativity
Authors: Yokoyama Shuichi 
Published: December 2024

ABSTRACTThe general theory of relativity is currently established as the most precise theory of gravity supported by observations, and its application is diverse ranging from astronomy to cosmology, while its application to astrophysics has been restricted only to compact stars due to the assumption that the Newtonian approximation is sufficient for celestial bodies with medium density such as the sun. Surprisingly, the recent research of the author has implied that this long‐held assumption is not valid, and that nonperturbative effects significantly change relevant results obtained by Newtonian gravity. In particular, local physical quantities inside the sun are newly predicted to exhibit power law differently from the so‐called standard solar model. This surprising result is reviewed including brief discussion of physics behind the discrepancy and a little new application.
PRKAA2 Promotes Tumor Growth and Inhibits Ferroptosis through SLC7A11/GSH/GPX4 Pathway in Non‐Small Cell Lung Cancer
Authors: Wei Zhiqiang , Zhou Zhilian , Zhang Yu , Wang Jie , Huang Ke , Ding Yuanyu , Sun Yingming , Gu Mingming , Kong Xiangang , Xi Erping , Zeng Shaoshan 
Published: December 2024

ABSTRACTNon‐small cell lung cancer (NSCLC) is the most pervasive sort of lung cancer with deadly outcome. According to recent studies, a number of neoplastic disorders and ferroptosis are intimately connected. This study aims to identify the role of key ferroptosis‐related gene (protein kinase AMP‐activated catalytic subunit alpha 2, PRKAA2) and explore new directions for the diagnosis and treatment of NSCLC. The PRKAA2 expression and its influence on survival were analyzed in multiple public databases (TCGA, TIMER2.0, and GEPIA). And PRKAA2 mRNA level in NSCLC cells were examined by qRT‐PCR. Silencing of PRKAA2 (sh‐PRKAA2) were used to cell transfection. CCK‐8, EdU, and flow cytometry assays were used to measure cell proliferation and apoptosis. The protein levels of ferroptosis markers (SLC7A11, GPX4, and NRF2) were determined by western blotting. Meanwhile, the related ferroptosis analysis, such as malondialdehyde (MDA) and glutathione (GSH), reactive oxygen species (ROS), iron, and Fe2+ levels were also detected in the transfected cells. Moreover, the relationship between PRKAA2 expression and SLC7A11 was analyzed. NSCLC xenograft mouse models were used for in vivo verification of the PRKAA2 function. Here, our data revealed that PRKAA2 was upregulated in NSCLC cells. Additionally, PRKAA2 strengthened cell proliferation and attenuated apoptosis and ferroptosis of NSCLC cells. The depletion of PRKAA2 enhanced the erastin‐induced inhibition effect on cell growth, and notably increased the levels of MDA, ROS, iron, and Fe2+, while decreased GSH level in NSCLC cells. In the mechanism exploration, we discovered that PRKAA2 could activate the SLC7A11/GSH/GPx4 antioxidant pathway. The rescue experiments showed that SLC7A11 abrogated the inhibitive impacts of PRKAA2 repression on cellular proliferation, cell apoptosis, and ferroptosis in NSCLC. Besides, animal experiments proved that PRKAA2 enhanced NSCLC tumor growth in vivo. The results discovered that PRKAA2 accelerated the malignant progression, diminished apoptosis and ferroptosis in NSCLC through SLC7A11/GSH/GPX4 pathway. This study provide a novel target in the application of PRKAA2 for NSCLC treatment.
New Horizons in Myotonic Dystrophy Type 1: Cellular Senescence as a Therapeutic Target
Authors: Légaré Cécilia , Berglund J. Andrew , Duchesne Elise , Dumont Nicolas A. 
Published: December 2024

ABSTRACTMyotonic dystrophy type 1 (DM1) is considered a progeroid disease (i.e., causing premature aging). This hypervariable disease affects multiple systems, such as the musculoskeletal, central nervous, gastrointestinal, and others. Despite advances in understanding the underlying pathogenic mechanism of DM1, numerous gaps persist in our understanding, hindering elucidation of the heterogeneity and severity of its symptoms. Accumulating evidence indicates that the toxic intracellular RNA accumulation associated with DM1 triggers cellular senescence. These cells are in a state of irreversible cell cycle arrest and secrete a cocktail of cytokines, referred to as a senescence‐associated secretory phenotype (SASP), that can have harmful effects on neighboring cells and more broadly. We hypothesize that cellular senescence contributes to the pathophysiology of DM1, and clearance of senescent cells is a promising therapeutic approach for DM1. We will discuss the therapeutic potential of different senotherapeutic drugs, especially senolytics that eliminate senescent cells, and senomorphics that reduce SASP expression.
Cataluminescence Sensor Based on Halloysite Nanotubes/MgO Nanocomposite for Rapid Detection of Ether
Authors: Liu Yilu , Shi Zhaoxia , Zhang Yintang , Li Zhaohui , Xu Maotian 
Published: December 2024

ABSTRACTMgO surface makes it easy to introduce a certain amount of oxygen vacancy and can enhance catalytic reaction activity. Besides, as a silicoaluminate mineral material, halloysite nanotube (HNT) has a unique tubular structure. In this paper, the HNTs@MgO composite was successfully synthesized based on natural clay material HNTs as a carrier, and the CTL sensor based on HNTs@MgO was successfully developed for the rapid determination of ether in air. The HNTs@MgO material was characterized by a series of means such as SEM, XPS, and XRD, which clearly confirmed that MgO successfully combined with HNTs. And the sensor showed good sensitivity and selectivity, with a good linear relationship between CTL intensity and ether concentration in the range of 0.5–190.0 mg/L (R2 = 0.9942), and the limit of detection (LOD) was 0.18 mg/L (S/N = 3). The RSD values of the results of 11 consecutive measurements by the same sensor and 7 days of consecutive measurements were 1.96% (n = 11) and 3.42% (n = 7), showing good repeatability and reproducibility. At last, the CTL sensor was used to detect air samples, the recoveries ranged from 91.6% to 109.6%. Thus, it was concluded that HNTs@MgO composite is a cost‐effective and promising material with potential application in atmospheric detection.
Sensitivity of bulk electrical impedance spectroscopy (bio‐capacitance) probes to cell and culture properties: Study on CHO cell cultures
Authors: Salimi Elham , Absalan Sara , Robitaille Julien , Montes Johnny , Butler Michael , Thomson Douglas , Bridges Greg 
Published: December 2024

AbstractBulk electrical impedance spectroscopy (bio‐capacitance) probes, hold significant promise for real‐time cell monitoring in bioprocesses. Focusing on Chinese hamster ovary (CHO) cells, we present a sensitivity analysis framework to assess the impact of cell and culture properties on the complex permittivity spectrum, εmix, and its associated parameters, permittivity increment, Δε, critical frequency, fc, and Cole‐Cole parameter, α, measured by bio‐capacitance probes. Our sensitivity analysis showed that Δε is highly sensitive to cell size and concentration, making it suitable for estimating biovolume during the exponential growth phase, whereas fc provides information about cumulative changes in cell size, membrane permittivity, and cytoplasm conductivity during the transition to death phase. The analysis indicated that specific information about cell membrane permittivity or internal conductivity cannot be extracted from εmix spectrum. Based on the sensitivity analysis, we proposed two alternative parameters for monitoring cells in bioprocesses: Δε1 MHz and Δε1 MHz/Δε0.3 MHz, using measurements at 300 kHz, 1 MHz, and 10 MHz. Δε1 MHz is suitable for estimating viable cell density during the exponential growth phase due to its lower sensitivity to cell size. Δε1 MHz/Δε0.3 MHz can replace fc due to similar sensitivities to cell size and dielectric properties. These frequencies are within most bio‐capacitance probes' optimal operation range, eliminating the need for low‐frequency electrode polarization and high‐frequency stray capacitances corrections. Experimental measurements on CHO cells confirmed the results of sensitivity analysis.
Orchestrated desaturation reprogramming from stearoyl‐CoA desaturase to fatty acid desaturase 2 in cancer epithelial‐mesenchymal transition and metastasis
Authors: Chen Zhicong , Gong Yanqing , Chen Fukai , Lee Hyeon Jeong , Qian Jinqin , Zhao Jing , Zhang Wenpeng , Li Yamin , Zhou Yihui , Xu Qiaobing , Xia Yu , Zhou Liqun , Cheng Ji‐Xin 
Published: December 2024

AbstractBackgroundAdaptative desaturation in fatty acid (FA) is an emerging hallmark of cancer metabolic plasticity. Desaturases such as stearoyl‐CoA desaturase (SCD) and fatty acid desaturase 2 (FADS2) have been implicated in multiple cancers, and their dominant and compensatory effects have recently been highlighted. However, how tumors initiate and sustain their self‐sufficient FA desaturation to maintain phenotypic transition remains elusive. This study aimed to explore the molecular orchestration of SCD and FADS2 and their specific reprogramming mechanisms in response to cancer progression.MethodsThe potential interactions between SCD and FADS2 were explored by bioinformatics analyses across multiple cancer cohorts, which guided subsequent functional and mechanistic investigations. The expression levels of desaturases were investigated with online datasets and validated in both cancer tissues and cell lines. Specific desaturation activities were characterized through various isomer‐resolved lipidomics methods and sensitivity assays using desaturase inhibitors. In‐situ lipid profiling was conducted using multiplex stimulated Raman scattering imaging. Functional assays were performed both in vitro and in vivo, with RNA‐sequencing employed for the mechanism verification.ResultsAfter integration of the RNA‐protein‐metabolite levels, the data revealed that a reprogramming from SCD‐dependent to FADS2‐dependent desaturation was linked to cancer epithelial‐mesenchymal transition (EMT) and progression in both patients and cell lines. FADS2 overexpression and SCD suppression concurrently maintained EMT plasticity. A FADS2/β‐catenin self‐reinforcing feedback loop facilitated the degree of lipid unsaturation, membrane fluidity, metastatic potential and EMT signaling. Moreover, SCD inhibition triggered a lethal apoptosis but boosted survival plasticity by inducing EMT and enhancing FA uptake via adenosine monophosphate‐activated protein kinase activation. Notably, this desaturation reprogramming increased transforming growth factor‐β2, effectively sustaining aggressive phenotypes and metabolic plasticity during EMT.ConclusionsThese findings revealed a metabolic reprogramming from SCD‐dependent to FADS2‐dependent desaturation during cancer EMT and progression, which concurrently supports EMT plasticity. Targeting desaturation reprogramming represents a potential vulnerability for cancer metabolic therapy.
Synthesis and Characterization of Silver and Zinc Nanoparticles From Vitex altissima: Comparative Analysis of Anti‐Oxidant, Anti‐Inflammatory, Antibacterial, and Anti‐Biofilm Activities
Authors: Lekkala VijayaDurga V. V. , Sirigireddy Bharathi , Reddy Madhava C. , Lomada Dakshayani 
Published: December 2024

ABSTRACTMetal nanoparticles have attained much popularity due to their low toxicity, economic feasibility, and eco‐friendly nature. The present study focuses on the synthesis of silver and zinc nanoparticles from Vitex altissima leaf extract, further characterized by UV/Vis spectral analysis, Powder‐x‐ray diffraction (XRD), FE‐SEM, Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), and zeta potential. Synthesized silver and zinc nanoparticles were screened for antioxidant, anti‐inflammatory, antibacterial, and anti‐biofilm activities. AgNPs exhibited moderate antioxidant activities compared to ZnNPs, which were studied using 2,2‐diphenyl‐1‐picrylhydrazyl radical (DPPH) and ABTS assays. The anti‐inflammatory effect was assessed using membrane stabilization and human red blood cell methods. Furthermore, both types of nanoparticles, AgNPs and ZnNPs, exhibited anti‐biofilm activity against four MDR bacterial strains: Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Synthesized nanoparticles show antibacterial activity. Our data suggest that silver nanoparticles exhibited moderate activity compared to ZnNPs. These nanoparticles could act as potential antioxidant, anti‐inflammatory, and antibacterial agents.
BIM tunneling documentation in Rohbaustollen Angath
Authors: Senekovic Jaka , Gaudart Dario , Heil Mag. Frédéric , Arnold Roland , Krasa Johannes 
Published: December 2024

AbstractSince 2023, Austrian Federal Railways (ÖBB), with BEMO‐ÖSTU STETTIN, has been constructing the 2.6 km raw construction tunnel Angath (Rohbaustollen Angath) along the Angerberg. It will support geological investigations, logistics for the future main railway tunnel Angerberg, and act as a rescue tunnel, ensuring safety. The project includes a pre‐cut, tunnel excavation, and a 110‐meter section of the main railway tunnel, with turning niches and cross adits. Building information modeling (BIM) is used for design, tendering, control, and documentation. The integrated project delivery (IPD) model ensures shared responsibility for risks and costs. BIM optimizes data flow and transparency, with tunneling documentation collected on‐site, verified in ÖBB's Common Data Environment (MSP), and used for parametric modeling. Cost and progress monitoring occur via software RIB iTWO (Version 2023, 2023). Project documentation and the linking of the documentation into a 3D BIM model of a tunnel enables early detection of deviations and appropriate action to be taken, with transparency and traceability being critical to the success of the IPD project.
Oil Spill Response: Existing Technologies, Prospects and Perspectives
Authors: Jayarathna Methmini Dilhara , Rajapaksha Anushka Upamali , Samarasekara Sameera , Vithanage Meththika 
Published: December 2024

ABSTRACTThe growth of the economy and technological advancement has led to an increased demand for energy and the transportation of raw materials for the production of fuels, chemicals, and petroleum products. However, this increased activity has also resulted in an elevated risk of oil‐related disasters, which can have devastating consequences for the environment and local communities. More than 1700 oil spills have occurred, including severe spills such as the Deepwater Horizon spill in 2010, which released 134 million gallons. However, technological developments and restrictions have resulted in a significant reduction in spills. Oil spills happened in aquatic and terrestrial environments providing numerous impacts on wildlife and public health. Existing literature may have limited scope or depth; therefore, this review addresses the literature gap by discussing the strengths and limitations of current and emerging technologies for detecting, cleaning, and restoring oil‐contaminated marine and soil sites. Booms, skimmers, chemical agents (dispersants), and in situ burning are generally used for oil spill remediation. Other than conventional methods, numerous novel approaches including adsorbents (e.g., aerogels, carbon nanotubes, and other sorbents) and modified materials have been developed. For detection purposes, collaboration remote sensing and artificial intelligence are used as new emerging technologies. Modified oil adsorbents such as aerogels, sponges, and carbon nanotubes demonstrated high sorption capacity (> 100 g/g) for oil removal. Despite the challenges such as transport, high production cost, and toxicity, these emerging technologies have the potential to improve the effectiveness of oil spill remediation in the future. The materials with hybrid properties should be developed and more real‐scale tests should be tested to mitigate limitations in practical scenarios of developing novel sorbent modifications like nanoparticles and aerogels.