bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Student Pharmacists' Learning Through the Use of Pediatric Simulation
Authors: Eiland Lea S. , Chung Allison M. , Fowlin Julaine M. 
Published: November 2021

OBJECTIVE
The purpose of this study was to assess the effect of low-fidelity simulation on students' confidence, knowledge, and skills in pediatric physical assessments, and to compare students' interest ratings of topics and effectiveness of learning activities between students' who experienced simulation and those who did not.

METHODS
Within a pediatric elective, a vital signs and physical assessment activity was re-designed to incorporate a low-fidelity heart and breath sounds simulator. Students rated their confidence in completing 9 different physical assessment skills before and after the activity and assessment. Students' perspectives of the activity were also assessed. Course evaluation surveys were compared with prior course offerings (without simulation) to determine a change in students' interest ratings of the topic and effectiveness of learning activities. The Wilcoxon signed rank test, thematic analysis, and descriptive statistics were used to analyze outcomes.

RESULTS
All 106 second professional year students in the elective completed the pre- and post-simulation surveys and course evaluations for 3 offerings. Students' post-simulation average confidence scores increased statistically on all 9 skills compared with pre-simulation scores. All students agreed or strongly agreed “the lecture and simulation activity done in class helped me overcome challenges I had with learning the skill.” Students (98%) successfully demonstrated competency on the formal assessment. Compared with previous course offerings, students reported higher interest ratings in the topics and instruction effectiveness when simulation was incorporated into the activity.

CONCLUSIONS
Low-fidelity simulation is an effective teaching and learning approach to increase students' confidence, knowledge, and interest in pediatric vital signs and physical assessment.
Implementasi Konsep “Bound to Nature” pada Perancangan Interior Mangrove Edu-Tourism Centre di Surabaya
Authors: Laksono David Ardi , Thamrin Diana , Basuki Lucky 
Published: November 2021

Masalah yang menjadi latar belakang dari perancangan ini adalah masyarakat Surabaya kurang mengenal keberadaan ekosistem mangrove dan pengembangan potensi produk olahannya oleh UKM (Usaha Kecil Menengah) lokal di Surabaya. Disisi lain juga karena kurang terjangkaunya dan tidak memadainya wadah pendukung kegiatan tersebut. Tujuan dari Perancangan ini adalah menyediakan wadah alternatif untuk berkumpul dan mengenalkan kepada generasi millennial agar dapat memahami dan bereksperimen dengan potensi mangrove, melalui pendekatan edukatif, rekreatif, interaktif dan konten lokal, serta mensejahterakan masyarakat mangrove. Metode perancangan yang digunakan adalah metode Disney yang terdiri dari 4 tahap, yakni spectator view, dreamers view, realists view, dan critics view. Hasil perancangan adalah sebuah Mangrove Edu-Tourism Centre berkonsep Bound to Nature, dengan fasilitas ruang terbuka telaga, stal makanan, area informasi dan tunggu, galeri produk UKM, studio workshop, studio pembibitan, ruang staf, area santai, kubah konservatorial, dek atraktif, dan rumah teh. Penulis berharap melalui perancangan ini dapat memberi solusi sekaligus sebagai wadah komunitas global, dengan usaha mikro yang berefek makro untuk membantu mengelola dan menyelamatkan lingkungan mangrove di Surabaya.
Determining whether periodic health checkups have any preventive effect on deterioration in health among middle-aged adults: A hazards model analysis in Japan
Authors: Oshio Takashi , Tsutsumi Akizumi , Inoue Akiomi 
Published: November 2021

Abstract

Objectives
We aimed to examine the long-term impact of periodic health checkups (PHCs) on health outcomes among middle-aged adults.

Methods
We used longitudinal data from 29 770 individuals (15 399 men and 14 371 women) aged 50–59 years in the baseline year (2005), obtained from a population-based 14-wave survey. PHC participants were defined as those who underwent PHCs for the first three consecutive waves, and we investigated the onset of inpatient care for five types of non-communicable diseases (diabetes, heart disease, stroke, hypertension, and dyslipidemia) as well as poor self-rated health and problems in the activities of daily living in the subsequent 11 waves. Cox-proportional hazards models were used to estimate the impact of PHCs on health outcomes by employing the propensity score matching (PSM) method.

Results
Participation in PHCs was closely related to a respondent’s socioeconomic status and health behavior. After controlling for these factors by PSM, the hazard models showed that PHCs postponed the onset of inpatient care for hypertension (hazard ratio, 0.56; 95% confidence interval: 0.36–0.85) among men, but PHCs had no impact on any other health outcomes in men or women.

Conclusions
The preventive impact of PHCs on health deterioration is generally limited among middle-aged adults. Future studies should address policy measures to enhance the effectiveness of PHCs.
Interaction between sex and neurofilament light chain on brain structure and clinical severity in Huntington’s disease
Authors: Sampedro Frederic , Martinez‐Horta Saul , Pérez‐Pérez Jesús , Perez‐Gonzalez Rocio , Horta‐Barba Andrea , Campolongo Antonia , Aracil‐Bolaños Ignacio , Gomez‐Anson Beatriz , Kulisevsky Jaume 
Published: November 2021

AbstractFemale Huntington’s disease (HD) patients have consistently shown a faster clinical worsening than male, but the underlying mechanisms responsible for this observation remain unknown. Here, we describe how sex modifies the impact of neurodegeneration on brain atrophy and clinical severity in HD. Cerebrospinal fluid neurofilament light chain (NfL) levels were used as a biological measure of neurodegeneration, and brain atrophy was assessed by structural magnetic resonance imaging. We found that larger NfL values in women reflect higher brain atrophy and clinical severity than in men (p < 0.05 for an interaction model). This differential vulnerability could have important implications in clinical trials.
Complementary Dynamic Chemistries for Multifunctional Polymeric Materials
Authors: Zhang Borui , De Alwis Watuthanthrige Nethmi , Wanasinghe Shiwanka V. , Averick Saadyah , Konkolewicz Dominik 
Published: November 2021

AbstractDynamic materials (DMs) or dynamers have potential applications across a broad range of material science challenges. These applications include sustainable materials as a part of the circular plastics economy, advanced materials with tailored high stress properties and biomedical agents. DMs are comprised of polymers that crosslinked through reversible covalent and noncovalent linking groups. This group provides reversible bonds, which impart properties such as (re)healing, adaptability, toughness into a material. The nature of the linker dictates the dynamer's stability and dynamic properties, although for many applications one linker alone cannot give materials with complex multiresponsive functions. The combination of multiple dynamic linkers can introduce complementary functionalities into a single material. This combination of linkers enhances the collective material properties by matching their strengths and offsetting the weaknesses, or by selecting linkers for specific functions, such as one linker for rapid exchange and the other to respond to external stimuli. This contribution highlights the possibilities and unique features of materials containing multiple dynamic linkers, reviewing both fundamental discoveries of materials possessing multiple dynamic bonds and applications facilitated by the presence of multiple linking group chemistry.
Interfacial Charge Transfer between Silver Phosphate and W2N3 Induced by Nitrogen Vacancies Enhances Removal of β‐Lactam Antibiotics
Authors: Lin Yan , Yang Chunping , Niu Qiuya , Luo Shenglian 
Published: November 2021

AbstractConstructing heterojunctions has been demonstrated as an important approach to improve the catalytic performance of photocatalysts, but how to regulate the transfer and separation of photogenerated carriers at the interface is still a great challenge. Herein, W2N3‐NV, a two‐dimensional transition metal nitride containing nitrogen vacancies, is synthesized by a molten salt‐assisted atmosphere calcination method. A novel composite photocatalyst Ag3PO4@W2N3‐NV with good photocatalytic activity and photostability is prepared for the first time and applied to the efficient removal of β‐lactam antibiotics. The composite catalyst shows much superior photocatalytic degradation performance of penicillin and amoxicillin, and the apparent rate constant of which is 77.7 and 42.9 times than that of pure Ag3PO4, respectively. Experimental results and density functional theory calculations confirm that the presence of nitrogen vacancies can drive the formation of defects and dangling bonds on the W2N3‐NV surface, which make it easy to combine with Ag3PO4 and form new chemical bonds at the interface. The WO chemical bonds formed at the interface provide a fast transfer channel for the interfacial photogenerated charge, resulting in the boosted carriers transfer and separation ability of Ag3PO4@W2N3‐NV composite. This study provides a new strategy for the interface engineering of highly efficient heterogeneous photocatalysts.
Layered Superconductor Cu0.11TiSe2 as a High‐Stable K‐Cathode
Authors: Wu Lichen , Gu Mingyuan , Feng Yanhong , Chen Suhua , Fan Ling , Yu Xinzhi , Guo Kunkun , Zhou Jiang , Lu Bingan 
Published: November 2021

AbstractThe cathode material is one of the main restricting factors for the development of potassium‐ion batteries (PIBs). The poor conductivity, sluggish reaction kinetics, and unstable crystal structure of cathode materials have impeded their electrochemical performance. Here, controlled intercalation of TiSe2 with Cu is used to yield a layered superconductor Cu0.11TiSe2, which exhibits increased electrons and ions transfer rates and improved crystal structure stability. The insertion of Cu not only improves the electronic conductivity and reduces the diffusion barrier but also plays a role in crystal structure support, which further leads to a highly reversible charge and discharge process of Cu0.11TiSe2. The layered superconductor Cu0.11TiSe2 exhibits an excellent cycling performance with a capacity retention of 80% after 300 cycles at a current density of 20 mA g−1 and a superior rate capability with a capacity of 45 mAh g−1 at 1000 mA g−1 (≈8C). Furthermore, a full battery assembled with the Cu0.11TiSe2 cathode and graphite anode exhibits a high reversible capacity of 74 mAh g−1 at a current density of 20 mA g−1. This study provides a new path for developing the high‐performance cathode material of PIBs and other alkali metal‐ion batteries.
Anisotropic Foams via Frontal Polymerization
Authors: Alzate‐Sanchez Diego M. , Cencer Morgan M. , Rogalski Michael , Kersh Mariana E. , Sottos Nancy , Moore Jeffrey S. 
Published: November 2021

AbstractThe properties of foams, an important class of cellular solids, are most sensitive to the volume fraction and openness of its elementary compartments; size, shape, orientation, and the interconnectedness of the cells are other important design attributes. Control of these morphological traits would allow the tailored fabrication of useful materials. While approaches like ice templating have produced foams with elongated cells, there is a need for rapid, versatile, and energy‐efficient methods that also control the local order and macroscopic alignment of cellular elements. Here, a fast and convenient method is described to obtain anisotropic structural foams using frontal polymerization. Foams are fabricated by curing mixtures of dicyclopentadiene and a blowing agent via frontal ring‐opening metathesis polymerization (FROMP). The materials are characterized using microcomputed tomography (micro‐CT) and an image analysis protocol to quantify the morphological characteristics. The cellular structure, porosity, and hardness of the foams change with blowing agent, concentration, and resin viscosity. Moreover, a full factorial combination of variables is used to correlate each parameter with the structure of the obtained foams. The results demonstrate the controlled production of foams with specific morphologies using the simple and efficient method of frontal polymerization.
Strong π–π Stacking Stabilized Nanophotosensitizers: Improving Tumor Retention for Enhanced Therapy for Large Tumors in Mice
Authors: Xi Dongmei , Xu Ning , Xia Xiang , Shi Chao , Li Xiaojing , Wang Dongsheng , Long Saran , Fan Jiangli , Sun Wen , Peng Xiaojun 
Published: November 2021

AbstractConventional photosensitizers (PSs) often show poor tumor retention and are rapidly cleared from the bloodstream, which is one of the key hindrances to guarantee precise and efficient photodynamic therapy (PDT) in vivo. In this work, a photosensitizer assembly nanosystem that sharply enhances tumor retention up to ≈10 days is present. The PSs are synthesized by meso‐substituting anthracene onto a BODIPY scaffold (AN‐BDP), which then self‐assembles into stable nanoparticles (AN‐BDP NPs) with amphiphilic block copolymers due to the strong intermolecular π–π interaction of the anthracene. Additionally, the incorporated anthracene excites the PSs, producing singlet oxygen under red‐light irradiation. Although AN‐BDP NPs can completely suppress regular test size tumors (≈100 mm3) by one‐time radiation, only 12% tumor growth inhibition rate is observed in the case of large‐size tumors (≈350 mm3) under the same conditions. Due to the long‐time tumor retention, AN‐BDP NPs allow single‐dose injection and three‐time light treatments, resulting in an inhibition rate over 90%, much more efficient than single‐time radiation of conventional clinically used PSs including chlorin‐e6 (Ce6) and porphyrin with poor tumor retention. The results reveal the importance of long tumor retention time of PSs for efficient PDT, which can accelerate the clinical development of nanophotosensitizers.
Two Birds with One Stone: Interfacial Engineering of Multifunctional Janus Separator for Lithium–Sulfur Batteries
Authors: Li Yiju , Gao Tingting , Ni Dongyuan , Zhou Yin , Yousaf Muhammad , Guo Ziqi , Zhou Jinhui , Zhou Peng , Wang Qian , Guo Shaojun 
Published: November 2021

AbstractLi‐dendrite growth and unsatisfactory sulfur cathode performance are two core problems that restrict the practical applications of lithium–sulfur batteries (LSBs). Here, an all‐in‐one design concept for a Janus separator, enabled by the interfacial engineering strategy, is proposed to improve the performance of LSBs. At the interface of the anode/separator, the thin functionalized composite layer contains high‐elastic‐modulus and high‐thermal‐conductivity boron nitride nanosheets and oxygen‐group‐grafted cellulose nanofibers (BNNs@CNFs), by which the formation of “hot spots” can be effectively avoid, the Li‐ion flux homogenized, and dendrite growth suppressed. Meanwhile, at the interface between the separator and the cathode, the homogenously exposed single‐atom Ru on the surface of reduced graphene oxide (rGO@Ru SAs) can “trap” polysulfides and reduce the activation energy to boost their conversion kinetics. Consequently, the LSBs show a high capacity of 460 mAh g–1 at 5C and ultrastable cycling performance with an ultralow capacity decay rate of 0.046% per cycle over 800 cycles. To further demonstrate the practical prospect of the Janus separator, a lithium–sulfur pouch cell using the Janus separator delivers a cell‐level energy density of 310.2 Wh kg–1. This study provides a promising strategy to simultaneously tackle the challenges facing the Li anode and the sulfur cathode in LSBs.
Efficient Tandem Quantum‐Dot LEDs Enabled by An Inorganic Semiconductor‐Metal‐Dielectric Interconnecting Layer Stack
Authors: Wu Qianqian , Gong Xiwen , Zhao Dewei , Zhao Yong‐Biao , Cao Fan , Wang Haoran , Wang Sheng , Zhang Jianhua , Quintero‐Bermudez Rafael , Sargent Edward H. , Yang Xuyong 
Published: November 2021

AbstractLight‐emitting diodes (LEDs) in a tandem configuration offer a strategy to realize high‐performance, multicolor devices. Until now, though, the efficiency of tandem colloidal quantum dot LEDs (QLEDs) has been limited due to unpassivated interfaces and solvent damage originating from the materials processing requirements of interconnecting layers (ICLs). Here an ICL is reported consisting of a semiconductor‐metal‐dielectric stack that provides facile fabrication, materials stability, and good optoelectronic coupling. It is investigated experimentally how the ICL enables charge balance, suppresses current leakage, and prevents solvent damage to the underlying layers. As a result record efficiencies are reported for double‐junction tandem QLEDs, whose emission wavelengths cover from blue to red light; i.e., external quantum efficiencies (EQEs) of 40% (average 37+/−2%) for red, 49% (average 45+/−2%) for yellow, 50% (average 46+/−2%) for green, and 24% (average 21+/−2%) for blue are achieved.
Lamellar Bimetallic Thiolates: Synthesis, Characterization, and Their Utilization for the Preparation of Bimetallic Chalcogenide Nanocrystals through Mechanochemical Grinding
Authors: Bera Abhijit , Pathak Sushil S. , Kotha Vishal , Prasad Bhagavatula L. V. 
Published: November 2021

AbstractThiolates of single metal ions are known to exist as lamellar structures in the neat state and some of these metal thiolates can be delaminated into individual molecular sheets simply by adding a nonpolar organic solvent. It is established here that even bimetallic thiolates such as copper‐indium thiolate and silver‐indium thiolate exist as lamellar sheets. Each of these sheets consists of both metal ions arranged in a random fashion. It is also demonstrated that these bimetallic thiolates can be employed as single source precursors to prepare phase pure bimetallic chalcogenide nanocrystals (NCs) through mechanochemical routes by grinding them with an appropriate chalcogenide source. Notably, these bimetallic chalcogenide NCs, though synthesized in the absence of any solvent, get easily dispersed in nonpolar solvents as their surface is protected by the thiolate molecules released during the grinding process. These ternary NCs display a strong and tunable photoluminescence in the visible to near‐infrared region. Based on detailed systematic studies it is concluded that to obtain phase pure bimetallic sulfide/selenide NCs bimetallic thiolates, consisting of both metal ions in each sheet, must be used as single source precursors and physical mixtures of individual thiolates do not afford such phase pure materials.
L‐Cysteine‐Meditated Self‐Assembled PtRu Derived Bimetallic Metal–Carbon Hybrid: An Excellent Peroxidase Mimics for Colorimetric and Fluorometric Detection of Hydrogen Peroxide and Cholesterol
Authors: Gupta Pramod K. , Son Seong Eun , Seong Gi Hun 
Published: November 2021

AbstractArtificial enzymes have attracted considerable attention because of their significant advantages over natural enzymes. Herein, the authors report a simple hydrothermal strategy for producing a bimetallic metal — N‐, S‐doped carbon (NS‐C@PtRu) hybrid derived from L‐cysteine‐mediated self‐assembly of PtRu. The peroxidase‐like activity and colloidal stability of the NS‐C@PtRu are tuned by varying the amount of L‐cysteine, the source material for the N‐, S‐doped carbon. The NS‐C@PtRu exhibits good dispersibility, synergistic interactions (metal–metal, metal–carbon), non‐metal (N, S) doping, more catalytic active sites, improved noble metallic catalyst performance, and high utilization efficiency. As an excellent peroxidase mimic, NS‐C@PtRu catalyzes the oxidation of 3,3′,5′,5′‐tetramethylbenzidine (TMB), and Amplex Red (AR) substrates, producing colorimetric and fluorometric signals that offer efficient detection of H2O2. Furthermore, colorimetric and fluorometric cholesterol detection is proposed by combining cholesterol oxidase‐catalyzed cholesterol oxidation with NS‐C@PtRu‐catalyzed TMB/AR oxidation. The fluorometric cholesterol sensor exhibited a lower limit of detection of 1.4 µmol L−1 and rapid response, whereas the colorimetric sensor exhibited a wide detection range of 0.1–6 mmol L−1 and colorimetric changes that can be seen with the naked eyes. Both sensing methods demonstrated excellent selectivity and recovery in determining cholesterol in spiked human serum samples.
Nonwetting Nanostructured Hemostatic Material for Bleeding Control with Minimal Adhesion
Authors: Li Yuan , Niu Fei , Zhao Xiaotong , Yap Choon Hwai , Li Zhe 
Published: November 2021

AbstractHemostatic materials are widely used for bleeding control. However, existing blood‐absorbing wound dressing materials have two unaddressed challenges, blood loss through the hydrophilic material and strong clot adhesion that prevents gauze removal. Here, a nonwetting nanofiber structured material based on a two‐step spray coating procedure for hemostatic application is developed. Interfacial behaviors at the blood/clot‐material interface are exploited for bleeding control and minimizing wound adhesion. It is shown that this nonwetting material can retain blood within the wound, thus preventing blood loss. The nanofiber structure and kaolin microparticles collectively promote fast clotting to seal the wound and generate point‐to‐point contacts between clot and the nanofiber surface. These point‐to‐point contacts would subsequently be damaged by the interfacial shear induced by clot contraction, generating a peeling force significantly smaller than commercial low‐adherent or fast‐clotting hemostatic products. Its bleeding control and low adhesion properties are verified by in vivo animal experiments. The work therefore provides an efficient hemostatic material with excellent bleeding control and low wound adhesion properties, demonstrating an effective strategy to design advanced hemostatic materials by exploiting the interfacial behaviors.
Ferric Ions as a Catalytic Mediator in Metal‐EGCG Network for Bactericidal Effect and Pathogenic Biofilm Eradication at Physiological pH
Authors: Chen Shuai , Yan Yong , Yu Yue , Wang Zhenfeng , Zhu Xiaojun , Sun Liping , Li Chao , Wang Feng 
Published: November 2021

AbstractPathogenic bacteria and biofilm formation have become the urgent threats to global public health. Herein, metal‐epigallocatechin gallate (EGCG) network with improved bactericidal effect and pathogenic biofilm eradication ability via trivalent cationic Fe3+ catalyzed hydrogen peroxide (H2O2) decomposition is developed. EGCG, the predominant catechin from tea, is predicted to be a good chelator for eight metal ions (i.e., Al3+, Cr3+, Cu2+, Co2+, Zn2+, Mn2+, Ni2+, Fe3+). 3,3',5,5'‐tetramethylbenzidine oxidation experiment using UV–vis spectrometer demonstrated that Zn2+, Mn2+, Ni2+ are the potential candidates to accelerate the generation of H2O2 by EGCG. Compared with the other two metal‐EGCG network (Zn2+‐EGCG or Mn2+‐EGCG), only Ni2+‐EGCG network has better bactericidal property and plays a synergistic role in the network system. Furthermore, by introducing Fe3+ to Ni2+‐EGCG network, the complex exhibits the best bactericidal property for gram‐negative bacteria Escherichia coli (E. coli) and Pseudomonas aeruginosa (PAO1), which can be explained by the rapid H2O2 decomposition and associated production of hydroxyl radicals. With SYTO 9/PI staining assay, Fe3+ as a catalytic mediator in Ni2+‐EGCG network shows the most significant bactericidal effect and pathogenic biofilm eradication ability. According to the above analysis, Ni2+‐EGCG network presents a promising nanoplatform as an alternative to antibiotics for eradication of pathogenic bacteria and biofilms.