bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Genesis of Termination
Authors: Stannard John E , Capper David 
Published: February 2021

Abstract
This chapter explains how English law got to the point it is at now where it treats breach of condition and fundamental breach as the grounds on which a contract may be terminated. It differentiates between conditions and warranties. Breach of condition is where a contractual term of sufficient importance to justify the non-breaching party terminating the contract is breached. Breach of warranty is where the non-breaching party is only permitted an action for damages. The chapter then assesses the concepts of frustration and frustrating breach, and traces the history of the development of the law on frustration. A contract is frustrated when some unforeseeable supervening event occurs that without the fault of either party essentially destroys the bargain they have made. Where a contract is frustrated, both parties are released from their obligations of future performance.
Applications for Prompt Release of Vessels and Crews
Authors: Kittichaisaree Kriangsak 
Published: February 2021

Abstract
This chapter looks at applications for prompt release of vessels and crews detained after violating laws and regulations of a coastal State. Pursuant to Article 292(1) of the 1982 United Nations Convention on the Law of the Sea (UNCLOS), the International Tribunal for the Law of the Sea (ITLOS) has default jurisdiction over prompt release applications, unless the parties otherwise agree. The parties must be States Parties to UNCLOS and have not agreed to submit the question of release from detention to any other court or tribunal within ten days from the time of detention. Article 112 of the ITLOS Rules adds, inter alia, that ITLOS shall give priority to applications for release of vessels or crews over all other proceedings before ITLOS. In its judgment, ITLOS must determine in each case whether or not the allegation made by the applicant that the detaining State has not complied with a provision of UNCLOS for the prompt release of the vessel or the crew upon the posting of a reasonable bond or other financial security is well founded. If ITLOS decides the allegation is well founded, it shall determine the amount, nature, and form of the bond or financial security to be posted for the release of the vessel or the crew.
Responsible Practice or Restricted Practice? an Empirical Study of the Use of Clinical Guidelines in Medical Negligence Litigation
Authors: Samanta Ash , Samanta Jo , Beswick Joanne 
Published: February 2021

Abstract
In medical negligence litigation, the standard for breach of duty is measured against the Bolam test which reflects accepted practice. Despite protracted debate and common law development, the Bolam standard remains the touchstone for litigation in this area. Clinical guidelines (CGs) are statements based upon best available medical evidence and are designed to facilitate clinical decision-making to optimise outcomes thereby reflecting expected practice. Nevertheless, there is little research that considers how CGs engage in litigation and their influence on judicial reasoning. Given the increasing pressures on the NHS amid rising costs of litigation, these are important issues. This study provides an original contribution to the literature on CGs in determining breach of duty in law. Using a mixed methods’ approach, data from multiple sources have been gathered and analysed to assess the use of CGs by lawyers and the courts thereby adding to the discourse on the judicial shift away from deference to Bolam. It concludes by offering a conceptual basis for the use of CGs within a framework for reasonableness and promotes their principled use while avoiding constraints on expert testimony, experience, and exercise of clinical discretion. This study has relevance for academics, legal and medical practitioners, and policy makers.
The role of DNA polymerase ζ in benzo[a]pyrene-induced mutagenesis in the mouse lung
Authors: Ishii Yuji , Takasu Shinji , Grúz Petr , Masumura Kenichi , Ogawa Kumiko , Nohmi Takehiko , Umemura Takashi 
Published: February 2021

Abstract
DNA polymerase zeta (Polζ) is a heterotetramer composed of the catalytic subunit Rev3l, Rev7 and two subunits of Polδ (PolD2/Pol31 and PolD3/Pol32), and this polymerase exerts translesion DNA synthesis (TLS) in yeast. Because Rev3l knockout results in embryonic lethality in mice, the functions of Polζ need further investigation in vivo. Then, we noted the two facts that substitution of leucine 979 of yeast Rev3l with methionine reduces Polζ replication fidelity and that reporter gene transgenic rodents are able to provide the detailed mutation status. Here, we established gpt delta mouse knocked in the constructed gene encoding methionine instead of leucine at residue 2610 of Rev3l (Rev3l L2610M gpt delta mice), to clarify the role of Polζ in TLS of chemical-induced bulky DNA adducts in vivo. Eight-week-old gpt delta mice and Rev3l L2610M gpt delta mice were treated with benzo[a]pyrene (BaP) at 0, 40, 80, or 160 mg/kg via single intraperitoneal injection. At necropsy 31 days after treatment, lungs were collected for reporter gene mutation assays. Although the gpt mutant frequency was significantly increased by BaP in both mouse genotypes, it was three times higher in Rev3l L2610M gpt delta than gpt delta mice after treatment with 160 mg/kg BaP. The frequencies of G:C base substitutions and characteristic complex mutations were significantly increased in Rev3l L2610M gpt delta mice compared with gpt delta mice. The BaP dose–response relationship suggested that Polζ plays a central role in TLS when protective mechanisms against BaP mutagenesis, such as error-free TLS, are saturated. Overall, Polζ may incorporate incorrect nucleotides at the sites opposite to BaP-modified guanines and extend short DNA sequences from the resultant terminal mismatches only when DNA is heavily damaged.
Structural determinants of the IRF4/DNA homodimeric complex
Authors: Sundararaj Srinivasan , Seneviratne Sandali , Williams Simon J , Enders Anselm , Casarotto Marco G 
Published: February 2021

Abstract
Interferon regulatory factor 4 (IRF4) is a key transcription factor (TF) in the regulation of immune cells, including B and T cells. It acts by binding DNA as both a homodimer and, in conjunction with other TFs, as a heterodimer. The choice of homo and heterodimeric/ DNA interactions is a critical aspect in the control of the transcriptional program and cell fate outcome. To characterize the nature of this interaction in the homodimeric complex, we have determined the crystal structure of the IRF4/ISRE homodimeric complex. We show that the complex formation is aided by a substantial DNA deformation with co-operative binding achieved exclusively through protein–DNA contact. This markedly contrasts with the heterodimeric form where DNA bound IRF4 is shown to physically interact with PU.1 TF to engage EICE1. We also show that the hotspot residues (Arg98, Cys99 and Asn102) contact both consensus and non-consensus sequences with the L1 loop exhibiting marked flexibility. Additionally, we identified that IRF4L116R, a mutant associated with chronic lymphocytic leukemia, binds more robustly to DNA thereby providing a rationale for the observed gain of function. Together, we demonstrate key structural differences between IRF4 homo and heterodimeric complexes, thereby providing molecular insights into IRF4-mediated transcriptional regulation.
COVID-19 Testing Results by HIV Status, March–July 2020, Chicago, USA
Authors: Pyra Maria , Rusie Laura , Houlberg Magda , Balthazar Christopher , Montgomery Jerome , Hotton Anna , Yang Wenho , Betanzos Mateo , Green Maya , Schneider John 
Published: February 2021

Abstract
The role of HIV in coronavirus disease 2019 acquisition is not yet understood. Among 1862 patients, including 349 people with HIV—with most of these being virally suppressed and 308 having recently used pre-exposure prophylaxis—we compared rates of positive polymerase chain reaction results. Positivity was higher among people with HIV (10.6%) compared with HIV-negative patients (7.1%) but was not significant in adjusted models.
Comparison of All-Cause Mortality Between Individuals With COVID-19 and Propensity Score–Matched Individuals Without COVID-19 in South Korea
Authors: Oh Tak Kyu , Song In-Ae , Song Kyoung-Ho , Jeon Young-Tae 
Published: February 2021

Abstract

Background
We compared all-cause mortality between individuals in South Korea with and without coronavirus disease 2019 (COVID-19) using propensity score (PS) matching.

Methods
This population-based cohort study used data from the National Health Insurance Service COVID-19 cohort database. In the database, we included individuals (COVID-19 patients, control population, and test-negative individuals) aged 20 years or older, regardless of hospitalization. The primary end point was all-cause mortality between January 1, 2020, and August 27, 2020.

Results
A total of 328 374 adults were included in the study: 7713 and 320 660 in the COVID-19 group and the control group. After PS matching, a total of 15 426 individuals (7713 per group) were included in the analysis. All-cause mortality was 3.2% (248/7713) and 1.6% (126/7713) in the COVID-19 group and the control group, respectively. In Cox regression analysis after PS matching, the risk of death in the COVID-19 group was twice as high (hazard ratio, 2.00; 95% CI, 1.61–2.48; P &lt; .001) as that in the control group. Among patients aged ≥60 years, the COVID-19 group had a 2.32-fold higher all-cause mortality compared with the control group, while statistically significant differences were not observed in the age groups 20–39 years (P = .339) and 40–59 years (P = .562).

Conclusions
In South Korea, all-cause mortality was twice as high among individuals with COVID-19 as among those with similar underlying risks, primarily because of the elevated COVID-19-associated mortality in those aged ≥60 years. Our results highlight the need for prevention of COVID-19 with respect to mortality as a public health outcome.
Geochemical Distinction Between Altered Oceanic Basalt- and Seafloor Sediment-Derived Fluids in the Mantle Source of Mafic Igneous Rocks in Southwestern Tianshan, Western China
Authors: Ma Li-Tao , Dai Li-Qun , Zheng Yong-Fei , Zhao Zi-Fu , Fang Wei , Zhao Kai , Xiao Yilin , Tong Fengtai 
Published: February 2021

AbstractThe role of subducting oceanic crust-derived fluids in generating mafic arc magmatism has been widely documented. However, the subducting oceanic crust is generally composed of basaltic igneous crust and seafloor sediment, which may give rise to different compositions of liquid phases causing metasomatism of the mantle wedge. Because of the similarity in enrichment of fluid-mobile incompatible elements in the two sources of subduction zone fluids, it has been a challenge to distinguish between them when studying the products of mafic arc magmatism. This difficulty is overcome by a combined study of whole-rock Li isotopes and zircon O isotopes in addition to whole-rock major-trace elements and Sr–Nd–Hf isotopes in Late Paleozoic mafic igneous rocks from southwestern Tianshan in western China. Zircon U–Pb dating yields consistent ages of 313 ± 3 Ma to 305 ± 1 Ma for magma crystallization. The mafic igneous rocks exhibit arc-like trace element distribution patterns and depleted whole-rock Nd–Hf isotopes but slightly high (87Sr/86Sr)i ratios of 0·7039– 0·7057. They also show positive zircon εHf(t) values and slightly higher zircon δ18O values of 5·2–7·6‰. There are covariations of whole-rock Sr isotopes with Th/La and Rb/Nb ratios, indicating a contribution from terrigenous sediment-derived fluids to their mantle source in addition to basaltic igneous crust-derived fluids. Based on the slightly higher zircon δ18O values but variably lower whole-rock δ7Li values of -0·8 to 3·5‰ for the target rocks than those of mantle respectively, both altered oceanic basalt- and terrigenous sediment-derived fluids are identified in the mantle source of these mafic igneous rocks. Model calculations for trace elements and Sr–Nd–Li isotopes further confirm that the geochemical compositions of these mafic igneous rocks can be explained by chemical reaction of depleted MORB mantle peridotite with the mixed fluids to generate ultramafic metasomatites at subarc depths. Therefore, chemical metasomatism of the mantle wedge is a key mechanism for the incorporation of crustal components into the source of arc-like mafic igneous rocks above oceanic subduction zones.
Hexose transporter CsSWEET7a in cucumber mediates phloem unloading in companion cells for fruit development
Authors: Li Yaxin , Liu Huan , Yao Xuehui , Wang Jiang , Feng Sheng , Sun Lulu , Ma Si , Xu Kang , Chen Li-Qing , Sui Xiaolei 
Published: February 2021

Abstract
In the fleshy fruit of cucumbers (Cucumis sativus L.), the phloem flow is unloaded via an apoplasmic pathway, which requires protein carriers to export sugars derived from stachyose and raffinose into the apoplasm. However, transporter(s) involved in this process remain unidentified. Here, we report that a hexose transporter, CsSWEET7a (Sugar Will Eventually be Exported Transporter 7a), was highly expressed in cucumber sink tissues and localized to the plasma membrane in companion cells of the phloem. Its expression level increased gradually during fruit development. Down-regulation of CsSWEET7a by RNA interference (RNAi) resulted in smaller fruit size along with reduced soluble sugar levels and reduced allocation of 14C-labelled carbon to sink tissues. CsSWEET7a overexpression lines showed an opposite phenotype. Interestingly, genes encoding alkaline α-galactosidase (AGA) and sucrose synthase (SUS) were also differentially regulated in CsSWEET7a transgenic lines. Immunohistochemical analysis demonstrated that CsAGA2 co-localized with CsSWEET7a in companion cells, indicating cooperation between AGA and CsSWEET7a in fruit phloem unloading. Our findings indicated that CsSWEET7a is involved in sugar phloem unloading in cucumber fruit by removing hexoses from companion cells to the apoplasmic space to stimulate the raffinose family of oligosaccharides (RFOs) metabolism so that additional sugars can be unloaded to promote fruit growth. This study also provides a possible avenue towards improving fruit production in cucumber.
The Impact of Lockdown on Police Service Calls During the COVID-19 Pandemic in China
Authors: Dai Mengliang , Xia Yiwei , Han Rongxu 
Published: February 2021

Abstract
Police service calls have been studied widely in the Western context, but they are rarely discussed in the Chinese context. For the context of this study, it is important to note that the Chinese authorities implemented the strictest lockdown after the COVID-19 pandemic began. Drawing on the data from a county-level city in Hubei province, this study examines changes in the quantity and nature of 110 service calls before, during, and after the COVID-19 pandemic lockdown. The results indicate that the average weekly call numbers before and after the lockdown were higher than during the lockdown. Meanwhile, different call types produced different patterns, though the weekly call totals decreased during the lockdown. There was a significant decrease in crime, traffic, and dispute calls, but a substantial increase in calls related to domestic violence, public security, and other issues. Changes in the frequency of different call types pose challenges to police departments. These findings will have implications for deploying police forces and allocating resources within the pandemic crisis in particular.
The first-order symmetry operator on gravitational perturbations in the 5D Myers–Perry spacetime with equal angular momenta
Authors: Tsuchiya Masataka , Houri Tsuyoshi , Moon Yoo Chul 
Published: February 2021

Abstract
It has been revealed that the first-order symmetry operator for the linearized Einstein equation on a vacuum spacetime can be constructed from a Killing–Yano 3-form. This might be used to construct all or part of the solutions to the field equation. In this paper, we perform a mode decomposition of a metric perturbation on the Schwarzschild spacetime and the Myers–Perry spacetime with equal angular momenta in 5 dimensions, and investigate the action of the symmetry operator on specific modes concretely. We show that, on such spacetimes, there is no transition between the modes of a metric perturbation by the action of the symmetry operator, and it ends up being the linear combination of the infinitesimal transformations of isometry.
No indigenous peoples left behind on the rolling out of COVID-19 vaccines: considerations and predicaments
Authors: Sarmiento Philip Joseph D , Serrano Jose P , Ignacio Ria P , Cruz Arlan E dela , De Leon Jonald C 
Published: February 2021

AbstractIn recent correspondences, authors emphasized the need to consider vulnerable groups such as migrants, refugees, prisoners, and persons with disabilities in the interventions and plans of government and health authorities in combatting coronavirus disease 2019 (COVID-19). This paper discusses the urgent call for government and health authorities to ensure that indigenous peoples, being distinct ethnic communities, are included in the rolling out of COVID-19 vaccines with considerations to their unique culture, beliefs and traditions.
Clinical impact of myositis-specific autoantibodies on long-term prognosis of juvenile idiopathic inflammatory myopathies: multicentre study
Authors: Yamasaki Yuichi , Kobayashi Norimoto , Akioka Shinji , Yamazaki Kazuko , Takezaki Shunichiro , Nakaseko Haruna , Ohara Asami , Nishimura Kenichi , Nishida Yutaka , Sato Satoshi , Kishi Takayuki , Hashimoto Motomu , Mori Masaaki , Okazaki Yuka , Kuwana Masataka , Ohta Akiko 
Published: February 2021

Abstract

Objectives
This study aimed to investigate the clinical characteristics, treatment and prognosis of juvenile idiopathic inflammatory myopathies (JIIM) in Japan for each myositis-specific autoantibody (MSA) profile.

Methods
A multicentre, retrospective study was conducted using data of patients with JIIM at nine paediatric rheumatology centres in Japan. Patients with MSA profiles, determined by immunoprecipitation using stored serum from the active stage, were included.

Results
MSA were detected in 85 of 96 cases eligible for the analyses. Over 90% of the patients in this study had one of the following three MSA types: anti-melanoma differentiation-associated protein 5 (MDA5) (n = 31), anti-transcriptional intermediary factor 1 alpha and/or gamma subunits (TIF1γ) (n = 25) and anti-nuclear matrix protein 2 (NXP2) (n = 25) antibodies. Gottron papules and periungual capillary abnormalities were the most common signs of every MSA group in the initial phase. The presence of interstitial lung disease (ILD) was the highest risk factor for patients with anti-MDA5 antibodies. Most patients were administered multiple drug therapies: glucocorticoids and MTX were administered to patients with anti-TIF1γ or anti-NXP2 antibodies. Half of the patients with anti-MDA5 antibodies received more than three medications including i.v. CYC, especially patients with ILD. Patients with anti-MDA5 antibodies were more likely to achieve drug-free remission (29 vs 21%) and less likely to relapse (26 vs 44%) than others.

Conclusion
Anti-MDA5 antibodies are the most common MSA type in Japan, and patients with this antibody are characterized by ILD at onset, multiple medications including i.v. CYC, drug-free remission, and a lower frequency of relapse. New therapeutic strategies are required for other MSA types.
Burkitt lymphoma: Age Specific Fertility Rate in 113 long-term female survivors after treatment with cyclophosphamide
Authors: Hesseling PhD Peter B , Afungchwi MSc Glenn M , Njamshi Dip. Nursing Vera , Kruger PhD Mariana , Kimbi Dip Nursing Comfort , Nfor BSc Patience , Wharin MD Paul , Draper MSc Heather , Kouya MD Francine 
Published: February 2021

Abstract

Introduction
Reduced fertility risk is a risk in females treated with a high cumulative cyclophosphamide (CPM) dose.

Objectives
The objective of this study is to establish the age at menarche, record all pregnancies, calculate age-specific fertility rate (ASFR) in female BL survivors, treated in Cameroon, in the age groups 15–19 and 20–24 years, and association with an increasing cumulative CPM dose.

Methods
Data collection included personal data and telephone interviews for female survivors, aged ≥12 years with regards to menarche age, their mothers’ menarche age, incidence and outcome of all pregnancies. The cumulative CPM/m2 dose was categorized as low (&lt;4723 mg/m2), medium (4724–10 635 mg/m/2) or high (&gt;10 635 mg/m2).

Results
The median age at first treatment for 113 patients was 8 years (range 3–17 years), with median current age 17 years (range 12–26 years); the median duration of follow-up was 9 years (range 1.2–13.3 years). The median age of patients at menarche (n = 109; 4 unknown) was 14 years (range 10–17 years, SD 1.19) and that of their mothers (n = 68; 45 unknown) 15 years (range 10–17 years, SD 1.53). The median time to first pregnancy following menarche (the fertility time) was 3.04 years (n = 10) with low-dose CPM, 6.09 years with medium-dose CPM (n = 81) and 6.04 years with high-dose CPM (n = 32) (log rank difference p = 0.420). The ASFR in the age group 15–19 years was 82.19 (n = 73) and in the age group 20–24 years was 863.6 (n = 22), with significantly lower ASFR (p &gt; 0.001) in children treated before the age of 10 years.

Conclusion
Fertility rates of girls treated for BL with CPM were normal but reduced in patients who commenced treatment before the age of 10 years.
COVID-19 and international sale contracts: unprecedented grounds for exemption or business as usual?
Authors: Janssen André , Wahnschaffe Christian Johannes 
Published: February 2021

Abstract
The year 2020 has witnessed a health crisis of unparalleled dimensions that has triggered ongoing complications on a global scale. Through restrictions on economic activities and disruptions in supply chains, COVID-19 has severely impeded global trade. Among the ensuing problems, the question of excusing a party’s failure to perform its contractual obligations is of key interest. This contribution analyses the conditions for exemption from liability with view to contracts for the international sale of goods subject to the 1980 UN Convention on Contracts for the International Sale of Goods. It revisits the statutory requirements and illustrates COVID-19 scenarios that might satisfy the relevant thresholds. This article further examines the particular legal consequences following from an exemption from liability, including the controversial discussion as to the adequate remedies in cases of economic hardship. Finally, this contribution addresses the newly revised International Chamber of Commerce’s clauses on force majeure and hardship.