bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intelligent automation in hospitality: exploring the relative automatability of frontline food service tasks
Authors: Tuomi Aarni , Ascenção Mário Passos 
Published: November 2021

PurposeAutomation poses to change how service work is organized. However, there is a lack of understanding of how automation influences specific sectors, including specific hospitality jobs. Addressing this gap, this paper looks at the relative automatability of jobs and tasks which fall within one specific hospitality context: frontline food service.Design/methodology/approachStudy 1 analyzes the UK Office for National Statistics' Standard Occupational Classification (2020) data to determine the degree to which frontline food service jobs consist of tasks requiring mechanical, analytical, intuitive or empathetic intelligence. Study 2 contrasts these findings to current state of intelligent automation technology development through interviews and a focus group with food service technology experts (n = 13).FindingsOf all the tasks listed under food service in the ONS SOC 2020, 58.8% are found to require mechanical, 26.8% analytical, 11.3% intuitive and 3.1% empathetic intelligence. Further, the automatability of these tasks is found to be driven by three streams of technology development in particular: (1) autonomous navigation, (2) object manipulation and (3) natural language processing.Originality/valueHospitality management literature has started to conceptualize a move from mechanical and analytical service tasks to tasks centered around intuition and empathy. While previous studies have adopted a general view to what this might mean for hospitality jobs, this paper develops a novel, task-centric framework for Actioning Intelligent Automation in Frontline Food Service.
Hsp90 regulates the tumorigenic function of tyrosine protein kinase in osteosarcoma
Authors: Yao Zhao‐Peng , Zhu Hui , Shen Feng , Gong Dan 
Published: November 2021

AbstractDespite recent advances in diagnosis and treatment, osteosarcoma remains as the most common bone cancer in children and is associated with poor prognosis. Growing evidence has supported dysregulation of threonine and tyrosine protein kinase (TTK) expression as a hallmark of multiple cancers, however, its function in osteosarcoma remains to be elucidated. In the present study, we found that TTK was frequently overexpressed in osteosarcoma and associated with increased tumour growth and progression. Moreover, using both in vitro and in vivo assays, we provided evidence that TTK level was regulated by a molecular chaperone, heat shock protein 90 (Hsp90). Hsp90 directly interacted with TTK and prevents proteasome‐dependent TTK degradation, leading to the accumulation of TTK in osteosarcoma cells. Elevated TTK promoted cancer cell proliferation and survival by activating cell‐cycle progression and inhibiting apoptosis. Consistently, depletion of TTK by Hsp90 inhibition induced cell‐cycle arrest, generated aneuploidy and eventually resulted in apoptotic cancer cell death. Together, our study revealed an important Hsp90‐TTK regulatory axis in osteosarcoma cells to promote cancer cell growth and survival. These findings expand our knowledge on osteosarcoma pathogenesis and offer novel therapeutic options for clinical practice.
Score manipulation, density continuity and intent‐to‐treat effect for regression discontinuity
Authors: Choi Jin‐young , Lee Myoung‐jae 
Published: November 2021

AbstractRegression discontinuity (RD) is widely used in many disciplines of science to find treatment effect when the treatment is determined by an underlying running variable (‘score') crossing a cutoff or not. The main attraction of RD is local randomization around , which is, however, often ruined by manipulation on . To detect manipulation, the continuity of score density function at is routinely tested in practice. In this paper, we examine how informative is for RD, and show the following. First, for incumbency effect in election to which RD has been heavily applied, may have no information content. Second, for RD in general, the continuity is neither necessary nor sufficient for RD validity. Third, if the treatment cannot be implemented without manipulation of , then the manipulation had better be considered as part of the treatment effect, much as in ‘intent‐to‐treat effect’ for clinical trials. These findings call for relying less on continuity tests and, instead, thinking more about how subjects react to the treatment to modify their , how to design the treatment to lessen manipulation, and what to take as the desired treatment effect.
Evaluating the effect of conjugation on the bioactivities of whey protein hydrolysates
Authors: Minj Shayanti , Anand Sanjeev , Martinez‐Monteagudo Sergio 
Published: November 2021

AbstractIn this study, the ability of a whey protein hydrolysate to exhibit the antimicrobial, antioxidant, and antihypertensive behavior after combining with a reducing carbohydrate was studied. Whey protein hydrolysates with varying degrees of hydrolysis (WPH10, WPH15, and WPH20) were determined for their antimicrobial, antioxidant, and antihypertensive activities. Of these, hydrolysate (WPH10) exhibited the highest antimicrobial activity (with 10–11.2 mm zone of inhibition) against tested microorganisms: Listeria innocua, Staphylococcus aureus, and Bacillus coagulans. Also, the WPH10 exhibited the highest antioxidant (866.56 TEAC µmol/L) and antihypertensive (67.52%) attributes. Hence, based on the highest bioactivity, hydrolysate WPH10 was selected for conjugation with maltodextrin, and the effect of conjugation on the bioactivities was evaluated. The conjugated WPH10 solution demonstrated higher antimicrobial (17.16 mm) and antioxidant activity (1044.37 TEAC µmol/L), whereas a slight decrease in the antihypertensive activity (65.4%) was observed, as compared to WPH10 alone. The conjugated solution was further spray dried and alternatively, freeze‐dried. The dried WPH10 conjugate exhibited even higher antimicrobial (18.5 mm) and antioxidant activity (1268.89 TEAC µmol/L) while retaining the antihypertensive activity (65.6%). Overall, the results indicate the ability of the WPH10‐maltodextrin to retain the bioactive behavior after combining with a reduced carbohydrate.Practical ApplicationWhey protein hydrolysates upon conjugation with carbohydrates retain the bioactive properties of whey protein, which provides opportunities for application as an ingredient to develop novel health formulations.
Use of betel leaf (Piper betle L.) ethanolic extract in combination with modified atmospheric packaging and nonthermal plasma for shelf‐life extension of Nile tilapia (Oreochromis niloticus) fillets
Authors: Tagrida Mohamed , Benjakul Soottawat , Zhang Bin 
Published: November 2021

AbstractFish is perishable and has the short shelf‐life. To maintain its quality, it is necessary to implement the appropriate technology, particularly nonthermal processing along with safe additive, especially from plant origin under the concept of "hurdle technology". The use of potential vesicle including liposome for loading the plant extract could be a means to enhance the stability and activities of the extract. The current study aimed to evaluate the effect of liposomes loaded with betel leaf ethanolic extract (L/BLEEs) or unencapsulated BLEE (U/BLEE) in conjunction with modified atmospheric packaging (MAP) and nonthermal plasma (NTP) on the quality changes and shelf‐life of Nile tilapia fillets (TFs) stored under refrigerated condition (4°C). TFs treated with L/BLEE or U/BLEE at 400 ppm, packed under modified atmosphere (CO2:Ar:O2 = 60:30:10) and subjected to NTP for 300 s (L/BLEE‐400/MAP‐NTP and U/BLEE‐400/MAP‐NTP, respectively) had the lowest microbial and chemical changes during storage, while the control showed the highest changes (p < 0.05). Lipid oxidation was lower in these samples, ascertained by more retained polyunsaturated fatty acids and lower lipid oxidation based on Fourier transform infrared (FT‐IR) spectra. Overall likeness scores were similar (p > 0.05) between all the samples at day 0 of storage. Only L/BLEE‐400/MAP‐NTP and U/BLEE‐400/MAP‐NTP were still sensorially acceptable after 12 days at 4°C. Therefore, L/BLEE or U/BLEE combined with MAP/NTP treatment could be adopted as a potent hurdle for shelf‐life extension of TFs.Practical ApplicationNatural additives and nonthermal processing technologies have gained increasing interest for preservation of fish. Liposomes loaded with betel leaf ethanolic extract (L/BLEE) rich in polyphenolics could be used together with modified atmospheric packaging (MAP) and nonthermal plasma (NTP) to retard bacterial growth and chemical deterioration in Nile tilapia fillets. These hurdles were proven to be able to maintain the qualities of tilapia fillets stored at 4°C up to 12 days, especially when L/BLEE was used at 400 ppm. Therefore, shelf‐life extension of Nile tilapia fillets or other fish can be achieved by using the natural additive and nonthermal processing technologies.
MetaComNet: A random forest‐based framework for making spatial predictions of plant–pollinator interactions
Authors: Sydenham Markus A. K. , Venter Zander S. , Reitan Trond , Rasmussen Claus , Skrindo Astrid B. , Skoog Daniel I. J. , Hanevik Kaj‐Andreas , Hegland Stein Joar , Dupont Yoko L. , Nielsen Anders , Chipperfield Joseph , Rusch Graciela M. 
Published: November 2021

Abstract

Predicting plant–pollinator interaction networks over space and time will improve our understanding of how environmental change is likely to impact the functioning of ecosystems. Here we propose a framework for producing spatially explicit predictions of the occurrence and number of pairwise plant–pollinator interactions and of the species richness, diversity and abundance of pollinators visiting flowers. We call the framework ‘MetaComNet’ because it aims to link metacommunity dynamics to the assembly of ecological networks.

To illustrate the MetaComNet functionality, we used a dataset on bee–flower networks sampled at 16 sites in southeast Norway along with random forest models to predict bee–flower interactions. We included variables associated with climatic conditions (elevation) and habitat availability within a 250 m radius of each site. Regional commonness, site‐specific distance to conspecifics, social guild and floral preference were included as bee traits. Each plant species was assigned a score reflecting its site‐specific abundance, and four scores reflecting the bee species that the plant family is known to attract. We used leave‐one‐out cross‐validations to assess the models' ability to predict pairwise plant–bee interactions across the landscape.

The relationship between observed occurrence or absence of interactions and the predicted probability of interactions was nearly proportional (GLMlogistic regression slope = 1.09), matching the data well (AUC = 0.88), and explained 30% of the variation. Predicted probability of interactions was also correlated with the number of observed pairwise interactions (r = 0.32). The sum of predicted probabilities of bee–flower interactions were positively correlated with observed species richness (r = 0.50), diversity (r = 0.48) and abundance (r = 0.42) of wild bees interacting with plant species within sites.

Our findings show that the MetaComNet framework can be a useful approach for making spatially explicit predictions and mapping plant–pollinator interactions. Such predictions have the potential to identify areas where the pollination potential for wild plants is particularly high, and where conservation action should be directed to preserve this ecosystem function.
Clinical factors associated with significant coronary lesions following out‐of‐hospital cardiac arrest
Authors: Helfer David R. , Helber Andrew R. , Ferko Aarika R. , Klein Daniel D. , Elchediak Daniel S. , Deaner Traci S. , Slagle Dustin , White William B. , Buckler David G. , Mitchell Oscar J. L. , Fiorilli Paul N. , Isenberg Derek , Nomura Jason , Murphy Kathleen A. , Sigal Adam , Saif Hassam , Reihart Michael J. , Vernon Tawnya M. , Abella Benjamin S. 
Published: November 2021

AbstractObjectivesOut‐of‐hospital cardiac arrest (OHCA) afflicts >350,000 people annually in the United States. While postarrest coronary angiography (CAG) with percutaneous coronary intervention (PCI) has been associated with improved survival in observational cohorts, substantial uncertainty exists regarding patient selection for postarrest CAG. We tested the hypothesis that symptoms consistent with acute coronary syndrome (ACS), including chest discomfort, prior to OHCAs are associated with significant coronary lesions identified on postarrest CAG.MethodsWe conducted a multicenter retrospective cohort study among eight regional hospitals. Adult patients who experienced atraumatic OHCA with successful initial resuscitation and subsequent CAG between January 2015 and December 2019 were included. We collected data on prehospital documentation of potential ACS symptoms prior to OHCA as well as clinical factors readily available during postarrest care. The primary outcome in multivariable regression modeling was the presence of significant coronary lesions (defined as >50% stenosis of left main or >75% stenosis of other coronary arteries).ResultsFour‐hundred patients were included. Median (interquartile range) age was 59 (51–69) years; 31% were female. At least one significant stenosis was found in 62%, of whom 71% received PCI. Clinical factors independently associated with a significant lesion included a history of myocardial infarction (adjusted odds ratio [aOR] = 6.5, [95% confidence interval {CI} = 1.3 to 32.4], p = 0.02), prearrest chest discomfort (aOR = 4.8 [95% CI = 2.1 to 11.8], p ≤ 0.001), ST‐segment elevations (aOR = 3.2 [95% CI = 1.7 to 6.3], p < 0.001), and an initial shockable rhythm (aOR = 1.9 [95% CI = 1.0 to 3.4], p = 0.05).ConclusionsAmong survivors of OHCA receiving CAG, history of prearrest chest discomfort was significantly and independently associated with significant coronary artery lesions on postarrest CAG. This suggests that we may be able to use prearrest symptoms to better risk stratify patients following OHCA to decide who will benefit from invasive angiography.
Effectiveness comparison between endometrial receptivity array, immune profiling and the combination in treating patients with multiple implantation failure
Authors: Jia Yan , Dong Ya‐Jun , Sha Yu‐Lin , Cai Song‐Chen , Diao Liang‐Hui , Qiu Zhu , Guo Yan‐Hua , Huang Yan , Ye Hong‐Xia , Liu Su 
Published: November 2021

AbstractProblemThe clinical value of endometrial receptivity array (ERA), endometrial immune profiling, or a combination of both for multiple implantation failure patients is unclear.Method of studyOne hundred and seventy‐two women with a history of at least two or more consecutive implantation failures in IVF/ICSI treatment were included. According to patients’ willingness, they were divided into four groups, ‘no treatment’, ‘Immune Profiling’, ‘ERA’ and ‘ERA + Immune Profiling’. Endometrial biopsy was examined by ERA, immune profiling alone, or combination, and intention was adopted accordingly. Pregnancy outcomes were compared, and the association between ERA phases and endometrial immune profiling was also assessed.ResultsThe overall incidence rate of the displaced window of implantation (WOI) and endometrial immune dysregulations were 84.9% and 75.3%, respectively. Implantation rate was significantly higher in the ‘ERA + Immune Profiling’ group than the ‘no treatment’ group (P = .007). Clinical pregnancy rate was somewhat improved in the three treatment groups but with a borderline significance (P = .071). After controlling for other confounders, ‘ERA + Immune Profiling’ treatment was associated with a higher pregnancy rate [aOR (95%CI)  =  3.412 (1.387–8.395), P = .008]. There was no association between endometrial immune profiling and ERA phases.ConclusionsOur findings highlight the high incidence of displaced WOI and endometrial immune dysregulation in multiple implantation failure patients. The combination of ERA and endometrial immune profiling is more likely to have clinical value than ERA or immune profiling alone. These data suggested the unsubstitutability of ERA and endometrial immune profiling on the treatment outcome for multiple implantation failure patients.
Ureteric injuries during hysterectomy—A Norwegian retrospective study of occurrence and claims for compensation over an 11‐year period
Authors: Ravlo Merethe , Moen Mette Haase , Bukholm Ida Rashida Khan , Lieng Marit , Vanky Eszter 
Published: November 2021

AbstractIntroductionUreteric injury is a rare but serious, iatrogenic complication of hysterectomy. The risk depends on indication for surgery, predisposing risk factors, and peroperative conditions. Our aims were to evaluate and learn from compensation claims to The Norwegian System of Patient Injury Compensation (NPE) for ureteric injury occurring during hysterectomies to predict risk factors, time of identification, symptoms, and consequences, and to relate these cases to injuries registered in The Norwegian Patient Registry.Material and methodsA retrospective study of ureteric injuries occurring during hysterectomies, reported to NPE and the Norwegian Patient Registry from 2009 through 2019.ResultsDuring the study period, 53 096 hysterectomies were registered in The Norwegian Patient Registry, of which ureteric injury was documented in 643 (1.2%). More ureteric injuries were registered in large hospital trusts than in small trusts (1.3% vs. 0.7%, p < 0.05). NPE received 69 claims due to ureteric injury occurring during hysterectomy, comprising 11% of all injuries in the study period. Compensation was approved for 15%. Women who claimed compensation were younger (48.1 ± 8.9 years vs. 55.1 ± 13.6 years, p < 0.01), more likely to have had a benign diagnosis (89.9% vs. 52.1%, p < 0.01), and more likely to have had the ureteric injury recognized after discharge (58.0% vs. 33.0%, p < 0.001) compared with non‐complainants. Identification of the ureters during the hysterectomy was documented in 30% of the NPE patient files. Additional information for the NPE cases included the following. The most common symptoms of unidentified injury were pain (77%), fever (12%), urinary leakage (13%), and anuria (8%). Re‐operation was necessary in 77% of the cases, and 10% of the women lost one kidney. Long‐term consequences after repair, such as loss of a kidney or persistent pain, were seen in 17%. No women died because of the injury.ConclusionsThe incidence of ureteric injury occurring during hysterectomy in Norway was 1.2%; 11% involved a claim for compensation, and 15% of these had their case approved. Most ureteric injuries were not recognized during the hysterectomy. Documentation of peroperative identification of the ureters during hysterectomy was often missing. Vigilance to pain as a postoperative symptom of peroperative unrecognized ureteric injury may result in earlier diagnosis and treatment.
Anterior segment involvement in Epstein–Barr virus: a review
Authors: Alba‐Linero Carmen , Rocha‐de‐Lossada Carlos , Rachwani‐Anil Rahul , Sainz‐de‐la‐Maza Maite , Sena‐Corrales Gabriel , Romano Vito , Rodríguez‐Calvo‐de‐Mora Marina 
Published: November 2021

AbstractThe aim of this study is to describe the involvement of Epstein–Barr Virus (EBV) in the diseases of the ocular anterior segment. This is a narrative review designed using the PUBMED, SCOPE and Web of Science databases, searching for reported literature on findings in the anterior ocular segment related to EBV between 1990 and 2020. Epstein–Barr Virus (EBV) is implicated in the development of salmon‐coloured conjunctival masses in the context of acute mononucleosis and lymphoproliferative disorders. Moreover, EBV can cause haemorrhagic conjunctivitis and its corneal implications appear as different types of keratitis patterns. The involvement of EBV in the pathogenesis of anterior segment inflammation is not well‐defined. Current evidence regarding anterior segment disease caused by EBV infection has been proved by positive viral detection through polymerase chain reaction test in eyes with lymphoproliferative disorders known to be caused by EBV, as B‐ and NK/T‐cell lymphoid tumours. Antiviral treatment (oral Aciclovir or Valaciclovir) in anterior segment disease caused by EBV remains controversial.
A virtual reality‐based study of color contrast to encourage more sustainable food choices
Authors: Wan Xiaoang , Qiu Linbo , Wang Chujun 
Published: November 2021

AbstractIn order to identify effective strategies to increase more environmentally friendly food choices, we conducted an experimental study to examine how the color contrast between the food and the background might influence people's choices between meat and vegetable dishes. Participants were instructed to choose three desirable dishes out of a choice set presented on a red‐ or green‐colored table in a simulated restaurant environment. Each choice set consisted of two meat and two vegetable dishes, so the participants had to choose between the meat‐heavy and vegetable‐forward meals. The participants chose the meat‐heavy meals more often than the chance level. However, the results revealed that using a red table to present the choice set could shift them toward choosing fewer meat‐heavy meals and thus more vegetable‐forward meals, and the visual attractiveness of the meat dishes was decreased when presented on the red tables. These findings provide empirical evidence regarding how the contrast between the color of food and the background color of the dining table can be used to modulate the sensory appeal of foods in order to promote sustainable food choices.
Targeting the OXE receptor with a selective antagonist inhibits allergen‐induced pulmonary inflammation in non‐human primates
Authors: Cossette Chantal , Miller Lisa A. , Ye Qiuji , Chourey Shishir , Reddy Chintam Nagendra , Rokach Joshua , Powell William S. 
Published: November 2021

Background and PurposeThe 5‐lipoxygenase product, 5‐oxo‐ETE (5‐oxo‐6,8,11,14‐eicosatetraenoic acid), is a potent chemoattractant for eosinophils and neutrophils. However, little is known about its pathophysiological role because of the lack of a rodent ortholog of the oxoeicosanoid (OXE) receptor. The present study aimed to determine whether the selective OXE receptor antagonist S‐Y048 can inhibit allergen‐induced pulmonary inflammation in a monkey model of asthma.Experimental ApproachMonkeys sensitized to house dust mite antigen (HDM) were treated with either vehicle or S‐Y048 prior to challenge with aerosolized HDM, and bronchoalveolar (BAL) fluid was collected 24 h later. After 6 weeks, animals that had initially been treated with vehicle received S‐Y048 and vice versa for animals initially treated with S‐Y048. Eosinophils and neutrophils in BAL and lung tissue samples were evaluated, as well as mucus‐containing cells in bronchi.Key ResultsHDM significantly increased the numbers of eosinophils, neutrophils, and macrophages in BAL fluid 24 h after challenge. These responses were all significantly inhibited by S‐Y048, which also reduced the numbers of eosinophils and neutrophils in lung tissue 24 h after challenge with HDM. S‐Y048 also significantly reduced the numbers of bronchial epithelial cells staining for mucin and MUC5AC after antigen challenge.Conclusion and ImplicationsThis study provides the first evidence that 5‐oxo‐ETE may play an important role in inducing allergen‐induced pulmonary inflammation and could also be involved in regulating MUC5AC in goblet cells. OXE receptor antagonists such as S‐Y048 may useful therapeutic agents in asthma and other eosinophilic as well as neutrophilic diseases.