bluuebunny/crossref_metadata_2025_split huggingface dataset:
CARDIOMIOPATIA DE TAKOTSUBO: UMA REVISÃO DOS ACHADOS E UM RELATO DE CASO DA VARIANTE TAKOTSUBO INVERTIDA
Authors: Sacomam Fabricio Dos Santos , Sodré Larissa Kerr de Araújo , Ueda Leandro Shigueru Ikuta 
Published: February 2021

Este trabalho abrangeu um relato de caso em conjunto com uma revisão sistemática da literatura, sobre a Cardiomiopatia de Takotsubo (CT). Essa doença é reconhecida como uma síndrome cardíaca aguda, cuja apresentação clínica assemelha-se ao infarto agudo do miocárdio (IAM). A condição afeta, predominantemente, mulheres e é geralmente precedida de estresse emocional ou físico, podendo apresentar diferentes variantes, dentre elas a invertida. Tem-se proposto que a patogênese da síndrome de takotsubo pode se apresentar por diferentes mecanismos fisiopatológicos, dentre eles a isquemia miocárdica, a obstrução do trato de saída do ventrículo esquerdo, a toxicidade miocárdica de catecolaminas e a disfunção do sistema nervoso autônomo. A CT geralmente é reversível, mas, durante a fase aguda, um número substancial de pacientes desenvolve complicações graves, como arritmias, insuficiência cardíaca incluindo edema pulmonar e cardiogênico, choque, tromboembolismo, parada cardíaca e ruptura. O trabalho teve como finalidade contribuir para a melhor compreensão da CT e seu tratamento, além de demonstrar casos já existentes de uma variante invertida. Concluiu-se que é fundamental para um melhor prognóstico e prevenção de recidivas, após a exclusão do diagnóstico de IAM, o tratamento de fatores precipitantes, doenças predisponentes e complicações é fundamental durante a fase aguda da doença, bem como após a melhora das condições do paciente. Isso se verifica principalmente em mulheres na perimenopausa, nas quais a incidência de recorrência é substancialmente maior.
Outcome of COVID-19 and Match-Population Analysis with Compassionate Use of Remdesivir
Authors: Vasylyeva Olga , Chen Tara , Hanna John 
Published: February 2021

Abstract: Objectives: To analyze treatment outcomes for patients with COVID-19 with and without compassionate use of Remdesivir.
Methods: A retrospective review of electronic medical records for patients who did not receive Remdesivir due to unavailability. Match-population analysis based on inclusion criteria for compassionate use Remdesivir of the patient population who received Remdesivir as reported in literature and patients without Remdesivir.
Results: Sixty-six percent of patients met the criteria for compassionate use Remdesivir, 41% required intensive care unit admission, 20% invasive ventilation, and 10% died. The median time of hospitalization for survivors was eight days.
In the separate group of patients who did not meet the criteria for compassion use Remdesivir, mortality among patients with CrCl > 30 ml min, an exclusion criterion, was significantly higher as compared with patients with CrCl < 30 ml min.
Conclusion: When compared with previously reported data from patients who received compassionate use Remdesivir, our population had notably fewer patients requiring invasive ventilation.
Late-Onset Psychiatric Manifestations Revealing Limbic Encephalitis: a Case Report of a 48 Years Old Man
Authors: Regaya Meriem , Amamou Badii , Ben Haouala Amjed , Mhalla Ahmed , Zaafrane Ferid , Gaha Lotfi 
Published: February 2021

Psychiatric symptoms of late-onset are often atypical and an organic origin that remains to be eliminated at first. Still, many somatic etiologies like encephalitis remains poorly understood and multidisciplinary management is necessary.
We present the case of a man hospitalized for the first time in the psychiatric ward of Monastir Tunisia at the age of 48 for behavioral disorders with atypical symptoms, Brain Magnetic resonance imaging showed bilateral signal abnormalities of the internal temporal region and hippocampal left lesions, suggestive of encephalitis. The autoimmune origin has been strongly suspected and the determination of "onco-neuronal" antibodies and specifically the assay of anti Ma1 and anti Ma2 antibodies were positive. These elements lead us to evoke autoimmune encephalitis and immunotherapy was initiated for the patient.
International Migration
Authors: Jímenez Everardo Víctor , Zamora Neyda del Rosario , Zamir Urcuyo Axel 
Published: February 2021

This work shows how the absence of parents due to migration affects students learnin, for that reason a sample of 993 students with a 95% confidence and 3% margin of error was considereted . This study is qualitative and quantitative in nature. Among the main results found is that 19.4% of surveyed students saffer abscence of mother, father or both of them due to migration. In addition it was also observed that the most direct consequences are feeling of loss, sodness académic performance and behaviour.
Utilizing integrative taxonomy uncovers a new stygobiotic Caridina species (Decapoda: Caridea: Atyidae) from Guizhou Province, China
Authors: Feng Shuo , Chen Qing-Hua , Guo Zhao-Liang 
Published: February 2021

Collecting much-needed information on the taxonomy, distribution, and ecology of cave-dwelling shrimp is the foundation for addressing urgent challenges in conservation biodiversity and these fragile ecosystems. Caridina unicolor sp. nov., a new atyid shrimp from an underground stream of Yaoshui Cave, Daqikong scenic area, Libo County, Guizhou Province, southwestern China is described based on morphology and DNA analysis (mitochondrial COI). Caridina unicolor sp. nov. differs from epigean congeners by the variable eye, ranging from reduced to blind; colorless body and appendages; the long stylocerite and sixth abdominal segment; and relatively large eggs. In comparison to other cave species, Caridina unicolor sp. nov. presents a long rostrum and stylocerite; the slender sixth abdominal segment; and the unique shape of appendix masculina. The data on the habitat, ecology, and the levels of threat are provided and suggest that it be categorized as Critically Endangered (CR).
Du stress au flow : le coping comme variable intermédiaire
Authors: Ben Sedrine Doghri Sinda , Bouderbala Amel , Ben Hamouda Melek 
Published: February 2021

L’objet de cet article est l’étude du stress dans une approche transactionnelle mettant en jeu d’une part le stress perçu par l’individu, au centre la variable intermédiaire de coping (le faire face au stress) et d’autre part le flow (bien-être). L’objectif est d’expliquer le lien entre le stress perçu et la stratégie de coping centrée sur la résolution de problèmes ainsi que le lien entre le coping et le flow susceptible d’être atteint par un individu. Les résultats soutiennent que le contrôle perçu, est positivement lié au coping. Un lien significatif et négatif existe entre la perception de débordement et le coping. Le coping impacte positivement et d’une manière significative les trois dimensions du flow. Ces résultats se joignent aux travaux menés par Folkman, 1982, 1984 ; Koeske et al ., 1993 ; Lazarus, 1993 ainsi que Bruchon-Schweitzer et Dantzer, 1994, qui font apparaître les stratégies centrées sur le problème comme des stratégies efficaces permettant le passage d’un état de stress vers un état de flow.
Entre mission et marché : la diversité, enjeu stratégique des grandes écoles de management françaises ?
Authors: Meyer Maryline , Joly Cédrine , Jaeck Mélanie , Marais Magalie 
Published: February 2021

Cet article propose d’analyser les politiques de diversité mises en place par les Grandes Ecoles de management (business schools ) françaises dans une dimension stratégique et se focalise plus spécifiquement sur les écoles de milieu classement, fortement soumises à des enjeux de concurrence et de différentiation sur leurs marchés. Nous explorons dans quelle mesure une politique de diversité peut permettre de concilier les logiques économique et sociale de ces organisations hybrides. A partir d’une étude qualitative exploratoire réalisée auprès de sept Grandes Ecoles de management, nous mettons en évidence les orientations actuellement prises par les politiques de diversité des business schools et la manière dont ces politiques articulent des logiques institutionnelles multiples. Nos résultats concluent à une appropriation à géométrie variable par les business schools étudiées de la diversité et de ses enjeux associés qui dépendrait de l’engagement des dirigeants et de la gouvernance sur ces questions. Nous montrons que pour les écoles ayant intégré la diversité à leur mission et à leur stratégie, la réconciliation entre les logiques économique et sociale passe par le renforcement de la réputation et de l’attractivité de ces écoles, par la réponse à la recherche de sens des étudiants mais aussi à l’amélioration de l’insertion professionnelle de ces derniers. Deux tensions associées à la combinaison de ces logiques ressortent par ailleurs de nos cas : une tension entre la diversité et l’excellence académique, d’une part, et une tension entre la diversité et la rentabilité économique, d’autre part.
La synonymie dans les reformulations à l’oral et à l’écrit spontanés
Authors: Eshkol-Taravella Iris 
Published: February 2021

Cette étude met au centre de ses recherches des données authentiques où la synonymie se produit d’une manière spontanée. La démarche se situe dans le domaine de la linguistique de corpus. Son objectif est d’étudier la synonymie prise au sens large dans les reformulations introduites à l’aide de trois marqueurs, c’est-à-dire , je veux dire , disons , et réalisées dans deux corpus : des entretiens oraux transcrits et des discussions en ligne issues d’un forum. La synonymie est vue ici de différents points de vue : l’utilisation des marqueurs de reformulation paraphrastique, l’apparition de synonymes dans les deux segments reformulés et, enfin, à travers la notion de paraphrase considérée dans ce travail comme un sous-type de reformulation.
The boundary between “Judaism” and “Aryanism”: Anti-Semitic logic, litigation, and bureaucratic practices relating to the classification of “half-Jews” in Occupied France (1940-1944)
Authors: Joly Laurent 
Published: February 2021

Under the Occupation, the French Jewish Statute made no provisions for an intermediary status for individuals of mixed heritage (who the administration called “half-Jews”), to the contrary of Nazi legislation in Germany. Consequently, there were no first- or second-degree mixed-heritage people in France; one was either Jewish or not. But the criteria for defining whether or not “half-Jews” were of “the Jewish race” varied between German and French texts, case law, and the practices of specialized bureaucrats. The boundary between “Jewish” and “non-Jewish” was tenuous, often arbitrary, and shaped by religious affiliation, a divorce, a marriage, or other fact of life. Being classified on the “good” or “bad” side of the “barricade” (according to the formulation of George Montandon, the ethno-racial expert of the Paris Prefecture of Police and the Commissariat-General for Jewish Affairs [CGQJ]) was very often a matter of life or death. The administration (mainly the “Jewish Service” of the Prefecture of Police and the CGQJ) and the courts had to rule on thousands of “ambiguous cases.” The CGQJ delivered over 11,000 “Certificates of Non-Belonging to the Jewish Race” after painstaking investigations. This article considers the categories that agents of the State used to sort out these borderline cases, and tries to understand the root causes of this dogged quest to determine the legal and political boundary between “Jew” and “non-Jew.”
Self-Regulated Learning in Students of the Faculty of Medicine and Surgery, Southeast Regional University (Oaxaca, Mexico)
Authors: García-Montalvo I. A. 
Published: February 2021

Introduction: Self-regulated learning is identified as an active, independent, autonomous, critical, adaptive, reflective and strategic process, to achieve comprehensive training, continuous selfimprovement, self-determination, autonomy and update itself permanently. The objective of this work is to analyze the self-regulation strategies of undergraduate students assigned to the Faculty of Medicine and Surgery of the Southeast Regional University for the 2019-2020 school year. Methodology: This is a descriptive-cross-sectional study, the sample was obtained through a simple random sampling among students from first to fifth year, with substitution of exclusion elements, the instrument used was the adapted Torre questionnaire (2016) and validated for this study. Results: Study subjects demonstrated adequate metacognitive awareness, control and verification, in addition to having active processing during classes, however, they present little effort in performing tasks, which leads us to establish recommendations for the educational practice that reinforces above all the teaching of these strategies in the university environment of health sciences. Conclusion: The undergraduate students of the Faculty of Medicine and Surgery of the Southeast Regional University are clear about what self-regulated learning is mainly in students of more advanced years or who have already begun to contact the clinical area, unlike the students of the first years where behavioral strategies are still perceived.
Primary Healthcare Strengthening through Distance Education for Health Professionals
Authors: Karunathilake I. M. , Bandara J. , Attygalle D. , Gunawardena C. N. , Egodage T. , Chandrasena U. 
Published: February 2021

Introduction: Primary Health Care is proven to be a highly effective and efficient way to address poor health and well-being. Despite its achievements Sri Lanka’s PHC System, specialized for preventive and curative actions, is increasingly under pressure due to chronic and non-communicable diseases. Developing the broad range of skills necessary for medical practice in the existing PHC settings should be achieved through continuous professional development. A distant learning programme through eLearning is a model solution to expand the existing boundaries for CPD. Methods: Sri Lanka Medical Association, Ministry of Health, Primary Healthcare System Strengthening Project and World Bank have collaboratively worked as key stakeholders to develop and implement a course for capacity building among the medical professionals. The first phase of the course was developed with 6 priority modules consisting of Ministry of Health approved content conjoined with digital material. Participants were provided with additional resources. The course was evaluated by assessing user involvement and users’ perception towards the course. The course reflected a positive involvement for majority of modules and a generally positive feedback despite the response rate being considerably low. Discussion: Vulnerabilities in the system could be identified including shortcomings of the system, instructors and learning material, and administration issues. Including diverse course materials, provision of incentives for participation, training resource persons and other recommendations may allow better distance learning experience with desired outcomes. Conclusion: Distance learning through an eLearning platform is an ideal way to address CPD in PHC through timely modules, appropriate learning material, user friendly interface, efficient evaluation methods, and an effective system improving procedure. This course has enabled medical professional to develop their insights in PHC, however the shortcomings should not be neglected.
TSC1 Suppresses Macrophage Necroptosis for the Control of Infection by Fungal Pathogen Candida albicans
Authors: Li Tiantian , Xie Yadong , Shi Lei , Sun Yumeng , Wen Jing , Deng Zihou , Zhang Haibing , Li Huabin , Yang Jinbo , Xiao Hui 
Published: February 2021

Abstract
Candida albicans is the most common, opportunistic human fungal pathogen whose complex interplay with the host innate immune system remains incompletely understood. In this study, we revealed that infection macrophages with C. albicans triggers prominent cell death, which is largely attributed to the RIPK3/MLKL–mediated necroptosis. Our results further demonstrated that the TSC1-mTOR pathway plays a pivotal role in the control of macrophage necroptosis upon engaging the Dectin-1/2 and TLR-2/4 pathways through fungal components β-glucan/α-mannan or Sel1, respectively. Notably, the rapamycin-sensitive mTORC1 pathway, rather than the rapamycin-insensitive mTORC2 pathway, was responsible for elevated activation of RIPK1, RIPK3, and MLKL in TSC1-deficient macrophages. Following systemic infection with C. albicans, mice with macrophage/neutrophil–specific deletion of Tsc1 (Tsc1M/N−/−) showed heightened fungal burden in multiple organs, such as the kidney, liver, and spleen, severe morbidity, and mortality. Notably, Tsc1M/N−/− kidneys exhibited prominent cell death and concomitant loss of tissue-resident macrophages, which likely contributing to a dampened phagocytosis of fungal pathogens. Together, our data demonstrate a crucial role for the TSC1-mTOR pathway in the regulation of macrophage necroptosis and suggest that both Dectin- and TLRs-induced necroptosis may undermine the immune defense effector functions of these innate receptors during C. albicans infection.
Reliability and validity of the Chinese version of the vitiligo specific quality of life instrument (VitiQoL)
Authors: Zhao Hui , Zhao Na , Zhou Bingni , Chen Guo , Wang Yaru , Zhang Huimin , Lin Yan , Liu Huaxu , Kundu Roopal V. , Yang Baoqi 
Published: February 2021

Background:
Vitiligo is an acquired, idiopathic skin disorder that can significantly affect the health-related quality of life (QoL). The vitiligo-specific QoL instrument (VitiQoL), recently developed by an American group, was found to be a reliable patient-reported outcome measure in both Brazilian and Iranian patients.

Methods:
The VitiQoL was initially cross-culturally adapted to Chinese through forward-backward translation. The Chinese version of the VitiQoL was then distributed to 182 vitiligo patients together with the dermatology life quality index (DLQI) and Skindex-16 questionnaire. Then, the reliability and validity of the Chinese version of the VitiQoL was assessed by statistical analysis.

Results:
The Chinese version of the VitiQoL showed high internal consistency (Cronbach alpha = 0.958) and test–retest reliability (intraclass correlation coefficient = 0.887). Convergent validity testing showed that the correlation coefficient for the Chinese VitiQoL and DLQI was 0.70 (P < 0.01), the Chinese VitiQoL and Skindex-16 each was 0.84 (P < 0.01), and for the Chinese VitiQoL (questions 1–15 and 16) was 0.62 (P < 0.01). Confirmatory factor analysis revealed two important factors within the VitiQoL: Participation limitation and stigma.

Conclusion:
The Chinese version of the VitiQoL questionnaire has sufficient reliability and validity to be used to evaluate Chinese vitiligo patients' QoL.
Impact of COVID-19 pandemic and national lockdown on ocular trauma at a tertiary eye care institute
Authors: Agrawal Deepanshu , Parchand Swapnil , Agrawal Deepshikha , Chatterjee Samrat , Gangwe Anil , Mishra Mihir , Sahu Anupam 
Published: February 2021

Purpose:
To evaluate the impact of the COVID-19 pandemic and the national lockdown on the demographic and clinical profile of patients presenting with ocular trauma.

Methods:
In this retrospective, hospital-based, comparative analysis, patients presenting to the emergency department with ocular trauma in the following COVID-19 period (March 25, 2020 to July 31, 2020) were compared with patients in the pre-COVID-19 period (March 25, 2019 to July 31, 2019).

Results:
Overall, 242 patients (COVID-19 period: 71 and pre-COVID-19 period: 171) presented with ocular trauma. The mean age of the patients in COVID-19 and pre-COVID-19 periods were 26.7 ± 17.3 and 34.1 ± 20.3 years, respectively (P = 0.008). A majority of patients (68.6%) in both groups were from the rural background. Home-related injuries were common in the COVID-19 period (78.8%) as compared to pre-COVID-19 period (36.4%) (P < 0.0001). Iron particles (29.5%) were the common inflicting agents in the COVID-19 period while it was plant leaves (25.5%) in the pre-COVID-19 period. The most common ocular diagnosis was open globe injury (40.8%) in the COVID-19 period and microbial keratitis (47.9%) in the pre-COVID-19 period. Surgical intervention was required in 46.4% of patients in the COVID-19 period and 32.1% of patients in the pre-COVID-19 period (P = 0.034).

Conclusion:
During the COVID-19 period, there was a significant decline in the number of patients presenting with ocular trauma. In this period, a majority of patients sustained ocular trauma in home-settings. About half the patients required surgical intervention which was most commonly rendered in the form of primary wound repair.
GPT3: DALL-E VE JL2P EKSENİNDE VERİ GÖRSELLEŞTİRME VE HAREKETLENDİRME ÜZERİNE BİR İNCELEME
Authors: ŞEN Ezgi 
Published: February 2021

Teknolojik evrimin güçlü sembollerinden biri olan yapay zekâ, derin öğrenme alanındaki güncel gelişmeler doğrultusunda hızla ilerleme kaydetmektedir. Bu ilerlemenin somut çıktılarından biri olan GPT3 sistemi (üretici ön-eğitimli dönüştürücü-generative pre-trained transformer3) derin öğrenme dil modeline bağlı olarak, veri görselleştirme alanında hızla gelişmektedir. OpenAI tarafından geliştirilen GPT3'ün bir ürünü olan Dall-e, doğal dilde ifade edilen metinleri görüntüye dönüştüren yapay bir sinir ağıdır. Dall'e 12 milyar civarında parametrenin anlamını tanıyarak kendisine verilen cümleleri daha önce hiç yapılmamış görsellere dönüştürebilmektedir. Dall-e sistemine benzer bir şekilde çalışan bir diğer sistem ise, JL2P (Joint Language to Pose) olarak adlandırılan doğal dile dayalı poz tahmini çalışmasıdır. JL2P uygulamasında tıpkı Dall-e de olduğu gibi yazı temelli bir aksiyon söz konusudur. Bu sistemde verilen sözel girdiye göre ilgili karakter, kendisinden istenen hareketi görsel olarak gerçekleştirebilmektedir. Bu durum animasyon ve oyun tasarımı alanında sadece sözel ifadeler üzerinden karakter görselleştirmelerinin ve hareketlerinin kolaylıkla yapılabileceğini göstermektedir. Bu makale, yapay zekânın veri görselleştirme ve hareketlendirme becerilerinin getirmiş olduğu güncel gelişmeleri, disiplinler arası bir bakış açısıyla okuyucuya aktarmayı amaçlamaktadır. Yapay zekâ ve veri görselleştirme alanındaki çalışmalar, tasarımcıların hikaye panosu (storyboard) oluştururken ya da beyin fırtınası (brainstorming) yaparken ilham almalarını sağlayabilecek bir sistemin kapılarını aralamaktadır. Bu alanda yapılan araştırmalar, tasarımcı ve yapay zekâ ilişkisinin yaratıcılık, üretkenlik, hız gibi kavramlar üzerinden değerlendirilmesi adına önemlidir.