bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in emotions and worries during the Covid-19 pandemic: an online-survey with children and adults with and without mental health conditions
Authors: Rothe Josefine , Buse Judith , Uhlmann Anne , Bluschke Annet , Roessner Veit 
Published: February 2021

Abstract
Background
The novel coronavirus disease (Covid-19) has spread quickly worldwide with dramatic consequences on our daily lives. Adverse psychosocial consequences of Covid-19 might be particularly severe for children and adolescents, parents of young children and people with mental health conditions (mhc), who are more prone to the experience of psychosocial stress and who are more dependent on the access to professional psychosocial support. The present survey therefore aimed to explore perceived stress and the emotional responses of children and adolescents as well as adults with and without mhc during the social restrictions due to the Covid-19 pandemic.

Methods
The survey gathered information about 284 children and adolescent (parent-on-child-reports) and 456 adults (including 284 parents, self-reports). The participants were allocated to four groups: children and adolescents with mhc, children and adolescent without mhc, adults with mhc and adults without mhc. The survey included general questions about socio-demographic characteristics and mental health status, the CoRonavIruSHealth Impact Survey and the Perceived Stress Scale (only data on adults). Wilcoxon signed-rank tests were used for comparing the emotional responses during the Covid-19 pandemic with emotions before the Covid-19 pandemic. Independent sample t-test were used to compare the level of perceived stress between the adult groups, linear regression analyses were conducted to examine which variables predicted perceived stress during the Covid-19 restrictions.

Results
An increase to the worse during the Covid-19 restrictions was observed for most emotions and worries in all four groups (children and adolescents with mhc, children and adolescents without mhc, adults with mhc, adults without mhc). Contrary to our expectations, a greater number of emotions worsened significantly for children and adolescents as well as adults without mhc as compared to those with mhc. We found higher perceived stress in parents as compared to adults without children in the same household and in adults with mhc as compared to those without mhc.

Discussion
Covid-19-related social restrictions and potential health risks seem to affect emotions and perceived stress in children, adolescents and adults. Especially, Covid-19 seems to be have worsened the mental well-being of children and adolescent and their families, who were mentally healthy before the Covid-19 pandemic.
Infected thoracoabdominal aortic aneurysm related to an implanted long-term arterial catheter for chemotherapy: a case report
Authors: Takemoto Kiyoshi , Nakamura Michitaka , Sakuraya Masaaki , Yamamoto Tomonori , Iwanaga Wataru , Atagi Kazuaki , Yamanaka Kazuo , Matsuyama Takeshi 
Published: February 2021

Abstract
Background
An infected aortic aneurysm is a rare and life-threatening vascular condition with a high incidence of arterial rupture and recurrence even after treatment. One of the most common causes of an infected aortic aneurysm is catheter-related bloodstream infection. Although infection due to indwelling catheters is possible, the incidence of this is rare, especially for long-term implanted arterial catheters.

Case presentation
A 78-year-old Japanese man with a past medical history of rectal cancer with metastasis to the liver presented to our hospital as a result of low back pain. Remission had been achieved following surgery and adjuvant chemotherapy via an implanted catheter for arterial infusion. However, the original catheter that was inserted from the femoral artery to the hepatic artery via the celiac artery was still present more than 10 years after diagnosis, without being replaced, in case of a recurrence. On the day of admission, computed tomography scan of the chest and abdomen with contrast revealed an irregularly shaped aortic aneurysm at the origin of the celiac artery and a partially expanded common hepatic artery with disproportionate fat stranding along the implanted arterial catheter without extravasation. Although the initial impression was an impending rupture of the acute thoracoabdominal aortic aneurysm, a catheter-related infection was considered as a differential diagnosis. Surgery was performed, which revealed a catheter-related infected aortic aneurysm based on images along the catheter, pus cultures, and tissue pathology examination results.

Conclusions
This is an extremely rare case of an infectious aneurysm caused by prolonged implantation of an arterial catheter for chemotherapy. It should be noted that an indwelling arterial catheter not only causes bloodstream infections but can also cause an infection of a thoracoabdominal aortic aneurysm.
Stand structure and species diversity regulate biomass carbon stock under major Central Himalayan forest types of India
Authors: Kaushal Siddhartha , Baishya Ratul 
Published: February 2021

AbstractBackgroundData on the impact of species diversity on biomass in the Central Himalayas, along with stand structural attributes is sparse and inconsistent. Moreover, few studies in the region have related population structure and the influence of large trees on biomass. Such data is crucial for maintaining Himalayan biodiversity and carbon stock. Therefore, we investigated these relationships in major Central Himalayan forest types using non-destructive methodologies to determine key factors and underlying mechanisms.ResultsTropicalShorea robustadominant forest has the highest total biomass density (1280.79 Mg ha−1) and total carbon density (577.77 Mg C ha−1) along with the highest total species richness (21 species). The stem density ranged between 153 and 457 trees ha−1with large trees (> 70 cm diameter) contributing 0–22%. Conifer dominant forest types had higher median diameter andCedrus deodaraforest had the highest growing stock (718.87 m3ha−1); furthermore,C.deodaracontributed maximally toward total carbon density (14.6%) among all the 53 species combined.Quercus semecarpifolia–Rhododendron arboreumassociation forest had the highest total basal area (94.75 m2ha−1). We found large trees to contribute up to 65% of the growing stock. Nine percent of the species contributed more than 50% of the carbon stock. Species dominance regulated the growing stock significantly (R2 = 0.707,p< 0.001). Temperate forest types had heterogeneous biomass distribution within the forest stands. We found total basal area, large tree density, maximum diameter, species richness, and species diversity as the predominant variables with a significant positive influence on biomass carbon stock. Both structural attributes and diversity influenced the ordination of study sites under PCA analysis. Elevation showed no significant correlation with either biomass or species diversity components.ConclusionsThe results suggest biomass hyperdominance with both selection effects and niche complementarity to play a complex mechanism in enhancing Central Himalayan biomass carbon stock. Major climax forests are in an alarming state regarding future carbon security. Large trees and selective species act as key regulators of biomass stocks; however, species diversity also has a positive influence and should also reflect under management implications.
Occupation-specific wage returns: shedding light on differentials between employees with a VET degree either with or without an Abitur
Authors: Friedrich Anett , Hirtz Sandra 
Published: February 2021

AbstractThis study seeks to reveal the heterogeneity in occupation-specific wage returns among graduates of the German vocational education and training (VET) system. We distinguish between VET graduates with and without a higher education entrance certificate (i.e. an Abitur). To implement our hierarchical multi-level analyses, we exploit the latest wave of the BIBB/BAuA Employment Survey from 2018. By estimating occupation-specific wage returns, we reveal gaps between VET graduates with and without an Abitur. Additionally, we analyse several occupational characteristics to show how they contribute to the gaps in wage returns between our study groups. Our results show that employees combining an Abitur with a VET degree achieve higher wage returns than those VET graduates without an Abitur across all occupations. Employees holding a VET degree without an Abitur display greater inequality of occupation-specific wage returns. Among the occupational characteristics, task composition is the main driver of the differences in wage returns.
Identification of an anti-plant-virus molecule in Alpinia zerumbet
Authors: Hatanaka Tadashi , Narusaka Mari , Uraji Misugi , Yamaji Yasuyuki , Narusaka Yoshihiro 
Published: February 2021

AbstractIn plants, viral diseases are second only to fungal diseases in terms of occurrence, and cause substantial damage to agricultural crops. The aqueous extracts of shell ginger,Alpinia zerumbetexhibit inhibitory effects against virus infections in belonging to the Solanaceae family. In this study, we isolated an anti-plant-virus molecule from the extracts using a conventional method involving a combination of reversed phase column chromatography, dialysis, and lyophilization. The anti-plant-virus molecule was identified as proanthocyanidin, which mostly consisted of epicatechin and exhibited more than 40 degrees of polymerization.
A High Proportion of Novel ACAN Mutations and Their Prevalence in a Large Cohort of Chinese Short Stature Children
Authors: Lin Li , Li Mengting , Luo Jingsi , Li Pin , Zhou Shasha , Yang Yu , Chen Ka , Weng Ying , Ge Xiuying , Mireguli Maimaiti , Wei Haiyan , Yang Haihua , Li Guimei , Sun Yan , Cui Lanwei , Zhang Shulin , Chen Jing , Zeng Guozhang , Xu Lijun , Luo Xiaoping , Shen Yiping 
Published: February 2021

Abstract

Context
Aggrecan, encoded by the ACAN gene, is the main proteoglycan component in the extracellular cartilage matrix. Heterozygous mutations in ACAN have been reported to cause idiopathic short stature. However, the prevalence of ACAN pathogenic variants in Chinese short stature patients and clinical phenotypes remain to be evaluated.

Objective
We sought to determine the prevalence of ACAN pathogenic variants among Chinese short stature children and characterize the phenotypic spectrum and their responses to growth hormone therapies.

Patients and Methods
Over 1000 unrelated short stature patients ascertained across China were genetically evaluated by next-generation sequencing–based test.

Result
We identified 10 novel likely pathogenic variants and 2 recurrent pathogenic variants in this cohort. None of ACAN mutation carriers exhibited significant dysmorphic features or skeletal abnormities. The prevalence of ACAN defect is estimated to be 1.2% in the whole cohort; it increased to 14.3% among those with advanced bone age and to 35.7% among those with both advanced bone age and family history of short stature. Nonetheless, 5 of 11 ACAN mutation carries had no advanced bone age. Two individuals received growth hormone therapy with variable levels of height SD score improvement.

Conclusion
Our data suggest that ACAN mutation is 1 of the common causes of Chinese pediatric short stature. Although it has a higher detection rate among short stature patients with advanced bone age and family history, part of affected probands presented with delayed bone age in Chinese short stature population. The growth hormone treatment was moderately effective for both individuals.
Insulin Pulse Characteristics and Insulin Action in Non-diabetic Humans
Authors: Laurenti Marcello C , Dalla Man Chiara , Varghese Ron T , Andrews James C , Jones John G , Barosa Cristina , Rizza Robert A , Matveyenko Aleksey , De Nicolao Giuseppe , Bailey Kent R , Cobelli Claudio , Vella Adrian 
Published: February 2021

Abstract

Objective
Pulsatile insulin secretion is impaired in diseases such as type 2 diabetes that are characterized by insulin resistance. This has led to the suggestion that changes in insulin pulsatility directly impair insulin signaling. We sought to examine the effects of pulse characteristics on insulin action in humans, hypothesizing that a decrease in pulse amplitude or frequency is associated with impaired hepatic insulin action.

Methods
We studied 29 nondiabetic subjects on two occasions. On 1 occasion, hepatic and peripheral insulin action was measured using a euglycemic clamp. The deuterated water method was used to estimate the contribution of gluconeogenesis to endogenous glucose production. On a separate study day, we utilized nonparametric stochastic deconvolution of frequently sampled peripheral C-peptide concentrations during fasting to reconstruct portal insulin secretion. In addition to measuring basal and pulsatile insulin secretion, we used approximate entropy to measure orderliness and Fourier transform to measure the average, and the dispersion of, insulin pulse frequencies.

Results
In univariate analysis, basal insulin secretion (R2 = 0.16) and insulin pulse amplitude (R2 = 0.09) correlated weakly with insulin-induced suppression of gluconeogenesis. However, after adjustment for age, sex, and weight, these associations were no longer significant. The other pulse characteristics also did not correlate with the ability of insulin to suppress endogenous glucose production (and gluconeogenesis) or to stimulate glucose disappearance.

Conclusions
Overall, our data demonstrate that insulin pulse characteristics, considered independently of other factors, do not correlate with measures of hepatic and peripheral insulin sensitivity in nondiabetic humans.
The Effect of Low-Dose Intraoperative Ketamine on Closed-Loop-Controlled General Anesthesia: A Randomized Controlled Equivalence Trial
Authors: Napoleone Gabby , van Heusden Klaske , Cooke Erin , West Nicholas , Görges Matthias , Dumont Guy A. , Ansermino J. Mark , Merchant Richard N. 
Published: February 2021

BACKGROUND:
Closed-loop control of propofol-remifentanil anesthesia using the processed electroencephalography depth-of-hypnosis index provided by the NeuroSENSE monitor (WAVCNS) has been previously described. The purpose of this placebo-controlled study was to evaluate the performance (percentage time within ±10 units of the setpoint during the maintenance of anesthesia) of a closed-loop propofol-remifentanil controller during induction and maintenance of anesthesia in the presence of a low dose of ketamine.

METHODS:
Following ethical approval and informed consent, American Society of Anesthesiologist (ASA) physical status I–II patients aged 19–54 years, scheduled for elective orthopedic surgery requiring general anesthesia for >60 minutes duration, were enrolled in a double-blind randomized, placebo-controlled, 2-group equivalence trial. Immediately before induction of anesthesia, participants in the ketamine group received a 0.25 mg·kg−1 bolus of intravenous ketamine over 60 seconds followed by a continuous 5 µg·kg−1·min−1 infusion for up to 45 minutes. Participants in the control group received an equivalent volume of normal saline. After the initial study drug bolus, closed-loop induction of anesthesia was initiated; propofol and remifentanil remained under closed-loop control until the anesthetic was tapered and turned off at the anesthesiologist’s discretion. An equivalence range of ±8.99% was assumed for comparing controller performance.

RESULTS:
Sixty patients participated: 41 males, 54 ASA physical status I, with a median (interquartile range [IQR]) age of 29 [23, 38] years and weight of 82 [71, 93] kg. Complete data were available from 29 cases in the ketamine group and 27 in the control group. Percentage time within ±10 units of the WAVCNS setpoint was median [IQR] 86.6% [79.7, 90.2] in the ketamine group and 86.4% [76.5, 89.8] in the control group (median difference, 1.0%; 95% confidence interval [CI] −3.6 to 5.0). Mean propofol dose during maintenance of anesthesia for the ketamine group was higher than for the control group (median difference, 24.9 µg·kg−1·min−1; 95% CI, 6.5-43.1; P = .005).

CONCLUSIONS:
Because the 95% CI of the difference in controller performance lies entirely within the a priori equivalence range, we infer that this analgesic dose of ketamine did not alter controller performance. Further study is required to confirm the finding that mean propofol dosing was higher in the ketamine group, and to investigate the implication that this dose of ketamine may have affected the WAVCNS.
Ladrones de Luz: Policing Electricity in Mexico City, 1901–1918
Authors: Montaño Diana J. 
Published: February 2021

AbstractThis essay explores Mexico City's electrification in the early twentieth century through the lens of power theft. The arrest and resulting trial of dozens of capitalinos (Mexico City residents) suspected of power theft allow us to document the nuances of policing and prosecuting a modern crime and thus to explore how notions of policing, private property, space, honor, and even decency influenced how people secured and used electricity. Using 63 cases tried before the Tribunal Superior de Justicia del Distrito Federal (Federal District Higher Court) and newspaper and legal debate on power theft, this article examines how capitalinos could flip seamlessly between the elitist, scripted, proper use of electricity and the ad-libbed, improper use that fit their needs in specific circumstances. By grounding electrification in everyday life, this article argues that capitalinos emerge as agents of technological change, people who understood the importance of electricity to transform their lives and spaces.
Abdominal Organ Injuries in Youth Soccer: A Case Series and Review of Literature
Authors: Khakimov Sayyar , Zaki Peter , Hess Joseph , Hennrikus William 
Published: February 2021

Abstract
We describe 13 children who presented to the Penn State Health Milton S. Hershey Medical Center (HMC) with pediatric soccer-related abdominal organ injuries. A review of the Pennsylvania Trauma System Foundation's Trauma Registry was performed between 2001 and 2015 for children with soccer injuries hospitalized at trauma centers across Pennsylvania. Out of 52 children at Hershey Medical Center, 13 suffered abdominal organ injuries. Injuries included the spleen [5], kidney [4], liver [2], and combined organ involvement [2]. All patients presented with abdominal and/or flank pain. All patients with kidney injuries presented with hematuria. All patients presented after a player-to-player (P2P) contact. Nearly all patients (12/13) were treated nonsurgically. Our findings showed that abdominal organ injuries constitute a substantial portion of pediatric soccer injuries requiring hospitalization, with spleen being the organ injured most frequently. Soccer-related abdominal organ injuries should be suspected in players who suffer abdominal and/or flank pain, and/or hematuria after a P2P contact.
Creating an Assessment Tool for Clinical Musculoskeletal Knowledge
Authors: Yu Jonathan , Li Alexander D. , Leggit Jeffrey C. 
Published: February 2021

Abstract
Studies show that medical school curriculums do not prepare graduates to manage the most common musculoskeletal (MSK) injuries they will encounter in the outpatient setting. The authors proposed a new multiple-choice assessment to identify individual and program deficiencies for curriculum improvement. A multiple-choice MSK assessment tool was administered to learners at various stages of training. Students took the examination after completing their core clerkship year; residents took the examination near the beginning of their respective academic year. Outcome measures included average examination score, percent correct for each question, and overall examination reliability. Average examinees scores were 75.6% with higher scores based on training years. No statistical differences were found between MD/DO, male/female, or military/civilian examinees. The tool was found to be a statistically valid method of determining cognitive knowledge in basic MSK topics, identifying individual deficiencies, and highlighting gaps in training programs' MSK curriculums.
A Single Bout of Upper-Body Exercise Has No Effect on Postprandial Metabolism in Persons with Chronic Paraplegia
Authors: FARROW MATTHEW T. , MAHER JENNIFER L. , NIGHTINGALE TOM E. , THOMPSON DYLAN , BILZON JAMES L. J. 
Published: February 2021

ABSTRACT

Purpose
The acute effects of a single bout of upper-body exercise on postprandial metabolism in persons with spinal cord injury are currently not well understood. The primary aim of this study was to evaluate the effects of a single bout of upper-body high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE) in comparison with a no-exercise control (REST) condition on postprandial metabolic responses in persons with chronic paraplegia.

Methods
Ten participants (eight males, two females; age, 49 ± 10 yr; time since injury, 22 ± 13 yr) with chronic paraplegia took part in a randomized crossover study, consisting of three trials: HIIE (8 × 60 s at 70% peak power output [PPEAK]), MICE (25 min at 45% PPEAK), and REST, at least 3 d apart. Exercise was performed in the fasted state, and participants consumed a mixed-macronutrient liquid meal 1-h postexercise. Venous blood and expired gas samples were collected at regular intervals for 6-h postmeal consumption.

Results
There were no significant differences in postprandial incremental area under the curve for triglycerides (P = 0.59) or glucose (P = 0.56) between conditions. Insulin incremental area under the curve tended to be lower after MICE (135 ± 85 nmol·L−1 per 360 min) compared with REST (162 ± 93 nmol·L−1 per 360 min), but this did not reach statistical significance (P = 0.06, d = 0.30). Participants reported a greater fondness (P = 0.04) and preference for HIIE over MICE.

Conclusions
After an overnight fast, a single bout of upper-body exercise before eating has no effect on postprandial metabolism in persons with chronic paraplegia, irrespective of exercise intensity. This suggests that alternative exercise strategies may be required to stimulate postprandial substrate oxidation for this population.
MRI-based Measurement of Effects of Strength Training on Intramuscular Fat in People with and without Spinal Cord Injury
Authors: BOLSTERLEE BART , BYE ELIZABETH A. , EGUCHI JUNYA , THOM JEANETTE , HERBERT ROBERT D. 
Published: February 2021

ABSTRACT

Introduction
The accurate quantification of the proportion of fat in human muscles could help monitor disease status and test effectiveness of interventions in people with neurological conditions whose skeletal muscles are frequently infiltrated with fat.

Methods
We compared two commonly used magnetic resonance imaging methods to quantify fat in muscles. Measurements were obtained before and after 6 or 8 wk of strength training in a total of 116 muscles spanning the range of intramuscular fat proportions observed in able-bodied young adults and people with spinal cord injury.

Results
We successfully measured fat proportions in all muscles using the mDixon method but were unable to obtain plausible measurements with the T1-weighted method from muscles of able-bodied individuals or from the leaner 23% of muscles of people with spinal cord injury (muscles with less than approximately 8% fat). In muscles with more fat, measurements obtained with the two methods agreed well (intraclass correlation coefficient, 0.88; mean absolute difference, 5%). We also found that, compared with the T1-weighted method, the mDixon method provides a more detailed characterization of fat infiltration in muscle and a less variable measurement of the effect of training on the proportion of fat. The mDixon method showed that 6 or 8 wk of strength training did not appreciably change the proportion of intramuscular fat in either people with spinal cord injury or able-bodied people.

Conclusion
On the basis of these findings, we recommend the use of mDixon methods in preference to T1-weighted methods to determine the effectiveness of interventions aimed at reducing intramuscular fat.