bluuebunny/crossref_metadata_2025_split huggingface dataset:
ДІАГРАМИ, ГРАФІКИ ТА СХЕМИ ЯК ІНСТРУМЕНТАРІЙ ПРЕДСТАВЛЕННЯ ПРОЄКТНОЇ ІНФОРМАЦІЇ
Authors: Радкевич Олександр 
Published: October 2021

Актуальність: У проєктній діяльності необхідно оперувати великим масивом числових даних із різних проєктних завдань, що обтяжує комунікацію між виконавцями. Додає складності значна кількість проєктної інформації, що може бути неправильно поданою, а тому й незрозумілою для проєктних виконавців. Це створює комунікативні бар’єри, допоки доповідач не пояснить суть процесу, зобразивши діаграму, схему чи графік. З огляду на це, графічна подача інформації про проєкт, не замінюючи текстового представлення, є доцільною і значно пришвидшує розуміння принципів його виконання.
Мета: дослідити роль діаграм, графіків та схем як інструментарію представлення проєктної інформації.
Методи: теоретичний аналіз наукових джерел – для з’ясування стану дослідженості цієї проблематики в України та за її межами; порівняння – з метою вивчення наукових підходів до розв’язання проблеми; синтез прогресивного досвіду – для представлення проєктної інформації у вигляді діаграм, графіків та схем.
Результати: досліджено діаграму Ганта як гістограму для послідовного представлення інформації. Розкрито блок-схему, що ілюструє перебіг будь-якого процесу від загальної інформації до проєктних завдань. Висвітлено специфіку Кривої S, як для представлення базової чи фактичної кумулятивної вартості, так і порівняння цих двох показників у часі. Проаналізовано стовпчасту діаграму, що використовується для порівнянь та узагальнення груп даних. Розкрито характеристики ресурсної гістограми – для планування управління персоналом. Приділена увага діаграмі запуску, що використовується для управління якістю та відображає продуктивність представлення проєкту в часі.
Особлива увага приділена діаграмі Парето, згідно з якою забезпечується аналіз існуючих проблем у проєктній діяльності та прийняття рішень щодо контролю її якості. Проаналізовано секторну діаграму, яка використовується для показу вкладу окремих елементів у загальну суму проєкту. Контрольна діаграма – для перевірки стабільності будь-якого проєктного процесу як з контрольними межами, так і без них. Висвітлено основні складові організаційної схеми, що дає змогу зрозуміти організаційну ієрархію, рівні ескалації та шлях спілкування в проєкті.
Висновки: здійснений аналіз діаграм, графіків та схем як елементів проєктної комунікації засвідчив позитивний вплив графічної складової на комунікаційний процес
Study on Factors Affecting Physicochemical Properties of Spray Dried Mango Powder Using Taguchi Experimental Design Approach
Authors: Kongpichitchoke Teeradate , Gnoumou Edouard , Noomhorm Athapol , Ho-Hsien Chen 
Published: October 2021

Mango is a common fruit in tropical countries. Due to its short shelf-life, it is important to study alternative preservation and consumption methods. In this study, concentrated mango juice was used to produce mango powder by using spray drying process. Four process parameters with three levels variation each, including initial total soluble solid content (13, 14, 15◦Brix), maltodextrin content (20, 25, 30% w/w), inlet air temperature (170, 190, 210◦C), and atomization pressure (4, 5, 6 bar) were studied. Taguchi approach of L-9 (34) array was used to design the experiments. Powder yield, moisture content, color difference, and solubility of the mango powder were investigated. It was found that maltodextrin content was the greatest factor affecting powder yield and color difference. The highest powder yield was 31.81%, and the least color difference (∆E) was 3.17. Inlet air temperature and atomization pressure were the most important factor affecting to moisture content and solubility, respectively, in which average moisture content was 2.98% (w.b.) and the highest solubility value was 94.66%. For the overall production process, it was concluded that maltodextrin content was the most important parameter, while total soluble solid content provided the least impact on spray dried mango powder properties.
ЕМПІРИЧНЕ ДОСЛІДЖЕННЯ ОСОБЛИВОСТЕЙ ГРОМАДЯНСЬКОЇ ТА НАЦІОНАЛЬНОЇ САМОІДЕНТИФІКЦІЇ МОЛОДІ: БАЗОВІ ПОНЯТТЯ І ПОКАЗНИКИ
Authors: Zhadan I. V. 
Published: October 2021

У річищі конструктивно-дискурсивного підходу самоідентифікацію розглянуто як гнучкий дискурсивний конструкт, що постійно трансформується в процесі соціальної взаємодії і зміни психосоціального досвіду особи. З огляду на роль комунікації в розвитку ідентифікаційних процесів запропоновано класифікацію самоідентифікацій на основі способу знаково-символьної взаємодії особи з іншими та світом. Виокремлено чотири рівні самоідентифікації, кожному з яких відповідає певний спосіб використання знаку як засобу: а) позначення ідентичності, б) символічного її осмислення, в) конструювання категорій та ідеалів, з якими особа себе ідентифікує, г) конструювання умов і правил перетворення реальності. Операціоналізовано базові поняття: національну самоідентифікацію визначено як усвідомлення належності до політичної нації – соціокультурної спільноти, що має свій досвід державності, традиції, міфи і символіку, спільні цінності й очікування щодо майбутнього; громадянську – як самовизначення особистості в континуумі виявів суб’єктності та ототожнення із спільнотою, члени якої готові і здатні до обстоювання своїх інтересів у відповідальній, конструктивній соціальній взаємодії. Таким чином розмежовано ці поняття, визначено показники громадянської і національної самоідентифікації та висунуто припущення про особливості їх виявів на різних рівнях.
Penanggulangan Banjir/Genangan Dan Konservasi Air Tanah Dengan Pembuatan Sumur Resapan Di SMP Negeri 8 Menteng Jakarta Pusat
Authors: Putri Desi 
Published: October 2021

Jakarta is one of area that often experiences in flooding. Jakarta is increasingly vulnerable being affected due to the limited catchment area. Massive development with water tight surface conditions and limited water absorption caused by about 85% of rainfall falls in the Jakarta area. As a result of lack absorption in Jakarta, the amount of rain falling and flowing into the sea and rivers will increase. When the capacity of the river does not cover the river water automatically overflows it will cause flooding.
Mitra PKM is a junior high school building located in the Menteng area, Central Jakarta. In recent years the Mitra Area has overcome flooding disasters, the teaching and learning process in the Mitra region has being obstructed. The clean water crisis also occurs in the Mitra area, this is due to the location of the Mitra which is quite connected to office buildings that have a large enough need of clean water.
The average rainfall in Indonesia is 2779 mm per year, in Jakarta around 2500 mm per year, with a total of 180 rainy days/year. According to average rainfall, is the potentially of water resources and it can be utilized optimally. Sources for water specifically rainwater resources by making infiltration wells. Infiltration wells work to collect surface water and then absorb the soil to become ground water reserves. Converting sufficient (surplus) ground water, will compensate for drought in the dry season in the form of water flow.
PENEMPELAN TERITIP AMPHIBALANUS AMPHITRITE PADA SEMAI MANGROVE RHIZOPORA MUCRONATA DI AREA REHABILITASI MANGROVE DESA BASULE KABUPATEN KONAWE UTARA
Authors: Noer Fachrijal , Ramli Muhammad , Ira . 
Published: October 2021

AbstrakTeritip merupakan hama yang melekat pada batang maupun akar. Hal itu dapat merusak kulit batang mangrove dan mengakibatkan kematian mangrove. Penelitian ini bertujuan untuk mengetahui pengaruh parameter kualitas perairan terhadap kepadatan biofouling (teritip), kepadatan dan jenis biofouling (teritip) pada area rehabilitasi mangrove di Desa Basule Kabupaten Konawe Utara. Penentuan stasiun dilakukan secara purposive sampling yang berjumlah 3 stasiun. Pada masing-masing stasiun terdiri dari 3 sub stasiun sepanjang 100 meter dengan interval jarak 10 meter. Pemilihan stasiun ini didasarkan pada perbedaan karakteristik kerapatan mangrove. Penghitungan teritip dilakukan saat air menjelang surut dengan metode plot transek kuadrat. Pada setiap ulangan diletakkan petak ukuran 5x5 meter untuk kategori anakan dan plot 1 x 1 meter yang ditempatkan dalam petak ukuran 5x 5 meter secara acak. Hasil penelitian menunjukkan bahwa kepadatan tertinggi berada pada stasiun III yang mencapai 17,22 ind/m2 sementara kepadatan terendah terdapat pada stasiun I dengan nilai 12,66 ind/m2 . Hasil penelitian juga menunjukkan bahwa semakin tinggi kerapatan mangrove maka semakin tinggi kepadatan teritip.Kata Kunci: Amphibalanus amphitrite, penempelan, kepadatan, mangrove, Desa Basule
Synthesis of Sitagliptin Intermediate by a Multi-Enzymatic Cascade System Using Lipase and Transaminase With Benzylamine as an Amino Donor
Authors: Khobragade Taresh P. , Sarak Sharad , Pagar Amol D. , Jeon Hyunwoo , Giri Pritam , Yun Hyungdon 
Published: October 2021

Herein, we report the development of a multi-enzyme cascade using transaminase (TA), esterase, aldehyde reductase (AHR), and formate dehydrogenase (FDH), using benzylamine as an amino donor to synthesize the industrially important compound sitagliptin intermediate. A panel of 16 TAs was screened using ethyl 3-oxo-4-(2,4,5-trifluorophenyl) butanoate as a substrate (1). Amongst these enzymes, TA from Roseomonas deserti (TARO) was found to be the most suitable, showing the highest activity towards benzylamine (∼70%). The inhibitory effect of benzaldehyde was resolved by using AHR from Synechocystis sp. and FDH from Pseudomonas sp., which catalyzed the conversion of benzaldehyde to benzyl alcohol at the expense of NAD(P)H. Reaction parameters, such as pH, buffer system, and concentration of amino donor, were optimized. A single whole-cell system was developed for co-expressing TARO and esterase, and the promoter engineering strategy was adopted to control the expression level of each biocatalyst. The whole-cell reactions were performed with varying substrate concentrations (10–100 mM), resulting in excellent conversions (ranging from 72 to 91%) into the desired product. Finally, the applicability of this cascade was highlighted on Gram scale, indicating production of 70% of the sitagliptin intermediate with 61% isolated yield. The protocol reported herein may be considered an alternative to existing methods with respect to the use of cheaper amine donors as well as improved synthesis of (R) and (S) enantiomers with the use of non-chiral amino donors.
Protein- and Cell-Resistance of Zwitterionic Peptide-Based Self-Assembled Monolayers: Anti-Biofouling Tests and Surface Force Analysis
Authors: Chang Ryongsok , Quimada Mondarte Evan Angelo , Palai Debabrata , Sekine Taito , Kashiwazaki Aki , Murakami Daiki , Tanaka Masaru , Hayashi Tomohiro 
Published: October 2021

Peptide-based self-assembled monolayers (peptide-SAMs) with specific zwitterionic amino acid sequences express an anti-biofouling property. In this work, we performed protein adsorption and cell adhesion tests using peptide-SAMs with repeating units of various zwitterionic pairs of amino acids (EK, DK, ER, and DR). The SAMs with the repeating units of EK and DK (EK and DK SAMs) manifested excellent bioinertness, whereas the SAMs with the repeating units of ER and DR (ER and DR SAMs) adhered proteins and cells. We also performed surface force measurements using atomic force microscopy to elucidate the mechanism underlying the difference in the anti-biofouling property. Our measurements revealed that water-induced repulsion with a range of about 8 nm acts between EK SAMs (immobilized on both probe and substrate) and DK SAMs, whereas such repulsion was not observed for ER and DR SAMs. The strength of the repulsion exhibited a clear correlation with the protein- and cell-resistance of the SAMs, indicating that the interfacial water in the vicinity of EK and DK SAMs is considered as a physical barrier to deter protein and cells from their adsorption or adhesion. The range of the repulsion observed for EK and DK SAMs is longer than 8 nm, indicating that the hydrogen bonding state of the interfacial water with a thickness of 4 nm is modified by EK and DK SAMs, resulting in the expression of the anti-biofouling property.
Novel lncRNA-miRNA-mRNA Competing Endogenous RNA Triple Networks Associated Programmed Cell Death in Heart Failure
Authors: Zheng Yu , Zhang Yingjie , Zhang Xiu , Dang Yini , Cheng Yihui , Hua Wenjie , Teng Meiling , Wang Shenrui , Lu Xiao 
Published: October 2021

Objective: Increasing evidence has uncovered the roles of lncRNA-miRNA-mRNA regulatory networks in cardiovascular diseases. However, the crosstalk between ceRNA networks and development of heart failure (HF) remains unclear. This study was to investigate the role of lncRNA-mediated ceRNA networks in the pathophysiological process of HF and its potential regulatory functions on programmed cell death.Methods: We firstly screened the GSE77399, GSE52601 and GSE57338 datasets in the NCBI GEO database for screening differentially expressed lncRNAs, miRNAs and mRNAs. lncRNA-miRNA-mRNA regulatory networks based on the ceRNA theory were subsequently constructed. GO and KEGG enrichment analysis was conducted to predict potential biological functions of mRNAs in ceRNA networks. Differentially expressed mRNAs were then interacted with programmed cell death related genes. lncRNA-mediated ceRNA regulatory pathways on programmed cell death were validated with qRT-PCR testing.Results: Based on our bioinformatic analysis, two lncRNAs, eight miRNAs and 65 mRNAs were extracted to construct two lncRNAs-mediated ceRNA networks in HF. Biological processes and pathways were enriched in extracellular matrix. Seven lncRNA-mediated ceRNA regulatory pathways on programmed cell death, GAS5/miR-345-5p/ADAMTS4, GAS5/miR-18b-5p/AQP3, GAS5/miR-18b-5p/SHISA3, GAS5/miR-18b-5p/C1orf105, GAS5/miR-18b-5p/PLIN2, GAS5/miR-185-5p/LPCAT3, and GAS5/miR-29b-3p/STAT3, were finally validated.Conclusions: Two novel ceRNA regulatory networks in HF were discovered based on our bioinformatic analysis. Based on the interaction and validation analysis, seven lncRNA GAS5-mediated ceRNA regulatory pathways were hypothesized to impact programmed cell death including seven for apoptosis, three for ferroptosis, and one for pyroptosis. Upon which, we provided novel insights and potential research plots for bridging ceRNA regulatory networks and programmed cell death in HF.
Type 2 Diabetes Modifies Skeletal Muscle Gene Expression Response to Gastric Bypass Surgery
Authors: Barberio Matthew D. , Dohm G. Lynis , Pories Walter J. , Gadaleta Natalie A. , Houmard Joseph A. , Nadler Evan P. , Hubal Monica J. 
Published: October 2021

IntroductionRoux-en-Y gastric bypass (RYGB) is an effective treatment for type 2 diabetes mellitus (T2DM) that can result in remission of clinical symptoms, yet mechanisms for improved skeletal muscle health are poorly understood. We sought to define the impact of existing T2DM on RYGB-induced muscle transcriptome changes.MethodsVastus lateralis biopsy transcriptomes were generated pre- and 1-year post-RYGB in black adult females with (T2D; n = 5, age = 51 ± 6 years, BMI = 53.0 ± 5.8 kg/m2) and without (CON; n = 7, 43 ± 6 years, 51.0 ± 9.2 kg/m2) T2DM. Insulin, glucose, and HOMA-IR were measured in blood at the same time points. ANCOVA detected differentially expressed genes (p &lt; 0.01, fold change &lt; |1.2|), which were used to identify enriched biological pathways.ResultsPre-RYGB, 95 probes were downregulated with T2D including subunits of mitochondrial complex I. Post-RYGB, the T2D group had normalized gene expression when compared to their non-diabetic counterparts with only three probes remaining significantly different. In the T2D, we identified 52 probes upregulated from pre- to post-RYGB, including NDFUB7 and NDFUA1.ConclusionBlack females with T2DM show extensive downregulation of genes across aerobic metabolism pathways prior to RYGB, which resolves 1 year post-RYGB and is related to improvements in clinical markers. These data support efficacy of RYGB for improving skeletal muscle health, especially in patients with T2DM.
TNF Patterns and Tumor Microenvironment Characterization in Head and Neck Squamous Cell Carcinoma
Authors: Long Qian , Huang Chunyu , Meng Qi , Peng Jin , Yao Fan , Du Dingfu , Wang Xiaonan , Zhu Wancui , Shi Dingbo , Xu Xiangdong , Qi Xiang , Deng Wuguo , Chen Miao , Li Yizhuo , Yang Ankui 
Published: October 2021

BackgroundHNSCC is a heterogeneous disease, which arises from distinct anatomic subsites, associates with various risk factors and possesses diverse molecular pathological features. Generally, HNSCC is considered as an immunosuppressive disease, characterized by abnormal tumor immune microenvironment. The TNF family plays a crucial role in the survival, proliferation, differentiation, and effector functions in both immune and non-immune cells. However, the expression patterns of TNF in HNSCC remains to be systematically analyzed.MethodsWe downloaded transcriptional profile data of HNSCC from TCGA and GEO datasets. Unsupervised clustering methods were used to identify different TNF patterns and classify patients for further analysis. PCA was conducted to construct a TNF relevant score, which we called risk score.ResultsIn this study, we systematically evaluated the patterns of TNF family and tumor immune microenvironment characteristics of HNSCC patients by clustering the expression of 46 members of TNF family. We identified two subtypes with distinct clinical and immune characteristics in HNSCC and constructed a risk scoring system based on the expression profile of TNF family genes.ConclusionRisk score serves as a reliable predictor of overall survival, clinical characteristics, and immune cell infiltration, which has the potential to be applied as a valuable biomarker for HNSCC immunotherapy.
Cognitive Dysfunctions in Glaucoma: An Overview of Morpho-Functional Mechanisms and the Impact on Higher-Order Visual Function
Authors: Arrigo Alessandro , Aragona Emanuela , Saladino Andrea , Arrigo Davide , Fantaguzzi Federico , Battaglia Parodi Maurizio , Bandello Francesco 
Published: October 2021

Background: Glaucoma is a chronic, vision-threatening disease, and a major cause of legal blindness. The current view is no longer limited to the progressive optic nerve injury, since growing evidence strongly support the interpretation of glaucoma as a complex neurodegenerative disease. However, the precise pathogenic mechanisms leading to the onset and progression of central nervous system (CNS) impairment, and the functional consequences of this damage, are still partially understood. The main aim of this review is to provide a complete and updated overview of the current knowledge regarding the CNS involvement in glaucoma, and the possible therapeutic perspectives.Methods: We made a careful survey of the current literature reporting all the relevant findings related to the cognitive dysfunctions occurring in glaucoma, with specific remarks dedicated on the higher-order visual function impairment and the possible employment of neuroprotective agents.Results: The current literature strongly support the interpretation of glaucoma as a multifaceted chronic neurodegenerative disease, widely affecting the CNS. The cognitive impairment may vary in terms of higher-order functions involvement and in the severity of the degeneration. Although several neuroprotective agents are currently available, the development of new molecules represents a major topic of investigation for future clinical trials.Conclusions: Glaucoma earned the right to be fully considered a neurodegenerative disease. Glaucomatous patients may experience a heterogeneous set of visual and cognitive symptoms, progressively deteriorating the quality of life. Neuroprotection is nowadays a necessary therapeutic goal and a future promising way to preserve visual and cognitive functions, thus improving patients’ quality of life.
Effects of Transcranial Direct Current Stimulation and High-Definition Transcranial Direct Current Stimulation Enhanced Motor Learning on Robotic Transcranial Magnetic Stimulation Motor Maps in Children
Authors: Giuffre Adrianna , Zewdie Ephrem , Wrightson James G. , Cole Lauran , Carlson Helen L. , Kuo Hsing-Ching , Babwani Ali , Kirton Adam 
Published: October 2021

Introduction: Conventional transcranial direct current stimulation (tDCS) and high-definition tDCS (HD-tDCS) may improve motor learning in children. Mechanisms are not understood. Neuronavigated robotic transcranial magnetic stimulation (TMS) can produce individualised maps of primary motor cortex (M1) topography. We aimed to determine the effects of tDCS- and HD-tDCS-enhanced motor learning on motor maps.Methods: Typically developing children aged 12–18 years were randomised to right M1 anodal tDCS, HD-tDCS, or Sham during training of their left-hand on the Purdue Pegboard Task (PPT) over 5 days. Bilateral motor mapping was performed at baseline (pre), day 5 (post), and 6-weeks retention time (RT). Primary muscle was the first dorsal interosseous (FDI) with secondary muscles of abductor pollicis brevis (APB) and adductor digiti minimi (ADM). Primary mapping outcomes were volume (mm2/mV) and area (mm2). Secondary outcomes were centre of gravity (COG, mm) and hotspot magnitude (mV). Linear mixed-effects modelling was employed to investigate effects of time and stimulation type (tDCS, HD-tDCS, Sham) on motor map characteristics.Results: Twenty-four right-handed participants (median age 15.5 years, 52% female) completed the study with no serious adverse events or dropouts. Quality maps could not be obtained in two participants. No effect of time or group were observed on map area or volume. LFDI COG (mm) differed in the medial-lateral plane (x-axis) between tDCS and Sham (p = 0.038) from pre-to-post mapping sessions. Shifts in map COG were also observed for secondary left-hand muscles. Map metrics did not correlate with behavioural changes.Conclusion: Robotic TMS mapping can safely assess motor cortex neurophysiology in children undergoing motor learning and neuromodulation interventions. Large effects on map area and volume were not observed while changes in COG may occur. Larger controlled studies are required to understand the role of motor maps in interventional neuroplasticity in children.