bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Impact of Adaptive Behaviors on Balance: A Comparative Analysis of Static and Dynamic Balance in Athletes With and Without Intellectual Disabilities
Authors: Benito‐Martínez Elisa , Alonso‐Cortés Beatriz , Fernández‐Gorgojo Mario , Coto Martín Raul , Méndez Blanco Ricardo 
Published: February 2025

ABSTRACTBackgroundIndividuals with intellectual disability (ID) shows less development on their motor skills. Understanding the interaction between intellectual and physical performance will provide valuable information for the design of personalized interventions and support programs able to enhance active participation of these individuals.MethodA descriptive‐analytical study with 93 participants (59 with ID) was designed to evaluate both static and dynamic balance in athletes. In addition, the relationship between balance and adaptive behaviors was analyzed to determine whether static and dynamic balance is affected to a greater or lesser extent depending on the level of adaptive skills or intellectual capacity.ResultsSignificant differences were found in balance's variables between individuals with and without ID. IQ measurements (processing speed) and adaptive behaviors showed a correlation with some balance variables. In athletes with less ID levels, the correlation between balance and adaptive behaviors is more notable.ConclusionsThere are clear differences in both static and dynamic balance between individuals with and without intellectual disabilities. In addition, the level of adaptive skills and processing speed is related to balance, with those having lower levels of adaptive skills experiencing greater difficulties in maintaining better balance
Phenotypic and Genotypic Characteristics of Adult‐Onset Glutaric Aciduria Type 1: Report of Two Cases and a Literature Review
Authors: Wei Luhua , Li Jieyu , Xie Zhiying , Zhu Ying , Chen Jing , Zhao Yawen , Yuan Yun , Huang Yining , Yang Yanling , Wang Zhaoxia , Chen Jing 
Published: February 2025

ABSTRACTIntroductionGlutaric aciduria Type 1 (GA‐1) is an autosomal recessive inherited disorder caused by GCDH variations. GA‐1 is a rare disease that typically manifests in infancy and early childhood, with adult‐onset cases being even rarer. Currently, data on the clinical and genetic characteristics of adult‐onset GA‐1 remain limited.MethodsWe hereby reported two new cases of adult‐onset GA‐1 and systematically summarized reported studies to investigate its genotypic and phenotypic features.ResultsPatient 1 presented with seizures as the onset symptom. Patient 2 exhibited recurrent stroke‐like episodes. Brain magnetic resonance imaging showed subependymal lesions. Urine organic acid analyses were performed since both patients had hyperhomocysteinemia (HHcy) and found significantly elevated glutaric acid and 3‐hydroxyglutaric acid. Genetic analysis further identified biallelic missense variants in GCDH in both patients (Patient 1: c.383G> A, c.937C> T; Patient 2: c.533G> A, c.1205G> A). A literature review found seven cases and 12 variants in adult‐onset GA‐1. Most of them showed nonspecific neurological manifestations. The most common symptoms were cognitive impairment and headache. Subependymal lesions have been reported in five of seven cases. One of them also had HHcy. All adult‐onset GA‐1 cases were high excretors. All GCDH variants are located in nonactive binding regions.ConclusionThis study characterized the phenotype of adult‐onset GA‐1 emphasizing subependymal lesions and the coexistence of HHcy. The latter might suggest the influence of environmental factors on the age of onset. No clear genotype–phenotype correlation was found.
Strategic Linkages to ESG Performance: The Role of Performance Measurement System and Psychological Empowerment
Authors: Dong Xiaonan , Son Sungjin , Roh Taewoo 
Published: February 2025

ABSTRACTSustainable development strategies (SDS) have been widely studied from both an innovation and financial perspective, as they play a critical role in balancing the environmental, social, and governance (ESG) pillars. However, the causal pathways connecting SDS to internal capabilities, such as performance measurement systems (PMS) and human resource management (HRM) practices, and their subsequent impact on both ESG performance (ESGP) and financial performance (FP) remain underexplored. This study integrates the sustainable balanced scorecard (SBSC) framework and resource orchestration theory (ROT) to examine how PMS control types (i.e., diagnostic and interactive), PMS justice (PMSJ), and psychological empowerment (PE) mediate the relationships between SDS, ESGP, and FP. Using data from China's top 500 manufacturing firms, we find that SDS positively impacts FP by enhancing ESGP. Furthermore, PMS control types, PMSJ, and PE act as sequential mediators, clarifying the internal mechanisms linking SDS to sustainable performance. These findings suggest that strategic attention to both PMS types and employee empowerment is crucial for achieving ESG as well as financial goals.
Flocculation‐based clarification for production of protein therapeutics in Pichia pastoris: Recombinant human serum albumin as a case study
Authors: Hebbi Vishwanath , Kumar Jashwant , Rathore Anurag S. 
Published: February 2025

AbstractPichia pastoris has been used as an expression system for multiple biotherapeutic products due to the unique advantages it offers with respect to cell density, protein titer, extracellular expression, and other such advantages. However, clarification of cell broth presents a significant challenge, primarily due to the high cell density (up to 50% W/V). Additionally, the abundance of host cell proteins complicates secondary clarification, impacting subsequent chromatographic, and filtration steps. In this study, a flocculation‐based cell clarification method has been developed for the primary recovery of protein therapeutic products from Pichia broth. Human serum albumin (HSA) has been used as a case study. Unlike polymer‐based flocculants, which introduce challenges in process clearance, the proposed method employs process‐compatible salts. The approach has been designed and optimized using Quality by Design (QbD) principles, achieving a clarification efficiency with up to 90% recovery and a reduction of host cell proteins by up to 30%. The proposed methodology would be applicable to other biotherapeutic applications involving protein production in P. pastoris.
Unveiling the Protective Potential of Crocin in Septic Acute Liver Injury via Assessment of TLR4/HGM1/NF‐κB Signaling Pathway, Oxidative Stress and Heat Shock Response
Authors: Akin Ali Tugrul , Kaymak Emin , Ceylan Tayfun , Kuloglu Nurhan , Karabulut Derya , Toluk Ayse 
Published: February 2025

ABSTRACTSepsis, defined as a systemic inflammatory response, is one of the conditions with the highest mortality rates. Crosin (CRO) is one of the active ingredients in saffron and known for its various pharmacological effects. It has been reported to have protective and healing effects on liver tissue. In this study, we aimed to investigate the protective role of CRO in lipopolysaccharide (LPS)‐induced acute liver injury. 40 male Wistar Albino rats aged 8–12 weeks were randomly divided into 4 groups: Control, CRO (50 mg/kg, intraperitoneal administration for 9 days), LPS (30 mg/kg, single dose), and LPS + CRO (50 mg/kg CRO for 9 days along with a single dose of 30 mg/kg LPS). Following the experimental procedure, liver and blood samples were collected for further analyses. Histopathological analysis revealed a marked increase in liver damage in the LPS group, as evidenced by significant histopathological changes. In contrast, the liver histology in the LPS + CRO group closely resembled that of the Control and CRO groups, exhibiting substantially less damage compared to the LPS group. Immunohistochemical examinations showed a significant increase in the expressions of TLR4, HMGB1, NF‐κB, TNF‐ α, HSP70, and HSP90 in the LPS group. However, in the LPS + CRO group, the levels of these markers were significantly lower compared to the LPS group. ELISA analyses showed a significant increase in MDA, IL‐6, and TGF‐β and a decrease in SOD, CAT, GSH levels in the LPS group. Conversely, in the LPS + CRO group, CRO applications exhibited a significant protective effect on these alterations. Additionally, AST, ALT, and LDH levels were significantly elevated in the LPS group, while albumin levels were lower in the LPS group. CRO applications in the LPS + CRO group were observed to have a protective effect on these parameters. We believe that CRO holds significant potential in the treatment of acute inflammatory diseases such as septic acute liver injury and should not be overlooked.
The Influence of Cyanidin‐3‐Glucoside on the Modulation of Immune Cell Responses by Mesenchymal Stem Cell‐Conditioned Medium
Authors: de Freitas Sumara , Makiyama Edson Naoto , Neves Bruna Roberta Oliveira , Pizzolato Cezar Iolanda Silva Rafael , Gonçalves Carlos Eduardo da Silva , Rogero Marcelo Macedo , Fock Ricardo Ambrósio 
Published: February 2025

ABSTRACTMesenchymal stem cells (MSCs) are emerging as promising therapeutic agents due to their immunomodulatory effects, primarily mediated via paracrine signaling. Similarly, anthocyanins, such as cyanidin‐3‐glucoside (C3G), have demonstrated significant anti‐inflammatory properties. In this context, this study investigated the immunomodulatory potential of C3G on MSCs, and subsequent effects on macrophage and lymphocyte responses. Cytotoxicity assays identified 50 µM as the highest nontoxic C3G concentration for MSCs. Flow cytometry confirmed that C3G treatment did not affect MSC viability or cell cycle distribution, even under LPS stimulation. Cytokine production by MSCs was evaluated after treatment with C3G and LPS. While no significant changes were observed in IL‐6, IL‐10, TGF‐β, or PGE2 levels, IL‐1β production was significantly reduced in LPS‐stimulated MSCs treated with C3G. Protein expression analysis revealed decreased NFκB phosphorylation in LPS‐stimulated MSCs treated with C3G, with no changes detected in STAT‐3 or PCNA expression. The immunomodulatory effects of MSC‐derived conditioned media on macrophages and lymphocytes were also assessed. In LPS‐stimulated macrophages, conditioned media from MSCs reduced the production of IL‐1β, IL‐6, and IL‐12. Interestingly, conditioned media from C3G‐treated MSCs specifically decreased TNF‐α levels, enhanced IL‐10 secretion, and further inhibited NFκB phosphorylation. In LPS‐stimulated lymphocytes, conditioned media from C3G‐treated MSCs suppressed IL‐2 production while increasing IL‐10 levels. In summary, these findings demonstrate that conditioned media from C3G‐treated MSCs modulates immune cell responses more effectively than C3G alone. C3G influences the paracrine activity of MSCs, resulting in a shift in the secretory profile and subsequent effects on immune cell behavior.
Are Therapists Less Skilful in Teletherapy Than In‐Person Therapy Scenarios? A Latent Profile Analysis of Facilitative Interpersonal Skills
Authors: Lin Tao , Doorn Katie Aafjes‐van , Heckman Timothy G. , Antebi‐Lerman Eva , Anderson Timothy 
Published: February 2025

ABSTRACTEmerging research suggests that therapists feel less efficacious administering therapy remotely than in‐person. These findings, however, are based almost exclusively on therapist self‐reports. The current study compared therapists' self‐reported and observer‐rated therapeutic skills across simulated in‐person and teletherapy scenarios to determine if common factors and therapeutic skills differed between the two treatment settings. A diverse sample of 223 licensed therapists and trainees simulated the provision of psychotherapy using standardised clips of challenging therapeutic scenarios in both tele‐ and in‐person therapy. Common factors and therapeutic skills in tele‐ and in‐person therapy simulations were rated by trained coders and compared. Latent profile analysis identified latent subgroups of therapists based on differences between skills when providing in‐person and teletherapy. Both self‐report and observer‐rated measures indicated that therapists demonstrated reduced common factors and therapeutic skills in teletherapy scenarios than in‐person therapy scenarios. Three latent profiles based on differences in skills between teletherapy versus in‐person therapy among therapists were identified: developing teletherapists (54.26%), teletherapy experts (34.98%) and teletherapy‐challenged therapists (10.76%). No variable assessed in the study differentiated the three groups. Therapists generally demonstrated lower levels of therapeutic skills in teletherapy compared with in‐person therapy settings. Considerable variability in the skill difference between the two psychotherapy formats was found among therapists. Trainings targeting skills that are complicated by teletherapy (e.g., emotional expression) are needed.
Integrated Sensing and Communication in Next‐Generation Wireless Networks: Insights and Trends
Authors: Singh Shatakshi , Samal Umashankar 
Published: February 2025

ABSTRACTIntegrated sensing and communication (ISAC), wherein sensing and communication share the same frequency band and hardware, has emerged as a pivotal technology in future wireless systems. A thorough study is required for researchers because ISAC has attracted a lot of interest and attention from academia and industry. In this paper, we present a bibliometric review that seeks to map the current state of ISAC research by addressing three crucial aspects. The aspects are (1) locating key journals, and significant authors, and creating network maps within ISAC; (2) defining theme‐based clusters based on keyword co‐occurrence analysis; and (3) developing a strong research framework to direct future ISAC investigations. This study provides profound insights and a structured foundation for researchers, enhancing the understanding and development of ISAC technologies. By highlighting significant advancements and research trends, this review aims to foster further innovation and academic discourse in the field of ISAC.
Refining the trophic diversity, network structure, and bottom‐up importance of prey groups for temperate reef fishes
Authors: Zarco‐Perello S. , Bennett S. , Goetze J. , Holmes T. H. , Stuart‐Smith R. D. , White E. R. 
Published: February 2025

AbstractMarine fish communities are highly diverse and contribute significantly to ecosystem processes. However, understanding their specific functional roles and the importance of different prey groups for sustaining fish communities has been limited by the historical classification of fishes into a few coarse trophic guilds. Using diet information to perform a high‐resolution trophic classification of 298 temperate reef fish species distributed across south‐western Australia, we built metacommunity and subregional trophic networks to evaluate the most important trophic relationships and energy pathways in temperate reefs. We identified 26 specialized trophic guilds within the groups of herbivores, zoobenthivores, zooplanktivores, piscivores, and cleaners. Zoobenthivorous fishes had the highest species richness and trophic diversity with 191 species in nine guilds. Consumers of crustaceans showed greater species redundancy at the metacommunity level. In contrast, a low redundancy of echinodermivores could represent a risk to local capacity for top‐down control of sea urchins across the region. Finer scale analysis of prey at the family level showed that piscivorous guilds may influence different trophic pathways, with some guilds consuming other piscivorous fishes, while others consume lower trophic levels, particularly crustaceavores. Evidence of predation on herbivorous guilds was only found for turf grazers, suggesting that fish herbivory might not function as a major direct link between primary producers and higher trophic levels. Among the prey consumed by fishes, micro‐crustaceans and decapods accounted for 33% of all diet proportions. The importance of macrophytes to the fish community likely resides indirectly through the trophic pathway of herbivorous and detritivorous invertebrates, particularly crustaceans, which are more consumed by fishes than macrophytes themselves. Comparison of trophic networks in the region showed that warmer locations had higher species redundancy per node and higher strength in trophic interactions. Yet, all networks had structural properties consistent with the meta‐network regarding the importance of prey groups and modularity. Considering high‐resolution predator–prey interactions enhances our understanding of the blue‐print of ecosystem functions in shallow marine systems. Identifying the specific trophic significance of different consumers and prey groups is important for ecological forecasting and the prioritization of conservation and resource management regulations in our current fast‐changing world.
Baseline characteristics of contemporary trial participants with heart failure and reduced ejection fraction: The VICTOR trial
Authors: Saldarriaga Clara I. , Zannad Faiez , McMullan Ciaran J. , Xing Aiwen , Gates Davis , Anstrom Kevin J. , Bonaca Marc P. , Corda Stefano , Ezekowitz Justin A. , Lam Carolyn S.P. , Lewis Eldrin F. , Lindenfeld JoAnn , Mentz Robert J. , O'Connor Christopher , Patel Mahesh , Ponikowski Piotr , Reddy Yogesh N.V. , Rosano Giuseppe M.C. , Senni Michele , Udelson James , Voors Adriaan A. , Butler Javed 
Published: February 2025

AimsTo describe the baseline characteristics of the participants in the VICTOR (Vericiguat Global Study in Patients with Chronic Heart Failure; NCT05093933) trial and compare them to recent trials in patients with heart failure and reduced ejection fraction (HFrEF).Methods and resultsBaseline characteristics were evaluated in 6105 patients randomized to vericiguat or placebo. The mean age of the participants was 67 ± 11 years, 23.6% were women, 64.4% were White, and 10.7% were self‐identified Black. Overall, 29.1% of participants were enrolled in Latin and South America, 27.8% and 18.5% in Eastern and Western Europe, 14.0% in Asia‐Pacific and 10.6% in North America. The mean left ventricular ejection fraction was 30 ± 7% and 79% had New York Heart Association class II symptoms. Mean estimated glomerular filtration rate was 70.9 ± 24.0 ml/min/1.73 m2. Median N‐terminal pro‐B‐type natriuretic peptide level was 1476 (970–2495) pg/ml and 47.5% of participants had no prior hospitalization for heart failure. Baseline therapy included 94.4% beta‐blockers, 94.3% renin–angiotensin system modulation (including 56.0% on an angiotensin receptor–neprilysin inhibitor), 77.7% mineralocorticoid receptor antagonists, 59.1% sodium–glucose cotransporter 2 inhibitors, and 32.9% implantable cardioverter‐defibrillators. Overall characteristics were relatively similar to other recent HFrEF trials but the VICTOR trial enrolled a higher proportion of participants receiving contemporary drug and device therapy.ConclusionThe VICTOR trial enrolled the most optimally treated population in a phase III heart failure trial. These features will facilitate assessment of the benefit of vericiguat and elucidate the outcomes of patients on up‐to‐date medical therapy.
Amination of Flavonoids Possessing a Pyrogallol Group in Cell Culture Medium at 37°C
Authors: Zhang Haolin , Zhang Jingjing , Cao Hui , Högger Petra , Arroo Randolph , Farag Mohamed A. , Shpigelman Avi , Xiao Jianbo , Li Chunlin 
Published: February 2025

ABSTRACTA class of flavonoid aminated derivatives that had been consistently overlooked in literature was shown to be formed as artefacts in cell culture medium. In this study, 34 flavonoids from different subclasses were incubated in Dulbecco's modified Eagle's Medium (DMEM) at 37°C for 2 h to identify the reaction mechanism behind aminated derivatives formation from flavonoids. Baicalein, scutellarein, dihydromyricetin, (−)‐gallocatechin (GC), (−)‐epigallocatechin (EGC), (−)‐GC gallate, and (−)‐EGC gallate were found to yield corresponding nitrogenous derivatives in both DMEM and amino acid solution. The nitrogen source of these seven flavonoid ‐aminated derivatives was revealed to be amino acids in DMEM. The pyrogallol group of the flavonoids was a key structural motif, being first oxidized into quinone and then further reacting with amino acids (Strecker degradation) to yield aminated flavonoids and corresponding aldehydes. A slightly alkaline environment accelerated the amination of flavonoids, possibly via the formation of flavonoid quinone. These results provide the mechanistic evidence for the in vitro generation of flavonoid ‐aminated derivatives, yet to be tested using in vivo assays.
Impact of High Hydrostatic Pressure on the Physicochemical Characteristics, Functional Properties, Structure, and Bioactivities of Tenebrio molitor Protein
Authors: Zhang Can , Suo Huayi , Song Jiajia 
Published: February 2025

ABSTRACTThis study aimed to explore the influence of high hydrostatic pressure (HHP) treatment on the structure, functional characteristics, and bioactivities of Tenebrio molitor protein. The results showed that HHP induced dissociation of T. molitor protein, exposing hydrophobic groups and reducing particle size, which in turn reduced turbidity. Additionally, 600 MPa treatment significantly reduced the foaming stability and emulsifying activity of T. molitor protein. Treatments at 200 MPa and 400 MPa significantly reduced emulsion stability, whereas 400 MPa treatment significantly increased oil retention. HHP treatment also altered the secondary and tertiary structures of T. molitor protein, as demonstrated by circular dichroism and fluorescence spectra. Furthermore, HHP treatment significantly affected the antibacterial and antioxidant activities of T. molitor protein. This study provides a theoretical framework for using HHP to modify T. molitor protein.
Outcomes of patients with relapsed or refractory primary mediastinal B‐cell lymphoma treated with anti‐CD19 CAR‐T cells: CARTHYM, a study from the French national DESCAR‐T registry
Authors: Galtier Jean , Mesguich Charles , Sesques Pierre , Dupont Vivien , Bachy Emmanuel , Di Blasi Roberta , Thieblemont Catherine , Gastinne Thomas , Cartron Guillaume , Brisou Gabriel , Gros François‐Xavier , Decroocq Justine , Morschhauser Franck , Rubio Marie‐Thérèse , Drieu La Rochelle Laurianne , Le Bras Fabien , Carras Sylvain , Chauchet Adrien , Bay Jacques‐Olivier , Joris Magalie , Loschi Mickael , Tanguy‐Schmidt Aline , Marquet Alexandra , Camus Vincent , Le Gouill Steven , Houot Roch , Bouabdallah Krimo 
Published: February 2025

ABSTRACTPrimary mediastinal B‐cell lymphoma (PMBL) is often cured with dose‐dense anthracycline‐based regimens but the prognosis at relapse or progression remains poor. While anti‐CD19 CAR‐T cell therapy has dramatically improved outcomes in relapsed or refractory large B‐cell lymphoma, far less is known about their efficacy in PMBL. Using the systematic record of all patients treated with CAR‐T cells prospectively included in the DESCAR‐T registry in France, along with centrally reviewed positon‐emission tomography (PET) imaging, we describe the outcomes and key determinants of treatment success in PMBL patients treated over a 6‐year period. Among 82 patients infused in the registry we observed a best complete response (CR) rate, 2‐year progression‐free survival (PFS), and 2‐year overall survival (OS) of 68.1%, 57.4%, and 73.8%, respectively. Outcomes were even better for the 62 patients infused with axicabtagene ciloleucel, with best CR rate, 2‐year PFS, and 2‐year OS reaching 74.5%, 70.4%, and 86.9%, respectively. Achieving a Deauville score of 1–4 or a ΔSUVmax reduction of more than 24% at the 1‐month evaluation was associated with excellent outcomes, whereas increased total metabolic tumor volume baseline PET increased the risk of treatment failure. Surprisingly, neither the response to bridging therapy nor the type of bridging therapy (chemotherapy versus immune checkpoint inhibitors) were associated with long‐term outcomes. In conclusion, this study confirms that anti‐CD19 CAR‐T cells as a valid standard‐of‐care for relapsed and refractory PMBL and highlights key determinants of treatment success.