bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supercompensation in Elite Water Polo: Heart Rate Variability and Perceived Recovery
Authors: Botonis Petros G. , Smilios Ilias , Toubekis Argyris G. 
Published: July 2021

AbstractWe examined the association of heart rate variability assessed with the logarithm of the root mean square of successive differences (LnRMSSD) and perceived recovery status of nine elite water polo players with the fluctuations of the internal training load (ITL). ITL, post-wakening LnRMSSD, and measures of perceived recovery were obtained across one regeneration week, during two mesocycles of intensified preseason training (PR1, PR2) and during two mesocycles of in-season training (IN1, IN2). ITL at PR1 and PR2 was increased by 60–70% compared to regeneration week (p<0.01) and was reduced by 30% at IN1 and IN2 compared to PR1 and PR2 (p<0.01). Weekly averaged LnRMSSD (LnRMSSDmean) was higher in IN2 compared to regeneration week and PR2 (p<0.01 and p<0.05, respectively). Perceived recovery was higher at IN1 and IN2 compared to PR2 (p=0.01 and p<0.001, respectively). ITL correlated with LnRMSSD in the preseason (r=–0.26, p=0.03). Nonetheless, similar association was not apparent during the in-season period (r=0.02, p=0.88). Cardiac autonomic perturbations may not occur when an increment of internal training load is less than 60–70%. However, the reduction of training load in season by 30% improves both LnRMSSDmean and perceived recovery status, implying that training periodization may lead players in supercompensation.
Thoraxsonografie bei Aufnahme auf einer COVID-Verdachtsstation – differenzialdiagnostisch hilfreich oder Zeitverschwendung?
Authors: Salzmann Christian , Schmidt Christa , Sauvigny Daniela , Janneck Matthias , Lock Guntram 
Published: July 2021

Zusammenfassung
Einleitung Bei Patienten mit COVID-19 werden typische, teils schwere Lungenveränderungen beschrieben. Neben dem Einsatz des Thorax-CT wurde bereits frühzeitig auf einen diagnostischen Nutzen durch den Einsatz des Lungenultraschalls hingewiesen.Diese Pilotstudie untersucht die Frage, ob die Thoraxsonografie bei auf COVID-19 hinweisenden Symptomen in der Frühphase differenzialdiagnostisch sinnvoll eingesetzt werden kann.
Methoden 46 Patienten aus der „ersten Welle“ der COVID-19-Pandemie (23 mit gesicherter, 23 mit im weiteren Verlauf nicht bestätigter Infektion als Kontrollen), die initial mit dem klinischen Verdacht auf eine SARS-CoV-2-Infektion auf die COVID-Verdachtsstation eines akademischen Lehrkrankenhauses aufgenommen worden waren, wurden kurz nach ihrer Aufnahme mittels Lungenultraschall untersucht. Die endgültige Diagnose einer Infektion wurde mittels – teils wiederholtem – PCR-Nasen-/Rachenabstrich gestellt oder ausgeschlossen. Die erhobenen Befunde der SARS-CoV-2-Patienten und der Kontrollen wurden gegenübergestellt und hinsichtlich signifikanter Unterschiede der thoraxsonografischen Parameter analysiert.
Ergebnisse Es zeigten sich deutliche Unterschiede in den Lungenultraschallbefunden beider Gruppen. In der COVID-Gruppe fanden sich signifikant weniger A-Linien, mehr pathologische B-Linien (vermehrt oder konfluierend) sowie mehr Konsolidierungen. Pleuraergüsse traten in der Kontrollgruppe signifikant häufiger auf. Der berechnete Lungen-Ultraschall-(LUS)-Score war in der COVID-Gruppe höher als in der Kontrollgruppe. Eine sichere Unterscheidung zwischen beiden Gruppen war jedoch nicht möglich, da die Verteilungsbreite der Veränderungen bzw. des LUS-Score zu groß war.
Diskussion In einem klinischen Setting zeigt die Thoraxsonografie bei SARS-CoV-2-Infizierten häufigere und andere Läsionen als bei Patienten, bei denen sich der initiale klinische Verdacht nicht bestätigte. Aufgrund des großen Überlappungsbereiches war die Thoraxsonografie jedoch nicht geeignet, um bei initialem klinischen Verdacht zwischen SARS-CoV-2-Infizierten und Nicht-Infizierten hinreichend sicher zu unterscheiden.
Delta Neutrophil Index as a Promising Biomarker for Placental
Implantation Disorders
Authors: Karakoç Gökhan , Yalcin Serenat Eris , Yavuz And , Sarsmaz Kemal , Şengül Mustafa , Yucel Aykan 
Published: July 2021

Abstract
Objective We aimed to investigate the value of maternal serum delta
neutrophil index (DNI) levels in predicting placenta accreta spectrum in
patients with placenta previa.
Methods The patients who were found to have placenta previa totalis were
included in our study. Location of placental implantation and depth of
myometrial invasion were defined by transabdominal and transvaginal 2D gray
scale and Doppler sonography and confirmed during cesarean section and
histopathological evaluation. Patients were subjected to complete blood counts,
including prenatal hemoglobin level, total white blood cell count, differential
leukocyte count, and platelet count. The following formula was used to calculate
the DNI level: DNI (%)=(leukocyte subfraction analyzed by
cytochemical reaction in the MPO channel) - (leukocyte subfraction analyzed
using the nuclear lobularity channel with reflected light beam
measurements).
Results Placenta previa was detected in 295 patients; 31 of them had PAS.
As the control group, 189 patients were evaluated. In the group with PAS, the
DNI value was significantly higher (p<0.05) than the other groups. DNI
value in the group with previa only was also significantly higher
(p<0.05) than the control group. In the univariate model, a significant
(p<0.05) effect of DNI value and number of cesarean sections was
observed in separating patients with previa only and PAS. In the multivariate
model, a significant independent (p>0.05) effect of the DNI value was
observed in separating patients with previa only and PAS. Significant efficiency
of DNI value [area under the curve 0.899 (0.814–0.984)] was observed in
differentiating patients with previa only and PAS. Significant efficacy of DNI 5
cut-off value [area under the curve 0.858 (0.770–0.946)] was observed in
distinguishing patients with previa only and PAS (sensitivity 80.0%,
positive predictive value 64.9%, specificity 91.6%, negative
predictive value 95.9%)
Conclusion Maternal DNI values seem to be beneficial with respect to both
previa and invasion prediction. Although more comprehensive studies are needed
to test this proposition, prediction studies of this practical test should be
done in different trimesters and its usability with respect to preventing
maternal-fetal morbidity should be investigated.
No association of Brain-derived neurotrophic factor with striatal dopamine transporter availability in healthy subjects
Authors: Nam Hyun-Yeol , Seo Seongho , Lee Myung Jun , Kim Keunyoung , Kim In Joo , Pak Kyoungjune 
Published: July 2021

Abstract
Objective Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays a key role in brain plasticity, synaptic function, neuronal survival, learning, and memory formation. We aimed to investigate the association of BDNF with dopamine transporter (DAT) availabilities measured by positron emission tomography (PET) in healthy subjects.
Methods Thirty-five healthy, male subjects without brain injury, neuropsychological disorders were included in this study. The emission data were acquired over 90 mins with 50 frames after injection of 18F-FP-CIT using PET. Binding potentials (BPNDs) of ventral striatum (VST), caudate nucleus, putamen were measured with the simplified reference tissue method. The serum BDNF level (pg/mL) was measured through enzyme-linked immunosorbent assay method.
Results Thirty-five healthy males with a mean age of 24.4 ± 2.7 years were included in this study. Multiple regression was done to investigate the association between striatal BPNDs from VST, caudate nucleus, putamen and serum BDNF after adjusting for age. None of striatal BPNDs from VST (p=0.8450), caudate nucleus (p=0.4783), and putamen (p=0.7994) were associated with serum BDNF.
Conclusion Striatal DAT availabilities measured from PET were not associated with the serum BDNF in healthy subjects.
Population Pharmacokinetics Modeling of Lamotrigine in Jordanian
Epileptic Patients Using Dried Blood Spot Sampling
Authors: Dodin Yasmeen I. , Suyagh Maysa F. , Saleh Mohammad I. , Nuseir Ziad T. , Aburuz Salah M. , Al-Qudah Abdelkarim A. , Masri Amira T. , Younes Abdallah M. , Al-Ghazawi Mutasim A. 
Published: July 2021

Abstract
Aims To characterize the population pharmacokinetics of lamotrigine in
Jordanian epileptic patients and to identify factors affecting therapeutic
parameters.
Patients and Methods A population pharmacokinetics model for lamotrigine
was established based on a prospectively collected data of 52 steady-state
concentrations from 38 adult and pediatric patients with epilepsy. Lamotrigine
concentrations were determined by a dried blood spot liquid chromatography
method. Data were analyzed according to a one-compartment model with first-order
absorption and elimination using the nonlinear mixed effect modeling program.
The covariates effect of total body weight, gender, age, and co-medication with
topiramate, carbamazepine, phenytoin, phenobarbital, and valproic acid on
lamotrigine clearance were investigated using a stepwise forward addition
followed by a stepwise backward elimination.
Results The final population pharmacokinetics model for lamotrigine
clearance was as follows:
CL/Fpop=θ1*exp
(θ3*age)*exp
(θ5*carbamazepine)*exp
(θ6*valproic acid) , where θ1
is the relative clearance (L/hr) estimated, and θ3,
θ5, and θ6 are the fixed parameters
relating to age and co-medication with carbamazepine and valproic acid,
respectively.The population mean value of lamotrigine total clearance generated
in the final model (with covariates) was 2.12 L/hr.
Inter-individual variability and residual unexplained variability expressed as
the coefficient of variation was 37.1 and 26.1%, respectively.
Conclusion Lamotrigine total clearance in the Jordanian patients is
comparable to that reported by others for Caucasian patients. Age and
concomitant therapy with carbamazepine and valproic acid significantly affected
lamotrigine clearance, and accounted for 48% of its inter-individual
variability.
Electrochemically Catalyzed N–N Coupling and Ring Cleavage Reaction of 1H-Pyrazoles
Authors: Nikpour Farzad , Zandi Sara , Sharafi-Kolkeshvandi Mahnaz 
Published: July 2021

AbstractThe electrocatalyzed N–N coupling and ring cleavage reaction of 3-methyl-, 3,5-dimethyl-, 3-methyl-5-phenyl- and 3,5-diphenyl-1H-pyrazole was investigated and led to the electro-organic synthesis of new heterocyclic compounds. The results revealed that electrochemically produced 1H-pyrazoleox plays the role of acceptor in a reaction with the starting molecule via a N–N coupling and ring cleavage reaction of pyrazoles. The proposed reaction sequence consists of anodic oxidation, dimerization, rearrangement and reduction. The electrochemically catalyzed reactions were accomplished under constant-current and constant-potential conditions using an undivided electrochemical cell with the advantages of mild reaction conditions, remarkable yields and environmental compatibility.
The Growing Impact of Cardiovascular Oncology: Epidemiology and Pathophysiology
Authors: Tufano Antonella , Coppola Antonio , Galderisi Maurizio 
Published: July 2021

AbstractProgress in the treatment of cancer has significantly improved survival of oncologic patients in recent decades. However, anticancer therapies, particularly some new, more potent and targeted agents, are potentially cardiotoxic. As a consequence, cardiovascular complications, including heart failure, arterial hypertension, coronary artery disease, venous thromboembolism, peripheral vascular disease, arrhythmias, pericardial disease, and pulmonary hypertension, as related to cancer itself or to anticancer treatments, are increasingly observed and may adversely affect prognosis in oncologic patients. Cardiovascular oncology is an emerging field in cardiology and internal medicine, which is rapidly growing, dealing with the prevention, the early detection, and the management of cardiovascular disease, in all stages of anticancer therapy and during the survivorship period, now crucial for reducing cardiovascular morbidity and mortality in cancer patients. In this narrative review, the existing literature regarding the epidemiology of cardiovascular oncology, the mechanisms of cardiovascular complications in cancer, and the pathophysiology of cardiotoxicity related to chemotherapeutic agents, targeted therapies, immunotherapies, and radiotherapy will be analyzed and summarized.
Spasmodic Abdominal Pain and Other Gastrointestinal Symptoms in Pontocerebellar Hypoplasia Type 2
Authors: Janzarik Wibke G. , Krägeloh-Mann Ingeborg , Langer Thorsten , van Buiren Miriam , Schaefer Hans E. , Gerner Patrick 
Published: July 2021

Abstract
Introduction Pontocerebellar hypoplasia type 2 (PCH2) is a rare neurodevelopmental disease with a high disease burden. Besides neurological symptoms, somatic symptoms, such as gastroesophageal reflux (GERD) and failure to thrive, are major contributors to this burden.
Methods We report three patients with genetically confirmed PCH2A and significant gastrointestinal (GI) symptoms.
Results Apart from impaired swallowing and GERD, which are frequently reported in patients with PCH2, all three patients suffered from episodes of spasmodic abdominal pain and restlessness. In one severely affected patient, lack of intestinal alkaline phosphatase (IAP) is demonstrated.
Conclusion GI symptoms are common in PCH2. We draw attention to episodes of spasmodic abdominal pain seriously, aggravating the condition of the patients, especially their movement disorder, and discuss the role of IAP.
IL1RAPL1 Gene Deletion in a Female Patient with Developmental Delay and Continuous Spike-Wave during Sleep
Authors: Jiang Evan , Fitzgerald Mark P. , Helbig Katherine L. , Goldberg Ethan M. 
Published: July 2021

AbstractInterleukin-1 receptor accessory protein-like 1 (IL1RAPL1) encodes a protein that is highly expressed in neurons and has been shown to regulate neurite outgrowth as well as synapse formation and synaptic transmission. Clinically, mutations in or deletions of IL1RAPL1 have been associated with a spectrum of neurological dysfunction including autism spectrum disorder and nonsyndromic X-linked developmental delay/intellectual disability of varying severity. Nearly all reported cases are in males; in the few reported cases involving females, the clinical presentation was mild or the deletion was identified in phenotypically normal carriers in accordance with X-linked inheritance. Using genome-wide microarray analysis, we identified a novel de novo 373 kb interstitial deletion of the X chromosome (Xp21.1-p21.2) that includes exons 4 to 6 of the IL1RAPL1 gene in an 8-year-old girl with severe intellectual disability and behavioral disorder with a history of developmental regression. Overnight continuous video electroencephalography revealed electrical status epilepticus in sleep (ESES). This case expands the clinical genetic spectrum of IL1RAPL1-related neurodevelopmental disorders and highlights a new genetic association of ESES.
Evaluation of HiCrome KPC Agar for the Screening of Carbapenem-Resistant Enterobacterales Colonization in the ICU Setting of a Tertiary Care Hospital
Authors: Mahapatra Ashoka , Nikitha K , Rath Sutapa , Behera Bijayini , Gupta Kavita 
Published: July 2021

Abstract
Background Spread of carbapenem-resistant Enterobacterales (CRE) is a significant concern in intensive care unit (ICU) settings. Approaches to routine screening for CRE colonization in all ICU patients vary depending on institutional epidemiology and resources. The present study was aimed to evaluate the performance of HiCrome Klebsiella pneumoniae carbapenemase (KPC) agar for the detection of CRE colonization in ICU settings taking the Centers for Disease Control and Prevention (CDC) recommended method as reference.
Methods Two-hundred and eighty rectal swabs (duplicate) from 140 patients were subjected to CRE detection in HiCrome KPC agar and MacConkey agar (CDC criteria).
Results Using CDC method, total 41 CRE isolates were recovered comprising of 29 Escherichia coli, 11 Klebsiella, and 1 Enterobacter spp. On the other hand, 49 isolates of CRE recovered from 140 rectal swabs using HiCrome KPC agar, out of which 33 were E. coli, 15 Klebsiella, and 1 Enterobacter sp.
Statistical Analysis Sensitivity, specificity, negative, and positive predictive values of CRE screening by HiCrome KPC agar were found to be 100% (91.4–100), 91.9% (84.8–95.8), 83.6% (70.9–91.4), and 100% (95.9–100), respectively, taking the CDC recommended method as reference.
Conclusion HiCrome KPC agar has high sensitivity in screening CRE colonization. Further studies are needed to establish its applicability for detecting the predominant circulating carbapenemases in the Indian setting.
Strength- and recovery-based approaches in forensic mental health in late modernity: Increasingly incorporating a human rights angle?
Authors: Tomlin Jack , Jordan Melanie 
Published: July 2021

AbstractForensic mental health care is situated across both criminal justice and healthcare systems and is subject to political, cultural, legal and economic shifts in these contexts. The implementation of strength- and recovery-based models of care should be understood in light of these social and structural processes. Drawing on novel empirical fieldwork and the extant literature, we argue that full realisation of strength- and recovery-based principles is at odds with aspects of late modern social control. Not wholly compatible, we highlight how concepts of empowerment, autonomy, identity and connectedness can unhelpfully rub-up against the concepts of punitiveness, otherness and risk management. Conceptually this is problematic, but in frontline forensic psychiatry settings, this has real lived-experience detrimental effects for patients – as our data demonstrate. To address this, a human rights approach might be fruitful. Grounding arguments for strength- and recovery-based principles in the heuristic framework of human rights can offer a set of common values to stimulate reform in forensic mental healthcare. The right to respect for private and family life, home and correspondence under Article 8 of the European Convention on Human Rights and Fundamental Freedoms offers a particularly promising, robust and well-defined framework for these future changes – as we outline.
A preliminary study of science diplomacy networks in Central, Eastern and South-Eastern Europe
Authors: Arnaldi Simone , Lombardo Alessandro , Tessarolo Angela 
Published: July 2021

AbstractScience diplomacy (SD) is an emerging field of study at the intersection of international relations and science policy. Despite such a growing interest, the region of Central, Eastern and South-Eastern Europe has received limited attention by the scholars studying this increasingly significant topic. This article presents the preliminary results of a research focusing on international scientific collaborations between the countries that are members of the Central European Initiative (CEI), an intergovernmental forum for regional cooperation spanning across this broad region of Europe. Using social network analysis (SNA), the paper explores which countries are the most prominent in these cooperation networks and whether the countries sharing EU membership are clustered into separate, distinct subgroups, with fewer or weaker ties with Non-EU members.
The pragmatism of drawing context networks
Authors: Butt David G. , Moore Alison Rotha , Wu Canzhong , Cartmill John 
Published: July 2021

Abstract
Linguistics has embraced the functional and contextual turn but, when building tools for systematic contextual description, we have not made as much use as we could of our own functional traditions. Rather, we have largely relied on the metaphors of law and rule, which do not adequately capture tensions between consistency and variability in how language and context relate to each other. Our aim in this paper is to show the economy and practicality of representing context as a pathway through a network, drawing on the network technique for mapping systems of grammatical choice introduced by Michael Halliday, and on its application to other linguistic strata first offered by Ruqaiya Hasan. The paper begins by outlining why alternative frameworks are needed for describing context-language relations. We then present a contextual network for one specific domain of the Systemic Functional Linguistic notion of Tenor, namely social distance, and use this to explore how different configurations of features of social distance influence the way that traditions of practice are passed on as a specialised legacy in two different professional collaborations. While the kind of context modelling discussed here is in a very early phase of development compared to phonetic, morphological and grammatical description, it has many advantages: contextual networks are paradigmatic in orientation; they help display and theorise metastability in language; they are “ad hoc” in Firth’s positive sense; and they constitute a proposal to be tested against observed behaviour within specific cultural and situational settings.
Stability and change in the colour lexicon of the Japonic languages
Authors: Huisman John L. A. , van Hout Roeland , Majid Asifa 
Published: July 2021

Abstract
Previous work on colour lexicons focussed on universal patterns in their structure and evolution. We collected new
colour naming data in Japanese and three under-described Ryukyuan languages (Amami, Miyako and Yaeyama) to investigate semantic
variation and change in the colour lexicon of related languages in a modern context. We found several new colour terms (e.g.,
midori and guriin for ‘green’) in the lexicon of Ryukyuan speakers, apparently resulting
from contact with Standard Japanese and English. A comparison of our data with historical data suggests that modern Ryukyuan
colour systems are closer to modern Japanese than they are to their historic pasts. However, we also found that modern-day
Ryukyuan languages are more similar to each other than they are to Japanese. These findings show the scope of semantic changes
that can occur through outside influence and highlight the need for fresh empirical data in the study of semantics in related
languages.
Translating images of Hong Kong in news coverage on BBC Chinese
Authors: Ping Yuan 
Published: July 2021

Abstract
This study investigates how the image of Hong Kong is presented in translated news in the case of the 2014 protests, adopting an imagological approach. The corpus consists of translated news articles on the BBC Chinese website and their English-language source texts from a variety of British press articles published between 28 September and 15 December 2014. The study is a corpus-based critical discourse analysis focusing on aspects of the labelling and semantic prosodies in relation to Hong Kong. It also assesses aspects of image-building, including the selective appropriation of texts for translation, the institutional procedures, and target readership reception, that together contribute to the discursive construction of socio-political images of Hong Kong.