bluuebunny/crossref_metadata_2025_split huggingface dataset:
Allogeneic stem cell transplant recipients admitted to the intensive care unit during the peri-transplant period have unfavorable outcomes—results of a retrospective analysis from a German university hospital
Authors: Garcia Borrega Jorge , Heger Jan-Michel , Koehler Philipp , Holtick Udo , Hallek Michael , Scheid Christof , Böll Boris , Shimabukuro-Vornhagen Alexander , Kochanek Matthias , Eichenauer Dennis A. 
Published: October 2021

Abstract
The prognosis of allogeneic stem cell transplant recipients admitted to the intensive care unit (ICU) has improved over the last decades. However, data focusing on patients treated in the ICU during the peri-transplant period are scarce. We therefore conducted an analysis comprising 70 patients who had allogeneic stem cell transplantation at the University Hospital Cologne between 2014 and 2020 and were admitted to the ICU between the initiation of conditioning therapy and day 30 after transplantation. The median age was 59 years (range: 18 − 72 years). 50% of patients were female. Sepsis was the most common cause for ICU admission (49%). Mechanical ventilation (MV) was required in 56% of patients, 27% had renal replacement therapy (RRT), and 64% needed vasopressors. The ICU, hospital, 90-day, and 1-year survival rates were 48.6%, 38.6%, 35.7%, and 16.2%, respectively. MV and/or RRT during the ICU stay were associated with an impaired survival (p < 0.0001). The same was true for the use of vasopressors (p < 0.0001). In contrast, baseline characteristics did not impact the outcome. Cardiopulmonary resuscitation (CPR) was performed in 17% of patients. None of the patients undergoing CPR was alive at 1 year. Among patients who died after discharge from the ICU (n = 23), sepsis and other infectious complications represented the major causes of death (48%). Taken together, the present analysis indicates unfavorable outcomes for allogeneic stem cell transplant recipients admitted to the ICU during the peri-transplant period. The data may help to make informed decisions with patients and their families.
adesso: Über das Entwickeln von Software und IT-Unternehmen
Authors: Striemer Rüdiger , von Hayn Andreas 
Published: October 2021

Zusammenfassungadesso ist heute ein internationaler IT-Dienstleister mit über 5000 Mitarbeitenden und Niederlassungen in ganz Deutschland sowie zahlreichen europäischen Ländern. Vor gut 25 Jahren war adesso die Idee von zwei Personen. Die Gründer wollten das wirtschaftliche Potenzial von IT für Unternehmen einfacher nutzbar machen. Von der Ursprungsidee – Prozesse in Softwareentwicklungsprojekten möglich exakt zu modellieren – blieb nicht viel übrig. Was blieb, ist die Leidenschaft für Software. Und ein großer Pragmatismus im Umgang mit Entscheidungen und Problemen. Der Erfolg von Java war entscheidend für den Erfolg des IT-Dienstleisters. Das erste Java-Projekt setzte adesso für Versicherungen um. Auf die Versicherungsindustrie folgten weitere Branchen. Aus reinen Softwareentwicklungsaufträgen wurden häufiger Projekte, in denen Beratung bei der IT-Strategie eine Rolle spielte. Aber im Kern ging es immer darum, wirtschaftliches Potenzial, ausgewiesene Fachleute und die richtigen Technologien zusammenzubringen. Eine der Herausforderungen für adesso ist das Managen des Wachstums. So ist das Finden geeigneter Expertinnen und Experten ein zentrales Thema. Es gilt, Menschen an Bord zu holen, die Fachwissen mitbringen und den adesso-Stil zu schätzen wissen.
Selection and evaluation of preoperative systemic inflammatory response biomarkers model prior to cytoreductive nephrectomy using a machine-learning approach
Authors: Laukhtina Ekaterina , Schuettfort Victor M. , D’Andrea David , Pradere Benjamin , Quhal Fahad , Mori Keiichiro , Sari Motlagh Reza , Mostafaei Hadi , Katayama Satoshi , Grossmann Nico C. , Rajwa Pawel , Karakiewicz Pierre I. , Schmidinger Manuela , Fajkovic Harun , Enikeev Dmitry , Shariat Shahrokh F. 
Published: October 2021

Abstract
Introduction
This study aimed to determine the prognostic value of a panel of SIR-biomarkers, relative to standard clinicopathological variables, to improve mRCC patient selection for cytoreductive nephrectomy (CN).

Material and methods
A panel of preoperative SIR-biomarkers, including the albumin–globulin ratio (AGR), De Ritis ratio (DRR), and systemic immune-inflammation index (SII), was assessed in 613 patients treated with CN for mRCC. Patients were randomly divided into training and testing cohorts (65/35%). A machine learning-based variable selection approach (LASSO regression) was used for the fitting of the most informative, yet parsimonious multivariable models with respect to prognosis of cancer-specific survival (CSS). The discriminatory ability of the model was quantified using the C-index. After validation and calibration of the model, a nomogram was created, and decision curve analysis (DCA) was used to evaluate the clinical net benefit.

Results
SIR-biomarkers were selected by the machine-learning process to be of high discriminatory power during the fitting of the model. Low AGR remained significantly associated with CSS in both training (HR 1.40, 95% CI 1.07–1.82, p = 0.01) and testing (HR 1.78, 95% CI 1.26–2.51, p = 0.01) cohorts. High levels of SII (HR 1.51, 95% CI 1.10–2.08, p = 0.01) and DRR (HR 1.41, 95% CI 1.01–1.96, p = 0.04) were associated with CSS only in the testing cohort. The exclusion of the SIR-biomarkers for the prognosis of CSS did not result in a significant decrease in C-index (− 0.9%) for the training cohort, while the exclusion of SIR-biomarkers led to a reduction in C-index in the testing cohort (− 5.8%). However, SIR-biomarkers only marginally increased the discriminatory ability of the respective model in comparison to the standard model.

Conclusion
Despite the high discriminatory ability during the fitting of the model with machine-learning approach, the panel of readily available blood-based SIR-biomarkers failed to add a clinical benefit beyond the standard model.
First experiences with the Spectrum Compact CE System
Authors: Burgardt Nastasja , Weissenberger Melanie 
Published: October 2021

AbstractThe newly released Spectrum Compact CE System by Promega is a capillary electrophoresis instrument developed for DNA-fragment separation and sequencing. In this study, its compatibility to 8 commercial short tandem repeat (STR) kits from 4 different manufacturers, reproducibility (sizing precision, accuracy and concordance) and robustness (sensitivity and mixture resolution) were tested and compared to the ABI PRISM® 310 Genetic Analyzer. The instrument was able to successfully analyse amplicons of all tested kits, proved to be as precise as claimed by manufacturer specifications and was shown to be more robust than the ABI PRISM® 310 Genetic Analyzer in some aspects. Analyses on the Spectrum Compact CE System were able to resolve peaks with length differences of 1-basepair in the short and long fragment range and mixtures of mixture ratios down to 1:30. We describe the advantages and limitations we have observed so far working with this instrument in our forensic genetics laboratory.
Sensory equipment and adaptations to the fire habitat of the antennae of the Australian ´firebeetle´ Merimna atrata (Coleoptera; Buprestidae)
Authors: Schmitz Anke , Schmitz Helmut 
Published: October 2021

AbstractThe ‘Australian firebeetle’ Merimna atrata approaches fires in Eucalyptus forests for reproduction. Beetles stay on a postfire area as long as burning wood or hot ashes emit heat and smoke. Abdominal infrared receptors protect the beetles from landing on hot spots; however, until now fire-specific adaptations of the antennae have not been investigated in more detail. This affects the localization of olfactory sensilla used for the perception of smoke and in addition mechanisms to protect delicate sensilla against desiccation and pollution. Moreover, nothing was known about antennal thermo-/hygroreceptors in Merimna atrata. We found strong evidence for a functional grouping of the sensilla into receptors used on the ground or in flight, respectively. A first group comprises the outer visible sensilla, i.e. mechanosensory bristles, short gustatory sensilla and a small field of very short olfactory sensilla. They are used when the beetle is running around on the fireground on burnt bark or ashes. A second group of sensilla is hidden in closeable cavities on antennomeres 4–11. If the cavities are closed, the sensilla inside are fully protected. If the cavities are opened in flight, the beetles can make use of many multiporous basiconic sensilla and multiporous basiconic grooved peg sensilla for smoke detection. Minute modified sensilla coelocapitula occurring in small numbers in the cavities too, most probably serve as thermoreceptors. As a result the placing of sensilla deserving protection in closeable cavities and the reduction in number and length of the external sensilla can be interpreted as adaptations to the fire habitat.
Ongoing Fen–Bog Transition in a Boreal Aapa Mire Inferred from Repeated Field Sampling, Aerial Images, and Landsat Data
Authors: Kolari Tiina H. M. , Sallinen Antti , Wolff Franziska , Kumpula Timo , Tolonen Kimmo , Tahvanainen Teemu 
Published: October 2021

AbstractNorthern aapa mire complexes are characterized by patterned fens with flarks (wet fen surfaces) and bog zone margins with Sphagnum moss cover. Evidence exists of a recent increase in Sphagnum over fens that can alter ecosystem functions. Contrast between flarks and Sphagnum moss cover may enable remote sensing of these changes with satellite proxies. We explored recent changes in hydro-morphological patterns and vegetation in a south-boreal aapa mire in Finland and tested the performance of Landsat bands and indices in detecting Sphagnum increase in aapa mires. We combined aerial image analysis and vegetation survey, repeated after 60 years, to support Landsat satellite image analysis. Aerial image analysis revealed a decrease in flark area by 46% between 1947 and 2019. Repeated survey showed increase in Sphagnum mosses (S. pulchrum, S. papillosum) and deep-rooted vascular plants (Menyanthes trifoliata, Carex rostrata). A supervised classification of high-resolution UAV image recognized the legacy of infilled flarks in the patterning of Sphagnum carpets. Among Landsat variables, all separate spectral bands, the Green Difference Vegetation Index (GDVI), and the Automated Water Extraction Index (AWEI) correlated with the flark area. Between 1985 and 2020, near-infrared (NIR) and GDVI increased in the central flark area, and AWEI decreased throughout the mire area. In aapa mire complexes, flark fen and Sphagnum bog zones have contrasting Landsat NIR reflectance, and NIR band is suggested for monitoring changes in flarks. The observed increase in Sphagnum mosses supports the interpretation of ongoing fen–bog transitions in Northern European aapa mires, indicating significant ecosystem-scale changes.
Constrained Naïve Bayes with application to unbalanced data classification
Authors: Blanquero Rafael , Carrizosa Emilio , Ramírez-Cobo Pepa , Sillero-Denamiel M. Remedios 
Published: October 2021

AbstractThe Naïve Bayes is a tractable and efficient approach for statistical classification. In general classification problems, the consequences of misclassifications may be rather different in different classes, making it crucial to control misclassification rates in the most critical and, in many realworld problems, minority cases, possibly at the expense of higher misclassification rates in less problematic classes. One traditional approach to address this problem consists of assigning misclassification costs to the different classes and applying the Bayes rule, by optimizing a loss function. However, fixing precise values for such misclassification costs may be problematic in realworld applications. In this paper we address the issue of misclassification for the Naïve Bayes classifier. Instead of requesting precise values of misclassification costs, threshold values are used for different performance measures. This is done by adding constraints to the optimization problem underlying the estimation process. Our findings show that, under a reasonable computational cost, indeed, the performance measures under consideration achieve the desired levels yielding a user-friendly constrained classification procedure.
Quality of life impairment in adult Moyamoya patients—preoperative neuropsychological assessment and correlation to MRI and H215O PET findings
Authors: Haas Patrick , Fudali Monika , Wang Sophie S. , Hurth Helene , Hauser Till-Karsten , Ernemann Ulrike , Tatagiba Marcos , Khan Nadia , Roder Constantin 
Published: October 2021

AbstractMoyamoya angiopathy (MMA) related cerebral perfusion deficits or infarctions might influence quality of life (QoL). This study examines preoperative QoL in adult patients with MMA and correlates these with findings obtained via diagnostic imaging. Sixty-seven adult Moyamoya patients underwent preoperative neuropsychological testing including questionnaires to determine QoL, as well as psychiatric and depressive symptoms. The results were checked for correlation with territorial hypoperfusions seen in H215O PET with acetazolamide (ACZ) challenge (cerebrovascular reserve) and infarction patterns observed in MRI. Each vascular territory was analyzed separately and correlated with QoL. Physical role function was restricted in 41.0% of cases and emotional role function in 34.4% of cases (SF-36). Obsessive–compulsive disorder (39.3%) (SCL-90-R), psychoticism (34.4%) (SCL-90-R), and depression (32.7%) (BDI-II) were also very common. Psychoticism was significantly more frequent in cases where perfusion deficits in PET CT were observed in both MCA territories (left p = 0.0124, right p = 0.0145) and infarctions in MRI were present in the right MCA territory (p = 0.0232). Depression was significantly associated with infarctions in the right MCA territory (SCL-90-R p = 0.0174, BDI-II p = 0.0246). Women were affected more frequently by depression (BDI-II, p = 0.0234). Physical role function impairment was significantly associated with perfusion deficits in the left MCA territory (p = 0.0178) and infarctions in the right MCA territory (p = 0.0428). MMA leads to impairments in different areas of QoL. Approximately one-third of all adult MMA patients suffered from depression, with women being most affected. In addition to depression, presence of executive dysfunctions and mental disorders such as psychoticism, obsessive–compulsive disorder, and impaired physical and emotional role function affected QoL. These patients showed significantly more often infarctions and perfusion deficits in the right MCA territory. Long-term studies with follow-up results are necessary to clarify a possible beneficial impact of early surgical revascularization on QoL and depression in adult MMA patients.
Motivations behind individuals’ energy efficiency investments and daily energy-saving behavior: The case of China
Authors: Perret J. K. , Udalov V. , Fabisch N. 
Published: October 2021

AbstractThe impact of environmental motivations on the individual’s decisions regarding investments in energy efficiency and the adoption of energy-saving habits are analyzed for a representative sample of Chinese inhabitants from the larger Beijing area, replicating a comparative study on Western Europe. For the considered type of energy efficiency investments and daily energy-saving activities similarities and discrepancies between the two regions are discussed in regard to their sociocultural background as well as governmental regulations. The study provides empirical evidence that for Chinese environmental issues if all only play a tertiary role after monetary and regulatory incentives. The findings could suggest that in China policy programs aimed at raising environmental awareness and forming pro-environmental motivations might not lead to an increase in energy efficiency investments and daily energy-saving activities and the Chinese government’s interests in this regard might be better served by implementing corresponding incentives via regulations. In the long-term. However, social peer pressure might affect a change in the Chinese mentality.
The Refugee Experience of Asylum Seekers in Italy: A Qualitative Study on the Intertwining of Protective and Risk Factors
Authors: De Leo Amalia , Cotrufo Paolo , Gozzoli Caterina 
Published: October 2021

AbstractThis study aims to investigate the criticisms and support factors of the migratory experience of a group of asylum seekers (ASs) hosted in an Italian reception center. Starting from a psychosocial approach that gives importance to the intertwining of the personal history and context, the present study aims to explore the meaning that ASs give to their origins, the relationship of ASs with the host context and with professionals of the refugee centres, along with the representation of the Future. We conducted 27 semi-structured deep interviews with 9 male ASs with an average age of 24,4 years. In line with the research goals, we carried out an analysis of pencil-and-paper content using the interpretative-phenomenological-analysis. Three different types of refugee experience emerged: persecutory, ambivalent and integrated. The three conditions identified can help professionals to better understand the different experiences of ASs, allowing them to develop more effective interventions.
Blameworthiness and the Outcomes of One’s Actions
Authors: Lee Ambrose Y. K. 
Published: October 2021

AbstractThere are at least two ways to argue for the view that the outcome of one’s actions does not affect one’s blameworthiness. The first way appeals to the ‘Control Principle’ while the second way relies on what it means to be blameworthy. The focus of this paper is on a recent attempt at pursuing this second way that relies on an account of blameworthiness dubbed the ‘Engagement View’. This paper argues, however, that the Engagement View alone is insufficient to show why the outcomes of one’s actions does not affect one’s blameworthiness. It argues that if blame is understood more robustly as involving reactive attitudes like resentment and indignation, then it turns out the Engagement View can also give us reasons for the contrary view. This paper ends by drawing out some general implications that this has on our understanding of blameworthiness.
SPReaD: service-oriented process for reengineering and DevOps
Authors: da Silva Carlos Eduardo , Justino Yan de Lima , Adachi Eiji 
Published: October 2021

AbstractThe reengineering of systems into a microservice-based architecture can be seen as an implementation of a service-oriented architecture (SOA). However, the deployment of SOA into an enterprise is a challenging task, as it may involve the modernization of mission-critical systems with high technical debt and high maintenance costs. To this end, a process is required to provide an appropriate set of steps and techniques that minimize risks and at the same time ensure the quality of the systems during the migration process. Thus, this work presents the Service-oriented Process for Reengineering and DevOps—SPReaD, an instantiation of the mainstream SOA methodology focusing on the reengineering of legacy systems integrating DevOps aspects for developing microservices systems. This process has been defined during a real software reengineering project of legacy systems from a Brazilian State Department of Taxation. The results obtained include a substantial improvement in the quality of the main taxation system used by the state, including not only code-related metrics but also performance improvements of the services offered, and a change in the methodology adopted by the software development team.
The reconstruction of Arab women role in media: a critical discourse analysis
Authors: Hamid M. Abdul , Basid Abdul , Aulia Isma Nida 
Published: October 2021

AbstractArab women and the patriarchal culture are two things that cannot be separated. The influence of globalization and the rate of information and the Arab Spring revolution have such a profound impact on the identity of Arab women. The issue of discrimination and emancipation as a manifestation of the effort to re-actualize the identity of Arab women is widely reported in the media that we can see its progress day by day. This study shows how the media represents the identity of Arab women in Midan Al-Jazeera, Al-Ittihad, and mawdoo3 which contain problems in the social life of Arab women. As for the social reality of Arab society, women are positioned as individuals who can begin to actualize themselves. The data were analyzed by combining the concept of critical discourse analysis approach by Norman Fairclough and Teun A. Van Dijk who divided the analysis into three dimensions: text (micro), practical discourse (meso), and sociocultural (macro). The results show that the articles in Arab Media represent the re-actualization of Arab female identity using a specific discursive strategy in each of the articles. Through the texts in the article, Arab women are represented as free individuals, regardless of the role of wife and mother, and to have an active contribution to the social and autonomous sphere. It is under the conservative Arab government agenda toward a more moderate country in the twenty-first century.
Das Übergangstraining
Authors: Wanke Eileen M. , Matt Christopher , Ohlendorf Daniela 
Published: October 2021

ZusammenfassungNeben der Vorbeugung von akuten und chronischen Schäden ist im professionellen Bühnentanz bei gesundheitlichen Problemen am Muskel-Skelett-System eine intensive – dem Berufssport vergleichbare – Rehabilitation unter Berücksichtigung tanzspezifischer Bewegungselemente von großer Bedeutung. In Kombination mit anderen, die Leistungsfähigkeit wiederherstellenden Maßnahmen ist das in diesem Beitrag erläuterte sog. Übergangstraining(„transition dance class“) als Trainingsform im Rahmen der stufenweisen beruflichen Wiedereingliederung von zentraler Bedeutung, da es die Übergangsphase zwischen allgemeinen Maßnahmen einer Rehabilitation und dem Wiedererreichen der vollständigen Arbeitsfähigkeit im Tanzberuf darstellt.