bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMUNODEFICIÊNCIA COMUM VARIÁVEL: RELATO DE CASO
Authors: Moreira Lira Renan , Luiz Quixabeira Camargo Frederico , Pereira da Silva João Batista , Bitencourt Evandro Leite , Cordeiro de Aguiar Jesian , Castro Costa Póvoa Frederico , Franco Ludmila 
Published: December 2021

INTRODUÇÃO: A imunodeficiência comum variável (ICV) é uma condição que inibe a função do sistema imunológico, tornando aqueles com a doença mais suscetíveis à infecção de patógenos externos. O objetivo deste trabalho foi de expor caso de paciente masculino diagnosticado para ICV, delineando as intervenções realizadas, visto que se trata de uma manifestação de características singulares em que diagnóstico é complexo. DESCRIÇÃO: Metodologia utilizada foi a de relato de caso em que se descreveu todos os passos na abordagem do paciente. O ICV é um distúrbio imunológico, com consciência limitada entre os médicos praticantes, especialmente os de atenção primária; uma vez que a condição mimetiza outras doenças imunológicas, é frequentemente mal diagnosticada ou subdiagnosticada, especialmente devido à sua apresentação variável da doença. Não existem critérios padronizados para o diagnóstico, com o mecanismo de atividade da doença mal compreendido. CONCLUSÃO: No caso analisado, o diagnostico diferencial de exclusão foi fundamental para o início do tratamento com reposição de imunoglobulina, conforme preconiza a normatização vigente. Pacientes com ICV requerem uma abordagem específica para a otimização do quadro clínico dos em curto e longo prazo. Eles precisam de avaliações frequentes de especificamente de especialista em doenças infecciosas e imunologista.
The Romantic Concealment of Desire: Coleridge’s and Wordsworth’s Poetic Voices
Authors: Botero Camacho Manuel 
Published: December 2021

The present study poses an interpretation of Samuel Taylor Coleridge’s “The Eolian Harp” and William Wordsworth’s “Lines Written a Few Miles above Tintern Abbey” so as to evince the subject of desire as the ulterior motif of these texts, even though the poetic voices of these works attempt to conceal such a theme. This reading interprets both poems as compositions that share the same thematic line as William Blake’s “The Book of Thel” and John Keats’ “Ode on a Grecian Urn”. Consequently, the close reading of the poems by Wordsworth and Coleridge will be presented.
Casing While Drilling Successfully Implemented for the First Time in High Risk Area of the Bahrain Field
Authors: Aljawder Abdulla Ebrahim , Aljanahi Ahmed Mohamed , Almannai Hassan Ebrahim , Matar Omar Ali , Ali Eyad Mohamed , Aydinak Gokalp , Pincay Andrea , Refai Ahmed Samir , Zayed Zeyad Sameer 
Published: December 2021

Abstract
One known risk of the Awali field is hole collapsing in the surface section due to the presence of floating bloulders and cavities in areas of the field; resulting in wells being abandoned as conventional drilling was not enough to solve this issue. In 2019, Schlumberger and Tatweer Petroleum combined forces to improve production of Ostracod/Magwa shallow reservoirs by drilling wells in new areas of the field which included drilling in locations with offset wells that were abandoned due to hole collapse issues in the first 500’ interval. Drilling campaign started in june 2019 and drilled succesfully two wells, but two others were abandonned due to hole collapse issues. These abandonned wells were in very promising production areas as per the reservoir model and due to the shallowenest of the reservoir, it was not possible to move the surface location. Therefore, the issues in the surface section needed to be solved in order to maximize profits in the country.
Following a rigerous study for determining which is the optimal solution for drilling the surface section in this area of the field, Casing While Drilling (CwD) technology was selected and implemented in August 2019 in well A-1530D, next to the previous abandoned wells. CwD operation was performed with excellent results by drilling from 101ft to 520ft with no issues. CwD successfully isolated the higly problematic zones in the surface section and more importantly, allowed to reach areas of the reservoir that had high potential for production.
Prior Assessment of Variability in the Geotechnical Properties of Soils for Efficient Infrastructure Management
Authors: Dharamapriya P.L. , Jayasena H.A.H. 
Published: December 2021

Abstract
Advance assessments of variations in geotechnical properties of soils are invaluable in making a crucial judgment of geotechnical engineering projects. It could drive to reduce the number of field and laboratory tests so that efficient management design and construction of infrastructure project outputs can be achieved. In this study, we aim at assessing the geotechnical properties of residual, alluvial, marshy, coastal, and compacted soils within the wet and the dry zones of Sri Lanka. Plastic limit (PL), liquid limit (LL), shrinkage limit (SL), plasticity index (PI), liquidity index (LI), compression index (Cc), swell potential (SP), activity, natural moisture content (NMC) and SPT-N values were either extracted from reports or deduced from formulas and graphs. Wet zone marshy soils (My_W) show highest statistical means for PL (~23%), LL (~40%), PI (~16 %), SL (~20 %), LI (~ 1%), Cc (~ 0.200) and NMC (~ 35%), indicating poor engineering properties. Wet zone residual soils (Re_W) represent a wide range of direct correlations to the parent material. CH, OH, CL and SM soil groups for some My_W show high expansive, while, CL, Pt/CL, OL, SC, SM in My_W, CL, and SC in Re_W and CL in Dry Zone Alluvial Soils (Al_D) display medium expansive. The higher SPT-N values were recorded in the upper 6.00m and between 12.00-16.00m for the shell of earth dams (SED_D) in the dry zone, in contrast to Al_D soils representing higher N values for 6.00-12.00m. Except for marshy soils, no vertical variation for plasticity was observed in others. Since high to medium swell potential in the unsaturated zone is encountered within the upper 1.50m, attention should pay to the My_W. LL and PI of My_W were strongly correlated (R2 = 0.83) so that an equation PI% = -1.91 + (0.46*LL%) could be used to calculate PI. The results provide baseline geotechnical property variations for the five soils in Sri Lanka so that during planning, best-calculated assessment could be achieved which could minimize time and cost for crucial geotechnical investigations.
Emergence of climate change signals in marine ecosystem thermal niches
Authors: Santana-Falcón Yeray , Seferian Roland 
Published: December 2021

Abstract
Temperature is one of the most important drivers of global ocean patterns of biodiversity1,2,3 shaping thermal niches through thresholds of physiological thermal tolerance4⁠. Because of anthropogenic global warming, lower and upper thermal niche bounds are predicted to change affecting the future distribution of marine species5,6⁠. Current working hypotheses suggest an expansion of ectotherms toward their poleward boundaries7,8. Nonetheless, the knowledge of the timing and extent of these rearrangements across latitude and depth remains limited. Here, using daily data across the water column from both Ocean Sites network observations and novel Earth System Model, we track the emergence of thermal niches whose lower bound is warmer than their current upper bound, potentially disrupting marine habitats. We show that these developments will emerge by ~2030 in subsurface waters (~50 – 1000 m) if anthropogenic emissions continue to rise, whereas they delay several decades if emissions are substantially reduced. By 2100, thermal niches will be warmer than current counterparts. However, we further show that depending on the vertical level, concomitant changes in both boundaries will result in wider or narrower thermal niches. These results suggest that the redistribution of marine species might differ across depth, shedding light upon a much more complex picture of the impact of climate change on marine habitats.
Observed and Predicted Precipitation Changes in Pakistan Using Ground Observations, Satellite Data and Model Projections with Special Focus on Winter and Pre-Monsoon Precipitation
Authors: Safdar Fasiha , Khokhar Muhammad Fahim , Mahmood Fatimah , Zeeshan Muhammad , Arshad Muhammad 
Published: December 2021

Abstract
This study utilizes ground, satellite and model data to investigate the observed and future precipitation changes in Pakistan. Pakistan Meteorological Department’s (PMD) monthly precipitation data set along with Tropical Rainfall Measuring Mission (TRMM) monthly dataset TRMM_3B43 (0.25˚x0.25˚ resolution) have been used to evaluate rainfall trends over the climatic zones of Pakistan through Man-Kendall test and Sen’s slope estimator for the time period 1978-2018. Community Climate System Model (CCSM4) projections have been employed to explore the projected changes in precipitation till 2099. Furthermore, TRMM and CCSM4 projections have been correlated and validated using Root Mean Square Error (RMSE) and Mean Bias Error (MBE). There is a good correlation between TRMM and PMD ground observation at all stations of the country for all seasons, with correlation coefficient values ranging from 0.89 (November) to 0.97 (July and August). The study shows a decreasing trend in winter precipitation in all zones of the country with a significant decrease over western mountains i.e. zone C of the country. During 2008-2018, a sharp decrease in winter precipitation is observed as compared to the baseline value of 1978-2007 in all climatic zones. There seems to be a shift in precipitation from winter towards pre-monsoon season as pre-monsoon precipitation in last 11 years increased in all zones except Zone C. Coherently, there is a decrease in area affected by winter precipitation and an increase in area for pre-monsoon precipitation. Future precipitation estimates from CCSM4 model for RCP 4.5 and RCP 8.5 over-estimate precipitation in most parts of the country for the first 9 observed years (2010-2018) and predict a rise in precipitation by 2099 which is more pronounced in the northern and western Pakistan while a decrease is predicted for the plains of the country, which might have negative consequences for agriculture.
Effect of Pharmacist Intervention on 30-Adverse Drug Event after Discharge in Elderly Patients through a Comprehensive Medication Reconciliation: A Randomized Clinical Trial
Authors: Lee SunMin , Yu Yun Mi , Han Euna , Park Min Soo , Lee Jung-Hwan , Chang Min Jung 
Published: December 2021

Abstract
Polypharmacy can cause drug-related problems, such as potentially inappropriate medication (PIM) use and medication regimen complexity in the elderly.
This comprehensive medication reconciliation study was designed as a prospective, open-label, randomized clinical trial with patients aged 65 years or older from July–December 2020. Comprehensive medication reconciliation comprises medication reviews based on the PIM criteria. The discharge of medication was simplified to reduce regimen complexity. Changes in regimen complexity were evaluated using the Korean version of the medication regimen complexity (MRCI-K). Adverse drug events (ADEs) were monitored throughout hospitalization and 30 days after discharge. Of the 32 patients, 34.4% (n = 11) reported ADEs before discharge, and 19.2% (n = 5) ADEs were reported at the 30-day phone call. No ADEs were reported in the intervention group, whereas five events were reported in the control group (p = 0.039) on the 30-day phone call. The intervention group showed a greater score reduction than the control group in terms of the number of medications, MRCI-K, and PIMs. As a result of the pharmacist intervention, we identified the feasibility of pharmacist-led interventions using comprehensive medication reconciliation, including the criteria of the PIMs and the MRCI-K, and the differences in ADEs between the intervention and control groups at the 30-day follow-up after discharge (Clinical trial number: KCT0005994, 03/12/2021).
In Vivo Imaging of Mammalian Embryos By NIR-I Photoacoustic Tomography and NIR-II Optical Coherence Tomography Using Gold Nanostars as Multifunctional Contrast Agents
Authors: Zhang Sheng , Liu Zhenyang , Mao Linlin , Wu Jian , Zhang Di , Liu Ruiyuan , Qi Li 
Published: December 2021

Abstract
Background High resolution, strong contrast and multimodality visualization of live mammalian embryo is an important requirement for studying foetal development. Photoacoustic Tomography (PAT) and Optical Coherence Tomography (OCT) are two advanced imaging modalities that has been utilized for embryonic imaging. However, high contrast, multiscale and deep tissue visualization of live embryos remains challenging. Results Here, we demonstrate the use of gold nanostars (GNS) as multimodality contrast agents for the visualization and differentiation of embryos in vivo using NIR-I PAT and NIR-II OCT. We perform NIR-I PAT imaging to confirm in vivo GNS accumulation in the foetuses, and then use a customized NIR-II OCT system to further reveal deep, contrast-enhanced micro features of freshly harvested embryos. We investigate two different GNS administration pathways, i.e. intravenous and intravaginal injection, and significant enhancement of signal, image contrast, and imaging depth are achieved for both PAT and OCT. Conclusions These findings prove that PAT-OCT bi-modal imaging with GNS enhancement provides more accurate structural characteristic of live mammalian embryos, and thus reveal its potential for embryonic development visualization and early abnormality examination. These findings prove that PAT-OCT bi-modal imaging with GNS enhancement provides more accurate structural characteristic of live mammalian embryos, and thus reveal its potential for embryonic development visualization and early abnormality examination.
Fecal Microbiome Modulation of Bacterial Communities Associated With the Administration of Probiotic Lactic Acid Bacteria to Feedlot Cattle
Authors: Mansilla Flavia , Ficoseco Cecilia , Miranda María , Puglisi Edoardo , Nader-Macias Maria Fatima , Vignolo Graciela , FONTANA Cecilia Alejandra 
Published: December 2021

Abstract
Modulation of animal gut microbiota is a prominent function of probiotics to improve the health and performance of livestock. In this study, a large-scale survey to evaluate the effect of lactic acid bacteria probiotics on shaping the fecal bacterial community structure of 126 feedlot cattle during three experimental periods of the fattening cycle (163 days) was conducted. A feedlot industry located in northwestern Argentina was enrolled with cattle fed mixed rations (forage and increasing grain diet). High-throughput sequencing (HTS) of 16S rDNA amplicons was applied to characterize the fecal microbiota and explore its modulation as affected by the administration of five probiotic groups and experimental administration periods. The microbial diversity of fecal samples was significantly affected (p < 0.05) by the administration period compared with probiotic group supplementation. The fecal microbiome of samples was dominated by the Firmicutes (72-98%) and Actinobacteria (0.8-27%) phyla, while a lower abundance of Bacteroidetes (0.08-4.2%) was present. At the family level, probiotics were able to modulate the fecal microbiota with a convergence of Clostridiaceae, Lachnospiraceae, Ruminococcaceae and Bifidobacteriaceae associated with health and growth benefits as core microbiome members. Metabolic functional prediction comparing experimental administration periods showed an enrichment of metabolic pathways related to complex plant-derived polysaccharide digestion as well as amino acids and derivatives during the first 40 days of probiotic supplementation. Genomic-based knowledge on the benefits of autochthonous probiotics on cattle gastrointestinal tract (GIT) microbiota composition and functions will contribute to their selection as antibiotic alternatives for the feedlot industry.
Dissecting extracellular and intracellular distribution of nanoparticles and their contribution to therapeutic response by monochromatic ratiometric imaging
Authors: Yan Yue , Chen Binlong , Yin Qingqing , Wang Zenghui , Yang Ye , Wan Fangjie , Wang Yaoqi , Tang Mingmei , Xia Heming , Chen Meifang , Liu Jianxiong , Wang Siling , Zhang Qiang , Wang Yiguang 
Published: December 2021

Abstract
Efficient delivery of payload to intracellular targets has been identified as the central principle for nanomedicine development, while the extracellular targets are equally important for cancer treatment. Notably, the contribution of extracellularly distributed nanoparticles to therapeutic outcome is far from being understood. Herein, we develop a pH/light dual-responsive monochromatic ratiometric imaging nanoparticle (MRIN), which functions through sequentially lighting up the intracellular and extracellular fluorescence signals by acidic endocytic pH and near-infrared light. Enabled by MRIN nanotechnology, we accurately quantify the extracellular and intracellular distribution of nanoparticles in several tumor models, which account for 65-80% and 20-35% of total tumor exposure, respectively. Given that the majority of nanoparticles are trapped in extracellular regions, we successfully dissect the contribution of extracellularly distributed nanophotosensitizer to therapeutic efficacy, thereby maximize the treatment outcome. Our study provides key strategies to precisely quantify nanocarrier microdistribtion and engineer multifunctional nanomedicines for efficient theranostics.
Healthcare Service Utilization Patterns and Patient Experience in Persons With High Healthcare Needs: A Comparison Across 22 Countries
Authors: Bychkovska Olena , Tederko Piotr , Engkasan Julia Patrick , Hajjioui Abderrazak , Gemperli Armin 
Published: December 2021

Abstract
BackgroundPersons with complex health conditions, e.g. spinal cord injury (SCI), frequently visit numerous clinical settings. Their service utilization and patient experience is a comprehensive indicator of how a system is functioning overall. This study compared the patient experience of persons with chronic SCI in relation to healthcare service utilization patterns in 22 countries, hypothesizing that primary-care oriented patterns would offer better experience.MethodsThis study was based on International Spinal Cord Injury Survey with 12 588 participants from 22 countries worldwide. Utilization clusters were identified by cluster analysis, experience score was attained by partial credit model. The association between the two was explored by regression analysis. ResultsHighest share of visits was to primary care physician (18%) and rehabilitation physician (16%). Utilization patterns had diverse orientation: from primary care to specialized and from inpatient to outpatient. The experience was reported as very good and good across different dimensions: 78% reported respectful treatment; 75% – clear explanations; 71% – involvement in decision making; 63% – satisfaction with care. Average experience score on 0-100-point scale was 64, highest – 74 (Brazil) and lowest – 52 (Japan, South Korea). Service utilization patterns were associated with patient experience, but no uniformly better patient experience was found for neither primary or specialized care-oriented systems. ConclusionWhile there are distinct utilization patterns between countries of how persons with chronic SCI use the healthcare system, neither the more primary care oriented nor the specialized care system leads to a uniformly better patient experience.
A Multi-Stage Model of Cell Proliferation and Death: Tracking Cell Divisions with Erlang Distributions
Authors: Belluccini Giulia , Lopez-Garcia Martin , Lythe Grant , molina-parís carmen 
Published: December 2021

Abstract
Lymphocyte populations, stimulated in vitro or in vivo , grow as cells divide. Stochastic models are appropriate because some cells undergo multiple rounds of division, some die, and others of the same type in the same conditions do not divide at all. If individual cells behave independently, each can be imagined as sampling from a probability density of times to division. The most convenient choice of density in mathematical and computational work, the exponential density, overestimates the probability of short division times. We consider a multi-stage model that produces an Erlang distribution of times to division, and an exponential distribution of times to die. The resulting dynamics of competing fates is a type of cyton model. Using Approximate Bayesian Computation, we compare our model to published cell counts, obtained after CFSE-labelled OT-I and F5 T cells were transferred to lymphopenic mice. The death rate is assumed to scale linearly to the generation (number of divisions) and the number of stages of undivided cells (generation 0) is allowed to differ from that of cells that have divided at least once (generation greater than zero). Multiple stages are preferred in posterior distributions, and the mean time to first division is longer than the mean time to subsequent divisions.
Hypoxic-immune Model Based on Lung Squamous Cell Carcinoma Reveals the Effects of Inflammation and Hypoxia on Drug Resistance, CD8 Cell Depletion and Prognosis
Authors: Sun Kang , Zhang Zhiqiang , Wang Dongqin , Ma Hongyu , Lian Chaoqun , Zhang Jing 
Published: December 2021

Abstract
Background: Lung squamous cell carcinoma (LUSC) is a malignant tumor with high mortality and poor prognosis. More evidence shows that hypoxia and the immune environment play an essential role in cancer progression, but the specific impact on lung squamous cell carcinoma is unclear. This study mainly establishes immune and hypoxia risk models to predict the prognosis of patients and formulates personalized treatment plans for patients according to the specific conditions of hypoxia regulation and immune invasion in high-risk groups. Results: Based on the combined use of multiple data, 380 hypoxia and immune co-related genes (HMGs) were obtained， to establish the risk model of immune and hypoxia. Through the use of comprehensive analysis methods, the model has a high predictive value. The survival rate of the high-risk group is low, and the CD8-T cell depletion factor is widely distributed in high-risk groups. It has a large number of neutrophils and low CD8 cells. In addition, hypoxia, inflammation, and drug resistance-related pathways are also abundant in high-risk groups. We also found that high-risk patients were generally resistant to chemotherapeutic drugs. Finally, we constructed a competing endogenous RNA (CeRNA) network closely related to risk genes, including 9 mRNAs, 10 MicroRNAs (miRNAs), and 16 long non-coding RNAs (lncRNAs). Conclusions:This study specifically analyzed the effects of hypoxia regulation and immune Infiltration on the prognosis of patients. It provided a new idea for patients to improve the prognosis and personalized treatment.