bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cariprazine in therapy of visual hallucinations. Randomized, double-blind placebo-controlled study
Authors: NA Aliyev , ZN Aliyev 
Published: October 2021

Objective: We studied cariprazine in therapy of visual hallucinations with a therapeutic resistance due to traumatic brain injury randomized, double-blind placebo-controlled study manner. Methods: To traumatic brain injury hundred patients (100 all men) whom we studied were under observation in Mental Health Center of the Ministry of Health of the Republic of Azerbaijan from January 2020 to June 2021. The method of randomization was given by lottery []. Each patient was randomized to receive either in agreement of the instruction cariprazine (50 patients) over 5 day in dose 6 mg one times per os in morning after meet for 12 weeks or matched placebo (50 patients) in a double-blind manner. A structured clinical interview, for DSM-5Axis I Disorder, Patient Edition, was used to diagnose according to DSM-5 major or mild neurocognitive disorder due to traumatic brain injury. Results: All patients (50) treated with cariprazine treated participants responded by 12 weeks, versus two of the 50 placebo-treated participants (p<0.001). The most common and problematic side effect in the cariprazine group was not. Conclusions: The authors believe this to be the first double-blind placebo-controlled randomization study to test the efficacy of a cariprazine in the management of in therapy of visual hallucinations with a therapeutic resistance due to traumatic brain injury randomized, double-blind placebo-controlled study manner. They need to be replicated in a larger study group.
MONITORAMENTO DOS PARÂMETROS MICROBIOLÓGICOS DA ÁGUA DE CISTERNAS EM ESCOLAS PÚBLICAS DE POCINHOS
Authors: Barbosa da Silva Aldeni , Dantas da Silva Filho Edmilson , Araújo Bruno Allison , Freire da Silva Jeferson , De Lima Silva e Silva Emmily Tainara , Lima Oliveira Eliane Tâmara , Barbosa Barros Kayan , Gomes Lima de Andrade Samanta , Belmino dos Santos Manuela Luiza , Moreira de Brito Janaina 
Published: October 2021

Esse trabalho teve o objetivo de inspecionar os parâmetros microbiológicos da água de cisternas nas escolas públicas de Pocinhos-PB. As amostras de água destinadas para as análises microbiológicas foram coletadas diretamente das cisternas em garrafas de vidro (500 ml) com boca larga, protegidas com papel laminado, previamente esterilizadas em autoclave a 121 oC, por 30 minutos, e foram encaminhadas para o Laboratório do Centro de Formação Profissional do Instituto Albano Franco de Tecnologia de Couro e de Calçado (CTCC) em Campina Grande/PB. Os parâmetros analisados e os métodos de análises foram: coliformes totais, coliformes termotolerantes, Escherichia coli e bactérias heterotróficas. Por motivos éticos, os nomes das referidas escolas foram mantidos em sigilo, sendo as amostras coletadas nas mesmas, identificadas como amostras 1, 2, 3, 4 e 5. Observou-se que, entre as amostras analisadas, três delas (1, 4 e 5) apresentaram quantidade de coliformes totais, totalmente fora dos limites estabelecidos pela portaria vigente. Todas as amostras apresentaram coliformes termotolerantes. Não se evidenciou a presença de Bactérias heterotróficas. A presença da bactéria E. coli, considerada indicativo de contaminação fecal, foi evidenciada em apenas duas amostras. Conclui-se que todas as amostras estão em desacordo com as recomendações estipuladas pela Portaria do Ministério da Saúde de nº 5, de 28 de setembro de 2017, pois apresentaram coliformes totais, coliformes termotolerantes e/ou E. coli, necessitando, portanto, de tratamento prévio antes de serem fornecidas para consumo humano.
Perbandingan Hasil Belajar Siswa Melalui Penggunaan Media Poster Berbasis PPt Interaktif dan Media Video Animasi pada Muatan IPS Kelas IV di SDN Bunulrejo 02 Malang
Authors: Maysella Yesita Galatia , Nihayati Nihayati , Imam Syaiful 
Published: October 2021

Abstract: This research was conducted with the aim of comparing the learning outcomes between students using PowerPoint-based poster learning media with animated video media in social studies subject class IV material "cultural diversity" at SDN Bunulrejo 02 Malang. This research is a quasi-experimental study with a population of all fourth grade students at SDN Bunulrejo 02 Malang. The sample in this study used a purposive sampling technique with 28 students in class IV A as the control class using PowerPoint-based poster media, while in class IV C, 28 students as an experimental class using animated video media. Data collection techniques in this study used the results of pre-test and posttest, interviews and documentation. The results of the study using the t-test obtained tcount is 6.474 and ttable is 2.005, so that the data with tcount greater than ttable, where Ha is acceptable, and it is concluded that there is a significant comparison of student learning outcomes between the use of poster-based learning media and video learning media. animation on social studies learning material about cultural diversity.
Abstrak: Penelitian ini dilakukan bertujuan guna melihat adanya perbandingan hasil belajar antara siswa yang menggunakan media pembelajaran poster berbasis powerpoint dengan media video animasi pada mata pelajaran IPS kelas IV materi “keragaman budaya” di Sekolah Dasar Negeri Bunulrejo 02 Malang. Penelitian ini merupakan penelitian quasi eksperimental dengan populasi seluruh peserta didik kelas IV SDN Bunulrejo 02 Malang. Sampel dalam penelitian menggunakan teknik purposive sampling dengan kelas IV A sebanyak 28 peserta didik sebagai kelas kontrol yang menggunakan media poster berbasis powerpoint adapun kelas IV C sebanyak 28 peserta didik sebagai kelas eksperimen yang menggunakan media video animasi. Teknik dalam pengumpulan data dalam penelitian menggunakan hasil tes pre-test dan posttest, wawancara serta dokumentasi. Hasil penelitian dengan menggunakan uji-t diperoleh thitung adalah 6,474 dan ttabel adalah 2,005, sehingga data tersebut dengan thitung lebih besar dari ttabel di mana Ha dapat diterima, dan disimpulkan adanya perbandingan hasil belajar peserta didik yang signifikan antara menggunakan media pembelajaran poster berbasis powerpoint dengan media pembelajaran video animasi pada pembelajaran IPS materi keragaman budaya.
Pengembangan Media Bimbingan Kelompok dengan Video dalam Meningkatkan Pemahaman Mengenai Pelecehan Seksual untuk Siswa Sekolah Menengah
Authors: Nafis Nadya Yaniar , Hotifah Yuliati , Atmoko Adi 
Published: October 2021

Abstract: This study aims to develop a media of group guidance service with video to increase the understanding about sexual harassment for junior high school students. In this research and development, researchers develop the products as videos and guidebooks. This study uses the type of research and development that uses the Research and Development model by Borg and Gall. There are steps in this research and development are research and data collection, planning, development of initial product drafts, expert trials, product revisions, field trials and final product revisions. The developed products need to be tested by material experts, media and potential users. In analyzing the results of the expert test and the prospective user test, the researcher used a range of data analysis. The results of the analysis of the material expert test in the form of a feasibility presentation of 3.7 and the results of the analysis of the media expert test in the form of a feasibility presentation of 3.93. Based on the results of the analysis, all of them show that the product developed is very feasible so that it can be used by school counselors.
Abstrak: Penelitian ini bertujuan mengembangkan media layanan bimbingan kelompok dengan video dalam meningkatkan pemahaman mengenai pelecehan seksual untuk siswa sekolah menengah pertama. Pada penelitian dan pengembangan ini, peneliti mengembangkan produk berupa video beserta buku panduannya. Penelitian ini menggunakan jenis penelitian dan pengembangan yang menggunakan model Research and Development oleh Borg and Gall. Adapun langkah dalam penelitian dan pengembangan ini yaitu penelitian dan pengumpulan data, perencanaan, pengembangan draf produk awal, uji coba ahli, revisi produk, uji coba lapangan dan revisi produk akhir. Produk yang dikembangkan perlu dilakukan uji ahli materi, media dan calon pengguna. Dalam menganalisis hasil uji ahli dan uji calon pengguna, peneliti menggunakan analisis data rentangan. Adapun hasil analisis uji ahli materi berupa presentasi kelayakan sebesar 3,7 dan hasil analisis uji ahli media berupa presentasi kelayakan sebesar 3,93. Berdasarkan hasil analisis dari seluruhnya menunjukan bahwa produk yang dikembangkan sangat layak sehingga dapat digunakan konselor sekolah.
Changes in pulmonary microcirculation after COVID-19
Authors: Zolotnitskaya Valentina P. , Titova Olga N. , Kuzubova Nataliya A. , Amosova Olga V. , Speranskaya Aleksandra A. 
Published: October 2021

The endothelium is a tissue most vulnerable to the SARS-CoV-2 virus. Systemic endothelial dysfunction leads to the development of endothelitis which causes the main manifestations of the disease and systemic disturbance of microcirculation in various organs. Pulmonary microcirculatory damage, the most striking clinical manifestation, was the reason to perform SPECT to detect microcirculation disorders.Aim. To assess microcirculatory changes in the lungs of patients who had no previous respiratory diseases and had a COVID-19 infection at different times from the onset of the disease.Methods. SPECT data were analyzed in 136 patients who had a proven coronavirus infection of varying severity from May 2020 to June 2021.Results. All patients showed changes in microcirculation in the lungs in the post-COVID period. The severity of microcirculation disorders had a significant correlation (rs = 0.76; p = 0.01) with the degree of damage to the pulmonary parenchyma and an average correlation (rs = 0.48; p = 0.05) with the timing of the post-COVID period and the degree of residual lesions on CT (rs = 0.49; p = 0.01). The examined patients with persistent clinical complaints had pulmonary microcirculatory lesions, which may indicate the development of vasculitis, at all stages of the post-COVID period. Despite regression of the lesions confirmed by CT in 3 to 6 months after the acute COVID-19 infection, specialists from Russian and other countries report that 30–36% of patients develop pulmonary fibrosis. Similar changes were identified in 19.1% of the examined patients in our study.Conclusion. Microcirculation disorders are detected in all patients in the post-COVID period, irrespective of the severity according to CT. Progressive decrease in microcirculation in the lower parts of the lungs, local zones of hypoperfusion with the critically low accumulation of radiopharmaceuticals, persistent areas of compaction of the lung tissue (so-called “ground glass”), reticular changes, and the development of traction bronchiectasis, a decrease in the diffusion capacity of the lungs and alveolar volume may indicate fibrotic lesions with subsequent development of virus-associated interstitial lung disease.
Effectiveness of inhaled corticosteroids and long-acting β-agonists combinations in real clinical practice: results of a multicenter cross-sectional study in Russian patients with asthma
Authors: Arkhipov Vladimir V. , Aisanov Zaurbek R. , Avdeev Sergey N. 
Published: October 2021

Asthma management approaches are improving yearly, but the problem of asthma control is still acute. Combinations of inhaled glucocorticosteroids (ICS) and long-acting β2-agonists (LABA) play a crucial role in asthma therapy, but their effectiveness in real practice can be insufficient, and asthma control level in the population remains low. Optimizing the use of these drugs, changing the usual therapy regimens, and implementing upgraded inhalers can improve adherence to treatment and inhalation technique, which affects the effectiveness of the therapy.The study aimed to describe the key characteristics of the patient population getting asthma treatment in real clinical practice and assess factors influencing asthma control, including adherence to therapy.Methods. A single-stage cross-sectional observational study in 124 primary health care centers in 22 cities of the Russian Federation included 3,214 patients > 18 years old, with a clinical diagnosis of asthma for at least 1 year, who were able to perform a spirometry test and fill out the ACQ-5 and TAI-12 questionnaires.Results. Assessment of asthma control with the ACQ-5 questionnaire showed that most patients had uncontrolled asthma (56%). Controlled and partially controlled asthma was diagnosed in 21 and 19% of patients, respectively. 4% of patients had severe uncontrolled asthma. The TAI questionnaire revealed low adherence to therapy in more than half of the patients (53.6%). The rate of patients with controlled asthma and the average annual frequency of exacerbations were significantly lower in subgroups of patients who received therapy with extrafine ICS/LABA and ICS/formoterol in single inhaler regimen, compared with controller therapy using fixed and free combinations of ICS and LABA.Conclusion. The main causes of insufficient asthma control are low adherence to treatment, inhalation errors, monotherapy with ICS, asthma with small airways dysfunction, and adverse events associated with ICS. Prescribing the combinations of ICS/LABA in the form of extra-fine aerosol and using it in the Maintenance and Reliever Therapy (MART) regimen can significantly increase asthma control, reduce the risk of adverse events, and increase patient adherence to treatment. A potential alternative to improve asthma control is administering ICS-LABA combinations once daily.
Importance of antiviral H₂S in treatment protocols for COVID-19
Authors: Van Hezik Ed. J. 
Published: October 2021

Aim. To propose a new type of antiviral treatment for COVID-19, pending the rollout of the developed vaccines and bypassing vaccine resistance of the new upcoming mutated virus variants. Aiming for prophylaxis and early therapy, the search focused on small molecules or repurposed, safe, oral and inexpensive drugs, also suitable for low-income countries.Methods. A search in peer-reviewed literature for preclinical antiviral mechanisms highlighted at last two clinical studies for further detailed clinical analysis: 1) High dose N-acetylcysteine (NAC) was successfully applied in very severe COVID-19-pneumonia; 2) The discovery of serum level H2S (hydrogen sulfide) as a prognostic host factor.Results. Combining of these two findings resulted in a step-by-step approach with 3 perspectives that describes how H2S works in viral respiratory diseases, how H2S targets at least three vulnerabilities in the SARS-CoV-2 virus; finally, how H2S can be generated and with which drugs. More than 3 dozen successful, clinically well-documented applications have already been found.Conclusion. By using NAC as the H2S donor, the generated endogenous antiviral H2S reactivates the collapsed innate immunity, providing a therapy regimen for COVID-19. Further randomized controlled trials are warranted, considering antiviral H2S for inclusion in some master trial protocols.
Benefit/risk ratio profile of single inhaler triple therapy for сhronic obstructive pulmonary disease patients
Authors: Ovcharenko Svetlana I. , Belevskiy Andrey S. 
Published: October 2021

Chronic obstructive pulmonary disease (COPD) is associated with significant healthcare and socioeconomic burden. International guidelines recommend a personalized approach to treatment and management that aims to reduce symptom burden and exacerbation risk. Numerous recently published clinical trials have investigated efficacy and safety of single-inhaler triple therapy (SITT) with a long-acting muscarinic antagonist (LAMA), long-acting β2-agonist (LABA), and an inhaled corticosteroid (ICS) for patients with COPD.Aim of the publication: to review the findings of randomized controlled trials that showed the benefit of single-inhaler triple therapy and compare this benefit with the known risk of pneumonia associated with ICSs.Conclusion. The key benefits reported with SITT are significant reductions in exacerbations and hospitalizations; the trials also suggest reduced all-cause mortality. The benefits of SITT outweigh the known risk of pneumonia with ICS use that is reported as the class-effect in COPD patients.
Spontaneous gastric perforation in a 3 year old male child – A case report
Authors: Barolia Dinesh Kumar , Singh Aditya Pratap , Bathia Harsha Vinod , Parmar Vipal H , Mehta Bhavana Asit , Mehta Shraddha 
Published: October 2021

spontaneous gastric perforation in paediatric patients beyond the neonatal age is seldom to seen by paediatric surgeon. Therefore we are sharing this case with enlisting the previously reported similar cases in English literature. a three year old male child presented with abdominal distension and hypovolemic shock. Free gas under diaphragm was explained the perforation and exploration confirm the gastric perforation. spontaneous gastric perforation is extremely rare in paediatric age group beyond the neonatal age group, but incidence probability is always there. So, each laparotomy needed exploration of stomach also.
Evaluation of the Preventive Effects of Carvedilol on Trastuzumab-Induced Cardiotoxicity in Early-Stage and Locally Advanced HER2-Positive Breast Cancer Patients
Authors: Esfandbod Mohsen , Naderi Mina , Sadatnaseri Azadeh , Ahmadi Ayat , Noroozi Mohammadtaghi , Sadeghi Joni Saeid 
Published: October 2021

Background: Trastuzumab is an efficient monoclonal antibody used in the treatment of Her2-positive breast cancer. Despite its prominent effect on Her2-positive patients’ disease-free Survival. Trastuzumab-induced cardiotoxicity is still one of the main challenges. Angiotensin-converting enzyme inhibitors (ACE inhibitors) are one of the most potent agents used in heart failure, which also showed confirmed cardioprotective effects against anthracycline and doxorubicin. We aimed to assess the cardioprotective effects of Carvedilol in a randomized clinical trial study.
Materials and Methods: sixty non-metastatic Her-2 positive patients (30 cases; 30 controls) were entered into the study via a simple randomization method.Carvedilol was administered for the patients with the starting dose of 3.125 mg twice a day and started 7 days before trastuzumab administration. The dose has been increased in a three-week period to reach 12.5 mg twice a day and continued until the end of therapy. All the patients underwent an echocardiography after receiving Adriamycin and Cyclophosphamide in order to measure basal Ejection Fraction (EF) and Pulmonary Artery Pressure (PAP). Each patient underwent a follow-up echocardiography in 3,6,9 and 12 months after initiation of the treatment. Finally, all the patients went through the last episode of echocardiography 1 month after the end of treatment. All the Measured PAP and EF has been recorded and analyzed
Results: EF and PAP changes for both groups had no significant changes during the course of treatment with Trastuzmab (p-value = 0.628 and p-value = 0.723, respectively). Seven patients in the intervention group and 2 patients in the control group presented with EF decrease. Also, 8 patients in the intervention and 9 patients in the control groups showed PAP increase.
Conclusion: According to our results, in patients with HER2-positive breast cancer treated with trastuzumab, Carvedilol showed no significant protective effect on trastuzumab-induced cardiotoxicity.
Survival of Post-Transplant Lymphoproliferative Disorder after Kidney Transplantation in Patients under Rapamycin Treatment
Authors: Ashrafi Farzaneh , Shahidi Shahrzad , Mehrzad Valiollah , Mortazavi Mojgan , Hosseini Sayyideh Forough 
Published: October 2021

Background: One of the important causes of mortality and morbidity in kidney transplanted patients is Post Transplant Lymphoproliferative Disease (PTLD), which is due to immunosuppression therapy and viral activity. It seems that Rapamycin, with dual antineoplastic and immunosuppressive effects, may have a pivotal role in the treatment of PTLD patients and preserving transplanted kidneys.
Methods and Materials: Twenty patients with PTLD were enrolled. Immunosuppressive therapy was reduced or ceased, and Rapamycin was initiated at the time of PTLD diagnosis. We evaluated the effects of switching immunosuppressive drugs to Rapamycin on graft status, the response of tumor, and 6, 12 months, and 5-year survival in patients.
Results: PTLD remission was achieved in 14 patients, while six patients died; no relapse was detected in recovered patients. The median of PTLD free time was 25 months, and the mean overall survival in patients with PTLD treated by Rapamycin was 84.8 (95% CI=61.3-108.23).The five-year survival rate was 67%, 12 months survival was 73.8%, and six months' survival was 80%. The response rate to Rapamycin and immunosuppression reduction alone was 46.6%. Four out of 13 Diffuse Large B-Cell Lymphoma patients achieved a complete response just only after the reduction of immunosuppressive drugs and the consumption of Rapamycin.
Conclusion: The present study demonstrated the effectiveness of conversion from immunosuppressive medication, particularly of Calcineurin inhibitors to Rapamycin in PTLD patients. However, more research is needed to confirm the Rapamycin effect on patients with PTLD.
Diversity of Hard Tick Populations and Their Geographical Variations in Northwestern Iran
Authors: Moradi Rohollah , Moradi-Asl Eslam , Telmadarraiy Zakkyeh , Parkhideh Seyedeh Zahra , Rassi Yavar 
Published: October 2021

Background: Ticks are forced vertebrate ectoparasites, including humans, and are vectors of serious diseases such as Crimean Congo Hemorrhagic Fever, Relapsing Fever, and various forms of encephalitis. Spatial assessment of the prevalence of ticks and detection of high risk areas for tick-borne disease transmission and evaluation of ecological measures are key aims of this research.
Methods: Ticks were collected using standard methods from 27 villages in the region of Sarab County in north-eastern Iran during the four seasons of 2018–2019 and identified using valid keys. The calculations of indices for biodiversity were based on the Margalef index, Shannon-Weiner index and Simpson index. R2.15 Statistical software was used for statistical analysis of indices of biodiversity, and ArcMap10.4.1 software, IDW and GeneralG methods were used. Analysis were used to investigate spatial distribution and to determine important tick hotspots.
Results: A total of 2500 animals surveyed, 35% of them were infected. In total, 1416 ticks were caught, 74.6 %, 23.9% and 1.4 % were adult, nymph and larvae respectively. 94% of the ticks were hard ticks including 6 genera. According to the Margalef diversity index, the highest species biodiversity was related to summer (1.4234), and the lowest was relat­ed to winter (0.7379),
Conclusion: Large hotspot area was found in the central part of the study area. The area of study was very prone to tick-borne disease transmission in terms of tick diversity and tick species richness. Tick-borne disease control is an im­portant measure.