bluuebunny/crossref_metadata_2025_split huggingface dataset:
Boesenbergia Pandurata as an Anti-Breast Cancer Agent: Molecular Docking
and ADMET Study
Authors: Pratama Mohammad Rizki  Fadhil , Praditapuspa Ersanda Nurma , Kesuma Dini , Poerwono Hadi , Widiandani Tri , Siswodihardjo Siswandono 
Published: December 2021

Background:
Boesenbergia pandurata or fingerroot is known to have various pharmacological
activities, including anticancer properties. Extracts from these plants are known to inhibit the growth of
cancer cells, including breast cancer. Anti-breast cancer activity is significantly influenced by the inhibition
of two receptors: ER-α and HER2. However, it is unknown which metabolites of B. pandurata play
the most crucial role in exerting anticancer activity.

Objective:
This study aimed to determine the metabolites of B. pandurata with the best potential as ER-α
and HER2 inhibitors.

Method:
The method used was molecular docking of several B. pandurata metabolites to ER-α and
HER2 receptors, followed by an ADMET study of several metabolites with the best docking results.

Results:
The docking results showed eight metabolites with the best docking results for the two receptors
based on the docking score and ligand-receptor interactions. Of these eight compounds, compounds 11
((2S)-7,8-dihydro-5-hydroxy-2-methyl-2-(4''-methyl-3''-pentenyl)-8-phenyl-2H,6H-benzo(1,2-b-5,4-
b')dipyran-6-one) and 34 (geranyl-2,4-dihydroxy-6-phenethylbenzoate) showed the potential to inhibit
both receptors. Both ADMET profiles also showed mixed results; however, there is a possibility of further
development.

Conclusion:
In conclusion, the metabolites of B. pandurata, especially compounds 11 and 34, can be
developed as anti-breast cancer agents by inhibiting ER-α and HER2.
2-Substituted Benzoxazoles as Potent Anti-Inflammatory Agents:
Synthesis, Molecular Docking and In vivo Anti-Ulcerogenic Studies
Authors: Hamid Iqra , Nadeem Humaira , Ansari Sameen Fatima , Khiljee Sonia , Abbasi Inzamam , Bukhari Asma , Arif Muazzam , Imran Muhammad 
Published: December 2021

Background:
Non-steroidal anti-inflammatory drugs (NSAIDs) are the commonly used
therapeutic interventions of inflammation and pain that competitively inhibit the cyclooxygenase
(COX) enzymes. Several side effects like gastrointestinal and renal toxicities are associated with the
use of these drugs. The therapeutic anti-inflammatory benefits of NSAIDs are produced by the inhibition
of COX-2 enzymes, while undesirable side effects arise from the inhibition of COX-1 enzymes.

Objectives:
In the present study, a new series of 2-substituted benzoxazole derivatives 2(a-f) and 3(ae)
were synthesized in our lab as potent anti-inflammatory agents with outstanding gastro-protective
potential. The new analogs 2(a-f) and 3(a-e) were designed depending upon the literature review to
serve as ligands for the development of selective COX-2 inhibitors.

Methods:
The synthesized analogs were characterized using different spectroscopic techniques
(FTIR, 1HNMR, 13CNMR) and elemental analysis. All synthesized compounds were screened for
their binding potential in the protein pocket of COX-2 and evaluated for their anti-inflammatory
potential in animals using the carrageenan-induced paw edema method. Further 5 compounds were
selected to assess the in vivo anti-ulcerogenic activity in an ethanol-induced anti-ulcer rat model.

Results:
Five compounds (2a, 2b, 3a, 3b and 3c) exhibited potent anti-inflammatory activity and
significant binding potential in the COX-2 protein pocket. Similarly, these five compounds demonstrated
a significant gastro-protective effect (**p<0.01) in comparison to the standard drug, Omeprazole.

Conclusion:
Depending upon our results, we hypothesize that 2-substituted benzoxazole derivatives
have excellent potential to serve as candidates for the development of selective anti-inflammatory
agents (COX-2 inhibitors). However, further assessments are required to delineate their underlying
mechanisms.
Adherence to Personal Protective Equipment Against Infectious Diseases Among Healthcare Workers in Arak-Iran
Authors: Harorani Mehdi , Ghaffari Kazem , Jadidi Ali , Hezave Ali Khanmohamadi , Davodabadi Fahimeh , Barati Niloofar , Amini Saeed 
Published: December 2021

Background:
Occupational exposure to blood and body secretions poses a significant risk of COVID-19, HIV, HCV, and HBV among healthcare workers (HCWs). Assessment of this exposure is necessary for optimized planning and policy-making measures. This study aimed to assess the exposure to occupational risk factors among emergency HCWs.

Methods:
This cross-sectional study was performed on HCWs working in 3 educational hospitals affiliated with Arak University of Medical Sciences. The study sample included all HCWs working in emergency wards who met inclusion criteria. The data were collected using a valid and reliable researcher-made questionnaire and analyzed through analytical tests in SPSS software.

Results:
The 116 studied HCWs included 97 nurses and 19 physicians and medical specialties. The mean age was 31.06 with 4.7 years of work experience (207.8 hours per month) in working at the patient bedside. The results indicated that needlestick injuries have a significant positive and negative relationship with job history (p=0.001) and month-averaged working hours (p=0.012), respectively. 96.6% stated that wearing gloves is not necessary, 59.9% stated that they do not use protective glasses due to a decrease in their vision, while 50% did not use gowns due to the lack of gowns in the ward. 63.8%, 57.8%, 50%, 63.8%, 56% and 54.3% of the participants expressed shift work, a high number of hospitalized patients in the crowded ward, the need for high-speed working, high working load, an increase in working hours, and low working consent as the most important factors leading to an increment in blood transmitted diseases, respectively.

Conclusion:
It is necessary to design national surveillance systems to report exposed cases and develop measures and strategic plans considering the high effects of exposure to blood and body secretions.
Effectiveness of Cognitive Behavioural Therapy for Suicide in
Schizophrenia: A Systematic Review
Authors: Penadés Rafael , Forte Florencia , Mezquida Gisela , González-Rodríguez Alexandre , García-Rizo Clemente , Catalán Rosa , Bernardo Miguel 
Published: December 2021

Background:
Suicide is probably one of the worst potential complications
for people with schizophrenia. Even though the use of antipsychotic medication
is essential in reducing suicidal behaviour, the use of psychological treatments
seems to be in the same way necessary. Cognitive Behavioural Therapy
(CBT) is an evidence-based form of psychotherapy that is constantly trying to
synchronise with the latest recommendations from the research. The goal of the
present work is to systematically review the scientific evidence from published
studies testing the effectiveness of CBT designed to deal with suicide in patients
with schizophrenia.

Methods:
We searched using multiple terms related to suicide prevention based
on CBT in schizophrenia. Two databases (Medline and SCOPUS) were scrutinised
for the electronic search, and different reference lists from previous reviews
were also hand-checked.

Results:
We identified 5 randomised and controlled trials of CBT that included
suicide-related cognitions or behaviours as a primary outcome measure. CBT focusing
on suicidal cognitions and behaviours was found to be effective in reducing
suicidal ideation. As the number of studies fulfilling the inclusion criteria is
small, and the assessment of outcomes is heterogeneous, we did not perform a
meta-analysis and present results in a narrative way.

Conclusion:
Research on CBT focused on suicide prevention in patients with
schizophrenia is promising, but current evidence is notoriously insufficient. Although
those therapies seemed to be efficacious in the prevention of suicide,
scarcity of randomised clinical trials specifically focusing on suicide is probably
the most important issue to be faced. Given the current evidence, clinicians
should be familiar with CBT techniques focusing on suicidal cognitions. However,
suicide prevention and treatment in those with schizophrenia is complex, and
many other factors such as possible earlier use of clozapine, optimizing adherence
to medication, and other psychosocial aspects should be addressed. A combination
of different strategies appears to be mandatory.
Нарративы детей Сибири о депортации калмыков. Интервью с В. И. Бадмаевым и А. Н. Овшиновым
Authors:   Kalmyk Scientific Center of the RAS (8, Ilishkin St., 358000 Elista, Russian Federation), Guchinova Elza-Bair M. 
Published: December 2021

Introduction. This publication is devoted to the issues of deportation of the Kalmyk people to Siberia (1943–1956) and the memories that the individuals have of their traumatic experience of the exile period. It consists of an introduction, two interviews, and comments on them. The narratives belong to Kalmyks who were of preschool age at the time of Siberian exile. The purpose of the publication is to focus on “children of Siberia” as a separate generational stratum, with their own specific experiences and loyalties; Siberian villages, sites of their socialization, becoming their homeland. Of relevance are the facts that contribute to the mosaic of the Siberian life of Kalmyks and the stories shedding light on the feelings and experiences of children growing up in Siberia. Also, the author was interested in analyzing the expressions and verbal formulas, plots and associations that create the protagonists’ spontaneous narratives, and the ways the language of trauma, which arises in any narrative of the traumatic event, is used in the material under study. Data and methods. The interviews were taken by the author from V. I. Badmaev (2008) and from A. N. Ovshinov (2018); presented in the form of transcribed texts, these are examined via the method of discourse analysis. Results. The discursive strategies of the two narratives indicate their largely positive character. The author shows that, for their specific exile experience, the “children of Siberia” should be singled out into a separate generational stratum. The material will be of interest to the student of the Kalmyk deportation history and the people’s memory of the exile.
Immunological reactivity of the patient’s body with acute pancreatitis depending on its genesis
Authors: S. I. Ivashchuk  
Published: December 2021

In order to study the features of pathogenesis and pathophysiological mechanisms of the immunological reactivity efficiency of patients with acute pancreatitis, considering the etiological factor, we have examined 189 patients. In patients with biliary pancreatitis immunological reactivity increased by 56,86 % with the reduction of nonspecific antiinfectious by-protection by 47,72 %, while for alcoholic pancreatitis the reduction of activity as nonspecific (by 71,36 %) and specific immune (in 2,35 times) anti-infective defense is observed.
Evaluation of local immunity and level of endogenous intoxication in patients with generalized periodontitis and concomitant chlamydia infection
Authors: O. P. Kobryn  
Published: December 2021

It is defined the differences between the state of non-specific organism’s resistance and the level of endogenous intoxication in patients with generalized periodontitis (GP) and concomitant chlamydia infection. A thorough laboratory examination of 164 patients with GP of I and II stages of chronic course was conducted. To study the protective properties of periodontal tissue, nature of inflammatory response, level of phagocytosis we used the Yasinovskiy’s test (calculated migration of leukocytes in the oral cavity), we determined the concentration of lysozyme and secretory immunoglobulin A levels in oral fluid. In order to determine the overall redox activity of neutrophils we determined the rate of NBT test in peripheral blood and leukocytic intoxication index have been calculated from the results of complete blood count with the help of special formula. Taking into account the results of laboratory examination of patients, we found that the presence of chronic chlamydial infection damages the periodontal tissues greatly. More expressed lesion is confirmed by the increasing number of leukocytes emigration in 1.67 times, desquamation of epithelial cells - 1.25 times), decreased levels of lysozyme in 1.19 times and sIgA - to 1.22 times, the increasing of the level of endogenous intoxication, increasing of the total redox activity of neutrophils compared with those patients without comorbidity.
Influence of insulin resistance on the structural and functional state of myocardium of the left ventricle in males with uncomplicated hypertension
Authors: M. Y. Kolesnyk  
Published: December 2021

The influence of insulin resistance on structural and functional state of the myocardium in 172 males with uncomplicated hypertension has been analyzed. The patients with high insulin resistance (HOMA index was above median) have higher left atrium dimension and tend to concentric remodeling of the left ventricle. Patients with high index HOMA values have echocardiographic signs of increased left ventricle filling pressure after exercise.
Cytokine status and matrix metalloproteinase-9 in patients with cardiorenal syndrome with chronic heart failure and type 2 diabetes
Authors: A. V. Narizhna  , P. G. Kravchun  , N. G. Ryndina  
Published: December 2021

The aim is to assess the existence and nature of the relationship between cytokine status on the basis of the determination of pro-inflammatory IL-1β, anti-IL-10, the functional state of the kidneys and the indicator fibrolysis MMP-9 in patients with CRS against the background of chronic heart failure and 2 diabetes type. The imbalance in the system of cytokines was associated with hyperactivity of antifibrotic factor MMP-9 in patients with CRS with a chronic heart failure and type 2 diabetes as a background. High levels of MMP-9 are involved in disorders of the functional state of kidneys, more pronounced changes in the tubulointerstitial component less - tubular. Study is to determine the prospects predictor’s values of MMP-9 in progress of CRS with the background of CHF and type 2 diabetes.
The ultrastructure of capillaries endotheliocytes in muscular tissue after progenitor fetal liver cells transplantation in patients with chronic limb ischemia
Authors: R. V. Saliutin  , S. S. Palianytsia  , O. V. Buslovych  , V. M. Bogolepov  
Published: December 2021

The failure to perform reconstructive-restorative surgical interventions in distal arterial lesions, justifies the necessity to search and develop indirect methods of revascularization. One of the promising methods is the use of cell transplantation to activate the reparation and angiogenesis processes in the affected limb. The results of carried out preclinical studies with modeled ischemia in laboratory animals have shown significant activation of angiogenesis after transplantation of progenitor fetal liver stem cells. Consequently, the cell transplantation has been performed in patients with chronic limb ischemia. Using the electron microscopy techniques it was proved that at the ultrastructural level of endotheliocytes of capillaries in muscular tissue, cell transplantation contributes to substantial activation of angiogenesis in patients with chronic limb ischemia, and is a promising method of indirect revascularization.
Comparison of plasmapheresis efficacy and complex antioxidant therapy in patients with comorbid course of chronic pancreatitis and chronic obstructive pulmonary disease
Authors: O. S. Khukhlina  , O. O. Ursul  , V. S. Smandych  
Published: December 2021

60 patients with chronic obstructive pulmonary disease (COPD) and chronic pancreatitis (CP) were examined in the dynamics of treatment. The complex therapy of patients with COPD and CP including inhalation therapy with Thiotropium bromide, Serrathiopeptidase and Emoxypin promoted reduced intensity of oxidative stress, restoration of antioxidant protective components activity and natural detoxication system, intensified the activity of enzymatic, Hagemmandependant fibrinolysis and collagenosis, improving the processes of microcirculation, elimination of ischemia and swelling of the pancreatic tissue, quick removal of clinical exacerbation signs of the underlying disease and comorbid diseases. According to the correction degree of enzyme deviation syndrome in the blood, intensity of nitrositic stress and endogenic intoxication in patients with COPD and CP, the effect of 30-day intake of Serrathiopeptidase and 15-day intake of Emoxypin is equal to the efficacy of five plasmapheresis sessions.
The problem of cognitive impairment in neurological practice (reference review)
Authors: T. I. Purdenko  
Published: December 2021

The article presents an analysis of the literature on the problem of cognitive disorders. It is in old age, when vascular and neurodegenerative diseases of the brain are most frequently diagnosed, leading to cognitive disorders of varying severity: from mild to severe. Early diagnosis of cerebral diseases increases significantly the chances of success of treatment to the problem.
New trends in codes of ethics: Czech business ethics preferences by the dawn of COVID-19
Authors: MacGregor Pelikánová Radka , MacGregor Robert Kenyon , Černek Martin 
Published: December 2021

Research background: The morality and sustainability depend upon the active engagement of all stakeholders. Businesses might have to observe minimum standards via their corporate social responsibility (CSR), but this does not imply any mandatory and enforceable requirements for their internal documents. Crises such as the COVID-19 pandemic magnify differences and might impact the perception and commitment to ethics and modify preferences.
Purpose of the article: Since it is up to each and every business whether it will issue Codes of Ethics or Codes of Conduct (Codes) and how they will project ethical principles, values and concerns in them, it is both illuminative and instrumental to conduct a massive theoretical and literature review, to identify five aspects for exploration of Codes: (i) human nature (ii) moral values (iii) ethical principles, (iv) reasoning and (v) sustainability pillars, and to perform such an exploration via a case study at the dawn of the COVID-19 pandemic.
Methods: Based on a massive theoretical and literature review, five aspects for exploration have been identified and employed in a case study involving twenty Codes of the largest Czech businesses, while focusing on their preferences. This is to be achieved by a holistic advanced content analysis employing meta-analysis and manual Delphi method with Likert scoring by a panel of experts.
Findings & value added: The case study reveals that generally Codes prefer (i) Socrates´ perception of human nature, (ii) respect and responsibility as moral values, (iii) the principle of solidarity, (iv) social contract and deontological reasoning and (v) the sustainability social pillar. These findings demonstrate discrepancies and inconsistencies between and also within these Codes, which often paternalistically reject the multi-stakeholder approach that is needed to overcome COVID-19. This litigates for the appropriateness of this new methodology and encourages further longitudinal case studies entailing more jurisdictions and industries.
Evaluation of matrix metalloproteinases and tissue inhibitors of metalloproteinases in aqueous humor of dogs with versus without naturally occurring primary angle-closure glaucoma
Authors: Pumphrey Stephanie A. , Zitek-Morrison Emily , Pizzirani Stefano , Meola Dawn M. 
Published: December 2021

Abstract

OBJECTIVE
To compare concentrations of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in aqueous humor from ophthalmologically normal dogs and dogs with naturally occurring primary angle-closure glaucoma (cPACG).

SAMPLE
Aqueous humor samples from 12 eyes with cPACG and 18 ophthalmologically normal eyes of dogs.

PROCEDURES
A multiplex fluorescence-based ELISA was used to measure concentrations of MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-10, MMP-13, TIMP-1, TIMP-2, and TIMP-4. Results for eyes with versus without cPACG were compared.

RESULTS
Significantly higher mean concentrations of MMP-1 (45% higher), MMP-2 (55% higher), MMP-3 (39% higher), MMP-8 (79% higher), MMP-9 (29% higher), MMP-10 (60% higher), TIMP-1 (63% higher), and TIMP-2 (136% higher) were detected in aqueous humor from eyes with cPACG, compared with ophthalmologically normal eyes.

CLINICAL RELEVANCE
MMPs and TIMPs have pivotal roles in extracellular matrix turnover and homeostasis in the outflow pathways of the eye. Results of the present study documented higher concentrations of MMPs and TIMPs in aqueous humor samples from dog eyes with late-stage cPACG. Although, to our knowledge, TIMPs have not previously been evaluated in the context of cPACG, the markedly higher concentration of TIMPs in eyes with cPACG suggested that inhibition of proteolysis and extracellular matrix turnover might be a factor in the development of glaucoma in susceptible individuals. However, because the present study used samples from dogs with late-stage cPACG, further work is required to characterize the temporal relationship between MMP and TIMP concentration changes and onset or progression of disease.
Outcome of rest with or without bandaging for treatment of carpal flexural contracture deformities in puppies: 47 puppies and 75 joints (2000–2018)
Authors: Petazzoni Massimo , Mortellaro Carlo M. , Esposito Alessandro , Ferrari Francesco , Piras Alessandro , Boudrieau Randy J. 
Published: December 2021

Abstract

OBJECTIVE
To review outcome of dogs with carpal flexural contracture deformities treated with rest alone or with rest and bandaging.

ANIMALS
47 dogs (75 joints).

PROCEDURES
Medical records of dogs with unilateral or bilateral carpal flexural contracture deformities were reviewed, and dogs were grouped according to deformity severity grade (graded on a scale from 1 to 3) at the time of diagnosis. Two treatment groups were compared: rest only and rest with a modified Robert-Jones bandage. All dogs were reevaluated weekly until recovery (ie, resolution of the deformity and lameness).

RESULTS
All dogs responded to conservative management, with all dogs regaining full extension of the antebrachiocarpal joint and ambulating normally at the time of the final visit. Mean ± SD time from initial diagnosis to recovery (ie, resolution of the deformity and lameness) was 2.9 ± 2.2 weeks (median, 2 weeks; range, 1 to 9 weeks). For dogs with grade 1 or 2 severity, mean time to recovery did not differ significantly between treatment groups. For dogs with grade 3 severity, however, mean time to recovery was significantly shorter for dogs treated with rest and bandaging than for dogs treated with rest alone.

CLINICAL RELEVANCE
Results suggested that conservative management (rest alone or rest and bandaging) was a successful treatment option for puppies with carpal flexural contracture deformity and that bandaging resulted in a shorter time to recovery for dogs that were severely affected.