bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trauma quality indicators: internationally approved core factors for trauma management quality evaluation
Authors:   and the WSES Trauma Quality Indicators Expert Panel, Coccolini Federico , Kluger Yoram , Moore Ernest E. , Maier Ronald V. , Coimbra Raul , Ordoñez Carlos , Ivatury Rao , Kirkpatrick Andrew W. , Biffl Walter , Sartelli Massimo , Hecker Andreas , Ansaloni Luca , Leppaniemi Ari , Reva Viktor , Civil Ian , Vega Felipe , Chiarugi Massimo , Chichom-Mefire Alain , Sakakushev Boris , Peitzman Andrew , Chiara Osvaldo , Abu-Zidan Fikri , Maegele Marc , Miccoli Mario , Chirica Mircea , Khokha Vladimir , Sugrue Michael , Fraga Gustavo P. , Otomo Yasuhiro , Baiocchi Gian Luca , Catena Fausto 
Published: February 2021

Abstract
Introduction
Quality in medical care must be measured in order to be improved. Trauma management is part of health care, and by definition, it must be checked constantly. The only way to measure quality and outcomes is to systematically accrue data and analyze them.

Material and methods
A systematic revision of the literature about quality indicators in trauma associated to an international consensus conference

Results
An internationally approved base core set of 82 trauma quality indicators was obtained: Indicators were divided into 6 fields: prevention, structure, process, outcome, post-traumatic management, and society integrational effects.

Conclusion
Present trauma quality indicator core set represents the result of an international effort aiming to provide a useful tool in quality evaluation and improvement. Further improvement may only be possible through international trauma registry development. This will allow for huge international data accrual permitting to evaluate results and compare outcomes.
Trajectories of objectively measured physical activity and mood states in older Japanese adults: longitudinal data from the Nakanojo Study
Authors: Inada Shuji , Yoshiuchi Kazuhiro , Park Sungjin , Aoyagi Yukitoshi 
Published: February 2021

Abstract
Background
Japan, like many developed countries, now faces fiscal problems from the escalating health-care expenditures associated with an aging population. Mental health problems such as depression contribute as much to these growing demands as physical disease, and measures to prevent depression are important to controlling costs. There are few longitudinal studies examining the relation between objectively measured physical activity and depressive symptoms. Therefore, the aims of our study were to explore the patterns of change of physical activity in older Japanese adults for 5 years through the use of trajectory analysis and to examine the relation between physical activity trajectories and depressive mood states.

Main body
Ninety-two male and 99 female volunteers aged 65–85 years were asked to equip themselves with an electronic accelerometer with a 60-day storage capacity for at least 5 years. The parameters calculated each July for the 5 years were the average daily step count and the average daily duration of activity > 3 METs (moderate to vigorous physical activity: MVPA). Hospital Anxiety and Depression Scale (HADS) assessed corresponding mood states (HADS-A and HADS-D). Trajectories of the accelerometer data were analyzed and fifth-year HADS-D and HADS-A scores were compared among trajectory groups using an analysis of covariance (ANCOVA) that controlled for baseline scores and for baseline scores and age. Six and five distinct trajectories were identified for daily step count and for daily duration of MVPA, respectively. Using ANCOVA controlling for baseline scores, HADS-D scores differed significantly among trajectory groups classed by daily duration of MVPA (p = 0.04), and Tukey’s multiple comparison tests showed significant differences between group 2, whose pattern was stable with the middle duration of MVPA, and group 1, whose pattern was stable with the lowest duration of MVPA (p = 0.02), while the results were not significant controlling for both baseline scores and age.

Conclusions
Older people with less MVPA continued to do less MVPA over the 5 years of study, which may be related to a future more depressive mood. Further clinical studies will be necessary to clarify these findings.
Implementing child and youth mental health services: early lessons from the Australian Primary Health Network Lead Site Project
Authors: Oostermeijer Sanne , Bassilios Bridget , Nicholas Angela , Williamson Michelle , Machlin Anna , Harris Meredith , Burgess Philip , Pirkis Jane 
Published: February 2021

Abstract
Aim
Primary mental health care services play an important role in prevention and early intervention efforts to reduce the prevalence and impact of mental health problems amongst young people. This paper aimed to (1) investigate whether mental health services commissioned by Australia’s 31 Primary Health Networks provided accessible care and increasingly reached children and youth across Australia, and (2) identify the challenges of, and facilitating factors to, implementing services for youth with, or at risk of, severe mental illness (i.e., youth enhanced services) in 10 PHNs which acted as mental health reform leaders (i.e., Lead Sites).

Methods
We used mixed methods, sourcing data from: a national minimum data set that captured information on consumers and the services they received via all 31 PHNs from 1 July 2016 to 31 December 2017; consultations with Lead Site staff and their regional stakeholders; and observational data from two Lead Site meetings.

Results
Many children and youth receiving services were male and up to 10% were Aboriginal and/or Torres Strait Islander young people. The majority of young people came from areas of greater disadvantage. For most children and youth receiving services their diagnosis was unknown, or they did not have a formal diagnosis. Both child and youth service uptake showed a modest increase over time. Six key themes emerged around the implementation of youth enhanced services: service access and gaps, workforce and expertise, funding and guidance, integrated and flexible service models, service promotion, and data collection, access and sharing.

Conclusions
Early findings suggest that PHN-commissioned services provide accessible care and increasingly reach children and youth. Learnings from stakeholders indicate that innovative and flexible service models in response to local youth mental health needs may be a key to success.
Cross-sectional study of mental health related knowledge and attitudes among care assistant workers in Guangzhou, China
Authors: Li Jie , Duan Xiao-Ling , Zhong Hua-Qing , Chen Wen , Evans‑Lacko Sara , Thornicroft Graham 
Published: February 2021

Abstract
Background
Care assistant workers (CAWs) are a part of a new pattern of mental health care providers in China and play a significant role in bridging the human resource shortage. CAWs in China mainly include community cadres, community mental health staff, and community policemen. The mental health related knowledge and attitudes of CAWs could influence their mental health care delivery. This study aimed to assess mental health related knowledge and attitudes of CAWs in Guangzhou, China.

Methods
In November 2017, a study was conducted among 381 CAWs from four districts of Guangzhou, China. Participants were assessed using the Perceived Devaluation and Discrimination Scale (PDD), the Mental Health Knowledge Schedule (MAKS), and the Mental illness: Clinicians’ Attitudes (MICA) Scale. Data were analyzed by descriptive statistics, ANOVA, Bonferroni corrections and multivariable linear regression.

Results
The mean scores (standard deviation) of PDD, MAKS and MICA were 36.45 (6.54), 22.72 (2.56), and 51.67 (7.88), respectively. Univariate analyses showed that the older CAWs, community policemen and those who were less willing to deliver care to people with mental illness had significant higher MICA scores when compared with other staff (P < 0.001). Multivariable linear regression showed that after controlling for key variables, care willingness and PDD total score were positively associated with the MICA total score (all P < 0.05), while attitudes on additional items were significant negatively with the MICA total score (all P < 0.01).

Conclusion
These findings suggest negative attitudes towards people with mental disorders among CAWs are common, especially among older staff. Community policemen suggest that they applied stereotypes of “violent mentally ill” people to all people they deal with who have mental disorders. The results also indicate human rights are being paid some attention to now, but need to be further continually improved in the future. Strategies for improving such negative attitudes and reducing the perceived stigma and discrimination should be carried out towards particular staff groups in an anti-stigma programme in Guangzhou, China.
Randomized crossover trial of a modified ketogenic diet in Alzheimer’s disease
Authors: Phillips Matthew C. L. , Deprez Laura M. , Mortimer Grace M. N. , Murtagh Deborah K. J. , McCoy Stacey , Mylchreest Ruth , Gilbertson Linda J. , Clark Karen M. , Simpson Patricia V. , McManus Eileen J. , Oh Jee-Eun , Yadavaraj Satish , King Vanessa M. , Pillai Avinesh , Romero-Ferrando Beatriz , Brinkhuis Martijn , Copeland Bronwyn M. , Samad Shah , Liao Shenyang , Schepel Jan A. C. 
Published: February 2021

Abstract
Background
Brain energy metabolism is impaired in Alzheimer’s disease (AD), which may be mitigated by a ketogenic diet. We conducted a randomized crossover trial to determine whether a 12-week modified ketogenic diet improved cognition, daily function, or quality of life in a hospital clinic of AD patients.

Methods
We randomly assigned patients with clinically confirmed diagnoses of AD to a modified ketogenic diet or usual diet supplemented with low-fat healthy-eating guidelines and enrolled them in a single-phase, assessor-blinded, two-period crossover trial (two 12-week treatment periods, separated by a 10-week washout period). Primary outcomes were mean within-individual changes in the Addenbrookes Cognitive Examination - III (ACE-III) scale, AD Cooperative Study - Activities of Daily Living (ADCS-ADL) inventory, and Quality of Life in AD (QOL-AD) questionnaire over 12 weeks. Secondary outcomes considered changes in cardiovascular risk factors and adverse effects.

Results
We randomized 26 patients, of whom 21 (81%) completed the ketogenic diet; only one withdrawal was attributed to the ketogenic diet. While on the ketogenic diet, patients achieved sustained physiological ketosis (12-week mean beta-hydroxybutyrate level: 0.95 ± 0.34 mmol/L). Compared with usual diet, patients on the ketogenic diet increased their mean within-individual ADCS-ADL (+ 3.13 ± 5.01 points, P = 0.0067) and QOL-AD (+ 3.37 ± 6.86 points, P = 0.023) scores; the ACE-III also increased, but not significantly (+ 2.12 ± 8.70 points, P = 0.24). Changes in cardiovascular risk factors were mostly favourable, and adverse effects were mild.

Conclusions
This is the first randomized trial to investigate the impact of a ketogenic diet in patients with uniform diagnoses of AD. High rates of retention, adherence, and safety appear to be achievable in applying a 12-week modified ketogenic diet to AD patients. Compared with a usual diet supplemented with low-fat healthy-eating guidelines, patients on the ketogenic diet improved in daily function and quality of life, two factors of great importance to people living with dementia.

Trial registration
This trial is registered on the Australia New Zealand Clinical Trials Registry, number ACTRN12618001450202. The trial was registered on August 28, 2018.
Arthritis as an initial presentation of malignancy: two case reports
Authors: Sachdev Manjit Singh Benjamin , Wan Sharifah Aishah , Cheong Yaw Kiet , Chuah Seow Lin , Teh Cheng Lay , Jobli Ahmad Tirmizi 
Published: February 2021

Abstract
Background
Arthritis is rarely reported as a paraneoplastic manifestation of occult malignancy. We report herein two cases of paraneoplastic arthritis due to occult malignancy.

Case 1
The patient was a 65-year-old woman of asian descent who was a former smoker with a history of spine surgery performed for L4/L5 degenerative disc disease. She presented with a 1-month history of oligoarthritis affecting both ankle joints and early morning stiffness of about 3 hours. Laboratory tests were positive for antinuclear antibody at a titer of 1:320 (speckled) but negative for rheumatoid factor. She was treated for seronegative spondyloarthritis and started on prednisolone without much improvement. A routine chest radiograph incidentally revealed a right lung mass which was found to be adenocarcinoma of the lung. She was treated with gefitinib and her arthritis resolved.

Case 2
The patient was a 64-year-old woman of asian descent, nonsmoker, who presented with a chief complaint of asymmetrical polyarthritis involving her right wrist, second and third metacarpophalangeal joints, and first to fifth proximal interphalangeal joints. She was treated for seronegative rheumatoid arthritis (RA) and started on sulfasalazine, with poor clinical response. Six months later, she developed abdominal pain which was diagnosed as ovarian carcinoma by laparotomy. Her arthritis resolved following treatment of her malignancy with chemotherapy.

Conclusion
In summary, paraneoplastic arthritis usually presents in an atypical manner and responds poorly to disease-modifying antirheumatic drugs. Accordingly, we recommend screening for occult malignancy in patients presenting with atypical arthritis.
A risk-sensitive task offloading strategy for edge computing in industrial Internet of Things
Authors: Hao Xiaoyu , Zhao Ruohai , Yang Tao , Hu Yulin , Hu Bo , Qiu Yuhe 
Published: February 2021

AbstractEdge computing has become one of the key enablers for ultra-reliable and low-latency communications in the industrial Internet of Things in the fifth generation communication systems and is also a promising technology in the future sixth generation communication systems. In this work, we consider the application of edge computing to smart factories for mission critical task offloading through wireless links. In such scenarios, although high end-to-end delays from the generation to completion of tasks happen with low probability, they may incur severe casualties and property loss and should be seriously treated. Inspired by the risk management theory widely used in finance, we adopt the Conditional Value at Risk to capture the tail of the delay distribution. An upper bound of the Conditional Value at Risk is derived through analysis of the queues both at the devices and the edge computing servers. We aim to find out the optimal offloading policy taking into consideration both the average and the worst-case delay performance of the system. Given that the formulated optimization problem is a non-convex mixed integer nonlinear programming problem, a decomposition into subproblems is performed and a two-stage heuristic algorithm is proposed. The simulation results validate our analysis and indicate that the proposed algorithm can reduce the risk in both the queueing and end-to-end delay.
Effect of the Curing Condition and High-Temperature Exposure on Ground-Granulated Blast-Furnace Slag Cement Concrete
Authors: Shumuye Eskinder Desta , Zhao Jun , Wang Zike 
Published: February 2021

AbstractIn this study, the effect of curing temperature on the properties of slag cement concrete after high-temperature exposure was studied, and elevated curing temperature (45 ± 2 °C and 95% relative humidity (RH)) was selected to compare with the standard curing temperature (20 ± 2 °C and 95%RH). Four different concrete mixes with the same mix proportion, except for different slag replacement ratios, were used: 0% (reference), 30% (slag), 50% (slag), and 70% (slag). After high-temperature exposure at 200, 400, 600, and 800 °C, the effect of slag replacement, high temperature, and curing temperature on the compressive strength and mineralogical and microstructural properties of slag cement concrete were studied. Test results indicated that the compressive strength of concrete cured for 7 d at elevated temperatures increased by 28.2, 20.7, 28.8, and 14.7% compared with that cured at the standard curing condition at slag percentages of 0, 70, 50, and 30%, respectively. X-ray diffraction (XRD) and Scanning electron microscope (SEM) results revealed that concrete cured at elevated temperatures exhibited a more condensed phase and contained a higher percentage of hydrates than that cured for 7 d in the standard curing condition. However, after 56 d of curing, concrete in the standard curing condition exhibited a more stable phase and a higher concentration of hydrates.
Class center-based firefly algorithm for handling missing data
Authors: Nugroho Heru , Utama Nugraha Priya , Surendro Kridanto 
Published: February 2021

AbstractA significant advancement that occurs during the data cleaning stage is estimating missing data. Studies have shown that improper data handling leads to inaccurate analysis. Furthermore, most studies indicate the occurrence of missing data irrespective of the correlation between attributes. However, an adaptive search procedure helps to determine the estimates of the missing data when correlations between attributes are considered in the process. Firefly Algorithm (FA) implements an adaptive search procedure in the imputation of the missing data by determining the estimated value closest to others' value. Therefore, this study proposes a class center-based adaptive approach model for retrieving missing data by considering the attribute correlation in the imputation process (C3-FA). The result showed that the class center-based firefly algorithm (FA) is an efficient technique for obtaining the actual value in handling missing data with the Pearson correlation coefficient (r) and root mean squared error (RMSE) close to 1 and 0, respectively. In addition, the proposed method has the ability to maintain the true distribution of data values. This is indicated by the Kolmogorov–Smirnov test, which stated that the value of DKS for most attributes in the dataset is generally closer to 0. Furthermore, the accuracy evaluation results using three classifiers showed that the proposed method produces good accuracy.
Intercontinental Multidisciplinary Oncology Videoconferencing for Rare and Complex Cancer: An Alternative to Systematic Transfer
Authors: Honoré Charles , Mir Olivier , Geraud Arthur , Drovetti Gianmaria , Garcia Gabriel C. T. E. , Gustin Pierre , Colomba Emeline , Pilorge Sylvain , Matias Margarida , Majer Michael , Balleyguier Corinne , Azoulay Mikael , Besse Benjamin , Herve Robert , Vial Gregory , Ducreux Michel 
Published: February 2021

PURPOSE: To report our experience of intercontinental multidisciplinary oncology videoconferencing between the French mainland and South Pacific to discuss rare and/or complex cancer cases. METHODS: On the first and third Friday of each month, all participants connected between 6:30 am and 8:00 am GMT to discuss using a web conference service. RESULTS: Between November 2019 and April 2020, 99 cases concerning 78 patients were discussed. Oncology subspecialties required were sarcoma (n = 36), digestive (n = 29), dermatology (n = 5), gynecology (n = 5), breast (n = 5), urology (n = 5), hematology (n = 5), ENT (n = 3), thoracic (n = 3), thyroid (n = 2), and pediatric (n = 1). Median patient age was 58 years, 41 were female (53%), 37 were male (47%), and 43 had a metastatic disease (55%). Following discussion, 16 patients (21%) were transferred to the French mainland. Reasons for transfer were requirement for complex surgery (n = 11) and need for specialized diagnostic biopsy (n = 5). Fifty-six patients were treated locally, with systemic chemotherapy (n = 36), surveillance (n = 8), surgery (n = 8), radiotherapy (n = 3), or endoscopy (n = 1). Direct benefits for patients treated in their local facility included strategy changes (surveillance or surgery contraindication, n = 9), targeted therapy decision (n = 14), immunotherapy decision (n = 9), and diagnostic or metastatic status corrections (n = 4). Six patients are still awaiting decision. CONCLUSION: Using real-time intercontinental multidisciplinary oncology videoconferencing to discuss complex or rare cancer cases is reliable and effective for decision making. This concept helped to limit to 21% the need for transfers to the mainland.
Genetic and Metabolic Determinants of Plasma Levels of ANGPTL8
Authors: Oldoni Federico , Bass Kevin , Kozlitina Julia , Hudson Hannah , Shihanian Lisa M , Gusarova Viktoria , Cohen Jonathan C , Hobbs Helen H 
Published: February 2021

Abstract

Context
ANGPTL8 (A8) plays a key role in determining the tissue fate of circulating triglycerides (TGs). Plasma A8 levels are associated with several parameters of glucose and TG metabolism, but the causality of these relationships and the contribution of genetic variants to differences in A8 levels have not been explored.

Objective
To characterize the frequency distribution of plasma A8 levels in a diverse population using a newly-developed enzyme-linked immunosorbent assay (ELISA) and to identify genetic factors contributing to differences in plasma A8 levels.

Methods
We studied a population-based sample of Dallas County, comprising individuals in the Dallas Heart Study (DHS-1, n = 3538; DHS-2, n = 3283), including 2131 individuals with repeated measurements 7 to 9 years apart (age 18-85 years; &gt;55% female; 52% Black; 29% White; 17% Hispanic; and 2% other). The main outcome measures were associations of A8 levels with body mass index (BMI), plasma levels of glucose, insulin, lipids, and hepatic TGs, as well as DNA variants identified by exome-wide sequencing.

Results
A8 levels varied over a 150-fold range (2.1-318 ng/mL; median, 13.3 ng/mL) and differed between racial/ethnic groups (Blacks &gt; Hispanics &gt; Whites). A8 levels correlated with BMI, fasting glucose, insulin, and TG levels. A variant in A8, R59W, accounted for 17% of the interindividual variation in A8 levels but was not associated with the metabolic parameters correlated with plasma A8 concentrations.

Conclusions
A8 levels were strongly associated with indices of glucose and TG metabolism, but the lack of association of genetic variants at the A8 locus that impact A8 levels with these parameters indicates that differences in A8 levels are not causally related to the associated metabolic phenotypes.
Highly polarization-sensitive, broadband, low dark current, high responsivity graphene-based photodetector utilizing a metal nano-grating at telecommunication wavelengths
Authors: Khosravian Elham , Mashayekhi Hamid Reza , Farmani Ali 
Published: February 2021

Recent advances in graphene-based photodetectors have demonstrated the feasibility of utilizing graphene as a fantastic material for the development of future high-performance photodetectors. In this paper, a high-performance graphene-based photodetector is proposed with plasmonic structure by employing a single graphene layer, periodic metal nano-grating, and

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substrate. The plasmonic coupling phenomena between graphene and the metal nano-grating can cause absorption enhancement in this structure. The proposed structure has almost perfect absorption at the telecommunication wavelength (1.55 µm), and its optical response shows a polarization-sensitive characteristic in the spectral range from 1 µm to 2.1 µm. Moreover, the electrical characterization and the dynamic response of this structure are obtained. Based on simulation results, the proposed structure under 0.5 mW incident optical power and at a wavelength of 1.55 µm exhibits a low dark current on the order of about 0.001 mA, maximum photocurrent of 0.81 mA, and responsivity of 1650 mA/W at a bias voltage of 3 V. Also, the rise time of the dynamic response is determined to be about 87 ps, and the 3 dB bandwidth of the frequency response is obtained to be about 4 GHz.