bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of life patients treated with rituximab intravenous versus subcutaneous in B-cell lymphomas: results from outpatient Hematooncology Clinic in Lodz
Authors: Witkowska Magdalena , Witkowska Sonia , Klimczak Marika , Frydecka Anna , Witkowski Michał , Smolewski Piotr 
Published: August 2021

Introduction: Nowadays, rituximab is available both as intravenous (IV) and subcutaneous (SC) formulations. The aim of this study is to compare quality of life (QOL) of patients treated in Hematooncology Clinic in Lodz with B-cell nonHodgkin lymphoma (B-NHL) treated with rituximab IV and SC.

Material and Methods: In 50 adult patients with B-NHL diagnosis we assessed QOL by three different questionnaries (EORTC QLQ-C30, FACT/ GOG-NTx and EQ-5D). We compared it between patients treated with rituximab IV and SC.

Results: In comparison of general condition in EQ-5D-3L and EORTC QLQ-C30 questionnaire patients treated with rituximab SC felt statistically better than with IV administration (p<0.01). In SC group general health was evaluated for 72 while in IV for only 58,1. According to FACT/GOG-NTx questionnaire SC group had significantly better physical well-being. In SC group we observed statistically more complete responses (CR) 21 (88%) versus 17 (65%) in IV group. Moreover, trend was observed in emotional well-being in favor of SC treatment.

Discussion: In our study we observed for the first time in the literature statistical difference in frequency of vomiting, nausea, and lack of appetite mentioned from our patients in questionnarie. It is very important that this findings were not published in any other study comparing SC and IV route od administration. Also looking at economic side of SC administration, this type of dosing. As a result it should be preferred form for B-cell lymphoma patients.
Antidiabetic drugs and the risk of cancer: beneficial, neutral, or detrimental?
Authors: Azeez Taoreed Adegoke , Folorunso Sharif Adeniyi , Eguzozie Chinedu , Adegboyega Adeleke Adedapo 
Published: August 2021

Abstract
The prevalence of diabetes mellitus is rapidly rising, especially in low- and middle-income countries. Also, early-onset diabetes is on the rise, and millions of individuals have to be on antidiabetic medications for a prolonged period. Therefore, more people are getting exposed to the adverse effects of antidiabetic medications.
Cancer is among the top ranking causes of death worldwide. Researches are still ongoing to understand the etiologies, precipitants, risk factors, correlates, and predictors of cancers. Diabetes mellitus is associated with various cancers, as extensively documented in the literature. There are conflicting reports about the association between antidiabetic drugs and cancer. This is even of crucial importance, considering that the prevalence of diabetes is rising.
Insulin glargine is reported to be associated with cancers, but clinical trials have not confirmed this. Metformin is largely believed to be beneficial in oncologic practice. Glibenclamide is reported to reduce tumor growth. The association between pioglitazone and bladder cancer is still an area for further research. Meglitinides have also been associated with cancers. Incretin-based therapy and the α-glucosidase inhibitors appear to have beneficial effects on cancers.
There is still a need for randomized multicentric clinical trials to further substantiate and clarify reports from epidemiological studies. Further in vitro studies will also be necessary to characterize the interaction of these pharmacological agents with other molecules in the body.
Impact of vitamin D serum levels on clinicopathological features and outcome in advanced pancreatic carcinoma
Authors: Mohammed Amrallah A. , Salem Reham A. 
Published: August 2021

Abstract

Background
Growing evidence encourages the preventive role of vitamin D in pancreatic carcinoma (PC). Meanwhile, the prognostic or predictive role needs more investigations. This study aimed to evaluate the correlation between serum vitamin D levels and the clinicopathological features with the outcome in advanced pancreatic carcinoma (APC).

Materials and methods
The current prospective study included 176 patients with APC. Assessing 25-hydroxy vitamin D is the most accurate method to measure the serum vitamin D levels. Serum vitamin D levels <20 ng/ml are defined as vitamin D deficiency, while levels ranging from 20 to 29 ng/ml are defined as vitamin D insufficiency. Before any treatment modalities were administered, the serum vitamin D levels were measured by enzyme-linked immunosorbent assay (ELISA).

Results
Serum vitamin D insufficiency and deficiency were detected in 28.4% and 31.8%, respectively. A large tumor size, higher grade, liver metastasis, higher serum level of CA 19-9, poor ECOG PS, and low overall response rate (ORR) were associated with lower serum vitamin D levels (p = 0.000). The median follow-up period was 7.6 months (range 0.6–18.6). The ORR was 23.2%, 54%, and 82.9% of vitamin D deficiency, insufficiency, and normal levels of vitamin D, respectively. The median OS was 11.4 months for patients with normal serum vitamin D levels, compared with 2.7 and 7.03 months for serum vitamin D deficiency and insufficiency, respectively.

Conclusions
Among patients with APC, serum vitamin D levels are considered a promising prognostic factor. It is associated with various poor prognostic features and worse survival outcome.
The Main Problems of Podcasting in Russia
Authors: Kruglova L. A. , Mamedov D. Z. 
Published: August 2021

Purpose. The article presents the results of the analysis of the podcasting market in Russia. It highlights the main problems of the industry, the types of podcast producers, and their monetization models developed in the Russian market. The revenues and expenses of podcast studios are also in focus of study.Results. The research is based on the study of the platforms themselves, scientific papers in the field of podcasting, Internet resources, company reporting, and expert interviews conducted by the authors. The authors have carried out the study in the autumn-winter of 2020.Conclusion. The authors identify five main industry monetization models (which can be combined): advertising, podcasts for companies, podcasts for streaming platforms, donations, and subscriptions. The authors come to the conclusion that despite the main modern problems of Russian podcasting – the absence of regular audience measurements, a single platform, and, as a result, difficulties with monetization – the conditions for launching a podcast studio in the Russian market are favorable.
Strengths of Struts and Nodal Zones for Strut-and-Tie Model Design of Reinforced Concrete Corbels
Authors: Yun Young Mook , Lee Youjong 
Published: August 2021

The strut-and-tie model (STM) method is useful for the limit state design of reinforced concrete (RC) corbels. However, for the rational design of RC corbels, designers must accurately determine the strengths of concrete struts and nodal zones to check the strength conditions of a selected STM and the anchorage of reinforcing bars in nodal zones. In this study, the authors suggested a numerical process for determining the strengths of concrete struts and nodal zones in RC corbel STMs. The technique incorporates the state of two-dimensional (2-D) stresses at the strut and nodal zone locations, 2-D failure envelope of concrete, deviation angle between the strut orientation and compressive principal stress trajectory, and the effect of concrete confinement by reinforcing bars. The authors also proposed the strength equations of struts and nodal zones that apply to the typical determinate and indeterminate STMs of RC corbels. The authors considered the effects of the shear span-to-effective depth ratio, the horizontal-to-vertical load ratio, and the primary tensile and horizontal shear reinforcement ratios in developing the strength equations. The authors predicted the failure strengths of 391 RC corbels tested to examine the appropriateness of the proposed numerical process and strength equations. The predicted failure strength compares very well with experimental results, proving that the rational analysis and design of RC corbels are possible by using the present study's strut and nodal zone strengths. Doi: 10.28991/cej-2021-03091725 Full Text: PDF
Prediction of Rutting in Flexible Pavements using Finite Element Method
Authors: Asim Muhammad , Ahmad Mahmood , Alam Muhammad , Ullah Shahid , Iqbal Muhammad Junaid , Ali Shahid 
Published: August 2021

In this research study three dimensional (3D) finite element analysis are performed on a flexible pavement section for different material properties, temperature and loading conditions. The main objective of this study is to predict the rut depth under different conditions of temperature, loadings and material properties. Three dimensional finite element model of flexible pavement is developed using ABAQUS to predict rut depth. The pavement system is assumed to be an elastic multi-layers system with each layer being isotropic, homogeneous with specified Resilient Modulus (Mr) and Poisson ratio (µ). With the exception of the bottom subgrade layer, each layer is extending to an unlimited horizontal extent and has a finite thickness. The pavement system analyze in this study for a cyclic load of 10000 cycles taken as 0.01sec per cycle. Standard Axle Load (ESAL) of 18 kips (80 kN) loading on an axle with a dual set of tires, the wheel spacing is 13.78 in (350 mm) with a tire contact pressure of 100 psi (0.69 MPa) is used. After performing a series of analysis the results showed that rut depth increases with increase in temperature and loading and decreases by using base stabilizer. Doi: 10.28991/cej-2021-03091727 Full Text: PDF
Study on the Swelling Behavior of Clayey Soil Blended with Geocell and Jute Fibre
Authors: Kumar Sanjeev , Sahu Anil Kumar , Naval Sanjeev 
Published: August 2021

Expansive soils like clays undergo swelling that can both be detrimental and acceptable in different applications. In the Northern part of India, especially Delhi region, natural soils containing clays & clayey sands support most of the buildings. Mechanically stabilized clays mixed with sand are used for local earthwork construction such as roads and landfills. Exact understanding of the swelling behaviour of such soils is a pre-requisite before the start of any construction projects. In this paper the swelling behaviour of clayey soil reinforced with geocell & Jute fibres has been presented. The laboratory investigations include one dimensional swelling tests using California Bearing Ratio (CBR) mould to study the swelling properties for different mix proportions. The maximum decrease in swelling potential of Geocell reinforced specimens was observed at fibre content of 0.80 percent and 40mm fibre length, beyond which increase in the swelling potential and swelling pressure has been observed. With this optimal reinforcement, a reduction of 71.24 percent in swelling and 41.10 percent in swelling pressure has been observed as compared to unreinforced soils. The study provides a solution towards the treatment of expansive soils before starting any construction activity over such soils and a step towards mitigating disasters related to infrastructure facilities grounded on expansive soils. Doi: 10.28991/cej-2021-03091728 Full Text: PDF
The Early Age Strength Improvement of the High Volume Fly Ash Mortar
Authors: Bazzar Kaoutar , Hafiane Fatima Zahra , Alaoui Adil Hafidi 
Published: August 2021

In the last decade, the use of Fly ash as replacement to improve the strength and performance of the cement has become a part of mortar and concrete manufacturing. When the used amount of fly ash ranges from 20 to 25%, the proprieties of concrete and mortars such as strength and durability are improved, which also reduce the Portland cement consumption and its impact on environment. For some special applications the High-Volume Fly Ash (HVFA) (up to 50%) is recommended, but the use of HVFA is still limited because of the low early age strength. The aim of this study is to overcome the constraints caused by the use of the High-Volume Fly Ash, by upgrading the mortar using grinding to reduce the particle size, and by the application of an upsetting force to modify the behavior of swelling and to modify the crystal structure of ettringite in order to increase the early age strength of the mortar. The results show an increase in the rupture resistance at 7 days and 28 days by 60% and 30% respectively. Which will make the use of HVFA mortar possible in construction industry and therefore reduce more CO2 emissions from the cement production. Doi: 10.28991/cej-2021-03091731 Full Text: PDF
Effect of Blast Loading on Seismically Detailed RC Columns and Buildings
Authors: Fouad Marco , Fayed Mohamed N. , Hamdy Gehan A. , Abdelrahman Amr 
Published: August 2021

Explosions caused by standoff charges near buildings have drastic effects on the internal and external structural elements which can cause loss of life and fatal injuries in case of failure or collapse of the structural element. Providing structural elements with blast resistance is therefore gaining increasing importance. This paper presents numerical investigation of RC columns with different reinforcement detailing subjected to near-field explosions. Detailed finite element models are made using LS-DYNA software package for several columns having seismic and conventional reinforcement detailing which were previously tested under blast loads. The numerical results show agreement with the published experimental results regarding displacements and damage pattern. Seismic detailing of columns enhances the failure shape of the column and decrease the displacement values compared to columns with conventional reinforcement detailing. Further, the effect of several modeling parameters are studied such as mesh sensitivity analysis, inclusion of air medium and erosion values on the displacements and damage pattern. The results show that decreasing the mesh size, increasing erosion value and inclusion of air region provide results that are very close to experimental results. Additionally, application is made on a slab-column multistory building provided with protective walls having different connection details subjected to blast loads. The results of this study are presented and discussed. Use of a top and bottom floor slab connection of protective RC walls are better than using the full connection at the four sides to the adjacent columns and slabs. This leads to minimizing the distortion and failure of column, and therefore it increases the chance of saving the building from collapse and saving human lives. Doi: 10.28991/cej-2021-03091733 Full Text: PDF
Keanekaragaman jenis ikan di sungai Lempake Tepian kecamatan Sungai Pinang kota Samarinda
Authors: Purwati Sri , Masitah Masitah , Budiarti Sinta , Aprilia Yeni 
Published: August 2021

Penelitian ini bertujuan untuk mengetahui keanekaragaman jenis ikan di Sungai Lempake Tepian kecamatan Sungai pinang Kota Samarinda. Ikan-ikan di Sungai ini digunakan dikonsumsi oleh masyarakat. Perubahan kualitas air sungai menyebabkan adanya penurunan tingkat populasi dan spesies ikan di sungai tersebut. Pengambilan sampel secara purposive sampling yang dibagi menjadi 3 lokasi yakni sungai bagian hulu, tengah dan hilir. Berdasarkan analisis data indeks keanekarangan (H) 1.969 dikategorikan sedang, kemelimpahan relatif ikan seluang (29.8%), ikan sapu-sapu 27.35%, puyau (19.33%), ikan puyau (19.33%), ikan sepat (16.50%) dan ikan nila (7.07%). Indeks keseragaman (e) sebesar 0.394 dikategorikan sedang dan indeks Dominansi (C) jenis ikan di Sungai Lempake Tepian Kota Samarinda sebesar 0.04 maka dapat disimpulkan tidak ada spesies yang mendominasi di Sungai Lempake Tepian Kota Samarinda.
PENGARUH SENAM KAKI DIABETIK TERHADAP SENSITIVITAS KAKI PADA PENDERITA DIABETES MELITUS DI PUSKESMAS SUDIANG KECAMATAN BIRINGKANAYA KOTA MAKASSAR
Authors: Jaya Ningsih , Heriansyah Heriansyah , Dalle Ambo , Nasrullah Nasrullah , Nurhasanah Nurhasanah 
Published: August 2021

Diabetes Mellitus is a chronic condition that is marked by an increase in blood glucose concentration with the appearance of typical main symptoms, namely urine that taste sweet in large numbers. One of the most common complications of diabetes mellitus is the diabetic foot, which has signs and symptoms such as injury, infection and gangrene. Handling efforts in diabetes mellitus patients as well as prevention of complications is the regularity of diabetes patients perform physical activities. One of the physical activities recommended regularly is foot gymnastic movement. Gymnastics itself is expected to reduce the incidence of complications that occur in the feet of people with diabetes mellitus such as wounds. The purpose of this study to determine the effect of foot gymnastics on foot sensitivity in people with diabetes melitus at the sub-district health center sudiang biringkanaya city of Makassar. This research uses quasi experimental design with one group pretest - posttest design. The sampling technique was done by purposive sampling with 22 respondents. This study uses Wilcoxon test with significance level (<α = 0,05). From the results of statistical tests can be concluded that there is influence of foot gym on foot sensitivity in patients with diabetes mellitus with p value = 0.000.Keywords: Diabetic foot gymnastics, foot sensitivity.
UJI APLIKATIF MODUL PERAWATAN PASIEN PASCA STROKE DI RUMAH PADA WILAYAH KERJA PUSKESMAS BATUA KOTA MAKASSAR DAN PUSKESMAS BAJENG KABUPATEN GOWA
Authors: Bakri Asrijal 
Published: August 2021

AbstrakKeluarga perlu diberikan informasi tepat cara perawatan pasien pasca stroke di rumah. Informasi tepat tentunya meningkatkan pemahaman dan kemampuan keluarga. Hasil penelitian menunjukkan ada pengaruh pemberian discharge planning terhadap kemampuan keluarga dalam perawatan pasca stroke di rumah. Tujuan penelitian ini adalah dihasilkannya produk Modul Perawatan Pasien Pasca Stroke yang dapat dipahami dan diterapkan dengan mudah oleh anggota keluarga pemberi perawatan pasien pasca stroke (caregiver) di rumah. Jenis penelitian yaitu penelitian tindakan (action research) dengan model Ebbut yang terdiri dari tiga tahap, yaitu tahap kesatu dilakukan pengembangan ide dengan memonitoring kemampuan partisipan penelitian, Pada tahap kedua dilakukan revisi instrumen dan pelaksanaan serta monitoring kembali. Pada tahap ketiga dilakukan sama seperti tahap sebelumnya dan merumuskan pemecahan masalah yang didapatkan dari hasil penelitian ini. Tahapan penelitian akan dilakukan dengan focus group discussion (FGD). Hasil penelitian digambarakan pada setiap FGD, yaitu pada FGD kesatu ini didapatkan hasil bahwa Ke-17 responden meminta agar modul diperbaiki terutama dari gambar dan penjelasannya. Hasil FGD kedua adalah bahwa semua caregiver sepakat bahwa gambar dan narasi modul sudah sangat bagus. Setelah tim peneliti menjelaskan ulang modul, lalu dilatihkan kembali dengan 2 orang coba, yaitu salah satu petugas puskesmas pembantu serta 1 orang pasien yang dikunjungi ke rumahnya. Semua caregiver mulai memahami modul dan mampu menerapkannya dengan baik meskipun masih memerlukan bantuan dan pendampingan. Sedangkan hasil FGD ketiga adalah Setiap caregiver mampu melatihkan kegiatan yang telah diajarkan kepada para keluarga mereka sendiri. Membutuhkan pengulangan latihan sebanyak 2 kali sampai mereka mahir, para caregiver meminta tim peneliti untuk melakukan pendampingan beberapa kali sampai mereka dianggap mahir dan mampu melaksanakan kegiatan tersebut secara mandiri. Para caregiver setuju dengan model dan ukuran modul, karena mudah dibaca dengan huruf yang besar dan gambar lebih jelas. Berdasarkan hasil wawancara dan analisis peneliti maka dapat disimpulkan bahwa para caregiver merasa mendapatakan pengetahuan baru yang lebih komplit, karena selama ini hanya sebatas melihat dan mendengar perawatan pasien stroke oleh keluarga. Selain itu modul yang dihasilkan dapat dipahami dan dipraktikkan dengan mudah.
PENGARUH METODE ROLE ROLE PLAY TERHADAP PENINGKATAN KETERAMPILAN DALAM MENOLONG KORBAN TENGGELAM PADA MASYARAKAT PESISIR DI DESA TAMASAJU KABUPATEN TAKALAR
Authors: Hady Abd. , Simunati Hj. Simunati , Dillah Hj. Ramlah , Hariani Hariani , Yakub Alfi Syahar 
Published: August 2021

Penelitian ini bertujuan untuk mengetahui pengaruh metode Role Play terhadap pengetahuan dan keterampilan masyarakat pesisisr dalam menolong korban tenggelam di Desa Tamasaju dengan metode pendekatan quasi experimental dengan rancangan one group pretest-postest design. Hasilnya menunjukkan bahwa seluruh responden mengalami peningkatan pengetahuan setelah dilakukan role play dalam menolong korban tenggelam dengan (p=0,000) dan total skor keterampilan yang meliputi keterampilan bantuan hidup dasar, balut bidai, menghentikan perdarahan dan manajemen airway sebelum metode Role Play, 38,66 mengalami peningkatan menjadi 90,54 setelah metode Role Play. Hasil uji statistic didapatkan nilai p=0,000 maka dapat disimpulkan bahwa terjadi peningkatan pengetahuan dan keterampilan dalam menolong korban tenggelam setelah diberikan role play.
Knowledge, Attitude, and Practice toward COVID-19 Questionnaire-Indonesian Version
Authors: Rosyad Yafi Sabila , Rias Yohanes Andy , Sitohang Tiur Romatua , Vianitati Pasionista , Fembi Pembronia Nona , Surahmat Raden , Desriva Nia 
Published: August 2021

Coronavirus disease was detected for the first time since the extraordinary incident in Wuhan, China, in December 2019 and has now spread to 204 countries. COVID-19 is a highly contagious disease. This study aimed to translate the Knowledge, Attitude, and Practice toward COVID-19 Questionnaire and evaluate its validity and reliability Indonesia version. The original was Knowledge, Attitude, and Practice toward COVID-19 Questionnaire translated from English into Indonesian. The reliability scale analysis technique does validity and reliability testing. The question item validity is sawed from the magnitude of r-table value with r-count and reliability seen through Cronbach's alpha coefficiency. This study shows the Knowledge, Attitude, and Practice toward COVID-19 Questionnaire in the context of Indonesian all items of valid and reliable.