bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antioxidant, Anti-Inflammatory and Cytotoxic Activities of Jasminum multiflorum (Burm. F.) Andrews Leaves towards MCF-7 Breast Cancer and HCT 116 Colorectal Cell Lines and Identification of Bioactive Metabolites
Authors: El-Hawary Seham S. , EL-Hefnawy Hala M. , Osman Samir M. , El-Raey Mohamed A. , Mokhtar Fatma A. , Ibrahim Haitham A. 
Published: September 2021

Background:
The plants of high phenolic contents are perfect antioxidant and anti-inflammatory agents and
participate in biological studies as effective agents towards different cancer cell lines.

Objective:
To investigate the antioxidant, anti-inflammatory, and cytotoxic activities of the hydromethanolic leaf extract
of Jasminum multiflorum (Burm. f.) Andrews. (J. multiflorum), and phenolic profiling of the extract.

Methods:
The antioxidant activity for the extract was estimated using β-Carotene-linoleic and Ferric Reducing Antioxidant
Power (FRAP) assays. The anti-inflammatory activity was evaluated by histamine release assay. Cytotoxicity of
J. multiflorum was performed using a neutral red uptake assay towards breast cancer (MCF-7) and colorectal cancer
(HCT 116) cell lines. Phenolic profiling of the leaves was characterized using high performance liquid chromatography
coupled to photodiode array detector-mass spectroscopy-mass spectroscopy (HPLC-PDA-MS/MS), and chromatographic
isolation and identification of the isolated compounds were performed using spectroscopic and NMR data, and
virtual docking was performed to the isolated compounds against HSP90 (HEAT SHOCK PROTEIN 90).

Results :
At a concentration of 75 μg mL-1, J. multiflorum extract showed high antioxidant power; 68.23±0.35 % inhibition
and 60.30±0.60 a TEAC (μmol Trolox g-1) for β-Carotene-linoleic assay and FRAP assay; respectively, and
possessed anti-inflammatory activity with IC50 67.2 μg/ml. J. multiflorum showed high cytotoxic activity with IC50 of
24.81 μg/ml and 11.38 μg/ml for MCF-7 and HCT 116 cell lines, respectively. HPLC-PDA-MS/MS analysis tentatively
identified 39 compounds; major compounds are secoiridoid glycosides, kaempferol, and quercetin glycosides, in
addition to simple phenylethanoid compounds. Isolation of active metabolites was performed and led to the isolation
and identification of four compounds. On the basis of docking study using HSP90 legend, kaempferol neohesperidoside
showed a high cytotoxic potential supported by a high affinity score towards HSP90 legend protein.

Conclusion:
Jasminum multiflorum is a good candidate to isolate cytotoxic agents.
Cholesterol Decorated Pyridinium Urea and Carbamate as π-Gelators for
Selective Recognition of F- Ions
Authors: Panja Santanu , Ghosh Kumaresh 
Published: September 2021

Aim:
The design and synthesis of new molecules capable of forming self-assembled gels
are indispensable to harvest new functional materials. Supramolecular gels have potential in many areas,
particularly in biology and materials chemistry. Of the different types of applications, visual sensing
of biologically relevant ionic analytes is a fairly recent trend. Here we describe naked-eye detection
of fluoride ions involving sol-gel methodology.

Methods:
To execute this, cholesterol substituted pyridinium salts 1-4 have been designed and synthesized,
of which compounds 3 and 4 served as potential gelators for the naked-eye detection of F- ions
in DMSO and DMSO-H2O (1:1, v/v), respectively.

Results:
Addition of F- ions to the solutions of 3 and 4 in DMSO and DMSO: H2O (1:1, v/v) respectively,
resulted in the formation of yellow and brown colored gels instantly at room temperature.

Conclusion:
Gelation study reveals that not only the aromatic surface is crucial for the selfaggregation
of molecules via π-π stacking interactions, but also polarity, rigidity, and conformational
flexibility of the molecules that govern the intermolecular association of gelators are important. Moreover,
the incorporation of fluorophore (naphthalene) as an aromatic surface in the molecular designs
enables the gelator molecules to execute the sensing of F- with a high degree of sensitivity in the solution
phase.
Machine Learning Analysis of Time-Dependent Features for Predicting Adverse Events During Hemodialysis Therapy: Model Development and Validation Study
Authors: Liu Yi-Shiuan , Yang Chih-Yu , Chiu Ping-Fang , Lin Hui-Chu , Lo Chung-Chuan , Lai Alan Szu-Han , Chang Chia-Chu , Lee Oscar Kuang-Sheng 
Published: September 2021

Background
Hemodialysis (HD) therapy is an indispensable tool used in critical care management. Patients undergoing HD are at risk for intradialytic adverse events, ranging from muscle cramps to cardiac arrest. So far, there is no effective HD device–integrated algorithm to assist medical staff in response to these adverse events a step earlier during HD.

Objective
We aimed to develop machine learning algorithms to predict intradialytic adverse events in an unbiased manner.

Methods
Three-month dialysis and physiological time-series data were collected from all patients who underwent maintenance HD therapy at a tertiary care referral center. Dialysis data were collected automatically by HD devices, and physiological data were recorded by medical staff. Intradialytic adverse events were documented by medical staff according to patient complaints. Features extracted from the time series data sets by linear and differential analyses were used for machine learning to predict adverse events during HD.

Results
Time series dialysis data were collected during the 4-hour HD session in 108 patients who underwent maintenance HD therapy. There were a total of 4221 HD sessions, 406 of which involved at least one intradialytic adverse event. Models were built by classification algorithms and evaluated by four-fold cross-validation. The developed algorithm predicted overall intradialytic adverse events, with an area under the curve (AUC) of 0.83, sensitivity of 0.53, and specificity of 0.96. The algorithm also predicted muscle cramps, with an AUC of 0.85, and blood pressure elevation, with an AUC of 0.93. In addition, the model built based on ultrafiltration-unrelated features predicted all types of adverse events, with an AUC of 0.81, indicating that ultrafiltration-unrelated factors also contribute to the onset of adverse events.

Conclusions
Our results demonstrated that algorithms combining linear and differential analyses with two-class classification machine learning can predict intradialytic adverse events in quasi-real time with high AUCs. Such a methodology implemented with local cloud computation and real-time optimization by personalized HD data could warn clinicians to take timely actions in advance.
Effectiveness of Secondary Metabolites from Entomopathogenic Fungi for Control Nilaparvata lugens Stål. in the Laboratory Scale
Authors: Minarni Endang Warih , Soesanto Loekas , Suyanto Agus , Rostaman Rostaman 
Published: September 2021

Nilaparvata lugens Stål. is an essential pest in rice plants. This pest attack can reduce crop yields and even crop failure. This research was conducted to obtain secondary metabolites that are effective in controlling brown planthopper (BPH). A randomized block design was used to test the effectiveness of secondary metabolites against BPH. The treatments tested were secondary metabolites produced by eight isolates of fungi consist of three concentrations: 5, 10, and 15%. Water and imidacloprid insecticide were used as control. The eight isolates were: J11 (Aspergillus sp.), J22 (Lecanicillium saksenae), J34 (Myrothecium sp.), J35 (Beauveria sp.), J41 (Fusarium sp.), J56 (Fusarium sp), J60 (Simplicillium sp.), and J65 (Curvularia sp.). Each treatment was repeated three times. The variables observed were mortality and time of death of BPH. Data were analyzed using the F test and followed by a DMRT if significant differences existed. The results showed that the secondary metabolites of the Lecanicillium saksenae, Myrothecium sp., and Simplicillium sp. fungi effectively controlled BPH pests by 80‒100% within 3.22‒5.47 days. The fungus L. saksenae, Myrothecium sp., and Simplicillium sp. contain insecticidal compounds, clogging the insect spiraculum, antifeedant, repellant, and antimicrobial.
Erratum to “Biology and the Statistic Demographic of Aphis glycines Matsumura (Hemiptera: Aphididae) on the Soybean with Plant Growth Promoting Rhizobacteria (PGPR) Treatment” [Jurnal Perlindungan Tanaman Indonesia, 24(1), 54‒60]
Authors: Indonesia Jurnal Perlindungan Tanaman 
Published: September 2021

This is a correction to: Biology and the Statistic Demographic of Aphis glycines Matsumura (Hemiptera: Aphididae) on the Soybean with Plant Growth Promoting Rhizobacteria (PGPR) Treatment. Jurnal Perlindungan Tanaman Indonesia, 24(1), 54‒60. https://doi.org/10.22146/jpti.49846 In Author’s affiliation, typed as:Hermanu Triwidodo1)*, Anggun Agustini1), & Listihani1)1)Department of Plant Protection, Faculty of Agriculture, IPB UniversityJln. Kamper, Kampus IPB Dramaga, Bogor, West Java 16680 IndonesiaTherefore, the Author’s affiliation was corrected to:Hermanu Triwidodo1)*, Anggun Agustini1), & Listihani2)1)Department of Plant Protection, Faculty of Agriculture, IPB UniversityJln. Kamper, Kampus IPB Dramaga, Bogor, West Java 16680 Indonesia2)Faculty of Agriculture and Business, University of Mahasaraswati DenpasarJln. Kamboja No.11 A, Dangin Puri Kangin, Denpasar Utara, Bali 80233 Indonesia The editorial staff apologizes for the inconvenience. The online version of the corrected manuscript has been published in the open journal system of the Jurnal Perlindungan Tanaman Indonesia.
Sexual Health Teaching in the Family Medicine Clerkship: Results of a CERA Survey
Authors: Stumbar Sarah E. , Garba Nana Aisha , de la Cruz Marisyl , Bhoite Prasad , Holley Matthew , Adams Christine , Virani Anna , Kale Neelima 
Published: September 2021

Introduction: With growing efforts to provide comprehensive and inclusive sexual health care, family medicine clerkships are well positioned to educate learners about a spectrum of related topics. This study investigated the current state of sexual health instruction in family medicine clerkships, including specific factors impacting its delivery.
Methods: Questions about sexual health curricula were created and included as part of the 2020 Council of Academic Family Medicine’s Educational Research Alliance survey of family medicine clerkship directors. The survey was distributed via email to 163 recipients between June 1, 2020 and June 25, 2020.
Results: One hundred five (64.42%) of 163 clerkship directors responded to the survey. Our results revealed that during family medicine clerkships, family planning, contraception, and pregnancy options counseling are covered significantly more often than topics related to sexual dysfunction and satisfaction and LGBTQ+ health. Most clerkship directors (91.5%) reported less than 5 hours of sexual health training in their curriculum. Those with more dedicated sexual health curricular hours were more likely to include simulation. Lack of time (41.7%) was the most frequently reported barrier to incorporating sexual health content into the clerkship.
Conclusions: Coverage of sexual health topics during the family medicine clerkship is limited in scope and delivery. To support curricular development and integration, future studies should more thoroughly examine the factors influencing the inclusion of sexual health content in family medicine clerkships as well as the development of assessment methods to determine competency.
Relationship Betweenparticipant’s Learning Readiness Educate Through Onlinewith the Learning Results on English Courses
Authors: Safitri Mahda , Setiawati Setiawati 
Published: September 2021

This research is based on the low learning outcomes of students online in English courses at the English Tutorial Center Padang, it is suspected that there is something to do with students' readiness to learn. The purpose of this study is to reveal: (1) a description of students' readiness to learn online, (2) student learning outcomes in English courses at the English Tutorial Center Padang, and (3) reveal the relationship between students' readiness to learn online and learning outcomes in the English course at the English Tutorial Center Padang. This type of research is descriptive correlational research through a quantitative approach. The population of this research is English course students for the period of July - August 2020, totaling 35 people and a sample of 70%, namely 24 people with cluster random sampling technique. The data collection technique used is a questionnaire and the tool used is a questionnaire. The data analysis technique used the percentage formula and the spearman rho formula.The results of this study indicate that: 1) students' online learning readiness in English courses at the English Tutorial Center Padang is low; 2) student learning outcomes in English courses at the English Tutorial Center Padang are low; 3) there is a significant relationship between students' readiness to learn online and their learning outcomes in English courses at the English Tutorial Center Padang. The suggestion of this research is that the manager of the English course at the English Tutorial Center Padang should provide facilities that will be used during learning so that it can foster enthusiasm and readiness to learn students. Instructors should be creative when using learning media so that they can bring up the enthusiasm and readiness of students to learn in the implementation of learning activities.Keywords: Learning Readiness,Learning Outcomes
The Relations of Tutor Teaching Performance and Science Learning Outcome of Learners at Paket B Equivalency Program
Authors: Mukhlis Sania Kasih , Irmawita Irmawita 
Published: September 2021

This research is motivated by the low learning outcomes of residents learning equivalence Package B at SPNF Pasaman Regency, this is thought to be due to the influence of tutor performance in learning of science subjects for class VIII. This study aims to: 1) describe the performance of tutors; 2) describe the learning outcomes of learning citizens; and 3) looking at the relationship between tutor performance in learning and learning outcomes in Science Class VIII Equivalence Package B at SPNF Pasaman Regency. This type of research is quantitative research with correlational descriptive technique. The population of this study were all students of class VIII Package B Program at SPNF Pasaman Regency, totaling 180 people and with a sample of 44 people. The data collection technique is in the form of a questionnaire with a data collection tool in the form of a questionnaire and the data is analyzed using the percentage technique and product moment correlation. The results showed that: (1) the performance of tutors in learning of science subjects for class VIII was categorized as low, (2) the learning outcomes of students were categorized as low, (3) there was a significant relationship between the performance of tutors in learning and science learning outcomes. class VIII Equality Package B at SPNF Pasaman Regency. It is recommended for institutions to pay more attention to the performance of tutors, and it is hoped that tutors can improve performance in learning.
The Relations Between Tutor Learning Strategy With Learning Performance in Equivalency Program Paket B
Authors: Husna Hayatul , Irmawita Irmawita 
Published: September 2021

This research is motivated by the low learning outcomes of social science subjects for equivalence education package B at PKBM Suka Maju Sejahtera, Padang City. This can be seen from the learning strategy provided by the tutor is not good so that it affects the learning outcomes of learning residents. The objectives of the research are: (1) to see the description of the tutor's learning strategy (2) to see the description of the learning outcomes obtained by the learning community; and (3) to find out the relationship between tutor learning strategies and learning outcomes for social studies subjects in equivalence education package B. This research is classified as quantitative with correlational type. The population in this study were 20 people, the sampling technique was in the form of random sampling and taken as much as 100% or all of those included in the population would be used as a sample of 20 people. The data collection technique uses a questionnaire with the tool in the form of a list of statements. The data were analyzed by the percentage formula and the data processing technique used the rank order formula. The results of this study are: (1) tutor learning strategies at PKBM Suka Maju Sejahtera Padang City are categorized as low. (2) the learning outcomes of social studies subjects are categorized as low. (3) there is a significant relationship between the tutor's learning strategy and the learning outcomes of social studies subjects for equivalence education package B at PKBM Suka Maju Sejahtera, Padang City. It is hoped that further researchers will be able to innovate by examining other variables.
Strategies Proposed for Listening Comprehension in PBT TOEFL: Tricks that Do Not Work
Authors: Mustafa Faisal , Putra Tomi Mandala 
Published: September 2021

Abstract: The Longman Preparation Course for the TOEFL, written by Phillips in 2003, is the most widely used coursebook for TOEFL test preparation. This book provides 17 strategies for Listening Comprehension Part A. Therefore, the current study examines whether the strategies provided in the book are applicable in a real test. The data were obtained from Part A of the TOEFL listening section in nine tests designed by Educational Testing Service (ETS). Each item in the test was tested against the proposed strategies. The results reveal that many items did not successfully match the strategies. Only two proposed strategies had matches of higher than 80%, while others were less than 10%. There are four strategies that did not have a match at all. All in all, very few strategies can be applied to answer the questions correctly without adequate comprehension. With comprehension, test takers can answer the questions without needing to rely on any of the proposed strategies. Therefore, the study concludes that most of the strategies proposed by Phillips (2003) are not successful in real test.Key words: strategies, PBT TOEFL, listening comprehension Abstrak: The Longman Preparation Course for the TOEFL yang ditulis oleh Phillips in 2003 paling banyak digunakan untuk pelatihan persiapan TOEFL. Buku tersebut berisi 17 strategi untuk menjawab soal TOEFP pada Part A. Oleh karena itu, penelitian ini menelaah apakah strategi dalam buku tersebut dapat digunakan untuk mengerjakan tes TOEFL yang sebenarnya. Data untuk penelitian ini diperoleh dari tes TOEFL bagian listening Part A yang diperoleh dari Educational Testing Service (ETS). Setiap soal pada tes tersebut dicocokkan dengan strategi yang terdapat dalam buku Phillips (2003). Hasil penelitian menunjukkan bahwa banyak soal tidak dapat dijawab dengan menggunakan strategi yang dianjurkan. Hanya ada dua strategi yang memiliki kecocokan lebih dari 80%, sedangkan yang lain kurang dari 10%. Ada dua strategi yang tidak cocok dengan satu soal manapun. Secara keseluruhan, sangat sedikit strategi yang dapat digunakan untuk menjawab soal TOEFL listening Part A tanpa pemahaman yang cukup. Dengan pemahaman, peserta tes bisa menjawab soal tanpa harus menggunakan strategi-strategi tersebut. Oleh karena itu, penelitian ini menyimpulkan bahwa kebanyakan strategi yang dikemukakan oleh Phillips (2003) tidak dapat digunakan untuk menjawab soal TOEFL asli.Kata kunci: strategi, PBT TOEFL, listening comprehension.
Foreign Figures in the Paintings of I Ketut Gede Singaraja
Authors: Dewa Gede Purwita 
Published: September 2021

I Ketut Gede Singaraja always portrays figures adopted from the depiction of wayang pattern. It is similar to Wayang Kamasan but more expressive. Aside of painting the local figures, he also painted foreign figures such as Javanese-Muslims, Chinese people, and Europeans. They were narrated as the cultural actors in the life of Singaraja City at the end of the 19th Century. This paper compares those figures, especially their attributes and faces thorugh iconographic studies. The result shows some cultural diversity through figures painted by I Ketut Gede Singaraja. The diversity is a plurality that occurred as a result of cultural unification from the previous period, namely the spice route period. The purpose of this paper is to identify the ethnic foreign figures described by I Ketut Gede Singaraja in his paintings as part of the multicultural life in Singaraja city at the end of the 19th century.
Histomorfometri Granulosit Bibit Sapi Bali di Nusa Penida
Authors: Mami Oktavyan Loys , Suwiti Ni Ketut , Setiasih Luh Eka 
Published: September 2021

Penelitian ini bertujuan untuk mengetahui histomorfometri granulosit bibit sapi bali di Nusa Penida. Sebanyak 50 ekor sapi bali betina diambil darahnya melalui vena jugularis menggunakan venoject. Selanjutnya dibuat apusan darah dengan metode slide, sampel difiksasi dan diwarnai dengan pewarnaan Giemsa. Histomorfometri granulosit yakni neutrofil,eosinofil,dan basofil diukur dengan menggunakan mikroskop Axio Imaginer Zeiss 2 dan software ZEN 2012. Data yang diperoleh dianalisis dengan descriptive statistics. Hasil penelitian menunjukan rerata diameter neutrofil yaitu 9,1±1,4?m dengan kisaran 6-11, eosinofil 8,9 ±1,6?m dengan kisaran 5-13 ?m, dan basofil 8,9 ±1,7?m dengan kisaran 5-11 ?m.
Modal Intelektual dan Pengungkapan Tanggung Jawab Sosial
Authors: Dewi Ni Putu Krisna , Ratnadi Ni Made Dwi 
Published: September 2021

Empirical testing of the correlation of intellectual capital and disclosure of social responsibility with, structural capital, customer capital, human capital is the purpose of this study. Companies that are included in the LQ45 list of the Indonesia Stock Exchange for the 2015-2017 period are used as samples in this study, and the purpose sampling method is used to collect samples. Multiple regression analysis technique is used through SPSS to analyze a data. Based on the previous study, it is concluded that human capital positively affects the disclosure of social responsibility, at the same time, neither structure_capital nor customer capital has any impact on the disclosure of social responsibility. The results of this study are in line with resource-based theory, legitimacy theory, and resource dependency theory. These theories believe that every company has different and unique resources, which can add a sustainable competitive advantage to the survival of the company, but companies as organizations rely on Strengths to provide resources and use them in their operations.
Keywords: Intellectual Capital; Disclosure of Social Responsibility.
Pendidikan dan Pelatihan Memoderasi Pengaruh Kemampuan Teknik Personal dan IT Sophistication pada Kinerja SIA
Authors: Utami I Gusti Agung Pradnya , Widhiyani Ni Luh Sari 
Published: September 2021

Implementation of AIS is indispensable for organizations as a means to support operational and administrative activities. This research aims to prove empirically the effect of ability personal techniques and IT sophistication with education and training as moderating variables on AIS performance. The population of this research is employees who use AIS at Dinas Perindustrian dan Perdagangan Provinsi Bali. The research sample was determined based on a non-probability sampling method with a saturated sample technique in order to obtain 84 civil servants who used AIS at Dinas Perindustrian dan Perdagangan Provinsi Bali. Data collection is done through questionnaire and interview. The analysis technique in this research is Moderated Regression Analysis (MRA). The result of analysis shows that education and training strengthen the effect of ability personal techniques and IT sophistication on AIS performance.
Keywords: Ability Personal Techniques; IT Sophistication; Education and Training; AIS Performance.