bluuebunny/crossref_metadata_2025_split huggingface dataset:
Haematological and biochemical abnormalities in hunting dogs infected with Acanthocheilonema reconditum, associated risk factors, and a European overview
Authors: Pacifico Laura , Ferrari Nicola , Romeo Claudia , Buono Francesco , Varuzza Paolo , Sgroi Giovanni , Neola Benedetto , Buch Jesse , Beall Melissa , Breitschwerdt Edward B. , Chandrashekar Ramaswamy , Veneziano Vincenzo , Piantedosi Diego 
Published: May 2021

AbstractAcanthocheilonema reconditum is a filarial parasite transmitted by arthropods (fleas, lice, and ticks) that infect dogs. There is minimal published data available to date on potential haematological and biochemical changes associated with this parasitic infection. Study aims were (i) provide an overview of A. reconditum in Europe, (ii) define A. reconditum prevalence and risk factors in a specific dog population (hunting) from southern Italy, and (iii) assess the frequency of haemato-biochemical abnormalities associated with infection. Blood samples collected from 3020 dogs were tested by a modified Knott’s technique to count and identify microfilariae. Eighty-four dogs were infected by A. reconditum (2.78%; 95% CI 2.19–3.37%). Microfilariae ranged from 1 to 212/ml. Based on clinical examination, all but six dogs with non-specific symptoms were healthy. Haematological abnormalities included leucocytosis (n = 15), with eosinophilia (n = 14) and monocytosis (n = 13). Serum biochemical abnormalities included increased total serum proteins (n = 19), albumins (n = 7), total globulins (n = 14), ALT (n = 1), and ALP (n = 1); one dog was hypoalbuminemic, and BUN was mildly increased in 2 dogs. Risk factors included the province origin (Napoli, OR=5.4, 95%CI: 2.1–14.0; Caserta, OR=5.1, 95%CI: 2.5–10.6), hunting wild mammals (OR=2.8, 95% 95%CI: 1.6–4.8), and ectoparasite infestation (OR=1.9, 95%CI: 1.1–3.1). There was a negative correlation between microfilaraemic load and decreased albumin level (−0.37; p=0.021). Our results showed that A. reconditum circulates within the hunting dog population of southern Italy, with seemingly low pathogenic potential.
Rapid molecular syndromic testing for aetiological diagnosis of gastrointestinal infections and targeted antimicrobial prescription: experience from a reference paediatric hospital in Spain
Authors: Castany-Feixas Marta , Simo Silvia , Garcia-Garcia Selene , Fernandez de Sevilla Mariona , Launes Cristian , Kalkgruber Marlene , Gene Amadeu , Muñoz-Almagro Carmen , Brotons Pedro 
Published: May 2021

AbstractAetiological diagnosis of gastrointestinal infections is challenging since a wide range of bacteria, parasites and viruses can be causal agents and derived clinical manifestations appear quite similar. Our aim was to evaluate contribution of the novel QIAstat-DxGastrointestinal Panel (GIP) to aetiological diagnosis of gastrointestinal infections and rational antimicrobial prescription in a reference paediatric hospital. Evaluation included comparison of diagnostic yield and agreement of results of QIAstat-Dx GIP and conventional microbiological methods. Parallel testing was performed on stool samples collected prospectively from children admitted to Sant Joan de Deu Barcelona Hospital (Spain) during the period February–March 2019. Influence of the panel test use on antimicrobial prescription was assessed using a pre–post study design. Eighty-six (68.8%) out of 125 specimens were positive by QIAstat-Dx GIP versus 44 (35.2%) positive by a composite of conventional methods (p<0.001). Global agreement of panel test results with rotavirus-adenovirus antigen detection (92.8%) and a two-step antigen/toxin and PCR-based algorithm for toxigenic Clostridioides difficile detection (87.5%) was greater than that with bacterial culture (76.0%) and parasite microscopic identification (64.3%). Panel test results orientated antimicrobial prescription changes in 18 (14.4%) patients, including antimicrobial start in 11 cases initially untreated, targeted antimicrobial prescription in 5 and discontinuation in 2 cases empirically treated. Results showed that QIAstat-Dx GIP significantly expanded aetiological diagnosis of gastrointestinal infections compared to conventional microbiological methods while orientating a more judicious use of antimicrobial drugs in hospitalised children.
Stand delineation based on laser scanning data and simulated annealing
Authors: Sun Yusen , Wang Weifang , Pukkala Timo , Jin Xingji 
Published: May 2021

AbstractThe use of airborne laser scanning (LS) is increasing in forestry. Scanning can be conducted from manned aircrafts or unmanned aerial vehicles (UAV). The scanning data are often used to calculate various attributes for small raster cells. These attributes can be used to segment the forest into homogeneous areas, called segments, micro-stands, or, like in this study, stands. Delineation of stands from raster data is equal to finding the most suitable stand number for each raster cell, which is a combinatorial optimization problem. This study tested the performance of the simulated annealing (SA) metaheuristic in the delineation of stands from grids of UAV-LS attributes. The objective function included three criteria: within-stand variation of the LS attributes, stand area, and stand shape. The purpose was to create delineations that consisted of homogeneous stands with a low number of small stands and a regular and roundish stand shape. The results showed that SA is capable of producing stand delineations that meet these criteria. However, the method tended to produce delineations where the stands often consisted of disconnected parts and the stand borders were jagged. These problems were mitigated by using a mode filter on the grid of stand numbers and giving unique numbers for all disconnected parts of a stand. Three LS attributes were used in the delineation. These attributes described the canopy height, the height of the bottom of the canopy and the variation of echo intensity within 1-m2 raster cells. Besides, a texture variable that described the spatial variation of canopy height in the proximity of a 1-m2 raster cell was found to be a useful variable. Stand delineations where the average stand area was about one hectare explained more than 80% of the variation in canopy height.
The Mw5.4 Zagreb (Croatia) earthquake of March 22, 2020: impacts and response
Authors: Atalić Josip , Uroš Mario , Šavor Novak Marta , Demšić Marija , Nastev Miroslav 
Published: May 2021

AbstractThis paper highlights the principal features of the Mw5.4 Zagreb earthquake. Located within the city limits at a depth of 10 km, the earthquake generated a peak ground acceleration of more than 0.2 g and a maximum spectral acceleration of about 0.6 g at 0.1 s in the historic downtown area. The situation was particularly challenging since the event occurred amid a partial Covid-19 lockdown at temperatures close to 0 °C, emphasizing the extensive and complex vulnerability of the local communities and individuals. 27 people were reported severely injured, one of which later died. The surprisingly high economic costs, needed to achieve a full reconstruction of damaged buildings and infrastructure in the affected area, are currently evaluated at more than 10B euros. Description of the organization of the emergency response in the first days and the observed damage to buildings is given with typical examples. The focus is on the performance of older masonry residential and cultural heritage buildings in the historic downtown, their inspection and evaluation of damage to structural and non-structural components. This information provides the basis for understanding of the negative impacts and clarifies the overall context identifying the enablers and barriers to the still ongoing recovery process. It also helps to increase the awareness of the seismic vulnerability of European cities with similar construction practices.
To What Extent Can Digitally-Mediated Team Communication in Children’s Physical Health and Mental Health Services Bring about Improved Outcomes? A Systematic Review
Authors: Jones Lauren Stephanie , Russell Ailsa , Collis Emma , Brosnan Mark 
Published: May 2021

AbstractDigital communication technologies can be used for team consultation, case management, and information sharing in health and mental health services for children and young people (CYP). The objective of the systematic review was to investigate the evidence as to whether digitally-mediated team communication for CYP improves outcomes. We searched PsycINFO, PubMed, Web of Science, and Cochrane Library for relevant studies. Results were synthesised narratively. Seven studies were identified from 439 initial records. Analysis highlighted that digitally-mediated team communication is generally valued by professionals for supporting practice and that there is overall satisfaction with the process. There was preliminary evidence (from one study) that clinical outcomes from digitally-mediated team communication are comparable to those achieved by a collaborative service model with direct specialist care to service users via digital communication technology. There is a need for further high-quality research into clinical outcomes and service user experience, as well as financial implications.
Cognitive and Electrophysiological Correlates of Working Memory Impairments in Neurofibromatosis Type 1
Authors: Pobric Gorana , Taylor Jason R. , Ramalingam Hemavathy M. , Pye Emily , Robinson Louise , Vassallo Grace , Jung JeYoung , Bhandary Misty , Szumanska-Ryt Karolina , Theodosiou Louise , Evans D. Gareth , Eelloo Judith , Burkitt-Wright Emma , Hulleman Johan , Green Jonathan , Garg Shruti 
Published: May 2021

AbstractNeurofibromatosis 1 (NF1) is a single gene disorder associated with working Memory (WM) impairments. The aim of this study was to investigate P300 event-related potential (ERP) associated with WM in NF1. Sixteen adolescents with NF1 were compared with controls on measures of WM and EEG was recorded during a WM nback task. The NF1 group showed poorer performance on measures of WM as compared to the control group. No group differences were observed in P300 amplitude at Pz, but P300 latency was shorter in the NF1 group. Topographic analyses of P300 amplitude showed group differences indicating neural processing differences in the NF1 group relative to controls, which possibly contribute to the cognitive deficits seen in this population.
Closed Structure
Authors: Fritz Peter , Lederman Harvey , Uzquiano Gabriel 
Published: May 2021

AbstractAccording to the structured theory of propositions, if two sentences express the same proposition, then they have the same syntactic structure, with corresponding syntactic constituents expressing the same entities. A number of philosophers have recently focused attention on a powerful argument against this theory, based on a result by Bertrand Russell, which shows that the theory of structured propositions is inconsistent in higher order-logic. This paper explores a response to this argument, which involves restricting the scope of the claim that propositions are structured, so that it does not hold for all propositions whatsoever, but only for those which are expressible using closed sentences of a given formal language. We call this restricted principle Closed Structure, and show that it is consistent in classical higher-order logic. As a schematic principle, the strength of Closed Structure is dependent on the chosen language. For its consistency to be philosophically significant, it also needs to be consistent in every extension of the language which the theorist of structured propositions is apt to accept. But, we go on to show, Closed Structure is in fact inconsistent in a very natural extension of the standard language of higher-order logic, which adds resources for plural talk of propositions. We conclude that this particular strategy of restricting the scope of the claim that propositions are structured is not a compelling response to the argument based on Russell’s result, though we note that for some applications, for instance to propositional attitudes, a restricted thesis in the vicinity may hold some promise.
Chameleonic knowledge: a study of ex ante analysis in large infrastructure policy processes
Authors: Dorren Lars , Van Dooren Wouter 
Published: May 2021

AbstractUsing ex ante analysis to predict policy outcomes is common practice in the world of infrastructure planning. However, accounts of its uses and merits vary widely. Advisory agencies and government think tanks advocate this practice to prevent cost overruns, short-term decision-making and suboptimal choices. Academic studies on knowledge use, on the other hand, are critical of how knowledge can be used in decision making. Research has found that analyses often have no impact at all on decision outcomes or are mainly conducted to provide decision makers with the confidence to decide rather than with objective facts. In this paper, we use an ethnographic research design to understand how it is possible that the use of ex ante analysis can be depicted in such contradictory ways. We suggest that the substantive content of ex ante analysis plays a limited role in understanding its depictions and uses. Instead, it is the process of conducting an ex ante analysis itself that unfolds in such a manner that the analysis can be interpreted and used in many different and seemingly contradictory ways. In policy processes, ex ante analysis is like a chameleon, figuratively changing its appearance based on its environment.
Massive MIMO Systems for 5G Communications
Authors: Khwandah Sinan A. , Cosmas John P. , Lazaridis Pavlos I. , Zaharis Zaharias D. , Chochliouros Ioannis P. 
Published: May 2021

AbstractMassive MIMO will improve the performance of future 5G systems in terms of data rate and spectral efficiency, while accommodating a large number of users. Furthermore, it allows for 3D beamforming in order to provide more degrees of freedom and increase the number of high-throughput users. Massive MIMO is expected to provide more advantages compared to other solutions in terms of energy and spectral efficiency. This will be achieved by focusing the radiation towards the direction of the intended users, thus implementing simultaneous transmission to many users while keeping interference low. It can boost the capacity compared to a conventional antenna solution, resulting in a spectral efficiency up to 50 times greater than that provided by actual 4G technology. However, to take full advantage of this technology and to overcome the challenges of implementation in a real environment, a complicated radio system is required. The purpose of this work is to present the MIMO technology evolution and challenges in a simple introductory way and investigate potential system enhancements.
Combined application of pharyngeal volume and minimal cross-sectional area may be helpful in screening persons suspected of obstructive sleep apnea (OSA)
Authors: Zhao Yuliang , Li Xinyu , Ma Jiangang 
Published: May 2021

AbstractBackgroundObstructive sleep apnea (OSA) is a common disease that seriously affects human health and daily life. However, the gold standard for its diagnosis, polysomnography (PSG), is expensive resulting in inadequate diagnosis of this disease in primary clinics. Therefore, a simple and rapid method for initial screening for OSA is needed. Acoustic pharyngometry (APh) is an FDA-approved noninvasive method that is gradually being applied to screening for OSA.Materials And MethodsIn this study, we applied analysis with receiver operating characteristic (ROC) curves to explore how APh may play a greater role in the screening of subjects with suspected OSA. Patients admitted into the departments of otolaryngology at our hospital from March 2017 to May 2019 were recruited into the study. All subjects underwent PSG monitor and were separated into two groups according to the apnea-hypopnea index (AHI) from the PSG results: OSA group (AHI ≥ 5) and control group (AHI < 5). APh measurements and other indicators of the subjects, including age, height, and weight; Epworth Sleepiness Scale (ESS) score; and the pharynx examination, including the degree of tonsil enlargement and tongue hypertrophy, were also be recorded.ResultsThet-test results showed that almost all indicators except age and height have significant differences between the OSA group and control group. Subjects with OSA had greater weight, BMI, ESS, higher degree of tonsil enlargement, and tongue hypertrophy, while they had smaller minimal cross-sectional area (mCSA) and pharyngeal volume than the subjects in control group. The correlation analysis revealed that pharyngeal volume and mCSA were two helpful indicators to screen for OSA. Furthermore, we established the ROC curve and calculated the combining predictors (combining predictors = pharyngeal volume + mCSA * (− 2.347)/(− 0.225)). The area under the ROC curve (AUC) of combining predictors was 0.917 (95% CI 0.842–0.991,P< 0.001), which was higher than combinations of other two independent indicators. The cutoff point of combining predictors was found to be 59.84 (AUC = 0.917, sensitivity = 0.80, 1-specificity = 0.06,P< 0.001).ConclusionsThese findings suggest that APh is a simple, rapid, and economical detection method which may be useful in screening for OSA, especially in communities and primary clinics where PSG cannot be performed.
Weight Loss Results and Compliance with Follow-up after Bariatric Surgery
Authors: Reiber Beata M. M. , Leemeyer Anna-Marie R. , Bremer Marjolein J. M. , de Brauw Maurits , Bruin Sjoerd C. 
Published: May 2021

Abstract
Purpose
The importance of follow-up (FU) for midterm weight loss (WL) after bariatric surgery is controversial. Compliance to this FU remains challenging. Several risk factors for loss to FU (LtFU) have been mentioned. The aim was therefore to evaluate the association between WL and LtFU 3 to 5 years postoperatively and to identify risk factors for LtFU.

Materials and Methods
A single-center cross-sectional study in the Netherlands. Between June and October 2018, patients scheduled for a 3-, 4-, or 5-year FU appointment were included into two groups: compliant (to their scheduled appointment and overall maximally 1 missed appointment) and non-compliant (missed the scheduled appointment and at least 1 overall). Baseline, surgical, and FU characteristics were collected and a questionnaire concerning socio-economic factors.

Results
In total, 217 patients in the compliant group and 181 in the non-compliant group were included with a median body mass index at baseline of 42.0 and 42.9 respectively. Eighty-eight percent underwent a laparoscopic Roux-en-Y gastric bypass. The median percentage total weight loss for the compliant and non-compliant groups was 30.7% versus 28.9% at 3, 29.3% versus 30.2% at 4, and 29.6% versus 29.9% at 5 years respectively, all p>0.05. Age, persistent comorbidities and vitamin deficiencies, a yearly salary <20,000 euro, no health insurance coverage, and not understanding the importance of FU were risk factors for LtFU.

Conclusion
Three to 5 years postoperatively, there is no association between LtFU and WL. The compliant group demonstrated more comorbidities and vitamin deficiencies. Younger age, not understanding the importance of FU, and financial challenges were risk factors for LtFU.

Graphical abstract
Personality trait differences across types of entrepreneurs: a systematic literature review
Authors: Salmony Florentine U. , Kanbach Dominik K. 
Published: May 2021

AbstractThe personality traits that define entrepreneurs have been of significant interest to academic research for several decades. However, previous studies have used vastly different definitions of the term “entrepreneur”, meaning their subjects have ranged from rural farmers to tech-industry start-up founders. Consequently, most research has investigated disparate sub-types of entrepreneurs, which may not allow for inferences to be made regarding the general entrepreneurial population. Despite this, studies have frequently extrapolated results from narrow sub-types to entrepreneurs in general. This variation in entrepreneur samples reduces the comparability of empirical studies and calls into question the reviews that pool results without systematic differentiation between sub-types. The present study offers a novel account by differentiating between the definitions of “entrepreneur” used in studies on entrepreneurs’ personality traits. We conduct a systematic literature review across 95 studies from 1985 to 2020. We uncover three main themes across the previous studies. First, previous research applied a wide range of definitions of the term “entrepreneur”. Second, we identify several inconsistent findings across studies, which may at least partially be due to the use of heterogeneous entrepreneur samples. Third, the few studies that distinguished between various types of entrepreneurs revealed differences between them. Our systematic differentiation between entrepreneur sub-types and our research integration offer a novel perspective that has, to date, been widely neglected in academic research. Future research should use clearly defined entrepreneurial samples and conduct more systematic investigations into the differences between entrepreneur sub-types.
Current Approach to the Diagnosis and Treatment of Heterozygote and Homozygous FH Children and Adolescents
Authors:   and The Mighty Medic Satellite Research Group for Pediatric Dyslipidemia, Cohen Hofit , Stefanutti Claudia 
Published: May 2021

Abstract
Purpose of Review
To elucidate the current approach of care in pediatric patients with familial hypercholesterolemia (FH). We sought an answer to the question whether the advances and major changes in lipid management are relevant and apply to children and adolescents.

Recent Findings
Latest research findings clearly demonstrate that lowering cholesterol levels at a young age prevents vascular atherosclerotic changes and decreases cardiovascular events in adulthood and emphasizes the importance of early detection and intervention in the pediatric FH patients group.

Summary
FH is a common genetic disease caused by mutations in genes associated with the metabolism of low-density lipoproteins (LDL). The hallmark of FH is elevated LDL cholesterol (LDL-C) levels from birth and premature atherosclerotic cardiovascular disease (ASCVD). Often FH is either undiagnosed or diagnosed with a considerable delay, leading to vascular atherosclerotic changes and cardiovascular disease. Prompt identification of FH subjects is essential, to initiate early preventive measures. Safe and efficient pharmacological agents are approved for use in children and adolescents. Statins are the first line of therapy, in combination of ezetimibe. Unfortunately, these drugs do not warrant the achievement of therapeutic target, especially in HoFH patient. In the latter, lipoprotein apheresis (LA), which has been shown to be safe and effective, is strongly recommended. Finally, the new drugs still under study will allow a multimodal customized treatment. Lowering cholesterol levels at a young age hinders vascular atherosclerotic changes decreasing cardiovascular events in adulthood. Therefore, early detection, diagnosis, and intervention in FH patients are priority objectives.