bluuebunny/crossref_metadata_2025_split huggingface dataset:
Environmental impacts on the design and arts environment for industry 3.0 cotton roller ginning process
Authors: Iyer Vijayan Gurumurthy 
Published: June 2021

The past five decades have been characterised by passage of the environmental impact assessment (EIA) legislation dealing with the environment, including legislation on the control of land, air and water pollution, solid and hazardous waste management, resource conservation and recovery, and soil and ground water and surface water remediation. The aim of this research is to investigate and discuss coronavirus and byssinosis disease impact assessment. Sustainable development is the artistic idea that science and humanities must live and meet their needs without compromising the efficacy and efficiency of future generations to meet their own needs. Prediction and assessment of environmental impacts (effects) on the design and arts environment for industry 3.0 cotton roller ginning process is provided. Sustainable design and arts are discussed in this research work. EIA of conventional design and arts is also investigated. Sustainable design and arts environment for cotton ginning process is presented. The case study and check of strengthening of agricultural extension through sustainable entrepreneurship is discussed in this article.

Keywords: Agriculture, arts, cotton, design, environment, entrepreneurship, ginning, sustainability.
The role of graphic design in the COVID-19 global outbreak
Authors: Atasoy Seda Nur 
Published: June 2021

Many studies have been performed in the field of graphic design to prevent and monitor the coronavirus disease global outbreak, which emerged in Wuhan City, China, and has been announced as a pandemic by the World Health Organisation. Graphic Design has always taken a stand towards positive thinking by enhancing creative reactions to the challenging conditions (conditions in which there is no physical human connection, movement is restricted, concerns increase, etc.) that human beings have faced up so far and has supported the idea of the world that is trying to heal. The aim of this study is to examine the communication power that graphic design has created during the pandemic process by inspecting the current works of a common language which has been put forward as a graphic language in order to be united in the name of graphic design, both in the information charts of the coronavirus in the name of graphic design and in this troubled process of the world. In this study, the reaction, contribution and support, which have been developed by Graphic design for the COVID-19 pandemic process, were examined and samples were presented from designers by examining illustrations, posters, infographics, graphic products and so on, which have been made around the world. In addition to this, creative problem solutions and the role of graphic design have also been explored for solving these problems.

Keywords: Graphic design, COVID-19, coronavirus, outbreak, epidemic.
Art and logo design
Authors: Pascu Nicoleta Elisabeta , Adir Victor , Adir George 
Published: June 2021

This paper aims to present a research study concerning the graphics and symbols in logo design exhibited in an art program dubbed ‘Golden Ages of Art Nouveau and Art Deco’. It was important for us to understand these trends, their characteristics and graphics, to create many times beautiful masterpieces of art. We have noticed a lot of differences between these two art movements related to symbols, signs and colours which were used. It was ‘a special art travel’ to study, theoretically and practically, the field of logo design connected to these ages. Starting from our research study, we have tried to make ‘a basket’ of features which characterises each trend. We have tried to explain the diversity of elements used as an art graphic design focused on logos. And, of course, we have tried to create logos using the features of Art Nouveau and Art Deco.

Keywords: Art Nouveau, Art Deco, logo design, feature, symbols, colours.
The Flipped Classroom: An Overview of its Impact on Economics Learning
Authors: Purba Selvita Eka Eviana , Kristiani Kristiani , Sangka Khresna Bayu , Hussain Omar Khadeer 
Published: June 2021

<div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p><span>The flipped classroom is a type of blended learning that has been widely applied at various levels of education, from elementary to higher, but there have been few studies on its use in Economics education. The purpose of this article is to provide a brief overview of the impact and effectiveness of the flipped classroom on Economics learning. The research methodology used is a literature study with analysis of several articles about the flipped classroom, which concludes with the research objectives. The study results show that the effects of the flipped classroom can enhance student</span><span>s’ </span><span>self-reliant and active learning, increase collaboration, and improve learning outcomes. The article provides advice for educators, especially in the field of Economics education, on use of the flipped classroom to maximise student learning. The study conclusion, which compares the flipped classroom learning model in general, shows that the flipped classroom learning model is effective for use in the learning process because students have studied the material before going to class, meaning the teacher no longer dominates the classroom situation and teacher- student interactions become better and more enjoyable. </span></p></div></div></div>
An improved hazard assessment chart for rock falls in near vertical blocky rock environments
Authors: Sengani Fhatuwani , Francois Mulenga 
Published: June 2021

Abstract
The purpose of the study was to perform rockfall stability analysis and develop an improved rockfall hazard matrix chart using the R518 road in Limpopo as the case study. The study entailed structural mapping, wedge simulation using stereonet plots. The RocFall software was then used to identify the parameters that influence the occurrence of rockfall. The software was also used to monitor the variations in the kinetic energy of rolling, bouncing or falling rocks. The effects of the initial height and velocity of falling rocks on the final destination of fragments were also explored. Results showed that the selected area along the R518 road consists of joints and bedding planes. These features weaken the rock mass and create wedges that can potentially fall. Simulations with RocFall, on the other hand, indicated that slope height, vegetation density, slope angle, the velocity of the falling rock largely contribute to the extent that the broken rock could reach. From the empirical and numerical findings, an improved rockfall hazard rating chart was proposed. The chart was found to be suitable for the rating of level of rockfall hazard along highways and roads.
A study on the effect of pore and particle distributions on the soil water characteristic curve of compacted loess
Authors: Wang Yu , Li Tonglu , Zhao Chenxi , Hou Xiaokun , Li Ping , Zhang Yaguo 
Published: June 2021

Abstract
Compacted loess soil is used as a geo-material in many engineering projects such as building foundations and highway embankments. Water infiltration characteristics and post settlement of the compacted loess in large construction projects of Northwest China have received increasing attention from researchers and investors. These behaviors are closely related to the soil water characteristics. This study aims to investigate the soil water characteristic curves (SWCCs) of compacted loess soil with different dry densities and to reveal the responsible micro-mechanisms for soil water characteristics. Loess soil collected from the new district of Yan'an City, China, is prepared into five dry density groups. The SWCC of each group in the suction range of 0–100,000 kPa is measured using the filter paper method (FPM). Two-dimensional (2D) images and the pore size distribution (PSD) curves of the specimens are tested by scanning electron microscopy (SEM) and the mercury pressure method (MIP), respectively. The results of this study highlight that the compaction behavior mainly influences the pores with a radius ( r ) in the range of 1–10 μm, and has no influence on the pores of r < 0.5 μm. The particle shapes among the five dry densities groups are similar. The characteristics of the PSD curves of the compacted loess soil correspond well to the SWCCs. The suction of the SWCCs increases with increasing dry density in the lower suction range of 0–100 kPa. In contrast, suction among the five dry density groups is almost identical in the suction range exceeding 100 kPa. The results of the study are helpful to understand the SWCC and microstructure characteristics of compacted loess with different dry densities.
Subchronic Exposure to a Glyphosate-Based Herbicide Causes Dysplasia in the Digestive Tract of Wistar Rats
Authors: Serra Fernanda de Maria , Parizi José Luiz Santos , Mello Gisele Aparecida Sales , Sato Grace Mitiko Rosati Hori , Patrão Isabela Bocardi , Chagas Pedro Henrique Nahas , Mello Fabíola de Azevedo , Nai Gisele Alborghetti 
Published: June 2021

Abstract
Glyphosate-based herbicides (GBH) are the most widely used herbicide for treatment of crops in the world. The digestive tract is one of the first systems exposed to pesticides, and damage to this system can affect the general health of individuals. The aim of this study was to evaluate the effects of subchronic inhalation and oral exposure to GBH on the digestive tract in rats. Six groups of Wistar rats (male and female) were exposed to nebulization with three concentrations of GBH [3.71 x 10− 3 grams of active ingredient per hectare (g.a.i./ha), 6.19 x 10− 3 g.a.i./ha, and 9.28 x 10− 3 g.a.i./ha] administered orally or by inhalation for 75 days. Bone marrow cells, smears of the tongue and fragments of the tongue, oesophagus, stomach and intestine were collected for histopathological analysis. Congestion, inflammation, an increase in the number of mast cells and nucleoli-organizing regions were detected in the tongue in the groups exposed to GBH. Females had a higher number of mast cells in the tongue than males. Animals in the groups exposed to higher concentrations of GBH showed dysplasia in the oesophagus and small and large intestine regardless of sex. Gastric changes were not observed. Animals exposed to GBH showed increased micronucleus formation. Our data indicate that GBH causes oral allergies and dysplastic lesions in the oesophagus and small and large intestine and has genotoxic potential.
Waste converting through by-product synergy: an insight from three-echelon supply chain
Authors: Wang Lei , Zhang Qin , Zhang Minhui , Wang Hai 
Published: June 2021

Abstract
By-product synergy (BPS) is an innovative method to convert waste into valuable by-products effectively. Based on a three-echelon supply chain composed of an upstream manufacturer, a processing plant with limited processing capacity, and a downstream manufacturer, this study derives the production quantity and waste disposal decisions of the upstream and downstream manufacturers as well as the optimal transfer price decision of the processing plant. Moreover, we assess the environmental performance of BPS. Analytical results suggest that the upstream manufacturer’s production quantity and waste disposal decisions and the processing plant’s transfer price decision are threshold dependent on the processing plant’s capacity, whereas the downstream manufacturer's production quantity decision is threshold dependent on the processing plant’s capacity and price of raw materials. BPS is beneficial for all members of the supply chain to increase profit. The production promotion and cost-saving effects ensure that the supply chain members maximize their profit. However, BPS does not always have a positive effect on the environment; when the processing plant’s capacity and price of raw materials are below the threshold, implementing BPS results in a win-win situation of economic and environmental benefits.
Evaluation of rockfalls at a historical settlement area in the Ihlara valley (Cappadocia, Turkey) using different methods
Authors: Sari Mehmet 
Published: June 2021

Abstract
Rockfalls are one of the most dangerous natural events in hilly terrains. This study presents the results of an investigation program to analyze the possibility of a rockfall from a slope to nearby residential buildings in a historical settlement area. Various rockfall analysis techniques were implemented in the study for this purpose. The kinematical analysis revealed the potential of different structurally controlled modes of failure in the slope, especially wedge type and block toppling were the most significant ones. Finite element analysis suggested a stable slope considering the safety factor of 2.19 for the existing geological and geotechnical conditions of the studied slope case. A possible rockfall trajectory was determined and located as an input in the 2D rockfall program based on the field measurements. Different shapes and sizes of blocks were used in the rigid body model for a more realistic numerical simulation of rockfall events. According to the 2D model results, there was no danger of rockfall for the investigated downslope buildings. However, to stay on a safe side, a suitable control measure with a specified dimension was proposed to manage rockfalls in the study area.
A YY1 phosphorylation switch in brown adipose tissue orchestrates energy homeostasis.
Authors: Díaz-Hirashi Zyanya , Gao Tian , Scaffidi Chiara , Fey Monika , Murray Susan , Low Audrey , Pushkareva Olga , Rizkallah Raed , Deplancke Bart , Verdeguer Francisco 
Published: June 2021

Abstract
Whole-body energy homeostasis is influenced by anabolic and catabolic cellular programs, which depend on environmental and nutritional cues. Adipose tissue plays a predominant role in the physiological regulation of energy balance by either storing or consuming energy through brown adipose tissue thermogenesis. It is however not clearly understood how brown adipose tissue balances catabolic and anabolic states. We show here that the transcription factor YY1 senses energetic state through a post-translational S120 phosphorylation switch. Adrenergic signaling leads to YY1 dephosphorylation which directly activates thermogenesis and a catabolic gene program while its phosphorylation maintains an anabolic program. Mechanistically, YY1 dephosphorylation increases chromatin binding at distal genomic loci respective to the transcription start site but remains constitutively bound to TSS. This mode of transcriptional control influences the activating and repressive function of YY1 and regulates catabolism/anabolism. We show that YY1 interacts with PPP1R3B, a regulatory subunit of the phosphatase PP1 and that in vivo knockdown of PPP1R3B protects against diet-induced obesity and insulin resistance. Our results uncover a novel transcriptional mechanism of metabolism orchestrated by YY1 phosphorylation switch and identifies PPP1R3B as a regulator of energy balance.
Cys-SH based Quantitative Redox Proteomics of Salt Induced Response in Sugar Beet Monosomic Addition Line M14
Authors: Li Jinna , Ji Meichao , Zhang Tingyue , Yang Chao , Liu He , Chen Sixue , Li Hongli , Li Haiying 
Published: June 2021

Abstract
Background: Salt stress is a major abiotic stress that limits plant growth, development and productivity. Studying the molecular mechanisms of salt stress tolerance may help to enhance crop productivity. Sugar beet monosomic addition line M14 exhibits tolerance to salt stress. Results: In this work, the changes in the BvM14 proteome and redox proteome induced by salt stress were analyzed using a multiplex iodoTMTRAQ double labeling quantitative proteomics approach. A total of 80 proteins were differentially expressed under salt stress. Interestingly, 42 potential redox-regulated proteins showed differential redox change under salt stress. A large proportion of the redox proteins were involved in photosynthesis, ROS homeostasis and other pathways. For example, ribulose bisphosphate carboxylase/oxygenase activase changed in its redox state after salt treatments. In addition, three redox proteins involved in regulation of ROS homeostasis were also changed in redox states. Transcription levels of eighteen differential proteins and redox proteins were profiled. Conclusions: The results showed involvement of protein redox modifications in BvM14 salt stress response and revealed the short-term salt responsive mechanisms. The knowledge may inform marker-based breeding effort of sugar beet and other crops for stress resilience and high yield.
LaOx Modified MnOx Loaded Biomass Activated Carbon and its Enhanced Performance for Simultaneous Abatement of NO and Hg0
Authors: Yi Lei , Xie Jinke , Li Caiting , Shan Jian , Liu Yingyun , Lv Junwen , Li Mi , Gao Lei 
Published: June 2021

Abstract
A battery of agricultural straw derived biomass activated carbons supported LaOx modified MnOx (LaMn/BACs) was prepared by a facile impregnation method and then tested for the efficiency of simultaneous abatement of NO and Hg0. 15%LaMn/BAC manifested excellent removal efficiency of Hg0 (100%) and NO (86.7%) at 180 °C, which also exhibited splendid resistance to SO2 and H2O. The interaction between Hg0 removal and NO removal was explored, thereinto Hg0 removal had no influence on NO removal, while NO removal preponderated over Hg0 removal. The inhibitory effect of NH3 was greater than the accelerative effect of NO and O2 on Hg0 removal. The physicochemical characterization of related samples were characterized by SEM, XRD, BET, H2-TPR, NH3-TPD and XPS. After incorporating suitable LaOx into 15%Mn/BAC, the synergistic effect between LaOx and MnOx contributed to the improvement of BET surface area and total pore volume, the promotion of redox ability, surface active oxygen species and acid sites, inhibiting the crystallization of MnOx. 15%LaMn/BAC has the best catalytic oxidation activity at low temperature. That might be answerable for superior performance and preferable tolerance to SO2 and H2O. Finally, the principle of catalytic oxidation was also discussesed in this article.
Data-driven catalyst optimization for stereodivergent asymmetric synthesis of α-allyl carboxylic acids by iridium/boron hybrid catalysis
Authors: Chen Hongyu , Yamaguchi Shigeru , Morita Yuya , Nakao Hiroyasu , Zhai Xiang-Ning , Shimizu Yohei , Mitsunuma Harunobu , Kanai Motomu 
Published: June 2021

Abstract
Asymmetric catalysis enabling divergent control of multiple stereocenters remains challenging in synthetic organic chemistry. While machine learning-based optimization of molecular catalysis is an emerging approach, data-driven catalyst design to achieve stereodivergent asymmetric synthesis producing multiple reaction outcomes, such as constitutional selectivity, diastereoselectivity, and enantioselectivity, is unprecedented. Here, we report the straightforward identification of asymmetric two-component iridium/boron hybrid catalyst systems for α-C-allylation of carboxylic acids. Structural optimization of the chiral ligands for iridium catalysts was driven by molecular field-based regression analysis with a dataset containing overall 32 molecular structures. The catalyst systems enabled selective access to all the possible isomers of chiral carboxylic acids bearing contiguous stereocenters. This stereodivergent asymmetric catalysis is applicable to late-stage structural modifications of drugs and their derivatives.
The Orthodontic Treatment Scheme for Primary Failure of Eruption Patient without PTH1R Mutation
Authors: Wang Yuhui , Pan Jie , Liu Shangfeng , Liu Yuehua 
Published: June 2021

Abstract
Primary failure of eruption (PFE) is observed as a defect in the tooth eruption mechanism with the heterozygous mutations of parathyroid hormone receptor gene (PTH1R). The present study reported 2 families suffered from nonsyndromic tooth eruption disorder in successive generations. Genetic analysis and standardized assessments, including clinical and radiographic examinations, of the dental condition of all patients were performed to give a clear understanding of the disease. The mutation of PTH1R was detected in patient II-1 (Family I) by PCR and sanger sequencing. Sequencing analysis reviewed heterozygous presence of c.439C>T in exon 2 of PTH1R. According to the UniprotKB database, PTH1R is highly conserved among several mammalian species. RNA-seq was performed to further analyze the role of PTH1R in tooth development and eruption. It showed that during tooth development, the expression of PTH1R decreased in the early stage of tooth development in rat and mouse. However, the mutations of PTH1R were not detected in 2 patients from family II. With extensive analysis of the radiographs and physical examination, we attempted to use orthodontic methods to create enough room for tooth eruption, which shows therapeutic result to the submerged tooth. The results suggested new orthodontic scheme for the PFE patient without PTH1R mutation. Both clinical and genetic diagnosis should be considered in the treatment planning.
Improved electrochemical conversion of CO2 to multicarbon products by using molecular doping
Authors: WU Huali , Li Ji , Qi Kun , Zhang Yang , Petit Eddy , Wang Wensen , Flaud Valerie , Onofrio Nicolas , Rebiere Bertrand , Huang Lingqi , Salameh Chrystelle , Lajaunie Luc , Miele Philippe , Voiry Damien 
Published: June 2021

Abstract
The conversion of CO2 into desirable multicarbon products such as ethylene and ethanol via the carbon dioxide reduction reaction (CO2RR) hold promise to achieve a circular carbon economy. The develop of such a technology is currently hampered by the lack of catalysts, which can drive the reaction at industrially relevant current densities with high efficiency and selectivity. Here, we report a novel strategy for increasing the conversion of CO2 into hydrocarbon molecules with two or more carbon atoms (C2+) by modifying the surface of bimetallic silver-copper (Ag-Cu) catalyst with aromatic heterocycles such as thiadiazole and triazole derivatives. By combining operando Raman and X-ray absorption spectroscopy with electrocatalytic measurements and analysis of the reaction products, we identified that the electron withdrawing nature of functional groups orients the reaction pathway towards the production of C2+ species such as ethanol and ethylene and enhances the reaction rates on the surface of the catalyst. As a result, we achieve a maximum Faradaic efficiency for the formation of C2+ of ≈ 80% and full-cell energy efficiency of 20.3% with a specific current density of 261.4 mA cm-2 for C2+ using functionalized Ag-Cu electrodes, compared to only 33.8% and 70.6 mA cm-2 for the pristine Ag-Cu electrodes. We anticipate that our strategy can further be extended in order to improve the selectivity of the reaction towards the production of specific multicarbon molecules.