bluuebunny/crossref_metadata_2025_split huggingface dataset:
OFICINA DE PROJETO PARAMÉTRICO COLABORATIVO COM ÊNFASE NA CONSTRUTIBILIDADE
Authors: Monteiro Verner , Veloso Maísa , Andrade Heitor 
Published: December 2021

Este texto apresenta os resultados de uma experiência que integrou ações de ensino, pesquisa e extensão, reunindo docentes, pós-graduandos acadêmicos e profissionais da Universidade Federal do Rio Grande do Norte (UFRN), assim como profissionais arquitetos urbanistas e engenheiros civis atuantes internamente (na Superintendência de Infraestrutura) ou externamente a essa instituição. Trata-se de uma Oficina de Projeto Computacional, com foco no projeto paramétrico colaborativo e na construtibilidade dos elementos projetados; no caso, uma cobertura em madeira que atuará como elemento de conexão entre dois edifícios ligados aos cursos graduação e pós-graduação da Arquitetura, no campus central da UFRN, estrutura a ser executada pelo Centro de Tecnologia. O software Rhinoceros, associado ao plugin Grasshopper, foram utilizados como ferramentas de auxílio à concepção de uma forma complexa para essa cobertura considerando uma série de restrições projetuais, inclusive materiais. Foi também dada a possibilidade de utilização do plug-in Karamba3D para cálculo estrutural. Metodologicamente, a Oficina fez uso de um tipo de ateliê integrado de projeto, o multidomínios, utilizando-se de multimeios de concepção e representação, enfatizando na colaboração entre os diferentes agentes participantes. Duas pesquisas científicas embasam essa experiência didática: uma em nível de doutorado centrada na inserção da construtibilidade no processo de projeto com base em parâmetros e outra sobre novas pedagogias do projeto, associando-as, sobretudo, ao uso de recursos computacionais contemporâneos. Além disso, uma ação integrada de extensão permitiu a participação de agentes externos. Após oito encontros foram produzidas seis propostas paramétricas da cobertura em madeira que serão aqui sinteticamente apresentadas e discutidas.
In-silico Screening of Phytoconstituents on Wound Healing Targets -
Approaches and Current Status
Authors: Thomas Asha , Mandale Vijaya , Wavhale Ravindra , Chitlange Sohan 
Published: December 2021

:
Over recent years, there has been tremendous research focused on the effective utilization
of natural products in wound management. Natural or herbal products contain several phytoconstituents
that may act on various stages in wound healing and thereby provide a multi-targeted
approach especially in the treatment of chronic wounds. Currently, attempts have been made to
screen the phytoconstituents present in herbs on various targets involved in wound healing. This review
includes a systematic evaluation of scientific reports by various groups of researchers on the
herbals evaluated for wound management, their phytochemical profiling, pre-clinical studies, and
molecular modeling studies. Various wound targets discussed include Interleukin-1, Interleukin-6,
Tumor necrosis factor-α (TNF-α), Thymosin beta-4 (Tβ-4) that regulate the early inflammatory
stage and the novel T cell immune response cDNA 7(TIRC7) that regulates angiogenesis. Also,
neuropeptides P and Y act on the inflammatory, migratory, and proliferation phases, and growth
factors like vascular endothelial growth factor family (VEGF) and placental growth factor family
(PGF) are involved in angiogenesis, while the role of Fibroblast growth factor in tissue remodeling
is discussed. As many of the natural products include polyherbal systems, this approach can help in
the judicious selection of a combination of herbs that will act on multiple targets in the wound healing
process and provide a multi-factorial approach in wound management.
Prognostic and Therapeutic Values of Autophagy-related Genes in Triple-negative Breast Cancer
Authors: Liu Minling , Li Lei , Huang Shan , Pan Xiaofen , Dai Huiru , Chen Zhe-Sheng , Pan Yihang , Fang Shuo 
Published: December 2021

Background:
Triple-negative breast cancer (TNBC) is a highly aggressive malignancy
with a poor prognosis. Therefore, it is imperative to develop new prognostic or therapeutic biomarkers
for TNBC.

Objective:
To explore the prognostic and therapeutic values of autophagy-related genes (ARGs) in
TNBC.

Methods:
Overall, 157 TNBC patients’ data were obtained from The Cancer Genome Atlas
database, and the ARGs were acquired from the Human Autophagy Database. Differentially expressed
ARGs (DEGs) between tumor and normal tissues were identified, and the prognostic
ARGs were developed using R software. Kaplan-Meier survival curves and receiver operating characteristic
(ROC) curves were both used to evaluate the accuracy of the signature. Patents about
prognostic ARGs were reviewed through Worldwide Espacenet® and Patentscope®.

Results:
We obtained 28 DEGs and two prognostic ARGs (EIF4EBP1 and PARP1). The Kaplan-
Meier survival curves showed that the survival rate of patients with low 2-ARG signature risk
score was significantly higher than that of patients with high-risk score (P =0.003). ROC at 5 years
indicated that the signature had good prognostic accuracy (AUC =0.929). The signature was independent
of T, N, M, and TNM stages (P <0.05). The patent review suggested that many mTOR inhibitors
alone or in combination with another anticancer agent have been provided for the treatment
of many cancers and shown promising results. No drug patents about PARP1 overexpression
were disclosed.

Conclusion:
We developed a 2-ARG signature (EIF4EBP1 and PARP1), which was an independent
prognostic biomarker for TNBC. As EIF4EBP1 was upregulated in TNBC, mTOR inhibitors
which blocked the mTOR/4EBP1/eIF4E pathway, may be a promising therapeutic strategy for TNBC.
Er3+ Incorporated Transparent Ternary Nanocomposite as Active Core
Material in Polymer Optical Preform with Improved Photo-emission Performance
Authors: Chinya Ipsita , Sen Ranjan , Dhar Anirban 
Published: December 2021

Background:
A polymer as a host in the optical waveguide has many advantages and,
when doped with rare-earth (RE) elements, offers an efficient connection, compared to its glassbased
counterparts as an amplifier. However, a polymer matrix causes the concentration quenching
effect of REs in the polymer matrix, making the fabrication of RE-doped polymer waveguides
more complicated as compared to the fabrication of glass-based complements. Moreover, controlling
scattering loss at the particle-polymer interface for maintaining the optical clarity of the
composite is also a great challenge.

Objective:
The main aim of the present study was to optimize the synthesis of Er2O3 grafted Polymethylmethacrylate
(PMMA)-Polystyrene (PS) composite based transparent ternary nanocomposite
and its characterization to implement them as a potential material for active core in Polymer
Optical Preform (POP).

Methods:
Nano Erbium Oxide (Er2O3) was successfully synthesized by the wet-chemical method
and encapsulated by a polymerizable surfactant, i.e., 3-Methacyloxypropyltrimethoxy silane (MPS).
The encapsulated nanoparticles were further subjected to grafting with PMMA using in-situ polymerization
of methyl methacrylate (MMA) followed by blending with PS via solvent mixing technique.

Results:
The optical transparency of the ternary composite was achieved by fine-tuning the diameter
(15-20 nm) of the PMMA coated Er2O3 . The crystallinity present in Er2O3 was significantly reduced
after PMMA coating. The comparatively higher refractive index obtained at 589 nm wavelength
for the synthesized material indicated its usability as active core material in the presence of
a commercial acrylate cladding tube. A photoluminescence (Pl) study indicated that the technique
might be used for a higher level of Er3+ doping in polymer matrix without sacrificing its transparency.

Conclusion:
The obtained results indicated that the sample synthesized with the adopted technique
gives better Pl intensity compared to the other methods of Er3+ incorporation in polymer optical preform
(POP).
ἄριστον μέν ὕδωρ: An Examination of the Public Waterworks in Athens in the Early 5thC BCE
Authors: Vasilodimitrakis-Hart Seraphina 
Published: December 2021

This article examines the design and social impact of waterways in Athens in the early 5thC BCE. While the Athenian political landscape transitioned from a series of tyrannies to democracy at the end of the Archaic period (ca. 650-480 BCE), the archaeological record also shows widespread innovation in the development of public water systems, particularly in sanitation and water supply. A movement away from buildings constructed by the Athenian tyrants facilitated the development of the Classical Agora and the creation of new public-use spaces and structures, like the Southeast Fountain House and the Great Drain in the Agora. The fountain has long been identified with the famous Peisistratid Enneakrounos (“Nine Spouts”) fountain, but through investigation into the arguments of J.M. Camp and Jessica Paga, I propose that a later date ca. 500 BCE is more suitable for the historical and archaeological context of the fountain.
I investigate several Athenian waterworks built/maintained during the late Archaic period to the Classical period (~500-323 BCE): the Great Drain in the Agora, the Southeast Fountain House, the Klepsydra fountain, and the Asklepieion on the Akropolis. The works of Hippocrates, Thucydides, and—to a lesser extent—Pausanias, inform my examination of the implications of the construction of these waterworks and the development of democracy in the 5th century. These waterways show a dedicated shift from the private use of water and tyrannical building works, to a new, fully public and communal mode of engagement with the city and its resources.
Roman and Christian Just War: A Re-Analysis
Authors: Olinski Tim 
Published: December 2021

There is no denying that the early Catholic Church grew up in a climate predominated by a rich and broad religious pantheon. Emerging at first as a perceived outgrowth of Judaism, Christianity was exposed to, among other things, Roman culture. Roman religious practice, which was typically very open to adopting foreign cults, felt threatened by Christianity, resulting in periods of persecution. As a result, the early Christian community had a very complicated relationship with Imperial Rome. The Church stressed non-collaboration, but evidence points that there was a divide between teachings and practice on the topic of military service. The patristic writings of the Early Church fathers are noticeably sparse until Ambrose and Augustine, who present what can generally be called a theory of just war. They also waver between support and condemnation, reflecting the needs of their congregations.
Despite this relative absence of discussion, the prevailing attitude in the historical scholarship of the Early Church was that the pre-Constantine Church pushed for non-collaboration with Roman society, i.e. not serving in public office or the army. After Constantine, that same scholarship points towards an about-face in Church teachings, and a co-opting of the burgeoning Christian community. What this paper seeks to address is that Roman iustum bellum, and Christian just war, were developments specific to their contemporary societies and, while there is definitely a link, the two form distinct systems of thought. One might even say that iustum bellum was more concerned with justifying war, than the moral quandaries of Christian just war.
Growth and survival performance of G2 crossbreeds from two strains of bighead catfish (Clarias macrocephalus)
Authors: Dedan Karanja Njihia , Duong Thuy Yen 
Published: December 2021

The development of bighead catfish (Clarias macrocephalus) aquaculture in Viet Nam has been constrained by the slow growth performance in the domesticated strain. Crossbreeding can be a solution to improve fish production. This study was aimed to evaluate the growth and survival performance of the second generation (G2) fingerlings crossbreeds (CMCT and CTCM) from two bighead catfish strains (wild Ca Mau, CM, and domesticated Can Tho, CT) compared to offspring from their original strains (G0-CT and G0-CM) and G1 crossbreeds (♀CM × ♂CT and ♀CT × ♂CM). The larvae were reared in 50-L tanks (3 to 5 replications) with the density of 1,000 individuals/tank and fed with Moina and artificial feed (40% protein). After 40 days of rearing, the fish grew differently among crosses (P<0.05). In which, the two best-growth groups included CM×CT crossbreeds (body weight of 1,114 mg and length of 4.55 cm) and pure crossbred line CTCM (1,050 mg and 4.51cm, respectively). The CTCM group was recorded the highest survival rate (37.8%) while G0-CT was the lowest (27.2%); however, the difference in survival was not significant (P>0.05). The performance of these crossbreeds should be investigated further at the grow-out stage to see whether crossbreeding between wild and cultured strains of bighead catfish may be used in practice to increase bighead catfish production.
Dampak Penerapan Fasilitasi Sarana Pascapanen Terhadap Kualitas Jagung (Zea mays L.) di Indonesia
Authors: Fitriati Deasy , Ramashinta Vera , Kusumawardhani Hastari 
Published: December 2021

Penelitian yang bertujuan untuk mengevaluasi kualitas jagung setelah penerapan fasilitasi sarana pascapanen dari pemerintah. Kegiatan ini dilaksanakan di sentra produksi jagung di Indonesia pada tahun 2017-2019. Pengumpulan data dilakukan dengan metode survei dan sampel dipilih berdasarkan metode stratified random sampling. Hasil penelitian menunjukkan bahwa mutu jagung di Indonesia berfluktuatif. Kandungan aflatoksin pada sampel 0,05 μg/kg sampai 976,25 μg/kg dan kandungan biji pecah serta rusak 0 sampai 34,40%. Kontaminasi aflatoksin yang berada di atas 150 μg/kg (batas maksimum pada SNI) sebanyak 5% dari total sampel. Di beberapa provinsi, kandungan aflatoksin, kadar air, biji rusak dan biji pecah tidak masuk dalam persyaratan mutu jagung yang terdapat pada SNI. Peningkatan mutu jagung belum menjadi prioritas bagi petani dan pedagang. Karena belum adanya insentif terhadap proses pascapanen yang menjaga mutu hasil produksi. Fasilitasi sarana yang berupa mesin pascapanen diberikan pemerintah kepada petani masih sebatas untuk mengurangi losses. Namun, kualitatif losses belum sesuai dengan target yang diinginkan. Hasil penelitian ini dapat digunakan oleh pembuat kebijakan untuk keberhasilan pelaksanaan program di masa yang akan datang.
Digitisasi Arsip Dalam Rangka Layanan Arsip Statis dalam Jaringan pada Masa Pandemik Covid19
Authors: Setyawan Herman 
Published: December 2021

Munculnya Pandemik Covid19 mempengaruhi aktivitas pada berbagai bidang kehidupan, termasuk layanan akses arsip. Layanan arsip secara konvensional harus diubah menjadi layanan arsip secara digital dalam jaringan guna meminimalkan kontak fisik antarmanusia dalam rangka pencegahan penularan wabah. Tujuan penelitian ini adalah untuk mendeskripsikan proses digitisasi arsip statis, layanan arsip digital dalam jaringan, dan kelebihan dan kekurangan layanan arsip digital dalam jaringan di Arsip universitas Gadjah Mada. Dengan metode deskriptif, penelitian ini menggambarkan bahwa proses digitisasi arsip yang dilakukan di Arsip UGM meliputi berbagai jenis material arsip, serta layanan arsip dilakukan dalam jaringan dengan Sistem Informasi Kearsipan Statis. Selain itu, penelitian ini menggambarkan kelebihan dan kekurangan layanan arsip digital dalam jaringan di Arsip universitas Gadjah Mada.
Physical-mechanical behavior of fresh and completely altered rocks as an important factor of slope instability in the El Rosario Monarch Butterfly Sanctuary, Michoacán, Mexico
Authors: Sánchez-Núñez Juan Manuel , Pola Antonio , Cisneros Guillermo , Sereno Hugo Iván , Serrano-Flores María Elena , Jiménez Luis Ángel , Rodríguez Perla 
Published: December 2021

Slope instability in the Butterfly Biosphere Reserve (RBMM) Michoacán, Mexico, is a widespread phenomenon that results from the complex interaction among different factors such as climate, slope, and the spatial distribution of different rock units. The climate is temperate subhumid, with rains in summer and an annual average rainfall of 700 to 1250 mm. The main physiographic units of the area are volcanic mountains, with slopes greater than 30 degrees. The main scope of this study is to characterize the physical-mechanical properties of fresh and completely altered lower Miocene andesitic lavas of the Sierra de Angangueo (Cerro El Campanario, province of El Rosario, Michoacán) by implementing laboratory tests (bulk density, permeability, porosity, uniaxial compressive strength). The fresh rock sample presents total porosity, permeability, and UCS values of 0.262 mD, 17.1 %, and 63.5 MPa, respectively. Instead, the altered rock display values of 393.71 mD, 60.9 %, and 0.26 MPa. Our results suggest that the slope and the degradation of the rock properties induced by alteration are the conditioning factors of instability in the region. Atypical rainfalls may act as triggering mechanism for slope failure.
Efecto de un programa de educación virtual y pausas activas sobre los hábitos saludables en el personal del Recursos Humanos del Ministerio de Educación Pública durante la pandemia COVID-19
Authors: Vargas-Hernández Diana 
Published: December 2021

Resumen: (1) Antecedentes: dado el contexto actual de pandemia COVID-19 y la realización de teletrabajo, se estableció como objetivo explorar la efectividad de un programa educativo sobre los hábitos de vida de las personas colaboradoras del área de Recursos Humanos (RH) del Ministerio de Educación Pública (MEP) con miras a la implementación de prácticas que lograran un mayor bienestar físico y mental. (2) Métodos: se utilizó un cuestionario elaborado con la herramienta Google Forms. Compuesto por cinco preguntas basadas en el Modelo Transteorético (MT) (Cabrera, 2000) y dos preguntas en el cuestionario PAR-Q & YOU (CSEP, 2002). Asimismo, se realizó una entrevista a la coordinadora de capacitaciones de recursos humanos para obtener información clave para el enfoque de la propuesta.; (3) Resultados: el género femenino fue el de mayor predominancia; cerca de esta población vive sola. Posterior a las sesiones virtuales se presentaron avances positivos en los primeros cuatro estadios de cambio del MT dado que por ejemplo, la población que estaba considerando realizar actividad física en los próximos días aumentó del 89% al 93.9%. Además, antes de la intervención, el 91.3% no presentaban complicaciones cardiovasculares y alrededor de un 40% tenían molestia articular o alguna lesión en la espalda. Resultados: esta intervención fue una oportunidad clave para motivar el cambio hacia un estilo de vida más activo y saludable en las personas colaboradoras del área de RH del MEP. (4) Conclusiones: fue oportuno realizar la intervención y mediar para un cambio positivo hacia la realización de actividad física. Además, el 72.29% confirmaron haber tenido una mejora en la salud tanto física como mental, esta última de gran relevancia en las condiciones de la pandemia actual.
In vitro evaluation of BACtrack®'s smartphone-connected personal breath alcohol analyzers
Authors: Olson Aaron 
Published: December 2021

This study assessed the in vitro accuracy, precision, specificity, and
measurement uncertainty of BACtrack®’s line of smartphone-connected
breath alcohol analyzers. At the 0.080 g/210L ethanol vapor
concentration the measurement uncertainty was determined to be ± 0.013,
0.004, and 0.006 g/210L for the Pro, C8, and C6 respectively at the 95%
coverage interval. The analyzers showed an apparent ethanol response to
isopropanol, and methanol, but not to acetone. BACtrack®’s
smartphone-connected breath alcohol analyzers showed the ability to
measure vaporous ethanol with confidence in the results.
Index60 Identifies Individuals at Appreciable Risk for Stage 3 Among an Autoantibody-Positive Population With Normal 2-Hour Glucose Levels: Implications for Current Staging Criteria of Type 1 Diabetes
Authors: Nathan Brandon M. , Redondo Maria J. , Ismail Heba , Jacobsen Laura , Sims Emily K. , Palmer Jerry , Skyler Jay , Bocchino Laura , Geyer Susan , Sosenko Jay M. 
Published: December 2021

OBJECTIVE
We assessed whether Index60, a composite measure of fasting C-peptide, 60-min C-peptide, and 60-min glucose, could improve the metabolic staging of type 1 diabetes for progression to clinical disease (stage 3) among autoantibody-positive (Ab+) individuals with normal 2-h glucose values (&lt;140 mg/dL).

RESEARCH DESIGN AND METHODS
We analyzed 3,058 Type 1 Diabetes TrialNet Pathway to Prevention participants with 2-h glucose &lt;140 mg/dL and Index60 &lt;1.00 values from baseline oral glucose tolerance tests. Characteristics associated with type 1 diabetes (younger age, greater Ab+, higher HLA DR3-DQ2/DR4-DQ8 prevalence, and lower C-peptide) were compared among four mutually exclusive groups: top 2-h glucose quartile only (HI-2HGLU), top Index60 quartile only (HI-IND60), both top quartiles (HI-BOTH), and neither top quartile (LO-BOTH). Additionally, within the 2-h glucose distribution of &lt;140 mg/dL and separately within the Index60 &lt;1.00 distribution, comparisons were made between those above or below the medians.

RESULTS
HI-IND60 and HI-BOTH were younger, with greater frequency of more than two Ab+, and lower C-peptide levels, than either HI-2HGLU or LO-BOTH (all P &lt; 0.001). The cumulative incidence for stage 3 was greater for HI-IND60 and HI-BOTH than for either HI-2HGLU or LO-BOTH (all P &lt; 0.001). Those with Index60 values above the median were younger and had higher frequency of two or more Ab+ (P &lt; 0.001) and DR3-DQ2/DR4-DQ8 prevalence (P &lt; 0.001) and lower area under the curve (AUC) C-peptide levels (P &lt; 0.001) than those below. Those above the 2-h glucose median had higher AUC C-peptide levels (P &lt; 0.001), but otherwise did not differ from those below.

CONCLUSIONS
Index60 identifies individuals with characteristics of type 1 diabetes at appreciable risk for progression who would otherwise be missed by 2-h glucose staging criteria.
Association Between the ACE Insertion/Deletion Polymorphism and Risk of Lower-Limb Amputation in Patients With Long-Standing Type 1 Diabetes
Authors: Mohammedi Kamel , Abouleka Yawa , Carpentier Charlyne , Potier Louis , Dubois Severine , Foussard Ninon , Rigalleau Vincent , Gautier Jean-François , Gourdy Pierre , Charpentier Guillaume , Roussel Ronan , Scheen André , Bauduceau Bernard , Hadjadj Samy , Alhenc-Gelas François , Marre Michel , Velho Gilberto 
Published: December 2021

OBJECTIVE
The ACE insertion/deletion (I/D) polymorphism has been widely studied in people with diabetes, albeit not with regard to lower-limb amputation (LLA). We examined associations among this polymorphism, plasma ACE concentration, and LLA in people with type 1 diabetes.

RESEARCH DESIGN AND METHODS
ACE I/D genotype and plasma ACE were assessed in three prospective cohorts of participants with type 1 diabetes. LLA was defined as minor (below-the-ankle amputation consisting of at least one ray metatarsal resection) or major (transtibial or transfemoral) amputation. Linear, logistic, and Cox regression models were computed to evaluate the likelihood of prevalent and incident LLA by ACE genotype (XD [ID or ID] vs. II) and plasma ACE, after adjusting for confounders.

RESULTS
Among 1,301 participants (male 54%, age 41 ± 13 years), 90 (6.9%) had a baseline history of LLA. Baseline LLA was more prevalent in XD (7.4%) than in II genotype (4.5%, odds ratio [OR] 2.17 [95 %CI 1.03–4.60]). Incident LLA occurred in 53 individuals during the 14-year follow-up and was higher in XD versus II carriers (hazard ratio 3.26 [95% CI 1.16–13.67]). This association was driven by excess risk of minor, but not major, LLA. The D allele was associated with increased prevalent LLA at the end of follow-up (OR 2.48 [1.33–4.65]). LLA was associated with higher mean (95% CI) ACE levels in II (449 [360, 539] vs. 354 [286, 423] ng/mL), but not XD (512 [454, 570] vs. 537 [488, 586]), carriers.

CONCLUSIONS
This report is the first of an independent association between ACE D allele and excess LLA risk, mainly minor amputations, in patients with type 1 diabetes.