bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUBUNGAN DAN PERAN PEMANGKU KEPENTINGAN POGRAM SMART-KAMPUNG KABUPATEN BANYUWANGI
Authors: Wargadinata Ella Lesmanawaty' 
Published: December 2021

Telah banyak dipahami bahwa penerapan e-government di negara maju memiliki perbedaan sangat tajam dengan penerapannya di negara berkembang. Identifikasi dan peran stakeholders menjadi salah satu faktor penting penentu kesuskesan E-Government di negara berkembang. Tulisan ini mencoba untuk mengungkap kesuksesan program Smart-Kampung yang digagas oleh Pemerintah Kabupaten Banyuwangi , bagaimana Smart-Kampung mengubah wajah pelayanan konvensional menjadi pelayanan digital, dari masyarakat yang lebih terkenal dengan penggemar santet menjadi masyarakat yang lekat dengan internet. Tulisan berfokus pada identifikasi dan peran stakeholders dalam penerapan Smart-Kampung melalui interview, wawancara dan observasi, pengelolahan data menggunakan aplikasi NVivo.12 Hasil temuan memperlihatkan bahwa Pemerintah Kabupaten Banyuwangi secara konsisten menerapkan e-government dengan melibatkan stakeholders yang tepat dan memberi peran yang sesuai dengan kepentingan masing-masing untuk bersama-sama mencapai tujuan e-government, yaitu meningkatkan efisiensi pelayanan pemerintah sekaligus memberi manfaat bagi warga desa. Smart Kampung mampu mengubah birokrasi tradisional melalui pelayanan berbasis TIK. Smart Kampung tidak hanya berhasil memberikan pelayanan administrasi secara online akan tetapi mampu melakukan transformasi social. Hasil kajian memperlihatkan bahwa kunci sukses Smart Kampung terletak pada pembagian tanggungjawab diantara stakeholders yang memiliki kewenangan dan tugas yang berbeda. Kepemimpinan politik tampil sebagai poros dalam hubungan antar stakeholders.
Kata kunci: Pemangku kepentingan, E-Government, pelayanan publik online, birokrasi konvensional, Kepemimpinan Politik
SINKRONISASI ANTARA PERENCANAAN NAGARI DENGAN PERENCANAAN PEMBANGUNAN DAERAH DI KABUPATEN SOLOK
Authors: Agustar Asdi , Syarfi Ira Wahyuni , Wati Elma 
Published: December 2021

Penelitian ini bertujuan untuk mengetahui sinkronisasi perencanaan pada tingkat nagari dengan perencanaan pembangunan pada tingkat kabupaten di Kabupaten Solok dan untuk mengetahui masalah sinkronisasi perencanaan pada tingkat nagari dengan perencanaan pembangunan pada tingkat kabupaten di Kabupaten Solok. Penelitian ini menganalisis dokumen perencanaan pada tingkat nagari yaitu RPJM Nagari Tahun 2013-2019 dan RKP Nagari Tahun 2017-2019 dengan dokumen perencanaan Kabupaten Solok yaitu RPJMD Kabupaten Solok Tahun 2016-2021 dan RKPD Kabupaten Solok Tahun 2017-2019 dengan menggunakan metode studi kasus pada 4 nagari kasus berdasarkan Indek Desa Membangun (IDM) Tahun 2019 yaitu : (1) Nagari Talang (nagari maju), (2) Nagari Aie Batumbuk (nagari berkembang), (3) Nagari Labuah Panjang (nagari tertinggal), dan (4) Nagari Sarik Alahan Tigo (nagari sangat tertinggal) dengan gabungan pendekatan kuantitatif (analisis isi dan analisi pernyataan) dan kualitatif (wawancara dengan informan kunci). Aspek yang dianalisis didalam penelitian ini yaitu visi, misi, tujuan, dan sasaran dari RPJM serta arah kebijakan dalam RKP. Hasil analisis akan dikelompokkan ke dalam empat level tingkat keterkaitan Krippendorff yaitu kuat, sedang, lemah, dan tidak terkait. Hasil dari penelitian ini adalah: (1) visi terkait sedang dengan visi Kabupaten Solok; (2) Misi terkait kuat dengan misi Kabupaten Solok; (3) tujuan terkait lemah dengan tujuan Kabupaten Solok; (4) Sasaran terkait lemah dengan sasaran Kabupaten Solok; dan (5) RKP nagari terkait kuat terhadap RKPD Kabupaten Solok. Masalah dalam sinkronisasi ini terlihat pada lemahnya sumber daya manusia nagari dan tidak adanya monitoring dan evaluasi terhadap dokumen perencana tersebut. Saran dalam penelitian ini adalah perlunya tim indipenden nagari yang besinergi dengan pemerintahan Kabupaten Solok dan adanya pendampingan nagari oleh Kabupaten dalam membuat dokumen perencanaa nagari.
Kata Kunci: Sinkronisasi; Perencanaan; Pembangunan; RPJM; dan RKP
LOKASI POTENSIAL SIMPUL PERSINGGAHAN TRANSPORTASI MENJADI PUSAT PERMUKIMAN PADA KORIDOR KOTA BENGKULU-PERBATASAN SUMATERA SELATAN
Authors: Santoso Eko Budi , Rahmadanita Annisa 
Published: December 2021

Wilayah Provinsi Bengkulu dilalui jalan arteri primer yang berfungsi sebagai sumbu pengembangan yang menghubungkan Kota Bengkulu dengan Kota Palembang, melalui Kota Lubuk Linggau, Kabupaten Rejang Lebong, Kabupaten Kepahiang, dan Kabupaten Bengkulu Tengah. Keberadaan wilayah koridor jalan arteri primer nasional sebagai sumbu pengembangan ini seringkali terabaikan dalam pengembangan wilayah. Penelitian ini dalam rangka untuk memanfaatkan keberadaan kawasan koridor sumbu pengembangan tersebut, dengan melakukan identifikasi dimana saja lokasi potensial simpul persinggahan transportasi (SPT) yang memungkinkan dikembangkan dan yang memiliki ranking potensialitas tinggi untuk dikembangkan menjadi pusat permukiman di sepanjang koridor Kota Bengkulu-Perbatasan Sumatera Selatan? Metode penelitian adalah deskriptif kualitatif. Peneliti berusaha memotret kondisi nyata yang ada di lapangan dengan menyertakan bukti-bukti otentik dari berbagai teknik pengumpulan data yang dilakukan, dengan mendasarkan pengambatan berdasarkan indikator yang telah ditentukan berbasis teori Development Axes (Pottier, 1963 dalam Hilhorst, 1972) dan teori perkembangan SPT pada SP (Santoso, 2014). Kesimpulan penelitian ini bahwa pada Koridor jalan arteri primer Kota Bengkulu-bts Sumsel (Lubuk Linggau), terdapat 48 lokasi potensial pengembangan SPT menjadi Pusat Permukiman (yg lebih besar) dengan 28 fungsional dan 20 potensi. Di wilayah Kota Bengkulu terdapat 5 lokasi potensial dgn 4 fungsional dan 1 lokasi masih potensi. Di Kabupaten Bengkulu Tengah Terdapat 23 lokasi potensial dgn 14 fungsional dan 10 potensi. Di Kabupaten Kepahiang terdapat 7 lokasi potensial dgn 4 fungsional dan 3 potensi. Di Kabupaten Rejanglebong terdapat 15 lokasi potensial, dgn 9 fungsional dan 6 potensi. Adapun rekomendasi terkait dengan adanya perbedaan perkembangan dan fungsionalitas lokasi potensial, Pemda Kab/kota dan Provinsi perlu menyusun Strategi yang berbeda-beda untuk tiap jenis lokasi potensial terkait dengan perkembangan dan kelemahan yg ada.
Kata Kunci: Lokasi Potensial, Simpul Persinggahan Transportasi, Pusat Permukiman.
EFEKTIVITAS PERAN BAPPEDA DALAM PERENCANAAN PEMBANGUNAN INFRASTRUKTUR DI PASAR SORE TAPIOKA KELURAHAN SIRIWINI DISTRIK NABIRE KABUPATEN NABIRE PROVINSI PAPUA
Authors: Mulyana Mulyana , Arfayan Manuel Pieter Stenly 
Published: December 2021

Pasar Sore Tapioka merupakan sektor perekonomian yang memiliki kondisi fisik atau infrastruktur dengan kategori buruk. Kondisi bangunan seperti ini membuat masyarakat membutuhkan sentuhan pemerintah untuk membangun pasar tersebut. Penelitian ini bertujuan untuk mendeskripsikan dan menganalisis efektivitas peran Bappeda dalam perencanaan pembangunan infrastruktur di Pasar Sore Tapioka Kelurahan Siriwini, Distrik Nabire, Kabupaten Nabire. Penelitian ini menggunakan metode deskriptif kualitatif. Pengumpulan data dilakukan melalui wawancara, observasi, dokumentasi. Pemilihan informan didasarkan pada teknik purposive sampling. Hasil penelitian menunjukkan bahwa Efektivitas Peran Bappeda dalam Perencanaan Pembangunan belum efektif. Sesuai dengan indikator teori efektivitas, dimana masih belum maksimalnya koordinasi antar stakeholder terkait untuk melaksanakan pembangunan di Pasar Sore Tapioka. Kemudian, masyarakat pelaku ekonomi juga merasa belum puas dengan pembangunan pasar tersebut yang kurang memadai, hal ini disebabkan karena Pasar Sore Tapioka belum memiliki data teknis atau sertifikat tanah yang jelas. Sertifikat ini menjadi landasan pelaksanaan perencanaan pembangunan maupun pengembangan Pasar Sore Tapioka karena akan menggunakan anggaran negara. Untuk itu, pembangunan dan pengembangan Infrastruktur di Pasar Sore Tapioka ini seyogyanya dilaksanakan, serta pengkinian data kepemilikan tanah anggota masyarakat perlu ditegakkan. Dengan demikian, tertib administrasi pertanahan menjadi modal utama dalam menyukseskan pembangunan Infrastruktur di Pasar Sore Tapioka.
Kata Kunci: Efektivitas, Perencanaan Pembangunan, Peran Bappeda, Pembangunan Berkelanjutan,Kabupaten Nabire
A Label-Free Electrochemical Immunosensor for CEA Detection on a Novel Signal Amplification Platform of Cu2S/Pd/CuO Nanocomposites
Authors: Cao Linlin , Zhang Wen , Lu Sumei , Guo Chengjie , Wang Peijun , Zhang Dantong , Ma Wanshan 
Published: December 2021

Carcinoembryonic antigen (CEA) is regarded as one of the crucial tumor markers for colorectal cancer. In this study, we developed the snowflake Cu2S/Pd/CuO nanocomposite to construct an original label-free electrochemical immunosensor for the ultrasensitive detection of CEA levels. The nanocomposite of cuprous sulfide (Cu2S) with Pd nanoparticles (Pd NPs) was synthesized through an in situ formation of Pd NPs on the Cu2S. Cuprous sulfide (Cu2S) and CuO can not only be used as a carrier to increase the reaction area but also catalyze the substrate to generate current signal. Palladium nanoparticles (Pd NPs) have excellent catalytic properties and good biocompatibility, as well as the ability of excellent electron transfer. The immunosensor was designed using 5 mmol/L H2O2 as the active substrate by optimizing the conditions with a detection range from 100 fg/ml to 100 ng/ml and a minimum detection limit of 33.11 fg/ml. The human serum was detected by electrochemical immunoassay, and the results were consistent with those of the commercial electrochemical immunosensor. Therefore, the electrochemical immunosensor can be used for the detection of human serum samples and have potential value for clinical application.
Implications of Multiple Disequilibrium Textures in Quartz-Hosted Embayments
Authors: Ruefer Anna C. , Befus Kenneth S. , Thompson James O. , Andrews Benjamin J. 
Published: December 2021

The faces of volcanic phenocrysts may be marked by imperfections occurring as holes that penetrate the crystal interior. When filled with glass these features, called embayments or reentrants, have been used to petrologically constrain magmatic ascent rate. Embayment ascent speedometry relies on the record of disequilibrium preserved as diffusion-limited volatile concentration gradients in the embayment glass. Clear, glassy embayments are carefully selected for speedometry studies. The use and subsequent descriptions of pristine embayments overrepresent their actual abundance. Here, we provide a textural analysis of the number, morphology, and filling characteristics of quartz-hosted embayments. We target a collection of large (i.e., &gt;20 km3 erupted volume) silicic eruptions, including the Bishop Tuff, Tuff of Bluff Point, Bandelier Tuff, Mesa Falls Tuff, and Huckleberry Ridge Tuff in the United States, Oruanui Tuff in New Zealand, Younger Toba Tuff in Indonesia, the Kos Plateau Tuff in Greece, and the Giant Pumice from La Primavera caldera in Mexico. For each unit, hundreds of quartz crystals were picked and the total number of embayment-hosting crystals were counted and categorized into classifications based on the vesicularity and morphology. We observed significant variability in embayment abundance, form, and vesicularity across different eruptions. Simple, cylindrical forms are the most common, as are dense glassy embayments. Increasingly complex shapes and a range of bubble textures are also common. Embayments may crosscut or deflect prominent internal cathodoluminescence banding in the host quartz, indicating that embayments form by both dissolution and growth. We propose potential additional timescales recorded by embayment disequilibrium textures, namely, faceting, bubbles, and the lack thereof. Embayment formation likely occurs tens to hundreds of years before eruption because embayment surfaces are rounded instead of faceted. Bubble textures in embayments are far from those predicted by equilibrium solubility. Homogenous nucleation conditions likely allow preservation of pressures much greater than magmastatic inside embayments. Our textural observations lend insight into embayment occurrence and formation and guide further embayment studies.
Craniofacial and Craniocervical Features in Cartilage-Hair Hypoplasia: A Radiological Study of 17 Patients and 34 Controls
Authors: Arponen Heidi , Evälahti Marjut , Mäkitie Outi 
Published: December 2021

BackgroundBiallelic mutations in the non-coding RNA gene RMRP cause Cartilage-hair hypoplasia (CHH), a rare skeletal dysplasia in which the main phenotypic characteristic is severe progressive growth retardation.ObjectiveThis study compared the cranial dimensions of individuals with CHH to healthy subjects.MethodsLateral skull radiographs of 17 patients with CHH (age range 10 to 59 years) and 34 healthy individuals (age range 10 to 54 years) were analyzed for relative position of the jaws to skull base, craniofacial height and depth, as well as vertical growth pattern of the lower jaw, anterior cranial base angle, and the relationship between the cervical spine and skull base.ResultsWe found that the length of the upper and lower jaws, and clivus were significantly decreased in patients with CHH as compared to the controls. Anterior cranial base angle was large in patients with CHH. Basilar invagination was not found.ConclusionThis study found no severe craniofacial involvement of patients with CHH, except for the short jaws. Unexpectedly, mandibular deficiency did not lead to skeletal class II malocclusion.Clinical ImpactAlthough the jaws were shorter in patients with CHH, they were proportional to each other. A short posterior cranial base was not associated with craniocervical junction pathology.
Lactobacillus acidophilus Supplementation Exerts a Synergistic Effect on Tacrolimus Efficacy by Modulating Th17/Treg Balance in Lupus-Prone Mice via the SIGNR3 Pathway
Authors: Kim Da Som , Park Youngjae , Choi Jeong-Won , Park Sung-Hwan , Cho Mi-La , Kwok Seung-Ki 
Published: December 2021

ObjectiveTacrolimus (Tac) is an immunosuppressant used in the treatment of systemic lupus erythematosus (SLE); however, it induces T cell subset imbalances by reducing regulatory T (Treg) cells. Lactobacillus acidophilus (LA) is reported to have therapeutic efficacy in immune-mediated diseases via T cell regulation.MethodsThis study investigated whether a combination therapy of LA and Tac improves the therapeutic efficacy of Tac by modulating T cell subset populations in an animal model of SLE. Eight-week-old MRL/lpr mice were orally administered with 5 mg/kg of Tac and/or 50 mg/kg of LA daily for 8 weeks. Cecal microbiota compositions, serum autoantibodies levels, the degree of proteinuria, histological changes in the kidney, and populations of various T cell subsets in the spleen were analyzed.ResultsMice presented with significant gut dysbiosis, which were subsequently recovered by the combination treatment of Tac and LA. Double negative T cells in the peripheral blood and spleens of MRL/lpr mice were significantly decreased by the combination therapy. The combination treatment reduced serum levels of anti-dsDNA antibodies and Immunoglobulin G2a, and renal pathology scores were also markedly alleviated. The combination therapy induced Treg cells and decreased T helper 17 (Th17) cells both in vitro and in vivo. In vitro treatment with LA induced the production of indoleamine-2,3-dioxygenase, programmed death-ligand 1, and interleukin-10 via the specific intracellular adhesion molecule-3 grabbing non-integrin homolog-related 3 receptor signals.ConclusionThe present findings indicate that LA augments the therapeutic effect of Tac and modulates Th17/Treg balance in a murine model of SLE.
The Impact of Postponed Fertility Treatment on the Sexual Health of Infertile Patients Owing to the COVID-19 Pandemic
Authors: Dong Meng , Wu Shanshan , Tao Yanqiang , Zhou Feifei , Tan Jichun 
Published: December 2021

Background: With the onset of the coronavirus disease 2019 (COVID-19) pandemic at the beginning of 2020, all non-essential medical treatments were suspended, including fertility treatments. As a unique group in society, patients with infertility may be more sensitive and vulnerable in the face of pressure and crisis. However, to the best of our knowledge, there have been no reports on the influence of postponed fertility treatment on the sexual health of infertile patients owing to COVID-19. Therefore, this study aimed to investigate whether postponed fertility treatment resulting from COVID-19 affects the sexual health of patients with infertility.Methods: A total of 1,442 participants were included for analysis in this large-scale study. Those with postponed fertility treatment were categorised as group A (n = 474), whereas those whose fertility treatment was not delayed were in group B (n = 968). The sexual health and psychological well-being were compared between the two groups.Results: The total Female Sexual Function Index score and five domains of female sexual function (arousal ability, vaginal lubrication, orgasm, satisfaction, and coital pain) were significantly lower in group A than those in group B (p &lt; 0.05). The International Index of Erectile Dysfunction score and Premature Ejaculation Diagnostic Tool score were significantly higher in group A than those in group B (p &lt; 0.05).Conclusions: Delaying fertility treatment obviously affects patients' sexual and mental health. Through a structural equation model, we observed that postponed fertility treatment mediates sexual health by regulating psychological distress and couple relationship quality.
Long Non-coding RNAs Gabarapl2 and Chrnb2 Positively Regulate Inflammatory Signaling in a Mouse Model of Dry Eye
Authors: Yang Yuhan , Chen Minjie , Zhai Zimeng , Dai Yiqin , Gu Hao , Zhou Xujiao , Hong Jiaxu 
Published: December 2021

Purpose: To elucidate the expression profile and the potential role of long non-coding ribonucleic acids (RNAs) (lncRNAs) in a dry eye disease (DED) model.Methods: A DED model was established in C57BL/6J mice with 0.2% benzalkonium chloride (BAC) twice a day for 14 days. The differentially expressed lncRNAs were detected by RNA-seq technology (Gene Expression Omnibus, GEO GSE186450) and the aberrantly expressed lncRNAs were further verified by RT-qPCR. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted to predicate the related candidate genes and potential pathological pathways. Cells from a human corneal epithelial cell line (HCECs) were cultured under hyperosmolarity. The regulation of inflammatory factors by silencing potential targeted lncRNAs was verified in vitro in HCECs.Results: In our study, a significant increase in corneal fluorescence staining and a reduction in tear production were observed in DED mice at all follow-ups compared with the controls, and the differences were increasing over time. In total, 2,649 upregulated and 704 downregulated lncRNAs were identified in DED mice. We selected six aberrantly expressed and most abundant lncRNAs and performed RT-qPCR using the samples for RNA-seq. Chrnb2, Gabarapl2, and Usp31 were thereby confirmed as the most significantly altered lncRNAs. Pathway analysis revealed that the neuroactive ligand–receptor interaction signaling pathway was the most enriched, followed by the calcium signaling pathway and cytokine–cytokine receptor interaction. Following treatment of Gabarapl2 siRNA and Chrnb2 siRNA, tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 were significantly downregulated in the HCECs.Conclusion: Our study suggests that Chrnb2 and Gabarapl2 may be involved in the inflammation response by regulating TNF-α, IL-1β, and IL-6 in DED. These candidate lncRNAs may be both potential biomarkers and therapeutic targets for DED.
Zinc Oxide Nanoparticles Prime a Protective Immune Response in Galleria mellonella to Defend Against Candida albicans
Authors: Xu Mei-nian , Li Li , Pan Wen , Zheng Huan-xin , Wang Meng-lei , Peng Xiao-ming , Dai Si-qi , Tang Ying-mei , Zeng Kang , Huang Xiao-wen 
Published: December 2021

Purpose: Zinc oxide nanoparticles (ZnO-NPs) have exerted antimicrobial properties. However, there is insufficient evaluation regarding the in vivo antifungal activity of ZnO-NPs. This study aimed to investigate the efficacy and mechanism of ZnO-NPs in controlling Candida albicans in the invertebrate Galleria mellonella.Methods:Galleria mellonella larvae were injected with different doses of ZnO-NPs to determine their in vivo toxicity. Non-toxic doses of ZnO-NPs were chosen for prophylactic injection in G. mellonella followed by C. albicans infection. Then the direct in vitro antifungal effect of ZnO-NPs against C. albicans was evaluated. In addition, the mode of action of ZnO-NPs was assessed in larvae through different assays: quantification of hemocyte density, morphology observation of hemocytes, characterization of hemocyte aggregation and phagocytosis, and measurement of hemolymph phenoloxidase (PO) activity.Results: Zinc oxide nanoparticles were non-toxic to the larvae at relatively low concentrations (≤20 mg/kg). ZnO-NP pretreatment significantly prolonged the survival of C. albicans-infected larvae and decreased the fungal dissemination and burden in the C. albicans-infected larvae. This observation was more related to the activation of host defense rather than their fungicidal capacities. Specifically, ZnO-NP treatment increased hemocyte density, promoted hemocyte aggregation, enhanced hemocyte phagocytosis, and activated PO activity in larvae.Conclusion: Prophylactic treatment with lower concentrations of ZnO-NPs protects G. mellonella from C. albicans infection. The innate immune response primed by ZnO-NPs may be part of the reason for the protective effects. This study provides new evidence of the capacity of ZnO-NPs in enhancing host immunity and predicts that ZnO-NPs will be attractive for further anti-infection applications.
Case Report: HSV-2 Encephalitis Presenting With Chorea; Effects of Infection Alone or Combination of Infection and Autoimmunity?
Authors: Kolesnik Michael , Ballout Ahmad A. , Hameed Natasha , Najjar Souhel 
Published: December 2021

Background: Chorea as a symptom of late-onset post-infectious autoimmune encephalitis has been reported with HSV-1 but not HSV-2 encephalitis. Extrapyramidal symptoms are typically associated with the presence of anti-NMDA receptor antibodies but may also exist in antibody-negative individuals.Case: This case highlights a patient who presented with mental status changes and chorea as the initial manifestation of HSV-2 encephalitis. The choreiform movements failed to respond to antiviral medications but were rapidly responsive to plasmapheresis, which, together with abnormal intrathecal immunoglobulin synthesis, suggests a potential contribution of parainfectious immune-mediated process. The patient made a full recovery and a complete resolution of the chorea.Discussion: This is the first case associating HSV-2 encephalitis presentation with chorea. The neurological complications, including chorea, are largely related to active CNS HSV-2 infection, possibly together with triggered CNS autoimmunity despite undetectable CSF neuronal autoantibodies and normal neuroimaging. Early diagnosis and treatment with antiviral agent and immune therapies might be pivotal to optimize the clinical outcome.