bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Prenatal Exposure to Titanium Dioxide Nanoparticles on DNA Methylation and Gene Expression Profile in the Mouse Brain
Authors: Tachibana Ken , Kawazoe Shotaro , Onoda Atsuto , Umezawa Masakazu , Takeda Ken 
Published: October 2021

Background and Objectives: Titanium dioxide nanoparticles (TiO2-NP) are important materials used in commercial practice. Reportedly, TiO2-NP exposure during pregnancy can affect the development of the central nervous system in mouse offspring; however, the underlying mechanism remains unknown. In the present study, we investigated the impact of prenatal TiO2-NP exposure on global DNA methylation and mRNA expression patterns in the brains of neonatal mice.Materials and Methods: Pregnant C57BL/6J mice were intratracheally administered a TiO2-NP suspension (100 μg/mouse) on gestational day 10.5, and brains were collected from male and female offspring at day 1 postpartum. After extraction of methylated DNA by immunoprecipitation, the DNA methylation profile was analyzed using a mouse CpG island microarray. Total RNA was obtained, and mRNA expression profiles were comprehensively assessed using microarray analysis.Results: Among genes in the CpG island microarray, DNA methylation was increased in 614 and 2,924 genes and decreased in 6,220 and 6,477 genes in male and female offspring, respectively. Combined with mRNA microarray analysis, 88 and 89 genes were upregulated (≥1.5-fold) accompanied by demethylation of CpG islands, whereas 13 and 33 genes were downregulated (≤0.67-fold) accompanied by methylation of CpG islands in male and female offspring mice, respectively. Gene Set Enrichment Analysis (GSEA) revealed that these genes were enriched in gene ontology terms related to the regulation of transcription factors, cell proliferation, and organism development. Additionally, MeSH terms related to stem cells and morphogenesis were enriched.Conclusion: Prenatal TiO2-NP exposure induced genome-wide alterations in DNA methylation and mRNA expression in the brains of male and female offspring. Based on GSEA findings, it can be speculated that prenatal TiO2-NP exposure causes adverse effects on brain functions by altering the DNA methylation state of the fetal brain, especially neural stem cells, resulting in the subsequent abnormal regulation of transcription factors that modulate development and differentiation.
DAMPAK PSIKOLOGIS NARAPIDANA SEUMUR HIDUP DALAM PERUBAHAN PIDANANYA MENJADI PIDANA PERCOBAAN 20 TAHUN
Authors: Fitranto Rico , Subroto Mitro 
Published: October 2021

A prisoner is someone whose rights and freedoms must be revoked because he has committed a crime. The loss of freedom of freedom, and the things that must be faced in the face of the environment and the new, and having to part with loved ones, as well as relatives, which negatively affects actions. This study aims to determine the psychological development with a life sentence against a criminal change into a 20-year probationary sentence. This writing uses a normative approach using library techniques. Many with life sentences experienced despair and lost hope, the change of sentence to 20 years probation was a second chance that was coveted by the people. In serving the sentence, there are three important parts that have a large enough influence on the condition of a psychologist, namely environmental conditions in prisons, characteristics between individuals and social support.
Pengaruh Pendidikan Kesehatan Menggunakan Media Video Dan Alat Peraga Terhadap Pengetahuan Dan Sikap Remaja Putri Tentang Personal Hygiene Pada Masa Menstruasi Dalam Layanan Homecare
Authors: Suseno Mutiara Rachmawati , Fitri Hamidiyanti Bq Yuni , Ayu Ningsih Winda 
Published: October 2021

Abstrak

Latar Belakang : Angka insiden penyakit infeksi yang terjadi pada saluran reproduksi pada remaja (10-18 tahun), yaitu 35 sampai 42 persen serta dewasa muda (18-22 tahun) sebesar 27 hingga 33 persen. Misal, kurangnya tindakan merawat kebersihan organ reproduksi ketika menstruasi. Berdasarkan studi pendahuluan yang dilakukan di Desa Kumbung wilayah kerja Puskesmas Kuripan Lombok Barat, kepada 10 remaja putri secara wawancara didapatkan hasil 9 remaja putri belum pernah terpapar mengenai personal hygiene masa menstruasi da 1 orang sudah pernah terpapar tentang personal hygiene masa menstruasi.
Tujuan Penelitian : untuk mengetahui adanya pengaruh pendidikan kesehatan menggunakan media video dan alat peraga terhadap pengetahuan dan sikap remaja putri dalam personal hygiene masa menstruasi
Metode Penelitian : Jenis penelitian ini adalah Pre Experimental dengan desain One Group Pretest-Posttest. Populasi penelitian ini adalah remaja putri dengan jumlah sampel 30 orang. Analisis data yang digunakan dalam penelitian ini menggunakan analisis non parametrik wilcoxon.
Hasil Penelitian : Hasil nilai pengetahuan sebelum diberikan pendidikan kesehatan didapatkan remaja putrid memiliki tingkat pengetahuan dalam kategori cukup yaitu sebanyak 18 orang (60%) dan sesudah diberikan pendidikan kesehatan didapatkan remaja putri banyak yang memiliki tingkat pengetahuan dalam kategori baik sebanyak 29 orang (97%). Remaja putri sebelum diberikan pendidikan kesehatan memiliki sikap dalam kategori baik sebanyak 19 orang(63%) dan sesudah diberikan pendidikan kesehatan remaja putrid yang memiliki sikap dalam kategori baik bertambah menjadi 27 orang (90%). Setelah dilakukan uji statistic diperoleh nilai p value = 0,000 atau p< α = 0,05, yang berarti ada pengaruh.
Kesimpulan : Terdapat pengaruh pendidikan kesehatan menggunakan media video dan alat peraga terhadap pengetahuan dan sikap remaja putri tentang personal hygiene masa menstruasi.
Kata Kunci : video dan alat peraga, personal hygiene masa menstruasi.
STRUKTUR IKLAN PARFUM ECLAT FOR MEN PADA KATALOG ORIFLAME
Authors: Dewa Ayu Kadek Claria  , I Gusti Ngurah Adi Rajistha  
Published: October 2021

ABSTRACT
The purpose of this research is to identify “The structure of Eclat for Men’s Perfume in Oriflame Catalogue” because the structure is an interesting topic to discuss. The problem analyzed in this research is what kinds of structure found in Eclat for Men’s Perfume found in Oriflame Catalogue. The theory used in this research is theory by Leech about structure of advertisement which consists of headline, body copy, signature line dan standing details. This research is also limited on commercial advertisement on men’s perfume entitled Eclat for Men’s which is obtained from the Oriflame Catalogue. The result shows that Eclat for Men’s Perfume has a complete structure. They are headline, illustration, body copy, signature line dan standing details. For the next research commercial advertisement on electronic media should be reviewed in the terms of semiotic.
Keywords: Text, Systemic Functional Linguistics, Commercial Advertisement
Diagenesis of paleodrainages in Lake Way and Lake Maitland, Western Australia, and the role of authigenic Mg-clays and dolomite in the genesis of channel and playa uranium deposits
Authors: Drummond Justin B. R. , Kyser T. Kurt , Bowell Robert R. , James Noel P. , Layton-Matthews Daniel 
Published: October 2021

ABSTRACT
This study integrates mineralogical and hydrogeochemical analysis of channel and playa uranium deposits to characterize aquifer evolution and the physico-chemical mechanisms that result in the accumulation of uranium into potentially economic deposits. This subset of surficial U deposits occur in Tertiary to Recent calcrete and dolomitic, clay-rich fluvial paleochannel and palustrine sediments, wherein uranium is largely bound in the potassium-uranyl-vanadate mineral carnotite [K2(UO2)2(VO4)2·3H2O].
Scanning electron microanalysis indicates that the carnotite mineralization is part of a late-diagenetic mineral assemblage that critically includes Mg-clays (sepiolite and stevensite), amorphous magnesium silicate, and synsedimentary dolomite. This authigenic mineral assemblage is observed concentrated in fractures and pores in groundwater calcrete and silty salt marsh “palustrine” sediments. Drill-hole gamma ray and conductivity data from the Centipede-Millipede uranium deposit indicate that the locus of uranium mineralization occurs near the present-day water table where oxidizing fresh-to-brackish groundwater interacts with playa brine, forming a hypopycnal groundwater estuary beneath the clay pan and salt marsh. It is interpreted that effective U fixing occurs in areas where groundwater, near-saturated with respect to carnotite, is hydrologically focused upward and into the zone of evaporation. The appreciable precipitation deficit in the Northern Yilgarn is interpreted to produce an evaporation-driven positive feedback mechanism that results in the co-precipitation of Mg-clays, dolomite, and carnotite. The presence of vanadium-rich Mn-oxide phases in high-grade U ore zones indicates that Mn-redox cycling may serve an important role in increasing the local activity of V, and thus carnotite saturation. Mineralogical comparison of other channel and playa uranium deposits throughout Western Australia and Namibia have identified a similar mineral association and paragenetic trend, suggesting that contemporaneous evaporative precipitation of Mg-clays and dolomite are integral in achieving carnotite saturation and precipitation.
Dendrogeochemistry and soil geochemistry applied to exploration for alkalic Cu-Au porphyry mineralization under cover at the Racecourse prospect, NSW, Australia
Authors: McGill Cole , Layton-Matthews Daniel , Kyser T. Kurt , Leybourne Matthew I. , Polito Paul , Leduc Evelyne 
Published: October 2021

ABSTRACTThe Racecourse Cu-Au porphyry prospect is found within the Macquarie Arc of the Lachlan Fold Belt, in the Lachlan Transverse Zone, a cross-arc structure hosting significant world-class mineralization, including the Cadia and Northparks districts. Several geochemical and geophysical surveys of the prospect have been complimented by a total of 19,819 m of drilling, with only four holes reaching a depth greater than 300 m. Positive lithogeochemistry (fertility indices, comparisons with the Cadia and Northparks systems) subtle alteration, and mineralized intercepts indicate heightened mineral potential, yet the prospect has lacked a comprehensive geochemical survey outlining the extent of the mineralized target at surface. Soil samples and Monterey pine (Pinus radiata) tree cores were collected above and distal to mineralization intercepted by prior drilling in order to outline the ore deposit footprint and test the viability of dendrogeochemistry as an exploration tool for porphyry Cu mineralization. Ultimately, this study documented the spatial extent of the Racecourse target and identified potential areas for additional Cu mineralization. Soil samples were separated with the &lt;250 μm size fraction analyzed and show distinct anomalous populations of Au, Cu, Mo, Pb, and Zn above prior drilling. Tree cores were collected by increment borer and tree rings of the Pinus radiata were counted and measured, with an age interval of 2003–2008 exhibiting the least ring-width variability chosen to chemically analyze. Selected intervals were digested and analyzed and have elevated Cu, Mo, and Zn in an area that overlaps a previously drilled soil anomaly, whereas an anomaly in the southwest of the survey area documents a Cu, Pb anomaly corresponding to localized faulting and tertiary basalt subcrop. Tree roots are directly tapping chemical variability at depth, aided via metal mobilization through faulted fluid conduits. Lead isotope ratios from the Pinus radiata identify distinct groups of lead spatially associated with discrete metal anomalies of varied lithological ages. At the Racecourse target, anomalous Pinus radiata samples yield a similar isotopic signature to the faulted southwestern anomaly, potentially linking the source of these two metal anomalies. When these results are integrated with the current understanding of the mineralized body, geochemical media suggest that mineralization may continue down-plunge at depth.
Alteration mineralogy and pathfinder element inventory in the footprint of the McArthur River unconformity-related uranium deposit, Canada
Authors: Joyce Nicholas , Layton-Matthews Daniel , Kyser Kurt , Leybourne Matthew , Ansdell Kevin , Kotzer Tom , Quirt David , Zaluski Gerard 
Published: October 2021

ABSTRACTPathfinder elements associated with the exploration footprint of the McArthur River unconformity-related U deposit include U, radiogenic Pb, V, Ni, Co, Cu, Mo, As, Zn, and rare earth elements. In this study, the mineralogical and paragenetic context for their occurrence was established by integrating in situ mineral chemistry and laser ablation mass spectrometry chemical mapping of interstitial assemblages, detrital grains, and cements with whole-rock analyses of drill core samples from the diagenetically altered background and the hydrothermally altered sandstone host rocks. Diagenetically altered background sandstones contain a matrix assemblage of illite and dickite, with trace to minor aluminum-phosphate-sulfate (APS) minerals, apatite, and Fe-Ti oxide minerals. Aluminum-phosphate-sulfate minerals account for the majority of the Sr and light rare earth element concentrations, whereas early diagenetic apatite, monazite, and apatite inclusions in detrital quartz and detrital zircon contribute significant U and heavy rare earth elements to samples analyzed with an aggressive leach (partial digestion) such as aqua regia. Hydrothermally altered sandstone host rocks also contain variable assemblages of Al-Mg chlorite (sudoite), alkali-deficient tourmaline, APS minerals, kaolinite, illite, Fe-oxide, and sulfide minerals. Late pre-mineralization chlorite accounts for a significant portion of the observed Ni concentrations, whereas Co, Cu, Mo, and Zn occur predominantly in cryptic sub-micron sulfide and sulfarsenide inclusions within clay mineral aggregates and in association with Fe-Ti oxides. Elevated concentrations of U were observed in cryptic micro-inclusions associated with sulfides in quartz overgrowths, with Fe-Ti oxide micro-inclusions in kaolinite, and in post-mineralization Fe-oxide veins. The distribution of pathfinder elements throughout the deposit footprint appears to be less related to the primary dispersion of alteration minerals from the hydrothermal system than to the secondary dispersion of elements post-mineralization. Their occurrence throughout pre-, syn-, and post-mineralization assemblages further demonstrates the limitations to defining geochemical footprints from pathfinder element concentrations expressed in lithogeochemical data sets without structural, lithological, and mineralogical context.
Paleoredox conditions, hydrothermal history, and target vectoring in the MacMillan Pass base-metal district, Yukon, Canada: 1 – Lithogeochemistry of proximal and distal shales
Authors: Leighton Claire , Leybourne Matthew I. , Layton-Matthews Daniel , Peter Jan M. , Gadd Michael G. , Voinot Alexandre 
Published: October 2021

ABSTRACT
The MacMillan Pass District in Yukon, Canada, hosts the Tom and Jason clastic sediment-hosted Zn-Pb-Ag-(Ba) deposits. Bulk geochemical paleoredox proxies (Eu/Eu*, Ce/Ce*, Mo, Re/Mo, and Ni/Co) indicate anoxic–dysoxic water column and sulfidic porewater conditions persisted during the Late Devonian deposition of the Lower Earn Group host rocks. Positive Eu/Eu* anomalies (up to 3.31) in sulfide mineralization at the Tom deposit are consistent with relatively high temperature (probably &gt;250 °C), reducing, acidic hydrothermal fluids that infiltrated laterally through unconsolidated sediments proximal to the hydrothermal upflow zone and/or exhaled at the seafloor as moderate- to high-density brines. Molybdenum and U enrichment factors (relative to upper continental crust) and Mo/organic C values are consistent with a moderately restricted basin; Mo/C values fall between those of the Black Sea (highly restricted) and the Framvaren Inlet (moderately restricted). A Ba-rich shale was identified in rocks that are distal and time-equivalent units to the Pb-Zn mineralization; based on the bulk chemical compositions and on previous S and Sr isotope studies, we interpret the baryte in this unit to be largely hydrothermal in origin and perhaps remobilized and reprecipitated during hydrothermal base-metal mineralization.
Application of molybdenum and thallium isotopes as indicators of paleoredox conditions and genesis of hyper-enriched black shale deposits, Peel River, Yukon, Canada
Authors: Crawford Isobel , Layton-Matthews Daniel , Peter Jan M. , Gadd Michael G. , Voinot Alexandre , Leybourne Matthew I. , Pufahl Peir 
Published: October 2021

ABSTRACT
Hyper-enriched black shale (HEBS) deposits in northern Yukon, consist of thin (&lt;10 cm), laterally extensive (tens of thousands of km2) stratiform sulfide mineralization layer(s) that are hyper-enriched in Ni, Mo, Zn, platinum group elements, Re, and Au. The genesis of HEBS deposits and the ambient paleoenvironment in which they formed are the subject of vigorous debate. Non-traditional stable isotopes, particularly molybdenum and thallium, are robust paleoredox indicators and we have employed these isotope systems in this study of Yukon HEBS. Systematic sampling and Mo and Tl isotopic analysis of a continuous 200 m stratigraphic section through the Yukon HEBS mineralization and footwall and hanging-wall strata at the Peel River north and south bank showings (spaced five km apart) give δ98Mo –1.24 to –0.53‰ and –8.1 to –5.2 ε-units for the mineralization and –0.70 to 0.60‰ and –6.5 to –2.0 ε-units for the unmineralized strata. These values preclude a hydrothermal origin and strongly suggest that redox processes were responsible for the Yukon HEBS mineralization. The isotopic compositions, together with rare earth element (REE) systematics (REE profile, Y positive anomalies, Ce negative anomalies, and Y/Ho values) and other bulk geochemical redox indicators (Mo, V, Re/Mo, Ni/Co, U/Th, and V/Cr) indicate that the Peel River HEBS mineralization formed because of metal scavenging from seawater in a quiescent, euxinic basinal paleoenvironment.
L’adulatio principis de Tacite et les séances du Sénat sous le principat de Tibère
Authors: Barrandon Nathalie 
Published: October 2021

L’adulatio principis en tant que thème politique permit à Tacite d’affiner son regard sur le comportement des sénateurs du Ier siècle ap. J.-C. Ce type de flatterie rend non seulement compte de l’amitié politique propre à une cour impériale mais aussi de la dérive possible du pouvoir vers une monarchie aux accents hellénistiques. Pendant le principat de Tibère, elle fut à l’œuvre dans la curie. L’ordre du jour des séances, le contenu de l’adulatio, les relations entre les auteurs de l’adulatio et l’empereur et les réactions de ce dernier témoignent du pragmatisme de Tibère, qui n’avait pas seulement dû enfiler le costume d’Auguste, mais aussi renforcer son contrôle de la domus Augusta et sa prééminence à la tête de l’Empire.
Nomina, tituli et loci : en quête d’une définition des personae du princeps
Authors: Benoist Stéphane 
Published: October 2021

À partir de la documentation épigraphique, et nourri par les données complémentaires de la numismatique et de la littérature gréco-latine, cet essai envisage les différentes personae des empereurs romains afin de définir la nature des postures impériales sur une longue durée, d’Auguste au ive siècle de notre ère. La polysémie du mot persona enrichit la portée de cette réflexion, entre personnage ou caractère de théâtre et degré de l’ordre successoral. Sont ainsi analysées les titulatures impériales, et notamment leurs enseignements à propos des noms (nomina), titres et fonctions (tituli) des empereurs romains. Quelques aspects d’une mise en scène du discours impérial par les mots, images et cérémonies urbaines dans l’espace de la cité de Rome (ces loci du paysage politique, enjeux de l’exécution des rituels du politique) sont enfin brièvement abordés afin de rendre compte de l’identité du princeps, construite pas à pas, d’un magistrat, primus inter pares, à un souverain paré des vertus philosophiques légitimant son pouvoir dans l’empire.
Caracalla : un manteau pour un empereur
Authors: Badel Christophe 
Published: October 2021

L’historiographie moderne estime que l’empereur Caracalla (211-217) tire son surnom d’un manteau gaulois adopté lors de la guerre germanique de 213 et distribué ensuite à la plèbe romaine. En fait, cette interprétation fait la synthèse de deux traditions textuelles, Dion Cassius et les historiens latins du IVe siècle, qui s’avèrent contradictoires. Chez les historiens contemporains du prince, Hérodien ne mentionne pas le sobriquet et Dion Cassius ne le cite qu’après sa mort, parmi d’autres dénominations. Ce sont les historiens latins de l’Antiquité tardive qui l’utilisent systématiquement, lui conférant une valeur identitaire. Pour Dion Cassius, le manteau fut porté par le prince et distribué aux soldats pendant la guerre parthique de 216-217. Il ressemblait à une lacerna, manteau léger proche de la chlamyde. Pour les historiens latins, il fut distribué à la plèbe romaine à une date incertaine (213 ?) et s’apparentait à une paenula, lourd manteau proche du corps. En fait, il semble que le manteau distribué aux soldats ait été une cape iranienne mais divisée en carreaux selon le style gaulois. La polarisation des auteurs tardifs sur le surnom Caracalla s’explique par la volonté de trouver un substitut à son cognomen officiel d’Antonin, renvoyant à la figure idéale du bon empereur, dont cet empereur n’était pas jugé digne par le milieu sénatorial.
Les mains du prince
Authors: Rey Sarah 
Published: October 2021

Dans le droit romain, la manus indique la puissance accordée au père et au chef de famille. Elle exprime l’idée de force et de possession. La main fait partie du vocabulaire juridique et donc mental des Romains ; c’est peut-être la raison pour laquelle les historiens et les biographes se montrent très attentifs aux mains des empereurs. Ces dernières semblent posséder leur autonomie et révéler des tempéraments. Tantôt métonymie du bon gouvernement, tantôt miroir de la tyrannie, les mains laissent deviner la teneur d’une politique. Les mauvais princes abusent de leur force, se perdent en gesticulations, s’abandonnent à toutes les formes d’adulation et de mollesse : leurs mains en témoignent. Les bons princes, quant à eux, comprennent les enjeux de la « chironomie », cette loi de la main énoncée par Quintilien : ils disciplinent leur main et la rendent secourable. Pour renforcer cette démarcation, les dieux se servent des mains comme messagères à travers les prodiges, les rêves, les statues et les sacrifices. Les empereurs et leurs mains se retrouvent alors au contact de la divinité, pour le meilleur et pour le pire.
L’empereur et l’armée sous le Principat
Authors: Le Bohec Yann 
Published: October 2021

La vie politique dans l’empire romain se jouait à quatre : empereur, Sénat, peuple de Rome et armée. L’empereur avait des moyens pour s’attacher les soldats : des honneurs, la religion, les discours et des avantages concrets (argent et privilèges juridiques). Il disposait aussi de la contrainte (punitions). Les soldats, en retour, soutenaient l’empereur contre le Sénat et contre des compétiteurs dans les guerres civiles. Mais ils pouvaient aussi le combattre s’ils l’estimaient inférieur à sa tâche.
Un panthéon de femmes exemplaires. Giuseppe Betussi, Boccace et les femmes illustres au xvie siècle
Authors: Bartuschat Johannes 
Published: October 2021

La contribution analyse le Libro delle donne illustri de Giuseppe Betussi (1545). Il s’agit de la traduction italienne du De mulieribus claris de Boccace, enrichie d’une additione qui comprend cinquante biographies supplémentaires de femmes ayant vécu pour la plupart après la mort de Boccace. Notre étude insère le texte de Betussi à la fois dans l’histoire de la réception de l’ouvrage de Boccace et dans le contexte de la littérature sur les femmes célèbres au xvie siècle. Une étude approfondie de l’additione permet de souligner les différences dans l’approche de la biographie qui pour Betussi doit posséder une valeur exemplaire et qu’il développe dans le sens d’un éloge de la vertu féminine.