bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating Differences in Elastic Modulus of Regenerated and Uninjured Mouse Digit Bone through microCT Density-Elasticity Calculation and Nanoindentation Testing
Authors: Hoffseth Kevin F , Busse Emily , Lacey Michelle , Sammarco Mimi C 
Published: July 2021

AbstractBone is an essential, healing structure in vertebrates that ensures daily function. However, the regenerative capacity of bone declines with age, compromising quality of life in the elderly and increasing cost of care. Here, for the first time, the elasticity of regenerated bone in a mouse digit amputation model is evaluated in order to better investigate biomechanics of skeletal regeneration. Amputation of the distal one third of the digit (third phalangeal element – P3) results in de novo regeneration of the digit, where analyzing the structural quality of this regenerated bone is a challenging task due to its small scale and triangular shape. To date, the evaluation of structural quality of the P3 bone has primarily focused on mineral density and bone architecture. This work describes an image-processing based method for assessment of elasticity in the whole P3 bone by using microcomputed tomography-generated mineral density data to calculate spatially discrete elastic modulus values across the entire P3 bone volume. Further, we validate this method through comparison to nanoindentation-measured values for elastic modulus. Application to a set of regenerated and unamputated digits shows that regenerated bone has a lower elastic modulus compared to the uninjured digit, with a similar trend for experimental hardness values. This method will be impactful in predicting and evaluating the regenerative outcomes of potential treatments and heightens the utility of the P3 regenerative model.
Crosstalk with keratinocytes causes GNAQ oncogene specificity in melanoma
Authors: Urtatiz Oscar , Haage Amanda , Tanentzapf Guy , Van Raamsdonk Catherine D. 
Published: July 2021

ABSTRACTDifferent melanoma subtypes exhibit specific and non-overlapping sets of oncogene and tumor suppressor mutations, despite a common cell of origin in melanocytes. For example, activation of the Gαq/11signaling pathway is a characteristic initiating event in primary melanomas that arise in the dermis, uveal tract or central nervous system. It is rare in melanomas arising in the epidermis. Here, we present evidence that in the mouse, crosstalk with the epidermal microenvironment actively impairs the survival of melanocytes expressing the GNAQQ209Loncogene, providing a new model for oncogene specificity in cancer. The presence of epidermal cells inhibited cell division and fragmented dendrites of melanocytes expressing GNAQQ209Lin culture, while they promoted the growth of normal melanocytes. Differential gene expression analysis of FACS sorted epidermal melanocytes showed that cells expressing GNAQQ209Lexhibit an oxidative stress and apoptosis signature previously linked to vitiligo. Furthermore, PLCB4, the direct downstream effector of Gαq/11signaling, is frequently mutated in cutaneous melanoma alongside P53 and NF1. Our results suggest that a deficiency of PLCB4 promotes cutaneous melanomagenesis by reducing GNAQ driven signaling. Hence, our studies reveal the flip side of the GNAQ/PLCB4 signaling pathway, which was hitherto unsuspected. In the future, understanding how epidermal crosstalk restrains the GNAQQ209Loncogene could suggest novel melanoma therapies.
Corrosion behavior of carbon steel in H2S-CO2-H2O-methyldiethanolamine (MDEA) solution under the presence of chloride ions
Authors: Wu Guiyang , Gu Xikui , Zhao Wanwei , Fan Rui , Mao Ting 
Published: July 2021

PurposeThis paper aims to study the effect of chloride ions concentration on the corrosion behavior of carbon steel in methyldiethanolamine (MDEA) aqueous solution in the sight of different process parameters of purification plant.Design/methodology/approachDue to the decrease of filtration efficiency and separation efficiency, the chloride ion in the desulfurization solution is enriched. The corrosion behavior of carbon steel under chloride ion enrichment environment was studied by weight-loss method, electrochemical impedance spectroscopy, cyclic polarization curve, X-ray photoelectron spectroscopy and scanning electron microscopy.FindingsThe results show that temperature and hydrogen sulfide loads are the main factors of corrosion in CO2-MDEA-H2O-H2S environment. The enrichment of chloride ions reduces the corrosion rate at low temperature but promotes the corrosion rate at high temperature. The chloride concentration should be controlled below 3000 mg/L, and no pitting corrosion was found under the experimental conditions.Originality/valueThe effect of chloride ion enrichment on MDEA solution corrosion shows that at low temperature, the increase of chloride ion will reduce the acid gas load and increase the density of corrosion products, so as to reduce the corrosion; on the contrary, at high temperature, the density of corrosion products will decrease and the corrosion will be intensified as well. It is believed that the chloride ion should be controlled below 3000 mg/L according to the results of the tests.
Barriers for homeless with dual diagnosis: lessons learned from intensive mobile psychosocial assertive community treatment program
Authors: Zolnikov Tara Rava , Hammel Michael , Furio Frances , Eggleston Brandon 
Published: July 2021

PurposeDual diagnosis is a term that describes the co-occurrence of mental health disorders or illness and substance use or abuse disorders. Because this co-occurrence results in multiple diseases, layers of treatment are often needed to successfully create positive change in the individual. The purpose of this study is to explore factors of treatment that could facilitate improvements in functionality and quality of life for those with a dual diagnosis.Design/methodology/approachA secondary data analysis, using both quantitative and qualitative data, was completed. Secondary analysis is an empirical exercise that applies the same basic research principles as studies using primary data and has steps to be followed, including the evaluative and procedural steps commonly associated with secondary data analysis. Documentation data from the intensive mobile psychosocial assertive community treatment program was gathered for this analysis; this program was used because of the intensive and community-based services provided to patients with a dual diagnosis.FindingsThe major findings from this secondary analysis suggested that significant barriers included “denial” (e.g. evasion, suspension or avoidance of internal awareness) of diagnoses, complicated treatment and other barriers related to housing. Ultimately, these findings provided greater insight into potential effective treatment interventions for people living with a dual diagnosis.Originality/valueThis study adds to the growing body of literature showing that patient-centered care allows for more effective treatment and ultimately, improved health outcomes.
Multi-objective optimization of a spoke-type permanent magnet motor with fractional-slot concentrated windings for EVs
Authors: Liu Suying , Huang Jinlin 
Published: July 2021

Purpose
This paper aims to propose a spoke-type fractional-slot concentrated windings (FSCW) PM machine for EVs driving system to improve torque density. To further improve electromagnetic performance, the multi-objective optimization design is processed based on response surface (RS) model and simulated annealing cuckoo search (SA-CS) algorithm.

Design/methodology/approach
The spoke-type FSCW PM machine is designed and optimized to meet the requirement of EVs driving system. First, a spoke-type FSCW PM machine is designed and some of key parameters are obtained based on equivalent magnetic circuit (EMC) method. Then, the RS model and modified SA-CS algorithm are proposed to obtain higher torque, lower torque ripple and higher efficiency.

Findings
After verification by finite element method for no-load and load performance, the optimal machine has higher torque density, lower torque ripple and higher efficiency compared with initial machine. Finally, a 20 kW prototype is manufactured and tested to verify the validity of the proposed optimization design method.

Originality/value
This paper designs a high torque density spoke-type FSCW PM machine, which is superior for EVs driving system. Meanwhile, a novel modified SA-CS algorithm is applied to the field of electrical machine multi-objective optimal design.
Digital preservation in institutional repositories: a systematic literature review
Authors: Barrueco José Manuel , Termens Miquel 
Published: July 2021

Purpose
This paper aims to carry out a literature review on the implementation of digital preservation policies, strategies and actions by institutional repositories. The objective is to identify, out of the published experiences, at which level they are fulfilling the function of ensuring the long-term availability of the deposited materials.

Design/methodology/approach
Using a systematic literature review methodology, a total of 21 articles from international refereed journals published between 2009 and 2020 are reviewed.

Findings
The research production on this subject is very limited. The scarce number of published articles proves that the interest of repository managers has been focused on issues other than to assure the long-term availability of the assets they store. The literature review has not found clear evidence about how institutional repositories are implementing digital preservation. It is particularly striking the lack of works focused on the situation in European countries. More field studies are needed. They would allow to extract conclusions and produce best practices to help managers to improve preservation strategies.

Originality/value
This study has shown that one of the main functions of repositories is not being dealt with as promised by repository managers. More work in this area is needed. In particular, it is necessary for a study at the European level to gather detailed data that will allow to draw a portrait of the current situation, extract conclusions and produce best practices to help managers to improve or develop preservation strategies.
Multilateral development banks: understanding their impact on start-up development in Latin America
Authors: Dams Carolina , Sarria Allende Virginia , Murcia María José 
Published: July 2021

Purpose
This paper aims to examine the relative performance of multilateral development banks venture capital funds (MDBVCs) compared to that of government-sponsored venture capital funds (GVCs), assessing their impact on invested start-ups.

Design/methodology/approach
First, the authors survey the literature to understand the performance drivers of public programs designed to foster venture capital (VC). Second, the authors analyze the characteristics of multilateral development banks (MDBs) VC-related efforts. Third, based on their goals, structure, governance and management processes, the authors propose and test the hypothesis that MDBs initiatives outperform comparable public programs, overcoming the main limitations of the latter.

Findings
The authors find that start-ups funded by MDBVCs outperform GVC-funded start-ups in terms of access to subsequent financing and international expansion. Consistent with previous studies, the authors find that start-ups funded by private VCs show the highest levels of performance.

Originality/value
The paper features an unstudied actor – i.e. MDBVCs-, and an unstudied region – i.e., Latin America-, using a unique data set of 437 start-ups that received VC investments in 7 Latin American countries during the study period 2000–2018.
“Most Americans like their privacy.” Exploring privacy concerns through US guests’ reviews
Authors: D’Acunto David , Volo Serena , Filieri Raffaele 
Published: July 2021

Purpose
This study aims to explore US hotel guests’ privacy concerns with a twofold aim as follows: to investigate the privacy categories, themes and attributes most commonly discussed by guests in their reviews and to examine the influence of cultural proximity on privacy concerns.

Design/methodology/approach
This study combined automated text analytics with content analysis. The database consisted of 68,000 hotel reviews written by US guests lodged in different types of hotels in five European cities. Linguistic Inquiry Word Count, Leximancer and SPSS software were used for data analysis. Automated text analytics and a validated privacy dictionary were used to investigate the reviews by exploring the categories, themes and attributes of privacy concerns. Content analysis was used to analyze the narratives and select representative snippets.

Findings
The findings revealed various categories, themes and concepts related to privacy concerns. The two most commonly discussed categories were privacy restriction and outcome state. The main themes discussed in association with privacy were “room,” “hotel,” “breakfast” and several concepts within each of these themes were identified. Furthermore, US guests showed the lowest levels of privacy concerns when staying at American hotel chains as opposed to non-American chains or independent hotels, highlighting the role of cultural proximity in privacy concerns.

Practical implications
Hotel managers can benefit from the results by improving their understanding of hotel and service attributes mostly associated with privacy concerns. Specific suggestions are provided to hoteliers on how to increase guests’ privacy and on how to manage issues related to cultural distance with guests.

Originality/value
This study contributes to the hospitality literature by investigating a neglected issue: on-site hotel guests’ privacy concerns. Using an unobtrusive method of data collection and text analytics, this study offers valuable insights into the categories of privacy, the most recurrent themes in hotel guests’ reviews and the potential relationship between cultural proximity and privacy concerns.
The US shale oil production, market forces and the US export ban
Authors: Taneri Ilayda , Dogan Nukhet , Berument M. Hakan 
Published: July 2021

PurposeThe purpose of this paper is to use the novel data from the primary vision to determine the main financial and economic drivers of this revolutionary shale oil production and how these drivers changed after 2016 when the US removed its oil-exporting ban.Design/methodology/approachIn this paper, the authors use the vector autoregressive model to assess the dynamic relationships among the Frac Count (FSCN) from the primary vision and the set of financial/macro-economic variables and how this dynamic relationship is altered with the effects of the US export ban before and after the lifting of the export ban.FindingsThe empirical evidence reveals that a positive shock to New York Mercantile Exchange, Standard and Poor’s 500, rig count, West Texas Intermediate or the US ending oil stocks increase the FSCN but higher interest rates and oil production decrease the FSCN. After the US became one of the major oil producers, it removed its crude export ban in December 2015. The empirical evidence suggests that the shale oil industry gets more integrated with the financial system and becomes more efficient in its production process in the post-2016 era after the export ban was removed.Originality/valueThe purpose of this paper is to use the novel data from the primary vision to determine the main financial and economic drivers of this revolutionary shale oil production and how these drivers changed after 2016 when the US removed its oil-exporting ban.
Effectiveness of industry-university-research cooperation in China: impact of innovation input and open innovation environment
Authors: Xia Huosong , Weng Juan , Zhang Justin 
Published: July 2021

Purpose
Industry–university–research cooperation (IURC) is a crucial way to build an innovative country. How to improve the effectiveness of IURC has become an important issue to be solved urgently.

Design/methodology/approach
This paper studies the data of industry, university and research activities in various regions of China from 2016 to 2018 and analyzes the impact mechanism of innovation input and open innovation environment on the effectiveness of IURC based on innovation value chain theory.

Findings
This research finds that innovative talent input has an inverted U-shaped impact on the effectiveness of IURC. When there are more innovative funds invested, the marginal effect of IURC will decrease. When innovative talent input exceeds a certain value, the open innovation environment can alleviate the positive marginal effect of its decline.

Originality/value
This paper contributes to the literature and provides practical guidelines for improving the efficacy of IURC.
The impact of the work-family conflict on employee engagement, performance, and turnover intention
Authors: Ribeiro Neuza , Gomes Daniel , Oliveira Ana Rita , Dias Semedo Ana Suzete 
Published: July 2021

Purpose
The incompatibility between the sphere of work and the family is a reality that plagues many workers today. The difficult articulation of these two domains leads to the experience of the phenomenon called work–family conflict (WFC). This paper aims to assess the impact that WFC may have on employee engagement and performance, as well as on their turnover intention. It is also intended to test the mediating effect of engagement on the relationship between WFC and performance, and between WFC and the turnover intention.

Design/methodology/approach
One hundred and sixty-seven employees from various Portuguese organizations were surveyed. Respondents reported their perceptions of own WFC, engagement, performance and turnover intention.

Findings
The results revealed that employees who feel a higher WFC have lower levels of engagement and greater intention to leave the organization. The WFC showed no relation to performance. Engagement takes on the mediating role in the relationship between WFC and the turnover intention.

Practical implications
The relevance of this study is related to the implications that it may bring to companies in the context of implementing work–family balance strategies to reduce the referred conflict.

Originality/value
This study contributes to WFC literature by attempting to integrate in the same model four concepts in a single study to provide a model that depicts the chain of effects between WFC, engagement, individual performance and turnover intention, which has never been done in the Portuguese context.
Lean production systems, social sustainability performance and green competitiveness: the mediating roles of green technology adoption and green product innovation
Authors: Afum Ebenezer , Sun Zhuo , Agyabeng-Mensah Yaw , Baah Charles 
Published: July 2021

Purpose
This study aims to investigate the interrelationships between lean production, green technology adoption, green product innovation, social sustainability performance and green competitiveness. The study further investigates the mediation roles of green technology adoption and green product innovation between lean production systems, social sustainability performance and green competitiveness.

Design/methodology/approach
The quantitative research approach is used for the study. Data for the study is garnered from 197 managers of manufacturing firms in Ghana via a self-administered questionnaire. Structural equation modeling, specifically partial least square is applied as the methodological tool to test all hypotheses.

Findings
Results of the study suggest that lean production systems have a significant positive impact on green technology adoption, green product innovation and green competitiveness. However, lean production systems are found to have an insignificant impact on social performance. The results further confirm the mediation roles of both green technology adoption and green product innovation between lean production systems, social sustainability performance and green competitiveness; thus indicating that lean production systems create an efficient condition for firms to adopt green technologies and produce innovative green-based products to leverage superior social sustainability performance and green competitiveness.

Originality/value
This study proposes and develops a comprehensive research model that is supported by the natural resource-based view theory to investigate the link between lean production systems, green technology adoption, green product innovation, social sustainability performance and green competitiveness from an emergent country perspective.
Does trust in zakat institution enhance entrepreneurs’ zakat compliance?
Authors: Bin-Nashwan Saeed Awadh , Abdul-Jabbar Hijattulah , Aziz Saliza Abdul 
Published: July 2021

Purpose
Although zakat is a principal way to redistribute wealth, a unique practice designed to achieve a sustainable Islamic economic and social system, zakat institutions and agencies in most Muslim countries still suffer from the perplexing issue of low zakat collections, ascribing this to the level of compliance among zakat payers. To provide more insight into this lacuna, this study aims to examine the role of trust in zakat institution through the relationship between socio-economic determinants (i.e. religiosity, moral reasoning, peer influence and system fairness) and zakat compliance decisions.

Design/methodology/approach
From a typical Islamic country, Yemen, a random sample of 274 entrepreneurs was drawn for a self-administered survey. To estimate and analyze the compliance model, SmartPLS structural equation modeling was used.

Findings
The results show that all hypothesized direct relationships are supported. Importantly, the trust-moderated interactions of religiosity, moral reasoning and peer influence on zakat compliance are significant, although its interaction with zakat system fairness is not.

Practical implications
The results should be helpful for policymakers and responsible institutions in Muslim communities to understand how different levels of trust can play an important role in Zakat payers’ compliance to boost or erode zakat funds. This research also contributes important inferences for managers about the necessity of inculcating religious and moral values among zakat payers, formulating a fair system and embarking on sensitization programs in society.

Originality/value
The research enriches the scanty literature by validating a viable compliance model drawing on the socio-economic theory of regulatory compliance. Moreover, the model integrates the moderating role of trust in socio-economic perspectives of zakat compliance.