bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angle-insensitive co-polarized metamaterial absorber based on equivalent circuit analysis for dual band WiFi applications
Authors: Hannan Saif , Islam Mohammad Tariqul , Faruque Mohammad Rashed Iqbal , Chowdhury Muhammad E. H. , Musharavati Farayi 
Published: July 2021

AbstractA novel and systematic procedure to design a co-polarized electromagnetic metamaterial (MM) absorber with desired outputs and resonance frequencies for dual-band WiFi signal absorption is presented. The desired resonance frequencies with expected S parameters' values were first designed as an equivalent circuit with extensive analysis and then implemented into frequency-selective MM absorber by numerical simulation with precise LRC elements, satisfying least unit cell area (0.08λ), substrate thickness (0.01λ) and maximum effective medium ratio (12.49). The absorber was simulated for the maximum angle of incidence for both the normal and oblique incidences at co-polarization. The absorptions at the desired resonance frequencies were found at a satisfactory level by both simulation and practical measurement along with a single negative value to ensure metamaterial characteristics. The proposed equivalent circuit analysis approach can help researchers design and engineering co-polarization insensitive MM absorbers using conventional split-ring resonators, with perfection in output and desired resonance frequencies without the necessity of lumped elements or multilayer substrates. The proposed metamaterial can be utilized for SAR reduction, crowdsensing, and other WiFi-related practical applications.
Structural plasticity of mumps virus nucleocapsids with cryo-EM structures
Authors: Shan Hong , Su Xin , Li Tianhao , Qin Yuqi , Zhang Na , Yang Liuyan , Ma Linsha , Bai Yun , Qi Lei , Liu Yunhui , Shen Qing-Tao 
Published: July 2021

AbstractMumps virus (MuV) is a highly contagious human pathogen and frequently causes worldwide outbreaks despite available vaccines. Similar to other mononegaviruses such as Ebola and rabies, MuV uses a single-stranded negative-sense RNA as its genome, which is enwrapped by viral nucleoproteins into the helical nucleocapsid. The nucleocapsid acts as a scaffold for genome condensation and as a template for RNA replication and transcription. Conformational changes in the MuV nucleocapsid are required to switch between different activities, but the underlying mechanism remains elusive due to the absence of high-resolution structures. Here, we report two MuV nucleoprotein-RNA rings with 13 and 14 protomers, one stacked-ring filament and two nucleocapsids with distinct helical pitches, in dense and hyperdense states, at near-atomic resolutions using cryo-electron microscopy. Structural analysis of these in vitro assemblies indicates that the C-terminal tail of MuV nucleoprotein likely regulates the assembly of helical nucleocapsids, and the C-terminal arm may be relevant for the transition between the dense and hyperdense states of helical nucleocapsids. Our results provide the molecular mechanism for structural plasticity among different MuV nucleocapsids and create a possible link between structural plasticity and genome condensation.
Magnetic helicity and energy budget around large confined and eruptive solar flares
Authors: Gupta M. , Thalmann J. K. , Veronig A. M. 
Published: July 2021

Context. In order to better understand the underlying processes and prerequisites for solar activity, it is essential to study the time evolution of the coronal magnetic field of solar active regions (ARs) associated with flare activity.
Aims. We investigate the coronal magnetic energy and helicity budgets of ten solar ARs around the times of large flares. In particular, we are interested in a possible relation of the derived quantities to the particular type of the flares that the AR produces, namely, whether they are associated with a CME or whether they are confined (i.e., not accompanied by a CME).
Methods. Using an optimization approach, we employed time series of 3D nonlinear force-free magnetic field models of ten ARs, covering a time span of several hours around the time of occurrence of large solar flares (GOES class M1.0 and larger). We subsequently computed the 3D magnetic vector potentials associated to the model 3D coronal magnetic field using a finite-volume method. This allows us to correspondingly compute the coronal magnetic energy and helicity budgets, as well as related (intensive) quantities such as the relative contribution of free magnetic energy, EF/E (energy ratio), the fraction of non-potential (current-carrying) helicity, |HJ|/|HV| (helicity ratio), and the normalized current-carrying helicity, |HJ|/ϕ′2.
Results. The total energy and helicity budgets of flare-productive ARs (extensive parameters) cover a broad range of magnitudes, with no obvious relation to the eruptive potential of the individual ARs, that is, whether or not a CME is produced in association with the flare. The intensive eruptivity proxies, EF/E and |HJ|/|HV|, and |HJ|/ϕ′2, however, seem to be distinctly different for ARs that produce CME-associated large flares compared to those which produce confined flares. For the majority of ARs in our sample, we are able to identify characteristic pre-flare magnitudes of the intensive quantities that are clearly associated with subsequent CME-productivity.
Conclusions. If the corona of an AR exhibits characteristic values of ⟨|HJ|/|HV|⟩ > 0.1, ⟨EF/E⟩ > 0.2, and ⟨|HJ|/ϕ′2⟩ > 0.005, then the AR is likely to produce large CME-associated flares. Conversely, confined large flares tend to originate from ARs that exhibit coronal values of ⟨|HJ|/|HV|⟩ ≲ 0.1, ⟨EF/E⟩ ≲ 0.1, and ⟨|HJ|/ϕ′2⟩ ≲ 0.002.
Uncovering the ultimate planet impostor
Authors: Lillo-Box J. , Ribas Á. , Montesinos B. , Santos N. C. , Campante T. , Cunha M. , Barrado D. , Villaver E. , Sousa S. , Bouy H. , Aller A. , Corsaro E. , Li T. , Ong J. M. J. , Rebollido I. , Audenaert J. , Pereira F. 
Published: July 2021

Context. Exoplanet searches through space-based photometric time series have shown to be very efficient in recent years. However, follow-up efforts on the detected planet candidates have been demonstrated to be critical to uncover the true nature of the transiting objects.
Aims. In this paper we show a detailed analysis of one of those false positives hidden as planetary signals. In this case, the candidate KOI-3886.01 showed clear evidence of a planetary nature from various techniques. Indeed, the properties of the fake planet set it among the most interesting and promising for the study of planetary evolution as the star leaves the main sequence.
Methods. To unveil the true nature of this system, we present a complete set of observational techniques including high-spatial resolution imaging, high-precision photometric time series (showing eclipses, phase curve variations, and asteroseismology signals), high-resolution spectroscopy, and derived radial velocities to unveil the true nature of this planet candidate.
Results. We find that KOI-3886.01 is an interesting false positive case: a hierarchical triple system composed by a ~K2 III giant star (KOI-3886 A) accompanied by a close-in eclipsing binary formed by a subgiant ~G4 IV star (KOI-3886 B) and a brown dwarf (KOI-3886 C). In particular, KOI-3886 C is one of the most irradiated brown dwarfs known to date, showing the largest radius in this substellar regime. It is also the first eclipsing brown dwarf known around an evolved star.
Conclusions. In this paper we highlight the relevance of complete sets of follow-up observations to extrasolar planets detected by the transit technique using large-pixel photometers such as Kepler and TESS and, in the future, PLATO. In particular, multi-color high-spatial resolution imaging was the first hint toward ruling out the planet scenario in this system.
Effects of linaclotide in the treatment of chronic constipation and irritable bowel syndrome with constipation: a meta-analysis
Authors: Zhao Qi , Fang Yongkun , Yan Cheng , Gao Jing , Liu Zhuangzhuang , Zhu Hanjian , Tang Dong , Wang Daorong 
Published: July 2021

Abstract
Objective Linaclotide is a guanylate cyclase-C (GCC) agonist that is found in intestinal epithelial cells and is used when treating chronic constipation (CC) and irritable bowel syndrome with constipation (IBS-C). Several randomized controlled trials (RCTs) were conducted for evaluating its efficacy and safety.
Methods The PubMed, EMBASE, and Cochrane databases and the Web of Science were searched to find multiple RCTs of patients with CC or IBS-C. The Jadad scoring system was used for evaluating each study’s methodological quality, and RevMan5.3 was used for meta-analysis. The composite endpoint reaction approved by the FDA, abdominal pain and discomfort relief, symptom improvement, and diarrhea-related adverse reactions were chosen as observation indicators, and relative risk (RR) and 95% confidence interval (CI) were obtained for quantitative and comprehensive evaluation.
Results Eleven randomized controlled studies were included, consisting of 5 cases of CC and 6 cases of IBS-C. Linaclotide reached the composite endpoint response approved by FDA in the treatment of CC (RR = 3.26, 95% CI: 2.45–4.33), and the composite endpoint response approved by FDA for the treatment of IBS-C (RR = 2.26, 95% CI: 1.86–2.74) was greater than the placebo (both p < 0.00001). The main adverse reactions of linaclotide were gastrointestinal, mostly diarrhea, which was higher than that of the placebo when treating CC (RR = 3.56, 95% CI: 2.76–4.60) and IBS-C (RR = 8.23, 95% CI: 5.69–11.90) (both p < 0.00001).
Conclusion Linaclotide proved to be effective and safe for the treatment of CC and IBS-C compared to the placebo. However, diarrhea is the primary adverse reaction.
Successful Homoeopathic Treatment of Phyllodes Tumour: A Case Study
Authors: Shukla Purnima , Misra Purak , Jain Risabh Kumar , Misra Rajiv Kumar 
Published: July 2021

AbstractPhyllodes tumours (PTs) of the breast are rare biphasic fibroepithelial neoplasm. They have potentiality to recur and metastasise. Majority of them follow a benign clinical course. We have treated one patient suffering from PT at the out-patient department of Sri Ram Medical & Homoeopathic Research Centre, Gorakhpur, India. After detailed case taking and repertorisation, first Conium maculatum and later on Phytolacca decandra and Calcarea fluorica were prescribed on the basis of individualisation to treat the case. Outcomes were assessed clinically every month for subjective improvement and objectively by ultrasonography reports at every 6-month interval. Gradual improvement was noted over time. The case has been assessed with MONARCH Inventory, which shows ‘definite’ association between the medicine and the outcome.
Uncovering Membrane-Bound Models of Coagulation Factors by Combined Experimental and Computational Approaches
Authors: Ohkubo Y. Zenmei , Madsen Jesper J. 
Published: July 2021

AbstractIn the life sciences, including hemostasis and thrombosis, methods of structural biology have become indispensable tools for shedding light on underlying mechanisms that govern complex biological processes. Advancements of the relatively young field of computational biology have matured to a point where it is increasingly recognized as trustworthy and useful, in part due to their high space–time resolution that is unparalleled by most experimental techniques to date. In concert with biochemical and biophysical approaches, computational studies have therefore proven time and again in recent years to be key assets in building or suggesting structural models for membrane-bound forms of coagulation factors and their supramolecular complexes on membrane surfaces where they are activated. Such endeavors and the proposed models arising from them are of fundamental importance in describing and understanding the molecular basis of hemostasis under both health and disease conditions. We summarize the body of work done in this important area of research to drive forward both experimental and computational studies toward new discoveries and potential future therapeutic strategies.
Fenton Syndrome: Diagnosis and Treatment with 3D-Printed Models. An Unusual Case Report
Authors: Sánchez José Luis Muñoz , Carrasco Vladimir Jorge , Ribot Pedro Zorrilla 
Published: July 2021

AbstractScaphocapitate syndrome, also called Fenton syndrome, is a rare, complex condition. Since it is often missed on initial evaluation, it is a diagnostic challenge. A high index of suspicion is required for early surgical treatment, avoiding future palliative surgery or sequelae. Cutting-edge diagnostic technologies, including three-dimensional printed models, are becoming essential tools, enabling the treatment of complex trans-scaphocapitate fracture-dislocations using open reduction and internal fixation with screws, with excellent outcomes at a 12-month follow-up period.
Surgical Anatomy of the Medial Antebrachial Cutaneous Nerve: Clinical Application in Ulnar Nerve Decompression Surgery in the Elbow
Authors: Gomez-Eslava Barbara , García-González Luis Alejandro 
Published: July 2021

Abstract
Introduction Lesion to the posterior branch of the medial antebrachial cutaneous nerve (MACN) is one of the causes of revision of the ulnar nerve decompression surgery in the elbow.To avoid the morbidity associated with this injury, cadaver dissections were performed to identify this branch in its course through the ulnar tunnel.
Methods We included 20 upper extremities of fresh cadaveric specimens. The posterior branch of the MACN was identified proximal to medial epicondyle and followed past the ulnar tunnel. The number of ramifications and their coordinates were recorded in a Cartesian plane, with the medial epicondyle as the central point.
Results The posterior branch passed proximal and posterior to the medial epicondyle in all specimens, except one. The average of the adjusted x value is of 30 mm, and of the adjusted y value is -18 mm. Additionally, we determined that the posterior branch passes at an average angle of 30° with respect to the x axis.
Conclusion The anatomical descriptions of this branch focused on surgical release of the ulnar nerve in the elbow are limited, and measures are only described in the horizontal plane (from proximal to distal). Schematizing the anatomy of this branch in its course throughout the ulnar tunnel will facilitate its identification during the procedures. However, variability and asymmetry in the branching pattern should be considered.
Arthroscopic Management of Intra-articular Ligament Lesions on Distal Radius Fractures
Authors: Aita Marcio Aurelio , Kaempf Ricardo , Biondi Bruno Gianordoli , Montano Gary Alan , Towata Fernando , Rodriguez Gustavo Luis Gomez , Ruggiero Gustavo Mantovani 
Published: July 2021

AbstractArticular distal radius fractures (DRFs) have increased in incidence in recent years, especially among the economically active population. Most of the treatment approaches are based on plain X- rays, and do not give us any information on how to treat these fractures. In the search for solutions with greater precision in diagnosis, in reducing the joint surface of the fracture, and envolving minimally-invasive techniques, we found arthroscopy as the main tool for these patients. Therefore, an enhanced understanding of the biomechanics of the different types of fracture associated with ligamentous lesions should facilitate the right decision regarding the treatment. The present paper aims at providing a management-oriented concept to diagnose and treat ligamentous lesions associated with intra-articular DRFs based on a arthroscopy-assisted procedure, and showing the objective and patient-reported outcomes and a new classification. The objective and patient-reported outcomes were: the mean range of motion (ROM) was of 94.80% on the non-affected side; the mean score on the abbreviated version of the Disabilities of the Arm, Shoulder and Hand questionnaire (QuickDASH) was of 3.6 (range: 1 to 12). The score on the Visual Analog Scale (VAS) was of 1.66 (range: 1 to 3). Complications were observed in 2 (13.33%) patients: extensor tendon synovitis in 1 patient, and a limitation (stiffness) in ROM in 1 patient, both treated with wrist arthroscopy release. The mean time until the return to work was of 6.4 weeks. In patients with unstable intra-articular DRFs associated with ligamentous lesions, the fixation of specific osseous-ligamentous fragments and ligamentous repair/reconstruction by wrist arthroscopy prove to be a safe and reliable treatment. The clinical and functional results predict that the patients can return to work more quickly.
Endothelial Progenitor Cells Modulate the Phenotype of Smooth Muscle Cells and Increase Their Neointimal Accumulation Following Vascular Injury
Authors: Mause Sebastian F. , Ritzel Elisabeth , Deck Annika , Vogt Felix , Liehn Elisa A. 
Published: July 2021

Abstract
Background Smooth muscle cells (SMCs) are the main driver of neointima formation and restenosis following vascular injury. In animal models, endothelial progenitor cells (EPCs) accelerate endothelial regeneration and reduce neointima formation after arterial injury; however, EPC-capture stents do not reduce target vessel failure compared with conventional stents. Here we examined the influence of EPCs on features of SMCs pivotal for their impact on injury-induced neointima formation including proliferation, migration, and phenotype switch.
Methods and Results EPCs, their conditioned medium, and EPC-derived microparticles induced proliferation of SMCs while limiting their apoptosis. In transwell membrane experiments and scratch assays, EPCs stimulated migration of SMCs and accelerated their recovery from scratch-induced injury. Treatment of SMCs with an EPC-derived conditioned medium or microparticles triggered transformation of SMCs toward a synthetic phenotype. However, co-cultivation of EPCs and SMCs enabling direct cell–cell contacts preserved their original phenotype and protected from the transformative effect of SMC cholesterol loading. Adhesion of EPCs to SMCs was stimulated by SMC injury and reduced by blocking CXCR2 and CCR5. Interaction of EPCs with SMCs modulated their secretory products and synergistically increased the release of selected chemokines. Following carotid wire injury in athymic mice, injection of EPCs resulted not only in reduced neointima formation but also in altered cellular composition of the neointima with augmented accumulation of SMCs.
Conclusion EPCs stimulate proliferation and migration of SMCs and increase their neointimal accumulation following vascular injury. Furthermore, EPCs context-dependently modify the SMC phenotype with protection from the transformative effect of cholesterol when a direct cell–cell contact is established.
Demographic and Clinical Profile of Psychiatry Patients of Rural Homoeopathic Hospital, Palghar, Maharashtra, India, from 2014 to 2018
Authors: Nikumbh Sunita , Kukde Abhishek , Patel Manoj , Parekh Bhavik , Nigwekar Anoop , Mittal Renu , Dhawale Kumar 
Published: July 2021

Abstract
Background Rural Homoeopathic Hospital has been serving the community in and around Palghar for the past 20 years. Through a Central Government Scheme of Centre of Excellence, it received funds for setting up an inpatient psychiatric unit in 2012 whereby it could serve the wider community by admitting the patients with mental illness in a secure ward. This is the first part of two papers which deals with demographic analysis of the patients admitted in the psychiatry ward between 2014 and 2018.
Objectives The case records were studied with a view to determine the demographic features, the clinical diagnosis and the duration of stay.
Methodology All case records were studied as per a predetermined format to establish the demographic features, the clinical diagnosis and the duration of stay in the ward.
Results Out of 1,015 patients seen, 35% were having alcohol withdrawal, 12.7% were having conversion, 9.8% were having suicidal attempt and 9.7% were suffering from anxiety. The duration of stay in the hospital was noticeably shorter than what has been reported from the allopathic admissions.
Conclusion Alcoholism followed by conversion disorders, suicidal attempts and anxiety-panic conditions was the most common psychiatric condition with which patients were admitted. Males were predominating mainly due to their alcoholic condition. The duration of stay was reasonably short. The reasons for this would need further exploration.
Gallium doped zinc oxide thin films as transparent conducting oxide for thin-film heaters
Authors: Beckford Jasmine , Behera Makhes K. , Yarbrough Kelsea , Obasogie Brandon , Pradhan Sangram K. , Bahoura Messaoud 
Published: July 2021

The addition of suitable metallic dopants into the indium or zinc oxide matrix is essential to obtain transparent conducting oxide (TCO) thin films for high-performance optoelectronics devices. However, scarcity of indium is one of the major challenges for the common use of indium doped tin oxide (ITO) as a TCO material for future state-of-the-art devices. To overcome the challenge, doped zinc oxide is used an alternative material for traditional ITO and retains both high transparency and electrical conductivity. One such potential material is gallium-doped zinc oxide (GZO). GZO thin films were deposited onto glass as well as Kapton substrates using the pulsed laser deposition technique. Structural, optical, and electro-thermal properties of these films were studied to assess the performance of the films as thin-film transparent heaters. The samples show a good transmittance value greater than 85% in the visible range of the electromagnetic spectrum. At room temperature, the electrical resistivity of GZO films showed a value of 110.46 × 10−4 Ω cm on glass and 2.90 × 10−4 Ω cm on the Kapton substrate, followed by a Joule heating effect, with temperatures reaching more than 120 °C at an applied voltage of ∼12 V. This high transparency, cost-effectiveness, low sheet resistance, and small surface roughness make GZO a unique and potential candidate for various practical applications not only as a transparent electrode but also as an indium free thin-film transparent heater and an affordable transparent conducting oxide in displays.
Nonequilibrium Kondo regime current noise spectrum of quantum dot systems with the single impurity Anderson model
Authors: Mao Hong , Jin Jinshuang , Wang Shikuan , Yan YiJing 
Published: July 2021

We investigate the nonequilibrium current noise spectrum of single impurity Anderson model quantum dot systems on the basis of the accurate dissipation equation of motion evaluations. By comparing between the equilibrium and nonequilibrium cases and between the non-Kondo and Kondo regimes, we identify the current noise spectrum of the nonequilibrium Kondo features that actually appear in the entire region of ω ∈ [−eV, eV]. It is well known that the primary Kondo characteristics at ω = ±eV = ±(μL − μR) display asymmetrical upturns and remarkable peaks in S(ω) and dS(ω)/dω, respectively. These features are originated from the Rabi interference of the transport current dynamics, with the Kondo oscillation frequency of |eV|. Moreover, we also identify the minor but very distinguishable inflections, crossing over from ω = −eV to ω = +eV. This uncovered feature would be related to the interference between two Kondo resonance channels.