bluuebunny/crossref_metadata_2025_split huggingface dataset:
Critical assessment of commercially available microtitre panels for antimicrobial susceptibility testing of veterinary pathogens
Authors: Schwarz Stefan , Bäumer Wolfgang , Feßler Andrea T , Jung Arne , Kaspar Heike , Kehrenberg Corinna , Richter Angelika , Schwarz Christine , Verspohl Jutta , Werckenthin Christiane 
Published: December 2024

Abstract
Antimicrobial susceptibility testing (AST) in the veterinary sector by broth microdilution is mainly based on commercially available microtitre plates with specific panels. A critical review of commercially available microtitre panels identified AST panels that fulfil the requirements for obtaining reliable AST results by covering the necessary antimicrobial concentrations for both clinical breakpoints as well as quality control (QC) ranges for approved QC strains. However, there are AST panels in which these prerequisites are only in part fulfilled, and some AST panels that do not fulfil the aforementioned criteria at all. Most customers believe that commercially available microtitre panels, which are used in microbiological diagnostic laboratories, reliably allow the identification of susceptible, intermediate or resistant bacteria in addition to sufficient QC ranges to validate the test system. Unfortunately, our findings revealed that this assumption is not always true, and thus it is time to reinforce the necessary requirements that microtitre panels must fulfil to give reliable AST data.
Lack of Association between Vitamin D Genetic Polymorphism and Virological Characteristics of Hepatitis B Infection
Authors: da Silva Jéssica C , Caetano Amanda R , Mendonça Ana C da F , Scalioni Leticia de P , Portilho Moyra M , Bezerra Cristianne S , Marques Vanessa A , Miguel Juliana C , Rodrigues Karis M P , Ivantes Cláudia A P , Lewis-Ximenez Lia L , Villar Livia M 
Published: December 2024

Abstract

Background
Exploring polymorphisms in vitamin D-related genes (VDR) within the Brazilian population provides a valuable model to contribute to the influence of the host genetic variants on chronic viral hepatitis B (CHB).

Methods
126 CHB patients were enrolled in the current study and clinical, laboratory, and 25-hydroxyvitamin D [25(OD)D] level data were obtained. Four VDR (rs7975232, rs1544410, rs10735810, rs731236) and 2 vitamin D-binding protein/carrier globulin (GC) polymorphisms (rs4588 and rs7041) were determined using TaqMan assays and nucleotide sequencing. Association studies were conducted among viral infection parameters and the patient's genetic variants.

Results
Most patients were male (52.38%) with a mean age of 44.28 (±14.24) years, self-identified as White (32.54%), and exhibited vitamin D insufficiency status (42.06%). The hepatitis B virus (HBV) genotype A was predominant (50%) and 62.7% of the patients had detectable HBV DNA levels ≤log10 3 IU/mL. A significant association was observed between HBV genotype A with ApaI and FokI single nucleotide polymorphisms. However, no statistical association between VDR polymorphisms and viral load, viral polymerase mutations, or vitamin D status was found. Vitamin D concentration did not correlate to HBV viral load.

Conclusions
Most HBV-infected individuals presented vitamin D insufficiency, and VDR polymorphism was not associated with virological characteristics except with HBV genotype A, demonstrating that some human genetic signatures are related to HBV genotype distribution.
CMLsearch: Semantic visual search and simulation through segmented colour, material, and lighting in interior image
Authors: Jin Semin , Choi Jiin , Hyun Kyung Hoon 
Published: December 2024

Abstract
In product search systems, user behaviour changes according to their intentions, requiring adaptations in system requirements and information modelling. When purchasing home decor products, users must consider their existing home setting (EHS) and the need to pair multiple elements, not just a single product. However, no existing home decor search systems assist with varied search intents (target-finding and decision-making scenarios), nor have they focused on research that helps pair various elements of a user's EHS. Therefore, we introduce CMLsearch: a semantic visual search system that segments Colour, Material, and Lighting (CML), and includes light correlated colour temperature (CCT) simulation. In a user study (N = 44), CMLsearch significantly improved user satisfaction and purchasing decisions compared with conventional systems. The semantic visual search reflected user intent, offering object-level control that supported more focused searches in target-finding scenarios and broader exploration in decision-making scenarios. The light CCT simulation further boosted confidence by allowing users to visualize the products under different lighting conditions.
Business politics as a causal mechanism shaping uneven regional development across Romania’s automotive industry
Authors: Jipa-Muşat Ioana , Campling Liam , Prevezer Martha 
Published: December 2024

Abstract
We develop and deploy a business politics lens to examine the mechanisms and processes of negotiation through which multinational enterprises (MNEs) and various host country actors interact, leading to different regional trajectories of economic development. We assess two contrasting lead firms from differing home country contexts investing in the automotive industry in Romania, operating in two regions with distinct historical-spatial industrial organization and economic development. We advance a contribution on business politics as dynamic, relational, multi-scalar, and influenced by varied conjunctural factors—historical, geographical, political, institutional, and firm-driven—exposing how MNEs and territorial actors co-shape distinct processes of international economic (dis)integration.
Reservoir characterization: how broadband wide-azimuth and high-density seismic can help
Authors: Zhang Shaohua , Song Qianggong 
Published: December 2024

Abstract
This paper discusses how broadband wide-azimuth and high-density seismic exploration has been used to characterize deep-buried hydrocarbon reservoirs as well as fractured carbonate and tight sandstone reservoirs in complex areas. Deeply buried hydrocarbon reservoirs with complex structures can be delineated with improved seismic imaging results due to improved fold, azimuth, and offset coverage; fractured carbonate and tight sandstone reservoirs often exhibit strong anisotropy with fractures being the major fluid pathways, and examination of the resultant azimuthal changes in P-wave attributes can provide us with a better definition of their internal structures. In addition, the improved frequency bandwidth of broadband seismic data can provide us with higher seismic resolution than conventional data and better characterization of reservoir heterogeneity, such as lateral variations of sand channels and small slip fault systems. Current practice and various examples have shown that broadband wide-azimuth and high-density three-dimensional (3D) seismic exploration is the undoubted leading-edge tool for exploring the remaining oil in complex reservoirs, and it plays a crucial role in improving reserve growth and hydrocarbon recovery, to meet the ever-increasing energy demand worldwide.
High order shallow water equations: application to dam break problems
Authors: Ndengna Ngatcha Arno Roland 
Published: December 2024

Abstract
The majority of shallow flows that occur in sediment transport are turbulent, and as a result, cannot be described by shallow water equations. This paper introduces a set of shallow water equations based on the long-wave second-order approximation. The set of equations is employed in the modeling of sediment transport in coastal zones, thereby facilitating the consideration of a diverse array of civil engineering problems. The derived sediment transport model is capable of representing the coupling of sediment transport phenomena with turbulent flow in shallow regions. The proposed models utilize the concept of two-velocity vectors (comprising a mean velocity and a distortion velocity due to turbulence) in the primary flow directions. To demonstrate the efficacy of the model, a numerical scheme is employed to solve a number of dam-break problems that are well-known in the field.
The Effect of Nirmatrelvir-Ritonavir on Short- and Long-term Adverse Outcomes From COVID-19 Among Patients With Kidney Disease: A Propensity Score–Matched Study
Authors: Strohbehn Ian A , Ouyang Tianqi , Lee Meghan D , Zhao Sophia , Harden Destiny , Mejia Sherley M , Cao Andrew , Bhattacharyya Roby P , Sise Meghan E 
Published: December 2024

Abstract

Background
Patients with kidney disease are at high risk for adverse outcomes after coronavirus disease 2019 (COVID-19) despite vaccination. Because patients with advanced chronic kidney disease (CKD) and kidney failure were excluded from registrational trials, the impact of the protease inhibitor nirmatrelvir-ritonavir in patients with kidney disease is unknown.

Methods
This was a cohort study evaluating adverse outcomes in patients with kidney disease who developed COVID-19. Patients prescribed nirmatrelvir-ritonavir for COVID-19 between March 16, 2022, and November 30, 2022, were propensity score–matched to comparators diagnosed with COVID-19 between July 15, 2021, and March 15, 2022 (before the use of nirmatrelvir-ritonavir in our health care network). We determined the association between nirmatrelvir-ritonavir and short- and long-term outcomes using Fine-Gray subdistribution hazard and Cox proportional hazard models, adjusting for potential confounders. Outcomes included 30-day risk of hospitalization and 1-year risk of a major adverse cardiovascular event (MACE), CKD progression, and death.

Results
A total of 1095 nirmatrelvir-ritonavir-treated patients were matched to 584 comparators. Patients who received nirmatrelvir-ritonavir patients were less likely to be hospitalized within 30 days of diagnosis (adjusted subdistribution hazard ratio [sHR], 0.44; 95% CI, 0.26–0.73; P &lt; .01). At 1 year, nirmatrelvir-ritonavir-treated patients had a lower risk of hospitalization for MACE (adjusted sHR, 0.49; 95% CI, 0.36–0.67; P &lt; .01) and death (adjusted hazard ratio, 0.37; 95% CI, 0.21–0.65; P &lt; .01). Use of nirmatrelvir-ritonavir was not associated with decreased risk of CKD progression or attenuation of estimated glomerular filtration rate decline slope in the year following infection.

Conclusions
Nirmatrelvir-ritonavir was associated with decreased risk of hospitalization within 30 days and 1-year risk of MACE and death in patients with CKD and kidney failure.
The concepts of irreversibility and reversibility in research on anthropogenic environmental changes
Authors: Buhr Lorina , Lenzi Dominic S , Pols Auke J K , Brunner Claudia E , Fischer Andrea , Staal Arie , Hofbauer Benjamin P , Bovenkerk Bernice 
Published: December 2024

Abstract
The concept of “irreversibility” and its counterpart “reversibility” have become prominent in environmental and ecological research on human-induced changes, thresholds, climate tipping points, ecosystem degradation, and losses in the cryosphere and biosphere. Through a systematic literature review, we show that in these research fields, these notions are not only descriptive terms, but can have different semantic functions and normative aspects. The results suggest that, in the context of environmental and ecological research the concepts of irreversibility and reversibility have taken on additional usages in comparison to their contexts in theoretical thermodynamics and mechanics. Irreversible as a classification of anthropogenic environmental change can be used categorically, in the sense of a finite end, or relatively, i.e. on time or spatial scales of interest. Surprisingly, most of the analyzed scientific articles that use the terminology of (ir)reversibility substantively do not provide an explicit conceptualization or definition (74.7%). The research on potential (ir)reversibility of environmental change may affect the social and political willingness to bear the costs of interventions to mitigate or prevent undesirable environmental change. In particular, classifying a change as reversible or irreversible and determining the timescale(s) and spatial scale(s) involved has implications for policy and ecosystem management decisions, as suggested by its use in several high-level scientific and policy reports on ecosystem and climate change. Therefore, it is important to explicitly present a clear definition of irreversibility or reversibility for the readers from other fields, even if it could be the case that within a specific community an implicit definition was considered to be sufficient. We propose further recommendations for inter- and transdisciplinary reflection and conceptual use in the context of environmental, ecological, and sustainability research.
Collegial Virtues and Vises
Authors: Hume Robert J 
Published: December 2024

Abstract
This review essay of The Elevator Effect, by Morgan L. W. Hazelton, Rachael K. Hinkle, and Michael J. Nelson, considers the authors' premise that collegiality is a central determinant of judicial behavior, on par with other leading influences such as attitudes, the law, and strategy. The authors make a strong case that judges on collegial courts forge relationships when they serve in close contact with one another over long careers and that these relationships influence the choices judges make. This review essay engages the authors' theory and highlights the areas in which it seems to offer the most explanatory power: notably, the decision by judges to write separately (e.g., dissent, concur) on the U.S. Courts of Appeals. The essay also reflects on the limitations of collegiality and how the theory may be less helpful in accounting for behavior in other contexts, such as the U.S. Supreme Court. Among the topics explored are the decision to reverse, citation practices, and the use of discourteous rhetoric by federal judges.
Use of Practices to Reduce of Sudden Unexpected Infant Death among Caregivers of Opioid Exposed Newborns
Authors: Parker Margaret G. , Rice Fiona , Peguero Chanel , Evans Ariana , Schiff Davida M. , Colvin Bryanne , Friedman Hayley , Harer Katherine , Kerr Stephen M. , Corwin Michael J. , Heeren Timothy C. , Colson Eve R. , Wachman Elisha M. 
Published: December 2024

Objectives
Sudden unexpected infant death (SUID) occurs disproportionately among opioid exposed newborns (OENs) compared to those unexposed. The extent that primary caregivers of OENs adhere to SUID-reducing infant care practices is unknown. We examined rates of SUID-reducing practices (smoking cessation, breastfeeding, and safe sleep [supine sleep, room-sharing not bed-sharing, nonuse of soft bedding or objects]) in a pilot sample of caregivers of OENs.

Methods
We surveyed 50 English-speaking mothers and other primary caregivers of OENs 1–6 months old between 02/2022 and 10/2023. We examined prenatal and postnatal cigarette smoking exposure, breastfeeding initiation and duration, and sleep position (side, back, or stomach), sleep location (bed-sharing, room-sharing not bed-sharing, or separate room), and soft bedding or objects in the infant sleep space.

Results
Thirty-six (72%) of 50 respondents were birth mothers and 14/50 (28%) were other caregivers. Sixty-one percent of infants were exposed to cigarette smoking prenatally (mothers only) and 34% postnatally (41% mothers vs 14% other caregivers). Sixty percent of infants received breast milk ≤4 weeks. Among respondents, 32% placed infants in nonsupine sleep position (36% mothers vs 21% other caregivers), 38% shared a bed with their infant for sleep (47% mothers vs 14% other caregivers), and 30% used soft bedding in the infant sleep space (33% among mothers vs 21% among other caregivers).

Conclusions
Infant care practices associated with SUID were highly prevalent in our pilot sample of OENs and differed among mothers versus other caregivers. Further investigation and tailored approaches to this population are needed.
Direct Immunofluorescence in Dermatomyositis and Lupus Erythematosus: Cross-Sectional Diagnostic Accuracy and Correlation With Serologies and Other Features of Systemic Disease
Authors: Jacobson Rebecca , Kazmi Maha , Vaughan Heidi , Agnihothri Ritesh , North Jeffrey P. , Connolly M. Kari , Haemel Anna 
Published: December 2024

Abstract:
This is a retrospective cross-sectional diagnostic test accuracy study of direct immunofluorescence (DIF) performed on a group of potential lupus erythematosus (LE)/dermatomyositis (DM) skin biopsies from 2015 to 2020 at a large, academic medical center. For purposes of this study, which was focused primarily on detection of LE/DM-related interface dermatitis, DIF was considered positive for a LE/DM pattern if it showed granular deposition of immunoglobulin G, with or without C3, at the basement membrane zone on the final pathology report. Blinded clinicopathologic correlation was the reference standard. One thousand fifty-eight sequential pairs of skin biopsies obtained from adults and submitted for both DIF and routine histology were screened. Cases were excluded if histopathology did not demonstrate features that could be consistent with LE/DM (broadly predefined as interface dermatitis and/or neutrophilic dermatosis), resulting in 254 cases of possible LE/DM eruptions for further analysis. Sensitivity of DIF with an immunoglobulin G granular pattern at the basement membrane zone was 71.4% (confidence interval 55.4%–84.3%) in LE-related and 59.3% (confidence interval 38.8%–77.6%) in DM-related eruptions. No statistically significant difference was found in sensitivities of DIF between LE and DM (P = 0.3). DIF positivity did not correlate with available key demographic, clinical, and serologic features.
Intramuscular Cellular Nodules in a Congenital Large Plaque-Like Blue Nevus: Melanoma or Not?
Authors: Tirumalae Rajalakshmi , Correa Marjorie , Manjunath Suraj 
Published: December 2024

Introduction:
Melanoma arising in blue nevus (BN) is usually evident on histopathology. However, there are cases in the gray zone where neither morphology nor immunostains and molecular studies are conclusive.

Case Report:
A 33-year-old man presented with greenish discoloration of the abdominal skin at birth. Over time, the lesion increased in size to involve the entire left half of the abdomen, extending to the back and chest wall. He noticed nodules beneath the lesion, which were enlarging. Magentic resonanace imaging showed a lesion within the left external oblique measuring 8.3 × 6 × 4 cm and smaller lesions in the adjacent muscular planes. Gross examination of the excision showed an 8 × 6.5 × 5 cm brown-black, intramuscular nodule. Histopathology showed a BN of the overlying skin extending into the subcutis. The intramuscular nodule showed infiltrative, cellular areas with nonpigmented, plump spindle cells in nests and pseudorosettes with focal necrosis. There was minimal pleomorphism and prominent eosinophilic nucleoli. Mitoses were scarce. The neoplastic cells expressed Melan A, S100, and HMB45 with a low proliferative index (<1%). The lack of atypia and mitoses, despite clinically suspicious for melanoma, lead us to perform comparative genomic hybridization, which showed an abnormality suggesting malignancy. The patient remains with localized disease 6 years after surgery and no distant metastases.

Conclusions:
Cellular nodules in a plaque-like blue nevus presenting as an intramuscular mass is hitherto unreported. It is prudent to follow-up such cases like a melanoma, despite lacking overt atypia and mutations, because metastases have been reported as late as 16 years after diagnosis.
Association of Early-life Trauma With Gestational Diabetes and Hypertensive Disorders of Pregnancy
Authors: Lovett Sharonda M. , Woo Jennifer M. P. , O’Brien Katie M. , Parker Samantha E. , Sandler Dale P. 
Published: December 2024

Background:
Early-life trauma (before age of 18 years) is hypothesized to increase the risk for adverse pregnancy outcomes through stress pathways, yet epidemiologic findings are mixed.

Methods:
Sister Study participants (US women aged 35–74 years enrolled 2003–2009) completed an adapted Brief Betrayal Trauma Survey at the first follow-up visit. Lifetime history of gestational diabetes mellitus (GDM) or hypertensive disorders of pregnancy (HDP: pregnancy-related high blood pressure, pre-eclampsia/toxemia, or eclampsia) in pregnancies lasting ≥20 weeks was self-reported. We used log–binomial regression to estimate relative risks (RR) and 95% confidence intervals (CIs) for the association between early-life trauma (modeled using conventional measures [e.g., any experience, substantive domains, individual types] and latent classes of co-occurring traumas) and GDM or HDP among 34,879 parous women.

Results:
Approximately, 4% of participants reported GDM and 11% reported HDP. Relative to no early-life trauma, the RRs for any were 1.1 (95% CI = 1.0, 1.3) for GDM and 1.2 (95% CI = 1.2, 1.3) for HDP. Women reporting physical trauma had the highest risk of GDM and HDP in comparison to other substantive domains. In analyses using latent classes of early-life trauma, high trauma was associated with an elevated risk of both GDM (RR = 1.9, 95% CI = 1.5, 2.6) and HDP (RR = 1.7, 95% CI = 1.4, 2.0) compared with low trauma.

Conclusions:
Women experiencing high levels of trauma in early life were at higher risk of GDM and HDP, adding to a growing evidence base for this association.
Associations of Traumatic Brain Injury and Hearing: Results From the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)
Authors: Schneider Andrea L.C. , Kamath Vidyulata , Reed Nicholas S. , Mosley Thomas , Gottesman Rebecca F. , Sharrett A. Richey , Lin Frank R. , Deal Jennifer A. 
Published: December 2024

Objective:
To examine associations of traumatic brain injury (TBI) with self-reported and clinical measures of hearing function.

Setting:
Four US communities.

Participants:
A total of 3176 Atherosclerosis Risk in Communities Study participants who attended the sixth study visit in 2016-2017, when hearing was assessed.

Design:
Prospective cohort study. TBI occurring prior to the hearing assessment was defined using self-reported questions and “International Classification of Diseases-9th/10th Edition” (ICD-9/10) codes.

Main Measures:
Hearing function was assessed by self-reported questionnaires and clinically measured indices (audiometry [4-frequency pure tone average for each ear] and speech-in-noise testing). Linear, logistic, and multinomial logistic models adjusted for sociodemographics, vascular risk factors, and occupational noise exposure were used to examine associations.

Results:
Participants were a mean age of 79 years, 59% were female, 21% were of self-reported Black race, and 33% had a history of TBI (median time from first TBI to hearing assessment: 39 years (25th-75th percentile = 19-63 years). Compared to participants without TBI, participants with prior TBI had higher age-adjusted prevalence of self-reported hearing loss (42.3% vs 35.3%), tinnitus (28.0% vs 23.8%), hearing aid use (23.4% vs 17.8%), pure tone average > 40 dB (30.6% vs 24.8%), and presence in the lowest quartile of speech-in-noise performance (27.6% vs 22.8%). With further adjustment, and particularly with adjustment for occupational noise exposure, associations with hearing measures were largely no longer statistically significant. In secondary analyses of associations of TBI frequency and severity with hearing function, results were similar to our main analyses, without evidence of dose-dependent associations.

Conclusions and Relevance:
In this community-based cohort, prior TBI was associated with impaired hearing on both self-reported and clinically measured assessments, but these associations were attenuated after adjustment for occupational noise exposure. These results underscore the importance of the consideration of loud noise exposures, which may confound associations of TBI with hearing, in future studies.