bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality in validation from a Nordic perspective
Authors: Andersson Per 
Published: June 2021

AbstractQuality is a main issue when practices of validation are developed. In the Nordic countries, a model of quality assurance in validation has been introduced, to be applied in the development of validation practices. The model puts the individual at the centre and introduces eight factors for quality: information, preconditions, documentation, coordination, guidance, mapping, assessment, and follow‐up. This article presents and discusses the Nordic model as a tool for quality work in validation. In the discussion on the model, some more general concepts and perspectives on quality in validation are introduced, such as the call for a balance between flexibility and standardisation, and the need to understand quality in relation to the possible aims of the validation process. The article also applies the model to the analysis of a project for the development of validation work in cooperation between the municipalities in the region of East Sweden, in which the model appears to be useful for understanding and developing validation work.
The effects of climate, oceanography, and habitat on the distribution and abundance of northern California Current continental shelf groundfishes
Authors: Howard Rebecca A. , Ciannelli Lorenzo , Waldo Wakefield W. , Fewings Melanie R. 
Published: June 2021

AbstractThe California Current Ecosystem has experienced variable climate regimes, hypoxia, and marine heatwave events that have the potential to impact groundfishes and their associated fisheries. Using bottom trawl survey data collected by NOAA Fisheries, we assessed changes over the last four decades in northern California Current continental shelf (≤200 m) groundfish assemblage composition, species' presence, and relationships to environmental and habitat variables. We focus on the currently understudied continental shelf area, due to its ecological and economic importance, especially after the recent opening of historically important areas to trawling. We found a temporally consistent separation in groundfish assemblages between depth zones based on NMS analysis using species found in over 1% of samples, with shallow, mid‐, and deep shelf groupings. Grain size, species richness, and diversity were associated with assemblage composition. Then, focusing on petrale sole, rex sole, lingcod, arrowtooth flounder, sablefish, English sole, Pacific sanddab, and Dover sole, we examined what factors impact groundfish presence and abundance on the shelf. Bottom temperature, sediment characteristics, and depth were correlated with abundance for all species. These results corroborate previous work indicating recent reductions in presence of hypoxia‐intolerant species. Shallow‐water groundfishes known to tolerate warmer water and low dissolved oxygen concentrations exhibit reductions offshore, possibly a result of low recruitment. There have been significant spatiotemporal changes in the shelf groundfish populations over the past several decades, and while assemblage composition over most of the shelf remains consistent, single species distributional shifts may impact access to target species in newly reopened areas.
The impact of industrial structure upgrades on the urban–rural income gap: An empirical study based on China's provincial panel data
Authors: Zhou Qiuyang , Li Zhenqiang 
Published: June 2021

AbstractUsing panel data for 29 provinces in China from 2000 to 2018, this paper mainly presents an empirical study on the impact of industrial structure upgrades on the urban–rural income gap. An overall analysis at the national level is conducted before the separate analysis of the relevant content of China's eastern, central, and western regions. The results reveal that at the national level, the upgrading of industrial structure is conducive to narrowing the urban–rural income gap; however, the impact of industrial structure upgrades on the urban–rural income gap differs from different regions: in eastern China, the impact of industrial structure upgrades on the urban–rural income gap varies over time, and the relationship between the two variables shows an N‐shaped curve; in central China, the upgrading of industrial structure can help to narrow the income gap between urban and rural areas; in western China, upgrading the industrial structure will widen the urban–rural income gap. Finally, certain policy recommendations are proposed.
Breaking the mold: Working through our differences to vocalize the sound of change
Authors: Abdellatif Amal , Aldossari Maryam , Boncori Ilaria , Callahan Jamie , Na Ayudhya Uracha Chatrakul , Chaudhry Sara , Kivinen Nina , Sarah Liu Shan‐Jan , Utoft Ea Høg , Vershinina Natalia , Yarrow Emily , Pullen Alison 
Published: June 2021

AbstractThis paper orchestrates alterethnographical reflections in which we, women, polyphonically document, celebrate and vocalize the sound of change. This change is represented in Kamala Harris's appointment as the first woman, woman of color, and South Asian American as the US Vice President, breaking new boundaries of political leadership, and harvesting new gains for women in leadership and power more broadly. With feminist awareness and curiosity, we organize and mobilize individual texts into a multivocal paper as a way to write solidarity between women. Recognizing our intersectional differences, and power differentials inherent in our different positions in academic hierarchies, we unite to write about our collective concerns regarding gendered, racialised, classed social relations. Coming together across intersectional differences in a writing community has been a vehicle to speak, relate, share, and voice our feelings and thoughts to document this historic moment and build a momentum to fulfill our hopes for social change. As feminists, we accept our responsibility to make this history written, rather than manipulated or erased, by breaking the mold in the form of multi‐layered embodied texts to expand writing and doing research differently through re/writing otherness.
An Italian multicenter analysis of emergency admissions and treatment of upper tract urolithiasis during the lockdown and reopening phases of the COVID‐19 pandemic: Are we ready for a second wave of the outbreak?
Authors: Castellani Daniele , Ragonese Mauro , Di Rosa Mirko , Marzio Vittorio , Di Gianfrancesco Luca , Bassi Pierfrancesco , De Dominicis Mauro , Dellabella Marco , Antonucci Michele 
Published: June 2021

ObjectivesTo assess if the lockdown period (March–April 2020) during the coronavirus disease‐19 outbreak in Italy influenced the number, presentation, and treatment of urgent admissions to the emergency department for ureteral lithiasis, and to evaluate the same variables during the reopening phase (May–June 2020).MethodsWe performed a retrospective analysis of patients admitted to the emergency department of three different hospitals (two coronavirus disease‐19 hubs). Demographics and data on acute pyelonephritis, acute kidney injury, urinoma, hematuria, inpatient admission/discharge home, and type of treatment were gathered and compared with the same periods in 2019.ResultsA total of 516 patients were admitted during the study period, of whom 62.4% were male. Their mean age was 58.86 ± 16.24 years. The number of admissions decreased significantly, by 51.25% (P = 0.003), during lockdown compared to 2019 (78 vs 160 admissions). The number of admissions in the reopening phase (May–June 2020) was in line with that in 2019 (n = 138). The number of hospitalizations (P = 0.005), acute obstructive pyelonephritis (P = 0.019), and complications (P = 0.02) was statistically significantly higher during lockdown compared to 2019. The increase in the rate of surgical procedures nearly reached significance (P = 0.059). The odds of having complications and being hospitalized were almost fivefold (odds ratio 4.68, 95% confidence interval 1.98–11.07) and twofold greater (odds ratio 2.39, 95% confidence interval 1.29–4.43) compared to the same period in 2019. No difference was noted between May–June 2020 and 2019.ConclusionThe coronavirus disease‐19 lockdown period provoked a meaningful reduction in symptomatic ureteral lithiasis admission. Most patients presented with complicated disease, which required an increased rate of interventional procedures compared to the equivalent period in 2019. Admissions reverted to normal levels during the reopening phase.
Mapping the diversity and structuring of migration patterns: One‐off, repeat and multiple migrants in the European Union
Authors: Salamońska Justyna , Czeranowska Olga 
Published: June 2021

AbstractMuch migration research analyses one‐off migration from origin to destination, of a more‐or‐less permanent character. This paper argues that the reality of international movements is more complex. Thus, the aim of our analysis is to shed light on the diversity of migration patterns involving repeat movements between origin and destination and multiple migration, which encompass more than one destination country within its migration trajectory. A review of the literature points to the gap between the literature on repeat migration and that on multiple migration. These two strands of literature developed separately; each took as a frame of reference one‐off migration. In this paper we bridge this theoretical gap. Empirical analysis, based on the European Internal Movers’ Social Survey (EIMSS), quantifies the volume of one‐off, repeat and multiple movements between selected European Union countries. The study also points to how the diverse patterns of migration are socially structured.
Room‐temperature multiferroic characteristics and unique vortex domain structures of h‐Yb1−xInxFeO3 solid solutions
Authors: Liu Mei Ying , Sun Tu Lai , Zhu Xiao Li , Liu Xiao Qiang , Tian He , Chen Xiang Ming 
Published: June 2021

AbstractHexagonal rare‐earth ferrites (h‐RFeO3) have attracted much scientific attention due to their room‐temperature multiferroicity. However, it is still a hard job to obtain h‐RFeO3 bulk materials because of the meta‐stability of such hexagonal phase, and the evaluation of room‐temperature ferroelectric and magnetoelectric characteristics in such materials is also a challengeable issue. In the present work, Yb1−xInxFeO3 ceramics with the stable hexagonal structure were obtained by introducing chemical pressure, where the unique ferroelectric domain structures of sixfold vortex combined with tenfold vortex with a typical size of ~400 nm were determined. Symmetry of the present system evolved from centrosymmetric orthorhombic Pbnm (x = 0–0.4) to non‐centrosymmetric hexagonal P63cm (x = 0.5 and 0.6) with a ferroelectric polarization up to 3.2 μC/cm2, and finally to centrosymmetric hexagonal P63/mmc (x = 0.7 and 0.8). The Curie point decreased monotonically from 723 K to a temperature below room temperature with increasing x, and the antiferromagnetic phase transition above room temperature was determined for all compositions. Meanwhile, a large linear magnetoelectric coefficient (αME) up to 0.96 mV/cm Oe was obtained at room temperature, and this indicated the great application potential for magnetoelectric devices.
Abusive leadership versus objectifying job features: Factors that influence organizational dehumanization and workers’ self‐objectification
Authors: Sainz Mario , Baldissarri Cristina 
Published: June 2021

AbstractRecent research has revealed that work often can undermine people's humanness by promoting a view of them as mere objects. In particular, the workers’ meta‐perceptions of being treated as company resources (i.e., organizational dehumanization) and their self‐perceptions of being instrument‐like (i.e., self‐objectification) could be triggered by several factors. Previous research has identified that abusive supervisors and engaging in objectifying (repetitive, fragmented and other oriented) tasks are two of the main key factors that affect worker's dehumanization. The present project aims to disentangle the extent both factors (perceptions of abusive leadership and performing objectifying tasks) contribute to created perceptions of organizational dehumanization and self‐objectification among workers that, ultimately, affects workers job satisfaction. In Study 1 (N = 208 workers), we measured the extent perceived abusive supervisors and objectifying job features predicted organizational dehumanization, self‐objectification, and job satisfaction. The results indicate that abusive supervisors predicted perceptions of organizational dehumanization and workers self‐objectification in a higher extent than objectifying job features, while workers job satisfaction was predicted in a higher extent by objectifying job features. In Study 2 (N = 141), we experimentally manipulated the abusive (versus nonabusive) supervisors and the objectifying (versus nonobjectifying) tasks in a laboratory setting. Results also indicated that the abusive supervisor exerts a greater influence than performing objectifying tasks on organizational dehumanization, self‐objectification, and job satisfaction. The detrimental effect of an abusive supervisor in comparison with other working conditions on workers’ humanness is discussed, and practical implications are highlighted.
Overexpression of miR‐19a and miR‐20a in iPS‐MSCs preserves renal function of chronic kidney disease with acute ischaemia‐reperfusion injury in rat
Authors: Lee Mel S. , Yip Hon‐Kan , Yang Chih‐Chao , Chiang John Y. , Huang Tien‐Hung , Li Yi‐Chen , Chen Kuan‐Hung , Sung Pei‐Hsun 
Published: June 2021

AbstractThis study tested the hypothesis that therapy with double overexpression of miR‐19a‐3p and miR‐20a‐5p (miRDOE) to human inducible pluripotent stem cell–derived mesenchymal stem cells (iPS‐MSCs) was superior to iPS‐MSCs alone for preserving renal function in rat with pre‐existing chronic kidney disease (CKD), followed by ischaemia‐reperfusion (IR) injury. In vitro study demonstrated that the protein expressions of oxidative stress (NOX‐1/NOX‐2/NOX4/oxidized protein/p22phox), inflammatory downstream signalling (TLR2&4/MyD88/TRAF6/IKK‐ß/p‐NFκB/IL‐1ß/IL‐6/MMP‐9) and cell apoptosis/death signalling (cleaved caspase‐3/mitochondrial Bax/p‐ERKs/p‐JNK/p‐p38) at time‐points of 24‐hour/48‐hour cell cultures were significantly increased in p‐Cresol‐treated NRK‐52E cells than in the control that was significantly reversed by miR‐19a‐3p‐transfected iPS‐MSC (all P < .001). Animals were categorized into group 1 (sham‐operated control), group 2 (CKD‐IR), group 3 (CKD‐IR + oligo‐miRDOE of iPS‐MSCs/6.0 ×105/intra‐renal artery transfusion/3 hours after IR procedure), group 4 (CKD‐IR + iPS‐MSCs) and group 5 (CKD‐IR + miRDOE of iPS‐MSCs/6.0 ×105/intra‐renal artery transfusion/3 hour after IR procedure). By day 35, the creatinine/BUN levels were lowest in group 1, highest in group 2 and significantly lower in group 5 than in groups 3 and 4 (all P < .0001) but they showed no difference between the latter two groups. The protein expressions of oxidative stress, inflammatory downstream signalling and cell apoptosis/death signalling exhibited an identical pattern of creatinine level among the five groups (all P < .00001). Also, the microscopic findings demonstrated that the kidney injury score/fibrotic area/number of inflammatory cells (CD14+/CD68+) exhibited an identical pattern of creatine level (all P < .0001). The miRDOE of iPS‐MSCs was superior to iPS‐MSCs for preserving the residual kidney function and architecture in CKD‐IR rat.
Impact of chronic smoking on traumatic brain microvascular injury: An in vitro study
Authors: Sivandzade Farzane , Alqahtani Faleh , Cucullo Luca 
Published: June 2021

AbstractTraumatic brain injury (TBI) is a major reason of cerebrovascular and neurological damage. Premorbid conditions such as tobacco smoking (TS) can worsen post‐TBI injuries by promoting vascular endothelial impairments. Indeed, TS‐induced oxidative stress (OS) and inflammation can hamper the blood‐brain barrier (BBB) endothelium. This study evaluated the subsequence of chronic TS exposure on BBB endothelial cells in an established in vitro model of traumatic cell injury. Experiments were conducted on confluent TS‐exposed mouse brain microvascular endothelial cells (mBMEC‐P5) following scratch injury. The expression of BBB integrity–associated tight junction (TJ) proteins was assessed by immunofluorescence imaging (IF), Western blotting (WB) and quantitative RT‐PCR. We evaluated reactive oxygen species (ROS) generation, the nuclear factor 2–related (Nrf2) with its downstream effectors and several inflammatory markers. Thrombomodulin expression was used to assess the endothelial haemostatic response to injury and TS exposure. Our results show that TS significantly decreased Nrf2, thrombomodulin and TJ expression in the BBB endothelium injury models while increased OS and inflammation compared to parallel TS‐free cultures. These data suggest that chronic TS exposure exacerbates traumatic endothelial injury and abrogates the protective antioxidative cell responses. The downstream effect was a more significant decline of BBB endothelial viability, which could aggravate subsequent neurological impairments.
Dinoprostone vaginal insert (DVI) versus adjunctive sweeping of membranes andDVIfor term induction of labor
Authors: Bhatia Anju , Teo Puay Ling , Li Mingyue , Lee Jia Ying Beatrice , Chan Mei Xin Joanne , Yeo Tai Wai , Mathur Manisha , Tagore Shephali , Yeo George S. H. , Arulkumaran Sabaratnam 
Published: June 2021

AbstractAimTo compare the efficacy and safety of dinoprostone vaginal insert (DVI) alone versus DVI with adjunctive sweeping of membranes (ASM) for induction of labor (IOL).MethodsSingle‐center, prospective, randomized controlled trial; women with singleton term pregnancies, cervical dilation ≥1 and <3 cm, intact membranes allocated to either DVI or DVI with ASM. The primary outcome was vaginal delivery within 24 h of insertion. Secondary outcomes included mean time from insertion to delivery, tachysystole, operative delivery for non‐reassuring fetal status (NRFS), tocolytics, fetal outcomes, pain information, and subject satisfaction.ResultsOne hundred and four received DVI (Group 1) alone and 104 DVI with ASM (Group 2). The rate of vaginal delivery within 24 h was 53% versus 56%, cesarean rate 8.7% versus 10.6% in Groups 1 and 2 respectively. Although the duration of labor was similar in both groups, about 6% of women required additional ripening with dinoprostone vaginal tablets in Group 2 compared to 11.5% in Group 1 (p‐value = 0.2). The frequency of hyperstimulation syndrome, failed induction, analgesic requirements, and fetal outcomes were comparable. The majority (83%–86%) in either cohort were satisfied with their labor experience. Multivariate logistic regression demonstrated a slightly better chance for vaginal delivery within 24 h (odds ratio [OR] 1.22 [95% confidence interval, CI 0.65–2.29];p‐value 0.53] for DVI with ASM, although statistically insignificant. Younger maternal age and multiparity (OR 10.36 [95% CI 4.88–23.67];p‐value <0.0001) contributed to successful IOL.ConclusionDVI with ASM is at least as efficacious as DVI for cervical ripening with no increase in morbidity. Although DVI with ASM group less often needed additional dinoprostone tablets to complete the process of IOL (p‐value = 0.2), adjunctive sweeping has not been shown to have a significant impact on the duration of labor or mode of delivery.
Survival Rates of Splinted and Nonsplinted Prostheses Supported by Short Dental Implants (≤8.5 mm): A Systematic Review and Meta‐Analysis
Authors: Li Qiu‐Lan , Yao Mian‐Feng , Cao Ruo‐Yan , Zhao Ke , Wang Xiao‐Dong 
Published: June 2021

AbstractPurposeTo evaluate and compare the implant survival rates, marginal bone loss, and mechanical complications of prostheses supported by splinted and nonsplinted short implants (≤8.5 mm).Material and MethodsElectronic database (MEDLINE, CENTRAL, Web of Science, and EMBASE) and manual searches up to May 2021 were conducted to identify studies comparing splinted and nonsplinted short implants (≤8.5 mm). The primary outcome was implant survival rate. Secondary outcomes were marginal bone loss and mechanical complications. The quality of included studies and risk‐of‐bias were assessed according to the Newcastle‐Ottawa Scale. A random‐effects model was used to analyze the data.ResultsTwelve studies fulfilled the inclusion criteria and featured 1506 short implants (596 nonsplinted and 910 splinted) with a follow‐up time ranging from 1 to 16 years. Quantitative analysis found no statistically significant differences between splinted and nonsplinted short implants (≤8.5 mm) for survival rate (RR = 0.98; 95% CI 0.96, 1.01; p = 0.26)) and marginal bone loss (SMD = –0.08; 95% CI – 0.23, 0.07; p = 0.28). Veneer chipping, abutment screw breakage, screw loosening, and loss of retention were reported in the selected studies as common complications. However, no statistically significant difference was found between splinted and nonsplinted short implants (RR = 0.56; 95% CI 0.20, 1.54; p = 0.26).ConclusionsWithin the limitations of the present meta‐analysis, it might be concluded that splinted short implants (≤8.5 mm) do not present superior performance in survival rate, marginal bone maintenance and prevention of mechanical complications compared with single‐unit prostheses.
Nutrition‐Exercise Behaviors, Health Literacy Level, and Related Factors in Adolescents in Turkey
Authors: Ayaz‐Alkaya Sultan , Kulakçı‐Altıntaş Hülya 
Published: June 2021

ABSTRACTBACKGROUNDHealth behaviors of adolescents affect their health and well‐being into adulthood. This study was conducted to determine the nutrition‐exercise behaviors, health literacy level, and related factors in adolescents.METHODSA cross‐sectional design was used for this study. Overall, 810 students in grades 6–8 in a Turkish school completed the study. A personal information form, the Nutrition‐Exercise Behaviors Scale, and the Health Literacy for School‐Aged Children Scale were used for data collection.RESULTSAccording to the mean score of the Health Literacy Scale, 21% of the students had a low level of health literacy, 63.8% had a medium level, and 15.2% had a high level. A positive correlation was found between health literacy level and healthy nutrition‐exercise behavior (r = 0.345, p < .001), and a positive correlation between health literacy level and meal pattern (r = 0.230, p < .001). A positive correlation (r = 0.385, p < .001) was found between meal pattern and healthy nutrition‐exercise behavior. A moderate positive correlation (r = 0.510, p < .001) was found between unhealthy nutrition‐exercise behavior and psychological/addicted eating behavior.CONCLUSIONThe present study revealed that nutrition‐exercise behaviors and the health literacy of adolescents were at a moderate level and, there was a relationship between nutrition‐exercise behaviors and health literacy levels in adolescents. Interventions should be planned and followed through with parents to help adolescents adopt healthy nutrition and exercise behaviors from an early age and to increase their health literacy level. In this context, it is recommended to implement training and intervention programs for adolescents and their families.