bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-cultural adaptations of the Family Resilience Assessment Scale: a systematic review protocol of measurement properties
Authors: Laporte Geneviève , De Clifford-Faugère Gwenaëlle , Aita Marilyn 
Published: September 2021

ABSTRACT

Objective:
This review aims to critically appraise the measurement properties and adaptation processes of all cross-cultural adaptations of the Family Resilience Assessment Scale.

Background:
A number of family resilience instruments have been developed over the past decade; however, the Family Resilience Assessment Scale reports the best psychometric properties among populations with health issues. Since its publication in 2005, numerous translations and adaptations have been undertaken to use this scale with culturally diverse populations. A systematic review of the properties of the Family Resilience Assessment Scale's cross-cultural adaptations is needed to evaluate the adapted versions’ quality (validity, reliability, and responsiveness).

Inclusion criteria:
This review will consider validation and cross-cultural adaptation studies of the Family Resilience Assessment Scale as well as research publications reporting psychometric properties of cross-cultural adaptations in specific populations.

Methods:
Nine databases will be consulted: CINAHL, PubMed, Embase, PsycINFO, PubPsych, Health and Psychosocial Instruments database, ProQuest Dissertations and Theses, ScienceDirect, and Web of Science. The search will be limited to publications since 2005 without language restrictions. Articles will be screened by two independent reviewers and will undergo risk of bias assessment. The measurement properties of retrieved instruments will be assessed following COSMIN guidelines. Data extraction will be piloted and completed by two independent reviewers using an adapted extraction form. Psychometric properties will be reported in a narrative synthesis and supported by a summary table.

Systematic review registration number:
PROSPERO CRD42020219938
Parameter Identification From Normal and Pathological Middle Ears Using a Tailored Parameter Identification Algorithm
Authors: Sackmann Benjamin , Eberhard Peter , Lauxmann Michael 
Published: September 2021

Abstract
Current clinical practice is often unable to identify the causes of conductive hearing loss in the middle ear with sufficient certainty without exploratory surgery. Besides the large uncertainties due to interindividual variances, only partially understood cause–effect principles are a major reason for the hesitant use of objective methods such as wideband tympanometry in diagnosis, despite their high sensitivity to pathological changes. For a better understanding of objective metrics of the middle ear, this study presents a model that can be used to reproduce characteristic changes in metrics of the middle ear by altering local physical model parameters linked to the anatomical causes of a pathology. A finite-element model is, therefore, fitted with an adaptive parameter identification algorithm to results of a temporal bone study with stepwise and systematically prepared pathologies. The fitted model is able to reproduce well the measured quantities reflectance, impedance, umbo and stapes transfer function for normal ears and ears with otosclerosis, malleus fixation, and disarticulation. In addition to a good representation of the characteristic influences of the pathologies in the measured quantities, a clear assignment of identified model parameters and pathologies consistent with previous studies is achieved. The identification results highlight the importance of the local stiffness and damping values in the middle ear for correct mapping of pathological characteristics and address the challenges of limited measurement data and wide parameter ranges from the literature. The great sensitivity of the model with respect to pathologies indicates a high potential for application in model-based diagnosis.
Simplified Mechanical Tests Can Simulate Physiological Mechanics of a Fixation Construct for Periprosthetic Femoral Fractures
Authors: Chen Xiang , Myers Casey A. , Clary Chadd W. , DeWall Ryan J. , Fritz Bryan , Blauth Michael , Rullkoetter Paul J. 
Published: September 2021

Abstract
Plate fractures after fixation of a Vancouver Type B1 periprosthetic femoral fracture (PFF) are difficult to treat and could lead to severe disability. However, due to the lack of direct measurement of in vivo performance of the PFF fixation construct, it is unknown whether current standard mechanical tests or previous experimental and computational studies have appropriately reproduced the in vivo mechanics of the plate. To provide a basis for the evaluation and development of appropriate mechanical tests for assessment of plate fracture risk, this study applied loads of common activities of daily living (ADLs) to implanted femur finite element (FE) models with PFF fixation constructs with an existing or a healed PFF. Based on FE simulated plate mechanics, the standard four-point-bend test adequately matched the stress state and the resultant bending moment in the plate as compared with femur models with an existing PFF. In addition, the newly developed constrained three-point-bend tests were able to reproduce plate stresses in models with a healed PFF. Furthermore, a combined bending and compression cadaveric test was appropriate for risk assessment including both plate fracture and screw loosening after the complete healing of PFF. The result of this study provides the means for combined experimental and computational preclinical evaluation of PFF fixation constructs.
Average Modeling and Nonlinear Observer Design for Pneumatic Actuators With On/Off Solenoid Valves
Authors: Laib Khaled , Pham Minh Tu , Lin-Shi Xuefang , Meghnous Rédha 
Published: September 2021

Abstract
This paper presents a state-averaged model and the design of nonlinear observers for an on/off pneumatic actuator. The actuator is composed of two chambers and four on/off solenoid valves. The elaborated state-averaged model has the advantage of using only one continuous input instead of four binary inputs. Based on this new model, a high-gain observer and a sliding-mode observer are designed using the actuator position and the pressure measurements in one of the chambers. Finally, their closed-loop performance is verified and compared on an experimental benchmark.
Research on Creep Behavior of Three-Point Bending Specimen With Fixed Constraints at the Large Deformation Stage
Authors: Han Xiao , Yu Hai-Yang , Zhou Guo-Yan , Zhuang Fa-Kun , Tu Shan-Tung 
Published: September 2021

AbstractThree-point bending specimen with fixed constraints is a novel small specimen test technique, which can simultaneously obtain creep deformation and creep fracture data. However, the current research only focused on the small deformation theoretical analysis, which is contrary to the actual experiment results. In this study, the general deformation theory was introduced to analyze creep deformation behavior of three-point bending specimen with fixed constraints at the large deformation stage. Based on this theory, the equivalent stress and strain were analyzed. Then, the feasibility and accuracy were verified by comparing with the experimental data of A7N01 aluminum alloy at 380 °C. The results show that the regressed creep parameters agree well with those from the uni-axial ones. It can be found that the equivalent stress obtained by the general deformation theory can be well used to life prediction analysis of A7N01 aluminum alloy.
The Composition, Structure, and Origin of Carbonate Concretions Sampled in the South Kambalnyi Central Thermal Field, Kamchatka
Authors: Rychagov S. N. , Sandimirova E. I. , Chernov M. S. , Kravchenko O. V. , Kartasheva E. V. 
Published: September 2021

AbstractCarbonate concretions are formed at the base of a sequence of hydrothermal clay in the South Kambalnyi Central Thermal Field situated in the southern part of the Kambalnyi volcanic mountain range, Kamchatka. The concretions have complex chemical and mineral compositions: apart from aragonite which is the main component of each layer, the chemical compounds identified there include oxides of iron and silicon, sulfates of calcium and barium, sulfides of iron and other metals, carbonates of iron and manganese, siliceous ferromanganese formations, nitrogen compounds, and phosphates of calcium and rare metals. The concretions have diverse structures and textures that indicate a multiphase character of formation for these mineral aggregates. It is thought that their formation was due to the discharge of deep-seated alkaline metalliferous solutions in a zone of rock argillization of the South Kambalnyi Central Thermal Field.
Normalish Amenable Subgroups of the R. Thompson Groups
Authors: Bleak Collin 
Published: September 2021

Results in [Formula: see text] algebras, of Matte Bon and Le Boudec, and of Haagerup and Olesen, apply to the R. Thompson groups [Formula: see text]. These results together show that [Formula: see text] is non-amenable if and only if [Formula: see text] has a simple reduced [Formula: see text]-algebra. In further investigations into the structure of [Formula: see text]-algebras, Breuillard, Kalantar, Kennedy, and Ozawa introduce the notion of a normalish subgroup of a group [Formula: see text]. They show that if a group [Formula: see text] admits no non-trivial finite normal subgroups and no normalish amenable subgroups then it has a simple reduced [Formula: see text]-algebra. Our chief result concerns the R. Thompson groups [Formula: see text]; we show that there is an elementary amenable group [Formula: see text] [where here, [Formula: see text]] with [Formula: see text] normalish in [Formula: see text]. The proof given uses a natural partial action of the group [Formula: see text] on a regular language determined by a synchronising automaton in order to verify a certain stability condition: once again highlighting the existence of interesting intersections of the theory of [Formula: see text] with various forms of formal language theory.
The Relationship Between Breast Density Change During Menopause and the Risk of Breast Cancer in Korean Women
Authors: Kang Danbee , Kim Ji-Yeon , Kim Ji-Young , Mun Han Song , Yoon Sook Ja , Lee Jieun , Han Gayeon , Im Young-Hyuck , Shin Soo-Young , Lee Se Kyung , Yu Jong-Han , Lee Kyung-Hyun , Kim Mincheol , Park Dohyun , Choi Yoon-Ho , Jeong Ok Soon , Lee Jean Hyoung , Jekal Se Yong , Choi Jong Soo , Guallar Eliseo , Chang Yoosoo , Ryu Seungho , Cho Juhee , Kang Mira 
Published: September 2021

AbstractBackground:The aim of this study was to investigate the relationship between changes in breast density during menopause and breast cancer risk.Methods:This study was a retrospective, longitudinal cohort study for women over 30 years of age who had undergone breast mammography serially at baseline and postmenopause during regular health checkups at Samsung Medical Center. None of the participants had been diagnosed with breast cancer at baseline. Mammographic breast density was measured using the American College of Radiology Breast Imaging Reporting and Data System.Results:During 18,615 person-years of follow-up (median follow-up 4.8 years; interquartile range 2.8–7.5 years), 45 participants were diagnosed with breast cancer. The prevalence of dense breasts was higher in those who were younger, underweight, had low parity or using contraceptives. The cumulative incidence of breast cancer increased 4 years after menopause in participants, and the consistently extremely dense group had a significantly higher cumulative incidence (CI) of breast cancer compared with other groups [CI of extremely dense vs. others (incidence rate per 100,000 person-years): 375 vs. 203, P &lt; 0.01].Conclusion:Korean women whose breast density was extremely dense before menopause and who maintained this density after menopause were at two-fold greater risk of breast cancer.Prevention Relevance:Extremely dense breast density that is maintained persistently from premenopause to postmenopause increases risk of breast cancer two fold in Korean women. Therefore, women having risk factors should receive mammography frequently and if persistently extremely dense breast had been detected, additional modalities of BC screening could be considered.
Phase II Trial of Pembrolizumab after High-Dose Cytarabine in Relapsed/Refractory Acute Myeloid Leukemia
Authors: Zeidner Joshua F. , Vincent Benjamin G. , Ivanova Anastasia , Moore Dominic , McKinnon Karen P. , Wilkinson Alec D. , Mukhopadhyay Rupkatha , Mazziotta Francesco , Knaus Hanna A. , Foster Matthew C. , Coombs Catherine C. , Jamieson Katarzyna , Van Deventer Hendrik , Webster Jonathan A. , Prince Gabrielle T. , DeZern Amy E. , Smith B. Douglas , Levis Mark J. , Montgomery Nathan D. , Luznik Leo , Serody Jonathan S. , Gojo Ivana 
Published: September 2021

Abstract

Immune suppression, exhaustion, and senescence are frequently seen throughout disease progression in acute myeloid leukemia (AML). We conducted a phase II study of high-dose cytarabine followed by pembrolizumab 200 mg i.v. on day 14 to examine whether PD-1 inhibition improves clinical responses in relapsed/refractory (R/R) AML. Overall responders could receive pembrolizumab maintenance up to 2 years. Among 37 patients enrolled, the overall response rate, composite complete remission (CRc) rate (primary endpoint), and median overall survival (OS) were 46%, 38%, and 11.1 months, respectively. Patients with refractory/early relapse and those receiving treatment as first salvage had encouraging outcomes (median OS, 13.2 and 11.3 months, respectively). Grade ≥3 immune-related adverse events were rare (14%) and self-limiting. Patients who achieved CRc had a higher frequency of progenitor exhausted CD8+ T cells expressing TCF-1 in the bone marrow prior to treatment. A multifaceted correlative approach of genomic, transcriptomic, and immunophenotypic profiling offers insights on molecular correlates of response and resistance to pembrolizumab.

Significance:
Immune-checkpoint blockade with pembrolizumab was tolerable and feasible after high-dose cytarabine in R/R AML, with encouraging clinical activity, particularly in refractory AML and those receiving treatment as first salvage regimen. Further study of pembrolizumab and other immune-checkpoint blockade strategies after cytotoxic chemotherapy is warranted in AML.
See related commentary by Wei et al., p. 551.
This article is highlighted in the In This Issue feature, p. 549
Um homem bom etc.
Authors: Leite Ligia Chiappini Moraes 
Published: September 2021

O título alude ao livro de Antonio Candido, Teresina etc. Rio de Janeiro: Ouro sobre azul, 2007.
Uma primeira versão deste texto foi publicada, com cortes, devido a limitações de espaço, no boletim online do IEB, logo depois da morte de Antonio Candido, a convite de Sandra Nitrini. Uma tradução em alemão, para a página do Instituto Latino americano de Universidade Livre de Berlim (Freie Universität Berlin) foi depois publicada numa versão sem cortes. Agora retomo aqui o texto completo em português, mas novamente adaptando-o ao novo veículo, a revista Literatura e Sociedade, do Departamento de Teoria Literária e Literatura Comparada, porque algumas notas mais factuais, com informações que interessavam ao projeto deste número, foram acrescentadas, a pedido da sua comissão editorial. Isso pode explicar o caráter dual do texto que aqui se publica, entre meio ficcional e informativo. Nele procurei unir boa parte das informações, que me foram solicitadas em 12 perguntas, com a tentativa de entender e expressar a figura do Mestre como uma combinação indissolúvel de alta intelectualidade, simplicidade e profunda riqueza humana, com pouco açúcar e muito afeto.
Em tempo, gostaria de agradecer aos colegas responsáveis por este numero de Literatura e Sociedade, por terem concordado com minha proposta deste texto hibrido.
Editorial
Authors: Vidal Ariovaldo , Otsuka Edu Teruki , Fonseca Maria Augusta Bernardes 
Published: September 2021

Em 2021, a revista Literatura e Sociedade lança uma edição especial, dedicada à formação da Área de Teoria Literária e Literatura Comparada, para celebrar seus 60 anos, através de uma compilação de depoimentos e documentos.Com exceção feita à professora Sandra Nitrini, que elaborou um histórico do Departamento de Teoria Literária e Literatura Comparada, os demais colaboradores pertenceram ao primeiro núcleo de professores de Teoria Literária e Literatura Comparada da USP, a maioria instalada no Prédio da Rua Maria Antônia. Em Depoimentos, além de Nitrini, Adelia Bezerra de Meneses, João Alexandre Barbosa, Ligia Chiappini Moraes Leite e Teresa Pires Vara.Constam também os Memoriais Acadêmicos dos professores Antonio Candido, João Alexandre Barbosa, João Luiz Lafetá e Davi Arrigucci Jr., além do Memorial de Roberto Schwarz, professor que no início de sua carreira atuou na Área. Há ainda os discursos de agradecimento pelo título de Professor Emérito recebido por dois docentes do Departamento, Walnice Nogueira Galvão, Davi Arrigucci Jr. e por seu fundador.Em Entrevistas, vários dos professores mencionados dão seu depoimento memorialístico na forma de diálogo geralmente com alunos, o que no conjunto forma um grande quadro das linhas de força e atuação na história do Departamento, entrevistas nas quais comparecem também dois colegas da Área de Russo – Boris Schnaiderman e Aurora Fornoni Bernardini.Na variada reunião de textos aqui apresentados – como uma carta-documento enviada por Antonio Candido a João Alexandre Barbosa, contando da criação da Área –, encontra-se também um texto elaborado pelo professor João Luiz Lafetá abordando modificações no programa de Mestrado no Departamento de Teoria Literária e Literatura Comparada. Além desse, alguns documentos oficiais como o Pedido de Formação do DTLLC, assinado pela professora Walnice Nogueira Galvão, os Pareceres dos professores Celso de Rui Beisiegel e Jobson de Andrade Arruda e finalmente a Resolução e a Portaria que deram existência formal ao Departamento de Teoria Literária e Literatura Comparada.
Identifying Discordance of Right- and Left-Ventricular Filling Pressures in Patients With Heart Failure by the Clinical Examination
Authors: Pham David D. , Drazner Mark H. , Ayers Colby R. , Grodin Justin L. , Hardin Elizabeth A. , Garg Sonia , Mammen Pradeep P. A. , Amin Alpesh , Araj Faris G. , Morlend Robert M. , Thibodeau Jennifer T. 
Published: September 2021

Background:
In ≈25% of patients with heart failure and reduced left-ventricular ejection fraction, right-ventricular (RV), and left-ventricular (LV) filling pressures are discordant (ie, one is elevated while the other is not). Whether clinical assessment allows detection of this discordance is unknown. We sought to determine the agreement of clinically versus invasively determined patterns of ventricular congestion.

Methods:
In 156 heart failure and reduced LV ejection fraction subjects undergoing invasive hemodynamic assessment, we categorized patterns of ventricular congestion (no congestion, RV only, LV only, or both) based on clinical findings of RV (jugular venous distention) or LV (hepatojugular reflux, orthopnea, or bendopnea) congestion. Agreement between clinically and invasively determined (RV congestion if right atrial pressure [RAP] ≥10 mm Hg and LV congestion if pulmonary capillary wedge pressure [PCWP] ≥22 mm Hg) categorizations was the primary end point.

Results:
The frequency of clinical patterns of congestion was: 51% no congestion, 24% both RV and LV, 21% LV only, and 4% RV only. Jugular venous distention had excellent discrimination for elevated RAP (C=0.88). However, agreement between clinical and invasive congestion patterns was poor, к=0.44 (95% CI, 0.34–0.55). While those with no clinical congestion usually had low RAP and PCWP (67/79, 85%), over one-half (24/38, 64%) with isolated LV clinical congestion had PCWP <22 mm Hg, most (5/7, 71%) with isolated RV clinical congestion had PCWP ≥22 mm Hg, and ≈one-third (10/32, 31%) with both RV and LV clinical congestion had elevated RAP but PCWP <22 mm Hg.

Conclusions:
While clinical examination allows accurate detection of elevated RAP, it does not allow accurate detection of discordant RV and LV filling pressures.
Abnormalities of bone marrow B cells and plasma cells in primary immune thrombocytopenia
Authors: Yu Tian-shu , Wang Hao-yi , Zhao Ya-jing , Yu Ya-fei , Hou Yu , Liu Shuang , Han Pan-pan , Ni Xiao-fei , Ji Xue-bin , Peng Jun , Liu Xin-guang , Hou Ming 
Published: September 2021

Abstract
Primary immune thrombocytopenia (ITP) is an autoantibody-mediated hemorrhagic disorder in which B cells play an essential role. Previous studies have focused on peripheral blood (PB), but B cells in bone marrow (BM) have not been well characterized. We aimed to explore the profile of B-cell subsets and their cytokine environments in the BM of patients with ITP to further clarify the pathogenesis of the disease. B-cell subpopulations and their cytokine/chemokine receptors were detected by using flow cytometry. Plasma concentrations of cytokines/chemokines were measured by using enzyme-linked immunosorbent assay. Messenger RNA levels of B cell–related transcription factors were determined by using quantitative polymerase chain reaction. Regulatory B cell (Breg) function was assessed by quantifying their inhibitory effects on monocytes and T cells in vitro. Decreased proportions of total B cells, naive B cells, and defective Bregs were observed in patients with ITP compared with healthy controls (HCs), whereas an elevated frequency of long-lived plasma cells was found in BM of autoantibody-positive patients. No statistical difference was observed in plasmablasts or in short-lived plasma cells between patients with ITP and HCs. The immunosuppressive capacity of BM Bregs from patients with ITP was considerably weaker than HCs. An in vivo study using an active ITP murine model revealed that Breg transfusion could significantly alleviate thrombocytopenia. Moreover, overactivation of CXCL13-CXCR5 and BAFF/APRIL systems were found in ITP patient BM. Taken together, B-cell subsets in BM were skewed toward a proinflammatory profile in patients with ITP, suggesting the involvement of dysregulated BM B cells in the development of the disease.