bluuebunny/crossref_metadata_2025_split huggingface dataset:
How phosphorylation of peptides affects their interaction with 14‐3‐3η domains
Authors: Künzel Nicolas , Helms Volkhard 
Published: August 2021

AbstractMembers of the 14‐3‐3 domain family have important functions as adapter domains. Via an amphipathic groove on their protein surface they typically bind to disordered C‐terminals of other proteins. Importantly, binding partners of 14‐3‐3 domains usually contain a phosphorylated serine or threonine residue at their binding interface and possess one of three different sequence motifs. Binding of the respective unphosphorylated versions of the peptides is typically strongly disfavored. There is a wealth of structural and thermodynamic data available for the phosphorylated forms but not for the unphosphorylated forms as the binding affinities seem to be too weak to be measurable experimentally. Here, we characterized the mechanistic details that govern the preference for the binding of phosphorylated peptides to 14‐3‐3η domains by means of molecular dynamics (MD) simulations. We found that the phosphate group is ideally coordinated in the binding pocket whereas the respective unphosphorylated side‐chain counterpart is not. Thus, the binding preference results from the tight coordination of the phosphorylated residue at the center of the binding interface. Furthermore, MD simulations of 14‐3‐3η dimers showed a preference for the simultaneous binding of two phosphorylated peptides in agreement with their experimentally observed cooperativity.
Aircraft observations and sub‐km modelling of the lake–land breeze circulation over Lake Victoria
Authors: Woodhams Beth J. , Barrett Paul A. , Marsham John H. , Birch Cathryn E. , Bain Caroline L. , Fletcher Jennifer K. , Hartley Andrew J. , Webster Stuart , Mangeni Solomon 
Published: August 2021

AbstractThe lake–land breeze circulation over Lake Victoria was observed in unprecedented detail with a research aircraft during the HyVic pilot flight campaign in January 2019. An evening and morning flight observed the lake and land breezes respectively under mostly dry conditions. The circulation was observed at various heights along a transect across the lake and onshore in Tanzania. Profiles of the lower troposphere were recorded by dropsondes over the lake and land. Convection‐permitting MetUM simulations with different horizontal grid‐spacings (including sub‐km) were run for the flight periods. During the evening flight, the aircraft crossed the lake breeze front over land at 1627 LT, approximately 50 km to the east of the lake shore, recording a 6 gkg decrease in specific humidity and reversal in wind direction over 5 km. During the morning flight, a shallow land breeze was observed across the eastern shore at 0545 LT. At least one region of increased and deeper moisture (previously seen in simulations but never observed) was sampled over the lake surface between 0527 and 0855 LT. This bulge of moisture was likely formed from the lifting of near‐surface moist air above the lake by low‐level convergence. The observations and model simulations suggest that low‐level convergence occurred at the leading edge of the land breeze, which had detached from the main land breeze and independently propagated westward across the lake with wave‐like characteristics. The MetUM simulations were able to reasonably reproduce the lake breeze front, bulge feature, and its propagation, which is a major achievement given the sparse observational data for model initialisation in this region. However, some timing, resolution and boundary‐layer depth biases require further investigation. Overall, this pilot campaign provided an unprecedented snapshot of the Lake Victoria lake–land breeze circulation and motivates a more comprehensive field campaign in the future.
Diffuse pulmonary calcifications: A case series and review of literature
Authors: Jarjou'i Amir , Bogot Naama , Kalak George , Chen‐Shuali Chen , Rokach Ariel , Izbicki Gabriel , Arish Nissim 
Published: August 2021

AbstractPulmonary calcifications are usually incidental asymptomatic findings discovered on x‐rays or computed tomography scans that can be easily overlooked, and their significance undermined, especially in a seemingly asymptomatic person. Calcifications can be a marker of chronicity or disease severity, and thus have diagnostic value. Rarely, calcification can be the direct cause of morbidity. Calcifications can be either localized or diffuse. Many diseases, in particular infectious diseases, can cause localized calcifications. Diffuse calcifications are less common and usually secondary to a handful of conditions such as dystrophic pulmonary calcifications, metastatic pulmonary calcifications, disseminated pulmonary ossifications and pulmonary alveolar microlithiasis. We describe three cases of diffuse pulmonary calcifications, review the different causes of diffuse pulmonary calcifications and provide some indicators on how to differentiate between them. Differentiating between the different types of pulmonary calcifications has significant implications on the management and prognosis of the patients, and thus it is important to distinguish between them.
The dynamic linkage between remittances, export diversification, education, renewable energy consumption, economic growth, and CO2 emissions in top remittance‐receiving countries
Authors: Zafar Muhammad Wasif , Saleem Muhammad Mansoor , Destek Mehmet Akif , Caglar Abdullah Emre 
Published: August 2021

AbstractIn recent years, the literature on financial development, public finance, and other areas has substantially increased; however, remittances are among the most neglected sources with significantly larger resource inflow that may serve the purpose of reducing environmental degradation. The literature on export diversification and education is also limited, with conflicting findings. With this in mind, the current research examined the relationship among remittances, export diversification, education, and CO2 emissions controlling for renewable energy and economic growth in a panel of 22 top remittance‐receiving countries over the period 1986–2017. The study employed second‐generation unit root techniques in econometric methodology, Westerlund and Edgerton cointegration approach with structural breaks, Cup‐FM and CUP‐BC long‐run estimation techniques, and generalized quantile regression method. The findings indicate that remittances help in reducing environmental degradation as they have a negative effect on emissions. Likewise, export diversification reduces CO2 emissions, and renewable energy also contributes to decreasing CO2 emissions. In contrast, economic growth is conducive to environmental degradation. The study also finds a robust estimate of education as a stimulant of environmental degradation. Based on these novel findings, several policy suggestions are discussed.
Xenon Trapping in Metal‐Supported Silica Nanocages
Authors: Xu Yixin , Dorneles de Mello Matheus , Zhou Chen , Sharma Shruti , Karagoz Burcu , Head Ashley R. , Darbari Zubin , Waluyo Iradwikanari , Hunt Adrian , Stacchiola Dario J. , Manzi Sergio , Boscoboinik Alejandro M. , Pereyra Victor D. , Boscoboinik J. Anibal 
Published: August 2021

AbstractXenon (Xe) is a valuable and scarce noble gas used in various applications, including lighting, electronics, and anesthetics, among many others. It is also a volatile byproduct of the nuclear fission of uranium. A novel material architecture consisting of silicate nanocages in contact with a metal surface and an approach for trapping single Xe atoms in these cages is presented. The trapping is done at low Xe pressures and temperatures between 400 and 600 K, and the process is monitored in situ using synchrotron‐based ambient pressure X‐ray photoelectron spectroscopy. Release of the Xe from the cages occurs only when heating to temperatures above 750 K. A model that explains the experimental trapping kinetics is proposed and tested using Monte Carlo methods. Density functional theory calculations show activation energies for Xe exiting the cages consistent with experiments. This work can have significant implications in various fields, including Xe production, nuclear power, nuclear waste remediation, and nonproliferation of nuclear weapons. The results are also expected to apply to argon, krypton, and radon, opening an even more comprehensive range of applications.
Evolvability analysis framework: Adding transition path and stakeholder diversity to infrastructure planning
Authors: Szajnfarber Zoe , Groover Joshua A. , Wei Zhenglin , Broniatowski David A. , Chernicoff William , Helveston John P. 
Published: August 2021

AbstractThis paper presents the Evolvability Analysis Framework (EAF), a new perspective on evaluating complex infrastructure systems. EAF enables decision makers to explore alternative transition paths, thus providing several multi‐step options to achieve a desired end state. These multi‐step transition paths can be particularly valuable when they mitigate the impact of system degradation during the deployment of new capabilities. Additionally, EAF is formulated in a manner that empowers decision makers to apply decision variables, such as a cost cap or an equity metric, which are increasingly relevant to modern decision‐making. To demonstrate the method and its value, we apply the EAF to a case study inspired by Los Angeles’ Vision 2028. We identify 26 transition paths across different performance dimensions. We model the cost and performance of each transition pathway and compare them using multiple measures, including traditional benefit‐cost metrics and differential impacts on different stakeholder groups. Our results show that multi‐step paths outperform single‐step transitions to an end state (“big bang” approaches) in most scenarios. Multi‐step paths also provide valuable alternatives when particular stakeholders value non‐cost metrics.
Shaping the biology of citrus: II. Genomic determinants of domestication
Authors: Gonzalez‐Ibeas Daniel , Ibanez Victoria , Perez‐Roman Estela , Borredá Carles , Terol Javier , Talon Manuel 
Published: August 2021

AbstractWe performed genomic analyses on species and varieties of the genus Citrus to identify several determinants of domestication, based on the pattern of pummelo [Citrus maxima (Burr. f) Merr] and mandarin (Citrus reticulata Blanco) admixture into the ancestral genome, as well as population genetic tests at smaller scales. Domestication impacted gene families regulating pivotal components of citrus flavor (such as acidity) because in edible mandarin varieties, chromosome areas with negative Tajimas values were enriched with genes associated with the regulation of citric acid. Detection of sweeps in edible mandarins that diverged from wild relatives indicated that domestication reduced chemical defenses involving cyanogenesis and alkaloid synthesis, thus increasing palatability. Also, a cluster of SAUR genes in domesticated mandarins derived from the pummelo genome appears to contain candidate genes controlling fruit size. Similarly, conserved stretches of pure mandarin areas were likely important as well for domestication, as, for example, a fragment in chromosome 1 that is involved in the apomictic reproduction of most edible mandarins. Interestingly, our results also support the hypothesis that various genes subject to selective pressure during evolution or derived from whole genome duplication events later became potential targets of domestication.
Higgsed network calculus
Authors: Zenkevich Yegor 
Published: August 2021

Abstract
We introduce a formalism for describing holomorphic blocks of 3d quiver gauge theories using networks of Ding-Iohara-Miki algebra intertwiners. Our approach is very direct and gives an explicit identification of the blocks with Dotsenko-Fateev type integrals for q-deformed quiver W-algebras. We also explain how quiver theories corresponding to Dynkin diagrams of superalgebras arise, write down the corresponding partition functions and W-algebras, and explain the connection with supersymmetric Macdonald-Ruijsenaars commuting Hamiltonians.
Gravity duals of quantum distances
Authors: Yang Run-Qiu 
Published: August 2021

AbstractThis paper provides a holographic approach to compute some most-frequently used quantum distances and quasi-distances in strongly coupling systems and conformal field theories. By choosing modular ground state as the reference state, it finds that the trace distance, Fubini-Study distance, Bures distance and Rényi relative entropy, all have gravity duals. Their gravity duals have two equivalent descriptions: one is given by the integration of the area of a cosmic brane, the other one is given by the Euclidian on-shell action of dual theory and the area of the cosmic brane. It then applies these duals into the 2-dimensional conformal field theory as examples and finds the results match with the computations of field theory exactly.
Epidemiology of burn patients admitted in the Netherlands: a nationwide registry study investigating incidence rates and hospital admission from 2014 to 2018
Authors: Van Yperen Daan T. , Van Lieshout Esther M. M. , Verhofstad Michael H. J. , Van der Vlies Cornelis H. 
Published: August 2021

Abstract
Purpose
The aim of this study was to gain insight into the epidemiology of burn patients admitted to a hospital without a burn center or referred to a burn center.

Methods
This retrospective, nationwide, cohort study included patients with burns or inhalation trauma, admitted between 2014 and 2018, from a national trauma registry. The primary outcome measure was admission to a hospital with or without a burn center. Secondary outcome measures were patient and injury characteristics, Intensive Care Unit (ICU) admission and length of stay, and hospital length of stay (HLOS).

Results
Of the 5524 included patients, 2787 (50.4%) were treated at a non-burn center, 1745 (31.6%) were subsequently transferred to a burn center, and 992 (18.0%) were primarily presented and treated at a burn center. The annual number of patients decreased from 1199 to 1055 (− 12.4%). At all admission locations, a clear incidence peak was observed in children ≤ 4 years and in patients of ≥ 80 years. The number of ICU admissions for the entire population increased from 201 to 233 (33.0%). The mean HLOS for the entire population was 8 (SD 14) days per patient. This number remained stable over the years in all groups.

Conclusion
Half of all burn patients were admitted in a non-burn center and the other half in a burn center. The number and incidence rate of patients admitted with burns or inhalation trauma decreased over time. An increased incidence rate was found in children and elderly. The number of patients admitted to the ICU increased, whereas mean hospital length of stay remained stable.
Component-based structural equation modeling for the assessment of psycho-social aspects and performance of athletes
Authors: Fabbricatore Rosa , Iannario Maria , Romano Rosaria , Vistocco Domenico 
Published: August 2021

AbstractRecent studies have pointed out the effect of personality traits on athletes’ performance and success; however, fewer analyses have focused the relation among these features and specific athletic behaviors, skills, and strategies to enhance performance. To fill this void, the present paper provides evidence on what personality traits mostly affect athletes’ mental skills and, in turn, their effect on the performance of a sample of elite swimmers. The main findings were obtained by exploiting a component-based structural equation modeling which allows to analyze the relationships among some psychological constructs, measuring personality traits and mental skills, and a construct measuring sports performance. The partial least squares path modeling was employed, as it is the most recognized method among the component-based approaches. The introduced method simultaneously encompasses latent and emergent variables. Rather than focusing only on objective behaviors or game/race outcomes, such an approach evaluates variables not directly observable related to sport performance, such as cognition and affect, considering measurement error and measurement invariance, as well as the validity and reliability of the obtained latent constructs. The obtained results could be an asset to design strategies and interventions both for coaches and swimmers establishing an innovative use of statistical methods for maximizing athletes’ performance and well-being.
Impact of climate variability of the Western Tropical Pacific on maximum salinity water in the South China Sea
Authors: Dippner Joachim W. , Weber Sarah C. , Subramaniam Ajit 
Published: August 2021

AbstractSalinity observations in the Vietnamese upwelling area in June 2016 indicated a significant increase in the salinity of the maximum salinity water (MSW). The source of MSW inflow into the South China Sea (SCS) is a mixture of the Western North Pacific Central Water and the North Pacific Equatorial Water. Although the East Asian winter monsoon is correlated with both the El Niño Southern Oscillation (ENSO) and the Pacific Decadal Oscillation (PDO), the mean salinity of MSW is only spuriously lag correlated to the PDO, but highly correlated to all tropical climate modes (except El Niño Modoki) with a time lag up to 7 months. Composite analyses indicate that the modulation of ENSO by a PDO in a positive phase results in optimal inflow conditions. A comparison of two post-El Niño years with different PDO polarity (negative in 2003 and positive in 2016) shows that the dominant driver is the variability in outgoing long-wave radiation (OLR) and in zonal wind in the tropics. In 2003, enhanced convective activity over the West Pacific warm pool resulted in a cyclonic circulation. In 2016, convective activity was weak and an anticyclonic circulation was intensified, which transported the saltier North Pacific Equatorial Water into the SCS. This observed increase in the salinity of MSW requires a modification of the previous definitions of characteristic water masses, which is presented here. The question of whether or not the increase in MSW salinity is a transient phenomenon cannot be answered. It might be possible that the increase in salinity is related to global warming.
Stage of colorectal cancer diagnosis for immigrants: a population-based retrospective cohort study in Ontario, Canada
Authors: Lofters A. K. , Gatov E. , Lu H. , Baxter N. N. , Corrado A. M. , Guilcher S. J. T. , Kopp A. , Vahabi M. , Datta G. D. 
Published: August 2021

Abstract
Background
Colorectal cancer (CRC) is the second most common cause of cancer death in Canada. Immigrants in Ontario, Canada’s most populous province, are known to have lower rates of CRC screening, but differences in stage of CRC diagnosis are not known.

Methods
We utilized linked administrative databases to compare early (stage I–II) versus late (stage III–IV) stage of CRC diagnosis for immigrants versus long-term residents among patients diagnosed in Ontario between 2012 and 2017 (n = 37,717) and examined the association of immigration-related, sociodemographic, and healthcare-related factors with stage.

Results
Almost 45% of those with CRC were diagnosed at a late stage. Immigrants were slightly more likely to be diagnosed at a late stage than their long-term resident counterparts [Adjusted relative risks (ARRs) 1.06 (95% CI 1.02–1.10)], but after adjusting for age and sex, this difference was no longer significant. In fully adjusted models, we observed a higher likelihood of late-stage diagnosis for people with the fewest co-morbidities (ARR 0.86 [95% CI 0.83–0.89]) and those with no visits to primary care (versus a high level of continuity of care) [ARR 1.07 (95% CI 1.03–1.12)].

Conclusion
Immigrants were not more likely to have a late-stage CRC diagnosis after adjusting for relevant factors, but access to primary care and healthcare contact was significantly associated with diagnostic stage.

Impact
Attachment to a primary care provider who provides regular preventive care may play a role in more favorable stage at diagnosis for CRC and thus should be a healthcare system priority.
Controversy around climate change reports: a case study of Twitter responses to the 2019 IPCC report on land
Authors: Sanford Mary , Painter James , Yasseri Taha , Lorimer Jamie 
Published: August 2021

AbstractIn August 2019, the Intergovernmental Panel on Climate Change (IPCC) published its Special Report on Climate Change and Land (SRCCL), which generated extensive societal debate and interest in mainstream and social media. Using computational and conceptual text analysis, we examined more than 6,000 English-language posts on Twitter to establish the relative presence of different topics. Then, we assessed their levels of toxicity and sentiment polarity as an indication of contention and controversy. We find first that meat consumption and dietary options became one of the most discussed issues on Twitter in response to the IPCC report, even though it was a relatively minor element of the report; second, this new issue of controversy (meat and diet) had similar, high levels of toxicity to strongly contentious issues in previous IPCC reports (skepticism about climate science and the credibility of the IPCC). We suggest that this is in part a reflection of increasingly polarized narratives about meat and diet found in other areas of public discussion and of a movement away from criticism of climate science towards criticism of climate solutions. Finally, we discuss the possible implications of these findings for the work of the IPCC in anticipating responses to its reports and responding to them effectively.
Implantable vagus nerve stimulation system performance is not affected by internal or external defibrillation shocks
Authors: Libbus Imad , Stubbs Scott R. , Mazar Scott T. , Mindrebo Scott , KenKnight Bruce H. , DiCarlo Lorenzo A. 
Published: August 2021

Abstract
Purpose
Autonomic regulation therapy (ART) for heart failure (HF) is delivered using vagus nerve stimulation (VNS), and has been associated with improvement in cardiac function and HF symptoms. VNS is delivered using an implantable pulse generator (IPG) and a lead placed around the cervical vagus nerve. Because HF patients may receive concomitant cardiac defibrillation therapy, testing was conducted to determine the effect of defibrillation (DF) on VNS system performance.

Methods
Normal swine (n = 4) with VNS system implants on the right cervical vagus nerve received sequential defibrillation shocks with three defibrillation systems: an implantable cardioverter defibrillator (ICD), a subcutaneous ICD (S-ICD), and an external cardioverter defibrillator (ECD). Each system delivered a series of bipolar high-energy shocks and reverse-polarity high-energy shocks.

Results
The specified cardiac defibrillation shocks were delivered successfully from each of the three defibrillation systems to all animals. After each shock series, interrogation of the IPG confirmed that software and data were unchanged from pre-programmed values. After all of the defibrillation shocks were delivered, the IPGs underwent and passed comprehensive electrical testing demonstrating proper system function. No shifts in IPG parameters or ART system failures were observed, and histologic evaluation of the vagus nerve revealed no anatomic changes.

Conclusions
Implantable VNS systems were tested in vivo for immunity to defibrillation via ICD, S-ICD, and ECD, and were found to be unaffected by a series of high-energy defibrillation shocks. These results confirm that ART systems are capable of continuing to function after defibrillation and the cervical vagus nerve is anatomically unaffected.