bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in the reference evapotranspiration and contributions of climate factors over the Indo–China Peninsula during 1961–2017
Authors: Xu Lingxuan , Sun Shanlei , Chen Haishan , Chai Rongfan , Wang Jiazhi , Zhou Yang , Ma Qianrong , Chotamonsak Chakrit , Wangpakapattanawong Prasit 
Published: May 2021

AbstractGiven the key roles of the Indo–China Peninsula (ICP) in weather and climate systems, hydrometeorology, and ecology, the annual and monthly changes in the Food and Agriculture Organization‐56 Penman–Monteith reference evapotranspiration (ET0), which was calculated based on the Climatic Research Unit datasets, were investigated in ICP during 1961–2017. The annual ICP ET0 significantly (p < .05) increased, with different increasing tendencies in most months. In particular, larger and more significant (p < .05) ET0 values were found during October–December. The annual and monthly ET0 changes showed evident spatial differences, characterized by increases in more than 50% of the ICP area except for decreases in around 70% of that area during March–May. A sensitivity experiment‐based separation method was utilized to evaluate the contribution of each influential factor, and the corresponding determinants were identified by comparing the contributions. Results showed that the annual ICP ET0 increase was attributed to the increased vapour pressure deficit (Vpd). However, the annual determinants varied spatially, with net solar radiation (Rn) in the southern region of ICP, wind speed (Wnd) in the northeast, and Vpd in the remaining regions. The monthly ICP determinant was Wnd in January, March–May and December, and Vpd for the remaining months. Despite different spatial patterns of monthly dominants, Vpd and Wnd were the determinants with the most extensive distributions over ICP (>75% of ICP in total). The results of this study can significantly fulfil the research gap regarding the ICP ET0 changes and the underlying mechanisms. Meanwhile, this study provides fundamental and necessary information for protecting biodiversity and understanding hydrometeorological extreme events, thus promoting specific measures to sustain the ICP development.
The effects and mechanism of α‐mangostin on chemosensitivity of gastric cancer cells
Authors: Li Rong‐Rong , Zeng De‐Yu 
Published: May 2021

AbstractThis work investigated the effect of α‐mangostin (α‐M) on gastric cancer (GC) cell chemoresistance and its underlying mechanisms. Different concentrations of α‐M and CDDP were applied to treat GC cells (SGC7901) and CDDP‐resistant GC cells (SGC7901/CDDP) for 24 or 48 h. CCK‐8 assays were used to measure the inhibitory effect of CDDP or α‐M on SGC7901 and SGC7901/CDDP cells as well as the half‐maximal inhibitory concentrations (IC50) of α‐M for SGC7901 and SGC7901/CDDP cells. The optimal concentration and induction time of CDDP or α‐M were determined. SGC7901/CDDP cells were treated with CDDP or/and α‐M, where some of them were transfected with pcDNA3.1 or pcDNA3.1‐EBI3. Cell proliferation and apoptosis were assessed as well as the levels of EBI3, STAT3, p‐STAT3, autophagy‐related proteins, and apoptosis‐related proteins. CDDP inhibited SGC7901 cell proliferation in a dose‐dependent manner. The IC50 of α‐M for SGC7901 cells was 12.86 μM and that for SGC7901/CDDP cells was 13.69 μM. The optimal concentrations of CDDP and α‐M for SGC7901/CDDP cells were 2 and 15 μM, respectively, and the optimal time was 48 h. The SGC7901/CDDP cells in the CDDP+/α‐M+ group had elevated inhibition of proliferation and apoptosis rates. Western blot analysis revealed enhanced levels of LC3‐II/I and Beclin1, reduced p62 level, decreased Bcl2 level, and increased levels of Bax and cleaved caspase‐3/9. The EBI3/STAT3 pathway was implicated in the effect of α‐M on SGC7901/CDDP cell development. α‐M increases the chemosensitivity of GC cells by facilitating autophagy and inactivating the EBI3/STAT3 pathway.
LncRNA SNHG12 regulates the miR‐101‐3p/CUL4B axis to mediate the proliferation, migration and invasion of non‐small cell lung cancer
Authors: Xie Feng‐Wen , Liu Ji‐Chun 
Published: May 2021

AbstractMounting evidence has shown that long noncoding RNAs (lncRNAs) play critical roles in carcinogenesis and tumor progression. SNHG12 has been identified in multiple types of malignant tumors. However, the role of SNHG12 in human non‐small cell lung cancer (NSCLC) is poorly characterized, and the relevant underlying mechanism remains unclear. The expression levels of SNHG12, miR‐101‐3p, and CUL4B in collected human NSCLC tumor tissues and NSCLC cell lines were tested via qRT‐PCR. Then, NSCLC cellular proliferation, migration and invasion were determined, followed by MTT, scratch and Transwell assays. Dual‐luciferase reporter assays and RNA pulldown assays were adopted to explore the target site. Moreover, western blotting was performed to detect the relevant protein expression concerning the CUL4B/PI3K/AKT pathway. This study clarified that SNHG12 knockdown significantly reduced proliferation, migration, invasion and EMT of NSCLC cells. Our data indicated that SNHG12 targeted and negatively regulated miR‐101‐3p, and this depletion reversed the inhibitory effect of si‐SNHG12 on NSCLC cells. Furthermore, CUL4B was confirmed as a functional target of miR‐101‐3p, and its knockdown resulted in a strong alleviation of the NSLCL cell phenotype, which was enhanced by the silencing of miR‐101‐3p. Mechanistically, we found that SNHG12 regulated miR‐101‐3p to modulate the PI3K/AKT pathway mediated by CUL4B.These observations suggested that lncRNA SNHG12‐mediated miR‐101‐3p downregulation regulated the malignant phenotype of NSCLC cells by targeting CUL4B through the PI3K/AKT pathway, which may present a path to novel therapeutic strategies for NSCLC therapy.
The frustration intolerance of internet gaming disorder and its association with severity and depression
Authors: Lin Huang‐Chi , Yen Ju‐Yu , Lin Pai‐Cheng , Ko Chih‐Hung 
Published: May 2021

AbstractThis study aimed to evaluate the belief of frustration intolerance of individuals with internet gaming disorder (IGD) and its association with depression among them. We recruited 69 participants with IGD and 138 controls (69 regular gamers and other non‐gamers). IGD is diagnosed based on DSM‐5 (DSM stands for diagnostic and statistical manual of mental disorders) criteria through psychiatric interviews. They had completed the questionnaire for the belief of frustration intolerance, depression, and severity of IGD. The participant with IGD had a higher score on the frustration discomfort scale and its subscales, discomfort intolerance, entitlement, emotional intolerance, and achievement. Further regression analysis demonstrated an independent association between entitlement and IGD in control of depression. The frustration intolerance is also associated with depression and the severity of IGD among the IGD group. The discomfort intolerance and achievement were the most associated factors of depression. Frustration intolerance is a crucial irrational belief of IGD. It contributes to the severity of IGD and depression among individuals with IGD. The frustration intolerance, particularly for discomfort intolerance, entitlement, and achievement, should be assessed and intervened while treating individuals with IGD.
Gamma‐glutamyl transpeptidase elevation is associated with metabolic syndrome, hepatic steatosis, and fibrosis in patients with nonalcoholic fatty liver disease: A community‐based cross‐sectional study
Authors: Chen Li‐Wei , Huang Mi‐Sio , Shyu Yu‐Chiau , Chien Rong‐Nan 
Published: May 2021

AbstractThis study aimed to analyze the association between elevated gamma‐glutamyl transpeptidase (GGT) and metabolic syndrome (MetS), hepatic steatosis, and fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). From August 2013 to August 2018, a community‐based study was conducted in the northeastern part of Taiwan. Patients who underwent abdominal ultrasonography (US) and had no history of alcoholic liver disease were included. According to a US examination showing fatty liver degree, 1566 patients with NAFLD were divided into four groups: normal GGT, isolated GGT elevation, isolated alanine aminotransferase (ALT) elevation, and both GGT and ALT elevation groups. Further 1147 participants with normal serum ALT, GGT, and the abdominal US were included as the control group. GGT levels were associated with high sensitivity C‐reactive protein, lower adiponectin, diabetes mellitus, and chronic kidney disease. A stepwise increase in odds ratio (OR) for MetS was found in the normal GGT group (OR = 1.71), isolated GGT elevation group (OR = 3.06), isolated ALT elevation (OR = 4.00), and both GGT + ALT elevation group (OR = 4.17) than the control group. Linear regression analysis revealed a positive association between GGT/ALT value and hepatic steatosis degree, GGT value, and degree of hepatic fibrosis. Hence, GGT elevation is associated with MetS, hepatic steatosis, and fibrosis in patients with NAFLD.
“We think you may like this”: An investigation of electronic commerce personalization for privacy‐conscious consumers
Authors: Song Yong Whi (Greg) , Lim Hayoung Sally , Oh Jeeyun 
Published: May 2021

AbstractIn this study, we examine and propose a personalization technology acceptance model (TAM) for e‐commerce. We conducted a 2 (Privacy concerns priming vs. Control condition) × 2 (Personalization vs. Nonpersonalization) factorial, between‐subjects experiment among college students (Study 1, N = 205) and adult samples (Study 2, N = 211). The findings indicate consumers' perceived usefulness of personalization technology is positively related to their behavioral intentions to use an e‐commerce mobile app, supporting Davis (1989)'s TAM. Data further demonstrate that consumers' privacy concerns (i.e., Study 1) and willingness to self‐disclose (i.e., Study 2) moderate the personalization–behavioral intention relationship. Overall, the efficacious operation of personalization technology in e‐commerce depends on the usefulness and precision of personalized recommendations as well as consumers' privacy concerns and preferences in trading off personal information.
Alleviating the toxicity concerns of antibacterial cinnamon‐polycaprolactone biomaterials for healthcare‐related biomedical applications
Authors: Ahmed Jubair , Gultekinoglu Merve , Bayram Cem , Kart Didem , Ulubayram Kezban , Edirisinghe Mohan 
Published: May 2021

AbstractFibrous constructs with incorporated cinnamon‐extract have previously been shown to have potent antifungal abilities. The question remains to whether these constructs are useful in the prevention of bacterial infections in fiber form and what the antimicrobial effects means in terms of toxicity to the native physiological cells. In this work, cinnamon extract containing poly (ε‐caprolactone) (PCL) fibers were successfully manufactured by pressurized gyration and had an average size of ∼2 μm. Cinnamon extract containing PCL fibers were tested against Escherichia coli, Staphylococcus aureus, Methicillin resistant staphylococcus aureus, and Enterococcus faecalis bacterial species to assess their antibacterial capacity; it was found that these fibers were able to reduce viable cell numbers of the bacterial species up to two orders of magnitude lower than the control group. The results of the antibacterial tests were assessed by scanning electron microscopy (SEM). The constructs were also tested under indirect MTT tests where they showed little to no toxicity, similar to the control groups. Additionally, cell viability fluorescent imaging displayed no significant toxicity issues with the fibers, even at their highest tested concentration. Here we present a viable method for the production the non‐toxic and naturally abundant cinnamon extracted fibers for numerous biomedical applications.
Individual risk prediction of urinary incontinence after prostatectomy and impact on treatment choice in patients with localized prostate cancer
Authors: Tillier Corinne N. , Vromans Ruben D. , Boekhout Annelies H. , Veerman Hans , Wollersheim Barbara M. , van Muilekom Henricus A. M. , Boellaard Thierry N. , van Leeuwen Pim J. , van de Poll‐Franse Lonneke V. , van der Poel Henk G. 
Published: May 2021

AbstractAimsIndividualized information about the risk of incontinence after prostatectomy could help patients in shared decision‐making.MethodsWe compared a historical control cohort (n = 254; between June 2016 and 2017) that received standardized information about the risk of incontinence after robot‐assisted radical prostatectomy (RARP) with a prospective patient cohort (n = 254; between June 2017 and May 2018) that received individualized information of the chance of recovery of incontinence within 6 months postoperatively based on the continence prediction tool (CPRED). We measured switch in treatment choice, health‐related quality of life (QoL) in both cohorts and the accuracy of the CPRED tool.ResultsPatients in the individualized information group with RARP as initial preference switched more often to another treatment than patients who received standardized information (16% vs. 5%; p = 0.001). Patients in the individualized information group with a high risk of incontinence and with RARP as initial preference switched more often to other treatments than patients in intermediate/low risk of incontinence (35% vs. 9.8%; p = 0.001). Patients with a low risk of incontinence choosing RARP after individualized information were less likely to use more than one diaper a day at any time postoperative (p = 0.001) compared to men with an intermediate/high incontinence risk. Overall QoL was worse in patients with incontinence than patients with continence 6 and 12 months after RARP (respectively; p < 0.0001 and p = 0.007).ConclusionPersonalized information about the risk of incontinence after RARP makes more patients reconsidering their initial treatment preference. The CPRED correlated strongly with continence outcome after RARP and is a useful tool for shared decision‐making.
Childbirth experience and practice changing during COVID‐19 pandemic: A cross‐sectional study
Authors: Inversetti Annalisa , Fumagalli Simona , Nespoli Antonella , Antolini Laura , Mussi Serena , Ferrari Debora , Locatelli Anna 
Published: May 2021

AbstractAimTo evaluate mothers’ satisfaction with childbirth experience in a cohort of women who delivered during COVID pandemia and to compare them to a pre‐COVID cohort.DesignWe performed a cross‐sectional study in a low‐risk Maternity Unit.MethodsWomen who delivered during COVID‐19 pandemic were compared to a pre‐COVID cohort recruited in 2018 in the same setting. Italian version of the Birth Satisfaction Scale‐Revised (I‐BSS‐R) was used.ResultsThree hundred and seventy‐seven women were included (277 pre‐COVID and 100 during COVID pandemic). No differences in terms of satisfaction at birth were reported (I‐BSS‐R mean 27.0, SD 5.3 versus mean 27.6, SD 6.1, p 0.34), despite an increased rate of active intrapartum interventions. Intrapartum variables that significantly reduced satisfaction were the same in the two groups: epidural analgesia (p < .0001 in both groups), prolonged active phases (p < .0001 in both), oxytocin administration (p < .0001 in both) and operative delivery (p 0.0009 versus p 0.0019).
Risk factors for low self‐care self‐efficacy in cancer survivors: Application of latent profile analysis
Authors: Huang Qingmei , Wu Fulei , Zhang Wen , Stinson Jennifer , Yang Yang , Yuan Changrong 
Published: May 2021

AbstractAimTo identify subgroups of cancer patients with distinct self‐care self‐efficacy profiles and to explore factors that can be used to predict those at risk of low self‐efficacy.DesignA secondary analysis of data pooled from two cross‐sectional surveys was performed.MethodsIn total, 1,367 Chinese cancer survivors were included in the analysis. Latent profile analysis (LPA) was performed to categorize participants into latent subgroups with distinct self‐efficacy profiles. Multinomial logistic regression was conducted to identify predictors of self‐care self‐efficacy subgroup classification.ResultsWe identified three distinct subgroups: low, medium and high self‐care self‐efficacy. Patients with the “low” profile, which was characterized by a low education level, single marital status, complications, late cancer stage and a lower level of social support, had the poorest self‐care behaviour.
Succinate Dehydrogenase-Deficient Renal Cancer Featuring Fructose-1,6-Biphosphatase Loss, Pyruvate Kinase M2 Overexpression, and SWI/SNF Chromatin Remodeling Complex Aberrations: A Rare Case Report
Authors: Szymanski Michal , Rusetska Natalia , Jancewicz Iga , Armatowska Alicja , Ligaj Marcin , Chrzan Alicja , Hincza Kinga , Kowalik Artur , Mika Pawel , Kisiel Maciej , Zolnierek Jakub , Kosior Joanna , Demkow Tomasz , Siedlecki Janusz A. , Sarnowski Tomasz J. , Sarnowska Elzbieta 
Published: May 2021

Abstract

Succinate dehydrogenase (SDH)-deficient renal cancer is a rare renal cancer subtype recently accepted by the World Health Organization as a unique subtype of renal cell carcinoma (RCC). Here we report a case of 17-year-old man. The detailed evaluation indicated occurrence of the SDHB-deficient RCC. The genetic testing revealed no germline mutation in SDH genes. Immunohistochemistry showed SDHB deficiency, overexpression of pyruvate kinase M2 and dramatic downregulation of fructose-1,6-bisphosphatase metabolic enzymes, and unaltered levels of phosphorylated AMP-activated protein kinase and mammalian target of rapamycin. Strong upregulation of INI1 and BRG1 and overexpression of BAF180, subunits of SWI/SNF ATP-dependent chromatin remodeling complex, were also found. The identified tumor pathologically did not resemble clear cell renal cell carcinoma (ccRCC), but some metabolic alterations are common for both cancer types. Thus, we postulate that the phenotypical differences between ccRCC and SDHB-deficient RCC may be related to distinct molecular and metabolic alterations.

Implications for Practice
Succinate dehydrogenase (SDH)-deficient renal cell carcinoma (RCC) is a rare renal tumor occurring even in young patients. Until now, in all described and genetically tested cases, mutations and deletions in SDH genes have been found. This article describes SDHB-deficient RCC without any germline mutations in SDH genes. Therefore, genetic analysis for germline mutations in SDH genes in SDH-deficient RCC, especially in young individuals, should be strongly recommended, although as of now it is not obligatory. This knowledge will allow improvement of patient monitoring including both disease recurrence and new cancer appearance.
Development and initial evaluation of the ICD‐11 personality disorder severity scale: PDS‐ICD‐11
Authors: Bach Bo , Brown Tiffany A. , Mulder Roger T. , Newton‐Howes Giles , Simonsen Erik , Sellbom Martin 
Published: May 2021

AbstractAimNo measure has formally been developed to assess the published ICD‐11 model of Personality Disorder (PD) severity. We therefore set out to develop and evaluate the 14‐item Personality Disorder Severity ICD‐11 (PDS‐ICD‐11) scale.MethodA representative U.S. community sample (N = 428; 50.9% women) and a New Zealand mental health sample (N = 87; 61.5% women) completed the PDS‐ICD‐11 scale along with a series of established PD and impairment measures.ResultsItem response theory supported the unidimensionality of PDS‐ICD‐11 (median item loading of 0.68) and indicated that a PDS‐ICD‐11 score of 17.5 may serve as a benchmark for pronounced dysfunction. Correlation and regression analyses supported both criterion validity and incremental validity in predicting impairment and PD symptoms. The PDS‐ICD‐11 was particularly associated with measures of Level of Personality Functioning Scale (LPFS), Global PD severity, and Borderline PD symptom score. A comparison between clinical individuals diagnosed with an ICD‐11 PD vs. no PD supported diagnostic validity.ConclusionThis initial construction study suggests that the PDS‐ICD‐11 constitutes a promising instrument that provides a quick impression of the severity of personality dysfunction according to the official ICD‐11 PD guidelines. Clearly, more research is needed to corroborate its validity and utility. The PDS‐ICD‐11 scale is provided as online supporting information.
Pneumothorax prevalence and mortality per gestational age in the newborn
Authors: Acun Ceyda , Nusairat Leen , Kadri Amer , Nusairat Aseel , Yeaney Natalie , Abu−Shaweesh Jalal , Aly Hany 
Published: May 2021

AbstractObjectivesPneumothorax (PTX) in newborns is a life‐threatening condition associated with high morbidity and mortality especially in premature infants. The frequency of PTX in neonates at different gestational ages (GA) and its impact on neonatal mortality have not been quantified. We aimed to determine: (1) the prevalence of PTX in neonates at different GA from ≤24 to ≥37 weeks, (2) the impact of PTX on mortality per GA, and (3) the impact of PTX on the length of stay (LOS) per GA.MethodsThe national Kids' Inpatient Database for the years of 2006–2012 were used. We included all infants admitted to the hospital with a documented GA and International Classification of Disease 9 code of PTX. Bivariate and multivariate analyses were conducted and odds ratios (OR) were calculated.ResultsA total of 10,625,036 infants were included; of them 3665 infants (0.034%) had a diagnosis of PTX, with highest prevalence at ≤24 weeks GA (0.67%), and lowest at term (0.02%). The overall mortality rate of patients with PTX was 8.8%, and greater in preterm (16.3%) versus term infants (2.7%). The association of mortality with PTX was greatest at GA of 29–32 weeks (OR = 8.55; 95% confidence interval: 6.56–11.13). Infants who survived until discharge had a median of 2–12 days longer LOS depending on GA category.ConclusionsThe prevalence of PTX peaks in infants less than 24 weeks, however, its impact on mortality is greatest at 29–32 weeks. PTX is associated with longer LOS in survivors.
Morbidity and respiratory outcomes in infants requiring tracheostomy for severe bronchopulmonary dysplasia
Authors: House Melissa , Nathan Amy , Bhuiyan Mohammad A. N. , Ahlfeld Shawn K. 
Published: May 2021

AbstractObjectiveThe decision for tracheostomy for bronchopulmonary dysplasia (BPD) is highly variable and often dictated by local practice. We aimed to characterize morbidity, mortality, and respiratory outcomes in preterm infants undergoing tracheostomy for severe BPD.Study DesignWe retrospectively reviewed a single‐center 4‐year cohort of all infants born <33 weeks gestational age (GA) that required tracheostomy due to severe BPD. Indications for tracheostomy apart from BPD were excluded. Demographic information, comorbidities, respiratory management, age at tracheostomy, post‐discharge respiratory outcomes, and survival were examined up to at least 5 years of age.ResultsAt a mean corrected GA of 43.3 weeks, 49 preterm infants with severe BPD required tracheostomy. Forty‐six infants (94%) had long‐term follow‐up. Compared to survivors, the 12 (26.1%) infants that died were significantly more likely to be small for gestational age (SGA) or require treatment for pulmonary hypertension. GA, birth weight, sex, antenatal corticosteroid exposure, need for patent ductus arteriosus ligation, and magnitude of respiratory support at tracheostomy placement were not associated with mortality. At the latest follow‐up, 97% were liberated from mechanical ventilation and 79% decannulated. Morbidities of the upper airway were common, and 13/27 (47%) decannulated infants had required airway reconstruction.ConclusionPreterm infants undergoing tracheostomy experienced significant mortality, particularly those who were SGA or had pulmonary hypertension. However, by 5 years of age, most infants liberalized from mechanical ventilation and decannulated. Magnitude of respiratory support at time of tracheostomy was not associated with mortality and should not deter intervention. Nearly half of patients required airway reconstruction before decannulation.