bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 2-order Additive Fuzzy Measure Identification Method Based on Hesitant Fuzzy Linguistic Interaction Degree and Its Application in Credit Assessment
Authors: Zhang Mu , Cao Cheng 
Published: April 2021

Abstract
In order to solve the problem that it is difficult to quantitatively evaluate the interactivity between attributes in the identification process of 2-order additive fuzzy measure, this work uses the hesitant fuzzy linguistic term set (HFLTS) to describe and deal with the interactivity between attributes. Firstly, the interactivity between attributes is defined by the supermodular game theory, and a linguistic term set is then established to characterize the interactivity between attributes. Secondly, under the linguistic term set, according to the above definition, the experts employ the linguistic expressions generated by the context-free grammar to evaluate the interactivity between attributes, and the opinions of all experts are then aggregated by using the defined hesitant fuzzy linguistic weighted power average operator (HFLWPA). Thirdly, based on the standard Euclidean distance formula of the hesitant fuzzy linguistic elements (HFLEs), the hesitant fuzzy linguistic interaction degree (HFLID) between attributes is defined and calculated by constructing a piecewise function. Finally, a 2-order additive fuzzy measure identification method based on HFLID is further proposed. Based on the proposed method, using the Choquet fuzzy integral as nonlinear integration operator, a multi-attribute decision making (MADM) process is presented. Taking the credit assessment of the big data listed companies in China as an application example, the feasibility and effectiveness of the proposed method is verified by the analysis results of application example.
R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability
Authors: Mosler Thorsten , Conte Francesca , Mikicic Ivan , Kreim Nastasja , Möckel Martin , Flach Johanna , Luke Brian , Beli Petra 
Published: April 2021

Abstract
Transcription can pose a threat to genomic stability through the formation of R-loops that obstruct the progression of replication forks. R-loops are three-stranded nucleic acid structures formed by an RNA-DNA hybrid with a displaced non-template DNA strand. We developed RDProx to identify proteins that regulate R-loops in human cells. RDProx relies on the expression of the hybrid-binding domain (HBD) of Ribonuclease H1 (RNaseH1) fused to the ascorbate peroxidase (APEX2) and permits mapping of the R-loop proximal proteome using quantitative mass spectrometry. We implicate different cellular proteins in R-loop regulation and identify a role of the tumor suppressor DEAD box protein 41 (DDX41) in opposing R-loop-dependent genomic instability. Depletion of DDX41 resulted in replication stress, double strand breaks and inflammatory signaling. DDX41 opposes the accumulation of R-loops by unwinding RNA-DNA hybrids at gene promoters and its loss leads to upregulation of TGFβ and NOTCH signaling genes. Germline loss-of-function mutations in DDX41 lead to predisposition to acute myeloid leukemia (AML) in adulthood. We propose that accumulation of R-loops at CpG island promoters, altered TGFβ and NOTCH signaling, and inflammatory response contribute to the development of familial AML with mutated DDX41.
A Validation Procedure for Landscape Connectivity Approaches: Evaluation of The Accuracy of Ecological Corridor Locations.
Authors: Lalechère Etienne , Bergès Laurent 
Published: April 2021

Abstract
ContextConnectivity conservation analysis is based on a wide range of approaches designed to locate key ecological corridors in order to maintain multispecies flows. However, the lack of validation procedures with accessible data prevents from selecting the most accurate approach.ObjectivesWe propose a new validation procedure to evaluate the accuracy of ecological corridor locations in landscape connectivity approaches. We applied this procedure to compare three modelling approaches and select the most accurate. MethodsOur procedure validates ecological corridor tracks with independent presence-only data, under the hypothesis that species should be present within or near the corridors (according to resistance distance) if the corridors have been correctly modelled. We applied Maxent and circuit theory to locate ecological corridors for forest bird species in a rural landscape following three approaches based on land cover, umbrella species and multispecies presence data. We compared the proportion of overlaid corridors among the three approaches, and selected the most accurate one according to our validation index.ResultsThe corridors modelled from species presence data (umbrella and multispecies approaches) were more consistent than the habitat-based (land cover) approach. The multispecies approach was the most accurate while habitat approach was the least accurate in locating ecological corridors.ConclusionsOur procedure can be used to: (1) evaluate the accuracy of the location of ecological corridors, (2) select the best approach to locate ecological corridors, and (3) validate the underlying assumptions of landscape connectivity approaches (e.g. dispersal and matrix resistance values).
Rh immune globulin: an interfering substance in compatibility testing
Authors: Casina T.S. , Sandler S.G. , Autenrieth S.M. 
Published: April 2021

Abstract
Immunoglobulin therapy that interferes with pretransfusion testing may complicate the interpretation of test results and adversely affect patient management. Rh immune globulin (RhIG) should be considered an interfering immunoglobulin therapy when it is detected in an antibody detection test of a sample from a patient who has been treated with RhIG. Frequently, detection occurs in mother’s or newborn’s plasma. Because an antenatal injection of RhIG is indicated for pregnant Rh-negative women, anti-D is detected frequently by today’s highly sensitive antibody screen methods when the mother’s plasma is tested subsequently at delivery. Ascertaining the source of anti-D is complicated by the inability of routine clinical laboratory methods to distinguish anti-D due to RhIG from alloimmune anti-D. A combination of qualitative and quantitative test methods, as well as a complete clinical history, is necessary for accurate diagnosis and patient management.
A case of platelet transfusion refractoriness due to anti-CD36 with a successful treatment outcome
Authors: Khatri S.S. , Curtis B.R , Yamada C. 
Published: April 2021

Abstract
Antibodies (Abs) against antigens on platelets (PLTs), including glycoprotein IV (CD36), can cause PLT refractoriness. Transfusing PLTs to patients with anti-CD36 is challenging because of the rarity of CD36-negative (CD36–) donors and the possibility of additional HLA Abs. We report a case of PLT refractoriness due to anti-CD36 and HLA Abs. A 21-year-old man (group O, D+) with assumed drug-induced aplastic anemia received multiple PLT transfusions and developed severe PLT refractoriness. He was found to have anti-CD36 as well as HLA class I Abs, with a CD36– phenotype on both PLTs and monocytes. He was diagnosed with type 1 CD36 deficiency and received intravenous immunoglobulin (IVIG) and rituximab to decrease future Ab production. The PLT corrected count increment (CCI) improved significantly with subsequent transfusions of flow crossmatch-compatible as well as uncrossmatched PLTs. He eventually received a bone marrow transplant and has been doing well since. The mean CCI before and after IVIG/rituximab treatment was 0.2 and 6.2, respectively. Soon after IVIG started, the patient’s CCI after receiving CD36–, group AB, D+, and HLA untested PLTs was 0.8, but his CCI after receiving flow crossmatch-compatible PLTs was 12.6. Two months after IVIG was started, the mean CCIs for uncrossmatched apheresis PLTs and crossmatch-compatible PLTs were comparable (6.1 versus 6.0, respectively). Desensitization treatment with IVIG and rituximab lowered anti-CD36 and HLA Ab levels, and the CCI of PLT transfusion improved significantly. This case demonstrates that immune suppression is effective for successful PLT transfusion of patients with anti-CD36.
Comparison of ABO genotyping methods: a study of two low-resolution polymerase chain reaction assays in a clinical testing laboratory
Authors: Keller J.A. , Horn T. , Scholz S. , Koenig S. , Keller M.A. 
Published: April 2021

Abstract
The ABO blood group system is the most clinically significant system in transfusion medicine. Although serologic typing for ABO antigens is routine and reliable, molecular methods can be used to predict an ABO type in the absence of a blood specimen as well as to investigate ABO typing discrepancies often caused by ABO subgroups that cause weakened antigen expression, weak or missing serum reactivity, and/or extra red blood cell reactivity. By detecting single nucleotide variants that are hallmarks of the major ABO alleles, low-resolution genotyping methods can be used to make allele assignments and predict phenotypes. This approach has become a dependable tool, initially to resolve typing discrepancies identified in blood banks and donor centers and, more recently, to predict the ABO group in bone marrow transplant donors and in deceased donors of solid organs. The aim of this report is to compare two different low-resolution polymerase chain reaction (PCR)-based methods: a PCR-restriction fragment length polymorphism (RFLP) implemented based on a publication and a commercially available TaqMan-based sequence-specific primer-PCR for resolution of ABO typing discrepancies. Fifty-six peripheral blood samples from 31 patients and 25 blood donors were used to isolate genomic DNA and perform genotyping. Results of 49 of the 56 samples (87.5%) were concordant between methods, three samples yielded an unexpected banding pattern on the PCR-RFLP method, and four sample results were discordant between assays. The discordances all involved group A versus A2 discrepancies. Sanger sequencing was used as a high-resolution genotyping method to resolve discrepancies between the two low-resolution methods. This study demonstrates that, in the majority of cases, a low-resolution genotyping method can resolve an ABO discrepancy. Although there is no U.S. Food and Drug Administration–approved genotyping method for ABO determination, molecular testing for investigation of discrepancies is a useful tool for blood banks and transplant programs.
Saline–indirect antiglobulin test
Authors: Hamilton J.R. 
Published: April 2021

Abstract
A saline–indirect antiglobulin test (IAT) is performed without addition of enhancement media to increase the binding of antibody to the red blood cell antigen during the 37°C incubation. Although infrequently used as a primary means for antibody detection or identification, this test is useful because of the variety of possible applications in antibody identification studies. It is critical to the test sensitivity to allow enough incubation time (30–60 minutes) for maximum antibody binding to occur. The saline test can also be subject to a direct agglutination reading after immediate spin, room temperature, or incubation at 37°C before conversion to the IAT. This step allows further flexibility in assessing the reactivity of directly agglutinating allo- or autoantibodies in tests performed at 37°C or lower temperatures.
Severe hemolytic disease of the fetus and newborn due to anti-E and anti-Jka
Authors: Mandal S. , Malhotra S. , Negi G. , Tiwari A. , Mitra S. , Basu S. , Singh P. 
Published: April 2021

Abstract
Red blood cell alloimmunization to antigens other than D, such as C, c, E, e, and antigens in the Kell, MNS, and Duffy blood group systems, has emerged as an important cause of hemolytic disease of the fetus and newborn (HDFN). Antibody screening for these antibodies is not routinely practiced for all antenatal patients in developing countries, mainly because of financial constraints. Here we report a rare case of HDFN due to dual antibodies to Rh and Kidd blood group system antigens: anti-E and anti-Jka. This case report highlights the importance of routine and regular antenatal screening of all pregnant women for proper monitoring and follow-up.
Prediction of runoff in the upper Yangtze River based on CEEMDAN-NAR model
Authors: Zhang Xianqi , Zheng Zhiwen , Wang Kai 
Published: April 2021

Abstract
Scientific and accurate prediction of river runoff is important for river flood control and sustainable use of water resources. This study evaluates the ability of a Nonlinear Auto Regressive model (NAR) in predicting runoff volume. Using the Cuntan Hydrological Station in the upper reaches of the Yangtze River as the research object, the model was established based on the runoff characteristics from 1951 to 2020 and tested by NAR. To improve the prediction efficiency, complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN) preprocessing technique is used to decompose the data. The results show that the coupled CEEMDAN-NAR model has better predictive ability than the single model, with a coupled model deterministic coefficient (DC) of 0.93 and a prediction accuracy of Class A.
Анализ распространения видов Сandida, выделенных у женщин с кандидозным вульвовагинитом, и профили их чувствительности к противогрибковым препаратам
Authors: Burduniuc O.S. , Bîrcă E.I. , Burduniuc A.M. , Bivol M.V. , Iacon O.S. 
Published: April 2021

Актуальность. Обычно виды Candida - это комменсальный грибок, обитающий во влагалище примерно 30–50% здоровых взрослых женщин, который является наиболее частым возбудителем, выделенным из клинических образцов пациенток с диагнозом вульвовагинальный кандидоз (ВВК). Культуральный метод не рекомендуется для всех пациентов на регулярной основе, но он информативен для исключения non-albicans инфекций, устойчивых к азолам, или рецидивов ВВК. Определение видов Candida и тестирование на чувствительность к противогрибковым препаратам являются ключевыми элементами в правильном ведении рецидивирующего ВВК. Авторы данной статьи ставили перед собой цель изучить спектр патогенных видов Candida. Также представлена картина противогрибковой чувствительности выделенных штаммов за 2017-2019 годы. Материалы и методы. Проведено описательное исследование распространения видов Candida и их чувствительности к противогрибковым препаратам. Идентификацию изолированных видов Candida проводили с помощью MALDI-TOF масс-спектрометрии, штаммов – с помощью автоматизированной системы Vitek 2 (BioMérieux), а профили противогрибковой чувствительности - с помощью Fungitest (Bio-Rad). Результаты. Из 1030 обработанных штаммов преобладали виды C. albicans – 83,8 %, Candida non-albicans – 16,2 %. Наиболее распространенным видом Candida non-albicans была C.glabrata (7,5 %). Также было замечено, что в 56,6 % случаев C. albicans представляла часть бактериальной ассоциации. Наиболее частыми микробными ассоциациями были C. albicans и S.aureus (26,6 %), затем следовали C. albicans и E.coli (20,8 %). Виды Candida показали умеренную устойчивость к противогрибковым препаратам. Уровень устойчивости изолятов C. albicans к миконазолу, флуконазолу и итраконазолу составлял 25,5 %, 17,0 % и 11,4 % соответственно, по сравнению со штаммами Candida non-albicans, которые показали уровень устойчивости 10,8 %, 14,4 % и 10 % соответственно. Выводы. C. albicans является наиболее часто изолированным видом среди пациенток с ВВК, но также наблюдается повышенная доля видов Candida non-albicans, таких как C. glabrata. Изоляты C. albicans показали более высокие показатели лекарственной устойчивости, чем Candida non-albicans.
AGROINDUSTRIALISASI KOPI ARABIKA JAVA PREANGER DI DESA MARGAMULYA KECAMATAN PANGALENGAN KABUPATEN BANDUNG
Authors: Djuwendah Endah , Karyani Tuti , Sadeli Agriani H , Kusno Kuswarini 
Published: April 2021

ABSTRAKKopi merupakan salah satu komoditas perkebunan unggulan yang sudah lama dibudidayakan. Selain berperan dalam penyerapan tenga kerja, Kopi menjadi komoditas ekspor yang bernilai ekonomi tinggi. Kopi terbaik dari Jawa Barat dikenal dunia internasional sebagai Java Preanger kopi. Kecamatan Pangalengan Kabupaten bandung merupakan salah satu sentra produksi kopi Java preanger yang potensial karena selain terdapat perkebunan kopi di wilayah ini juga berkembang industri pengolahannya. Tujuan dari penelitian ini adalah untuk mengetahui dinamika perkembangan agroindustri Java Preager Coffee di Desa Margamulya Kecamatan Pangalengan Kabupaten Bandung. Penelitian ini dilakukan dengan menggunakan desain deskriptif kualitatif dan teknis penelitin studi kasus. Pegumpulan data menggunakan metode observasi, wawancara dan studi literatur. Hasil penelitian menunjukkan bahwa proses agroindustri Java preager coffee yang terdapat di Kecamatan Pangalengan Bandung sudah berjalan dengan baik. Ini terbukti dari adanya perubahan yang terjadi dalam : (1) pertumbuhan dari pelaku usahtani, pengolahan hasil pertanian, distribusi dan input pertanian, (2) perubahan kelembagaan dan keorganisasian dalam hubungannya dengan perusahaan melalui peningkatan koordinasi vertikal dan perubahan dalam komposisi produk, teknologi, perwilayahan dan struktur pasar serta (4) peningkatan nilai tambah.Kata kunci : Agroindustrialisasi, kopi arabica, Java preangerABSTRACTCoffee is one of the leading plantation commodities that has long been cultivated. In addition to playing a role in the absorption of work, coffee is a high-value export commodity. The best coffee from West Java is known internationally as Java Preanger coffee. Pangalengan District, Bandung regency is one of the potential Java preanger coffee production centers because in addition to coffee plantations in the region, the processing industry is also developing. The purpose of this study was to determine the dynamics of the development of Java Preager Coffee agroindustry in Margamulya Village, Pangalengan District, Bandung Regency. This research was conducted using descriptive qualitative design and technical research case studies. Collect data using the method of observation, interviews and literature studies. The results showed that the Java preager coffee agroindustry process in Pangalengan District of Bandung had gone well. This is evident from the changes that occur in: (1) growth of business actors, agricultural product processing, agricultural distribution and input, (2) institutional and organizational changes in their relationship with companies through increased vertical coordination and changes in product composition, technology, territories and market structure and (4) increase in added value.Keywords: Agroindustrialization, arabica coffee, Java preanger
PEMBERDAYAAN UMKM BERBASIS EKONOMI KREATIF DI PESISIR PANTAI CIMALAYA – SUBANG JAWA BARAT
Authors: Hanidah In-In - , Mulyono Agung Tri , Moody Sumanti Debby , Aprilani Renita Dwi , Setiasih Imas Siti 
Published: April 2021

ABSTRAKPengembangan UMKM Abon Ikan Tengkek mempunyai peranan yang sangat penting untuk pertumbuhan ekonomi bagi masyarakat Desa Cilamaya Hilir Kabupaten Subang. Penerapan ekonomi kreatif merupakan konsep pengembangan ekonomi pelaku UMKM Abon Ikan Tengkek untuk meningkatkan nilai tambah produk dengan menciptakan produk melalui perbaikan proses produksi, penerapan GMP, perbaikan desain kemasan, peningkatan legalitas usaha, dan perluasan pemasaran. Metode kajian yang dilakukan terdiri dari: observasi, wawancara, persuasif, dan andragogi untuk mengoptimalkan tujuan penelitian. Hasil kajian menunjukkan pemberdayaan UMKM Abon Ikan Tengkek berbasis ekonomi kreatif mampu meningkatkan penjualan sebesar 81,25%/tahun. Kata Kunci: UMKM, abon, ikan tengkek, ekonomi kreatifABSTRACTSmall and medium-sized enterprises (SMEs) development of "Abon Ikan Tengkek" has a very important role for economic growth for the people of Cilamaya Hilir Village - Subang. The application of the creative economy is the concept businessmen of "Abon Ikan Tengkek" SMEs to increase product added value by creating products through improving production processes, implementing GMP, improving packaging design, improving business legality, and expanding marketing. The method of study conducted consists of: observation, interview, persuasive, and andragogy to optimize the research objectives. The results of the study showed that the empowerment "Abon Ikan Tengkek" SMEs based on creative economy was able to increase sales by 81.25%/year.Keywords: SMEs, abon, tengkek fish, creative economy
Strategi Pengembangan Benih Bawang Putih di Kecamatan Agrapura Kabupaten Majalengka
Authors: Pardian Pandi , Noor Trisna Insan 
Published: April 2021

Abstrak Kabupaten Majalengka telah lama dikenal sebagai salah satu sentra bawang merah, selain bawang merah ternyata produksi bawang putih juga dilakukan di Kabupaten Majalengka. Salah satu kegiatan yang dilakukan pemerintah untuk mendukung produksi bawang putih di Kabupaten Majalengka adaalh dengan membuat program mengembangkan sistem produksi perbenihan bawang putih untuk mendukung produksi benih bawang secara kontinu dan berkualitas, sehingga hasil produksi bawang putih lebih baik dan berkembang. Program pengebangan benih bawang putih kerjasama dengan importir dari benih yang didatangkan oleh impotir tenyata memiliki beberapa permasalahan utama diantaranya tidak berumbi. Hal tersebut menarik peneliti untuk melakukan penelitian terkait strategi pengembangan benih bawang putih di Kabupaten Majalengka. Penelitian ini menggunakan metode survey sedangkan untuk mengetahui strategi pengembangan benih bawang putih dengnan alat analisis AHP (Analitycal Hierarchy Process). Sedangkan data yang dipergunakan dalam penelitian adalah data primer dan sekunder. Data primer didapatkan dari survey, sedangkan data sekunder diperoleh dari pencatatan/keterangan dari instansi terkait serta laporan hasil penelitian terdahulu. Hasil penelitian ini menunjukkan bahwa alternative strategi pengembangan benih bawang putih adalah melakukan kerjasaa dengn petani atau kelompok tani dengan penggunaan dan kesiapan teknologi budidaya serta jaminan pasar hasil produksi benih.Kata Kunci : Bawang Putih, Benih, Analytical Hierarchy Proces , Majalengka.AbstractMajalengka Regency has been known as one of the centers of shallots. Besides shallots, in Majalengka Regency also it turns out garlic production. One of the activities carried out by the government to support garlic production in Majalengka Regency is creating a program to develop a production system for garlic seedlings to support continuous and quality production of onion seeds, so that garlic production is better and growing. The garlic seed development program in cooperation with importers has several main problems including non-tuber. This attracted researchers to conduct research related to the strategy of developing garlic seeds in Majalengka Regency. This study uses a survey method while to determine the strategy of developing garlic seeds with AHP (Analytical Hierarchy Proces). This study uses primary and secondary data. Primary data is obtained from surveys, while secondary data is obtained from recording/ information from relevant agencies and reports on previous research results. The study results indicate that the alternative strategy for developing garlic seeds is to collaborate with farmers or farmer groups with the use cultivation technology and market guaranteed for the seeds production.Keywords: Garlic, Seeds, Analytical Hierarchy Proces, Majalengka.