bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two leading international congresses in Iran in the era of COVID‐19: 21st royan international twin congress, 4th international and 16th Iranian genetics congress
Authors: Montazeri Leila , Mohajeri Maryam , Baharvand Hossein , Fathi Rouhollah , Poli Valeria , Kazemi Sara , Pahlavan Fattaneh , Kouhestani Solmaz , Ahmadi Firoozeh , Mowla Seyed Javad 
Published: April 2021

AbstractIn this report, we look at the challenges posed by the outbreak of COVID‐19 and how the Executive Board of these two congresses succeeded in overcoming those challenges and holding two congresses. The approach for a large festival with different virtual setting components provided a suitable solution that led to exemplary achievements and created an appropriate model for future virtual or combined virtual and face‐to‐face events. These events proved that pandemic problems could not limit the organizers, pushing them to make better use of the facilities and turning this threat into an opportunity.
Targeting stanniocalcin‐1‐expressing tumor cells elicits efficient antitumor effects in a mouse model of human lung cancer
Authors: Abe Kotaro , Kanehira Masahiko , Ohkouchi Shinya , Kumata Sakiko , Suzuki Yamato , Oishi Hisashi , Noda Masafumi , Sakurada Akira , Miyauchi Eisaku , Fujiwara Tohru , Harigae Hideo , Okada Yoshinori 
Published: April 2021

AbstractLung cancer is the most common cause of cancer‐related death in developed countries; therefore, the generation of effective targeted therapeutic regimens is essential. Recently, gene therapy approaches toward malignant cells have emerged as attractive molecular therapeutics. Previous studies have indicated that stanniocalcin‐1 (STC‐1), a hormone involved in calcium and phosphate homeostasis, positively regulates proliferation, apoptosis resistance, and glucose metabolism in lung cancer cell lines. In this study, we investigated if targeting STC‐1 in tumor cells could be a promising strategy for lung cancer gene therapy. We confirmed that STC‐1 levels in peripheral blood were higher in lung cancer patients than in healthy donors and that STC‐1 expression was observed in five out of eight lung cancer cell lines. A vector expressing a suicide gene, uracil phosphoribosyltransferase (UPRT), under the control of the STC‐1 promoter, was constructed (pPSTC‐1‐UPRT) and transfected into three STC‐1‐positive cell lines, PC‐9, A549, and H1299. When stably transfected, we observed significant cell growth inhibition using 5‐fluorouracil (5‐FU) treatment. Furthermore, growth of the STC‐1‐negative lung cancer cell line, LK‐2 was significantly arrested when combined with STC‐1‐positive cells transfected with pPSTC‐1‐UPRT.We believe that conferring cytotoxicity in STC‐1‐positive lung cancer cells using a suicide gene may be a useful therapeutic strategy for lung cancer.
Effect of body mass index on pharmacokinetics of paclitaxel in patients with early breast cancer
Authors: Gota Vikram , Nookala Manjunath , Bonda Avinash , Karanam Ashwin , Shriyan Bharati , Kembhavi Yogesh , Gurjar Murari , Patil Anand , Singh Ashish , Goyal Navin , Gupta Sudeep 
Published: April 2021

ABSTRACTBackgroundPaclitaxel is dosed according to body surface area (BSA) but there is scant information on actual drug exposure in overweight and obese patients.MethodsEarly breast cancer patients receiving paclitaxel at 175 mg/m2 every 3 weeks, in two BMI groups (normal, 18–24.9 kg/m2 and overweight/obese, ≥25 kg/m2, respectively), matched for age, serum albumin and bilirubin levels using minimization technique, were included. Sparse pharmacokinetic (PK) sampling was performed at 7 time points from 0 h until 24 h of starting paclitaxel in cycle 1. Paclitaxel concentration was measured using a validated LCMS/MS method. Covariate effect on paclitaxel PK was evaluated by population PK analysis using NONMEM software.ResultsEighteen female patients each were enrolled in normal and overweight groups with mean BMI of 21.62 ± 2.06 and 28.16 ± 2.31 kg/m2, mean BSA of 1.44 ± 0.11 and 1.69 ± 0.14 m2 and mean paclitaxel dose of 250 ± 18 and 293 ± 21 mg, respectively. Model predicted AUC and dose normalized AUC (mean ±SD) in the normal BMI versus overweight obese groups were 23 ± 11.0 µmol*h/L versus 25.7 ± 13.7 µmol*h/L (two‐sample t‐test p > 0.05) and 0.08 ± 0.04 (µmol*h/L)/ µmol versus 0.08 ± 0.04 (µmol*h/L)/ µmol (2‐sample t‐test p > 0.05), respectively. No significant correlation was observed between BMI and standardized dose normalized AUC (Pearson's correlation coefficient, −0.009; p > 0.05).ConclusionWhen dosed according to BSA calculated using actual body weight there is no significant difference in paclitaxel exposure between normal and overweight women. Using alternative descriptors of weight to calculate BSA could lead to under‐dosing of this drug.Trial registrationThis study is registered in the Clinical Trials Registry of India CTRI/2015/09/006193.
Evaluation of Clinical Efficacy of Advanced Platelet‐Rich Fibrin in the Management of Gingival Recession Defects: Case Series
Authors: Chekurthi Swapna , Tadepalli Anupama , Parthasarathy Harinath , Ponnaiyan Deepa , Ramachandran Laksmi , Karthikeyan Janani 
Published: April 2021

IntroductionThe purpose of this case series is to evaluate the clinical efficacy of advanced platelet‐rich fibrin (A‐PRF) in combination with coronally advanced flap (CAF) in the management of gingival recession defects and its first of its kind.Case seriesFourteen systemically healthy patients presenting with 35 RT1 recession defects were treated with A‐PRF + CAF. Recession height (RH), recession width (RW), probing pocket depth (PPD), clinical attachment level (CAL), keratinized tissue height (KTH), and width of attached gingiva (WAG) were measured at baseline, 3, and 6 months. Gingival thickness (GTH) and phenotype were evaluated at baseline and 6 months postsurgery. Mean root coverage percentage (MRC%) was estimated at 3 and 6 months. At the end of 6 months, esthetics was measured on the scale of visual analogue scale (VAS) and recession esthetic scale (RES). Statistically significant reduction in mean RH was observed from baseline (2.49 ± 0.65 mm) to 6 months (0.66 ± 0.80 mm). At 6 months, the MRC% attained was 75.94 ± 26.72. Complete root coverage was achieved in 18 sites. At 6 months, there was a significant gain in GTH, CAL, WAG, and KTH (p ≤ 0.001). The mean RES and VAS esthetic scores were 8.54 ± 1.57 and 8.83 ± 1.17, respectively.ConclusionBased on the findings of this study, A‐PRF may be suggested as a viable treatment option for the management of recession in maxillary anteriors and premolars.
Structural Insights into the Molecular Recognition Mechanism of the Cancer and Pathogenic Epitope, LacdiNAc by Immune‐Related Lectins
Authors: Lima Carlos D. L. , Coelho Helena , Gimeno Ana , Trovão Filipa , Diniz Ana , Dias Jorge S. , Jiménez‐Barbero Jesús , Corzana Francisco , Carvalho Ana Luísa , Cabrita Eurico J. , Marcelo Filipa 
Published: April 2021

AbstractInteractions of glycan‐specific epitopes to human lectin receptors represent novel immune checkpoints for investigating cancer and infection diseases. By employing a multidisciplinary approach that combines isothermal titration calorimetry, NMR spectroscopy, molecular dynamics simulations, and X‐ray crystallography, we investigated the molecular determinants that govern the recognition of the tumour and pathogenic glycobiomarker LacdiNAc (GalNAcβ1‐4GlcNAc, LDN), including their comparison with the ubiquitous LacNAc epitope (Galβ1‐4GlcNAc, LN), by two human immune‐related lectins, galectin‐3 (hGal‐3) and the macrophage galactose C‐type lectin (hMGL). A different mechanism of binding and interactions was observed for the hGal‐3/LDN and hMGL/LDN complexes, which explains the remarkable difference in the binding specificity of LDN and LN by these two lectins. The new structural clues reported herein are fundamental for the chemical design of mimetics targeting hGal‐3/hMGL recognition process.
Metal‐Free Visible‐Light Synthesis of Arylsulfonyl Fluorides: Scope and Mechanism
Authors: Louvel Dan , Chelagha Aida , Rouillon Jean , Payard Pierre‐Adrien , Khrouz Lhoussain , Monnereau Cyrille , Tlili Anis 
Published: April 2021

AbstractThe first metal‐free procedure for the synthesis of arylsulfonyl fluorides is reported. Under organo‐photoredox conditions, aryl diazonium salts react with a readily available SO2 source (DABSO) to afford the desired product through simple nucleophilic fluorination. The reaction tolerates the presence of both electron‐rich and ‐poor aryls and demonstrated a broad functional group tolerance. To shed the light on the reaction mechanism, several experimental techniques were combined, including fluorescence, NMR, and EPR spectroscopy as well as DFT calculations.
Regenerable Sorbents for High‐Temperature Desulfurization of Syngas from Biomass Gasification
Authors: Ma Jianyu , Mahmoodinia Mehdi , Rout Kumar R. , Blekkan Edd A. 
Published: April 2021

AbstractSingle‐metal high‐temperature solid sorbents for syngas cleaning using Mn, Ca, Fe, Cu, or Mo supported on γ‐Al2O3 were synthesized, characterized, and tested in a fixed‐bed reactor. H2S and SO2 concentrations in the gas after treatment at T = 400 to 700 °C were compared with thermodynamic calculations. The Mn‐based sorbent showed the best ability to achieve a low sulfur residual in the gas, especially at temperatures above 600 °C. Sorbents with Fe, Cu, and Mo gave SO2 formation in the initial phase, but this could be avoided by a pre‐reduction treatment of the sorbent material.
Reassessing the Physicochemical Properties of Ordered Mesoporous Polymer and Copolymer Nanocasts
Authors: Bilodeau Simon , Florek Justyna , Kleitz Freddy 
Published: April 2021

AbstractNanocasting is a convenient way for preparing highly porous, nanostructured soft materials. Mesoporous polymer nanocasts have been reported for over a decade, however, several aspects remain to be explored further. To do so, we report a comprehensive investigation of the physicochemical characteristics of high surface area functional organic polymers and copolymers obtained by nanocasting. Divinylbenzene, styrene and chloromethyl styrene were selectively polymerized within the pores of mesoporous SBA‐15 or KIT‐6 silicas. Following template removal, the resulting materials were characterized. The nanocast mesoporous polymers were also modified to introduce functional groups. The success of the functionalization was assessed analytically and by model catalytic tests. The study points to the advantages of the hard templating method for structuring organic materials but also its limitations.
Characterizing participants in the North Carolina Breast and Cervical Cancer Control Program: A retrospective review of 90,000 women
Authors: Tait Sarah D. , Ren Yi , Horton Cushanta C. , Oshima Sachiko M. , Thomas Samantha M. , Wright Sherry , Caesar Awanya , Plichta Jennifer K. , Hwang E. Shelley , Greenup Rachel A. , Rosenberger Laura H. , DiLalla Gayle D. , Menendez Carolyn S. , Tolnitch Lisa , Hyslop Terry , Nelson Debi , Fayanju Oluwadamilola M. 
Published: April 2021

BackgroundThe North Carolina Breast and Cervical Cancer Control Program (NC BCCCP) provides breast cancer screening services to underserved women to mitigate disparities in access to care. The authors sought to characterize this understudied population.MethodsWomen 21 years old or older who underwent their first breast cancer screen through NC BCCCP from 2008 to 2018 were included. Demographic factors associated with the timeline of care and odds of a breast cancer diagnosis were identified with negative binomial and logistic regression, respectively.ResultsOf the 88,893 women identified, 45.5% were non‐Hispanic (NH) White, 30.9% were NH Black, 19.6% were Hispanic, 1.7% were American Indian, and 1.1% were Asian. Breast cancer was diagnosed in 2.5% of the women (n = 2255). Hispanic women were the least likely to be diagnosed with breast cancer (odds ratio vs NH White women, 0.40; 95% confidence interval [CI], 0.34‐0.47). Among patients with breast pathology, the median time to diagnosis was 19 days (interquartile range [IQR], 10‐33 days), and the time to treatment was 33 days (IQR, 19‐54 days). After adjustments, a longer time to diagnosis was significantly associated with age (incidence rate ratio [IRR], 1.01; 95% CI, 1.01‐1.02) and being NH Black (vs NH White; IRR, 1.17; 95% CI, 1.06‐1.29). A longer time to treatment was significantly associated with age (IRR, 1.01; 95% CI, 1.01‐1.01), being NH Black (vs NH White; IRR, 1.20; 95% CI, 1.10‐1.31), and being Hispanic (vs NH White; IRR, 1.22; 95% CI, 1.05‐1.41).ConclusionsNC BCCCP participants with breast cancer received treatment within approximately 1 month of presentation, and this finding aligns with quality care benchmarks. Nevertheless, racial/ethnic disparities in timeliness of care persist, and this suggests opportunities for improvement.Lay Summary

This review of approximately 90,000 participants in a breast cancer screening program for uninsured and underinsured women highlights the importance of safety net programs in providing timely care to underserved patients.

The authors found that the North Carolina Breast and Cervical Cancer Control Program met timeliness benchmarks from the Centers for Disease Control and Prevention across all racial/ethnic groups. However, non‐Hispanic Black women experienced relative delays in the time to diagnosis, and both non‐Hispanic Black women and Hispanic women experienced relative delays in the time to treatment.

These findings demonstrate how racial/ethnic disparities in the timeliness of care can persist even within a program intended to reduce barriers to access.
Disparities in accessibility to evidence‐based breast cancer care facilities by rural and urban areas in Bavaria, Germany
Authors: Stangl Stephanie , Rauch Sebastian , Rauh Jürgen , Meyer Martin , Müller‐Nordhorn Jacqueline , Wildner Manfred , Wöckel Achim , Heuschmann Peter U. 
Published: April 2021

BackgroundBreast cancer (BC), which is most common in elderly women, requires a multidisciplinary and continuous approach to care. With demographic changes, the number of patients with chronic diseases such as BC will increase. This trend will especially hit rural areas, where the majority of the elderly live, in terms of comprehensive health care.MethodsAccessibility to several cancer facilities in Bavaria, Germany, was analyzed with a geographic information system. Facilities were identified from the national BC guideline and from 31 participants in a proof‐of‐concept study from the Breast Cancer Care for Patients With Metastatic Disease registry. The timeframe for accessibility was defined as 30 or 60 minutes for all population points. The collection of address information was performed with different sources (eg, a physician registry). Routine data from the German Census 2011 and the population‐based Cancer Registry of Bavaria were linked at the district level.ResultsFemales from urban areas (n = 2,938,991 [ie, total of females living in urban areas]) had a higher chance for predefined accessibility to the majority of analyzed facilities in comparison with females from rural areas (n = 3,385,813 [ie, total number of females living in rural areas]) with an odds ratio (OR) of 9.0 for cancer information counselling, an OR of 17.2 for a university hospital, and an OR of 7.2 for a psycho‐oncologist. For (inpatient) rehabilitation centers (OR, 0.2) and genetic counselling (OR, 0.3), women from urban areas had lower odds of accessibility within 30 or 60 minutes.ConclusionsDisparities in accessibility between rural and urban areas exist in Bavaria. The identification of underserved areas can help to inform policymakers about disparities in comprehensive health care. Future strategies are needed to deliver high‐quality health care to all inhabitants, regardless of residence.
3D Hydrangea‐like InVO4/Ti3C2Tx Hierarchical Heterosystem Collaborating with 2D/2D Interface Interaction for Enhanced Photocatalytic CO2 Reduction
Authors: Li Liang , Yang Yong , Yang Liuqing , Wang Xiaoyong , Zhou Yong , Zou Zhigang 
Published: April 2021

Abstract3D hydrangea‐like InVO4/Ti3C2Tx heterosystem is fabricated by in‐situ growth of InVO4 on Ti3C2Tx and on spot self‐assembly. The formation of a hierarchical architecture collaborating with well‐defined 2D/2D interfacial interaction is constructed by optimizing the ratio of Ti3C2Tx incorporated in the formation of InVO4. The as‐obtained InVO4/Ti3C2Tx presents improved photon trapping capacity and exposure of reactive sites owing to the enhanced BET specific surface areas, and the capture capacity towards CO2 is strengthened coordinated with the basic feature of Ti3C2Tx. Based on DFT calculations, the electron transfer from InVO4 to Ti3C2Tx is demonstrated, and the unique 2D/2D interface interaction in InVO4/Ti3C2Tx heterosystem efficiently improves the separation of photogenerated charge carriers. As a result, the 3D hierarchical InVO4/Ti3C2Tx heterosystem presents 13.83 μmol g−1 h−1 of CO production (3.1‐folds of pristine InVO4) with 92% selectivity and superior stability. The 3D hierarchical design collaborating with 2D/2D interfacial interaction provides a new avenue to develop ideal catalysts for artificial photosynthesis.
Bridging the Gap: From Homogeneous to Heterogeneous Parahydrogen‐induced Hyperpolarization and Beyond
Authors: Chekmenev Eduard Y. , Goodson Boyd M. , Bukhtiyarov Valerii I. , Koptyug Igor V. 
Published: April 2021

AbstractDemonstration of parahydrogen‐induced polarization effects in hydrogenations catalyzed by heterogeneous catalysts instead of metal complexes in a homogeneous solution has opened an entirely new dimension for parahydrogen‐based research, demonstrating its applicability not only for the production of catalyst‐free hyperpolarized liquids and gases and long‐lived non‐equilibrium spin states for potential biomedical applications, but also for addressing challenges of modern fundamental and industrial catalysis including advanced mechanistic studies of catalytic reactions and operando NMR and MRI of reactors. This essay summarizes the progress achieved in this field by highlighting the research contributed to it by our colleague and friend Kirill V. Kovtunov whose scientific career ended unexpectedly and tragically at the age of 37. His role in this research was certainly crucial, further enhanced by a vast network of his contacts and collaborations at the national and international level.
Supramolecular Sensing of Chemical Warfare Agents
Authors: Butera Ester , Zammataro Agatino , Pappalardo Andrea , Trusso Sfrazzetto Giuseppe 
Published: April 2021

AbstractChemical warfare agents are a class of organic molecules used as chemical weapons due to their high toxicity and lethal effects. For this reason, the fast detection of these compounds in the environment is crucial. Traditional detection methods are based on instrumental techniques, such as mass spectrometry or HPLC, however the use of molecular sensors able to change a detectable property (e. g., luminescence, color, electrical resistance) can be cheaper and faster. Today, molecular sensing of chemical warfare agents is mainly based on the “covalent approach”, in which the sensor reacts with the analyte, or on the “supramolecular approach”, which involves the formation of non‐covalent interactions between the sensor and the analyte. This Review is focused on the recent developments of supramolecular sensors of organophosphorus chemical warfare agents (from 2013). In particular, supramolecular sensors are classified by function of the sensing mechanism: i) Lewis Acids, ii) hydrogen bonds, iii) macrocyclic hosts, iv) multi‐topic sensors, v) nanosensors. It is shown how the supramolecular non‐covalent approach leads to a reversible sensing and higher selectivity towards the selected analyte respect to other interfering molecules.
Towards Foldameric Miniproteins: A Helix‐Turn‐Helix Motif
Authors: Ożga Katarzyna , Drewniak‐Świtalska Magda , Rudzińska‐Szostak Ewa , Berlicki Łukasz 
Published: April 2021

AbstractNumerous beta‐amino acid containing peptides forming secondary structures have been already described, however the design of higher‐order structures remains poorly explored. The methodology allowing construction of sequence patterns containing few rigid secondary element was proposed and experimentally validated. On the basis of 9/10/9/12‐helix containing cis‐2‐aminocyclopentanecarboxylic acid (cis‐ACPC) residues arranged in an ααββ sequence pattern, a conformationally stable helix‐turn‐helix structure was designed. The connection between two helices was also constructed using cis‐ACPC residues. Five examples of designed peptides were obtained and analyzed using circular dichroism and nuclear magnetic resonance spectroscopy, which confirmed the assumed way of folding. The NMR structure was calculated for the peptide with the highest number of non‐sequential contacts.
The effect of hypnosis on pain relief due to injection of dental infiltration anesthesia
Authors: Arabzade Moghadam Soma , Yousefi Fayegh , Saad Sahand 
Published: April 2021

AbstractBackground and objectiveDental patients often experience the fear of pain induced by injectable anesthesia. This study aimed to investigate the impact of hypnosis on relieving the pain of injected dental infiltration anesthesia.Materials and methodsThis single‐blind clinical trial was conducted on 32 healthy volunteers to assess the pain perception in mucosal injection. The visual analog scale was applied for the measurement of one‐sided pain intensity in the maxilla without hypnosis. When hypnosis was implemented, the same procedure was performed on the other side of the maxilla reversely within one session.ResultsHypnosis implementation significantly decreased the intensity of the perceived pain before anesthesia injection (p = 0.05).ConclusionHypnosis before the injection of dental infiltration anesthesia could decrease the pain intensity caused by the injection. Therefore, hypnosis therapy is recommended as an effective approach to pain control for anesthesia injection.
Co‐Catalyzed Synthesis of Primary Amines via Reductive Amination employing Hydrogen under very mild Conditions
Authors: Elfinger Matthias , Schönauer Timon , Thomä Sabrina L. J. , Stäglich Robert , Drechsler Markus , Zobel Mirijam , Senker Jürgen , Kempe Rhett 
Published: April 2021

AbstractNanostructured and reusable 3d‐metal catalysts that operate with high activity and selectivity in important chemical reactions are highly desirable. Here, a cobalt catalyst was developed for the synthesis of primary amines via reductive amination employing hydrogen as the reducing agent and easy‐to‐handle ammonia, dissolved in water, as the nitrogen source. The catalyst operates under very mild conditions (1.5 mol% catalyst loading, 50 °C and 10 bar H2pressure) and outperforms commercially available noble metal catalysts (Pd, Pt, Ru, Rh, Ir). A broad scope and a very good functional group tolerance were observed. The key for the high activity seemed to be the used support: an N‐doped amorphous carbon material with small and turbostratically disordered graphitic domains, which is microporous with a bimodal size distribution and with basic NH functionalities in the pores.