bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decades of research supporting malaria control and elimination in China: a bibliometric analysis of academic articles published in Chinese from 1980 to 2019
Authors: Du Yan-Qiu , Zhu Guo-Ding , Cao Jun , Huang Jia-Yan 
Published: January 2021

Abstract
Background: China has accumulated a lot of experience on malaria control and elimination in the past few decades. Many research papers have been published in Chinese journals. This study intends to obtain the development path and experience of malaria control and elimination in China by quantitatively analyzing these local journals based on the bibliometric analysis.Methods: A long-term, multi-stage bibliometric analysis was implemented. Research articles published in Chinese journals from 1980 to 2019 were retrieved from Wanfang database and China National Knowledge Infrastructure (CNKI). Year of publication, journal name and keywords were extracted by the Bibliographic Items Co-occurrence Matrix Builder (BICOMB). We defined the K/A ratio (the percentage of a keyword frequency in the number of articles within a certain period) as an indicator for measuring the popularity of a keyword in different decades. And we used the software VOSviewer to make keyword co-occurrence network maps.Results: A total of 16,290 articles were included. The overall trend of articles continues to rise. However, the articles published in the past three years had continued to decline. There are two kinds of trends of the keyword frequency between different decades. The K/A ratio of keywords such as ‘Plasmodium falciparum’ continued to decline (17.05% in 1980s, 13.04% in 1990s, 9.86% in 2000s, 5.28% in 2010s), but ‘imported case’ and ‘surveillance’ continued to rise. Drug resistance always was a concern. The keyword co-occurrence network maps showed that the themes in malaria research were becoming more diverse, and the degree of multidisciplinary cooperation was gradually deepening.Conclusion: This bibliometric analysis reveals the trends in malaria research in China over the past 40 years. The results suggest the high attention on the investigation, multidisciplinary participation and drug resistance for researchers and policymakers in malaria-epidemic areas. And the results also provided domestic experts with qualitative evidence for the summary of China's experience on malaria control and elimination.
A Novel Epitope-blocking ELISA for Specific and Sensitive Detection of Antibodies against H5-Subtype Influenza Virus Hemagglutinin
Authors: Sączyńska Violetta , Florys-Jankowska Katarzyna , Porębska Anna , Cecuda-Adamczewska Violetta 
Published: January 2021

Abstract
Background: H5-subtype highly pathogenic (HP) avian influenza viruses (AIVs) cause high mortality in domestic birds and sporadic infections in humans with a frequently fatal outcome, while H5N1 viruses have pandemic potential. Due to veterinary and public health significance, these HPAIVs, as well as low pathogenicity (LP) H5-subtype AIVs having a propensity to mutate into HP viruses, are under epidemiologic surveillance and must be reported to the World Organization for Animal Health (OIE). Our previous work provided a unique panel of 6 different monoclonal antibodies (mAbs) against H5 hemagglutinin (HA), which meets the demand for high-specificity tools for monitoring AIV infection and vaccination in poultry. In this study, we selected one of these mAbs to develop an epitope-blocking (EB) ELISA for detecting H5 subtype-specific antibodies in chicken sera (H5 EB-ELISA).Methods: In the H5 EB-ELISA, H5 HA protein produced in a baculovirus-expression vector system was employed as a coating antigen, and the G-7-27-18 mAb was employed as a blocking antibody. The performance characteristics of the assay were evaluated by testing 358 sera from nonimmunized chickens and chickens immunized with AIVs of the H1–H16 subtypes or recombinant H5 HA antigen to obtain the reference and experimental antisera, respectively. The samples were classified as anti-H5 HA positive or negative based on the results of the hemagglutination inhibition (HI) assay, the gold standard in subtype-specific serodiagnosis.Results: The H5 EB-ELISA correctly discriminated between the anti-H5 HA negative sera, including those against the non-H5 subtype AIVs, and sera positive for antibodies against the various-origin H5 HAs. Preliminary validation showed 100% analytical and 97.6% diagnostic specificities of the assay and 98.0% and 99.1% diagnostic sensitivities when applied to detect the anti-H5 HA antibodies in the reference and experimental antisera, respectively.Conclusions: The H5 EB-ELISA performed well in terms of diagnostic estimates. Thus, further optimization and validation work using a larger set of chicken sera and receiver operating characteristic (ROC) analysis are warranted. Moreover, the present assay provides a valuable basis for developing multispecies screening tests for birds or diagnostic tests for humans.
Nebulization therapy with umbilical cord mesenchymal stem cell-derived exosomes for COVID-19 pneumonia
Authors: Chu Meiping , Wang Hao , Bian Linjie , Huang Jiehui , Wu Danping , Fei Fangli , Zhang Ruiting , Chen Yigang , Xia Jiazeng 
Published: January 2021

Abstract
Background: Scientists have been facing numerous challenges in the development of an effective therapeutic strategy for the treatment of COVID-19 pneumonia. Several studies have suggested that improving patient immunity and reducing lung injury induced by SARS-CoV-2 may be effective for treating patients with COVID-19.Methods: A pilot trial of nebulization therapy with exosomes of mesenchymal stem cells (MSCs) was performed on seven patients with COVID-19 pneumonia. Exosomes secreted from MSCs were collected and purified using multiple ultrafiltration steps. All patients were treated with nebulization of MSC-derived exosomes, and primary safety and efficacy outcomes were evaluated.Results: Our clinical study demonstrated that nebulization of MSC-derived exosomes is a novel method that might be utilized in the treatment of COVID-19 pneumonia. Nebulization of MSC-derived exosomes did not induce acute allergic or secondary allergic reactions but did promote the absorption of pulmonary lesions and reduce the time of hospitalization for mild cases of COVID-19 pneumonia.Conclusions: Nebulization of MSC-derived exosomes is a safe, effective, and simple method, and their application at the beginning of treatment may be more beneficial.Trial registration: Chinese Clinical Trial Registry, ChiCTR2000030261. Registered on 26 February 2020.
Novel Niacin Receptor Agonists: A Promising Strategy for the Treatment of Dyslipidemia
Authors: Kothawade Prajakta B. , Thomas Asha B. , Chitlange Sohan S. 
Published: January 2021

Background:
Hyperlipidemia is characterized by high level of cholesterol and triglycerides in blood. Various
classes of drugs like statins, fibrates, niacin etc. are used for treatment of hyperlipidaemia.

Objective:
Niacin, which is one of the beneficial anti-hyperlipidemic agents, helps to lower LDL cholesterol by 20 to 40%
and causes increase of HDL cholesterol by 20 to 35%. However cutaneous flushing, loss of glucose tolerance, liver toxicity
are the reported side effects of niacin therapy responsible for decreased patient compliance. Very recently, the G protein
coupled receptor (GPCR); GPR109A located on the adipocytes has been identified as the receptor for activation of niacin.

Method:
In-vitro studies have demonstrated that GPR109A receptor having high affinity for niacin. The present review
attempts to provide a systematic presentation of the various chemical classes of compounds that have been reported as novel
niacin receptor agonists including pyrazole-3-carboxylic acids, urea derivatives, anthranilic acids, biaryl anthranilides,
tetrahydro anthranilic acid, xanthines, barbituric acid, bicyclic pyrazole carboxylic acids, pyrido pyrimidinones, pyrazolyl
propionyl cyclohexenamides, pyrazole acids etc.

Results:
As the design of GPR109A receptor agonists offers a promising solution for treatment of dyslipidemia, this review
will be beneficial for medicinal and drug discovery chemists to expediate the process of discovery of new class of antihyperlipidemic agent with favorable lipid lowering profile with increase in HDL levels.

Conclusion:
This review explains about novel GPR109A receptor agonist for the treatment of dyslipidemia.
Visible Light Mediated, Catalyst Free, One-Pot Convenient Synthesis of
Dihydropyridines
Authors: Di Jia-Qi , Chen Meng-Nan , Zhao Ai-Dong , Zhang Zhan-Hui 
Published: January 2021

:
A simple, efficient and green protocol has been developed for the synthesis of polysubstituted dihydropyridines
via one-pot, four-component reaction of aldehydes, arylamines, dialkyl acetylenedicarboxylate, and malononitrile. The reaction was proceeded at room temperature in the absence of catalyst in aqueous ethyl lactate under visible light irradiation.
The main advantages of the present approach are mild reaction condition, high yield, no column chromatography, clean
reaction profile, environmentally friendly and sustainable from the economic point of view
Pemetrexed – First-Line Therapy for Non-Squamous Non-Small Cell Lung Cancer: A Review of Patent Literature
Authors: Vora Pratik Ashwinbhai , Patel Rakesh , Dharamsi Abhay 
Published: January 2021

Background:
Pemetrexed is a folate analogue metabolic inhibitor for mammalian cells.
Pemetrexed is toxic to several cancer cells by interfering with their new biosynthesis of nucleotides,
thus causing cell apoptosis. Presently, Pemetrexed is given to patients with Non-Small
Cell Lung Cancer (NSCLC).

Objective:
This review focuses on the recent patents of Pemetrexed. This assessment includes patents
grouped in segments like crystalline form patent, composition related patents, product patents,
as well as a method of treatment. The aim of this review is to simplify inventors with existing
patents in a single place.

Methods:
Data were searched from several available databases, including paid databases which include
Orbit® and SciFinder®. Free databases include Worldwide Espacenet® (EPO), Patentscope®
(WIPO), InPASS (Indian patent database) and Google Patents.

Results:
Some new polymorph and composition-related inventions of Pemetrexed have been recently
patented as its orange-book listed patents will soon expire in May 2022. Further, because of the
problem of oxidation through the development and continuing storage of Pemetrexed composition,
several excipients are experimented with within these patents to stabilize the same. Nevertheless,
there is a need for further development of an improved composition of Pemetrexed with improved
characteristics.

Conclusion:
Wide research has been conducted on different processes for preparing Pemetrexed
and formulation thereof. Such type of active research may clear the track for the generic companies
in the United States, producing the formulation at low prices and providing universal health care at
economical prices.
Concepts on Smart Nano-Based Drug Delivery System
Authors: Rai Shweta , Singh Neeraj , Bhattacharya Sankha 
Published: January 2021

Abstract:
Nanomedicine is a branch of healthcare, which has many clinical applications. Nanoscale science has to
presume an attractive slot for research in drug delivery as nanocarriers either through active or passive targeting
approaches to the cell-specific drug delivery. Liposomes, solid-lipid nanoparticles, dendrimers, polymeric nanoparticles,
mesoporous silica nanoparticles, inorganic nanoparticles, nanotubes, quantum dots, and nanofibers are nanocarriers that
are proved too smart nano-based drug delivery system. The nanoparticulate system shows high stability, high specificity,
high efficacy, liability to form in different dosage, used through different routes, as well as the ability to deliver
hydrophobically as well as hydrophilic drugs. These nanoparticulate systems are showing wider applications to cure the
disease through nanomedicines and biomedical applications viz. chemical and biological sensors, information storage
systems, magneto-optic, optical devices, and fiber-optic systems. In this review article, the author describes the various
smart nano-based drug delivery system along with their endocytic pathways used for the uptake of nanoparticles.
Recent Advances on the Application of Graphene Quantum Dots in Energy Storage
Authors: Shi Feng , Liu Quanrun 
Published: January 2021

Background:
As an emerging carbon nanomaterial, Graphene Quantum Dots (GQDs)
have shown great potential application in new energy storage devices due to their unique small size
effect and abundant edge active sites. This work introduces the main synthesis strategies of GQDs,
which include top-down and bottom-up methods; the application examples of GQDs and GQDsbased
composites in energy storage are reviewed, moreover, the unique advantages of GQDs in supercapacitors,
Lithium-Ion Batteries (LIBs) and Lithium-sulfur batteries (Li–S batteries) are highlighted.
The problems and development prospects in this growing area are also discussed.

Methods:
We conducted a detailed search of “the application of GQDs in energy storage devices” in
the published papers and the public patents based on the Web of Science database in the period from
2014 to 2020. The corresponding literature was carefully evaluated and analyzed.

Results:
Sixty papers and twenty-eight recent patents were included in this mini-review. The significant
advances in recent years are summarized with comparative and balanced discussion. Thanks to
the unique properties of large specific surface area, high conductivity and abundant active sites,
GQDs have unparalleled potential application for new energy storage, especially improving the specific
capacity and cycle stability of supercapacitors, LIBs and Li-S batteries.

Conclusion:
The findings of this mini-review confirm the importance of GQDs, show the enhanced
electrochemical performance in supercapacitors, LIBs and Li-S batteries, and also provide a helpful
guide to design and fabricate high-efficiency electrode materials.
Novel Strategy in Breast Cancer Therapy: Revealing The Bright Side of Ginsenosides
Authors: Hashemi Farid , Zarrabi Ali , Zabolian Amirhossein , Saleki Hossein , Farahani Mahdi V. , Sharifzadeh Seyed O. , Ghahremaniyeh Zahra , Bejandi Atefe K. , Hushmandi Kiavash , Ashrafizadeh Milad , Khan Haroon 
Published: January 2021

:
Breast cancer is one of the leading causes of death worldwide. Breast cancer cells demonstrate
uncontrolled proliferation and high metastatic capacity. They can obtain resistance to
chemotherapy and radiotherapy. This has resulted in troublesome treatment of breast cancer. Nature
as a rich source of plant derived-natural products with anti-tumor activity can be of interest in
breast cancer therapy. Ginsenosides are triterpenoid saponins and considered as secondary metabolites
exclusively found in Panax species. From immemorial times, ginsenosides have been applied
in the treatment of various disorders such as diabetes, inflammatory diseases, neurological disorders,
and particularly, cancer. In the present review, we highlight the anti-tumor activity of ginsenosides
against breast cancer cells. Ginsenosides are able to induce apoptosis and cell cycle arrest.
They interfere with breast cancer metastasis via inhibiting epithelial-to-mesenchymal transition,
matrix metalloproteinase proteins and angiogenesis. Ginsenosides can promote the efficacy of chemotherapy
via suppressing migration and proliferation. Molecular pathways such as phosphatidylinositol
3-kinase (PI3K)/protein kinase B (Akt), insulin-like growth factor-1, Wnt, microRNAs and
long non-coding RNAs are affected by ginsenosides in suppressing breast cancer malignancy.
Consequently, ginsenosides are versatile compounds in breast cancer therapy by suppressing the
growth and invasion, as well as promoting their sensitivity to chemotherapy.
The Radiosensitizing Effect of Olanzapine as an Antipsychotic Medication
on Glioblastoma Cell
Authors: Hosseinimehr Seyed Jalal , Allahgholipour Seyedeh Zahra , Farzipour Soghra , Ghasemi Arash , Asgarian-Omran Hossein 
Published: January 2021

Background:
Radiotherapy is used as one of the most effective regimens for cancer
treatment, while radioresistance is a major drawback in cancer treatment.

Objectives:
This study aimed to evaluate the sensitizing effect of olanzapine (OLA) with X-ray on
glioblastoma (U-87 MG) cells death.

Methods:
The synergistic killing effect of OLA with ionizing radiation (IR) on glioma was evaluated
by colony formation assay. The generations of reactive oxygen species (ROS) and protein carbonyl
(PC) as oxidized proteins were determined in OLA-treated and irradiated cells.

Results:
Results of this study showed that OLA reduced the number of colonies in irradiated glioma
cells.OLA elevated ROS and PC levels in irradiated cells. The synergistic killing effect of OLA
with IR in U-87 MG cells was observed at concentrations of 1 μM and 20 μM of OLA. The maximum
radiosensitizing effect of OLA was observed at a concentration of 20 μM.

Conclusion:
The present study demonstrates that OLA has a radiosensitizing effect on cell death induced
by IR in glioma cells.
Recent Developments in Medicated Lozenges: A Promising Dosage Form for the Effective Delivery of Therapeutic Agents
Authors: Sharma Deepak , Kumar Dinesh , Singh Gurmeet 
Published: January 2021

:The delivery of therapeutic agents through the oral route remains the most favorable one as compared to other routes of drug administration. However, numerous disadvantages are encountered in conventional formulations such as low bioavailability, first-pass metabolism, gastric irritation, delayed onset of action, bitter taste, low retention time, frequent dosing, and non-localized drug targeting. All these problems encountered guide the various pharmaceutical industries to manufacture and develop a novel solid oral dosage form called lozenges. Lozenges are solid oral dosage forms of medicament, meant to be dissolved within the mouth or pharynx. They may consist of one or more than one medicinal agent in a sweetened and flavored base material.:The present review is focused on various types, compositions, and methodologies used to prepare the medicated lozenges and on different evaluation parameters that establish their safety and efficacy. It also put a light on different commercially available and reported medicated lozenges formulation.:The various review and research articles reported by different researchers were studied extensively by using the databases of Google Scholar, Pubmed, Scopus, Web of Science and various commercial websites that were also investigated for information regarding new products.:Lozenges provide various advantages in terms of patient compliance, rapid onset of action, prolonged retention time, enhancement of bioavailability, ease of manufacturing, localized drug targeting, sustained or controlled effect, and reduced dosing frequency. They also have the ability to incorporate the drugs belonging to different therapeutic classes for treating various disorders related to oral cavities like gingivitis, dental plaque, mouth ulcers, throat pain, oral thrush, throat infection, periodontitis, and pharyngitis. However, its applicability is not only limited to localized action, but it has also been employed to deliver the drug systemically for the conditions such as cough, decongestion, runny nose, nausea, vomiting, allergy, low immunity, fever, body ache, the killing of worms and smoking cessation.:It was concluded that they have played an important role in the field of drug delivery and will continue to perform in the same way in the future as well.
Construction of Efficient Wireless Sensor Networks for Energy Minimization Using a Modified ACO Algorithm
Authors: Dey Monojit , Das Arnab , Banerjee Avishek , Kamila Ujjwal Kumar , Chattopadhyay Samiran 
Published: January 2021

In this paper, we have proposed different deployment strategies and have applied area-wise
clustering along with modified Ant Colony Optimization to minimize energy consumption.

Background:
Previously, some deployment strategies were used to enhance the lifetime of WSN. In our
research, we have applied some novel deployment strategies like random, spiral, and S-pattern along
with a novel area-wise clustering process to get better results than the existing literature, as shown in
Table 4.

Objective:
The main objective of the research article is to enhance the lifetime of Wireless Sensor
Network with the help of different deployment strategies like random, spiral, and S-pattern). A novel
clustering process (i.e., area-wise clustering), and a Meta-heuristic algorithm (modified ACO) are applied.

Methods:
We have applied different methods for deployment strategies (random, spiral, and S-pattern).
A novel clustering process (i.e., area-wise clustering), and a Meta-heuristic algorithm (modified ACO)
are applied to get the desired results.

Results:
Random Deployment: 11.15 days to 15.09 days. Spiral Deployment: 11.25 days to 15.23 days.
S-Pattern Deployment: 11.33 days to 15.33 days.

Conclusion:
In this paper, efficient Wireless Sensor Networks have been configured considering energy
minimization as the prime concern. To minimize the energy consumption, a modified ACO algorithm
has been proposed. In our work, the minimization of energy consumption leads to an increment of the
lifetime of WSN to a significant margin theoretically. The obtained result has been compared with the
existing literature and it has been found that the proposed algorithm produced a better result than the
existing literature.
A Wrapper Based Feature Selection Using Grey Wolf Optimization for Botnet Attack Detection
Authors: Penmatsa Ravi Kiran Verma , Mallidi S Kumar Reddy , Muni Rohit Rishi 
Published: January 2021

Aim:
To design and evaluate the performance of a Grey Wolf Optimization (GWO) based
wrapper feature selection applied to the Botnet malware detection system.

Background:
A botnet is malicious software controlled by a master and used to compromise a distributed
set of systems, in turn targeting a victim. Powerful attacks like Distributed Denial of Service (DDoS)
can be triggered using a botnet. With the rapid growth of the Internet of Things (IoT) and its omnipresence,
the vulnerable IoT devices are also under threat of being a victim or a zombie.

Objective:
To optimize the listed botnet data traffic features, Grey Wolf Optimization (GWO), in a
wrapper model, is used to search the useful features without affecting the classification accuracy.

Method:
The Botnet dataset consists of a total of 192 Command and Control (C&C) botnet channels
HTTP traffic features, and network traffic session-based features. GWO optimization algorithm is used
as a wrapper for feature selection, and evaluated on three different classifiers, viz., SVM, KNN, and DT.

Results:
Decision Tree (DT) and GWO wrapper produced the best results when compared with other
classifiers. The output of the research reduces the botnet traffic features to 19 from 192, with an accuracy
of 99.73% post the reduction.

Conclusion:
The proposed DT-GWO wrapper turns out to be an excellent choice for feature reduction
for botnet attack detection. The strength of the DT-GWO wrapper is that it is able to retain the near fullfeature
accuracy even after a massive reduction of 90.10% of the features.