bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protective HLA Alleles Recruit Biased and Largely Similar Antigen-Specific T Cell Repertoires across Different Outcomes in HIV Infection
Authors: Koning Dan , Quakkelaar Esther D , Schellens Ingrid M M , Spierings Eric , van Baarle Debbie 
Published: December 2021

Abstract
CD8+ T cells play an important role in the control of untreated HIV infection. Several studies have suggested a decisive role of TCRs involved in anti-HIV immunity. HLA-B*27 and B*57 are often associated with a delayed HIV disease progression, but the exact correlates that provide superior immunity against HIV are not known. To investigate if the T cell repertoire underlies the protective effect in disease outcome in HLA-B*27 and B*57+ individuals, we analyzed Ag-specific TCR profiles from progressors (n = 13) and slow progressors (n = 11) expressing either B*27 or B*57. Our data showed no differences in TCR diversity between progressors and slow progressors. Both alleles recruit biased T cell repertoires (i.e., TCR populations skewed toward specific TRBV families or CDR3 regions). This bias was unrelated to disease progression and was remarkably profound for HLA-B*57, in which TRBV family usage and CDR3 sequences were shared to some extent even between epitopes. Conclusively, these data suggest that the T cell repertoires recruited by protective HLA alleles are highly similar between progressors and slow progressors in terms of TCR diversity, TCR usage, and cross-reactivity.
Intrinsic Antiviral Activity of Optineurin Prevents Hyperproliferation of a Primary Herpes Simplex Virus Type 2 Infection
Authors: Patil Chandrashekhar D , Suryawanshi Rahul , Ames Joshua , Koganti Raghuram , Agelidis Alex , Kapoor Divya , Yadavalli Tejabhiram , Koujah Lulia , Tseng Henry C , Shukla Deepak 
Published: December 2021

Abstract
Very little knowledge exists on virus-specific host cell intrinsic mechanisms that prevent hyperproliferation of primary HSV type 2 (HSV-2) genital infections. In this study, we provide evidence that the Nemo-related protein, optineurin (OPTN), plays a key role in restricting HSV-2 infection both in vitro and in vivo. Contrary to previous reports regarding the proviral role of OPTN during Sendai virus infection, we demonstrate that lack of OPTN in cells causes enhanced virus production. OPTN deficiency negatively affects the host autophagy response and results in a marked reduction of CCL5 induction. OPTN knockout (OPTN−/−) mice display exacerbated genital disease and dysregulated T cell frequencies in infected tissues and lymph nodes. A human transcriptomic profile dataset provides further credence that a strong positive correlation exists between CCL5 upregulation and OPTN expression during HSV-2 genital infection. Our findings underscore a previously unknown OPTN/CCL5 nexus that restricts hyperproliferative spread of primary HSV-2 infection, which may constitute an intrinsic host defense mechanism against herpesviruses in general.
Faktor yang Berhubungan dengan Perilaku Perawat dalam Pemakaian APD di Ruang Rawat Inap Salah Satu Rumah Sakit Swasta di Yogyakarta
Authors: Mawarni V.Endah , Widyastuti Ch. Setya , Marti Eva 
Published: December 2021

ABSTRACT
Backround: Nurses' behavior in using PPE is considered very important in improvingthe quality of health services as well as the occupational safety and health of nurses inhospitals

Objective: To determine the factors related to the behavior of nurses in nusing personal protective equipment in the inpatient unit Private Hospital at Yogyakarta.
Methods: This study used a quantitative descriptive research design with a cross sectional approach, with a total sample of 30 respondents. The sample obtained by the total population technique. The data collection methods used were questionnaires and observations.

Results: The study showed that most of the nurses had good enough behavior, 63,3%, almost half of them had good behavior, 33,3% and a small proportion of bad behaviorwas 3,3%. As much as 70% have good knowledge, a small proportion of knowledge isgood enough, 13,3% and a small proportion of knowledge is not good 16,7%. Most ofthe attitudes are quite positive 53,3%, almost half are positive attitudes are 40% and a small have negative attitudes 6,7%.

Conclusion: It is hoped that the hospital will provide socialization and practice of usingPPI by PPI to inpatient room nurses once every 3 months and raise awareness and remind fellow nurses to wear PPE according to the SPO.
Maximum Allowable Pressure Calculation of Water Tube Boiler during Operation
Authors: Elmaryami Abdlmanam , Ahmida Mahmoud Abdelrazek , Muhammad Walid Saleh 
Published: December 2021

In the steam boiler industrial sector, pressure and temperature of the water tube are the two main factors that affect the safety and efficiency of a steam boiler. Explosions may be occurring because of a sudden drop in pressure without a corresponding drop in temperature. Therefore, understanding the temperature distribution of the water tube boiler is essential to control the failure and explosion of the boiler. Once the temperature distribution is known than the limiting factors that affect the water tube life such as the maximum allowable pressure can be determined. ANSYS software will be used to determine the temperature distribution in the water tube of a utility boiler during operation at elevated inlet water and furnace temperature. The theory of axisymmetric has been utilized since the water- tube is cylindrical in shape. In axisymmetric theory, a three-dimensional cylindrical problem like a water tube can be reduced to two-dimensional by ignoring the circumferential Ө, while the r-axis and z-axis became x-axis and y-axis or Cartesian coordinate. Then two-dimensional rectangular elements meshing for the profile cross-section along the water tube in r and z axes were implemented in a computerized simulation using ANSYS 10 to find out the steady-state temperature distribution of the water tube.
Evaluasi Penyiapan Proyek Kerjasama Pemerintah Dengan Badan Usaha (KPBU) Kereta Api Makassar-Parepare
Authors: Abdi Patu Andi Syafirah Putri , Akhmadi Muhammad Heru 
Published: December 2021

Public-Private Partnership (PPP) is an infrastructure project financing system developed to solve the limited development budget. The Makassar-Parepare railway is the first PPP project handled by the Ministry of Transportation as the PJPK. This paper aims to evaluate the preparation stage of the Makassar-Parepare project. The research method used is descriptive qualitative. Primary data was collected through interviews. The data obtained were analyzed using the ATLAS.ti application. The results of the study indicate that the PPP preparation of the Makassar-Parepare project has generally been well carried out based on regulations. However, there are some obstacles in the preparation process, such as schedule delays due to land acquisition and the lack of understanding of the person in charge of the cooperation program because of unpreparedness of human resources. Thus, good organizational coordination is needed in the preparation process of the PPP project.
Abstrak
Kerjasama Pemerintah dengan Badan Usaha (KPBU) merupakan suatu sistem pembiayaan proyek infrastruktur yang dikembangkan dalam rangka mengatasi keterbatasan anggaran pembangunan. Salah satu proyek strategis nasional yang menggunakan skema KPBU saat ini yaitu proyek KPBU Kereta Api (KA) Makassar-Parepare. Tulisan ini bertujuan untuk mengevaluasi tahap penyiapan proyek KPBU KA Makassar-Parepare. Metode penelitian yang digunakan adalah kualitatif deskriptif. Data primer dikumpulkan melalui proses wawancara, sedangkan data sekunder dikumpulkan melalui studi pustaka dan peraturan yang relevan dengan objek penelitian. Data yang diperoleh dianalisis dengan menggunakan aplikasi ATLAS.ti. Hasil penelitian menunjukkan bahwa penyiapan proyek KPBU KA Makassar-Parepare pada umumnya telah dilaksanakan sesuai dengan peraturan yang ada. Meski demikian, terdapat kendala dalam proses penyiapan seperti pada proses penetapan trase jalur kereta api yang mengalami kemunduran jadwal karena permasalahan pembebasan lahan, dan minimnya pemahaman penanggungjawab program kerjasama (PJPK) terhadap konsep KPBU. Hal ini terjadi karena proyek KA Makassar-Parepare merupakan proyek KPBU pertama yang ditangani oleh Kementerian Perhubungan selaku PJPK, sehingga kesiapan sumber daya manusia dan koordinasi organisasi yang baik sangat diperlukan dalam proses penyiapan proyek KPBU kereta api.
COMPARATIVOS DAS VARIABILIDADES DO CLIMA E DO CONFORTO AMBIENTAL NOS MUNICÍPIOS DE CAMPINA GRANDE E MONTEIRO, PB.
Authors: Mainar de Medeiros Raimundo , Marcelo Falle Saboya Luciano , Vieira de França Manoel , Rodolfo de Araújo Wagner , Cunha Filho Moacyr , Morant de Holanda Romildo , Carlos Montenegro Coutinho Junior João 
Published: December 2021

Os seres humanos reagem diferentemente às condições extremas do tempo e do clima. Verificação da variabilidade mensal dos dados das temperaturas: máximas, média e mínima amplitude térmica, umidade relativa, velocidade e direção do vento, evapotranspiração e evaporação, cobertura de nebulosidade, insolação total, índices pluviométricos e pressão atmosfera do período 1961 a 1990. Esta variabilidade é decorrente do setor urbanização e rural que tem causado muitos impactos no meio ambiente como desmatamento desordenado e sem a reposição da vegetação; movimentos da terra impedindo o escoamento das águas pluviais; impermeabilização do solo por cobertura asfáltica desordenadas; aterramento de rios, riachos, córregos, lagoas; modificações nos ecossistemas; poluição ambiental através da frota automotivo e a verticalização da cidade contribuem para a variabilidade das flutuações dos mínimos e máximos valores referenciados. Tratará dos aspectos da importância do clima nos comparativos das variabilidades do clima e do conforto ambiental nos municípios de Campina Grande e Monteiro, PB no ambiente construído com enfoque para ocupação humana, animal e vegetal, e como pode ser feita a avaliação dos dados climáticos, obtendo-se diretrizes construtivas para ambos os municípios quando da utilização dos dados a serem empregados para construções de edificações e o conforto térmicos entre ser humano, animal e vegetal. Os dados utilizados e analisados ora são benéficos para um município e ora não tem representatividade, principalmente os dados de velocidade e direção do vento para Monteiro, evaporação e evapotranspiração.
Mutlu TÜRKMEN (2018), Beden Terbiyesi Erken Dönem Türk-Spor Politikalarının Sosyo-Politik Temelleri
Authors: SARIYAR SEZAN Canan 
Published: December 2021

MUTLU TÜRKMEN (2018), BEDEN TERBİYESİ ERKEN DÖNEM TÜRK-SPOR POLİTİKALARININ SOSYO-POLİTİK TEMELLERİ
(Ankara: Spor Yayınevi ve Kitabevi, 202 sayfa, ISBN: 978-605-81186-4-5)
Penerapan Teknik Relaksasi Messase Punggung Untuk Menurunkan Nyeri Kepala Pada Pasien Hipertensi
Authors: Latifah Khalimatul , Faradisi Firman 
Published: December 2021

AbstractHypertension is an abnormal levels of blood pressure, which is characterized by a systolic pressure above 140 mmHg and a diastolic pressure above 90 mmHg it occurs in arterial blood vessels that can transport blood from the heart and is able to pump it throughout the tissues, organs of the body that are continuously more than a period. Pain is a state of uncomfortable feelings and pain can also create disturbances in sleep and rest patterns. One of an alternative interventions to reduce neck pain is back messase relaxation. The purpose of the study was to applied back message relaxation therapy to reduce neck pain in patients with hypertension. The method of the scientific study was a case studies with the application of interventions It is done for three days twice a day in the morning and evening and subjects of this case study were two hypertension patients who experienced neck pain. The result show that back messase relaxation was effective in reducing neck pain. Accordingly, the back messase relaxation can be used to reduce neck pain in hypertension patients. Keywords: Back Messase Relaxation; Hypertension; Neck Pain
AbstrakHipertensi merupakan suatu peningkatan tekanan darah yang abnormal, yang di tandai dengan tekanan sistolik di atas 140 mmHg dan tekanan diastolik di atas 90 mmHg yang terjadi di dalam pembuluh darah arteri yang dapat mengangkut darah dari jantung dan mampu untuk memompanya keseluruh jaringan, organ-organ tubuh yang secara terus-menerus yang lebih dari suatu periode. Nyeri adalah suatu keadaan perasaan yang tidak nyaman dan nyeri dapat juga membuat gangguan pada pola tidur dan istirahat. Tindakan untuk menurunkan nyeri kepala salah satunya dengan messase punggung. Messase punggung mampu untuk menurunkan nyeri kepala. Tujuan Karya Tulis Ilmiah ini adalah untuk menggunakan terapi relaksasi messase punggung untuk menurunkan nyeri kepala pada penderita hipertensi. Metode yang di gunakan dalam karya tulis ilmiah ini adalah studi kasus dengan penerapan intervensi yang di lakukan selama tiga hari sebanyak dua kali dalam sehari pada waktu pagi dan sore hari dan subyek studi kasus ini dua klien penderita hipertensi yang mengalami nyeri kepala. Hasil Karya Tulis Ilmiah ini menunjukkan perubahan skala nyeri dan mengatakan nyeri berkurang pada klien I dan II. Kesimpulan dari studi kasus ini menunjukkan messase punggung efektif untuk menurunkan nyeri kepala pada penderita hipertensi. Saran dari penulis di harapkan relaksasi messase punggung ini dapat di gunakan untuk penerapan yang efektif pada penderita hipertensi yang mengalami nyeri kepala..Kata kunci: Hipertensi; Nyeri kepala; Relaksasi messase punggung
Literarure Review Tentang Penerapan Senam Yoga Untuk Mengurangi Kecemasan Ibu Hamil
Authors: Fitriani Dewi Hastutik , Isytiaroh I , Widyastuti Windha 
Published: December 2021

AbstractAnxiety in pregnant women will increase as the time of delivery approaches. One way to reduce this anxiety is by doing yoga exercises. This scientific report was written to describe the implementation of yoga exercise to reduce anxiety in pregnant women based on a literature review. This literature review was constructed by analyzing three articles taken from Google Scholar with “Yoga Exercise”, “Anxiety” and “Pregnancy” as the keywords, in the form of fulltext articles, and published in 2020. The results showed that average anxiety level decreased from 25.75 to 16.92 after doing Yoga Exercises (from the range 6-27). In conclusion, yoga exercise could reduce the anxiety level in pregnant women. Hence, health care providers are expected to be able to implement and teach yoga exercises to reduce anxiety in pregnant women.Keywords: anxiety, pregnancy, yoga exercise
AbstrakKecemasan pada ibu hamil akan meningkat seiring dengan mendekatinya waktu persalinan. Salah satu cara untuk menurunkan kecemasan pada ibu hamil dalam menghadapi persalinan dapat dilakukan dengan senam yoga. Tujuan karya tulis ilmiah ini adalah mengetahui penerapan senam yoga untuk mengurangi kecemasan pada ibu hamil berdasarkan literature review. Metode karya tulis ilmiah yang digunakan adalah literature review dengan jumlah tiga artikel yang diambil dari laman jurnal google scholar dengan kata kunci “Senam Yoga” , “Kecemasan” dan “Kehamilan” berupa artikel fulltex, terbit tahun 2020. Responden dari ketiga artikel berjumlah 86 responden. Hasil dari literature review ketiga artikel menunjukkan bahwa terdapat penurunan rata-rata kecemasan sebelum melakukan senam yoga yaitu 25,75 dan sesudah melakukan senam yoga yaitu 16,92 (dari rentang 6-27). Simpulannya adalah senam yoga dapat menurunkan kecemasan pada ibu hamil. Saran bagi tenaga kesehatan diharapkan agar dapat menerapkan senam yoga untuk menurunkan kecemasan pada ibu hamil.Kata kunci : kecemasan, kehamilan, senam yoga
Literatur Review: Efektifitas Kompres Dinginterhadap Penurunan Intensitas Nyeri Pada Pasien Fraktur Tertutup
Authors: Khasanah Nur , Wirotomo Tri Sakti , Rofiqoh Siti 
Published: December 2021

AbstractFractures cause physiological disturbances, one of which is pain. Pain in fracture patients is caused by muscle spasms. Cold compression is the easiest method to reduce pain. This study identifies cold compresses’ effect in reducing closed fracture patients by finding research articles from Google Scholar. Keywords for the search include “closed fracture”, “pain intensity”, and “cold compress”, published in 2011-2020. Three articles were analyzed. The results showed that 57 total respondents were male (68.09%) and female (31.91%). Before the intervention was 6.72, pain intensity dropped to 3.50 after the intervention with a p-value <0.01. This Literature Review concludes that cold compress therapy is effective in reducing pain among closed fracture patients. Nurses are expected to apply cold compress therapy as an intervention to reduce pain in fracture patients.Keywords: cold compress; pain intensity; closed fracture;
AbstrakFraktur merupakan ancaman potensial maupun aktual terhadap integritas seseorang, sehingga akan mengalami gangguan fisiologis salah satunya respon berupa nyeri. Nyeri pada pasien fraktur disebabkan karena spasme otot. Upaya menurunkan nyeri pada pasien fraktur tertutup dengan cara memberikan terapi kompres dingin. Tujuan dari penulisan ini untuk menggambarkan pengaruh pemberian kompres dingin terhadap nyeri pasien fraktur tertutup. Desain karya tulis ini berupa Literature Review dengan jumlah tiga artikel yang diambil dari laman google scholar dengan kata kunci “fraktur tertutup”, “intensitas nyeri”, dan “kompres dingin”, terbit tahun 2011-2020. Hasil analisa karakteristik responden dari ketiga artikel menunjukkan jumlah responden 57 pasien, sebagian besar laki-laki (68,09%) sedangkan perempuan (31,91%). Nilai rata-rata nyeri sebelum intervensi 6,72 setelah intervensi 3,50 dengan p-value 0,000. Simpulan dari Literature Review ini adalah terapi kompres dingin efektif dalam menurunkan tingkat nyeri pasien fraktur tertutup. Saran bagi perawat diharapkan dapat menerapkan terapi kompres dingin sebagai salah satu intervensi untuk menurunkan nyeri pasien fraktur.Kata kunci:kompres dingin; intensitas nyeri; fraktur tertutup;
Penerapan Terapi Range Of Motion (Rom) Terhadap Peningkatan Kekuatan Otot Pada Pasien Dengan Stroke
Authors: Pratama M. Zulfi , Faradisi Firman , Fajriyah Nuniek Nizmah 
Published: December 2021

Abstract A stroke is an injury to the brain caused by a blockage obstruction of blood flow to the brain. Weakness in the limbs is often found in patients with strokes. Range Of Motion therapy may help to increase the muscle strength that is experencing weakness, avoiding complications from inactivity, such us contractions. This study aims to describe the effect of ROM Therapy in stroke patients with impaired physical mobility. The design of the scientific essay was a case study of two stroke clients who had msucle weakness. A research instrument is an obsevation sheet on the scale of the muscle strength. This case study was conducted for six days of ROM therapy with a frequency of twice a day.The case study result showed that two respondents experienced an increase in muscle strength after ROM therapy. This study concludes that ROM therapy may increase muscle strength among stroke patients. Stroke patient families are expected to assist and support the patient during Range Of Motion exercises.Keywords: Muscle weakness strength, Range Of Motion, Stroke.
Abstrak Stroke merupakan keadaan cidera pada otak yang disebabkan sumbatan atau obstruksi aliran darah menuju otak. Kelemahan pada anggota gerak sering dijumpai pada pasien dengan stroke. Pemberian terapi Range Of Motionbermanfaat untuk meningkatkan kekuatan otot yang mengalami kelemahan, menghindari komplikasi akibat kurang gerak, seperti kontraktur. Penelitian ini bertujuan untuk menggambarkan penerapan terapi ROM pada pasien stroke dengan gangguan mobilitas fisik. Desain karya tulis ilmiah berupa studi kasus pada 2 klien stroke yang mengalami masalah kelemahan otot. Instrumen penelitian berupa lembar observasi mengenai skala kekuatan otot. Studi kasus ini dilakukan selama 6 hari dengan frekuensi 2 kali sehari dengan intervensi penerapan terapi Range Of Motion (ROM). Hasil studi kasus menunjukan masalah gangguan mobilitas fisik yang dialami kedua responden mengalami peningkatan kekuatan setelah dilakukan terapi ROM. Kesimpulan terapi Range Of Motion(ROM) dapat untuk mningkatkan kekuatan otot pada pasien stroke. Saran bagi keluarga diharapkan keluarga untuk selalu melakukan pendampingan saat dilakukaSaran bagi keluarga diharapkan keluarga untuk selalu melakukan pendampingan saat dilakukan implementasi agar dapat menjadi supporting sistem bagi pasien dan dapat mengerti sehingga dapat membantu klien dalam melakukan latihan rentang gerak otot.Kata kunci: Kelemahan kekuatan otot, Range Of Motion, Stroke.
Penerapan Isometric Handgrip Exercisedan Slow Deep Breathing Exercise Untuk Menurunkan Tekanan Darah
Authors: Aisah Nur Marifatun , Rejeki Herni 
Published: December 2021

AbstractHypertension is an increase in blood pressure with systolic above 140 mmHg and diastolic above 90 mmHg. One of the non-pharmacological methods to lower blood pressure is to do isometric handgrip exercise and slow deep breathing exercise. The purpose of this case study is to evaluate blood pressure by implementing isometric handgrip exercise and slow deep breathing exercise toward hypertensive patients within five day of training (twice per day). There were two hipertensive patients involvid in this study. The results of this case study showed that the blood pressure of both patients dropped to normal. The firt patients blood pressure dropped to normal from 160/100 mmHg to 130/80 mmHg after the intervention. Similarly, the second patients blood pressure reduced from 170/100 mmHg to 120/80 mmHg. This study conclusion that the isometric handgrip exercise and slow deep breathing exercise can lower blood pressure.Keywords: Hypertension; Isometric Handgrip; Slow Deep Breathing
AbstrakHipertensi adalah peningkatan tekanan darah dengan sistolik diatas 140 mmHg dan diastolik diatas 90 mmHg.salah satu tindakan nonfarmakologi yang dapat menurunkan tekanan darah adalah dengan melakukan latihan isometric handgrip exercise dan slow deep breathing exercise. Tujuan dilakukannya penerapan studi kasus ini adalah untuk menurunkan tekanan darah dengan menggunakan latihan isometric handgrip exercise dan slow deep breathing exercise pada keluarga dengan hipertensi. Metode yang digunakan adalah dengan penerapan latihan isometric handgrip exercise dan slow deep breathing exercise. Hasil dari studi kasus ini menunjukkan adanya penurunan tekanan darah pada klien I dan II yang disertai dengan penurunan rasa nyeri, klien I dengan tekanan darah 160/100 mmHg turun menjadi 130/80 mmHg dan klien II dengan tekanan darah 170/100 mmHg turun menjadi 120/80 mmHg. Kesimpulan dari penerapan isometric handgrip exercise dan slow deep breathing exercise adalah bahwa penerapan latihan isometric handgrip exercise dan slow deep breathing exercise dapat menurunkan tekanan darah selama 5 hari latihan dengan 2 kali pertemuan setiap harinya.Kata kunci: Hipertensi; Isometric Handgrip; Slow Deep Breathing