bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experiences of increased food insecurity, economic and psychological distress during the COVID-19 pandemic among Supplemental Nutrition Assistance Program-enrolled food pantry clients
Authors: Higashi Robin T , Sood Anubha , Conrado Ana Belen , Shahan Kathryn L , Leonard Tammy , Pruitt Sandi L 
Published: December 2021

AbstractObjective:The COVID-19 pandemic initially doubled the rates of food insecurity across the USA and tripled rates among households with children. Despite the association among food insecurity, chronic disease and psychological distress, narratives depicting the experiences of already food insecure populations are notably underrepresented in the literature. The current study assessed the impact of COVID-19 on clients of a food pantry who were also enrolled in the Supplemental Nutrition Assistance Program (SNAP).Design:A qualitative study probing the effects of the pandemic on daily living, food needs, food buying and food insecurity. Interview transcripts were analysed using a combined deductive and inductive approach.Setting:Interviews were conducted via telephone between May and June of 2020.Participants:Equal numbers of English- and Spanish-speaking clients (n 40 total).Results:Three main findings emerged: (1) the pandemic increased economic distress, such as from job loss or increased utility bills due to sustained home occupancy and (2) the pandemic increased food needs, food prices and food shortages. In combination with economic stressors, this led to greater food insecurity; (3) increased economic stress and food insecurity contributed to increased psychological stress, such as from fear of infection, isolation and children being confined at home.Conclusions:Despite federal legislation and state and local programmes to alleviate food insecurity, COVID-19 exacerbated economic hardship, food insecurity and psychological distress among urban SNAP and food pantry clients. Additional research is needed to identify the most effective policies and programmes to ameliorate the short- and long-term health and economic inequities exacerbated by the pandemic.
Maternal perceptions and concerns about children’s weight status and diet quality: a study among Black immigrant families
Authors: Kengneson Cris-Carelle , Blanchet Rosanne , Sanou Dia , Batal Malek , Phillips Karen P , Giroux Isabelle 
Published: December 2021

AbstractObjective:To identify factors influencing Black immigrant mothers’ perceptions and concerns about child weight and to compare children’s diet quality according to these perceptions and concerns.Design:Mothers’ perceptions and concerns about child weight were assessed with sex-specific figure rating scales and the Child Feeding Questionnaire, respectively. Participants’ weights and heights were measured and characterised using WHO references. Children’s dietary intakes were estimated using a 24-h dietary recall. Children’s diet quality was evaluated using the relative proportion of their energy intake provided by ultra-processed products, which were identified with the NOVA classification. χ2 tests, multivariate logistic regressions and t tests were performed.Setting:Ottawa, Ontario, Canada.Participants:Black immigrant mothers of Sub-Saharan African and Caribbean origin (n 186) and their 6–12-year-old children.Results:Among mothers, 32·4 % perceived their child as having overweight while 48·4 % expressed concerns about child weight. Girls and children with overweight or obesity were significantly more likely to be perceived as having overweight by their mothers than boys and normal-weight children, respectively. Mothers of children living with obesity, but not overweight, were significantly more likely to be concerned about their child’s weight than mothers of normal-weight children. Children’s diet quality did not differ according to mothers’ perceptions and concerns.Conclusions:Children’s gender and weight status were major determinants of perceptions and concerns about child weight among Black immigrant mothers. Including knowledge about mothers’ perceptions and concerns about child weight will help nutrition professionals develop interventions tailored to specific family needs within the context of their cultural backgrounds.
The Geomagnetic Storm Time Response of the Mid Latitude Ionosphere During Solar Cycle 24
Authors: Tariku Yekoye Asmare 
Published: December 2021

AbstractThis paper mainly assesses the geomagnetic storm time response of the Africa, America, Asia and Europe mid latitude ionosphere in relation to the variability of the total electron content during solar cycle 24. This is carried out by considering the vertical total electron content (VTEC) data derived from the Global Positioning System (GPS), the recent International Reference Ionosphere (IRI 2016) and IRI‐Extended to the Plasmasphere (IRI‐Plas 2017) models in different geomagnetic storm days during solar cycle 24 (1 June 2013, 17 March 2015, and 28 May 2017). The effects of the 1 June 2013 and 17 March 2015 (2015 St. Patrick's Day) geomagnetic storms which resulted in intensification and fluctuation of the GPS VTEC variations were significantly enhanced in the European sector. On the other hand, the effect of the storm that occurred on 28 May 2017 was mostly pronounced in the American and Asian sectors. Both models are not able to adequately respond to the effects resulting from the geomagnetic storm. The VTEC calculated by the IRI models also generally decrease on most of the hours when the storm on option is applied during the main and recovery phases. Nevertheless, at the Asian station, the IRI‐Plas 2017 VTEC values tend to increase on most of the hours during the 2015 St. Patrick's Day storm. Moreover, as a result of enhancement of the VTEC, the satellite signal propagation during the positive geomagnetic storms is largely affected by the VTEC fluctuation.
Automated Detection of Antenna Malfunctions in Large‐N Interferometers: A Case Study With the Hydrogen Epoch of Reionization Array
Authors: Storer Dara , Dillon Joshua S. , Jacobs Daniel C. , Morales Miguel F. , Hazelton Bryna J. , Ewall‐Wice Aaron , Abdurashidova Zara , Aguirre James E. , Alexander Paul , Ali Zaki S. , Balfour Yanga , Beardsley Adam P. , Bernardi Gianni , Billings Tashalee S. , Bowman Judd D. , Bradley Richard F. , Bull Philip , Burba Jacob , Carey Steven , Carilli Chris L. , Cheng Carina , DeBoer David R. , de Lera Acedo Eloy , Dexter Matt , Dynes Scott , Ely John , Fagnoni Nicolas , Fritz Randall , Furlanetto Steven R. , Gale‐Sides Kingsley , Glendenning Brian , Gorthi Deepthi , Greig Bradley , Grobbelaar Jasper , Halday Ziyaad , Hewitt Jacqueline N. , Hickish Jack , Huang Tian , Josaitis Alec , Julius Austin , Kariseb MacCalvin , Kern Nicholas S. , Kerrigan Joshua , Kittiwisit Piyanat , Kohn Saul A. , Kolopanis Matthew , Lanman Adam , La Plante Paul , Liu Adrian , Loots Anita , MacMahon David , Malan Lourence , Malgas Cresshim , Martinot Zachary E. , Mesinger Andrei , Molewa Mathakane , Mosiane Tshegofalang , Murray Steven G. , Neben Abraham R. , Nikolic Bojan , Nunhokee Chuneeta Devi , Parsons Aaron R. , Pascua Robert , Patra Nipanjana , Pieterse Samantha , Pober Jonathan C. , Razavi‐Ghods Nima , Riley Daniel , Robnett James , Rosie Kathryn , Santos Mario G. , Sims Peter , Singh Saurabh , Smith Craig , Tan Jianrong , Thyagarajan Nithyanandan , Williams Peter K. G. , Zheng Haoxuan 
Published: December 2021

AbstractWe present a framework for identifying and flagging malfunctioning antennas in large radio interferometers. We outline two distinct categories of metrics designed to detect outliers along known failure modes of large arrays: cross‐correlation metrics, based on all antenna pairs, and auto‐correlation metrics, based solely on individual antennas. We define and motivate the statistical framework for all metrics used, and present tailored visualizations that aid us in clearly identifying new and existing systematics. We implement these techniques using data from 105 antennas in the Hydrogen Epoch of Reionization Array (HERA) as a case study. Finally, we provide a detailed algorithm for implementing these metrics as flagging tools on real data sets.
Circular RNA circRPPH1 promotes breast cancer progression via circRPPH1-miR-512-5p-STAT1 axis
Authors: Huang Yixiang , Zheng Wenfang , Ji Changle , Wang Xuehui , Yu Yunhe , Deng Xiaochong , Zhou Xiqian , Fang Lin 
Published: December 2021

AbstractBreast cancer (BC) is one of the most fatal diseases among women all over the world. Non-coding RNAs including circular RNAs (circRNAs) have been reported to be involved in different aspects during tumorigenesis and progression. In this study, we aimed to explore the biological functions and underlying mechanism of circRPPH1 in BC. Candidate circRNAs were screened in dataset GSE101123 from Gene Expression Omnibus (GEO) database and a differentially expressed circRNA, circRPPH1, was discovered in BC. CircRPPH1 expression was higher in the cancerous tissue compared to paired adjacent tissue. Further in vitro and in vivo experiments indicated that circRPPH1 acted as an oncogene in BC. In addition, circRPPH1 was mainly localized in cytoplasm and played the role of miR-512-5p sponge. By sequestering miR-512-5p from the 3′-UTR of STAT1, circRPPH1 inhibited the suppressive role of miR-512-5p, stabilized STAT1 mRNA in BC and finally affected BC progression. In conclusion, these findings indicated that circRPPH1 acted as an oncogene and regulated BC progression via circRPPH1-miR-512-5p-STAT1 axis, which might provide a potential therapeutic target for BC treatment.
Automated vision screening of children using a mobile graphic device
Authors: Kane Steven A. , Gaspich Mark , Kane Julia , Weitzman Sarah A. , Hofeldt Albert 
Published: December 2021

Abstract
Background/Objective
Can measuring interocular brightness disparity, acuity, and colour vision classify children with amblyopia?

Subjects/Methods
Two hundred eight subjects (3–14 years) were recruited for a prospective, observational protocol to measure interocular brightness disparity, uniocular acuities with and without a pinhole, and colour vision using an iPad. Subjects looked through polarizing filters and chose the brighter of two spaceships to measure interocular brightness disparity. The differential brightness of image pairs was varied through a staircase algorithm until equal brightness was perceived. Acuities and colour vision were tested with tumbling Es and AO-HRR colour plates, respectively. Unilateral amblyopia was later confirmed in two subjects.

Results
Binocular brightness balance on the iPad detected amblyopes with 100% sensitivity and specificity. Using 20/30 as cutoff for normal acuity, 1 of the amblyopes was detected, and non-amblyopes were excluded by visual acuity pinhole testing. The mean difference between iPad and E-Chart visual acuities with pinhole was 0.02 logMAR with limits of agreement from −0.08 to +0.11 logMAR. iPad and printed plates Colour vision testing produced identical results. Testing times were brief and exit pleasure responses were positive. Mean and range testing times for Brightness Sense, Colour vision, and Visual Acuity were 32.7 s (range = 12–63 s), 52.8 min (range = 17–95 s), and 88.75 s (range = 41–188 s), respectively.

Conclusions
Interocular brightness disparity, acuity, and colour vision can be measured in children as young as 3 years old solely through playing a game on a mobile device. Interocular brightness disparity is a sensitive and specific method to detect unilateral amblyopia.
Safety and efficacy of avapritinib in advanced systemic mastocytosis: the phase 1 EXPLORER trial
Authors: DeAngelo Daniel J. , Radia Deepti H. , George Tracy I. , Robinson William A. , Quiery Albert T. , Drummond Mark W. , Bose Prithviraj , Hexner Elizabeth O. , Winton Elliott F. , Horny Hans-Peter , Tugnait Meera , Schmidt-Kittler Oleg , Evans Erica K. , Lin Hui-Min , Mar Brenton G. , Verstovsek Srdan , Deininger Michael W. , Gotlib Jason 
Published: December 2021

AbstractAdvanced systemic mastocytosis (AdvSM) is a rare hematologic neoplasm driven by theKITD816V mutation and associated with poor survival. This phase 1 study (NCT02561988) evaluated avapritinib (BLU-285), a selective KIT D816V inhibitor, in patients with AdvSM. The primary endpoints were the maximum tolerated dose, recommended phase 2 dose and safety of avapritinib. Secondary endpoints included overall response rate and changes in measures of mast cell burden. Avapritinib was evaluated at doses of 30–400 mg once daily in 86 patients, 69 with centrally confirmed AdvSM. Maximum tolerated dose was not reached, and 200 mg and 300 mg daily were studied in dose-expansion cohorts. The most frequent adverse events observed were periorbital edema (69%), anemia (55%), diarrhea (45%), thrombocytopenia (44%) and nausea (44%). Intracranial bleeding occurred in 13% overall, but in only 1% of patients without severe thrombocytopenia (platelets <50 × 109/l). In 53 response-evaluable patients, the overall response rate was 75%. The complete remission rate was 36%. Avapritinib elicited ≥50% reductions in marrow mast cells and serum tryptase in 92% and 99% of patients, respectively. Avapritinib induced deep and durable responses, including molecular remission ofKITD816V in patients with AdvSM, and was well tolerated at the recommended phase 2 dose of 200 mg daily.
Efficacy and safety of avapritinib in advanced systemic mastocytosis: interim analysis of the phase 2 PATHFINDER trial
Authors: Gotlib Jason , Reiter Andreas , Radia Deepti H. , Deininger Michael W. , George Tracy I. , Panse Jens , Vannucchi Alessandro M. , Platzbecker Uwe , Alvarez-Twose Iván , Mital Andrzej , Hermine Olivier , Dybedal Ingunn , Hexner Elizabeth O. , Hicks Lisa K. , Span Lambert , Mesa Ruben , Bose Prithviraj , Pettit Kristen M. , Heaney Mark L. , Oh Stephen T. , Sen Jayita , Lin Hui-Min , Mar Brenton G. , DeAngelo Daniel J. 
Published: December 2021

AbstractAdvanced systemic mastocytosis (AdvSM) is a rare,KITD816V-driven hematologic neoplasm characterized by mast cell infiltration and shortened survival. We report the results of a prespecified interim analysis of an ongoing pivotal single-arm phase 2 trial (no.NCT03580655) of avapritinib, a potent, selective KIT D816V inhibitor administered primarily at a once-daily starting dose of 200 mg in patients with AdvSM (n = 62). The primary endpoint was overall response rate (ORR). Secondary endpoints included mean baseline change in AdvSM–Symptom Assessment Form Total Symptom Score and quality of life, time to response, duration of response, progression-free survival, overall survival, changes in measures of disease burden and safety. The primary endpoint was successfully met (P = 1.6 × 10-9), with an ORR of 75% (95% confidence interval 57–89) in 32 response-evaluable patients with AdvSM who had sufficient follow-up for response assessment, including 19% with complete remission with full or partial hematologic recovery. Reductions of ≥50% from baseline in serum tryptase (93%), bone marrow mast cells (88%) andKITD816V variant allele fraction (60%) were observed. The most frequent grade ≥3 adverse events were neutropenia (24%), thrombocytopenia (16%) and anemia (16%). Avapritinib demonstrated a high rate of clinical, morphological and molecular responses and was generally well tolerated in patients with AdvSM.
Predictors of changes in cerebral perfusion and oxygenation during obstructive sleep apnea
Authors: Zhang Zhongxing , Qi Ming , Hügli Gordana , Khatami Ramin 
Published: December 2021

AbstractObstructive sleep apnea syndrome (OSAS) is a common sleep disorder. Severe OSAS defined as apnea–hypopnea index (AHI) ≥ 30/h is a risk factor for developing cerebro-cardiovascular diseases. The mechanisms of how repetitive sleep apneas/hypopneas damage cerebral hemodynamics are still not well understood. In this study, changes in blood volume (BV) and oxygen saturation (StO2) in the left forehead of 29 newly diagnosed severe OSAS patients were measured by frequency-domain near-infrared spectroscopy during an incremental continuous positive airway pressure (CPAP) titration protocol together with polysomnography. The coefficients of variation of BV (CV-BV) and the decreases of StO2 (de-StO2) of more than 2000 respiratory events were predicted using linear mixed-effect models, respectively. We found that longer events and apneas rather than hypopneas induce larger changes in CV-BV and stronger cerebral desaturation. Respiratory events occurring during higher baseline StO2 before their onsets, during rapid-eye-movement sleep and those associated with higher heart rate induce smaller changes in CV-BV and de-StO2. The stepwise increased CPAP pressures can attenuate these changes. These results suggest that in severe OSAS the length and the type of respiratory event rather than widely used AHI may be better parameters to indicate the severity of cerebral hemodynamic changes.
Higher mucosal antibody concentrations in women with genital tract inflammation
Authors: Sobia Parveen , Pillay Thevani , Liebenberg Lenine J. P. , Sivro Aida , Mansoor Leila E. , Osman Farzana , Passmore Jo-Ann S. , Abdool Karim Quarraisha , Abdool Karim Salim S. , Baxter Cheryl , McKinnon Lyle R. , Archary Derseree 
Published: December 2021

AbstractInflammatory cytokines augment humoral responses by stimulating antibody production and inducing class-switching. In women, genital inflammation (GI) significantly modifies HIV risk. However, the impact of GI on mucosal antibodies remains undefined. We investigated the impact of GI, pre-HIV infection, on antibody isotypes and IgG subclasses in the female genital tract. Immunoglobulin (Ig) isotypes, IgG subclasses and 48 cytokines were measured prior to HIV infection in cervicovaginal lavages (CVL) from 66 HIV seroconverters (cases) and 66 matched HIV-uninfected women (controls) enrolled in the CAPRISA 004 and 008 1% tenofovir gel trials. Pre-HIV infection, cases had significantly higher genital IgM (4.13; IQR, 4.04–4.19) compared to controls (4.06; IQR, 3.90–4.20;p = 0.042). More than one-quarter of cases (27%) had GI compared to just over one-tenth (12%) in controls. Significantly higher IgG1, IgG3, IgG4 and IgM (allp < 0.05) were found in women stratified for GI compared to women without. Adjusted linear mixed models showed several pro-inflammatory, chemotactic, growth factors, and adaptive cytokines significantly correlated with higher titers of IgM, IgA and IgG subclasses (p < 0.05). The strong and significant positive correlations between mucosal antibodies and markers of GI suggest that GI may impact mucosal antibody profiles. These findings require further investigation to establish a plausible biological link between the local inflammatory milieu and its consequence on these genital antibodies.
Clinical significance and biological functions of chemokine CXCL3 in head and neck squamous cell carcinoma
Authors: Guan Jian , Weng Jinru , Ren Qiaosheng , Zhang Chunbin , Hu Liantao , Deng Wenjun , Lu Shizhen , Dong Xinyu , Li Weidong , Li Yue , Wang Weiqun 
Published: December 2021

AbstractCXCL3 plays extensive roles in tumorigenesis in various types of human cancers through its roles in tumor cell differentiation, invasion, and migration. However, the mechanisms of CXCL3 in head and neck squamous cell carcinoma (HNSCC) remain unclear. In our study, multiple databases were used to explore the expression level, prognostic value, and related mechanisms of CXCL3 in human HNSCC through bioinformatic methods. We also performed further experiments in vivo and in vitro to evaluate the expression of CXCL3 in a human head and neck tissue microarray and the underlying effect mechanisms of CXCL3 on the tumor biology of HNSCC tumor cells. The result showed that the expression level of CXCL3 in patients with HNSCC was significantly higher as compared with that in normal tissues (P&lt;0.05). Kaplan–Meier survival analysis demonstrated that patients with high CXCL3 expression had a lower overall survival rate (P=0.038). CXCL3 was further identified as an independent prognostic factor for HNSCC patients by Cox regression analysis, and GSEA exhibited that several signaling pathways including Apoptosis, Toll-like receptor, Nod-like receptor, Jak-STAT, and MAPK signaling pathways may be involved in the tumorigenesis of HNSCC. CAL27 cells overexpressing or HNSCC cells treated with exogenous CXCL3 exhibited enhanced cell malignant behaviors, whereas down-regulating CXCL3 expression resulted in decreased malignant behaviors in HSC4 cells. In addition, CXCL3 may affect the expression of several genes, including ERK1/2, Bcl-2, Bax, STAT3, and NF-κB. In summary, our bioinformatics and experiment findings effectively suggest the information of CXCL3 expression, roles, and the potential regulatory network in HNSCC.
Sexualität und Intimität bei depressiven Erkrankungen
Authors: Ebert Andreas 
Published: December 2021

ZUSAMMENFASSUNG
Gegenstand und Ziel Sexuelle Bedürfnisse und Intimität beeinflussen die Lebensqualität von depressiven Patienten genauso wie die der Allgemeinbevölkerung. Trotz der hohen Prävalenz depressiver Störungen wird dieser Aspekt aus unterschiedlichen Gründen oft zu wenig beachtet. Besonders häufig sind Störungen der Libido bei depressiven Frauen wie Männern, es kann jedoch die ganze Bandbreite sexuellen Erlebens betroffen sein. Neben biologischen, psychologischen und partnerschaftlichen Ursachen für sexuelle Probleme ist insbesondere die pharmakologische Behandlung affektiver Störungen oft selbst Teil des Problems. Verschiedene medikamentöse und adjuvante Strategien können hier erfolgreich eingesetzt werden.
Schlussfolgerung und klinische Relevanz Nicht immer lassen sich sexuelle Nebenwirkungen, sexuelle Störungen oder Partnerschaftskonflikte vollständig verhindern. Dennoch sind ein offener und ehrlicher Kommunikationsstil und eine gründliche Prüfung von möglichen Vorgehensweisen, um dieses zusätzliche Leiden depressiver Patienten zu lindern, möglich. Nicht zuletzt ist eine weitere Erforschung des sexuellen Erlebens und der Intimität im Rahmen von Depressionen dringend erforderlich.
Shiftless inhibits flavivirus replication in vitro and is neuroprotective in a mouse model of Zika virus pathogenesis
Authors: Hanners Natasha W. , Mar Katrina B. , Boys Ian N. , Eitson Jennifer L. , De La Cruz-Rivera Pamela C. , Richardson R. Blake , Fan Wenchun , Wight-Carter Mary , Schoggins John W. 
Published: December 2021

Significance

Flaviviruses are significant human pathogens and emerging infectious disease threats. A screen of interferon-inducible genes revealed Shiftless (SHFL) as a potent antiviral effector, inhibiting all
Flaviviridae
tested, including West Nile, Zika, dengue, yellow fever, and hepatitis C viruses. Mechanistic studies showed that SHFL inhibits viral replication at a point after translation of the incoming genome. In whole-body
Shfl
knockout (KO) mice, compared to wild-type mice, the
Shfl
KO mice were more susceptible to Zika virus. Notably,
Shfl
was uniquely required for controlling replication in the brain and spinal cord, demonstrating an unappreciated neuroprotective role for this effector in vivo. SHFL is a key antiviral effector that specifically inhibits flavivirus genome replication, and
Shfl
protects mice from Zika virus–induced neuropathogenesis.
Sleep promotes the formation of dendritic filopodia and spines near learning-inactive existing spines
Authors: Adler Avital , Lai Cora Sau Wan , Yang Guang , Geron Erez , Bai Yang , Gan Wen-Biao 
Published: December 2021

Significance
Sleep contributes to long-term memory formation after learning, but underlying mechanisms remain unclear. We found that post-learning sleep promoted the formation of dendritic filopodia and spines clustered with learning-inactive existing spines. A fraction of these filopodia was converted into new spines over extended periods of time. These findings provide insights into the role of post-learning sleep in regulating the number and location of new synapses via promoting dendritic filopodial formation.