bluuebunny/crossref_metadata_2025_split huggingface dataset:
UJI STABILITAS FISIK DAN EFEKTIVITAS ANTIBAKTERI PADA PERESEPAN PUYER ERITROMISIN CHEWABLE TERHADAP BAKTERI Escherichia coli DAN Staphylococcus aureus
Authors: Herawati Mutiara , Indrati Oktavia , Romadhonsyah Fitra , Purbaningtias Tri Esti , Dini Sekti Kartika , Rahmadani Yusi , Mardatillah Wahidatun 
Published: January 2025

Intisari
Latar belakang: Eritromisin sering diresepkan untuk pasien pediatrik karena tersedia dalam bentuk tablet kunyah. Pada beberapa kondisi tablet kunyah dibuat puyer untuk meningkatkan kenyamanan pasien dalam mengonsumsi obat. Perubahan bentuk sediaan tablet kunyah menjadi puyer dapat memperluas permukaan obat sehingga berisiko mempengaruhi stabilitas fisik sediaan dan efektivitasnya terhadap suatu bakteri.
Tujuan: Penelitian ini bertujuan untuk mengetahui stabilitas fisik puyer dan efektivitas puyer eritromisin terhadap E. coli dan S. aureus pada hari ke-1 sampai ke-14.
Metode: pengujian ini dilakukan dengan membuat puyer eritromisin dalam dosis 200 mg yang biasa diberikan untuk pasien pneumonia dengan dosis 50 mg/kgBB/hari. Puyer akan diuji stabilitas fisiknya melalui uji organoleptis dan kelembapan. Selanjutnya puyer diuji efektivitasnya menggunakan metode difusi
cakram (Kirby Bauer) dengan mengukur diameter zona hambat puyer eritromisin 25,65 μg yang mengandung eritromisin 15 μg terhadap bakteri E.coli dan S.aureus.
Hasil: pengujian ini dilakukan dengan membuat puyer eritromisin dalam dosis 200 mg yang biasa diberikan untuk pasien pneumonia dengan dosis 50 mg/kgBB/hari. Puyer akan diuji stabilitas fisiknya melalui uji organoleptis dan kelembapan. Selanjutnya puyer diuji efektivitasnya menggunakan metode difusi cakram (Kirby Bauer) dengan mengukur diameter zona hambat puyer eritromisin 25,65 μg yang mengandung eritromisin 15 μg terhadap bakteri E.coli dan S.aureus.
Kesimpulan: stabilitas fisik puyer dan efektivitas puyer terhadap bakteri E.coli dan S.aureus mengalami perubahan antara hari ke-1 hingga hari ke-14. Namun demikian, puyer tetap bersifat stabil secara fisik dan efektif terhadap suatu bakteri.
Kata kunci: eritromisin, puyer, stabilitas fisik, efektivitas
Protection of Muslim Consumers’ Right To Information on Imported Food Without Halal Labeling
Authors: Riana Fatimah Azzahrani  , Retno Wulansari  
Published: January 2025

This study aims to examine the protection of Muslim consumers’ right to information on imported food without halal labels and to investigate the responsibility of business actors for providing such information. Imported food offers a wide variety of options from around the world that can be enjoyed by Muslim consumers. However, not all imported food is guaranteed to be halal, which raises concerns among Muslim consumers. This research adopts a normative juridical approach, utilizing a statutory approach. The findings reveal that legal protection for Muslim consumers regarding the right to information on imported food without halal labels has been pursued by establishing halal product assurance institutions, BPOM supervision, halal certification regulations, and MUI halal certification. Nevertheless, its implementation remains suboptimal. Additionally, business actors have not fulfilled their responsibility to include halal labels on imported products. Consequently, when losses occur, business actors fail to provide compensation for the damages suffered by Muslim consumers.Keywords: Consumer Protection, Halal Label, Imported Food, Responsibility
AbstrakPenelitian ini bertujuan untuk mengkaji perlindungan hak konsumen muslim atas informasi makanan impor tanpa label halal dan untuk mengetahui tanggung jawab pelaku usaha dalam menyediakan informasi tersebut. Makanan impor menawarkan berbagai macam pilihan dari seluruh dunia yang dapat dinikmati oleh konsumen Muslim. Namun, tidak semua makanan impor terjamin kehalalannya, sehingga menimbulkan kekhawatiran di kalangan konsumen Muslim. Penelitian ini menggunakan pendekatan yuridis normatif dengan menggunakan pendekatan perundang-undangan. Temuan penelitian mengungkapkan bahwa perlindungan hukum bagi konsumen muslim terkait hak atas informasi makanan impor tanpa label halal telah diupayakan dengan membentuk lembaga jaminan produk halal, pengawasan BPOM, peraturan sertifikasi halal, dan sertifikasi halal MUI. Namun demikian, implementasinya masih belum optimal. Selain itu, pelaku usaha belum memenuhi tanggung jawabnya untuk mencantumkan label halal pada produk impor. Akibatnya, ketika terjadi kerugian pelaku usaha tidak memberikan ganti rugi atas kerugian yang diderita oleh konsumen muslim.Kata kunci: Perlindungan Konsumen, Label Halal, Pangan Impor, Tanggung Jawab
WITHDRAWN: Pregnant Women’s Knowledge and Beliefs regarding the Affect of Obesity on the Continuation of Breast Feeding
Authors: Alotaibi Jazi Shaydied , AlAnazy Wdad , Mahmoud Fatma zaghloul 
Published: January 2025

Abstract

The full text of this preprint has been withdrawn by the authors in order to comply with an institutional policy on preprints. Therefore, the authors do not wish this work to be cited as a reference.
Diversity of ants on Guabiroba trees (Campomanesia xanthocarpa O. Berg) of Mixed Ombrophilous Forest
Authors: Iasczczaki Rafael Stempniak , Correia Danielly Lisoski , Doline Rodrigo , Holdefer Roberta 
Published: January 2025

Abstract

There are many types of interactions between ants and plants, and many of these are first discovered by the observation and identification of the ants on particular plant species. Therefore, studying the diversity of ants on different strata of a plant species, for example, is indispensable to identify interactions and their ecological implications. In this study we evaluated the diversity of visitor ants on two strata of Guabiroba trees (Campomanesia xanthocarpa O. Berg), a tree species from Mixed Ombrophilous Forest that possess ecological, economical, medicinal, and for food importance. We sampled the ant species from lower plant strata (in the plant surroundings) by collecting them manually in 97 sites; and from higher strata through pitfall traps, suspended in branches and leaves of 117 Guabiroba trees. We identified 30 ant morphospecies on Guabiroba trees (Manual Sobs = 22; Sest = 46,74; Pitfall Sobs = 21; Seat = 21.89) and our results estimated increased ant richness if a higher sampling effort was applied. Nylanderia fulva was the most abundant species, followed by Camponotus crassus, Ca. rufipes, and Ca. melanoticus, which occurred very abundantly, frequently and constantly on Guabiroba trees, acording to the faunal analysis. More than half of the recorded species only occasionally visited Guabiroba trees. Our results indicated an overlap in composition of ant species from both studied strata, suggesting regular visitation of some ants and perhaps interactions between them and the plant. Our study contributes adding information on the ants from Mixed Ombrophilous Forest and ecological relations between Guabiroba trees and their visitor ants.
Characterization of the Sahelian and Guinea Savannah ecosystem of Nigeria based on land surface temperature and normalized difference vegetation index
Authors: An Ping , Aki Ene Emmanuel , Otie Victoria Oko , Isong Isong Abraham , Akpan Joyce Fidelis , Offiong Raphael , Afu Sunday Marcus , Yuanrun Zheng , Haruyuki Fujimaki , Eneji Anthony Egrinya 
Published: January 2025

Abstract

Drought and desertification are expected to increase in Sahelian Africa, where there are significant rainfall deficits and extreme temperatures. This study examined the trends in vegetation and climate variables during the period 1986–2023 in Kano, Katsina and Jigawa states, Nigeria. We used Landsat 5 TM, 7 ETM+ and 8 OLI/TIRS and processed spectral indices with Google earth engine platform. For the pilot site in Kano, the year 2015 had the highest minimum (40.19°C), maximum (43.04 °C) and mean (42.63 °C) land surface temperatures (LST), while 2005 had the lowest of these values. The LST for the three states showed a long-term increase over the study years but the normalized difference vegetation index in 1986 was generally low, being 0.19 in Kano, 0.15 in Katsina and 0.17 in Jigawa states, becoming lower still in 2010. Low vegetation condition index close to 0 was dominant in the three study sites, suggesting typically poor vegetation growth and coverage. Mild to severe drought was noticed in Jigawa state, while Kano and Katsina experienced mild drought. Continuous monitoring of these indices would be necessary to assess the overall health of the vegetation, providing insights into environmental changes and their potential impacts on the ecosystem.
Accident Prevention through Enhanced Visibility Prediction: A Sophisticated Approach Leveraging Machine Learning Techniques
Authors: Ramrakhiani Nikita , Kumar Abhijeet 
Published: January 2025

Abstract

Weather reports are essential for a range of purposes, including pollution control and addressing weather-related issues. They help identify the dispersion of pollutants, enabling effective pollution management. Weather forecasts also aid in preparing for emergencies, optimizing agriculture practices, ensuring safe transportation, and promoting public health. These reports play a vital role in decision-making across sectors, enhancing safety, resilience, and overall well-being. Using machine learning, particularly the logistic regression algorithm, this study demonstrates its efficacy in predicting binary weather events like rain or sunny based on various weather parameters. Through accurate modeling and evaluation, the research highlights the algorithm's potential for practical weather forecasting applications. This research intends to analyze the significance of weather forecasting for advancing our comprehension of Indian weather dynamics and its role in enhancing predictive capabilities to address weather-related challenges effectively. Through our model and analysis, we attempt to predict the visibility index and identify the factors such as pollution, gas emissions, etc which affect visibility in specific regions which impact the number of accidents and mishaps
Identification and validation of mitochondrial dynamics-related genes in patients with acute myocardial infarction-a bioinformatics analysis
Authors: Yue Xiaolin , Wu Jinlei , Shi Xueyun , Xu Youshun , Han Xiaowei , Li Ruijian 
Published: January 2025

Abstract

Recent studies highlight the link between cardiovascular disease and mitochondrial dynamics. This study sought biomarkers of mitochondrial dynamics in acute myocardial infarction (AMI) to guide more precise clinical management. AMI-related datasets (GSE62646 and GSE59867) and 50 mitochondrial dynamics-related genes (MD-RGs) were derived from public databases. Firstly, based on MD-RGs, AMI samples in GSE62646 were classified into high- and low-scoring groups by single-sample gene set enrichment analysis. The differentially expressed genes (DEGs) were incorporated into machine learning algorithms. Subsequent expression level and receiver operating characteristic (ROC) analyses identified biomarkers. Furthermore, the relationship between biomarkers and AMI was analyzed by enrichment analysis, immune infiltration analysis, correlation analysis of m6A regulators. Finally, biomarker expression was verified by reverse transcription quantitative PCR (RT-qPCR). In this study, COX7B and SNORD54 were identified as biomarkers associated with mitochondrial dynamics in AMI. ROC curves showed that two biomarkers could better differentiate between AMI and control samples, and subsequent nomogram created by integrating two biomarkers were highly accurate in predicting AMI. Furthermore, enrichment analysis revealed that co-enrich pathways for COX7B and SNORD54 included “oxidative phosphorylation” and “Notch signaling pathway”. Notably, six m6A regulators (HNRNPC, KIAA1429, METTL3, WTAP, YTHDC1, and YTHDC2) were found to be significantly under-expressed in AMI samples. The RT-PCR demonstrated that the expression levels of COX7B and SNORD54 were significantly downregulated in AMI samples compared to controls. The study recognized COX7B and SNORD54 as biomarkers associated with mitochondrial dynamics in AMI, presenting potential clinical applications that could advance the understanding of AMI management.
Ellipse detection and positioning in complex vision measurement environments
Authors: Song Jin , Zeng Bowei , Ma Jun 
Published: January 2025

Abstract

Ellipses are often widely used as a visual positioning marker. Occluded ellipses in complex backgrounds are difficult to detect and locate accurately. Traditional ellipse detection methods are prone to missed detection and large edge positioning deviations. This greatly affects the accuracy of subsequent algorithms. A single-stage anchor-free ellipse detector is proposed in this paper, which achieves fast and high-precision detection and positioning of ellipses in complex occluded environments. According to the special shape of the ellipse, the attention mechanism is introduced to help the model more accurately locate the area containing the ellipse and pay more attention to useful channel information. Secondly, dynamic upsampling and variable convolution are used to design the decoder of the model to improve the positioning accuracy of the ellipse. Gauss-Wasserstein is used for IoU loss, and the center point deviation loss is modified to optimize the ellipse regression accuracy. Combined with real measurement applications, this paper builds an ellipsoidal sphere dataset for large-scale spatial camera calibration. Experiments on self-built datasets and public datasets show that the performance of the proposed method is better than the state-of-the-art model.
Study on the Influence of Dynamic Performance of Rail Pad on the Vibration Characteristics of E-type Fastener Clip
Authors: Wang Zhixuan , He Zhenxing , Liu Weixing , Xu Tianci , Xu Chang , Bai Yanbo , Zhao Pingrui 
Published: January 2025

Abstract

The issue of E-type fastener clip fracture due to high-frequency vibration has attracted widespread attention, with research focusing on the mechanisms leading to such failures. The rail pad, crucial to the fastener system for elastic vibration damping elastic vibration damping, exhibits significant variations in dynamic performance depending on the material and structure. Currently, there is a lack of studies on how the dynamic performance of the rail pad affects E-type fastener clip vibrations and fractures. To address this, the tests for the dynamic stiffness of rail pads under constant frequency and variable temperature conditions have been conducted using a universal testing machine fitted with a temperature control box, revealing its wide-band dynamic characteristics. These characteristics were represented using the Prony series. A detailed finite element model of the fastener system was developed, incorporating the nonlinear contact relationships among the components and the dynamic performance of rail pads. Frequency response analysis was performed to compare the dynamic steady-state responses of fastener systems with different rail pads. Finally, drop shaft impact tests were simulated to evaluate the vibration acceleration response of E-type fastener clip with various rail pads. The results indicate that the dynamic performance of rail pad significantly affects the vibration characteristics of E-type clips. Among the three rail pads with identical stiffness, the new mesh-type rail pad (NMTRP) demonstrated the best damping energy absorption capability, effectively reducing the vibration acceleration of the E-type Fastener clip.
Hydrogeochemistry and assessment of pollution indices for diagnosing drinking water quality in abandoned mining areas
Authors: Thimotheo Marina , Borba Ricardo Perobelli , Tognoli Francisco Manoel Wohnrath 
Published: January 2025

Abstract

Artisanal mining is responsible for extensive contamination of ecosystems, including humans and animals. Abandoned areas can present environmental problems related with potentially toxic metals and metalloids that are not bio(decomposed). This study focuses on the two-century-old Lavras do Sul Gold District, an Au-Ag-Cu mining area in southern Brazil abandoned 40 years ago. Currently, these areas are inhabited and used for agricultural and pasture activities. Based on chemical analysis of water for human consumption from homemade/private wells collected in two field campaigns, we evaluated the presence, distribution and quantity of potentially toxic elements. Furthermore, the determination of the pollution indices Heavy Metal Pollution Index (HPI) and Heavy Metal Evaluation Index (HEI), helped in the evaluation of potability. The proposed workflow includes hydrogeochemical analysis, mathematical modelling for element speciation, index calculation and spatial interpolation. The hydrogeochemical results indicate that source of anions and cations has influence of the agricultural activity and, to a lesser extent, geological activities. The elements in the highest concentrations are NO3-, Cl- and Cd2+, Pb2+, As(V), Al3+ and Fe2+, which made 70% and 100% of the water samples unsuitable for consumption, respectively from the first and second field campaigns. The analysis of the indices revealed significant discrepancies in potability diagnoses, with the HPI reaching a value 72.1 times higher than the HEI in the same sample. The index that best represented contamination by critical metals in the area was the HPI, as it favors small quantities of elements in defining the weights of these pollution indices.
B7-H3 regulates HK2 expression and promotes the PI3K/AKT/mTOR pathway
Authors: Han Shiyang , Wu Yuantao , Zhang Yan , Zhou Yan , Xia Qiuyan , Wu Yi , Liu Zhanguo , Yang Jing , Shen Ye , Zhou Shuru 
Published: January 2025

Abstract

Background
Lung cancer is the foremost cause of cancer-related mortality globally. B7-H3, an immune checkpoint, not only has immunomodulatory functions but also promotes tumor cell proliferation, drug resistance, metastasis, and aerobic glycolysis. The specific role of B7-H3 in aerobic glycolysis in lung cancer has not yet been elucidated.
Methods
B7-H3 expression was validated in lung cancer tissues and lung cancer cell lines. Overexpression and knockout experiments were conducted in lung cancer cell lines to assess cell proliferation, migration, lactate production, and glucose consumption. The expression of hexokinase 2 (HK2) and the PI3K/Akt/mTOR signaling pathway were analyzed. Additionally, soluble B7-H3 (sB7-H3) along with lactate levels in the plasma of lung cancer patients were measured, and the clinical characteristics were analysed.
Results
B7-H3 was highly expressed in lung cance tissue and lung cancer cell lines, and enhanced the proliferation and migration, along with increased lactate production and glucose consumption rates. Our study also demonstrated that B7-H3 regulates the expression of HK2, thereby promoting the proliferation and migration of lung cancer cells through the PI3K/Akt/mTOR signaling pathway. Furthermore, sB7-H3 levels was postively correlated with the lacte levels in the plasma of lung cancer patients, and high sB7-H3 levels were associated with a poorer prognosis.
Conclusion
The research suggests that B7-H3 affects lung cancer cell proliferation and migration by enhancing aerobic glycolysis via HK2, providing a new perspective for the application of B7-H3 in clinical prognosis and treatment.
Extracellular Vesicles Enhance Osteogenic Differentiation of Mesenchymal Stem Cells without any Chemical Agents
Authors: Anand Ganga , Gopala Srinivas , Urulangodi Madhusoodanan , Komath Manoj 
Published: January 2025

Abstract

The use of extracellular vesicles (EVs) in bone tissue engineering is emerging as a promising alternative strategy to stem cells. For clinical application, EVs must be biomanufactured from suitable source cells, systematically characterized, and validated for their efficacy in bone regeneration. This study focuses on the possibility of this translation using in vitro methods with rat bone marrow stem cells (rBMSCs). Bone marrow was harvested from Wistar rats and cultured using the direct adherence method. The rBMSCs were characterized through trilineage differentiation, flow cytometry, immunofluorescence, and real-time PCR. The optimal isolation method of EVs derived from the rBMSC was investigated. EVs isolated through ultracentrifugation yielded homogeneous EVs with good quality and quantity. The EVs derived from rBMSCs were characterized through Nanoparticle Tracking Analysis, Dynamic Light Scattering, Transmission Electron Microscopy, and Western Blot analysis. The osteogenic differentiation of rBMSCs was evaluated using the isolated EVs, confirmed by the MTT Cell Proliferation Assay and In vitro Osteogenesis Assays. The concentration- and time-dependent enhancement of osteogenic differentiation by rBMSC-derived EVs was also examined. Most importantly, EVs promoted osteogenic differentiation without adding any conventional chemical agents in the culture media. These findings will pave the way for further investigations to link EVs' therapeutic benefits in bone tissue engineering and related applications.
TINGKAT MODAL SOSIAL DALAM PENINGKATAN PENGELOLAAN AIR BERSIH PADA HIPPAM DESA SUMBERAGUNG KEPOHBARU BOJONEGORO
Authors: Rahmawati L Kurnia , Ari Ismu Rini Dwi , Hariyani Septiana 
Published: January 2025

Program penyediaan air minum berbasis masyarakat dikenal sebagai Himpunan Penduduk Pemakai Air Minum, bertujuan memberikan akses air minum kepada rumah tangga di kota maupun perdesaan yang tidak terjangkau oleh layanan Perusahaan Daerah Air Minum. Kurangnya kesadaran pelanggan air dalam pembayaran iuran menjadi hambatan dalam pemenuhan air bersih di Desa Sumberagung. Oleh karena itu, selain memperhatikan modal ekonomi dan sumber daya manusia, modal sosial masyarakat juga menjadi fokus pada peningkatan pengelolaan air bersih. Tujuan penelitian ini adalah mengukur tingkat modal sosial masyarakat Desa Sumberagung dalam peningkatan pengelolaan air bersih. Analisis dilakukan menggunakan metode Social Network Analysis dengan tiga variabel: tingkat partisipasi, kerapatan dan sentralitas, dengan memanfaatkan software UCINET Versi 6.528. Dengan teknik pengumpulan data primer yaitu observasi dan angket yang dibagikan kepada pengguna air sebanyak 685 KK dengan diambil sampel sebanyak 88 KK menggunakan rumus Taro Yamane. Studi ini menemukan bahwa nilai partisipasi masyarakat tergolong rendah, nilai kerapatan dan sentralitas masyarakat tergolong tinggi. Hal ini menunjukkan meskipun individu dalam masyarakat tersebut cenderung berinteraksi secara intensif dan saling terkait, mereka tidak aktif secara langsung dalam pengelolaan air bersih. Masyarakat cenderung mengikuti kelembagaan internal di desa, sehingga dikategorikan dalam tingkat modal sosial Bonding Social Capital.