bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance and environmental accounting of nutrient cycling models to estimate nitrogen emissions in agriculture and their sensitivity in life cycle assessment
Authors: Andrade Edilene Pereira , Bonmati August , Esteller Laureano Jimenez , Montemayor Erica , Vallejo Assumpcio Anton 
Published: February 2021

Abstract
Purpose
Several models are available in the literature to estimate agricultural emissions. From life cycle assessment (LCA) perspective, there is no standardized procedure for estimating emissions of nitrogen or other nutrients. This article aims to compare four agricultural models (PEF, SALCA, Daisy and Animo) with different complexity levels and test their suitability and sensitivity in LCA.

Methods
Required input data, obtained outputs, and main characteristics of the models are presented. Then, the performance of the models was evaluated according to their potential feasibility to be used in estimating nitrogen emissions in LCA using an adapted version of the criteria proposed by the United Nations Framework Convention on Climate Change (UNFCCC), and other relevant studies, to judge their suitability in LCA. Finally, nitrogen emissions from a case study of irrigated maize in Spain were estimated using the selected models and were tested in a full LCA to characterize the impacts.

Results and discussion
According to the set of criteria, the models scored, from best to worst: Daisy (77%), SALCA (74%), Animo (72%) and PEF (70%), being Daisy the most suitable model to LCA framework. Regarding the case study, the estimated emissions agreed to literature data for the irrigated corn crop in Spain and the Mediterranean, except N2O emissions. The impact characterization showed differences of up to 56% for the most relevant impact categories when considering nitrogen emissions. Additionally, an overview of the models used to estimate nitrogen emissions in LCA studies showed that many models have been used, but not always in a suitable or justified manner.

Conclusions
Although mechanistic models are more laborious, mainly due to the amount of input data required, this study shows that Daisy could be a suitable model to estimate emissions when fertilizer application is relevant for the environmental study. In addition, and due to LCA urgently needing a solid methodology to estimate nitrogen emissions, mechanistic models such as Daisy could be used to estimate default values for different archetype scenarios.
On the asymptotic behavior of the Douglas–Rachford and proximal-point algorithms for convex optimization
Authors: Banjac Goran , Lygeros John 
Published: February 2021

AbstractBanjac et al. (J Optim Theory Appl 183(2):490–519, 2019) recently showed that the Douglas–Rachford algorithm provides certificates of infeasibility for a class of convex optimization problems. In particular, they showed that the difference between consecutive iterates generated by the algorithm converges to certificates of primal and dual strong infeasibility. Their result was shown in a finite-dimensional Euclidean setting and for a particular structure of the constraint set. In this paper, we extend the result to real Hilbert spaces and a general nonempty closed convex set. Moreover, we show that the proximal-point algorithm applied to the set of optimality conditions of the problem generates similar infeasibility certificates.
Influence of Process Conditions on the Local Solidification and Microstructure During Laser Metal Deposition of an Intermetallic TiAl Alloy (GE4822)
Authors: Rittinghaus Silja-Katharina , Zielinski Jonas 
Published: February 2021

Abstract
Temperature-time cycles are essential for the formation of microstructures and thus the mechanical properties of materials. In additive manufacturing, components undergo changing temperature regimes because of the track- and layer-wise build-up. Because of the high brittleness of titanium aluminides, preheating is used to prevent cracking. This also effects the thermal history. In the present study, local solidification conditions during the additive manufacturing process of Ti-48Al-2Cr-2Nb with laser metal deposition (LMD) are investigated by both simulation and experimental investigations. Dependencies of the build-up height, preheating temperatures, process parameters and effects on the resulting microstructure are considered, including the heat treatment. Solidification conditions are found to be dependent on the build height and thus actual preheating temperature, process parameters and location in the melt pool. Influences on both chemical composition and microstructure are observed. Resulting differences can almost be balanced through post heat treatment.
Cortisol circadian rhythm and jet-lag syndrome: evaluation of salivary cortisol rhythm in a group of eastward travelers
Authors: Paragliola Rosa Maria , Corsello Andrea , Troiani Eliana , Locantore Pietro , Papi Giampaolo , Donnini Giulia , Pontecorvi Alfredo , Corsello Salvatore Maria , Carrozza Cinzia 
Published: February 2021

Abstract
Purpose
The activity of the hypothalamus–pituitary–adrenal axis plays a crucial role as an endogenous stress-reactive system. Lifestyle and work often interfere with the endogenous circadian rhythms and can modify the physiological patterns of stress-hormones secretion, including cortisol. We evaluated the cortisol circadian rhythm in the “jet-lag syndrome” that is the most known condition associated with the desynchronization of the circadian rhythm.

Methods
To assess the modifications of cortisol secretion after a long-haul flight, we compared baseline and post-travel salivary cortisol rhythm in a group of 28 healthy eastward travelers (from the U.S.A. or Canada to Italy). The salivary samples were collected about 1 week before the departure at 11 p.m. on day 0 and at 8 a.m., 12 a.m. (midday) and 11 p.m. on day 1 (R0). The same samples were obtained after the landing, the day they flew back home (R1).

Results
Statistical analysis showed a significant difference between R0 and R1 for each sample considered (p < 0.005). In particular, the post-travel salivary cortisol levels detected at 11 p.m. both on day 0 and on day 1, were significantly higher than at baseline. Post-travel morning salivary cortisol levels were lower compared with basal rhythm and increased during the morning, reaching the acrophase at 12 a.m.

Conclusions
In eastward travelers, crossing more than five time zones, the cortisol circadian rhythm after the return to the East “remained behind,” being synchronized with the West time. This impaired cortisol secretion can contribute to the pathogenesis of the jet-lag syndrome.
The clinical aspects of pituitary tumour genetics
Authors: Dénes Judit , Korbonits Márta 
Published: February 2021

Abstract
Background
Pituitary tumours are usually benign and relatively common intracranial tumours, with under- and overexpression of pituitary hormones and local mass effects causing considerable morbidity and increased mortality. While most pituitary tumours are sporadic, around 5% of the cases arise in a familial setting, either isolated [familial isolated pituitary adenoma, related to AIP or X-linked acrogigantism], or in a syndromic disorder, such as multiple endocrine neoplasia type 1 or 4, Carney complex, McCune–Albright syndrome, phaeochromocytoma/paraganglioma with pituitary adenoma, DICER1 syndrome, Lynch syndrome, and USP8-related syndrome. Genetically determined pituitary tumours usually present at younger age and show aggressive behaviour, and are often resistant to different treatment modalities.

Subject
In this practical summary, we take a practical approach: which genetic syndromes should be considered in case of different presentation, such as tumour type, family history, age of onset and additional clinical features of the patient.

Conclusion
The identification of the causative mutation allows genetic and clinical screening of relatives at risk, resulting in earlier diagnosis, a better therapeutic response and ultimately to better long-term outcomes.
Evaluation of AQP4/TRPV4 Channel Co-expression, Microvessel Density, and its Association with Peritumoral Brain Edema in Intracranial Meningiomas
Authors: Faropoulos Konstantinos , Polia Afroditi , Tsakona Chrisi , Pitaraki Eleanna , Moutafidi Athanasia , Gatzounis George , Assimakopoulou Martha 
Published: February 2021

AbstractApart from VEGF-A pathway activation, the existence of peritumoral edema (PTBE) in meningiomas has been correlated with the expression levels of water transporter aquaporin 4 (AQP4). A novel cooperation of AQP4 with the transient receptor potential isoform 4 (TRPV4), a polymodal swelling-sensitive cation channel, has been proposed for regulating cell volume in glial cells. We investigated AQP4/TRPV4 channel co-expression in meningiomas along with the neovascularization of tumors and associate with PTBE. Immunohistochemical staining for AQP4 and TRPV4 expression was quantitatively analyzed in semi-serial sections of archival tissue from 174 patients. Microvessel density was expressed as microvessel count (MVC). PTBE was measured and edema index (EI) was assessed in 23 patients, based on magnetic resonance images (MRI) whereas mRNA levels of AQP4 and TRPV4 were evaluated in these patients using quantitative real-time PCR. High AQP4 was associated with lower–tumor grade (p < 0.05). AQP4 and TRPV4 were correlated in benign (WHO, grade I) (p < 0.0001) but not in high-grade (WHO, grades II and III) meningiomas (p > 0.05). AQP4/TRPV4 levels were independent of EI and MVC (p > 0.05). In contrast, EI was correlated to MVC (p = 0.02). AQP4/TRPV4 co-expression was detected in both edematous and non-edematous meningiomas. However, most of tumors with larger edema (EI ≥ 2) demonstrated increased levels of AQP4 and TRPV4. Importantly, peri-meningioma tissue of edematous meningiomas demonstrated significantly increased expression for AQP4 (p = 0.007) but not for TRPV4 (p > 0.05) compared with the main tumor. AQP4 and TRPV4 expression is rather associated with a response to vasogenic edema of meningiomas than with edema formation.
Quality of life, symptoms and dietary habits in oncology outpatients with malnutrition: A cross-sectional study
Authors: Sonneborn-Papakostopoulos Mira , Dubois Clara , Mathies Viktoria , Heß Mara , Erickson Nicole , Ernst Thomas , Huebner Jutta 
Published: February 2021

AbstractCancer-related malnutrition has a high prevalence, reduces survival and increases side effects. The aim of this study was to assess oncology outpatients and risk of malnutrition. Reported symptoms and quality of life (QoL) in patients found to be at risk of malnutrition or malnourished were compared to patients without malnutrition. Using a standardized questionnaire, the European Organization for Research and Treatment of Cancer Questionnaire for Quality of Life and the Mini Nutritional Assessment (MNA), patients in an outpatient cancer clinic undergoing chemotherapy treatment at a German University Hospital were assessed for nutrition, risk of malnutrition and quality of life. Based on the MNA, 39 (45.9%) patients were categorized as malnourished or at risk for malnutrition. Loss of appetite (n = 37.6%, p < 0.001) and altered taste sensation (n = 30,3%, p < 0.001) were the symptoms most frequently associated with reduced food intake. Patients with risk of malnutrition scored lower on the global health status (n = 48.15%, p = 0.001). Side effects of cancer treatments lead to a higher risk of malnutrition and as a consequence lower QoL. These side effects should be addressed more efficiently in cancer care.
The Influence of Moral Character Attributes on Adolescent Life Satisfaction: the Mediating Role of Responsible Behavior
Authors: Zhou Zheng , Shek Daniel T. L. , Zhu Xiaoqin , Lin Li 
Published: February 2021

AbstractIn this pioneering study, we examined the influence of moral character attributes and responsible behavior on adolescent life satisfaction, as well as the mediating role of adolescents’ responsible behavior in the influence of moral character attributes on life satisfaction in 2,474 adolescents in Hong Kong. We used a 25-item measure to assess moral character attributes, a 15-item measure to assess responsible behavior, and the 5-item Satisfaction with Life Scale to assess life satisfaction. Factor analyses using confirmatory factor analyses provided support for the factorial validity of the measures of adolescent moral character attributes, responsible behavior, and life satisfaction. Consistent with our hypotheses, moral character attributes positively predicted adolescents’ responsible behavior as well as life satisfaction, and adolescents’ responsible behavior positively predicted life satisfaction. Separate analyses using PROCESS and combined analysis using SEM via Mplus showed that adolescents’ responsible behavior mediated the influence of moral character attributes on adolescent life satisfaction. The present findings highlight the importance of moral character on adolescent well-being and support the positive youth development approach in the field.
Stabilization of the Hinge Region of Human E-selectin Enhances Binding Affinity to Ligands Under Force
Authors: Cao Thong M. , King Michael R. 
Published: February 2021

Abstract
Introduction
E-selectin is a member of the selectin family of cell adhesion molecules expressed on the plasma membrane of inflamed endothelium and facilitates initial leukocyte tethering and subsequent cell rolling during the early stages of the inflammatory response via binding to glycoproteins expressing sialyl LewisX and sialyl LewisA (sLeX/A). Existing crystal structures of the extracellular lectin/EGF-like domain of E-selectin complexed with sLeX have revealed that E-selectin can exist in two conformation states, a low affinity (bent) conformation, and a high affinity (extended) conformation. The differentiating characteristic of the two conformations is the interdomain angle between the lectin and the EGF-like domain.

Methods
Using molecular dynamics (MD) simulations we observed that in the absence of tensile force E-selectin undergoes spontaneous switching between the two conformational states at equilibrium. A single amino acid substitution at residue 2 (serine to tyrosine) on the lectin domain favors the extended conformation.

Results
Steered molecular dynamics (SMD) simulations of E-selectin and PSGL-1 in conjunction with experimental cell adhesion assays show a longer binding lifetime of E-selectin (S2Y) to PSGL-1 compared to wildtype protein.

Conclusions
The findings in this study advance our understanding into how the structural makeup of E-selectin allosterically influences its adhesive dynamics.
They ought to do it too: Understanding effects of social information on donation behavior and mood
Authors: van Teunenbroek Claire , Bekkers René , Beersma Bianca 
Published: February 2021

AbstractSocial information, providing potential donors with information about the donation amount given by earlier donors, is often applied as an intervention in online donation contexts. It has been suggested that social information informs others about the most common (descriptive norm) or appropriate (injunctive norm) behavior, and that these perceived social norms explain its effects. We present evidence from a preregistered online experiment testing to what extent perceived social norms mediate effects of social information on charitable giving. In addition, we examine whether social information affects donors’ moods. A positive mood after donating is important to avoid negative side effects of a nudge like social information. We argue that social information increases social pressure to donate in a certain way and therefore decreases donors’ moods. In an experiment among British citizens (n = 1029), we manipulated descriptive and injunctive social information. We show that injunctive social information, mentioning the appropriate donation amount, increases donation amounts (10%) and donors’ moods (10%). Contrary to earlier research, merely stating descriptive social information did not affect the donation behavior or mood. We found no evidence that social information affects giving behavior or mood via perceived social norms. Our findings how different types of social information affect charitable giving are important for fundraisers or policy makers aiming to increase charitable behavior.
Digital image processing methods for the evaluation of optical anisotropy effects in tempered architectural glass using photoelastic measurements
Authors: Dix S. , Müller P. , Schuler C. , Kolling S. , Schneider J. 
Published: February 2021

AbstractIn the present paper, optical anisotropy effects in architectural glass are evaluated using digital image processing. Hereby, thermally toughened glass panes were analyzed quantitatively using a circular polariscope. Glass subjected to externally applied stresses or residual stresses becomes birefringent. Polarized light on birefringent materials causes interference colors (iridescence), referred to as anisotropies, which affect the optical appearance of glass panes in building envelopes. Thermally toughened glass, such as toughened safety glass or heat strengthened glass, show these iridescences due to thermally induced residual stress differences. RGB-photoelastic full-field methods allow the quantitative measurement of anisotropies, since the occurring interference colors are related to the measured retardation values. By calibrating the circular polariscope, retardation images of thermally toughened glass panes are generated from non-directional isochromatic images using computer algorithms. The analysis of the retardation images and the evaluation of the anisotropy quality of the glass is of great interest in order to detect and sort out very low quality glass panes directly in the production process. Therefore, in this paper retardation images are acquired from different thermally toughened glass panes then different image processing methods are presented and applied. It is shown that a general definition of exclusion zones, e.g. near edges is required prior to the evaluation. In parallel, the limitations in the application of first-order statistical and threshold methods are presented. The intend of the investigation is the extension of the texture analysis based on the generation of Grey Level Co-occurrence Matrices, where the spatial arrangement of the retardation values is considered in the evaluation. For the first time, the results of textural features of different glass pane formats could be compared using reference areas and geometry factors. By reduction of the original image size, the computation time of textural analysis algorithms could be remarkably speeded up, while the textural features remained the same. Finally, the knowledge gained from these investigations is used to determine uniform texture features, which also includes the pattern of anisotropy effects in the evaluation of thermally toughened glass. Together with a global evaluation criterion this can now be implemented in commercial anisotropy measurement systems for quality control of tempered architectural glass.
Wirklichkeit und Unwirklichkeit bei Georg Trakl
Authors: Hillenbrand Rainer 
Published: February 2021

ZusammenfassungTrakl konfrontiert ein materialistisches und ein idealistisches Wirklichkeitskonzept, um die Alltagsrealität als defizient zu kritisieren und auf poetische Weise eine geistige Gegenwirklichkeit orphischer Innerlichkeit zu gewinnen. Er benutzt dazu in Anlehnung an antike und christliche Vorbilder eine traditionelle Bildlichkeit, wonach der Tod als Schattenwelt, das Leben als Traum oder Theaterspiel erscheint, und eine in sich stimmige Symbolik. Zuletzt aber scheitert auch diese rein subjektive Sinnsuche der Erinnerung an bessere Zeiten an der unheilbaren Sinnlosigkeit der sozialen und kulturellen Gegenwart.
Entropies and volume growth of unstable manifolds
Authors: ZANG YUNTAO 
Published: February 2021

AbstractLet f be a
$C^2$
diffeomorphism on a compact manifold. Ledrappier and Young introduced entropies along unstable foliations for an ergodic measure

$\mu $
. We relate those entropies to covering numbers in order to give a new upper bound on the metric entropy of

$\mu $
in terms of Lyapunov exponents and topological entropy or volume growth of sub-manifolds. We also discuss extensions to the

$C^{1+\alpha },\,\alpha>0$
, case.
Air contamination of households versus hospital inpatient rooms occupied by severe acute respiratory coronavirus virus 2 (SARS-CoV-2)–positive patients
Authors: Munoz-Price L. Silvia , Rivera Frida , Ledeboer Nathan 
Published: February 2021

AbstractThe household setting has some of the highest coronavirus disease 2019 (COVID-19) secondary-attack rates. We compared the air contamination in hospital rooms versus households of COVID-19 patients. Inpatient air samples were only positive at 0.3 m from patients. Household air samples were positive even without a COVID-19 patient in the proximity to the air sampler.
Surgical considerations during cochlear implantation: the utility of temporal bone computed tomography
Authors: Jun Beomcho , Song Sunwha 
Published: February 2021

AbstractObjectiveThis paper describes the construction of portals for electrode placement during cochlear implantation and emphasises the utility of pre-operative temporal bone three-dimensional computed tomography.MethodsTemporal bone three-dimensional computed tomography was used to plan portal creation for electrode insertion.ResultsPre-operative temporal bone three-dimensional computed tomography can be used to determine the orientation of temporal bone structures, which is important for mastoidectomy, posterior tympanotomy and cochleostomy, and when using the round window approach.ConclusionIt is essential to create appropriate portals (from the mastoid cortex to the cochlea) in a step-by-step manner, to ensure the safe insertion of electrodes into the scala tympani. Pre-operative three-dimensional temporal bone computed tomography is invaluable in this respect.
Development of Hybrid Prandtl–Ishlinskii and Constitutive Models for Hysteresis of Shape-Memory-Alloy-Driven Actuators
Authors: Shakiba Saeid , Ayati Moosa , Yousefi-Koma Aghil 
Published: February 2021

SUMMARY
Prandtl–Ishlinskii (PI) model has an excellent compromise to characterize an asymmetric saturated hysteresis behavior of shape-memory-alloy (SMA)-driven systems, but it cannot consider thermomechanical relations between components of SMA-driven systems. On the other hand, constitutive models are composed of these relations, but their precision needs to be improved. In this paper, PI model is proposed to boost constitutive models in two cases. In the first case, PI model is used to characterize martensite volume fraction (MVF) called hybrid model. In the second case, the model is applied as a regulator in the output of a constitutive model called PI-based output (PIO) regulator. Due to simplicity and ability of Liang–Rogers (LR) model in transformation phases, it is considered as an MVF in the original constitutive model. The performance of both proposed models is compared with the original LR-based constitutive model. Unknown parameters of all three models are identified using genetic algorithm in MATLAB Toolbox. The performance of the three models is investigated at three different frequencies of

\[\frac{{2\pi }}{8}\]

,

\[\frac{{2\pi }}{{15}}\]

, and

\[\frac{{2\pi }}{{30}}\]

Hz because the excitation frequency changes the hysteresis behavior. Results show that the proposed hybrid model keeps the precision of the original constitutive model at different frequencies. In addition, the proposed PIO model shows the best performance to predict hysteresis behavior at different frequencies.