bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological intervention with victims of prison violence: a systematic literature review
Authors: Conde Ana Rita , Souto Teresa , Almeida Ana Maria 
Published: April 2021

Introducción: La victimización penitenciaria ha sido el foco de atención de la comunidad científica con estudios que indican una alta prevalencia y efectos negativos en la salud mental y en la reintegración social de los presidiarios. Sin embargo, existe poca información sobre las intervenciones, por lo que es relevante obtener datos confiables sobre estrategias de intervención que busquen mitigar sus consecuencias y ofrecer apoyo a las víctimas.
Método: Revisión sistemática (RS) mediante el método PRISMA. La investigación se realizó en 10 bases de datos electrónicas y el proceso de recolección y análisis de datos fue realizado por dos investigadores independientes.
Resultados: Se incluyeron cinco publicaciones, tres estudios cuantitativos y dos artículos teóricos, aunque ninguno se centra específicamente en la intervención con personas sometidas a victimización penitenciaria. Esta limitadamente se aborda y analiza teóricamente a lo largo de la discusión.
Conclusión: Existen pocas publicaciones sobre intervención con víctimas de victimización penitenciaria y las existentes no enfocan específicamente la intervención acerca de este tipo de victimización. Sin embargo, se obtuvieron pistas importantes para ser incluidas en futuras propuestas de intervención. Existe consenso en cuanto a la necesidad de adoptar modelos de intervención validados empíricamente, refiriéndose a la Terapia Cognitivo Conductual (TCC), específicamente al Tratamiento Informado por Trauma (TIT).
Background: Prison victimization has been the focus of attention by the scientific community with studies that indicate a high prevalence and negative effects on mental health and social reintegration of prisoners. However, there is few information on intervention responses, so it is relevant to obtain reliable data about intervention strategies that seeks to mitigate its consequences and provide support to victims.
Method: Systematic review (SR) using the PRISMA method. The research was carried out in 10 electronic databases and the data collection and analysis process carried out by two independent researchers.
Results: Five publications were included, three quantitative studies and two theoretical articles although none specifically focuses on intervention with individuals subject to prison victimization. This feature is addressed and theoretically analysed throughout the discussion
Conclusion: There are few publications on intervention with victims of prison victimization and existing ones do not focus on specific intervention in the context of this type of victimization. However, important guidelines were obtained to be included into future intervention proposals. There is a consensus regarding the need to adopt empirically validated intervention models, referring to the Cognitive Behavior Therapy (CBT), specifically the Trauma-Informed Treatment(TIT).
The Mediator Role of Use of Emotion in the Association between Personality Traits and Workaholism
Authors: Sayan İlknur 
Published: April 2021

Este estudio examinó el papel mediador del componente de uso de la emoción (UoE), de la Escala de inteligencia emocional, en la relación entre extraversión (EX) y conciencia dentro de los Cinco Grandes factores de personalidad, y las dimensiones de trabajar en exceso (WE) y trabajar compulsivamente de la Escala holandesa de adicción al trabajo. Junto con este objetivo, se recopilaron datos del personal sanitario, en su mayoría enfermeras, que trabajaba en hospitales privados que prestan servicios en Estambul. Los hallazgos indicaron que WE tuvo un efecto directo no significativo sobre EX (β = −0.358; p > .05), mientras que el efecto indirecto de WE sobre EX a través de UoE fue significativo (β = 0.147; p < .05). Este estudio revela que UoE actúa como un mediador completo en el efecto de WE sobre EX.
This study examined the mediator role of Use of Emotion (UoE) component of Emotional Intelligence (EI) Scale in the relationship between Extraversion (EX) and Conscientiousness (CO) within the Big Five (BF) personality factors, and the dimensions of Working Excessively (WE) and Working Compulsively (WC) of Dutch Work Addiction Scale (DUWAS). Along with this aim, data were collected from healthcare staff, most of who were nurses, working at private hospitals serving in İstanbul. The findings indicated that Working Excessively (WE) had a non-significant direct effect on Extraversion (EX) (β = -.358; p > .05) while the indirect effect of Working Excessively (WE) on Extraversion (EX) through Use of Emotion (UoE) was significant (β = .147; p < .05). This study revealed that Use of Emotion (UoE) acted as a full mediator in the effect of Working Excessively (WE) on Extraversion (EX).
GÉNÉRATIONS IMBRIQUÉES, RESSOURCES NATURELLES ET QUALITÉ OPTIMALE DES DROITS DE PROPRIÉTÉ
Authors: Croutzet Alexandre 
Published: April 2021

Dans une économie parfaitement concurrentielle dans laquelle une ressource naturelle renouvelable est exploitée, la qualité optimale des droits de propriété correspond-elle toujours à des droits complets ou existe-t-il des situations dans lesquelles des droits partiellement définis et/ou partiellement protégés sont optimaux ? C’est la question à laquelle cet article se propose de répondre. En d’autres termes, cet article examine les mérites des droits de propriété partiels dans une économie avec ressource naturelle renouvelable par ailleurs parfaitement concurrentielle. La qualité des droits de propriété est définie comme la proportion de la ressource sur laquelle des droits sont définis et protégés; le reste de la ressource étant en accès libre. Identifier les situations où des droits de propriété partiels peuvent être optimaux est important pour les décideurs. En effet, les droits de propriété sur les ressources renouvelables sont généralement difficiles et coûteux à définir et à protéger parfaitement. Dans une économie décentralisée parfaitement concurrentielle avec ressource naturelle renouvelable et générations imbriquées, nous montrons que des institutions optimales peuvent se traduire par des droits de propriété partiels sur un stock de ressource. L’absence de droits de propriété conduit à une surexploitation, mais l’appropriation privée complète du stock de ressource peut conduire à une suraccumulation de la ressource. En d’autres termes, quand les ressources sont surexploitées en raison d’institutions trop faibles, les renforcer est nécessaire, mais la distance à des institutions optimales peut être plus courte qu’on ne le croit communément.
SPATIAL PRICE TRANSMISSION AND ASYMMETRIC ADJUSTMENT: THE CASE OF LOCAL AND IMPORTED RICE IN TOGO
Authors: Lanie Tomgouani 
Published: April 2021

In this paper, we have investigated the extent and the speed of adjustment of six domestic markets of imported rice and the local market of processed rice in Togo to rice prices change on the global market and how the local market of paddy and the imported rice markets respond respectively to prices change in the processed rice and on the central market of imported rice Lomé and test for asymmetry in the adjustment process using both standard and threshold cointegration tests. Symmetric and asymmetric error correction models with respect to the linear and threshold cointegration relationships between markets pairings are estimated to investigate short-run prices dynamics.
Results indicate that prices for the global to local markets pairings are cointegrated with relatively low price transmission elasticities. Prices on the imported rice markets in Togo are also cointegrated (when Lomé is considered as the central market). Threshold cointegration tests reveal that in the long-run, the local market of paddy adjusts asymmetrically to prices change in the processed rice and there is asymmetric adjustment of domestic markets of Cinkassé and Lomé to prices change on the global market. Except for Amégnran market, the four other domestic markets of imported rice adjust also asymmetrically to rice prices change on the central market of Lomé. In the short-run, there is asymmetric adjustment only between the global market and the imported rice markets of Lomé and Cinkassé. Among imported rice prices dynamics in Togo, only Cinkassé market adjust asymmetrically to prices change on the central market of Lomé. The results imply that oligopolistic middlemen in rice marketing in Togo are more sensitive and react quickly when rice prices change on the global market tends to squeeze their margins than changes that stretch them.
ARIMA Modelling and Forecasting of COVID-19 Daily Confirmed/Death Cases: A Case Study of Nigeria
Authors: Didi Essi Isaac , Kingdom Nwuju , Harrison Etuk Ette 
Published: April 2021

Aims: The aim of this work is to develop suitable ARIMA models which can be sued to forecast daily confirmed/death cases of COVID-19 in Nigeria. This is subject to developing the model, checking them for suitability and carrying out eight months forecast, and making recommendations for the Nigerian Health sector.
Study Design: The study used daily confirmed and death cases of COVID-19 in Nigeria.
Methodology: This work covers times series data on the on the daily confirmed/death cases of COVID-19 in Nigeria, obtained from the Nigerian Centre for Disease Control (NDCD) from 21 March 2020 to 5 May 2020, covering a total of 51 data points. This work is geared towards developing a suitable Autoregressive Integrated Moving Average (ARIMA) models which can be used to forecast total daily confirmed/death cases of COVID-19 in Nigeria. Two adequate subset ARIMA (2, 2, 1) and AR (1) models for the confirmed/death cases, respectively, is fitted and discussed
Results: A forecast of 239 days – from 6th May 2020 to 31 December 2020 was conducted using the fitted models and we observed that the COVID19 data has an upward trend and is best forecasted within a short period.
Conclusion: Critical investigation into the rate of spread of COVID-19 pandemic has shown that, that the daily confirmed cases as well as death cases of the disease tends to follow an upward trend. This work aimed at developing a suitable ARIMA models which can be used to fit a most appropriate subsets to statistically forecast the actual number of confirmed cases as well as death cases of COVID-19 recorded in Nigeria for a period of 8 months.
Process Development of Protein Therapeutics
Authors: Huang Yao‐ming , Bowes Brian , Yang Tzung‐Horng , Thomas James N. , Guhan S. Sam , Pettit Dean K. 
Published: April 2021

AbstractThe application of recombinant DNA technology to the production of protein therapeutics has undergone tremendous progress over the past decades. Considerable scientific effort has been devoted to developing robust processes that produce large amounts of complex proteins with the desired product quality attributes. An overview of the contributions from the four major disciplines working in concert to deliver these processes and methods will be covered. This article will discuss some of the tools, methods, and approaches used to produce, purify, formulate, and analyze the drugs of modern biotechnology. Future trends in each of the disciplines will also be presented.
Multiple Sclerosis
Authors: Pitts William J. , Dyckman Alaric J. 
Published: April 2021

AbstractSeveral new medicines have been approved or entered development for the treatment of Multiple Sclerosis (MS) in the past few years. The sphingosine‐1‐phosphate (S1P) modulator fingolimod was the first FDA approved oral disease modifying therapy for MS, and it has inspired a number of additional agents directed at this clinically validated target. Fumarates (e.g. dimethyl fumarate), dihydroorotate dehydrogenase inhibitors (e.g. teriflunomide) and other agents which decrease lymphocyte proliferation (e.g. cladribine) represent additional clinically validated therapeutic approaches. While the mechanisms of action for these new agents may not be fully defined, they have demonstrated a good degree of efficacy in the treatment of relapsing forms of MS. It is of interest to note that biologic agents which target CD20 on B cells have also shown significant efficacy in the treatment of MS. This, in turn, has spurred MS clinical trials with Bruton's Tyrosine Kinase (BTK) inhibitors, which also act on B cell pathways. The introduction of each of these newer agents still requires careful consideration of the risk–benefit for individual patients, but has also set a higher bar in the treatment of MS for subsequent agents, as evidenced by the discontinuation of several agents in late stage clinical trials. This higher bar has also pushed some historic agents to second or third line agents. This speaks to an overall advancement in the treatment of MS, and provides hope for further advances in therapeutic options.
A Brief Primer on Project Leadership, Project Management, and Cross‐functional Teams
Authors: Myers Michael R. 
Published: April 2021

Abstract
This article is intended to provide the reader a general primer on the general approach that pharmaceutical, biotech, and most recently academic drug discovery and development centers are deploying to conduct R&D work. Additionally, for the interested reader, a select collection of leading resources introducing key concepts and best practices in project management, project leadership, execution, and quality decision‐making are included throughout.
Energy Conversion in Single‐Crystal‐to‐Single‐Crystal Phase Transition Materials
Authors: Zheng Yongshen , Jia Xiaodi , Li Kai , Xu Jialiang , Bu Xian‐He 
Published: April 2021

AbstractSingle‐crystal‐to‐single‐crystal (SCSC) phase transitions are direct structural evolutions of crystalline materials in the solid state without the damage of ordering in the crystal lattice. These multidimensional SCSC phase transition materials are responsive to multiple external stimuli (heat, light, mechanical force, electricity, etc.), and have therefore demonstrated promising applications in many fields such as sensors, actuators, artificial muscles, soft robotics, and energy harvesting. The directionality and cooperativity of intermolecular interactions in crystal structures together with a sustained and long‐range dynamics, and the fact that they can operate at high frequency, enable fast and efficient energy conversion processes in SCSC phase transition materials. In this review, the SCSC phase transition materials are analyzed by dividing them into different types of energy transformation, from the point of view of different stimuli that initiate and drive the phase transition, including the thermo‐, photo‐, electric‐, and mechanic‐induced energy transformation, and the dimensionality dependent characteristics in these processes are presented. Moreover, the state‐of‐the‐art design and fabrication of the SCSC phase transition materials as well as the mechanisms of their energy conversion processes are discussed. Finally, the challenges and future potentials are also discussed.
Supramolecular Cylinders Target Bulge Structures in the 5′ UTR of the RNA Genome of SARS‐CoV‐2 and Inhibit Viral Replication**
Authors: Melidis Lazaros , Hill Harriet J. , Coltman Nicholas J. , Davies Scott P. , Winczura Kinga , Chauhan Tasha , Craig James S. , Garai Aditya , Hooper Catherine A. J. , Egan Ross T. , McKeating Jane A. , Hodges Nikolas J. , Stamataki Zania , Grzechnik Pawel , Hannon Michael J. 
Published: April 2021

AbstractThe untranslated regions (UTRs) of viral genomes contain a variety of conserved yet dynamic structures crucial for viral replication, providing drug targets for the development of broad spectrum anti‐virals. We combine in vitro RNA analysis with molecular dynamics simulations to build the first 3D models of the structure and dynamics of key regions of the 5′ UTR of the SARS‐CoV‐2 genome. Furthermore, we determine the binding of metallo‐supramolecular helicates (cylinders) to this RNA structure. These nano‐size agents are uniquely able to thread through RNA junctions and we identify their binding to a 3‐base bulge and the central cross 4‐way junction located in stem loop 5. Finally, we show these RNA‐binding cylinders suppress SARS‐CoV‐2 replication, highlighting their potential as novel anti‐viral agents.
Zwitterion‐Based Hydrogen Sulfide Nanomotors Induce Multiple Acidosis in Tumor Cells by Destroying Tumor Metabolic Symbiosis
Authors: Wan Mimi , Liu Zhiyong , Li Ting , Chen Huan , Wang Qi , Chen Tiantian , Tao Yingfang , Mao Chun 
Published: April 2021

AbstractDestruction of tumor metabolism symbiosis is an attractive cancer treatment method which targets tumor cells with little harm to normal cells. Yet, a single intervention strategy and poor penetration of the drug in tumor tissue result in limited effect. Herein, we propose a zero‐waste zwitterion‐based hydrogen sulfide (H2S)‐driven nanomotor based on the basic principle of reaction in human body. When loaded with monocarboxylic acid transporter inhibitor α‐cyano‐4‐hydroxycinnamic acid (α‐CHCA), the nanomotor can move in tumor microenvironment and induce multiple acidosis of tumor cells and inhibit tumor growth through the synergistic effect of motion effect, driving force H2S and α‐CHCA. Given the good biosafety of the substrate and driving gas of this kind of nanomotor, as well as the limited variety of nanomotors currently available to move in the tumor microenvironment, this kind of nanomotor may provide a competitive candidate for the active drug delivery system of cancer treatment.
Immediate Implant With Provisionalization and Soft Tissue Grafting After 4‐Year Follow‐Up
Authors: de Siqueira Glaudemir Reinaldo Cavalcanti , Tavares José Rodolfo , Pedrosa Ricardo Ferreira , de Siqueira Rafael Amorim Cavalcanti , Fernandes Gustavo Vicentis de Oliveira 
Published: April 2021

IntroductionThis paper presents a case report of immediate implant placement (IIP) with a provisionalization technique to restore function and esthetics with follow‐up after 4 years.Case PresentationMinimally traumatic extraction was performed with IIP, soft‐tissue grafting, and immediate provisional crown. Six months after optimal healing, the patient was submitted to an esthetic restorative work through veneers in lithium disilicate. Fourteen‐month and 4‐year follow‐up visits revealed stability of the peri‐implant soft‐tissues with peri‐implant health status, with the evaluation of the pink and white esthetic score, yielding to mean scores, respectively, in 14 months of 11.62 ± 2.07 (pink esthetic score [PES]) and 18.25 ± 1.46 (PES/white esthetic score [WES]) and in 4 years of 11.0 ± 1.32 (PES) and 17.62 ± 0.65 (PES/WES). Intraoral digital radiographs showed minimal crestal bone level changes throughout the follow‐up period. Thus, IIP is a sensitive technique procedure, and a 3D implant position is crucial for success.ConclusionImmediate implant with grafting to fill the gap and soft tissue augmentation led to less horizontal changes and stable mucosal margin, and immediate provisionalization helped to maintain soft tissue architecture, and proper case selection is key for clinical success.
Chemical Composition, Antibacterial Screening and Cytotoxic Activity of Chiliadenus antiatlanticus (Asteraceae) Essential Oil
Authors: El Yaagoubi Mohamed , Ortiz Sergio , Mechqoq Hicham , Cavaleiro Carlos , Lecsö‐Bornet Marylin , Rodrigues Maria João , Custódio Luísa , El Mousadik Abdelhamid , Grougnet Raphaël , El Aouad Noureddine , Msanda Fouad , Kritsanida Marina 
Published: April 2021

AbstractThe chemical composition and in vitro antibacterial and cytotoxic activities of the essential oil (EO) of Chiliadenus antiatlanticus (Emb. & Maire) Gómiz, an asteraceous species endemic to the southwest of Morocco, were investigated. The EO yield was 1.07±0.28 %, twenty‐seven metabolites were identified representing more than 96.4 % of the total composition. Camphor (35.7 %) and derivatives, borneol (4.9 %) and camphene (4.2 %) together with intermedeol (19.9 %), α‐pinene (15.5 %) and (E)‐pinocarveol (4.1 %) were the major constituents. An antibacterial activity was noticed against 24 strains (all Gram‐positive) out of 71 at MICs values=100 μg/mL. The EO also showed significant toxicity towards liver HepG2 (55.8 % of cell viability) and melanoma B16 4A5 (41.6 % of cell viability) tumor cell lines at 100 μg/mL.
Binding Mode Characterization of Osteopontin on Hydroxyapatite by Solution NMR Spectroscopy
Authors: Holzinger Julian , Kotisch Harald , Richter Klaus W. , Konrat Robert 
Published: April 2021

AbstractExtracellular matrix glycoproteins play a major role in bone mineralization and modulation of osteogenesis. Among these, the intrinsically disordered protein osteopontin (OPN) is associated with the inhibition of formation, growth and proliferation of the bone mineral hydroxyapatite (HAP). Furthermore, post‐translational modifications like phosphorylation can alter conformations and interaction properties of intrinsically disordered proteins (IDPs). Therefore, the actual interaction of OPN with a HAP surface on an atomic level and how this interaction is affected by phosphorylation is of great interest. Here, we study the interaction of full‐length OPN on the surface of suspended HAP nanoparticles by solution NMR spectroscopy. We report the binding modes of this IDP and provide evidence for the influence of hyperphosphorylation on the binding character and an explanation for the differing roles in biomineralization. Our study moreover presents an easy and suitable option to measure interaction of nanoparticles in a stable suspension with full‐length proteins.
Small‐scale hypoxic cultures for monitoring the spatial reorganization of glycolytic enzymes in Saccharomyces cerevisiae
Authors: Yoshimura Yuki , Hirayama Reina , Miura Natsuko , Utsumi Ryotaro , Kuroda Kouichi , Ueda Mitsuyoshi , Kataoka Michihiko 
Published: April 2021

AbstractAt normal oxygen concentration, glycolytic enzymes are scattered in the cytoplasm of Saccharomyces cerevisiae. Under hypoxia, however, most of these enzymes, including enolase, pyruvate kinase, and phosphoglycerate mutase, spatially reorganize to form cytoplasmic foci. We tested various small‐scale hypoxic culture systems and showed that enolase foci formation occurs in all the systems tested, including in liquid and on solid media. Notably, a small‐scale hypoxic culture in a bench‐top multi‐gas incubator enabled the regulation of oxygen concentration in the media and faster foci formation. Here, we demonstrate that the foci formation of enolase starts within few hours after changing the oxygen concentration to 1% in a small‐scale cultivation system. The order of foci formation by each enzyme is tightly regulated, and of the three enzymes, enolase was the fastest to respond to hypoxia. We further tested the use of the small‐scale cultivation method to screen reagents that can control the spatial reorganization of enzymes under hypoxia. An AMPK inhibitor, dorsomorphin, was found to delay formation of the foci in all three glycolytic enzymes tested. These methods and results provide efficient ways to investigate the spatial reorganization of proteins under hypoxia to form a multienzyme assembly, the META body, thereby contributing to understanding and utilizing natural systems to control cellular metabolism via the spatial reorganization of enzymes.