bluuebunny/crossref_metadata_2025_split huggingface dataset:
Precision mouse models of Yars/dominant intermediate Charcot‐Marie‐Tooth disease type C and Sptlc1/hereditary sensory and autonomic neuropathy type 1
Authors: Hines Timothy J. , Tadenev Abigail L. D. , Lone Museer A. , Hatton Courtney L. , Bagasrawala Inseyah , Stum Morgane G. , Miers Kathy E. , Hornemann Thorsten , Burgess Robert W. 
Published: December 2021

AbstractAnimal models of neurodegenerative diseases such as inherited peripheral neuropathies sometimes accurately recreate the pathophysiology of the human disease, and sometimes accurately recreate the genetic perturbations found in patients. Ideally, models achieve both, but this is not always possible; nonetheless, such models are informative. Here we describe two animal models of inherited peripheral neuropathy: mice with a mutation in tyrosyl tRNA‐synthetase, YarsE196K, modeling dominant intermediate Charcot‐Marie‐Tooth disease type C (diCMTC), and mice with a mutation in serine palmitoyltransferase long chain 1, Sptlc1C133W, modeling hereditary sensory and autonomic neuropathy type 1 (HSAN1). YarsE196K mice develop disease‐relevant phenotypes including reduced motor performance and reduced nerve conduction velocities by 4 months of age. Peripheral motor axons are reduced in size, but there is no reduction in axon number and plasma neurofilament light chain levels are not increased. Unlike the dominant human mutations, the YarsE196K mice only show these phenotypes as homozygotes, or as compound heterozygotes with a null allele, and no phenotype is observed in E196K or null heterozygotes. The Sptlc1C133W mice carry a knockin allele and show the anticipated increase in 1‐deoxysphingolipids in circulation and in a variety of tissues. They also have mild behavioral defects consistent with HSAN1, but do not show neurophysiological defects or axon loss in peripheral nerves or in the epidermis of the hind paw or tail. Thus, despite the biochemical phenotype, the Sptlc1C133W mice do not show a strong neuropathy phenotype. Surprisingly, these mice were lethal as homozygotes, but the heterozygous genotype studied corresponds to the dominant genetics seen in humans. Thus, YarsE196K homozygous mice have a relevant phenotype, but imprecisely reproduce the human genetics, whereas the Sptlc1C133W mice precisely reproduce the human genetics, but do not recreate the disease phenotype. Despite these shortcomings, both models are informative and will be useful for future research.
Nurses’ coping strategies during and after an adult in‐hospital resuscitation attempt: A scoping study
Authors: Blomquist Michael , Lasiter Sue 
Published: December 2021

AbstractAimA scoping study was conducted to identify and synthesise literature about nurse coping strategies during and after cardiopulmonary resuscitations (CPRs).BackgroundNurses frequently engage in CPR events that often lead to patient deaths thereby negatively impacting nurses’ mental and physical health compromising patient safety. Little research has been conducted to explore coping strategies nurses use during and after a CPR event.DesignArksey and O’Malley's framework was used to guide the review process and PRISMA‐ScR checklist for reporting the study.MethodsA comprehensive search (January 1, 1996 – August 1, 2021) using ProQuest, PsychINFO, CINAHL and PubMed databases to locate peer‐reviewed publications that met the study's inclusion criteria. We included publications of data collected from nurses who experienced a non‐simulated adult CPR event in an acute or critical care hospital setting. Lazarus and Folkman's Ways of Coping Checklist, based on the transactional theory of stress and coping, was used to guide data analysis and categorise and label the coping strategies used by nurses.ResultsThe search returned 2689 articles, and nine articles comprised the sample after excluding duplicates, titles, abstracts and full‐text articles not meeting the inclusion criteria. Nine articles were reviewed to identify the coping strategies used by nurses during and after a CPR event. These strategies were grouped into eight categories.ConclusionWhen resuscitation was successful, the experience carried little to no stress. The coping strategy most often used during a resuscitation attempt was planful problem solving. The coping strategies used after a failed resuscitation attempt were planful problem solving and seeking social support. Nurses reported that debriefing sessions were not desirable venues for discussing post‐resuscitation stress.Relevance to clinical practiceThe provision of support by employers and colleagues must be intentionally planned and offered to nurses exposed to the stress induced by unsuccessful attempts at CPR.
Inhibition of monoacylglycerol lipase restrains proliferation, migration, invasion, tumor growth and induces apoptosis in cervical cancer
Authors: Wang Chao , Li Zhoulei , Zhong Linlin , Chen Youguo 
Published: December 2021

AbstractAimCervical cancer is one of common diseases among women. There are limited therapies for patients with metastatic or recurrent cervical cancer. This study sought to explore the role of monoacylglycerol lipase (MAGL), an important metabolic enzyme, in cervical cancer progression.MethodsIn in vitro experiments, MAGL expression was inhibited by si‐MAGL or JZL184 in cervical cancer cells. Quantitative real‐time polymerase chain reaction and western blotting were performed to measure the expression of target molecules. Proliferation of cervical cancer cells was assessed by CCK‐8 and colony formation assays. Apoptosis and cell cycle progression were evaluated by flow cytometry. The migration and invasion were detected by transwell assay. The in vivo tumor growth was detected in nude mice. TUNEL was utilized to observe apoptotic cells in tumor tissues.ResultsMAGL was upregulated in cervical cancer tissues and cells. Further, MAGL inhibition suppressed the growth of cervical cancer cells in vitro and in vivo. In addition, apoptosis and G1‐phase cell cycle arrest were induced by MAGL knockdown. MAGL silencing‐mediated upregulation of Bax and cleaved caspase‐3, and downregulation of Bcl‐2 was responsible for triggering apoptosis. More importantly, the migration and invasion of cervical cancer cells were restrained by MAGL depletion.ConclusionsMAGL drives the progression of cervical cancer, which can be a promising candidate to identify effective therapy for cervical cancer.
Anne Conway’s Exemplary Engagement with Origenist Thought
Authors: Kempson E. S. 
Published: December 2021

AbstractThis article contributes to the historical, theological, and philosophical study of Anne Conway and Origen while also proposing a methodology for theologians interested in drawing on their thought constructively. It evaluates Anne Conway’s use of the theology of Origen in her treatise, The Principles of the Most Ancient and Modern Philosophy, comparing it with her only definitely known printed source of Origen’s ideas, A Letter of Resolution concerning Origen. It draws out Conway’s little‐known theological thinking, building on and engaging with the extant Conway scholarship (most notably Sarah Hutton’s ‘Origen and Anne Conway’) which tends to be more philosophically‐oriented. The result substantially modifies Hutton’s conclusions through a closer theological engagement with both Origen and Conway, making more precise Conway’s relationship with the Origenist tradition in England. In the process, foundational commitments and driving concerns in Conway’s thought are identified and the method of her engagement with Origen is uncovered. The final section speaks particularly to systematicians, presenting a practical method for engaging with the thought of Origen, or any other ‘heterodox’ theologian, or one of a different confession from the practicing theologian. Further engagement with Conway’s own thought is also recommended.
Untimely Reopening? Increase in the Number of New COVID‐19 Cases After Reopening in One Brazilian State
Authors: Sobiech Pellegrini Izabela 
Published: December 2021

AbstractSanta Catarina was one of the first Brazilian states to allow businesses to reopen on 22 April 2020. I apply the synthetic control method to evaluate the impact of the reopening on incidence of daily COVID‐19 cases in Santa Catarina, including 17 Brazilian states in the donor pool. Conclusions about causality between the government measures and the infection spread can be made, although with caution, given the setup of a natural experiment and not actually randomly assigned treatment. The results are robust and show that the reopening leads to a faster spread of the virus, causing between 13.8% and 50% of all infections recorded in the following weeks. This study corroborates the recommendation for policies limiting circulation of people as a means to mitigate the spread of novel infectious diseases.
Bronchopulmonary dysplasia
Authors: Schmidt Alexander R. , Ramamoorthy Chandra 
Published: December 2021

AbstractBronchopulmonary dysplasia is the most frequent adverse outcome of prematurity. Before implementation of antenatal steroids and surfactant therapy, bronchopulmonary dysplasia was mostly characterized by fibrotic, scarred, and hyper‐inflated lungs due to pulmonary injury following mechanical ventilation and oxygen toxicity. With advances in neonatal medicine, this “old” bronchopulmonary dysplasia has changed to a “new” bronchopulmonary dysplasia characterized by an arrest in lung growth, leading to alveolar simplification and pulmonary vascular dysangiogenesis. While the old definition was based on the need for oxygen supplementation at a postnatal age of 28 days or at a corrected gestational age of 36 weeks, the newer definition looks at the mode of respiratory support required (eg, invasive versus noninvasive) and is then graded as mild, moderate, or severe. Patients with bronchopulmonary dysplasia may present with significantly impaired pulmonary function, reactive airway disease, or exercise intolerance. Over time, these patients may develop asthma or chronic obstructive pulmonary disease. The most serious long‐term complication is the development of pulmonary vascular disease and pulmonary hypertension. Medical treatment often includes diuretics, steroids, bronchodilators, or oxygen supplementation and in the presence of pulmonary hypertension medication to decrease the pulmonary vascular resistance. Perioperative anesthetic risk is increased in children with pulmonary hypertension. These patients might require additional diagnostic imaging and plans for increased resource allocation such as postoperative intensive care admission.
Exploring cognitive dissonance in the correctional nursing experience
Authors: Cukale‐Matos Sarah , Champion Jane D. 
Published: December 2021

AbstractObjectiveCorrectional nurses navigate conflict between custody and caring. Balance is needed between healthcare and security priorities. This study explores the unique nature of nursing practice within correctional settings to inform interventions reducing stress, enhancing coping and mitigating cognitive dissonance among these nurses.DesignQualitative, semi‐structured interviews.SamplePurposive sampling of nurses practicing in a correctional facility in the Southwestern United States.ResultsThematic analyses identified six themes describing the experiences of nurses in the correctional facility. The themes, “We have a sense of purpose,” “We don't trust each other,” “We want respect,” “We experience unique stress,” “It changes who you are,” and “We try to leave it all there,” describe the need for interventions providing debriefing opportunities, strengthening of relationships with corrections personnel, reflection and stress reduction to ameliorate the potential for cognitive dissonance.ConclusionsCorrectional nurses in this study perceived a strong sense of purpose and a desire for respect. They are challenged by relationships with both correctional staff and inmates and perceived a change in who they are due to practice in this challenging environment. Measurable, evidence‐based stress relief interventions such as mindfulness practices, reflection interventions, physical activity, prayer and meditation are indicated to address these challenges.
Exogenous citric acid enhances drought tolerance in tobacco (Nicotiana tabacum)
Authors: Xie H. , Bai G. , Lu P. , Li H. , Fei M. , Xiao B.‐G. , Chen X.‐J. , Tong Z.‐J. , Wang Z.‐Y. , Yang D.‐H. 
Published: December 2021

ABSTRACT

Organic acids play a pivotal role in improving plant response to long‐term drought stress. External application of organic acids has been reported to improve drought resistance in several species. However, whether organic acids have similar effects in tobacco remains unknown. A screening study of the protective function of organic acids in tobacco and understanding the underlying molecular mechanism would be useful in developing a strategy for drought tolerance.

Several physiological and molecular adaptations to drought including abscisic acid, stomatal closure, reactive oxygen species homeostasis, amino acid accumulation, and drought‐responsive gene expression were observed by exogenous citric acid in tobacco plants.

Exogenous application of 50 mm citric acid to tobacco plants resulted in higher chlorophyll content, net photosynthesis, relative water content, abscisic acid content and lower stomatal conductance, transpiration and water loss under drought conditions. Moreover, reactive oxygen species homeostasis was better maintained through increasing activity of antioxidant enzymes and decreasing hydrogen peroxide content after citric acid pretreatment under drought. Amino acids involved in the TCA cycle accumulated after external application of citric acid under drought stress. Furthermore, several drought stress‐responsive genes also dramatically changed after application of citric acid.

These data support the idea that external application of citric acid enhances drought resistance by affecting physiological and molecular regulation in tobacco. This study provides clear insights into mechanistic details of regulation of amino acid and stress‐responsive gene expression by citric acid in tobacco in response to drought, which is promising for minimizing growth inhibition in agricultural fields.
Overexpression of IgG2 in patients resembling IgG4‐related disease with normal IgG4
Authors: Lecuit Mathilde , Aucouturier Pierre , Abbas Aicha , Cadranel Jacques , Silvain Christine , Berthelot Jean‐Marie , Fauchais Anne‐Laure , Loubet Paul , Bachmeyer Claude , Montravers Françoise , Dossier Antoine , Nunes Hilario , Cervera Pascale , Coppo Paul 
Published: December 2021

AbstractIgG4‐Related Disease (IgG4‐RD) results from tissue infiltration by IgG4‐expressing plasma cells and lymphocytes, leading to fibrosis and organomegaly. Clinical presentation is remarkably variable according to organ involvement, and high IgG4 serum concentration, initially considered a diagnostic hallmark of IgG4‐RD, tends to be forgone as an indispensable criterion for its diagnosis; it can indeed be absent in some patients, highlighting the diversity of presentation of this dysimmune condition. Nevertheless, elevation of IgG4 serum concentration in suggestive settings remains an argument in favour of IgG4‐RD, and while other IgG subclasses can be elevated, this biological feature lacks any diagnostic value. We retrospectively studied 9 patients (5 females, 4 males, 31–81 years old) for whom a diagnosis of IgG4‐RD had been considered, based on clinical, imaging or histological criteria, but appeared to display abnormally high serum IgG2 while IgG4 levels were normal. Increased serum IgG1 in one case and increased IgG3 in another one were also noticed. Immunohistochemical analyses of intracellular immunoglobulins could be performed on tissue lymph node biopsies from 2 patients, which demonstrated strong infiltration with IgG2‐expressing plasma cells. Thus, overexpression of IgG2 subclass may highlight cases of dysimmune disorders resembling IgG4‐RD, although the disease trigger might be different, notably infectious. We suggest measuring all serum IgG subclass levels in patients with features consistent with IgG4‐RD.
Remote, proactive, telephone based management of toxicity in outpatients during adjuvant or neoadjuvant chemotherapy for early stage breast cancer: pragmatic, cluster randomised trial
Authors: Krzyzanowska Monika K , Julian Jim A , Gu Chu-Shu , Powis Melanie , Li Qing , Enright Katherine , Howell Doris , Earle Craig C , Gandhi Sonal , Rask Sara , Brezden-Masley Christine , Dent Susan , Hajra Leena , Freeman Orit , Spadafora Silvana , Hamm Caroline , Califaretti Nadia , Trudeau Maureen , Levine Mark N , Amir Eitan , Bordeleau Louise , Chiarotto James A , Elser Christine , Husain Juhi , Laferriere Nicole , Rahim Yasmin , Robinson Andrew G , Vandenberg Ted , Grunfeld Eva 
Published: December 2021

AbstractObjectiveTo evaluate the effectiveness of remote proactive management of toxicities during chemotherapy for early stage breast cancer.DesignPragmatic, cluster randomised trial.Setting20 cancer centres in Ontario, Canada, allocated by covariate constrained randomisation to remote management of toxicities or routine care.ParticipantsAll patients starting adjuvant or neoadjuvant chemotherapy for early stage breast cancer at each centre. 25 patients from each centre completed patient reported outcome questionnaires.InterventionsProactive, standardised, nurse led telephone management of common toxicities at two time points after each chemotherapy cycle.Main outcome measuresThe primary outcome, cluster level mean number of visits to the emergency department or admissions to hospital per patient during the whole course of chemotherapy treatment, was evaluated with routinely available administrative healthcare data. Secondary patient reported outcomes included toxicity, self-efficacy, and quality of life.ResultsBaseline characteristics of participants were similar in the intervention (n=944) and control arms (n=1214); 22% were older than 65 years. Penetration (that is, the percentage of patients who received the intervention at each centre) was 50-86%. Mean number of visits to the emergency department or admissions to hospital per patient was 0.91 (standard deviation 0.28) in the intervention arm and 0.94 (0.40) in the control arm (P=0.94); 47% (1014 of 2158 patients) had at least one visit to the emergency department or a hospital admission during chemotherapy. Among 580 participants who completed the patient reported outcome questionnaires, at least one grade 3 toxicity was reported by 48% (134 of 278 patients) in the intervention arm and by 58% (163 of 283) in the control arm. No differences in self-efficacy, anxiety, or depression were found. Compared with baseline, the functional assessment of cancer therapy trial outcome index decreased by 6.1 and 9.0 points in the intervention and control participants, respectively.ConclusionsProactive, telephone based management of toxicities during chemotherapy did not result in fewer visits to the emergency department or hospital admissions. With the rapid rise in remote care because of the covid-19 pandemic, identifying scalable strategies for remote management of patients during cancer treatment is particularly relevant.Trial registrationClinicalTrials.govNCT02485678.
Sustained positive behaviour change of wounded, injured and sick UK military following an adaptive adventure sports and health coaching recovery course
Authors: Sutton Rebecca J , Kay C W P , McKenna J , Kaiseler M 
Published: December 2021

IntroductionA rising trend has occurred in the physical and mental health challenges faced by recovering UK service personnel. To support these individuals, bespoke inclusive multiactivity and adventurous training courses (MAC) have been developed. This study investigated the MAC’s influence on participants’ ability to sustain day-to-day changes that facilitate positive mental health and psychological need satisfaction.MethodsThe 146 UK service personnel who participated in this study attended a five-day MAC 12 months ago. To investigate how the supportive experience influenced participants’ lives, quantitative and qualitative data were collected via an online survey. Open-ended questioning and abductive analysis were conducted to understand mechanisms, influential aspects of the course and positive behaviour change.ResultsPositive behaviour changes were reported by 74% of the respondents. These changes align with positive psychological well-being (98%). Impactful elements of the course experienced by participants mostly aligned with the three basic psychological needs of autonomy (34%), competence (36%) and relatedness (61%).ConclusionsRecovery support programmes that encompass health coaching adventurous activities, such as the MAC, can initiate long-term positive behaviour change for recovering military personnel. In this specific context, the concurrence of the self-determination theory concepts that underpin the course delivery and participant outcomes is a powerful endorsement of implementation fidelity.
Effectiveness of decision aids on cancer-screening decision-making: an umbrella review protocol
Authors: Hibino Masaya , Hamashima Chisato , Iwata Mitsunaga , Terasawa Teruhiko 
Published: December 2021

IntroductionAlthough systematic reviews have shown how decision aids about cancer-related clinical decisions improve selection of key options and shared decision-making, whether or not particular decision aids, defined by their specific presentation formats, delivery methods and other attributes, can perform better than others in the context of cancer-screening decisions is uncertain. Therefore, we planned an overview to address this issue by using standard umbrella review methods to repurpose existing systematic reviews and their component comparative studies.Methods and analysisWe will search PubMed, Embase, the Cochrane Database of Systematic Reviews and the Database of Abstracts of Reviews of Effects from inception through 31 December 2021 with no language restriction and perform full-text evaluation of potentially relevant articles. We will include systematic reviews of randomised controlled trials or non-randomised studies of interventions that assessed a decision aid about cancer-screening decisions and compared it with an alternative tool or conventional management in healthy average-risk adults. Two reviewers will extract data and rate the study validity according to standard quality assessment measures. Our primary outcome will be intended and actual choice and adherence to selected options. The secondary outcomes will include attributes of the option-selection process, achieving shared decision-making and preference-linked psychosocial outcomes. We will qualitatively assess study, patient and intervention characteristics and outcomes. We will also take special care to investigate the presentation format, delivery methods and quality of the included decision aids and assess the degree to which the decision aid was delivered and used as intended. If appropriate, we will perform random-effects model meta-analyses to quantitatively synthesise the results.Ethics and disseminationEthics approval is not applicable as this is a secondary analysis of publicly available data. The review results will be submitted for publication in a peer-reviewed journal.Prospero registration numberCRD42021235957.