bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of QbD Principles for Simultaneous Quantitative Expression of Olmesartan Medoxomil, Telmisartan and Hydrochlorothiazide by RP-HPLC
Authors: Mehta Binny , Joshi Hirak , Shah Ujash , Patel Pinak 
Published: August 2021

Aim and Study Design: Aims: The current research paper describes the RP-HPLC Method for estimation of Olmesartan Medoxomil, Telmisartan, and Hydrochlorothiazide and implements the role of QbD for Data Analysis
Study design: Mentioned study is simple, rapid, economical, accurate, and robust RP-HPLC Method for Olmesartan Medoxomil, Telmisartan, and Hydrochlorothiazide and implementing QbD Approach for Data Analysis.
Place and Duration of Study: The present study was carried out at Smt. S. M. Shah Pharmacy College, Mahemdabad, Gujarat, India from October 2019 to February 2020.
Methodology: The separation was done on Hypersil ODS C18 column with dimensions (250mm x 4.6ID, Particle size: 5 microns) and Methanol: 0.02M potassium dihydrogen phosphate buffer (60:40%v/v) pH 3 used as mobile phase. The flow rate was 1.2ml/min; detection at 254nm. QbD approach was applied for data analysis. The method was validated according to ICH guidelines.
Results: The RP-HPLC method was developed and validated for Linearity and Range through the QbD approach. Factorial Design was developed through Design Expert Software for estimation of Telmisartan, Olmesartan Medoxomil, and Hydrochlorothiazide. 27 experiments were constructed and its effect was seen on Resolution, Tailing factor, and Retention Time.
Conclusion: It was clear that the proposed method was suitable for the QbD approach and identification and validation approaches. This process helps in the proper understanding of the parameters and less amount of time for the development cycle of the analytical method.
Response to Comment on “Self‐Organized Superlattice and Phase Coexistence inside Thin Film Organometal Halide Perovskite”
Authors: Kim Tae Woong , Uchida Satoshi 
Published: August 2021

AbstractIn response to the Comment on article “Self‐Organized Superlattice and Phase Coexistence inside Thin Film Organometal Halide Perovskite”, it is suggested that the facts that the existence of hexagonal PbI2 is discrepant in 3D crystallographic interpretation and that observation of () and (100) reflections occurs in general, together make the challenges that were raised in the published Comment less convincing. In addition, a new transmission electron microscopy method using direction‐selective electron beam damage of the organometal halide perovskite is disclosed.
Self‐Induced Type‐I Band Alignment at Surface Grain Boundaries for Highly Efficient and Stable Perovskite Solar Cells
Authors: Luo Chao , Zhao Yao , Wang Xianjin , Gao Feng , Zhao Qing 
Published: August 2021

AbstractThe open‐circuit voltage (VOC) of perovskite solar cells (PSCs) is reported to be significantly weakened by carrier loss at the film surface. Here, the moisture condensation at only the upper surface of perovskite films is controlled by constructing an ultralow surface temperature. Then, type‐I band alignment can be formed at the surface grain boundaries due to the etching effect of trace amounts of condensed moisture. The beneficially constructed surface type‐I band alignment can effectively repel carriers and return them to the inside of the grain, significantly avoiding the carrier loss at films surface. As a result, a superior carrier lifetime exceeding 2.5 µs is obtained and the VOC of PSC is remarkably boosted from 1.07 to 1.17 V. The minimum VOC deficit of only 0.39 V enables a substantial gain in power conversion efficiency (PCE) from 20.2% to 22.4% in one‐step spin‐coating methods. Moreover, this innovation is versatile and a champion PCE of 23.2% is also achieved in two‐step spin‐coating methods.
Electric Field‐Induced Area Scalability toward the Multilevel Resistive Switching
Authors: Singh Ranveer , Kumar Mohit , Iqbal Shahid , Kang Hyunwoo , Kim Unjeong , Park Ji‐Yong , Seo Hyungtak 
Published: August 2021

AbstractNonvolatile memory devices based on resistive switching with fast switching speed and high density have driven extensive research that is potentially ideal for data‐centric applications such as neuromorphic computing. However, due to uncontrolled filament formation, resistive random access memories (RRAM) still suffer from instability and reproducibility. In this study, NiO layer is added to the WO3‐based RRAM layer to confine the conducting path for multilevel resistive switching. The current‐voltage characteristics show the multilevel resistive switching, which is further confirmed by conductive atomic force microscopy measurements at nanoscale. At low voltages, few localized conducting channels are formed (in small area) within the oxide film while at the higher voltages they are distributed throughout the film and the active surface area increases from 4.5 to 75%. Kelvin probe force microscopy was employed to confirm nanoscale variations in surface potential, which are responsible for spatial current variation. Furthermore, it is found that the charge trapping/detrapping is the main governing mechanism and the conducting paths are formed gradually with increasing applied bias. We propose a strategy to achieve stable and reproducible electric field‐induced multilevel memory storage which will be utilized for the development of ultrahigh density multilevel nonvolatile storage and neuromorphic computing.
Fiber‐Integrated Phase Change Metasurfaces with Switchable Group Delay Dispersion
Authors: Martins Tiago , Cui Yihao , Gholipour Behrad , Ou Jun‐Yu , Frazão Orlando , MacDonald Kevin F. 
Published: August 2021

AbstractDemonstration of a fiber‐integrated non‐volatile reconfigurable metasurface providing high‐contrast group delay dispersion switching functionality is reported, which may be engineered to operate at wavelengths across the near‐infrared (telecoms) band. Light‐induced amorphous‐crystalline phase switching in a chalcogenide (germanium antimony telluride) metasurface, only a fraction of a wavelength thick, fabricated on the end‐facet of a single‐mode optical fiber, enables intensity and phase modulation of the guided wave at metasurface designated bands. Such devices present a range of opportunities in fiberized remotely programmable phase/intensity multiplexing and dynamic dispersion compensation for emerging telecommunications and data storage/processing applications, including in photonic neural network and neuromorphic computing architectures.
Four decades of continuously applied tillage or no‐tillage on soil properties and soil morphology
Authors: Mestelan Silvia , Smeck Neil , Sprunger Christine , Dyck Ashly , Dick Warren 
Published: August 2021

AbstractAs increasing amounts of cropland are managed using no‐tillage (NT), information is needed to assess long‐term impacts of this practice on soil profile properties. A well‐drained Wooster fine‐loamy (mixed, active, mesic, Oxyaquic Fragiudalf) soil and a poorly drained, Hoytville silty clay loam (fine, illitic, mesic Mollic Epiaqualf) were sampled. For comparison, adjacent undisturbed forested and grassed areas were sampled. Bulk samples were characterized using physicochemical, mineralogical, and micromorphological methods. At both sites stronger structure and more bioturbation was evident in the topsoil of NT than in PT leading to lower bulk density values and increased, highly connective macroporosity. Evidence for the formation of incipient E horizons was noted in the lower A horizons of soil in the NT plots. The cation exchange capacity (CEC) was increased at both sites with NT and is associated with the increase in soil organic C. The C/N ratio of the NT pedon was closer to that of the A horizon of the forest pedon than to that of the PT pedon. Comparisons of C levels with those estimated in the same soils prior to establishment of the grassed areas or tillage plots suggest that at the Wooster site the grass, NT, and PT pedons all sequestered C. Only the grass pedon sequestered C at the Hoytville site. For both sites, and especially for the well‐drained Wooster silt loam soil, continuous, long‐term NT management can sustain or even enhance soil functions as compared with long‐term PT management.
Herbicide tolerance in 11 grass species for minimal‐to‐no‐mow golf course rough
Authors: Patton Aaron J. , Braun Ross C. , Bearss Ryan C. , Schortgen Geoffrey P. 
Published: August 2021

AbstractResearch was conducted to determine the tolerance of 11 grass species used in minimal‐to‐no‐mow turf areas to three postemergence herbicides applied at one‐ and twofold the maximum label rates in 2018 and 2019. Grasses were transplanted into field plots in West Lafayette, IN, in 2018 and 2019, allowed time to establish (∼1−2 mo), and then either treated with one application of quinclorac, sethoxydim, and topramezone at two rates or not treated. All 11 grass species had acceptable tolerance (≤20% injury) to quinclorac applied at 0.845 kg acid equivalent (a.e.) ha–1. Quinclorac at 1.69 kg a.e. ha–1 produced moderate injury (≥21% injury) on only little bluestem [Schizachyrium scoparium (Michx.) Nash.], prairie dropseed [Sporobolus heterolepis (A. Gray) A. Gray], and switchgrass (Panicum virgatum L.). Strong creeping red fescue (Festuca rubra L. ssp. rubra Gaudin), which had ≤5% injury from all three herbicides, exhibited the greatest tolerance among grass species tested. With the exception of strong creeping red fescue, sethoxydim significantly injured all other grass species. Injury from topramezone varied among grass species and herbicide rates. Grasses tolerant (≤20% injury) to topramezone at both rates were big bluestem (Andropogon gerardii Vitman), broomsedge bluestem (Andropogon virginicus L.), indiangrass [Sorghastrum nutants (L.) Nash], strong creeping red fescue, and tall fescue [Festuca arundinacea Schreb.; syn. Schedonorus arundinaceus (Schreb.) Dumort., nom. cons.]. Tolerance among species was variable to quinclorac, sethoxydim, and topramezone, and thus turf managers should first identify desired grass species prior to herbicide application.
A systematic modeling methodology of deep neural network‐based structure‐property relationship for rapid and reliable prediction on flashpoints
Authors: Wen Huaqiang , Su Yang , Wang Zihao , Jin Saimeng , Ren Jingzheng , Shen Weifeng , Eden Mario 
Published: August 2021

AbstractDeep neural networks (DNNs) based quantitative structure–property relationship (QSPR) studies are receiving increasing attention due to their excellent performances. A systematic methodology coupling multiple machine learning technologies is proposed to systematically solve vital problems including applicability domain and prediction uncertainty in DNN‐based QSPR modeling. Key features are rapidly extracted from plentiful but chaotic descriptors by principal component analysis (PCA) and kernel PCA. Then, a detailed applicability domain (AD) is defined by K‐means algorithm to avoid unreliable predictions and discover its potential impact on prediction uncertainty. Moreover, prediction uncertainty is analyzed with dropout‐embedded DNN by thousands of independent tests to assess the reliability of predictions. The prediction of flashpoint temperature is employed as a case study, demonstrating that the model accuracy is remarkably improved comparing with the referenced model. Furthermore, the proposed methodology breaks through difficulties in analyzing the uncertainty of DNN‐based QSPRs and presents an AD correlated with the uncertainty.
The serum metabolome mediates the concert of diet, exercise, and neurogenesis, determining the risk for cognitive decline and dementia
Authors: Du Preez Andrea , Lefèvre‐Arbogast Sophie , Houghton Vikki , de Lucia Chiara , Low Dorrain Y. , Helmer Catherine , Féart Catherine , Delcourt Cécile , Proust‐Lima Cécile , Pallàs Mercè , Ruigrok Silvie R. , Altendorfer Barbara , González‐Domínguez Raúl , Sánchez‐Pla Alex , Urpi‐Sardà Mireia , Andres‐Lacueva Cristina , Aigner Ludwig , Lucassen Paul J. , Korosi Aniko , Manach Claudine , Samieri Cécilia , Thuret Sandrine 
Published: August 2021

AbstractIntroductionDiet and exercise influence the risk of cognitive decline (CD) and dementia through the food metabolome and exercise‐triggered endogenous factors, which use the blood as a vehicle to communicate with the brain. These factors might act in concert with hippocampal neurogenesis (HN) to shape CD and dementia.MethodsUsing an in vitro neurogenesis assay, we examined the effects of serum samples from a longitudinal cohort (n = 418) on proxy HN readouts and their association with future CD and dementia across a 12‐year period.ResultsAltered apoptosis and reduced hippocampal progenitor cell integrity were associated with exercise and diet and predicted subsequent CD and dementia. The effects of exercise and diet on CD specifically were mediated by apoptosis.DiscussionDiet and exercise might influence neurogenesis long before the onset of CD and dementia. Alterations in HN could signify the start of the pathological process and potentially represent biomarkers for CD and dementia.
Preventing and improving interactions between autistic individuals and the criminal justice system: A roadmap for research
Authors: Shea Lindsay Lawer , Cooper Dylan , Wilson Amy Blank 
Published: August 2021

AbstractResearchers have identified that autistic individuals are encountering the criminal justice system as victims, offenders, and witnesses at high rates. The prevalence of autism spectrum disorder (ASD) is increasing and generating a comprehensive approach to addressing criminal justice system involvement among autistic individuals is a timely and urgent need. Revisions to an established framework generated for use among individuals with mental health diagnoses, the sequential Intercept Model (SIM), were produced by an international consortium of interdisciplinary stakeholders presenting a new opportunity to identify gaps in ASD research and generate preventive solutions across the criminal justice system. The revised SIM maps each criminal justice system component, or Intercept, and includes paths for the experiences of autistic individuals as victims or witnesses to crimes as well as offenders to catalyze new and interdisciplinary research, policy, and practice efforts. As the field of ASD research continues to grow, the revised SIM is a promising pathway to avoiding siloed research approaches, including diverse autistic voices, and contributing to international dialogue about criminal justice reform at a critical juncture.Lay SummaryAutistic individuals are encountering the criminal justice system as victims, offenders, and witnesses at high rates. A revised version of the SIM generated by an international consortium provides a cohesive framework to ensure research focused on this topic extends across the criminal justice system. Preventing and improving interactions between autistic individuals and the criminal justice system is an urgent research, policy, and practice need.
The sustainability prism of structural changes in the European Union agricultural system: The nexus between production, employment and energy emissions
Authors: Jurkėnaitė Nelė , Baležentis Tomas , Štreimikienė Dalia 
Published: August 2021

AbstractOver the recent decades, the evolution of the European Union (EU) agricultural system has resulted in significant structural changes in member states. Knowledge about the nature and main patterns of structural change is critical to select a sustainable development path for the EU agriculture. This paper contributes to the academic discourse on structural changes in agriculture demonstrating the nexus between socio‐economic and environmental aspects of development. In this regard, results are important to understand the contribution of the EU agriculture to climate change, because study deals with energy use and greenhouse gas emissions. The research covers period from 2008 to 2018 and investigates the fundamental structural change measures, namely, gross value added, labour and agriculture‐related energy emissions, in EU member states. Structural changes are investigated applying a shift‐share analysis that allows calculating a performance of individual member states, compared to the EU economy. The applied shift‐share model investigates the situation of individual member states employing three components. The first component tracks the development of the selected measures with the EU economy growth, the second component shows the change due to effect of economic activities and the third shows competitiveness of agriculture in member states. The shift‐share analysis empowers ranking member states in accordance with their progress towards the sustainable development. Findings suggest that EU economy faces the outflow of labour from agriculture and this trend is common for most countries. The changes of gross value added and emissions for fuel combustion demonstrate both upward and downward trends. However, research results suggest that new member states often face more fundamental changes.
Key sunitinib‐related biomarkers for renal cell carcinoma
Authors: Peng Yun , Dong Shiqiang , Song Yuxuan , Hou Dingkun , Wang Lili , Li Bowen , Wang Haitao 
Published: August 2021

AbstractBackgroundRenal cell carcinoma (RCC) contributed to 403,262 new cases worldwide in 2018, which constitutes 2.2% of global cancer, nevertheless, sunitinib, one of the major targeted therapeutic agent for RCC, often developed invalid due to resistance. Emerging evidences suggested sunitinib can impact tumor environment which has been proven to be a vital factor for tumor progression.MethodsIn the present study, we used ssGSEA to extract the immune infiltrating abundance of clear cell RCC (ccRCC) and normal control samples from GSE65615, TCGA, and GTEx; key immune cells were determined by Student's t‐test and univariable Cox analysis. Co‐expression network combined with differentially expressed analysis was then applied to derive key immune‐related genes for ccRCC, followed by the identification of hub genes using differential expression analysis. Subsequently, explorations and validations of the biological function and the immune‐related and sunitinib‐related characteristics were conducted in KEGG, TISIDB, Oncomine, ICGC, and GEO databases.ResultsWe refined immature dendritic cells and central memory CD4 T cells which showed associations with sunitinib and ccRCC. Following, five hub genes (CRYBB1, RIMBP3C, CEACAM4, HAMP, and LYL1) were identified for their strong relationships with sunitinib and immune infiltration in ccRCC. Further validations in external data refined CRYBB1, CEACAM4, and HAMP which play a vital role in sunitinib resistance, immune infiltrations in ccRCC, and the development and progression of ccRCC. In conclusion, our findings could shed light on the resistance of sunitinib in ccRCC and provide novel biomarkers or drug targets for ccRCC.
Patient participation in multidisciplinary tumor conferences: How is it implemented? What is the patients’ role? What are patients’ experiences?
Authors: Ansmann Lena , Heuser Christian , Diekmann Annika , Schellenberger Barbara , Biehl Claudia , Danaei Mahmoud , Eichler Christian , Heinz Dina , Hocke Andrea , Malter Wolfram , Melekian Badrig , Metin Havva , Mustea Alexander , Palatty Jenci , Peisker Uwe , Petschat Ines , Ernstmann Nicole 
Published: August 2021

AbstractBackgroundPrior research has shown that around 5%–7% of patients in breast cancer centers in Germany participate in the discussion of their own case within a multidisciplinary tumor conference (MTC). The PINTU study is one of the first to research this practice. The objective is to describe (a) how patient participation in MTCs is implemented, (b) what is the role of patients, and (c) how patients experience MTCs.MethodsMTCs in six breast and gynecological cancer centers in North Rhine‐Westphalia, Germany, with and without patient participation, are studied prospectively by (non)participatory, structured observation. Breast and gynecological cancer patients completed surveys before, directly after, and 4 weeks after MTC participation. Data are analyzed descriptively.ResultsCase discussions of a sample of n = 317 patients (n = 95 with MTC participation and n = 222 without) were observed. Survey data were obtained from n = 242 patients (n = 87 and n = 155). Observational data showed heterogeneity in the ways MTC participation was practiced. Among participating patients, 89% had the opportunity to express their opinion and 61% were involved in decision‐making. Whereas most patients reported positive experiences and would recommend participation, some had negative experiences and regretted participating.ConclusionsDue to a lack of recommendations, hospitals implement patient participation in MTCs in many different ways. So far, it is unknown which setting and procedures of MTC participation are beneficial for patients. However, existing evidence on communication in cancer care together with this exploratory study's findings can build the basis for developing recommendations for hospitals that invite their patients to MTCs.Clinical trial registration numberGerman Clinical Trials Register Nr. DRKS00012552.
Chemical Constituents and Anti‐Gastric Ulcer Activity of Essential Oils of Alpinia officinarum (Zingiberaceae), Cyperus rotundus (Cyperaceae), and Their Herbal Pair
Authors: Qu Hui‐Juan , Lin Kai‐Wen , Li Xiao‐Liang , Ou Hong‐Ya , Tan Yin‐Feng , Wang Mei , Wei Na 
Published: August 2021

AbstractThe essential oil (EO) of the herbal pair (HP), Alpinia officinarum‐Cyperus rotundus (HP G‐X) has been conventionally used in traditional Chinese medicine (TCM) for ‘warming the stomach’ and relieving pain. However, its pharmacologically active compounds, as well as the mechanism of its anti‐gastric ulcer properties remain unclear. In this study, the EOs obtained from HP G‐X and its corresponding single herbs were analyzed using GC/MS. A total of 74, 56, and 85 compounds were detected in A. officinarum (GLJ), C. rotundus (XF), and HP G‐X, accounting for 93.2 %, 89.5 %, and 92.0 % of the total content, respectively. GLJ mainly contains 1,8‐cineol (22.0 %) and α‐terpineol (11.8 %), whereas cyperenone (22.4 %) and cyperene (12.3 %) were the major constituents in XF. These four compounds were also detected in the HP G‐X with relatively high composition as 11.8 %, 5.5 %, 11.8 %, and 10.6 %, respectively. Although no new compounds were detected in HP G‐X, the relative concentration of some compounds increased, while others decreased or even disappeared. HP G‐X showed the lowest toxicity (TC50 >800 μg/mL) against human gastric mucosal epithelial cells (GES‐1) and had the best protective effect against ethanol‐induced GES‐1 cell damage compared to the individual herbs. In vitro studies demonstrated that HP G‐X and the corresponding single herbs significantly reduced IL‐6, TNF‐α, and COX‐2. In addition, in vivo investigations indicated that HP G‐X can protect the gastric mucosa of mice from ethanol‐induced damage by inhibiting the inflammatory reaction and providing analgesia. It can also inhibit the expression of NF‐κBp65, COX‐2, and TRPV1 protein, reduce the concentrations of IL‐6 and TNF‐α, and relieve heat‐induced pain. This study further substantiated the traditional application of HP G‐X against gastric ulcers through both in vivo and in vitro investigations.