bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nation Building Through Translation: Kleist's “Earthquake” in Meiji Japan
Authors: Teupert Jonas 
Published: February 2025

AbstractIn this essay, I consider Mori Ogai's translation of Heinrich von Kleist's “Das Erdbeben in Chili” as a contribution to the linguistic reform debates in Meiji Japan, which centered on the unification of the spoken and written language. I analyze the syntax of Ogai's translation and argue that his stylistic reduction of the original transforms Kleist's text into reading material for popular education in the new Japanese nation state. Drawing on Yoko Tawada, I then illuminate the constitutive foreignness of Kleist's language, which resists national appropriations. Nuancing Tawada's claims, I show that Ogai's Kleist translation negotiates the tensions between various languages, an instance of what Lydia Liu calls “translingual practice,” and thus participates in the ongoing transformation of Japanese during the Meiji era. Ultimately, I contribute a new understanding of nation building through translation, emphasizing that this process embeds the nation in a transnational and translingual network.
Enhancing Learning Transfer From Continuing Education to the Workplace Through an Actor‐Oriented Approach: A Design‐Based Research Study
Authors: Hirv‐Biene Jaanika , Tammets Kairit , Ley Tobias , Wagner Marlene 
Published: February 2025

ABSTRACTIn academic continuing education, the transfer of learning from an academic setting to the workplace is critical. Current research on transfer of training has focused less on the situative determinants for such transfer, and how these are construed by the learner. We assume an actor‐oriented perspective on transfer for investigating the individual pathways of what and how professional learners transfer between contexts. Using the lens of self‐directed learning, the paper sheds light on the support useful in this process. We conducted a design‐based research project, in which we created and implemented a learning design for a continuing education course with a specific focus on learning transfer. We then interviewed a cohort of students on their transfer experience 8 months after the course to understand what the students were transferring, evaluate the support provided during the course and detect opportunities for further support. Results indicated that it was important to establish structures that bridge the academic and work contexts, and prompt reflection and interaction. We discuss the opportunities for further support, especially improving possibilities for personalised feedback.
Combining Percentage Prostate‐Specific Antigen Reduction and Multiparametric Magnetic Resonance Imaging to Reduce Unnecessary Biopsy After Focal Therapy With High‐Intensity Focused Ultrasound for Prostate Cancer
Authors: Hsieh Po‐Fan , Naruse Jun , Yuzuriha Soichiro , Umemoto Tatsuya , Huang Chi‐Ping , Shoji Sunao 
Published: February 2025

ABSTRACTObjectivesTo test the feasibility of combining percentage prostate‐specific antigen (PSA) reduction and multiparametric magnetic resonance imaging (mpMRI) to determine the clinical scenario in which follow‐up biopsy could be avoided after focal therapy (FT) with high‐intensity focused ultrasound (HIFU) for prostate cancer.MethodsWe reviewed 90 men treated with FT. Percentage PSA reduction was calculated by PSA nadir within postoperative 6 months. mpMRI was arranged at postoperative 6 months, followed by routine biopsy. Logistic regression analyses were performed to identify predictors for clinically significant prostate cancer (csPC) on follow‐up biopsy. Receiver operating characteristic curve analysis was done to assess the area under the curve (AUC). The diagnostic performance of percentage PSA reduction and mpMRI to predict csPC was also calculated.ResultsEight patients had csPC recurrence. Percentage PSA reduction and Prostate Imaging–Reporting and Data System (PI‐RADS) ≥ 3 at postoperative 6 months were predictors for csPC (p = 0.033 and p = 0.02, respectively). The AUC of mpMRI, percentage PSA reduction, and their combination were 0.95, 0.816, and 0.982, respectively. The sensitivity, specificity, positive predictive value, and negative predictive value of PSA reduction < 70% and PI‐RADS ≥ 3 to predict csPC were 87.5%, 69.5%, 21.9%, 98.3%, and 87.5%, 96.3%, 70%, 98.8%, respectively. Using the criteria of PSA reduction < 70% or PI‐RADS ≥ 3 to determine biopsy candidates could avoid 60% of biopsies, without missing csPC.ConclusionFor patients whose PSA reduction > 70% and PI‐RADS < 3, we suggested avoiding routine biopsy at 6 months after FT with HIFU.
Real‐world outcomes after endovascular thrombectomy in patients with large infarct cores
Authors: Wellington Daniel James , Donnelly Joseph , Hong Jae Beom , Diprose William K. , Barber P. Alan 
Published: February 2025

AbstractPatients with large infarct cores on imaging at hospital presentation who are then treated with endovascular thrombectomy achieved functional independence rates ranging from 14%–30% in randomised controlled trials. We describe our ‘real‐world’ experience with these patients. About one‐third were independent at day 90, similar to trial results. This was associated with higher rates of complications and double the length of stay.
Care Tasks and Caregiver Burden Among Family Caregivers of Patients With Mental Disorders in China: Illness Perception as a Mediator and Social Support as a Moderator
Authors: Huang Zhuoer , Yi Qifeng , Yao Hao , Li Kunmei , Li Chuan , Shi Yimeng , Hu Shuang , Chen Jianhua , Xu Yifeng 
Published: February 2025

ABSTRACTIntroductionCaring for a family member with mental disorders is burdensome, which may not only damage the caregivers' well‐being and health, but also hinder patients' recovery. It is critical to investigate the underlying mechanisms for caregiver burden.AimTo examine the mediating effect of illness perception and the moderating function of social support on the association between care tasks and caregiver burden.MethodA total of 1169 family caregivers of patients with mental disorders were recruited via convenience sampling across China. Data were collected using acceptable reliability scales (Cronbach's α > 0.6). The relationships among care tasks, illness perception, social support and caregiver burden were examined in the SPSS PROCESS macro.ResultsIllness perception partially mediates the relationship between care tasks and overall caregiver burden, personal strain and role strain, while social support only alleviates the impact of care tasks on personal strain but not on role strain.DiscussionCare tasks could positively predict caregiver burden. As a mediating moderating mechanism, illness perception and social support could further explain how care tasks affect caregiver burden.Implications for PracticePsychiatric nurses should provide psychoeducation for family caregivers of patients with mental illness to improve their negative illness perception, as well as increase their social support.
Genomic Vulnerability of a Sentinel Mammal Under Climate Change
Authors: Schmidt Danielle A. , Russello Michael A. 
Published: February 2025

ABSTRACTClimate change poses a significant threat to biodiversity, particularly in alpine ecosystems where species have already undergone elevational range shifts. Genomics can be used to estimate the adaptive potential of species, as well as the shift in adaptive genomic composition necessary for populations to adjust to climate change (e.g., genomic offset). Here, we investigated patterns of climate‐mediated adaptive genetic variation and predicted the degree of genomic offset under multiple climate change scenarios for a sentinel alpine mammal, the American pika (Ochotona princeps). We collected genome‐wide data (29,709 SNPs) from 363 individuals spanning the entire range in western North America and employed genotype‐environment association analyses to identify 924 robust outlier SNPs, several of which were linked to genes previously associated with high elevation and hypoxia responses in various pika species (Ochotonidae). Adaptive genomic variation was most strongly influenced by mean warmest month temperature, followed by precipitation of the coldest quarter. Spatial patterns of genomic offset were heterogeneous, significantly predicted by levels of adaptive genetic variation, elevation and latitude. Sites within the Northern Rocky Mountains exhibited the highest genomic offset under projected climate change despite possessing high levels of adaptive genetic variation. As such, while our study provides an example of how genomic data can be used to explore the potential consequences of climate change, it further highlights the need for careful consideration of genomic offset values within their proper ecological context.
Selection Over Small and Large Spatial Scales in the Face of High Gene Flow
Authors: Rumberger C. , Armstrong M. , Kim M. , Ponce R. , Melendez J. , DeBiasse M. , Caplins S. , Bay R. 
Published: February 2025

ABSTRACTLocal adaptation represents the balance of selection and gene flow. Increasingly, studies find that adaptation can occur on spatial scales much smaller than the scale of dispersal, resulting in balanced polymorphisms within populations. However, microgeographic adaptation might be facilitated or hindered by large‐scale environmental heterogeneity, such as across latitude. Marine systems present a special case, as many marine species have high dispersal capacity so that dispersal ‘neighbourhoods’ may encompass environmental heterogeneity over both small and large spatial scales. Here, we leverage fine‐scale sampling across the California range of the Pacific purple sea urchin (Strongylocentrotus purpuratus), a species with previous evidence of both local adaptation and extremely high gene flow. We find that despite the complete absence of neutral population structure, satellite‐based sea surface temperature and tidal zone are associated with subtle genetic differences among populations, suggesting that balanced polymorphisms can lead to adaptation across both large (latitudinal) and small (subtidal vs. intertidal) scales. In fact, some of the same genetic variants differentiate populations at both spatial scales, potentially because both environmental parameters are related to temperature. Further, we find that genes that are expressed at a single tissue or life history stage are more divergent than expected across both latitudinal and tidal zone comparisons, suggesting that these genes have specific functions that might generate phenotypic variation important for local adaptation. Together, these results suggest that even in species with little population structure, genetic variation can be sorted across varying spatial scales, potentially resulting in local adaptation across complex environmental mosaics.
GhMYB102 affects cotton fibre elongation and secondary wall thickening by regulating GhIRX10 in cotton
Authors: Wu Aimin , Shen Tong , Lu Jianhua , Fu Xiaokang , Yang Miaoqian , Sun Mengxi , Ma Liang , Lian Boying , Wu Hongmei , Li Yiran , Yu Shuxun , Wei Hengling , Wang Hantao 
Published: February 2025

SummaryUpland cotton (Gossypium hirsutum) is a principal economic crop and a fundamental raw material for the textile industry. The quality of cotton fibres is significantly influenced by the synthesis of cell wall polysaccharides. This study focuses on GhIRX10, a beta‐1,4‐xylosyltransferase crucial for xylan backbone synthesis. Overexpression of GhIRX10 enhances xylan synthesis, which impacts fibre elongation and secondary cell wall thickening. GhMYB102, identified as a direct regulator of GhIRX10 expression, was confirmed through comprehensive validation. Overexpression of GhMYB102 resulted in a similar phenotype as OE‐GhIRX10: increased cell wall thickness and reduced fibre length. Overexpression of GhMYB102 upregulated the expression of key cell wall synthesis‐related genes, including GhCESA4/7/8, GhIRXs, GhCESAs, GhGUXs, GhTBLs, GhXTHs, and GhXXTs. Consequently, the cellulose and hemicellulose contents in OE‐GhMYB102 lines were significantly increased. GhMYB102 was also validated as a target gene regulated by GhFSN1 and GhMYB7, with the ability to reciprocally regulate GhFSN1 expression. In summary, we propose a regulatory model where GhMYB102 promotes the expression of GhIRX10 and other cell wall‐related genes, thereby affecting fibre quality. This study elucidates the regulatory network of secondary cell wall synthesis in cotton and provides potential targets for improving fibre quality through molecular breeding.
Microbiota does not influence tumor development in two models of heritable cancer
Authors: Spring Jessica , Gurbuxani Sandeep , Golovkina Tatyana 
Published: February 2025

ABSTRACT

Microbial impact on tumorigenesis of heritable cancers proximal to the gut is well-documented. Whether the microbiota influences cancers arising from inborn mutations at sites distal to the gut is undetermined. Using two models of heritable cancer,
Trp53
-deficient mice and Wnt1-transgenic mice, and a gnotobiotic approach, we found the microbiota to be inconsequential for tumor development. This work furthers our understanding of the degree of the microbial impact on tumor development.

IMPORTANCE

The influence of the microbiome on the development of cancer is well-documented with many if not all published studies reporting either a positive or a negative impact. None of the published studies, however, presented data on the influence of the microbiome on the development of heritable cancer. We find that the microbiota has no influence on cancer development in two models of spontaneous cancers driven by germline
Trp53
deficiency and constitutive Wnt1 signaling.
Validation of rectal swabbing for total and aerobic gut microbiota study
Authors: Marin Julie , Bertoye Paul Albin , Birgy Andre , Dziri Samira , Lescat Mathilde 
Published: February 2025

ABSTRACT

In microbiota research, whole stool sampling is the conventional approach but can be problematic or infeasible for certain patients. This study aims to validate the use of rectal swabbing as an alternative method for microbiota analysis and determine optimal storage conditions suitable for various clinical settings, including intensive care units. We evaluated different sampling techniques and storage temperatures. Our findings indicated that rectal swabs yield microbiota diversity comparable to whole stool samples. Notably, storage conditions significantly impacted microbiota profiles, with increased
E. coli
and
Enterococcus sp
. quantifications observed at room temperature (RT). Consequently, we recommend immediate refrigeration of rectal swabs to reliably assess aerobic and total microbiota, particularly for patients requiring urgent care, such as antibiotic treatment.

IMPORTANCE
We developed a pragmatic approach to study total and aerobic gut microbiota, applicable in numerous clinical units, such as intensive care or emergency units, where whole stool sampling is often impractical. This approach employs ESwab devices, which are already commonly used in hospitals.
Barrow entropies in black hole thermodynamics
Authors: Capozziello Salvatore , Shokri Mehdi 
Published: February 2025

Abstract
We study the thermodinamic features of static, spherically-symmetric Schwarzschild black holes adopting different types of Barrow entropy. Specifically, in addition to the standard Barrow entropy, we consider a logarithmic-corrected type of this entropy by taking into account some loop quantum gravity effects. Moreover, we investigate the black hole thermodynamics from the viewpoint of Barrow entropy in presence of non-extensivity effects coming from the Tsallis statistics. Finally, we compare the results obtained for different Barrow-based entropies.
Revisiting VerilogEval: A Year of Improvements in Large-Language Models for Hardware Code Generation
Authors: Pinckney Nathaniel , Batten Christopher , Liu Mingjie , Ren Haoxing , Khailany Brucek 
Published: February 2025

The application of large-language models (LLMs) to digital hardware code generation is an emerging field, with most LLMs primarily trained on natural language and software code. Hardware code like Verilog constitutes a small portion of training data, and few hardware benchmarks exist. The open-source VerilogEval benchmark, released in November 2023, provided a consistent evaluation framework for LLMs on code completion tasks. Since then, both commercial and open models have seen significant development.
In this work, we evaluate new commercial and open models since VerilogEval’s original release—including GPT-4o, GPT-4 Turbo, Llama3.1 (8B/70B/405B), Llama3 70B, Mistral Large, DeepSeek Coder (33B and 6.7B), CodeGemma 7B, and RTL-Coder—against an improved VerilogEval benchmark suite. We find measurable improvements in state-of-the-art models: GPT-4o achieves a 63% pass rate on specification-to-RTL tasks. The recently released and open Llama3.1 405B achieves a 58% pass rate, almost matching GPT-4o, while the smaller domain-specific RTL-Coder 6.7B models achieve an impressive 34% pass rate.
Additionally, we enhance VerilogEval’s infrastructure by automatically classifying failures, introducing in-context learning support, and extending the tasks to specification-to-RTL translation. We find that prompt engineering remains crucial for achieving good pass rates and varies widely with model and task. A benchmark infrastructure that allows for prompt engineering and failure analysis is essential for continued model development and deployment.
Targeting PRC2 Enhances the Cytotoxic Capacity of Anti-CD19 CAR-T Cells Against Hematological Malignancies
Authors: Carvalho Maria Leticia R. , Andrade Clara O. , Cabral-Piccin Mariela P. , Kinker Gabriela S. , Vitiello Glauco A. F. , Cambui Raylane A. G. , Abdo Luiza , Mannarino Eduardo , Elias Bruno D. S. , Araujo Emmanuel Vinicius O. , Chaves Alexandre S. , Pereira Pedro Henrique B. , Hajdu Karina , Rondinelli Amanda , Gusmao Arianne , Pierre Maria Luisa M. , Brasil-Costa Igor , Zanella Caroline P. , Lemos Marta Maria M. , Batista Marjorie V. , Filho Jayr S. , Arrowsmith Cheryl , de Lima Vladmir Cordeiro , Bonamino Martin , da Silva Medina Tiago 
Published: February 2025

Abstract
Chimeric antigen receptor (CAR) T cell therapy is increasingly being adopted as a clinical modality for patients with relapsed/refractory hematological malignancies. Despite the clinical efficacy of CAR-T cell therapy, a considerable fraction of patients still relapses during the first months following CAR-T cell infusion. The limited CAR-T cell efficiency is thought to relate to epigenetic mechanisms involved in T cell suppression and dysfunction. Here, screening of multiple epigenetic inhibitors revealed that targeting PRC2 consistently induced the development of granzyme B+ effector memory CD8+ T cells. Notably, PRC2 inhibition also promoted the long-term persistence of granzyme B+ effector memory 19BBζ CAR-T cells and sustainably enhanced their antitumor activity both in vitro and in vivo. Consistent with their long-lasting antitumor activity, PRC2-inhibited 19BBζ CAR-T cells did not exhibit signs of exhaustion over time. Furthermore, TCR restimulation along with PRC2 inhibition promoted the differentiation of patient-derived anti-CD19 CAR-T cells to a granzyme B+ effector memory phenotype with enhanced cytotoxic features that elicited potent antitumor responses. A gene signature derived from in-house PRC2-inhibited 19BBζ CAR-T cells was enriched in tisagenlecleucel (tisa-cel) BBζ CAR-T cell therapy responders with large B-cell lymphoma. Collectively, these results demonstrate that targeting PRC2 may be a promising approach to enhance a functional effector program in CAR-T cells to improve the efficacy in treating hematological malignancies.
Residential segregation and colorectal cancer screening in the United States, 2010-2018
Authors: Santiago-Rodriguez Eduardo J. , Shariff-Marco Salma , Bailey Zinzi D. , White Justin S. , Allen Isabel E. , Hiatt Robert A. 
Published: February 2025

Abstract
Background: Residential segregation limits the access to resources, primarily due to disinvestment. This study evaluated the association between residential segregation and colorectal cancer (CRC) screening in the US, and whether findings differed by race and ethnicity. Methods: Restricted National Health Interview Survey data (2010-2018) were used to ascertain CRC screening adherence per USPSTF recommendations. Residential segregation was operationalized using the Index of Concentration at the Extremes (ICE), based on income, race, and ethnicity information obtained from the 2014-2018 American Community Survey estimates for counties. Multivariable logistic regression models with robust variance estimators accounting for within-county correlation were used. Analyses were stratified by race and ethnicity, and weighted to represent the US population. Results: In this cross-sectional study (n=44,690), participants residing in less advantaged counties had lower CRC screening adherence than those residing in the most advantaged counties (Q1 vs Q5, OR [95% CI]: ICE income, 0.77 [0.70-0.86]; ICE race, 0.86 [0.77-0.96]; ICE race+income, 0.75 [0.67-0.84]. In race and ethnicity stratified analyses, we observed that overall findings were mostly driven by White people, and estimates were less precise with no clear gradients among racial and ethnic minoritized groups. Among Black participants, CRC screening did not vary across quintiles of economic segregation. Conclusions: Residential segregation was associated with CRC screening. Impact: Interventions aimed at improving CRC screening uptake in the US should address structural barriers present in areas with higher concentrations of low-income minoritized racial and ethnic groups, and how features of residential segregation might diferentially affect racial and ethnic groups.
A new, conspicuously coloured snapping shrimp from the north-western Indian Ocean (Malacostraca: Decapoda: Alpheidae: Alpheus)
Authors: Anker Arthur 
Published: February 2025

A new, brightly coloured and morphologically distinctive species of the alpheid genus Alpheus Fabricius, 1798 is described based on a single female specimen collected in shallow waters of Masirah Island, Oman. Alpheus sarapis sp. nov. appears to be morphologically somewhat intermediate between the A. leviusculus Dana, 1852, A. edwardsii (Audouin, 1826) and A. paracrinitus Miers, 1881 species groups, although the presence of slight sinuses on the major chela palm suggests that it may be a derived member of either of the former two groups.
Aplicação de terapia robótica (C-Mill) para reabilitação de paciente com lesão de sistema nervoso central
Authors: Dalbeto Fabio Augusto Moraes Dias , Siena Wilian Carlos , Simas Desiree Garcia de , Bonatelli Deiseane , Souza Daniel Gottardo de 
Published: February 2025

A tecnologia por meio da terapia robótica, atualmente, vem ocupando uma importante posição para a sociedade atual. Observa-se que esse tipo de abordagem favorece de maneira bastante significativa a complementação terapêutica frente a um processo de reabilitação. Isso justifica o aumento de investimento na área da saúde com a finalidade de criações de que contribuam para a assistência dos pacientes. Assim, o que se percebe é que recentemente a utilização das terapias robóticas na reabilitação humana vem ocupando cada vez mais espaços dentro do tratamento, pois se mostra uma influência benéfica dentro desse processo, visto que notoriamente ela dinamiza e proporciona resultados positivos nas sessões de reabilitação. Além disso, os mecanismos da robótica proporcionam a execução de determinados exercícios de modo controlado, eficaz e confiável, sendo validado na literatura como fator essencial para a melhora da habilidade motora. Isso atrelado ao lado lúdico dos equipamentos que possibilitam maior interação aos pacientes e consequentemente um maior envolvimento e diversão, o que reflete diretamente na permanência e confiança no processo de reabilitação.