bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pencegahan Catheter Associated Urinary Tractus Infection Melalui Catheter Maintenance
Authors: Waluyo Waluyo , Kusnanto Kusnanto , Kartini Yanis 
Published: August 2021

Catheter associated urinary tractus infection is a urinary tract infection due to urinary catheter placement that lasts more than two days. Catheter associated urinary tractus infection can be prevented by applying infection prevention practices based on proven evidence. Catheter maintenance are some of the measures to prevent the infection. Nurse compliance with catheter care and catheter maintenance is very important in preventing catheter associated urinary tractus infection. The aims of this study was to determine the increase in prevention of catheter associated urinary tractus infection by training catheter maintenance. This research was an experimental using a one-group pre-post test design. The study population consisted of inpatient nurses by 51 nurses and 116 patients with permanent urinary catheters. The technique of sampling used total sampling. Data analysis performed with a Wilcoxon signed rank test test. The result of wilcoxon test showed the p value of signature of 0.00 so that there was an influence between training on catheter maintenance on increasing the prevention of catheter associated urinary tractus infection. The result of training catheter maintenance was to increase nurse compliance in preventing catheter associated urinary tractus infection.
Keywords: catheter maintenance; urinary tractus infection

ABSTRAK

Catheter Associated Urinary Tractus Infection merupakan infeksi saluran kemih akibat pemasangan kateter urin yang menetap lebih dari dua hari. Catheter associated urinary tractus infection dapat dicegah dengan cara menerapkan praktik pencegahan infeksi berdasarkan bukti yang sudah teruji. Catheter maintenance merupakan sebagian dari beberapa tindakan untuk mencegah infeksi tersebut. Kepatuhan perawat terhadap pelaksanaan catheter maintenance sangat penting dalam mencegah catheter associated urinary tractus infection ini. Tujuan penelitian ini adalah untuk mengetahui peningkatan pencegahan catheter associated urinary tractus infection dengan pelatihan catheter maintenance. Penelitian ini merupakan quasi eksperiment dengan menggunakan rancangan one-group pre-post test design. Populasi penelitian ini perawat ruang rawat inap sebesar 51 perawat dan 116 pasien yang terpasang kateter urin menetap. Tehnik sampling yang digunakan adalah total sampling. Analisis data dilakukan dengan uji statistik Wilcoxon signed rank test dengan hasil p value signifikansi 0,00 sehingga ada ada pengaruh antara pelatihan tentang catheter maintenance terhadap peningkatan pencegahan catheter associated urinary tractus infection. Hasil dalam penelitian ini adalah pelatihan catheter maintenance meningkatkan kepatuhan perawat dalam pencegahan catheter associated urinary tractus infection.
Kata kunci: catheter maintenance; urinary tractus infection
Pemberian Ekstrak Rumput Kebar (Biophytum petersianum Klotzsh) Dapat Meningkatkan Berat Testis Mencit Model Diabetes Mellitus
Authors: Djurumana Yohana , I’tishom Reny , Purwanto Bambang 
Published: August 2021

Background: In addition to the influence of diabetes on male reproduction lowers testosterone levels of FSH and LH, the second number of hormones is reduced will interfere with the process of spermatogenesis. If the spermatogenesis process is interrupted then the number of germ cells decreases, this will cause a decrease in the weight of the testes. Objective: To analyze the effect of extract grass administration to the weight of the testicles diabetes Mellitus mice between the treatment group and the control. Methods: The research used DM male mice which is divided into 5 groups each consisting of 6 mice. Day 1 till day 5 all STZ-induced groups. On the 11th day to the 45th day, the control group (K +) was given metformin 2mg/head/day. The control group (K-) was given CMC-Na 1%. Group P1, P2 and P3 was given Kebar grass with dose of 67, 5mg/day, 135mg/kg/day, and 270mg/kg/day and metformin 2mg/head/day. The 46th was done with the release and sampling of the right and left testicles. Testicular weighing used analytic scales 0.001gram. Results: Statistical tests showed that there was a discrepancy in the p-value = 0.000 (0.05) on testicular weight. Conclusion: Increased testicular weight model of diabetes mellitus that gets the grass extractions of Kebar.
Keywords: Kebar grass extract; testicular weight; diabetes mellitus

ABSTRAK

Latar belakang: Pengaruh diabetes mellitus terhadap reproduksi pria menurunkan kadar testosterone yaitu FSH dan LH, jumlah ke dua hormone tersebut berkurang maka akan mengganggu roses spermatogenesis. Proses spermatogenesis terganggu maka jumlah sel germinal mengalami penurunan, hal ini akan menyababkan berat testis menurun. Tujuan: menganalisisi pengaruh pemberian ekstrak rumput kebar terhadap berat testis mencit model diabetes mellitus antara kelompok perlakuan dan kontrol. Metode: penelitian menggunakan mencit DM yang dibagi menjadi lima kelompok setiap kelompok terdiri dari 6 ekor mencit. Hari ke 1 sampai hari ke 5 semua kelompok diinduksi STZ. Hari ke 11 sampai hari ke 45 kelompok kontrol (K+) disonde metformin 2mg/ekor/hari. Kelompok kontrol (K-) disonde CMC Na 1%. Kelompok P1,P2 dan P3 disonde ekstrak rumput kebar dengan dosis, 67,5mg/kgBB/hari, 135mg/kgBB/hari, 270mg/kgBB/hari dan metformin 2mg/ekor/hari. Hari ke 46 dilakukan pembedahan dan pengambilan sampel testis kanan dan kiri dan Penimbangan berat testis mencit menggunakan timbangan analitik dengan skala 0,001 gram. Hasil: uji statistik menunjukkan terdapat perbedaan bermakna dengan nilai p= 0,000 (p<0,05) pada berat testis mencit. Kesimpulan: berat testis meningkat dibandingkan kelompok kontrol
Kata kunci: ekstrak rumput kebar; berat testis; diabetes mellitus
Gambaran Umur, dan Jenis Kelamin Pasien Kanker Payudara di RS Ibnu Sina Kota Makassar
Authors: Elmika Elma , Adi Mateus Sakundarno 
Published: August 2021

Breast cancer is the most popular neither in advanced nor developing countries within case of 38 per 100,000 women. Breast cancer is still one of the health problems that occur in women in the world but does not rule out the possibility of men. This study aims to found the description of the age, and sex of breast cancer patients at Ibnu Sina Hospital Makassar. This research method was used a cross-sectional study with secondary data from medical records in 2018-2019 diagnosed with breast cancer. The data obtained of the number of annual cases, age, sex, and the number of cases that died. The results showed that in 2019, it was twice as high as 70.8% patients with a diagnosis of breast cancer, with an average age of 45-65 years, in female-dominated sex, but in this study there were 1.1 % male, the highest number of deaths occurred in 2018 with 12 cases 60.0%. The conclusion of this research is breast cancer are generally dominated from women but does not ruled out the possibility of occurring in the men, ages 45-65 who are middle-aged or elderly. So it is expected to always have a routine check as a preventative stage.
Keywords: age; gender; breast cancer

ABSTRAK

Kanker payudara adalah kanker terbanyak di negara maju maupun negara berkembang dengan insiden 38 per 100.000 perempuan. Kanker payudara masih menjadi salah satu masalah kesehatan yang terjadi pada perempuan di dunia, namun tidak menutup kemungkinan terjadi pada laki-laki. Penelitian ini bertujuan mengetahui gambaran umur, dan jenis kelamin pasien kanker payudara di RS Ibnu Sina Makassar. Metode penelitian ini menggunakan cross-sectional dengan data sekunder rekam medis tahun 2018-2019 yang terdiagnosis kanker payudara. Data yang diperoleh yaitu jumlah kasus per tahun, umur, jenis kelamin, dan jumlah kasus meninggal. Hasil penelitian menunjukkan pada tahun 2019 dua kali lipat lebih tinggi dengan 70,8% pasien dengan terdiagnosis kanker payudara, dengan rata-rata usia 45-65 tahun, pada jenis kelamin didominasi oleh perempuan namun pada penelitian ini terdapat 1,1% berjenis kelamin laki-laki, kasus meninggal terbanyak yaitu pada tahun 2018 dengan 12 kasus 60,0%. Kesimpulan dari penelitian ini adalah kanker payudara umumnya di dominasi oleh perempuan namun tidak menutup kemungkinan terjadi pada laki-laki, usia 45-65 yang merupakan usia setengah baya atau lansia. Jadi diharapkan untuk selalu pemeriksaan rutin sebagai tahap pencegahan.
Kata kunci: umur; jenis kelamin; kanker payudara
m6A RNA Methylation Regulator YTHDF1 Correlated With Immune Microenvironment Predicts Clinical Outcomes and Therapeutic Efficacy in Breast Cancer
Authors: Hu Ying , Pan Qinwen , Wang Minghao , Ai Xiang , Yan Yuzhao , Tian Yuan , Jing Yuting , Tang Peng , Jiang Jun 
Published: August 2021

Objective: Increasing evidence highlights the roles of N6-methyladenosine (m6A) and its regulators in oncogenesis. Herein, this study observed the associations of m6A regulators with breast cancer.Methods: RNA-seq profiles of breast cancer were retrieved from the Cancer Genome Atlas (TCGA) database. The expression of m6A regulators was analyzed in tumor and normal tissues. Their expression correlations were analyzed by Spearson test. Overall survival (OS) analysis of these regulators was then presented. Gene set enrichment analysis (GSEA) was performed in high and low YTHDF1 expression groups. The correlations of YTHDF1 expression with immune cells and tumor mutation burden (TMB) were calculated in breast cancer samples. Somatic variation was assessed in high and low YTHDF1 expression groups.Results: Most of m6A regulators were abnormally expressed in breast cancer compared to normal tissues. At the mRNA levels, there were closely relationships between them. Among them, YTHDF1 up-regulation was significantly related to undesirable prognosis (p = 0.025). GSEA results showed that high YTHDF1 expression was associated with cancer-related pathways. Furthermore, YTHDF1 expression was significantly correlated with T cells CD4 memory activated, NK cells activated, monocytes, and macrophages. There were higher TMB scores in YTHDF1 up-regulation group than its down-regulation group. Missense mutation and non-sense mutation were the most frequent mutation types.Conclusion: Our findings suggested that dysregulated m6A regulator YTHDF1 was predictive of survival outcomes as well as response to immunotherapy of breast cancer, and were closely related to immune microenvironment.
Meta-Analysis of Renal Replacement Therapy for Burn Patients: Incidence Rate, Mortality, and Renal Outcome
Authors: Duan ZhiYu , Cai GuangYan , Li JiJun , Chen FengKun , Chen XiangMei 
Published: August 2021

Background: Renal replacement therapy (RRT) was often needed by some severe burn patients with acute kidney injury (AKI). The primary aim of this study was to review incidence rate and mortality of RRT in severe burn patients. Second aims were to review RRT complications and renal outcome.Methods: We searched multiple databases for studies published between 1 January 1960 and 31 December 2019. Studies about adult populations with burn injury, providing epidemiologic data on prevalence or mortality of RRT, were included.Results: A total of selected 57 studies, including 27,437 patients were enrolled in our analysis. The prevalence rates of RRT were 8.34% (95% CI 7.18–9.5%) in all burn patients and 37.05% (95% CI 29.85–44.24%) in AKI patients. The mortality of all burn patients with RRT was 65.52% (95% CI 58.41–72.64%). The prevalence rates of RRT in sample size≥100 group were 6.86% (95% CI 5.70–8.03%), which was lower than that of &lt;100 group (17.61%, 95% CI 13.39–21.82%). With the increase of TBSA, the prevalence of RRT may have the increasing trend. The prevalence rates of RRT in Asian group was 12.75% (95% CI 9.50–16.00%), which was higher than that of European (10.45%, 95% CI 7.30–13.61%) and North America group (5.61%, 95% CI 4.27–6.95%). The prevalence rates of RRT in 2010–2019 group was 12.22% (95% CI 10.09–14.35%), which was higher than that of 2009–2000 group (5.17%, 95% CI 2.88–7.46%). The prevalence rates of RRT in 1989 and before group was the lowest, which was 1.56% (95% CI 0–3.68%). However, there was no significant correlation between the year of publication and the mortality of burn patients with RRT. Dialysis-requiring AKI in burn patients could increases the risk of chronic kidney disease progression and end-stage renal disease. About 35% of RRT patients need to maintain haemodialysis temporarily, even if they survive and leave hospital.Conclusions: The prevalence rate of RRT is about 6–8%; approximately, one-third of burn patients with AKI need RRT. The prevalence rate of RRT increased over time, but the mortality did not change. The prevalence rates of RRT in Asian group was higher than that of European and North America group.
Identification of Key Genes Mutations Associated With the Radiosensitivity by Whole Exome Sequencing in Pancreatic Cancer
Authors: Hu Bin , Ma Xiumei , Huang Renhua , Wu Zheng , Lu Jun , Guo Yuntao , Tang Jianmin , Ma Chunhui , Ma Jun , Zhang Lei , Bai Yongrui 
Published: August 2021

BackgroundPancreatic cancer (PC) is one of the most lethal human cancers, and radiation therapy (RT) is an important treating option. Many patients diagnosed with PC do not achieve objective responses because of the existence of intrinsic and acquired radioresistance. Therefore, biomarkers, which predict radiotherapy benefit in PC, are eagerly needed to be identified.MethodsWhole-exome sequencing of six pancreatic ductal adenocarcinoma patients (PDAC) (three with a good response and three with a poor response) who had received radical surgery and then radiotherapy has been performed as standard of care treatment. Somatic and germline variants and the mutational signatures were analyzed with bioinformatics tools and public databases. Functional enrichment and pathway-based protein-protein interaction analyses were utilized to address the possibly mechanism in radioresistance. MTT, LDH, and colony formation assay were applied to evaluate cell growth and colony formation ability.ResultsIn the present study, somatic mutations located in 441 genes were detected to be radiosensitivity-related loci. Seventeen genes, including the Smad protein family members (SMAD3 and SMAD4), were identified to influence the radiosensitivity in PDAC. The SMAD3 and SMAD4 genes mutate differently between radiosensitive and radioresistant PDAC patients. Mutation of SMAD3 potentiates the effects of ionizing radiation (IR) on cell growth and colony formation in PDAC cells, whereas mutation of SMAD4 had the opposite effects. SMAD3 and SMAD4 regulate the radiosensitivity of PDAC, at least in part, by P21 and FOXO3a, respectively.ConclusionsThese results indicate that mutations of SMAD3 and SMAD4 likely cause the difference of response to radiotherapy in PDAC, which might be considered as the biomarkers and potential targets for the radiotherapy of pancreatic cancer.
Connections Between Perceived Social Support and the Body Image in the Group of Women With Diastasis Recti Abdominis
Authors: Izydorczyk Bernadetta , Walenista Wiktoria , Kamionka Agata , Lizińczyk Sebastian , Ptak Magdalena 
Published: August 2021

Background: The psychological features of the body image and the role of perceived social support for women with diastasis recti abdominis (DRAM) is significant for the treatment of this group of patients, but it is difficult to identify research on this topic. We aimed to search for similarities and differences between postpartum women with DRAM in terms of their psychological features of the body image and perceived social support from the partner, family and friends.Methods: Three hundred forty-five Polish women with DRAM were asked to fill the The Multidimensional Body-Self Relations Questionnaire (MBSRQ), The Multidimensional Scale of Perceived Social Support (MSPSS) and The Drawing Self-Assessment Sheet. Data analysis included the stepwise regression analysis and k-cluster analysis.Results: We identified several predictors in the group of women with DRAM. Social support of partner, family, and friends are the predictors of self-assessment of general body appearance. Social support of family is a predictor of self-assessment of the health of the body. Social support of friends is a predictor of self-esteem of weight and fear of gaining weight. Moreover, three clusters of women with DRAM were found. Type 1—women with DRAM with one child and low self-esteem of the general appearance of the body, low self-esteem of health condition of the body, high self-esteem of weight, and fear of weight gain, and low level of social support; Type 2—women with DRAM with three or more children and low self-esteem of the general appearance of the body, low self-esteem of health condition of the body, high self-esteem of weight and fear of weight gain, and high level of social support; and Type 3—women with DRAM with two children and high self-esteem for the general appearance of the body, high level of self-esteem for health of the body, low self-esteem of weight and fear of weight gain, and high levels of social support.Conclusions: Social support is a predictor of body image in women with DRAM, but there are other factors that influence body acceptance more in this group of women. Furthermore the three clusters featured in the study may help in treating women with DRAM.
Antimicrobial Activity and Action Mechanisms of Arg-Rich Short Analog Peptides Designed from the C-Terminal Loop Region of American Oyster Defensin (AOD)
Authors: Seo Jung-Kil , Kim Dong-Gyun , Lee Ji-Eun , Park Kwon-Sam , Lee In-Ah , Lee Ki-Young , Kim Young-Ok , Nam Bo-Hye 
Published: August 2021

American oyster defensin (AOD) was previously purified from acidified gill extract of the American oyster, Crassostrea virginica. AOD is composed of 38 amino acids with three disulfide bonds and exhibits strong antimicrobial activity against Gram-positive bacteria as well as significant activity against Gram-negative bacteria. Here, to develop promising peptides into antibiotic candidates, we designed five arginine-rich analogs (A0, A1, A2, A3, and A4), predicted their loop and extended strand/random structures—including nine amino acids and a disulfide bond derived from the C-terminus of AOD—and described their antimicrobial and cytotoxic effects, as well as their modes of action. In our experimental results, the A3 and A4 analogs exhibited potent antimicrobial activity against all test organisms—including four Gram-positive bacteria, six Gram-negative bacteria, and Candida albicans—without cell toxicity. A sequence of experiments, including a membrane permeabilization assay, DNA binding study, and DNA polymerization inhibition test, indicated that the two analogs (A3 and A4) possibly did not act directly on the bacterial membrane but instead interacted with intracellular components such as DNA or DNA amplification reactions. AOD analogs also showed strong bacterial inhibition activity in the plasma environment. In addition, analog-treated microbial cells clearly exhibited membrane disruption, damage, and leakage of cytoplasmic contents. Collectively, our results suggest that two analogs, A3 and A4, have potent antimicrobial activity via DNA interaction and have the potential for development into novel antimicrobial agents.
Perspektif Antropologi Kesehatan: Pengobatan Tradisional Cacar Air Pada Anak Di Minanga Kabupaten Tana Toraja
Authors: Nasaruddin Resky Purnamasari 
Published: August 2021

Toraja people, especially in Minanga, still strongly believe in traditional medicine which he believes is an alternative to cure diseases that cannot be treated with medical treatment alone. One of the diseases that often attacks children in Minanga, Bungtu Tangti sub-district, is chickenpox or puru. Chickenpox is a disease caused by a virus that attacks antibodies, especially for children. This disease is highly contagious, pandemic and seasonal. The mode of transmission is in the form of direct contact with patients through nasal droplets, or fluid in vesicles so that it can easily attack children whose immune power is still not strong. So that parents have the knowledge that he reconstructs into an action to prevent their children from getting chickenpox as early as possible and even if they have been affected, they can quickly treat it by utilizing the natural products around them. Through this research, the author intends to examine the knowledge of traditional medicine in the perspective of Health Anthropology. This study uses qualitative methods, observation and in-depth interviews through holistic understanding. The results of this study show that from the perspective of Health anthropology, it is found how people in Minanga have an understanding of traditional local medicine related to human behavior that has cultural knowledge related to disease, and how to treat disease and how to treat it to protect family health against chickenpox infection.

Masyarakat Toraja khususnya di Minanga masih sangat percaya dengan pengobatan tradisional yang diyakininya sebagai alternatif penyembuhan penyakit yang tidak bisa disembuhkan dengan pengobatan medis saja. Salah satu penyakit yang sering menyerang anak-anak di Minanga, Kecamatan Bungtu Tanti, adalah cacar air atau puru. Cacar air adalah penyakit yang disebabkan oleh virus yang menyerang antibodi, terutama untuk anak-anak. Penyakit ini sangat menular, pandemik dan musiman. Cara penularannya berupa kontak langsung dengan penderita melalui droplet hidung, atau cairan dalam vesikel sehingga mudah menyerang anak-anak yang daya tahan tubuhnya masih belum kuat. Agar para orang tua memiliki pengetahuan yang ia rekontruksi menjadi sebuah tindakan untuk mencegah anaknya terkena cacar air sedini mungkin dan bahkan jika sudah terkena dapat segera mengobatinya dengan memanfaatkan bahan alam yang ada disekitarnya. Melalui penelitian ini, penulis bermaksud untuk mengkaji pengetahuan pengobatan tradisional dalam perspektif Antropologi Kesehatan. Penelitian ini menggunakan metode kualitatif, observasi dan wawancara mendalam melalui pemahaman holistik. Hasil penelitian ini menunjukkan bahwa dari perspektif Antropologi Kesehatan, ditemukan bagaimana masyarakat Minanga memiliki pemahaman tentang pengobatan tradisional lokal terkait dengan perilaku manusia yang memiliki pengetahuan budaya terkait penyakit, serta cara pengobatan penyakit dan cara pengobatannya. untuk melindungi kesehatan keluarga dari infeksi cacar air.