bluuebunny/crossref_metadata_2025_split huggingface dataset:
Usability and Effectiveness of Immersive Virtual Grocery Shopping for Assessing Cognitive Fatigue in Healthy Controls: Protocol for a Randomized Controlled Trial
Authors: Holdnack James A , Brennan Patricia Flatley 
Published: June 2021

Background
Cognitive fatigue (CF) is a human response to stimulation and stress and is a common comorbidity in many medical conditions that can result in serious consequences; however, studying CF under controlled conditions is difficult. Immersive virtual reality provides an experimental environment that enables the precise measurement of the response of an individual to complex stimuli in a controlled environment.

Objective
We aim to examine the development of an immersive virtual shopping experience to measure subjective and objective indicators of CF induced by instrumental activities of daily living.

Methods
We will recruit 84 healthy participants (aged 18-75 years) for a 2-phase study. Phase 1 is a user experience study for testing the software functionality, user interface, and realism of the virtual shopping environment. Phase 2 uses a 3-arm randomized controlled trial to determine the effect that the immersive environment has on fatigue. Participants will be randomized into 1 of 3 conditions exploring fatigue response during a typical human activity (grocery shopping). The level of cognitive and emotional challenges will change during each activity. The primary outcome of phase 1 is the experience of user interface difficulties. The primary outcome of phase 2 is self-reported CF. The core secondary phase 2 outcomes include subjective cognitive load, change in task performance behavior, and eye tracking. Phase 2 uses within-subject repeated measures analysis of variance to compare pre- and postfatigue measures under 3 conditions (control, cognitive challenge, and emotional challenge).

Results
This study was approved by the scientific review committee of the National Institute of Nursing Research and was identified as an exempt study by the institutional review board of the National Institutes of Health. Data collection will begin in spring 2021.

Conclusions
Immersive virtual reality may be a useful research platform for simulating the induction of CF associated with the cognitive and emotional challenges of instrumental activities of daily living.

Trial Registration
ClinicalTrials.gov NCT04883359; http://clinicaltrials.gov/ct2/show/NCT04883359

International Registered Report Identifier (IRRID)
PRR1-10.2196/28073
Marie Cardinal Traduzida: A Trajetória internacional de seus escritos
Authors: Dietze Maitê 
Published: June 2021

O artigo apresenta o percurso da obra da escritora francófona Marie Cardinal, a fim de analisar a difusão das traduções de seus livros. Para tanto, essa contribuição se inicia com uma breve contextualização da vida e do trabalho da autora, relatando seus aspectos centrais e discorrendo sobre os eixos discursivos componentes de seus escritos. A seguir, retrata-se o mapeamento das traduções publicadas pelo mundo, considerado como panorama quantitativo que introduz a análise internacional do estado da arte da autora. Partindo desse levantamento, a análise tradutória enfoca o caso do livro mais vendido e traduzido para o maior número de línguas: Les mots pour le dire (1975); analisa-se também a situação de Autrement dit (1977) que, embora seja uma subsequência dessa obra e, portanto, diretamente relacionada a ela, teve repercussões divergentes. Tal análise toma como objeto os paratextos (génette, 1987) das traduções para inglês e português dos livros de Cardinal. Observando os dados presentes nos peritextos e epitextos, em nível preliminar e macroestrutural (lambert; van gorp, 1985), encontram-se informações indicativas da recepção dos livros na cultura de chegada lusófona e anglófona. Com essa pesquisa, considera-se que a obra de Cardinal constitui uma escrita particularmente maleável, podendo ser interpretada em prismas diversos; cada tradução analisada aponta, através dos paratextos, um direcionamento de leitura para o texto em questão. Supõe-se que projetos de traduções que almejem manter a maleabilidade característica da escritura da autora precisam ter em conta uma avaliação global e equilibrada dos aspectos identificados como fundamentais de seu discurso. O interesse da escritura de Cardinal para âmbitos como a crítica feminista, os estudos culturais e a psicanálise é explícito nos textos originais; pretende-se, enfim, partir desse levantamento histórico-crítico para desenvolver novos estudos, aprofundando a pesquisa sobre a contribuição de Cardinal em tais âmbitos, bem como propondo projetos de tradução inéditos e que tenham em vista esses interesses.
Tradução literária e variação linguística em One Christmas Eve, de Langston Hughes
Authors: Geaquinto PAGANINE Carolina , Moreira Fortunato Isadora 
Published: June 2021

Este trabalho apresenta algumas reflexões sobre a nossa tradução do conto One Christmas Eve, de Langston Hughes (1902-1967), parte da obra The Ways of White Folks (1934). Temos como objetivo analisar a possibilidade de representação de variedades linguísticas nos sistemas literários fonte e alvo (americano e brasileiro) e explorar soluções tradutórias para tais variedades, ligadas Ã representação de grupos de fala, compreendendo sua legitimidade, sistematicidades e entendendo que elas caracterizam os falantes no texto literário. São discutidas teorias da tradução que tratam de marcas de oralidade (BANDIA, 2015; ROSA, 2015) e de variação linguística em relação ao African American Vernacular English (AAVE) e ao português brasileiro (BAGNO, 2012; EZGETA, 2012; LABOV, 1972; LUCCHESI, 2009). Primeiramente, apresentamos o contexto de produção da obra e as questões raciais, sociais e ideológicas que este suscita. Além disso, discutimos alguns aspectos das fases literárias do autor e a influência da Harlem Renaisssance e do movimento modernista norte-americano na escrita do conto aqui apresentado e traduzido. Em seguida, examinamos as variedades linguísticas presentes no texto-fonte e alvo e os aspectos que orientaram nossas escolhas, tendo como princípio norteador marcar a alteridade no texto e evitar uma tradução que realize uma homogeneização dos modos de fala e que apague identidades veiculadas pela representação da linguagem falada no texto literário. Com isto, consideramos o ato de tradução como aquele que estabelece um texto em outra cultura a partir de uma reescrita do texto-fonte, um ato que vê a língua a partir de sua dimensão cultural e social. A partir disso, situamos a nossa prática tradutória a partir da perspectiva de que os tradutores têm um papel ativo e ativista frente Ã homogeneização das línguas e ao apagamento de identidades de grupos marginalizados ao decidirem por recriar a pluralidade de vozes textuais, tendo em vista a tradução como um lugar privilegiado em que duas instâncias se encontram e podem ser examinadas por uma abordagem analítica e crítica.
“Sim, há uma”: tradução e performance em português de “See-line woman”, a partir de uma interpretação de Nina Simone
Authors: Alves Ferreira Mendes Luciane 
Published: June 2021

“See-line Woman”, peça musical de tradição oral norte-americana, foi registrada em 1939, recolhida e reproduzida em diferentes performances orais, tais como as de Leslie Feist (2007), e Nina Simone (1964). Tomando como original a gravação constante no álbum Mississipi Goddam (1964), de Nina Simone, e evidenciando a dubiedade de som e sentido que o registro da letra ”“ tradução da oralidade ”“ pode evidenciar, abordarei alguns problemas atinentes Ã tradução de canção para performance quando me deparo com um original que tensiona a letra da canção registrada de maneira distinta Ã s outras versões oralizadas de 1939 e de 2007.
Influence of supramarginal resection on survival outcomes after gross-total resection of IDH–wild-type glioblastoma
Authors: Vivas-Buitrago Tito , Domingo Ricardo A. , Tripathi Shashwat , De Biase Gaetano , Brown Desmond , Akinduro Oluwaseun O. , Ramos-Fresnedo Andres , Sabsevitz David S. , Bendok Bernard R. , Sherman Wendy , Parney Ian F. , Jentoft Mark E. , Middlebrooks Erik H. , Meyer Fredric B. , Chaichana Kaisorn L. , Quinones-Hinojosa Alfredo 
Published: June 2021

OBJECTIVE
The authors’ goal was to use a multicenter, observational cohort study to determine whether supramarginal resection (SMR) of FLAIR-hyperintense tumor beyond the contrast-enhanced (CE) area influences the overall survival (OS) of patients with isocitrate dehydrogenase–wild-type (IDH-wt) glioblastoma after gross-total resection (GTR).

METHODS
The medical records of 888 patients aged ≥ 18 years who underwent resection of GBM between January 2011 and December 2017 were reviewed. Volumetric measurements of the CE tumor and surrounding FLAIR-hyperintense tumor were performed, clinical variables were obtained, and associations with OS were analyzed.

RESULTS
In total, 101 patients with newly diagnosed IDH-wt GBM who underwent GTR of the CE tumor met the inclusion criteria. In multivariate analysis, age ≥ 65 years (HR 1.97; 95% CI 1.01–2.56; p < 0.001) and contact with the lateral ventricles (HR 1.59; 95% CI 1.13–1.78; p = 0.025) were associated with shorter OS, but preoperative Karnofsky Performance Status ≥ 70 (HR 0.47; 95% CI 0.27–0.89; p = 0.006), MGMT promotor methylation (HR 0.63; 95% CI 0.52–0.99; p = 0.044), and increased percentage of SMR (HR 0.99; 95% CI 0.98–0.99; p = 0.02) were associated with longer OS. Finally, 20% SMR was the minimum percentage associated with beneficial OS (HR 0.56; 95% CI 0.35–0.89; p = 0.01), but > 60% SMR had no significant influence (HR 0.74; 95% CI 0.45–1.21; p = 0.234).

CONCLUSIONS
SMR is associated with improved OS in patients with IDH-wt GBM who undergo GTR of CE tumor. At least 20% SMR of the CE tumor was associated with beneficial OS, but greater than 60% SMR had no significant influence on OS.
Supraspinal functional and structural plasticity in patients undergoing surgery for degenerative cervical myelopathy
Authors: Wang Chencai , Ellingson Benjamin M. , Islam Sabah , Laiwalla Azim , Salamon Noriko , Holly Langston T. 
Published: June 2021

OBJECTIVE
The aim of this study was to investigate cerebral reorganization, both structurally and functionally, occurring in patients with degenerative cervical myelopathy (DCM) after surgical decompression.

METHODS
In the current observational study of 19 patients, high-resolution T1-weighted structural MRI and resting-state functional MRI scans were obtained pre- and postoperatively in patients with DCM and healthy controls (HCs). The resting-state functional MRI data were utilized to perform region-of-interest (ROI)–to-ROI and ROI-to-voxel functional connectivity (FC) analysis and were similarly compared between and within cohorts. Macroscopic structural plasticity was evaluated by assessing for changes in cortical thickness within the DCM cohort after decompression surgery.

RESULTS
Prior to surgery, FC patterns were significantly different between DCM patients and HCs in cerebral areas responsible for postural control, motor regulation, and perception and integration of sensory information. Significantly stronger FC between the cerebellum and frontal lobes was identified in DCM patients postoperatively compared with DCM patients preoperatively. Additionally, increased FC between the cerebellum and primary sensorimotor areas was found to be positively associated with neurological improvement in patients with DCM. No macroscopic structural changes were observed in the DCM patients after surgery.

CONCLUSIONS
These results support the authors’ hypothesis that functional changes within the brain are associated with effective postoperative recovery, particularly in regions associated with motor regulation and with perception and integration of sensory information. In particular, increased FC between the cerebellum and the primary sensorimotor after surgery appears to be associated with neurological improvement. Macroscopic morphological changes may be too subtle to be detected within 3 months after surgery.
Investigating the Effect of the Asayar Smart Program on Ambulance Arrival Time at the Scene
Authors: Ranjbar Mahdi , Gaeeni Mina , Parvaresh Mohammad , Hamta Amir 
Published: June 2021

Background Communication is important in pre-hospital emergencies and the faster and more accurately it is done, the more effective the treatment process will be. With the advancement of technology, a mobile phone system equipped with the Asayar smart program replaces paper methods. By creating an online connection between doctors, technicians and treatment centres, Asayar will increase the speed of the treatment and transfer of the patient to hospital. One of the most important challenges of this program is the interruption of internet connections and the reduction of internet speed. This study was designed to investigate the effect of the Asayar smart program on ambulance arrival time at the scene and compare it with paper methods. Methods A descriptive-analytical cross-sectional study in the city of Isfahan in Iran, with a sample number of 700 missions performed by the paper registration method in 2017, and 230 missions registered by Asayar program method in 2018. The Propensity score matching method was used to analyse the data. Results The findings of the study showed that the use of the Asayar smart program in the pre-hospital emergency department of Isfahan has reduced times for ambulance arrival to the scene. Conclusion Using the Asayar smart program in a pre-hospital emergency can increase patient coordination and management.
Coping Mechanism and Professional Quality of Life in Northeast Texas Ems Personnel during the Covid-19 Pandemic: An Exploratory Study
Authors: Miller Anastasia , Brown Lee 
Published: June 2021

Introduction The purpose of this study was to conduct an exploratory evaluation of employee professional quality of life and factors associated with it at an emergency medical service (EMS) agency in northeast Texas in the United States. Initially, we intended to evaluate typical day-to-day factors, however we ended up capturing these factors during the unique environment of the COVID-19 pandemic. Methods We conducted an exploratory cross-sectional survey at an EMS agency in northeast Texas in November 2020. Surveys were web-based and anonymous. They included the ProQOL 5, the Survey of Perceived Organizational Support, the Brief Resilience Survey, the RAND Social Support Survey Instrument, the Kessler-6, the Workplace Incivility Scale-Revised, the General Self-Efficacy Scale and the Brief Cope Scale. Results The survey had a response rate of 19% (38 participants). Findings suggest a positive relationship between utilising religion as a coping mechanism and higher compassion satisfaction. There was also a relationship associated between increased perceived organisational support leading to an increase in compassion satisfaction. The most significant predictors of burnout were two different coping mechanisms. Those who relied more heavily on behavioral disengagement and those who employed humour as a coping mechanism displayed average increased levels of burnout. Finally, those who experienced workplace incivility and those who relied on self-blame as a coping mechanism experienced on average higher levels of secondary traumatic stress. Conclusion This study adds to the limited literature examining coping mechanisms, stress and burnout in EMS personnel. It is also unique for examining how EMS personnel are coping with stress during a prolonged pandemic.
Early Deformation of Deep Brain Stimulation Electrodes Following Surgical Implantation: Intracranial, Brain, and Electrode Mechanics
Authors: Chapelle Frédéric , Manciet Lucie , Pereira Bruno , Sontheimer Anna , Coste Jérôme , El Ouadih Youssef , Cimpeanu Ruxandra , Gouot Dimitri , Lapusta Yuri , Claise Béatrice , Sautou Valérie , Bouattour Yassine , Marques Ana , Wohrer Adrien , Lemaire Jean-Jacques 
Published: June 2021

IntroductionAlthough deep brain stimulation is nowadays performed worldwide, the biomechanical aspects of electrode implantation received little attention, mainly as physicians focused on the medical aspects, such as the optimal indication of the surgical procedure, the positive and adverse effects, and the long-term follow-up. We aimed to describe electrode deformations and brain shift immediately after implantation, as it may highlight our comprehension of intracranial and intracerebral mechanics.Materials and MethodsSixty electrodes of 30 patients suffering from severe symptoms of Parkinson’s disease and essential tremor were studied. They consisted of 30 non-directional electrodes and 30 directional electrodes, implanted 42 times in the subthalamus and 18 times in the ventrolateral thalamus. We computed the x (transversal), y (anteroposterior), z (depth), torsion, and curvature deformations, along the electrodes from the entrance point in the braincase. The electrodes were modelized from the immediate postoperative CT scan using automatic voxel thresholding segmentation, manual subtraction of artifacts, and automatic skeletonization. The deformation parameters were computed from the curve of electrodes using a third-order polynomial regression. We studied these deformations according to the type of electrodes, the clinical parameters, the surgical-related accuracy, the brain shift, the hemisphere and three tissue layers, the gyration layer, the white matter stem layer, and the deep brain layer (type I error set at 5%).ResultsWe found that the implanted first hemisphere coupled to the brain shift and the stiffness of the type of electrode impacted on the electrode deformations. The deformations were also different according to the tissue layers, to the electrode type, and to the first-hemisphere-brain-shift effect.ConclusionOur findings provide information on the intracranial and brain biomechanics and should help further developments on intracerebral electrode design and surgical issues.
Evolution of Pneumatic Tsunami Simulators–From Concept to Proven Experimental Technique
Authors: Chandler Ian , Allsop William , Robinson David , Rossetto Tiziana 
Published: June 2021

This paper describes the evolution through three generations of pneumatic Tsunami Simulators for physical model tests of realistic tsunami. The pneumatic method, originally developed for tidal modeling in the Fifties, has been modernized to generate extraordinarily long waves in a controlled manner, with accurate reproduction of recorded free-surface tsunami field data. The paper describes how the simulator designs were developed and how they performed in the laboratory. Example results are presented from selected research studies that have validated their performance and then used to quantify tsunami effects. Having described each of the first, second, and third generation Tsunami Simulators, the paper discusses how to calibrate the wave generation control to model tsunami with model periods 20–240 s duration (equivalent to 2–20 min duration in prototype at 1:50 scale), many of which are far too long to “fit into the test flume.” The evolution of a composite approach to wave calibration is described with examples from second and third generation devices, demonstrated by successful simulation of both the 2004 Boxing Day, and the 2011 Great Eastern Japan (Tohoku) Tsunami at 1:50 scale.
Genotype Profile of Global EYS-Associated Inherited Retinal Dystrophy and Clinical Findings in a Large Chinese Cohort
Authors: Xu Ke , Chen De-Fu , Chang Haoyu , Shen Ren-Juan , Gao Hua , Wang Xiao-Fang , Feng Zhuo-Kun , Zhang Xiaohui , Xie Yue , Li Yang , Jin Zi-Bing 
Published: June 2021

PurposeThe aim of this study was to probe the global profile of the EYS-associated genotype-phenotype trait in the worldwide reported IRD cases and to build a model for predicting disease progression as a reference for clinical consultation.MethodsThis retrospective study of 420 well-documented IRD cases with mutations in the EYS gene included 39 patients from a genotype-phenotype study of inherited retinal dystrophy (IRD) conducted at the Beijing Institute of Ophthalmology and 381 cases retrieved from global reports. All patients underwent ophthalmic evaluation. Mutations were revealed using next-generation sequencing, followed by Sanger DNA sequencing and real-time quantitative PCR analysis. Multiple regression models and statistical analysis were used to assess the genotype and phenotype characteristics and traits in this large cohort.ResultsA total of 420 well-defined patients with 841 identified mutations in the EYS gene were successfully obtained. The most common pathogenic variant was a frameshift c.4957dupA (p.S1653Kfs∗2) in exon 26, with an allele frequency of 12.7% (107/841), followed by c.8805C &gt; A (p.Y2935X) in exon 43, with an allele frequency of 5.9% (50/841). Two new hot spots were identified in the Chinese cohort, c.1750G &gt; T (p.E584X) and c.7492G &gt; C (p.A2498P). Several EYS mutation types were identified, with CNV being relatively common. The mean age of onset was 20.54 ± 11.33 (4–46) years. Clinical examinations revealed a typical progression of RPE atrophy from the peripheral area to the macula.ConclusionThis large global cohort of 420 IRD cases, with 262 distinct variants, identified genotype-phenotype correlations and mutation spectra with hotspots in the EYS gene.
Left Anterior Fascicular Block After Transcatheter Closure of Ventricular Septal Defect in Children
Authors: Wu Zhijun , Yang Penghui , Xiang Ping , Ji Xiaojuan , Tian Jie , Li Mi 
Published: June 2021

Background: Arrhythmia is the most common complication after transcatheter closure of a ventricular septal defect (VSD). However, the effects of postprocedural left anterior fascicular block are not clear. This study presents the clinical characteristics, prognosis, and related risk factors of left anterior fascicular block after transcatheter closure of a VSD in children.Methods: The clinical and follow-up data of the patients in the Heart Center of Children's Hospital of Chongqing Medical University from June 2009 to October 2018 were reviewed. And 30 cases were eligible out of all 1,371 cases.Results: An electrocardiogram showed a left anterior fascicular block within 3 days, and most patients gradually returned to normal within 1–2 years, showing a dynamic change. Left ventricular end-diastolic dimension Z-score ranged from −2 to 2 in all children, and no decrease of left ventricular ejection fraction was found in all children. The high ratio between VSD size and body surface area [p &lt; 0.05, odds ratio (OR) 2.6, 95% CI: 1.136–6.113] and large diameter difference between the occluder size and VSD size (p &lt; 0.05, OR 2.1, 95% CI: 1.036–4.609) were independent risk factors for postprocedural left anterior fascicular block.Conclusions: The incidence of postprocedural left anterior fascicular block is not that low, and the overall prognosis is quite good at the current follow-up stage. No progressive severity has been found, such as complete left bundle branch block, double (triple) bundle branch block, and atrioventricular block, to have an influence on cardiac systolic and diastolic function.