bluuebunny/crossref_metadata_2025_split huggingface dataset:
A semi‐implicit material point method based on fractional‐step method for saturated soil
Authors: Kularathna Shyamini , Liang Weijian , Zhao Tianchi , Chandra Bodhinanda , Zhao Jidong , Soga Kenichi 
Published: March 2021

AbstractIn this paper, a new formulation of material point method (MPM) to model coupled soil deformation and pore fluid flow problems is presented within the framework of the theory of porous media. The saturated porous medium is assumed to be consisting of incompressible pore fluid and deformable soil skeleton made up of incompressible solid grains. The main difference of the proposed MPM algorithm is the implicit treatment of pore‐water pressure which satisfies its incompressibility internal constraint. The resulting solid‐fluid coupled equations are solved by using a splitting algorithm based on the Chorin's projection method. The splitting algorithm helps to mitigate numerical instabilities at the incompressibility limit when equal‐order interpolation functions are used. The key strengths of the proposed semi‐implicit coupled MPM formulation is its capability to reduce pressure oscillations as well as to increase the time step size, which is independent of the fluid incremental strain level and the soil permeability. The proposed semi‐implicit MPM is validated by comparing the numerical results with the analytical solutions of several numerical tests, including 1D and 2D plane‐strain consolidation problems. To demonstrate the capability of the proposed method in simulating practical engineering problems involving large deformations, a hydraulic process leading to slope failure is studied, and the numerical result is validated by the monitored data.
The information needs of people with COPD—The holistic approach with special reference to gender and time since diagnosis
Authors: Siltanen Hannele , Aine Tiina , Huhtala Heini , Kaunonen Marja , Paavilainen Eija 
Published: March 2021

AbstractAimsThe aim of this study was to determine what kinds of unmet information needs people with COPD have and whether there are differences in information needs between genders or based on the time since COPD diagnosis.DesignA descriptive cross‐sectional study.MethodsData on people with COPD (N = 169) were collected from a two‐part questionnaire distributed via website. On the first part, information needs concerning the medical aspects of self‐management were measured by the Lung Information Needs Questionnaire (LINQ). On the second part, which was developed specifically for this study, a more holistic view of self‐management counselling was sought. Statistical methods were used to analyse the data.ResultsThe respondents had wide‐ranging information needs in many areas of COPD self‐management. The most often reported areas of unmet information needs included exacerbations, diet, fatigue, stress and anxiety, palliative care and sexual life. The information needs varied by gender and time since COPD diagnosis.
Sex steroids and adiposity in a prospective observational cohort of youth
Authors: Kim Catherine , Harrall Kylie K. , Glueck Deborah H. , Dabelea Dana 
Published: March 2021

AbstractObjectiveAdiposity, particularly visceral adipose tissue (VAT), predicts adverse cardiovascular risk factor profiles in children as well as adults. Although endogenous sex steroids likely influence VAT in adults, such an association has not been established in youth. The association between childhood and adolescent sex steroids with adiposity, specifically VAT, was examined before and after adjustment for other hormone changes.MethodsThese analyses examined longitudinal associations between sex steroids (testosterone, estradiol, dehydroepiandrosterone [DHEA]) and magnetic resonance imaging assessments of VAT in 418 children, 49% of whom were non‐White, at approximately 10 years old at Visit 1 (V1) and 17 years old at Visit 2 (V2). Linear mixed effects models adjusted for maternal education, household income, child caloric intake, physical activity, fasting insulin and leptin, and hepatic fat fraction. Differences in associations by race and pubertal stage were also assessed.ResultsAt V1, mean body mass index (BMI) for boys was 19.1 (4.7) kg/m2 and for girls was 18.5 (4.1) kg/m2. At V2, mean BMI for boys was 23.7 (5.5) kg/m2 and for girls was 23.6 (5.7) kg/m2. For each ng/dl (0.035 nmol/L) increase in testosterone at V1, there was a 0.25 cm2 increase in concurrent and future VAT in non‐White (p = 0.04) but not White girls (p = 0.78). Higher levels of testosterone and DHEA at V1 were associated with greater concurrent and future VAT at V2. These associations were consistent regardless of pubertal stage. In boys, higher testosterone predicted higher future VAT but lower concurrent VAT. Estradiol and DHEA did not predict future VAT in boys. In girls, DHEA predicted future subcutaneous adipose tissue (SAT), and no sex steroids predicted future SAT in boys.ConclusionsTestosterone levels predict VAT in boys and girls, and DHEA predicts VAT in girls, even after adjustment for other hormone changes.
In‐situ investigation of dielectric properties and reaction kinetics of a glass‐fiber‐reinforced epoxy composite material using dielectric analysis
Authors: Yan Shuang , Zeizinger Harald , Merten Clemens , Schmauder Siegfried 
Published: March 2021

AbstractMonitoring the curing behavior of a thermosetting material is a key issue for ensuring a stable manufacturing process (e.g., injection molding). Dielectric analysis (DEA), which is applicable for online‐monitoring, is used to investigate the curing behavior of a glass‐fiber‐reinforced epoxy molding compound. At first, the influences of experimental settings (pressure, temperature, and frequency) on dielectric responses (dielectric loss and ion viscosity) are characterized in a fully crosslinked material. Results show a significant impact of temperature and frequency on dielectric responses. Furthermore, DEA is combined with differential scanning calorimetry (DSC) to investigate dielectric properties depending on crosslink density under non‐isothermal and isothermal conditions. The results show that DEA can detect cure changes only for a crosslink density <80%. Finally, reaction kinetics, which can predict the crosslink density, is derived using DSC and validated through DEA for determining the best suitable kinetic expression for the investigated material. The crosslink density, estimated by reaction kinetics, can be correlated with the dielectric properties.
Extracellular vesicles in the transfusion medicine field: The potential of proteomics
Authors: Hermida‐Nogueira Lidia , García Ángel 
Published: March 2021

AbstractIn transfusion centres, blood components are divided and stored following specific guidelines. The storage temperature and time vary among the blood cells but all of them release extracellular vesicles (EVs) under blood bank conditions. The clinical impact of such vesicles in blood components for transfusion is an object of debate, but should be considered and is being investigated. In this context, proteomics is an excellent tool to study the cargo and composition of EVs derived from red blood cells and platelets, since such vesicles are enriched in lipids and proteins. The development of quantitative mass spectrometry techniques and the evolution of bioinformatics have allowed the identification of novel EVs biomarkers for different diseases. In this context, the application of high coverage proteomic tools to the analysis of EVs in the transfusion medicine field would provide information about storage lesions and possible transfusion adverse reactions. This viewpoint article approaches the potential of proteomics to investigate the impact of EVs in blood bank transfusion components, especially red blood cells and platelets.
Anti‐TIF1γ antibody‐positive dermatomyositis associated with durvalumab administration in a patient with lung and oesophageal cancers
Authors: Imai Ryosuke , Ikemura Sumie , Jinta Torahiko 
Published: March 2021

AbstractWe report a case of anti‐transcriptional intermediary factor 1γ (TIF1γ) antibody‐positive dermatomyositis following durvalumab treatment. The patient was successfully treated with pulse steroid therapy, high‐dose intravenous immunoglobulin (IVIg), and tacrolimus. Durvalumab may induce dermatomyositis, and early diagnosis and aggressive therapy are crucial to prevent severe dermatomyositis, which is potentially treatable.
Are current practices of yak herdsmen adequate to combat Coenurosis in Laya Bhutan?
Authors: Wangdi Yeshi , Wangchuk Kesang 
Published: March 2021

AbstractBackgroundCoenurosis, known commonly as gid, is caused by a tapeworm Taenia multiceps. It is a disease of small ruminants globally but also occurs in large ruminants, especially in yak in the Himalaya. Gid is a pathological condition in young yaks, mostly below 3 years of age. The infected animal displays a circling movement with the head tilting towards the location of the cyst of a tapeworm on the cerebral surface of the brain.ObjectiveWe conducted a study with the primary aim to gain an insight into yak herdsmen's practices to manage Coenurosis in the Laya administrative block of Bhutan.MethodsAll seven villages of Laya were included for sampling. Seventy‐five out of 182 households owned yaks, and 54 yak‐owning households were selected randomly. The government livestock officials of nine yak‐rearing highland districts were also included in the study. A cross‐sectional study was conducted based on a questionnaire survey and focussed mainly on herdsmen's practices to manage gid. Two sets of questionnaires were used for yak herders and livestock officials. Each predesigned questionnaire was semi‐structured and consisted of both open– and closed‐ended questions.ResultsThe study revealed gid as a major cause of yak mortality. Gid occurred more in winter during migration and most herders lost one to three yaks annually. Herdsmen kept an average of two watchdogs and dewormed them once annually. Similarly, calves were also dewormed once annually. The carcasses of dead yaks were fed to dogs. Livestock officials were optimistic about controlling the disease in the future, despite the yak areas being difficult to access. Most herders had not attended the gid awareness programme. The animal health worker visited herds once annually. In absence of animal health workers, most herdsmen resorted to different practices to treat affected yaks –the most common practice being surgery. Gid was mentioned to harm herdsmen's economy.ConclusionsThe study concluded that for effective management of gid in Laya, livestock agencies must create more awareness on gid, increase the frequency of visits by animal health workers to yak herds, and increase the frequency of deworming of watchdogs and calves.
Seroprevalence and risk factors for foot‐and‐mouth disease in cattle in Baghlan Province, Afghanistan
Authors: Osmani Arash , Robertson Ian Duncan , Habib Ihab 
Published: March 2021

SummaryA serological study of 376 cattle from 198 herds and a concurrent survey of farmers were undertaken in 53 villages in Khinjan, Doshi and Puli Khumri districts of Baghlan province, Afghanistan to determine the seroprevalence of Foot and Mouth Disease (FMD) and to identify risk factors for seropositive herds. A total of 419 cases of FMD were reported by the farmers in the year preceding the survey. The animal‐level population seroprevalence was estimated at 42.0% (95% CI, 37.0–47.2). The seroprevalence increased with age in the sampled cattle (<2 years ‐ 30.4%, 2–6 years ‐ 40.3% and >6 years ‐ 52.2%). Herds were more likely to be seropositive if the farmers: had purchased cattle in the year prior to the survey (OR = 2.6; 95% CI, 1.37–4.97); purchased ruminants from unknown (potentially risky) sources (OR = 2.13; 95% CI, 1.13–4.03); and sold milk to the market (OR = 1.99; 95% CI, 1.09–3.63). Herds that had been vaccinated had a lower odds of being seropositive (OR = 0.33; 95% CI, 0.68–0.66). This was the first epidemiological study of FMD in Baghlan province and the findings provide valuable direction for disease control on FMD in this and other provinces in Afghanistan.
Evaluation of the damage caused by in vitro culture and cryopreservation to dermal fibroblasts derived from jaguars: An approach to conservation through biobanks
Authors: Silva Maria B. , Praxedes Érika A. , Borges Alana A. , Oliveira Lhara R. M. , Nascimento Matheus B. , Silva Herlon V. R. , Silva Alexandre R. , Pereira Alexsandra F. 
Published: March 2021

AbstractEx‐situ conservation strategies such as the formation of somatic cell banks are valuable tools for the conservation of jaguars, whose population has been declining in recent years. Once properly established, these cells can be successfully leveraged for future applications. We aimed to assess the effects of in vitro culture and cryopreservation on the establishment of fibroblasts derived from jaguars. Initially, we identified five dermal fibroblastic lines using morphology and immunophenotyping assays; these lines were then subjected to two experiments. In the first experiment, the viability, metabolism, and proliferative activity of cells at different passages (first, third, and tenth) were evaluated. In the second experiment, the cells were cryopreserved and the levels of reactive oxygen species (ROS), mitochondrial membrane potential (ΔΨm) and apoptosis were evaluated after one, three, and ten passages. Noncryopreserved cells were used as controls. The in vitro culture after first, third, and tenth passages and cryopreservation conditions did not affect the proliferative activity and viability. However, cells cultured until tenth passage and frozen/thawed cells showed reduced metabolism. In addition, cryopreserved cells showed higher levels of intracellular ROS and altered ΔΨm when compared with those of noncryopreserved cells. Finally, frozen/thawed cells cultured after ten passages showed reduced proliferative activity and number of viable cells than did frozen/thawed cells cultured after one and three passages. In summary, we have shown that viable fibroblasts can be established from jaguar skin and that although these cells do not show altered viability and proliferative activity, they do undergo damage during extended culture and cryopreservation.
GIS-Based Assessment of Solar Energy Harvesting Sites and Electricity Generation Potential in Zambia
Authors: Mwanza Mabvuto , Ulgen Koray 
Published: March 2021

AbstractLand and environment are some of limited nature resource for any particular country and requires best use. Therefore, for sustainable energy generation it is often important to maximize land use and avoid or minimize environmental and social impact when selecting the potential locations for solar energy harvesting. This chapter presents an approach for identifying and determining the potential sites and available land areas for solar energy harvesting. Hence, the restricting and enhancing parameters that influence sites selection based on international regulation have been imposed to the Laws of Zambia on environmental protection and pollution control legislative framework. Thus, both international regulations and local environmental protection and pollution control legislative have been used for identifying the potential sites and evaluating solar PV electricity generation potential in these potential sites. The restricting parameters were applied to reduce territory areas to feasible potential sites and available areas that are suitable for solar energy harvesting. The assessment involved two different models: firstly the assessment of potential sites and mapping using GIS, and secondly, evaluation of the available suitable land areas and feasible solar PV electricity generation potential in each provinces using analytical methods. The total available suitable area of the potential sites is estimated at 82,564.601 km2 representing 10.97% of Zambia’s total surface area. This potential is equivalent to 10,240.73 TWh annual electricity generation potential with potential to reduce CO2 emissions in the nation and achieve SDGs. The identification of potential sites and solar energy will help improve the understanding of the potential solar energy can contribute to achieving sustainable national energy mix in Zambia. Furthermore, it will help the government in setting up tangible energy targets and effective integration of solar PV systems into national energy mix.
Examining the Early Modern Canon: The English Short Title Catalogue and Large-Scale Patterns of Cultural Production
Authors: Tolonen Mikko , Hill Mark J. , Ijaz Ali Zeeshan , Vaara Ville , Lahti Leo 
Published: March 2021

AbstractThis chapter presents the findings of an ongoing digital project of the Helsinki Computational History Group at Helsinki Centre for Digital Humanities (HELDIG) focused on the history of eighteenth-century book publication. The authors have created a historical-biographical database based onThe English Short-Title Catalogue(ESTC), a standard source for analytical bibliographic research, and extracted a data-driven canon which considers changes over time, subject-topics, top-works, authors, publishers, publication place, and materiality. This chapter provides both methodological and historical insights into the development of print and demonstrates the huge analytical potential of harmonized metadata catalogs. While quantitative analyses of the book trade were attempted before, they did not engage with the complex process of canon formation at such a large scale. The authors’ work highlights the formative role played by publishers in this process and the epistemological shift started at the end of the seventeenth century, when religious works were increasingly replaced by literary works. As the authors argue, this shift in the production and consumption of print allowed for a reinvention of the canon during the eighteenth century.
Outliers, Connectors, and Textual Periphery: John Dennis’s Social Network in The Dunciad in Four Books
Authors: Baird Ileana 
Published: March 2021

AbstractThis chapter uses social network analysis to visualize the fields of relations involving John Dennis, the most important critic of the first half of the eighteenth century, with the other protagonists in Alexander Pope’s satire, The Dunciad in Four Books (1743). By using visualizations generated by GraphViz, a program that creates topological graphs from sets of dyadic relations, and ShivaGraph, a tool that helps visualize large networks and navigate through them as through a map, this chapter brings to light data that is structurally embedded in the poem but not immediately legible given the large amount and complexity of information. In Dennis’s case, they reveal the competing stories told by the poem and the apparatus and the critic’s main role as the uncrowned king of The Dunciad’s textual periphery. These visualizations also highlight Dennis’s essential position as a network connector, his camp affiliations, the role played by peripheral characters in the plot network of the poem, and the main dunces targeted by Pope, or the poem’s “hall of infamy.”
Genomic Imprinting
Authors: Paro Renato , Grossniklaus Ueli , Santoro Raffaella , Wutz Anton 
Published: March 2021

AbstractA typical cell contains two sets of chromosomes: one that was inherited from the mother, the other from the father. Usually, autosomal alleles are expressed at similar levels from the maternally and paternally inherited chromosomes. This chapter is dedicated to an exception of this rule: the expression of genes that are regulated by genomic imprinting depends on the parental origin of the allele, leading to the non-equivalence of maternal and paternal genomes. Genomic imprinting is a paradigm of epigenetic gene regulation as genetically identical alleles can exist in two expression states within the same nucleus. The imprints marking the parental alleles are established in the parental germline, maintained during the development of the offspring, but reset before they are passed on to the next generation. In mammals, the primary imprint is usually a differentially methylated region at the locus but there are also examples where histone modifications mark the parental alleles. Many imprinted genes play important roles for development and are associated with human disease. Interestingly, genomic imprinting evolved independently in mammals and seed plants and similar mechanisms have been recruited to regulate imprinted expression in the two kingdoms. We will discuss evolutionary constraints that could have led to the evolution of genomic imprinting in these seemingly disparate lineages.
Epigenetics and Cancer
Authors: Paro Renato , Grossniklaus Ueli , Santoro Raffaella , Wutz Anton 
Published: March 2021

AbstractAlterations in chromatin function and epigenetic mechanisms are a hallmark of cancer. The disruption of epigenetic processes has been linked to altered gene expression and to cancer initiation and progression. Recent cancer genome sequencing projects revealed that numerous epigenetic regulators are frequently mutated in various cancers. This information has not only started to be utilized as prognostic and predictive markers to guide treatment decisions but also provided important information for the understanding of the molecular mechanisms of epigenetic regulation in both physiological and pathological conditions. Furthermore, the reversible nature of epigenetic aberrations has led to the emergence of the promising field of epigenetic therapy that has already provided new therapeutic options for patients with malignancies characterized by epigenetic alterations, laying the basis for new and personalized medicine.
Renormalization of twisted Ramond fields in D1-D5 SCFT2
Authors: Lima A. A. , Sotkov G. M. , Stanishkov M. 
Published: March 2021

Abstract
We explore the n-twisted Ramond sector of the deformed two-dimensional $$ \mathcal{N} $$
N
= (4, 4) superconformal (T4)N/SN orbifold theory, describing bound states of D1-D5 brane system in type IIB superstring. We derive the large-N limit of the four-point function of two R-charged twisted Ramond fields and two marginal deformation operators at the free orbifold point. Specific short-distance limits of this function provide several structure constants, the OPE fusion rules and the conformal dimensions of a few non-BPS operators. The second order correction (in the deformation parameter) to the two-point function of the Ramond fields, defined as double integrals over this four-point function, turns out to be UV-divergent, requiring an appropriate renormalization of the fields. We calculate the corrections to the conformal dimensions of the twisted Ramond ground states at the large-N limit. The same integral yields the first-order deviation from zero of the structure constant of the three-point function of two Ramond fields and one deformation operator. Similar results concerning the correction to the two-point function of bare twist operators and their renormalization are also obtained.
Artificial proto-modelling: building precursors of a next standard model from simplified model results
Authors: Waltenberger Wolfgang , Lessa André , Kraml Sabine 
Published: March 2021

AbstractWe present a novel algorithm to identify potential dispersed signals of new physics in the slew of published LHC results. It employs a random walk algorithm to introduce sets of new particles, dubbed “proto-models”, which are tested against simplified-model results from ATLAS and CMS (exploiting the SModelS software framework). A combinatorial algorithm identifies the set of analyses and/or signal regions that maximally violates the SM hypothesis, while remaining compatible with the entirety of LHC constraints in our database. Demonstrating our method by running over the experimental results in the SModelS database, we find as currently best-performing proto-model a top partner, a light-flavor quark partner, and a lightest neutral new particle with masses of the order of 1.2 TeV, 700 GeV and 160 GeV, respectively. The corresponding globalp-value for the SM hypothesis ispglobal≈0.19; by construction no look-elsewhere effect applies.