bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerebral Microbleeds With Atrial Fibrillation After Ablation Therapy
Authors: Hirata Yoshinori , Kato Natsuko , Nakamura Naoko , Muraga Kanako , Shindo Akihiro , Matsuura Keita , Ii Yuichiro , Shiga Mariko , Tabei Ken-ichi , Satoh Masayuki , Fukuma Tomoyuki , Kagawa Yoshihiko , Fujita Satoshi , Kogue Ryouta , Umino Maki , Maeda Masayuki , Sakuma Hajime , Dohi Kaoru , Tomimoto Hidekazu 
Published: September 2021

Abstract
Background: The prevalence of cerebral microbleeds (CMBs) is significantly higher in patients with atrial fibrillation (AF) than in those without AF. CMBs in patients with AF have been reported to be primarily of the lobar type, but the exact cause of this remains unknown. We investigated the possibility that hemorrhagic transformation of embolic microinfarction can account for de novo lobar CMBs. Methods: A total of 101 patients who underwent ablation therapy for AF were prospectively registered, and 72 patients completed the assessment with MRI 6 months after catheter ablation. Brain MRI, including diffusion-weighted imaging (DWI) and susceptibility-weighted imaging (SWI), were examined at 1–3 days (baseline) and 6 months after catheter ablation. We quantitatively evaluated the spatial and temporal distribution of embolic microinfarctions and de novo CMBs.Results: Of the 101 patients, 68 were enrolled in this study. Fifty-nine patients (86.8%) showed embolic microinfarctions on baseline DWI immediately after catheter ablation. There were 137 CMBs in SWI, and 96 CMBs were of the lobar type. Six months later, there were 208 CMBs, including 71 de novo CMBs, and 60 of 71 (84.5%) were of the lobar type. Of the 71 de novo CMBs, 56 (78.9%) corresponded exactly to the location of previous embolic microinfarctions found on baseline DWI. The platelet count was significantly lower and hematocrit/hemoglobin and Fazekas score were higher in the group with de novo CMBs than in the group without de novo CMBs. Conclusions: De novo CMBs frequently appeared after catheter ablation therapy. Our results suggest that embolic microinfarction can cause lobar CMBs.
Identity Crisis: An Integrative Re-Evaluation of Typhlatya Shrimp within the Karst Aquifer of the Yucatán Peninsula, Mexico.
Authors: Ballou Lauren , Brankovits David , Chávez-Solís Efraín M. , Gonzalez Brett C. , Rohret Shari , Salinas Alexa , Liu Arielle , Simões Nuno , Alvarez Fernando , Miglietta Maria Pia , Iliffe Thomas M. , Borda Elizabeth 
Published: September 2021

Abstract
The Yucatán Peninsula, Mexico is a carbonate platform well-known for extensive karst networks of densely stratified aquifer ecosystems. This aquifer supports diverse anchialine fauna, including species of the globally distributed atyid shrimp genus Typhlatya. Four species (T. campecheae, T. pearsei, T. dzilamensis and T. mitchelli) are endemic to the Peninsula, of which three are federally listed in Mexico. This first integrative evaluation [i.e., molecular (public and newly generated), morphological, broad geographic and type locality sampling, and environmental data] of Yucatán Typhlatya reveals considerable species identity conflict in prior phylogenetic assessments, broad species ranges and sympatry within cave systems, five genetic lineages (three known and two new to science) with the endangered T. campecheae herein classified as junior synonym of the vulnerable T. pearsei. Ancestral/divergence reconstructions support convergent evolution of a low-salinity/stenohaline ancestor of a post-Paleogene arc Yucatán+Cuba Typhlatya clade within a euryhaline/anchialine-adapted atyid clade, and secondary adaptation of the coastal-restricted euryhaline [2-37 psu] T. dzilamensis (unknown conservation status), of which the remaining four species lineages are low-salinity/stenohaline adapted found in both inland and coastal regions. This study demonstrates the need for integrative/interdisciplinary approaches when conducting biodiversity assessments in complex and poorly studied aquifers.
The Role of S100B/RAGE-Enhanced ADAM17 Activation in Endothelial Glycocalyx Shedding After Traumatic Brain Injury
Authors: Zou Zhimin , Li Li , Li Qin , Zhang Kun , Liu Chengyong , Cai Daozhang , Maegele Marc , Gu Zhengtao , Huang Qiaobing 
Published: September 2021

Abstract
Background: Traumatic brain injury (TBI) remains one of the main causes for disability and death worldwide. While the primary mechanical injury cannot be avoided, the prevention of secondary injury is the focus of TBI research. Present study aimed to elucidate the effects and mechanisms of S100B and its receptor RAGE on mediating secondary injury after TBI. Methods: This study established TBI animal model by fluid percussion injury in rats, cell model by stretch-injured in astrocytes, and endothelial injury model with conditioned medium stimulation. Pharmacological intervention was applied to interfere the activities of S100B/RAGE/ADAM17 signaling pathway, respectively. The expressions or contents of S100B, RAGE, syndecan-1 and ADAM17 in brain and serum, as well as in cultured cells and medium, were detected by western blot. The distribution of relative molecules was observed with immunofluorescence. Results: We found that TBI could activate the release of S100B, mostly from astrocytes, and S100B and RAGE could mutually regulate their expression and activation. Most importantly, present study revealed an obvious increase of syndecan-1 in rat serum or in endothelial cultured medium after injury, and a significant decrease in tissue and in cultured endothelial cells, indicating TBI-induced shedding of endothelial glycocalyx. The data further proved that the activation of S100B/RAGE signaling could promote the shedding of endothelial glycocalyx by enhancing the expression, translocation and activity of ADAM17, an important sheddase, in endothelial cells. The damage of endothelial glycocalyx consequently aggravated blood brain barrier (BBB) dysfunction and systemic vascular hyper-permeability, overall resulting in secondary brain and lung injury. Conclusions: TBI triggers the activation of S100B/RAGE signal pathway. The regulation S100B/RAGE on ADAM17 expression, translocation and activation further promotes the shedding of endothelial glycocalyx, aggravates the dysfunction of BBB, and increases the vascular permeability, leading to secondary brain and lung injury. Present study may open a new corridor for the more in-depth understanding of the molecular processes responsible for cerebral and systemic vascular barrier impairment and secondary injury after TBI.
Hepatocyte CREBZF-osteopontin axis controls fibrosis in nonalcoholic steatohepatitis
Authors: Ma Fengguang , Liu Yuxiao , Hu Zhimin , Xue Yaqian , Liu Zhengshuai , Cai Genxiang , Su Weitong , Zheng Zengpeng , Ding Dong , Sun Xiaoyang , Jiang Yang , Wei Shuang , Li Wenjing , Xu Yong , Xiao Dongguang , Zhang Cuiying , Gao Xin , Dai Xiaozhen , Li Yu , Cui Aoyuan 
Published: September 2021

Abstract
Nonalcoholic steatohepatitis (NASH) has emerged as a leading cause of chronic liver disease. The incomplete understanding of NASH fibrosis limits pharmacotherapy development. Here we report a molecular link between hepatocytes and hepatic stellate cells (HSCs) in regulating the progression of liver fibrosis via CREBZF-osteopontin (OPN) axis. Hepatocyte-specific CREBZF knockout (CREBZF LKO) mice and their wild-type littermates were divided into groups that were placed on AMLN, MCD or chow diet. Mouse primary hepatocytes were treated with 250 μM PA and 10 ng/ml TNFα, the conditioned medium was collected and then transferred to HSC-T6 cells for 24 hours. Adeno-associated virus-mediated overexpression of OPN or CREBZF was performed in mice via tail vail injection. Human studies have shown that deregulation of CREBZF is associated with pathogenesis of hepatic steatosis and dyslipidemia. Here, we show that CREBZF is markedly elevated in livers of NASH mice, whereas hepatocyte-specific CREBZF knockout mice are prevented from AMLN or MCD diet-induced hepatic inflammation, liver injury and fibrosis. In vivo and in vitro mechanistic studies revealed that a key mechanism linking hepatocyte CREBZF to NASH fibrosis is miR-6964-3p-mediated inhibition of OPN, an extracellular matrix protein that activates fibrogenic genes in hepatic stellate cells. Moreover, the reduction of NASH phenotypes in CREBZF LKO mice was reversed by adeno-associated virus-mediated overexpression of OPN. Thus, CREBZF-OPN axis represents a previously unrecognized intrahepatic crosstalk in the liver that triggers fibrosis progression and contributes to the severity of NASH.
Plasma-Assisted Three-Dimensional Lightscribe Graphene as High Performance Supercapacitors
Authors: Namdar Naser , Ghasemi Foad , Sanaee Zeinab 
Published: September 2021

Abstract
Graphene-based supercapacitors demonstrate extraordinary energy storage capacity due to their layered structure, large effective surface area, high electrical conductivity and acceptable chemical stability. Herein, reduced graphene oxide (rGO)-based supercapacitors were introduced in a simple, green, fast and inexpensive method. For this purpose, graphene oxide (GO) was synthesized by the modified Hummers’ method and then easily reduced to desired patterns of rGO using a commercial LightScribe DVD drive. In order to increase the effective surface area, as well as the electrical conductivity of rGO layers, oxygen/sulfur hexafluoride plasma was applied to the rGO followed by laser irradiation. By performing such sequential processes, an rGO-based supercapacitor was introduced with a capacitance of about 10.2 F/cm3, which had high stability for more than 1000 consecutive charge-discharge cycles. The fabrication steps of the electrodes were investigated by different analyses such as SEM, TEM, Raman, surface resistance and XPS measurements. Results show that these rGO-based electrodes fabricated by sequential processes are very interesting for practical applications of energy storage.
Effect of Age on Primary Balloon Dacryocystoplasty and Probing Success in Congenital Nasolacrimal Duct Obstruction
Authors: Dericioğlu Volkan , Sevik Mehmet Orkun , Saçu Sena Sümmen , Eraslan Muhsin , Cerman Eren 
Published: September 2021

Abstract
Purpose: To compare the success rates of balloon dacryocystoplasty (BDP) and probing as a primary procedure in congenital nasolacrimal duct obstruction (CNLDO) and investigate the effect of age on both procedures.Methods: A total of 135 patients (171 eyes) with simple or incomplete complex CNLDO were included in this retrospective study; complete complex CNLDO cases were excluded. The success rates for primary BDP (118 eyes) and for probing (53 eyes) were compared as overall and among the age groups; Group 1 (12–24 months old), Group 2 (25–36 months old), and Group 3 (> 36 months old).Results: Mean age of the patients was 41.5±27.2 months for primary BDP, and 21.8±10.8 months for probing (p<0.001). Overall success rates for primary BDP and probing were 81.1% (43/53) and 76.3% (90/118), respectively (p=0.481). Success rates for BDP and probing among age groups were, 93.8% and 85.3% in Group 1 (p=0.306), 93.3% and 50.0% in Group 2 (p=0.012), and 63.6% and 27.3% in Group 3 (p=0.052), respectively. Cox regression analysis showed that the median ages were 18 months for probing and 36 months for primary BDP. Poisson regression model showed that, for every one-month increase in patients’ age, the success rate of probing decreased by 9.7%.Conclusion: Probing success decreased to a point where different treatment options such as primary BDP can be discussed with the patient’s parents after 18 months of age. The success of BDP decreased after 36 months, while it maintained a high success rate between 24-36 months as primary treatment.
Exploring Drug Cost and Disease Outcome in Rheumatoid Arthritis Patients Treated With Biologic and Targeted Synthetic DMARDs in Norway in 2010-2019 – a Country With a National Tender System for Prescription of Costly Drugs
Authors: Brkic Alen , Diamantopoulos Andreas P , Haavardsholm Espen Andre , Fevang Bjørg Tilde Svanes , Brekke Lene Kristin , Loli Liz , Zettel Camilla , Rødevand Erik , Bakland Gunnstein , Mielnik Pawel , Haugeberg Glenn 
Published: September 2021

Abstract
BACKGROUND: In Norway, an annual tender system for the prescription of biologic and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) has been used since 2007. This study aimed to explore annual b/tsDMARDs costs and disease outcomes in Norwegian rheumatoid arthritis (RA) patients between 2010 and 2019 under the influence of the tender system.METHODS: RA patients monitored in ordinary clinical practice were recruited from ten Norwegian centers. Data files from each center for each year were collected to explore demographics, disease outcomes, and the prescribed treatment. The cost of b/tsDMARDs was calculated based on the drug price given in the annual tender process.RESULTS: The number of registered RA patients increased from 4909 in 2010 to 9335 in 2019. The percentage of patients receiving a b/tsDMARD was 39.4% in 2010 and 44.5% in 2019. The proportion of b/tsDMARDs treated patients achieving DAS28 remission increased from 34.8% to 61.3%. The estimated mean annual cost to treat a patient on b/tsDMARDs fell by 47.3%, from 13,1 thousand euros (EUR) in 2010 to 6.9 thousand EUR in 2019. The mean annual cost to treat b/tsDMARDs naïve patients was reduced by 75.4% (13,0 thousand EUR in 2010 and 3.2 thousand EUR in 2019).CONCLUSIONS: In the period 2010-2019, b/tsDMARD treatment costs for Norwegian RA patients were significantly reduced, whereas DAS28 remission rates increased. Our data may indicate that the health authorities’ intention to reduce treatment costs by implementing a tender system has been successful.
Vision-related Quality of Life in Patients With Glaucoma: the Role of Illness Perceptions
Authors: Zhang Qiqi , Zhou Wenzhe , Song Di , Xie Yanqian , Lin Hao , Liang Youping , Ren Yanhan , Liang Yuanbo , Chen Yanyan 
Published: September 2021

Abstract
Purpose: To explore the predictive effect of illness perceptions on vision-related quality of life (VRQoL) in Chinese glaucoma patients.Methods: In this cross-sectional study, 97 patients with glaucoma completed the Brief Illness Perception Questionnaire (BIPQ), the Glaucoma Quality of Life-15 (GQL-15), and a questionnaire with sociodemographic and clinical information. Correlation analysis and hierarchical linear regression analysis were performed.Results: The BIPQ total score was positively correlated with the scores of the total GQL-15 and its four dimensions. Chronic comorbidities, type of glaucoma, best-corrected visual acuity (BCVA), mean defect (MD) of visual field in the better eye, and identity in the BIPQ were the critical predictors of VRQoL. Illness perceptions independently accounted for 7.8% of the variance in the VRQoL of glaucoma patients.Conclusions: Patients with stronger illness perceptions who perceive themselves as having more glaucoma symptoms are likely to experience worse VRQoL. Illness perceptions in glaucoma patients deserve clinical attention, and further studies are needed to examine whether cognitive interventions targeting illness perceptions can improve VRQoL.
Spatial-Temporal Distribution and Key Drivers of Inequalities in the Gap Between Health-Adjusted Life Expectancy and Life Expectancy: Evidence from a Megacity in China, 2010-2019.
Authors: Xi Junyan , Chen Yuanyuan , Zhang Yuqin , Luo Ao , Du Zhicheng , Liang Boheng , Dong Hang , Lin Xiao , Qin Pengzhe , Hao Yuantao 
Published: September 2021

Abstract
Purpose The improvement of the quality of life (QoL) is reflected in the narrowing of the GAP between health-adjusted life expectancy (HALE) and life expectancy (LE). Less is known about the effect that the expansion of megacities may have on narrowing the gap. The purpose of this study was to disclose this potential relationship.Methods Annual life tables were constructed from identified death records and population counts from multiple administrative sources in Guangzhou, China, 2010-2019. Joinpoint regression was used for evaluating the time trends and global Moran’s Ⅰ and local Moran’s Ⅰ was used for evaluating spatial autocorrelation at the county-level during the entire study period. Generalized principal component analysis and multilevel models were used to examine the county-level association between the GAP and socioeconomic, health services, population structure, and population dynamics.Results From 2010 to 2019, LE increased by 2.8 years (2.8 years for males and 2.9 years for females) and total HALE increased by 2.4 years (2.5 years for males and 2.2 years for females). The counties with higher or lower LE, HALE, and their GAP were presented spatial agglomeration distribution characteristics. The central city and the neighboring counties had higher LE and HALE, and lower GAP. The ratio of male to female and the natural population growth rate were positively correlated with the GAP, while the gross domestic product per area, the density of resident population, the number of practicing (assistant) physicians per thousand, the number of hospital beds per thousand, the per capita disposable income, the ratio of child to old people, the net migration rate and the total migration rate were negatively correlated with the GAP.Conclusion In megacities, LE and HALE were higher and their GAP was lower in the central city than in the urban fringe. Socio-economic and health services were key to narrow the GAP. The widening GAP can be explained by a high proportion of females and old people, who were longevity but unhealthy. Population density within the urban carrying capacity produced a positive effect on narrow the GAP, and these were attributed to the healthy immigrant effect.
A Zn(II)-Organic Framework as a Fluorescent Probe for the Aqueous Phase Detection of Nitroaromatic Explosive and Cr(III) ion
Authors: Kamal Samrah , Khalid Mohd , Khan M. Shahnawaz , Shahid M. , Ahmad Musheer 
Published: September 2021

Abstract
From the perspective of environment, civilian safety and human health it is utmost important to selectively and sensitively detect hazardous substances in the running water. In the last few decades, metal organic frameworks (MOFs) have been utilized for the detection of lethal substances in the aqueous phase using fluorescence method. Herein, a highly fluorescent MOF, Zn-MOF-1, namely, {[Zn2(pydc)2(DMF)]·2DMF}n, based on the ligand pyridine-2,5-dicarboxylic acid (H2pydc), was synthesized by employing solvothermal conditions. The Zn-MOF-1 was thoroughly characterized by crystallographic, PXRD, elemental, FTIR, and TG analysis. Single crystal data elucidated the exact structure of Zn-MOF-1. Due to its better emission spectra, the fluorescence sensing behavior of Zn-MOF-1 was checked in the aqueous medium. It was found that Zn-MOF-1 could detect Cr3+ with high sensitivity and selectivity and serve as an excellent fluorescent probe for TNP among other interfering nitroaromatic compounds in aqueous media. Furthermore, a plausible sensing mechanism has been demonstrated employing UV-Visible, fluorescence, and theoretical data. The observed Ksv values for TNP and Cr3+ are 2.1×108 M-1 and 1.46×107 M-1, respectively. Selective fluorescence quenching with high Ksv values and low detection limits validates the superior sensing performance shown by Zn-MOF-1 toward TNP and Cr3+. Thus, the fine-tuning of MOF for the detection of hazardous substances in wastewater is a challenging task and needs to address in future endeavors.
Numerical Simulation of Foundation Pit Dewatering Using Horizontal Seepage Reducing Body
Authors: Wang Jianxiu , Long Yanxia , Zhao Yu , Pan Weiqiang , Qu Jianxun , Wang Hanmei , Shi Yujin , Liu Xiaotian 
Published: September 2021

Abstract
Groundwater level has to be lowered during deep excavation. A vertical curtain is usually adopted to control the drawdown both inside and outside a foundation pit in a built-up area. However, the cost and working difficulty increases substantially with the increasing depth of vertical curtains. In the manuscript, a kind of man-made horizontal seepage reducing body (HSRB) was introduced to shorten the vertical curtain depth and control drawdown. With the No. 4 shaft foundation pit of Guangyuan Project, Shanghai as background, HSRB was proposed in foundation pit dewatering. Microbially induced carbonate precipitation grouting technology was recommended to form an environment-friendly HSRB. Numerical method was used to simulate and understand the influence of position, thickness, and hydraulic conductivity of HSRB on groundwater level. The non-separated HSRB was better than the separate HSRB. Decreasing HSRB hydraulic conductivity was better than increasing HSRB depth. Four seepage modes are summarized considering vertical curtain penetration conditions into multi-aquifer, and the fifth seepage mode was formed for vertical curtain using man-made HSRB, which can be referred by similar engineering.
AuCu nanofibers for electrosynthesis of urea from carbon dioxide and nitrite
Authors: Liu Songliang , Yin Shuli , Wang Ziqiang , Xu You , Li Xiaonian , Wang Liang , Wang Hongjing 
Published: September 2021

Abstract

Carbon dioxide reduction reaction (CO2RR) is a promising technology for mitigating greenhouse gas emission and achieving carbon neutrality. However, coupling CO2RR with other reactions to produce high value-added chemicals remains a challenge. In this work, we report self-assembled nanofibers composed of ultra-thin AuCu alloy nanowires possessing a Boerdijk-Coxeter structure with (111)-dominant facets for the electrosynthesis of urea by coupling CO2RR with nitrite reduction reaction (NO2−RR). The rich structural defects and AuCu bimetallic alloy composition provide a large number of highly catalytically active sites. The constructed AuCu nanofibers display excellent urea synthesis performance in the electrolyte solution containing 0.01 M KNO2 with continuous drumming of CO2, achieving a high urea yield rate of up to 3889.6 µg h− 1 mg− 1cat. and a high Faraday efficiency of 24.7% at -0.9 V. This work provides a feasible method for the rational design of self-assembled bimetallic nanofibers for electrosynthesis of urea under ambient conditions.