bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patients With Uncomplicated Coronavirus Disease 2019 (COVID-19) Have Long-Term Persistent Symptoms and Functional Impairment Similar to Patients with Severe COVID-19: A Cautionary Tale During a Global Pandemic
Authors: Jacobson Karen B , Rao Mallika , Bonilla Hector , Subramanian Aruna , Hack Isabelle , Madrigal Martina , Singh Upinder , Jagannathan Prasanna , Grant Philip 
Published: February 2021

Abstract
To assess the prevalence of persistent functional impairment after coronavirus disease (COVID-19), we assessed 118 individuals 3–4 months after their initial COVID-19 diagnosis with a symptom survey, work productivity and activity index questionnaire, and 6-minute walk test. We found significant persistent symptoms and functional impairment, even in non-hospitalized patients with COVID-19.
The writing and reception of Risk, Uncertainty and Profit
Authors: Emmett Ross B 
Published: February 2021

Abstract
Risk, Uncertainty and Profit was published in 1921, but started as the doctoral thesis ‘A Theory of Business Profit,’ defended in 1916. The first half of the paper examines the changes in organization and argument that Knight undertook between completing the thesis defense and the book’s publication five years later. The reorganization helped Knight focus attention on uncertainty as the most important aspect of economic life standing between the worlds of perfect and imperfect competition, and to explore more of its implications for both price theory and entrepreneurial judgment. The second half of the paper carries the story forward by examining the reception Risk, Uncertainty and Profit received from 1921 until Knight’s retirement in the early 1950s. The study of its reception uses a database of citations of Knight’s book in economics journals found through a JSTOR search. While Knight’s book is remembered today mostly for its introduction of uncertainty, in the economics literature the book’s treatment of basic price theory is more frequently cited, especially in the leading economics journals of the interwar period. The citation data indicates that the role of Risk, Uncertainty and Profit in economics education at the London School of Economics and the University of Chicago extended and expanded the book’s impact.
Instrument-based estimation with binarised treatments: issues and tests for the exclusion restriction
Authors: Andresen Martin E , Huber Martin 
Published: February 2021

Summary
When estimating local average and marginal treatment effects using instrumental variables (IVs), multivalued endogenous treatments are frequently converted to binary measures, supposedly to improve interpretability or policy relevance. Such binarisation introduces a violation of the IV exclusion if (a) the IV affects the multivalued treatment within support areas below and/or above the threshold and (b) such IV-induced changes in the multivalued treatment affect the outcome. We discuss assumptions that satisfy the IV exclusion restriction with a binarised treatment and permit identifying the average effect of (a) the binarised treatment and (b) unit-level increases in the original multivalued treatment among specific compliers. We derive testable implications of these assumptions and propose tests which we apply to the estimation of the returns to college graduation instrumented by college proximity.
Psychological Effects of Poverty on Time Preferences
Authors: Bartoš Vojtěch , Bauer Michal , Chytilová Julie , Levely Ian 
Published: February 2021

Abstract
We test whether an environment of poverty affects time preferences through purely psychological channels. We measured discount rates among farmers in Uganda who made decisions about when to enjoy entertainment instead of working. To circumvent the role of economic constraints, we experimentally induced thoughts about poverty-related problems, using priming techniques. We find that thinking about poverty increases the preference to consume entertainment early and to delay work. Using monitoring tools similar to eye tracking, a novel feature for this subject pool, we show that this effect is unlikely to be driven by less careful decision-making processes.
Financial viability of a fully simulated transformation from even-aged to uneven-aged stand structure in forests of different ages
Authors: Vítková Lucie , Saladin Dominik , Hanewinkel Marc 
Published: February 2021

Abstract
For the first time, an economic analysis of a fully simulated forest transformation process from even-aged to uneven-aged stand structure using natural regeneration was performed using an individual tree growth simulator. A comparison to a ‘business as usual’ management approach (i.e. age-class scenario) was also made. Norway spruce (Picea abies (L.) Karst.)-dominated forests of different ages were selected for the simulation: forest at thinning stage (52 years; hereafter, ‘younger stand’) and a mature stand (95 years) to explore different starting points for the transformation.
The harvested and remaining stand volume showed only little fluctuation over the course of the simulation period in the case of the transformation (uneven-aged) scenario. The age-class scenario, on the other hand, showed peaks and drops in the timber volume.
The land expectation values at the end of transformation were higher (i = 1 or 2 per cent) or equal (i = 3 per cent) to those of the age-class scenario for the younger stand. The transformation of younger forests appears to be economically interesting (under interest rates above 2 per cent) as the early revenues of more intensive thinnings achieve an equilibrium growing stock well below the potential maximum growing stock of an even-aged stand. This suggests transformation management to be economically efficient under the given silvicultural and economic conditions. The transformation of mature stands was found to be less economically viable due to the lower holding values for the transformation (uneven-aged) scenario compared with the age-class scenario. However, the holding values of the younger stand were higher for all interest rates compared with the age-class scenario.
This study concludes that transformation (uneven-aged) scenario yielded more economically viable silvicultural approach (in the case of younger forests) and a steadier trend in harvested and remaining timber volume showing no major fluctuations. Transformation approach also forms a better foundation where other ecosystem services can be built.
Comparative Genomics Suggests a Taxonomic Revision of the Staphylococcus cohnii Species Complex
Authors: Lavecchia Anna , Chiara Matteo , De Virgilio Caterina , Manzari Caterina , Pazzani Carlo , Horner David , Pesole Graziano , Placido Antonio 
Published: February 2021

Abstract
Staphylococcus cohnii (SC), a coagulase-negative bacterium, was first isolated in 1975 from human skin. Early phenotypic analyses led to the delineation of two subspecies (subsp.), Staphylococcus cohnii subsp. cohnii (SCC) and Staphylococcus cohnii subsp. urealyticus (SCU). SCC was considered to be specific to humans, whereas SCU apparently demonstrated a wider host range, from lower primates to humans. The type strains ATCC 29974 and ATCC 49330 have been designated for SCC and SCU, respectively. Comparative analysis of 66 complete genome sequences—including a novel SC isolate—revealed unexpected patterns within the SC complex, both in terms of genomic sequence identity and gene content, highlighting the presence of 3 phylogenetically distinct groups. Based on our observations, and on the current guidelines for taxonomic classification for bacterial species, we propose a revision of the SC species complex. We suggest that SCC and SCU should be regarded as two distinct species: SC and SU (Staphylococcus urealyticus), and that two distinct subspecies, SCC and SCB (SC subsp. barensis, represented by the novel strain isolated in Bari) should be recognized within SC. Furthermore, since large-scale comparative genomics studies recurrently suggest inconsistencies or conflicts in taxonomic assignments of bacterial species, we believe that the approach proposed here might be considered for more general application.
Re-induction With Intravenous Ustekinumab in Patients With Crohn’s Disease and a Loss of Response to This Therapy
Authors: Bermejo Fernando , Jiménez Laura , Algaba Alicia , Vela Milagros , Bastida Guillermo , Merino Olga , López-García Alicia , Melcarne Luigi , Rodríguez-Lago Iago , de la Maza Saioa , Bouhmidi Abdel , Barreiro-de Acosta Manuel , López-Serrano Pilar , Carrillo-Palau Marta , Mesonero Francisco , Orts Beatriz , Bonillo Daniel , Granja Alicia , Guerra Iván 
Published: February 2021

Abstract

Background
A significant percentage of patients treated with ustekinumab may lose response. Our aim was to evaluate the short-term efficacy and safety of intravenous re-induction with ustekinumab in patients with Crohn’s disease who have lost the response to the treatment.

Methods
This is a retrospective, observational, multicenter study. Treatment efficacy was measured at week 8 and 16; clinical remission was defined when the Harvey-Bradshaw Index was ≤4 points, and clinical response was defined as a decrease of ≥3 points in the index compared with the baseline. Adverse events and treatment decisions after re-induction were also collected.

Results
Fifty-three patients from 13 centers were included. Forty-nine percent had previously failed to respond to 2 biological treatments, and 24.5% had failed to respond to 3. The average exposure time to ustekinumab before re-induction was 17.7 ± 12.8 months. In 56.6% of patients, the administration interval had been shortened to every 4 to 6 weeks before re-induction. At week 8 and 16 after re-induction, 49.0% (n = 26) and 43.3% (n = 23), respectively, were in remission, whereas 64.1% (n = 34) and 52.8% (n = 28) had a clinical response. Patients who achieved remission at week 16 had lower C-reactive protein levels than those who did not respond (2.8 ± 1.6 vs 12.5 ± 9.5 mg/dL; P = 0.001). No serious adverse events related to re-induction were observed.

Conclusion
Intravenous re-induction with ustekinumab is an effective and safe strategy that recovers the response in approximately half of the patients with refractory Crohn’s disease who experience a loss of response. Re-induction can be attempted before switching out of the therapy class.
What Is the Monumental?
Authors: Shapshay Sandra 
Published: February 2021

AbstractThe aesthetic category of the sublime has been theorized (especially in the Kantian tradition) as integrally intertwined with the moral. Paradigmatic experiences of the sublime, such as gazing up at the starry night sky, or out at a storm-whipped sea, lead in a moral or religious direction depending on the cognitive stock brought to the experience, since they typically involve a feeling of awe and reflection on the peculiar situation of the human being in nature. The monumental is a similar aesthetic category, integrally intertwined with the political, but, by contrast, has garnered almost no attention from aestheticians. My main goal in this paper is to sketch a theory of ‘the monumental’ as an aesthetic category—one that is a species of the sublime but differs qualitatively from the natural/environmental sublime in significant ways, and thus merits a distinctive label. In doing so, I aim to shed light on the nature and power of monuments specifically, and to begin to address a lacuna in our understanding of a long-standing and culturally important form of public art.
A novel particle swarm optimization-based grey model for the prediction of warehouse performance
Authors: Islam Md Rakibul , Ali Syed Mithun , Fathollahi-Fard Amir Mohammad , Kabir Golam 
Published: February 2021

Abstract
Warehouses constitute a key component of supply chain networks. An improvement to the operational efficiency and the productivity of warehouses is crucial for supply chain practitioners and industrial managers. Overall warehouse efficiency largely depends on synergic performance. The managers preemptively estimate the overall warehouse performance (OWP), which requires an accurate prediction of a warehouse’s key performance indicators (KPIs). This research aims to predict the KPIs of a ready-made garment (RMG) warehouse in Bangladesh with a low forecasting error in order to precisely measure OWP. Incorporating advice from experts, conducting a literature review, and accepting the limitations of data availability, this study identifies 13 KPIs. The traditional grey method (GM)—the GM (1, 1) model—is established to estimate the grey data with limited historical information but not absolute. To reduce the limitations of GM (1, 1), this paper introduces a novel particle swarm optimization (PSO)-based grey model—PSOGM (1, 1)—to predict the warehouse’s KPIs with less forecasting error. This study also uses the genetic algorithm (GA)-based grey model—GAGM (1, 1)—the discrete grey model—DGM (1, 1)—to assess the performance of the proposed model in terms of the mean absolute percentage error and other assessment metrics. The proposed model outperforms the existing grey models in projecting OWP through the forecasting of KPIs over a 5-month period. To find out the optimal parameters of the PSO and GA algorithms before combining them with the grey model, this study adopts the Taguchi design method. Finally, this study aims to help warehouse professionals make quick OWP estimations in advance to take control measures regarding warehouse productivity and efficiency.
Comparison of Fluctuating Thermal Regimes and Commercially Achievable Constant-Temperature Regimes for Short-Term Storage of the Alfalfa Leafcutting Bee (Hymenoptera: Megachilidae)
Authors: Yocum George D , Rajamohan Arun , Rinehart Joseph P 
Published: February 2021

Abstract
Interrupting the spring incubation of Megachile rotundata (F.) with a period of low-temperature storage for synchronizing the bees’ emergence with crop bloom is an essential part of M. rotundata management. Previously, we demonstrated that bees exposed to thermoperiods (TPs) during low-temperature storage have higher survival rates than bees exposed to constant temperatures. But changing the temperature in the large mass of bees commonly found in most commercial settings would place considerable stress on the chambers’ refrigeration system. Reducing the difference between a TP’s cryophase and thermophase would decrease the stress on the refrigeration system. Therefore, we investigated a range of TPs with cryophases (12 h) of 6, 12, or 15°C and thermophases (12 h) of 15 or 18°C and compared the survival rates of these bees against bees exposed to constant temperatures of 12, 15, or 18°C. For eye-pigmented pupae, the TP 6–18°C and the control fluctuating thermal regime (FTR; 6°C with a daily 1-h pulse at 20°C) had the highest survival rates for the 2 yr tested. For the constant-temperature storage protocols, constant 15 and 18°C were either equivalent or lower survival than the control FTR. For emergence-ready adults, the 6–18°C TP had the highest survival rates. The constant 15°C and the control FTR had equivalent survival rates. Under the current constraints imposed by a commercial chamber’s refrigeration system, interrupting M. rotundata spring incubation by exposing the developing bees to constant temperatures of 15–18°C is currently the best option for commercial operations.
The Economic Rationality of Religious-Based Medical Abstinence in the Early Twentieth Century: The Case of Philadelphia’s Faith Tabernacle Congregation
Authors: Mohr Adam 
Published: February 2021

Abstract
At the turn of the twentieth century, Faith Tabernacle Congregation’s commitment to medical abstinence was an economically rational practice. To the working poor of Philadelphia, who constituted the earliest members, Faith Tabernacle’s therapy was financially attainable, psychologically supportive, and physically rejuvenating. Orthodox medicine was deficient in these three areas based on the patient narratives (i.e., testimonies) published in the church's monthly periodical Sword of the Spirit and testimony book Words of Healing. First, some early members spent all their money on orthodox medical care without relief causing significant financial hardship, while others found medical care prohibitive. Second, many early members experienced a great loss of hope because orthodox physicians ended treatment due to chronic or critical illness, both of which were interpreted as psychologically harmful. Third, early members of the church perceived getting physically worse by physicians because of low quality care, which was compounded by low access to orthodox medicine. Faith Tabernacle alternatively provided care that – in the patient narratives of the earliest members – helped them improve and get back to work faster.
Environmental and Human Rights Counterclaims in International Investment Arbitration: at the Crossroads of Domestic and International Law
Authors: Shao Xuan 
Published: February 2021

ABSTRACT
Recently, environmental and human rights (EHR) counterclaims in investment arbitration have attracted much attention as a vehicle to recalibrate the investor–state relationship. However, until now, successful instances of EHR counterclaims have been admittedly rare. As explained in this paper, some of the major barriers to EHR counterclaims in investment arbitration, and some of the concerns associated with them, are rooted in the domestic law basis of such counterclaims. Contrary to the position of several commentators, this paper argues that the grounding of EHR counterclaims on international law is neither practical nor beneficial, and EHR counterclaims are necessarily based on domestic law. Therefore, when investment arbitral tribunals adjudicate EHR counterclaims, they essentially act as an alternative to domestic courts. This has several implications. First, on questions of jurisdiction and admissibility of EHR counterclaims, decisions of states and arbitral tribunals essentially turn on the pros and cons of having these claims adjudicated by investment arbitral tribunals as opposed to domestic courts. Second, weaknesses in domestic rules, including the difficulty of holding shareholders accountable, would carry over to EHR counterclaims. Such problems can only be efficiently tackled at the level of domestic law. Third, as revealed from the inconsistent decisions in Perenco and Burlington on the merits of the environmental counterclaims, having investment arbitral tribunals adjudicate domestic law-based EHR counterclaims may cause certain concerns. For EHR counterclaims to play a more beneficial role, decision-makers must bear in mind these factors and concerns when taking their policy choices.
Genuine use of a trade mark established where proprietor is offering second-hand or spare parts service
Authors: Scarlett Roland 
Published: February 2021

Abstract
Court of Justice of the European Union, Ferrari SpA v DU, Joined Cases C–720/18 and C–721/18, EU: C:2020:854
In Ferrari SpA v DU, the Court of Justice responded to a preliminary ruling request from the Dusseldorf Higher Court and confirmed that Ferrari could establish genuine use of its ‘Testarossa’ legacy brand across the category of goods for which it was registered, on the basis of the sale of spare parts and second-hand cars.
Underreporting of Symptomatic Adverse Events in Phase I Clinical Trials
Authors: Veitch Zachary W , Shepshelovich Daniel , Gallagher Christina , Wang Lisa , Abdul Razak Albiruni R , Spreafico Anna , Bedard Philippe L , Siu Lillian L , Minasian Lori , Hansen Aaron R 
Published: February 2021

Abstract

Background
Clinician reporting of symptomatic adverse events (AEs) in phase I trials uses the Common Terminology Criteria for Adverse Events (CTCAE). The utility of the patient-reported outcomes (PROs) version of the CTCAE (PRO-CTCAE) in this setting is unknown. This prospective, observational study compared patient- and clinician-reported symptomatic AEs in phase I patients.

Methods
Phase I study–eligible patients at Princess Margaret were surveyed with the PRO-CTCAE full-item library (78 symptomatic AEs) at baseline (BL), mid-cycle 1, and mid-cycle 2 (C2). Patient and trial characteristics, best response, and survival data were collected. Presence or absence of patient- (PRO-CTCAE) or clinician-reported symptomatic AEs were compared (kappa) at defined timepoints and overall (BL+ mid-cycle 1 + C2).

Results
Of 292 patients approached from May 2017 to January 2019, a total of 265 (90.8%) were consented, with 243 (91.7%) evaluable and 552 PRO-CTCAE surveys (completion rate = 98.7%) included in analyses. Evaluation of overall patient-reported symptomatic AEs identified 50 PRO-CTCAE and 11 CTCAE items with 10% or greater reporting frequency. Nineteen CTCAE items were reported as 1% or less despite matched PRO-CTCAE items reporting as 10% or greater. Underreported categories included sexual health, bodily emissions, and cognition. Clinician- relative to patient-reporting frequency (ratio) demonstrated 9 symptomatic AEs with a 50-fold or more lower clinician reporting rate. Overall patient–clinician agreement for individual symptomatic AEs ranged from poor (κ = 0.00-0.19) to moderate (κ = 0.40-0.59), with discordance driven by lack of clinician reporting. Dyspnea (κ = 0.54) and peripheral neuropathy (κ = 0.63) at BL and limb edema (κ = 0.55) at C2 demonstrated the highest patient–clinician agreement.

Conclusions
Poor to moderate patient–clinician agreement for symptomatic AEs suggests clinician underreporting in phase I trials. Analyses of severity and interference PRO categories are ongoing.
Is Uganda’s Progressive Refugee Policy Equalizing the Food Security of National and Refugee Households?
Authors: Bashaasha Bernard , Emegu Rosemary Isoto , Yamashita Miyuki 
Published: February 2021

Abstract
Uganda is the largest refugee hosting country in Africa and third in the world. The country operates a progressive refugee integration and self-reliance policy whereby refugees are allowed access to land and other productive resources. The effectiveness of this unique approach to refugee integration has not been empirically investigated. We estimate a multinomial logistic regression model to investigate whether the food security of refugee households is not significantly different from that of Ugandan nationals. We use cross sectional data collected in July 2019 from 2400 national and refugee households across 10 control and 10 World Food Program (WFP) intervention districts in Uganda using a randomized control trial (RCT) design. As we hypothesized, Ugandan citizenship together with size of land holding, livestock ownership and consumption of animal source food, marital status and geographical location enhance the food security of the household. However, our study found surprisingly that households currently receiving WFP support remain food insecure compared to those not receiving support, something we did not anticipate finding. Another surprising finding was that women headed households were more food secure than male-headed households across other socioeconomic parameters. Our findings hence suggest that in terms of equalizing the food security of refugees with that of Ugandan nationals, Uganda’s progressive policy on refugees remains work in progress.