bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rondonin: antimicrobial properties and mechanism of action
Authors: Riciluca Katie C. T. , Oliveira Ursula C. , Mendonça Ronaldo Z. , Bozelli Junior José C. , Schreier Shirley , da Silva Junior Pedro I. 
Published: July 2021

Infectious diseases are among the major causes of death in the human population. A wide variety of organisms produce antimicrobial peptides (AMPs) as part of their first line of defense. A peptide from Acanthoscurria rondoniae plasma, rondonin—with antifungal activity, a molecular mass of 1236 Da and primary sequence IIIQYEGHKH—was previously studied (UniProt accession number B3EWP8). It showed identity with the C terminus of subunit ‘D’ of the hemocyanin of the Aphonopelma hentzi spider. This result led us to propose a new pathway of the immune system of arachnids that suggests a new function to hemocyanin: production of antimicrobial peptides. Rondonin does not interact with model membranes and was able to bind to yeast nucleic acids but not bacteria. It was not cytotoxic against mammalian cells. The antifungal activity of rondonin is pH‐dependent and peaks at pH ˜ 4–5. The peptide presents synergism with gomesin (spider hemocyte antimicrobial peptide—UniProtKB—P82358) against human yeast pathogens, suggesting a new potential alternative treatment option. Antiviral activity was detected against RNA viruses, measles, H1N1, and encephalomyocarditis. This is the first report of an arthropod hemocyanin fragment with activity against human viruses. Currently, it is vital to invest in the search for natural and synthetic antimicrobial compounds that, above all, present alternative mechanisms of action to first‐choice antimicrobials.
Appendicular Lean Mass, Grip Strength, and the Development of Knee Osteoarthritis and Knee Pain Among Older Adults
Authors: Andrews James S. , Gold Laura S. , Nevitt Michael , Heagerty Patrick J. , Cawthon Peggy M. 
Published: July 2021

ObjectiveThe association of sarcopenia with development of knee osteoarthritis (OA) or knee pain in older adults is uncertain. We examined the relationship of grip strength and appendicular lean mass (ALM) with the likelihood of developing knee OA and knee pain in older adults in the Health ABC (Health, Aging, and Body Composition) Study.MethodsALM and grip strength were assessed at baseline by dual‐energy x‐ray absorptiometry and handheld dynamometry, respectively. Incident clinically diagnosed, symptomatic knee OA, defined as new participant report of physician‐diagnosed knee OA and concurrent frequent knee pain, and incident frequent knee pain over 5 years of follow‐up were examined. Separate regression analyses, stratified by sex, modeled associations of baseline ALM and grip strength with the likelihood of incident clinically diagnosed, symptomatic knee OA and incident knee pain over follow‐up, adjusting for covariates.ResultsAmong the 2779 subjects without OA at baseline, 95 men (6.9%) and 158 women (11.3%) developed clinically diagnosed, symptomatic knee OA, and, among the 2182 subjects without knee pain at baseline, 315 men (28.3%) and 385 women (36.1%) developed knee pain over follow‐up. Among men only, each SD decrement of ALM was associated with decreasing likelihood of incident knee OA (odds ratio [OR] per SD decrement: 0.68; 95% confidence interval [CI]: 0.47‐0.97), and each SD decrement of grip strength was associated with increasing likelihood of incident knee pain (OR per SD decrement: 1.20; 95% CI: 1.01‐1.42).ConclusionIn older men, ALM and grip strength may be associated with the development of knee OA and knee pain, respectively.
Biodegradable Elastic Sponge from Nanofibrous Biphasic Calcium Phosphate Ceramic as an Advanced Material for Regenerative Medicine
Authors: Zhang Yonggang , Li Jiaping , Soleimani Mohammad , Giacomini Francesca , Friedrich Heiner , Truckenmüller Roman , Habibovic Pamela 
Published: July 2021

AbstractBiodegradable porous calcium phosphate (CaP) ceramics are widely used as synthetic graft substitutes for bone regeneration, owing to their chemical and structural similarity to bone and associated bioactivity in terms of bone‐bonding, osteoconductive, and even osteoinductive properties. Nevertheless, the intrinsic brittleness and poor processability of porous CaP ceramics strongly impair their clinical applicability. Herein, a biphasic calcium phosphate (BCP) sponge is developed that consists of a self‐supporting network of seamlessly interwoven hydroxyapatite nanowires and β‐tricalcium phosphate nanofibers and possesses a highly interconnected porous structure with open cell geometry and ultrahigh porosity. Owing to its unique properties, the ceramic sponge can be easily processed into various shapes and dimensions, such as cylindrical scaffolds and thin, flexible membranes. Moreover, the BCP sponge can be introduced into a bone defect in a compacted or folded state from a syringe and, upon wetting, expand to its original shape, thereby filling the cavity. The nanofibrous sponge gradually degrades in vitro and rapidly mineralizes when immersed in simulated body fluid. Moreover, it adsorbs significantly more proteins than a conventional porous BCP ceramic. Finally, the nanofibrous sponge supports the attachment, proliferation, and osteogenic differentiation of human mesenchymal stromal cells comparable to the conventional porous BCP ceramic.
Silk Nanocrack Origami for Controllable Random Lasers
Authors: Dogru‐Yuksel Itir Bakis , Jeong Chanho , Park Byeonghak , Han Mertcan , Lee Ju Seung , Kim Tae‐il , Nizamoglu Sedat 
Published: July 2021

AbstractThe ancient art of Origami started to evolve as a contemporary technological method for the realization of morphologically induced and unconventional advanced functional structures. Here, directional random lasers (RLs) that are formed by folding (i.e., ori) dye‐doped natural protein silk fibroin (SF) film as paper (i.e., kami) are demonstrated. The folding stress induces parallel nanocracks that simultaneously function as diffuse reflectors and laser light outcouplers at the boundaries of the optical gain medium. Random lasing is observed after a threshold energy level of 0.8 nJ µm−2 with an in‐plane divergence‐angle of 13°. Moreover, the central laser emission wavelength is tuned from 588.7 to 602.1 nm by controlling the adjacent nanocracks distance and additional laser emission directions are introduced by further folding SF at different in‐plane angles that induce rectangular and triangular geometries. More significantly, RL is fabricated via a quick, scalable, and environmentally friendly stress‐induced nanocracking process maintaining its mechanical and optical properties even after 10,000 times of bending test. Hence, this study introduces a novel form of biocompatible, biodegradable, and large‐area protein microlasers by using an unconventional laser fabrication approach.
A Rising Star from Two Worlds: Collaboration of COFs and ILs
Authors: Zhang You , Wu Ming‐Xue , Zhou Guohui , Wang Xing‐Huo , Liu Xiaomin 
Published: July 2021

AbstractThe functional composites based on covalent organic frameworks (COFs) and ionic liquids (ILs) have stimulated increasing scientific interest owing to their complementary characteristics and cooperative activation. The tailorability and diversity of COFs and ILs render the COFs‐ILs composites with predesignable structures, extendable syntheses, and customizable functionalities. Although the COFs‐ILs composites have a promising development prospect, thus far, reviews regarding COFs‐ILs composites have not been reported. This minireview summarizes the synthetic strategies including ionothermal synthesis and solvothermal synthesis; in addition, the application performances of meritorious COFs‐ILs composites ranging from catalysis, electrochemistry, adsorption and separation, luminescence sensing, and bio‐related analysis are briefly introduced. Furthermore, this minireview briefly emphasizes the opportunities and challenges faced toward rapidly developed but embryonic COFs‐ILs composites. Altogether, it is expected that this minireview will spark the potential development of COFs‐ILs composites from fundamental synthesis to cutting‐edge applications.
Capacitive Coupling of Conducting Polymer Tattoo Electrodes with the Skin
Authors: Ferrari Laura M. , Ismailov Usein , Greco Francesco , Ismailova Esma 
Published: July 2021

AbstractTattoo electronics is one of the emerging technologies in skin compliant biosensing. The growing interest in their large application in health monitoring raises several interrogations on how these sensors interface with the skin. In this paper, the bioimpedance at the interface of the skin and ultra‐conformable tattoo electrodes made of conducting polymers are focused on. The electrochemical characteristics of these electrodes differ from traditional gelled Ag/AgCl electrodes. The modeling of equivalent circuits in different skin‐electrode configurations proposes the explanation of the biopotentials transduction mechanism. The strong agreement between the circuit model and experimental values reveals the capacitive coupling of conducting polymer tattoo electrodes where circuit's values reflect the electrodes’ and skin physical characteristics. Additional studies underline an enhanced signal stability in inter/intra‐subject evaluations using dry tattoos beneficial for broad long‐term recordings. This study provides a comprehensive explanation of the skin/tattoo electrode interface model. The understanding of this interface is essential when designing next generation wearable biomonitoring devices using imperceptible interfaces.
Tailoring Trap Density of States through Impedance Analysis for Flexible Organic Field‐Effect Transistors
Authors: Choudhury Anwesha , Gupta Ritesh Kant , Garai Rabindranath , Iyer Parameswar Krishnan 
Published: July 2021

AbstractThe selection of dielectric material impacts the dielectric/semiconductor (D/S) interface which plays a significant role in defining the device performance. Hence, investigation of the D/S interfacial defects and trap states is essential for improving the device performance and designing new semiconductor and dielectric materials for organic field effect transistors (OFET). Here, the trap density of states (DOS) at the interface is investigated by impedance spectroscopy (IS). OFETs are fabricated with three different dielectric combinations and the highest mobility is found to be 0.12 cm2 V−1 s−1. Detailed analysis of the semiconductor thin film and the D/S interface is performed by atomic force microscopy, photoluminescence, time‐resolved photoluminescence and is found consistent with the DOS analysis. This work validates that IS can be utilized as a prospective DOS analysis method for OFET applications. Finally, for evaluating the potential application of the device architecture toward developing flexible electronic circuit components, the device is fabricated on a flexible substrate and the mechanical stability is examined by subjecting the device to a strain of 2.5%. The device shows no significant degradation in operation, confirming its practical utility.
Organocatalytic Enantioselective Construction of Acyclic N,N‐Acetals via Aza‐Addition of Arylamines to Ketimines
Authors: Lin Xiao , Ge Keli , He Ningning , Chen Xuling , Li Pengfei , Dong Mingxin , Li Wenjun 
Published: July 2021

AbstractA chiral phosphoric acid catalyzed enantioselective aza‐addition of arylamines to ketimines has been developed for the construction of chiral acyclic N,N‐acetal motifs. Under the standard conditions, arylamines reacted smoothly with ketimines from isoquinoline‐1,3‐dione to afford a series of acyclic N,N‐acetals in 82–99% yield with 80–96% ee.magnified image
Diastereoselective Synthesis of oxa‐Bridged Tetracyclic Benzooxazines from the Reaction of 2‐Isocyanophenyloxyacrylates and Propargylic Esters
Authors: Xiao Yao , Shen Jie , Wang Li , Lu Shanya , Li Jian 
Published: July 2021

AbstractA cascade annulation of 2‐isocyanophenyloxyacrylate and propargylic ester under basic conditions has been disclosed. This methodology enables diastereoselective synthesis of oxa‐bridged tetracyclic benzooxazine. The annulation proceeds through isomerization, Michael addition, triple annulation and acyl migration processes.magnified image
Preventing Electrolyte Decomposition on a Ca Metal Electrode Interface Using an Artificial Solid‐Electrolyte Interphase
Authors: Young Joshua , Smeu Manuel 
Published: July 2021

AbstractCalcium ion batteries are gaining attention as alternatives to lithium‐ion technology because they offer comparable properties at reduced cost and improved safety. However, progress has been limited because of the inability to efficiently and reversibly plate and strip Ca metal anodes in organic electrolytes. Moreover, the inorganic components of the solid‐electrolyte interphase (SEI) that form via decomposition of the electrolyte often do not allow for the diffusion of Ca ions. In this work, an approach combining density functional theory and ab initio molecular dynamics (AIMD) simulations is utilized to show that the use of a preformed artificial SEI layer of amorphous can potentially prevent electrolyte decomposition. First, Ca is shown to be able to intercalate into an amorphous layer (up to Ca1.5Al2O3) and diffuse through on a reasonable time scale. Through calculation of the density of states, the system is found to remain insulating up to the equilibrium stoichiometry. Finally, AIMD simulations with a realistic organic electrolyte environment are used to show that this calcinated layer completely prevents the decomposition of solvent molecules. This approach can provide a route to efficient rechargeable Ca ion batteries, paving the way for cheap large‐scale energy storage.
The treatment of hairy cell leukemia with a focus on long lasting responses to cladribine: A 30‐year experience
Authors: Broccoli Alessandro , Argnani Lisa , Nanni Laura , Terragna Carolina , Sabattini Elena , Gabrielli Giulia , Stefoni Vittorio , Pellegrini Cinzia , Casadei Beatrice , Morigi Alice , Lolli Ginevra , Carella Matteo , Coppola Paolo Elia , Zinzani Pier Luigi 
Published: July 2021

AbstractThe treatment of hairy cell leukemia (HCL) has considerably changed over years. Purine analogues, namely cladribine, now represent the treatment of choice. One hundred and eighty‐four patients were followed between 1986 and 2018 and treated according to era‐specific guidelines. Responses were classified by combining Consensus Resolution criteria and marrow immunohistochemistry. Patients were grouped according to the number of treatment lines they received. Patients treated first line responded in 86% of cases, with complete response (CR) in 44% of cases. Response rates remained high throughout the first four lines (84%, 81%, 79% for the second line onward, with CR in 38%, 37%, 15% of cases respectively). One hundred and twenty‐two patients received cladribine as first line treatment, with a response rate of 86% and a CR rate of 54%. Among the 66 CR patients, 45 (68%) have never received further therapy: 11 patients are in continuous CR between 5 and 10 years after treatment, 14 between 10 and 20 years and three patients at more than 20 years. Median time‐to‐next treatment (TTNT) for frontline cladribine‐treated patients was 8.2 years: partial responders had a significantly shorter median TTNT than CR patients (5.3 years vs median not reached at 25.8 years, p < 0.001). Patients with HCL require subsequent lines of therapy in more than 50% of cases. Purine analogues allow significant response rates when applied first line and upon retreatment. Some patients may enjoy long lasting treatment‐free intervals after one course of cladribine.
Lung function decline before and after treatment of World Trade Center associated obstructive airways disease with inhaled corticosteroids and long‐acting beta agonists
Authors: Goldfarb David G. , Putman Barbara , Lahousse Lies , Zeig‐Owens Rachel , Vaeth Brandon M. , Schwartz Theresa , Hall Charles B. , Prezant David J. , Weiden Michael D. 
Published: July 2021

AbstractBackgroundGreater than average loss of one‐second forced expiratory volume (FEV1) is a risk factor for asthma, chronic obstructive pulmonary disease (COPD), and asthma/COPD overlap syndrome in World Trade Center (WTC)‐exposed firefighters. Inhaled corticosteroids and long‐acting beta agonists (ICS/LABA) are used to treat obstructive airways disease but their impact on FEV1‐trajectory in this population is unknown.MethodsThe study population included WTC‐exposed male firefighters who were treated with ICS/LABA for 2 years or longer (with initiation before 2015), had at least two FEV1 measurements before ICS/LABA initiation and two FEV1 measurements posttreatment between September 11, 2001 and September 10, 2019. Linear mixed‐effects models were used to estimate FEV1‐slope pre‐ and post‐treatment.ResultsDuring follow‐up, 1023 WTC‐exposed firefighters were treated with ICS/LABA for 2 years or longer. When comparing intervals 6 years before and 6 years after treatment, participants had an 18.7 ml/year (95% confidence interval [CI]: 11.3–26.1) improvement in FEV1‐slope after adjustment for baseline FEV1, race, height, WTC exposure, weight change, blood eosinophil concentration, and smoking status. After stratification by median date of ICS/LABA initiation (January 14, 2010), earlier ICS/LABA‐initiators had a 32.5 ml/year (95% CI: 19.5–45.5) improvement in slope but later ICS/LABA‐initiators had a nonsignificant FEV1‐slope improvement (7.9 ml/year, 95% CI: −0.5 to 17.2).ConclusionsWTC‐exposed firefighters treated with ICS/LABA had improved FEV1 slope after initiation, particularly among those who started earlier. Treatment was, however, not associated with FEV1‐slope improvement if started after the median initiation date (1/14/2010), likely because onset of disease began before treatment initiation. Research on alternative treatments is needed for patients with greater than average FEV1‐decline who have not responded to ICS/LABA.
Bronchial angiofibroma in tuberous sclerosis complex: A case report and literature review
Authors: Teng Peikun , Liu Jing , Liu Deshun , Li Wenfei , Liu Xuedong 
Published: July 2021

AbstractCutaneous angiofibroma is part of the classic triad of tuberous sclerosis complex (TSC). Angiofibroma is rarely reported to affect the mucous membranes of the trachea and bronchus. Tracheobronchial angiofibroma is also a hamartomatous manifestation of TSC. Considering the paucity of literature describing tracheal lesions in TSC, more case reports are needed to guide treatment planning. This case report adds to the existing clinical literature and provides a reference for clinical diagnosis.
Somatic KRAS mutation affecting codon 146 in linear sebaceous nevus syndrome
Authors: Kapoor Saloni , Scanga Hannah L. , Reyes‐Múgica Miguel , Nischal Ken K. 
Published: July 2021

AbstractLinear Sebaceous Nevus Syndrome is a rare disorder that presents with nevus sebaceus in association with corneal dermoids, colobomas, choroidal osteomas, and arachnoid cysts. It is thought to represent a mosaic RASopathy. These are disorders characterized by postzygotic somatic mutation in genes involved in RAS/MAPK signaling pathway. In this report we describe two patients with linear sebaceous nevus syndrome found to have mutations in codon 146 of KRAS with evidence of mosaicism. This specific mutation has previously been reported in Oculoectodermal Syndrome and Encephalocraniocutaneous Lipomatosis, two other mosaic RASopathies with predominantly cerebrooculocutaneous manifestations. These findings suggest that, while initially classified as different syndromes, these disorders should be evaluated and managed as a spectrum of related disorders.
Cycloadditionen mit einer stabilen ladungsseparierten cyclobutadienartigen Siliciumringverbindung
Authors: Keuter Jan , Hepp Alexander , Daniliuc Constantin G. , Feldt Milica , Lips Felicitas 
Published: July 2021

AbstractReduktive Debromierung von {N(SiMe3)2}SiBr3 mit Rieke‐Magnesium führt zu einem 1:1‐Gemisch des fünfkernigen Siliciumclusters Si5{N(SiMe3)2}5Br, 1, mit einem Bromsubstituenten und der Cyclobutadien‐analogen Si4‐Ringverbindung 2. Verbindung 2 besitzt einen planaren rautenförmigen Si4‐Ring mit einem ladungsseparierten elektronischen Zustand. Die Siliciumatome in 2 sind alternierend trigonal‐planar und ‐pyramidal konfiguriert. In Cycloadditionen mit Ethen, Diethylacetylen, 1,5‐Cyclooctadien und 2,3‐Dimethyl‐1,3‐butadien wurden die cyclischen ungesättigten Ringverbindungen 3–6 bei Raumtemperatur in quantitativen Ausbeuten erhalten. Die Verbindungen 3 und 6 gehen photochemische Isomerisierungen mit LED‐Licht ein (λ=405 nm), wobei die gesättigten Siliciumringverbindungen 4 e und 6′ gebildet werden.
Redox‐Switchable Cycloisomerization of Alkynoic Acids with Napthalenediimide‐Derived N‐Heterocyclic Carbene Complexes
Authors: Ruiz‐Zambrana César , Gutiérrez‐Blanco Ana , Gonell Sergio , Poyatos Macarena , Peris Eduardo 
Published: July 2021

AbstractTwo naphthalene‐diimide (NDI) bis‐imidazolium salts have been used as N‐heterocyclic carbene (NHC) precursors for the preparation of NDI‐functionalized complexes of rhodium and iridium of general formula [MCl(NDI‐NHC)(COD)] (M=Rh, Ir; NDI‐NHC=NDI‐functionalized NHC ligand). Comparison of the IR spectra of the complexes [IrCl(NDI‐NHC)(CO)2] and their related one‐ and two‐electron reduced forms, reveal that each one‐electron reduction produces a decrease of the average ν(CO) of 9–10 cm−1, indicating a significant enhancement of the electron‐richness of the metal. The [MCl(NDI‐NHC)(COD)] complexes were tested in the catalytic cycloisomerization of alkynoic acids. The one‐electron reduced forms showed greatly enhanced activities. For the cyclization of 5‐hexynoic acid, the two‐electron reduction of the ligand produced further enhancement of the catalytic activity, therefore showing that the catalyst can switch between three redox species with three distinct catalytic activities.
Amino‐functionalized carbon nanotubes for effectively improving the mechanical properties of pre‐impregnated epoxy resin/carbon fiber
Authors: dos Santos Alan Silva , de Oliveira Thais Cardoso , Rodrigues Karla Faquine , Silva Amanda Alvarenga Coutinho , Coppio Gustavo José Lauer , da Silva Fonseca Beatriz Carvalho , Simonetti Evelyn Alves Nunes , Cividanes Luciana De Simone 
Published: July 2021

AbstractPre‐impregnated carbon fiber/epoxy resin (CF/epoxy prepreg) gained its popularity for significant stress applications, especially in the aerospace industry, owing to its excellent resistance and low specific mass. However, these CF/epoxy prepregs have a tendency to crack propagation. A solution for the prepregs fragility is the addition of carbon nanotubes (CNTs), especially those functionalized with amino groups, reinforcing the material due to its exceptional mechanical properties. In this work, the influence of the carbon chain length of two different amino‐functionalized CNTs from diverse backgrounds (commercial and laboratory growth CNTs) is studied. The nanofillers were added in CF/epoxy prepregs by dry spraying without solvent aid. CNTs' samples were characterized by X‐ray photoelectron spectroscopy, Raman spectroscopy, transmission electron microscopy, and thermogravimetric analysis (TGA), while the composites were analyzed by TGA, dynamic‐mechanical analysis, and field emission scanning electron microscopy. The various surface treatment occurred at different levels according to the CNTs background, and all samples exhibited a distinct behavior. These differences were also observed in the composites' thermomechanical performance: CNTs functionalized with larger carbon chain amine presented the best results, with an increase of almost 100% in the storage moduli (E'), confirming the efficiency of amino‐functionalized CNTs in the reinforcement of CF/epoxy prepregs.