bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ten Years of EWAS
Authors: Wei Siyu , Tao Junxian , Xu Jing , Chen Xingyu , Wang Zhaoyang , Zhang Nan , Zuo Lijiao , Jia Zhe , Chen Haiyan , Sun Hongmei , Yan Yubo , Zhang Mingming , Lv Hongchao , Kong Fanwu , Duan Lian , Ma Ye , Liao Mingzhi , Xu Liangde , Feng Rennan , Liu Guiyou , Project The EWAS , Jiang Yongshuai 
Published: August 2021

AbstractEpigenome‐wide association study (EWAS) has been applied to analyze DNA methylation variation in complex diseases for a decade, and epigenome as a research target has gradually become a hot topic of current studies. The DNA methylation microarrays, next‐generation, and third‐generation sequencing technologies have prepared a high‐quality platform for EWAS. Here, the progress of EWAS research is reviewed, its contributions to clinical applications, and mainly describe the achievements of four typical diseases. Finally, the challenges encountered by EWAS and make bold predictions for its future development are presented.
Low‐Intensity Focused Ultrasound‐Responsive Ferrite‐Encapsulated Nanoparticles for Atherosclerotic Plaque Neovascularization Theranostics
Authors: Yao Jianting , Yang Zhuowen , Huang Liandi , Yang Chao , Wang Jianxin , Cao Yang , Hao Lan , Zhang Liang , Zhang Jingqi , Li Pan , Wang Zhigang , Sun Yang , Ran Haitao 
Published: August 2021

AbstractPathological angiogenesis is a crucial factor that causes atherosclerotic plaque rupture. Sinoporphyrin sodium‐mediated sonodynamic therapy (DVDMS‐SDT) induces regression of plaque neovascularization in humans without causing obvious side effects. However, a clinical noninvasive theranostic strategy for atherosclerotic plaque neovascularization is urgently needed. A nanoplatform designed for multimodality imaging‐guided SDT in plaque angiogenesis theranostics, termed PFP–HMME@PLGA/MnFe2O4–ramucirumab nanoparticles (PHPMR NPs), is fabricated. It encapsulates manganese ferrite (MnFe2O4), hematoporphyrin monomethyl ether (HMME), and perfluoropentane (PFP) stabilized by polylactic acid‐glycolic acid (PLGA) shells and is conjugated to an anti‐VEGFR‐2 antibody. With excellent magnetic resonance imaging (MRI)/photoacoustic/ultrasound imaging ability, the distribution of PHPMR NPs in plaque can be observed in real time. Additionally, they actively accumulate in the mitochondria of rabbit aortic endothelial cells (RAECs), and the PHPMR NP‐mediated SDT promotes mitochondrial‐caspase apoptosis via the production of reactive oxygen species and inhibits the proliferation, migration, and tubulogenesis of RAECs. On day 3, PHPMR NP‐mediated SDT induces apoptosis in neovessel endothelial cells and improves hypoxia in the rabbit advanced plaque. On day 28, PHPMR NP‐mediated SDT reduces the density of neovessels, subsequently inhibiting intraplaque hemorrhage and inflammation and eventually stabilizing the plaque. Collectively, PHPMR NP‐mediated SDT presents a safe and effective theranostic strategy for inhibiting plaque angiogenesis.
Humanized Biomimetic Nanovesicles for Neuron Targeting
Authors: Zinger Assaf , Cvetkovic Caroline , Sushnitha Manuela , Naoi Tomoyuki , Baudo Gherardo , Anderson Morgan , Shetty Arya , Basu Nupur , Covello Jennifer , Tasciotti Ennio , Amit Moran , Xie Tongxin , Taraballi Francesca , Krencik Robert 
Published: August 2021

AbstractNanovesicles (NVs) are emerging as innovative, theranostic tools for cargo delivery. Recently, surface engineering of NVs with membrane proteins from specific cell types has been shown to improve the biocompatibility of NVs and enable the integration of functional attributes. However, this type of biomimetic approach has not yet been explored using human neural cells for applications within the nervous system. Here, this paper optimizes and validates the scalable and reproducible production of two types of neuron‐targeting NVs, each with a distinct lipid formulation backbone suited to potential therapeutic cargo, by integrating membrane proteins that are unbiasedly sourced from human pluripotent stem‐cell‐derived neurons. The results establish that both endogenous and genetically engineered cell‐derived proteins effectively transfer to NVs without disruption of their physicochemical properties. NVs with neuron‐derived membrane proteins exhibit enhanced neuronal association and uptake compared to bare NVs. Viability of 3D neural sphere cultures is not disrupted by treatment, which verifies the utility of organoid‐based approaches as NV testing platforms. Finally, these results confirm cellular association and uptake of the biomimetic humanized NVs to neurons within rodent cranial nerves. In summary, the customizable NVs reported here enable next‐generation functionalized theranostics aimed to promote neuroregeneration.
Das erste Hochdruck‐Chromoxonitridoborat CrB4O6N – ein unerwartetes Bindeglied zur Chemie der Nitridosilikate
Authors: Fuchs Birgit , Johrendt Dirk , Bayarjargal Lkhamsuren , Huppertz Hubert 
Published: August 2021

AbstractCrB4O6N kristallisiert in der nicht‐zentrosymmetrischen Raumgruppe P63mc (Nr. 186) mit den Gitterparametern a=5.1036(1), c=8.3519(3) Å und einem Volumen von 188,40(1) Å3. Synthetisiert durch ein Hochdruck‐/Hochtemperaturexperiment bei 7 GPa und 1673 K, repräsentiert die Phase das erste Hochdruck‐Oxonitridoborat. Strukturell zeigen sich sternförmige Einheiten bestehend aus vier BO3N‐Tetraedern, die in Analogie zu den homeotypen Nitridosilikaten MYbSi4N7 (M=Sr, Ba, Eu) durch ein gemeinsames vierfach koordiniertes Stickstoffatom miteinander verknüpft sind. Diese Einheiten bilden ein Netzwerk aus, in dessen Kanälen die Cr3+‐Ionen liegen. Im Gegensatz zu den trigonal‐planaren B(O/N)3‐Einheiten in allen anderen bekannten Oxonitridoboraten zeigt CrB4O6N erstmals tetraedrische Baueinheiten. Die strukturellen Zusammenhänge sowie die Ergebnisse der spektroskopischen Messungen und theoretischen Rechnungen am Chromoxonitridoborat werden im Folgenden erörtert.
Creating safe schools by building safe relationships
Authors: Eppler‐Wolff Nancy , Martin Anne 
Published: August 2021

AbstractJonathan Cohen outlines three types of goals for schools to pursue—systemic improvement goals, instructional improvement goals, and relational improvement goals—but states that it is impractical to expect schools to address all three at once. This study argues that it is in fact essential that relational improvement goals be pursued concomitantly with systemic and instructional improvement goals in order for the latter to succeed. Several foundational psychoanalytic precepts used to build the patient–therapist alliance apply well to building relationships with stakeholders within a school context, ranging from students and parents to teachers and leaders. We present our own experience implementing the School‐Based Mental Health Collaboration (SBMHC) in a handful of public elementary schools in high‐poverty neighborhoods in New York City. This program relies on classroom consultants who spend a half day a week in an assigned classroom co‐teaching a social–emotional learning (SEL) curriculum; consulting with teachers about students, classroom management, and the integration of SEL into the classroom culture; and referring children for community‐based services. SBMHC staff take a mentalizing stance of nonjudgmental curiosity about the meaning and function of stakeholders' behaviors, while encouraging stakeholders to do the same with each other. This approach builds strong relationships in which stakeholders can reflect safely and thoughtfully about their own behaviors and that of their students. We find that it is within this “holding environment” that school stakeholders are best poised to undertake the difficult attitudinal and behavioral changes necessary to promote school safety.
Red Bean Pod Derived Heterostructure Carbon Decorated with Hollow Mixed Transition Metals as a Bifunctional Catalyst in Zn‐Air Batteries
Authors: Mahbub Muhammad Adib Abdillah , Adios Celfi Gustine , Xu Michael , Prakoso Bagas , LeBeau James M. , Sumboja Afriyanti 
Published: August 2021

AbstractDesign and synthesis of low‐cost and efficient bifunctional catalysts for oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) in Zn‐air batteries are essential and challenging. We report a facile method to synthesize heterostructure carbon consisting of graphitic and amorphous carbon derived from the agricultural waste of red bean pods. The heterostructure carbon possesses a large surface area of 625.5 m2 g−1, showing ORR onset potential of 0.89 V vs. RHE and OER overpotential of 470 mV at 5 mA cm−2. Introducing hollow FeCo nanoparticles and nitrogen dopant improves the bifunctional catalytic activity of the carbon, delivering ORR onset potential of 0.93 V vs. RHE and OER overpotential of 360 mV. Electron energy‐loss spectroscopy (EELS) O K‐edge map suggests the presence of localized oxygen on the FeCo nanoparticles, suggesting the oxidation of the nanoparticles. Zn‐air battery with these carbon‐based catalysts exhibits a peak power density as high as 116.2 mW cm−2 and stable cycling performance over 210 discharge/charge cycles. This work contributes to the advancement of bifunctional oxygen electrocatalysts while converting agricultural waste into value‐added material.
Determining the optimal PD‐1/PD‐L1 inhibitors for the first‐line treatment of non‐small‐cell lung cancer with high‐level PD‐L1 expression in China
Authors: Teng Meng‐Meng , Chen Si‐Ying , Yang Bo , Wang Yan , Han Rui‐Ying , An Meng‐Na , Dong Ya‐lin , You Hai‐Sheng 
Published: August 2021

AbstractBackground and ObjectiveThe programmed death 1 and ligand (PD‐1/PD‐L1) inhibitors have significantly altered therapeutic perspectives on non‐small‐cell lung cancer (NSCLC). However, their efficacy and safety are unknown since direct clinical trials have not yet been performed on them. It is also necessary to determine the economics of PD‐1/PD‐L1 inhibitors due to their high cost. The aim was to evaluate the efficacy, safety, and cost‐effectiveness of PD‐1/PD‐L1 inhibitor monotherapy for advanced NSCLC patients in China with high PD‐L1 expression as first‐line treatment.MethodsFrom the PubMed, Cochrane, and Web of Science databases, we retrieved survival, progression, and safety data on PD‐1/PD‐L1 inhibitor monotherapy for advanced NSCLC patients. A network meta‐analysis (NMA) was performed to consider PD‐1/PD‐L1 inhibitors in efficacy and safety. A Markov model with a full‐lifetime horizon was adopted. Clinical and utility data were collected through the trial. The cost per quality‐adjusted life year (QALY) was as incremental cost‐effectiveness ratio (ICER). Sensitivity analyses were performed.ResultsThis study included five phase III clinical trials using four drugs: nivolumab, pembrolizumab, atezolizumab, and durvalumab. The NMA demonstrated that the four drugs had similar efficacy and safety, while pembrolizumab and atezolizumab were better for than for nivolumab (hazard ratio (HR) = 0.66, 95% confidence intervals (CIs): 0.46–0.95 and HR = 0.59, 95%CI: 0.37–0.94) in progression‐free survival (PFS), and the risk of a severe adverse event was higher for atezolizumab than for nivolumab and pembrolizumab. Compared with nivolumab, durvalumab, pembrolizumab, and atezolizumab had QALY of 0.19, 0.38, and 0.53, respectively, which induced ICERs of $ 197,028.8/QALY, $ 111,859.0/QALY, and $ 76,182.3/QALY, respectively.ConclusionThe efficacy and safety are similar among types of PD‐1/PD‐L1‐inhibitor monotherapy. The cost‐effectiveness of nivolumab appears optimal, but the other PD‐1/PD‐L1 inhibitors are not as cost‐effective for the first‐line treatment of advanced NSCLC in China.
Phase 1, pharmacogenomic, dose‐expansion study of pegargiminase plus pemetrexed and cisplatin in patients with ASS1‐deficient non‐squamous non‐small cell lung cancer
Authors: Szlosarek Peter W. , Wimalasingham Akhila G. , Phillips Melissa M. , Hall Peter E. , Chan Pui Ying , Conibear John , Lim Louise , Rashid Sukaina , Steele Jeremy , Wells Paula , Shiu Chiung‐Fang , Kuo Chih‐Ling , Feng Xiaoxing , Johnston Amanda , Bomalaski John , Ellis Stephen , Grantham Marianne , Sheaff Michael 
Published: August 2021

AbstractIntroductionWe evaluated the arginine‐depleting enzyme pegargiminase (ADI‐PEG20; ADI) with pemetrexed (Pem) and cisplatin (Cis) (ADIPemCis) in ASS1‐deficient non‐squamous non‐small cell lung cancer (NSCLC) via a phase 1 dose‐expansion trial with exploratory biomarker analysis.MethodsSixty‐seven chemonaïve patients with advanced non‐squamous NSCLC were screened, enrolling 21 ASS1‐deficient subjects from March 2015 to July 2017 onto weekly pegargiminase (36 mg/m2) with Pem (500 mg/m2) and Cis (75 mg/m2), every 3 weeks (four cycles maximum), with maintenance Pem or pegargiminase. Safety, pharmacodynamics, immunogenicity, and efficacy were determined; molecular biomarkers were annotated by next‐generation sequencing and PD‐L1 immunohistochemistry.ResultsADIPemCis was well‐tolerated. Plasma arginine and citrulline were differentially modulated; pegargiminase antibodies plateaued by week 10. The disease control rate was 85.7% (n = 18/21; 95% CI 63.7%–97%), with a partial response rate of 47.6% (n = 10/21; 95% CI 25.7%–70.2%). The median progression‐free and overall survivals were 4.2 (95% CI 2.9–4.8) and 7.2 (95% CI 5.1–18.4) months, respectively. Two PD‐L1‐expressing (≥1%) patients are alive following subsequent pembrolizumab immunotherapy (9.5%). Tumoral ASS1 deficiency enriched for p53 (64.7%) mutations, and numerically worse median overall survival as compared to ASS1‐proficient disease (10.2 months; n = 29). There was no apparent increase in KRAS mutations (35.3%) and PD‐L1 (<1%) expression (55.6%). Re‐expression of tumoral ASS1 was detected in one patient at progression (n = 1/3).ConclusionsADIPemCis was safe and highly active in patients with ASS1‐deficient non‐squamous NSCLC, however, survival was poor overall. ASS1 loss was co‐associated with p53 mutations. Therapies incorporating pegargiminase merit further evaluation in ASS1‐deficient and treatment‐refractory NSCLC.
Progress of the Catalytic Deactivation of H‐ZSM‐5 Zeolite in Glycerol Dehydration
Authors: Catuzo Gabriel L. , Possato Luiz G. , Sad María Eugenia , Padró Cristina , Martins Leandro 
Published: August 2021

AbstractGlycerol conversion into value‐added chemicals has received much attention due to the prospect of increasing the biodiesel industry‘s profitability. The dehydration of glycerol is one of the most explored reactions in the valorization of glycerol, and the zeolite H‐ZSM‐5 is one of the furthermost used structures. In this study, several characterization techniques were used to investigate the detailed aging of coke in spent H‐ZSM‐5 zeolites after their use in the gas‐phase glycerol dehydration to produce acrolein. The carbonaceous deposits formed almost totally in the first minutes of the reaction. They rapidly got trapped inside the pores, hampering the accessibility to active sites and the zeolite‘s full catalytic action. Two types of coke were formed during the reaction: polyglycols, on the external surface, and aromatics, inside the pores, representing the majority (∼98 wt.%) of the carbonaceous compounds. Besides, aromatic compounds age over time, becoming bulkier and more deficient in hydrogen. We also found a correlation between the amount of coke, its size, accessibility to the acid active sites, and changes in crystallographic parameters of the zeolite with the presence of coke.
Adsorption of Brilliant Blue and Malachite Green by Nano‐graphene Exfoliated from Waste Batteries
Authors: Karunanithi Bogeshwaran , Kannaiyan Sathish Kumar , Balakrishnan Karunanithi , Muralidharan Srividhya , Gopi Gowri 
Published: August 2021

AbstractWaste graphite rods from waste batteries, acting as a source of graphite, were electrochemically exfoliated to synthesize graphene. Mesoporous graphene with a pore size of 14.81 Å and a surface area of 710.396 m2g−1 was chosen for adsorptive studies involving toxic dyes, Brilliant Blue (BB) and Malachite Green (MG), by varying the graphene dosage, contact period, temperature, pH, and the concentration of the dye solution. The maximum adsorption capacities reported were 120 mg gBB−1 and 342 mg gMG−1, with dye removal rates of BB and MG greater than 99 and 98 %, respectively. Adsorption occurred as multilayer, following the Freundlich isotherm model, and the pseudo‐second‐order kinetic model fitted best, indicating chemisorption. Thermodynamic studies reveal an exothermic, spontaneous, and chemical adsorption.
One‐Pot Synthesis of Tensile‐Strained PdRuCu Icosahedra toward Electrochemical Hydrogenation of Alkene
Authors: Zhu Kaili , Xu Xudong , Xu Mengqiu , Deng Ping , Wu Wenbo , Ye Wei , Weng Zihui , Su Yue , Wang Huijie , Xiao Fei , Fang Zeping , Gao Peng 
Published: August 2021

AbstractElectrochemical hydrogenation (ECH) uses electricity to drive proton (H+) reduction for hydrogenation, which can greatly reduce energy supply and environmental pollution, representing an ideal alternative to traditional thermal hydrogenation. In this work, we put forward tensile‐strained PdRuCu alloy to promote ECH. Tensile strain promotes the adsorption of C=C by changing the d‐band center. Meanwhile, alloying Ru and Cu into Pd lattice facilitates hydrogenation by weakening Pd−H bonding. Therefore, PdRuCu icosahedra display excellent ECH performance of 2‐methyl‐3‐buten‐2‐ol (MBE) with specific activity of 227.4 μmolMBE nm−2 min−1 at −0.3 V versus reversible hydrogen electrode (RHE), about 16.1 and 10.5 times higher than that of commercial Pd/C and Ru/C, respectively. In addition, PdRuCu icosahedra was excellent in the scaling up of substrate concentration combined with anisyl alcohol oxidation to produce high‐value added anisaldehyde at anode. This work provides a guideline for the rational design of highly active and durable metallic catalyst in ECH.
Amylopectin graft copolymers for oil sands tailings treatment
Authors: Davey Stepheney , Soares João B. P. 
Published: August 2021

AbstractThe oil sands industry has contributed to the Canadian economy for over 50 years. Challenges have arisen, however, due to worldwide concerns regarding the long‐term environmental impact of waste by‐products generated in the bitumen extraction process from oil sands. Reclaiming legacy tailings and reducing the number of ponds are two of these challenges. This article describes the synthesis and characterization of amylopectin‐graft‐hydrolyzed‐poly(methyl acrylate) copolymers with different graft lengths and densities, and how they can be used to treat oil sands tailings. Flocculation and dewatering results depend strongly on how the hydrophobic amylopectin backbones are combined with the hydrophilic hydrolyzed poly(methyl acrylate) grafts. These hybrid polymers, combining a natural backbone with synthetic grafts, seem to be an attractive alternative to treat oil sands and probably other mineral ore tailings.
Catalytic Hydrogen Transfer Reactions
Authors: Zhu Shou‐Fei 
Published: August 2021

AbstractOur recently studies on three types of reactions with hydrogen transfer as a key step, including catalytic asymmetric proton transfer reactions using “chiral proton transfer shuttle”, catalytic B—H bond insertion containing a hydrogen atom transfer, and iron‐catalyzed hydrosilylation reactions containing hydride transfer were briefly introduced.
What is the most favorite and original chemistry developed in your research group?The discovery of B—H bond insertion reaction.How do you get into this specific field? Could you please share some experiences with our readers?The reaction of B—H bond insertion was a serendipitous result during we pursuing the other carbene insertion reactions. My lesson on this project is that the discovery may come from bold hypothesis, cautious verification, and appropriate evaluation on unexpected results.How do you supervise your students?Try my best to stimulate their enthusiasm for innovation, provide them strongest supports, and explore unknown with them as a partner.What is the most important personality for scientific research?Passion for self‐actualization and curiosity.How do you keep balance between research and family?Travel with my family regularly and try to share my research progresses with them.
Persistent human bocavirus 1 infection and tonsillar immune responses
Authors: Ivaska Lotta E. , Silvoniemi Antti , Palomares Oscar , Turunen Riitta , Waris Matti , Mikola Emilia , Puhakka Tuomo , Söderlund‐Venermo Maria , Akdis Mübeccel , Akdis Cezmi A. , Jartti Tuomas 
Published: August 2021

AbstractBackgroundPersistent human bocavirus 1 (HBoV1) infection is a common finding in patients suffering from chronic tonsillar disease. However, the associations between HBoV1 infection and specific immune reactions are not completely known. We aimed to compare in vivo expression of T‐cell cytokines, transcription factors, and type I/III interferons in human tonsils between HBoV1‐positive and ‐negative tonsillectomy patients.MethodsTonsil tissue samples, nasopharyngeal aspirate (NPA), and serum samples were obtained from 143 immunocompetent adult and child tonsillectomy patients. HBoV1 and 14 other respiratory viruses were detected in NPAs and tonsil tissues by polymerase chain reaction (PCR). Serology and semi‐quantitative PCR were used for diagnosing HBoV1 infections. Expression of 14 cytokines and transcription factors (IFN‐α, IFN‐β, IFN‐γ, IL‐10, IL‐13, IL‐17, IL‐28, IL‐29, IL‐37, TGF‐β, FOXP3, GATA3, RORC2, Tbet) was analyzed by quantitative reverse‐transcription (RT)‐PCR in tonsil tissues.ResultsHBoV1 was detected by PCR in NPA and tonsils from 25 (17%) study patients. Serology results indicated prior nonacute infections in 81% of cases. Tonsillar cytokine responses were affected by HBoV1 infection. The suppression of two transcription factors, RORC2 and FOXP3, was associated with HBoV1 infection (p < 0.05). Furthermore, intratonsillar HBoV1‐DNA loads correlated negatively with IFN‐λ family cytokines and IL‐13.ConclusionsOur study shows distinctively decreased T‐helper17 and T‐regulatory type immune responses in local lymphoid tissue in HBoV1‐positive tonsillectomy patients. HBoV1 may act as a suppressive immune modulator.
Luminance contrast detection is optimized for the large‐scale luminance texture of the surround
Authors: Hayasaka Misaki , Nagai Takehiro , Yamauchi Yasuki , Sato Tomoharu , Kuriki Ichiro 
Published: August 2021

AbstractContrast sensitivity functions (CSFs) have been typically measured under persistent adaptation to a uniform background. However, this is an unusual situation, considering that visual scenes in our daily lives are typically filled by objects of various luminance levels in a wide dynamic range. We investigated the interactions between the luminance range of textured adapting background and test luminance (luminance of an immediate surround) to see how the contrast sensitivities adapt to background luminance distributions. The background was a random array of one‐dimensional lines, which had a maximum luminance range of approximately 1:520 000, and the test stimulus was a Gabor patch presented on an immediate uniform surround with various luminance levels. The carrier orientation of the Gabor patch was orthogonal to that of the background lines. In the results, the sensitivity was highest near the mean of background luminance, and the luminance range with the highest sensitivity became wider (i.e., the selectivity of sensitivity optimization weakened) as the background luminance range became larger. This sensitivity optimization was significant mainly in the lower spatial frequency. These results indicate that the overall contrast sensitivity is adjusted to the luminance range of the visual scene and the sensitivity optimization is more flexible in relatively lower spatial frequency.