bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genes and hormones of the hypothalamic–pituitary–adrenal axis in post-traumatic stress disorder. What is their role in symptom expression and treatment response?
Authors: Fischer Susanne , Schumacher Tabea , Knaevelsrud Christine , Ehlert Ulrike , Schumacher Sarah 
Published: April 2021

Abstract
Background
Less than half of all individuals with post-traumatic stress disorder (PTSD) remit spontaneously and a large proportion of those seeking treatment do not respond sufficiently. This suggests that there may be subgroups of individuals who are in need of augmentative or alternative treatments. One of the most frequent pathophysiological findings in PTSD is alterations in the hypothalamic–pituitary–adrenal (HPA) axis, including enhanced negative feedback sensitivity and attenuated peripheral cortisol. Given the role of the HPA axis in cognition, this pattern may contribute to PTSD symptoms and interfere with key processes of standard first-line treatments, such as trauma-focused cognitive behavioural therapy (TF-CBT).

Methods
This review provides a comprehensive summary of the current state of research regarding the role of HPA axis functioning in PTSD symptoms and treatment.

Results
Overall, there is preliminary evidence that hypocortisolaemia contributes to symptom manifestation in PTSD; that it predicts non-responses to TF-CBT; and that it is subject to change in parallel with positive treatment trajectories. Moreover, there is evidence that genetic and epigenetic alterations within the genes NR3C1 and FKBP5 are associated with this hypocortisolaemic pattern and that some of these alterations change as symptoms improve over the course of treatment.

Conclusions
Future research priorities include investigations into the role of the HPA axis in day-to-day symptom variation, the time scale in which biological changes in response to treatment occur, and the effects of sex. Furthermore, before conceiving augmentative or alternative treatments that target the described mechanisms, multilevel studies are warranted.
Evaluation of cardiac function and systolic dyssynchrony of fetuses exposed to maternal autoimmune diseases using speckle tracking echocardiography
Authors: Duan ShaSha , Ha Si , Li ShuJuan , Wang YaXi , Shi YiLu , Zhao HaiYue , Zhang Lu , Zhang XiaoShan , Wang Yong 
Published: April 2021

Abstract
Objectives
To compare cardiac function and systolic dyssynchrony of fetuses not exposed to and those exposed to maternal autoimmune antibodies using two-dimensional speckle tracking echocardiography (2DSTE).

Methods
An observational study of 52 fetuses, 18 from mothers with autoimmune antibodies (anti-SSA/Ro60, anti-Ro52 or/and anti-SSB/La) and 34 from healthy mothers without antibodies, was conducted. Maternal baseline characteristics, fetoplacental Doppler parameters, and conventional echocardiographic data were prospectively collected. Systolic global and regional longitudinal strain of left and right ventricle (LV and RV) and the time to peak strain of regional myocardium were measured using 2DSTE. We also calculated the differences in time to peak strain between the LV free wall and RV free wall (two-chamber dyssynchrony, 2C-DYS) and the LV dyssynchrony between the septum and LV free wall (one-chamber dyssynchrony, 1C-DYS).

Results
There were no significant differences in conventional systolic and diastolic functional parameters for the LV and RV. No effect modification was demonstrated in a myocardial deformation analysis. However, 1C-DYS was significantly more prolonged in the maternal autoimmune disease group (19.50 [8.00 to 29.25] vs. 28.50 [13.50 to 39.25], P = 0.042).

Conclusions
LV systolic mechanical dyssynchrony in fetuses of mothers with autoimmune antibodies suggests in-utero subclinical damage of the cardiac conduction system.

Key points• The left ventricular systolic dyssynchrony was significantly more prolonged in the maternal autoimmune disease (AD) fetuses.• Subclinical damage to the left ventricular conduction system of the fetal heart in maternal AD was observed.• Systolic and diastolic functional of the left and right ventricle were preserved in fetuses exposed to maternal autoimmune disease.
Whole exome sequencing and deep sequencing of esophageal squamous cell carcinoma and adenocarcinoma in Japanese patients using the Japanese version of the Genome Atlas, JCGA
Authors: Booka Eisuke , Tsubosa Yasuhiro , Yokota Tomoya , Mayanagi Shuhei , Ishii Kenjiro , Urakami Kenichi , Ohshima Keiichi , Ohnami Shumpei , Nagashima Takeshi , Yamaguchi Ken 
Published: April 2021

Abstract
Background
Recent comprehensive mutation analyses have revealed a relatively small number of driver mutations in esophageal cancer, implicating a limited number of molecular targets, most of which are also implicated in squamous cell carcinoma.

Methods
In this study, we investigated genetic alterations in 44 esophageal squamous cell carcinomas (ESCC) and 8 adenocarcinomas (EAC) from Japanese patients as potential molecular targets, based on data from the Japanese version of The Genome Atlas (JCGA).

Results
Esophageal cancer was characterized by TP53 somatic mutations in ESCC (39/44, 88.6%) and EAC (5/8, 62.5%). In addition to TP53 mutations, somatic mutations in NFE2L2 (16/44, 36.4%), CDKN2A (7/44, 15.9%), and KMT2D (7/44, 15.9%) were more frequently detected in ESCC than in EAC. WRN-truncated type mutations that lead to genomic instability correlate with EAC, but not ESCC. ESCC samples were enriched in ALDH2-associated mutational signature 16 as well as the APOBEC signature. Patients with FAT2 mutations had significantly poorer overall survival compared with those with wild-type status at FAT2 (p < 0.05). Patients with EP300 or PTPRD mutations also had poor progression-free survival compared with respective wild-types (p < 0.05 or p < 0.001).

Conclusions
These findings may facilitate future precision medicine approaches based on genomic profiling in ESCC and EAC.
Maximally Entangled SU(1,1) Semi Coherent States
Authors: Obada A.-S. F. , Ahmed M. M. A. , Ali Hoda A. , Abd-Elnabi Somia , Sanad S. 
Published: April 2021

AbstractIn this paper, we consider a special type of maximally entangled states namely by entangled SU(1,1) semi coherent states by using SU(1,1) semi coherent states(SU(1,1) Semi CS). The entanglement characteristics of these entangled states are studied by evaluating the concurrence.We investigate some of their nonclassical properties,especially probability distribution function,second-order correlation function and quadrature squeezing . Further, the quasiprobability distribution functions (Q-functions) is discussed.
Towards a three-part heuristic framework for technology education
Authors: Nordlöf Charlotta , Norström Per , Höst Gunnar , Hallström Jonas 
Published: April 2021

AbstractThere is not one single global version of technology education; curricula and standards have different forms and content. This sometimes leads to difficulties in discussing and comparing technology education internationally. Existing philosophical frameworks of technological knowledge have not been used to any great extent in technology education. In response, the aim of this article is to construct a heuristic framework for technology education, based on professional and academic technological knowledge traditions. We present this framework as anepistemological tripod of technology educationwith mutually supporting legs. We discuss how this tripod relates to a selection of epistemological views within the philosophy of technology. Furthermore, we apply the framework to the Swedish and English technology curricula, to demonstrate its utility as an analytic tool when discerning differences between national curricula. Each leg of the tripod represents one category of technological knowledge: (1) technical skills, (2) technological scientific knowledge and (3) socio-ethical technical understanding. The heuristic framework is a conceptual model intended for use in discussing, describing, and comparing curriculum components and technology education in general, and potentially also as support for planning and conducting technology teaching. It may facilitate common understanding of technology education between different countries and technology education traditions. Furthermore, it is a potentially powerful tool for concretising the components of technological literacy.
Direct memberships in foreign copyright collecting societies as an entrepreneurial opportunity for music publishers – needs, challenges, opportunities and solutions
Authors: Klingner Stephan , Miller Mihail , Becker Michael , Schumacher Frank 
Published: April 2021

AbstractIn the competitive, increasingly international music business, publishers are developing new ways to increase effectiveness and efficiency of the monetization of the copyrights they own or manage. Driven by various needs, publishers become entrepreneurs in new markets by choosing the path of direct memberships in foreign copyright collecting societies, rather than entrusting sub-publishers or taking the detour through their domestic copyright collecting society. Since with great power comes great responsibility, publishers as entrepreneurs are pursuing various economic opportunities, but at the same time are also facing great challenges. This paper aims at studying the motivation, obstacles and potentials and deriving possible solutions for this step and thus improving the understanding of as well as supporting publishers in this entrepreneurial activity.
Reconstruction scheme for excitatory and inhibitory dynamics with quenched disorder: application to zebrafish imaging
Authors: Chicchi Lorenzo , Cecchini Gloria , Adam Ihusan , de Vito Giuseppe , Livi Roberto , Pavone Francesco Saverio , Silvestri Ludovico , Turrini Lapo , Vanzi Francesco , Fanelli Duccio 
Published: April 2021

AbstractAn inverse procedure is developed and tested to recover functional and structural information from global signals of brains activity. The method assumes a leaky-integrate and fire model with excitatory and inhibitory neurons, coupled via a directed network. Neurons are endowed with a heterogenous current value, which sets their associated dynamical regime. By making use of a heterogenous mean-field approximation, the method seeks to reconstructing from global activity patterns the distribution of in-coming degrees, for both excitatory and inhibitory neurons, as well as the distribution of the assigned currents. The proposed inverse scheme is first validated against synthetic data. Then, time-lapse acquisitions of a zebrafish larva recorded with a two-photon light sheet microscope are used as an input to the reconstruction algorithm. A power law distribution of the in-coming connectivity of the excitatory neurons is found. Local degree distributions are also computed by segmenting the whole brain in sub-regions traced from annotated atlas.
Electromagnetic interference shielding performance of carbon nanostructure reinforced, 3D printed polymer composites
Authors: Verma Pawan , Bansala Taruna , Chauhan Sampat Singh , Kumar Devendra , Deveci Suleyman , Kumar S. 
Published: April 2021

AbstractWe report the electrical, mechanical and electromagnetic interference (EMI) shielding performance of polypropylene random copolymer (PPR)/multi-wall carbon nanotube (MWCNT) nanocomposites enabled via customized fused filament fabrication process. The electro-conductive PPR/MWCNT filament feedstocks were fabricated via shear-induced melt-blending process that allows 3D printing of nanoengineered composites even at higher MWCNT loading (up to 8 wt%). The uniform dispersion of MWCNTs in PPR matrix confirmed via Raman spectroscopy and scanning electron microscopy facilitates better mechanical, electrical and EMI shielding performance. The results furthermore show enhanced shielding properties and higher attenuation for the nanocomposites printed in 90° direction (~ − 37 dB for 8 wt% MWCNT loading). Effective interfacial adhesion between the beads with lesser extent of voids (confirmed via micro-computed tomography) endorsed low transmission loss in nanocomposites printed in 90° direction compared to samples printed in 0° direction. Surface architected structure (frustum shape) reveals higher specific shielding effectiveness (maximum ~ − 40 dBg−1cm3, + 38%) over the plain structure. The realization of excellent shielding effectiveness (~ 99.9% attenuation) of additive manufacturing-enabled PPR/MWCNT nanocomposites demonstrates their potential for lightweight and strong EMI shields.Graphical Abstract
Learning about microbial language: possible interactions mediated by microbial volatile organic compounds (VOCs) and relevance to understanding Malassezia spp. metabolism
Authors: Rios-Navarro Andrea , Gonzalez Mabel , Carazzone Chiara , Celis Ramírez Adriana Marcela 
Published: April 2021

Abstract
Background
Microorganisms synthesize and release a large diversity of small molecules like volatile compounds, which allow them to relate and interact with their environment. Volatile organic compounds (VOCs) are carbon-based compounds with low molecular weight and generally, high vapor pressure; because of their nature, they spread easily in the environment. Little is known about the role of VOCs in the interaction processes, and less is known about VOCs produced by Malassezia, a genus of yeasts that belongs to the human skin mycobiota. These yeasts have been associated with several dermatological diseases and currently, they are considered as emerging opportunistic yeasts. Research about secondary metabolites of these yeasts is limited. The pathogenic role and the molecular mechanisms involved in the infection processes of this genus are yet to be clarified. VOCs produced by Malassezia yeasts could play an important function in their metabolism; in addition, they might be involved in either beneficial or pathogenic host-interaction processes. Since these yeasts present differences in their nutritional requirements, like lipids to grow, it is possible that these variations of growth requirements also define differences in the volatile organic compounds produced in Malassezia species.

Aim of review
We present a mini review about VOCs produced by microorganisms and Malassezia species, and hypothesize about their role in its metabolism, which would reveal clues about host-pathogen interaction.

Key scientific concepts of review
Since living organisms inhabit a similar environment, the interaction processes occur naturally; as a result, a signal and a response from participants of these processes become important in understanding several biological behaviors. The efforts to elucidate how living organisms interact has been studied from several perspectives. An important issue is that VOCs released by the microbiota plays a key role in the setup of relationships between living micro and macro organisms. The challenge is to determine what is the role of these VOCs produced by human microbiota in commensal/pathogenic scenarios, and how these allow understanding the species metabolism. Malassezia is part of the human mycobiota, and it is implicated in commensal and pathogenic processes. It is possible that their VOCs are involved in these behavioral changes, but the knowledge about this remains overlocked. For this reason, VOCs produced by microorganisms and Malassezia spp. and their role in several biological processes are the main topic in this review.
Changes in co-movement and risk transmission between South Asian stock markets amidst the development of regional co-operation
Authors: Khan Muhammad Niaz , Fifield Suzanne G. M. , Tantisantiwong Nongnuch , Power David M. 
Published: April 2021

AbstractThis paper documents evidence of changes in the co-movement of stock returns and risk transmission among four South Asian stock markets over periods of regional market reform and global market instability. The sample period (1993–2015) is disaggregated into three sub-periods: before and after the establishment of the South Asian Federation of Exchanges (SAFE) and after the 2008 Global Financial Crisis. The principal components investigation and cointegration analysis conclude that the co-movement among stock returns in this region altered amidst a change in the institutional context and global economic uncertainty. Using a tetra-variate GARCH-BEKK model, we find that, after the establishment of SAFE, the interactions among the markets increased through volatility spillovers, but decreased through shock spillovers. In addition, there were more shock and volatility spillovers in the last sub-period as compared to the first two sub-periods, indicating that risk transmission across countries increased during the period of uncertainty. In particular, the Indian stock market was a risk spreader in South Asia after the setup of SAFE and its influence on the regional stock markets increased even further after the 2008 Global Financial Crisis.
Brazil’s Community Health Workers Practicing Narrative Medicine: Patients’ Perspectives
Authors: Pinto Rogério Meireles , Rahman Rahbel , Zanchetta Margareth Santos , Galhego-Garcia W. 
Published: April 2021

Abstract
Background
Narrative medicine (NM) encourages health care providers to draw on their personal experiences to establish therapeutic alliances with patients of prevention and care services. NM medicine practiced by nurses and physicians has been well documented, yet there is little understanding of how community health workers (CHWs) apply NM concepts in their day-to-day practices from patient perspectives.

Objective
To document how CHWs apply specific NM concepts in Brazil’s Family Health Strategy (FHS), the key component of Brazil’s Unified Health System.

Design
We used a semi-structured interview, grounded in Charon’s (2001) framework, including four types of NM relationships: provider–patient, provider–colleague, provider–society, and provider–self. A hybrid approach of thematic analysis was used to analyze data from 27 patients.

Key Results
Sample: 18 females; 13 White, 12 “Pardo” (mixed races), 12 Black. We found: (1) provider–patient relationship—CHWs offered health education through compassion, empathy, trustworthiness, patience, attentiveness, jargon-free communication, and altruism; (2) provider–colleague relationship—CHWs lacked credibility as perceived by physicians, impacting their effectiveness negatively; (3) provider–society relationship—CHWs mobilized patients civically and politically to advocate for and address emerging health care and prevention needs; (4) provider–self relationship—patients identified possible low self-esteem among CHWs and a need to engage in self-care practices to abate exhaustion from intense labor and lack of resources.

Conclusion
This study adds to patient perspectives on how CHWs apply NM concepts to build and sustain four types of relationships. Findings suggest the need to improve provider–colleague relationships by ongoing training to foster cooperation among FHS team members. More generous organizational supports (wellness initiatives and supervision) may facilitate the provider–self relationship. Public education on CHWs’ roles is needed to enhance the professional and societal credibility of their roles and responsibilities. Future research should investigate how CHWs’ personality traits may influence their ability to apply NM.
Regenerative Potential of DPSCs and Revascularization: Direct, Paracrine or Autocrine Effect?
Authors: Mattei Vincenzo , Martellucci Stefano , Pulcini Fanny , Santilli Francesca , Sorice Maurizio , Delle Monache Simona 
Published: April 2021

AbstractA new source of mesenchymal stem cells has recently been discovered, the so-called dental pulp derived stem cells (DPSCs) which therefore could represent potentially tools for regenerative medicine. DPSC originate from the neural crest and are physiologically involved in dentin homeostasis; moreover, they contribute to bone remodeling and differentiation into several tissues including cartilage, bone, adipose and nervous tissues. DPSCs have also been shown to influence the angiogenesis process, for example through the release of secretory factors or by differentiating into vascular and/or perivascular cells. Angiogenesis, that has a pivotal role in tissue regeneration and repair, is defined as the formation of new vessels from preexisting vessels and is mediated by mutual and reciprocal interactions between endothelial cells and perivascular cells. It is also known that co-cultures of perivascular and endothelial cells (ECs) can form a vascular network in vitro and also in vivo. Since DPSCs seem to have characteristics similar to pericytes, understanding the possible mechanism of interaction between DPSCs and ECs during neo-angiogenesis is dramatically important for the development of advanced clinical application in the field of regeneration.
Graphical abstract
Anlotinib in the treatment of advanced hepatocellular carcinoma: an open-label phase II study (ALTER-0802 study)
Authors: Sun Yongkun , Zhou Aiping , Zhang Wen , Jiang Zhichao , Chen Bo , Zhao Jianjun , Li Zhiyu , Wang Liming , Bi Xinyu , Zhao Hong , Liu Kan 
Published: April 2021

AbstractPurposeThis study aimed to assess efficacy and safety of anlotinib as a first- or second-line treatment for advanced or metastatic hepatocellular carcinoma (aHCC) and to identify the predictive plasma cytokines on efficacy of anlotinib.MethodsIt was a phase II clinical study. Patients with aHCC were recruited from October 2016 to April 2019 and divided into two cohorts according to previous tyrosine kinase inhibitors (TKIs) therapy. Those without or with prior TKIs were in Cohort 1 or 2, respectively. All patients took anlotinib (12 mg/day, Day1–14, 3 weeks per cycle). The primary endpoint was 12-week progression-free survival (PFS) rate. Relationship between the series plasma cytokine level and the efficacy of anlotinib was analyzed.ResultsEnrolled 26 patients in Cohort 1 and 24 in Cohort 2. In Cohort 1, the 12-week PFS rate was 80.8% [95% confidence interval (CI); 59.8%–91.5%] and median time to progression (TTP) was 5.9 months (95% CI 4.8–6.9). In Cohort 2, the 12-week PFS rate and median TTP was 72.5% (95% CI 48.7%–86.6%) and 4.6 months (95% CI 2.7–10.0), respectively. The median TTP on patients with a baseline plasma level of CXCL1 (C-X-C motif chemokine ligand 1) less than 7.6 ng/μl was significantly longer in both cohorts. The most common grade 3–5 adverse events were hypertension (8%), diarrhea (8%) and hand-foot syndrome (6%).ConclusionAnlotinib showed promising efficacy and safety as a first- or second-line treatment with a continuous TKIs treatment strategy in aHCC. The plasma CXCL1 might be a predictor for the efficacy of anlotinib.