bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aqueous Extract of Nicotiana tabacum Impaired Serum Testosterone and Testicular Weight in Male Wistar Rats
Authors: Nwaji Azubuike Raphael , Ante Iniobong Ating , Nwoke Favour-Ann Kyrian 
Published: November 2021

Background:
Tobacco which is a product of Nicotiana tabacum (N. tabacum) has nicotine as its primary phytochemical. Nicotine has been reported to be an addictive drug and the leading cause of tobacco addiction worldwide. The male reproductive system is known to be highly sensitive to many chemicals and drugs which have been found to pose adverse effects on male reproductive capacity.

Aim:
The aim of this study is to investigate the effect of the aqueous extract of N. tabacum on serum testosterone and testicular weight in male Wistar rats.

Materials and Methods:
A total of 18 male rats weighing (140–230 g) were used for this study. The animals were randomly divided into three groups (A, B, and C), containing six rats each. Group A served as control, whereas Group B and C were orally administered sublethal doses of 20 and 30 mg/kg body weight of the N. tabacum extract, respectively, once per day for 21 days. At the end of the experimental period, all the animals were sacrificed. Blood samples were collected for hormonal assay and both testes were excised and weighed immediately.

Results:
There was a significant decrease (P < 0.05) in the serum testosterone levels of rats treated with the extract in a dose-dependent manner when compared with the control, there was also a significant reduction in the testicular weight of the treated groups when compared to the control group (P < 0.05).

Conclusion:
The results suggest that aqueous extract of N. tabacum at doses of 20 mg/kg and 30 mg/kg when administered for a period of 3-week impaired serum testosterone level, testicular weight, and bodyweight of male Wistar rats.
Oncological Outcomes of High-Risk Prostate Cancer Patients between Robot-Assisted Laparoscopic Radical Prostatectomy and Laparoscopic Radical Prostatectomy in Taiwan
Authors: Liao Chieh-Chun , Lu Yu-Chuan , Tai Huai-Chin , Chen Chung-Hsin , Pu Yeong-Shiau , Huang Chao-Yuan 
Published: November 2021

Objective:
To compare pathological and oncological outcomes between robotic-assisted laparoscopic radical prostatectomy (RaLRP) and laparoscopic radical prostatectomy (LRP) among high-risk prostate cancer patient in a tertiary center in Taiwan.

Materials and methods:
From November 2003 to October 2013, 129 high-risk prostate cancer patients receiving minimally-invasive radical prostatectomy were included. The Kaplan–Meier analysis was used for measuring biochemical recurrence-free survival (BFS). Multivariate logistic regression models and Cox proportional hazards regression models were used to determine predictors of positive surgical margin and BFS.

Results:
Among the 129 high-risk prostate cancer patients included, 80 (62%) patients received LRP and 49 (38%) patients received RaLRP. There was no significant difference of positive surgical margin and biochemical recurrence rate between RaLRP and LRP group (P = 0.802 and 0.292). Higher pathological T stage predicted an increased likelihood of positive margins (OR = 3.44, 95% CI [1.45, 8.18], P = 0.005). Higher initial PSA level (HR = 2.88, 95% CI [1.04, 7.94], P = 0.041) and positive surgical margin (HR = 2.55, 95% CI [1.20, 5.44], P = 0.015) were poor prognostic factors for BFS.

Conclusion:
RaLRP can be considered among high-risk prostate cancer in Asian people with comparable oncological outcomes to LRP. Higher pathological T stage was associated with increased likelihood of positive margins, patients with higher iPSA level and positive surgical margin had worsen biochemical recurrence-free survival.
Management of Urinary Tract Injuries Following Total Hysterectomy
Authors: Hsu Chao-Yu , Law Kim-Seng , Tai Hao-Ping , Chen Hsiang-Lai , Tse Siu-San , Huang Zhon-Min , Weng Wei-Chun , Huang Li-Hua , Lee I-Yen , Tung Min-Che 
Published: November 2021

Objective:
This study elaborated on the clinical experience of patients who underwent urologic management due to urologic complications after receiving a total hysterectomy at a regional hospital.

Materials and methods:
A total of 696 female patients received the four types of total hysterectomy including total abdominal hysterectomy, transvaginal hysterectomy, lapaparoscopic hysterectomy or robotic hysterectomy for variant gynecologic pathologies. Only 22 cases (3.2%) had urologic procedures performed during or after the operations from 2012/1/1 to 2016/6/30.

Results:
Of the 22 cases, thirteen (1.9%) received a series of conservative managements only, including cystoscopy, ureteroscopy, endoscopic ureterotomy, ureteral catheterization or double J stenting during the follow-up period. Nine more complicated cases (1.3%) eventually had definitive management, including repair of the urinary bladder rupture, repair of the vesicovaginal fistula, ureteroureterostomy or ureteroneocystostomy. However, five of these nine cases had both conservative and definitive management. The mean delay interval between the initial management and gynecologic procedure was 19.3 days. For definitive management and the gynecologic procedure, the period was 52.8 days.

Conclusions:
Compared to previous studies, the incidence of urologic injuries following a total hysterectomy in our hospital was similar. From the paper review, it seems early recognition does not improve the outcome but we found a 100% good outcome in patients with definitive management. Copyright © 2017, Taiwan Urological Association. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Long-term Outcomes of Nephrectomy and Inferior Vena Cava Thrombectomy in Patients with Advanced Renal Cell Carcinoma
Authors: Lien Chi-Chih , Liu Kao-Lang , Chou Po-Ming , Lin Wei-Chou , Tai Hui-Ching , Huang Chao-Yuan , Wang Shuo-Meng , Huang Kuo-How , Pu Yeong-Shiau 
Published: November 2021

Background/Purpose:
This study evaluated the long-term outcomes of nephrectomy and inferior vena cava (IVC) thrombectomy in patients with advanced renal cell carcinoma (RCC).

Methods:
From January 1996 to December 2013, we retrospectively collected the clinical data of 31 patients with pathologically confirmed RCC and IVC tumor thrombus. All patients received nephrectomy and IVC thrombectomy. We examined the clinical outcomes, including cancer-specific survival, progression-free survival, and postoperative complications, during a 90-day period. The associated prognostic factors were also analyzed. This study is registered with the National Taiwan University Hospital Research Ethics Committee (number 201305059RINC).

Results:
The median follow-up period was 24 months. Of 20 patients with nonmetastatic disease, 15 developed metastases during the study period. The overall 5-year cancer-specific survival rate was 30.8% in the nonmetastatic group versus 12.5% in the metastatic group. The level of IVC thrombus (Levels I–II vs. Levels III–IV) was not significantly associated with the 5-year cancer-specific survival (P = 0.43). The Fuhrman grade and sarcomatoid type were statistically significant predictors of cancer-specific survival (Fuhrman Grades III–IV vs. Grades I–II: Hazard ratio [HR] = 0.11, P = 0.04; sarcomatoid type: HR = 0.136, P = 0.001). Fuhrman grade, capsular invasion, and positive surgical margins were associated with 1-year progression-free survival (Fuhrman Grades III–IV vs. Grades I–II: HR = 0.08, P = 0.04; capsular invasion: HR = 0.15, P = 0.04; positive surgical margins: HR = 0.16, P = 0.05). The most common perioperative complication was massive blood loss. The most common recurrence sites were bones, liver, and lungs.

Conclusion:
The pathologic Fuhrman grade, sarcomatoid type, positive surgical margins, and capsular invasion were significant predictors of oncological outcomes in patients with advanced RCC and IVC thrombus.
Comparative Analysis between Radical Cystectomy and Trimodality Therapy for Clinical Stage II Bladder Cancer
Authors: Hong Jian-Hua , Lin Yu-Hua , Lu Yu-Chuan , Chiang Yun , Tai Huai-Ching , Huang Kuo-How , Cheng Chia-Hsien , Pu Yeong-Shiau 
Published: November 2021

Objectives:
To analyze the clinicopathologic characteristics and oncologic outcomes between radical cystectomy (RC) and trimodality therapy (TMT) for patients with clinical stage II bladder urothelial carcinoma (UC).

Methods:
Between January 2004 and September 2013, the medical records of 93 consecutive patients with clinical stage II bladder cancer (cT2N0M0) diagnosed at National Taiwan University Hospital were retrospectively reviewed, including 66 with RC and 27 with TMT. Univariate and multivariate Cox regression analyses were performed to determine prognostic factors.

Results:
The median follow-up time was 34.1 months. There were no significant differences between the TMT and RC group with respect to age, gender, cancer grade and the presence of hydronephrosis. The 5-year overall survival rate (74%) and the 5-year cancer specific survival rate (76%) showed comparable results between RC and TMT group. The overall recurrence rate was 38 % (RC: 41% vs. TMT: 30%, p=0.35). Presence of hydronephrosis demonstrated statistically significant association with tumor recurrence (HR: 2.05, 95% CI 1.04-4.04, p=0.04). Patients with diabetes mellitus (DM) were independently correlated with poorer overall survival (HR: 2.73, 95% CI 1.09-6.82, p= 0.03) and cancer-specific survival (HR: 3.32, 95% CI 1.28-8.65, p= 0.01.)

Conclusions:
TMT is an optimal therapeutic option in selected patients with clinical stage II bladder UC. In our study, despite the method of treatment, presence of hydronephrosis increased cancer recurrence risk and DM demonstrated a significantly negative effect on overall survival and cancer-specific survival.
Evaluation of Perioperative Complications and Outcomes of Robot-assisted Radical Nephroureterectomy and Bladder Cuff Excision in a Tertiary Center
Authors: Tai Meng-Che , Chung Hsiao-Jen , Wei Tzu-Chun , Lin Tzu-Ping , Huang Eric Yi-Hsiu , Lu Shing-Hwa , Chang Yen-Hwa , Lin Alex T.L. 
Published: November 2021

Purpose:
For patients with localized upper tract urothelial carcinoma (UTUC), radical nephroureterectomy with ipsilateral bladder cuff excision (RNU + BCE) is the standard treatment. In recent years, robot-assisted RNU with BCE (RaRNU + BCE) has been another choice of surgical intervention. This article was aimed to analyze the efficacy and perioperative outcomes regarding RaRNU + BCE through a single institutional experience.

Patients and Methods:
From March 2012 to November 2015, a total of 54 patients with UTUC were treated with RaRNU + BCE at Taipei Veterans General Hospital. We collected demographic data, histopathological reports, perioperative complications, and oncologic outcomes.

Results:
A total of 54 patients were included in our study. The mean age was 71.9 ± 9.9 (range 48–88) and the mean body mass index was 23.5 ± 2.9 (range: 16.4–30.8). The mean operating time was 314 min (RaRNU: 133.9 ± 41.4 min and RaBCE: 72.9 ± 25.7 min). The mean first docking time was 26.8 ± 7.7 min and the mean second docking time was 16.5 ± 6.7 min. The mean EBL was 87.7 ml. Pathological stage distribution was 22.2%, 27.8%, 13.0%, 31.5%, and 5.6% in pTa, pT1, pT2, pT3, and pT4, respectively. Complications occurred in 7 cases (13%), with 4 Grade I and 3 Grade II by Clavien-Dindo classification. Positive tumor involvement at bladder cuff was noted in three patients, and the bladder recurrence rate was 29.6%. Local recurrence, lymph node metastasis, and distant metastasis were all noted for two patients, respectively. The cancer-specific and overall survival rate was 98.1% and 96.3%.

Conclusions:
Our experience showed that RaRNU + BCE is a technically feasible and safe procedure for selected patients with UTUC.
Tarihi Yapıların 3 Boyutlu Belgelenme Sürecinde Nokta Bulutu Yönteminin Rolü: Yaylak Ulu Camii Örneği
Authors: ÇALIŞIR Kadir 
Published: November 2021

Tarihi yapıların üç boyutlu belgelendirme yöntemleri arasında, hızlı ve doğru veri elde etme özellikleriyle Işık Tespiti ve Mesafe Ölçme (Light Detection and Ranging - LiDAR) sistemleri giderek ön plana çıkmaktadır. Teknolojinin gelişimi ile birlikte özellikle son yıllarda öğrenimi kolay ve kullanıcı dostu olan ara yüzler ile bu ara yüzleri destekleyen yazılımların sayıları giderek artmaktadır. Korunması gereken taşınmaz kültür varlıkları kapsamında olan tarihi yapıların belgelenme sürecinde yersel lazer tarama (YLT) sistemininkullanılması, karmaşık yapıların kısa sürede modellenmesi için umut verici bir teknolojidir.
Bu çalışma kapsamında taşınmaz kültür varlıkları olarak değerlendirilen tarihi eserlerin belgelenmesinin önemi, bu belgeleme sürecinde kullanılan yöntemlerden biri olan yersel lazer tarama sisteminin neden tercih edildiği ve sistem hakkında geniş bir bilgi verilmektedir. Yersel lazer tarama sistemleri ile elde edilen nokta bulutları ile Şanlıurfa ili Bozova ilçesine bağlı Yaylak beldesinde yer alan tarihi Yaylak Ulu Cami’nin 3 boyutlu modeli çıkarılarak belgelenmesi yapılmıştır. Yaylak Ulu Cami’nin 3 boyutlu modelinin oluşturulma sürecinde YLT sistemi ile elde edilen nokta bulutları, ortofoto görüntü verileri kullanılmış olupSCENE yazılımından yararlanılarak 3 boyutlu model oluşturulmuştur.
Brazilian Consensus Guidelines for Hematopoietic Stem Cell Transplantation - Inborn errors of metabolismo
Authors: Gomes Alessandra Araujo , Mello Rodrigues Adriana , Folloni Fernandes Juliana , Daudt Liane , Bonfim Carmem 
Published: November 2021

Hematopoietic stem cell transplantation (HSCT) has the potential to cure a significant proportion of patients with malignant and nonmalignant diseases. The main rationale for HSCT in inborn errors of metabolism (IEM) is based on correcting the decreases enzymes by the donor cells within and outside the intravascular compartment.
In this article, Brazilian Group for Pediatric Bone Marrow Transplantation of the Brazilian Society of Bone Marrow Transplantation and Cellular Therapy (SBTMO) provides a review of HSCT indications in IEM.
AS PESQUISAS EM ENSINO DE GEOGRAFIA E A CATEGORIA ESPACIAL DE PAISAGEM:
Authors: Fonseca Ricardo Lopes 
Published: November 2021

Neste texto é apresentado o Estado da Arte das pesquisas em ensino de Geografia que abordaram a categoria espacial de paisagem, a partir da análise dos artigos publicados em periódicos nacionais, considerando toda a série histórica disponível de forma on-line até o ano de 2016. O objetivo é investigar, a partir das publicações de artigos em periódicos nacionais on-line possibilitando inferir acerca das perspectivas e das tendências das pesquisas no ensino de Geografia que versaram a respeito da paisagem. Foram localizados 1.458 artigos acerca do ensino de Geografia, sendo 35 destes referentes à paisagem, em 187 periódicos avaliados na área de Geografia, considerando-se o Qualis Periódicos quadriênio 2013-2016. Os resultados estão discutidos em dois momentos, o primeiro como um perfil quantitativo e o segundo a partir do tratamento qualitativo, por meio do método de Análise de Conteúdo, de Bardin (1977). Por fim, por ser considerada uma atividade árdua e complexa, o Estado da Arte desenvolve uma ação bastante criteriosa e reflexiva.
Palavras-chave
Paisagem, Pesquisa, Estado da Arte, Ensino de Geografia, Epistemologia.

RESEARCH IN TEACHING GEOGRAPHY AND THE SPACE CATEGORY LANDSCAPE: notes from a literature review

This paper presents a literature review about on teaching Geography from the analysis of articles about landscape published in national journals, considering the entire historical series until 2016, that is available online. The objective is to investigate, from the publication of articles in national journals online, the entire historical series, allowing to infer about the perspectives and trends of research on place. We found 1,458 articles on this theme, 35 of which refer to the landscape, in 187 journals evaluated in the Geography area, considering the Qualis Periodicals quadrennium 2013-2016. The results were discussed in two moments, the first from a quantitative profile and the second as a qualitative treatment, using Bardin's Content Analysis method (1977). Research on the State of the Art has critical and reflective character that assist in the development of new research demands, concepts and paradigms.
Keywords
Landscape, Research, Literature review, Teaching Geography, Epistemology.
STUDY OF THE ANTIHELMINTH PROPERTIES OF COMMON TANSY IN HETERACIDOSIS AND CAPILLARIOSIS OF TURKEYS
Authors: Saroka A. M. 
Published: November 2021

The helminthic diseases of birds are widespread and cause great economic damage. Deworming of birds is one of the effective measures to combat them. For these purposes, mainly chemical synthesis preparations are used. It is established that some plants have antiparasitic properties, among them − Tanacetum vulgare L., widely spread in natural agrophytocoenoses of the Republic of Belarus. Antihelminthic properties of this plant have been studied during heterakidosis and capillaryosis disease of turkeys.
Experience in studying parasitocidal activity of powder from the inflorescences of Tanacetum vulgare L. was conducted on turkeys spontaneously invaded by capillaries and heterakids. It was found out that this preparation is an effective antihelminthic remedy providing complete release of turkeys from nematodes.
The Effects of Performance Expectancy, Effort Expectancy, Facilitating Condition, and Habit on Behavior Intention in Using Mobile Healthcare Application
Authors: Utomo Prio , Kurniasari Florentina , Purnamaningsih Purnamaningsih 
Published: November 2021

South Tangerang Health Office had the responsibility in giving outstanding healthcare services to its resident’s despite of its limitation due Covid-19 pandemic. Some programs were initiated to reduce maternal, babies and toddler mortality, and in the same time reduce the number of malnourished children. The integrated healthcare mobile application called Si Pandai Kemas TangSel had been launched and can be downloaded easily through smartphone. The study is expected to measure the effectiveness of Si Pandai Kemas TangSel using UTAUT approach by measuring the influence of performance expectancy, effort expectancy, facilitating condition and habit toward behavior intention in using Si Pandai Kemas TangSel mobile application. The study showed that the effort expectancy and habit can increase the intention to use Si Pandai Kemas TangSel application. Meanwhile, performance expectancy and facilitating conditions did not affect behavioral intention in using Si Pandai Kemas TangSel application.
FAMILY PLANNING KNOWLEDGE, ATTITUDE AND PRACTICE AMONG WOMEN OF REPRODUCTIVE AGE IN NIMULE PAYAM, SOUTH SUDAN
Authors: Drici Andrew , Eremugo Isaac , Akello Sarah , Andinda Maureen 
Published: November 2021

Purpose: The purpose of this study was to examine family planning Knowledge, Attitude and Practice (KAP) among women of reproductive age in Nimule Payam, South Sudan.
Method: The study used a descriptive cross-sectional design and quantitative approach to explore family planning knowledge, attitude and practice among women of reproductive age in Nimule Payam. The study population consisted of 6,621 women of reproductive age in the Bomas of Anzara (1,930), Jalei(,1521), Olikwi (1,536) and Nimule Central (1,634). A sample size of 342 was determined from the population using the formulae of Leslie. Stratified simple random sampling was employed through a researcher administered structured questionnaire to collect data from the respondents. The data was cleaned, coded and analyzed using EPI-INFO version 7 to generate descriptive statistics and the results were presented in tables.
Results: The study revealed that women of reproductive age in Nimule Payam had high 273 (79.82%) level of family planning knowledge, good 233 (68%) family planning practices and positive attitude towards family planning. The positive attitude towards family planning was because majority 270 (78.97%) believed family planning was safe to use, could not cause infertility 252 (73.82%), cancer 264 (76.93%) and future abortion 251 (73.36%). The respondents also generally agreed that 319 (93.07%) family planning could prevent unwanted pregnancy. However, the majority of the respondents acknowledged that the practice of family planning was against their God/Allah 268 (78.31%) and culture 229 (67.03%).
Unique contribution to theory, practice and policy: The study found that women of reproductive age in Nimule Payam had a high level of family planning knowledge, a fairly positive attitude with a moderate number practicing family planning methods. Increased sensitization of the respondents and their partners on family planning is required to improve their attitude and practice. Future studies should focus on the factors influencing the Knowledge, Attitude and Practice of family planning methods among women of reproductive age in Nimule Payam.
La Educación desde una perspectiva de la complejidad
Authors: Ramírez Ramírez Margarita , Manrique Rojas Esperanza , Plascencia López Ismael 
Published: November 2021

En el presente artículo se realiza una reflexión sobre el enfoque de la complejidad en modelos educativos, los cuales cada día se alejan de modelos reduccionistas ante las carencias que este enfoque de la ciencia presenta. Se analizan características de un sistema complejo como la emergencia, la autoorganización, que caracterizan a los sistemas complejos. Se destaca la complejidad y sus características, como factores indispensables en un modelo educativo que atienda a las necesidades de educación requeridas en un entorno globalizado, cambiante y complejo que presenta desafíos de manera constante. El presente artículo parte del análisis del concepto de reduccionismo, que ha sido un método exitoso para alcanzar avances significativos en la ciencia; sin embargo, ante las condiciones actuales, las necesidades de un mundo globalizado, es necesario imple­mentar nuevos modelos educativos que ofrezcan integración de componentes y análisis holísticos de problemáticas para ser atendidas y resueltas. Se analizan los principios de complejidad y sistemas complejos, para realizar una descripción de un modelo educativo con una perspectiva de la complejidad y paradigmas de complejidad y educación.