bluuebunny/crossref_metadata_2025_split huggingface dataset:
Doxepin prevents the Expression and Development of Paclitaxel-Induced Neuropathic Pain
Authors: Naji Esfahani Hajar , Vaseghi Golnaz , Haghjooy Javanmard Shaghayegh , Pilehvarian Aliasghar 
Published: November 2021

Background:
Peripheral neurotoxicity is a common side effect of many anticancer chemotherapy drugs, including paclitaxel. Peripheral neurotoxicity may present as changes in sensory function and mild paresthesia that, in turn, can lead to alleviation of the prescribed dose of the medication. The aim of this study was to evaluate the effectiveness of acute and chronic doxepin administration on development and expression of neuropathic pain during the treatment of cancer with paclitaxel.

Materials and Methods:
Neuropathic pain was induced in mice by paclitaxel (2 mg/kg, intraperitoneally [i.p.,] once daily from day 1 to day 5) that caused mechanical and cold allodynia. Doxepin was administrated every day from day 6 to 10 (10 and 15 mg/kg i.p.). Mechanical and cold allodynia was evaluated on day 11 of the experiment in both the test and the control group.

Results:
Daily administration of doxepin (2.5, 5, and 10 mg/kg i.p.) from day 1 to 5 significantly inhibited the development of cold and mechanical allodynia. As well doxepin administration (5 and 10 mg/kg i.p.) from the 6th day, to 10th day significantly inhibited cold and mechanical allodynia expression. To address the concerns associated with the effectiveness of chemotherapy agents on the tumor, we evaluated paclitaxel cytotoxicity effect in combination with doxepin. Our observations indicate that doxepin even at high concentrations (1 and 10 μg/ml) does not interfere with the cytotoxic effect of paclitaxel (0.05 μg/ml).

Conclusions:
These results indicate that doxepin, when administered during chemotherapy, can prevent the development and expression of paclitaxel-induced neuropathic pain.
Clinical Profile and Immediate Outcome of Multisystem Inflammatory Syndrome in Children Associated with COVID-19
Authors: Sethy Geetanjali , Mishra Bibhudatta , Jain Mukesh Kumar , Patnaik Sibabratta , Mishra Reshmi , Behera Jyoti Ranjan , Sahoo Bandya , Behera Narendra 
Published: November 2021

Introduction:
Following an asymptomatic or mildly symptomatic coronavirus disease (COVID-19), otherwise healthy children may develop serious manifestations in the form of cardiac, neurological, respiratory, gastrointestinal, and dermatologic dysfunction. Many such cases were being observed in Odisha, an eastern state of India, and have been reported from different health-care facilities. We related these unexplained serious manifestations to multisystem inflammatory syndrome associated with COVID-19 (MIS-C) and planned this study.

Methods:
This retrospective observational study was carried out at the following three tertiary care centers: Kalinga Institute of Medical Sciences, Bhubaneswar; MKCG Medical College, Berhampur; and Jagannath Hospital, Bhubaneswar. The study population included all children aged from 1 month to 18 years admitted to the hospitals with MIS-C according to the WHO diagnostic criteria. All the data were analyzed by SPSS software.

Results:
A total of 21 children were included in our study. Majority of the cases were male (76.2%), and the predominant age group was 6–10 years (47.6%). Common symptoms and signs in our observation included fever, pain abdomen, seizure, and hypotension. Most of these cases were positive for severe acute respiratory syndrome coronavirus antibody (80.95%). Response to immunotherapy was dramatic. Mortality (9%) of our study was higher than 1.8%–3% from that of Western literature. None of our patients had coronary abnormality, while two patients had mild cardiac dysfunction at discharge comparable to that of other studies.

Conclusion:
MIS-C following exposure to COVID-19 infection in children is a clinical syndrome, which needs early suspicion and appropriate intervention to prevent mortality.
Corneal transplant epidemiology in a reference center in Bogotá, Colombia (2010-2017)
Authors: Mora Matilde , Cortés María Cristina , Plata María Camila , Acosta Daniel Suárez 
Published: November 2021

Purpose:
To describe the characteristics of the donor and recipient, indications, surgical techniques, and survival results obtained from patients with corneal transplants performed at Fundación Oftalmológica Nacional (FUNDONAL) between 2010 and 2017.

Methods:
Descriptive, observational study. Medical records of patients who underwent corneal transplantation were reviewed. Demographic data, surgery indication, transplantation technique, graft transparency, and presence of rejection are evaluated. Statistical analysis was performed with the SPSS software version 21.0.

Results:
Seven hundred and twelve eyes from 690 patients who underwent corneal transplantation were analyzed. The median age of the recipient was 42 years (interquartile range 21.8 years) and 392 participants (56.8%) were men. Corneal ectasias was the first indication for transplantation. The technique performed most often was penetrating keratoplasty (PK) (89.6%), followed by deep anterior lamellar keratoplasty (5.3%), endothelial keratoplasty (3.5%), and sclerokeratoplasty (1.5%). 22.25% of the cases presented at least one rejection episode. Transparency of the graft is >80% up to 36 months from follow-up.

Conclusions:
In 712 eyes that underwent corneal transplantation between 2010 and 2017, the most frequent indications were corneal ectasias, pseudophakic/aphakic bullous keratopathy, and previous graft failure. Although the most common technique is PK, there is a tendency to perform more lamellar transplants over the years. Survival up to the last control was 78% with graft rejection at 22.23%, which are comparable with results reported in the scientific literature. This study constitutes the first corneal transplant registry in Colombia, with survival results and description of variables that will allow for the identification of risk factors for undesirable outcomes.
Oil and Gas Projects in Sultanate of Oman: Construction Schedule and Cost Overrun
Authors: Al Sadi Hani , Dawood Mahmoud 
Published: November 2021

Oil and Gas (O&G) industry is the primary source of the gross national income in gulf area. This industry is facing construction related issues that lead to cost overrun and delay in construction schedule of the construction related tasks. During COVID 19 pandemic, Sultanate of Oman O&G construction projects are facing many problems due to many factors. As a result and use these factors, about 70% of the major projects suffer from schedule slip and increasing costs. This has direct impact on the government budget with about 15% of GDP. This research is discussing the main factors and its root causes that have direct impact on construction cost and schedule for O&G projects. This is has been done based on the literature and the conducted survey.
Knowledge on Sexually Transmitted Infections (STIs) and sexual practices among Nursing Trainees in Yendi Municipality, Northern Region of Ghana
Authors: Mutaru Abdul-Manaf , Asumah Mubarick , Ibrahim Mohammed , Sumaila Issah , Hallidu Mustapha , Mbemah Joachim , Atakole Baba , Zakaria Dawud 
Published: November 2021

Purpose: This study aimed to assess the knowledge on Sexually Transmitted Infections (STIs) and sexual practices among nursing trainees in Yendi Municipality, Northern Ghana.
Methodology: The study was conducted in Northern Ghana, using a cross-sectional study design. The study recruited 265 students using a multistage sampling technique. A self-reported questionnaire was used for the data collection. Data were analyzed using Stata version 16 and p-value < 0.05 was considered statistically significant.
Findings: Majority (54.0%) of the respondents were males (69.1%), below 25 years with a mean age of 23.5 ±2.4 years. Most students (33.2%) had their first sexual relationship before 20 years of age. Only 20.4% of the students reported having had STIs in the past six months. Nine out of ten (90.9%) respondents have heard of STIs. Among the respondents who had ever heard of STIs, majority (71.7%) heard about STIs in school, followed by the media (41.1%), friends (33.2%), and relatives (29.4%). Majority (75.0%) of students had sufficient knowledge of STIs. The association between knowledge on STIs and program of study (X2=7.6, p=0.023), gender (X2=3.93, p=0.047), and age (X2=22.3, p=0.039) were statistically significant. The odds of sufficient knowledge of STIs for students pursuing Registered Mental Nursing (RMN) is 3 times that of those studying RNAC program (AOR=3.4, 95%CI=1.23 – 9.55, p-value=0.019). Respondents aged ≥25 years were 1.8 times more likely to have sufficient knowledge compared with those below 25 years (AOR=1.8, 95%CI=0.91 – 3.38, p=0.047).
Recommendation: There is the need for sensitizations and intensifying education since not all students were armed with the required information on STIs. Stakeholders including, the Ministry of Health, Ghana Health Service, Islamic Medical Association of Ghana (IMAGH), Christian Health Association of Ghana (CHAG) and Tutors of health training institutions ought to re-evaluate the current interventions, and protocols on STIs prevention. There is also the need to regulate media content on health by the National Media Commission and the Ministry of Health of Ghana and its affiliates to ensure the right information on STIs is channelled to listeners by qualified persons.
Patterns of Wisdom in Safavid Iran
Authors: Esots Janis 
Published: November 2021

The exceptional intellectual richness of seventeenth-century Safavid Iran is epitomised by the philosophical school of Isfahan, and in particular by its ostensible founder, Mir Damad (d. 1631), and his great student MullaSadra (aka Sadr al-Din Shirazi, d. 1636). Equally important to the school is the apophatic wisdom of Rajab ‘Ali Tabrizi that followed later (d. 1669/70).
However, despite these philosophers’ renown, the identification of the ‘philosophical school of Isfahan’ was only proposed in 1956, by the celebrated French Iranologist Henry Corbin, who noted the unifying Islamic Neoplatonist character of some 20 thinkers and spiritual figures; this grouping has subsequently remained unchallenged for some fifty years.
In this highly original work, Janis Esots investigates the legitimacy of the term ‘school’, delving into the complex philosophies of these three major Shi’i figures and drawing comparisons between them. The author makes the case that MullaSadra’s thought is independent and actually incompatible with the thoughts of Mir Damad and Rajab Ali Tabrizi. This not only presents a new way of thinking about how we understand the ‘school of Isfahan’, it also identifies Mir Damad and Rajab Ali Tabrizi as pioneers in their own right.
Northern Irish Writing After the Troubles
Authors: Magennis Caroline 
Published: November 2021

Winner of the British Association for Comtemporary Literary Stuides (BACLS) monograph prize
The period since the Good Friday Agreement in 1998 has seen a sustained decrease in violence and, at the same time, Northern Ireland has undergone a literary renaissance, with a fresh generation of writers exploring innovative literary forms.
This open access book explores contemporary Northern Irish fiction and how the ‘post’-conflict period has led writers to a renewed engagement with intimacy and intimate life. Magennis draws on affect and feminist theory to examine depictions of intimacy, pleasure and the body in their writings and shows how intimate life in Northern Ireland is being reshaped and re-written.
Featuring short reflective pieces from some of today’s most compelling Northern Irish Writers, including Lucy Caldwell, Jan Carson, Bernie McGill and David Park, this book provides authoritative insights into how a contemporary engagement with intimacy provides us with new ways to understand Northern Irish identity, selfhood and community.
The ebook editions of this book are available open access under a CC BY-NC-ND 4.0 licence on http://bloomsburycollections.com.
Trauma, Primitivism and the First World War
Authors: Porter Joy 
Published: November 2021

This book examines the extraordinary life of Frank “Toronto” Prewett and the history of trauma, literary expression, and the power of self-representation after WWI.
Joy Porter sheds new light on how the First World War affected the Canadian poet, and how war-induced trauma or “shell-shock” caused him to pretend to be an indigenous North American. Porter investigates his influence of, and acceptance by, some of the most significant literary figures of the time, including Siegfried Sassoon, Edmund Blunden, Wilfred Owen and Robert Graves.
In doing so, Porter skillfully connects a number of historiographies that usually exist in isolation from one another and rarely meet. By bringing together a history of the WWI era, early twentieth century history, Native American history, the history of literature, and the history of class Porter expertly crafts a valuable contribution to the field.
Liability Insurance in International Arbitration
Authors: Jacobs Sir Richard , Masters Lorelie S , Stanley Paul 
Published: November 2021

The Bermuda Form
This is the third revised edition of what was described by the English Court of Appeal in C v D as the ‘standard work’ on Bermuda Form excess insurance policies. The Form, first used in the 1980s, covers liabilities for catastrophes such as serious explosions or mass tort litigation and is now widely used by insurance companies. It is unusual in that it includes a clause requiring disputes to be arbitrated under English procedural rules in London but subject to New York substantive law. This calls for a rare mix of knowledge and experience on the part of the lawyers involved, each of whom is required to confront the many differences between English and US law and legal culture. In addition, since the awards of arbitrators are confidential and are not subject to the scrutiny of the courts, the book helps professionals understand the Form’s lengthy and complex provisions.
The book, first published in 2004, was the first comprehensive analysis of the Bermuda Form. It is frequently cited in Bermuda Form arbitrations and was the joint winner in 2012 of British Insurance Law Association Book Prize for the most notable contribution to literature in the field of law as it affects insurance. It offers a detailed commentary on how the Form is to be construed, its coverage, the substantive law to be applied, the limits of liability, exceptions, and, of course, the procedures to be followed during arbitration proceedings in London. The book will prove invaluable to lawyers, risk managers, and executives of companies which purchase insurance on the Bermuda Form, and to clients, lawyers or arbitrators involved in disputes arising therefrom.
The Assessment of the Efficiency of Cell Therapy of Experimental Liver Cirrhosis by Means of Ultrasound Examination
Authors: Osipov B. B. , Lyzikov A. N. , Skuratov A. G. , Prizentsov A. A. 
Published: November 2021

Objective: to determine the relevance of ultrasound examination in diagnostics and assessment of the efficiency of cell therapy of experimental liver cirrhosis in rabbits.Material and methods. The experiment was performed on white Californian rabbits (n = 45). Liver cirrhosis was modelled by means of subcutaneous injections of 50 % solution of carbon tetrachloride according to the scheme. Cell therapy was performed by means of a single intraportal injection of autologous mesenchymal stem cells (MSCs) at an amount of 5 × 106 cells per kg. During the experiment all the animals were performed the ultrasound examination of the abdominal cavity, as well as the morphological analysis of liver tissue samples.Results. After 5 months of the liver cirrhosis modeling, the anteroposterior liver size and diameter of the portal vein in group 2 and group 3 were statistically larger than in group 1 (р < 0.001, Mann-Whitney test). There was no statistical difference in the anteroposterior liver size (р = 0.38) and diameter of the portal vein (р = 0.36) between group 2 and group 3. 1 month after the injection of autologous MSCs, the rabbits of group 3 detected some improvement of the echimage of the damaged liver, which was also reflected in a statistically significant decrease of the liver size by 8.2 % (р < 0.01, Wilcoxon test) and diameter of the portal vein by 23 % (р < 0.001) in comparison with the indicators before the injection of MSCs.Conclusion. The ultrasound examination in the present study has proved itself to be a reliable method of intravital diagnostics of pathological changes in the conditions of a chronic experiment, and also has revealed a positive impact of cell therapy on liver cirrhosis in the rabbits. The obtained data were confirmed by the morphological methods of the analysis of the liver tissue samples of the animals during the experiment.
Analysis of Heart Rate Variability in Young Athletes of a School of Оlympic Reserve
Authors: Rubchenya I. N. , Sukach E. S. , Merkis A. P. 
Published: November 2021

Objective: to study the parameters of heart rate variability (HRV) and autonomic reactivity in response to an orthostatic test in young athletes of a school of Olympic Reserve.Material and methods. The mathematical and spectral methods of the HRV analysis with the application of the 12-channel electrocardiograph «Poly-Spectrum-8» were used for the evaluation of vegetative tone, autonomic support, and autonomic reactivity.Results. Statistically significant differences in the activity of the ANS were revealed in the examined athletes with aerobic and anaerobic types of physical exercise during their one-year training. In response to the orthostatic exposure in the athletes doing aerobic exercise, the sympathetic department of regulation is activated and centralization of the control over the heart rhythm is strengthened. In the young athletes involved in high-speed power sports, the vegetative reactivity is characterized by a higher degree of activation of humoral-metabolic regulation mechanisms than in the athletes specializing in endurance sports.Conclusion. The study of the HRV parameters and analysis of autonomic reactivity in response to the orthostatic test in the young athletes of the school of Olympic Reserve during the preparatory and competitive periods make it possible to apply an individual approach to the training process taking into account the prevailing type of autonomic regulation and autonomic reactivity, which contributes to an elevated level of the functional readiness of the athletes for training activities.
Systems Analysis of Earthquake Source Status and Its Applications
Authors: Зимина С. А. , Зимин М. И. 
Published: November 2021

Рассматривается системный анализ состояния очага землетрясений и его применение. Оценивается влияние сейсмических событий на окружающую среду. Приводятся примеры расчёта.
The study proposes systems analysis of earthquake source status and its applications. The impact of seismic events on the environment is estimated. The analysis examples are included.
A comparative study of two-way and offline coupled WRF v3.4 and CMAQ v5.0.2 over the contiguous US: performance evaluation and impacts of chemistry–meteorology feedbacks on air quality
Authors: Wang Kai , Zhang Yang , Yu Shaocai , Wong David C. , Pleim Jonathan , Mathur Rohit , Kelly James T. , Bell Michelle 
Published: November 2021

Abstract. The two-way coupled Weather Research and Forecasting and Community Multiscale Air Quality (WRF-CMAQ) model has been developed to more
realistically represent the atmosphere by accounting for complex
chemistry–meteorology feedbacks. In this study, we present a comparative
analysis of two-way (with consideration of both aerosol direct and indirect
effects) and offline coupled WRF v3.4 and CMAQ v5.0.2 over the contiguous
US. Long-term (5 years from 2008 to 2012) simulations using WRF-CMAQ with both
offline and two-way coupling modes are carried out with anthropogenic
emissions based on multiple years of the U.S. National Emission Inventory
and chemical initial and boundary conditions derived from an advanced Earth
system model (i.e., a modified version of the Community Earth System
Model/Community Atmospheric Model). The comprehensive model evaluations show that both two-way WRF-CMAQ and WRF-only simulations perform well for major
meteorological variables such as temperature at 2 m, relative humidity at 2 m, wind speed at 10 m, precipitation (except for against the National Climatic Data Center data), and shortwave and longwave radiation. Both two-way and offline CMAQ also show good performance for ozone (O3) and fine particulate matter (PM2.5). Due to the consideration of aerosol
direct and indirect effects, two-way WRF-CMAQ shows improved performance
over offline coupled WRF and CMAQ in terms of spatiotemporal distributions
and statistics, especially for radiation, cloud forcing, O3, sulfate, nitrate, ammonium, elemental carbon, tropospheric O3 residual, and column nitrogen dioxide (NO2). For example, the mean biases have been reduced by more than 10 W m−2 for shortwave radiation and cloud radiative forcing and by more than 2 ppb for max 8 h
O3. However, relatively large biases still exist for cloud predictions,
some PM2.5 species, and PM10 that warrant follow-up studies to
better understand those issues. The impacts of chemistry–meteorological
feedbacks are found to play important roles in affecting regional air
quality in the US by reducing domain-average concentrations of carbon
monoxide (CO), O3, nitrogen oxide (NOx), volatile organic
compounds (VOCs), and PM2.5 by 3.1 % (up to 27.8 %), 4.2 % (up to
16.2 %), 6.6 % (up to 50.9 %), 5.8 % (up to 46.6 %), and 8.6 %
(up to 49.1 %), respectively, mainly due to reduced radiation,
temperature, and wind speed. The overall performance of the two-way coupled
WRF-CMAQ model achieved in this work is generally good or satisfactory and
the improved performance for two-way coupled WRF-CMAQ should be considered
along with other factors in developing future model applications to inform
policy making.
Sosialisasi Program Bersih Pantai dan Edukasi Kepada Masyarakat Lingkungan Pantai Bali Lestari Desa Pantai Cermin Kanan
Authors: Astika Wanhar Fira , Widodo Hadi 
Published: November 2021

Desa Pantai Cermin Kanan yang memiliki potensi yang sangat besar untuk dikembangkan jika program-program yang ada pada pemerintah dapat ditindak lanjuti secara bersama-sama oleh pemerintah, masyarakat dan perguruan tinggi. Desa Pantai Cermin Kanan dimiliki letak demografi dan topografi yang sangat mendukung kegiatan dan aktivitas kepariwisataan seperti wisata bahari, penyediaan sarana perhotelan dan pantai yang berpasir putih sangat diminati untuk dikunjungi oleh wisatawan. Kesadaran masyarakat khususnya pengunjung Pantai Bali Lestari Desa Pantai Cermin Kanan akan pentingnya menjaga kebersihan lingkungan masih sangat kurang karena masih ada masyarakat yang membuang sampah sembarangan terutama sampah plastik bekas pembungkus makanan yang dibiarkan berserakan di sekitar pantai. Pentingnya pemahaman konsep Tri Hita Karana bagi masyarakat sejak dini sehingga kebersihan lingkungan dpaat dinikmati oleh semua masyarakat serta kemamfaatan umum dapat dicapai melalui sosialisasi dan aksi sosial kebersihan lingkungan. Hasil dari pengabdian masyarakat yang tim lakukan banyak sekali dampaknya Pertama, selama berlangsungnya pengabdian, masyarakat sempat antusias berpartisipasi dalam pelaksanaan sosialisasi dan aksi social kebersihan pantai yang dilakukan oleh tim pelaksana pengabdian dari awal sampai berakhirnya acara. Pada dasarnya masyarakat menyadari akan pentingnya menjaga kebersihan pantai guna melestarikan lingkungan dan meningkatkan kualitas kesehatan. Namun dalam pelaksanaan meningkatkan pemahaman tersebut dibutuhkan motivasi lebih lanjut baik dari pemerintah maupun dari organisasi pecinta lingkungan