bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decadal Geomagnetic Secular Variations From Greigite Bearing Dead Sea Sediments
Authors: Ebert Yael , Shaar Ron , Stein Mordechai 
Published: April 2021

AbstractArcheomagnetic data from the Levant revealed periods within the Holocene with fast and extreme changes in the geomagnetic field. Yet, the availability of the archeomagnetic data is sporadic and the correlation with the available sedimentary records from the region is rather poor. To further explore decadal variations in the directions of the field, we investigate three outcrops of the late Holocene Dead Sea that are exposed along the western retreating shores of the modern lake. The sediments were deposited under spatially varying limnological‐environmental conditions, influencing their magnetic properties. The southern section, located near Ein‐Gedi Spa (EG section) is dominated by detrital titanomagnetite whereas the northern sections, Nahal Og (Og section) and Ein‐Feshkha (EF section), are dominated by authigenic greigite. The chronology of the sections was established by radiocarbon dating of short lived organic debris. The magnetic data were obtained in a 2 cm resolution. The EF section, spanning the time interval from ca. 2,500 cal yr BP to ca. 1,000 cal yr BP, is dominated by greigite and thus providing the most robust geomagnetic record with precise paleomagnetic directions. Greigite forms very early in the sediment and the effects of smoothing and the inclination shallowing are negligible. The new data reveal a maximal deviation of 20° from the geocentric axial dipole field between 2,400 to 2,200 cal yr BP accompanied with a fast swing in inclination from 60° to 35° over about a century. This suggests high geomagnetic field activity associated with the Levantine Iron Age geomagnetic anomaly.
Relative importance of organic- and iron-based colloids in six Nova Scotian lakes
Authors: Anderson Lindsay E. , Trueman Benjamin F. , Dunnington Dewey W. , Gagnon Graham A. 
Published: April 2021

AbstractDissolved organic matter (DOM) concentrations have been increasing in parts of the northern hemisphere for several decades. This process—brownification—often accompanies increasing iron and aluminum, but the metal–DOM interactions these concurrent trends imply are poorly described. Here we used field-flow fractionation with UV and ICP-MS detection to measure the size distribution of colloidal iron, aluminum, manganese, copper, uranium, and chromophoric DOM in six lakes over six months. Five of these lakes have browned to some degree in the past three decades, with linear increases in organic carbon and color ranging from 0.01 to 0.13 mg C L−1 yr−1 and 0.13–1.94 PtCo yr−1. Browning trends were more pronounced and colloids more abundant in lakes with wetlands in their catchments. Iron and aluminum were present in two primary fractions, sized nominally at 1 and 1000 kDa. The 1 kDa fraction included the primary DOM signal, while the 1000 kDa fraction absorbed minimally at 254 nm and likely represents iron-rich (oxyhydr)oxides. Colloidal manganese was sized at 1000+ kDa, whereas colloidal copper and uranium occurred primarily at 1 kDa. These associations fit with a pattern of increasing DOC, iron, aluminum, and color in the region’s lakes. They represent a significant challenge for drinking water treatment systems, especially those in remote communities. Given that browning trends are expected to continue, monitoring plans would better inform treatment process design and operation by characterizing DOM and iron-rich, primarily inorganic colloids that contribute to adverse water quality outcomes.
Gene expression profiling of brain endothelial cells after experimental subarachnoid haemorrhage
Authors: Tso Michael K. , Turgeon Paul , Bosche Bert , Lee Charles K. , Nie Tian , D’Abbondanza Josephine , Ai Jinglu , Marsden Philip A. , Macdonald R. Loch 
Published: April 2021

AbstractSubarachnoid haemorrhage (SAH) is a type of hemorrhagic stroke that is associated with high morbidity and mortality. New effective treatments are needed to improve outcomes. The pathophysiology of SAH is complex and includes early brain injury and delayed cerebral ischemia, both of which are characterized by blood–brain barrier (BBB) impairment. We isolated brain endothelial cells (BECs) from mice subjected to SAH by injection of blood into the prechiasmatic cistern. We used gene expression profiling to identify 707 unique genes (2.8% of transcripts, 403 upregulated, 304 downregulated, 24,865 interrogated probe sets) that were significantly differentially expressed in mouse BECs after SAH. The pathway involving prostaglandin synthesis and regulation was significantly upregulated after SAH, including increased expression of the Ptgs2 gene and its corresponding COX-2 protein. Celecoxib, a selective COX-2 inhibitor, limited upregulation of Ptgs2 in BECs. In this study, we have defined the gene expression profiling of BECs after experimental SAH and provide further insight into BBB pathophysiology, which may be relevant to other neurological diseases such as traumatic brain injury, brain tumours, ischaemic stroke, multiple sclerosis, and neurodegenerative disorders.
Motor and sensory features successfully decode autism spectrum disorder and combine with the original RDoC framework to boost diagnostic classification
Authors: Harrison Laura A. , Kats Anastasiya , Kilroy Emily , Butera Christiana , Jayashankar Aditya , Keles Umit , Aziz-Zadeh Lisa 
Published: April 2021

AbstractSensory processing and motor coordination atypicalities are not commonly identified as primary characteristics of autism spectrum disorder (ASD), nor are they well captured in the NIMH’s original Research Domain Criteria (RDoC) framework. Here, motor and sensory features performed similarly to RDoC features in support vector classification of 30 ASD youth against 33 typically developing controls. Combining sensory with RDoC features boosted classification performance, achieving a Matthews Correlation Coefficient (MCC) of 0.949 and balanced accuracy (BAcc) of 0.971 (p = 0.00020, calculated against a permuted null distribution). Sensory features alone successfully classified ASD (MCC = 0.565, BAcc = 0.773, p = 0.0222) against a clinically relevant control group of 26 youth with Developmental Coordination Disorder (DCD) and were in fact required to decode against DCD above chance. These findings highlight the importance of sensory and motor features to the ASD phenotype and their relevance to the RDoC framework.
Serum-derived exosomal PD-L1 expression to predict anti-PD-1 response and in patients with non-small cell lung cancer
Authors: Shimada Yoshihisa , Matsubayashi Jun , Kudo Yujin , Maehara Sachio , Takeuchi Susumu , Hagiwara Masaru , Kakihana Masatoshi , Ohira Tatsuo , Nagao Toshitaka , Ikeda Norihiko 
Published: April 2021

AbstractPD-L1 expression is the most useful predictive biomarker for immunotherapy efficacy on non-small cell lung cancer (NSCLC), and CD8+ tumor-infiltrating lymphocytes (CD8+ TILs) play an essential role in the clinical activity of immunotherapy. PD-L1 is found on the exosome’s surface, and PD-L1 expressing exosomes can inhibit antitumor immune responses. This study aimed to analyze tumor PD-L1 expression, serum exosomal PD-L1, and CD8+ TILs to investigate anti-PD-1 response and clinicopathological outcomes in NSCLC. One hundred twenty patients with stage I–III NSCLC were enrolled, and serum samples collected during the initial surgery were pooled. The Human CD274/PD-L1 ELISA kit was used to quantify the exosomal PD-L1. Exosomal PD-L1 levels were significantly correlated with tumor PD-L1 levels (p < 0.001) and the number of CD8+ TILs (p = 0.001). Patients with exosomal PD-L1 ≥ 166 pg/mL tended to have a worse RFS than those with < 166 pg/mL in all stage (p = 0.163) and stage I patients (p = 0.116). Seventeen patients exhibited postoperative recurrences and received anti-PD-1 treatment. The disease control rate of patients with exosomal PD-L1 ≥ 166 pg/mL was 100%. The measurement of serum exosomal PD-L1 as a quantitative factor with tumor PD-L1 status may help predict anti-PD-1 response and clinical outcomes in patients with NSCLC.
Enhancing carbohydrate repartitioning into lipid and carotenoid by disruption of microalgae starch debranching enzyme
Authors: Kato Yuichi , Oyama Tomoki , Inokuma Kentaro , Vavricka Christopher J. , Matsuda Mami , Hidese Ryota , Satoh Katsuya , Oono Yutaka , Chang Jo-Shu , Hasunuma Tomohisa , Kondo Akihiko 
Published: April 2021

AbstractLight/dark cycling is an inherent condition of outdoor microalgae cultivation, but is often unfavorable for lipid accumulation. This study aims to identify promising targets for metabolic engineering of improved lipid accumulation under outdoor conditions. Consequently, the lipid-rich mutant Chlamydomonas sp. KOR1 was developed through light/dark-conditioned screening. During dark periods with depressed CO2 fixation, KOR1 shows rapid carbohydrate degradation together with increased lipid and carotenoid contents. KOR1 was subsequently characterized with extensive mutation of the ISA1 gene encoding a starch debranching enzyme (DBE). Dynamic time-course profiling and metabolomics reveal dramatic changes in KOR1 metabolism throughout light/dark cycles. During light periods, increased flux from CO2 through glycolytic intermediates is directly observed to accompany enhanced formation of small starch-like particles, which are then efficiently repartitioned in the next dark cycle. This study demonstrates that disruption of DBE can improve biofuel production under light/dark conditions, through accelerated carbohydrate repartitioning into lipid and carotenoid.
High-resolution stereolithography using a static liquid constrained interface
Authors: Bhanvadia Aftab A. , Farley Richard T. , Noh Youngwook , Nishida Toshikazu 
Published: April 2021

Abstract3D printing using conventional stereolithography is challenging because the polymerized layers adhere to the solid constraining interface. The mechanical separation forces lead to poor process reliability and limit the geometrical design space of the printed parts. Here, these challenges are overcome by utilizing a static inert immiscible liquid below the resin as the constraining interface. We elucidate the mechanisms that enable the static liquid to mitigate stiction in both discrete layer-by-layer and continuous layerless growth modes. The inert liquid functions as a dewetting interface during the discrete growth and as a carrier of oxygen to inhibit polymerization during the continuous growth. This method enables a wide range of process conditions, such as exposure and resin properties, which facilitates micrometer scale resolutions and dimensional accuracies above 95%. We demonstrate multi-scale microstructures with feature sizes ranging from 16 μm to thousands of micrometers and functional devices with aspect ratios greater than 50:1 without using sacrificial supports. This process can enable additive 3D microfabrication of functional devices for a variety of applications.
Multi‐factor joint normalisation for face recognition in the wild
Authors: Liu Yanfei , Chen Junhua 
Published: April 2021

AbstractFace recognition has become very challenging in unconstrained conditions due to strong intra‐personal variations, such as large pose changes. Face normalisation can help to resolve these problems and effectively improve the face recognition performance in unconstrained conditions by converting non‐frontal faces to frontal ones. However, there are other complex facial variations in addition to pose, such as illumination and expression, which will also influence face recognition performance. The authors propose a well‐designed generative adversarial network‐based multi‐factor joint normalisation network (MFJNN) to normalise multiple factors simultaneously. First, a multi‐encoder generator and a feature fusion strategy are designed and implemented in the MFJNN to realise the joint normalisation of multiple factors in addition to pose. Second, a convolutional neural network‐based (CNN‐based) network is applied in the MFJNN, which allows the MFJNN to simultaneously realise image synthesis and facial representation learning. Moreover, an identity perceptive loss is introduced based on the CNN‐based network to produce reliable identity‐preserving features of the input face images. The experimental results demonstrate that the proposed method can synthesise multi‐factor normalisation results with identity preservation and effectively improve the face recognition performance.
Demonstration of super‐Gaussian apodized linearly chirped fiber Bragg grating for efficient beam steering in Ku‐band applications
Authors: Srivastava Nimish Kumar , Raghuwanshi Sanjeev Kumar , Parihar Reena 
Published: April 2021

AbstractThis paper demonstrates a photonic‐based wideband TTD beamforming will demonstrate network employing super‐Gaussian apodized chirped fiber Bragg grating (SGFBG) of different lengths (each having central wavelength of 1550 nm) such as 5, 4.5, 4, 3.5, 3, 2.5, 2, 1.5 cm as well as varying chirp rate, which can be used as variable TTD lines for controlling the radiation angle of PAA (the main lobe radiated by the PAA can be steered squint‐free between 0° and ± 69°) suitable for continuous beamforming at microwave frequencies in Ku‐band (12‐18 GHz). The experimental demonstration shows the effect of change in laser wavelength on delay incurred within the reflected light from the SGFBG. This delay in modulated optical signal will be converted into delayed microwave signal feed to respective element of PAA after passing through photodetector. Finally, the time‐delayed microwave signal feeded to each element of PAA will be responsible for tilt in microwave signal compared to the horizontal direction. Novelty of the proposed SGFBG as compared to linearly chirped fiber Bragg grating (LCFBG) is in terms of reduction in ripples in delay spectrum which will lead to exact delay introduction in the optical signal.
Bionic organization as a stage of production enterprise development in a digital transformation process
Authors: Cherepanov Vitalii , Popov Evgeny , Simonova Victoria 
Published: April 2021

This article embraces a concept of bionic organization as a form of production enterprise which main attribute is an integration of digital technologies in the management processes and the production lines from the product idea to its delivery to a consumer. Digital technologies reinforce human competencies and abilities of analogous machines, playing a role of independent component of executive and production system. At the same time, digital technologies become full-fledged members of the organization, enriching it with bionic treats.
An idea of full human substation in production management with digital technologies is far from being practicable, but a tendency towards this change is quite clear. The main purpose of this this article is to discover main features of bionic organization as an intermediate evolution stage on the way of full human substitution with machines and digital technologies. Additionally, the article focuses on the interconnections between bionic organization, digital transformation, digital maturity and management system. This analysis was made for a production enterprise set upon a way to deep digital transformation.
Gemeinsame Handlungsempfehlung (S1-Leitlinie) von DGN, OGNMB und SGNM – Radiosynoviorthese – Stand: 9/2019 – AWMF-Registernummer: 031-023
Authors: Gabriel Michael , Pöppel Thorsten D. , Freudenberg Lutz S. , Farahati Jamshid , Krause Thomas , Buchmann Inga , Panholzer Peter J. , Mödder Gynter , Becherer Alexander , Kampen Willem U. , Kurth Jens , Krause Bernd J. , Wissmeyer Michael , Kresnik Ewald ,   Weitere Beteiligte,   Deutsche Gesellschaft für Rheumatologie e. V. (DGRh),   Deutsche Schmerzgesellschaft e. V.
Published: April 2021

ZusammenfassungDiese Handlungsempfehlung soll eine Grundlage für die Qualitätssicherung der Radiosynoviorthese (RSO) bei entzündlichen (nichtinfektiösen) Gelenkerkrankungen schaffen. Sie wurde interdisziplinär erarbeitet und beschreibt die allgemeine Zielsetzung, Definitionen, klinische Hintergrundinformationen und Kontraindikationen dieser Radionuklidtherapie. Aufgeführt werden die Anforderungen, die an ein Behandlungszentrum gestellt werden, prätherapeutisch notwendige Untersuchungsbefunde sowie Empfehlungen, wie die Behandlung technisch und organisatorisch durchgeführt werden sollte. Ferner finden sich Angaben zur Kontrolle und Nachsorge der therapierten Patienten. Grundsätzlich sollen Behandlung und Nachsorge in Abstimmung und Zusammenarbeit der beteiligten Fachdisziplinen erfolgen.
Infektionsmanagement bei drohender Frühgeburt – eine Umfrage an deutschen Perinatalzentren
Authors: Pech Theresa , Gerber Bernd , Stubert Johannes 
Published: April 2021

Zusammenfassung
Einleitung Internationalen und nationalen Leitlinien fehlt es an detaillierten Empfehlungen zur Infektionsdiagnostik und -therapie bei drohender Frühgeburt. Ziel der Studie war es, Daten zur Versorgungssituation an deutschen Perinatalzentren zu erheben.
Methoden Onlineumfrage zum Infektionsmanagement bei drohender Frühgeburt an allen 212 deutschen Perinatalzentren der Versorgungsstufen Level I und II.
Ergebnisse Die Rücklaufquote betrug 31,6% (n=67). Bei drohender Frühgeburt unter 34 vollendeten SSW ohne Blasensprung verzichten 78,8% auf eine kalkulierte Antibiotikagabe. Von den verbleibenden vierzehn Zentren (21,2%) würde die Hälfte generell bei klinischen Zeichen einer drohenden Frühgeburt antibiotisch behandeln. Fast alle Zentren (94%) führen eine vaginale Erregerdiagnostik durch. Eine mikroskopische Abstrichbeurteilung mittels Nugent- oder Amsel-Score erfolgt in 37,3%. Abweichungen von der physiologischen vaginalen Mikrobiota werden mehrheitlich antibiotisch behandelt (bakterielle Vaginose 79,1%, n=53, Candida spp. 77,6%, n=52, Ureaplasma spp. 49,3%, n=33). Kontrollabstriche erfolgen in 70,1%. Konsens besteht hinsichtlich einer Antibiotikagabe bei frühem vorzeitigem Blasensprung. 72,6% bevorzugen eine Monotherapie mit einem β-Laktam-Antibiotikum. Uneinheitlich waren hier die Angaben zur Dauer der Therapie, wobei 58% der Zentren länger als sieben Tage behandeln.
Schlussfolgerung An deutschen Perinatalzentren besteht eine hohe Bereitschaft zur Infektionsdiagnostik und -therapie bei drohender Frühgeburt. Das Infektionsmanagement ist jedoch uneinheitlich und partiell widersprüchlich zu den vorliegenden Leitlinien. Es besteht ein Bedarf an qualitativ hochwertigen Studien zu diesem Thema.
COVID-19: ambulante oder stationäre Betreuung? – Risikoscore zur prospektiven Differenzierung leichter und schwerer Verläufe
Authors: Peters Lynn , Burkert Sanne , Dinse-Lambracht Alexander , Peifer Johannes , Grüner Beate 
Published: April 2021

ZusammenfassungWährend die Zahl an Personen, die sich mit SARS-CoV-2 infizierte, über eine lange Zeit stieg, nahmen die Behandlungskapazitäten in den Krankenhäusern entsprechend ab. Um Patienten nicht zu gefährden und gleichzeitig Ressourcen zu schonen, ist eine frühzeitige Differenzierung zwischen prognostisch leichten und schweren Verläufen erforderlich. Zur Identifikation von COVID-19-Fällen mit stationärem Behandlungsbedarf wurde zu Beginn der Pandemie ein COVID-19-Risikoscore basierend auf einer Literaturrecherche und ersten klinischen Erfahrungen erstellt und im Rahmen einer retrospektiven Kohortenstudie mit 155 Patienten validiert. Aufgrund des hohen prädiktiven Wertes und der Diskriminierungsfähigkeit kann der etablierte COVID-19-Risikoscore ein unterstützendes Instrument für klinisch tätige Ärzte an der Sektorengrenze zwischen ambulantem und stationärem Bereich darstellen.
Crossover from a delocalized to localized atomic excitation in an atom–waveguide interface
Authors: Jen H H , You J-S 
Published: April 2021

Abstract
An atom–waveguide system, which presents one of the quantum interfaces that enable strong couplings between light and atoms, can support tightly-confined guided modes of light. In this distinctive quantum interface, we theoretically investigate the crossover from a delocalized to localized atomic excitation under long-range dipole–dipole interactions and lattice disorders. Both localization lengths of the excitation distributions and power-law scalings of dissipative von Neumann entanglement entropy show signatures of this crossover. We further calculate numerically the level statistics of the underlying non-Hermitian Hamiltonian, from which as the disorder strength increases, the gap ratio decreases and the intrasample variance increases before reaching respective saturated values. The mean gap ratio in the deeply localized regime is close to the one from Poisson statistics along with a relatively large intrasample variance, whereas in the nondisordered regime, a significant level repulsion emerges. Our results provide insights to study the non-ergodic phenomenon in an atom–waveguide interface, which can be potentially applied to photon storage in this interface under dissipations.
Electronic and optical properties of tapered tetrahedral semiconductor nanocrystals
Authors: Na Guangren , li Yawen , Wang Xiaoyu , Fu Yuhao , Zhang Lijun 
Published: April 2021

Abstract
The quantum confinement effect resulting from size reduction drastically alters the electronic structure and optical properties of optoelectronic materials. Quantum confinement in nanomaterials can be efficiently controlled by morphology variation combined characteristics of nanomaterials, such as their size, shape, and spatial organization. In this study, considering indium arsenide (InAs) in tetrahedral semiconductors as an example, we demonstrated the controllable morphology evolution of InAs nanostructures by tuning the growth conditions. We used the atomistic pseudopotential method to investigate the morphology-dependent electronic and optical properties of InAs nanostructures: tapered and uniform nanostructures, including the absorption spectra, single-particle energy levels, distribution and overlap integral of band-edge states, and exciton binding energies. Compared with uniform nanomaterials, a weaker quantum confinement effect was observed in the tapered nanomaterials, because of which tapered InAs nanostructures have a smaller bandgap, larger separation of photoinduced carriers, and smaller exciton binding energy. The absorption spectra of InAs nanostructures also exhibit strong morphology dependence. Our results indicate that morphology engineering can be exploited as a potential approach for modulating the electronic and optoelectronic properties of nanomaterials.
Power density improvement based on investigation of initial relative position in an electromagnetic energy harvester with self-powered applications
Authors: Peng Yan , Zhang Dong , Luo Jun , Xie Shaorong , Pu Huayan , Li Zhongjie 
Published: April 2021

Abstract
In this paper, we originally report a breakthrough in the power density of a novel electromagnetic energy harvester to scavenge ambient low-frequency vibration energy. The harvester adopted a configuration of alternating south- and north-pole magnet array, which causes a step-change in magnetic flux density, contributing to high electromotive force output. Through analysis of the coil configuration and the initial relative position between coils and magnets, the harvester can take full advantage of the abrupt flux density change, which enhances its output power significantly. Experimental results adequately validated the simulation analysis regarding the correlation between the initial relative position and output power, and exhibited a high output performance. Namely, the maximum average power and power density the harvester yields are 44.8 mW and 1.6

mW

c

m

−
3

, respectively, with the optimum resistance of 30 Ω at resonance under the excitation of 1 g. It took the harvester around 5 min to charge a button lithium battery up to 21%. Meanwhile, a LED array composed of 180 diodes was successfully lighted up, and a calculator was powered for around 630 s within a 20 s of charging period. This research shows great potential in the development of self-powered systems.