bluuebunny/crossref_metadata_2025_split huggingface dataset:
Przymus przemiany. Serial „Hannibal” jako krytyka kultury terapeutycznej
Authors: Koprowicz Agata 
Published: October 2021

The article is an analysis of the Hannibal series (2013–2015) made by Bryan Fuller with reference to therapeutic culture. Hannibal is presented as a manifestation of the critique of contemporary culture, which focuses on the relationship of subject and power in therapeutic culture in Western liberal societies. The main thread that has been analysed is the relationship between the main characters: Will Graham and Hannibal Lecter.
The article presents the origin of therapeutic culture and the category of “psychological man” (P. Rieff). The relationship between Will and Hannibal is not a meta-image of contemporary therapeutic culture in general, but its dark face. The series shows the culture of therapy brought to its limits, where norms are not so much exceeded, but subverting.
Hannibal Lecter is presented as the “ideal self” of liberal societies, an entity free from cultural norms in an absolute way. Will is opposed to him. His personality does not allow classification, just as a modern subject does not want to be classified, because it would mean pinning him to one place and making it impossible for him to develop.
An important problem in the article is “coercion of change”. The “right to change” legitimised by the liberal system changes into “coercion of change” in the series. The requirement of “full life” means that standing in a place is something undesirable, live in a real way is to experience of something new, to change — even if it means a transformation into a murderer. In the end it is argued that “being yourself” is an effect of power in therapeutic culture.
„Self-tracking” jako zjawisko kulturowe wspierające procesy samopoznania
Authors: Smołucha Danuta 
Published: October 2021

The article analyses the popularity of self-tracking as one cultural phenomenon. The practice of tracking one’s activity and controlling life parameters is not new, but nowadays it has been popularised and entered into a group of new, cultural trends. This process is strongly related to the development of technology, the Internet of Things and mobile solutions. On the other hand, to outline the full picture of the phenomenon of self-tracking, it should be considered in different cultural contexts, taking into account social factors and current fashions and trends.
Modelagem paramétrica baseada em objetos em BIM para o projeto estrutural
Authors: Ribeiro Renan Rocha , César Júnior Kléos Magalhães Lenz 
Published: October 2021

A modelagem paramétrica baseada em objetos constitui paradigma natural e essencial da Modelagem da Informação da Construção (BIM), potencializando a automação e contribuindo para a manutenção da consistência entre as informações do modelo. Estudos de sua potencialidade e aplicação prática ao projeto estrutural são importantes para a difusão do conceito entre os profissionais desta disciplina. O presente trabalho visa explorar a modelagem paramétrica baseada em objetos em BIM, no contexto do projeto de estruturas, por meio do estudo de caso de fundações tipo tubulão, utilizando a plataforma Autodesk Revit. O delineamento do estudo de caso segue: (i) apresentação de conceitos e etapas da modelagem paramétrica baseada em objetos no Revit; (ii) detalhamento do processo de modelagem paramétrica baseada em objetos de uma Família de fundações tipo tubulão; (iii) aplicação da Família modelada no contexto de um modelo real. O trabalho apresenta conceitos, estratégias e práticas para a modelagem paramétrica de elementos estruturais, além de um mapa de processo que descreve a utilização de objetos paramétricos no contexto de um projeto estrutural que tire proveito da modelagem paramétrica baseada em objetos em BIM. Foi observado que a modelagem paramétrica baseada em objetos em um ambiente BIM para projetos estruturais é tecnicamente viável e apresenta vantagens e benefícios a serem explorados pelos profissionais da área. Entretanto, a estrutura rígida de classes a nível de categoria na plataforma Revit restringe a modelagem paramétrica baseada em objetos oferecida exigindo soluções paliativas.
SuperPATH Total Hip Arthroplasty
Authors: Avshalumov Stanislav , Frane Nicholas , Stapleton Erik James , Aberman Zachary , Bandovic Ivan , Wicker Alex 
Published: October 2021

Introduction:
The supercapsular percutaneously assisted total hip (SuperPATH) approach and technique are a relatively new minimally invasive procedure for total hip replacement. The theoretical benefits include muscle sparing, no hip precautions, smaller incision, decrease in blood loss, and a relative familiar approach for joint surgeons. The aim of our study was to assess the early results and learning curve using the SuperPATH technique.

Methods:
A retrospective cohort analysis of the first 28 SuperPATH hip replacements by a single surgeon was performed. The learning curve was assessed by evaluating the results of 2 groups of 14 cases grouped in order in which they were performed. Group 1 was comprised of the first 14 cases, and group 2 of the last 14 cases. Primary measures included operative time and blood loss as surrogates of technical improvement. Secondary measures recorded were length of stay, acetabular component inclination angle, postoperative leg length discrepancy, and intraoperative complications. Descriptive statistics were used to describe the patient cohort, and comparative testing was performed to determine differences between the groups. Statistical significance was defined as p < 0.05.

Results:
The duration of the operative procedure between the first 14 cases and the last 14 cases was statistically significant (p = 0.045), 162.85 and 142.67 minutes, respectively. The length of stay was also statistically significant (p = 0.020) between the 2 groups, 3.5 and 2.5 days, respectively. There was no difference between the groups for blood loss, acetabular inclination angle, and leg length discrepancy.

Conclusions:
This study found a gradual decrease in operative time without plateau between the 2 groups, suggesting that operative time will continue to decrease in the future. Future research will include an extended follow-up of the study group to determine longer-term outcomes and complications. Furthermore, a larger sample size will be needed to determine when the learning curve levels off for this procedure.

Level of Evidence:
Level IV.
Low-Frequency Admittance of Capacitor with Working Substance “Insulator–Partially Disordered Semiconductor– Insulator”
Authors: Poklonski N. A. , Anikeev I. I. , Vyrko S. A. 
Published: October 2021

The study of the electrophysical characteristics of crystalline semiconductors with structural defects is of practical interest in the development of radiation-resistant varactors. The capacitance-voltage characteristics of a disordered semiconductor can be used to determine the concentration of point defects in its crystal matrix. The purpose of this work is to calculate the low-frequency admittance of a capacitor with the working substance “insulator–crystalline semiconductor with pointt-defects in charge states (−1), (0) and (+1)–insulator”. A layer of a partially disordered semiconductor with a thickness of 150 μm is separated from the metal plates of the capacitor by insulating layers of polyimide with a thickness of 3 μm. The partially disordered semiconductor of the working substance of the capacitor can be, for example, a highly defective crystalline silicon containing pointt-defects randomly (Poissonian) distributed over the crystal in charge states (−1), (0), and (+1), between which single electrons migrate in a hopping manner. It is assumed that the electron hops occur only fromt-defects in the charge state (−1) tot-defects in the charge state (0) and fromt-defects in the charge state (0) tot-defects in the charge state (+1).In this work, for the first time, the averaging of the hopping diffusion coefficients over all probable electron hopping lengths viat-defects in the charge states (−1), (0) and (0), (+1) in the covalent crystal matrix was carried out. For such an element, the low-frequency admittance and phase shift angle between current and voltage as the functions on the voltage applied to the capacitor electrodes were calculated at thet-defect concentration of 3∙1019cm−3for temperatures of 250, 300, and 350 K and at temperature of 300 K for thet-defect concentrations of 1∙1019, 3∙1019, and 1∙1020 cm−3.
Two Weeks High Glucose is Enough to Induce Liver and Gut Lesion
Authors: Min Cunyun , Fu Tingting , Du Yu , Tan Wei , Huang Xuhui , Zhan Feng 
Published: October 2021

Abstract
Background:High glucose is critical for diabetes.But in which way it induces diabetes, and which organ trigger the formation of diabetes are not clear.The goal of this study is to see if there is a risk of acquiring diabetic symptoms following a 2 weeks short infusion of 2g/kg/day and dietary 2.5g/kg/day in SD rats on various body organs.Methods：Twelve weeks old SD rats were randomly divided into control group,high glucose infusion group(IHG,infusion 2g/kg/day) and oral high glucose group OHG,dietary 2.5g/kg/day).Fasten blood sugar,TNF-a and IL-6 were measured. Intestine and liver samples were collected for pathological examination.Feces of rats were collected for gut microbiota tests.Results：The results indicated that short time high glucose induced hyperglycemia lasted for at least 2 weeks after ceasing of high glucose.It increased serum levels of IL-6 and TNF-a obviously.It led to jejunum mucosa injury, obvious steatosis of hepatocytes, and disturbed the balance of gut microbiota.OHG led to swelling and necrosis of individual intestinal villi.IHG led to necrosis and disappearence of cells in the upper layer of intestinal mucosa.The lesion was confined to the mucosa.Conclusions:Short time high glucose induced lesion in liver and intestine,disturbed the balance of gut microbiota and consequently induced inflammation and triggered diabetes.
Adenosine Inhibits TNFα-Induced MMP-3 Production in MH7A RA Synoviocytes via A2A Receptor Signaling
Authors: Konishi Hiroe , Kanou Shun-En , Yukimatsu Rika , Inui Mizuki , Sato Motoya , Yamamoto Naruto , Nakano Masayoshi , Koshiba Masahiro 
Published: October 2021

Abstract
Adenosine is the effector molecule; however, the contributions of synoviocyte adenosine receptors (AdoRs) are unknown, and matrix metalloproteinase 3 (MMP-3) is released by fibroblast-like synoviocytes in response to inflammatory signaling. To elucidate the therapeutic mechanisms of methotrexate, we investigated the effects of A2A AdoR activation and inhibition on tumor necrosis factor-alpha (TNFa)-induced MMP-3 release by MH7A human rheumatoid synovial cells. MH7A cells constitutively expressed membrane-associated A2A AdoRs, and HENECA enhanced intracellular cAMP. Stimulation with TNFa markedly enhanced release of MMP-3 from MH7A cells, whereas HENECA partially and dose-dependently inhibited TNFa-evoked MMP-3 release. Similarly, dbcAMP partially inhibited TNFa-induced MMP-3 release. Pretreatment with ZM241385 reversed the inhibitory effects of HENECA. Further, TNFa induced p38 MAPK and ATF-2 phosphorylation, whereas HENECA suppressed p38 MAPK and ATF-2 phosphorylation. We concluded that adenosine signaling via A2A AdoRs, adenylyl cyclase, and cAMP reduces TNFa-induced MMP-3 production by interfering with p38 MAPK/ATF-2 activity. Activation of A2A AdoR pathway and suppression of MMP-3 release may explain the antirheumatic effects of methotrexate.
Functional Changes and Threats to Hyperseasonal Neotropical Savannas After Australian Acacia Invasion
Authors: Meira-Neto João Augusto Alves , Villa Pedro Manuel , Silva Nathália , Silva Maria Carolina Nunes Alves da , Tolentino Glaucia , Buttschardt Tillmann , Ulm Florian , Maguas Cristina 
Published: October 2021

Abstract
The hyperseasonal savanna experiences regular flooding and drought stresses and is a neotropical vegetation type threatened by global change including Acacia spp. invasion. To deepen the understanding of hyperseasonal savannas after Acacia invasion in a climate change scenario, we aimed to answer if: i) the plants of the studied hyperseasonal savanna are separated into C3, C4 or CAM species; ii) Acacia invasion can change the hyperseasonal savanna functioning for C3, C4 and CAM plants; iii) how invasive Acacia uptake water compared to native species in this hyperseasonal savanna. We detected both C3 and C4 metabolic groups of plants but two C3 species are possibly CAM facultative. The functioning of C3 plants as a group was not affected by the Acacia invasion, but this result does not exclude a species turnover between C3 herbs and C3 trees. The C4 plants of invaded Mussununga lost their response of increasing water use efficiency to the increasing Leaf N%. Plants of hyperseasonal savannas depend on the same water source as the soil water from recent rains. There are differences in d18O among species because some grow mostly during the rainy season with the 18O-enriched water meanwhile the invader Acacia mangium grows throughout the year whenever it rains. According to our results, the threat to C4 plants is high and they can be excluded from Mussunungas and from hyperseasonal savannas. However, hyperseasonal savannas are threatened as a vegetation. Therefore, hyperseasonal savannas should be considered critically endangered because of global change, especially bacause Acacia invasions. Initiatives for conservation of hyperseasonal savannas could save these remarkable ecosystems.
The Development of Theory-Informed Participant-Centred Interventions to Maximise Participant Retention in Randomised Controlled Trials
Authors: Newlands Rumana , Duncan Eilidh , Treweek Shaun D , Elliott Jim , Presseau Justin , Bower Peter , MacLennan Graeme , Ogden Margaret , Wells Mary , Witham Miles , Young Bridget , Gillies Katie 
Published: October 2021

Abstract
BackgroundA failure of clinical trials to retain participants can influence the trial findings and significantly impact the potential of the trial to influence clinical practice. Retention of participants involves people, often the trial participants themselves, performing a behaviour (e.g. returning a questionnaire or attending a follow-up clinic as part of the research). Most existing interventions that aim to improve the retention of trial participants fail to describe any theoretical basis for the potential effect (on behaviour) and also whether there was any patient and/or participant input during development. The aim of this study was to address these two problems by developing theory- informed, participant-centred, interventions to improve trial retention. MethodsThis study used a multi-phase sequential mixed methods approach informed by the Theoretical Domains Framework and Behaviour Change Techniques Taxonomy to match participant reported determinants of trial retention to theoretically informed behaviour change strategies. The prototype interventions based on participant accounts were described and developed in a co-design workshop with trial participants. We then assessed acceptability and feasibility of two of the prioritised retention interventions during a focus group, which also included a questionnaire, involving a range of trial stakeholders (e.g. trial participants, trial managers, research nurses, trialists, research ethics committee members). ResultsEight trial participants contributed to the co-design of the retention interventions. Four behaviour change interventions were designed based on suggestions provided by trial participants: 1. Incentives and rewards for follow-up clinic attendance; 2. Goal setting for improving questionnaire return; 3. Self-monitoring to improve questionnaire return and/or clinic attendance; and 4. Motivational information to improve questionnaire return and clinic attendance. Seventeen trial stakeholders (participants, trialists, ethics committee members) contributed to the evaluation of acceptability and feasibility of the retention interventions, which were generally positive with some areas for consideration highlighted. ConclusionsThis is the first study to develop interventions to improve trial retention that are based on the accounts of trial participants and also conceptualised and developed as behaviour change interventions (to encourage attendance at trial research visit or return a trial questionnaire). Further testing of these interventions is required to assess their effectiveness and assess resource implications.
QTLs Detection for Low-Temperature Germination in Rapeseed by QTL-seq and Linkage Mapping Approach
Authors: Zhu Jifeng , Wang Weirong , Jiang Meiyan , Yang Liyong , Zhou Xirong 
Published: October 2021

Abstract
Rapeseed is a major oil crop in the world, which is easily affected by low-temperature stress. Low-temperature delays seed germination and increases seedling mortality that adversely affects rapeseed growth and production. To understand the genetic mechanisms of seed germination under low-temperature in rapeseed, we crossed a tolerant cultivar with a susceptible genotype to develop a mapping population of 574 F2 progenies. Two quantitative trait loci (QTLs) for low-temperature germination (LTG) were detected on chromosome A09 (named qLTGA9-1) and C01 (named qLTGC1-1) using QTL-seq method, and confirmed via linkage analysis in the mapping population. qLTGA9-1 was mapped to a 341.86-kb interval between SSR markers Nys9A212 and Nys9A215. In this region, 69 genes including six specific genes with moderate or high effect function variant were identified based on Ningyou7 genome sequence. qLTGC1-1 was mapped a 1.31-Mb interval between SSR markers Nys1C96 and Nys1C117. In this region, 133 genes including five specific genes with moderate effect function variant were identified based on Ningyou7 genome sequence. These specific genes within the two QTLs could be targets in rapeseed breeding programs and further studies for cold tolerance.
Influencing Factors of Multiple Adverse Outcomes Among Schizophrenia Patients Using Count Regression Models: A Cross-Sectional Study
Authors: Chen Lichang , Tan Wenyan , Lin Xiao , Lin Haicheng , Xi Junyan , Zhang Yuqin , Jia Fujun , Hao Yuantao 
Published: October 2021

Abstract
Background: Schizophrenia patients have increased risks of several adverse outcomes, including violent crime, aggressiveness and suicide. However, studies of different adverse outcomes in the same population are rare and the influencing factors for these outcomes need clarification by appropriate models. This study aimed to identify influencing factors of these adverse outcomes by examining and comparing different count regression models.Methods: This study included schizophrenia patients who had at least once follow-up record in the Guangdong Mental Health Center Network Medical System during 2020. Three types of adverse outcomes including a) aggressiveness with police dispatch or violence crime, b) aggressiveness without police dispatch, and c) self-harm or suicide attempts. First, we investigated the incidence of these adverse outcomes in each type. Second, the Poisson, negative binomial (NB), zero-inflated Poisson (ZIP), and zero-inflated negative binomial (ZINB) regression models were fitted and compared for their intensity. Finally, We analysed associations between these adverse outcomes intensity and sociodemographic, clinical factors with the best model. Results: A total of 130474 schizophrenia patients were selected. Each type of adverse outcomes was reported by less than 1% of schizophrenia patients in 2020. NB regression model is the best model for fitting the number of aggressiveness without police dispatch because of the best goodness of fit and relatively simple interpretation, whereas ZINB models for the other two outcomes. Age, sex, and history of adverse outcomes were influencing factors shared across these adverse outcomes. Higher educational level, employment were protective factors shared between aggressiveness with police dispatch or violent crime , and aggressiveness without police dispatch. Aggressiveness without police dispatch , and self-harm or suicide attempts shared older onset age (≥18 years) as a risk factor. Family history of mental disease was a risk factor of self-harm or suicide attempts individually.Conclusions: NB and ZINB models were selected for fitting the number of adverse outcomes in our studies. Influencing factors for adverse outcomes intensity included both those shared across different types and those individual to specific types. Therefore, combined and customized tools in risk assessment and intervention for different types of these outcomes might be necessary.
Directional proton conductance in bacteriorhodopsin is driven by concentration gradient, not affinity gradient
Authors: Ren Zhong 
Published: October 2021

Abstract
It is widely spread that microorganisms can harvest energy from sun light to establish electrochemical potential across cell membrane by pumping protons outward. Light driven proton pumping against a transmembrane gradient entails exquisite electronic and conformational reconfiguration at fs to ms time scales. However, transient molecular events along the photocycle of bacteriorhodopsin are difficult to comprehend from noisy electron density maps obtained from multiple experiments when the intermediate populations coexist and evolve as a function of 13 decades of time. Here I report an in-depth meta-analysis of the recent time-resolved datasets collected by several consortiums. This analysis deconvolutes the observed mixtures, thus substantially improves the quality of the electron density maps, and provides a clear visualization of the isolated intermediates from I to M. The primary photoproducts revealed here suggest a proton transfer uphill against 15 pH units is accomplished by the same physics that governs the tablecloth trick. While the Schiff base is displaced at the beginning of the photoisomerization within ~30 fs, the proton stays due to its inertia. This affinity-independent early deprotonation builds up a steep proton concentration gradient that drives the directional proton conductance toward the extracellular medium. This mechanism fundamentally deviates from the widely adopted assumption based on equilibrium processes driven by light-induced changes of proton affinities. The method of a numerical resolution of concurrent events from mixed observations is also generally applicable.