bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validating Star-Oddi heart rate and acceleration data storage tags for use in Atlantic salmon (Salmo salar)
Authors: Zrini Zoe Amanda , Gamperl A. Kurt 
Published: March 2021

Abstract
Background
Data storage tags (DSTs) record and store information about animals and their environment, and can provide important data relevant to fish culture, ecology and conservation. A DST has recently been developed that records heart rate (fH), electrocardiograms (ECGs), tri-axial acceleration and temperature. However, at the time of this study, no research using these tags had been performed on fish or determined the quality of the data collected. Thus, our research asked: do these DSTs provide reliable and meaningful data? To examine this question, Atlantic salmon (1.4 ± 0.7 kg) were implanted with DSTs, then swam at increasing speeds in a swim tunnel after 1 week of recovery. Further, in two separate experiments, salmon (2.4 ± 0.1 kg) were implanted with DSTs and held in a large tank with conspecifics for 1 week at 11 °C or 6 weeks at 8–12 °C.

Results
External acceleration (EA) and variation in EA (VAR) increased exponentially with swimming speed and tail beat frequency. The quality index (QI) assigned to ECG recordings (where QI0 means very good quality, and QI1, QI2 and QI3 are of reduced quality) did not change significantly with increasing swimming speed (QI0 ~ 60–80%). However, we found that the accuracy of the tag algorithm in estimating fH from ECGs was reduced when QI>0. Diurnal patterns of fH and EA were evident from the time the salmon were placed in the tank. Heart rate appeared to stabilize by ~ 4 days post-surgery in the first experiment, but extended holding showed that fH declined for 2–3 weeks. During extended holding, the tag had difficulty recording low fH values < 30 bpm, and for this reason, in addition to the fact that the algorithm can miscalculate fH, it is highly recommended that ECGs be saved when possible for quality control and so that fH values with QI>0 can be manually calculated.

Conclusions
With these DSTs, parameters of acceleration can be used to monitor the activity of free-swimming salmon. Further, changes in fH and heart rate variability (HRV) due to diurnal rhythms, and in response to temperature, activity and stressors, can be recorded.
Very preterm infants engage in an intervention to train their control of attention: results from the feasibility study of the Attention Control Training (ACT) randomised trial
Authors: Perra Oliver , Wass Sam , McNulty Alison , Sweet David , Papageorgiou Kostas A. , Johnston Matthew , Bilello Delfina , Patterson Aaron , Alderdice Fiona 
Published: March 2021

Abstract
Background
Very premature birth (gestational age between 28 and 31 + 6 weeks) is associated with increased risk of cognitive delay and attention deficit disorder, which have been linked to anomalies in the development of executive functions (EFs) and their precursors. In particular, very preterm (VP) infants display anomalies in controlling attention and gathering task-relevant information. Early interventions that support attention control may be pivotal in providing a secure base for VP children’s later attainments. The Attention Control Training (ACT) is a cognitive training intervention that targets infants’ abilities to select visual information according to varying task demands but had not been tested in VP infants. We conducted a feasibility study to test the processes we intend to use in a trial delivering the ACT to VP infants.

Methods and design
We tested recruitment and retention of VP infants and their families in a randomised trial, as well as acceptability and completion of baseline and outcome measures. To evaluate these aims, we used descriptive quantitative statistics and qualitative methods to analyse feedback from infants’ caregivers. We also investigated the quality of eye-tracking data collected and indicators of infants’ engagement in the training, using descriptive statistics.

Results
Twelve VP infants were recruited, and 10 (83%) completed the study. Participants’ parents had high education attainment. The rate of completion of baseline and outcome measures was optimal. VP infants demonstrated engagement in the training, completing on average 84 min of training over three visits, and displaying improved performance during this training. Eye-tracking data quality was moderate, but this did not interfere with infants’ engagement in the training.

Discussion
The results suggest the ACT can be delivered to VP infants. However, challenges remain in recruitment of numerous and diverse samples. We discuss strategies to overcome these challenges informed by results of this study.

Trial registration
Registered Registration ID: NCT03896490. Retrospectively registered at Clinical Trials Protocol Registration and Results System (clinicaltrials.gov).
The effect of expertise, target usefulness and image structure on visual search
Authors: Robson Samuel G. , Tangen Jason M. , Searston Rachel A. 
Published: March 2021

AbstractExperts outperform novices on many cognitive and perceptual tasks. Extensive training has tuned experts to the most relevant information in their specific domain, allowing them to make decisions quickly and accurately. We compared a group of fingerprint examiners to a group of novices on their ability to search for information in fingerprints across two experiments—one where participants searched for target features within a single fingerprint and another where they searched for points of difference between two fingerprints. In both experiments, we also varied how useful the target feature was and whether participants searched for these targets in a typical fingerprint or one that had been scrambled. Experts more efficiently located targets when searching for them in intact but not scrambled fingerprints. In Experiment 1, we also found that experts more efficiently located target features classified as more useful compared to novices, but this expert-novice difference was not present when the target feature was classified as less useful. The usefulness of the target may therefore have influenced the search strategies that participants used, and the visual search advantages that experts display appear to depend on their vast experience with visual regularity in fingerprints. These results align with a domain-specific account of expertise and suggest that perceptual training ought to involve learning to attend to task-critical features.
Neurological symptoms in COVID-19: a cross-sectional monocentric study of hospitalized patients
Authors: Ermis Ummehan , Rust Marcus Immanuel , Bungenberg Julia , Costa Ana , Dreher Michael , Balfanz Paul , Marx Gernot , Wiesmann Martin , Reetz Kathrin , Tauber Simone C. , Schulz Jörg B. 
Published: March 2021

Abstract
Background
The SARS-Coronavirus-2 (SARS-CoV-2) invades the respiratory system, causing acute and sometimes severe pulmonary symptoms, but turned out to also act multisystematically with substantial impact on the brain. A growing number of studies suggests a diverse spectrum of neurological manifestations. To investigate the spectrum of symptoms, we here describe the neurological manifestations and complications of patients with proven SARS-CoV-2 infection who have been hospitalized at the RWTH University Hospital Aachen, Germany.

Methods
Between March and September 2020, we evaluated common symptoms, clinical characteristics, laboratory (including cerebrospinal fluid (CSF) analysis), radiological, and electroencephalography (EEG) data from 53 patients admitted with a positive SARS-CoV-2 polymerase chain reaction (PCR). We used the Montreal Cognitive Assessment Test (MoCA) to screen for cognitive impairment, when feasible. We compared critically ill and non-critically ill patients categorized according to the presence of Acute Respiratory Distress Syndrome (ARDS).

Results
Major clinical neurological features of hospitalized COVID-19 patients were coordination deficits (74%), cognitive impairment (61.5%), paresis (47%), abnormal reflex status (45%), sensory abnormalities (45%), general muscle weakness and pain (32%), hyposmia (26%), and headache (21%). Patients with ARDS were more severely affected than non-ADRS patients. 29.6% of patients with ARDS presented with subarachnoid bleedings, and 11.1% showed ischemic stroke associated with SARS-CoV-2 infection. Cognitive deficits mainly affected executive functions, attention, language, and delayed memory recall. We obtained cerebrospinal fluid (CSF) by lumbar puncture in nine of the 53 patients, none of which had a positive SARS-CoV-2 PCR.

Conclusions
In line with previous findings, our results provide evidence for a range of SARS-CoV-2-associated neurological manifestations. 26% of patients reported hyposmia, emphasizing the neuro-invasive potential of SARS-CoV-2, which can enter the olfactory bulb. It can therefore be speculated that neurological manifestations may be caused by direct invasion of the virus in the CNS; however, PCR did not reveal positive intrathecal SARS-CoV-2. Therefore, we hypothesize it is more likely that the para-infectious severe pro-inflammatory impact of COVID-19 is responsible for the neurological deficits including cognitive impairment. Future studies with comprehensive longitudinal assessment of neurological deficits are required to determine potential long-term complications of COVID-19.
O wyzwaniach, przed jakimi staje tłumacz literatury dla dzieci
Authors: Manasterska-Wiącek Edyta 
Published: March 2021

On Challenges Faced by Translators of Children’s Literature
The aim of the article was to investigate the effect of the translation solutions applied in the Polish translation of V. Garshin’s Lyagushka-puteshestvennica fable on the child addressee. The article starts with an overview of characteristic features of text recipient (prior knowledge, attitudes and values, limited bilingualism and biculturalism), referring them to the childad dressee with the consideration of readers belonging to different cultures. Due to limited knowledge and awareness of children (as compared to the adult reader), the linguistic solutions applied in the translation acquire a different perspective – they are closely connected with the recognition of the known and the unknown by the child, regardless of one’s own culture.The analysis shows that the differences in the precision of rendering the cognitive and emotional value of the text as well as disregarding key elements of the original text by the translator can easily distort the reception of the investigated text by the child recipient.
Contributing factors on students’ willingness to communicate (WTC)
Authors: Susanti Elis 
Published: March 2021

One of the non-linguistics factors which is sometimes out of the teacher’s awareness during the teaching of speaking is how ready or how willing the language learners are to engage in the provided activities in which this psychological condition is then termed as Willingness to Communicate (WTC). To prepare the language learners in order to be more ready or willing is essential to take into account since a fact shows that the high WTC will increase the language learners’ frequency of using the language learned (English) in a communication. This is a descriptive qualitative research which investigated about the students’ WTC in a speaking class consisting of 29 students English Department in STKIP Muhammadiyah Kotabumi. Apart from this, this study also probed what variables influencing their WTC. An observation was done in order to collect the research data and make a conclusion. Due to the collecting data, it was found that students’ WTC is high. Further, some variables such as classroom variables (task type, topic, and interlocutor), individual variables (introversion, self-esteem, and anxiety), and communicative competence are found to contribute on students’ WTC during the speaking activity. Among others, the topic given is as the most influential variable affects students’ WTC. Whereas, it is found that interlocutor variable due to their gender and age does not affect students’ WTC. Hence, English teachers are suggested to give more attention at some variables affecting students’ WTC in order to help the students increase their WTC which leads to their speaking improvement.
Single-shot spatial coherence characterization of x-ray ultrafast sources
Authors: Duarte Joana , Gonzalez Aura Inés , Cassin Rémy , Nicolas Rana , Kholodstova Maria , Boutu Willem , Fajardo Marta , Merdji Hamed 
Published: March 2021

Spatial coherence is an impactful source parameter in many applications ranging from atomic and molecular physics to metrology or imaging. In lensless imaging, for example, it can strongly affect the image formation, especially when the source exhibits shot-to-shot variations. Single-shot characterization of the spatial coherence length of a source is thus crucial. However, current techniques require either parallel intensity measurements or the use of several masks. Based on the method proposed by González et al. [J. Opt. Soc. Am. A 28, 1107 (2011)JOAOD60740-323210.1364/JOSAA.28.001107], we designed a specific arrangement of a two-dimensional non-redundant array of apertures, which allows, through its far field interference pattern, for a single-shot measurement of the spatial coherence, while being robust against beam-pointing instabilities. The strategic configuration of the pinholes allows us to disentangle the degree of spatial coherence from the intensity distribution, thus removing the need for parallel measurement of the beam intensity. An experimental validation is performed using a high-harmonic source. A statistical study in different regimes shows the robustness of the method.
Serum levels of circulating microRNA-107 are elevated in patients with early-stage HCC
Authors: Loosen Sven H. , Castoldi Mirco , Jördens Markus S. , Roy Sanchary , Vucur Mihael , Kandler Jennis , Hammerich Linda , Mohr Raphael , Tacke Frank , Ulmer Tom F. , Neumann Ulf P. , Luedde Tom , Roderburg Christoph 
Published: March 2021

Background
Early detection of hepatocellular carcinoma (HCC), the most common primary liver malignancy, is crucial to offer patients a potentially curative treatment strategy such as surgical resection or liver transplantation (LT). However, easily accessible biomarkers facilitating an early diagnosis of HCC as well as a reliable risk prediction are currently missing. The microRNA(miR)-107 has recently been described as a driver of HCC in both murine and human HCC but data on circulating miR-107 in HCC patients are scarce. In the present study, we evaluated a potential diagnostic and/or prognostic role of circulating miR-107 in patients undergoing tumor resection or LT for early-stage HCC.

Methods
The Kmplot bioinformatic tool was used to query publicly available databases (including TCGA, GEO and EGA) in order to analyse the prognostic value of tumoral miR-107 expression in HCC patients (n = 372). Serum levels of miR-107 were measured by qPCR in n = 45 HCC patients undergoing surgical tumor resection (n = 37) or LT (n = 8) as well as n = 18 healthy control samples. Results were correlated with clinical data.

Results
A high tumoral expression of miR-107 was associated with a significantly better overall survival compared to patients with low miR-107 expression levels (HR 0.69, 95% CI 0.48–0.99, p = 0.041). In addition, serum levels of miR-107 were significantly higher in HCC patients when compared to healthy controls. However, miR-107 serum levels in HCC patients were independent of different disease etiology, tumor stage or tumor grading. HCC patients with baseline miR-107 expression levels above a calculated ideal prognostic cut-off value (9.82) showed a clear trend towards an impaired overall survival (p = 0.119).

Conclusion
Tumoral miR-107 expression levels are a potential prognostic marker in early stage HCC. Furthermore, we describe a potential role of circulating miR-107 levels as a diagnostic biomarker in patients with early-stage HCC.
Understanding variations and influencing factors on length of stay for T2DM patients based on a multilevel model
Authors: Liu Wen , Shi Jingcheng , He Simin , Luo Xi , Zhong Weijun , Yang Fang 
Published: March 2021

Aim
Shortening the length of stay (LOS) is a potential and sustainable way to relieve the pressure that type 2 diabetes mellitus (T2DM) patients placed on the public health system.

Method
Multi-stage random sampling was used to obtain qualified hospitals and electronic medical records for patients discharged with T2DM in 2018. A box-cox transformation was adopted to normalize LOS. Multilevel model was used to verify hospital cluster effect on LOS variations and screen potential factors for LOS variations from both individual and hospital levels.

Result
50 hospitals and a total of 12,888 T2DM patients were included. Significant differences in LOS variations between hospitals, and a hospital cluster effect on LOS variations (t = 92.188, P<0.001) was detected. The results showed that female patients, patients with new rural cooperative’ medical insurance, hospitals with more beds, and hospitals with faster bed turnovers had shorter LOS. Conversely, elderly patients, patients with urban workers’ medical insurance, patients requiring surgery, patients with the International Classification of Diseases coded complication types E11.1, E11.2, E11.4, E11.5, and other complications cardiovascular diseases, grade III hospitals, hospitals with a lower doctor-to-nurse ratio, and hospitals with more daily visits per doctor had longer LOS.

Conclusions
The evidence proved that hospital cluster effect on LOS variation did exist. Complications and patients features at individual level, as well as organization and resource characteristics at hospital level, had impacted LOS variations to varying degrees. To shorten LOS and better meet the medical demand for T2DM patients, limited health resources must be allocated and utilized rationally at hospital level, and the patients with the characteristics of longer LOS risk must be identified in time. More influencing factors on LOS variations at different levels are still worth of comprehensive exploration in the future.
Troponin elevation pattern and subsequent cardiac and non-cardiac outcomes: Implementing the Fourth Universal Definition of Myocardial Infarction and high-sensitivity troponin at a population level
Authors: Chuang Anthony (Ming-yu) , Nguyen Mau T. , Khan Ehsan , Jones Dylan , Horsfall Matthew , Lehman Sam , Smilowitz Nathaniel R. , Lambrakis Kristina , Than Martin , Vaile Julian , Sinhal Ajay , French John K. , Chew Derek P. 
Published: March 2021

Background
The Fourth Universal Definition of Myocardial Infarction (MI) differentiates MI from myocardial injury. We characterised the temporal course of cardiac and non-cardiac outcomes associated with MI, acute and chronic myocardial injury.

Methods
We included all patients presenting to public emergency departments in South Australia between June 2011–Sept 2019. Episodes of care (EOCs) were classified into 5 groups based on high-sensitivity troponin-T (hs-cTnT) and diagnostic codes: 1) Acute MI [rise/fall in hs-cTnT and primary diagnosis of acute coronary syndrome], 2) Acute myocardial injury with coronary artery disease (CAD) [rise/fall in hs-cTnT and diagnosis of CAD], 3) Acute myocardial injury without CAD [rise/fall in hs-cTnT without diagnosis of CAD], 4) Chronic myocardial injury [elevated hs-cTnT without rise/fall], and 5) No myocardial injury. Multivariable flexible parametric models were used to characterize the temporal hazard of death, MI, heart failure (HF), and ventricular arrhythmia.

Results
372,310 EOCs (218,878 individuals) were included: acute MI (19,052 [5.12%]), acute myocardial injury with CAD (6,928 [1.86%]), acute myocardial injury without CAD (32,231 [8.66%]), chronic myocardial injury (55,056 [14.79%]), and no myocardial injury (259,043 [69.58%]). We observed an early hazard of MI and HF after acute MI and acute myocardial injury with CAD. In contrast, subsequent MI risk was lower and more constant in patients with acute injury without CAD or chronic injury. All patterns of myocardial injury were associated with significantly higher risk of all-cause mortality and ventricular arrhythmia.

Conclusions
Different patterns of myocardial injury were associated with divergent profiles of subsequent cardiac and non-cardiac risk. The therapeutic approach and modifiability of such excess risks require further research.
Association between dementia and systemic rheumatic disease: A nationwide population-based study
Authors: Park Hyemi , Yim Dong-hyuk , Ochirpurev Bolormaa , Eom Sang-Yong , Choi In Ah , Ju Gawon , Kim Ji Hyoun 
Published: March 2021

Objectives
Systemic rheumatic disease is characterized by autoimmunity and systemic inflammation and affects multiple organs. Few studies have investigated whether autoimmune diseases increase the risk of dementia. Herein, we evaluate the relationship between systemic rheumatic disease and dementia through a population-based study using the Korean National Health Insurance Service (NHIS) claims database.

Methods
We conducted a nationwide population-based study using the Korean NHIS database, consisting of individuals who submitted medical claims from 2002–2013. Dementia was defined as having an acetylcholinesterase inhibitors (AChEIs) prescription along with symptoms satisfying the Alzhemier’s disease (AD) International Classification of Diseases (ICD)-10 codes (F00 or G30), or vascular dementia (VaD; ICD-10 or F01) criteria. Control subjects were matched to the dementia patients by age and sex. The study group was limited to those diagnosed with rheumatic disease at least 6 months prior to diagnosis of dementia. Rheumatic disease was defined by the following ICD-10 codes: Rheumatoid arthritis (RA: M05), Sjögren’s syndrome (SS: M35), systemic lupus erythematosus (SLE: M32), and Behcet’s disease (BD: M35.2).

Results
Of the 6,028 dementia patients, 261 (4.3%) had RA, 108 (1.6%) had SS, 12 (0.2%) had SLE, and 6 (0.1%) had BD. SLE history was significantly higher in dementia patients (0.2%) than in controls (0.1%) and was associated with dementia (odds ratio [OR], 2.48; 95% confidence interval [CI], 1.19–5.15). In subgroup analysis, SLE significantly increased dementia risk, regardless of dementia type (AD: OR, 2.29; 95% CI, 1.06–4.91; VaD: OR, 4.54; 95% CI, 1.36–15.14). However, these associations were not sustained in the mild CCI or elderly group.

Conclusion
SLE was independently associated with a higher risk of dementia, including AD and VaD when compared to the control group, even after adjustment. SLE patients (<65 years old) are a high-risk group for early vascular dementia and require screening for early detection and active prevention.