bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nitrophenyl-group-containing Heterocycles. 3. New Isoquinolines, as antiprolifative agents against MCF7and HEGP2 Cell lines. Synthesis, characterization and biological Evaluation.
Authors: Bakhite Etify A. , Hassanien Reda , Farhan Nasser , Sayed Eman M. , Sharaky Marwa 
Published: December 2024

Abstract

In this study, new tetrahydrosoquinoline compounds were synthesized by reacted with methyl iodide, chloro acetonitrile, ethyl chloroacetate, N-arylchloroacetamides N-and (benzthiazol-2-yl)-2-chloroacetamide reagents to gave tetrahydroiso-quinolin-3-ylthio) acetamides (5a-c) which can cyclized to tetrahydroiso-quinolin-3-ylthio) acetamides (6a-c) in excellent yields. The structures of all newly synthesized compounds were characterized by elemental and spectral analyses. Also, most of the synthesized compounds were evaluated for their anticancer activity in MCF7 and HEPG2 cell lines. From the result we found that the most potent compound against the MCF7 cell lines was compound 9b, and the most active against HEPG2 cell lines was compound 3. Then the effects of compound 3 on the HEPG2 cell line was investigated using an apoptotic Annexin V-FITC test and flow cytometry. Compound 3 induced a 59-fold increase in HEPG2 cell line apoptosis and cell cycle arrested at the G0-G1, G2/M phases. Moreover, the molecular docking study was applied and the result showed that compounds 9b bind to the RET enzyme with binding energies of -6.8 kcal/mol in comparison with standard alectinib, which exhibits a binding energy of -7.2 kcal/mol. Compound 3 can bind with HSP 90 with a binding energy (ΔG) of -6.8 kcal/mol, which is comparable to the standard Onalespib (-7.1 kcal/mol).
Gray and White Matter Microstructural Alterations in Major Depressive Disorder: A Multi-Center Diffusion Imaging Study
Authors: Murai Toshiya , Takahashi Kento , Suwa Taro , Yoshihara Yujiro , Kyuragi Yusuke , Oishi Naoya , Takano Harumasa , Noda Takamasa , Hirano Jinichi , Hatakoshi Momoko , Ishikawa Yuzuki , Miyata Jun , Igarashi Hiroyuki , Kanno Hiroyuki , Murakami Shingo , Mimura Masaru , Nakagome Kazuyuki 
Published: December 2024

Abstract

Alterations in gray matter (GM) and white matter (WM) microstructure have been implicated in the pathophysiology of major depressive disorder (MDD). While previous neuroimaging studies have primarily focused on WM microstructural changes, limited attention has been given to GM alterations. Additionally, many of these studies concentrate on region-specific associations with symptoms rather than a comprehensive assessment of broader microstructural changes. In this study, we employed neurite orientation dispersion and density imaging (NODDI) and diffusion tensor imaging (DTI) to investigate GM and WM microstructural changes at both whole-brain and regional levels. Data were collected from 159 MDD patients and 112 healthy controls across multiple centers. Our findings revealed significantly increased mean free water fraction (FWF) in GM, elevated mean orientation dispersion index (ODI) in WM, and decreased fractional anisotropy (FA) in WM among MDD patients compared to healthy controls. Furthermore, the mean FA of WM exhibited a negative correlation, and the mean ODI of WM showed a positive correlation with illness duration. No significant correlations were observed between diffusion indices and Hamilton Depression Rating Scale (HAMD-17) scores. Gray matter-based spatial statistics demonstrated increased FWF in several GM regions, including the frontal lobes, temporal lobes, and limbic system. Tract-based spatial statistics revealed widespread reductions in FA across WM in MDD patients. These findings suggest that neuroinflammation and myelin abnormalities may underlie the observed microstructural changes, emphasizing the need for future research to link neuroimaging findings with underlying biological mechanisms of MDD.
Translation and validation of the meat attachment questionnaire (MAQ) in a French General Practice Population
Authors: Delaunay Bruno , Tudrej Benoit , Bernard Augustin , Dupuy Alexandra , Malavergne Claire , Bacon Trystan , Sebo Paul , Maisonneuve Hubert 
Published: December 2024

Abstract

Background
Meat consumption has significant implications for both individual health and the environment. Understanding individuals' attachment to meat is crucial for designing effective interventions to reduce consumption. The MAQ is a tool developed to assess individuals' attachment to meat.
Objective
This study aims to translate and validate the MAQ into French for use in a general practice population in France.
Methods
The study was conducted in three phases: translation, pretesting through cognitive interviews, and testing through a cross-sectional study of general practice patients. Descriptive, factorial, and internal consistency analyses were performed to validate the French version of the MAQ.
Results
The French version of the MAQ consists of 17 items in four dimensions: Hedonism, Affinity, Entitlement, and Dependence. Face validity was confirmed by cognitive interviews. The RMSEA and CFI were 0.06 and 0.92 respectively, showing acceptable goodness-of-fit. Internal consistency was demonstrated with Cronbach's alpha and Loevinger's H coefficients exceeding 0.7 and 0.3, respectively.
Conclusions
The French version of the MAQ is a valid and reliable tool for assessing individuals' attachment to meat in a general practice population. Its application shows promise for the design of targeted interventions to reduce meat consumption, benefiting both individual health and environmental sustainability.
Impact of Social Exclusion on salivary Progesterone and Estradiol in Women with Borderline Personality Disorder
Authors: Barthauer Marie , Graumann Livia , Cho An Bin , Kulakova Eugenia , Deuter Christian Eric , Wolf Oliver T. , Hellmann-Regen Julian , Roepke Stefan , Otte Christian , Wingenfeld Katja 
Published: December 2024

Abstract

Background
Borderline personality disorder (BPD) is characterized by instability in interpersonal relationships and fear of abandonment, which intensify during stress. Social stressors seem to activate the hypothalamic–pituitary–gonadal (HPG) axis in healthy controls (HC), but this has not been investigated in patients with BPD. This study aimed to investigate the effects of social stress, i.e. social exclusion on progesterone and estradiol levels in women with BPD compared to HC.
Methods
82 women with BPD and 82 HC were randomly assigned to either an exclusion or overinclusion condition of the Cyberball paradigm. Saliva samples were collected at baseline and 15 minutes after the task to measure progesterone and estradiol. Two 2 × 2 factorial ANOVAs were conducted with group and condition as the independent variables and Δ-progesterone and Δ-estradiol as dependent variables.
Results
On progesterone, the analysis revealed no significant main effects of group or condition, but a significant group × condition interaction. Post-hoc tests showed that progesterone responses within the BPD group significantly differed between exclusion and overinclusion, while no significant differences were observed in HC. Descriptively, progesterone levels increased following social exclusion, whereas they decreased after overinclusion in BPD. For estradiol levels no significant main effects for group, condition, or their interaction were found.
Discussion
This study provides initial evidence that women with BPD exhibit distinct progesterone responses to social exclusion versus overinclusion. BPD participants showed a descriptive decrease in progesterone after overinclusion and a small increase after exclusion. These findings might be interpreted as perhaps a lack of assumed protective effects of progesterone (e.g. calming). Further research is needed to better understand this hormonal pattern and its implications for social functioning in BPD.
Clinical Efficacy, Safety, and Success Factors of Botulinum Toxin Type A in the Treatment of Acute Acquired Comitant Esotropia
Authors: Ui Makiko , Goseki Toshiaki , Watanabe Ayumi , Fueki Kinue , Komiya Yuko , Yamamoto Risako , Tsutsumi Noriko , Yoshida Hiroki 
Published: December 2024

Abstract

Acute acquired comitant esotropia (AACE) is an increasingly reported form of esotropia, possibly linked to the rising use of digital devices. Botulinum toxin type A (BTXA) has emerged as a minimally invasive treatment alternative to surgery, particularly for patients who present with diplopia. This study retrospectively evaluated 228 patients with AACE who received BTXA injections at a single center. Treatment outcomes, adverse events, and factors influencing success were analyzed. The average patient age was 30.9 years, and 57% achieved successful outcomes, with 46% being cured and 11% showing improvement. Transient adverse events, including ptosis (24%) and hypertropia (16%), were observed. The study found that shorter duration from onset to treatment (P = 0.024) and post-treatment overcorrection (P = 0.001) were associated with higher success rates. Although some patients required additional treatments or surgery due to recurrence, BTXA proved to be an effective intervention for AACE, with a significant improvement in eye alignment and stereopsis. These findings suggest that early intervention with BTXA is crucial for successful outcomes and offers a safe, less invasive alternative to traditional strabismus surgery.
Unraveling the role of adjuvant chemotherapy in elderly triple-negative breast cancer: Insights from competing risk analysis using SEER data
Authors: Ziqiang Wang , Tingting Wang , Yangyang Xie , Xiaowen Li , Danwei Du , Rongguo Li 
Published: December 2024

Abstract

Background
Triple-negative breast cancer (TNBC) is an aggressive subtype with poor outcomes, particularly in elderly patients. Chemotherapy remains the primary systemic treatment, but its effectiveness in TNBC patients aged 70 years and older remains controversial due to comorbidities and poor treatment tolerance. This study evaluates the survival impact of adjuvant chemotherapy in this population using a competing risk analysis.
Methods
A retrospective cohort of 4,855 elderly TNBC patients (≥70 years) was extracted from the SEER database (1995–2016). Propensity score matching (PSM) was applied to balance baseline characteristics between chemotherapy and non-chemotherapy groups. Overall survival (OS), cancer-specific survival (CSS), and competing risks of cancer-specific death (CSD) and other-cause death (OCD) were analyzed using Kaplan-Meier and Fine-Gray subdistribution proportional hazards models. A competing risk-based nomogram was developed to predict individualized survival outcomes.
Results
After PSM, the chemotherapy group showed significantly improved OS (p < 0.05), but no significant difference in 5-year CSD (16.88% vs. 19.01%, p = 0.1664). However, chemotherapy reduced the 5-year cumulative incidence of OCD (8.93% vs. 18.55%, p < 0.001). Multivariate competing risk analysis identified marital status, tumor grade, receipt of radiation therapy, T stage, and N stage as independent predictors of CSD. The nomogram incorporating these factors demonstrated high predictive accuracy (AUC: 1-year = 0.788, 3-year = 0.768, 5-year = 0.747) and excellent calibration.
Conclusion
Adjuvant chemotherapy provides limited direct benefit in reducing CSD but significantly decreases OCD in elderly TNBC patients, improving OS. The competing risk analysis offers a comprehensive understanding of mortality risks and underscores the value of individualized treatment. The validated nomogram supports precision medicine approaches for this high-risk population. Future studies should address underlying biological mechanisms and validate findings in multi-regional cohorts.
Application of acupuncture combined with ultrasound-guided thoracic paravertebral nerve block in thoracoscopic surgery for lung cancer: A Randomised Controlled Trial
Authors: Ding Longfei , Xu Xuan , Liu Jie , Wang Beiru , Wu Caineng 
Published: December 2024

Abstract

Background
Patients undergoing thoracoscopic lung cancer surgery often undergo ultrasound-guided thoracic paravertebral block before surgery, but adverse effects such as hypotension and bradycardia often occur after the block. The purpose of this study is to evaluate the hypothesis that electroacupuncture is effective in treating hypotension and bradycardia after ultrasound-guided thoracic paravertebral block.
METHODS
Adult patients scheduled to undergo thoracoscopic lung cancer surgery were randomly assigned to the electroacupuncture group and the control group after undergoing ultrasound-guided thoracic paravertebral block. In the intervention group, electroacupuncture treatment was started at the Neiguan (PC6) and the Zu Sanli (ST36) acupoints 30 minutes before the procedure and continued until the end. Patients in the control group received the same electroacupuncture treatment at non-acupuncture points (near PC6 and ST36). The primary outcome of this trial was the incidence of hypotension after thoracic paraspinal block.
Results
The incidence of hypotension after ultrasound-guided thoracic paravertebral block was lower in the EA group compared to the control group: 22(56.4%) vs 7(17.9%), P < 0.01. The incidence of bradycardia in the EA group was also reduced: 12(30.8%) vs 3(7.7%), P = 0.01.
Conclusions
Perioperative EA treatment can effectively reduce the incidence of hypotension and bradycardia after ultrasound-guided thoracic paravertebral block in patients undergoing thoracoscopic lung cancer surgery.
Trial registration:
This study has been registered with the Chinese Clinical Registry (http://www.chictr.org.cn/index.aspx) under the trial identifier number ChiCTR2300077984 with a registration date of 27 November 2023.
Multicenter epidemiological investigation and analysis of factors associated with transient synovitis of the hip in 5065 children treated across 32 tertiary children’s hospitals in China
Authors: Chen Jianlin , Deng Hansheng , Feng Haoran , Zhu Tianfeng , Huang Zilong , Li Jiahui , Wang Xinyu , Liu Gen , Liu Shizhe , Wang Shuaiyin , Gu Zhenkun , Feng Guoshuang , Caggiari Gianfilippo , You Chao , Qiu Xin , Fu Guibing 
Published: December 2024

Abstract

Purpose
This study analyzes the demographic information, concurrent infectious diseases, treatment methods, and hospitalization costs for children with transient synovitis of the hip (TSH) in China and to provide a scientific basis for its early diagnosis, treatment decisions, and preventive measures.
Methods
We retrospectively analyzed the data of children with TSH who were hospitalized across 32 pediatric tertiary hospitals affiliated with China’s Futang Research Center of Pediatric Development between December 1, 2015, and December 31, 2022. We used the ICD10 codes on the first page of the medical records to identify the cases and extracted data on age, sex, diagnosis, concurrent infectious diseases, treatment methods, season of treatment, region, and various expenses incurred during hospitalization.
Results
The study cohort comprised a total of 5065 children, including 3711 males and 1354 females. The age group with the highest number of TSH cases was the preschool children group, with 2452 cases (48.4%), and the lowest number of cases was recorded in the adolescent group, with 119 cases (2.3%). In terms of hospitalization time, the adolescent group had the longest average hospitalization time of 9.4 ± 5.6 days. In terms of the distribution of onset time, the largest proportion of TSH cases was recorded in winter (26.52%), and the smallest proportion, in spring (23.06%). In terms of the geographical distribution of onset, the number of cases in East China was higher than that in other geographical regions. In addition, among the 5065 children included, 16.7% had infectious diseases, of which respiratory tract infections accounted for the largest proportion (92.6%), followed by gastrointestinal infections (3.0%). In terms of treatment options, children were more likely to receive conservative treatment (7,667 instances) than surgical treatment (80 instances). Among conservative treatments, the most common was skin traction (4,508 instances). Among the various hospitalization expenses, the cost of examinations was the highest, reaching RMB 1,312(Renminbi, China's official currency).
Conclusion
This study provides important clinical data supporting the epidemiological characteristics and treatment of children with TSH in China and provides a scientific basis for strengthening the prevention, diagnosis, management, and treatment of the disease that could help reduce the public health burden posed by TSH and optimize the treatment process.
Research on luminaire paint defect detection model based on improved YOLOv10
Authors: Wu Dengtao , Yang Likang 
Published: December 2024

Abstract

Aiming at the problems of low detection accuracy, low computational efficiency and poor detection ability of multi-scale targets in existing detection methods, an improved YOLOv10 algorithm was proposed to improve the accuracy and efficiency of multi-scale defect detection of luminaire paint. By introducing the LSKA attention mechanism to the SPPF module on the YOLOv10 feature extraction backbone network, the recognition ability of the complex form of paint defects of lamps is improved. At the same time, the lightweight design of C2f and detection head module makes the algorithm more suitable for real-time application scenarios. In terms of evaluation indexes, after ablation experiments, the improved algorithm has improved 2.6% compared with the original YOLOv10 in main performance indexes mAP@0.5. In addition, the lightweight design of the improved algorithm significantly reduces the number of parameters and the amount of computation required. Compared with the original YOLOv10, the number of parameters is reduced by 0.22×106 and the amount of computation is reduced by 1.4GFLOPS, making it more suitable for deployment in resource-constrained environments. The improved YOLOv10 algorithm proposed in this paper achieves a balance of high accuracy and high efficiency in the multi-scale defect detection of luminaire paint surface, providing a reliable machine learning technical means for industrial production, and helping industrial equipment to carry out efficient monitoring and diagnosis under unattended conditions.
Treatment Failure in Non-Intubated Acute Respiratory Distress Syndrome: A Retrospective Cohort Study
Authors: Kim Kyung Hoon , Yoon Joo Heung , Kim Seok Chan , Lee Jongmin 
Published: December 2024

Abstract

Background
Acute respiratory distress syndrome (ARDS) is a severe respiratory condition associated with high mortality, traditionally requiring invasive mechanical ventilation. However, the recent global redefinition of ARDS now encompasses non-intubated patients receiving high-flow nasal oxygen (HFNO) or non-invasive positive pressure ventilation (NIPPV), emphasizing the need for non-invasive management strategies. Despite their widespread use, the factors contributing to treatment failure in these modalities remain poorly understood. The aim of this study was to analyse the characteristics related to the treatment failure of HFNO and NIPPV in patients who met the new global definition of non-intubated ARDS.
Methods
Patients who satisfied the newly defined criteria for non-intubated ARDS receiving HFNO or NIPPV were included in the MIMIC-IV database. Clinical characteristics and parameters were analysed, including respiratory rate–oxygenation (ROX) value at 1, 6, and 12 h after applying HFNO or NIPPV. Of the 238 patients, 114 and 124 received HFNO and NIPPV, respectively.
Results
In the HFNO group, the ROX value 1 h after application was significantly lower in patients with treatment failure (AUROC 0.702, cut-off value 4.059). In the NIPPV group, the ROX values at 1, 6, and 12 h were significantly lower in patients with treatment failure. However, only that at 12 h was consistent (AUROC 0.696, cut-off 7.827) after adjusting for confounders. The ROX index demonstrated its utility in predicting treatment failure in non-intubated ARDS, with the timing of assessment varying based on the respiratory support modality. For HFNO, the ROX index at 1 h was the most predictive, whereas, for NIPPV, the ROX index at 12 h showed the strongest association with treatment failure.
Conclusions
These findings underscore the importance of tailored monitoring strategies based on the type of respiratory support provided.
Mandatory verses voluntary self-tests for new online casino customers – effect on engagement, quality, gambling behavior and use of responsible gambling measures.
Authors: Jonsson Jakob , Lakew Nathan , Lindner Philip 
Published: December 2024

Abstract

Background: To combat the public health concern that is problem gambling, gambling operators are increasingly being required by legislation to exercise a duty of care obligation, including the provision of Responsible Gambling (RG) tools. Self-test assessments have long been a popular RG tool implemented by many operators, yet there has been scant empirical research on self-tests, including on how the method of delivery impacts engagement, quality, and subsequent gambling behavior. The main objective of the current study was to examine if the level of voluntariness to perform a self-test moderated these key outcomes.
Method. Participants in the study, 1,800 new online customers at a leading Swedish gambling company, were randomized to one of three arms: No message (control), up to four messages inviting them to do a self-test, and one message with a mandatory (but technically possible to circumvent) self-test. The interventions were presented when the customer logged in.
Results: The results showed that 38.9% in the mandatory group and 4.8% in the voluntary group completed the self-test, with indications of a somewhat lower quality of the test by the mandatory group. There was no difference in customer churn or gambling behavior, and only minor differences in use of RG-measures post intervention.
Conclusions. We conclude that presentation format matters and can affect the use and quality of tests:gambling operators should exercise caution when interpreting non-risk assessment results derived solely from self-test tools, particularly mandatory ones, as it can result in inaccurate risk assessments that may mislead duty of care obligations. The balance between achieving high participation and maintaining quality (and thereby meaningfulness) is discussed.