bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arclogites in the Subarc Lower Crust: Effects of Crystallization, Partial Melting, and Retained Melt on the Foundering Ability of Residual Roots
Authors: Bowman Emilie E , Ducea Mihai N , Triantafyllou Antoine 
Published: November 2021

ABSTRACTThick-crusted (&gt;45 km) Cordilleran arcs exhibit cyclic processes including periods of magmatic quiescence interspersed with pulses of high-flux magmatism. Most models assume that during high-flux events, fractional crystallization and partial melting within the deep crustal hot zone generate a dense (&gt;3.4 g/cm3) arclogitic subarc root that can readily founder into the mantle. Yet these models do not consider that: (1) the retention of low-density melt within the subarc root, and (2) the protolith lithology of the restitic portion of the subarc root may greatly impact the density evolution of the root and its susceptibility to foundering. In this article, we first address the effect of retained melt on the foundering ability of the subarc root by calculating the density and time for foundering of melt-bearing arclogitic residue at 1.5, 2, and 2.5 GPa. We find that melt volumes &gt;10–18% are required to stabilize the root within the lower crust; melt volumes below this threshold lower the viscosity of the residue so much so as to decrease the time for foundering by an order of magnitude. We then constrain through phase equilibria modeling the effect of partial melting of different lower crustal protoliths on the density of the restitic subarc root. To do this, we model the density and mineralogical evolution of restites in equilibrium with their derivative melts during open-system, isobaric partial melting of typical crustal assemblages from 600–1100°C at 1.5 (~50 km) and 2 GPa (~65 km). In our models, typical end-member assemblages in a lower crustal hot zone include basalt, metapelite, and metagraywacke. We find that melt-depleted restites derived from basaltic compositions are amphibole-bearing arclogites with densities conducive to foundering, which at 2 GPa can occur even in the presence of the coexisting hydrous felsic residual melt. Foundering of the amphibole ± melt-bearing root may refertilize the mantle wedge and induce melting of the surrounding asthenosphere as well as the arclogitic mass. However, if temperatures in a 50-km deep subarc hot zone are not sufficient to drive melt depletion of basaltic restites, these dense (3.1–3.3 g/cm3) residues are gravitationally stable, increasing the density of the lower crust and lowering the elevation of the arc. In comparison, partial melting of metasedimentary country rock produces alkali feldspar-rich residues that never achieve densities conducive to foundering. Thus, if high-flux events are driven by the influx of melt-fertile lithosphere beneath the arc as envisioned by the Cordilleran cycle model, then partial melting of the metasedimentary portion will generate low-density residues that remain in the lower crust and contribute to the thickness, geochemistry, and seismic structure of the bulk arc.
The evolutionarily conserved kinase SnRK1 orchestrates resource mobilization during Arabidopsis seedling establishment
Authors: Henninger Markus , Pedrotti Lorenzo , Krischke Markus , Draken Jan , Wildenhain Theresa , Fekete Agnes , Rolland Filip , Müller Martin J , Fröschel Christian , Weiste Christoph , Dröge-Laser Wolfgang 
Published: November 2021

Abstract
The onset of plant life is characterized by a major phase transition. During early heterotrophic seedling establishment, seed storage reserves fuel metabolic demands, allowing the plant to switch to autotrophic metabolism. Although metabolic pathways leading to storage compound mobilization are well-described, the regulatory circuits remain largely unresolved. Using an inducible knockdown approach of the evolutionarily conserved energy master regulator Snf1-RELATED-PROTEIN-KINASE1 (SnRK1), phenotypic studies reveal its crucial function in Arabidopsis thaliana seedling establishment. Importantly, glucose feeding largely restores growth defects of the kinase mutant, supporting its major impact in resource mobilization. Detailed metabolite studies reveal sucrose as a primary resource early in seedling establishment, in a SnRK1-independent manner. Later, SnRK1 orchestrates catabolism of triacylglycerols and amino acids. Concurrent transcriptomic studies highlight SnRK1 functions in controlling metabolic hubs fuelling gluconeogenesis, as exemplified by cytosolic PYRUVATE ORTHOPHOSPHATE DIKINASE (cyPPDK). Here, SnRK1 establishes its function via phosphorylation of the transcription factor BASIC LEUCINE ZIPPER63 (bZIP63), which directly targets and activates the cyPPDK promoter. Taken together, our results disclose developmental and catabolic functions of SnRK1 in seed storage mobilization and describe a prototypic gene regulatory mechanism. As seedling establishment is important for plant vigor and crop yield, our findings are of agronomical importance.
Implementing a stand-alone investigative unit to clear non-fatal shooting cases
Authors: Phillips Scott W , Kim Dae-Young , Drake Greg M , Altheimer Irshad 
Published: November 2021

Abstract
This research contributes to the small but growing body of scholarship examining non-fatal shooting cases. This study is particularly important considering the recent increase in the number of shooting incidents in the USA, and the fact that there are often many more non-fatal shooting cases than fatal outcomes. The Buffalo Police Department developed a specific investigative unit focusing exclusively on non-fatal shootings with the expectation that this would allow one group of detectives to focus on all homicides, while the other group focused exclusively on non-fatal shootings. Data from the Buffalo Police Department included both fatal and non-fatal shooting incidents, and an interrupted time series analysis was used to determine if there was an increase in the number of cases cleared by arrest. Results indicated that the implementation of the specific investigative unit did not influence clearances for non-fatal shootings. Furthermore, contrary to expectations, the numbers of clearances for homicides in the post-intervention period were significantly lower than those in the pre-intervention period. Two conclusions are offered. First, the non-fatal shooting unit was not structured in a way that mimicked a homicide unit, thus lacking the resources to clear non-fatal shooting cases. Secondly, separating investigative units created a ‘silo effect’ where the units may not have communicated enough on similar incidents.
Public Debt, Consumption Growth, and the Slope of the Term Structure
Authors: Nguyen Thien T 
Published: November 2021

Abstract
The debt-to-GDP ratio negatively predicts cumulative nominal consumption growth up to a 10-year horizon, resulting from the ratio’s ability to forecast lower inflation and real growth. Moreover, the debt-to-GDP ratio is positively associated with yield spreads. I rationalize these facts in a model in which positive shocks to government debt cause lower inflation and growth, making bonds attractive assets. Furthermore, because longer-term bonds are less exposed to current debt shock than are shorter-term bonds, they are better hedges, resulting in high yield spreads in high-debt states. The model highlights the importance of fiscal risk in understanding the Treasury bond market.
Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
CCR2- and CCR5-mediated macrophage infiltration contributes to glomerular endocapillary hypercellularity in antibody-induced lupus nephritis
Authors: Zoshima Takeshi , Baba Tomohisa , Tanabe Yamato , Ishida Yuko , Nakatani Kimihiko , Nagata Michio , Mukaida Naofumi , Kawano Mitsuhiro 
Published: November 2021

Abstract

Objectives
LN comprises various glomerular lesions, including endocapillary hypercellularity with macrophage infiltration. In this study, we aimed to clarify the involvement of macrophage-tropic chemokine receptors in the pathogenesis of these glomerular lesions.

Methods
MRL/lpr mouse-derived monoclonal IgG3 antibody-producing hybridomas, 2B11.3 and B1, were injected intraperitoneally into BALB/c mice [wild type (WT)] to induce endocapillary hypercellularity and wire-loop lesions, respectively. The expression of chemokine and chemokine receptors was analysed by quantitative real-time PCR and IF. The roles of chemokine receptors in these lesions were evaluated using chemokine receptor-deficient mice or a selective CCR5 antagonist, maraviroc.

Results
2B11.3 caused glomerular endocapillary hypercellularity with a significant number of glomerular CD68-positive macrophages. Further, enhanced expression of CCL2, CCL3, CCR2, CCR5 and CX3CR1 was observed in the renal cortex, compared with B1 injection, which induced wire-loop lesions. In 2B11.3-induced glomerular lesions, CD68 -positive glomerular macrophages expressed CCL2, CCL3, CCR2, CCR5 and CX3CR1, while glomerular endothelial cells expressed CCL2, CCL3, CX3CL1 and CCR2. When 2B11.3 was injected, CCR2–/– and CCR5–/–, but not CX3CR1–/–, mice exhibited reduced endocapillary hypercellularity, attenuated glomerular macrophage infiltration and improved serum blood urea nitrogen levels. Only CCR2–/– mice developed wire-loop lesions. B1 injection caused wire-loop lesions in these chemokine receptor-deficient mice to a similar extent as WT. Maraviroc treatment reduced 2B11.3-induced endocapillary hypercellularity and improved serum blood urea nitrogen levels.

Conclusion
CCR2 and CCR5 regulate glomerular macrophage infiltration and contribute to the development of glomerular endocapillary hypercellularity in LN. CCR5 inhibition can be a specific therapy for endocapillary hypercellularity without inducing wire-loop lesions.
Disparity in peripheral and renal B-cell depletion with rituximab in systemic lupus erythematosus: an opportunity for obinutuzumab?
Authors: Reddy Venkat R , Pepper Ruth J , Shah Kavina , Cambridge Geraldine , Henderson Scott R , Klein Christian , Kell Loren , Taylor Samuel J , Isenberg David A , Cragg Mark S , Leandro Maria J 
Published: November 2021

AbstractObjectivesTo investigate key factors that may contribute to the variability of rituximab-mediated peripheral and renal B cell depletion (BCD) in SLE.MethodsWe analysed: (i) CD19+ B cell counts in patients with SLE before and 1, 2, 3 and 6 months after treatment with rituximab, comparing them with RA patients; (ii) the presence of B cells in renal biopsies after rituximab therapy; (iii) whether the duration of BCD correlated with patient demographics and B cell expression of CD20 and FcγRIIb; and (iv) the effect of B cell activation factor (BAFF) on the efficiency of rituximab and obinutuzumab at inducing BCD in whole blood assays, in vitro.ResultsIn SLE (n = 71), the duration of BCD was shorter compared with RA (n = 27). B cells were detectable in renal biopsy samples (n = 6) after treatment with rituximab in all patients with poor response while peripheral blood B cells remained low or undetectable in the same patients. There were no significant relationships between peripheral BCD and patient age, disease duration, serum C3 levels or the level of expression of B cell surface proteins CD20 and FcγRIIb. Obinutuzumab was more efficient than rituximab at inducing BCD in whole blood assays, regardless of excess BAFF.ConclusionsBCD in SLE is less efficient than in RA. Renal B cell presence following rituximab treatment was associated with poor outcomes. No significant relationships between any measured B cell related, clinical or laboratory parameters and the efficiency of BCD by rituximab was found. Obinutuzumab was superior to rituximab at inducing BCD.
Brain activation during cognitive reappraisal depending on regulation goals and stimulus valence
Authors: Sokołowski Andrzej , Morawetz Carmen , Folkierska-Żukowska Monika , Łukasz Dragan Wojciech 
Published: November 2021

Abstract
Neural bases of cognitive reappraisal may depend on the direction of regulation (up- or downregulation) and stimulus valence (positive or negative). This study aimed to examine this using a cognitive reappraisal task and conjunction analysis on a relatively large sample of 83 individuals. We identified regions in which activations were common for all these types of emotion regulation. We also investigated differences in brain activation between the ‘decrease’ and ‘increase’ emotional response conditions, and between the regulation of negative and positive emotions. The common activation across conditions involved mainly the prefrontal and temporal regions. Decreasing emotions was associated with stronger involvement of the dorsolateral prefrontal cortex, while increasing with activation of the amygdala and hippocampus. Regulation of negative emotions involved stronger activation of the lateral occipital cortex, while regulation of positive emotions involved stronger activation of the anterior cingulate cortex extending to the medial prefrontal cortex. This study adds to previous findings, not only by doing a conjunction analysis on both emotional valences and regulation goals, but also doing this in a bigger sample size. Results suggest that reappraisal is not a uniform process and may have different neural bases depending on regulation goals and stimulus valence.
Diverging Trends in Single-Mother Poverty across Germany, Sweden, and the United Kingdom: Toward a Comprehensive Explanatory Framework
Authors: Zagel Hannah , Hübgen Sabine , Nieuwenhuis Rense 
Published: November 2021

AbstractTo explain single-mother poverty, existing research has either emphasized individualistic, or contextual explanations. Building on the prevalences and penalties framework (Brady et al. 2017), we advance the literature on single-mother poverty in three aspects: First, we extend the framework to incorporate heterogeneity among single mothers across countries and over time. Second, we apply this extended framework to Germany, the United Kingdom and Sweden, whose trends in single-mother poverty (1990–2014) challenge ideal-typical examples of welfare state regimes. Third, using decomposition analyses, we demonstrate variation across countries in the relative importance of prevalences and penalties to explain time trends in single-mother poverty. Our findings support critiques of static welfare regime typologies, which are unable to account for policy change and poverty trends of single mothers. We conclude that we need to understand the combinations of changes in single mothers’ social compositions and social policy contexts, if we want to explain time trends in single-mother poverty.
Binge Ethanol Exposure in Mice Represses Expression of Genes Involved in Osteoblast Function and Induces Expression of Genes Involved in Osteoclast Differentiation Independently of Endogenous Catalase
Authors: Denys Alexandra , Pedersen Kim B , Watt James , Norman Allison R , Osborn Michelle L , Chen Jin-Ran , Maimone Cole , Littleton Shana , Vasiliou Vasilis , Ronis Martin J J 
Published: November 2021

Abstract
Excessive ethanol consumption is a risk factor for osteopenia. Since a previous study showed that transgenic female mice with overexpression of catalase are partially protected from ethanol-mediated trabecular bone loss, we investigated the role of endogenous catalase in skeletal ethanol toxicity comparing catalase knockout to wild-type mice. We hypothesized that catalase depletion would exacerbate ethanol effects. The mice were tested in a newly designed binge ethanol model, in which 12-week-old mice were exposed to 4 consecutive days of gavage with ethanol at 3, 3, 4, and 4.5 g ethanol/kg body weight. Binge ethanol decreased the concentration of serum osteocalcin, a marker of bone formation. The catalase genotype did not affect the osteocalcin levels. RNA sequencing of femoral shaft RNA from males was conducted. Ethanol exposure led to significant downregulation of genes expressed in cells of the osteoblastic lineage with a role in osteoblastic function and collagen synthesis, including the genes encoding major structural bone proteins. Binge ethanol further induced a smaller set of genes with a role in osteoclastic differentiation. Catalase depletion affected genes with expression in erythroblasts and erythrocytes. There was no clear interaction between binge ethanol and the catalase genotype. In an independent experiment, we confirmed that the binge ethanol effects on gene expression were reproducible and occurred throughout the skeleton in males. In conclusion, the binge ethanol exposure, independently of endogenous catalase, reduces expression of genes involved in osteoblastic function and induces expression of genes involved in osteoclast differentiation throughout the skeleton in males.
Auditory Brainstem Response Detection Using Machine Learning: A Comparison With Statistical Detection Methods
Authors: McKearney Richard M. , Bell Steven L. , Chesnaye Michael A. , Simpson David M. 
Published: November 2021

Objectives:
The primary objective of this study was to train and test machine learning algorithms to be able to detect accurately whether EEG data contains an auditory brainstem response (ABR) or not and recommend suitable machine learning methods. In addition, the performance of the best machine learning algorithm was compared with that of prominent statistical detection methods.

Design:
Four machine learning algorithms were trained and evaluated using nested k-fold cross-validation: a random forest, a convolutional long short-term memory network, a stacked ensemble, and a multilayer perceptron. The best method was evaluated on a separate test set and compared with conventional detection methods: Fsp, Fmp, q-sample uniform scores test, and Hotelling’s T2 test. The models were trained and tested on simulated data that were generated based on recorded ABRs collected from 12 normal-hearing participants and no-stimulus EEG data from 15 participants. Simulation allowed the ground truth of the data (“response present” or “response absent”) to be known.

Results:
The sensitivity of the best machine learning algorithm, a stacked ensemble, was significantly greater than that of the conventional detection methods evaluated. The stacked ensemble, evaluated using a bootstrap approach, consistently achieved a high and stable level of specificity across ensemble sizes.

Conclusions:
The stacked ensemble model presented was more effective than conventional statistical ABR detection methods and the alternative machine learning approaches tested. The stacked ensemble detection method may have potential both in automated ABR screening devices as well as in evoked potential software, assisting clinicians in making decisions regarding a patient’s ABR threshold. Further assessment of the model’s generalizability using a large cohort of subject recorded data, including participants of different ages and hearing status, is a recommended next step.
Patient reported outcomes in systemic vasculitis
Authors: Crawshaw Helena , Wells Matthew , Austin Keziah , Janagan Shalini , Robson Joanna C. 
Published: November 2021

Purpose of review
This review paper evaluates the use of patient reported outcome (PROs) in systemic vasculitis and the increasing incorporation of these measures in the evaluation of clinical outcomes and healthcare provision.

Recent findings
Generic PROs such as the SF-12, SF-36, EQ-5D have been used to evaluate health-related quality of life (HRQOL) across the spectrum of vasculitis; including giant cell arteritis, antineutrophil cytoplasmic antibody (ANCA)-related vasculitis and immunoglobulin A vasculitis (IgA) vasculitis. More recently disease-specific PROs have been developed including the associated vasculitis (AAV)-PRO and GCA-PRO, whilst further work is ongoing including a Steroid-PRO.

Summary
Generic and disease-specific PROs are complimentary in nature, but the advent of disease-specific PROs allows evaluation of the impact of specific symptoms and intervention on patient HRQOL. Following the COVID-19 pandemic, the advent of increasing virtual work has brought the potential for electronic-PRO measures to the forefront and is a current area of interest.
Decreased Systemic Busulfan Exposure After Oral Dosing With Concomitant Levetiracetam Compared With Phenytoin
Authors: Artul Tareq , Henig Israel , Nassar Laila , Yehudai-Ofir Dana , Scherb Inna , Lurie Yael , Efrati Edna , Zuckerman Tsila , Kurnik Daniel 
Published: November 2021

Background:
Busulfan (Bu) conditioning used in hematopoietic stem cell transplantation may induce seizures, and prophylactic antiepileptic treatment is recommended. Following updated guidelines, in August 2019, the adult hematopoietic stem cell transplantation department of the Rambam Health Care Campus (Haifa, Israel) switched the antiepileptic prophylaxis protocol from phenytoin to oral levetiracetam during oral Bu conditioning. The aim of this study was to compare the pharmacokinetic parameters of Bu after oral dosing between patients receiving phenytoin and those receiving levetiracetam prophylaxis.

Methods:
This study was a retrospective cohort study in adults undergoing myoablative conditioning with oral Bu between August 2018 and August 2020. Bu pharmacokinetic parameters (AUC0-6, C0, Cmax, and Tmax) were compared in patients treated with phenytoin comedication (during the year before the change in policy) and levetiracetam comedication (during the year after the change). Potential confounders were accounted for including age, azole comedication, and body weight.

Results:
There were no significant differences in demographic and clinical parameters or weight-corrected Bu dose between the phenytoin group (n = 28) and the levetiracetam group (n = 25). There was no difference in the rate of voriconazole comedication, but fluconazole was more common in the phenytoin group (P = 0.026). The median AUC0-6 was significantly lower in the levetiracetam group (949 μM*min; IQR = 806 to 1101 μM*min) than in the phenytoin group (1208 μM*min; IQR = 1087 to 1389 μM*min; P < 0.001). This is a clinically significant difference of 258 μM*min (21%). Azole use was not associated with Bu exposure.

Conclusions:
The findings suggest that, after treatment with oral Bu, oral levetiracetam comedication is associated with reduced systemic exposure compared with phenytoin comedication, possibly because of decreased bioavailability.
A 30-Year Radiation Safety Prospectus Describing Organizational Drivers, Program Activities, and Outcomes
Authors: Gutierrez J. M. , Emery R. J. 
Published: November 2021

Abstract
In 1992, the University of Texas Health Science Center at Houston (UTHealth) Radiation Safety Program began assembling data on a monthly basis that described various program drivers and associated activities. A summary of the data was assembled on an annual basis and shared with the professional health physics community at the 10-y and 20-y intervals. With the inclusion of 1991 data points, three decades (1991 to 2020) of data have now been collected and summarized into an updated program prospectus. The prospectus models a commercial enterprise prospectus provided to potential investors and displays various program indicator parameters. The consistent formatting of the data affords an easily digestible and succinct snapshot of program activities and trends. Various program stakeholder’s feedback regarding this data continues to be well received. Additionally, UTHealth provides increasing support for UT Physicians clinics throughout the greater Houston, Texas area. The prospectus allows succinct description of the drivers of the program, revealed interesting trends, and has identified training needs for both existing personnel and academic programs that support the radiation protection sciences.