bluuebunny/crossref_metadata_2025_split huggingface dataset:
Al-Kindī’s Two-Volume Compendium of Aristotelian Philosophy: Al-Falsafa al-Ūlā and al-Falsafa al-Dākhila
Authors: Stewart Devin J. 
Published: December 2021

Abstract
This study argues that the first two titles listed in the bibliography of Abū Yūsuf Yaʿqūb b. Isḥāq al-Kindī (d. ca. 259/873) presented in the Fihrist of Ibn al-Nadīm (d. 380/990) – his well-known work al-Falsafa al-ūlā (First Philosophy), on metaphysics, and a lost work entitled al-Falsafa al-dākhila (Internal Philosophy) – form an intentional pair. Together, they presented an epitome of Aristotle’s collective works on philosophy, including an outline of metaphysics in al-Falsafa al-ūlā and a discussion of detailed questions of logic, physics, psychology, and metaphysics in al-Falsafa al-dākhila. Drawing primarily on al-Kindī’s work On the Quantity of Aristotle’s Books, the study suggests several emendations to the full title of al-Falsafa al-dākhila as recorded in the Fihrist of Ibn al-Nadīm.
Deep Eye Clouds in Tropical Cyclone Trami (2018) during T-PARCII Dropsonde Observations
Authors: Hirano Soichiro , Ito Kosuke , Yamada Hiroyuki , Tsujino Satoki , Tsuboki Kazuhisa , Wu Chun-Chieh 
Published: December 2021

Abstract
The sporadic formation of short-lived convective clouds in the eye of Tropical Cyclone (TC) Trami (2018) is investigated using dropsonde data and simulation results from a coupled atmosphere–ocean model. According to the satellite data, top height of the convective clouds exceeds 9 km above mean sea level, considerably taller than that of typical hub clouds (2–3 km). These clouds are located 10–30 km away from the TC center. Hence, these convective clouds are called deep eye clouds (DECs) in this study. The dropsonde data reveal an increase in relative humidity in the eye region during the formation of DECs. Short-lived convective clouds are simulated up to the middle troposphere in the eye region in the coupled model. Investigation of thermodynamic conditions shows a weakened low-level warm core and associated favorable conditions for convection in the eye region during the formation of DECs. DECs are formed after the weakening and outward displacement of convective heating within the eyewall. To elucidate the influence of the changes in convective heating within the eyewall on the formation of DECs, we calculate secondary circulation and associated adiabatic warming induced by convective heating within the eyewall using the Sawyer–Eliassen equation. In the eye region, weakening of subsidence and associated vertical potential temperature advection is observed as DECs are formed. This suggests that the weakening and outward displacement of convective heating within the eyewall create favorable conditions for the sporadic formation of DECs.
Frailty Score as a Predictor of Outcomes in Geriatric Patients with Isolated Hip Fractures
Authors: Sang Whiyie A. , Durrani Hamza , Liu Huazhi , Clark Jason M. , Ferber Laurence , Hagan Joshua , Richards Winston , Taylor Dana , Watson Carrie , Ang Darwin 
Published: December 2021

Background Isolated hip fractures (IHFs) are a cause of morbidity and mortality in the geriatric population aged >65 years. Frailty has been identified as a determinant for patient outcomes in other surgical specialties. The purpose of this study is to determine if frailty severity is a predictor of outcomes in IHF in the geriatric population. Methods This is a retrospective study in a state and ACS Level 2 trauma center. Patients with IHF were reviewed between January 2018 and January 2020. Primary outcome was in-patient mortality. Secondary outcomes include perioperative outcome measures such as UTI, HCAP, DVT, readmission, length of stay, ICU length of stay, nutritional status, and discharge destination. Patients were stratified into mild (1-2), moderate (3-5), and severe (5-7) frailty using the Rockwood Frailty Score (RFS). Clinical characteristics and outcomes were analyzed. Results We identified 470 patients with IHF who were stratified by mild (N=316), moderate (N-123), and severe (N=31) frailty. Frailty worsened with increasing age (P < .0001). Those who were less frail were more likely discharged home (P < .04). Severely frail patients were more likely discharged to hospice (P < .01). Severely frail patients also were more likely to develop DVT (P < .04) and have poorer nutritional status (P < .02). There were no differences among groups for in-patient mortality. Conclusion Severely frail patients are more likely to be malnourished at baseline and be discharged to hospice care. The RFS is a reliable objective tool to identify high-risk patients and guide goals of care discussion for operative intervention in isolated traumatic hip fractures.
Effects of seawater corrosion environment on the impact behavior of multi-walled carbon nanotube and SiO2 reinforced basalt/epoxy hybrid nanocomposites
Authors: Demirci İbrahim , Avcı Ahmet 
Published: December 2021

In this study, the impact behaviors of nano silica (SiO2 nanoparticles), MWCNTs (multi-walled carbon nanotube), and SiO2+MWCNTs (nano silica vs multi-walled carbon nanotube hybrid) nanoparticle additives in basalt fiber reinforced composites exposed to seawater corrosion were investigated. The Mediterranean was chosen as the corrosive sea water due to its high salinity. Basalt fiber reinforced composites immersed in seawater have quick mass absorption during the first 30 days. However, it can also vary between the first 28 and 40 days depending on the structure of the composite and environmental conditions. Immersion times were determined as 0, 10, 20, and 40 days. Tensile and low velocity impact tests were performed to evaluate the mechanical performance after seawater corrosion. Low velocity impact tests were carried out at 10 and 20 J energy levels. The aim of this study was to examine the effects of corrosion caused by quick mass absorption on the tensile and impact behaviors of basalt fiber reinforced composites. And also to investigate the contribution of SiO2 and MWCNT nanoparticle additives to the mass absorption mechanism and mechanical performance of basalt fiber reinforced composites. SiO2 and MWCNT nanoparticle additives increased the tensile and impact strength of basalt fiber reinforced composites. However, the tensile and impact behaviors of nanoparticle filled and nanoparticles unfilled basalt fiber reinforced composites were adversely affected by the seawater corrosion environment. Due to the geometric structure of SiO2 nanoparticles, the best mechanical performance was observed in SiO2 filled basalt fiber reinforced composites.
Cultural Competence of Turkish Nurses and Nursing Students: An Integrative Literature Review
Authors: Aydogdu Ana Luiza Ferreira 
Published: December 2021

Introduction: Turkish population is characterized by its great cultural diversity, thus, Turkish nurses and nursing students often interact with patients of different cultural backgrounds from theirs. Cultural competence is needed to provide qualified contemporary nursing care. This study aimed to explore the literature on the cultural competence of Turkish nurses and nursing students. Methodology: The Whittemore and Knafl review methodology was used to extract, summarize, and synthesize data of 15 primary research articles published between January 2011 and January 2021. The search was done in the Turkish Academic Network and Information Center—ULAKBIM (PubMed, TRDizin, DergiPark). Results: Three themes were identified: cultural competence, cultural-related problems, and importance of training on transcultural nursing. Discussion: Appropriate educational courses on transcultural nursing should be implemented in Turkish nursing schools as well as in continuing education programs for Turkish nurses.
Abnormal Bone Morphology in Charcot-Marie-Tooth Disease
Authors: Michalski Max P. , An Tonya W. , Haupt Edward T. , Yeshoua Brandon , Salo Jari , Pfeffer Glenn 
Published: December 2021

Background: Although long suspected, it has yet to be shown whether the foot and ankle deformities of Charcot-Marie-Tooth disease (CMT) are generally associated with abnormalities in osseous shape. Computed tomography (CT) was used to quantify morphologic differences of the calcaneus, talus, and navicular in CMT compared with healthy controls. Methods: Weightbearing CT scans of 21 patients (27 feet) with CMT were compared to those of 20 healthy controls. Calcaneal measurements included radius of curvature, sagittal posterior tuberosity-posterior facet angle, and tuberosity coronal rotation. Talar measurements included axial and sagittal body-neck declination angle, and coronal talar head rotation. Surface-mesh model analysis of the hindfoot was performed comparing the average of the CMT cohort to the controls using a CT analysis software (Disior Bonelogic 2.0). Means were compared with a t test ( P < .05). Results: CMT patients had significantly less talar sagittal declination vs controls (17.8 vs 25.1 degrees; P < .05). Similarly, CMT patients had less talar head coronal rotation vs controls (30.8 vs 42.5 degrees; P < .001). The calcaneal radius of curvature in CMT patients was significantly smaller than controls (822.8 vs 2143.5 mm; P < .05). CMT sagittal posterior tuberosity–posterior facet angle was also significantly different from that of controls (60.3 vs 67.9 degrees respectively; P < .001). Surface-mesh model analysis demonstrated the largest differences in morphology at the navicular tuberosity, medial talar head, sustentaculum tali, and anterior process of the calcaneus. Conclusion: This is the first study to quantify the morphologic differences in hindfoot osteology seen in CMT patients. Patients identified with osseous changes of the calcaneus, especially a smaller axial radius of curvature, may benefit from a 3-dimensional osteotomy for correction.
Analysis of immune-mediated reactions in patients with non-small cell lung cancer treated with nivolumab and its association with effectiveness
Authors: Cortijo-Cascajares Susana , Cercós-Lletí Ana Cristina , Ortiz-Pérez Sara , Caro-Teller José Manuel , Ferrari-Piquero José Miguel 
Published: December 2021

Objective To study immune-related adverse events (irAEs) in non-small cell lung cancer (NSCLC) patients treated with nivolumab, as well as to assess whether these reactions could be predictors of further effectiveness of therapy. Methods Retrospective, observational and longitudinal study. All NSCLC patients who received nivolumab between February 2015-May 2020 were included. In terms of safety, irAEs and their severity were registered and to evaluate the effectiveness, overall survival (OS) and progression free survival (PFS) were calculated. Results 75 patients were included. 32 patients (43%) were reported irAES. Mainly the irAEs affected the skin (36%). Followed by pneumonitis (20%), gastrointestinal reactions (12%), endocrine (12%) and hepatitis (12%). Regarding severity, 92% were moderate. The median PFS was 9.49 months on the group with irAEs versus 1.99 months on the group without irAEs group (p < 0.0001). The median OS was 17.44 months versus 7.67 months respectively (p = 0.0001). According to the incidence of irAEs developed ( = > 2 vs. 1 vs. 0), the median PFS was 20.53 versus 5.35 versus 1.99 months respectively (p < 0.0001). The median OS was 23.41 versus 15.80 versus 7.67 months, respectively (p = 0.0002) Conclusion In a significant number of patients irAEs occur, generally of grade 1–2 severity, affecting mainly the skin, lungs and gastrointestinal system. We confirm that the development of irAEs in patients with NSCLC treated with nivolumab is a strong predictor of treatment effectiveness in both PFS and OS, with statistically significant results. On those patients who experience two or more immunorelated adverse events the greatest benefit has been observed.
Rapid health evaluation in migrant peoples in transit through Darien, Panama: protocol for a multimethod qualitative and quantitative study
Authors: Gabster Amanda , Jhangimal Monica , Erausquin Jennifer Toller , Suárez José Antonio , Pinzón-Espinosa Justo , Baird Madeline , Katz Jennifer , Beltran-Henríquez Davis , Cabezas-Talavero Gonzalo , Henao-Martínez Andrés F. , Franco-Paredes Carlos , Agudelo-Higuita Nelson I. , Pachar Mónica , González José Anel , Rodriguez Fátima , Pascale Juan Miguel ,   Migrant Peoples in Transit Study Group
Published: December 2021

Background: The world is currently unprepared to deal with the drastic increase in global migration. There is an urgent need to develop programs to protect the well-being and health of migrant peoples. Increased population movement is already evident throughout the Americas as exemplified by the rising number of migrant peoples who pass through the Darien neotropical moist broadleaf forest along the border region between Panama and Colombia. The transit of migrant peoples through this area has an increase in the last years. In 2021, an average of 9400 people entered the region per month compared with 2000–3500 people monthly in 2019. Along this trail, there is no access to health care, food provision, potable water, or housing. To date, much of what is known about health needs and barriers to health care within this population is based on journalistic reports and anecdotes. There is a need for a comprehensive approach to assess the health care needs of migrant peoples in transit. This study aims to describe demographic characteristics, mental and physical health status and needs, and experiences of host communities, and to identify opportunities to improve health care provision to migrant peoples in transit in Panama. Study design and methods: This multimethod study will include qualitative ( n = 70) and quantitative ( n = 520) components. The qualitative component includes interviews with migrant peoples in transit, national and international nongovernmental organizations and agencies based in Panama. The quantitative component is a rapid epidemiological study which includes a questionnaire and four clinical screenings: mental health, sexual and reproductive health, general and tropical medicine, and nutrition. Conclusion: This study will contribute to a better understanding of the health status and needs of migrant peoples in transit through the region. Findings will be used to allocate resources and provide targeted health care interventions for migrant peoples in transit through Darien, Panama.
Public patient views of artificial intelligence in healthcare: A nominal group technique study
Authors: Musbahi Omar , Syed Labib , Le Feuvre Peter , Cobb Justin , Jones Gareth 
Published: December 2021

Objectives The beliefs of laypeople and medical professionals often diverge with regards to disease, and technology has had a positive impact on how research is conducted. Surprisingly, given the expanding worldwide funding and research into Artificial Intelligence (AI) applications in healthcare, there is a paucity of research exploring the public patient perspective on this technology. Our study sets out to address this knowledge gap, by applying the Nominal Group Technique (NGT) to explore patient public views on AI. Methods A Nominal Group Technique (NGT) was used involving four study groups with seven participants in each group. This started with a silent generation of ideas regarding the benefits and concerns of AI in Healthcare. Then a group discussion and round-robin process were conducted until no new ideas were generated. Participants ranked their top five benefits and top five concerns regarding the use of AI in healthcare. A final group consensus was reached. Results Twenty-Eight participants were recruited with the mean age of 47 years. The top five benefits were: Faster health services, Greater accuracy in management, AI systems available 24/7, reducing workforce burden, and equality in healthcare decision making. The top five concerns were: Data cybersecurity, bias and quality of AI data, less human interaction, algorithm errors and responsibility, and limitation in technology. Conclusion This is the first formal qualitative study exploring patient public views on the use of AI in healthcare, and highlights that there is a clear understanding of the potential benefits delivered by this technology. Greater patient public group involvement, and a strong regulatory framework is recommended.
Does the Scale or Speed of Immigration Generate Nativism? Evidence from a Comparison of New Zealand Regions
Authors: Wilson Chris , Shastri Sanjal , Frear Henry 
Published: December 2021

Nativism, the belief that the rights of those who came first should be prioritized over immigrants, is an increasingly important driver of the rise of far-right populism. It is also leading to hate crimes and even terrorist attacks against immigrants. However, it remains unclear when and why local communities come to oppose immigration. One important set of questions concerns whether nativism is most likely to emerge in societies in which immigrants constitute a higher proportion of the total population or those where there is rapid growth in the immigrant population, even if absolute numbers or their proportion of society remain low. This paper employs multivariate analysis to test these two hypotheses. We use data from a survey of nativist (and populist) sentiment in New Zealand conducted in 2020 along with population data from the national censuses of 2013 and 2018. We compare the results from all New Zealand regions. Our findings strongly support the second hypothesis regarding the importance of the rate of growth in the immigrant population. Those regions that have the highest rate of change in immigrant populations present the highest levels of nativist sentiment, despite their immigrant populations being both small in size and as a proportion of the local population. Conversely, those regions where immigrant numbers are high or they constitute a large proportion of the local population return low levels of nativist sentiment.
The impact of therapeutics on mortality in hospitalised patients with COVID-19: systematic review and meta-analyses informing the European Respiratory Society living guideline
Authors: Crichton Megan L. , Goeminne Pieter C. , Tuand Krizia , Vandendriessche Thomas , Tonia Thomy , Roche Nicolas , Chalmers James D. 
Published: December 2021

Hospitalised patients with coronavirus disease 2019 (COVID-19) have a high mortality rate. There are an increasing number of published randomised controlled trials for anti-inflammatory, anti-viral and other treatments. The European Respiratory Society Living Guidelines for the Management of Hospitalised Adults with COVID-19 were published recently, providing recommendations on appropriate pharmacotherapy.Patient, Intervention, Comparator and Outcomes questions for key interventions were identified by an international panel and systematic reviews were conducted to identify randomised controlled trials meeting the inclusion criteria. The importance of end-points were rated, and mortality was identified as the key “critical” outcome for all interventions. Random-effects meta-analysis was used to pool studies and provide effect estimates for the impact of treatments on mortality.Corticosteroids, hydroxychloroquine, azithromycin, remdesivir, anti-interleukin (IL)-6 monoclonal antibodies, colchicine, lopinavir/ritonavir and interferon-β have been reviewed.Our results found further evidence in support of the use of corticosteroids, particularly dexamethasone, and anti-IL-6 receptor monoclonal antibody therapy. These data support the need to identify additional therapies with beneficial effects on mortality.
Seminal fluid proteins induce transcriptome changes in the Aedes aegypti female lower reproductive tract
Authors: Amaro I. Alexandra , Ahmed-Braimah Yasir H. , League Garrett P. , Pitcher Sylvie A. , Avila Frank W. , Cruz Priscilla C. , Harrington Laura C. , Wolfner Mariana F. 
Published: December 2021

Abstract
Background
Mating induces behavioral and physiological changes in the arbovirus vector Aedes aegypti, including stimulation of egg development and oviposition, increased survival, and reluctance to re-mate with subsequent males. Transferred seminal fluid proteins and peptides derived from the male accessory glands induce these changes, though the mechanism by which they do this is not known.

Results
To determine transcriptome changes induced by seminal proteins, we injected extract from male accessory glands and seminal vesicles (MAG extract) into females and examined female lower reproductive tract (LRT) transcriptomes 24 h later, relative to non-injected controls. MAG extract induced 87 transcript-level changes, 31 of which were also seen in a previous study of the LRT 24 h after a natural mating, including 15 genes with transcript-level changes similarly observed in the spermathecae of mated females. The differentially-regulated genes are involved in diverse molecular processes, including immunity, proteolysis, neuronal function, transcription control, or contain predicted small-molecule binding and transport domains.

Conclusions
Our results reveal that seminal fluid proteins, specifically, can induce gene expression responses after mating and identify gene targets to further investigate for roles in post-mating responses and potential use in vector control.
Injectisome T3SS subunits as potential chaperones in the extracellular export of Pectobacterium carotovorum subsp. carotovorum bacteriocins Carocin S1 and Carocin S3 secreted via flagellar T3SS
Authors: Wu Huang-Pin , Derilo Reymund C. , Chen Han-Ling , Li Tzu-Rung , Lagitnay Ruchi Briam James S. , Chan Yung-Chieh , Chuang Yutin , Chuang Duen-Yau 
Published: December 2021

AbstractPectobacterium carotovorum subsp. carotovorum (Pcc) causes soft-rot disease in a wide variety of plants resulting in economic losses worldwide. It produces various types of bacteriocin to compete against related plant pathogens. Studies on how bacteriocins are extracellularly secreted are conducted to understand the mechanism of interbacterial competition. In this study, the secretion of the low-molecular-weight bacteriocins (LMWB) Carocin S1 and Carocin S3 produced by a multiple-bacteriocin producing strain of Pcc, 89-H-4, was investigated. Tn5 insertional mutagenesis was used to generate a mutant, TH22–6, incapable of LMWBs secretion. Sequence and homology analyses of the gene disrupted by transposon Tn5 insertion revealed that the gene sctT, an essential component of the injectisome type III secretion machinery (T3aSS), is required for the secretion of the bacteriocins. This result raised a question regarding the nature of the secretion mechanism of Pcc bacteriocins which was previously discovered to be secreted via T3bSS, a system that utilizes the bacterial flagellum for extracellular secretions. Our previous report has shown that bacteriocin Carocin S1 cannot be secreted by mutants that are defective of T3bSS-related genes such as flhA, flhC, flhD and fliC. We knocked out several genes making up the significant structural components of both T3aSS and T3bSS. The findings led us to hypothesize the potential roles of the T3aSS-related proteins, SctT, SctU and SctV, as flagellar T3SS chaperones in the secretion of Pcc bacteriocins. This current discovery and the findings of our previous study helped us to conceptualize a unique Type III secretion system for bacteriocin extracellular export which is a hybrid of the injectisome and flagellar secretion systems.