bluuebunny/crossref_metadata_2025_split huggingface dataset:
SMART SURVEILLANCE DAN KETERATURAN SOSIAL (STUDI KASUS IMPLEMENTASI SMART CITY DI KOTA BANDUNG)
Authors: Alkaf Annadi Muhammad , Sutrisno Budi 
Published: May 2021

Studi tentang pengawasan (surveillance) telah berkembang dari konsep panopticon yang rigid ke konsep yang lebih halus dan cair. Konsep dan implementasi surveillance ini berkaitan erat dengan upaya menciptakan keteraturan sosial. Penelitian ini membahas konsep smart surveillance yang merupakan suatu jenis pengawasan dengan memanfaatkan sistem teknologi dalam kaitannya dengan upaya menciptakan keteraturan sosial di masyarakat, khususnya masyarakat di perkotaan. Penelitian ini dibangun berdasarkan pendekatan kualitatif dengan jenis studi kasus untuk memperdalam masalah dan menangkap maknamakna di lapangan secara holistik dan komprehensif. Pengumpulan data dilakukan melalui serangkaian observasi dan wawancara mendalam serta ditunjang dengan studi literatur. Lokasi penelitian bertempat di Kota Bandung yang merupakan salah satu pionir implementasi smart city di Indonesia. Hasil penelitian menunjukkan penggunaan teknologi surveillance di Kota Bandung terbukti efektif dan efisien dalam menciptakan keteraturan sosial. Hasil penelitian menunjukkan penggunaan teknologi surveillance dalam bentuk CCTV telah berhasil menciptakan keteraturan dengan memanfaatkan CCTV untuk mengawasi, memahami pola aktivitas para pelanggar untuk kemudian dilakukan penindakan. Dengan demikian teknologi telah menjadi perangkat kontrol dalam rangka menciptakan keteraturan sosial di perkotaan.Â Â The study of surveillance has been evolved from the rigid panopticon concept to the more fluid one. The concept and implementation of surveillance are contributed to establish social order. This research mainly discusses about smart surveillance concept, one kind of surveillance that uses technological system in order to establish social order in society, particularly on urban society. This research is conducted on a qualitative approach by case study to get the deeper understanding of problems and to get the comprehensive and holistic means that showed in surveillance implementation. The data was collected by observation and indepth interview, which also supported by literature study. The location of this study is located in Bandung City, which is one of the pioneers of the implementation of smart city in Indonesia. The results of the study showed that implementation of surveillance technology in Bandung City has proved to be effective and efficient in order to establish social order in society. This study has also shown that thereâ€™s a transformation of social control instrument, where the role of traditional belief and social norm to maintain social order has been replaced by technological system.
Digital Pathology Initiatives and Experience of a Large Academic Institution During the Coronavirus Disease 2019 (COVID-19) Pandemic
Authors: Lujan Giovanni M. , Savage Johanna , Shana'ah Arwa , Yearsley Martha , Thomas Diana , Allenby Patricia , Otero Jose , Limbach Abberly Lott , Cui Xiaoyan , Scarl Rachel T. , Hardy Tanner , Sheldon Jesse , Plaza Jose A. , Whitaker Bonnie , Frankel Wendy , Parwani Anil V. , Li Zaibo 
Published: May 2021

Context.—
Pathology practices have begun integrating digital pathology tools into their routine workflow. During 2020, the coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged as a pandemic, causing a global health crisis that significantly affected the world population in several areas, including medical practice, and pathology was no exception.

Objective.—
To summarize our experience in implementing digital pathology for remote primary diagnosis, education, and research during this pandemic.

Design.—
We surveyed our pathologists (all subspecialized) and trainees to gather information about their use of digital pathology tools before and during the pandemic. Quality assurance and slide distribution data were also examined.

Results.—
During the pandemic, the widespread use of digital tools in our institution allowed a smooth transition of most clinical and academic activities into remote with no major disruptions. The number of pathologists using whole slide imaging (WSI) for primary diagnosis increased from 20 (62.5%) to 29 (90.6%) of a total of 32 pathologists, excluding renal pathology and hematopathology, during the pandemic. Furthermore, the number of pathologists exclusively using whole slide imaging for primary diagnosis also increased from 2 (6.3%) to 5 (15.6%) during the pandemic. In 35 (100%) survey responses from attending pathologists, 21 (60%) reported using whole slide imaging for remote primary diagnosis following the Centers for Medicare and Medicaid Services waiver. Of these 21 pathologists, 18 (86%) responded that if allowed, they will continue using whole slide imaging for remote primary diagnosis after the pandemic.

Conclusions.—
The pandemic served as a catalyst to pathologists adopting a digital workflow into their daily practice and realizing the logistic and technical advantages of such tools.
Some Reactive Lesions of Bone Are Probably Neoplasms
Authors: Memon Raima A. , Wei Shi , Siegal Gene P. 
Published: May 2021

Context.—A number of fibro-osseous and osteocartilaginous lesions, especially common in the small bones of the hand and feet, pose a diagnostic challenge and have historically been thought to be reactive lesions. However, modern molecular techniques when supplementing clinical, radiographic, and histologic evaluation suggest they may, in fact, be neoplasms.Objective.—To review the clinical presentation and histopathologic, molecular, and radiologic features of selective bone lesions, focusing most specifically on subungual exostosis, florid reactive periostitis, and bizarre periosteal osteochondromatous proliferation.Data Sources.—Literature review and personal experience are the sources of this review.Conclusions.—Some lesions previously thought to be reactive are locally aggressive and demonstrate reproducible molecular abnormalities, and thus may be neoplasms. Although most common in the bones of the fingers and toes, these lesions also occur in long and other bones. The clinical presentations, radiologic appearances, and histopathologic features often overlap, making the diagnosis challenging, and these lesions may require molecular evaluation to maximize accurate prognostication.
Escribir en sueños. Zambrano, Derrida y la temporalidad de la novela
Authors: Valls Boix Juan Evaristo 
Published: May 2021

El propósito del presente estudio consiste en pensar la ambivalencia con que Zambrano aborda el género de la novela. De un lado, las reflexiones en La confesión, género literario posicionan a Zambrano próxima a las críticas de Benjamin y Adorno a propósito de la cosificación de la novela como género burgués de consumo. De otro lado, sus exposiciones en El sueño creador conciben la novela como la actualización del sueño de la libertad mediante el que el hombre pensarse desbordando la medida de lo humano. Esta ambivalencia del género revela el relato como la condición de posibilidad e imposibilidad de una temporalidad incalculable, no cuantitativa, lo que vinculará las reflexiones de Zambrano con el pensamiento de Derrida.
The aim of this study is to think the ambivalence with which Zambrano tackles the novel’s gender. On the one side, her thesis in La confesión, género literario bring Zambrano closer to Benjamin, and Adorno’s critique to the novel as a bourgeois and consumable gender. On the other side, Zambrano’s statements in El sueño creador depict the novel as the fulfillment of a dream of freedom, where man can question himself beyond the limits of the human. In this ambivalence, the narrative gender shows both the conditions of possibility and the conditions of impossibility of a non-quantitative temporality. This aporetic character of the novel opens a discussion between Zambrano and Derrida’s thought.
Water Quality of Pond Irrigation ChannelsBased on the Community Structure of Macrozoobenthosin Legonkulon,Subang, West Java
Authors: Adelianti Atiek , Hamdani Herman , Pratama RuskyIntan , Herawati Heti 
Published: May 2021

This research aimed to analyze the quality of water in pond irrigation channels by examining the community structure of macrozoobenthos in Legonkulon, Subang Regency, West Java. The research was conducted in the Pond Irrigation Channels, Subang Regency, West Java starting from July until September 2020. This research method used a survey method using primary data in the form of physical chemistry of aquatic data, macrozoobenthos density, diversity index, uniformity index. The method used in data collecting techniques was purposive sampling in determining 4 stations and 3 repetitions. Data analysis in this research used descriptive analysis. Research results found 28 species consisting of 3 phyla, namely Mollusca, Arthropoda, and Annelida. The species that dominate the four stations are Filopaludinajavanica and Tarebiagranifera. Makrozoobenthos density ranges from 40 – 295 ind/m2. Makrozoobenthos diversity index in the medium category 1.0 < H’ <3.322. Uniformity values ranged from 0,43 to 0,81 with low to high category. The highest uniformity index was found at station 3, and the lowest uniformity index was at station 4, while at station 1 and station 2 had a moderate uniformity index. The results of the macrozoobenthos community structure showed that the water quality of the pond irrigation channels in Legonkulon was classified as being medium polluted.
Experience and Perceptions of Medical and Dental Interns on the Effects of the COVID- 19 Pandemic on their Internship Program- A Questionnaire Based Study in Makkah Region of Saudi Arabia
Authors: Shetty Karunakar , Wali Othman , M. Maleh Abdulaziz Talal , Alharthi Zaid Naif , Zahran Mahmoud Hani , Khairudein Maged Mhmdnzar 
Published: May 2021

Introduction: COVID-19 is a highly infectious disease caused by an RNA virus belonging to a large family of coronaviruses. WHO declared COVID-19 as a public health emergency and classified it as a pandemic. The COVID-19 pandemic affected the medical education globally.
Aim of the Study: The aim of the study is to evaluate the impact of COVID-19 on the internship program.
Materials and Methods: A cross‑sectional study was conducted among the medical and dental students of various universities in Makkah region of Saudi Arabia. A questionnaire consisting of 15 close ended, pre-tested questions was developed to determine the experiences and perceptions of medical and dental interns due to COVID-19. The data were tabulated and analyzed using SPSS version 21. Chi-square test was used to assess the experiences and perceptions among the Medical and Dental interns. P-value of less than 0.05 was considered statistically significant. Results: The study included 453 participants, out of which 253 were dental interns and 200 were medical interns. 231 (51%) of male interns participated in this study and 222 (49%) female interns participated. 140 (55.6%) and 138 (69.3%) of the participants of the dental and medical interns respectively felt COVID-19 affected options to select specialties of their interest for post-graduation, whereas, 112 (44.4%) and 61 (30.7%) of the dental and medical interns felt other way. Conclusion: Majority of the participants reported that COVID-19 did not affect them psychologically. In addition, most of the medical and dental interns felt covid -19 affected opinions to select specialties of their interest for post-graduation.
Health self-perception of primary care users / Autopercepção de saúde de usuárias da atenção primária
Authors: Lima Eliane de Fatima Almeida , Costa Leite Franciele Marabotti , Storari Silva Juliane Almeida , Luis Mayara Alves , Batista Karla de Melo 
Published: May 2021

Objetivo: Determinar a autopercepção de saúde de usuárias da atenção primária e verificar a associação com fatores socioeconômicos, clínicos e experiência de violência. Métodos: Estudo epidemiológico, analítico, do tipo transversal realizado com 991 mulheres em 26 Unidades Básica de Vitória, Espirito Santo. Variáveis socioeconômicas, clínicas, de percepção de saúde, e, as experiências de violência praticada pelo parceiro íntimo ao longo da vida foram utilizadas nas análises dos dados. Teste de Regressão de Poisson para análise multivariada foi utilizada para obtenção das razões de prevalência, sendo o ajuste das variáveis realizado pelo método tipo backward, tendo por base o modelo hierárquico. Resultados: Mulheres com 40 anos ou mais, não brancas, com escolaridade de até quatro anos, evangélicas e sem trabalho remunerado percebem mais frequentemente a saúde negativamente. Conclusões: Características socioeconômicas, clínicas e de experiência de violência por parceiro íntimo podem contribuir para percepção negativa da saúde.
The ZEB2‐dependent EMT transcriptional programme drives therapy resistance by activating nucleotide excision repair genes ERCC1 and ERCC4 in colorectal cancer
Authors: Sreekumar Rahul , Al‐Saihati Hajir , Emaduddin Muhammad , Moutasim Karwan , Mellone Massimiliano , Patel Ashish , Kilic Seval , Cetin Metin , Erdemir Sule , Navio Marta Salgado , Lopez Maria Antonette , Curtis Nathan , Yagci Tamer , Primrose John N. , Price Brendan D. , Berx Geert , Thomas Gareth J. , Tulchinsky Eugene , Mirnezami Alex , Sayan A. Emre 
Published: May 2021

Resistance to adjuvant chemotherapy is a major clinical problem in the treatment of colorectal cancer (CRC). The aim of this study was to elucidate the role of an epithelial to mesenchymal transition (EMT)‐inducing protein, ZEB2, in chemoresistance of CRC, and to uncover the underlying mechanism. We performed IHC for ZEB2 and association analyses with clinical outcomes on primary CRC and matched CRC liver metastases in compliance with observational biomarker study guidelines. ZEB2 expression in primary tumours was an independent prognostic marker of reduced overall survival and disease‐free survival in patients who received adjuvant FOLFOX chemotherapy. ZEB2 expression was retained in 96% of liver metastases. The ZEB2‐dependent EMT transcriptional programme activated nucleotide excision repair (NER) pathway largely via upregulation of the ERCC1 gene and other components in NER pathway, leading to enhanced viability of CRC cells upon oxaliplatin treatment. ERCC1‐overexpressing CRC cells did not respond to oxaliplatin in vivo, as assessed using a murine orthotopic model in a randomised and blinded preclinical study. Our findings show that ZEB2 is a biomarker of tumour response to chemotherapy and risk of recurrence in CRC patients. We propose that the ZEB2‐ERCC1 axis is a key determinant of chemoresistance in CRC.
Transfer of stabilising mutations between different secondary active transporter families
Authors: Cecchetti Cristina , Scull Nicola J. , Mohan Thotegowdanapalya C. , Alguel Yilmaz , Jones Alexandra M. C. , Cameron Alexander D. , Byrne Bernadette 
Published: May 2021

Integral membrane transporters play essential roles in the movement of substrates across biological membranes. One approach to produce transporters suitable for structural studies is to introduce mutations that reduce conformational flexibility and increase stability. However, it can be difficult to predict which mutations will result in a more stable protein. Previously, we stabilised the uric acid‐xanthine transporter, UapA, a member of the SLC23 family, through introduction of a single‐point mutation, G411V, trapping the protein in the inward‐facing conformation. Here, we attempted to stabilise the structurally related BOR1 transporter from Arabidopsis thaliana, a member of the SLC4 family, by introducing the equivalent substitution. We identified possible residues, P362 and M363, in AtBOR1, likely to be equivalent to the G411 of UapA, and generated four mutants, P362V or L and M363F or Y. Stability analysis using heated Fluorescent Size Exclusion Chromatography indicated that the M363F/Y mutants were more stable than the WT AtBOR1 and P362V/L mutants. Furthermore, functional complementation analysis revealed that the M363F/Y mutants exhibited reduced transport activity compared to the P362V/L and WT proteins. Purification and crystallisation of the M363F/Y proteins yielded crystals that diffracted better than WT (5.5 vs 7 Å). We hypothesise that the increased bulk of the F and Y substitutions limits the ability of the protein to undergo the conformational rearrangements associated with transport. These proteins represent a basis for future studies on AtBOR1.
Complete chloroplast genomes of Achnatherum inebrians and comparative analyses with related species from Poaceae
Authors: Wei Xuekai , Li Xiuzhang , Chen Taixiang , Chen Zhenjiang , Jin Yuanyuan , Malik Kamran , Li Chunjie 
Published: May 2021

This article reports the complete chloroplast genome of Achnatherum inebrians, a poisonous herb that is widely distributed in the rangelands of Northern China. The genome is 137 714 bp in total and consists of a large single‐copy (81 758 bp) region and small single‐copy (12 682 bp) region separated by a pair of inverted repeats (21 637 bp). The genome contains 130 genes, including 84 protein‐coding genes, 38 tRNA genes and 8 ribosomal RNA genes, and the guanine + cytosine content is 36.17%. We subsequently performed comparative analysis of complete genomes from A. inebrians and other Poaceae‐related species from GenBank. Thirty‐eight simple sequence repeats were identified, further demonstrating rapid evolution in Poaceae. Finally, the phylogenetic trees of 37 species of Poaceae and 2 species of Amaranthaceae were constructed by using maximum likelihood and Bayesian inference methods, based on the genes of the complete chloroplast genome. We identified hotspots that can be used as molecular markers and barcodes for phylogenetic analysis, as well as for species identification. Phylogenetic analysis indicated that A. inebrians is a member of the genus Stipa rather than Achnatherum.
Exploring triheptanoin as treatment for short chain enoyl CoA hydratase deficiency
Authors: Engelstad Kristin , Salazar Rachel , Koenigsberger Dorcas , Stackowtiz Erin , Brodlie Susan , Brandabur Melanie , De Vivo Darryl C. 
Published: May 2021

AbstractWe explored the benefits of triheptanoin as a treatment for Short Chain Enoyl Co‐A Hydratase (SCEH) deficiency. One child with early onset, severe SCEH Deficiency was treated with triheptanoin, an odd chain oil with anapleurotic properties, for 37 months. Blood and urine chemistry safety measures, motor skills assessment, physical exam, and neurological assessment were monitored over a 27 month period. Modest sustained gains in motor skills, attention, muscle bulk, and strength were observed without any significant adverse effects. Triheptanoin appears to be a promising effective treatment for SCEH Deficiency.
Access to Care and Diagnostic Delays in Juvenile Dermatomyositis: Results From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry
Authors: Neely Jessica , Shalen Julia , Sturrock Hugh , Kim Susan ,   for the Childhood Arthritis and Rheumatology Research Alliance Investigators
Published: May 2021

ObjectiveTo determine factors associated with diagnostic delays and outcomes in juvenile dermatomyositis (JDM) in the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry (CLR).MethodsThis was a cross‐sectional study of subjects aged 0 to 17 years with JDM enrolled to the CLR from 2010 to 2015. Access to care was measured by calculating the distance from the subject zip code of residence to the treating pediatric rheumatology center and determining the state density of pediatric rheumatologists based on the 2015 American College of Rheumatology Workforce Study. Delay was categorized as early (<30 days), typical (1‐3 months), moderate (3‐12 months), and severe (>12 months). Ordered generalized additive models were used to determine the association between these measures and diagnostic delays.ResultsThe median time to diagnosis was 3.1 months; 37.2% of patients experienced moderate delays, and 14.6% experienced severe delays. In a univariate analysis, younger age of disease onset and male sex were associated with delays. Using a generalized additive model accounting for age, sex, race, and ethnicity, increasing distance from treating pediatric rheumatologist and younger age at disease onset were associated with diagnostic delay. There was no association between the state density of rheumatologists and diagnostic delays in this model.ConclusionIn the CLR, we found moderate to severe diagnostic delays in the majority of subjects with JDM. Our data suggest that access to care, measured as the distance traveled to treating rheumatologist, is an important factor associated with delays in care but also highlight age as a contributing factor, suggesting that JDM may be less recognizable in young children.
Human Adult Fibroblast‐like Synoviocytes and Articular Chondrocytes Exhibit Prominent Overlap in Their Transcriptomic Signatures
Authors: Jones Kyle , Angelozzi Marco , Gangishetti Umesh , Haseeb Abdul , de Charleroy Charles , Lefebvre Véronique , Bhattaram Pallavi 
Published: May 2021

ObjectivesFibroblast‐like synoviocytes (FLS) and articular chondrocytes (AC) derive from a common pool of embryonic precursor cells. They are currently believed to engage in largely distinct differentiation programs to build synovium and articular cartilage and maintain healthy tissues throughout life. We tested this hypothesis by deeply characterizing and comparing their transcriptomic attributes.MethodsWe profiled the transcriptomes of freshly isolated AC, synovium, primary FLS, and dermal fibroblasts from healthy adult humans using bulk RNA sequencing assays and downloaded published single‐cell RNA sequencing data from freshly isolated human FLS. We integrated all data to define cell‐specific signatures and validated findings with quantitative reverse transcription PCR of human samples and RNA hybridization of mouse joint sections.ResultsWe identified 212 AC and 168 FLS markers on the basis of exclusive or enriched expression in either cell and 294 AC/FLS markers on the basis of similar expression in both cells. AC markers included joint‐specific and pan‐cartilaginous genes. FLS and AC/FLS markers featured 37 and 55 joint‐specific genes, respectively, and 131 and 239 pan‐fibroblastic genes, respectively. These signatures included many previously unrecognized markers with potentially important joint‐specific roles. AC/FLS markers overlapped in their expression patterns among all FLS and AC subpopulations, suggesting that they fulfill joint‐specific properties in all, rather than in discrete, AC and FLS subpopulations.ConclusionThis study broadens knowledge and identifies a prominent overlap of the human adult AC and FLS transcriptomic signatures. It also provides data resources to help further decipher mechanisms underlying joint homeostasis and degeneration and to improve the quality control of tissues engineered for regenerative treatments.