bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amenaza y vulnerabilidad por basurales a cielo abierto. Aproximación al estado de situación en la provincia de Buenos Aires, Argentina
Authors: Martínez Saucedo María de los Ángeles , Lacava Judith Elizabeth , Bernabeu Pamela Romina 
Published: December 2024

Los basurales a cielo abierto constituyen un problema ambiental debido a la falta de control en la disposición de residuos sólidos urbanos. Estos sitios contaminan suelo, agua y aire, y exponen a las poblaciones que habitan en su cercanía a amenazas a la salud. Tomando como punto de partida la teoría social del riesgo, este artículo busca analizar la vulnerabilidad y amenaza por basurales a cielo abierto en la provincia de Buenos Aires, y hacer una primera aproximación al riesgo. El análisis realizado permitió describir las condiciones de vulnerabilidad y amenaza ofreciendo una primera aproximación al análisis del riesgo por municipio.
Los resultados muestran que gran parte de la población de la provincia de Buenos Aires se encuentra en condiciones de vulnerabilidad media a alta, especialmente en áreas con mayor concentración de basurales a cielo abierto. La integración de indicadores georreferenciados en un modelo de análisis permitió realizar un diagnóstico preliminar, destacando la necesidad de políticas públicas que aborden tanto la gestión de residuos como la reducción de la vulnerabilidad social.
Abstract
Open-air landfills (Basurales a Cielo Abierto -BCA-) in Buenos Aires Province represent a significant environmental issue due to inadequate control over solid urban waste disposal. These sites expose local populations to health hazards by contaminating soil, water, and air. Drawing on social risk theory, this article aims to analyze the vulnerability and threats posed by open-air landfills in the province, providing a preliminary risk assessment. The analysis reveals that a large portion of the population lives in moderate to high vulnerability, particularly in areas with the highest concentration of open-air landfills. Using geo-referenced indicators within an analytical model, the study offers a diagnostic that underscores the need for public policies addressing both waste management and social vulnerability reduction
Impact of Resilience Strategies and Developmental Policies on the Business Performance of Msmes in Krishnagiri District
Authors: Jayakumar H. , Chandran M. 
Published: December 2024

Objectives: The study aims to identify and validate the components of resilience strategies employed by MSMEs in Krishnagiri district. Additionally, it seeks to measure the impact of these strategies and developmental policies on the business performance of MSMEs.

Methods: Primary data were collected from MSME owners and employees across 10 zones in Krishnagiri district. A total of 250 usable responses were gathered using a convenience sampling method, with 25 responses collected per zone. The data were analyzed using structural equation modeling to evaluate the significance and effectiveness of resilience strategies.

Results: The analysis revealed that resilience strategies are crucial for the recovery and sustained growth of MSMEs in the district. These strategies not only support business continuity but also contribute to the overall growth and development of MSMEs, ensuring long-term prudential benefits.

Conclusion: The study concludes that resilience strategies play an essential role in enabling MSMEs to navigate challenges posed by pandemics and natural disasters. By implementing robust resilience strategies, MSMEs can achieve successful business recovery and contribute significantly to economic development at both state and national levels.
Potential risks of occupational exposure to innovative biopharmaceuticals: a review
Authors: Klimov V. I. , Lalymenko O. S. , Korsun L. V. 
Published: December 2024

Introduction. Gene-targeted therapies (gene-targeted, high-tech, and biopharmaceuticals) are developed based on active pharmaceutical ingredients, which are reactive compounds with pleiotropic activity. Such ingredients are associated with health hazards to workers employed at various stages of their production. Clinically significant pharmacological or toxicological effects of innovative medications on employees exposed to these components are unsafe from the perspective of a risk-based approach in occupational medicine.Objective. Assessment of potential risks of occupational exposure to innovative biopharmaceuticals in production or laboratory conditions and approaches to their hygienic management.Materials and methods. The relevant scientific publications were searched and retrieved via electronic bibliographic databases both in the Russian language (eLibrary, CyberLeninka) and in the English language (WoS, Scopus, PubMed). Regulatory documents were analyzed using the Consultant Plus legal information system.Discussion. Specific features of production of new-generation biopharmaceuticals (gene-targeted, high-tech, or biotechnological medications) and the associated risks of occupational exposure to workers in pharmaceutical or laboratory production are considered. It was established that employees of such enterprises are exposed to the combined influence of adverse — biological, physical, and chemical — production environment factors. There is a lack of information on the development of analytical methods for identifying gene-targeted components (high-tech or biotechnological medications) in the workplace air and wastewater, as well as on workplace surfaces. The identified problems of occupational health are related to the lack of legislative instruments and knowledgebased management decisions on the identification of risk factors and control ranges of potential work-related effects of innovative biopharmaceuticals. Such approaches should be based on the principles of hygienic regulation aimed at eliminating or reducing negative industrial effects and ensuring the safety and preservation of employee health.Conclusions. Major methodological approaches to assessing the work-related impact of gene-targeted, high-tech, or biotechnological therapies on employees of pharmaceutical enterprises are determined. These approaches include: (1) toxicological assessment of compounds with the establishment of possible parameters of toxicometry; (2) evaluation of the pharmacological and toxicokinetic features of gene-targeted therapeutical components; (3) development of methods for their quantitative determination in various environments; (4) establishment of biomarkers of exposure and related effects followed by hygienic rationing and justification of preventive measures.
Effect of The Garlic as Chelation Therapy in Reducing Lead and Cadmium Deposition on Suckling Mice
Authors: Das Bidyut , Hossain Md. Anwar , Islam Md. Siddiqul , Zullhash Md. Aktaruzzaman , Talha Md. Mowdudul Hasan , Munna Shahab Uddin , Sutradhar Dwija , Khan Ahasan Ullah 
Published: December 2024

The study was conducted on suckling mice to determine the effects of chelation therapy in reducing the deposition of lead (Pb) and cadmium (Cd). A total of 45 suckling mice were randomly divided into three main groups A (control), B, and C. Groups B and C contained Pb and Cd, respectively, at a concentration of 100 mg/kg bwt with 0, 1.70, 3.35, and 6.70% garlic given (B1, B2, B3, B4, and C1, C2, C3, C4). Mice exposed to Pb and Cd exhibited pronounced toxic symptoms along with a marked decrease in total erythrocyte and total leukocyte count, hemoglobin levels, and packed cell volume. Additionally, there is a significant increase in serum glutamate pyruvate transaminase (SGPT) and serum glutamate oxaloacetate transaminase (SGOT) levels. The mean body weight of mice of groups B4, and C4 was the highest among the treated groups. Groups B1 and C1, exposed to Pb and Cd without garlic, showed significant declines in all parameters. Group A (control) shows stable and normal SGOT and SGPT levels. Group C1, exposed to Cd without garlic, experiences the highest increases in both SGOT (98.53 U/L) and SGPT (132.83 U/L), indicating severe liver damage. The group treated with Pb and Cd showed a significant reduction in total erythrocyte count, packed cell volume, and hemoglobin levels after 42-d of treatment. However, mice treated with a combination of Pb, Cd, and 6.70% garlic exhibited nearly normal levels of hematological and biochemical parameters. SGPT and SGOT levels were significantly decreased in all treated groups along with garlic. This experiment demonstrates that garlic possesses both protective and curative effects against Pb and Cd toxicity.
Effectiveness and safety of TNF-α inhibitors and il-6 pathway antagonists for refractory Takayasu arteritis
Authors: Logina V. E. , Bulanov N. M. , Efimova A. A. , Vlasova N. P. , Makarova K. V. , Novikov P. I. , Moiseev S. V. 
Published: December 2024

Standard therapy for Takayasu arteritis (TA) usually comprises glucocorticoids in combination with cytotoxic agents. However, despite ongoing therapy disease activity remains high in some patients. In these cases, biological therapy is prescribed.The aim – to evaluate the efficacy and safety of tumor necrosis factor α inhibitors (TNFi) and interleukin 6 (IL-6) pathway antagonists (anti-IL-6) therapy in TA patients refractory to conventional therapy.Subjects and methods. In this single center retrospective cohort study, we included 36 female adult patients aged from 20 to 57 years (54 courses of biological therapy) with TA, diagnosed in accordance with the ACR classification criteria (1990 and/or 2022) and/or Chapel Hill Consensus Conference (2012) definition. All patients were on biologics due to resistance to corticosteroids and cytotoxic agents.Results. A total of 54 courses of TNFi (n=29) and anti-IL-6 (n=25) inhibitors were analyzed. The median duration of biological therapy was 14 (9; 32) months, with a median duration of 14 (8; 32) months for TNFi and 13 (7; 32) months for anti-IL-6. The remission rate showed no significant difference between TNFi (79%) and anti-IL-6 (84%; p=0.736) treatment groups. The incidence of relapses was higher with TNFi, although the difference between groups did not reach statistical significance (36% and 14%, respectively; p=0.291). Relapse was established after 15 (10; 22) weeks for TNFi and after 22 (13; 31) weeks for anti-IL-6 (p=0.919). TNFi and anti-IL-6 had a comparable steroid-sparing effect: the median dose of GC in terms of prednisolone decreased from 13 to 8 mg (p=0.009), and from 15 to 8 mg (p=0.026), respectively. Factors associated with achieving TA remission were assessed using a logistic regression model. None of the parameters (age at the start of biological therapy, duration of disease before the start of biological therapy, class of biological therapy) were associated with achieving remission of TA. Adverse events (AEs) occurred in 22% of cases resulting in therapy discontinuation in 13% of patients.Conclusion. Our study demonstrated the high effectiveness of TNFi and anti-IL-6 in patients with refractory to conventional immunosuppressive therapy TA: remission was achieved in 80% of cases, allowing for a reduction in glucocorticoid dosage. The safety profile of TNFi and antiIL-6 was acceptable. However, AEs occurred slightly more frequently in the TNFi group.
PENYULUHAN POLA PIKIR WAWASAN KRISTEN TENTANG LGBT PADA MAHASISWA JURUSAN PENDIDIKAN IPS UNIVERSITAS PELITA HARAPAN DAN GURU SD GMIM LELEMA KABUPATEN MINAHASA SELATAN
Authors: Walukow Devy Stany , Silitonga Roedy 
Published: December 2024

Kemudahan memperoleh informasi tentang LGBT dan bahkan menjadi “life style” sebagian masyarakat dewasa ini menimbulkan keprihatinan dunia pendidikan. Pemahaman gender yang mengatasnamakan HAM dapat membuka ruang terbentuknya LGBT di Indonesia. Kondisi ini menghancurkan konsep manusia ciptaan Tuhan yang dibedakan laki-laki dan perempuan saja. Namun demikian penderita LGBT sebagai individu ciptaan Tuhan dan telah jatuh ke dalam dosa, tidak boleh mendapat perlakuan yang tidak manusiawi. Penderita LGBT perlu dirangkul dengan sentuhan “kasih” dalam bentuk edukasi untuk membawa penderita LGBT pada konstruksi ciptaan Allah. Konsep ini perlu dipahami oleh calon guru IPS Universitas Pelita Harapan dan guru Sekolah Dasar GMIM Lelema di Kabupaten Minahasa Selatan sebagai pengemban pembentukan karakter. Ternyata LGBT dikaitkan dengan konsep gender belum dipahami secara tepat. Bervariasinya pemikiran gender dalam ilmu sosial tentang gender membutuhkan arahan dari wawasan Kristen. Kegiatan dilaksanakan dalam bentuk tatap muka virtual melalui zoom dan dilakukan Pre-Test dan Post-Test.
Современные направления преподавания английского языка
Authors: Абдуллаева М.И. , Гусейнова С.А. 
Published: December 2024

Актуальность исследования заключается в необходимости разработки эффективных методов запоминания английской лексики, которые увеличивают мотивацию студентов и учитывают современные образовательные потребности. Цель исследования – изучить и обосновать подходы к обучению английской лексики, основанные на использовании этимологии, интересных фактов и ассоциативного мышления. Рассмотрены традиционные и инновационные методы преподавания, включая грамматико-переводческий и коммуникативный подходы, а также мультимедийные инструменты. Раскрыты преимущества использования ассоциаций между английскими и русскими словами, а также интеграция необычных фактов и контекстного изучения. Выявлены ограничения существующих методов и доказана эффективность подходов, основанных на интересных фактах и этимологии, через проведенные эксперименты. Обоснована необходимость включения инновационных методов в образовательные программы для повышения результативности обучения и мотивации студентов.
The relevance of the research lies in the need to develop effective methods of memorizing English vocabulary that increase students’ motivation and take into account modern educational needs. The purpose of the study is to study and substantiate approaches to teaching English vocabulary based on the use of etymology, interesting facts and associative thinking. Traditional and innovative teaching methods, including grammar-translation and communication approaches, as well as multimedia tools, are considered. The advantages of using associations between English and Russian words are revealed, as well as the integration of unusual facts and contextual study. The limitations of existing methods are revealed and the effectiveness of approaches based on interesting facts and etymology is proved through experiments. In conclusion, the need to include innovative methods in educational programs to increase the effectiveness of learning and motivation of students is justified.
Терминологическая основа устойчивого развития сельских территорий
Authors: Чеботарева Е.Н. 
Published: December 2024

В статье проанализирован терминологический аппарат устойчивого развития сельских территорий, который играет ключевую роль в формировании концептуальных подходов, стратегий и практик, направленных на сбалансированное социальное, экономическое и экологическое развитие сельских сообществ. Рассмотрены основные аспекты устойчивого развития: социальная, экономическая и экологическая устойчивость. Описываются уникальные особенности сельских территорий – географическая специфичность и экономическая деятельность, требующие специализированного подхода к разработке политики. Выделены современные тенденции, включая цифровизацию, экологизацию, адаптацию к изменениям климата и социальную инклюзивность. Отмечена необходимость междисциплинарного подхода и адаптации терминологии к локальным и глобальным условиям. Исследование подчеркивает значимость создания методологической базы для эффективного управления процессами, направленными на долгосрочное улучшение качества жизни и устойчивость сельских территорий.
The article forms and analyzes the terminological apparatus of sustainable rural development, which plays a key role in the formation of conceptual approaches, strategies and practices aimed at balanced social, economic and environmental development of rural communities. The study analyzes the main aspects of sustainable development: social sustainability, economic sustainability and environmental sustainability. The unique features of rural areas are considered – geographical specificity and economic activity that require a specialized approach to policy development. Current trends are highlighted, including digitalization, greening, adaptation to climate change and social inclusion. The need for an interdisciplinary approach and the adaptation of terminology to local and global conditions is noted. The study highlights the importance of creating a methodological framework for effective management of processes aimed at long-term improvement of the quality of life and sustainability of rural areas.
Математическое моделирование в оптимизации бюджетного планирования муниципалитетов
Authors: Савченко М.М. , Сергеева К.С. , Лытнев Н.Н. 
Published: December 2024

Исследование посвящено применению математического моделирования в оптимизации бюджетного планирования муниципалитетов. Дается анализ применения таких математических моделей, как линейное и динамическое программирование с целью повышения эффективности управления бюджетными ресурсами. Выделяются аспекты бюджетного планирования, включая необходимость учета факторов риска, прогнозирование доходов и расходов, а также минимизацию бюджетных дефицитов. Представлены методы математического моделирования, включая построение математических моделей с учетом параметров доходов, расходов и бюджетного баланса. Модели содержат ограничения, обеспечивающие реалистичность расчетов и возможность их применения в условиях нестабильности. Основные выводы исследования демонстрируют, что математическое моделирование позволяет улучшить прозрачность и точность бюджетного процесса, способствуя разработке долгосрочных стратегий, адаптированных к внутренним и внешним вызовам.
The study is devoted to the application of mathematical modeling in optimizing the budget planning of municipalities. The analysis of the application of mathematical models such as linear and dynamic programming in order to improve the efficiency of budget resource management is given. Aspects of budget planning are highlighted, including the need to take into account risk factors, forecasting income and expenses, as well as minimizing budget deficits. Mathematical modeling methods are presented, including the construction of mathematical models taking into account the parameters of income, expenses and budget balance. The models contain limitations that ensure the realism of calculations and the possibility of their application in conditions of instability. The main conclusions of the study demonstrate that mathematical modeling can improve the transparency and accuracy of the budget process, contributing to the development of long-term strategies adapted to internal and external challenges.
Интеграция клипового мышления в предпринимательское образование: теория, практика и стратегии адаптации
Authors: Карпова Л.А. 
Published: December 2024

В статье анализируется процесс интеграции клипового мышления в систему предпринимательского образования. Освещаются теоретические основы, практическое применение и стратегии адаптации к быстро меняющемуся бизнес-ландшафту. Исследование подчеркивает необходимость развития критического мышления и стратегического анализа среди предпринимателей для повышения их конкурентоспособности и инновационного потенциала. Предложены авторские методики и рекомендации по усовершенствованию образовательных программ, которые помогут предпринимателям эффективно адаптироваться к новым условиям.
This article explores the integration of clip thinking into the entrepreneurial education system. It covers theoretical foundations, practical applications, and adaptation strategies to rapidly changing business landscapes. The study emphasizes the necessity of developing critical thinking and strategic analysis among entrepreneurs to enhance their competitiveness and innovative potential. Authorial methodologies and recommendations for enhancing educational programs are proposed, which will help entrepreneurs effectively adapt to new conditions.
Развитие инструментария на основе бенчмаркинга в управленческом учете
Authors: Кузина А.Ф. , Аблезова Е.А. , Огибенина А.А. 
Published: December 2024

В статье рассматривается концепция бенчмаркинга как ключевой инструмент в управленческом учете коммерческих организаций. Подробно анализируются методы и подходы к сравнительному оцениванию эффективности бизнес-процессов, ключевых показателей и стратегий. Подчеркивается значимость бенчмаркинга в контексте повышения конкурентоспособности, оптимизации ресурсов и формирования комплексного подхода к управлению. Исследуется связь между анализом лучших практик и принятием обоснованных управленческих решений. Результаты работы могут быть полезны как для практических менеджеров, так и для ученых, занимающихся вопросами управления и экономической эффективности. Также даны рекомендации по реализации процесса бенчмаркинга в организациях, стремящихся к постоянному совершенствованию и инновациям.
The article discusses the concept of benchmarking as a key tool in the management accounting of commercial organizations. Methods and approaches to comparative evaluation of the effectiveness of business processes, key indicators and strategies are analyzed in detail. The authors emphasize the importance of benchmarking in the context of increasing competitiveness, optimizing resources and developing an integrated management approach. The relationship between the analysis of best practices and the adoption of sound management decisions is investigated. The results of the work can be useful both for practical managers and for scientists dealing with management and economic efficiency. The article also provides recommendations for the implementation of the benchmarking process in organizations seeking continuous improvement and innovation.