bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Organic–Inorganic Perovskitoid with Zwitterion Cysteamine Linker and its Crystal–Crystal Transformation to Ruddlesden‐Popper Phase
Authors: Kour Prachi , Chenna Reddy Mallu , Pal Shiv , Sidhik Siraj , Das Tisita , Pandey Padmini , Mukherjee Shatabdi Porel , Chakraborty Sudip , Mohite Aditya D. , Ogale Satishchandra 
Published: June 2021

AbstractWe demonstrate synthesis of a new low‐D hybrid perovskitoid (a perovskite‐like hybrid halide structure, yellow crystals, P21/n space group) using zwitterion cysteamine (2‐aminoethanethiol) linker, and its remarkable molecular diffusion‐controlled crystal‐to‐crystal transformation to Ruddlesden‐Popper phase (Red crystals, Pnma space group). Our stable intermediate perovskitoid distinctly differs from all previous reports by way of a unique staggered arrangement of holes in the puckered 2D configuration with a face‐sharing connection between the corrugated‐1D double chains. The PL intensity for the yellow phase is 5 orders higher as compared to the red phase and the corresponding average lifetime is also fairly long (143 ns). First principles DFT calculations conform very well with the experimental band gap data. We demonstrate applicability of the new perovskitoid yellow phase as an excellent active layer in a self‐powered photodetector and for selective detection of Ni2+ via On‐Off‐On photoluminescence (PL) based on its composite with few‐layer black phosphorous.
Programmable Chromism and Photoluminescence of Spiropyran‐Based Liquid Crystalline Polymer with Tunable Glass Transition Temperature
Authors: Hu Wei , Sun Chang , Ren Yunxiao , Qin Shengyu , Shao Yu , Zhang Lanying , Wu Yu , Wang Qian , Yang Huai , Yang Dengke 
Published: June 2021

AbstractSpiropyran‐based materials (SPBMs) can give responses to the stimulations induced by the light, heat, force, or pH, which have been used as triggers for many smart materials. Here, a cross‐linkable SPBM containing mesogenic‐units is synthesized, which is pale‐colored, non‐photoluminescent and non‐mesogenic at a spiro form, but dark‐colored, photoluminescent, and mesogenic at a merocyanine form. Moreover, the dynamic interconversion behavior of the form in the different chemical environments are distinct. Liquid crystalline polymers (LCPs) containing the SPBMs cross‐linked via visible light, own a photoswitchable glass transition temperature (Tg) and retain the switchable property; however, the SPBMs cross‐linked via UV light will be locked at the MC state, because the molecular movement was frozen at the room temperature lower than the given Tg of the LCP. Thus, programmable chromism and photoluminescence based on the tunable Tg can be endowed to the functional materials prepared from the SPBMs.
Ein zur Basenkatalyse befähigtes Ligationsauxiliar ermöglicht die cysteinfreie native chemische Ligation an anspruchsvollen Verknüpfungsstellen
Authors: Fuchs Olaf , Trunschke Sebastian , Hanebrink Hendrik , Reimann Marc , Seitz Oliver 
Published: June 2021

AbstractLigationsauxiliare werden in der chemischen Proteinsynthese eingesetzt, um den Anwendungsbereich der nativen chemischen Ligation (NCL) über Cystein hinaus zu erweitern. An sterisch anspruchsvollen Ligationsstellen erweisen sich Auxiliar‐vermittelte Ligationen allerdings als schwierig. Oft akkumuliert das im Thiolaustauschschritt der NCL gebildete Thioester‐Intermediat, da der anschließende S→N‐Acyltransfer nur sehr langsam abläuft. In dieser Arbeit stellen wir die 2‐Mercapto‐2‐(pyridin‐2‐yl)ethyl (MPyE)‐Gruppe als das erste Auxiliar vor, welches in der Lage ist, die Ligationsreaktion durch interne Katalyse zu unterstützen. Bemerkenswerterweise liefert das MPyE‐Auxiliar auch dann nützliche Reaktionsraten, wenn Prolin oder eine β‐verzweigte Aminosäure an der Verknüpfung beteiligt sind. Quantenchemische Rechnungen deuten darauf hin, dass der Pyridin‐Stickstoff im geschwindigkeitsbestimmenden Protonentransferschritt als eine intramolekulare Base agiert. Das Auxiliar wird in nur zwei Schritten hergestellt und durch reduktive Alkylierung in das Peptid eingeführt. Die Abspaltung des Auxiliars erfolgt durch Behandlung mit TCEP/Morpholin in Gegenwart eines MnII‐Komplexes als Radikalstarter. Die Synthese eines de novo designten 99mer‐Peptids und eines 80 Aminosäuren langen MUC1‐Peptids demonstrieren die Nützlichkeit des MPyE‐Auxiliars.
Ein vielseitiges Silber(I)‐pentafluorooxosulfat‐Reagenz für die Synthese von OSF5‐Verbindungen
Authors: Haupt Axel , Duvinage Daniel , Lork Enno , Ponomarenko Maksym , Röschenthaler Gerd‐Volker 
Published: June 2021

AbstractHiermit berichten wir über die Herstellung von Silber(I)‐pentafluorooxosulfat aus kommerziell erhältlichem AgF und OSF4. Die Verbindung ist überraschend stabil in MeCN‐Lösungen. Darüber hinaus lässt sie sich durch Zugabe von 2,2′‐Bipyridin‐Liganden stabilisieren. Ausgehend von Lösungen des Silber(I)‐Salzes wurden OSF5‐Komplexe mit NiII‐, CuI‐ und CuII‐Zentren erhalten. Weiterhin konnte gezeigt werden, dass AgOSF5 grundsätzlich in der Lage ist, den Transfer von OSF5‐Gruppen an Arine zu vermitteln und somit eine neue und sichere Methode zur Herstellung OSF5‐substituierter Aromaten zu eröffnen. Die Röntgenstrukturanalyse ausgewählter Übergangsmetall‐OSF5‐Verbindungen offenbarte verzerrt oktaedrische [OSF5]−‐Anionen, die durch eine Vielzahl an Wasserstoffbrücken stabilisiert sind.
The Hydrates of TEMPO: Water Vibrations Reveal Radical Microsolvation
Authors: Brás Elisa M. , Fischer Taija L. , Suhm Martin A. 
Published: June 2021

AbstractAn organic radical monohydrate complex is detected in vacuum isolation at low temperature by FTIR supersonic jet spectroscopy for the first time. It is shown to exhibit a rich conformational and vibrational coupling dynamics, which can be drastically reduced by appropriate isotope substitution. Its detection with a new gas recycling infrared spectrometer demonstrates the thermal metastability of the gaseous TEMPO radical even under humid gas conditions. Compared to its almost isoelectronic and isostructural, closed shell ketone analogue, the hydrogen bond of the solvating water is found to be less directional, but stronger and more strongly downshifting the bonded water OH stretch vibration. A second solvent water directs the first one into a metastable hydrogen bond position to solvate the nitrogen center and the first water at the same time.
Electro‐mediated PhotoRedox Catalysis for Selective C(sp3)–O Cleavages of Phosphinated Alcohols to Carbanions
Authors: Tian Xianhai , Karl Tobias A. , Reiter Sebastian , Yakubov Shahboz , de Vivie‐Riedle Regina , König Burkhard , Barham Joshua P. 
Published: June 2021

AbstractWe report a novel example of electro‐mediated photoredox catalysis (e‐PRC) in the reductive cleavage of C(sp3)−O bonds of phosphinated alcohols to alkyl carbanions. As well as deoxygenations, olefinations are reported which are E‐selective and can be made Z‐selective in a tandem reduction/photosensitization process where both steps are photoelectrochemically promoted. Spectroscopy, computation, and catalyst structural variations reveal that our new naphthalene monoimide‐type catalyst allows for an intimate dispersive precomplexation of its radical anion form with the phosphinate substrate, facilitating a reactivity‐determining C(sp3)−O cleavage. Surprisingly and in contrast to previously reported photoexcited radical anion chemistries, our conditions tolerate aryl chlorides/bromides and do not give rise to Birch‐type reductions.
Nanoscale Analysis of Historical Paintings by Means of O‐PTIR Spectroscopy: The Identification of the Organic Particles in L′Arlésienne (Portrait of Madame Ginoux) by Van Gogh
Authors: Beltran Victoria , Marchetti Andrea , Nuyts Gert , Leeuwestein Margje , Sandt Christophe , Borondics Ferenc , De Wael Karolien 
Published: June 2021

AbstractOptical‐photothermal infrared (O‐PTIR) spectroscopy is a recently developed technique that provides spectra comparable to traditional transmission FTIR spectroscopy with nanometric spatial resolution. Hence, O‐PTIR is a promising candidate for the analysis of historical paintings, as well as other cultural heritage objects, but its potential has not yet been evaluated. This work presents the first application of O‐PTIR to the analysis of cultural heritage, and in particular to an extremely small fragment from Van Gogh's painting L′Arlésienne (portrait of Madame Ginoux). The striking results obtained, including the detection of geranium lake pigments as well as the complete analysis of the stratigraphy, failed with other state‐of‐the‐art techniques, highlight the potential of this method. The integration of O‐PTIR to the study of cultural heritage opens to the possibility of decreasing the amount of sample extracted, therefore contributing to the preservation of the integrity of artworks while providing a complete characterization of the materials.
A Versatile Silver(I) Pentafluorooxosulfate Reagent for the Synthesis of OSF5 Compounds
Authors: Haupt Axel , Duvinage Daniel , Lork Enno , Ponomarenko Maksym , Röschenthaler Gerd‐Volker 
Published: June 2021

AbstractHerein, we report the preparation of silver(I) pentafluorooxosulfate from commercially available AgF and OSF4. The compound is surprisingly stable in a MeCN solution. Apart from that, AgOSF5 has been stabilised by the addition of 2,2′‐bipyridine ligands. Starting from solutions of the unstabilised silver(I) salt, OSF5 complexes with NiII, CuI, and CuII‐centres have been obtained. In addition, AgOSF5 has proven to be generally capable of mediating the transfer of OSF5 groups to aryne moieties, thus furnishing a new and safe method for the preparation of OSF5‐substituted arenes. X‐ray crystal structure analysis of selected transition‐metal OSF5 compounds have revealed distorted octahedral [OSF5]− anions which are extensively stabilised by hydrogen bonding.
Porous 2D and 3D Covalent Organic Frameworks with Dimensionality‐Dependent Photocatalytic Activity in Promoting Radical Ring‐Opening Polymerization
Authors: Wang Kaixuan , Kang Xing , Yuan Chen , Han Xing , Liu Yan , Cui Yong 
Published: June 2021

AbstractDimensionality is a fundamental parameter to modulate the properties of solid materials by tuning electronic structures. Covalent organic frameworks (COFs) are a prominent class of porous crystalline materials, but the study of dimensional dependence on their physicochemical properties is still lacking. Herein we illustrate photocatalytic performances of N,N‐diaryl dihydrophenazine (PN)‐based COFs are heavily dependent on the structural dimensionality. Six isostructural imine‐bonded 2D‐PN COFs and one 3D‐PN COF were prepared. All can be heterogeneous photocatalysts to promote radical ring‐opening polymerization of vinylcyclopropanes (VCPs), which typically produces polymers with a combination of linear (l) and cyclic (c) repeat units. The 2D‐PN COFs have much higher catalytic activity than the 3D‐PN COF, allowing the efficient synthesis of poly(VCPs) with controlled molecular weight, low dispersity and high l/c selectivity (up to 97 %). The improved performance can be ascribed to the 2D structure which has a larger internal surface area, more catalytically active sites, higher photosensitizing ability and photoinduced electron transfer efficiency.
Experimental study on bituminous coal blending in a down‐fired boiler with anthracite combustion system under low load
Authors: Yang Xigang , Chen Guoqing , Huang Linbin , Gu Shijun , Li Changsong , Zhang Yong , Jin Baosheng 
Published: June 2021

AbstractThe industrial experiments were carried out to study the bituminous coal blending in a 660‐MWe supercritical down‐fired boiler with anthracite combustion system under low load. The influence of the bituminous coal ratio on the boiler thermal efficiency, flue gas temperature, flue gas species, and heat transfer of various heating surfaces was analyzed in detail. The ignition distances of three experimental coals were measured, and the influence mechanism of bituminous coal blending on the combustion, heat transfer, and NOx emission in the furnace was proposed. The results show that increasing the bituminous coal blending ratio is beneficial to reduce NOx emissions. However, it leads to the rise of the exhaust gas temperature and the decrease of the boiler efficiency, which can be ascribed to the large amount of the cold primary air sent into the pulverizing system to control the air pulverized coal flow temperature at the mill outlet. The ignition distances of three experimental coals are different. The ignition distance from short to long follows the following order, that is, bituminous coal, lean coal, and anthracite. The earlier ignition of the bituminous coal leads to a sharp rise in the temperature of the airflow at the burner nozzle outlet, a rapid expansion of the airflow volume, and a sharp attenuation of the airflow rigidity, resulting in a short flame downward penetration depth and the upward movement of the flame center in the furnace. As the bituminous coal is blended, the change of the flame center and the flame fullness in the furnace affects the flue gas temperature distribution. Similarly, the change of the radiant heat transfer intensity and the convective heat transfer intensity affects the heat absorption distribution of the heating surface in the furnace.
Phase IIa Global Study Evaluating Rituximab for the Treatment of Pediatric Patients With Granulomatosis With Polyangiitis or Microscopic Polyangiitis
Authors: Brogan Paul , Yeung Rae S. M. , Cleary Gavin , Rangaraj Satyapal , Kasapcopur Ozgur , Hersh Aimee O. , Li Suzanne , Paripovic Dusan , Schikler Kenneth , Zeft Andrew , Bracaglia Claudia , Eleftheriou Despina , Pordeli Pooneh , Melega Simone , Jamois Candice , Gaudreault Jacques , Michalska Margaret , Brunetta Paul , Cooper Jennifer C. , Lehane Patricia B. ,   the PePRS Study Group
Published: June 2021

ObjectiveTo assess the safety, tolerability, pharmacokinetics, and efficacy of rituximab (RTX) in pediatric patients with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA).MethodsThe Pediatric Polyangiitis Rituximab Study was a phase IIa, international, open‐label, single‐arm study. During the initial 6‐month remission‐induction phase, patients received intravenous infusions of RTX (375 mg/m2 body surface area) and glucocorticoids once per week for 4 weeks. During the follow‐up period, patients could receive further treatment, including RTX, for GPA or MPA. The safety, pharmacokinetics, pharmacodynamics, and exploratory efficacy outcomes with RTX were evaluated.ResultsTwenty‐five pediatric patients with new‐onset or relapsing disease were enrolled at 11 centers (19 with GPA [76%] and 6 with MPA [24%]). The median age was 14 years (range 6–17 years). All patients completed the remission‐induction phase. During the overall study period (≤4.5 years), patients received between 4 and 28 infusions of RTX. All patients experienced ≥1 adverse event (AE), mostly grade 1 or grade 2 primarily infusion‐related reactions. Seven patients experienced 10 serious AEs, and 17 patients experienced 31 infection‐related AEs. No deaths were reported. RTX clearance correlated with body surface area. The body surface area–adjusted RTX dosing regimen resulted in similar exposure in both pediatric and adult patients with GPA or MPA. Remission, according to the Pediatric Vasculitis Activity Score, was achieved in 56%, 92%, and 100% of patients by months 6, 12, and 18, respectively.ConclusionIn pediatric patients with GPA or MPA, RTX is well tolerated and effective, with an overall safety profile comparable to that observed in adult patients with GPA or MPA who receive treatment with RTX. RTX is associated with a positive risk/benefit profile in pediatric patients with active GPA or MPA.
Characterization of Chinese hamster ovary cell culture feed media precipitate
Authors: Hoang Duc , Galbraith Shaun , Kuang Bingyu , Johnson Amy , Yoon Seongkyu 
Published: June 2021

AbstractProcess intensification of monoclonal antibody production is leading to more concentrated feed media causing issues with precipitation of solids from the media solution. This results in processing problems since components in the precipitate are no longer in solution, changing the media composition and leading to variability in cell culture performance. The goal of this work is to characterize the feed media precipitate, and in particular to identify the precipitated components so that mitigation strategies can be developed. From the conducted analysis, the precipitate was predominately found to be organic and was analyzed with liquid chromatography‐mass spectrometry and inductively coupled plasma‐optical emission spectroscopy (ICP‐OES) to identify the constituent components. Up to ten amino acids were identified with tyrosine (approximately 77 wt.%) and phenylalanine (approximately 4 wt.%) being the most prevalent amino acids. Elemental analysis with ICP‐OES revealed that inorganic components were accounted for less than one weight percentage of the solid precipitate with metal sulfates being the predominant inorganic components.
A mixed‐methods study of cyclin‐dependent kinase 4 and 6 inhibitor symptom burden and quality of life among metastatic breast cancer patients and providers
Authors: Oswald Laura B. , Arredondo Brandy , Kadono Mika , Martinez‐Tyson Dinorah , Meade Cathy D. , Penedo Frank , Antoni Michael H. , Soliman Hatem , Costa Ricardo L. B. , Jim Heather S. L. 
Published: June 2021

AbstractBackgroundCyclin‐dependent kinase 4 and 6 (CDK4/6) inhibitor targeted therapies dramatically improve survival outcomes for metastatic breast cancer (MBC), but they are associated with significant symptom burden that can impact patients’ health‐related quality of life (HRQOL) and treatment outcomes. This study is the first to describe CDK4/6 inhibitor symptoms from the lived perspectives of MBC patients taking CDK4/6 inhibitors and healthcare providers involved in MBC care. This study also explored patients’ symptom management and HRQOL concerns, and gathered feedback about developing supportive interventions for MBC.MethodsMBC patients taking CDK4/6 inhibitors (N = 20) and MBC healthcare providers (N = 12) participated in semi‐structured interviews that were analyzed for qualitative themes. MBC patients completed surveys about HRQOL, symptoms, and unmet needs.ResultsPatient and provider perceptions of CDK4/6 inhibitor symptoms did not align with patients perceiving symptoms as more burdensome. Patients reported that supportive resources (e.g., support groups, blogs) that are not specific to MBC do not adequately meet their needs. Patients and providers were enthusiastic about developing supportive interventions specifically for MBC and offered considerations for designing such interventions.ConclusionsFindings highlight differences in perceptions of CDK4/6 inhibitor symptom burden between MBC patients and providers. Results will inform the development of supportive interventions to assist MBC patients in managing CDK4/6 inhibitor symptom burden and maintaining HRQOL. Such interventions could also improve treatment outcomes.
A rare case of bilateral double incisors; Early orthodontic management
Authors: Yassaei Soghra , Sharifi Mohadeseh , Ebrahiminik Zahra 
Published: June 2021

AbstractA safe and suitable approach in the treatment of unusual malformed anterior maxillary teeth would be to accept a birooted fused incisor as two central teeth by moving it across the midpalatal suture and improve the frontal esthetics.
A fast‐growing schwannoma of the tongue in a 15‐year‐old Iranian male: Review of literature and case report
Authors: Agha‐Hosseini Farzaneh , Moosavi Mahdieh‐Sadat , Aminishakib Pouyan , Yousefian Marzieh 
Published: June 2021

AbstractSchwannoma can be included in the list of differential diagnoses of tongue masses but seems to be a rare finding in the Iranian population. The current case was presented as an exophytic nodular sessile mass which was growing fast.
Idiopathic intracranial hypertension with juvenile idiopathic arthritis‐associated uveitis: A case report
Authors: Alkoht Asaad , Alhariry Huda , Hanafi Ibrahem , Aboud Majed 
Published: June 2021

AbstractA 14‐year‐old girl with juvenile idiopathic arthritis (JIA)‐associated uveitis who also had optic disc edema, was later diagnosed with Idiopathic intracranial hypertension (IIH). To our knowledge, this is the fifth case of the coexistence of uveitis and IIH among children, and the only one with no obvious risk factors for IIH.
Sudden rupture of small aneurysm of the radial artery in a patient with COVID‐19 pneumonia
Authors: Mazzaccaro Daniela , Giannetta Matteo , Malacrida Giovanni , Zilio Dino , Modafferi Alfredo , Righini Paolo , Marrocco‐Trischitta Massimiliano M. , Vaienti Luca , Nano Giovanni 
Published: June 2021

AbstractIn patients with COVID‐19, even small radial aneurysm may suddenly rupture.
Diagnostics of Torsade de Pointes in an oncohematology patient: A case report
Authors: Bilmakhanbetova Ainur , Zhakhina Gulnur , Beisenbay Meruyert , Marat Daulet 
Published: June 2021

AbstractComplex heart rhythm disturbances due to cardiotoxicity may not be identified in time, and this may have an unfavorable outcome for patients. Holter monitoring can be a solution to prevent sudden cardiac death of oncohematology patients.
Dohsa‐hou intervention for reciprocal interpersonal interaction for a girl with Kabuki syndrome and autism spectrum disorder
Authors: Kawano Juri , Fujino Haruo 
Published: June 2021

AbstractAlthough available evidence for psychosocial treatment for patients with Kabuki syndrome is limited, Dohsa‐hou, a psychomotor therapy, could be a treatment option for autism spectrum disorder associated with the disorder.
Successful management of therapy‐related chronic myelomonocytic leukemia with cytarabine, aclarubicin, and azacitidine following tegafur/gimeracil/oteracil
Authors: Nakako Soichiro , Takakuwa Teruhito , Ichimura Hirona , Okamura Hiroshi , Nanno Satoru , Nishimoto Mitsutaka , Nakashima Yasuhiro , Koh Hideo , Hino Masayuki , Nakamae Hirohisa 
Published: June 2021

AbstractA 55‐year‐old man was diagnosed with therapy‐related chronic myelomonocytic leukemia (t‐CMML) after exposure to tegafur/gimeracil/oteracil. Although he was refractory to hydroxyurea and low‐dose cytarabine, combination therapy with cytarabine, aclarubicin and azacitidine (CA‐AZA) provided good disease control, and he underwent allogeneic stem cell transplantation. This report has two key massages. First, tegafur/gimeracil/oteracil may have a potential risk of developing t‐CMML. Second, CA‐AZA therapy may be considered as a therapeutic option for patients with t‐CMML.
May‐Thurner syndrome: A cause of unexplained unilateral leg edema
Authors: Tago Masaki , Fujiwara Motoshi , Tokushima Yoshinori , Yamashita Shun , Aihara Hidetoshi 
Published: June 2021

AbstractPhysicians should be familiar with May‐Thurner syndrome, characterized by the compression of the left common iliac vein by the right common iliac artery and the vertebral body, resulting in pain and swelling of the left lower extremity and DVT. A 64‐year‐old woman presented with unexplained edema in the left lower extremity. Computed tomography with contrast enhancement revealed that the left common iliac vein was compressed and narrowed by the right common iliac artery and the vertebral body, leading to the diagnosis of May‐Thurner syndrome.
Twenty years' use of expanded polytetrafluoroethylene sheet for an artificial cardiac pacemaker
Authors: Yorita Kenji , Takahashi Junichi , Tano Kazutoshi , Ichikawa Yoichi , Hamaguchi Nobumasa , Yasui Wataru 
Published: June 2021

AbstractPhysicians can prolongedly use expanded polytetrafluoroethylene sheets for fixation of artificial cardiac pacemakers to avoid pacemaker lead displacement. The sheets can also be used to prevent implant rejection in patients with metal allergies.
Re‐exposure to immunotherapy in metastatic colon cancer: A case report
Authors: Hamre Tonje Riise , Stougaard Julie Kristine , Havelund Birgitte Mayland , Jensen Lars Henrik , Hansen Torben Frøstrup 
Published: June 2021

AbstractRe‐exposure to immunotherapy in metastatic colorectal cancer may be indicated in selected patients that previously benefitted from immunotherapy with tolerable irAEs.