bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient–provider discussion about emotional and social needs, mental health outcomes, and benefit finding among U.S. Adults living with cancer
Authors: Hong Young‐Rock , Yadav Sandhya , Suk Ryan , Khanijahani Ahmad , Erim Daniel , Turner Kea 
Published: May 2021

AbstractBackgroundA discussion about patient's nonmedical needs during treatment is considered a crucial component of high‐quality patient–provider communication. We examined whether having a patient–provider discussion about cancer patients’ emotional and social needs is associated with their psychological well‐being.MethodsUsing the 2016–2017 Medical Expenditure Panel Survey‐Experiences with Cancer Survivorship Supplement (MEPS–ECSS) data, we identified the cancer survivors in the United States (US) who reported having a detailed discussion about emotional and social needs during cancer care. We used multivariable logistic regression to assess the association between having a patient–provider discussion and the patients’ psychological well‐being outcomes (depressive symptoms, severe psychological distress, and worrying about cancer recurrence/worsening condition) and benefit finding experience after a cancer diagnosis.ResultsAmong 1433 respondents (equivalent to 13.8 million cancer survivors in the US), only 33.6% reported having a detailed patient–provider discussion about their emotional and social needs. Having a discussion was associated with 55% lower odds (odds ratio [OR], 0.45; 95% confidence interval [CI], 0.26–0.77) of having depressive symptoms and 97% higher odds (OR, 1.97; 95% CI, 1.46–2.66) of having benefit finding experience. There was no statistically significant association between patient–provider discussion and psychological distress or worrying about cancer recurrence/worsening.ConclusionDetailed patient–provider discussion about the cancer patients’ emotional and social needs was associated with a lower likelihood of depressive symptoms and a higher likelihood of experiencing benefit finding. These findings stress the importance of improving the patient–provider discussion about psychosocial needs in cancer survivorship.
The efficacy of radiofrequency ablation versus cryoablation in the treatment of single hepatocellular carcinoma: A population‐based study
Authors: Chen Lei , Ren Yanqiao , Sun Tao , Cao Yanyan , Yan Liangliang , Zhang Weihua , Ouyang Tao , Zheng Chuansheng 
Published: May 2021

AbstractBackgroundRadiofrequency ablation (RFA) is an effective treatment for single hepatocellular carcinoma (HCC), but it is difficult to use against tumors in some locations and often leads to incomplete ablation as a result of the heat‐sink effect. This study was conducted to evaluate the efficacy of cryoablation compared with that of RFA in the treatment of single HCC.MethodsThis retrospective study was conducted based on the Surveillance, Epidemiology, and End Results (SEER) database. From 2004 to 2015, patients aged 40 to 79 diagnosed with HCC were included in the study. A propensity score matching (PSM) model was used to reduce selection biases.ResultsBefore PSM, the median overall survival (mOS) and median cancer‐specific survival (mCSS) in the RFA group were slightly longer than those in the cryoablation group (p > 0.05). In the subgroup analysis, the mOS and mCSS of patients with tumor sizes <3, 3–5, and >5 cm who received RFA treatment were longer than those of patients given cryoablation treatment, but there was no significant difference (p > 0.05). Similar results were presented in patients at American Joint Committee on Cancer (AJCC) stages I and II. After PSM, the mOS and mCSS were slightly better in the RFA group than the cryoablation group but without significant differences. Univariate and multivariate analysis showed that cryoablation treatment was not an unfavorable factor for OS and CSS before or after PSM (p > 0.05). In the multivariable competing risk model, non‐cancer‐specific death was taken as a competing factor and cryoablation was also not unfavorable for the survival of patients before and after PSM (p > 0.05).ConclusionCryoablation is non‐inferior to RFA therapy for single HCC patients without lymph node invasion or distant metastasis.
Coating Porous MXene Films with Tunable Porosity for High‐Performance Solid‐State Supercapacitors
Authors: Abdolhosseinzadeh Sina , Heier Jakob , Zhang Chuanfang (John) 
Published: May 2021

AbstractTwo‐dimensional MXenes with their outstanding physical and chemical properties have been extensively used in numerous fields such as electrochemical energy storage, catalysis, and sensing. In these applications, high active surface area and facilitated diffusion of ions/atoms/molecules are crucial. While these features can be offered by porous films and structures, their fabrication at ambient conditions, especially with scalable methods such as printing and coating has proven to be quite challenging. Here, we have developed MXene inks containing a space‐holder agent, based on which porous films with tunable porosities can be easily coated. The whole fabrication process lasts only a few minutes and is carried out at room temperature and pressure, making it suitable for continuous scalable production. Films with different porosities (up to 80 %) have been coated and used for the fabrication of solid‐state microsupercapacitors with enhanced rate capability and improved capacitance (241 mF/cm2).
Self‐assembly of Amphiphilic Porphyrins To Construct Nanoparticles for Highly Efficient Photodynamic Therapy
Authors: Jiang Meiyu , Wu Jiasheng , Liu Weimin , Ren Haohui , Zhang Wenjun , Lee Chun‐Sing , Wang Pengfei 
Published: May 2021

AbstractHydrophobic photosensitizers greatly affect cell permeability and enrichment in tumors, but they cannot be used directly for clinical applications because they always aggregate in water, preventing their circulation in the blood and accumulation in tumor cells. As a result, amphiphilic photosensitizers are highly desirable. Although nanomaterial‐based photosensitizers can solve water solubility, they have the disadvantages of complicated operation, poor reproducibility, low drug loading, and poor stability. In this work, an efficient synthesis strategy is proposed that converts small molecules into nanoparticles in 100 % aqueous solution by molecular assembly without the addition of any foreign species. Three photosensitizers with triphenylphosphine units and ethylene glycol chains of different lengths, TPP−PPh3, TPP−PPh3−2PEG and TPP−PPh3−4PEG, were synthesized to improve amphiphilicity. Of the three photosensitizers, TPP−PPh3−4PEG is the most efficient (singlet oxygen yield: 0.89) for tumor photodynamic therapy not only because of its definite constituent, but also because its amphiphilic structure allows it to self‐assemble in water.
Spectroscopic and Molecular Docking Study of the Interaction between Neutral Re(I) Tetrazolate Complexes and Bovine Serum Albumin
Authors: Lazniewska Joanna , Agostino Mark , Hickey Shane M. , Parkinson‐Lawrence Emma , Stagni Stefano , Massi Massimiliano , Brooks Douglas A. , Plush Sally E. 
Published: May 2021

AbstractRe(I) complexes have potential in biomedical sciences as imaging agents, diagnostics and therapeutics. Thus, it is crucial to understand how Re(I) complexes interact with carrier proteins, like serum albumins. Here, two neutral Re(I) complexes were used (fac‐[Re(CO)3(1,10‐phenanthroline)L], in which L is either 4‐cyanophenyltetrazolate (1) or 4‐methoxycarbonylphenyltetrazole ester (2), to study the interactions with bovine serum albumin (BSA). Spectroscopic measurements, calculations of thermodynamic and Förster resonance energy transfer parameters, as well as molecular modelling, were performed to study differential binding between BSA and complex 1 and 2. Induced‐fit docking combined with quantum‐polarised ligand docking were employed in what is believed to be a first for a Re(I) complex as a ligand for BSA. Our findings provide a basis for other molecular interaction studies and suggest that subtle functional group alterations at the terminal region of the Re(I) complex have a significant impact on the ability of this class of compounds to interact with BSA.
Experimental Considerations for Operando Metal‐Ion Battery Monitoring using X‐ray Techniques
Authors: Saurel D. , Pendashteh A. , Jáuregui M. , Reynaud M. , Fehse M. , Galceran M. , Casas‐Cabanas M. 
Published: May 2021

AbstractOperando experiments represent a powerful tool for the monitoring of internal processes upon battery cycling that provide valuable insights regarding the fundamental electrochemical redox mechanisms and ageing phenomena in battery materials. However, obtaining high‐quality, representative and exploitable data from operando measurements requires careful control of many experimental parameters such as the cell configuration, the nature of the cell components, the electrode preparation approach, the optical/goniometer geometry, data acquisition protocols and data interpretation methodology. In this work we discuss the impact of all these factors in X‐ray scattering and spectroscopic techniques based on experimental results obtained from different electrode materials using a multifunctional electrochemical in situ cell developed at our laboratory.
Oncologic outcomes of human papillomavirus–associated oropharynx carcinoma treated with surgery alone: A 12‐institution study of 344 patients
Authors: Ryan William R. , Xu Mary J. , Ochoa Edgar , Plonowska‐Hirschfeld Karolina A. , Zebolsky Aaron L. , Ha Patrick K. , Bewley Arnaud F. , Mallen‐St. Clair Jonathan , Joshi Arjun S. , Coffey Charles S. , Faraji Farhoud , MacDonald Bridget V. , Houlton Jeffrey J. , Gobillot Theodore A. , Curry Joseph M. , Philips Ramez , Hackman Trevor G. , Richmon Jeremy D. , Holcomb Andrew J. , Coughlin Andrew M. , Panwar Aru , Smith Russell B. , Herberg Matthew E. , Fakhry Carole , Cognetti David M. 
Published: May 2021

BackgroundThe oncologic outcomes of surgery alone for patients with American Joint Committee on Cancer 7th edition (AJCC 7th) pN2a and pN2b human papillomavirus–associated oropharynx squamous cell carcinoma (HPV+OPSCC) are not clear.MethodsThe authors performed a 12‐institution retrospective study of 344 consecutive patients with HPV+OPSCC (AJCC 7th pT0‐3 N3 M0) treated with surgery alone with 6 months or more of follow‐up using univariate and multivariate analyses.ResultsThe 2‐year outcomes for the entire cohort were 91% (182 of 200) disease‐free survival (DFS), 100% (200 of 200) disease‐specific survival (DSS), and 98% (200 of 204) overall survival (OS). The 18 recurrences within 2 years were 88.9% (16 of 18) local and/or regional recurrences and 11.1% (2 of 18) distant metastases. Recurrences were not significantly associated with smoking, pT stage, or pN stage. The 16 patients with locoregional recurrences within 2 years all underwent successful salvage treatments (median follow‐up after salvage: 13.1 months), 43.8% (7 of 16) of whom underwent salvage surgery alone for a 2‐year overall salvage radiation need of 4.5% (9 of 200). The 2‐year outcomes for the 59 evaluable patients among the 109 AJCC 7th pT0‐2 N2a‐N2b patients with 1 to 3 pathologic lymph nodes (LNs) were as follows: local recurrence, 3.4% (2 of 59); regional recurrence, 8.4% (5 of 59); distant metastases, 0%; DFS, 88.1% (52 of 59); DSS, 100% (59 of 59); OS, 96.7% (59 of 61); and salvage radiation, 5.1% (3 of 59).ConclusionsWith careful selection, surgery alone for AJCC 7th pT0‐T2N0‐N2b HPV+OPSCC with zero to 3 pathologic LNs without perineural invasion, extranodal extension, or positive margins results in high DFS, DSS, OS, and salvage treatment success. Because of the short‐term follow‐up, these data support further investigation of treatment de‐escalation in this population.
Correlations between DW‐MRI and 18F‐FDG PET/CT parameters in head and neck squamous cell carcinoma following definitive chemo‐radiotherapy
Authors: Connor Steve , Sit Cherry , Anjari Mustafa , Szyszko Teresa , Dunn Joel , Pai Irumee , Cook Gary , Goh Vicky 
Published: May 2021

AbstractBackgroundPosttreatment diffusion–weighted magnetic resonance imaging (DW‐MRI) and 18F‐fluorodeoxygluocose (18F‐FDG) positron emission tomography (PET) with computed tomography (PET/CT) have potential prognostic value following chemo‐radiotherapy (CRT) for head and neck squamous cell carcinoma (HNSCC). Correlations between these PET/CT (standardized uptake value or SUV) and DW‐MRI (apparent diffusion coefficient or ADC) parameters have only been previously explored in the pretreatment setting.AimTo evaluate stage III and IV HNSCC at 12‐weeks post‐CRT for the correlation between SUVmax and ADC values and their interval changes from pretreatment imaging.MethodsFifty‐six patients (45 male, 11 female, mean age 59.9 + − 7.38) with stage 3 and 4 HNSCC patients underwent 12‐week posttreatment DW‐MRI and 18F‐FDG PET/CT studies in this prospective study. There were 41/56 patients in the cohort with human papilloma virus‐related oropharyngeal cancer (HPV OPC). DW‐MRI (ADCmax and ADCmin) and 18F‐FDG PET/CT (SUVmax and SUVmax ratio to liver) parameters were measured at the site of primary tumors (n = 48) and the largest lymph nodes (n = 52). Kendall's tau evaluated the correlation between DW‐MRI and 18F‐FDG PET/CT parameters. Mann‐Whitney test compared the post‐CRT PET/CT and DW‐MRI parameters between those participants with and without 2‐year disease‐free survival (DFS).ResultsThere was no correlation between DW‐MRI and 18F‐FDG PET/CT parameters on 12‐week posttreatment imaging (P = .455‐.794; tau = −0.075‐0.25) or their interval changes from pretreatment to 12‐week posttreatment imaging (P = .1‐.946; tau = −0.194‐0.044). The primary tumor ADCmean (P = .03) and the interval change in nodal ADCmin (P = .05) predicted 2‐year DFS but none of the 18F‐FDG PET/CT parameters were associated with 2‐year DFS.ConclusionsThere is no correlation between the quantitative DWI‐MRI and 18F‐FDG PET/CT parameters derived from 12‐week post‐CRT studies. These parameters may be independent biomarkers however in this HPV OPC dominant cohort, only selected ADC parameters demonstrated prognostic significance.Study was prospectively registered at http://www.controlled-trials.com/ISRCTN58327080
The convolutional neural network approach from electroencephalogram signals in emotional detection
Authors: Türk Ömer , Özerdem Mehmet Siraç 
Published: May 2021

SummaryAlthough brain‐computer interfaces (BCI) progress rapidly, the desired success has not been achieved yet. One of these BCI is to detect emotional states in humans. An emotional state is a brain activity consisting of hormonal and mental reasons in the face of events. Emotions can be detected by electroencephalogram (EEG) signals due to these activities. Being able to detect the emotional state from EEG signals is important in terms of both time and cost. In this study, a method is proposed for the detection of the emotional state by using EEG signals. In the proposed method, we aim to classify EEG signals without any transform (Fourier transform, wavelet transform, etc.) or feature extraction method as a pre‐processing. For this purpose, convolutional neural networks (CNNs) are used as classifiers, together with SEED EEG dataset containing three different emotional (positive, negative, and neutral) states. The records used in the study were taken from 15 participants in three sessions. In the proposed method, raw channel‐time EEG recordings are converted into 28 × 28 size pattern segments without pre‐processing. The obtained patterns are then classified in the CNN. As a result of the classification, three emotion performance averages of all participants are found to be 88.84%. Based on the participants, the highest classification performance is 93.91%, while the lowest classification performance is 77.70%. Also, the average f‐score is found to be 0.88 for positive emotion, 0.87 for negative emotion, and 0.89 for neutral emotion. Likewise, the average kappa value is 0.82 for positive emotion, 0.81 for negative emotion, and 0.83 for neutral emotion. The results of the method proposed in the study are compared with the results of similar studies in the literature. We conclude that the proposed method has an acceptable level of performance.
Turning Waste into Wealth: Remotely NIR Light‐Controlled Precious Metal Recovery by Covalently Functionalized Black Phosphorus
Authors: Zhang Siyu , Zhao Qing , Wang Dongsheng , Deng Shuo , Li Dengyu , Liu Xue , Wu Shuyao , Zhang Xuejiao , Xing Baoshan 
Published: May 2021

AbstractIt is a great challenge to refine precious metals from e‐wastes under mild conditions without hazardous reagents. Herein, black phosphorus (BP) was covalently functionalized with poly(N‐isopropylacrylamide) (PNIPAM) to obtain thermo/near‐infrared (NIR)‐responsive BP−P for precious metal recovery. Precious metals (Au, Ag, and Pd) with higher redox potentials than BP−P could be efficiently recovered by reduction‐driven enrichment. Taking Au as an example, the recovery process presented fast kinetics (<15 min), excellent selectivity, and high efficiency (≈98 %). Remote operation with NIR light could generate heat by BP, which induced the hydrophilic‐to‐hydrophobic transition of PNIPAM, allowing the spontaneous gathering, facile collection, and practical recycle of BP−P following Au extraction. Thanks to the unique features of BP−P, not only could high‐quality Au nanoparticles (20–30 nm) be economically extracted (cost: $0.731–1.222 g−1Au nanoparticles; 5–6 orders of magnitude lower than the market price), but also the formed BP−P‐Au nanocomposites have potential application in hydrogen evolution reaction.
Single‐stage pulse frequency controlled AC–AC resonant converter for different material vessel induction cooking applications
Authors: Khatroth Srinivas , Shunmugam Porpandiselvi 
Published: May 2021

SummaryThis paper presents a single‐stage AC–AC resonant converter configuration for different material vessel induction cooking. The proposed configuration features input power factor correction, boost operation, and integrated bridge inverter configuration for multiple loads. In this topology the inverter legs are operated at two different frequencies to power induction cooking loads of steel and aluminum vessels. The induction cooking loads are operated at frequencies closer to their respective resonant frequencies. The load powers are independently controlled by pulse frequency modulation (PFM) technique. The proposed topology eliminates the use of electromechanical switches. The proposed single‐stage AC–AC resonant converter configuration has been tested with two different vessels of steel and aluminum. The simulation and experimental results of the proposed configuration are in good agreement. This topology offers the advantages of low component count, high efficiency, and suitability for different material induction cooking.
Mutated GM‐CSF‐based CAR‐T cells targeting CD116/CD131 complexes exhibit enhanced anti‐tumor effects against acute myeloid leukaemia
Authors: Hasegawa Aiko , Saito Shoji , Narimatsu Shogo , Nakano Shigeru , Nagai Mika , Ohnota Hideki , Inada Yoichi , Morokawa Hirokazu , Nakashima Ikumi , Morita Daisuke , Ide Yuichiro , Matsuda Kazuyuki , Tashiro Haruko , Yagyu Shigeki , Tanaka Miyuki , Nakazawa Yozo 
Published: May 2021

AbstractObjectivesAs the prognosis of relapsed/refractory (R/R) acute myeloid leukaemia (AML) remains poor, novel treatment strategies are urgently needed. Clinical trials have shown that chimeric antigen receptor (CAR)‐T cells for AML are more challenging than those targeting CD19 in B‐cell malignancies. We recently developed piggyBac‐modified ligand‐based CAR‐T cells that target CD116/CD131 complexes, also known as the GM‐CSF receptor (GMR), for the treatment of juvenile myelomonocytic leukaemia. This study therefore aimed to develop a novel therapeutic method for R/R AML using GMR CAR‐T cells.MethodsTo further improve the efficacy of the original GMR CAR‐T cells, we have developed novel GMR CAR vectors incorporating a mutated GM‐CSF for the antigen‐binding domain and G4S spacer. All GMR CAR‐T cells were generated using a piggyBac‐based gene transfer system. The anti‐tumor effect of GMR CAR‐T cells was tested in mouse AML xenograft models.ResultsNearly 80% of the AML cells predominant in myelomonocytic leukaemia were found to express CD116. GMR CAR‐T cells exhibited potent cytotoxic activities against CD116+ AML cells in vitro. Furthermore, GMR CAR‐T cells incorporating a G4S spacer significantly improved long‐term in vitro and in vivo anti‐tumor effects. By employing a mutated GM‐CSF at residue 21 (E21K), the anti‐tumor effects of GMR CAR‐T cells were also improved especially in long‐term in vitro settings. Although GMR CAR‐T cells exerted cytotoxic effects on normal monocytes, their lethality on normal neutrophils, T cells, B cells and NK cells was minimal.ConclusionsGMR CAR‐T cell therapy represents a promising strategy for CD116+ R/R AML.
Memory binding and theta EEG during middle childhood
Authors: Rajan Vinaya , Cuevas Kimberly , Bell Martha Ann 
Published: May 2021

AbstractThe ability to bind together the contextual details associated with an event undergoes dramatic improvement during childhood. However, few studies have examined the neural correlates of memory binding encoding and retrieval during middle childhood. We examined age‐related encoding and retrieval differences using continuous electroencephalogram (EEG) measures in a sample of 6‐ and 8‐year‐olds. For the memory binding task, children were tested on memory for individual items (i.e., objects and backgrounds only) and combined object–backgrounds pairings (combination condition). Memory for individual item information was comparable across both age groups. However, younger children experienced greater difficulty (i.e., higher false alarm rate) in the combination condition. Theta (4–7 Hz) neuronal oscillations were analyzed to compare memory encoding and retrieval processes. Widespread retrieval‐related increases in theta band EEG power (compared with baseline and encoding‐related activation) were evident in both 6‐ and 8‐year‐olds. Regression analyses revealed that parietal theta EEG power during retrieval accounted for variability in memory binding performance. These findings suggest that theta rhythms are intricately linked to memory binding processes during middle childhood.
The DNA history of a lonely oak: Quercus humboldtii phylogeography in the Colombian Andes
Authors: Zorrilla‐Azcué Sofía , González‐Rodríguez Antonio , Oyama Ken , González Mailyn A. , Rodríguez‐Correa Hernando 
Published: May 2021

AbstractThe climatic and geological changes that occurred during the Quaternary, particularly the fluctuations during the glacial and interglacial periods of the Pleistocene, shaped the population demography and geographic distribution of many species. These processes have been studied in several groups of organisms in the Northern Hemisphere, but their influence on the evolution of Neotropical montane species and ecosystems remains unclear. This study contributes to the understanding of the effect of climatic fluctuations during the late Pleistocene on the evolution of Andean mountain forests. First, we describe the nuclear and plastidic DNA patterns of genetic diversity, structure, historical demography, and landscape connectivity of Quercus humboldtii, which is a typical species in northern Andean montane forests. Then, these patterns were compared with the palynological and evolutionary hypotheses postulated for montane forests of the Colombian Andes under climatic fluctuation scenarios during the Quaternary. Our results indicated that populations of Q. humboldtii have high genetic diversity and a lack of genetic structure and that they have experienced a historical increase in connectivity from the last glacial maximum (LGM) to the present. Furthermore, our results showed a dramatic reduction in the effective population size followed by an expansion before the LGM, which is consistent with the results found by palynological studies, suggesting a change in dominance in Andean forests that may be related to ecological factors rather than climate change.