bluuebunny/crossref_metadata_2025_split huggingface dataset:
The genetic deletion of the Dual Specificity Phosphatase 3 (DUSP3) attenuates kidney damage and inflammation following ischaemia/reperfusion injury in mouse
Authors: Khbouz Badr , Rowart Pascal , Poma Laurence , Dahlke Eileen , Bottner Martina , Stokes Matthew , Bolen Géraldine , Rahmouni Souad , Theilig Franziska , Jouret François 
Published: October 2021

AbstractAimDual Specificity Phosphatase 3 (DUSP3) regulates the innate immune response, with a putative role in angiogenesis. Modulating inflammation and perfusion contributes to renal conditioning against ischaemia/reperfusion (I/R). We postulate that the functional loss of DUSP3 is associated with kidney resistance to I/R.MethodsTen C57BL/6 male WT and Dusp3−/− mice underwent right nephrectomy and left renal I/R (30 min/48 hours). Renal injury was assessed based on serum levels of urea (BUN) and Jablonski score. The expression of CD31 and VEGF vascular markers was quantified by RT‐qPCR and immuno‐staining. Renal resistivity index (RRI) was measured in vivo by Doppler ultrasound. Comparative phosphoproteomics was conducted using IMAC enrichment of phosphopeptides. Inflammatory markers were quantified at both mRNA and protein levels in ischaemic vs non‐ischaemic kidneys in WT vs Dusp3−/−.ResultsAt baseline, we located DUSP3 in renal glomeruli and endothelial cells. CD31‐positive vascular network was significantly larger in Dusp3−/− kidneys compared to WT, with a lower RRI in Dusp3−/− mice. Following I/R, BUN and Jablonski score were significantly lower in Dusp3−/− vs WT mice. Phosphoproteomics highlighted a down‐regulation of inflammatory pathways and up‐regulation of phospho‐sites involved in cell metabolism and VEGF‐related angiogenesis in Dusp3−/− vs WT ischaemic kidneys. Dusp3−/− ischaemic kidneys showed decreased mRNA levels of CD11b, TNF‐α, KIM‐1, IL‐6, IL‐1β and caspase‐3 compared to controls. The numbers of PCNA‐, F4‐80‐ and CD11b‐positive cells were reduced in Dusp3−/− vs WT kidneys post‐I/R.ConclusionGenetic inactivation of Dusp3 is associated with kidney conditioning against I/R, possibly due to attenuated inflammation and improved perfusion.
Trends and topics in geographically weighted regression research from 1996 to 2019
Authors: De La Hoz‐M Javier , Fernandez‐Gómez María José , Mendes Susana 
Published: October 2021

AbstractThis research was conducted in order to improve the understanding of the structure, contents, and trend of topics within the existing literature in the field of geographically weighted regression. Additionally, it intended to determine and produce a mapping of scientific networks in the domain of geographically weighted regression. The proposed methodology implements a combination of bibliometric techniques and modelling of topics in order to extract the latent topics from the collected literature by utilising latent Dirichlet allocation and a machine learning tool. The results identified the most prolific authors, the most cited authors, the most representative articles and journals, and the countries which are responsible for the publications.
Food rescue as collective care
Authors: Diprose Gradon , Lee Louise 
Published: October 2021

AbstractRecent research into waste has moved beyond focusing on individual behaviour change to the wider practices, systems, and social norms that construct and perpetuate waste. Running alongside this work on waste, community economy scholars have been exploring how communities form around and care for commons. In this paper we draw on social practice theory and community economy thinking to illustrate how a food rescue organisation, Kaibosh, based in Wellington, New Zealand, has created practices and mobilised meanings that enable people to collectively manage surplus food, address food poverty, and reduce waste. We show how these food rescue and distribution practices push back against individualised despair, moralism, or guilt, and connect people across food systems. Recent critiques of food rescue and wider food philanthropy argue that such practices can be used to justify further welfare retreat, or distract from the need for genuine agri‐food sector reform. While we are sympathetic to these critiques, our findings suggest something different: people get involved in food rescue as a practical way to address food injustice and waste. We show how social practice theory can be used to understand how communities form around a commons that responds to pressing socio‐environmental issues in the here and now.
Real‐world data on NGS using the Oncomine DxTT for detecting genetic alterations in non‐small‐cell lung cancer: WJOG13019L
Authors: Sakata Shinya , Otsubo Kohei , Yoshida Hisako , Ito Kentaro , Nakamura Atsushi , Teraoka Shunsuke , Matsumoto Naohisa , Shiraishi Yoshimasa , Haratani Koji , Tamiya Motohiro , Ikeda Satoshi , Miura Satoru , Tanizaki Junko , Omori Shota , Yoshioka Hiroshige , Hata Akito , Yamamoto Nobuyuki , Nakagawa Kazuhiko 
Published: October 2021

AbstractConsidering the increasing number of identified driver oncogene alterations, additional genetic tests are required to determine the treatment for advanced non‐small‐cell lung cancer (NSCLC). Next‐generation sequencing can detect multiple driver oncogenes simultaneously, enabling the analysis of limited amounts of biopsied tissue samples. In this retrospective, multicenter study (UMIN ID000039523), we evaluated real‐world clinical data using the Oncomine Dx Target Test Multi‐CDx System (Oncomine DxTT) as a companion diagnostic system. Patients with NSCLC who were tested for a panel of 46 genes using the Oncomine DxTT between June 2019 and January 2020 were eligible for enrollment. Patients from 19 institutions affiliated to the West Japan Oncology Group were recruited. The primary endpoint of the study was the success rate of genetic alteration testing in four driver genes (EGFR, ALK, ROS1, and BRAF) using the Oncomine DxTT. In total, 533 patients were enrolled in the study. The success rate of genetic alteration testing for all four genes was 80.1% (95% CI 76.5%‐83.4%). Surgical resection was associated with the highest success rate (88.0%), which was significantly higher than that for bronchoscopic biopsy (76.8%, P = .005). Multivariate analysis revealed a significant difference for surgical resection alone (P = .006, 95% CI 1.36‐6.18, odds ratio 2.90). Although the success rate of genetic alteration testing immediately after Oncomine DxTT induction was not sufficient in this study, optimizing specimen quantity and quality may improve the use of driver gene testing in clinical settings.
Requirements for human cardiomyocytes
Authors: Yu Miao , Lei Wei , Cao Jiani , Wang Lei , Ma Aijin , Zhao Zhen‐Ao , Yang Huang‐Tian , Shen Zhenya , Lan Feng , Cao Feng , Liang Ping , Pei Xuetao , Xiang Andy Peng , Yu Junying , Zhang Yu , Zhang Yong , Li Qiyuan , Zhou Jiaxi , Wei Jun , Peng Yaojin , Zhu Huanxin , Liang Lingmin , Cao Nan , Fu Boqiang , Hao Jie , Zhao Tongbiao , Hu Shijun 
Published: October 2021

Abstract‘Requirements for human cardiomyocytes', jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research, is the first guideline for human cardiomyocytes in China. This standard specifies the technical requirements, test methods, test regulations, instructions for use, labelling requirements, packing requirements, storage requirements, transportation requirements and waste disposal requirements for human cardiomyocytes, which is designed to normalize and standardize human cardiomyocyte research and production. It was originally released by the China Society for Cell Biology on 9 January 2021. We hope that the publication of this guideline will promote institutional establishment, acceptance and execution of proper protocols, and accelerate the international standardization of human cardiomyocytes for applications.
Clinical and EEG factors associated with antiseizure medication resistance in idiopathic generalized epilepsy
Authors: Kamitaki Brad K. , Janmohamed Mubeen , Kandula Padmaja , Elder Christopher , Mani Ram , Wong Stephen , Perucca Piero , O’Brien Terence J. , Lin Haiqun , Heiman Gary A. , Choi Hyunmi 
Published: October 2021

AbstractObjectiveWe sought to determine which combination of clinical and electroencephalography (EEG) characteristics differentiate between an antiseizure medication (ASM)–resistant vs ASM‐responsive outcome for patients with idiopathic generalized epilepsy (IGE).MethodsThis was a case‐control study of ASM‐resistant cases and ASM‐responsive controls with IGE treated at five epilepsy centers in the United States and Australia between 2002 and 2018. We recorded clinical characteristics and findings from the first available EEG study for each patient. We then compared characteristics of cases vs controls using multivariable logistic regression to develop a predictive model of ASM‐resistant IGE.ResultsWe identified 118 ASM‐resistant cases and 114 ASM‐responsive controls with IGE. First, we confirmed our recent finding that catamenial epilepsy is associated with ASM‐resistant IGE (odds ratio [OR] 3.53, 95% confidence interval [CI] 1.32–10.41, for all study subjects) after covariate adjustment. Other independent factors seen with ASM resistance include certain seizure‐type combinations (absence, myoclonic, and generalized tonic‐clonic seizures [OR 7.06, 95% CI 2.55–20.96]; absence and generalized tonic‐clonic seizures [OR 4.45, 95% CI 1.84–11.34]), as well as EEG markers of increased generalized spike‐wave discharges (GSWs) in sleep (OR 3.43, 95% CI 1.12–11.36 for frequent and OR 7.21, 95% CI 1.50–54.07 for abundant discharges in sleep) and the presence of generalized polyspike trains (GPTs; OR 5.49, 95% CI 1.27–38.69). The discriminative ability of our final multivariable model, as measured by area under the receiver‐operating characteristic curve, was 0.80.SignificanceMultiple clinical and EEG characteristics independently predict ASM resistance in IGE. To improve understanding of a patient's prognosis, clinicians could consider asking about specific seizure‐type combinations and track whether they experience catamenial epilepsy. Obtaining prolonged EEG studies to record the burden of GSWs in sleep and assessing for the presence of GPTs may provide additional predictive value.
Shifting stoichiometry: Long‐term trends in stream‐dissolved organic matter reveal altered C:N ratios due to history of atmospheric acid deposition
Authors: Rodríguez‐Cardona Bianca M. , Wymore Adam S. , Argerich Alba , Barnes Rebecca T. , Bernal Susana , Brookshire E. N. Jack , Coble Ashley A. , Dodds Walter K. , Fazekas Hannah M. , Helton Ashley M. , Johnes Penny J. , Johnson Sherri L. , Jones Jeremy B. , Kaushal Sujay S. , Kortelainen Pirkko , López‐Lloreda Carla , Spencer Robert G. M. , McDowell William H. 
Published: October 2021

AbstractDissolved organic carbon (DOC) and nitrogen (DON) are important energy and nutrient sources for aquatic ecosystems. In many northern temperate, freshwater systems DOC has increased in the past 50 years. Less is known about how changes in DOC may vary across latitudes, and whether changes in DON track those of DOC. Here, we present long‐term DOC and DON data from 74 streams distributed across seven sites in biomes ranging from the tropics to northern boreal forests with varying histories of atmospheric acid deposition. For each stream, we examined the temporal trends of DOC and DON concentrations and DOC:DON molar ratios. While some sites displayed consistent positive or negative trends in stream DOC and DON concentrations, changes in direction or magnitude were inconsistent at regional or local scales. DON trends did not always track those of DOC, though DOC:DON ratios increased over time for ~30% of streams. Our results indicate that the dissolved organic matter (DOM) pool is experiencing fundamental changes due to the recovery from atmospheric acid deposition. Changes in DOC:DON stoichiometry point to a shifting energy‐nutrient balance in many aquatic ecosystems. Sustained changes in the character of DOM can have major implications for stream metabolism, biogeochemical processes, food webs, and drinking water quality (including disinfection by‐products). Understanding regional and global variation in DOC and DON concentrations is important for developing realistic models and watershed management protocols to effectively target mitigation efforts aimed at bringing DOM flux and nutrient enrichment under control.
Impact of smoking on the eradication of Helicobacter pylori
Authors: Yu Jing , Yang Peng , Qin Xiangrong , Li Chunjian , Lv Yiming , Wang Xiaoyong 
Published: October 2021

AbstractBackground and AimAlthough the association between the eradication of Helicobacter pylori (H. pylori) and smoking has been confirmed through a meta‐analysis, many new studies have reported inconsistent conclusions. An up‐to‐date meta‐analysis based on published relevant studies was conducted in this study to address this issue.MethodsEligible studies up to January 2021 were screened and retrieved using PubMed and Web of Science as well as by performing a manual review of references. We calculated the pooled odd ratios (OR) with the 95% confidence interval (CI). Subgroup and sensitivity analyses were also performed. Begg's test was used to determine the publication bias.ResultsIn total, 39 studies were included in the meta‐analysis. The results showed that smoking increases the failure rate of H. pylori eradication treatment (OR = 1.70, 95%CI, 1.49–1.93). The risk of failure also increases with an increase in the smoking dose (>5 cigarettes per day) (OR = 2.59, 95%CI, 1.28–5.24) and the current smoking status (continued to smoke during treatment) (OR = 2.49, 95%CI, 1.52–4.06). Studies with a large proportion of patients with peptic ulcer (OR = 2.14, 95%CI, 1.51–3.02) revealed a higher failure rate among smokers than those with a low proportion of patients with peptic ulcer (OR = 1.57, 95%CI, 1.36–1.81). When vonoprazan (VPZ) was used to treat H. pylori infection, smoking did not affect the eradication rate (OR = 0.94, 95%CI, 0.51–1.75).ConclusionSmoking increases the failure rate of H. pylori eradication treatment. The risk of H. pylori eradication failure in smokers increases with a current smoking status and a high smoking dose. However, when VPZ is used to treat the H. pylori infection, smoking has no effect on the eradication rate.
Industrie 4.0 ou réseaux de production? Plusieurs voies pour la transformation numérique de l'industrie manufacturière et du travail
Authors: BUTOLLO Florian , SCHNEIDEMESSER Lea 
Published: October 2021

RésuméDans cette analyse théorique et empirique sur les différentes options en vue d'une transformation numérique de l'industrie manufacturière, les auteurs reprennent des idées de Piore et Sabel (1989) pour dénoncer les partis pris du concept d'industrie 4.0, lui opposant le modèle du réseau de production, dans lequel la flexibilité dépend non pas de techniques de production sophistiquées, mais de la réorganisation des interactions clients‐fournisseurs au moyen de plateformes numériques. Avec quels effets pour le travail? Une montée en gamme, si on évolue vers un travail plus qualifié, de type artisanal, mais un nivellement par le bas dans les secteurs très sensibles au prix.
The impact of receptor of advanced glycation end‐products polymorphisms on prostate cancer progression and clinicopathological characteristics
Authors: Chou Ying‐Erh , Hsieh Ming‐Ju , Wang Shian‐Shiang , Lin Chia‐Yen , Chen Yen‐Yu , Ho Yung‐Chuan , Yang Shun‐Fa 
Published: October 2021

AbstractThe receptor for advanced glycation end products (RAGE) overexpression was suggested to be associated with prostate cancer development and poor prognosis. In this study, we focused on the correlations between the clinicopathological characteristics and susceptibility of prostate cancer and RAGE single‐nucleotide polymorphisms (SNPs). In 579 prostate cancer patients, the RAGE SNPs rs1800625, rs1800624, rs2070600 and rs184003 in patients with or without grade group upgrade were analysed with real‐time polymerase chain reaction. The results demonstrated that the prostate cancer patients who carried the RAGE SNPs rs2070600 ‘GA’ genotypic variants were significantly associated with lower risk to develop grade group upgrade. Moreover, patients with the RAGE rs1800625 ‘TC + CC’ genotypic variants were associated with higher risk of perineural invasion. In 343 prostate cancer patients who carried the RAGE rs1800625 ‘TC + CC’ genotype without grade group upgrade were correlated with higher risk of biochemical recurrence and perineural invasion. In the analysis of TCGA database, significant differences of the RAGE mRNA level were found between the normal controls and prostate cancer patients (p < 0.0001), and the pathologic stage N1 and N0 patients (p = 0.0027). The prostate cancer patients with high RAGE expression were associated with lower overall survival rate (p = 0.025). In conclusion, our results have revealed that the RAGE SNPs rs2070600 and rs1800625 were associated with the grade group upgrade of prostate cancer and clinical status. The RAGE polymorphisms may provide as a pivotal predictor to evaluate prostate cancer disease progression and prognosis.
Evaluation of hair and nail cortisol concentrations and associations with behavioral, physical, and environmental indicators of chronic stress in cats
Authors: Contreras Elena T. , Vanderstichel Raphael , Hovenga Claire , Lappin Michael R. 
Published: October 2021

AbstractBackgroundChronic stress is implicated in behavioral and health issues in cats, but methods for recognition, evaluation, and measurement of stress are lacking. Cortisol concentration is typically used as an indicator of stress.ObjectivesTo evaluate use of an enzyme immunoassay to quantitate hair and nail cortisol concentrations (HCC and NCC) in cats and evaluate associations between HCC and NCC and behavioral, physical, and environmental correlates of chronic stress in cats.AnimalsForty‐eight adult, owned or community cats.MethodsCross‐sectional study. Nail clippings and hair were collected from cats. Medical history and cat daily lifestyle questionnaires were completed by owners or caretakers. A commercial laboratory performed cortisol extraction and quantification using a validated enzyme immunoassay kit. Correlational and regression analyses were used to evaluate associations between HCC and NCC and behavioral, environmental, and medical factors.ResultsHair and nail cortisol concentrations were significantly associated (rs = 0.70; P < .001), but HCCs varied widely within and among cats. Cats with litterbox issues had significantly increased HCC (P = .02) and NCC (P = .001) as compared to cats without litterbox issues. Cats with groomed coats had lower HCCs (P = .02) as compared to cats without groomed coats, whereas cats with dander and mats had higher NCCs (P = .01) as compared to cats without dander and mats.Conclusions and Clinical ImportanceThe quantification of NCCs might improve identification and evaluation of chronic stress in cats. The variability of HCCs in individual cats warrants caution using this measurement in chronic stress studies.
Questions on Public Policy and Trust during Covid‐19 in the Middle East and North Africa
Authors: Yellinek Roie 
Published: October 2021

AbstractTrust is a recurring theme in social‐science literature for disciplines as diverse as psychology, political science, anthropology, sociology, and management. Recently, the concept has even been studied in neurobiology, behavioral economics, and computer science. In discussing the impact of state responses to Covid‐19 on trust in government, one should distinguish between two types of trust: political and social. Political trust refers to the extent to which people have trust in institutions; social trust refers to trust in other people within the community and beyond. While some studies suggest that political and social trust tend to correlate with each other, most studies examine these concepts separately. This article focuses on the impact of Covid‐19 on trust in government in the Middle East: political trust in the context of the pandemic.
Norms of criminal conviction
Authors: Lackey Jennifer 
Published: October 2021

AbstractIn this paper, I offer three different arguments against the view that knowledge is the epistemic norm governing criminal convictions in the Anglo‐American system. The first two show that neither the truth of a juror's verdict nor the juror's belief in the defendant's guilt is necessary for voting to convict in an epistemically permissible way. Both arguments challenge the necessity dimension of the knowledge norm. I then show—by drawing on evidence that is admissible through exclusionary rules—that knowledge is also not sufficient for epistemically proper conviction. A central thesis operative in all of these arguments is that the sort of ideal epistemology underwriting the knowledge norm of conviction should be rejected and replaced with a non‐ideal approach. I then defend an alternative, justificationist norm of criminal conviction that not only avoids the problems afflicting the knowledge account, but also takes seriously the important role that narratives play in criminal courts.
Quantifying skin sensitivity caused by mechanical insults: A review
Authors: Chaturvedi Pakhi , Worsley Peter R. , Zanelli Giulia , Kroon Wilco , Bader Dan L. 
Published: October 2021

AbstractBackgroundSkin sensitivity (SS) is a commonly occurring response to a range of stimuli, including environmental conditions (e.g., sun exposure), chemical irritants (e.g., soaps and cosmetics), and mechanical forces (e.g., while shaving). From both industry and academia, many efforts have been taken to quantify the characteristics of SS in a standardised manner, but the study is hindered by the lack of an objective definition.MethodsA review of the scientific literature regarding different parameters attributed to the loss of skin integrity and linked with exhibition of SS was conducted. Articles included were screened for mechanical stimulation of the skin, with objective quantification of tissue responses using biophysical or imaging techniques. Additionally, studies where cohorts of SS and non‐SS individuals were reported have been critiqued.ResultsThe findings identified that the structure and function of the stratum corneum and its effective barrier properties are closely associated with SS. Thus, an array of skin tissue responses has been selected for characterization of SS due to mechanical stimuli, including: transepidermal water loss, hydration, redness, temperature, and sebum index. Additionally, certain imaging tools allow quantification of the superficial skin layers, providing structural characteristics underlying SS.ConclusionThis review proposes a multimodal approach for identification of SS, providing a means to characterise skin tissue responses objectively. Optical coherence tomography (OCT) has been suggested as a suitable tool for dermatological research with clinical applications. Such an approach would enhance the knowledge underlying the multifactorial nature of SS and aid the development of personalised solutions in medical and consumer devices.