bluuebunny/crossref_metadata_2025_split huggingface dataset:
Size matters in atrial fibrillation: the underestimated importance of reduction of contiguous electrical mass underlying the effectiveness of catheter ablation
Authors: Hartley Adam , Shalhoub Joseph , Ng Fu Siong , Krahn Andrew D , Laksman Zachary , Andrade Jason G , Deyell Marc W , Kanagaratnam Prapa , Sikkel Markus B 
Published: March 2021

Abstract
Evidence has accumulated over the last century of the importance of a critical electrical mass in sustaining atrial fibrillation (AF). AF ablation certainly reduces electrically contiguous atrial mass, but this is not widely accepted to be an important part of its mechanism of action. In this article, we review data showing that atrial size is correlated in many settings with AF propensity. Larger mammals are more likely to exhibit AF. This is seen both in the natural world and in animal models, where it is much easier to create a goat model than a mouse model of AF, for example. This also extends to humans—athletes, taller people, and obese individuals all have large atria and are more likely to exhibit AF. Within an individual, risk factors such as hypertension, valvular disease and ischaemia can enlarge the atrium and increase the risk of AF. With respect to AF ablation, we explore how variations in ablation strategy and the relative effectiveness of these strategies may suggest that a reduction in electrical atrial mass is an important mechanism of action. We counter this with examples in which there is no doubt that mass reduction is less important than competing theories such as ganglionated plexus ablation. We conclude that, when considering future strategies for the ablative therapy of AF, it is important not to discount the possibility that contiguous electrical mass reduction is the most important mechanism despite the disappointing consequence being that enhancing success rates in AF ablation may involve greater tissue destruction.
Optimal breeding-value prediction using a sparse selection index
Authors: Lopez-Cruz Marco , de los Campos Gustavo 
Published: March 2021

Abstract
Genomic prediction uses DNA sequences and phenotypes to predict genetic values. In homogeneous populations, theory indicates that the accuracy of genomic prediction increases with sample size. However, differences in allele frequencies and linkage disequilibrium patterns can lead to heterogeneity in SNP effects. In this context, calibrating genomic predictions using a large, potentially heterogeneous, training data set may not lead to optimal prediction accuracy. Some studies tried to address this sample size/homogeneity trade-off using training set optimization algorithms; however, this approach assumes that a single training data set is optimum for all individuals in the prediction set. Here, we propose an approach that identifies, for each individual in the prediction set, a subset from the training data (i.e., a set of support points) from which predictions are derived. The methodology that we propose is a sparse selection index (SSI) that integrates selection index methodology with sparsity-inducing techniques commonly used for high-dimensional regression. The sparsity of the resulting index is controlled by a regularization parameter (λ); the G-Best Linear Unbiased Predictor (G-BLUP) (the prediction method most commonly used in plant and animal breeding) appears as a special case which happens when λ = 0. In this study, we present the methodology and demonstrate (using two wheat data sets with phenotypes collected in 10 different environments) that the SSI can achieve significant (anywhere between 5 and 10%) gains in prediction accuracy relative to the G-BLUP.
Gender, Recruitment and Medicine at Ravensbrück Concentration Camp, 1939–1942
Authors: Docking Kate 
Published: March 2021

Abstract
This article sheds light on how gender intersected with the recruitment of three female doctors to Ravensbrück, a concentration camp in the Third Reich designated to intern only women prisoners. The favourable pay on offer, the prospect of permanent positions and their pre-existing affiliation with Nazi organizations led the female doctors to take jobs at the camp. While these women were hired to work at Ravensbrück as a result of the contemporary belief that women physicians were better suited to treating female patients than were male doctors, this gendered medical ideal was increasingly usurped in the camp hospital. Herta Oberheuser, one of the doctors, performed cruel experiments on female prisoners with venereal diseases and conducted humiliating gynaecological examinations on women arriving at the camp. Ultimately, we cannot fully understand the descent into medical malpractice in the hospital—including the types of medical atrocities enacted, who was subjected to them and who perpetrated them—without a detailed gendered analysis that incorporates the female doctors. In demonstrating how contemporary gendered medical ideals were actively violated, this article also asks how significant gender was in a women’s concentration camp.
Strengthening data collection and use for quality improvement in primary care: the case of Costa Rica
Authors: Pesec Madeline , Spigel Lauren , Granados José María Molina , Bitton Asaf , Hirschhorn Lisa R , Brizuela Jorge Arturo Jiménez , Pignone Michael , Sáenz María del Rocío , Schwarz Dan , Villegas del Carpio Oscar , Wilson Ira B , Zamora Méndez Eduardo , Ratcliffe Hannah L 
Published: March 2021

Abstract
Costa Rica is a bright spot of primary healthcare (PHC) performance, providing first-contact accessibility and continuous, comprehensive, coordinated, and patient-centered care to its citizens. Previous research hypothesized that strong data collection and use for quality improvement are central to Costa Rica’s success. Using qualitative data from 40 interviews with stakeholders across the Costa Rican healthcare system, this paper maps the various data streams at the PHC level and delineates how these data are used to make decisions around insuring and improving the quality of PHC delivery. We describe four main types of PHC data: individual patient data, population health data, national healthcare delivery data, and local supplementary healthcare delivery data. In particular, we find that the Healthcare Delivery Performance Index—a ranking of the nation’s 106 Health Areas using 15 quality indicators—is utilized by Health Area Directors to create quality improvement initiatives, ranging from education and coaching to optimization of care delivery and coordination. By ranking Health Areas, the Index harnesses providers’ intrinsic motivation to stimulate improvement without financial incentives. We detail how a strong culture of valuing data as a tool for improving population health and robust training for personnel have enabled effective data collection and use. However, we also find that the country’s complex data systems create unnecessary duplication and can inhibit efficient data use. Costa Rica’s experience with data collection, analysis, and use for quality improvement hold important lessons for PHC in other public sector systems.
The Use of Arthropod-Borne Challenge Models in BSL-3Ag and BSL-4 Biocontainment
Authors: Higgs Stephen , Vanlandingham Dana L , Huang Yan-Jang S , Thangamani Saravanan 
Published: March 2021

Abstract
The study of many arthropod-borne pathogens requires high biosafety considerations, including the use of specialized facilities and equipment for arthropod containment. Mosquito- and tick-borne viruses such as yellow fever, West Nile, and Crimean Congo hemorrhagic fever viruses require facilities that are suitable for housing vertebrates. Multidisciplinary studies that incorporate the vector, vertebrate, and pathogens are essential for a complete understanding of the interactions between these transmission cycle components, especially if they aim to evaluate and model relative susceptibilities of different arthropods and vertebrates to infection and transmission between these. Under laboratory conditions, these studies can be relatively simple, for example, involving colonized arthropods, small animals, and attenuated viruses. Other studies are complex with large animals, high-biocontainment pathogens, and field-collected arthropods. These require a higher level of containment and special design considerations. Both of these types of experiments have their relative merits. A thorough understanding of the issues related to these types of studies and the benefits and drawbacks to using various challenge models will enable the researcher to develop realistic goals for various experiments. This review examines the varied issues that should be considered prior to starting these experiments and covers the basics from the procurement of various arthropods, rearing, high-containment facilities and operational issues specific to work with arthropods, types of infection experiments, and specific issues with arthropod and animal experiments in biosafety levels 3 and 4.
Midwives and Humanitarian Bureaucracy: Managing Migration at a Postcolonial Border
Authors: Sahraoui Nina 
Published: March 2021

AbstractDrawing on Foucauldian biopolitics, Max Weber's and Hannah Arendt's understandings of bureaucracy, and Achille Mbembe's theoretical insights into necropolitical power, I propose the notion of humanitarian bureaucracy to account for the involvement of medical personnel in the summary deportations of pregnant Comorian women in Mayotte, a French overseas department in the Indian Ocean. In addition to their usual consultations, hospital midwives are asked to assess the health of pregnant women arrested at sea in order to state whether they can be lawfully detained, while deportations happen within hours owing to the specificities of this postcolonial migration regime. The notion of humanitarian bureaucracy traces how a series of bureaucratic acts, duly sanctioned by qualified professionals, performs a minimal and fragmented biopolitical surveillance that neutralizes the question of responsibility and rejects the racialized Other into a liminal space between failing to “make live” and avoiding to “let die.” The article argues that humanitarian bureaucracy represents an ambivalent power, stemming from biopolitics yet producing necropolitics through processes of racialization. The article draws on three months of fieldwork conducted in Mayotte in 2017 and analyzes midwives’ discourses and bureaucratic practices as materialized by the medical certificates they deliver in the context of these assessments.
Emergence of Delta-8 Tetrahydrocannabinol in DUID Investigation Casework: Method Development, Validation and Application
Authors: Chan-Hosokawa Ayako , Nguyen Loan , Lattanzio Nicole , Adams Wendy R 
Published: March 2021

Abstract
Cannabinoid is the most frequently reported illicit drug class in Driving Under the Influence of Drugs (DUID) investigation casework. In recent years, our laboratory observed an increasing rate of overlapping peaks for the cannabinoid confirmation performed using 2D high-performance liquid chromatography (LC)--tandem mass spectrometry (MS-MS). Starting in early 2018, the incidence of unresolved interfering substances increased, contributing to a higher rate of canceled testing that peaked at 3.7% in February 2019. The observed interference demonstrates a distinctive pattern affecting the identification and quantification of both delta-9 tetrahydrocannabinol (THC) and delta-9 carboxy THC. An improved quantitative method was developed and validated to separate delta-8 and -9 isomers and their metabolites in blood. All acceptance criteria were met, with identical measurement ranges from the original method (lower limit of quantitation: 0.5 ng/mL for delta-9 THC, 1.0 ng/mL for 11-hydroxy delta-9 THC and 5.0 ng/mL for delta-9 carboxy THC). Cannabinoids were extracted from whole blood using liquid–liquid extraction, separated in a 2D LC system over a run time of 10 min and detected by an MS-MS system equipped with ESI source operating in positive ionization mode with scheduled multiple reaction mass spectrometric monitoring. The LC system consisted of a pair of Phenomenex® SecurityGuard™ C6 Phenyl (4 × 2 mm) cartridges for extracting the compounds with 5 mM ammonium formate buffer in deionized (DI) water and 0.1% formic acid in methanol as mobile phase, and a Phenomenex® Kinetex C18 column (100 × 3 mm) with 0.1% formic acid in DI water and 0.1% formic acid in methanol for LC separation at 45°C. Each set of isomers was fully resolved by the longer run-time method. To the authors’ knowledge, this is the first report of a method that successfully quantitates these primary cannabinoids in blood specimens where significant concentrations of both delta-9 and delta-8 isomers are present.
Evidence Gaps in Cancer Survivorship Care: A Report From the 2019 National Cancer Institute Cancer Survivorship Workshop
Authors: Gallicchio Lisa , Tonorezos Emily , de Moor Janet S , Elena Joanne , Farrell Margaret , Green Paige , Mitchell Sandra A , Mollica Michelle A , Perna Frank , Saiontz Nicole Gottlieb , Zhu Li , Rowland Julia , Mayer Deborah K 
Published: March 2021

AbstractToday, there are more than 16.9 million cancer survivors in the United States; this number is projected to grow to 22.2 million by 2030. Although much progress has been made in describing cancer survivors’ needs and in improving survivorship care since the seminal 2006 Institute of Medicine report “From Cancer Patient to Cancer Survivor: Lost in Transition,” there is a need to identify evidence gaps and research priorities pertaining to cancer survivorship. Thus, in April 2019, the National Cancer Institute convened grant-funded extramural cancer survivorship researchers, representatives of professional organizations, cancer survivors, and advocates for a 1-day in-person meeting. At this meeting, and in a subsequent webinar aimed at soliciting input from the wider survivorship community, evidence gaps and ideas for next steps in the following 6 areas, identified from the 2006 Institute of Medicine report, were discussed: surveillance for recurrence and new cancers, management of long-term and late physical effects, management of long-term and late psychosocial effects, health promotion, care coordination, and financial hardship. Identified evidence gaps and next steps across the areas included the need to understand and address disparities among cancer survivors, to conduct longitudinal studies as well as longer-term (&gt;5 years postdiagnosis) follow-up studies, to leverage existing data, and to incorporate implementation science strategies to translate findings into practice. Designing studies to address these broad evidence gaps, as well as those identified in each area, will expand our understanding of cancer survivors’ diverse needs, ultimately leading to the development and delivery of more comprehensive evidence-based quality care.
Neural Responses to Social Reward Predict Depressive Symptoms in Adolescent Girls During the COVID-19 Pandemic
Authors: Sequeira Stefanie L , Silk Jennifer S , Hutchinson Emily , Jones Neil P , Ladouceur Cecile D 
Published: March 2021

AbstractObjectiveAdolescent depression is increasing during the COVID-19 pandemic, possibly related to dramatic social changes. Individual-level factors that contribute to social functioning, such as temperament and neural reactivity to social feedback, may confer risk for or resilience against depressive symptoms during the pandemic.MethodsNinety-three girls (12–17 years) oversampled for high shy/fearful temperament were recruited from a longitudinal study for a follow-up COVID-19 study. During the parent study (2016–2018), participants completed a functional magnetic resonance imaging task eliciting neural activity to performance-related social feedback. Depressive symptoms were assessed during the parent study and COVID-19 follow-up (April–May 2020). In 65 participants with complete data, we examined how interactions between temperament and neural activation to social reward or punishment in a socio-affective brain network predict depressive symptoms during COVID-19.ResultsDepressive symptoms increased during COVID-19. Significant interactions between temperament and caudate, putamen, and insula activation to social reward were found. Girls high in shy/fearful temperament showed negative associations between neural activation to social reward and COVID-19 depressive symptoms, whereas girls lower in shy/fearful temperament showed positive associations.ConclusionsGirls high in shy/fearful temperament with reduced neural activation to social reward may be less likely to engage socially, which could be detrimental during the pandemic when social interactions are limited. In contrast, girls lower in shy/fearful temperament with heightened neural reactivity to social reward may be highly motivated to engage socially, which could also be detrimental with limited social opportunities. In both cases, improving social connection during the pandemic may attenuate or prevent depressive symptoms.
Trends of the global, regional and national incidence of malaria in 204 countries from 1990 to 2019 and implications for malaria prevention
Authors: Liu Qiao , Jing Wenzhan , Kang Liangyu , Liu Jue , Liu Min 
Published: March 2021

Abstract

Background
Malaria is a life-threatening disease worldwide, but lacks studies on its incidence at the global level. We aimed to describe global trends and regional diversities in incidence of malaria infection, to make global tailored implications for malaria prevention.

Methods
We used the data from the Global Burden of Disease Study 2019. The age-standardized incidence rate (ASR) and absolute number of malaria episodes showed the epidemic status of malaria infection. The estimated annual percentage change of ASR and changes in malaria episodes quantified the malaria incidence trends. The connection between ASRs and traveller number indicated infection risk for travellers.

Results
Globally, the malaria ASR decreased by an average 0.80% (95% confidence interval 0.58–1.02%) per year from 1990 to 2019; however, it slightly increased from 3195.32 per 100 000 in 2015 to 3247.02 per 100 000 in 2019. The incidence rate of children under 5 was higher than other age groups. A total of 40 countries had higher ASRs in 2019 than in 2015, with the largest expansion in Cabo Verde (from 2.02 per 100 000 to 597.00 per 100 000). After 2015, the ASRs in high-middle, middle and low-middle Socio-demographic Index regions began to rise and the uptrends remained in 2019. Central, Western and Eastern Sub-Saharan Africa had the highest ASRs since 1990, and traveller number in Eastern and Western Sub-Saharan Africa increased by 31.24 and 7.58%, respectively, from 2017 to 2018. Especially, most countries with ASR over 10 000 per 100 000 had increase in traveller number from 2017 to 2018, with the highest change by 89.56% in Mozambique.

Conclusions
Malaria is still a public health threat for locals and travellers in Sub-Saharan Africa and other malaria-endemic areas, especially for children under 5. There were unexpected global uptrends of malaria ASRs from 2015 to 2019. More studies are needed to achieve the goal of malaria elimination.
NGC 6611 601: a hot pre-main-sequence spectroscopic binary containing a centrifugal magnetosphere host star
Authors: Shultz M E , Alecian E , Petit V , Bagnulo S , Böhm T , Folsom C P , Wade G A ,   the MiMeS Collaboration
Published: March 2021

ABSTRACT
W 601 (NGC 6611 601) is one of the handful of known magnetic Herbig Ae/Be stars. We report the analysis of a large data set of high-resolution spectropolarimetry. The star is a previously unreported spectroscopic binary, consisting of two B2 stars with a mass ratio of 1.8, masses of 12 and 6.2 M⊙, in an eccentric 110-d orbit. The magnetic field belongs to the secondary, W 601 B. The H α emission is consistent with an origin in W 601 B’s centrifugal magnetosphere; the star is therefore not a classical Herbig Be star in the sense that its emission is not formed in an accretion disc. However, the low value of log g = 3.8 determined via spectroscopic analysis and the star’s membership in the young NGC 6611 cluster are most consistent with it being on the pre-main sequence. The rotational period inferred from the variability of the H α line and the longitudinal magnetic field 〈Bz〉 is 1.13 d. Modelling of Stokes V and 〈Bz〉 indicates a surface dipolar magnetic field Bd between 6 and 11 kG. With its strong emission, rapid rotation, and strong surface magnetic field, W 601 B is likely a precursor to H α-bright magnetic B-type stars such as σ Ori E. By contrast, the primary is an apparently non-magnetic (Bd &lt; 300 G) pre-main-sequence early B-type star. In accordance with expectations from magnetic braking, the non-magnetic primary is apparently more rapidly rotating than the magnetic star.
QPOs and Orbital elements of X-ray binary 4U 0115+63 during the 2017 outburst observed by Insight-HXMT
Authors: Ding Y Z , Wang W , Zhang P , Bu Q C , Cai C , Cao X L , Zhi C , Chen L , Chen T X , Chen Y B , Chen Y , Chen Y P , Cui W W , Du Y Y , Gao G H , Gao H , Ge M Y , Gu Y D , Guan J , Guo C C , Han D W , Huang Y , Huo J , Jia S M , Jiang W C , Jin J , Kong L D , Li B , Li C K , Li G , Li T P , Li W , Li X , Li X B , Li X F , Li Z W , Liang X H , Liao J Y , Liu B S , Liu C Z , Liu H X , Liu H W , Liu X J , Lu F J , Lu X F , L Q , T L , Ma R C , Ma X , Meng B , Nang Y , Nie J Y , Qu J L , Ren X Q , Sai N , Song L M , Song X Y , Sun L , Tan Y , Tao L , Tuo Y L , Wang L J , Wang P J , Wang W S , Wang Y S , Wen X Y , Wu B Y , Wu B B , Wu M , Xiao G C , Xiao S , Xiong S L , Xu Y P , Yang R J , Yang S , Yang Y J , Yi Q B , Yin Q Q , You Y , Zhang F , Zhang H M , Zhang J , Zhang P , Zhang S , Zhang S N , Zhang W C , Zhang W , Zhang Y F , Zhang Y H , Zhao H S , Zhao X F , Zheng S J , Zheng Y G , Zhou D K 
Published: March 2021

Abstract
In this paper, we presented a detailed timing analysis of a prominent outburst of 4U 0115+63 detected by Insight-HXMT in 2017 August. The spin period of the neutron star was determined to be 3.61398 ± 0.00002 s at MJD 57978. We measured the period variability and extract the orbital elements of the binary system. The angle of periastron evolved with a rate of $0.048^\circ \pm 0.003^\circ \rm \, yr^{-1}$. The light curves are folded to sketch the pulse profiles in different energy ranges. A multi-peak structure in 1-10 keV is clearly illustrated. We introduced wavelet analysis into our data analysis procedures to study QPO signals and perform a detailed wavelet analysis in many different energy ranges. Through the wavelet spectra, we report the discovery of a QPO at the frequency ∼10 mHz. In addition, the X-ray light curves showed multiple QPOs in the period of ∼16 − 32 s and ∼67 − 200 s. We found that the ∼100 s QPO was significant in most of the observations and energies. There exist positive relations between X-ray luminosity and their Q-factors and S-factors, while the QPO periods have no correlation with X-ray luminosity. In wavelet phase maps, we found that the pulse phase of ∼67 − 200 s QPO drifting frequently while the ∼16 − 32 s QPO scarcely drifting. The dissipation of oscillations from high energy to low energy was also observed. These features of QPOs in 4U 0115+63 provide new challenge to our understanding of their physical origins.