bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune response to COVID-19 vaccination is attenuated by poor disease control and antimyeloma therapy with vaccine driven divergent T cell response
Authors: Ramasamy Karthik , Sadler Ross , Jeans Sally , Weeden Paul , Varghese Sherin , Turner Alison , Larham Jemma , Gray Nathanael , Carty Oluremi , Barrett Joe , Bowcock Stella , Oppermann Udo , Cook Gordon , Kyriakou Chara , Drayson Mark , Basu Supratik , Moore Sally , McDonald Sarah , Gooding Sarah , Javaid Muhammad K 
Published: October 2021

SummaryBackgroundMyeloma patients frequently respond poorly to bacterial and viral vaccination. A few studies have reported poor humoral immune responses in myeloma patients to COVID-19 vaccination.MethodsUsing a prospective study of myeloma patients in UK Rudy Study cohort, we assessed humoral and Interferon gamma release assay (IGRA) cellular immune responses to COVID-19 vaccination post second COVID-19 vaccine administration.FindingsWe report data from 214 adults with myeloma (n=204) or smouldering myeloma (n=10) who provided blood samples at least 3 weeks after second vaccine dose. Positive Anti-Spike antibody levels (> 50 IU/ml) were detected in 189/203 (92.7%), positive IGRA responses were seen in 97/158 (61.4%) myeloma patients. Only 10/158 (6.3%) patients were identified to have both a negative IGRA and negative Anti-Spike protein antibody response. 95/158 (60.1%) patients produced positive results for both anti-Spike protein serology and IGRA. After adjusting for disease severity and myeloma therapy, poor humoral immune response was predicted by male gender. Predictors of poor IGRA included anti-CD38/ anti-BCMA therapy and Pfizer-BioNTech (PB) vaccination.InterpretationSignificant majority of myeloma patients elicit Anti-Spike protein antibody responses to COVID-19 vaccine with 60% of myeloma patients showing both humoral and T cell response. Predictors of a poor immune response included male gender, myeloma therapy regimen and administration of Pfizer-BioNTech vaccination. Further work is required to understand the clinical significance of divergent cellular response to vaccination.FundingFunding for this study has been received from Blood Cancer Vaccine Consortium and Janssen UK. RUDY platform has been funded by NIHR.
How different pre-existing mental disorders and their co-occurrence affects clinical outcomes of COVID-19? A study based on real-world data in the Southern United States
Authors: Qiao Shan , Zhang Jiajia , Chen Shujie , Olatosi Bankole , Hardeman Suzanne , Narasimhan Meera , Bruner Larisa , Diedhiou Abdoulaye , Scott Cheryl , Mansaray Ali , Weissman Sharon , Li Xiaoming 
Published: October 2021

AbstractImportanceA growing body of research focuses on the impact of pre-existing mental disorders on clinical outcomes of COVID-19 illness. Although a psychiatric history might be an independent risk factor for COVID-19 infection and mortality, no studies have systematically investigated how different clusters of pre-existing mental disorders may affect COVID-19 clinical outcomes or showed how the coexistence of mental disorder clusters is related to COVID-19 clinical outcomes.ObjectiveTo explore how different pre-existing mental disorders and their co-occurrence affects COVID-19-related clinical outcomes based on real-world data.Design, Setting, and ParticipantsUsing a retrospective cohort study design, a total of 476,775 adult patients with lab-confirmed and probable COVID-19 between March 06, 2020 and April 14, 2021 in South Carolina, United States were included in the current study. The electronic health record data of COVID-19 patients were linked to all payer-based claims data through the SC Revenue and Fiscal Affairs Office.Main Outcomes and MeasuresKey COVID-19 clinical outcomes included severity, hospitalization, and death. COVID-19 severity was defined as asymptomatic, mild, and moderate/severe. Pre-existing mental disorder diagnoses from Jan 2, 2019 to Jan 14, 2021 were extracted from the patients’ healthcare utilization data via ICD-10 codes. Mental disorders were categorized into internalizing disorders, externalizing disorders, and thought disorders.ResultsOf the 476,775 COVID-19 patients, 55,300 had pre-existing mental disorders. There is an elevated risk of COVID-19-related hospitalization and death among participants with pre-existing mental disorders adjusting for key socio-demographic covariates (i.e., age, gender, race, ethnicity, residence, smoking). Co-occurrence of any two clusters was positively associated with COVID-19-related hospitalization and death. The odds ratio of being hospitalized was 2.50 (95%CI 2.284, 2.728) for patients with internalizing and externalizing disorders, 3.34 (95%CI 2.637, 4.228) for internalizing and thought disorders, 3.29 (95%CI 2.288, 4.733) for externalizing and thought disorders, and 3.35 (95%CI 2.604, 4.310) for three clusters of mental disorders.Conclusions and RelevancePre-existing internalizing disorders, externalizing disorders, and thought disorders are positively related to COVID-19 hospitalization and death. Co-occurrence of any two clusters of mental disorders have elevated risk of COVID-19-related hospitalization and death compared to those with a single cluster.
Characterization of raloxifene as potential pharmacological agent against SARS-CoV-2 and its variants
Authors: Iaconis Daniela , Talarico Carmine , Manelfi Candida , Cesta Maria Candida , Zippoli Mara , Caccuri Francesca , Matusali Giulia , Bordi Licia , Scorzolini Laura , Bucci Enrico , Caruso Arnaldo , Nicastri Emanuele , Allegretti Marcello , Beccari Andrea Rosario 
Published: October 2021

The new coronavirus that emerged, called SARS-CoV-2, is the causative agent of the COVID-19 pandemic. The identification of potential drug candidates that can rapidly enter clinical trials for the prevention and treatment of COVID-19 is an urgent need, despite the recent introduction of several new vaccines for the prevention and protection of this infectious disease, which in many cases becomes severe. Drug repurposing (DR), a process for studying existing pharmaceutical products for new therapeutic indications, represents one of the most effective potential strategies employed to increase the success rate in the development of new drug therapies. We identified raloxifene, a known Selective Estrogen Receptor Modulator (SERM), as a potential pharmacological agent for the treatment of COVID-19 patients. Following a virtual screening campaign on the most relevant viral protein targets, in this work we report the results of the first pharmacological characterization of raloxifene in relevant cellular models of COVID-19 infection. The results obtained on all the most common viral variants originating in Europe, United Kingdom, Brazil, South Africa and India, currently in circulation, are also reported, confirming the efficacy of raloxifene and, consequently, the relevance of the proposed approach.Taken together, all the information gathered supports the clinical development of raloxifene and confirms that the drug can be proposed as a viable new option to fight the pandemic in at least some patient populations. The results obtained so far have paved the way for a first clinical study to test the safety and efficacy of raloxifene, just concluded in patients with mild to moderate COVID-19.
Diverse northern Asian and Jomon-related genetic structure discovered among socially complex Three Kingdoms period Gaya region Koreans
Authors: Gelabert Pere , Blazyte Asta , Chang Yongjoon , Fernandes Daniel M. , Jeon Sungwon , Hong Jin Geun , Yoon Jiyeon , Ko Youngmin , Oberreiter Victoria , Cheronet Olivia , Özdoğan Kadir T. , Sawyer Susanna , Yang Songhyok , Greytak Ellen McRae , Choi Hansol , Kim Jungeun , Kim Jong-Il , Bae Kidong , Bhak Jong , Pinhasi Ron 
Published: October 2021

AbstractThe genetic history of prehistoric and protohistoric Korean populations is not well understood due to the lack of ancient Korean genomes. Here, we report the first paleogenomic data from Korea; eight shotgun-sequenced genomes (0.7×∼6.1× coverage) from two archeological sites in Gimhae: Yuha-ri shell mound and Daesung-dong tumuli, the most important funerary complex of the Gaya confederacy. All eight individuals are from the Korean Three Kingdoms period (4th-7th century CE), during which there is archaeological evidence of extensive trade connections with both northern (modern-day China) and eastern (modern-day Japan) kingdoms. All genomes are best modeled as an admixture between a northern-Chinese Iron Age genetic source and a Japanese-Jomon-related ancestry. The proportion of Jomon-related ancestry suggests the presence of two genetic groups within the population. The observed substructure indicates diversity among the Gaya population that is not related to either social status or sex.Teaser1,700-year-old genomes reveal the genetic diversity of ancient Koreans in the Gimhae region.
Interleukin 7 receptor drives Early T lineage Progenitor expansion
Authors: Paiva Rafael A. , Martins Vera C. 
Published: October 2021

AbstractInterleukin 7 (IL-7) and IL-7 receptor (IL-7r) are essential for T lymphocyte differentiation, by driving proliferation and survival of specific developmental stages. While early T lineage progenitors (ETP), the most immature thymocyte population known, have a history of IL-7r expression, it is unclear whether IL-7r is required at this stage. Here, we show that mice lacking IL-7 or IL-7r have a marked loss of ETPs that results mostly from a cell-autonomous defect in proliferation and survival, although no changes were detected in Bcl2 protein levels. Further, a fraction of ETPs responded to IL-7 stimulation ex vivo by phosphorylating Stat5, and IL-7r was enriched in the most immature Flt3+Ccr9+ ETPs. Consistently, IL-7 promoted the expansion of Flt3+ but not Flt3-ETPs on OP9-DLL4 cocultures, without affecting differentiation at either stage. Taken together, our data show that IL-7/IL-7r is necessary following thymus seeding, by promoting proliferation and survival of the most immature thymocytes.SummaryPaiva et al. show that IL-7/IL-7r signaling upon thymus seeding is essential for proliferation and survival of the most immature early T lineage progenitors (ETP), thereby determining the physiological ETP cellularity.
The influence of Hofstede’s cultural dimension on tax compliance behaviour of tax practitioners
Authors: Seno Rohaida , Hashim Hafiza Aishah , Taha Roshaiza , Abdul Hamid Suhaila 
Published: October 2021

PurposeThe purpose of this paper is to determine whether Hofstede’s cultural dimensions have a significant relationship with ethical decision-making among tax practitioners while performing their duties in ensuring tax compliance among taxpayers.Design/methodology/approachA structured questionnaire was used to collect data from tax practitioners in the state of Terengganu, Malaysia. Two hundred questionnaires were distributed via Google Forms and email to tax practitioners who were selected from the Inland Revenue Board of Malaysia website using a mixture of systematic random and snowball sampling approaches. The Statistical Package for Social Sciences software program was used to analyse the collected data.FindingsThe results show that power distance (PD), individualism (IND) and uncertainty avoidance (UAV) have a significant relationship with ethical decision-making, whereas masculinity (MAS) has no significant relationship with ethical decision-making among tax practitioners while carrying out their duties. The positive relationship of PD and of IND with decision-making behaviour indicates that ethical decision-making is highly practised in a low PD and low IND culture rather than in a high PD and high IND culture. In contrast, UAV shows a negative beta sign, which indicates that tax practitioners tend to practise ethical decision-making in a high UAV culture.Originality/valueThis study fills a gap in the literature in regard to the influence of culture on tax compliance particularly among tax practitioners in Malaysia. The study shows how culture is related to the decision-making practices of tax practitioners while performing their role as an intermediary between their clients and the government. It is worthwhile to examine the decision-making of tax practitioners because the results of such an examination not only provide some insights into the professional practices of accountants that will be of interest to the relevant authorities such as the Malaysian Institute of Accountants, they also offer some information that will be of assistance to higher learning institutions in formulating accounting programmes to produce the future generation of accountants.
Guest editorialNovel and overlooked techniques for public management research questions
Authors: Malatesta Deanna , Smith Craig 
Published: October 2021

PurposeThis article provides a snapshot of several innovative and underused methodological approaches employed by scholars from across public management.Design/methodology/approachA comparative review of methodological approaches to public management research is used.FindingsThe authors find evidence of scholars applying numerous novel methodological approaches to study social science phenomena, including agent-based modeling, nonparametic approaches, social network analysis, Granger equations and techniques for correcting selection bias.Research limitations/implicationsThe review does not cover all of the innovative methodological approaches used in social science. However, the methodological techniques showcased offer promise for advancing public management research, whether used as primary applications or as one of multiple methods (triangulation) to test the validity of research findings and/or to more comprehensively understand the phenomena being studied.Originality/valueThe techniques reviewed include example applications to aid researchers who may wish to apply them in their own research. The novel tools and methods already in use by public management researchers contradict the perception that public management methods have lagged behind other social science disciplines.
Improving the port selection process during military deployments
Authors: Longhorn Dave C. , Muckensturm Joshua R. , Baybordi Shelby V. 
Published: October 2021

PurposeThis paper recommends new criteria for selecting seaports of embarkation during military deployments. Most importantly, this research compares the current port selection criterion, which is to select the seaport with the shortest inland transport time from the deploying installation, to the proposed port selection criteria, which are to select the seaport based on the shortest combined inland and oceanic transit time to the destination theater.Design/methodology/approachThe authors construct an original integer program to select seaports that minimize the expected delivery timeline for a set of notional, but realistic, deployment requirements. The integer program is solved considering the current as well as the proposed port selection criteria. The solutions are then compared using paired-samplest-tests to assess the statistical significance of the port selection criteria.FindingsThis work suggests that the current port selection criterion results in a 10–13% slower delivery of deploying forces as compared to the proposed port selection criteria.Research limitations/implicationsThis work assumes deterministic inland transit times, oceanic transit times, and seaport processing rates. Operational fluctuations in transit times and processing rates are not expected to change the findings from this research.Practical implicationsThis research provides evidence that the current port selection criterion for selecting seaports for military units deploying from the Continental United States is suboptimal. More importantly, logistics planners could use these recommended port selection criteria to reduce the expected delivery timelines during military deployments.Originality/valueSeveral military doctrinal references suggest that planners select seaports based on habitual installation-to-port pairings, especially for early deployers. This work recommends a change to the military's current port selection process based on empirical analyses that show improvements to deployment timelines.
Financial constraints and tax planning activity: empirical evidence from Ghanaian banking sector
Authors: Seidu Baba Adibura , Queku Yaw Ndori , Carsamer Emmanuel 
Published: October 2021

PurposeThis paper focused on financial constraints scenario and tax planning activities of banks in Ghana. The study explores how financial constraints could motivate the banks to pursue tax planning mechanism and the implication on tax revenue mobilisation.Design/methodology/approachThe paper followed generalised method of moments and fixed effect estimators to investigate the financial constrained-tax planning activity nexus. Simulation approach is adopted to provide financially constrained bank scenario. Besides contemporaneous analysis, sensitivity analysis is conducted to determine time varying effect. Data from all the 20 commercial banks which have operated from 2008 to 2018 were used.FindingsThe paper found that when banks are faced with financial constraints, they exhibit lower cash-effective-tax-rate. The decomposition analysis also revealed that financially constrained banks are likely to take on both short- and long-term tax planning opportunities. The paper also found evidence of persistence in the tax planning activities under financial constrained scenario.Originality/valueThis paper is one of the few studies which have extended the tax planning literature to the Ghanaian banking sector. Further novelty is seen from the development of financial constraint scenario from liquidity and solvency. Liquidity and solvency are the anchors for continuity of banking operation and sensitive to regulatory watch and sanctions. Therefore, by applying simulation approach to trigger financial constraints scenarios from these fundamental indicators reveals the extent to which commercial banks rely on tax planning opportunities to mitigate the consequence of financial constraints.
Impact of personality factors on purchase and adoption of consumer durables with advanced technology
Authors: Bhat Ullal Manohar , Bapat Dhananjay , Mookerjee Amit 
Published: October 2021

Purpose
The purpose of this paper is to identify critical personality traits affecting and influencing buying behaviour in high involvement consumer durables. It also intends to guide practitioners in selecting appropriate marketing frameworks, consumer segments and processes considering the characteristics of consumer behaviour in developing economies.

Design/methodology/approach
It systematically reviews the literature on consumer personality traits, its measurement and related consumer buying behaviour. It uses data collected from potential car buyers at various car showrooms across the Indian subcontinent. The authors have worked with the online survey firm Qualtrics, to gather a data set of 328 car purchase intenders’ responses to their validated survey. The model was tested using the SmartPLS.

Findings
The personality traits of imagination, agreeableness and social factors positively influenced attitude towards automobiles with advanced technology. Further, in line with the theory of planned behaviour, it is seen that a positive attitude towards advanced technology and design for automobiles makes a person more willing to pay for the same.

Research limitations/implications
The study is confined to consumers intending to purchase a car, who are Indian residents.

Originality/value
It adds to the comparatively lesser body of study on the impact of personality traits on intentions and attitudes in high involvement consumer durable purchases. Further, it serves as an empirical examination of the adoption of new technologies, in the context of high involvement consumer durables. For practicing managers, it provides a reference for deciding future development directions and approaches related to the effective market launch strategies and commercialization of advanced technology automobiles in India.
Transcendent service management
Authors: Watson Richard Thomas , Pitt Leyland F. 
Published: October 2021

PurposeThis vision article alerts service managers to the potential of cognitive computing to reframe their value propositions. Humans are bounded in three ways: perception, rationality and physicality. Cognitive computing, hardware or software that transcends these three limits, offers many opportunities to improve the performance of service systems, in particular those focused on customer engagement. The intangibility spectrum is presented as a mental model for service managers to consider how to use cognitive computing to support augmenting their value proposition by moving across the spectrum.Design/methodology/approachThree frameworks are integrated: a five systems framework, a system's impact classification of types of cognitive computing and a tangibility spectrum.FindingsThree examples illustrate the potential value of this integrative approach for service management.Originality/valueThis is the first integration of these frameworks, and two of them are the result of the first author's research.
Toward a diagnostic method of organizational health based on traditional Chinese medicine
Authors: Tarride Mario Iván , Contreras Mario Italo 
Published: October 2021

PurposeThe paper aims to propose a model and a comprehensive diagnostic method of organizational health status based on traditional Chinese medicine (TCM).Design/methodology/approachThe methodology is qualitative/interpretive and uses of the concept of functional homomorphism of WR Ashby is used, establishing similarities between the way in which this ancient medicine considers the human being and their condition as healthy to transfer it to an organization that produces goods and/or services.FindingsA healthy organization is conceived as one constituted by an association of people regulated by a set of norms based on certain purposes in a state of harmonious balance of their physical and energetic dimensions. In that the physical refers to storage functions, regulation and allocation of resources; transformation of raw materials and inputs into goods and services; waste disposal, distribution and coordination and with information systems for management control, while energy is associated with the ability to act with its management and policies.Research limitations/implicationsThe current paper is a first theoretical proposal, which should be enriched with practical applications that feedback its conceptual formulation, thus contributing to its validation.Practical implicationsA comprehensive organizational diagnostic method is made available.Social implicationsThe proposed method allows a comprehensive organizational diagnosis, considering the participation of all the actors that make up this type of social systems.Originality/valueAlthough the methodological resource is old, the way it is used here is considered original, and it is also part of an original investigative process by the authors, oriented toward the search for comprehensive organizational diagnostic methods.