bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic influences on brain representations of natural audiovisual experiences
Authors: Nishida Satoshi , Toyoda Shunsuke , Honda Chika , Watanabe Mikio , Ollikainen Miina , Vuoksimaa Eero , Kaprio Jaakko , Nishimoto Shinji 
Published: September 2021

Abstract
Natural sensory inputs in everyday situations induce unique experiences that vary between individuals, even when inputs are identical. This experiential uniqueness stems from the representations of sensory signals in each brain. We investigated whether genetic factors control individual differences in sensory representations in the brain by studying the brain representations of natural audiovisual signals in twin-pairs. We measured the brain response to natural movies in twins using functional magnetic resonance imaging and quantified the genetic influence on the multivoxel-pattern similarity of movie clip representations between each twin. The whole-brain analysis revealed a genetic influence on the multivoxel-pattern similarity in widespread brain regions, which included the occipitotemporal sensory cortices as well as the frontoparietal association cortices and subcortical structures. Our findings suggest that genetic factors exhibit an effect on natural audiovisual signaling by controlling audiovisual representations in the brain.
Lung-protective Ventilation Combined With Pressure-controlled Ventilation Volume-guaranteed in Children Undergoing One-lung Ventilation: A Randomised Controlled Trial
Authors: Zhu Change , Zhang Saiji , Yu Shenghua , Zhang Yuting , Wei Rong 
Published: September 2021

Abstract
The purpose of study was to evaluate the effect of lung-protective ventilation (LPV) combined with PCV-VG in children undergoing OLV. Patients were randomly assigned to the LPV combined with PCV-VG group (PCV-VG) or LPV group (volume-controlled ventilation). Both groups received tidal-volume ventilation of 8 ml kg-1 body weight during two-lung ventilation, 6 ml kg‑1 during OLV, with sustained 5 cmH2O positive end-expiratory pressure.The PCV-VG group exhibited lower PIP than the LPV group at T1 (16.8±2.3 vs. 18.7±2.7, P=0.001), T2 (20.2±2.7 vs. 22.4±3.3, P=0.001), and T3 (23.8±3.2 vs. 26.36±3.7, P=0.01). Dynamic compliance was higher in the PCV-VG group at T1, T2 , and T3 (P=0.01). After anaesthesia induction, lung aeration deteriorated, but with no immediate postoperative difference in both groups. Postoperative lung aeration improved and returned to normal from 2.5 h postextubation in both groups. No differences were observed in postoperative pulmonary complications, intra-operative desaturation, hospital stay. In paediatric patients, who underwent thoracoscopic surgery, PCV-VG combined with LPV was superior to LPV in its ability to provide ventilation with lower PIP and higher dynamic compliance. However, the long-term benefits of different ventilation strategies should be further investigated.
Climatic Change and Financial Stability: Natural Disaster Impacts on Global Stock Markets
Authors: Pagnottoni Paolo , Spelta Alessandro , Flori Andrea , Pammolli Fabio 
Published: September 2021

Abstract
This paper aims to provide a comprehensive study of the impacts of worldwide climatic change and consequent natural disasters on international stock markets. By means of a suited event study methodology, we investigate the effects of biological, climatological, geophysical, hydrological and metereological disasters occurred in 104 countries across the world on 27 global stock market indexes over the period 8 February 2001 to 31 December 2019. We find diverse stock market responses to natural hazard shocks depending on the type of event under consideration, as well as on the location in which the event has occurred. We discover that climatological and biological calamities are the disaster types which induce the most extreme reactions of international financial markets, followed by geophysical ones. Furthermore, the examined stock indexes are, on average, considerably responsive to shocks occurring in countries belonging to the European continent, which, overall, tend to affect in a negative way their performances. Finally, our empirical investigation sheds light on the diversification opportunities arising from the mitigation of natural catastrophe risks, by providing evidence on the sensitivity of stock indexes to disaster-specific and country-specific natural hazards. A natural disaster risk hedging strategy highlights the diversification opportunities arising from the mitigation of natural catastrophe risks, by providing evidence on the profitability of trading stock indexes hedging for specific natural hazard sources, and particularly climatological and biological ones.JEL codes: G15, G18, G41, Q54
Grafting Nanocellulose With Diethylenetriaminepentaacetic Acid and Chitosan As Additive for Enhancing Recycled OCC Pulp Fibres
Authors: Li Ao , Xu Dezhong , Zhang Mengnan , Wu Shengzhong , Li Yu , Rao Jiuping , Madyan Omar Abo , Fan Mizi 
Published: September 2021

Abstract
This paper is to develop a novel paper additive for effectively recycling old corrugated container (OCC) by functionalizing nanocellulose (NC) with diethylenetriaminepentaacetic acid (DTPA) and chitosan (CS), and investigate the reinforcing mechanisms and effect of the developed additive on the physical properties of recycled OCC pulp handsheets. The tensile, tear and bursting strength, whiteness, air permeability, tensile energy absorption of the recycled OCC handsheets are examined. Fourier transform infrared FTIR) spectroscopy, thermal gravimetric analysis (TGA) and scanning electron microscopy (SEM) are used for the chemical and microstructure characterization of both NC based additives and recycled OCC pulp paper. The results show that the functional groups, such as carboxyl, amino and hydroxyl groups on the NC based additives, can combine with the hydroxyl groups on the recycled OCC fibres to generate chemical bonds, which increase the crosslinks between fibres as well as the bonding area, thus enhancing their tensile strength and improving their recycling rate. SEM shows that the paper with NC based additives had tighter inter-fibre bonds and smaller paper pore structure. Addition of 0.2% NC-DTPA-CS additive results in optimal properties of the recycled OCC paper with an increase by 32%, 188%, 19% and 35% of tensile strength, tearing degree, breaking resistance and air permeability respectively.
Initial Experience in Staging Primary Oesophageal/Gastroesophageal Cancer with 18F-FDG PET/MRI
Authors: Sharkey Amy R , Sah Bert-Ram , Withey Samuel J , Bhuva Shaheel , Neji Radhouene , Jejeli Sami , Green Adrian , C Gary JR , Goh Vicky 
Published: September 2021

Abstract
Background18F-Fluorodesoxyglucose Positron-emission tomography magnetic resonance imaging (18F-FDG PET/MRI) may improve cancer staging by combining sensitive cancer detection with high contrast resolution and detail. We compared the diagnostic performance of 18F-FDG PET/MRI to 18F-Fluorodesoxyglucose Positron-emission tomography computed tomography (18F-FDG PET/CT )for staging oesophageal/gastroesophageal cancer.Following ethical approval and informed consent, participants with newly diagnosed primary oesophageal/gastroesophageal cancer were enrolled. Exclusions included prior/concurrent malignancy. Following 324±28 MBq 18F-FDG administration and 60-minute uptake, PET/CT was performed; immediately followed by integrated PET/MRI from skull base to mid-thigh. PET/CT was interpreted by two dual-accredited nuclear medicine physicians; PET/MRI by a dual-accredited nuclear medicine physician/radiologist and cancer radiologist in consensus. Per-participant staging was compared with the tumour board consensus staging using the McNemar test, with statistical significance at 5%. Results 22/26 participants (20 male; mean±SD age 68.8±8.7 years) completed 18F-FDG PET/CT and PET/MRI. Compared to the tumour board, the primary tumour was staged concordantly in 55% (12/22) with PET/MRI and 36% (8/22) with PET/CT; the nodal stage was concordant in 45% (10/22) with PET/MRI and 50% (11/22) with PET/CT. There was no statistical difference in PET/CT and PET/MRI staging performance (p>0.05, for T and N staging). The staging of distant metastases was concordant with the tumour board in 95% (21/22) with both PET/MRI and PET/CT. Of participants with distant metastatic disease, PET/MRI detected additional metastases in 30% (3/10). ConclusionIn this preliminary study, compared to 18F-FDG PET/CT, 18F-FDG PET/MRI showed non-significant higher concordance with T-staging, but no difference with N or M-staging. Additional metastases detected by 18F-FDG PET/MRI may be of additive clinical value.
Rational Construction of Superhydrophobic PDMS/PTW@cotton Fabric for Efficient UV/NIR Light Shielding
Authors: Huang Jianying , Shen Gang , Ni Yimeng , Ng Kim Hoong , Zhu Tianxue , Li Shuhui , Li Xiao , Cai Weilong , Chen Zhong 
Published: September 2021

Abstract
Passive daytime radiative cooling (PDRC) material has intrigued increasing attentions with its energy saving potential and smart cloth feature. In this work, PDRC cotton fabric with superhydrophobicity, ultraviolet protection and self-cleaning competency was successful constructed through the deposition chemically-stable potassium titanate whiskers (PTW) and polydimethylsiloxane (PDMS) onto cotton fibers. While featured with ultra-high contact angle of 151.9±0.9 °, the synthesized fabric marked an average temperature drop of ~5.1 ℃, bestowed to its high sunlight reflectivity of 83 % and infrared emissivity of nearly 90 %. On the other hand, real human tests further confirmed the practicality of the modified cotton fabric, with the recorded temperature drops ranged from 3.1~4.7 ℃ under direct sunlight. Such performance elucidated a significant improvement upon PTW/PDMS modification, which outperformed that of pristine cotton fabric. Surmising from these, the synthesized superhydrophobic fabric exhibits advantageous techno-economical index with its excellent performance and simple preparation, therefore manifesting limitless application potential, particularly in outdoor clothing and other facilities.
MTCS: A Method of Analyzing the Traffic Capacity of Urban Bus Lane Based on Vissim Simulation
Authors: Yuan Hongtao , Zhang Huizhen , Liu Minglei , Wang Cheng , Pan Yubiao , Wang Jing 
Published: September 2021

Abstract
As an effective method of improving the attractiveness of urban public transport and alleviating urban traffic congestion, bus lanes play an important role in the urban public transport system. The research on the capacity of bus lanes is conducive to improve the operation efficiency of urban bus roads and improve the service level of urban public transport. To obtain the maximum capacity of the bus lane, on one hand, the empirical formula can be used for theoretical calculation, and on the other hand, the simulation model can be established for analysis and verification. Based on the idea of simulation, a method using Vissim is proposed, called MTCS (Minimum Traffic Capacity Substitution Method). The method divides the bus lane into different sections by intersections and stops, establishes simulation model of the bus lane to calculate the traffic capacity of each section such as vehicle speed and flow and select the minimum traffic capacity of the sections as the traffic capacity of the bus lane, which is verified by using the road saturation. The simulation process uses the actual travel speed and traffic flow of the bus lane as evaluation indicators, with the aim of maximizing the road traffic flow while the actual speed of vehicles on the road is close to the desired speed, thus achieving the desired road traffic state. To verify and improve the effectiveness of the method, its analysis results are compared with the empirical formula, and various methods of enhancing traffic capacity are quantitatively simulated. The parameters of the simulation model are set by the actual bus lane example, and the experimental results show that by the methods of modifying the stop-station mode and the signal-lamp cycle, 10% and 14% improvements can be achieved, respectively. This has a good reference value for the construction of bus lanes and the adjustment of road facilities.
Restoration of Tanjore Paintings Using Segmentation and Inpainting Techniques
Authors: S Poornapushpakala , S BARANI , Subramoniam M. , T Vijayashree 
Published: September 2021

Abstract
India has its unique and rich cultural heritage. One such uniqueness in India is ancient paintings. Especially in South India, Tanjore paintings are very popular. These paintings are made with vibrant colours, gold, silver and precious stones. These paintings are the memorabilia of the great Chola kingdom. These paintings can be seen in great Brahadeeshwara Temple walls till now. Damages to these paintings happen due to varying environmental conditions throughout the year. Hence, preserving these heritages could be an additional source in National Cultural Museum and cultural libraries. This paper focuses towards the restoration of such ancient painting images that can be digitized and archived for the future use of aesthete.
Short-Term Outcomes of Pelvic Peritoneum Reconstruction with Barbed Suture After Laparoscopic Rectal Resection for Rectal Cancer
Authors: Wen Jing , Shen Jian , Huang Qiushi , He Shan 
Published: September 2021

Abstract
Background: Laparoscopic rectal resection may cause various surgical complications including perineal hernia and adhesive small-bowel obstruction. Pelvic peritoneum reconstruction (PPR) could prevent those complications. The aim of the study is to evaluate the short-term clinical, technical and safety outcomes of PPR using the barbed suture in laparoscopic rectal resection. Methods: This is a retrospective cohort study conducted in Chengdu second’s people hospital. Between January 2014 and December 2019, a total of 402 patients who underwent curative surgery for rectal cancer in Chengdu Second People’s Hospital were enrolled in the study. Among them, 216 patients who underwent laparoscopic rectal resection with PPR were allocated into the experimental group, and 186 patients who underwent laparoscopic rectal resection without PPR were allocated into control group. All the patients received standard preoperative and postoperative treatments. Observational indicators (1) surgical and postoperative conditions; (2) postoperative pathological examination. (3) postoperative complications. The data were represented by X ± s. t-test and X2 test were used for counting data. Results (1) Surgery condition: all patients in the two groups underwent successful surgery without conversion to open surgery. There were no differences between the two groups in terms of surgical approach, resection margin, tumor size, postoperative T-stage, postoperative N-stage, positive lymph nodes, harvest lymph nodes, perineal wound infection, perineal hernia, postoperative pneumonia, postoperative hemorrhage, presacral fluid, or abscess. The operative time, blood loss, the incidence of anastomotic leakage, and small-bowel obstruction showed a significant difference between the two groups. Conclusion We hypothesized that pelvic peritoneum reconstruction with barbed suture could improve the efficiency of intracorporeal closure of the pelvic cavity after in laparoscopic rectal resection, which can significantly reduce postoperative perineal-related complications. Further, we expect that use of the barbed sutures will reduce intra-operative stress on the endoscopic surgeon.
Effect of Treatment with Colchicine After Acute Coronary Syndrome on Major Cardiovascular Events: A Meta-Analysis of Clinical Trials
Authors: Razavi Erfan , Ramezani Akam , Kazemi Asma , Attar Armin 
Published: September 2021

Abstract
Purpose
Colchicine as an anti-inflammatory drug might be effective in the treatment of atherosclerosis, an inflammatory-based condition. The aim of this systematic review and meta-analysis was to evaluate the impact of colchicine on acute coronary syndrome (ACS).
Methods
We searched SCOPUS, PubMed, and Web of Science up to September 27, 2020. All clinical trials which evaluated the effect of colchicine on ACS patients and reported high-sensitivity C-reactive protein (hs-CRP) serum level or gastrointestinal (GI) adverse events with at least 5-day follow up or death, Myocardial infarction (MI), and stroke with at least 30-day follow up as outcomes were included.
Results
Finally, seven publications were analyzed. The results of our study revealed that colchicine has a marginally significant effect on hs-CRP attenuation. Furthermore, colchicine manifested promising results by declining the risk of stroke by 70%. However, MI and primary composite endpoint did not differ between the colchicine and non-colchicine group. Although colchicine did not significantly increase GI adverse events in the pooled analysis, the dose-dependent effect was detected. Low dose consumption can avoid GI side effects of colchicine.
Conclusion
Colchicine has shown some molecular and clinical promising results in ACS patients. The lack of effect of colchicine on MI and all-cause mortality can be partly attributed to the limitations of previous studies. Since colchicine is an inexpensive and easy-to-access drug that has shown to be safe in low-dose regimens in the clinical setting, it worth that future large-scale well-designed studies address this issue by resolving the limitations of previous research.
Translation, Cross-Cultural Adaptation, And Validation of The Japanese Version of The Patient Education Materials Assessment Tool (PEMAT)
Authors: Furukawa Emi , Okuhara Tsuyoshi , Okada Hiroko , Shirabe Ritsuko , Yokota Rie , Iye Reina , Kiuchi Takahiro 
Published: September 2021

Abstract
Background: The Patient Education Materials Assessment Tool (PEMAT) systematically evaluates the understandability and actionability of patient education materials. This study aimed to develop a Japanese version of PEMAT and verify its reliability and validity.Methods: After assessing content validation, experts scored healthcare-related leaflets and videos according to PEMAT, to verify inter-rater reliability. In validation testing with laypeople, the high-scoring material group (n=800) was presented with materials that received high ratings on PEMAT, and the low-scoring material group (n=799) with materials that received low ratings. Both groups responded to understandability and actionability of the materials and perceived self-efficacy for the recommended actions.Results: The Japanese version of PEMAT showed strong inter-rater reliability (PEMAT-P: % agreement= 87.3, Gwet’s AC1=0.83. PEMAT-A/V: % agreement=85.7%, Gwet’s AC1=.80). The high-scoring material group had significantly higher scores for understandability and actionability than the low-scoring material group (PEMAT-P: understandability 6.53 vs. 5.96, p<.001; actionability 6.04 vs. 5.49, p<.001; PEMAT-A/V: understandability 7.65 vs. 6.76, p<.001; actionability 7.40 vs. 6.36, p<.001). Perceived self-efficacy increased more in the high-scoring material group than in the low-scoring material group.Conclusions: Our study showed that materials rated highly on PEMAT were also easy for laypeople to understand and action. The Japanese version of PEMAT can be used to assess and improve the usability of patient education materials.
Validation of Somatic Cell Score-Associated SNPs from Holstein Cattle in Sudanese Butana and Butana X Holstein Crossbred Cattle
Authors: Elzaki Salma , Korkuc Paula , Arends Danny , Reissmann Monika , Rahmatalla Siham A. , Brockmann Gudrun A. 
Published: September 2021

Abstract
The Bos indicus zebu cattle Butana is the most commonly used indigenous dairy cattle breed in Sudan. In the last years, high-yielding Holstein dairy cattle were introgressed into Butana cattle to improve their milk yield and simultaneously keep their good adaption to extreme environmental conditions. With the focus on the improvement of milk production, other problems arose such as an increased susceptibility to mastitis. Thus, genetic selection for mastitis resistance should be considered to maintain healthy and productive cows. In this study, we tested 10 SNPs which had been associated with somatic cell score (SCS) in Holstein cattle for association with SCS in 37 purebred Butana and 203 Butana × Holstein crossbred cattle from Sudan. Animals were genotyped by allele-specific KASP assays and association analysis was performed using a linear mixed model. All 10 SNPs were segregating in the crossbred Butana x Holstein populations, but only 8 SNPs in Sudanese purebred Butana cattle. The SNP on chromosome 13 was suggestively associated with SCS in the Butana x Holstein crossbred population (rs109441194, 13:79,365,467, PBF = 0.054) and the SNP on chromosome 19 was significantly associated with SCS in both populations (rs41257403, 19:50,027,458, Butana: PBF=0.003, Butana x Holstein: PBF=6.2x10-16). The minor allele of both SNPs showed an increasing in SCS. Therefore, selection against the disadvantageous minor allele could be used for genetic improvement of mastitis resistance in the studied populations. However, investigations in a bigger population and across the whole genome are needed to identify additional genomic loci.
Exosomal miR-199a-5p Inhibits Tumorigenesis and Angiogenesis by Targeting VEGFA in Osteosarcoma
Authors: Zhang Lu , Cao Hongxin , Gu Guanghui , Hou Dehui , You Yunhao , Li Xiang , Chen Yunzhen , Jiao Guangjun 
Published: September 2021

Abstract
Background: ﻿Osteosarcoma (OS) is the most common primary bone malignancy in children and adolescents. microRNAs have been found to play a vital role in tumor angiogenesis. ﻿Here, we investigated the effects of miR-199a-5p on tumor growth and angiogenesis in osteosarcoma. Furthermore, the underlying molecular mechanisms and signaling pathways were explored.﻿Methods: The datasets were extracted from the Gene Expression Omnibus and the differentially expressed miRNAs (DEmiRNAs) were screened out by the GEO2R online platform. The potential target genes were predicted using the miRTarBase database. ﻿The predicted target genes were further analyzed by Gene Ontology and pathway enrichment analysis and a regulatory network of DEmiRNAs and their target genes was constructed. ﻿In addition, the effects of osteosarcoma cell derived exosomal miR-199a-5p on the proliferation, migration and neovascularization of HUVECs were evaluated by conducting EdU assays, Transwell experiments and tube formation assays. A dual-luciferase reporter assay was performed to detect whether VEGFA was the direct target of miR-199a-5p. Furthermore, in vivo xenograft models were established to further investigate the intrinsic role of miR-199a-5p in osteosarcoma tumorigenesis and angiogenesis. ﻿Results: ﻿A total of 149 DE-miRNAs were screened out, including 136 upregulated miRNAs and 13 downregulated miRNAs in human osteosarcoma plasma samples compared with normal plasma samples. A total of 1313 target genes of the top three upregulated and downregulated miRNAs were predicted. In the PPI network, the top 10 hub nodes with higher degrees were identified as hub genes, such as TP53 and VEGFA. By constructing the miRNA-hub gene network, we found that most of hub genes could be potentially modulated by miR-663a, miR-199a-5p and miR-223-3p. In addition, we found that the expression level of miR-199a-5p in exosomes derived from osteosarcoma cells was remarkably higher than the osteosarcoma cells, and the exosomes derived from osteosarcoma cells were transported to HUVECs. Overexpression of miR-199a-5p could significantly inhibited HUVEC proliferation, migration and neovascularization, whereas downregulation of miR-199a-5p expression exerted the opposite effect. Moreover, ﻿the in vivo results verified that overexpression of miR-199a-5p in osteosarcoma cells could suppress the growth and angiogenesis of tumors. Conclusion: Our results demonstrated that miR-199a-5p could be transported from osteosarcoma cells to HUVECs through exosomes, subsequently targeting VEGFA and inhibiting the growth and angiogenesis of osteosarcoma. ﻿Therefore, miR-199a-5p may act as a biomarker in the diagnosis and treatment of osteosarcoma.