bluuebunny/crossref_metadata_2025_split huggingface dataset:
A programmable bispecific nano-immuno-engager promotes T cell homing and reprograms tumour microenvironment
Authors: Zhang Lu , Bo Ruonan , Wu Yi , Li Longmeng , Zhu Zheng , Ma Ai-Hong , Xiao Wenwu , Huang Yanyu , Rojalin Tatu , Yin Xingbin , Wang Yongheng , Zhang Hongyong , Low Kelmen , Lee Kiana , Ajena Yousif , Jing Di , Zhang Dalin , Baehr Chris , Liu Ruiwu , Wang Lei , Li Yuanpei , Lam Kit 
Published: November 2021

Abstract
Immune checkpoint blockade (ICB) therapy has revolutionized clinical oncology. However, the efficacy of ICB therapy is limited by the ineffective homing of T effector (Teff) cells to tumours and the immunosuppressive tumour microenvironment (TME). Here, we report a programmable tumour cells/Teff cells bispecific nano-immuno-engager (NIE) that can circumvent these limitations to improve ICB therapy. We have developed 28 nm non-toxic peptidic micellar nanoparticles (NIE-NPs) that bind α3β1 integrin on tumour cells membrane and undergo in situ transformation on surface of tumour cells into nanofibrillar network (NIE-NFs). The nanofibrillar network persistently facilitates cytotoxic T cells’ homing to the proximity of tumour cells via activatable α4β1 integrin ligands, and also allows sustained release of resiquimod to reprogram the TME. This bispecific NIE eliminates syngeneic 4T1 breast cancer and Lewis lung cancer models in mice, when given together with anti-PD-1 antibody. The in vivo structural transformation-based supramolecular bispecific NIE represents an innovative class of programmable receptor-mediated targeted immunotherapeutics to greatly enhance ICB therapy against cancers.
Interpersonal trust in adolescents with psychiatric disorders and borderline pathology
Authors: Graves Miana , Penner Francesca , Sharp Carla 
Published: November 2021

Abstract

Background:
Adolescents with features of borderline personality disorder (BPD) may experience deficits in interpersonal trust; however, a simultaneous comparison of interpersonal trust among adolescents with BPD, other psychiatric disorders, and no psychiatric conditions (healthy controls) has never been conducted.

Objective:
The aims of this study were to 1) explore differences in interpersonal trust (emotional trust, honesty beliefs, and reliability beliefs) between these three groups, and 2) examine the incremental value of BPD features in association with interpersonal trust over and above internalizing and externalizing.

Method:
Adolescents (N = 445, 67.9% female, M

age
= 15.13) recruited from two psychiatric hospitals (psychiatric sample, n = 280) and community organizations (healthy sample, n = 165) completed measures of BPD features, interpersonal trust, and internalizing and externalizing psychopathology. Psychiatric adolescents also completed an interview assessing BPD (n = 83 BPD). ANCOVA and hierarchical linear regression were used for analyses.

Results:
Emotional trust differed significantly across all three groups, with the lowest level of emotional trust in adolescents with BPD. Reliability was also lower in the two psychiatric groups relative to healthy controls. BPD features were significantly, inversely associated with emotional trust and reliability beliefs when controlling for internalizing and externalizing pathology. Post-hoc analyses testing specificity of the three forms of trust found that lower emotional trust predicted BPD diagnosis over and above the other two forms of trust.

Conclusions:
Findings highlight emotional trust as a correlate and important target of intervention for adolescents with BPD, and add to knowledge on interpersonal trust deficits for adolescents with psychiatric disorders more broadly.
Performance assessment of six bias correction methods using observed and RCM data at upper Awash basin, Oromia, Ethiopia
Authors: Tumsa Bekan Chelkeba 
Published: November 2021

Abstract
Selecting a suitable bias correction method is important to provide reliable inputs for evaluation of climate change impact. Their influence was studied by comparing three discharge outputs from the SWAT model. The result after calibration with original RCM indicates that the raw RCM are heavily biased, and lead to streamflow simulation with large biases (NSE = 0.1, R2 = 0.53, MAE = 5.91 mm/°C, and PBIAS = 0.51). Power transformation and linear scaling methods performed best in correcting the frequency-based indices, while the LS method performed best in terms of the time series-based indices (NSE = 0.87, R2 = 0.78, MAE = 3.14 mm/°C, PBIAS = 0.24) during calibration. Meanwhile, daily translation was underestimating simulated streamflow compared with observed and was considered as the least performing method. The precipitation correction method has higher visual influence than temperature, and its performance in streamflow simulations was consistent and considerable. Power transformation and variance scaling showed highly qualified performance compared to others with indicated time series values (NSE = 0.92, R2 = 0.88, MAE = 1.58 mm/°C and PBIAS = 0.12) during calibration and validation of streamflow. Hence, PT and VARI were the dominant methods to remove bias from RCM models at Akaki River basin.
Crowdsourcing for Machine Learning in Public Health Surveillance: Lessons Learned From Amazon Mechanical Turk
Authors: Shakeri Hossein Abad Zahra , Butler Gregory P , Thompson Wendy , Lee Joon 
Published: November 2021

Background
Crowdsourcing services, such as Amazon Mechanical Turk (AMT), allow researchers to use the collective intelligence of a wide range of web users for labor-intensive tasks. As the manual verification of the quality of the collected results is difficult because of the large volume of data and the quick turnaround time of the process, many questions remain to be explored regarding the reliability of these resources for developing digital public health systems.

Objective
This study aims to explore and evaluate the application of crowdsourcing, generally, and AMT, specifically, for developing digital public health surveillance systems.

Methods
We collected 296,166 crowd-generated labels for 98,722 tweets, labeled by 610 AMT workers, to develop machine learning (ML) models for detecting behaviors related to physical activity, sedentary behavior, and sleep quality among Twitter users. To infer the ground truth labels and explore the quality of these labels, we studied 4 statistical consensus methods that are agnostic of task features and only focus on worker labeling behavior. Moreover, to model the meta-information associated with each labeling task and leverage the potential of context-sensitive data in the truth inference process, we developed 7 ML models, including traditional classifiers (offline and active), a deep learning–based classification model, and a hybrid convolutional neural network model.

Results
Although most crowdsourcing-based studies in public health have often equated majority vote with quality, the results of our study using a truth set of 9000 manually labeled tweets showed that consensus-based inference models mask underlying uncertainty in data and overlook the importance of task meta-information. Our evaluations across 3 physical activity, sedentary behavior, and sleep quality data sets showed that truth inference is a context-sensitive process, and none of the methods studied in this paper were consistently superior to others in predicting the truth label. We also found that the performance of the ML models trained on crowd-labeled data was sensitive to the quality of these labels, and poor-quality labels led to incorrect assessment of these models. Finally, we have provided a set of practical recommendations to improve the quality and reliability of crowdsourced data.

Conclusions
Our findings indicate the importance of the quality of crowd-generated labels in developing ML models designed for decision-making purposes, such as public health surveillance decisions. A combination of inference models outlined and analyzed in this study could be used to quantitatively measure and improve the quality of crowd-generated labels for training ML models.
Korea Mobile Healthcare National Program on Risk Factors of Metabolic Syndrome: A Multicenter Retrospective Study (Preprint)
Authors: Han Hyun Wook , Yang Sun-Young , Yoon Sung Soo , Lee Sang Jun , Oh Yumi , Kim Minsu , Cho Yoonjung , Kim Dong Jin , Yu Eunjung , Lee Sugeol , Nam Sangmin 
Published: November 2021

BACKGROUND

Following the confirmation of the effect of the pilot of the Korea Mobile Healthcare National Program in 2016, the program has been conducted annually since 2018 to improve the risk factors for metabolic syndrome. However, since this implementation began, the program has not been evaluated.

OBJECTIVE

The purpose of this study was to retrospectively investigate the results of the Korea Mobile Healthcare National Program in 2018 and 2019.

METHODS

Health behavior of participants with risk factors for metabolic syndrome were managed using a mobile app for 24 weeks and feedback was provided. Paired t-test and chi squared test were used for comparing results before and after 24 weeks.

RESULTS

Of the 8,712 participants enrolled in 2018, 7,619 completed the 24 weeks program while 10,990 of the 12,447 participants enrolled in 2019 completed the program. After the program, over 60% participants had improvement in one or more risk factors (63.09% in 2018, 65.85% in 2019). There was a statistically significant improvement in the proportion of participants who had each risk factor (blood pressure, fasting plasma glucose, triglyceride, high density lipoprotein cholesterol, and waist circumference) in both 2018 and 2019 (p < .001). The average value of each risk factor also improved in a positive direction.

CONCLUSIONS

This study showed that the Korea Mobile Healthcare National Program may contribute to improvement in the risk factors for metabolic syndrome.
О ХРОНОЛОГИИ МАЙКОПСКО-НОВОСВОБОДНЕНСКОЙ ОБЩНОСТИ В СВЕТЕ НОВЫХ ДАННЫХ И ДИСКУССИЙ
Authors: С.Н. Кореневский 
Published: November 2021

В статье проводится анализ радиокарбонных дат майкопско-новосвободненской общности. Особо рассматриваются даты первой трети IV тыс. до н. э., которые связаны с ранними проявлениями майкопско-новосвободненской общности (МНО). Серия таких дат включает более десятка определений, выполненных в разных лабораториях по костям животных, людей и керамике. Далее в статье рассматривается схема А. А. Иессена, в которой в 1950 г. был поставлен вопрос о раннемайкопских и позднемайкопских памятниках. Схема А. А. Иессена основывалась на типологии изделий из бронзы. Деление по керамике сейчас позволяет выделить 4 типологических варианта майкопско-новосвободненской общности. Последняя схема сопоставляется со схемой А. А. Иессена и радиокарбонными датами. В итоге представляется радиокарбонная хронология для каждого варианта. Общий вывод статьи - МНО существовала долго, а ее ранний вариант был распространен в начале - середине IV тыс. до н. э. и доживал в отдельных местах до последних веков (34-32 вв. до н. э.) IV тыс. до н. э.
The paper analyzes radiocarbon data for the Maykop-Novosvobodnaya culture. A special focus is placed on the dates of the first third of IV millennium BC related with the earliest manifestations of the Maykop-Novosvobodnaya entity. This dating series includes over a dozen of dates obtained from animal and human bones as well as ceramic samples in various laboratories. The paper also reviews a chronological sequence suggested by A. A. Iessen in 1950 that raised an issue of early Maykop and late Maykop sites. This sequence was mainly based on bronze items. Today the sequence based on ceramics makes it possible to identify four typological variants of the Maykop-Novosvobodnaya culture. The latter column is compared with Iessens sequence and radiocarbon dates. As a result, the radiocarbon chronology for each variants is presented. The research led the author to the conclusion that the Maykop-Novosvobodnaya culture existed for quite a long time, with the timeline of its earliest variant determined as the beginning and the middle of IV mill. BC. In some places it survived until the last centuries of IV mill. BC (34th - 32nd centuries BC).
BURIAL No. 154 OF THE MAYATSKIY CEMETERY
Authors: Владимиров С.И. 
Published: November 2021

В 2018 г. на Маяцком могильнике было исследовано разрушавшееся катакомбное погребение салтово-маяцкой культуры. В данной статье рассматривается обнаруженное в катакомбе захоронение, сопровождавшееся украшениями, предметами культа и орудиями труда.
In 2018 a crumbling catacomb burial attributed to the Saltovo-Mayatskiy culture was excavated in the Mayatskiy cemetery. The paper reviews the burial found in the catacomb that contained jewelry, objects of religious function and implements.
CREMATED REMAINS IN THE GROUND BURIALS FROM THE YURYEVSKAYA GORKA CEMETERY IN THE CONTEXT OF CULTURAL INTERRELATION IN THE NORTH OF EASTERN EUROPE IN MID - THIRD QUARTER OF THE FIRST Mill. AD
Authors: Клещенко Е. А. , Свиркина Н. Г. , Исланова И. В. , Куприянов Д. А. , Смирнов А. Л. , Бужилова А. П. , Добровольская М. В. 
Published: November 2021

Трупосожжение - наиболее распространенный тип погребальной обрядности в I тыс. н. э. в Северной и Центральной Европе. Изучение погребальных памятников редко сопровождается подробным анализом самих материалов кремации. Впервые представлено разностороннее исследование костных останков из семи погребений эталонного могильника памятников удомельского типа третьей четверти I тыс. н. э. - Юрьевской Горки. В погребениях идентифицированы молодые и взрослые мужчины из одиночных и парных захоронений, выявлены кости животных, определены породы деревьев, горевших в погребальном костре: дуб и сосна. Индивидуальная изменчивость изотопного состава стронция находится в границах 0,71390 - 0,71536 промилле, что может быть интерпретировано в целом как свидетельство умеренной мобильности людей, оставивших могильник. Сопоставление локализации и состояния кремированных останков в захоронениях различных культур Восточной Европы середины - второй половины I тыс. н. э. позволяет предполагать наличие общих черт в погребальной обрядности этого времени.
Cremation is the most common type of funerary rituals in Northern and Central Europe in the first millennium AD. The study of funerary sites is rarely accompanied by the analysis of cremated remains. This paper is the first to present a comprehensive study of bone remains from seven graves at the Yuryevskaya Gorka cemetery which is a reference cemetery of the Udomlya type dating to the third quarter of the first millennium. Young and adult males from individual and paired burials, animal bones were identified; wood species used in funeral pyre were determined (oak and pine). Individual variability of the strontium isotope composition is within 0,71390-0,71536 %o which may be taken to be an evidence of moderate mobility of people who have left behind this cemetery. Comparison of the distribution and conditions of cremated remains in graves attributed to various cultures of Eastern Europe in the mid - second half of the first millennium suggests common features of burial rites practiced at that time.
A BRIDLE PLATE FROM THE TOWN OF BEKESSAMSON. NEW DATA ON THE RESEARCH OF ARCHAEOLOGICAL SITES DATING TO THE PRE-SCYTHIAN - EARLY SCYTHIAN AGE IN THE SOUTH OF THE CARPATHIAN BASIN
Authors: Хорват В. , Рожа З. 
Published: November 2021

Работа посвящена анализу распространения одного из редких вариантов уздечных блях типа обнаруженной в окрестности г. Бекешшамшон в Юго-Восточной Венгрии. В ходе рассмотрения аналогий блях, найденных в памятниках Хорватии, Сербии и Северо-Западного Кавказа, подробно изучены сопровождающие находки и обстоятельства обнаружения. В результате можно прийти к выводу, что изучаемый бронзовый предмет датируется не ранее начала - первой половины VII в. до н. э. В ходе рассмотрения мелких деталей находки обращается внимание также на недостаточно разработанную типологию деталей уздечного набора и терминологию для описания их функционального назначения.
This paper analyzes the distribution of one of the rare variants of horse bridle plates found in the vicinities of the town of Bekessamson in Southeastern Hungary. Considering the analogies to the plates discovered at the sites in Croatia, Serbia and the Northwestern Caucasus, accompanying finds and circumstances surrounding the finds were carefully examined. As a result, we come to the conclusion that the bronze object, studied by the authors cannot be dated earlier than the beginning - the first half of the 7 c. BC. While carefully examining small parts of the find, attention is paid to insufficiency of typology of the horse bridle details and terminology used for describing their functional purpose.
COINS FROM THE BOSPORAN NECROPOLIS OF VOLNA 1 ON THE TAMAN PENINSULA
Authors: Абрамзон М. Г. , Цокур И. В. 
Published: November 2021

В статье публикуются нумизматические материалы из раскопок боспорского некрополя античного времени Волна 1 в 2014-2018 гг. Монеты являются важными хронологическими индикаторами как для датировки погребений, так и для периодизации истории некрополя в целом. За исключением единственного серебряного пантикапейского диобола (ок. 425-400 гг. до н. э.), все найденные монеты медные. Из 119 монет 117 отчеканены в Пантикапее, одна - в Фанагории, еще одна принадлежит чекану Левкона II. Позднейшая монета относится к митридатовскому времени и отчеканена после 95 г. до н. э. Все монеты использованы в качестве оболов Харона или дара, брошенного в могилу при засыпке участниками церемонии (нет ни одной, представляющей монисто), и являются важным свидетельством как погребального обряда, так и денежного обращения эпохи.
The article publishes coins from the excavations of the Bosporan necropolis of «Volna 1» in 2014-2018. Coins are important chronological indicators for both the dating of burials and the periodization of the Volna 1 Necropolis' history as a whole. Except from a single silver Panticapaeum diobol of ca. 425-400 BC, all the remain coins are copper. Of the 119 coins, 117 were minted in Panticapaeum, one in Phanagoria, and another is the Leukon II's striking. The later coin belongs to the Mithradatic period and was minted after 95 BC. All coins were used as «obols of Charon» and provide an important evidence of both the funeral rite and the currency of the epoch.
THE BUSHARINO HILLFORT ON THE SETUN RIVER AND ITS RESOURCE AREA
Authors: Кренке Н. А. , Абрамзон М. Г. , Ганичев К. А. , Ершова Е. Г. , Кудрявцев А. А. , Лазукин А. В. , Лавриков М. В. , Пронин М. И. , Чаукин С. Н. , Янишевский Б. Е. 
Published: November 2021

В статье представлены результаты новых работ на городище Бушарино в Московской области и результаты палеоботанических исследований в его ближайших окрестностях. Удалось уточнить датировку находок на городище, скорректировать атрибуцию римской медной монеты, найденной еще в 1957 г., снять высокоточный план памятника, который относится к особому типу трехвальных городищ, не адаптированных к рельефу. Выявлены некоторые расхождения в хронологии массового материала (III в. до н. э. - III в. н. э.) и даты римской монеты (IV в.). Изучение погребенных почв под древнерусским курганом в 2 км от городища и отложений торфа в ближайшем болоте (1,5 км) позволило установить, что эти участки прошли через несколько циклов подсечного земледелия в I тыс. до н. э. - первых веках н. э., таким образом удалось достоверно зафиксировать следы земледельческой активности железного века.
The paper presents results of recent studies at the Busharino hillfort in the Moscow region as well as results of paleobotanical studies in its vicinities. The chronology of finds originating from the hillfort was specified, the attribution of the Roman copper coin found back in 1957 was clarified. A high precision plan of the site was performed. The site is attributed to a special type of three-rampart hillforts not adapted to the terrain. Some discrepancies in the chronology of mass finds (3 century BC - 3 century AD) and the date of the Roman coin (4 century AD) were identified. The study of buried soils under the Medieval Russia kurgans situated two kilometers away from the hillfort as well as peat deposits in the nearest marsh (1,5 km) were undertaken. These made it possible to establish that these areas had gone through several slash-and-burn agricultural cycles in I mill. BC - first centuries AD providing, therefore, reliable evidence of agricultural activities.
Small Stone Two-Sided Icon with Prominent Carved Images of Saint Nikolaos of Myra and Saint Thomas (Preprint)
Authors: А.Н. ХОХЛОВ 
Published: November 2021

В публикации приведены некоторые результаты изучения каменной резной двусторонней иконки с изображением святителя Николая Мирликийского и св. апостола Фомы с пояснительными надписями, обнаруженной при раскопках Тверского кремля. Изготовление иконки на основании анализа аналогий и данных палеографии предварительно отнесено к XIII в.
The article represents some results of studying a small stone two-sided icon with carved images of Saint Nikolaos of Myra and Saint Thomas the Apostle and descriptive notes that was found during the excavation at Tver Kremlin site. Analyses of similar icons and paleography data allow to approximately date it back to the XIII century.
ROCK ART OF TUVA: IMAGES, SUBJECTS, COMPOSITIONS
Authors: Вл.А. Семёнов , М.Е. Килуновская 
Published: November 2021

В наскальном искусстве Тувы представлен определенный набор образов, сюжетов и композиций, характерный для каждого хронологического периода, который придает определенное своеобразие данному региону Центральной Азии. Безусловно, есть много общего с соседними регионами. Для образов и сюжетов есть определенные иконографические схемы, а в композициях устойчивая встречаемость отдельных элементов. Это позволяет говорить об их определенной семантической значимости, а значит, о возможности интерпретации, используя древние нарративные источники, этнографические параллели и аллюзии из других изобразительных текстов. Образы это козлы, олени, кони/лошади, кабаны, хищники, быки, антропоморфные фигуры, колесницы. Сюжеты сочетания олень и оленуха , олень и охотник , козлы идут по дороге и т.п. Композиции сочетание нескольких сюжетов на одной плоскости: сцены терзания, преследования, охоты, шествия животных и т.д.
Rock art of Tuva is featured with a specific set of images, subjects and compositions, typical for each chronological period which gives a certain identity to this part of Central Asian region. Of course there are a lot of similarities with neighboring rock art areas. Images and subjects follow to the certain iconographic schemes. Constant occurrence of details presents in compositions. This allows us to speak about certain semantic meaning of those compositions and due to that about possible interpretations, using ancient narrative sources, ethnographic parallels and allusions from another graphic texts. Most common images include animal figures such as goats, deer, horses, wild boars, predators and bulls, as well as anthropomorphic figures and chariots. Subjects are like stag and fawn, deer and a hunter, goats walking by the path and others. Compositions mean conjunction of several subjects within a single rock panel scenes of torment, chasing, hunting, processions of walking animals, etc.