bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of capabilities of the nanoindentation test in the determination of flow stress characteristics of the matrix material in porous sinters
Authors: Madej Lukasz , Legwand Adam , Setty Mohan , Mojzeszko Mateusz , Perzyński Konrad , Roskosz Stanislaw , Chrapoński Jacek 
Published: December 2021

Abstract
Herein, we evaluate the nanoindentation test capabilities in the determination of flow stress characteristics of the matrix material in porous sinters. The Distaloy AB sample with 15% porosity after the sintering operation is selected as a case study for the investigation. 2D and 3D imaging techniques are employed first to highlight difficulties in identifying reliable nano hardness measurement zones for further properties evaluation. Then, nanoindentation test results are acquired with Berkovich tip pressed under various loads at different locations in the sample. Systematic indentations in the quartz sample are used as a cleaning procedure to minimize the effect of the possible build-up around the indenter tip. The representative indentation load range is selected based on the extracted material characteristics. With that, the stress–strain response of the sinter matrix material is identified. The reliability of the determined flow stress curve is confirmed with the use of conical nanoindentation measurement results and finite element simulations. Obtained results show that it is possible to calculate reliable flow stress characteristics of the matrix in the porous samples, with the assumption that experiments under various loading conditions and from various locations in the matrix are performed. It is also pointed out that various indentation loads should be used to eliminate the influence of the pile-up or scale effects that affect the overall material response.
Router and gateway node placement in wireless mesh networks for emergency rescue scenarios
Authors: Wzorek Mariusz , Berger Cyrille , Doherty Patrick 
Published: December 2021

AbstractThe focus of this paper is on base functionalities required for UAV-based rapid deployment of an ad hoc communication infrastructure in the initial phases of rescue operations. The main idea is to use heterogeneous teams of UAVs to deploy communication kits that include routers, and are used in the generation of ad hoc Wireless Mesh Networks (WMN). Several fundamental problems are considered and algorithms are proposed to solve these problems. The Router Node Placement problem (RNP) and a generalization of it that takes into account additional constraints arising in actual field usage is considered first. The RNP problem tries to determine how to optimally place routers in a WMN. A new algorithm, the RRT-WMN algorithm, is proposed to solve this problem. It is based in part on a novel use of the Rapidly Exploring Random Trees (RRT) algorithm used in motion planning. A comparative empirical evaluation between the RRT-WMN algorithm and existing techniques such as the Covariance Matrix Adaptation Evolution Strategy (CMA-ES) and Particle Swarm Optimization (PSO), shows that the RRT-WMN algorithm has far better performance both in amount of time taken and regional coverage as the generalized RNP problem scales to realistic scenarios. The Gateway Node Placement Problem (GNP) tries to determine how to locate a minimal number of gateway nodes in a WMN backbone network while satisfying a number of Quality of Service (QoS) constraints.Two alternatives are proposed for solving the combined RNP-GNP problem. The first approach combines the RRT-WMN algorithm with a preexisting graph clustering algorithm. The second approach, WMNbyAreaDecomposition, proposes a novel divide-and-conquer algorithm that recursively partitions a target deployment area into a set of disjoint regions, thus creating a number of simpler RNP problems that are then solved concurrently. Both algorithms are evaluated on real-world GIS models of different size and complexity. WMNbyAreaDecomposition is shown to outperform existing algorithms using 73% to 92% fewer router nodes while at the same time satisfying all QoS requirements.
Transonic industrial wind tunnel testing in the 2020s
Authors: Greenwell D.I. 
Published: December 2021

AbstractWind tunnels remain an essential element in the design and development of flight vehicles. However, graduates in aerospace engineering tend to have had little exposure to the demands of industrial experimental work, particularly at high speed, a situation exacerbated by a lack of up-to-date reference material. In an attempt to fill this gap, this paper presents an overview of the current and near-term status and usage of transonic industrial wind tunnels. The review is aimed at recent entrants to the field, with the aim of helping them make the step from research projects in small university facilities to commercial projects in large industrial facilities. In addition, a picture has emerged from the review that contradicts received wisdom that the wind tunnel is in decline. Globally, the industrial transonic wind tunnel is undergoing somewhat of a renaissance. Numbers are increasing, investment levels are rising, capabilities are being enhanced, and facilities are busy.
Reviewing the impacts of climate change on air transport operations
Authors: Gratton G. B. , Williams P. D. , Padhra A. , Rapsomanikis S. 
Published: December 2021

AbstractClimate change is increasing global-mean tropospheric temperatures, but the localised trends are uneven, including cooling the lower stratosphere and lifting the tropopause. The wind speeds are also being modified, both at the surface and aloft. A further effect, additional to wind and temperature alone, is of increasing fluctuations and severity of extreme weather. These are impacting air transport, and this will continue. The effects are known to include increased take-off distances where excess runway lengths exist and reduced payloads where they do not, increased en-route flight times, increased frequency and severity of encounters with clear air turbulence in some regions, changed patterns of wildlife — particularly bird — activity in some regions (potentially also for other anthropogenic reasons) are shifting locations of flight safety hazards, and increased burdens upon airport and associated infrastructure. There is increasing understanding and acknowledgment by companies and authorities of these effects and the importance of mitigating them, although this is not universal and there are as yet no universally understood best practices for air transport climate change mitigation.
The Essential Role of Statistical Inference in Evaluating Electoral Systems: A Response to DeFord et al.
Authors: Katz Jonathan N. , King Gary , Rosenblatt Elizabeth 
Published: December 2021

AbstractKatz, King, and Rosenblatt (2020, American Political Science Review 114, 164–178) introduces a theoretical framework for understanding redistricting and electoral systems, built on basic statistical and social science principles of inference. DeFord et al. (2021, Political Analysis, this issue) instead focuses solely on descriptive measures, which lead to the problems identified in our article. In this article, we illustrate the essential role of these basic principles and then offer statistical, mathematical, and substantive corrections required to apply DeFord et al.’s calculations to social science questions of interest, while also showing how to easily resolve all claimed paradoxes and problems. We are grateful to the authors for their interest in our work and for this opportunity to clarify these principles and our theoretical framework.
OCD, death anxiety, and attachment: what’s love got to do with it?
Authors: Verin Rachel E. , Menzies Rachel E. , Menzies Ross G. 
Published: December 2021

AbstractBackground:Death anxiety has been empirically implicated in obsessive compulsive disorder (OCD). Research has shown that secure attachments appear to protect against fear of death, and are also associated with reduced risk of mental illness. However, few studies have investigated the moderating effect of attachment style in the relationship between death anxiety and OCD.Aims:The present study sought to explore whether attachment style moderates the relationship between death anxiety and OCD symptoms among a treatment-seeking sample of individuals diagnosed with OCD.Method:Following a structured diagnostic interview, a number of measures were administered to 48 participants. These included the Multidimensional Fear of Death Scale, Vancouver Obsessive Compulsive Inventory, and Experiences in Close Relationships-Revised.Results:As expected, death anxiety was a strong predictor of OCD severity, and other markers of psychopathology. However, contrary to hypotheses, neither anxious nor avoidant attachment style moderated the association between fear of death and OCD severity.Conclusions:The current findings add further support to the role of death anxiety in OCD. Given the absence of a moderating effect of attachment between death fears and OCD severity, it is possible that this proposed buffer against death anxiety may potentially be insufficient in the presence of this disorder. Further research is needed to clarify whether attachment style may moderate the relationship between death anxiety and symptom severity in other disorders.
Comparison of paracetamol and diclofenac prescribing preferences for adults in primary care
Authors: Bayram Dilara , Aydin Volkan , Sanli Abdullah , Abanoz Mustafa Naci , Sibic Busra , Pala Sedat , Atac Omer , Akici Ahmet 
Published: December 2021

AbstractIntroduction:The most frequently prescribed analgesic drugs in primary care centers in Turkey are diclofenac and paracetamol, respectively. In this study, we aimed to compare paracetamol-included prescriptions (PIP) and diclofenac-included prescriptions (DIP) generated for adult patients in primary care.Methods:In this cross-sectional study, PIPs (n= 280 488) and DIPs (n= 337 935) created for adults by systematic sampling among primary care physicians working in Istanbul in 2016 (n= 1431) were examined. The demographic characteristics, diagnoses, and additional drugs in PIPs and DIPs were compared.Results:Women constituted the majority in both groups (69.8% and 67.9%, respectively;P< 0.05), and mean age at PIP (52.6 ± 18.8 years) was lower compared to DIP (56.3 ± 16.1 years), (P< 0.05). In single-diagnosis prescriptions, 11 of the 15 most common diagnoses in PIP were respiratory tract infections (47.9%); three pain-related diagnoses formed 4.6% of all these prescriptions. In DIP, the number of pain-related diagnoses, mostly of musculoskeletal origin, was eight (28.5%); four diagnoses (7.8%) were upper respiratory tract infections. While hypertension was the third most common diagnosis in PIP (6.1%), it was ranked first in DIP (8.0%). The percentage of prescriptions with additional analgesic (14.0% versus 18.3%,P< 0.001), proton-pump inhibitor (13.8% versus 18.4%;P< 0.001), and antihypertensive (22.0% versus 24.8%,P< 0.001) was lower in PIP compared to DIP. However, the percentage of prescriptions with antibiotics (31.3% versus 14.7%,P< 0.001) was higher in PIP.Conclusion:Paracetamol appears to be preferred mostly in upper respiratory tract infections compared to the preference of diclofenac rather in painful/inflammatory musculoskeletal conditions. The presence of hypertension among the most commonly encountered diagnoses for these analgesic drugs points to challenges in establishing the diagnosing-treatment match and indicates potential irrational prescribing practice, especially for interactions.
TEMPORAL INTERPRETATION OF MONADIC INTUITIONISTIC QUANTIFIERS
Authors: BEZHANISHVILI GURAM , CARAI LUCA 
Published: December 2021

AbstractWe show that monadic intuitionistic quantifiers admit the following temporal interpretation: “always in the future” (for$\forall $) and “sometime in the past” (for$\exists $). It is well known that Prior’s intuitionistic modal logic${\sf MIPC}$axiomatizes the monadic fragment of the intuitionistic predicate logic, and that${\sf MIPC}$is translated fully and faithfully into the monadic fragment${\sf MS4}$of the predicate${\sf S4}$via the Gödel translation. To realize the temporal interpretation mentioned above, we introduce a new tense extension${\sf TS4}$of${\sf S4}$and provide a full and faithful translation of${\sf MIPC}$into${\sf TS4}$. We compare this new translation of${\sf MIPC}$with the Gödel translation by showing that both${\sf TS4}$and${\sf MS4}$can be translated fully and faithfully into a tense extension of${\sf MS4}$, which we denote by${\sf MS4.t}$. This is done by utilizing the relational semantics for these logics. As a result, we arrive at the diagram of full and faithful translations shown in Figure 1 which is commutative up to logical equivalence. We prove the finite model property (fmp) for${\sf MS4.t}$using algebraic semantics, and show that the fmp for the other logics involved can be derived as a consequence of the fullness and faithfulness of the translations considered.
Heat stress reduces the contribution of diazotrophs to coral holobiont nitrogen cycling
Authors: Rädecker Nils , Pogoreutz Claudia , Gegner Hagen M , Cárdenas Anny , Perna Gabriela , Geißler Laura , Roth Florian , Bougoure Jeremy , Guagliardo Paul , Struck Ulrich , Wild Christian , Pernice Mathieu , Raina Jean-Baptiste , Meibom Anders , Voolstra Christian R 
Published: December 2021

Abstract
Efficient nutrient cycling in the coral-algal symbiosis requires constant but limited nitrogen availability. Coral-associated diazotrophs, i.e., prokaryotes capable of fixing dinitrogen, may thus support productivity in a stable coral-algal symbiosis but could contribute to its breakdown when overstimulated. However, the effects of environmental conditions on diazotroph communities and their interaction with other members of the coral holobiont remain poorly understood. Here we assessed the effects of heat stress on diazotroph diversity and their contribution to holobiont nutrient cycling in the reef-building coral Stylophora pistillata from the central Red Sea. In a stable symbiotic state, we found that nitrogen fixation by coral-associated diazotrophs constitutes a source of nitrogen to the algal symbionts. Heat stress caused an increase in nitrogen fixation concomitant with a change in diazotroph communities. Yet, this additional fixed nitrogen was not assimilated by the coral tissue or the algal symbionts. We conclude that although diazotrophs may support coral holobiont functioning under low nitrogen availability, altered nutrient cycling during heat stress abates the dependence of the coral host and its algal symbionts on diazotroph-derived nitrogen. Consequently, the role of nitrogen fixation in the coral holobiont is strongly dependent on its nutritional status and varies dynamically with environmental conditions.
Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands
Authors: Linossi Edmond M. , Li Kunlun , Veggiani Gianluca , Tan Cyrus , Dehkhoda Farhad , Hockings Colin , Calleja Dale J. , Keating Narelle , Feltham Rebecca , Brooks Andrew J. , Li Shawn S. , Sidhu Sachdev S. , Babon Jeffrey J. , Kershaw Nadia J. , Nicholson Sandra E. 
Published: December 2021

AbstractSuppressor of cytokine signaling (SOCS)2 protein is a key negative regulator of the growth hormone (GH) and Janus kinase (JAK)-Signal Transducers and Activators of Transcription (STAT) signaling cascade. The central SOCS2-Src homology 2 (SH2) domain is characteristic of the SOCS family proteins and is an important module that facilitates recognition of targets bearing phosphorylated tyrosine (pTyr) residues. Here we identify an exosite on the SOCS2-SH2 domain which, when bound to a non-phosphorylated peptide (F3), enhances SH2 affinity for canonical phosphorylated ligands. Solution of the SOCS2/F3 crystal structure reveals F3 as an α-helix which binds on the opposite side of the SH2 domain to the phosphopeptide binding site. F3:exosite binding appears to stabilise the SOCS2-SH2 domain, resulting in slower dissociation of phosphorylated ligands and consequently, enhances binding affinity. This biophysical enhancement of SH2:pTyr binding affinity translates to increase SOCS2 inhibition of GH signaling.
Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity
Authors: Kouba Tomas , Vogel Dominik , Thorkelsson Sigurdur R. , Quemin Emmanuelle R. J. , Williams Harry M. , Milewski Morlin , Busch Carola , Günther Stephan , Grünewald Kay , Rosenthal Maria , Cusack Stephen 
Published: December 2021

AbstractLassa virus is endemic in West Africa and can cause severe hemorrhagic fever. The viral L protein transcribes and replicates the RNA genome via its RNA-dependent RNA polymerase activity. Here, we present nine cryo-EM structures of the L protein in the apo-, promoter-bound pre-initiation and active RNA synthesis states. We characterize distinct binding pockets for the conserved 3’ and 5’ promoter RNAs and show how full-promoter binding induces a distinct pre-initiation conformation. In the apo- and early elongation states, the endonuclease is inhibited by two distinct L protein peptides, whereas in the pre-initiation state it is uninhibited. In the early elongation state, a template-product duplex is bound in the active site cavity together with an incoming non-hydrolysable nucleotide and the full C-terminal region of the L protein, including the putative cap-binding domain, is well-ordered. These data advance our mechanistic understanding of how this flexible and multifunctional molecular machine is activated.
Assessing costs of Indonesian fires and the benefits of restoring peatland
Authors: Kiely L. , Spracklen D. V. , Arnold S. R. , Papargyropoulou E. , Conibear L. , Wiedinmyer C. , Knote C. , Adrianto H. A. 
Published: December 2021

AbstractDeforestation and drainage has made Indonesian peatlands susceptible to burning. Large fires occur regularly, destroying agricultural crops and forest, emitting large amounts of CO2and air pollutants, resulting in adverse health effects. In order to reduce fire, the Indonesian government has committed to restore 2.49 Mha of degraded peatland, with an estimated cost of US$3.2-7 billion. Here we combine fire emissions and land cover data to estimate the 2015 fires, the largest in recent years, resulted in economic losses totalling US$28 billion, whilst the six largest fire events between 2004 and 2015 caused a total of US$93.9 billion in economic losses. We estimate that if restoration had already been completed, the area burned in 2015 would have been reduced by 6%, reducing CO2emissions by 18%, and PM2.5emissions by 24%, preventing 12,000 premature mortalities. Peatland restoration could have resulted in economic savings of US$8.4 billion for 2004–2015, making it a cost-effective strategy for reducing the impacts of peatland fires to the environment, climate and human health.
Fluorinated rhamnosides inhibit cellular fucosylation
Authors: Pijnenborg Johan F. A. , Rossing Emiel , Merx Jona , Noga Marek J. , Titulaer Willem H. C. , Eerden Nienke , Veizaj Raisa , White Paul B. , Lefeber Dirk J. , Boltje Thomas J. 
Published: December 2021

AbstractThe sugar fucose is expressed on mammalian cell membranes as part of glycoconjugates and mediates essential physiological processes. The aberrant expression of fucosylated glycans has been linked to pathologies such as cancer, inflammation, infection, and genetic disorders. Tools to modulate fucose expression on living cells are needed to elucidate the biological role of fucose sugars and the development of potential therapeutics. Herein, we report a class of fucosylation inhibitors directly targeting de novo GDP-fucose biosynthesis via competitive GMDS inhibition. We demonstrate that cell permeable fluorinated rhamnose 1-phosphate derivatives (Fucotrim I & II) are metabolic prodrugs that are metabolized to their respective GDP-mannose derivatives and efficiently inhibit cellular fucosylation.
Wafer-scale integration of stretchable semiconducting polymer microstructures via capillary gradient
Authors: Qiu Yuchen , Zhang Bo , Yang Junchuan , Gao Hanfei , Li Shuang , Wang Le , Wu Penghua , Su Yewang , Zhao Yan , Feng Jiangang , Jiang Lei , Wu Yuchen 
Published: December 2021

AbstractOrganic semiconducting polymers have opened a new paradigm for soft electronics due to their intrinsic flexibility and solution processibility. However, the contradiction between the mechanical stretchability and electronic performances restricts the implementation of high-mobility polymers with rigid molecular backbone in deformable devices. Here, we report the realization of high mobility and stretchability on curvilinear polymer microstructures fabricated by capillary-gradient assembly method. Curvilinear polymer microstructure arrays are fabricated with highly ordered molecular packing, controllable pattern, and wafer-scale homogeneity, leading to hole mobilities of 4.3 and 2.6 cm2 V−1 s−1 under zero and 100% strain, respectively. Fully stretchable field-effect transistors and logic circuits can be integrated in solution process. Long-range homogeneity is demonstrated with the narrow distribution of height, width, mobility, on-off ratio and threshold voltage across a four-inch wafer. This solution-assembly method provides a platform for wafer-scale and reproducible integration of high-performance soft electronic devices and circuits based on organic semiconductors.
Temporal and spatial earthquake clustering revealed through comparison of millennial strain-rates from 36Cl cosmogenic exposure dating and decadal GPS strain-rate
Authors: Iezzi Francesco , Roberts Gerald , Faure Walker Joanna , Papanikolaou Ioannis , Ganas Athanassios , Deligiannakis Georgios , Beck Joakim , Wolfers Soeren , Gheorghiu Delia 
Published: December 2021

AbstractTo assess whether continental extension and seismic hazard are spatially-localized on single faults or spread over wide regions containing multiple active faults, we investigated temporal and spatial slip-rate variability over many millennia using in-situ 36Cl cosmogenic exposure dating for active normal faults near Athens, Greece. We study a ~ NNE-SSW transect, sub-parallel to the extensional strain direction, constrained by two permanent GPS stations located at each end of the transect and arranged normal to the fault strikes. We sampled 3 of the 7 seven normal faults that exist between the GPS sites for 36Cl analyses. Results from Bayesian inference of the measured 36Cl data implies that some faults slip relatively-rapidly for a few millennia accompanied by relative quiescence on faults across strike, defining out-of-phase fault activity. Assuming that the decadal strain-rate derived from GPS applies over many millennia, slip on a single fault can accommodate ~ 30–75% of the regional strain-rate for a few millennia. Our results imply that only a fraction of the total number of Holocene active faults slip over timescales of a few millennia, so continental deformation and seismic hazard are localized on specific faults and over a length-scale shorter than the spacing of the present GPS network over this time-scale. Thus, (1) the identification of clustered fault activity is vital for probabilistic seismic hazard assessments, and (2) a combination of dense geodetic observations and palaeoseismology is needed to identify the precise location and width of actively deforming zones over specific time periods.