bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fostering open innovation in SMEs: the crucial role of high-performance working systems and the mediating influence of innovative work behaviour
Authors: Çera Elona , Çera Gentjan , Matošková Jana , Ndou Valentina , Gregar Aleš 
Published: December 2024

Purpose
Owing to the growing importance of human resource practices (HRM) and open innovation (OI) in small and medium enterprises (SMEs) context, the purpose of this paper is to investigate the effect of high-performance working systems (HPWS) on inbound and outbound open innovation in SMEs through the mediating role of innovative work behaviour (IWB). Using ability-enhancing, motivation-enhancing and opportunity-enhancing (AMO) framework, this study investigates the direct and i.ndirect effects of HPWS AMO practices and SMEs open innovation through the mediation effects of IWB.

Design/methodology/approach
This study employed a random sampling method to collect data by surveying 208 participants from SMEs in high-tech manufacturing and knowledge-intensive service sectors. Partial least squares-structural equation modelling is employed to analyse the interrelationships between constructs.

Findings
The results show that ability-enhancing practices are critical HRM practices that directly influence SMEs inbound and outbound; IWB is positively and significantly related to OI approaches; IWB partially mediates the relations between AMO HPWS and inbound and outbound open innovation.

Practical implications
The effects of HPWS practices are important in fostering OI in SMEs operating in Czech Republic. In addition, IWB is a partial intermediation that strengthens the relation between AMO HPWS and inbound and outbound OI.

Originality/value
This study adds to our understanding of the direct and indirect interactions between HPWS practices, IWB and inbound and outbound open innovation in high-tech manufacturing and knowledge-intensive service SMEs in Czech Republic.
The impact of COVID-19 on the efficiency of exchange rate, stock and cryptocurrency markets
Authors: Kumar Satish , Pathak Rajesh 
Published: December 2024

PurposeWe investigate how the COVID-19 pandemic affected the efficiency of exchange rate, stock and cryptocurrency returns by analyzing a well-known calendar anomaly, the turn-of-the-month (TOM) effect.Design/methodology/approachWe define the TOM days as the final trading day of a month and the initial three trading days of the immediate next month. To understand the TOM effect, we estimate the typical ordinary least squares regression model using the Heteroskedasticity and Autocorrelation Consistent (HAC) standard errors and covariances.FindingsOur findings indicate that the returns during TOM days are significantly higher relative to those of non-TOM days. Nonetheless, our findings further reveal that the COVID-19 pandemic intensifies the TOM effect for the equity markets but weakens it for the exchange rate and Ethereum markets. We then develop a trading strategy that is found to beat the typical buy-and-hold (BH) approach.Practical implicationsBased on these results, we create a trading strategy which is found to surpass the BH strategy. Our results provide useful implications for investors and policymakers, as the considered markets can be timed by taking positions, especially based on the behavior of the TOM effect.Originality/valueFirst, this paper is the inaugural study to examine the TOM effect across equity, currency and cryptocurrency markets. Previous studies have not addressed the TOM effect in Ethereum markets. Second, our paper conducts a battery of validity tests to ensure that the studied anomaly is not confounded by erstwhile anomalies. Third, our paper explores the performance of studied anomalies both prior to and throughout the COVID-19 pandemic to gain a deeper understanding of market efficiency. Finally, we validate our findings using the Kruskal–Wallis test, free from the assumptions of normal distribution.
Exploring staff experiences of formulation processes in a secure children’s home
Authors: Lawrence Harriet , Matthews Tom , Turgoose David 
Published: December 2024

Purpose
This study aims to explore experiences of the Framework for Integrated Care's team formulation process within a secure children’s home in northern England, from the perspective of care and education staff.

Design/methodology/approach
Four focus groups were facilitated, with a total of 25 participants. The focus groups discussed a number of key areas, including: staff experiences of team formulation; the usefulness of the process; the wider impact of the process; and ways the formulation process could be developed. The data set was analysed using Rapid Qualitative Analysis (Hamilton, 2013).

Findings
Six overarching themes and a number of accompanying subthemes were developed. The six themes were: (i) new ways of understanding; (ii) enabling communication; (iii) young person should be at the centre; (iv) practical considerations; (v) developing accessibility: a systemic lens; and (vi) developing the focus.

Practical implications
Ten implications for practice within secure children’s homes and wider establishments are outlined. These relate to various aspects of the formulation process, including the preparatory work, meeting attendance, the focus of the formulation and dissemination.

Originality/value
Research within the context of secure children’s homes is expanding and has included the direct involvement of young people. To the best of the authors’ knowledge, this is the first study utilising a qualitative, focus group method to consider the experiences of team formulation from the perspective of the wider care and education staff team in a secure children’s home.
Progression of artificial intelligence/machine learning in geotechnical engineering
Authors: Shahin Mohamed 
Published: December 2024

Purpose
This short review paper aims to examine the evolution of artificial intelligence (AI)/machine learning (ML) in the realm of geotechnical engineering.

Design/methodology/approach
This paper gives a brief overview of AI/ML technology and discusses its current trend and future directions in geotechnical engineering.

Findings
Despite limitations, the use of AI/ML techniques has several significant benefits that make them powerful and practical tools in the field of geotechnical engineering.

Originality/value
This paper explored the integration of AI/ML promising technology into geotechnical design and practice and highlighted its transformative impacts in terms of benefits, limitations and potential future directions.
Salt-free-multifunctional dyeing approaches for cotton and CVC fabrics with direct and reactive dyes using chitosan and keratin
Authors: Beg Tahreem , Farrukh Maha , Naeem Farhana 
Published: December 2024

Purpose
Reactive and direct dyes are the most frequently used dyes for cotton fabrics. Cellulosic fibers pose a great affinity toward them. However, both dyes consume large quantities of salts for exhaustion; these electrolytes (salt) are discharged as effluents posing environmental problems and disorders in aquatic life. Therefore, this study aims to explore alternative approaches to minimize salt consumption.

Design/methodology/approach
For this study, the combination of chitosan and keratin, being sustainable biopolymers, are used as mordants instead of salts for the cationization of 100% cotton and chief value cotton (CVC) during dyeing with direct and reactive dyes. Color strength, exhaustion rates and color fastness to washing, rubbing and perspiration have been evaluated in this paper. In this research, keratin solution is applied on cotton and CVC (with the cotton to polyester ratio of 80%:20%) fabrics by pad-dry-cure, while chitosan solution has been applied with the exhaust method. The pretreated fabrics are dyed with both direct and reactive dyes with 2% and 4% depth of shade (DOS). The performance of the cationized fabrics with salt-free dyeing method was compared with the conventional dyeing.

Findings
The results of this study showed positive impact on exhaustion rates ranged from 19% to 69% of the values obtained without salt in 2% DOS and a range of 22%–47% in 4% DOS of reactive and direct dyes with treated samples. Color fastness to crocking results indicated the improvement of results by a factor of 0.5–1 after treatment and good wash fastnesses rating (4.5/5) were achieved for the chitosan-keratin treated fabrics equivalent to untreated samples. In addition, antimicrobial testing was performed on both treated and untreated fabrics of cotton and CVC. The results indicated that chitosan treated samples showed greater inhibition toward microbial activity as compared to keratin treated samples. Fourier transform infrared (FTIR) spectroscopy was used to identify the functional groups of chitosan and keratin treated fabric samples to confirm their presence. In the FTIR spectra, the chitosan was characterized by its hydroxyl, carbonyl and amide III peaks indicating the presence of chitosan and keratin was detected by the presence of primary amines. Scanning electron microscopy analysis was conducted in which it was visibly seen that the fibers have been coated with chitosan and keratin laid after being dyed.

Originality/value
For the first time, direct and reactive dyes are applied on chitosan and keratin-treated cotton and CVC to obtain multifunctional and eco-friendly fabrics.
An interdisciplinary approach to improve oral motor fluency and speech production
Authors: Schepp Jamie , Tsamoutales Lorilee , Yeich Richele , Amey Jonathan , Bradbury Sophie Louise , Solomon Risca 
Published: December 2024

Purpose
Precision teaching (PT) has been used to teach functional daily living skills by identifying motor movement deficits, teaching them to fluency in isolation and then practising the daily living skill. However, little research has focused on using PT strategies to teach speech. Therefore, the purpose of this study is to evaluate the effects of directly teaching component oral motor skills using tactile prompting techniques on the fluency of the oral motor component skills and the composite skill of speech production.

Design/methodology/approach
A pre/post design was used to measure the effects of oral motor exercises and tactile prompting procedures on the fluency of oral motor movements and speech production with an individual with Fragile X syndrome. Fluency timings of oral motor movements and a standardised speech assessment were conducted pre- and post-intervention. An intervention derived from speech and language therapy was adopted using behaviour analytic principles and implemented with the participant.

Findings
The pre/post fluency timing scores revealed an increase in the fluency of oral motor movements targeted during the intervention. An increase was also observed in the standardised speech assessment scores post-intervention.

Originality/value
There is very limited literature applying principles of PT to speech production. As such, the present study suggests the intervention was successful at increasing speech production by first targeting oral motor skills.
A comprehensive review on arsenic exposure and risk assessment in infants and young children diets: Health implications and mitigation interventions in a global perspective
Authors: Shu Lin , Yang Guiling , Liu Shufang , Huang Nan , Wang Ruike , Yang Mengxue , Chen Chen 
Published: December 2024

AbstractThe early stages of human development are critical for growth, and exposure to arsenic, particularly through the placenta and dietary sources, poses significant health risks. Despite extensive research, significant gaps remain in our comprehension of regional disparities in arsenic exposure and its cumulative impacts during these developmental stages. We hypothesize that infants in certain regions are at greater risk of arsenic exposure and its associated health complications. This review aims to fill these gaps by providing a comprehensive synthesis of epidemiological evidence related to arsenic exposure during early life, with an emphasis on the underlying mechanisms of arsenic toxicity that contribute to adverse health outcomes, including neurodevelopmental impairments, immune dysfunction, cardiovascular diseases, and cancer. Further, by systematically comparing dietary arsenic exposure in infants across Asia, the Americas, and Europe, our findings reveal that infants in Bangladesh, Pakistan, and India, exposed to levels significantly exceeding the health reference value range of 0.3–8 µg/kg/day, are particularly vulnerable to dietary inorganic arsenic. This comparative analysis not only highlights geographic disparities in exposure but also underscores the variability in regulatory frameworks. Finally, the review identifies early life as a critical window for dietary arsenic exposure and offers evidence‐based recommendations for mitigating arsenic contamination in infant foods. These strategies include improved agricultural practices, dietary modifications, stricter regulatory limits on arsenic in infant products, and encouragement of low‐arsenic dietary alternatives. Our work establishes the framework for future research and policy development aimed at reducing the burden of arsenic exposure from source to table and effectively addressing this significant public health challenge.
Organic acid‐assisted heat treatment enhances the xanthine oxidase inhibitory activity of Flos Sophorae Immaturus tea
Authors: Li Jun , Niu Ben , Wu Peng , Meng Xiangren , Fan Liuping 
Published: December 2024

AbstractAbundant polyphenols in Flos Sophorae Immaturus tea (FSIt) exhibited xanthine oxidase (XO) inhibitory activity. However, the XO inhibitory activity of FSIt was closely related to the processing methods. Herein, organic acids were employed as catalysts for polyphenol conversion during heat treatment and applied to enhance the XO inhibitory activity of FSIt; the potential mechanisms were clarified by polyphenols degradation and conversion analysis, omission experiment, and interaction assay. Results showed that 10% oxalic acid (OA)‐ or 10% lactic acid (LA)‐assisted heat treatment significantly increased the XO inhibition rate from 26.49% to 84.16% and 75.45%, respectively. OA‐assisted presented the high catalytic efficiency of rutin (31.56%), hyperoside (33.21%), and quercitrin (34.14%) to quercetin during heat treatment, as well as kaempferol‐3‐O‐rutinoside (20.04%) to kaempferol and narcissoside (26.04%) to isorhamnetin. The de‐glycosylation of polyphenols was the predominant reason for the enhancement of XO inhibitory activity. Moreover, the synergistic effect of chlorogenic acid and flavonoids also exhibited the ability to improve the XO inhibitory activity of FSIt.Practical ApplicationImproving the polyphenol composition of FSIt through organic acid‐assisted heat treatment, thereby enhancing its XO inhibitory activity, is a promising approach to deeply understand the relationship between processing methods and bioactivities of products, and further promote innovation in specific functional food processing technology.
Untargeted metabolite profiling reveals metabolic disorders in livers of rats with mepiquat exposure
Authors: Hu Chuanqin , Song Xinyu , Wang Jing , Sun Baoguo 
Published: December 2024

AbstractMepiquat is a contaminant produced in thermal‐processed food. It can induce spleen and liver injury. However, the mechanism that mepiquat induced hepatotoxicity remains unclear. In this study, a ultra‐performance liquid chromatography‐mass spectrometry (UPLC‐MS/MS)‐based metabolomic analysis of livers in rats was performed to explore metabolic alterations. Our results demonstrated that there were 36 differential metabolites. Eleven major disordered metabolic pathways were found. Network analysis of differential metabolites and metabolic pathways indicated that glutamic acid was a possible key upregulated metabolite. It participated in nine metabolic networks. Glutathione and l‐proline may be key downregulated metabolites. They were involved in eight and seven metabolic pathways, respectively. Compared with the control group, serum concentrations of alanine aminotransferase, aspartate aminotransferase, and total bile acid in high dosage group increased significantly. In addition, histopathological analysis showed liver injury in rats with mepiquat exposure. These data were consistent with results of metabolomics. Our results offered new insights for molecular mechanism of liver toxicity induced by mepiquat.Practical ApplicationMepiquat is a contaminant formed in thermal‐processed food. It can induce spleen and liver injury. Our results offered new insights for molecular mechanism of liver toxicity induced by mepiquat. It will provide important information for official limits of mepiquat in foods.
The fermentation of Cordyceps militaris polysaccharide influenced gut bacterial LPS structure formation and changed its antigenicity
Authors: Zhu Jiahui , Chen Jieming , Chen Jiafeng , Zou Yuan , Ye Zhiwei , Wei Tao , Lin Junfang , Zheng Qianwang 
Published: December 2024

AbstractGut bacterial lipopolysaccharide (LPS) could be released into the circulatory system via the gut–liver axis and cause inflammatory immune response, while Cordyceps militaris polysaccharide (CMP40) has been reported to be effective in alleviating this inflammatory response. In this study, the effects of CMP40 gut fermentation on internal LPS structure formation and the subsequent immune response were explored. Results showed that CMP40 could change antigenicity of LPS of Vibrio parahaemolyticus, Salmonella enterica, and enterotoxigenic Escherichia coli, indicated by a reduced level of NO, IL‐1β, IL‐6, and TNF‐α. The LPS structure of these three strains were further elucidated. ESI/MS results revealed that CMP40 fermentation could alter the LPS structure by removing phosphate group from a single Kdo sugar or removing additional sided fatty acid chain. The gene expressions of enzymes that are responsible for group transfer further confirmed this structure modification process. This study focused on the regulation of polysaccharide on gut bacteria LPS and provided a new insight into health effect of CMP40.
Microstructural characterization of a wheat‐based food material using image analysis and pore network modeling during baking
Authors: Nemati Ramin , Takhar Pawan Singh 
Published: December 2024

AbstractMicrostructural properties of wheat‐based food materials change during baking. These alterations affect the final product's mechanical properties, physical attributes, and consumer satisfaction. Image processing and pore network modeling were used to analyze the variations in a cookie's microstructural properties during baking. Cookies were baked in an oven set at 184 ± 2°C for 10–60 min and then freeze‐dried. Over 1500 two‐dimensional images were collected for each sample using X‐ray micro‐computed tomography. Image processing and pore network modeling were utilized to obtain porosity, pore size distribution, tortuosity, pore coordination number, permeability, and other properties. A gas pycnometer was used to validate the obtained porosity values and calculate the solid density. Three stages of expansion, shrinkage, and subsequent expansion were observed during baking. The total porosity ranged between 0.145 and 0.373. The largest pores were observed in the 20‐min baked sample, which had a moisture content of 8.53 g/100 g solids. Cookies baked longer had more interconnected pores than the 10‐min sample, enabling them to conduct fluid at a higher rate. The absolute permeability values were between 1.75 × 10−11 m2 and 4.68 × 10−11 m2. The results suggested that porosity and pore coordination number had a similar trend as cookie permeability. Both heat and mass transfer during baking are expected to influence the development of the porous structure.Practical ApplicationUnderstanding the microstructural properties of wheat‐based food materials is expected to help the baking industry control processing conditions, final product quality, and visual texture by adjusting the baking parameters.
Indocyanine Green Fluorescence Plus Blue Dye for Sentinel Lymph Node Biopsy in Patients Undergoing Neoadjuvant Chemotherapy for Breast Cancer: A Multicenter, Prospective Cohort Study
Authors: Liu Miao , Yang Yang , Hua Bin , Feng Rui , Xu Tianyu , Wang Mengyuan , Qi Xiaowei , Cao Yingming , Zhou Bo , Tong Fuzhong , Liu Peng , Liu Hongjun , Cheng Lin , Yang Houpu , Xie Fei , Wang Siyuan , Wang Chaobin , Peng Yuan , Shen Danhua , Chen Lei , Jiang Jun , Wang Shu 
Published: December 2024

ABSTRACTBackgroundSentinel lymph node biopsy (SLNB) using radioisotope tracer plus blue dye is the gold standard after neoadjuvant chemotherapy (NAC) in initially cN1 breast cancer patients, but clinical use still has limitations. This study aims to examine diagnostic performance of dual indocyanine green (ICG) and methylene blue tracing for SLNB in patients who have completed NAC for breast cancer with initially cN1 disease.MethodsAdult women (20–80 years of age) scheduled to undergo NAC for biopsy‐proven cT0‐3N1M0 primary invasive breast cancer were consecutively enrolled in this prospective, multicenter, cohort study. Upon the completion of NAC, SLNB was conducted using ICG and methylene blue, followed by axillary lymph node dissection. The primary outcome was the detection rate (DR); secondary outcomes included the false‐negative rate (FNR) and adverse events associated with the use of tracers.ResultsA total of 156 patients were enrolled; all underwent SLNB after NAC. The median number of lymph nodes retrieved during SLNB was 3 (range: 0–11). The DR was 97.4% (152/156; 95% CI, 93.6%–99.0%). The FNR was 6.7% (4/60; 95% CI, 2.6%–15.9%). Negative predictive value was 95.7% (88/92; 95% CI, 89.4%–98.3%). In the subgroup analysis stratified by ycN status, FNR was 4.0% (1/25; 95% CI, 0.7%–19.5%) and 8.6% (3/35; 95% CI, 3.0%–22.4%) in the ycN0 and ycN+ subgroups, respectively. No allergic reaction was reported.ConclusionsSLNB with ICG plus methylene blue achieved a high DR and a very low FNR in breast cancer patients with initially cN1 disease.Trial RegistrationClinicalTrials.gov (https://www.clinicaltrials.gov/), NCT02869815
A Case of Primary Lung Adenocarcinoma With Recurrent Brain Metastasis due to Transformation to Small Cell Carcinoma During Adjuvant Atezolizumab Therapy
Authors: Kobayashi Nao , Sunaga Noriaki , Yatomi Masakiyo , Wakamatsu Ikuo , Muto Sohei , Ikota Hayato , Yamaguchi Rei , Ohtaki Yoichi , Nagashima Toshiteru , Kubo Nobuteru , Masuda Tomomi , Miura Yosuke , Tsurumaki Hiroaki , Sakurai Reiko , Koga Yasuhiko , Hisada Takeshi , Maeno Toshitaka 
Published: December 2024

ABSTRACTHistologic transformation from non‐small cell to small cell lung cancer (SCLC) is a resistance mechanism to immune checkpoint inhibitors. We report herein a case of lung adenocarcinoma who developed liver and brain metastases during adjuvant atezolizumab therapy. The patient underwent a craniotomy to resect a brain metastasis, which was pathologically diagnosed as SCLC. He subsequently received platinum‐based chemotherapy with durvalumab, resulting in sustained regression of the liver metastases. This case demonstrates a metastatic brain tumor‐acquired resistance to atezolizumab through histologic transformation from adenocarcinoma to SCLC. Therefore, rebiopsy is needed if recurrent disease appears during immune checkpoint inhibitor treatment in patients with non‐small cell lung cancer.