bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of the possibility of using cavitation microcurrents in an ultrasonic scalpel for the glaucoma treatment
Authors: Sharhorodskyi Serhii , Luhovskyi Oleksandr 
Published: December 2024

The development of new medical instruments for surgical treatment of glaucoma patients is an urgent scientific and applied task of modern mechanical engineering, since the number of visually impaired people in Ukraine due to glaucoma is growing every year. The role of intraocular pressure (IOP) as a major risk factor in the pathogenesis of glaucoma development and progression has been proven. It has been established that in glaucoma the rate of aqueous humor secretion does not change, while the outflow resistance increases in the area of ​​the trabecular meshwork, which leads to an increase in IOP. A lot of evidence indicates that the resistance to the outflow of intraocular fluid is created in the area of ​​the inner wall of the trabecular meshwork. To date, the exact structural location and molecular nature of the creation of trabecular outflow resistance in the area of ​​the inner wall of the trabecular meshwork have not been precisely established and require further study. Today, the phenomenon of ultrasonic cavitation is widely used in technology, which occurs when high-intensity ultrasonic vibrations are introduced into a liquid and provides high-quality removal of contaminants from surfaces, disinfection, fine atomization, the formation of intense microcurrents, etc. Our work investigates changes in biomechanical reactions as a result of minimally invasive glaucoma surgery - expansion of physiological pathways for the outflow of intraocular fluid (trabecular apparatus, Schlemm's canal, etc.) using procedures using ultrasonic cavitation. By modernizing the phacoemulsifier, an ultrasonic glaucoma scalpel was created, which will allow cleaning the pores of the trabecular meshwork, restoring and maintaining its elasticity, reducing resistance to the outflow of ocular fluid, and reducing intraocular pressure. The use of such a tool will help ophthalmologists perform minimally invasive interventions aimed at normalizing the level of intraocular pressure in a less invasive and safer way, which will contribute to the prevention of progression and successful treatment of glaucoma. The development of the latest medical tools will make it possible to develop individual treatment strategies based on the specific needs and severity of the disease of each patient and create a perfect system of treatment for glaucoma patients.
Advances in Therapy of Adult Patients with Acute Lymphoblastic Leukemia
Authors: Sucre Oscar , Pamulapati Saagar , Muzammil Zeeshan , Bitran Jacob 
Published: December 2024

The landscape of adult acute lymphoblastic leukemia (ALL) is dramatically changing. With very promising results seen with novel immunotherapeutics in the setting of relapsed and refractory disease, the prospect of using these agents in first line therapy has prompted the development of multiple clinical trials addressing this question. This review seeks to outline and expand the current standard of care, as well as new advances, in the treatment of adult patients with ALL, and addressing future areas of research. We expect the frontline integration of immuno-oncology agents such as bispecific T cell engagers, antibody-drug conjugates, and chimeric antigen receptor (CAR) T cells may maintain or improve outcomes in adults while also minimizing toxicity. Treatment of ALL will continue to evolve as we focus on personalized patient centered approaches.
WITHDRAWN: CGRA Implementation of HEVC Decoder Using Predictable Context Directed Pattern Matching With Efficient and Flexible Memory Architecture
Authors: Munaf S. , Bharathi A. , Jayanthi A. N. 
Published: December 2024

Abstract

The full text of this preprint has been withdrawn by the authors as it was submitted and made public without the full consent of all the authors. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Role Of Occupational Factors in Noise-Induced Hearing Loss: A Single-Center Real-World Data Study
Authors: Aliyeva Aynur , Sari Elif 
Published: December 2024

Abstract

Background: This research explores the prevalence of occupational noise-induced hearing loss (NIHL) among ENT clinic patients and the related factors. We aim to assess the prevalence of NIHL, examine noise-exposed workers' characteristics, and identify factors causing high-frequency hearing loss (HFHL).
Methods: 160 workers were divided into two groups based on noise exposure duration: less than five years and over five years. We compared hearing thresholds, demographics, hearing aid usage, and preventive measures between these groups. Audiometric evaluations gauged hearing levels at various frequencies. Demographic data, including age, gender, education, and smoking habits, were collected.
Results: Most participants were male (84.4%) and under 40 (63.1%). 44.4% had worked over 5 years, 29.4% used hearing aids, and 51.9% had tinnitus. Audiometry showed increased hearing thresholds at higher frequencies, especially 4 kHz, 6 kHz, and 8 kHz. Regression showed tinnitus and longer job durations as significant predictors of NIHL.
Conclusion: The study reveals the vulnerability of noise-exposed workers to HFHL. Tinnitus is a primary predictor, and long job durations also affect hearing. The findings underscore the importance of hearing conservation, especially for workers with tinnitus and prolonged noise exposure.
Do cats have 9 lives? Successful treatment and long follow-up of a young cat with FIP and renal lymphoma
Authors: Beekhuis Ilse , Serrano Goncalos , Almendros Angel , Giuliano Antonio 
Published: December 2024

Abstract

A 3.9-year-old male neutered cat presented with hyporexia and lethargy present for a few days. An abdominal mass was palpated on clinical examination and confirmed to be a renal mass on a computed tomography angiography (CTA) scan. Ultrasound-guided fine needle aspirates were performed, and cytological evaluation revealed a large-cell renal lymphoma. A modified COP protocol with the addition of vinblastine (COVP protocol) was started resulting in a complete response. Twenty weeks after starting chemotherapy, the cat developed, anorexia, fever, and pleural effusion. Feline infectious peritonitis (FIP) was diagnosed based on a positive RT RNA PCR test from the pleural effusion. Subcutaneous GS441524 administration led to FIP resolution. The cat did not receive any further treatment for both FIP and lymphoma and almost 5 years after the diagnosis of renal lymphoma, the cat is still alive and in remission of lymphoma and FIP.
Effects of two-year adapted physical exercise program and nutritional counselling on cardio-sarcopenia syndrome in older adults with low muscle function
Authors: Pelà Giovanna , Tagliaferri Sara , Adorni Elisa , Aiello Marina , Salvi Marco , Zucchini Irene , Calvani Riccardo , Marzetti Emanuele , Lauretani Fulvio , Niccoli Giampaolo , Maggio Marcello 
Published: December 2024

Abstract

Purpose Frail and sarcopenic older individuals are high-risk population of cardiovascular events requiring multidomain intervention. The cross-talk between cardiac and skeletal muscle mass is crucial to maintain physical independence in this specific population.
The aim of the study was to evaluate, in a selected sample of frail and sarcopenic older adults, the influence of two-year exercise program and nutritional counseling (MCI group) compared to lifestyle education (HALE group) on echocardiographic parameters and on the relationship between cardiac and skeletal muscle mass.
Methods One-hundred subjects, among those enrolled in the SPRINTT trial at Frailty Clinic of University-Hospital of Parma site, underwent cardiological examination as part of the ancillary protocol (CARDIOSPRINTT). 82 participants (46 MCI and 36 HALE) completed the protocol and attended the final visit after approximately 25 months.
Results We did not find not significant changes in the intervention group compared with HALE group. However, we captured the longitudinal effects of CV aging, including the reduction of left ventricular volume and an impairment of systolic and diastolic function of both ventricles. We found, as in the baseline, a significant relationship between LVM and SMM (r=0.571, p<0.001) suggesting the existence of cardiac muscle-skeletal muscle axis. This relationship was not independent of age, BMI or systolic blood pressure.
ConclusionOur findings suggest that among frail patients with different degree of mobility impairment a personalized exercise protocol is necessary to improve cardiac health and counteract the cardiovascular aging. The modulation of cardiac-muscle axis, is an intriguing target for preventing or delaying the cardio-sarcopenia.
Comparison of the physical characteristics of six commonly used plates in clear aligner therapy
Authors: Farhadian Nasrin , Miresmaeili Amirfarhang , Morovat Anahita , Alijani Sara , Babak Jaleh , Alafchi Behnaz 
Published: December 2024

Abstract

Objectives The study evaluated six commonly used thermoplastic materials for clear aligner therapy, focusing on their mechanical properties to identify suitable options for patient treatment.
Materials and Methods Bioart 0.75, Erkodur_al 0.8, Monoflex 0.8, Duran 0.625, Duran 0.75, and CA Pro 0.75 were selected. The three-point-bending tests in a range of 2.5 mm displacement under non-thermoformed, thermoformed, after 20 hours, and after 7 days of loaded conditions immersed in water performed. Water absorption and FTIR-ATR spectroscopy for chemical evaluation were measured. Plate thickness was assessed before and after thermoforming. Statistical analyses were performed using descriptive statistics, one-way ANOVA and Tukey-Kramer multiple comparison tests.
Results FTIR-ATR analyses revealed similar spectral profiles for all materials. Monoflex exhibited the greatest variation in thickness post-thermoforming. Water absorption increased after thermoforming and immersion. Erkodur_al showed higher absorption at 20 hours and Duran 0.75 at 7 days. CA Pro 0.75 demonstrated superior long-term stability in elastic modulus and force compared to other aligners, while Duran 0.75 maintained greater force after 20 hours and 7 days at 0.25 mm displacement.
Conclusions The mechanical characteristics of thermoforming plates and the type of tooth movement are essential for selecting the right plastic material. CA Pro 0.75, with its lower force deflection rate and reduced elastic modulus, is ideal for reducing the number of aligners and increasing patient comfort.
Clinical Relevance By evaluating the physical properties of the plates, clinicians can select the most suitable plate for specific treatment objectives.
Intravenous iron supplement improves anemia in patients with colorectal cancer and iron deficiency anemia before and after surgery: a propensity score matching analysis
Authors: Maruyama Tetsuro , Ohira Gaku , Tochigi Toru , Okada Koichiro , Hirata Atsushi , Matsubara Hisahiro 
Published: December 2024

Abstract

Purpose
Iron deficiency anemia (IDA) affects approximately 50% of patients with colorectal cancer during diagnosis. Correcting IDA reduces postoperative complications, blood transfusions, and hospital stay duration. Intravenous ferric carboxymaltose (FCM) is reported to be more effective than oral iron supplements, but the evidence is limited. This study assesses the effectiveness of a single dose of FCM in improving anemia in patients with colorectal cancer before surgery.
Methods
Patients with IDA for colorectal cancer surgery received FCM approximately 14 days before surgery. Patients in the period when FCM was not used were used as the comparison group. The two groups were analyzed using propensity score matching. Clinical background and blood collection data 14 days before, 14 days after, 35 days after, and 104 days after surgery were compared using propensity score matching.
Results
Hemoglobin levels were significantly higher in the FCM group on days 14 (immediately before surgery) and 35 post-administration. Mean corpuscular volume levels were significantly higher in the FCM group on days 14, 35, and 104 post-administration. No differences were observed in postoperative complications, perioperative transfusion rates, or hospital stay duration.
Conclusions
A single administration of FCM effectively improved anemia within 14 days, with sustained effects over the long term, although no impact on postoperative outcomes was observed.
Trial registration:
This study was conducted based on the "Retrospective observational study on diagnosis and treatment of gastrointestinal diseases (Approval number: 3043, March 25, 2021)" at Chiba University School of Medicine.
Huaier Polysaccharides Targets Cancer Stem Cells in Triple-Negative Breast Cancer via ASM-mediated Autophagy-dependent Ferroptosis
Authors: Zhou Lin-xi , Wu Zi-wei , Luo Ke-fei , Zheng Hong , Tian Yuan , Pan Qin-wen , Jiang Jun , Hou Ling-mi , Wang Ming-hao 
Published: December 2024

Abstract

Background
Breast cancer stem cells (BCSCs) is critical in multiple progression of triple-negative breast cancer (TNBC). The iron concentration has been found to be higher in BCSCs. The inhibition of ferroptosis is conducive to maintaining the stemness of tumor stem cells. Despite preliminary reports indicating the effectiveness of (polysaccharides of Huaier) PS-T in the treatment of TNBC, its role and specific mechanisms in BCSCs have not been systematically studied,
Methods
LASSO regression was used to screen for stem cell-related genes that are predictive of TNBC prognosis. The effects of PS-T on TNBC stem cells were examined using ssGSEA, flow cytometry, qPCR, colony formation assays, mammosphere assays, and xenograft models. CCK-8 and GSEA analyses were performed to investigate the mechanism by which PS-T inhibited BCSCs in TNBC. PS-T-induced ferroptosis was assessed using DCF and lipid oxidation assays. Ferroptosis inhibitors were used to verify that PS-T inhibits BCSCs by activating ferroptosis. We investigated the ASM-mediated autophagic degradation of GPX4 induced by PS-T through both in vitro and in vivo assays and samples from patients with TNBC. Additionally, we confirmed these findings by inhibiting autophagy and ASM expression,
Results
A high stem-related signature risk score predicts a worse prognosis for TNBC. The proportions of ALDH+, CD44highCD24low cells, and cells with stem cell markers decreased proportionally to the dose post-PS-T therapy for TNBC. ALDH+ cells were flow-sorted and exhibited impaired stemness characteristics induced by PS-T. Moreover, the ferroptotic pathway was more active in PS-T-treated TNBC cells than in control cells. PS-T increased reactive oxygen species (ROS) and lipid oxidation levels of BCSCs. However, in the presence of ferroptosis inhibitors, PS-T did not significantly affect the growth of BSCSs. During in vitro and in vivo experiments, PS-T induces autophagic degradation of GPX4. Inhibition of autophagy reverses downregulation of GPX4, activation of ferroptosis, and suppression of BCSCs in TNBC. In addition, ASM was upregulated by PS-T and its expression was related to PS-T-induced autophagic GPX4 degradation,
Conclusions
Taken together, PS-T induced autophagy-dependent GPX4 protein degradation by upregulating ASM, thereby promoting ferroptosis and inhibiting the stemness of BCSCs, ultimately benefiting patients with TNBC.
Healthcare for LGBTQIA+ People: What Do Patients Say?
Authors: Sobral Letícia Nacle Estefan , Lima João Pedro Venancio , Silva Amanda Madureira , Monteiro Liandra Fernandes , Britto Débora Fernandes , Peixoto Raquel Autran Coelho 
Published: December 2024

Abstract

Background: Recognising sexual and gender diversity as a social marker of difference and an indicator of vulnerability in accessing comprehensive healthcare, this research aims to explore the perceptions of self-declared LGBTQIA+ people in relation to health care received in Brazil.
Methods: This was a quantitative cross-sectional observational study carried out using an anonymous online form disseminated through social media using a snowball strategy, aimed at LGBTQIA+ people living in Brazil. The instrument contained a sociodemographic questionnaire and semi-structured questions about the medical care provided and the identification of prejudiced attitudes.
Results: 134 people took part, with an average age of 30, the majority black, cisgender and homosexual. The quality of care received was positive for 35.8 per cent of the participants and 47.8 per cent reported easy access to healthcare. There was a greater perception of difficulty in access among people on low incomes when compared to people on high incomes (p < 0.05). In the healthcare environment, 31.3% said they had already suffered discrimination for being LGBTQIA+, with gynaecology being the area most frequently mentioned. 63.4% believe that there should be specific environments to meet their needs and 85% perceive that health professionals are not prepared to deal with LGBTQIA+ people.
Conclusions:There was a high prevalence of discrimination related to their sexuality in the healthcare environment, especially in gynaecological consultations. The majority of LGBTQIA+ participants believe that health professionals are not prepared to provide care to this public.
Progressive feature learning and multiplicative feature fusion network for corn disease recognition
Authors: Wang Junling , Fang Hua , Wei Wei , Zong Ping , Xu Can 
Published: December 2024

Abstract

Accurate and fast corn leaf disease recognition has attracted increasing interest in recent years, which is of great significance for promoting corn production efficiency and quality. In this paper, we propose a progressive feature learning and multiplicative feature fusion Network (PFMNet) for corn leaf disease recognition. Our approach leverages cloud services for efficient data storage, processing, and scalability. Specifically, we first develop a multi-scale feature learning module (MFLM) consisting of three parallel branches, which collaboratively learns the features from the input images, whole objects, and discriminative parts of objects in a coarse-to-fine manner. This helps discover the subtle areas of lesions and suppress the complex background noise to enhance the feature discriminability, especially for the in-field scenes with overlapped, bent and distorted corn leaves. By mapping the features at different branches to a shared latent space and producing the channel attention for each branch, we further design a multiplicative feature fusion module (MFFM), which helps aggregate different scale features in a synergistic way. Extensive experimental results quantitatively and qualitatively demonstrate the effectiveness of the proposed method, which can achieve an accuracy of 97.14% and recall of 97.36% on the corn leaf disease recognition benchmark. The integration of cloud services enhances the scalability and practicality of our solution for widespread deployment in agricultural applications.
Risk Factors for Subaxial Kyphosis After Posterior C1-C2 Fusion for Atlantoaxial Dislocation
Authors: Park Jong-Hyeok , Kang Jae-Seong , Kim Hyun Gon , Hwang Gyojun , Oh Sung Han , Hong Jae Taek 
Published: December 2024

Abstract

Purpose The objective of this study is to evaluate the change of correlation of cervical radiologic parameters after posterior C1-C2 fusion and find the risk factors for postoperative subaxial kyphosis (PSK).
Methods Medical records and radiologic data were retrospectively reviewed on patients that had undergone posterior atlantoaxial fusion for atlantoaxial dislocation (AAD) at a single center from January 2014 to December 2022. Previous cervical surgery history, concomitant with basilar invagination, additional fusion extending to occipital or subaxial spine were excluded. Patients’ demographics and radiologic parameters were evaluated for PSK. O-C1, O-C1 range of motion (ROM), C1-C2, O-C2, C2-C7, T1 slope, C2-C7 sagittal vertical axis were measured at preoperative and postoperative one year.
Results Mean age was 54.4 years, and 24 of 38 patients were women. RA was the most common pathology, account for 52.6%. Women were a significant risk factor for PSK. Patients presenting decreased O-C1 ROM was 31.6%. The incidence of PSK was 23.7%. Preoperative cervical radiologic parameters showed the sequential linkage of significant correlation from T1 slope to O-C1 angle. However, O-C1 angle was a valuable angle correlated with C2-C7 angle postoperatively. Decreased O-C1 ROM was significantly associated with PSK. The optimal postoperative C1-C2 angle ranged from 15° to 25°
Conclusions The correlation between upper cervical spine (O-C2 angle) and subaxial spine (C2-C7 angle) was not changed before and after surgery. After surgery, O-C1 angle was sequentially linked with C2-C7 angle. Women, decreased O-C1 ROM, postoperative C1-C2 angle was significantly associated with PSK.
Original Uni-portal Bi-channel and Dual-media Spinal Endoscopy system assists for transpedicular antero-dura decompression（UBD-TADD）: clinical practice and technical notes
Authors: Tian Muhang , Wu Xinbo , CHEN Fangjing , Chen Jia , Fan Yunshan , Ni Haijian , Zhao yingchuan , He Shisheng 
Published: December 2024

Abstract

Purpose：This study aimed to evaluate the clinical practice and technical efficacy of the novel Uni-portal Bi-channel and Dual-media Spinal Endoscopy system assists for transpedicular antero-dura decompression.
Methods: A retrospective, single-center review was conducted on patients who underwent UBD-TADD from August 2023 to April 2024. Comprehensive preoperative evaluations and postoperative follow-ups were performed to assess surgical outcomes.
Results: A total of 7 female patients with a mean age of 64.28±9.74 years were included. The average operation time was 245.50±21.68 minutes, with no intraoperative or postoperative complications. Patients were ambulatory the day after surgery. Blood loss was minimal, and postoperative recovery was swift. Clinical outcomes, including creatine phosphokinase 139.71 ± 22.21 vs. 115.71 ± 10.86, P= 0.351), C-reactive protein (5.14 ± 0.67 vs. 6.00 ± 0.82, P= 0.421), and white blood cell count (6.71 ± 1.11 vs. 7.29 ± 0.95, P= 0.513) levels, returned to preoperative baselines, indicating minimal surgical invasiveness. Significant improvements were observed in thoracic kyphosis, Visual Analog Scale for back (14±0.62 to 2.14±0.79, P<0.001) and leg (6.86±0.86 to 1.86±0.43, P<0.001) pain, and Oswestry Disability Index scores (42.86±4.95 to 12.57±4.21, P<0.001) postoperatively.
Conclusion: The UBD-TADD technique offers a minimally invasive, secure, and effective endoscopic approach for spinal decompression in patients with spinal cord compression from bony elements. It results in reduced surgical trauma, faster recovery, and improved functional outcomes, particularly beneficial for the elderly with osteoporosis and multiple comorbidities.