bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic value of TERF1 expression in prostate cancer
Authors: dos Santos Gabriel Arantes , Viana Nayara Izabel , Pimenta Ruan , Guimarães Vanessa Ribeiro , de Camargo Juliana Alves , Romão Poliana , Reis Sabrina T. , Leite Katia Ramos Moreira , Srougi Miguel 
Published: September 2021

Abstract
Background
Telomere dysfunction is one of the hallmarks of cancer and is crucial to prostate carcinogenesis. TERF1 is a gene essential to telomere maintenance, and its dysfunction has already been associates with several cancers. TERF1 is a target of miR-155, and this microRNA can inhibit its expression and promotes carcinogenesis in breast cancer. We aim to analyze TERF1, in gene and mRNA level, involvement in prostate cancer progression.

Results
Alterations in TERF1 DNA were evaluated using datasets of primary tumor and castration-resistant tumors (CRPC) deposited in cBioportal. The expression of TERF1 mRNA levels was assessed utilizing TCGA datasets, clinical specimens, and metastatic prostate cancer cell lines (LNCaP, DU145, and PC3). Six percent of localized prostate cancer presents alterations in TERF1 (the majority of that was amplifications). In the CRPC cohort, 26% of samples had TERF1 amplification. Patients with TERF1 alterations had the worst overall survival only on localized cancer cohort (p = 0.0027). In the TCGA cohort, mRNA levels of TERF1 were downregulated in comparison with normal tissue (p = 0.0013) and upregulated in tumors that invade lymph nodes (p = 0.0059). The upregulation of TERF1 is also associated with worst overall survival (p = 0.0028) and disease-free survival (p = 0.0023). There is a positive correlation between TERF1 and androgen receptor expression in cancer tissue (r = 0.53, p < 0.00001) but not on normal tissue (r = − 0.16, p = 0.12). In the clinical specimens, there is no detectable expression of TERF1 and upregulation of miR-155 (p = 0.0348). In cell lines, TERF1 expression was higher in LNCaP and was progressively lower in DU145 and PC3 (p = 0.0327) with no differences in miR-155 expression.

Conclusion
Amplification/upregulation of TERF1 was associated with the worst prognostic in localized prostate cancer. Our results corroborate that miR-155 regulates TERF1 expression in prostate cancer. TERF1 has the potential to become a biomarker in prostate cancer.
Aligning implementation science with improvement practice: a call to action
Authors: Leeman Jennifer , Rohweder Catherine , Lee Matthew , Brenner Alison , Dwyer Andrea , Ko Linda K. , O’Leary Meghan C. , Ryan Grace , Vu Thuy , Ramanadhan Shoba 
Published: September 2021

Abstract
Background
In several recent articles, authors have called for aligning the fields of implementation and improvement science. In this paper, we call for implementation science to also align with improvement practice. Multiple implementation scholars have highlighted the importance of designing implementation strategies to fit the existing culture, infrastructure, and practice of a healthcare system. Worldwide, healthcare systems are adopting improvement models as their primary approach to improving healthcare delivery and outcomes. The prevalence of improvement models raises the question of how implementation scientists might best align their efforts with healthcare systems’ existing improvement infrastructure and practice.

Main body
We describe three challenges and five benefits to aligning implementation science and improvement practice. Challenges include (1) use of different models, terminology, and methods, (2) a focus on generalizable versus local knowledge, and (3) limited evidence in support of the effectiveness of improvement tools and methods. We contend that implementation science needs to move beyond these challenges and work toward greater alignment with improvement practice. Aligning with improvement practice would benefit implementation science by (1) strengthening research/practice partnerships, (2) fostering local ownership of implementation, (3) generating practice-based evidence, (4) developing context-specific implementation strategies, and (5) building practice-level capacity to implement interventions and improve care. Each of these potential benefits is illustrated in a case study from the Centers for Disease Control and Prevention’s Cancer Prevention and Control Research Network.

Conclusion
To effectively integrate evidence-based interventions into routine practice, implementation scientists need to align their efforts with the improvement culture and practice that is driving change within healthcare systems worldwide. This paper provides concrete examples of how researchers have aligned implementation science with improvement practice across five implementation projects.
Docking and dynamic simulation study of Crizotinib and Temozolomide drug with Glioblastoma and NSCLC target to identify better efficacy of the drug
Authors: Younus Saleena , Vinod Chandra S. S. , Nair Achuth Sankar S. 
Published: September 2021

Abstract
Background
Crizotinib and Temozolomide are the two major chemotherapy drugs used for the treatment of cancers. Crizotinib is used as a target chemotherapy drug in many cancers. It mainly binds on the ATP binding regions of receptor tyrosine kinases (RTKs) targets and inhibits protein phosphorylation, which has already been reported. Temozolomide drug is known as the alkylating agent. Its mechanism of action is the methylation of DNA and thereby inhibiting DNA replication. However, the Temozolomide drug with protein level interaction of Glioblastoma Multiforme (GBM) and Non-small-cell lung carcinoma (NSCLC) of RTKs targets has not been reported so far. In the proposed work, we investigated the molecular level interaction of the Temozolomide drug in C-MET, C-ROS1, and ALK RTKs targets of GBM and NSCLC using an in silico study. We performed comparative analysis studies in both drugs' docked complexes based on their drug properties and complex energy (CE) to identify the better efficacy of the drug.

Results
From the docking studies,
we could identify that the Temozolomide drug bounded protein complexes showed the least complex energy. The most stable complexes were identified from these docking studies by Molecular Dynamic simulation. In the proposed study, we found that the docked complex attained a stable conformation and least energy via solid hydrogen bond interactions between the amino acid residues and the drug at the binding sites of the proteins. The least energy and the hydrogen bond interaction of Temozolomide drug with the amino acid residues of the protein complexes of C-MET, C-ROS1 and ALK protein with their id name are: 2WGJ is − 11305.0830 (PRO1158, MET1160), 3ZBF is − 11,659.6814 (MET2029, GLU2027), and 2XP2 is − 11,734.7565 (ARG1275, ASP 1160, GLU1167).

Conclusion
Our studies revealed that the Temozolomide drug bounded protein complex showed the least energy when compared to Crizotinib. So it will give better interaction on the binding sites of proteins and thereby provide better inhibition in the treatment of target therapy of GBM and NSCLC.
Antiangiogenic role of natural flavonoids and their molecular mechanism: an update
Authors: Subbaraj Gowtham Kumar , Kumar Yasam Santhosh , Kulanthaivel Langeswaran 
Published: September 2021

Abstract
Background
Angiogenesis is the development of new blood vessels from the existing vasculature, which is important in normal developmental processes. Angiogenesis is a key step in tumor growth, invasion, and metastasis. Angiogenesis is necessary for the proper nourishment and removal of metabolic wastes from tumor sites. Therefore, modulation of angiogenesis is considered a therapeutic strategy of great importance for human health.

Main body
Numerous bioactive plant compounds are recently tested for their antiangiogenic potential. Among the most frequently studied are flavonoids which are abundantly present in fruits and vegetables. Flavonoids inhibit angiogenesis and metastasis through the regulation of multiple signaling pathways. Flavonoids regulate the expression of VEGF, matrix metalloproteinases (MMPs), EGFR, and inhibit NFB, PI3-K/Akt, and ERK1/2 signaling pathways, thereby causing strong antiangiogenic effects. This present review aimed to provide up-to-date information on the molecular mechanisms of antiangiogenic properties of natural flavonoids.

Conclusion
Presently developed antiangiogenic drugs in malignant growth treatment do not meet assumptions about adequacy and safety. So further investigations are needed in this field in the future. More recently, flavonoids are the most effective antiangiogenic agent, by inhibition of signaling pathways.
Patient-Related Prognostic Factors for Anastomotic Leakage, Major Complications, and Short-Term Mortality Following Esophagectomy for Cancer: A Systematic Review and Meta-Analyses
Authors: van Kooten Robert T. , Voeten Daan M. , Steyerberg Ewout W. , Hartgrink Henk H. , van Berge Henegouwen Mark I. , van Hillegersberg Richard , Tollenaar Rob A. E. M. , Wouters Michel W. J. M. 
Published: September 2021

AbstractObjectiveThe aim of this study is to identify preoperative patient-related prognostic factors for anastomotic leakage, mortality, and major complications in patients undergoing oncological esophagectomy.BackgroundEsophagectomy is a high-risk procedure with an incidence of major complications around 25% and short-term mortality around 4%.MethodsWe systematically searched the Medline and Embase databases for studies investigating the associations between patient-related prognostic factors and anastomotic leakage, major postoperative complications (Clavien–Dindo ≥ IIIa), and/or 30-day/in-hospital mortality after esophagectomy for cancer.ResultsThirty-nine eligible studies identifying 37 prognostic factors were included. Cardiac comorbidity was associated with anastomotic leakage, major complications, and mortality. Male sex and diabetes were prognostic factors for anastomotic leakage and major complications. Additionally, American Society of Anesthesiologists (ASA) score > III and renal disease were associated with anastomotic leakage and mortality. Pulmonary comorbidity, vascular comorbidity, hypertension, and adenocarcinoma tumor histology were identified as prognostic factors for anastomotic leakage. Age > 70 years, habitual alcohol usage, and body mass index (BMI) 18.5–25 kg/m2were associated with increased risk for mortality.ConclusionsVarious patient-related prognostic factors are associated with anastomotic leakage, major postoperative complications, and postoperative mortality following oncological esophagectomy. This knowledge may define case-mix adjustment models used in benchmarking or auditing and may assist in selection of patients eligible for surgery or tailored perioperative care.
Satisfaction with care in patients with schizophrenia treated in a pilot-program model and traditional care
Authors: Hat Marta , Arciszewska-Leszczuk Aleksandra , Cechnicki Andrzej 
Published: September 2021

Cel pracyCelem badania było porównanie satysfakcji z opieki u pacjentów chorujących na schizofrenię w dwóch modelach ZLŚ: tradycyjnym i pilotażowym z równoczesną oceną nasilenia objawów i funkcjonowania społecznego.MetodaBadaniem objęto 90 pacjentów z rozpoznaniem schizofrenii leczonych w ZLŚ, 60 w modelu tradycyjnym, 30 w modelu pilotażowym. Użyto kwestionariusza danych demograficznych, skali objawów pozytywnych i negatywnych (PANSS), Skali Werońskiej oceniającej satysfakcję z leczenia (VSSS-54), kwestionariusza oceny niepełnosprawności (WHODAS), wskaźnika sieci społecznej (SNI) i skali samotności (UCLA Loneliness Scale).WynikiGrupa pilotażowa charakteryzowała się istotnie niższym wiekiem badanych (p=0,048), mniejszą liczbą zażywanych leków psychiatrycznych (p=0,027), większym nasileniem objawów całkowitych (p<0,001) i pozytywnych (p<0,001) w PANSS, mniejszą siecią społeczną (p=0,003), mniejszą aktywnością w rolach w sieci społecznej (p<0,001), wyższym poziomem samotności (p=0,001) i wyższym poziomem niepełnosprawności (p<0,001). W grupie pilotażowej uzyskano istotnie wyższą satysfakcję z włączenia rodzin w proces terapeutyczny (p = 0,024).WnioskiW grupie pilotażowej objęto leczeniem pacjentów młodszych, ciężej chorujących o większym nasileniu objawów, gorszym funkcjonowaniu społecznym przy równoczesnym braku różnic w liczbie hospitalizacji między grupami. Wstępnie można wnioskować, że ZLŚ w centrach pilotażowych chroni tę grupę pacjentów przed hospitalizacją. Stwierdzono też wyższa satysfakcje z włączenia rodziny w proces terapeutyczny w grupie pilotażowej. Wartościową kontynuacją badania byłaby ocena wyników leczenia we wszystkich ZLŚ działających w ramach pilotażowych CZP.
Drill splatter in orthopaedic procedures and its importance during the COVID-19 pandemic
Authors: Kabariti Rakan , Green Natalie , Turner Robert 
Published: September 2021

Aims During the COVID-19 pandemic, drilling has been classified as an aerosol-generating procedure. However, there is limited evidence on the effects of bone drilling on splatter generation. Our aim was to quantify the effect of drilling on splatter generation within the orthopaedic operative setting. Methods This study was performed using a Stryker System 7 dual rotating drill at full speed. Two fluid mediums (Videne (Solution 1) and Fluorescein (Solution 2)) were used to simulate drill splatter conditions. Drilling occurred at saw bone level (0 cm) and at different heights (20 cm, 50 cm, and 100 cm) above the target to simulate the surgeon ‘working arm length’, with and without using a drill guide. The furthest droplets were marked and the droplet displacement was measured in cm. A surgical microscope was used to detect microscopic droplets. Results Bone drilling produced 5 cm and 7 cm droplet displacement using Solutions 1 and 2, respectively. Drilling at 100 cm above the target produced the greatest splatter generation with a 95 cm macroscopic droplet displacement using Solution 2. Microscopic droplet generation was noticed at further distances than what can be macroscopically seen using Solution 1 (98 cm). Using the drill guide, there was negligible drill splatter generation. Conclusion Our study has shown lower than anticipated drill splatter generation. The use of a drill guide acted as a protective measure and significantly reduced drill splatter. We therefore recommend using a drill guide at all times to reduce the risk of viral transmission in the operative setting. Cite this article: Bone Jt Open 2021;2(9):752–756.
Linguoevocation research of pedagogical interpersonal communication: based on a fragment of a literary text
Authors: Malygina Eleanor 
Published: September 2021

The article is devoted to the problem of linguo-translational research of pedagogical (school) interpersonal communication, reproduced in a fragment of the text of O. Kamaeva's novel " Christmas Tree. From school with love, or The Teacher's Diary." The methodology is based on the parameter of the two-dimensional linguoevocation study of the text. The primary plan is subordinated to the category of evocativeness of a literary text. An important place belongs to the means of reproducing the model of pedagogical communication as a product of evocation. The description of the model of the depicted interpersonal interaction is made according to the parameters of the verbal communication act proposed by B. Y. Gorodetsky. The secondary plan of studying pedagogical communication is related to the category of interpretativeness of the text. The results of the study, obtained in the course of the linguistic-evocation description of interpersonal communication of the primary plan, allow the reader to see the components of the object of interpretation, to establish the relationship between the problem of the teacher's speech image and the process of effectuating the interaction of characters.
Liquidity Preference Theory or Loanable Funds Theory
Authors: Jossa Bruno 
Published: September 2021

In Keynes’s approach, interest rates are driven up by rises in demand for money and scaled down by rises in money supply. On the contrary, this paper argues that neither of these propositions will stand the test of scrutiny. Keynes traced demand for money to three main factors, the transaction, precautionary and speculative motives, but rises in demand associated with the transaction motive do not necessarily drive up the rate of interest.
The paper shows also that the liquidity preference theory and the loanable funds theory are different theories and that the former is faulty, while the latter is correct.
Bubble Detection and the Impact of Monetary Policy, Market Sentiment and Market Liquidity on Property Stock Price Index in Indonesia
Authors: Dasman Sunita 
Published: September 2021

The purpose of this study is to detect the existence of a bubble stock and analyze the impact of monetary policy, market sentiment and liquidity on the property stock index in the Indonesian capital market. The data used in this study is secondary data originating from various sources for the period 2016 – 2020 using multiple linear regressions. The bubble stock detection is done by using the ratio between the property stock price index and the consumer nutrient index.
The results showed that there was an indication of a moderate bubble stock in the property stock index during the research period 2016 – 2020. The factors that impacted the property stock price index were interest rates, the rupiah exchange rate against the US dollar, market sentiment and market liquidity. The increase in interest rates, the rupiah exchange rate, and market sentiment and liquidity has an impact on the increase in the property stock price index on the Indonesian stock exchange for the 2016 – 2020 periods.
Keywords: Bubble Stock, Exchange Rate, Interest Rate, Inflation, Market Sentiment, Market Liquidity
Does Vaccinations Reduce the COVID-19 Infection?
Authors: Fujita Yasunori 
Published: September 2021

Since the outbreak of COVID-19, each government has been struggling to find the ways of fighting off the coronavirus, with the vaccination being one of the most promising ways of doing it. In Japanese also, the government has started administering the vaccinations to the general public and is now analyzing the data from the recipients.
In the present paper, we investigate the vaccine's efficacy by building a simple intertemporal theoretical model. Main result we obtain is that administering the vaccinations can increase number of the infected individuals, contrary what is widely believed.
The Impact of Performance Based Budget (Pbb) on Projects Effectiveness, Quality and Sustainability in Fako and Meme Divisions of the South West Region, Cameroon
Authors: Anyingang Roland A. 
Published: September 2021

The study examined the impact of performance based budget on projects effectiveness, quality and sustainability in Fako and Meme Divisions of the South West Region, Cameroon. Three specific objectives were formulated to guide this study. The objectives investigated the impact of performance based budget on the effectiveness of projects, the impact of performance based budget on the quality of projects and the impact of performance based budget on the sustainability of projects. Ex-post facto research design was used for this study. The sample of this study was made up 420 respondents comprising of service providers, beneficiaries of the projects and staff of the Regional Delegation of Water and Energy and the Regional Delegation of Public Works in Fako and Meme Divisions. A well validated structured questionnaire was used for data collection. Data collected were analyzed using descriptive statistics and dependent t-test. Findings revealed that there exist a significant difference in the quality of roads, water and electricity projects before and after implementation of performance based budget with the quality of roads higher after the full implementation than before the implementation of PBB. There exist a significant difference in the effectiveness of road, water and electricity projects before and after implementation of water projects, and there exist a significant difference in the sustainability of road, water and electricity projects before and after implementation of performance based budget. The study recommended that the effectiveness of the budgetary system should be improved so that the quality and sustainability of projects will be obtained. Moreover, good budget begets good results.
Brand Betrayal: A Comprehensive Study to Examine the Indicators and Consequences of Brand Betrayal Towards Consumer Behavior
Authors: Rehmat Sana , Wasim Manahil 
Published: September 2021

Abstract
Brand betrayal is induced by the brand itself when it fails to fulfill its promised moral obligations and involves the type of behavior that fractures the strong self–brand connection with the consumers. Brand managers must come across several negative types of consumer behaviors that depict their sense of dissatisfaction. Additionally, the effort of a brand to reduce the effects of brand betrayal is reflected by the sheer amount of customer apologies and compensation paid to the affected consumers. Having a sound knowledge about the primary indicators of brand betrayal encourages the brand managers to take necessary measures to deal with the challenges of the negative consumer-brand relationship. The resultant revenge behaviors depicted by the consumers include different types of activities such as spreading negative word-of-mouth and avoiding the brand itself, customer incivility, etc. The existing literature on the consequences of brand betrayal is insufficient to build the novel theory around the construct and differentiate it from brand dissatisfaction. The current research in brand dissatisfaction argues that it is a more generalized construct than brand betrayal that becomes the immediate cause of brand avoidance. The effect of these consequences needs to be addressed by the marketing theorists and practitioners to strengthen the consumer-brand relationship and manage the longer-lasting results of negative consumer behaviors.
lecturer
Authors: Okelo Stephen 
Published: September 2021

The purpose of this study was to investigate the effects of Environmental factors on financing BOT( Build Operate Transfer) infrastructure projects, Infrastructure plays a crucial role in the drive for achieving development by providing energy, transportation, and water. There have been ups and downs in the degree of emphasis placed on infrastructure, but infrastructure has remained the largest component of the public investment programs in developing countries 62 % of gross domestic product (GDP). Nearly half of the international financial institutions’ project lending to developing countries goes to infrastructure. The study used a mixed method research design; with a target population of 720 employees of rift valley rail consortium and government of Kenya representatives of which a sample of 338. The study used questionnaires and interview guides to collect data. Data were collected by administering questionnaires to the respondents while senior managers and government officials were interviewed. Data collected was coded. Qualitative data was analyzed using themes and sub-themes, while quantitative data was analyzed by the use of inferential statistics, of which the frequency percentages were calculated, data were cross-tabulated to establish the relationship within the variables and finally, a Wald test statistic was conducted to measure the strength and direction of relationship within the variables. A calculated Pearson Chi-Square of 0.818 lead to rejection of the null hypothesis and therefore, there is a significant relationship between Environmental antecedents and financing of BOT projects. The study recommended that there is a need for policies to be articulated on tackling the rise of environmental destruction due to the BOT projects in Kenya.