bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential expression of stem cell markers in proliferating cells in glioma
Authors: Rehfeld Marten , Matschke Jakob , Hagel Christian , Willenborg Kerstin , Glatzel Markus , Bernreuther Christian 
Published: June 2021

Abstract
Purpose
The identification of prognostically and therapeutically relevant molecular markers is fundamental to the further development of personalised therapies in brain tumours. Current therapeutic options for the treatment of gliomas rely mainly on surgical resection and the inhibition of tumour cell proliferation by irradiation and chemotherapy. Glioma stem cells are a subpopulation of proliferating tumour cells that have self-renewal capacity and can give rise to heterogeneous cells that comprise the tumour and are thought to play a role in the resistance of gliomas to therapy. The aim of this study was to evaluate the expression of markers of glioma stem cells and differentiated glial cells in proliferating glioma cells in comparison to the overall expression of the respective markers in the tumour tissue.

Methods
Tissue microarrays were assembled from specimen of pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, glioblastoma, oligodendroglioma, anaplastic oligodendroglioma, ependymoma, and anaplastic ependymoma. These were immunohistochemically double stained with antibodies against the proliferation-associated antigen Ki67 and marker proteins for glioma stem cells (CD133, Nestin, Musashi, CD15, CD44), and differentiated glioma cells (GFAP, MAP2c).

Results
The expression of both glial and glioma stem cell markers differs between proliferating and non-proliferating glioma cells. Furthermore, the proliferating cells in the different glial tumour entities show a different expression profile.

Conclusion
Further analysis of marker expression in proliferating glioma cells and correlation with clinical outcome and susceptibility to irradiation and chemotherapy might help establish new biomarkers and therapies for glioma.
Bank vole alarm pheromone chemistry and effects in the field
Authors: Sievert Thorbjörn , Ylönen Hannu , Blande James D. , Saunier Amélie , van der Hulst Dave , Ylönen Olga , Haapakoski Marko 
Published: June 2021

AbstractChemical communication plays an important role in mammalian life history decisions. Animals send and receive information based on body odour secretions. Odour cues provide important social information on identity, kinship, sex, group membership or genetic quality. Recent findings show, that rodents alarm their conspecifics with danger-dependent body odours after encountering a predator. In this study, we aim to identify the chemistry of alarm pheromones (AP) in the bank vole, a common boreal rodent. Furthermore, the vole foraging efficiency under perceived fear was measured in a set of field experiments in large outdoor enclosures. During the analysis of bank vole odour by gas chromatography–mass spectrometry, we identified that 1-octanol, 2-octanone, and one unknown compound as the most likely candidates to function as alarm signals. These compounds were independent of the vole’s sex. In a field experiment, voles were foraging less, i.e. they were more afraid in the AP odour foraging trays during the first day, as the odour was fresh, than in the second day. This verified the short lasting effect of volatile APs. Our results clarified the chemistry of alarming body odour compounds in mammals, and enhanced our understanding of the ecological role of AP and chemical communication in mammals.
Conservation laws for even order elliptic systems in the critical dimension - a new approach
Authors: Hörter Jasmin , Lamm Tobias 
Published: June 2021

AbstractWe consider elliptic systems of order 2m in dimension 2m which are generalizations of extrinsic and intrinsic polyharmonic maps. We show the existence of a conservation law for these systems by using a small perturbation of Uhlenbeck’s gauge fixing matrix.
Comparison of isoflurane and propofol sedation in critically ill COVID-19 patients—a retrospective chart review
Authors: Kermad Azzeddine , Speltz Jacques , Danziger Guy , Mertke Thilo , Bals Robert , Volk Thomas , Lepper Philipp M. , Meiser Andreas 
Published: June 2021

Abstract
Purpose
In this retrospective study, we compared inhaled sedation with isoflurane to intravenous propofol in invasively ventilated COVID-19 patients with ARDS (Acute Respiratory Distress Syndrome).

Methods
Charts of all 20 patients with COVID-19 ARDS admitted to the ICU of a German University Hospital during the first wave of the pandemic between 22/03/2020 and 21/04/2020 were reviewed. Among screened 333 days, isoflurane was used in 97 days, while in 187 days, propofol was used for 12 h or more. The effect and dose of these two sedatives were compared. Mixed sedation days were excluded.

Results
Patients’ age (median [interquartile range]) was 64 (60–68) years. They were invasively ventilated for 36 [21–50] days. End-tidal isoflurane concentrations were high (0.96 ± 0.41 Vol %); multiple linear regression yielded the ratio (isoflurane infusion rate)/(minute ventilation) as the single best predictor. Infusion rates were decreased under ECMO (3.5 ± 1.4 versus 7.1 ± 3.2 ml∙h−1; p < 0.001). In five patients, the maximum recommended dose of propofol of 4 mg∙hour−1∙kg−1ABW was exceeded on several days. On isoflurane compared to propofol days, neuro-muscular blocking agents (NMBAs) were used less frequently (11% versus 21%; p < 0.05), as were co-sedatives (7% versus 31%, p < 0.001); daily opioid doses were lower (720 [720–960] versus 1080 [720–1620] mg morphine equivalents, p < 0.001); and RASS scores indicated deeper levels of sedation (− 4.0 [− 4.0 to − 3.0] versus − 3.0 [− 3.6 to − 2.5]; p < 0.01).

Conclusion
Isoflurane provided sufficient sedation with less NMBAs, less polypharmacy and lower opioid doses compared to propofol. High doses of both drugs were needed in severely ill COVID-19 patients.
Anterior artery release, distraction and fusion (ARDF) for radiculopathy caused by a vertebral artery loop
Authors: Farshad Mazda , Spirig José Miguel , Burkhard Marco D. 
Published: June 2021

Abstract
Background
Anomalous vertebral artery (VA) with loop formation is a rare cause of cervical nerve root compression. Various techniques with anterior and posterior approaches have been described for surgical treatment once conservative treatments fail. We herein present a case treated with the new technique of anterior release, distraction and fusion (ARDF) and further provide an updated review of surgically managed VA loops in the subaxial spine.

Case description
A 76-year-old female complained of a 6-year history of pulsating, shooting pain in her right arm to the thumb. After obtaining repeated MRI, the VA loop compressing the right-sided C6-nerve root was detected. A neurovascular decompression through ARDF which led to an indirect loop straightening was performed. The patient immediately improved after surgery and remained pain-free 1 year postoperative.

Conclusion
Neural irritation due to VA loop formation is a rare cause of cervical radiculopathy. While various surgical strategies have been described, we believe that anterior and anterolateral approaches are the safest to yield neurovascular decompression. We described and documented ARDF (anterior VA release, intervertebral distraction and fusion) on a patient case.

Level of evidence
II (Diagnostic: individual cross-sectional studies with consistently applied reference standard and blinding).
Frühes Mammakarzinom: Aktuelle Strategien in der System- und Radiotherapie
Authors: Schneeweiss Andreas , Huober Jens , Brucker Sara Y. , Budach Wilfried , Denkert Carsten , Fasching Peter A. , Haidinger Renate , Harbeck Nadia , Jackisch Christian , Janni Wolfgang , Krug David , Kühn Thorsten , Loibl Sibylle , Müller Volkmar , Thill Marc , Thomssen Christoph , Untch Michael , Kolberg-Liedtke Cornelia , Lüftner Diana 
Published: June 2021

Zusammenfassung
Hintergrund
Seit über 30 Jahren findet regelmäßig die internationale St.-Gallen(SG)-Konsensuskonferenz zur Behandlung des primären Mammakarzinoms (SG-BCC) statt. Bei diesem Konsens handelt es sich um ein Meinungsbild von Experten unterschiedlicher Länder und Fachdisziplinen.

Rationale
Vor diesem Hintergrund werden die Abstimmungsergebnisse des St.-Gallen-Konsensus-Panels bereits seit einigen Jahren von einer deutschen Arbeitsgruppe führender Brustkrebsexperten für den Klinikalltag in Deutschland diskutiert. Fünf der Brustkrebsexperten aus Deutschland sind zugleich Mitglieder des diesjährigen St.-Gallen-Panels.

Grundlage
Grundlage der Diskussion für den deutschen Klinikalltag sind die jährlich aktualisierten Therapieempfehlungen der Kommission Mamma der Arbeitsgemeinschaft Gynäkologische Onkologie (AGO Mamma 2021) sowie die deutsche S3-Leitlinie.

Ergebnis
Die diesjährige 17. SG-BCC stand unter dem Motto „Customizing local and systemic therapies for women with early breast cancer“ und fokussierte auf die Herausforderung, die Behandlung des frühen Mammakarzinoms zielgerichteter an die individuelle Krankheitssituation zu adaptieren. Die vorliegende Publikation diskutiert die wichtigsten Ergebnisse der SG-BCC zur System- und Radiotherapie.
Adolescent depression and adult labor market marginalization: a longitudinal cohort study
Authors: Alaie Iman , Philipson Anna , Ssegonja Richard , Copeland William E. , Ramklint Mia , Bohman Hannes , Jonsson Ulf 
Published: June 2021

AbstractAdolescent depression is linked to adult ill-health and functional impairment, but recent research suggests that individual/contextual factors might account for this association. This study aimed to test whether the clinical heterogeneity of adolescent depression is related to marginalization from the labor market across early to middle adulthood. Data were drawn from the Uppsala Longitudinal Adolescent Depression Study, a community-based cohort initially assessed with structured clinical interviews at age 16–17. The cohort (n = 321 depressed;n = 218 nondepressed) was followed up after 2+ decades through linkage to nationwide population-based registries. Outcomes included consecutive annual data on unemployment, work disability, social welfare recipiency, and a composite marginalization measure, spanning from age 21 to 40. Longitudinal associations were examined using logistic regression analysis in a generalized estimating equations modeling framework. Subsequent depressive episodes and educational attainment in early adulthood were explored as potential pathways. The results showed that adolescent depression was associated with adult marginalization outcomes, but the strength of association varied across depressed subgroups. Adolescents with persistent depressive disorder had higher odds of all outcomes, including the composite marginalization measure (adjusted OR = 2.0, 95% CI = 1.4–2.7,p < 0.001), and this was partially (31%) mediated by subsequent depressive episodes in early adulthood. Exploratory moderation analysis revealed that entry into tertiary education mitigated the association with later marginalization, but only for adolescents with episodic major depression. In conclusion, the risk for future labor market marginalization is elevated among depressed adolescents, particularly those presenting with persistent depressive disorder. Targeted interventions seem crucial to mitigate the long-lasting impact of early-onset depression.
E-cigarettes and smoking in Irish teens: a logistic regression analysis of current (past 30-day) use of e-cigarettes
Authors: Hanafin Joan , Sunday Salome , Clancy Luke 
Published: June 2021

Abstract
Aim
Electronic cigarette (e-cigarette) use among Irish teenagers has risen significantly. In 2019, prevalence of current use (last 30 days) among 15–17-year-olds was 17.3%. We examine social determinants of adolescent e-cigarette current use.

Subject and methods
A stratified random sample of 50 schools in Ireland was surveyed in 2019, part of the European School Survey Project on Alcohol and other Drugs (ESPAD), with 3495 students aged 15, 16, and 17. Bivariate and multivariable logistic regression [providing adjusted odds ratios (AORs)] analyses were performed using Stata version 16.

Results
Current e-cigarette users were more likely to be male (AOR = 0.55, 95% CI:0.32–0.96, p < .01), younger (AOR = 0.34, 95% CI: 0.17–0.67, p = < .05), to participate in sport (AOR = 2.21, 95% CI: 1.05–4.65, p < .05), to have higher-educated parents (maternal higher education: AOR = 27.54, 95% CI: 1.50–505.77, p = < .05, paternal higher education: AOR = 2.44, 95% CI: 1.00–5.91, p < .05), and less likely to consider their families better off (AOR = 0.29, 95% CI: 0.13–0.65, p < .01), or to report familial support (AOR = 0.78, 95% CI: 0.64–0.95, p < .05). They were more likely to be cigarette smokers (AOR = 7.22, 95% CI: 3.97–13.12, p < .001), to report problem cannabis use (AOR = 3.12, 95% CI: 1.40–6.93, p < .01), to be ‘binge’ drinkers (AOR = 1.81, 95% CI : 1.00–3.32, p = .054), and to have friends who get drunk (AOR = 5.30, 95% CI: 1.34–20.86, p < .05).

Conclusion
Boys, smokers, binge drinkers, problem cannabis users, and sport-playing teenagers from higher-educated families, are at particular risk. As the number of young people using e-cigarettes continues to rise, including teenagers who have never smoked, improved regulation of e-cigarettes, similar to other tobacco-related products, is needed urgently to prevent this worrying new trend of initiation into nicotine addiction.
Differential Analysis of the Years of Experience of Higher Education Teachers, their Digital Competence and use of Digital Resources: Comparative Research Methods
Authors: Guillén-Gámez Francisco. D. , Cabero-Almenara Julio , Llorente-Cejudo Carmen , Palacios-Rodríguez Antonio 
Published: June 2021

AbstractThis study compares the level of digital competence of Spanish higher education teachers in the use of three types of ICT resources in the classroom: digital tools to consume information, digital tools to produce information, and emerging technologies. To measure the level of competence, the validated DigCompEdu Check-In instrument with an ex post facto design is used. The sample consists of 2180 university teachers from Andalusia (Spain) working in different areas of knowledge: Arts and Humanities, Sciences, Health Sciences, Engineering and Architecture, Social and Legal Sciences; and classified into three levels of teaching experience: between 0–5 years, 6–14 years, and 15 years or more. The results show that teachers with 15 or more years of experience represent the group with the most significant differences in regard to their level of digital competence when comparing the use of the three types of ICT resources; furthermore, the results were similar for all areas of knowledge. In addition, the visualization or creation of videos, as well as the visualization or creation of posters and concept maps, are the resources that were found to be most significant for the three levels of experience. For each specific area, it is recommended that each of their results is analysed in detail. Finally, further research is recommended to validate these preliminary findings in each of the knowledge areas.
Legio: fault resiliency for embarrassingly parallel MPI applications
Authors: Rocco Roberto , Gadioli Davide , Palermo Gianluca 
Published: June 2021

AbstractDue to the increasing size of HPC machines, dealing with faults is becoming mandatory due to their high frequency. Natively, MPI cannot handle faults and it stops the execution prematurely when it finds one. With the introduction of ULFM, it is possible to continue the execution, but it requires complex integration with the application. In this paper we propose Legio, a framework that introduces fault resiliency in embarrassingly parallel MPI applications. Legio exposes its features to the application transparently, removing any integration difficulty. After a fault, the execution continues only with the non-failed processes. We also propose a hierarchical alternative, which features lower repair costs on large communicators. We evaluated our solutions on the Marconi100 cluster at CINECA with benchmarks and real-world applications, showing that the overhead introduced by the library is negligible and it does not limit the scalability properties of MPI.
The impact of sediment, fresh and marine water on the concentration of chemical elements in water of the ice-covered lagoon
Authors: Bełdowska Magdalena , Jędruch Agnieszka , Sieńska Dorota , Chwiałkowski Wojciech , Magnuszewski Artur , Kornijów Ryszard 
Published: June 2021

AbstractThe common use of chemical elements by man has been contributing to their extraction for centuries. As a consequence, they have been directly or indirectly introduced into the biogeochemical cycle. In the framework of many conventions, mining and processing of elements are currently subject to many restrictions. However, their large load that has already been deposited in the soil and bottom sediments can be remobilised and enter the food chain. The identification of factors favouring this process is very important, especially during the period of adopting new legal regulations on limiting the emission of pollutants. It became possible in February 2018 during the persistence of ice cover on the lagoon’s surface. This allowed observation of processes, the effect of which in the absence of ice is blurred by wind mixing water. Therefore, an investigation of sources of 25 elements in a lagoon of the southern Baltic has been undertaken, based on the example of the Vistula Lagoon. The results point to the remobilisation of chemical elements (including the toxic ones) from land and bottom sediments, where they have been deposited for decades. These processes led to the accumulation of metals in certain areas of the lagoon. It may result in their uptake and accumulation in the benthic organisms inhabiting the lagoon and further transfer in the food chain. It is of major importance as the lagoons in the southern Baltic fulfil many essential functions in the scope of tourism, economy, and fishery. Thanks to restrictions on the quality of wastewater and the emission of pollutants, it has been noticed a substantial “purifying” effect of rivers, too.
Evaluating the Effects of Opioid Prescribing Policies on Patient Outcomes in a Safety-net Primary Care Clinic
Authors: Rowe Christopher L. , Eagen Kellene , Ahern Jennifer , Faul Mark , Hubbard Alan , Coffin Phillip 
Published: June 2021

Abstract
Background
After decades of liberal opioid prescribing, multiple efforts have been made to reduce reliance upon opioids in clinical care. Little is known about the effects of opioid prescribing policies on outcomes beyond opioid prescribing.

Objective
To evaluate the combined effects of multiple opioid prescribing policies implemented in a safety-net primary care clinic in San Francisco, CA, in 2013–2014.

Design
Retrospective cohort study and conditional difference-in-differences analysis of nonrandomized clinic-level policies.

Patients
273 patients prescribed opioids for chronic non-cancer pain in 2013 at either the treated (n=151) or control clinic (n=122) recruited and interviewed in 2017–2018.

Interventions
Policies establishing standard protocols for dispensing opioid refills and conducting urine toxicology testing, and a new committee facilitating opioid treatment decisions for complex patient cases.

Main Measures
Opioid prescription (active prescription, mean dose in morphine milligram equivalents [MME]) from electronic medical charts, and heroin and opioid analgesics not prescribed to the patient (any use, use frequency) from a retrospective interview.

Key Results
The interventions were associated with a reduction in mean prescribed opioid dose in the first three post-policy years (year 1 conditional difference-in-differences estimate: −52.0 MME [95% confidence interval: −109.9, −10.6]; year 2: −106.2 MME [−195.0, −34.6]; year 3: −98.6 MME [−198.7, −23.9]; year 4: −72.6 MME [−160.4, 3.6]). Estimates suggest a possible positive association between the interventions and non-prescribed opioid analgesic use (year 3: 5.2 absolute percentage points [−0.1, 11.2]) and use frequency (year 3: 0.21 ordinal frequency scale points [0.00, 0.47]) in the third post-policy year.

Conclusions
Clinic-level opioid prescribing policies were associated with reduced dose, although the control clinic achieved similar reductions by the fourth post-policy year, and the policies may have been associated with increased non-prescribed opioid analgesic use. Clinicians should balance the urgency to reduce opioid prescribing with potential harms from rapid change.
Maternal mental health and well-being during the COVID-19 pandemic in Beijing, China
Authors: Wei Zhuang , Gao Ming-Yue , Fewtrell Mary , Wells Jonathan , Yu Jin-Yue 
Published: June 2021

Abstract
Background
The aim of this study is to evaluate the impact of the coronavirus disease 2019 (COVID-19) pandemic on breastfeeding women and to identify predictors of maternal mental health and coping.

Methods
Mothers aged ≥ 18 years with a breast-fed infant ≤ 18 months of age during the COVID-19 pandemic in Beijing, China, completed a questionnaire. Descriptive analysis of lockdown consequences was performed and predictors of these outcomes were examined using stepwise linear regression.

Results
Of 2233 participants, 29.9%, 20.0% and 34.7% felt down, lonely, and worried, respectively, during the lockdown; however, 85.3% felt able to cope. Poorer maternal mental health was predicted by maternal (younger age, higher education) and infant (older age, lower gestation) characteristics, and social circumstances (husband unemployed or working from home, receiving advice from family, having enough space for the baby, living close to a park or green space). Conversely, better maternal mental health was predicted by higher income, employment requiring higher qualifications, more personal space at home, shopping or walking > once/week and lack of impact of COVID-19 on job or income. Mothers with higher education, more bedrooms, fair division of household chores and attending an online mother and baby group > once/week reported better coping.

Conclusion
The findings highlight maternal characteristics and circumstances that predict poorer mental health and reduced coping which could be used to target interventions in any future public health emergencies requiring social restrictions.