bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faktor Risiko Early Childhood Caries pada Anak UsiaPrasekolah di PAUD Kenanga 17 Kelurahan Penjaringan, Kecamatan Penjaringan, Jakarta Utara
Authors: Rosa Delima Anita , Kusuma Arum Setya 
Published: March 2021

Dental caries is a multifactorial disease that can affect all levels of society. There are several factors that take part ini caries initiation. Caries risk factors in children are related to age, gender, use of bottles, tooth brushing frequency, the role of the mother, and parental education. The purpose of this studywas to find out factors related to the cause of early childhood caries experienced by preschool children at PAUD Kenanga 17 Kelurahan Penjaringan, Kecamatan Penjaringan, North Jakarta. An observational analytical methods with cross sectional approach was used in this study. Subject in this study consisted of 20 children as a total sample of the population. Data collection was carried out using questionnaires and def-t index was employed for dental examination. Data processing and statistical analysis using chi-square test were applied with a significance value of p less than 0.05. The results showed significant correlation between age (p value 0.001) and gander (p value 0.047) andearly childhood caries.hawever, no correlation was observed betwen the use of bottle (p value 0.909), frequency of tooth brushing (p value 1.00), role of mother (p value 1.00), and parental education (p value 0.798) and early childhood caries.
Knowledge and Attitudes of Students of Faculty of Medicine, YARSI University Towards Hepatitis B Vaccine from the Medical Perspective and Islamic Point of View
Authors: Sahir Asep Zainuddin , Basbeth Ferryal 
Published: March 2021

Background: Hepatitis B is a major cause of morbidity and death, and is still a health problem for many people in the world. Indonesia is one of the countries that has a medium hepatitis B surface antigen (HBsAg) prevalence, which is between 3.0% -18.5%. The main content of a vaccine is a virus or bacteria. In addition to active ingredients, there are adjuvants in the vaccine ingredients. The combination of the main active ingredients (antigens) and adjuvants is more effective than using an antigen vaccine only. In Islam, the vaccination includes preventive treatment measures (wiqayah), therefore the vaccines are subject to legal treatment, with various opinions from halal (permissible) to forbidden. This study aimed to find out the knowledge and attitudes of students of faculty of medicine, YARSI University towards Hepatitis B vaccines viewed from the medical and Islamic perspective. Method: The study used cross sectional research design. The participants of this study were active students of Faculty of Medicine, YARSI University year 2015 by using questionnaire. The total number of students of class 2015 was 250 people. The number of students who met the inclusion criteria was 224 students. Error margin was 5% with a minimum sample estimate of 144 people. Result: As many as 24% of the students was aware that hepatitis B vaccine contains aluminum, formaldehyde. Meanwhile, 72% of the knew that aluminum side effects causes CNS damage. The percentage of students who knew that rejecting the vaccination can be penalized was 27%. While 69% of the students knew that the provision of vaccine does not require informed consent. About 79% of the students understood that technique treatment from prophet era as an alternative to increase immunity in children. Regarding the attitudes towards vaccine programs promoted by the government, 31.2% of the students disagreed. While 33.1% of the students agreed with the provision of vaccines. The majority of the students (70.8%) agreed with obtaining informed consent before the vaccination. Moreover, 58% of the students Were doubtful about education before giving the vaccine. While 58% of the students disagreed that the technique method can be an alternative to substitute vaccines. Conclusion: Although there was a lack of students’ knowldge about aluminum content, Thimerosal and formaldehyde in vaccines, the students know that long term use of Hepatitis B Vaccine which contain Aluminum, Thimerosal and Formaldehyde can cause damage to the central nervous system. Regarding the students’ attitude towards Hepatitis B immunization, the students agree with the immunization program promoted by the government but they agree that informed consent should be taken and do not know about the sanction if they block or reject the immunization program by the government.
The Decision Support System for Product Purchasing
Authors: Kafin Kafin , Galinium Maulahikmah , Erwin Alva 
Published: March 2021

In the development of the technology, the variety of notebook has become diverse. It can be differed by its rice, model, type, and functionality, such as weight, screen size, processor, hard disk, memory (RAM), and graphic card. All of that diversity has become the consideration by the one who looking for a notebook. There has a problem where the buyer is so confused in deciding which notebook that is suitable with their needs. Decision support system is considered as one of the solutions to handle that kind of problem. Fuzzy Tahani Algorithm that uses the relative and qualitative natural language as the user input criteria is believed to be able to help the notebook buyer in making the decision. The result is shown that the decision support system for purchasing multi criteria product such as notebook, based on the user input criteria with the Fuzzy Tahani algorithm, is able to help the user to get the alternative product that can be recommended to them.
Leak in OpenSSL
Authors: Yapri Jason , Hananto Rinkel 
Published: March 2021

The term “hacker” has been spread around the world and has always been considered as a threat when we use the internet. We often hear hackers deface websites’ contents and break into system to steal private and confidential information, such as account’s username and password, credit card numbers and others. This is definitely an unethical behavior of irresponsible people who mostly aims to gain profit. However the term hacker, on the contrary actually originates from an expert computer technicians who tries to access the system to debug and fix security problems of the system.
Nowadays there are dozens of websites out there and some of those websites have low level of security. Hacker can easily break through their system and steal their private confidential data but just because these websites have low level security, that doesn’t mean that it is ethical to break into someone’s system and read their data. It goes the same when someone entering other people’s house because the door was left open by the owner.
As web development grows rapidly, security has become an essential part to make the website more secure and reliable. This is when a group of people decided to make a collaborative project on the implementation of SSL (Secure Socket Layer) and TLS (Transport Layer Security) that is available to be used by everyone. This project is called as OpenSSl and has been used by most of the websites in the internet today. What if this OpenSSL, which has been trusted and implemented by 2/3rd of the websites all around the world can be breached? Definitely it will attract dozens of hackers all around the world to do something unimaginably dangerous.
Italian Tsunami Effects Database (ITED): The First Database of Tsunami Effects Observed Along the Italian Coasts
Authors: Maramai Alessandra , Graziani Laura , Brizuela Beatriz 
Published: March 2021

Traditional tsunami catalogues are conceived as a collection of tsunamis classified by the generating cause, providing a general description of the effects observed for each tsunami. Those catalogues, even if they provide fundamental information, are not suitable for producing an exhaustive picture of the geographical distribution of the tsunami effects. In this paper we introduce the new Italian Tsunami Effects Database (ITED), a collection of evidence documenting the effects along the Italian coasts from historical times to present. The database comes forth the Euro-Mediterranean Tsunami Catalogue (EMTC) and focusses on the effects of tsunamis observed along the Italian coasts providing descriptive and quantitative information for each OP. The information reported in ITED does not only concern the effects produced by Italian tsunamis, but also those effects produced by tsunamis originated outside the Italian territory. ITED contains 318 OPs, related to 73 Italian tsunamis and to four tsunamis which occurred outside Italy. The database can be accessed through a WebApp that displays for each OP the description of effects, quantitative data (run-up, inundation, withdrawal, etc.) and tsunami intensity with the corresponding bibliographic references. The database also provides the tsunami intensity distribution along time (tsunami-history) for each site, allowing the end user to know how a place has been affected by tsunamis over the time. The information contained in ITED makes this database a useful tool to understand how tsunamis have affected the Italian territory and emphasizes the importance of studying the tsunami hazard along the Italian coasts.
Significance of Crooke's Hyaline Change in Nontumorous Corticotrophs of Patients With Cushing Disease
Authors: Akirov Amit , Larouche Vincent , Shimon Ilan , Asa Sylvia L. , Mete Ozgur , Sawka Anna M. , Gentili Fred , Ezzat Shereen 
Published: March 2021

BackgroundGlucocorticoid excess in Cushing disease (CD) leads to negative feedback suppression, resulting in Crooke's hyaline change (CC) of nontumorous pituitary corticotrophs. We aimed to determine the predictive value of CC of nontumorous corticotrophs in CD.MethodsThe retrospective chart review study included patients with clinical, biochemical, radiologic and outcome data and evaluable histopathology specimens from pituitary surgery for CD. The main outcome was remission of CD, defined by clinical features, biochemical testing, and corticosteroid dependency.ResultsOf 144 CD patients, 60 (50 women, mean age 43.6±14) had clinical follow-up, biochemical data and histopathology specimens that included evaluable nontumorous adenohypophysis. Specimens from 50 patients (83.3%) demonstrated CC in nontumorous corticotrophs, and 10 (16.7%) had no CC (including 3 with corticotroph hyperplasia). One patient with CC was lost to follow-up and one without CC had equivocal outcome results. During a mean (SD) follow-up period of 74.9 months (61.0), recurrent or persistent disease was documented in 18 patients (31.0%), while 40 (69.0%) were in remission. In patients with CC, the remission rate was 73.5% (95% CI, 59.7%-83.7%) (36/49), whereas it was 44.4% (95% CI, 18.9%-73.3%) (4/9) in patients with no CC. The combination of serum cortisol &gt;138 nmol/L within a week of surgery coupled with absence of nontumorous CC greatly improved the prediction of recurrent or persistent disease.ConclusionsCC of nontumorous corticotrophs was observed in 83% of patients with CD, and most patients with CC experienced remission. Absence of CC in nontumorous corticotrophs may serve as a predictor of reduced remission in patients with CD.
Comprehensive Analysis of APA Events and Their Association With Tumor Microenvironment in Lung Adenocarcinoma
Authors: Zhang Yuchu , Shen Libing , Shi Qili , Zhao Guofang , Wang Fajiu 
Published: March 2021

BackgroundAlternative polyadenylation (APA) is a pervasive posttranscriptional mechanism regulating gene expression. However, the specific dysregulation of APA events and its potential biological or clinical significance in lung adenocarcinoma (LUAD) remain unclear.MethodsHere, we collected RNA-Seq data from two independent datasets: GSE40419 (n= 146) and The Cancer Genome Atlas (TCGA) LUAD (n= 542). The DaPars algorithm was employed to characterize the APA profiles in tumor and normal samples. Spearman correlation was used to assess the effects of APA regulators on 3′ UTR changes in tumors. The Cox proportional hazard model was used to identify clinically relevant APA events and regulators. We stratified 512 patients with LUAD in the TCGA cohort through consensus clustering based on the expression of APA factors.FindingsWe identified remarkably consistent alternative 3′ UTR isoforms between the two cohorts, most of which were shortened in LUAD. Our analyses further suggested that aberrant usage of proximal polyA sites resulted in escape from miRNA binding, thus increasing gene expression. Notably, we found that the 3′ UTR lengths of the mRNA transcriptome were correlated with the expression levels of APA factors. We further identified that CPSF2 and CPEB3 may serve as key regulators in both datasets. Finally, four LUAD subtypes according to different APA factor expression patterns displayed distinct clinical results and oncogenic features related to tumor microenvironment including immune, metabolic, and hypoxic status.InterpretationOur analyses characterize the APA profiles among patients with LUAD and identify two key regulators for APA events in LUAD, CPSF2 and CPEB3, which could serve as the potential prognostic genes in LUAD.
Detection of Genetic Overlap Between Rheumatoid Arthritis and Systemic Lupus Erythematosus Using GWAS Summary Statistics
Authors: Lu Haojie , Zhang Jinhui , Jiang Zhou , Zhang Meng , Wang Ting , Zhao Huashuo , Zeng Ping 
Published: March 2021

BackgroundClinical and epidemiological studies have suggested systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are comorbidities and common genetic etiologies can partly explain such coexistence. However, shared genetic determinations underlying the two diseases remain largely unknown.MethodsOur analysis relied on summary statistics available from genome-wide association studies of SLE (N= 23,210) and RA (N= 58,284). We first evaluated the genetic correlation between RA and SLE through the linkage disequilibrium score regression (LDSC). Then, we performed a multiple-tissue eQTL (expression quantitative trait loci) weighted integrative analysis for each of the two diseases and aggregated association evidence across these tissues via the recently proposed harmonic meanP-value (HMP) combination strategy, which can produce a single well-calibratedP-value for correlated test statistics. Afterwards, we conducted the pleiotropy-informed association using conjunction conditional FDR (ccFDR) to identify potential pleiotropic genes associated with both RA and SLE.ResultsWe found there existed a significant positive genetic correlation (rg= 0.404,P= 6.01E-10) via LDSC between RA and SLE. Based on the multiple-tissue eQTL weighted integrative analysis and the HMP combination across various tissues, we discovered 14 potential pleiotropic genes by ccFDR, among which four were likely newly novel genes (i.e.,INPP5B,OR5K2,RP11-2C24.5, andCTD-3105H18.4). The SNP effect sizes of these pleiotropic genes were typically positively dependent, with an average correlation of 0.579. Functionally, these genes were implicated in multiple auto-immune relevant pathways such as inositol phosphate metabolic process, membrane and glucagon signaling pathway.ConclusionThis study reveals common genetic components between RA and SLE and provides candidate associated loci for understanding of molecular mechanism underlying the comorbidity of the two diseases.
Clinical Implications of Psychophysical Olfactory Testing: Assessment, Diagnosis, and Treatment Outcome
Authors: Su Baihan , Bleier Benjamin , Wei Yongxiang , Wu Dawei 
Published: March 2021

Purpose of ReviewOlfactory dysfunction dramatically impairs quality of life with a prevalence of 20% in the general adult population. Psychophysical olfactory testing has been widely used to evaluate the ability to smell due to its validated utility and feasibility in clinic. This review summarizes the current literature regarding psychophysical olfactory testing and the clinical relevance of the olfactory testing with different components. Furthermore, the review highlights the diagnosis and treatment value of olfactory subtests in patients with olfactory dysfunction.Recent FindingsWith the accumulation of studies of psychophysical olfactory testing in olfactory disorders, the clinical relevance of olfactory testing with different components is expanding. Different olfactory domains present with distinct olfactory processing and cortical activity. Psychophysical assessment of olfaction with three domains reveals different levels of olfactory processing and might assist with analyzing the pathophysiologic mechanism of the various olfactory disorders. Furthermore, olfactory thresholds provided the largest amount of non-redundant information to the olfactory diagnosis. Sinonasal olfactory dysfunction and non-sinonasal-related olfactory dysfunction are emerging classifications of smell disorders with certain characteristics of olfactory impairment and different responses to the therapy including steroids, sinus surgery, and olfactory training.SummaryThese recent advancements should promote the understanding of psychophysical olfactory testing, the association between individual subcomponents and neurophysiological processes, and pave the way for precision assessment and treatment of the olfactory dysfunction.
Computed Tomography Features of Gastric Cancer Patients With DNA Mismatch Repair Deficiency
Authors: Cao Qian , Lai Sheng-Yuan , Xu Nan , Lu Yang , Chen Shuai , Zhang Xin-Sheng , Li Xiang 
Published: March 2021

ObjectiveTo explore the computed tomography (CT) features of gastric cancer (GC) patients with DNA mismatch repair deficiency (dMMR).Materials and MethodsThis study reviewed the clinical and CT features of GC patients with dMMR, confirmed by the postoperative results, between September 2017 and December 2019. The expression pattern of MMR major proteins (MLH1, MSH2, MSH6, and PMS2) in immunohistochemistry was used to confirm the MMR status in GC tissues. The correlation between pre-treatment CT features and MMR status was statistically analyzed.ResultsA total of 28 patients with GC were diagnosed as dMMR in our study, and 49 patients were MMR-proficient (pMMR). The tumor locations were significantly different between the dMMR and pMMR groups (p = 0.006). The CT tumor thickness, CT long and short diameters of the largest lymph node, and the number of lymph nodes on CT of the dMMR group were significantly different from the pMMR group.ConclusionThe dMMR GC exhibited a lower stomach location, smaller tumor thickness and lymph node diameter, and fewer lymph nodes on CT imaging.
Impact of Postoperative Radiotherapy on Survival of Patients With de novo Stage IV Breast Cancer: A Population-Based Study From the SEER Database
Authors: Zhang Jie , Luo Shiping , Qiu Zhaozhen , Lin Yuxiang , Song Chuangui 
Published: March 2021

Purpose: In our study, we aimed to evaluate the role of postoperative radiotherapy for patents with de novo stage IV breast cancer.Patients and Methods: Patients diagnosed with stage IV breast cancer from 2010 to 2016 were selected from the Surveillance, Epidemiology, and End Result (SEER) database. Those patients who received both chemotherapy and surgery and lived longer than 6 months were divided into radiotherapy and non-radiotherapy groups. Kaplan-Meier analysis and multivariate Cox proportional hazards models were used to estimate the survival outcomes before and after being 1:1 propensity score matched (PSM). Subgroup analyses stratified by age, subtype, status of distant metastasis, and surgery type were also performed.Results: Among 1,935 patients, 52% (1006) underwent radiotherapy while the non-radiotherapy group contained 48% (929). After PSM, a total of 1,520 patients in two groups of 760 patients were enrolled in this analysis. Kaplan-Meier and the multivariate survival analysis demonstrated that the radiotherapy group presented with a better prognosis compared to the non-radiotherapy group (after PSM, BCSS: Hazard Ratio, 0.697; 95% confidence interval, 0.59–0.823; P &lt; 0.001; OS: Hazard Ratio, 0.707; 95% confidence interval, 0.601–0.831; P &lt; 0.001). Further subgroup analyses showed the Luminal subtype (HR+/HER2–), triple-negative breast cancer (TNBC), and bone-only metastasis patients presented with the most promising survival in the radiotherapy group.Conclusions: Postoperative radiotherapy is associated with a significant survival advantages in BCSS and OS. It can be an optimal supplementary treatment for stage IV patients after surgery, especially for Luminal subtype, TNBC, and patients with a low metastatic burden.
Relating Gut Microbiome and Its Modulating Factors to Immunotherapy in Solid Tumors: A Systematic Review
Authors: Huang Chengliang , Li Meizhang , Liu Ben , Zhu Huanbo , Dai Qun , Fan Xianming , Mehta Kathan , Huang Chao , Neupane Prakash , Wang Fen , Sun Weijing , Umar Shahid , Zhong Cuncong , Zhang Jun 
Published: March 2021

Background: Gut microbiome is proved to affect the activity of immunotherapy in certain tumors. However, little is known if there is universal impact on both the treatment response and adverse effects (AEs) of immune checkpoint inhibitors (ICIs) across multiple solid tumors, and whether such impact can be modulated by common gut microbiome modifiers, such as antibiotics and diet.Methods: A systematic search in PubMed followed by stringent manual review were performed to identify clinical cohort studies that evaluated the relevance of gut microbiome to ICIs (response and/or AEs, 12 studies), or association of antibiotics with ICIs (17 studies), or impact of diet on gut microbiome (16 studies). Only original studies published in English before April 1st, 2020 were used. Qualified studies identified in the reference were also included.Results: At the phylum level, patients who had enriched abundance in Firmicutes and Verrucomicrobia almost universally had better response from ICIs, whereas those who were enriched in Proteobacteria universally presented with unfavorable outcome. Mixed correlations were observed for Bacteroidetes in relating to treatment response. Regarding the AEs, Firmicutes correlated to higher incidence whereas Bacteroidetes were clearly associated with less occurrence. Interestingly, across various solid tumors, majority of the studies suggested a negative association of antibiotic use with clinical response from ICIs, especially within 1-2 month prior to the initiation of ICIs. Finally, we observed a significant correlation of plant-based diet in relating to the enrichment of “ICI-favoring” gut microbiome (P = 0.0476).Conclusions: Gut microbiome may serve as a novel modifiable biomarker for both the treatment response and AEs of ICIs across various solid tumors. Further study is needed to understand the underlying mechanism, minimize the negative impact of antibiotics on ICIs, and gain insight regarding the role of diet so that this important lifestyle factor can be harnessed to improve the therapeutic outcomes of cancer immunotherapy partly through its impact on gut microbiome.