bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intermittent Fasting Inhibits High-Fat Diet–Induced Atherosclerosis by Ameliorating Hypercholesterolemia and Reducing Monocyte Chemoattraction
Authors: Chen Yuanli , Su Jiamin , Yan Yali , Zhao Qian , Ma Jialing , Zhu Mengmeng , He Xiaoyu , Zhang Baotong , Xu Hongmei , Yang Xiaoxiao , Duan Yajun , Han Jihong 
Published: September 2021

Atherosclerosis is a major pathology for cardiovascular diseases (CVDs). Clinically, the intermittent fasting (IF) has been observed to reduce the risk of CVDs. However, the effect of IF on the development of atherosclerosis has not been fully elucidated. Herein, we determined the protection of IF against high-fat diet–induced atherosclerosis in pro-atherogenic low-density lipoprotein receptor deficient (LDLR-/-) mice and the potentially involved mechanisms. The LDLR-/- mice were scheduled intermittent fasting cycles of 3-day HFD feeding ad libitum and 1 day fasting, while the mice in the control group were continuously fed HFD. The treatment was lasted for 7 weeks (∼12 cycles) or 14 weeks (∼24 cycles). Associated with the reduced total HFD intake, IF substantially reduced lesions in the en face aorta and aortic root sinus. It also increased plaque stability by increasing the smooth muscle cell (SMC)/collagen content and fibrotic cap thickness while reducing macrophage accumulation and necrotic core areas. Mechanistically, IF reduced serum total and LDL cholesterol levels by inhibiting cholesterol synthesis in the liver. Meanwhile, HFD-induced hepatic lipid accumulation was attenuated by IF. Interestingly, circulating Ly6Chigh monocytes but not T cells and serum c-c motif chemokine ligand 2 levels were significantly reduced by IF. Functionally, adhesion of monocytes to the aortic endothelium was decreased by IF via inhibiting VCAM-1 and ICAM-1 expression. Taken together, our study indicates that IF reduces atherosclerosis in LDLR-/- mice by reducing monocyte chemoattraction/adhesion and ameliorating hypercholesterolemia and suggests its potential application for atherosclerosis treatment.
Uncertainty Quantification of Regional Cardiac Tissue Properties in Arrhythmogenic Cardiomyopathy Using Adaptive Multiple Importance Sampling
Authors: van Osta Nick , Kirkels Feddo P. , van Loon Tim , Koopsen Tijmen , Lyon Aurore , Meiburg Roel , Huberts Wouter , Cramer Maarten J. , Delhaas Tammo , Haugaa Kristina H. , Teske Arco J. , Lumens Joost 
Published: September 2021

Introduction: Computational models of the cardiovascular system are widely used to simulate cardiac (dys)function. Personalization of such models for patient-specific simulation of cardiac function remains challenging. Measurement uncertainty affects accuracy of parameter estimations. In this study, we present a methodology for patient-specific estimation and uncertainty quantification of parameters in the closed-loop CircAdapt model of the human heart and circulation using echocardiographic deformation imaging. Based on patient-specific estimated parameters we aim to reveal the mechanical substrate underlying deformation abnormalities in patients with arrhythmogenic cardiomyopathy (AC).Methods: We used adaptive multiple importance sampling to estimate the posterior distribution of regional myocardial tissue properties. This methodology is implemented in the CircAdapt cardiovascular modeling platform and applied to estimate active and passive tissue properties underlying regional deformation patterns, left ventricular volumes, and right ventricular diameter. First, we tested the accuracy of this method and its inter- and intraobserver variability using nine datasets obtained in AC patients. Second, we tested the trueness of the estimation using nine in silico generated virtual patient datasets representative for various stages of AC. Finally, we applied this method to two longitudinal series of echocardiograms of two pathogenic mutation carriers without established myocardial disease at baseline.Results: Tissue characteristics of virtual patients were accurately estimated with a highest density interval containing the true parameter value of 9% (95% CI [0–79]). Variances of estimated posterior distributions in patient data and virtual data were comparable, supporting the reliability of the patient estimations. Estimations were highly reproducible with an overlap in posterior distributions of 89.9% (95% CI [60.1–95.9]). Clinically measured deformation, ejection fraction, and end-diastolic volume were accurately simulated. In presence of worsening of deformation over time, estimated tissue properties also revealed functional deterioration.Conclusion: This method facilitates patient-specific simulation-based estimation of regional ventricular tissue properties from non-invasive imaging data, taking into account both measurement and model uncertainties. Two proof-of-principle case studies suggested that this cardiac digital twin technology enables quantitative monitoring of AC disease progression in early stages of disease.
A New Routine for Analyzing Brief Symptom Inventory Profiles in Chronic Pain Patients to Evaluate Psychological Comorbidity
Authors: Franke Gabriele Helga , Jagla-Franke Melanie , Küch Dieter , Petrowski Katja 
Published: September 2021

Question: Comorbidity, i.e., additional psychological distress in patients already suffering from chronic somatic diseases (e.g., orthopedic conditions) is of growing importance. The quality of analyzing and interpreting the often used Brief Symptom Inventory (BSI) used with orthopedic patients should improve by employing a new “case definition” of four groups (instead of two) of differentially psychologically distressed patients instead of two groups as before.Methods: Four groups with the different psychological distress definitions of “no,” “mild,” “remarkable,” and “severe” were to be analyzed from a group of 639 orthopedic patients in inpatient rehabilitation clinics. The BSI is transformed into T values (M=50, SD=10). There is “no” distress if no T [two scales] is ≥60 and “mild” distress if T [two scales] and/or T [GSI] is ≥60 and &lt;63. If T [two scales] and/or T [GSI] is ≥63 and &lt;70, it is “remarkable,” and if T [two scales] and/or T [GSI] ≥70, it speaks for “severe” psychological distress.Results: The new tool for analyzing psychological distress based on the T-scores of the BSI resulted in the following four groups: No psychological distress (41.9%): unspecific health-related information stands for a useful intervention. About 13.3% demonstrated low psychological distress: shorter diagnostic interviews and a few more diagnostic examinations led to a low-level outpatient group program to improve health and well-being in a preventive sense; one repeated measurement in 4weeks is advised. Remarkable psychological distress (26%): in-depth exploration using interviews, tests, and questionnaires to choose specific interventions in a single and/or group setting, outpatient or inpatient treatment; repeated measurements and process control. About 18.8% reported severe psychological distress: in-depth exploration led to specific interventions in a single and/or group setting, almost an inpatient setting; immediately crisis intervention and high-frequent process control.Conclusion: The new evaluation strategy of the BSI should improve practice and research; further investigation is necessary.
Cochlear Size Assessment Predicts Scala Tympani Volume and Electrode Insertion Force- Implications in Robotic Assisted Cochlear Implant Surgery
Authors: Dhanasingh Anandhan , Swords Chloe , Bance Manohar , Van Rompaey Vincent , Van de Heyning Paul 
Published: September 2021

Objectives: The primary aim was to measure the volume of the scala tympani (ST) and the length of the straight portion of the cochlear basal turn from micro-computed tomography (μCT) images. The secondary aim was to estimate the electrode insertion force based on cochlear size and insertion speed. Both of these objectives have a direct clinical relevance in robotic assisted cochlear implant (CI) surgery.Methods: The ST was segmented in thirty μCT datasets to create a three-dimensional (3D) model and calculate the ST volume. The diameter (A-value), the width (B-value), and the straight portion of the cochlear basal turn (S-value) were measured from the oblique coronal plane. Electrode insertion force was measured in ST models of two different sizes, by inserting FLEX24 (24 mm) and FLEX28 (28 mm) electrode arrays at five different speeds (0.1, 0.5, 1, 2, and 4 mm/s).Results: The mean A-, B-, and S-values measured from the 30 μCT datasets were 9.0 ± 0.5, 6.7 ± 0.4, and 6.9 mm ± 0.5, respectively. The mean ST volume was 34.2 μl ± 7 (range 23–50 μl). The ST volume increased linearly with an increase in A- and B-values (Pearson's coefficient r = 0.55 and 0.56, respectively). The A-value exhibited linear positive correlation with the B-value and S-value (Pearson's coefficient r = 0.64 and r = 0.66, respectively). In the smaller of the two ST models, insertion forces were higher across the range of insertion speeds during both array insertions, when compared to the upscaled model. Before the maximum electrode insertion depths, a trend toward lower insertion force for lower insertion speed and vice-versa was observed.Conclusion: It is important to determine pre-operative cochlear size as this seems to have an effect upon electrode insertion forces. Higher insertion forces were seen in a smaller sized ST model across two electrode array lengths, as compared to an upscaled larger model. The ST volume, which cannot be visualized on clinical CT, correlates with clinical cochlear parameters. This enabled the creation of an equation capable of predicting ST volume utilizing A- and B-values, thus enabling pre-operative prediction of ST volume.
Quantitative Analysis of Temporal Bone Density and Thickness for Robotic Ear Surgery
Authors: Talon Emile , Visini Miranda , Wagner Franca , Caversaccio Marco , Wimmer Wilhelm 
Published: September 2021

Background and Objective: Quantitative assessment of bone density and thickness in computed-tomography images offers great potential for preoperative planning procedures in robotic ear surgery.Methods: We retrospectively analyzed computed-tomography scans of subjects undergoing cochlear implantation (N = 39). In addition, scans of Thiel-fixated ex-vivo specimens were analyzed (N = 15). To estimate bone mineral density, quantitative computed-tomography data were obtained using a calibration phantom. The temporal bone thickness and cortical bone density were systematically assessed at retroauricular positions using an automated algorithm referenced by an anatomy-based coordinate system. Two indices are proposed to include information of bone density and thickness for the preoperative assessment of safe screw positions (Screw Implantation Safety Index, SISI) and mass distribution (Column Density Index, CODI). Linear mixed-effects models were used to assess the effects of age, gender, ear side and position on bone thickness, cortical bone density and the distribution of the indices.Results: Age, gender, and ear side only had negligible effects on temporal bone thickness and cortical bone density. The average radiodensity of cortical bone was 1,511 Hounsfield units, corresponding to a bone mineral density of 1,145 mg HA/cm3. Temporal bone thickness and cortical bone density depend on the distance from Henle's spine in posterior direction. Moreover, safe screw placement locations can be identified by computation of the SISI distribution. A local maximum in mass distribution was observed posteriorly to the supramastoid crest.Conclusions: We provide quantitative information about temporal bone density and thickness for applications in robotic and computer-assisted ear surgery. The proposed preoperative indices (SISI and CODI) can be applied to patient-specific cases to identify optimal regions with respect to bone density and thickness for safe screw placement and effective implant positioning.
Perancangan Sistem Pengelolaan Keuangan Komite Menggunakan Web Engineering (Studi Kasus : SMK Negeri 1 Gedong Tataan)
Authors: Setiawansyah Setiawansyah , Sulistiani Heni , Sulistiyawati Ari , Hajizah Arsi 
Published: September 2021

Pengelolaan keuangan di sekolah merupakan salah satu kegiatan yang sangat penting, karena setiap kegiatan yang dilakukan disekolah pasti membutuhkan manajemen keuangan. Sistem informasi mengenai pencatatan dan pengolahan data administrasi keuangan komite di sekolah seperti pencatatan penerimaan dan pengeluaran dana yang berasal dari pembayaran Iuran Komite Siswa kedalam suatu database untuk otomatisasi pembuatan laporan-laporan yang di butuhkan, Sehingga bagian keuangan tidak akan mengalami kesulitan dalam mencari data siswa yang belum membayar iuran komite sekolah, juga memudahkan dalam pembuatan laporan-laporan mengenai administrasi keuangan iuran komite di sekolah tersebut. Tahapan-tahapan dalam web engineering yaitu Customer communication, Planning, Modelling, Construction dalam aplikasi sistem pengelolaan keuangan komite sekolah. Hasil pengujian sistem informasi pengelolaan keuangan komite sekolah menggunakan metode web engineering pada SMK Negeri 1 Gedong Tataan menggunakan aplikasi berbasis web yang dibuat dengan bahasa pemrograman PHP dan framework CodeIgniter dan database MySql untuk pengujian fungsionalitas sistem menggunakan black box testing mendapatkan nilai 100% sesuai dengan fungsionalitas sistem, serta hasil pengujian Web Quality 4.0 mendapatkan nilai 87,6% memiliki kriteria Sangat Baik dari pengujian usability
Os fundamentos religiosos do Capitalismo e da Democracia e uma preocupação com a liberdade: um diálogo entre Tocqueville e Weber
Authors: Ferreira Matheus Gomes Mendonça 
Published: September 2021

No campo da Ciência Política, a religião não se consolidou como um fenômeno analiticamente relevante para compreender as instituições políticas e seus atores. Atribuímos a isso o fato de que muitos dos efeitos que partem da religião incidem indiretamente sobre os fenômenos políticos. A partir dessa reflexão, resgatamos o debate weberiano e tocquevilleano sobre o papel religião sobre o capitalismo e a democracia, tendo como essência uma preocupação com a liberdade humana. Conclui-se que, ao passo que em Tocqueville a religião possui algum poder de resguardar a liberdade humana, na leitura weberiana, isso não ocorre, pois ao se desprender de seus fundamentos, a religião se vê impotente diante na nova ordem social, de um novo tipo de dominação, o racional-legal.
Encíclica Laudato Si’ e as reações de católicos e evangélicos ao cuidado com a casa comum
Authors: LOBÃO DE SOUZA MACÁRIO LUÍS FELIPE 
Published: September 2021

Artigo que tem por objetivo destacar como o tema abordado na Encíclica Laudato Si’ – o cuidado com a casa comum – é tratado por católicos e membros de diferentes igrejas cristãs. A partir de uma leitura crítica de diversos artigos, escritos por teólogos – católicos, protestantes e anglicanos –, cientistas da religião e outros acadêmicos, e publicados em três coletâneas (Cuidar da casa comum: chaves de leitura teológicas e pastorais da Laudato Si’; Evangélicos e o Papa: olhares de lideranças evangélicas sobre a Encíclica Laudato Si’, do Papa Francisco; Diálogos no interior da casa comum: recepções interdisciplinares sobre a encíclica Laudato Si’), pode-se concluir que a preservação do planeta Terra – nossa casa comum – é uma preocupação comum a católicos e evangélicos.
Spill Over of Novel Covid-19 Pandemic on Punjab Tourism
Authors: Kaur Ramanpreet , Mittal Manju 
Published: September 2021

The paper purposes to describe the spread of Covid-19 in Punjab, pre Covid-19 period, its effects on Punjab Tourism, and also put forwards a set of recovery measures for tourism sector. The data used is secondary in nature, collected from news broadcasted by several media outlets, various journals, newspapers, articles and official website of Punjab Tourism, Ministry of Tourism, WHO. The study investigated that the outbreak of the global pandemic Covid-19 (Corona Virus Disease -2019) pandemic is an unprecedented shock to the state’s tourism industry. The Punjab Tourism was in a prospering state before Covid-19 struck. With the prolonged country-wide lockdown, global economic downturn and associated disruption of movement of tourists, the Punjab tourism industry is facing an extended period of decline. The study indicates the effects of Covid-19 in Punjab Tourism and also extends the preventive measures to tackle the pandemic. Although, the length of the impact will depend upon the duration and gravity of the health crisis, the duration of the lockdown and the manner in which the situation unfolds once the lockdown is lifted yet the situation can be tackled by adopting the suggestive recovery measures.
Key words: COVID-19 Pandemic; Punjab Tourism; Tourists Arrival; Spill Over; Recovery Measures.
economia moral dos cuidados:
Authors: Sousa Correa Ranna Mirthes 
Published: September 2021

O presente artigo compõe parte da minha pesquisa de doutorado que procura discutir estratégias de acesso a vagas em creche na educação infantil em Porto Alegre/RS a fim de estar atenta às diversas experiências de cuidado articuladas pelas mães e famílias. Nesse contexto, este texto busca refletir como as casas de "cuida-se", casas de mulheres que cuidam de crianças nas comunidades do Campo da Tuca e no Morro da Polícia são um sítio etnográfico possível para refletir sobre uma economia moral do cuidado de crianças que envolvem as relações entre as famílias, o trabalho e os afetos e o estado. Inspirada pela noção de economia moral de Didier Fassin(2014), proponho refletir sobre tais práticas de cuidado como uma economia moral de cuidados que envolve diferentes atores, instituições e significados. Tais apontamentos são relevantes para se discutir como a relação das casas com o estado estrutura dinâmicas locais diversas na capital gaúcha a partir da agência e articulação dessa população.
El derecho humano a la educación en el tratamiento penitenciario basado en la resocialización: una mirada desde la realidad Argentina.
Authors: Lizio Gabriela Soledad , Scarfó Francisco 
Published: September 2021

Resumen
El presente texto, tiene como objetivo poner en conocimiento y concientizar a la sociedad acerca de la educación como derecho de todo habitante en el mundo, así como también dar a conocer los diferentes hechos que se producen en torno a ello dentro de las cárceles, dificultando e imposibilitando la continuidad de los estudios de quienes allí residen; informando, asimismo, la realidad educativa con la que se ingresa y posteriormente se vive en las cárceles argentinas; advirtiendo la importancia de los centros educativos dentro y fuera de los centros penitenciarios para la continuidad de los estudios de los/as detenidos; entendiendo el rol del Estado y el Servicio Penitenciario en términos de control y derechos; las diferentes acciones legales de los/as privados de la libertad para ejercer los mismos, la mirada social ante los derechos y garantías de éstos; el lugar que la educación ocupa en términos de resociabilización y su distinción del tratamiento.
Palabras-clave: cárcel, tratamiento, resocialización, derecho a la educación.
Salud mental y resocialización: tensiones y desafíos
Authors: Bravo Omar Alejandro 
Published: September 2021

Las cárceles latinoamericanas se caracterizan, por elevados grados de hacinamiento y violencia institucional, así como por albergar a una mayoría de sujetos jóvenes provenientes de contextos de pobreza y vulnerabilidad.
Así mismo, el encarcelamiento afecta la salud mental de estas personas, producto de la violencia cotidiana, la falta de privacidad, distancia con la familia y el ocio obligado, siendo el consumo de drogas una manera de aliviar ese sufrimiento.
No obstante, los efectos del encarcelamiento en la salud mental no han sido suficientemente abordados, en parte porque la función de la psicología en estos contextos se ha visto sofocada por la exigencia de contribuir a los procesos de resocialización de la población presa Esta resocialización, cuando no son ofrecidas condiciones de estudio, formación laboral y posibilidades de inserción social futura, se transforma en un imperativo vacío, una ficción necesaria para la continuidad de este tipo de instituciones.
Este texto, a manera de ensayo, intenta mostrar las tensiones y contradicciones entre esos objetivos de resocialización que la cárcel impone y una perspectiva de salud mental que dimensione formas de relación solidarias y amplias, tomando como referencia para esto una experiencia de intervención realizada en la cárcel de Villahermosa de Cali, Colombia.
Qué Pasó con la Sociedad de Ocio?
Authors: Zuzanek Jiri 
Published: September 2021

Resumen: Este texto presenta el libro Veal, A.J. (2019). Whatever Happened to the Leisure Society? London: Routledge, 296 p., exponen los estúdios anteriores relacionado con el tema, realiza um balance del campo de estúdios y hace uma evaluación del libro bajo análisis.
Palabras clave: Ocio; Historia; Cambio Social; Sociedad.
Cooperativismo e Turismo: a pobreza como eixo discursivo da agenda neoliberal
Authors: Korstanje Maximiliano 
Published: September 2021

A teoria do desenvolvimento sem dúvida abriu uma brecha entre os intelectuais, o que se baseia em seus efeitos. Parte da biblioteca ou literatura especializada chama atenção para a dependência de estados pobres em relação às agências internacionais de financiamento tais como o FMI ou o Banco Mundial, enquanto outros destacam os benefícios de desenvolvimento que, associado ao turismo, tirou certas economias emergentes da estagnação econômica. Este artigo explora teoricamente parte das limitações e vantagens da teoria do desenvolvimento aplicada ao turismo e a hospitalidade; e o faz através de uma de suas formas mais concretas, o cooperativismo. Ele resgata o papel da ética como princípio que vai além da lógica instrumental do mercado, fortalecendo a resiliência comunitária a longo prazo. Paradoxalmente, como enfatizaram Comaroff e Comaroff, o cooperativismo ameaça (sob certas circunstâncias) a governabilidade dos Estados-nação, criando o clima para conflitos sociais e políticos. Nos últimos anos, alguns especialistas têm chamado a atenção para as limitações da comoditização da pobreza, eixo central para o cooperativismo.
Palavras-chave: Pobreza; Desenvolvimento; Dependência; Cooperativismo; Turismo Sustentável.
Miniaturisasi antena mikrostrip array 4×1 elemen menggunakan teknik peripheral slits
Authors: Kartika Putri Tiara , Alam Syah , Surjati Indra 
Published: September 2021

Sistem komunikasi WiFi telah banyak digunakan dalam kebutuhan sehari-hari antara lain untuk keperluan koneksi dan jaringan internet. Dalam penelitian ini, dilakukan miniaturisasi dari antena mikrostrip array linier 4×1 elemen yang bekerja pada frekuensi 2,4 GHz. Pereduksian antena dilakukan dengan metode simulasi dengan penambahan peripheral slits. Efek dari penambahan slit pada patch antena dapat menggeser frekuensi kerja antena menjadi lebih besar sehingga untuk mengembalikan antena pada frekuensi kerjanya dilakukan miniaturisasi dimensi patch antena. Dari hasil simulasi dan optimasi, didapatkan hasil desain yang paling optimal adalah antena mikrostrip patch array 4×1 dengan 16 slit. Penambahan jumlah slit menunjukan dimensi antena berhasil direduksi sebesar 20,45% dengan ukuran patch 28 mm x 20 mm. Nilai koefisien refleksi yang didapatkan sebesar -16,31 dB, gain sebesar 6,43 dB, dan VSWR 1,36 pada frekuensi kerja 2,4 GHz. Penelitian ini bermanfaat sebagai usulan disain antena penerima untuk sistem komunikasi WiFi.