bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex-specific associations between type 2 diabetes incidence and exposure to dioxin and dioxin-like pollutants: a meta-analysis
Authors: Gang Noa , Van Allen Kyle , Villeneuve Paul J. , MacDonald Heather , Bruin Jennifer E. 
Published: September 2021

AbstractThe relationship between persistent organic pollutants (POPs), including dioxins and dioxin-like polychlorinated biphenyls (DL-PCBs), and diabetes incidence in adults has been extensively studied. However, significant variability exists in the reported associations both between and within studies. Emerging data from rodent studies suggest that dioxin exposure disrupts glucose homeostasis in a sex-specific manner. Thus, we performed a meta-analysis of relevant epidemiological studies to investigate whether there are sex-specific associations between dioxin or DL-PCB exposure and type 2 diabetes incidence. Articles were organized into the following subcategories: data stratified by sex (16%), unstratified data (56%), and data from only 1 sex (16% male, 12% female). We also considered whether exposure occurred either abruptly at high levels through a contamination event (“disaster exposure”) or chronically at background levels (“non-disaster exposure”). Only 8 studies compared associations between dioxin/DL-PCB exposure and diabetes risk in males versus females within the same population. When all sex-stratified or single sex studies were considered in the meta-analysis, the summary odds ratio (OR) for increased diabetes risk was similar between females and males (1.78 and 1.95, respectively) when comparing exposed to reference populations, suggesting that this relationship is not sex-specific. However, when we considered disaster-exposed populations separately, the association differed substantially between sexes, with females showing a much higher OR than males (2.86 and 1.59, respectively). Moreover, the association between dioxin/DL-PCB exposure and diabetes was stronger for females than males in disaster-exposed populations. In contrast, both sexes had significantly increased ORs in non-disaster exposure populations and the OR for females was lower than males (1.40 and 2.02, respectively). Our review emphasizes the importance of considering sex differences, as well as the mode of pollutant exposure, when exploring the relationship between pollutant exposure and diabetes in epidemiological studies.
Fc-gamma receptor expression and cytokine response to intravenous human immunoglobulin in mothers and neonates
Authors: Vazquez-Rodriguez Stephania , Arriaga-Pizano Lourdes A. , Mancilla-Herrera Ismael , Prieto-Chávez Jessica , Arizmendi-Villanueva Roberto , Flisser Ana , García-Latorre Ethel , Cérbulo-Vázquez Arturo 
Published: September 2021

AbstractObjectiveThe use of intravenous human immunoglobulin (IVIg) as adjuvant therapy for sepsis has been shown efficacious in adults, but its use in pregnant women and newborns is controversial. Fc gamma receptors (FcγRs) support the ability of IVIg to stimulate the synthesis of inflammatory mediators and promote phagocytosis by leukocytes, however, the FcγRs expression is differential between adults and neonates. We aimed to explore the effect of IVIg in monocytes and neutrophils from mother and neonates in whole blood cultures.Study designWhole blood from adults, maternal, and neonates were incubated with LPS and/or IVIg. After 0, 24, and 48 hours, we measured the expression of FcγRs (CD16, CD32, and CD64) and bacterial phagocytosis by monocytes and neutrophils. Also, the concentration of pro-inflammatory cytokines/chemokines was determined.ResultsFcγRs expression is quite similar among groups, and the LPS or IVIg challenge did not change the FcγRs expression on monocytes and neutrophils. Also, the LPS or IVIg challenge did not modify phagocytosis capacity in any group. However, IVIg induces a higher IL-8 response in neonates than in adults.ConclusionOur results suggest that the IL-8 response to IVIg in whole blood from neonates is not dependent on differential FcγR expression.Key messagesIVIg challenge in neonates or adults does not induce FcγR change expression on monocytes or neutrophilsIVIg induces higher IL-8 response in neonates than in adults
Map-less long-term localization in complex industrial environments
Authors: Liu Zhe , Qiao Zhijian , Suo Chuanzhe , Liu Yingtian , Jin Kefan 
Published: September 2021

Purpose
This paper aims to study the localization problem for autonomous industrial vehicles in the complex industrial environments. Aiming for practical applications, the pursuit is to build a map-less localization system which can be used in the presence of dynamic obstacles, short-term and long-term environment changes.

Design/methodology/approach
The proposed system contains four main modules, including long-term place graph updating, global localization and re-localization, location tracking and pose registration. The first two modules fully exploit the deep-learning based three-dimensional point cloud learning techniques to achieve the map-less global localization task in large-scale environment. The location tracking module implements the particle filter framework with a newly designed perception model to track the vehicle location during movements. Finally, the pose registration module uses visual information to exclude the influence of dynamic obstacles and short-term changes and further introduces point cloud registration network to estimate the accurate vehicle pose.

Findings
Comprehensive experiments in real industrial environments demonstrate the effectiveness, robustness and practical applicability of the map-less localization approach.

Practical implications
This paper provides comprehensive experiments in real industrial environments.

Originality/value
The system can be used in the practical automated industrial vehicles for long-term localization tasks. The dynamic objects, short-/long-term environment changes and hardware limitations of industrial vehicles are all considered in the system design. Thus, this work moves a big step toward achieving real implementations of the autonomous localization in practical industrial scenarios.
Characterisation and comparison of unsteady actuators: a fluidic oscillator and a sweeping jet
Authors: Serrar Abderrahim , El Khlifi Mohamed , Kourta Azeddine 
Published: September 2021

Purpose
The purpose of this study is to compare two unsteady actuators: an oscillator and a sweeping jet. Both actuators can produce an oscillating jet of different amplitudes and frequencies without any moving parts, making them an attractive actuator concept. The Coanda effect phenomenon can explain the operating principles of these two unsteady actuators.

Design/methodology/approach
A numerical study was conducted to compare the amplitudes and frequencies of fluidic and sweeping jet (SJ) oscillators to obtain an efficient actuator to control separated flows at high Reynolds numbers. For this goal, two-dimensional unsteady Reynolds-averaged Navier-Stokes simulations were carried out using computational fluid dynamics (CFD) fluent code to evaluate the actuator performances. The discrete fast Fourier transform method determined the oscillation frequencies.

Findings
The oscillation frequencies gradually increase as the inlet pressure increases. The characteristics and dimensions of the vortices produced in the mixing chamber and feedback loops vary overtime when the injected fluid is swept sideways. The frequencies supplied by the SJ are stronger than those obtained by the fluidic oscillator, which may contribute to improving the aerodynamic performance at a lower power supply cost.

Originality/value
The existence of the splitter in the fluidic oscillator led to the production of separate pulses, which would be useful in various industrial applications, including active control of combustion and mixing processes while other applications such as flow separation control require SJs. With the latter actuator higher and interesting frequencies can be obtained, leading to efficient flow control.
A multiphase acceptance sampling model by attributes to investigate the production interruptions in batch production within tobacco industry
Authors: Yüksel Damla , Kazancoglu Yigit , Sarma P.R.S 
Published: September 2021

PurposeThis paper aims to create a new decision-making procedure that uses “Lot-by-Lot Acceptance Sampling Plan by Attributes” methodology in the production processes when any production interruption is observed in tobacco industry, which is a significant example of batch production.Design/methodology/approachBased on the fish bone diagram, the reasons of the production interruptions are categorized, then Lot-by-Lot Acceptance Sampling Plan by Attributes is studied to overcome the reasons of the production interruptions. Furthermore, managerial aspects of decision making are not ignored and hence, acceptance sampling models are determined by an Analytical Hierarchy Process (AHP) among the alternative acceptance sampling models.FindingsA three-phased acceptance sampling model is generated for determination of the reasons of production interruptions. Hence, the necessary actions are provided according to the results of the proposed acceptance sampling model. Initially, 729 alternative acceptance sampling models are found and 38 of them are chosen by relaxation. Then, five acceptance sampling models are determined by AHP.Practical implicationsThe current experience dependent decision mechanism is suggested to be replaced by the proposed acceptance sampling model which is based on both statistical and managerial decision-making procedure.Originality/valueAcceptance sampling plans are considered as a decision-making procedure for various cases in production processes. However, to the best of our knowledge Lot-by-Lot Acceptance Sampling Plan by Attributes has not been considered as a decision-making procedure for batch production when any production interruption is investigated.
Predicting consumers' intentions to purchase eco-friendly athletic wear in a moderated model of individual green values and gender
Authors: Channa Nisar Ahmed , Tariq Beenish , Samo Altaf Hussain , Ghumro Niaz Hussain , Qureshi Naveed Akhtar 
Published: September 2021

PurposeUsing three theoretical lenses − organismic integration theory (OIT), theory of values-belief-norm (VBN) and gender schema theory (GST) − this study aims to examine the effect of environmental factors (environmental attitude, environmental concerns, perceived environmental responsibility and peer influence) on consumers' intentions to purchase eco-friendly athletic wear.Design/methodology/approachA sample of n = 380 Pakistani consumers was used to test hypothesized relationships. Data were analyzed through the partial least square structural equation modeling (PLS-SEM) technique using SmartPLS version 3.3.3.FindingsFindings suggest that environmental attitude, environmental concerns, perceived environmental responsibility and peer influence are positively associated with green purchase behavior. The moderating effects of individual green values were found statistically significant between peer influence and green purchase behavior. The data further revealed that the effect of environmental attitude, environmental concerns, peer influence and perceived environmental responsibility on green purchase behavior varies across the gender.Originality/valueThis research is one of the first attempts to explore the effect of environmental motivational factors on consumers' intentions to purchase eco-friendly athletic wear using theories of OIT, VBN and GST. This study employs advanced analytical methods to perform multi-group analysis and establish the predictive relevance of the model, using PLS-SEM in sports management and marketing context.
Which formula for corporate risk-taking around the world? Exploring happiness as the “black box”
Authors: Tran Thao Phuong , Le Anh-Tuan 
Published: September 2021

PurposeThis paper examines how the degree of happiness affects corporate risk-taking and the moderating influence of family ownership of firms on this relationship.Design/methodology/approachThe authors use an international sample of 17,654 firm-year observations from 24 countries around the world from 2008 to 2016.FindingsUsing the happiness index from the World Happiness Report developed by the United Nations Sustainable Development Solutions Network, the authors show that a country's overall happiness is negatively correlated with risk-taking behavior by firms. The findings are robust to an alternative measure of risk-taking by firms. Further analyses document that the negative influence of happiness on firm risk-taking is more pronounced for family-owned firms.Practical implicationsThe paper is consistent with the notion that happier people are likely to be more risk-averse in making financial decisions, which, in turn, reduces corporate risk-taking.Originality/valueThis study contributes to the broad literature on the determinants of corporate risk-taking and the growing literature on the role of sentiment on investment decisions. The authors contribute to the current debate about family-owned firms by demonstrating that the presence of family trust strengthens the negative influence of happiness on corporate risk-taking, a topic that has been unexplored in previous studies.
Hotel revenue management forecasting accuracy: the hidden impact of booking windows
Authors: Webb Timothy , Schwartz Zvi , Xiang Zheng , Altin Mehmet 
Published: September 2021

PurposeThe pace of booking is a critical element in the accuracy of revenue management (RM) systems. Anecdotal evidence suggests that booking windows exhibit persistent shifts due to a variety of macro and micro factors. The article outlines several causes and tests the impact of the shifts on forecasting accuracy.Design/methodology/approachA novel methodological approach is utilized to empirically shift hotel reservation windows into smaller increments. Forecasts are then estimated and tested on the incremental shifts with popular RM techniques characteristic of advance booking data. A random effects model assesses the impact of the shifts on forecast accuracy.FindingsThe results show that shifts in booking behavior can cause the accuracy of forecasting models to deteriorate. The findings stress the importance of considering these shifts in model estimation and evaluation.Practical implicationsThe results demonstrate that changes in booking behavior can be detrimental to the accuracy of RM forecasting algorithms. It is recommended that revenue managers monitor booking window shifts when forecasting with advanced booking data.Originality/valueThis study is the first to systematically assess the impact of booking window shifts on forecasting accuracy. The demonstrated approach can be implemented in future research to assess model accuracy as booking behavior changes.
High involvement work practices often lead to burnout, but thanks to humble leadership
Authors: Afshan Gul , Kashif Muhammad , Khanum Firdous , Khuhro Mansoor Ahmed , Akram Umair 
Published: September 2021

PurposeBased on the conservation of resources theory, this study aims to investigate high involvement work practices (HIWP) as an antecedent to burnout with a mediating role of perceived work–family (WF) imbalance. Moreover, this study examines whether humble leadership moderates the relationship between HIWP and WF imbalance.Design/methodology/approachUsing a time-lagged survey approach, data are collected from 200 employees working in the Indian services sector organizations.FindingsThe findings demonstrate that HIWP has a direct negative effect on burnout and an indirect effect via WF imbalance. Also, humble leadership moderates the relationship between HIWP and WF imbalance.Originality/valueBy studying the pessimistic view of HIWP in the Indian context, this study contributes to the scant studies available on its effect on burnout in collectivistic societies. Furthermore, humble leadership's moderating role in the relationship between HIWP and WF imbalance is unique to this study.
Tolerability and efficacy of IMpower133 regimen modified for dialysis patients with extensive‐stage small cell lung cancer: Two case reports
Authors: Watari Naokazu , Yamaguchi Kakuhiro , Masuda Takeshi , Ito Noriaki , Sakamoto Shinjiro , Horimasu Yasushi , Miyamoto Shintaro , Nakashima Taku , Iwamoto Hiroshi , Fujitaka Kazunori , Hamada Hironobu , Hattori Noboru 
Published: September 2021

AbstractThe IMpower133 regimen, composed of atezolizumab/etoposide (VP‐16)/carboplatin (CBDCA), is the standard first‐line treatment for extensive‐stage small cell lung cancer (ES‐SCLC). However, the safety and efficacy of triplet therapy in patients receiving dialysis have not been sufficiently evaluated. Here, we report two cases of dialysis patients with ES‐SCLC who received the modified IMpower133 regimen. Patient 1 was a 69‐year‐old man, and patient 2 was a 73‐year‐old man who received dialysis because of end‐stage renal failure caused by diabetic nephropathy. Both patients received a modified IMpower133 regimen in the following order: atezolizumab (1200 mg/body) on day 1, VP‐16 (50 mg/m2) on days 1 and 3, and CBDCA (300 mg/m2) on day 1. Four hours of dialysis was performed 1 hour after completing the administration of CBDCA on Day 1 and 2 hours after completing the administration of VP‐16 on Day 3. Both patients achieved a partial response and received atezolizumab maintenance therapy after four cycles of triplet therapy without uncontrollable adverse events. By modifying the dosage, the order of drugs, and the timing of dialysis, the IMpower133 regimen may be tolerable and effective for patients receiving dialysis.
Using Mendelian randomization to explore the gateway hypothesis: possible causal effects of smoking initiation and alcohol consumption on substance use outcomes
Authors: Reed Zoe E. , Wootton Robyn E. , Munafò Marcus R. 
Published: September 2021

AbstractBackground and AimsInitial use of drugs such as tobacco and alcohol may lead to subsequent more problematic drug use—the ‘gateway’ hypothesis. However, observed associations may be due to a shared underlying risk factor, such as trait impulsivity. We used bidirectional Mendelian randomization (MR) to test the gateway hypothesis.DesignOur main method was inverse‐variance weighted (IVW) MR, with other methods included as sensitivity analyses (where consistent results across methods would raise confidence in our primary results). MR is a genetic instrumental variable approach used to support stronger causal inference in observational studies.Setting and participantsGenome‐wide association summary data among European ancestry individuals for smoking initiation, alcoholic drinks per week, cannabis use and dependence, cocaine and opioid dependence (n = 1749–1 232 091).MeasurementsGenetic variants for exposure.FindingsWe found evidence of causal effects from smoking initiation to increased drinks per week [(IVW): β = 0.06; 95% confidence interval (CI) = 0.03–0.09; P = 9.44 × 10−06], cannabis use [IVW: odds ratio (OR) = 1.34; 95% CI = 1.24–1.44; P = 1.95 × 10−14] and cannabis dependence (IVW: OR = 1.68; 95% CI = 1.12–2.51; P = 0.01). We also found evidence of an effect of cannabis use on the increased likelihood of smoking initiation (IVW: OR = 1.39; 95% CI = 1.08–1.80; P = 0.01). We did not find evidence of an effect of drinks per week on other substance use outcomes, except weak evidence of an effect on cannabis use (IVW: OR = 0.55; 95% CI = 0.16–1.93; P‐value = 0.35). We found weak evidence of an effect of opioid dependence on increased drinks per week (IVW: β = 0.002; 95% CI = 0.0005–0.003; P = 8.61 × 10−03).ConclusionsBidirectional Mendelian randomization testing of the gateway hypothesis reveals that smoking initiation may lead to increased alcohol consumption, cannabis use and cannabis dependence. Cannabis use may also lead to smoking initiation and opioid dependence to alcohol consumption. However, given that tobacco and alcohol use typically begin before other drug use, these results may reflect a shared risk factor or a bidirectional effect for cannabis use and opioid dependence.
Bud structure and development in trees of a neotropical savanna differing by leaf persistence
Authors: Melo Nayara Magry Jesus , Prado Carlos Henrique Britto de Assis , Branco Denilson Rodrigo Vieira , Souza João Paulo 
Published: September 2021

AbstractThe climatic seasonality affects markedly plant organs' development in the neotropical savannas. Essential understandings about bud structure and its development in deciduous, semi‐deciduous and evergreen trees are unknown in Cerrado vegetation, the largest neotropical savanna. We aimed to determine the bud development, structure and the relationship between budburst and dry and wet seasons for 15 tree species distributed in leaf phenological groups. We labelled five buds in each of the five adult individuals in tree species of each phenological group at the dry season's peak in July 2016. The labelled buds were monitored every week since their opening up to branch development and leaf production in April 2017. Another group of buds was collected at the dry–wet season transition to determine the bud structure. Deciduous tree species showed preformed leaves in buds, the evergreen trees had neoformed leaves, and semi‐deciduous trees had buds with preformed and neoformed leaves. Cataphylls were protecting the buds in all deciduous trees and the semi‐deciduous species Eriotheca gracilipes. Budburst in the deciduous species and semi‐deciduous except for Guapira noxia and Xylopia aromatica occurred at the dry season's peak. In the evergreen trees, buds developed only after the wet season start. While deciduous and evergreen tree species presented different bud structures and development, the semi‐deciduous trees shared the bud traits with phenological groups. We captured distinct growth strategies in groups of trees according to leaf persistence and bud structural and developmental traits.
The alcohol marker phosphatidylethanol is closely related to AST, GGT, ferritin and HDL‐C
Authors: Høiseth Gudrun , Hilberg Thor , Trydal Torleif , Husa Asgeir , Vindenes Vigdis , Bogstrand Stig Tore 
Published: September 2021

AbstractBackgroundThe aim of this study was to evaluate the quantitative relation between common clinical chemical analyses and ethanol use, measured by a combination of the two alcohol markers phosphatidylethanol (PEth) and carbohydrate‐deficient transferrin (CDT).MethodsResults of PEth and CDT in whole blood and serum, respectively, were included, together with information on 10 different commonly measured clinical chemical analytes, as well as age and sex. PEth was analysed by UPC2‐MS/MS and CDT was measured by capillary electrophoresis.ResultsSamples from 4873 patients were included. The strongest relation to alcohol consumption as measured by PEth, when correcting for age and sex, was found for HDL‐C (standardized β = 0.472, p < 0.001), AST (standardized β = 0.372, p < 0.001), ferritin (standardized β = 0.332, p < 0.001) and GGT (standardized β = 0.325, p < 0.001). The relation to PEth was weak for total cholesterol, TG and ALP. No relation was found for Hb and LDL‐C.ConclusionsWhen using PEth as a marker for alcohol consumption, this study demonstrated the quantitative relation to commonly used test as AST or GGT, but also an important relation to ferritin or HDL‐C. In clinical practice, elevated levels of these clinical chemical analytes should initiate further work‐up on possibly harmful alcohol use.