bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: Compound Heterozygous Variants of SLC13A3 Identified in a Chinese Patient With Acute Reversible Leukoencephalopathy and α-Ketoglutarate Accumulation
Authors: Kang Qingyun , Yang Liming , Liao Hongmei , Yang Sai , Yang Haiyang , Ning Zeshu , Liao Caishi , Wu Liwen 
Published: December 2021

Background:SLC13A3 gene encodes the Na+/dicarboxylate cotransporter 3 (NaDC3), which locates on the plasma membrane and is mainly expressed in kidney, astrocytes and the choroid plexus. It imports four to six carbon dicarboxylates together with three Na+ ions into the cytosol. Nowadays, pathogenic variants of SLC13A3 gene were found to cause acute reversible leukoencephalopathy and α-ketoglutarate accumulation (ARLIAK) in patients. Here, we report two novel SLC13A3 variants c.185C&gt;T (p.T62M) and c.331C&gt;T (p.R111*) identified in a Chinese patient with ARLIAK.Case Presentation: The patient was a Chinese girl aged 13 years and 7 months old, who had acute, recurrent neurological deterioration during two febrile episodes. She presented with reversible leukoencephalopathy and increased urinary excretion of α-ketoglutarate. Genetic studies revealed compound heterozygous variants (c.185C&gt;T, p.T62M, and c.331C&gt;T, p.R111*) in SLC13A3, which had not been reported previously.Conclusions: These findings expand the variant spectrum of SLC13A3, providing the basis for the further study of this rare disease.
Cost-Utility Analysis of the Integrated Care Models for the Management of Hypertension Patients: A Quasi-Experiment in Southwest Rural China
Authors: Ke Xiatong , Zhang Liang , Tang Wenxi 
Published: December 2021

Background: Hypertension has become the second-leading risk factor for death worldwide. However, the fragmented three-level “county–township–village” medical and healthcare system in rural China cannot provide continuous, coordinated, and comprehensive health care for patients with hypertension, as a result of which rural China has a low rate of hypertension control. This study aimed to explore the costs and benefits of an integrated care model using three intervention modes—multidisciplinary teams (MDT), multi-institutional pathway (MIP), and system global budget and performance-based payments (SGB-P4P)—for hypertension management in rural China.Methods: A Markov model with 1-year per cycle was adopted to simulate the lifetime medical costs and quality-adjusted life-years (QALYs) for patients. The interventions included Option 1 (MDT + MIP), Option 2 (MDT + MIP + SGB–P4P), and the Usual practice (usual care). We used the incremental cost-effectiveness ratio (ICER), net monetary benefit (NMB), and net health benefit (NHB) to make economic decisions and a 5% discount rate. One-way and probability sensitivity analyses were performed to test model robustness. Data on the blood pressure control rate, transition probability, utility, annual treatment costs, and project costs were from the community intervention trial (CMB-OC) project.Results: Compared with the Usual practice, Option 1 yielded an additional 0.068 QALYs and an additional cost of $229.99, resulting in an ICER of $3,373.75/QALY, the NMB was –$120.97, and the NHB was −0.076 QALYs. Compared with the Usual practice, Option 2 yielded an additional 0.545 QALYs, and the cost decreased by $2,007.31, yielding an ICER of –$3,680.72/QALY. The NMB was $2,879.42, and the NHB was 1.801 QALYs. Compared with Option 1, Option 2 yielded an additional 0.477 QALYs, and the cost decreased by $2,237.30, so the ICER was –$4,688.50/QALY, the NMB was $3,000.40, and the NHB was 1.876 QALYs. The one-way sensitivity analysis showed that the most sensitive factors in the model were treatment cost of ESRD, human cost, and discount rate. The probability sensitivity analysis showed that when willingness to pay was $1,599.16/QALY, the cost-effectiveness probability of Option 1, Option 2, and the Usual practice was 0.008, 0.813, and 0.179, respectively.Conclusions: The integrated care model with performance-based prepaid payments was the most beneficial intervention, whereas the general integrated care model (MDT + MIP) was not cost-effective. The integrated care model (MDT + MIP + SGB-P4P) was suggested for use in the community management of hypertension in rural China as a continuous, patient-centered care system to improve the efficiency of hypertension management.
Optimizing Evaluation of Older Adults With Vision and/or Hearing Loss Using the interRAI Community Health Assessment and Deafblind Supplement
Authors: Urqueta Alfaro Andrea , McGraw Cathy , Guthrie Dawn M. , Wittich Walter 
Published: December 2021

Purpose: Service providers must identify and assess older adults who have concurrent vision and hearing loss, or dual sensory impairment (DSI). An assessment tool suitable for this purpose is the interRAI Community Health Assessment (CHA) and its Deafblind Supplement. This study's goal was to explore this assessment's administration process and to generate suggestions for assessors to help them optimize data collection.Methods: A social worker with experience working with adults who have sensory loss, who was also naïve to the interRAI CHA, administered the assessment with 200 older adults (65+) who had visual and/or hearing loss. The assessor evaluated the utility of the instrument for clinical purposes, focusing on sections relevant to identifying/characterizing adults with DSI.Results: Suggestions include the recommendation to ask additional questions regarding the person's functional abilities. This will help assessors deepen their understanding of the person's sensory status. Recommendations are also provided regarding sensory impairments and rehabilitation, in a general sense, to help assessors administer the interRAI CHA.Conclusions: Suggestions will help assessors to deepen their knowledge about sensory loss and comprehensively understand the assessment's questions, thereby allowing them to optimize the assessment process and increase their awareness of sensory loss in older adults.
Exploring Central Vascular Anatomy With Axial Computed Tomography During Surgery for Sigmoid Colon and Rectal Cancer: New Insights Into the Anatomical Relationship Between the Inferior Mesenteric Artery and the Duodenum
Authors: Cheng Zhiqiang , Ren Pengfei , Wang Xiaoyan , Wang Kexin , Yan Zhibo , Bi Dongsong , Wang Yanlei , Dai Yong , Zhang Xiang 
Published: December 2021

Background: In some individuals, the inferior mesenteric artery (IMA) originates from the aorta above the lower edge of the duodenum. This anatomical feature has rarely been reported but may be important in guiding central vascular ligation and lymph node dissection in colorectal surgery. This retrospective study aimed to explore the anatomical relationship between the IMA and the duodenum and evaluate its potential impact on the efficacy of D3 lymph node dissection.Methods: A total of 439 patients undergoing laparoscopic colorectal surgery at the Department of General Surgery, Qilu Hospital of Shandong University, were retrospectively enrolled. Clinical data from axial computed tomography (CT) scans were collected and analysed.Results: In 27.69% of patients, the IMA originated at or above the lower edge of the duodenum (median distance: −8 mm). These patients were characterised by a shorter superior mesenteric artery to aortic bifurcation distance, a superiorly located IMA origin, and a greater distance between the IMA and both the left colic artery and the inferior mesenteric vein. The number of harvested lymph nodes was not significantly associated with the distance between the IMA and the duodenum (P = 0.858).Conclusions: Preoperative axial CT scans can provide a great deal of information regarding central vascular anatomy in the context of sigmoid colon and rectal cancer surgery. Nearly one-third of patients have the IMA originating at or above the duodenum. Whether this anatomical feature affects D3 lymph node dissection warrants further investigation.
Inhibition of the Growth and Development of Sclerotinia sclerotiorum (Lib.) De Bary by Combining Azoxystrobin, Penicillium chrysogenum VKM F-4876d, and Bacillus Strains
Authors: Yaderets Vera V. , Karpova Nataliya V. , Glagoleva Elena V. , Ovchinnikov Alexander I. , Petrova Kseniya S. , Dzhavakhiya Vakhtang V. 
Published: December 2021

Sclerotinia sclerotiorum (Lib.) de Bary is a plant pathogen with a wide host range, which causes significant yield and storage losses of edible roots and other plant products. Due to its ability to sclerotia formation, the efficient control of this pathogen is complicated. The study of five Bacillus strains (B. subtilis VKM B-3154D, VKM B-3155D, VKM B-3505D, VKM B-2998D, and B. amyloliquefaciens VKM B-3153D) showed their ability to produce polyene antibiotics suppressing the growth and development of plant pathogenic fungi. The maximum concentration of polyene compounds was revealed for B. subtilis VKM B-2998D. A high in vitro antifungal activity of a dry mycelium biomass (DMP) of Penicillium chrysogenum VKM F-4876D, B. subtilis VKM B-2998D, and their combination has been demonstrated in relation to S. sclerotiorum. A combined application of DMP (0.3 g/L) and azoxystrobin at low dosage (2.5 mg/L) showed a high suppressing activity towards S. sclerotiorum (100% growth inhibition) including inhibition of a sclerotia formation that may be useful for the development of efficient methods of crop protection against this plant pathogen. A high performance liquid chromatography (HPLC) analysis of DMP revealed the presence of mevastatin suggesting the mechanism of the DMP antifungal activity is based on the blocking of the ergosterol (the main component of fungal cell walls) biosynthesis. The results of the study provide a prerequisite to the development of biopreparations to control S. sclerotiorum, whose use may provide a reduction of concentrations of fungicides used in agriculture and the corresponding reduction of their negative xenobiotic impact on the environment and recovery of the ecological balance in the soil.
Analytical Expressions for Ising Models on High Dimensional Lattices
Authors: Kryzhanovsky Boris , Litinskii Leonid , Egorov Vladislav 
Published: December 2021

We use an m-vicinity method to examine Ising models on hypercube lattices of high dimensions d≥3. This method is applicable for both short-range and long-range interactions. We introduce a small parameter, which determines whether the method can be used when calculating the free energy. When we account for interaction with the nearest neighbors only, the value of this parameter depends on the dimension of the lattice d. We obtain an expression for the critical temperature in terms of the interaction constants that is in a good agreement with the results of computer simulations. For d=5,6,7, our theoretical estimates match the numerical results both qualitatively and quantitatively. For d=3,4, our method is sufficiently accurate for the calculation of the critical temperatures; however, it predicts a finite jump of the heat capacity at the critical point. In the case of the three-dimensional lattice (d=3), this contradicts the commonly accepted ideas of the type of the singularity at the critical point. For the four-dimensional lattice (d=4), the character of the singularity is under current discussion. For the dimensions d=1, 2 the m-vicinity method is not applicable.
Understanding Bunker Architecture Heritage as a Climate Action Tool: Plan Barron in Lisbon as a “Milieu” and as “Common Good” When Dealing with the Rise of the Water Levels
Authors: Pais Maria Rita , Hoffmann Katiuska , Campos Sandra 
Published: December 2021

Abandoned on the coast as skeletons, bunkers are the last theatrical gesture in the history of Western military architecture (Virilio, 1975). Technically obsolete, this military territory has fallen into extinction and is now generally forgotten. We present the Plan Barron of Defense of Lisbon and Setubal case study, a mid-twentieth-century set of bunkers, recently declassified, as a case study to discuss the future of this heritage facing the climate crisis. Can oblivious historical war heritage be an opportunity to fight climate emergencies? We present four theoretical concepts to fundament this environmental positioning: (i) Heritage Management and Climate Governance, (ii) Techno-aesthetic (Simondon, 1992): panopticon territorial cluster; (iii) Military: camouflage as design, and (iv) Civil: inheritance as future potential. The results allow us to look at military architecture in the form of a bunker, as a set of territorial, architectonic, cultural, and social interests. We demonstrate that the counterpoint of its invisibility is a singular naturalized “milieu”, a place where the memory of war can be transformed as a buffer zone that combines characteristics of climate and coastal resilience with cultural and social interest as a “common good”.
Evaluation of the idiopathic scoliosis of varying severity treatment effectiveness with transpedicular systems
Authors: Zeynalov Yu. L. 
Published: December 2021

Introduction Significant success has been achieved in the development of new methods of treatment and rehabilitation of patients with idiopathic scoliosis, however, in many aspects of this problem there is no unambiguous approach to the choice of a correction method, assessment of treatment results.Objective To study the results of treatment of patients with idiopathic scoliosis according to X-ray and MSCT data, as well as according to the questionnaire – the SRS-30, depending on the degrees of the deformity, the type of scoliosis.Material and methods The study is retrospective, single center. Evidence level – IV. In 300 patients with idiopathic scoliosis of varying severity at the age from 10 to 50 years, the immediate and long-term results of elimination of spinal deformity by the method of internal transpedicular fixation were studied. In the study we used polypositional radiography, multislice computed tomography (MSCT) and questionnaire SRS-30.Results In patients with spinal deformity up to 60 ° a year after surgery, no loss of correction was found. After elimination of the deformity at 60–90 °, loss of correction up to 2 ° was observed in 3.6% of patients. In patients with deformity greater than 90 °, the average postoperative progression of scoliotic deformity was 3.5 ± 0.7 °. When examining patients after 2–5 years, there was no loss of correction in the group with initial spinal deformity up to 60 ° and in the group from 60–90 °. In patients with deformity greater than 90 °, the postoperative progression of scoliotic deformity in persons over 25 years old was 4.5 ± 0.6 °, which is associated with degenerative changes in the spine.Conclusion The study of immediate and long-term results showed that 1 year after treatment, 94% of patients rated the treatment result as excellent and good, in 6% – as satisfactory. All patients noted a positive effect of the cosmetic and functional results of treatment, while 56% believed that they looked “better” than before surgery (4 points), 44% rated the effect at 5 points and noted that they looked “much better”. Long-term results were studied in 50 patients 10 years after surgery.
Integrated approach to reducing drinking water losses in the distribution networks in the city of Sebastopol
Authors: Степакин А.В. , Перегуда А.Н. , Зайцева С.Г. , Горбачев Д.А. , Сопыряев М.Н. 
Published: December 2021

Природный дефицит водных ресурсов в сочетании с высокой степенью износа систем водоснабжения обусловливает напряженную ситуацию с обеспечением питьевой водой в Крыму. За последние несколько лет для решения проблемы на региональном и федеральном уровне были разработаны и реализуются программы модернизации водного хозяйства полуострова. Одной из ключевых задач этих программ является снижение потерь воды, которые в настоящее время достигают 40–60%. Описан комплекс мероприятий, направленных на снижение потерь воды в г. Севастополе. Комплекс мер, разработанный в соответствии с международным опытом и российскими рекомендациями, учитывает существующее состояние системы водоснабжения Крыма. Мероприятия включают в себя создание современного комплекса управления сетями, зонирование водопроводной сети, регулирование давления, мониторинг и устранение утечек. По результатам анализа производственных показателей определено, что первоочередным мероприятием для Севастополя является внедрение современной системы акустического мониторинга на распределительных сетях, которая позволит эффективно обнаруживать скрытые утечки и сэкономить городу тысячи кубометров дефицитной питьевой воды. Описаны результаты пилотного проекта по обследованию 5 км водопроводных сетей системой акустического мониторинга.
The natural scarcity of water resources coupled with a high degree of deterioration of water supply systems result in a tense situation with the drinking water supply in Crimea. Over the past few years, a number of programs of upgrading the peninsula's water industry have been developed and are being implemented in order to solve the problem at the regional and federal levels. One of the key objectives of these programs is to reduce water losses that currently reach 40–60%. A set of measures aimed at reducing water losses in Sebastopol is described. The set of measures developed in accordance with the international experience and Russian recommendations takes into account the current condition of the Crimean water supply system. The activities include designing an advanced network management complex, zoning of the water supply network, pressure regulation, monitoring and elimination of leaks. Based on the results of the analysis of the performance indicators, it was determined that the priority measure for Sebastopol was the introduction of an advanced acoustic monitoring system in the water distribution networks that would provide for detecting effectively latent leaks and saving the city thousands of cubic meters of scarce drinking water. The results of a pilot project on the inspection of 5 km of the water supply networks using the acoustic monitoring system are described.
Characterization of thin films from reflection and transmission ellipsometric parameters
Authors: Jin Lianhua , Mogi Sota , Muranaka Tsutomu , Kondoh Eiichi , Gelloz Bernard 
Published: December 2021

Abstract
Spectroscopic ellipsometry is a powerful tool for the characterization of thin films/surfaces. To simultaneously extract optical constant and film thickness from ellipsometric parameters ψ and Δ, dispersion models of material’s refractive index and spectroscopic ellipsometry measurement have been often required. In this work, we propose an extraction method of optical parameters of thin films from the reflection and transmission ellipsometric parameters. This method necessitates neither spectroscopic information of ψ and Δ, nor dispersion models. Verification measurements were carried out with the single-point and imaging ellipsometers, respectively.
آرَاءُ ابنِ عُدَيْسٍ اللغويّة جَمْعًا ودِرَاسَةً
Authors: الثوابية هيثم 
Published: December 2021

تهدف هذه الدّراسة إلى تسليط الضَّوء على عالم لغويّ أندلسيّ فذّ ابنِ عُديسٍ القضاعيّ، صاحب مجموعة من مُصنفات لُغويّة فُقِدت من المكتبة العربيّة، وهي:" الباهر في المثلث مضافاً إليه المثنيات" و"شرح الفصيح" و" الصّواب في شرح أدب الكاتب"، وتتبعِ آراءه اللغويّة في المصادر التي اتكأ عليها أئمة اللغة والحديث الشّريف، وتحاول أنْ تقارن جهده بجهد غيره بما تحصل إليها من آراء.
وخطّت الدراسة لنفسها منهجًا تسير عليه، فشرعت في الحديث عن ابن عديس من حيث حياته ومكانته العلميّة، ثمّ طفقت تجمع آراءه من المصادر اللغويّة وغيرها، مقسمة إيّاها وفق مباحث لغويّة مُحددة، ثمّ عكفت على دراسة هذه الآراء لتبيان المكانة العلميّة لها، ومقارنة جهد ابن عديس بجهد غيره، وتفسير الآراء قدر ما أمكن.
وقد خلصت الدّراسة إلى أنّ ابن عديس عالم لغويّ فذّ، له مكانته العلميّة التي تستحق تسليط الضَّوء عليها، كما أنّ مؤلفاته المفقودة لها أثر جليّ في مؤلفات اللاحقين عليه، فضلًا على أنّ جهده لا يتمثل بالجمع، إنّما ظهر تفرده ببعض الآراء ومخالفته لآراء بعض اللغويين كقطرب وثعلب وابن قتيبة، فضلًا على أنّنا نجد الكثير من القضايا التي تناولها ولم نجدها عند شراح الفصيح وأدب الكاتب، كما أنّه أضاف بعضًا من المثنيات والمثلثات اللغويّة التي لم تُؤثَر بالكتب المختصّة بذلك.
Investigation of the Optical, Structural and Compositional Properties of Electrodeposited Lead Manganese Sulfide (PbMnS) Thin Films for Possible Device Applications
Authors: Nnaedozie Ezenwaka Laz , Nwode Nwori Augustine , Euphemia Ottih Ifeyinwa , Agatha Okereke Ngozi , Livinus Okoli Nonso 
Published: December 2021

The properties of PbMnS semiconductor thin films deposited on fluorine-doped tin oxide (FTO) substrate using an electrodeposition method are investigated to determine their possible device applications. Lead acetate, manganese sulfate, and thiourea were used as precursors for sources of lead, manganese, and sulfur ions respectively. The concentration of lead, manganese, and sulfur ions sources with deposition voltage of 1.8 V was kept constant. The films were deposited using three electrodes system of electrodeposition method by varying deposition time. The films were characterized for optical, structural, morphological, and compositional properties and results showed that the absorbance, refractive index, and optical conductivity of the films are high in the visible (VIS) and near-infrared (NIR) regions but decreases in the NIR. These three properties initially increased with an increase in deposition time up to a time of 70 s which has the highest values of these properties before decreasing to lower values. The transmittance and extinction coefficient of the films are low in both VIS and NIR regions. The bandgap energy of PbS was found to be blue shifted with values of 1.51 eV, 1.54 eV, 1.60 eV, 1.45 eV, and 1.35 eV for the films deposited at 30 s, 50 s, 70 s, 90 s, and 110 s respectively. XRD analysis showed that the films are crystalline with sharp peaks positions indexable to crystalline planes of (111), (200), (211), (220), (311) and (400) with average crystallite size in the range of 16.110 nm to 17.218 nm. Energy-dispersive X-ray spectroscopy (EDX) results showed that the films are composed of lead, manganese, and sulfur but there are some impurity elements present mostly as a result of the substrate used. These properties exhibited by the deposited thin films of PbMnS showed that they can be used for many optoelectronic applications such as photovoltaic cells, sensors, photoconductors, etc.