bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antiarrhythmic effect of 9-week hybrid comprehensive telerehabilitation and its influence on cardiovascular mortality in long-term follow-up – subanalysis of the TELEREHabilitation in Heart Failure Patients randomized clinical trial
Authors: Orzechowski Piotr , Piotrowicz Ryszard , Zareba Wojciech , Pencina Michael J. , Kowalik Ilona , Komar Ewa , Opolski Grzegorz , Banach Maciej , Główczyńska Renata , Szalewska Dominika , Pluta Sławomir , Irzmański Robert , Kalarus Zbigniew , Piotrowicz Ewa 
Published: May 2021

IntroductionCardiac rehabilitation is a component of heart failure (HF) management, but its effect on ventricular arrhythmias is not well understood. We analyzed the antiarrhythmic effect of a 9-week hybrid comprehensive telerehabilitation (HCTR) program and its influence on long-term cardiovascular mortality in HF patients taken from the TELEREHabilitation in Heart Failure Patients (TELEREH-HF) trial.Material and methodsWe evaluated the presence of non-sustained ventricular tachycardia (nsVT) and frequent premature ventricular complexes ≥ 10 beats/hour (PVCs ≥ 10) in 24-hour ECG monitoring at baseline and after 9-week HCTR or usual care (UC) of 773 HF patients (NYHA I-III, LVEF ≤ 40%). Functional response for HCTR was assessed by changes – delta () – in peak oxygen consumption (pVO2) as a result of comparing pVO2 from the beginning and the end of the program.ResultsAmong 143 patients with nsVT, arrhythmia subsided in 30.8% after HCTR. Similarly, among 165 patients randomized to UC who had nsVT 34.5% did not show it after 9 weeks (p = 0.481). There was no significant difference in the decrease in PVC ≥ 10 over 9 weeks between randomization arms (14.9% vs. 17.8%, respectively p = 0.410). Functional response for HCTR in ΔpVO2 > 2.0 ml/kg/min did not affect occurrence of arrhythmias. Multivariable analysis did not identify HCTR as an independent factor determining improvement of nsVT or PVCs ≥ 10. However, only in the HCTR group, the achievement of the antiarrhythmic effect significantly reduced the cardiovascular mortality in 2-year follow-up (p < 0.001).ConclusionsSignificant improvement in physical capacity after 9 weeks of HCTR did not correlate with the antiarrhythmic effect in terms of incidence of nsVT or PVCs ≥ 10. An antiarrhythmic effect after the 9-week HCTR affected long-term cardiovascular mortality in HF patients.
IL-33 / ST2 Signaling Promotes TF Expression by Regulating NF-κB Activation in Coronary Artery Endothelial Microparticles
Authors: Yuan Yujuan , Cheng Hui , Tao Jing , Nijiati Muyesai 
Published: May 2021

IntroductionInterleukin (IL)-33 was previously shown to induce angiogenesis and inflammatory activation of endothelial Microparticles(EMPs). Tissue factor (TF) plays a central role in hemostasis and thrombosis.Material and methodsThe study analyzed the coronary blood of level of CD31+EMPs, TF protein and IL-33 protein in Acute Myocardial Infarction (AMI) and stable coronary artery disease (SCAD) patients. Human coronary artery endothelial cells (HCAECs) were treated with IL-33 to obtain EMPs. The TF activity of EMPs was tested by Thermo Fisher by adding the TF antibody. Furthermore, TF and Tissue Factor Pathway Inhibitor (TFPI) protein were tested by ELISA. Finally, NF-κB inhibitor dimethyl fumarate (DMF) and soluble extracellular domain of ST2 coupled to the Fc fragment of human IgG1 (sST2) were added to HCAECs which were treated with IL-33, and the TF protein level was also tested by ELISA.ResultsThe AMI patients had higher level of CD31+EMPs, TF protein and IL-33 protein than the SCAD patients in coronary artery. In AMI patients (N=27), the IL-33 protein positively correlated with CD31+EMPs (r=0.794, p<0.01). According to the ROC curve analysis, the AUC of CD31+EMPs, TF protein and IL-33 protein were 0.888, 0.962 and 0.778 respectively. In the cell culture, the TF activity and TF protein in EMPs increased gradually with time of intervention by the treatment of IL-33. IL-33 binding to the ST2 receptor promoted TF expression by regulating NF-κB activation in EMPs of HCAECs.ConclusionsActivated endothelial cells and EMPs they released simultaneously express TF, which is a risk factor for cardiovascular disease.
Analisis Faktor Pendorong Minat Masyarakat Terhadap Usaha Peternakan Ayam Broiler Dengan Pola Kemitraan Di Kecamatan Karangpawitan Kabupaten Garut
Authors: Maryani Dewi , Herawati Ervi , Kusmayadi Tendy , Rohayati Tati , Nurhayatin Titin 
Published: May 2021

Peternakan ayam broiler merupakan salah satu usaha peternakan yang memberikan kontribusi terbanyak dalam memenuhi kebutuhan pangan hewani di Indonesia, yang paling utama adalah meningkatkan pendapatan.Â Penelitian ini bertujuan untuk menganalisis minat masyarakat terhadap usaha peternakan ayam broiler dengan pola kemitraan di Kecamatan Karangpawitan Kabupaten Garut, yang dilakukan pada bulan April 2020. Metode penelitian yang digunakan adalah metode sensus, dengan jumlah responden sebanyak 30 peternak. Teknik pengumpulan data yang digunakan adalah kuesioner, dengan jenis data dikuantitatifkan. Pengukuran minat masyarakat dalam beternak ayam broiler dengan menggunakan skala Liekert. Hasil penelitian yang diperoleh menunjukkan bahwa faktor-faktor yang mempengaruhi minat masyarakat terhadap usaha ayam broiler di Kecamatan Karangpawitan Kabupaten Garut adalah modal (puas); jaminan pasar (sangat puas); jaminan harga dan nilai ekonomis (sangat puas). Faktor yang paling berpengaruh adalah jaminan harga.Kata kunci: analisis, minat masyarakat, pola kemitraan, ayam broiler.
Pengaruh Imbangan Rumput Dan Konsentrat Terhadap Ukuran Tubuh Domba Garut Jantan Umur Lima Sampai Delapan Bulan
Authors: Maulana Ahmad , Hadist Ibrahim , Ayuningsih Budi 
Published: May 2021

Penelitian ini bertujuan untuk mengetahui imbangan rumput dan konsentrat terhadap ukuran tubuh Domba Garut umur lima sampai delapan bulan. Penelitian dilaksanakan pada bulan Juni sampai Agustus 2019 di UPTD BPPTDK Margawati Garut. Metode yang digunakan adalah metode eksperimental menggunakan Rancangan Acak Lengkap (RAL) dengan tiga perlakuan dan enam ulangan. Ternak percobaan yang digunakan yaitu 18 ekor Domba Garut jantan umur lima sampai delapan bulan. Hasil penelitian menunjukan bahwa P3 (40% Rumput : 60%), berpengaruh terhadap lebar dada dan panjang badan akan tetapi tidak mempengaruhi terhadap lingkar dada dan tinggi pundak.Kata Kunci :Â Rumput, Konsentrat, Ukuran Tubuh, Domba Garut.
Pengaruh Substitusi Dedak Padi Dengan Bonggol Pisang Terfermentasi Terhadap Sifat Fisik Pellet
Authors: Raharja Slamet , Nurhayatin Titin , Herawati Ervi 
Published: May 2021

Penelitian ini bertujuan untuk mengetahui pengaruh dari substitusi dedak padi dengan bonggol pisangÂ terfermentasi terhadap kerapatan tumpukan, kerapatan pemadatan tumpukan, berat jenis, dan sudut tumpukan pellet. Persiapan bahan dan Pengujian sifat fisik pellet dilaksanakan di Laboratorium terpadu Fakultas Pertanian Universitas Garut. MetodeÂ yang digunakan dalam penelitian ini yaitu metode eksperimental dengan menggunakan Rancangan Acak Lengkap (RAL) terdiri dari 5 perlakuan dan 4 ulangan, yaitu : R0 (dedak padi 5%, bonggol pisang terfermentasi 0%), R1 (dedak Padi 3,75%, bonggol pisang terfermentasiÂ 1,25%), R2 ( dedak padi 2,5%, bonggol pisang terfermentasi 2,5%), R3 (dedak padi 1,25%, bonggol pisang terfermentasi 3,75%), dan R4 (dedak padi 0%, bonggol pisang terfermentasi 5%).Â Data penelitian dianalisis menggunakan sidik ragam dan bila hasilnya berbeda nyata dilanjutkan dengan Uji Jarak Berganda Duncan untuk melihat perbedaan antar perlakuan. Hasil penelitian menunjukkan bahwa substitusi dedak padi dengan bonggol pisangÂ terfermentasi berpengaruhÂ terhadap kerapatan tumpukan dan kerapatan pemadatan tumpukan, tetapi tidak berpengaruhÂ terhadap berat jenis dan sudut tumpukan pellet. Perlakuan paling optimal yaitu pada perlakuan R1 (dedak padi 3,75%, bonggol pisang terfermentasi 1,25%).Kata kunci: Bonggol Pisang Terfermentasi, Pellet, Sifat fisik.
RESEARCH AT CROSSROADS: A CRITIQUE OF MASTERâ€™S LEVEL RESEARCH IN EDUCATION
Authors: Paramjit K Tulsi  
Published: May 2021

Research at higher levels of education offers a picture of decline. This is particularly with respect to curriculum-making, feedback, control mechanisms, inadequate availability of competent teachers, etc. The problem has been noted by Government agencies as well as independent scholars and researchers. What is lacking is clear methodology under which fruitful interaction between young researchers vis-Ã -vis the chosen area of study could take place. This paper investigates a number of aspects related to research in higher education and suggests a corrective paradigm.
Assessment on Drinking Water Handling and Sanitation Practices in an Urban Community of Imphal East, Manipur: A Cross-Sectional Study
Authors: Oinam Joymati , Ningombam Joenna Devi 
Published: May 2021

Background: According to SDG 6: Clean water and sanitation, each day, nearly 1000 children die due to preventable water and sanitation-related diarrheal diseases. The objectives of the study were to assess drinking water handling and sanitation practices in an urban community and its association with selected variables of interest.
Methods: A cross-sectional study was conducted among 150 married women with under-five children from May to June 2018. From a randomly selected village in an urban community, participants were selected by convenience sampling. A predesigned, semi-structured questionnaire was used. Statistical tests like mean, SD, Chi-squared test, Fischer Exact test were used taking p-value <0.05 as statistically significant.
Results: Only 18.9% of the respondents had improved main source of drinking water. Almost all (98%) had improved sanitation facilities of household. Statistically significant association were found between mothers with more than 30 years age group with adequate status of water treatment, sanitary status of under-five stool disposal and higher educational status of mothers with improved status of water treatment, sanitary status of under-five stool disposal.
Conclusion: Only one-fifth of the respondents had improved main source of drinking water. Awareness campaigns should be conducted focusing on adequate water treatment and sanitary method of under-five stool disposal practices.
Identification of Mixed Virus Infection on Trichosanthes cucumerina L. in Akamkpa, Southern Cross River State, Nigeria
Authors: Eyong O. I. , Ekpiken E. E. , Akam D. E. , Owolabi A. T. 
Published: May 2021

Trichosanthes cucumerina L is a tropical or subtropical fruit bearing crop of the Cucurbitaceae family. Field survey during 2020 planting season in Akamkpa, Southern Cross River State, Nigeria revealed widespread virus infection of the crop. Symptoms observed included severe leaf malformation/reduction and rugosity. This research was therefore aimed at identifying viruses infecting Trichosanthes cucumerina in this location. Infected leaf samples were collected and virus maintained on young seedlings of T. cucumerina in the Botanical Garden of University of Calabar, Nigeria. Diagnostic tools included ACP-ELISA and gene sequence analysis. The ELISA result revealed two viruses belonging to the genus Cucumovirus and Potyvirus. The identity of the viruses were determined after virus sequences were compared with other viruses available in the GenBank of National Centre for Biotechnology Information (NCBI) using the basic local alignment search tool (BLASTn). The result revealed the Cucumovirus to be Cucumber mosaic virus (CMV) while the Potyvirus was revealed to be Potato virus Y (PVY). This is the first report of mixed virus infection on Trichosanthes cucumerina in Nigeria.
Prevalence and Antibiotic Susceptibility Pattern of Salmonella Species
Authors: Alhassan A. R. , Saba C. K. S. , Kpordze S. W. 
Published: May 2021

Aim: This research was carried out to determine the prevalence of Salmonella species from smoked fish sold in the three major markets in Tamale Metropolis and examined the isolates resistance patterns to various antibiotics.
Study Design: The study was in two parts which include administering questionnaires and collecting samples. The second part was the laboratory analysis to detect Salmonella species from the collected samples.
Place and Duration of Study: The study was carried out in the Spanish laboratory (microbiology section) of the Department of Biotechnology, Faculty of Biosciences, of the University for Development Studies.
Methodology: A total of one hundred samples were examined. The samples were enriched on buffered peptone water and inoculated on Modified Semi-Solid Rappaport Vassiliadis. Xylose Lysine Deoxycholate was used to identify the bacteria, and Simons Citrate agar was used for the biochemical test. The antibiotic test was done by using the Kirby-Bauer disc diffusion test.
Results: After the laboratory analysis, 67 (67%) out of the 100 samples were confirmed to be positive for Salmonella species of which Cut fish (11.9%), Redfish (11.9%), Mudfish (11.9%), and Chale fish (11.9%) recorded the highest contamination, and among the three markets, Central market had the highest fish contamination. The resistance patterns of the isolates to the various antibiotics used were; Ciprofloxacin (2.98%), Ceftriaxone (34.32%), Ampicillin (83.58%), Doxycycline (88.05%), Amoxicillin/Clavulanic acid (91.04%), and Oxytetracycline (92.53%).
Conclusion: This study revealed that smoked fish sold in the Tamale Metropolis contained Salmonella positive that can cause food poisoning and other gastrointestinal problems.
Toxicity of Azadirachta indica Hydroethanolic Leaf Extract in Adult Drosophila melanogaster (Harwich Strain)
Authors: Tochukwu Okoye Clifford , Alexander Etuh Monday , Salu Jacob Mekidani 
Published: May 2021

Aim: This study is aimed at evaluating the toxic effect of A. indica hydroethanolic leaf extracts in D. melanogaster (fruit flies) by carrying out a survival study, locomotor, fecundity and biochemical assays.
Place of study: This study was carried out in the Drosophila laboratory of Africa Centre of Excellence in Phytomedicine Research and Development (ACEPRD), University of Jos.
Methods: Extraction of A. indica extract was carried using hydroethanolic solvent (70:30 v/v ethanol: water). Flies were treated with 5 mg, 10 mg, 20 mg, 50 mg, 100 mg, 250 mg, 500 mg and 5000 mg A. indica hydroethanolic leaf extracts per 10 g fly food for 7 days, to determine the lethal concentration (LC50). The survival assay was carried out for 28 days by treating flies with 5 mg, 10 mg, and 25 mg/10 g fly food of the extract. Young flies were treated with several concentrations of the extract for 7 days, to determine the effect of the extract on the fecundity and locomotion. Thereafter, flies exposed to the extracts for 7 days were immobilized, weighed, homogenized, and centrifuged. The supernatant was used to assay for acetylcholinesterase and catalase activities. The experiment was replicated 3 times and data was presented as mean ± SEM with statistical value at “P < 0.05” considered significant.
Results: The percentage yield was calculated to be 12.7 % and the phytochemicals present in A. indica hydroethanolic leaf extract included alkaloids, flavonoids, saponins, tannins, steroids, phenols, and glycosides. The LC50 was determined to be 1499 mg/10 g diet and the result showed a dose-dependent significant decrease (P < 0.05) in the survival of the flies, when compared to the control group. Further results showed a non-significant decrease (P > 0.05) in the fecundity, as well as the locomotor, acetylcholinesterase, and catalase activities of the flies, compared to the control.
Conclusion: This study concludes that A. indica hydroethanolic leaf extract, at certain concentrations, may not be safe for consumption as it showed some level of toxicity in D. melanogaster.
Sexual Behaviour, Needs and Concerns Regarding Sexual and Reproductive Health among Adults Living with HIV in Sub-Saharan Africa- A Systematic Review
Authors: Ofurum Ifeoma Chinyere 
Published: May 2021

Background: The sexual and reproductive health of people living with HIV in sub-Saharan Africa should be of paramount importance and, therefore, given the attention it deserves. The advent of antiretroviral therapy (ART) and subsequent access to it has aided millions of infected people to live a normal life. However, being on ART is not enough as most of these people despite being on the therapy are faced with needs and concerns that have shaped their sexual behaviour.
This review aims to bring to perspective the sexual behaviour, needs, and concerns regarding the sexual and reproductive health of adults living with HIV in sub-Saharan Africa (SSA) with a view to reducing the disease's ultimate burden in the region.
Method: An extensive search of articles was carried out using the reporting systematic review and meta-analysis (PRISMA). The database search was from JSTORE, Scopus, Google Scholar, Medline, Cochrane, Semantic scholar, and Pubmed.
Results: A total of 3,984 results were obtained from the search. The application of the inclusion and exclusion criteria finally gave ten studies which were reviewed. The review revealed, among other things, that a good number of adults living with HIV have multiple sex partners, and some still have sex without condoms. Besides, most of them indicated the need for their own biological children, especially after being on ART for a while. Some women living with HIV in SSA do not have a right to decide on their sexual and reproductive health.
Recommendation: It was recommended that there be intense re-orientation and health education for this group of people. Women need to be empowered and taught their rights.
Metastatic Cholangiocarcinoma in the Absence of Jaundice Presenting with Neck Swelling in District Hospital
Authors: Rahman Mohd Shafiq , Salleh Norly 
Published: May 2021

Introduction: Cholangiocarcinoma is a malignancy arising from biliary epithelium with incidence rate of less than 2 in 100000. It is the second most common primary liver malignancy. Cholangiocarcinoma usually presents with jaundice with or without abdominal pain. In advanced cholangiocarcinoma, it is extremely rare for cervical swelling to be the initial complaint and presentation.
Case Presentation: A 69-year-old male with underlying diabetes mellitus presented to surgical clinic with painful neck cervical swelling for 1 month with no other associated symptoms. Blood investigations were within normal range. Contrast enhanced computer tomography showed multiple enlarged lymph nodes over the axilla, mediastinal and supraclavicular with small hypodense lesion identified at Segment IV of the liver. Excision biopsy of left supraclavicular was performed which revealed metastatic adenocarcinoma. Immunohistochemistry study with an elevated Ca 19.9 tumour marker confirmed the diagnosis of metastatic cholangiocarcinoma.
Conclusion: Metastatic cholangiocarcinoma presenting with neck swelling in the absence of jaundice is a rare occurrence and confer diagnostic challenge especially in district hospital. Availability of immunohistochemical study is of paramount important in establishing the diagnosis.
Problems and Prospects of Tourism Industry in Bangladesh: A Study on Cumilla District
Authors: Islam S. M. Nazrul , Akter Sk. Rahima 
Published: May 2021

Tourism is one of the most growing industries all around the world. Bangladesh is a new tourist destination on the map of the world. Bangladesh has enormous potential to develop tourism because of its attractive natural beauty and rich cultural heritage. The tourism industry of Bangladesh has several positive impacts on the overall economy of this country. Tourism can add value to the Bangladeshi economy if a proper marketing plan and strategy can be built and implemented for this purpose. The main objective of the study was to find out the major problems and prospects of the tourism industry in Bangladesh. The study area was Cumilla District. The study has tried to highlight the special attractive tourist spots of Bangladesh, especially in Cumilla. Tourists of Cumilla District were the population of the study. For the study, a convenient sample of tourists from various tourist spots in the Cumilla District had taken. The study depended on both primary and secondary data; primary data were collected with a structured questionnaire and analyzed. From the analysis, it was found that the majority of the respondents are satisfied with cultural & religious heritage, transportation quality & cost efficiency. But they are dissatisfied with Information gaps, the absence of tour operators, poor service of hotel & poor security. Most of them suggest developing infrastructure such as accommodation, transportation, ensuring security, taking more promotional activities, reducing the cost of touring, etc. To enhance the existing image sincere steps of the concerned authorities can really be helpful; some guidelines have been mentioned in the recommendation part.
Risk for second bladder and rectal malignancies from cervical cancer irradiation
Authors: Mazonakis Michalis , Lyraraki Efrosyni , Tolia Maria , Damilakis John 
Published: May 2021

AbstractThe objective of this study was to estimate the risk of developing second malignancies to partially in‐field organs from volumetric modulated arc therapy (VMAT) of cervical cancer and to compare the above risks with those from the conventional three‐dimensional conformal radiotherapy (3D‐CRT). Seventeen consecutive patients with uterine cervix carcinoma were selected. VMAT and 3D‐CRT plans were generated with 6 and 10 MV photons, respectively. The prescribed tumor dose was 45 Gy given in 25 fractions. Differential dose‐volume histogram data from the treatment plans were obtained for the partially in‐field organs such as bladder and rectum. These data were used to estimate the patient‐specific lifetime attributable risk (LAR) for bladder and rectal cancer induction with a non‐linear model based on a mixture of plateau and bell‐shaped dose–response relationships. The estimated risks per 10000 people were compared with the baseline risks for unexposed population. The patient‐specific rectal cancer risk estimates from VMAT were significantly lower than those from 3D‐CRT (P = 0.0144). The LARs for developing bladder malignancies from VMAT were significantly high compared to those from conventional irradiation (P = 0.0003). The mean difference between the patient‐specific LARs for radiation‐induced bladder and rectal malignancies as derived from 3D‐CRT and VMAT plans was 6.6% and 2.0%, respectively. The average LAR for developing bladder and rectal malignant diseases due to VMAT was 9.2 × 10‐4 and 43.7 × 10‐4, respectively. The corresponding risks following 3D‐CRT were 8.6 × 10‐4 and 44.6 × 10‐4. These average risks showed that pelvic irradiation increases the baseline probability for cancer induction by 12.6‐19.1%. The differences in the second cancer risks associated with the VMAT and 3D‐CRT for cervical cancer were found to be small. Both treatment techniques resulted in considerable increased probabilities for developing bladder and rectal malignancies relative to those of unirradiated population.