bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kozachyi Yar 1: An enclosed Trypillian settlement on the Southern Bug River in Kozavchyn (Ukraine)
Authors: Saile Thomas , Posselt Martin , Dębiec Maciej , Lobanova Mariia , Peresunchak Aleksander 
Published: October 2021

Summary
In Kozavchyn on the Southern Bug, an Early Copper Age settlement surrounded by trenches was explored by means of field surveys and magnetic prospection. In addition to the enclosing trenches, the magnetogram revealed a palisade trench and remains of pits and burnt houses, which covered a contiguous area with archaeological findings of almost 4 ha situated on a spur with the field name “Kozachyi Yar”. The settlement belongs to the Trypillia BI local group Sabatynivka, as does the nearby site Kamyane, “Kamyane-Zavallia 1”, also surrounded by ditches, which was investigated a few years ago and dated to the last third of the 5th millennium BC. The Sabatynivka group is documented in a narrowly confined area on both sides of the Southern Bug River and may have once been a jointly acting political entity. Internal conflicts or external threats from the steppe area to the east are often considered as reasons for the enclosure of CTCC settlements. It seems conceivable, however, that the apparently once much more numerous enclosures had less of a protective than merely a delimiting character.
Immobilization-induced hypercalcemia in a patient with renal failure
Authors: Gandhi Anand , Mortensen Mike , Sunny Sonie , Techathaveewat Pawarid , Targovnik Jerome , Alsayed Mahmoud 
Published: October 2021

Summary
Immobilization-induced hypercalcemia is an uncommon cause of elevated calcium which is usually diagnosed following extensive systemic workup and exclusion of more common etiologies. Previously reported cases have largely described this phenomenon in adolescents and young adults a few weeks to months after the initial onset of immobilization. Metabolic workup tends to demonstrate hypercalcemia, hypercalciuria, and eventual osteoporosis. While the exact mechanism remains largely unclear, a dysregulation between bone resorption and formation is central to the pathogenesis of this disease. Decreased mechanical loading from prolonged bedrest tends to increase osteoclast induced bone resorption while promoting osteocytes to secrete proteins such as sclerostin to reduce osteoblast mediated bone formation. We describe the case of an 18-year-old male who was admitted following intraabdominal trauma. He underwent extensive abdominal surgery including nephrectomy resulting in initiation of dialysis. After 6 months of hospitalization, the patient gradually began developing uptrending calcium levels. Imaging and laboratory workup were unremarkable for any PTH-mediated process, malignancy, thyroid disorder, adrenal disorder, or infection. Workup did reveal significant elevated bone turnover markers which in combination with the clinical history led the physicians to arrive at the diagnosis of immobilization induced hypercalcemia. In order to prevent decreased rates of bone loss, the patient was administered denosumab for treatment. Hypocalcemia followed treatment expectedly and was repleted with supplementation via the patient’s total parenteral nutrition.

Learning points

Immobilization-induced hypercalcemia should remain as a differential diagnosis of patients with prolonged hospitalizations with hypercalcemia.

Extensive workup of common etiologies of hypercalcemia should be considered prior to arriving at this diagnosis.

Denosumab, while off-label for this usage, offers an effective treatment option for immobilization-induced hypercalcemia though it carries a risk of hypocalcemia especially among patients with renal disease.
First-generation somatostatin ligand receptor treatment in a pregnant patient with a neuroendocrine tumor with liver metastases
Authors: Hummelshøj Nynne Emilie , Dam Gitte , Pedersen Lars Henning , Hjelholt Astrid , Villadsen Gerda Elisabeth 
Published: October 2021

Summary
This rare case describes the course of a pregnancy in a patient with a disseminated small intestinal neuroendocrine tumor. The patient received treatment with first-generation somatostatin ligand receptor (SLR) every 4 weeks and had stable disease for several years before her pregnancy. First-generation SLR treatment was initially paused after detection of the pregnancy. During pregnancy, the patient experienced moderate gastro-intestinal discomfort and fatigue, which was considered predominantly pregnancy related. However, since symptoms could be linked to the patient’s cancer, treatment was resumed after the first trimester. Chromogranin-A measurements remained stable throughout pregnancy and was paralleled by the absence of diarrhea and only minor flushing. She gave birth by elective caesarean section in week 37 to a healthy baby. Subsequent follow up imaging immediately after and 10 months postpartum showed no disease progression. The safety profile of SLR treatment during pregnancy in the context of disseminated neuroendocrine tumors (NET) is discussed.

Learning points

Neuroendocrine neoplasms (NEN) are rare cancers often occurring in the gastro-intestinal tract or lungs.

Many patients with NEN live for several years with disseminated disease.

SLR treatment has been given to pregnant patients before; often patients with acromegaly. Pregnancies are reported uneventful.

This patient completed an uneventful pregnancy while receiving SLR treatment for disseminated neuroendocrine disease and gave birth to a healthy baby.

More research regarding long term effects and safety signals of SLR treatment during pregnancy are much needed.
Missplicing due to a synonymous, T96= exonic substitution in the T-box transcription factor TBX19 resulting in isolated ACTH deficiency
Authors: Maudhoo Ashwini , Maharaj Avinaash , Buonocore Federica , Martos-Moreno Gabriel Angel , Argente Jesús , Achermann John C , Chan Li F , Metherell Lou A 
Published: October 2021

Summary
Congenital isolated ACTH deficiency (IAD) is a rare condition characterised by low plasma ACTH and serum cortisol with normal production of other pituitary hormones. TBX19 (also known as TPIT) is a T-box pituitary restricted transcription factor important for POMC gene transcription and terminal differentiation of POMC-expressing cells. TBX19 gene mutations have been shown to cause neonatal-onset congenital IAD. We report a neonate of Romanian origin, who presented at 15 h of life with respiratory arrest and hypoglycaemia which recurred over the following 2 weeks. Biochemical investigations revealed IAD, with undetectable serum cortisol (cortisol < 1 μg/dL; normal range (NR): 7.8–26.2) and plasma ACTH levels within the normal range (22.1 pg/mL; NR: 4.7–48.8). He responded to hydrocortisone treatment. Patient DNA was analysed by a HaloPlex next-generation sequencing array targeting genes for adrenal insufficiency. A novel homozygous synonymous mutation p.Thr96= (Chr1:168260482; c.288G>A; rs376493164; allele frequency 1 × 10−5, no homozygous) was found in exon 2 of the TBX19 gene. The effect of this was assessed by an in vitro splicing assay, which revealed aberrant splicing of exon 2 giving rise to a mutant mRNA transcript whereas the WT vector spliced exon 2 normally. This was identified as the likely cause of IAD in the patient. The predicted protein product would be non-functional in keeping with the complete loss of cortisol production and early presentation in the patient.

Learning points

Synonymous variants (a nucleotide change that does not alter protein sequence) usually thought to be benign may still have detrimental effects on RNA and protein function causing disease. Hence, they should not be ignored, especially if very rare in public databases.

In vitro splicing assays can be employed to characterise the consequence of intronic and exonic nucleotide gene changes that may alter splicing.

Establishing a diagnosis due to a TBX19 mutation is important as it defines a condition of isolated ACTH deficiency not associated with additional pituitary deficiencies.
Enhanching Student’s Memorization Skill of Holy Qur’an Trough the Integrated Tahfidz Program Implementation in Post Pandemic Context
Authors: Supendi Pepen , Kurniawati Nia , Sofyan Muhammad , Mulyana Kresna Dewi 
Published: October 2021

The purpose of this paper implementation of the tahfiz program in MI Terpadu Ar-Rifqi Cileunyi district for the 2020/2021 academic year; Inhibitor and backups of the tahfiz program in MI Terpadu Ar-Rifqi Cileunyi district for the 2020/2021 academic year; Tahfiz program effectiveness in improving rote at the MI Terpadu Ar-Rifqi Cileunyi district for the 2020/2021 academic year. The study involves a qualitative approach with a type of case study. The method used is a qualitative descriptive method. Data is obtained from observation, interview and documentation and then analyzed by data reductin, data display and conclusions drawing nad verification. Studies have found that include the tahfiz program goals, teachers tahfiz, tahfiz materials, tahfiz methods, memorizing the Qur’an color block, talaqqi and muraja’ah, an evaluation of daily, weekly and semester assessments and the supporting and inhibiting factors for the implementation of the tahfiz program at the MI Terpadu Ar-Rifqi. Of the increased aspects of surah that memorized by learners, the effectiveness of tahfiz programs falls into highly effective categories. According to the tahfiz materials, the effectiveness of tahfiz programs is highly ineffective.
Entropic Explanation of Power Set
Authors: Song Yutong , Deng Yong 
Published: October 2021

A power set of a set S is defined as the set of all subsets of S, including set S itself and empty set, denoted as P(S) or 2S. Given a finite set S with |S|=n hypothesis, one property of power set is that the amount of subsets of S is |P(S)| = 2n. However, the physica meaning of power set needs exploration. To address this issue, a possible explanation of power set is proposed in this paper. A power set of n events can be seen as all possible k-combination, where k ranges from 0 to n. It means the power set extends the event space in probability theory into all possible combination of the single basic event. From the view of power set, all subsets or all combination of basic events, are created equal. These subsets are assigned with the mass function, whose uncertainty can be measured by Deng entropy. The relationship between combinatorial number, Pascal's triangle and power set is revealed by Deng entropy quantitively from the view of information measure.
Intervention of Hydration Protocol on Strength, Endurance, and Muscle Power Performance
Authors: Ramadhan Wahyu Syahrul , Lubis Leonardo , Oktavia Nandina , Womsiwor Daniel , Tarigan Beltasar 
Published: October 2021

Water is a molecule that plays an essential role in the muscle contraction process because muscle is a tissue that mostly contains water (75-80%). Therefore, athletes need to maintain fluid intake to support their physical activities when competing and when training. Nevertheless, in several studies, it was noted that some athletes experienced hypohydration or dehydration, which ultimately impaired muscle performance. Therefore, this study was conducted to determine the hydration protocol intervention on muscle strength, endurance, and power performance. This research is an analytical study with quasi-experimental research methods, namely single-arm pre-post study design using secondary data. Subjects of this study were 69 athletes year 2020 (named consecutively: Muaythai 9, Pencak silat 12, wrestling 10, judo 18, and taekwondo 20 athletes). This research was conducted from December 2019 to January 2020. In the beginning, all athletes were tested for muscle strength using a leg dynamometer, then muscle endurance tests using push-up and sit-up tests, and muscle power tests using the triple hop test of the right and left legs. After the first test, all athletes were educated about the hydration protocol. The hydration protocol was determined based on each athlete's sweat rate (ISR) and the training characteristics of each sports division. Then, all athletes underwent the training for two months. After that, the same tests were performed. The result showed that hydration protocol influenced the performance of muscle strength, endurance, and power. Therefore, the hydration protocol is influential in maintaining a good hydration status in athletes so that the athlete does not experience hypohydration which will later impair the athlete's muscle performance. Therefore, it is crucial to apply hydration protocols individually according to the training program (volume of training), not only in martial arts sports but in all sports.
Inertial sensors-determined match characteristics that serve as predictors of elite, male badminton players’ performance levels
Authors: Abdullahi Yahaya , Coetzee Ben 
Published: October 2021

The study's purpose was to establish the inertial sensors-containing device (ISCD)-determined match characteristics that predict elite, male badminton players’ performance levels. Twenty-two (22) male single players (aged: 23.39 ± 3.92 years), who represented 10 African countries, participated in the study. Players were categorized as successful and less-successful players according to the results of five championships during two seasons. ISCD units (Catapult MinimaxV4), Polar Heart Rate Transmitter Belts, and digital video cameras were used to collect match data. ISCD-determined variables were corrected for match duration, and independent t-tests, cluster analysis, and a binary forward stepwise logistic regression were used for statistical analyses. A Receiver Operating Characteristic Curve (ROCC) indicated the validity of the group classification model. High-intensity accelerations per second were identified as the only ISCD-determined variable that showed a significant difference (p = 0.05) between groups. Furthermore, only high-intensity accelerations per second (p = 0.03) and low-intensity efforts per second (p = 0.04) were identified as significant predictors of group classification, with 76.88% of players that could be classified back into their original groups by making use of the ISCD-based logistic regression formula. The ROCC showed a value of 0.87. The identification of the last-mentioned ISCD-determined variables for the attainment of badminton performances emphasizes the importance of using badminton drills and conditioning techniques to improve not only the physical fitness levels of players but also their ability to accelerate at high intensities.
Editorial Board and Guidelines for the Authors
Authors: MIMBARDIK Editor Journal 
Published: October 2021

MIMBAR PENDIDIKAN: Jurnal Indonesia untuk Kajian Pendidikan(Indonesian Journal for Educational Studies)This journal, with ISSN 2527-3868 (print) and 2503-457X (online), was firstly published on March 11, 2016, by UPI (Indonesia University of Education) Press in Bandung and orgnized by the Lecturers of UPI Journal Developer Team. The MIMBAR PENDIDIKAN is a new version journal from the old journal with the similar name that was published since 1995 to 2005. This journal is dedicated not only for Indonesian scholars who concern about educational studies, but also welcome to the scholars of Southeast Asian countries and around the world who care and share related to the educational studies in general. The MIMBAR PENDIDIKAN journal is published twice a year i.e. every March and September. Bandung, Indonesia: March 30, 2017.Prof. Dr. Didi SukyadiEditor-in-Chief of MIMBAR PENDIDIKAN Journal; and Vice Rector IV UPI in Bandung, West Java, Indonesia.
Info-edu-tainment of MIMBARDIK Journal, Issue of September 2017
Authors: MIMBARDIK Editor Journal 
Published: October 2021

MIMBAR PENDIDIKAN: Jurnal Indonesia untuk Kajian Pendidikan (Indonesian Journal for Educational Studies) This journal, with ISSN 2527-3868 (print) and 2503-457X (online), was firstly published on March 11, 2016, by UPI (Indonesia University of Education) Press in Bandung and orgnized by the Lecturers of UPI Journal Developer Team. The MIMBAR PENDIDIKAN is a new version journal from the old journal with the similar name that was published since 1995 to 2005. This journal is dedicated not only for Indonesian scholars who concern about educational studies, but also welcome to the scholars of Southeast Asian countries and around the world who care and share related to the educational studies in general. The MIMBAR PENDIDIKAN journal is published twice a year i.e. every March and September. Bandung, Indonesia: September 30, 2017.Andi SUWIRTAAssociate Editor of the MIMBAR PENDIDIKAN Journal in Bandung, West Java, Indonesia.
Contents and Forewords of the MIMBARDIK Journal, Issue of September 2017
Authors: MIMBARDIK Editor Journal 
Published: October 2021

MIMBAR PENDIDIKAN: Jurnal Indonesia untuk Kajian Pendidikan (Indonesian Journal for Educational Studies) This journal, with ISSN 2527-3868 (print) and 2503-457X (online), was firstly published on March 11, 2016, by UPI (Indonesia University of Education) Press in Bandung and orgnized by the Lecturers of UPI Journal Developer Team. The MIMBAR PENDIDIKAN is a new version journal from the old journal with the similar name that was published since 1995 to 2005. This journal is dedicated not only for Indonesian scholars who concern about educational studies, but also welcome to the scholars of Southeast Asian countries and around the world who care and share related to the educational studies in general. The MIMBAR PENDIDIKAN journal is published twice a year i.e. every March and September. Bandung, Indonesia: September 30, 2017.Prof. Dr. H.R. Asep KadarohmanHonorable Patron of MIMBAR PENDIDIKAN Journal and Rector of UPI in Bandung, West Java, Indonesia.
Editors and Guidelines for the Authors, MIMBAR PENDIDIKAN Journal, Issue of September 2018
Authors: Mimbar Pendidikan Editors & Guidelines Journal 
Published: October 2021

MIMBAR PENDIDIKAN: Jurnal Indonesia untuk Kajian Pendidikan (Indonesian Journal for Educational Studies) This journal, with ISSN 2527-3868 (print) and 2503-457X (online), was firstly published on March 11, 2016, by UPI (Indonesia University of Education) Press in Bandung and orgnized by the Lecturers of UPI Journal Developer Team. The MIMBAR PENDIDIKAN is a new version journal from the old journal with the similar name that was published since 1995 to 2005. This journal is dedicated not only for Indonesian scholars who concern about educational studies, but also welcome to the scholars of Southeast Asian countries and around the world who care and share related to the educational studies in general. The MIMBAR PENDIDIKAN journal is published twice a year i.e. every March and September.Bandung, West Java, Indonesia: September 30, 2018.Prof. Dr. Didi SukyadiEditor-in-Chief of MIMBAR PENDIDIKAN Journal; and Vice Rector IV UPI, Indonesia University of Education, Bandung, Indonesia. E-mail: dsukyadi@upi.edu
Info-MIMBARDIK-Edutainment, Issue of September 2019
Authors: MIMBAR PENDIDIKAN Editor Journal 
Published: October 2021

MIMBAR PENDIDIKAN: Jurnal Indonesia untuk Kajian Pendidikan (Indonesian Journal for Educational Studies) This journal, with ISSN 2527-3868 (print) and 2503-457X (online), was firstly published on March 11, 2016, by UPI (Indonesia University of Education) Press in Bandung and orgnized by the Lecturers of UPI Journal Developer Team. The MIMBAR PENDIDIKAN is a new version journal from the old journal with the similar name that was published since 1995 to 2005. This journal is dedicated not only for Indonesian scholars who concern about educational studies, but also welcome to the scholars of Southeast Asian countries and around the world who care and share related to the educational studies in general. The MIMBAR PENDIDIKAN journal is published twice a year i.e. every March and September.Bandung, Indonesia: September 30, 2019 Andi Suwirta, M.Hum.Managing Editor of MIMBAR PENDIDIKAN Journal; and Senior Lecturer at the Department of History Education, Faculty of Social Studies Education UPI, Indonesia University of Education, in Bandung, West Java, Indonesia.
SEKOLAH DAN PENDIDIKAN KARAKTER ISLAMI (Sebuah Analisis Konseptual)
Authors: Ramin Ramin 
Published: October 2021

Abstract. The problem of the nation’s character until now and even in the future remains an interesting discussion for practitioners and observers. Thinking about the right formula to educate the character of the young generation as the nation’s successors is baing more focused in this country now. The busyness of parents, social environment, community, and social media have a role in shaping adolescent behavior. Adolescents are frequently affected to take actions that reflect bad character. This article is the result of deep thinking with the literature review method on the importance of schools taking a role in educating adolescent characters from references that specifically discuss the theories of character education models. School is a formal institution that possibly changes the role of the family in transferring good character values to students through the form of intra-curricular, co-curricular, extra-curricular, and habituation activities. The end of this article recommends that stakeholders should conceptually know well about the design, model, and character education approach that will be applied. Abstrak. Masalah karakter bangsa hingga saat ini dan bahkan ke depan masih tetap menjadi diskusi yang menarik bagi praktisi dan pemerhati. Memikirkan formula yang tepat untuk mendidik karakter generasi muda sebagai penerus bangsa adalah fokus yang lebih mengemuka di tanah air ini. Kesibukan orang tua, lingkungan sosial, komunitas, dan termasuk media sosial memiliki andil dalam membentuk perilaku remaja. Tak jarang para remaja terpengaruh, hingga melakukan tindakan-tindakan yang mencerminkan karakter yang buruk. Artikel ini merupakan hasil pemikiran mendalam dengan metode literatur review mengenai pentingnya sekolah mengambil peran dalam mendidik karakter remaja dari referensi yang khusus membahas tentang teori-teori model pendidikan karakter. Sekolah adalah organisasi formal yang sangat memungkinkan mengganti peran keluarga dalam mentransfer nilai-nilai karakter yang baik kepada siswa melalui bentuk kegiatan intra kurikuler, ko-kurikuler, ekstra kurikuler, maupun pembiasaan. Akhir dari artikel ini merekomendasikan bahwa stakehorders harus matang secara konseptual mengenai desain, model, dan pendekatan pendidikan karakter yang akan diaplikasikan.