bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Proteomic Analysis Reveals Novel Biomarkers for Gastric
Cancer in South Indian Tamil Population
Authors: Jayaraman Megala , Sivagnanam Ananthi , Thangasamy Balasankar , Nagarajan Vignesh , Ravi Subeksha Govindarajan , Madhesh Jeevitha Chithra , Perumal Manikandan Athilinga , Karunakaran Premkumar 
Published: June 2021

Background:
Gastric Cancer (GC) remains a major global health problem due to a poor
understanding of its progression at the molecular level and a lack of early detection or diagnosis.
Early detection is highly crucial for improving prognosis. The incidence of GC is very high in
countries, like India, due to the limitations among the established biomarkers for GC owing to poor
sensitivity and specificity.

Objective:
This study aimed to identify the novel biomarkers from serum samples obtained from
GC patients compared to healthy subjects.

Methods:
Serum samples from GC patients were analyzed by two-Dimensional Gel Electrophoresis
(2DGE) coupled with tandem Mass Spectrometry (MS), including both Matrix-Assisted Laser
Desorption/Ionization-Time of Flight (MALDI-ToF) and Liquid Chromatography-MS (LC-MS/MS)
analysis. Identified proteins were further analyzed by gene ontology and protein interaction studies.

Results:
A total of 73 protein spots were detected in 2DGE image analysis. Among them, seven
differentially-expressed proteins were identified using MS analyses, including serotransferrin/
transferrin, albumin, ceruloplasmin, C-reactive protein (CRP), fibrinogen γ-chain (FGG), and two
unreported novel proteins, immunoglobulin kappa constant (IgκC) region and Homo sapiens zinc
finger protein 28 (ZNF28) homolog. Among these proteins, serotransferrin, albumin,
ceruloplasmin, FGG, and ZNF28 were down-regulated in GC samples (p<0.05), while IgκC region
and CRP were up-regulated significantly.

Conclusion:
Most of the differentially expressed proteins were involved in angiogenesis,
plasminogen-activating cascade, and blood coagulation pathways which are known to play a
critical role in gastric tumorigenesis. Our current results provide a panel of candidate biomarkers
for GC with novel biomarkers which have not been reported earlier.
An Autophagy-related Long Non-coding RNA Signature for Breast
Cancer
Authors: Wang Jimei , Jiang Feng , Wu Chuyan , Wang Ming , Wei Ke 
Published: June 2021

Background:
The most prevalent malignant tumor in women is breast cancer (BC). As
autophagic therapies have been identified to contribute to BC cell death, the potential prognostic
role of long non-coding RNA (lncRNA) related to autophagy in patients with BC was examined.

Methods:
The lncRNAs expression profiles were derived from The Cancer Genome Atlas (TCGA)
database. Throughout univariate Cox regression and multivariate Cox regression test, lncRNA with
BC prognosis have been differentially presented. We then defined the optimal cut-off point
between high and low-risk groups. The receiver operating characteristic (ROC) curves were drawn
to test this signature. In order to examine possible signaling mechanisms linked to these lncRNAs,
the Gene Set Enrichment Analysis (GSEA) has been carried out.

Results:
Based on the lncRNA expression profiles for BC, a 9 lncRNA signature associated with
autophagy was developed. The optimal cut-off value for high-risk and low-risk groups was used.
The high-risk group had less survival time than the low-risk group. The result of this lncRNA
signature was highly sensitive and precise. GSEA study found that the gene sets have been greatly
enriched in many cancer pathways.

Conclusions:
Our signature of 9 lncRNAs related to autophagy has prognostic value for BC, and
these lncRNAs related to autophagy may play an important role in BC biology.
Withdrawal Notice: Identification of Potential Genes Associated with Vemurafenib Efficacy and Melanoma Prognosis
Authors: Qi Yue , Ma GuiE 
Published: June 2021

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn by mutual agreement between the editors and the publisher.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham Science Disclaimer:
It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously
submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere
must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting
the article for publication the authors agree that the publishers have the legal right to take appropriate action against the
authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright
of their article is transferred to the publishers if and when the article is accepted for publication.
Efficacy of Cavern Isolates for Biodegradation of Synthetic Plastic
Authors: Tabassum Jamila , Luqman Muhammad , Hasan Fariha , Arooj Fariha , Kashif Saif Ur Rehman , Yousafzai Asma 
Published: June 2021

Abstract:
Synthetic plastic waste management is a tenacious environmental concern at global level.
Although all types of synthetic plastics are a nuisance to the environment, however, versatility and one
time use has made polyethylene (PE) a foremost environmental issue. Current study has investigated
cavern bacterial strains isolated from PE samples from San Giovanni cave, Sardinia, Italy for their
efficacy to biodegrade low density polyethylene (LDPE) film. It was an initial effort to use cavern
bacteria in plastic biodegradation studies. Chemical and physical changes in the composition of LDPE
were studied by Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy
(SEM) after incubation with the bacterial consortium for two months. Collected cavern PE plastic
samples were also studied for biodegradation after incubation in nutrient broth for two months. FTIR
revealed obvious signs of degradation with the appearance of two new peaks of functional groups,
nitriles (C≡N) and amines (N-H) in LDPE film, which are intermediate metabolites of β-oxidation
pathway. An increase in various existing peaks of several intermediate metabolites, including
aldehydes, ketones, alcohols, and carboxylic acids, were also observed in experimental LDPE
compared to control. Peaks of alkanes decreased significantly owing to cavern bacterial activity. SEM
revealed biofilm formation on experimental LDPE surface with substantial mechanical damage.
Similar signs of degradation were observed in the cavern PE samples. Four bacterial strains in the
current consortium including Bacillus sonorensis, Bacillus subtilis, Aneurinibacillus spp., and
Alcaligenes faecalis are first time reported to be linked with biodegradation of plastics. The cavern
bacteria under study have the potential to biodegrade LDPE.
Evaluating Community-Facing Virtual Modalities to Support Complex Neurological Populations During the COVID-19 Pandemic: Protocol for a Mixed Methods Study
Authors: Brehon Katelyn , Carriere Jay , Churchill Katie , Loyola-Sanchez Adalberto , O'Connell Petra , Papathanassoglou Elisavet , MacIsaac Rob , Tavakoli Mahdi , Ho Chester , Pohar Manhas Kiran 
Published: June 2021

Background
The COVID-19 pandemic and concomitant governmental responses have created the need for innovative and collaborative approaches to deliver services, especially for populations that have been inequitably affected. In Alberta, Canada, two novel approaches were created in Spring 2020 to remotely support patients with complex neurological conditions and rehabilitation needs. The first approach is a telehealth service that provides wayfinding and self-management advice to Albertans with physical concerns related to existing neurological or musculoskeletal conditions or post-COVID-19 recovery needs. The second approach is a webinar series aimed at supporting self-management and social connectedness of individuals living with spinal cord injury.

Objective
The study aims to evaluate the short- and long-term impacts and sustainability of two virtual modalities (telehealth initiative called Rehabilitation Advice Line [RAL] and webinar series called Alberta Spinal Cord Injury Community Interactive Learning Seminars [AB-SCILS]) aimed at advancing self-management, connectedness, and rehabilitation needs during the COVID-19 pandemic and beyond.

Methods
We will use a mixed-methods evaluation approach. Evaluation of the approaches will include one-on-one semistructured interviews and surveys. The evaluation of the telehealth initiative will include secondary data analyses and analysis of call data using artificial intelligence. The evaluation of the webinar series will include analysis of poll questions collected during the webinars and YouTube analytics data.

Results
The proposed study describes unique pandemic virtual modalities and our approaches to evaluating them to ensure effectiveness and sustainability. Implementing and evaluating these virtual modalities synchronously allows for the building of knowledge on the complementarity of these methods. At the time of submission, we have completed qualitative and quantitative data collection for the telehealth evaluation. For the webinar series, so far, we have distributed the evaluation survey following three webinars and have conducted five attendee interviews.

Conclusions
Understanding the impact and sustainability of the proposed telehealth modalities is important. The results of the evaluation will provide data that can be actioned and serve to improve other telehealth modalities in the future, since health systems need this information to make decisions on resource allocation, especially in an uncertain pandemic climate. Evaluating the RAL and AB-SCILS to ensure their effectiveness demonstrates that Alberta Health Services and the health system care about ensuring the best practice even after a shift to primarily virtual care.

International Registered Report Identifier (IRRID)
DERR1-10.2196/28267
Ambulatory Risk Models for the Long-Term Prevention of Sepsis: Retrospective Study
Authors: Lee Jewel Y , Molani Sevda , Fang Chen , Jade Kathleen , O'Mahony D Shane , Kornilov Sergey A , Mico Lindsay T , Hadlock Jennifer J 
Published: June 2021

Background
Sepsis is a life-threatening condition that can rapidly lead to organ damage and death. Existing risk scores predict outcomes for patients who have already become acutely ill.

Objective
We aimed to develop a model for identifying patients at risk of getting sepsis within 2 years in order to support the reduction of sepsis morbidity and mortality.

Methods
Machine learning was applied to 2,683,049 electronic health records (EHRs) with over 64 million encounters across five states to develop models for predicting a patient’s risk of getting sepsis within 2 years. Features were selected to be easily obtainable from a patient’s chart in real time during ambulatory encounters.

Results
The models showed consistent prediction scores, with the highest area under the receiver operating characteristic curve of 0.82 and a positive likelihood ratio of 2.9 achieved with gradient boosting on all features combined. Predictive features included age, sex, ethnicity, average ambulatory heart rate, standard deviation of BMI, and the number of prior medical conditions and procedures. The findings identified both known and potential new risk factors for long-term sepsis. Model variations also illustrated trade-offs between incrementally higher accuracy, implementability, and interpretability.

Conclusions
Accurate implementable models were developed to predict the 2-year risk of sepsis, using EHR data that is easy to obtain from ambulatory encounters. These results help advance the understanding of sepsis and provide a foundation for future trials of risk-informed preventive care.
Renin-Angiotensin System Blockers and the Risk of COVID-19–Related Mortality in Patients with Kidney Failure
Authors: Soler Maria Jose , Noordzij Marlies , Abramowicz Daniel , de Arriba Gabriel , Basile Carlo , van Buren Marjolijn , Covic Adrian , Crespo Marta , Duivenvoorden Raphaël , Massy Ziad A. , Ortiz Alberto , Sanchez J. Emilio , Petridou Emily , Stevens Kate , White Colin , Vart Priya , Gansevoort Ron T. ,   the ERACODA Collaborators
Published: June 2021

Background and objectives
There is concern about potential deleterious effects of angiotensin-converting enzyme inhibitors (ACEis) and angiotensin II receptor blockers (ARBs) in patients with coronavirus disease 2019 (COVID-19). Patients with kidney failure, who often use ACEis/ARBs, are at higher risk of more severe COVID-19. However, there are no data available on the association of ACEi/ARB use with COVID-19 severity in this population.

Design, setting, participants, & measurements
From the European Renal Association COVID-19 database (ERACODA), we retrieved data on kidney transplant recipients and patients on dialysis who were affected by COVID-19, between February 1 and October 1, 2020, and had information on 28-day mortality. We used Cox proportional-hazards regression to calculate hazard ratios for the association between ACEi/ARB use and 28-day mortality risk. Additionally, we studied the association of discontinuation of these agents with 28-day mortality.

Results
We evaluated 1511 patients: 459 kidney transplant recipients and 1052 patients on dialysis. At diagnosis of COVID-19, 189 (41%) of the transplant recipients and 288 (27%) of the patients on dialysis were on ACEis/ARBs. A total of 88 (19%) transplant recipients and 244 (23%) patients on dialysis died within 28 days of initial presentation. In both groups of patients, there was no association between ACEi/ARB use and 28-day mortality in both crude and adjusted models (in transplant recipients, adjusted hazard ratio, 1.12; 95% confidence interval [95% CI], 0.69 to 1.83; in patients on dialysis, adjusted hazard ratio, 1.04; 95% CI, 0.73 to 1.47). Among transplant recipients, ACEi/ARB discontinuation was associated with a higher mortality risk after adjustment for demographics and comorbidities, but the association was no longer statistically significant after adjustment for severity of COVID-19 (adjusted hazard ratio, 1.36; 95% CI, 0.40 to 4.58). Among patients on dialysis, ACEi/ARB discontinuation was not associated with mortality in any model. We obtained similar results across subgroups when ACEis and ARBs were studied separately, and when other outcomes for severity of COVID-19 were studied, e.g., hospital admission, admission to the intensive care unit, or need for ventilator support.

Conclusions
Among kidney transplant recipients and patients on dialysis with COVID-19, there was no significant association of ACEi/ARB use or discontinuation with mortality.
JULO-JULO TANI BURUH PEREMPUAN JORONG PATAMUAN, NAGARI TALU KECAMATAN TALAMU KAB. PASAMAN BARAT
Authors: Wahyuni Sri , Zusmelia Zusmelia , Syafrini Delmira 
Published: June 2021

This resereach explain about of julo- julo tani of women peasant life in Jorong Patamuan, they works to help her families economic. This research aims to see Julo Julo cause of the peasantry in public life and social economic impact of Julo Julo tani women peasent worker in Jorong Patomuan Nagari Talu Talamau of Pasaman Barat. This study used a qualitative approach with methods such as observation and interviews. Informants in this study more or less 16 peoples. Results were analyzed using the theory of George Homans, who showing human behavior as individual behavior, where people are exchanging rewards or punishment. Based on the results of this study concluded causative factor the rise of julo-julo in women peasent life in Jorong Patamuan such as 1), Economic conditions 2), less of the capital 3), Solidarity relations people who are less well 4), to Supporting the community's economy. So with Julo Julo tani due to their desire to make a group, to help difficulties of life, and to improve solidarity of them.Julo-julo tani dalam kehidupan buruh tani perempuan Jorong Patomuan, yang bekerja untuk meringankan pemenuhan kebutuhan ekonomi keluarga. Peneitian ini bertujuan untuk melihat fakotor penyebab munculnya julo-julo tani dalam kehidupan masyarakat buruh tani perempuan dan dampak julo-julo tani terhadap kehidupan sosial dan ekonomi masyarakat buruh tani perempuan Jorong Patomuan Nagari Talu Kecamatan Talamau Kabupaten Pasaman Barat. Penelitian ini menggunakan pendekatan kualitatif dengan metode yaitu observasi dan wawancara. Jumlah informan 16 orang. Hasil penelitian dianalisis menggunakan teori George Homans yang memperlihatkan perilaku manusia sebagai perilaku individu, tempat orang-orang yang saling bertukar ganjaran atau hadiah. Berdasarkan hasil penelitian dapat disimpulkan bahwa faktor penyebab munculnya julo-julo dalam kehidupan buruh tani perempuan di Jorong Patomuan adalah 1). Keadan Ekonomi, 2). Kurangnya Modal, 3). Hubungan Solidaritas masyarakat yang kurang baik, 4). Penunjang perekonomian masyarakat. Sehingga dengan julo-julo tani disebabkan dengan adanya keinginan untuk membentuk kelompok atau (group) yang dpat mengatasi kesulitan mereka dalam kehidupan sehari-hari. Sekaligus meningkatkan kembali solidaritas mereka.
STRATEGI MASYARAKAT MULTIKULTURAL PASAMAN BARAT MENGHINDARI KONFLIK
Authors: Debora Elly Kristin , Anggreta Dian Kurnia , Yasin Faishal 
Published: June 2021

Nagari Koto Baru Kecamatan Luhak Nan Duo Kabupaten Pasaman Barat Sumatera Barat, a district with multicultural society, consists of many ethnics which have different cultural each other’s. Despite of many ethnics in Nagari Koto Baru, it doesn’t make any conflicts occurred. This research using qualitative method (questionnaires and interviews) and focused to the reasons and strategies of people in Koto Baru to avoid conflicts in their societies. The results showed that why people in Nagari Koto Baru avoid conflicts cause of solidarity and marriage factors. In the manner of marriage, people become closer and higher solidarity among many ethnics. And the strategies to avoid conflicts by means of cooperation, accommodation and assimilation. Cooperation many ethnics, accommodation (the efforts to solve conflicts) and assimilation (by marriage among many ethnics) are appropriate strategies to avoid conflicts Masyarakat Nagari Koto Baru adalah masyarakat yang multikultural yang terdiri dari berbagai suku bangsa, dimana setiap suku bangsa memiliki kebudayaaan yang berbeda.Meskipun masyarakat nagari Koto Baru memiliki keanekaragaman suku bangsa, namun di Nagari Koto Baru tidak pernah terjadi konflik. Dalam penelitian ini yang akan diteliti adalah apa penyebab dan bagaimana strategi masyarakat multikultural di Nagari Koto Baru di Kecamatan Luhak Nan Duo Kabupaten Pasaman Barat menghindari konflik. Penyebab masyarakat multikultural di Nagari Koto Baru di Kecamatan Luhak Nan Duo Kabupaten Pasaman Barat menghindari konflik disebabkan oleh dua faktor yaitu faktor solidaritas dan faktor perkawinan. Solidaritas yang terbangun diantara berbagai suku meminimalkan kemungkinan terjadinya konflik. Dengan perkawinan, juga merupakan salah satu cara terhindar dari konflik. Sementara itu, strategi yang dilakukan oleh masyarakat Nagari Koto Baru dalam menghindari konflik adalah dengan cara melakukan suatu proses kerjasama, akomodasi dan asimilasi. Akomodasi yang merupakan upaya damai untuk mencapai penyelesaian dari suatu pertikaian dan asimilasi dengan jalan melakukan perkawinan antar sukubangsa yang satu dengan yang lain, disamping meningkatkan kerjasama, menjadi strategi yang jitu bagi masyarakat Nagari Koto Baru untuk menghindari konflik.
DIAMIKA PEREMPUAN PEDAGANG MAKANAN DI SICINCIN
Authors: Roza Elsa Melia , Yulkardi Yulkardi , Fitlayeni Rinel 
Published: June 2021

This article discusses the activities of women food vendors in Nagari Sicincin, women's involvement has keterbartasan informal sector to resources and access. As a result, business options that can be entered also ranges in some specific fields such as trade food hawkers. Women asongan food traders in carrying out its activities he had to leave the family in a period of 9-10 hours a day. Before going home or going to work, he must do homework at the same time, This article aims to describe the activities of women food vendors hawkers around Station Sicincin. and analyze the constraints experienced by women hawkers hawkers in work. The method used qualitative descriptive type, The data collection is done by observation, interview and documentation study, The findings of this article, namely the allocation of time, that work outside the home as a trader of food hawkers, conducted from 08.00 am until 17:00 pm, Competition and conflict. Tip mastery of the market situation, that take advantage of the holiday, shoppers want visited by giving discounts to buyers, already terbntuknya image salted egg and boiled bananas. and the constraints faced by women food vendors hawkers are obstacles in the work, namely the driver and passenger Bus unfriendly, and the absence of gas stations.Artikel ini membahas aktifitas perempuan pedagang makanan di Nagari Sicincin, keterlibatan perempuan disektor informal memiliki keterbartasan terhadap sumber daya dan akses. Akibatnya pilihan usaha yang dapat dimasuki juga berkisar pada beberapa bidang tertentu seperti berdagang makanan asongan. Perempuan pedagang makanan asongan dalam menjalankan aktivitasnya ia harus meninggalkan keluarga dalam jangka waktu 9-10 jam dalam sehari. Sebelum pulang ataupun berangkat kerja, ia harus mengerjakan pekerjaan rumah sekaligus. Artikel ini bertujuan untuk mendeskripsiakn aktivitas perempuan pedagang mkanan asongan di sekitar Terminal Sicincin, dan menganalisis kendala-kendala yang dialami oleh prempuan pejaja makanan asongan dalam pekerjaan. Metode yang digunakan kualitatif dengan tipe penelitian deskriptif. Pengumpulan data dilakukan dengan cara observasi, wawancara, dan studi dokumentasi. Temuan dari artikel ini yaitu alokasi waktu, yaitu pekerjaan diluar rumah sebagai pedagang makanan asongan, dilakukan dari jam 08.00 WIB sampai jam 17.00 WIB. Persaingan, dan konflik. Kiat penguasaan situasi pasar, yaitu memanfaatkan hari libur, pembeli ingin didatangi memberikan potongan harga bagi pembeli, sudah terbntuknya image telur asin dan pisang jantan rebus. dan kendala-kendala yang dialami perempuan pedagang makanan asongan adalah kendala dalam pekerjaan, yaitu supir dan penumpang Bus tidak bersahabat, dan ketiadaan SPBU..