bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological Outcomes in Children and Early Adolescents With Type 1 Diabetes Following Pediatric Diabetes Summer Camp: A 3-Month Follow-Up Study
Authors: Troncone Alda , Chianese Antonietta , Cascella Crescenzo , Zanfardino Angela , Iafusco Dario 
Published: March 2021

Objective:The aim of this study was to assess general psychosocial adjustment to diabetes and perceived disease management among patients with type 1 diabetes (T1D) and their parents before and after patients' participation in a diabetes summer camp.Methods:In this follow-up study, 20 children and adolescents with T1D (eight boys; mean age = 11.01 ± 0.94 years; mean diabetes duration = 3.02 ± 2.27) attending a southern Italian diabetic center, along with their parents, were assessed prior to and 3 months after the youths participated in a 1 week camp-based intervention involving didactic and interactive child-centered education and recreational activities. Patients and their parents completed measures assessing patients' quality of life and strategies employed by patients to cope with pain. Patients also completed measures evaluating their diabetes psychosocial adjustment, diabetes self-efficacy management, and illness perception; also, their parents completed measures of caregivers' perceived diabetes burden and treatment satisfaction. Youths' glycated hemoglobin (HbA1c) and standardized body mass index (z-BMI) values were also assessed. Within-subjects repeated-measures analyses of variance evaluated pre- and post-camp changes.Results:Camp attendance showed no beneficial effects on glycemic control, as indicated by HbA1c values both before (7.02%) and after (7.28%) camp being lower than 7.5%. HbA1c values were found to have increased after camp (pre-camp = 7.02%, post-camp = 7.28%;p= 0.010), but since they still fell within an acceptable range, they did not reveal clinically relevant changes in glycemic control. No substantial significant improvement in psychosocial measures was observed in children or parents (allp&gt; 0.05). According to the parents' evaluation, social support-seeking as a patient pain-coping strategy was slightly increased (p= 0.044) after attending the camp.Conclusions:This study does not provide empirical evidence of benefits of participating in a diabetes camp for either patients or their parents. These findings suggest that healthcare providers rethink such camps as an experience for youths with T1D that actively involves parents and that includes both youth- and parent-focused psychological interventions.
The Punicalagin Metabolites Ellagic Acid and Urolithin A Exert Different Strengthening and Anti-Inflammatory Effects on Tight Junction-Mediated Intestinal Barrier Function In Vitro
Authors: Hering Nina A. , Luettig Julia , Jebautzke Britta , Schulzke Jörg D. , Rosenthal Rita 
Published: March 2021

Scope: Ellagitannins are polyphenols found in numerous fruits, nuts and seeds. The elagitannin punicalagin and its bioactive metabolites ellagic acid and urolithins are discussed to comprise a high potential for therapeutically or preventive medical application such as in intestinal diseases. The present study characterizes effects of punicalagin, ellagic acid and urolithin A on intestinal barrier function in the absence or presence of the proinflammatory cytokine tumor necrosis factor-α (TNFα).Methods and Results: Transepithelial resistance (TER), fluorescein and ion permeability, tight junction protein expression and signalling pathways were examined in Caco-2 and HT-29/B6 intestinal epithelial cell models. Punicalagin had less or no effects on barrier function in both cell models. Ellagic acid was most effective in ileum-like Caco-2 cells, where it increased TER and reduced fluorescein and sodium permeabilities. This was paralleled by myosin light chain kinase two mediated expression down-regulation of claudin-4, -7 and -15. Urolithin A impeded the TNFα-induced barrier loss by inhibition of claudin-1 and -2 protein expression upregulation and claudin-1 delocalization in HT-29/B6.Conclusion: Ellagic acid and urolithin A affect intestinal barrier function in distinct ways. Ellagic acid acts preventive by strengthening the barrier per se, while urolithin A protects against inflammation-induced barrier dysfunction.
Catalpol Protects Against High Glucose-Induced Bone Loss by Regulating Osteoblast Function
Authors: Zhao Lu , Du Wei , Zhao Dandan , Ji Xueyan , Huang Yanfei , Pang Yong , Guo Kaijin , Yin Xiaoxing 
Published: March 2021

Objective: The overall objective of this study was to investigate the effects of catalpol on bone remodeling of diabetic osteoporosis by regulating osteoblast differentiation and migration.Method: Using a murine model of diabetic osteoporosis, to detect the protective effects of catalpol on bone loss, architectural deterioration of trabecular bone and bone metabolism biomarkers were tested. A model of MC3T3-E1 cells was established by treatment with high glucose; the regulatory role of catalpol in the differentiation and migration was tested by Western blot, ALP staining, and Alizarin Red staining.Results: Catalpol treatment markedly ameliorated trabecular bone deterioration by reducing degenerative changes of the trabecular structure by improving the bone formation marker levels of ALP, osteopontin, type I collagen, and osteocalcin, as well as the level of OPG/RANKL. Catalpol enhanced cell motility and scattering following gap formation of MC3T3-E1 cells.Conclusion: The results indicated that catalpol exhibits a protective effect against diabetic osteoporosis by regulating the differentiation and migration of osteoblast.
Impact of Low Hemoglobin on Body Composition, Strength, and Redox Status of Older Hemodialysis Patients Following Resistance Training
Authors: da Silva Victor , Corrêa Hugo , Neves Rodrigo , Deus Lysleine , Reis Andrea , Souza Michel , dos Santos Cláudio , de Castro Danilo , Honorato Fernando , Simões Herbert , Moraes Milton , Schoenfeld Brad , Prestes Jonato , Rosa Thiago 
Published: March 2021

IntroductionThe purpose of this study was to: (i) investigate the effect of six months of resistance training (RT) on body composition, muscle strength, hematological patterns, and redox profile in maintenance hemodialysis (HD) patients, and; (ii) evaluate the effects of baseline concentrations of hemoglobin on the RT response.MethodsOne hundred fifty-seven subjects with chronic kidney disease (CKD) were randomly allocated into two groups: Control [CTL, (n= 76)] and RT (n= 81). A first visit was required for anamnesis and anthropometric measurements. Venous blood samples were collected at baseline and after twenty-four weeks of training in all patients for the analysis of clinical and redox balance markers. The RT program spanned six months and consisted of three sets of 8–12 repetitions with a rating of perceived exertion between 5 and 8 for three weekly sessions. Each exercise session was performed in twelve resistance exercises and it least for approximately 40 min.ResultsThe main results demonstrated that RT decreased waist circumference by 3%, and decreased thiobarbituric reactive species (TBARS) by 28%. Moreover, RT increased handgrip strength by 28.4%, fat-free mass by 4.1%, hemoglobin by 5%, iron by 33.4%, glutathione by 121%, and Trolox equivalent antioxidant capacity by 14.2% (p&lt; 0.05). Low hemoglobin concentrations impaired the effect of RT on fat-free mass gain.ConclusionSix months of RT in HD patients improved clinical parameters, such as hemoglobin, iron, body composition, and redox balance, while low hemoglobin concentration impaired exercise-benefits on fat-free mass in patients with CKD. These findings can contribute to a better clinical application of RT in the maintenance of hemodialysis patients.
Social Support and Hope Mediate the Relationship Between Gratitude and Depression Among Front-Line Medical Staff During the Pandemic of COVID-19
Authors: Feng Lijuan , Yin Rong 
Published: March 2021

BackgroundThe pandemic of Coronavirus Disease 2019 (COVID-19) has burdened an unprecedented psychological stress on the front-line medical staff, who are at high risk of depression. While existing studies and theories suggest that factors such as gratitude, social support, and hope play a role in the risk of depression, few studies have combined these factors to explore the relationship between them.ObjectiveThis study examined the mediating roles of social support and hope in the relationship between gratitude and depression among front-line medical staff during the pandemic of COVID-19.MethodsThis study used the Gratitude Questionnaire, the Perceived Social Support Scale (PSSS), the State Hope Scale (SHS), and the Center for Epidemiologic Studies Depression Scale to examine the gratitude, social support, hope, and depression among 344 front-line medical workers in Wuhan, which was the hardest-hit area of COVID-19 in China.ResultsThe results showed that the prevalence of mild depressive disorder was 40.12% and the prevalence of major depressive disorder was 9.59% among front-line medical staff during the pandemic of COVID-19; gratitude has a direct and negative effect on depression. Gratitude was negative predictors of depression through the mediating variables of social support and hope [βgratitude–social support–depression = −0.096, 95%CI(−0.129 to −0.064); βgratitude–hope–depression = −0.034, 95%CI(−0.055 to −0.013)], as well as via an indirect path from social support to hope [βgratitude–social support–hope–depression = −0.089, 95%CI (−0.108 to −0.070)].ConclusionThe study findings indicate that gratitude as a positive emotion can reduce depression in medical staff by promoting social support and hope, respectively. Gratitude also reduced depression in health care workers through a chain mediating effect of social support and hope. Overall, gratitude can directly foster social support and hope, and protect people from stress and depression, which has implications for clinical interventions among front-line medical staff during the pandemic of COVID-19.
Expression of Dopamine D1−4 and Serotonin 5-HT1A-3A Receptors in Blood Mononuclear Cells in Schizophrenia
Authors: Wysokiński Adam , Kozłowska Elżbieta , Szczepocka Ewa , Łucka Anna , Agier Justyna , Brzezińska-Błaszczyk Ewa , Sobierajska Katarzyna 
Published: March 2021

Introduction: The aim of this study was to determine the mRNA expression profile of dopamine D1, D2, D3, D4 and serotonin 5-HT1A, 5-HT2A, and 5-HT3A receptors in peripheral blood mononuclear cells (PBMCs) in schizophrenia and the in vitro effect of antipsychotics on the expression of these receptors in PBMCs of healthy subjects.Materials and Methods: Twenty-seven patients with schizophrenia and 29 healthy controls were recruited for the study. All study subjects underwent thorough clinical assessment, including anthropometric and body composition measurements. The expression of mRNA for dopamine D1−4 and serotonin 5-HT1A−3A receptors was measured using quantitative RT-PCR in peripheral blood mononuclear cells. In vitro mRNA and protein expression of these receptors was measured using quantitative RT-PCR and Western Blotting in PBMCs cultured with quetiapine, haloperidol, aripiprazole, risperidone, olanzapine or clozapine at IC50, half of IC50, and one-quarter of IC50 concentrations.Results: The key finding was that the schizophrenia group demonstrated significantly higher mRNA expression of D1, D2 and D4 receptors (p &lt; 0.001), and significantly lower mRNA expression of 5-HT3A receptors (p &lt; 0.01). After adjusting for smoking, the mRNA expression of D1 lost its significance, while that of D3, 5-HT1A, 5-HT2A became significant (all three were lower in the schizophrenia group). These receptors also demonstrated different ratios of mRNA expression in the schizophrenia group. The in vitro experiments showed that high concentrations of antipsychotics influenced the mRNA and protein expression of all studied receptors.Conclusion: Schizophrenia patients display a distinctive pattern of dopamine and serotonin receptor mRNA expression in blood mononuclear cells. This expression is little affected by antipsychotic treatment and it may therefore serve as a useful diagnostic biomarker for schizophrenia.
ANALISIS TOTAL FENOL PADA BERBAGAI FORMULASI REBUSAN KULIT SALAK BALI SIBETAN KARANGASEM SEBAGAI MINUMAN FUNGSIONAL
Authors: Merta Wayan 
Published: March 2021

Abstract
Background: Snakefruit’s bark that only so far as waste, can be processed into a functional beverage is good for health. Snakefruit’s bark contains phenolic compounds which are natural antioxidants in fruits. Objective: The purpose of this study is to determine the total phenol levels and sensory value of stew salak bali sibetan karangasem’s bark in various formulations as functional beverage. Methods: Analysis of total used spectrophotometric method with Folin-Ciocalteu phenol reagent and gallic acid standard. It also performed the water content analysis used thermogravimetry method. Result: Salak Bali Sibetan’s bark have average water content 24.1872±0.036%wb. The results of total phenol analysis showed that 2, 10, 20, 30, 40 gram of Salak Bali’s bark with 200 ml water are: 10,84±0,587; 13,79±0,756; 12,19±0,205; 12,02±0,268; 10,57±0,389 mg/L GAE respectirely. Conclusions: The highest total phenol content is (10g/200ml) formulation, and also supported by a sensory test showed that a majority of panelist also prefer that formulation because has good colour, flavor and smell.

Keywords : Salak Bali’s Sibetan bark, total phenol, Folin-Ciocalteu.
GAMBARAN KADAR GLUKOSA DARAH PUASA PADA IBU HAMIL TRIMESTER II DAN III DI PUSKESMAS I DENPASAR SELATAN
Authors: Putri Dhyana 
Published: March 2021

AbstractBackground Gestational diabetes mellitus (GDM) was a condition of glucose intolerance that occur during pregnancy detected by examining blood glucose levels. Objective This study aims to measure fasting blood glucose levels at the second and third trimesters pregnant women in Puskesmas I Denpasar Selatan-based on certain characteristics. Methods The type of this study is descriptive and using simple random sampling technique. Samples in this study amounted to 33 women. Blood glucose levels measured by venous blood samples with hexokinase method. Result The study results obtained 28 women (84,85%) in the not risk of GDM category and five women (15,15%) in the risk of GDM category. High blood glucose levels obtained four women (12,12%) in the category 25 years and one women (3,03%) in the category 25, on the characteristics of the gestational age obtain two women (6,06%) in the second trimester and three women (9,09%) in the third trimester, on the characteristics of DM in the family obtained one women (3,03%) with a history of DM.Conclusion The conclusion of this research obtained fasting blood glucose level in trimester II and III pregnant women at Puskesmas I Denpasar Selatan ranged between 66 - 120 mg/dL. Keywords: blood glucose, pregnant women, gestational diabetes
PENGARUH VARIASI SUHU PENYIMPANAN TERHADAP VITALITAS SPERMA
Authors: Merta I Wayan 
Published: March 2021

Background. Sperm is very sensitive to changes in temperature, this can cause changing the characteristics of spermatozoa. To perform sperm analysis it is necessary to determine the optimal storage temperature to keep the characteristic of sperm samples remain representative.Objective. The purpose of this study to determine the effect of variation in storage temperature on sperm vitality, in order to determine the optimal storage temperature of sperm samples when delay of examination.Methods. In this study we used microscopic method with supravitalstainting using 0,5% eosin staint. Dead spermatozoa will be stained by eosin and live spermatozoa will not be stained by eosin.The study was conducted on 8 subject of the Department of Health Analyst Poltekkes Denpasar that selected by randomly simpling with One Group pretest-posttest design. The measured variable is the value of sperm vitality before and after treatment.Results : Analysis with T-Paired test showed significant difference before and after treatment (p 0,05) before treatment 84,687% ± 3,796, to 78.725% ± 3.809 at 4oC, at temperature 25oC is 82,7875 % ± 3,588, and at 37°C is 70% ± 4,152. Conclusion. From the results of research that has been done, it can be concluded that the decrease in sperm vitality is obtained at least 25oC storage temperature for 1 hour and the most decrease obtained at storage at 37oC for 1 hour. Keywords: Sperm vitality, spermatozoa
INFUSA DAUN JAMBU BIJI ( Psidium guajava L.) SEBAGAI BAHAN ANTIMIKROBA PADA RONGGA MULUT
Authors: Yani Siti Nur 
Published: March 2021

Abstract Background: Guava plants (Psidium guajava Linn) are found throughout Indonesia. The leaves contain tannins that can be exploited as antibacterial and antifungal. The presence of fungi and bacteria in the oral cavity can be a problem in oral and dental health.The purpose of this research is to know the infusa of guava leaf 10%, 20% to decrease the number of oral germs as wellMethods: The experimental study used 30 primary school children divided into 3 groups. Group 1 was taken saliva sample before and after gargle with 10% guava leaf infusa. Group 2 was taken saliva sample before and after rinsing with 20% guava leaf infusion, and for group 3 with brand X mouthwash. Saliva samples taken before and after rinsing with all three ingredients were then examined using the Total Plate Count method.The results showed that the numbers of germs before and after rinsing with 10% and 20% casque seed infections were significantly different (sig 0.001 and 0.000). The average difference between the 10% infusa and the X brand drug shows an un-coercive difference (sig 0.947).Conclusion Guava leaves infution 10% and 20% can decrease the number of oral germs. Both concentrations of guava leaf infution compared with X brand mouthwash have no significant difference in reducing germ numbers. Keywords: guava leaf infution, number of germs, oral cavity
Audiencia para el septentrión americano, suprimir o no la Audiencia de Guadalajara
Authors: Orozco Martin del Campo Alfredo José 
Published: March 2021

El presente trabajo analiza el porqué de la permanencia de la Real Audiencia y Chancillería de Guadalajara, en el Reino de Nueva Galicia a mediados del siglo XVII, después de que la corona se planteara suprimirla por la falta de trabajo y por lo costoso para la arcas, esto se debió a que se dieron una serie de incidentes que aceleraron y ameritaron una Visita y una serie de consultas a diversos funcionarios, que se decantaban por la supresión de la Audiencia, esto debido a la falta de “concordia” entre los funcionarios y la aparente falta de trabajo de estos, lo que provocó que se sometiera al Consejo de Indias, por lo que se planteó la permanencia o no de dicha institución, todo ello a partir de una serie de cartas, consultas y visitas contenidas en un expediente del Archivo General de Indias.
Precursores de la revolución mundial
Authors: Samaniego Marco Antonio 
Published: March 2021

En Regeneración, los anarquistas del Partido Liberal Mexicano, de 1911 a 1918, llamaron al proletariado estadounidense y europeo a realizar una revolución mundial que terminara con el capitalismo y toda forma de autoridad. Su pretensión era formar conscientes que expropiaran todos los medios de producción, por lo que permanecieron en Los Ángeles, California, donde tenían las condiciones para editar Regeneración y tener múltiples contactos con la prensa ácrata de Estados Unidos y Europa. Basados en la mencionada publicación, se demuestra que concibieron su actividad como parte de la lucha revolucionaria anarquista que ya había empezado en México y buscaron la ayuda de los trabajadores del mundo, tanto para que arribaran a nuestro país como para expandir las expropiaciones en el orbe.
Los anarquistas del Partido Liberal Mexicano (PLM) han sido analizados sólo como parte del proceso revolucionario en México. Desde ese ángulo se han conformado una serie de afirmaciones sobre su actuación, mismas que se han convertido en un espacio común acerca de sus intenciones revolucionarias. Sin embargo, no se aborda su llamado insistente a la revolución mundial, lo que obliga a una interpretación más compleja, que no se apega a las limitadas explicaciones que surgieron en la posrevolución.
Cost and Time Analysis of the Acceleration Earthworks with the Method of Adding Heavy Equipment to the Depok-Antasari Toll Road Project
Authors: Susanti Irriene Indah , Rimawan Fahmizan 
Published: March 2021

The development of Depok-Antasari Toll road construction was delayed by the work on the implementation of land work of 30.70% from the original plan presentation so that The initially planned time was completed in August 2019 extended to be completed in December 2019. In this study will analyze the acceleration of completion duration on The construction project of Depok–Antasari Toll road with an alternative to the number of heavy equipment. The purpose of this research is to know the cost of project that is physical and duration of time is faster by using the alternative. The results of the analysis was obtained that total project cost under normal conditions is IDR. 9,860,552,249.00 with the duration of project execution 130 working days. In the condition after accelerated with the addition of the number of heavy equipment alternative– 1 obtained a fee of Rp. 10,030,638,486.00 or more expensive 1.02% of the project cost in normal conditions and duration Project execution of 109 business days or faster 21 days from the normal duration. While the total cost of the project in the alternative condition–2 obtained Rp. 10,153,918,103.00 or more expensive 1.04% of the project cost under normal conditions and duration of project execution 104 days or faster 26 days from the normal duration. It can concluded that the acceleration of work by alternative method-1 is a more effective and economical acceleration alternative, because By applying an alternate acceleration–1. The duration of project work is faster than normal circumstances and does not experience a delay of employment from the planned time of 120 days. And the total budget cost of the project is cheaper compared to the alternative acceleration method-2.
Hacia una didáctica comprensivo edificadora
Authors: Arboleda Julio César 
Published: March 2021

A la luz de orientaciones tales como las pedagogías mesoaxiológica, de la alteridad, radical - inclusiva, y en particular la perspectiva comprensivo edificadora (PCE) de la educación y la formación que el autor ha venido proponiendo en la última década, este documento, de carácter crítico y propositivo, expone algunas deudas de la didáctica, atada a la soberbia de la racionalidad y el pensamiento moderno, así como ideas, conceptos y estratagemas para una didáctica otra que tenga al ser humano, la vida y la existencia como piedra angular y sentido que impulsa sus ocupaciones como dominio multisaber en torno a la enseñanza, la formación y los aprendizajes. De la misma manera se hace énfasis en algunos tratamientos críticos y discursivos, todos los cuales superan el carácter técnico, deóntico y ensimismado que pesa en la didáctica y en la educación por encima del precepto supremo de servir propósitos humanizantes, y que por efecto va más allá de visiones y constructos entregados a las lógicas y tecnicismos de enseñabilidad del saber. Algunas de las reconceptualizaciones, nociones y nuevos conceptos, inherentes a la PCE de la didáctica, la pedagogía y la educación, que tienen lugar a lo largo de la exposición, son, entre otros: didáctica, enseñar educando, enseñanza, comprensión, CE, PCE, calidad educativa, vida, proyectos de vida, humanización de la educación y de la didáctica, evaluación edificadora, alteridad ética, DCE, episteme comprensivo edificadora, lógicas sentientes, pausa didáctica, parto pedagógico formativo, ACE, ECE, desarrollo/evolución humano, comprensión ética, praxis formativa comprensiva, ótrico.