bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isthmus topography is a risk factor for persistent disease in patients with differentiated thyroid cancer
Authors: Campennì Alfredo , Ruggeri Rosaria Maddalena , Siracusa Massimiliano , Giacoppo Giulia , La Torre Flavia , Saccomanno Angiola , Alibrandi Angela , Dionigi Gianlorenzo , Tuccari Giovanni , Baldari Sergio , Giovanella Luca 
Published: July 2021

Aim
The risk of differentiated thyroid cancer (DTC) recurrence is widely evaluated according to the 2015 ATA Risk Stratification System. Topography of malignant nodules has been previously reported as an additional risk factor but is not included in the ATA system. Thus, our study aimed to evaluate the relationship between DTC topography and response to initial therapy.

Patients and methods:
We enrolled 401 low- to intermediate-risk patients with DTC who had undergone thyroidectomy and radioiodine therapy. DTC topography was recorded and compared with the response to therapy as assessed 12 months after the end of therapy.

Results
Overall, 366/401 (91.3%) patients had an excellent response to initial therapy while 22/401 (5.5%) and 13/401 (3.2%) had incomplete biochemical or structural responses, respectively. Incomplete response occurred in 10/36 (27.8%), 5/125 (4.0%), and 4/111 (3.6%) patients whose unifocal malignant nodules were located in the isthmus, right lobe, or left lobe. Incomplete response was also observed in 4/54 (7.4%) and 12/75 (16%) patients carrying multifocal cancers in one or both lobes, respectively. Patients with isthmic cancer more frequently demonstrated incomplete response compared with those who had cancer in other locations (P = 0.00). No significant relationship was found with age, gender, maximum size of malignant nodule, Hashimoto’s thyroiditis, vascular invasion, and extrathyroidal extension (P = 0.78, P = 0.77, P = 0.52, P = 0.19, P = 0.73, and P = 0.26, respectively). The risk of incomplete response was about 65% higher in patients with isthmic lesions compared with other patients (odds ratio = 6.725). A log-rank test demonstrated that disease-free survival (DFS) of patients with isthmic lesions was significantly shorter than that of other patients (P = 0.02).

Conclusion
Our data show that isthmus topography of malignant thyroid nodules is a risk factor for having both persistent disease 12 months after primary treatment and reduced DFS.
Sandra Soler. Mujeres músicas. Dificultades, avances y metas a alcanzar en el siglo XXI. Castellón: Publicacions de la Universitat Jaume I, 2019.
Authors: Saneleuterio Elia 
Published: July 2021

Mujeres músicas. Dificultades, avances y metas a alcanzar en el siglo XXI Autora: Sandra Soler.Castellón: Publicacions de la Universitat Jaume I, 2019.
Candidatas Guerreiras no Brasil: um estudo de caso das narrativas audiovisuais das mulheres mais votadas às prefeituras das capitais em 2020=Women warrior candidates in Brazil: a case study of the audiovisual narratives of the most voted women for capital city halls in 2020
Authors: Panke Luciana 
Published: July 2021

ResumoEsta investigación expone la estructura de un patrón de objetificación respecto al cuerpo Nas últimas eleições municipais brasileiras, apenas uma mulher foi eleita para governar uma capital, entre os 26 estados da federação. Este artigo apresenta o cenário eleitoral para, então, trazer análise das narrativas audiovisuais das três candidatas mais bem votadas naquele pleito: Cinthia Ribeiro (PSDB), eleita em Palmas (TO), região Norte, Manoela D’Ávila (PCdoB), no Sul, em Porto Alegre (RS) e Marilia Arraes (PT) em Recife (PE), Nordeste. Como metodologia aplicou-se a proposta de PANKE (2015, 2016, 2018) para identificar os arquétipos das candidaturas femininas: Guerreira, Maternal e Profissional. Como resultado, observou-se que os vídeos posicionaram as candidatas de maneira combativa. Ainda que houvesse a exibição também da maternidade nas três campanhas, a eleita foi quem exibiu equilíbrio entre arquétipos. AbstractThis investigation exposes the structure of a landlord of objectification with respect to the body. In the last Brazilian municipal elections, only one woman was elected to govern a capital, among the 26 states of the federation. This article presents the electoral scenario and analyzes the audiovisual narratives of the three best-voted candidates in that election: Cinthia Ribeiro (PSDB), elected in Palmas (TO), North region, Manoela D'Ávila (PCdoB), in the South, in Porto Alegre (RS) and Marilia Arraes (PT) in Recife (PE), Northeast. As a methodology, the proposal of PANKE (2015, 2016, 2018) was applied to identify the archetypes of female candidates: Warrior, Maternal and Professional. As a result, it was observed that the videos positioned the candidates in a combative way. Although there was also an exhibition of motherhood in the three campaigns, the elected was the one who exhibited balance between archetypes.
The formulation of nusantara fiqh in Indonesia
Authors: Harisudin M. Noor 
Published: July 2021

This article discusses how Fiqh Nusantara, an Islamic jurisprudence in Indonesia was formed and formulated. Data were obtained through library research, classic literature commonly used in Islamic boarding schools, fatwas of the Indonesian Council of Ulama, Nahdlatul Ulama, and Muhammadiyah. The Fiqh Nusantara contextualization in Indonesian locus – known as Fiqh Nusantara– is posed from distinctive genealogy and characteristics compared to Fiqh that has developed in the Middle East. One of the characteristics of Fiqh Nusantara is that it has strengthened the unity of the Republic of Indonesian as indicated by its various contributions in the national legal system. Additionally, it has been resulted in a dialogical process in which many fatwas developed and lived in the community. It is responsive to recent developments of fiqh and it is not derived from one school of thought. It is created through collective efforts (collective ijtihad) in the form of fiqh which is open to variety of opinions. However, Fiqh Nusantara as an Islamic law in Indonesia has not yet penetrated the domain of mahdlah (sincere worship to the God). For Fiqh Nusantara activists, it was only applicable to the changing domain of fiqh (mutaghayirat) and not to the fixed domain of fiqh (tsawabit).
Assessment of Aflatoxin M1 in human breast milk in Rafsanjan, Iran
Authors: Pourtalebi Somayeh , Ayatollahi Mousavi Seyyed Amin , Assadollahi Zahra , Mousavi Seyyed Mahdi 
Published: July 2021

Background and Purpose: Aflatoxins (AFs) are a group of highly toxic mycotoxins present both in the environment and in foodstuffs. The food of infants should be safe and free of various pollutants, including breast milk mycotoxins. This study aimed to measure the mycotoxin of Aflatoxin M1 (AFM1) in human milk samples obtained from lactating mothers living in Rafsanjan city, Iran.
Materials and Methods: In the current cross-sectional study, breast milk samples were collected from 150 lactating mothers in Rafsanjan city from September 2015 to April 2016 using the structured food-frequency questionnaire. The AFM1 was measured by employing enzyme-linked immunosorbent assay specific kits. The statistical analysis was performed in SPSS software (version 16).
Results: The AFM1 was detected in 98 mothers (65%) with a mean concentration of 14.69±8.15 ng/kg, ranging from 5.02 to 41.25 ng/kg. The AFM1 concentration exceeded the tolerable and accepted limit promulgated by the European Union and the USA (25 ng/kg) in only 10 milk samples. Moreover, in 59 milk samples, the AFM1 concentration exceeded the limit recommended by Australia and Switzerland (10 ng/kg).
Conclusion: According to the results of the present study, lactating mothers and their infants are at risk of AFM1 exposure in southern Iran. Accordingly, the examination of AFM1 concentrations in lactating mothers, as a critical postnatal exposure marker of infants to this carcinogenic compound, requires further studies in various seasonal periods and different parts of Iran.
Effect of Allium cepa on LAC1 gene expression and physiological activities in Cryptococcus neoformans
Authors: Musavinasab-Mobarakeh Seyed Afzal , Shams-Ghahfarokhi Masoomeh , Razzaghi-Abyaneh Mehdi 
Published: July 2021

Background and Purpose: This study aimed to investigate the effects of Allium cepa ethanolic extract (EAC) on Cryptococcus neoformans biological activities and LAC1 gene expression.
Materials and Methods: The minimum inhibitory concentration (MIC) of EAC was determined based on the Clinical and Laboratory Standards Institute M27-A4 method at a concentration range of 125- 4000 µg/ml. The EAC synergism activity was determined in combination with fluconazole (FCZ) as an antifungal azole. Laccase activity, melanin production, and cell membrane ergosterol content of C. neoformans were assessed at the 0.5× MIC concentration of EAC (1000 μg/ml) and FCZ (64μg/ml) by approved methods. The expression of the LAC1 gene was studied in the fungus exposed to 0.5× MIC concentration of EAC and FCZ using the real-time polymerase chain reaction.
Results: Based on obtained results, MIC of EAC and FCZ were 2000 and 128 μg/ml,respectively. A combinatory effect was reported for FCZ and EAC by a fractional inhibitory concentration index of 0.25. The cell membrane ergosterol content was inhibited in EAC- and FCZ-treated C. neoformans by 58.25% and 49.85%, respectively.The laccase activity and melanin production were reduced in EAC-treated C. neoformans by 45.37% and 51.57%, and in FCZ-treated fungus by 54.64% and 53.68%, respectively.The expression of fungal LAC1 at messenger RNA (mRNA) level was measured 0.46 and 0.58 folds and significantly decreased in both EAC- and FCZ-treated C. neoformans at the 0.5×MIC concentration, respectively (p <0.05).
Conclusion: The findings revealed that EAC contains inhibitory compounds which interact with biological activities in C. neoformans and thereby, it could be considered as a potential source for the development of novel antifungal drugs.
First Fluconazole-resistant Candida auris isolated from fungal otitis in Iran
Authors: Taghizadeh Armaki Mojtaba , Mahdavi Omran Saeid , Kiakojuri Keyvan , Khojasteh Shaghayegh , Jafarzadeh Jalal , Tavakoli Mahin , Badali Hamid , Haghani Iman , Shokohi Tahereh , Hedayati Mohammad Taghi , Abastabar Mahdi 
Published: July 2021

Background and Purpose: Candida auris, as a new characterized pathogenic yeast,has attracted remarkable attention in the recent decade due to its rapid global emergence and multidrug resistance traits. This unique species is able to cause nosocomial outbreaks and tolerate adverse conditions; however, it has been mostly misidentified by conventional methods.
Case report: This report aimed to describe the first fluconazole-resistant case of C.auris otitis in an immunocompetent patient in Iran. The isolate showed minimum inhibitory concentration of ≥ 32 μg/ml for fluconazole; however, the patient was treated with topical clotrimazole and miconazole with no recurrence.
Conclusion: This was the second strain of C. auris isolated from otitis in Iran which was fluconazole-resistant, unlike the first Iranian isolate.
First report of chronic invasive fungal rhinosinusitis in a patient with ovarian cancer caused by Didymella pedeiae and successful treatment with voriconazole: A case report
Authors: Raiesi Omid , Hashemi Seyed Jamal , Ibrahim Getso Muhammad , Ardi Pegah , Mohammadi Ardehali Mojtaba , Raissi Vahid , Shamsaei Sina , Borjian Boroujeni Zeinab 
Published: July 2021

Background and Purpose: Didymella pedeiae is a dematiaceous fungus that belongs to the Coelomycetes class. While species within this class are known to cause human infection, D. pedeiae had previously only been known as phytopathogens and had never been isolated from a human sample.
Case report: A 51-year-old Iranian female patient with ovarian cancer was admitted with unilateral lesions in paranasal sinuses and a five-month history of nasal obstruction,headache, postnasal drainage, swelling on the left side of the face, and orbital pain.Paranasal sinus computerized tomography scan revealed a soft tissue mass that filled the left nasal cavity, ethmoid, sphenoid, and frontal sinuses with more involvement in the maxillary and ethmoid sinuses. Antifungal treatment was simultaneously initiated with itraconazole+prednisolone 15 mg/day, and levofloxacin. Due to poor clinical response,IV voriconazole and amphotericin B were added to the treatment as well. The patient recovered completely after 10 weeks of therapy.
Conclusion: Here, we report the first case of human D. pedeiae infection in a patientwith ovarian cancer.
EFFICACY OF REJUVENATION OF LAKES IN BENGALURU, INDIA
Authors: Ramchandra T.V. , Sincy V , Asulabha K.S. 
Published: July 2021

Purpose of the study: The main objective of the present work is to assess the efficacy of the restoration endeavour in Bengaluru lakes, Karnataka, India. Rapid urbanisation coupled with industrialisation in urban areas has greatly stressed the available water resources qualitatively and quantitatively. This has also resulted in the generation of enormous sewage and wastewater after independence.
Method: Environmental monitoring of 40 restored lakes was carried out to identify the key issues and assessing water quality (physical, chemical and biological). Weighted arithmetic water quality index (WQI) and Pearson’s correlation coefficient (r) was determined using data of physicochemical parameters of lakes. Principal Component Analysis (PCA) performed using PAST3 software to identify the factors responsible for variations in water quality.
Main Findings: The monitored forty lakes distributed across the three major watersheds namely Koramangala and Challaghatta valley, Vrishabhavathi valley and Hebbal valley were grouped under three different WQI status like good water quality (10%); poor water quality (37%) and very poor water quality (53%). Majority of these restored lakes has become polluted which indicates improper decontamination and poor maintenance of restored lakes.
Application of this study: This study provides vital information for policymakers to understand the gaps which helps in the course correction while implementing further rejuvenation of lakes.
Novelty/Originality of this study: The efficacy of rejuvenation was assessed through integrated cost-effective scientific approaches for the lake monitoring. Monitoring during the pre and post rejuvenation period has aided in assessing the efficacy of rejuvenation, which is done for the first time in India.
SUSTAINABLE BIOFUEL PRODUCTION FROM ESTUARINE DIATOMS
Authors: Ramchandran T.V. , Gunasekaran Saranya 
Published: July 2021

Purpose of the study: Microalgae with better carbon sequestration potential, higher biomass, and lipid productivity in comparison to terrestrial counterparts is emerging as a viable sustainable alternative to fossil fuels. Diatoms, a subgroup of a broader category of microalgae are well-known for their role as a bio-indicator in palaeo-climatological studies across historical timelines. Understanding ecology, community structure, and habitat preference of diatoms are prerequisites for prioritizing diatom strains towards sustainable biofuel production along with value-added product extraction.
Method: Selection of appropriate strains, economically viable harvesting and environmentally sound transesterification are the challenges faced in microalgal industry. The present study focusses on understanding the variability in benthic diatom community assemblages across seasons and its affinity to different substrata at fixed sampling locations in an estuarine eco-system through field sampling for twelve months covering all seasons.
Main Findings: The results highlight the tolerance and resilience in select diatom strains in fluctuating water qualities and seasonal variations, the insights much needed during mass cultivation under open environments. Statistical data analyses revealed distinct demarcation between sensitive and tolerant species with selective habitat preferences and resilience to fluctuating environmental conditions. Variations of benthic diatom community structure across various substrata highlights substratum affinity of diatom strains. From the inferences derived through field studies, mixed consortia of diatoms were developed, monitored, and optimized for higher biomass and lipid productivity under controlled laboratory conditions.
Application of the Study: The results highlight the prospects of phyco-prospecting of indigenously grown diatom strains for sustainable biofuel production.
THE COMPARISON OF GC-MS DATA OF LEAVES OF ALOE VERA (A. BARBADENSIS MILL) PLANT GROWN IN DIFFERENT SOIL COMBINATIONS WITH CHEMICAL LAB WASTES
Authors: Rai Preeti , Chatrath Harsha 
Published: July 2021

Purpose of the study: The main purpose of this study is to do the comparison of the chemical constituents present in the leaves of Aloe Vera (A. barbadensis Mill) plant grown in different soil combinations using Gas Chromatography- Mass Spectrometry (GC-MS) data analysis. Plants were grown in two different combinations of soil, one in normal soil and the other in the combination of normal soil and solid chemical waste obtained from the chemistry laboratory of an educational institute. Methodology: One Aloe Vera (A. barbadensis Mill) plant was grown in normal soil without adding any compost or any fertilizer to the soil. The other plant was grown in soil, which was combined with the solid chemical waste collected from the chemistry laboratory. After observing the morphological characters of the plants, plants were studied for the chemical constituents present in them by using GC-MS data analysis technique. Main Findings: Growth of plants depends on the soil composition, physical characters and the surrounding environment. How the variation in chemical composition of soil affects the chemical constituents of plant leaves, has been discussed in this paper. According to morphological characters the Aloe Vera (A. barbadensis Mill) plant grown with soil combined with solid chemical waste has shown better results compared with the one grown in normal soil. GC-MS results also indicated variation in the chemical constitution of plant leaves taken for the research experiment. Applications of this study: This study has helped to understand that the soil environment and soil nutrients are largely responsible for the changes in chemical constituents of plants. This study can be applied to the other plants as well. Novelty/Originality of this study: In place of fertilizers, solid chemical waste from the laboratory was used for the research purpose. The method is useful and if implemented on a large scale, will help to curb pollution caused by educational institutes to some extent. This kind of research is not done previously by any other researcher.
A COMPARATIVE STUDY OF PHYSICOCHEMICAL PARAMETERS OF BIRD'S VALLEY, PUNE QUARRY WATER AND DRINKING WATER
Authors: Kokcha Shashikala , Chatrath Harsha 
Published: July 2021

Purpose of the study: The purpose behind this study is to get the knowledge of the range of physicochemical parameters of the Bird's valley, Pune quarry water in comparison with the drinking water.
Methodology: With the help of clean and sterilized polyethylene bottles of 1 liter capacity have been used for the collection of quarry water. Total 21 physico-chemical parameters have been analyzed and compared with the values for the drinking water. Analysis of water is carried out in the laboratory with the help of standard methods and techniques.
Main Findings: Presence of mercury in quarry water is very much high i-e 0.006 mg/liter and coli form bacteria are also numerous in count.
Applications of this study: This study gives us the idea about the range of the parameters of quarry water in comparison with drinking water and after the suitable treatment it could be converted into drinking water or not.
Novelty/Originality of this study: Till the date no work has been done on quarry water like this, present study will help us to understand whether the quarry water could be used as a potable water or not.
DESTINATION IMAGE ANALYSIS AND ITS STRATEGIC IMPLICATIONS: A LITERATURE REVIEW FROM 1990 TO 2019
Authors: Huang Ren-Yi , Chang Wen-Jung , Chang Chiung-Yun 
Published: July 2021

Purpose of the study: "Image" not only exists in the market of consumer goods as well as tourism but also is the criteria usually used by consumers to make decisions. However, little literature is concerned with a comprehensive analysis of its development trajectory, application domains, and strategic implications. This study aims at conducting an extensive review of DI's current literature to examine the key concept of consumer behaviors.
Methodology: Based on Scopus, this paper surveys the development trajectory of destination image using a literature review with the solo keyword “destination image” from 1990 to 2019.
Main findings: The findings indicate that the development of destination image begins in 1995 and the overall growth is steady and strong. There are three development waves, such as 2002-2007, 2008-2013, and 2015-2019. These 908 articles were scattered across 182 different journals. Besides, all these keywords related to counties/areas are mostly equipped with tourism competitiveness as well.
Applications of this study: This study reveals five problem domains of destination image including environment and government, destinations, tourists, culture, and others, respectively. This would call the attention of the executives and authorities concerned with environmental sustainability, adaptability/responsiveness of strategies, destination competitiveness, capabilities development, resource allocation, and tourist behavior (e.g., decision-making and post-purchase intention).
Originality/Value: Based on the nexus between “environment-destination-tourist”, this study proposed a strategic map of DI to future researchers and field workers of great interests to operationalize and conceptualize its coverage.
LIFECOMP: El Marco de Referencia Europeo para la competencia personal, social y de a aprender a aprender. Relevancia en el contexto de la Covid-19
Authors: Cabrera Giráldez Marcelino 
Published: July 2021

Respetando el principio de la subsidiariedad, la Unión Europea promueve las competencias clave para el aprendizaje permanente. Una de las ocho que enunció el Consejo Europeo en su Recomendación de 2018 sobre competencias clave es la competencia ‘Personal, Social y de Aprender a aprender’. LifeComp es el marco conceptual europeo para esta competencia, que establece las tres áreas y las nueve subcompetencias que la componen: Autorregulación, Flexibilidad y Bienestar (Área personal); Empatía, Comunicación y Colaboración (Área social); Mentalidad de crecimiento, Pensamiento crítico y Gestión del aprendizaje (Aprender a aprender). El marco conceptual fue publicado en junio de 2020. Tener las competencias enunciadas por LifeComp se ha mostrado de particular relevancia en el contexto de la pandemia de la Covid-19. Describimos el marco y damos algunas indicaciones sobre su potencial para los ciudadanos tanto ahora como en la postpandemia.
Recibido: 29.05.2021Aceptado: 18.06.2021