bluuebunny/crossref_metadata_2025_split huggingface dataset:
Habiller l’espace rituel de la salle d’audience. Catégorisations scéniques dans les audiences pénales de première instance en Belgique
Authors: D’hondt Sigurd 
Published: December 2021

Cet article introduit la notion de catégorisation scénique pour référer aux tentatives des acteurs du procès d’influencer la négociation des réalités juridiques en invoquant des identités catégorielles attirant l’attention sur le cadre dans lequel ces négociations ont lieu. En s’appuyant sur un travail de terrain ethnographique dans des tribunaux pénaux de première instance belges, deux types récurrents de telles catégorisations scéniques sont identifiés. Le premier se produit lorsque les avocats de la défense dépeignent leur client comme « un autre », invitant ainsi les acteurs professionnels co-présents dans la salle d’audience à participer à une inspection visuelle de l’apparence et du comportement de leur client. Le second se produit lorsque les participants profanes, souvent des accusés issus d’une minorité ethnique non représentés par un avocat, refusent de traiter le juge comme enquêteur neutre et à la place effectuent les identités antagonistes « membre de la minorité » contre « représentant de la société en général ». Dans la discussion, il est soutenu que ces catégorisations scéniques ajoutent une dimension additionnelle à la transformabilité des catégories inhérent au processus juridique de catégorisation et qu’ils compliquent ainsi l’image habituelle de la salle d’audience comme espace ritualisé.
Health-related quality of life of patients after breast cancer treatment
Authors: Kaur Maninder Deep , Yadav Budhi Singh , Dahiya Divya , Kaur Sukhpal , Sharma Akhilesh , Ghoshal Sushmita 
Published: December 2021

BACKGROUND:
Survival for breast cancer (BC) patients has improved significantly because of better treatment availability. However, patients may experience side effects after the completion of the treatment, which consequently affect their quality of life (QoL). The present study was planned to assess the QoL of BC patients after the completion of treatment.

SUBJECTS AND METHODS:
One hundred patients of BC after the completion of treatment from the Department of Radiation Oncology, PostGraduate Institute of Medical Education and Research, Chandigarh, India, were enrolled in the study during December 2017 to December 2018. EORTC QLQ C30/+BR23 questionnaires were used to quantify the QoL of these patients.

RESULTS:
The mean age of the participants was 49.35 ± 8.66 years. Mean global health status (GHS) QoL score was 64.6 ± 13.6. Functional scales, in most of the domains were high, whereas symptom scales were moderate to low for most items, showing better QoL. Pain (40.6 ± 19.1) and fatigue (54.8 ± 16.1) were the most disturbing symptoms. Patients exhibited higher scores for sexual functioning, whereas the least score was for future perspective.

CONCLUSIONS:
There was significant overall improvement in the QoL of patients with BC after the completion of treatment regarding functional scales and symptom scales as per EORTC QLQ-C30 questionnaire. As per EORTC QLQ-BR23 questionnaire, there was deterioration of the QoL concerning future perspectives for functional scale and hair loss for symptom scales.
Elevated mRNA expression levels of inflammation-related genes in triple-negative breast cancer
Authors: Sultana Rizwana , Salman Chisty Syed Javed 
Published: December 2021

BACKGROUND:
The prevalence of Triple-Negative breast cancer (TNBC) accounts for a large percentage of breast cancer cases in India. TNBC is associated with poor prognosis, higher mortality rate, ill-defined molecular etiology, and hence limited therapeutic interventions.

AIM:
The aim of this study is to evaluate the association of certain inflammatory markers with TNBC pathogenesis.

MATERIALS AND METHODS:
Prospectively collected resected breast cancer tissue samples along with adjacent normal control (n = 100) were prospectively collected in RNA Later. Differential mRNA expression analysis of inflammatory-related genes namely; inducible nitric oxide synthase (iNOS), endothelial nitric oxide synthase (eNOS), cyclooxygenase-2 (COX2), and Nuclear Factor Kappa B (NFκB) and were evaluated in non-TNBC and TNBC tissues samples along with adjacent normal control tissue samples with the help of mRNA specific primers using reverse transcription-polymerase chain reaction. Statistical analysis was performed using SPSSv13.0 software.

RESULTS:
A total of 60 non-TNBC and 40 TNBC tissue samples along with adjacent normal control were included for the study with informed consent and clinical details. The mean age of the TNBC patients was 39 ± 9 years, All the breast cancer cases were clinically staged as Infiltrating Duct Carcinoma (non-TNBC-invasive ductal carcinoma [IDC] II [n = 29 cases], non-TNBC-IDC III [n = 31 cases], TNBC-IDCII [n = 22 cases], TNBC-IDC III [n = 18 cases]). The results showed an upregulation of all the markers in TNBC cases compared to non-TNBC vis-avis non-neoplastic adjacent control area. Second, significant changes in iNOS mRNA expression were found to be associated with severity of TNBC cases (P = 0.020), while the expression of constitutively expressed eNOS was comparative between IDC-II and IDC-III stages of TNBC.

CONCLUSIONS:
The present study indicates that the mRNA-based differential expression results showed an upregulation of all the markers (iNOS, eNOS, COX2, and NFκB) in TNBC cases compared to non-TNBC cases vis-a-vis non-neoplastic adjacent control area. Significant changes in iNOS mRNA expression were found to be associated with severity of TNBC cases (P = 0.020), depicting the role of iNOS-induced inflammation in the pathogenesis of TNBC.
Effect of the Resin-Based Adhesive Coating on the Shear Punch Strength of Aesthetic Restorative Materials
Authors: Mohammadi Najmeh , Bagheri Rafat , Borazjani Lida Vaziri 
Published: December 2021

Introduction:
This study aimed to investigate the effect of G-Coat Plus (GCP) on the shear punch strength (SPS) of conventional glass ionomer cements (CGICs) and resin composites (RCs).

Materials and methods:
In this experimental study, four groups of restorative materials (two CGICs (Equia Forte Fil and Fuji Bulk), and two RCs (Aura Bulk fil and Filtek Z250) were used. Twenty specimens were prepared for each material. GCP was applied on the first subgroup (n = 10). The specimens were stored in distilled water at 37°C, and SPS values were measured after 24 hours. Two-way analysis of variance and independent t test were used for data analysis.

Results:
RCs showed significant higher SPS values compared to the CGICs (P < 0.001). All materials tested showed increased SPS values after applying GCP (P < 0.05).

Conclusion:
Applying GCP significantly improves the SPS of tooth-colored restorative materials used in this study.
Comparative Evaluation of Calendula officinalis and 2% Chlorhexidine against Enterococcus faecalis and Candida albicans
Authors: Vinola Selvanathan M. J. , Sekar Mahalaxmi , Renganathan Senthil Kumar , Dhiraviam Selvanathan 
Published: December 2021

Background:
Endodontic infections require effective removal of microorganisms from the root canal system for long-term prognosis. Chlorhexidine (CHX) is one of the most effective irrigants, but it's few drawbacks warrant search for newer alternatives.

Aim:
The aim of this study is to evaluate the antimicrobial efficacy of Calendula officinalis (CO) and 2% CHX against Enterococcus faecalis (E. faecalis) and Candida albicans (C. albicans).

Materials and Methods:
The antimicrobial activity of CO extract and 2% CHX against E. faecalis and C. albicans was checked by the agar diffusion method and the zone of inhibition was statistically analyzed.

Results:
CHX has significantly more antimicrobial activity than CO against E. faecalis and C. albicans. However, CO also possesses reasonable antimicrobial activity against E. faecalis and antifungal activity against C. albicans.

Conclusion:
Under the limitations of this study, it can be concluded that CO has antimicrobial and antifungal activity against E. faecalis and C. albicans; however, CHX is more potent.
Association of Human Papillomavirus with other Coinfections Prevailing in Abnormal Cervical Lesions
Authors: Mohanty Gangotree , Singha Partha , Datta Chhanda , Dutta Sankhadeep , Panda Chinmay Kumar 
Published: December 2021

Purpose:
Human papillomavirus (HPV) is a common and necessary cause for cervical cancer development. However, association of other microbial infections such as bacterial vaginosis (BV), trichomonas vaginalis (TV), and hepatitis B virus (HBV) with HPV in development of the disease is not clear. This study aimed to evaluate the association of HPV with the other coinfections with the development of cervical lesions.

Materials and Methods:
Cervical smears of 120 women (age range 20–70 years) were screened by cytology/serology for detection of BV, TV, and HBV. The prevalence of HPV and its copy number were detected by polymerase chain reaction-based methods.

Results:
HPV infection was infrequent (4%) in normal cytology samples followed by increase in atypical squamous cell of undetermined significance (ASCUS) (60.4%), low-grade squamous intraepithelial lesion (LSIL) (94.1%), high-grade squamous intraepithelial lesion (HSIL) (100.0%), and squamous cell carcinoma (SCC) (100.0%). HPV 16 infection was prevalent than HPV 18 along their coinfections in some samples. The other microbial infections were comparatively less frequent (28.0%) in normal cytology samples than ASCUS (83.3%), LSIL (44.1%), HSIL (58.3%), and SCC (100.0%). BV infection was found in normal cytology as well as in ASCUS, LSIL, and HSIL samples, whereas TV infection was absent in normal cytology though prevalent in other cervical lesions. HBV infection was seen in only one ASCUS sample.

Conclusions:
Significant high HPV 16 copy number was seen to be associated with other microbial infections than the infection negative samples. Coinfection of HPV with other microbes has association with severity of cervical lesions.
Megestrol Acetate in Cancer Cachexia and Anorexia
Authors: Fatima Kaneez , Andleeb Asifa , Hussain Imtiyaz , Sofi Mushtaq Ahmed , Fir Afroz , Qadri Sumyra Khurshid 
Published: December 2021

Background:
In clinical practice, the management of cancer-related anorexia/cachexia syndrome (CACS) is a great challenge. We conducted an observational study to find the effectiveness and safety of megestrol acetate (MA) for the treatment of CACS.

Patients and Methods:
One hundred patients of advanced cancer were randomly assigned in the study. Patients received MA 160 mg/oral twice daily. The duration of treatment was 8 weeks.

Results:
The analysis of the study group demonstrated a statistically significant increase from baseline in body weight (P ≤ 0.01), quality of life (P = 0.02), appetite (P = 0.01), and the Eastern Cooperative Oncology Group performance status (P = 0.03).

Conclusion:
We concluded that MA is effective and safe in the treatment of CACS.
Study of Effect of Corona-19 Pandemic on Radiation Oncology Practice – Single Institution Experience
Authors: Rao Arpitha S , Mohan Florence P 
Published: December 2021

Context:
The COVID-19 pandemic has posed a big challenge to provision of health care. Cancer patients are considered to be at higher risk of developing complications from COVID-19 as they are often immunosuppressed. At the same time, treatment delays and late diagnosis during the pandemic due to travel restrictions, staff shortage, active COVID infections to patients or family members, etc., can lead to tumor progression and poor oncological outcomes.

Aims:
This retrospective observational study was undertaken to know the effect of the corona pandemic and consequent lockdown on the radiation treatment of oncology patients in our department.

Materials and Methods:
Subjects of the study were the patients who attended the Oncology Department of Kamineni Academy of Medical Sciences, Hyderabad, which is a tertiary care center, during the COVID-19 pandemic. The study period was 6 months starting from the lockdown on April 24, 2020.

Results:
In our study, treatment of 16 out of 150 patients (10.67%) was affected due to the lockdown situation consequent to COVID-19 pandemic. Eight patients had treatment interruptions for more than 5 days, six patients discontinued their treatment, and two patients delayed their treatment due to lockdown. Eight patients tested positive for COVID-19 before starting treatment. Out of them, four did not come back for treatment. The mean delay in radiation treatment in the other four patients was 35 days. Two patients had CORAD scores consistent with COVID-19 but were reverse transcription–polymerase chain reaction negative. Two patients turned positive during treatment after which they did not come back. Totally 9.3% (14/150) of the patients' treatment was affected due to corona infection.

Conclusions:
In our study, almost 20% of the patients' treatment was affected directly or indirectly by the COVID-19 pandemic situation. This in turn may lead to rise in cancer mortality in future.
Evaluation of the efficacy of Zataria multiflora essential oil versus albendazole in patients infected with liver cystic echinococcosis
Authors: Jafari Arash , Moazeni Mohammad , Hosseini Seyed Vahid , Khazraei Hajar , Pourahmad Saeedeh 
Published: December 2021

Background:
Cystic echinococcosis (CE) is a life-threatening disease in many countries. Albendazole, as the drug of choice for medical treatment of CE, is accompanied by adverse effects and may be ineffective in 20%–40% of cases; hence, new and more effective compounds are urgently needed to optimize the management of the disease. This study was performed to evaluate the efficacy of Zataria multiflora essential oil (ZMEO) versus albendazole against human liver CE.

Materials and Methods:
In this nonrandomized and single-blinded clinical trial, thirty patients who were infected with liver CE were divided into two groups (15 in each) and treated with albendazole (800 mg daily) and ZMEO (60 mg daily), respectively. Albendazole and ZMEO were administered orally for 180 consecutive days. The volume of hydatid cysts was measured by ultrasonography before and 2, 4 and 6 months after the start of treatment. Simultaneously, biochemical analysis was performed on the blood samples of patients to assess the possible side effects of the two treatment regimens.

Results:
Two, 4 and 6 months after the start of treatment, ZMEO indicated a significantly higher ability in reduction of the volume of the hydatid cysts, compared to albendazole (P < 0.05). The mean values of aspartate aminotransferase, alanine transaminase and alkaline phosphatase were also significantly lower in the patients treated with ZMEO in comparison to those treated with albendazole (P < 0.05). No clinical adverse effects were observed in the patients treated by ZMEO.

Conclusion:
From the point of view of efficacy and safety, ZMEO indicated a significant superiority to albendazole. Hence, ZMEO may be considered as an alternative for albendazole in the medical treatment of liver CE.
The all-or-nothing phenomenon in sparse linear regression
Authors: Reeves Galen , Xu Jiaming , Zadik Ilias 
Published: December 2021

We study the problem of recovering a hidden binary

k

-sparse

p

-dimensional vector

\beta

from

n

noisy linear observations

Y=X\beta+W

, where

X_{ij}

are i.i.d.

\mathcal{N}(0,1)

and

W_i

are i.i.d.

\mathcal{N}(0,\sigma^2)

. A closely related hypothesis testing problem is to distinguish the pair

(X,Y)

generated from this structured model from a corresponding null model where

(X,Y)

consist of purely independent Gaussian entries. In the low sparsity

k=o(\sqrt{p})

and high signal-to-noise ratio

k/\sigma^2 \to \infty

regime, we establish an “all-or-nothing” information-theoretic phase transition at a critical sample size

n^{\ast}=2 k\log (p/k) /\log (1+k/\sigma^2)

, resolving a conjecture of Gamarnik and Zadik (2017). Specifically, we show that if

\liminf_{p\to \infty} n/n^{\ast}>1

, then the maximum likelihood estimator almost perfectly recovers the hidden vector with high probability and moreover the true hypothesis can be detected with a vanishing error probability. Conversely, if

\limsup_{p\to \infty} n/n^{\ast}<1

, then it becomes information-theoretically impossible even to recover an arbitrarily small but fixed fraction of the hidden vector support, or to test hypotheses strictly better than random guess.

Our proof of the impossibility result builds upon two key techniques, which could be of independent interest. First, we use a conditional second moment method to upper bound the Kullback–Leibler (KL) divergence between the structured and the null model. Second, inspired by the celebrated area theorem, we establish a lower bound to the minimum mean squared estimation error of the hidden vector in terms of the KL divergence between the two models.
An extended abstract version of this work appeared at the Proceedings of the Conference on Learning Theory (COLT), 2019.
Differentiating children with familial Mediterranean fever from other recurrent fever syndromes: The utility of new Eurofever/PRINTO classification criteria
Authors: Miray Kışla Ekinci Rabia , Balcı Sibel , Hakan Erol Ahmet , Karagöz Dilek , Ufuk Altıntaş Derya , Bisgin Atıl 
Published: December 2021

Objectives: In this study, we aimed to investigate the performance of Eurofever Registry and the Paediatric Rheumatology International Trials Organisation (PRINTO) classification criteria in pediatric patients with familial Mediterranean fever (FMF).
Patients and methods:This retrospective, cross-sectional study included a total of 130 pediatric FMF patients (67 males, 63 females; mean age: 12.4±3.6 years; range, 2.5 to 17.7 years) with at least one M694V mutation in MEFV gene between July 2010 and July 2019. Demographic features and disease characteristics were recorded. The control group was consisted of 41 patients (19 males, 22 females; mean age: 7.8±4.0 years; range, 2.1 to 17.8 years) with other hereditary autoinflammatory diseases (AIDs), including periodic fevers with aphthous stomatitis, pharyngitis, and adenitis syndrome (n=30), mevalonate kinase deficiency (n=9), and tumor necrosis factor receptor-associated periodic syndrome (n=2). Sensitivity and specificity of the Eurofever/PRINTO classification criteria were calculated.
Results: The sensitivity and specificity were 97.7% and 56.1% for Yalcinkaya-Ozen criteria, respectively and 93.1% and 90.2% for Tel Hashomer criteria, respectively. The Eurofever/PRINTO classification criteria reached a sensitivity and specificity of 94.6% and 82.9% and 93.1% and 80.5%, respectively, when genetic plus clinical criteria and clinical-only criteria were applied.
Conclusion: The Eurofever/PRINTO classification criteria have a comparable sensitivity for avoidance of FMF underdiagnosis in childhood. The Yalcinkaya-Ozen criteria have the highest sensitivity without a significant specificity. The Tel Hashomer criteria and Eurofever/PRINTO classification criteria were superior to Yalcinkaya-Ozen criteria to differentiate FMF from other AIDs, thus leading to less complications relevant to underdiagnosis of other AIDs.
Lupus-related vasculitis in a cohort of systemic lupus erythematosus patients
Authors: Gamal Sherif M , Mohamed Sally S. , Tantawy Marwa , Siam Ibrahem , Soliman Ahmed , Niazy Marwa H. 
Published: December 2021

Objectives: This study aims to examine the frequency and clinical association of lupus-related vasculitis in patients with systemic lupus erythematosus (SLE).
Patients and methods: We retrospectively analyzed medical records of a total of 565 SLE patients (42 males, 523 females; mean age: 32.7±9.5 years; range, 13 to 63 years) between January 2017 and February 2020. Demographic, clinical data, and laboratory data and treatment modalities applied were recorded. Lupus-related vasculitis and its different types were documented, and the patients with vasculitis were compared with those without vasculitis.
Results: The mean disease duration was 8.9±6.3 years. Vasculitis associated with lupus was found in 191 (33.45%) patients. Cutaneous vasculitis was found in 59.2%, visceral vasculitis in 34.0%, and both in 6.8% of total vasculitis patients. The patients with vasculitis had a longer disease duration (p=0.01), were more likely to have juvenile onset (p=0.002), livedo reticularis (p<0.001), Raynaud's phenomenon (RP) (p<0.001), digital gangrene (p<0.001), thrombosis (p=0.003), and cranial neuropathy (p=0.004). The patients with vasculitis showed a higher prevalence of hypercholesterolemia (p=0.045), diabetes mellitus (p=0.026), higher Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) at disease onset (p<0.001), and Systemic Lupus International Collaborating Clinics (SLICC) Damage Index (p=0.003) scores. They had more prevalent hematological manifestations (p<0.001), hypocomplementemia (p=0.007), received a higher cumulative dose of intravenous methylprednisolone (p<0.001), and had also more frequent cyclophosphamide (p=0.016) and azathioprine intake (p<0.001). In the logistic regression analysis, SLE vasculitis was independently associated with juvenile disease onset, livedo reticularis, RP, hematological manifestations, and higher scores of SLEDAI at disease onset (p<0.05).
Conclusion: Juvenile disease onset, livedo reticularis, RP, hematological manifestations, and higher SLEDAI scores at disease onset may be associated with the development of vasculitis in SLE patients.
The plasma microRNA levels and their relationship with the general health and functional status in female patients with fibromyalgia syndrome
Authors: Akaslan Erbil , Güvener Orhan , Görür Ayşegül , Havva Çelikcan Didem , Tamer Lülüfer , Biçer Ali 
Published: December 2021

Objectives: The aim of this study was to identify the plasma level of micro-ribonucleic acid (microRNA) expressions and the relationship between plasma microRNA levels with the general health and functional status in female patients with fibromyalgia syndrome (FMS).
Patients and methods: Thirty-five female patients (mean age: 42.0±11.8 years; range, 21 to 62 years) diagnosed as FMS and 35 sex-and age-matched healthy controls (mean age: 43.7±8.8 years; range, 21 to 56 years) were enrolled in the study. MicroRNA measurements of the participants in plasma were carried out by using the quantitative polymerase chain reaction (qPCR). A total of 11 plasma levels of microRNA expressions were examined in both groups. The general health and functional status of the patients and controls were assessed by the Fibromyalgia Impact Questionnaire (FIQ) and the Short Form-36 (SF-36) scale.
Results: No significant difference was observed between the plasma levels of microRNA expressions in patients with FMS and healthy controls. The plasma level of miR-320a expression was found to be negatively correlated with the total FIQ score in female patients with FMS (p=0.05, r=-0.34). Negative correlations were also detected between the plasma level of miR-320a and miR-320b expressions and the subscale score of SF-36 physical function in female patients with FMS (p=0.01, r=-0.43 and p=0.01, r=-0.43, respectively). A strong positive correlation was found between miR-142-3p and the subscale score of SF-36 mental symptom score in female patients with FMS (p<0.001, r=1.00).
Conclusion: The expression levels of microRNAs in plasma between female patients with FMS and controls were not significantly different. Only plasma levels of miR-320a, miR-320b, and miR-142-3p expressions were associated with the general health, functional status, and mental symptom score in female patients with FMS.