bluuebunny/crossref_metadata_2025_split huggingface dataset:
Water soluble flexible and wearable electronic devices: a review
Authors: Bokka Naveen , Selamneni Venkatarao , Adepu Vivek , Jajjara Sandeep , Sahatiya Parikshit 
Published: November 2021

Abstract
Electronic devices that are biodegradable, water soluble and flexible and are fabricated using biodegradable materials are of great importance due to their potential application in biomedical implants, personal healthcare etc. Moreover, despite the swift growth of semiconductor technologies and considering a device’s shell life of two years, the subject of electronic waste (E-waste) disposal has become a major issue. Transient electronics is a rapidly expanding field that solves the issue of E-waste by destroying the device after usage. The device disintegration can be caused by a multitude of triggering events, an example is that the device totally dissolves and/or disintegrates when submerged in water. This technology enables us to utilize electronic devices for a set amount of time before quickly destroying them, lowering E-waste significantly. This review will highlight the recent advancement in water-soluble flexible electronic devices with more focus on functional materials (water insoluble), fabrication strategies and transiency understanding with special importance on areas where these devices exhibit potential application in flexible and wearable electronic devices which includes field effect transistors, photodetectors, memristors and sensors for personal healthcare monitoring.
A random-sampling method as an efficient alternative to variational Monte Carlo for solving Gutzwiller wavefunctions
Authors: Zhang Feng , Ye Zhuo , Yao Yong-Xin , Wang Cai-Zhuang , Ho Kai-Ming 
Published: November 2021

Abstract
We present a random-sampling (RS) method for evaluating expectation values of physical quantities using the variational approach. We demonstrate that the RS method is computationally more efficient than the variational Monte Carlo method using the Gutzwiller wavefunctions applied on single-band Hubbard models as an example. Non-local constraints can also been easily implemented in the current scheme that capture the essential physics in the limit of strong on-site repulsion. In addition, we extend the RS method to study the antiferromagnetic states with multiple variational parameters for 1D and 2D Hubbard models.
Learning protein subcellular localization multi-view patterns from heterogeneous data of imaging, sequence and networks
Authors: Wang Ge , Xue Min-Qi , Shen Hong-Bin , Xu Ying-Ying 
Published: November 2021

AbstractLocation proteomics seeks to provide automated high-resolution descriptions of protein location patterns within cells. Many efforts have been undertaken in location proteomics over the past decades, thereby producing plenty of automated predictors for protein subcellular localization. However, most of these predictors are trained solely from high-throughput microscopic images or protein amino acid sequences alone. Unifying heterogeneous protein data sources has yet to be exploited. In this paper, we present a pipeline called sequence, image, network-based protein subcellular locator (SIN-Locator) that constructs a multi-view description of proteins by integrating multiple data types including images of protein expression in cells or tissues, amino acid sequences and protein–protein interaction networks, to classify the patterns of protein subcellular locations. Proteins were encoded by both handcrafted features and deep learning features, and multiple combining methods were implemented. Our experimental results indicated that optimal integrations can considerately enhance the classification accuracy, and the utility of SIN-Locator has been demonstrated through applying to new released proteins in the human protein atlas. Furthermore, we also investigate the contribution of different data sources and influence of partial absence of data. This work is anticipated to provide clues for reconciliation and combination of multi-source data for protein location analysis.
Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signalling
Authors: Zhu Qiuyu Martin , MacDonald Bryan T , Mizoguchi Taiji , Chaffin Mark , Leed Alison , Arduini Alessandro , Malolepsza Edyta , Lage Kasper , Kaushik Virendar K , Kathiresan Sekar , Ellinor Patrick T 
Published: November 2021

AbstractAimsGenetic studies have implicated the ARHGEF26 locus in the risk of coronary artery disease (CAD). However, the causal pathways by which DNA variants at the ARHGEF26 locus confer risk for CAD are incompletely understood. We sought to elucidate the mechanism responsible for the enhanced risk of CAD associated with the ARHGEF26 locus.Methods and resultsIn a conditional analysis of the ARHGEF26 locus, we show that the sentinel CAD-risk signal is significantly associated with various non-lipid vascular phenotypes. In human endothelial cell (EC), ARHGEF26 promotes the angiogenic capacity, and interacts with known angiogenic factors and pathways. Quantitative mass spectrometry showed that one CAD-risk coding variant, rs12493885 (p.Val29Leu), resulted in a gain-of-function ARHGEF26 that enhances proangiogenic signalling and displays enhanced interactions with several proteins partially related to the angiogenic pathway. ARHGEF26 is required for endothelial angiogenesis by promoting macropinocytosis of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) on cell membrane and is crucial to Vascular Endothelial Growth Factor (VEGF)-dependent murine vessel sprouting ex vivo. In vivo, global or tissue-specific deletion of ARHGEF26 in EC, but not in vascular smooth muscle cells, significantly reduced atherosclerosis in mice, with enhanced plaque stability.ConclusionsOur results demonstrate that ARHGEF26 is involved in angiogenesis signaling, and that DNA variants within ARHGEF26 that are associated with CAD risk could affect angiogenic processes by potentiating VEGF-dependent angiogenesis.
Parental mental health, socioeconomic position and the risk of asthma in children—a nationwide Danish register study
Authors: Heuckendorff Signe , Johansen Martin Nygård , Overgaard Charlotte , Johnsen Søren Paaske , Kelly Yvonne , Fonager Kirsten 
Published: November 2021

AbstractBackgroundParental mental illness affects child health. However, less is known about the impact of different severities of maternal depression and anxiety as well as other mental health conditions. The objective of this study was to examine the impact of different severities of maternal and paternal mental health conditions on child asthma.MethodsThis nationwide, register-based cohort study included all children in Denmark born from 2000 to 2014. Exposure was parental mental health conditions categorized in three severities: minor (treated at primary care settings), moderate (all ICD-10 F-diagnoses given at psychiatric hospital) and severe (diagnoses of severe mental illness). The children were followed from their third to sixth birthday. Child asthma was identified by prescribed medication and hospital-based diagnoses. Incidence rate ratios were calculated using negative binomial regression analyses.ResultsThe analyses included 925 288 children; 26% of the mothers and 16% of the fathers were classified with a mental health condition. Exposed children were more likely to have asthma (10.6–12.0%) compared with unexposed children (8.5–9.0%). The three severities of mental health conditions of the mother and the father increased the risk of child asthma, most evident for maternal exposure. Additive interaction between maternal mental health conditions and disadvantaged socioeconomic position was found.ConclusionWe found an increased risk of asthma in exposed children, highest for maternal exposure. Not only moderate and severe, but also minor mental health conditions increased the risk of child asthma. The combination of mental health condition and disadvantaged socioeconomic position for mothers revealed a relative excess risk.
Application of the mixing length theory to assess the generation of melt in internally heated systems
Authors: Vilella K , Kamata S 
Published: November 2021

Summary
Melting in planetary mantles plays a key role in their thermo-chemical evolution. Assessing the amount and location of melting generally requires the 3D temperature fields of the system, such that 3D numerical simulations are in principle necessary prohibiting us from exploring wide ranges of conditions. To overcome this issue, we propose a new 1D analytical framework estimating at first order the amount and depths of melting for a simplified convective system. To do so, we develop an approach, partly based on an extended version of the mixing length theory, able to estimate the distribution of the hottest temperatures in natural systems. The approach involves several free parameters that are calibrated by fitting 3D numerical simulations. We demonstrate that our algorithm produces melting profiles at steady-state and long-term evolutions in fairly good agreement with 3D numerical simulations. We then apply our framework to a wide variety of planetary sizes and heating rates. We find that an increase in planetary radius R increases the depth of melting for small planets (R &lt; 800 km) but decreases it for larger planets. This is caused by the pressure dependence of the solidus.
Home as an Aid: Domestic Design for Disabled Polio Survivors
Authors: Myjak-Pycia Anna 
Published: November 2021

Abstract
This article examines domestic interior design developed and propagated by the home economics movement in post-war America for women physically disabled by the poliovirus and other causes resulting in similar impairments. It argues that domestic interior design was maximally assistive, facilitating the disabled in their everyday tasks, in particular domestic labour. This article shows that home economists fostered post-war efforts supporting the disabled in the following ways: 1) in addition to designing individual domestic aids, they developed more effective holistic spatial solutions, 2) in addition to devising and teaching bodily techniques to help the disabled in their daily tasks, they advanced the social notion of disability by addressing the disability circumstantially: creating accommodating environments that alleviated the effects of physical constraints, often by harnessing societal means (institutional, financial, and legislative), 3) they defied the stereotype portraying women with physical constraints as unproductive and unsuited for marriage, childcare, and housekeeping by presenting the disabled homemaker as being capable, especially when equipped with adequate aids, and deserving to have a family of their own. Furthermore, this article explains how and why the home economists did not undermine traditional gender roles.
Structural Features and Phylogenetic Implications of Three New Mitochondrial Genomes of Blister Beetles (Coleoptera: Meloidae)
Authors: Zhou Zhicheng , Liu Yangyang , Chen Xiangsheng 
Published: November 2021

Abstract
The mitochondrial genome sequences of Denierella emmerichi, Epicauta curvispina, and Meloe poggii were determined. Their mitochondrial genomes were found to contain 37 genes (13 protein-coding genes [PCGs], 22 tRNA genes, and 2 rRNAs), of which 4 PCGs, 8 tRNA genes, and 2 rRNAs are encoded by the N-strand, and the remaining genes are encoded by the J-strand. The mitochondrial genomes of D. emmerichi, E. curvispina, and M. poggii are 15,702 bp, 15,813 bp, and 15,626 bp in length, respectively, and their guanine–cytosine contents are 28%, 33%, and 36%, respectively. The 13 PCGs of D. emmerichi, E. curvispina, and M. poggii use ATN as the standard start codon and TAA, TAG, and T as the stop codons. The Bayesian inference and maximum likelihood phylogenetic analysis results based on the 13 PCGs and 13 PCGs + 2rRNAs datasets of the mitochondrial genomes of the Meloidae support Epicauta (Coleoptera: Meloidae) ([D. emmerichi, E. curvispina, E. ruficeps, E. aptera] + [E. chinensis, E. impressicornis, E. gorhami, E. tibialis]). We believe that this research enriches the literature on the mitochondrial genomics of Meloidae and serves as a foundation for the further study of the phylogenetic relationships and characterization of Meloidae and Coleoptera.
Tissue dissection with saline injection: application in thyroid surgery
Authors: Stefanou Stefanos K , Koulas Spyros , Stefanou Christos K , Tepelenis Kostas , Paxinos Apostolos K , Tsiantis Thomas , Galani Vasiliki , Vlachos Konstantinos 
Published: November 2021

Abstract
Postoperative hypoparathyroidism is a thyroidectomy complication. The effect of this complication cannot be accurately quantified. The incidence of hypoparathyroidism after total thyroidectomy has high variability in the literature, between 7 and 37%. Data from 78 patients who underwent total thyroidectomy with Tissue Dissection with Solution Injection (TDSI group) from December 2018 to August 2019 were retrospectively reviewed. These patients were compared with 78 patients to whom the technique was not applied (non-TDSI group), and they were treated from January 2018 to September 2018. All thyroidectomies were performed by the same surgeon. The mean duration of a thyroidectomy was 1 hour. The reduction of the incidence of postoperative hypoparathyroidism in the group of patients was applied in respect of the technique of tissue dissection with saline injection. TDSI technique paves the way for further application to other tissues and surgeries.
Cognitive preservation following awake mapping-based neurosurgery for low-grade gliomas: A longitudinal, within-patient design study
Authors: Lemaitre Anne-Laure , Herbet Guillaume , Ng Sam , Moritz-Gasser Sylvie , Duffau Hugues 
Published: November 2021

Abstract

Background
Awake surgery with intraoperative electrical mapping emerged as a gold-standard approach in newly diagnosed diffuse low-grade glioma (DLGG) to optimize the extent of resection (EOR) while sparing critical brain structures. However, no study has assessed to what extent cognitive recovery occurs following awake mapping-guided neurosurgery in a large, longitudinal, and homogeneous series of DLGG.

Methods
A longitudinal study on the cognitive status of 157 DLGG patients was performed. Neuropsychological assessments were done before and three months after awake mapping-based surgery. Z-scores and variations of Z-scores were computed to determine the number of patients with cognitive deficit(s) or decline. Clinical, surgical, and histopathological variables were studied to investigate factors contributing to neurocognitive outcomes.

Results
Eighty-seven patients (55.4%) had preoperative cognitive impairments. Statistical analysis between the preoperative (baseline) and postoperative assessments demonstrated a significant difference in three domains (Executive, Psychomotor Speed and Attention, Verbal Episodic Memory). Eighty-six percent of patients exhibited no postoperative cognitive decline, and among them, 10% exhibited cognitive improvement. The mean EOR was 92.3%±7.8%. The EOR, postoperative volume, and tumor lateralization had a significant association with cognitive decline. No patients demonstrated permanent postoperative neurologic deficits, but 5.8% did not resume their preoperative professional activities. The 5-year survival rate was 82.2%.

Conclusions
This is the largest series ever reported with systematic longitudinal neuropsychological assessment. 86% of patients demonstrated no cognitive decline despite large resections and only 5.8% did not return to work. This work supports the practice of awake surgery with cognitive mapping as safe and effective in DLGG patients.
Retail food outlets and metabolic syndrome: a systematic review of longitudinal studies
Authors: de Albuquerque Fernanda Martins , Pessoa Milene Cristine , De Santis Filgueiras Mariana , Gardone Danielle Soares , de Novaes Juliana Farias 
Published: November 2021

Abstract

Context
The community food environment covers the type, quantity, density, location, and access to retail food outlets, and its influence on eating behavior, obesity, and metabolic syndrome has been investigated.

Objective
To evaluate the evidence on longitudinal associations between objectively measured retail food outlets and metabolic syndrome components in children, adolescents, and adults.

Data extraction
This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Study quality and risk of bias were assessed with the Newcastle-Ottawa Scale.

Data sources
The Scopus, Embase, Web of Science, Scielo, PubMed, MEDLINE, and Lilacs databases were searched without any restriction on publication dates.

Data analysis
Of the 18 longitudinal studies included, significant associations were reported in 9 between retail food outlets and metabolic syndrome components in adults (6 positive associations, 2 negative, and 1 both positive and negative), and in 3 studies of children and adolescents (2 negative associations and 1 both positive and negative). Six studies with adults found no association.

Conclusion
Limited evidence was found for longitudinal associations between retail food outlets and metabolic syndrome components. In future studies, researchers should consider the use of standardized retail food outlet measurements and accurate analysis to better understand the influence of the community food environment on metabolic syndrome.

Systematic Review Registration
PROSPERO registration no: CRD42020177137.
Sequential use of niche and occupancy models identifies conservation and research priority areas for two data-poor endemic birds from the Colombian Andes
Authors: Botero-Delgadillo Esteban , Escudero-Páez Sandra , Sanabria-Mejía Jeyson , Caicedo Pilar , Bayly Nicholas J 
Published: November 2021

AbstractThe lack of high-quality information on data-poor species can hinder efforts to inform conservation actions via spatial distribution modeling. This is particularly true for tropical birds of conservation concern, for which ecological studies and assessments of their conservation status have received limited funding. Here we use a cost- and time-efficient protocol for assessing the distribution of range-restricted taxa and to identify priority areas for their conservation based on a sequential application of environmental niche models (ENMs) and occupancy-detection models. This approach first uses available geographical information and niche-theory to prioritize potential study sites, which can later be surveyed to obtain high-quality presence–absence data to accurately model distributional ranges with limited resources. We apply this protocol to identify priority areas for two Neotropical birds of conservation concern endemic to the Colombian Andes: Yellow-headed Brush-finch (Atlapetes flaviceps) and Tolima Dove (Leptotila conoveri). We first fitted ENMs using spatially filtered datasets containing all available records up to 2018. We then conducted field surveys across climatically suitable areas identified for both species, carrying out a total of 1,750 counts to generate input data for the occupancy models. Overall, our results suggested more extended and more continuous distribution ranges for both species than previously reported, but also identified population strongholds that are not currently represented within the national protected areas system. Both species occupied a narrow elevational belt (~1,300–2,600 m above sea level) of the Central Andes of Colombia primarily on the slopes of the Magdalena River valley, with isolated populations in the Western and Eastern Andes; these areas have undergone some of the most marked landscape transformations in Colombia. This straightforward protocol maximizes available information and minimizes costs, while allowing for estimation of occurrence probabilities for range-restricted, data-poor taxa.
Agency Deficits in a Human Genetic Model of Schizophrenia: Insights From 22q11DS Patients
Authors: Salomon Roy , Kannape Oliver Alan , Debarba Henrique Galvan , Kaliuzhna Mariia , Schneider Maude , Faivre Nathan , Eliez Stephan , Blanke Olaf 
Published: November 2021

Abstract
Schizophrenia is a chronic and disabling mental illness characterized by a disordered sense of self. Current theories suggest that deficiencies in the sense of control over one’s actions (Sense of Agency, SoA) may underlie some of the symptoms of schizophrenia. However, it is not clear if agency deficits are a precursor or a result of psychosis. Here, we investigated full body agency using virtual reality in a cohort of 22q11 deletion syndrome participants with a genetic propensity for schizophrenia. In two experiments employing virtual reality, full body motion tracking, and online feedback, we investigated SoA in two separate domains. Our results show that participants with 22q11DS had a considerable deficit in monitoring their actions, compared to age-matched controls in both the temporal and spatial domain. This was coupled with a bias toward erroneous attribution of actions to the self. These results indicate that nonpsychotic 22q11DS participants have a domain general deficit in the conscious sensorimotor mechanisms underlying the bodily self. Our data reveal an abnormality in the SoA in a cohort with a genetic predisposition for schizophrenia, but without psychosis, providing evidence that deficits in delineation of the self may be a precursor rather than a result of the psychotic state.
Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity
Authors: Hammond Sean , Olsson-Brown Anna , Grice Sophie , Gibson Andrew , Gardner Joshua , Castrejón-Flores Jose Luis , Jolly Carol , Fisher Benjamin Alexis , Steven Neil , Betts Catherine , Pirmohamed Munir , Meng Xiaoli , Naisbitt Dean John 
Published: November 2021

Abstract
An emerging clinical issue associated with immune-oncology agents is the collateral effects on the tolerability of concomitant medications. One report of this phenomenon was the increased incidence of hypersensitivity reactions observed in patients receiving concurrent immune checkpoint inhibitors (ICIs) and sulfasalazine (SLZ). Thus, the aim of this study was to characterize the T cells involved in the pathogenesis of such reactions, and recapitulate the effects of inhibitory checkpoint blockade on de-novo priming responses to compounds within in vitro platforms. A regulatory competent human dendritic cell/T-cell coculture assay was used to model the effects of ICIs on de novo nitroso sulfamethoxazole- and sulfapyridine (SP) (the sulfonamide component of SLZ) hydroxylamine-specific priming responses. The role of T cells in the pathogenesis of the observed reactions was explored in 3 patients through phenotypic characterization of SP/sulfapyridine hydroxylamine (SPHA)-responsive T-cell clones (TCC), and assessment of cross-reactivity and pathways of T-cell activation. Augmentation of the frequency of responding drug-specific T cells and intensity of the T-cell response was observed with PD-1/PD-L1 blockade. Monoclonal populations of SP- and SPHA-responsive T cells were isolated from all 3 patients. A core secretory effector molecule profile (IFN-γ, IL-13, granzyme B, and perforin) was identified for SP and SPHA-responsive TCC, which proceeded through Pi and hapten mechanisms, respectively. Data presented herein provides evidence that drug-responsive T cells are effectors of hypersensitivity reactions observed in oncology patients administered ICIs and SLZ. Perturbation of drug-specific T-cell priming is a plausible explanation for clinical observations of how an increased incidence of these adverse events is occurring.