bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bat Ant Lion Optimization-Based Generative Adversarial Network For Structural Heath Monitoring In IoT
Authors: S Yoganand , S Chithra 
Published: May 2021

Abstract
Attributable to the rapid growth of information technology, the Internet of Things (IoT) having strong permeability characteristics, huge usage of action and better comprehensive benefits. However, it encourages the development of IoT technology in the detection of structural engineering. Structural health monitoring (SHM) is responsible for identifying techniques and for prototyping systems performing a state diagnosis of structures. Its aim is to prevent sudden civil infrastructure failure as a result of several invisible sources of damage. This paper devises a novel method, namely bat-antlion Optimization dependent generative adversarial network (BALO-based GAN) for monitoring the states of structural health. Here, IoT nodes sense the signals of each channels and sensed data are transmitted to base station (BS) using Monarch-Earthworm (Monarch-EWA)-enabled secure routing protocol that selects the optimal path for the data transmission. After performing the IoT routing, the state of the structural health is monitored at the BS. For SHM, the input signal acquired from the IoT routing phase is fed to the pre-processing step for improving the signal quality for further processing. Then, the feature extraction is performed using fractional-amplitude modulation spectrogram (fractional AMS) for extracting the best features for improving the classification accuracy. The extracted features are adapted by the GAN, which is trained by BALO. The proposed BALO is newly designed by integrating the Bat algorithm and antlion optimizer. The proposed BALO-based GAN showed improved performance with maximal accuracy of 0.912, maximal sensitivity of 0.911, maximal throughput of 0.972 and maximal specificity of 0.913, respectively.
Prediction intervals reporting in orthodontic meta-analyses
Authors: Seehra Jadbinder , Stonehouse-Smith Daniel , Pandis Nikolaos 
Published: May 2021

SummaryBackgroundA prediction interval represents a clinical interpretation of heterogeneity. The aim of this study was to determine the prevalence of prediction interval reporting in orthodontic random effect meta-analyses. The corroboration between effect size estimates with 95% confidence intervals (CIs) and prediction intervals were also explored.Materials and methodsSystematic reviews (SRs) published between 1 January 2010 and 31 January 2021 containing at least one random effects meta-analysis (minimum of three trials) were identified electronically. SR and meta-analyses characteristics were extracted and prediction intervals, where possible, were calculated. Descriptive statistics and the percentage of meta-analyses where the prediction interval changed the interpretation based on the 95% CI were calculated. Fisher’s exact test was used to examine associations between the study variables and reporting of prediction intervals.ResultsOne hundred and twenty-one SRs were included. The median number of SR authors was 5 (interquartile range: 4–6). The reporting of prediction intervals was undertaken in only 19.0% (N = 23/121) of meta-analyses. Out of 95 meta-analyses, only in 6 (6.3%, N = 6/95) were the 95% CI corroborated by the prediction interval. In 60 meta-analyses (63.3%, N = 60/95) despite a 95% CI indicating a statistically significant result, this was not corroborated by the corresponding prediction interval.ConclusionsWithin the study timeframe, reporting of prediction intervals is not routinely undertaken in orthodontic meta-analyses possibly due to a lack of awareness. In future orthodontic random effects models containing a minimum of three trials, reporting of prediction intervals is advocated as this gives an indication of the range of the expected effect of treatment interventions.
Shaping healthy and sustainable food systems with behavioural food policy
Authors: Reisch Lucia A 
Published: May 2021

AbstractThis paper focuses on policies that are enlightened by behavioural insights (BIs), taking decision-makers’ biases and use of heuristics into account and utilising a people-centric perspective and full acknowledgement of context dependency. Considering both the environmental and pandemic crises, it sketches the goal of resilient food systems and describes the contours of behavioural food policy. Conceptually built on BIs derived from behavioural economics, consumer research and decision science, such an approach systematically uses behavioural policies where appropriate and most cost-effective. BI informed tools (nudges) can be employed as stand-alone instruments (such as defaults) or used to improve the effectiveness of traditional policy tools.
Endosperm and Seed Transcriptomes Reveal Possible Roles for Small RNA Pathways in Wild Tomato Hybrid Seed Failure
Authors: Florez-Rueda Ana Marcela , Fiscalini Flurin , Roth Morgane , Grossniklaus Ueli , Städler Thomas 
Published: May 2021

Abstract
Crosses between the wild tomato species Solanum peruvianum and Solanum chilense result in hybrid seed failure (HSF), characterized by endosperm misdevelopment and embryo arrest. We previously showed that genomic imprinting, the parent-of-origin–dependent expression of alleles, is perturbed in the hybrid endosperm, with many of the normally paternally expressed genes losing their imprinted status. Here, we report transcriptome-based analyses of gene and small RNA (sRNA) expression levels. We identified 2,295 genes and 387 sRNA clusters as differentially expressed when comparing reciprocal hybrid seed to seeds and endosperms from the two within-species crosses. Our analyses uncovered a pattern of overdominance in endosperm gene expression in both hybrid cross directions, in marked contrast to the patterns of sRNA expression in whole seeds. Intriguingly, patterns of increased gene expression resemble the previously reported increased maternal expression proportions in hybrid endosperms. We identified physical clusters of sRNAs; differentially expressed sRNAs exhibit reduced transcript abundance in hybrid seeds of both cross directions. Moreover, sRNAs map to genes coding for key proteins involved in epigenetic regulation of gene expression, suggesting a regulatory feedback mechanism. We describe examples of genes that appear to be targets of sRNA-mediated gene silencing; in these cases, reduced sRNA abundance is concomitant with increased gene expression in hybrid seeds. Our analyses also show that S. peruvianum dominance impacts gene and sRNA expression in hybrid seeds. Overall, our study indicates roles for sRNA-mediated epigenetic regulation in HSF between closely related wild tomato species.
HyRAD-X Exome Capture Museomics Unravels Giant Ground Beetle Evolution
Authors: Toussaint Emmanuel F A , Gauthier Jérémy , Bilat Julia , Gillett Conrad P D T , Gough Harlan M , Lundkvist Håkan , Blanc Mickael , Muñoz-Ramírez Carlos P , Alvarez Nadir 
Published: May 2021

AbstractAdvances in phylogenomics contribute toward resolving long-standing evolutionary questions. Notwithstanding, genetic diversity contained within more than a billion biological specimens deposited in natural history museums remains recalcitrant to analysis owing to challenges posed by its intrinsically degraded nature. Yet that tantalizing resource could be critical in overcoming taxon sampling constraints hindering our ability to address major evolutionary questions. We addressed this impediment by developing phyloHyRAD, a new bioinformatic pipeline enabling locus recovery at a broad evolutionary scale from HyRAD-X exome capture of museum specimens of low DNA integrity using a benchtop RAD-derived exome-complexity-reduction probe set developed from high DNA integrity specimens. Our new pipeline can also successfully align raw RNAseq transcriptomic and ultraconserved element reads with the RAD-derived probe catalog. Using this method, we generated a robust timetree for Carabinae beetles, the lack of which had precluded study of macroevolutionary trends pertaining to their biogeography and wing-morphology evolution. We successfully recovered up to 2,945 loci with a mean of 1,788 loci across the exome of specimens of varying age. Coverage was not significantly linked to specimen age, demonstrating the wide exploitability of museum specimens. We also recovered fragmentary mitogenomes compatible with Sanger-sequenced mtDNA. Our phylogenomic timetree revealed a Lower Cretaceous origin for crown group Carabinae, with the extinct Aplothorax Waterhouse, 1841 nested within the genus Calosoma Weber, 1801 demonstrating the junior synonymy of Aplothorax syn. nov., resulting in the new combination Calosoma burchellii (Waterhouse, 1841) comb. nov. This study compellingly illustrates that HyRAD-X and phyloHyRAD efficiently provide genomic-level data sets informative at deep evolutionary scales.
Specific heparan sulfate modifications stabilize the synaptic organizer MADD-4/Punctin at Caenorhabditis elegans neuromuscular junctions
Authors: Cizeron Mélissa , Granger Laure , Bülow Hannes E , Bessereau Jean-Louis 
Published: May 2021

Abstract
Heparan sulfate (HS) proteoglycans contribute to the structural organization of various neurochemical synapses. Depending on the system, their role involves either the core protein or the glycosaminoglycan chains. These linear sugar chains are extensively modified by HS modification enzymes, resulting in highly diverse molecules. Specific modifications of glycosaminoglycan chains may thus contribute to a sugar code involved in synapse specificity. Caenorhabditis elegans is particularly useful to address this question because of the low level of genomic redundancy of these enzymes, as opposed to mammals. Here, we systematically mutated the genes encoding HS modification enzymes in C. elegans and analyzed their impact on excitatory and inhibitory neuromuscular junctions (NMJs). Using single chain antibodies that recognize different HS modification patterns, we show in vivo that these two HS epitopes are carried by the SDN-1 core protein, the unique C. elegans syndecan ortholog, at NMJs. Intriguingly, these antibodies differentially bind to excitatory and inhibitory synapses, implying unique HS modification patterns at different NMJs. Moreover, while most enzymes are individually dispensable for proper organization of NMJs, we show that 3-O-sulfation of SDN-1 is required to maintain wild-type levels of the extracellular matrix protein MADD-4/Punctin, a central synaptic organizer that defines the identity of excitatory and inhibitory synaptic domains at the plasma membrane of muscle cells.
Magnetic radial inversion for 3-D source geometry estimation
Authors: Vital L B , Oliveira Jr. V C , Barbosa V C F 
Published: May 2021

SUMMARY
We present a method for inverting total-field anomaly data to estimate the geometry of a uniformly magnetized 3-D geological source in the subsurface. The method assumes the total-magnetization direction is known. We approximate the source by an ensemble of vertically juxtaposed right prisms, all of them with the same total-magnetization vector and depth extent. The horizontal cross-section of each prism is a polygon defined by a given number of equi-angularly spaced vertices from 0° to 360°, whose polygon vertices are described by polar coordinates with an origin defined by a horizontal location over the top of each prism. Because our method estimates the radii of each polygon vertex we refer to it as radial inversion. The position of these vertices, the horizontal location of each prism and the depth extent of all prisms are the parameters to be estimated by solving a constrained non-linear inverse problem of minimizing a goal function. We run successive inversions for a range of tentative total-magnetization intensities and depths to the top of the shallowest prism. The estimated models producing the lowest values of the goal function form the set of candidate solutions. To obtain stabilized solutions, we impose the zeroth- and first-order Tikhonov regularizations on the shape of the prisms. The method allows estimating the geometry of both vertical and inclined sources, with a constant direction of magnetization, by using the Tikhonov regularization. Tests with synthetic data show that the method can be of utility in estimating the shape of the magnetic source even in the presence of a strong regional field. Results obtained by inverting airborne total-field anomaly data over the Anitápolis alkaline–carbonatitic complex, in southern Brazil, suggest that the emplacement of the magnetic sources was controlled by NW–SE-trending faults at depth, in accordance with known structural features at the study area.
Optimal boundary control of Saint-Venant equations with arbitrary friction and space-varying slope
Authors: Wang Yang-Yang , Sun Bing 
Published: May 2021

Abstract
This paper is concerned with the optimal boundary control for the one-dimensional Saint-Venant equations with arbitrary friction and space-varying slope. By the Dubovitskii and Milyutin functional analytical approach, the Pontryagin maximum principles of the optimal control systems equipped with two boundary control variables are investigated and the first-order necessary optimality conditions are presented in both the fixed and the free final horizon cases, respectively. Finally, a remark on numerical solution is made for illustrating how to apply the obtained results to the investigational optimal boundary control problem.
Pragmatism in IR: The Prospects for Substantive Theorizing
Authors: Pratt Simon Frankel , Schmidt Sebastian , Avant Deborah , Cochran Molly , Jackson Patrick Thaddeus , Farrell Henry , Knight Jack , Hellmann Gunther 
Published: May 2021

Abstract
The contributors to this forum all draw significantly from pragmatist philosophy and social theory for making sense of international politics. Collectively, we affirm the value of pragmatist work beyond metatheory and methodology, both politically and epistemically—that is, as both a moral project and an explanatory one. Indeed, we are especially united on the notion that pragmatism “bridges” the divide between these things, and several contributors focus their discussion on how. However, we differ in what exactly it means to offer a distinctly pragmatist explanation or a “substantive” pragmatist theory, as well as in how pragmatism allows us to navigate the analytical and ethical challenges of the field. Over ten years ago, an earlier forum in this journal helped establish that pragmatism had something to offer; with over a decade of scholarship and reflection since, we revisit and expand on the question of how to deliver on it.
Using ethnographic methods to classify the human experience in medicine: a case study of the presence ontology
Authors: Maitra Amrapali , Kamdar Maulik R , Zulman Donna M , Haverfield Marie C , Brown-Johnson Cati , Schwartz Rachel , Israni Sonoo Thadaney , Verghese Abraham , Musen Mark A 
Published: May 2021

AbstractObjectiveAlthough social and environmental factors are central to provider–patient interactions, the data that reflect these factors can be incomplete, vague, and subjective. We sought to create a conceptual framework to describe and classify data about presence, the domain of interpersonal connection in medicine.MethodsOur top-down approach for ontology development based on the concept of “relationality” included the following: 1) a broad survey of the social sciences literature and a systematic literature review of &gt;20 000 articles around interpersonal connection in medicine, 2) relational ethnography of clinical encounters (n = 5 pilot, 27 full), and 3) interviews about relational work with 40 medical and nonmedical professionals. We formalized the model using the Web Ontology Language in the Protégé ontology editor. We iteratively evaluated and refined the Presence Ontology through manual expert review and automated annotation of literature.Results and DiscussionThe Presence Ontology facilitates the naming and classification of concepts that would otherwise be vague. Our model categorizes contributors to healthcare encounters and factors such as communication, emotions, tools, and environment. Ontology evaluation indicated that cognitive models (both patients’ explanatory models and providers’ caregiving approaches) influenced encounters and were subsequently incorporated. We show how ethnographic methods based in relationality can aid the representation of experiential concepts (eg, empathy, trust). Our ontology could support investigative methods to improve healthcare processes for both patients and healthcare providers, including annotation of videotaped encounters, development of clinical instruments to measure presence, or implementation of electronic health record-based reminders for providers.ConclusionThe Presence Ontology provides a model for using ethnographic approaches to classify interpersonal data.
Umbelliferone ameliorates oxidative stress and testicular injury, improves steroidogenesis and upregulates peroxisome proliferator-activated receptor gamma in type 2 diabetic rats
Authors: Allam Mohamed A M , Khowailed Akef A , Elattar Samah , Mahmoud Ayman M 
Published: May 2021

Abstract

Objectives
Diabetes mellitus (DM) is a chronic disease associated with serious complications, including male infertility. Umbelliferone (UMB) is a coumarin with promising antioxidant, anti-inflammatory and other beneficial effects. This study investigated the ameliorative effect of UMB against testicular injury, oxidative stress and altered steroidogenesis in rats with type 2 DM.

Methods
Rats received a high fat diet for 4 weeks followed by a single injection of streptozotocin. Diabetic rats were treated with UMB or pioglitazone (PIO) for 6 weeks and samples were collected for analysis.

Key findings
Diabetic rats exhibited hyperglycemia, insulin resistance and dyslipidemia associated with increased serum pro-inflammatory cytokines, and decreased gonadotropins and testosterone. UMB significantly ameliorated metabolic alterations, decreased pro-inflammatory cytokines, and increased gonadotropins and testosterone levels. UMB prevented testicular injury, suppressed lipid peroxidation and nitric oxide and increased antioxidants in diabetic rats. In addition, UMB upregulated testicular gonadotropins receptors, steroidogenesis markers (steroidogenic acute regulatory protein, cytochrome P450 family 17 subfamily A member 1 [CYP17A1], 3β-hydroxysteroid dehydrogenase [3ß-HSD] and 17ß-hydroxysteroid dehydrogenase [17ß-HSD]), and peroxisome proliferator-activated receptor gamma (PPARγ) expression.

Conclusions
UMB prevents testicular injury by preventing metabolic alterations, suppressing oxidative damage and inflammation, and boosting antioxidant defenses in diabetic rats. UMB enhanced pituitary-gonadal axis and steroidogenesis and upregulated testicular PPARγ in diabetic rats. Thus, UMB may represent a protective agent against testicular injury and sexual dysfunction associated with chronic hyperglycemia.
Determination of Vega’s rotational velocity based on the Fourier analysis of spectral line profiles
Authors: Takeda Yoichi 
Published: May 2021

ABSTRACT
While it is known that the sharp-line star Vega (vesin i ∼ 20 km s−1) is actually a rapid rotator seen nearly pole-on with low $i\, ({\lt}10^{\circ })$, no consensus has yet been accomplished regarding its intrinsic rotational velocity (ve), for which rather different values have been reported so far. Methodologically, detailed analysis of spectral line profiles is useful for this purpose, since they reflect more or less the ve-dependent gravitational darkening effect. However, direct comparison of observed and theoretically simulated line profiles is not necessarily effective in practice, where the solution is sensitively affected by various conditions and the scope for combining many lines is lacking. In this study, determination of Vega’s ve was attempted based on an alternative approach making use of the first zero (q1) of the Fourier transform of each line profile, which depends on K (temperature sensitivity parameter differing from line to line) and ve. It turned out that ve and vesin i could be separately established by comparing the observed $q_{1}^{\rm obs}$ and calculated $q_{1}^{\rm cal}$ values for a number of lines of different K. Actually, independent analysis applied to two line sets (49 Fe i lines and 41 Fe ii lines) yielded results reasonably consistent with each other. The final parameters of Vega’s rotation were concluded as vesin i = 21.6(±0.3) km s−1, ve = 195(±15) km s−1, and i = 6.4(±0.5)○.
Representativeness of systemic sclerosis patients in interventional randomized trials: an analysis of the EUSTAR database
Authors: Iudici Michele , Jarlborg Matthias , Lauper Kim , Müller-Ladner Ulf , Smith Vanessa , Allanore Yannick , Balbir-Gurman Alexandra , Doria Andrea , Airò Paolo , Walker Ulrich A , Riccieri Valeria , Vonk Madelon C , Gabrielli Armando , Hoffmann-Vold Anna-Maria , Szücs Gabriella , Martin Thierry , Distler Oliver , Courvoisier Delphine S ,   EUSTAR collaborators
Published: May 2021

Abstract

Objective
To estimate the extent of and the reasons for ineligibility in randomized controlled trials (RCTs) of SSc patients included in the EUSTAR database, and to determine the association between patient’s features and generalizability of study results.

Methods
We searched Clinicaltrials.gov for all records on interventional SSc-RCTs registered from January 2013 to January 2018. Two reviewers selected studies, and information on the main trial features were retrieved. Data from 8046 patients having a visit in the EUSTAR database since 2013 were used to check patient’s eligibility. The proportion of potentially eligible patients per trial, and the risk factors for ineligibility were analysed. Complete-, worst- and best-case analyses were performed.

Results
Of the 37 RCTs included, 43% were conducted in Europe, 35% were industry-funded, and 87% investigated pharmacological treatments. Ninety-one percent of 8046 patients included could have participated in at least one RCT. In complete-case analysis, the median [range] proportion of eligible patients having the main organ complication targeted by each study was 60% [10–100] in the overall sample of trials, ranging from 50% [32–79] for trials on skin fibrosis to 90% [34–77] for those targeting RP. Among the criteria checked, treatment- and safety-related but not demographic were the main barriers to patient’s recruitment. Older age, absence of RP, and lower mRSS were independently associated with the failure to fulfill criteria for any of the included studies.

Conclusions
Patient’s representativeness in SSc-RCTs is highly variable and is driven more by treatment- and safety-related rather than demographic criteria.