bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparison of Familial and Sporadic Type 1 Diabetes Among Young Patients
Authors: Karges Beate , Prinz Nicole , Placzek Kerstin , Datz Nicolin , Papsch Matthias , Strier Ursula , Agena Dirk , Bonfig Walter , Kentrup Heiner , Holl Reinhard W. 
Published: April 2021

OBJECTIVE
To investigate natural course, treatment, and outcomes in familial versus sporadic type 1 diabetes.

RESEARCH DESIGN AND METHODS
In a population-based study, we compared patients with onset of type 1 diabetes before the age of 20 years who had a first-degree relative with type 1 diabetes (familial diabetes) with patients with type 1 diabetes who had no first-degree relative with type 1 diabetes (sporadic diabetes) at diagnosis and over the first 10 treatment years, using multivariable regression and proportional hazards models. Patients were identified from the Diabetes Prospective Follow-up Registry (DPV) between 1995 and 2018.

RESULTS
Of 57,371 patients with type 1 diabetes, 53,606 (93.4%) had sporadic diabetes and 3,765 (6.6%) had familial diabetes. Familial diabetes, compared with sporadic diabetes, was associated with younger age (median 7.9 vs. 9.7 years, P &lt; 0.001), lower prevalence of ketoacidosis (11.9% vs. 20.4%, P &lt; 0.001), and lower HbA1c levels (9.7% vs. 11.1%, P &lt; 0.001) at onset and higher prevalence of associated autoimmune disease (16.7% vs. 13.6%, P &lt; 0.001). Over 10 years, patients with familial diabetes, in comparison with sporadic diabetes, more often used insulin pumps (P &lt; 0.001) and had a lower rate of severe hypoglycemia (12.97 vs. 14.44 per 100 patient-years, P &lt; 0.001) but similar HbA1c levels (P ≥ 0.08) and ketoacidosis rates (1.85 vs. 2.06 per 100 patient-years, P = 0.11). In familial and sporadic diabetes, absence of ketoacidosis at onset predicted fewer events of severe hypoglycemia (hazard ratio [HR] 0.67, P &lt; 0.001, and 0.91, P &lt; 0.001, respectively) and of ketoacidosis (HR 0.64, P = 0.007, and 0.66, P &lt; 0.001, respectively) after 10 years.

CONCLUSIONS
Familial type 1 diabetes, compared with sporadic type 1 diabetes, is characterized by earlier disease manifestation and higher autoimmune comorbidity as well as less metabolic decompensation at onset, likely related to higher disease awareness in affected families, while the course of disease is similar. These findings may have implications for the generalizability of results of diabetes prevention trials from patients with familial type 1 diabetes to patients with sporadic type 1 diabetes.
IDENTIFIKASI TRADISI MEGIBUNG PADA UPACARA DEWA YADNYA DI DESA BESAKIH DAN PENGENALANNYA MELALUI MEDIA YOUTUBE
Authors: Susilawati Ni Ketut 
Published: April 2021

ABSTRAKPenelitian ini bertujuan untuk : (1) mendeskripsikan serangkaian tradisi megibung mulai dari tahap persiapan, pengolahan hidangan, penyajian hidangan dan pelaksanaan megibung Di Desa Besakih, (2) memperkenalkan tradisi megibung di Desa Besakih melalui youtube. Jenis penelitian ini adalah penelitian deskriptif kualitatif. Teknik pengumpulan data menggunakan metode observasi, wawancara, dan dokumentasi. Instrumen penelitian mengunakan lembar observasi dan pedoman wawancara. Analisis data menggunakan teknik analisis deskriptif kualitatif. Hasil penelitian ini menunjukkan: (1) Tradisi megibung di Desa Besakih terdiri dari tahap persiapan, pengolahan hidangan, penyajian hidangan dan pelaksanaan megibung yang dilaksanakan dengan asas kekeluargaan dan gotong royong. Tahap persiapan meliputi persiapan bahan dan alat. Tahap pengolahan merupakan proses mengolah bahan makanan menjadi hidangan megibung. Hidangan yang disajikan terdiri dari nasi, olahan lawar yang meliputi lawar gecok, anyang, lawar belimbing, lawar jeruk dan lawar nangka, sate gede serta kuah trengtengan. Tahap penyajian terdiri dari gibungan yang diletakkan ditengah sele serta olahan lawar diletakkan disisi kanan dan kiri gibungan. Tahap pelaksanaan megibung, peserta duduk melingkar dengan etika tangan kanan mengadap ke gibungan dan berkhirnya acara setelah semua makanan selesai dinikmati. (2) Pengenalan tradisi megibung di Desa Besakih melaui youtube yaitu mendokumentasikan serangkaian acara megibung dengan menampilkan realita yang ada. Penggunaan teknologi menjadi fokus utama media pengenalan yaitu youtube popular youtube untuk mengunggah video via online, sehingga dapat memberikan dampak edukasi dan pengetahuan bagi masyarakat mengenai tradisi megibung yang perlu dijaga dan dilestarikan.
MODERN EXPERIENCE OF PARENTERAL NUTRITION WITH STANDARDIZED PREPARATIONS OF INDUSTRIAL PRODUCTION IN PEDIATRIC PRACTICE: LITERATURE REVIEW
Authors: Znamenska T. , Vorobiova O. , Marushko Y. 
Published: April 2021

Parenteral nutrition can save the lives of newborns and children who cannot receive adequate oral or enteral nutrition due to premature birth, functional immaturity, intestinal failure or inability to tolerate breastfeeding enterally due to congenital surgical pathology of the gastrointestinal tract, respiratory, cardiovascular and other. Pediatric patients, in particular infants with very low and extremely low birth weight, are particularly vulnerable to energy deficiency and protein restriction, which occurs immediately after birth and / or during periods of serious illness.
The aim ofthis work. Evaluate the current experience of using standardized drugs for parenteral nutrition in pharmacy and industrial production based on the analysis of the results of international clinical trials and published reviews in this regard.
Materials and methods. The results of 27 scientific publications were retrospectively analyzed with clear results of clinical randomized observations (case-control studies, prospective cohort studies, time series and retrospective data), multicenter studies, meta-analyzes and systematic reviews of the use of standardized drugs nutrition, industrial production: Numeta G13E, Numeta G16E of the company "Baxter" (USA), etc., also 1 systematic review of the management of "ready-to-use" drugs for parenteral nutrition in newborns. A review of data from scientometric Internet databases: Pub Med, UpToDate, Medscape EU, Medscape Pediatrics, etc.
Results. According to the literature, parenteral nutrition (PN) can be provided in the form of a standard mixture, currently mainly industrial production, which is designed to cover the nutritional needs of most patients of the same age group (pediatric, including neonatal) with a similar condition.
Conclusions. Standard solutions for PN can be safely used in most pediatric and neonatal patients, including preterm infants with very low birth weight, usually for the short period of time (up to 2-3 weeks) required by most children. In general, standardized parenteral nutrition should be preferred to individualized solutions in most pediatric patients and infants, including preterm infants with very low birth weight. The ready-to-use standardized industrial product has the potential to reduce the risk of infection, provide a sufficient supply of nutrients, ensure the child's growth within the expected range, is easy to use, reduces prescription errors and potentially reduces economic costs. The short- and long-term impact of its use in subsequent clinical trials should be evaluated.
Lived Experiences of End Stage Renal Disease Patients Undergoing Continuous Ambulatory Peritoneal Dialysis Therapy
Authors: 'Adhi M. Hanif Prasetya , Trisyani Yanny , Emaliyawati Etika 
Published: April 2021

End stage renal disease (ESRD) is a serious chronic disease that resulted from complications of chronic renal failure and a final diagnosis that requires treatment modalities such as dialysis or continuous ambulatory peritoneal dialysis (CAPD). However, CAPD is rarely selected as renal replacement therapy by ESRD patients in Indonesia. Therefore, the phenomenon associated with patients undergoing CAPD is unclear, especially in Indonesia. The purpose of this study was to explore the lived experiences of ESRD patients undergoing CAPD therapy. The research method employed qualitative descriptive phenomenology. The participants in this study were 10 ESRD patients with CAPD. Data collection utilized semi-structured interviewed and data was analyzed using the Colaizzi approach. The result of the study was explained through 6 themes. These are: 1) Condition improved with CAPD, 2) Freedom of activity, 3) Between feeling better and bored 4) Health is increased, 5) It is sustained life, 6) Resignation to accept illness. In conclusion, the patients with CAPD felt significant positive changes in their life and CAPD is considered life-sustaining for the participants, as the majority of the symptoms was decreased significantly. Therefore, the partisipants felt their conditions improved better. The unpleasant sides of CAPD are feeling bored. The support of the family is important as it produced strength and passion for patients in undergoing CAPD.
IMPLEMENTASI METODE TAMI OTAKA DALAM PEMBELAJARAN HAFALAN AL-QUR’AN DI TK PINTAR KOTA BANDUNG
Authors: Muhammad Sufyan As-Tsauri  
Published: April 2021

The purpose of this research is to see the implementation, evaluation, and advantages and disadvantages of the Tami Otaka Method. The Tami Otaka Method is a method of memorizing by using the ability of the right brain by means of the students memorizing the Qur’an while moving their hands from the verse they are reading. The type of research taken is field research using a qualitative approach. The object of this research is TK PINTAR Bandung, which includes the principal, tahfidz teacher, curriculum, and students. To obtain research data, researcher used observation, interview, and documentation techniques. This research uses descriptive qualitative analysis, so that the results of this study are manifested in the form of words both orally and verbally. The results obtained are as follows: first, to achieve purpose of the learning, TK PINTAR Bandung uses the Tami Otaka method with the help of audio, visual, audio-visual and body movements of a teacher. Second, the curriculum used is a synthesis of the National Curriculum and the Typical Curriculum of TK PINTAR Bandung. Third, learning is carried out in groups. Fourth, the evaluation is given continuously everyday and there is also an evaluation every semester.

Tujuan dari penelitian ini adalah untuk mengetahui pelaksanaan, penerapan, evaluasi serta kelebihan dan kekurangan dari Metode Tami Otaka. Metode Tami Otaka adalah Metode menghafal menggunakan kemampuan otak kanan dengan cara siswa menghafal Al-Qur’an sambil menggerakkan tangan dari arti ayat yang dibaca. Jenis penelitian yang diambil adalah penelitian lapangan dengan menggunakan pendekatan kualitatif. Objek penelitian ini adalah lembaga TK PINTAR Bandung yang di dalamnya ada kepala sekolah, guru tahfidz, kurikulum, dan siswa. Untuk memperoleh data penelitian, peneliti menggunakan teknik observasi, wawancara, dan dokumentasi. Penelitian ini menggunakan analisis kualitatif deskriptif, sehingga hasil dari penelitian ini diwujudkan dalam bentuk kata-kata baik tulisan maupun lisan. Hasil penelitian diperoleh sebagai berikut: pertama, untuk mencapai tujuan pembelajaran, TK PINTAR Bandung menggunakan metode Tami Otaka dengan dibantu media auido, visual, audio-visual dan gerakan tubuh dari seorang guru. Kedua, kurikulum yang digunakan sintesis dari kurikulum Nasional dan kurikulum khas TK PINTAR Bandung. Ketiga, pembelajaran dilakukan secara berkelompok. Keempat, evaluasi diberikan terus menerus setiap harinya dan ada juga evaluasi tiap semester.
A New Design and Epitopes Analysis for Recombinant Vaccine against Salmonella typhi by In silico Analysis
Authors: Bidmeshki Barzoki Tahereh , Ahadi Ali Mohammad , Ayat Hoda 
Published: April 2021

Nowadays, foodborne diseases are one of the main problems of the world that infect humans due to consumption of contaminated water or food. Typhoid fever is one of the major causes of illness and death in the world caused by Salmonella typhi. Vaccination is one of the most effective approaches in order to reduction of the disease risk. The main goal of this study is designing and characterization of antigenic determinants of a fusion protein originated from S.typhi usable as an effective vaccine. In this study, the outer membrane proteins of salmonella have been considered as candidates conferring protection against typhoid. Considering the evidence, OmpA, OmpF and OmpC proteins of salmonella applied in a multivalent vaccine design. Conserved motives of these proteins were selected using the CLC software and then their extracellular regions of these peptides were identified with PRED-TMBB server. Appropriate motives were combined for design of final fusion protein. Finally epitops of designed protein with high antigenic properties were identified using BCPREDS, Ellipro, ABCpred, EpiJen, NetCTL-1.2, CTLpred, TAPpred, ProPred and VaxiJen servers. Predicted designed protein in this study reached a very high scores for antigenic indexes. Encoding Genetic construction of this fusion protein could be applied for production of the recombinant OmpA.OmpF.OmpC derived fusion protein with effective antigenic properties as a new vaccine against S.typhi. Laboratory experiments and animal challenging analyses is ongoing.
Gastrointestinal Nematode Infections in Antelopes from Morocco: A Coprological Survey
Authors: Aissa Saidi , Rachida Mimouni , Fatima Hamadi , Widade Oubrou 
Published: April 2021

Abstract
This study examined the gastrointestinal parasitological status of three endangered Sub-Saharan antelope species (Addax nasomaculatus, Oryx dammah, Gazella dorcas) hosted at Souss-Massa National Park in Morocco. A total of 254 faecal samples (80 samples from the addax population, 81 from the oryx population and 93 from the dorcas population) were analysed to determine the prevalence and the intensity of the parasites in host faeces (expressed as the mean EPG: egg per gram), using microscopic methods (Flotation and McMaster) and the molecular identification of parasites using PCR and sequencing of the second internal transcribed spacer region of the rDNA (ITS-2).
The prevalence results in the addax, oryx and dorcas gazelle were 43.7%, 2.4%, and 61.3%, respectively, for Nematodirus spp.; 21.2%, 12.3%, and 16.13%, respectively, for Trichuris spp.; and 36.2%, 39.5%, and 53.7%, respectively, for other, undistinguished strongylids.
The means of EPG values for parasites in addax, oryx and dorcas gazelle were 8.9, 2.4, and 61.3, respectively, for Nematodirus spp.; 4.3, 2.4, and 4.8, respectively, for Trichuris spp.; and 18.1, 16.6, and 50.1, respectively, for other undistinguished strongylids. Sequencing of the ITS-2 rDNA region of the isolated parasites allowed the identification of Camelostrongylus mentulatus and Nematodirus spathiger in these three antelope species. We can conclude that the studied antelopes are infected at tolerating levels with the first record of Camelostrongylus mentulatus and Nematodirus spathiger in those antelopes in Morocco.
Traumatic Blepharitis Including Cutanous Changes with a Clinical Appearance of Immune-Mediated Disease
Authors: Helga Kecova , Natalija Milcic-Matic , Tatjana Lazic , Sinisa Grozdanic 
Published: April 2021

Abstract
A four-year-old intact male Labrador retriever was presented with acute onset of ulcerative lesions around both eyes, on the mucocutaneous junctions around the muzzle and nares, and on the lateral aspects of paw pads. All lesions were symmetrical and well demarcated. The rest of ocular and systemic examination was unremarkable. The onset of lesions was acute and coincided with an episode of intense hunting in switchgrass. Similar lesions were present in another dog used in the same hunting trip. The clinical presentation was suggestive of a possible immune-mediated skin disease. However, the patient responded to systemic antibiotic treatment with full recovery without recurrence upon cessation of therapy. Traumatic origin should be included into differential diagnosis of mucocutaneous ulcerative lesions presenting as a possible immune-mediated skin disease.
Silicon Titanium Oxide Nanoparticles Can Stimulate Plant Growth and the Photosynthetic Pigments on Lettuce Crop
Authors: Mariz-Ponte Nuno , Sario Sara , Mendes Rafael J. , Correia Cristiana V. , Moutinho-Pereira José , Correia Carlos M. , Santos Conceição 
Published: April 2021

Abstract
Our knowledge of the bioactivity of silicon titanium oxide nanoparticles (TiSiO4 NPs) in crops is scarce, contrarily to TiO2NPs and SiO2NPs that are used in many industrial sectors, and have emerged in nanoagriculture (e.g., as pesticides or nanofertilisers). To evaluate the potential of using TiSiO4 NPs in nanoagriculture, it is necessary to characterize their potential benefits on crops and the safety doses. Here, we report for the first time the bioactivity of TiSiO4 NPs (up to 100 mg/L) in the model crop lettuce (Lactuca sativa L.) exposed for three weeks (from seeds/seedlings to pre-harvesting phase). The doses applied did not compromise the germination rate, and highly stimulated plant fresh matter. TiSiO4 NPs had beneficial effects on photochemical processes by increasing chlorophyll levels. Effects on photosynthesis are less evident but TiSiO4 NPs (100 mg/L) stimulated the photosynthetic potential, increasing Fv/Fm and ETR when compared to the 50 mg/L conditions. TiSiO4 NPs did not influence the net photosynthetic rate and other Calvin-cycle variables. Soluble sugars and starch levels were overall maintained. In general, this first report on TiSiO4 NPs bioactivity suggests that they did not have a toxic effect, and may be used to potentiate crops’ growth. Principal component analysis (PCA) also shows that despite effects on photosynthetic performance is minimal regarding the control, the 50 and 100 mg/L doses strongly differ, with the lower dose promoting mostly pigment accumulation, while the higher dose slightly stimulates Photosystem II efficiency including the electron transport rate and other gas exchange parameters.
Experimental Estimation of Wear Resistance of Polyamide Composites, Reinforced By Carbon and Glass Fibres Used in Metal-Polymer Gearings
Authors: Chernets Myron , Kindrachuk Myroslav , Kornienko Anatolii , Yurchuk Alina 
Published: April 2021

Abstract
The method of model triboexperimental studies to determine the basic mathematical model parameters of materials wear resistance at sliding friction is considered. The quantitative relative experimental characteristics of wear resistance of glass fibre and carbon fibre reinforced polyamide used in metal-polymer gear couple have been determined. Wear resistance functions of these functional polymeric composites have been established as the basic ones in the tribokinetic mathematical model of material wear for sliding friction conditions. Also, according to the conducted researches, wear resistance diagrams were constructed. They may be used as graphical indicators of wear resistance in the required range of specific friction forces. The dependences that connect the characteristic functions of wear resistance of these materials (obtained by the developed mathematical tribokinetic wear model) with linear wear and gearing service life are presented.
Investigating the impacts of artificial intelligence technology on technological innovation from a patent perspective
Authors: Qiu Yi-Hui , Yang Xin , Li Zong-Ze , Zhang Chiyu , Chen Shui-Xuan 
Published: April 2021

Abstract
Artificial intelligence (AI) technology has been widely applied in various fields in recent years. Nevertheless, no systematic study has yet been conducted on the effects of AI technology on different fields. In this study, the impacts of the latest AI technology on technological innovation in different fields were analysed and quantized systematically from a patent perspective. Moreover, trends on AI technological innovation in some fields were analysed thoroughly. We conducted this study on a dataset of patents related to AI technology. Based on the patent dataset, we carried out a statistical analysis on technology fields, which we defined and classified based on international patent classification (IPC) number. Distributions of IPC in different fields were also analysed to determine the trends on AI technological innovation. The research conclusions can provide useful information to investors and enterprises, who are interested in the state of the art concerning AI technology.
A Note on the Asymptotic Behavior of the Distribution Function of a General Sequence
Authors: Farhadian Reza , Jakimczuk Rafael 
Published: April 2021

Abstract
The aim of this note is to study the distribution function of certain sequences of positive integers, including, for example, Bell numbers, factorials and primorials. In fact, we establish some general asymptotic formulas in this regard. We also prove some limits that connect these sequences with the number e. Furthermore, we present a generalization of the primorial.
Gaps and preliminary perspectives concerning innovation infrastructure in the Carpathian Countries
Authors: Andrei Coca , Petruța Blaga 
Published: April 2021

Abstract
Innovation, although still an emerging concept in terms of development policies, is no longer abstract, being defined, measured and assessed by performance indicators, thus managing to shape the global economy and also entrepreneurial dynamics at territorial level. Using as main source of documentation the “Global Innovation Index 2020” Report, this paper seeks to highlight by using quantitative statistical methods the innovation performance of the Parties of the Carpathian Convention with a deep focus on innovation infrastructure, measured by 10 performance indicators.
A Single Institution Experience in Hypertrofic Pyloric Stenosis
Authors: Toth Tamas , Prişcă Ana-Maria , Borda Angela , Gozar Horea , Prişcă Radu-Alexandru 
Published: April 2021

Abstract
The most common causes of non-bilious vomiting in infants are hypertrophic pyloric stenosis and pylorospasm. Differential diagnosis between the pathologies establishes the correct treatment. The aim of our study is to present the management of the pathologies cured in our department. The longer the duration of vomiting symptoms the higher muscle thickness was shown. Dehydration and lethargy was associated with higher muscle thickness. There were no intraoperative or postoperative complications recorded in our cases. Ultrasonography is the gold standard in imaging technique but it requires an experienced radiologist. In case of negative physical examination and ultrasonography, but high suspicion of the diagnosis a fluoroscopy may be required. The correct diagnosis avoids unnecessary surgery combined with general anesthesia.
Incomplete Kawasaki Disease: What Can We Do About It?
Authors: Dobrotă Luminiţa , Cazan Corina , Bratu Dan-Vladimir , Neamţu Bogdan 
Published: April 2021

Abstract
Kawasaki disease is a rare condition that mainly affects children younger than 6 years old. However, it represents the most common cause of acquired heart disease and the second most frequent vasculitis in children. Its importance consists in cardiac (coronary) complications identified in adults younger than 40 years old. Early diagnosis is pivotal for preventing (or reducing) coronary aneurysms and avoiding, at least, later unnecessary surgical interventions. Full (classic, complete) Kawasaki disease is easily diagnosed, even if the symptoms are not always present at the same time and most of them are unspecific. Incomplete Kawasaki disease implies challenge, delay or misdiagnosis. “Picking it up early is a winner” – the specialists say, so that early treatment administered at the right moment can stop the inflammatory process leading to much better outcomes, consequently.