bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in Trophic Structure of An Exploited Fish Community At The Centennial Scale Are Linked To Fisheries and Climate Forces
Authors: Durante Leonardo , Wing Stephen , Ingram Travis , Sabadel Amandine , Shima Jeffrey 
Published: August 2021

Abstract
Understanding how marine food webs are affected by anthropogenic stressors is an important steppingstone toward the improved management of natural resources. Stable isotope analysis of historical and modern samples spanning a century indicated that the niche breadth of an exploited fish community increased after the expansion of New Zealand fisheries. Since the 2000s most species increased their reliance on food webs supported by pelagic production and shifted to a higher trophic level. Overall changes were coincident with ocean warming, climate oscillations, prey abundance and fishing intensity, but their effects were specific to each fish assemblage analyzed. Data derived from historical samples revealed how anthropogenic stressors can drive long-term shifts in the trophic structure of an exploited fish community.
Correlated interlayer exciton insulator in double layers of monolayer WSe2 and moiré WS2/WSe2
Authors: Zhang Zuocheng , Regan Emma , Wang Danqing , Zhao Wenyu , Wang Shaoxin , Sayyad Mohammed , Yumigeta Kentaro , Watanabe Kenji , Taniguchi Takashi , Tongay Sefaattin , Crommie Michael , Zettl Alex , Zaletel Michael , Wang Feng 
Published: August 2021

Abstract
Moiré superlattices in van der Waals heterostructures have emerged as a powerful tool for engineering novel quantum phenomena. Here we report the observation of a correlated interlayer exciton insulator in a double-layer heterostructure composed of a WSe2 monolayer and a WS2/WSe2 moiré bilayer that are separated by an ultrathin hexagonal boron nitride (hBN). The moiré WS2/WSe2 bilayer features a Mott insulator state at hole density p/p0 = 1, where p0 corresponds to one hole per moiré lattice site. When electrons are added to the Mott insulator in the WS2/WSe2 moiré bilayer and an equal number of holes are injected into the WSe2 monolayer, a new interlayer exciton insulator emerges with the holes in the WSe2 monolayer and the electrons in the doped Mott insulator bound together through interlayer Coulomb interactions. The excitonic insulator is stable up to a critical hole density of ~ 0.5p0 in the WSe2 monolayer, beyond which the system becomes metallic. Our study highlights the opportunities for realizing novel quantum phases in double-layer moiré systems due to the interplay between the moiré flat band and strong interlayer electron interactions.
Urinary pH is An Independent Predictor of Upper Tract Recurrence in Non-Muscle-Invasive Bladder Cancer Patients with a Smoking History
Authors: Ide Hiroki , Kikuchi Eiji , Ogihara Koichiro , Niwa Naoya , Shigeta Keisuke , Masuda Tsukasa , Baba Yuto , Mizuno Ryuichi , Oya Mototsugu 
Published: August 2021

Abstract
Limited information is currently available on predictors of upper tract urothelial carcinoma (UTUC) recurrence in non-muscle-invasive bladder cancer (NMIBC) patients according to smoking history, although smoking probably contributes to urothelial carcinogenesis. Therefore, the present study aimed to identify independent predictors of UTUC recurrence in all patients and those with a smoking history. Our study population comprised 1190 NMIBC patients who underwent transurethral resection of bladder tumor. UTUC developed in 43 patients during the follow-up. A history of bacillus Calmette-Guérin (BCG) therapy was independently associated with a lower incidence of UTUC (HR=0.43; P=0.011). In a subgroup of NMIBC patients with a smoking history, concomitant carcinoma in situ (CIS) and a lower urinary pH (<6) were independently associated with a higher incidence of UTUC recurrence (HR=3.34, P=0.006 and HR=3.73, P=0.008, respectively). Among patients with a longer smoking duration (≥20 years) or larger smoking intensity (≥20 cigarettes per day), those with lower urinary pH (<6) had a significantly higher UTUC recurrence rate than their counterparts. These results suggest that BCG instillation may prevent UTUC recurrence in NMIBC patients, while a lower urinary pH and concomitant CIS increase the risk of UTUC recurrence in those with a smoking history.
Impact of Radial Compression Protocols on Radial Artery Occlusion and Hemostasis Time
Authors: Takamatsu Sachiko , Kagiyama Nobuyuki , Sone Naohiko , Tougi Kiyotaka , Yamauchi Shuichiro , Yuri Takuya , Ii Nobuhisa , Sugimoto Tomoko , Masutani Motomaru , Hirohata Atsushi 
Published: August 2021

Abstract
Protocols for hemostasis after trans-radial approach (TRA) vary depending on the institute as there is no established evidence-based protocol. This study aimed to investigate the clinical implications of radial compression protocols. Consecutive patients who underwent outpatient invasive catheter angiography before and after April 2018 were treated with traditional and new protocols, respectively. Using the same hemostasis band, the amount and timing of deflation were fixed in the traditional protocol, whereas the air was removed as much as possible every 30 min in the new protocol. A total of 1,842 patients (71±10 years old, 77% male) were included. Compared with the traditional protocol group (n=1,001), the new protocol group (n=841) had a significantly lower rate of dual antiplatelet therapy (24% vs. 35%, p<0.001). The time required for complete hemostasis was approximately one-third with the new protocol (66±32 min vs. 190±16 min, p<0.001) with no clinically relevant bleeding. The incidence of radial artery occlusion (RAO) was 9.8% and 0.9% in the traditional and new protocol groups, respectively (p<0.001). After adjusting for covariates, the new protocol was associated with a shorter hemostasis time (odds ratio 0.01, p<0.001) and a reduced risk of RAO (odds ratio 0.09, p<0.001). Our new protocol for hemostasis after TRA was strongly associated with a shorter hemostasis time and a lower rate of RAO.
Intraseasonal variability of global land monsoon precipitation and recent change
Authors: Liu Fei , Wang Bin , Ouyang Yu , Wang Hui , Qiao Shaobo , Chen Guosen , Dong Wenjie 
Published: August 2021

Abstract

Accurate prediction of global land monsoon rainfall on a subseasonal (2–8 weeks) time scale has become a worldwide demand. However, the current forecasts of weekly-mean rainfall in most monsoon regions have limited skills beyond two weeks. Given that two-thirds of the world’s population lives in the monsoon regions, this challenge calls for a more profound understanding of monsoon intraseasonal variability (ISVs). We show that the high-frequency (HF; 8–20 days) ISV, crucial for the Week 2 and Week 3 predictions, accounts for about 53–70% of the total (8–70 days) ISV in various land monsoon regions. The low-frequency (LF; 20–70 days) ISV has a relatively high contribution over Australia (47%), South Asia (43%), and South America (40%). The leading modes of HFISVs in Northern Hemisphere monsoons primarily originate from convectively coupled equatorial Rossby waves (Asia), mixed Rossby-gravity waves (North America), and Kelvin waves (West Africa), while in Southern Hemisphere monsoons, from mid-latitude wave trains. The Madden-Julian Oscillation (MJO) directly regulates LFISVs in the Asian-Australian monsoon while affecting the American and African monsoons by exciting Kelvin waves and mid-latitude teleconnections. During the past four decades, the HF (LF) ISVs have considerably intensified over the Asian (Asian-Australian) monsoon but weakened over the American (South American) monsoon. The presented characteristics of the ISV in each monsoon region are helpful for empirical subseasonal prediction and for identifying models’ strengths and weaknesses in reproducing regional monsoon ISVs. The results suggest an urgent need to improve the simulation of convectively coupled equatorial waves and two-way interactions between regional monsoon ISVs and mid-latitude processes and between MJO and regional monsoons.
Van der Pol Model in Two-Delay Differential Equation Representation
Authors: Elfouly M. A. , Sohaly M. A. 
Published: August 2021

Abstract
The Van der Pol equation is the mathematical model of a second-order ordinary differential equation with cubic nonlinearity. In this paper, the differential equation of the Van der Pol model and RLC (resistor - inductor-capacitor) circuit are deduced from a delay differential equation. The Van der Pol delay model contains two delays, which opens the way for the re-use of its applications. Also, the model for Parkinson's disease modification is described as the Van der Pol model.
Controllable Chiral Self-sorting and Guest Recognition of Ultra-stable Axially Chiral Porous Aromatic Cages
Authors: Cui Dongxu , Geng Yun , Kou Junning , SHAN Guogang , Sun Chun-Yi , Wang Xinlong , Su Zhong-Min 
Published: August 2021

Abstract
The synthesis of ultra-stable chiral porous organic cages (POCs) and their controllable chiral self-sorting at the molecular and supramolecular level is still a daunting challenge. Herein, we report the design and synthesis of a serial of axially chiral porous aromatic cages (1-S and 1-R) with exceptional chemical stability. The theoretical and experimental studies on chiral self-sorting reveal that the exclusive self-recognition on cage formation is an enthalpy-driven process while the chiral narcissistic and social self-sorting on supramolecular assembly of racemic cages can be precisely regulated by π–π and C–H…π interactions from different solvents. Moreover, the crystallinity of 1 can be preserved under various harsh conditions including boiling water, and high-concentrated acid and alkali solutions. Further investigations on chiral sensing show that 1 possesses high enantioselectivity toward axially chiral aromatic racemates.
cPLA2 Blockade Attenuates S100A7-Mediated Breast Tumorigenicity by Inhibiting the Immunosuppressive Tumor Microenvironment
Authors: MISHRA SANJAY , Charan Manish , Shukla Rajni Kant , Agarwal Pranay , Misri Swati , Verma Ajeet K , Ahirwar Dinesh K , Siddiqui Jalal , Kaul Kirti , Sahu Neety , Vyas Kunj , Garg Ayush Arpit , Khan Anum , Miles Wayne O , Song Jonathan W , Bhutani Nidhi , Ganju Ramesh K 
Published: August 2021

Abstract
Background: Metastasis is the major cause of mortality in breast cancer; however, the molecular mechanisms remain elusive. In our previous study, we demonstrated that S100A7/RAGE mediates breast cancer growth and metastasis by recruitment of tumor-associated macrophages. However, the downstream S100A7-mediated inflammatory oncogenic signaling cascade that enhances breast tumor growth and metastasis by generating the immunosuppressive tumor microenvironment (iTME) has not been studied. In this present study, we aimed to investigate the S100A7 and cPLA2 cross-talk in enhancing tumor growth and metastasis through enhancing the iTME.Methods: Human breast cancer tissue and plasma samples were used to analyze the expression of S100A7, cPLA2, and PGE2 titer. S100A7-overexpressing or downregulated human metastatic breast cancer cells were used to evaluate the S100A7-mediated downstream signaling mechanisms. Bi-transgenic mS100a7a15 overexpression, TNBC C3(1)/Tag transgenic, and humanized patient-derived xenograft mouse models and cPLA2 inhibitor (AACOCF3) were used to investigate the role of S100A7/cPLA2/PGE2 signaling in tumor growth and metastasis. Additionally, CODEX, a highly advanced multiplexed imaging was employed to delineate the effect of S100A7/cPLA2 inhibition on the recruitment of various immune cells.Results: S100A7 and cPLA2 are highly expressed and positively correlated in malignant breast cancer patients. S100A7/RAGE upregulates cPLA2/PGE2 axis in aggressive breast cancer cells. Furthermore, S100A7 is positively correlated with PGE2 in breast cancer patients. Moreover, cPLA2 pharmacological inhibition suppressed S100A7-mediated tumor growth and metastasis in multiple pre-clinical models. Mechanistically, S100A7-mediated activation of cPLA2 enhances the recruitment of immunosuppressive myeloid cells by increasing PGE2 to fuel breast cancer growth and its secondary spread. We revealed that cPLA2 inhibitor mitigates S100A7-mediated breast tumorigenicity by suppressing the iTME. Furthermore, CODEX imaging data showed that cPLA2 inhibition increased the infiltration of CD4+/CD8+ T cells in the TME. Analysis of metastatic breast cancer samples revealed a positive correlation between S100A7/cPLA2 with CD163+ tumor-associated M2-macrophages.Conclusions: Our study shows that cross-talk between S100A7 and cPLA2 plays an important role in enhancing breast tumor growth and metastasis by generating an immunosuppressive tumor microenvironment and reducing infiltration of T cells. Furthermore, S100A7 could be used as a novel non-invasive prognostic marker and cPLA2 inhibitors as promising drugs against S100A7-overexpressing metastatic breast cancer.
Numerical Simulation and Rapid Centrifugal Casting of Large Complex Thin-Walled Titanium Alloy Intermediate Casing Based on 3D Printed Pattern
Authors: Li Shurong , Wang Yingchun , Zhang Xiao , Xian Quangang , Zhao Yanjie , Qi Chengkang , Li Zhihui , Lai Junhua , Li Fei 
Published: August 2021

Abstract
Titanium alloy intermediate casing is a typical large casting, with many thin-walled and complex structures. It is a high cost and time-consuming process in the trial stage to manufacturing the wax pattern of the intermediate casing by metal mold. Rapid investment casting based on 3D printed patterns is the development direction of casting technology which integrates digitization and intelligence. In this study, selective laser sintering (SLS) technology was used to realize the rapid prototyping of polystyrene pattern in the precision casting of intermediate casing. A numerical simulation method was used to predict the filling process, solidification and casting defects of the intermediate casing. The simulation results show that the gating system for the casting of intermediate casting was reasonable, the number and size of gating risers met the open design requirements, and a sequential solidification of the casting could be realized. The titanium alloy intermediate casing with excellent metallurgical quality and size accuracy CT7 was successfully produced using centrifugal rapid casting technology.
Secretory pathway Ca-ATPase 2 (SPCA2) gene knockout results in mouse mammary gland changes and a secretory defect
Authors: Reinhardt Timothy , Lippolis John , Palmer Mitchell 
Published: August 2021

Abstract
Calcium influx into the basolateral mammary cell is thought to be due partly to an unconventional partnering of SPCA2 and the calcium channel protein ORAI1 in vitro. ORAI1’s role in mammary secretory cell calcium influx, in support of milk calcium, has been confirmed in ORAI1 knockout (KO) mice. We examine the role of SPCA2 on mammary cell calcium influx in support of milk calcium concentration in SPCA2 KO mice. The SPCA2 KO resulted in a significant 40% reduction in milk calcium and a 57% reduction in milk manganese concentrations. The loss of SPCA2 was associated with a significant 55% increase in SPCA1, which may be compensatory. The expression of other calcium transporters/channels such as PMCA2/NHERF1, ORAI1, NCX1, and TMEM165 were not affected by the loss of SPCA2. Histologically SPCA2 KO mammary glands showed increased adiposity and altered structure. Milk production was significantly down in SPCA2 KO mice, but milk fat, protein, and lactose were unaffected. The significant decline in milk calcium in SPCA2 KO mice indirectly supports the SPCA2 role as an ORAI1 partner in calcium influx into mammary tissue. Further, studies will be required to clarify this relationship between SPCA2, ORAI1, and STIM1 on mammary calcium influx in vivo.
An Autophagy-related lncRNA Prognostic Risk Model for Thyroid Cancer
Authors: Shan Yanan , He Ran , Yang Xiaowei , Zang Siwen , Yao Shan , Gao Min , Li Sixuan , Yin Zhihua 
Published: August 2021

Abstract
Thyroid cancer (TC) is the most common malignancy of the endocrine system and its incidence is gradually rising. Research has demonstrated a close link between autophagy and thyroid cancer. We constructed a prognostic model of autophagy-related long noncoding RNA (lncRNA) in thyroid cancer and explored its prognostic value. A total of 14,142 lncRNAs and 212 autophagy-related genes (ATGs) were obtained from the Cancer Genome Atlas (TCGA) database and the Human Autophagy Database (HADb), respectively. We performed lncRNA-ATGs correlation analysis and finally obtained 1166 autophagy-associated lncRNAs. Subsequently we conducted univariate Cox regression analysis and multivariate Cox regression analysis, a nine-autophagy-related lncRNAs (AC092279.1, AC096677.1, DOCK9-DT, LINC02454, AL136366.1, AC008063.1, AC004918.3, LINC02471, AL162231.2) significantly associated with prognosis was identified. Based on these autophagy-related lncRNAs, a risk model was constructed. The area under the curve (AUC) of the risk score was 0.905, proving that the accuracy of risk signature was superior. In addition, multiple regression analysis showed that risk score was a significant independent prognostic risk factor for thyroid cancer. In this study, a nine autophagy-related lncRNAs in thyroid cancer were established to predict the prognosis of thyroid cancer patients.
Effect of Clonal Testing on the Efficiency of Genomic Evaluation in Forest Tree Breeding
Authors: Stejskal Jan , Klápště Jaroslav , Čepl Jaroslav , El-Kassaby Yousry A. , Lstibůrek Milan 
Published: August 2021

Abstract
Through stochastic simulations, accuracies of breeding values and response to selection were assessed under traditional pedigree- (BLUP) and genomic-based evaluation methods (GBLUP) in forest tree breeding. The latter provides a methodological foundation for genomic selection. We evaluated the impact of clonal replication in progeny testing on the response to selection realized in seed orchards under variable marker density and target effective population sizes. We found that clonal replication in progeny trials boosted selection accuracy, thus provided additional genetic gains under BLUP. While a similar trend was observed for GBLUP, however, the added gains did not surpass those under BLUP. Therefore, breeding programs deploying extensive progeny testing with clonal propagation might not benefit from the deployment of genomic information. These findings could be helpful in the context of operational breeding programs.
Cenozoic Relative Movements of Greenland and North America by Closure of the North Atlantic-arctic Plate Circuit: the Labrador Sea, Davis Strait and Baffin Bay
Authors: Causer Annabel , Eagles Graeme , Pérez-Díaz Lucía , Adam Jürgen 
Published: August 2021

Abstract
The processes that accommodated plate divergence between Greenland and North America are most confidently interpretable from a short-lived (61-42 Ma) sequence of magnetic isochrons in the Labrador Sea. Understanding of the preceding and following periods is impeded by the lack of clear isochrons in the basin’s continent-ocean transition and axial zones. By closing the regional plate circuit, we build and interpret a detailed plate motion model for Greenland and North America that is applicable in, but unaffected by data uncertainty from, the Labrador Sea, Davis Strait, and Baffin Bay. Among our findings, we show the Labrador Sea initially opened during a ~8.3-16.5 Myr-long period of focused extension culminating in continental breakup no earlier than 74-72 Ma, and experienced a ~80° change in spreading direction around 56 Ma. We describe some possible implications for the accommodation of strain prior to continental breakup and during extreme spreading obliquity.
Shaping the future of temperate forests in Europe: why outdoor recreation matters
Authors: Giergiczny Marek , Jacobsen Jette , Glenk Klaus , Meyerhoff Jürgen , Abildtrup Jens , Agimass Fitalew , Czajkowski Mikołaj , Faccioli Michela , Gajderowicz Tomasz , Getzner Michael , Lundhede Thomas , Mayer Marius , McVittie Alistair , Olschewski Roland , Ščasný Milan , Strange Niels , Valasiuk Sviataslau 
Published: August 2021

Abstract
Forests play a fundamental role in the economy, in climate change mitigation and in halting the loss of biodiversity. The economic value of goods and services provided to the societies by forests, including forest-based recreation, is highly dependent on the way in which forests are managed. On a European scale, forests are diverse and managed in many ways. Yet there has been no large-scale assessment to date of the economic value of forests recreation across Europe. In this paper we systematically apply stated and revealed preference-based valuation methods to investigate public preferences for forest visits in ten European countries (Austria, Belarus, Czech Republic, Denmark, France, Germany, Poland, Slovakia, Scotland, Switzerland). We observe substantial recreational value measured by the consumer surplus ranging from €55 to €648 per person per year (PPP adjusted, 2017). Compared to the gross value added of forestry and timber production, gross recreational benefits are, except for Belarus, on par or larger. Additionally, we find that forests of particular characteristics – more complex forest structures and forests with taller and older trees – are preferred and generate higher recreational values. These results provide a robust basis for evaluating the societal consequences of future forest management policies in Europe and the design of its forest landscapes.
Impacts of Offshore Wind Farms On The Atmospheric Environment Over Taiwan Strait During An Extreme Weather Typhoon Event
Authors: Lee Tsung-Yu , Wu Yu-Ting , Lin Chuan-Yao , Lin Yi-Ying , Sheng Yang-Fan 
Published: August 2021

Abstract
Wind energy is one of the cleanest renewable resources. Through the “Thousand Wind Turbines Project”, Taiwan is planning to increase the proportion of power generation from renewable energy and has set a target of 5.7 GW for offshore wind by 2025. However, the effects of future offshore wind farms (OWFs) over the Taiwan Strait on the atmospheric environment have not been evaluated. This study examined the potential effects of proposed OWFs on the atmospheric environment if the OWFs had existed during Tropical Storm Haitang (July 30–31, 2017) by using the Weather Research and Forecasting (WRF) model. As Tropical Storm Haitang made landfall in southern Taiwan and moved northward, wake effects formed at downstream of the OWFs and weather parameters were affected at the coastal area of western Taiwan. A significant reduction (as high as 6.1 %) in 24-hour accumulated precipitation was found over the western plain of Taiwan. Concurrently, the divergence increased, corresponding to a reduction in wind speed, vertical velocity, moisture flux, reflectivity and precipitable water–vapor (PWV), whereas a slight warming of near-surface air occurred. Sensitivity simulations demonstrated that the influence of OWF location and wind turbine density should not be ignored.