bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening for depression in children and adolescents: a protocol for a systematic review update
Authors: Beck Andrew , LeBlanc John C. , Morissette Kate , Hamel Candyce , Skidmore Becky , Colquhoun Heather , Lang Eddy , Moore Ainsley , Riva John J. , Thombs Brett D. , Patten Scott , Bragg Heather , Colman Ian , Goldfield Gary S. , Nicholls Stuart Gordon , Pajer Kathleen , Potter Beth K. , Meeder Robert , Vasa Priya , Hutton Brian , Shea Beverley J. , Graham Eva , Little Julian , Moher David , Stevens Adrienne 
Published: January 2021

Abstract
Background
Major depressive disorder is common, debilitating, and affects feelings, thoughts, mood, and behaviors. Childhood and adolescence are critical periods for the development of depression and adolescence is marked by an increased incidence of mental health disorders. This protocol outlines the planned scope and methods for a systematic review update that will evaluate the benefits and harms of screening for depression in children and adolescents.

Methods
This review will update a previously published systematic review by Roseman and colleagues. Eligible studies are randomized controlled trials (RCTs) assessing formal screening in primary care to identify children or adolescents not already self-reporting symptoms of, diagnosed with, or treated for depression. If no or only a single RCT is available, we will consider controlled studies without random assignment. Studies of participants with characteristics associated with an elevated risk of depression will be analyzed separately. Outcomes of interest are symptoms of depression, classification of major depressive disorder based on a validated diagnostic interview, suicidality, health-related quality of life, social function, impact on lifestyle behavior (e.g., substance use, school performance, lost time at work, or school), false-positive results, overdiagnosis, overtreatment, labeling, and other harms such as those arising from treatment. We will search MEDLINE, Embase, PsycINFO, CINAHL, the Cochrane Library, and grey literature sources. Two reviewers will independently screen the titles and abstracts using the liberal accelerated method. Full-text screening will be performed independently by two reviewers using pre-specified eligibility criteria. Data extraction and risk of bias assessments will be performed independently by two reviewers. Pre-planned analyses, including subgroup and sensitivity analyses, are detailed within this protocol. Two independent reviewers will assess and finalize through consensus the certainty of evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach, and prepare GRADE evidence profiles and summary of findings tables for each outcome of interest.

Discussion
The systematic review will provide a current state of the evidence of benefits and harms of depression screening in children and adolescents. These findings will be used by the Canadian Task Force on Preventive Health Care to inform the development of recommendations on depression screening.

Systematic review registration
PROSPERO CRD42020150373
Time delay induced Hopf bifurcation in a diffusive predator–prey model with prey toxicity
Authors: Yang Ruizhi , Ma Yuxin , Zhang Chiyu 
Published: January 2021

AbstractIn this paper, we consider a diffusive predator–prey model with a time delay and prey toxicity. The effect of time delay on the stability of the positive equilibrium is studied by analyzing the eigenvalue spectrum. Delay-induced Hopf bifurcation is also investigated. By utilizing the normal form method and center manifold reduction for partial functional differential equations, the formulas for determining the property of Hopf bifurcation are given.
Modified homotopy methods for generalized fractional perturbed Zakharov–Kuznetsov equation in dusty plasma
Authors: Akinyemi Lanre , Şenol Mehmet , Huseen Shaheed N. 
Published: January 2021

AbstractWe propose a new modification of homotopy perturbation method (HPM) called the δ-homotopy perturbation transform method (δ-HPTM). This modification consists of the Laplace transform method, HPM, and a control parameter δ. This control convergence parameter δ in this new modification helps in adjusting and controlling the convergence region of the series solution and overcome some limitations of HPM and HPTM. The δ-HPTM and q-homotopy analysis transform method (q-HATM) are considered to study the generalized time-fractional perturbed $(3+1)$
(
3
+
1
)
-dimensional Zakharov–Kuznetsov equation with Caputo fractional time derivative. This equation describes nonlinear dust-ion-acoustic waves in the magnetized two-ion-temperature dusty plasmas. The selection of an appropriate value of δ in δ-HPTM and the auxiliary parameters n and ħ in q-HATM gives a guaranteed convergence of series solution, but the difference between the two techniques is that the embedding parameter p in δ-HPTM varies from zero to nonzero δ, whereas the embedding parameter q in q-HATM varies from zero to $\frac{1}{n}, n\geq{1}$

1
n

,
n
≥
1
. We examine the effect of fractional order on the considered problem and present the error estimate when compared with exact solution. The outcomes reveal complete reliability and efficiency of the proposed algorithm for solving various types of physical models arising in sciences and engineering. Furthermore, we present the convergence and error analysis of the two methods.
A service-learning experience in a free medical centre for undocumented migrants and homeless people
Authors: Civitelli Giulia , Liddo Marica , Mutta Irene , Maisano Bianca , Tarsitani Gianfranco , Marceca Maurizio , Cedeno Gonzalo Castro , Geraci Salvatore 
Published: January 2021

Abstract
Background
Service-learning experiences, informed by the realities of poverty and marginalization, are important for the education of future health professionals in order to commit them to tackling health inequalities and working with underserved populations. At the Caritas Medical Centre for undocumented migrants and homeless in Rome, students obtain an educational experience of service. The aim of this study is to try to measure the long-term impact of this experience on the professional and life choices of the student participants.

Methods
A questionnaire was designed and distributed by email to all 19–29 years old participants in the experience. Responses were collected and analysed in a quantitative descriptive way and in a qualitative way using the knowledge, skills and attitudes model.

Results
One hundred and seven students responded from the total 763 questionnaires distributed. Ninety-five percent of participants expressed a very high overall satisfaction, 93% declared that the experience influenced his/her future personal choices, and 84% found that the experience influenced their professional choices. Results were arranged into 6 categories of comments: knowledge about the realities of migration, poverty, and marginalization; relational skills; collaborative skills; attitudes towards migrants, poor people and others; Attitudes towards future professions; Attitudes towards life. A final category was listed with self-reflective questions related to the experience.

Conclusion
This research shows the importance of service-learning experiences made during academic studies from young students of medicine and other faculties. Developing a relationship with marginalized and homeless people, within a voluntary service setting, can influence the future professional and personal choices of students. Universities should recognize the value of such experiences and establish partnerships with non-profit organizations to allow future health professionals to confront health inequities and commit themselves to their reduction.
Antiplatelet effect of cudraxanthone B is related to inhibition of calcium mobilization, αIIbβ3 activation, and clot retraction
Authors: Shin Jung-Hae , Irfan Muhammad , Rhee Man Hee , Kwon Hyuk-Woo 
Published: January 2021

AbstractCudrania tricuspidata (C. tricuspidata) is widespread throughout Asia and has known to have various physiological activities such as, inflammation, diabetes, obesity and tumor. Cudrania tricuspidata, a rich source of xanthones and flavonoids, have been investigated phytochemically and biologically. However, research of these compounds on platelets is limited. Therefore, we searched for a new substance from various xanthones and flavonoids in C. tricuspidata. We confirmed the results that steppogenin and isoderrone suppress human platelets among the various components isolated from C. tricuspidata, and as a result of analyzing the antiplatelet effect using additional new samples, we found that cudraxanthone B (CXB) has the effect of suppressing human platelets. Therefore, we studied the potential efficacies of CXB on human platelet aggregation and its inhibitory mechanism. Inhibitory effects of CXB on platelet aggregation were assessed using washed platelets, followed by measurement of [Ca2+]i mobilization and dense granule release, fibrinogen binding, fibronectin adhesion assay, and clot retraction. Our data showed that CXB suppressed collagen-induced human platelet aggregation, [Ca2+]i mobilization, fibrinogen binding, fibronectin adhesion and clot retraction without cytotoxicity. Thus, our results show that inhibitory effects of CXB on human platelet activation and thrombus formation, suggesting its potential use as a natural substance for preventing platelet-induced thrombosis.
Producing a village input–output table (VIOT) from household survey data: a case study of a VIOT for a rural village in northern Lao PDR
Authors: Hongsakhone Soulixay , Islam Moinul , Ichihashi Masaru 
Published: January 2021

AbstractIn this study, a village input–output table (VIOT) is built from household survey data from a rural village in a developing country to capture the interdependency between households through their transactions in 2016. This VIOT is a simple, but useful tool for understanding the economic transactions among villagers. The main findings of this work are that lower- and middle-income households mainly depend on commodities supplied by non-poor counterparts, especially by four higher-income households, who are not only producers, but also traders of commodities in the village and play key roles in the village economy, and that the IO interdependency among non-poor households is stronger than that among poor households. Additionally, this paper describes a first trial application of the VIOT method to develop economic policies with goals such as poverty reduction and trade expansion in the village.
Assessing the impact of watershed land use on Kebena river water quality in Addis Ababa, Ethiopia
Authors: Asnake Kalkidan , Worku Hailu , Argaw Mekuria 
Published: January 2021

Abstract
Background
The impact of watershed land-use on surface water quality is one of the under researched areas in mega cities of the developing countries like Addis Ababa. The study examined the impact of watershed land uses on the Kebena river water quality within its seasonal and spatial variation and assessed the relationship between river water pollution and dominant land-use types in the sub-watersheds.

Method
The main land use types in the sub-watersheds were digitized from aerial photograph of 2016, and quantified for water quality impact analysis. Water samples were collected from the main Kebena river and the three sub-watersheds source and outlet points. A total of 128 samples were collected during the dry and wet seasons of 2016 and 2017 and analyzed for various water quality parameters. The study employed ANOVA, independent t-tests and multiple regression analysis to examine variations in water quality and assess the influence of the different land uses on water quality.

Results
Forest, built-up area and cultivated lands are the three major land use types in the Kebena watershed accounting for 39.14, 32.51 and 27.25% of the total area, respectively. Kebena catchment is drained by three sub-watersheds namely, Denkaka (44.9% cultivated land), Little-Kebena (60.87% forested) and Ginfle (90.44% urban land). The concentration of pollutants in the Kebena river was significantly higher (P < 0.001) in the dry season than in the wet season. However, when compared to surface water quality standards, both the dry and wet season water quality records are exceptionally high. The urban and forest dominated sub-watersheds contribute significantly high amount of (P < 0.001) pollutant loads to the river which is associated with high runoff from impervious surfaces and sewerage discharge to the river from nearby urban settlements.

Conclusion
Integrating watershed planning with land use planning is of paramount importance to address water quality problems in urban areas. Thus, in the urban dominated sub-catchment, land-use planning should aim to relocating river front communities, providing sufficient river buffer-zones and forwarding appropriate storm water management schemes. In the forested sub-catchment, planning should protect, retain and enhance the existing natural green spaces through open space planning, and management schemes while providing wide river-buffer with natural vegetation cover to minimize pollution load to urban rivers from agriculture dominated sub-watershed.
Perception of Impacts of Climate Variability on Pastoralists and Their Adaptation/Coping Strategies in Fentale District of Oromia Region, Ethiopia
Authors: Mekuyie Muluken , Mulu Desta 
Published: January 2021

AbstractClimate change has been threatening pastoral communities in Ethiopia as their economy is mainly based on rain-fed agriculture. The study area is one of the climate change prone area affected by climate induced shocks. To reduce the adverse effects of climate change, pastoral households need to recognize the changes already happening in their climate and employ climate change adaptation measures. Therefore, the present study was conducted in Fentale district, Central Ethiopia to determine the perceived adverse impacts of climate change and variability, the perception of pastoral households on the patterns of climate change and variability, and identify the adaptation/coping strategies of pastoralists to climate change impacts. A household questionnaire survey and focus group discussion were employed to collect primary data at a household level. A total of 130 pastoral households were sampled using random sampling. The data collected from household survey were analyzed using SPSS (version 20). The rainfall and temperature trends of the study area were analysed using Mann–Kendall test. The findings indicated significant decreasing trend of Belg rainfall and increasing trend of Kiremt rainfall for the period 1983–2017. The perception of pastoral households on rainfall and temperature trends was in line with the results of the recorded meteorological data analysis of the present study except the Kiremt rainfall and the long-term annual rainfall trends. The results indicated that pasture and water availability became scarce and livestock assets and productivity were highly reduced, due to adverse impacts of climate change and variability. The most important strategies deployed by the local people included (i) integrating livestock with crop production, (ii) livestock mobility, (iii) livestock diversification and herd composition change, (iv) decreased consumption, (v) remittance, (vi) cash for work and (vii) food aid. Therefore, the government should support and enhance household’s indigenous adaptation strategies through the provision of market access, early warning information, affordable credit access, and development of water points.
MicroRNA bta-miR-365-3p inhibits proliferation but promotes differentiation of primary bovine myoblasts by targeting the activin A receptor type I
Authors: Hao Dan , Wang Xiaogang , Wang Xiao , Thomsen Bo , Yang Yu , Lan Xianyong , Huang Yongzhen , Chen Hong 
Published: January 2021

Abstract
Background
MicroRNAs act as post-transcriptional regulators that repress translation or degrade mRNA transcripts. Each microRNA has many mRNA targets and each mRNA may be targeted by several microRNAs. Skeletal muscles express a plethora of microRNA genes that regulate muscle development and function by controlling the expression of protein-coding target genes. To expand our understanding of the role of microRNA, specifically bta-miR-365-3p, in muscle biology, we investigated its functions in regulating primary bovine myoblast proliferation and differentiation.

Results
Firstly, we found that bta-miR-365-3p was predominantly expressed in skeletal muscle and heart tissue in Chinese Qinchuan beef cattle. Quantitative PCR and western blotting results showed that overexpression of bta-miR-365-3p significantly reduced the expression levels of cyclin D1 (CCND1), cyclin dependent kinase 2 (CDK2) and proliferating cell nuclear antigen (PCNA) but stimulated the expression levels of muscle differentiation markers, i.e., MYOD1, MYOG at both mRNA and protein level. Moreover, downregulation of bta-miR-365-3p increased the expression of CCND1, CDK2 and PCNA but decreased the expression of MYOD1 and MYOG at both mRNA and protein levels. Furthermore, flow cytometry, EdU proliferation assays and immunostaining results showed that increased levels of bta-miR-365-3p suppressed cell proliferation but promoted myotube formation, whereas decreased levels of bta-miR-365-3p resulted in the opposite consequences. Finally, we identified that activin A receptor type I (ACVR1) could be a direct target of bta-miR-365-3p. It was demonstrated that bta-miR-365-3p can bind to the 3’UTR of ACVR1 gene to regulate its expression based on dual luciferase gene reporter assays. Consistently, knock-down of ACVR1 was associated with decreased expressions of CDK2, CCND1 and PCNA but increased expression of MYOG and MYOD1 both at mRNA and protein level.

Conclusion
Collectively, these data suggested that bta-miR-365-3p represses proliferation but promotes differentiation of bovine myoblasts through several biological mechanisms involving downregulation of ACVR1.
Low-dosage ozonation in gas-phase biofilter promotes community diversity and robustness
Authors: Yeung Marvin , Saingam Prakit , Xu Yang , Xi Jinying 
Published: January 2021

AbstractBackgroundThe ozonation of biofilters is known to alleviate clogging and pressure drop issues while maintaining removal performances in biofiltration systems treating gaseous volatile organic compounds (VOCs). The effects of ozone on the biofilter microbiome in terms of biodiversity, community structure, metabolic abilities, and dominant taxa correlated with performance remain largely unknown.MethodsThis study investigated two biofilters treating high-concentration toluene operating in parallel, with one acting as control and the other exposed to low-dosage (200 mg/m3) ozonation. The microbial community diversity, metabolic rates of different carbon sources, functional predictions, and microbial co-occurrence networks of both communities were examined.ResultsConsistently higher biodiversity of over 30% was observed in the microbiome after ozonation, with increased overall metabolic abilities for amino acids and carboxylic acids. The relative abundance of species with reported stress-tolerant and biofilm-forming abilities significantly increased, with a consortium of changes in predicted biological pathways, including shifts in degradation pathways of intermediate compounds, while the correlation of top ASVs and genus with performance indicators showed diversifications in microbiota responsible for toluene degradation. A co-occurrence network of the community showed a decrease in average path distance and average betweenness with ozonation.ConclusionMajor degrading species highly correlated with performance shifted after ozonation. Increases in microbial biodiversity, coupled with improvements in metabolizing performances of multiple carbon sources including organic acids could explain the consistent performance commonly seen in the ozonation of biofilters despite the decrease in biomass, while avoiding acid buildup in long-term operation. The increased presence of stress-tolerant microbes in the microbiome coupled with the decentralization of the co-occurrence network suggest that ozonation could not only ameliorate clogging issues but also provide a microbiome more robust to loading shock seen in full-scale biofilters.
Restoration of non-structural damaged murals in Shenzhen Bao’an based on a generator–discriminator network
Authors: Li Jiao , Wang Huan , Deng Zhiqin , Pan Mingtao , Chen Honghai 
Published: January 2021

Abstract
Shenzhen is a modern metropolis, but it hides a variety of valuable cultural heritage, such as ancient murals. How to effectively preserve and repair the murals is a worthy of discussion question. Here, we propose a generation-discriminator network model based on artificial intelligence algorithms to perform digital image restoration of ancient damaged murals. In adversarial learning, this study optimizes the discriminative network model. First, the real mural images and damaged images are spliced together as input to the discriminator network. The network uses a 5-layer encoder unit to down-sample the 1024 × 1024 × 3 image to 32 × 32 × 256. Then, we connect a layer of ZeroPadding2D to expand the image to 34 × 34 × 256, and pass the Conv2D layer, down-sample to 31 × 31 × 256, perform batch normalization, and repeat the above steps to get a 30 × 30 × 1 matrix. Finally, this part of the loss is emphasized in the loss function as needed to improve the texture detail information of the image generated by the Generator. The experimental results show that compared with the traditional algorithm, the PSNR value of the algorithm proposed in this paper can be increased by 5.86 db at most. The SSIM value increased by 0.13. Judging from subjective vision. The proposed algorithm can effectively repair damaged murals with dot-like damage and complex texture structures. The algorithm we proposed may be helpful for the digital restoration of ancient murals, and may also provide reference for mural restoration workers.
Left and right ventricular longitudinal strains are associated with poor outcome in COVID-19: a systematic review and meta-analysis
Authors: Wibowo Arief , Pranata Raymond , Astuti Astri , Tiksnadi Badai Bhatara , Martanto Erwan , Martha Januar Wibawa , Purnomowati Augustine , Akbar Mohammad Rizki 
Published: January 2021

AbstractBackgroundThis systematic review and meta-analysis aimed to assess whether ventricular longitudinal strain can be used as a prognostication tool in patients with coronavirus disease 2019 (COVID-19).MethodsSystematic literature searches of PubMed, Embase, and EuropePMC databases were performed on 16 November 2020. Left ventricular global longitudinal strain (LV-GLS) refers to LV contraction measurement using the speckle tracking-based method refers to the mean of strain values of the RV free wall (three segments) measured using echocardiography. The main outcome was poor outcome, defined as a composite of mortality and severe COVID-19.ResultsSeven studies comprising of 612 patients were included in meta-analysis. Six studies have mortality as their outcome, and 1 study has severity as their outcome. Patients with poor outcome have lower LV-GLS (SMD 1.15 (0.57, 1.72),p< 0.001;I270.4%). Each 1% decrease in LV-GLS was associated with 1.4x increased risk of poor outcome (OR 1.37 (1.12, 1.67),p= 0.002;I248.8%). Patients with poor outcome have lower RV-LS (SMD 1.18 (0.91, 1.45),p< 0.001;I20%). Each 1% decrease in RV-LS was associated with 1.3x increased risk of poor outcome (OR 1.25 (1.15, 1.35),p< 0.001;I211.8%). Subgroup analysis showed that for every 1% decrease in LV-GLS and RV-LS is increased mortality with OR of 1.30 (1.12, 1.50) and OR of 1.24 (1.14, 1.35), respectively.ConclusionThis study shows that lower LV-GLS and RV-LS measurements were associated with poor outcome in patients with COVID-19.Trial registrationPROSPEROCRD42020221144