bluuebunny/crossref_metadata_2025_split huggingface dataset:
Steroid treatment for the first episode of childhood nephrotic syndrome: comparison of the 8 and 12 weeks regimen using an individual patient data meta-analysis
Authors: Schijvens Anne M. , Teeninga Nynke , Dorresteijn Eiske M. , Teerenstra Steven , Webb Nicholas J. , Schreuder Michiel F. 
Published: March 2021

AbstractSteroids are the cornerstone of the treatment of childhood nephrotic syndrome. The optimal duration for the first episode remains a matter of debate. The aim of this study is to determine whether the 8 weeks International Study of Kidney Disease in Children (ISKDC) regimen is equally effective as the 12 weeks steroid regimen from the German society of pediatric nephrology (Arbeitsgemeinschaft für Pädiatrische Nephrologie [APN]). An individual patient data (IPD) meta-analysis of randomized controlled trials reporting on prednisolone treatment for a first episode of childhood nephrotic syndrome was conducted. European trials aimed at investigating the ISKDC and/or APN steroid regimen were selected. The lead investigators of the selected trials were requested to provide the IPD of the specific treatment groups. Four trials included European cohorts using dosing schedules according to the regimens studied. IPD of two trials were available. A significant difference was found in time to first relapse after cessation of steroid treatment between the 8 and 12 weeks treatment group with a median time to relapse of 29 and 63 days, respectively. Moreover, relapse rate ratios during total follow-up were 51% higher for the 8 weeks regimen. Finally, younger children have a significantly lower time to first relapse and frequently relapsing nephrotic syndrome.Conclusions: The results of this IPD meta-analysis suggest that the 8 weeks steroid regimen for a first episode of steroid-sensitive nephrotic syndrome may not be equally effective as the 12 weeks steroid regimen. Moreover, this study highlights the importance of using uniform definitions to enable accurate comparison and interpretation of trial results.Trial registration: Registration number: CRD42020199244, date of registration 16-08-2020

What is Known:• Steroids are the cornerstone of the treatment of childhood nephrotic syndrome, however the optimal duration for the first episode remains a matter of debate.• Currently, the 8 weeks ISKDC protocol and 12 weeks APN protocol are among the most frequently used protocols in Europe.

What is New:• The 8 weeks steroid regimen for a first episode of steroid-sensitive nephrotic syndrome may not be equally effective as the 12 weeks steroid regimen for the treatment of a first episode of nephrotic syndrome.• Younger children have a significantly shorter time to first relapse and time to frequent relapsing nephrotic syndrome.
Metabolic activity of hydro-carbon-oxo-borate on a multispecies subgingival periodontal biofilm: a short communication
Authors: Shibli Jamil Awad , Rocha Thayane Furtado , Coelho Fernanda , de Oliveira Capote Ticiana Sidorenko , Saska Sybele , Melo Marcelo A. , Pingueiro João Marcos Spessoto , de Faveri Marcelo , Bueno-Silva Bruno 
Published: March 2021

Abstract
Objective
This study evaluated the metabolic activity of hydro-carbon-oxo-borate complex (HCOBc) on a multispecies subgingival biofilm as well as its effects on cytotoxicity.

Materials and methods
The subgingival biofilm with 32 species related to periodontitis was formed in the Calgary Biofilm Device (CBD) for 7 days. Two different therapeutic schemes were adopted: (1) treatment with HCOBc, 0.12% chlorhexidine (CHX), and negative control group (without treatment) from day 3 until day 6, two times a day for 1 min each time, totaling 8 treatments and (2) a 24-h treatment on a biofilm grown for 6 days. After 7 days of formation, biofilm metabolic activity was determined by colorimetry assay, and bacterial counts and proportions of complexes were determined by DNA-DNA hybridization. Both substances’ cytotoxicity was evaluated by cell viability (XTT assay) and clonogenic survival assay on ovary epithelial CHO-K1 cells and an osteoblast precursor from calvaria MC3T3-E1 cells.

Results
The first treatment scheme resulted in a significant reduction in biofilm’s metabolic activity by means of 77% by HCOBc and CHX treatments versus negative control. The total count of 11 and 25 species were decreased by treatment with hydro-carbon-oxo-borate complex and CHX, respectively, compared with the group without treatment (p < 0.05), highlighting a reduction in the levels of Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia, and Fusobacterium periodontium. CHX significantly reduced the count of 10 microorganisms compared to the group treated with HCOBc (p < 0.05). HCOBc and CHX significantly decreased the pathogenic red-complex proportion compared with control-treated biofilm, and HCOBc had even a more significant effect on the red complex than CHX had (p ≤ 0.05). For the second treatment scheme, HCOBc complex and CHX significantly decreased 61 and 72% of control biofilms’ metabolic activity and the counts of 27 and 26 species, respectively. HCOBc complex did not significantly affect the proportions of formed biofilms, while CHX significantly reduced red, orange, and yellow complexes. Both substances exhibited similar cytotoxicity results.

Conclusions
This short communication suggested that the HCOBc complex reduced a smaller number of bacterial species when compared to chlorhexidine during subgingival biofilm formation, but it was better than chlorhexidine in reducing red-complex bacterial proportions. Although HCOBc reduced the mature 6-day-old subgingival multispecies biofilms, it did not modify bacterial complexes’ ratios as chlorhexidine did on the biofilms mentioned above. Future in vivo studies are needed to validate these results.

Clinical relevance
HCOBc complex could be used to reduce red-complex periodontal bacterial proportions.
Assessing Facial Symmetry and Attractiveness using Augmented Reality
Authors: Wei Wei , Ho Edmond S. L. , McCay Kevin D. , Damaševičius Robertas , Maskeliūnas Rytis , Esposito Anna 
Published: March 2021

AbstractFacial symmetry is a key component in quantifying the perception of beauty. In this paper, we propose a set of facial features computed from facial landmarks which can be extracted at a low computational cost. We quantitatively evaluated the proposed features for predicting perceived attractiveness from human portraits on four benchmark datasets (SCUT-FBP, SCUT-FBP5500, FACES and Chicago Face Database). Experimental results showed that the performance of the proposed features is comparable to those extracted from a set with much denser facial landmarks. The computation of facial features was also implemented as an augmented reality (AR) app developed on Android OS. The app overlays four types of measurements and guidelines over a live video stream, while the facial measurements are computed from the tracked facial landmarks at run time. The developed app can be used to assist plastic surgeons in assessing facial symmetry when planning reconstructive facial surgeries.
Garry oak ecosystem stand history in Southwest British Columbia, Canada: implications of environmental change and indigenous land use for ecological restoration and population recovery
Authors: Barlow Celeste M. , Pellatt Marlow G. , Kohfeld Karen E. 
Published: March 2021

AbstractIn the Pacific Northwest of North America, endangered Garry oak ecosystems have a complex history that integrates effects of Holocene climate change, Indigenous land management, and colonial settlement during the Anthropocene. In western Canada, Garry oak and Douglas fir recruitment corresponds with the end of the Little Ice Age (LIA; ca. 1870), after the collapse of Indigenous populations but in some cases prior to European settlement. We examined establishment patterns at three sites in southwest British Columbia, each with different edaphic characteristics based on slope, exposure, and drainage. At our Somenos Marsh site on Vancouver Island, we see a clear relationship between Indigenous occupation, subsequent European settlement, and development of an oak woodland, indicating that Indigenous land management was important for development of many Garry oak ecosystems. However, at the Tumbo Cliff site (Tumbo Island, BC), shallow soil xeric conditions, regional climate, and periodic fire were likely drivers of stand and ecosystem development. Finally, at the deep soil Tumbo Marsh site, Garry oak established and grew quickly when conditions were favorable, following the early twentieth century conversion of a saltwater tidal flat into a freshwater marsh. Combining site level historical records, site characteristics, and dendrochronological data provides a greater understanding of the local and regional factors that shape the unique structures of Garry oak ecosystems at each site. This information can be integrated into restoration and fire management strategies for Garry oak ecosystems as well as elucidate the timing of European settler and climate change impacts on these ecosystems.
Evaluation of the role of staphylococci in the pathomechanism of conjunctivitis
Authors: Jasińska Ewa , Bogut Agnieszka , Magryś Agnieszka , Olender Alina 
Published: March 2021

Abstract
Purpose
Determination of the association between ica genes and phenotypic biofilm formation in staphylococcal isolates involved in conjunctivitis, their antibiotic resistance as well as detection of selected virulence characteristics: adhesion to epithelial cells and in vitro cytotoxicity.

Methods
The study included 26 Staphylococcus aureus (SA) and 26 Staphylococcus epidermidis (SE) isolates. The presence of icaAD genes and ica operon was determined by the PCR assay. Phenotypic biofilm formation was verified using the microtitre plate assay. Antibiotic resistance was performed using the disc diffusion method. Staphylococcal ability to attach to host cells was assessed by flow cytometry. Cytotoxicity on epithelial cells was evaluated by LDH assay.

Results
The ica genes were detected in 26.9% of SE and in 42.3% of SA isolates. Only 15.3% of isolates (SE) were positive for both the icaAD and the ica operon. Phenotypically, 19.2% of SE isolates were strong biofilm producers, among which three were both icaAD- and ica operon-positive. About 26.9% of SA isolates were strong biofilm producers. Methicillin resistance (MR) was detected in 34.6% of SE and 26.9% of SA isolates. About 75% of MR isolates were multidrug resistant. SA isolates adhered to host cells more extensively than SE. SA isolates released higher level of LDH than SE.

Conclusions
Adherence abilities were commonly observed in staphylococci associated with conjunctivitis. However, low prevalence of isolates positive for a complete and functional ica locus and low prevalence of strong biofilm producers was detected. SA adhered to a greater extent to eukaryotic cells than SE and were more cytotoxic.
Low-temperature sintered Ni–Zn–Co–Mn–O spinel oxide ceramics for multilayer NTC thermistors
Authors: Reimann Timmy , Töpfer Jörg 
Published: March 2021

AbstractThe phase formation, sintering behavior and electrical properties of Ni–Co–Zn–Mn spinel NTC thermistor ceramics of the series Ni0.5ZnzCo0.5Mn2−zO4 with 0 ≤ z ≤ 1 were studied. In contrast to NiMn2O4, which exhibits limited stability in air below 730 °C and above 970 °C, the Zn–Co-substituted nickel manganite spinels are stable at T < 730 °C and decompose at Td > 900 °C, with Td increasing with decreasing Zn Content z. The samples were sintered at 900 °C with addition of 3 wt% Bi2O3 as sintering aid and densities of above 92% were achieved. The room temperature resistivity and thermistor B-constants are almost independent of composition at 0 ≤ z ≤ 0.6 and start to increase at higher Zn concentrations. A multilayer NTC thermistor was fabricated using green tapes of a spinel of composition z = 0.75, commercial Ag paste, and cofiring at 900 °C. The firing behavior, microstructure formation and electrical properties of the multilayer thermistor are reported.
NMR refinement and peptide folding using the GROMACS software
Authors: Sinelnikova Anna , Spoel David van der 
Published: March 2021

AbstractNuclear magnetic resonance spectroscopy is used routinely for studying the three-dimensional structures and dynamics of proteins and nucleic acids. Structure determination is usually done by adding restraints based upon NMR data to a classical energy function and performing restrained molecular simulations. Here we report on the implementation of a script to extract NMR restraints from a NMR-STAR file and export it to the GROMACS software. With this package it is possible to model distance restraints, dihedral restraints and orientation restraints. The output from the script is validated by performing simulations with and without restraints, including the ab initio refinement of one peptide.
Semi-Lagrangian Subgrid Reconstruction for Advection-Dominant Multiscale Problems with Rough Data
Authors: Simon Konrad , Behrens Jörn 
Published: March 2021

AbstractWe introduce a new framework of numerical multiscale methods for advection-dominated problems motivated by climate sciences. Current numerical multiscale methods (MsFEM) work well on stationary elliptic problems but have difficulties when the model involves dominant lower order terms. Our idea to overcome the associated difficulties is a semi-Lagrangian based reconstruction of subgrid variability into a multiscale basis by solving many local inverse problems. Globally the method looks like a Eulerian method with multiscale stabilized basis. We show example runs in one and two dimensions and a comparison to standard methods to support our ideas and discuss possible extensions to other types of Galerkin methods, higher dimensions and nonlinear problems.
Superior outcomes with Argatroban for heparin-induced thrombocytopenia: a Bayesian network meta-analysis
Authors: Colarossi Giorgia , Maffulli Nicola , Trivellas Andromahi , Schnöring Heike , Hatam Nima , Tingart Markus , Migliorini Filippo 
Published: March 2021

AbstractBackground Argatroban, lepirudin, desirudin, bivalirudin, and danaparoid are commonly used to manage heparin-induced thrombocytopenia related complications. However, the most suitable drug for this condition still remains controversial. Aim of the review This Bayesian network meta-analysis study compared the most common anticoagulant drugs used in the management of heparin-induced thrombocytopenia. Method All clinical trials comparing two or more anticoagulant therapies for suspected or confirmed heparin-induced thrombocytopenia were considered for inclusion. Studies concerning the use of heparins or oral anticoagulants were not considered. Data concerning hospitalisation length, thromboembolic, major, and minor haemorrhagic events, and mortality rate were collected. The network analyses were made through the STATA routine for Bayesian hierarchical random-effects model analysis with standardised mean difference (SMD) and log odd ratio (LOR) effect measures. Results Data from a total of 4338 patients were analysed. The overall mean age was 62.31 ± 6.6 years old. Hospitalization length was considerably shorter in favour of the argatroban group (SMD: − 1.70). Argatroban evidenced the lowest rate of major (LOR: − 1.51) and minor (LOR: − 0.57) haemorrhagic events. Argatroban demonstrated the lowest rate of thromboembolic events (LOR: 0.62), and mortality rate (LOR: − 1.16). Conclusion Argatroban performed better overall for selected patients with HIT. Argatroban demonstrated the shortest hospitalization, and lowest rate of haemorrhages, thromboembolisms, and mortality compared to bivalirudin, lepirudin, desirudin, and danaparoid.
The Tyranny of ‘Teaching and Learning’
Authors: Buckley Alex 
Published: March 2021

AbstractThe phrase ‘teaching and learning’ has essentially replaced the word ‘teaching’ in educational discourse. The linguistic shift occurred as part of a wider movement in the 1980s and 1990s to give greater attention to learning in the educational process, and the phrase served a sloganistic function. With the learning paradigm now largely uncontroversial, the phrase—like other ex-slogans—may now be carrying implications more tied to its literal meaning. This paper suggests that the constant reference to learning in the context of teaching carries the implication that teaching is always accompanied by learning. After applying Gilbert Ryle’s distinction between task and achievement verbs, the paper argues that under certain interpretations, the idea that teaching implies learning is deeply problematic. The paper proposes that we instead use ‘teaching and studying’: to communicate the deep connections between the activities carried out by teachers and students, without supporting the unhelpful idea that the activity of teaching must always lead to the achievement of learning.
The Double Intentionality of Moral Intentional Actions: Scotus and Ockham on Interior and Exterior Acts
Authors: Schierbaum Sonja 
Published: March 2021

AbstractAny account of intentional action has to deal with the problem of how such actions are individuated. Medieval accounts, however, crucially differ from contemporary ones in at least three respects: (i) for medieval authors, individuation is not a matter of description, as it is according to contemporary, ‘Anscombian’ views; rather, it is a metaphysical matter. (ii) Medieval authors discuss intentional action on the basis of faculty psychology, whereas contemporary accounts are not committed to this kind of psychology. Connected to the use of faculty psychology is (iii) the distinction between interior and exterior acts. Roughly, interior acts are mental as opposed to physical acts, whereas exterior acts are acts of physical powers, such as of moving one’s body. Of course, contemporary accounts are not committed to this distinction between two ontologically different kinds of acts. Rather, they might be committed to views consistent with physicalist approaches to the mind. The main interpretative task in this paper is to clarify how Scotus and Ockham explain moral intentional action in terms of the role and involvement of these kinds of acts respectively. I argue that Scotus’s account is close to contemporary, ‘Anscombian’ accounts, whereas Ockham’s account is incompatible with them.
Financial losses for Dutch stakeholders during the 2013 aflatoxin incident in Maize in Europe
Authors: Focker M. , van der Fels-Klerx H. J. , Oude Lansink A. G. J. M. 
Published: March 2021

AbstractEarly 2013, high concentrations of aflatoxin M1 were found in the bulk milk of a few dairy farms in the Netherlands. These high concentrations were caused by aflatoxin B1 contaminated maize from Eastern Europe that was processed into compound feed, which was fed to dairy cows. Since the contamination was discovered in the downstream stages of the supply chain, multiple countries and parties were involved and recalls of the feed were necessary, resulting into financial losses. The aim of this study was to estimate the direct short-term financial losses related to the 2013 aflatoxin incident for the maize traders, the feed industry, and the dairy sector in the Netherlands. First, the sequence of events of the incident was retrieved. Then, a Monte Carlo simulation model was built to combine the scarce and uncertain data to estimate the direct financial losses for each stakeholder. The estimated total direct financial losses of this incident were estimated to be between 12 and 25 million euros. The largest share, about 60%, of the total losses was endured by the maize traders. About 39% of the total losses were for the feed industry, and less than 1% of the total losses were for the dairy sector. The financial losses estimated in this study should be interpreted cautiously due to limitations associated with the quality of the data used. Furthermore, this incident led to indirect long-term financial effects, identified but not estimated in this study.
Coulomb stress analysis for several filling and operational scenarios at the Grand Ethiopian Renaissance Dam impoundment
Authors: Madson Austin , Sheng Yongwei 
Published: March 2021

AbstractIncreased demand for power generation coupled with changing seasonal water uncertainty has caused a worldwide increase in the construction of large hydrologic engineering structures. That said, the soon-to-be-completed Grand Ethiopian Renaissance Dam (GERD) will impound the Blue Nile River in Western Ethiopia and its reservoir will encompass ~ 1763 km2 and store ~ 67 Gt (km3) of surface water. The impoundment will undergo maximum seasonal load changes of ~ 28 to ~ 36 Gt during projected seasonal hydroelectric operations. The GERD impoundment will cause significant subsurficial stresses, and could possibly trigger seismicity in the region. This study examines Coulomb stress and hydrologic load centroid movements for several GERD impoundment and operational scenarios. The maximum subsurficial Coulomb stress applied on optimally oriented fault planes from the full impoundment is ~ 186 kPa and over 30% of our model domain incurs Coulomb stresses ≥ 10 kPa, regardless of the impoundment period length. The main driver behind Coulomb stress and load centroid motion during impoundment is the annual, accumulated daily reservoir storage change. The maximum Coulomb stresses from the highest amplitude season of five long-term operational scenarios are around 36, 33, 29, 41, and 24% of the total maximum stresses from the entire GERD impoundment. Variations in annual Coulomb stresses during modeled GERD operations are attributed to the seasonal load per unit area, and partially to the initial seasonal water level. The spatial patterns and amplitudes of these stress tensors are closely linked to both the size and timing of GERD inflow/outflow rates, and an improved understanding of the magnitude and extent of these stresses provides useful information to water managers to better understand potential reservoir triggered seismic events from several different operational and impoundment strategies.
Simple Baseline Machine Learning Text Classifiers for Small Datasets
Authors: Riekert Martin , Riekert Matthias , Klein Achim 
Published: March 2021

AbstractText classification is important to better understand online media. A major problem for creating accurate text classifiers using machine learning is small training sets due to the cost of annotating them. On this basis, we investigated how SVM and NBSVM text classifiers should be designed to achieve high accuracy and how the training sets should be sized to efficiently use annotation labor. We used a four-way repeated-measures full-factorial design of 32 design factor combinations. For each design factor combination 22 training set sizes were examined. These training sets were subsets of seven public text datasets. We study the statistical variance of accuracy estimates by randomly drawing new training sets, resulting in accuracy estimates for 98,560 different experimental runs. Our major contribution is a set of empirically evaluated guidelines for creating online media text classifiers using small training sets. We recommend uni- and bi-gram features as text representation, btc term weighting and a linear-kernel NBSVM. Our results suggest that high classification accuracy can be achieved using a manually annotated dataset of only 300 examples.