bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of cathepsins in Alzheimer's disease: A systematic review
Authors: Rastegar S. , Nouri A. , Masoudi R. , Tavakoli R. 
Published: May 2021

Alzheimer's disease (AD) is a multifactorial disease. In addition to the precipitating of two proteins betaamyloid peptide and neurofebrillary tangles, which are the main mechanisms involved in the pathogenesis ofAD, other factors such as inflammatory mechanisms and changes in lysosomal enzymes play an important part in the pathogenesis of this disease. Increased and decreased lysosomal proteases, such as cathepsin, can lead to functional impairment and gradual death of neurons. The aim of this review was to investigate the role of cathepsins in the pathogenesis of AD. To conduct this review, relevant articles published between 2000 and 2016, and indexed in reliable databases including PubMed, Google Scholar, Scopus and Web of Science were retrieved. After reviewing the articles, 30 articles that directly addressed the subject of this review were included in final analysis. Cathepsins exacerbate intracellular conditions in neurons, by processing beta-amyloid precursor protein and converting it into amyloid beta. They also play a protective role against AD and fight it by catalyzing the decomposition of beta-amyloids and converting them into the cut out forms of the carboxyl C-terminus. In addition, the 24 kDa fragment resulting from the effect of cathepsin D on apolipoprotein E (ApoE) is the second binding to the receptor in the ApoE. This fragment may also be the cause of the pathogenicity of Apo E in AD. Identifying and explaining the mechanisms involved in the pathogenesis of AD can play a significant role in the prevention and treatment of this disease. Since cathepsins play a pivotal role in the decomposition of beta-amyloid and reduction of the risk of AD, further studies can be considered an effective approach to study AD.Journal of Medical and Biomedical Sciences (2018) 7(1), 1 - 10
Restructuring and Automation of Security Model for Sustainable Development in Nigeria
Authors: Okedion Mike Akhaze 
Published: May 2021

Nigeria has on daily basis experienced an upsurge of activities that threatens and endangers its national security. In recent times, the Nigerian nation suddenly metamorphosed into an abode of insecurity. Security is presently a major challenge in Nigeria especially in Northern Nigeria. Nigerians and non-Nigerians are killed on daily basis and in their numbers even the United Nations building and the Police Headquarters at the Federal Capital were bombed. Though the government claims to be on top of the situation, the problem persists. Despite its abundant oil wealth, there has been unimaginable level of lack of infrastructure, automated security amenities and negligible development generally. One of the major setbacks to development in Nigeria is insecurity. Until very recently, plethora of explanations on the crawling pace of development in Nigeria tends to pay infinitesimal attention to the centrality of security to national development. It is no surprise therefore that since 1999 when Nigeria returned to civil rule insecurity tends to have hampered national development. Security is evidently the pillar upon which every meaningful development could be achieved and sustained. In view of this scenario, the paper basically analyses and recommends ways of ascertaining the impact of automated and improved security model for sustainable development in Nigeria. It therefore concludes and recommends amongst others, the formulation and effective implementation of policies capable of addressing the root causes of insecurity in Nigeria.
Keywords: Restructuring, Automation, Security Model, Development.
Youth Empowerment, Wealth Creation and Security as Key to National Development
Authors: Egwu Grace Ifeoma 
Published: May 2021

This paper examined youth empowerment, wealth creation and security as key to national development. The paper was guided by three objectives viz-a-viz; finding out how the empowerment of youth enhances national development, determining how wealth creation in the country is capable of enhancing national development and examining the role security play in entrenching national development. Reviews of literature were carried out in line with the objectives of the study using secondary data as method of data collection. The paper concluded that youth empowerment, wealth creation and national security enhance a nation’s positive and sustainable development. The paper suggested that government should make youth empowerment and wealth creation process in the country seamless so that majority of her unemployed youth can key into the scheme to uplift self and enhance national development. Also, the government should make national security a priority at all times. This is because without adequate security in the country, the zeal to be creative will be discouraged, investment will be limited, thus making development of the country to be stagnated as interested persons and organizations will be scared to invest.
Keywords: Youth Empowerment, Wealth Creation, Security, National Development
Persepsi Masyarakat Mengenai Wabah Pandemi Covid-19 (Studi Fenomenologi Pada Desa Kayuloe Barat Kecematan Turatea Kabupaten Jeneponto )
Authors: Nasriadi Nasriadi , Asmi Nur 
Published: May 2021

Penelitian ini bertujuan untuk mengetahui persepsi masyarakat mengenai wabah pandemi covid 19 pada desa kayu loe barat. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah dengan observasi, wawancara, dan juga dokumentasi. Sumber data yang diolah merupakan sumber data primer dan data sekunder. Dan metode penelitian yang digunakan dalam penelitian ini adalah Kualitatif. Hasil penelitian dalam penelitian ini adalah persepsi masyarakat mengenai wabah pandemi covid 19 pada Desa Kayuloe Barat Kecematan Turatea Kabupaten Jeneponto adalah masyarakat sudah paham tentang adanya pandemi virus corona atau covid 19 serta bahaya yang ditimbulkan yang sedang mewabah pada saat ini, dan paham cara pencegahan agar terhindar dari virus corona atau covid 19, yaitu dengan mengikuti protokol kesehatan yang telah diterapkan oleh pemerintah, dan dengan adanya pandemi covid 19 di masyarakat menyebabkan beberapa dampak seperti dampak ekonomi dan dampak sosial sehingga masyarakat semakin sulit karena dampak yang di timbulkan oleh pandemi covid 19 ini.
IDENTIFIKASI KEARIFAN LOKAL SEBAGAI UPAYA UNTUK MENINGKATKAN DAYA TARIK WISATA GREEN VILLAGE GEDANGSARI DI KABUPATEN GUNUNGKIDUL
Authors: Sugiarto Eko , Haryanti Dian 
Published: May 2021

This study aims to identify local wisdom in Green Village Gedangsari, Gunungkidul Regency. This research uses qualitative method with combined data collection technique, there are observation, interview, and documentation. Some invention that have been identified as the findings of this research are (1) Tourism development in Green Village Gedangsari; (2) Some of the taboos that local people believe; (3) Local culinary; (4) The place of the sacred; (5) Nyadran and Rosulan Traditions; and (6) 4G development plan by Gedangsari community. These findings have the potential to increase tourist attraction in the Green Village Gedangsari region.
Keywords: Local Wisdom, Tourist Attractions
GAYA HIDUP MINUM KOPI DALAM PENGAMBILAN KEPUTUSAN PEMBELIAN KOPI (STUDI KASUS PADA KOPI KENANGAN GANDARIA CITY - JAKARTA)
Authors: Selvi Selvi , Ningrum Lestari 
Published: May 2021

Coffee is a drink that is preferred among the people. Coffee is a type of beverage that comes from the processing and extraction of coffee beans. Coffee comes from Arabic qahwah which means strength. Coffee can be said as a drink that provides energy. At this time there was a booming coffee shop business. These days the emergence of various types of coffee shops that sell various types of coffee drinks are supported by the interior and various unique concepts that can not be separated from people’s lives. This has led to consumptive behavior that mainly occurs among young people so they are happy to be in a coffee shop. This study aims to explain and find out whether there is an influence of lifestyle on a person’s purchasing decisions in the Coffee Memories of Gandaria City, especially among young people. The independent variables used in this study are Activity, Interest and Opinion. Sample population used in this study are visitors or consumers who are or have made purchases of Kengangan Gandaria City Coffee as many as 100 people. This research uses descriptive method. Based on the results of the determination test shows the number of 0.700 so it can be concluded that purchasing decisions are significantly influenced by lifestyle. This shows that the occurrence of consumptive lifestyles that affect a person in making purchase decisions. Lifestyle variables on opinion indicators provide the most powerful influence compared to other indicators.
Keywords: lifestyle, buyer decision, coffe shop, food and beverage product
NEW NORMAL PARIWISATA YOGYAKARTA
Authors: Wicaksono Ajie 
Published: May 2021

The Covid-19 pandemic has a major impact on the tourism sector in DIY which causes material losses to Regional Original Income (PAD). This study aims to describe changes in the tourism sector in the conditions before the pandemic, during the pandemic, and the new normal. The results showed that the tourism sector during the pandemic and the new normal era must implement (1) health protocols for the tourism industry such as hotels, restaurants, tourist destinations, and transportation for both visitors and employees by paying attention to cleanliness, health and safety (cleanliness, health, and safety) by providing hygiene facilities such as hand washing and soap, hand sanitizers, and temperature checks with a thermo gun. The hotel even provides isolation rooms for visitors with corona symptoms, (2) Payment using electronic money (cashless). (3) Limiting the number of visitors to prevent crowds and provide a safe distance to minimize spread, and (4) Tourist locations are opened gradually by prioritizing low-risk areas such as natural and mountainous areas.
Keywords: Tourism, Covid-19, New Normal, Health Protocol
PEMANFAATAN MUSEUM SEBAGAI OBJEK WISATA EDUKASI
Authors: Prasetyo Danang , Manik Toba Sastrawan , Riyanti Dwi 
Published: May 2021

The purpose of this study is to describe or strengthen the function of the museum as a means of education outside the classroom as part of the co-curricular education program. This program is often referred to as an educational tourism activity. This research is a descriptive qualitative research that uses data collection methods through literature study using various sources such as books, journal articles, and news sources that support the research. Data collection, data processing, and data analysis were carried out from September 2020 to January 2021. The conclusions of this study are: (1) museums have an educational function that must be elaborated and used as a source, media, and place of learning as part of educational co-curricular program. Museums provide open communication about ideas, concepts, information involving exploration and discovery. Museum is a place of learning for 3A (the authentic, the aesthetic, and the accessible). (2) it is necessary to increase the role, quality and professionalism of the teaching staff so that the museum can function effectively and improve the quality of education. (3) it is necessary to have the role of museum managers and related policy makers to optimize the quality and accessibility so that the museum is easily accessible to tourists and is open to educational programs. In addition, innovation is needed in managing museum tourism so that it can attract tourists. Thus, synergy is needed between museum managers as providers and formal educational institutions as users in the use of museums in educational functions.
Keywords: Museums, Object Tourism, Education Tourism
DAYA SAING TEKNOLOGI DESTINASI PARIWISATA DKI JAKARTA BERDASARKAN PERSEPSI WISATAWAN
Authors: Nurbaeti Nurbaeti , Damanik Janianton , Baiquni Muhammad , Nopirin Nopirin 
Published: May 2021

This study aims to examine and analyze the use of technology in improving the competitiveness of the tourism destination based on tourists’ perception, and also to see the difference level of technology competitiveness. This research has been conducted specifically to analyse the technology competitiveness at the three main tourist destinations mentioned above based on the visitors’s perception, and why the perception could be different. This study is a survey research which explains social phenomena and causal relationship among the variables of socio-economic characteristics (group of origin, level of education, and and income level) towards the competitiveness of technology parameter in the three tourist destination through hypothesis testing. Information was collected from 300 respondents using the questionnaire, and for each tourist destination, for the-100 respondent, the unit analyzed are individuals (tourists). Sample are tourists to the three main destinations in Jakarta during May, August, and September 2014. The selected samples are those who have visited the three different tourist destination within the last three years whose age are 15 years or more. The collected data were then analyzed using Kruskall-Walls statistical test, i.e. nonparametric analysis instrument to see whether there are any difference between two conditions. Based on group of origin, level of education, and income level of the respondents, the results showed have no differences in perception to technology competitiveness of the three tourist destinations.
Keywords: tourist destination, tourists’ perception, tourism destination competitiveness
A PERCEPÇÃO DO PROFISSIONAL DE SAÚDE DIANTE DO ÓBITO INFANTIL
Authors: Guedes Jennyfer Katheryne , Guedes Sthefanny , Follador Franciele Ani Caovilla , Vieira Ana Paula , Pereira Alaba Cristina , Yamada Roberto Shigueyasu , Ferreto Lirane Elize Defante 
Published: May 2021

A presente investigação teve como objetivo analisar a perspectiva, reações e sentimentos dos profissionais de saúde a respeito dos óbitos infantis. Pesquisa qualitativa e descritiva desenvolvida na área de abrangência da 8ª. Regional de Saúde de Francisco Beltrão junto aos profissionais de saúde na área de cobertura de mães que tiveram perda infantil. Cinco profissionais, que em algum momento tiveram contato com o infante que foi a óbito, foram entrevistados através de um questionário semiestruturado norteado por pontos que abordavam a concepção em relação à morte. Identificou-se na análise três categorias: 1) percepção da morte e do morrer; 2) da formação acadêmica à prática profissional e 3) evocações e crenças. Conclui-se que existe a necessidade de implantação de política que preparem os profissionais da saúde para lidar com a morte e o morrer a fim de que a arte de lidar com seres humanos seja menos penoso, triste e estressante.
PENERAPAN PRINSIP BUSINESS JUDGMENT RULE TERHADAP DIREKSI YANG MELAKUKAN KEBIJAKAN YANG MERUGIKAN PERUSAHAAN
Authors: Panjaitan Robin , Anggusti Martono , Nababan Roida 
Published: May 2021

Penelitian ini ditujukan untuk memahami penerapan business judgement rule pada direksi yang menjalankan fungsi pengurusan Perseroan dan Perlindungan Hukum terhadap direksi dalam pengurusan perusahaan melakukan kebijakan yang merugikan perusahaan dikaitkan pada Undang-Undang No. 40 Tahun 2007 tentang Perseroan Terbatas. Penelitian ini merupakan penelitian yuridis normatif dengan metode pendekatan penelitian terhadap pendekatan perundang-undangan. Sumber data berdasarkan data primer, sekunder dan tersier yang dianalisis secara yuridis deskriftif. Hasil penelitian menunjukkan bahwa penerapan Business Judgement Rule memberikan perlindungan hukum bagi direksi dan pejabat perseroan dari pertanggungjawaban atas setiap kebijakan atau keputusan bisnis atau transaksi yang mengakibatkan kerugian bagi perseroan, selama kebijakan atau keputusan bisnis atau transaksi tersebut dilakukan dengan itikad baik, penuh kehati-hatian, serta dalam lingkup tanggung jawab dan wewenangnya
TransEBM v. 1.0: description, tuning, and validation of a transient model of the Earth's energy balance in two dimensions
Authors: Ziegler Elisa , Rehfeld Kira 
Published: May 2021

Abstract. Modeling the long-term transient evolution of climate remains a technical and scientific challenge.
However, understanding and improving modeling of the long-term behavior of the climate system increases confidence in projected changes in the mid- to long-term future.
Energy balance models (EBMs) provide simplified and computationally efficient descriptions of long timescales and allow large ensemble runs by parameterizing energy fluxes. In this way, they can be used to pinpoint periods and phenomena of interest.
Here, we present TransEBM, an extended version of the two-dimensional energy balance model by Zhuang et al. (2017a). Transient CO2, solar insolation, orbital configuration, fixed ice coverage, and land–sea distribution are implemented as effective radiative forcings at the land surface.
We show that the model is most sensitive to changes in CO2 and ice distribution, but the obliquity and land–sea mask have significant influence on modeled temperatures as well.
We tune TransEBM to reproduce the 1960–1989 CE global mean temperature and the Equator-to-pole and seasonal temperature gradients of ERA-20CM reanalysis (Hersbach et al., 2015).
The resulting latitudinal and seasonal temperature distributions agree well with reanalysis and the general circulation model (GCM) HadCM3 for a simulation of the past millennium (Bühler et al., 2020).
TransEBM does not represent the internal variability of the ocean–atmosphere system, but non-deterministic elements and nonlinearity can be introduced through model restarts and randomized forcing.
As the model facilitates long transient simulations, we envisage its use in exploratory studies of stochastic forcing and perturbed parameterizations, thus complementing studies with comprehensive GCMs.
Integrated mapping of water-related disasters using the analytical hierarchy process under land use change and climate change issues in Laos
Authors: Phakonkham Sengphrachanh , Kazama So , Komori Daisuke 
Published: May 2021

Abstract. In the past few decades, various natural hazards have occurred in Laos. To
lower the consequences and losses caused by hazardous events, it is
important to understand the magnitude of each hazard and the potential
impact area. The main objective of this study was to propose a new approach
to integrating hazard maps to detect hazardous areas on a national scale,
for which area-limited data are available. The integrated hazard maps were
based on a merging of five hazard maps: floods, land use changes,
landslides, climate change impacts on floods, and climate change impacts on
landslides. The integrated hazard map consists of six maps under three representative concentration pathway (RCP) scenarios and two time periods
(near future and far future). The analytical hierarchy process (AHP) was
used as a tool to combine the different hazard maps into an integrated
hazard map. From the results, comparing the increase in the very high hazard area between the integrated hazard maps of the far future under the RCP2.6 and RCP4.5 scenarios, Khammouan Province has the highest increase (16.45 %). Additionally, the very high hazard area in Khammouan Province increased by approximately 12.47 % between the integrated hazard maps under the RCP4.5 and RCP8.5 scenarios of the far future. The integrated hazard maps can pinpoint the dangerous area through the whole country, and the map can be used as primary data for selected future development areas. There are some limitations of the AHP methodology, which supposes linear
independence of alternatives and criteria.
Mehr literarischer Entdecker als Polarheld: Arthur Conan Doyles Reise in die Arktis (1880)
Authors: Göllnitz Martin 
Published: May 2021

Abstract. Hört man den Namen Arthur Conan Doyle, so denkt man natürlich
zunächst an seinen literarischen Helden und Meisterdetektiv Sherlock
Holmes, weniger an den Schriftsteller selbst. Doch nicht nur Londons
Verbrechensbekämpfer Nr. 1 und sein getreuer Kompagnon Dr. John Watson
haben zahlreiche Abenteuer erlebt und Gefahren getrotzt, auch deren Erfinder
kann auf ein aufregendes und mitunter lebensgefährliches Unternehmen
zurückblicken – das überdies vielfältige Inspirationen für
dessen literarisches Schaffen bereithielt. Der vorliegende Artikel nimmt
dieses Abenteuer, das Doyle im Alter von 20 Jahren als Mitglied und
Schiffsarzt auf einem englischen Walfänger erlebte, in den Blick und
fragt danach, wie der noch junge Medizinstudent die Arktis als Natur- und
Gefahrenraum wahrnahm, von ihr beeinflusst wurde und in einem ihm fremden,
sozialen Milieu agierte.
LITERATURE REVIEW: PENGARUH RESISTANCE EXERCISE DENGAN ELASTIC BAND UNTUK EKSTREMITAS BAWAH TERHADAP WALKING SPEED PADA LANJUT USIA
Authors: Setiawan Annisa Indahtyas Mussalam , Wibisono Heri 
Published: May 2021

Tujuan dari penelitian ini adalah untuk mengetahui adakah pengaruh Resistance Exercise dengan Elastic Band untuk ekstremitas bawah terhadap walking speed pada lanjut usia, sehingga dapat me minimalisir resiko jatuh pada lanjut usia. Pasien lanjut usia dengan fisik yang sehat secara umum dan dapat berjalan tanpa bantuan. Penelitian ini menggunakan metore Studi Literatur. Dari penemuan 6 jurnal yang bersumber dari Google Schoolar, Pubmed, Scient Direct, dan Jospt bahwa Resistance Exercise menggunakan Elastic Band untuk ekstremitas bawah terhadap Walking Speed pada lanjut usia terdapat perubahan yang signifikan pada durasi berjalan, disisi lain dalam studi Saeterbakken et al., 2018 tidak ada perubahan yang signifikan pada durasi berjalan. Dari 6 studi, Test Kecepatan Berjalan menggunakan Resistance Exercise menggunakan intervensi (Elastic Band) dengan parameter berbeda, disimpulkan bahwa kecepatan berjalan menggunakan parameter 4,44 Meter Walk dan Fried Frailty Phenotype lebih baik digunakan dibandingkan dengan Minnesota Living with Heart Failure Questionnaire (MLHFQ) dan Time Up and Go Test (TUG). Kata Kunci : mobilitas fisik, bergerak, resiko jatuh, kelemahan otot
LITERATURE REVIEW : HUBUNGAN KOORDINASI TERHADAP KETERAMPILAN MENENDANG BOLA PADA PEMAIN SEPAK BOLA
Authors: Haryanti Eka Fitri , Agustiyawan Agustiyawan , Purnamadyawati Purnamadyawati , Hanidar Hanidar 
Published: May 2021

Menendang bola merupakan teknik dasar yang penting dalam permainan sepak bola yang salah satu tujuannya yaitu menembak bola ke gawang lawan (shooting). Kemampuan menendang bola yang baik, berkaitan dengan koordinasi, karena koordinasi berfungsi untuk mengarahkan bola secara tepat dan akurat saat melakukan tendangan. Tujuan literature review ini adalah untuk menganalisa serta menelaah penelitian yang telah dilakukan sebelumnya mengenai hubungan koordinasi terhadap keterampilan menendang bola pada pemain sepak bola. Metode yang digunakan pada literature review ini yaitu metode traditional literature review, yang merupakan analisis secara komprehensif, kritis, dan objektif terkait dengan ilmu atau pengetahuan mengenai topik tertentu yang tidak memiliki metode khusus dalam strategi pencarian pustaka. 5 dari 6 artikel yang direview oleh penulis menunjukkan hasil bahwa terdapat hubungan koordinasi terhadap keterampilan menendang bola pada pemain sepak bola. Hal ini disimpulkan berdasarkan hasil artikel yang telah direview oleh penulis dan berdasarkan penilaian kualitas artikel yang dinilai melalui Scimago Journal & Country Rank (SJR) yang memiliki nilai Q4, Sinta (Science and Technology Index) yang memiliki nilai S3 dan S4, dan critical appraisal yang mendapatkan hasil dengan nilai kategori A (high) dan B (limited) dalam levels of internal validity. Kata Kunci: koordinasi, menembak, menendang bola, sepak bola