bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute oxygen use in hospitalised patients with chronic obstructive pulmonary disease is guideline discordant
Authors: Deshpande Sheetal , Datey Nainika , Liacos Alexandra , Joosten Simon A. , Leong Paul 
Published: May 2021

AbstractAmple evidence supports an association between acute oxygen over‐administration and harm. Australian and international guidelines consistently recommend lower oxygen saturation aims in populations with chronic obstructive pulmonary disease (COPD). We assessed adherence to acute oxygen use guidelines and outcomes in hospitalised patients with COPD at a large Australian metropolitan hospital network.
Essentials of a new clinical practice guidance on familial hypercholesterolaemia for physicians
Authors: Watts Gerald F. , Sullivan David R. , Hare David L. , Kostner Karam M. , Horton Ari E. , Bell Damon A. , Brett Tom , Trent Ronald J. , Poplawski Nicola K. , Martin Andrew C. , Srinivasan Shubha , Justo Robert N. , Chow Clara K. , Pang Jing ,   and members of the FH Australasia Network Consensus Working Group
Published: May 2021

AbstractFamilial hypercholesterolaemia (FH) is a common, heritable and preventable cause of premature coronary artery disease. New clinical practice recommendations are presented to assist practitioners in enhancing the care of all patients with FH. Core recommendations are made on the detection, diagnosis, assessment and management of adults, children and adolescents with FH. Management is under‐pinned by the precepts of risk stratification, adherence to healthy lifestyles, treatment of non‐cholesterol risk factors and appropriate use of low‐density lipoprotein (LDL)‐cholesterol‐lowering therapies including statins, ezetimibe and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. The recommendations need to be utilised using judicious clinical judgement and shared decision‐making with patients and families. New government‐funded schemes for genetic testing and use of PCSK9 inhibitors, as well as the National Health Genomics Policy Framework, will enable adoption of the recommendations. However, a comprehensive implementation science and practice strategy is required to ensure that the guidance translates into benefit for all families with FH.
Lockdown impact on lifestyle and its association with oral parafunctional habits and bruxism in a Spanish adolescent population
Authors: Carrillo‐Diaz María , Ortega‐Martínez Ana Raquel , Romero‐Maroto Martín , González‐Olmo María José 
Published: May 2021

AbstractAimTo analyse the possible association between decreased physical and social activity and an increase in the use of mobile devices, internet, and social networks with increased anxiety and the appearance of oral parafunctions and bruxism for adolescents before and during COVID‐19.DesignA total of 213 adolescents attended private clinics at two different times: before lockdown (T0) and after completion of total lockdown (T1). In T0 and T1, a clinical examination was carried out to assess dental wear (IA) and only in T1 were they given the self‐report questionnaire which focuses on the periods before and during lockdown (self‐reported bruxism, state anxiety, mobile phone and internet, social network use, physical and social activity, and questions on parafunctions).ResultsThere were a decrease in physical activity at T0‐T1 and an increase in social media use, internet, state anxiety, and clinical and self‐reported bruxism at T0‐T1. There was a positive correlation between increased self‐reported bruxism, increased social media use, mobile device use, and state anxiety.ConclusionsThere has been a change in adolescent lifestyle during lockdown with an increase in the prevalence of oral parafunctions and bruxism. In particular, the increase in the use of social networks at night and also in anxiety levels during lockdown were associated with of the increase in self‐reported bruxism.
Substantial gene flow caused by long‐term translocation between natural bank populations of the Peruvian scallop (Argopecten purpuratus) is supported by RAD‐Seq analyses
Authors: Velez‐Zuazo Ximena , Barahona Sergio P. , Melo Omar G. , Hanschke Eric , Hanschke Ian , Santa‐Maria Monica C. 
Published: May 2021

AbstractThe Peruvian scallop (Argopecten purpuratus, Lamarck 1989) is a marine bivalve of high commercial value in the aquaculture industry, with wild populations distributing from northern Peru to Chile. Growing demand for it in the world aquaculture markets and limited availability of hatchery‐based seeds caused long‐term seed translocations among wild populations to recover depleted local populations and for production needs. We investigated long‐term translocation effects on the genetic diversity and structure of wild populations using next‐generation RAD sequencing. We sampled individuals from Sechura, Lobos de Tierra, Samanco, and Bahia Independencia in Peru, and La Rinconada in Northern Chile. We identified 8,345 polymorphic RAD loci and 24,218 SNPs for the five populations. We estimated high observed heterozygosity for all populations and high SNP frequency compared to similar studies on marine bivalves. We detected no spatial divergence among populations in Peru (pairwise FST from 0 to 0.003), but strong differentiation with the population in Chile. Migration rate estimates suggested asymmetric directionality of seed translocation. Overall, our results support a remnant effect of an intense historic translocation and ongoing gene flow among wild populations in Peru, challenging the identification of outlier loci and certification of sustainable origin of cultured scallops using genetic markers.
Scars of Conflict in the Population Structure of Iraqi Kurdistan: An Unfortunate Cohort and Its “Fortunate” Survivors
Authors: Zeyneloglu Sinan , Aymerich Olga , Mzuri Gohdar , Sirkeci Ibrahim 
Published: May 2021

AbstractUsing the 2017 Demographic Survey of the Kurdistan Region of Iraq, older Iraqi censuses, the 2016 Census of Iran, and reports on displacement in Iraq, we expose the male deficit in the 1958–1962 birth cohort of Iraqi Kurdistan over time, probe its origins, and illustrate its effects on the rest of the population while relating these to the historical context of the exodus of the Kurdish resistance in Iraq to Iran in 1975. In addition to heightened mortality, a number of families appear to have sent some of their teenage sons to Iran to avoid their involvement in the conflict as fighters, victims, or both. Their absence has enabled the remaining males of the 1958–1962 cohort to enjoy an advantageous position in the marriage and labor markets, while their corresponding mating partners, the females of the 1963–1967 cohort, were the first generation of Iraqi Kurdish females to pursue education and employment en masse. Illustrating the effect of conflict over demographic structure, we highlight the need for further research into two interrelated aspects: the strategies of mothers to keep their male offspring safe via selective out‐migration during conflict, and the resulting emancipation of females due to postconflict male shortage.
Transient hypoxia in water irradiated by swift carbon ions at ultra-high dose rates: implication for FLASH carbon-ion therapy
Authors: Zakaria Abdullah Muhammad , Colangelo Nicholas W. , Meesungnoen Jintana , Jay-Gerin Jean-Paul 
Published: May 2021

Large doses of ionizing radiation delivered to tumors at ultra-high dose rates (i.e., in a few milliseconds) paradoxically spare the surrounding healthy tissue while preserving anti-tumor activity (compared with conventional radiotherapy delivered at much lower dose rates). This new modality is known as “FLASH radiotherapy” (FLASH-RT). Although the molecular mechanisms underlying FLASH-RT are not yet fully understood, it has been suggested that radiation delivered at high dose rates spares normal tissue via oxygen depletion followed by subsequent radioresistance of the irradiated tissue. To date, FLASH-RT has been studied using electrons, photons, and protons in various basic biological experiments, pre-clinical studies, and recently in a human patient. However, the efficacy of heavy ions, such as energetic carbon ions, under FLASH-RT conditions remains unclear. Given that living cells and tissues consist mainly of water, we set out to study, from a pure radiation chemistry perspective, the effects of ultra-high dose rates on the transient yields and concentrations of radiolytic species formed in water irradiated by 300-MeV per nucleon carbon ions (LET ∼ 11.6 keV/µm). This mimics irradiation in the “plateau” region of the depth–dose distribution of ions, i.e., in the “normal” tissue region in which the LET is rather low. We used Monte Carlo simulations of multiple, simultaneously interacting radiation tracks together with an “instantaneous pulse” irradiation model. Our calculations show a pronounced oxygen depletion around 0.2 μs, strongly suggesting, as with electrons, photons, and protons, that irradiation with energetic carbon ions at ultra-high dose rates is suitable for FLASH-RT.
A camera trap record of Asiatic Golden Cat Catopuma temminckii (Vigors & Horsfield, 1827) (Mammalia: Carnivora: Felidae) in State Land Forest, Merapoh, Pahang, Malaysia
Authors: Ismail Lukman , Sulaiman Syafiq , Nafi Muhammad Izzat Hakimi Mat , Nor Muhammad Syafiq Mohmad , Saimeh Nur Izyan Fathiah , Mohamad Nabihah , Bakar Ainur Izzati , Adanan Nurul Izzati , Shubli Nor Azmin Huda Mahamad , Razak Muhamad Hamirul Shah Ab , Sow Ai Yin , Karim Muhammad Firdaus Abdul , Abas Muhamad Azahar , Hassin Nor Hizami , Fauzi Norashikin , Amir Aainaa , Hambali Kamarul 
Published: May 2021

The Asiatic Golden Cat Catopuma temminckii is poorly studied in Peninsular Malaysia. We deployed 12 camera traps to assess the wildlife diversity in the unprotected State Land Forest of Merapoh, Pahang State. During the period from August to October 2019, one Asiatic Golden Cat was photographed at a single camera trap station. This record outside the protected area network emphasizes the importance of wildlife corridors. This State Land Forest is located between Forest Reserve and Taman Negara National Park. Therefore, appropriate conservation measures must be taken in order to maintain this site as a wildlife corridor.
Measuring Behavioral Similarity of Cellular Automata
Authors: Turney Peter D. 
Published: May 2021

Abstract
Conway's Game of Life is the best-known cellular automaton. It is a classic model of emergence and self-organization, it is Turing-complete, and it can simulate a universal constructor. The Game of Life belongs to the set of semi-totalistic cellular automata, a family with 262,144 members. Many of these automata may deserve as much attention as the Game of Life, if not more. The challenge we address here is to provide a structure for organizing this large family, to make it easier to find interesting automata, and to understand the relations between automata. Packard and Wolfram (1985) divided the family into four classes, based on the observed behaviors of the rules. Eppstein (2010) proposed an alternative four-class system, based on the forms of the rules. Instead of a class-based organization, we propose a continuous high-dimensional vector space, where each automaton is represented by a point in the space. The distance between two automata in this space corresponds to the differences in their behavioral characteristics. Nearest neighbors in the space have similar behaviors. This space should make it easier for researchers to see the structure of the family of semi-totalistic rules and to find the hidden gems in the family.
Comparing the New World and the Old: Fray Juan Bautista and the Languages of the Spanish Monarchy
Authors: Wasserman-Soler Daniel I. 
Published: May 2021

Abstract
Born in New Spain, fray Juan Bautista Viseo (b. 1555) authored perhaps a dozen books in Nahuatl, Castilian, and Latin, making him one of the most prolific writers of the colonial period in Mexico. While many are lost, his available texts provide a valuable window into religious conversion efforts in the Spanish monarchy around 1600. This paper investigates his recommendations regarding how priests and members of religious orders ought to use indigenous languages. In the sixteenth-century Spanish territories, Church and Crown officials discussed language strategies on several fronts. This paper also compares Juan Bautista’s ideas about language use in Mexico to similar discussions elsewhere in the Spanish kingdoms. Existing scholarship has highlighted parallels in how the Spanish monarchy dealt with Native American and Islamic communities. However, an examination of Juan Bautista’s writing, together with that of contemporary churchmen, suggests fundamental differences in the ways that Spanish officials thought about and approached Amerindians and Moriscos.
The International Court of Justice and the Responsibility to Protect: Learning from the Case of The Gambia v. Myanmar
Authors: Mennecke Martin 
Published: May 2021

Abstract
It is a commonplace in the R2P discourse to describe accountability measures as key means to implement the responsibility to protect. In particular, the International Criminal Court is regularly highlighted as a central actor, both in the literature, the annual R2P reports issued by the UN Secretary-General, and the subsequent debates in the UN General Assembly. Conspicuously absent from this conversation is the principal judicial organ of the United Nations, the International Court of Justice (icj). This article examines the potential role of the ‘World Court’, as The Gambia in November 2019 started a new case under the UN Genocide Convention against Myanmar before the icj. Analysing the limitations and prospects and existing icj case-law, the article concludes that the International Court of Justice can make an important and unique contribution to the responsibility to protect.
From China’s “Political Meritocracy” to “Just Hierarchy”
Authors: Mushkat Roda 
Published: May 2021

Abstract
Students of comparative constitutional design grapple with myriad complex normative and empirical issues. Prominent among them is the relative effectiveness of different governance regimes. Concerns stemming from the perceived malfunctioning of modern democracies have intensified efforts to diagnose and rectify the supposedly proliferating ills. The seemingly solid post-1978 Chinese record of steadily managing intricate societal challenges has highlighted the possible advantages of the country’s tightly controlled top-down institutional apparatus and its potential value as a model worth broadly exploring and even embracing on a meaningful scale. This view, authoritatively and vigorously articulated by an influential and prolific political philosopher and his academic associates, has evolved to a point whereby the Chinese constitutional order and contemporary experience are portrayed as being capable of fruitfully supplanting democratic structures or, alternatively, productively revitalising them. Yet, on the whole, this remains a controversial politico-legal proposition, conceptually problematic and lacking sufficient factual support.
Destratification and Restratification of the Spring Surface Boundary Layer in a Subtropical Front
Authors: Kunze Eric , Mickett John B. , Girton James B. 
Published: May 2021

AbstractDestratification and restratification of a ~50-m-thick surface boundary layer in the North Pacific Subtropical Front are examined during 24–31 March 2017 in the wake of a storm using a ~5-km array of 23 chi-augmented EM-APEX profiling floats (u, υ, T, S, χT), as well as towyo and ADCP ship surveys, shipboard air-sea surface fluxes, and parameterized shortwave penetrative radiation. During the first four days, nocturnal destabilizing buoyancy fluxes mixed the surface layer over almost its full depth every night followed by restratification to N ~ 2 × 10−3 rad s−1 during daylight. Starting on 28 March, nocturnal destabilizing buoyancy fluxes weakened because weakening winds reduced latent heat flux. Shallow mixing and stratified transition layers formed above ~20-m depth. A remnant layer in the lower part of the surface layer was insulated from destabilizing surface forcing. Penetrative radiation, turbulent buoyancy fluxes, and horizontal buoyancy advection all contribute to its restratification, closing the budget to within measurement uncertainties. Buoyancy advective restratification (slumping) plays a minor role. Before 28 March, measured advective restratification is confined to daytime; is often destratifying; and is much stronger than predictions of geostrophic adjustment, mixed-layer eddy instability, and Ekman buoyancy flux because of storm-forced inertial shear. Starting on 28 March, while small, the subinertial envelope of measured buoyancy advective restratification in the remnant layer proceeds as predicted by mixed-layer eddy parameterizations.
Efficacy of galcanezumab in patients with episodic cluster headaches and a history of preventive treatment failure
Authors: Plato Brian , Andrews J Scott , Rettiganti Mallikarjuna , Tockhorn-Heidenreich Antje , Bardos Jennifer , Wenzel Richard , Kuruppu Dulanji , Ambrosini Anna 
Published: May 2021

Objective: The efficacy of galcanezumab was evaluated in patients with episodic cluster headache and history of preventive treatment failure. Methods: In the randomized, 8-week, double-blind study (CGAL), patients with episodic cluster headache received once-monthly subcutaneous injections of galcanezumab 300 mg or placebo. Patients who completed CGAL and enrolled in an open-label study were queried for preventive treatment history. In a subset of patients with a known history of failure of verapamil or any other prior preventive treatment, a post hoc analysis of least square mean change from baseline in weekly cluster headache attack frequency across Weeks 1 to 3 was assessed. Results: Fifteen patients provided data for known history of prior preventive treatment failure (6 placebo, 9 galcanezumab), of whom 11 failed verapamil. The mean reduction in the weekly frequency of cluster headache attacks was greater with galcanezumab compared to placebo among patients with prior preventive treatment failure (8.2 versus 2.4); mean difference 5.8 (95% confidence interval [CI] 2.0, 13.6) and among patients with verapamil failure (10.1 versus 1.6); mean difference 8.5 (95% CI 0.4, 16.7). Conclusion: In this exploratory analysis of patients with a known history of prior preventive treatment failures, treatment with galcanezumab resulted in greater mean reductions in weekly cluster headache attacks compared with placebo. ClinicalTrials.gov: NCT02397473 (I5Q-MC-CGAL) NCT02797951 (I5Q-MC-CGAR)
Observation of the characteristics of the natural course of Bietti crystalline dystrophy by fundus fluorescein angiography
Authors: Zhang Shengjuan , Wang Lifei , Liu Zhiqiang , Sun Huijing , Li Qian , Xing Chen , Xiao Zhe , Peng Xiaoyan 
Published: May 2021

Abstract
Background
Bietti crystalline dystrophy (BCD) is an autosomal recessive genetic disorder that causes progressive vision loss. Here, 12 patients were followed up for 1–5 years with fundus fluorescein angiography (FFA) to observe BCD disease progression.

Methods
FFA images were collected for 12 patients with BCD who visited our clinic twice or more over a 5-year period. Peripheral venous blood was collected to identify the pathogenic gene related to the clinical phenotype.

Results
We observed two types in FFA images of patients with BCD. Type 1 showed retinal pigment epithelium (RPE) atrophy in the macular area, followed by choriocapillaris atrophy and the subsequent appearance of RPE atrophy appeared at the peripheral retina. Type 2 showed RPE atrophy at the posterior pole and peripheral retina, followed by choriocapillaris atrophy around the macula and along the superior and inferior vascular arcades and the nasal side of the optic disc. The posterior and peripheral lesions of both type 1 and type 2 BCD subsequently extended to the mid-periphery; finally, all the RPEs and choriocapillaris atrophied, exposing the choroid great vessels, but type 2 macular RPE atrophy could last longer.

Conclusions
The characterization of two different types of BCD development provides a better understanding of the phenotype and the progression of the disease for a precise prognosis and prediction of pathogenesis.
Identifying US County-level characteristics associated with high COVID-19 burden
Authors: Li Daniel , Gaynor Sheila M. , Quick Corbin , Chen Jarvis T. , Stephenson Briana J. K. , Coull Brent A. , Lin Xihong 
Published: May 2021

AbstractBackgroundIdentifying county-level characteristics associated with high coronavirus 2019 (COVID-19) burden can help allow for data-driven, equitable allocation of public health intervention resources and reduce burdens on health care systems.MethodsSynthesizing data from various government and nonprofit institutions for all 3142 United States (US) counties, we studied county-level characteristics that were associated with cumulative and weekly case and death rates through 12/21/2020. We used generalized linear mixed models to model cumulative and weekly (40 repeated measures per county) cases and deaths. Cumulative and weekly models included state fixed effects and county-specific random effects. Weekly models additionally allowed covariate effects to vary by season and included US Census region-specific B-splines to adjust for temporal trends.ResultsRural counties, counties with more minorities and white/non-white segregation, and counties with more people with no high school diploma and with medical comorbidities were associated with higher cumulative COVID-19 case and death rates. In the spring, urban counties and counties with more minorities and white/non-white segregation were associated with increased weekly case and death rates. In the fall, rural counties were associated with larger weekly case and death rates. In the spring, summer, and fall, counties with more residents with socioeconomic disadvantage and medical comorbidities were associated greater weekly case and death rates.ConclusionsThese county-level associations are based off complete data from the entire country, come from a single modeling framework that longitudinally analyzes the US COVID-19 pandemic at the county-level, and are applicable to guiding government resource allocation policies to different US counties.
Pyrvinium pamoate can overcome artemisinin’s resistance in anaplastic thyroid cancer
Authors: Li Yitian 
Published: May 2021

Abstract
Background
Anaplastic thyroid carcinoma is a highly lethal subtype of thyroid cancer without effective therapies. Drug resistance in anaplastic thyroid carcinoma poses a significant problem. Although artemisinin exerts antitumor effects, but its efficacy in anaplastic thyroid carcinoma is unknown.

Methods
We used RNA sequencing to identify differentially expressed genes. Next, we determined the cause of ART resistance by testing the expression and activity of β-catenin, and enhanced ART activity with a WNT signaling inhibitor.

Results
Artemisinin suppressed the growth of BHT-101 but not human thyroid anaplastic carcinoma (CAL-62) cells. The mechanism of artemisinin resistance in CAL-62 was associated with the aberrant activation of WNT signaling. Pyrvinium pamoate, an inhibitor of WNT signaling, was used to overcome ART resistance in CAL-62 cells. The combination of artemisinin and pyrvinium pamoate suppressed the growth of CAL-62 cells and induced the apoptosis.

Conclusions
Our study is the first to prove the efficacy of ART as monotherapy or in combination with PP in the management of anaplastic thyroid cancer, and that the inhibition of WNT signaling may overcome ART resistance.