bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organic farming - Deep genotyping reveals specific selection footprints in barley populations
Authors: Schneider Michael , Barbosa Marissa , Ballvora Agim , Leon Jens 
Published: March 2021

Abstract
Organic farming has the potential to tackle the imminent task of sustainable food production, if the yields could be raised. Here, the benefits of additional exotic alleles, the necessity of increased genetic heterogeneity in organically farmed systems and the buffering capacities by the pronounced plasticity of root traits are demonstrated. Two barley populations, naturally adapted for more than two decades to organic and conventional farming systems, were compared by a novel strategy of whole genome resequencing of pooled samples. Substantial allele frequency deviations between the farming systems were uncovered (for various agronomically relevant chromosomal regions) by testing multiple generations. In contrast to the organic adapted population, an early equilibrium in the conventional population was observed, accompanied reduced genetic diversity. Differences between the populations were revealed in root morphology, developmental processes and abiotic stress responses. These findings indicate that wild genetic resources play a critical role in the development of organically adapted varieties and distinct variations in ecosystems demand different genetic compositions.
Study of blood levels of Lactate, Vitamin D and Nucleated Red Blood Cells for early prediction of Hypoxic–Ischemic Encephalopathy: A cross-sectional case-control study
Authors: Saad Ahmed , thabet Ahmed , Soliman Mohamed , Abdel-Aziz Alyaa 
Published: March 2021

Abstract
Background

Perinatal asphyxia is a serious medical condition in which there is a lack of oxygen or blood flow during, or even after the labor process.
Methods

A cross-sectional case-control study was conducted on 20 neonates with HIE comprising the cases (APGAR ≤ 5) and another 20 neonates representing the control group with their age, sex, and weight matched, admitted to NICU. Sarnat score was used to assess the severity of HIE.
Results

Venous blood levels of lactate and nucleated red blood cells per 100 white blood cells (NRBC/100 WBC) counts were significantly higher in HIE neonates than in the control group with a highly significant difference (p-value < 0.001). While serum Vitamin D was significantly lower in the HIE group than in the control (p-value < 0.001).
Conclusion

Serum lactate level, vitamin D level and NRBCs/100 WBCs might be used as biomarkers in the early prediction of HIE.
Visitor’s willingness to pay for cultural ecosystem services in Bangladesh: an assessment for Lawachara National Park, a biodiversity hotspot
Authors: Saha Narayan , Mukul Sharif A. 
Published: March 2021

Abstract
The valuation of natural ecosystems helps policymakers in allocate adequate resources for the provision of ecosystem services they provide. Cultural ecosystem services are the non-material benefits we obtain from nature, which include but are not limited to recreation, aesthetic enjoyment, physical and mental health benefits. They are essential for a proper sense of a place, human health, and wellbeing. We quantified the recreational and other non-material benefits of Lawachara National Park (LNP), one of the oldest and most diverse forest protected area and touristic attractions in northeast Bangladesh. A Modified Travel Cost Method (MTCM) was applied for quantifying the recreational and other non-material values of LNP. Altogether 309 respondents were interviewed, covering both peak season and slack season. In our MTCM, we considered several additional factors, unlike the commonly used Travel Cost Method (TCM). The value of cultural ecosystem services of LNP was estimated to be Taka 1 476.70 million and Taka 476.44 million per annum using MTCM and TCM, respectively. The value estimated using MTCM was marginally higher than the value estimated using TCM and was due to the additional variables we considered in our modified approach. We believe our estimates using MTCM will guide policymakers to properly value natural ecosystems and facilitate adequate resource allocation for ecotourism in LNP and elsewhere.
Ursodeoxycholic Acid Suppresses The Malignant Progression of Colorectal Cancer Through TGR5-YAP Axis
Authors: Zhang Huan , Xu Huanji , Zhang Chenliang , Tang Qiulin , Bi Feng 
Published: March 2021

Abstract
Background: The Hippo/YAP pathway plays an important role in the development of cancers. Previous studies have reported that bile acids can activate YAP (Yes Associated Protein) to promote tumorigenesis and tumor progression. Ursodeoxycholic acid (UDCA) is a long-established old drug used for cholestasis treatment. So far, the effect of UDCA on YAP signaling in colorectal cancer (CRC) is not well defined. The study means to explore relationship of UDCA and YAP in CRC.Methods: The effect of UDCA on CRC cells proliferation was examined by MTT and clonogenic assay, western blotting (WB), real-time PCR, seperation of nucleoprotein and cytoplasmic protein and immunofluorescence (IF) assays were used to detect expression of YAP, WB, real-time PCR, GST-pull down assay and rhodamine-labeled phalloidin staining assays were used to detect activity of RhoA. After transfection of YAP5SA plasmids and RhoAV14 plasmids respectively, MTT, clonogenic assay, EdU incorporation assays and WB were performed. WB and ELISA were used to detect activity of cAMP/PKA axis, after blocking cAMP/PKA axis with siRNA and inhibitors, MTT, WB, IF and clonogenic assay were performed to test effect of UDCA on CRC cells. WB, IF and real-time PCR assays were used to detect expression of TGR5 in CRC cells after UDCA treatment, and then TGR5 agonist, TGR5 antagonist and siRNA were used to detect effect of UDCA on CRC cells. AOM/DSS-induced primary model was used to detect effect of UDCA, WB and Immunohistochemistry (IHC) were used to detect expression of related proteins.Results: UDCA suppressed YAP signaling by activating the membrane G‐protein‐coupled bile acid receptor (TGR5). TGR5 mainly regulated cAMP/PKA signaling pathway to inhibit RhoA activity, thereby suppressing YAP signaling. Moreover, the restoration of YAP expression alleviated the inhibitory effect of UDCA on CRC cell proliferation. In AOM/DSS-induced CRC model, UDCA inhibited tumor growth in a concentration-dependent manner and decreased expression of YAP and Ki67.Conclusion: UDCA plays a distinguished role in regulating YAP signaling and CRC growth from the primary bile acids and partial secondary bile acids, demonstrating the importance of maintaining normal intestinal bile acid metabolism in cancer patients. It also presents a potential therapeutic intervention for CRC.
Comparison of Major Bleeding Events of Uninterrupted Novel Oral Anticoagulants Versus Uninterrupted Vitamin K Antagonist During Catheter Ablation of Atrial Fibrillation: A Meta-analysis of Randomized Controlled Trials
Authors: Yang Qian , Chen Xuefeng , Zhai Jianlong , Dang Yi 
Published: March 2021

Abstract
Background: Previous meta-analyses comparing efficacy and safety of uninterrupted novel oral anticoagulants (NOACs) versus uninterrupted vitamin K antagonist (VKA) during catheter ablation (CA) of atrial fibrillation (AF) had no consensus in major bleeding, and didn’t perform subgroup analyses for different types of major bleeding events. This meta-analysis was performed to comprehensively evaluate the risk of major bleeding events of these two anticoagulant strategies during CA of AF.Methods: We searched online databases for randomized controlled trials that compared major bleeding events of uninterrupted NOACs and VKA during CA of AF up to January 2021. A fixed-effect model was used if the chi-squared test P-value was > 0.10 and I2 was < 50%, otherwise a random- effect model was used.Results: Six published studies including 2392 patients were identified for inclusion in the analysis. The overall incidence of major bleeding events was lower in the NOACs group than in the VKA group (OR = 0.56, 95% CI = 0.34 – 0.93, I2 = 38%, P = 0.15). Subgroup analyses showed that the incidence of severe puncture site complications was lower in the NOACs group than in the VKA group (OR = 0.53, 95% CI = 0.30 – 0.96, I2 = 16%, P = 0.32). But the incidence of cardiac tamponade (OR = 0.53, 95% CI = 0.23 – 1.26, I2 = 0%, P = 0.46), intracranial (OR = 0.25, 95% CI = 0.03 – 2.23, I2 = 0%, P = 0.82) and gastrointestinal bleeding (OR = 0.98, 95% CI = 0.18 – 5.39, I2 = 0%, P = 0.43) had no statistically significant differences between the two groups.Conclusion: This meta-analysis suggests that compared to uninterrupted VKA, uninterrupted NOACs are superior in major bleeding and severe puncture site complications during CA of AF, but are not superior in cardiac tamponade, intracranial and gastrointestinal bleeding.
Process Parameters Optimization for Thin-walled Tube Push-bending Using Response Surface Methodology
Authors: Xie Wenlong , Jiang Weihao , Wu Yunfeng , Song Hongwu , Deng Siying , Lăzărescu Lucian , Zhang Shihong , Banabic Dorel 
Published: March 2021

Abstract
In this paper, the response surface methodology (RSM) and finite element (FE) simulation were applied to optimize the push-bending process parameters of the thin-walled tube with polyurethane mandrel. The objective of the present work is to predict the optimal set of process parameters including the relative length of the mandrel (L/D), the friction coefficient between die and tube (μ1), the friction coefficient between polyurethane and tube (μ2) and Poisson’s ratio of polyurethane (υ) to obtain qualified bent tubes. Three empirical models were developed to describe the relationship between process parameters and quality parameters of the bent tubes. In addition, the significant factors affecting the forming quality were analyzed using analysis of variance (ANOVA) of each model. Response surfaces were constructed to study the effect of each process parameter on the quality of the bent tubes. Finally, the process optimization window with the maximum thinning rate (ϑ) less than 20%, the maximum thickening rate (ψ) less than 17%, and the maximum cross-section ovality (ξ) less than 5% of the bent tube was established. Qualified bent tubes with diameter of 144 mm, wall thickness of 2 mm, and bending radius of 280 mm were formed experimentally by following the established process window.
Perioperative Prophylactic Internal Iliac Artery Balloon Occlusion (Iiabo) in Placental Implantation Abnormalities
Authors: López-Benitez Ruben , Castillo Tomás Reyes Del , Hodel Markus , Lima Thiago VM , Kara Levent , Schmidt Magdalena , Roos Justus E. 
Published: March 2021

Abstract
BackgroundPlacental implantation abnormalities remain among the major causes of massive postpartum hemorrhage and maternal mortality worldwide. To avoid a hysterectomy, prophylactic management with perioperative internal iliac artery balloon occlusion (IIABO) could minimize blood loss and facilitate surgical performance through reductions in the rate of uterine perfusion. We aimed to evaluate the safety and efficacy of IIABO in patients with placental implantation abnormalities.ResultsThe study group consisted of 13 patients, including three patients with placenta previa totalis, seven patients with placenta increta, and three patients with placenta percreta. Prophylactic IIABO was performed in all patients. The median estimated blood loss was 700 ml ± 598.8 ml, the median number of red blood cell transfusion units was 0 ± 0.75, and only two patients required uterine artery embolization. The uterus was preserved in eight patients (61.5%), with an average intra-hospitalary stay of 6 ± 3.2 days. The average fetal radiation dose was 4.67 mGy. No complications were attributed to IIABO placement.ConclusionsThe prophylactic use of IIABO in placental implantation abnormalities is an effective and safe method of controlling perioperative bleeding during cesarean section and hysterectomy. Indications should be strictly controlled, and interdisciplinary planning and management are mandatory.
Gait biofeedback training in people with Parkinson’s disease: a pilot study
Authors: McMaster Kate , Cole Michael H , Chalkley Daniel , Creaby Mark W. 
Published: March 2021

Abstract
Background

People with Parkinson’s disease (PD) are at a high risk of falls, with ~ 60% experiencing a fall each year. Greater mediolateral head and pelvis motion during gait are known to increase the risk of falling in PD, however the ability to modify these aspects of gait has not been examined. Thus, this study aimed to examine whether mediolateral trunk, head and pelvis motion during walking could be successfully decreased in people with PD using real-time biofeedback.
Methods

Participants were provided with real-time biofeedback regarding their mediolateral trunk lean via a visual projection whilst walking along an 8-metre indoor walkway.
Using the feedback provided, they were
asked to reduce the magnitude of their mediolateral trunk
lean.

Gait was recorded for four conditions (i) Baseline, (ii) Intervention, (iii) immediately Post-Intervention, and (iv) one-week Follow-Up. Biomechanical variables associated with falls risk were compared between conditions, including normalised mediolateral motion, gait velocity and stride length.
Results

A reduction in mediolateral trunk lean, step length and gait velocity from Baseline to the Intervention and Post-intervention conditions was observed. Contrary to this, increased normalised ML pelvis and trunk motion was observed between the Baseline and Intervention conditions, but returned to Baseline levels in the Post-Intervention condition.
Conclusions

Results from the current study suggest that real-time visual biofeedback may be effective at modifying specific gait characteristics that are associated with falls in PD. Further research is required to better understand the influence of this intervention approach has upon falls incidence.
Trial Registration:

Australian New Zealand Clinical Trials Registry ACTRN12620000994987. Registered 10 June 2020 - Retrospectively registered, https://anzctr.org.au/Trial/Registration/TrialReview.aspx?id=380324.
Peer Supported Open Dialogue in the National Health Service: Implementing and Evaluating a New Approach to Mental Health Care
Authors: Kinane Catherine , Osborne James , Ishaq Yasmin , Colman Marcus , MacInnes Douglas 
Published: March 2021

Abstract
BackgroundOpen Dialogue, an approach to mental health care which is based on collaboration between an individual and their family and social network, originated in Western Lapland in the 1980’s and has been developing internationally. Our quest for better approaches to Mental Health Care with improved carer and service user experience led us to develop and test a model of Peer Supported Open Dialogue (POD). There is no research currently looking at the impact of a standalone POD model in an NHS community team so this study evaluates its implementation, clinical effectiveness and value to service users, their families and NHS staff. Method50 service users treated by the POD Team were recruited with additional participants from family and wider social network. Questionnaires covering wellbeing, functioning, satisfaction were collected through validated scales completed at baseline, three and six months. Data regarding adherence was collected following each network meeting. Data from electronic medical records was collected looking at functioning, contact rate, those in employment or full-time education and the mean bed days per episode of care between service users receiving POD compared to traditional services. Results Service users treated were young people with a mean age of 35 years, slightly more males than females. The approach was effective on service user reported measures of wellbeing and functioning. Clinician reported measure showed better outcomes than treatment as usual at the six month point. There was a marked increase in perceived support by carers which increased across the study. Over half the meetings were attended by carers. The POD group had greater face to face contact, longer contact times and an important clinical difference in the number of bed days used. Clinician adherence to the model was very high. The Community Mental Health Survey showed high satisfaction rates for service users including carer involvement.Conclusions It was possible to transform to deliver a clinically effective POD service in the NHS. This innovative approach provided continuity of care within the social network, with improved carer support and high satisfaction for service users, carers and clinicians.Trial registration: (isrctn.com/ISRCTN36004039. Retrospectively registered 04 January 2019.
Influence of Coal Gangue Mulching With Various Thicknesses and Particle Sizes on Soil Water Characteristics
Authors: Han Xiu-Na , Dong Ying , Geng Yu-qing , Li Na , Zhang Chao-Ying 
Published: March 2021

Abstract
Water availability seriously affects vegetation restoration in arid mining areas, and mulching is an effective way to improve soil water conditions. Coal gangue occupies large swathes of land resources, resulting in ecological fragility and various environmental problems. Despite coal gangue having mineral elements similar to those in soil, its potential function as a mulch for soil water conservation has been unclear. Herein, mulching on the surfaces of soil columns was conducted using four particle size ranges and four thicknesses under laboratory conditions to investigate water infiltration and evaporation under different conditions. Apart from the treatments with particle size of 0–0.5 cm, the remaining mulch treatments with 16 cm thickness involved greater infiltration and lower evaporation. Therefore, we recommend a 16 cm-thick mulch treatment as the preferred mulching style. Treatments with a particle size of 0–0.5 cm and those with 4-cm thickness are not suggested due to their lower infiltration and higher evaporation characteristics. Overall, to enhance the soil water storage capacity in mining areas, the results suggest that mulching coal gangue with particle size exceeding 0.5 cm and a thickness exceeding 8 cm is suitable.
Numerical Evaluation of the Performances of the Ventilation System in a Blast Furnace Casthouse
Authors: Wang Hui , Wang Tianying , Liu liuchan , Long Zhengwei , Zhang Pu 
Published: March 2021

Abstract
The blast furnace casthouse is a typical heavy-polluting factory building of a steel enterprise. During the tapping process and the taphole opening, the dust concentration in the factory building's workroom can reach tens of thousands mg/m³. Over time, the air pollutants in the workplace can have unwanted consequences on employees' health. This paper selected a typical blast furnace tapping workshop and measured on-site the characteristics of the wind speed distribution, temperature distribution, and soot concentration distribution during the taping period. A numerical simulation model was established to analyze the taphole smoke exhaust system's performance based on computational fluid dynamics. The findings are: the velocity, temperature, and smoke density distributions in the workplace were very uneven, and the thermal comfort of the workers' area was relatively poor. Also, the concentration of PM2.5 was mostly below 80μg/m³. Besides, due to the plant's on-site measurement, real data was obtained for numerical simulation verification, making the evaluation of the entire plant's ventilation performance more reliable. Hence, this article's finding provides a scientific basis for optimizing the air distribution in the blast furnace cast house's workplace.
The Effect of Magnetic Field on the Dynamics of Gas Bubbles in Water Electrolysis
Authors: Li Yan-Hom , Chen Yen-Ju 
Published: March 2021

Abstract
In this work, the movement of the gas bubbles evolved from the platinum electrodes in the influence of various magnetic field configurations are experimentally investigated. The oxygen and hydrogen bubbles respectively evolve from the surface of anode and cathode have distinctive behaviors in the presence of magnetic fields due to their paramagnetic and diamagnetic characteristics. The magnetic field perpendicular to the surface of the horizontal electrode induces the revolution of the bubbles. The opposite revolution direction between the oxygen and hydrogen bubbles cause the swirling of the flow and spread out the bubbles between the electrode which enhances the conductivity and electrolysis effectiveness. On the other hand, the vertical electrodes in the influence of a parallel magnetic field induce horizontal Lorentz force which effectively spells out the bubbles and increases the conductivity and electrolysis effectiveness as well. However, when the layouts of the electrode and magnetic field result in upward or downward Lorentz forces which competes with the buoyancy force, the sluggish flow in the duct would hinder the movement of the bubbles and decrease the conductivity and charging performance. This phenomenon affects the corresponding natural convection and mass transport as well. These results propose the optimal layout of the electrode and magnetic field which is useful to enhance the conductivity or the effectiveness in water electrolysis.
Mechanism of the Fungal-like Particles in the Inhibition of Adipogenesis in 3t3-l1 Adipocytes
Authors: Jakkawanpitak Chanawee , Inafuku Masashi , Oku Hirosuke , Hutadilok-Towatana Nongporn , Bunkrongcheap Ruthaiwan , Sermwittayawong Natthawan , Aiemchareon Piyapat , Sermwittayawong Decha 
Published: March 2021

Abstract
The dynamic ability of adipocytes in adipose tissue to store lipid in response to changes in the nutritional input and inflammatory elicitors has a major impact on human health. Previously, we established laminarin-coated beads or LCB as an inflammatory elicitor for adipocytes. However, it was not clear whether LCB inhibits lipid accumulation in adipocytes. Here, we show that LCB acts in the early stage of adipogenesis through both IRAK and SYK pathways, resulting in the activation of the AMPK and NF-kB complexes, which subsequently cause cell cycle arrest, suppression of C/EBPb, PPARg, C/EBPa, FAS, FABP4, and ACC proteins, downregulation of other transcription factors and enzymes, such as Pparg, C/ebpa, Srebp-1, Lpl, and Fas gene expression, inhibition of adipogenesis, and stimulation of an inflammatory response. Unlike the inhibition of adipogenesis, LCB could stimulate an inflammatory response at any stage of differentiation. In addition, we find that Tlr2 and Clec7a/Dectin-1 but not Tlr4 and Cd36 gene expression are upregulated upon the treatment with LCB, suggesting that TLR2 and CLEC7A/Dectin-1 might be the b-glucan receptors for the cells. Together, we present the mechanism of LCB, as fungal-like particles, that elicit an inflammatory response and inhibit adipogenesis at the early stage of differentiation.