bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulation of Martian Dust Effects on Polar CO2 Ice Caps and Atmospheric Circulation Using the MarsWRF Model
Authors: Zhao Yang , Zhong Lei , Yuan Renming , Zhao Chun , Li Rui , Wang Yu , Lian Yuan , Richardson Mark 
Published: December 2021

AbstractMartian dust plays an important role in modulating climate. However, the effects of dust on polar CO2 ice caps, atmospheric circulation processes and the relationship between them are not yet clear. In this study, a Mars general circulation model (MarsWRF) was applied to investigate the impacts of the magnitude and timing of Martian dust storms on the spatiotemporal characteristics of polar CO2 ice caps and atmospheric circulation. The results show that dust can inhibit the sublimation of southern CO2 ice through the radiation effect. Under the “High Dust” scenario, the ice edge can extend up to 5° more equatorward than that under the “Standard” scenario around Ls = 220°. The extent of northern CO2 ice cap is hardly affected by dust because the impacts induced by dust mainly appear north of 80°N. By shifting the timing of maximum dust loading during the dust season, the "Early Dust" scenario inhibits the sublimation of the southern ice cap, while the "Late Dust" scenario accelerates the sublimation process. In addition, the variations in dust loading strength can lead to changes in three near‐surface wind belts, which are related to intensified Hardly circulation. The appearance of the warming vortex under the "Early Dust" scenario is delayed, and its intensity is 60 K lower than that observed in the "High Dust" and "Late Dust" scenarios. When dust loading increases, the northern CO2 condensation process in the Western Hemisphere accelerates, which is due to the increased pole‐to‐equator temperature gradient and the increased meridional wind speed.
Paleoclimate Evolution on Titan After Episodic Massive Methane Outgassing Simulated by a Global Climate Model
Authors: Tokano Tetsuya , Lorenz Ralph D. 
Published: December 2021

AbstractTitan's paleoclimate after the onset of the putative last major methane outgassing event 700 Myr ago is simulated by a global climate model. If the atmosphere was methane‐depleted prior to outgassing, outgassed methane initially causes warming due to increased greenhouse effect. Further outgassing leads to methane snowfall, which in turn cools the troposphere and surface by an ice‐albedo feedback and thereby initiates a lengthy ice age. Formation of ice sheets begins in the polar region, but with increasing methane inventory the entire globe is eventually covered by surface methane frost as thick as 100 m, with local accumulation on elevated terrains. Among various time‐dependent input parameters the methane inventory by far exerts the greatest control over the climate evolution. As Titan's climate transitions from a dry state via a partially ice‐covered state to a globally ice‐covered state, the circulation and precipitation pattern change profoundly and the tropospheric temperature further decreases. Globally ice‐covered snowball Titan is characterized by weak meridional circulation, weak seasonality and widespread snowfall. Frost ablation begins after the end of outgassing due to photochemical destruction of atmospheric methane. It is conceivable that Titan's polar seas resulted from melting of the polar caps within the past 10 Myr and subsequent drainage to the polar basins. Surface methane frost could only melt when the frost retreated to the polar region, which led to global warming by lowering of the surface albedo at low latitudes and increased greenhouse effect.
Machine‐Learning Research in the Space Weather Journal: Prospects, Scope, and Limitations
Authors: Lugaz Noé , Liu Huixin , Hapgood Mike , Morley Steven 
Published: December 2021

AbstractManuscripts based on machine‐learning techniques have significantly increased in Space Weather over the past few years. We discuss which manuscripts are within the journal's scope and emphasize that manuscripts focusing purely on a forecasting technique (rather than on understanding and forecasting a phenomenon) must correspond to a substantial improvement over the current state‐of‐the‐art techniques and present this comparison. All manuscripts shall include information about data preparation, including splitting of data between training, validation and testing sets. The software and/or algorithms used for to develop the machine‐learning technique should be included in a repository at the time of submission. Comparison with published results using other methods must be presented, and uncertainties of the forecast results must be discussed.
A New Method for Fault‐Scarp Detection Using Linear Discriminant Analysis in High‐Resolution Bathymetry Data From the Alarcón Rise and Pescadero Basin
Authors: Vega‐Ramírez L. A. , Spelz R. M. , Negrete‐Aranda R. , Neumann F. , Caress D. W. , Clague D. A. , Paduan J. B. , Contreras J. , Peña‐Dominguez J. G. 
Published: December 2021

AbstractThe linear discriminant analysis (LDA) is a common technique used in machine learning and pattern recognition for dimensionality reduction problems. Here, the LDA is applied to detect faults‐scarps in high‐resolution bathymetric profiles in the Southern Pescadero Basin (SPB) in the Gulf of California. The LDA uses fault scarps and cuestas (sloping topography) identified by a geomorphologist in the neighboring Alarcón Rise (AR). These geometric representations are transformed into a parametric space by an idealized fault‐scarp degradation model. Through inversion, we extracted the product of the mass diffusion coefficient with time (τ), scarp height (u0), and goodness of fit of the model on the scarp profiles and cuestas (ε). The LDA transforms the parametric space τ, u0, ε by the Fisher’s criterion into a 1D dimensional space that maximizes separability of classes. Then, the classification is performed by Bayes decision rule using the probability density functions (PDF) built from the 1D projected data for each class (fault‐scarps and cuestas). The implementation results in cross‐sectional profiles across the SPB show the ability to detect faults in the deepest part of the basin where the flat basin floor is interrupted by morphologically young fault‐scarp arrays. The LDA interpretation outperforms manual identification, particularly in faults scarps that are longer than ∼3 km, whereas shorter faults are challenging to discern from other linear features like channels. The model can extract information about the state of degradation of the scarps. This application allows the identification of fault generation episodes and resolves kinematic interactions between faults.
COVID-19 presents an opportunity for dental teams to become ready for person-centred care
Authors: Asimakopoulou Koula , Mills Ian , Neville Patricia , Scambler Sasha 
Published: December 2021

AbstractTwo publications that recently appeared in the British Dental Journal mooted the position that dentistry may not be ready for person-centred care. This commentary takes up this discussion and agrees that while person-centred care is essential to dentistry, it is not without its challenges. Drawing on the multidisciplinary expertise of its authors (two sociologists, one psychologist and a dentist), the nature of these challenges is interrogated further. It also identifies opportunities for change on this position from within the literature, as well as by clinical practice. We present evidence to suggest that the current pandemic has shown that dental teams are capable of rising to a challenge and adapting to change. In this light, we propose that the pandemic presents dental teams with an opportunity to be even more person-centred.
Impact of KRAS, BRAF and microsatellite instability status after cytoreductive surgery and HIPEC in a national cohort of colorectal peritoneal metastasis patients
Authors: Larsen S. G. , Goscinski M. A. , Dueland S. , Steigen S. E. , Hofsli E. , Torgunrud A. , Lund-Iversen M. , Dagenborg V. J. , Flatmark K. , Sorbye H. 
Published: December 2021

Abstract
Background
Patients with metastatic colorectal cancer (mCRC) carrying BRAF (mutBRAF) or KRAS mutation (mutKRAS) have an inferior prognosis after liver or lung surgery, whereas the prognostic role in the context of peritoneal metastasis (PM) after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has been less investigated.

Methods
In total, 257 patients with non-appendiceal PM-CRC were included from the Norwegian National Unit for CRS-HIPEC.

Results
In total, 180 patients received CRS-HIPEC with Mitomycin C, 77 patients received palliative surgery only. In the CRS-HIPEC group, mutBRAF was found in 24.7%, mutKRAS 33.9% and double wild-type 41.4% without differences in survival. MSI was found in 29.3% of mutBRAF cases. Patients with mutBRAF/MSI had superior 5-year survival compared to mutBRAF with MSS (58.3% vs 25.2%, P = 0.022), and better 3-year disease-free survival (DFS) compared to mutKRAS (48.6% vs 17.2%, P = 0.049). Peritoneal Cancer Index and the number of lymph node metastasis were prognostic for OS, and the same two, location and gender prognostic for DFS in multivariate analysis.

Conclusions
PM-CRC with CRS-HIPEC patients has a surprisingly high proportion of mutBRAF (24.7%). Survival was similar comparing mutBRAF, mutKRAS and double wild-type cases, whereas a small subgroup with mutBRAF and MSI had better survival. Patients with mutBRAF tumours and limited PM should be considered for CRS-HIPEC.
Accurate detection of circulating tumor DNA using nanopore consensus sequencing
Authors: Marcozzi Alessio , Jager Myrthe , Elferink Martin , Straver Roy , van Ginkel Joost H. , Peltenburg Boris , Chen Li-Ting , Renkens Ivo , van Kuik Joyce , Terhaard Chris , de Bree Remco , Devriese Lot A. , Willems Stefan M. , Kloosterman Wigard P. , de Ridder Jeroen 
Published: December 2021

AbstractLevels of circulating tumor DNA (ctDNA) in liquid biopsies may serve as a sensitive biomarker for real-time, minimally-invasive tumor diagnostics and monitoring. However, detecting ctDNA is challenging, as much fewer than 5% of the cell-free DNA in the blood typically originates from the tumor. To detect lowly abundant ctDNA molecules based on somatic variants, extremely sensitive sequencing methods are required. Here, we describe a new technique, CyclomicsSeq, which is based on Oxford Nanopore sequencing of concatenated copies of a single DNA molecule. Consensus calling of the DNA copies increased the base-calling accuracy ~60×, enabling accurate detection of TP53 mutations at frequencies down to 0.02%. We demonstrate that a TP53-specific CyclomicsSeq assay can be successfully used to monitor tumor burden during treatment for head-and-neck cancer patients. CyclomicsSeq can be applied to any genomic locus and offers an accurate diagnostic liquid biopsy approach that can be implemented in clinical workflows.
Suppressed-moment 2-k order in the canonical frustrated antiferromagnet Gd2Ti2O7
Authors: Paddison Joseph A. M. , Ehlers Georg , Cairns Andrew B. , Gardner Jason S. , Petrenko Oleg A. , Butch Nicholas P. , Khalyavin Dmitry D. , Manuel Pascal , Fischer Henry E. , Zhou Haidong , Goodwin Andrew L. , Stewart J. Ross 
Published: December 2021

AbstractIn partially ordered magnets, order and disorder coexist in the same magnetic phase, distinct from both spin liquids and spin solids. Here, we determine the nature of partial magnetic ordering in the canonical frustrated antiferromagnet Gd2Ti2O7, in which Gd3+ spins occupy a pyrochlore lattice. Using single-crystal neutron-diffraction measurements in applied magnetic field, magnetic symmetry analysis, inelastic neutron-scattering measurements, and spin-wave modeling, we show that its low-temperature magnetic structure involves two propagation vectors (2-k structure) with suppressed ordered magnetic moments and enhanced spin-wave fluctuations. Our experimental results are consistent with theoretical predictions of thermal fluctuation-driven order in Gd2Ti2O7, and reveal that inelastic neutron-scattering measurements on powder samples can solve the longstanding problem of distinguishing single-k and multi-k magnetic structures.
Sex differences in innate anti-viral immune responses to respiratory viruses and in their clinical outcomes in a birth cohort study
Authors: Regis Eteri , Fontanella Sara , Lin Lijing , Howard Rebecca , Haider Sadia , Curtin John A. , Edwards Michael R. , Rattray Magnus , Simpson Angela , Custovic Adnan , Johnston Sebastian L. 
Published: December 2021

AbstractThe mechanisms explaining excess morbidity and mortality in respiratory infections among males are poorly understood. Innate immune responses are critical in protection against respiratory virus infections. We hypothesised that innate immune responses to respiratory viruses may be deficient in males. We stimulated peripheral blood mononuclear cells from 345 participants at age 16 years in a population-based birth cohort with three live respiratory viruses (rhinoviruses A16 and A1, and respiratory syncytial virus) and two viral mimics (R848 and CpG-A, to mimic responses to SARS-CoV-2) and investigated sex differences in interferon (IFN) responses. IFN-α responses to all viruses and stimuli were 1.34–2.06-fold lower in males than females (P = 0.018 −  < 0.001). IFN-β, IFN-γ and IFN-induced chemokines were also deficient in males across all stimuli/viruses. Healthcare records revealed 12.1% of males and 6.6% of females were hospitalized with respiratory infections in infancy (P = 0.017). In conclusion, impaired innate anti-viral immunity in males likely results in high male morbidity and mortality from respiratory virus infections.
The neural basis of authenticity recognition in laughter and crying
Authors: Kosilo Maciej , Costa Mónica , Nuttall Helen E. , Ferreira Hugo , Scott Sophie , Menéres Sofia , Pestana José , Jerónimo Rita , Prata Diana 
Published: December 2021

AbstractDeciding whether others’ emotions are genuine is essential for successful communication and social relationships. While previous fMRI studies suggested that differentiation between authentic and acted emotional expressions involves higher-order brain areas, the time course of authenticity discrimination is still unknown. To address this gap, we tested the impact of authenticity discrimination on event-related potentials (ERPs) related to emotion, motivational salience, and higher-order cognitive processing (N100, P200 and late positive complex, the LPC), using vocalised non-verbal expressions of sadness (crying) and happiness (laughter) in a 32-participant, within-subject study. Using a repeated measures 2-factor (authenticity, emotion) ANOVA, we show that N100’s amplitude was larger in response to authentic than acted vocalisations, particularly in cries, while P200’s was larger in response to acted vocalisations, particularly in laughs. We suggest these results point to two different mechanisms: (1) a larger N100 in response to authentic vocalisations is consistent with its link to emotional content and arousal (putatively larger amplitude for genuine emotional expressions); (2) a larger P200 in response to acted ones is in line with evidence relating it to motivational salience (putatively larger for ambiguous emotional expressions). Complementarily, a significant main effect of emotion was found on P200 and LPC amplitudes, in that the two were larger for laughs than cries, regardless of authenticity. Overall, we provide the first electroencephalographic examination of authenticity discrimination and propose that authenticity processing of others’ vocalisations is initiated early, along that of their emotional content or category, attesting for its evolutionary relevance for trust and bond formation.
miR1908-5p regulates energy homeostasis in hepatocyte models
Authors: Soubeyrand Sébastien , Lau Paulina , Beehler Kaitlyn , McShane Kelsey , McPherson Ruth 
Published: December 2021

AbstractWe previously identified genomic variants that are quantitative trait loci for circulating miR-1908-5p and then showed this microRNA to causally associate with plasma levels of LDL-C, fasting blood glucose and HbA1c. The link to LDL-C was subsequently validated and clarified by the identification of a miR1908-5p-TGFB-LDLR regulatory axis. Here, we continue our investigations on miR1908-5p function by leveraging human primary hepatocytes and HuH-7 hepatoma models. Expression of miR1908-5p was shown to be sensitive to glucose and agents affecting glucose metabolism. Transcriptome-wide changes in primary hepatocytes and HuH-7 cells treated with a miR1908-5p mimic were investigated by enrichment approaches to identify targeted transcripts and cognate pathways. Significant pathways included autophagy and increased mitochondrial function. Reduced activation and/or levels of several key energy and metabolic regulators (AKT, mTOR, ME1, G6PD, AMPK and LKB) were subsequently confirmed in mimic treated HuH-7 cells. These effects were associated with reduced NADPH to NADP+ ratio in HuH-7 cells. LKB1 was validated as a direct target of miR1908-5p, the reintroduction of which was however insufficient to compensate for the impact of the miR1908-5p mimic on AMPK and ACC1. These findings implicate miR1908-5p in metabolic and energy regulation in hepatocyte models via multiple, independent, pathways.
Short-term changes in retinal and choroidal relative flow volume after anti-VEGF treatment for neovascular age-related macular degeneration
Authors: Calzetti Giacomo , Mora Paolo , Borrelli Enrico , Sacconi Riccardo , Ricciotti Guido , Carta Arturo , Gandolfi Stefano , Querques Giuseppe 
Published: December 2021

AbstractThe effects of anti-vascular endothelial growth factor (anti-VEGF) agents on the native ocular vasculature are poorly understood. This pilot study aimed to assess short-term changes in retinal and choroidal perfusion after anti-VEGF treatment for neovascular exudative age-related macular degeneration (nAMD) using the relative flow volume (RFV) parameter derived from laser speckle flowgraphy. Ten treatment-naïve nAMD patients underwent measurements of mean, maximum, minimum, and differential RFV within a retinal arteriolar segment and a choroidal vessel segment outside the neovascular area. Measurement of retinal RFV (rRFV), choroidal RFV (cRFV), and subfoveal choroidal thickness (SCT) was repeated 9 and 35 days after a single anti-VEGF injection. The treatment caused a statistically significant decrease in the mean rRFV, mean cRFV, and SCT during the follow-up (p < 0.05). At the intermediate visit, the mean cRFV and SCT were − 17.6% and − 6.4% compared to baseline, respectively. However, at the final measurement, the mean cRFV was not different from the baseline value, which indicated waning of the anti-VEGF effect. In conclusion, a single anti-VEGF injection in treatment-naïve nAMD resulted in a decrease in retinal arteriolar and choroidal perfusion, according to the RFV parameter, which is a promising tool to simultaneously assess retinal and choroidal perfusion changes in response to anti-VEGF therapy.
Southeast Asian protected areas are effective in conserving forest cover and forest carbon stocks compared to unprotected areas
Authors: Graham Victoria , Geldmann Jonas , Adams Vanessa M. , Negret Pablo Jose , Sinovas Pablo , Chang Hsing-Chung 
Published: December 2021

AbstractProtected areas aim to conserve nature, ecosystem services, and cultural values; however, they have variable success in doing so under high development pressure. Southeast Asian protected areas faced the highest level of human pressure at the turn of the twenty-first century. To estimate their effectiveness in conserving forest cover and forest carbon stocks for 2000–2018, we used statistical matching methods to control for the non-random location of protected areas, to compare protection against a matched counterfactual. We found Southeast Asian protected areas had three times less forest cover loss than similar landscapes without protection. Protected areas that had completed management reporting using the Management Effectiveness Tracking Tool (METT) conserved significantly more forest cover and forest carbon stocks than those that had not. Management scores were positively associated with the level of carbon emissions avoided, but not the level of forest cover loss avoided. Our study is the first to find that METT scores could predict the level of carbon emissions avoided in protected areas. Given that only 11% of protected areas in Southeast Asia had completed METT surveys, our results illustrate the need to scale-up protected area management effectiveness reporting programs to improve their effectiveness for conserving forests, and for storing and sequestering carbon.
Incidence and risk factor of allergic contact dermatitis to 2-octyl cyanoacrylate and n-butyl cyanoacrylate topical skin adhesives
Authors: Park Young Hwan , Choi Jeong Seok , Choi Jung Woo , Kim Hak Jun 
Published: December 2021

AbstractAlthough the use of topical skin adhesives has increased as an alternative to conventional skin closure methods, studies on the incidence and risk factors of allergic contact dermatitis (ACD) to topical skin adhesives have been limited. The purpose of this study was to investigate the incidence and risk factors of ACD after the use of 2-octyl cyanoacrylate and n-butyl cyanoacrylate topical skin adhesives. We retrospectively reviewed 1145 patients (739 patients with 2-octyl cyanoacrylate and 406 patients with n-butyl cyanoacrylate) who underwent skin closure with topical skin adhesives. Variables suspected to correlate with ACD were retrieved from medical records and analyzed to determine risk factors. The incidence of ACD from the use of 2-octyl cyanoacrylate and n-butyl cyanoacrylate topical skin adhesives was 2.7% and 2.2%, respectively. There was no statistically significant difference in the incidence between the two ingredients. In logistic regression analysis, none of the variables were found to increase the risk of ACD in both 2-octyl cyanoacrylate and n-butyl cyanoacrylate topical skin adhesives. As ACD occurs without risk factors in 2–3% of patients who used 2-octyl cyanoacrylate or n-butyl cyanoacrylate topical skin adhesives, clinicians and patients should be aware of these facts before using topical skin adhesives.