bluuebunny/crossref_metadata_2025_split huggingface dataset:
Life-threatening ventricular arrhythmia and left ventricular dysfunction associated with anti-mitochondrial antibody-positive myositis: a case report
Authors: Hasegawa Yuki , Izumi Daisuke , Kashimura Takeshi , Minamino Tohru 
Published: December 2021

Abstract

Background
Anti-mitochondrial antibody (AMA)-positive myositis is an atypical inflammatory myopathy characterized by chronic progression of muscle atrophy and cardiac involvement. Few detailed reports have shown the clinical course of the cardiac complications of AMA-positive myositis.

Case summary
A 47-year-old man presented with shortness of breath on exertion. Cardiac dilatation was visible on chest X-ray, and echocardiography demonstrated diffuse hypokinesis with a reduced left ventricular (LV) ejection fraction of 30%. He had mild muscle weakness in the bilateral iliopsoas muscles, and his creatine kinase (CK) and anti-mitochondrial M2 antibody levels were elevated. A liver biopsy showed no findings of primary biliary cholangitis. Coronary angiography revealed normal coronary arteries. An endomyocardial biopsy showed interstitial fibrosis and marked degeneration of the mitochondria. Fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography showed circumferential abnormal accumulation in the LV myocardium, and he was diagnosed with cardiomyopathy associated with AMA-positive myositis. Optimal drug therapy for heart failure was started, and a cardiac resynchronization therapy-defibrillator was implanted. However, his cardiac function did not improve, and he was hospitalized due to ventricular tachycardia storm 5 years after the diagnosis. Ventricular tachycardia was terminated by radiofrequency catheter ablation on the LV-anterior papillary muscle. Steroid therapy was initiated and resulted in a decreased uptake of FDG and a normalized CK level at 3 months after his second discharge; however, LV systolic dysfunction remained 1 year later.

Discussion
Anti-mitochondrial antibody-positive myositis can affect the myocardium and cause severe LV dysfunction and life-threatening ventricular arrhythmia over time.

Keywords
Anti-mitochondrial antibody-positive myositis • Endomyocardial biopsy • Ventricular tachycardia • Left ventricular dysfunction • Case report • Magnetic resonance imaging • Near-infrared spectroscopy-intravascular ultrasound
Protective Effects of Familial Longevity Decrease With Age and Become Negligible for Centenarians
Authors: Gavrilova Natalia S , Gavrilov Leonid A 
Published: December 2021

AbstractIt is known that biological relatives of long-lived individuals demonstrate lower mortality and longer life span compared to relatives of shorter-lived individuals, and at least part of this advantage is likely to be genetic. Less information, however, is available about effects of familial longevity on age-specific mortality trajectories. We compared mortality patterns after age 50 years for 10 045 siblings of US centenarians and 12 308 siblings of shorter-lived individuals (died at age 65 years). Similar comparisons were made for sons and daughters of longer-lived parents (both parents lived 80 years and more) and shorter-lived parents (both parents lived less than 80 years) within each group of siblings. Although relatives of longer-lived individuals have lower mortality at younger ages compared to relatives of shorter-lived individuals, this mortality advantage practically disappears by age 100 years. To validate this observation further, we analyzed the survival of 3 408 US centenarians born in 1890–1897 with known information on maternal and paternal life span. We found using the Cox proportional hazards model that both maternal and paternal longevity (life span 80+ years) is not significantly associated with survival after age 100 years. The results are compatible with the predictions of reliability theory of aging suggesting higher initial levels of system redundancy (reserves) in individuals with protective familial/genetic background and hence lower initial mortality. Heterogeneity hypothesis is another possible explanation for the observed phenomena.
Spiritual Support Among African American and Caucasian ADRD Caregivers: A Risk and Resilience Study
Authors: Wilks Scott , Spurlock Wanda , Brown Sandra , Geiger Jennifer , Choate Sarah , Kirsch Katherine , Thompson Alisha , Slaton Cassie 
Published: December 2021

Abstract
Research shows African Americans at greater risk of developing Alzheimer’s disease and related dementias (ADRD) compared to Caucasians, suggesting African American ADRD caregivers are rising in numbers at a greater rate than Caucasian counterparts. A recent study indicated spiritual wellbeing differences among these caregiver groups. Using a quasi-follow-up of members of a larger caregiver sample, the purpose of this study was to test spiritual support as a moderator via a risk-and-resilience framework. Secondary data analysis from a sample of 691 ADRD caregivers examined data on demographics and standardized measures of spiritual support, caregiver burden, and psychological resilience. One-third of the sample reported as African American. Resilience negatively regressed, though not significantly, on caregiving burden among both groups. Spiritual support positively, significantly impacted resilience among both groups, slightly stronger among African Americans. Spiritual support did not significantly moderate risk with either group. Implications for professional healthcare practice are discussed.
Associations Among Personality Traits, Stress Experiences, and Physical and Cognitive Outcomes in Older Adults
Authors: Graham Eileen , Almeida David 
Published: December 2021

Abstract
Understanding between and within person variability in personality traits, and the processes of general and perceived stress are essential to understanding how to optimize cognitive health in older adults. It is well known that there is large variation in cognitive change: the pace and direction of change differs greatly across individuals. Personality traits and stress experiences are key factors that may account for some of these individual differences. The goal of our symposium is to present novel research in this area and discuss the implications for understanding personality, stress, and cognitive decline. First, Ferguson and colleagues will present a novel approach to assessing daily variability in personality. Their results demonstrate that daily personality assessments are able to capture within-person variability in personality, which could potentially help predict health trajectories in later adulthood. This is an important step in the study of change processes. Second, Luo and colleagues will present the factor structure of general and perceived stress, and show the predictive utility of these factors on physical and cognitive health outcomes. Third, Lawson and colleagues will discuss the extent to which personality is associated with cognitive function in a large sample of Mexican-origin adults. Fourth, Graham and colleagues will present results from a coordinated analysis that addressed associations among personality traits and cognitive decline both pre- and post- dementia diagnosis. Discussant David Almeida will contextualize these new findings and propose next steps.
On Being Ageist, Age-Friendly, Age-Inclusive: Differentiating Core Constructs and Their Implications
Authors: Montepare Joann 
Published: December 2021

Abstract
The pioneering Age-Friendly University (AFU) initiative has called for institutions of higher education to respond to the needs of older, more age-diverse populations through new approaches to programs, practices, and partnerships. In exploring in more detail what it means for a campus to be age-friendly, the national AFU Inventory and Campus Climate Survey (ICCS) study has raised questions about how core theoretical concepts are defined and manifested. Using observations from the ICCS study, this presentation will discuss tensions among constructs (e.g., does being age-friendly indicate the absence of ageist attitudes; are age-inclusive practices by design age-friendly?) and how differentiating these constructs better can help higher education focus its efforts in more intentional and productive ways.
Social Participation and the Risk for Developing Mild Cognitive Impairment and Dementia Among Older Adults
Authors: Eymundsdottir Hrafnhildur , Sigurdardottir Sigurveig , Ramel Alfons , Jonsson Palmi , Gudnason Vilmundur , Launer Lenore , Chang Milan 
Published: December 2021

Abstract
Introduction: We aim to investigate the longitudinal associations between social participation and the risk of developing mild cognitive impairment (MCI|) and dementia over 5 years of follow-up among cognitively normal older adults. Methods: A total of 2802 participants had complete follow-up data from Age-Gene/Environment-Susceptibility-Reykjavik-Study. Social participation was assessed by a questionnaire asking the frequency of contact with children, relatives, friends and neighbors. MCI and dementia were diagnosed according to international guidelines and by a team composed of a geriatrician, neurologist, neuropsychologist, and neuroradiologist. Logistic regression analysis was used to assess the associations. Results: At baseline 8% (n=225) reported no social participation. Among cognitively normal participants at baseline, 5.6% (n=243) developed mild cognitive impairment and 2.4% (n= 103) developed dementia during a mean follow-up time of 5.2 years. After full adjustment with covariates including age, gender, education, marital status, vitamin D levels, depression and APOE ε4, those with no social participation at baseline were significantly more likely to develop MCI at follow-up (OR=1.953, P=0.001). However, social participation at baseline was not associated with higher dementia diagnosis at follow-up (OR= 1.490, P=0.194). Conclusions: Community-dwelling old adults who are socially inactive are more likely to develop MCI than those who are socially active. Social participation might independently indicate impending changes in cognitive function among older adults.
Predictors of Disenrollment Among Medicare Fee-for-Service Beneficiaries With Dementia
Authors: Rivera-Hernandez Maricruz , Castillo Aaron , Trivedi Amal 
Published: December 2021

Abstract
Medicare enrollment among people with Alzheimer’s Disease and Related Dementias (ADRD) has reached an all-time high with about 12% of beneficiaries having an ADRD diagnosis. The federal government has special interest in providing healthcare alternatives for Medicare beneficiaries. However, limited studies have focused on understanding disenrollment from fee-for-service, especially among those with high-needs. In this study we identified predictors of disenrollment among beneficiaries with ADRD. We used the 2017-2018 Medicare Master Beneficiary Summary File to determine enrollment, sociodemographic, clinical characteristics and healthcare utilization. We included all fee-for-service beneficiaries enrolled in 2017 who survived the first quarter of 2018. Our primary outcome was disenrollment from fee-for-service between 2017 and 2018. Regression models included age, sex, race/ethnicity, dually eligibility to Medicare and Medicaid, chronic and disabling conditions (categorized by quartiles), total health care costs including outpatient, inpatient, post-acute care and other costs (categorized by quartiles) and county fixed-effects. There were 1,797,047 beneficiaries enrolled in fee-for-service with an ADRD diagnosis. Stronger predictors of disenrollment included race/ethnicity and dual eligibility. Disenrollment rates were 7.9% (95% CI, 7.2 – 8.5) among African Americans, 6.6 (95% CI, 6.2 – 7.0) among Hispanics and 4.3 (95% CI, 4.2 – 4.3) among Whites. Duals were 1.9% (95% CI, 1.4 – 2.3) more likely to disenroll from fee-for-service to Medicare Advantage (MA). The inclusion of MA special need plans and additional benefits for those with ADRD and complex chronic conditions may be valuable for those beneficiaries with ADRD, and who may not have Medigap coverage when enrolling in fee-for-service.
Factors Associated With Older Adults’ In-Hospital Mobility: A Comparison Between Israel and Denmark
Authors: Zisberg Anna , Petersen Janne , Andersen Ove , Shadmi Efrat , Shulyaev Ksenya , Gil Efrat , Agmon Maayan , Pedersen Mette Merete 
Published: December 2021

Abstract
Low levels of in-hospital mobility and excessive bed rest are widely described across the globe as a major risk factor for hospital associated disabilities. Different predictors of in-hospital and post-discharge mobility limitations have been proposed across studies, including age, admission diagnosis, physical performance, cognitive impairment, performance of activities of daily living, and length of stay. However, it is unknown whether similar risk factors across countries are associated with in-hospital mobility given different mobility measurement methods, variations in measurement of predictors and differences in populations studied. In the current study, we investigated the relationship between in-hospital mobility and a set of similar risk factors in functionally independent older adults (65+) hospitalized in acute care settings in Israel (N=206) and Denmark (N=113). In Israel, mobility was measured via ActiGraph and in Denmark by ActivPal for up to seven hospital days. Parallel analysis of covariance (ANCOVA) in each sample showed that community-mobility before hospitalization, mobility performance at admission and length of stay were associated with in-hospital mobility in both countries, whereas age and self-reported health status were associated with mobility only in Denmark. This comparison indicates that despite slightly different measurement approaches, similar risks are attributed to older adults’ low in-hospital mobility and emphasizes the contribution of commonly used pre-hospitalization mobility measures as strong and consistent risk factors. This knowledge can support a better understanding of the need of both standard risk assessments and country-based tailored approaches.
Correlates of Perceived Stress Among Community-Dwelling Older African Americans Without Dementia
Authors: Glover Crystal , Capuano Ana , Wilson Robert , Bennett David , Barnes Lisa 
Published: December 2021

Abstract
The purpose of this study was to identify correlates of perceived stress among older African Americans without dementia. We grouped correlates into four levels – environmental, sociocultural, behavioral, and biological – guided by the National Institute on Aging’s (NIA) Health Disparities Research Framework. We performed a cross-sectional data analysis with the Minority Aging Research Study using ordinal logistic regression analyses. Participants were 722 African Americans without dementia [mean age = 73.61 years (SD=6.33)]. Correlates from environmental (e.g., larger life space), sociocultural (e.g., larger social network size), behavioral (e.g., more purpose in life), and biological (e.g., higher global cognition) levels were associated with lower odds of having greater levels of perceived stress. Perceived stress was associated with correlates from every level. Future research is needed to examine how changes in these correlates may be related to perceived stress in older African Americans.
Living With COVID-19: Descriptions of African American Custodial Grandparents Mental Health Stress and Social Support Networks: A Pilot Study
Authors: Whitley Deborah , Kelley Susan 
Published: December 2021

Abstract
Research suggests custodial grandparents (CG) with chronic health conditions, limited economic resources, and restricted social connections are at risk for adverse mental health outcomes. The growing uncertainty surrounding COVID-19 seems to accentuate these findings. This paper presents preliminary descriptions of mental stress by a small sample of CG (n=26) surveyed after the onset of COVID-19. They described the social groups comprising their networks, and the methods used to engage with them. A majority of the sample (96.2%) reported experiencing mental stress since the onset of the virus; based on Brief Symptom Inventory results, five CG scored in the clinical range for stress. Food access, fear of getting sick, and grandchildren’s school requirements are leading sources of stress. Despite such challenges, CG report varying levels of social engagement with their support networks. The reported descriptions give preliminary insight how CG can maximize their social networks to build/sustain positive mental health well-being.
Measurement for Something as Personal as Dressing is Not Personalized
Authors: Prizer Lindsay , Zimmerman Sheryl 
Published: December 2021

Abstract
In 2018, the Alzheimer’s Association set forth Dementia Care Practice Recommendations in nine domains, one being support for activities for daily living (e.g., dressing, toileting, eating/nutrition). For example, preservation of dressing independence is important for dignity, autonomy, and to decrease caregiver burden. Measurement is necessary to guide care and assess outcomes related to dressing, but availability of related measures to assess processes, structures, and outcomes of care has not been examined; more so, the extent to which the related measures are person-centered is completely unexplored territory. This session will present a critical assessment of available measures grounded in the Donabedian Model. Of 21 identified measures, 4 assessed dressing alone, 16 included dressing as part of a larger scale, and 1 included dressing as a part of a scale to screen for dementia; none were person-centered. This session will suggest modifications to and need for new measures for person-centered dressing.
Testing a Preference Tool in Different Care Settings in Germany: Descriptive Results
Authors: Bergmann Johannes , Stacke Tobias , Rommerskirch-Manietta Mike , Purwins Daniel , Manietta Christina , Stroebel Armin , Roes Martina 
Published: December 2021

Abstract
Background: The tool “Preferences for Everyday Living Inventory” (PELI) for Nursing Homes (NH) was developed in the USA. In our project PELI-D, the PELI was translated from English into German and piloted in three care settings: Nursing Home (NH), Home Care (HC) and Adult Day Care (AD). Objective: The objective is to provide insights in preferences of importance of older adults in need of care in Germany. Methods: Data collection was carried out in 2019 on multiple measurement points: n=48 baseline (T0) and n=41 two-week follow-up (T1). Results: The results indicate that the importance of certain preferences distinguishes between the care settings: In NH preferences for body care and aspects of professional care are important. Additionally, in HC the aspects of social contact and eating/drinking are perceived as important. Comparing T0 and T1, importance of the item’s daily routines, social contact and aspects of privacy seem to be reliable.
Delivering Person-Centered Care During a Pandemic: Stakeholder Perspectives
Authors: Abbott Katherine , Corazzini Kirsten 
Published: December 2021

Abstract
Person-centered care (PCC) is an approach to care that both nursing homes (NH) and assisted living (AL) communities strive to provide. PCC is a philosophy that recognizes knowing the person and honoring individual preferences. However, when COVID-19 emerged, the NH and AL environments were ground zero for infection spread and disproportionate numbers of deaths among residents. As a result, many practices changed dramatically in efforts to reduce the transmission of COVID-19 in these communities. The purpose of this symposium is to discuss several projects that can speak to the impact of the pandemic on stakeholder efforts to provide PCC. First, Dr. Roberts presents feedback from residents and family members on the challenges COVID-19 created for family involvement in care conferences. In the second study, Dr. Behrens examines focus group data from direct-care nurses on their perceptions of delivering PCC related to risk of harm to staff and residents. The third study presents the voices of activities professionals who were implementing a PCC quality improvement project to communicate resident preferences, which illustrates both the importance of PCC during the pandemic, but also the challenges implementing during the pandemic. Fourth, the Kansas PEAK 2.0 program used provider feedback to direct and inform program responses through components such as consistent staffing. Finally, Dr. Zimmerman presents qualitative data from over 100 AL administrators, medical, and mental health care providers on their experiences pivoting during COVID-19. Our discussant will explore the implications of these studies in terms of the future of PCC in residential settings.
Nursing Staff Perceptions of Risk Outcomes in Delivering Preference-Based Person-Centered Care
Authors: Behrens Liza , Boltz Marie , Kolanowski Ann , Sciegaj Mark , Abbott Katherine , Madrigal Caroline , Van Haitsma Kimberly 
Published: December 2021

Abstract
Effective management of the perceived risks associated with delivering preference-based person-centered care (PBPCC) is historically challenging for nursing home staff. Existing research lacks the granularity needed to guide clinicians who fear negative health and safety outcomes for residents. This study examined direct-care nursing staff perceptions of outcomes associated with delivering PBPCC. Participants (N=27) worked in NHs experiencing 6-12 health citations, were mostly female (85%), and represented diverse ages, race, education, and collective work experience in NHs. Content analysis of verbatim transcripts from 12 focus groups identified an overarching theme of: “person-centered outcomes related to risk engagement”; and sub-themes of: harms to staff (e.g. fear, frustration, guilt); harms to residents (e.g. negative moods and behaviors, physical discomfort); and positive shared outcomes (e.g. building nurse-resident relationships, positive care environment). Implications for risk management that improves quality of care and life outcomes in a post-COVID era will be discussed.
Binge Drinking and Heavy Drinking Among Older Military Veterans: Applying the Theory of Intersectionality
Authors: Suntai Zainab , McDaniel Justin , Albright David , Wallace Julianne 
Published: December 2021

Abstract
The post-service impact of military experiences include post-traumatic stress disorder, depression, substance misuse and several other adverse outcomes that persist well into older adulthood. As such, older military veterans are at risk of developing alcohol dependency and those with existing stressors from other identities are at the highest risk of engaging in binge drinking or heavy drinking. This study used the theory of intersectionality to examine alcohol misuse by veteran status and age, veteran status and race and veteran status and sex. Data were derived from the 2016, 2017 and 2018 Brief Risk Factor Surveillance System (BRFSS) from the Centers for Disease Control and Prevention (CDC). The BRFSS is an annual survey conducted over the phone in all 50 states and territories. Survey-weighted logistic regression models were used to examine alcohol misuse among adults aged 65+ by veteran status and the intersection between age, race, and sex. Results showed no interaction between veteran status and age, and no interaction between veteran status and sex. However, there was a significant interaction between veteran status and race, in that Black/Other race veterans were more likely to engage in both binge drinking and heavy drinking compared to White veterans, White nonveterans and nonveterans of the same race. Interventions geared towards this population should therefore engage culturally sensitive approaches that consider the historical and systemic factors that contribute to these disparities in rates of alcohol misuse among older military veterans.