bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Dual-reporter Platform for Screening Tumor-targeted Extracellular Vesicles
Authors: Kanada Masamitsu , Linenfelser Lauren , Cox Elyssa , Gilad Assaf A. 
Published: December 2021

AbstractExtracellular vesicle (EV)-mediated transfer of biomolecules plays an essential role in intercellular communication and may improve targeted drug delivery. In the past decade, various approaches to EV surface modification for targeting specific cells or tissues have been proposed, including genetic engineering of parental cells or postproduction EV engineering. However, due to technical limitations, targeting moieties of engineered EVs have not been thoroughly characterized. Here, we report the bioluminescence resonance energy transfer (BRET) EV reporter, PalmReNL-based dual-reporter platform for characterizing the cellular uptake of tumor homing peptide (THP)-engineered EVs, targeting PDL1, uPAR, or EGFR proteins expressed in MDA-MB-231 breast cancer cells, simultaneously by bioluminescence measurement and fluorescence microscopy. Bioluminescence analysis of cellular EV uptake revealed the highest binding efficiency of uPAR-targeted EVs, whereas PDL1-targeted EVs showed slower cellular uptake. EVs engineered with two known EGFR-binding peptides via lipid nanoprobes did not increase cellular uptake, indicating that designs of EGFR-binding peptide conjugation to the EV surface are critical for functional EV engineering. Fluorescence analysis of cellular EV uptake allowed us to track individual PalmReNL-EVs bearing THPs in recipient cells. These results demonstrate that the PalmReNL-based EV assay platform can be a foundation for high-throughput screening of tumor-targeted EVs.
Can return on investment in knowledge management initiatives in organizations be measured?
Authors: Nakash Maayan , Bouhnik Dan 
Published: December 2021

PurposeThis paper focuses on the meanings attributed to the measurement of return on investment (ROI) in knowledge management (KM) initiatives in knowledge-intensive organizations. At the heart of this exploratory research is the introduction of a unique coherent perspective of discipline experts regarding the ROI metric, as part of their perception of assessing effectiveness in this field.Design/methodology/approachThe research begins with in-depth semi-structured personal interviews and continues with focus groups, as part of a qualitative research paradigm. The data were analyzed using a thematic analysis method, based on the grounded theory approach.FindingsThe findings provide empirical evidence regarding the significant challenges associated with the objective assessment of KM performance, which is deeply rooted in numerical-financial values. Despite the high status of ROI in the business environment, the authors find that decision-makers surprisingly avoid evaluating ROI for the most important resource of the organization, notwithstanding the immeasurable hopes that depend on this performance measure and the expectation of establishing the profitability of investment in organizational KM.Originality/valueThe uniqueness of this research is the adoption of the skeptical-critical research approach. For the first time, the authors interrogate the suitability and relevance of the general model of the ROI metric as a means of proving the value and contribution of well-managed knowledge to organizations. The authors call for adoption of a new integrative perspective for evaluating effectiveness, which will reflect the holistic set of KM in organizations.
Construction sustainability of container-modular-housing in coastal regions towards resilient community
Authors: Haque Md. Obidul , Aman Jayedi , Mohammad Fahim 
Published: December 2021

PurposeThis paper addresses housing problems of coastal areas in Bangladesh and investigates container-modular-housing (CMH) as a potential sustainable solution that establishes a resilient community.Design/methodology/approachPrimary data highlight the underlying challenges of coastal-housing developed by monitoring the day-to-day operations of the community and conducting interviews with community members. Secondary data came from existing literature on coastal-housing rules and regulations, CMH and similar ideas. The study used a hypothetical CMH cluster design, with three primary objectives in mind: future settlement re-arrangement, economic sustainability and environmental sustainability. To achieve the objectives, the research used a comparative examination of the current constructed form and CMH, as well as a computer-aided simulation approach.FindingsPrimary findings encompass issues of a given coastal area, including surrounding site studies, sustainability and resiliency demands due to broad exposure to the natural calamities. Driving toward a “CMH” based home design has the ability to create strategies for a resilient and sustainable community development while taking three primary objectives into account.Research limitations/implicationsA pilot project is needed to analyze the socio-cultural impact and overall construction feasibility.Practical implicationsThis research could be implemented to transform an informal construction system into a technical, resilient, sustainable architectural and engineering solution to build resilient communities.Originality/valueNumerous research projects have focused on the environmental sustainability of CMH. However, this study focuses on construction sustainability considering three major aspects which are yet to be addressed.
“Now I can see”: creative women fight against machismo in Chilean advertising
Authors: Mensa Marta , Grow Jean M. 
Published: December 2021

Purpose
This study aims to explore sexist codes in the creative departments of Chilean advertising agencies, where women represent only 4.7% of all creatives.

Design/methodology/approach
This study provides new insights into the experiences of women in advertising through 18 in-depth interviews with Chilean creative women.

Findings
The results show that gender discrimination begins in universities, where male professors are often the same people who hire creative talent into the advertising agencies and prefer men, which continues throughout women’s careers.

Originality/value
While there are numerous studies of advertising creative women in North American and European agencies, there are few on creative women in South American and virtually none on creative women in Chilean agencies.
An operational conceptualization of human resource analytics: implications for in human resource development
Authors: Jiang Yeling , Akdere Mesut 
Published: December 2021

Purpose
The purpose of this paper is to examine the evolution of the concept of human resource analytics (HRA) and propose an operational framework demonstrating the sources generating data for HRA, as well as the impact of HRA on multiple levels in the organization.

Design/methodology/approach
A review of literature was conducted to present the existing body of knowledge and build upon for the development of an operational framework for successful implementation of HRA as a human resources (HR) process.

Findings
Building upon the existing literature, this paper presents an operational HRA framework, positioning HRA as an analytical process through integrating advanced statistical methodology. HRA presents a tool to obtain evidence-based analytical results for improving people-related performance, operational effectiveness, and ultimately the impact of the business strategy. By using HR big data, HRA impacts multiple organizational levels, from individual employees to HR functions and the organizational strategy.

Practical implications
While research on data analytics has recently flourished across various management fields, this has not been the case for the broader field of HR. This is especially a growing concern as the lack of understanding of the basics and fundamentals of people analytics in the field of HR may delay the effective implementation and operationalization of HRA and present additional barriers impacting on-going HR activities, as well as HR’s role as a strategic business partner. HR practice may greatly benefit from gaining an understanding of HRA and the multi-levels of impact it may have on the organization.

Originality/value
This paper explores various concepts related to HRA by examining terms such as “HR metrics” vs “HR” and “HR big data” vs “big data.” Furthermore, the comprehensive HRA operational framework presented in this paper provides HR professionals and researchers with a better understanding of HRA in the age of data analytics and artificial intelligence.
Impact of Sarbanes Oxley Act on initial public offerings: new evidence from reverse leveraged buyouts
Authors: Reddy Nischala P. , Le Ben , Paul Donna L. 
Published: December 2021

PurposeThis paper aims to investigate how the passage of the Sarbanes Oxley Act (SOX) impacted the likelihood and timing of the decision of leveraged buyout (LBO) firms to exit via initial public offering (IPO) (reverse-LBO) and the mediating effect of reputed private equity (PE) firms.Design/methodology/approachThe sample comprises firms that went private via LBO between 1990 and 2018. The authors use logistic and ordinary least square regression models to compare the effect of SOX on the re-listing decision and the time taken to re-list.FindingsLBO firms were less likely to exit via public offering after SOX, and the time from LBO to IPO was significantly longer for exiting firms post-SOX. PE firm reputation partially reversed the reluctance to exit via IPO and shortened the time to exit.Research limitations/implicationsThe primary focus is RLBOs; the authors do not directly examine other methods of LBO exit. The findings have policy implications for unintended impacts of SOX. Despite the benefits of increasing transparency and protecting investors, SOX reduced the likelihood of going public and increased the time to IPO, potentially reducing product market competition.Originality/valueRLBOs present a unique experimental setting as the authors can test the impact of SOX on both the likelihood and time to go public, whereas prior literature using first-time IPO samples are able to test only the likelihood. The authors also show that the reputation of the advising PE firm attenuates the reluctance and time taken for RLBOs to re-list. The authors are, thus, able to provide a new perspective on the impact of SOX on the going public decision.
Drifting the goals archetype: a systemic study
Authors: Bagodi Virupaxi , Mahanty Biswajit 
Published: December 2021

PurposeManagerial decision-making is an area of interest to both academia and practitioners. Researchers found that managers often fail to manage complex decision-making tasks and system thinkers assert that generic structures known as systems archetypes help them to a great deal in handling such situations. In this paper, it is demonstrated that decision makers resort to lowering of goal (quick-fix) in order to resolve the gap between the goal and current reality in the “drifting the goals” systems archetype.Design/methodology/approachA real-life case study is taken up to highlight the pitfalls of “drifting the goals” systems archetype for a decision situation in the Indian two-wheeler industry. System dynamics modeling is made use of to obtain the results.FindingsThe decision makers fail to realize the pitfall of lowering the goal to resolve the gap between the goal and current reality. It is seen that, irrespective of current less-than-desirable performance, managers adopting corrective actions other than lowering of goals perform better in the long run. Further, it is demonstrated that extending the boundary and experimentation results in designing a better service system and setting benchmarks.Practical implicationsThe best possible way to avoid the pitfall is to hold the vision and not lower the long term goal. The managers must be aware of the pitfalls beforehand.Originality/valueSystems thinking is important in complex decision-making tasks. Managers need to embrace long-term perspective in decision-making. This paper demonstrates the value of systems thinking in terms of a case study on the “drifting the goals” systems archetype.
Study on the quality improvement on black land in Northeast China under the environment of sustainable agricultural development
Authors: Teng Yun , Pang Boyuan , Guo Xiangyu 
Published: December 2021

PurposeThe authors are committed to providing the Chinese government with a foundation for making decisions that will protect black land and ensure long-term agricultural development.Design/methodology/approachUsing the grounded theory approach, this study investigates the influencing factors affecting the quality of black land in Northeast China and proposes a hypothetical model for the mechanism of the influencing factors on the quality of black land in Northeast China.FindingsThe factors influencing the quality of black land include not only soil quality, ecological quality and environmental quality, but also economic quality and management quality, and can be classified into five categories. There are complex influence relationships between various factors and black land quality, with soil quality, ecological quality, environmental quality and management quality having a positive influence on economic quality. Soil quality, ecological quality and environmental quality are all improved as a result of good management. Black land quality is influenced positively by environmental quality, economic quality and management quality.Research limitations/implicationsThe quality of black land is a major concern in terms of food production and long-term agricultural development. The black land in Northeast China was chosen as the subject of this study, and the research findings have some limitations. The next step will be to expand from studying the black land in Northeast China to the black land worldwide.Originality/valueIn Northeast China, the quality of the five dimensions of black land must be improved in a coordinated and consistent manner.
The impact of entrepreneurs' full-time versus hybrid employment and social connections on new venture survival: a USA–India comparison
Authors: Zhang Xi , Gopalakrishnan Shanthi , Roy Raja , Bandera Cesar 
Published: December 2021

PurposeThe purpose of this paper is to explore how the entrepreneurs' social connections and types of employment differentially affect the survival of startup firms in the USA and India. Further, the authors analyze the differences during both the early stage and the later stages of new ventures.Design/methodology/approachThe authors use data from the Global Entrepreneurship Monitor (GEM) database between 2012 and 2014 and examine the hypothesized effects with logistic regression analyses.FindingsThe analysis reveals that an entrepreneur's social connections with other entrepreneurs favor the survival of the focal entrepreneur's early-stage business in the USA. However, social connections are more critical for later-stage ventures in India. During the early stage, new ventures of full-time entrepreneurs are more likely to survive in India, whereas those by hybrid entrepreneurs are more likely to survive in the USA. The differences between the importance of full-time and hybrid entrepreneurs across geographies are less discernible during the later stages of new ventures.Originality/valueThe novelty of this paper is that it demonstrates the significant differences in the way social connections and types of employment (hybrid versus full-time) affect the survival of entrepreneurial firms in the early and later stages. The study also expands the international business literature by shedding new light on country-level differences that affect the survival of new ventures.
Work transitions after serious hand injury: Current occupational therapy practice in a middle‐income country
Authors: Buchanan Helen , van Niekerk Lana 
Published: December 2021

AbstractIntroductionWork‐related transitions following serious hand injury can be complex for people with hand injuries and rehabilitation professionals supporting the return‐to‐work process. This study explored South African occupational therapy practice related to work transitions after a serious hand injury.MethodsIn this collective case study, maximum variation sampling was used to select seven occupational therapists involved in facilitating work‐related transitions for people with serious hand injuries. Participants selected at least five cases that illustrated the breadth of their practice in terms of work transitions; these cases formed the focus of the semi‐structured interviews. Data were analysed using inductive content analysis. Exemplar quotations were extracted to support emergent key themes.ResultsThere was one overarching theme—Ongoing appraisal of the fit between function and inherent work demands—which comprised three stages: (1) determining and facilitating readiness to work; (2) managing the risk and trauma of returning to work, and (3) implementing reasonable accommodation. The central theme comprised six strategies that were used to optimise the transition process and achieve the best possible outcome.ConclusionThe study highlighted the importance of work‐related transitions that are context‐driven, flexible, and involve multiple stakeholders. The occupational therapists demonstrated how they drew on their knowledge of local contexts to solve problems and generate effective individual strategies over the rehabilitation period. The findings may be applicable to other low‐ or middle‐income countries where the return‐to‐work process may not be as predictable as high‐income countries.
Not all oil shocks on the trade balance are alike: Empirical evidence from South Korea
Authors: Baek Jungho 
Published: December 2021

AbstractThe primary interest in the present article lies in the contribution to the existing literature by investigating the impacts that three components of oil shocks—oil supply shocks, aggregate demand shocks and oil‐specific demand shocks—have on three measures of South Korea's trade balances—oil, non‐oil and total trade balances. We reveal that aggregate demand shocks have significant impacts, while oil supply and oil‐specific demand shocks have negligible impacts. Additionally, the overall impact of the three oil shocks on South Korea's trade balances appears to rely on the response of the non‐oil trade balance.
A survey of cognitive function in peritoneal dialysis patients
Authors: Wang Yan , Zhang Hong‐Xia , Wang Yong‐Chun , Song Shu‐Hua , Jin Xue‐Qin , Tian Na , Chen Meng‐Hua 
Published: December 2021

AbstractIntroductionThe aim of this study was to investigate how peritoneal dialysis and other influencing factors affect patients' cognitive function.MethodsThe 85 subjects in the study group were regular patients in our center. The control group included 88 age and gender matched healthy individuals who were with normal renal function. The study subjects' cognitive levels and related factors were analyzed using several screening instruments: the cognitive function was measured using the Montreal Cognitive Assessment Scale and statistical analysis was conducted based on the relevant data.ResultsThe results showed that cognitive impairment was higher in peritoneal dialysis patients than in non‐dialysis subjects. Age and educational background were single factors that affected cognitive function, which was more likely to be impaired at a higher age level and/or a lower educational level.ConclusionCognitive function can be impaired by peritoneal dialysis, and age and education levels are influencing factors.
The importance and impact of recognizing metabolic dysfunction‐associated fatty liver disease in patients with chronic hepatitis C
Authors: Al‐Omary Ahmed , Byth Karen , Weltman Martin , George Jacob , Eslam Mohammed 
Published: December 2021

ObjectivesMetabolic dysfunction‐associated fatty liver disease (MAFLD) can develop in any patient, including those with chronic hepatitis C (CHC). The recently proposed diagnostic criteria for MAFLD provide a unique opportunity to investigate the impact of concomitant fatty liver in patients with another established cause for their liver disease. The objective of our study was to assess the characteristics and outcomes of patients with a dual etiology liver disease.MethodsWe evaluated 1181 patients including 744 with CHC and 437 with MAFLD. All patients in both cohorts underwent liver biopsy indicating disease activity and fibrosis stage.ResultsNearly half (43.1%) the patients with CHC had concomitant MAFLD. Comparing patients with CHC alone with those with a dual etiology disease, we found that the latter had more severe liver injury, hepatic inflammation and fibrosis (all P < 0.001). Interestingly, lean or normal‐weight patients with CHC and MAFLD had a similar fibrosis stage compared to the two other subgroups of MAFLD (obesity and/or diabetes mellitus). There was no statistical significance in hepatic steatosis and fibrosis between genotype 3 CHC and MAFLD group compared to other genotypes.ConclusionsPatients with CHC and concomitant MAFLD had more severe liver disease than those with viral hepatitis alone. Recognizing coexisting MAFLD in patients with CHC is important for the delivery of holistic care.
2‐Methylhopanoids in geographically distinct, arid biological soil crusts are primarily cyanobacterial in origin
Authors: Garby Tamsyn J. , Jordan Matthew , Timms Verlaine , Walter Malcolm R. , Neilan Brett A. 
Published: December 2021

SummaryMicrobial palaeontology is largely reliant on the interpretation of geologically stable biomarkers or molecular fossils. Biomolecules that are both specific to particular groups of organisms and stable on a geological scale are invaluable for tracing the emergence and diversification of lifeforms, particularly in cases where mineral fossils are lacking. 2‐Methylhopanoids and their diagenic product, 2‐methylhopanes, are highly abundant bacterial membrane lipids, recoverable from samples in excess of a billion years old. In this work we used degenerate PCR, targeting 2‐methylhopanoid biosynthesis genes, and sequencing to show that the ability to produce these molecules in arid biological soil crusts from deserts in diverse geographical locations (Utah, USA, and the Pilbara, Australia) is largely confined to cyanobacteria. These data suggest that 2‐methylhopanes can be used as a proxy for cyanobacterial presence within these environments, contributing to our understanding of the emergence of terrestrial life on Earth.
Towards a Portfolio Approach: Partnerships for Sustainable Transformations
Authors: Horan David 
Published: December 2021

AbstractThis perspective article examines the role that partnerships can play in achieving the Sustainable Development Goals (SDGs). It elucidates a portfolio approach to partnerships that could align well with achieving a sustainable transformation. To conclude, it outlines recommendations on how this approach may be operationalized in research, policy, and practice. Much remains to be done on a portfolio approach. Practice and sharing of good practice should be guiding principles to facilitate peer‐to‐peer learning. It is also important to address power imbalances, conflicting interests, and limited representation in partnerships.