bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Anti-inflammatory Treatment with AMD3100 and CX3CR1 Deficiency on GABAA Receptor Subunit and Expression of Glutamate Decarboxylase Isoforms After Stroke
Authors: Michalettos Georgios , Walter Helene L. , Antunes Ana Rita Pombo , Wieloch Tadeusz , Talhada Daniela , Ruscher Karsten 
Published: August 2021

AbstractFollowing stroke, attenuation of detrimental inflammatory pathways might be a promising strategy to improve long-term outcome. In particular, cascades driven by pro-inflammatory chemokines interact with neurotransmitter systems such as the GABAergic system. This crosstalk might be of relevance for mechanisms of neuronal plasticity, however, detailed studies are lacking. The purpose of this study was to determine if treatment with 1,1′-[1,4-phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane] (AMD3100), an antagonist to the C-X-C chemokine receptor type 4 (CXCR4) and partial allosteric agonist to CXCR7 (AMD3100) alone or in combination with C-X3-C chemokine receptor type 1 (CX3CR1) deficiency, affect the expression of GABAA subunits and glutamate decarboxylase (GAD) isoforms. Heterozygous, CX3CR1-deficient mice and wild-type littermates were subjected to photothrombosis (PT). Treatment with AMD3100 (0.5 mg/kg twice daily i.p.) was administered starting from day 2 after induction of PT until day 14 after the insult. At this time point, GABAA receptor subunits (α3, β3, δ), GAD65 and GAD67, and CXCR4 were analyzed from the peri-infarct tissue and homotypic brain regions of the contralateral hemisphere by quantitative real-time PCR and Western Blot. Fourteen days after PT, CX3CR1 deficiency resulted in a significant decrease of the three GABAA receptor subunits in both the lesioned and the contralateral hemisphere compared to sham-operated mice. Treatment with AMD3100 promoted the down-regulation of GABAA subunits and GAD67 in the ipsilateral peri-infarct area, while the β3 subunit and the GAD isoforms were up-regulated in homotypic regions of the contralateral cortex. Changes in GABAA receptor subunits and GABA synthesis suggest that the CXCR4/7 and CX3CR1 signaling pathways are involved in the regulation of GABAergic neurotransmission in the post-ischemic brain.
Sozialpädagogisches Wissen vermitteln
Authors: Engelbracht Mischa 
Published: August 2021

ZusammenfassungWenn über die Vermittlung sozialpädagogischen Wissens nachgedacht wird, stellt insbesondere die Breite des Feldes der sozialpädagogischen Qualifikationsangebote eine besondere Herausforderung dar. Neben verschiedenen Orten finden sich unterschiedliche Niveaustufen der Qualifikation. Ein Ort sind dabei die Fachschulen für Sozialpädagogik, an denen auf dem Niveau der Kinderpfleger_innen/Sozialassistent_innen (DQR 4) und Erzieher_innen (DQR 6) ausgebildet wird. Dem Prinzip der doppelten Vermittlungspraxis folgend, gilt es für Überlegungen zur Sozialpädagogik und ihrer Didaktik entsprechend die Orte, Qualifikationsstufen und auch den Transfer des Wissens zwischen den Orten und Niveaustufen zu berücksichtigen.
Consciousness and Intentionality in Franz Brentano
Authors: Antonelli Mauro 
Published: August 2021

AbstractThe paper argues against the growing tendency to interpret Brentano’s conception of inner consciousness in self-representational terms. This trend has received support from the tendency to see Brentano as a forerunner of contemporary same-order theories of consciousness and from the view that Brentano models intransitive consciousness on transitive consciousness, such that a mental state is conscious insofar as it is aware of itselfas an object. However, this reading fails to take into account the Brentanian concept of object, which is ultimately derived from ancient and medieval philosophy, as well as the secondary, elusive character that Brentano attributes to inner perception. According to Brentano, we have an aspectual but transparent consciousness of transcendent objects, whereas our awareness of our own mental acts is always complete but incidental, and ultimately opaque. Reversing the relationship between intentionality and consciousness faces difficulties at the textual interpretative level, but also raises theoretical problems, for it risks treating Brentano’s theory of mind as a form of subjectivism and idealism.
From virtual to real healing: a critical overview of the therapeutic use of virtual reality to cope with mourning
Authors: Pizzoli Silvia Francesca Maria , Monzani Dario , Vergani Laura , Sanchini Virginia , Mazzocco Ketti 
Published: August 2021

AbstractIn recent years, virtual reality (VR) has been effectively employed in several settings, ranging from health care needs to leisure and gaming activities. A new application of virtual stimuli appeared in social media: in the documentary ‘I met you’ from the South-Korean Munhwa Broadcasting, a mother made the experience of interacting with the avatar of the seven-year-old daughter, who died four years before. We think that this new application of virtual stimuli should open a debate on its possible implications: it represents contents related to grief, a dramatic and yet natural experience, that can have deep psychological impacts on fragile subjects put in virtual environments. In the present work, possible side-effects, as well as hypothetical therapeutical application of VR for the treatment of mourning, are discussed.
Emotional intelligence in Greek teacher education: Findings from a short intervention
Authors: Kyriazopoulou  , Pappa Sotiria 
Published: August 2021

AbstractEmotional intelligence (EI) is widely known to be crucial for professional development in education, and it is a curricular component of Greek teacher education. Still, there is little information available on student teachers’ EI. The aim of this study was to explore whether student teachers’ trait EI can be developed through a two-week, EI-focused intervention. The study followed a quasi-experimental design with a mixed method approach, using the Trait Emotional Intelligence Questionnaire-Short Form (Greek version) (N = 42) and reflective emotion diaries (N = 19). The participants were third-year undergraduate students studying primary education and teaching at the University of Crete. While the results from the statistical analysis showed no development of student teachers’ trait EI, the findings from the thematic analysis of the reflective emotion diaries suggested that this intervention was beneficial, facilitating emotion identification and potentially enabling emotion regulation through increased self-awareness. The study concludes with a discussion of its limitations and practical implications for future intervention studies on EI.
Rare lung cancers—Primary pulmonary leiomyosarcoma: A case report
Authors: Nagl Laurenz , Seeber Andreas , Widmann Gerlig , Schmitz Katja , Maier Herbert , Pall Georg , Wolf Dominik , Pircher Andreas 
Published: August 2021

SummaryPrimary pulmonary sarcomas (PPS) are rare mesenchymal lung cancers, which do not present clinically or radiological different to lung carcinomas. Definite PPS diagnosis can only be made by histological analysis and detailed staging examinations in order to exclude a secondary pulmonary malignancy such as metastatic soft tissue sarcoma or another solid tumour. Here we present the case of a 66-year-old woman with a pulmonary mass infiltrating the diaphragm and the mediastinal adipose tissue, which was identified as leiomyosarcoma. The patient received curative surgery with complete tumour R0 resection. The prognosis of PPS is defined by tumour size, lymph node status and histological grading. Surgery is the mainstay of therapy and there is no definitive indication for adjuvant therapy for R0-resected and lymph-node-negative patients like in our case. However, multimodal therapy approaches such as (neo)adjuvant chemo- and radiotherapy can contribute to improving locoregional tumour control, which is the most important prognostic factor. With our case report we want to raise awareness for pulmonary sarcomas as a relevant proportion of rare lung cancers which have to be kept in mind during the differential diagnosis. Moreover, we aim to discuss the complex and individual interdisciplinary management.
Update Ichthyosen
Authors: Schmuth M. 
Published: August 2021

ZusammenfassungIchthyosen sind generalisierte Verhornungsstörungen, die sich durch sichtbare Schuppung und/oder Hyperkeratosen der Haut manifestieren. Der klinische Ausprägungsgrad und die Ätiologie sind heterogen. Zahlreiche verschiedene Mutationen in Genen mit Bedeutung für die Keratinozytendifferenzierung und epidermale Barrierefunktion wurden beschrieben. Für die klinische Differenzialdiagnose ist das Leitsymptom der generalisierten Schuppung herausfordernd. Die vorliegende Übersichtsarbeit beschreibt die wichtigsten differenzialdiagnostischen Kriterien und therapeutischen Möglichkeiten.
Transcatheter tricuspid valve repair: early experience in the Netherlands
Authors: Meijerink F. , Koch K. T. , de Winter R. J. , Holierook M. , Rensing B. J. W. M. , Timmers L. , Eefting F. D. , Swaans M. J. , Bouma B. J. , Baan J. 
Published: August 2021

Abstract
Background
Symptomatic tricuspid regurgitation (TR) is increasingly prevalent and impairs quality of life and survival, despite medical treatment. Transcatheter tricuspid valve repair (TTVR) has recently become available as a treatment option for patients not eligible for tricuspid valve surgery. In this study we describe the early experience with TTVR in the Netherlands.

Methods
All consecutive patients scheduled for TTVR in two tertiary hospitals were included in the current study. Patients were symptomatic and had severe functional TR. TTVR was performed either with the MitraClip (off-label use) or dedicated TriClip delivery system and device. Procedural success was defined as achievement of clip implantation, TR reduction ≥ 1 grade and no need for re-do surgical or transcatheter intervention. Clinical improvement was evaluated after 4 weeks.

Results
Twenty-one patients (median age 78 years, 33% male, 95% New York Heart Association class ≥ 3, 100% history of atrial fibrillation) underwent TTVR. Procedural success was achieved in 16 patients, of whom 15 reported symptomatic improvement (New York Heart Association class 1 or 2). There was no in-hospital mortality and no major complications occurred. Baseline glomerular filtration rate and TR coaptation gap size were associated with procedural success.

Conclusion
The current study showed that TTVR seems a promising treatment option for patients with severe functional TR deemed high risk for surgery. Successful TR reduction is most likely in patients with limited coaptation gap size and strongly determines clinical benefit. Adequate patient selection and timing of treatment seem essential for an optimal patient outcome.
Low SARS-CoV-2 seroprevalence but high perception of risk among healthcare workers at children’s hospital before second pandemic wave in Germany
Authors: Neumann Marietta , Aigner Annette , Rossow Eileen , Schwarz David , Marschallek Maria , Steinmann Jörg , Stücker Ralf , Koenigs Ingo , Stock Philippe 
Published: August 2021

Abstract
Background
Healthcare workers are considered a particularly high-risk group during the coronavirus disease 2019 (COVID-19) pandemic. Healthcare workers in paediatrics are a unique subgroup: they come into frequent contact with children, who often experience few or no symptoms when infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and, therefore, may transmit the disease to unprotected staff. In Germany, no studies exist evaluating the risk of COVID-19 to healthcare workers in paediatric institutions.

Methods
We tested the staff at a large children’s hospital in Germany for immunoglobulin (Ig) G antibodies against the nucleocapsid protein of SARS-CoV-2 in a period between the first and second epidemic wave in Germany. We used a questionnaire to assess each individual’s exposure risk and his/her own perception of having already been infected with SARS-CoV-2.

Results
We recruited 619 participants from all sectors, clinical and non-clinical, constituting 70% of the entire staff. The seroprevalence of SARS-CoV-2 antibodies was 0.325% (95% confidence interval 0.039–1.168). Self-perceived risk of a previous SARS-CoV-2 infection decreased with age (odds ratio, 0.81; 95% confidence interval, 0.70–0.93). Having experienced symptoms more than doubled the odds of a high self-perceived risk (odds ratio, 2.18; 95% confidence interval, 1.59–3.00). There was no significant difference in self-perceived risk between men and women.

Conclusions
Seroprevalence was low among healthcare workers at a large children’s hospital in Germany before the second epidemic wave, and it was far from a level that confers herd immunity. Self-perceived risk of infection is often overestimated.
Prey preferences, consumption rates and predation effects of Asian shore crabs (Hemigrapsus takanoi) in comparison to native shore crabs (Carcinus maenas) in northwestern Europe
Authors: Cornelius Annika , Wagner Katerina , Buschbaum Christian 
Published: August 2021

AbstractThe Asian brush-clawed shore crabHemigrapsus takanoiwas introduced to the northern Wadden Sea (southeastern North Sea) in 2009 and now represents one of the most abundant brachyuran crab species. Abundance studies revealed an increase of mean crab densities on mixed reefs of native blue mussels (Mytilus edulis) and Pacific oysters (Magallana gigas) from 18 individuals m−2in 2011 to 216 individuals m−2in 2020. Despite its current high densities only little is known about the feeding habits ofH. takanoi, its effects on prey populations and on the associated community in the newly invaded habitat. We summarize results of individual field and laboratory experiments that were conducted to assess feeding habits and consumption effects caused by Asian brush-clawed shore crabs and, additionally, compare the feeding ecology ofH. takanoiwith the one of the native shore crabCarcinus maenas. Field experiments manipulating crab densities revealed that both crab species affected the recruitment success of blue mussels, Pacific oysters and Australian barnacles (Austrominius modestus) with highest number of recruits at crab exclusion. However, endobenthic polychaetes within the reefs were differently affected. Only the nativeC. maenascaused a significant reduction in polychaete densities, whereas the introducedH. takanoihad no effect. Additional comparative laboratory studies revealed that singleC. maenasconsume more juvenile blue mussels than Asian brush-clawed shore crabs of the same size class. When offering amphipods as a mobile prey species, we found the same pattern with higher consumption rates byC. maenasthan byH. takanoi.For Asian but not for native shore crabs, we detected a sex-dependent feeding behavior with maleH. takanoipreferring blue mussels, while females consumed more amphipods. Considering mean crab densities and feeding behavior, our results suggest that despite lower consumption rates of single crabs, Asian brush-clawed shore crabs can cause stronger impacts on prey organisms than the nativeC. maenas,becauseH. takanoiexceeds their densities manifold. A strong impact of the invader on prey populations is supported by low amphipod occurrence at sites whereH. takanoidensity is high in the study area. Thus, the introduced Asian brush-clawed shore crab is an additional consumer with significant effects on the associated community of mixed reefs of mussels and oysters in the Wadden Sea.
Continuing the sequence? Towards an economic evaluation of whole genome sequencing for the diagnosis of rare diseases in Scotland
Authors: Abbott Michael , McKenzie Lynda , Moran Blanca Viridiana Guizar , Heidenreich Sebastian , Hernández Rodolfo , Hocking-Mennie Lynne , Clark Caroline , Gomes Joana , Lampe Anne , Baty David , McGowan Ruth , Miedzybrodzka Zosia , Ryan Mandy 
Published: August 2021

AbstractNovel developments in genomic medicine may reduce the length of the diagnostic odyssey for patients with rare diseases. Health providers must thus decide whether to offer genome sequencing for the diagnosis of rare conditions in a routine clinical setting. We estimated the costs of singleton standard genetic testing and trio-based whole genome sequencing (WGS), in the context of the Scottish Genomes Partnership (SGP) study. We also explored what users value about genomic sequencing. Insights from the costing and value assessments will inform a subsequent economic evaluation of genomic medicine in Scotland. An average cost of £1,841 per singleton was estimated for the standard genetic testing pathway, with significant variability between phenotypes. WGS cost £6625 per family trio, but this estimate reflects the use of WGS during the SGP project and large cost savings may be realised if sequencing was scaled up. Patients and families valued (i) the chance of receiving a diagnosis (and the peace of mind and closure that brings); (ii) the information provided by WGS (including implications for family planning and secondary findings); and (iii) contributions to future research. Our costings will be updated to address limitations of the current study for incorporation in budget impact modelling and cost-effectiveness analysis (cost per diagnostic yield). Our insights into the benefits of WGS will guide the development of a discrete choice experiment valuation study. This will inform a user-perspective cost–benefit analysis of genome-wide sequencing, accounting for the broader non-health outcomes. Taken together, our research will inform the long-term strategic development of NHS Scotland clinical genetics testing services, and will be of benefit to others seeking to undertake similar evaluations in different contexts.
“That’s kind of like the big struggle right now is can we get PrEP?”: Facilitators and Barriers to PrEP Uptake Among Active Duty Gay and Bisexual Men
Authors: Beltran Raiza M. , Schuyler Ashley C. , Blair Cherie S. , Goldbach Jeremy T. , Castro Carl A. , Holloway Ian W. 
Published: August 2021

Abstract
Introduction
The US Military is experiencing a rise in HIV infections among gay and bisexual men (GBM) serving on active duty, yet little is known about this population’s uptake of pre-exposure prophylaxis (PrEP), an evidence-based intervention for HIV prevention. This mixed methods study examines the facilitators and barriers to PrEP access and uptake among active duty GBM.

Methods
Active duty GBM were recruited using respondent-driven sampling (2017 and 2018). Participants (n = 93) answered quantitative survey questions on PrEP interest and accessibility. Another set of participants (n = 10) discussed their PrEP experiences in qualitative interviews. We conducted descriptive and bivariate analyses of quantitative data, while qualitative data were analyzed using structural and descriptive coding techniques.

Results
Approximately 71% of active duty GBM indicated interest in accessing PrEP. A greater proportion of those who disclosed (vs. did not disclose) their sexual orientation to their military doctor discussed (p < 0.001) or accessed (p = 0.017) PrEP. The following qualitative themes emerged: (1) providers’ negative views and knowledge gaps related to PrEP; (2) lack of a systems approach to PrEP access; (3) confidentiality concerns; and (4) reliance on peer networks for PrEP guidance and support.

Conclusions
Study results indicate that active duty GBM are interested in and want to discuss PrEP with their military doctors, but gaps in providers’ PrEP-related knowledge and skills, as well as mistrust in the military health care system, remain.

Policy Implications
A system-wide approach that addresses confidentiality concerns and removes procedural barriers to PrEP access is recommended to improve PrEP uptake in this population.
Sexual Behavior Change Among Gay and Bisexual Men During the First COVID-19 Pandemic Wave in the United States
Authors: McKay Tara , Henne Jeff , Gonzales Gilbert , Gavulic Kyle A. , Quarles Rebecca , Gallegos Sergio Garcia 
Published: August 2021

Abstract
Background
After decades of navigating HIV and other sexually transmitted infections, gay and bisexual men are responding to new and uncertain risks presented by the coronavirus (COVID-19) pandemic by adapting their sexual behavior.

Methods
This paper uses data from a national sample of 728 gay and bisexual men collected from April 10 to May 10, 2020, to examine changes to sexual behavior in response to the first wave of the pandemic in the USA. We also assess whether behavior modifications are associated with exposure to statewide public health measures, including Stay-at-Home orders.

Results
Sexual minority men report significant changes to their sexual behavior and partner selection during the first wave. Nine out of 10 men reported having either one sexual partner or no sexual partner in the last 30 days at the time of interview, a decrease compared to just before the pandemic for nearly half of men surveyed. Reporting no sexual partners in the last 30 days was significantly predicted by increased exposure to a Stay-at-Home order. Sexual minority men also reduced interactions with casual partners, increased no-contact sexual behaviors (e.g., masturbation and virtual sex), and engaged in new strategies to reduce their risks of infection from partners. HIV-positive men were particularly likely to adopt strategies including avoiding casual partners and avoiding public transportation to meet sexual partners.

Conclusion
Sexual minority men’s behavior changes during the first wave may have reduced the impact of the coronavirus pandemic on their communities. Despite substantial changes in sexual behavior for most men in our sample during the initial first wave, we identify some concerns around the sustainability of certain behavioral changes over time and nondisclosure of COVID-19 symptoms to partners.
Modeling and control of a hexacopter with a passive manipulator for aerial manipulation
Authors: Guo Pin , Xu Kun , Deng Huichao , Liu Haoyuan , Ding Xilun 
Published: August 2021

AbstractIn this paper, a multi-propeller aerial robot with a passive manipulator for aerial manipulation is presented. In order to deal with the collision, external disturbance, changing inertia, and underactuated characteristic during the aerial manipulation, an adaptive trajectory linearization control (ATLC) scheme is presented to stabilize the multi-propeller aerial robot during the whole process. The ATLC controller is developed based on trajectory linearization control (TLC) method and model reference adaptive control (MRAC) method. The stability of the proposed system is analyzed by common Lyapunov function. Numerical simulations are carried out to compare the ATLC with TLC controller facing collision, external disturbance and changing inertia during an aerial manipulation. Experimental results prove that the developed robot can achieve aerial manipulation in the outdoor environment.
Offene Bildungsmaterialien als Wegbereiter zu einer Kultur des Teilens in der Erwachsenen- und Weiterbildung – Befunde aus Sicht der Lehrenden
Authors: Schöb Sabine , Biel Carmen , Kilian Lars 
Published: August 2021

ZusammenfassungDer Beitrag thematisiert Herausforderungen bei der Etablierung einer Community von Lehrenden der Erwachsenen- und Weiterbildung, die durch den freien und inkludierenden Austausch von Offenen Bildungsmaterialien (Open Educational Resources, OER) geprägt ist. Aus der Sicht der Lehrenden wird betrachtet, welche Bedeutung vorhandene Kompetenzen, persönliche Einstellungen und soziale Werthaltungen Lehrender für den Umgang mit OER haben und welche Rahmenbedingungen für einen aktiven und kollaborativen Umgang im Sinne einer Open Culture förderlich sind. Die über eine quantitative Befragung gewonnenen Aussagen werden mit einer Auswertung der Nutzung von Informations- und Lernangeboten zum sachgerechten Umgang mit OER am Beispiel des Portals wb-web gerahmt. Die Ergebnisse zeigen vor allem den Bedarf, rechtliche Sicherheit und Infrastrukturen zu schaffen, um das Erstellen, Teilen und Nachnutzen von qualitativ hochwertigen und bedarfsgerecht einsetzbaren OER zu ermöglichen.