bluuebunny/crossref_metadata_2025_split huggingface dataset:
Key residue Unlocks Dual PIP2-Dependent and Independent Gating in G Protein-Gated Inwardly Rectifying Potassium Channels
Authors: Nguyen Ha , Mount Jonathan , Hutchinson Keino , Zhao Yihan , Zhao Yulin , Glaaser Ian W , Yuan Peng , Schlessinger Avner , Slesinger Paul A 
Published: February 2025

AbstractG protein-gated inwardly rectifying potassium (GIRK) channels mediate membrane hyperpolarization in response to G protein-coupled receptor activation and are critical for regulating neuronal excitability. The membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) is essential for regulating a large family of ion channels, and disruptions in PIP2interactions contribute to some neurological diseases. Structural analyses have identified key residues in PIP2-mediated gating of the GIRK2 channel. Notably, Arginine-92 (R92), a highly conserved basic residue at the membrane interface in GIRK2, interacts with PIP2as well as cholesteryl hemisuccinate (CHS), a potentiator of GIRK2. Here, we used a combination of electrophysiological assays, fluorescent K+flux measurements, cryo-electron microscopy, and molecular dynamics simulations, and find that mutations at R92 (Y, F, and Q) not only alter PIP2sensitivity but can also reveal a novel gating mechanism that is independent of PIP2. These findings indicate that R92 plays a crucial role in modulating GIRK2 channel gating, offering new insights into developing potential therapeutic targets for treating neurological disorders linked to GIRK channel dysfunction.
A Physiologically-based Model of Localized Mucociliary Clearance in the Airways
Authors: Shapiro Monica E. , Corcoran Timothy E. , Bertrand Carol A. , Parker Robert S. 
Published: February 2025

AbstractThe mucociliary clearance (MC) system clears mucus, pathogens, and toxins from the airways. Whole lung MC rate can be measured using gamma camera imaging after the inhalation of radiolabeled particulate. We sought a means to evaluate the therapeutic effect of clearance enhancing therapies in different airway size groups. We developed a mathematical model of mucus transport in the lung that, when informed by imaging data, estimates MC rate and unclearable activity at points across the airway tree. We fit the model to imaging studies from 11 healthy controls (HC), resulting in a per-point mean absolute error (MAE) of 0.085 ± 0.016% of the total particulate deposition. Using principal component analysis and hierarchical clustering, we reduced the number of fitted clearance rate coefficients from 114 to 5 with only an 8.7% increase in MAE. These 5 cluster groups were closely associated with specific regions of the lung and likely with specific airway size groups. Comparing the HC group to a cystic fibrosis (CF) group we found only one cluster with significantly depressed MC rates in CF corresponding to the lower lobe. The inhalation of 7% hypertonic saline (HS) by the CF group increased MC rate in all clusters and decreased unclearable activity in 4/5 clusters. The computational model described provides detailed regional estimates of MC rate when applied to clearance imaging studies. If further informed, this model may provide a valuable tool for studying small airways obstructive disease and evaluating mucus clearance-enhancing therapies in the lung.
Targeting Non-catalytic Sites of SRC Sensitizes the Efficacy of SRC Kinase Inhibitors in Solid Tumors
Authors: Yu Jinmei , Wang Xusheng , Liu Pengyue , Wang Zhenhe , Liu Jianli , Gan Tian , Xu Ning , Zhou Jichao , Yu Jiaojiao , Yuan Hongyu , Ban Xinchao , Liu Yuanzhen , Zhang Xiaowei , Li Pingping , Cui Bing 
Published: February 2025

AbstractThe non-catalytic functions of kinases have provided novel and crucial mechanisms underlying kinase inhibitor resistance, thereby presenting new opportunities for discovery of kinase-targeted drugs. Nevertheless, only a very limited modulators targeting non-catalytic functions have been reported. As the first discovered proto-oncogene, the non-receptor tyrosine kinase SRC promotes the progression of hematologic malignancies and numerous solid tumors via complex pathways. Several SRC kinase inhibitors were approved for the treatment of hematologic malignancies, yet not for solid tumors. The rapid development of resistance, attributed to the complexity of the signaling pathway, is a key factor restricting the application of SRC kinase inhibitors. The non-kinase function of SRC is one of the primary reasons, but the non-kinase function of SRC remains unclear. In this study, it was discovered that upon abrogation of phosphorylation by SRC kinase inhibitors, non-catalytic SRC promotes the transcription of the oncogenesTRIB3andSPC24transcription by binding to their promoter sequence. Simultaneously, it interacts with TRIB3 and mutually prevents the proteasome-mediated degradation by the E3 ligase CHIP, ultimately inducing resistance to SRC kinase inhibitors. The peptide TS1-2 inhibits the tumor progression of pancreatic ductal adenocarcinoma (PDAC), kidney renal papillary cell carcinoma (KIRP), kidney renal clear cell carcinoma (KIRC), liver hepatocellular carcinoma (LIHC), and breast invasive carcinoma (BRCA), and enhances the efficacy of SRC kinase inhibitors in solid tumors. This study elucidates the mechanism of non-catalytic functions of SRC, validates the tumor-promoting function and mechanism of nuclear accumulation of SRC/TRIB3 following SRC kinase inhibitor treatment, identifies a potential target SRC/TRIB3, and offers the candidate peptide TS1-2 as a new strategy for SRC kinase inhibitor resistance.Abstract Figure
Multiple pathways to the evolution of positive assortment in aggregative multicellularity
Authors: Stoy Kayla S. , MacGillivray Kathryn A. , Burnetti Anthony J. , Barrett Cornelia , Ratcliff William C. 
Published: February 2025

AbstractThe evolutionary transition to multicellularity requires shifting the primary unit of selection from cells to multicellular collectives. How this occurs in aggregative organisms remains poorly understood. Clonal development provides a direct path to multicellular adaptation through genetic identity between cells, but aggregative organisms face a constraint: selection on collective-level traits cannot drive adaptation without positive genetic assortment. We leveraged experimental evolution of flocculatingSaccharomyces cerevisiaeto examine the evolution and role of genetic assortment in multicellular adaptation. After 840 generations of selection for rapid settling, 13 of 19 lineages evolved increased positive assortment relative to their ancestor. However, assortment provided no competitive advantage during settling selection, suggesting it arose as an indirect effect of selection on cell-level traits rather than through direct selection on collective-level properties. Genetic reconstruction experiments and protein structure modeling revealed two distinct pathways to assortment: kin recognition mediated by mutations in theFLO1adhesion gene and generally enhanced cellular adhesion that improved flocculation efficiency independent of partner genotype. The evolution of assortment without immediate adaptive benefit suggests that key innovations enabling multicellular adaptation may arise indirectly through cell-level selection. Our results demonstrate fundamental constraints on aggregative multicellularity and help explain why aggregative lineages have remained simple.
Study of electron-positron annihilation into
KK¯π
within resonance chiral theory
Authors: Qin Bing-Hai , Qin Wen , Dai Ling-Yun 
Published: February 2025

In this paper, a coherent study of the e+e− annihilation into K+K−π0, KS0KL0π0, and KS0K±π∓ is carried out within the framework of resonance chiral theory. The amplitudes are fixed by fitting to the experimental cross section and invariant mass spectrum. With these amplitudes, one can calculate the hadronic vacuum polarization form factors of these processes. The leading order contributions of σ(e+e−→KK¯π) to the anomalous magnetic moment of the muon, (g−2)μ, is obtained as aμHVP,LO(e+e−→KK¯π)=(3.178±0.071)×10−10 up to Ecm=2.3  GeV.

Published by the American Physical Society
2025
Weakly nonlinear analysis of Turing pattern dynamics on curved surfaces
Authors: Nishide Ryosuke , Ishihara Shuji 
Published: February 2025

Pattern dynamics on curved surfaces are ubiquitous. Although the effect of surface topography on pattern dynamics has gained much interest, there is a limited understanding of the roles of surface geometry and topology in pattern dynamics. Recently, we reported that a static pattern on a flat plane can become a propagating pattern on a curved surface []. By examining reaction-diffusion equations on axisymmetric surfaces, certain conditions for the onset of pattern propagation were determined. However, this analysis was limited by the assumption that the pattern propagates at a constant speed. Here, we investigate the pattern propagation driven by surface curvature using weakly nonlinear analysis, which enables a more comprehensive approach to the aforementioned problem. The analysis reveals consistent conditions of the pattern propagation similar to our previous results, and further predicts that rich dynamics other than pattern propagation, such as periodic and chaotic behaviors, can arise depending on the surface geometry. This study provides a perspective on the relationship between surfaces and pattern dynamics and a basis for controlling pattern dynamics on surfaces.

Published by the American Physical Society
2025
Sensitivity of JWST to eV-Scale Decaying Axion Dark Matter
Authors: Roy Sandip , Blanco Carlos , Dessert Christopher , Prabhu Anirudh , Temim Tea 
Published: February 2025

The recently launched James Webb Space Telescope can resolve eV-scale emission lines arising from dark matter decay. We forecast the end-of-mission sensitivity to the decay of axions, a leading dark matter candidate, in the Milky Way using the blank-sky observations expected during standard operations. Searching for unassociated emission lines will constrain axions in the mass range 0.18 to 2.6 eV with axion-photon couplings gaγγ≳5.5×10−12  GeV−1. In particular, these results will constrain nucleophobic QCD axions to masses ≲0.2  eV.

Published by the American Physical Society
2025
Topological properties, exact solutions and chaotic behaviors for coupled Drinfel’d–Sokolov–Wilson equation with conformal derivative
Authors: Liu Mengyao , Xiao Xiang 
Published: February 2025

PurposeIn this paper, the dynamical properties and analytic solutions of the coupled Drinfel’d–Sokolov–Wilson equation with a conformal derivative are studied by the complete discrimination system for the polynomial method. Not only are the Hamiltonian and topological properties of this equation are presented, but also all exact traveling wave solutions are found.Design/methodology/approachThe complete discrimination system for the polynomial method serves as the cornerstone of the analytical approach, facilitating both the analysis of dynamic properties and the derivation of exact solutions for the equation under study.FindingsThe study shows that by adjusting specific parameters, various classified solutions such as rational function solutions, solitary wave solutions and periodic function solutions can be realized in practical applications. Furthermore, numerical analysis shows that the introduction of different external perturbation terms in the coupled Drinfel’d–Sokolov–Wilson equations with conformal derivative can confirm the presence of chaotic behaviors.Originality/valueThe coupled Drinfel’d–Sokolov–Wilson equation is analyzed qualitatively and quantitatively using the same method. Firstly, the dynamical system is analyzed qualitatively using a third-order discriminant system to predict the type of solutions. Then, use a fourth-order discriminant system to solve the exact solutions and maintain parameter consistency. This method ensures that the results of qualitative and quantitative analysis are achieved under the same set of parameters, thereby improving the coherence and reliability of the research.
Cooking unforgettable experiences: sensory marketing in slow food restaurants
Authors: Santos Mariana Alves , Dopico-Parada Ana , Cabanelas Pablo 
Published: February 2025

PurposeThis study aims to investigate the impact of gastronomic sensory experiences on customer intention to revisit. The paper analyses if sensory perception is positively related to experiential value and attempts to verify if customer satisfaction is positively related to post-purchase behaviour.Design/methodology/approachThe paper adopts a quantitative approach through structural equation modelling for analysing the data collected from 416 respondents in Portugal, a country well-known for its gastronomy.FindingsSensory perception positively impacts the experiential value in its functional and emotional dimensions. Furthermore, immediate customer satisfaction induces positive post-purchase behaviour regarding slow food restaurants.Practical implicationsThis study provides practical guidelines for managers to monitor customer satisfaction by applying sensory marketing techniques. Furthermore, slow food advocates for environmentally sustainable practices, social welfare and the preservation of biodiversity and local culinary traditions.Originality/valueSlow Food restaurants must remain authentic and sustainable to develop a traditional gastronomic experience. Sensory marketing is a marketing practice that uses senses to improve customers’ emotions and dining experiences. Although there are studies applied to the restaurant sector, there are hardly any applied to slow food.
Bordeaux and Napa Valley clusters – growing, sustaining, declining or renewing? A cluster life cycle perspective
Authors: Ostapenko Svitlana , Africano Ana Paula , Meneses Raquel 
Published: February 2025

Purpose
This study aims to investigate the dynamic nature of local economies through the lens of cluster life cycle (CLC) theory. The authors offer an original perspective on the comparison of the mature Old World wine industry and the growing New World one, viewed through the lens of the CLC aiming to understand the specific stage of cluster development for these regions. The authors aim to define the CLC dynamics of two world-renowned wine clusters, symbolizing these old and new world wine industries: Napa and Bordeaux.

Design/methodology/approach
The research adopts a case study approach, specifically analyzing the Bordeaux and Napa Valley wine clusters, using a CLC identification framework. This study integrates recent conceptual advances from evolutionary and institutional economic geography, incorporating a dynamic “path” approach to cluster development stages.

Findings
In examining Bordeaux, despite indications of maturity in the wine industry, the cluster displays signs of transformation, marked by reorganization, diversification and adaptation to new conditions, such as enotourism and technological clusters. In contrast, Napa Valley, while well established, exhibits characteristics of sustainment with stabilized business dynamics.

Research limitations/implications
This study acknowledges its exploratory nature and the need for future empirical studies on various clusters to fully validate and refine the CLC identification framework.

Practical implications
The proposed CLC identification framework serves as a valuable tool for policymakers and companies by facilitating precise identification of cluster development stages. This tool enables stakeholders to better understand and address the specific needs and characteristics of clusters at different stages, enhancing the effectiveness of targeted interventions and support measures.

Originality/value
This research advances CLC theory by introducing the development trajectories of the Napa and Bordeaux clusters, analyzed independently of their dominant industries, using the CLC path identification model. This approach provides a fresh perspective on cluster evolution, enriching the theoretical framework with insights that transcend traditional industry-specific analysis. By enhancing the precision and relevance of cluster stage identification, this research offers a valuable guide for policymakers and cluster stakeholders, enabling them to better understand the dynamics of cluster development and intervene effectively at critical stages.
Relative frugal wavelet transform to detect damages in functionally graded tapered beams made of porous material
Authors: Saadatmorad Morteza , Jafari-Talookolaei Ramazan-Ali , Ghandvar Hamidreza , Cuong-Le Thanh , Khatir Samir 
Published: February 2025

PurposeThis study aims to enhance singularity detection in non-stationary signals by introducing the frugal wavelet transform (FrugWT), a novel variation of the wavelet transform.Design/methodology/approachThe frugal wavelet transform, based on a modified first-level discrete wavelet transform decomposition, is compared with traditional discrete wavelet transform. The performance of these transforms is evaluated using signals derived from finite element analysis of a functionally graded tapered beam made of porous material.FindingsThe frugal wavelet transform significantly outperforms the discrete wavelet transform in detecting singularities within the analyzed signals. It offers more accurate detection of singularities and local abrupt changes, demonstrating its effectiveness for signal analysis.Originality/valueThis paper contributes to the field by proposing the relative frugal wavelet transform as a novel enhancement of the frugal wavelet transform. It provides a significant improvement in detecting subtle singularities in one-dimensional signals, with potential applications in advanced signal processing and analysis across various scientific domains such as electrical engineering, automotive, aerospace engineering, civil engineering, marine engineering and medical signal processing.
Family business philanthropy in Malaysia: a multi-case study
Authors: Ali Hasnita , Yu Kaidong 
Published: February 2025

Purpose
This study aims to investigate the role of family businesses in contributing to societal well-being through their philanthropic activities, with a particular focus on religious contexts. Grounded in stakeholder theory, the research aims to deepen the academic understanding of the motivations, strategies and outcomes associated with family business philanthropy, particularly in the context of Malaysia.

Design/methodology/approach
This qualitative study is based on 37 in-depth interviews conducted across four case studies of family-owned businesses. Data were analyzed to explore how these businesses engage in philanthropy and the impact of their efforts on both the recipients and the businesses themselves.

Findings
The findings reveal that family business philanthropy is primarily motivated by religious obligations and a desire to enhance community legitimacy. Family businesses focus on long-term social impacts, fostering community development and economic sustainability among recipients. These philanthropic activities not only contribute to societal well-being but also enhance the legitimacy and competitiveness of the businesses involved.

Originality/value
This study introduces the “Intention-Effort-Outcome” framework, offering a novel conceptual approach to understanding family business philanthropy. By highlighting the interconnections between motivation, effort and outcome, it expands current knowledge on the dynamic role of family businesses in religiously driven philanthropic efforts.
Driving environmental sustainability through synergistic green business practices and green innovation in developing economies’ leather, textile and garment industries
Authors: Habtemaryam Tilahun Nigatu , Degoma Aschalew , Tsegaye Abiot 
Published: February 2025

PurposeThis study investigated how green innovation (GINO), using practices like green marketing orientation (GMO), manufacturing (GMfP), investment (GINV) and HRM, improves environmental performance (EnP) in Ethiopian leather, textile and garment businesses.Design/methodology/approachThe study used a cross-sectional, quantitative design. It surveyed 201 participants, selected via stratified random sampling. Researchers examined the hypothesis using PLS-SEM.FindingsOur findings showed that green practices, especially GMP, GMO, GHRM, GINV and GINO, greatly boost firms’ environmental performance. GMP, GMO and GINV had a strong synergy on green innovation. GHRM had no significant effect. Except for GHRM, results showed that green innovation helps most green practices. It links them to better environmental performance.Practical implicationsFor managers and policymakers working in the leather, textile and apparel industries in Ethiopia, this report provides insightful information. Strategic planning that supports and prioritizes the adoption of green practices is shown to be essential. Such activities are expected to improve corporate competitiveness and green innovation, ultimately resulting in ecologically sustainable performance.Originality/valueUnique findings illuminate emerging nations’ leather, textile and apparel industries. This pioneering study reveals critical links that were previously unexplored. Its relevance extends across developing economies, offering fresh insights into these interconnected sectors.
Employee suicide: what HR needs to know
Authors: Haymore John , Haymore Angelica 
Published: February 2025

Purpose
The study examines suicide and its impact on employees and the organization. The paper aims to raise awareness of employee suicide and provide practical recommendations for fostering a more supportive and healthy work environment.

Design/methodology/approach
Through a review of recent literature and government reports, the study presents a conceptual framework of employee suicide, and how suicidal ideology may be exasperated by an unhealthy work environment and a lack of training and organizational support.

Findings
The study found that suicide is a growing concern among working-aged individuals. In the US alone, nearly 50,000 people die by suicide each year. For every suicide, there are an estimated 20 other individuals who attempt to take their own lives.

Research limitations/implications
Future research should focus on the role of well-being and anti-violence human resource practices that help support employee coping and prevent future incidents.

Practical implications
This study builds on recent research to highlight the importance of HR practices, training and organizational support to help prevent suicide among employees.

Social implications
Suicide has a traumatic impact not only on the individual who dies but, on their family members, friends, colleagues, the organization and the local community.

Originality/value
This paper adds to our understanding of suicide and its impact on the workplace. Future research should explore the role of well-being and anti-violence human resource practices that help support employee coping and prevent future incidents.