bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three‐dimensional simulations of six treatment maneuvers for horizontal canal benign paroxysmal positional vertigo canalithiasis
Authors: Bhandari Anita , Bhandari Rajneesh , Kingma Herman , Zuma e Maia Francisco , Strupp Michael 
Published: August 2021

AbstractBackground and purposeHorizontal canal benign paroxysmal positional vertigo (BPPV) is the second most common variant of BPPV after posterior canal BPPV. Various liberatory maneuvers are recommended for the treatment of horizontal canal BPPV canalithiasis (hc‐BPPV‐ca). The aim of this study was to show how three‐dimensional (3D) dynamic simulation models visualize the movement of the clot of otoconia within the canal for a better understanding of the theoretical efficacy.MethodsBased on reconstructed magnetic resonance imaging and fluid dynamics, a 3D dynamic simulation model (as a function of time) was developed and applied. Thereby, six treatment maneuvers for hc‐BPPV‐ca were simulated: two types of the roll maneuver (the original 270° and the modified 360°) as well as two Gufoni and Zuma maneuvers (for geotropic and apogeotropic nystagmus).ResultsThe simulations showed that the 360° roll maneuver and Zuma maneuver are effective treatment options for hc‐BPPV‐ca for debris in all locations within the canal. However, the original 270° roll maneuver will not be effective if the clot is in the ampullary arm of the horizontal canal. The Gufoni maneuver for geotropic hc‐BPPV‐ca is effective, whereas for apogeotropic hc‐BPPV‐ca there is a risk of treatment failure due to insufficient repositioning of the debris.ConclusionsThe 3D simulations for movement of the otoconia clots can be used to test the mechanism of action and the theoretical efficacy of existing maneuvers for the different BPPV variants. For hc‐BPPV‐ca, the modified 360° roll maneuver and Zuma maneuver are theoretically efficient for all subtypes, whereas Gufoni maneuver is effective for geotropic nystagmus only.
Improving the prediction of epilepsy surgery outcomes using basic scalp EEG findings
Authors: Fitzgerald Zachary , Morita‐Sherman Marcia , Hogue Olivia , Joseph Boney , Alvim Marina K. M. , Yasuda Clarissa L. , Vegh Deborah , Nair Dileep , Burgess Richard , Bingaman William , Najm Imad , Kattan Michael W. , Blumcke Ingmar , Worrell Gregory , Brinkmann Benjamin H. , Cendes Fernando , Jehi Lara 
Published: August 2021

AbstractObjectiveThis study aims to evaluate the role of scalp electroencephalography (EEG; ictal and interictal patterns) in predicting resective epilepsy surgery outcomes. We use the data to further develop a nomogram to predict seizure freedom.MethodsWe retrospectively reviewed the scalp EEG findings and clinical data of patients who underwent surgical resection at three epilepsy centers. Using both EEG and clinical variables categorized into 13 isolated candidate predictors and 6 interaction terms, we built a multivariable Cox proportional hazards model to predict seizure freedom 2 years after surgery. Harrell's step‐down procedure was used to sequentially eliminate the least‐informative variables from the model until the change in the concordance index (c‐index) with variable removal was less than 0.01. We created a separate model using only clinical variables. Discrimination of the two models was compared to evaluate the role of scalp EEG in seizure‐freedom prediction.ResultsFour hundred seventy patient records were analyzed. Following internal validation, the full Clinical + EEG model achieved an optimism‐corrected c‐index of 0.65, whereas the c‐index of the model without EEG data was 0.59. The presence of focal to bilateral tonic‐clonic seizures (FBTCS), high preoperative seizure frequency, absence of hippocampal sclerosis, and presence of nonlocalizable seizures predicted worse outcome. The presence of FBTCS had the largest impact for predicting outcome. The analysis of the models’ interactions showed that in patients with unilateral interictal epileptiform discharges (IEDs), temporal lobe surgery cases had a better outcome. In cases with bilateral IEDs, abnormal magnetic resonance imaging (MRI) predicted worse outcomes, and in cases without IEDs, patients with extratemporal epilepsy and abnormal MRI had better outcomes.SignificanceThis study highlights the value of scalp EEG, particularly the significance of IEDs, in predicting surgical outcome. The nomogram delivers an individualized prediction of postoperative outcome, and provides a unique assessment of the relationship between the outcome and preoperative findings.
The woman writer's body: Multiplicity, neoliberalism, and feminist resistance
Authors: Quah Sharon Ee Ling , Ridgway Alexandra 
Published: August 2021

AbstractWhat goes behind the scene of a woman writer's writing process? Beneath shiny finished writing products lies an arduous writing process often remain unseen to readers. The article makes visible two women writers' bodies and our embodied writing experiences through an intersectional feminist lens. Writer One is a Singapore‐born, ethnic Chinese, queer migrant woman academic residing in Australia with her long‐term partner. Writer Two is an England‐born, Australian‐British dual citizen, white heterosexual married mother of young twin children ready to kick start her academic career after her recent PhD conferment. Writer One with her fibromyalgic, traumatized, and othered bodies and Writer Two with her vulvodynia, mothering, and gendered bodies write themselves, their bodies and embodied writing experiences into existence in this article. Using autoethnographic accounts, they discuss how their multiple, chronically ill, and pained bodies influence their writing process and choice of writing topics. Specifically, they reveal how their bodies negotiate the tension between neoliberal demands imposed on their bodies and their feminist resistance efforts against constrictive forces in the knowledge production economy. Using this piece of writing as feminist resistance, they seek to reject dominant discourses, hold space, inscribe their own narratives, and call for collective feminist action with fellow women writers.
Preference‐based patient participation for most, if not all: A cross‐sectional study of patient participation amongst persons with end‐stage kidney disease
Authors: Martinsson Caroline , Uhlin Fredrik , Wenemark Marika , Eldh Ann Catrine 
Published: August 2021

AbstractBackgroundPatient participation is considered central for good healthcare. Yet, the concept is not fully understood when it comes to patients' experiences of participation in conjunction with their preferences, particularly in long‐term healthcare. The aim of this study was to investigate the extent and variation of preference‐based patient participation in patients with end‐stage kidney disease (ESKD).MethodsA cross‐sectional study was conducted with 346 patients in renal care. The main variables were patients' preferences for and experiences of patient participation, determined using the Patient Preferences for Patient Participation tool, the 4Ps. Analyses identified the degree of match between preferences and experiences, that is, the preference‐based patient participation measure.ResultsOverall, 57%–84% of the patients reached a sufficient level of preference‐based patient participation on the items, while 2%–12% reached an insufficient level. A mismatch indicated either less or more participation than preferred; for example, 40% had less experience than preferred for taking part in planning, and 40% had more than preferred for managing treatment.ConclusionThis study shows that, although many patients reach a sufficient level of preference‐based patient participation, this is not the case for all patients and/or attributes. Further opportunities for a mutual understanding of patients' preferences are needed for healthcare professionals to support person‐centred patient participation.Patient or Public ContributionThe 4Ps is manufactured in collaboration with people with experience of the patient role, and persons living with ESKD were engaged in identifying their preferences and experiences of participation in renal care.
Clinical utility of Abbott Alinity hq extended red blood cell parameters in differentiating β‐thalassemia trait and iron deficiency anemia
Authors: Mukhtar Zainab , Valente Sabatino , Masi Loredana , Lakos Gabriella , Papa Fabrizio 
Published: August 2021

AbstractIntroductionThe objective of the study was to evaluate the performance of the Abbott Alinity hq advanced multi angle polarized scatter separation (MAPSSTM)‐based optical RBC technology, for the differentiation between iron deficiency anemia (IDA) and β‐thalassemia carrier status.MethodsFour hundred and sixty‐four samples were analyzed. 228 were healthy controls, 30 were β‐thalassemia carriers, and 40 were IDA. Receiver operating characteristics analysis evaluated the performance of red cell parameters and mathematical formulas.ResultsRBC concentration was the most efficient discriminant (area under the curve; AUC of 0.963, Youden Index of 0.88) followed by red blood cell distribution width in size distribution (AUC of 0.960 and YI of 0.86), and red blood cell distribution width coefficient of variation (AUC of 0.924, and YI of 0.74). The absolute reticulocyte concentration showed good diagnostic efficiency, with AUC of 0.808. Hemoglobin distribution width, the %CV of directly measured cellular hemoglobin concentration, and CHCr, the average hemoglobin concentration of reticulocytes have emerged as novel discriminating parameters, with AUC of 0.749 and 0.785, respectively.The England and Fraser index was the best discriminating mathematical formula based on Youden Index of 0.91. The Ricerca, red blood cell distribution width index, Green and King, and Mentzner Index formulas also showed strong discriminative power. The Shine and Lal index, together with the recent mathematical formula M/H, (ratio of percent microcytic and hypochromic red blood cells) demonstrated moderate performance with AUC of 0.796 and 0.740, respectively.ConclusionExtended red cell analysis delivered by the advanced optical technology on the Alinity hq hematology analyzer has efficient diagnostic utility in the initial discrimination of the two most common microcytic anemias: IDA and β‐thalassemia trait.
Quality of care in people requiring hospital admission for gout in Aotearoa New Zealand: a nationwide analysis
Authors: Murdoch Rachel , Jones Peter , Greenwell James , Dalbeth Nicola 
Published: August 2021

AbstractBackgroundThe quality of care for patients admitted with a primary diagnosis of gout, both before and after admission, has not been systematically examined.AimsTo understand national trends in hospital admission for a primary diagnosis of gout in Aotearoa New Zealand over the past 10 years and the quality of care for gout received by these patients before and after the admission.MethodsData from the Aotearoa New Zealand National Collections from 1 January 2007 to 31 December 2019 were analysed to determine rates of hospital admission for a primary diagnosis of gout. Admission data include cost−weight analysis, as well as quality of care data including gout‐specific medication dispensing in the year prior and year after admission.ResultsThere were 13 721 admissions with a primary diagnosis of gout over the analysis period, with an average cost per admission in 2019 of NZ$4301. The rate of admission per 100 000 population was highest in Pacific peoples followed by Māori. Although dispensing of any allopurinol increased in the year after admission, rates of regular allopurinol dispensing remained low; 38.1% for admissions in 2018. Patients who were younger (especially 20–44 years), not enrolled in a primary health organisation before admission and female had lower rate of regular allopurinol after admission.ConclusionIn this nationwide study, rates of admission for gout were highest in Pacific peoples and in Māori. Rates of regular allopurinol dispensing were low even after admission for a primary diagnosis of gout. These findings highlight the need for improvements in gout management in Aotearoa New Zealand, including in post‐discharge planning from secondary care inpatient services.
A critical analysis of vulnerability in informal sector employment in India: Protective mechanisms and adequacy of protection
Authors: Khan Ghazala Ali 
Published: August 2021

AbstractThe measure of a civilized society, is how well it is able to protect its weakest and most vulnerable members. Vulnerable workers typically comprise very young and elderly workers, and disabled, indigent, and sick workers, usually employed in unregulated informal sector jobs. This study seeks to study the prevalence of vulnerability among workers in India, both physical and economic, occasioned by informality of their employment. It looks into the kind and degree of vulnerability faced by workers in informal sector occupations, in part by comparing with similar workers in formal employment, and checks whether protective mechanisms and safety nets are required, mandated, and in place, in the form of food transfers, medical treatment, income support, or subsidies. Relying on primary data, this study seeks to assess the actual availability and adequacy of social protection in terms of access and enforceability, gaps and reasons thereof, including barriers to take‐up, and concludes that gaps in implementation and targeting are the primary reasons for the prevalence of vulnerability in informal employment.
Long non‐coding RNAs in diabetic wound healing: Current research and clinical relevance
Authors: Kuai Le , Jiang Jing‐Si , Li Wei , Li Bin , Yin Shuang‐Yi 
Published: August 2021

AbstractDiabetic wounds are a protracted complication of diabetes mainly characterised by chronic inflammation, obstruction of epithelialization, damaged blood vessels and collagen production (maturation), as well as neuropathy. As a non‐coding RNA (ncRNA) that lack coding potential, long non‐coding RNAs (lncRNAs) have recently been reported to play a salient role in diabetic wound healing. Here, this review summarises the roles of lncRNAs in the pathology and treatments of diabetic wounds, providing references for its potential clinical diagnostic criteria or therapeutic targets in the future.
Should charitable acts be private or publicly visible? A dilemma for charitable organizations
Authors: Kao Danny Tengti , Lin Chih‐Ming 
Published: August 2021

AbstractWhile the subject of egoism/altruism has been widely explored in psychology literature, deeper understanding of the effects of egoism/altruism on charitable supporters' emotional responses to charitable appeals is promising but underexplored. Therefore, this research aims to apply cases of egoism/altruism and self‐referencing to examine whether the style of private vs. public recognition can moderate charitable supporters' willingness to donate. The experiment investigated the effect of egoism/altruism on charitable supporters' evaluations of the charitable appeals, through viewing a series of print posters that varied in private/public recognition and low/high self‐referencing. A total of 225 participants recruited from working students who have a full‐time job and enrolled in marketing courses in a mid‐western university in China were randomly assigned to a 2 (recognition style: private vs. public) × 2 (self‐referencing: low vs. high) between‐subjects factorial design. Results demonstrate that for charitable supporters with altruistic and egoistic dispositions, charitable appeals characterized by private vs. public recognition and low vs. high self‐referencing will elicit differential willingness to donate. This research takes up the call to address the limited attention given to private vs. public recognition in the context of charitable giving. Specifically, this research aims to explore how charitable supporters' altruism vs. egoism influences their willingness to donate and the role of moderating effects such as private vs. public recognition and self‐referencing in this context.
Integration of RNA‐seq and RNAi reveals the contribution of znuA gene to the pathogenicity of Pseudomonas plecoglossicida and to the immune response of Epinephelus coioides
Authors: He Le , Wang Luying , Zhao Lingmin , Zhuang Zhixia , Wang Xiaoru , Huang Huabin , Fu Qi , Huang Lixing , Qin Yingxue , Wang Pan , Yan Qingpi 
Published: August 2021

AbstractPseudomonas plecoglossicida is an important pathogen in aquaculture and causes serious economic losses. Our previous study indicated that znuA gene might play an important role in the pathogenicity of P. plecoglossicida. Five shRNAs were designed and synthesized to silence the znuA gene of P. plecoglossicida. Two of the five mutants of P. plecoglossicida exhibited significant reduction in the expression level of znuA mRNA with different efficiencies. The mutant with the highest silencing efficiency of 89.2% was chosen for further studies. Intrapleural injection of the znuA‐RNAi strain at a dose of 105 cfu/fish did not cause the death of Epinephelus coioides, and no significant signs were observed at the spleen surface of infected E. coioides, while the counterpart E. coioides infected by the same dose of wild‐type strain of P. plecoglossicida all died in 5 days post‐infection (dpi). The expression of znuA gene of znuA‐RNAi strain in E. coioides was always lower than that in wild‐type strain of P. plecoglossicida. The pathogen load in the early stage of infection was higher than that in the later stage of infection. Although the infection of the znuA‐RNAi strain of P. plecoglossicida could induce the production of antibodies in E. coioides, it failed to produce a good immune protection against the infection of wild‐type strain of P. plecoglossicida. Compared with the transcriptome data of E. coioides infected by the wild‐type strain of P. plecoglossicida, the transcriptome data of E. coioides infected by the znuA‐RNAi strain of P. plecoglossicida have altered significantly. Among them, KEGG enrichment analysis showed that the focal adhesion pathway was significantly enriched and exhibited the largest number of 302 DEMs (differentially expressed mRNAs). These results showed that the immune response of E. coioides to P. plecoglossicida infection was significantly affected by the RNAi of znuA gene.
A 343 Italian cohort of patients analysed with array‐comparative genomic hybridization: unsolved problems and genetic counselling difficulties
Authors: Palka Bayard de Volo C. , Alfonsi M. , Morizio E. , Guaciali‐Franchi P. , Mohn A. , Chiarelli F. 
Published: August 2021

AbstractBackgroundThe recent introduction of microarrays for genetic analyses has allowed higher etiological diagnostic rates in patient with intellectual disability (ID), autism spectrum disorders (ASD), epilepsy and multiple congenital anomalies (MCA), because of its resolution. This approach still results of high complexity and some limitations have been reported. In fact, it discloses several variants of unknown significance (VOUS) or incidental findings. In all cases, a massive amount of data is generated, because of this, the analysis and the interpretation is very difficult and often without a definitive conclusion.MethodWe analysed an Italian cohort of 343 patients with ID, MCA and ASD by array‐comparative genomic hybridization. The purpose of this work was to consider the proportion of the chromosomal abnormalities in such cohort and to assess the distribution of the different type of the chromosomal abnormalities concerning their pathogenic significance, their origin and their correlation to these clinical phenotypes.ResultsArray‐comparative genomic hybridization analysis revealed 76 positive results. Abnormalities were detected in 27.8% of patients with ID, 11.1% with ASD, 10.7% with epilepsy and 19.4% with multiple congenital anomalies. The anomalies were classified in three major groups: group 1 (27 patients) with pathogenic alterations (P group); group 2 (34 patients) with VOUS potentially pathogenic (PP group); and group 3 (13 patients) with VOUS potentially benign (PB group). As expected, comparing the diagnostic groups, we observed a greater number of deletions in the P group and that all the abnormalities of the PB group were inherited.ConclusionsOur retrospective study resulted in confirming the high detection rate of microarrays. CNV classification remains a complex procedure. The difficulty in CNV classification points out the importance of the patient selection, helping the interpretation of the molecular cytogenetic results.
Fighting Fire with Gasoline: CoCos in Lieu of Equity
Authors: GONCHARENKO ROMAN 
Published: August 2021

AbstractIn this paper, I theoretically examine the ability of contingent convertible bonds (CoCos), a source of bank capital under Basel III, to reduce the bank's default risk. Although issuing CoCos adds a buffer to the bank's balance sheet, it may induce wrong incentives in the form of debt overhang and risk shifting. My results indicate that the most popular type of CoCos, temporary write‐down (TWD), is least effective at mitigating default risk. Unlike other types of CoCos, TWDs continue affecting shareholders' incentives even after the trigger event, thereby inducing an earlier endogenous default.
Fragile X mental retardation protein‐regulated proinflammatory cytokine expression in the spinal cord contributes to the pathogenesis of inflammatory pain induced by complete Freund's adjuvant
Authors: Yang Yixin , Zhao Jinsong , Li Yunze , Li Xiangyao , Chen Xiaowei , Feng Zhiying 
Published: August 2021

AbstractStudies have verified that Fragile X mental retardation protein (FMRP), an RNA‐binding protein, plays a potential role in the pathogenesis of formalin‐ and (RS)‐3,5‐dihydroxyphenylglycine‐induced abnormal pain sensations. However, the role of FMRP in inflammatory pain has not been reported. Here, we showed an increase in FMRP expression in the spinal dorsal horn (SDH) in a rat model of inflammatory pain induced by complete Freund's adjuvant (CFA). Double immunofluorescence staining revealed that FMRP was mainly expressed in spinal neurons and colocalized with proinflammatory cytokines [tumor necrosis factor‐α (TNF‐α) and interleukin‐6 (IL‐6)]. After consecutive intrathecal injection of fragile X mental retardation 1 small interfering RNA for 3 days post‐CFA injection, FMRP expression in the SDH was reduced, and CFA‐induced hyperalgesia was decreased. In addition, the CFA‐induced increase in spinal TNF‐α and IL‐6 production was significantly suppressed by intrathecal administration of fragile X mental retardation 1 small interfering RNA. Together, these results suggest that FMRP regulates TNF‐α and IL‐6 levels in the SDH and plays an important role in inflammatory pain.
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Indigenous Theory Uses, Abuses, and Future
Authors: Bruton Garry D. , Zahra Shaker A. , Van de Ven Andrew H. , Hitt Michael A. 
Published: August 2021

AbstractManagement theories developed in the United States and Europe have dominated management and organizational studies. As a result, scholars often overlook subtle cultural and ideological differences in other settings as they treat the theories from the United States and Europe as universal. All too often, as they attempt to apply these theories, scholars ignore critical research questions relevant to groups of people outside the United States and Europe. To overcome this shortcoming, Filatotchev, Ireland, and Stahl (in this issue) propose an open systems perspective that draws on multiple universal theories. Instead, we argue that such a solution does not address the fundamental problem of theories framed within the United States and European perspective. Using more of these theories does not solve this problem and may even exacerbate it. We argue, rather than simply placing bandages on existing theories, scholars should develop indigenous theory based on the distinctiveness of local contexts. The use of indigenous theory can also spur innovations in research methods, enhancing the rigor and relevance of findings.