bluuebunny/crossref_metadata_2025_split huggingface dataset:
Airway recanalization of bronchial metastasis and obstruction by smooth muscle tumour of uncertain malignant potential by a silicone OKI‐stent™
Authors: Torii Atsushi , Saka Hideo , Nishimura Rieko , Saito Yushi , Oki Masahide 
Published: June 2021

Key messageThere is no standard treatment for smooth muscle tumour of uncertain malignant potential (STUMP) but it usually has a good prognosis. Airway stenting is performed to manage central airway patency. In the present case, it was no treatment for STUMP, but performance status was good, so airway stenting was performed.
Post‐polypectomy surveillance colonoscopy: Comparison of the updated guidelines
Authors: Abu‐Freha Naim , Katz Lior H. , Kariv Revital , Vainer Elez , Laish Ido , Gluck Nathan , Half Elizabeth E. , Levi Zohar 
Published: June 2021

AbstractBackgroundRecently, three updated guidelines for post‐polypectomy colonoscopy surveillance (PPCS) have been published. These guidelines are based on a comprehensive summary of the literature, while some recommendations are similar, different surveillance intervals are recommended after detection of specific types of polyps.AimIn this review, we aimed to compare and contrast these recommendations.MethodsThe updated guidelines for PPCS were reviewed and the recommendations were compared.ResultsFor patients with 1–4 adenomas <10 mm with low‐grade dysplasia, irrespective of villous components, or 1–4 serrated polyps <10 mm without dysplasia, the European Society of Gastrointestinal Endoscopy (ESGE) and British Society of Gastroenterology (BSG), the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and Public Health England (PHE) (BSG/ACPGBI/PHE) guidelines do not recommend colonoscopic surveillance and instead recommend that the participate in routine CRC screening program (typically based on the fecal immunochemical test), while the USMSTF recommends surveillance colonoscopies 7–10 years after diagnosis of 1–2 tubular adenomas <10 mm and 3–5 years for 3–4 tubular adenomas of the same size. The USMSTF define adenomas with tubulovillous or villous histology as high‐risk adenomas; thus, surveillance colonoscopy is recommended after 3 years. However, the ESGE and BSG do not consider such histology as a criterion for repeating colonoscopy at this short interval. For patients with 1–2 sessile serrated polyps (SSPs) <10 mm and those with 3–4 SSPs <10 mm, the USMSTF recommends surveillance colonosocopy after 5–10 and 3–5 years, respectively.
Characterization of Pre-bond Contamination and Aging Effects for CFRP Bonded Joints Using Reference Laboratory Methods, Mechanical Tests, and Numerical Simulation
Authors: Tserpes Konstantinos , Moutsompegka Elli , Schlag Mareike , Brune Kai , Tornow Christian , Reguero Simón Ana , Ecault Romain 
Published: June 2021

AbstractIn this chapter, the pre-bond contamination and ageing effects on carbon fiber reinforced plastic (CFRP) adherends and CFRP bonded joints are characterized by means of reference laboratory non-destructive testing (NDT) methods, mechanical tests, and numerical simulation. Contaminations from two fields of application are considered, namely in aircraft manufacturing (i.e. production) and for in-service bonded repair. The production-related scenarios comprise release agent, moisture, and fingerprint, while the repair-related scenarios comprise fingerprint, thermal degradation, de-icing fluid, and a faulty curing of the adhesive. For each scenario, three different levels of contamination were pre-set and applied, namely low, medium and high level. Furthermore, two types of samples were tested, namely coupons and pilot samples (a stiffened panel and scarf repairs). The CFRP adherends were contaminated prior to bonding and the obtained surfaces were characterized using X-ray photoelectron spectroscopy. After bonding, the joints were tested by ultrasonic testing. To characterize the effects of each contamination on the strength of the bonded joints, mode-I and mode-II fracture toughness tests, and novel centrifuge tests were conducted on the coupons, while tensile tests were performed on the scarfed samples. Additionally, numerical simulation was performed on CFRP stiffened panels under compression using the LS-DYNA finite element (FE) platform.
Integrating Extended Non-destructive Testing in the Life Cycle Management of Bonded Products—Some Perspectives
Authors: Leite Cavalcanti Welchy , Moutsompegka Elli , Tserpes Konstantinos , Malinowski Paweł H. , Ostachowicz Wiesław M. , Ecault Romain , Grundmann Neele , Tornow Christian , Noeske Michael , Schiffels Peter , Mayer Bernd 
Published: June 2021

AbstractIn this chapter, we outline some perspectives on embracing the datasets gathered using Extended Non-destructive Testing (ENDT) during manufacturing or repair process steps within the life cycle of bonded products. Ensuring that the ENDT data and metadata are FAIR, i.e. findable, accessible, interoperable and re-usable, will support the relevant stakeholders in exploiting the contained material-related information far beyond a stop/go decision, while a shorter time-to-information will facilitate a prompter time-to-decision in process and product management. Exploiting the value of ENDT (meta)data will contribute to increased performance by integrating all defined, measured, analyzed and controlled aspects of material transformation across process and company boundaries. This will facilitate the optimization of manufacturing and repair operations, boosting their energy efficiency and productivity. In this regard, some aspects that are currently driving activities in the field of pre-process, in-process and post-process quality assessment will be addressed in the following. Furthermore, some requirements will be contemplated for harmonized and conjoint data transfer ranging from a bonded product’s beginning-of-life through its end-of-life, the customization of stand-alone or linked ENDT tools, and the implementation of sensor arrays and networks in joints, devices and structural parts to gather material-related data during a product’s middle-of-life application phase, thereby fostering structural health monitoring (SHM).
Efficacy of Splenectomy for Proximal Gastric Cancer with Greater Curvature Invasion or Type 4 Tumor: a Propensity Score Analysis of a Multi‐Institutional Dataset
Authors: Ito Seiji , Kanda Mitsuro , Mochizuki Yoshinari , Teramoto Hitoshi , Ishigure Kiyoshi , Murai Toshifumi , Asada Takahiro , Ishiyama Akiharu , Matsushita Hidenobu , Tanaka Chie , Kobayashi Daisuke , Fujiwara Michitaka , Murotani Kenta , Kodera Yasuhiro 
Published: June 2021

AbstractBackgroundSplenectomy for proximal gastric cancer was found to have no survival benefit in a randomized trial clarifying the role of splenectomy (JCOG0110 study). However, since tumor with invasion to the greater curvature and Type 4 tumor were excluded in JCOG0110, the benefit of splenectomy for these tumors is not known.MethodsA multicenter dataset of patients with gastric cancer who underwent gastrectomy between 2010 and 2014 was created. From the dataset, 114 eligible patients with proximal advanced gastric cancer with invasion to the greater curvature or Type 4 tumor were enrolled. There were 60 patients in the gastrectomy with splenectomy (Spx) group and 54 patients in the spleen‐preserving (Prs) group. To balance the essential variables, propensity score analysis was performed, estimating the propensity score with a logistic regression model. Adjusted overall survival (OS) and adjusted disease‐free survival (DFS) were estimated using the inverse probability of treatment weighting (IPTW) method.ResultsThere were significant differences in age, performance status, comorbidity, macroscopic type, and clinical T stage between the Spx and Prs groups. The model for estimating the propensity score was well adapted (c‐statistic: 0.830, 95%CI: 0.754–0.906). Adjusted OS was identical between the two groups (HR = 1.089, 95%CI: 0.759–1.563; p = 0.644). The DFS curve of Prs group was consistently tended to be lower than Spx, but the difference was not significant (HR = 0.813, 95%CI: 0.572–1.156; p = 0.249).ConclusionsThe efficacy of splenectomy was minimal for proximal advanced gastric cancer even with invasion to the greater curvature or Type 4 tumor.
Erfahrungen und Sichtweisen von Pflegeheimbewohnenden mit depressiver Symptomatik während der COVID-19-Pandemie: eine qualitative Studie
Authors: Schweighart Roxana , Klemmt Malte , Neuderth Silke , Teti Andrea 
Published: June 2021

Zusammenfassung
Hintergrund
Die COVID-19-Pandemie erfordert umfangreiche Maßnahmen in Pflegeheimen mit dem Ziel der Infektionsvermeidung. Diese Maßnahmen wirken sich auf das Leben der Bewohnenden aus und führen u. a. zu einer Zunahme an Depressivität und anderen negativen Begleiterscheinungen.

Ziel der Arbeit
Die Studie hat die Exploration der Erfahrungen und Sichtweisen von Pflegeheimbewohnenden mit depressiver Symptomatik während der Pandemie zum Ziel.

Methoden
Es wurden 9 leitfadengestützte Interviews mit Bewohnenden geführt, welche mittels der inhaltlich-strukturierenden Inhaltsanalyse nach Kuckartz ausgewertet wurden.

Ergebnisse
Es konnten 3 Hauptthemen identifiziert werden: Empfindungen und Emotionen in Bezug auf die Pandemie, Veränderungen und Einschränkungen durch die Maßnahmen sowie Wünsche vor dem Hintergrund der Pandemie. Die befragten Bewohnenden berichten sowohl von emotionalen Belastungen als auch davon, keine Angst vor einer Infektion und deren Folgen zu haben. Zudem äußern die Befragten z. T. unangenehme Einschränkungen wie das Tragen von Masken, deren Nutzen sie bisweilen kritisch hinterfragen. Weiter werden diverse Wünsche der Bewohnenden in Bezug zur Pandemie wie etwa das Verlassen des Pflegeheims identifiziert.

Diskussion
Die Studie zeigt komplexe Empfindungen, Veränderungen und Wünsche bei Pflegeheimbewohnenden aufgrund der Pandemie und der daraus resultierenden Maßnahmen. Dies erfordert einen individuellen Zugang zu den Bewohnenden mit depressiver Symptomatik, um eine Zunahme psychischer Probleme zu vermeiden. Vor diesem Hintergrund ergibt sich die Notwendigkeit einer partizipativen Umsetzung der Gesundheitsschutzmaßnahmen bei der besonders vulnerablen Gruppe der Pflegeheimbewohnenden.
Integrated energy-water-land nexus planning in the Colorado River Basin (Argentina)
Authors: Wild Thomas B. , Khan Zarrar , Clarke Leon , Hejazi Mohamad , Bereslawski Julia Lacal , Suriano Micaela , Roberts Paula , Casado José , Miralles-Wilhelm Fernando , Gavino-Novillo Marcelo , Muñoz-Castillo Raul , Moreda Fekadu , Zhao Mengqi , Yarlagadda Brinda , Lamontagne Jonathan , Birnbaum Abigail 
Published: June 2021

AbstractIntegrated energy-water-land (EWL) planning promotes synergies and avoids conflicts in ways that sector-specific planning approaches cannot. Many important decisions that influence emerging EWL nexus issues are implemented at regional (e.g., large river basin, electricity grid) and sub-regional (e.g., small river basin, irrigation district) scales. However, actual implementation of integrated planning at these scales has been limited. Simply collecting and visualizing data and interconnections across multiple sectors and sub-regions in a single modeling platform is a unique endeavor in many regions. This study introduces and applies a novel approach to linking together multiple sub-regions in a single platform to characterize and visualize EWL resource use, EWL system linkages within and among sub-regions, and the EWL nexus implications of future policies and investments. This integrated planning methodology is applied in the water-stressed Colorado River Basin in Argentina, which is facing increasing demands for agricultural and fossil fuel commodities. Guided by stakeholders, this study seeks to inform basin planning activities by characterizing and visualizing (1) the basin’s current state of EWL resources, (2) the linkages between sectors within and among basin sub-regions, and (3) the EWL nexus implications of planned future agricultural development activities. Results show that water scarcity, driven in part by human demands that have historically reached 60% of total surface water supply, poses a substantial constraint to economic development in the basin. The Colorado basin has the potential to serve as a testbed for crafting novel and generalizable sub-regional EWL planning approaches capable of informing the EWL planning dialogue globally.
Unilateral climate policies can substantially reduce national carbon pollution
Authors: Lépissier Alice , Mildenberger Matto 
Published: June 2021

AbstractFollowing the failure of climate governance regimes that sought to impose legally binding treaty-based obligations, the Paris Agreement relies on voluntary actions by individual countries. Yet, there is no guarantee that unilateral policies will lead to a decrease in carbon emissions. Critics worry that voluntary climate measures will be weak and ineffective, and insights from political economy imply that regulatory loopholes are likely to benefit carbon-intensive sectors. Here, we empirically evaluate whether unilateral action can still reduce carbon pollution by estimating the causal effect of the UK’s 2001 Climate Change Programme (CCP) on the country’s carbon emissions. Existing efforts to evaluate the overall impact of climate policies on national carbon emissions rely on Business-As-Usual (BAU) scenarios to project what carbon emissions would have been without a climate policy. We instead use synthetic control methods to undertake an ex post national-level assessment of the UK’s CCP without relying on parametric BAU assumptions and demonstrate the potential of synthetic control methods for climate policy impact evaluation. Despite setting lax carbon targets and making substantial concessions to producers, we show that, in 2005, the UK’s CO2 emissions per capita were 9.8% lower relative to what they would have been if the CCP had not been passed. Our findings offer empirical confirmation that unilateral climate policies can still reduce carbon emissions, even in the absence of a binding global climate agreement and in the presence of regulatory capture by industry.
On the Costs of Classical Logic
Authors: Castaldo Luca 
Published: June 2021

AbstractThis article compares classical (or -like) and nonclassical (or -like) axiomatisations of the fixed-point semantics developed by Kripke (J Philos 72(19): 690–716, 1975). Following the line of investigation of Halbach and Nicolai (J Philos Logic 47(2): 227–257, 2018), we do not compare and qua theories of truth simpliciter, but rather qua axiomatisations of the Kripkean conception of truth. We strengthen the central results of Halbach and Nicolai (2018) and Nicolai (Stud Log 106(1): 101–130, 2018), showing that, on the one hand, there is a stronger sense in which some variants of and some variants of can be taken to be, truth-theoretically, equivalent. On the other hand, we show that this truth-theoretical equivalence is not preserved by some other variants of and , arguing that the variants are more adequate axiomatisations of the fixed-point semantics than the corresponding variants.
Exogenous stromal cell-derived factor-1 (SDF-1) suppresses the NLRP3 inflammasome and inhibits pyroptosis in synoviocytes from osteoarthritic joints via activation of the AMPK signaling pathway
Authors: Wang Shuya , Mobasheri Ali , Zhang Yue , Wang Yanli , Dai Tianqi , Zhang Zhiyi 
Published: June 2021

Abstract
Objective
NLRP3 inflammasome may play a key role in OA pathogenesis. Stromal cell-derived factor-1 (SDF-1) is a homeostatic CXC chemokine. Since the role of SDF-1 in OA has not been explored, this study aimed to examine the effect of SDF-1 on NLRP3 inflammasome and pyroptosis in synoviocytes from OA joints.

Materials and methods
Human synovium was obtained from OA patients for isolation of primary synoviocytes and a murine model of collagenase-induced OA was established for testing intra-articular injections of SDF-1. Immunoblotting assays were used to examine the effects and underlying mechanism of action of SDF-1 on NLRP3 inflammasome and synoviocyte pyroptosis in synoviocytes. Inhibitors of AMPK and PI3K–mTOR were utilized to investigate the key signaling pathways involved in SDF-1-mediated OA inflammasome formation and pyroptosis.

Results
Synoviocytes from OA joints exhibited significantly higher expression of NLRP3 inflammasome and biomarkers of synoviocyte pyroptosis relative to healthy individuals. This was confirmed in the collagenase-induced OA model, where OA synoviocytes had a significantly lower SDF-1 expression than healthy ones. SDF-1 treatment in synoviocytes of OA patients and collagenase-induced OA led to significant downregulation in the expression of NLRP3 inflammasome and synoviocyte pyroptosis biomarkers. Inhibition of the AMPK signaling pathway significantly suppressed the inhibitory effect of SDF-1 on NLRP3 inflammasome expression of OA synoviocytes. However, blocking the SDF-1-activated PI3K–mTOR signaling pathway could still suppress the expression of NLRP3 inflammasome and synoviocyte pyroptosis biomarkers.

Conclusions
SDF-1 ameliorates NLRP3 inflammasome and pyroptosis in OA synoviocytes through activation of the AMPK signaling pathway. Therefore, SDF-1 may be a novel therapeutic target for OA.
Exploring aromatic cage flexibility of the histone methyllysine reader protein Spindlin1 and its impact on binding mode prediction: an in silico study
Authors: Luise Chiara , Robaa Dina , Sippl Wolfgang 
Published: June 2021

AbstractSome of the main challenges faced in drug discovery are pocket flexibility and binding mode prediction. In this work, we explored the aromatic cage flexibility of the histone methyllysine reader protein Spindlin1 and its impact on binding mode prediction by means of in silico approaches. We first investigated the Spindlin1 aromatic cage plasticity by analyzing the available crystal structures and through molecular dynamic simulations. Then we assessed the ability of rigid docking and flexible docking to rightly reproduce the binding mode of a known ligand into Spindlin1, as an example of a reader protein displaying flexibility in the binding pocket. The ability of induced fit docking was further probed to test if the right ligand binding mode could be obtained through flexible docking regardless of the initial protein conformation. Finally, the stability of generated docking poses was verified by molecular dynamic simulations. Accurate binding mode prediction was obtained showing that the herein reported approach is a highly promising combination of in silico methods able to rightly predict the binding mode of small molecule ligands in flexible binding pockets, such as those observed in some reader proteins.
Fans, Crimes and Misdemeanors: Fandom and the Ethics of Love
Authors: Archer Alfred 
Published: June 2021

AbstractIs it permissible to be a fan of an artist or a sports team that has behaved immorally? While this issue has recently been the subject of widespread public debate, it has received little attention in the philosophical literature. This paper will investigate this issue by examining the nature and ethics of fandom. I will argue that the crimes and misdemeanors of the object of fandom provide three kinds of moral reasons for fans to abandon their fandom. First, being a fan of the immoral may provide support for their immoral behavior. Second, fandom alters our perception in ways that will often lead us to be fail to perceive our idol’s faults and even to adopting immoral points of view in order to be able to maintain the positive view we have of them. Third, fandom, like friendship, may lead us to engage in acts of loyalty to protect the interests of our idols. This gives fans of the immoral good reason to abandon their fandom. However, these reasons will not always be conclusive and, in some cases, it may be possible to instead adopt a critical form of fandom.
A High Order Accurate Finite Difference Method for the Drinfel’d–Sokolov–Wilson Equation
Authors: Lindeberg Ludvig , Dao Tuan , Mattsson Ken 
Published: June 2021

AbstractWe analyse numerically the periodic problem and the initial boundary value problem of the Korteweg-de Vries equation and the Drindfeld–Sokolov–Wilson equation using the summation-by-parts simultaneous-approximation-term method. Two sets of boundary conditions are derived for each equation of which stability is shown using the energy method. Numerical analysis is done when the solution interacts with the boundaries. Results show the benefit of higher order SBP operators.
Reconstructing the slip velocities of the 1202 and 1759 CE earthquakes based on faulted archaeological structures at Tell Ateret, Dead Sea Fault
Authors: Schweppe Gregor , Hinzen Klaus-G. , Reamer Sharon K. , Marco Shmuel 
Published: June 2021

AbstractArchaeological structures built across active faults and ruptured by earthquakes have been used as markers to measure the amount of displacement caused by ground motion and thus to estimate the magnitude of ancient earthquakes. The example used in this study is the Crusader fortress at Tel Ateret (Vadum Iacob) in the Jordan Gorge, north of the Sea of Galilee, a site which has been ruptured repeatedly since the Iron Age. We use detailed laser scans and discrete element models of the fortification walls to deduce the slip velocity during the earthquake. Further, we test whether the in-situ observed deformation pattern of the walls allows quantification of the amount both sides of the fault moved and whether post-seismic creep contributed to total displacement. The dynamic simulation of the reaction of the fortification wall to a variety of earthquake scenarios supports the hypothesis that the wall was ruptured by two earthquakes in 1202 and 1759 CE. For the first time, we can estimate the slip velocity during the earthquakes to 3 and 1 m/s for the two events, attribute the main motion to the Arabian plate with a mostly locked Sinai plate, and exclude significant creep contribution to the observed displacements of 1.25 and 0.5 m, respectively. Considering a minimum long-term slip rate at the site of 2.6 mm/year, there is a deficit of at least 1.6 m slip corresponding to a potential future magnitude 7.5 earthquake; if we assume ~5 mm/year geodetic rate, the deficit is even larger.
Mfge8 attenuates human gastric antrum smooth muscle contractions
Authors: Li Wen , Olseen Ashley , Xie Yeming , Alexandru Cristina , Outland Andrew , Herrera Angela F. , Syder Andrew J. , Wykosky Jill , Perrino Brian A. 
Published: June 2021

AbstractCoordinated gastric smooth muscle contraction is critical for proper digestion and is adversely affected by a number of gastric motility disorders. In this study we report that the secreted protein Mfge8 (milk fat globule-EGF factor 8) inhibits the contractile responses of human gastric antrum muscles to cholinergic stimuli by reducing the inhibitory phosphorylation of the MYPT1 (myosin phosphatase-targeting subunit (1) subunit of MLCP (myosin light chain phosphatase), resulting in reduced LC20 (smooth muscle myosin regulatory light chain (2) phosphorylation. Mfge8 reduced the agonist-induced increase in the F-actin/G-actin ratios of β-actin and γ-actin1. We show that endogenous Mfge8 is bound to its receptor, α8β1 integrin, in human gastric antrum muscles, suggesting that human gastric antrum muscle mechanical responses are regulated by Mfge8. The regulation of gastric antrum smooth muscles by Mfge8 and α8 integrin functions as a brake on gastric antrum mechanical activities. Further studies of the role of Mfge8 and α8 integrin in regulating gastric antrum function will likely reveal additional novel aspects of gastric smooth muscle motility mechanisms.