bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crustal and Upper‐Mantle Structure Below Central and Southern Mexico
Authors: Espindola‐Carmona A. , Peter Daniel , Ortiz‐Aleman C. 
Published: June 2021

AbstractThe Mexican subduction zone is a complex convergent margin characterized by a slab with an unusual morphology, an abnormal location of the volcanic arc, and the existence of slow earthquakes (slow slip events and tectonic tremors). The number of seismic imaging studies of the Mexican subduction zone has increased over the past decade. These studies have revealed the seismic wave velocity structure beneath Central and Southern Mexico. However, the existing tomographic models are either confined to specific areas or have coarse resolution. As a consequence, they do not capture the lateral and finer‐scale variations in the mantle and the crust structure. Here, we fit frequency‐dependent traveltime differences between observed and synthetic seismograms in a three‐dimensional model of Central and Southern Mexico to constrain crustal and upper mantle seismic velocity structures jointly. We use ∼3,300 seismic records, filtered between 5 and 50 s, from 74 regional earthquakes. We perform point spread function tests to assess the resolution and trade‐offs between model parameters. Our tomographic model reveals several seismic wave velocity features. These features include the geometry of the Cocos slab, the partial melting zone beneath the Trans‐Mexican Volcanic Belt, and the Yucatan slab diving below Los Tuxtlas Volcanic Field that are consistent with previous studies. We also identify horizontal structures in the lower crust and the shallow upper mantle that were not previously identified. These structures include slow seismic wave velocity anomalies that may be correlated with ultraslow seismic velocity zones and high conductivity regions, where slow earthquakes have been identified.
Reaction Mechanism and Water/Rock Ratios Involved in Epidosite Alteration of the Oceanic Crust
Authors: Weber Samuel , Diamond Larryn W. , Alt‐Epping Peter , Brett‐Adams Alannah C. 
Published: June 2021

AbstractEpidosites are a prominent type of subseafloor hydrothermal alteration of basalts in ophiolites and greenstone belts, showing an end‐member mineral assemblage of epidote + quartz + titanite + Fe‐oxide. Epidosites are known to form within crustal‐scale upflow zones and their fluids have been proposed as deep equivalents of black‐smoker seafloor vent fluids. Proposals of the mass of fluid per mass of rock (W/R ratio) needed to form epidosites are contradictory, varying from 20 (Sr isotopes) to > 1,000 (Mg mobility). To test these proposals we have conducted a petrographic, geochemical and reactive‐transport numerical simulation study of the chemical reaction that generates km3‐size epidosite zones within the lavas and sheeted dike complex of the Samail ophiolite, Oman. At 250–400°C the modeled epidosite‐forming fluid has near‐neutral pH (∼ 5.2), high fO2, low sulfur and very low Fe (10−6 mol/kg) contents. These features argue against a genetic link with black‐smoker fluids. Chemical buffering by the epidosite fluid enriches the precursor spilites in Ca and depletes them in Na and Mg. Completion of the spilite‐to‐epidosite reaction requires enormous W/R ratios of 700–∼40,000, depending on initial Mg content and temperature. Collectively, the variably altered rocks in the Samail epidosite zones record flow of ∼1015 kg of fluid through each km3 of precursor spilite rock. This fluid imposed on the epidosite an Sr‐isotope signature inherited from the previous rock‐buffered chemical evolution of the fluid through the oceanic crust, thereby explaining the apparently contradictory low W/R ratios based on Sr isotopes.
Drought Risk of Global Terrestrial Gross Primary Productivity Over the Last 40 Years Detected by a Remote Sensing‐Driven Process Model
Authors: He Qiaoning , Ju Weimin , Dai Shengpei , He Wei , Song Lian , Wang Songhan , Li Xinchuan , Mao Guangxiong 
Published: June 2021

AbstractGross primary productivity (GPP) is the largest flux in the global terrestrial carbon cycle. Drought has significantly impacted global terrestrial GPP in recent decades, and has been projected to occur with increasing frequency and intensity. However, the drought risk of global terrestrial GPP has not been well investigated. In this study, global terrestrial GPP during 1981–2016 was simulated with the process‐based Boreal Ecosystem Productivity Simulator model. Then, the drought risk of GPP was quantified as the product of drought probability and reduction of GPP caused by drought, which was determined using the standardized precipitation evapotranspiration index. During the study period, the drought risk of GPP was high in the southeastern United States, most of South America, southern Europe, central and eastern Africa, eastern and southeastern Asia, and eastern Australia. It was low at some high latitudes of the Northern Hemisphere and in part of tropical South America, where terrestrial GPP increased slightly in drought years. The drought risk of terrestrial GPP was greater during 2000–2016 than during 1981–1999 in 21 out of 24 climatic zones. The global mean drought risk of GPP increased from 13.6 g C m−2 yr−1 during 1981–1999 to 19.3 g C m−2 yr−1 during 2000–2016. The increase in drought risk of GPP was mainly caused by the increase in drought vulnerability. Simulation experiments indicated that the drought vulnerability of GPP was mainly induced by climatic variability. This study advances our understanding on the impact of drought on GPP over the globe.
Exploring the Boundaries of Microbial Habitability in Soil
Authors: Dragone Nicholas B. , Diaz Melisa A. , Hogg Ian D. , Lyons W. Berry , Jackson W. Andrew , Wall Diana H. , Adams Byron J. , Fierer Noah 
Published: June 2021

AbstractMicrobes are widely assumed to be capable of colonizing even the most challenging terrestrial surface environments on Earth given enough time. We would not expect to find surface soils uninhabited by microbes as soils typically harbor diverse microbial communities and viable microbes have been detected in soils exposed to even the most inhospitable conditions. However, if uninhabited soils do exist, we might expect to find them in Antarctica. We analyzed 204 ice‐free soils collected from across a remote valley in the Transantarctic Mountains (84–85°S, 174–177°W) and were able to identify a potential limit of microbial habitability. While most of the soils we tested contained diverse microbial communities, with fungi being particularly ubiquitous, microbes could not be detected in many of the driest, higher elevation soils—results that were confirmed using cultivation‐dependent, cultivation‐independent, and metabolic assays. While we cannot confirm that this subset of soils is completely sterile and devoid of microbial life, our results suggest that microbial life is severely restricted in the coldest, driest, and saltiest Antarctic soils. Constant exposure to these conditions for thousands of years has limited microbial communities so that their presence and activity is below detectable limits using a variety of standard methods. Such soils are unlikely to be unique to the studied region with this work supporting previous hypotheses that microbial habitability is constrained by near‐continuous exposure to cold, dry, and salty conditions, establishing the environmental conditions that limit microbial life in terrestrial surface soils.
The Implementation of Framework for Improvement by Vertical Enhancement Into Energy Exascale Earth System Model
Authors: Lee Hsiang‐He , Bogenschutz Peter , Yamaguchi Takanobu 
Published: June 2021

AbstractThe low cloud bias in global climate models (GCMs) remains an unsolved problem. Coarse vertical resolution in GCMs has been suggested to be a significant cause of low cloud bias because planetary boundary layer parameterizations cannot resolve sharp temperature and moisture gradients often found at the top of subtropical stratocumulus layers. This work aims to ameliorate the low cloud problem by implementing a new computational method, the Framework for Improvement by Vertical Enhancement (FIVE), into the Energy Exascale Earth System Model (E3SM). Three physics schemes representing microphysics, radiation, and turbulence as well as vertical advection are interfaced to vertically enhanced physics (VEP), which allows for these processes to be computed on a higher vertical resolution grid compared to the rest of the E3SM model. We demonstrate the better representation of subtropical boundary layer clouds with FIVE while limiting additional computational cost from the increased number of levels. When the vertical resolution approaches the large eddy simulation‐like vertical resolution in VEP, the climatological low cloud amount shows a significant increase of more than 30% in the southeastern Pacific Ocean. Using FIVE to improve the representation of low‐level clouds does not come with any negative side effects associated with the simulation of mid‐ and high‐level cloud and precipitation, that can occur when running the full model at higher vertical resolution.
Porosity‐Permeability Evolution During Simultaneous Mineral Dissolution and Precipitation
Authors: Sabo Mollie S. , Beckingham Lauren E. 
Published: June 2021

AbstractPermeability in reactive porous media evolves in complex ways that are hard to predict. Macroscopic empirical equations are often used to estimate permeability evolution but fail to reflect the impact of pore scale reactions on permeability. This work aims to understand the evolution of permeability in systems where mineral dissolution and precipitation occur simultaneously. Pore network models are used for permeability simulation of a Paluxy sandstone using pore and pore‐throat size distributions from the analysis of X‐ray CT images. Pore and pore‐throat radii are increased and decreased to reflect the effects of dissolution and precipitation reactions. Varying spatial distributions of reactions are simulated and the resulting porosity and permeability values compared with commonly used macroscopic equations. It is observed that when dissolution occurs at the inlet and precipitation at the outlet, porosity increases while permeability decreases. Similar results are also observed in the respective opposite scenario where precipitation occurs at the inlet and dissolution at the outlet. When dissolution and precipitation reactions are randomly distributed throughout the network, porosity increases with little change in permeability that is not captured by the empirical equations. When reactions are controlled by pore and pore‐throat sizes, such as dissolution occurring in pores and pore‐throats of small size and precipitation in pores and pore‐throats of larger size, porosity and permeability decrease. When precipitation occurs in pores and pore‐throats of smaller size and dissolution in pores and pore‐throats of larger size, porosity and permeability increase and is described relatively well by the Verma‐Pruess porosity‐permeability equation.
Exploring GPS Observations of Postseismic Deformation Following the 2012 MW7.8 Haida Gwaii and 2013 MW7.5 Craig, Alaska Earthquakes: Implications for Viscoelastic Earth Structure
Authors: Guns K. A. , Pollitz F. F. , Lay T. , Yue H. 
Published: June 2021

AbstractThe Queen Charlotte‐Fairweather Fault (QC‐FF) system off the coast of British Columbia and southeast Alaska is a highly active dextral strike‐slip plate boundary that accommodates ∼50 mm/yr of relative motion between the Pacific and North America plates. Nine MW ≥ 6.7 earthquakes have occurred along the QC‐FF system since 1910, including a MS(G‐R)8.1 event in 1949. Two recent earthquakes, the October 28, 2012 Haida Gwaii (MW7.8) and January 5, 2013 Craig, Alaska (MW7.5) events, produced postseismic transient deformation that was recorded in the motions of 25 nearby continuous Global Positioning System (cGPS) stations. Here, we use 5+ yr of cGPS measurements to characterize the underlying mechanisms of postseismic deformation and to constrain the viscosity structure of the upper mantle surrounding the QC‐FF. We construct forward models of viscoelastic deformation driven by coseismic stress changes from these two earthquakes and explore a large set of laterally heterogeneous viscosity structures that incorporate a relatively weak back‐arc domain; we then evaluate each model based on its fit to the postseismic signals in our cGPS data. In determining best‐fit model structures, we additionally incorporate the effects of afterslip following the 2012 event. Our results indicate the occurrence of a combination of temporally decaying afterslip and vigorous viscoelastic relaxation of the mantle asthenosphere. In addition, our best‐fit viscosity structure (transient viscosity of 1.4–2.0 × 1018 Pa s; steady‐state viscosity of 1019 Pa s) is consistent with the range of upper mantle viscosities determined in previous studies of glacial isostatic rebound and postseismic deformation.
Changing Spatial Patterns of Deep Convection in the Subpolar North Atlantic
Authors: Rühs Siren , Oliver Eric C. J. , Biastoch Arne , Böning Claus W. , Dowd Michael , Getzlaff Klaus , Martin Torge , Myers Paul G. 
Published: June 2021

AbstractDeep convection and associated deep water formation are key processes for climate variability, since they impact the oceanic uptake of heat and trace gases and alter the structure and strength of the global overturning circulation. For long, deep convection in the subpolar North Atlantic was thought to be confined to the central Labrador Sea in the western subpolar gyre (SPG). However, there is increasing observational evidence that deep convection also has occurred in the eastern SPG south of Cape Farewell and in the Irminger Sea, in particular, in 2015–2018. Here we assess this recent event in the context of the temporal evolution of spatial deep convection patterns in the SPG since the mid‐twentieth century, using realistic eddy‐rich ocean model simulations. These reveal a large interannual variability with changing contributions of the eastern SPG to the total deep convection volume. Notably, in the late 1980s to early 1990s, the period with highest deep convection intensity in the Labrador Sea related to a persistent positive phase of the North Atlantic Oscillation, the relative contribution of the eastern SPG was small. In contrast, in 2015–2018, deep convection occurred with an unprecedented large relative contribution of the eastern SPG. This is partly linked to a smaller north‐westward extent of deep convection in the Labrador Sea compared to previous periods of intensified deep convection, and may be a first fingerprint of freshening trends in the Labrador Sea potentially associated with enhanced Greenland melting and the oceanic advection of the 2012–2016 eastern North Atlantic fresh anomaly.
A Discrete‐Domain Approach to Three‐Phase Hysteresis in Porous Media
Authors: Helland Johan Olav , Jettestuen Espen , Friis Helmer André 
Published: June 2021

AbstractWe present a discrete‐domain approach to three‐phase displacements and hysteresis in porous media. In this method, constrained energy minimization leads to evolution equations for local saturations that describe a wide range of three‐phase displacements, including pressure‐ and saturation‐controlled displacement with or without preservation of one of the defending phases. Under action of global saturation constraints, irreversible displacements lead to significant fluid redistribution, as well as abrupt fluctuations of both the three‐phase saturation paths and the corresponding capillary pressures. These features are a consequence of Haines jumps with cooperative behavior that occur at pore scale in three‐phase systems. The method is a fast and convenient way to investigate hysteresis behavior of three‐phase displacement in porous media. As free energy is an extensive property, the framework links pore and core scales and provide a means to achieve upscaled three‐phase displacements for higher‐order hysteresis loops, which rarely is obtained in time‐consuming three‐phase measurements or pore‐scale simulations.
Extended-release naltrexone/bupropion is safe and effective among subjects with type 2 diabetes already taking incretin agents: a post-hoc analysis of the LIGHT trial
Authors: Wharton Sean , Yin Peter , Burrows Melonie , Gould Errol , Blavignac Jessica , Christensen Rebecca A. G. , Kamran Elham , Camacho Fernando , Barakat Maxime 
Published: June 2021

Abstract
Background
Extended-release naltrexone/bupropion (NB) is indicated for chronic weight management. Incretin agents are recommended for patients with type 2 diabetes. This analysis looked at the add-on of NB to incretins to see if weight loss could occur in patients already stabilized on incretin agents.

Methods
This was a post-hoc analysis of NB vs. placebo (PL) among subjects with type 2 diabetes stable on an incretin agent prior to randomization in a double-blind, PL-controlled cardiovascular outcome trial (N = 1317).

Results
Over 1 year, mean weight loss was significantly greater among NB patients vs. PL among those taking DPP-4i (mean absolute difference 4.6% [p < 0.0001]) and those taking GLP-1RAs (mean absolute difference 5.2%, p < 0.0001). Proportions of subjects achieving 5% weight loss were significantly greater for NB vs. PL at weeks 26 and 52 among those taking DPP-4is or GLP-1RAs. There were no significant differences in effectiveness observed between NB + DPP-4i and NB + GLP-1RA or between PL + DPP-4i and PL + GLP-1RA in any of the analyses. Serious adverse events were reported by 9.1% and 11.1% for PL + DPP-4i and PL + GLP-1RA, respectively, and 13.3% and 12.4% of NB + DPP-4i and NB + GLP-1RA, respectively.

Conclusion
NB appears to be effective in reducing weight in patients with T2DM and obesity/overweight who are taking DPP-4ihibitors or GLP-1RA. The SAE rates in all arms of this analysis were lower than have been reported in other cardiovascular outcome trials in type 2 diabetes.
Top-emitting thermally activated delayed fluorescence organic light-emitting devices with weak light-matter coupling
Authors: Zang Chunxiu , Liu Shihao , Xu Mengxin , Wang Ruifang , Cao Chen , Zhu Zelin , Zhang Jiaming , Wang Hui , Zhang Letian , Xie Wenfa , Lee Chun-Sing 
Published: June 2021

AbstractResonance interaction between a molecular transition and a confined electromagnetic field can lead to weak or strong light-matter coupling. Considering the substantial exciton–phonon coupling in thermally activated delayed fluorescence (TADF) materials, it is thus interesting to explore whether weak light-matter coupling can be used to redistribute optical density of states and to change the rate of radiative decay. Here, we demonstrate that the emission distribution of TADF emitters can be reshaped and narrowed in a top-emitting organic light-emitting device (OLED) with a weakly coupled microcavity. The Purcell effect of weak microcavity is found to be different for TADF emitters with different molecular orientations. We demonstrate that radiative rates of the TADF emitters with vertical orientation can be substantial increased in weakly coupled organic microcavity. These observations can enhance external quantum efficiencies, reduce efficiency roll-off, and improve color-purities of TADF OLEDs, especially for emitters without highly horizontal orientation.
Genetic risk of clozapine-induced leukopenia and neutropenia: a genome-wide association study
Authors: Chen Jianhua , Yang Ping , Zhang Qian , Chen Ruirui , Wang Peng , Liu Benxiu , Sun Wensheng , Jian Xuemin , Xiang Siying , Zhou Juan , Li Ningning , Wang Ke , Gao Chengwen , Wen Yanqin , Wu Chuanhong , Zhang Jinmai , Zhao Yalin , Yang Qiangzhen , Li Meihang , Stewart Robert , Sun Yuanchao , Pan Dun , Niu Yujuan , Wang Zhuo , Xu Yifeng , Li Xingwang , He Lin , Li Zhiqiang , Shi Yongyong 
Published: June 2021

Abstract
Background
Clozapine is considered to be the most effective antipsychotic medication for schizophrenia. However, it is associated with several adverse effects such as leukopenia, and the underlying mechanism has not yet been fully elucidated. The authors performed a genome-wide association study (GWAS) in a Chinese population to identify genetic markers for clozapine-induced leukopenia (CIL) and clozapine-induced neutropenia (CIN).

Methods
A total of 1879 patients (225 CIL cases, including 43 CIN cases, and 1,654 controls) of Chinese descent were included. Data from common and rare single nucleotide polymorphisms (SNPs) were tested for association. The authors also performed a trans-ancestry meta-analysis with GWAS results of European individuals from the Clozapine-Induced Agranulocytosis Consortium (CIAC).

Results
The authors identified several novel loci reaching the threshold of genome-wide significance level (P < 5 × 10−8). Three novel loci were associated with CIL while six were associated with CIN, and two T cell related genes (TRAC and TRAT1) were implicated. The authors also observed that one locus with evidence close to genome-wide significance (P = 5.08 × 10−8) was near the HLA-B gene in the major histocompatibility complex region in the trans-ancestry meta-analysis.

Conclusions
The associations provide novel and valuable understanding of the genetic and immune causes of CIL and CIN, which is useful for improving clinical management of clozapine related treatment for schizophrenia. Causal variants and related underlying molecular mechanisms need to be understood in future developments.
IL-37b alleviates endothelial cell apoptosis and inflammation in Kawasaki disease through IL-1R8 pathway
Authors: Jia Chang , Zhuge Yingzhi , Zhang Shuchi , Ni Chao , Wang Linlin , Wu Rongzhou , Niu Chao , Wen Zhengwang , Rong Xing , Qiu Huixian , Chu Maoping 
Published: June 2021

AbstractKawasaki disease (KD) is an acute vasculitis of pediatric populations that may develop coronary artery aneurysms if untreated. It has been regarded as the principal cause of acquired heart disease in children of the developed countries. Interleukin (IL)-37, as one of the IL-1 family members, is a natural suppressor of inflammation that is caused by activation of innate and adaptive immunity. However, detailed roles of IL-37 in KD are largely unclear. Sera from patients with KD displayed that IL-37 level was significantly decreased compared with healthy controls (HCs). QRT-PCR and western blot analyses showed that the expression level of IL-37 variant, IL-37b, was remarkably downregulated in human umbilical vein endothelial cells (HUVECs) exposed to KD sera-treated THP1 cells. Therefore, we researched the role of IL-37b in the context of KD and hypothesized that IL-37b may have a powerful protective effect in KD patients. We first observed and substantiated the protective role of IL-37b in a mouse model of KD induced by Candida albicans cell wall extracts (CAWS). In vitro experiments demonstrated that IL-37b alleviated endothelial cell apoptosis and inflammation via IL-1R8 receptor by inhibiting ERK and NFκB activation, which were also recapitulated in the KD mouse model. Together, our findings suggest that IL-37b play an effective protective role in coronary endothelial damage in KD, providing new evidence that IL-37b is a potential candidate drug to treat KD.