bluuebunny/crossref_metadata_2025_split huggingface dataset:
Event-Triggered Fixed-time Adaptive Fuzzy Control for State-constrained Stochastic Nonlinear Systems Without Feasibility Conditions
Authors: Yao Yangang , Tan Jieqing , Wu Jian , Zhang Xu 
Published: March 2021

Abstract
The problem of event-triggered fixed-time control for state-constrained stochastic nonlinear systems is discussed in this article. Different from the Barrier Lyapunov Function (BLF)-based and Integral BLF-based schemes which rely on feasibility conditions (FCs), by introducing nonlinear state-dependent functions , the asymmetric time-varying state constraints are handled without FCs .Combining with the fixed-time stable theory and dynamic surface control technique with fixed-time filter, the fixed-time stability in probability of the closed-loop system is ensured and the problems of “explosion of complexity” and “singularity” are overcome. Furthermore, the novel fixed-time error compensation signals are designed to compensate filtering errors, and event-triggered control technique is used to save network resources. Simulations also illustrate the effectiveness of the proposed method.
Tip60 Might Be a Candidate For The Acetylation of Hepatic Carbonic Anhydrase I and III in Mice
Authors: BALTACI Nurdan GONUL , KOCPINAR Enver Fehim , Budak Harun 
Published: March 2021

Abstract
Carbonic anhydrases (CAs) play an important role in maintaining pH balance by catalyzing the conversion of carbon dioxide to bicarbonate. Since this pH balance is critical to health, all organisms must develop mechanisms to control and regulate it. Although there is a great deal of literature on the biochemical, functional, and structural properties of the CA family, there is no enough knowledge on the regulation of CAs at gene and protein levels, especially their epigenetic regulation. In this study, impact of Tip60, a member of histone acetyltransferases family, on the expression of Ca1 and Ca3 genes in liver tissue was investigated at different zeitgeber time points in control and liver-specific Tip60 knockout mice (mutant) groups. First of all, Tip60 was specifically knocked out in mouse liver the using Cre/loxP system and knockout rate was shown as 83% - 88% by southern blot. Expression profiles of Ca1 and Ca3 genes in both groups were determined by Real-Time PCR at six different time points. While Ca1 showed the highest expression at ZT8 and ZT12, the lowest expression profile was observed at ZT0 and ZT20. Hepatic Ca1 showed a robust circadian expression. While hepatic Ca3 showed almost the same level of expression at different time units. The expression of Ca1 and Ca3 significantly decreased in the absence of Tip60 in mouse liver all time period. In conclusion, it was suggested for the first time that Tip60 may be considered a candidate protein in the regulation of Ca1 and Ca3 genes, possibly by acetylation.
Fasudil Attenuates Adriamycin-Induced Cardiac Damage by Modifying Oxidative Stress and Apoptosis Mediated Cellular Signaling
Authors: Yan Yi , Xiang Chengyu , Zhang Dingguo 
Published: March 2021

Abstract
PURPOSETo explore the protective mechanism of fasudil,a Rho kinase inhibitor, on acute cardiac injury induced by adriamycin(ADR).METHODSIn vitro investigations on H9C2 cell line, as well as an in vivo study in a mouse model of ADR-induced acute cardiomyopathy, were performed. In vitro, H9C2 cells were treated with fasudil for 30mins then incubated with ADR for 24 hours. Cells were collected for immunohistochemistry and western blot study, respectively. In vivo, C57BL6 mice were randomly divided into the following four groups: ①ADR group;②low-dose fasudil ( ADR+L);③high-dose fasudil ( ADR+H); and ④control group(CON). Animals were injected i.p 20 mg/kg ADR once in group①~③. And animals were injected i.p fasudil (2 or 10 mg/kg/day ) daily once for six times in group ②and ③,respectively. Blood samples and heart tissues were collected for assays.RESULTSIn vitro, fasudil treatment ameliorated ADR-induced immunofluorescence reaction of 8-OHdG, decreased the expression of TUNEL cells and protein of Bax、Caspase-3 and p53,and increased the expression of protein of Bcl-2 and SIRT 1. In the mouse model, administration of fasudil significantly ameliorated ADR-induced cardiac damage, suppressed cell apoptosis and senescence, ameliorated redox imbalance and DNA damage.CONCLUSIONFasudil has the protective effect on adriamycin induced acute cardiotoxicity, which partially attributed to its antioxidant, anti-senescence, and anti-apoptotic effects of inhibiting the RhoA/Rho kinase signaling pathway.
Trends and Patterns in the Economic History of the Energy Complex
Authors: Shakhovskaya Larisa S. , Timonina Victoria I. 
Published: March 2021

Abstract
The age-old history of capitalist countries includes the fact that many of these metropolitan countries, which, unlike their colonies, were producers, used various methods to gain global control over energy resources, as they were concentrated in the colonies. Control over strategic resources allows control over the national economy of any country as a whole. The article describes a broad-scale conflict in which resource dependence is directly proportional to the intensity of social production required for the effective functioning of the national economy as a whole.
Levels of selected pesticides and trophic transfer of DDTs through the aquatic food web in the Lake Ziway ecosystem
Authors: Mergia Mekuria Teshome , Weldemariam Ermias , Eklo Ole , Yimer Girma 
Published: March 2021

Abstract
The levels of 27 selected pesticides and trophic biomagnification of DDT were investigated in biota samples of the Lake Ziway in the Rift valley region, Ethiopia. Pesticide residues were analyzed using gas chromatography coupled with mass spectrometry (GC MS). Carbon source and trophic position were calculated by using 13C and 15N stable isotopes, individually, and trophic magnification factors (TMFs) were inferred. Among pesticides analyzed, only DDT and its metabolites (o,pʹ-DDD, o,pʹ-DDE, p,pʹ-DDD, and p,pʹ-DDE) were quantified in biota samples. The most prominent metabolite was p,pʹ-DDE with mean concentration ranging from the 0.22-7.7ngg− 1 wet weight. Moreover, the ratio of DDT/DDD + DDE in all the biota samples was less than 1 signifying historical DDT application. The trophic magnification factor (TMF) for p,pʹ-DDE, and ΣDDT were 1.18 and 1.19 respectively. Regression of log [ΣDDT] vs TL (trophic level) among all biota species showed a significant correlation, indicating that DDTs are biomagnifying along with the food web of Lake Ziway. The concentrations of DDTs and other organochlorine pesticides found in biota from Lake Ziway were, in general, lower than studies found in previous studies carried out in the same lake.
In-situ Deposition of Ag Nanoparticles on Dopamine Pre-Modified Cotton Fabric and Analysis of Its Functional Mechanical and Dyeing Properties
Authors: Tania Imana , Ali Mohammad , Azam Md. Shafiul 
Published: March 2021

Abstract
This study investigates the potentiality of Ag nanoparticles for the preparation of value-added and improved functional textiles. It demonstrates the in-situ deposition of Ag nanoparticles on cotton fabric pre-functionalized by dopamine hydrochloride. Surface characterization of nano-Ag deposited fabric is done by SEM (scanning electron microscope) and EDS (energy dispersive spectroscopy) that confirms the shape and deposition of a higher amount of nano-Ag particles. The crystalline size and approximate shape are determined by X-ray diffraction spectroscopy. The results reveal that the nano-Ag deposition brings excellent performance on functional properties of cotton fabric. Antimicrobial activity is found as 82.60% reduction against S.aureus and 92% against E.coli measured by bacterial reduction rate (R%). The fabric also shows good UV protection power and admirable crease resistance. The fabric has also been dyed with reactive dyestuff and enhanced dyeing performance is found due to nano-Ag deposition. However, nano deposition causes a slight change in some important mechanical properties.
Primary treatment and Recent survival trends in patients with Primary Diffuse Large B-Cell Lymphoma of Central Nervous System,1995-2016: a population-based SEER analysis
Authors: Chen Cui , Sun Peng , Sun Xiaoqing , Chen Shaoyong , Yang Hang , Wang Yu , Li Zhiming 
Published: March 2021

Abstract
Purpose

This retrospective cohort study aimed to evaluate primary treatment and recent survival trends in patients with primary diffuse large B-cell lymphoma of CNS from 1995 to 2016.
Methods

Using the SEER data, patients diagnosed with non-HIV associated PCNSL-DLBCL aged ⩾18 years between 1995 and 2016 were identified. The year of diagnosis was divided into the time periods-1(1995–2002), the time periods-2(2003–2012) and the time periods-3(2013–2016). We used Chi-square tests, the Kaplan–Meier method, log-rank test and Cox regression model in the analysis.
Results

Overall, 3760 patients were included. Both the use of radiotherapy alone and the application of combined chemoradiotherapy decreased significantly, following the wider use of chemotherapy alone during 1995–2016. There was a significant improvement in PCNSL cancer-specific survival (period-1: 13 months vs period-2: 19 months vs period-3: 41 months, P < 0.001). Survival of patients aged above 70 years did not change from the time period-1 to the time period-2 (P = 0.101). However, there was an increase in CSS from the time period-2 to the time period-3 in the elderly patients (period-2: 5 months vs period-3: 9 months, P < 0.001). On multivariable analyses, diagnosed in the time period-3 was significantly and independently associated with better CSS (HR 0.577, 95% CI 0.506–0.659).
Conclusions

Our analysis shows the use of radiotherapy in the treatment of PCNSL has waned over the study span. There was a significant improvement in CSS during 1995–2016, which reflected developments in treatment over time. The elderly patient population also gained a significant CSS benefit in the most recent period.
Tissue-based metabolomics profiling reveals metabolic signatures and major metabolic pathways of gastric cancer
Authors: Wang Yaqin , Chen Wenchao , Li Kun , Wu Gang , Zhang Wei , Ma Peizhi 
Published: March 2021

Abstract
Purpose

This study was aimed to screen differential metabolites between gastric cancer (GC) and paracancerous (PC) tissues and find new biomarkers of GC.
Methods

GC (n = 28) and matched PC (n = 28) tissues were collected and LC-MS/MS analyses were performed to detect metabolites of GC and PC tissues in positive and negative models. Principal component analysis (PCA) and orthogonal projections to latent structures-discriminate analysis (OPLS-DA) were conducted to describe distribution of origin data and general separation and estimate the robustness and the predictive ability of our mode. Differential metabolites were screened based on criterion of variables with p value < 0.05 and VIP (variable importance in the projection) > 1.0. Receiver operating characteristic (ROC) analysis was performed to evaluate the diagnostic power of differential metabolites. Kyoto Encyclopedia of Genes and Genomes (KEGG) was performed to search for metabolite pathways and MetaboAnalyst was used for pathway enrichment analysis.
Results

Several metabolites were significantly changed in GC group compared with PC group. Thirteen metabolites with high VIP were chose and among which 1-methylnicotinamide, dodecanoic acid and sphinganine possessed high AUC values (AUC > 0.8) indicating an excellent discriminatory ability on GC. Pathways such as pentose phosphate pathway and histidine metabolism were focused based on differential metabolites demonstrating their effects on progress of GC.
Conclusions

In conclusion, we investigated the tissue-based metabolomics profile of GC and several differential metabolites and signaling pathways were focused. Further study is needed to verify those results.
WITHDRAWN: A facile synthesis of MgFe2O4/ZnS heterojunction with effectively enhanced visible light photocatalytic activity for degradation of methylene blue and crystal violet dyes
Authors: S Rajkumar , S Seetharaman , V Vijayan , M Sivaraj , M Chandran , R Saravanan 
Published: March 2021

Abstract
A novel n-MgFe2O4–n-ZnS heterojunction catalyst was employed via two step approach for photodegradation of organic dyes such as methylene blue (MB) and crystal violet (CV) dyes under visible light irradiation. The synthesized MgFe2O4/ZnS NCs were characterized using PXRD, FTIR, UV-visible spectroscopy, PL and FESEM analysis which reveals the formation of flake like structure with size as to be ~50 nm. The photocatalytic experimental result demonstrates that the MgFe2O4/ZnS nanocomposites (NCs) improve photodegradation performance with 98.0% and 91% decomposition of MB and CV dyes within 120 min illumination during simulated visible light irradiation. From the result, MgFe2O4/ZnS NCs has higher photocatalytic performance than that of MgFe2O4, and ZnS due to efficient separation of the photo-induced electron-hole pairs and effective electron–hole generation transfer by the formation of n-MgFe2O4–n-ZnS heterojunction. Hence, photodegradation performance implies that the synthesized MgFe2O4/ZnS NCs can be effectively utilized in waste water purification systems.
Tribology of High-performance PEEK-, PI-, and ATSP-based Self-lubricating Polymers Up to 300 oC
Authors: Bashandeh Kian , Lan Pixiang , Polycarpou Andreas A. 
Published: March 2021

Abstract
High-performance polymers (HPPs) with self-lubricating properties are promising materials for bearing and tribological components that demand low friction and low wear in the absence of liquid lubrication. This study reports on the tribological performance of three advanced HPPs, namely ATSP-, PEEK-, and PI-based polymer composites. The experiments were performed using pin-on-disk configuration under dry sliding conditions and different environmental temperatures from 25 (room temperature) to 300 °C. The role of temperature on the formation of polymer transfer films on the steel counterpart was investigated using microscopy and profilometric measurements, and correlations were made to their tribological performance. From the three tested composites, ATSP-based composite exhibited the best overall performance with low friction and low wear.
Clinical Significance of Intravesical Prostatic Protrusion Index in Patients with Clinical Diagnosis of Benign Prostatic Hyperplasia.
Authors: Yahyazadeh Seyed Reza , Izadi Seyed Shahaboddin 
Published: March 2021

Abstract
Purpose: To investigate the clinical significance of the intravesical prostatic protrusion (IPP) index in benign prostatic hyperplasia (BPH) patients to clarify its diagnostic value in predicting the clinical and structural abnormalities of the prostate. Materials and Methods: In this descriptive and analytical cross-sectional study, we include every man older than 50 years old with lower urinary tract symptoms (LUTS), predominantly voiding or obstructive, suggestive of BPH. The patients were evaluated to determine the following indices: IPSS (International Prostate Symptom Score) Index, QoL (quality of life), prostate volume (PV) and postvoid residual urine (PVR), serum PSA level, and the maximum urinary flow rate (Qmax) obtained by uroflowmetry. Subsequently, the assessment of the IPP index was undertaken by transabdominal ultrasonography. The categorization of the IPP index was done into 3 grades: grade one (below 5 mm), grade two (between 5 and 10 mm), and grade three (greater than 10 mm). Results: The significant direct correlation between the intravesical prostatic protrusion and international prostate symptom score, quality of life, prostate volume, postvoid residual urine, and serum PSA as well as inversely with the maximum urinary flow rate was confirmed both before and after the medical treatment. Also, the need for surgical intervention increased significantly with increasing IPP levels. Conclusion: The intravesical prostatic protrusion can be used to evaluate and predict the severity of symptoms and outcomes in patients with clinical BPH.
Expression Patterns of Microenvironmental Factors and Tenascin-C at the Invasive Front of Stage II And III Colorectal Cancer: Novel Tumor Prognostic Markers
Authors: Hashimoto Mai , Uesugi Noriyuki , Osaka Mitsumasa , Yanagawa Naoki , Otsuka Koki , Kajiwara Yoshiki , Ueno Hedeki , Sasaki Akira , Sugai Tamotsu 
Published: March 2021

Abstract
Background. Biological markers expressed in cancer cells and the surrounding cancer-associated fibroblasts (CAF) can be used for prediction of patient prognosis in colorectal cancer (CRC). Here, we used immunohistochemical techniques to evaluate cancer cells’ expression of specific biomarkers that are closely associated with neoplastic progression. Patients and Methods. Immunohistochemical markers included Ki-67, p53, β-catenin, MMP7, E-cadherin and HIF1-α. We also characterized microenvironmental markers expressed by CAF, including expression of α-smooth muscle actin, CD10, podoplanin, fibroblast specific protein 1, platelet derived growth factor β, fibroblast association protein, tenascin-C (TNC), ZEB1 and TWIST1. The study population consisted of 286 CRC patients with stage II and III disease. Stage II and III CRC were divided into a first and a second cohort (for validation). The CRCs were stratified using cluster analysis. To identify the utility of prognostic markers in stage II and III CRC, univariate and multivariate analyses were performed in both cohorts. Results. Stage II and III CRCs were stratified into 3 subgroups. Specific subgroups were significantly correlated to disease-free survival using univariate and multivariate analyses in the first cohort. High expression of TNC was identified as a single prognostic marker in both cohorts by univariate and multivariate analyses. Conclusions. We suggest that the presence of a specific subgroup defined by multiple markers can be used for prediction of CRC outcome in stages II and III. In addition, we showed that high expression of TNC was correlated with a poorer prognosis in stages II and III of CRC.
Obstructive Pneumonia With Bronchial Foreign Body: A Case Report
Authors: Tanaka Hitomi , Anno Takatoshi , Takenouchi Haruka , Kaneto Hideaki , Oga Toru , Okimoto Niro , Tomoda Koichi 
Published: March 2021

Abstract
Background: Bronchial foreign bodies are relatively uncommon in adults. There are a variety of symptoms induced by airway foreign bodies, although the typical symptoms of some bronchial foreign bodies are cough, wheezing, chest pain, hemoptysis and fever up. Case presentation: An 80-year-old Japanese man was referred to our hospital with symptom of 7-month history of cough and pneumonia. His chest radiograph showed a slight increase in opacity. His vital signs and his laboratory data were almost normal. Chest computed tomography revealed obstructive pneumonia and a bronchial foreign body. We performed bronchoscopy and detected a fish bone as an intrabronchial foreign body and finally removed it from the bronchi.Conclusions:It is very important to carefully perform medical consultation about the current and past medical history. People in some countries and regions such as Japan have a habit of eating fish. It is necessary to more carefully consider the possibility of some bronchial foreign body such as a fish bone, when we observe symptoms of persistent cough.
Post-Anesthesia Hookwire Localization of Pulmonary Ground Glass Nodules Guided by Computed-Tomography Three-Dimensional Reconstruction: A Feasibility Study
Authors: Wang Chong , Liu Yang , Xiao Bo , Liu Shuku 
Published: March 2021

Abstract
Background: Computed-tomography(CT) guided hookwire localization has disadvantages, such as pain, patient transport risk and increased radiation exposure. In order to overcome the above shortcomings, our method is post-anesthesia hookwire localization guided by preoperative CT three-dimensional reconstruction. The effectiveness and safety of this method will be studied.Methods: A total of 36 patients(36 nodules) with ground glass nodules were consecutively included in this study. Three dimensional reconstruction of chest CT was performed to simulate the puncture path. The puncture point, the depth and angle of needle insertion were recorded. After anesthesia, the puncture point was marked on the patient's body surface. Hookwire was placed according to the previous planned puncture direction and depth. The effectiveness and complications of the localization were evaluated during the operation.Results: Hookwire dislocation was found in 1 patient in operation. The other 35 nodules were successfully positioned. The median distance between hookwire and lesion was 14mm(3-25mm). The effective rate was 97.2%(35/36). Only one patient found a small amount of blood in the chest. There was no pulmonary hematoma, blood pressure or oxygen decreasing in all patients. The complication rate was 2.8% (1/36) and the severe complication was 0. The median time for localization was 3 minutes. Conclusion: Post-anesthesia hookwire localization guided by preoperative three-dimensional reconstruction is a simple, safe and effective localization method, which is suitable for appropriate nodules, and is an important supplement to CT guided localization.Trial registration: ChiCTR1900023853. Registered in Chinese Clinical Trail Registry on 14 June 2019, http://www.chictr.org.cn/showprojen.aspx?proj=40060
Intratumoral Gene Expression of Dihydrofolate Reductase and Folylpoly-C-Glutamate Synthetase Affects the Sensitivity to 5-Fluorouracil in Non-Small Cell Lung Cancer
Authors: Sakon Kayo , Sasaki Masato , Tanaka Kaede , Mizunaga Tae , Yano Keita , Kawamura Yuiko , Okada Akitoshi , Ikeda Takeshi , Tanabe Sawaka , Takamori Atsushi , Yamada Narihisa , Morioka Kouichi , Koshiji Takaaki 
Published: March 2021

Abstract
Background: Various factors related to the sensitivity of non-small cell lung carcinoma (NSCLC) to 5-fluorouracil (5-FU) have been reported, and some of them have been clinically applied. In this single-institutional prospective analysis, the mRNA expression level of five folic acid-associated enzymes was evaluated in surgical specimens of NSCLC. We investigated the correlation between the antitumor effect of 5-FU in NSCLC using an anticancer drug sensitivity test and the gene expression levels of five enzymes.Materials and Methods: Forty patients who underwent surgery for NSCLC were enrolled, and the antitumor effect was measured using an in vitro anticancer drug sensitivity test (histoculture drug response assay) using freshly resected specimens. In the same sample, the mRNA expression levels of five enzymes involved in the sensitivity to 5-FU were measured in the tumor using real-time PCR. The expression levels and the result of the sensitivity test were compared.Results: No correlation was found between dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyltransferase (OPRT), or DPD/OPRT expression and the antitumor effects of 5-FU. On the other hand, a correlation was found between thymidylate synthase (TS), folylpoly-c-glutamate synthetase (FPGS), and dihydrofolate reductase (DHFR) expression and 5-FU sensitivity.Conclusion: Expression of FPGS and DHFR may be useful for predicting the efficacy of 5-FU-based chemotherapy for NSCLC.