bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severe hypocalcemia and seizures after normalization of pCO2 in a patient with severe bronchopulmonary dysplasia and permissive hypercapnia
Authors: Bordón Sardiña Erick J. , Romero Álvarez Cristina , Díaz de Bethencourt Pardo Rocío , Urquía Martí Lourdes , García-Muñoz Rodrigo Fermín 
Published: November 2021

Abstract

Objectives
To describe the association between the rapid normalization of pCO2 after intubation in a patient with severe bronchopulmonary dysplasia managed with permissive hypercapnia, with the risk of developing hypocalcemia and seizures, and to make health care providers aware of this risk in similar cases.

Case presentation
An extreme premature infant, born at 25 weeks of gestational age (GA), developed a severe bronchopulmonary dysplasia (BPD) and, after several extubation failures could be managed with non-invasive ventilation and permissive hypercapnia, with capillary pCO2 of up to 80 mmHg and pH >7.20. At 46 postmenstrual age (PMA) he was intubated because of severe hypercapnia and compensating metabolic alkalosis. About 20 h after intubation, after normalization of pH and pCO2, he developed hypocalcemia and seizures, that remitted after iCa normalization. A comparison between arterial and capillary blood gases showed a significantly greater correlation between pH and iCa in arterial than in capillary samples.

Conclusions
Our findings emphasize the importance of avoiding the abrupt reduction of pCO2 and the close monitoring of acute metabolic changes after its correction in chronic patients with permissive hypercapnia, as well as the potential superiority of arterial samples over capillaries to improve the precision of this control.
Habitual khat chewing alters urinary inorganic profile in adult healthy males
Authors: Attafi Ibraheem M. , Albeishy Mohammed Y , Hakami Ahmed M. , Attafi Mohammad A. , Khardali Ibrahim A. 
Published: November 2021

Abstract

Objectives
Khat (Catha edulis) is a stimulant plant, and it is abusive to induce euphoria, alertness and activity. Concomitant use of medications and khat chewing predisposes to the appearance of drug interactions result in treatment failure or toxicity. This study determined the changes in the urinary inorganic profile in adult healthy males who are chewing khat compared with non-khat chewer males.

Methods
A total of 40 adult non-smoker healthy males (20 khat chewer and 20 non-khat chewer) aged 24–30 years were selected. Khat chewer samples were positive for cathinone and cathine and negative for other drug of abuse, while non-khat chewer samples were negative for drug of abuse include cathinone and cathine. Samples were selected according to their results in immunoassay and gas chromatography mass spectrometry (GCMS) analysis. Cathine and cathinone were confirmed using liquid chromatography mass spectrometry (LC-MSMS) analysis. Inorganic profile includes titanium (Ti), cobalt (Co), copper (Cu), zinc (Zn), cadmium (Cd), and lead (Pb) were determined by using inductively coupled plasma-mass spectrometry (ICP-MS).

Results
The levels of Ti, Co, Zn, Cd, and Pb in urine were significantly higher among the khat chewer group compared with non-khat chewer. Ti, Cd, Co, Pb and Zn urine levels were 0.5-, 1.5-, 1.15-, 5-, and 8.2-fold higher in the khat chewer group compared to non-khat chewer, respectively.

Conclusions
We suggested that continuous khat chewing has a long term effect on metabolic pathway of therapeutic drugs that result in toxicity or failure of therapy.
In vitro inhibitory effects of glucosamine, chondroitin and diacerein on human hepatic CYP2D6
Authors: Tan Boon Hooi , Ahemad Nafees , Pan Yan , Palanisamy Uma Devi , Othman Iekhsan , Ong Chin Eng 
Published: November 2021

Abstract

Objectives
Glucosamine, chondroitin and diacerein are natural compounds commonly used in treating osteoarthritis. Their concomitant intake may trigger drug–natural product interactions. Cytochrome P450 (CYP) has been implicated in such interactions. Cytochrome P450 2D6 (CYP2D6) is a major hepatic CYP involved in metabolism of 25% of the clinical drugs. This study aimed to investigate the inhibitory effect of these antiarthritic compounds on CYP2D6.

Methods
CYP2D6 was heterologously expressed in Escherichia coli. CYP2D6–antiarthritic compound interactions were studied using in vitro enzyme kinetics assay and molecular docking.

Results
The high-performance liquid chromatography (HPLC)-based dextromethorphan O-demethylase assay was established as CYP2D6 marker. All glucosamines and chondroitins weakly inhibited CYP2D6 (IC50 values >300 µM). Diacerein exhibited moderate inhibition with IC50 and K

i
values of 34.99 and 38.27 µM, respectively. Its major metabolite, rhein displayed stronger inhibition potencies (IC50=26.22 μM and K

i
=32.27 μM). Both compounds exhibited mixed-mode of inhibition. In silico molecular dockings further supported data from the in vitro study. From in vitro–in vivo extrapolation, rhein presented an area under the plasma concentration-time curve (AUC) ratio of 1.5, indicating low potential to cause in vivo inhibition.

Conclusions
Glucosamine, chondroitin and diacerein unlikely cause clinical interaction with the drug substrates of CYP2D6. Rhein, exhibits only low potential to cause in vivo inhibition.
Prevalence of alcohol-drug interactions in community-dwelling older patients with polypharmacy
Authors: Gorsen Santina L. , Mehuys Els , De Bolle Leen , Boussery Koen , Tommelein Eline 
Published: November 2021

Abstract

Objectives
Alcohol and medication use are increasingly prevalent in the older population. Concurrent use of alcohol and alcohol-interactive (AI) medication can lead to significant adverse consequences.

Methods
Three reference works were used to create an explicit list of drug substances for which information about the interaction with alcohol was available in at least one of them. Additional information was extracted from the Summary of Product Characteristics (SPC). The first aim was to generate a list of 256 substances with standardized advice regarding the concurrent use of each drug with alcohol. The second aim was to observe the prevalence of potential drug–alcohol-interactions. The list was applied to a database containing information about alcohol and medication use of 1,016 community-dwelling older patients (≥70 years) with polypharmacy.

Results
About half of the sample population reported to consume alcohol at least once a week. Around 22% were classified as frequent drinkers (5–7 days/week) and 11% as heavier drinkers (>7 units/week). Ninety-three percent alcohol consumers in our sample took at least one chronic drug that potentially interacts with alcohol and 42% used at least one chronic drug for which alcohol use is considered contraindicated.

Conclusions
We developed an explicit list of potentially drug–alcohol-interactions in older adults, with standardized handling advice. We observed that prevalence of potential drug–alcohol-interactions is substantial in community-dwelling older patients with polypharmacy.
A sociosemiotic exploration of medical legislation reform in China (1990–2021)
Authors: Zhao Junfeng , Wu Jingjing , Yang Yi 
Published: November 2021

AbstractThe medical service system is an important guarantee for human rights to survival, health and development of every social member, and thus it is significant to explore, interpret and explain the diachronic construction for its legislative reform. In a corpus approach, the study firstly collects the medical-related statutes from 1990 to 2021 in China to build the P.R.C. Medical Legislation Corpus (PRCMLC), and analyzes the keywords and their collocation in the exploratory, explosive and expanding phase of the medical legislative reform. Secondly, from the perspectives of sociosemiotics, the PRCMLC data is combined with the concrete medical laws and regulations for further discussion of the MSS, MIS, DSS and PHS in legislative system. Thirdly, the study explores the core legislative ideas and the relationships among the subsystems in the diachronic analysis, which provide a general overview of the legislative objects, target, participants and mechanisms in the medical reform of China.
One-dimensional optimal system and similarity transformations for the 3 + 1 Kudryashov–Sinelshchikov equation
Authors: Paliathanasis Andronikos 
Published: November 2021

Abstract
We apply the Lie theory to determine the infinitesimal generators of the one-parameter point transformations which leave invariant the 3 + 1 Kudryashov–Sinelshchikov equation. We solve the classification problem of the one-dimensional optimal system, while we derive all the possible independent Lie invariants; that is, we determine all the independent similarity transformations which lead to different reductions. For an application, the results are applied to prove the existence of travel-wave solutions. Furthermore, the method of singularity analysis is applied where we show that the 3 + 1 Kudryashov–Sinelshchikov equation possess the Painlevé property and its solution can be written by using a Laurent expansion.
Solitary waves of the RLW equation via least squares method
Authors: Hepson Ozlem Ersoy , Dag Idris , Saka Bülent , Ay Buket 
Published: November 2021

Abstract
Integration using least squares method in space and Crank–Nicolson approach in time is managed to set up an algorithm to solve the RLW equation numerically. Trial functions in the least square method consist of a combination of the quartic B-spline functions. Integration of the RLW equation gives a system of algebraic equations. The solutions consisting of a combination of the quartic B-splines are given for some initial and boundary value problems of RLW equation.
The acquisition of relative clauses by Spanish-Basque learners of L3 English: does dominance play a role?
Authors: Ramos Feijoo Jon , García Mayo María del Pilar 
Published: November 2021

AbstractSeveral studies in the area of third language acquisition (L3A) have considered various factors influencing this process, but the effect of language dominance has not been thoroughly examined. The main goal of this study is to investigate whether the acquisition of relative clauses (RCs) in L3 English is influenced by language internal factors, such as the syntactic features of the target language, or by external factors in the form of cross-linguistic influence (CLI). A total of 90 participants (40 Spanish-dominant, 40 Basque-dominant, 10 L1 Spanish-L2 English) and 10 native speakers of English completed a production and a comprehension task. Findings show that the L3 learners’ production of RCs seems to be driven by language internal factors, whereas their comprehension appears to be influenced by their previously acquired languages, mainly by Spanish. It is concluded that neither language dominance nor other traditionally considered factors play a determinant role in the acquisition of RCs in L3 English by these participants.
Automated near-field deformation detection from mobile laser scanning for the 2014 Mw 6.0 South Napa earthquake
Authors: Zhu Xinxiang , Glennie Craig L. , Brooks Benjamin A. 
Published: November 2021

Abstract
Quantifying off-fault deformation in the near field remains a challenge for earthquake monitoring using geodetic observations. We propose an automated change detection strategy using geometric primitives generated using a deep neural network, random sample consensus and least squares adjustment. Using mobile laser scanning point clouds of vineyards acquired after the magnitude 6.0 2014 South Napa earthquake, our results reveal centimeter-level horizontal ground deformation over three kilometers along a segment of the West Napa Fault. A fault trace is detected from rows of vineyards modeled as planar primitives from the accumulated coseismic response, and the postseismic surface displacement field is revealed by tracking displacements of vineyard posts modeled as cylindrical primitives. Interpreted from the detected changes, we summarized distributions of deformation versus off-fault distances and found evidence of off-fault deformation. The proposed framework using geometric primitives is shown to be accurate and practical for detection of near-field off-fault deformation.
Effect of cell phone use on salivary components; a review of literature
Authors: Arbabi Kalati Fateme , Nosratzehi Tahereh 
Published: November 2021

Abstract
Mobile phones have been increasingly used in the past decade and have become a cultural instrument. There is a great concern over the harmful effects of electromagnetic and radiofrequency waves as well as microwaves generated by mobile phones and their telecommunication stations on health. The saliva plays an important role in preserving oral homeostasis as the first defensive line against the microbial invasion which protects oral mucosa mechanically and immunologically. A search was run in PubMed, Goggle Scholar, Medline, and Web of Science databases using the following keywords: cell phone, mobile phone, antioxidant profile, saliva, oxidative stress, interleukin, and inflammation. Sixty-five published articles were identified. Studies on the use of cell phones as educational aids, the use of immune histochemistry on salivary glands, or the evaluation of saliva in individuals with specific conditions, such as the use of orthodontic brackets, were excluded. In addition, duplicate articles are eliminated, and finally, 14 articles were included in the present study. Nowadays mobile phone is very popular, causing concern about the effect it has on people’s health. Parotid salivary glands are in close contact with a cell phone while talking with the phone and the possibility of being affected by them; so this study was designed to investigate the effect of cell phone use on salivary components.
Tree-based machine learning algorithms in the Internet of Things environment for multivariate flood status prediction
Authors: Aswad Firas Mohammed , Kareem Ali Noori , Khudhur Ahmed Mahmood , Khalaf Bashar Ahmed , Mostafa Salama A. 
Published: November 2021

Abstract
Floods are one of the most common natural disasters in the world that affect all aspects of life, including human beings, agriculture, industry, and education. Research for developing models of flood predictions has been ongoing for the past few years. These models are proposed and built-in proportion for risk reduction, policy proposition, loss of human lives, and property damages associated with floods. However, flood status prediction is a complex process and demands extensive analyses on the factors leading to the occurrence of flooding. Consequently, this research proposes an Internet of Things-based flood status prediction (IoT-FSP) model that is used to facilitate the prediction of the rivers flood situation. The IoT-FSP model applies the Internet of Things architecture to facilitate the flood data acquisition process and three machine learning (ML) algorithms, which are Decision Tree (DT), Decision Jungle, and Random Forest, for the flood prediction process. The IoT-FSP model is implemented in MATLAB and Simulink as development platforms. The results show that the IoT-FSP model successfully performs the data acquisition and prediction tasks and achieves an average accuracy of 85.72% for the three-fold cross-validation results. The research finding shows that the DT scores the highest accuracy of 93.22%, precision of 92.85, and recall of 92.81 among the three ML algorithms. The ability of the ML algorithm to handle multivariate outputs of 13 different flood textual statuses provides the means of manifesting explainable artificial intelligence and enables the IoT-FSP model to act as an early warning and flood monitoring system.
Electronic tools in clinical laboratory diagnostics: key examples, limitations, and value in laboratory medicine
Authors: Bohn Mary Kathryn , Fabiano Giulia F. , Adeli Khosrow 
Published: November 2021

Abstract
Electronic tools in clinical laboratory diagnostics can assist laboratory professionals, clinicians, and patients in medical diagnostic management and laboratory test interpretation. With increasing implementation of electronic health records (EHRs) and laboratory information systems worldwide, there is increasing demand for well-designed and evidence-based electronic resources. Both complex data-driven and simple interpretative electronic healthcare tools are currently available to improve the integration of clinical and laboratory information towards a more patient-centered approach to medicine. Several studies have reported positive clinical impact of electronic healthcare tool implementation in clinical laboratory diagnostics, including in the management of neonatal bilirubinemia, cardiac disease, and nutritional status. As patients have increasing access to their medical laboratory data, it is essential that accessible electronic healthcare tools are evidence-based and user-friendly for individuals of varying digital and medical literacy. Indeed, studies suggest electronic healthcare tool development processes significantly lack the involvement of relevant healthcare professionals and often present misinformation, including erroneous calculation algorithms or inappropriate interpretative recommendations. The current review provides an overview of the utility of available electronic healthcare tools in clinical laboratory diagnostics and critically reviews potential limitations and benefits of their clinical implementation. The Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) online database is also detailed as an example of a pediatric diagnostic tool with widespread global impact.
The impact of the COVID-19 pandemic on child health
Authors: Nijman Ruud G. 
Published: November 2021

Abstract
Most Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections in children are mild or asymptomatic. Severe Coronavirus Disease 2019 (COVID-19) in children is infrequent. An estimated 0.3–1.3% of children with SARS-CoV-2 infection were admitted to hospital, and of these 13–23% needed critical care. SARS-CoV-2 related deaths were very rare in children, estimated at 2 per million. The vast majority of admitted children had one of shortness of breath, fever, and cough, but atypical symptoms are more common in children. Cases of Multisystem Inflammatory Syndrome in Children (MIS-C) have been linked to SARS-CoV-2 infection. Cardinal symptoms include prolonged fever, clinical signs of inflammation, gastro-intestinal symptoms, and cardiac dysfunction. Twenty two to 80% of patients with MIS-C needed critical care; mortality of MIS-C is around 2%. Six to 24% of children with MIS-C had coronary artery dilatation or cardiac aneurysms. Equipoise still exists between first-line treatment with immunoglobulins and steroids. Outcomes for children with MIS-C are generally very good in those recognised early and started on appropriate treatment. Vaccination schemes for children are rapidly expanding, with the benefits of preventing severe COVID-19 disease and MIS-C and reducing community transmission outweighing the risks of adverse events of, amongst others, myocarditis temporally related to COVID-19 vaccination in children and young adults. The imposed social distancing measures reduced the overall number of children with acute illness or injury presenting to urgent and emergency care facilities worldwide. No clear signal was seen that large numbers of children had a delayed presentation to emergency care departments with a serious illness. The social distancing measures negatively impacted the mental health of children.
Towards developing multimodal literacies in the ESP classroom: methodological insights and practical applications
Authors: Crawford Camiciottoli Belinda , Fortanet-Gómez Inmaculada 
Published: November 2021

Abstract
In this article, we provide an introduction to this special issue of Multimodal Communication entitled “Multimodal approaches in ESP: Innovative research and practice”. The Special Issue showcases innovative research presented at the 2019 International Conference on Knowledge Dissemination and Multimodal Literacy: Research Perspectives on ESP in a Digital Age. After briefly discussing the multimodal approach in language teaching and specifically in English for Specific Purposes (ESP) and its key role in developing multimodal competence, each of the five featured contributions is previewed. The contributions offer theoretically grounded and research-informed applications of the multimodal approach in the ESP classroom.
Selbst-Bildungen. The Tradition of Comedy and the Emancipation of German Jews in Carl Sternheim’s The Snob
Authors: Habel Sabrina 
Published: November 2021

Abstract
The article explores the connection between enlightenment and comedy, as well as its importance for German Jewry. Following Hegel, whose thoughts on ancient drama as well as modern society have shaped the German discourse on comedy until today, this article demonstrates that questions of self-formation, emancipation, and historical self-location are central to comedy. In Carl Sternheim’s comedy The Snob, the idea of self-formation resonates with the historic concept of “civic improvement” through “Bildung”: Jewish emancipation in Germany stood at the end of an educational project that outlasted Jews’ achieving legal equality. The Snob is a comedy about Jewish acculturation and bourgeoisification and embodies Marx’s understanding of comedy as ambivalent: on the one hand, comedy helps people to part cheerfully from their past that was characterized by inequality, but, on the other, it indicates that a world-historic fact like Jewish emancipation may be prone to repeat itself as a farce. Sternheim’s comedy develops a poetic that embraces ambivalence, but also opens the genre of comedy to the question of therapy and healing. It depicts the struggle between autonomy and social formation – the dialectics of German “Bildung.”
Pressure assisted sintering of Al2O3–Y2O3 glass microspheres: sintering conditions, grain size, and mechanical properties of sintered ceramics
Authors: Prnová Anna , Valúchová Jana , Michálková Monika , Pecušová Beáta , Parchovianský Milan , Švančárek Peter , Hanzel Ondrej , Pouchlý Václav , Galusek Dušan 
Published: November 2021

Abstract
Glass microspheres with yttria-alumina eutectic composition (76.8 mol% Al2O3 and 23.2 mol% Y2O3) were prepared by sol-gel Pechini method and flame synthesis with or without subsequent milling. Prepared amorphous powders were studied by X-ray powder diffraction (XRD), particle size analysis (PSA), scanning electron microscopy (SEM) and differential thermal analysis (DTA). Hot pressing (HP), rapid hot pressing (RHP) and spark plasma sintering (SPS) were used to sinter amorphous precursor powders at 1600 °C without holding time (0 min). The preparation process including milling step resulted in amorphous powders with narrower particle size distribution and smaller particle size. All applied pressure assisted sintering techniques resulted in dense bulk samples with fine grained microstructure consisting of irregular α-Al2O3 and Y3Al5O12 (YAG) grains. Milling was beneficial in terms of final microstructure refinement and mechanical properties of sintered materials. A material with the Vickers hardness of HV = (17.1 ± 0.3) GPa and indentation fracture resistance of (4.2 ± 0.2) MPa.m1/2 was prepared from the powder milled for 12 h.