Comparison of the prognostic significance of 5 comorbidity scores and 12 functional tests in a prospective multiple myeloma patient cohort
Authors: Scheubeck Sophia , Ihorst Gabriele , Schoeller Katja , Holler Maximilian , Möller Mandy‐Deborah , Reinhardt Heike , Wäsch Ralph , Engelhardt Monika 
Published: June 2021

BackgroundBecause of the various therapeutic options available for multiple myeloma (MM), remarkable interest exists today in individualized therapeutic concepts based on patients' fitness. The main objectives of this study were to compare different comorbidity scores and functional tests with respect to their impact on survival (overall survival [OS] and progression‐free survival [PFS]); develop a time‐efficient, MM‐specific functional assessment (FA); and evaluate changes in patients' FA during treatment.MethodsThe authors performed a prospective FA in 266 consecutive patients with MM at their initial diagnosis. This included 5 comorbidity scores and 12 commonly used geriatric functional tests. To evaluate changes in the course of treatment, the authors reassessed these 17 tests after ≥6 months. The entire analysis included 7327 FA tests.ResultsOn the basis of univariate and multivariate Cox regression analyses, the authors identified 4 of the 17 evaluated scores and functional tests as most relevant: the Revised Myeloma Comorbidity Index (R‐MCI), Activity of Daily Living (ADL), the Mini‐Mental State Examination (MMSE), and the quality‐of‐life 12‐Item Short Form Health Survey Physical Composite Scale (SF‐12 PCS). These showed precise group differences for fit, (intermediate‐fit), and frail patients in OS and PFS: the 3‐year OS rates were 90%, 74%, and 43% via the R‐MCI for fit, intermediate‐fit, and frail patients, respectively (P = .0006); 80% and 66% via the ADL for fit and frail patients, respectively (P = .0159); 78% and 48% via the MMSE for fit and frail patients, respectively (P = .0001); and 86% and 66% via the SF‐12 PCS for fit and frail patients, respectively (P = .0091). In follow‐up analyses, 16 of 17 FA tests improved, mostly in younger patients (<70 years old) and responding patients (partial remission or better).ConclusionsPatients may recover from functional and physical limitations under applied MM therapy. The newly established MM‐specific FA (via the R‐MCI, ADL, MMSE, and SF‐12 PCS) allows a precise evaluation of the prognosis and risk status in MM. Its use may improve treatment tolerability and should be validated to individualize MM treatment decisions in the future.Lay Summary

The authors performed a prospective functional assessment (FA) in 266 consecutive patients with multiple myeloma at their initial diagnosis.

On the basis of univariate and multivariate Cox regression analyses, the authors identified 4 of 17 initially evaluated scores and functional tests as most relevant: the Revised Myeloma Comorbidity Index, Activity of Daily Living, the Mini‐Mental State Examination, and the quality‐of‐life 12‐Item Short Form Health Survey Physical Composite Scale.

The authors checked the stability of the final model by applying forward and stepwise selection. To evaluate changes in the course of treatment, they reassessed these 17 tests in 165 patients after ≥6 months: 16 of the 17 FA tests improved, mostly in younger patients (<70 years old) and responding patients (partial remission or better).