bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prophylaxis for patients at Risk to Eliminate Post-operative Atrial Fibrillation (PREP-AF trial): a protocol for a feasibility randomized controlled study
Authors: Smith Heather A. , Kanji Salmaan , Tran Diem T. T. , Redpath Calum , Ferguson Dean , Lenet Tori , Sigler Greg , Gilbert Sebastien , Maziak Donna , Villeneuve Patrick , Sundaresan Sudhir , Seely Andrew J. E. 
Published: June 2021

Abstract
Background
Postoperative atrial fibrillation (POAF) is a frequent adverse event after thoracic surgery with associated morbidity, mortality, and healthcare costs. It has been shown to be preventable with prophylactic amiodarone, which is only recommended in high-risk individuals due to the potential associated side effects. Risk factors for POAF have been identified and incorporated into a prediction model to identify high-risk patients. Further evaluation in the form of a multicenter clinical trial is required to assess the effectiveness of prophylaxis specifically in this high-risk population. The feasibility of such a trial first needs to be assessed.

Methods
The PREP-AF trial is a double-blind randomized controlled feasibility trial. Individuals undergoing major thoracic surgery who are identified to be high-risk by the POAF prediction model will be randomized 1:1 to receive a short course of amiodarone vs. placebo in the immediate postoperative period. The primary outcome is feasibility, which will be measured by the number of eligible patients identified, consented, and randomized; intervention adherence; and measurement of future outcomes of a full trial.

Discussion
This study will determine the feasibility of a randomized controlled trial to assess the effectiveness of prophylactic amiodarone, in high-risk patients undergoing major thoracic surgery. This will inform the development of a multi-center trial to establish if prophylactic amiodarone is safe and effective at reducing the incidence of POAF. Preventing this adverse event will not only improve outcomes for patients but also reduce the associated health resource utilization and costs.

Trial registration
ClinicalTrials.gov NCT04392921. Registered on 19 May 2020.
Auricular acupressure for myopia prevention and control in children and its effect on choroid and retina: a randomized controlled trial protocol
Authors: Han Rong , Kong Xie-he , Zhao Feng , Yang Yan-ting , Dong Xiao-qing , Zeng Li , Chen Zhi , Zhao Yue , Yang Guang , Hong Jue , Zhou Xing-tao , Ma Xiao-peng 
Published: June 2021

Abstract
Background
Nowadays, because of the increasing incidence, the prevention and control of myopia has become an urgent issue. In China, auricular acupressure has been commonly used in the clinical treatment of myopia in children, but the exact effectiveness remains unproven. The purpose of this trial is to observe the efficacy of auricular acupressure in myopia prevention and control, as well as its effect on the choroidal and retinal thickness.

Method/design
A total of 480 subjects at 8–9 years old will be randomized in a 1:1 ratio to an intervention group versus a control group. The intervention group will receive auricular acupressure for 12 months, while the control group will be taken as a blank control. The primary and secondary outcomes will be measured at baseline, and again at 3, 6, 9, and 12 months after recruitment. The myopia incidence (spherical equivalent ≤ − 0.50 D) and the mean change of spherical equivalent will be taken as the primary variables; the secondary outcome measures include axial length, uncorrected visual acuity, and choroidal and retinal thickness.

Discussion
This trial aims to evaluate the effectiveness of auricular acupressure for myopia prevention and control with objective evidence and to preliminarily explore the plausible mechanism and provide reference for adopting this approach to retard the onset and control the progression of myopia.

Trial registration
Chinese Clinical Trial Registry ChiCTR2000038456. Registered on September 23, 2020.
Maternal low-intensity psychosocial telemental interventions in response to COVID-19 in Qatar: study protocol for a randomized controlled trial
Authors: Naja Sarah , Elyamani Rowaida , Chehab Mohamad , Siddig Mohamed , Al Ibrahim Abdullah , Mohamad Tagreed , Singh Rajvir , Bougmiza Iheb 
Published: June 2021

Abstract
Introduction
As COVID-19 is spreading, new psychological health problems are suspected to be emerging among pregnant women. Higher maternal mental health distress, including perinatal anxiety, depression, and COVID-19-specific phobia, is supposed to be increasing during the pandemic, which impacts pregnant women’s health and their infants and calls for intervention. Due to the social distancing protocols posed by the pandemic, telemental health interventions have fast become the most common form of psychosocial support for maternal mental health. However, there is no evidence of the effectiveness of maternal low-intensity psychosocial telemental interventions in improving mental health outcomes. The trial’s objective is to evaluate the clinical efficacy of telemental low-intensity psychosocial interventions in pregnant and postpartum women attending the Women Wellness and Research Centre in Qatar in the era of the COVID-19 pandemic.

Methods and analysis
The clinical trial is randomized in which pregnant women will be assigned equally through block randomization between two arms: (1) a control group and (2) an intervention group. The primary endpoint is the perinatal psychological distress, including perinatal depression, anxiety, and COVID-19 phobia in their third trimester; the secondary, tertiary, fourth, and fifth endpoints will be in the postnatal period (3–5 weeks, 2–4 months, 5–7 months, and 8–10 months). This trial involves pregnant women in their second trimester with no mental health illness history who communicate in English and Arabic and consent to participate. A sample size of 58 (29 participants per arm) is targeted.

Discussion
This study will provide recommendations about the efficacy of low-intensity psychosocial maternal telemental interventions to be implemented as a preventive service.

Trial registration
2a-ClinicalTrials.gov NCT04594525. Registered on October 20, 2020.
The quality of intervention reporting in trials of therapeutic exercise for hip osteoarthritis: a secondary analysis of a systematic review
Authors: Burgess Louise C. , Wainwright Thomas W. , James Khara A. , von Heideken Johan , Iversen Maura D. 
Published: June 2021

AbstractBackgroundTherapeutic exercise is recommended as a core treatment for hip osteoarthritis (HOA). Whilst it is widely accepted that exercise can improve pain and disability, optimal type and dose of exercise are yet to be agreed upon. This may, in part, be attributed to the wide variation and inadequate reporting of interventions within the literature. This study evaluates the quality of intervention reporting among trials of therapeutic exercise in HOA.MethodsRandomised controlled trials (RCTs) were sourced in a systematic review, completed in August 2020. Two raters independently used the Template for Intervention Description and Replication (TIDieR) and Consensus on Exercise Reporting Template (CERT) to evaluate intervention reporting. Correlations between quality assessment scores and CERT and TIDieR scores evaluated the relationship between internal validity and external applicability. The year of publication was compared to the quality of reporting scores.ResultsFourteen RCTs were included in the analysis. On average, studies were awarded 9.43 ± 1.95 out of 12 points for the TIDieR checklist (range 4–12) and 13.57 ± 4.01 out of 19 points for the CERT (range 5–19). Pearson’s correlation coefficient suggested that the quality of reporting had improved over time and that there was a fair, positive relationship between internal validity and external applicability.DiscussionWhilst the quality of intervention reporting is improving, many RCTs of therapeutic exercise in HOA lack the detail necessary to allow accurate evaluation and replication. Researchers are encouraged to utilise the standardised reporting guidelines to increase the translation of effective interventions into clinical practice.
Extensions of Hermite–Hadamard inequalities for harmonically convex functions via generalized fractional integrals
Authors: You Xue-Xiao , Ali Muhammad Aamir , Budak Hüseyin , Agarwal Praveen , Chu Yu-Ming 
Published: June 2021

AbstractIn the paper, the authors establish some new Hermite–Hadamard type inequalities for harmonically convex functions via generalized fractional integrals. Moreover, the authors prove extensions of the Hermite–Hadamard inequality for harmonically convex functions via generalized fractional integrals without using the harmonic convexity property for the functions. The results offered here are the refinements of the existing results for harmonically convex functions.
Dynamics of a lake-eutrophication model with nontransient/transient impulsive dredging and pulse inputting
Authors: Jiao Jianjun , Tang Wenyan 
Published: June 2021

AbstractIn this work, we present a lake-eutrophication model with nontransient/transient impulsive dredging and pulse inputting. We obtain globally asymptotically stable conditions for the phytoplankton-extinction periodic solution of system (2.1). Furthermore, we gain the permanent conditions for system (2.1). Finally, we employ computer simulations to illustrate the results. Our results indicate the effective controlling strategy for water resource management.
Introducing 3D printed models of the upper urinary tract for high-fidelity simulation of retrograde intrarenal surgery
Authors: Orecchia Luca , Manfrin Diego , Germani Stefano , Del Fabbro Dario , Asimakopoulos Anastasios D. , Finazzi Agrò Enrico , Miano Roberto 
Published: June 2021

Abstract
Purpose
Training in retrograde intrarenal surgery for the treatment of renal stone disease is a challenging task due to the unique complexity of the procedure. This study introduces a series of 3D printed models of upper urinary tract and stones designed to improve the training process.

Methods
Six different models of upper urinary tract were algorithmically isolated, digitally optimized and 3D printed from real-life cases. Soft and hard stones in different sizes were produced from 3D printed moulds. The models were fitted onto a commercially available part-task trainer and tested for retrograde intrarenal surgery.

Results
Each step of the procedure was simulated with extraordinary resemblance to real-life cases. The unique anatomical intricacy of each model and type of stones allowed us to reproduce surgeries of increasing difficulty. As the case-load required to achieve proficiency in retrograde intrarenal surgery is high, benchtop simulation could be integrated in training programs to reach good outcomes and low complication rates faster. Our models match incredible anatomical resemblance with low production cost and high reusability. Validation studies and objective skills assessment during simulations would allow comparison with other available benchtop trainers and the design of stepwise training programs.

Conclusions
3D printing is gaining a significant importance in surgical training. Our 3D printed models of the upper urinary tract might represent a risk-free training option to hasten the achievement of proficiency in endourology.
Depression and anxiety among hyperthyroid female patients and impact of treatment
Authors: Shoib Sheikh , Ahmad Javid , Wani Manzoor Ahmed , Ullah Irfan , Tarfarosh Shah Faisal Ahmad , Masoodi Shariq Rashid , Ramalho Rodrigo 
Published: June 2021

Abstract
Background
The aim of the present study was to compare the presence of psychiatric disorders in people with hyperthyroidism and euthyroid patients attending the Endocrinology Outpatient Department at the Shri Maharaja Hari Singh Hospital in Kashmir, India. Seventy-five patients with hyperthyroidism and an equal number of euthyroid patients participated in the study. Participants were selected using stratified random sampling. All patients were female. There was no significant difference between the two groups in terms of demographic features. Hormonal screening was performed by immunoassay and haemagglutination method. For the mental health assessment, the Mini-International Neuropsychiatric Interview (MINI), Hamilton Depression Rating Scale [HAM-D], and Hamilton Anxiety Rating Scale [HAM-A] were used.

Results
There was a higher prevalence of psychiatric disorders among the hyperthyroidism group (60% versus 34.7%). In particular, there was a higher prevalence of major depressive disorder, suicidality, generalised anxiety disorder, panic attacks, and agoraphobia. In some cases, the prevalence of a psychiatric disorder diminished after endocrinological treatment.

Conclusions
Screening patients with hyperthyroid disorders for psychiatric symptoms and disorders, and providing timely care when necessary, can go a long way in improving the quality of life of this population. It is imperative to establish routine screening and timely care of mental health symptoms and disorders in patients with hyperthyroidism.
Application of RP-HPLC method for the simultaneous determination of cetirizine in the presence of quinolones
Authors: Shamshad Hina , Mirza Agha Zeeshan 
Published: June 2021

Abstract
Background
Present work describes a fast, simple, and sensitive procedure for the simultaneous determination of cetirizine in the presence of quinolones using diclofenac sodium as an internal standard. The present work was designed to analyze these compounds in pharmaceutical and clinical labs being economical for use.

Results
The mobile phase consisted of the simple composition of methanol, acetonitrile, and water in a ratio of 50:20:30 with a pH adjusted to 3.1 at a flow rate of 1 mL min−1. The UV detection was performed at 225 nm. The linearity was assessed over the range of 2.5–50 μg mL−1 for all drugs. The parameters such as accuracy, precision, linearity (>0.999), and sensitivity were satisfactory.

Conclusion
The method was equally applicable for formulation and human serum with recovery values between 95 and 105%. The results of the method were validated statistically according to ICH guidelines.
Endocrine Nurses Society Position Statement on Transgender and Gender Diverse Care
Authors: Dwyer Andrew A , Greenspan Debra L 
Published: June 2021

Abstract
The Endocrine Nurses Society (ENS) is committed to clinical excellence in the art and science of endocrine nursing throughout the world. ENS recognizes that transgender and gender diverse (TGD) individuals face challenges and inequities that place them in the realm of health disparities. Further, TGD individuals often face substantial barriers to care and have difficulty finding healthcare providers who are knowledgeable about the unique health needs of this patient population. ENS recognizes that endocrine nurses care for young adult and adult TGD individuals. This position statement outlines recommendations for healthcare providers and organizations seeking to embrace a gender-affirming approach to care and increase access to high-quality, comprehensive care for TGD individuals. This Position Statement was accepted by ENS on September 8, 2020 and has been endorsed by the European Society of Endocrinology Nurse Committee, European Society of Paediatric Endocrinology Nurses, Pediatric Endocrine Nursing Society, Endocrine Nurses’ Society of Australasia, and the Federation of International Nurses in Endocrinology.
The impact of long-term exposure to anticholinergics among people with intellectual disabilities: a scoping review protocol
Authors: Al Shuhaimi Lamya , Henman Martin , McCallion Philip , McCarron Mary , O'Dwyer Maire 
Published: June 2021

Background: Older adults with intellectual disability often take multiple medicines with anticholinergic activity and sedative properties to manage multi-morbidity; the use of medication with anticholinergic activity has been found to be associated with various cognitive and physical impairments. However, there are limited studies that have examined the long-term impact of anticholinergic use among older adults. Therefore, this protocol is designed to conduct a scoping review to examine the available data on the long-term impact of anticholinergic use in older adults with intellectual disability. Aim and objectives: The aim of this scoping review is to a) map and b) examine the existing research literature to answer the research question: What is the impact on cognitive and physical outcomes of long-term exposure to medications with anticholinergic activity among older adults with intellectual disabilities? Methods and analysis: This scoping review will follow the methodology framework of Arksey and O’Malley and its developed version by Levac. The framework consists of a six-stage process to be conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis extension for Scoping Reviews (PRISMA-ScR) reporting guidelines. The search strategy will include the following electronic data bases: Pubmed, Cochrane library, EMBASE, Medline, Science Direct, CINAHL Complete and PsycINFO. The search will include terms related to ‘Anticholinergic burden’, ‘Intellectual disability’, ‘Adverse drug reaction’ and ‘long-term impact’ with Boolean operator ‘and’. The scoping review will include studies with at least 3 months exposure to anticholinergics. The collected data will be mapped as a tabular presentation of the various physical and cognitive adverse effects associated with long-term use of anticholinergics in this group of population.
Demographic and health characteristics of 3,4-methylenedioxymethamphetamine users (MDMA, ecstasy)
Authors: Więckiewicz Gniewko , Danel Dariusz , Piegza Magdalena , Gorczyca Piotr , Pudlo Robert 
Published: June 2021

Cel pracyMDMA to jedna z najczęściej stosowanych substancji psychoaktywnych na świecie. Obecnie w wielu krajach prowadzone są badania kliniczne nad zastosowaniem tej substancji w leczeniu PTSD i alkoholizmu. Dostępnych jest jednak niewiele informacji demograficznych na temat użytkowników, którzy używają substancji w celach pozamedycznych. Celem było określenie podstawowych cech demograficznych i zdrowotnych za pomocą zwalidowanych narzędzi.MetodaAutorzy przygotowali oryginalny kwestionariusz dotyczący demografii osób używających MDMA i połączyli go z Kwestionariusze Ogólnego Stanu Zdrowia (GHQ-28) oraz Szpitalną Skalą Lęku i Depresji (HADS). Ankieta została rozesłana do polskich użytkowników MDMA za pośrednictwem internetu.WynikiOtrzymano 304 odpowiedzi od osób powyżej 18 roku życia. MDMA jest szeroko rozpowszechnione wśród młodych dorosłych, w wielu różnych miejscach zamieszkania i niezależnie od płci. Użytkownicy zażywają MDMA zarówno w formie pigułki, jak i kryształu, i bardzo rzadko testują substancje psychoaktywne zakupione od sprzedawcy. Większość użytkowników uważa, że ​​MDMA dobrze wpłynęło na ich życie.WnioskiMDMA jest rzadko używane jako jedyna substancja psychoaktywna. Użytkownicy MDMA oceniają stan swojego zdrowia wyżej niż osoby używające innych substancji psychoaktywnych.
The incidence of significant correlations between body height and weight and foot parameters among 7-13-year-old children of both sexes and environments
Authors: Mrozkowiak Mirosław 
Published: June 2021

The purpose of this study was to present the incidence of significant correlations between body weight and height and the selected parameters of feet among 7-13-year-old children.
Material and methods. The study which was conducted among children aged 7-13 years during the period of 3 years, in 6 half-year editions, allowed the author to record 16462 observations with regard to the measurement of 48 parameters describing feet, body weight and height. The photogrammetric method was used to measure the selected parameters.
Conclusions
1.Among children aged 7-13 years, body height revealed significantly more frequent correlations with the parameters of feet than body weight.
Body height was reported to reveal more frequent significant correlations with the parameters of feet than body weight among boys and girls. As regards girls involved in the study, the proportions concerning the frequency of relationships concerning body height were similar to the percentage represented by boys whereas body-weight-related correlations were more frequent. Body weight and height were reported to correlate more often with the parameters of feet in the case of children living in the urban areas than those from the rural regions.
2.Among boys, the most frequent significant correlations between body weight and height and the parameters of feet were observed in subjects living in the urban environment. The percentage of relationships between body weight parameters observed in the rural environment was very low. Among girls from towns and cities, the prevalence of correlations between body weight and height outnumbered the rate of relationships in the rural environment.
Effect Of Peer Tutoring On Students’ Academic Achievement In Office Technology And Mangement In Nigerian Polytechnics
Authors: Ehirheme Pauline Egberanmwen , Eze Titus Iloduba 
Published: June 2021

Students of Office Technology and Management (OTM) in Nigerian polytechnics have consistently performed below expectations both academically and at work. This may be attributed to use of inappropriate instructional method. The need to improve this situation necessitated the research on effects of peer tutoring on students’ academic achievement in OTM in Nigerian polytechnics. Using a research question to guide the study, and a null hypothesis was tested at 0.05 level of significance. A non-randomized quasi experimental research design, adopting pre-test; post-test non-equivalent control group design was used. South West Nigeria was the region of the research work with a populace of 503 National Diploma Year II (ND II) OTM students in four federal polytechnics. Using cluster random sampling, a sample of the intact classes of 227 students from two states in the area of the study was drawn. Three OTM experts validated the “Office Technology and Management Achievement Test (OTMAT)” 100 items instrument for face and content validity. The Experts input modified some items and cancelled some which reduced 140 test items to 100 used for collecting data. Descriptive statistics of mean was used to analyze data and to respond to the research question while t-test and Analysis of Covariance were used to test the null hypothesis. Kuder-Richardson Formula 21 was adopted to establish internal consistency and reliability of the instrument which yielded a coefficient of 0.86. The research showed that Peer Tutoring Instructional Technique (PTIT) has higher positive effects on students’ academic achievement in OTM than Teacher-dominated Instructional Approach (TDIA), thus it can enhance students’ academic achievement in OTM. It was, therefore, suggested that OTM lecturers should include the use of Peer Tutoring Instructional Technique to boost learning in teaching their students.
The Effect of Pandemic Covid-19 into Internship Activity of Mojokerto Vocational High Schools
Authors: Setiyawan Andri , Kurniawan Arief 
Published: June 2021

This study aims to determine what steps were taken by the Vocational High School (SMK) 1 Mojokerto in implementing Dual System Education / Internship which is a mandatory activity for high school students to improve students` insights and qualities and foster good relations between a vocational high school and a job provider company during the COVID-19 pandemic. This research is qualitative research that aims to describe the implementation of Dual System Education / Internship by Vocational high School 1 Mojokerto during the COVID-19 pandemic. The Effect of Pandemic Covid-19 into Internship Activity on apprenticeship: 1) During the pandemic, halt the internship process; internship operations can resume after the pandemic has passed. (2) Relocating student street vendors to businesses that follow government and corporation laws and require the use of personal protective equipment (PPE). (3) Internships will be phased out in favor of online learning.