bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicopathological study of non-granulomatous necrotizing lymphadenopathies
Authors: Paul Tara Roshni , Ayesha Sobiya Mahnaz , Uppin Shantveer G , Uppin Megha S 
Published: December 2021

Non-granulomatous necrotizing lymphadenopathy (NGNL) is not a specific entity. It is seen in various conditions like Kikuchi-Fujimoto disease (KFD), Systemic Lupus Erythematosus (SLE), tuberculosis, lymphoma/metastasis and lymph node infarction. These conditions mimic each other histologically but it is necessary to identify the correct pathology as the treatment differs significantly. To highlight the subtle morphological features which lead to the etiological diagnosis in NGNL. The lymphnode biopsies (N=198), reported in our institute as NGNL, over 4½ year study period, were retrieved. Of these, the benign cases were 64 in total, with 40 cases of KFD and 8 cases of SLE. H&E, special stains and immunohistochemistry slides were reviewed by two pathologists. Histomorphological features like amount of necrosis, apoptotic debris, vasculitis, presence of neutrophils, eosinophils, histiocytes, plasma cells, hematoxylin bodies, Azzopardi phenomenon and thrombus formation were studied. Logistic regression analysis was performed to identify the most significant histopathological parameter with each disease. Kendall’s Tau matrix plot analysis was used to measure the correlation between the disease and the histopathologic variables. Features like vasculitis, hematoxylin bodies and Azzopardi phenomenon showed strong correlation with SLE and inverse correlation with KFD. Apoptotic debris, paucity of neutrophils and eosinophils had a strong positive association with KFD. The histological features help in differentiating the various entities associated with NGNL. It is necessary to correlate with clinical details and various laboratory parameters to reach a conclusive diagnosis because these conditions have varied treatment modalities.
Importance of fine needle aspiration cytology in revealing the spectrum of axillary swelling: An experience with 30 cases
Authors: Rai Tina , Rai G.S 
Published: December 2021

FNAC plays an important role in the early diagnosis of the axillary swelling. This study was conducted to document the spectrum of lesions on the patients that came for FNAC with the complain of axillary swelling. Present study was carried out at the Department of Pathology. A total of 30 cases of axillary swelling which were referred for FNAC in the department of Pathology, over the period of 3 months were retrospectively evaluated. All the stained slides of the cases were also reviewed.: From 30 cases there were 13 males and 17 females. On examining the stained slides maximum number of cases presented with chronic granulomatous lymphadenitis followed by Reactive lymphadenitis , Lipoma, Ductal carcinoma metastasis of breast in axillary lymphnode, chronic non-specific lymphadenitis, One unusual case of Hydatid cyst who presenting with axillary swelling was also diagnosed. : FNAC is an important tool in differentiating benign and malignant lesions thus, helps in the proper management of the disease.
Cyclin D1 expression in Peripheral T-Cell Lymphoma: A report of 2 cases
Authors: Rathi Shweta P , Pant Vinita , Mehta Jay 
Published: December 2021

: Peripheral T-cell lymphomas (PTCLs) represent a heterogeneous group of non-Hodgkin's lymphomas (NHL), characterized by poor outcome, accounting approximately for 10%-15% of all non-Hodgkin lymphomas in the western countries, and with a higher prevalence in Asia. Cyclin D1 immunoreactivity is characteristically seen in mantle cell lymphoma. It is also observed in hairy cell leukemia, plasma cell myeloma and a proportion of diffuse large B-cell lymphomas, however its expression in peripheral T-cell lymphoma is rarely recorded. : We report two cases of peripheral T-cell lymphoma not otherwise specified with heterogeneous nuclear Cyclin D1 immunohistochemical overexpression, due to gene copy gain, a phenomenon similar to that observed in Mantle Cell Lymphoma.: Cyclin D1 expression can be seen in PTCLs, besides mantle cell lymphoma, hairy cell leukemia and plasma cell myeloma and underline the importance of molecular biology integration tests as a diagnostic tool to escape the pitfall.
Tellegens dieren in het Poolse bos. De dubbele bodem en het visuele aspect bij Toon Tellegen in Poolse vertaling
Authors: Buelens Kaat 
Published: December 2021

This paper presents the results of a comparative analysis of two works by Dutch (children’s) author Toon Tellegen and their translations into Polish. The article focuses on the cultural context adaptation of the dual address for children and adults in his works on the one hand, the textual and visual cohesion on the other. The analysis will show that, while the translated text favors a foreignization approach, treating the child as a full-fledged reader and allowing the adult to find merit in these stories, too, the visual adaptations lean towards domesticating it for the Polish cultural context.
Het gebruik van “Oud en Nieuw Oost-Indiën” van François Valentyn door bewindhebbers van de VOC in de achttiende eeuw
Authors: Huigen Siegfried 
Published: December 2021

This article discusses the circulation of information extracted from François Valentyn’s Oud en Nieuw Oost-Indiën (1724–1726) during the eighteenth century, both with regards to the central organs of the Dutch East India Company (VOC) in the Netherlands and the VOC establishments in the East Indies. First, three documents are analysed that were part of five VOC directors’ personal archives, with the aim to determine the way these directors made use of Valentyn’s book. It is concluded that for these directors Oud en Nieuw Oost-Indiën was probably the most important source of information about the VOC’s trading empire, while at the same time their epistemic interest was limited to matters of trade. Second, the usage of Valentyn’s book in various VOC establishments in the East Indies is assessed on the basis of correspondence between these establishments with the VOC central government in Batavia. Because of the fact that Oud en Nieuw Oost-Indiën was used simultaneously as a source of information by several actors, both in the Netherlands and in the East Indies, this might have resulted in standardising the operational knowledge of the East Indies within the VOC network.
A Five-Year Review of Adverse Cutaneous Drug Reaction in a Tertiary Care Hospital in Yogyakarta, Indonesia
Authors: Oktarina Dyah Ayu Mira , Sophiati Maria , Moha Erinda Maharani Rambu , Waskito Fajar , Soebono Haryanto 
Published: December 2021

Background: The prevalence of adverse drug reactions is likely to increase, and it is associated with increased usage of various drugs. Adverse Cutaneous Drug Reaction (ACDR) is the most frequent adverse drug reaction (30–45%). In Indonesia, the study on the prevalence of ACDR is still limited. Purpose: This study investigated the prevalence, clinical features, causative agents, and mortality rate of ACDR with a type-IV hypersensitivity reaction among patients attending the Department of Dermatology and Venereology in Dr. Sardjito Hospital, Yogyakarta. Methods: This retrospective study was conducted examining medical records undertaken for five years (2011–2015). Of 68,375 patients medicated in the Department of Dermatology and Venereology, 397 patients were diagnosed as ACDR with a type-IV hypersensitivity reaction. Detailed history, including age, sex, past history, and family history of drug reaction taken by the patient, were obtained. Patch testing was done wherever feasible. Result: Of 68,375 patients, 397 patients were included in ACDR with type-IV hypersensitivity (0.58%), giving a 5% of mortality rate. The mean age of the patients was 40.42 years (±16.30; range 18 to 89 years). The female to male ratio was 1.1: 1. The Maculopapular rash was the most common ACDR manifestation (50.88%), followed by Stevens-Johnson Syndrome (13.85%), Fixed Drug Eruption (12.85%), and Drug Reaction with Eosinophilia and Systemic Symptoms (10.08%). The most common causative agents were beta-lactam (16.55%), NSAIDs (12.18%), and acetaminophen (8.62%). Conclusion: Prescription of those drugs should be considered carefully so the incidence of ACDR can be reduced.
UPAYA MENINGKATKAN KEAKTIFAN SISWA DALAM PROSES PEMBELAJARAN
Authors: Murni Neli Fitra 
Published: December 2021

<em>Pendidik perlu memahami setiap karakter siswa dalam menerima pembelajaran dan mampu mendorong siswa supaya aktif selama proses pembelajaran agar penyampaian materi atau proses pembelajaran menjadi lancar dan sukses sehingga tercapainya tujuan pembelajaran. Pendidik juga perlu memahami upaya-upaya yang harus dilakukan untuk merangsang keatifan siswa dalam proses pembelajaran.Tujuan kajian ini adalah untuk (1) mendeskripsikan keaktifan siswa dalam belajar; (2) mendeskripsikan ciri-ciri siswa aktif; (3) mendeskripsikan upaya- upaya yang dilakukan untuk meningkatkan keaktifan siswa dalam belajar. Hasil penelitian ini adalah sebagai berikut: (1) Siswa aktif adalah siswa yang secara terus menerus berpartisipasi secara fisik, psikis, intelektual dan emosional, membentuk suatu proses membandingkan materi yang diterima; (2) Ciri-ciri siswa aktif adalah: a. berani mengeluarkan pendapat, kemauan serta kehendaknya dan berupaya melaksanakan kegiatan pembelajaran, b. Ikut serta pada saat persiapan, pemprosesan dan kelanjutan kegiatan pembelajaran hingga menginformasikan nilai pembelajaran, c. menunjukan upaya pembelajaran yang berbeda guna mencapai keberhasilan (pembelajaran kreatif), d. belajar mencari dan menemukan sendiri ilmu pengetahuan yang di dapat. (3) Upaya yang dapat dilakukan untuk meningkatkan pembelajaran siswa dapat menggunakan pembelajaran kooperatif, media interaktif, video pembelajaran, dan metode diskusi.</em>
The Effect of Steaming Time on the Textural Characteristics of Two Sweet Potatoes with Different Flesh Colors
Authors: Utomo Joko Susilo , Ginting Erliana 
Published: December 2021

<p>Sweet potatoes have varied physical characteristics based on their flesh colors. Two selected sweet potato (SP) with white (WF) and yellow-fleshed (YF) colors were collected from local market and analyzed their textural characteristics using a Uniaxial compression and Texture Profile Analysis (TPA) test. The study was conducted in the Food Processing Technology Laboratory, Faculty of Food Science Technology, University of Putra Malaysia. All textural attributes were collected from the samples treated with steaming for 5, 10, 15 and 20 min. The moisture content of the samples were determined before and after steaming. The results showed that the moisture content of WF was lower than YF both before and after steaming, which could be declared as a typical moisture content for each flesh color. This resulted in a greater peak deformation or firmness of the fresh tuber found in WF relative to YF. Steaming SP for 5 min exhibited the “raw” properties tissue, whereas steaming for more than 10 min would generate the “cooked” tissue that significantly affected the textural characteristics. The hardness level decreased considerably along with the time of steaming and was similar for both flesh colors after 15-min steaming. The WF was less adhesive and less elastic; however, it had less chewiness than that of YF. This suggests that the use of WF as a raw material for mashed products would have advantages, such as easiness to mash, less tendency to stick with the cooking tools, and less elastic. <br /><br /></p>
Keragaan Fisiologis dan Morfologis Dua Kultivar Kedelai Asal Subtropis dan Tropis Akibat Cekaman Kekeringan
Authors: Soleh Mochamad Arief , Manggala Ranu , Kadapi Muhamad 
Published: December 2021

<p>Strategi untuk memperbaiki sifat pertumbuhan tanaman budidaya adalah dengan melakukan penelusuran sifat tumbuh tanaman baik secara morfologi dan fisiologi. Penelitian ini bertujuan untuk membandingkan keragaan pertumbuhan kultivar kedelai asal subtropis yaitu Tambaguro dengan kedelai asal tropis yaitu Anjasmoro yang diberi cekaman kekeringan. Penelitian di lakukan di daerah tropis yaitu di Kelurahan Pasirwangi, Ujung Berung, Bandung menggunakan pot. Pertumbuhan tinggi tanaman kedelai kultivar Tambaguro berkisar 12 cm pada umur 2 MST (minggu setelah tanam) sampai 29 cm pada umur 6 MST, sedangkan tinggi tanaman kultivar Anjasmoro berkisar 10 cm pada 2 MST sampai 32 cm pada 6 MST. Tampilan konduktasi stomata untuk kedua kultivar menunjukkan penurunan seiring umur tanaman (2-6 MST) yaitu berkisar 1094 - 1042 mmol/m²•s untuk Tambaguro, dan 892-1319 mmol/m²•s untuk Anjasmoro. Kultivar Tambaguro memperlihatkan pertumbuhan tinggi tanaman lebih baik dari kultivar Anjasmoro pada awal tumbuh, namun tidak pada pertumbuhan umur lanjut, sedangkan Kultivar Anjasmoro memiliki keunggulan dalam pertumbuhan tinggi pada umur lanjut. Tampilan fisiologis berupa respons konduktansi stomata dan fluoresensi klorofil kultivar Tambaguro lebih baik dari Anjasmoro disemua umur pengamatan, sedangkan dalam kodisi cekaman kekeringan, tampilan fisiologis kedua kultivar cenderung sama menunjukkan ada potensi keunggulan genetik yang perlu dipertimbangkan, terlebih kultivar Tambaguro ini merupakan jenis kedelai berbiji besar sehingga memiliki keungulan secara ekonomis.<br /><br /></p><p>Kata Kunci: </p>
Scalable Graphics Processing Unit–Based Multiscale Linear Solvers for Reservoir Simulation
Authors: Manea A. M. , Almani T. 
Published: December 2021

Summary
In this work, the scalability of two key multiscale solvers for the pressure equation arising from incompressible flow in heterogeneous porous media, namely, the multiscale finite volume (MSFV) solver, and the restriction-smoothed basis multiscale (MsRSB) solver, are investigated on the graphics processing unit (GPU) massively parallel architecture. The robustness and scalability of both solvers are compared against their corresponding carefully optimized implementation on the shared-memory multicore architecture in a structured problem setting. Although several components in MSFV and MsRSB algorithms are directly parallelizable, their scalability on the GPU architecture depends heavily on the underlying algorithmic details and data-structure design of every step, where one needs to ensure favorable control and data flow on the GPU, while extracting enough parallel work for a massively parallel environment. In addition, the type of algorithm chosen for each step greatly influences the overall robustness of the solver. Thus, we extend the work on the parallel multiscale methods of Manea et al. (2016) to map the MSFV and MsRSB special kernels to the massively parallel GPU architecture. The scalability of our optimized parallel MSFV and MsRSB GPU implementations are demonstrated using highly heterogeneous structured 3D problems derived from the SPE10 Benchmark (Christie and Blunt 2001). Those problems range in size from millions to tens of millions of cells. For both solvers, the multicore implementations are benchmarked on a shared-memory multicore architecture consisting of two packages of Intel® Cascade Lake Xeon Gold 6246 central processing unit (CPU), whereas the GPU implementations are benchmarked on a massively parallel architecture consisting of NVIDIA Volta V100 GPUs. We compare the multicore implementations to the GPU implementations for both the setup and solution stages. Finally, we compare the parallel MsRSB scalability to the scalability of MSFV on the multicore (Manea et al. 2016) and GPU architectures. To the best of our knowledge, this is the first parallel implementation and demonstration of these versatile multiscale solvers on the GPU architecture.
NOTE: This paper is also published as part of the 2021 SPE Reservoir Simulation Conference Special Issue.
Climate change and deforestation drive the displacement and contraction of tropical montane cloud forests
Authors: Ramírez-Barahona Santiago , Cuervo-Robayo Ángela P. , Feeley Kenneth , Ortiz-Rodríguez Andrés , Vásquez-Aguilar Antonio , Ornelas Juan Francisco , Rodríquez-Correa Hernando 
Published: December 2021

Abstract
Global climate change and habitat loss are displacing tropical montane forests along mountain slopes1–4. Cloud forests are one of the most diverse and fragile of these montane ecosystems5–8, yet little is known about the historical and ongoing impacts of anthropogenic disturbances on these forests. Here we assess historical (1901–2016) changes in the altitudinal range of vascular plant species in Mesoamerican cloud forests and evaluate the relative impacts of climate change and land-use alterations. By analysing thousands of occurrence records from public biological collections, we uncovered common altitudinal shifts across species and suggest an overall contraction of cloud forests starting in the late 1970s. We infered a pervasive and interrelated impact of rising temperatures, changing precipitation patterns, and deforestation on the distribution of cloud forest species across Mesoamerica. Over the last fifty years, cloud forests have declined due to deforestation and warmer and more (seasonally) arid climates9–11. This is pushing species’ to contract their altitudinal ranges and may lead to an increasing probability of abrupt and devastating declines of population sizes, local adaptation, and migration.
Novel Genome-wide Interactions Mediated via BOLL and EDNRA Polymorphisms in Intracranial Aneurysm
Authors: Hong Eun Pyo , Youn Dong Hyuk , Kim Bong Jun , Lee Jae Jun , Nam Sehyeon , Yoo Hyojong , Park Jeong Jin , Cho Yong Jun , Jeon Jin Pyeong 
Published: December 2021

Abstract
Association of boule (BOLL) and endothelin receptor type A (EDNRA) loci with intracranial aneurysm (IA) formation has been reported via genome-wide association studies. However, the underlying genome-wide interactions have yet to be reported. We sought to identify genome-wide interactions involving BOLL and EDNRA loci for IA. Genome-wide interaction analyses of BOLL and EDNRA involving 250 IA patients and 296 controls were performed under an additive effect model. Subsequent gene expression analyses were conducted using transcripts per million (TPM). A total of 23 and 11 SNPs suggested a genome-wide threshold (p < 1.25×10−8) interacting with rs700651 (BOLL) and rs6841581 (EDNRA), respectively. The rs1105980 (PTCH1) showed the most significant interaction with rs700651 (p = 6.41×10−11). The rs74585958 (RYK) interacted strongly with rs6841581 (p = 1.64×10−9). The BOLL-interacting CXCR4 was highly overexpressed in whole blood (TPM = 419.8) and CCDC3 was overexpressed in all artery-related tissues (TPM = 315.4 to 473.9). EDNRA-interacting EIF4H showed a comprehensively elevated expression across all tissues and cells (TPM = 85.8 to 372.0). Genome-wide interaction study shows that BOLL and EDNRA may contribute to IA formation by interacting with multiple genes in cardio-metabolic pathway. Our findings may provide insight into the functional relevant to IA susceptibility.
Spatiotemporal Quantification of Metastatic Tumour Cell Growth and Distribution in Lymph Nodes by Whole-Mount Tissue 3D Imaging
Authors: Zhang Zhi-Gang , Li Jun , Xu Chun-Jie , Tian Guang-Ang , Li Qing , Li Dong-Xue , Yan Fang , Wang Xu , Jiang Shu-Heng , Wang Ya-Hui , Zhou Yao-Qi , Song Jian , Zhang Xue-Li , Xu Qing , Hu Li-Peng , Li Xiaowei 
Published: December 2021

Abstract
Lymph nodes (LNs) are a common site of metastasis in many solid cancers. Tumour cells can migrate to LNs for further metastatic colonization of distant organs, indicating poor prognosis and requiring different clinical interventions. The current histopathological diagnostic methods used for the detection of clinical lymph node metastasis (LNM) still have some limitations, such as incomplete observation. To obtain a complete picture of tumour-metastasized LNs at spatial and temporal scales, we used 3D imaging of solvent-cleared organs (uDISCO) and 3D rapid immunostaining. MC38 cells tagged with EGFP were injected into the left footpad of C57BL/6 mice. Draining lymph nodes (DLNs) obtained from these mice were cleared using uDISCO. Metastatic colorectal cancer (CRC) cells in various regions of DLNs from mice at different time points were quantified using whole-mount tissue 3D imaging. The results revealed several stages of tumour cell growth and distribution in LNs: 1) invasion of lymphatic vessels (LVs) and blood vessels (BVs); 2) dispersion outside LVs and BVs for proliferation and expansion; and 3) re-entry into BVs and efferent lymphatic vessels (ELVs) for further distant metastasis. Moreover, these data demonstrated that mouse fibroblast cells (MFCs) could not only promote the LNM of tumour cells but could also metastasize to LNs together with tumour cells, thus providing a “soil” for tumour cell colonization. In conclusion, whole-mount tissue 3D imaging and spatiotemporal analysis of LNM may together constitute an auxiliary method to improve the accuracy of clinical LNM detection in the future.
Efficacy and tolerability of Native CT-II® on modulating knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled trial
Authors: Luo Cheng , Srivast Shalini 
Published: December 2021

Abstract
Background
Osteoarthritis (OA) of the knee is the most common type of arthritis, increasing with advancing age and external factors such as obesity. Joint health has historically relied on nutritional supplements derived from herbs and other natural products. Undenatured collagen type II demonstrated positive results with substantially lower therapeutic doses. Hence, the present study was designed to determine the efficacy and safety of Native CT-II®, an undenatured type II collagen, on the symptomatic effects in individuals having joint pain due to OA.
Methods
A randomized, double-blinded, placebo-controlled, parallel study was conducted on 101 slightly overweight volunteers, whose knee joint pain VAS score was ≥ 60 had been included in the study for at least three months. The participants were divided into three groups, with similar demographic and baseline characteristics. The test product containing Native CT-II®, positive control containing G+C, and the placebo were taken six tablets per day for 84 consecutive days (Three capsules to be taken post-breakfast and three capsules post-dinner). Improvement in overall joint health in each participant from baseline to end of the study was measured by WOMAC, self-administered questionnaire in Native CT-II® as compared to G+C and placebo group.
Results
This study demonstrated that Native CT-II® had an effective impact on the symptomatic effects of knee impairment associated with OA and in the quality of life of the participants. After 84 days, participants receiving Native CT-II® and G+C had significant improvement in overall joint health as compared to participants receiving placebo.
Conclusion
Native CT-II® was shown to be effective in relieving symptoms and improving quality of life for patients with knee joint pain associated with OA.
Trial registration:
The trial was registered with the clinical trial registry of the U.S. National Library of Medicine under National Institutes of Health (NIH) (https://clinicaltrials.gov/) with the National Clinical Trial (NCT) No: NCT04470336, Date of first registration: 14/07/2020.