bluuebunny/crossref_metadata_2025_split huggingface dataset:
On a fractional cantilever beam model in the q-difference inclusion settings via special multi-valued operators
Authors: Etemad Sina , Hussain Azhar , Imran Atika , Alzabut Jehad , Rezapour Shahram , Selvam A. George Maria 
Published: October 2021

AbstractThe fundamental goal of the study under consideration is to establish some of the existence criteria needed for a particular fractional inclusion model of cantilever beam in the setting of quantum calculus using new arguments of existence theory. In this way, we investigate a fractional integral equation that corresponds to the aforementioned boundary value problem. In a more concrete sense, we design new multi-valued operators based on this integral equation, which belong to the certain subclasses of functions, called α-admissible and α-ψ-contractive multi-functions, in combination with the AEP-property. Also, we use some inequalities such as Ω-inequality and set-valued version inequalities. Moreover, we add a simulative example for a numerical analysis of our results obtained in this study.
Risk factors for colonization with multiple species of extended-spectrum beta-lactamase producing Enterobacterales: a case-case–control study
Authors: Vock Isabelle , Aguilar-Bultet Lisandra , Egli Adrian , Tamma Pranita D. , Tschudin-Sutter Sarah 
Published: October 2021

Abstract
Background
Approximately 11% of patients colonized with extended-spectrum beta-lactamase producing Enterobacterales (ESBL-PE) are colonized with more than one ESBL-producing species. We investigated risk factors associated with colonization with multiple ESBL-PE species.

Methods
We performed a case-case–control study at the University Hospital Basel, Switzerland, including hospitalized patients colonized with ESBL-PE between 01/2008 and 12/2018. Patients colonized with multiple species of ESBL-PE during the same hospitalization were assigned to group 1. Group 2 consisted of patients with ESBL-PE and a newly acquired ESBL-PE-species identified during subsequent hospitalization. Controls (i.e., group 3) were patients with only one species of ESBL-PE identified over multiple hospitalizations. Controls were frequency-matched 3:1 to group 2 cases according to time-at-risk (i.e., days between ESBL-PE detection during first and subsequent hospitalizations) to standardize the duration of colonization. ESBL was identified with phenotypic assay and the presence of ESBL genes was confirmed by whole genome sequencing.

Results
Among 1559 inpatients, 154 cases met eligibility criteria (67 in group 1, 22 in group 2, 65 in group 3). International travel within the previous 12 months (OR 12.57, 95% CI 3.48–45.45, p < 0.001) and antibiotic exposure within the previous 3 months (OR 2.96, 95% CI 1.37–6.41, p = 0.006) were independently associated with co-colonization with multiple ESBL-PE species. Admission from another acute-care facility was the only predictor of replacement of one ESBL-PE species with another during subsequent hospitalizations (OR 6.02, 95% CI 1.15–31.49, p = 0.003).

Conclusion
These findings point to strain-related factors being the main drivers of co-colonization with different ESBL-PE and may support stratification of infection prevention and control measures according to ESBL-PE species/strains.
An updated calculator for determining levodopa-equivalent dose
Authors: Nyholm D. , Jost W. H. 
Published: October 2021

AbstractCalculation of levodopa-equivalent dose in Parkinson’s disease has become common in research, but is also a useful tool in clinical practice, especially when initiating device-aided treatments (deep brain stimulation, apomorphine and levodopa infusions). The aim with the present calculator is to provide an updated conversion table, including dose calculation of the recently developed levodopa/entacapone/carbidopa intestinal gel infusion. Future versions of the calculator should be made conducive to learning by means of artificial intelligence.
SGLT2 inhibitors in heart failure with reduced ejection fraction
Authors: Das Uday Sankar , Paul Aritra , Banerjee Suvro 
Published: October 2021

AbstractSodium – glucose co-transporter 2 (SGLT2) inhibitors reduce blood glucose by inhibiting reabsorption of glucose from the proximal renal tubules. Initial studies showed that apart from reducing blood glucose they also reduce the combined endpoint of myocardial infarction, stroke, and cardiovascular death, hospitalization from heart failure, and occurrence of renal failure in patients with known cardiovascular disease or at high risk of developing cardiovascular disease. Recent studies have shown that these drugs also could be used in patients to treat heart failure or to slow the progression of renal failure, irrespective of whether the patients have diabetes or not. In this review, we discuss the clinical trial evidence for the use of SGLT2 inhibitors for the treatment of patients with heart failure with reduced ejection fraction and for the prevention of heart failure in patients with diabetes who are at high risk of cardiovascular events. We also discuss the plausible mechanisms of action for the cardiovascular beneficial effects of SGLT2 inhibitors. EMPA-REG OUTCOME TRIAL, DECLARE-TIMI 58, CANVAS, VERTIS-CV studies have shown that SGLT2 inhibitors namely empagliflozin, dapagliflozin, canagliflozin and ertugliflozin reduce the chances of hospitalisation in patients who have cardiovascular disease or at high risk of cardiovascular disease. The DAPA-HF study and the EMPEROR-REDUCED TRIAL have further shown that Dapagliflozin and Empagliflozin could be used to treat patients with heart failure, with or without diabetes. SGLT2 inhibitors provide us with a new armamentarium for treatment of patients with a triad of diabetes, heart or renal disease. Their mechanism of action in prevention or treatment of patients with heart failure however still remains speculative.
Mejora continua al Sistema de Aseguramiento de la Calidad de las auditorías internas
Authors: Solano-Cruz Giovanni 
Published: October 2021

Esta investigación tiene un enfoque cuantitativo y es tipo descriptivo. Se aplica a los auditores internos y personal técnico colaborador de 22 Unidades de Auditoría Interna gubernamentales, un cuestionario de 44 preguntas dividido en las tres variables que sustentan la investigación: metodología de las Unidades de Auditoría Interna para el aseguramiento de la calidad; aplicación del marco normativo y mejoras prácticas; y fortalezas y debilidades de las Unidades de Auditoría Interna. Los resultados muestran que las auditorías internas están conformadas por personal que reúne los requisitos académicos y experiencia; sin embargo, se debe mejorar la calidad del trabajo, implementando recomendaciones como la medición y análisis de los indicadores de gestión, inclusión de auditorías operativas en el plan anual de trabajo, implementación de mejores prácticas mundiales, uso de herramientas tecnológicas, identificación de riesgos, capacitación profesional continua, adopción de un sistema de gestión de la calidad, etc.
Evolução dos índices de saneamento básico no município de Arapongas-PR
Authors: Anklam Fernanda Roberta , Camilo Rodrigo , Battistelli André Aguiar 
Published: October 2021

O saneamento básico contempla os serviços relacionados à quatro pilares: distribuição de água, coleta e tratamento de esgotos, drenagem urbana e gerenciamento de resíduos sólidos. Tais serviços devem ser disponibilizados à população para a garantia de uma adequada qualidade de vida, sobretudo no que tange à saúde pública, em especial no cenário de pandemia. Tal condição evidencia a importância de se acompanhar a evolução da oferta destes serviços à população, auxiliando na definição de ações e tomada de decisões. Nesse contexto, este estudo teve como objetivo analisar os indicadores da prestação de serviços de saneamento e seus reflexos na saúde da população do município de Arapongas-PR, com foco no abastecimento de água e esgotamento sanitário. Aplicou-se uma metodologia de pesquisa descritiva com abordagem quali-quantitativa, com a compilação de dados secundários no período referente a 2010 e 2018, disponíveis em plataformas e documentos de livre acesso. Constatou-se que o crescimento urbano foi acompanhado por uma evolução na oferta de serviços de saneamento, permanecendo constante a marca de 100% de atendimento à população com abastecimento de água, e aumentando de forma progressiva no atendimento relacionado a coleta e tratamento de esgoto sanitário. Verificou-se, ainda, que os índices de saúde evoluíram no mesmo período, reduzindo despesas e taxas de internações com doenças relacionadas a falta de saneamento. Concluiu-se que os investimentos realizados em saneamento, refletiram diretamente na qualidade de vida da população do município de Arapongas - PR.
Adoção de Inteligência de Negócio e Big Data Analytics (BDA) e Retorno sobre Investimento: Um Estudo no Setor de Consumo Não Cíclico Listadas na B3 (Brasil-Bolsa-Balcão)
Authors: Dieng Mamadou , DA ROCHA MARIA ELOISA RODRIGUES MOURA 
Published: October 2021

O estudo parte do pressuposto teórico da Visão Baseada em Recursos (VBR) de que empresas que possuem recursos de Tecnologia da Informação (TI) tal como Big Data e fazem sua aplicação tendem a criar valor ao negócio e conseguem obter maiores suas taxas de retorno sobre o investimento (ROI). Neste contexto, o objetivo do estudo é identificar o uso de big data pelas empresas listadas no setor de consumo não cíclico da B3 (Brasil-Bolsa-Balcão). Para tanto, foram analisadas 25 empresas que compõem esse setor. A pesquisa classifica-se como quali-quanti e caracteriza-se como exploratória e descritiva. Os dados da pesquisa foram coletados através de relatórios de apresentação institucional, de sustentabilidade, relatórios integrados, trimestrais e anuais. Para categorizar os dados da pesquisa segundo os construtos aplicações, dados, analíticos e impactos, utilizou-se o formulário adaptado de Chen, Chain e Storey (2012) e o tratamento dos dados se deu por meio da análise descritiva que explorou a descrição dos construtos do formulário na amostra pesquisada e a análise inferencial a partir do teste não paramétrico U de Mann-Whitney. Os achados apontam parcialmente que a adoção de capacidade ou recursos pode criar valor às empresas, nesse sentido. Esses resultados corroboram com os achados de Krishnamoorthi e Mathew (2018), de que os recursos tecnológicos de big data podem contribuir para gerar informações que adicionam valor à empresa, ou seja, que melhoram a rentabilidade dos investimentos. Essa evidência é suportada também pelo estudo de Bharadwaj (2000), em que, foi descoberto que as empresas com alta capacidade de TI tendem a superar uma amostra de empresas de controle em uma variedade de lucro e medidas de desempenho baseados nos custos, o que é determinante para a maximização da margem de lucro da empresa e assim a rentabilidade dos investimentos.
Comparative Analysis of Molecular-Genetic Properties in Non-Toxigenic Vibrio cholerae O1 Strains Biovar El Tor, Isolated in Russia and on Cholera Endemic Territories
Authors: Kritsky A. A. , Smirnova N. I. , Kalyaeva T. B. , Obrotkina N. F. , Gracheva I. V. , Katyshev A. D. , Kutyrev V. V. 
Published: October 2021

Objective of the study was to perform a comparative analysis of molecular-genetic properties in non-toxigenic Vibrio cholerae O1 strains biovar El Tor, isolated in the Republic of Kalmykia and on cholera endemic territories and to reveal their phylogenetic relations to toxigenic isolates.Materials and methods. We have carried out bio-information analysis of whole genome sequences of 60 cholera vibrio strains from endemic as regards cholera regions and from Kalmykia. The presence of pathogenicity and endemicity islands in their genomes has been determined. Specifed have been the sequence-types of the examined strains and whole genome SNP-analysis conducted.Results and discussion. Non-toxigenic El Tor vibrios circulating in Kalmykia are clustered into two major genotypes: ctxA–tcpA+VPI-2+VSP– and ctxA–tcpA–VPI-2Δ+VSP–, where VPI-2 Δ+ signifes the presence of deletions of varying length in the genome of this pathogenicity island. Only the latter one is found in regions endemic for cholera. In addition, ctxA– tcpA+VPI-2+VSP+ populations circulate in cholera endemic foci, not found in Kalmykia. 17 sequence-types were identifed among the studied strains (by seven housekeeping gene loci). Phylogenetic analysis performed using SNP-typing demonstrated the absence of close genetic relation between the ctxA–tcpA+VPI-2+VSP– vibrios from Kalmykia and both toxigenic and non-toxigenic vibrios with diﬀerent composition of pathogenicity and pandemicity islands in the genome. At the same time, genetic proximity of ctxA–tcpA–VPI-2Δ+VSP– cholera vibrios from endemic cholera foci with those isolated in Kalmykia was detected, which may indicate the possibility of their recurrent importation into the territory of Russia. Non-toxigenic V. cholerae strains found in the territory of Kalmykia are characterized by a high genetic diversity. Circulation of the strains with unique sequence-types suggests their potential for long-term persistence on this territory. At the same time, phylogenetic closeness and identity of certain strains with strains from endemic territories can be an evidence of repeated importation.
Cerebrospinal Fluid Biomarker Levels as Markers for Nursing Home Placement and Survival Time in Alzheimer’s Disease
Authors: Wattmo Carina , Blennow Kaj , Hansson Oskar 
Published: October 2021

Background:
Cerebrospinal Fluid (CSF) biomarkers are associated with conversion
from mild cognitive impairment to Alzheimer’s Disease (AD), but their predictive value for later
end-points has been less evaluated with inconsistent results.

Objective:
We investigated potential relationships between CSF amyloid-β1-42 (Aβ42), Phosphorylated
tau (P-tau), and Total tau (T-tau) with time to Nursing Home Placement (NHP) and life expectancy
after diagnosis.

Methods:
This prospective observational study included 129 outpatients clinically diagnosed with
mild-to-moderate AD who underwent a lumbar puncture. The CSF biomarkers were analysed with
xMAP technology. Dates of institutionalisation and death were recorded.

Results :
After 20 years of follow-up, 123 patients (95%) were deceased. The participants with abnormal
P-tau and T-tau (A+ T+ (N)+) died earlier than those with normal P-tau/abnormal T-tau
(A+ T- (N)+) (mean, 80.5 vs. 85.4 years). Linear associations were demonstrated between lower
Aβ42 and shorter time to NHP (p = 0.017), and higher P-tau and younger age at death (p = 0.016).
No correlations were detected between survival after AD diagnosis and CSF biomarkers. In sexand-
age-adjusted Cox regression models, higher P-tau and T-tau were independent predictors of
shorter lifespan after diagnosis. In multivariate Cox models, older age and lower baseline cognitive
status, but not elevated tau, significantly precipitated both institutionalisation and death.

Conclusion:
These findings suggest that CSF biomarker levels plateau in the dementia phase of
AD, which may limit their possible relationships with clinical end-points, such as NHP and survival
time. However, the biomarkers reflect the central pathophysiologies of AD. In particular, pathologic
tau is associated with more advanced disease, younger age at onset, and earlier death.
An Overview of C19MC Cluster Subgroup 3 and Cancer
Authors: Fonseca Ángela Y. García , Santos Janneth Gonzalez , Aristizábal-Pachón Andrés Felipe 
Published: October 2021

:
The primate-specific microRNA gene cluster on chromosome 19 (C19MC) is composed
of 56 mature microRNAs (miRNAs), which are divided into three subgroups according to the sequence
similarity. This cluster is principally expressed in the placenta but not in other tissues.
C19MC is involved in the regulation of proliferation, migration, and invasion of trophoblastic
cells, which are important for the development of the placenta. There is a growing number of
studies that have found an altered expression of some miRNAs of the C19MC cluster in cancer,
suggesting that these could play an important role in the development of this disease. Therefore, in
this work, we provided an overview of the C19MC cluster's role in cancer through a systematic review
of published articles. In particular, we focused on miRNAs of subgroup 3. These studies
suggest that miRNAs such as miR-512-3p, miR-512-5p, miR-516a-5p, miR-516b-5p, and
miR-498-5p could play a pivotal role in the development of therapies for cancer. Future studies are
necessary to elucidate the molecular processes and pathways regulated by subgroup 3 miRNAs.
Trends in Empirical Treatment of Hospitalized Children with Acute Gastroenteritis in Nigeria
Authors: David Ebuka E. , Igwenyi Ikechuku O. , Iroha Ifeanyichukwu R. , David Chidinma N. , Mbah Precious C. , Okpala Ogochukwu F. , Ukeh Nkemdirim U. , Ogbaji Oluchukwu , Ugwurauma Chinecherem E. , Chukwuma Goodness C. 
Published: October 2021

Background:
Acute gastroenteritis is a common infectious disease
with a high rate of morbidity and mortality in children below five years of age.
Appropriate empirical treatment is therefore vital for reducing the incidence of
the disease.

Objective:
This study aimed at determining the trends in the empirical treatment
of hospitalized children with acute gastroenteritis.

Method:
The study involved the data analysis of 88 medical folders of children
who were diagnosed with gastroenteritis from January to February 2020 (a period
of gastroenteritis yearly outbreak) in Mile 4 Hospital Abakaliki, Ebonyi State,
Nigeria. Socio-demographic data and administered antibiotics data were collected.

Result:
Out of the 88 children, a total of 54 (61%) children were males, while
34 (39%) were females. The ages of the children ranged between 1-51 months,
while the mean age was seen at 14 months. About 58 (66%) were diagnosed with
acute gastroenteritis alone, with children aged 7-12 months recording higher numbers
[25 (28%)]. Severe dehydration was seen as the most common morbidity of
children with acute gastroenteritis. The guardians/parents of these children
stayed at home for an average of 3 days (1-6 days) before visiting the hospital.
The children were treated for an average of 5 days (2-9 days) in the hospital. The
most singly used antibiotics was ciprofloxacin [31 (35%)] followed by a combination
of ciprofloxacin and ceftriaxone [21 (24%)]. About 12 (14%) of the children
were treated using a single dose of the antimalarial drug while 10 (11%)
were treated in double combination therapy. The lowest duration in hospitalization
(4 days) was seen in the use of a single dose regimen, while the highest hospitalization
time (6 days) was seen in the use of a triple dose regimen.

Conclusion:
The best empirical treatment of acute gastroenteritis may involve
the use of ciprofloxacin alone and its combination with ceftriaxone. The severity
of gastroenteritis may also be exacerbated with malaria.
ANALISIS MANAJEMEN PENGGUNAAN DANA BANK BERDASARKAN USE OF FUND BY PRIORITY DALAM MENGOPTIMALKAN PROFITABILITAS PERBANKAN SYARIAH DI INDONESIA
Authors: Bustam Nur Hasanah 
Published: October 2021

Penelitian ini untuk mengetahui pengaruh manajemen penggunaan dana berdasarkan sisi prioritas (Use of Funds by Priority) dalam meningkatkan profitabilitas perbankan syariah di Indonesia dari tahun 2011-2015 . Jumlah sampel dalam penelitian ini ada 12 Bank Umum Syariah dan 22 Unit Usaha Syariah. Metode analsis data yang digunakan adalah analisa regresi linier berganda dengan pengujian asumsi klasik dan pengujian hipotesis dari uji F, uji-t dan uji R2. Berdasarkan uji F dihasilkan bahwa secara simultan variabel penempatan dana pada giro wadhiah di BI, penempatan dana pada SWBI/SBIS, penempatan dana pada bank syariah lain, pembiayaan mudharabah, pembiayaan murabahah, dan investasi surat berharga berpengaruh signifikan terhadap profitabilitas bank syariah di Indonesia. Sedangkan secara parsial dengan uji-t dihasilkan bahwa penempatan dana Giro Wadhiah pada BI, penempatan dana pada bank syariah lain, dan investasi pada surat berharga tidak berpengaruh terhadap profitabilitas perbankan syariah di Indonesia. Sementara penempatan dana pada SWBI/SBIS dan pembiayaan mudharabah berpengaruh negatif signifikan terhadap profitabilitas perbankan syariah di Indonesia. Sedangkan pembiayaan murabahah berpengaruh positif signifikan terhadap profitabilitas perbankan syariah di Indonesia. Berdasarkan uji R2dihasilkan bahwa kontribusi variable independent terhadap variabel dependent sebesar 68,9% sedangkan sisanya 31,1% dipengaruhi oleh factor lain yang tidak termasuk dalam penelitian ini.Penelitian ini untuk mengetahui pengaruh manajemen penggunaan dana berdasarkan sisi prioritas (Use of Funds by Priority) dalam meningkatkan profitabilitas perbankan syariah di Indonesia dari tahun 2011-2015 . Jumlah sampel dalam penelitian ini ada 12 Bank Umum Syariah dan 22 Unit Usaha Syariah. Metode analsis data yang digunakan adalah analisa regresi linier berganda dengan pengujian asumsi klasik dan pengujian hipotesis dari uji F, uji-t dan uji R2. Berdasarkan uji F dihasilkan bahwa secara simultan variabel penempatan dana pada giro wadhiah di BI, penempatan dana pada SWBI/SBIS, penempatan dana pada bank syariah lain, pembiayaan mudharabah, pembiayaan murabahah, dan investasi surat berharga berpengaruh signifikan terhadap profitabilitas bank syariah di Indonesia. Sedangkan secara parsial dengan uji-t dihasilkan bahwa penempatan dana Giro Wadhiah pada BI, penempatan dana pada bank syariah lain, dan investasi pada surat berharga tidak berpengaruh terhadap profitabilitas perbankan syariah di Indonesia. Sementara penempatan dana pada SWBI/SBIS dan pembiayaan mudharabah berpengaruh negatif signifikan terhadap profitabilitas perbankan syariah di Indonesia. Sedangkan pembiayaan murabahah berpengaruh positif signifikan terhadap profitabilitas perbankan syariah di Indonesia. Berdasarkan uji R2 dihasilkan bahwa kontribusi variable independent terhadap variabel dependent sebesar 68,9% sedangkan sisanya 31,1% dipengaruhi oleh factor lain yang tidak termasuk dalam penelitian ini.
Digital Twin for Power Plants, Energy Savings and other Complex Engineering Systems
Authors: Sleiti Ahmad K. , Kapat Jayanta S. , Vesely Ladislav , Al-Khawaja Mohammed 
Published: October 2021

Digital Twin (DT) is a digital representation of a machine, service, or production system that consists of models, information, and data used to characterize properties, conditions, and behavior of the system. Renewable energy integration will make future power plants more complex with addition of varieties of Power-to-X technologies, Electrolysis to green hydrogen, onsite storage and transport of hydrogen, and use of pure or blended hydrogen, etc. These future power plants need robust DT architecture to achieve high Reliability, Availability and Maintainability at lower cost. In this research work, a comprehensive and robust DT architecture for power plants is proposed that also can be implemented in other similar complex capital-intensive large engineering systems. The novelty and advantages of the proposed DT is asserted by reviewing the state-of-the-art of DT in energy industries and its potential to transform these industries. Then the proposed DT architecture and its five components are explained and discussed. More specifically, the main contributions of the present work include: 1.	Overview of DT key research and development for energy savings applications to consider important findings, research gaps and the needed future development for the proposed DT for power plants. 2.	Overview of DT key research for power plants including applications, frameworks and architectures to consider important findings and to confirm the novelty and robustness of the proposed DT. 3.	Proposing and demonstrating new robust DT architecture for power plants and other similar complex capital-intensive large engineering systems.