bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural and Functional Basis of Red Palm Weevil: Pathogen Interactions Leading Towards Enhanced Crop Production in Date Palms
Authors: Alazmi Meshari , Alshammari N. , Alanazi Naimah A. , Sulieman Abdel Moneim E. 
Published: August 2021

Abstract
Food safety remains a significant challenge despite the growth and development in agricultural research and the advent of modern biotechnological and agricultural tools. Though the agriculturist struggles to aid the growing population's needs, many pathogen-based plant diseases by their direct impact on cell division and tissue development have led to the loss of tons of food crops every year. Though there are many conventional and traditional methods to overcome this issue, the amount and time spend are huge. Scientists have developed systems biology tools to study the root cause of the problem and rectify it. Host-pathogen protein interactions (HPIs) have a promising role in identifying the pathogens' strategy to conquer the host organism. In this paper, the interactions between the host Rhynchophorus ferrugineus (an invasive wood-boring pest that destroys palm) and the pathogens Proteus mirabilis, Serratia marcescens, and Klebsiella pneumoniae are comprehensively studied using protein-protein interactions, molecular docking, and followed by 200 ns molecular dynamics simulations. This study elucidates the structural and functional basis of these proteins leading towards better plant health, production, and reliability.
Academic Achievements in Children with ADHD in China: The Mediating Role of Executive Functions
Authors: DONG MIN , LIU LU , LI HAIMEI , WANG YUFENG , ZHOU XINLIN , QIAN QIUJIN 
Published: August 2021

Abstract
Background: Attention-deficit/hyperactivity disorder (ADHD) is often accompanied by lower academic achievements related to executive dysfunction, but the correlations remain unclear. The current study aimed to elucidate to what extent executive functions affect academic achievements in pediatric ADHD. Results:The results showed that mathematical achievements, reading comprehension achievements, subtraction and word semantics were all correlated with digit span and conversion. Reading comprehension achievements also had relationships with spatial span. In addition, reading comprehension achievements, subtraction and word semantics had negative relationships with the colour interference time and the semantic interference time. Furthermore, central executive function played significant meditating effects on mathematical achievements (dindirect effect=-0.04, P<0.05), subtraction (dindirect effect=-0.06, P=0.01) and word semantics (dindirect effect=-0.06, P<0.05). Inhibition played significant meditating effects on subtraction (dindirect effect=-0.03, P<0.05) and word semantics (dindirect effect=-0.06, P=0.01). Conversion had a significant mediating effect on word semantics (dindirect effect=-0.02, P=0.01). Conclusions:The findings suggested that central executive function, inhibition and conversion may have more important meditating effects on academic achievements of children with ADHD than other components of executive functions. Targeted executive function training should be used to effectively improve the targeted academic achievements of children with ADHD.
Biological Profile of Chronic Hepatitis B and its Predictive Factors According to Liver Histological Activity at the Renaissance Hospital, N’Djamena, Chad
Authors: Tahir Mahamat-Saleh , Ali Bolti Mahamat , Doffou Stanislas Adjeka , Assi Constant 
Published: August 2021

Abstract
Background: No study in black Africa has investigated the profile of chronic hepatitis B according to the new European association for the study of the liver (EASL) classification. The aim of the study was to determine the biological profile of chronic HBsAg carriers according to the EASL classification of chronic hepatitis B. Method: This is a prospective cross-sectional study carried out in the gastroenterology outpatient department at the Renaissance Hospital in N’Djamena from January, 2018 to July, 2019. All patients with chronic HBsAg were included and documented for at least one year. Patients with hepatitis C, hepatitis D or HIV or alcoholic were excluded. The biological profile was determined according the EASL classification: HBeAg-positive chronic infection, HBeAg-positive chronic hepatitis, HBeAg-negative chronic infection, HBeAg-negative chronic hepatitis and HBsAg-negative phase. Factors associated with presence of significant liver fibrosis were founded by logistical regression. Results: 106 patients were included. The average age were 42.4 years old. The sex ratio was 1.43. The median of the transaminase were 24 IU/ml (AST) and 21 IU/ml (ALT). 61 patients had HBeAg-negative chronic infection (59.8%) and 37 patients had HBeAg-negative chronic hepatitis (36.2%). HBeAg-positive chronic infection and HBeAg-positive chronic hepatitis were both seen in 2% of the cases. Significant liver fibrosis was independently associated with the ALT levels (Odds ratio=1.038 [1.009-1.068]; p=0.009). Conclusion: Chronic HBeAg-negative B infection is the main form in chronic HBsAg-positive carriers. Transaminases are a predictive factor for the presence of hepatic fibrosis.
Repetitive Elements in the Siberian Larch (Larix Sibirica Ledeb.) Nuclear Genome
Authors: Miroshnikova Kseniya A. , Akulova Vasilina S. , Biriukov Vladislav V. , Bondar Eugeniya I. , Kuzmin Dmitry A. , Oreshkova Natalya V. , Sadovsky Michael G. , Sharov Vadim V. , Krutovsky Konstantin V. 
Published: August 2021

Abstract
Background: Repetitive elements (REs) or repeats are sequences that occur multiple times in the genome. They represent a significant part of the gigantic conifer genomes (70-80%) relative to mammals and other plants and complicate whole genome sequencing and annotation. However, REs play important roles in evolution and adaptation processes in both plants and animals. Moreover, amino acid repeats play an important role in plant immunity being a structural element of the products of some disease resistance genes. Analysis of REs in conifer genomes is an important fundamental task.Results: REs were identified de novo and partly classified in the Siberian larch (Larix sibirica Ledeb.) nuclear genome for the first time. In total, 20.9 million REs were detected with the total size of 4.8 Gbp, which comprises about 39% of the 12.3 Gbp larch genome. Resistance genes with leucine-rich repeats (LRRs) were also identified and analyzed in the transcriptome data of autumn buds obtained using RNA-seq.Conclusions: For the first time, REs were identified and classified in the Siberian larch genome and transcriptome. In addition, LRRs and resistance genes were identified and analyzed in the Siberian larch transcriptomes from autumn buds. The larch genome contains twice as less RE compared to other conifers in the same Pinaceae family (39 vs 70-80%), and it might explain why it also has almost twice as smaller genome size (12 vs 18-31 Gbp).
An Exploratory Study Into Perceptions of the Impact COVID-19 Has Had on Sustainable Development Using Concept Mapping
Authors: Homer Stephen T. , Khor Kuan Siew 
Published: August 2021

Abstract
COVID-19 affected the pursuit of sustainable development in multifaceted ways. This study presents eight clusters of perceived impact of the pandemic and duration of respective impact that constantly developed ‘new normal’ to cope with unprecedented disruptions. The exploratory research applied the bottom-up approach where Concept System® Global MAX™ software facilitated online brainstorming to generate diverse opinions. Gen Z individuals were prompted with the following excerpt, ‘The COVID-19 pandemic has disrupted the world and led to unprecedented change. How do you believe this has impacted either positively or negatively, the global pursuit of sustainable development?’ Their opinions were analysed and reduced to generate unique statements for subsequent data collection, where participants sorting the items into thematic clusters before rating each of them. Subsequently, multidimensional scaling and cluster analysis is performed using Concept System® to propose eight-cluster solutions. In the pursuit of sustainability, this study suggested that the pandemic have contribute positive Impacts on environment and Development of ICT infrastructure, while highlighting negative and long-term Impacts on Economy and Impacts on Wellbeing on overall. This community-based participatory research provides explicit recommendation in prioritising response for managing the unprecedented effects of the pandemic.
Smart Resource Allocation Scheme for Mimo Microstrip Wireless Communication
Authors: kulkarni Sandeepkumar Kulkarni , Yanamshetti Raju 
Published: August 2021

Abstract
In this paper we have proposed a minimum noise shortest path determination scheme considering the amount of delay and energy consumed with respect to each path. An artificial neural network has been employed for classifying the minimum noise shortest path from the source to destination. A simulation work has been carried out with respect to different Signal-to-Noise (SNR) values in a thirty-node network with one Internet node and 100 bits of message length. Also, a comparison has been made between plain Dynamic Source Routing (DSR) and integrating the minimum noise shortest path algorithm with DSR. The simulation results show that with the increase of SNR, noise constraint in the path reduces, and data throughput increases.
Social Support and Depressive Symptoms: Exploring Stigma and Self-Efficacy in a Moderated Mediation Model
Authors: Wang Dong-Fang , Ma Yue-Jiao , Zhou Ya-Nan , Liu Yue-Heng , Hao Yu-Zhu , Zhang Jun-Hong , Liu Tie-Qiao 
Published: August 2021

Abstract
Background: Although some psychological processes, such as stigma and self-efficacy, affect the complicated relationship between social support and depressive symptoms, few studies explored a similar psychological mechanism among individuals with substance use disorders. Hence, this research investigates the mediating effects of stigma and the moderating effects of self-efficacy among the psychological mechanism that social support affects depressive symptoms. Methods: The study included 1040 Chinese participants with substance abuse disorders (SUDs) and completed a series of self-report questionnaires. R software was used to organize and clean up data sets and analyze mediation and moderation effects. Results: The result showed that stigma had a partial mediating effect on depressive symptoms, while self-efficacy moderated this relationship. More specifically, less social support increased depression symptoms by bringing about higher stigma. Besides, subjects with higher self-efficacy are less susceptible to stigma and therefore have mild depressive symptoms. Furthermore, clinical and theoretical implications are discussed in our study. Conclusions: Chinese SUDs patients’ depressive symptoms were indirectly affected by perceived social support via stigma and less affected by stigma with improved self-efficacy. The theoretical and practical implications of these results are discussed.
Inconsistency in Expression Pattern of a Five-lncRNA Signature As a Potential Diagnostic Biomarker for Gastric Cancer Patients in Bioinformatics and in Vitro
Authors: Ghanei Mahmoud , Poursheikhani Arash , Aarabi Azadeh , Taghehchian Negin , Abbaszadegan Mohammad Reza 
Published: August 2021

Abstract
BACKGROUND: Due to the diagnosis of gastric cancer in advance stages as well as its poor prognosis, finding biomarkers is essential.OBJECTIVE: In this study, using the TCGA RNAseq data of gastric cancer patients, we evaluated the diagnostic value of lncRNAs which had differential expression.METHODS: we evaluated P value, FDR, log fold change for whole transcripts. Next, by comparison of the RNAseq gene names with total known lncRNA names, we identified differntial expressed lncRNAs. Folowing, we calculated specificity and sensitivity for lncRNAs came from previous step. For more confirmation, we predict target genes and performed GO and KEGG signalling pathway analysis. At the end, we examined the reliability and consistency of expression of this signature in three gastric cancer cell lines and one of them in twenty tumoric and tumor adjacent normal tissue samples using qRT-PCR.RESULTS: Five lncRNAs had proper sensitivity and specificity and had target genes involved in cancer-related signaling pathways; however, they showed different expression pattern in TCGA data and in vitro.CONCLUSIONS: The results of our study demonstrated that the five-lncRNAs PART1, UCA1, DIRC3, HOTAIR, and HOXA11AS require more investigation to be confirmed as a diagnostic biomarker in gastric cancer.
Growth Responses of Avicennia germinans and Batis maritima Seedlings to Weathered Light Sweet Crude Oil Applied to Soil and Aboveground Tissues
Authors: Heintz William J. , Willis Jonathan 
Published: August 2021

Abstract
Oil spills are a significant stressor to coastal and maritime environments worldwide. The growth responses of Batis maritima and Avicennia germinans seedlings to weathered Deepwater Horizon oiling were assessed through a mesocosm study using a factorial arrangement of 4 soil oiling levels (0 L m-2, 1 L m-2, 2 L m-2, 4 L -m-2) x 3 tissue oiling levels (0% of stem height, 50% of stem height, 100% of stem height). Overall, growth metrics of B. maritima displayed much greater sensitivity to both tissue and soil oiling than A. germinans, which exhibited a relatively high tolerance to both routes of oiling exposure. Batis maritima in the 4 L m-2 soil oiling treatment demonstrated significant reductions in cumulative stem height and leaf number, whereas no significant effects of soil oiling on A. germinans were detected. This was reflected in end of the study biomass partitioning, where total aboveground and live aboveground biomass were significantly reduced for B. maritima with 4 L m-2 soil oiling, but no impacts to A. germinans were found. Tissue oiling of 100% did appear to initially reduce B. maritima stem diameter, but no effect of tissue oiling was discerned on biomass partitioning, suggesting that there were no impacts to integrated growth. These findings suggest that B. maritima would be more severely affected by heavy soil oiling than A. germinans.
Nonlinear Modeling and Experimental Characterization of Twin-Tube Hydraulic Adjustable Damper: Effects of Cavitation On Hysteretic Behavior
Authors: Zhang Qiang , Wang Xiaosun , Yang Yousheng 
Published: August 2021

Abstract
The hydraulic adjustable damper has attracted wide attention due to its superiorities of low energy consumption, fast response, strong durability, high reliability and simple structure. However, there has been no published detailed analysis about the effects of cavitation on the hysteresis of the hydraulic damper damping output. Furthermore, the existing damper models with simplified assumptions for the cavitation have not been completely studied. Therefore, a nonlinear model of twin-tube hydraulic adjustable dampers ( twin-tube HAD ) is proposed with an emphasis on the cavitation properties. Polytropic change in the gas content, seal friction, oil viscosity and the gas-oil emulsion flowing through orifices or valves are taken into consideration in the model. The cavitation form of twin-tube HAD valve is studied in depth and the dynamic cavitation number of hydraulic oil is formulated as a function of the gas volume fraction, then the damping force is characterized by the gas volume fraction. The model proposed in this paper can be used for accurately analytical investigation and it is useful in reducing damage from cavitation in similar nonlinear equipment. The mathematical model is validated by comparison against experimental results carried out on HONDA-EG8-RH twin-tube HAD in damper test facilities .
The Impact of Covid-19 On Maternal Delivery Experiences and Breastfeeding Practices in China: A Cross-Sectional Study
Authors: Yu Jinyue , Gao Mingyue , Wei Zhuang , Wells Jonathan CK , Fewtrell Mary 
Published: August 2021

Abstract
Background

The COVID-2019 pandemic has placed extensive pressure on health systems and posed a severe public health challenge worldwide. Lockdown measures implemented in many countries have delayed virus spread. However, a considerable number of people have faced unprecedented pressure, especially the pregnant and breast-feeding women, because face-to‐face professional support has been reduced during the lockdown in many countries.
Objectives

To compare the delivery and infant feeding experiences of women who delivered before (BL) versus during (DL) the Covid-19 pandemic in Beijing, China.
Methods

Women aged ≥ 18 years with an infant ≤ 18 months of age completed an anonymous survey. Information/links were shared online and via local clinics in Beijing. Logistic regression was performed to assess predictors of breastfeeding during the first 6-months.
Results

2233 women provided data; BL 1241 (55.6%), DL 992 (44.4%). The 6-month mostly breastfeeding (MBF, mainly breastfeeding with few non-formula fluids added) rate was significantly higher in the DL mothers (71.6%), compared to the BL mothers (60.6%). MBF was predicted by delivery during the lockdown period (OR1.42, 95% confidence interval 1.06, 1.90), younger maternal age, discussing infant feeding in a feeding support group, and getting support from friends or relatives. Moreover, relative to those little affected by COVID, those who were much affected were less likely to MBF.
Conclusion

The COVID-19 pandemic and lockdown measures influenced mothers’ planned birth location and breastfeeding intention. However, breastfeeding practice was maintained during the pandemic. The reported breastfeeding rates were high and our results highlight the importance of feeding support as well as potential beneficial effects of increased mother-infant contact during the lockdown period which is relevant even under normal circumstances.
Postmortem Diagnosis of Pulmonary Tumor Thrombotic Microangiopathy with Rapid Exacerbation in a Patient with Gastric Cancer: A Case Report
Authors: Kamidani Ryo , Kumada Keisuke , Okada Hideshi , Yoshimura Genki , Kanayama Tomohiro , Tomita Hiroyuki , Miura Tomotaka , Oiwa Hideaki , Mizuno Yosuke , Kitagawa Yuichiro , Yasuda Ryu , Fukuta Tetsuya , Miyake Takahito , Doi Tomoaki , Yoshida Takahiro , Yoshida Shozo , Hara Akira , Ogura Shinji 
Published: August 2021

Abstract
Background: Pulmonary tumor thrombotic microangiopathy (PTTM) is a condition that involves the development of pulmonary hypertension due to the presence of microscopic tumor emboli of the peripheral pulmonary arteries. Here, we report a case of rapidly exacerbating PTTM associated with gastric cancer that was identified postmortem through pathological autopsy.Case presentation: A 52-year-old Asian woman who experienced anterior chest pain while coughing visited the orthopedic department of the Gifu University Hospital. She was diagnosed as having multiple osteolytic bone metastases throughout her body and was subsequently scheduled to undergo combined positron emission tomography and computed tomography (CT) to search for a primary lesion. However, 4 days after her visit to the orthopedic department, she was unable to stand up and thus visited the emergency department. At the time of admission, physical examination results revealed that she had a percutaneous oxygen saturation level of 90% (on room air) and cyanosis, and that she was in a state of hemodynamic shock. Laboratory test results revealed elevated levels of fibrin degradation products and D-dimer in her blood. Chest CT results were normal. She was admitted to the hospital’s general ward for follow-up but soon entered a gradually worsening state of shock and respiratory failure. Electrocardiography revealed findings associated with right heart strain; however, contrast-enhanced CT did not reveal the presence of pulmonary embolism. She was admitted to the intensive care unit and was treated for pulmonary hypertension; however, 45 h after her arrival at the hospital, she died of respiratory failure. A pathological autopsy revealed the presence of gastric cancer, tumor microemboli, and fibrous intimal thickening of the peripheral arteries of both lungs; thus, a diagnosis of PTTM was made. Conclusions: In patients with carcinoma of unknown primary site and pulmonary hypertension with pulmonary embolism ruled out by CT, emergency physicians and intensivists must consider the possibility of PTTM, which represents an oncologic emergency, and initiate chemotherapy administration as soon as possible.
Safety Assessment of Oral 5-aminolevulinic Acid and Ferrous iron in Healthy Human Subjects: A Non-randomized, Open-label, Non-placebo-controlled Trial
Authors: Ito Hidenori , Tanaka Tohru 
Published: August 2021

Abstract
The combination of 5-aminolevulinic acid (5-ALA) phosphate and sodium ferrous citrate (SFC) has been approved as an ingredient of food supplement in several countries because of its wide applicability to healthcare areas. We aimed to assess the safety of 5-ALA phosphate and SFC in healthy adult subjects at the dose several times higher than that available on market. This was an open, non-randomized, non-placebo-controlled trial that included 11 men and 11 women. Doses of 250 mg 5-ALA phosphate and 143.4 mg SFC (15 mg as Fe) per day were orally administered for 28 days. Blood and urine analyses and interviews were conducted to assess the safety. No test compound-related adverse events or abnormal values were observed, except for elevated serum iron levels, which were mild to moderate and transient. Combined administration of 5-ALA phosphate and SFC to healthy adults is well-tolerated and safe at the dose and duration investigated in this study.
Heavy Thallium Based Fluoroperovskite TlAF3 (A = Ge, Sn and Pb) Compounds: A Computational Investigation
Authors: Zaman Shams U , Mehmood Nasir , Khan Sajid , Ahmad Rashid , Sultan Nadia , Ullah Farhat , Rahman Altaf Ur , Kim H. J. 
Published: August 2021

Abstract
Combination of heavy elements in forming a stable system leads to enhancement in effective atomic number making it desirable in many applications such as detection and shielding of radiation. We present our theoretical investigations on new Thallium based heavy fluoroperovskites TlAF3 (A = Ge, Sn and Pb). The study is carried out to explore the structural, elastic, electronic, and optical properties through the Density Functional Theory (DFT) using the Full-Potential Linearized Augmented Plane Wave (FP-LAPW) method implemented in WIEN2k. Generalized Gradient Approximation with consideration of electronic correlation effects (GGA+U) was employed for calculations. The lattice constants deduced from the optimization curves were found to be in the range of 4.00 Å to 4.85 Å. Elastic properties were obtained from the calculated elastic constants. From band structure calculations, it is evident that the bandgaps range from 0.84 to 1.89 eV. All the studied compounds exhibit indirect bandgap nature. Fluorine atom contributes significant number of electronic states in valence and conduction bands of all studied compounds. The optical response in terms of refractive index, extinction coefficient, optical conductivity, reflectivity, and absorption coefficients are calculated and discussed in the energy range of (0-20) eV. The properties of compounds in this study are being reported for the first time.