bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of incident atrial fibrillation with low-to-moderate alcohol consumption is associated with gender, region, alcohol category: a systematic review and meta-analysis
Authors: Yang Lingzhi , Chen Huaqiao , Shu Tingting , Pan Mingyong , Huang Wei 
Published: October 2021

Abstract

Aims
The association between low-to-moderate alcohol consumption and atrial fibrillation (AF) has yet to be fully elucidated. The main purpose of this meta-analysis was to estimate the risk of incident AF related to low-to-moderate alcohol consumption.

Methods and results
A meta-analysis was performed on 13 publications discussing the estimated risk for AF with habitual low-to-moderate alcohol intake in 10 266 315 participants. Graphical augmentations to the funnel plots were used to illustrate the potential impact of additional evidence on the current meta-analysis. Thirteen eligible studies were included in this meta-analysis. We found that moderate alcohol consumption was associated with an increased risk of incident AF in males [hazard ratio (HR) 1.09, 95% confidence interval (CI): 1.07–1.11, P &lt; 0.00001], Europeans (HR 1.32, 95% CI: 1.23–1.42, P &lt; 0.00001), and Asians (HR 1.09, 95% CI: 1.07–1.11, P &lt; 0.00001). Moderate beer consumption was associated with an increased risk of developing AF (HR 1.11, 95% CI: 1.02–1.21, P = 0.01). Low alcohol consumption conferred an increased risk of AF in males (HR 1.14, 95% CI: 1.01–1.28, P = 0.04) and Europeans (HR 1.12, 95% CI: 1.07–1.17, P &lt; 0.00001).

Conclusions
This analysis represents the increased risk of incident AF in males, Europeans, and Asians at moderate alcohol consumption levels and in males and Europeans at low alcohol consumption levels. Those who drink any preferred alcohol beverage at moderate levels should be cautious for incident AF. More studies are warranted to find those factors that influence alcohol’s effect on predisposing AF.
Weaving of bacterial cellulose by the Bcs secretion systems
Authors: Abidi Wiem , Torres-Sánchez Lucía , Siroy Axel , Krasteva Petya Violinova 
Published: October 2021

ABSTRACT
Cellulose is the most abundant biological compound on Earth and while it is the predominant building constituent of plants, it is also a key extracellular matrix component in many diverse bacterial species. While bacterial cellulose was first described in the 19th century, it was not until this last decade that a string of structural works provided insights into how the cellulose synthase BcsA, assisted by its inner-membrane partner BcsB, senses c-di-GMP to simultaneously polymerize its substrate and extrude the nascent polysaccharide across the inner bacterial membrane. It is now established that bacterial cellulose can be produced by several distinct types of cellulose secretion systems and that in addition to BcsAB, they can feature multiple accessory subunits, often indispensable for polysaccharide production. Importantly, the last years mark significant progress in our understanding not only of cellulose polymerization per se but also of the bigger picture of bacterial signaling, secretion system assembly, biofilm formation and host tissue colonization, as well as of structural and functional parallels of this dominant biosynthetic process between the bacterial and eukaryotic domains of life. Here, we review current mechanistic knowledge on bacterial cellulose secretion with focus on the structure, assembly and cooperativity of Bcs secretion system components.
Monitoring natural gas storage using Synthetic Aperture Radar: are the residuals informative?
Authors: Vasco D W , Samsonov Sergey V , Wang Kang , Burgmann Roland , Jeanne Pierre , Foxall William , Zhang Yingqi 
Published: October 2021

SUMMARY
Estimates of line-of-sight (LOS) displacements from Interferometric Synthetic Aperture Radar (InSAR) observations serve as the basis of the long-term monitoring of an operating natural gas storage site at Honor Rancho in California. An inversion algorithm is used to estimate the portion of the signal that is attributable to deformation within the gas storage reservoir, located at a depth of around 3 km. Removing this contribution produces residuals that are used to characterize the background variation is surface deformation at the gas storage facility and to determine a threshold that can signify unusually large residuals. An application to almost 7 yr of InSAR data, from 2011 until 2018, indicates that there are intervals of heightened residuals as well as brief episodes of anomalously large misfits. An examination of the spatial distributions of the individual residual LOS displacements indicates larger displacements in an alluvial valley just south of the reservoir, with rapid spatial variations in sign, indicating a rather shallow origin. Furthermore, the two anomalous events also involve rapid spatial variations in the LOS displacement residuals directly above the storage facility. The results demonstrate that the technique of extracting residuals after removing the reservoir signal is a useful approach, even in the case of this deep reservoir, and is a promising method for long-term monitoring.
The focal mechanism of the 7 September 1920,Mw 6.5 earthquake: insights into the seismotectonics of the Lunigiana–Garfagnana area, Tuscany, Italy
Authors: Eva Elena , Pettenati Franco , Solarino Stefano , Sirovich Livio 
Published: October 2021

SUMMARYTo understand the seismotectonics and the seismic hazard of the study sector of the Northern Apennines (Italy), one of the most important earthquakes of magnitude Mw = 6.5 which struck the Lunigiana and Garfagnana areas (Tuscany) on 7 September 1920 should be studied. Given the early instrumental epoch of the event, neither geometric and kinematic information on the fault-source nor its fault-plane solution were available. Both areas were candidates for hosting the source fault and there was uncertainty between a normal fault with Apenninic direction or an anti-Apenninic strike-slip. We retrieved 11 focal parameters (including the fault-plane solution) of the 1920 earthquake. Only macroseismic intensity information (from 499 inhabited centres) through the KF-NGA inversion technique was used. This technique uses a Kinematic model of the earthquake source and speeds up the calculation by a Genetic Algorithm with Niching.The result is a pure dip-slip focal solution. The intrinsic ambiguities of the KF-NGA method (±180° on the rake angle; choice of the fault plane between the two nodal planes) were solved with field and seismotectonic evidence. The earthquake was generated by a normal fault (rake angle = 265° ± 8°) with an Apennine direction (114° ± 5°) and dipping 38° ± 6° towards SW. The likely candidate for hosting the source-fault in 1920 is the Compione-Comano fault that borders the NE edge of the Lunigiana graben.The KF-NGA algorithm proved to be invaluable for studying the kinematics of early instrumental earthquakes and allowed us to uniquely individuate, for the first time ever, the seismogenic source of the 1920 earthquake. Our findings have implications in hazard computation and seismotectonic contexts.
Transdimensional Bayesian inversion of magnetotelluric data in anisotropic layered media with galvanic distortion correction
Authors: Peng Ronghua , Han Bo , Hu Xiangyun , Li Jianhui , Liu Yajun 
Published: October 2021

SUMMARYPresence of electrical anisotropy in the lithosphere can provide useful constraints on regional structure patterns and dynamics of tectonic processes, and they can be imaged by magnetotelluric (MT) data. However, Inversion of MT data for anisotropic structures using standard gradient-based approaches requires subjective choices of model regularization for constraining structure and anisotropy complexity. Furthermore, the ubiquitous presence of galvanic distortion due to small-scale near-surface conductivity inhomogeneities prevents accurate imaging of subsurface structures if ignored or not properly removed. Here, we present a transdimensional Bayesian approach for inverting MT data in layered anisotropic media. The algorithm allows flexible model parametrization, in which both the number of layers and model parameters of each layer are treated as unknowns. In this manner, the presence or absence of anisotropy within the layers, as well as the level of model complexity, is determined adaptively by the data. In addition, to account for the effects of galvanic distortion, three frequency-independent distortion parameters resulting from the distortion decomposition are treated as additional variables during the inversion. We demonstrate the efficiency of the algorithm to resolve both isotropic and anisotropic structures with synthetic and field MT data sets affected by galvanic distortion effects. The transdimensional inversion results for the field data are compatible with results from previous studies, and our results improve the constraints on the magnitude and the azimuth (i.e. most conductive direction) of electrically anisotropic structures. For practical applications, the validity of 1-D anisotropic approximation should be first tested prior to the use of our approach. Otherwise it may produce spurious anisotropic structures due to the inapplicability of the anisotropic 1-D inversion for MT data affected by 2-D or 3-D electrical resistivity structures.
Nonfiction Theater
Authors: Feagin Susan L 
Published: October 2021

Abstract
Are there nonfiction genres of theater scripts, just as there are nonfiction genres of film, such as documentary, and of literature, such as biography and history? I propose that there are, and that Verbatim Theater qualifies as a nonfiction theater genre. What sets it apart is that it is supposed to instruct performers not merely to reenact, or represent, a series of events, but overall to present evidence or arguments for a thesis, or for the audience to draw their own conclusions. For scripts to present evidence, audiences have to be able to filter out what is supposed to serve as evidence from what else occurs on stage. Unlike various other genres of theater that one might initially appear to be nonfiction—such as autobiographical dialogues, Documentary Theater, and ethnodrama—Verbatim Theater does this.
Greenness Assessment of Two Validated Stability-Indicating Chromatographic Methods for Estimating Modafinil Using the Analytical Eco-Scale
Authors: Elsheikh Soha G , Hassan Abeer M E , Fayez Yasmin M , El-Mosallamy Sally S 
Published: October 2021

Abstract

Background
Modafinil (MDF) is one of the drugs used for the treatment of narcolepsy.

Objective
This manuscript describes the development and validation of two chromatographic stability-indicating methods for MDF in the presence of its acid-induced degradation product.

Methods
MDF was degraded under different stress conditions and identification of the degradation product was performed using IR and mass spectroscopy. The first method involved TLC, in which plates precoated with silica gel G60 F254 were used and the developing system was dichloromethane– methanol (9:1, v/v). The second method was an eco-friendly (HPLC) method that utilized a C-18 column and ethanol–H2O (30:70, v/v) as a mobile phase with a flow rate of 1 mL/min and UV detection at 220 nm.

Results
Good linear relationships were obtained within the ranges 1–10 µg/band and 2–10 µg/mL for TLC–densitometry and HPLC, respectively. The obtained results were statistically compared with those of the official HPLC method and showed no significant difference with respect to their accuracy and precision at P = 0.05. Greenness scores represent excellent green analysis results in comparison with the reported studies.

Conclusions
The proposed methods were validated according to ICH guidelines and were applied on bulk powder and pharmaceutical dosage forms using eco-friendly mobile phases in line with worldwide trends.

Highlights
Chromatographic methods have been validated for the estimation of MDF in the presence of its degradation product. Clarification of the degradation pathway and elucidation of the structure were stated for the first time. This is the first published method using greenness assessment metrics for the analysis of MDF.
Comparison of Volatile Oils and Primary Metabolites of Raw and Honey-Processed Ephedrae Herba by GC–MS and Chemometrics
Authors: Guo Mei , Wu Zhicong , An Qi , Li Hengyang , Wang Lei , Zheng Yuguang , Guo Long , Zhang Dan 
Published: October 2021

Abstract

Background
Ephedrae Herba (EH) is the terrestrial stem of Ephedra sinica Stapf, E. intermedia Schrenk et C. A. Mey., or E. equisetina Bge, which has been used as a diaphoretic, antiasthmatic, and diuretic. Honey-processed EH (HEH) is a widely used traditional Chinese medicine, and has a better effect of dispersing lung qi and relieving asthma and a lower effect of dispelling cold than raw EH (REH).

Objective
To understand the differences in volatile oils and primary metabolites between REH and honey-processed HEH, and to provide a reference for elucidating the mechanism behind the effect of this processing.

Methods
A system data acquisition and mining strategy was designed to investigate the differences in volatiles and primary metabolites between the REH and HEH, based on GC–MS coupled with multivariate statistical analysis, including principal component analysis and orthogonal partial least squares discriminant analysis.

Results
Overall, 15 volatile oils and 14 primary metabolites were shown to be potential characteristic markers differentiating REH and HEH.

Conclusion
The results may provide a scientific foundation for comprehensively revealing the honey-processing mechanism of EH.

Highlight
Volatile oils and primary metabolites were used to distinguish REH and HEH and elucidate the processing mechanism of EH for the first time.
3 Infant-directed Vocal Communication in Sheep
Authors: Wang Yongjie , McClanahan Kylie , Ma Weiyi , Li Qinghua , Huang Yan 
Published: October 2021

Abstract
Infant-directed speech (IDS) in humans, AKA motherese, is different from normal speech with a higher pitch, higher frequency range, slower pace, and more repetition. infants usually are believed to react differently to IDS compared to adult-directed speech. Studies showed that IDS facilitates infant’s speech segmentation, word memory, word learning, and communicative development. IDS is common across languages and cultures, but the evolutionary origin of IDS is a myth. The objective of this study is to find out whether the special style of vocalization namely infant-directed vocalization (IDV), which differs from adult-directed vocalization (ADV), can be also observed in non-human, even non-primate species. The ADV and IDV of ewes were recorded. The sound wave features of the recordings were analyzed by visualization and machine learning. The ADV had representative peak frequencies at 175, 720, and 860Hz, while IDV only had one peak characteristic frequency at 245Hz. The machine-learning algorithm was able to clearly identify (overall accuracy was 89.3%) the distinguishing characteristics between ADV and IDV. Then we tested if the lamb reacts differently to the ewe’s IDV and ADV. The recording was played when the pre-weaning lambs were individually kept and the behavior of the lambs was recorded. The results showed that the lambs looked towards the sound source when IDV was played more than ADV (6.1 vs 3.1 times/5 min); they moved towards the sound source of IDV 8.6 times per 5 min compared to ADV which was 2.8 times/5min), and they bleated back to the sound source when IDV was played (18.0 times/5 min) more than when ADV was played (11.3 time/5 min); within 2 min after the recording played, lambs bleated back to IDV 8 times compared to ADV 4.8 times. This indicated the ewes’ IDV and ADV show different socio-emotional and attention effects on their lambs.
9 The Effects of Feeding Cannabidiol Oil on Behavior of Stalled Horses
Authors: Turner Paxton L , Guay Kimberly A , Jones Trinette , Cohen Lori , Elwonger Faith , Van Geem Renata , Smith William B 
Published: October 2021

Abstract
Using cannabidiol (CBD) in animals has increased since the 2018 Agricultural Improvement Act was passed. Previous work in laboratory animals suggests supplementation with CBD reduced anxiety, compulsive behaviors, and brain activity of limbic and paralimbic areas. Horses exhibit anxiety due to training or housing situations, which is sometimes expressed via stereotypic behaviors including cribbing, aggression, etc. These behaviors can indicate underlying stressors and sometimes causes impairment; therefore, supplementing CBD may reduce undesirable behaviors in horses, consequently improving the health and overall welfare. The study objective was to determine if a single oral dose of CBD would result in adverse effects in horses. Four mature mares and four mature geldings were used in a randomized-control treatment design. Horses typically housed in paddocks, but not novel to stalling were housed in 11’ X 14’ stalls with cameras to record behavior, feed, and water intake. Horses were acclimated to feeding methods and stall environment for one week. Behavior was recorded for 24hr after a dosage of olive oil was administered as a control (CON). Horses were returned to their paddock for one week, then randomly assigned to either a LOW (0.3mg/kg BW; n = 4) or HIGH (0.6 mg/kg BW; n = 4) treatment of CBD oil. After oral dosing, horses were stalled for observation. Stereotypic behaviors such as pawing, cribbing, and aggression were quantified using the Observer XTTM program. Observations were analyzed in R Studio© for analysis of variance (ANOVA). The occurrence of stereotypic behaviors was lower (P = 0.03) in horses given oral CBD. Actions occurred more frequently during feeding sessions, behaviors including aggression and pawing occurred less when horses were given the High dose compared to Control (113 to 26 and 69 to 27) respectively. Based on results, oral administration of the particular cannabidiol product used in this study may mediate negative behaviors in stalled horses.
29 Effects of Recent and Ancient Inbreeding on Growth in American Angus Cattle
Authors: Lozada-Soto Emmanuel A , Tiezzi Francesco , Lu Duc , Miller Stephen P , Cole John B , Maltecca Christian 
Published: October 2021

Abstract
The accumulation of inbreeding can lead to an unfavorable change in the phenotypic value of individuals for traits related to fitness, also known as inbreeding depression. However, inbreeding accumulated at a more distant past (ancient inbreeding) is expected to have a smaller depressive effect than that accumulated more recently due to the loss of detrimental alleles caused by purifying selection. Therefore, the aim of this study was to quantify the inbreeding depression caused by recent and ancient inbreeding for birth weight, weaning weight, and post-weaning gain. Pedigree and genomic information were obtained from Angus Genetics, Inc. (St. Joseph, MO) for 569,364 individuals from the American Angus breed. Pedigree inbreeding and genomic inbreeding based on runs of homozygosity (ROH) were estimated using the SNP1101 software. Model-based genomic inbreeding based on the probability a marker is part of a homozygous-by-descent segment (HBD) was estimated using the RZooROH in R. The generational cutoffs for designating inbreeding as recent was that acquired 5 generations ago or sooner for pedigree, 6.25 generations ago or sooner for ROH, and 8 generations ago or sooner for HBD inbreeding. The effect of a 1% increase in inbreeding was modeled in males and females using a linear mixed model approach. Recent pedigree inbreeding was found to decrease birth weight by 0.04 and 0.03 kg, decrease weaning weight by 0.50 and 0.48 kg, and decrease post-weaning gain by 0.62 and 0.32 kg, in males and females respectively. Ancient pedigree inbreeding was generally found to have no effect on growth. For genomic inbreeding, when both recent and ancient inbreeding had a detrimental effect on growth, recent inbreeding generally had a larger effect. The results of this study demonstrate that inbreeding accumulated recently should be quantified and managed in beef cattle populations to avoid economic losses.
31 Gametic Incompatibility: Improving the Success of Mate Allocation in Dairy Cattle
Authors: Martin Audrey A A , Id-Lahoucine Samir , Tulpan Dan , Leblanc Stephen J , Cánovas Angela , Baes Christine F , Schenkel Flavio S 
Published: October 2021

Abstract
In the dairy industry, mate allocation is mainly based on the parents’ breeding values and inbreeding coefficients aiming to achieve the producer’s breeding goal. With artificial insemination, the portfolio of sires to choose from is large and the quality of the semen doses is standardized. However, not all sire-dam matings are equally likely to produce a successful pregnancy. Among other reproduction issues, the success of a mating could vary due to the incompatibility of gametes coming from the sire and the dam and could influence the fertilization’s success, additionally to the reproductive capacity of the parents. Considering the gametic incompatibility of the potential parents could be a novel option to improve mating plans. Under the hypothesis that gametic incompatibility has a significant effect on reproduction and reduces the odds of fertilization and pregnancy, this study aimed to determine the genetic background of gametic incompatibility. Transmission ratio distortion (TRD), which detects deviations from Mendelian inheritance expectations, is commonly used to identify deleterious mutations. We adapted the TRD model by including an interaction effect between the gametes leading to the offspring genotype to detect regions with TRD effects and gametic incompatibility. Our dataset contained 436,651 genotyped (50K SNP) Canadian Holstein cattle from 283,817 parents-offspring trios. A total of 482 regions with TRD containing 671 positional genes were found. The functional analysis detected biological pathways associated with uterus development, embryonic skeletal system development, and nervous system development. Additionally, gene ontology terms from the topology-based pathway enrichment analysis were mostly related to the steroid hormones signalling pathway. Although difficult, genes specific to gametic incompatibility could be differentiated from genes underlying other reproduction processes by refining the genetic regions with TRD. With further investigation, we will provide new information to improve mate allocation for the dairy cattle industry.