bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiscale Computational Model Predicts Mouse Skin Kinematics Under Tensile Loading
Authors: Witt Nathan J. , Woessner Alan E. , Quinn Kyle P. , Sander Edward A. 
Published: November 2021

Abstract
Skin is a complex tissue whose biomechanical properties are generally understood in terms of an incompressible material whose microstructure undergoes affine deformations. A growing number of experiments, however, have demonstrated that skin has a high Poisson's ratio, substantially decreases in volume during uniaxial tensile loading, and demonstrates collagen fiber kinematics that are not affine with local deformation. In order to better understand the mechanical basis for these properties, we constructed multiscale mechanical models (MSM) of mouse skin based on microstructural multiphoton microscopy imaging of the dermal microstructure acquired during mechanical testing. Three models that spanned the cases of highly aligned, moderately aligned, and nearly random fiber networks were examined and compared to the data acquired from uniaxially stretched skin. Our results demonstrate that MSMs consisting of networks of matched fiber organization can predict the biomechanical behavior of mouse skin, including the large decrease in tissue volume and nonaffine fiber kinematics observed under uniaxial tension.
Analytical Multi-Parametric Design Optimization for the Miniaturization of Flip-Chip Package
Authors: Ng Fei Chong , Abas Mohamad Aizat 
Published: November 2021

Abstract
Recent advances in the micro-electronics industry have increased the demand for smaller and more compact package devices with higher performance. This paper presents an analytical multiparametric design optimization approach for the miniaturization of flip-chip package, while considering the filling time of the subsequent underfill encapsulation process. The design optimization approach was based on the latest regional segregation-based analytical filling time model. Numerical simulation was conducted to verify the governed analytical model. The discrepancies in the filling times are less than 9.9%, and the predicted critical bump pitch has a low deviation of 4.1%, affirming that both the analytical and numerical models were in great consensus. The variation effects of bump pitch, gap height, and contact angle on the filling time were analyzed and discussed thoroughly. Both the critical bump pitch and the critical gap height were computed and fitted into respective empirical equations. Subsequently, a new multiparametric design optimization approach based on the thresholding and criticality of underfill parameters was proposed to determine the optimum parameters that yield to the most compact flip-chip package with acceptable low filling time during the encapsulation process. Lastly, this proposed optimization technique was tested on the four flip-chips used in a previously published underfill experiment.
Using Simulation-Based Active Learning Strategies for Teaching Biofluids Concepts
Authors: Mukherjee Debanjan , Barker Alex J. 
Published: November 2021

AbstractBiofluids comprises a core topical domain for modern biomedical engineering education. Like other biomedical topic areas, biofluids education must address highly interdisciplinary and applied topics. Concept/problem-based active learning approaches can provide effective avenues to teach such diverse and applied topics. However, with the heterogeneity within biofluids topics across cellular, physiological, and/or extra-organismal scales, it is important to develop active learning content that enables students to explore concepts with appropriate context. This challenge is further complicated by the need to administer such content remotely (due to the Covid-19 pandemic). Here, we outline our design process and implementation experience for simulation-based active learning modules for a newly developed physiological biofluids course. We share the overall design approach, with two example cases of simulation-based concept exploration: (a) arterial Windkessel effects and lumped parameter hemodynamic analysis; and (b) curvature-induced helical flow in human aorta illustrated using four-dimensional (4D) flow magnetic resonance imaging (MRI). Evidence from student survey ratings, student comments and feedback, and monitoring student performance for course deliverables indicate positive student response toward these modules, and efficacy of the modules in enabling student learning. Based on our design and implementation experience, we argue that simulation-based approaches can enable active learning of biofluids through remote and online learning modalities.
Cre/CysC ratio may predict muscle composition and is associated with glucose disposal ability and macrovascular disease in patients with type 2 diabetes
Authors: Yang Qing , Zhang Mei , Sun Peng , Li Yanying , Xu Huichao , Wang Kejun , Shen Hongshan , Ban Bo , Liu Fupeng 
Published: November 2021

IntroductionSince the ratio of creatinine to cystatin C (Cre/CysC) can reflect muscle volume, it has been proven to be a predictor of sarcopenia in patients with or without diabetes. Here, we investigated the predictive value of Cre/CysC for the skeletal muscle composition and its correlations with glucose disposal ability and diabetic complications in patients with type 2 diabetes.Research design and methodsThe skeletal muscle index (SMI) and mean skeletal muscle attenuation (MMA) values of 193 patients with type 2 diabetes were obtained through analyses of CT images at the lumbar 3 level.ResultsSerum Cre/CysC was significantly correlated with both the SMI (r=0.375, p<0.001) and MMA (r=0.378, p<0.001). Multiple stepwise linear regression analysis demonstrated that Cre/CysC was the only biochemical predictor of the SMI (β=0.48 (95% CI 0.02 to 0.94)) and MMA (β=0.57 (95% CI 0.14 to 1.01)). Furthermore, the fat mass index (FMI) was significantly associated with the MMA (r=−0.481, p<0.001) but not the SMI (r=0.101, p=0.164). In the diabetic complications analysis, Cre/CysC was significantly lower in patients with cardiovascular disease (95% CI (−1.47 to –0.22), p=0.008) and lower extremity arterial disease (95% CI (−1.44 to –0.29), p=0.004). Moreover, in the 100 g steamed bun test, Cre/CysC was significantly correlated with glucose levels at 60 min (r=−0.162, p=0.045), 120 min (r=−0.287, p<0.001) and 180 min (r=−0.313, p<0.001).ConclusionsCre/CysC may be a valuable predictor of skeletal muscle composition in type 2 diabetes. Patients with a higher Cre/CysC may have a better ability to dispose of postprandial glucose and are at a lower risk of macrovascular disease.
Effect of milk supplementation on the status of micronutrients among rural school children aged 5–19 years in a tribal predominating district of India
Authors: Kumar Chandramani , Rana Rishabh Kumar , Kumar Mithilesh , Kujur Anit , Kashyap Vivek , Singh Shashi Bhushan , Sagar Vidya , Kumari Neelanjali , Kumar Dewesh 
Published: November 2021

BackgroundIn the tribal state of Jharkhand, there have been very few studies on micronutrient deficiency and how it is addressed among school children. This study was conceived and undertaken to assess the effect of milk supplementation on the micronutrient status of school children.DesignA comparative observational study was conducted among school children of a tribal district in India during 2017–2018. Two groups of schools/clusters were randomly selected, one with milk supplementation and the other without supplementation. A total of 318 children from the two groups of schools were recruited for biochemical analysis of certain micronutrients, such as calcium, vitamin D, vitamin B12and iron (haemoglobin level), using cluster random sampling. Data were analysed using SPSS V.20.0 software, and multiple logistic regression analysis was done to determine the predictors of serum calcium and vitamin B12level among school children.ResultsAlmost all children from both groups had vitamin D deficiency. A higher risk of lower serum vitamin B12level (OR 2.59, 95% CI 1.61 to 4.16) and calcium level (OR 3.36, 95% CI 1.74 to 6.49) was observed in children of the control group. The difference in the proportion of anaemia in the two study groups was found to be statistically insignificant. Milk consumption was found to be the only significant predictor of normal vitamin B12and calcium level in the present study.ConclusionsIn this study, it was concluded that milk consumption may help in improving the calcium and vitamin B12status of school children of a tribal state, whereas it does not have any significant effect on vitamin D level.
Evaluating the impact of a national strategic leader development programme for UK doctors: myth-busting, mind-changing, mood-enhancing
Authors: McKimm Judy , Lees Peter , Armit Kirsten , Mills Chloe 
Published: November 2021

BackgroundThe drive towards engaging UK doctors in clinical leadership and management has involved many initiatives at various levels.MethodsThis paper reports on the findings of an in-depth evaluation of a national medical leadership programme for doctors in the late stages of specialty or general practitioner (GP) training or have just become consultants or GPs.ResultsThe evaluation clearly demonstrates the impact of this programme and the benefits for the individuals and organisations involved, particularly around stimulating a shift in mood and a major mindset shift in what medical leadership is (and is not) and what they can achieve as medical leaders. The programme structure and activities allowed participants to learn from a range of senior decision-makers about policy and strategic developments and processes. However, the evaluation also highlighted that some pervasive myths still exist around medical leadership and management which, if not addressed, will hamper efforts to fully engage doctors in taking on strategic leadership roles.ConclusionClinical leadership programmes are valuable, but must be carefully managed to extract the full value from them.
Retrospective analysis of marine growth and relationships to return rates of Penobscot River Atlantic salmon
Authors: Barajas Miguel F. , Sheehan Timothy F. , Haas-Castro Ruth E. , Ellingson Brandon , Mills Katherine E. 
Published: November 2021

Beginning in the 1980s, return rates of Atlantic salmon (Salmo salar) to the Penobscot River, Maine, USA, declined and have persisted at low levels. This downturn coincided with similar declines in North American and European Atlantic salmon stocks and with changes in the Northwest Atlantic ecosystem. Previous studies investigated whether early marine growth explained the declines, but results varied, with decreased growth associated with declines in European stocks but not North American stocks. In this study, we evaluate whether growth over the entire marine stage is related to Atlantic salmon marine survival. We constructed a growth time series from scales of returned Penobscot River Atlantic salmon spanning periods of varying marine survival. We used analysis of variance (ANOVA) and post hoc tests to quantify seasonal growth increment differences and principal component analysis to characterize variability among the suite of growth increments. We observed reduced growth during the second winter and second marine year starting in the 1990s, with compensatory seasonal growth relationships. These results indicate that diminished growth during late marine stages is associated with low return rates in this population.
Model compression and simplification pipelines for fast deep neural network inference in FPGAs in HEP
Authors: Francescato Simone , Giagu Stefano , Riti Federica , Russo Graziella , Sabetta Luigi , Tortonesi Federico 
Published: November 2021

AbstractResource utilization plays a crucial role for successful implementation of fast real-time inference for deep neural networks (DNNs) and convolutional neural networks (CNNs) on latest generation of hardware accelerators (FPGAs, SoCs, ACAPs, GPUs). To fulfil the needs of the triggers that are in development for the upgraded LHC detectors, we have developed a multi-stage compression approach based on conventional compression strategies (pruning and quantization) to reduce the memory footprint of the model and knowledge transfer techniques, crucial to streamline the DNNs simplifying the synthesis phase in the FPGA firmware and improving explainability. We present the developed methodologies and the results of the implementation in a working engineering pipeline used as pre-processing stage to high level synthesis tools (HLS4ML, Xilinx Vivado HLS, etc.). We show how it is possible to build ultra-light deep neural networks in practice, by applying the method to a realistic HEP use-case: a toy simulation of one of the triggers planned for the HL-LHC.
Coronary Endothelium‐Dependent Vasomotor Function After Drug‐Eluting Stent and Bioresorbable Scaffold Implantation
Authors: Gomez‐Lara Josep , Oyarzabal Loreto , Ortega‐Paz Luis , Brugaletta Salvatore , Romaguera Rafael , Salvatella Neus , Roura Gerard , Rivero Fernando , Fuentes Lara , Alfonso Fernando , Otaegui Imanol , Vandeloo Bert , Vaquerizo Beatriz , Sabate Manel , Comin‐Colet Josep , Gomez‐Hospital Joan‐Antoni 
Published: November 2021

Background
Early generation drug‐eluting stents (DESs) showed a high grade of coronary endothelial dysfunction that was attributed to lack of stent reendothelialization. Endothelium‐dependent vasomotor response of current DESs and bioresorbable scaffolds (BRSs) remains unknown. This study sought to assess the device‐related endothelial function of current devices and to correlate neointima healing with endothelial function.

Methods and Results

A total of 206 patients from 4 randomized trials treated with the durable‐polymer everolimus‐eluting Xience (n=44), bioresorbable‐polymer sirolimus‐eluting Orsiro (n=35), polymer‐free biolimus‐eluting Biofreedom (n=24), bioactive endothelial‐progenitor cell‐capturing sirolimus‐eluting Combo DES (n=25), polymer‐based everolimus‐eluting Absorb (n=44), and Mg‐based sirolimus‐eluting Magmaris BRS (n=34) underwent endothelium‐dependent vasomotor tests and optical coherence tomography imaging, as per protocol, at follow‐up. Crude vasomotor responses of distal segments to low‐dose acetylcholine (10
−6
mol/L) were different between groups: bioresorbablepolymer DEShad the worst (−8.4%±12.6%) and durable‐polymer DES had the most physiologic (−0.4%±11.8%;
P
=0.014). High‐dose acetylcholine (10
−4
mol/L) showed similar responses between groups (ranging from −10.8%±11.6% to −18.1%±15.4%;
P
=0.229). Device healing was different between devices. Uncovered struts ranged from 6.3%±7.1% (bioresorbable‐polymer DES) to 2.5%±4.5% (bioactive DES;
P
=0.056). In multivariate models, endothelium‐dependent vasomotor response was associated with age, bioresorbable‐polymer DES, and angiographic lumen loss, but not with strut coverage nor plaque type. Endothelial dysfunction (defined as ≥4% vasoconstriction) was observed in 46.6% of patients with low‐dose and 68.9% with high‐dose acetylcholine, without differences between groups.

Conclusions
At follow‐up, endothelial dysfunction was frequently observed in distal segments treated with current stents without remarkable differences between devices. Although neointima healing was different between devices, poor healing was not associated with endothelial dysfunction.
Incidence of Infective Endocarditis Among Patients With Tetralogy of Fallot
Authors: Havers‐Borgersen Eva , Butt Jawad H. , Smerup Morten , Gislason Gunnar H. , Torp‐Pedersen Christian , Gröning Mathis , Schmidt Michael Rahbek , Søndergaard Lars , Køber Lars , Fosbøl Emil L. 
Published: November 2021

Background
Patients with tetralogy of Fallot (ToF) are considered at high risk of infective endocarditis (IE) as a result of altered hemodynamics and multiple invasive procedures, including pulmonary valve replacement (PVR). Data on the long‐term risk of IE are sparse.

Methods and Results
In this observational cohort study, all patients with ToF born from 1977 to 2018 were identified using Danish nationwide registries and followed from date of birth until occurrence of first‐time IE, emigration, death, or end of study (December 31, 2018). The comparative risk of IE among patients with ToF versus age‐ and sex‐matched controls from the background population was assessed. Because of rules on anonymity, exact numbers cannot be reported if the number of patients is <4. A total of 1164 patients with ToF were identified and matched with 4656 controls. Among patients with ToF, 851 (73.1%) underwent early surgical intracardiac repair and 276 (23.7%) underwent PVR during follow‐up. During a median follow‐up of 20.3 years, 41 (3.5%) patients with ToF (comprising 24 [8.7%] with PVR and 17 [1.9%] without PVR) and <4 (<0.8%) controls were admitted with IE. The incidence rates of IE per 10 000 person‐years were 22.4 (95% CI, 16.5–30.4) and 0.1 (95% CI, 0.01–0.7) among patients and controls, respectively. Moreover, PVR was associated with a further increased incidence of IE among patients with ToF (incidence rates per 10 000 person‐years with and without PVR were 46.7 [95% CI, 25.1–86.6] and 2.8 [95% CI 2.0–4.0], respectively).

Conclusions
Patients with ToF are associated with a substantially higher incidence of IE than the background population. In particular, PVR was associated with an increased incidence of IE. With an increasing life expectancy of these patients, intensified awareness, preventive measures, and surveillance of this patient group are decisive.
Lack of Association Between Neurohormonal Blockade and Survival in Transthyretin Cardiac Amyloidosis
Authors: Cheng Richard K. , Vasbinder Alexi , Levy Wayne C. , Goyal Parag , Griffin Jan M. , Leedy Douglas J. , Maurer Mathew S. 
Published: November 2021

Background
Despite the belief that heart failure therapies are not effective in transthyretin cardiac amyloidosis, data are limited. We tested the association of neurohormonal blockade use with survival.

Methods and Results
A total of 309 consecutive patients with transthyretin cardiac amyloidosis were identified. Medication inventory was obtained at baseline and subsequent visits. Exposure included a neurohormonal blockade class (β‐blocker [βB], angiotensin‐converting enzyme inhibitor/angiotensin receptor blocker, and mineralocorticoid antagonist) at baseline and subsequent visits. βB was modeled as baseline use, time‐varying use, and in an inverse probability treatment weighted model. Primary outcome was all‐cause mortality analyzed with adjusted Cox proportional hazards models. Continuing compared with stopping βB during follow‐up was tested. Mean age was 73.2 years, 84.1% were men, and 17.2% had atrial fibrillation/flutter at baseline. At the time of study entry, 49.8% were on βBs, 35.0% were on angiotensin‐converting enzyme inhibitors/angiotensin receptor blockers, and 23.9% were on mineralocorticoid antagonists. For the total cohort, there was a trend toward harm in the unadjusted model for baseline βB use, but this was neutral after adjustment. When βB use was analyzed as a time‐varying exposure, there was no association with mortality. βB discontinuation was associated with decreased mortality for the total cohort. Findings were consistent in inverse probability treatment weighted models. For angiotensin‐converting enzyme inhibitor/angiotensin receptor blocker or mineralocorticoid antagonist use, there was no association with mortality after adjustment for the total cohort.

Conclusions
There was no association of neurohormonal blockade use with survival in transthyretin cardiac amyloidosis. For the total cohort, deprescribing βB may be associated with improved survival. Additional studies are needed to confirm these findings.
Serving the Underserved: Microcredit as a Pathway to Commercial Banks
Authors: Agarwal Sumit , Kigabo Thomas , Minoiu Camelia , Presbitero Andrea F. , Silva André F. 
Published: November 2021

AbstractA large-scale microcredit expansion program—together with a credit bureau accessible to all lenders—can enable unbanked borrowers to build a credit history, facilitating their transition to commercial banks. Loan-level data from Rwanda show the program improved access to credit and reduced poverty. A sizable share of first-time borrowers switched to commercial banks, which cream-skim less risky borrowers and grant them larger, cheaper, and longer-maturity loans. Switchers have lower default risk than nonswitchers and are not riskier than other bank borrowers. Switchers also obtain better loan terms from banks compared with first-time bank borrowers without a credit history.
Has the Fed Responded to House and Stock Prices? A Time-Varying Analysis
Authors: Aastveit Knut Are , Furlanetto Francesco , Loria Francesca 
Published: November 2021

Abstract
We investigate whether the Federal Reserve has responded systematically to house and stock prices and whether this response has changed over time using a Bayesian structural VAR model with time-varying parameters and stochastic volatility. To recover the systematic component of monetary policy, we interpret the interest rate equation in the VAR as an extended monetary policy rule responding to inflation, the output gap, house prices, and stock prices. Our results indicate that the systematic component of monetary policy in the United States responded to real stock price growth significantly but episodically, mainly around recessions and periods of financial instability, and took real house price growth into account only in the years preceding the Great Recession. Around half of the estimated response captures the predictor role of asset prices for future inflation and real economic activity, while the remaining component reflects a direct response to stock prices and house prices.
Class Rank and Long-Run Outcomes
Authors: Denning Jeffrey T. , Murphy Richard , Weinhardt Felix 
Published: November 2021

Abstract
This paper considers an unavoidable feature of the school environment, class rank. What are the long-run effects of a student's ordinal rank in elementary school? Using administrative data on all public school students in Texas, we show that students with a higher third-grade academic rank, conditional on achievement and classroom fixed effects, have higher subsequent test scores, are more likely to take AP classes, graduate from high school, enroll in and graduate from college, and ultimately have higher earnings nineteen years later. We also discuss the necessary assumptions for the identification of rank effects and propose new solutions to identification challenges. The paper concludes by exploring the trade-off between higher-quality schools and higher rank in the presence of these rank-based peer effects.
Omitted Variable Bias of Lasso-Based Inference Methods: A Finite Sample Analysis
Authors: Wüthrich Kaspar , Zhu Ying 
Published: November 2021

AbstractWe study the finite sample behavior of Lasso-based inference methods such as post–double Lasso and debiased Lasso. We show that these methods can exhibit substantial omitted variable biases (OVBs) due to Lasso's not selecting relevant controls. This phenomenon can occur even when the coefficients are sparse and the sample size is large and larger than the number of controls. Therefore, relying on the existing asymptotic inference theory can be problematic in empirical applications. We compare the Lasso-based inference methods to modern high-dimensional OLS-based methods and provide practical guidance.
Summoning Aratron
Authors: Skemer Don C. 
Published: November 2021

Abstract
The article concerns a German magic roll of ca. 1700: Oxford, Bodleian Library, Bodley MS. Germ. F. (5) R. It was compiled and written chiefly in German, with some Latin and Hebrew, for a gentleman or aristocrat, referenced and portrayed within the roll, to serve both as a textual amulet and prayer roll. The complex text is based on celestial spirits, seals and sigils, and Christian prayer, apotropaic texts, and religious imagery. The article discusses the Bodley roll’s provenance, internal organization, compilation, source texts, Paracelsian and other influences, and its hybrid function as a way to understand how magic survived and evolved in the Germanic world during the Age of Reason.