bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-cell RNA transcriptome analysis reveals CXCL16/CXCR6 as maintenance factors for CNS tissue resident T cells that drive synapse elimination during viral recovery
Authors: Rosen Sarah F. , Soung Allison L. , Yang Wei , Ai Shenjian , Kanmogne Marlene , Davé Veronica A. , Prabhakar Sairam , Swain Amanda , Artyomov Maxim , Magee Jeffrey A. , Klein Robyn S. 
Published: October 2021

AbstractBackgroundEmerging RNA viruses that target the central nervous system (CNS) lead to cognitive sequelae in survivors. Studies in humans and mice infected with West Nile virus (WNV), a re-emerging RNA virus associated with learning and memory deficits, revealed microglial-mediated synapse elimination within the hippocampus. Moreover, CNS resident memory T (TRM) cells activate microglia, limiting synapse recovery and inducing spatial learning defects in WNV-recovered mice. The signals involved in T cell-microglia interactions are unknown.MethodsHere, we examined the murine WNV-recovered forebrain using single-cell RNA sequencing to identify putative ligand-receptor pairs involved in intercellular communication between T cells and microglia. Clustering and differential gene analyses were followed by protein validation, genetic and antibody-based approaches utilizing an established murine model of WNV recovery in which microglia and complement promote ongoing hippocampal synaptic loss.ResultsProfiling of host transcriptome at 25 days post-infection revealed a shift in forebrain homeostatic microglia to activated subpopulations with transcriptional signatures that have previously been observed in studies of neurodegenerative diseases. Importantly, CXCL16/CXCR6, a chemokine signaling pathway involved in TRM cell biology, was identified as critically regulating CXCR6 expressing CD8+ TRM cell numbers within the WNV-recovered forebrain. We demonstrate that CXCL16 is highly expressed by all myeloid cells, and its unique receptor, CXCR6, is highly expressed on all CD8+ T cells. Using genetic and pharmacological approaches, we demonstrate that CXCL16/CXCR6 is required not only for the maintenance of WNV-specific, CD8 TRM cells in the post-infectious CNS, but also contributes to their expression of TRM cell markers. Moreover, CXCR6+CD8+ T cells are required for glial activation and ongoing synapse elimination.ConclusionsWe provide a comprehensive assessment of the role of CXCL16/CXCR6 as an interaction link between microglia and CD8+ T cells that maintains forebrain TRM cells, microglial and astrocyte activation, and ongoing synapse elimination in virally recovered animals. We also show that therapeutic targeting of CXCL16 during recovery may reduce CNS CD8+ TRM cells.
Predicting student performance in a blended learning environment using learning management system interaction data
Authors: Fahd Kiran , Miah Shah Jahan , Ahmed Khandakar 
Published: October 2021

Purpose
Student attritions in tertiary educational institutes may play a significant role to achieve core values leading towards strategic mission and financial well-being. Analysis of data generated from student interaction with learning management systems (LMSs) in blended learning (BL) environments may assist with the identification of students at risk of failing, but to what extent this may be possible is unknown. However, existing studies are limited to address the issues at a significant scale.

Design/methodology/approach
This study develops a new approach harnessing applications of machine learning (ML) models on a dataset, that is publicly available, relevant to student attrition to identify potential students at risk. The dataset consists of the data generated by the interaction of students with LMS for their BL environment.

Findings
Identifying students at risk through an innovative approach will promote timely intervention in the learning process, such as for improving student academic progress. To evaluate the performance of the proposed approach, the accuracy is compared with other representational ML methods.

Originality/value
The best ML algorithm random forest with 85% is selected to support educators in implementing various pedagogical practices to improve students’ learning.
What motivates Vietnamese enterprises to upgrade in global value chains? Closing the intention-behavior gap
Authors: Hoang Dung Phuong , Doan Ngoc Thang , Nguyen Thi Cam Thuy 
Published: October 2021

PurposeUpgrading in global value chains (GVCs) has become a crucial strategy for enhancing competitive advantage and attaining higher profitability, especially among firms in developing countries. Drawn from the sociological approach, this study treats GVC upgrading as an entrepreneurial act and examines factors affecting firms' intention to move up in their chains based on the theory of planned behavior. The authors also further test the moderating effects of firms' knowledge about rule of origin and governmental supports on the intention-behavior gap.Design/methodology/approachIn-depth interviews with eight Vietnamese business managers were implemented to support the development of hypotheses and measurement scales. Afterwards, the authors conducted a survey on decision-makers of 402 Vietnamese firms which currently have export-import activities to collect quantitative data for testing the hypothesized relationships.FindingsThe empirical results indicate that both attitudes, behavioral control and social norms have significant positive impacts on the intention to upgrade in GVCs. In turn, such intention could further activate actual behaviors to move up in their chains. However, those who have better knowledge about rule of origin and receive governmental supports either in terms of finance, credit or technology have a higher probability of demonstrating actual behavior to upgrade in GVCs once their intentions are formed than those who do not.Practical implicationsThis research provides valuable implications for policymakers in accelerating firms' actions to upgrade within their chains, hence, actively enhancing not only organizational performance but also significantly contributes to the national economic development.Originality/valueWhile most of the previous studies examine the preconditions for firms to participate and upgrade in their GVCs, there is limited attention on determinants of firms' own intention and actual behavior to upgrade in their chains once they have participated in the GVC. Specifically, this research not only contributes to the existing knowledge regarding factors affecting firms' intention to upgrade in their chains but also closes the gap between the intention and the actual GVC upgrading behavior.
The hybrid career concept: creating hybrid career pathways
Authors: Gander Michelle 
Published: October 2021

PurposeHybrid career has been discussed in the literature for some time but is still an emergent concept. The study investigated the careers of university professional staff working in universities in Australia and the UK to better understand the careers of this underresearched cohort of staff. The findings were used to extend the theory of the hybrid career.Design/methodology/approachA total of 139 career stories were collected via an open-ended question in an online survey. Inductive thematic analysis was used to create themes and theorise career pathways relevant to the participants' careers.FindingsIt was found that participants had a hybrid career orientation (HCO) based on their essential values and their reciprocal relationship with their employer. Four career pathways emerged from the data: intra-organisational advancement, inter-organisational advancement, work–life balance and dead end.Research limitations/implicationsThere is a need for future research to investigate the HCO, both to add depth to the understanding of careers for university professional staff in universities and to examine the hybrid concept in other settings.Practical implicationsIt is suggested that by grouping staff into career pathways, human resource practitioners could provide more targeted interventions to ensure that staff are motivated and productive for the benefit of the organisation.Originality/valueThe research has extended the concept of the hybrid career and discovered four career pathways relevant to university professional staff.
The dilemma of winners: market power, industry competition and subsidy efficiency
Authors: Song Jialin , Su Yiyi , Su Taoyong , Wang Luyu 
Published: October 2021

Purpose
The purpose of this paper is, from a resource accumulation and resource allocation perspective, to examine the variant effects of government subsidies among firms with varying levels of market power and to test how industry competition moderates the relationship between market power and allocative efficiency of government subsidies.

Design/methodology/approach
This study explores the relationship between government subsidies and firm performance from a resource-based view. The authors study the moderating role of market power and three-way interaction between subsidy, market power and industry competition on firm performance. The authors test their hypotheses using a sample of Chinese A-share manufacturing firms from 2006–2019. The authors apply firm-level panel data regressions and conduct a series of robustness tests. The marginal effect of market power and industry competition is explored via three-way moderator effect models.

Findings
This study finds that government subsidies are negatively related to firm performance. Market power, on average, strengthens the negative effect of government subsidies on performance, but such a reinforcement effect is neutralized when industry competition is intense. Government subsidies are least efficiently used when firms have market power and industry competition is low. In addition, the authors use different forms of firm performance and a various of robustness tests to verify their assumptions.

Originality/value
This paper contributes to the literature as follows. First, the authors look into subsidy–performance problem from the perspective of the resource-based view and contribute to explaining and mitigating the divergence of current findings on the subsidy–performance relationship. Second, the authors introduce market power and industry competition as moderators to study how resource allocative efficiency affects the subsidy–performance relationship. Third, the authors propose that managerial incentives have played an important role in the allocation of government subsidies, which enriches management practices.
Definitions of work-life balance in childfree dual-career couples: an inductive typology
Authors: Boiarintseva Galina , Ezzedeen Souha R. , Wilkin Christa 
Published: October 2021

PurposeWork-life balance experiences of dual-career professional couples with children have received considerable attention, but there remains a paucity of research on the definitions of work-life balance among dual-career professional couples without children. This qualitative investigation sheds light on childfree couples' lives outside of work and their concomitant understanding of work-life balance.Design/methodology/approachThe study draws on interviews with 21 dual-career professional couples in Canada and the US, exploring their non-work lives and how they conceive of work-life balance.FindingsThematic analyses demonstrate that this group, while free of child rearing responsibilities, still deals with myriad non-work obligations. These couples also defy uniform characterization. The inductive investigation uncovered four couple categories based on the individual members' career and care orientations. These included careerist, conventional, non-conventional and egalitarian couples. Definitions of work-life balance varied across couple type according to the value they placed on flexibility, autonomy and control, and their particular level of satisfaction with their work and non-work domains.Originality/valueThis study contributes to research at the intersection of work-life balance and various demographic groups by exploring the work-life balance of professional dual-career couples without children. Using an interpretive ontology, the study advances a typology of childfree dual-career professional couples. The findings challenge the rhetoric that these couples are primarily work-oriented but otherwise carefree. Thus, this study demonstrates ways that childfree couples are different as well as similar to those with children.
The Greek life-long learning centers in the post-debt crisis era: evaluation of the effectiveness of mentoring in adult trainers training
Authors: Dukakis Nick , Chasioti Angeliki , Valkanos Efthymios , Staboulis Miltiadis , Fragkoulis Iosif 
Published: October 2021

PurposeThe purpose of this paper is to explore the views of Greek Life-Long Learning Centers (LLLCs) trainers, who worked as educational managers and took on informal mentoring roles in the context of counseling guidance and their trainees (who are adults’ trainers), on the effectiveness of mentoring in the post-Greek Debt Crisis era.Design/methodology/approachThe authors performed a quantitative analysis using the SPSS software package’s simple random sampling. The bibliographic review, the identification and specialization of the research objectives, as well as the study of the participants’ unique characteristics, were used in the construction of a research tool.FindingsThe majority of participants confirmed the importance of mentoring as a human resource strategy. Regarding its effectiveness in the field of the Greek LLLCs, there were several discrepancies in the perceptions of trainers and trainees, as well as specific malfunctions in its implementation.Research limitations/implicationsThe research omitted certain qualitative features and was conducted in a relatively limited geographical context.Originality/valueGiven the lack of similar studies in the field of the Greek LLLCs, this study illustrates the reality of the mentoring function in the training field of adult trainers, after the onset of the Greek economic crisis, while also highlighting realistic ways to improve the effectiveness of these organizations and conduct future, larger-scale research.
Exploring and measure the performance of the Indian petroleum supply chain
Authors: Kumar Sourabh , Barua Mukesh Kumar 
Published: October 2021

PurposeThis research identifies the supply chain performance indices and designs an evaluation framework to assess and compare the Indian petroleum supply chain performance. We presented a case study of three Indian petroleum companies. For this purpose, we identified fifteen performance criteria extracted from previous literature and expert inputs and classified them into four groups.Design/methodology/approachA fuzzy technique for order preference by similarity to the ideal solution (TOPSIS) method is employed for evaluating the performance of the Indian petroleum supply chain.FindingsThe design and evaluation framework suggests that the top three performance measurement criteria, the purity of the products, compliance with environmental laws, and new technology adoption. The result findings also indicate that company C contributes to a maximum satisfaction level of 77%. Simultaneously, companies A and B hold satisfaction levels of 72% and 67%.Practical implicationsThe managers should ensure that environmental standards, new technology adoption, and quality are significant concerns in the petroleum supply chain. The managers should follow national and international policies to preserve the environment and ensure safety in operational activities.Originality/valueThis paper makes two contributions in the domain of performance measurement of the petroleum supply chain. First, it identifies the prominent supply chain performance indices. Second, it proposes a model to assess and compare the performance of Indian petroleum companies.
A control chart based on Pearson residuals for a negative binomial regression: application to infant mortality data
Authors: García-Bustos Sandra , Cárdenas-Escobar Nadia , Debón Ana , Pincay César 
Published: October 2021

PurposeThe study aims to design a control chart based on an exponentially weighted moving average (EWMA) chart of Pearson's residuals of a model of negative binomial regression in order to detect possible anomalies in mortality data.Design/methodology/approachIn order to evaluate the performance of the proposed chart, the authors have considered official historical records of death of children of Ecuador. A negative binomial regression model was fitted to the data, and a chart of the Pearson residuals was designed. The parameters of the chart were obtained by simulation, as well as the performances of the charts related to changes in the mean of death.FindingsWhen the chart was plotted, outliers were detected in the deaths of children in the years 1990–1995, 2001–2006, 2013–2015, which could show that there are underreporting or an excessive growth in mortality. In the analysis of performances, the value of λ = 0.05 presented the fastest detection of changes in the mean death.Originality/valueThe proposed charts present better performances in relation to EWMA charts for deviance residuals, with a remarkable advantage of the Pearson residuals, which are much easier to interpret and calculate. Finally, the authors would like to point out that although this paper only applies control charts to Ecuadorian infant mortality, the methodology can be used to calculate mortality in any geographical area or to detect outbreaks of infectious diseases.
Statistical and intelligent reliability analysis of multi-layer ceramic capacitor for ground mobile applications using Taguchi’s approach
Authors: Bhargava Cherry , Sharma Pardeep Kumar 
Published: October 2021

PurposeAlthough Multi-Layer Ceramic Capacitors (MLCC) are known for its better frequency performance and voltage handling capacity, but under various environmental conditions, its reliability becomes a challenging issue. In modern era of integration, the failure of one component can degrade or shutdown the whole electronic device. The lifetime estimation of MLCC can enhance the reuse capability and furthermore, reduces the e-waste, which is a global issue.Design/methodology/approachThe residual lifetime of MLCC is estimated using empirical method i.e. Military handbook MILHDBK2017F, statistical method i.e. regression analysis using Minitab18.1 as well as intelligent technique i.e. artificial neural networks (ANN) using MATLAB2017b. ANN Feed-Forward Back-Propagation learning with sigmoid transfer function [3–10–1–1] is considered using 73% of available data for training and 27% for testing and validation. The design of experiments is framed using Taguchi’s approach L16 orthogonal array.FindingsAfter exploring the lifetime of MLCC, using empirical, statistical and intelligent techniques, an error analysis is conducted, which shows that regression analysis has 97.05% accuracy and ANN has 94.07% accuracy.Originality/valueAn intelligent method is presented for condition monitoring and health prognostics of MLCC, which warns the user about its residual lifetime so that faulty component can be replaced in time.
Abegar indigenous conflict resolution system: a community‐based reconciliation
Authors: Lake Beneyam 
Published: October 2021

Purpose
This paper aims to investigate the Abegar indigenous conflict resolution system based on community reconciliation in Haberu Woreda, North Wollo.

Design/methodology/approach
This study has used a qualitative research design and descriptive nature. The study collected primary data from different informants by using such qualitative data collection techniques as an interview, focus group discussions and observation to achieve the research objectives.

Findings
Accordingly, the finding of the study revealed that Abegars indigenous conflict resolution system aims at the restoration of order and harmony of the community. The types of conflicts presented and resolved in the community are inter-personal, homicide, inter-group in nature, which stemmed from the abduction of girls and women, violation of social values, theft, conflict over claims of a girl, competition over ownership of land and drunkenness. The findings further show that family reconciliation, blood reconciliation (dem maderk) and compensation performance are the major community reconciliation procedures (methods) of conflict management used by the studied community depending on the nature and types of conflicts.

Originality/value
This symbolic and practical significance to established trust between conflicting parties that their relationship is restored.
Measuring market orientation, innovative marketing strategies and performance: evidence from the Malaysian agro-food manufacturers
Authors: Kamarulzaman Nitty Hirawaty , Khairuddin Nurul Hasyima , Hashim Haslinda , Hussin Siti Rahayu 
Published: October 2021

PurposeThis paper aims to investigate the relationship between market orientation and innovative marketing strategies and the effect of innovative marketing strategies on the performance of agro-food manufacturers.Design/methodology/approachSystematic random sampling was used, and semi-structured interviews were conducted with 380 agro-food manufacturers. Several statistical analyses, including Pearson correlation analysis and logistic regression analysis, were used to analyze the relationship between market orientation and innovative marketing strategies, and the effect of innovative marketing strategies on the performance of agro-food manufacturers.FindingsAll dimensions of market orientation – customer orientation, competitor orientation and inter-functional coordination – have significant relationships with innovative marketing strategies (product, price, promotion and distribution), while customer orientation and promotion showed a very strong relationship among other variables measured. Innovative marketing strategies, specifically promotion, had the most effect on the performance of agro-food manufacturers.Research limitations/implicationsThe sample for this study was selected among agro-food manufacturers in major locations in Peninsular Malaysia. Hence, the findings may only give an initial overview of the current state of the agro-food manufacturers.Originality/valueThis study highlighted the significance of market orientation and innovative marketing strategies for the betterment of performance in the agro-food manufacturing sector.
The Roman fish tanks of the Western Mediterranean basin as potential scenarios for research on sea-level changes
Authors: Caballero-Rubio Francisco Javier , Viñals María José , Tormo-Esteve Santiago 
Published: October 2021

PurposeThis paper analyses Roman fish tanks, which have functional elements that could be used to research on palaeo-sea-levels. Thus, the conditions of 37 installations in the Western Mediterranean basin are reviewed to identify those that have the best environmental and constructive conditions to be analyzed.Design/methodology/approachThe methodology was largely based on the review of existing scientific bibliography dealing with sea-level variations from studies on historical constructions, existing historical documentation on Roman fish tanks on the Mediterranean coast, as well as the fieldwork carried out in fish tanks on the Mediterranean coasts.FindingsThe Roman coastal fish tanks located in the shoreline of the Western Mediterranean Sea have turned out to be an excellent indicator of sea-level changes. Nevertheless, current coastal retreat, erosion and storm surges are posing significant threats to their preservation, and they could be considered as a heritage at risk of disappearance. Moreover, variations in the tectonic behaviour of the different coastal sectors make it challenging to select these facilities as an indicator of the sea level.Originality/valueThe analysis of Late Holocene sea-level changes and palaeoenvironments from archaeological and biological evidences, although not without difficulties, is very convenient because it provides very precise data that cannot be obtained with other absolute dating methods. This approach is increasingly gaining popularity with researchers and is very innovative in its method of combining the results of several scientific disciplines.