bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of solid-phase organic carbon on the sorption of hydrophobic organic pollutants in landfill barriers, UK
Authors: Huang Pin-Ru , Stringfellow Anne , Smallman Dave , Marshall John 
Published: May 2021

AbstractThe Oxford Clay from Bletchley, the Kimmeridge Clay from Kimmeridge Bay, Dorset, and Tertiary mud (Wittering Formation) from Whitecliff, Isle of Wight, United Kingdom were used as sorbent samples because of their distinctive organic material characteristics (Amorphous organic matter rich and/or phytoclast rich). Organic material was isolated for identification and analysis using a non-acid extraction method (heavy liquid) extraction and traditional methods involving HF digestion. These organic materials were then used to determine influences of extraction on hydrophobic organic contaminants, (toluene and naphthalene) sorption. Organic petrology classification was applied to identify the various types of isolated organic material. Amorphous organic matter from the Kimmeridge Clay displayed a higher sorption capacity (Sorption–desorption distribution coefficient (Kd), Kd = 6,481, 59, 670; for toluene and naphthalene, respectively) compared to literature values. Amorphous organic matter-rich sorbent extracts demonstrated a higher absorption capacity than the phytoclast-rich sorbents (e.g., Wittering Formation, Kd = 219, 10, 134; for toluene and naphthalene, respectively). Implications of results in landfill design/risk assessment and modelling are discussed.
COVID-19 and the selection problem in national cause-of-death statistics
Authors: Lindahl B. I. B. 
Published: May 2021

AbstractThe World Health Organization has issued international instructions for certification and classification (coding) of the coronavirus disease (COVID-19) as cause of death. Central to these instructions is the selection of the underlying cause of death for a public health preventive purpose. This article focuses on two rules for this selection: (1) that a death due to COVID-19 should be counted independently of pre-existing conditions that are suspected of triggering a severe course of COVID-19 and (2) that COVID-19 should not be considered as due to anything else. The article argues that observance of the first rule may not always lead to an optimal selection from a preventive point of view and that in the future the ascertainment of an animal source of the coronavirus (SARS-CoV-2) would make it possible to reconceptualize ‘COVID-19′ and create a zoonotic classification code by means of which a factor of a greater preventive value could be selected than what is currently possible.
Die Sectionarbe im gynäkologischen Ultraschall
Authors: Brezinka Christoph 
Published: May 2021

ZusammenfassungBei Sectioraten von bis zu 40 % werden viele Frauen im Rahmen eines gynäkologischen Routineultraschalls eine Sectionarbe aufweisen. Die Größe der in der Folge der Sectio entstandenen Nische im Gewebe kann beurteilt und vermessen werden. Dies ist nicht nur in Bezug auf eine geplante weitere Schwangerschaft wichtig, zahlreiche Frauen haben durch Nischenbildungen in der Sectionarbe Zwischenblutungen, Fluor und Schmerzen. Beim Legen von IUD (intrauterine device [„Spirale“]) und bei der Durchführung von Inseminationen kann eine Sectionarbe zu einer „fausse route“ und einer Perforation verleiten. Das Erkennen und Dokumentieren von Sectionarben sollte ein fixer Bestandteil des gynäkologischen Ultraschalls und des Ultraschalls in der Frühschwangerschaft sein.
Controversial information spreads faster and further than non-controversial information in Reddit
Authors: Jasser Jasser , Garibay Ivan , Scheinert Steve , Mantzaris Alexander V. 
Published: May 2021

AbstractOnline users discuss and converse about all sorts of topics on social networks. Facebook, Twitter, Reddit are among many other networks where users can have this freedom of information sharing. The abundance of information shared over these networks makes them an attractive area for investigating all aspects of human behavior on information dissemination. Among the many interesting behaviors, controversiality within social cascades is of high interest to us. It is known that controversiality is bound to happen within online discussions. The online social network platform Reddit has the feature to tag comments as controversial if the users have mixed opinions about that comment. The difference between this study and previous attempts at understanding controversiality on social networks is that we do not investigate topics that are known to be controversial. On the contrary, we examine typical cascades with comments that the readers deemed to be controversial concerning the matter discussed. This work asks whether controversially initiated information cascades have distinctive characteristics than those not controversial in Reddit. We used data collected from Reddit consisting of around 17 million posts and their corresponding comments related to cybersecurity issues to answer these emerging questions. From the comparative analyses conducted, controversial content travels faster and further from its origin. Understanding this phenomenon would shed light on how users or organization might use it to their help in controlling and spreading a specific beneficiary message.
Association of Bicycle-Related Genital Numbness and Female Sexual Dysfunction: Results From a Large, Multinational, Cross-Sectional Study
Authors: Lui Hansen , Mmonu Nnenaya , Awad Mohannad A. , Namiri Nikan K. , Zheng Micha Y. , Amend Gregory M. , Eisenberg Michael L. , Breyer Benjamin N. 
Published: May 2021

Abstract

Introduction
Cycling can lead to microtrauma due to increased perineal pressure, possibly contributing to genital numbness and sexual dysfunction in female cyclists.

Aim
We aim to explore the associations between cycling characteristics, female genital numbness, and female sexual dysfunction.

Methods
We conducted a cross-sectional study on female cyclists and sexual wellness. Participants were recruited through Facebook® advertisements and online outreach at athletic clubs. Participants were asked about their cycling characteristics, genital numbness, and female sexual function using the Female Sexual Function Index (FSFI). Univariate and multivariable linear and logistic regression were used to assess risk factors for genital numbness and the association between genital numbness and the FSFI.

Outcome Measures
The outcome measures were cycling characteristics, questions regarding numbness (intensity, duration, location), and the FSFI score.

Results
Eight-hundred and seventy-five women were included in the study. Total lifetime miles cycled, biking duration, frequency, distance, speed, and biking surface were not significantly associated with genital numbness. Higher handlebar height was associated with less numbness. The prevalence of sexual dysfunction in the cohort was 52%. Genital numbness was significantly associated with sexual dysfunction (OR: 1.43, 95% CI: 1.05 – 1.95). Sub-group analysis for location of numbness demonstrated significant increase in risk for sexual dysfunction in cyclists who described numbness aro‘und the perineum (OR: 2.72, 95% CI: 1.05 – 7.02) and the vulva (OR: 1.55, 95% CI: 1.13 – 2.13). There was also a significant increase in the risk of sexual dysfunction in cyclists who reported a longer duration of numbness (OR: 6.58, 95% CI: 2.27 – 19.07).

Conclusions
Genital numbness is common in women who cycle and is associated with increased risk of FSD and lower average sexual response scores on FSFI.
Diet quality in middle-aged and older women with and without body weight dissatisfaction: results from a population-based national nutrition survey in Switzerland
Authors: Chatelan Angéline , Carrard Isabelle 
Published: May 2021

Abstract
Body weight dissatisfaction is associated with unhealthy dietary behaviours in young adults, but data are scarce regarding how this relationship evolves with age. The objectives of the present study were to assess the prevalence of body weight dissatisfaction and the association between body weight dissatisfaction, nutrient intake and diet quality in middle-aged and older women. We used data of a population-based sample of 468 middle-aged (50–64 y/o) and older (65–75 y/o) women, extracted from the cross-sectional 2014–15 Swiss National Nutrition Survey. Body weight dissatisfaction was assessed by questionnaire. Dietitians assessed dietary intakes using two non-consecutive computer-assisted multi-pass 24-h dietary recalls and performed anthropometric measurements. Nutrient intakes were calculated and compared with national dietary guidelines, and diet quality scored with the 2010 Alternate Healthy Eating Index (2010-AHEI). 41⋅1 % of women reported body weight dissatisfaction, and 49⋅8 % wanted to lose weight. Body weight dissatisfaction was associated with weight loss desire and a higher body mass index (BMI; P < 0⋅001). Women with body weight dissatisfaction consumed significantly less carbohydrates and dietary fibres, even when BMI was controlled for (P < 0⋅05). They also fell short of national dietary guidelines for magnesium and iron. Body weight dissatisfied women obtained lower 2010-AHEI scores than satisfied women (β −4⋅36, 95 % CI −6⋅78, −1⋅93). However, this association disappeared when the BMI was introduced in the equation. This highlights the importance of targeting both body dissatisfaction and unhealthy eating in obesity prevention and treatment at all ages.
New perspectives on Aspersentis Megarhynchus (Acanthocephala: Heteracanthocephalidae) from Notothenia Coriiceps Richardson (Nototheniidae) in the West Antarctic, with emended generic diagnosis
Authors: Amin O.M. , Heckmann R.A. , Dallarés S. , Constenla M. , Rubtsova N.Yu. , Kuzmina T. 
Published: May 2021

Abstract
A number of variable descriptive accounts of Aspersentis megarhynchus (von Linstow, 1892) Golvan, 1960 have been reported from specimens collected from many species of fish in various locations off Antarctic islands. We have described a new population from Notothenia coriiceps Richardson (Nototheniidae) off Galindez Island, West Antarctica, and features not previously reported, resolved the taxonomic controversies and nomenclature, and emended and updated the generic diagnosis taking into account the newly observed structures. These are depicted in microscopic images and include the outer spiral wall of the proboscis receptacle, the thicker dorsal wall of the receptacle compared to the ventral wall, parts of the female reproductive system, the separate cement gland ducts, the dorsal position of the male gonopore and more detail of proboscis hooks and trunk spines. It is surprising that the newly observed features were missed from the many descriptions of A. megarhynchus created since the original description. The variability in A. megarhynchus is noted with a comparison of the morphometrics of our specimens vs. those in six other descriptions. We also analysed the metal composition of hooks and spines using energy-dispersive X-ray analysis and concluded a molecular characterization of the species based on 18S DNA gene, with related phylogenetic analyses.
Using Mendelian randomization analysis to better understand the relationship between mental health and substance use: a systematic review
Authors: Treur Jorien L. , Munafò Marcus R. , Logtenberg Emma , Wiers Reinout W. , Verweij Karin J. H. 
Published: May 2021

AbstractBackgroundPoor mental health has consistently been associated with substance use (smoking, alcohol drinking, cannabis use, and consumption of caffeinated drinks). To properly inform public health policy it is crucial to understand the mechanisms underlying these associations, and most importantly, whether or not they are causal.MethodsIn this pre-registered systematic review, we assessed the evidence for causal relationships between mental health and substance use from Mendelian randomization (MR) studies, following PRISMA. We rated the quality of included studies using a scoring system that incorporates important indices of quality, such as the quality of phenotype measurement, instrument strength, and use of sensitivity methods.ResultsSixty-three studies were included for qualitative synthesis. The final quality rating was ‘−’ for 16 studies, ‘– +’ for 37 studies, and ‘+’for 10 studies. There was robust evidence that higher educational attainment decreases smoking and that there is a bi-directional, increasing relationship between smoking and (symptoms of) mental disorders. Another robust finding was that higher educational attainment increases alcohol use frequency, but decreases binge-drinking and alcohol use problems, and that mental disorders causally lead to more alcohol drinking without evidence for the reverse.ConclusionsThe current MR literature increases our understanding of the relationship between mental health and substance use. Bi-directional causal relationships are indicated, especially for smoking, providing further incentive to strengthen public health efforts to decrease substance use. Future MR studies should make use of large(r) samples in combination with detailed phenotypes, a wide range of sensitivity methods, and triangulate with other research methods.
Design of a new multi-epitope vaccine against Brucella based on T and B cell epitopes using bioinformatics methods
Authors: Chen Zhiqiang , Zhu Yuejie , Sha Tong , Li Zhiwei , Li Yujiao , Zhang Fengbo , Ding Jianbing 
Published: May 2021

Abstract
Brucellosis is one of the most serious and widespread zoonotic diseases, which seriously threatens human health and the national economy. This study was based on the T/B dominant epitopes of Brucella outer membrane protein 22 (Omp22), outer membrane protein 19 (Omp19) and outer membrane protein 28 (Omp28), with bioinformatics methods to design a safe and effective multi-epitope vaccine. The amino acid sequences of the proteins were found in the National Center for Biotechnology Information (NCBI) database, and the signal peptides were predicted by the SignaIP-5.0 server. The surface accessibility and hydrophilic regions of proteins were analysed with the ProtScale software and the tertiary structure model of the proteins predicted by I-TASSER software and labelled with the UCSF Chimera software. The software COBEpro, SVMTriP and BepiPred were used to predict B cell epitopes of the proteins. SYFPEITHI, RANKpep and IEDB were employed to predict T cell epitopes of the proteins. The T/B dominant epitopes of three proteins were combined with HEYGAALEREAG and GGGS linkers, and carriers sequences linked to the N- and C-terminus of the vaccine construct with the help of EAAAK linkers. Finally, the tertiary structure and physical and chemical properties of the multi-epitope vaccine construct were analysed. The allergenicity, antigenicity and solubility of the multi-epitope vaccine construct were 7.37–11.30, 0.788 and 0.866, respectively. The Ramachandran diagram of the mock vaccine construct showed 96.0% residues within the favoured and allowed range. Collectively, our results showed that this multi-epitope vaccine construct has a high-quality structure and suitable characteristics, which may provide a theoretical basis for future laboratory experiments.
Mental illness among 500 people living homeless and referred for psychiatric evaluation in Lisbon, Portugal
Authors: Monteiro Fernandes Ana , Gama Marques João , Bento António , Telles-Correia Diogo 
Published: May 2021

AbstractBackgroundOur goal was to identify the demographic profile of the people living homeless with mental illness in Lisboa, Portugal, and their relationship with the national healthcare system. We also tried to understand which factors contribute to the number and duration of psychiatric admissions among these homeless people.MethodsWe used a cross-sectional design, collecting data for 4 years among homeless people, in Lisboa, Portugal, that were referred as possible psychiatric patients to Centro Hospitalar Psiquiátrico de Lisboa (CHPL). In total, we collected data from 500 homeless people, then cross-checked these people in our CHPL hospital electronic database and obtained 467 patient matches.ResultsThe most common psychiatric diagnosis in our sample was drug abuse (34%), followed by alcohol abuse (33%), personality disorder (24%), and acute stress reaction (23%). Sixty-two percent of our patients had multiple diagnoses, a subgroup with longer follow-ups, more psychiatric hospitalizations, and longer psychiatric hospitalizations. The prevalence of psychotic disorders was high: organic psychosis (17%), schizophrenia (15%), psychosis not otherwise specified (14%), and schizoaffective disorder (11%), that combined altogether were present in more than half (57%) of our homeless patients.ConclusionThe people living homeless with multiple diagnoses have higher mental health needs and worse determinants of general health. An ongoing effort is needed to identify and address this subgroup of homeless people with mental illness to improve their treatment and outcomes.
Characterization of 1Sty13, a novel high-molecular-weight glutenin subunit from Elymus sibiricus L.
Authors: Yan Mei , Li Muzi , Yang Zaidong , Yu Feng , Du Xuye 
Published: May 2021

AbstractHigh-molecular-weight glutenin subunit (HMW-GS) is a key factor affecting dough-processing quality. 1Sty13 is a novel HMW-GS found in the tetraploid species, Elymus sibiricus L. 1Sty13 has faster electrophoretic mobility than the 1Dy12 subunit on sodium dodecyl sulphate (SDS)-polyacrylamide gel electrophoresis. The gene encoding the 1Sty13 subunit was composed of 1803 nucleotide base pairs with an open reading frame that was 599 amino acids in length. Analysis of the predicted amino acid sequence of 1Sty13 indicated that the N-terminal domain was similar to the y-type subunit, whereas the C-terminal domains were similar to the x-type subunit. Five cysteine residues were found in 1Sty13, which is one less than the published HMW-GS in the St genome. The 1Sty13 protein was purified at a scale sufficient for incorporation into flour for the SDS sedimentation test, which indicated that incorporating 1Sty13 improved dough quality.
Measurements of Total OH Reactivity During CalNex‐LA
Authors: Hansen R. F. , Griffith S. M. , Dusanter S. , Gilman J. B. , Graus M. , Kuster W. C. , Veres P. R. , de Gouw J. A. , Warneke C. , Washenfelder R. A. , Young C. J. , Brown S. S. , Alvarez S. L. , Flynn J. H. , Grossberg N. E. , Lefer B. , Rappenglueck B. , Stevens P. S. 
Published: May 2021

AbstractTotal OH reactivity was measured during the California Research at the Nexus of Air Quality and Climate Change field campaign at the Pasadena ground site using a turbulent flow tube reactor with laser‐induced fluorescence detection of the OH radical. Collocated measurements of volatile organic compounds (VOCs), inorganic species, and meteorological parameters were made and used to calculate the total OH reactivity, which was then compared to the measured values. An analysis of the OH reactivity measurements finds that although the measured reactivity correlated well with the calculated reactivity, the measurements were consistently greater than the calculations for all times during the day, with an average missing OH reactivity of 8–10 s−1, accounting for approximately 40% of the measured total OH reactivity. An analysis of correlations with both anthropogenic tracers of combustion and oxygenated VOCs as well as air trajectories during the campaign suggest that the missing OH reactivity was likely due to a combination of both unmeasured local emissions and unmeasured oxidation products transported to the site. Approximately 50% of the missing OH reactivity may have been due to emissions of unmeasured volatile chemical products, such as pesticides, cleaning agents, and personal care products.
Effect of Slit/Robo signaling on regeneration in lung emphysema
Authors: Park Jin-Soo , Cho RyeonJin , Kang Eun-Young , Oh Yeon-Mok 
Published: May 2021

AbstractEmphysema, a pathological component of chronic obstructive pulmonary disease, causes irreversible damage to the lung. Previous studies have shown that Slit plays essential roles in cell proliferation, angiogenesis, and organ development. In this study, we evaluated the effect of Slit2 on the proliferation and migration of mouse lung epithelial cells and its role in regeneration in an emphysema lung mouse model. Here, we have shown that Slit2/Robo signaling contributes to the regeneration of lungs damaged by emphysema. Mouse epithelial lung cells treated with Slit2 exhibited increased proliferation and migration in vitro. Our results also showed that Slit2 administration improved alveolar regeneration in the emphysema mouse model in vivo. Furthermore, Slit2/Robo signaling increased the phosphorylation of ERK and Akt, which was mediated by Ras activity. These Slit2-mediated cellular signaling processes may be involved in the proliferation and migration of mouse lung epithelial cells and are also associated with the potential mechanism of lung regeneration. Our findings suggest that Slit2 administration may be beneficial for alveolar regeneration in lungs damaged by emphysema.
Base-edited CAR T cells for combinational therapy against T cell malignancies
Authors: Georgiadis Christos , Rasaiyaah Jane , Gkazi Soragia Athina , Preece Roland , Etuk Aniekan , Christi Abraham , Qasim Waseem 
Published: May 2021

AbstractTargeting T cell malignancies using chimeric antigen receptor (CAR) T cells is hindered by ‘T v T’ fratricide against shared antigens such as CD3 and CD7. Base editing offers the possibility of seamless disruption of gene expression of problematic antigens through creation of stop codons or elimination of splice sites. We describe the generation of fratricide-resistant T cells by orderly removal of TCR/CD3 and CD7 ahead of lentiviral-mediated expression of CARs specific for CD3 or CD7. Molecular interrogation of base-edited cells confirmed elimination of chromosomal translocations detected in conventional Cas9 treated cells. Interestingly, 3CAR/7CAR co-culture resulted in ‘self-enrichment’ yielding populations 99.6% TCR−/CD3−/CD7−. 3CAR or 7CAR cells were able to exert specific cytotoxicity against leukaemia lines with defined CD3 and/or CD7 expression as well as primary T-ALL cells. Co-cultured 3CAR/7CAR cells exhibited highest cytotoxicity against CD3 + CD7 + T-ALL targets in vitro and an in vivo human:murine chimeric model. While APOBEC editors can reportedly exhibit guide-independent deamination of both DNA and RNA, we found no problematic ‘off-target’ activity or promiscuous base conversion affecting CAR antigen-specific binding regions, which may otherwise redirect T cell specificity. Combinational infusion of fratricide-resistant anti-T CAR T cells may enable enhanced molecular remission ahead of allo-HSCT for T cell malignancies.
Deeply learned broadband encoding stochastic hyperspectral imaging
Authors: Zhang Wenyi , Song Hongya , He Xin , Huang Longqian , Zhang Xiyue , Zheng Junyan , Shen Weidong , Hao Xiang , Liu Xu 
Published: May 2021

AbstractMany applications requiring both spectral and spatial information at high resolution benefit from spectral imaging. Although different technical methods have been developed and commercially available, computational spectral cameras represent a compact, lightweight, and inexpensive solution. However, the tradeoff between spatial and spectral resolutions, dominated by the limited data volume and environmental noise, limits the potential of these cameras. In this study, we developed a deeply learned broadband encoding stochastic hyperspectral camera. In particular, using advanced artificial intelligence in filter design and spectrum reconstruction, we achieved 7000–11,000 times faster signal processing and ~10 times improvement regarding noise tolerance. These improvements enabled us to precisely and dynamically reconstruct the spectra of the entire field of view, previously unreachable with compact computational spectral cameras.