bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Quality of Life and Its Relationship With Systemic Family Dynamics and Mental Health in Senior High School Students from Shaanxi, China
Authors: Yang Zhe , Shang YiJiang , Liang Ying , Zhang Haiyue , Yang Yifan , Wang Yue , Shang Lei , Zhang Yuhai 
Published: October 2021

Abstract
Objective: To explore the quality of life (QoL) status of senior high school students in the Shaanxi Province and the relationship of the QoL with systemic family dynamics and mental health. Methods: This was a cross-sectional observational study in a sample of 1402 senior high school students; students were asked to complete a questionnaire which comprised the 36-item Short Form Health Survey (SF-36) to assess the QoL, the Self-rating Scale of Systemic Family Dynamics (SSFD) for assessing family functioning, the Symptom Checklist-90-Revised (SCL-90-R) for assessing mental health and general demographic variables. Results: Grades of senior high school students were defined as Grade 1 (first year), Grade 2 (second year), and Grade 3 (third year). Compared to Grade 3 students, Grade 1 students had higher scores in physical functioning, role-emotional, bodily pain, and reported health transition of the QoL over the last one year (P < 0.05). Multiple linear regression showed that the place of residence, subscales of systemic family dynamics, somatization, and depression significantly affected the total QoL score. The results of SEM show that the SCL-90-R score fully mediated the association between the SSFD score and SF-36 score (indirect effect coefficient 0.055; 95% CI, 0.012–0.106; P = 0.042). Conclusion: The QoL score of senior high school students was low, particularly that of Grade 3 students, who consequently need more emotional support. By improving and enhancing systemic family dynamics, the QOL of high school students will improve and discovering and addressing their mental health problems will be easier.
Risk of vestibulocochlear disorders in patients with migraine or non-migraine headache
Authors: Lee Sang-Hwa , Kim Jong-Ho , Kwon Young-Suk , Lee Jae-June , Sohn Jong-Hee 
Published: October 2021

Abstract
Background

Headache, especially migraine, has been associated with various vestibular symptoms and several vestibular syndromes. In addition, cochlear disorders, such as tinnitus and hearing loss, have recently been reported to be more prevalent among migraine patients. However, whether headaches, including migraine or non-migraine headaches, are associated with vestibular and cochlear disorders remains unclear. Thus, the possible associations between headaches, including migraine and non-migraine headaches, and vestibulocochlear disorders were investigated in the present study.

Methods

Clinical data were analyzed from the Smart Clinical Data Warehouse of Hallym University Medical Center from 2011–2021. In patients with migraine and non-migraine headaches, data on Meniere`s disease (MD), benign paroxysmal positional vertigo (BPPV), vestibular neuronitis (VN), and cochlear disorders such as sensorineural hearing loss (SNHL) and tinnitus, were collected and compared with clinical data from controls without headache who had health check-ups. In addition, the presence of comorbidities were defined according to the International Classification of Diseases, tenth revision codes in the database and analyzed.

Results

The study included 15,128 participants with migraines and 76,773 with non-migraine headaches. Controls were identified based on propensity score matching (PSM). After PSM, the adjusted odds ratios (ORs) in subjects with migraine versus controls were 2.597 for MD (95% CI, 2.047–3.295; p < 0.001), 2.045 for BPPV (95% CI, 1.816–2.302; p < 0.001), 2.976 for VN (95% CI, 2.636–3.360; p < 0.001), 1.739 for SNHL (95% CI, 1.404–2.156; p < 0.001), and 1.970 for tinnitus (95% CI, 1.658–2.341; p < 0.001). The adjusted ORs for MD (1.771; 95% CI, 1.560–2.011; p < 0.001)), BPPV (1.731; 95% CI, 1.637–1.831; p < 0.001), VN (2.048; 95% CI, 1.935–2.168; p < 0.001), SNHL (1.396; 95% CI, 1.273–1.531; p < 0.001), and tinnitus (1.693; 95% CI, 1.569–1.826; p < 0.001) in patients with non-migraine headache versus controls were also high after PSM.

Conclusion

The present study findings indicated that migraine and non-migraine headaches are associated with an increased risk of cochlear disorders, such as SNHL and tinnitus, in addition to vestibular disorders.
The Role Of Sentinel Node Tumor Burden In Modeling The Prognosis Of Melanoma Patients With Positive Sentinel Node Biopsy: An Italian Melanoma Intergroup Study (N=2,086)
Authors: Tropea Saveria , Fiore Paolo Del , Maurichi Andrea , Patuzzo Roberto , Santinami Mario , Ribero Simone , Quaglino Pietro , Caliendo Virginia , Borgognoni Lorenzo , Sestini Serena , Giudice Giuseppe , Nacchiero Eleonora , Caracò Corrado , Cordova Adriana , Solari Nicola , Piazzalunga Dario , Tauceri Francesca , Carcoforo Paolo , Lombardo Maurizio , Cavallari Sara , Mocellin Simone 
Published: October 2021

Abstract
Background: The management of melanoma patients with metastatic sentinel nodes (SN) is evolving based on the results of trials questioning the impact of completion lymph node dissection (CLND) and demonstrating the efficacy of new adjuvant treatments. In this landscape, new prognostic tools for fine risk stratification are eagerly sought to optimize the therapeutic path of these patients. Methods: A retrospective cohort of 2,086 patients treated with CLND after a positive SN biopsy in thirteen Italian Melanoma Centers was reviewed. Overall survival (OS) was the outcome of interest; included independent variables were the following: age, gender, primary melanoma site, Breslow thickness, ulceration, sentinel node tumor burden (SNTB), number of positive SN, non-sentinel lymph nodes (NSN) status. Univariate and multivariate survival analyses were performed using the Cox proportional hazard regression model. Results: The 3-year, 5-year and 10-year OS rates were 79 %, 70% and 54%, respectively. At univariate analysis, all variables, except for primary melanoma body site, were found to be statistically significant prognostic factors. Multivariate Cox regression analysis indicated that older age (P< 0.0001), male gender (P= 0.04), increasing Breslow thickness (P <0.0001), presence of ulceration (P =0.004), SNTB size (P <0.0001) and metastatic NSN (P <0.0001) were independent negative predictors of OS. Conclusion: The above results were utilized to build a nomogram in order to ease the practical implementation of our prognostic model, which might improve treatment personalization.
Predicting machine’s performance data using the stacked long short-term memory (LSTM) neural networks
Authors: Dai Jianrong 
Published: October 2021

Abstract
Purpose

Machine Performance Check (MPC) is a daily quality assurance (QA) tool for Varian machines. The daily QA data based on MPC tests show machine performance patterns and potentially provide warning messages for preventive actions. This study developed a neural network model that could predict the trend of data variations quantitively.
Methods and materials:

MPC data used were collected daily for 3 years. The stacked long short-term memory (LSTM)model was used to develop the neural work model. To compare the stacked LSTM, the autoregressive integrated moving average model (ARIMA) was developed on the same data set. Cubic interpolation was used to double the amount of data to enhance prediction accuracy. After then, the data were divided into 3 groups: 70% for training, 15% for validation, and 15% for testing. The training set and the validation set were used to train the stacked LSTM with different hyperparameters to find the optimal hyperparameter. Furthermore, a greedy coordinate descent method was employed to combinate different hyperparameter sets. The testing set was used to assess the performance of the model with the optimal hyperparameter combination. The accuracy of the model was quantified by the mean absolute error (MAE), root-mean-square error (RMSE), and coefficient of determination (R2).
Results

A total of 867 data were collected to predict the data for the next 5 days. The mean MAE, RMSE, and \({\text{R}}^{2}\) with all MPC tests was 0.013, 0.020, and 0.853 in LSTM, while 0.021, 0.030, and 0.618 in ARIMA, respectively. The results show that the LSTM outperforms the ARIMA.
Conclusions

In this study, the stacked LSTM model can accurately predict the daily QA data based on MPC tests. Predicting future performance data based on MPC tests will foresee possible machine failure, allowing early machine maintenance and reducing unscheduled machine downtime.
IL-1β and IL-10: diagnostic and prognostic potential of cytokines in the assessment of progression of non-alcoholic fatty liver disease in patients with hypertension
Authors: Zhelezniakova Natalia , Rozhdestvenska Anastasiia 
Published: October 2021

Non-alcoholic fatty liver disease (NAFLD) affects about a quarter of the world's population and it is closely linked to hypertension (HT). Pro-inflammatory and anti-inflammatory cytokines play a key role in the pathology progression, and the search for non-invasive biomarkers for the diagnosis of NAFLD remains an important issue.
The aim of the study was to determine the diagnostic and prognostic value of IL-1β and IL-10 in assessing the progression of liver parenchyma changes in patients with NAFLD and HT comorbidity.
Materials and methods. A study of 115 patients with non-alcoholic steatohepatitis (NASH) was performed. The main group consisted of 63 patients with NASH and HT, 52 patients with isolated NAFLD represented the comparison group. Clinical and laboratory parameters were evaluated, IL-10 and IL-1β levels were measured by ELISA method, ultrasound steatometry and elastography were performed in all patients.
Results. The attenuation coefficient and median liver stiffness in NAFLD and HT group significantly exceeded the results in the isolated NAFLD group and in the control group. The IL-1β level in NAFLD and HT group was 17.55 pg/ml, and in isolated NAFLD group the indicator averaged 15.72 pg/ml, which exceeded the control values (8.26 pg/ml). IL-10 level was 12.69 pg/ml and 14.34 pg/ml in patients with comorbid and isolated NAFLD, respectively, while control results averaged 16.19 pg/ml. It were found strong relationship between IL-1β, IL-10 and CRP levels in patients with NAFLD and HT (r=0.61, p=0.024, and r=-0.69, p=0.036, respectively). Inverse correlations were also found between the cytokines IL-1β and IL-10 in NAFLD patients with and without HT (r=-0.61, p<0.001, and r=-0.57, p<0.001, respectively). Changes in the cytokine status of patients with NAFLD at different stages of steatosis and liver fibrosis had been identified.
Conclusions. The presence of concomitant HT in patients with NAFLD is associated with greater severity of liver parenchyma changes. NAFLD manifestation is accompanied by increase of IL-1β and decrease of IL-10 levels, and deepening of these deviations were found in patients with comorbidity of NAFLD and HT.
Interleukins IL-1β and IL-10 can be defined as biomarkers of NAFLD progression both in its isolated course and in its comorbidity with HT. The possibility of using biomarkers as an independent non-invasive test of diagnosing NAFLD requires further study.
Numerical assessment of the water-flow hazard to workers in the water disaster of underground mine
Authors: Wu Qiang , Yao Yi , Zhao Yingwang , Zhang Xiaoyan , Xu Hua , Du Yuanze , Du Zhili 
Published: October 2021

Abstract
Understanding the details of the water-flow hazard (WH) to workers in water disasters is extremely important in disaster-risk management. This paper aims to develop a numerical assessment model for the WH affecting worker safety. An assessment model of WH is proposed for water disasters in the underground mine, which includes two characteristics: (a) from water-disaster environment to WH of workers and (b) from multiple influencing factors to quantitative comprehensive quantification. To verify the feasibility of WH, it is applied to a water disaster in an underground coal mine. The simulation results highlight that the WH model can assess the hazard value of worker-1 (m = 72 kg, H = 1.72 m) at paragraph – 6134 and paragraph – 8840 of roadway, with different water-flow conditions, in the whole time of the disaster. Meanwhile, the differences between WH for three workers, worker-1, worker-2 (m = 95 kg, H = 1.82 m), and worker-3 (m = 60 kg, H = 1.62 m), under the same flow conditions are provided by the curve. Moreover, dynamic visualization of WH is achieved, which shows how the hazard of worker-1 changes into the time of 2, 5, 11, 19, and 27 h after a disaster in the full mine. Therefore, this numerical assessment can be used to evaluate the hazards posed by water flow to workers, which meets the urgent demands of water-disaster management for underground mines.
Impacts of urbanization and climate change on water quantity and quality in the Carp River watershed
Authors: Zango Baba-Serges , Seidou Ousmane , Sartaj Majid , Nakhaei Nader , Stiles Kelly 
Published: October 2021

Abstract
Pressure on water resources has reached unprecedented levels during the last decades because of climate change, industrialization, and population growth. As a result, vulnerability to inappropriate water availability and/or quality is increasing worldwide. In this paper, a Soil & Water Assessment Tool (SWAT) model of the Carp River watershed located in the city of Ottawa, Ontario was calibrated and validated. The model was then used to evaluate the individual and coupled impacts of urbanization and climate change on water quantity (discharge) and quality (nitrogen and phosphorus loads). While most of the watershed is currently rural, the headwaters will undergo rapid urbanization in the future, and there are concerns about possible negative impacts on water quantity and quality. Seven scenarios were developed to represent various watershed configurations in terms of land use and climate regime. Future climate time series were obtained by statistically downscaling the outputs of nine regional climate models, run under representative concentration pathways (RCP)4.5 and RCP8.5. The impacts were evaluated at the main outlet and at the outlet of an upstream sub-watershed that would be most affected by urbanization. Results show that climate change and urbanization's impacts vary greatly depending on the spatial scale and geographic location. Globally, the annual average discharge will increase between 6.75 and 9.34% by 2050, while changes in annual average nitrogen and phosphorus loads will vary between −1.20 and 24.84%, and 19.15 and 23.81%, respectively. Local impacts in sub-watersheds undergoing rapid urbanization would be often much larger than watershed-scale impacts.
Scour downstream of a corrugated apron under wall jets
Authors: Chaudhary Rakesh Kumar , Ahmad Zulfequar , Mishra Surendra Kumar 
Published: October 2021

Abstract
Experiments were performed over smooth and corrugated aprons with different corrugation dimensions to study the scour and flow characteristics under submerged wall jets condition. The scour depth and length are significantly lower for corrugated than smooth rigid aprons. The maximum reductions in scour depth and length are 79 and 83%, respectively. Optimum scour depth and length are found for aspect ratio (ratio of corrugation wave length to amplitude) three for corrugated apron. The factors affecting scour depth and length were analyzed graphically, and empirical equations are proposed for predicting maximum scour depth and length, and the point of maximum scour depth for corrugated aprons. Velocity, turbulence characteristics, and Reynolds stress in scour holes for smooth and corrugated aprons were also studied.
Hydrological peaks evaluation at Chitral and Tarbela stations, Pakistan, using combined Bayesian regularized neural network and signal difference average based variational mode decomposition method: A case study
Authors: Khan Mehwish Shafi , Hassan Syed Ahmad 
Published: October 2021

Abstract
Pakistan, being an agricultural country, highly depends on its natural water resources which originate from the upper regions of Hindu Kush-Karakoram-Himalaya Mountains and nourish one of the world's largest Indus Basin irrigation systems. This paper presents streamflow modelling and forecasting using signal difference average (SDA) based variational mode decomposition (VMD) combined with machine learning (ML) methods at Chitral and Tarbela stations on the Indus River network. For this purpose, VMD based random forest (VMD-RF), gradient boosting machine (VMD-GBM) and Bayesian regularized neural network (VMD-BRNN) have been chosen. Moreover, traditional time series flow models, that is seasonal autoregressive integrated moving average (SARIMA) and classical decomposition approach with particle swarm optimization-based support vector regression (PSO-SVR), are considered as benchmark models for comparison. The results show that overall, VMD-BRNN performed best, followed by VMD-GBM and VMD-RF, whereas SARIMA and PSO-SVR ranked last. Overall, SARIMA and PSO-SVR are failing to capture most of the peaks even during the training period whereas hybridization of VMD and ML methods has shown increased robustness of the models. The results show that the influential role of the high dimensional components and robustness on the river flow may be explored by most optimum SDA based VMD signals hybrid with BRNN method.
An efficient low-cost–low-technology whole-household water collection and treatment system
Authors: Okogwu O. I. , Elebe F. A. , Nwonumara G. N. 
Published: October 2021

Abstract
Most residents in developing countries suffer severe water shortage and often resort to self-supply. Unfortunately, some self-supply water sources contain disease-causing biological and chemical contaminants and require point-of-use (POU) treatment. However, recontamination and persistence of chemical contaminants occur, which defeats the aim of POU. This study aims to develop an affordable low-technology system that effectively treats whole-house water sourced from borehole and rain without recontamination. Raw borehole water (RBW) was treated with KAl(SO4)2·12H2O (8.10 mg/L), Ca(OH)2 (68.21 mg/L) and NaOCl (1.875 mg/L) in two separate tanks and thereafter filtered through 5-micron and 0.5-micron carbon filters, and a reverse osmosis system. The results showed that heterotrophic plate count (2,700 CFU/mL) and total coliform (378.00±21.25 MPN/100 mL) in RBW were reduced to zero, and total hardness was reduced by &gt;83% after treatment and there was no recontamination. Chromium (0.05±0.002 mg/L), Cu (0.04±0.001 mg/L), Pb (0.09±0.001 mg/L), Fe (0.26±0.005 mg/L) and Mn (0.2±0.001 mg/L) in the RBW were reduced below detectable limits after treatment. The annual per capita cost of water treatment was estimated at N 4,744.44 ($9.32) at per capita consumption of 100 L/day. Our technology shows exceptional promise in providing affordable and safe water to the entire household throughout the year.
Comprehensive assessment of urban water resources carrying capacity based on basin unit: a case study of Qingdao, China
Authors: Yang Ling , Wang Lin 
Published: October 2021

Abstract
With the quick development of social economy, the sharp contradiction between supply and demand of urban water resources is becoming much more obvious. Comprehensive assessment of urban water resources carrying capacity is of great significance to urban sustainable development planning. In this study, the urban water resources carrying capacity of Qingdao based on basin unit over 2010–2030 is predicted using analytic hierarchy process and system dynamics method. The results showed that the total water demand of all the nine basins have an upward annual trend from 2017 to 2030, among which the domestic water consumption increase obviously. The urban water resource carrying capacity indexes in all basins over 2017–2030 show a downward annual trend under the current social development model. So it is urgent to improve the water resource carrying capacity of each river basin by means of industrial structure optimization and upgrading and active development of new water sources.
Are Bacteriocins a Feasible Solution for Current Diverse Global
Problems?
Authors: González-Pérez Cristóbal Joel , Aispuro-Hernández Emmanuel , Vargas-Arispuro Irasema , Hernández-Mendoza Adrián , Ayala-Zavala Jesús Fernando , Martínez-Téllez Miguel Ángel 
Published: October 2021

Abstract:
The development of effective technologies to cope with persistent and progressive global
problems in human health and sustainable development has become an imperative worldwide
challenge. The search for natural alternatives has led to the discovery of bacteriocins, which are potent
protein antimicrobial compounds produced by most bacteria. The relevance of these molecules
is evidenced by more than 4,500 papers published in the last decade in Scopus indexed journals
highlighting their versatility and potential to impact various aspects of daily life, including the food
industry, medicine, and agriculture. Bacteriocins have demonstrated antibacterial, antifungal, antiviral,
and anticancer activities, and they also act as microbiota regulators and plant growth promoters.
This mini-review aims to provide insights into the current state and emerging roles of bacteriocins,
as well as their potential and limitations as feasible solutions against current diverse global
problems.
The Xiaogu San Attenuates Pain and Cartilage Damage in Rats with Monosodium
Iodoacetate Induced Osteoarthritis
Authors: Chen Rilan , Zhang Xiaoyun , Liao Zilong , Zhu Ying , Chen Yueping , Liu Jianhang , Chen Xia 
Published: October 2021

Background:
Osteoarthritis (OA) is a degenerative joint disease with an increasing incidence
associated with increased life expectancy. The application of traditional Chinese medicine in
the treatment of OA has become a research hotspot.

Objective:
This study investigated the effects of XGS externally applied to osteoarthritic joints and
analyze its effect on pain in monosodium iodoacetate (MIA)-induced OA rats. This study also
evaluates potential mechanisms behind the anti-osteoarthritic effects of XGS.

Methods:
A total of 24 Sprague Dawley rats were evenly and randomly divided into three separate
groups, including the normal control (NC), OA and XGS groups. MIA (50 μL, 10 mg/mL) was injected
into the left knee joints of the rats to induce OA. After 7 days, The rats of XGS group were
given XGS (0.45 g) that was externally applied to the left knee joint, were fixed with gauze, and
continuously administered XGS for 28 days. Morphological changes in tissues and organs were
examined using H&E staining. Biochemical indicators were measured using an automatic biochemical
analyzer. Inflammatory cytokines were detected using ELISA kits and immunohistochemistry.
RNA-based high-throughput sequencing (RNA-seq) was performed to detect differential
expression of mRNAs in normal and MIA–induced OA rats.

Results:
Stride of the left leg was extended in rats, matrix increased on cartilage tissue surfaces,
and inflammatory cytokines were reduced when treated with XGS. RNA-seq results revealed that
the PI3K-Akt signaling pathway is activated in the OA model. The qRT-PCR showed that the expression
levels of Tnn, Col6a6, Igf1 and Lamb1 were up-regulated by XGS.

Conclusions:
Altogether, this work demonstrated the potential therapeutic effects of XGS in rats
with OA induced by MIA. The XGS may be considered an alternative therapy to manage OA.