bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacts of field margin orientation on populations of soil‐dwelling invertebrates in relation to the direction and intensity of field traffic
Authors: Carlesso Léa , Beadle Andrew , Cook Samantha M. , Hartwell Graham , Mead Andrew , Ritz Karl , Sparkes Debbie , Wu Lianhai , Murray Phil J. 
Published: October 2021

AbstractSown field margins are a central part of agri‐environmental schemes aiming to improve biodiversity and ecosystem services in agricultural landscapes. Despite the knowledge that key services are delivered by belowground biodiversity, the impacts of field margins on populations of soil invertebrates both within the margins and the neighbouring crops remain unclear. We investigated the effect of field margin orientation with respect to the direction of the tramlines upon populations of soil‐dwelling mesofauna with focus on Acari (mites) and Collembola (springtails). Two margins on adjacent sides of the same field and their neighbouring cropped areas were examined: one margin oriented perpendicular to the tramlines, and one parallel to the tramlines. This sampling design was repeated on two farms with distinct soil management (no till vs. minimum tillage) and crop rotation (diverse‐long‐rotation vs. cereal/oilseed‐short‐rotation) in two seasons (autumn vs. spring) over two years. The distribution of invertebrates in the cropped areas depended on the orientation of the margins and the taxa studied. Reduced abundance of Collembola and Acari were found at both farms in the cropped area where machinery turns (margin perpendicular to tramlines), in comparison with the cropped area where margins and tramlines were parallel. This study suggests the existence of interacting impacts between the margins and field operations (trafficking and resulting compaction) on populations of soil mesofauna.
Toward an Understanding of Cognitive Mapping Ability Through Manipulations and Measurement of Schemas and Stress
Authors: Maxim Paulina , Brown Thackery I. 
Published: October 2021

AbstractDaily function depends on an ability to mentally map our environment. Environmental factors such as visibility and layout, and internal factors such as psychological stress, can challenge spatial memory and efficient navigation. Importantly, people vary dramatically in their ability to navigate flexibly and overcome such challenges. In this paper, we present an overview of “schema theory” and our view of its relevance to navigational memory research. We review several studies from our group and others, that integrate manipulations of environmental complexity and affective state in order to gain a richer understanding of the mechanisms that underlie individual differences in navigational memory. Our most recent data explicitly link such individual differences to ideas rooted in schema theory, and we discuss the potential for this work to advance our understanding of cognitive decline with aging. The data from this body of work highlight the powerful impacts of individual cognitive traits and affective states on the way people take advantage of environmental features and adopt navigational strategies.
Effect of Wave Instabilities in Thermal and Solutal Mixing of Double-Diffusive Opposed Jets Impinging in a Passive-Mixer
Authors: Khan Saleem A. , Hasan Nadeem 
Published: October 2021

Abstract
Two-dimensional (2D) numerical experiments are performed to investigate the flow instabilities and mixing of different nonisothermal counterflowing jets in a passive-mixer. The fluid is modeled as a binary mixture with thermal and solutal buoyancy effects considered through the Boussinesq approximation. The streams are arranged in a thermal and solutal buoyancy aiding configuration. Computations are carried out for three different ratios of the upper jet bulk velocity to the lower jet bulk velocity (VR), namely, VR = 0.5, 1.0, and 2. Within the parametric domain of RiT and RiC defined by region (RiT + RiC) ≤ 3, the instability causing transition from steady to unsteady flow regime is observed for VR = 1 and 2, while no transition is found to occur at VR = 0.5. Using Landau theory, it is established that the transition from steady to unsteady flow regime is a supercritical Hopf bifurcation. A complete regime map identifying the steady and unsteady flow regimes, within the parametric space of this study, is obtained by plotting the neutral curves of RiC and RiT (obtained using Landau theory) for different values of VR. Proper orthogonal decomposition (POD) analysis of the unsteady flows at VR = 1 establishes the presence of standing waves. However, for VR = 2, the presence of degenerate pairs in the POD eigenspectrum ascertains the presence of traveling waves in the unsteady flows. The standing wave unsteady flow mode is found to yield the highest rate of mixing.
Prognostic significance of drivers at work and learning styles in surgical training
Authors: Mellor Katie , Hopkins Luke , Robinson David Bryan Thomas , James Osian Penri , Luton Oliver , Brown Chris , Egan Richard John , Lewis Wyn G 
Published: October 2021

AbstractPurpose of the studyDrivers at work (DW) and Learning Styles (LS) refer to contentious theories that aim to account for differential career development yet seldom feature in assessment. This study aimed to quantify the influence of core surgical trainees’ (CST) DW and LS on career progress.Study designDW questionnaires and Kolb LS inventories were distributed to 168 CSTs during five consecutive induction boot camps in a single-statutory education body. Primary outcome measures were membership of the Royal College of Surgeons (MRCS) examination and national training number (NTN) success.ResultsOf 108 responses received (response rate 64.3%), 64.8% were male and 35.2% female (p=0.003). DW spectrum was: please people (25.0%), be perfect (21.3%), hurry up (18.5%), be strong (13.9%) and try hard (0%, p&lt;0.001). DW was either equivocal (n=14) or not provided (n=9) by 21.3% of CSTs. LS were: converging (34.3%), accommodating (28.7%), diverging (23.1%) and assimilating (13.9%, p=0.021). Men were more likely to be convergers (29/70, 41.4%), and women divergers (15/38, 39.5%, p=0.018) also preferring team-based LS (accommodating/diverging, 26/38 (68.4%) vs 30/70 (42.9%), p=0.010). MRCS success was not associated with DW (p=0.329) or LS (p=0.459). On multivariable analysis, NTN success was associated with LS (accommodators 64.5%, divergers 32.0%, OR 10.90, p=0.014), scholarly activity (OR 1.71, p=0.001), improving surgical training programme (OR 36.22, p=0.019) and universal ARCP 1 outcome (OR 183.77, p&lt;0.001).ConclusionsLS are associated with important differences in career progress with accommodator twofold more likely than diverger to achieve NTN.
The bi-compact-Gδ-open topology
Authors: Prasannan A. R. , Barkha  
Published: October 2021

This paper studies the bi-compact-[Formula: see text]-open topology on the family [Formula: see text] of all continuous functions from a completely regular space [Formula: see text] to the space [Formula: see text]. We compare this topology with open-point topology, bi-point-open topology and bi-compact-open topology and mention an example of a space asked in [P. Garg and S. Kundu, The compact-[Formula: see text]-open topology on [Formula: see text], Topology Appl. 159(8) (2012) 2082–2089] which satisfies [Formula: see text]. We also investigate submertrizability, mertrizability, separability, [Formula: see text]ech-completeness and Baire property of bi-compact-[Formula: see text]-open topology on [Formula: see text].
Phase structures and magnetostriction of Fe71.3Ga28.7 alloys prepared by different solidification rates
Authors: Mu Xing , Qi Yan , Yan Shaowen , Liu Yongqing , Cheng Chao , Xu Lihong , Zhang Hongping 
Published: October 2021

Magnetostrictive property shows anisotropic characteristics, which are related to phase structure and crystal orientation. In this paper, phase structures and magnetostrictive properties of Fe[Formula: see text]Ga[Formula: see text] at different solidification rates during zone-melting directional solidification were studied. Results show that when the solidification rate exceeds 72 mm/h, the sample has a single A2 structure. A multiphase structure of D03 and A2 is formed when the solidification rate is 36 mm/h. The multiphase structure of L12 and A2 emerges in the sample prepared with a solidification rate of 18 mm/h. The samples with L12 and A2 multiphase structure have excellent low-field magnetostrictive properties, reaching 68 × 10[Formula: see text] under a magnetic field of 20 kA/m.
Improved Adsorption Capacity of Nannochloropsis sp. through Modification with Cetyltrimethylammonium Bromide on the Removal of Methyl Orange in Solution
Authors: Buhani  , Suharso  , Miftahza Nurul , Permatasari Desy , Sumadi  
Published: October 2021

In this research, biomass modification of Nannochloropsis sp. with surfactant cetyltrimethylammonium bromide (CTAB) through a cation exchange reaction to produce adsorbent Nannochloropsis sp.-cetyltrimethylammonium bromide (AlgN-CTAB) has been carried out. Biomass modification of Nannochloropsis sp. by CTAB has been successfully carried out through confirmation from the analysis data produced by Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy and energy-dispersive X-ray spectroscopy (SEM-EDX). AlgN-CTAB adsorbent has been tested for its adsorption ability against anionic dye of methyl orange (MO) in solution by way of a sequence of experiments by the batch method. The optimum conditions for MO removal from the solution occurred at an adsorbent quantity of 0.1 g, pH of 5, and an interaction time of 60 min. MO adsorption kinetic data by AlgN and AlgN-CTAB tended to take the kinetic model of pseudo-second-order (PSO) with PSO rate constant ([Formula: see text]) values of 0.56 and 2.17 g mg-1 min-1, serially. The MO adsorption isotherm pattern by AlgN tends to take the Freundlich adsorption isotherm, whereas in AlgN-CTAB it follows the Langmuir and Dubinin-Radushkevich adsorption isotherms. The results of the adsorption-desorption of MO by AlgN-CTAB with 4 repetition cycles resulted in % removal of [Formula: see text]. The AlgN-CTAB adsorbent can be used repeatedly and is very effective in absorbing MO in water.
Novel Mechanisms of Exosome-Mediated Phagocytosis of Dead Cells in Injured Heart
Authors: Patil Mallikarjun , Saheera Sherin , Dubey Praveen K. , Kahn-Krell Asher , Kumar Govindappa Prem , Singh Sarojini , Tousif Sultan , Zhang Qinkun , Lal Hind , Zhang Jianyi , Qin Gangjian , Krishnamurthy Prasanna 
Published: October 2021

Rationale:
After myocardial ischemic injury, improper phagocytic clearance of dying cardiac cells and the ensuing lack of inflammation resolution results in adverse cardiac remodeling and dysfunction that might lead to heart failure. Therefore, therapeutic strategies to ameliorate immune cell phagocytic function are critical for augmenting cardiac repair after injury.

Objective:
To determine whether mesenchymal stem cell–derived exosomes (MSC-Exos) act as opsonin for apoptotic cells or trigger eat-me phagocytic signaling in resident/recruited phagocytes after myocardial ischemic injury.

Methods and Results:
We evaluated MSC-Exo–mediated opsonization of apoptotic cardiomyocytes and in vitro and in vivo effects of MFGE8 (milk fat globule epidermal growth factor-factor VIII)-deficient mouse MSC-Exo on macrophage engulfment of apoptotic cardiomyocytes and its implications on cardiac remodeling, repair, and function. Microscopy and FACS analyses show that opsonization of apoptotic cardiomyocytes with MSC-Exo enhances their engulfment by macrophages. Furthermore, preincubation of macrophages with MSC-Exo reprogrammed the signaling pathways involved in phagocytosis and expression of proreparative cytokines. Protein analysis of MSC-Exo reveals expression of MFGE8—a glycoprotein that bridges externalized phosphatidylserine on the apoptotic cell surface to αVβ3 or αVβ5 integrins on the phagocyte. Most intriguingly, siRNA inhibition of MFGE8 significantly reduced the MSC-Exo–mediated augmentation of dead cell engulfment, associated signaling, and proreparative phenotype. After myocardial ischemic injury, intramyocardial administration of MSC-Exo increases macrophage uptake of apoptotic bodies in the border zone of infarct and is associated with reduced proinflammatory response, increase in neovascularization, lower infarct size, and an improvement in cardiac function and MFGE8-deficient MSC-Exo administration failed to protect mice against myocardial infarction.

Conclusions:
Our data demonstrate that exosome-associated MFGE8 on one hand enhances opsonization of dead cells and on the other activates phagocytic signaling, thus augmenting removal of apoptotic cells, resolution of inflammation, and, therefore, efficient cardiac recovery after injury.
Drug‐Eluting or Bare‐Metal Stents for Left Anterior Descending or Left Main Coronary Artery Revascularization
Authors: Piccolo Raffaele , Bonaa Kaare H. , Efthimiou Orestis , Varenne Olivier , Urban Philip , Kaiser Christoph , Räber Lorenz , de Belder Adam , Remkes Wouter , van’t Hof Arnoud W. J. , Stankovic Goran , Lemos Pedro A. , Wilsgaard Tom , Reifart Jörg , Rodriguez Alfredo E. , Ribeiro Expedito E. , Serruys Patrick W. J. C. , Abizaid Alex , Sabaté Manel , Byrne Robert A. , de la Torre Hernandez Jose M. , Wijns William , Esposito Giovanni , Jüni Peter , Windecker Stephan , Valgimigli Marco ,   the Coronary Stent Trialists’ (CST) Collaboration
Published: October 2021

Background
New‐generation drug‐eluting stents (DES) reduce target‐vessel revascularization compared with bare‐metal stents (BMS), and recent data suggest that DES have the potential to decrease the risk of myocardial infarction and cardiovascular mortality. We evaluated the treatment effect of DES versus BMS according to the target artery (left anterior descending [LAD] and/or left main [LM] versus other territories [no‐LAD/LM]).

Methods and Results

The Coronary Stent Trialist (CST) Collaboration gathered individual patient data of randomized trials of DES versus BMS for the treatment of coronary artery disease. The primary outcome was the composite of cardiac death or myocardial infarction. Hazard ratios (HRs) with 95% CIs were derived from a 1‐stage individual patient data meta‐analysis. We included 26 024 patients across 19 trials: 13 650 (52.4%) in the LAD/LM and 12 373 (47.6%) in the no‐LAD/LM group. At 6‐year follow‐up, there was strong evidence that the treatment effect of DES versus BMS depended on the target vessel (
P
‐interaction=0.024). Compared with BMS, DES reduced the risk of cardiac death or myocardial infarction to a greater extent in the LAD/LM (HR, 0.76; 95% CI, 0.68–0.85) than in the no‐LAD/LM territories (HR, 0.93; 95% CI, 0.83–1.05). This benefit was driven by a lower risk of cardiac death (HR, 0.83; 95% CI, 0.70–0.98) and myocardial infarction (HR, 0.74; 95% CI, 0.65–0.85) in patients with LAD/LM disease randomized to DES. An interaction (
P
=0.004) was also found for all‐cause mortality with patients with LAD/LM disease deriving benefit from DES (HR, 0.86; 95% CI, 0.76–0.97).

Conclusions
As compared with BMS, new‐generation DES were associated with sustained reduction in the composite of cardiac death or myocardial infarction if used for the treatment of LAD or left main coronary stenoses.

Registration

URL:
https://www.crd.york.ac.uk/PROSPERO
; Unique identifier: CRD42017060520.
Bilirubin Nanoparticles Protect Against Cardiac Ischemia/Reperfusion Injury in Mice
Authors: Ai Wen , Bae Soochan , Ke Qingen , Su Shi , Li Ruijian , Chen Yanwei , Yoo Dohyun , Lee Eesac , Jon Sangyong , Kang Peter M. 
Published: October 2021

Background
Ischemia/reperfusion (I/R) injury causes overproduction of reactive oxygen species, which are the major culprits of oxidative stress that leads to inflammation, apoptosis, myocardial damage, and dysfunction. Bilirubin acts as a potent endogenous antioxidant that is capable of scavenging various reactive oxygen species. We have previously generated bilirubin nanoparticles (BRNPs) consisting of polyethylene glycol–conjugated bilirubin. In this study, we examined the therapeutic effects of BRNPs on myocardial I/R injury in mice.

Methods and Results
In vivo imaging using fluorophore encapsulated BRNPs showed BRNPs preferentially targeted to the site of I/R injury in the heart. Cardiac I/R surgery was performed by first ligating the left anterior descending coronary artery. After 45 minutes, reperfusion was achieved by releasing the ligation. BRNPs were administered intraperitoneally at 5 minutes before and 24 hours after reperfusion. Mice that received BRNPs showed significant improvements in their cardiac output, assessed by echocardiogram and pressure volume loop measurements, compared with the ones that received vehicle treatment. BRNPs treatment also significantly reduced the myocardial infarct size in mice that underwent cardiac I/R, compared with the vehicle‐treatment group. In addition, BRNPs effectively suppressed reactive oxygen species and proinflammatory factor levels, as well as the amount of cardiac apoptosis.

Conclusions
Taken together, BRNPs could exert their therapeutic effects on cardiac I/R injury through attenuation of oxidative stress, apoptosis, and inflammation, providing a novel therapeutic modality for myocardial I/R injury.
Inhibition of Aryl Hydrocarbon Receptor Attenuates Hyperglycemia‐Induced Hematoma Expansion in an Intracerebral Hemorrhage Mouse Model
Authors: Ren Reng , Lu Qin , Sherchan Prativa , Fang Yuanjian , Lenahan Cameron , Tang Lihui , Huang Yi , Liu Rui , Zhang John H. , Zhang Jianmin , Tang Jiping 
Published: October 2021

Background
Hyperglycemia is associated with greater hematoma expansion (HE) and worse clinical prognosis after intracerebral hemorrhage (ICH). However, the clinical benefits of intensive glucose normalization remain controversial, and there are no approved therapies for reducing HE. The aryl hydrocarbon receptor (AHR) has been shown to participate in hyperglycemia‐induced blood–brain barrier (BBB) dysfunction and brain injury after stroke. Herein, we investigated the role of AHR in hyperglycemia‐induced HE in a male mouse model of ICH.

Methods and Results
CD1 mice (n=387) were used in this study. Mice were subjected to ICH by collagenase injection. Fifty percent dextrose was injected intraperitoneally 3 hours after ICH. AHR knockout clustered regularly interspaced short palindromic repeat was administered intracerebroventricularly to evaluate the role of AHR after ICH. A selective AHR inhibitor, 6,2′,4′‐trimethoxyflavone, was administered intraperitoneally 2 hours or 6 hours after ICH for outcome study. To evaluate the effect of AHR on HE, 3‐methylcholanthrene, an AHR agonist, was injected intraperitoneally 2 hours after ICH. The results showed hyperglycemic ICH upregulated AHR accompanied by greater HE. AHR inhibition provided neurological benefits by restricting HE and preserving BBB function after hyperglycemic ICH. In vivo knockdown of AHR further limited HE and enhanced the BBB integrity. Hyperglycemia directly activated AHR as a physiological stimulus in vivo. The thrombospondin‐1/transforming growth factor‐β/vascular endothelial growth factor axis partly participated in AHR signaling after ICH, which inhibited the expressions of BBB‐related proteins, ZO‐1 and Claudin‐5.

Conclusions
AHR may serve as a potential therapeutic target to attenuate hyperglycemia‐induced hematoma expansion and to preserve the BBB in patients with ICH.
Stochastic Downscaling to Chaotic Weather Regimes using Spatially Conditioned Gaussian Random Fields with Adaptive Covariance
Authors: Prudden Rachel , Robinson Niall , Challenor Peter , Everson Richard 
Published: October 2021

AbstractDownscaling aims to link the behaviour of the atmosphere at fine scales to properties measurable at coarser scales, and has the potential to provide high resolution information at a lower computational and storage cost than numerical simulation alone. This is especially appealing for targeting convective scales, which are at the edge of what is possible to simulate operationally. Since convective scale weather has a high degree of independence from larger scales, a generative approach is essential. We here propose a statistical method for downscaling moist variables to convective scales using conditional Gaussian random fields, with an application to wet bulb potential temperature (WBPT) data over the UK. Our model uses an adaptive covariance estimation to capture the variable spatial properties at convective scales. We further propose a method for the validation, which has historically been a challenge for generative models.
“A Major Quality of Life Issue”: A Survey-Based Analysis of the Experiences of Adults With Laryngotracheal Stenosis with Mucus and Cough
Authors: Clunie Gemma M. , Anderson Catherine , Savage Matthew , Hughes Catherine , Roe Justin W. G. , Sandhu Gurpreet , McGregor Alison , Alexander Caroline M. 
Published: October 2021

Objectives: To investigate how the symptoms of mucus and cough impact adults living with laryngotracheal stenosis, and to use this information to guide future research and treatment plans. Methods: A survey was developed with the support of patient advisors and distributed to people suffering with laryngotracheal stenosis. The survey comprised 15 closed and open questions relating to mucus and cough and included the Leicester Cough Questionnaire (LCQ). Descriptive statistics, X2 and thematic analyses were completed. Results: In total, 641 participants completed the survey, with 83.62% (n = 536) reporting problems with mucus; 79% having daily issues of varying severity that led to difficulties with cough (46.18%) and breathing (20.90%). Mucus affected voice and swallowing to a lesser degree. Respondents described a range of triggers; they identified smoky air as the worst environmental trigger. Strategies to manage mucus varied widely with drinking water (72.26%), increasing liquid intake in general (49.35%) and avoiding or reducing dairy (45.32%) the most common approaches to control symptoms. The LCQ showed a median total score of 14 (interquartile range 11-17) indicative of cough negatively affecting quality of life. Thematic analysis of free text responses identified 4 key themes—the Mucus Cycle, Social impact, Psychological impact, and Physical impact. Conclusion: This study shows the relevance of research focusing on mucus and cough and its negative impact on quality of life, among adults with laryngotracheal stenosis. It demonstrates the inconsistent advice and management strategies provided by clinicians for this issue. Further research is required to identify clearer treatment options and pathways.