bluuebunny/crossref_metadata_2025_split huggingface dataset:
Partnered innovation to implement timely and personalized care: A case study
Authors: Proctor Enola K. , McKay Virginia R. , Toker Emre , Maddox Thomas M. , Hooley Cole , Lengnick-Hall Rebecca , MacGibbon Simon , Evanoff Bradley 
Published: April 2021

Abstract

Background:
Understanding how to translate research discoveries into solutions for healthcare improvement is a priority of NIH-funded Clinical and Translational Science Awards (CTSA). This study, supported by one CTSA, aims to capture one process of shaping and implementing innovations to advance the timeliness and patient-centeredness of cardiovascular care. Specifically, we sought to understand a partnership between a private digital health startup company, a university innovation lab, and an academic health system’s cardiology program pursuing this goal.

Findings:
The collaboration proceeded through clear phases to address the questions and challenges: problem definition, exploration and formalization of the partnership, innovation co-creation and pilot test, and scale-up planning. Phases were punctuated by key decisions, such as forming the partnership, negotiating terms of the partnership, iterating form and features of the innovation, and exploring sufficiency of its value-add for scale-up and sustainment. Key implementation concepts were apparent, including implementation strategies (e.g., champions and iterative trialing) and the implementation outcomes of acceptability, sustainment, and scale-up. Participants identified potential risks of collaboration, reflected on their co-creation process, and the value of engaging stakeholders in innovation design. Findings may inform subsequent collaborations between innovators and translational researchers.

Methods:
We conducted a case study to understand the partnership; characterize the questions they pursued, their decision points, information and data sources; and identify the challenges and risks. Data were collected through a series of four focus groups with members of each partnering organization. A transdisciplinary research team iteratively worked to condense and synthesize data from audio recorded transcripts into a case narrative.
Lee-Yang zeros of the antiferromagnetic Ising model
Authors: BENCS FERENC , BUYS PJOTR , GUERINI LORENZO , PETERS HAN 
Published: April 2021

AbstractWe investigate the location of zeros for the partition function of the anti-ferromagnetic Ising model, focusing on the zeros lying on the unit circle. We give a precise characterization for the class of rooted Cayley trees, showing that the zeros are nowhere dense on the most interesting circular arcs. In contrast, we prove that when considering all graphs with a given degree bound, the zeros are dense in a circular sub-arc, implying that Cayley trees are in this sense not extremal. The proofs rely on describing the rational dynamical systems arising when considering ratios of partition functions on recursively defined trees.
The European Fiscal Board: supranationalde novobody or orchestrator?
Authors: Tesche Tobias 
Published: April 2021

AbstractThe European Fiscal Board (EFB) is a supranational fiscal council advising the European Commission on the European Union (EU) fiscal framework. It was created as a response to the EU member states' repeated non-compliance with the EU fiscal rules and the emergence of national fiscal councils. Non-compliance with EU fiscal rules was often left unpunished and required a new expert body to regain some of the lost credibility of the EU's fiscal framework through enhanced fiscal monitoring. This article argues that the European Commission created the EFB in response to the new intergovernmental dynamics. A supranational fiscal watchdog that depends on the Commission for financial resources and access to information would deflect member states from delegating more competences away from the Commission. Thus, the Commission was able to counter a potential threat to its authority in EU fiscal governance by creating a supranationalde novobody that it controlled.
Digital Technology, Internet Research and Benefits of a Virtual Library
Authors: Akhtar Zia 
Published: April 2021

AbstractThe search of legal precedence orstare decisishas always distinguished the lawyer who is in professional practice. The development of the internet has led to a greater dimension in this research and to an empirical approach to understanding the application of law. The academic lawyer has always needed access to the newest legislation and case law and the online search engines are of increasing relevance to accessing the virtual library. This is necessary to assimilate because of the impact of law and technology which is not just of relevance to find texts but also the process of artificial intelligence that is of utility in forms of inquiry. It includes portals that can be sourced online, Lexis and Westlaw which have available software packages that are available for lawyers. The issue is if the technology is moving at excessive speed or is the momentum of digital technology sustainable within the profession. This article argues that legal software provides the means for artificial intelligence in an increasingly specialist field and it is necessary for professionals to stay equipped with knowledge updates on computer terminals in order to enhance their research or lose out in the information supply chain.
What comes to mind first? Feature type and order of production in a property generation task
Authors: VORANO AGOSTINA , VIVAS LETICIA , MENEGOTTO ANDREA 
Published: April 2021

abstractFew studies have explored in depth the mechanisms that underlie the execution of the property generation task, in spite of its importance and wide usage. The main exception to this is Santos, Chaigneau, Simmons, and Barsalou’s (2011) research: they claim that the two mechanisms at issue are word association and situated simulation. On the basis of the Linguistic and Situated Simulation theory, these researchers assert that word association is executed by a linguistic system, whilst situated simulation is executed by a situated simulation system. From these claims, the authors derive a series of predictions concerning the types of features that would be produced in the property generation task, and the order in which those types of features would appear. Our aim was to test those predictions, using an existent property generation database in Spanish. Our results are partially in accordance with Santos et al.’s results. The main divergence is related to the behavior of taxonomic superordinate features. We examine alternative explanations to account for this discrepancy. Furthermore, we criticize Santos et al.’s conception about what counts as a linguistic feature, and analyze alternative models about this issue.
Predicted structure of fully activated human bitter taste receptor TAS2R4 complexed with G protein and agonists
Authors: Yang Moon Young , Mafi Amirhossein , Kim Soo-Kyung , Goddard William A. , Guthrie Brian 
Published: April 2021

AbstractBitter taste is sensed by bitter taste receptors (TAS2Rs) that belong to the G protein-coupled receptor (GPCR) superfamily. In addition to bitter taste perception, TAS2Rs have been reported recently to be expressed in many extraoral tissues and are now known to be involved in health and disease. Despite important roles of TAS2Rs in biological functions and diseases, no crystal structure is available to help understand the signal transduction mechanism or to help develop selective ligands as new therapeutic targets. We report here the three-dimensional structure of the fully activated TAS2R4 human bitter taste receptor predicted using the GEnSeMBLE complete sampling method. This TAS2R4 structure is coupled to the gustducin G protein and to each of several agonists. We find that the G protein couples to TAS2R4 by forming strong salt bridges to each of the three intracellular loops, orienting the activated Gα5 helix of the Gα subunit to interact extensively with the cytoplasmic region of the activated receptor. We find that the TAS2Rs exhibit unique motifs distinct from typical Class A GPCRs, leading to a distinct activation mechanism and a less stable inactive state. This fully activated bitter taste receptor complex structure provides insight into the signal transduction mechanism and into ligand binding to TAS2Rs.
Towards refining World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations for red and processed meat intake: insights from Alberta’s Tomorrow Project cohort
Authors: Al Rajabi Ala , Lo Siou Geraldine , Akawung Alianu K. , McDonald Kathryn , Price Tiffany R. , Shen-Tu Grace , Robson Paula J. , Veugelers Paul J. , Maximova Katerina 
Published: April 2021

AbstractCurrent cancer prevention recommendations advise limiting red meat intake to <500 g/week and avoiding consumption of processed meat, but do not differentiate the source of processed meat. We examined the associations of processed meat derived from redv. non-red meats with cancer risk in a prospective cohort of 26 218 adults who reported dietary intake using the Canadian Diet History Questionnaire. Incidence of cancer was obtained through data linkage with Alberta Cancer Registry with median follow-up of 13·3 (interquartile range (IQR) 5·1) years. Multivariable Cox proportional hazards regression models were adjusted for covariates and stratified by age and sex. The median consumption (g/week) of red meat, processed meat from red meat and processed meat from non-red meat was 267·9 (IQR 269·9), 53·6 (IQR 83·3) and 11·9 (IQR 31·8), respectively. High intakes (4th Quartile) of processed meat from red meat were associated with increased risk of gastrointestinal cancer adjusted hazard ratio (AHR): 1·68 (95 % CI 1·09, 2·57) and colorectal cancers AHR: 1·90 (95 % CI 1·12, 3·22), respectively, in women. No statistically significant associations were observed for intakes of red meat or processed meat from non-red meat. Results suggest that the carcinogenic effect associated with processed meat intake may be limited to processed meat derived from red meats. The findings provide preliminary evidence towards refining cancer prevention recommendations for red and processed meat intake.
Substitution of unprocessed and processed red meat with poultry or fish and total and cause-specific mortality
Authors: Nielsen Tine Bjerg , Würtz Anne Mette Lund , Tjønneland Anne , Overvad Kim , Dahm Christina Catherine 
Published: April 2021

AbstractRecent studies found positive associations between intake of red meat and processed meat and total mortality; however, substitution of red meat with poultry and fish has been poorly investigated. We aimed to investigate associations for substitutions of red meat (unprocessed/processed) and total mortality and deaths due to cancer or CVD. We used data from the Danish Diet, Cancer and Health cohort, including 57 053 participants aged 50–64 years at baseline. Information on diet was collected through a validated 192-item FFQ. Information regarding total mortality, deaths due to cancer and deaths due to CVD was obtained by record linkage. Cox proportional hazards models were used to estimate the hazard ratio (HR) of 150 g/week substitutions of red meat with poultry or fish. During a follow-up (mean 16·1 years), 8840 deaths occurred (4567 were due to cancer; 1816 due to CVD). The adjusted HR for total death when substituting 150 g/week total red meat with poultry was 0·96 (95 % CI 0·95, 1·00) and with fish 0·99 (95 % CI 0·97, 1·01). Corresponding HR for cancer death or CVD death were similar. Substitution of processed red meat with fish or poultry was more consistently associated with a lower mortality than substitution of unprocessed red meat. For example, the adjusted HR for total death when substituting 150 g/week processed red meat with poultry was 0·95 (95 % CI 0·92, 0·98). We found that replacing processed red meat with poultry or fish was associated with a lower risk of total mortality and deaths due to cancer, but not deaths due to CVD.
Identifying the Effect of Stock Indexing: Impetus or Impediment to Arbitrage and Price Discovery?
Authors: Ahn Byung Hyun , Patatoukas Panos N. 
Published: April 2021

AbstractThe rise of stock indexing has raised concerns that index investing impedes arbitrage and degrades price discovery. This article uses Russell’s reconstitution to identify the causal effect of index investing on information arbitrage and price discovery. Although index investing has no discernible effect on the ability of arbitrageurs to trade and impound news into the prices of large- and mid-cap stocks, we find that index investing increases the speed of price adjustment to news for micro-cap stocks. Our causal evidence identifies the relaxation of arbitrage constraints as a mechanism through which indexing facilitates informed trading for more arbitrage-constrained micro-cap stocks.
Bilateral cochlear implantation in children: simultaneously or in consecutive sessions?
Authors: Dalgic A , Atsal G , Yildirim O , Edizer D T , Özay MB , Olgun L 
Published: April 2021

AbstractObjectiveThis study aimed to evaluate and compare cases of simultaneous and consecutive bilateral cochlear implantation from the perspective of the duration of anaesthesia, surgical complications and hospitalisation.MethodFifty patients with simultaneous bilateral cochlear implantation (group 1) and 47 patients with consecutive bilateral cochlear implantation (group 2) were included in this study. The two groups were compared in terms of the duration of anaesthesia, the duration of surgery, radiological findings, the complications and the post-operative hospitalisation time.ResultsGroup 1 had a significantly shorter operation time than group 2 (p < 0.01). The mean total operation time was 189 minutes in group 1. In group 2, the mean operation times for the first and second surgery were 134 minutes and 136 minutes, respectively, and the total operation time for both surgical procedures in group 2 was 270 minutes. The duration of post-operative hospitalisation of the patients in group 1 was significantly shorter than the total post-operative hospitalisation after both operations for the patients in group 2 (p < 0.01).ConclusionIn conclusion, if there is no anatomical problem that may lead to a prolonged operation time or any risk regarding anaesthesia, simultaneous bilateral cochlear implantation can be performed safely.
Establishment of suitable reference genes for studying relative gene expression during the transition from trophozoites to cyst-like stages and first evidences of stress-induced expression of meiotic genes inTrichomonas vaginalis
Authors: Peixoto Juliana Figueiredo , dos Santos Daniele Graças , Ribeiro Lupis , de Oliveira Vitor Silva Cândido , Nunes-da-Fonseca Rodrigo , Nepomuceno-Silva José Luciano 
Published: April 2021

AbstractTrichomonas vaginalisis a parasite of the human urogenital tract and the causative agent of trichomoniasis, a sexually transmitted disease of worldwide importance. This parasite is usually found as a motile flagellated trophozoite. However, when subjected to stressful microenvironmental conditions,T. vaginalistrophozoites can differentiate into peculiar cyst-like stages, which exhibit notable physiological resistance to unfavourable conditions. Although well documented in morphological and proteomic terms, patterns of gene expression changes involved in the cellular differentiation into cyst-like stages are mostly unknown. The real-time reverse transcription polymerase chain reaction (RT-qPCR) is recognized as a sensitive and accurate method for quantification of gene expression, providing fluorescence-based data that are proportional to the amount of a target RNA. However, the reliability of relative expression studies depends on the validation of suitable reference genes, which RNAs exhibit a minimum of variation between tested conditions. Here, we attempt to determine suitable reference genes to be used as controls of invariant expression during cold-inducedin vitrodifferentiation ofT. vaginalistrophozoites into cyst-like forms. Furthermore, we reveal that the mRNA from the meiotic recombinase Dmc1 is upregulated during this process, indicating that cryptic sexual events may take place in cyst-like stages ofT. vaginalis.
The role of characterisation in everyday voice engagement and AVATAR therapy dialogue
Authors: Ward Thomas , Lister Rachel , Fornells-Ambrojo Miriam , Rus-Calafell Mar , Edwards Clementine J. , O'Brien Conan , Craig Tom KJ , Garety Philippa 
Published: April 2021

AbstractBackgroundVoices are commonly experienced as communication with a personified ‘other’ with ascribed attitudes, intentionality and personality (their own ‘character’). Phenomenological work exploring voice characterisation informs a new wave of relational therapies. To date, no study has investigated the role of characterisation in behavioural engagement with voices or within psychological therapy for distressing voices.MethodsBaseline characterisation (the degree to which the voice is an identifiable and characterful entity) of the dominant voice was rated (high, medium or low) using a newly developed coding framework, for n = 60 people prior to starting AVATAR therapy. Associations between degree of characterisation and (i) everyday behavioural engagement with voices (The Beliefs about Voices Questionnaire-Revised; n = 60); and (ii) interaction within avatar dialogue [Session 4 Time in Conversation (participant–avatar); n = 45 therapy completers] were explored.ResultsThirty-three per cent reported high voice characterisation, 42% medium and 25% low. There was a significant association between characterisation and behavioural engagement [H(2) = 7.65, p = 0.022, ɛ2 = 0.130] and duration of participant–avatar conversation [F(2,42) = 6.483, p = 0.004, η2 = 0.236]. High characterisation was associated with increased behavioural engagement compared with medium (p = 0.004, r = 0.34; moderate effect) and low (p = 0.027, r = 0.25; small−moderate effect) with a similar pattern observed for the avatar dialogue [high v. medium: p = 0.008, Hedges’ g = 1.02 (large effect); high v. low: p = 0.023, Hedges' g = 1.03 (large effect)]. No differences were observed between medium and low characterisation.DiscussionComplex voice characterisation is associated with how individuals interact with their voice(s) in and out of therapy. Clinical implications and future directions for AVATAR therapy and other relational therapies are discussed.
Poverty and Sources of Income Support Among Older People With Disabilities and Out of Work: Comparison of Canada and the United Kingdom
Authors: CHEN WEN-HAO , BENTLEY LEE , WHITEHEAD MARGARET , MCALLISTER ASHLEY , BARR BENJAMIN 
Published: April 2021

AbstractThe debate about extending working lives in response to population ageing often overlooks the lack of employment opportunity for older adults with disabilities. Without work, their living standards depend heavily on government transfers. This study contributes to the literature on health inequalities by analysing the sources of income and poverty outcomes for people aged 50 to 64 in two liberal democratic countries yet with contrasting disability benefit contexts – Canada and the United Kingdom. This choice of countries offers the opportunity to assess whether the design of benefit systems has led the most disadvantaged groups to fare differently between countries. Overall, disabled older persons without work faced a markedly higher risk of poverty in Canada than in the UK. Public transfers played a much greater role in the UK, accounting for two-thirds of household income among low-educated groups, compared with one-third in Canada. The average benefit amount received was similar in both countries, but the coverage of disabled people was much lower in Canada than in the UK, leading to a high poverty risk among disabled people out of work. Our findings highlight the importance of income support systems in preventing the widening of the poverty-disability gap at older ages.
A Tentative Dissolution of Austria-Hungary: The 1914–15 Russian Occupation of Lviv in Polish Memory
Authors: Kożuchowski Adam 
Published: April 2021

AbstractThis article analyzes a collection of narratives concerning the Russian occupation of Lviv (Lwów, Lemberg), the capital of the Austrian Crownland Galicia, between September 1914 and June 1915 in the initial phase of World War I. These narratives were produced and published in Polish and German between 1915, when Lviv was still occupied, and 1935, sixteen years after it had been included in a reborn Poland. One might assume that the relatively uneventful occupation constituted a negligible experience in the context of the dramatic developments of this period: the Great War and the subsequent Polish-Ukrainian and Polish-Soviet wars. And yet, memories of the Russian occupation were tenaciously perpetuated and cultivated. In this article I attempt to answer the multipronged question: Why did the occupation attract so much attention, and from whom, and what made its memories survive the subsequent dramatic conflicts and changes of political regimes relatively intact? Hence, my analysis regards the formation of collective memories at the intersection of individual experiences, group and national identities, and strategies of accommodating the unpredictably changing political realities.
What can the abundance of Grey Parrots on Príncipe Island tell us about large parrot conservation?
Authors: Valle Simon , Collar Nigel J. , Melo Martim , Marsden Stuart J. 
Published: April 2021

AbstractWhile populations of the Endangered Grey Parrot Psittacus erithacus have collapsed across its range, the species remains remarkably abundant on the island of Príncipe, Gulf of Guinea. We examine how aspects of its ecology interplay with local environmental conditions, to inform conservation strategies for this species and other large parrots. On Príncipe, parrots breed in large trees of common species, with nest densities (42 ± 34 km−2) greatly exceeding those for any comparably sized parrot. Productivity is high (1.9 chicks per cavity), probably reflecting the absence of nest competitors and predators. Food sources are abundant and much of the island is inaccessible to trappers, so many nests are successful each year. Historically harvest has involved taking only chicks from trees in a few traditional patches. These conditions have combined to allow Grey Parrots to thrive on Príncipe, while elsewhere nest trees are timber targets, nest competition and nest predation are likely to be more intense, trapping is indiscriminate, and few areas remain unexploited by trappers. Preservation of large trees as breeding refugia, and vigilance against the indiscriminate trapping of adult birds, are identified as key conditions to stabilize and recover mainland Grey Parrot populations and indeed large parrots generally, given their very similar ecological traits and anthropogenic circumstances.