bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-Efficacy Mediates The Relationship Between Social Support And Psychological Resilience In Patients With Lung Cancer: A Cross-Sectional Study
Authors: Yin Yizhen , Zhang Jie , Lv Mengmemg , Li Hui , Li Huiyuan , Zhang Jingping 
Published: June 2021

Abstract
Purpose: The prognosis of patients with lung cancer might be influenced by mental health. Psychological resilience is one of the important indicators to reflect the psychological state. It has been shown that patients with higher social support and self-efficacy have better psychological resilience. The aim of this study was to determine whether or not self-efficacy mediates the relationship between social support and psychological resilience in patients with lung cancer.Methods: A cross-sectional study of 303 lung cancer patients was conducted. Participants completed questionnaires, including the Chinese version of the Perceived Social Support Seale Scale, the Chinese version of Strategies Used by People to Promote Health Scale, and the Chinese version of the Connor-Davidson Resilience Scale. Results: Mediation analysis indicated that self-efficacy had a partially mediating effect between social support and psychological resilience. Direct paths from social support to self-efficacy, self-efficacy to psychological resilience, and social support to psychological resilience were significant (p< 0.001). Moreover, indirect paths from social support to self-efficacy and self-efficacy to psychological resilience were also significant at the 95% level [0.120–0.550]; the mediating effect accounted for 38.16% of the total effect.Conclusions: Self-efficacy plays an important role in the relationships between social support and psychological resilience in cancer patients. Social support not only directly influenced the psychological resilience, but also indirectly influenced psychological resilience through self-efficacy.
Downregulation of AnnexinA5 Gene Expression in Coronary In-Stent Restenosis – A Pilot Study
Authors: Baktashian Mojtaba , Soflaei Sara Saffar , Salehi Mansoor , Moohebati Mohsen , Iravani Omid , Moghadam Mahsa Rastegar , Pasdar Alireza , Ghayour-Mobarhan Majid , Hashemi Mohammad 
Published: June 2021

Abstract
Background and aims:

In- stent restenosis (ISR) is the Achilles heel of angioplasty. AnnexinA5 as an anticoagulant has been shown have anti-inflammatory and anti-atherosclerotic effects. Here we aim to investigating the mRNA expression of AnnexinA5 in peripheral white blood cell of patients with in-stent restenosis.
Methods

Patients with the history of coronary stent implantation who candidate for re-angiography were entered the study and allocated into two groups according the results of re-angiography; in-stent restenosis (stenosis ≥ 50% in stent) and non-in-stent restenosis (stenosis < 50% in stent). Total RNA of WBC was extracted and cDNA was synthesized using commercial kits. AnnexinA5 expression was assessed with real time PCR and TaqMan probe and reported in relation with GAPDH as a housekeeping gene.
Result

AnnexinA5 expression was investigated in total 50 participants including 25 ISR and 25 non-ISR. Baseline characteristics including age, sex, smoking habits, hypertension, diabetes mellitus, dyslipidemia and stent in LAD were statistically the same in cases and controls. AnnexinA5 expression in ISR patients was 50% lower than controls.
Conclusion

AnnexinA5 is down-regulated in ISR and could be considered as a biomarker for predicting ISR and furthermore it could be used as prevention for ISR occurrence.
MiR-224 Promotes Lymphatic Metastasis by Targeting ANGPTL1 in Non-Small-Cell Lung Carcinoma
Authors: Han Haibo , Pan Bo , Liang Fan , Wu Lina , Liu Xijuan , Yang Yue , Chen Jin-feng 
Published: June 2021

Abstract
Background: MicroRNAs can regulates tumor metastasis either as an oncomiR or suppressor miRNA. Here, we investigate the role of miR-224 in lymphatic metastasis of non-small-cell lung cancer (NSCLC). Methods: The expression of miR-224 was demonstrated by a validation cohort of 156 lung cancer patients (77 cases with lymphatic metastasis) by q-PCR. In vitro and in vivo experiments were performed to study the malignant phenotype after upregulation and inhibition of miR-224 expression. Furthermore, the direct target genes of miR-224 were determined by a luciferase reporter assay. Results: miR-224 was identified as a high expression miRNA in the tumor tissues with lymphatic metastasis) with an area under the receiver operating characteristic curve (AUC) of 0.57. Forced expression of miR-224 in H1299 cells promoted not only the cell viability, plate clone formation, migration and invasion in vitro, but also tumor growth and lung metastasis in vivo. Consistently, inhibition of miR-224 suppressed the malignant characters both in vitro and in vivo. Molecular mechanism research suggested that miR-422a targeted the ANGPTL1 as a novel tumor suppressor.Conclusions: The present study demonstrates that miR-224 is a potential marker for the prediction of lymphatic metastasis of NSCLC. And application of miR-224 may help for prophylactic intervention of NSCLC in clinical practice.
Epigenetic Programming during thymic development sets the stage for optimal
function in effector T cells via DNA demethylation
Authors: Issuree Priya , Teghanemt Athmane , Pulipati Priyanjali , Day Kenneth , Yorek Matt , Yi Ren , Misel-Wuchter Kara , Keen Henry , Au Christy , Maretzky Thorsten , Gurung Prajwal , Littman Dan 
Published: June 2021

Abstract
The potential for early thymic developmental events to program epigenetic states that influence adult T cell physiology remains an important question in health. Herein using the Cd4 locus as a paradigm for early developmental programming, we demonstrate that DNA demethylation during thymic development is critical for the licensing of a novel stimulus-responsive element that serves to maintain CD4 gene expression in effector T cells. We document the importance of maintaining high CD4 expression during parasitic infection and show that by driving transcription, this stimulus-responsive element allows for the maintenance of H3K4me3 levels during T cell replication, which is critical for repelling de novo DNA methylation at the Cd4 promoter. A failure to undergo epigenetic programming during development leads to gene silencing during effector T cell replication, thus providing evidence that early development can program stimulus-responsive elements to propagate a stable epigenetic state in effector T cells, with important biological consequences.
Investigation of Symptom Status, Body Perception Levels and Symptoms of Anxiety and Depression in Breast Cancer Patients Receiving Paclitaxel: A Prospective Longitudinal Study
Authors: CEYLAN GAMZE GÖKÇE , METİN Zehra GÖK 
Published: June 2021

Abstract
Purpose: This study aimed to investigate symptom status, body perception level changes and the symptoms of anxiety and depression in breast cancer patients receiving Paclitaxel.Methods: This descriptive, and prospective study was conducted with 84 breast cancer patients receiving paclitaxel regimen. “Chemotherapy Symptom Assessment Scale (C-SAS)”, “Body Perception Scale (BPS)” and “Hospital Anxiety and Depression Scale (HADS)” were applied at five time points (T₁, T₂, T₃, T₄, T₅). Data was analyzed using descriptive statistics, Wilcoxon, Friedman, Cochrane Q and Spearman’s correlation tests.Results: The frequency of needling and numbness in hands and feet, pain, and skin or nail changes significantly increased in the subsequent assessment points (T₂, T₃, T₄, and T₅) compared to the initial assessment (T₁) (p<0.05). The mean scores of BPS significantly decreased at T₂, T₄, and T₅ (p<0.01). The mean scores of the anxiety subscale of the HADS scale decreased at the T2, T3, and T4 (p<0.01), and the mean scores of the depression subscale significantly increased at the T3, T4, and T5 (p<0.01).Conclusions: The findings underscore the need for oncology nurses to provide comprehensive training sessions on effective symptom management, changes in body perception levels, and alleviation of the symptoms of anxiety and depression in breast cancer patients receiving paclitaxel. In this way, the physiological symptom burden that occurs in patients may be alleviated, and negative changes in body perception, anxiety and depression symptoms may be decreased.
Development of a Novel Wireless Multi-Channel Stethograph System for Monitoring Cardiovascular and Cardiopulmonary Diseases
Authors: Zhang Xingzhe , Maddipatla Dinesh , Narakathu Binu B. , Bazuin Bradley J. , Atashbar Massood 
Published: June 2021

Abstract
A multi-channel stethograph system was designed and developed as an electronic auscultation system for graphic recording of heart, lung and trachea (HLT) sounds non-invasively through a set of 16 acoustic sensors. The multi-channel stethograph system was fabricated by placing 16 microphone based acoustic sensor in a CNC machined Delrin® housing cases that are covered using diaphragms. Among the 16 acoustic sensors, 14 were positioned in a memory foam pad and 2 were placed directly on the heart and trachea to acquire sounds simultaneously from the lungs, heart and trachea. The sounds acquired from the 16 acoustic sensors were processed through a custom designed and fabricated 16-channel PCB for signal conditioning. A National Instruments (NI) 9205 data acquisition device (DAQ) along with a NI 9191 wireless chassis was used to acquire and wirelessly transmit the data from the 16-channel PCB to a Wi-Fi enabled device such as a PC/tablet. A custom LabVIEW program was developed on a Wi-Fi enabled PC/tablet to record the data from the DAQ. In addition, a MATLAB program was developed to convert the recorded data from the acoustic sensors into 16 audio files (for audio playback) and plot the waveforms in time and frequency domain as well as spectrogram for visual examination of any abnormal patterns in inhalation and exhalation. This provides critical information on the presence of wheezes, crackles and rhonchi sounds as well as abnormal heartbeat and respiration rate which helps in analyzing the condition of heart and lungs. The graphically displayed HLT sounds will help physicians in the clinical diagnosis and monitoring of lung and heart disorders, particularly chronic obstructive pulmonary disease (COPD), asthma, pneumonia, and congestive heart failure by providing objective evidence.
Simulation and Computational Study of Graphene Oxide Nanocarriers Loaded in the Absorption and Release of the Anticancer Drug of Camptothecin
Authors: Moradi Omid , Mahdavian Leila 
Published: June 2021

Abstract
The structure of nano- graphene oxide, due to its special properties such as hydrophilicity, special surface and suitable biocompatibility, the possibility of high loading of hydrophilic and hydrophobic drugs, has attracted special attention in drug release. In this study, after simulating and optimizing the structure of nano-graphene and then nano-graphene oxide (NGO), it was used to load the anti-cancer drug of camptothecin (CA) in aqueous medium and the optimal conditions for achieving maximum loading efficiency of the drug were investigated. Due to the structure of the drug, there are two forms of lactone ring and carboxylate, which if the lactone ring form is predominant, the effectiveness of the drug is increased, which depends on the pH of environment. The calculated thermodynamic and structural results show that the solubility of the drug in relation to nano-graphene and its lactone ring state are maintained by using nano-graphene oxide. By folic acid as an intermediate in aqueous medium, the drug is released to form of lactone ring and is increased the effectiveness of drug. Lactony is maintained the drug structure and is increased the drug effectiveness. The results show that the presence of the ring in the drug structure and its binding to the mediator of folic acid to nano-graphene oxide is a stabilizing factor of keto tautomer. The calculation of vibrational frequencies show that the presence of folic acid intermediate reduces the vibrational frequency of the hydroxyl group (OH) so that its absorption energy (Ead) is equal to the lowest value 65.24 a.u.
The Role of Fiscal Policy in The Inflation: VAR Analysis of Kazakhstan’s Economy, 2005-2020
Authors: Ybrayev Zhandos 
Published: June 2021

Abstract
The paper analyzes the patterns of dynamic effects of fiscal policy to domestic inflation in the context of a small open economy. Using 4-variable (government spending, fiscal deficit, money stock (M2), and domestic inflation rate) vector autoregression model estimated with quarterly data for Kazakhstan’s economy in the period of 2005Q1-2020Q1. We distinguish between government expenditure on consumption and investment. As a result, we find that a fiscal policy shock have certain positive effects on the inflation rate. In particular, social protection spending adds 1% to the inflation rate in the following four quarters, while the government capital purchases do not produce sizable effect on inflation dynamics even in the longer term horizons. Overall, for the fiscal policy to become inflation-neutral, we suggest several policy recommendations.
Electrochemical Determination of Chloramphenicol in Milk and Eye-drop Using Easily Activated Screen Printed Carbon Electrodes
Authors: Hailu Tesfu , Tessema Merid , Li Yaw-Kuen 
Published: June 2021

Abstract
BackgroundAn analytical method that has fast response with cheap price and simple sample preparation is an ideal technique that the science need. An electrochemical sensor is an analytical method that suit for the above criteria to determine various samples using different electrode material. Providing detection method for chloramphenicol in farm product and drug sample using cheap electrode material is required due to its wide application in farm. ResultIn this study, direct and cost-effective activated SPCE was made electrochemically to determine chloramphenicol in eye-drop and pasteurized milk. The activation of the SPCE was straightforward and done by cycling 0.5 M KOH using LSV techniques. The employed surface imaging, spectroscopy, and electrochemical analysis show that there is an effective formation of new functional groups during the activation. The activated SPCE gave a superb current response for Chloramphenicol during the CV and SWV study using PBS of pH 6.5 compared to that of the bare one. Utilizing the optimal SWV conditions, a linear calibration curve was obtained using the range of 0.05‒100 µM with quite a small detection limit of 20 nM. ConclusionIn general, the higher sensitivity, stability and remarkable recovery results on the real sample analysis indicate that the activated screen printed carbon electrode can be applied to analyses sample in the field cause it have high stability, excellent reproducibility and long-term stability.
Short-Term Canopy and Long-Term Effects Soil of a Native Shrub Under Arid Bioclimate: A Case Study From Tunisia
Authors: Noumi Zouhaier , Mseddi Khalil , Mezghani Imed 
Published: June 2021

Abstract
Interactions between plants (competition and facilitation) in terrestrial ecosystems include: (1) short-term effects primarily quantified with experimental removals; and (2) long-term effects primarily quantified with observational methods. This study, conducted in the National Park of Bou Hedma, examined (1) the relative contributions of short-term canopy and long-term soil effects of a shrub species in explaining differences in biomass, species diversity (richness) and species density of understory plants (i) between shrubs and open areas, (ii) between shrubs and removed shrubs; and (2) the role of grazing in driving changes in direction of short-term and long-term effects in shrub/understory species interactions.Differences in species richness, density and biomass of understorey communities between shrub removed and open areas were mostly due to long-term soil effects, whereas differences beneath shrubs and shrub removed were due to short-term canopy effects, in particular on soil water content.Our study provides the positive effect of savannas shrubs on the understorey vegetation biomass, species density and diversity in arid ecosystems. Additionally, grazing by large herbivores negatively influenced the dynamics of vegetation under an arid bioclimate.
Socio-Cultural and Gender-Based Issues that Shape Sexuality of Emerging Adults in Nigeria: A Qualitative Approach
Authors: Adetutu Olufemi , Asa Sola , Solanke Bola , Aroke AbdulRahman Azeez , Okunlola David 
Published: June 2021

Abstract
Background Socio-cultural and gender-based issues influence sexuality of emerging adults. These gender-based issues worsen sexual health outcomes of emerging adults in studies outside Nigeria. Some of these issues are male dominance in sexual relationships, health care providers’ bias in attending to sexual health needs of emerging adults and age disparate sexual relationships. Studies have reported that males dominate females in sexual relationship largely in part owing to masculinity tendencies. Also, health care providers view emerging adults as randy when seeking information on sexual and reproductive health care services. Added to these is age disparate sexual relationships. Older men engage in exchanged sex while younger females are unable to negotiate condom. All these speak to gender and social inequality in sexual relationships are largely undocumented in Nigeria. Method This study collected information purposively using a qualitative inquiry. Thirty (30) in-depth interviews (IDIs), six (6) Focus Group Discussions (FGDs) and Eighteen (18) Key Informant Interviews (KIIs) were conducted across the three main ethnic groups in Nigeria. Result Narratives and interviews showed nuanced discourses of all these gendered issues. Males dominated females in sexual relationships through suppression to negotiate condom, diminished females’ individual agency, and engagement in multiple sexual partnerships. Females endured domination of males in sexual relationships to sustain relationships. Also, health providers were biased and indifferent in providing sexual and reproductive health services to emerging adults. This study showed poor socio-economic status makes older men to exploit and take advantage of younger females in sexual relationships. Wide age difference and the notion of fulfilling their side in a paid sexual intercourse made younger females unable to negotiate condom. Conclusion Gender-based issues and socio-cultural norms diminished individual agency of emerging adults, especially females, achieving positive sexuality. Policies that dispel socio-cultural and gendered norms in sexual relationships should be encouraged, including increased awareness on sex education to parents and children, skill acquisitions and empowerment programmes for emerging adults and capacity building of health providers to improve provision of SRH needs of emerging adults.
Accumulation of As and Pb in Vegetables Grown in Agricultural Soils Contaminated by Historical Mining in Zacatecas, Mexico
Authors: Muñoz Silvia Salas , Valdez Elvia Valdez , Castillo Jorge Armando Mauricio , Badillo Fátima Berenice Salazar , Carrillo Héctor René Vega , Salas-Luevano Miguel Angel 
Published: June 2021

Abstract
Historical mining activities are a source of environmental pollution that affects the food chain and the health of human beings. The aim of this study was assessment the accumulation of arsenic and lead in vegetables grown in agricultural soils contaminated by old mining in Zacatecas, Mexico. The concentration of arsenic and lead in agricultural soil and edible parts of carrot, garlic, and pepper was analyzed by atomic absorption spectrometry. The soil-vegetable bioconcentration factor and pollution load index were determined. The pH values of the farmland were alkaline. The concentration of arsenic in agricultural soil exceeds the permissible limit for arsenic of Mexican standards and international representing health risks. The lead content in most soil samples they were low. The arsenic and lead content in edible parts of species vegetable exceeded the national standard from various countries and the values established by the Codex Alimentarius (FAO-WHO). The highest arsenic concentration was found both in Capsicum annum and Allium sativum. The highest concentration of Pb was in pepper fruits. Among vegetable the high BCF value was for arsenic, ranging from 2.33 to 0.64, and the average for all vegetable samples was 1.01. The pollution index indicates that arsenic is the dominant pollutant accumulated in soil and vegetables grown in agricultural soils. According to the findings, the state and national agricultural and health authorities should not recommend the cultivation of vegetables in agricultural soil located in this area of historical mining activities. Likewise, preventive measures must be taken on the consumption of contaminated vegetables and certifying their safety.
Change of Intestinal Microbiota in Mice Model of Bronchopulmonary Dysplasia
Authors: Fan Tianqun , Lu Ling , Jin Rong , Sui Aihua , Guan Renzheng , Cui Fengjing , Qu Zhenghai , Liu Dongyun 
Published: June 2021

Abstract
Background: Gut microbiota has been proposed to be related to the pathogenesis of pulmonary diseases such as asthma and lung cancer, according to the gut-lung axis. However, little is known about the relationship between broncho-pulmonary dysplasia (BPD) and gut microbiota. This study was designed to investigate the changes of gut microbiota in neonatal mice with BPD. Methods: BPD model was induced through exposure to high concentration of oxygen. HE staining was utilized to determine the modeling efficiency. Stool samples were collected from the distal colon for the sequencing of V3-V4 regions of 16S rRNA, in order to analyze the gut microbiota diversity.Results: BPD models were established in this study. Alpha diversity indicated that there were no statistical differences in the abundance of gut microbiota between model group and control group. On day 14, there were statistical differences in the genetic diversity between two groups (p<0.05). Beta diversity analysis showed that there were statistical differences in the gut microbiota on day 14 (R=0.368, p=0.021). Line discriminant analysis (LDA) showed that there were 22 markers with statistical differences on day 14 (p<0.05), while those on day 7 and 21 were 3 and 4, respectively. Functional prediction analysis showed that the top 3 metabolic pathways were signal transduction (PFDR=0.037), glycan biosynthesis and metabolism (PFDR=0.032), and metabolism of terpenoids and polyketides (PFDR=0.049). Conclusions: BPD mice showed disorder of gut microbiota, which may involve with specific metabolic pathways in the early stage. In the presence of intestinal maturity in mice, the differences of the gut microbiota between the two groups would gradually disappear.
Precise crystal regulation and harvest by constructing confined flexible droplet crystallizer on 3D-printed sessile platform
Authors: Yuan Zhijie , Jiang Xiaobin , Niu Yuchao , Wu Mengyuan , Meng Yingshuang , Li Zhengtao , Ruan Xuehua , Li Xiangcun , Xiao Wu , Wu Xuemei , He Gaohong 
Published: June 2021

Abstract
Precise regulation of the mass-heat-momentum transfer carried great implications to the crystallization behavior in microscale droplet, which is one of the core concerns in crystal engineering. Herein, a confined flexible droplet crystallizer (CFDC) was facilely constructed on designed 3D-printed, matrix-type regular sessile platforms. Owing to the flexible morphology of CFDC, the synergized micro-flows generated by the integration of capillary flow and Marangoni flow in CFDC could be precisely controlled, which was validated from both experimental and simulative aspects. Standard cubic crystal was manufactured at the sessile platform center after evaporating an optimized CFDC (with 120° featured angle), where the synergized micro-flows created the perfect flow zone to balance the mass transfer and particle location. In addition, larger standard cubic crystal could be obtained via simply scale-up the platform (16 times) or supplementary feeding (secondary to forth feeding), manifesting great potential for high-quality crystal parallel preparation and harvest.