bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caregiver responsiveness as a mechanism to improve social communication in toddlers: Secondary analysis of a randomized controlled trial
Authors: Davis Paige Huguely , Elsayed Heba , Crais Elizabeth R. , Watson Linda R. , Grzadzinski Rebecca 
Published: November 2021

AbstractEarly intensive behavioral interventions (EIBI) for children at elevated likelihood for a later diagnosis of autism spectrum disorder (EL‐ASD), are often delivered through parent‐mediated models. An area of current exploration is whether changes in caregiver behaviors are a mechanism through which to improve and track child behaviors in these interventions. Toddlers and their caregivers participated in an intervention trial (randomized controlled trial) and were randomized to either a parent‐mediated intervention (adapted responsive teaching; ART) or a control condition (referral to early intervention and monitoring; REIM). Changes in toddler social communication (SC) behaviors and characteristics of caregiver responsiveness (CR) were quantified over 8 months. Analyses were conducted to assess whether changes in CR mediated the relation between group (ART vs. REIM) and changes in child SC. Results of the current study indicated that caregivers who participated in a parent‐mediated intervention improved in three domains of CR (contingent verbal sensitivity, responsivity, affect). CR was also found to be a mechanism through which children's SC skills improved. This work provides evidence that qualities of CR serve as mechanisms through which to improve and monitor child behaviors over the course of EIBIs. These results may lead to novel intervention targets, methods for tracking change, and tailored treatment planning for toddlers with EL‐ASD. The data used in this study comes from a clinical trial that was prospectively registered with the Registry of Efficacy and Effectiveness Studies (Registry ID: 316.1v1).Lay SummaryInterventions for toddlers with high likelihood for a later diagnosis of autism often include the caregiver as an active participant in the intervention. In this study, we aimed to understand qualities of caregiver responsiveness (CR) that facilitate improvements in child behaviors during intervention. Results show that increasing verbal CR and affect are ways to improve child social skills over the course of intervention.
Economic feasibility of forest biomass feedstock supply chains: clean and dirty chips for bioenergy applications
Authors: Ha HakSoo , Brown Tristan R. , Quinn Ryan J. , Volk Timothy A. , Malmsheimer Robert W. , Fortier Marie‐Odile P. , Frank Jenny R. , Bick Steven 
Published: November 2021

AbstractThere is a lack of economic feasibility analyses on the harvesting of forest biomass to supply low‐carbon bioenergy feedstocks using actual data on the mixed product harvest in the hardwood region of the northeast USA. This study is a techno‐economic analysis of three different scenarios (clean chips, dirty chips, or pulpwood) based on data collected from whole‐tree harvesting systems over 6 years. Each scenario had two different cases: one with costs and revenues allocated by mass (allocated system), and the other without allocation (whole system). The six cases of three scenarios tested resulted in a wide range of positive net present values (NPVs) from $1 713 000 to $819 in US dollars. Clean chip production generated substantial NPVs and dirty chips generated marginal NPVs. The minimum selling prices (MSPs) of clean chips from two cases were similar, $45.92 and $45.55 per green metric ton (Mg), with maximum hauling distances (MHDs) of 247 and 250 km (km). The MSPs for dirty chips from four cases ranged from $34.38 to $37.47 per Mg with the range of MHDs from 184 to 351 km. MSP and sensitivity analyses suggest that the selling prices and harvesting production levels of clean chips and dirty chips, and purchase prices of forestry logging equipment are the key factors that most influence the profitability of the regional forest biomass feedstock supply chain. © 2021 Society of Chemical Industry and John Wiley & Sons, Ltd
Demonstration of a negative reinforcement preference assessment to determine aversiveness of types of social interaction
Authors: Slocum Sarah K. , Scheithauer Mindy , Muething Colin 
Published: November 2021

AbstractPrior researchers have validated the use of a latency assessment to create a hierarchy of demand aversiveness. Demand latency assessments help to identify high‐aversive demands for use in functional analyses and/or treatment. The current study used the same approach to evaluate aversiveness of social interaction among four individuals who engaged in target behavior maintained by social avoidance. We obtained clear hierarchies in social interaction aversiveness across all participants. For one participant, we also used the social avoidance latency assessment to demonstrate an intervention approach using gradual fading of less‐ to more‐aversive forms of social interactions. These results indicate latency assessments may be applicable to generate hierarchies of aversive situations that may evoke target behavior maintained by social negative reinforcement other than escape from demands, leading to several clinical implications, and future research directions.
Harnessing digitalization for sustainable development: Understanding how interactions on sustainability‐oriented digital platforms manage tensions and paradoxes
Authors: Hellemans Ilse , Porter Amanda J. , Diriker Damla 
Published: November 2021

AbstractIn the digital age, interactions among heterogenous actors are increasingly mediated by digital platforms. While sustainability‐oriented digital platforms (SODPs) have the potential to accelerate sustainability through increased connectivity, knowledge sharing, and co‐creation, they also have a dark side, leading to unexpected tensions and paradoxical effects that may risk the creation of value for societal actors. Understanding how digital platforms can be designed to stimulate fruitful interactions among participants without succumbing to their paradoxical effects is still an unresolved puzzle. In this paper, we examine how the bright sides of SODPs can be brought to light while reducing their associated tensions and paradoxes through a qualitative study of micro‐level knowledge integration interactions on an open platform to tackle food waste. Our analysis identified 11 distinct mechanisms and 3 main interactional patterns through which participants framed the scale of the sustainability problem, mobilized resources for their solutions, and generated breadth and diversity of knowledge on the platform to tackle the problem of food waste. Our study contributes to research on SOPDs by showing how participants can take on a “distributed brokering” role through their interactions on the platform. We also provide implications to policy‐oriented practitioners regarding platform design choices to help manage known paradoxes and tensions of SOPDs.
Electroencephalographic and morphometric abnormalities in psychopath offenders
Authors: Calzada‐Reyes Ana , Alvarez‐Amador Alfredo , Galán‐Garcia Lidice , Valdés‐Sosa Mitchell 
Published: November 2021

AbstractThe main goals of the present study were to replicate and extend current knowledge related to paralimbic dysfunctions associated with psychopathy. The research evaluated the quantitative electroencephalography, current density (CD) source and synchronization likelihood analysis during the rest condition and structural magnetic resonance imaging images to compare volumetric and cortical thickness, in inmates recruited from two prisons located in Havana City. The Psychopathy Checklist‐Revised (PCL‐R) was used as a quantitative measure of psychopathy. This study showed most beta energy and less alpha activity in male psychopath offenders. Low‐resolution electromagnetic tomography signified an increase of beta activity in psychopath offender groups within paralimbic regions. The superior temporal gyrus volume was associated with the F1 factor while the fusiform, anterior cingulate and associative occipital areas were primarily associated with the F2 factor of PCL‐R scale. Cortical thickness in the left dorsal anterior cingulate cortex and the temporal pole was negatively associated with PCL‐R total score.
Dcf1 induces glioblastoma cells apoptosis by blocking autophagy
Authors: Luo Guanghong , Feng Ruili , Li Wengang , Chen Yanlu , Sun Yangyang , Ma Junfeng , Duo Yanhong , Wen Tieqiao 
Published: November 2021

AbstractBackgroundDcf1 has been demonstrated to play vital roles in many CNS diseases, it also has a destructive role on cell mitochondria in glioma cells and promotes the autophagy. Hitherto, it is unclear whether the viability of glioblastoma cells is affected by Dcf1, in particular Dcf1 possesses broad localization on different organelles, and the organelles interaction frequently implicated in cancer cells survival.MethodsSurgically excised WHO grade IV human glioblastoma tissues were collected and cells isolated for culturing. RT‐PCR and DNA sequencing assay to estimate the abundance and mutation of Dcf1. iTRAQ sequencing and bioinformatic analysis were performed. Subsequently, immunoprecipitation assay to evaluate the degradation of HistoneH2A isomers by UBA52 ubiquitylation. Transmission electron microscopy (TEM) was applied to observe the structure change of mitochondria and autophagosome. Organelle isolated assay to determine the distribution of protein. Cell cycle and apoptosis were evaluated by flow cytometric assays.ResultsDcf1 was downregulated in WHO grade IV tumor without mutation, and overexpression of Dcf1 was found to significantly regulate glioblastoma cells. One hundred and seventy‐six differentially expressed proteins were identified by iTRAQ sequencing. Furthermore, we confirmed that overexpression of Dcf1 destabilized the structure of the nucleosome via UBA52 ubiquitination to downregulate HistoneH2A.X but not macroH2A or HistoneH2A.Z, decreased the mitochondrial DNA copy number and inhibited the mitochondrial biogenesis, thus causing mitochondrial destruction and dysfunction in order to supply cellular energy and induce mitophagy preferentially but not apoptosis. Dcf1 also has disrupted the integrity of lysosomes to block autolysosome degradation and autophagy and to increase the release of Cathepsin B and D from lysosomes into cytosol. These proteins cleaved and activated BID to induce glioblastoma cells apoptosis.ConclusionsIn this study, we demonstrated that unmutated Dcf1 expression is negatively related to the malignancy of glioblastoma, Dcf1 overexpression causes nucleosomes destabilization, mitochondria destruction and dysfunction to induce mitophagy preferentially, and block autophagy by impairing lysosomes to induce apoptosis in glioblastoma.
Anti‐HIV Compounds from the Deep‐Sea‐Derived Fungus Chaetomium globosum
Authors: Hu Hong‐Qiang , Li Yan‐Hui , Fan Zuo‐Wang , Yan Wei‐Li , He Zhi‐Hui , Zhong Tian‐Hua , Gai Ying‐Bao , Yang Xian‐Wen 
Published: November 2021

AbstractChemical investigation on the deep‐sea‐derived fungus Chaetomium globosum led to the isolation of nine compounds. By extensive analyses of the 1D and 2D NMR as well as HR‐ESI‐MS spectra, their structures were elucidated as xylariol A (1), 1,3‐dihydro‐4,5,6‐trihydroxy‐7‐methylisobenzofuran (2), epicoccone B (3), epicoccolide B (4), chaetoglobosin G (5), chaetoglobosin Fex (6), cochliodone A (7), cochliodone B (8), and chaetoviridin A (9), assorting as four phenolics (1–4), two cytochalosans (5–6), and three azaplilones (7–9). Compounds 1–3 were firstly reported from C. globosum. Under the concentrations of 20 μg/mL, 1, 2, and 3 exhibited potent in vitro anti‐HIV activity with the inhibition rates of 70 %, 75 %, and 88 %, respectively.
A simple technique for suspension and stabilization of retrieval bag and adnexa by anchoring to the abdominal wall
Authors: Chatzipapas Ioannis , Kathopoulis Nikolaos , Kypriotis Konstantinos , Samartzis Konstantinos , Siemou Panagiota , Protopapas Athanasios 
Published: November 2021

AbstractWe describe a useful technique, in laparoscopic cystectomy in‐a‐bag, for suspension and stabilization of endobag and adnexa using temporary sutures. It intends to create an isolated field to avoid spillage of the cyst content into the abdomen in case of rupture, thereby allowing the safe laparoscopic removal of ovarian masses.
Virtual federal work‐study and student career development
Authors: Akos Patrick , Leonard A. Joshua , Hutson Bryant 
Published: November 2021

AbstractCollege students participate in work for a variety of reasons, and evidence suggests multiple career development benefits from the experience. The coronavirus disease (COVID) pandemic has transformed many of these work opportunities, including the Federal Work‐Study (FWS) program. Pilot data from one university in the Southeast suggests comparable career development outcomes between in‐person and virtual work‐study placements. We consider these data in the context of a necessary and possible transformed work landscape.
A Simple Approach towards Highly Dense Graphene Films for High Volumetric Performance Supercapacitors
Authors: Zhao Xin , Huang Cong , Tang Qunli , Hao Yisu , Zhang Yan , Hu Aiping , Chen Xiaohua 
Published: November 2021

AbstractAn interface self‐assembly followed by hydrothermal reduction method are proposed to obtain a tannic acid (TA)‐modified reduced graphene oxide composite film (|TA/RGO|). This unique method endows |TA/RGO| with several advantages: (1) TA is adopted as a redox‐active spacer between adjacent interlayers for enlarging the ion‐accessible area and contributing to pseudocapacitance; (2) due to the intensive pressure exerted by the sandwich‐like device during the hydrothermal reduction process, appropriate expansion and a relatively flat layered structure are achieved which will facilitate the ion transport. As a result, the |TA/RGO| film shows an ultrahigh volumetric performance of 701 F cm−3 with a high density of 1.91 g cm−3 using a three‐electrode system. When assembled into a symmetric supercapacitor, |TA/RGO| film delivers a high volumetric capacitance of 244.8 F cm−3 and a high capacitance retention of 100 % after 5000 cycles at the current density of 2 A g−1, showing a great potential for large‐scale application.
An integrative model of corporate mindfulness: A systematic literature review
Authors: Bayle‐Cordier Julie , Rouvelin Paul , Savoli Azadeh , Vieira‐Da‐Cunha Joao 
Published: November 2021

AbstractThe exponential increase of research on corporate mindfulness in recent years is representative of growing global interest for this topic. However, past research is often presented as conflicting and contradictory. In this paper, we develop an integrative model of corporate mindfulness that establishes links between different streams of research on mindfulness while preserving their differences. To this end, we conducted a systematic literature review of research on corporate mindfulness in management journals published between 1999 and January 2020 in EBSCO Business Source Premier. A final list of 157 articles was analyzed for this review. Results reveal four types of links at the construct level among studies that are part of the different approaches to corporate mindfulness.
Conjugated Polymers for Combatting Antimicrobial Resistance
Authors: Wang Zijuan , Geng Hao , Nie Chenyao , Xing Chengfen 
Published: November 2021

Comprehensive SummaryAntimicrobial resistance (AMR) is one of the major challenges in pathogenic infections, which endangers human health and brings devastating public health threats. Therefore, developing new materials to reduce the over‐reliance on antibiotics or to replace antibiotics is in great need to solve this problem. Conjugated polymers (CPs) with excellent light‐harvesting properties and good biocompatibility are ideal candidate materials for combatting AMR through photodynamic antimicrobial therapy (PACT) by sensitizing oxygen and photothermal therapy (PTT) by light to heat conversion. Significant works of CPs‐based antimicrobial approaches have been reported in recent years. Herein, we summarize the types of CPs‐based antimicrobial materials, illustrate their antimicrobial mechanisms, and discuss their applications in combating AMR mainly by PACT or antimicrobial PTT. In addition, we proposed some other antimicrobial treatment strategies based on CPs, hoping to provide inspiring insight for overcoming AMR.
Thickness Dependence of Doping Level in Conducting Polymer Films: the Optical Contrast Optimization in Electrochromism as a Case Study
Authors: Wang Jianqiao , Zhang Huanhuan , Ma Yuguang 
Published: November 2021

Comprehensive SummaryDoping plays an essential role in the properties of conducting polymers. Film thickness not only has a direct influence on their photoelectric properties, but also affects the doping ability, which may lead to the decline of capacitance and electrochromic properties caused by incomplete doping. Therefore, it is essential to study the quantitative relationship between doping level and film thickness in application. Herein, empirical formula between doping level and thickness was obtained by studying the spectroelectrochemistry behaviors of two different electrochromic materials, poly(N,N'‐bis(3,5‐(2‐thienyl)‐phenyl)‐1,6,7,12‐tetrachloroperylene‐3,4,9,10‐perylenetetracarboxylic diimide) (poly(Th‐Cl‐PBI)) and poly(3,4‐ethylenedioxythiophene) (PEDOT). The doping level is verified to be correlated to the reciprocal of the 3rd power of film thickness. Experimental results fit these formulas very well, giving correlation coefficient R2 higher than 0.99. The optical contrast prediction of these two electrochromic materials is also used to verify this relationship formula. For the first time, we quantitatively connect these two important parameters of conducting polymers, doping level and thickness.
Active matrix metalloproteinase‐8: A potential biomarker of oral systemic link
Authors: Umeizudike Kehinde , Räisänen Ismo , Gupta Shipra , Nwhator Solomon , Grigoriadis Andreas , Sakellari Dimitra , Sorsa Timo 
Published: November 2021

AbstractObjectivesThis mini review aims to address some possible gaps in periodontal diagnosis in clinical studies particularly involving the oral‐systemic connection with a view to minimize such gaps, and thus improve patient treatment experiences and outcomes.MethodsThe conventional assessment of periodontitis has traditionally been by clinical and radiographic oral parameters. We reviewed numerous studies published mainly within the past decade, to affirm the oral‐systemic link, the contribution of periodontitis to the inflammatory burden in various systemic diseases and conditions, and the potential role of active matrix metalloproteinase‐8 (aMMP‐8).ResultsWhile it is established that periodontal pathogens in dental plaque biofilm are the primary initiating agents in periodontitis, it has become clear from the appraisal of recent studies that the host inflammation, including biomarkers such as aMMP‐8 play a major role, being the driving underlying pathological mechanism in both periodontitis and systemic diseases.ConclusionsThe apparent limitations of conventional diagnostic tools have led researchers to seek alternative methods of evaluation such as the quantification of biomarkers including aMMP‐8, which can be a bridge between oral/periodontal and systemic diseases; aMMP‐8 can form a mouth‐body connection.
Association between type 2 diabetes and skeletal muscle quality assessed by abdominal computed tomography scan
Authors: Kim Eun Hee , Kim Hong‐Kyu , Lee Min Jung , Bae Sung‐Jin , Kim Kyung Won , Choe Jaewon 
Published: November 2021

AbstractAimTo examine the association between type 2 diabetes and the amount and quality of trunk muscle as assessed by computed tomography (CT) scan.Materials and methodsA total of 20,986 subjects (13,007 men and 7979 women) who underwent abdominal CT scan as part of a routine health check‐up were included. The total abdominal muscle area (TAMA) measured at the third lumbar vertebrae was classified into skeletal muscle area (SMA), and intermuscular adipose tissue area. SMA was divided into good quality muscles (normal attenuation muscle area [NAMA]) and poor quality muscles (low attenuation muscle area). NAMA/TAMA index was calculated.ResultsSubjects with type 2 diabetes had higher values of TAMA and SMA but significantly lower values of NAMA and NAMA/TAMA index. Compared with those in the lowest quartile of NAMA/TAMA index, subjects in the highest quartile had metabolically favourable laboratory findings, a lower prevalence of type 2 diabetes (Q1 vs. Q4: 19.3% vs. 9.5% in men, 12.3% vs. 3.0% in women) and inverse association with type 2 diabetes (odds ratio for Q2, Q3, and Q4: 0.87, 0.78, and 0.75 in men; 0.82, 0.70, and 0.68 in women) after multivariable adjustment.ConclusionsThe amount of good quality muscle on CT scan was associated with a lower prevalence of type 2 diabetes.
Increased self‐reported delay of gratification in acutely underweight, but not remitted anorexia nervosa
Authors: Weinert Tomas , King Joseph A. , Böldt Luisa , Gronow Franziska , Roessner Veit , Ehrlich Stefan 
Published: November 2021

AbstractObjectiveLaboratory experiments using delay discounting tasks have delivered some evidence of an increased capacity to delay reward in anorexia nervosa (AN). Overall, however, findings have been inconclusive and no comprehensive studies of self‐reported tendency to forgo immediate gratification in favor of long‐term rewards exist in AN.MethodA total of 71 acutely underweight female inpatients with AN (acAN); 52 women long‐term weight‐recovered from AN (recAN); and 120 healthy control women completed the Delaying Gratification Inventory (DGI). Fifty‐two acAN were reassessed after short‐term weight rehabilitation. Separate cross‐sectional and longitudinal group comparisons tested for differences in DGI subscales (food, physical pleasure, social interaction, money, and achievement) and total scores.ResultsDGI scores were elevated in acAN even after removing food‐related items and accounting for comorbid symptoms. DGI scores remained relatively elevated following short‐term weight rehabilitation, but no differences were evident between recAN and HC.DiscussionThis study delivers self‐report evidence supporting the notion of an increased propensity to delay gratification in individuals acutely ill with AN which does not appear to change with partial weight restoration alone. A reduction in the tendency to delay reward may thus be an important cognitive correlate of long‐term recovery in AN.
Camouflage versus running performance as strategies against predation in a lizard inhabiting different habitats
Authors: Wan Lixia , Liu Zhenxia , Wang Tao , Yang Minglu , Li Jiasheng , Sun Hui , Niu Chenkai , Zhao Wei , Jin Yuanting 
Published: November 2021

AbstractRunning speed and camouflage are associated with the foraging and anti‐predator abilities of animals. The toad‐headed lizard, Phrynocephalus versicolor, has evolved a darker dorsal color in melanistic habitats and maintained a lighter color in adjacent, non‐melanistic habitats. We test the hypothesis that lizards have weaker running speed on well‐matching backgrounds than on less matching backgrounds. We used lizard models to compare the predation pressure, while the running speed of dark and light lizards were compared in field tunnels using a video recording method. Our results indicated that both the dark lizards in melanistic Heishankou (HSK) and the light lizards in non‐melanistic Guazhou (GZ) face lower predation pressure than potential color‐background unmatched lizards. The light lizards have a potentially higher running speed than darker lizards in melanistic habitats, which implies that substrate color matching populations with benefits of camouflage might have lower anti‐predation pressure, and the costs of investment in melanin production may reduce running capacity.