bluuebunny/crossref_metadata_2025_split huggingface dataset:
Henry Savile and the Elizabethan Court
Authors: Gajda Alexandra 
Published: March 2021

Abstract
This essay examines Henry Savile’s relationship with the Elizabethan and Jacobean court and the political culture of the period in which he lived. Particular attention is paid to the controversies surrounding Savile’s alleged connection to Robert Devereux, 2nd earl of Essex and the court politics of the 1590s, and variant interpretations scholars have made of the political significance of his historical scholarship. Savile’s Elizabethan literary remains demonstrate his persistent interest in the association between militarism and the arts of civil government, and the frequently problematic relationship of virtuous soldiers and statesmen to princely rulers. These concerns were shared by leading Elizabethan soldiers and statesmen, from the earl of Leicester, William Cecil, Lord Burghley, to the earl of Essex, and may have influenced the latter’s growing alienation from queen and court in the late 1590s. A broader comparison of Savile’s career with those of contemporary Merton scholars, however, confirms that he rejected the public careers pursued by other friends and colleagues. Savile’s political connections seem to have served his scholarly ambitions rather than the other way around, and after the rebellion of the earl of Essex he seems to have retreated from life at court.
The Printer’s Copy of Henry Savile’s Tacitus
Authors: Philo John-Mark 
Published: March 2021

Abstract
In 1591, Henry Savile completed his celebrated translation of Tacitus, dedicating his efforts to the queen. Remarkably, the printer’s copy of Savile’s translation has survived, now preserved at the Bodleian Library, Oxford (Bodl. ms Eng. hist. d. 240). Replete with handwritten notes by both Henry Savile and his younger brother, Thomas, the manuscript offers a fascinating insight into the final stages of the translation. From instructions for the printer to last-minute changes to the text, the manuscript shines new light on print culture in the final years of the sixteenth century. This article establishes the manuscript’s provenance, tracing its journey from Savile’s study to Methley Manor, Yorkshire, and finally to the Bodleian Library. It also considers the evidence provided by the manuscript of collaboration between Henry and Thomas Savile as they undertook this extraordinary translation-cum-commentary. Finally, by comparing the text of the translation as it appears in the printer’s copy with that of the published version, the article explores what this manuscript reveals about Savile’s methods of, and approach to, translation.
Politics, Patronage and Medieval Scholarship: Henry Savile’s Rerum Anglicarum scriptores post Bedam (1596) in Context
Authors: Roebuck Thomas 
Published: March 2021

Abstract
Henry Savile’s Rerum Anglicarum scriptores (1596), his collection of writings of medieval historians, was essential reading for Britain’s antiquaries for generations. However, it has not generally figured largely in histories of British antiquarianism and its publication has seemed a puzzling episode in Savile’s scholarly career. This article draws on newly-discovered or redated print and manuscript evidence to illuminate the nexus of politics and patronage from which the book emerged. Exploring Savile’s place within British antiquarianism, his practice as an editor of medieval manuscripts, and the volume’s publication in Frankfurt, the essay argues that Savile’s Scriptores constitutes a significant departure from earlier sixteenth-century traditions of medieval textual editing.
Motivations and Constraints of Collaborative Consumption, Testing the Mediating Role of Attitude and nature of Trust
Authors: Bhalla Saubhagya 
Published: March 2021

Purpose: The current study aims to analyse the relationship among motivation, constraints and intention to participate in collaborative consumption, with attitude acting as a mediating variable. The study also aims to unravel the role of trust dimension within the context of collaborative consumption. Research methodology: The descriptive research design is applied for the present study. Random sampling techniques including area sampling is applied. Data analysis: Linear regression, approach is applied to analyse the data. Hierarchical multiple regression is used to assess the effects of a moderating variable. Findings: Economic concerns are less important as compared to environmental concerns. Materialistic traits of consumers prevent them from participating in collaborative consumption, and perceived risk also acts as a barrier. Attitude has a very important role in collaborative consumption. Institution-based trust is an impactful independent variable but shows no moderating impact. Implications: Marketers can increase the economic benefits of consumers through discount and loyalty cards. Because environmental concerns have a huge impact on attitude and intention, marketers must emphasize on the sustainability aspect of their offerings. For millennials, the most valuable things in life are the lived experiences instead of possessions (Morgan, 2019). Therefore, marketers must leverage on consumer experiences rather than goods. Most importantly, marketers need to focus on the attitude factor. Moreover, the companies must emphasize on the security of the Internet and must explicitly mention the structural and technological safeguards for promoting trust among consumers. The digital platforms can incorporate various measures that can help in promoting privacy and security of the consumers. Areas such as authentication, encryption and integrity need to be given more attention. Originality/value: The study has filled the gap in the existing literature by examining the mediating role of attitude on the relationship of motivations and constraints and behavioural intentions. The study has also contributed by exploring institution-based trust in collaborative consumption.
A representation learning model based on variational inference and graph autoencoder for predicting lncRNA-disease associations
Authors: Shi Zhuangwei , Zhang Han , Jin Chen , Quan Xiongwen , Yin Yanbin 
Published: March 2021

AbstractBackgroundNumerous studies have demonstrated that long non-coding RNAs are related to plenty of human diseases. Therefore, it is crucial to predict potential lncRNA-disease associations for disease prognosis, diagnosis and therapy. Dozens of machine learning and deep learning algorithms have been adopted to this problem, yet it is still challenging to learn efficient low-dimensional representations from high-dimensional features of lncRNAs and diseases to predict unknown lncRNA-disease associations accurately.ResultsWe proposed an end-to-end model, VGAELDA, which integrates variational inference and graph autoencoders for lncRNA-disease associations prediction. VGAELDA contains two kinds of graph autoencoders. Variational graph autoencoders (VGAE) infer representations from features of lncRNAs and diseases respectively, while graph autoencoders propagate labels via known lncRNA-disease associations. These two kinds of autoencoders are trained alternately by adopting variational expectation maximization algorithm. The integration of both the VGAE for graph representation learning, and the alternate training via variational inference, strengthens the capability of VGAELDA to capture efficient low-dimensional representations from high-dimensional features, and hence promotes the robustness and preciseness for predicting unknown lncRNA-disease associations. Further analysis illuminates that the designed co-training framework of lncRNA and disease for VGAELDA solves a geometric matrix completion problem for capturing efficient low-dimensional representations via a deep learning approach.ConclusionCross validations and numerical experiments illustrate that VGAELDA outperforms the current state-of-the-art methods in lncRNA-disease association prediction. Case studies indicate that VGAELDA is capable of detecting potential lncRNA-disease associations. The source code and data are available athttps://github.com/zhanglabNKU/VGAELDA.
Association of circulating adipsin with nonalcoholic fatty liver disease in obese adults: a cross-sectional study
Authors: Zhang Jinhua , Li Kangli , Pan Lingling , Teng Fei , Zhang Peizhen , Lin Bingquan , Yuan Youwen , Wei Xueyun , Li Wenyuan , Zhang Huijie 
Published: March 2021

Abstract
Background
As a secreted adipokine, adipsin has been recently shown to play a pivotal role in metabolic disorders. However, information regarding the association of circulating adipsin with non-alcoholic fatty liver disease (NAFLD) in humans is scant.

Methods
We recruited 1163 obese adult subjects with waist circumference at least 90 cm in men and 80 cm in women from the community. Circulating adipsin levels were measured by enzyme-linked immunosorbent assay.

Results
Circulating adipsin levels of NAFLD subjects was decreased compared to those in non-NAFLD (p < 0.05). The prevalence of NAFLD with lower levels of serum adipsin was significantly higher than those with higher values (57.6% vs. 50.9%, p < 0.05). Circulating adipsin levels were significantly associated with decreasing levels of fasting glucose and postprandial glucose (both p < 0.001 for interaction) in NAFLD subjects but not in non-NAFLD subjects. The risk of NAFLD was significantly decreased by 21.7% [OR (95% CI): 0.783 (0.679–0.902), p < 0.001], adjusting for age, gender, current smoking, alcohol consumption, physical activity, BMI, systolic BP, fasting glucose, total cholesterol, HDL-c, HOMA-IR, and body fat mass. Importantly, subjects in the lowest quartile of circulating adipsin were 1.88 times more likely to have NAFLD than those in the highest quartile in multivariable logistic regression analyses. However, such associations with circulating adipsin were not noted for metabolic syndrome, abnormal liver enzyme and significant liver fibrosis.

Conclusions
These results demonstrate that circulating adipsin levels in Chinese obese adults are negatively associated with risk of NAFLD, implying that serum adipsin levels may be a potential protective factor in NAFLD.
Clinical false positives resulting from recent intravenous immunoglobulin therapy: case report
Authors: Suresh Janarthanee , Kyle Barry D. 
Published: March 2021

Abstract
Background
Many clinicians are aware that certain therapies administered to their patients can have downstream consequences in the form of clinical laboratory test interferences. This is particularly true of laboratory tests that depend on, or directly involve the use of, antibody-based methodology. Intravenously-administered immunoglobulin therapy is one such treatment that can in theory directly impact the results of particular tests in the area of viral serology. This study can help serve as a reference for clinicians researching the impact of intravenously-administered immunoglobulin therapy in the context of positive results that do not reflect the clinical background of the patient.

Case presentation
We describe a case whereby an intravenously-administered immunoglobulin therapy led to a series of clinical false positives in viral serology, inconsistent with the known patient history as well as recent laboratory results. The patient presented to hospital with petechiae-type bleeding rashes and was investigated for thrombocytopenia after initial blood investigations indicated very low platelets.
Subsequent testing of the potential causes for low-platelet involved several viral serology investigations, including hepatitis, cytomegalovirus and human immunodeficiency virus. Initial testing indicated patient exhibited negative status for all viral antibodies and antigens (except immunity for hepatitis B surface antigen antibody).
As part of the thrombocytopenia treatment, intravenously-administered immunoglobulin therapy was administered, and subsequent viral serology was ordered. These investigations indicated a positive status for several hepatitis antibodies as well as cytomegalovirus.

Conclusions
This case study illustrates the potential for improper diagnosis of previous or ongoing infection status in patients administered IVIg therapy. Caution should be exercised particularly when interpreting results involving cytomegalovirus and hepatitis.
Temporal trends in pulmonary embolism prevalence in Greece during 2013–2017
Authors: Lampropoulos Ioannis C. , Raptis Dimitrios G. , Daniil Zoe , Tasoulis Sotirios K. , Plagianakos Vassilis P. , Malli Foteini , Gourgoulianis Konstantinos I. 
Published: March 2021

Abstract
Background
Pulmonary embolism (PE) epidemiological data about the disease prevalence in the general population are unclear. The present study aims to investigate the prevalence of PE in Greece and the associated temporal trends for the years 2013–2017.

Methods
Data on medical prescriptions for PE in the years 2013–2017 were provided by the Greek National Health Service Organization (EOPYY). Data on age, gender, specialty of the prescribing physician and prescription unit were provided as well.

Results
The total number of medical prescriptions for PE for the study period was 101,426. Of the total prescriptions, 51% were issued by the Public Sector and 48% by the Private Sector. In 2013 the prevalence of PE was 5.43 cases per 100,000 citizens and increased constantly until 2017 with 23.79 cases per 100,000 population. Prevalence was higher in all years studied in the age group of 70–80 years. For the year 2017, we observed 69.35 cases per 100,000 population for subjects 70–80 years, followed by the ages 80–90 (60.58/100,000) and 60–70 years (56.47 /100,000). Females displayed higher PE prevalence than males and higher increasing trend.

Conclusion
PE prevalence has an increasing trend throughout the years 2013–2017 while prevalence in females is higher than males and displays a higher increasing trend. Our results may be used to appropriately organize nationwide health care campaigns aiming at the diagnosis, treatment and prevention of PE.
Parental mental health conditions and use of healthcare services in children the first year of life– a register-based, nationwide study
Authors: Heuckendorff Signe , Johansen Martin Nygård , Johnsen Søren Paaske , Overgaard Charlotte , Fonager Kirsten 
Published: March 2021

Abstract
Background
Parental mental health conditions have been associated with increased morbidity and use of healthcare services in offspring. Existing studies have not examined different severities of parental mental health conditions, and the impact of paternal mental health has been overlooked.
We examined the association between two severities of parental mental health conditions and use of healthcare services for children during the first year of life and explored the impact of both maternal and paternal mental health conditions.

Methods
This register-based cohort study included all live-born children born in Denmark from 2000 to 2016. Information on socioeconomics, diagnoses, drug prescriptions, and healthcare contacts was extracted from nationwide public registries. Parents were grouped according to severity of mental condition based on the place of treatment of the mental health condition. Negative binominal regression analyses were performed to estimate the incidence rate ratio (IRR) of contacts to general practice (GP), out-of-hour medical service, emergency room (ER), and out- and inpatient hospital contacts during the first 12 months of the child’s life.

Results
The analyses included 964,395 children. Twenty percent of the mothers and 12 % of the fathers were identified with mental health conditions. Paternal mental health conditions were independently associated with increased risk of infant healthcare contacts (GP IRR 1.05 (CI95% 1.04–1.06) and out-of-hour IRR 1.20 (CI95% 1.18–1.22)). Risks were higher for maternal mental health conditions (GP IRR 1.18 (CI95% 1.17–1.19) and out-of-hour IRR 1.39 (CI95% 1.37–1.41)). The risks were even higher if both parents were classified with a mental health condition (GP IRR 1.25 (CI95% 1.23–1.27) and out-of-hour contacts IRR 1.49 (CI95% 1.45–1.54)), including minor mental health condition (GP IRR 1.22 (CI95% 1.21–1.24) and out-of-hour IRR 1.37 (CI95% 1.34–1.41)). This pattern was the same for all types of healthcare contacts.

Conclusions
Both maternal and paternal mental health conditions, including minor mental health conditions, were associated with increased utilization of healthcare services. Focus on both parents’ mental health conditions (even if minor) may be warranted in service planning.
Japanese health and safety information for overseas visitors: protocol for a randomized controlled trial
Authors: Nishikawa Mariko , Yamanaka Masaaki , Shibanuma Akira , Kiriya Junko , Jimba Masamine 
Published: March 2021

Abstract
Background
Before the COVID-19 pandemic occurred in January 2020, the number of overseas visitors to Japan had increased threefold over the last decade. To minimize the risk of health problems, visitors should be able to access information on the health care systems of the places they visit. Most short-term overseas visitors are young adults. Although they are not very likely to get sick from noncommunicable diseases, they are at high risk for injury and often experience stomach ailments, fever, or nausea when travelling. The objective of this study is to evaluate culturally and linguistically appropriate health information on preventive health behaviours and the health care system in Japan. We will examine the level of satisfaction of overseas visitors to Japan with health care-related educational materials using a five-minute digital game named Sa-Chan Japan.

Methods
Our study is a randomized controlled trial (RCT). We will assess both satisfaction and motivation before, during, and after the interventions and examine the changes over time. The intervention group will comprise overseas visitors who will view and answer questions in an animation named Sa-Chan Japan. The control group will comprise overseas visitors who will watch an English digital animation named Mari Info Japan. We will recruit 1002 participants through the Macromill Internet portal. We will contact overseas visitors who have either visited or wish to visit Japan from the United Kingdom, United States, and Australia. The participants will fill out a self-administered questionnaire online in the first quarter of 2021. We will determine the participants’ levels of satisfaction with the CSQ-8 (8-item Client Satisfaction Questionnaire). We will analyse the median score of the overseas visitors with both the Wilcoxon rank-sum and the Wilcoxon signed-rank tests. Our protocol of randomized controlled trials follows the SPIRIT guidelines.

Discussion
Our research will utilize unique digital education strategies in a game that promotes health and safety among overseas visitors to Japan. We believe the results of this study will be useful in overcoming the current challenges regarding pretravel health requirements for overseas visitors worldwide.

Trial registration
Version 1 of this trial was registered in the UMIN-CTR (University Hospital Medical Information Network Center Clinical Trials Registry), and the trial registration data are available on UMIN000042483, November 17, 2020.
Double rarity: malignant masquerade biliary stricture in a situs inversus totalis patient
Authors: Eitler K. , Mathe Z. , Papp V. , Zalatnai A. , Bibok A. , Deak P. A. , Kobori L. , Telkes G. 
Published: March 2021

Abstract
Background
Situs inversus totalis is a rare anatomical variation of both the thoracic and the abdominal organs. Common bile duct strictures can be caused by malignant and benign diseases as well. 7–18% of the latter ones are 'malignant masquerade’ cases, as pre-operative differentiation is difficult.

Case presentation
We present the case of a 68y male patient with known situs inversus totalis and a recent onset of obstructive jaundice caused by a malignant behaving common bile duct stricture. Technically difficult endoscopic retrograde cholangiopancreatography, brush cytology, magnetic resonance cholangiopancreatography, endoscopic ultrasound, and percutaneous transhepatic drainage with stent implantation were performed for proper diagnosis. Cholecystectomy, common bile duct resection with hilar lymphadenectomy, and hepatico-jejunostomy have been performed following multidisciplinary consultation. The final histology report did not confirm any clear malignancy, the patient is doing well.

Conclusion
In situs inversus patients, both diagnostic and therapeutic procedures can lead to various difficulties. Benign biliary strictures are frequently misdiagnosed preoperatively as cholangiocellular carcinoma. Surgery is usually unavoidable, involving a significant risk of complications. The co-existence of these two difficult diagnostic and therapeutic features made our case challenging.
The inguinal hernia management in Costa Rica according to a survey between surgeons: result comparison with 2018 International Groin Hernia Guidelines
Authors: Martínez-Hoed Jesús , Cordero-Bermúdez Katherine , García-Pastor Providencia , Pous-Serrano Salvador , Ortiz-Cubero José A. 
Published: March 2021

Abstract
Background
Inguinal hernia surgery is a frequent procedure among general surgeons in Costa Rica, but the management and technique are not uniform. The International Guideline for Groin Hernia management was published in 2018 to standardize the inguinal hernia surgery, but the diffusion of the guidelines and its adherence have been extremely varied.

Purpose
Collect and analyze the current reality regarding groin hernia management in Costa Rica. Secondly evaluate the diffusion and development comparing it to the guideline’s recommendations.

Method
Questionnaire of 42 single and multiple answer questions according to the topics of the International Guideline directed
to general surgeons. Diffusion of the inquiry through surgical and hernia association chats and email. Timeframe June–December 2019.

Results
64 surveys were collected, which is a representative number of the general surgeons national college. The most frequent procedure between these was the abdominal wall surgery. Every surgeon did more than 52 groin hernia surgeries in one year, most of them outpatients. The epidural anesthesia was used the most and Lichtenstein’s technique was the most frequently used (64%). 68% of the surgeons know how to perform a minimally invasive inguinal hernia surgery but with variable volumes. 38% of participants considered themselves experts in groin hernia management and 52% did not know the 2018 International Guideline. The recommendations of such guideline are followed only partially.

Conclusions
The 2018 Hernia Surge International Guidelines have low diffusion among Costa Rican surgeons. The laparoscopic approach is widely accepted but there are no studies to assess the results and the quality. There should be protocols and studies adapted to Costa Rica’s national situation.