bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cover, Content, and Editorial Note from Borneo J Pharm Vol. 4 No. 3 August 2021
Authors: Borneo J Pharm Chief Editor Of 
Published: September 2021

Assalamu’alaikum Wr. Wb.
Alhamdulillahirabbil ‘alamin. The next edition of Borneo Journal of Pharmacy (Borneo J Pharm), has been published in August 2021. Starting from this volume, Borneo J Pharm increases the frequency of publishing four times a year. This change aims to improve the circulation of the best articles published by Borneo J Pharm.
This edition contains ten articles consisting of Pharmacology-Toxicology, Microbiology Pharmacy, Natural Product Development, Clinical-Community Pharmacy, and Management Pharmacy. This edition includes writings from four countries including Greece, Indonesia, Saudi Arabia, and Sudan. The authors come from several institutions, including STIKES Cendekia Utama Kudus, Universitas Sari Mulia, National Agency of Drug and Food Control of Republic of Indonesia, National Agency of Drug and Food Control of Republic of Indonesia in Gorontalo, Universitas Muhammadiyah Kalimantan Timur, Balai Taman Nasional Gunung Merapi, Universitas Sembilanbelas November Kolaka, Sekolah Tinggi Ilmu Farmasi Riau, Omdurman Islamic University, University of Khartoum, King Saud University, Indonesian Institute of Sciences, Universitas Pancasila, Universitas Lambung Mangkurat, Universitas Jenderal Achmad Yani, Ibrahim Adjie Health Center, University of Crete, Aristotle University of Thessaloniki, New York College, Universitas Islam Sultan Agung, Sekolah Tinggi Ilmu Kesehatan Borneo Lestari, and Universitas Muhammadiyah Surakarta.
The editorial board would like to thank all editors and reviewers, and contributors of the scientific articles who have provided the repertoire in this issue. We hope that all parties, especially the contributors, could re-participate for publication in the next edition in November 2021.
Wassalamu’alaikum Wr. Wb.
The Determinants of Dividend Policy: A Comparison between Firms Listed on the Italian Stock Exchange and on the Warsaw Stock Exchange (2001–2014)
Authors: Chesini Giusy , Staniszewska Aleksandra 
Published: September 2021

Several theories have been documented on the relevance and irrelevance of dividend policy. Many researchers continue to come up with different findings on the relevance ofdividend policy to the value of firms. In this paper, after an analysis of the different dividend pay-outs offered by Italian and Polish firms, we aim to understand the main factors thatdetermine the dividend policies of listed companies in Italy and Poland. In order to analyse this policy, we extract data from a wide sample of firms selected from the equity markets of the Italian and Polish stock exchanges. We use descriptive statistics and statistical regressions. The analysis is developed using the Statistical Package for Social Sciences (SPSS).
The study reaches findings that are of great relevance to scholars and investors investigating dividend issues. The paper finds that there are many differences between Italian andPolish dividend policies; in particular, the dividend pay-out is mostly determined by the dividend yield and liquidity in Polish firms, while it is heavily influenced by profitabilityand leverage in Italian firms.
Relations between transport choices and active behaviour
Authors: Suchanek Michał 
Published: September 2021

Unhealthy lifestyle choices and passive behaviour are a significant problem for many developed countries. They lead to a decrease in public health in the form of diseases related to contemporary civilization, such as: cardiovascular diseases, type II diabetes and obesity. This increases the costs generated in the healthcare system. The share of costs resulting from combating these diseases increases every year.The choice of a transport mode used when commuting is often perceived as one of the factors leading to more proactive behaviour and thus decreasing the externalities not only connected directly with transport such as pollution, noise, congestion and accidents, but also those connected with public health.The paper shows the results of a study performed in Poland, which was meant to identify and measure the relations between the transport choices and other proactive choices of commuters. A logistic regression model was estimated to identify the occurrence and intensity of these relations.
The goal of the article is, therefore, to assess whether the choice of a transport mode used when commuting is connected with other types of proactive behaviour of citizens. In particular, the authorwishes to determine if people choosing a car as their mode of transport tend to be generally less active than people choosing public transport or those who commute actively.
Impact of host countries' environmental regulations along the Belt and Road Initiative on China's Outward Foreign Direct Investment
Authors: Qiu Qiang , Zhang Tongxun 
Published: September 2021

This paper makes use of the panel data of China's direct investment in 61 countries along the ‘Belt and Road' from 2006 to 2016. Using the investment gravity model, we first carry out the total data regression, then the sample data regression based on the national income, the environmental reg- ulation intensity and the district position. The study found that, as far as the overall sample is con- cerned, the national environmental regulation along the ‘Belt and Road' has a significant inhibitory effect on China's Outward Foreign Direct Investment (OFDI), and the countries along the line are grouped according to income levels. Environmental regulations vary according to the differences in national income levels: environmental regulations in high income and intermediate-high income countries have a notable negative correlation with the OFDI of China, while environmental regula- tions in low-and middle-income countries have no significant impact on China's OFDI. According to the intensity of environmental regulation, the countries along the ‘Belt and Road' are grouped. The empirical results show that China's OFDI was significantly inhibited by countries whose national environmental regulations are higher than the Environmental Performance Index (EPI), while China's OFDI was not affected by the countries whose national environmental regulations are lower than the EPI. According to the different regional groupings of the host country, it was found that the environmental regulations of European countries and West Asian countries significantly inhibited China's OFDI, while the environmental regulations of the Middle East and North Africa and East Asian countries had no significant impact on China's OFDI.
Some other important factors affecting China's OFDI should be taken into consideration, includ- ing the scale of the economy in the investment home country, the host country's economic level, strategic resources, infrastructure, government regulation, and bilateral trade tightness. Except for the government regulation level, which has an inhibitory effect on China's OFDI, the others have a strong promoting effect. This is consistent with the conclusions drawn by Qiu Qiang [2018]. The role of natural resources is not significant, indicating that China has insufficient incentives to natural resources along the ‘Belt and Road' countries.
Finally, from the perspective of the government and enterprises, policy recommendations are pro- posed relevant to China's OFDI along the ‘Belt and Road'. The government should actively collect the measurement data of the host country's environmental regulations, carry out investment grading according to the strength of the environmental regulations and formulate different investment strat- egies accordingly. Chinese companies must pay attention to technology and innovation capabilities, which is conducive to reducing the extrusion of OFDI with similar technology levels.
Użytkowanie samochodów osobowych w świetle podatków dochodowych – możliwości optymalizacji podatkowej w latach 2018–2019​​
Authors: Szlęzak-Matusewicz Joanna 
Published: September 2021

Przedmiotem rozważań w niniejszym artykule są zagadnienia odnoszące się do rozliczania w rachunku podatkowym kosztów związanych z nabyciem, użytkowaniem i zbyciem samochodów osobowych wprowadzonych do ewidencji środków trwałych oraz wartości niematerialnych i prawnych podatnika. Celem artykułu jest prezentacja możliwości optymalizacji podatkowej w tym zakresie w świetle przepisów obowiązujących do końca 2018 r. i od początku 2019 r. Przyjęta przez autorkę teza brzmi: Zmiana przepisów podatkowych w zakresie samochodów osobowych, obowiązujących od 2019 r., ograniczyła znacznie możliwości optymalizacji podatników, ale nie zlikwidowała ich całkowicie. Metodami badawczymi przyjętymi w artykule są: analiza przepisów ustawy o podatku dochodowym od osób fizycznych oraz studia przypadków.
Cortometraje animado en software 2D “Quinua del viento”
Authors: Ramos Jiménez Rosa Belén , Cabascango Tisalema Alex Xavier , Duque Vaca Miguel Ángel , Rivera Abarca Ana Lucía 
Published: September 2021

Introducción El presente estudio se centra en la producción de un cortometraje animado sobre el proceso de producción de la quinua. Hasta ahora, todos los esfuerzos se han dedicado a posicionar la quinua como un superalimento con gran potencial nutricional, sin embargo, se ha dejado a un lado su valor cultural e histórico. Objetivo Por lo cual, el objetivo principal del cortometraje es la revalorización de la quinua como grano ancestral, que pretende motivar su cultivo y consumo local desde este enfoque. Metodología En base a la metodología de Bruce Archer, que tiene tres fases; analítica, creativa, y ejecutiva, se inició recolectando información acerca del origen y producción de la quinua, mediante fichas de observación, entrevistas a expertos, productores de quinua y expertos en otras áreas. A partir de esta investigación, se desarrolló la historia “Quinua del viento”. Resultados La última fase se desarrolló, siguiendo las etapas típicas de la producción del cortometraje: pre-producción, producción, y pos-producción. Así, de la historia, se elaboró el guion y el storyboard, los cuales sirvieron como guía visual en la siguiente etapa. La segunda fase, se utilizó la técnica del Stop Motion. En esta etapa se diseñaron los personajes y ambientes, inspirados en indígenas y escenarios de la provincia de Chimborazo. Finalmente, se utilizó el Software de animación 2D “Adobe Premiere Pro” para la edición y retoque del cortometraje. Adicional a esto, se desarrolló la musicalización, el ritmo seleccionado fue el “Albazo”, por ser un género musical de la sierra ecuatoriana.
The Negative Impacts of Acromegaly on Bone Microstructure Not Fully Reversible
Authors: Duan Lian , Yang Shengmin , Wang Lin Jie , Zhang Yuelun , Li Ran , Yang Hongbo , Zhao Yuxing , Du Hanze , Zhai Xiao , Gong Fengying , Pan Hui , Zhu Huijuan , Xia Weibo 
Published: September 2021

PurposeThis study aimed to evaluate the bone turnover markers and bone microarchitecture parameters derived from high-resolution peripheral quantitative computed tomography (HR-pQCT) in active and controlled acromegaly patients.MethodsThis cross-sectional study involved 55 acromegaly patients from a tertiary hospital (23 males and 32 females, aged 45.0 ± 11.6 years). Firstly, growth hormone (GH), insulin-like growth factor-1 (IGF-1), and markers for bone turnover were assessed. Next, we derived peripheral bone microstructure parameters and volumetric bone mineral density (vBMD) through HR-pQCT. These parameters were compared between acromegaly patients and 110 healthy controls, as well as between 27 active and 28 controlled acromegaly patients. Moreover, the relationship between GH/IGF-1 and bone microstructure parameters was analyzed through multiple linear regression.ResultsAs compared with healthy controls, acromegaly patients exhibited elevated cortical vBMD, reduced trabecular vBMD, and increased trabecular inhomogeneity in the distal radius and tibia. While controlled acromegaly patients had slower bone turnover, they did not necessarily have better bone microstructure relative to active patients in intergroup comparison. Nevertheless, multiple regression indicated that higher IGF-1 was associated with lower tibial stiffness and failure load. Additionally, males with higher IGF-1 typically had larger trabecular separation, lower trabecular number, and larger cortical pores in the radius. Moreover, patients with elevated GH typically had more porous cortical bone in the radius and fewer trabeculae in the tibia. However, the compromised bone strength in active patients was partially compensated by increased bone thickness. Furthermore, no significant linkage was observed between elevated GH/IGF-1 and the most important HR-pQCT parameters such as trabecular volumetric bone density.ConclusionAcromegaly adversely affected bone quality, even in controlled patients. As the deterioration in bone microstructure due to prolonged GH/IGF-1 exposure was not fully reversible, clinicians should be aware of the bone fragility of acromegaly patients even after they had achieved biochemical remission.
Gestational Hormone Concentrations Are Associated With Timing of Delivery in a Fetal Sex-Dependent Manner
Authors: Cathey Amber L. , Watkins Deborah J. , Rosario Zaira Y. , Vega Carmen M. Vélez , Mukherjee Bhramar , O’Neill Marie S. , Loch-Caruso Rita , Alshawabkeh Akram N. , Cordero José F. , Meeker John D. 
Published: September 2021

BackgroundEarly delivery remains a significant public health problem that has long-lasting impacts on mother and child. Understanding biological mechanisms underlying timing of labor, including endocrine disruption, can inform prevention efforts.MethodsGestational hormones were measured among 976 women in PROTECT, a longitudinal birth cohort in Puerto Rico. We evaluated associations between hormone concentrations at 18 and 26 weeks gestation and gestational age at birth, while assessing effect modification by fetal sex. Exploratory analyses assessed binary outcomes of overall preterm birth (PTB, &lt;37 weeks gestation) and the spontaneous PTB subtype, defined as preterm premature rupture of membranes, spontaneous preterm labor, or both. Multivariable logistic and linear regressions were fit using visit-specific hormone concentrations, and fetal sex-specific effects were estimated using interaction terms. Main outcome models were adjusted for maternal age, education, marital status, alcohol consumption, environmental tobacco smoke exposure, and pre-pregnancy body mass index (BMI). Exploratory models adjusted for maternal age and education.ResultsWe observed reduced gestational age at birth with higher circulating CRH (β: -2.73 days, 95% CI: -4.97, -0.42), progesterone (β: -4.90 days, 95% CI: -7.07, -2.73), and fT4 concentrations (β: -2.73 days, 95% CI: -4.76, -0.70) at 18 weeks specifically among male fetuses. Greater odds of overall and spontaneous PTB were observed among males with higher CRH, estriol, progesterone, total triiodothyronine (T3), and free thyroxine (fT4) concentrations. Greater odds of PTB among females was observed with higher testosterone concentrations.ConclusionsVarious associations between hormones and timing of delivery were modified by fetal sex and timing of hormone measurement. Future studies are needed to understand differential mechanisms involved with timing of labor between fetal sexes.
Could β-Lactam Antibiotics Block Humoral Immunity?
Authors: Melenotte Cléa , Pontarotti Pierre , Pinault Lucile , Mège Jean-Louis , Devaux Christian , Raoult Didier 
Published: September 2021

It has been reported that treatment with β-lactam antibiotics induces leukopenia and candidemia, worsens the clinical response to anticancer immunotherapy and decreases immune response to vaccination. β-lactamases can cleave β-lactam antibiotics by blocking their activity. Two distincts superfamilies of β-lactamases are described, the serine β-lactamases and the zinc ion dependent metallo-β-lactamases. In human, 18 metallo-β-lactamases encoding genes (hMBLs) have been identified. While the physiological role of most of them remains unknown, it is well established that the SNM1A, B and C proteins are involved in DNA repair. The SNM1C/Artemis protein is precisely associated in the V(D)J segments rearrangement, that leads to immunoglobulin (Ig) and T-cell receptor variable regions, which have a crucial role in the immune response. Thus in humans, SNM1C/Artemis mutation is associated with severe combined immunodeficiency characterized by hypogammaglobulinemia deficient cellular immunity and opportunistic infections. While catalytic site of hMBLs and especially that of the SNM1 family is highly conserved, in vitro studies showed that some β-lactam antibiotics, and precisely third generation of cephalosporin and ampicillin, inhibit the metallo-β-lactamase proteins SNM1A &amp; B and the SNM1C/Artemis protein complex. By analogy, the question arises as to whether β-lactam antibiotics can block the SNM1C/Artemis protein in humans inducing transient immunodeficiency. We reviewed here the literature data supporting this hypothesis based on in silico, in vitro and in vivo evidences. Understanding the impact of β-lactam antibiotics on the immune cell will offer new therapeutic clues and new clinical approaches in oncology, immunology, and infectious diseases.
Gimap5 Inhibits Lung Cancer Growth by Interacting With M6PR
Authors: Dai Pei , Tang Zhongxiang , Ruan Pinglang , Bajinka Ousman , Liu Dan , Tan Yurong 
Published: September 2021

ObjectiveSeveral studies have demonstrated the impacts of GTPases of immunity-associated proteins (GIMAPs) on malignant cells. However, the mechanisms through which Gimap5 regulates lung cancer cells are yet to be thoroughly investigated in the literature. Our study aimed to investigate the function of Gimap5 in the development of lung cancer.MethodsThe expression levels of the GIMAP family were analyzed in lung cancer patients of various cancer databases and lung cancer cell lines. After the survival rates of the cells were analyzed, we constructed Gimap5 over-expressed lung cancer cell lines and assessed the effects of Gimap5 on cell migration, cell invasion, cell proliferation and the epithelial-mesenchymal transition (EMT). We later screened the interacting proteins of Gimap5 using Co-IP combined with mass spectrometry and then analyzed the expression and distribution of M6PR, including its impacts on protein-arginine deiminase type-4 (PADI4).ResultsFindings indicated that GIMAP family expression decreased significantly in lung cancer cell lines. We also noticed that the downregulation of the GIMAP family was related to the poor prognosis of lung cancer patients. Our experimental results showed that Gimap5 could inhibit the migration, invasion, proliferation and EMT of lung cancer cell lines. Moreover, we found that Gimap5 promoted the transport of M6PR from the cytoplasm to the cell membrane, thereby inhibiting the enhancement of EMT-related PADI4.ConclusionOur research suggested that Gimap5 could inhibit the growth of lung cancer by interacting with M6PR and that it could be a potential biomarker for the diagnosis and prognosis of lung cancer.
Clinical Outcome of CT-Guided Stereotactic Ablative Brachytherapy for Unresectable Early Non-Small Cell Lung Cancer: A Retrospective, Multicenter Study
Authors: Ji Zhe , Huo Bin , Liu Shifeng , Liang Qinghua , Xing Chao , Hu Miaomiao , Ma Yanli , Wang Zhe , Zhao Xinxin , Song Yuqing , Wang Yufeng , Han Hongmei , Zhang Kaixian , Wang Ruoyu , Chai Shude , Huang Xuequan , Hu Xiaokun , Wang Junjie 
Published: September 2021

ObjectiveTo analyze the efficacy and safety of low dose rate stereotactic ablative brachytherapy (L-SABT) for treatment of unresectable early-stage non-small cell lung cancer (NSCLC).MethodsData of patients with early-stage NSCLC who received CT-guided L-SABT (radioactive I-125 seeds implantation) at eight different centers from December 2010 to August 2020 were retrospectively analyzed. Treatment efficacy and complications were evaluated.ResultsA total of 99 patients were included in this study. Median follow-up duration was 46.3 months (6.1-119.3 months). The 1-year, 3-year, and 5-year local control rates were 89.1%, 77.5%, and 75.7%, respectively. The 1-year, 3-year, and 5-year overall survival rates were 96.7%, 70.1%, and 54.4%, respectively. Treatment failure occurred in 38.4% of patients. Local/regional recurrence, distant metastasis, and recurrence combined with metastasis accounted for 15.1%, 12.1%, and 11.1%, respectively. Pneumothorax occurred in 47 patients (47.5%) with 19 cases (19.2%) needing closed drainage. The only radiation-related adverse reaction was two cases of grade 2 radiation pneumonia. KPS 80–100, T1, the lesion was located in the left lobe, GTV D90 ≥150 Gy and the distance between the lesion and chest wall was &lt; 1 cm, were associated with better local control (all P &lt; 0.05); on multivariate analysis KPS, GTV D90, and the distance between the lesion and chest wall were independent prognostic factors for local control (all P &lt; 0.05). KPS 80–100, T1, GTV D90 ≥150 Gy, and the distance between the lesion and chest wall was &lt; 1 cm were also associated with better survival (all P &lt; 0.05); on multivariate analysis KPS, T stage, and GTV D90 were independent prognostic factors for survival (all P &lt; 0.05). The incidence of pneumothorax in patients with lesions &lt;1 cm and ≥1cm from the chest wall was 33.3% and 56.7%, respectively, and the differences were statistically significant (P = 0.026).ConclusionL-SABT showed acceptable efficacy in the treatment of unresectable early-stage NSCLC. But the incidence of pneumothorax is high. For patients with T1 stage and lesions &lt;1 cm from the chest wall, it may have better efficacy. Prescription dose greater than 150 Gy may bring better results.
Trimetazidine Attenuates Heart Failure by Improving Myocardial Metabolism via AMPK
Authors: Shu Hongyang , Hang Weijian , Peng Yizhong , Nie Jiali , Wu Lujin , Zhang Wenjun , Wang Dao Wen , Zhou Ning 
Published: September 2021

Energic deficiency of cardiomyocytes is a dominant cause of heart failure. An antianginal agent, trimetazidine improves the myocardial energetic supply. We presumed that trimetazidine protects the cardiomyocytes from the pressure overload-induced heart failure through improving the myocardial metabolism. C57BL/6 mice were subjected to transverse aortic constriction (TAC). After 4 weeks of TAC, heart failure was observed in mice manifested by an increased left ventricular (LV) chamber dimension, an impaired LV ejection fraction evaluated by echocardiography analysis, which were significantly restrained by the treatment of trimetazidine. Trimetazidine restored the mitochondrial morphology and function tested by cardiac transmission electron microscope and mitochondrial dynamic proteins analysis. Positron emission tomography showed that trimetazidine significantly elevated the glucose uptake in TAC mouse heart. Trimetazidine restrained the impairments of the insulin signaling in TAC mice and promoted the translocation of glucose transporter type IV (GLUT4) from the storage vesicle to membrane. However, these cardioprotective effects of trimetazidine in TAC mice were notably abolished by compound C (C.C), a specific AMPK inhibitor. The enlargement of neonatal rat cardiomyocyte induced by mechanical stretch, together with the increased expression of hypertrophy-associated proteins, mitochondria deformation and dysfunction were significantly ameliorated by trimetazidine. Trimetazidine enhanced the isolated cardiomyocyte glucose uptake in vitro. These benefits brought by trimetazidine were also removed with the presence of C.C. In conclusion, trimetazidine attenuated pressure overload-induced heart failure through improving myocardial mitochondrial function and glucose uptake via AMPK.