bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interações Fármaco-fármaco em Prescrições de Pacientes em Unidade de Terapia Intensiva Adulto em Hospital Público de Montes Claros
Authors: Lima Anna Lívia , Lopes Kelly Cristiane , Marinho Esther Alves , Figueredo Flávio Júnior , Duarte Cecília Paiva , Vasconcelos Viviane de Oliveira , Lima Izabella Mendes , Monção Thiago Santos , Reis Guilherme Henrique Azevedo dos , Gomes Yves André Rodrigues , Teixeira Vítor Batista , José Neto Antônio , Barbosa Ana Júlia Oliveira , Mota João Victor Nepomuceno , Rocha Matheus Ribeiro , Costa Rafael Araújo , Cardoso Edson Rabelo , Silva Valéria Crisley Mendes , Paula-Júnior Waldemar de , Guimarães Talita Antunes 
Published: February 2025

Pacientes em Unidades de Terapia Intensiva (UTI) frequentemente recebem múltiplos medicamentos simultaneamente, o que aumenta o risco de interações farmacológicas, as quais podem ser potencialmente graves. Por isso, uma equipe multidisciplinar que faça a análise e revisão das prescrições é de extrema importância, pois reduz significativamente o risco de interações. Nesse sentido, o presente trabalho objetivou acompanhar o serviço de farmácia clínica prestado aos pacientes internados na UTI Adulto em um hospital público na cidade de Montes Claros/MG. Foi realizada uma pesquisa transversal, quantitativa, documental e descritiva, por meio do levantamento das prescrições diárias. A partir das análises de prescrições eletrônicas via Sistema MV®, foram analisados todos os medicamentos presentes na prescrição a partir do aplicativo MICROMEDEX®. Diante disso, foram selecionadas as possíveis Interações Fármaco-fármaco (pIFF). As Prescrições Médicas emitidas foram analisadas no período de 01 de agosto a 30 de setembro de 2023. Foram classificadas somente as pIFF que apresentem interação maior. Observou-se, neste estudo, que 15,40% das prescrições analisadas corresponderam à interação entre metoclopramida e insulina humana regular, associação que pode desencadear hiperglicemia devido a interações farmacocinéticas; 10,36% corresponderam à interação entre morfina e metoclopramida, representando risco aumentado de depressão do SNC; e em 7,84% das prescrições observou-se a interação entre fentanil e metoclopramida, associação essa que deve ser evitada, exigindo aumento da monitorização para minimizar efeitos adversos. Conclui-se que a identificação das interações mais prevalentes é de suma importância para evitar situações de potenciais falhas terapêuticas e/ou diminuírem os problemas relacionados ao medicamento.
Die geänderten Vorschriften zur Verrechnungspreisdokumentation
Authors: Quilitzsch Carsten , Hörnicke Gabriel , Broszeit Jan 
Published: February 2025

Zusammenfassung
Die Erstellung und fristgerechte Vorlage der Verrechnungspreisdokumentation zählt zu den wesentlichsten Mitwirkungspflichten Steuerpflichtiger mit internationalen Geschäftsbeziehungen. Mit dem Ziel, überbordende Bürokratie im Bereich des Steuerrechts abzubauen, haben die Vorschriften in § 90 Abs. 3 und 4 AO jüngst eine Revision durch das Vierte Bürokratieentlastungsgesetz v. 29.10.2024 (BGBl. I 2024, Nr. 323) erfahren. Die Neuregelungen sind am 1.1.2025 in Kraft getreten. Sie werden nachstehend dargestellt. Dabei wird ebenso der Frage nachgegangen, ob man dem Gesetzgeber bescheinigen darf, der Zielsetzung signifikanten Bürokratieabbaus an dieser Stelle ausreichend Rechnung getragen zu haben.
Factors in Initial Anticoagulation Choice in Hospitalized Patients With Pulmonary Embolism
Authors: Stubblefield William B. , Helderman Ron , Strokes Natalie , Greineder Colin F. , Barnes Geoffrey D. , Vinson David R. , Westafer Lauren M. 
Published: January 2025

ImportanceDespite guideline recommendations to use low-molecular-weight heparins (LMWHs) or direct oral anticoagulants in the treatment of most patients with acute pulmonary embolism (PE), US-based studies have found increasing use of unfractionated heparin (UFH) in hospitalized patients.ObjectiveTo identify barriers and facilitators of guideline-concordant anticoagulation in patients hospitalized with acute PE.Design, Setting, and ParticipantsThis qualitative study conducted semistructured interviews from February 1 to June 3, 2024, that were recorded, transcribed, and analyzed in an iterative process using reflexive thematic analysis. Interview participants were physicians in emergency medicine, hospital medicine (hospitalist), interventional cardiology, and interventional radiology. Participants were recruited using maximum variation sampling targeting UFH-dominant vs LMWH-dominant approaches in hospitalized patients with acute PE. We triangulated results with a group of interventional cardiologists and radiologists (interventionalists).Main Outcomes and MeasuresCommon themes and factors associated with anticoagulant selection for hospitalized patients with acute PE. Reflexive thematic analysis was used to identify these themes and factors.ResultsOf the 46 interviewees (median [IQR] age, 43 [36-50] years; 33 who identified as men [71.7%]), 25 (54.3%) were emergency physicians, 17 (37.0%) were hospitalists, and 4 (8.7%) were interventionalists. Each interview lasted a median (IQR) of 29 (25-32) minutes. Prominent themes associated with anticoagulant selection included agnosticism regarding choice of anticoagulant, the inertia of learned practice, and therapeutic momentum after anticoagulation initiation. Institutional culture and support were factors associated with choice of the dominant anticoagulation strategy. Additionally, factors associated with UFH use were fear of decompensation and misperceptions regarding the pharmacology of anticoagulants and catheter-directed treatments.Conclusions and RelevanceIn this qualitative study, physicians across a spectrum of specialties and geographical settings reported common barriers and facilitators to the use of guideline-concordant anticoagulation in patients hospitalized with acute PE, particularly agnosticism regarding choice of anticoagulant, inertia of learned practice, therapeutic momentum after anticoagulation initiation, and institutional culture and support. Future implementation efforts may consider targeting these domains.
Lying Under Pressure: Examining the Impact of Stress and Veracity on Verbal and Nonverbal Behaviors in Credibility Judgments
Authors: Bogaard Glynis , Dimopoulos Rafail , Quaedflieg Conny W. E. M. 
Published: January 2025

ABSTRACTIn four experiments, we investigated how stress influenced the perceived verbal and nonverbal behaviors of honest and deceptive senders and how it affected credibility judgments made by independent observers. We used the Maastricht Acute Stress Test to induce stress in senders. Independent observers evaluated videos (Experiments 1 and 3) or transcripts (Experiments 2 and 4) of these senders reporting honestly or deceptively. Our results showed that stress significantly influenced observers' judgments of nonverbal behaviors but had a limited effect on content evaluations (plausibility, believability, and accuracy). Instead, veracity predominantly shaped credibility assessments, with plausibility and believability emerging as indicators of truthfulness. The findings challenge the reliance on nonverbal cues in detecting deception and emphasize the need of considering situational factors. Furthermore, they underscore the importance of prioritizing verbal content in professional lie‐detection practices.
Sustainable Synthesis of Functional Materials Assisted by Deep Eutectic Solvents for Biomedical, Environmental, and Energy Applications
Authors: Nie Yingxia , Zhou Yuyue , Zhang Yan , Sun Dalin , Wu Deyu , Ban Lin , Nanda Sonil , Xu Chunbao , Zhang Heng 
Published: January 2025

AbstractThe rapid expansion of the global economy has led to a surge in energy demand, resulting in significant environmental pollution and energy scarcity due to the concomitant increase in greenhouse gas emissions. The advancement of deep eutectic solvents (DESs) has introduced a viable substitute for traditional solvents and processing methods, boasting numerous intrinsic benefits, such as superior eco‐compatibility, outstanding thermal stability, and desirable electrochemical properties. Consequently, DESs have garnered significant attention from the research community, demonstrating a broad spectrum of prospective applications in a variety of fields for instance energy, biomass degradation, materials synthesis, and biomedicine. This review aims to offer a comprehensive and methodical overview of DESs, encompassing their historical development, classification, preparation methodologies, and fundamental physicochemical properties. Furthermore, this review explores the applications of DESs in the synthesis of various functional materials and examines their multifunctional roles. Crucially, the economic viability of DESs for environmental and energy applications is thoroughly examined, including an assessment of their cost‐effectiveness and market potential. Finally, the review concludes by outlining future research directions for DESs development and the challenges that remain.
Selective Recycling of Mixed Polyesters via Heterogeneous Photothermal Catalysis
Authors: Liu Yu , Yan Penglei , Li Xiaodong , Li Qingye , Li Shengming , Han Hao , Chu Mingyu , Fu Jie , Cao Muhan , Xu Panpan , Zhang Qiao , He Le , Chen Jinxing 
Published: January 2025

AbstractThe selective recycling of mixed plastic wastes with similar structural units is challenging. While heterogeneous catalysis shows potential for selective recycling, challenges such as complex mass transfer at multiphase interfaces and unclear catalytic mechanisms have slowed progress. In this study, a breakthrough in recycling mixed polyester wastes is introduced using heterogeneous photothermal catalysis. By adding co‐solvents, the difficulties associated with multiphase interfacial mass transfer are overcome. Grain boundary (GB)‐rich CeO2 photothermal catalysts are used to selectively glycolyze mixed poly(ethylene terephthalate) (PET) and poly(bisphenol A carbonate) (PC) plastics into bisphenol A (BPA) and bis(2‐hydroxyethyl) terephthalate (BHET), achieving yields of 97.8% and 93.4%, respectively. The high concentration of oxygen vacancies in GB‐rich CeO2 catalysts adjusts the adsorption energy of intermediates, leading to more selective and efficient depolymerization compared to GB‐poor CeO2 catalysts. The economic and environmental analysis demonstrates that this process, which utilizes heterogeneous photothermal catalysis, provides significant energy savings and carbon reduction, representing a major advancement in mixed plastic waste recycling.
Toward Fast‐Charging and Dendritic‐Free Li Growth on Natural Graphite Through Intercalation/Conversion on MoS2 Nanosheets
Authors: Suh Joo Hyeong , Han Sang A , Yang Soo Young , Lee Jun Won , Shimada Yusuke , Lee Sang‐Min , Lee Jong‐Won , Park Min‐Sik , Kim Jung Ho 
Published: January 2025

AbstractDuring fast‐charging, uneven lithium plating on the surface of commercial graphite anode impedes the electrochemical performance of lithium‐ion batteries, causing a safety issue. The formation of a passivation layer, the solid‐electrolyte interphase (SEI), due to side reactions with the organic electrolyte, correlates with long‐term cycling performance under fast‐charging conditions, necessitating comprehensive analysis. Herein, it is demonstrated that a molybdenum disulfide (MoS2) coating on natural graphite (NG) modulates the properties of the SEI layer, enabling reduction of the charging time and the enhancement of long‐term cycling performance. MoS2 spontaneously transforms into Li2S and Mo nanoclusters through intercalation and conversion with Li+, altering the chemical composition and stability of the SEI layer on the NG, promoting faster Li+ transport, and reducing interfacial resistance. The MoS2‐NG anode shows improved fast‐charging capability and cycling performance under 3.0 C‐charging and 1.0 C‐discharging over 300 cycles without compromising energy density. In the full‐cell configuration, a charging time of 14.7 min at 80% state of charge is achieved, making it suitable for electric vehicle applications.
A Low‐Cost, Open‐Source 3D Printer for Multimaterial and High‐Throughput Direct Ink Writing of Soft and Living Materials
Authors: Weiss Jonathan D. , Mermin‐Bunnell Alana , Solberg Fredrik S. , Tam Tony , Rosalia Luca , Sharir Amit , Rütsche Dominic , Sinha Soham , Choi Perry S. , Shibata Masafumi , Palagani Yellappa , Nilkant Riya , Paulvannan Kiruthika , Ma Michael , Skylar‐Scott Mark A. 
Published: January 2025

AbstractDirect ink writing is a 3D printing method that is compatible with a wide range of structural, elastomeric, electronic, and living materials, and it continues to expand its uses into physics, engineering, and biology laboratories. However, the large footprint, closed hardware and software ecosystems, and expense of commercial systems often hamper widespread adoption. This work introduces a compact, low‐cost, multimaterial, and high‐throughput direct ink writing 3D printer platform with detailed assembly files and instructions provided freely online. In contrast to existing low‐cost 3D printers and bioprinters, which typically modify off‐the‐shelf plastic 3D printers, this system is built from scratch, offering a lower cost and full customizability. Active mixing of cell‐laden bioinks, high‐throughput production of auxetic lattices using multimaterial multinozzle 3D (MM3D) printing methods, and a high‐toughness, photocurable hydrogel for fabrication of heart valves are introduced. Finally, hardware for embedded multinozzle and 3D gradient nozzle printing is developed for producing high‐throughput and graded 3D parts. This powerful, simple‐to‐build, and customizable printing platform can help stimulate a vibrant biomaker community of engineers, biologists, and educators.
Understanding the Dynamic Evolution of Active Sites among Single Atoms, Clusters, and Nanoparticles
Authors: Yang Hongchen , Duan Pengfei , Zhuang Zechao , Luo Yaowu , Shen Ji , Xiong Yuli , Liu Xiangwen , Wang Dingsheng 
Published: January 2025

AbstractCatalysis remains a cornerstone of chemical research, with the active sites of catalysts being crucial for their functionality. Identifying active sites, particularly during the reaction process, is crucial for elucidating the relationship between a catalyst's structure and its catalytic property. However, the dynamic evolution of active sites within heterogeneous metal catalysts presents a substantial challenge for accurately pinpointing the real active sites. The advent of in situ and operando characterization techniques has illuminated the path toward understanding the dynamic changes of active sites, offering robust scientific evidence to support the rational design of catalysts. There is a pressing need for a comprehensive review that systematically explores the dynamic evolution among single atoms, clusters, and nanoparticles as active sites during the reaction process, utilizing in situ and operando characterization techniques. This review aims to delineate the effects of various reaction factors on dynamic evolution of active sites among single atoms, clusters, and nanoparticles. Moreover, several in situ and operando techniques are elaborated with emphases on tracking the dynamic evolution of active sites, linking them to catalytic properties. Finally, it discusses challenges and future perspectives in identifying active sites during the reaction process and advancing in situ and operando characterization techniques.
Highly Efficient Monolithic Perovskite/TOPCon Silicon Tandem Solar Cells Enabled by “Halide Locking”
Authors: Wang Lina , Wang Ning , Wu Xin , Liu Baoze , Liu Qi , Li Bo , Zhang Dong , Kalasariya Nikhil , Zhang Yuanfang , Yan Xunlei , Wang Jungan , Zheng Peiting , Yang Jie , Jin Hao , Wang Chenyue , Qian Liangchen , Yang Bin , Wang Yan , Cheng Xuelan , Song Tinglu , Stolterfoht Martin , Zeng Xiao Cheng , Zhang Xinyu , Xu Menglei , Bai Yang , Xu Fang , Zhou Cangtao , Zhu Zonglong 
Published: January 2025

AbstractPerovskite/silicon tandem solar cells (TSCs) are promising candidates for commercialization due to their outstanding power conversion efficiencies (PCEs). However, controlling the crystallization process and alleviating the phases/composition inhomogeneity represent a considerable challenge for perovskite layers grown on rough silicon substrates, ultimately limiting the efficiency and stability of TSC. Here, this study reports a “halide locking” strategy that simultaneously modulates the nucleation and crystal growth process of wide bandgap perovskites by introducing a multifunctional ammonium salt, thioacetylacetamide hydrochloride (TAACl), to bind with all types of cations and anions in the mixed halide perovskite precursor. The approach not only enables excellent compositional uniformity in the wet‐film stage but also induces preferred orientation along the (001) plane following nucleation, leading to enhanced homogeneity of the perovskite film in both vertical and horizontal directions over long‐length scales. The resulting wide‐bandgap perovskite solar cells yield exceptional open‐circuit voltage‐fill factor products (VOC × FF) of 1.074 and 1.040 in small‐ (0.0414 cm2) and large‐area (1.0208 cm2) devices, respectively. Corresponding large‐area tandem solar cells based on the Tunnel Oxide Passivated Contact (TOPCon) silicon subcells achieve a record PCE of 31.32% with a remarkable VOC of 1.931 V and FF of 81.54%.
Synthesis of Semiconductor Zinc Sulfide Nanospheres for Improving Piezoresistive Sensing Behavior of Melt‐Mixed Poly(vinylidene fluoride)/Carbon Nanotube Composites
Authors: Kaplan Müslüm , Alp Emre , Krause Beate , Boldt Regine , Pötschke Petra 
Published: January 2025

AbstractStudies have increasingly aimed at improving the piezoresistive behavior of polymer‐based conductive composites (CPCs) for strain‐sensing, with inorganic nanomaterial enhancement offering research opportunities. This study investigates the impact of incorporating zinc sulfide nanospheres (ZnS NSs, 1–7 wt.%), synthesized via a one‐step hydrothermal method, into a poly(vinylidene fluoride) (PVDF) polymer matrix together with multi‐walled carbon nanotubes (MWCNTs). Field emission scanning electron microscopy (FE‐SEM), energy‐dispersive X‐ray spectroscopy (EDX), and X‐ray diffraction (XRD) analyses reveal that ZnS NSs comprise a mixture of ZnS0.96O0.04 and S phases. While of ZnS NSs minimally impact tensile properties of the PVDF/MWCNT composites, they reduce elongation at break at 5 wt.%. During 15‐cycle strain sensing up to 3% strain, ZnS NSs‐enhanced composites outperformed PVDF/1 wt.% MWCNT. The reference sample's resistance change ratio (ΔR/R0) decreased below 1% with increased cycles, while 1 wt.% ZnS NSs increased ΔR/R0 to 3%, reducing changes upon cycle increments. Higher ZnS NSs levels (3–7 wt.%) resulted in ΔR/R0 exceeding 4–5%, indicating enhanced strain sensing performance. Fourier‐transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA) showed limited impact of ZnS NSs on the thermal properties and microstructure of the composites.
Thermally Activated Delayed Fluorescence Dye‐Sensitized Down‐Conversion Nanoparticles for Near‐Infrared Luminescence Enhancement
Authors: Liu Tongtong , Liang Ning , Liu Xiaomeng , Li Jiaqi , Tu Langping , Liu Jianxun , Feng Yansong , Yao Chang‐Jiang 
Published: January 2025

AbstractDye‐sensitized down‐conversion nanoparticles (DCNPs) can significantly enhance photon absorption, bridging the gap of narrow and weak absorption cross‐section of lanthanide (Ln) ions, thus fundamentally prompting their near‐infrared (NIR) emission. However, the ideal strategy for utilization of both the singlet and triplet energy of the dyes is hindered by the nanostructures and the dependence on the heavy atom effect. Herein, thermally activated delayed fluorescence (TADF) dye is utilized with a small singlet‐triplet energy gap as the absorption antenna, achieving a 733 fold emission enhancement. This strategy facilitates efficient intersystem crossing (ISC) and reverse intersystem crossing (RISC) processes, enabling effective energy transfer from singlet (S1) and triplet (T1) excitons to emitted energy levels of Er3+. Combining highly Erbium‐doped nanoparticles, the water‐dispersed AD‐sensitized system shows excellent hydrodynamic stability and photostability. This innovative approach marks the first report of TADF dye‐sensitized Ln nanosystems, offering a new direction for photo conversion technology.
Photothermal Effect and Biomineralization of Black Phosphorus Nanosheet‐Composited Hydrogel Boosts Synergistic Treatment of Dentin Hypersensitivity
Authors: Wang Qihui , Wang Guoliang , Li Xinru , Li Di , Zhang Congxiao , Ding Jianxun 
Published: January 2025

AbstractDentin hypersensitivity (DH), marked by exposed dentinal tubules, presents as a sharp toothache triggered by stimuli and subsides when the stimuli are removed. To address the limitations of current commercial desensitizers in terms of acid resistance, friction resistance, and stability, a black phosphorus nanosheet‐composited methacrylate gelatin hydrogel (GelMA/BP) is developed for DH treatment, leveraging the synergistic effects of photothermal therapy and biomineralization. Incorporating the BP nanosheet provided GelMA/BP with a stable photothermal response and the continuous release of phosphate anions, which blocked dentinal tubules by converting light energy into heat and initiating biomineralization. In vitro desensitizing therapy showed that the dentinal tubule diameter in the GelMA/BP50 group (0−1.13 µm) is significantly reduced compared to that in the DH‐model group (0−3.14 µm). The GelMA/BP50 group achieved an 86% tubule occlusion rate, with acid resistance of 80%, friction resistance of 76%, and long‐term stability of 74%. In vivo studies further validated the efficacy of GelMA/BP50, showing a reduction in tubule diameter (0−0.37 µm) and an occlusion rate of 79%, which alleviated toothache and increased intake and weight. These results demonstrate that this desensitizing hydrogel acts as an effective dentinal tubule sealant, offering promising clinical benefits for the topical treatment of DH.
Elucidating Manganese Single‐Atom Doping: Strategies for Fluorescence Enhancement in Water‐Soluble Red‐Emitting Carbon Dots and Applications for FL/MR Dual Mode Imaging
Authors: Gao Fucheng , Fu Qiang , Ruan Ying , Li Can , Wang Yandong , Li Hui , Li Jichao , Jiang Yanyan 
Published: January 2025

AbstractThe absence of the enhancement of fluorescence in carbon dots (CDs) through doping with transition metal atoms (TMAs) hinders the advancement of multi‐modal bio‐imaging CDs with high photoluminescence quantum yield (PLQY). Herein, Mn‐atomically‐doped R‐CDs (R‐Mn‐CDs) with a high PLQY of 41.3% in water is presented, enabling efficient in vivo dual‐mode fluorescence/magnetic resonance (MR) imaging. The comprehensive characterizations reveal that the incorporation of Mn atoms leads to a Mn‐N2O2 coordinating structure, resulting in five significant effects: an increase in sp2 conjugation domains, a reduction in band gap, a decreased oxidation level, an increase in photo‐excited electron numbers, and the suppression of non‐radiative electron relaxation pathways. Collectively, these factors contribute to the remarkable PLQY of R‐Mn‐CDs. Additionally, the doping of Mn atoms also endows R‐Mn‐CDs with superior MR imaging capabilities due to, which highlights their promising prospect as a dual‐modal bio‐imaging platform for fluorescence/MR imaging. Furthermore, the findings indicate that the introduction of various TMAs, such as Mn, Zn, Ni, and Cu, can universally improve the PLQY of water‐soluble CDs through the construction of TMAs─O bonds. This research provides valuable theoretical insights into the mechanisms underlying the fluorescence enhancement induced by TMAs doping and offers guidance for the future design of high PLQY CDs.