bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of the Methotrexate Experience Questionnaire, a new methotrexate oral treatment adherence tool in rheumatoid arthritis
Authors: Curtis Jeffrey R. , Nebesky Jan Michael , de Bock Elodie , de la Loge Christine , Arnould Benoit , Davey Robert , Devenport Jenny , Pethö-Schramm Attila 
Published: August 2021

Abstract
Objective
Despite the development of new biologic therapies, methotrexate (MTX) remains the preferred initial disease-modifying anti-rheumatic drug to treat rheumatoid arthritis (RA). Adherence to disease-modifying anti-rheumatic drugs is suspected to be highly variable potentially leading to reduced treatment effectiveness. This work aimed to develop and validate the Methotrexate Experience Questionnaire (MEQ), a tool to identify and characterize non-adherence to oral MTX.

Methods
MEQ development included a literature review and qualitative interviews with RA patients and physicians in the United States. A retrospective, cross-sectional study using data from Optimum Patient Care Research Database, a large primary care database of electronic medical records in the United Kingdom, was conducted to finalize the MEQ and evaluate its psychometric properties.

Results
Three hundred seven e-consented subjects (66% women, mean age of 65 years) completed the MEQ remotely, and were included in this analysis. Item-convergent and divergent validity were generally supportive of the construct validity of the MEQ and Cronbach’s alpha of 0.87 supported its reliability. The MEQ Total score presented statistically significant correlations of small to medium size with all selected concurrent scales, as expected; the highest correlation was obtained between the general acceptance score of ACCEPT and the MEQ Total score (0.55, p < 0.001). Known-groups validity was demonstrated as a logical pattern of higher MEQ scores was obtained for patients considered adherent with both the 6- and 12-month Proportion of Days Covered (mean MEQ total score 82.7 for 12-month PDC ≥ 80% against 76.3 for 12-month PDC < 80%, p< 0.0001). Additionally, a pattern of lower MEQ scores was obtained for patients with more severe disease assessed with Routine Assessment of Patient Index Data 3.

Conclusion
The 24-item MEQ is a reliable and valid instrument to assess the adherence of RA patients taking MTX, potentially improving over historical refill rate metrics by providing insights into the individual reasons for lack of adherence. This information should facilitate clinician-patient discussions and help inform treatment decisions.
Responsiveness of Nepali version of Oswestry Disability Index (ODI) on individuals with non-specific low back pain
Authors: Binaya Kandel , Kajal Thapa , Ranjeeta Acharya S. , Govinda Nepal 
Published: August 2021

Abstract
Background
Low back pain (LBP) is a common musculoskeletal problem, associated with disability and high societal costs. The Oswestry Disability Index (ODI) is among the most commonly used patient reported outcome measures to measure disability due to LBP. Evidence supporting the reliability and validity of the Nepali Version of Oswestry Disability Index (NODI) exists, but its responsiveness is yet to be assessed.

Objective
We aimed to assess the responsiveness of NODI in participants with non-specific low back pain.

Methods
The study included 102 (Male 41, Female 61) participants with non-specific low back pain, attending the physiotherapy outpatient department of a tertiary care hospital and nearby community. The NODI was administered to the patients at baseline and again 2 weeks later along with a 7-item Nepali Version of Global Rating of Change (GROC-NP). Responsiveness of NODI was assessed by plotting Receivers Operating Characteristics (ROC) curve.

Results
The area under curve (AUC) of NODI was 0.88. The best cut-off point on the NODI for improvement on the GROC-NP or the minimal clinical important change (MIC) was 4.22 and ranged from 3.11 to 6.34. The sensitivity and specificity was 77.4% and 84.2% respectively.

Conclusion
NODI is a responsive scale which can discriminate between participants whose level of disability due to LBP is stable or improving. The result for minimal clinically important change, sensitivity and specificity are consistent with other cross culturally adopted versions.
Spatiotemporal characteristics of GNSS-derived precipitable water vapor during heavy rainfall events in Guilin, China
Authors: Huang Liangke , Mo Zhixiang , Xie Shaofeng , Liu Lilong , Chen Jun , Kang Chuanli , Wang Shitai 
Published: August 2021

AbstractPrecipitable Water Vapor (PWV), as an important indicator of atmospheric water vapor, can be derived from Global Navigation Satellite System (GNSS) observations with the advantages of high precision and all-weather capacity. GNSS-derived PWV with a high spatiotemporal resolution has become an important source of observations in meteorology, particularly for severe weather conditions, for water vapor is not well sampled in the current meteorological observing systems. In this study, an empirical atmospheric weighted mean temperature (Tm) model for Guilin is established using the radiosonde data from 2012 to 2017. Then, the observations at 11 GNSS stations in Guilin are used to investigate the spatiotemporal features of GNSS-derived PWV under the heavy rainfalls from June to July 2017. The results show that the new Tm model in Guilin has better performance with the mean bias and Root Mean Square (RMS) of − 0.51 and 2.12 K, respectively, compared with other widely used models. Moreover, the GNSS PWV estimates are validated with the data at Guilin radiosonde station. Good agreements are found between GNSS-derived PWV and radiosonde-derived PWV with the mean bias and RMS of − 0.9 and 3.53 mm, respectively. Finally, an investigation on the spatiotemporal characteristics of GNSS PWV during heavy rainfalls in Guilin is performed. It is shown that variations of PWV retrieved from GNSS have a direct relationship with the in situ rainfall measurements, and the PWV increases sharply before the arrival of a heavy rainfall and decreases to a stable state after the cease of the rainfall. It also reveals the moisture variation in several regions of Guilin during a heavy rainfall, which is significant for the monitoring of rainfalls and weather forecast.
Effect of Ubiquinol supplementation on ovulation induction in Clomiphene Citrate resistance
Authors: Ammar Islam Mohamed Magdi , Abdou Ahmed Mahmoud 
Published: August 2021

Abstract
Background
Clomiphene Citrate is considered the gold-standard for induction of ovulation and has been used for several years to treat PCOS related infertility. Unfortunately, 15-40% of women with PCOS are resistant to Clomiphene Citrate. The study aimed to evaluate potential benefits of adding the active form of Coenzyme Q10 (Ubiquinol) to Clomiphene Citrate compared with Human Menopausal Gonadotropins (hMG) in Clomiphene Citrate resistant PCOS patients. 148 PCOS Patients with Clomiphene Citrate resistance were randomized into two groups (A and B). In group A, controlled ovarian stimulation was done by Clomiphene Citrate 150 mg daily (from 2nd till 6th day of cycle) together with Ubiquinol starting from 2nd day till day of hCG triggering in a dose of 100 mg orally once daily. In group B, hMG was given from 2nd day of the cycle in a dose ranging from 75 to 225 IU. Serial transvaginal ultrasonography was done starting on cycle day 8 and continued till size of leading follicle reaches 18 mm or more then ovulation triggering was done. Thereafter, patients were advised for a timed intercourse (TI) after 36 hours. A blood sample was withdrawn seven days after hCG triggering, for measurement of serum progesterone. If the Patient presented with a missed period for one week, a serum sample was sent for β-hCG.

Results
There were no statistically significant differences (P > 0.05) between studied groups regarding; number of cases reaching mature follicular size, number of stimulated cycles, endometrial thickness on the day of hCG triggering, mid-luteal serum progesterone, positive serum pregnancy test and clinical pregnancy rate.

Conclusions
Addition of Ubiquinol to Clomiphene Citrate improved ovarian responsiveness in Clomiphene Citrate resistant patients with results comparable to conventional hMG stimulation protocol.
Can trans-cerebellar diameter supersede other fetal biometry in measuring gestational age? A prospective study
Authors: George Rintu , Amirthalingam Umamageswari , Hussain Mohamed Rafi Kathar , Aditiya Vigneshwar , Anand A. M. , Padmanaban Elamparidhi , Kulasekeran N. 
Published: August 2021

Abstract
Background
Estimation of gestational age plays a pivotal role in day to day clinical practice for appropriate management of newborn. The trans-cerebellar diameter can predict gestational age in cases of variations of fetal head shape such as dolichocephaly and brachycephaly or even when fetus is in posterior position. Trans-cerebellar diameter (TCD) may be useful in gestational age estimation.

Aim and methodology
To determine the accuracy of trans-cerebellar diameter in the estimation of gestational age of fetus and comparing the conventional parameters like head circumference, biparietal diameter, abdominal circumference and femur length in the measurement of gestational age. This is a prospective, cross-sectional analytical study done in the Radiology Department in those patients who were referred to the department for a routine antenatal ultra-sonogram checkup.

Results
Comparison of trans-cerebellar diameter with gestational age derived from last menstrual period indicates that there is a linear relationship throughout the gestational ages. There is a strong correlation of trans-cerebellar diameter with other conventional parameters namely biparietal diameter, femur length and abdominal circumference of which Femur length correlates well with the trans-cerebellar diameter. Correlation of transcerebellar diameter with gestational age shows a R2 of 0.995 (p value < 0.001).

Conclusion
Trans-cerebellar diameter is best in estimation of gestational age when compared to biparietal diameter, femur length and abdominal circumference. The regression formula derived from trans-cerebellar diameter measurement can be applied to determine the gestational age of fetus.
High-speed visible light communication systems based on Si-substrate LEDs with multiple superlattice interlayers
Authors: Hu Fangchen , Chen Shouqing , Zhang Yuyi , Li Guoqiang , Zou Peng , Zhang Junwen , Shen Chao , Zhang Xiaolei , Hu Jian , Zhang Jianli , He Zhixue , Yu Shaohua , Jiang Fengyi , Chi Nan 
Published: August 2021

AbstractHigh-speed visible light communication (VLC), as a cutting-edge supplementary solution in 6G to traditional radio-frequency communication, is expected to address the tension between continuously increased demand of capacity and currently limited supply of radio-frequency spectrum resource. The main driver behind the high-speed VLC is the presence of light emitting diode (LED) which not only offers energy-efficient lighting, but also provides a cost-efficient alternative to the VLC transmitter with superior modulation potential. Particularly, the InGaN/GaN LED grown on Si substrate is a promising VLC transmitter to simultaneously realize effective communication and illumination by virtue of beyond 10-Gbps communication capacity and Watt-level output optical power. In previous parameter optimization of Si-substrate LED, the superlattice interlayer (SL), especially its period number, is reported to be the key factor to improve the lighting performance by enhancing the wall-plug efficiency, but few efforts were made to investigate the influence of SLs on VLC performance. Therefore, to optimize the VLC performance of Si-substrate LEDs, we for the first time investigated the impact of the SL period number on VLC system through experiments and theoretical derivation. The results show that more SL period number is related to higher signal-to-noise ratio (SNR) via improving the wall-plug efficiency. In addition, by using Levin-Campello bit and power loading technology, we achieved a record-breaking data rate of 3.37 Gbps over 1.2-m free-space VLC link under given optimal SL period number, which, to the best of our knowledge, is the highest data rate for a Si-substrate LED-based VLC system.
Estrogen Receptor ß in Cancer: To ß(e) or not to ß(e)?
Authors: Hwang Nicole M , Stabile Laura P 
Published: August 2021

Abstract
Estrogen receptors (ERs) are known to play an important role in the proper development of estrogen-sensitive organs, as well as in the development and progression of various types of cancer. ERα, the first ER to be discovered, has been the focus of most cancer research, especially in the context of breast cancer. However, ERβ expression also plays a significant role in cancer pathophysiology, notably its seemingly protective nature and loss of expression with oncogenesis and progression. Although ERβ exhibits antitumor activity in breast, ovarian, and prostate cancer, its expression is associated with disease progression and worse prognosis in lung cancer. The function of ERβ is complicated by the presence of multiple isoforms and single nucleotide polymorphisms, in addition to tissue-specific functions. This mini-review explores current literature on ERβ and its mechanism of action and clinical implications in breast, ovarian, prostate, and lung cancer.
Children against antibiotics misuse and antimicrobial resistance: assessing effectiveness of storytelling and picture drawing as public engagement approaches
Authors: Appiah Bernard , Anum-Hagin David , Gyansa-Luterrodt Martha , Samman Elfreda , Agyeman Franklin Konadu Addo , Appiah George , Odonkor Gloria , Ludu Julius Yaw , Osafo Josephine , Rene Antonio 
Published: August 2021

Background: Interventions delivered in schools have been found to be effective in improving knowledge of antibiotics and antimicrobial resistance (AMR) among school-aged children, particularly those in high-income countries, but the evidence is largely lacking in low- and middle-income countries. This study aimed to design, implement and assess storytelling and picture drawing as engagement approaches for improving knowledge, attitudes and beliefs about antibiotics and AMR among schoolchildren in Ghana. Methods: Two schools with a total population of 375 schoolchildren ages 11-15 years in Tema, a city in Ghana, participated in public engagement interventions involving storytelling in one school and picture drawing in another school. The interventions included eight weeks of engagement led by science teachers and a competition held in each school. For quantitative outcome-based evaluation, some schoolchildren were randomly sampled in each school. Purposive sampling was also used to select some schoolchildren in each school for qualitative outcome-based evaluation. Respondents completed identical knowledge, attitudes and beliefs questionnaires and were interviewed at two time points (before and at most a week) after key interventions to assess changes in antibiotics and AMR knowledge, attitudes and beliefs. Results: Picture drawing had more significant effects (both positive and negative) on schoolchildren’s AMR knowledge, attitudes and beliefs, whereas storytelling had a negative effect on children’s AMR knowledge and no significant impact on beliefs and attitudes. Conclusions: Our project’s findings suggest that public engagement interventions that use picture drawing and storytelling may influence the knowledge, attitudes and beliefs of schoolchildren regarding antibiotic misuse and AMR. However, modifications are required to make them more effective. These include making the storytelling effective by turning it into drama or plays.
Behavioural responses to SARS-CoV-2 antibody testing in England: REACT-2 study
Authors: Redd Rozlyn , Cooper Emily , Atchison Christina , Pereira Isabella , Hollings Polly , Cooper Tom , Millar Catriona , Ashby Deborah , Riley Steven , Darzi Ara , Barclay Wendy S. , Cooke Graham S , Elliott Paul , Donnelly Christl A. , Ward Helen 
Published: August 2021

Background: This study assesses the behavioural responses to SARS-CoV-2 antibody test results as part of the REal-time Assessment of Community Transmission-2 (REACT-2) research programme, a large community-based surveillance study of antibody prevalence in England. Methods: A follow-up survey was conducted six weeks after the SARS-CoV-2 antibody test. The follow-up survey included 4500 people with a positive result and 4039 with a negative result. Reported changes in behaviour were assessed using difference-in-differences models. A nested interview study was conducted with 40 people to explore how they thought through their behavioural decisions. Results: While respondents reduced their protective behaviours over the six weeks, we did not find evidence that positive test results changed participant behaviour trajectories in relation to the number of contacts the respondents had, for leaving the house to go to work, or for leaving the house to socialise in a personal place. The qualitative findings supported these results. Most people did not think that they had changed their behaviours because of their test results, however they did allude to some changes in their attitudes and perceptions around risk, susceptibility, and potential severity of symptoms. Conclusions: We found limited evidence that knowing your antibody status leads to behaviour change in the context of a research study. While this finding should not be generalised to widespread self-testing in other contexts, it is reassuring given the importance of large prevalence studies, and the practicalities of doing these at scale using self-testing with lateral flow immunoassay (LFIA).
NAS PÁGINAS DO MULHERIO (1981-1988): UM PANORAMA SOBRE A CRÍTICA LITERÁRIA FEMINISTA E A QUESTÃO HISTORIOGRÁFICA
Authors: Da Rocha Virgínea Novack Santos , Morais Jaísa Girardi 
Published: August 2021

Partindo-se da análise das 41 edições do jornal Mulherio, posterior Nexo - Feminismo, informação e cultura, que circulou entre 1981 e 1989, buscou-se perceber o modo como o periódico feminista aborda questões sobre literatura produzidas por mulheres e a suas participações na historiografia literária, levando-se em consideração os diversos processos de inferiorização, silenciamento, exclusão e a apagamentos que escritoras mulheres e suas literaturas são submetidas pela crítica hegemônica. Nesse sentido, foi possível perceber que há no jornal um grande interesse na recuperação de escritoras do passado e divulgação de escritoras do presente da publicação, além do interesse em discutir temas próprios à “escrita feminina”, isto é, uma crítica literária própria à literatura de mulheres. Dessa forma, a partir desses dois movimentos do próprio Mulherio foi possível recuperar e analisar situações contextuais de sua exclusão escritoras relativamente grande circulação ao seu tempo, mas ainda assim excluídas do cânone oficial das histórias literárias: Cassandra Rios, Maria Elisabete Lima Mota e Dinorath do Valle.
The accuracy of prenatal diagnosis of selective fetal growth restriction with second trimester Doppler ultrasound in monochorionic diamniotic twin pregnancies
Authors: Wang Yao , Zhang Ai , Stock Tineck , Lopriore Enrico , Oepkes Dick , Wang Qiuzhen 
Published: August 2021

Background
Selective fetal restriction growth (sFGR) is one of the common diseases of monochorionic diamniotic (MCDA) twin pregnancies, resulting in many adverse outcomes. At present, second trimester ultrasonography is widely used in the prenatal diagnosis of sFGR, but the diagnostic effectiveness is still uncertain. The aim of this study is to assess the diagnostic accuracy of second trimester Doppler ultrasound measurements for sFGR.

Methods
A retrospective study included 280 pregnant women (118 with and 162 without sFGR) with MCDA pregnancies was conducted in the fetal medicine center from Leiden University Medical Center from January 2008 to December 2013. The women participating had already undergone an ultrasound examination in the second trimester. The postnatal criteria of sFGR was a single birth weight (BW) < 3 rd percentile in a twin, or birth weight discordance (BWD)≥25% between two twins, while the BW of the smaller twin < 10th percentile. Early prenatal diagnosis of sFGR was defined as a single EFW < 3 rd percentile in a twin, or at least 2 of the following 4 parameters must be met (fetal weight of one fetus < 10th percentile, AC of one fetus <10th percentile, EFW discordance≥25%, UA pulsatility index (PI) of the smaller fetus > 95th percentile). According to the diagnosis of sFGR after birth, we evaluate diagnostic effectiveness of Doppler ultrasound in the second trimester for sFGR.

Results
Of these 280 participants, the mean age was 32.06 ± 4.76 years. About 43.9% of pregnant women were primiparas. The ability of second trimester Doppler ultrasound to accurately diagnosed sFGR is 75.4%, missed diagnosis rate and the misdiagnosis rate were 24.6% and 10.5% respectively. The ROC curve indicated that the combination of AC discordance, EFW discordance, and small fetal UA blood flow was the best diagnostic indicator of sFGR in MCDA pregnancy with the AUC was 0.882 (95%CI, 0.839–0.926).

Conclusions
Second trimester Doppler and ultrasound measurements is an effective method for early prenatal diagnosis of sFGR. The combined indicator of AC discordance, EFW discordance, and the small fetal UA blood flow reaches highest diagnostic value.
Opening the wound: Receptions and readings of Inxeba in South Africa
Authors: Levine Susan 
Published: August 2021

This reading of Inxeba (2017) foregrounds the relationship between the #RhodesMustFall and #FeesMustFall movements in South Africa with the theme of wounding as an enduring social affliction in a country caught up in the midst of redefining itself after apartheid. Overtly narrated in the telling of Inxeba (2017) is the striking, amplified distinction between tradition and modernity among isiXhosa. Indeed, the polarized reception of the film among South African audiences shone a light on the slow burn of this most enduring trope. At universities across the country, Black students called for an end to the symbols of imperialist and colonialist White domination, as well as the desire to decolonize higher education by redressing Eurocentric canons of knowledge production. On the heels of the #Fallist movements, a White director makes a film about Xhosa initiation, and folds into this story a tale of homoerotic love. Notwithstanding the film’s official entry for best foreign language film at the Oscars, multiple forms of wounding came quick and heated upon the showcasing of the film’s trailer on social media.

Film:

Inxeba (English: The Wound): 2017 South African drama

Director: John Trengove

Language: Xhosa

Cast: Niza Jay Ncoyini as Kwanda
Nakhane Touré as Xolani
Bongile Mantsai as Vija