bluuebunny/crossref_metadata_2025_split huggingface dataset:
National trends of utilization and readmission rates with intravascular ultrasound use for ST‐elevation myocardial infarction
Authors: Ya'qoub Lina , Gad Mohamed , Saad Anas M. , Elgendy Islam Y. , Mahmoud Ahmed N. 
Published: February 2021

AbstractBackgroundRandomized trials have confirmed that intravascular ultrasound (IVUS) guidance for percutaneous coronary interventions (PCI) improves long‐term clinical outcomes. However, data on real‐world utilization of IVUS in ST‐elevation myocardial infarction (STEMI) and the impact on short to mid‐term outcomes are scarce. We sought to evaluate the utilization and the readmission rates for IVUS‐guided PCI in the setting of STEMI.MethodsHospitalizations with a primary diagnosis of STEMI undergoing PCI were included from the Nationwide Readmissions Database (NRD) during 2012–2017.ResultsAmong 809,601 hospitalizations with STEMI undergoing PCI, 33,644 (4.2%) underwent IVUS‐guided PCI. IVUS use increased from 4.2% in 2012 to 5.6% in 2017 (p < .0001). After matching, in‐hospital mortality was significantly lower with IVUS use (3.9% vs. 4.6%, p < .0001). The overall readmission rates were similar in both groups. We found that readmission rates due to acute MI at 6 months (5.7% vs. 6%, p = .045) and 11 months (5.1% vs. 6.5%, p = .005) as well as the PCI and mortality rates during readmission at 11 months (2.1% vs. 3%, p = .008, and 0.7% vs. 1.4%, p = .002, respectively) were significantly lower in the IVUS group.ConclusionsThe utilization of IVUS in STEMI appears to be slowly increasing. Although overall readmission rates were similar, IVUS was associated with lower in‐hospital mortality, lower rates of readmission due to acute MI at 6 and 11 months, as well as lower PCI and mortality at 11 months. Randomized trials evaluating long‐term benefits of IVUS in STEMI are needed.
Safe and rapid radial hemostasis achieved using a novel topical hemostatic patch: Results of a first‐in‐human pilot study using hydrophobically modified polysaccharide‐chitosan
Authors: Anchan Rajeev , Venturini Joseph , Larsen Paul , Lee Linda , Fernandez Christopher , Besser Stephanie A. , Kalathiya Rohan , Paul Jonathan , Blair John , Nathan Sandeep 
Published: February 2021

AbstractBackgroundThe transradial approach (TRA) for catheter interventions decreases vascular complications and bleeding versus transfemoral approach. Reducing time to hemostasis and preventing radial artery occlusion (RAO) following TRA are important and incompletely realized aspirations.ObjectivesThis first‐in‐human study sought to evaluate the efficacy of a novel, topically applied compound (hydrophobically modified polysaccharide‐chitosan, hm‐P) plus minimal required pneumatic compression, to achieve rapid radial arterial hemostasis in post‐TRA procedures compared with de facto standards.Materials and MethodsAbout 50 adult patients undergoing 6 French diagnostic TRA procedures were prospectively enrolled. At procedure completion, a topical hm‐P impregnated patch was placed over the dermotomy and TR Band (TRB) compression was applied to the access site. This patch was used as part of a novel rapid deflation protocol with a primary outcome of time to hemostasis. Photographic and vascular ultrasound evaluation of the radial artery was performed to evaluate the procedural site.ResultsTime to hemostasis was 40.5 min (IQR: 38–50 min) with the majority of patients (n = 39, 78%) not requiring reinflation. Patients with bleeding requiring TRB reinflation were more likely to have low body weight and liver dysfunction, with absence of hypertension and LV dysfunction. The rate of RAO was 0% with predischarge radial artery patency documented in all patients using vascular ultrasound. One superficial hematoma was noted. No late bleeding events or cutaneous reactions were reported in the study follow‐up.ConclusionsTopical application of hm‐P in conjunction with pneumatic compression was safe and resulted in rapid and predictable hemostasis at the arterial puncture site.
Outcome of left main stem percutaneous coronary intervention in a UK nonsurgical center: A 5‐year clinical experience
Authors: Alaour Bashir , Onwordi Eunice , Khan Asif , Menexi Christina , Carta Sabrina , Strike Philip , Griffiths Huw , Anantharam Brijesh , Hobson Alexander , Dana Ali 
Published: February 2021

AbstractObjectivesTo evaluate the outcome of unprotected left main stem (LMS) percutaneous coronary intervention (PCI) in a large UK nonsurgical center.BackgroundPCI on unprotected LMS is increasingly regarded as a viable alternative to coronary artery bypass grafting (CABG) with comparable outcome and safety profile in select groups. The safety and efficacy of unprotected LMS PCI without on‐site surgical back up has not been reported.MethodsData on all unprotected LMS PCI performed between January 2011 and December 2015, was collected from the local PCI database and electronic patient records. In hospital and 1‐year major adverse cardiovascular events (MACE) (all‐cause mortality, myocardial infarction [MI], stroke, and target vessel revascularization [TVR]) was recorded.Results249 patients had unprotected LMS intervention during the study period. 77% of patients (n = 192) were male and mean age was 70 ± 12 years. 31% (n = 78) of cases were elective, 44% (n = 109) NSTEMI, and 25% (n = 62) STEMI. Anatomical distribution: 19% (n = 47) ostial left main, 31% (n = 77) shaft, and 50% (n = 125) bifurcation. The mean SYNTAX score was 24.4 ± 10.6. 22% (n = 55) of patients had severe LV impairment preprocedure and 13% (n = 33) were in cardiogenic shock at presentation. 35% (14%) required IABP support. The vast majority (98.4%) of procedures were successful. No patients required emergency transfer for CABG surgery. There were 25 (10%) in‐hospital deaths. 68% of in‐hospital deaths occurred in patients undergoing primary PCI for STEMI. 72% of patients who died were in cardiogenic shock at presentation. The 12‐month MACE rate was 17.2%. Death occurred in 11.6%, MI in 2.4%, TVR in 2.4%, and stroke in 0.8% of patients.ConclusionThese results highlight the safety and efficacy of unprotected LMS PCI in a high volume non‐surgical center.
Successful impella‐assisted suction thrombectomy of right heart thrombus via the AngioVac device: Advantages, limitations, and alternatives
Authors: Shadman Shahrad , Heyliger Stephen , Watts Carolyn , Aghili Nima 
Published: February 2021

AbstractAn elderly man with cardiogenic shock who was found to have a thrombus burden in the right atrium was described. The thrombus was suctioned via the AngioVac device, with assistance from the Impella CP. This is the first reported case of the use of the AngioVac device in conjunction with left‐sided mechanical circulatory devices.
Deferring stent optimization in stent thrombosis: A novel approach for STEMI management—Insights from a case series
Authors: Cioffi Giacomo Maria , Madanchi Mehdi , Bossard Matthias , Cuculi Florim 
Published: February 2021

AbstractTreatment of ST represents a challenge. The presence of large amounts of thrombus combined with stent optimization increase the risk of distal embolization. A two‐step strategy of stent implantation and deferred stent optimization might be appropriated. We hereby present three clinical cases of ST successfully treated with a two‐step approach.
Diagnosis, management, and recovery from COVID‐19: A case report from bangladesh
Authors: Akther Lutfa , Shahnewaz Shaila Sharmin , Ferdous Dilruba , Pramanik Md. Moyen Uddin 
Published: February 2021

AbstractThere is no known medicine for COVID‐19, and thus, the clinical management is symptomatic. More than 80% people experience mild symptoms who can be treated at home for fever, sore throat, and cough. About 15% patients develop severe illness require O2.
Tailoring NIV by dynamic laryngoscopy in a child with spinal muscular atrophy type I
Authors: Vollsæter Maria , Skjoldmo Anett , Røksund Ola , Hilland Magnus , Andersen Tiina 
Published: February 2021

AbstractDynamic laryngoscopy during noninvasive (NIV) respiratory therapy is feasible and may facilitate optimal and individualized treatment in patients with chronic respiratory failure, also in children.
CPX‐351 (Vyxeos®) can cause severe rash in acute myeloid leukemia—A case report
Authors: Urbantat Ruth M. , Popper Valentin , Menschel Elisabeth , Pfeilstöcker Michael , Forjan Ernst , Nader Alexander , Sieghart Catherine R. , Keil Felix , Koller Elisabeth 
Published: February 2021

AbstractCPX‐351, a promising new agent for patients with treatment‐related and secondary acute myeloid leukemia can lead to a severe whole‐body rash. Although severe side effects are rare, treatment should be carefully monitored at specialized centers.
Nephronophthisis and central veins abnormalities: A case report
Authors: Rahil Mohamed Amine , Hadjmhamed Messaoud 
Published: February 2021

AbstractPatients with genetic disorders are potentially more susceptible to present vascular abnormalities compared to the general population. For these patients, unusual difficulties could appear during a CVC placement procedure that could lead to major complications if venous abnormalities are undiagnosed. Ultrasound and fluoroscopy guidance should be used routinely for all patients in order to avoid complications and catheter misplacement.
Schwannoma of the brachial plexus with cystic degeneration: A case report schwannoma of the brachial plexus
Authors: Aleksanyan Lusine V. , Afyan Tigran S. , Khachatryan Parandzem S. , Poghosyan Anna Yu 
Published: February 2021

AbstractSchwannoma of the brachial plexus can be present as a painless swelling without an upper limb functional or sensitivity deficiency. Thorough examinations, including MRI, are necessary to identify the nerves of origin and prevent potential harm.
Cerebellar amelanotic melanoma can mimic cerebellar abscess in a pediatric case of neurocutaneous melanosis
Authors: Mormina Enricomaria , Vinci Sergio Lucio , Coglitore Alessandra , Visalli Carmela , Tessitore Agostino , Cavallaro Marco , Galletta Karol , Granata Francesca 
Published: February 2021

AbstractNeurocutaneous melanosis (NCM) is a rare phakomatosis that may be associated with intracerebral masses. The differential diagnosis of intracerebral masses in NCM is often challenging and should include pigmented and nonpigmented lesions.
The effect of monoethylene glycol on the stability of water‐in‐oil emulsions
Authors: Queiroz Danielle G. , da Silva Carla M. F. , Minale Mario , Merino Daniel , Lucas Elizabete F. 
Published: February 2021

AbstractIt is important from both a strategic and economic standpoint to study the mechanism of formation of water/oil emulsions, to predict their increase of viscosity with respect to that of the crude oil, and to obtain information about the stability vs separation of these substances (since their presence can impair oil processing and distribution). The objective of this work was to ascertain the influence of monoethylene glycol (MEG) on these parameters and its action mechanism. The addition of MEG in different proportions in the oil emulsions significantly changed the flow curve of the emulsion, passing from a quasi‐Newtonian one to a shear thinning behaviour. Besides this, when MEG was present at low concentrations, the demulsification process was slow and an increase in concentration made the emulsions more stable than samples containing the same aqueous phase proportion. Under the conditions studied, the addition of MEG did not reduce the quantity of the aqueous phase separated compared to the emulsions free of MEG, but significantly delayed the demulsification process. Rheology provided important information regarding the phase separation process of the aqueous phase in oil phase emulsions, and dynamic testing suggested that the most relevant effect of the addition of MEG is an increase of the emulsion elasticity that can be correlated with the increase in the emulsion stability observed by bottle test and Turbiscan.
Could open science stimulate industry partnerships in chemical engineering university research?
Authors: Hart Kirsten , An Sung , Edwards Aled M. , Mahadevan Radhakrishnan , Master Emma R. , Edwards Elizabeth A. 
Published: February 2021

AbstractOpen science means sharing all information in the research process as early as possible and making the output available without restriction on use. In the most expansive definition of open science, this includes sharing early‐stage inventions that could be the subject of patent applications. We illustrate how this expansive open science definition has attracted pharmaceutical companies to partner with universities to tackle big problems in biomedicine. We propose that by applying this framework to engineering, it will also encourage industry to work collaboratively with researchers in academia to tackle some of our big problems: climate change, energy sustainability, food security, and water quality and quantity. However, there are misgivings or misconceptions about adopting open science in engineering. This article explores some of the barriers to open science in academia in general, and specifically as applied to university‐based research in chemical engineering.
Scalable spatio‐temporal Bayesian analysis of high‐dimensional electroencephalography data
Authors: Mohammed Shariq , Dey Dipak K. 
Published: February 2021

AbstractWe present a scalable Bayesian modelling approach for identifying brain regions that respond to a certain stimulus and use them to classify subjects. More specifically, we deal with multi‐subject electroencephalography (EEG) data with a binary response distinguishing between alcoholic and control groups. The covariates are matrix‐variate with measurements taken from each subject at different locations across multiple time points. EEG data have a complex structure with both spatial and temporal attributes. We use a divide‐and‐conquer strategy and build separate local models, that is, one model at each time point. We employ Bayesian variable selection approaches using a structured continuous spike‐and‐slab prior to identify the locations that respond to a certain stimulus. We incorporate the spatio‐temporal structure through a Kronecker product of the spatial and temporal correlation matrices. We develop a highly scalable estimation algorithm, using likelihood approximation, to deal with large number of parameters in the model. Variable selection is done via clustering of the locations based on their duration of activation. We use scoring rules to evaluate the prediction performance. Simulation studies demonstrate the efficiency of our scalable algorithm in terms of estimation and fast computation. We present results using our scalable approach on a case study of multi‐subject EEG data.
Textile color formulation using linear programming based on Kubelka‐Munk and Duncan theories
Authors: Moussa Ali 
Published: February 2021

AbstractIn this article, a new approach based on linear programming optimization is proposed to solve the textile color formulation problem. The principle aims to find the appropriate dyes to mix and their exact concentrations, which, when applied correctly, produce the required color. Two ranges of reactive dyes were used for dyeing cotton fabrics. The objective function and all the constraints of the model are expressed linearly according to the decision variables. The objective function is to minimize the differences between the K/S spectra of the sample dyed with the proposed mixture and the target color. The constraints of the model are formulated based on Kubelka‐Munk and Duncan theories in the same way as those of the single‐constant model. The relevance of the method developed using linear programming optimization was evaluated and proven by calculating errors between the proposed and actual recipes, errors in K/S spectra, and Colour Measurement Committee CMC(2:1) differences between the reproduced and target colors. The proposed program showed very good results with very small values of errors and color differences.
A predictive replication for multi‐tenant databases using deep learning
Authors: Abdel Raouf Ahmed E. , Abo‐alian Alshaimaa , Badr Nagwa L. 
Published: February 2021

AbstractThe service level agreement (SLA) is an agreement between clients and the service provider, which defines the minimum performance and availability requirements for software. The service provider should have effective strategies for placement, migration, and replication of the tenants to reduce their operational costs, maximize the utilization of their hardware and software resources and accordingly meet the SLA requirements with slight SLA violations. In this research, a clustered‐based multi‐tenant database management system (CB‐MT DBMS) is proposed. Additionally, a dynamic proactive provisioning technique is built using three different prediction models: The Recursive Window Forecasting Autoregressive Integrated Moving Average (ARIMA) model, Exponential Moving Average (EMA) model, and the proposed Recurrent Neural Network (RNN) with Long Short‐Term Memory (LSTM) cells model. Various experimental scenarios with different datasets have been conducted to prove that the RNN model with LSTM cells is a promising solution in multi‐tenant environments, where the tenants have irregular workload patterns. Experimental results firstly show that the RNN model accuracy is superior to their counterparts (i.e., ARIMA and EMA models) when applied to multi‐tenant database workloads generated using TPC benchmarks, as it reduces the prediction error value which is computed using the Mean Absolute Percentage Error (MAPE) and the Root Mean Square Error (RMSE) metrics. Secondly, Experimental results prove that the RNN prediction model accuracy is superior to their counterparts for detecting SLA violation values and windows using different SLA values.
Flow Cytometric Evaluation of the Ongoing Angiogenic Response in Rat Cardiac Tissue Following Myocardial Infarction
Authors: Hoeeg Cecilie , Ringgaard Lars , Christensen Esben , Follin Bjarke , Bentsen Simon , Ripa Rasmus Sejersten , Kjaer Andreas 
Published: February 2021

AbstractAngiogenesis is involved in regeneration of cardiac tissue following acute myocardial infarction (MI), a disease often investigated in rat models. Therefore, the ability to thoroughly evaluate the angiogenic response following experimentally induced MI in rats, and distinguish it from inflammation, is desired. This would enable evaluation of the angiogenic potential of new therapeutics and improve knowledge on MI pathophysiology. Due to the complex response to MI involving multiple cell types and the limited selection of rat‐specific antibodies, careful optimization is crucial to capture this complexity. Here, we present an 8‐color flow cytometry‐based multicolor panel that will enable quantification of the ongoing angiogenic response as well as characterize the cells involved. A detailed description of tissue preparation, immunostaining, and gating strategy is provided. © 2021 Wiley Periodicals LLC.This article was corrected on 26 July 2022. See the end of the full text for details.Basic Protocol: Cardiac tissue preparation and staining to investigate the ongoing angiogenic response in rat cardiac tissue following myocardial infarctionSupport Protocol: Titration of all antibodies in the presented panel
Effect of Sodium Sulfate on Nucleation Behavior and the Crystal Morphology of Taurine
Authors: Wu Di , Zhang Bei , Luo Weijia , Zhu Huaxiang , Xu Jun , Zhou Lina , Hou Baohong , Chen Wei 
Published: February 2021

AbstractTwo theoretical methods, self‐consistent Nývlt‐like approach and Sangwal's classical 3D nucleation theory‐based method, are employed to analyze the effects of additives (sodium sulfate) on the nucleation behavior of taurine. By correlating the measured metastable zone width of taurine containing different sodium sulfate concentrations, with saturation temperature and cooling rate, nucleation kinetic parameters in both two methods are determined. Fitting results demonstrate that higher sodium sulfate concentration results in the increase of solid–liquid interfacial energy γ, contrarily higher saturation temperature has the opposite effect thus changing of nucleation rate. The molecular modeling techniques are then applied to investigate the changes in the morphology of taurine which caused by the presence of sodium sulfate. Through molecular dynamic simulations, the interaction energy of sodium sulfate with taurine crystal faces are obviously larger than those of taurine and these differences on the (011) and (11‐1) are more significant than those on (021) and (111) faces. As a result, the growth of (011) and (11‐1) faces is inhibited and the morphology of taurine crystal is modified from needle to columnar. The influence of sodium sulfate on taurine studied in this work provides theoretical guidance for industrial production.
A novel wireless underground transceiver for landslide internal parameter monitoring based on magnetic induction
Authors: Wang Honghui , Zhuo Tianxiang , Zhong Pan , Wei Chaoyu , Zou Dingkang , Zhong Yunshun 
Published: February 2021

SummaryThis article introduces a magnetic induction communication transceiver MI‐S125‐III, which can be buried in a landslide body and can be used to transmit the internal characteristic parameters of landslide mass (such as inclination angle). The device is based on the Manchester code, and the working frequency is 125 kHz. Its data transmission distance can reach 5.28 m in the soil. We built a physical landslide model, in which three MI‐S125‐III nodes with a tilting sensor were embedded, and the angle monitoring curve was obtained by human triggering. The angle monitoring curve can reflect the sliding process, indicating that MI‐S125‐III can be used for landslide monitoring and early warning in the future.
The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disorders
Authors: Chong Wai Chin , Shastri Madhur D , Peterson Gregory M , Patel Rahul P , Pathinayake Prabuddha S , Dua Kamal , Hansbro Nicole G , Hsu Alan C , Wark Peter A , Shukla Shakti Dhar , Johansen Matt D , Schroder Kate , Hansbro Philip M 
Published: February 2021

AbstractInflammation is the result of a complex network of cellular and molecular interactions and mechanisms that facilitate immune protection against intrinsic and extrinsic stimuli, particularly pathogens, to maintain homeostasis and promote tissue healing. However, dysregulation in the immune system elicits excess/abnormal inflammation resulting in unintended tissue damage and causes major inflammatory diseases including asthma, chronic obstructive pulmonary disease, atherosclerosis, inflammatory bowel diseases, sarcoidosis and rheumatoid arthritis. It is now widely accepted that both endoplasmic reticulum (ER) stress and inflammasomes play critical roles in activating inflammatory signalling cascades. Notably, evidence is mounting for the involvement of ER stress in exacerbating inflammasome‐induced inflammatory cascades, which may provide a new axis for therapeutic targeting in a range of inflammatory disorders. Here, we comprehensively review the roles, mechanisms and interactions of both ER stress and inflammasomes, as well as their interconnected relationships in inflammatory signalling cascades. We also discuss novel therapeutic strategies that are being developed to treat ER stress‐ and inflammasome‐related inflammatory disorders.