bluuebunny/crossref_metadata_2025_split huggingface dataset:
Avoidance of milk and dairy products after oral surgery—is such a recommendation still valid? A cross-sectional study among German and international oral and maxillofacial surgeons and dental practitioners with review of the literature
Authors: Seyedi Moghaddam Schiwa , Neff Andreas 
Published: October 2021

Abstract
Purpose
For prevention of wound-healing complications, patients in German-speaking countries are traditionally advised to avoid consumption of milk and dairy products after oral surgery. In the absence of national and international guidelines, this study investigates scientific evidence and compares international practice, frequency scale, and rationale behind such recommendation.

Methods
Comparison of a German cross-sectional mono-center-questionnaire pilot study and a survey among international oral and maxillofacial surgeons (OMFS), specialized oral surgeons and general dentists, evaluating international practice regarding post-operative dietary and nutrition recommendations. Our literature review further assessed scientific evidence for relevant effects of probiotics, prebiotics, and/or synbiotics.

Results
Among German study participants, 56% (n = 64/114) advise patients to avoid milk and dairy products, with 42% of OMFS (n = 38) and 65% (n = 76) of the general dentists recommending abstention (p = .027). In striking contrast, such recommendation could not be identified in our international survey (n = 143) (t test, p < .001) nor in the literature. There were significant differences between German and international study participants regarding the rationale for dietary recommendations, with dental schools and literature most frequently indicated as sources (Fisher’s exact test, p < .001).

Conclusion
The hypothesis of a harmful effect of the consumption of milk and dairy products after dentoalveolar surgery could not be supported by evidence. The recommendation to avoid dairy products post-surgery was identified as a specific phenomenon practiced almost exclusively in German-speaking countries. Corresponding recommendations, most probably based on a now irrelevant risk of contracting tuberculosis from milk products, can at present no longer be substantiated.
Vulnerability Factors among Women Victimized by Intimate Partner Violence and the Presence of Children
Authors: Petersson Joakim , Thunberg Sara 
Published: October 2021

AbstractThis study aimed to a) examine the presence of children in relation to victim vulnerability factors and assessed risk for intimate partner violence (IPV) re-victimization, and b) examine the police response, in terms of risk management, in IPV cases with and without children, respectively. Data from a sample of 1407 women who had reported IPV victimization to the Swedish police was analyzed. The material consisted of risk assessments conducted by the police using the Swedish version of the Brief Spousal Assault Form for the Evaluation of Risk (B-SAFER) checklist, as well as the recommended risk management strategies. A series of chi-square tests of independence revealed that women with and without children, respectively, displayed different vulnerability factors to different extents. Women with children expressed more extreme fear of the perpetrator and were more likely to have an unsafe living situation, whereas women without children displayed more inconsistent attitudes or behaviors and health problems. However, binary logistic regression analyses showed that the victim vulnerability factors that were most strongly associated with an elevated risk rating for IPV re-victimization were generally the same for both groups of victims. Finally, the presence of children was related to a higher risk rating for imminent IPV re-victimization and to recommendations of more than standard levels of risk management strategies. The results indicate that the Swedish police consider the presence of children in relation to a victim’s risk for re-victimization as well as in terms of recommended risk management strategies.
Optimizing Adaptive Notifications in Mobile Health Interventions Systems: Reinforcement Learning from a Data-driven Behavioral Simulator
Authors: Wang Shihan , Zhang Chao , Kröse Ben , van Hoof Herke 
Published: October 2021

AbstractMobile health (mHealth) intervention systems can employ adaptive strategies to interact with users. Instead of designing such complex strategies manually, reinforcement learning (RL) can be used to adaptively optimize intervention strategies concerning the user’s context. In this paper, we focus on the issue of overwhelming interactions when learning a good adaptive strategy for the user in RL-based mHealth intervention agents. We present a data-driven approach integrating psychological insights and knowledge of historical data. It allows RL agents to optimize the strategy of delivering context-aware notifications from empirical data when counterfactual information (user responses when receiving notifications) is missing. Our approach also considers a constraint on the frequency of notifications, which reduces the interaction burden for users. We evaluated our approach in several simulation scenarios using real large-scale running data. The results indicate that our RL agent can deliver notifications in a manner that realizes a higher behavioral impact than context-blind strategies.
What drives low-carbon agriculture? The experience of farms from the Wielkopolska region in Poland
Authors: Borychowski Michał , Grzelak Aleksander , Popławski Łukasz 
Published: October 2021

AbstractBecause of global environmental problems, low-carbon agriculture has gained increasing importance both in developed and developing countries. Hence, there is a need to find ways to develop more efficient agricultural systems. The purpose of this article is to identify the drivers of low-carbon agriculture on farms in the Wielkopolska region (in Poland). We aimed to take an original approach to investigate low-carbon agriculture with a unique set of different economic and environmental variables and contribute to the literature, which is not very extensive in terms of microeconomic research, including research on farmers in the Wielkopolska region. Therefore, we employed a multiple-factor measurement model for structural equation modeling (SEM) of data collected individually from 120 farms in 2020. As a result, we formulated the following conclusions: the increasing productivity of factors (land, labor, and capital) have a positive effect on low-carbon farming, just as increasing fertilizer and energy efficiency. Moreover, thermal insulation is also important for low-carbon agriculture, with efficiency of fertilizer use being the most important factor. We believe that the issues of farm use of fertilizers and thermal insulation of buildings should be more broadly included in energy policy, both at the national and the European Union (EU) levels. Some of these factors however are already present in the common agricultural policy (CAP) for 2021–2027.
The outbreak of COVID-19 in Taiwan in late spring 2021: combinations of specific weather conditions and related factors
Authors: Chang Shih-An , Kuan Chia-Hsuan , Hung Chi-Yen , Wang Tai-Chi Chen , Chen Yu-Sheng 
Published: October 2021

AbstractThis study aimed to investigate the impact of weather conditions on the daily incidence of the COVID-19 pandemic in late spring 2021 in Taiwan, which is unlike the weather conditions of the COVID-19 outbreak in 2020. Meteorological parameters such as maximum daily temperature, relative humidity, and wind speed were included. The Spearman rank correlation test was used to evaluate the relationship between weather and daily domestic COVID-19 cases. The maximum daily temperature had a positively significant correlation with daily new COVID-19 cases within a 14-day lag period, while the relative humidity and wind speed has a fairly high correlation with the number of daily cases within a 13- and 14-day lag, respectively. In addition, the weather characteristics during this period were an increasingly high temperature, with steady high relative humidity and slightly decreasing wind speed. Our study revealed the weather conditions at the time of the domestic outbreak of COVID-19 in Taiwan in May 2021 and the possible association between weather factors and the COVID-19 pandemic. Further large-scale analysis of weather factors is essential for understanding the impact of weather on the spread of infectious diseases.
Drugs and Bugs: The Gut-Brain Axis and Substance Use Disorders
Authors: Simpson Sierra , Mclellan Rio , Wellmeyer Emma , Matalon Frederic , George Olivier 
Published: October 2021

AbstractSubstance use disorders (SUDs) represent a significant public health crisis. Worldwide, 5.4% of the global disease burden is attributed to SUDs and alcohol use, and many more use psychoactive substances recreationally. Often associated with comorbidities, SUDs result in changes to both brain function and physiological responses. Mounting evidence calls for a precision approach for the treatment and diagnosis of SUDs, and the gut microbiome is emerging as a contributor to such disorders. Over the last few centuries, modern lifestyles, diets, and medical care have altered the health of the microbes that live in and on our bodies; as we develop, our diets and lifestyle dictate which microbes flourish and which microbes vanish. An increase in antibiotic treatments, with many antibiotic interventions occurring early in life during the microbiome's normal development, transforms developing microbial communities. Links have been made between the microbiome and SUDs, and the microbiome and conditions that are often comorbid with SUDs such as anxiety, depression, pain, and stress. A better understanding of the mechanisms influencing behavioral changes and drug use is critical in developing novel treatments for SUDSs. Targeting the microbiome as a therapeutic and diagnostic tool is a promising avenue of exploration. This review will provide an overview of the role of the gut-brain axis in a wide range of SUDs, discuss host and microbe pathways that mediate changes in the brain’s response to drugs, and the microbes and related metabolites that impact behavior and health within the gut-brain axis.
Graphic Abstract
Die Adhärenz Erwachsener an der Bewegungsaufzeichnung über 7 Tage mittels Akzelerometer
Authors: Ulbricht Sabina , Siewert-Markus Ulrike , Ullrich Antje , Voigt Lisa , John Ulrich 
Published: October 2021

Zusammenfassung
Hintergrund
Über den Einsatz direkter Messmethoden zur Erfassung körperlicher Aktivität bei Erwachsenen in Deutschland ist bislang wenig bekannt.

Ziel
Ziel der Studie ist die Beschreibung der Adhärenz und die Analyse individueller Determinanten, ein Akzelerometer über 7 Tage zu tragen.

Material und Methoden
In einem Einkaufszentrum wurden 365 Personen (40 bis 75 Jahre) für eine 7‑tägige Aufzeichnung ihrer körperlichen Aktivität gewonnen. Von diesen hatten 231 (63,3 %) das Gerät täglich mindestens 10 h getragen.

Ergebnisse
Teilnehmende in Partnerschaft trugen das Akzelerometer mit höherer Wahrscheinlichkeit entsprechend der Anweisung verglichen mit jenen ohne Partnerschaft. Schlechtere subjektive Gesundheit war mit einer geringeren Einhaltung der Anweisungen das Akzelerometer zu tragen assoziiert.

Diskussion
Um möglichst valide Daten über Umfang und Intensität körperlicher Aktivität zu erhalten, sollten Menschen ohne Partner und solche mit schlechterer subjektiver Gesundheit über den Tragezeitraum des Gerätes hinweg motiviert werden, es regelmäßig zu tragen.
Evaluation eines hochschulinternen Fitnessstudios und die Auswirkungen auf die Lebensqualität von Trainierenden – eine Querschnittsstudie
Authors: Griefahn Annika , Twellmann Thomas , Yalcin Leon , Zalpour Christoff 
Published: October 2021

Zusammenfassung
Hintergrund
Präventive Maßnahmen werden im Rahmen der Gesundheitsförderung immer bedeutsamer. Die regelmäßige Bewegung führt u. a. zu einer Stärkung des Herz-Kreislauf-Systems sowie zur Reduktion von muskuloskelettalen Beschwerden. Angestellte von Hochschulen sowie Studierende leiden häufig unter muskuloskelettalen Beschwerden.

Ziel
Ziel der Kundenbefragung ist es, die Zufriedenheit mit dem hochschulinternen Fitnessstudio INMOVE abzufragen, das rein physiotherapeutisch konzipiert ist. Mithilfe des Fragebogens sollen v. a. die Bereiche der Zufriedenheit, der physiotherapeutischen Betreuung sowie die subjektive Lebensqualität beurteilt werden.

Methode
Es wurde eine Kundenbefragung mit 26 Fragen, welche in vier Abschnitte eingeteilt sind, durchgeführt. Die geschlossenen Fragen wurden deskriptiv ausgewertet und die acht offenen Fragen wurden mit der Kernsatzmethode nach Leithäuser und Volmerg (1988) ausgewertet.

Ergebnisse
An der Befragung nahmen insgesamt 70 Trainierende (weiblich: 22/31,2 %, männlich: 48/68,8 %) teil. Anhand der Ergebnisse zeigt sich, dass die Teilnehmenden die Frage „Inwieweit sind die Kunden des hier genannten INMOVE mit dem Fitnessstudio zufrieden?“ mit „ziemlich zutreffend“ und „zutreffend“ beantworteten. Die zweite Forschungsfrage „Ist die physiotherapeutische Betreuung adäquat für das Fitnessstudio?“ kann mit „ziemlich zutreffend“ beantwortet werden. Die dritte Forschungsfrage bezog sich auf die Verbesserung der subjektiven Lebensqualität. Die Antwortenverteilung spiegelt, dass die Teilnehmenden diesen Themenbereich mit überwiegend „trifft genau zu“ oder „trifft ziemlich zu“ beantworteten.

Schlussfolgerung
Anhand der Kundenbefragung konnte die Zufriedenheit sowie die Auswirkungen auf die subjektive Lebensqualität beurteilt werden. Es lässt sich aus den Ergebnissen ableiten, dass ein hochschulinternes Fitnessstudio dabei helfen kann, Alltagsstress abzubauen und somit präventiv bei muskuloskelettalen Beschwerden nützlich ist.
The Role of PPAR-γ in Allergic Disease
Authors: Stark Julian M. , Coquet Jonathan M. , Tibbitt Christopher A. 
Published: October 2021

Abstract
Purpose of Review
The incidence of allergic diseases such as asthma, rhinitis and atopic dermatitis has risen at an alarming rate over the last century. Thus, there is a clear need to understand the critical factors that drive such pathologic immune responses. Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a nuclear receptor that has emerged as an important regulator of multiple cell types involved in the inflammatory response to allergens; from airway epithelial cells to T Helper (TH) cells.

Recent Findings
Initial studies suggested that agonists of PPAR-γ could be employed to temper allergic inflammation, suppressing pro-inflammatory gene expression programs in epithelial cells. Several lines of work now suggest that PPAR-γ plays an essential in promoting ‘type 2’ immune responses that are typically associated with allergic disease. PPAR-γ has been found to promote the functions of TH2 cells, type 2 innate lymphoid cells, M2 macrophages and dendritic cells, regulating lipid metabolism and directly inducing effector gene expression. Moreover, preclinical models of allergy in gene-targeted mice have increasingly implicated PPAR-γ in driving allergic inflammation.

Summary
Herein, we highlight the contrasting roles of PPAR-γ in allergic inflammation and hypothesize that the availability of environmental ligands for PPAR-γ may be at the heart of the rise in allergic diseases worldwide.
Diagnostic Challenges in Sepsis
Authors: Duncan Chris F. , Youngstein Taryn , Kirrane Marianne D. , Lonsdale Dagan O. 
Published: October 2021

Abstract
Purpose of Review
Sepsis is a leading cause of death worldwide. Groundbreaking international collaborative efforts have culminated in the widely accepted surviving sepsis guidelines, with iterative improvements in management strategies and definitions providing important advances in care for patients. Key to the diagnosis of sepsis is identification of infection, and whilst the diagnostic criteria for sepsis is now clear, the diagnosis of infection remains a challenge and there is often discordance between clinician assessments for infection.

Recent Findings
We review the utility of common biochemical, microbiological and radiological tools employed by clinicians to diagnose infection and explore the difficulty of making a diagnosis of infection in severe inflammatory states through illustrative case reports. Finally, we discuss some of the novel and emerging approaches in diagnosis of infection and sepsis.

Summary
While prompt diagnosis and treatment of sepsis is essential to improve outcomes in sepsis, there remains no single tool to reliably identify or exclude infection. This contributes to unnecessary antimicrobial use that is harmful to individuals and populations. There is therefore a pressing need for novel solutions. Machine learning approaches using multiple diagnostic and clinical inputs may offer a potential solution but as yet these approaches remain experimental.
Investigating the effects of COVID-19 lockdown on Italian children and adolescents with and without neurodevelopmental disorders: a cross-sectional study
Authors: Termine Cristiano , Dui Linda Greta , Borzaga Laura , Galli Vera , Lipari Rossella , Vergani Marta , Berlusconi Valentina , Agosti Massimo , Lunardini Francesca , Ferrante Simona 
Published: October 2021

AbstractWe conducted a cross-sectional study to compare the impact of social distancing and lifestyle changes that occurred during Corona Virus Disease 2019 (COVID-19) lockdown on children and adolescents with and without Neurodevelopmental Disorders (NDDs). An online questionnaire was administered in order to investigate the effects of NDD condition, socio-demographic status, familiar/home environment and COVID-19 exposure on their lives during a two months period of social isolation. We used logistic regression, focusing on five endpoints (remote learning, lifestyle, stress/anxiety, sociality, scolding) to define the extent of these effects. Most questions were paired up to parents and children, to verify the occurrence of agreement. 8305 questionnaires were analyzed, 1362 of which completed by NDDs and 6943 by controls. Results showed that the presence of a NDD, compared to controls, had a significant impact on: Remote Learning (i.e. subjects with NDDs experienced more difficulties in attending online classes and studying), Sociality (i.e. subjects with NDDs missed their schoolmates less), Scolding (i.e. subjects with NDDs were scolded more often) and Anxiety (i.e. subjects with NDDs were perceived by their parents as more anxious). Substantial agreement between parents and children arose from questions concerning Remote learning, Lifestyle and Scolding. The current study actually points out that having a NDD gives account for a stronger influence on school performance and on behavioral and psychological aspects, during a two months lockdown. Such results may provide useful information to governments and school authorities on how carrying through supportive strategies for youth affected by NDDs.
Re-assessment of ammonoid specimens from the Early Carboniferous Protocanites Beds of the Badenweiler–Lenzkirch Zone (Schwarzwald, Central Variscan Belt): age constraints for a lithostratigraphic key bed
Authors: Korn Dieter , Montenari Michael 
Published: October 2021

AbstractTheProtocanitesBeds of the Black Forest Massif (Germany) form an important lithostratigraphic key bed, as the index fossils contained in this formation enable correlation within large areas of the internal zone of the central Variscan Belt of Europe. Furthermore, the formation provides significant information on the geodynamic evolution of the Moldanubian Zone. The stratigraphic age of the formation has been a subject of controversy in the past; a Devonian to Viséan age has been proposed. To determine the age of theProtocanitesBeds, two ammonoid specimens from theProtocanitesBeds of Schönau are re-described here. They belong toBecanites abnobensisandPericylcus princepsand fix the stratigraphic position of theProtocanitesBeds to the early Late Tournaisian.
Influence of processing steps on the fate of ochratoxin A, patulin, and alternariol during production of cloudy and clear apple juices
Authors: Aroud Husam Ibrahem , May Bianca , Dietrich Helmut , Schweiggert Ralf , Kemmlein Sabine 
Published: October 2021

AbstractMycotoxins are frequently found in fruits and fruit juices. However, data about occurrence and fate of mycotoxins along the fruit juice processing chain are currently insufficient. Herein, a liquid chromatographic/tandem mass spectrometric (LC–MS/MS) multi-mycotoxin method was developed and applied to investigate the effect of technological unit operations on the fate of three of the most relevant mycotoxins along the processing chain for cloudy and clear apple juice, namely patulin (PAT), ochratoxin A (OTA), and alternariol (AOH). Raw juice obtained directly after dejuicing was spiked with the aforementioned mycotoxins at pilot-plant scale prior to subjecting it to different technological unit operations. Regarding clear apple juice production treatment with a pectinolytic enzyme preparation, and pasteurization were insignificant for mycotoxin reduction, but fining with subsequent filtration was effective, although the mycotoxins showed different affinity towards the tested agents. The most effective fining agent was activated charcoal/bentonite in combination with ultrafiltration, which removed OTA (54 µg/L) and AOH (79 µg/L) to not quantifiable amounts (limit of quantification (LOQ) 1.4 and 4.6 µg/L, respectively), while PAT was reduced only by 20% (from 396 to 318 µg/L). Regarding cloudy apple juice production, all studied processing steps such as centrifugation and pasteurization were ineffective in reducing mycotoxin levels. In brief, none of the common steps of clear and cloudy apple juice production represented a fully effective safety step for minimizing or even eliminating common mycotoxins. Thus, ensuring the sole use of sound apples should be of utmost importance for processors, particularly for those manufacturing cloudy juices.
Liquid biopsies in epilepsy: biomarkers for etiology, diagnosis, prognosis, and therapeutics
Authors: Whitlock Jordan H. , Soelter Tabea M. , Williams Avery S. , Hardigan Andrew A. , Lasseigne Brittany N. 
Published: October 2021

AbstractEpilepsy is one of the most common diseases of the central nervous system, impacting nearly 50 million people around the world. Heterogeneous in nature, epilepsy presents in children and adults alike. Currently, surgery is one treatment approach that can completely cure epilepsy. However, not all individuals are eligible for surgical procedures or have successful outcomes. In addition to surgical approaches, antiepileptic drugs (AEDs) have also allowed individuals with epilepsy to achieve freedom from seizures. Others have found treatment through nonpharmacologic approaches such as vagus nerve stimulation, or responsive neurostimulation. Difficulty in accessing samples of human brain tissue along with advances in sequencing technology have driven researchers to investigate sampling liquid biopsies in blood, serum, plasma, and cerebrospinal fluid within the context of epilepsy. Liquid biopsies provide minimal or non-invasive sample collection approaches and can be assayed relatively easily across multiple time points, unlike tissue-based sampling. Various efforts have investigated circulating nucleic acids from these samples including microRNAs, cell-free DNA, transfer RNAs, and long non-coding RNAs. Here, we review nucleic acid-based liquid biopsies in epilepsy to improve understanding of etiology, diagnosis, prediction, and therapeutic monitoring.