bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolomic Profiles and Heart Failure Risk in Black Adults: Insights From the Jackson Heart Study
Authors: Tahir Usman A. , Katz Daniel H. , Zhao Tianyi , Ngo Debby , Cruz Daniel E. , Robbins Jeremy M. , Chen Zsu-Zsu , Peterson Bennet , Benson Mark D. , Shi Xu , Dailey Lucas , Andersson Charlotte , Vasan Ramachandran S. , Gao Yan , Shen Changyu , Correa Adolfo , Hall Michael E. , Wang Thomas J. , Clish Clary B. , Wilson James G. , Gerszten Robert E. 
Published: January 2021

Background:
Heart failure (HF) is a heterogeneous disease characterized by significant metabolic disturbances; however, the breadth of metabolic dysfunction before the onset of overt disease is not well understood. The purpose of this study was to determine the association of circulating metabolites with incident HF to uncover novel metabolic pathways to disease.

Methods:
We performed targeted plasma metabolomic profiling in a deeply phenotyped group of Black adults from the JHS (Jackson Heart Study; n=2199). We related metabolites associated with incident HF to established etiological mechanisms, including increased left ventricular mass index and incident coronary heart disease. Furthermore, we evaluated differential associations of metabolites with HF with preserved ejection fraction versus HF with reduced ejection fraction.

Results:

Metabolites associated with incident HF included products of posttranscriptional modifications of RNA, as well as polyamine and nitric oxide metabolism. A subset of metabolite-HF associations was independent of well-established HF pathways such as increased left ventricular mass index and incident coronary heart disease and included homoarginine (per 1 SD increase in metabolite level, hazard ratio, 0.77;
P
=1.2×10
−3
), diacetylspermine (hazard ratio, 1.34;
P
=3.4×10
−3
), and uridine (hazard ratio, 0.79;
P
, 3×10
−4
). Furthermore, metabolites involved in pyrimidine metabolism (orotic acid) and collagen turnover (
N
-methylproline) among others were part of a distinct metabolic signature that differentiated individuals with HF with preserved ejection fraction versus HF with reduced ejection fraction.

Conclusions:
The integration of clinical phenotyping with plasma metabolomic profiling uncovered novel metabolic processes in nontraditional disease pathways underlying the heterogeneity of HF development in Black adults.
Defining Shock and Preshock for Mortality Risk Stratification in Cardiac Intensive Care Unit Patients
Authors: Jentzer Jacob C. , Burstein Barry , Van Diepen Sean , Murphy Joseph , Holmes David R. , Bell Malcolm R. , Barsness Gregory W. , Henry Timothy D. , Menon Venu , Rihal Charanjit S. , Naidu Srihari S. , Baran David A. 
Published: January 2021

Background:
Previous studies have defined preshock as isolated hypotension or isolated hypoperfusion, whereas shock has been variably defined as hypoperfusion with or without hypotension. We aimed to evaluate the mortality risk associated with hypotension and hypoperfusion at the time of admission in a cardiac intensive care unit population.

Methods:
We analyzed Mayo Clinic cardiac intensive care unit patients admitted between 2007 and 2015. Hypotension was defined as systolic blood pressure <90 mm Hg or mean arterial pressure <60 mm Hg, and hypoperfusion as admission lactate >2 mmol/L, oliguria, or rising creatinine. Associations between hypotension and hypoperfusion with hospital mortality were estimated using multivariable logistic regression.

Results:

Among 10 004 patients with a median age of 69 years, 43.1% had acute coronary syndrome, and 46.1% had heart failure. Isolated hypotension was present in 16.7%, isolated hypoperfusion in 15.3%, and 8.7% had both hypotension and hypoperfusion. Stepwise increases in hospital mortality were observed with hypotension and hypoperfusion compared with neither hypotension nor hypoperfusion (3.3%; all
P
<0.001): isolated hypotension, 9.3% (adjusted odds ratio, 1.7 [95% CI, 1.4–2.2]); isolated hypoperfusion, 17.2% (adjusted odds ratio, 2.3 [95% CI, 1.9–3.0]); both hypotension and hypoperfusion, 33.8% (adjusted odds ratio, 2.8 [95% CI, 2.1–3.6]). Adjusted hospital mortality in patients with isolated hypoperfusion was higher than in patients with isolated hypotension (
P
=0.02) and not significant different from patients with both hypotension and hypoperfusion (
P
=0.18).

Conclusions:
Hypotension and hypoperfusion are both associated with increased mortality in cardiac intensive care unit patients. Hospital mortality is higher with isolated hypoperfusion or concomitant hypotension and hypoperfusion (classic shock). We contend that preshock should refer to isolated hypotension without hypoperfusion, while patients with hypoperfusion can be considered to have shock, irrespective of blood pressure.
Dressing like the Great King: Amerindian Perspectives on Persian Fashion in Classical Athens
Authors: Olson S. Douglas 
Published: January 2021

Abstract
This paper examines the phenomenon of individual Athenians adopting elements of Persian clothing, making use of exotic items such as gold and silver drinking vessels, and the like, by comparison to what I argue is a similar sort of contact and exchange involving the European fabric trade and evolving standards of dress and fashion in the Early Modern Atlantic. The ancient literary and archaeological sources discussed document the reaction of a relatively insignificant, marginal people (the Greeks) to the dress practices of a more powerful and arguably far more sophisticated imperial power (the Persians). I suggest that an appreciation of the character and intentions of the much better documented encounter between the English court and Amerindian ambassadors who visited it in the early 18th century provides a potentially useful corrective to the indigenous perspective of our Athenian sources.
Punishment, Stigma and Social Identities in Classical Athens
Authors: Kucharski Janek 
Published: January 2021

Abstract
Taking its cue from modern debates on the expressive function of punishment, this paper discusses the stigmatizing effect of penalties in classical Athens. It focuses on corporal punishment, which was discursively associated in the Athenian public discourse (chiefly comedy and oratory) with slaves and other fringe groups of the citizen community, despite the fact that in reality, with only certain restrictions (e.g. whipping), it was meted out to all social tiers making up the polis-community. Unlike other penalties, those affecting the body were not only public, but not infrequently spectacular. This turned them into versatile devices of stigmatization whereby the punishment itself was no longer considered a one-off event, but a permanent mark branding the person who suffered it as a social outcast.
Functional dyeable polypropylene fabric development and process parameter optimization Part I: Dyeable modified polypropylene development with process parameter optimization
Authors: Kuo Chung-Feng Jeffrey , Chen Shih Hsiung 
Published: January 2021

This study aims to develop dyeable modified polypropylene (PP) granules with disperse dye. The optimal dyeable modified PP granule process used polyester as a mixed copolymer. The purpose was to overcome the excessive difference between the polyester material melting point and PP melting point. The development of a low-melting modified co-polybutylene adipate terephthalate (Co-PBAT) was the key point. After the low-melting modified Co-PBAT was presented, PP and a PP grafting maleic anhydride compatibilizer were made into a composite by dual-screw mixing process. The disperse dye dyeability was reached by the molecular behavior of the Co-PBAT chain segment. The prepared material was applied to explore the thermal properties of modified ester pellets and the functional group was verified by Fourier infrared spectroscopy. In this study, the Taguchi method and principal component analysis were used to optimize the process parameter design of two quality characteristics; namely, the color strength and the polymer melt flow index (MFI). According to the results, the multi-quality optimization of the ester pellets consisted of a modified Co-PBAT melting point of 170°C, the modified Co-PBAT content of 9 wt%, the compatibilizer content of 3 wt%, and the mixing temperature of 205°C. The MFI of the regular PP polymer was 28.1 g/10 min, the color strength was 100 K/S. For the optimal process, the MFI of the PP/Co-PBAT dyeable granules was 37.88 g/10 min, and the color strength was 121.31 K/S. It could be observed that the developed polymer had good circulating workability and color strength.
Analysis of drug resistance and mutation profiles in Mycobacterium tuberculosis isolates in a surveillance site in Beijing, China
Authors: Zhang Jie , Ren Yixuan , Pan Liping , Yi Junli , Guan Tong , Yang Xinyu , Zhang Zongde 
Published: January 2021

Objective This study analyzed drug resistance and mutations profiles in Mycobacterium tuberculosis isolates in a surveillance site in Huairou District, Beijing, China. Methods The proportion method was used to assess drug resistance profiles for four first-line and seven second-line anti-tuberculosis (TB) drugs. Molecular line probe assays were used for the rapid detection of resistance to rifampicin (RIF) and isoniazid (INH). Results Among 235 strains of M. tuberculosis, 79 (33.6%) isolates were resistant to one or more drugs. The isolates included 18 monoresistant (7.7%), 19 polyresistant (8.1%), 28 RIF-resistant (11.9%), 24 multidrug-resistant (MDR) (10.2%), 7 pre-extensively drug-resistant (XDR, 3.0%), and 2 XDR strains (0.9%). A higher rate of MDR-TB was detected among previously treated patients than among patients with newly diagnosed TB (34.5% vs. 6.8%). The majority (62.5%) of RIF-resistant isolates exhibited a mutation at S531L in the DNA-dependent RNA polymerase gene. Meanwhile, 62.9% of INH-resistant isolates carried a mutation at S315T1 in the katG gene. Conclusion Our results confirmed the high rate of drug-resistant TB, especially MDR-TB, in Huairou District, Beijing, China. Therefore, detailed drug testing is crucial in the evaluation of MDR-TB treatment.
Incidence and treatment of feline renal lymphoma: 27 cases
Authors: Williams Ashlyn G , Hohenhaus Ann E , Lamb Kenneth E 
Published: January 2021

Objectives Lymphoma is the most common feline hematopoietic malignancy. Incidence of renal lymphoma has not been reported as a subset of a large population of feline lymphoma cases. Previous studies have reported renal lymphoma as both a singular entity as well as a component of multicentric disease. The clinical presentation, diagnostic evaluation, therapy and outcomes related to renal lymphoma have not been reported since Mooney et al in 1987. This retrospective study aimed to describe the incidence of renal lymphoma, clinical signs, treatment and survival. Methods Using a database of cats diagnosed with lymphoma between January 2008 and October 2017, cats with renal lymphoma were selected for further analysis. Cases were retrospectively staged according to Mooney et al (1987) and Gabor et al (1998). Data collected included age, clinical signs, clinicopathologic data, diagnostic imaging findings, lymphoma diagnostic method(s), treatment protocol(s) and survival time. Analyses comparing median survival based on therapy administered, renal lymphoma vs multicentric lymphoma, central nervous system involvement, presence of azotemia, anemia and International Renal Interest Society (IRIS) stage at diagnosis were performed. Results From a population of 740 cats with lymphoma, 27 cats had renal lymphoma (incidence, 3.6%), and 14 of those cats had multicentric lymphoma. Fewer stage IV and V cases were identified in this data set compared with Mooney et al; however, not all cats were completely staged. Median survival (range) for cats receiving corticosteroids alone compared with those receiving an L-CHOP (L-asparaginase, vincristine, cyclophosphamide, doxorubicin, prednisolone)-based protocol was 50 days (20–1027 days) in the corticosteroid group and 203 days (44–2364 days) for the L-CHOP group ( P = 0.753) for cats that died secondary to lymphoma. Conclusions and relevance Neither clinical stage nor other factors were predictive of survival. Prospective studies are required to determine the optimal chemotherapy protocol.
Microbiology, Histopathology, and Radiographic Findings in Silent Sinus Syndrome
Authors: Zheng Henry D. , Mecham Jeffrey C. , Abdel-Aty Yassmeen , Lal Devyani , Marino Michael J. 
Published: January 2021

Background The histopathology and microbiology associated with silent sinus syndrome (SSS) have not been well described. Objective This study details the histopathological and microbiological characteristics in addition to radiographic findings of SSS in comparison to those of chronic maxillary sinusitis (CRS). Methods 42 patients diagnosed with SSS at Mayo Clinic Hospital in Arizona were identified. Paranasal computed tomography scans of the 42 SSS patients as well as 42 matched CRS patients were analyzed in order to assess differences in the prevalence of septal spurs/deviation. 20 of the SSS patients and 19 of the matched CRS patients also had histopathology and microbiology reports, which were compiled and summarized. Additionally, 19 SSS and 19 matched CRS patients were contacted via phone survey for a more complete patient history regarding maxillary dental disease/surgery. Results SSS patients have a significantly higher prevalence of septal spurs/deviation than CRS patients. The microbiomes of SSS patients more closely resemble those of healthy controls than those of CRS patients. Analysis of the histopathology of SSS reveals chronic, non-specific inflammation similar to that seen in non-eosinophilic CRS without polyps. SSS patients were significantly more likely to have a history of maxillary dental disease requiring surgery. Conclusion These data support the hypothesis that the pathogenesis of SSS is more likely due to anatomical/mechanical factors than inflammatory/microbiological factors.
Revision Anterior Cervical Disc Arthroplasty: A National Analysis of the Associated Indications, Procedures, and Postoperative Outcomes
Authors: Lee Nathan J. , Joaquim Andrei F. , Boddapati Venkat , Mathew Justin , Park Paul , Kim Jun S. , Sardar Zeeshan M. , Lehman Ronald A. , Riew K. Daniel 
Published: January 2021

Study Design: Retrospective study. Objective: To examine the associated indications, procedures, and postoperative outcomes after revision ACDA. Methods: We utilized a national database to identify adult(≥18 years) patients who underwent either a primary ACDA or removal of ACDA over a 10-year period(2008-2017). An in-depth assessment of the reasons for revision surgery and the subsequent procedures performed after the removal of ACDA was done by using both Current Procedural Terminology(CPT) and International Statistical Classification of Diseases (ICD-9,10) coding. Results: From 2008 to 2017, a total of 3,350 elective, primary ACDA cases were performed. During this time, 69 patients had a revision surgery requiring the removal of ACDA. The most common reasons for revision surgery included cervical spondylosis(59.4%) and mechanical complications(27.5%). After removal of ACDA, common procedures performed included anterior cervical fusion with or without decompression(69.6%), combined anterior/posterior fusion/decompression (11.6%), and replacement of ACDA (7.2%). The indications for surgery did not vary significantly among the different procedures performed (p = 0.318). Patients requiring revision surgery for mechanical complications or those who underwent a combined surgical approach were at significantly higher risk for subsequent short-term complications (p<0.05). Conclusion: Over a 10-year period, the rate of revision surgery for ACDA was low (2.1%). Nearly 90% of revision cases were due to either cervical spondylosis or mechanical complications. These indications for surgery did not vary significantly among the different procedures performed. These findings will be important during the shared-decision making process for patients undergoing primary or revision ACDA.
A Literature Review on Impact of COVID-19 Pandemic on Teaching and Learning
Authors: Pokhrel Sumitra , Chhetri Roshan 
Published: January 2021

The COVID-19 pandemic has created the largest disruption of education systems in human history, affecting nearly 1.6 billion learners in more than 200 countries. Closures of schools, institutions and other learning spaces have impacted more than 94% of the world’s student population. This has brought far-reaching changes in all aspects of our lives. Social distancing and restrictive movement policies have significantly disturbed traditional educational practices. Reopening of schools after relaxation of restriction is another challenge with many new standard operating procedures put in place. Within a short span of the COVID-19 pandemic, many researchers have shared their works on teaching and learning in different ways. Several schools, colleges and universities have discontinued face-to-face teachings. There is a fear of losing 2020 academic year or even more in the coming future. The need of the hour is to innovate and implement alternative educational system and assessment strategies. The COVID-19 pandemic has provided us with an opportunity to pave the way for introducing digital learning. This article aims to provide a comprehensive report on the impact of the COVID-19 pandemic on online teaching and learning of various papers and indicate the way forward.
Syndecan-1 and stromal heparan sulfate proteoglycans: key moderators of plasma cell biology and myeloma pathogenesis
Authors: Ren Zemin , Spaargaren Marcel , Pals Steven T. 
Published: January 2021

AbstractPlasma cells no longer express a B-cell antigen receptor and are hence deprived of signals crucial for survival throughout B-cell development. Instead, normal plasma cells, as well as their malignant myeloma counterparts, heavily rely on communication with the bone marrow (BM) microenvironment for survival. The plasma cell heparan sulfate proteoglycan (HSPG) syndecan-1 (CD138) and HSPGs in the BM microenvironment act as master regulators of this communication by co-opting specific growth and survival factors from the BM niche. This designates syndecan-1/HSPGs and their synthesis machinery as potential treatment targets in multiple myeloma.
Modeling and targeting of erythroleukemia by hematopoietic genome editing
Authors: Iacobucci Ilaria , Qu Chunxu , Varotto Elena , Janke Laura J. , Yang Xu , Seth Aman , Shelat Anang , Friske Jake D. , Fukano Reiji , Yu Jiyang , Freeman Burgess B. , Kennedy James A. , Sperling Adam S. , Zheng Rena , Wang Yingzhe , Jogiraju Harini , Dickerson Kirsten M. , Payne-Turner Debbie , Morris Sarah M. , Hollis Emily S. , Ghosn Nina , Haggard Georgia E. , Lindsley R. Coleman , Ebert Benjamin L. , Mullighan Charles G. 
Published: January 2021

Abstract
Acute erythroid leukemia (AEL) is characterized by a distinct morphology, mutational spectrum, lack of preclinical models, and poor prognosis. Here, using multiplexed genome editing of mouse hematopoietic stem and progenitor cells and transplant assays, we developed preclinical models of AEL and non-erythroid acute leukemia and describe the central role of mutational cooperativity in determining leukemia lineage. Different combination of mutations in Trp53, Bcor, Dnmt3a, Rb1, and Nfix resulted in the development of leukemia with an erythroid phenotype, accompanied by the acquisition of alterations in signaling and transcription factor genes that recapitulate human AEL by cross-species genomic analysis. Clonal expansion during tumor evolution was driven by mutational cooccurrence, with clones harboring a higher number of founder and secondary lesions (eg, mutations in signaling genes) showing greater evolutionary fitness. Mouse and human AEL exhibited deregulation of genes regulating erythroid development, notably Gata1, Klf1, and Nfe2, driven by the interaction of mutations of the epigenetic modifiers Dnmt3a and Tet2 that perturbed methylation and thus expression of lineage-specific transcription factors. The established mouse leukemias were used as a platform for drug screening. Drug sensitivity was associated with the leukemia genotype, with the poly (ADP-ribose) polymerase inhibitor talazoparib and the demethylating agent decitabine efficacious in Trp53/Bcor–mutant AEL, CDK7/9 inhibitors in Trp53/Bcor/Dnmt3a–mutant AEL, and gemcitabine and bromodomain inhibitors in NUP98-KDM5A leukemia. In conclusion, combinatorial genome editing has shown the interplay of founding and secondary genetic alterations in phenotype and clonal evolution, epigenetic regulation of lineage-specific transcription factors, and therapeutic tractability in erythroid leukemogenesis.
Variable blood processing procedures contribute to plasma proteomic variability
Authors: Halvey Patrick , Farutin Victor , Koppes Laura , Gunay Nur Sibel , Pappas Dimitrios A. , Manning Anthony M. , Capila Ishan 
Published: January 2021

AbstractBackgroundPlasma is a potentially rich source of protein biomarkers for disease progression and drug response. Large multi-center studies are often carried out to increase the number of samples analyzed in a given study. This may increase the chances of variation in blood processing and handling, leading to altered proteomic results. This study evaluates the impact of blood processing variation on LC–MS/MS proteomic analysis of plasma.MethodsInitially two batches of patient plasma samples (120 and 204 samples, respectively) were analyzed using LC–MS/MS shotgun proteomics. Follow-up experiments were designed and carried out on healthy donor blood in order to examine the effects of different centrifugation conditions, length of delay until first centrifugation, storage temperature and anticoagulant type on results from shotgun proteomics.ResultsVariable levels of intracellular proteins were observed in subsets of patient plasma samples from the initial batches analyzed. This observation correlated strongly with the site of collection, implicating variability in blood processing procedures. Results from the healthy donor blood analysis did not demonstrate a significant impact of centrifugation conditions to plasma proteome variation. The time delay until first centrifugation had a major impact on variability, while storage temperature and anticoagulant showed less pronounced but still significant effects. The intracellular proteins associated with study site effect in patient plasma samples were significantly altered by delayed processing also.ConclusionsVariable blood processing procedures contribute significantly to plasma proteomic variation and may give rise to increased intracellular proteins in plasma. Accounting for these effects can be important both at study design and data analysis stages. This understanding will be valuable to incorporate in the planning of protein-based biomarker discovery efforts in the future.