bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association analysis of juvenile idiopathic arthritis genetic susceptibility factors in Estonian patients
Authors: Nikopensius Tiit , Niibo Priit , Haller Toomas , Jagomägi Triin , Voog-Oras Ülle , Tõnisson Neeme , Metspalu Andres , Saag Mare , Pruunsild Chris 
Published: June 2021

Abstract
Background
Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic condition of childhood. Genetic association studies have revealed several JIA susceptibility loci with the strongest effect size observed in the human leukocyte antigen (HLA) region. Genome-wide association studies have augmented the number of JIA-associated loci, particularly for non-HLA genes. The aim of this study was to identify new associations at non-HLA loci predisposing to the risk of JIA development in Estonian patients.

Methods
We performed genome-wide association analyses in an entire JIA case–control sample (All-JIA) and in a case–control sample for oligoarticular JIA, the most prevalent JIA subtype. The entire cohort was genotyped using the Illumina HumanOmniExpress BeadChip arrays. After imputation, 16,583,468 variants were analyzed in 263 cases and 6956 controls.

Results
We demonstrated nominal evidence of association for 12 novel non-HLA loci not previously implicated in JIA predisposition. We replicated known JIA associations in CLEC16A and VCTN1 regions in the oligoarticular JIA sample. The strongest associations in the All-JIA analysis were identified at PRKG1 (P = 2,54 × 10−6), LTBP1 (P = 9,45 × 10−6), and ELMO1 (P = 1,05 × 10−5). In the oligoarticular JIA analysis, the strongest associations were identified at NFIA (P = 5,05 × 10−6), LTBP1 (P = 9,95 × 10−6), MX1 (P = 1,65 × 10−5), and CD200R1 (P = 2,59 × 10−5).

Conclusion
This study increases the number of known JIA risk loci and provides additional evidence for the existence of overlapping genetic risk loci between JIA and other autoimmune diseases, particularly rheumatoid arthritis. The reported loci are involved in molecular pathways of immunological relevance and likely represent genomic regions that confer susceptibility to JIA in Estonian patients.

Key Points• Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease with heterogeneous presentation and genetic predisposition.• Present genome-wide association study for Estonian JIA patients is first of its kind in Northern and Northeastern Europe.• The results of the present study increase the knowledge about JIA risk loci replicating some previously described associations, so adding weight to their relevance and describing novel loci.• The study provides additional evidence for the existence of overlapping genetic risk loci between JIA and other autoimmune diseases, particularly rheumatoid arthritis.
A Multilevel Approach to Understanding the Determinants of Maternal Harsh Parenting: the Importance of Maternal Age and Perceived Partner Support
Authors: Farley Laura , Oliver Bonamy R. , Pike Alison 
Published: June 2021

AbstractDeterminants of parenting are most often considered using one child per family within a cross-sectional design. In 182 families, the current study included two siblings and sought to predict maternal harsh parenting measured prospectively when each child was age 2 years from child gender, infant temperament, maternal age, maternal educational attainment, maternal depression and anxiety and maternal perceptions of partner support. Multilevel modeling was used to examine between- and within-family variance simultaneously. Mothers reported levels of harsh parenting that were similar towards both children (intraclass correlation = 0.69). Thus, the majority of variance in maternal perceptions of their harsh parenting resided between rather than within families and was accounted for in part by maternal age and maternal perceptions of partner support. Results are discussed in relation to family-wide determinants of harsh parenting, previous literature pertaining to parenting siblings and the potential avenues for future research and practice.
Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition: the DOSANCO Health Study
Authors: Shimizu Yu , Nakamura Kiminori , Kikuchi Mani , Ukawa Shigekazu , Nakamura Koshi , Okada Emiko , Imae Akihiro , Nakagawa Takafumi , Yamamura Ryodai , Tamakoshi Akiko , Ayabe Tokiyoshi 
Published: June 2021

AbstractRecently, aging is considered a risk factor for various diseases. Although changes in the intestinal microbiota along with aging are thought to associate with the increased disease risk, mechanisms that cause age-related transition of the intestinal microbiota remain unknown. This study aims to clarify relationships between the amount of human defensin 5 (HD5), a Paneth cell α-defensin, which is known to regulate the intestinal microbiota, and age-related differences of the intestinal microbiota composition. Fecal samples from 196 healthy Japanese (35 to 81 years old) were collected and measured HD5 concentration. HD5 concentration in the elderly group (age > 70 years old) was significantly lower than the middle-aged group (age ≤ 70 years old). Furthermore, individual age was negatively correlated with HD5 concentration (r =  − 0.307, p < 0.001). In β-diversity, the intestinal microbiota of the elderly showed a significantly different composition compared to the middle-aged. At the genus level, relative abundance of Collinsella, Alistipes, Peptococcaceae; unassigned, Lactobacillus, Lactococcus, Weissella, Christensenellaceae R-7 group, Megasphaera, and [Eubacterium] eligens group was significantly higher, and Lachnospiraceae; unassigned, Blautia, Anaerostipes, Fusicatenibacter, Dorea, and Faecalibacterium was significantly lower in the elderly compared to the middle-aged. In addition, HD5 concentration was negatively correlated with Alistipes, Peptococcaceae; unassigned, and Christensenellaceae R-7 group and positively correlated with Lachnospiraceae; unassigned and Dorea. These results provide novel insights into the immunosenescence of enteric innate immunity, indicating low HD5 is suggested to contribute to the age-related differences in the intestinal microbiota and may relate to increased risk of diseases in elderly people.
Conventional displays of structures in data compared with interactive projection-based clustering (IPBC)
Authors: Thrun Michael C. , Pape Felix , Ultsch Alfred 
Published: June 2021

AbstractClustering is an important task in knowledge discovery with the goal to identify structures of similar data points in a dataset. Here, the focus lies on methods that use a human-in-the-loop, i.e., incorporate user decisions into the clustering process through 2D and 3D displays of the structures in the data. Some of these interactive approaches fall into the category of visual analytics and emphasize the power of such displays to identify the structures interactively in various types of datasets or to verify the results of clustering algorithms. This work presents a new method called interactive projection-based clustering (IPBC). IPBC is an open-source and parameter-free method using a human-in-the-loop for an interactive 2.5D display and identification of structures in data based on the user’s choice of a dimensionality reduction method. The IPBC approach is systematically compared with accessible visual analytics methods for the display and identification of cluster structures using twelve clustering benchmark datasets and one additional natural dataset. Qualitative comparison of 2D, 2.5D and 3D displays of structures and empirical evaluation of the identified cluster structures show that IPBC outperforms comparable methods. Additionally, IPBC assists in identifying structures previously unknown to domain experts in an application.
WomBot: an exploratory robot for monitoring wombat burrows
Authors: Ross Robert , Carver Scott , Browne Elizabeth , Thai Ba Son 
Published: June 2021

Abstract
In this study we evaluate the design and efficacy of Wombot, an exploratory robot used to study environmental conditions within wombat burrows. Our purpose-built robot traverses through the difficult terrain present in wombat burrows whilst facilitating placement and retrieval of environmental data loggers. Our preliminary results suggest that the environmental conditions present within the burrows would result in a long mite survival time which shows significant risk for spreading infestations throughout a wombat population.

Article Highlights

Wombats live in difficult to observe burrows and suffer from mange cased by Sarcoptes scabiei.

A teleoperated robot was designed to traverse the difficult terrain within burrows whilst placing and retrieving environmental loggers.

Cool and humid environmental conditions within burrows suggest a relatively long mite survival time of 16–18 days
Engaging faculty in a workshop intervention on overcoming the influence of implicit bias
Authors: Carnes Molly , Sheridan Jennifer , Fine Eve , Lee You-Geon , Filut Amarette , Topp Sharon 
Published: June 2021

Abstract

Introduction:
To study the effectiveness of any educational intervention for faculty requires first that they attend the training. Using attendance as a measure of faculty engagement, this study examined factors associated with the percentage of faculty in divisions of departments of medicine who attended a workshop as part of a multisite study.

Methods:
Between October 2018 and March 2020, 1675 of 4767 faculty in 120 divisions of 14 departments of medicine attended a 3-hour in-person workshop as part of the Bias Reduction in Internal Medicine (BRIM) initiative. This paper describes the workshop development and study design. The number of faculty per division ranged from 5 to 296. Attendance rates varied from 2.7% to 90.1%. Taking a quality improvement approach, the study team brainstormed factors potentially related to variations in workshop attendance, constructed several division- and institution-level variables, and assessed the significance of factors on workshop attendance with hierarchical linear models.

Results:
The following were positively associated with workshop attendance rate: the division head attended the workshop, the BRIM principal investigator gave Medical Grand Rounds, and the percentage of local workshop presenters who completed training. Workshop attendance rates fell when departments identified more than five on-site study leaders.

Conclusions:
Factors associated with higher workshop attendance may have increased the perceived status and value of attending the workshop, leading faculty to choose the workshop over other competing demands. For future investigators studying educational interventions that require participation of faculty in clinical departments at multiple sites, this work offers several valuable lessons.
POWER SERIES PROOFS FOR LOCAL STABILITIES OF KÄHLER AND BALANCED STRUCTURES WITH MILD -LEMMA
Authors: RAO SHENG , WAN XUEYUAN , ZHAO QUANTING 
Published: June 2021

AbstractBy use of a natural map introduced recently by the first and third authors from the space of pure-type complex differential forms on a complex manifold to the corresponding one on the small differentiable deformation of this manifold, we will give a power series proof for Kodaira–Spencer’s local stability theorem of Kähler structures. We also obtain two new local stability theorems, one of balanced structures on an n-dimensional balanced manifold with the
$(n-1,n)$
th mild
$\partial \overline {\partial }$
-lemma by power series method and the other one on p-Kähler structures with the deformation invariance of
$(p,p)$
-Bott–Chern numbers.
ACQUIRING L2 PRONOUN INTERPRETATION BIASES
Authors: Contemori Carla , Mossman Sabrina , Ramos Alba K. 
Published: June 2021

AbstractLearners of a nonnull subject language (e.g., English) whose first language (L1) is a null subject language (e.g., Spanish) can show some optionality in the interpretation of overt subject pronouns in the second language (L2). By exposing L2 learners to nativelike interpretations of pronouns in discourse, we aim at understanding how exposure can promote implicit learning of pronoun comprehension biases in a L2. A sentence comprehension task was used with intermediate-proficiency English L2 speakers (L1 Spanish) that included a pretest, an exposure phase using the priming technique, an immediate posttest, and a delayed posttest administered 6–10 days later. English learners showed a significant increase in nativelike pronoun interpretations both in the immediate posttest and in the delayed posttest, in comparison to the pretest. The results show that exposure through priming can be effective in changing L2 participants’ interpretations and that effects of exposure are persistent and may aid in the successful acquisition of pronoun resolution biases.
First glaciological investigations at Ridge B, central East Antarctica
Authors: Ekaykin Alexey A. , Bolshunov Alexey V. , Lipenkov Vladimir Ya. , Scheinert Mirko , Eberlein Lutz , Brovkov Evgeniy , Popov Sergey V. , Turkeev Alexey V. 
Published: June 2021

AbstractThe region of Ridge B in central East Antarctica is one of the last unexplored parts of the continent and, at the same time, ranks among the most promising places to search for Earth's oldest ice. In January 2020, we carried out the first scientific traverse from Russia's Vostok Station to the topographical dome of Ridge B (Dome B, 3807 m above sea level, 79.02°S, 93.69°E). The glaciological programme included continuous snow-radar profiling and geodetic positioning along the traverse's route, installation of snow stakes, measurements of snow density, collection of samples for stable water isotope and chemical analyses and drilling of a 20 m firn core. The first results of the traverse show that the surface mass balance at Dome B (2.28 g cm−2 year−1) is among the lowest in Antarctica. The firn temperature below the layer of annual variations is −58.1 ± 0.2°C. A very low value of heavy water stable isotope content (-58.2‰ for oxygen-18) was discovered at a distance of 170 km from Vostok Station. This work is the first step towards a comprehensive reconnaissance study of the Ridge B area aimed at locating the best site for future deep drilling for the oldest Antarctic ice.
The gut microbiota as a therapeutic target for obesity: a scoping review
Authors: Santos-Paulo Stephanie , Costello Samuel P. , Forster Samuel C. , Travis Simon P. , Bryant Robert V. 
Published: June 2021

AbstractThere is mounting evidence that microbiome composition is intimately and dynamically connected with host energy balance and metabolism. The gut microbiome is emerging as a novel target for counteracting the chronically positive energy balance in obesity, a disease of pandemic scale which contributes to >70 % of premature deaths. This scoping review explores the potential for therapeutic modulation of gut microbiota as a means of prevention and/or treatment of obesity and obesity-associated metabolic disorders. The evidence base for interventional approaches which have been shown to affect the composition and function of the intestinal microbiome is summarised, including dietary strategies, oral probiotic treatment, faecal microbiota transplantation and bariatric surgery. Evidence in this field is still largely derived from preclinical rodent models, but interventional studies in obese populations have demonstrated metabolic improvements effected by microbiome-modulating treatments such as faecal microbiota transplantation, as well as drawing attention to the unappreciated role of microbiome modulation in well-established anti-obesity interventions, such as dietary change or bariatric surgery. The complex relationship between microbiome composition and host metabolism will take time to unravel, but microbiome modulation is likely to provide a novel strategy in the limited armamentarium of effective treatments for obesity.
Heart rate variability moderates the effects of COVID-19-related stress and family adversity on emotional problems in adolescents: Testing models of differential susceptibility and diathesis stress
Authors: Miller Jonas G. , Chahal Rajpreet , Kirshenbaum Jaclyn S. , Ho Tiffany C. , Gifuni Anthony J. , Gotlib Ian H. 
Published: June 2021

AbstractThe COVID-19 pandemic is a unique period of stress, uncertainty, and adversity that will have significant implications for adolescent mental health. Nevertheless, stress and adversity related to COVID-19 may be more consequential for some adolescents’ mental health than for others. We examined whether heart rate variability (HRV) indicated differential susceptibility to mental health difficulties associated with COVID-19 stress and COVID-19 family adversity. Approximately 4 years prior to the pandemic, we assessed resting HRV and HRV reactivity to a well-validated stress paradigm in 87 adolescents. During the pandemic, these adolescents (ages 13–19) reported on their health-related stress and concerns about COVID-19, family adversity related to COVID-19, and their recent emotional problems. The association between COVID-19 stress and emotional problems was significantly stronger for adolescents who previously exhibited higher resting HRV or higher HRV reactivity. For adolescents who exhibited lower resting HRV or HRV augmentation, COVID-19 stress was not associated with emotional problems. Conversely, lower resting HRV indicated vulnerability to the effect of COVID-19 family adversity on emotional problems. Different patterns of parasympathetic functioning may reflect differential susceptibility to the effects of COVID-19 stress versus vulnerability to the effects of COVID-19 family adversity on mental health during the pandemic.
The endangered Brown Shrike subspecies Lanius cristatus superciliosus has a male-biased sex ratio and only early arriving males are paired
Authors: MIZUMURA HARUKA , KUBOTA KOHEI , HIGUCHI HIROYOSHI 
Published: June 2021

SummaryAlong with many long-distance migrant passerine species in the East Asian-Australasian Flyway, the migratory Brown Shrike Lanius cristatus superciliosus has been sharply declining throughout its breeding range. Its breeding range in Japan shrank by 90.9% between the 1910s and 2010s. In contrast, the closely related but resident Bull-headed Shrike L. bucephalus bucephalus has been gradually declining but is still a common resident in Japan. To better understand the drastic decline of Brown Shrike, we compared the pairing success during three consecutive breeding seasons of these two species. About 60–70% of Brown Shrike males were unpaired, which was much higher than the percentage of unpaired male Bull-headed Shrike (c.0–20%). Brown Shrike males arriving later did not pair because the population’s sex proportion is heavily biased toward males. One of the factors of male-biased population of Brown Shrike may be female-biased mortality in wintering sites, or on the migratory journey, and tracking studies will be required to test this.
Palliative care and aggressive interventions after falling: A Nationwide Inpatient Sample analysis
Authors: Ho Vanessa P. , Bensken Wyatt P. , Koroukian Siran M. 
Published: June 2021

AbstractObjectiveThe purpose of this study is to identify whether there is an opportunity for improvement to provide palliative care services after a serious fall. We hypothesized that (1) palliative care services would be utilized in less than 10% of patients over the age of 65 who fall and (2) more than 20% of patients would receive aggressive life-sustaining treatments (LSTs) prior to death.MethodsUsing the 2017 Nationwide Inpatient Sample, we identified patients who were admitted to the hospital with a fall (ICD-10 W00-W19) and were hospitalized at least two days with valid discharge data. Palliative care services (Z51.5) or LSTs (cardiopulmonary resuscitation, ventilation, reintubation, tracheostomy, feeding tube placement, vasopressors, transfusion, total parenteral nutrition, and hemodialysis) were identified with ICD-10 codes. We examined the use of palliative care or LSTs by discharge destination (home, facility, and death). Logistic regression was used to identify factors associated with palliative care.ResultsIn total, 155,241 patients were identified (median 82 years old, interquartile range 74–88); 2.5% died in hospital, and 69.4% were transferred to a facility. Palliative care occurred in 4.5% of patients, and LST occurred in 15.1%. Patients who died were significantly more likely to have had palliative care (50.1% vs. 3.4% of home or facility discharges) and were more likely to have an LST [53.0% vs. 9.8% (home) vs. 15.9% (facility)]. Palliative care was associated with both death [adjusted odds ratio (AOR) 19.84, 95% confidence interval (CI) 18.39–21.41, p < 0.001] and LST (AOR 1.36, 95% CI 1.27–1.46, p < 0.001).Significance of resultsPalliative care is associated with both death and LST, suggesting that physicians use palliative care as a last resort after aggressive measures have been exhausted. Patients who fall would likely benefit from the early use of palliative care to align future goals of care.
Interaction of contact herbicides and timing of dicamba exposure on soybean
Authors: Castner Mason C. , Norsworthy Jason K. , Barber L. Tom , Roberts Trenton L. , Gbur Edward E. 
Published: June 2021

AbstractDicamba residues in sprayers are difficult to remove and may interact with subsequent herbicides, including contact herbicides labeled for use in soybean. Without proper tank cleanout, applicators treating dicamba-resistant and non–dicamba resistant crops are at risk of contaminating the spray solution with dicamba residue from previous applications. Experiments were conducted in Fayetteville, AR, in 2018 and 2019, with the first experiment evaluating consequences of dicamba tank contamination with contact herbicides and the second experiment addressing the impact of dicamba exposure on a glufosinate-resistant soybean cultivar relative to a contact herbicide application. Experiments for tank contamination and timing of dicamba exposure were designed as a three-factor and a two-factor randomized complete block with four replications, respectively, considering site-year as a fixed effect in each experiment. Dicamba at 0, 0.056, 0.56, and 5.6 g ae ha−1 was applied alone, with glufosinate, with acifluorfen, or with glufosinate plus acifluorfen to V3 soybean. Dicamba applied in combination with contact herbicides exacerbated visible auxin symptomology over dicamba alone at 21 and 28 d after treatment (DAT), while dicamba at 5.6 g ae ha−1 reduced soybean height. Injury and height reductions caused by dicamba mixtures with contact herbicides did not reduce grain yield. In the second experiment, dicamba was applied at 2.8 g ae ha−1 at VC, V1, V2, and V3 and at 3, 7, and 10 d after a glufosinate application to V3 soybean (DATV3). Greater soybean injury was observed when dicamba exposure followed a glufosinate application than when dicamba preceded glufosinate or was applied in a mixture with glufosinate, with yield reductions resulting from 7 and 10 DATV3 dicamba applications. Dicamba exposure in the presence of contact herbicides resulted in increased auxin symptomology and can be intensified if soybean are exposed to dicamba following a contact herbicide application.