bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circular convolution-based feature extraction algorithm for classification of high-dimensional datasets
Authors: Tajanpure Rupali , Muddana Akkalakshmi 
Published: October 2021

AbstractHigh-dimensional data analysis has become the most challenging task nowadays. Dimensionality reduction plays an important role here. It focuses on data features, which have proved their impact on accuracy, execution time, and space requirement. In this study, a dimensionality reduction method is proposed based on the convolution of input features. The experiments are carried out on minimal preprocessed nine benchmark datasets. Results show that the proposed method gives an average 38% feature reduction in the original dimensions. The algorithm accuracy is tested using the decision tree (DT), support vector machine (SVM), andK-nearest neighbor (KNN) classifiers and evaluated with the existing principal component analysis algorithm. The average increase in accuracy (Δ) is 8.06 for DT, 5.80 for SVM, and 18.80 for the KNN algorithm. The most significant characteristic feature of the proposed model is that it reduces attributes, leading to less computation time without loss in classifier accuracy.
An atypical presentation of a pathogenic STK11 gene variant in siblings not fulfilling the clinical diagnostic criteria for Peutz-Jeghers Syndrome
Authors: Shaunak Meera , Side Lucy , Afzal Nadeem , Davies Justin Huw 
Published: October 2021

Abstract

Objectives
To report an atypical presentation of a pathogenic STK11 gene variant in siblings not fulfilling the clinical diagnostic criteria for Peutz-Jeghers Syndrome (PJS).

Case presentation
Two siblings presented with prepubertal gynaecomastia and bilateral macro-orchidism, without mucocutaneous pigmentation or gastrointestinal symptoms. There was no family history of PJS. Sibling 1 had unilateral gynaecomastia. Sibling 2 had bilateral gynaecomastia, advanced bone age and bilateral testicular microlithiasis, not indicative of a large-cell calcifying Sertoli cell tumour. Genetics revealed a paternally inherited heterozygous pathogenic STK11 variant (910C>T) in both siblings. The diagnosis was confirmed following the identification of multiple intestinal polyps in their father.

Conclusions
Prepubertal gynaecomastia and prepubertal macro-orchidism (testicular enlargement without virilisation), always warrant endocrinological investigation, with PJS being an important differential diagnosis. Children may not fulfil the clinical criteria for a diagnosis of PJS at presentation. Genetic testing and gastroenterological investigation of parents may aid diagnosis.
Der sexuelle Missbrauch von Kindern und kinderpornografische Delikte – Längerfristige Entwicklungsverläufe und ein empirischer Vergleich verschiedener Fallgruppen
Authors: Biedermann Jürgen , Rüdiger Thomas-Gabriel 
Published: October 2021

Zusammenfassung
Der sexuelle Missbrauch von Kindern und kinderpornografische Delikte werden in der Gesellschaft, den Medien und der Politik häufig sehr emotional diskutiert, gepaart mit als irritierend erlebten Schwierigkeiten bei der Nachvollziehbarkeit der Hintergründe für diese Taten und einem Fokus auf herausragende und besonders schwerwiegende Einzelfälle. Bisherige Forschungsergebnisse verweisen hingegen zuvorderst auf eine große Heterogenität des Phänomens, welche sowohl für das Verständnis als auch eine effektive Strafverfolgung und Prävention dieser Straftaten zu berücksichtigen ist. Die vorliegende Untersuchung analysiert anhand der bundesweiten polizeilichen Kriminalstatistik längerfristige Verläufe der registrierten polizeilichen Fälle und zentraler kriminologischer Kenngrößen in diesen Deliktbereichen über die letzten 20 Jahre. Zudem wurden Informationen des polizeilichen Datenbanksystems POLAS des Landes Brandenburg zu Straffällen herangezogen, die zwischen 2013 und 2018 an die polizeiliche Kriminalstatistik gemeldet wurden. Auf dieser Basis werden verschiedene Fallgruppen des sexuellen Missbrauchs von Kindern nach den §§ 176 ff. StGB (n= 2248) und kinderpornografischer Delikte nach § 184 b StGB (n=592) hinsichtlich wesentlicher Fall- und Tatmerkmale kontrastiert und charakterisiert. Besonderes Augenmerk liegt hierbei auf einer Fallgruppe, die durch sexuelle Missbrauchshandlungen unter gleichzeitiger Herstellung pornografischer Aufnahmen gekennzeichnet ist. Für diese Fallgruppe erfolgte in Ergänzung zu den statistischen Analysen zusätzlich eine qualitative Analyse freitextlicher Fallbeschreibungen. Die erzielten Ergebnisse werden im Hinblick auf zielführende repressive und präventive Interventionsansätze diskutiert, wobei sich die Relevanz einer differenzierten Betrachtung verschiedener Tatbegehungskonstellationen erneut bestätigt, welche auch im Kontext der im Juni 2021 verkündeten Reform der einschlägigen Rechtsvorschriften bei Sexualstraftaten mit kindlichen Opfern berücksichtigt werden sollte.
Nano drug delivery systems improve metastatic breast cancer therapy
Authors: Zhu Runqi , Lang Tianqun , Yin Qi , Li Yaping 
Published: October 2021

Abstract
Despite continual progress in the technologies and regimens for cancer therapy, the treatment outcome of fatal metastatic breast cancer is far from satisfactory. Encouragingly, nanotechnology has emerged as a valuable tool to optimize drug delivery process in cancer therapy via preventing the cargos from degradation, improving the tumor-targeting efficiency, enhancing therapeutic agents’ retention in specific sites, and controlling drug release. In the last decade, several mechanisms of suppressing tumor metastasis by functional nano drug delivery systems (NDDSs) have been revealed and a guidance for the rational design of anti-metastasis NDDSs is summarized, which consist of three aspects: optimization of physiochemical properties, tumor microenvironment remodeling, and biomimetic strategies. A series of medicinal functional biomaterials and anti-metastatic breast cancer NDDSs constructed by our team are introduced in this review. It is hoped that better anti-metastasis strategies can be inspired and applied in clinic.
Simulation of boronizing kinetics of AISI 316 steel with an integral diffusion model
Authors: Keddam Mourad , Topuz Polat , Aydin Özlem 
Published: October 2021

Abstract
Boriding or boronizing is a type of surface property improvement process applied to metal or some non-metal materials by diffusion. The calculation of diffusion kinetics is also very important as it is a diffusion controlled process. Today, many researchers perform kinetic calculations by applying the Second Fick’s law to the Arrhenius equation. In this study, as an alternative to conventional kinetic calculations, the mathematical modeling of diffusion kinetics has been performed using the integral diffusion model. For the boronizing experiments, the pack-boronizing method was chosen and AISI 316 austenitic stainless steel was used. The experiments were carried out at three temperatures and for three times; Ekabor 2 was used as the boronizing agent. The detailed diffusion kinetics calculations were made using the data obtained from the experiments in the mathematical modeling.
Quality optimization and process capability analysis of ring spun Supima cotton yarn
Authors: Oncul Kursat 
Published: October 2021

Abstract
The response surface method and process capability analysis were conducted in this study to improve evenness, hairiness, imperfections, and tensile strength of ring spun Supima cotton yarn by optimizing values of spinning parameters including traveler mass, yarn density, spindle speed, and yarn twist. The yarns were spun into three densities: 20 Ne, 30 Ne, and 38 Ne. An USTER Tester 5-S800 was used to evaluate the irregularity parameters of yarn. A Lloyd tester was also used to determine the yarn breaking load. The response surface method was applied to optimize the statistical values obtained from the tests of the yarns produced based on the combination values of system parameters. Each response was subjected to a response surface design study, and the optimal values were achieved by using a response optimizer to perform multiple response optimization. Interpreting the response surface design results yielded information such as the absolute values of effects, response degree of significance, data compatibility, and model suitability. Individual desirability, composite desirability, different estimates for each response, and the relationship between response and system variables were all revealed by interpreting the response optimization results. The capability indices of process capability analysis were used to compare process performance before and after response optimization. By interpreting the capability indices’ values of process capability analysis, the capability of the process to meet requirements and improvement potential were acquired. The data was analyzed by implementing Minitab software (Version 19).
Effect of vibratory peening on wear behavior of Al2O3/SiCp reinforced Al2024 aircraft alloy
Authors: Er Yusuf 
Published: October 2021

Abstract
Aluminum alloys and composites are widely used in the field of aviation due to their high strength/weight ratio. However, due to their relatively low hardness values, they have poor wear resistance. In this study, a hybrid composite material was produced through stir casting method. Al2O3 and SiCp particles in 2.5, 5 and 7.5 wt.-% were added into Al2024 matrix material, which is widely used in the aviation industry, in order to increase the wear resistance of composites. The vibratory peening process was applied to the surfaces of the produced samples. The samples were then subjected to a reciprocating wear test. As a result of the tests, it was observed that the vibratory peening process has an important effect on the wear resistance of the samples.
Nano-scale delivery: A comprehensive review of nano-structured devices, preparative techniques, site-specificity designs, biomedical applications, commercial products, and references to safety, cellular uptake, and organ toxicity
Authors: Abdellatif Ahmed A. H. , Mohammed Hamdoon A. , Khan Riaz A. , Singh Varsha , Bouazzaoui Abdellatif , Yusuf Mohammad , Akhtar Naseem , Khan Maria , Al-Subaiyel Amal , Mohammed Salman A. A. , Al-Omar Mohsen S. 
Published: October 2021

Abstract
This review focuses on nano-structured delivery devices prepared from biodegradable and biocompatible natural and synthetic polymers, organic raw materials, metals, metal oxides, and their other compounds that culminated in the preparation of various nano-entities depending on the preparative techniques, and starting raw materials’ utilizations. Many nanoparticles (NPs) made of polymeric, metallic, magnetic, and non-magnetic origins, liposomes, hydrogels, dendrimers, and other carbon-based nano-entities have been produced. Developments in nanomaterial substrate and end products’ design, structural specifications, preparative strategies, chemo-biological interfacing to involve the biosystems interactions, surface functionalization, and on-site biomolecular and physiology-mediated target-specific delivery concepts, examples, and applications are outlined. The inherent toxicity, and safety of the design concepts in nanomaterial preparation, and their applications in biomedical fields, especially to the organs, cellular and sub-cellular deliveries are deliberated. Bioapplications, the therapeutic delivery modules’ pharmacokinetics and medicinal values, nanopharmaceutical designs, and their contributions as nano-entities in the healthcare biotechnology of drug delivery domains have also been discussed. The importance of site-specific triggers in nano-scale deliveries, the inherent and induced structural specifications of numerous nanomaterial entities belonging to NPs, nano-scale composites, nano-conjugates, and other nano-devices of organic and inorganic origins, near biological systems are detailed. Modifications that provide nano-deliveries of their intrinsic therapeutic actions, through structural and physicochemical characteristics modifications, and the proven success of various nano-delivery devices and currently available commercial nanomedicinal and nanopharmaceutical products are also provided.
Rufinus of Aquileia’s Historia ecclesiastica and Historia monachorum in Aegypto: A Dual Program of Monastic Historiography
Authors: Cain Andrew 
Published: October 2021

Abstract
The Historia monachorum in Aegypto is an anomaly among the vast corpus of translations produced by Rufinus of Aquileia, not least because it represents his only known experiment with the literary genre of monastic hagiography. This article explores the question of why he undertook this project at all and considers this issue of authorial intention in the broader context of Rufinus’ work as a church historian. In particular, I propose that he envisaged the Historia monachorum in Aegypto in part as a follow-up, or companion piece, to his recently completed Historia ecclesiastica and intended both writings to articulate cooperatively his vision of the monks of Egypt as prime movers in the Christianization of the fourth-century Roman Empire.
Digitale Assistenz in der Additiven Fertigung
Authors: Vogt Maximilian , Möller Mauritz , Emmelmann Claus 
Published: October 2021

Abstract
Augmented-Reality-basierte digitale Assistenzsysteme werden bereits erfolgreich im industriellen Kontext eingesetzt, um die Arbeitskräfte bei manuellen Tätigkeiten zu unterstützen. Die Nutzung in der additiven Fertigung wurde allerdings noch nicht umfassend untersucht. Angelehnt an das klassische Technologiemanagement wurde ein methodisches Vorgehen entwickelt, um anwendungsspezifische Use Cases für die Additive Fertigung zu adaptieren.
A versatile genetic toolbox for Prevotella copri enables studying polysaccharide utilization systems
Authors: Li Jing , Gálvez Eric J C , Amend Lena , Almási Éva , Iljazovic Aida , Lesker Till R , Bielecka Agata A , Schorr Eva‐Magdalena , Strowig Till 
Published: October 2021

AbstractPrevotella copri is a prevalent inhabitant of the human gut and has been associated with plant‐rich diet consumption and diverse health states. The underlying genetic basis of these associations remains enigmatic due to the lack of genetic tools. Here, we developed a novel versatile genetic toolbox for rapid and efficient genetic insertion and allelic exchange applicable to P. copri strains from multiple clades. Enabled by the genetic platform, we systematically investigated the specificity of polysaccharide utilization loci (PULs) and identified four highly conserved PULs for utilizing arabinan, pectic galactan, arabinoxylan, and inulin, respectively. Further genetic and functional analysis of arabinan utilization systems illustrate that P. copri has evolved two distinct types of arabinan‐processing PULs (PULAra) and that the type‐II PULAra is significantly enriched in individuals consuming a vegan diet compared to other diets. In summary, this genetic toolbox will enable functional genetic studies for P. copri in future.
Leaf Anatomical Study of Solanum Species (Solanaceae) in Iran
Authors: Mosaferi S. , Hasanabadi H. , Keshavarzi M. , Eskandari M. 
Published: October 2021

Solanum
(Solanaceae) comprises cultivated and wild plants with 1400 species in the world and 14 species in Iran. Solanum is a taxonomically complex genus due to morphological similarities, phenotypic plasticity and hybridisation. Limited studies were done on anatomical features of this important genus. In this project, 10 native and exotic species of Solanum in Iran belonging to two subgenera were examined anatomically. Leaf mesophyll and midrib and indumentum were analysed using light microscope. Hand-made cross section method and Toluidine blue as colouring agent were used. Characters as length and width of main vascular bundle, thickness of collenchyma, trichome density, thickness of parenchyma strand, thickness of lamina and length and shape of midrib were diagnostic features among species studied. In UPGMA tree and PCA ordination, species of two subgenera were separated from each other. Results of this study confirmed the taxonomic importance of anatomical characters in Solanum species studied.
Hybrid nanostructured PAN@NiCu(CO3)(OH)2 composite for flexible high-performance supercapacitors
Authors: Lee Damin , Verma Anjneya , Lê Khan , Fischer Thomas , Kim Kwang Ho , Mathur Sanjay 
Published: October 2021

Abstract
A binder-free porous NiCu(CO3)(OH)2 composite was grown on a polyacrylonitrile (PAN) nanofiber substrate using a hydrothermal method. PAN nanofibers were fabricated by the electrospinning method, thus producing a substrate with a nano-sized diameter and high specific surface area. The composite NiCu(CO3)(OH)2 nanowires on PAN nanofibers provided the large specific surface area required for the redox reaction. Transition metal-based nanowires and nano-sized PAN substrates indicate a synergistic effect in electrochemical performance. The NiCu(CO3)(OH)2 on PAN composite showed a remarkable maximum specific capacity of 870 mAh g−1 at a current density of 3 A g−1, which indicates that it can be a suitable electrode material. In addition, an asymmetric supercapacitor with NiCu(CO3)(OH)2 on PAN composite as the cathode and graphene as the anode showed an ultra-high energy density of 89.2 W h kg−1 at a power density of 835 W kg−1 and a capacitance retention of 90.1% after 5000 cycles.

Graphic abstract
PERCEPÇÕES DE PROFESSORES BACHARÉIS SOBRE A CONSTRUÇÃO DE SUA IDENTIDADE PROFISSIONAL DOCENTE
Authors: Dias Maria Isabel , Assis Ferreira Adriana , Resende Allain Luciana 
Published: October 2021

Dado o acentuado crescimento do Ensino Superior no Brasil nas três últimas décadas, caracterizado pelo aumento do número de instituições, de cursos, de matrículas e de funções docentes, este artigo, decorrente de uma pesquisa de mestrado, buscou identificar, na perspectiva de dez professores bacharéis que atuam em uma grande universidade pública mineira, como se dá a constituição da sua identidade profissional docente. Foi realizada uma pesquisa de abordagem qualitativa, descritiva e exploratória. A partir da análise de conteúdo das entrevistas semiestruturadas chegou-se a cinco categorias de análise: Saberes docentes; História de vida; A inserção na Universidade e o perfil do estudante; Alguns desafios e possibilidades – a realidade em sala de aula e Crenças sobre identidade profissional docente. Neste artigo apresentamos subcategorias dos Saberes Docentes. A análise evidenciou que os sujeitos reconhecem que os saberes provenientes dos cursos de formação inicial em bacharelado não apresentam condições de compreender toda a complexidade que envolve os saberes necessários à docência. Eles também revelam o sentimento de que precisam ter aptidão para construir novos saberes e ressignificar os existentes em sua prática pedagógica. No entanto, revelam a inexistência de uma política institucional de apoio aos docentes que contemple ações sistemáticas, que venham a suprir seu déficit formativo. Desta forma, entendendo que constituição da identidade profissional docente é subjetiva, mas também coletiva, concluímos ser imprescindível que as Instituições de Ensino Superior voltem o seu olhar para a formação continuada do seu corpo docente, de forma a acolher e apoiar os docentes em seu desenvolvimento profissional.
Caracterización de dientes en una población con tratamiento de endodoncia atendida en una clínica odontólogica universitaria mediante tomografia cone beam y comparación con radiografía periapical
Authors: Pineda Vélez Eliana , Bedoya Morales Samantha , Echeverri Romero Frank David , Guerra Bedoya Yeison Andrés , Osorno Jaramillo Luisa , Franco Aguirre John Querubín 
Published: October 2021

Introducción: las imágenes que proporcionan las radiografias son en dos dimensiones. Esto no permite en muchas ocasiones una visualización real de las condiciones anatomicas de los dientes y especialmente de los tejidos periapicales. Es por esto que la tomografia cone beam puede proporcionar una imagen que permita identificar mejor el estado de los dintes y su respuesta a la terpaia endodontica.
Objetivo: caracterizar dientes en una población con tratamiento de mediante tomografia cone beam y comparación con radiografía periapical.
Materiales y medotods: estudio descriptivo transversal, en el cual se realizó un examen clínico detallado, se tomó la radiografía y tomografía cone beam de los pacientes que previamente habían sido tratados con endodoncia, Se realizó un análisis descriptivo de la información. Se evalúo la concordancia, 0,56.
Resultados: se evidencia que la frecuencia de lesión por tomografia fue de 29 %. Mientras que el diagnostico de lesión radiográfica se presentó en el 19,4 % de los dientes analizados. Se encuentra además que la mayor frecuencia de lesión reportada por tomografia se presentó en dientes con obturaciones incompletas, de la misma forma que en mayor en dientes multirradiculares,
Conclusion: la tomografia cone beam es una herramienta que aun no es muy utilizada ni reconocida por los clínicos en su potencial diagnostico, y de plan de tratamientos de casos endodonticos.
Experimental study of mechanisms of disturbances of hypothalamic regulation of reproduction
Authors: Arutjunyan A. V. , Kerkeshko G. О. , Stepanov М. G. , Korenevsky А. V. , Ailamazyan Е. К. 
Published: October 2021

Summary: Diurnal rhythms of the activity of a number of monoaminergic systems of the hypothalamus (norepinephrine and serotonin in PA and ME-ArN, as well as dopamine in ME-ArN) have been shown to depend on the functioning of an endogenous circadian oscillator in SCN of the hypothalamus. Light modifies the diurnal rhythms of the neurotransmitters. Enhancement of the activity of the noradrenergic systems with sex steroids in proestrus is an important mechanism of the forming of the preovulatory surge of GnRH and gonadotropines secretion, which initiates ovulation. Consideration of our own experimental data and literature allow the supposition that the change of diurnal rhythms of norepinephrine in PA and ME-ArN could result in profound disturbances of hypothalamic regulation of reproductive cycles and be one of key reasons for negative effect of xenobiotics on reproduction.
Supported by RFBR grant 04-04-49204.