bluuebunny/crossref_metadata_2025_split huggingface dataset:
DEVELOPMENT OF MATHEMATICAL COMIC LEARNING MEDIA (KOMAT) BASED ON STUDENT’S MATHEMATICAL CONNECTION ABILITIES
Authors: Pratiwi Aprilia Sukma , Wulantina Endah 
Published: December 2024

The aims of this study were 1) to develop mathematical comics based on mathematical connection skills, 2) to find out student’s responses to mathematical comics based on mathematical connection abilities. This research uses research and development procedures (Research and Development) or R&D. The model used in this study is the 4-D development model which consist of four stages of development, namely the define stage, the design stage, the develop stage, and the disseminate stage. The product trial subjects in this study were 29 students of grade VIII junior high school. The result of the study showed that the developed Mathematical Comics (KOMAT) met the criteria for being used as learning media. This can be seen based on the validation result of material experts of 3,35 with very suitable criteria for use, and media expert validation of 2,95 with appropriate criteria for use. On the result of product trials on students, based on the result of the questionnaire responses of students to the attractiveness of math comic learning media (KOMAT) it was obtained an average of 3,19 with attractive criteria. So it can be concluded that the mathematics comic learning media (KOMAT) based on students’ mathematical connection abilities is feasible and interesting to use in school learning.
Оцінка внеску 228Ra в дозу опромінення мешканців м. Києва, які споживають артезіанську воду
Authors: Buzynnyi M. , Pryhodko R. , Mykhailova L. , Panasiuk M. 
Published: December 2024

У статті наведено опис запровадження високочутливих методів визначення активності ізотопів радію у питній воді і приклад використання цих методів для оцінки доз опромінення мешканців м. Києва від природних радіонуклідів в артезіанській воді. Для вимірювань активності 226Ra, 228Ra і суми ізотопів урану (∑U) використовували α/β-рідинно-сцинтиляційний спектрометр та γ-спектрометр з напівпровідниковим детектором. Характерною рисою запроваджених методів є простота – мінімальна кількість технологічних операцій. Для концентрування радію та виготовлення колонок використано доступні іонообмінні смоли та матеріали. Суму ізотопів урану визначали методом рідинно-сцинтиляційного лічення після екстракції урану розчином трибутилфосфату в орто-ксилолі. Оцінки доз опромінення виконані в термінах отриманої за життя дози з урахуванням вік-залежних дозових та відповідних вагових коефіцієнтів. Досліджено 25 проб артезіанської води, відібраної в м. Києві з артезіанських свердловин та бюветних комплексів. Питома активність 228Ra у досліджених зразках складає від 7 мБк/л до 99 мБк/л. Ці значення відповідають накопиченій за життя дозі опромінення від 6 мкЗв до 90 мкЗв на рік, що для різних джерел може складати від 79,2 % до 97,5 % від загальної дози опромінення, яка враховує надходження з питною водою також урану і радію.
Multi-Robot Radiation Reconnaissance in the Chornobyl NPP Exclusion Zone
Authors: Saveliev M. , Shtefan V. , Proskurin O. , Pantin M. , Martin P. G. , Grechaninov V. , Havrylko Ye. 
Published: December 2024

Problems associated with radiation confinement, reconnaissance and mapping in the Chornobyl Exclusion Zone (e.g. scale of the area, natural risks and consequences of combat operations) make the development and deployment of robotic radiation reconnaissance technologies and methodologies relevant and timely. This effort proposes a novel robotic radiation reconnaissance system consisting of three different types of robots: (i) a wheeled unmanned ground vehicles that serves as a carrier and control center for (ii) a quadrupedal unmanned ground vehicles and (iii) a multirotor aerial vehicles – both for surveying in hard-to-reach and inaccessible areas. The combination of the capabilities and strengths of each of the robotic platforms, each transporting a radiation detection payload, enhances the overall quality of the radiation survey undertake. The heavy carrier platform first moves along the predefined route, stopping at certain points, or if the threshold radiation levels are exceeded. During the pause, the wheeled platform deploys the abovementioned reconnaissance robots, the missions for which are autonomously managed by the control center platform. Reconnaissance robots subsequently send data about their surroundings to the control center, which resultantly collects and processes the data adjusting the routes of the reconnaissance robots as required. The Robot Operating System (ROS) is proposed as a meta-operating system to control and manage data exchange between components like robots and measuring devices to tackle the challenge of integrating systems from different manufacturers into a unified system. Additionally, a functional decomposition of the system is presented.
واقع مشاركة أولياء الأمور في البرنامج التربوي الفردي للطالبات ذوات اضطراب طيف التوحد من وجهة نظر المعلمات بمدينة الطائف
Authors: أسماء فايز عيضة الحصيني  
Published: December 2024

هدفت إلى التعرف على واقع مشاركة أولياء الأمور في البرنامج التربوي الفردي للطالبات ذوات اضطراب طيف التوحد من وجهة نظر المعلمات، والتعرف على معوقات مشاركة أولياء الأمور في البرنامج التربوي الفردي للطالبات ذوات اضطراب طيف التوحد من وجهة نظر المعلمات، والتعرف على المقترحات للتغلب معوقات مشاركة أولياء الأمور في البرنامج التربوي الفردي للطالبات ذوات اضطراب طيف التوحد من وجهة نظر المعلمات، والكشف عن مدى وجود فروق ذات دلالة إحصائية حول واقع مشاركة أولياء الأمور في البرنامج التربوي الفردي للطالبات ذوات اضطراب طيف التوحد من وجهة نظر المعلمات تعزى لمتغيرات (المؤهل العلمي–المرحلة الدراسية-عدد سنوات العمل)، واتبعت الدراسة المنهج الوصفي المسحي والاستبانة كأداة لجمع البيانات، وشمل مجتمع الدراسة معلمات التربية الخاصة في مدارس مدينة الطائف، وبلغت العينة 66 معلمة.
وتوصلت الدراسة لنتائج أبرزها:

وجود تفاوت في درجة موافقة أفراد الدراسة من معلمات التربية الخاصة في مدارس مدينة الطائف على عبارات محور (واقع مشاركة أولياء الأمور في البرنامج التربوي الفردي للطالبات ذوات اضطراب طيف التوحد من وجهة نظر المعلمات) حيث تراوحت الإجابات بين متوسطة/كبيرة.
وأن أبرز معوقات المشاركة تتمثل في ضعف وعي أولياء الأمور بحالة الطالبات.
وأن أبرز المقترحات للتغلب على المعوقات تتمثل في جذب أولياء أمور الطالبات ذوات اضطراب طيف التوحد وتعريفهم بالبرنامج التربوي.
وعدم وجود فروق ذات دلالة إحصائية عند مستوى الدلالة (0.05) أو أقل بين استجابات أفراد الدراسة من معلمات التربية الخاصة في مدارس مدينة الطائف حول محور واقع مشاركة أولياء الأمور في البرنامج التربوي الفردي للطالبات ذوات اضطراب طيف التوحد باختلاف المؤهل العلمي أو عدد سنوات العمل، ووجود فروق ذات دلالة إحصائية عند مستوى الدلالة (0.05) أو أقل بين استجابات أفراد الدراسة من معلمات التربية الخاصة في مدارس مدينة الطائف حول محور واقع مشاركة أولياء الأمور في البرنامج التربوي الفردي للطالبات ذوات اضطراب طيف التوحد باختلاف المرحلة التعليمية.

وخرجت الدراسة بتوصيات أبرزها:

ضرورة جذب أولياء أمور الطالبات ذوات اضطراب طيف التوحد وتعريفهم بالبرنامج التربوي وأهميته في تحسين عملية التعلم.
وأهمية التقييم الدوري للبرنامج التربوي الفردي من قبل المدرسة.
ضرورة إيجاد قنوات تواصل مفتوحة مناسبة بين المدرسة وأولياء أمور الطالبات ذوات اضطراب طيف التوحد.
PELATIHAN PEMBELAJARAN INOVATIF MELALUI PEMBUATAN VOICE THREADS, BLOGGING, SOCIAL BOOKMARKING, SINIAR ATAU PODCAST DAN SCREENCAST DI SMAN 10 KOTA BENGKULU
Authors: I Nyoman Candra  , Elvia Rina , Wiwit  
Published: December 2024

SMAN 10 Bengkulu City is one of the Senior High Schools in Bengkulu City which has implemented independent Curriculum. This curriculum allows teachers to apply learning methods and develop teaching materials independently. This requires teachers to have skills in designing innovative learning. We conducted a community service program aiming to train teachers on innovative learning through creating Voice Threads, Blogging, Social Bookmarking, Podcasts, and Screencasts. This program was initiated by introducing Voice Threads, Blogging, Social Bookmarking, Podcasts, and Screencasts. We also demonstrate how to use them in creating innovative learning. Afterwards, we allowed the participants to give question in question answer section. At the end of the program, we sent a quistionaire to obtain a feedback of the program. The data showed that this program is useful for them as a teacher because it is something new and can improve their knowledge. This was also insightful to design innovative learning. Overall, they were satisfying with this program.
Strategi Penanganan Kawasan Permukiman Kumuh Pesisir Pekalongan melalui Mitigasi Bencana dan Pembangunan Berkelanjutan
Authors: Pamungkas Aprilia Fitri , Nugroho Widi Hari , Yudiana Bachtiar 
Published: December 2024

ENGLISHTidal flooding is a climate change impact in the northern region of Java, including Pekalongan Regency. Tidal flooding in Pekalongan Regency takes place every year and it is difficult to handle because simultaneously with land subsidence and rising sea levels due to global warming. Tidal flooding is related to the level of slum settlements, especially in Wonokerto District. Wonokerto residents who are submerged by tidal floods tend to stay and adapt to existing environmental conditions rather than migrate to other locations. This study analyzed the strategy for handling slum settlements in coastal communities of Pekalongan Regency that have adapted to tidal floods. This study used mixed methods between qualitative and quantitative descriptive methods through SWOT and a strategic planning approach that processes the results of field observations, citizen interviews and literature studies of regional policies. This study integrates disaster mitigation and sustainable development aspects to build community resilience and produces 14 proposed strategies that must involve all relevant stakeholders, namely the Government; Wonokerto Community; and active Institutions/Organizations in the environmental, social and health fields to support the achievement of program goals and benefits. INDONESIABanjir rob merupakan dampak perubahan iklim di wilayah utara Jawa, salah satunya Kabupaten Pekalongan. Banjir rob di Kabupaten Pekalongan terus terjadi setiap tahunnya dan sulit ditangani karena berjalan bersamaan dengan penurunan muka tanah serta peningkatan muka air laut akibat pemanasan global. Banjir rob berdampingan erat dengan tingkat kekumuhan permukiman terutama di Kecamatan Wonokerto. Masyarakat Wonokerto yang terendam banjir rob cenderung tetap tinggal dan beradaptasi dengan kondisi lingkungan yang ada dibanding bermigrasi ke lokasi lain. Penelitian ini bertujuan menganalisis strategi penanganan permukiman kumuh pada masyarakat pesisir Kabupaten Pekalongan yang telah beradaptasi dengan banjir rob. Penelitian ini menggunakan metode campuran antara deskriptif kualitatif dan kuantitatif melalui SWOT dan pendekatan strategic planning yang mengolah hasil observasi lapangan, wawancara warga dan studi pustaka kebijakan daerah. Penelitian ini mengintegrasikan aspek mitigasi bencana dan pembangunan berkelanjutan guna membangun ketahanan komunitas dan menghasilkan 14 usulan strategi yang harus melibatkan seluruh stakeholder terkait yaitu Pemerintah; Masyarakat Wonokerto; serta Lembaga/Organisasi aktif di bidang lingkungan, sosial maupun kesehatan guna mendukung ketercapaian tujuan dan manfaat program.
Model-based design of a pneumatic actuator for a dynamically reconfigurable socket for transtibial amputees
Authors: Mollaee Saeed , HajiRassouliha Amir , Budgett David M. , Taberner Andrew J. , Nielsen Poul M. F. 
Published: December 2024

In this work, a cost-effective, scalable pneumatic silicone actuator array is introduced, designed to dynamically conform to the user’s skin and thereby alleviate localised pressure within a prosthetic socket. The appropriate constitutive models for developing a finite element representation of these actuators are systematically identified, parametrised, and validated. Employing this computational framework, the surface deformation fields induced by 270 variations in soft actuator array design parameters under realistic load conditions are examined, achieving predictive accuracies within 70 µm. The results elucidate how individual design factors influence surface deformation and, consequently, pressure distribution. A novel speckle imaging technique is employed to address the complex non-linear deformations, enabling surface displacement measurements with an accuracy of approximately 40 µm. These measurements confirm that the Ogden N3 model can predict actuator deformation with an accuracy of 16%. These findings elucidate the relationships among actuator geometry, material behaviour, and surface deformation. Although demonstrated in a dynamically reconfigurable socket for transtibial amputees, these insights are readily transferable to other robotics applications that require soft, deformable, load-bearing interfaces. This validated modelling strategy and imaging technique provide a foundation for optimising soft actuator arrays, ultimately improving user comfort and enhancing the functionality of future prosthetic and robotic devices.
Cell-free supernatant of Levilactobacillus brevis (RAMULAB51) from coconut inflorescence sap (Neera) enhances glucose uptake and PPAR-γ in 3T3-L1 adipocytes and inhibits α-glucosidase and α-amylase
Authors: Kumari V B Chandana , Ramu Ramith , Shirahatti Prithvi S. , Alam Perwez , Wong Ling Shing 
Published: December 2024

IntroductionLactic acid bacteria are prized for their probiotic benefits and gut health improvements. This study assessed five LAB isolates from Neera, with RAMULAB51 (Levilactobacillus brevis, GenBank ON171686.1) standing out for its high hydrophobicity, auto-aggregation, antimicrobial activity, and enzyme inhibition. It evaluated RAMULAB51’s potential in probiotics and diabetes management, focusing on its effects on digestive enzyme inhibition, glucose uptake, and adipocyte function.MethodsIsolates were characterized by Gram staining, catalase reaction, growth at 37°C, and tolerance to phenol, pH, and gastrointestinal conditions. Molecular identification using 16S rRNA sequencing. Evaluations included hydrophobicity, auto-aggregation, HT-29 cell line adhesion, antimicrobial activity, and antibiotic susceptibility. Enzyme inhibition was measured for α-glucosidase and α-amylase using cell-free supernatant, cell extract, and intact cells. Adipogenesis was assessed through Oil-Red O staining, gene expression analysis (PPAR-γ, C/EBPα, Adiponectin, Glut-4, FAS), and glucose uptake assays on 3T3-L1 cells.ResultsAll isolates showed good tolerance to pH (≤9.15 CFU/ml), phenol (≤9.90 CFU/ml), hydrophobicity (≤78.14%), and auto-aggregation (≤92.23%). RAMULAB51 demonstrated the highest tolerance, hydrophobicity, and auto-aggregation. It strongly co-aggregated with Micrococcus luteus and Bacillus subtilis, showing significant antimicrobial activity with a 24 mm inhibition zone against Micrococcus luteus. All isolates were sensitive to Ampicillin, Azithromycin, Streptomycin, and Tetracycline, but resistant to Methicillin and Vancomycin. RAMULAB51 demonstrated the highest enzyme inhibition: α-glucosidase (68.45% CFS, 60.18% CE, 42.15% IC) and α-amylase (80.74% CFS, 61.23% CE, 35.12% IC). By inhibiting these digestive enzymes, RAMULAB51 reduces the conversion of carbohydrates into glucose, thereby decreasing blood glucose levels. This reduction in circulating glucose subsequently influences adipocyte function, as evidenced by the enhanced glucose uptake (1000 µg/mL) and upregulation of PPAR-γ, C/EBPα, Adiponectin, and Glut-4, alongside the downregulation of FAS.ConclusionThe study highlights RAMULAB51’s potential for improving glucose and lipid metabolism. Further, in vivo research is needed to explore its full therapeutic benefits. These findings confirm RAMULAB51’s significant probiotic potential and its promise for diabetes management, warranting further clinical investigation.
A novel anxiety-associated SNP identified in LYNX2 (LYPD1) is associated with decreased protein binding to nicotinic acetylcholine receptors
Authors: Anderson Kristin R. , Cao Wenpeng , Lee Hui Sun , Crenshaw Mark A. , Palumbo Talulla B. , Fisher-Perez Ethan , DeGraaf Amanda , Rogu Peter , Beatty Maria A. , Gracias Gabrielle M. , Pisapati Avani V. , Hoffman Katie , McLaughlin Krystle J. , Hupbach Almut , Im Wonpil , Zhang X. Frank , Miwa Julie M. 
Published: December 2024

IntroductionAnxiety disorders are among the most common mental illnesses in the US. An estimated 31.1% of U.S. adults experience any anxiety disorder at some time in their lives. Understanding some of the molecular underpinnings of anxiety could lead to improved treatments over current strategies focusing on symptom relief rather than root causes. One significant neurotransmitter system exerting control over anxiety is the nicotinic receptor subdivision of the cholinergic system. The murine Lynx2 gene, encoding a protein modulator of nicotinic acetylcholine receptors, is expressed in anxiety-related neural circuitry in rodents and has been functionally associated with anxiety-like behavior.MethodsWe examined variations in the human LYNX2 (LYPD1) gene and their potential effects on anxiety levels in a cohort of 624 participants. Participants completed validated anxiety questionnaires (e.g., STICSA and STAI), which assessed both their current anxiety and their general tendency to experience anxiety. Possible functional alterations due to one such mutation was assessed through atomic force microscopy (AFM) and computational modeling.ResultsWe identified a previously unreported single nucleotide polymorphism (SNP) in the mature protein-coding region of LYNX2 that was associated with significantly higher than normal anxiety scores. These elevated scores resembled those seen in patients clinically diagnosed with generalized anxiety disorder and panic disorder, although this genetically defined subpopulation did not typically report such diagnoses. Through computational modeling of the homopentameric α7 nicotinic receptor subtype and in vitro atomic force microscopy (AFM), we discovered that a specific LYNX2 SNP is linked to a reduced binding affinity between the LYNX2 protein and nAChRs, offering a potential functional explanation for the role that this mutation may play in anxiety.DiscussionA polymorphism in LYNX2, which codes for an inhibitory modulator of nicotinic acetylcholine receptors, has the potential to lead to sensitized nicotinic receptor activity in anxiety-related circuits. The LYNX2 protein has been shown to bind to multiple nicotinic acetylcholine receptor subtypes, including α4β2, α7, and α3β4 subtypes, each of which have been shown to be involved in affective behaviors. This work suggests that a subpopulation of individuals harboring a deleterious mutation in LYNX2 may predispose them to anxiety through abnormal nicotinic receptor control. In the future, this work may lead to the development of a biomarker for anxiety or a diagnostic tool for the early detection of individuals with susceptibility to anxiety.
Malay translation and validation of modified checklist for autism in toddlers, revised with follow-up (M-CHAT-R/F)
Authors: Ariffin R. A. , Ismail J. , Abd Rahman F. N. , Wan Ismail W. S. , Ahmad N. , Abdul Ghafar A. , Yang W. W. , Masra F. , Kamal Nor N. 
Published: December 2024

IntroductionAutism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition diagnosed clinically based on phenotypic characteristics and criteria such as the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Due to its significant social, emotional, and psychological impacts, early identification and diagnosis are crucial for starting early intervention and improving outcomes. A screening tool is imperative in identifying young children at risk so timely intervention can be instituted. The Modified Checklist for Autism in Toddlers, Revised with Follow-up (M-CHAT-R/F) is a reliable and valid screening tool used worldwide, with the previous iteration used for a long time in Malaysia. To enhance ASD screening in Malaysia, the latest version of M-CHAT-R/F was translated into Malay and evaluated for reliability and validity, as majority of the population speaks Malay, while the tool is originally in English. This study is a cross-sectional study performed in the Universiti Kebangsaan Malaysia (UKM) hospitals, between May 1st, 2020, to June 30th, 2022.MethodologyThe English version of the M-CHAT-R/F was translated into Malay using forward and backward translation methods. Content and face validity were ascertained and a pilot study was performed for internal reliability. A total of 244 children attending clinics and wards in UKM hospitals aged 16-30 months were recruited based on three categories: children with typical development, suspected cases, and established cases of ASD. All caregivers of the recruited children were asked to complete the Malay M-CHAT-R/F. Reliability and validation assessments were performed.ResultsMalay M-CHAT-R/F was found to be a reliable tool with good internal consistency (Cronbach's alpha = 0.906, p &lt; 0.001). The Receiver Operating Characteristic (ROC) curve showed that cut-off scores of 2 on Malay M-CHAT-R/F lead to successful ASD classification with Area Under the Curve (AUC) = 0.887, p &lt; 0.001 with a 95% CI (0.840, 0.933).DiscussionThe assessment of the Malay M-CHAT-R/F showed satisfactory psychometric properties. Based on this study, the Malay M-CHAT-R/F is a reliable and valid screening tool to screen for ASD in children aged 16–30 months. Translating the M-CHAT-R/F into Malay is expected to improve community outreach and screening, which is essential for early diagnosis and timely intervention for children with ASD in Malaysia.
Prenatal diagnosis of midgut volvulus by fetal MRI: a retrospective study
Authors: Kou Chenguang , Song Yanfang , Gao Duo , Zhou Lixia 
Published: December 2024

BackgroundFetal midgut volvulus is a rare disease, with a high risk of potentially life-threatening fetal complications.PurposeThe aim of this study was to retrospectively analyze the imaging findings of fetal midgut volvulus diagnosed by magnetic resonance imaging (MRI) and explore its value in non-invasive prenatal diagnosis.MethodsA retrospective collection of data from 156 fetuses suspected of intestinal obstruction by ultrasound examination in our hospital was conducted. All ultrasound examinations showed fetal intestinal dilation and fetal MRI diagnosis suspected midgut volvulus in 32 cases (32/156), of which 18 cases (18/32) that underwent surgical treatment in the neonatal period were confirmed to have midgut volvulus. MRI signs in the 18 fetuses with midgut volvulus were analyzed.ResultsDuring MRI examination, all 18 fetuses showed gastric and/or intestinal dilatation, most of which showed different degrees of obstruction in T1-weighted images (WIs) and T2WIs, showing the “black and white sign” (14/18), “whirlpool sign” (10/18), and “coffee bean sign” (6/18). High signal intensity changes in diffusion-weighted imaging sequences were observed in intestinal tubes with ischemia and infarction. Direct signs of vascular torsion were observed in some cases (8/18). MRI signs indicated fetal midgut volvulus with hydramnios (16/18), meconium pseudocyst (7/18), meconium peritonitis (4/18), testicular hydrocele (3/18), and secondary pulmonary dysplasia (6/18). Operations confirmed the diagnosis of segmental midgut volvulus in 15 cases, complete midgut volvulus in 3 cases, and combined with intestinal atresia in 8 cases.ConclusionPrenatal MRI plays an important role in the diagnosis of fetal midgut volvulus and the discovery of its complications, which can guide the treatment after birth and provide a reference for the prognosis.