bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sports, Environment and Climate Change: the Carbon Footprint of Sports Facilities Based on Energy Consumption in Turkey
Authors: Atalay Ahmet , Demir Sevdagül 
Published: December 2024

In this research, it is aimed to make carbon footprint measurements related to energy consumption (electricity, natural gas) in sports facilities belonging to public institutions in Ardahan province in Turkey. Afterwards, it is aimed to discuss the suggestions for minimising the footprint of the type and characteristics of the facilities in the light of current literature. This research is limited to Ardahan province and conducted as a case study. In this context, the amounts of electricity and natural gas consumed in 10 sports facilities with different types and characteristics located in Ardahan provincial centre and districts for 12 months during 2023 were used as a data set. Carbon footprint calculations caused by electricity and natural gas consumption from fossil resources in sports facilities were carried out within the scope of Scope 1. In addition, it is frequently used in carbon footprint calculations due to the ease of access to the amount of energy consumed within the scope of Scope 1 and relatively simpler data sets. The total carbon footprint due to the amount of electricity consumed in sports facilities is calculated as 173,467 tonnes, while the carbon footprint due to natural gas consumption is calculated as 511,578.21 tonnes. In 2023, the total carbon footprint caused by the amount of energy consumed in sports facilities for a year is 685,045.21 tonnes. In this research where Ardahan is considered within the scope of case study, the results of carbon footprint from sports facilities can be attributed to 2 main reasons. The first one is climate conditions. The second one is the increase in participation in amateur and professional events and organisations held in sports facilities and the intensive use of sports facilities throughout the 12 months. As a case study, minimising the carbon footprint of sports facilities in Ardahan province and reducing their negative environmental impacts are very important in terms of sustainable environmental goals.
Keywords: carbon footprint, environment, sustainability, sports, sports facilitie.
Pengenalan Koperasi Syariah Dalam Mensejahterakan Perekonomian Umat
Authors: Miko Jeroh 
Published: December 2024

Koperasi syariah merupakan bentuk koperasi yang memiliki prinsip, tujuan, dan kegiatan usahanya berdasarkan syariah Islam, yaitu Al-quran dan As-sunah. Secara umum, koperasi ini merupakan badan usaha koperasi yang menjalankan aktivitas usahanya berdasarkan pada prinsip-prinsip syariah. Tujuan koperasi syariah harus sesuai dengan Maqashid Syariah yang fungsinya untuk melakukan dua hal penting, yaitu tahsil, yakni mengamankan manfaat (manfaah) dan ibqa, yaitu mencegah kerusakan atau cedera (madarrah) seperti yang diarahkan oleh Pemberi Hukum. Tujuan koperasi syariah yaitu mensejahterakan ekonomi anggotanya sesuai norma dan moral Islam, menciptakan persaudaraan dan keadilan sesama anggota, pendistribusian pendapatan dan kekayaan yang merata sesama anggota berdasarkan kontribusinya, kebebasan pribadi dalam kemaslahatan sosial yang didasarkan pada pengertian bahwa manusia diciptakan hanya untuk tunduk pada Allah, meningkatkan kesejahteraan anggota pada khususnya dan masyarakat pada umumnya serta turut membangun tatanan perekonomian yang berkeadilan sesuai dengan prinsip-prinsip Islam.
Pendampingan Pembuatan Sertifikasi Halal bagi UMKM di Desa Sidokaton Jombang
Authors: Mufarrihah Iftitaahul , Lazulfa Indana 
Published: December 2024

Perekonomian Indonesia pasca Covid 19 mulai berkembang pesat dengan ditandainya semakin banyaknya UMKM yang ada dimasyarakat. UMKM banyak menyerap tenaga kerja setelah adanya PHK saat Covid 19 melanda. Salah satu usaha yang dilakukan pemerintah untuk meningkatkan kualitas UMKM adalah dengan melakukan sertifikasi halal. Tujuan adanya sertifikasi halal ini adalah untuk meninkatkan keprcayaan masyarakat terhadap produk UMKM dan agar pelaku UMKM di Indonesia mampu bersaing di tingkat global. Sayangnya pengetahuan masyarakat tentang pentingnya sertifikasi halal ini masih sangat kurang, dan menganggap bahwa prosesnya sulit dan berbelit. Oleh karena itu diadakanlah pendampingan pembuatan sertifikasi halal pada UMKM yang ada di Desa Sidokaton agar para pelaku UMKM di desa tersebut dapat meningkatkan kualitas produk yan dihasilkan dan dapat bersaing dengan UMKM sejenis lainnya. Hasil kegiatan ini adalah semua UMKM yang ada di Desa Sidokaton sudah memiliki sertifikat halal. Kegiatan ini mendapatkan dukungan dan sambutan yang baik dari pemerintah desa maupun masyarakat sebanyak 85% menilai sangat membantu dan sisanya menilai baik dan cukup
Pocket Book Sebagai Sarana Pengelolaan dan Perencanaan Keuangan
Authors: Ardiana Meta , Pertiwi Dwi Ari , Agustina Rachma 
Published: December 2024

Setiap entitas hendaknya mengetahui berapa besar serapan biaya operasional usaha, berapa proyeksi profit yang terealisasi, serta berapa ekuitas yang dikelola untuk usaha. Sehingga dapat dijadikan alat evaluasi kemampuan dan kapasitas usaha sehingga dapat merancang strategi untuk pengembangan usahanya tersebut berdasarkan pencatatan keuangan yang telah dilakukan. Pengelolaan dan perencanaan keuangan bisa dimulai dengan disiplin melakukan pencatatan keuangan, pencatatan keuangan bisa dilakukan pada buku kecil (pocket book) maupun menggunakan aplikasi software dan gadget. Metode yang digunakan untuk memecahkan masalah terkait pengelolaan keuangan yakni melalui sosialisasi, ceramah, tutorial, pendampingan dan diskusi pengelolaan keuangan dengan pocket book di SMK Matsna Karim. Hasil pengabdian ini diketahui peserta mampu menyerap materi yang sampaikan dan antusias untuk menerapkan pencatatan keuangan dengan menggunakan pocket book. Penerapan pocket book ini diharapkan mampu meningkatkan pengelolaan keuangan pribadi maupun unit entitas. Dengan pencatatan keuangan secara rutin dan disiplin. Unit usaha dapat meningkatkan profit dan keunggulan bersaing.
Penguatan Ecopreneurship untuk Meningkatkan Minat Berwirausaha Pelajar
Authors: Falah Fajrul , Af’idah Noer , Rochim Roudhoutul Aulia , Musfiroh Anita 
Published: December 2024

Pelatihan ecopreneurship kepada siswa Madrasah Aliyah dilakukan sebagai salah satu upaya untuk mendukung pemerintah dalam menciptakan generasi muda yang memiliki jiwa entrepreneur yang tangguh. Adapun tujuan dari kegiatan pelatihan ini adalah untuk memberikan edukasi tentang wawasan kewirausahaan dan pengalaman kepada siswa dalam menghasilkan produk kewirausahaan berbasis lingkungan hidup. Kegiatan pengabdian ini dilaksanakan dengan melalui tiga tahap yaitu, tahap persiapan, tahap pelaksanaan, serta tahap refleksi dan tahap evaluasi. Kegiatan pelatihan ini dilaksanakan selama dua hari pada tanggal 23-24 April 2024 di MASS Khoiriyah Hasyim Seblak Jombang. Peserta kegiatan pelatihan adalah siswa kelas X dan XI IPA Putri sebanyak 31 orang. Hasil kegiatan ini menunjukkan bahwa sebanyak 83,87% peserta aktif selama mengikuti pelatihan; nilai ketrampilan dari pembuatan produk sebesar 82; dan skor minat berwirausaha sebesar 81,5.
Pelatihan Penerapan ISAK 35 Pada Panti Asuhan Pelita Harapan dan Penuh Pengharapan
Authors: Purba Sahala , Purba Kuras , Siahaan Septony B , Sitohang Santy Aji , Nababan Dame Tiur Magdalena 
Published: December 2024

Maksud dari pelatihan ini untuk mengembangkan panti asuhan dalam hal akuntabilitas maupun pelaporan keuangan sesuai dengan ISAK 35. Adapun metode yang digunakan dalam pelatihan ini adalah dengan cara wawancara terlebih dahulu lalu melakukan pelatihan pencatatan akuntansi sampai pelaporan keuangan sesuai dengan regulasi yang berlaku di Indonesia yaitu ISAK 35, dengan adanya pelatihan ini diharapkan panti asuhan dapat melakukan pertanggungjawaban atas sumbangan dari donatur. Pelatihan ini dilakukan selama 2 (dua) hari yaitu pada tanggal 8 dan 9 Desember 2023. Adapun hasil dari pelatihan ini adalah para pemilik panti asuhan merasa canggung karena selama ini mereka tidak mengetahui ada standar pelaporan keuangan khususnya untuk panti asuhan, karena mereka mencatat keuangannya hanya bentuk penerimaan kas dan pengeluaran kas saja, itupun dilakukan pada papan pengumuman yang ada dalam panti asuhan tersebut. Adapun yang menjadi implikasi dalam pelatihan ini adalah agar panti asuhan dapat berkelanjutan pada masa yang akan datang.
The risk factors and prediction model for postoperative pneumonia after craniotomy
Authors: Xiang Bingbing , Yi Mingliang , Li Chunyan , Yin Hong , Wang Shun , Liu Yiran 
Published: December 2024

BackgroundCraniotomy is highly susceptible to postoperative pneumonia, which significantly impacts the outcomes of patients undergoing such procedures. Our study aims to examine the risk factors associated with postoperative pneumonia and establish a predictive model with a nomogram to assess this risk.MethodsWe conducted a matched 1:1 case-control study involving 831 adult patients undergoing craniotomy at our hospital. Cases consisted of patients who developed postoperative pneumonia within 30 days after surgery, as defined by consensus criteria. Controls were randomly selected from a pool of eligible patients.ResultsThe overall incidence rate of postoperative pneumonia is 12.39% in a total of 831 surgeries, which associated with unfavorable outcomes. Gram-negative bacteria were found to be the most common causative agents and approximately 27.94% of cases attributed to multi-drug resistant strains. The logistic regression analysis revealed five independent risk factors, as follows: smoking history, surgical duration, postoperative albumin, unplanned re-operation, and deep vein catheterization. A risk prediction model was derived and a nomogram was constructed. The Hosmer-Lemeshow test yielded X2 = 3.871 (P=0.869), and the receiver operator characteristic curve analysis demonstrated an area under the curve of 0.898 (P&lt;0.05), with a sensitivity of 79.6% and a specificity of 85.4%, indicating excellent model fit and predictive performance. In addition, the C-index of the nomogram model was 0.898(95%CI, 0.853~0.941). The calibration curves of the nomogram model showed p-values of 0.797 and the Brier scores were 0.127. The analysis of the clinical decision curve showed that the nomograph model had high clinical application value.ConclusionsPostoperative pneumonia patients after craniotomy exhibits distinct pathogen distribution and is strongly associated with unfavorable outcomes. The risk prediction model developed in this study demonstrates a good fitting degree and predictive performance. The constructed nomogram model is objective, specific, and easily applicable in clinical practice.
Prevalence and predictors of poor heart failure treatment outcomes in Ethiopia: a systematic review and meta-analysis
Authors: Bekele Firomsa , Tafese Lalise , Fekadu Ginenus , Dube Geleta Nenko , Dugassa Dinka , Samuel Dagim 
Published: December 2024

BackgroundHeart failure (HF) is a leading cause of morbidity and mortality worldwide. Various factors can exacerbate disease progression in patients with HF and negatively impact treatment outcomes. This study aims to evaluate the pooled prevalence and contributing factors associated with poor heart failure treatment outcomes in Ethiopia.MethodsA systematic review and meta-analysis were conducted using five databases: Google Scholar, ScienceDirect, Hinari, PubMed, and Scopus. In total, 12 studies met the eligibility criteria for inclusion in this analysis. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. Data extraction was performed using a Microsoft Excel spreadsheet, and statistical analysis was conducted with STATA 14. The Joanna Briggs Institute Meta-analysis of Statistics Assessment and Review Instrument was utilized for quality assessment. Heterogeneity among the studies was evaluated using the I2 statistic and the Cochrane Q test. Publication bias was assessed using Begg's test, Egger's weighted regression, and funnel plots.ResultsThe pooled prevalence of poor HF treatment outcomes was found to be 16.67% [95% confidence interval (CI): 10.67–22.67]. No significant heterogeneity was observed across the included studies (I2 = 0.0%, p = 0.962). Significant predictors of a poor treatment outcome were smoking cigarettes [adjusted odds ratio (AOR) = 10.74; 95% CI: 3.24–35.63] and medication-related problems (AOR = 3.99; 95% CI: 1.90–8.37).ConclusionThe prevalence of poor HF treatment outcomes in Ethiopia was found to be high. Smoking cigarettes and medication-related problems are significant predictors of these adverse outcomes. Comprehensive health education and improved clinical pharmacy services are essential for addressing these issues.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023437397, PROSPERO (CRD42023437397).
VA-ECOM assisted percutaneous mechanical thrombectomy treatment high-risk pulmonary embolism
Authors: Zhou Zhenhang , Zhong Yaoyang , Hu Jianbo , Wu Zhonghua , Zou Liping , Deng Zhihe , Bi Guoshan , Shen Xin , Dai Xianpeng , Huang Zhijia , Xiong Guozuo , Xu Yiming , Deng Liming 
Published: December 2024

BackgroundPercutaneous mechanical thrombectomy (PMT) is increasingly used in the treatment of intermediate and high-risk acute pulmonary embolism (PE), and the treatment of high-risk PE with the aid of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has also been reported. However, there are few reports of VA-ECOM-assisted PMT in the treatment of high-risk PE. The purpose of this study is to summarize the data of 11 patients with high-risk PE treated with VA-ECMO assisted PMT, and propose feasible treatment methods for such patients.MethodsThis multicenter retrospective study included patients with acute high-risk PE who were treated with VA-ECMO-assisted PMT from January 2021 to June 2024. The analysis focused on the right/left ventricle ratio, biomarkers, and pulmonary artery pressure before and after the VA-ECMO-assisted PMT treatment.ResultsAll 11 high-risk PE patients suffered cardiac arrest before treatment, computered tomograhy pulmonary angiography (CTPA) confirmed the diagnosis of PE, and all patients received VA-ECMO-assisted PMT therapy. The median age of the 11 patients was 54 years (range 18–72), the median duration of ECMO was 4.48 days (range 1.04–18.02), and the mean hospitalization time was 21 days (range 14–112). All patients received percutaneous thrombectomy, achieving a 100% technical success rate. The mortality rate was 27.3% during the 90-day follow-up. The 12-month mortality rate was 36.4%.ConclusionVA-ECMO-assisted PMT technology can rapidly improve pulmonary hemodynamics while maintaining stable blood flow, thereby reducing in-hospital mortality in high-risk patients with pulmonary embolism complicated by cardiac arrest.
Measurement and optimization of sustainable urban form elements in New Urban districts using multi-source data
Authors: Zhang Yanfeng , Wang Xiaohui , Wang Longsheng , Li Guangyu , Zhang Yige , Ye Yu , Jiang Hongqiang , Zhong Shaoyun , Song Junxi 
Published: December 2024

IntroductionAt the crucial stage of China’s transition from extensive expansion driven by external factors to intensive, connotation-focused development, scientifically optimizing the spatial form of new urban districts, promoting dynamic and adaptive spaces, and enhancing the quality and diversity of urban environments are issues of substantial importance.MethodsBased on urban morphology, this study proposes that high street accessibility, appropriate building density and typology, and a sufficient degree of functional mixing are the foundations of spatial morphology for promoting sustainable urban development. Using spatial syntax, a spatial matrix, and mixed-function indices, this study measures urban spatial morphology elements and explores differences and rhythms in sustainable spatial morphology in new urban districts with varying development functions and cycles.ResultsThe results of the study show that: 1) the overall synergy of the accessibility spatial network in the new urban districts of Yinzhou and Xianlin is high. The building typology was dominated by mid-rise slab and enclosed types, low-rise enclosed types, and high-rise slab types, while the multistory high-coverage forms were interspersed with intervals. 2) Development in new urban districts primarily adopted a large land plot development mode with a single function. The degree of multifunctional mixing was observed to be relatively low. The dual-functional mixing degree in the Yinzhou New Urban District is higher than that in the New Xianlin urban district. 3) A significant level of overlap was observed among functional mixing, accessibility, building density, and typology. Of the functional mixing units, 42.41% of the dual-function and 78.57% of multi-function types were clustered in high-value areas of urban vitality. Additionally, 50.25% of dual-function and 85.71% of multi-function units were aggregated in high-accessibility areas.DiscussionThe mixed-use of sites contributes to the creation of urban vitality and sustainability, and the effect of the correlation between mixed-functionality and accessibility is more pronounced when mixed units involve utility land. The research results provide a reference for evaluating the current sustainable challenges of spatial patterns and offer specific tools for optimizing new urban districts.
Tradeoffs between thinning treatments and rotation periods of planted Larix olgensis forests: a perspective from carbon balance
Authors: Lin Xueying , Lu Wei , Dong Lingbo 
Published: December 2024

IntroudctionThe current CO2 levels are higher than ever in the past two million years. Forests, as one of the climate change mitigation solutions, are becoming increasingly technically feasible and cost-effective. However, limited research comprehensively considers thinning in the context of optimizing the rotation period for carbon sequestration.MethodsThis study utilizes stand-level growth models and diameter distribution models to simulate the carbon balance dynamics of Larch (Larix olgensis) plantations under various thinning scenarios. The effects of different initial planting densities (N0∈{2,500, 3,333, 4,444} tree ha−1) and site class index (SCI∈[14–20] m) on the optimal forest management measures are also quantified.ResultsThe results reveal that the overall trend of carbon balance gradually increases and then decreases over time under the baseline scenario (3,333 tree ha−1 of N0, 16 m of SCI, 5% of discount rate, 100 CNY ton−1 C of carbon price); the carbon balances of all thinning forests were less than that of the unthinned forest before until 56th year. The optimal rotation period and net present value (NPV) increase with increasing thinning frequency and intensity. The sensitivity of NPV to thinning frequency increases with higher thinning intensities, SCI, and carbon prices.DiscussionThis study further expands the scope of forest management strategies, providing optimal forest management plans for all 21 combinations of different SCIs and N0. The optimal forest management strategy in the baseline scenario is 3 thinnings, with the first thinning at 20% intensity in the 15th year, the second thinning at 30% intensity in the 18th year, and the third thinning at 30% intensity at 21 years, with a rotation period of 26 years, resulting in an NPV of 37,180 CNY ha−1.
Optimized BCMA/CS1 bispecific TRuC-T cells secreting IL-7 and CCL21 robustly control multiple myeloma
Authors: Li Min , Zheng Rong , Liu Zairu , Zhang Peiyuan , Zhu Tingwei , Xin Xueyi , Zhao Hongli , Chen Wenyi , Zheng Binjiao , Zhao Ai , Gao Jimin 
Published: December 2024

IntroductionChallenges remain in reducing antigen escape and tumor recurrence while CAR-T cell therapy has substantially improved outcomes in the treatment of multiple myeloma. T cell receptor fusion construct (TRuC)-T cells, which utilize intact T cell receptor (TCR)-CD3 complex to eliminate tumor cells in a non-major histocompatibility complex (MHC)-restricted manner, represent a promising strategy. Moreover, interleukin-7 (IL-7) is known to enhance the proliferation and survival of T cells. C-C motif chemokine ligand 21 (CCL21) is a ligand for chemokine C-C motif receptor 7 (CCR7) and exhibits strong chemotaxis against naïve T cells and antigen-presenting cells such as dendritic cells.MethodsThe bispecific TRuC-T cells simultaneously targeting B cell maturation antigen (BCMA) and CD2 subset 1 (CS1) were constructed by pairing two of five subunits (i.e., TCRαC, TCRβC, CD3γ, CD3δ, and CD3ϵ) in the TCR/CD3 complex and were named C-AC-B-3E, C-BC-B-3E, C-3G-B-3E, C-3D-B-3E, C-3E-B-3E, B-3E-C-3E, B-3G-C-3E, and B-3D-C-3E. Additionally, the BCMA/CS1 bispecific TRuC-T cells secreting IL-7 and CCL21, named BC-7×21 TRuC-T cells, were generated. All of the bispecific TRuC-T cells were characterized and tested in vitro and in vivo.ResultsFollowing the optimization of various pairs of two subunits of TCR/CD3 complex, B-3G-C-3E TRuC-T cells, characterized by incorporating CD3γ and CD3ε, exhibited the strongest myeloma-specific cytotoxicity. Furthermore, the bispecific BC-7×21 TRuC-T cells had stronger proliferation, chemotaxis, and cytotoxicity in vitro. Accordingly, the bispecific BC-7×21 TRuC-T cells showed better persistence in vivo so as to effectively suppress tumor growth in the NCG mouse xenograft model of MM.1S multiple myeloma.DiscussionThis study demonstrated that BC-7×21 TRuC-T cells, engineered through the optimization of the two subunits of TCR/CD3 complex and a co-expression cytokine strategy, may offer a novel and effective therapy for relapsed/refractory multiple myeloma.
CD28 shapes T cell receptor signaling by regulating Lck dynamics and ZAP70 activation
Authors: Raychaudhuri Kumarkrishna , Rangu Rohita , Ma Alison , Alvinez Neriah , Tran Andy D. , Pallikkuth Sandeep , McIntire Katherine M. , Garvey Joseph A. , Yi Jason , Samelson Lawrence E. 
Published: December 2024

IntroductionT cell activation requires T cell receptor (TCR) engagement by its specific ligand. This interaction initiates a series of proximal events including tyrosine phosphorylation of the CD3 and TCRζ chains, recruitment, and activation of the protein tyrosine kinases Lck and ZAP70, followed by recruitment of adapter and signaling proteins. CD28 co-stimulation is also required to generate a functional immune response. Currently we lack a full understanding of the molecular mechanism of CD28 activation.MethodsWe employed TIRF microscopy to establish detailed spatial and kinetic relationships among these molecules in live Jurkat and murine primary T cells. We used anti-TCR (CD3) antibodies to trigger formation of TCR microclusters (MC), which are submicron-sized basic signaling units formed during T cell activation. Using this model, we aimed to delineate how the CD28 co-stimulatory signal alters the kinetics and molecular stoichiometry of TCR proximal signaling events, and how these effects could affect the immune response.ResultsOur results show that CD28 co-stimulation specifically accelerated recruitment of ZAP70 to the TCRζ chain in MCs and increased ZAP70 activation. CD28-mediated acceleration of ZAP70 recruitment was driven by enhanced Lck recruitment to the MCs. A greater spatial separation between active and inactive species of Lck was also observed in the MCs as a consequence of CD28 co-stimulation.ConclusionThese results suggest that CD28 co- stimulation may lower the TCR activation threshold by enhancing the activated form of Lck in the TCR MCs.