bluuebunny/crossref_metadata_2025_split huggingface dataset:
Undesirable effects and persistence of gliflozine treatment in patients with type 2 diabetes mellitus
Authors: De Mori, v.  
Published: May 2021

OBJECTIVE OF THE STUDY SIDECAR (SGLT2-Inhibitors in Diabetes: Evaluation of metabolic Control and Adverse events in the Real-world), is a monocentric prospective observational study performed to monitoring in clinical practice patients with type 2 diabetes (T2D) treated with SGLT2-i to evaluate metabolic and anthropometric evolution during time, as well as the onset of adverse effects (AEs). Design and methods. Demographic features, T2D duration, and clinical parameters at baseline have been recorded as mean ± Standard Deviation (SD) for continuous variables, and frequency distribution for discrete variables. A repeated measures regression model was utilized for the evolution during time of parameters. AEs prevalence were recorded with stratification for main clinical and demographic features at baseline. RESULTS N=220 patients, with 18 months available follow-up, treated with SGLT2-i (N= 19 canagliflozin, 8.6%; N=91 dapagliflozin, 41.4%; N=110 empagliflozin, 50%) monotherapy or in combination according to AIFA indications). Really effective was the action of SGLT2-i on glucose metabolism, with rapid reduction in HbA1c and fasting plasma glucose after 6 months, as well as after 12 and 18 months (HbA1c: -1,0%; fasting plasma glucose: -34,8mg/dL). Weight and BMI showed a satisfying improvement, while waist circumference was statistically significant only after 12 months. Blood pressure, total cholesterol, and renal function were not modified by the treatment. But, apart from the valuable effects on metabolic parameters, 86 patients (39%) suspended SGLT2-i treatment mainly because ineffectiveness (15,7%) or for Genito-Urinary Tract Infections (GUTIs) appearance (14,3%). CONCLUSIONS Median term follow-up confirms the efficacy of SGLT2-i, but a significant percentage of patients is forced to suspend these drugs especially for GUTIs appearance. Such high prevalence of non-serious AEs limits the potential nephro-cardiovascular benefits related to SGLT2-i utilization. A possible chance to reduce GUTIs should come from single tablet association of SGLT2-i and DPP4-i actually available on the market. KEY WORDS type 2 diabetes; SGLT2 inhibitors; genito-urinary tract infections; real world evaluation; health education
Видовий склад і таксаційні характеристики деревних рослин санітарно-захисної зони Придніпровського ремонтно-механічного заводу
Authors: Бессонова В. П. , Чонгова А. С. 
Published: May 2021

Досліджено деревні насадження санітарно-захисної зони (СЗЗ) Придніпровського ремонтно-механічного заводу міста Дніпро. Проаналізовано видове різноманіття, деякі таксаційні показники; проведено розподіл дерев за відношенням до рівня зволоження та комплексне оцінювання життєвого стану деревостану СЗЗ Придніпровського ремонтно-механічного заводу. Для оцінювання життєвого стану рослин та індексу стану деревостану використано шкалу В. А. Алексєєва (1989). Охарактеризовано планувальну структуру санітарного насадження. Встановлено, що дендрофлора цієї санітарно-захисної зони представлена 19 видами деревних порід та однією формою, котрі належать до 10 родин. З них 11 видів є інтродукованими та 8 – аборигенними. Виявлено, що найбільше таксономічне представництво має родина Salicaceae – 6 видів (35,4 % від загального числа дерев у насадженні). З'ясовано, що більшість родин презентовані тільки одним видом. Відзначено, що з хвойних порід на досліджуваній території росте тільки Pinus pallasiana D. Don. Виявлено, що 31,6 % усіх видів представлені тільки 1-3 екземплярами. Розраховано індекс біорізноманітності Шенона (Н), який становить 3,55. З'ясовано, що найбільша кількість дерев має висоту в межах 12-13 м (18,9 % від загального числа дерев в насадженні) і діаметр стовбурів від 26,0 до 29,9 см та від 38,0 до 41,9 см (по 8,8 %). Розподіл дерев за відношенням до умов зволоження показав, що більшість деревних рослин є ксерофітами (40,0 % від загальної чисельності рослин), що відповідає умовам степового регіону. Значну частину рослин віднесено до мезогігрофітів та гігрофітів (29,0 та 12,5 % відповідно), що можна пояснити наявністю природної водойми. Встановлено, що категорії стану "здорові" відповідає 37,9 % від загальної кількості, до помірно ослаблених – 47,3 % (друга категорія життєвого стану). Найбільш стійкими виявились Salix alba L. та Robinia pseudoacacia L., у найбільш непривабливому стані перебувають Populus nigra L. та Aesculus hippocastanum L. З'ясовано, що індекс життєвого стану деревних рослин захисної зони дорівнює 75,6 % і характеризується як ослаблений.
Pengaruh Sosialisasi Terhadap Kepatuhan Warga dalam Membayar Kewajiban Pajak Bumi dan Bangunan di Desa Solokan Jeruk Kabupaten Bandung
Authors: Rahmadianti  , Ahmad Saepudin  
Published: May 2021

Penelitian ini dilakukan di Desa Solokan Jeruk Kabupaten Bandung dengan tujuan untuk mengetahui tingkat sosialisasi, kepatuhan dan besarnya pengaruh sosialisasi terhadap kepatuhan warga dalam membayar kewajiban pajak bumi dan bangunan. Metode penelitian yang digunakan adalah penelitian survey dengan pendekatan kuantitatif. Populasi dalam penelitian ini sebanyak 1.419 orang. Teknik pengambilan sampel yang digunakan dalam penelitian ini adalah probability sampling berupa simple random sampling. Dengan menggunakan rumus dari Slovin dan taraf kesalahan (e) sebesar 10%, maka jumlah sampel yang diambil sebanyak 93 orang. Teknik analisis data yang digunakan adalah teknik analisis korelasi Product Moment dan analisis regresi sederhana. Berdasarkan pada hasil pengujian hipotesis, menunjukkan bahwa sosialisasi perpajakan memiliki pengaruh yang signifikan terhadap kepatuhan.
Gymnastics Improve Quality Of Life
Authors: Wahyuni Endang Sri , Arifiati Retna Febri 
Published: May 2021

ABSTRACT
Background: The increase in the number of elderly people needs to be balanced with increased expectations and quality of life. One of the causes of the low quality of life of the elderly is influenced by a lack of physical activity. Efforts that can be made to improve the quality of life of the elderly are by doing physical activity or exercising regularly. This study aims to determine the effect of physical activity on the quality of life of the elderly.
Methods: This type of research is quantitative, pre-experimental with one group pretest-posttest design, using purposive sampling technique. The research instrument was the WHOQOL-BREF questionnaire. The research subjects were 30 people. Data analysis used the Wilcoxon test.
Results: As many as 80% of the subjects were in the age range 66-74 years, 26 subjects were women (53.3%), the latest education was dominated by Bachelor 43.4%. As many as 76.7% are retired civil servants, 70% still have a partner, 26.7% live with a partner and children, and 66.7% are healthy elderly without a history of disease. The results show a positive value and an increase in the mean in each domain. The asymptotic significance values of the pre-post Wilcoxon ranking test on the domain of physical and environmental conditions were 0.000 and 0.003 on psychological conditions and social relationships.
Conclusion: The provision of physical activity interventions in the form of flexible exercise for the elderly has a significant impact on improving the quality of life of the elderly.
Spatial association between platinum minerals and magmatic sulfides imaged with the Maia Mapper and implications for the origin of the chromite-sulfide-PGE association
Authors: Barnes Stephen J. , Ryan Chris , Moorhead Gareth , Latypov Rais , Maier Wolfgang D. , Yudovskaya Marina , Godel Bélinda , Schoneveld Louise E. , Le Vaillant Margaux , Pearce Mark B. 
Published: May 2021

ABSTRACT
The spatial association between Pt minerals, magmatic sulfides, and chromite has been investigated using microbeam X-ray fluorescence (XRF) element mapping and the Maia Mapper. This lab-based instrument combines the Maia parallel energy dispersive (ESD) detector array technology with a focused X-ray beam generated from a liquid metal source. It proves to be a powerful technique for imaging Pt distribution at low-ppm levels on minimally prepared cut rock surfaces over areas of tens to hundreds of square centimeters, an ideal scale for investigating these relationships. Images of a selection of samples from the Bushveld Complex and from the Norilsk-Talnakh ore deposits (Siberia) show strikingly close association of Pt hotspots, equated with the presence of Pt-rich mineral grains, with magmatic sulfide blebs in all cases, except for a taxitic low-S ore sample from Norilsk. In all of the Bushveld samples, at least 75% of Pt hotspots (by number) occur at or within a few hundred microns of the outer edges of sulfide blebs. In samples from the leader seams of the UG2 chromitite, sulfides and platinum hotspots are also very closely associated with the chromite seams and are almost completely absent from the intervening pyroxenite. In the Merensky Reef, the area ratio of Pt hotspots to sulfides is markedly higher in the chromite stringers than in the silicate-dominated lithologies over a few centimeters either side. We take these observations as confirmation that sulfide liquid is indeed the prime collector for Pt and, by inference, for the other platinum group elements (PGEs) in all these settings. We further propose a mechanism for the sulfide-PGE-chromite association in terms of in situ heterogeneous nucleation of all these phases coupled with transient sulfide saturation during chromite growth and subsequent sulfide loss by partial re-dissolution. In the case of the amygdular Norilsk taxite, the textural relationship and high PGE/S ratio is explained by extensive loss of S to an escaping aqueous vapor phase.
STRATEGY FOR RESUMING ELECTIVE SURGICAL PROCEDURES DURING & AFTER COVID-19 PANDEMIC
Authors: Khan Muhammad Iqbal , Shabir Ahmed Lehri  , Riffat Arbab  
Published: May 2021

ABSTRACT
COVID-19 pandemic has afflicted the individuals, national economies, and healthcare system worldwide. It has badly struck the ongoing and planned surgical procedures in nearly all healthcare centers which has led the surgical procedures to come to a grinding halt. This serious issue invites comments from surgical experts throughout the world.
Pengaruh E-Module Speaking Berbasis Website Untuk Meningkatkan Keterampilan Berbicara
Authors: Setyawan Wawan Herry , Nawangsari Tantin 
Published: May 2021

<p>Tujuan dari penelitian ini adalah 1) untuk mengetahui kelayakan e-modul untuk meningkatkan keterampilan berbicara peserta didik dan 2) untuk mengetahui keefektifan e-modul untuk meningkatkan keterampilan berbicara peserta didik. Penelitian ini merupakan penelitian pengembangan dengan desain Research &amp; Development (R&amp;D) dengan pendekatan Borg &amp; Gall. Tahapan yang dilakukan dalam tujuh tahap yaitu: 1) Penelitian dan Pengumpulan Informasi, 2) Perencanaan, 3) Pengembangan Bentuk Produk Asli, 4) Pengujian Bidang Awal Produk, 5) Revisi Produk Awal untuk Menghasilkan Produk Utama, 6) Menguji Bidang Produk Utama, dan 7) Revisi Produksi Utama Menghasilkan Produk Operasional. Hasil penelitian menunjukkan bahwa dari penilaian para ahli diperoleh hasil pengukuran 92% dengan kategori nilai 81% -100% valid. Hal tersebut menunjukkan bahwa modul e-learning sangat sesuai untuk proses belajar mengajar sebagai hasil evaluasi pre-test dan post-test. Nilai rata-rata hasil belajar pada Pre Test 70,00 &lt;Post Test 90,00, nilai Sig. (2-tailed) adalah 0,000 &lt;0,05, maka H0 ditolak dan Ha diterima. Sehingga dapat disimpulkan bahwa aplikasi e-modul Speaking on website by (Zoom) sangat berpengaruh dan efektif untuk diterapkan dalam sistem pembelajaran online di Kampung Course Pare-Kediri.</p><p>The aimed of this research was 1) to know the feasibility of e-Module to improve learners’ speaking skill. This research was a development research using Research &amp; Development (R&amp;D) design by using Borg &amp; Gall approach. The stages were carried out in seven steps such as: 1) Research and Information Collection, 2) Planning, 3) Developing the Original Product Form, 4) Testing The Field of Product Scratch, 5) Initial Product Revision to Produce the Main Product, 6) Test The Main Product Field, and 7) Major Production Revisions Produce Operational Products. The result showed that from assessment by experts, the measurement results were 92% with a category value of 81% -100% valid. It showed that the e-learning module was very suitable for the teaching and learning process as the result of the pre-test and post-test evaluations. The average value of learning outcomes on the Pre Test 70.00 &lt;Post Test 90.00, the value of Sig. (2-tailed) is 0.000 &lt;0.05, then H0 is rejected and Ha is accepted. So, it can be concluded that the e-module Speaking on website by (Zoom) application was very influential and effective to be applied in the online learning system at Kampung Course Pare-Kediri. </p>
Pengaruh Kepemimpinan Karismatik Dan Kompetensi Kepribadian Guru Terhadap Disiplin Kerja Guru
Authors: Holilah Lilah , Fatmasari Rhini , Rosita Tita 
Published: May 2021

<p>Penelitian ini bertujuan untuk menganalisis pengaruh kepemimpinan karismatik dan kompetensi kepribadian terhadap disiplin kerja guru sekolah dasar. Data dianalisis dengan menggunakan statistic deskriptif dan inferensial yaitu SEM dan analisis jalur (metode simultan yaitu uji-F). Hasil penelitian menunjukkan bahwa: (1) Kepemimpinan Karismatik berpengaruh signifikan dan positif diterima terhadap disiplin kerja guru, hal ini dapat dibuktikan dengan T<sub>hitung </sub>&gt;T<sub>tabel </sub>(3,49&gt;1,97) dan nilai koefisien loading faktor sebesar 0,33; (2) kompetensi kepribadian guru berpengaruh signifikan dan positif diterima, hal ini dapat dibuktikan dengan T<sub>hitung </sub>&gt;T<sub>tabel </sub>(6,67&gt;1,97) dan nilai koefisien loading faktor 0,65; (3) hasil uji bersama-sama kepemimpin karismatik dan kompetensi kepribadian guru berpengaruh signifikan terhadap disiplin kerja guru, hal ini dapat dibuktikan dengan F hitung sebesar 5.155, nilai prob&lt;alpha (0.007&lt;5%), dan nilai R-square sebesar 51,44% sudah baik karena memiliki nilai lebih dari 50%. Dapat disimpulkan bahwa kepemimpinan karismatik dan kompetensi kepribadian guru yang baik memiliki tingkat disiplin kerja guru yang tinggi.</p><p><em>The research aims to analyze the influences charismatic leadership and personality competence of teacher towards the discipline of work of states elementary teacher. The primary data were analyzed by using descriptive and inferential statistics that is SEM and path analysis (simultan method that is uji-F). The result showed that: Firt, charismatic leadership significant influence and be accepted positively on the discipline of work of states elementary teacher, this was proved by T<sub>hitung </sub>&gt;T<sub>tabel </sub>(3,49&gt;1,97) and factor loading coefficient value equal to 0,33. Secondly, personality competence of teacher significant influence and be accepted positively on the discipline of work of states elementary teacher, this was proved by T<sub>hitung </sub>&gt;T<sub>tabel </sub>(6,67&gt;1,97) dan factor loading coefficient value equal to 0,65. Third, the test results together charismatic leadership and personality competence of teacher towards the discipline of work of states elementary teacher, this was proved by F hitung amounting to 5.155, prob score&lt;alpha (0.007&lt;5%), dan R-square equal to 51,44% is good because it has a value of more than 50%. So it can be concluded that charismatic leadership and good teacher personality competence have a high level of teacher work discipline.</em></p>
Coaque: An Astronomical Icon in the Middle of the World*
Authors: Vásquez Nicolás A. , Erazo Cristopher , Domínguez Diego , Caiza Ricardo 
Published: May 2021

Abstract
This study aims to contribute to the astronomical studies for the creation of the astronomical and archaeological museum in Ecuador. Coaque, a fishermen village in the north coastal of Ecuador, is an iconic place where astronomy and archeology converge and portrays the geodesic and astronomical history of Ecuador. The 16th Century ethnohistorical data is rich on descriptions about abundance of wealth and land fertility within equinoctial zones. This awoke the curiosity of Europeans on the geodesic position. Two centuries later, La Condamine and Bouguer of the French-Hispanic Geodesic Mission, first measured the zero-degrees latitude at Punta Palmar, just south of Coaque. We present the detectability of the Crab Nebula, a high energy TeV source revealing the potential for astroparticles field of study. Also, we clarified the wrong idea of the equilibrium of an egg at zero latitude, a popular misinterpreted physical phenomenon.
Quelques aspects des rapports entre la franc-maçonnerie et la sphère politique en Haïti au XIX e siècle
Authors: Clorméus Lewis Ampidu 
Published: May 2021

Très peu d’études scientifiques concernent l’histoire de la franc-maçonnerie en Haïti. Pourtant, particulièrement au xix e siècle, cette association a eu une influence considérable sur la vie sociale et politique du pays. Par tradition, la plupart des hommes d’Etat haïtiens ont fréquenté des loges maçonniques qui, bien que se rejoignant autour de certains principes idéologiques, se sont souvent opposées sur le plan politique. En conséquence, la franc-maçonnerie peut être considérée comme un espace de sociabilité et de pouvoir pour les élites politiques d’Haïti.
L’ESS existe-t-elle ?   Des approches institutionnelles aux initiatives solidaires de proximité
Authors: Astier Karine 
Published: May 2021

Cet article a été écrit durant l’année 2019, en master ids essap . Lorsque je me suis assise sur les bancs de l’université, j’avais une représentation idéaliste et simpliste de l’ ess : une démarche sociétale innovante axée sur une économie solidaire. La chute de mes représentations a été un peu brutale et la vision s’est quelque peu confrontée à une réalité moins idéale, avec des définitions institutionnelles, une histoire politique. La frontière entre l’économique et le social reste floue.
Prevalence and factors associated with non-adherence to multi-drug resistant tuberculosis (MDR-TB) treatment at Mulago National Referral Hospital, Kampala, Uganda
Authors: Batte Charles , Namusobya Martha S , Kirabo Racheal , Mukisa John , Adakun Susan , Katamba Achilles 
Published: May 2021

Background: In Uganda, 12% of previously treated TB cases and 1.6% of new cases have MDR-TB and require specialized treatment and care. Adherence is crucial for improving MDR-TB treatment outcomes. There is paucity of information on the extent to which these patients adhere to treatment and what the drivers of non-adherence are.
Methods: We conducted a cohort study using retrospectively collected routine program data for patients treated for MDR- TB between January 2012 – May 2016 at Mulago Hospital. We extracted anonymized data on non-adherence (missing 10% or more of DOT), socio-economic, demographic, and treatment characteristics of the patients. All participants were sen- sitive to MDR-TB drugs after second line Drug Susceptible Testing (DST) at entry into the study. Factors associated with non-adherence to MDR-TB treatment were determined using generalized linear models for the binomial family with log link and robust standard errors. We considered a p- value less than 0.05 as statistically significant.
Results: The records of 227 MDR- TB patients met the inclusion criteria, 39.4% of whom were female, 32.6% aged be- tween 25 – 34 years, and 54.6% living with HIV/AIDS. About 11.9% of the patients were non-adherent. The main driver for non-adherence was history of previous DR-TB treatment; previously treated DR-TB patients were 3.46 (Adjusted prev- alence ratio: 3.46, 95 % CI: 1.68 - 7.14) times more likely to be non-adherent.
Conclusion: One in 10 MDR-TB patients treated at Mulago hospital is non-adherent to treatment. History of previous DR- TB treatment was significantly associated with non-adherence in this study. MDR-TB program should strengthen adherence counselling, strengthen DST surveillance, and close monitoring for previously treated DR-TB patients.
Keywords: Non-adherence; multi-drug resistant tuberculosis; treatment.
Role of miR-134 in angiotensin II-induced vascular cell pathological changes in atherosclerosis
Authors: Chen Jing , Hu Qi , Zhang Bofang , Liu Xiaopei , Yang Shuo , Jiang Hong 
Published: May 2021

Purpose: To investigate the role of miR-134 in vascular smooth muscle cell dysfunction-related cardiovascular disease.
Methods: The effect of miR-134 was evaluated after human aortic smooth muscle cells (HASMCs) were transfected with miR-134 mimics. The expression levels of p-Akt, mechanistic target of rapamycin (mTOR), cleaved caspase-3, p53, and β-actin were evaluated by immunoblotting. Terminal deoxynucleotidyl transferase dUTP nick-end labeling was used to measure cell apoptosis. Reactive oxygen species levels were assayed by fluorescence microscopy after staining with 2’,7’– dichlorofluorescein diacetate.
Results: Angiotensin II treatment induced miR-134 expression and Akt/mTOR activation, and inhibited cell viability in HASMCs (p < 0.01). Co-treatment with miRNA-134 reversed Ang II-induced HASMC dysfunction (p < 0.01). Overexpression of miR-134 is protective in Ang II-induced oxidative stress and apoptosis via the Akt/mTOR pathway (p < 0.05).
Conclusion: MicroRNA-134 in HASMCs is a potential therapeutic target for preventing Ang II-induced cardiac dysfunction via modulating Akt/mTOR pathway.
Rancang Bangun Modul Praktikum Penggunaan Bipolar Junction Transistor Sebagai Sakelar Berbasis Arduino Mega
Authors: Kusuma Zeka Wijaya , Pradana Sunu , Kurniawan Abdul Hamid 
Published: May 2021

Abstrak- BJT (Bipolar Junction Transistor) sebagai sakelar adalah salah satu pokok bahasan pada mata kuliah elektronika daya dan membutuhkan modul praktikum sebagai media dalam proses pembelajarannya. Modul praktikum yang sudah ada relatif kompleks sehingga penulis membuat rancang bangun yang lebih sederhana sehingga mudah untuk diperbaiki saat terjadi kerusakan serta komponen penggantinya mudah untuk ditemukan. BJT dapat berfungsi sebagai sakelar dengan memanfaatkan dua modenya yaitu saturation dan cut off. Pada perancangan modul, penyakelaran dikendalikan oleh Arduino Mega dengan sinyal PWM (Pulse Width Modulation) pada terminal basis, baik BJT NPN maupun BJT PNP. Berdasarkan pengujian saat cut off untuk BJT NPN dan BJT PNP pada beban resistor maupun resistor dengan induktor, nilai tegangan beban 0 V dan arus beban 0,003 A. sedangkan saat saturation pada beban resistor untuk BJT NPN, nilai tegangan beban 11,45 V dan arus beban 0,572 A dan BJT PNP, nilai tegangan beban 11,45 V dan arus beban 0,573 A. pada beban resistor dengan induktor untuk BJT NPN, nilai tegangan beban 11,81 V dan arus beban 0,122 A dan BJT PNP, nilai tegangan beban 11,79 V dan arus beban 0,121 A.