bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between health IT characteristics and organizational variables among German healthcare workers
Authors: Gaube Susanne , Cecil Julia , Wagner Simon , Schicho Andreas 
Published: May 2021

Abstract
Health information technologies (HITs) are widely employed in healthcare and are supposed to improve quality of care and patient safety. However, so far, their implementation has shown mixed results, which might be explainable by understudied psychological factors of human-HIT interaction. Therefore, the present study investigates the association between the perception of HIT characteristics and psychological and organizational variables among 445 healthcare workers via a cross-sectional online survey in Germany. The proposed hypotheses were tested using structural equation modeling. The results showed that good HIT usability was associated with lower levels of techno-overload and lower IT-related strain. In turn, experiencing techno-overload and IT-related strain was associated with lower job satisfaction. An effective error management culture at the workplace was linked to higher job satisfaction and a slightly lower frequency of self-reported medical errors. About 69% of surveyed healthcare workers reported making errors less frequently than their colleagues, suggesting a bias in either the perception or reporting of errors. In conclusion, the study’s findings indicate that ensuring high perceived usability when implementing HITs is crucial to avoiding frustration among healthcare workers and keeping them satisfied. Additonaly healthcare facilities should invest in error management programs since error management culture is linked to other important organizational variables.
Optimal Photon Energy Transfer on Titanium Targets for Laser Thrusters
Authors: Marcu Aurelian , Stafe Mihai , Mihail-Gabriel Barbuta , Razvan Ungureanu , Serbanescu Mihai , Calin Bogdan , Nicolae Puscas 
Published: May 2021

Abstract
Using two infrared pulsed lasers systems: a picosecond solid-state Nd:YAG laser with tunable repetition rate (400 kHz - 1MHz) working in a burst mode of multi-pulse train and a femtosecond Ti:Sapphire laser amplifier with tunable pulse duration inthe range of tens of femtoseconds up to tens of picoseconds, working in single-shot mode (TEWALASS facility from CETAL-NILPRP), we have investigated the optimal laser parameters for kinetic energy transfer to a titanium target for laser-thrustapplications. In the single-pulse regime, we controlled the power density by changing both duration and pulse energy. Inthe multi-pulse regime, the train’s number of pulses (burst length), and the pulse energy variation were investigated. Heatpropagation and photon reflection-based models were used to simulate obtained experimental results. In the single-pulseregime, optimal kinetic energy transfer was obtained for power densities of about 500 times the ablation threshold correspondingto the specific laser pulse duration. In multi-pulse regimes, the optimal number of pulses per train increases with the trainfrequency and decreases with the pulse power density. An ideal energy transfer efficiency resulting from our experiments andsimulations is close to around 0.02%.
Global Profiling of Lysine Crotonylation in Vascular Smooth Muscle Cell Phenotypic Remodeling
Authors: Cao Shan-hu , Yue Lin , Dong Li-Hua 
Published: May 2021

Abstract
Objective: Crotonylation of histones is a recently discovered type of post-translational modification that can regulate gene expression. However, the function of crotonylation on nonhistone proteins in vascular smooth muscle cells (VSMC) is unclear. In this study, we aim to use modification and proteomic analysis to find the cellular characteristic of crotonylated nonhistone proteins for deep research.Methods: In this article, we performed modification and proteomic analysis of VSMCs before and after platelet-derived growth factor-BB (PDGF-BB) stimulation. The crotonylated pan-antibody was used to enrich the protein and then subjected to high-throughput mass spectrometry analysis. Results: As a result, there were 2138 crotonylation sites in 534 proteins. These proteins are widely distributed in the cytoplasm, nucleus, and mitochondria, and participate in the cell metabolism processes such as amino acid synthesis, glycolysis, and glycogen synthesis. Conclusions: In summary, our bioinformatics shows that nonhistone crotonylation plays an important role in the VSMC phenotypic transformation induced by PDGF-BB stimulation.
Idiopathic Megacolon in an Adolescent Girl: a Case Report on a Rare Disease
Authors: Bahrudin Sharhanin , Moahamd Abdul Malek , Nor Azmi Mohd , Elagili Faisal 
Published: May 2021

Abstract
Introduction: Idiopathic Megacolon is a rare condition where there is persistent dilatation of colon in the absence of identifiable cause. Symptoms start as early as in childhood or in adulthood. Colectomy have shown to have high success rate in patient with idiopathic megacolon. We reported a case of an adolescent girl with idiopathic megacolon that was successfully treated with colectomy.Presentation of case: A 15 years old girl presented with a complaint of abdominal pain associated with gradual abdominal distension for 1 week duration, not passing flatus and had multiple episodes of vomiting. She was diagnosed to have sigmoid volvulus and underwent endoscopy decompression, however symptoms recurred. Segmental colectomy was performed and she had an uneventful recovery. Discussion: Patient presented with acute intestinal obstruction attributed to sigmoid volvulus with a history of constipation. A diagnostic dilemma between Hirschsprung’s disease with other causes of megacolon occurred as these diseases have similar presenting symptoms. A confirm histopathology of presence of ganglionic cells within the plexus exclude the diagnosis of Hirschsprung’s disease hence the diagnosis of Idiopathic Megacolon was made. Segmental colectomy give good result in relieving patient symptoms of abdominal pain and constipation and one of the recommended surgical options in treating Idiopathic Megacolon.Conclusion: Idiopathic megacolon is a rare disease and for a long time has been a disease of exclusion. Rectal biopsy is important to exclude the diagnosis of Hirschsprung’s Disease. There are wide variety of surgical treatment available in treating Idiopathic megacolon. Segmental Colectomy have shown good success rate.
Using Geographically Weighted Poisson Regression to Examine the Association Between Socioeconomic Factors and Hysterectomy Incidence in Wallonia, Belgium
Authors: Poliart Aline Clara , Kirakoya-Samadoulougou Fati , Ouédraogo Mady , Collart Philippe , Dubourg Dominique , Samadoulougou Sékou 
Published: May 2021

Abstract
Background: Various studies have investigated geographical variations in the incidence of hysterectomy in Western countries and analyzed socioeconomic factors to explain those variations. However, few studies have used spatial analysis to characterize them. Geographically weighted Poisson regression (GWPR) explores the spatially varying impacts of covariates across a study area and focuses attention on local variations. Given the potential of GWPR to guide decision-making, this study aimed to describe the geographical distribution of hysterectomy incidence for benign indications in women older than 15 years old (15+) at the municipal level in Wallonia (southern region of Belgium) and to analyze potential associations with socioeconomic factors (‘Education/training’, ‘Income and purchasing power’ and ‘Health and care’) influencing the use of this surgery.Methods: We carried out an ecological study on data for women aged 15 + living in one of the 262 Walloon municipalities who underwent hysterectomies for benign indications between 2012 and 2014. We linked standardized hysterectomy rates to three municipal-level socioeconomic factors (‘Education/training’, ‘Income and purchasing power’ and ‘Health and care’). Then, a generalized linear model (GLM) for Poisson regression and a GWPR were applied to study the relationships between hysterectomy incidence and socioeconomic covariates in Wallonia.Results: The hysterectomy rate varied across the region. The GLM Poisson regression revealed a positive and significant association between the hysterectomy rate and ‘Income and purchasing power’, and a negative and significant association between hysterectomies and ‘Health and care’. The same associations were seen in the GWPR model. The latter demonstrated that the association between hysterectomies and ‘Education and training’ ranged from negative to positive over the study area.Conclusions: Hysterectomy incidence was shown to have nonstationary relationships with socioeconomic factors. These results support the development of targeted interventions for a more appropriate use of this surgery.
Factors Associated with Mammographic Breast Density among Premenopausal and Menopausal Women in Karachi Pakistan
Authors: Shamsi Uzma , Afzal Shaista , Shamsi Azra , Azam Iqbal , Callen David 
Published: May 2021

Abstract
Background: There are no studies done to evaluate the distribution of mammographic breast density and factors associated with it among Pakistani women. Methods: Participants included 477 women, who had received either diagnostic or screening mammography at two hospitals in Karachi Pakistan. Mammographic breast density was assessed using the Breast Imaging Reporting and Data System. In person interviews were conducted using a detailed questionnaire, to assess risk factors of interest, and venous blood was collected to measure serum vitamin D level at the end of the interview. To determine the association of potential factors with mammographic breast density, multivariable polytomous logistic regression was used. Results: High-density mammographic breast density (heterogeneously and dense categories) was found in 62.4 % of women. There was a significant association of both heterogeneously dense and dense breasts with women of a younger age group < 45 years (OR= 2.68, 95% CI= 1.60-4.49) and (OR= 4.83, 95% CI= 2.54-9.16) respectively. Women with heterogeneously dense and dense breasts vs. fatty and fibroglandular breasts had a higher history of benign breast disease (OR = 1.90, 95% CI= 1.14–3.17) and (OR= 3.61, 95%CI= 1.90-6.86) respectively. There was an inverse relationship between breast density and body mass index. Women with dense breasts and heterogeneously dense breasts had lower body mass index (OR= 0.94 95% CI= 0.90-0.99) & (OR= 0.81, 95%CI= 0.76-0.87) respectively. There was no association of mammographic breast density with serum vitamin D levels, diet, and breast cancer. Conclusion: The findings of a positive association of higher mammographic density with younger age and benign breast disease and a negative association between body mass index and breast density are important findings that need to be considered in developing screening guidelines for the Pakistani population.
Biodeterioration of Microplastics: A promising step towards Plastics Waste Management
Authors: Tareen Aatikah , Iqbal Atia , Jamil Nazia 
Published: May 2021

Abstract

Polyethylene and Polyester materials are resistant to degradation and found as significant source of microplastics pollution, which is emerging concern. In the present study, potential of dumped site bacterial community was evaluated. After primary screening it was observed that 68.5% were linear low-density polyethylene, 33.3% were high-density and 12.9% were Polyester degraders. Up to five strains were chosen for secondary screening, where they were monitored by FTIR, SEM and weight loss degradation trials. Major results were observed by Alcaligenes faecalis (MK517568) and Bacillus cereus (MK517567), as they show highest degradation activity among others. Alcaligenes faecalis (MK517568) degrade LLDPE by 3.5%, HDPE by 5.8% and Polyester by 17.3%. Bacillus cereus (MK517567) better tolerated at 30oC and degrade Polyester by 29%. Changes in infrared spectra indicated degradation pathways of different strains with types of plastics targeted. Through SEM analysis, groves, piths and holes were observed on surface. These findings suggest that soil bacteria develop effective mechanism for degradation of microplastics and beads that enables them to utilize plastics as source of energy without need of pre-treatments, which highlights importance of these soil bacteria for fate of effective plastic waste management in soil environment.
WITHDRAWN: Experimental Study on the Law of Energy Dissipation and Damage in Coal Body Based on Local Tensile-Sliding Effect
Authors: Lv Xiangfeng , Li Xinyue , Pan Yishan 
Published: May 2021

Abstract
The slippage initiation and induced instability of roadway surrounding rock are highly likely to cause dynamic disasters, severely influencing the safety production of mining. With the optical-mechanical monitoring test of the deformation localization of energy dissipation, this study established the optical index of coal deformation equilibrium degree under load, and obtained the evolution law of coal deformation equilibrium degree. After analyzing the relationship between tensile-sliding effect and mechanical behavior of coal deformation field, it proposed the strain energy ratio coefficient. The results indicate that the strength reduction of coal body is affected by the deformation accumulation of loading displacement field. The sliding displacement of the stable sliding type specimen occurs 5.5s earlier than tensile displacement，which is 4.4s longer than the instantaneous instability type specimen. The instability type of coal is closely related to the tangent angle of the strain energy ratio coefficient and the damage persistence characteristics. The damage accumulation of stable equal amplitude contributes to the stable failure, and the damage accumulation of interval equal amplitude influences the instantaneous instability development. The fracture expansion stage is the main stage of energy consumption damage accumulation. That is, the main energy consumption damage accumulation stage of the stable slip coal is the stable crack expansion stage, with the damage proportion of 35.89%, while the damage proportion of instantaneous instability coal in the unsteady crack expansion stage is 84.226%. The study provides theoretical reference for the fracture law and risk monitoring of coal slippage.
Successful pregnancy in an ovarian Sertoli-Leydig cell tumor patient with heterologous elements: case report and literature review
Authors: Han Yali , Hao Shaohua , Guo Fengyi , Geng Lili , Li Jie , Du Xue 
Published: May 2021

Abstract
Background: Ovarian Sertoli-Leydig cell tumor (SLCT) is an extremely rare sex–cord stromal tumor of the ovary. Notably, ovarian SLCT with mucinous epithelium and liposarcoma is even rarer.There is also evidence that the presence of heterologous elements is a poor prognostic factor of SLCTs. Very often, ovarian SLCT patient first presents with high androgen levels and sometimes a clarge mass in the pelvic cavity, making it difficult for early diagnosis. Case presentation: In this study, we reported a SLCT patient with heterologous elements and elevated the serum alpha-fetoprotein (AFP) levels. A 22-year old nulliparous female was first admitted with clinical symptoms of abdominal pain, a large mass in the pelvic cavity and elevated serum AFP levels, and for this she underwent left adnexectomy. Pathological examination revealed ovarian SLCT with intestinal type mucinous epithelium and liposarcoma, and immunohistochemical staining revealed positive staining for AFP in the intestinal type mucinous epithelium. The patient became pregnant naturally four years later, but SLCT was found in the opposite ovary with liposarcoma but no significant increase in serum AFP levels.Further, we reviewed the literature in order to improve preoperative diagnosis and evaluation of long-term prognosis of SLCTs with heterologous elements.Conclusion: The increase in serum AFP levels could be used for preoperative diagnosis of the presence of heterologous elements and the postoperative recurrence.
Effects of sleep habits on acute myocardial infarction risk and severity of coronary artery disease in Chinese population
Authors: Lian Xiaoqing , Gu Jie , Wang Sibo , Yan Jianjun , Chen Xiaowen , Wang Mingwei , Zhang Yuqing , Wang Liansheng 
Published: May 2021

Abstract
Background

Growing evidence indicates that poor sleep harms health. Early to bed and early to rise is considered as a healthy lifestyle in Chinese population. The current study aimed to examine the effects of sleep habits on acute myocardial infarction (AMI) risk and severity of coronary artery disease (CAD) in Chinese population from two centers.
Methods

A total of 873 patients including 314 AMI and 559 controls were recruited from the inpatient cardiology department of the Affiliated Jiangning Hospital and the First Affiliated Hospital of Nanjing Medical University. 559 controls included 395 CAD cases and 164 non-CAD cases. We used a 17-item sleep factors questionnaire (SFQ) to evaluate sleep habits comprehensively by face-to-face interview. The severity of CAD was assessed by Gensini score in AMI and CAD groups. The effects of sleep factors on AMI risk and Gensini score were examined by unconditional logistic regression.
Results

After mutually adjustment for other sleep factors and demographic characteristics, the timing of sleep (24:00 and after), sleep duration (< 6h) and frequency of night-time waking (3 times) were associated with increased risk of AMI. In subjects with age < 65 years, sleep duration (< 6h) was correlated with increased risk of AMI (OR 3.096, 95%CI 1.435–6.681, P = 0.004) and daytime napping was related to reduced risk of AMI (OR 0.620, 95%CI 0.397–0.970,P = 0.036). In the population aged ≥ 65 years, the level 3 of light exposure (they could see only the hazy outline of the bedroom) was correlated with lowered risk of AMI. Late sleep timing (24:00 and after) and the frequency of night-time waking (3 times) were associated with increased risk of AMI independently of age. Moreover, Short sleep duration was correlated with increased risk of high Gensini score.
Conclusion

Late sleeping is an important risk factor for AMI. Daytime napping may protect the population aged < 65 years.
Factor Affecting COVID-19 Vaccine Hesitancy in Bangladesh: An Empirical Investigation
Authors: Arefin Kazi Asequl , Hossain Anwar , Rahman Md. H Asibur 
Published: May 2021

Abstract
This study aims to look at the causes of COVID-19 vaccine hesitancy in Bangladesh by examining the cultural and religious values, lack of trust, misinformation, and fear of side effects as predictors of vaccine hesitancy. Self-developed measurement items, developed based on the expert's opinion, were used to accomplish the objective. Data was gathered from 268 respondents who represented their community through both an online and a physical survey. SPSS version 25 was used to optimize descriptive statistics. Besides, SmartPLS 3.0 was used to examine the hypotheses using the PLS-SEM approach. The study confirms that lack of trust, misinformation and fear of side effects all play a role in vaccine hesitancy. Besides, the results have many significant implications for public health policymakers, vaccine manufacturers and distributors, and the media. Besides that, the study proposes some new research avenues for overcoming this study's limitations and gaining more detailed information on the topic.
PAciFy Cough – A multicentre, double blind, placebo controlled, crossover trial of morphine sulfate for the treatment of PulmonAry Fibrosis Cough
Authors: Wu Zhe , Banya Winston , Chaudhuri Nazia , Jakupovic Ira , Maher Toby , Patel Brijesh , Spencer Lisa , Thillai Muhunthan , West Alex , Westoby John , Wijsenbeek Marlies , Smith Jaclyn , Molyneaux Philip 
Published: May 2021

Abstract
Background: Idiopathic pulmonary fibrosis (IPF) is a progressive disease that leads to lung scarring, Cough is reported by 85% of patients with IPF and can be a distressing symptom with a significant impact on patients’ quality of life. There are no proven effective therapies for IPF related cough. While morphine is frequently used as a palliative agent for breathlessness in IPF, its effects on cough have never been tested. PAciFy Cough is a multicenter, double-blind, placebo-controlled, crossover trial of morphine sulfate for the treatment of cough in IPF. Methods: We will recruit 44 subjects with IPF prospectively from three interstitial lung disease units in the UK, namely the Royal Brompton Hospital, Manchester University NHS Foundation Trust (MFT) and Aintree University Hospital NHS Foundation Trust. Patients will be randomized (1:1) to either placebo twice daily or morphine sulfate 5mg twice daily for 14 days. They will then crossover after a 7 day washout period. The primary endpoint is the percent change in daytime cough frequency (coughs per hour) from baseline as assessed by objective cough monitoring at Day 14 of treatment.Discussion: This multicentre, randomised trial will assess the effect of opioids on cough counts and cough associated quality of life in IPF subjects. If proven to be an effective intervention, it represents a readily available treatment for patients.Trial registration: The study was approved by the UK Medicines and Healthcare Regulatory Agency (Ref: CTA 21268/0224/001-0001 – EUDRACT 2019-003571-19 – Protocol Number RBH2019/001) on 08 April 2020, in compliance with the European Clinical Trials Directive and the Medicines for Human Use (Clinical Trials) Regulations 2004 and its subsequent amendments. The study was provided with ethical approval by the London Brent Research Ethics Committee (Ref: 20/LO/0368) on 21 May 2020 and is registered with clinicaltrials.gov (NCT04429516) on 12 June 2020, available at https://clinicaltrials.gov/ct2/show/NCT04429516
Tractography of the Arcuate Fasciculus in Healthy Right-Handed and Left-Handed Multilingual Subjects and Its Relation to Language Lateralization on Functional MRI
Authors: Yazbek Sandrine , Hage Stephanie , Mallak Iyad , Smayra Tarek 
Published: May 2021

Abstract
Purpose Functional MRI (fMRI) enables evaluation of language cortical organization and plays a central role in surgical planning. Diffusion Tensor Imaging (DTI) or Tractography, allows evaluation of the white matter fibers involved in language. Unlike fMRI, DTI does not rely on the patient's cooperation. In monolinguals, there is a good correlation between the lateralization of language on fMRI and on DTI. Our objective is to delineate the arcuate fasciculus (AF) in right- and left-handed trilinguals and determine if the AF laterality on DTI is correlated to language lateralization on fMRI.Methods 15 right and 15 left-handed trilingual volunteers underwent fMRI and DTI. Laterality Index was determined on fMRI (fMRI-LI). Mean Diffusivity, Fractional Anisotropy (FA), Number of Fibers, Fiber Length, Fiber Volume and Laterality Index (DTI-LI) of the AF were calculated on DTI.Results 28 of the 30 subjects presented a bilateral AF. Most subjects (52%) were found to have a bilateral language lateralization of the AF on DTI. Only 4 subjects had bilateral lateralization of language on fMRI. The right AF demonstrated lower diffusivity than the left AF in the total participants, the right-handed, and the left-handed subjects. FA, Volume and Length of the AF were not significantly different between the two hemispheres. No correlation was found between the DTI-LI of the AF and the fMRI-LI.Conclusion A prominent role of the right AF and a bilateral structural organization of the AF was present in our multilingual population regardless of their handedness. While in prior studies DTI was able to determine language lateralization in monolingual subjects, this was not possible in trilingual highly educated subjects.