bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individual and community-level factors associated with modern contraceptive use among adolescent girls and young women in Ethiopia: a multilevel analysis of 2016 Ethiopia demographic and health survey
Authors: Hailegebreal Samuel , Seboka Binyam Tariku , Ahmed Mohammedjud Hassen , Teferi Gizaw Hailiye , Regasa Zegaye , Tekabe Beemnet , Sako Sewunet , Gilano Girma 
Published: November 2021

Abstract
Background
The importance of contraception use is immense for young girls of age 15–24 years. In literatures, there were significant attempts made to study factors associated with adolescent and young women contraception use in Africa. Despite the resulting interventions followed those studies, the contraception uses among youth population in Africa remained below average. Thus, this study is aimed to assess individual and community-level factors associated with contraceptive use in Ethiopian context to support further interventions.

Methods
Our analysis was based on the secondary data from Ethiopia Demography and Health Survey (EDHS) 2016. Adolescent girls and young women (AGYW) aged 15–24 years were the target population. Means, standard deviations, and proportions were used to describe the study population. To control for the variations due to the differences between clusters, a series of multilevel logistic regression modeling steps were followed and determinants of contraceptive use were outplayed. All variables with bivariate p-value < 0.25 were included in the models and p-value < 0.05 was used to declare associations.

Results
The prevalence of modern contraceptive use among AGYW in Ethiopia was 34.89% [95% CI, 0.32, 0.36]. Married adolescents were 2.01 times [AOR = 2.01, 95% CI = 1.39,3.16], having work was 1.36 times [AOR = 1.36, 95% CI = 1.06,1.71], living in urban areas was 1.61 times [AOR = 1.61, 95% CI = 1.16,2.45], being in middle wealth status was 1.9 times [AOR = 1.90, 95% CI = 1.32,2.65], being in rich wealth quintile was 1.99 time [AOR = 1.99, 95% CI = 1.35,2.68], and having TV exposure was 1.61 times [AOR = 1.6, 95% CI = 1.17,2.20] more likely associated with modern contraceptive uses.

Conclusion
The use of modern contraception among AGYW in the country remained appealing and factors like region, residence, marital status, wealth index, religion, working status, parity, husband desire children, ever aborted AGYW, and the television exposures were attributed for the poor improvements. Therefore, the enhancements that consult those factors remained remarkable in improving contraception use, while further increasing in educational engagement, access to health services, and economic empowerment of the AGYW might be the good advantages for the improvements.
Feasibility of a randomized hypertension screening initiative in the perioperative setting
Authors: Diaz Sofia I. , Yan Luying , Dai Feng , Zhou Bin , Burg Matthew M. , Schonberger Robert B. 
Published: November 2021

Abstract
Objectives
This study sought to assess feasibility of a randomized trial of blood pressure intervention (home blood pressure monitoring vs. counseling) in the preoperative clinic and the baseline rates of primary care follow-up after such interventions.

Methods
A prospective randomized feasibility study was performed at Yale New Haven Hospital Preadmission Testing Clinic. A sample of 100 adults, with elevated blood pressure, were recruited during their preadmission visit, and randomized 1:1 to receive brief BP counseling and an educational brochure versus additionally receiving a home BP monitor (HBPM) with a mailed report of their home readings. At 60-day post-surgery telephone follow-up, investigators asked whether participants had primary-care follow-up; had new/adjusted hypertension treatment; and felt satisfied with the study.

Results
There were 51 patients in the counseling group and 49 in the HBPM group. Of 46 patients in the HBPM group who returned their monitors, 36 (78%) were hypertensive at home. At 60 days post-surgery, 31 (61%) patients in the counseling group and 30 (61%) in the HBPM group were reached by telephone with the remaining followed by EHR. Thirty-six (71%) patients in the counseling group and 36 (73%) in the HBPM group had seen their primary care provider. Seventeen of 36 (47%) in the counseling group and 18 of 31 (58%) in the HBPM group received new or adjusted hypertension medications. Sixty-one participants answered questions regarding their satisfaction with the study with 52 (85%) reporting that they felt moderately to very satisfied.

Conclusions
This feasibility study suggests that interventional blood pressure trials in the preoperative clinic are feasible, but telephone follow-up leads to significant gaps in outcome ascertainment.

Trial registration
Clinicaltrials.gov, NCT03634813. Registered 16 of August 2018.
RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulation
Authors: Yuan Qi , Dridi Haikel , Clarke Oliver B. , Reiken Steven , Melville Zephan , Wronska Anetta , Kushnir Alexander , Zalk Ran , Sittenfeld Leah , Marks Andrew R. 
Published: November 2021

AbstractThe type 1 ryanodine receptor (RyR1) is an intracellular calcium (Ca2+) release channel on the sarcoplasmic/endoplasmic reticulum that is required for skeletal muscle contraction. RyR1 channel activity is modulated by ligands, including the activators Ca2+ and ATP. Patients with inherited mutations in RyR1 may exhibit muscle weakness as part of a heterogeneous, complex disorder known as RYR1-related myopathy (RYR1-RM) or more recently termed RYR1-related disorders (RYR1-RD). Guided by high-resolution structures of skeletal muscle RyR1, obtained using cryogenic electron microscopy, we introduced mutations into putative Ca2+ and ATP binding sites and studied the function of the resulting mutant channels. These mutations confirmed the functional significance of the Ca2+ and ATP binding sites identified by structural studies based on the effects on channel regulation. Under normal conditions, Ca2+ activates RyR1 at low concentrations (µM) and inhibits it at high concentrations (mM). Mutations in the Ca2+-binding site impaired both activating and inhibitory regulation of the channel, suggesting a single site for both high and low affinity Ca2+-dependent regulation of RyR1 function. Mutation of residues that interact with the adenine ring of ATP abrogated ATP binding to the channel, whereas mutating residues that interact with the triphosphate tail only affected the degree of activation. In addition, patients with mutations at the Ca2+ or ATP binding sites suffer from muscle weakness, therefore impaired RyR1 channel regulation by either Ca2+ or ATP may contribute to the pathophysiology of RYR1-RM in some patients.
Impact of primary dentition malocclusion on the oral health-related quality of life in preschoolers
Authors: de Vasconcelos Fernanda Marques Torres , Vitali Filipe Colombo , Ximenes Marcos , Dias Loraine Fernandes , da Silva Carla Pereira , Borgatto Adriano Ferrati , Bolan Michele , Cardoso Mariane 
Published: November 2021

Abstract
Background
Malocclusion is a condition frequently seen in primary dentition due to the interaction of environmental, genetic and behavioural factors. The occurrence of some types of malocclusions can have an impact on oral health-related quality of life in children. Hence, the present study aimed to verify the impact of primary dentition malocclusion on oral health-related quality of life in preschool children.

Methods
A population-based cross-sectional study was conducted in Florianopolis, Brazil, with a representative sample of 1050 preschoolers aged between 2 and 5 years, randomly selected. Parents answered the Brazilian version of the Early Childhood Oral Health Impact Scale and also to a questionnaire on socio-economic indicators. Data obtained from the questionnaire were obtained by item response theory based on model of gradual response. The malocclusion assessed was: anterior open bite, increased overjet and posterior crossbite. Poisson regression model was employed for multivariate analysis (P < 0.05).

Results
Malocclusion was observed in 36.7% of the children. Of these, 11.4% were anterior open bite, 67.2% were increased overjet, and 21.4% were posterior crossbite. Malocclusion's impact on oral health-related quality of life was 28.6%. In children aged 4–5 years, the prevalence of malocclusion’s impact on quality of life was 49.5% higher than in children aged 2–3 years. Statistical analysis showed that preschool children with malocclusion showed no significant impact on quality of life.

Conclusions
The findings of the present study indicate that the occurrence of primary dentition malocclusion has no impact on the quality of life of children aged 2–5 years.
Appendix-preserving elective herniorrhaphy for de Garengeot hernia: two case reports
Authors: Imataki Hiromitsu , Miyake Hideo , Nagai Hidemasa , Yoshioka Yuichiro , Shibata Koji , Kambara Yuichi , Yuasa Norihiro 
Published: November 2021

Abstract
Background
Emergency appendectomy is often performed for de Garengeot hernia. However, in some cases, there may be a chance to perform an appendix-preserving elective surgery.

Case description
A 76-year-old woman presented to our hospital with complaints of a right inguinal swelling, which we diagnosed as a de Garengeot hernia using computed tomography (CT). B-mode ultrasonography (US) of the mass showed an appendix 4–6 mm in diameter with a clear wall structure; color Doppler US showed pulsatile blood flow signal in the appendiceal wall. Twenty-eight days later, herniorrhaphy with transabdominal preperitoneal repair (TAPP) was performed without appendectomy. Another 70-year-old woman presented to our hospital with complaints of a painful bulge in the right inguinal region. The diagnosis of de Garengeot hernia was made using CT. B-mode US showed an appendix 5 mm in diameter with a clear wall structure. Color Doppler US showed a pulsatile blood signal in the appendiceal wall. Seven days later, herniorrhaphy with TAPP was performed without appendectomy.

Conclusion
De Garengeot hernia is often associated with appendicitis; however, an appendix-preserving elective herniorrhaphy can be performed if US and intraoperative findings do not suggest appendicitis or circulatory compromise in the appendix.
Use of hydrocolloid dressing in infants requiring open chest management after cardiac surgery
Authors: Yokoyama Shinya , Tonomura Rei , Fukuba Ryohei , Mitani Kazuhiro , Uemura Hideki 
Published: November 2021

Abstract
Purpose
Sternal splintage is known as an effective maneuver to stabilize hemodynamics during the immediate postoperative period, particularly in very sick infants. On the other hand, its wound management is not always straightforward. We employed dressing using a product made of a hydrocolloid material in such circumstances. This report describes our experience in utilizing the dressing in term of its potential advantages.

Materials and methods
Six infants needed open chest management following complicated procedures for congenital heart disease. A polytetrafluoroethylene patch was fixed to augment the skin defect at the time of sternal splintage, and a hydrocolloid dressing was applied to entirely cover the wound including the suture line.

Result
All patients survived their difficult circumstances. None of them suffered wound complications such as infection or healing problem during sternal splintage or subsequent to eventual chest closure. The dressing product was easy to handle with no adverse events associated with its material.

Conclusions
It is reconfirmed that a dressing made of hydrocolloid material was of practical use for sealing the wound in infants requiring open chest management after cardiac surgery.
Evaluation of the Functional Movement Screen (FMS) in Identifying Active Females Who are Prone to Injury. A Systematic Review
Authors: Asgari Mojtaba , Alizadeh Shahab , Sendt Anna , Jaitner Thomas 
Published: November 2021

Abstract
Background
The validity of the Functional Movement Screen (FMS) in identifying active females who are predisposed to injury has not been specifically reviewed. This study aims to synthesize the literature on the ability of the FMS to identify at-risk active females.

Methods
Six online databases, including PubMed, Medline, Web of Science, Science Direct, SPORTDiscus and Google Scholar, were searched for the period of April 2006 to September 2021. Out of the 61 potential references, 17 were reviewed in detail with respect to the inclusion criteria; ten were ultimately included. The risk of bias, applicability and level of the studies were then identified using the QUADAS-2 and a checklist for assessing methodological quality. The following data were obtained from the included studies: year of publication, title, study type, participants’ demographic, sample size, FMS cutoff point, injury definition, statistical analyses used, FMS results and study level.

Results
Generally, the quality of eight studies was poor to moderate due to both small sample sizes and short follow-up periods. Except for a study on military members, all studies were carried out on team sports players. The overall bias of the studies was low, but there was an unclear amount of bias for participant selection. Two studies reported no predictive validity for the FMS, while three defended its predictive validity; the rest partially supported the FMS as a valid diagnostic tool. The reliability of the recommended cutoff point was confirmed, though cutoffs higher than 14 were significantly associated with the predictive ability of the FMS.

Conclusion
Although the FMS is reliable for clinical practice, and the current literature shows promise regarding the predictive ability of the FMS among active females, concerns remain regarding its validity in identifying at-risk females. Given the lack of clarity in the literature on the use of the FMS in females, further well-organized studies with larger sample sizes and longer monitoring periods are highly recommended. The sensitivity and specificity of the recommended cutoff of ≤ 14 has considerably decreased , and higher cutoff values should be applied to increase the FMS predictive ability.
Level of evidence The level of evidence was determined to be 2b.
Lossy mode resonances in photonic crystal fibers
Authors: Sicacha Mauricio Salazar , Minkovich Vladimir P. , Sotsky Alexander B. , Shilov Artur V. , Sotskaya Luidmila I. , Chudakov Evgeny A. 
Published: November 2021

AbstractThe interaction effect of the fundamental mode in a special photonic crystal fiber (PCF) with a thin-film absorbing coating deposited on a surface of a fiber cladding on the optical transmission of the PCF is theoretically studied. It is shown that the transmission has a multi-peak spectrum that is determined by the resonance capture of the fundamental PCF mode energy by the coating. In some cases, this capture is explained by a resonance coupling between the fundamental core mode and leaky modes of the coating, or between the fundamental PCF mode and cladding modes located between PCF air channels and the coating. Examples are presented of using this effect to develop fiber-optic sensors of refractive index or pressure, and to sense a nanoscale adsorption layer of ammonia molecules deposited on a coating surface contacting air.
Inflammatory response in the mid colon of ICR mice treated with polystyrene microplastics for two weeks
Authors: Choi Yun Ju , Kim Ji Eun , Lee Su Jin , Gong Jeong Eun , Jin You Jeong , Seo Sungbaek , Lee Jae Ho , Hwang Dae Youn 
Published: November 2021

AbstractBackgroundThe oral administration of polystyrene-microplastics (PS-MPs) causes chronic constipation of ICR mice, but there are no reports on their effects on the inflammatory response in the colon. To determine if the oral administration of MPs causes inflammation in the colon, the changes in the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC)-inflammasome pathway, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway, and inflammatory cytokine expression were evaluated in the mid colon of ICR mice treated with 0.5 μm size PS-MPs for two weeks.ResultsThe thicknesses of the mucosa, muscle, flat luminal surface, and crypt layer were decreased significantly (p < 0.01) in the mid colon of the MPs treated group compared to the Vehicle treated group. On the other hand, a remarkable increase in the expression levels of NOD-like receptor pyrin domain-containing protein (NLRP) 3, ASC, and Cleaved Caspase (Cas)-1 protein was observed in the MPs treated group. In addition, similar increasing pattern in the levels of p-NF-κB and phospho-inhibitory subunit of NF-κB (p-IkB) α protein was detected. Four inflammatory cytokines, including NF-κB, interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1β, showed an increased expression level after the MPs treatment.ConclusionsTherefore, the present study suggests that PS-MPs can be a novel cause of an inflammatory response in the mid colon of ICR mice.
The Advent of Media Modernity out of Wild Bill's Ashes
Authors: Adleman Daniel 
Published: November 2021

AbstractThis article positions David Milch's Deadwood (2004–6) as a narrative universe that merits serious theoretical scrutiny on account of its far-reaching account of the dawn of American technocapitalism. While Kittlerian media-archaeological wisdom situates media modernity's primal scene at the turn of the century (with the emergence of the Edisonian gramophone, film, and typewriter), Deadwood figures the multimedia Big Bang as having taken place a few decades prior, with the advent of telegraphy, photography, and railroads. In the world of Deadwood, this “Discourse Network 1876” condenses in the spectral figure of George Hearst, a tyrannical mining and media magnate who descends on Deadwood to seize and consolidate the area's gold mining rights. When community leaders Al Swearengen and Seth Bullock rise up to resist Hearst, he wields the cybernetic grid of Discourse Network 1876 to run roughshod over the town's fragile social compact. Although this vision of the American Leviathan is a bleak one (and therein resides much of Deadwood's tragic mythos), Milch's Deadwood: The Movie (2019) revisits the town a decade later and rehabilitates the notion that a tightknit community of concerned citizens can, under the right conditions, serve as a viable, but precarious, bulwark against the Hearstian electrical storm.
The Scouring of Wellywood
Authors: Williams Ian 
Published: November 2021

Abstract
This article uses the work of brand theorists and New Zealand–based cultural critics to examine the circumstances that created the “Hobbit Law,” a New Zealand law aimed at busting local film industry unions. Branding logics created a struggle for authenticity around the importance of Middle-earth to New Zealand's national identity in the twenty-first century. This hybrid identity was then articulated as something that stood against labor actions by film industry workers, culminating in citizen marches against local labor. It closes by exploring ways that the importance of the brand as sense-making tool under neoliberalism might be reconfigured as something that might bridge the gap between media consumer and creative industry worker.
Decaffeinated coffee and green tea extract inhibit foam cell atherosclerosis by lowering inflammation and improving cholesterol influx/efflux balance through upregulation of PPARγ and miR-155
Authors: Rachmawati Ermin , Rohman Mohammad Saifur , Sargowo Djanggan , Kalsum Umi , Lyrawati Diana , Lukitasari Mifetika 
Published: November 2021

Background:Foam cells are markers of atherosclerosis and characterise advanced atherosclerotic plaque, stimulated by inflammation caused by high lipid levels in macrophages. The combination of decaffeinated coffee and green tea extract (DCGTE) has been suggested to have a role in foam cell inhibition.Objective: we investigated the inhibiting role of DCGTE against foam cell formation, through modulation of the inflammation process and cholesterol metabolism in macrophage colony stimulating factor- (M-CSF) and oxidized low-density lipoprotein (oxLDL)-exposed macrophages.Methods: Coffee and green tea were extracted by filtration and infusion respectively, and underwent decaffeination using active carbon and blanching methods, respectively. Cells were administered 160/160 and 320/320μg/ml of DCGTE. Foam cell formation was observed using a light microscope after staining with Oil Red O (ORO), and the accumulation of lipids in macrophages with ELISA. Observations of lipid influx and efflux were determined through semiquantitative cluster differentiation 36 (CD36) and ATP binding cassette transporter A1 (ABCA1) expression through immunofluorescence. The inflammation process was quantified using inflammatory/anti-inflammatory markers, e.g., tumor necrosis factor α (TNFα) and interleukin 10 (IL10) with ELISA. Peroxisome proliferator activated response γ (PPARγ) expression and activity were assessed with PCR and ELISA, respectively. The expression of microRNA 155 (miR-155) was examined using qPCR.Results:DCGTE at the above concentrations tended to reduce foam cell numbers, significantly inhibited lipid accumulation (p=0.000), reduced CD36 expression (p=0.000) and TNFα secretion (p=0.000) in Raw264.7 exposed to M-CSF 50ng/ml and oxLDL 50μg/ml. PPARγ expression (p=0.00) and activity (p=0.001), miR-155 relative expression (p=0.000), and IL10 production (p=0.000) also increased.Conclusion:DCGTE lowered foam cell numbers, possibly through attenuation of the inflammatory process and improvement of lipid/efflux mechanisms in M-CSF and oxLDL-stimulated Raw264.7 cells, via upregulation of PPARγ and miR-155. Our results suggest DCGTE may help prevent atherosclerosis-based diseases.
Dynamics of changes in the ultrastructural characteristics of the mucosa and cartilage of the larynx of rats at the end of 35 and 42 days of experimental opioid exposure and after 56 days with opioid withdrawal
Authors: Ivasivka K. , Paltov E. , Masna Z. , Chelpanova I. 
Published: November 2021

In our work, we studied the ultrastructural organization of rat laryngeal mucosa and cartilage at the end of 35 and 42 days of experimental opioid exposure and at the end of 56 days with opioid withdrawal. As a result of our study at the end of the 35th day at the ultrastructural level revealed hypersecretion of goblet cells, mucus contained impurities of lymphocytes, single neutrophils and erythrocytes. In the enlarged lumens of the hemocapillaries of the lamina propria of the mucous membrane and submucosal base of different parts of the larynx, the adhesion of erythrocytes was noted. At the end of 42 days in rats, the changes were characterized by moderate damage to cytoplasmic organelles in epitheliocytes. Alternative changes developed in the chondrocytes of elastic and hyaline cartilages. Marked by an increase in the number of active fibroblasts, next to which were numerous fibrils of collagen fibers. The main substance of connective tissue, near dilated vessels, was impregnated with transudate, which was accompanied by the development of perivasal edema. Glycogen grains and vacuoles filled with neutral fats were visualized in the cytoplasm of chondrocytes.At the end of 56 days in rats with two-week withdrawal of the opioid analgesic, we found the development of alternative processes in the epitheliocytes of different parts of the larynx, as well as in chondrocytes, especially in elastic cartilage. Dyscirculatory processes in vessels of own plate of a mucous membrane and a submucous basis of various departments of a larynx were registered. Necrotic changes developed in the columnar epitheliocytes of the submucosal mucosa. Mitochondria swelled, their matrix brightened, cristae collapsed.
The results of the article correspond to the research plan of Danylo Halytskyi Lviv National Medical University and are part of the research topic of the Department of Normal Anatomy "Morphofunctional features of organs in pre - and postnatal periods of ontogenesis, under the influence of opioids, food supplements, reconstructive surgery and obesity" 0120U002129) during 2020 - 2024.