bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inducible Sbds deletion impairs bone marrow niche capacity to engraft donor bone marrow after transplantation
Authors: Zha Ji , Kunselman Lori K. , Xie Hongbo M. , Ennis Brian , Shah Yash B. , Qin Xia , Fan Jian-Meng , Babushok Daria V. , Olson Timothy S. 
Published: October 2021

Abstract
Bone marrow (BM) niche-derived signals are critical for facilitating engraftment after hematopoietic stem cell (HSC) transplantation (HSCT). HSCT is required for restoration of hematopoiesis in patients with inherited BM failure syndromes (iBMFSs). Shwachman-Diamond syndrome (SDS) is a rare iBMFS associated with mutations in SBDS. Previous studies have demonstrated that SBDS deficiency in osteolineage niche cells causes BM dysfunction that promotes leukemia development. However, it is unknown whether BM niche defects caused by SBDS deficiency also impair efficient engraftment of healthy donor HSC after HSCT, a hypothesis that could explain morbidity noted after clinical HSCT for patients with SDS. Here, we report a mouse model with inducible Sbds deletion in hematopoietic and osteolineage cells. Primary and secondary BM transplantation (BMT) studies demonstrated that SBDS deficiency within BM niches caused poor donor hematopoietic recovery and specifically poor HSC engraftment after myeloablative BMT. We have also identified multiple molecular and cellular defects within niche populations that are driven by SBDS deficiency and are accentuated by or develop specifically after myeloablative conditioning. These abnormalities include altered frequencies of multiple niche cell subsets, including mesenchymal lineage cells, macrophages, and endothelial cells; disruption of growth factor signaling, chemokine pathway activation, and adhesion molecule expression; and p53 pathway activation and signals involved in cell cycle arrest. Taken together, this study demonstrates that SBDS deficiency profoundly impacts recipient hematopoietic niche function in the setting of HSCT, suggesting that novel therapeutic strategies targeting host niches could improve clinical HSCT outcomes for patients with SDS.
The role of emotional eating and BMI in the context of chocolate consumption and avoiding situations related to body exposure in women of normal weight
Authors: Modrzejewska Adriana , Czepczor-Bernat Kamila , Brytek-Matera Anna 
Published: October 2021

Cel pracyCelem badań było określenie roli jedzenia emocjonalnego oraz wskaźnika masy ciała (BMI) w relacji między pragnieniem konsumpcji czekolady a unikaniem sytuacji społecznych związanych z jedzeniem i ekspozycją ciała u kobiet z prawidłową masą ciała.Testowano efekt bezpośredni, pośredni i buforowy oraz model moderowanej mediacji.MetodaBadaniem objęto 311 kobiet. Średnia wieku wyniosła 25,56 lat (SD = 8,99), zaś wskaźnik BMI równy był 23,19 kg/m2 (SD = 5,05). W badaniu wykorzystano Three-Factor Eating Questionnaire, Kwestionariusz Postaw wobec Czekolady oraz Body Image Avoidance Questionnaire.WynikiUzyskane rezultaty pokazują, że pomiędzy jedzeniem emocjonalnym a wskaźnikiem BMI oraz unikaniem sytuacji społecznych związanych z jedzeniem i ekspozycją ciała istnieje słaby dodatni związek. Natomiast silny dodatni związek obserwuje się w odniesieniu do relacji pomiędzy jedzeniem emocjonalnym a pragnieniem spożycia czekolady. Jedzenie emocjonalne jest również istotnym całkowitym mediatorem związku między unikaniem sytuacji społecznych związanych z jedzeniem i ekspozycją ciała a pragnieniem spożycia czekolady. Natomiast, nie moderuje związku między tymi zmiennymi.WnioskiPrezentowane wyniki dowodzą, że jedzenie emocjonalne istotnie wiąże się z wskaźnikiem BMI, postawami wobec czekolady i własnego ciała u badanych kobiet z prawidłową masą ciała. Ważnym elementem jest również sam wskaźnik BMI, który wchodzi w interakcję ze stosunkiem wobec własnego ciała oraz jedzenia. Uzyskane wyniki badań dają podstawę, aby wnioskować, że jedzenie emocjonalne oraz wskaźnik masy ciała są znaczącymi elementami, na które należy zwrócić uwagę w zmianie nawyków żywieniowych oraz pracy nad akceptacją własnego ciała.
Heterogeneity of cognitive profiles in students with borderline intellectual functioning
Authors: Jankowska Anna , Łockiewicz Marta , Łada-Maśko Ariadna 
Published: October 2021

Cel pracyInteligencja niższa niż przeciętna (ang. Borderline Intellectual Functioning - BIF) jest jednostką kliniczną o polietiologicznym podłożu, którą cechuje różnorodność deficytów poznawczych. Celem badania było wyróżnienie i opisanie grup o homogenicznych profilach funkcjonowania poznawczego w heterogenicznej grupie uczniów z inteligencją niższą niż przeciętna.MetodaProfile poznawcze 114 uczniów z BIF zostały wyróżnione i scharakteryzowane na podstawie wyników uzyskanych przez badanych w Skali Inteligencji Wechslera dla Dzieci – Wersja Zmodyfikowana.WynikiPrzy użyciu hierarchicznej analizy skupień, wyróżniono cztery odmienne profile funkcjonowania poznawczego: a) dzieci z głębokimi deficytami umiejętności werbalnych, a zdolnościami wzrokowo-przestrzennymi na poziomie przeciętnym; b) dzieci z deficytami pamięci krótkotrwałej i uwagi; c) dzieci o profilu ACID, typowym dla trudności w uczeniu się; d) dzieci o ,,spłaszczonym’’ profilu funkcjonowania poznawczego, w którym wszystkie zdolności werbalne i niewerbalne były na poziomie niższym niż przeciętny.WnioskiMożliwość zidentyfikowania zarówno mocnych stron, jak i trudności w funkcjonowaniu poznawczym na podstawie odmiennych profili funkcjonowania poznawczego uczniów z BIF, ma istotne znaczenie dla prawidłowego rozpoznania tych uczniów oraz zróżnicowanego podejścia do opracowywania interwencji edukacyjnych i wspierających rozwój.
Impacts of mild COVID-19 on elevated use of primary and specialist health care services: A nationwide register study from Norway
Authors: Skyrud Katrine Damgaard , Hernæs Kjersti Helene , Telle Kjetil Elias , Magnusson Karin 
Published: October 2021

Aim
To explore the temporal impact of mild COVID-19 on need for primary and specialist health care services.

Methods
In all adults (≥20 years) tested for SARS-CoV-2 in Norway March 1st 2020 to February 1st 2021 (N = 1 401 922), we contrasted the monthly all-cause health care use before and up to 6 months after the test (% relative difference), for patients with a positive test for SARS-CoV-2 (non-hospitalization, i.e. mild COVID-19) and patients with a negative test (no COVID-19).

Results
We found a substantial short-term elevation in primary care use in all age groups, with men generally having a higher relative increase (men 20–44 years: 522%, 95%CI = 509–535, 45–69 years: 439%, 95%CI = 426–452, ≥70 years: 199%, 95%CI = 180–218) than women (20–44 years: 342, 95%CI = 334–350, 45–69 years = 375, 95%CI = 365–385, ≥70 years: 156%, 95%CI = 141–171) at 1 month following positive test. At 2 months, this sex difference was less pronounced, with a (20–44 years: 21%, 95%CI = 13–29, 45–69 years = 38%, 95%CI = 30–46, ≥70 years: 15%, 95%CI = 3–28) increase in primary care use for men, and a (20–44 years: 30%, 95%CI = 24–36, 45–69 years = 57%, 95%CI = 50–64, ≥70 years: 14%, 95%CI = 4–24) increase for women. At 3 months after test, only women aged 45–70 years still had an increased primary care use (14%, 95%CI = 7–20). The increase was due to respiratory- and general/unspecified conditions. We observed no long-term (4–6 months) elevation in primary care use, and no elevation in specialist care use.

Conclusion
Mild COVID-19 gives an elevated need for primary care that vanishes 2–3 months after positive test. Middle-aged women had the most prolonged increased primary care use.
Translation and validation of the Alberta Context Tool for use in Norwegian nursing homes
Authors: Igland Jannicke , Potrebny Thomas , Bendixen Bente E. , Haugstvedt Anne , Espehaug Birgitte , Titlestad Kristine B. , Graverholt Birgitte 
Published: October 2021

Purpose
Organizational context is recognized as important for facilitating evidence-based practice and improving patient outcomes. Organizational context is a complex construct to measure and appropriate instruments that can quantify and measure context are needed. The aim of this study was to translate and cross-culturally adapt the Alberta Context Tool (ACT) to Norwegian, and to test the reliability and structural validity among registered nurses (RNs) and licenced practice nurses (LPNs) working in nursing homes.

Methods
This study was a validation study utilizing a cross-sectional design. The sample consisted of n = 956 healthcare personnel from 28 nursing homes from a municipality in Norway. In the first stage, the ACT was translated before being administered in 28 nursing homes. In the second stage, internal consistency and structural validity were explored using Cronbach’s alpha and confirmatory factor analysis.

Results
A rigorous forward-and-back translation process was performed including a team of academics, experts, professional translators and the copyright holders, before an acceptable version of the ACT was piloted and finalized. The Norwegian version of the ACT showed good internal consistency with Chronbachs alpha above .75 for all concepts except for Formal interactions where the alpha was .69. Structural validity was acceptable for both RNs and LPNs with factors loadings more than .4 for most items.

Conclusions
The Norwegian version of the ACT is a valid measure of organizational context in Norwegian nursing homes among RNs and LPNs.
Clinical characteristics and outcomes of hospitalized patients with SARS-CoV-2 infection in a Latin American country: Results from the ECCOVID multicenter prospective study
Authors: Cordova Ezequiel , Mykietiuk Analia , Sued Omar , De Vedia Lautaro , Pacifico Natalia , Garcia Hernandez Matias H. , Baeza Natalia M. , Garibaldi Franco , Alzogaray Maria Fernanda , Contreras Rosa , Soler Puy Lucrecia , Scapellato Pablo G. , Barcelona Laura , Golikow Mariana L. , Piñeiro Maria Florencia , Miño Hugo J. , Consalvo Maria Fernanda , Nemirovsky Corina , Sanchez Marisa , Cabral Myrna , Lamponi Tappata Lucia , Blasco Mariano , Ballivian Jamile , Lopardo Gustavo , Stryjewski Martin E. ,   on behalf of the ECCOVID study group
Published: October 2021

Background
Clinical features and outcomes of SARS-CoV-2 infections diverge in different countries. The aim of this study was to describe clinical characteristics and outcomes in a cohort of patients hospitalized with SARS-CoV-2 in Argentina.

Methods
Multicenter prospective cohort study of ≥18 years-old patients with confirmed SARS-CoV-2 infection consecutively admitted to 19 hospitals in Argentina. Multivariable logistic regression models were used to identify variables associated with 30-day mortality and admission to intensive care unit (ICU).

Results
A total of 809 patients were analyzed. Median age was 53 years, 56% were males and 71% had at least one comorbidity. The most common comorbidities were hypertension (32%), obesity (23%) and diabetes (17%). Disease severity at admission was classified as mild 25%, moderate 51%, severe 17%, and critical 7%. Almost half of patients (49%) required supplemental oxygen, 18% ICU, and 12% invasive ventilation. Overall, 30-day mortality was 11%. Factors independently associated with ICU admission were male gender (OR 1.81; 95%CI 1.16–2.81), hypertension (OR 3.21; 95%CI 2.08–4.95), obesity (OR 2.38; 95%CI 1.51–3.7), oxygen saturation ≤93% (OR 6.45; 95%CI 4.20–9.92) and lymphopenia (OR 3.21; 95%CI 2.08–4.95). Factors independently associated with 30-day mortality included age ≥60 years-old (OR 2.68; 95% CI 1.63–4.43), oxygen saturation ≤93% (OR 3.19; 95%CI 1.97–5.16) and lymphopenia (OR 2.65; 95%CI 1.64–4.27).

Conclusions
This cohort validates crucial clinical data on patients hospitalized with SARS-CoV-2 in Argentina.
Drug resistance and its risk factors among extrapulmonary tuberculosis in Ethiopia: A systematic review and meta-analysis
Authors: Diriba Getu , Tola Habteyes Hailu , Alemu Ayinalem , Yenew Bazezew , Gamtesa Dinka Fikadu , Kebede Abebaw 
Published: October 2021

Background
Drug-resistant tuberculosis and extrapulmonary tuberculosis are the world major public health issues. Although some primary studies have been reported on the burden of drug-resistant tuberculosis in extrapulmonary tuberculosis patients in Ethiopia, there is no systematic review and meta-analysis that attempt to summarize the available literature. Thus, we aimed to estimates the prevalence of drug-resistance in extrapulmonary tuberculosis patients and summarize the risk factors associated with the occurrence of extrapulmonary tuberculosis in Ethiopia.

Methods
We conducted a systematic review of the published primary studies on extrapulmonary drug-resistant tuberculosis in Ethiopia.

Results
Eight observational studies were included in this review from different regions of Ethiopia. The overall pooled prevalence of rifampicin resistance was 6% (95% CI 0.03–0.10), while isoniazid resistance was 7% (95% CI 0.03–0.12). The pooled prevalence of multidrug-resistant tuberculosis was 4% (95% CI 0.01–0.07). Previous tuberculosis treatment history and male gender are frequently reported risk factors for developing drug-resistant tuberculosis in extrapulmonary tuberculosis patients.

Conclusion
The current review has identified a high proportion of resistance to rifampicin, isoniazid, and multidrug-resistant tuberculosis in patients with extrapulmonary tuberculosis in Ethiopia. Clinicians should request drug susceptibility testing for all patients with presumptive extrapulmonary tuberculosis to detect drug-resistance.
Quality assured implementation of the Slovenian breast cancer screening programme
Authors: Jarm Katja , Kadivec Maksimiljan , Šval Cveto , Hertl Kristijana , Primic Žakelj Maja , Dean Peter B. , von Karsa Lawrence , Žgajnar Janez , Gazić Barbara , Kutnar Veronika , Zdešar Urban , Kurir Borovčić Mateja , Zadnik Vesna , Josipović Igor , Krajc Mateja 
Published: October 2021

Setting
The organised, population-based breast cancer screening programme in Slovenia began providing biennial mammography screening for women aged 50–69 in 2008. The programme has taken a comprehensive approach to quality assurance as recommended by the European guidelines for quality assurance in breast cancer screening and diagnosis (4th edition), including centralized assessment, training and supervision, and proactive monitoring of performance indicators. This report describes the progress of implementation and rollout from 2003 through 2019.

Methods
The screening protocol and key quality assurance procedures initiated during the planning from 2003 and rollout from 2008 of the screening programme, including training of the professional staff, are described. The organisational structure, gradual geographical rollout, and coverage by invitation and examination are presented.

Results
The nationwide programme was up and running in all screening regions by the end of 2017, at which time the nationwide coverage by invitation and examination had reached 70% and 50%, respectively. Nationwide rollout of the population-based programme was complete by the end of 2019. By this time, coverage by invitation and examination had reached 98% and 76%, respectively. The participation rates consistently exceeded 70% from 2014 to 2019.

Conclusions
The successful implementation of the screening programme can be attributed to an independent central management, external guidance, and strict adherence to quality assurance procedures, all of which contributed to increasing governmental and popular support. The benefits of quality assurance have influenced all aspects of breast care and have provided a successful model for multidisciplinary management of other diseases.
Direct costs of managing in-ward dengue patients in Sri Lanka: A prospective study
Authors: Sigera Chathurani , Rodrigo Chaturaka , de Silva Nipun L. , Weeratunga Praveen , Fernando Deepika , Rajapakse Senaka 
Published: October 2021

Introduction
The cost in managing hospitalised dengue patients varies across countries depending on access to healthcare, management guidelines, and state sponsored subsidies. For health budget planning, locally relevant, accurate costing data from prospective studies, is essential.

Objective
To characterise the direct costs of managing hospitalised patients with suspected dengue infection in Sri Lanka.

Methods
Colombo Dengue Study is a prospective single centre cohort study in Sri Lanka recruiting suspected hospitalised dengue fever patients in the first three days of fever and following them up until discharge. The diagnosis of dengue is retrospectively confirmed and the cohort therefore has a group of non-dengue fever patients with a phenotypically similar illness, managed as dengue while in hospital. The direct costs of hospital admission (base and investigation costs, excluding medication) were calculated for all recruited patients and compared between dengue and non-dengue categories as well as across subgroups (demographic, clinical or temporal) within each of these categories. We also explored if excluding dengue upfront, would lead to an overall cost saving in several hypothetical scenarios.

Results
From October 2017 to February 2020, 431 adult dengue patients and 256 non-dengue fever patients were recruited. The hospitalisation costs were USD 18.02 (SD: 4.42) and USD 17.55 (SD: 4.09) per patient per day for dengue and non-dengue patients respectively (p>0.05). Laboratory investigations (haematological, biochemical and imaging) accounted for more than 50% of the total cost. The costs were largely homogenous in all subgroups within or across dengue and non-dengue categories. Excluding dengue upfront by subsidised viral genomic testing may yield overall cost savings for non-dengue patients.

Conclusion
As non-dengue patients incur a similar cost per day as the dengue patients, confirming dengue diagnosis using subsidised tests for patients presenting in the first three days of fever may be cost-efficient.
ISYU KETUANAN MELAYU DI MALAYSIA
Authors: Marzali Amri 
Published: October 2021

Ketuanan Melayu” is a conception of Malay political hegemony in Malaysia. The terminology was firstly introduced by a member of Parliament of Malaysia from the United Malay National Organization, namely Dato’ Abdullah Ahmad, in a speech offered at the Institute of Intenational Affairs, Singapura, Agustus 30, 1986. The speech was originally aimed at countering the negative propaganda proposed by the Malaysian Indian and the Malaysian Chinese, who accused that the special socio-political privileges given to the indigenous Malaysian peoples in the Malaysia’s Constitution (partaicularly in article 153) and the affirmative discriminative New Economic Policy of 1971 have been a servere strategy to condemn the Indian and Chinese Malaysians. On the other hand, the Malays in Malaysia traced the idea of Malay political hegemony from the political situation in the period of Malay kingdom of Melaka in the 15th century. They considered the period of Melaka as the golden age of Malay political sovereignty in Selat Melaka. When Melaka was occupied by the Portuegese in the 16th century, and followed by the Dutch in the 17-18th centuries, the political sovereignty of the Malays in the Malaysian Peninsula was carried on by the newly subsequent Malay kingdoms, such as Johor, Kedah, Kelantan, and others. In this article, I proposed that what is now called Malay political hegemony could be compared to what was called beschikkingsrecht in Dutch language, in the colonial period of Indonesia. This terminology was introduced by an adat law scholar, van Vollenhoven, in 1905, referring to the sovereignty of the native peoples in Malay Archipelago over their land and political state. Lastly I find the debate on the Malay political hegemony in Malaysia recently, whether between the natives versus the immigrants, or between the ruling Malays versus the opposition Malays, are pertaining with 6 articles in the Constitution and Act of Malaysian Armforce of 1972. This set of rules is knownly called Wasiat Raja-raja Melayu (The Wasiat of the Malay Sultans). Therefore, I conclude, the Malay political hegemony is constitutionalized, thus it is unnecessary for the Malays to boasting it anymore. The real problems of the Malay political hegemony now in Malaysia rests on the way it has been implemented by the Malaysian government.
Nagaraeba – Hegel und Fujiwara no Kiyosuke
Authors: Pörtner Peter 
Published: October 2021

Abstract
Although there is a dispute among grammarians as to whether Japanese is a tense or aspect language, time expressions tend to be made from the perspective of the speaker, i.e. under the aspect of an event that is “now, in this moment already completed, just happening, or not yet happening.” Evidently, the notion of a threefoldedness of time perception is predominant. A comparison of different time concepts and philosophies points towards a transcultural circulation of this notion. Hegel’s philosophy exemplifies the effectiveness and shaping function of this notion of threefold time concepts. Using Fujiwara no Kiyosuke’s poem Nagaraeba, I aim to show how the thesis of the threefoldedness also of the traditional Japanese experience of time, together with the thesis of the aspect orientation of the Japanese language, may help us to interpret and understand classical waka, along the lines of the so-called “fusion of horizons” (Horizontverschmelzung) described by Hans-Georg Gadamer.
A Dataset for Blockholders in US-Listed Firms
Authors: Harries Jan Philipp 
Published: October 2021

Abstract
I introduce a new dataset for research on institutional and individual blockholders in US-listed firms. As of June 2021, the dataset contains 758,666 parsed Form 13D and 13G filings from November 1993 to May 2021, sourced from SEC EDGAR. Due to the semi-structured nature of these filings, a comparable dataset was not available for research before.
Surface Engineering Development Trends and Impact of Surface Coatings and Textures on Automotive Powertrain Friction and Wear Control
Authors: Tung Simon C. , Wong Victor 
Published: October 2021

Abstract
The global automotive industry is facing higher energy costs, more legislative pressure, and an ever-increasing environmental awareness to achieve fuel efficiency and environmental sustainability. In recent years the automotive industry has undergone a revolution in hardware and materials. Among these approaches, engine friction reduction and wear control by surface engineering are the most effective approaches. In this paper, surface engineering and its impact of surface coatings and texture technologies on powertrain components will be reviewed. Recently the lightweight nonferrous alloy and nanocomposites are being incorporated into the emerging powertrain technologies—including a wide range of surface coating materials such as thermal sprayed aluminum liners, diamond-like carbon-coated valve train components, and hard nitride piston rings or composite coatings toward energy-efficient and wear-resistant systems. The major section of this paper will discuss the future development trends of engine friction reduction and wear control by surface modification such as friction-reducing and wear-resistant coatings or surface textures in powertrain components. The impact of surface coatings or surface textures on tribological characteristics will be reviewed. Specifically, this review paper will address the impact of these emerging technologies on engine material requirements. The connection between surface engineering and the emerging powertrain technologies will be described. In summary, this paper will review the impact of emerging surface engineering technologies on tribological performance and future trends for advanced powertrain components. In addition, the bench and engine wear and scuffing assessments will be reviewed in terms of wear and scuffing resistance for a variety of surface coatings or textures applied to engine components. This paper also addresses the interactions between powertrain components and surface coatings or textures and their effects on friction, wear, and engine durability. The increasing importance of surface coatings and textures in engine component design and tribological performance will be fully illustrated.