bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tropomyosin in mugwort cross-reacts to house dust mite, eliciting non-Th2 response in allergic rhinitis patients sensitized to house dust mite
Authors: Duan Su , Zhao Limin , Zhang Yuling , Zhang Nan , Zheng Ming , Wang Qiqi , Zhang Xu , Wang Xiangdong , Ying Sun , Bachert Claus , Zhang Luo , Lan Feng 
Published: April 2021

Abstract
Background
Mugwort and house dust mite (HDM) are two of the most common inhalant allergens in Asia, however, whether mugwort affects polysensitized HDM+ allergic rhinitis (AR) patients has not been elucidated.

Methods
Overall, 15,884 AR outpatients were assessed for clinical status. Amino acid sequences of mugwort were determined by mass spectrometry. Afterward, cross-reactivity between mugwort tropomyosin and Dermatophagoides pteronyssinus 10 (Der p10) was analysed by ELISA inhibition and basophil activation experiments. To compare immunologic responses eliciting by two different tropomyosins, peripheral blood mononuclear cells (PBMCs) of HDM-monosensitized patients were stimulated by mugwort, HDM, Der p10 and synthetic peptides representing mugwort tropomyosin respectively.

Results
Polysensitized HDM+AR patients were mainly sensitized to cat and mugwort, and the positive rate of monosensitized HDM+AR out-clinic patients was increased during the mugwort pollen season. Tropomyosin protein was able to find in mugwort. Synthetic tropomyosin peptide of mugwort activated basophils which were primed by HDM-specific IgE; ELISA inhibition experiment showed synthetic tropomyosin peptide of mugwort inhibited IgE binding to HDM tropomyosin, Der p10. Unlike HDM and Derp 10, mugwort and mugwort tropomyosin mainly induced IFN-γ and IL-17 release in PBMCs of monosensitized HDM+AR patients, but not IL-5.

Conclusions
Pan-allergen tropomyosin accounts for the cross-reactivity between mugwort and HDM, which reminds HDM+ patients to reduce mugwort exposure in mugwort pollen season in virtue of the tropomyosin induced mild inflammation.
Anti-Xa activity and hemorrhagic events under extracorporeal membrane oxygenation (ECMO): a multicenter cohort study
Authors: Descamps Richard , Moussa Mouhamed D. , Besnier Emmanuel , Fischer Marc-Olivier , Preau Sébastien , Tamion Fabienne , Daubin Cédric , Cousin Nicolas , Vincentelli André , Goutay Julien , Du Cheyron Damien 
Published: April 2021

Abstract
Background
Hemorrhagic events remain a major concern in patients under extracorporeal membrane oxygenation (ECMO) support. We tested the association between anticoagulation levels and hemorrhagic events under ECMO using anti-Xa activity monitoring.

Methods
We performed a retrospective multicenter cohort study in three ECMO centers. All adult patients treated with veno-venous (VV)- or veno-arterial (VA)-ECMO in 6 intensive care units between September 2017 and August 2019 were included. Anti-Xa activities were collected until a hemorrhagic event in the bleeding group and for the duration of ECMO in the non-bleeding group. All dosages were averaged to obtain means of anti-Xa activity for each patient, and patients were compared according to the occurrence or not of bleeding.

Results
Among 367 patients assessed for eligibility, 121 were included. Thirty-five (29%) presented a hemorrhagic complication. In univariate analysis, anti-Xa activities were significantly higher in the bleeding group than in the non-bleeding group, both for the mean anti-Xa activity (0.38 [0.29–0.67] vs 0.33 [0.22–0.42] IU/mL; p = 0.01) and the maximal anti-Xa activity (0.83 [0.47–1.46] vs 0.66 [0.36–0.91] IU/mL; p = 0.05). In the Cox proportional hazard model, mean anti-Xa activity was associated with bleeding (p = 0.0001). By Kaplan–Meier analysis with the cutoff value at 0.46 IU/mL obtained by ROC curve analysis, the probability of survival under ECMO without bleeding was significantly lower when mean anti-Xa was > 0.46 IU/mL (p = 0.0006).

Conclusion
In critically ill patients under ECMO, mean anti-Xa activity was an independent risk factor for hemorrhagic complications. Anticoagulation targets could be revised downward in both VV- and VA-ECMO.
Mondor’s disease of the breast: a case series
Authors: Ben Hamida K. , Ghalleb M. , Triki A. , Jebir I. , Makhlouf R. , Touinsi H. 
Published: April 2021

Abstract
Background
Mondor’s disease of the breast (MDB) is a rare and benign disorder of the breast. It is characterized by thrombophlebitis of the superficial veins of the chest wall. Clinically, it manifests as a cord-like induration of the breast area. MDB resolves spontaneously without sequela.

Case presentation
We report cases of three Caucasian African patients aged 29, 40 and 34, respectively. One patient was under progestative contraception. All the patients had a cord-like induration on the chest wall. Ultrasonography was performed in all patients and was normal in two cases and showed a thrombotic vein in one case. All the patients had symptomatic treatment with total resolution of symptoms within 1 to 4 weeks. No relapse was observed.

Conclusion
MDB is benign in most cases. However, it is not to be taken lightly, because it can be the manifestation of an underlying disease such as breast cancer. The diagnosis is based on clinical findings; ultrasonography can be helpful for the diagnosis. Treatment is based on analgesic and anti-inflammatory drugs.
Term gravid uterus in a congenital umbilical hernia: a case report
Authors: Saidi Friday , Rajab Bakari , Chinula Lameck , Kafumba Nomsa , Chagomerana Maganizo , Tang Jennifer H. 
Published: April 2021

Abstract
Background
Umbilical hernias are a frequent and well-known pathology in children or adults. Congenital umbilical hernias are commonly diagnosed in childhood, and in adulthood such a hernia is usually acquired. Umbilical hernia in pregnancy may result in serious obstetric complications including antepartum hemorrhage, intrauterine fetal demise, and preterm labor, particularly if incarcerated.

Case presentation
We present a rare case of a congenital umbilical hernia in a term pregnancy. The patient was a 34-year-old African (Malawian) woman, living with human immunodeficiency virus (HIV) and on antiretroviral treatment, gravida 4, with three previous vaginal deliveries, and with two babies weighing 4 kg at birth. We performed herniorrhaphy at caesarean section, and at 3 months of follow-up she had no evidence of a recurrent hernia.

Conclusion
Congenital umbilical hernias are commonly diagnosed in childhood but might first be seen by medical practitioners in adulthood. A patient-centered approach addressing patient complaints, associated risk factors, and possible complications is recommended. Primary repair at caesarean section is a feasible option.
Conditions for the validity of a class of optimal Hilbert type multiple integral inequalities with nonhomogeneous kernels
Authors: He Bing , Hong Yong , Li Zhen 
Published: April 2021

AbstractFor the Hilbert type multiple integral inequality$$ \int _{\mathbb{R}_{+}^{n}} \int _{\mathbb{R}_{+}^{m}} K\bigl( \Vert x \Vert _{m,\rho }, \Vert y \Vert _{n, \rho }\bigr) f(x)g(y) \,\mathrm{d} x \,\mathrm{d} y \leq M \Vert f \Vert _{p, \alpha } \Vert g \Vert _{q, \beta } $$∫R+n∫R+mK(∥x∥m,ρ,∥y∥n,ρ)f(x)g(y)dxdy≤M∥f∥p,α∥g∥q,βwith a nonhomogeneous kernel$K(\|x\|_{m, \rho }, \|y\|_{n, \rho })=G(\|x\|^{\lambda _{1}}_{m, \rho }/ \|y\|^{\lambda _{2}}_{n, \rho })$K(∥x∥m,ρ,∥y∥n,ρ)=G(∥x∥m,ρλ1/∥y∥n,ρλ2)($\lambda _{1}\lambda _{2}> 0$λ1λ2>0), in this paper, by using the weight function method, necessary and sufficient conditions that parametersp,q,$\lambda _{1}$λ1,$\lambda _{2}$λ2,α,β,m, andnshould satisfy to make the inequality hold for some constantMare established, and the expression formula of the best constant factor is also obtained. Finally, their applications in operator boundedness and operator norm are also considered, and the norms of several integral operators are discussed.
HIV incidence among men who have sex with men using geosocial networking smartphone application in Beijing, China: an open cohort study
Authors: Mi Guo-Dong , Zhang Bin-Bin , Yu Fei , Ren Xian-Long , Ong Jason J. , Fan Ya-Qi , Guo Feng-Hua , Li Chun-Jun , Zhang Mian-Zhi , Zhang Min-Ying 
Published: April 2021

Abstract
Background
Sexual transmission among men who have sex with men (MSM) is the dominant route of HIV transmission in China. Extensive use of geosocial networking (GSN) smartphone application (app) has dramatically changed the pattern of sexual behaviors and HIV risk among MSM, but data on HIV incidence and the changing risk behaviors of GSN app-using MSM are limited. We aims to assess the HIV incidence and its correlates among gay GSN app-using MSM in China.

Methods
We constructed an open cohort which was initiated and maintained using a GSN app to assess the HIV incidence among app-using MSM, recruited from June 2017 to December 2018. MSM completed an online questionnaire on their sociodemographic characteristics, sexual behaviors, recreational drug use and sexually transmitted infections status. Then each man had an HIV test, and those tested negatives were enrolled into the cohort. Participants completed follow-ups with additional HIV tests though the app during the study period, and were censored at HIV seroconversion or study end date. HIV incidence was calculated by dividing the sum of observed HIV seroconversions by the observed person-time. Univariate (Chi-square test and Fisher’s exact test) and multivariate (proportional hazards regression) analyses were used to examine correlates of HIV incidence.

Results
A total of 6957 HIV negative MSM were enrolled in the open cohort, 37 seroconversions occurred among 1937 men contributing 1065 observed person-years: HIV incidence was 3.47 per 100 person-years [95% confidence interval (CI): 2.37–4.57]. More than five sexual partners [hazard ratio (HR) = 2.65, 95% CI: 1.04–6.67], and sex with HIV positive partners (HR = 3.82, 95% CI: 1.16–12.64) in the preceding six months were positively associated with HIV seroconversion. Consistent condom use for anal sex (HR = 0.27, 95% CI: 0.07–0.96), and reporting insertive anal sex only (HR = 0.23, 95% CI: 0.08–0.62) in the preceding six months were protective factors for HIV seroconversion.

Conclusions
Tailored interventions targeting app-using MSM are urgently needed given their high risk of HIV. As a new tool for accessing MSM at higher HIV risk, GSN smartphone app could play an important role in HIV research among MSM.
Internet of things issues related to psychiatry
Authors: Monteith Scott , Glenn Tasha , Geddes John , Severus Emanuel , Whybrow Peter C. , Bauer Michael 
Published: April 2021

Abstract
Background
Internet of Things (IoT) devices for remote monitoring, diagnosis, and treatment are widely viewed as an important future direction for medicine, including for bipolar disorder and other mental illness. The number of smart, connected devices is expanding rapidly. IoT devices are being introduced in all aspects of everyday life, including devices in the home and wearables on the body. IoT devices are increasingly used in psychiatric research, and in the future may help to detect emotional reactions, mood states, stress, and cognitive abilities. This narrative review discusses some of the important fundamental issues related to the rapid growth of IoT devices.

Main body
Articles were searched between December 2019 and February 2020. Topics discussed include background on the growth of IoT, the security, safety and privacy issues related to IoT devices, and the new roles in the IoT economy for manufacturers, patients, and healthcare organizations.

Conclusions
The use of IoT devices will increase throughout psychiatry. The scale, complexity and passive nature of data collection with IoT devices presents unique challenges related to security, privacy and personal safety. While the IoT offers many potential benefits, there are risks associated with IoT devices, and from the connectivity between patients, healthcare providers, and device makers. Security, privacy and personal safety issues related to IoT devices are changing the roles of manufacturers, patients, physicians and healthcare IT organizations. Effective and safe use of IoT devices in psychiatry requires an understanding of these changes.
Transdiagnostic comparison of visual working memory capacity in bipolar disorder and schizophrenia
Authors: Barnes-Scheufler Catherine V. , Passow Caroline , Rösler Lara , Mayer Jutta S. , Oertel Viola , Kittel-Schneider Sarah , Matura Silke , Reif Andreas , Bittner Robert A. 
Published: April 2021

Abstract
Background
Impaired working memory is a core cognitive deficit in both bipolar disorder and schizophrenia. Its study might yield crucial insights into the underpinnings of both disorders on the cognitive and neurophysiological level. Visual working memory capacity is a particularly promising construct for such translational studies. However, it has not yet been investigated across the full spectrum of both disorders. The aim of our study was to compare the degree of reductions of visual working memory capacity in patients with bipolar disorder (PBD) and patients with schizophrenia (PSZ) using a paradigm well established in cognitive neuroscience.

Methods
62 PBD, 64 PSZ, and 70 healthy controls (HC) completed a canonical visual change detection task. Participants had to encode the color of four circles and indicate after a short delay whether the color of one of the circles had changed or not. We estimated working memory capacity using Pashler’s K.

Results
Working memory capacity was significantly reduced in both PBD and PSZ compared to HC. We observed a small effect size (r = .202) for the difference between HC and PBD and a medium effect size (r = .370) for the difference between HC and PSZ. Working memory capacity in PSZ was also significantly reduced compared to PBD with a small effect size (r = .201). Thus, PBD showed an intermediate level of impairment.

Conclusions
These findings provide evidence for a gradient of reduced working memory capacity in bipolar disorder and schizophrenia, with PSZ showing the strongest degree of impairment. This underscores the importance of disturbed information processing for both bipolar disorder and schizophrenia. Our results are compatible with the cognitive manifestation of a neurodevelopmental gradient affecting bipolar disorder to a lesser degree than schizophrenia. They also highlight the relevance of visual working memory capacity for the development of both behavior- and brain-based transdiagnostic biomarkers.
Single-leg hop distance normalized to body height is associated with the return to sports after anterior cruciate ligament reconstruction
Authors: Ohji Shunsuke , Aizawa Junya , Hirohata Kenji , Ohmi Takehiro , Mitomo Sho , Jinno Tetsuya , Koga Hideyuki , Yagishita Kazuyoshi 
Published: April 2021

Abstract
Purpose
To investigate the relationship between single-leg hop distance (SLHD), normalized body height, and return-to-sports (RTS) status after anterior cruciate ligament reconstruction (ACLR) and to identify the cut-off value for SLHD on the operated side.

Methods
Seventy-three patients after primary ACLR (median 13.5 months) participated in this cross-sectional study. Participants were divided into ‘‘Yes-RTS’’ (YRTS) or ‘‘No-RTS’’ (NRTS) groups based on a self-reported questionnaire. SLHD was measured, and the limb symmetry index (LSI) and SLHD (%body height) were calculated. A minimum p-value approach was used to calculate the SLHD cut-off points (%body height) on the operated side that were strongly associated with the RTS status. Logistic regression analysis was used to analyse the association between RTS status and SLHD cut-off point (%body height). Isokinetic strength and Tampa scale for kinesiophobia (TSK) were measured as covariates.

Results
Among 73 patients, 43 (59%) were assigned to the YRTS and 30 (41%) to the NRTS group. The 70% body height cut-off point for SLHD on the operated side was most strongly associated with RTS status. In a logistic regression analysis including other covariates, SLHD (%body height) < 70% and TSK were negatively associated with RTS status. Except for two participants, the LSI of the SLHD exceeded 90% and there was no significant association between the LSI of the SLHD and RTS status.

Conclusion
Even after improvement in the LSI of the SLHD, planning rehabilitation with the goal of achieving SLHD over 70% body height may be important for supporting RTS after ACLR.

Level of evidence
Cross-sectional study, Level IV
Observation of dose dependent intravaginal Prostaglandin E2 application in free farrowing sows during parturition – a pilot study
Authors: Grahofer Alexander , Bill Ramona , Nathues Heiko 
Published: April 2021

AbstractThe duration of birth is an important factor influencing the survival of piglets and the health of sows. A prolonged parturition is usually treated with oxytocin, even though several undesirable side effects are described. Therefore, the aim of this study was to evaluate the safety and efficacy of Prostaglandin E2 (PGE2) of different concentrations as an intravaginal applied gel after the birth of the fourth piglet in sows. Twelve sows were randomly allocated to one of four treatment groups: Group I (control group) application of placebo gel; Group II application of 0.5 mg; Group III application of 1.0 mg PGE2; Group IV PGE2 application of 2.0 mg PGE2. Total duration of parturition (time between first piglet and last placenta), piglet interval before and after treatment and placenta expulsion duration (time between first and last placenta) were recorded, and each piglet was scored for meconium staining and vitality. Furthermore, stillborn piglets were categorized into ante-partum and intra-partum deaths.A significant dose-dependent effect of PGE2 after the fourth piglet in a linear regression model with group I, II and III on the total duration of parturition and the placenta expulsion duration was detected. An increase of the PGE2 dosage from 0 to 1 mg significantly reduced the total duration of parturition (group I: 553.7 ± 114.2; group II:456 ± 167.9; group III: 284.7 ± 40.5; p-value: 0.02) and placenta expulsion duration (group I: 364 ± 120; group II: 289 ± 144.1; group III: 119 ± 46.13; p-value: 0.03). Although no further significant differences between the groups using ANCOVA and a linear regression model including all groups were detected, severe meconium staining in more than 10% of piglets was observed in group II and IV. Moreover, piglets of group IV showed oedematous and haemorrhagic umbilical cords, lethargy and anoxia after treatment, and intra-partum deaths were recorded.The best outcome for the sows and piglets was achieved using the 1 mg PGE2 dosage, whereas the other dosages showed more negative side effects, impairing the health and welfare of the animals. The results of this study can be used for further studies with larger sample sizes.
A wavelet approach of investing behaviors and their effects on risk exposures
Authors: Mestre Roman 
Published: April 2021

AbstractExposure to market risk is a core objective of the Capital Asset Pricing Model (CAPM) with a focus on systematic risk. However, traditional OLS Beta model estimations (Ordinary Least Squares) are plagued with several statistical issues. Moreover, the CAPM considers only one source of risk and supposes that investors only engage in similar behaviors. In order to analyze short and long exposures to different sources of risk, we developed a Time–Frequency Multi-Betas Model with ARMA-EGARCH errors (Auto Regressive Moving Average Exponential AutoRegressive Conditional Heteroskedasticity). Our model considers gold, oil, and Fama–French factors as supplementary sources of risk and wavelets decompositions. We used 30 French stocks listed on the CAC40 (Cotations Assistées Continues 40) within a daily period from 2005 to 2015. The conjugation of the wavelet decompositions and the parameters estimates constitutes decision-making support for managers by multiplying the interpretive possibilities. In the short-run, (“Noise Trader” and “High-Frequency Trader”) only a few equities are insensitive to Oil and Gold fluctuations, and the estimated Market Betas parameters are scant different compared to the Model without wavelets. Oppositely, in the long-run, (fundamentalists investors), Oil and Gold affect all stocks but their impact varies according to the Beta (sensitivity to the market). We also observed significant differences between parameters estimated with and without wavelets.
The impact of the COVID-19 outbreak on Chinese-listed tourism stocks
Authors: Wu Wenmin , Lee Chien-Chiang , Xing Wenwu , Ho Shan-Ju 
Published: April 2021

AbstractThis research explored the effects of the coronavirus disease (COVID-19) outbreak on stock price movements of China’s tourism industry by using an event study method. The results showed that the crisis negatively impacted tourism sector stocks. Further quantile regression analyses supported the non-linear relationship between the government’s responses and stock returns. The results present that the resurgence of the virus in Beijing did bring about a short-term negative impact on the tourism industry. The empirical results can be used for future researchers to conduct a comparative study of cultural differences concerning government responses to the COVID-19.
Electrical control strategy for an ocean energy conversion system
Authors: Noman Muhammad , Li Guojie , Wang Keyou , Han Bei 
Published: April 2021

AbstractGlobally abundant wave energy for power generation attracts ever increasing attention. Because of non-linear dynamics and potential uncertainties in ocean energy conversion systems, generation productivity needs to be increased by applying robust control algorithms. This paper focuses on control strategies for a small ocean energy conversion system based on a direct driven permanent magnet synchronous generator (PMSG). It evaluates the performance of two kinds of control strategies, i.e., traditional field-oriented control (FOC) and robust adaptive control. The proposed adaptive control successfully achieves maximum velocity and stable power production, with reduced speed tracking error and system response time. The adaptive control also guarantees global system stability and its superiority over FOC by using a non-linear back-stepping control technique offering a better optimization solution. The robustness of the ocean energy conversion system is further enhanced by investigating the Lyapunov method and the use of a DC-DC boost converter. To overcome system complexity, turbine-generator based power take-off (PTO) is considered. A Matlab/Simulink study verifies the advantages of a non-linear control strategy for an Oscillating Water Column (OWC) based power generation system.