bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Facile Green Synthesis of Nickel Ferrite Nanoparticles using Tamarindus Indica Seeds for Magnetic and Photocatalytic Studies
Authors: NAIK M MADHUKARA , Vinuth M , Kumar V. Udaya , Hemakumar K. H. , Preethi G , Kumar M Prathap , Nagaraju G 
Published: June 2021

Abstract
Magnetic NiFe2O4 nanoparticle (NFNPs) was synthesized by the microwave-assisted method using Tamarindus indica seeds as a green reducing agent. The identification of NFNPs was carried out by XRD, FTIR, SEM with EDAX analysis, UV-Visible Spectroscopic and luminescence techniques. Spinel structure of NFNPs with a single phase has been confirmed by XRD with an average crystallite size of 21 nm. FTIR confirms the presence of tetrahedral and octahedral sites of prepared NFNPs. SEM with EDAX and TEM gives the information of agglomeration of magnetic nanoparticles with elemental composition present in the NFNPs and spherical nature of nanoparticles with a particle size of 29 nm. The prepared NFNPs are visible active with band gap of 1.92 eV. NFNPs show effective photocatalytic activity under visible light irradiation towards the degradation of anionic Alizarin red S dye and cationic Methylene Blue dye. NFNPs show good magnetic property in VSM studies. The prepared NFNPs can be useful for wastewater treatment.
Environmental Factors Determinate Roadkill Levels of the Endemic Iberian Species, Iberian Hare (Lepus Granatensis)
Authors: Duarte Jesús , Romero David , Rubio Pablo , Farfán Miguel Ángel , Fa Julia 
Published: June 2021

Abstract
Lepus granatensis is an Iberian Peninsula endemic species and one of the most important small game species. We surveyed Iberian hare-vehicle accidents in roads network in southern Spain, analysing the Mediterranean landscape, the main habitats of this species. We recorded roadkill of roads during 6-month, compared hare roadkill densities to hare hunting yields. We analyzed the spatial patterns and factors that could be influencing the hare road kill. We detected blackspots of hare road kill in areas with high landscape heterogeneity and included embankments, intersections roads and high traffic intensity. The hare roadkill ranged between 6% and 41% of the annual harvest of hares killed on neighbouring hunting estates. We therefore consider it highly relevant to take into account the hare road kill, especially in hare hunting areas, suggesting to gamekeepers and managers addressing the issue of road kill of hares. It would be necessary that hunting quotas be adjusted in territories where the additive effect of these non-natural hare mortalities converge. Results point to future directions for applied research in road ecology, which would include demographic compensation and roadkill mitigation. Our methodology could be of wide use to identify lagomorphs’ road kill blackspots by analysing environmental spatial patterns.
Rivaroxaban versus Vitamin K Antagonists (Warfarin) based on the triple therapy for left ventricular thrombus after ST-Elevation Myocardial Infarction
Authors: Zhang Zhongfan , Zhang Qian , Qu Ming , Yu Miao , Jiang Zhenya , Li Delin , Si Daoyuan , Zhang Wenqi 
Published: June 2021

Abstract
Background: Left ventricular thrombus(LVT) can lead to serious complications, and mostly formed after ST-Elevation myocardial infarction(STEMI). The Off-label use of new oral anticoagulants(NOACs) in the triple therapy of LVT after STEMI has increased in the past few years. As one of the most widely used NOACs, the data of safety and efficacy of rivaroxaban in LVT after STEMI is limited and warrants continued exploring.Methods: We conducted a retrospective cohort study involving STEMI patients underwent primary percutaneous coronary intervention (PCI). Among patients who developed LVT after STEMI, we evaluated the efficacy and safety of rivaroxaban plus DAPT therapy associated with thrombus resolution and clinical adverse events, compared with triple therapy with VKA. Results: In 1,335 patients with STEMI, a total of 77 (5.7%) developed LVT over the follow up period (median 25.0 months). Of the patients diagnosed with LVT, 31 patients were started on triple therapy with VKA, 33 patients on triple therapy with rivaroxaban. There was a consistent similarity in LVT resolution with rivaroxaban application compared to VKA application during the follow-up period[HR:1.57(95%CI 0.89-2.77), p=0.096; Adjusted HR:1.70(95%CI 0.90-3.22), p=0.104]. When the analysis focused on LVT resolution at different time points during the follow-up period, triple therapy with rivaroxaban showed quicker resolution than with VKA(6months:p=0.049; 12months:p=0.044; 18months:p=0.045). Meanwhile, similar risks of ISTH bleeding were recorded in both groups, with no difference between the two groups(Rivaroxaban 6.1% vs VKA 9.7% , p=0.444). Fewer net adverse clinical events(NACE) were observed in the rivaroxaban group compared with the VKA group[Rivaroxaban 24.2% vs VKA 58.1%; HR:0.31(95%CI 0.14-0.68), p=0.003; Adjusted HR: 0.23(95%CI 0.09-0.57), p=0.001].Conclusions: This observational study suggests triple therapy with rivaroxaban has similar and quicker LVT resolution in patients with LVT after STEMI, compared with triple therapy with VKA, and perhaps was accompanied with a better clinical benefit. Larger sample sizes and randomized controlled trials are needed to confirm this observation.
Morphological Analysis of Medullary Cavity for Designing Personalized Femoral Stem
Authors: Wang Lin , Guo Kaijin , Zhu Hong , He Kunjin , Geng Weizhong 
Published: June 2021

Abstract
To improve the quality and efficiency of femoral stem prosthesis design, a Monte Carlo method based on femoral bone marrow cavity analysis is proposed to measure morphological parameters using anatomical semantics. The region of interest is the femur, which includes the medullary cavity and cortical region. After this region is extracted, the size of the cavity and region is simulated using the Monte Carlo method. Finally, based on clinical needs, the morphological parameters are calculated and analyzed based on the size of the region of interest. From the perspective of the probability model, the non-random problem of solving the cross-section area of the femoral marrow cavity is transformed into one having a random nature so that a probability model can be used. The experimental results show that this method is simple, flexible, and efficient. It provides a new and reasonable scientific method for comprehensively understanding the anatomical morphological changes of the femoral marrow cavity. The measurement and analysis of the morphological parameters of the femoral bone marrow cavity in this paper provide the necessary scientific theoretical support for improved morphologic research, design, and clinical selection of femoral stem prostheses and has important significance and application value in clinical practice.
Vertical distribution and sources of PAHs in different agricultural soil profiles: a case study in Jianghan Plain, Central China
Authors: Wang Zeya , Gong Xiangyi , Zhang Jiaquan , Ren Dajun , Meng Dekang 
Published: June 2021

Abstract
PAHs are one of the persistent organic pollutants (POPs) and widely distributed in nature. This study aimed to investigate the distribution and origination of polycyclic aromatic hydrocarbons (PAHs) in 3 different agricultural soil profiles (paddy, cotton and rape). The study found that 16 PAHs were all detected in 3 soil profiles, where the concentrations of ∑16PAHs ranged from 122.37-664.13ng/g in surface soil and 24.15-109.76ng/g in bottom soil. Compared to other areas, the concentrations were higher than most plains, but lower than several cities. The ∑16PAHs of naphthalene(Nap) counted the most in nearly every sample. The total concentrations of ∑16PAHs were higher in shallow soil and decreased sharply with the increase of depth, while those were smoothly distributed in paddy field (PF). The results showed that 3 soil profiles were all weakly alkaline (8 < pH < 9), and PAH concentrations in soil were linearly related with total organic carbon (TOC) at different depths except for the PF soil profiles. It was the flooded tillage method in PF that caused the different characteristics of distribution and physicochemical properties. There were high correlation between dissolved organic matters(DOM) and PAH concentrations in cotton field (CF). However, there were no correlations between concentrations of PAHs and other 3 properties (pH, clay miners). By the ratio method, PAHs were revealed mainly derived from combustion, and then petroleum.
Pilot Program of Shared Assistance with Primary Care in Patients Living with HIV, and Satisfaction with The Healthcare Received
Authors: Riera Melchor , Ferre Adria , Santos-Pinheiro Alfredo , Vilchez Helem Hayde , Martin-Peña Maria Luisa , Ribas Maria Angels , Peñaranda Maria , Fanjul Francisco Javier , Campins Antoni Abdo , Pou Joan Albert , Garcia-Gazalla Mercedes , Pou Joan , Llorente Maria Angeles , Garcia-Paz Maria del carmen , Corredor Maria Teresa , Estelrich Catalina Maria , Gomez-Lobon Ana , Murillas Javier 
Published: June 2021

Abstract
Background: There are few shared assistance programs with Primary Health Care (PHC) in PLWH. The aim was to develop a Pilot Program of shared HIV care in PLWH ensuring proper HIV control. Methods: Design: Prospective pilot project of a shared care intervention.Setting: HIV specialized outpatient consultations for HIV infection at Son Espases University Hospital which serves 2000 patients. Subjects: Patients who attended HIV specialized consultation between January 1st and June 30th, 2017. Intervention: Basal questionnaire on health services used by patients. HIV Training Program on HIV in Primary Health Care (PHC). Pilot Program of shared assistance (PPAC) with PHC. Main Outcomes: Maintenance of undetectable HIV viral load, antiretroviral therapy (ART) adherence, AIDS and non-AIDS events, loss of follow up, and satisfaction questionnaire. Results: The basal questionnaire was filled out by 918 patients, with 108 (11.7%) patients reporting neither knowing nor having been visited by their GP. A total of 93 patients were included in the PPAC, with a mean age of 49.9 years (SD 11.7), and an average of 14.6 years since the HIV diagnosis. Eleven patients were followed up for less than six months and were excluded from the analysis. Median follow-up during the PPAC of the remaining 82 patients was 728 days (IQR 370-1070). Sixteen patients dropped out of the PPAC (19.5%), three died, three were lost to follow up, one was withdrawn due to medical criteria, and nine withdrew voluntarily.No patient presented any AIDS defining events, although eight patients presented non-AIDS events. All the patients had undetectable viral load (VL) and average ART adherence was 99.4% (SD1.4). The patient’s satisfaction score with PPAC was 8.64 (SD2.5).Conclusion: It is possible to establish shared care programs with PHC in selected patients with HIV infection, thereby reducing hospital visits while maintaining good adherence and virological control and achieving high patient satisfaction.
Utilization of both Electronical Manganese Slag and Silicate Tailings as Raw Materials for Fabrication of Cost-effective Porous Ceramics
Authors: Lin Hongfu , Li Mengke , He Zhiguo , Zhong Hui , Hu Liang , Sun Wei , Zhang Dajun 
Published: June 2021

Abstract
Herein, porous wollastonite ceramics with high porosity and low density were successfully fabricated with silicate tailings and electrolytic manganese slag (MS) as primary raw materials. The influences of calcination temperature, SiC and MS addition amounts on porosity, water adsorption, pore distribution, bulk density and bending strength were systematically studied. The results showed that 0.4 wt% of SiC was optimal for the ceramic foaming at the sintering temperature of 1140 ℃. The addition of MS promoted the foaming of ceramic matrix at low temperature. The porosity of ceramics reduced from 78.4–63.7%, bulk density elevated from 0.96 to 1.13 g/cm3, and bending strength increased from 8.43 to 11.22 MPa as the MS increased from 8.33 wt% to 46.67 wt%. Moreover, the best corrosion resistance performance reached to 99.55% with 8.33 wt% MS content and sintering temperature of 1160 ℃. This work is of significance for the solid waste utilization.
Knowledge assessment of Sepsis Diagnosis and Management during COVID-19 pandemic among House Officers &amp; Medical Officers in Ibrahim Malik Teaching Hospital in Khartoum State, Sudan, 2021
Authors: Abdelrahman ElMuiz , Ahmed Khabab Abbasher Hussien Mohamed , Mahgoub Ibrahim , Omer Mohammed Eltahier Abdalla , Abdalla Yassin Abdelrahim , Bashir Abdelgadir Ali 
Published: June 2021

Abstract
Background: Sepsis is life-threatening and frequently a final common pathway to death for many infectious diseases worldwide and may lead to death if left untreated. The objective is to assess the scientific medical knowledge upon sepsis among House officers and Medical officers in terms of diagnosis and management.Method: An observational cross sectional Hospital-based study was conducted through self-administered retrospective questionnaires based on the objective of the study. We enrolled 155 participants through Convenience sampling. The questionnaire contains parts of validated Sepsis criteria in terms of diagnosis and management. Analysis was done by using SPSS version 20. Data are presenter as frequencies and percentages using figures and tables. P value less than 0.05 considered significant Mann Whitney U test use to compare level of knowledge adherence between trained participants and non-trained participants.Results: The mean knowledge score about sepsis diagnosis was 2.6 out of 10 (SD= 1.8), and about sepsis management was 2.8 out of 8 (SD=1.8) the mean overall score was 5.5 out of 18.No significant difference found between participants who were trained upon diagnosis and management of sepsis and those who were not.Conclusion: Study findings illustrated that the capacity to perceive and manage sepsis among House Officers and Medical Officers doctors is poor and there are dangerous gaps in their investigation and management of such septic patients.
Investigation of the Role of CpG Methylation in Epithelial Mesenchymal Transition Master Genes in a Chemoresistant Ovarian Cancer Cell line
Authors: Alghamian Yaman , Soukkarieh Chadi , Abbady Abdul Qader , Murad Hossam 
Published: June 2021

Abstract
Ovarian cancer is one of the commonly diagnosed cancers among women. Chemoresistant is an essential reason for treatment failure and high mortality. Emerging evidence connects epithelial mesenchymal transition (EMT) like changes and acquisition of chemoresistance in cancer. DNA methylation influences cellular processes including EMT. Here, we investigate EMT like changes in cisplatin-resistant A2780 ovarian cancer cells (A2780cis), and we study the DNA methylation role in EMT master genes regulation. Cell viability assay was carried to test the sensitivity of A2780, and A2780cis human cancer cell lines to cisplatin compared to other cancer cell lines. Differential mRNA expression of EMT markers using qPCR was conducted to investigate EMT like changes. The role of CpGs methylation in gene expression regulation was investigated by 5-azacytidine (5-aza) treatment. DNA methylation changes in EMT genes were identified using Methylscreen assay between A2780 and A2780cis cells. A2780cis maintains its cisplatin tolerance ability and exhibits phenotypic changes congruent with EMT. Methylscreen assay and qPCR study revealed DNA hypermethylation in promoters of epithelial adhesion molecules CDH1 and EPCAM in A2780cis compared to the cisplatin-sensitive parental cells, these changes were concomitant with gene expression down-regulation. DNA hypomethylation associated with transcription up-regulation of the mesenchymal marker TWIST2 was observed in the resistant cells. Azacytidine treatment confirmed the DNA methylation role in the regulation of gene expression of CDH1, EPCAM and TWIST2 genes. A2780cis cell line undergoes EMT like changes, and EMT master genes are regulated by DNA methylation. A better perception of the molecular alterations which correlate with chemoresistance may lead to therapeutic benefits such as chemosensitivity restoration.
Identification of SARS-CoV-2 P.1-related lineages in Brazil provides new insights about the mechanisms of emergence of Variants of Concern
Authors: Gräf Tiago , Bello Gonzalo , Venas Taina Moreira Martins , Pereira Elisa Cavalcante , Paixão Anna Carolina Dias , Appolinario Luciana Reis , Lopes Renata Serrano , Mendonça Ana Carolina da Fonseca , Rocha Alice Sampaio Barreto da , Motta Fernando Couto , Gregianini Tatiana Schäffer , Salvato Richard Steiner , Fernandes Sandra Bianchini , Rovaris Darcita Buerger , Cavalcanti Andrea Cony , Leite Anderson Brandão , Riediger Irina , Debur Maria do Carmo , Bernardes André Felipe Leal , Ribeiro-Rodrigues Rodrigo , Grinsztejn Beatriz , Nascimento Valdinete Alves do , de Souza Victor Costa , Gonçalves Luciana , Costa Cristiano Fernandes da , Mattos Tirza , Dezordi Filipe Zimmer , Wallau Gabriel Luz , Naveca Felipe Gomes , Delatorre Edson , Siqueira Marilda Mendonça , Resende Paola Cristina 
Published: June 2021

Abstract

One of the most remarkable features of the SARS-CoV-2 Variants of Concern (VOC) is the unusually large number of mutations they carry. However, the specific factors that drove the emergence of such variants since the second half of 2020 are not fully resolved. In this study, we described a new SARS-CoV-2 lineage provisionally designated as P.1-like-II that, as well as the previously described lineage P.1-like-I, shares several lineage-defining mutations with the VOC P.1 circulating in Brazil. Reconstructions of P.1 ancestor sequences demonstrate that the entire constellation of mutations that define the VOC P.1 did not accumulate within a single long-term infected individual, but was acquired by sequential addition during interhost transmissions. Our evolutionary analyses further estimate that P.1-ancestors strains carrying half of the P.1-lineage-defining mutations, including those at the receptor-binding domain of the Spike protein, circulated cryptically in the Amazonas state since August 2020. This evolutionary pattern is consistent with the hypothesis that partial human population immunity acquired from natural SARS-CoV-2 infections during the first half of 2020 might have been the major driving force behind natural selection that allowed VOCs' emergence and worldwide spread. These findings also support a long lag-time between the emergence of variants with key mutations of concern and expansion of the VOC P.1 in Brazil.
Tendencies in the propagation of fires and ammunition explosions at fixed storage facilities
Authors: Zlobin V. А. 
Published: June 2021

Aim. To suggest an approach to identifying the common features of statistical series containing information on the time, place and external conditions of the development and propagation of emergency situations associated with fires and ammunition explosions at fixed storage facilities, to synthesize the function of partial risk indicator of such situations, i.e., the energy susceptibility to external effects of ammunition storage systems. Methods. The paper uses methods of mathematical analysis of statistical series and probability theory. For the first time ever, individual external conditions of emergency situations involving ammunition are analysed using statistical series (rate of insolation). Results. The paper has collected and classified statistical data on emergencies involving fires and explosions in ammunition storage facilities that took place in the current century in a number of countries of the world, whose emergency nature was confirmed by extensive media coverage. Using statistical series analysis, an exponential relationship has been established between the rate of fires and explosions and the total power saturation of the ammunition storage system. Conclusions. The frequency of emergencies involving fires and explosions depends on the overall power saturation of the storage system that is defined by the solar intensity in the area of the ammunition storage facility that depends on its latitude and season. The suggested approach allows, by analysing empirical data on the time and place of emergencies, identifying the specific survivability values of a hazardous storage facility characterizing the energy susceptibility of the system to the effects that trigger explosions and fires.
Immunosuppressant Drugs and Covid-19: Associated Risks, Drug-Drug Interactions and Contraindications
Authors: Talukdar Debjyoti , Ignacio Diane , Gupta Madan Mohan 
Published: June 2021

:
Immunosuppressant drugs like Etanercept, Mycophenolate mofetil, Sirolimus, Cyclosporine,
and Rituximab can weaken the immune system and make patients susceptible to SARS
nCoV-2 virus. These drugs make immunocompromised persons more vulnerable to complications
associated with COVID-19. Moreover, it can also increase mortality and morbidity, as a weakened
immune system can lead to a longer duration of infection. This study discusses the guidelines on
immunosuppressant drugs and their associated risk factors with COVID-19, issued by the U.S
CDC (Centers for Disease Control and Prevention), WHO (World Health Organization), U.S FDA
(Food and Drug Administration), and other accredited global health organizations. Moreover, it also
includes information about pharmaceutical properties, mechanism of action, COVID-19 associated
risk factors, adverse drug reactions, contraindications, and drug-drug interactions. Our study
will help government partners and international health organizations to understand COVID-19
health risks associated with immunosuppressants. Increased public awareness about effective drug
therapy for autoimmune diseases, cancer treatment, immunocompromised, and organ transplant patients
will help lower the mortality and morbidity associated with the disease amid the COVID-19
pandemic.
Vicisitudes de la práctica de enfermería ante la Covid-19
Authors: Orozco-López O.V. 
Published: June 2021

Lejano parece el mes de enero cuando estábamos saliendo de las festividades decembrinas y con gran expectativa y emoción recibíamos un año nuevo. Iniciaba el 2020, especial pues es nuestro Año Internacional de los Profesionales de la Enfermería y de la Partería, designado así por la 72ª Asamblea Mundial de la Salud en conmemoración del bicentenario del natalicio de Florence Nightingale.
Sin embargo, a inicios de este año la OMS reportó la existencia de un brote de neumonía atípica en la ciudad china de Wuhan. Se trataba del surgimiento de lo que posteriormente sería la pandemia de la Covid-19.
El proceso de reconversión de las unidades que prestaron atención a pacientes con Covid fue el primero de muchos retos que el personal de salud que tuvimos que enfrentar.