bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between statin use and 30-day mortality among patients with sepsis-associated encephalopathy: a retrospective cohort study
Authors: Chen Junwei , Chen Junde , Li Lihong 
Published: December 2024

AimSepsis-associated encephalopathy (SAE) is a common and serious complication of sepsis with poor prognosis. Statin was used in SAE patients, whereas its effects on these patients remain unknown. This study is aimed at investigating the impact of statins on the 30-day mortality of patients with SAE.MethodsIn this retrospective cohort study, data from SAE patients were extracted from the Medical Information Mart for Intensive Care IV (MIMIC-IV). Statins include atorvastatin, pravastatin, rosuvastatin, and simvastatin. The outcome was 30-day mortality of SAE patients starting 24 h after the first intensive care unit (ICU) admission and at the first time after hospitalization. Potential covariates (sociodemographic characteristics, vital signs, score indexes, laboratory parameters, comorbidities, and treatment intervention methods) were selected using univariate Cox proportional hazard analysis. Associations between statin use and statin type and 30-day mortality were explored using univariate and multivariate Cox proportional hazard models with hazard ratios (HRs) and 95% confidence intervals (CIs). Associations were further explored in different age groups, sex, sequential organ failure assessment (SOFA), simplified acute physiology score II (SAPS II), and systemic inflammatory response syndrome (SIRS) populations.ResultsA total of 2,729 SAE patients were included in the study, and 786 (28.8%) died within 30 days. Statin use was associated with lower odds of 30-day mortality (HR = 0.77, 95%CI: 0.66–0.90) in all SAE patients. Patients who took simvastatin treatments were associated with lower odds of 30-day mortality (HR = 0.58, 95%CI: 0.43–0.78). Rosuvastatin treatments had a higher 30-day mortality risk (HR = 1.88, 95%CI: 1.29–2.75). Statin use was also associated with lower 30-day mortality among patients of different ages, sex, sequential organ failure assessment (SOFA), SAPS II, and SIRS.ConclusionPatients who were treated with simvastatin were associated with lower odds of 30-day mortality in SAE patients. Caution should be paid to statin use in SAE patients, particularly in patients treated with rosuvastatin or pravastatin.
Sex disparities in the risk of intracranial aneurysm rupture: a case–control study
Authors: Shen Dong , Cai Miaochun , Luo Yi , Li Zhihao , Zhang Peidong , Wang Yongkang , Fan Wenlong , Wu Hanqiu , Yu Yezhou , Gong Xijun , Mao Chen 
Published: December 2024

BackgroundThere are sex disparities in the risk of ruptured intracranial aneurysm (IA), but which sex-specific factors are related to ruptured IA remains inconclusive.MethodsData from electronic medical records from two tertiary hospitals, collected between January 2012 and December 2019, were analyzed for this study. All IAs were confirmed by computed tomographic angiography or digital subtraction angiography. Sex-specific factors associated with ruptured IA were analyzed using multivariable logistic models with a case–control study design. Age, aneurysm size, and aneurysm location subgroup analyses were conducted according to sex.ResultsIn total, 1883 patients [1,117 (59.32%) female, 766 (40.68%) male] with 2,423 IAs were included; 734 (38.98%) of patients had ruptured IAs. Compared with males, females had a higher risk of ruptured IA [odds ratio, 1.72 (95% confidence interval, 1.38–2.14)]. Age, aneurysm location, aneurysm size, multiple aneurysms, hypertension, history of intracerebral hemorrhage, and ischemic stroke were associated with risk of IA rupture in both sexes. In the subgroups based on the covariates used in this study, we only identified statistically significant interaction between sex and age. Although ruptured IAs were most common in males and females aged 50–59 and 60–69 years, respectively, risk of IA rupture peaked at ages 30 and 30–50 years in females and males, respectively, and decreased with age in both sexes.ConclusionFemales have an overall greater IA incidence and higher risk of IA rupture than males. Young age is one sex-specific risk factor associated with ruptured IA which could related to potential influence of hypertension, which might suggest more attention of IA rupture prevention in younger female.
Unveiling DENND2D as a Novel Prognostic Biomarker for Prostate Cancer Recurrence: From Gene to Prognosis
Authors: Chang Chi-Fen , Chen Lih-Chyang , Chen Yei-Tsung , Huang Chao-Yuan , Yu Chia-Cheng , Lin Victor C. , Lu Te-Ling , Huang Shu-Pin , Bao Bo-Ying 
Published: December 2024

Background: Prostate cancer is a major global health burden, with biochemical recurrence (BCR) following radical prostatectomy affecting 20–40% of patients and posing significant challenges to prognosis and treatment. Emerging evidence suggests a critical role for differentially expressed in normal and neoplastic cell (DENN) domain-containing genes in oncogenesis; however, their implications in prostate cancer and BCR risk remain underexplored. Methods: This study systematically evaluated 151 single-nucleotide polymorphisms in DENN domain-containing genes in 458 patients with prostate cancer and BCR, followed by validation in an independent cohort of 185 patients. Results: Multivariate Cox regression analyses identified DENND2D rs610261 G>A as significantly associated with improved BCR-free survival in both cohorts (adjusted hazard ratio = 0.39, 95% confidence interval = 0.23–0.66, p = 0.001). Functional analysis revealed rs610261’s regulatory potential, with the protective A allele correlating with increased DENND2D expression in various human tissues. Compared to normal prostate tissues, DENND2D expression was reduced in prostate cancer, with higher expression being linked to favorable patient prognosis (p = 0.03). Gene set enrichment analysis revealed an association between DENND2D expression and the negative regulation of MYC target genes, including MAD2L1, ERH, and CLNS1A, which are overexpressed in prostate cancer and associated with poor survival. Furthermore, the elevated DENND2D expression promotes immune infiltration in prostate cancer, supporting its role in immune modulation. Conclusions: DENND2D is a prognostic biomarker for BCR in prostate cancer and offers new avenues for personalized treatment strategies.
Effect of Lactic Acid Bacteria and Propionic Acid on Fermentation Characteristics, Chemical Composition, and Aerobic Stability of High-Moisture Corn Grain Silage
Authors: Bao Jinze , Wang Lei , Yu Zhu 
Published: December 2024

This investigation aimed to assess the effect of additives on the aerobic stability, fermentation profile, and chemical composition of high-moisture corn grain silage. The corn grain was milled and divided this into four distinct treatment groups: Lentilactobacillus buchneri, propionic acid, Lactiplantibacillus plantarum, and no additive (control). The capacity of the silos was 1 L and density was 1000 kg/m3. Each group had three replicates and was fermented for 45 d. At silo opening, one part of silage was used for fermentation parameters, chemical composition, and in vitro dry matter digestibility analysis; another part was used for aerobic stability determination. Compared with the control, all additives increased lactic acid and dry matter concentrations (p < 0.001) and decreased neutral detergent fiber level (p < 0.001). In comparison with the control, the application of Lentilactobacillus buchneri and propionic acid improved silage aerobic stability, showed by lower pH level and yeast and mold populations after exposure to air. The findings offer theoretical groundwork and technological backing for the use of high-moisture corn grain silage.
Sequential Defense Strategies: From Ant Recruitment to Leaf Toughness
Authors: dos Santos Danilo F. B. , Calixto Eduardo S. , Torezan-Silingardi Helena M. , Del-Claro Kleber 
Published: December 2024

Plants express many types of defenses in response to herbivory damage. These defenses can be displayed as a sequence or they can overlap, increasing efficiency in protection. However, leaf defense shifts during leaf development, including extrafloral nectaries (EFNs), are neglected in natural tropical systems. To address this gap, our study evaluates the shifts in defense strategies of Eriotheca gracilipes, focusing on extrafloral nectaries and leaf toughness across leaf development stages. We also simulate herbivory by cutting the leaves to address the role of visiting ants against herbivores. We observed that E. gracilipes exhibits a defense turnover, shifting from indirect defenses (e.g., EFNs) in young leaves to physical defenses in adult leaves. Simulated herbivory led to heightened ant visitation, which correlated with decreased herbivory rates, indicating that ant recruitment acts as an effective deterrent. We observed a peak of EFN activity in young leaves, increased foliar toughness in adult leaves, and reduced herbivory on ant-patrolled young leaves. Additionally, E. gracilipes demonstrated tolerance to up to 10% foliar loss with no significant impact on leaf asymmetry, although 50% foliar loss increased asymmetry in newly flushed leaves. These results highlight E. gracilipes’ adaptive flexibility by attracting protective ants when vulnerable and enhancing structural defenses as leaves develops, E. gracilipes minimizes herbivory impact. This study provides valuable insight into the adaptive roles of EFNs and tolerance in E. gracilipes, contributing to a broader understanding of plant defense strategies.
Fluctuation Induced Force in the Nagle–Kardar Model in Ensemble with Conserved Magnetization
Authors: Dantchev Daniel , Tonchev Nicholay S. , Rudnick Joseph 
Published: December 2024

For finite systems the thermodynamic potentials are not equivalent. Thus, in any of them the fluctuations induce different forces: Casimir force (CF) in the grand canonical ensemble (GCE) and Helmholtz force (HF) in the canonical (CE) one with fixed magnetization. Here, we consider the HF within the Nagle–Kardar model with periodic boundary conditions. The model represents a one-dimensional Ising chain with both nearest nearest-neighbor short-ranged and long-ranged interactions present in it. The nearest-neighbor interactions of strength Js could be either ferromagnetic (Js>0), or antiferromagnetic (Js<0). The long-ranged equivalent-neighbor ferromagnetic interactions are of strength Jl/N>0. In the thermodynamic limit the model exhibits in the (Ks=βJs, Kl=βJl) plane a second-order phase transition line 2Kl=exp−2Ks, with Ks>−ln(3)/4, which ends at a tricritical point (Kl=3/2, Ks=−ln(3)/4). The obtained results demonstrate that the temperature behavior of the HF differs essentially from the one of the CF. Furthermore, we show that the CE and GCE are not equivalent, even in the thermodynamic limit. Finally, in the {Ks,Kl,m} phase space we determine the regions of stable states of the system.
Penggunaan Berbagai Macam Biopestisida Pada Tindakan Preventif Dan Kuratif Terhadap Ulat Daun (Plutella xylostella) Pada Tanaman Sawi Pakcoy (Brassica rapa subsp chinensis)
Authors: P Lita Hardyati , Hamyana Hamyana , Pratiwi Arum 
Published: December 2024

Tanaman sawi pakcoy merupakan salah satu tanaman yang banyak dibudidayakan di Desa Wonorejo, Lawang. Plutella xylostella adalah salah satu hama utama tanaman ini. Larva merusak tanaman saat umur 2 minggu sampai 4 minggu, dengan memakan permukaan bawah daun tanaman sampai pada kerusakan berat sehingga tanaman tidak dapat tumbuh optimal ataupun dijual penelitian untuk mengetahui pengaruh penggunaan berbagai biopestisida pada tindakan preventif dan kuratif terhadap P.xylostella telah dilakukan dari bulan april samapi juni 2019. Penelitian menggunakan Rancangan Acak Kelompok faktorial dengan 2 faktor perlakuan. Faktor pertama adalah berbagai bipestisida P1= umbi gadung, P2= daun mimba, P3= daun pepaya, P4= daun sirsak. Faktor kedua adalah sisem tindakan T1= tindakan preventif dan T2= tindakan kuratif. Masing-masing dengan 5 kali ulangan. Parameter pada tindakan preventif adalah tinggi tanaman, jumlah daun, jumlah daun terserang , kemunculan hama, bobot basah per perlakuan dan bobot basah per satuan tanaman. Parameter pada tindakan kuratif adalah tinggi tanaman, jumlah daun, jumlah daun rusak, perkembangan hama, bobot basah per perlakuan dan bobot basah per satuan tanaman. Hasil penelitian menunjukkan penggunaan pestisida nabati umbi gadung dengan dosis optimum 15ml/liter berpengaruh terhadap kemunculan ulat daun pada tindakan preventif dan perkembangan hama pada tindakan kuratif. Dari masing-masing sistem tindakan berpengaruh terhadap produksi tanaman sawi pakcoy. Penggunaan pestisida nabati umbi gadung dosis optimum 15ml/liter pada tindakan preventif memberikan pengaruh terbaik.

Kata kunci— Biopestisida, Kuratif, Pakcoy, Plutella xylostella, Preventif
Uji Kemampuan Asap Cair secara in Vitro dan in Vivo Untuk Penyakit Antraknosa (Colletotrichum capsici) Pada Tanaman Cabai (Capsicum annum L)
Authors: Zuanif Vaya , Despita Rika 
Published: December 2024

Cabai mempunyai nilai ekonomis tinggi di Indonesia dan termasuk komoditas startegis. Penyakit antraknosa adalah salah satu penyakit penting pada tanaman cabai. Pengendalian penyakit antraknosa pada tanaman cabai menggunakan asap cair belum pernah dilakukan sehingga penelitian ini perlu untuk dilakukan. Tujuan penelitian ini adalah untuk mengetahui kemampuan asap cair dalam mengendalikan penyakit antraknosa pada tanaman cabai yang disebabkan oleh cendawan Colletotrichum capsici. Kajian dilakukan secara in vitro dan perlakuan yang sama dilakukan juga secara in vivo. Kajian in vitro dilakukan di Laboratorium Proteksi Tanaman dan kajian in vivo dilakukan di lahan BBPP Ketindan dimulai bulan Maret sampai Juni 2018. Metode kajian untuk in vitro yaitu Rancangan Acak Lengkap (RAL) dan metode kajian untuk in vivo yaitu Rancangan Acak Kelompok (RAK). Perlakuan terdiri dari B0K0:tanpa asap cair, B1K1:asap cair tempurung kelapa konsentrasi 1%, B1K3: asap cair tempurung kelapa konsentrasi 3%, B1K5: asap cair tempurung kelapa konsentrasi 5%, B1K7: asap cair tempurung kelapa konsentrasi 7%, B2K1: asap cair sekam konsentrasi 1%, B2K3: asap cair sekam konsentrasi 3%, B2K5: asap cair sekam konsentrasi 5%, B2K7: asap cair sekam konsentrasi 7%. Masing-masing perlakuan diulang sebanyak 4 kali sehingga diperoleh 36 satuan percobaan. Parameter yang diamati adalah diameter koloni cendawan dan persentase penghambatan asap cair. Hasil pengamatan in vitro menunjukkan bahwa aplikasi asap cair 3%, 5% dan 7% mampu menghambat pertumbuhan cendawan Colletotrichum capsici sebanyak 100%. Aplikasi asap cair dari tempurung kelapa secara in vivo (lapangan) dengan konsentrasi 7% mampu menghambat pertumbuhan cendawan Colletotrichum capsici dan aplikasi asap cair konsentrasi 1% mampu menghambat pertumbuhan cendawan Colletotrichum capsici sampai hari ke 4 setelah penyemprotan dengan arti lain penyemprotan perlu dilakukan setiap 4 hari sekali.

Kata kunci—asap cair tempurung kelapa, asap cair sekam, antraknosa, cabai
Evaluasi Penerapan Biosekuriti di Peternakan Ayam Joper Di Jawa Timur
Authors: Utami Kartika Budi , Samudra Ferdianto Budi 
Published: December 2024

ABSTRAK
Penerapan biosekuriti merupakan salah satu upaya memenuhi kesejahteraan ternak untuk mencegah terjadinya penularan penyakit zoonosis dari kegiatan beternak. Tujuan penelitian yaitu mengevaluasi penerapan biosekuriti di peternakan ayam joper skala usaha 500 ekor di Jawa Timur. Empat lokasi ditetapkan secara random sampling yaitu di Kabupaten Pasuruan, Kota pasuruan, Kota Batu dan Kabupaten Bojonegoro. Sebanyak 46 responden ditentukan secara purposive sampling. Evaluasi tindakan biosekuriti meliputi desinfeksi, disposal, sanitasi dan vaksinasi dilakukan melalui wawancara, observasi dan kuesioner, sedangkan identifikasi penyakit ayam menggunakan metode surveilans. Hasil evaluasi menunjukkan bahwa praktik biosekuriti di peternak wilayah Jawa Timur pada tindakan desinfeksi dan disposal termasuk kategori buruk (skor = 0), tindakan sanitasi termasuk kategori baik (skor = 2) dan tindakan vaksinasi termasuk kategori cukup baik (skor = 1). Penyakit yang diderita ayam yaitu penyakit viral dan penyakit bakteri. Penelitian ini menyarankan bahwa peternak perlu mendapatkan pendampingan tentang biosekuriti.
Kata kunci— biosekuriti, ayam joper, unggas lokal, kesejahteraan hewan
ABSTRACT
The application of biosecurity is one of the efforts to meet livestock welfare to prevent the transmission of zoonotic diseases from livestock activities. The purpose of the study was to evaluate the application of biosecurity in a Joper chicken farm in East Java. Four locations were determined by random sampling: Pasuruan Regency, Pasuruan City, Batu City, and Bojonegoro Regency. A total of 46 respondents were determined by purposive sampling. Evaluation of biosecurity measures including disinfection, disposal, sanitation, and vaccination was carried out through interviews, observations, and questionnaires, while the identification of chicken diseases used surveillance methods. The evaluation results show that the practice of biosecurity in East Java farmers in terms of disinfection and disposal is in a bad category (score = 0), sanitation measures are in a good category (score = 2) and vaccination measures are in the fairly good category (score = 1). Diseases suffered by chickens are viral diseases and bacterial diseases. This study suggests that farmers need to get assistance with biosecurity.
Keywords— biosecurity, joper chicken, local poultry, animal welfare
FEASIBILITY ANALYSIS OF EDAMAME FARMING BUSINESS CASE STUDY OF PWMP ZAAR IN BANJARBARU, SOUTH KALIMANTAN
Authors: Wahyudi Soleh , Wahid Abdul 
Published: December 2024

ABSTRAK
Seiring kesadaran masyarakat akan makanan sehat permintaan kedelai Edamame di Kalimantan Selatan semakin meningkat namun sebagian besar dipasok dari wilayah Jawa. Tujuan penelitian ini adalah untuk memberikan gambaran analisa usaha dan kelayakan usaha tani edamame studi kasus PWMP ZAAR SMKPPN Banjarbaru Kalimantan Selatan. Metode penelitian yang digunakan adalah deskriptif dengan pendekatan studi kasus. Pengambilan data primer secara wawancara mendalam terhadap responden dan data sekunder diambil dari hasil catatan usaha dan studi literatur. Analisis yang digunakan dalam penelitian ini adalah analisis biaya, penerimaan, keuntungan, Revenue Cost Ratio ( R/C) dan Benefit Cost Ratio (B/C). Berdasarkan hasil penelitian pada Kelompok PWMP ZAAR dapat disimpulkan bahwa usahatani edamame menguntungkan dan layak untuk diusahakan. Dengan luas usaha 0,45 ha dengan periode waktu 3 bulan memerlukan total biaya sebesar Rp 13.616.604,- total penerimaan sebesar Rp. 28.980.000,- dan keuntungan sebesar Rp.15.363.396,- dengan nilai R/C 2,13 dan B/C 1,13.
Kata Kunci: Edamame, Analisa Usaha, Kelayakan Usaha

ABSTRACT
Along with public awareness of healthy food, demand for Edamame soybeans in South Kalimantan is increasing, but most of this is supplied from the Java region. The purpose of this study is to provide an overview of business analysis and feasibility of Edamame farming, a case study of PWMP (The growth of Young Agricultural Enterpreneur) ZAAR Agriculture Vocational School of Banjarbaru, South Kalimantan. The research method used is descriptive with a case study approach. Primary data were collected by in-depth interviews with respondents and secondary data were taken from the results of business records and literature studies. The analysis used in this research is the analysis of costs, revenues, profits, Revenue Cost Ratio (R/C) and Benefit Cost Ratio (B/C). Based on the results of research in the PWMP ZAAR group, it can be concluded that Edamame farming is profitable and feasible to cultivate. With a business area of ​​0.45 ha with a period of 3 months requires a total cost of Rp. 13.616.604,- total revenue of Rp. 28,980,000, - and a profit of Rp.15.363.396,- with an R/C value of 2.13 and a B/C of 1.13.
Sikap Peternak Terhadap Pencegahan Penyakit Kembung Pada Kambing Di Kelompok Ternak Bina Asri
Authors: Febrianto Handhika Bayu Eka , Isyunani Isyunani , Rustandi Yudi 
Published: December 2024

Beberapa anggota kelompok Bina Asri Kecamatan Jabung masih ragu-ragu pada pencegahan penyakit kembung menggunakan ramuan herbal. Penelitian ini bertujuan mengetahui sikap peternak di Kelompok Ternak Bina Asri pada pencegahan penyakit kembung. Metode penelitian suvey dengan deskriptif kuantitatif. Populasi sekaligus total sampel penelitian yaitu anggota kelompok ternak sebanyak 25 responden. Instrumen yang digunakan adalah kuisioner dengan skala likert. Pengujian validitas dan reabilitas kuesioner dengan Cronbach Alpha. Analisis data menggunakan deskriptif kuantitatif. Setelah dilakukan penyuluhan terjadi perubahan sikap peternak, yaitu sikap peternak pada tingkat sikap menjadikan pola hidup dalam pencegahan penyakit kembung dengan rata-rata skor 87,32.

Some members of the Bina Asri group in Jabung District are still unsure about preventing bloating using herbal ingredients. This study aims to determine the attitude of farmers in the Bina Asri Livestock Group toward the prevention of bloating. Survey research method with quantitative descriptive. The population, as well as the total sample of the study, namely members of the livestock group, consisted of 25 respondents. The instrument used is a questionnaire with a Likert scale. They tested the validity and reliability of the questionnaire with Cronbach's Alpha. Data analysis used quantitative description. After counselling, there was a change in the attitude of the farmer, namely the attitude of the breeder at the attitude level, making a lifestyle in preventing bloating with an average score of 87.32.
ТРАДИЦІЇ І НОВАТОРСЬКІ ПІДХОДИ У СУЧАСНОМУ ВОКАЛЬНОМУ МИСТЕЦТВІ
Authors: Кдирова Інеш , Цапенко Неля , Плегуца Ольга 
Published: December 2024

Стаття присвячена уточненю актуальних тенденцій у вокальному мистецтві, що виникають завдяки взаємодії традиційних та новаторських технік, а також впливу інноваційних підходів на розвиток цього жанру. Мета – виявити сучасні тренди у виконавстві через переосмислення співаками вокальних традицій та індивідуальну творчу рефлексію, яка сприяє популяризації мистецьких здобутків і підсилює контакт із публікою. У методології дослідження використано культурно-історичний та компаративний підходи, а також дескриптивний аналіз естетичних і технічних рис вокального мистецтва в контексті постмодернізму, доповнений конкретними прикладами синтезу традиційних та інноваційних прийомів. У результаті дослідження виявлено характерні риси постмодерністського вокального виконавства, серед яких еклектизм, інтертекстуальність, деконструкція, а також розширення технічних можливостей за допомогою сучасних технологій. Наукова новизна полягає у вивченні взаємодії традиційних та інноваційних елементів у вокальному мистецтві та визначенні нових стильових підходів до інтерпретації музичних творів. Подальші дослідження передбачають аналіз впливу інноваційних методів на розвиток вокального мистецтва, дослідження взаємодії виконавців з аудиторією в умовах сучасної популяризації творчості через використання цифрових технологій для створення інтерактивних музичних проєктів.