bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Pathway-Specific Polygenic Risk Score Is Associated with Tau Pathology and Cognitive Decline
Authors: Sun Yuqing , Wang Meng , Zhao Yuxin , Hu Ke , Liu Yong , Liu Bing ,   Alzheimer’s Disease Neuroimaging Initiative
Published: December 2021

Background: Tauopathy is a primary neuropathological hallmark of Alzheimer’s disease with a strong relationship to cognitive impairment. In the brain, tau aggregation is associated with the regulation of tau kinases and the binding ability of tau to microtubules. Objective: To explore the potential for using specific polygenic risk scores (PRSs), combining the genetic influences involved in tau-protein kinases and the tau-protein binding pathway, as predictors of tau pathology and cognitive decline in non-demented individuals. Methods: We computed a pathway-specific PRS using summary statistics from previous large-scale genome-wide association studies of dementia. We examined whether PRS is related to tau uptake in positron emission tomography (PET), tau levels, and the rate of tau level changes in cerebrospinal fluid (CSF). We further assessed whether PRS is associated with memory impairment mediated by CSF tau levels. Results: A higher PRS was related to elevated CSF tau levels and tau-PET uptake at baseline, as well as greater rates of change in CSF tau levels. Moreover, PRS was associated with memory impairment, mediated by increased CSF tau levels. The association between PRS and tau pathology was significant when APOE was excluded, even among females. However, the effect of PRS on cognitive decline appeared to be driven by the inclusion of APOE. Conclusion: The influence of genetic risk in a specific tau-related biological pathway may make an individual more susceptible to tau pathology, resulting in cognitive dysfunction in an early preclinical phase of the disease.
Effects of Memantine and High Dose Vitamin D on Gait in Male APP/PS1 Alzheimer’s Disease Mice Following Vitamin D Deprivation
Authors: Broberg Dana N. , Wong Dickson , Bellyou Miranda , Montero-Odasso Manuel , Beauchet Olivier , Annweiler Cedric , Bartha Robert 
Published: December 2021

Background: Altered gait is a frequent feature of Alzheimer’s disease (AD), as is vitamin D deficiency. Treatment with memantine and vitamin D can protect cortical axons from exposure to amyloid-β and glutamate toxicity, suggesting this combination may mitigate altered gait in AD. Objective: Investigate the effects of vitamin D deprivation and subsequent treatment with memantine and vitamin D enrichment on gait performance in APPswe/PS1dE9 mice. Methods: Male APPswe/PS1dE9 mice were split into four groups ( n = 14 each) at 2.5 months of age. A control group was fed a standard diet throughout while the other three groups started a vitamin D-deficient diet at month 6. One group remained on this deficient diet for the rest of the study. At month 9, the other two groups began treatment with either memantine alone or memantine combined with 10 IU/g of vitamin D. Gait was assessed using CatWalk at months 6, 9, 12, and 15. Results: Vitamin D deprivation led to a 13% increase in hind stride width by month 15 ( p < 0.001). Examination of the treatment groups at month 15 revealed that mice treated with memantine alone still showed an increase in hind stride width compared to controls ( p < 0.01), while mice treated with memantine and vitamin D did not ( p = 0.21). Conclusion: Vitamin D deprivation led to impaired postural control in the APPswe/PS1dE9 model. Treatment with memantine and vitamin D, but not memantine alone, prevented this impairment. Future work should explore the potential for treatments incorporating vitamin D supplementation to improve gait in people with AD.
lncRNA MIR600HG Knockdown Alleviates Cognitive Impairment in Alzheimer’s Disease Through NEDD4L Mediated PINK1 Degradation
Authors: Liu Qingqing , Ling Zaisheng , Zhang Jinpeng , Yu Hongli , Wang Ye , Xue Yang , Wang Chunyan , Zhao Jiwei , Cao Jingwei , Duan Shurong , Zhao Jingkun 
Published: December 2021

Background: Growing evidence has demonstrated that long non-coding RNAs (lncRNAs) play a critical role in Alzheimer’s disease (AD), which is characterized by sustained mitochondrial dysfunction, inevitable memory loss, and cognitive decline. However, the potential function of lncRNAs MIR600 Host Gene (MIR600HG) in AD remains unanswered. Objective: Our study aimed to investigate the role of MIR600HG and its related molecular mechanism in AD. Methods: The expression of MIR600HG was examined by qRT-PCR. The MIR600HG interacting proteins were identified by RNA pull-down assay and mass spectrometry and verified by RNA immunoprecipitation. Immunofluorescence staining was applied to examine the colocalization of PINK1 and NEDD4L. The PINK1 level and the activation of autophagy were detected by immunoblotting. Morris water maze test was performed to evaluate cognitive decline in AD mice model. Results: MIR600HG expression was elevated during aging in two different types of AD transgenic mouse models. Next, we found that increased MIR600HG directly interact with NEDD4L, which promoted PINK1 ubiquitination and degradation, and as well as autophagy activation. Additionally, MIR600HG promoted Aβ production and suppressed Cytochrome C Oxidase activity. Administration of AAV-shMIR600HG restored the Cytochrome C Oxidase activity and inhibited Aβ production. Furthermore, PINK1 overexpression or MIR600HG knockdown significantly ameliorated the cognitive impairment in APP/PS1 mice. PINK1 depletion recovered the spatial memory defect in the AAV-shMIR600HG injected APP/PS1 mice. Conclusion: MIR600HG was increased in AD and promoted AD pathogenesis. Targeting MIR600HG significantly improved cognitive function in AD mice, which could pave the way for exciting new avenues in AD therapeutic strategy research.
Difference in Amyloid Load Between Single Memory Domain and Multidomain Subjective Cognitive Decline: A Study from the SILCODE
Authors: Wang Xiaoqi , Bi Qiuhui , Lu Jie , Chan Piu , Hu Xiaochen , Su Li , Jessen Frank , Lin Hua , Han Chunlei , Shu Ni , Liu Hesheng , Han Ying 
Published: December 2021

Background: Subjective cognitive decline (SCD), an at-risk condition of Alzheimer’s disease (AD), can involve various cognitive domains, such as memory, language, planning, and attention. Objective: We aim to explore the difference in amyloid load between the single memory domain SCD (sd-SCD) and the multidomain SCD (md-SCD) and assess the relationship of amyloid pathology with quantitative SCD scores and objective cognition. Methods: A total of 63 SCD participants from the SILCODE study underwent the clinical evaluation, neuropsychological assessment, and 18F-florbetapir PET scan. Global amyloid standard uptake value ratio (SUVr) was calculated. Additionally, regional amyloid SUVr was quantified in 12 brain regions of interests. A nonparametric rank ANCOVA was used to compare the global and regional amyloid SUVr between the md-SCD ( n = 34) and sd-SCD ( n = 29) groups. A multiple linear regression analysis was conducted to test the relationship of amyloid SUVr with quantitative SCD scores and objective cognition. Results: Compared with individuals with sd-SCD, individuals with md-SCD had increased global amyloid SUVr ( F = 5.033, p = 0.029) and regional amyloid SUVr in the left middle temporal gyrus ( F = 12.309, p = 0.001; Bonferroni corrected), after controlling for the effects of age, sex, and education. When pooling all SCD participants together, the increased global amyloid SUVr was related with higher SCD-plus sum scores and lower Auditory Verbal Learning Test-delayed recall scores. Conclusion: According to our findings, individuals with md-SCD showed higher amyloid accumulation than individuals with sd-SCD, suggesting that md-SCD may experience a more advanced stage of SCD. Additionally, increased global amyloid load was predictive of a poorer episodic memory function in SCD individuals.
Design of feasibility analysis platform for college physical education based on mobile social network
Authors: Han Yingchao , Liao Jianlu 
Published: December 2021

In order to promote the development of sports distance network education, a college sports teaching feasibility analysis platform based on mobile social network is designed. The key technologies such as Ajax, database and XML, Java Web containers applied to mobile social networks provide a technical basis for the platform design of this paper. Design the feasibility analysis platform framework using MVC mode, three platform functional modules were designed. Among it, the member function module is responsible for the registration and modification of the platform personal information of members; The feasibility analysis interactive discussion module is based on the cloud database storage and analysis platform user discussion records; The feasibility evaluation module of mobile social network is based on mobile social network, builds the hierarchical model of feasibility analysis and completes the design of feasibility analysis of distance teaching in universities. Experimental performance tested the platform, with an average response time of 2.3 ms and an analysis time of 18 ms. The feasibility analysis results of the platform have high reliability and effectiveness to meet the practical application requirements.
Intelligent fault diagnosis using image representation of multi-domain features
Authors: Zhang Yulong , Zhang Chaofei , Tan Jian , Lim Frank , Duan Menglan 
Published: December 2021

Deep learning (DL) algorithms, especially the convolutional neural network (CNN), have been proven as a newly developed tool in machinery intelligent diagnosis. However, the current CNN-based fault diagnosis studies usually consider features or images extracted from a single domain as model input. This single domain information may not reflect fault patterns comprehensively, leading to low modeling accuracy and inaccurate diagnostic results. To overcome this limitation, this paper proposes a new CNN-based fault diagnosis approach using image representation considering multi-domain features of vibration signals. First, multi-domain features of vibration signals are extracted. These extracted features are then used to construct a n × n matrix, and subsequently to form images by RGB color transformations. This image transformation technique allows for capturing complementary and rich diagnostic information from multiple domains. At last, these images associated with different mechanical defects are fed into a CNN model that is improved based on the classic LeNet-5 CNN architecture for fault diagnosis and identification. Comparative experiments with the traditional feature extraction methods as well as state-of-the-art CNN-based methods are also investigated. Experimental studies on rolling bearings validate the effectiveness and superiorities of the proposed approach.
Extended Disease Control with Unconventional Cabozantinib Dose Increase in Metastatic Renal Cell Carcinoma
Authors: Sharma Akanksha , Elias Roy , Christie Alana , Williams Noelle S. , Pedrosa Ivan , Bjarnason Georg A. , Brugarolas James 
Published: December 2021

BACKGROUND: Cabozantinib is among the most potent tyrosine kinase inhibitors (TKIs) FDA-approved for metastatic renal cell carcinoma (mRCC). Effective treatments after progression on cabozantinib salvage therapy are limited. Dose escalation for other TKIs has been shown to afford added disease control. OBJECTIVE: We sought to evaluate whether dose escalation of cabozantinib (Cabometyx®) from conventional doses in select patients with limited treatment options offered additional disease control. We asked how cabozantinib dose increases may affect circulating drug levels. METHODS: We identified patients with mRCC at the University of Texas Southwestern Medical Center who were treated with cabozantinib dose escalation to 80 mg after progressing on conventional cabozantinib 60 mg. We then queried leading kidney cancer investigators across the world to identify additional patients. Finally, we reviewed pharmacokinetic (PK) data to assess how higher doses impacted circulating levels by comparison to other formulations (Cometriq® capsules). RESULTS: We report six patients treated at two different institutions with cabozantinib-responsive disease and good tolerability, where cabozantinib was dose escalated (typically to 80 mg, but as high as 120 mg) after progression on 60 mg, a strategy that resulted in added disease control (median duration, 14 months; 95% Confidence Interval [CI]: 8 –Not Estimable[NE]). Four patients (66.7%) had disease control lasting at least 1 year. No grade III/IV adverse events were identified in this small, select, cohort. A comparison of PK data to FDA-approved cabozantinib 140 mg capsules suggests that cabozantinib 80 mg tablets results in comparable exposures. CONCLUSIONS: mRCC patients with cabozantinib responsive disease and reasonable tolerability may benefit from dose escalation at progression.
EFEKTIVITAS PENGOLAHAN LIMBAH CAIR DOMESTIK DENGAN MENGGUNAKAN MEDIA TUTUP GALON BEKAS
Authors: Natsir Muh. Fajaruddin , Amaludin Amaludin , Liani Astisa Anggi , Fahsa Anzakiyah Dwi , Marlina Desi 
Published: December 2021

Limbah cair merupakan sumber pencemaran air yang sangat potensial karena mengandung senyawa yang cukup tinggi, dan senyawa kimia lain serta mikroorganisme patogen yang berbahaya bagi kesehatan sehingga perlu dilakukan pengolahan terlebih dahulu sebelum di buang ke badan air. Penelitian ini bertujuan untuk mengetahui efektivitas pengolahan limbah cair domestik dengan menggunakan media tutup galon bekas pada biofilter dalam mereduksi parameter BOD dan TSS limbah cair domestik. Penelitian ini bersifat quasi eksperimen dengan rancangan Pretest-Postest Design. Penelitian dimulai dengan kajian literatur, pembuatan biofilter, penyiapan media, dan penelitian inti yaitu pengujian biofilter. Hasil penelitian menunjukkan bahwa setelah dilakukan dengan menggunakan biofilter media tutup galon didapatkan penurunan untuk parameter BOD dari 186,75 mg/L menjadi 6,31 mg/L dengan efisiensi sebesar 97 %. Sedangkan untuk parameter TSS dari 81,65 mg/L menjadi 3 mg/L dengan efisiensi penurunan sebesar 94 %. Pengolahan limbah cair dengan menggunakan biofilter media tutup galon bekas terbukti efektif menurunkan parameter BOD, dan TSS sesuai baku mutu berdasarkan Peraturan Menteri Lingkungan Hidup dan Kehutanan RI Nomor 68 Tahun 2016 Tentang Baku Mutu Air Limbah Domestik.Kata kunci :Biofilter, Tutup Galon Bekas, Limbah Cair
Adaptive Approach To Creating Conditions For Practical Self-Realization Of Future Teacher-Programmers
Authors: Парафіянович Тамара , Бущик Єлизавета , Новоселов Микита 
Published: December 2021

Summary. The article substantiates the relevance of an adaptive approach to creating conditions in the educational process for the practical self-realization of students, considered as the implementation of the educational and research abilities of future teacher-programmers, and the formation of professional competencies. In the modern high-tech world, when digital technologies become the environment for the existence of future specialists with new opportunities for their interactions and the desire to solve problems through IT technologies, one of the trends in the development of the education system is to improve its quality, «... includes adaptive processes». Adaptive processes in the design of educational programs are based on the formation of a digital educational space, the availability of online training, the possibility of organizing mixed training, and building individual educational activities. Adaptive approaches are considered as personification of the practical-oriented component of educational activity, development of value orientations, attitudes, as a person-oriented interaction of a teacher-student and a weak impact, which under certain conditions can give a strong resonance. Adaptive approaches are presented as a system of flexible management methods that contribute to the practical realization of the interests, abilities and educational needs of students aimed at forming the basic professional competencies of future teacher-programmers. Adaptive approaches in learning management are considered as the personalization of distance activities, as the process of managing the personal and professional development of students; a process that contributes to the desired learning outcomes; the process of using management impacts. The adaptive interaction between the teacher and the student includes pedagogical support, allows you to focus on the abilities and professional preferences of future teacher-programmers, equalize their opportunities for self-realization, self-organization, self-development and personalize the accumulation of universal and professional competencies. The article notes that the widespread use of adaptive approaches has led to a shift in emphasis in education to the achievement of a practical result in the formation of professional competencies, which are not only the result of training, but also a resource for further quality education, training specialists for independent professional activities, the ability to quickly adapt to new socio-professional challenges and a willingness to study during life.
Key words: adaptive approaches, adaptive interaction, digitalization, practical self-realization, training results, personalization, professional competencies of future teacher-programmers.
Педагогічна діяльність та особистість майбутнього інженера-педагога в контексті інноваційного розвитку освіти
Authors: Бобрикова Юлія 
Published: December 2021

Анотація. У статті проаналізовано педагогічну діяльність майбутнього інженера-педагога в контексті інноваційного розвитку і обґрунтовано вплив використання інноваційних методів та технологій на розвиток педагогічної майстерності майбутнього інженера-педагога - учасника інноваційних процесів, покращення якісних показників навчальних досягнень та необхідність використання інноваційних методів та технологій для майбутнього фахівця.
Розглянуто актуальність використання інноваційних методів та технологій в процесі професійної підготовки майбутнього інженера-педагога, які полягають у тому, щоб навчити майбутнього фахівця самостійно здобувати знання та застосовувати їх для розв’язання нових пізнавальних і практичних завдань; сприяти розвитку комунікативних здібностей; розширити коло спілкування; прищепити уміння користуватися дослідницькими прийомами: збирати та аналізувати інформацію, висувати гіпотези, робити висновки.
Розглянуто методи інтерактивного навчання та їх організаційно-методичні форми, які є найбільш оптимальними щодо застосування на певному виді занять під час підготовки фахівців.
З’ясовано роль інноваційних методів та технологій у формуванні готовності майбутніх фахівців до професійної діяльності, їх мислення та поведінки.
Схарактеризовано комплекс професійно значущих якостей майбутніх інженерів-педагогів необхідних для успішної професійної діяльності та особливу увагу приділено сучасним інформаційним технологіям, їх можливостям для вдосконалення професійних умінь.
Отримано висновки та вказано перспективи подальших досліджень в межах заданого напряму .
Ключові слова: інноваційні технології, інноваційний підхід, освіта, студент, викладач, інженер-педагог.
Groups \(S_n \times S_m\) in construction of flag-transitive block designs
Authors:   Faculty of science, University of Split, 21 000 Split, Croatia, Braić Snježana , Mandić Joško ,   Faculty of science, University of Split, 21 000 Split, Croatia, Šubašić Aljoša ,   Faculty of science, University of Split, 21 000 Split, Croatia, Vojković Tanja ,   Faculty of science, University of Split, 21 000 Split, Croatia, Vučičić Tanja ,   Faculty of science, University of Split, 21 000 Split, Croatia
Published: December 2021

In this paper, we observe the possibility that the group \(S_{n}\times S_{m}\) acts	as a flag-transitive automorphism group of a block design with point set \(\{1,\ldots ,n\}\times \{1,\ldots ,m\},4\leq n\leq m\leq 70\). We prove the	equivalence of that problem to the existence of an appropriately defined	smaller flag-transitive incidence structure. By developing and applying	several algorithms for the construction of the latter structure, we manage	to solve the existence problem for the desired designs with \(nm\) points in	the given range. In the vast majority of the cases with confirmed existence,	we obtain all possible structures up to isomorphism.
Conhecimentos estatísticos: percepções de educandos do Ensino Médio, em uma escola pública, no município de Caxias, Maranhão
Authors: Oliveira Francinete Sousa de , Ferreira Maria Fernanda Ribeiro , Lustosa Guilherme Santana 
Published: December 2021

A presente pesquisa, é o resultado de um trabalho desenvolvido com alunos do 3° do Ensino Médio, que teve como objetivo o de avaliar a percepção dos educandos sobre conhecimentos estatísticos, assim como descobrir se a realização da atividade contribuiu para aprendizagem desses conteúdos. A ideia surgiu mediante a detecção da carência de práticas com esse propósito. O instrumento utilizado para analisar as contribuições da atividade, na identificação da percepção e aprendizagem de Estatística, foi um questionário e as informações obtidas foram organizadas em gráficos, para que se realizasse uma análise quanti qualitativa das informações, amparadas pela análise de conteúdo. A referida atividade, conseguiu evidenciar que uma parcela do público pesquisado, não conhecia a Estatística e desconhece a sua aplicabilidade. Outra situação também identificada, é que os alunos não veem a Estatística, reduzida apenas a conhecimentos matemáticos e que está associada, as mais diversas áreas do conhecimento, além de ser representativa a contribuição da atividade, quanto a aprendizagem sobre os conhecimentos estatísticos. A pesquisa pode proporcionar informações que podem ser utilizadas, por profissionais do ensino, e assim oferecer possíveis ações que possam atenuar as dificuldades presentes, quanto a aprendizagem de Estatística. Assim este trabalho oferece caminhos de como realizar intervenções que envolvam conhecimentos estatísticos em diversas áreas do conhecimento, isto porque a metodologia do Arco de Maguerez é facilmente adaptada a todos os campos do saber, o que sem dúvidas pode contribuir significativamente na aprendizagem.