bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adsorption of nitrate and nitrite from aqueous solution by magnetic Mg/Fe hydrotalcite
Authors: Chen Jing , Wei Yawei , Ji Haoyu , Guo Pengliang , Wan Dongjin , Li Bo , Sun Xuzhuo 
Published: June 2021

Abstract
In this study, magnetic Mg/Fe hydrotalcite calcined material (M-CHT) was synthesized through the co-precipitation and calcination method, and was used to effectively remove nitrate and nitrite from water. M-CHT can restore its original layered structure after the adsorption of nitrate or nitrite, and can be easily separated by an applied magnetic field. The first-order and pseudo-second-order kinetic models (R2 ≥ 0.97) can better describe the adsorption kinetic process. The equilibrium isotherm showed that the Langmuir model provided a better fit to the experimental data than the Freundlich model for nitrates and nitrites. With temperature increased from 298 to 308 K, the maximum adsorption capacity obtained by the Langmuir model increased from 10.60 to 16.90 mg-N/g for nitrate and 7.89 to 14.28 mg-N/g for nitrite, respectively. The adverse effect of coexisting anions ranked in the order of ClO4− &gt; Cl− &gt; SO42− &gt; F− &gt; CO32− &gt; PO43−. The actual Fe2+/Fe3+ value of M-CHT (0.56) is nearly consistent with the theoretical value of 0.5, and the saturation magnetic strength value of M-CHT is 9.15 emu/g, greatly contributing to the solid–liquid separation. Overall, M-CHT with features of magnetic properties and satisfactory adsorption capacity exhibits great promise for application in wastewater purification.
Electrochemical degradation of chloramphenicol using Ti-based SnO2–Sb–Ni electrode
Authors: Li Dan , Zhang Libao , Gao Weichun , Meng Jing , Guan Yinyan , Liang Jiyan , Shen Xinjun 
Published: June 2021

Abstract
Antibiotic residues may be very harmful in aquatic environments, because of limited treatment efficiency of traditional treatment methods. An electrochemical system with a Ti-based SnO2–Sb–Ni anode was developed to degrade a typical antibiotic chloramphenicol (CAP) in water. The electrode was prepared using a sol–gel method. The performance of electrode materials, impact factors and dynamic characteristics were evaluated. The Ti-based SnO2–Sb–Ni electrode was compact and uniform as shown by characterization using SEM and XRD. The electrocatalytic oxidation of CAP was carried out in a single-chamber reactor by using a Ti-based SnO2–Sb–Ni electrode. For 100 mg L−1 CAP, the CAP removal ratio of 100% and the TOC removal ratio of 60% were obtained at the current density of 20 mA cm−2 and in a neutral electrolyte at 300 min. Kinetic investigation has shown that the electro-oxidation of CAP on a Ti-based SnO2–Sb–Ni electrode displayed a pseudo-first-order kinetic model. Free radical quenching experiments presented that the oxidation of CAP on Ti-based SnO2–Sb–Ni electrode resulted from the synergistic effect of direct oxidation and indirect oxidation (·OH and ·SO4−). Doping Ni on the Ti/SnO2–Sb electrode for CAP degradation was presented in this paper, showing its great application potential in the area of antibiotic and halogenated organic pollutant degradation.
Long Non-coding RNA AFAP1-AS1 Facilitates Prostate Cancer Progression by Regulating miR-15b/IGF1R Axis
Authors: Liu Bo , Jiang Hui-Yang , Yuan Tao , Zhou Wei-Dong , Xiang Zhen-Dong , Jiang Qi-Quan , Wu Deng-Long 
Published: June 2021

Background:
Prostate cancer (PCa) is a commonly diagnosed malignant cancer and is the second-
highest cause of cancer death in men worldwide. Enzalutamide is the second-generation inhibitor of androgen
receptor signaling and is the fundamental drug for the treatment of advanced PCa. However, the disease
will eventually progress to metastatic castration-resistant prostate cancer (CRPC) and aggressive neuroendocrine
prostate cancer (NEPC) because of androgen-deprivation therapy (ADT) resistance. The aim of the
study was to investigate the role of long non-coding RNA (lncRNA) AFAP1-AS1 in ADT resistance.

Methods:
Quantitative real-time PCR analysis (qPCR) was used to assess the expression of AFAP1-AS1 in
PCa cell lines and tissues. Cell proliferation and invasion were assessed after AFAP1-AS1 knockdown using
Cell Counting Kit (CCK)-8 and Transwell assay, respectively. A dual-luciferase reporter gene assay was carried
out to validate the regulatory relationship among AFAP1-AS1, microRNA (miR)-15b, and insulin-like
growth factor1 receptor (IGF1R).

Results:
AFAP1-AS1 level was markedly increased in castration-resistant C4-2 cells and NE-like cells (PC3,
DU145, and NCI-H660), compared with androgen-sensitive LNCaP cells. Enzalutamide treatment increased
the expression of AFAP1-AS1 in vitro and in vivo. Functionally, AFAP1-AS1 knockdown repressed tumor cell
proliferation and invasion. Mechanistically, AFAP1-AS1 functioned as an oncogene in PCa through binding to
miR-15b and destroying its tumor suppressor function. Finally, we identified that AFAP1-AS1 up-regulated
IGF1R expression by competitively binding to miR-15b to de-repress IGF1R.

Conclusion:
AFAP1-AS1 facilitates PCa progression by regulating miR-15b/IGF1R axis, indicating that
AFAP1-AS1 may serve as a diagnostic biomarker and therapeutic target for PCa.
Enhanced Solubility of Albendazole in Cyclodextrin Inclusion Complex: A Molecular Modeling Approach and Physicochemical Evaluation
Authors: de Melo Camila Gomes , da Costa Lucas Amadeu Gonzaga , Rabello Marcelo Montenegro , de Albuquerque Wanderley Sales Victor , Ferreira Aline Silva , da Silva Paulo César Dantas , Nishimura Rodolfo Hideki Vicente , da Silva Rosali Maria Ferreira , de Araújo Rolim Larissa , Neto Pedro José Rolim 
Published: June 2021

Background:Albendazole (ABZ) is the drug of choice for the treatment of a variety of human and veterinary parasites. However, it has low aqueous solubility and low bioavailability. Cyclodextrins (CD) are pharmaceutical excipients with the ability to modulate the solubilization property of hydrophobic molecules.Objective:The aim of the study was to analyze through in vitro and in silico studies (Autodock Vina software and CycloMolder platform) the formation of inclusion complexes between ABZ, β-cyclodextrin (β-CD) and its derivatives Methyl-β-cyclodextrin (M-β-CD) and Hydroxypropyl-β-cyclodextrin (HP-β-CD).Methods:The most stable inclusion complexes were produced by the kneading method and characterized by Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), X-Ray Diffraction (XRD), determination of the ABZ content and in vitro dissolution profile.Results:Molecular modeling revealed that inclusion complexes between HP-β-CD:ABZ (in the proportion 1:1 and 2:1) presented the lowest formation energy and the highest number of intermolecular interactions, showing that the use of more cyclodextrins does not generate gains in the stability of the complex. On the characterization tests, the complexes experimentally obtained by the kneading method demonstrated highly suggestive parameters, including ABZ in HP-β-CD in both molar proportions, suppression of bands in the infrared spectrum, displacement of the drug's melting temperature in DSC, crystallinity halos instead of the characteristic peaks of ABZ crystals in the XRD and a release of more than 80% of ABZ in less than 5 minutes, dissolution efficiency of up to 92%.Conclusion:In silico studies provided a rational selection of the appropriate complexes of cyclodextrin, enabling the elaboration of more targeted complexes, decreasing time and costs for elaboration of new formulations, thereby increasing the oral biodisponibility of ABZ.
A Natural Membrane Vesicle Exosome-based Sinomenine Delivery Platform for Hepatic Carcinoma Therapy
Authors: Wang Ying , Zhao Ling , Yuan Wanwen , Liang Leyi , Li Ming , Yu Xuesong , Wang Yan 
Published: June 2021

Background:
Recent evidence has been demonstrated that Sinomenine (SIN) exerts antitumor
activity in vitro. However, the clinical utility of SIN remains limited mainly because of its
poor bioavailability. Exosomes are nanoscale vesicles that play crucial roles in intracellular communications
through functionally active substances such as DNA and RNA. Exosomes have been utilized
as nanocarriers for targeted drug delivery of different anticancer drugs.

Methods:
The present study aimed to evaluate the effectiveness of combined Exosomes-SIN for
the treatment of hepatocellular carcinoma (HCC) in a rat model. To do so, we prepared a mixture
of SIN and exosomes (Exo-SIN) to improve the bioavailability of SIN to treat liver cancer. The in
vitro releasing profile of the Exo-SIN was examined.

Results:
We observed a continuous, slow release of SIN from Exo-SIN in simulated body fluid as
well as tumor microenvironment. In the cytotoxicity test, Exo-SIN exhibited a significantly
stronger inhibition in HepG2 cells compared to free SIN. The flow cytometry assessments showed
that Exo-SIN could suppress HepG2 cell migration in a Transwell assay and induce cell cycle arrest
and cellular apoptosis. Western blotting showed that survivin, a crucial protein for the survival
of living cells, was significantly downregulated after treatment with Exo-SIN.

Conclusion:
In conclusion, our data suggested that Exo-SIN could serve as a potential, effective delivery
platform for hepatic carcinoma therapy.
Solving the Gap Between HCV Detection and Treatment in Prison HCVRNA
Testing and Treatment in a Cohort of Newly Arrived Convicts in
Southern Italy
Authors: Izzo Carmine , Masarone Mario , Torre Pietro , Melara Giuseppe , De Matteis Giuseppe , De Luna Antonio , Pagano Antonio Maria , Persico Marcello 
Published: June 2021

Introduction:
HCV infection elimination is set to be carried out by 2030. To achieve
this goal, the WHO has set minor achievable short-term “mini-goals.” One of these is treating “difficult
to reach and treat populations,” such as prisoners. One of the biggest obstacles to achieving
this mini goal is the poor knowledge of the real HCV prevalence in such a population and the barriers
to its detection, treatment, and follow-up. Even if HCV testing in Italian prisons is feasible and
recommended, it is not however always carried out. To worsen the picture, the peculiar status of
conviction is correlated to difficulty in caring out the antiviral therapy due to loss in follow-up and
to the refusals by inmates.

Aims:
A point-of-care test-and-treat program was set up in a penitentiary in Southern Italy to reduce
the number of patients Lost To Follow-Up (LTFU) between detection and treatment. A secondary
aim was to evaluate the prevalence of HCV-infected patients in a cohort of newly arrived
inmates.

Methods:
This prospective-observational study was carried out from January 2020 to February
2020. We performed an HCV-RNA blood capillary quick test on all newly arrived inmates. As a
routine, the new inmates underwent clinical and laboratory assessments. To those who were detected
HCV-RNA positive, the shortest possible antiviral treatment was offered, according to genotype
and clinical features.

Results:
We observed 122 new inmates in the period between January and February of 2020. Overall,
62 (50.8%) subjects took HCV-RNA quick testing through blood sampling. Four (6.4%) subjects
were found to be HCV-RNA positive; 1 refused antiviral therapy, while 3 accepted, obtaining
100% SVR. None of the HCV-active inmates were lost to follow up between detection and treatment
proposal.

Conclusion:
The use of a high-speed test-and-treat protocol for HCV infection was demonstrated
to be effective in avoiding LTFU in HCV-positive new inmates in the period between detection
and treatment. We observed an apparent prevalence of HCV incident cases in newly arrived inmates
of 6.4%. Antiviral therapy was quickly provided and found to be effective and successful.
Effects of Telemedicine and mHealth on Systolic Blood Pressure Management in Stroke Patients: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Lv Meina , Wu Tingting , Jiang Shaojun , Chen Wenjun , Zhang Jinhua 
Published: June 2021

Background
Stroke is a common, harmful disease with high recurrence and mortality rates. Uncontrolled blood pressure is an important and changeable risk factor for stroke recurrence. Telemedicine and mobile health (mHealth) interventions may have the potential to facilitate the control of blood pressure among stroke survivors, but their effect has not been established.

Objective
This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to estimate the effects of telemedicine and mHealth interventions on the control of systolic blood pressure among stroke survivors.

Methods
The research literature published up to June 28, 2020, and consisting of RCTs related to telemedicine and mHealth interventions was searched in PubMed, EMBASE, Web of Science, and the Cochrane Library. The Cochrane risk of bias tool (RoB 2.0) was used to evaluate the quality of the studies. The Cochran Q test and I2 statistic were used to assess heterogeneity. Data were meta-analyzed using a random-effects model. Mean difference (MD) with 95% CI and 95% prediction interval (PI) were calculated.

Results
In total, 9 RCTs with a total sample size of 1583 stroke survivors met the inclusion criteria. Compared with the usual care, telemedicine and mHealth had a significantly greater impact on the control of systolic blood pressure (MD –5.49; 95% CI –7.87 to –3.10; P<.001; 95% PI –10.46 to –0.51). A subgroup analysis showed that the intervention mode of telephone plus SMS text messaging (MD –9.09; 95% CI –12.71 to –5.46; P<.001) or only telephone (MD –4.34; 95% CI –6.55 to –2.13; P<.001; 95% PI –7.24 to –1.45) had a greater impact on the control of systolic blood pressure than usual care. Among the stroke survivors with an intervention interval ≤1 week (MD –6.51; 95% CI –9.36 to –3.66; P<.001; 95% PI –12.91 to –0.10) or a baseline systolic blood pressure ≥140 mm Hg (MD –6.15; 95% CI –9.44 to –2.86; P<.001; 95% PI –13.55 to 1.26), the control of systolic blood pressure using telemedicine and mHealth was better than that of usual care.

Conclusions
In general, telemedicine and mHealth reduced the systolic blood pressure of stroke survivors by an average of 5.49 mm Hg compared with usual care. Telemedicine and mHealth are a relatively new intervention mode with potential applications for the control of systolic blood pressure among stroke survivors, especially those with hypertensive stroke.
An Environmental Scan of Virtual “Walk-In” Clinics in Canada: Comparative Study
Authors: Matthewman Spencer , Spencer Sarah , Lavergne M Ruth , McCracken Rita K , Hedden Lindsay 
Published: June 2021

Background
Canada has been slow to implement virtual care relative to other countries. However, in recent years, the availability of on-demand, “walk-in” virtual clinics has increased, with the COVID-19 pandemic contributing to the increased demand and provision of virtual care nationwide. Although virtual care facilitates access to physicians while maintaining physical distancing, there are concerns regarding the continuity and quality of care as well as equitable access. There is a paucity of research documenting the availability of virtual care in Canada, thus hampering the efforts to evaluate the impacts of its relatively rapid emergence on the broader health care system and on individual health.

Objective
We conducted a national environmental scan to determine the availability and scope of virtual walk-in clinics, cataloging the services they offer and whether they are operating through public or private payment.

Methods
We developed a power term and implemented a structured Google search to identify relevant clinics. From each clinic meeting our inclusion criteria, we abstracted data on the payment model, region of operation, services offered, and continuity of care. We compared clinics operating under different payment models using Fisher exact tests.

Results
We identified 18 virtual walk-in clinics. Of the 18 clinics, 10 (56%) provided some services under provincial public insurance, although 44% (8/18) operated on a fully private payment model while an additional 39% (7/18) charged patients out of pocket for some services. The most common supplemental services offered included dermatology (15/18, 83%), mental health services (14/18, 78%), and sexual health (11/18, 61%). Continuity, information sharing, or communication with the consumers’ existing primary care providers were mentioned by 22% (4/18) of the clinics.

Conclusions
Virtual walk-in clinics have proliferated; however, concerns about equitable access, continuity of care, and diversion of physician workforce within these models highlight the importance of supporting virtual care options within the context of longitudinal primary care. More research is needed to support quality virtual care and understand its effects on patient and provider experiences and the overall health system utilization and costs.
Design, Implementation, and Examination of a Remote Patient Monitoring System for Pediatric Obesity: Protocol for an Open Trial Pilot Study
Authors: Lim Crystal , Rutledge Laura , Sandridge Shanda , King Krista , Jefferson Darryl , Tucker Tanya 
Published: June 2021

Background
Pediatric obesity is a critical public health issue. Augmenting care in multidisciplinary pediatric obesity clinics with innovative evidence-based technology to improve weight status and health outcomes is needed.

Objective
This study describes the design and methods of an open trial pilot study to examine a remote patient monitoring system (RPMS) for children aged 8-17 years who are receiving treatment in a multidisciplinary pediatric obesity clinic.

Methods
Participants will include 45 youth with obesity and their parents. Families will receive standard care in the clinic and the RPMS for 3 months. The RPMS consists of a tablet, weight scale, and pedometer. The system provides daily educational content and involves the use of the pedometer and weekly weigh-ins. Children and parents will complete baseline, posttreatment (month 3), and follow-up assessments (month 6). The primary aim of the study is to examine feasibility and satisfaction with the RPMS and assess its initial effectiveness.

Results
We hypothesize high feasibility and satisfaction, with rates over 75%. Furthermore, after RPMS treatment, children will exhibit improved weight status, health outcomes, dietary intake, physical activity, health-related quality of life, self-efficacy, and home-food environment compared to before treatment. These gains are expected to persist at follow-up.

Conclusions
This study is novel in that it is the first to design, implement, and examine an RPMS in a pediatric obesity clinic. If the RPMS is feasible, effective, and easily accessible, it may prove to be a practical, acceptable, and cost-effective weight management treatment for youth seeking treatment for severe obesity.

Trial Registration
ClinicalTrials.gov NCT04029597; https://clinicaltrials.gov/ct2/show/NCT04029597

International Registered Report Identifier (IRRID)
DERR1-10.2196/29858
Gestión y liderazgo del talento: las claves del éxito empresarial
Authors: Luna-Arocas Roberto 
Published: June 2021

Desde hace ya unas décadas, se está trabajando con profundidad en la investigación científica sobre la evidencia en las empresas de la gestión del talento. A nivel profesional, ya han sido muchas organizaciones las que han dado el salto cualitativo hacia una nueva manera de enfocar los recursos humanos (RR. HH.). Principalmente porque esta nueva perspectiva está más vinculada tanto al negocio como a los objetivos empresariales, además de ser más aceptada por la mayoría de los profesionales.
Desde los orígenes de la guerra del talento por Mckinsey hasta la actualidad, la investigación está analizando el papel de la gestión del talento en los resultados organizativos. En este sentido, Luna (2018) diseñó un modelo de gestión del talento basado en siete variables: el modelo 7GT. Este modelo contiene tres variables sistémicas que afectan a toda la organización y cuatro variables estratégicas, y aparte de implementarse en muchas organizaciones, está siendo también investigado científicamente. Del mismo modo, Luna (2021) se dio cuenta de que de nada serviría formular una nueva manera de dirigir personas basada en el talento si no se daba un cambio en el liderazgo de gran parte de las organizaciones. Por eso mismo, diseñó un modelo de seis variables para liderar desde el talento.
Se analizan las implicaciones de ambos modelos en el mundo organizativo y empresarial, así como se profundiza en las variables que lo componen.
Oral Glucose Tolerance Test Results in Pregnancy Can Be Used to Individualize the Risk of Future Maternal Type 2 Diabetes Mellitus in Women With Gestational Diabetes Mellitus
Authors: Hiersch Liran , Shah Baiju R. , Berger Howard , Geary Michael , McDonald Sarah D. , Murray-Davis Beth , Halperin Ilana , Retnakaran Ravi , Barrett Jon , Melamed Nir 
Published: June 2021

OBJECTIVE
We aimed to quantify the risk of future maternal type 2 diabetes mellitus (T2DM) in women with gestational diabetes mellitus (GDM) based on the type and number of abnormal 75-g oral glucose tolerance test (OGTT) values and the diagnostic criteria used for the diagnosis of GDM.

RESEARCH DESIGN AND METHODS
We conducted a population-based retrospective cohort study of all nulliparous women with a live singleton birth who underwent testing for GDM using a 75-g OGTT in Ontario, Canada (2007–2017). We estimated the incidence rate (per 1,000 person-years), overall risk (expressed as adjusted hazard ratio [aHR]), and risk at 5 years after the index pregnancy of future maternal T2DM. Estimates were stratified by the type and number of abnormal OGTT values, as well as by the diagnostic criteria for GDM (Diabetes Canada [DC] vs. International Association of the Diabetes and Pregnancy Study Groups [IADPSG] criteria).

RESULTS
A total of 55,361 women met the study criteria. The median duration of follow-up was 4.4 (interquartile range 2.8–6.3; maximum 10.3) years. Using women without GDM as reference (incidence rate 2.18 per 1,000 person-years), women with GDM were at an increased risk of future T2DM; this risk was greater when using the DC compared with the IADPSG criteria (incidence rate 18.74 [95% CI 17.58–19.90] vs. 14.07 [95% CI 13.24–14.91] per 1,000 person-years, respectively). The risk of future maternal T2DM increased with the number of abnormal OGTT values and was highest for women with three abnormal values (incidence rate 49.93 per 1,000 person-years; aHR 24.57 [95% CI 21.26–28.39]). The risk of future T2DM was also affected by the type of OGTT abnormality: women with an abnormal fasting value had the greatest risk, whereas women with an abnormal 2-h value had the lowest risk (aHR 14.09 [95% CI 12.46–15.93] vs. 9.22 [95% CI 8.19–10.37], respectively). Similar findings to those described above were observed when the risk of T2DM at a fixed time point of 5 years after the index pregnancy was considered as the outcome of interest.

CONCLUSIONS
In women with GDM, individualized information regarding the future risk of T2DM can be provided based on the type and number of abnormal OGTT values, as well as the diagnostic criteria used for the diagnosis of GDM.