bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optical dispersion equations for metals applicable to the Far-IR through EUV spectral range
Authors: Forouhi A R , Bloomer I 
Published: February 2021

Abstract
The long-standing problem of finding a general formulation of optical dispersion for metals, valid over a wide spectral range of photon energy E is tackled. To this end, equations for refractive index n and extinction coefficient k as functions of E are developed. Functions

n

E

and

k

E

respectively represent real and imaginary parts of complex index of refraction

N

E

.

Previous formulations, most of which are based on various combinations of Drude and Lorentz models, are either useable only over a limited spectral range or do not accurately fit experimental data. The formulation overcomes these shortcomings by exploiting concepts set forth by Forouhi and Bloomer in 1986, 1988 and 2019 publications pertaining to optical dispersion of semiconductors and insulators. These concepts are centered on time-dependent perturbation theory and consistency with principle of causality. The new expression for

k

E

is based on three types of events initiated by photon-electron interactions in metals: intraband electron dipole transitions; interband electron dipole transitions; inelastic collisions of electrons. Expression for

n

E

is obtained as Hilbert transform of

k

E

.

It is demonstrated that the new dispersion equations satisfy Titchmarsh’s Theorem, a mathematical theorem that conveys the principle of causality, which in turn establishes the theoretical validity of the formulation. Equations for

n

E

and

k

E

are fitted to published experimental data of metals encompassing all metal groups of the periodic table. Reported data span various ranges of energy, from far-infrared to extreme-ultraviolet. Excellent fits between calculated and experimental spectra are achieved. Having established consistency with Titchmarsh’s Theorem and by extension, causality, plus agreement with experimental findings suggests this formulation represents a valid description of optical dispersion of metals.
Balance and cognitive decline in older adults in the cardiovascular health study
Authors: Meunier Claire C , Smit Ellen , Fitzpatrick Annette L , Odden Michelle C 
Published: February 2021

Abstract

Background
Previous studies have demonstrated an association between gait speed and cognitive function. However, the relationship between balance and cognition remains less well explored. This study examined the cross-sectional and longitudinal relationship of balance and cognitive decline in older adults.

Methods
A cohort of 4,811 adults, aged ≥65 years, participating in the Cardiovascular Health Study was followed for 6 years. Modified Mini-Mental State Examination (3MSE) and Digit Symbol Substitution Test (DSST) were used to measure cognition. Tandem balance measures were used to evaluate balance. Regression models were adjusted for demographics, behavioural and disease factors.

Results
Worse balance was independently associated with worse cognition in cross-sectional analysis. Longitudinally, participants aged ≥76 years with poorer balance had a faster rate of decline after adjustment for co-variates: −0.97 points faster decline in 3MSE per year (95% confidence interval (CI): −1.32, −0.63) compared to the participants with good balance. There was no association of balance and change in 3MSE among adults aged &lt;76 years (P value for balance and age interaction &lt; 0.0001). DSST scores reflected −0.21 (95% CI: −0.37, −0.05) points greater decline when adjusted for co-variates. In Cox proportional hazard models, participants with worse balance had a higher risk of being cognitively impaired over the 6 years of follow-up visits (adjusted HR:1.72, 95% CI: 1.30, 2.29).

Conclusions
Future studies should evaluate standing balance as a potential screening technique to identify individuals at risk of cognitive decline. Furthermore, a better understanding of the pathophysiological link between balance and cognition may inform strategies to prevent cognitive decline.
Synergistic Effects of Autologous Platelet-Rich Plasma and Hyaluronic Acid Injections on Facial Skin Rejuvenation
Authors: Hersant Barbara , SidAhmed-Mezi Mounia , Aboud Celine , Niddam Jeremy , Levy Samuel , Mernier Thibaud , La Padula Simone , Meningaud Jean-Paul 
Published: February 2021

Abstract

Background
Many therapeutic options are currently available for facial skin rejuvenation, but little evidence exists about the efficacy of combining such procedures.

Objectives
The aim of this study was to assess and investigate the synergistic effect of hyaluronic acid (HA) and autologous platelet-rich plasma (a-PRP) injections on facial skin rejuvenation.

Methods
For this randomized controlled prospective study, 93 eligible patients were enrolled and randomized into 3 intervention groups to undergo a series of 3 treatment sessions with either a-PRP, HA, or a mixture of a-PRP and HA (Cellular Matrix; Regen Lab) injected into facial cheeks.

Results
A total of 93 patients were included. Treatment with Cellular Matrix led to a very significant improvement in the overall facial appearance compared with treatment with a-PRP or HA alone (P &lt; 0.0001). Participants treated with Cellular Matrix showed a 20%, 24%, and 17% increase in FACE-Q score at 1, 3, and 6 months posttreatment, respectively. For the HA group, the improvement in FACE-Q score was 12%, 11%, and 6% at 1, 3, and 6 months posttreatment, respectively, whereas for the a-PRP group the improvement was 9%, 11%, and 8% at 1, 3, and 6 months posttreatment, respectively. Biophysical measurements showed significantly improved skin elasticity for the Cellular Matrix group compared with the groups receiving a-PRP or HA alone. No serious adverse events were reported.

Conclusions
Combining a-PRP and HA seems to be a promising treatment for facial rejuvenation with a highly significant improvement in facial appearance and skin elasticity compared with a-PRP or HA alone.

Level of Evidence: 3
Activation of bovine oocytes by protein synthesis inhibitors: new findings on the role of MPF/MAPKs†
Authors: Valencia Cecilia , Pérez Felipe Alonso , Matus Carola , Felmer Ricardo , Arias María Elena 
Published: February 2021

Abstract
The present study evaluated the mechanism by which protein synthesis inhibitors activate bovine oocytes. The aim was to analyze the dynamics of MPF and MAPKs. MII oocytes were activated with ionomycin (Io), ionomycin+anisomycin (ANY) and ionomycin+cycloheximide (CHX) and by in vitro fertilization (IVF). The expression of cyclin B1, p-CDK1, p-ERK1/2, p-JNK, and p-P38 were evaluated by immunodetection and the kinase activity of ERK1/2 was measured by enzyme assay. Evaluations at 1, 4, and 15 hours postactivation (hpa) showed that the expression of cyclin B1 was not modified by the treatments. ANY inactivated MPF by p-CDK1Thr14-Tyr15 at 4 hpa (P &lt; 0.05), CHX increased pre-MPF (p-CDK1Thr161 and p-CDK1Thr14-Tyr15) at 1 hpa and IVF increased p-CDK1Thr14-Tyr15 at 17 hours postfertilization (hpf) (P &lt; 0.05). ANY and CHX reduced the levels of p-ERK1/2 at 4 hpa (P &lt; 0.05) and its activity at 4 and 1 hpa, respectively (P &lt; 0.05). Meanwhile, IVF increased p-ERK1/2 at 6 hpf (P &lt; 0.05); however, its kinase activity decreased at 6 hpf (P &lt; 0.05). p-JNK in ANY, CHX, and IVF oocytes decreased at 4 hpa (P &lt; 0.05). p-P38 was only observed at 1 hpa, with no differences between treatments. In conclusion, activation of bovine oocytes by ANY, CHX, and IVF inactivates MPF by CDK1-dependent specific phosphorylation without cyclin B1 degradation. ANY or CHX promoted this inactivation, which seemed to be more delayed in the physiological activation (IVF). Both inhibitors modulated MPF activity via an ERK1/2-independent pathway, whereas IVF activated the bovine oocytes via an ERK1/2-dependent pathway. Finally, ANY does not activate the JNK and P38 kinase pathways.
Anterior resection syndrome: a randomized clinical trial of a 5-HT3 receptor antagonist (ramosetron) in male patients with rectal cancer
Authors: Ryoo S -B , Park J W , Lee D W , Lee M A , Kwon Y -H , Kim M J , Moon S H , Jeong S -Y , Park K J 
Published: February 2021

Abstract

Background
No effective treatment exists for anterior resection syndrome (ARS) following sphincter-saving surgery for rectal cancer. This RCT assessed the safety and efficacy of a 5-HT3 receptor antagonist, ramosetron, for ARS.

Methods
A single-centre, randomized, controlled, open-label, parallel group trial was conducted. Male patients with ARS 1 month after rectal cancer surgery or ileostomy reversal were enrolled and randomly assigned (1 : 1) to 5 μg of ramosetron (Irribow®) daily or conservative treatment for 4 weeks. Low ARS (LARS) score was calculated after randomization and 4 weeks after treatment. The study was designed as a superiority test with a primary endpoint of the proportion of patients with major LARS between the groups. Primary outcome analysis was based on the modified intention-to-treat population. Safety was assessed by monitoring adverse events during the study.

Results
A total of 100 patients were randomized to the ramosetron (49 patients) or conservative treatment group (51 patients). Two patients were excluded, and 48 and 50 patients were analysed in the ramosetron and control groups, respectively. The proportion of major LARS after 4 weeks was 58 per cent (28 of 48 patients) in the ramosetron group versus 82 per cent (41 of 50 patients) in the control group, with a difference of 23.7 per cent (95 per cent c.i. 5.58 to 39.98, P = 0.011). There were minor adverse events in five patients, which were hard stool, frequent stool or anal pain. These were not different between the two groups. There were no serious adverse events.

Conclusion
Ramosetron could be safe and feasible for male patients with ARS.

Trial registration number
NCT02869984 (http://www.clinicaltrials.gov).
Influence of Holding Conditions and Storage Duration ofHalyomorpha halys(Hemiptera: Pentatomidae) Eggs on Adventive and Quarantine Populations ofTrissolcus japonicus(Hymenoptera: Scelionidae) Behavior and Parasitism Success
Authors: Ludwick Dalton C , Leake Layne B , Morrison William R , Lara Jesús R , Hoddle Mark S , Talamas Elijah J , Leskey Tracy C 
Published: February 2021

AbstractHalyomorpha halys (Stål) is an invasive pest in the United States and other countries. In its native range, H. halys eggs are parasitized by a co-evolved parasitoid, Trissolcus japonicus (Ashmead). In the United States, T. japonicus, a classical biological control candidate, is being redistributed in many states where adventive populations exist. To establish if H. halys egg holding conditions affect T. japonicus foraging behavior or successful parasitism, naïve, female parasitoids from an adventive population were allowed to forage in laboratory bioassay arenas with either fresh or frozen (−20 or −80°C) egg masses, the latter held for five durations ranging from 1 h to 112 d. Parasitoid movements were recorded for 1 h. Thereafter, parasitoids were transferred with the same egg mass for 23 h. Additionally, female parasitoids from a quarantine colony were exposed to: 1) pairs of fresh egg masses and egg masses frozen at −40°C (&gt;24 h) or 2) a single fresh egg mass or egg mass frozen at −40°C (&lt;1 h). All exposed egg masses were held to assess progeny emergence. In the foraging bioassay, holding temperature and storage duration appeared to influence host-finding and host quality. Egg masses held at −80°C and fresh egg masses resulted in significantly greater levels of parasitism and progeny emergence compared with eggs held at −20°C. No differences were recorded between egg masses held at −40°C for ≤1 h and fresh egg masses. These results will help refine methods for preparation of egg masses for sentinel monitoring and parasitoid mass rearing protocols.
Cucumis melopectin as potential candidate to control herpes simplex virus infection
Authors: Agostinho Karoline Fontana , Rechenchoski Daniele Zendrini , Faccin-Galhardi Ligia Carla , de Sousa André Luiz Nascimento , Cunha Arcelina Pacheco , Ricardo Nágila Maria Pontes Silva , Linhares Rosa Elisa Carvalho , Nozawa Carlos 
Published: February 2021

ABSTRACTThe herpes simplex virus, also known as HSV, is an important human pathogen. Acyclovir (ACV) is the first-line antiviral for the treatment of HSV infections; nevertheless HSV resistance to ACV has been increasingly reported and, therefore, search for alternative drugs have been encouraged. Herein, the effect of Cucumis melo sulfated pectin (SPCm) was evaluated in the HSV-1 infection. Pectin cytotoxicity and its antiherpetic action were determined by assays of MTT and plaque reduction, respectively. The SPCm concentration that reduced the cell viability by 50% (CC50) was 1440 μg/mL, while the concentration that reduced PFU in 50% (IC50) was 6 μg/mL against ACV-sensitive (KOS) strain and 12 μg/mL for ACV-resistant (AR-29) strain. The pectin showed high selectivity index (SI) for both viral strains. Therefore, we suggest that SPCm has been effective for HSV-1, strenghten by viral protein and DNA syntheses inhibition. In conclusion, we have found that SPCm is a promising alternative compound to control HSV infection.
Obtaining Evidence in Patent Litigation and Trade Secret Protection – A Tale of Two Poles
Authors: Schröder Vilhelm , Widera Philipp 
Published: February 2021

Abstract
In this article, the authors compare how the courts in two different jurisdictions handle trade secrets in patent litigation. Even though the two countries observed, Finland and Germany, are both continental European civil law systems with similar legal traditions, the approach to trade secret protection in litigation is quite different in many aspects. While Finland already has comparatively sophisticated legislation and jurisprudence when it comes to the protection of trade secrets, the German approach is rather different, and could be compared to a patchwork carpet. In this article, the authors review the international and European legal framework before delving into the details of the two national legal systems. Finally, they give guidelines on how to harmonize trade secret protection in litigation in order to strike a fair balance between the different interests at stake.
Evaluation of a U.S. National Cohort to Determine Utilization in Colectomy Rates for Ulcerative Colitis Among Ethnicities
Authors: Bhurwal Abhishek , Minacapelli Carlos D , Patel Anish , Mutneja Hemant , Goel Akshay , Shah Ishani , Bansal Vikas , Brahmbhatt Bhaumik , Das Kiron M 
Published: February 2021

Abstract

Background
Colectomy is the curative management for ulcerative colitis (UC). Multiple studies have reported racial disparities for colectomy before the advent of anti-TNF alpha agents. The aim of this study was to describe racial and geographic differences in colectomy rates among hospitalized patients with UC after anti-TNF therapy was introduced.

Methods
We examined all patients discharged from the hospital between 2010 and 2014 with a primary diagnosis of UC or of complications of UC. The data were evaluated for race and colectomy rates among the hospitalized patients with UC.

Results
The unadjusted national colectomy rate among hospitalized patients with UC between 2010 and 2014 was 3.90 per 1000 hospitalization days (95% confidence interval, 3.72-4.08). The undajusted colectomy rates in African American (2.33 vs 4.35; P &lt; 0.001) and Hispanic patients (3.99 vs 4.35; P ≤ 0.009) were considerably lower than those for White patients. After adjustment for confounders, the incidence rate ratio for African American as compared to White patients was 0.43 (95% confidence interval, 0.32-0.58; P &lt; 0.001). Geographic region of the United States also showed significant variation in colectomy rates, with western regions having the highest rate (4.76 vs 3.20; P &lt; 0.001).

Conclusions
Racial and geographical disparities persist for the rate of colectomy among hospitalized patients with UC. The national database analysis reveals that colectomy rates for hospitalized African American and Hispanic patients were lower than those for White patients. Further studies are important to determine the social and biologic foundations of these disparities.
Counterintuitive active directional swimming behaviour by Atlantic salmon during seaward migration in the coastal zone
Authors: Newton Matthew , Barry James , Lothian Angus , Main Robert , Honkanen Hannele , Mckelvey Simon , Thompson Paul , Davies Ian , Brockie Nick , Stephen Alastair , Murray Rory O’Hara , Gardiner Ross , Campbell Louise , Stainer Paul , Adams Colin 
Published: February 2021

Abstract
Acoustic telemetry was used to track salmon smolts during river migration and into the open marine coastal zone. We compared migration direction and speed with particle tracking simulations to test the hypothesis that marine migration pathways are defined by active swimming current following behaviour. Habitat-specific survival rates, movement speeds, depths and directions in riverine, estuarine, and coastal habitats were also quantified. Salmon post-smolts did not disperse at random as they entered the unrestricted, coastal zone of the North sea; rather they chose a common migration pathway. This was not the most direct route to marine feeding grounds (ca. 44° N); north in the direction of the prevailing currents. Particle modelling showed that the actual post-smolt migration route was best predicted by active swimming at 1.2 body length.sec.−1 at a bearing of 70° from north but not by current following behaviour. Fish migrating in larger groups and earlier in the migration period had increased migration success. We conclude that: post-smolts have preferred migration routes that are not predicted by the shortest direction to their ultimate destination; they do not simply use the current advantage to migrate; and that they actively swim, occasionally directly against the current prevailing at the time.
The Distribution of Spacings Between the Fractional Parts of ndα
Authors: Fassina Martino , Kim Sun , Zaharescu Alexandru 
Published: February 2021

Abstract
We study the distribution of spacings between the fractional parts of $n^d\alpha $. For $\alpha $ of high enough Diophantine type we prove a necessary and sufficient condition for $n^d\alpha \mod 1, 1\leq n\leq N,$ to be Poissonian as $N\to \infty $ along a suitable subsequence.
Advancements in sensor technology and decision support intelligent tools to assist smart livestock farming
Authors: Tedeschi Luis O , Greenwood Paul L , Halachmi Ilan 
Published: February 2021

AbstractRemote monitoring, modern data collection through sensors, rapid data transfer, and vast data storage through the Internet of Things (IoT) have advanced precision livestock farming (PLF) in the last 20 yr. PLF is relevant to many fields of livestock production, including aerial- and satellite-based measurement of pasture’s forage quantity and quality; body weight and composition and physiological assessments; on-animal devices to monitor location, activity, and behaviors in grazing and foraging environments; early detection of lameness and other diseases; milk yield and composition; reproductive measurements and calving diseases; and feed intake and greenhouse gas emissions, to name just a few. There are many possibilities to improve animal production through PLF, but the combination of PLF and computer modeling is necessary to facilitate on-farm applicability. Concept- or knowledge-driven (mechanistic) models are established on scientific knowledge, and they are based on the conceptualization of hypotheses about variable interrelationships. Artificial intelligence (AI), on the other hand, is a data-driven approach that can manipulate and represent the big data accumulated by sensors and IoT. Still, it cannot explicitly explain the underlying assumptions of the intrinsic relationships in the data core because it lacks the wisdom that confers understanding and principles. The lack of wisdom in AI is because everything revolves around numbers. The associations among the numbers are obtained through the “automatized” learning process of mathematical correlations and covariances, not through “human causation” and abstract conceptualization of physiological or production principles. AI starts with comparative analogies to establish concepts and provides memory for future comparisons. Then, the learning process evolves from seeking wisdom through the systematic use of reasoning. AI is a relatively novel concept in many science fields. It may well be “the missing link” to expedite the transition of the traditional maximizing output mentality to a more mindful purpose of optimizing production efficiency while alleviating resource allocation for production. The integration between concept- and data-driven modeling through parallel hybridization of mechanistic and AI models will yield a hybrid intelligent mechanistic model that, along with data collection through PLF, is paramount to transcend the current status of livestock production in achieving sustainability.
A chlorophyll a oxygenase 1 gene ZmCAO1 contributes to grain yield and waterlogging tolerance in maize
Authors: Li Qin , Zhou Shuangzhen , Liu Wenyu , Zhai Zhensheng , Pan Yitian , Liu Changchang , Chern Mawsheng , Wang Hongwei , Huang Min , Zhang Zuxin , Tang Jihua , Du Hewei 
Published: February 2021

Abstract
Chlorophylls function in photosynthesis, and are critical to plant developmental processes and responses to environmental stimuli. Chlorophyll b is synthesized from chlorophyll a by chlorophyll a oxygenase (CAO). Here, we characterize a yellow-green leaf (ygl) mutant and identify the causal gene which encodes a chlorophyll a oxygenase in maize (ZmCAO1). A 51 bp Popin transposon insertion in ZmCAO1 strongly disrupts its transcription. Low enzyme activity of ZmCAO1 leads to reduced concentrations of chlorophyll a and chlorophyll b, resulting in the yellow-green leaf phenotype of the ygl mutant. The net photosynthetic rate, stomatal conductance, and transpiration rate are decreased in the ygl mutant, while concentrations of δ-aminolevulinic acid (ALA), porphobilinogen (PBG) and protochlorophyllide (Pchlide) are increased. In addition, a ZmCAO1 mutation results in down-regulation of key photosynthetic genes, limits photosynthetic assimilation, and reduces plant height, ear size, kernel weight, and grain yield. Furthermore, the zmcao1 mutant shows enhanced reactive oxygen species production leading to sensitivity to waterlogging. These results demonstrate the pleiotropy of ZmCAO1 function in photosynthesis, grain yield, and waterlogging tolerance in maize.
A tidally tilted sectoral dipole pulsation mode in the eclipsing binary TIC 63328020
Authors: Rappaport S A , Kurtz D W , Handler G , Jones D , Nelson L A , Saio H , Fuller J , Holdsworth D L , Vanderburg A , Žák J , Skarka M , Aiken J , Maxted P F L , Stevens D J , Feliz D L , Aliçavuş F Kahraman 
Published: February 2021

Abstract
We report the discovery of the third tidally tilted pulsator, TIC 63328020. Observations with the TESS satellite reveal binary eclipses with an orbital period of 1.1057 d, and δ Scuti-type pulsations with a mode frequency of 21.09533 d−1. This pulsation exhibits a septuplet of orbital sidelobes as well as a harmonic quintuplet. Using the oblique pulsator model, the primary oscillation is identified as a sectoral dipole mode with l = 1, |m| = 1. We find the pulsating star to have M1 ≃ 2.5 M⊙, R1 ≃ 3 R⊙, and Teff, 1 ≃ 8000 K, while the secondary has M2 ≃ 1.1 M⊙, R2 ≃ 2 R⊙, and Teff, 2 ≃ 5600 K. Both stars appear to be close to filling their respective Roche lobes. The properties of this binary as well as the tidally tilted pulsations differ from the previous two tidally tilted pulsators, HD74423 and CO Cam, in important ways. We also study the prior history of this system with binary evolution models and conclude that extensive mass transfer has occurred from the current secondary to the primary.