bluuebunny/crossref_metadata_2025_split huggingface dataset:
BMS field theories and Weyl anomaly
Authors: Bagchi Arjun , Dutta Sudipta , Kolekar Kedar S. , Sharma Punit 
Published: July 2021

Abstract
Two dimensional field theories with Bondi-Metzner-Sachs symmetry have been proposed as duals to asymptotically flat spacetimes in three dimensions. These field theories are naturally defined on null surfaces and hence are conformal cousins of Carrollian theories, where the speed of light goes to zero. In this paper, we initiate an investigation of anomalies in these field theories. Specifically, we focus on the BMS equivalent of Weyl invariance and its breakdown in these field theories and derive an expression for Weyl anomaly. Considering the transformation of partition functions under this symmetry, we derive a Carrollian Liouville action different from ones obtained in the literature earlier.
Geometry of orientifold vacua and supersymmetry breaking
Authors: Coudarchet Thibaut , Dudas Emilian , Partouche Hervé 
Published: July 2021

AbstractStarting from a peculiar orientifold projection proposed long ago by Angelantonj and Cardella, we elaborate on a novel perturbative scenario that involves only D-branes, together with the two types of orientifold planes O±and anti-orientifold planes$$ {\overline{\mathrm{O}}}_{\pm } $$O¯±. We elucidate the microscopic ingredients of such models, connecting them to a novel realization of brane supersymmetry breaking. Depending on the position of the D-branes in the internal space, supersymmetry can be broken at the string scale on branes, or alternatively only at the massive level. The main novelty of this construction is that it features no NS-NS disk tadpoles, while avoiding open-string instabilities. The one-loop potential, which depends on the positions of the D-branes, is minimized for maximally broken, non-linearly realized supersymmetry. The orientifold projection and the effective field theory description reveal a soft breaking of supersymmetry in the closed-string sector. In such models it is possible to decouple the gravitino mass from the value of the scalar potential, while avoiding brane instabilities.
How a four-dimensional de Sitter solution remains outside the swampland
Authors: Dasgupta Keshav , Emelin Maxim , Faruk Mir Mehedi , Tatar Radu 
Published: July 2021

Abstract
We argue that, in the presence of time-dependent fluxes and quantum corrections, four-dimensional de Sitter solutions should appear in the type IIB string landscape and not in the swampland. Our construction considers generic choices of local and non-local quantum terms and satisfies the no-go and the swampland criteria, the latter being recently upgraded using the trans-Planckian cosmic censorship. Interestingly, both time-independent Newton constant and moduli stabilization may be achieved in such backgrounds even in the presence of time-dependent fluxes and internal spaces. However, once the time-dependence is switched off, any four-dimensional solution with de Sitter isometries appears to have no simple effective field theory descriptions and is back in the swampland.
Modelling of BCS1L-related human mitochondrial disease in Drosophila melanogaster
Authors: Brischigliaro Michele , Frigo Elena , Corrà Samantha , De Pittà Cristiano , Szabò Ildikò , Zeviani Massimo , Costa Rodolfo 
Published: July 2021

AbstractMutations in BCS1L are the most frequent cause of human mitochondrial disease linked to complex III deficiency. Different forms of BCS1L-related diseases and more than 20 pathogenic alleles have been reported to date. Clinical symptoms are highly heterogenous, and multisystem involvement is often present, with liver and brain being the most frequently affected organs. BCS1L encodes a mitochondrial AAA + -family member with essential roles in the latest steps in the biogenesis of mitochondrial respiratory chain complex III. Since Bcs1 has been investigated mostly in yeast and mammals, its function in invertebrates remains largely unknown. Here, we describe the phenotypical, biochemical and metabolic consequences of Bcs1 genetic manipulation in Drosophila melanogaster. Our data demonstrate the fundamental role of Bcs1 in complex III biogenesis in invertebrates and provide novel, reliable models for BCS1L-related human mitochondrial diseases. These models recapitulate several features of the human disorders, collectively pointing to a crucial role of Bcs1 and, in turn, of complex III, in development, organismal fitness and physiology of several tissues.
Metabolomic analysis to discriminate drug-induced liver injury (DILI) phenotypes
Authors: Quintás Guillermo , Martínez-Sena Teresa , Conde Isabel , Pareja Ibars Eugenia , Kleinjans Jos , Castell José V. 
Published: July 2021

AbstractDrug-induced liver injury (DILI) is an adverse toxic hepatic clinical reaction associated to the administration of a drug that can occur both at early clinical stages of drug development, as well after normal clinical usage of approved drugs. Because of its unpredictability and clinical relevance, it is of medical concern. Three DILI phenotypes (hepatocellular, cholestatic, and mixed) are currently recognized, based on serum alanine aminotransferase (ALT) and alkaline phosphatase (ALP) values. However, this classification lacks accuracy to distinguish among the many intermediate mixed types, or even to estimate the magnitude and progression of the injury. It was found desirable to have additional elements for better evaluation criteria of DILI. With this aim, we have examined the serum metabolomic changes occurring in 79 DILI patients recruited and monitored using established clinical criteria, along the course of the disease and until recovery. Results revealed that free and conjugated bile acids, and glycerophospholipids were among the most relevant metabolite classes for DILI phenotype characterization. Using an ensemble of PLS–DA models, metabolomic information was integrated into a ternary diagram to display the disease phenotype, the severity of the liver damage, and its progression. The modeling implemented and the use of such compiled information in an easily understandable and visual manner facilitates a straightforward DILI phenotyping and allow to monitor its progression and recovery prediction, usefully complementing the concise information drawn out by the ALT and ALP classification.
Operando tracking of oxidation-state changes by coupling electrochemistry with time-resolved X-ray absorption spectroscopy demonstrated for water oxidation by a cobalt-based catalyst film
Authors: Pasquini Chiara , Liu Si , Chernev Petko , Gonzalez-Flores Diego , Mohammadi Mohammad Reza , Kubella Paul , Jiang Shan , Loos Stefan , Klingan Katharina , Sikolenko Vadim , Mebs Stefan , Haumann Michael , Beyer Paul , D’Amario Luca , Smith Rodney D. L. , Zaharieva Ivelina , Dau Holger 
Published: July 2021

AbstractTransition metal oxides are promising electrocatalysts for water oxidation, i.e., the oxygen evolution reaction (OER), which is critical in electrochemical production of non-fossil fuels. The involvement of oxidation state changes of the metal in OER electrocatalysis is increasingly recognized in the literature. Tracing these oxidation states under operation conditions could provide relevant information for performance optimization and development of durable catalysts, but further methodical developments are needed. Here, we propose a strategy to use single-energy X-ray absorption spectroscopy for monitoring metal oxidation-state changes during OER operation with millisecond time resolution. The procedure to obtain time-resolved oxidation state values, using two calibration curves, is explained in detail. We demonstrate the significance of this approach as well as possible sources of data misinterpretation. We conclude that the combination of X-ray absorption spectroscopy with electrochemical techniques allows us to investigate the kinetics of redox transitions and to distinguish the catalytic current from the redox current. Tracking of the oxidation state changes of Co ions in electrodeposited oxide films during cyclic voltammetry in neutral pH electrolyte serves as a proof of principle.
Graphical abstract
Bin packing with lexicographic objectives for loading weight- and volume-constrained trucks in a direct-shipping system
Authors: Heßler Katrin , Irnich Stefan , Kreiter Tobias , Pferschy Ulrich 
Published: July 2021

AbstractWe consider a packing problem that arises in a direct-shipping system in the food and beverage industry: Trucks are the containers, and products to be distributed are the items. The packing is constrained by two independent quantities, weight (e.g., measured in kg) and volume (number of pallets). Additionally, the products are grouped into the three categories: standard, cooled, and frozen (the latter two require refrigerated trucks). Products of different categories can be transported in one truck using separated zones, but the cost of a truck depends on the transported product categories. Moreover, splitting orders of a product should be avoided so that (un-)loading is simplified. As a result, we seek for a feasible packing optimizing the following objective functions in a strictly lexicographic sense: minimize the (1) total number of trucks; (2) number of refrigerated trucks; (3) number of refrigerated trucks which contain frozen products; (4) number of refrigerated trucks which also transport standard products; (5) and minimize splitting. This is a real-world application of a bin-packing problem with cardinality constraints a.k.a. the two-dimensional vector packing problem with additional constraints. We provide a heuristic and an exact solution approach. The heuristic meta-scheme considers the multi-compartment and item fragmentation features of the problem and applies various problem-specific heuristics. The exact solution algorithm covering all five stages is based on branch-and-price using stabilization techniques exploiting dual-optimal inequalities. Computational results on real-world and difficult self-generated instances prove the applicability of our approach.
Differences in treatment choices between prostate cancer patients using a decision aid and patients receiving care as usual: results from a randomized controlled trial
Authors: Lamers Romy E. D. , Cuypers Maarten , de Vries Marieke , van de Poll-Franse Lonneke V. , Bosch J. L. H. Ruud , Kil Paul J. M. 
Published: July 2021

Abstract
Objective
To determine whether or not decision aid (DA) use influences treatment decisions in patients with low and intermediate risk prostate cancer (PC).

Patients and methods
In a cluster randomized controlled trial, patients were randomized to either DA use (DA group) or no DA use (control group). Between 2014 and 2016, newly diagnosed patients with low or intermediate risk PC were recruited in 18 hospitals in the Netherlands. DA users had access to a web-based DA that provided general PC information, PC-treatment information, and values clarification exercises to elicit personal preferences towards the treatment options. Control group patients received care as usual. Differences in treatment choice were analysed using multilevel logistic regressions. Differences in eligible treatment options between groups were compared using Pearson Chi-square tests.

Results
Informed consent was given by 382 patients (DA group N = 273, control group N = 109). Questionnaire response rate was 88% (N = 336). Active surveillance (AS) was an option for 38%, radical prostatectomy (RP) for 98%, external beam radiotherapy (EBRT) for 88%, and brachytherapy (BT) for 79% of patients. DA users received AS significantly more often than control group. Patients (29 vs 16%, p = 0.01), whereas the latter more often chose BT (29 vs 18%, p < 0.01). No differences were found between groups regarding RP and EBRT. DA users who were not eligible for AS, received surgery more often compared to the control group (53 vs 35%, p = 0.01). Patient and disease characteristics were evenly distributed between groups.

Conclusion
DA-using PC patients chose the AS treatment option more often than non-DA-using patients did.
Early postoperative pain as a marker of anastomotic leakage in colorectal cancer surgery
Authors: Boström Petrus , Svensson Johan , Brorsson Camilla , Rutegård Martin 
Published: July 2021

Abstract
Purpose
Even though anastomotic leakage after colorectal surgery is a major clinical problem in need of a timely diagnosis, early indicators of leakage have been insufficiently studied. We therefore conducted a population-based observational study to determine whether the patient’s early postoperative pain is an independent marker of anastomotic leakage.

Methods
By combining the Swedish Colorectal Cancer Registry and the Swedish Perioperative Registry, we retrieved prospectively collected data on 3084 patients who underwent anastomotic colorectal surgery for cancer in 2014–2017. Postoperative pain, measured with the numerical rating scale (NRS), was considered exposure, while anastomotic leakage and reoperation due to leakage were outcomes. We performed logistic regression to evaluate associations, estimating odds ratios (ORs) and 95% confidence intervals (CIs), while multiple imputation was used to handle missing data.

Results
In total, 189 patients suffered from anastomotic leakage, of whom 121 patients also needed a reoperation due to leakage. Moderate or severe postoperative pain (NRS 4–10) was associated with an increased risk of anastomotic leakage (OR 1.69, 95% CI 1.21–2.38), as well as reoperation (OR 2.17, 95% CI 1.41–3.32). Severe pain (NRS 8–10) was more strongly related to leakage (OR 2.38, 95% CI 1.44–3.93). These associations were confirmed in multivariable analyses and when reoperation due to leakage was used as an outcome.

Conclusion
In this population-based retrospective study on prospectively collected data, increased pain in the post-anaesthesia care unit is an independent marker of anastomotic leakage, possibly indicating a need for further diagnostic measures.
Characterizing the features and course of psychiatric symptoms in children and adolescents with autoimmune encephalitis
Authors: Rosello R , Girela-Serrano B , Gómez S , Baig B , Lim M , Taylor S 
Published: July 2021

AbstractAutoimmune encephalitis (AE) can present like a psychiatric disorder. We aimed to illustrate the psychiatric manifestations, course and management of AE in a paediatric cohort. Neuropsychiatric symptoms, investigations and treatment were retrospectively retrieved in 16 patients (mean age 11.31, SD 2.98) with an AE diagnosis at the liaison psychiatry services in two UK tertiary paediatric centres. Psychiatric presentation was characterised by an acute polysymptomatic (predominantly agitation, anger outbursts/aggressiveness, hallucinations, and emotional lability) onset. Antipsychotics produced side effects and significant worsening of symptoms in four cases, and benzodiazepines were commonly used. This psychiatric phenotype should make clinicians suspect the diagnosis of AE and carefully consider use of treatments.
Reliability of the fMRI-based assessment of self-evaluation in individuals with internet gaming disorder
Authors: Bach Patrick , Hill Holger , Reinhard Iris , Gädeke Theresa , Kiefer Falk , Leménager Tagrid 
Published: July 2021

AbstractThe self-concept—defined as the cognitive representation of beliefs about oneself—determines how individuals view themselves, others, and their actions. A negative self-concept can drive gaming use and internet gaming disorder (IGD). The assessment of the neural correlates of self-evaluation gained popularity to assess the self-concept in individuals with IGD. This attempt, however, seems to critically depend on the reliability of the investigated task-fMRI brain activation. As first study to date, we assessed test–retest reliability of an fMRI self-evaluation task. Test–retest reliability of neural brain activation between two separate fMRI sessions (approximately 12 months apart) was investigated in N = 29 healthy participants and N = 11 individuals with pathological internet gaming. We computed reliability estimates for the different task contrasts (self, a familiar, and an unknown person) and the contrast (self > familiar and unknown person). Data indicated good test–retest reliability of brain activation, captured by the “self”, “familiar person”, and “unknown person” contrasts, in a large network of brain regions in the whole sample (N = 40) and when considering both experimental groups separately. In contrast to that, only a small set of brain regions showed moderate to good reliability, when investigating the contrasts (“self > familiar and unknown person”). The lower reliability of the contrast can be attributed to the fact that the constituting contrast conditions were highly correlated. Future research on self-evaluation should be cautioned by the findings of substantial local reliability differences across the brain and employ methods to overcome these limitations.
Estimating long-term health risks after breast cancer radiotherapy: merging evidence from low and high doses
Authors: Simonetto Cristoforo , Wollschläger Daniel , Kundrát Pavel , Ulanowski Alexander , Becker Janine , Castelletti Noemi , Güthlin Denise , Shemiakina Elena , Eidemüller Markus 
Published: July 2021

AbstractIn breast cancer radiotherapy, substantial radiation exposure of organs other than the treated breast cannot be avoided, potentially inducing second primary cancer or heart disease. While distant organs and large parts of nearby ones receive doses in the mGy–Gy range, small parts of the heart, lung and bone marrow often receive doses as high as 50 Gy. Contemporary treatment planning allows for considerable flexibility in the distribution of this exposure. To optimise treatment with regards to long-term health risks, evidence-based risk estimates are required for the entire broad range of exposures. Here, we thus propose an approach that combines data from medical and epidemiological studies with different exposure conditions. Approximating cancer induction as a local process, we estimate organ cancer risks by integrating organ-specific dose–response relationships over the organ dose distributions. For highly exposed organ parts, specific high-dose risk models based on studies with medical exposure are applied. For organs or their parts receiving relatively low doses, established dose–response models based on radiation-epidemiological data are used. Joining the models in the intermediate dose range leads to a combined, in general non-linear, dose response supported by data over the whole relevant dose range. For heart diseases, a linear model consistent with high- and low-dose studies is presented. The resulting estimates of long-term health risks are largely compatible with rate ratios observed in randomised breast cancer radiotherapy trials. The risk models have been implemented in a software tool PASSOS that estimates long-term risks for individual breast cancer patients.
Frequency of silent brain infarction in transient global amnesia
Authors: Ganeshan Ramanan , Betz Manja , Scheitz Jan F. , Erdur Hebun , Audebert Heinrich J. , Fiebach Jochen B. , Villringer Kersten 
Published: July 2021

Abstract
Background and purpose
To determine the frequency and distribution pattern of acute DWI lesions outside the hippocampus in patients clinically presenting with Transient Global Amnesia (TGA).

Methods
Consecutive patients clinically presenting with TGA between January 2010 and January 2017 admitted to our hospital were retrospectively evaluated. All patients fulfilled diagnostic criteria of TGA. We analyzed imaging and clinical data of all patients undergoing MRI with high-resolution diffusion-weighted imaging within 72 h from symptom onset.

Results
A total of 126 cases were included into the study. Fifty-three percent (n = 71/126) presented with one or more acute lesions in hippocampal CA1-area. Additional acute DWI lesions in other cortical regions were found in 11% (n = 14/126). All patients with DWI lesions outside the hippocampus presented with neurological symptoms typical for TGA (without additional symptoms.)

Conclusions
In a relevant proportion of clinical TGA patients, MRI reveals acute ischemic cerebral lesions. Therefore, cerebral MRI should be performed in patients with TGA to identify a possible cardiac involvement and to detect stroke chameleons.
The effect of adjuvant therapies on long-term outcome for primary resected synovial sarcoma in a series of mainly children and adolescents
Authors: Scheer Monika , Vokuhl Christian , Bauer Sebastian , Fuchs Jörg , Loff Steffan , Timmermann Beate , Münter Marc , Henssen Anton George , Kazanowska Bernarda , Niggli Felix , Ladenstein Ruth , Ljungman Gustaf , Koscielniak Ewa , Klingebiel Thomas ,   the European Cooperative Weichteilsarkom Studiengruppe [CWS]
Published: July 2021

Abstract
Background
The benefit of adjuvant therapy in synovial sarcoma (SS) treatment is under debate. Long-term follow-up data are missing.

Methods
SS patients treated in the consecutive trials CWS-81, CWS-86, CWS-91, CWS-96, CWS-2002-P, and the SoTiSaR-registry till 2013 were analyzed.

Results
Median age of 185 patients was 13.9 years (0.1–56)—with median follow-up of 7.4 years for 163 survivors. Most tumors (76%) were located in extremities. Size was < 3 cm in 58 (31%), 3–5 cm in 59 (32%), 5–10 cm in 42 (23%), and > 10 cm in 13 (7%) (13 missing). In 84 (45%) tumors, first excision was complete (R0 corresponding to IRS-I-group) and in 101 (55%) marginal (R1 corresponding to IRS-II-group). In a subsequent surgical intervention during chemotherapy, R0-status was accomplished in 23 additional IRS-II-group patients with secondary surgery. Radiotherapy was administered to 135 (73%), thereof 62 with R0-status and 67 R1-status (6 missing information). Adjuvant chemotherapy was administered to all but six patients. 5-year event-free (EFS) and overall survival (OS) was 82.9% ± 5.7 (95%CI) and 92.5% ± 3.9. Local and metastatic relapse-free survival was 91.3% ± 4.3 and 92.3% ± 4.1 at 5 years, respectively. In the multivariate analysis, tumor size and no chemotherapy were independently associated with EFS. Size and site were associated with OS. In a detailed analysis of local and metastatic events, tumor size was associated with an independent risk for developing metastases. No independent factor for suffering local recurrence could be identified.

Discussion
Omission of chemotherapy in a non-stratified way seems not justified. Size governs survival due to high linear association with risk of suffering metastatic recurrence in a granular classification.