bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clarification of Eosinophilic Esophagitis Treatment in the DoD Retention Standards
Authors: Gable Austin , Fiore Benjamin , Cheatham Joseph 
Published: August 2021

ABSTRACT
The DoD Instruction 6130.03, Volume 2, outlines the retention standards for the U.S. Military, providing guidance on medical conditions and treatments that are disqualifying for all branches of the military. This document states that patients with conditions requiring immunomodulating or immunosuppressant medications do not meet retention standards. Eosinophilic esophagitis is a common, chronic inflammatory disease of the esophagus that typically presents with dysphagia. Although proton pump inhibitors are effective at treating this disease in some cases, swallowed topical steroids are the most frequently used therapy within the DoD. These medications act locally in the esophagus and do not cause systemic side effects typical of oral steroid therapy, including immunosuppression. They are effective at inducing and maintaining disease remission and are generally well tolerated, with minimal side effects. We propose a brief amendment to this document to clarify the language used and avoid inappropriate Medical Evaluation Board referrals.
X-ray spectra, light curves and SEDs of blazars frequently observed by Swift
Authors: Giommi Paolo , Perri M , Capalbi M , D’Elia V , Barres de Almeida U , Brandt C H , Pollock A M T , Arneodo F , Di Giovanni A , Chang Y L , Civitarese O , De Angelis M , Leto C , Verrecchia F , Ricard N , Di Pippo S , Middei R , Penacchioni A V , Ruffini R , Sahakyan N , Israyelyan D , Turriziani S 
Published: August 2021

ABSTRACT
Blazars research is one of the hot topics of contemporary extragalactic astrophysics. That is because these sources are the most abundant type of extragalactic γ-ray sources and are suspected to play a central role in multimessenger astrophysics. We have used Swift$\_$xrtproc, a tool to carry out an accurate spectral and photometric analysis of the Swift-XRT data of all blazars observed by Swift at least 50 times between December 2004 and the end of 2020. We present a database of X-ray spectra, best-fit parameter values, count rates and flux estimations in several energy bands of over 31 000 X-ray observations and single snapshots of 65 blazars. The results of the X-ray analysis have been combined with other multifrequency archival data to assemble the broad-band Spectral Energy Distributions (SEDs) and the long-term light curves of all sources in the sample. Our study shows that large X-ray luminosity variability on different time-scales is present in all objects. Spectral changes are also frequently observed with a ‘harder-when-brighter’ or ‘softer-when-brighter’ behaviour depending on the SED type of the blazars. The peak energy of the synchrotron component (νpeak) in the SED of HBL blazars, estimated from the log-parabolic shape of their X-ray spectra, also exhibits very large changes in the same source, spanning a range of over two orders of magnitude in Mrk421 and Mrk501, the objects with the best data sets in our sample.
Primordial obliquities of brown dwarfs and super-Jupiters from fragmenting gravito-turbulent discs
Authors: Jennings R Michael , Chiang Eugene 
Published: August 2021

ABSTRACT
Super-Jupiters, brown dwarfs, and stars can form from the collapse of self-gravitating discs. Such discs are turbulent, with flocculent spiral arms accelerating gas to transonic speeds horizontally and vertically. Objects that fragment from gravito-turbulent discs should spin with a wide range of directions, reflecting the random orientations of their parent eddies. We show by direct numerical simulation that obliquities of newly collapsed fragments can range up to 45○. Subsequent collisions between fragments can further alter the obliquity distribution, up to 90○ or down to near-zero. The large obliquities of newly discovered super-Jupiters on wide orbits around young stars may be gravito-turbulent in origin. Obliquely spinning fragments are born on orbits that may be inclined relative to their parent discs by up to 20○, and gravitationally stir leftover material to many times the pre-fragmentation disc thickness.
SDSS J154751.94+025550 with double-peaked broad H β but single-peaked broad H α: a candidate for central binary black hole system?
Authors: Zhang XueGuang 
Published: August 2021

ABSTRACT
In this manuscript, an interesting blue active galactic nuclei (AGNs) SDSS J154751.94+025550 (=SDSS J1547) is reported with very different line profiles of broad Balmer emission lines: double-peaked broad H β but single-peaked broad H α. SDSS J1547 is the first AGN with detailed discussions on very different line profiles of the broad Balmer emission lines, besides the simply mentioned different broad lines in the candidate for a binary black hole (BBH) system in SDSS J0159+0105. The very different line profiles of the broad Balmer emission lines can be well explained by different physical conditions to two central BLRs in a central BBH system in SDSS J1547. Furthermore, the long-term light curve from CSS can be well described by a sinusoidal function with a periodicity about 2159 d, providing further evidence to support the expected central BBH system in SDSS J1547. Therefore, it is interesting to treat different line profiles of broad Balmer emission lines as intrinsic indicators of central BBH systems in broad line AGN. Under assumptions of BBH systems, 0.125 per cent of broad-line AGN can be expected to have very different line profiles of broad Balmer emission lines. Future study on more broad line AGN with very different line profiles of broad Balmer emission lines could provide further clues on the different line profiles of broad Balmer emission lines as indicator of BBH systems.
The thermalization of massive galaxy clusters
Authors: Sereno Mauro , Lovisari Lorenzo , Cui Weiguang , Schellenberger Gerrit 
Published: August 2021

ABSTRACT
In the hierarchical scenario of structure formation, galaxy clusters are the ultimate virialized products in mass and time. Hot baryons in the intracluster medium (ICM) and cold baryons in galaxies inhabit a dark matter dominated halo. Internal processes, accretion, and mergers can perturb the equilibrium, which is established only at later times. However, the cosmic time when thermalization is effective is still to be assessed. Here, we show that massive clusters in the observed universe attained an advanced thermal equilibrium ∼1.8 Gyr ago, at redshift z = 0.14 ± 0.06, when the universe was 11.7 ± 0.7 Gyr old. Hot gas is mostly thermalized after the time when cosmic densities of matter and dark energy match. We find in a statistically nearly complete and homogeneous sample of 120 clusters from the Planck Early Sunyaev-Zel’dovich (ESZ) sample that the kinetic energy traced by the galaxy velocity dispersion is a faithful probe of the gravitational energy since a look back time of at least ∼5.4 Gyr, whereas the efficiency of hot gas in converting kinetic to thermal energy, as measured through X-ray observations in the core-excised area within r500, steadily increases with time. The evolution is detected at the ∼98 per cent probability level. Our results demonstrate that halo mass accretion history plays a larger role for cluster thermal equilibrium than radiative physics. The evolution of hot gas is strictly connected to the cosmic structure formation.
The abundance of satellites around Milky Way- and M31-like galaxies with the TNG50 simulation: a matter of diversity
Authors: Engler Christoph , Pillepich Annalisa , Pasquali Anna , Nelson Dylan , Rodriguez-Gomez Vicente , Chua Kun Ting Eddie , Grebel Eva K , Springel Volker , Marinacci Federico , Weinberger Rainer , Vogelsberger Mark , Hernquist Lars 
Published: August 2021

ABSTRACT
We study the abundance of satellite galaxies around 198 Milky Way- (MW) and M31-like hosts in TNG50, the final installment in the IllustrisTNG suite of cosmological magnetohydrodynamical simulations. MW/M31-like analogues are defined as discy galaxies with stellar masses of $M_* = 10^{10.5 - 11.2}~\rm {M}_\odot$ in relative isolation at z = 0. By defining satellites as galaxies with $M_* \ge 5\times 10^{6}~\rm {M}_\odot$ within $300~\rm {kpc}$ (3D) of their host, we find a remarkable level of diversity and host-to-host scatter across individual host galaxies. The median TNG50 MW/M31-like galaxy hosts a total of $5^{+6}_{-3}$ satellites with $M_* \ge 8 \times 10^6~\rm {M}_\odot$, reaching up to $M_* \sim 10^{8.5^{+0.9}_{-1.1}}~\rm {M}_\odot$. Even at a fixed host halo mass of $10^{12}~\rm {M}_\odot$, the total number of satellites ranges between 0 and 11. The abundance of subhaloes with $M_\rm {dyn} \ge 5 \times 10^7~\rm {M}_\odot$ is larger by a factor of more than 10. The number of all satellites (subhaloes) ever accreted is larger by a factor of 4–5 (3–5) than those surviving to z = 0. Hosts with larger galaxy stellar mass, brighter K-band luminosity, more recent halo assembly, and – most significantly – larger total halo mass typically have a larger number of surviving satellites. The satellite abundances around TNG50 MW/M31-like galaxies are consistent with those of mass-matched hosts from observational surveys (e.g. SAGA) and previous simulations (e.g. Latte). While the observed MW satellite system falls within the TNG50 scatter across all stellar masses considered, M31 is slightly more satellite-rich than our 1σ scatter but well consistent with the high-mass end of the TNG50 sample. We find a handful of systems with both a Large and a Small Magellanic Cloud-like satellite. There is no missing satellites problem according to TNG50.
Central kinematics of the Galactic globular cluster M80
Authors: Göttgens Fabian , Kamann Sebastian , Baumgardt Holger , Dreizler Stefan , Giesers Benjamin , Husser Tim-Oliver , den Brok Mark , Fétick Romain , Krajnovic Davor , Weilbacher Peter M 
Published: August 2021

ABSTRACT
We use spectra observed with the integral-field spectrograph Multi Unit Spectroscopic Explorer (MUSE) to reveal the central kinematics of the Galactic globular cluster Messier 80 (M80, NGC 6093). Using observations obtained with the recently commissioned narrow-field mode of MUSE, we are able to analyse 932 stars in the central 7.5 arcsec by 7.5 arcsec of the cluster for which no useful spectra previously existed. Mean radial velocities of individual stars derived from the spectra are compared to predictions from axisymmetric Jeans models, resulting in radial profiles of the velocity dispersion, the rotation amplitude, and the mass-to-light ratio. The new data allow us to search for an intermediate-mass black hole (IMBH) in the centre of the cluster. Our Jeans model finds two similarly probable solutions around different dynamical cluster centres. The first solution has a centre close to the photometric estimates available in the literature and does not need an IMBH to fit the observed kinematics. The second solution contains a location of the cluster centre that is offset by about 2.4 arcsec from the first one and it needs an IMBH mass of $4600^{+1700}_{-1400}~\text{M}_\odot {}$. N-body models support the existence of an IMBH in this cluster with a mass of up to 6000 M⊙ in this cluster, although models without an IMBH provide a better fit to the observed surface brightness profile. They further indicate that the cluster has lost nearly all stellar-mass black holes. We further discuss the detection of two potential high-velocity stars with radial velocities of 80–90 $\text{km}\, \text{s}^{-1}$ relative to the cluster mean.
Press–Schechter primordial black hole mass functions and their observational constraints
Authors: Sureda Joaquín , Magaña Juan , Araya Ignacio J , Padilla Nelson D 
Published: August 2021

ABSTRACT
We present a modification of the Press–Schechter (PS) formalism to derive general mass functions for primordial black holes (PBHs), considering their formation as being associated with the amplitude of linear energy density fluctuations. To accommodate a wide range of physical relations between the linear and non-linear conditions for collapse, we introduce an additional parameter to the PS mechanism, and that the collapse occurs at either a given cosmic time, or as fluctuations enter the horizon. We study the case where fluctuations obey Gaussian statistics and follow a primordial power spectrum of broken power-law form with a blue spectral index for small scales. We use the observed abundance of supermassive black holes (SMBH) to constrain the extended mass functions taking into account dynamical friction. We further constrain the modified PS by developing a method for converting existing constraints on the PBH mass fraction, derived assuming monochromatic mass distributions for PBHs, into constraints applicable for extended PBH mass functions. We find that when considering well-established monochromatic constraints, there are regions in parameter space where all the dark matter can be made of PBHs. Of special interest is the region for the characteristic mass of the distribution ${\sim}10^2\, \mathrm{M}_\odot$, for a wide range of blue spectral indices in the scenario where PBHs form as they enter the horizon, where the linear threshold for collapse is of the order of the typical overdensities, as this is close to the black hole masses detected by LIGO, which are difficult to explain by stellar collapse.
The spatial distribution of Milky Way satellites, gaps in streams, and the nature of dark matter
Authors: Lovell Mark R , Cautun Marius , Frenk Carlos S , Hellwing Wojciech A , Newton Oliver 
Published: August 2021

ABSTRACT
The spatial distribution of Milky Way (MW) subhaloes provides an important set of observables for testing cosmological models. These include the radial distribution of luminous satellites, planar configurations, and the abundance of dark subhaloes whose existence or absence is key to distinguishing among dark matter models. We use the cocoN-body simulations of cold dark matter (CDM) and 3.3 keV thermal relic warm dark matter (WDM) to predict the satellite spatial distribution in the limit that the impact of baryonic physics is minimal. We demonstrate that the radial distributions of CDM and 3.3 keV-WDM luminous satellites are identical if the minimum pre-infall halo mass to form a galaxy is &gt;108.5 ${\, \rm M_\odot }$. The distribution of dark subhaloes is significantly more concentrated in WDM due to the absence of low mass, recently accreted substructures that typically inhabit the outer parts of a MW halo in CDM. We show that subhaloes of mass [107, 108] ${\, \rm M_\odot }$ and within 30 kpc of the centre are the stripped remnants of larger haloes in both models. Therefore, their abundance in WDM is 3× higher than one would anticipate from the overall WDM subhalo population. We estimate that differences between CDM and WDM concentration–mass relations can be probed for subhalo–stream impact parameters &lt;2 kpc. Finally, we find that the impact of WDM on planes of satellites is likely negligible. Comprehensive comparisons with observations will require further work with high resolution, self-consistent hydrodynamical simulations.
How well is angular momentum accretion modelled in semi-analytic galaxy formation models?
Authors: Hou Jun , Lacey Cedric G , Frenk Carlos S 
Published: August 2021

ABSTRACT
Gas cooling and accretion in haloes delivers mass and angular momentum on to galaxies. In this work, we investigate the accuracy of the modelling of this important process in several different semi-analytic (SA) galaxy formation models (galform, l-galaxies, and morgana) through comparisons with a hydrodynamical simulation performed with the moving-mesh code arepo. Both SA models and the simulation were run without any feedback or metal enrichment, in order to focus on the cooling and accretion process. All of the SA models considered here assume that gas cools from a spherical halo. We found that the assumption that the gas conserves its angular momentum when moving from the virial radius, rvir, to the central region of the halo, r ∼ 0.1rvir, is approximately consistent with the results from our simulation. We also found that, compared to the simulation, the morgana model tends to overestimate the mean specific angular momentum of cooled-down gas, the l-galaxies model also tends to overestimate this in low-redshift massive haloes, while the two older galform models tend to underestimate the angular momentum. In general, the predictions of the new galform cooling model developed by Hou et al. agree the best with the simulation.
Expanded access use of rezafungin for salvage therapy of invasive Candida glabrata infection: A case report
Authors: Adeel Alina , Qu Ming D , Siddiqui Efaza , Levitz Stuart M , Ellison Richard T 
Published: August 2021

Abstract
Rezafungin is a semi-synthetic, long acting echinocandin with broad spectrum activity against many Candida species (spp)., and Aspergillus spp., including subset of drug-resistant strains. It is currently in phase III trials and was found to be safe and effective for treatment of candidemia and/or invasive Candida infections in a phase II trial. However, there are no long-term safety or efficacy data. We report on the successful ongoing compassionate use of rezafungin obtained through expanded access for over one year in a patient with a multidrug-resistant Candida glabrata mediastinal infection from a vascular graft infection and retained foreign material.
Repurposable drugs for SARS-CoV-2 and influenza sepsis with scRNA-seq data targeting post-transcription modifications
Authors: Wang Zhihan , Guo Kai , Gao Pan , Pu Qinqin , Li Changlong , Hur Junguk , Wu Min 
Published: August 2021

Abstract
Coronavirus disease 2019 (COVID-19) has impacted almost every part of human life worldwide, posing a massive threat to human health. The lack of time for new drug discovery and the urgent need for rapid disease control to reduce mortality have led to a search for quick and effective alternatives to novel therapeutics, for example drug repurposing. To identify potentially repurposable drugs, we employed a systematic approach to mine candidates from U.S. FDA-approved drugs and preclinical small-molecule compounds by integrating gene expression perturbation data for chemicals from the Library of Integrated Network-Based Cellular Signatures project with a publicly available single-cell RNA sequencing dataset from patients with mild and severe COVID-19 (GEO: GSE145926, public data available and accessed on 22 April 2020). We identified 281 FDA-approved drugs that have the potential to be effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, 16 of which are currently undergoing clinical trials to evaluate their efficacy against COVID-19. We experimentally tested and demonstrated the inhibitory effects of tyrphostin-AG-1478 and brefeldin-a, two chemical inhibitors of glycosylation (a post-translational modification) on the replication of the single-stranded ribonucleic acid (ssRNA) virus influenza A virus as well as on the transcription and translation of host cell cytokines and their regulators (IFNs and ISGs). In conclusion, we have identified and experimentally validated repurposable anti-SARS-CoV-2 and IAV drugs using a systems biology approach, which may have the potential for treating these viral infections and their complications (sepsis).
Inhibitory activity of medicinal mushroom Ganoderma lucidum on colorectal cancer by attenuating inflammation
Authors: Liu Mandy M , Liu Tiantian , Yeung Steven , Wang Zhijun , Andresen Bradley , Parsa Cyrus , Orlando Robert , Zhou Bingsen , Wu Wei , Li Xia , Zhang Yilong , Wang Charles , Huang Ying 
Published: August 2021

Abstract
The medicinal mushroom Ganoderma lucidum (GL, Reishi or Lingzhi) exhibits an inhibitory effect on cancers. However, the underlying mechanism of the antitumor activity of GL is not fully understood. In this study, we characterized the gene networks regulated by a commercial product of GL containing a mixture of spores and fruiting bodies namely “GLSF”, in colorectal carcinoma. We found that in vitro co-administration of GLSF extract at non-toxic concentrations significantly potentiated growth inhibition and apoptosis induced by paclitaxel in CT26 and HCT-15 cells. GLSF inhibited NF-κB promoter activity in HEK-293 cells but did not affect the function of P-glycoprotein in K562/DOX cells. Furthermore, we found that when mice were fed a modified diet containing GLSF for 1 month prior to the CT26 tumor cell inoculation, GLSF alone or combined with Nab-paclitaxel markedly suppressed tumor growth and induced apoptosis. RNA-seq analysis of tumor tissues derived from GLSF-treated mice identified 53 differentially expressed genes compared to normal tissues. Many of the GLSF-down-regulated genes were involved in NF-κB-regulated inflammation pathways, such as IL-1β, IL-11 and Cox-2. Pathway enrichment analysis suggested that several inflammatory pathways involving leukocyte migration and adhesion were most affected by the treatment. Upstream analysis predicted activation of multiple tumor suppressors such as α-catenin and TP53 and inhibition of critical inflammatory mediators. “Cancer” was the major significantly inhibited biological effect of GLSF treatment. These results demonstrate that GLSF can improve the therapeutic outcome for colorectal cancer through a mechanism involving suppression of NF-κB-regulated inflammation and carcinogenesis.
Metabolic Pathways forS-Metolachlor Detoxification Differ Between Tolerant Corn and Multiple-Resistant Waterhemp
Authors: Strom Seth A , Hager Aaron G , Concepcion Jeanaflor Crystal T , Seiter Nicholas J , Davis Adam S , Morris James A , Kaundun Shiv S , Riechers Dean E 
Published: August 2021

AbstractHerbicide resistance in weeds can be conferred by target-site and/or non-target-site mechanisms, such as rapid metabolic detoxification. Resistance to the very-long-chain fatty acid–inhibiting herbicide, S-metolachlor, in multiple herbicide-resistant populations (CHR and SIR) of waterhemp (Amaranthus tuberculatus) is conferred by rapid metabolism compared with sensitive populations. However, enzymatic pathways for S-metolachlor metabolism in waterhemp are unknown. Enzyme assays using S-metolachlor were developed to determine the specific activities of glutathione S-transferases (GSTs) and cytochrome P450 monooxygenases (P450s) from CHR and SIR seedlings to compare with tolerant corn and sensitive waterhemp (WUS). GST activities were greater (∼2-fold) in CHR and SIR compared to WUS but much less than corn. In contrast, P450s in microsomal extracts from CHR and SIR formed O-demethylated S-metolachlor, and their NADPH-dependent specific activities were greater (&gt;20-fold) than corn or WUS. Metabolite profiles of S-metolachlor generated via untargeted and targeted liquid chromatography–mass spectrometry from CHR and SIR differed from WUS, with greater relative abundances of O-demethylated S-metolachlor and O-demethylated S-metolachlor-glutathione conjugates formed by CHR and SIR. In summary, our results demonstrate that S-metolachlor metabolism in resistant waterhemp involves Phase I and Phase II metabolic activities acting in concert, but the initial O-demethylation reaction confers resistance.