bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of electronic PROMs provides same outcomes as paper version in a spine surgery registry. Results from a prospective cohort study
Authors: Langella Francesco , Barletta Paolo , Baroncini Alice , Agarossi Matteo , Scaramuzzo Laura , Luca Andrea , Bassani Roberto , Peretti Giuseppe M. , Lamartina Claudio , Villafañe Jorge H. , Berjano Pedro 
Published: May 2021

Abstract
Background and Purpose
Patient-Reported Measured Outcomes (PROMs) are essential to gain a full understanding of a patient’s condition, and in spine surgery, these questionnaires are of help when tailoring a surgical strategy. Electronic registries allow for a systematic collection and storage of PROMs, making them readily available for clinical and research purposes. This study aimed to investigate the reliability between the electronic and paper form of ODI (Oswestry Disability Index), SF-36 (Short Form Health Survey 36) and COMI-back (Core Outcome Measures Index for the back) questionnaires.

Methods
A prospective analysis was performed of ODI, SF-36 and COMI-back questionnaires collected in paper and electronic format in two patients’ groups: Pre-Operatively (PO) or at follow-up (FU). All patients, in both groups, completed the three questionnaires in paper and electronic form. The correlation between both methods was assessed with the Intraclass Correlation Coefficients (ICC).

Results
The data from 100 non-consecutive, volunteer patients with a mean age of 55.6 ± 15.0 years were analysed. For all of the three PROMs, the reliability between paper and electronic questionnaires results was excellent (ICC: ODI = 0.96; COMI = 0.98; SF36-MCS = 0.98; SF36-PCS = 0.98. For all p < 0.001).

Conclusions
This study proved an excellent reliability between the electronic and paper versions of ODI, SF-36 and COMI-back questionnaires collected using a spine registry. This validation paves the way for stronger widespread use of electronic PROMs. They offer numerous advantages in terms of accessibility, storage, and data analysis compared to paper questionnaires.
Oceanic islands and climate: using a multi-criteria model of drivers of change to select key conservation areas in Galapagos
Authors: Escobar-Camacho Daniel , Rosero Paulina , Castrejón Mauricio , Mena Carlos F. , Cuesta Francisco 
Published: May 2021

AbstractThe unique marine and terrestrial ecosystems of the Galapagos Islands are highly vulnerable to human-based drivers of change, including the introduction of invasive species, unsustainable tourism, illegal fishing, overexploitation of ecosystem services, and climate change. These drivers can interact with climate-based drivers such as El Niño-Southern Oscillation (ENSO) at multiple temporal and spatial scales, exacerbating their negative impacts on already fragile ecosystems and the socioeconomic system of the Archipelago. In this review, we performed a literature review based on published literature from 1945 to 2020 and local and global climate databases to analyze drivers of change in the Galapagos. We developed and applied a spatial impact assessment model to identify high-ecological value areas with high sensitivity and exposure scores to environmental change drivers. We identified 13 priority HEVA that encompass ca. 23% (14,715 km2) of the Galapagos Archipelago, distributed in nearly 3% of the Galapagos Marine Reserve and 20% Galapagos National Park. Current and future impacts are likely to concentrate on the inhabited islands’ highlands, whereas marine impacts concentrate along most of the Galapagos Islands’ shorelines. These results are important for guiding the design and implementation of adaptation measures aimed at increasing ecosystem resilience and human adaptive capacity in the face of global environmental change. Overall, these results will be valuable in their application for preserving Galapagos biota, securing the provision of vital ecosystem services for resident human populations, and sustaining the nature-based tourism industry.
Tyrophagus putrescentiae (Sarcoptiformes: Acaridae) in the in vitro cultures of slime molds (Mycetozoa): accident, contamination, or interaction?
Authors: Michalczyk-Wetula Dominika , Jakubowska Monika , Felska Magdalena , Skarżyński Dariusz , Mąkol Joanna , Płonka Przemysław M. 
Published: May 2021

AbstractTyrophagus putrescentiae(Schrank), commonly known as the cereal mite, cheese mite, or ham mite, is a cosmopolitan species reported from various environments in the wild, including soil, plant material and vertebrate nests. It has also been recognized as a common pest of food storages, mycological collections as well as plant and invertebrate laboratory cultures. Laboratory observations indicate thatT. putrescentiaefeeds on a large range of dermatophytes, yeasts and molds. We have observed the interspecific relation between this mite and several species of true slime molds (Mycetozoa) under laboratory conditions, which confirms the very broad spectrum of feeding habits ofT. putrescentiae. Mycetozoans were grown in semi-sterile in vitro cultures and fed with oat flour or oat flakes.Tyrophagus putrescentiaedisplayed affinity to all macroscopically identifiable stages of the life cycle ofFuligo septica(L.) F.H. Wigg,Physarum polycephalumSchwein and theDidymiumsp. complex [Didymium iridis(Ditmar) Fr.,Didymium nigripes(Link) Fr. andDidymium bahienseGottsb.]: live, decaying or dead plasmodia, sporangia, aethalia, spores and sclerotia. The relation carrying symptoms of various types of interspecific interaction, is hypothesized to form an evolutionarily young phenomenon, which not only identifies a new aspect of mycetozoal biology, but also presents the cereal mite as a species of high adaptive potential.
A Randomised Comparison of Values and Goals, Versus Goals Only and Control, for High Nonclinical Paranoia
Authors: Davies M. , Ellett L. , Kingston J. 
Published: May 2021

Abstract
Background
Paranoia is common in the general population. Focusing on values and enhancing value-based acts may attenuate it. This study compared three brief (30-min, self-directed) online conditions: focusing on values and value-based goal setting (n = 30), goal setting only (n = 32) and non-values/goals control (n = 32) in a high paranoia sample.

Methods
Participants were randomly assigned to condition. State paranoia (primary outcome) and positive and negative self-views following a difficult interpersonal experience (secondary outcome) were assessed at baseline and two-weeks.

Results
Intention-to-treat: state paranoia was significantly lower following the values condition as compared to non-values/goals control (ηp2 = .148) and goals only (ηp2 = .072). Only the former comparison was significant. Per-protocol: groups did not significantly differ (p = .077). Within-group effect sizes: values and value-based goal setting (intention-to-treat d = .82, per-protocol d = .78), goals only (intention-to-treat d = .41, per-protocol d = .42) non-values/goals control (intention-to-treat d = .25, per-protocol d = .24). Positive self-views increased in all conditions. The increase was largest for the values condition, but not significantly so.

Limitations
Reliance on self-report, brief follow-up, predominantly White female sample.

Conclusions
The values condition was most effective at reducing non-clinical paranoia. The values condition appeared to increase positive self-views more so than comparison groups, but the sample was small and the difference was non-significant.
Creative reconstruction: a structured literature review of the early empirical research on the COVID-19 crisis and entrepreneurship
Authors: Kuckertz Andreas , Brändle Leif 
Published: May 2021

AbstractThe COVID-19 crisis triggered by the novel coronavirus (SARS-CoV-2) and the infection control measures taken have extended beyond affecting health issues to impact economic activity worldwide. In this structured literature review, the focus is specifically on how the crisis has impacted entrepreneurial activity. The review focuses on the early empirical literature that primarily relied on data collected during the first wave of the pandemic. These empirical results are synthesized in a thematic literature review. The entrepreneurship research on the COVID-19 crisis is marked by three perspectives: the uncertainty perspective, the resilience perspective, and the opportunity perspective. To obtain a complete picture of the effects of the crisis on entrepreneurship, these three perspectives should be considered in combination. We provide implications for future research, policymakers, and entrepreneurs discussing how the interplay of the reviewed perspectives provides paths toward creative reconstruction, that is, the opportunity to move beyond pre-crisis levels of innovation and entrepreneurial action.
Uptake and bio-transformation of telmisartan by cress (Lepidium sativum) from sewage treatment plant effluents using high-performance liquid chromatography/drift-tube ion-mobility quadrupole time-of-flight mass spectrometry
Authors: Lang Tamara , Himmelsbach Markus , Mlynek Franz , Buchberger Wolfgang , Klampfl Christian W. 
Published: May 2021

AbstractIn the present study, the uptake and metabolization of the sartan drug telmisartan by a series of plants was investigated. Thereby for seven potential metabolites, modifications on the telmisartan molecule such as hydroxylation and/or glycosylation could be tentatively identified. For two additional signals detected at accurate masses m/z 777.3107 and m/z 793.3096, no suggestions for molecular formulas could be made. Further investigations employing garden cress (Lepidium sativum) as a model plant were conducted. This was done in order to develop an analytical method allowing the detection of these substances also under environmentally relevant conditions. For this reason, the knowledge achieved from treatment of the plants with rather high concentrations of the parent drug (10 mg L−1) was compared with results obtained when using solutions containing telmisartan in the μg - ng L−1 range. Thereby the parent drug and up to three tentative drug-related metabolites could still be detected. Finally cress was cultivated in water taken from a local waste water treatment plant effluent containing 90 ng L−1 of telmisartan and harvested and the cress roots were extracted. In this extract, next to the parent drug one major metabolite, namely telmisartan-glucose could be identified.
Man’s best friend in life and death: scientific perspectives and challenges of dog brain banking
Authors: Sándor Sára , Czeibert Kálmán , Salamon Attila , Kubinyi Enikő 
Published: May 2021

AbstractBiobanking refers to the systematic collection, storage, and distribution of pre- or post-mortem biological samples derived from volunteer donors. The demand for high-quality human specimens is clearly demonstrated by the number of newly emerging biobanking facilities and large international collaborative networks. Several animal species are relevant today in medical research; therefore, similar initiatives in comparative physiology could be fruitful. Dogs, in particular, are gaining increasing attention in translational research on complex phenomena, like aging, cancer, and neurodegenerative diseases. Therefore, biobanks gathering and storing dog biological materials together with related data could play a vital role in translational and veterinary research projects. To achieve these aims, a canine biobank should meet the same standards in sample quality and data management as human biobanks and should rely on well-designed collaborative networks between different professionals and dog owners. While efforts to create dog biobanks could face similar financial and technical challenges as their human counterparts, they can widen the spectrum of successful collaborative initiatives towards a better picture of dogs’ physiology, disease, evolution, and translational potential. In this review, we provide an overview about the current state of dog biobanking and introduce the “Canine Brain and Tissue Bank” (CBTB)—a new, large-scale collaborative endeavor in the field.
Oxide Evolution During the Solidification of 316L Stainless Steel from Additive Manufacturing Powders with Different Oxygen Contents
Authors: Yang Xinliang , Tang Fengzai , Hao Xinjiang , Li Zushu 
Published: May 2021

Abstract
The oxide evolution during the solidification of 316L stainless steel from additive manufacturing powders with different oxygen contents is studied by in situ observation of the melting and solidification of the powder materials, advanced characterization of the solidified materials, and non-equilibrium thermodynamic analysis. An oxide evolution map is established for the 316L powders with different oxygen contents. It reveals the relationship between the surface oxidation in the reused powder and its expected oxide species and morphology in the as-solidified component. For the 316L powder with oxygen content higher than ~ 0.039 pct, the liquid oxide formed first from the steel melt and then crystallized to certain oxide phases during solidification, while for the powder with lower oxygen, oxide phases are suggested to directly form from the steel melt. The oxide species in the as-solidified sample was predicted by the Scheil–Gulliver cooling calculation and verified by the TEM-based phase identification. The oxides formed in the melt of low O 316L alloy (0.0355 pct O) are predicted to be (Mn, Cr)Cr2O4 spinel and SiO2 oxide. In the high O (0.4814 pct O) 316L melt solidification, the final oxides formed are (Mn, Cr)Cr2O4 spinel, SiO2 oxide, and Cr2O3 corundum. As an important characteristic of powder materials, the oxygen pick-up due to the powder surface oxidation significantly influences the inclusion evolution in the powder fusion process.
Natural Quinone Dyes: A Review on Structure, Extraction Techniques, Analysis and Application Potential
Authors: Dulo Benson , Phan Kim , Githaiga John , Raes Katleen , De Meester Steven 
Published: May 2021

AbstractSynthetic dyes are by far the most widely applied colourants in industry. However, environmental and sustainability considerations have led to an increasing efforts to substitute them with safer and more sustainable equivalents. One promising class of alternatives is the natural quinones; these are class of cyclic organic compounds characterized by a saturated (C6) ring that contains two oxygen atoms that are bonded to carbonyls and have sufficient conjugation to show color. Therefore, this study looks at the potential of isolating and applying quinone dye molecules from a sustainable source as a possible replacement for synthetic dyes. It presents an in-depth description of the three main classes of quinoid compounds in terms of their structure, occurrence biogenesis and toxicology. Extraction and purification strategies, as well as analytical methods, are then discussed. Finally, current dyeing applications are summarised. The literature review shows that natural quinone dye compounds are ubiquitous, albeit in moderate quantities, but all have a possibility of enhanced production. They also display better dyeability, stability, brightness and fastness compared to other alternative natural dyes, such as anthocyanins and carotenoids. Furthermore, they are safer for the environment than are many synthetic counterparts. Their extraction, purification and analysis are simple and fast, making them potential substitutes for their synthetic equivalents.
Graphic Abstract
Decontamination of cadmium(II) from synthetic wastewater onto shea fruit shell biomass
Authors: Bayuo Jonas 
Published: May 2021

AbstractShea fruit shells being an agricultural waste material was utilized to test its novelty as an inexpensive biosorbent for the elimination of Cd(II) from synthetic wastewater using the batch method. A batch study was employed to probe the impact of pH of the solution, contact time, temperature and initial concentration on the depollution of Cd(II) ions using unmodified Shea fruit shells biomass. The decontamination of Cd(II) by the unmodified Shea fruit shells biomass was found to be dependent on these adsorption parameters. The equilibrium data best represented Freundlich isotherm by a correlation coefficient (R2) of 0.9691. The kinetic models analyzed suggest pseudo-second-order ($${R}^{2} = 0.9515$$

R

2

=
0.9515

) as the best fit model signifying that the removal of Cd(II) ions was on account of chemisorption. The positive values of the thermodynamic parameters, ΔH° and ΔS° reveal endothermic and increase of disorder of the process while the negative charge of ΔG° shows spontaneity of the system.
Dynamic Quantum Games
Authors: Kolokoltsov Vassili N. 
Published: May 2021

AbstractQuantum games represent the really twenty-first century branch of game theory, tightly linked to the modern development of quantum computing and quantum technologies. The main accent in these developments so far was made on stationary or repeated games. In this paper, we aim at initiating the truly dynamic theory with strategies chosen by players in real time. Since direct continuous observations are known to destroy quantum evolutions (so-called quantum Zeno paradox), the necessary new ingredient for quantum dynamic games must be the theory of non-direct observations and the corresponding quantum filtering. Apart from the technical problems in organizing feedback quantum control in real time, the difficulty in applying this theory for obtaining mathematically amenable control systems is due partially to the fact that it leads usually to rather non-trivial jump-type Markov processes and/or degenerate diffusions on manifolds, for which the corresponding control is very difficult to handle. The starting point for the present research is the remarkable discovery (quite unexpected, at least to the author) that there exists a very natural class of homodyne detections such that the diffusion processes on projective spaces resulting by filtering under such arrangements coincide exactly with the standard Brownian motions (BM) on these spaces. In some cases, one can even reduce the process to the plain BM on Euclidean spaces or tori. The theory of such motions is well studied making it possible to develop a tractable theory of related control and games, which can be at the same time practically implemented on quantum optical devices.
Abstracts voorjaarsvergadering NVU, 21 mei 2021
Authors:   Bohn Stafleu van Loghum
Published: May 2021

SamenvattingDe EAU-richtlijn adviseert om geen confirmatory prostaatbiopten tijdens active surveillance te verrichten bij patiënten die gediagnosticeerd zijn met een upfront MRI (strength rating: weak). In deze studie analyseren we de uitkomst van confirmatory biopten om te bepalen wie wel of niet gebaat is bij dit type biopten.
Self-sampling versus health care professional-guided swab collection for SARS-CoV-2 testing
Authors: Würstle Silvia , Spinner Christoph D. , Voit Florian , Hoffmann Dieter , Hering Svenja , Weidlich Simon , Schneider Jochen , Zink Alexander , Treiber Matthias , Iakoubov Roman , Schmid Roland M. , Protzer Ulrike , Erber Johanna 
Published: May 2021

Abstract
Purpose
To evaluate the diagnostic reliability and practicability of self-collected oropharyngeal swab samples for the detection of SARS-CoV-2 infection as self-sampling could enable broader testing availability and reduce both personal protective equipment and potential exposure.

Methods
Hospitalized SARS-CoV-2-infected patients were asked to collect two oropharyngeal swabs (SC-OPS1/2), and an additional oropharyngeal swab was collected by a health care professional (HCP-OPS). SARS-CoV-2 PCR testing for samples from 58 participants was performed, with a 48-h delay in half of the self-collected samples (SC-OPS2). The sensitivity, probability of concordance, and interrater reliability were calculated. Univariate and multivariate analyses were performed to assess predictive factors. Practicability was evaluated through a questionnaire.

Results
The test sensitivity for HCP-OPS, SC-OPS1, and SC-OPS2 was 88%, 78%, and 77%, respectively. Combining both SC-OPS results increased the estimated sensitivity to 88%. The concordance probability between HCP-OPS and SC-OPS1 was 77.6% and 82.5% between SC-OPS1 and SC-OPS2, respectively. Of the participants, 69% affirmed performing future self-sampling at home, and 34% preferred self-sampling over HCP-guided testing. Participants with both positive HCP-OPS1 and SC-OPS1 indicating no challenges during self-sampling had more differences in viral load levels between HCP-OPS1 and SC-OPS1 than those who indicated challenges. Increasing disease duration and the presence of anti-SARS-CoV-2-IgG correlated with negative test results in self-collected samples of previously confirmed SARS-CoV-2 positive individuals.

Conclusion
Oropharyngeal self-sampling is an applicable testing approach for SARS-CoV-2 diagnostics. Self-sampling tends to be more effective in early versus late infection and symptom onset, and the collection of two distinct samples is recommended to maintain high test sensitivity.
Testing telediagnostic thyroid ultrasound in Peru: a new horizon in expanding access to imaging in rural and underserved areas
Authors: Marini T. J. , Weiss S. L. , Gupta A. , Zhao Y. T. , Baran T. M. , Garra B. , Shafiq I. , Oppenheimer D. C. , Egoavil M. S. , Ortega R. L. , Quinn R. A. , Kan J. , Dozier A. M. , Tamayo L. , Carlotto C. , Castaneda B. 
Published: May 2021

AbstractPurposeThyroid ultrasound is a key tool in the evaluation of the thyroid, but billions of people around the world lack access to ultrasound imaging. In this study, we tested an asynchronous telediagnostic ultrasound system operated by individuals without prior ultrasound training which may be used to effectively evaluate the thyroid and improve access to imaging worldwide.MethodsThe telediagnostic system in this study utilizes volume sweep imaging (VSI), an imaging technique in which the operator scans the target region with simple sweeps of the ultrasound probe based on external body landmarks. Sweeps are recorded and saved as video clips for later interpretation by an expert. Two operators without prior ultrasound experience underwent 8 h of training on the thyroid VSI protocol and the operation of the telemedicine platform. After training, the operators scanned patients at a health center in Lima. Telediagnostic examinations were sent to the United States for remote interpretation. Standard of care thyroid ultrasound was performed by an experienced radiologist at the time of VSI examination to serve as a reference standard.ResultsNovice operators scanned 121 subjects with the thyroid VSI protocol. Of these exams, 88% were rated of excellent image quality showing complete or near complete thyroid visualization. There was 98.3% agreement on thyroid nodule presence between VSI teleultrasound and standard of care ultrasound (Cohen’s kappa 0.91,P < 0.0001). VSI measured the thyroid size, on average, within 5 mm compared to standard of care. Readers of VSI were also able to effectively characterize thyroid nodules, and there was no significant difference in measurement of thyroid nodule size (P = 0.74) between VSI and standard of care.ConclusionThyroid VSI telediagnostic ultrasound demonstrated both excellent visualization of the thyroid gland and agreement with standard of care thyroid ultrasound for nodules and thyroid size evaluation. This system could be deployed for evaluation of palpable thyroid abnormalities, nodule follow-up, and epidemiological studies to promote global health and improve the availability of diagnostic imaging in underserved communities.