bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atorvastatin Enhances Inhibitory Effects of Irradiation on Tumor Growth by Reducing
MSH2 Expression Both in Prostate Cancer Cells and Xenograft Tumor Models
Authors: He Zhenhua , Xu Dingkai , Shen Fuhui , Zeng Fangang , Qi Ping , Zhai Zhenxing , Wang Zhiping 
Published: June 2021

Background:
Prostate cancer (PCa) is the fourth most common tumor in males.

Objective:
This study aimed to investigate effects of atorvastatin (AS) on PCa cells proliferation and clarify the associated
mechanisms.

Methods:
PCa cell lines were cultured and treated with irradiation (IR) (4 Gy), AS (6 μg/ml), transfected with Bcl-2
siRNA, and then divided into different groups. Xenograft tumor mouse model was established. Bcl-2 and MSH2 gene
transcription and protein expression were evaluated using RT-PCR assay and western blot assay. Plate clone formation
assay was employed to examine colony formation. MTT assay was used to detect cell viabilities. Flow cytometry
analysis was utilized to verify apoptosis. Co-immunoprecipitation and immuno-fluorescence assay were used to
identify interaction between Bcl-2 and MSH2.

Results:
IR significantly reduced colony formation, enhanced Bcl-2 and reduced MSH2 gene transcription in PCa cells
compared to un-treated cells (p<0.05). AS significantly strengthened radio-therapeutic effects of IR on colony formation,
decreased cell apoptosis and increased Bcl-2 gene transcription/protein expression in PCa cells compared to single
IR treatment cells (p<0.05). AS combining IR down-regulated MSH2 gene transcription/protein expression in PCa
cells compared to single IR treatment cells (p<0.05). Bcl-2 interacted with MSH2 both in PCa cells and tumor tissues
administrating with AS. AS enhanced reductive effects of IR on tumor size of Xenograft tumor mice.

Conclusion:
Atorvastatin administration enhanced inhibitory effects of IR either on PCa cells or tumor size of
Xenograft tumor mice. The inhibitory effects of atorvastatin were mediated by reducing MSH2 expression and triggering
interaction between Bcl-2 and MSH2, both in vitro and in vivo levels.
Deteksi Permukiman Kumuh Menggunakan Informasi Spektral dan Tekstur Citra Multiresolusi Spasial (studi di sebagian Kota Yogyakarta)
Authors: Fadhilah Achmad , Widayani Prima , Hidayati Iswari Nur 
Published: June 2021

Pemetaan dan identifikasi merupakan tahap awal dalam program peningkatan kualitas permukiman kumuh. Pemetaan permukiman kumuh saat ini masih menggunakan metode survei langsung yang membutuhkan banyak biaya, waktu, dan tenaga. Penelitian ini bertujuan untuk mendeteksi keberadaan permukiman kumuh menggunakan citra satelit multiresolusi spasial sebagai metode alternatif dalam mengidentifikasi permukiman kumuh. Citra yang digunakan dalam penelitian ini antara lain: Pleiades-1B, SPOT-7, dan Sentinel-2. Studi ini berlokasi di sebagian Kota Yogyakarta yang dibagi dua daerah penelitian. Algortima Support Vector Machine (SVM) digunakan untuk mengkelaskan permukiman kumuh dan bukan kumuh. Parameter yang digunakan dalam penelitian ini antara lain: Saluran multispektral, Grey Level Co-occurrence Matrx (GLCM), dan Normalized Difference Vegetation Index (NDVI). Validasi dilakukan dengan menggabungkan data sekunder peta permukiman kumuh dan hasil observasi lapangan. Hasil penelitian menunjukkan bahwa tingkat akurasi klasifikasi tertinggi dihasilkan dari layer Sentinel-2 GLCM 3x3 sebesar 56,26% pada daerah penelitian 1, sedangkan pada daerah penelitian 2 diperoleh dari layer Pleiades-1B GLCM 9x9 sebesar 66,17%.
Perspectiva sociológica del contrabando de combustible en la frontera colombo – venezolana
Authors: González Palma Felipe 
Published: June 2021

este escrito contrasta la concepción clásica del derecho que ignora realidades para construir ficciones, como lo sostenía Marx respecto al hurto de leña, respecto de la acumulación por desposesión y bienes comunes, mostrando las dinámicas internas vinculadas a la práctica del contrabando de gasolina en la frontera colombo-venezolana. La metodología utilizada es descriptiva, desde un enfoque sociológico, en cuanto busca precisar cómo se manifiesta el fenómeno social objeto de estudio, intentando abordar sus principales características, en aras de lograr establecer una descripción del fenómeno social. Los hallazgos indican que el contrabando ilegal de combustibles se relaciona con la integración social del individuo en la sociedad fronteriza, que hacen plausible su comprensión desde una perspectiva cultural, entendida esta como constructo eminentemente social, lo cual desborda la lectura determinista que señala que la problemática social del contrabando de combustible obedece simple y llanamente a factores de orden económico o bien al abandono por parte del Estado.
Early Acceptability of a Mobile App for Contact Tracing During the COVID-19 Pandemic in France: National Web-Based Survey
Authors: Touzani Rajae , Schultz Emilien , Holmes Seth M , Vandentorren Stéphanie , Arwidson Pierre , Guillemin Francis , Rey Dominique , Rouquette Alexandra , Bouhnik Anne-Déborah , Mancini Julien 
Published: June 2021

Background
Several countries have implemented mobile apps in an attempt to trace close contacts of patients with COVID-19 and, in turn, reduce the spread of SARS-CoV-2. However, the effectiveness of this approach depends on the adherence of a large segment of the population.

Objective
The aims of this study were to evaluate the acceptability of a COVID-19 contact tracing mobile app among the French population and to investigate the barriers to its use.

Methods
The Health Literacy Survey 2019 questioned 1003 people in France during the COVID-19 pandemic on the basis of quota sampling. The survey collected sociodemographic characteristics and health literacy data, as well as information on participants’ communication with caregivers, trust in institutions, and COVID-19 knowledge and preventive behaviors. The acceptability of a mobile app for contact tracing was measured by a single question, the responses to which were grouped into three modalities: app-supporting, app-willing, and app-reluctant. Multinomial logistic regression analysis was performed to identify the factors associated with the acceptability of a mobile app during the COVID-19 pandemic.

Results
Only 19.2% (193/1003) of all participants were app-supporting, whereas half of them (504/1003, 50.3%) were reluctant. The factors associated with willingness or support toward the contact tracing app included lower financial deprivation (app-willing: adjusted odds ratio [aOR] 0.8, 95% CI 0.69-0.93; app-supporting: aOR 0.7, 95% CI 0.58-0.84) and higher perceived usefulness of using a mobile app to send completed health questionnaires to doctors (app-willing: aOR 2.3, 95% CI 1.70-3.26; app-supporting: aOR 3.1, 95% CI 2.04-4.82). Furthermore, the likelihood of supporting the mobile app increased with age over 60 years (aOR 1.9, 95% CI 1.13-3.22), trust in political representatives (aOR 2.7, 95% CI 1.72-4.23), feeling concerned about the pandemic situation (aOR 2.2, 95% CI 1.47-3.32), and knowledge about the transmission of COVID-19 (aOR 2.0, 95% CI 1.39-2.96).

Conclusions
The most socioeconomically precarious people, who are at a higher risk of SARS-CoV-2 infection, are also the most reluctant to using a contact tracing mobile app. Therefore, optimal adherence can only be effective with a targeted discourse on public health benefits to adopt such an app, which should be combined with a reduction in inequalities by acting on structural determinants.
The COVID-19 Citizen Science Study: Protocol for a Longitudinal Digital Health Cohort Study
Authors: Beatty Alexis L , Peyser Noah D , Butcher Xochitl E , Carton Thomas W , Olgin Jeffrey E , Pletcher Mark J , Marcus Gregory M 
Published: June 2021

Background
The COVID-19 pandemic has catalyzed a global public response and innovation in clinical study methods.

Objective
The COVID-19 Citizen Science study was designed to generate knowledge about participant-reported COVID-19 symptoms, behaviors, and disease occurrence.

Methods
COVID-19 Citizen Science is a longitudinal cohort study launched on March 26, 2020, on the Eureka Research Platform. This study illustrates important advances in digital clinical studies, including entirely digital study participation, targeted recruitment strategies, electronic consent, recurrent and time-updated assessments, integration with smartphone-based measurements, analytics for recruitment and engagement, connection with partner studies, novel engagement strategies such as participant-proposed questions, and feedback in the form of real-time results to participants.

Results
As of February 2021, the study has enrolled over 50,000 participants. Study enrollment and participation are ongoing. Over the lifetime of the study, an average of 59% of participants have completed at least one survey in the past 4 weeks.

Conclusions
Insights about COVID-19 symptoms, behaviors, and disease occurrence can be drawn through digital clinical studies. Continued innovation in digital clinical study methods represents the future of clinical research.

International Registered Report Identifier (IRRID)
DERR1-10.2196/28169
Utility of the ROX Index in Predicting Intubation for Patients With COVID-19–Related Hypoxemic Respiratory Failure Receiving High-Flow Nasal Therapy: Retrospective Cohort Study
Authors: Patel Maulin , Chowdhury Junad , Mills Nicole , Marron Robert , Gangemi Andrew , Dorey-Stein Zachariah , Yousef Ibraheem , Zheng Matthew , Tragesser Lauren , Giurintano Julie , Gupta Rohit , Rali Parth , D'Alonzo Gilbert , Zhao Huaqing , Patlakh Nicole , Marchetti Nathaniel , Criner Gerard , Gordon Matthew 
Published: June 2021

Background
The use of high-flow nasal therapy (HFNT) to treat COVID-19 pneumonia has been greatly debated around the world due to concerns about increased health care worker transmission and delays in invasive mechanical ventilation (IMV). Herein, we analyzed the utility of the noninvasive ROX (ratio of oxygen saturation) index to predict the need for and timing of IMV.

Objective
This study aimed to assess whether the ROX index can be a useful score to predict intubation and IMV in patients receiving HFNT as treatment for COVID-19–related hypoxemic respiratory failure.

Methods
This is a retrospective cohort analysis of 129 consecutive patients with COVID-19 admitted to Temple University Hospital in Philadelphia, PA, from March 10, 2020, to May 17, 2020. This is a single-center study conducted in designated COVID-19 units (intensive care unit and other wards) at Temple University Hospital. Patients with moderate and severe hypoxemic respiratory failure treated with HFNT were included in the study. HFNT patients were divided into two groups: HFNT only and intubation (ie, patients who progressed from HFNT to IMV). The primary outcome was the value of the ROX index in predicting the need for IMV. Secondary outcomes were mortality, rate of intubation, length of stay, and rate of nosocomial infections in a cohort treated initially with HFNT.

Results
Of the 837 patients with COVID-19, 129 met the inclusion criteria. The mean age was 60.8 (SD 13.6) years, mean BMI was 32.6 (SD 8) kg/m², 58 (45%) were female, 72 (55.8%) were African American, 40 (31%) were Hispanic, and 48 (37.2%) were nonsmokers. The mean time to intubation was 2.5 (SD 3.3) days. An ROX index value of less than 5 at HFNT initiation was suggestive of progression to IMV (odds ratio [OR] 2.137, P=.052). Any further decrease in ROX index value after HFNT initiation was predictive of intubation (OR 14.67, P<.001). Mortality was 11.2% (n=10) in the HFNT-only group versus 47.5% (n=19) in the intubation group (P<.001). Mortality and need for pulmonary vasodilators were higher in the intubation group.

Conclusions
The ROX index helps decide which patients need IMV and may limit eventual morbidity and mortality associated with the progression to IMV.
PERSEPSI MASYARAKAT PETANI KELAPA TERHADAP PENDIDIKAN TINGGI ANAK DI KECAMATAN SIBERUT BARAT, KABUPATEN KEPULAUAN MENTAWAI
Authors: Tapondhadhai A. Tisnawati , Ansofino Ansofino , Nazmi Ranti 
Published: June 2021

Education is one of social institution that has important role to enhance prestiges and human's dignities. Education helps people to build a good relation each others. Higher education usually indicate better social life. Therefore, parents have the responsibility to their children's education. Government also have responsibility to make a good system that agree with development of various fields. Coconut farming communities generally have low income, but they have good motivation to send their children to university.This study aims to know the motivation of farmers to provide a better education for their children and also some of factors that influences their successful studies. Based on this study, to get a better social life than their parents is the motivation of coconut farmers that their children get higher education. Meanwhile, the success rate of farmer's son graduated depending on the favorable situation to supporting them to learn better and also good financial supports from their families during the studiesPendidikan merupakan suatu lembaga sosial dalam membentuk individu dalam bersosialisasi untuk meningkatkan harkat martabat manusia. Pendidikan merupakan tanggung jawab masyarakat sebagai orang tua dan pemerintah, maka itu pendidikan perlu menyesuaikan dengan tuntutan pembangunan yang memerlukan berbagai jenis keterampilan dari berbagai bidang. Masyarakat petani kelapa pada umumnya memiliki penghasilan yang rendah, akan tetapi mereka memiliki motivasi yang kuat agar anak-anak mereka bisa mengecap pendidikan sampai ke Perguruan Tinggi.Penelitian ini bertujuan untuk mengetahui motivasi petani untuk memberikan pendidikan yang lebih baik untuk anaknya dan juga beberapa faktor yang mempengaruhi keberhasilan dari anak petani untuk mewujudkan cita-citanya tersebut. Berdasarkan hasil penelitian, ditemukan bahwa motivasi petani ingin anaknya mengecap pendidikan hingga perguruan tinggi adalah agar anak mereka memperoleh kehidupan yang lebih baik. Sementara itu, faktor yang mendukung keberhasilan anak petani dalam menyelesaikan pendidikan mereka di perguruan tinggi adalah situasi kondusif yang mendukung mereka untuk belajar dengan lebih baik dan juga dukungan ekonomi yang baik dari keluarga selama menempuh pendidikan.
PANDANGAN RUMAH TANGGA SASARAN (RTS) TERHADAP PELAKSANAAN DANA BERGULIR PNPM-MP DI KELURAHAN BALAI GADANG, KOTA PADANG
Authors: Elparianti Elparianti , Abbas Ardi , Elvawati Elvawati 
Published: June 2021

This article background is information about the data differences between statistically and realities in society about PNPM-MP Programe. Statistically PNPM-MP is considered good enough in the effort to reduce poverty have been able to reduce the number of target households in the Balai Gadang, but the reality in the field are still many poor people. In general view of the target households are not re-categorized as the objectives of the program provides pastures that show received a position as a party that can not accept a revolving fund, As for the efforts made by the PNPM-MP after the target households are not back to being targeted by inviting households to be targeted to training events associated with increased economic cooperation with the family and other financial institutions greater. As for the view of the target households on the implementation of the revolving fund PNPM-MP in the fight against poverty can be concluded that in general the target households provide a positive outlook for feel that the borrowing of funds on a rolling basis from PNPM-MP, especially for households sesaran the installment lending smoothly and has had previous attemptsArtikel ini dilatarbelakangi oleh adanya perbedaan informasi antara data secara statistik dengan realitas yang ada dalam masyarakat. secara statistik pelaksanaan PNPM-MP dinilai cukup baik dalam upaya menanggulangi kemiskinan telah mampu menurunkan jumlah rumah tangga sasaran (RTS) di Kelurahan Balai Gadang, namun realitasnya dilapangan masih banyak masyarakat misikin. Secara umum pandangan rumah tangga sasaran (RTS) tidak kembali terkategori sebagai sasaran pelaksanaan program yaitu RTS memberikan padangan yang menunjukkan menerima posisi sebagai pihak yang sudah tidak bisa menerima dana bergulir, adapun upaya yang dilakukan oleh pihak pelaksanaan PNPM-MP setelah RTS tidak kembali menjadi sasaran dengan mengundang RTS ke acara pelatihan yang berhubungan dengan peningkatan ekonomi keluarga dan melakukan kerjasama dengan lembaga keuangan lain yang lebih besar. Sedangkan untuk pandangan RTS terhadap pelaksanaan dana bergulir PNPM-MP dalam upaya penanggulangan kemiskinan dapat disimpulkan bahwa secara umum RTS memberikan pandangan positif karena merasa terbantu dengan adanya peminjaman dana secara bergulir dari PNPM-MP terutama bagi RTS yang angsuran peminjamannya lancar dan telah memiliki usaha sebelumnya.
EFEKTIFITAS PROGRAM KELUARGA HARAPAN (PKH) DALAM UPAYA PENGENTASAN KEMISKINAN DI NAGARI LAGAN HILIR, KAB. PESISIR SELATAN
Authors: Ekardo Apando , Firdaus Firdaus , Elfemi Nilda 
Published: June 2021

Poverty is a multidimensional problem. Characteristic poverty is low average quality of life of the population, education, health, child nutrition, and sources of drinking water. Various attempts have been made by the Indonesian government to alleviate poverty. Once of the program is Program Keluarga Harapan (PKH). This research is to describe effectiveness of the PKH in poverty reduction efforts in Nagari Lagan Hilir Punggasan. The objectives of this study is to describe the effectiveness of the PKH for poor households. The study conducted with qualitative by descriptive type. Informants selected with purposive. Data collected through observation, interview and study document. Result is PKH in Nagari Lagan Hilir Punggasan has been effective base on program objectives. On the other hand, the targeting of PKH beneficiaries for households in Nagari Lagan Hilir Punggasan is not effective. This is due to the targeting of PKH in Nagari Lagan Hilir Punggasan still not on target.Kemiskinan merupakan masalah multidimensi yang ditandai oleh rendahnya rata-rata kualitas hidup penduduk, pendidikan, kesehatan, gizi anak-anak, dan sumber air minum. Berbagai upaya telah dilakukan oleh pemerintah Indonesia untuk mengentaskan kemiskinan. Salah satunya adalah Program Keluarga Harapan (PKH). Penelitian ini bertujaun untuk mendeskripsikan efektivitas Program Keluarga Harapan (PKH) dalam upaya pengentasan kemiskinan di Nagari Lagan Hilir Punggasan. Tujuan yang ingin dicapai dalam penelitian ini adalah mendeskripsikan efektivitas PKH bagi rumah tangga miskin. Penelitian dilakukan dengan kualitatif tipe deskriptif. Informan dipilih secara purposive. Data dikumpulkan melalui observasi, wawancara, dan studi dokumen. Hasil penelitian menunjukkan bahwa program PKH di Nagari Lagan Hilir Punggasan sudah efektif jika dilihat dari tujuan program. Namun di sisi lain penetapan sasaran penerima bantuan PKH bagi RTSM di Nagari Lagan Hilir Punggasan belum bisa dikatakan efektif penentuan sasaran belum tepat sasaran
Penanaman Nilai Dalam Pembelajaran PKn Melalui Inovasi Pendekatan Value Clarification Technique (VCT) Di Sekolah
Authors: Sudirman Sudirman 
Published: June 2021

PKN learning, in many cases emphasis on the formal need and the other side neglectful the real needs of students. This process caused lessons can not be optimal for developing the potential of children. Educational cant touch character and morality of formation. Its process resulting dehumanization and moral degradation. VCT in a planned approach with new innovations that interface the method of discussion, brainstorming, role play, case studies, out bound and muhasabah, would give better results, including the process of value investment. It is as an answer to the educational needs of the era that today's challenging.Banyak ditemukan dilapangan bahwa pembelajaran PKN lebih menekankan pada aspek kebutuhan formal dibanding kebutuhan riil siswa. Dampakanya proses pembelajaran yang dilakukan belum dapat optimal untuk mengembangkan potensi anak. Pendidikan kurang menyentuh pada pembentukan watak dan moralitas seseorang sehingga yang muncul adalah dehumanisasi dan dekadensi moral. Pendekatan VCT secara terencana dengan inovasi inovasi baru yang dintegrasikan dengan metode diskusi, curah pendapat, bermain peran, studi kasus, out bound dan muhasabah, tentu akan memberikan hasil yang lebih baik termasuk dalam proses penanaman nilai. Hal ini sebagai suatu jawaban akan kebutuhan pendidikan diera yang penuh tantangan saat ini.
Strategi Komunikasi Persuasif Dalam Menciptakan Masyarakat Sadar Wisata Di Kawasan Wisata Pantai Padang, Kota Padang
Authors: Hanana Alna , Elian Novi , Marta Revi 
Published: June 2021

Tourism is an important asset to regional income and a place of creativity promote the region characteristics. This study aims to analyze persuasive communication strategy conducted by Government, analyzing the communication barriers that occur in the process of forming a tourism conscious society, and purpose the mode of persuasive messages and effective communication media designed to build a tourism conscious society. This study uses a qualitative approach to get the facts from the symptoms that exist and seek information factually. The results show the main persuasive communication strategy undertaken by the government is forming a ‘pokdarwis’ (tourism awareness group). However, this strategy can still be used in various forms, such as: pokdarwis has not acted as an agent of change, unclear tasks distribution in pokdarwis group, un-maximized media, uncontinuity press release, and no synergy among stakeholders. A persuasive message form that can be designed to maximize this communication strategy can be a one-sided and two-sided message. The good government and groups that have been formed this hopefully can use the media consistently so that messages can reach various layers of society. Media that could be matches with the target audience were print media media, outdoor media, group communication media, personal communication channels and internet. Pariwisata merupakan asset yang sangat penting dalam menyumbang terhadap pendapatan daerah dan ajang kreativitas untuk memperkenalkan ciri khas daerah. Untuk itu, penting strategi komunikasi persuasif sebagai faktor penarik kunjungan wisatawan. Penelitian ini bertujuan menganalisis strategi komunikasi persuasif yang dilakukan oleh Pemerintah Kota Padang, hambatan komunikasi dalam proses pembentukan masyarakat sadar wisata, dan menawarkan pesan persuasif dan media komunikasi efektif yang dapat dirancang untuk membentuk masyarakat sadar wisata. Penelitian ini menggunakan pendekatan kualitatif untuk memperoleh fakta-fakta dari gejala-gejala yang ada dan mencari keterangan secara faktual. Hasil penelitian menunjukkan strategi komunikasi persuasif utama yang dilakukan oleh pemerintah berupa pembentukan pokdarwis (kelompok sadar wisata). Strategi ini masih menemui berbagai hambatan dalam pelaksanaannya, seperti: pokdarwis belum bertindak sebagai agent of change, tidak duduknya tugas di kelompok pokdarwis, media yang belum dimaksimalkan, tidak adanya kontinuitas press release, dan tidak adanya sinergi antar stakeholder. Bentuk pesan persuasif yang dapat dirancang untuk memaksimalkan strategi komunikasi ini bisa berupa one-side issue dan two-side issue message. Media yang cocok dengan target khalayaknya di antaranya media cetak, media luar ruang, media komunikasi kelompok, saluran komunikasi pribadi dan internet.