bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between pre‐pregnancy body mass index and gestational weight gain and perinatal outcomes in pregnant women diagnosed with gestational diabetes mellitus: The Japan Environment and Children's Study
Authors: Saito Yoshihiro , Kobayashi Sumitaka , Ikeda‐Araki Atsuko , Ito Sachiko , Miyashita Chihiro , Kimura Takashi , Hirata Takumi , Tamakoshi Akiko , Mayama Michinori , Noshiro Kiwamu , Nakagawa Kinuko , Umazume Takeshi , Chiba Kentaro , Kawaguchi Satoshi , Morikawa Mamoru , Cho Kazutoshi , Watari Hidemichi , Ito Yoshiya , Saijo Yasuaki , Kishi Reiko ,   the Japan Environment and Children's Study (JECS) group
Published: November 2021

AbstractAims/IntroductionWe investigated the association between gestational diabetes mellitus (GDM) and perinatal outcomes stratified by pre‐pregnancy body mass index (BMI) and/or gestational weight gain (GWG).Materials and MethodsData from the national birth cohort in the Japan Environment and Children's Study from 2011 to 2014 (n = 85,228) were used. Japan uses the GDM guidelines of the International Association of Diabetes and Pregnancy Study Groups. The odds ratios (ORs) of perinatal outcomes were compared between women with and those without GDM.ResultsThe OR (95% confidence interval) of having a small for gestational age infant in the GDM group with a pre‐pregnancy BMI of ≥25.0 kg/m2 and insufficient GWG (<2.75 kg) was 1.78 (1.02–3.12). The OR of having a large for gestational age infant of the same BMI group with excessive GWG (>7.25 kg) was 2.04 (1.56–2.67). The OR of hypertensive disorders of pregnancy was higher in women with a BMI ≥18.5 kg/m2 in the GDM group than in the non‐GDM group.ConclusionsLarge for gestational age and hypertensive disorders of pregnancy were associated with pre‐pregnancy BMI and GWG in either normal weight or overweight/obese women, and the relationship was strengthened when GDM was present. Women with GDM and a BMI of ≥25.0 kg/m2 are at risk of having small for gestational age and large for gestational age infants depending on GWG.
Safety and efficacy of mesotherapy in the treatment of melasma: A review article
Authors: Khalili Maryam , Amiri Rezvan , Iranmanesh Behzad , Zartab Hamed , Aflatoonian Mahin 
Published: November 2021

AbstractBackgroundMesotherapy is a popular novel therapeutic modality that is defined as intradermal or subcutaneous microinjection of pharmaceutical compounds. Although this novel treatment method is used commonly in aesthetic dermatology, there is little information about details of injections, efficacy, and side effects of mesotherapy in melasma.AimIn this review, we evaluated efficacy and safety of various types of mesotherapy in the treatment of melasma.MethodWe searched Google Scholar, Medline, and PubMed for related articles with keywords “melasma” OR “chloasma” AND “mesotherapy” OR “injection.” Inclusion criteria were articles that evaluated intradermal injection of lightening drugs and published dates between January 2000 and September 2021. Exclusion criteria were articles in languages other than English or non‐human studies.ResultsThirty‐three articles evaluated efficacy of mesotherapy in melasma, including 28 articles about tranexamic acid, 4 articles about vitamin C, 2 articles about glutathione, and 2 articles about triamcinolone.ConclusionMesotherapy is a good alternative or adjunctive choice in patients who are refractory to first‐line therapy, patients with low compliance with everyday use of topical therapy, patients with contraindication to oral tranexamic acid therapy, or who wish short downtime and fast recovery period. Further studies with large sample sizes are required to determine ideal concentrations of mesotherapy substances and intervals between sessions and to evaluate the efficacy of different substances for mesotherapy as monotherapy compared to combination therapy and other treatment modalities for melasma.
Relationship Between Impulsivity and Binge Eating in Japanese Adult Women: Using a Japanese Version of S‐UPPS‐P Impulsive Behavior Scale
Authors: Suzuki Tomohiro , Yamamiya Yuko , Yazawa Mikako 
Published: November 2021

AbstractThis study investigated the relationship between impulsivity and binge eating in Japanese adult women. In Study 1, we created a Japanese version of a psychological scale named the Short‐Urgency‐Premeditation‐Perseverance‐Sensation Seeking‐Positive Urgency (S‐UPPS‐P) Impulsive Behavior Scale to assess impulsivity in a Japanese sample, and confirmed good reliability and validity. Then, the relationship between impulsivity and binge eating was examined by mediating analyses, regression analyses, and structural equation modeling in Study 2. Results indicated that both negative urgency and positive urgency directly led to binge eating. Moreover, sensation‐seeking led to binge eating via unstructured dieting. Hence, our findings suggest that impulsivity has two routes to binge eating. One is the direct route to binge eating and the other is the indirect route via dieting behavior.
Protein turnover in the developing Triticum aestivum grain
Authors: Cao Hui , Duncan Owen , Millar A. Harvey 
Published: November 2021

Summary

Protein abundance in cereal grains is determined by the relative rates of protein synthesis and protein degradation during grain development but quantitation of these rates is lacking.

Through combining in vivo stable isotope labelling and in‐depth quantitative proteomics, we have measured the turnover of 1400 different types of proteins during wheat grain development.

We demonstrate that there is a spatiotemporal pattern to protein turnover rates which explain part of the variation in protein abundances that is not attributable to differences in wheat gene expression. We show that c. 20% of total grain adenosine triphosphate (ATP) production is used for grain proteome biogenesis and maintenance, and nearly half of this budget is invested exclusively in storage protein synthesis. We calculate that 25% of newly synthesized storage proteins are turned over during grain development rather than stored.

This approach to measure protein turnover rates at proteome scale reveals how different functional categories of grain proteins accumulate, calculates the costs of protein turnover during wheat grain development and identifies the most and the least stable proteins in the developing wheat grain.
The absence of differential electrodermal responding in the second half of acquisition does not indicate the absence of fear learning
Authors: Lipp Ottmar V. , Luck Camilla C. , Waters Allison M. 
Published: November 2021

AbstractMany contemporary studies of human fear conditioning exclude participants who fail to show differential electrodermal responding during late stages of acquisition training, deeming them to be non‐Learners. The current study examined whether non‐Learners, defined as those who fail to show larger electrodermal first interval responses to CS+ than to CS− in the second half of acquisition, show differential electrodermal responding early during acquisition or during extinction or evidence of fear‐learning on other measures, including rated CS valence and contingency report. In a sample of 351 participants who completed a standard differential fear‐conditioning paradigm that employed electrodermal first and second interval responses (FIR, SIR), continuous CS evaluations, and post‐experimental contingency reports to assess fear‐learning, 74 participants were identified as non‐Learners. These non‐Learners displayed overall smaller electrodermal responses but showed evidence for differential conditioning during acquisition in electrodermal FIR (block1) and SIR (blocks 2–3) and in CS evaluations during acquisition (blocks 2–4) and extinction (blocks 1–4). Fifty‐nine non‐Learners correctly reported the contingencies. A lack of differential electrodermal first interval responding during the second half of acquisition does not indicate the absence of fear‐learning. Rather, this criterion appears to capture participants who exhibit low physiological arousal and performance decrements toward the end of acquisition. Applying criteria based on “end of acquisition” electrodermal responding to determine “non‐learning” results in the exclusion of participants who display fear‐learning at other experimental stages or in other measures.
Risk classification and the balance of information in insurance; an alternative interpretation of the evidence
Authors: de Jong Casper H. 
Published: November 2021

AbstractThe purpose of this paper is to enhance understanding of the factors influencing the balance of information between policyholder and insurer. The emphasis is on the effects of risk classification. Starting from a theoretical scenario in which efficient risk classification prevents adverse selection, impediments to such risk classification and the effects of differences between insurers in this respect are being discussed. This approach offers both a more realistic and a simpler explanation for the presence of adverse selection.
Geodynamic Evolution of the Western Part of the Russian Arctic and Its Diamond Potential
Authors: Sorokhtin N. O. , Kozlov N. E. 
Published: November 2021

Abstract
The study of the geodynamic evolution of the Baltic Shield showed that the melts of diamondiferous kimberlites and related rocks were formed due to the pulling of “heavy” ferruginous sediments of the Early Proterozoic into subduction zones beneath the Archean cratons. Later, during the Neoproterozoic and Paleozoic stages of rifting, melts conserved in the lower crust and subcrustal lithosphere were able to penetrate into the near-surface zones of the crust and form magmatic complexes of alkaline–ultramafic and kimberlite magmatism. The authors showed that diamondiferous kimberlite and lamproite explosion pipes, as well as related carbonatite and alkaline–ultramafic intrusions, are mainly located above the subduction zones of the Svecofennian (Karelian) plates, which functioned about 2.0–1.8 Ga ago. At the same time, alkaline ultramafic intrusions and (sodium) carbonatites are located closest to the front of the subduction zone of Proterozoic plates (from 100 to 200–300 km). Then (at a distance of 200 to 400 km), there is a zone of location of calcite carbonatites and melilitites, and sometimes nondiamondiferous kimberlites. Diamondiferous kimberlite and lamproite diatremes are located farther than other similar formations approximately 300 to 600–650 km from its front. Such a regular spatial arrangement of magmatic complexes of a single series unambiguously indicates a change in depth of their origin. The farther from the surface boundary of the paleosubduction zone the magmatic bodies are located, the deeper the facies representing them.
Is cardiac involvement prevalent in highly trained athletes after SARS-CoV-2 infection? A cardiac magnetic resonance study using sex-matched and age-matched controls
Authors: Szabó Liliána , Juhász Vencel , Dohy Zsófia , Fogarasi Csenge , Kovács Attila , Lakatos Bálint Károly , Kiss Orsolya , Sydó Nóra , Csulak Emese , Suhai Ferenc Imre , Hirschberg Kristóf , Becker Dávid , Merkely Béla , Vágó Hajnalka 
Published: November 2021

ObjectivesTo investigate the cardiovascular consequences of SARS-CoV-2 infection in highly trained, otherwise healthy athletes using cardiac magnetic resonance (CMR) imaging and to compare our results with sex-matched and age-matched athletes and less active controls.MethodsSARS-CoV-2 infection was diagnosed by PCR on swab tests or serum immunoglobulin G antibody tests prior to a comprehensive CMR examination. The CMR protocol contained sequences to assess structural, functional and tissue-specific data.ResultsOne hundred forty-seven athletes (94 male, median 23, IQR 20–28 years) after SARS-CoV-2 infection were included. Overall, 4.7% (n=7) of the athletes had alterations in their CMR as follows: late gadolinium enhancement (LGE) showing a non-ischaemic pattern with or without T2 elevation (n=3), slightly elevated native T1 values with or without elevated T2 values without pathological LGE (n=3) and pericardial involvement (n=1). Only two (1.4%) athletes presented with definite signs of myocarditis. We found pronounced sport adaptation in both athletes after SARS-CoV-2 infection and athlete controls. There was no difference between CMR parameters, including native T1 and T2 mapping, between athletes after SARS-CoV-2 infection and the matched athletic groups. Comparing athletes with different symptom severities showed that athletes with moderate symptoms had slightly greater T1 values than athletes with asymptomatic and mildly symptomatic infections (p<0.05). However, T1 mapping values remained below the cut-off point for most patients.ConclusionAmong 147 highly trained athletes after SARS-CoV-2 infection, cardiac involvement on CMR showed a modest frequency (4.7%), with definite signs of myocarditis present in only 1.4%. Comparing athletes after SARS-CoV-2 infection and healthy sex-matched and age-matched athletes showed no difference between CMR parameters, including native T1 and T2 values.
Rhinothermy delivered by nasal high flow therapy in the treatment of the common cold: a randomised controlled trial
Authors: Bird Grace , Braithwaite Irene , Harper James , Koorevaar Iris , van den Berg Marthe , Maijers Ingrid , Kearns Nethmi , Dilcher Meik , Jennings Lance , Fingleton James , Shortt Nick , Weatherall Mark , Beasley Richard 
Published: November 2021

BackgroundThe common cold is the most common infectious disease affecting humans and has a substantial economic impact on society. Human rhinoviruses, which cause almost two-thirds of colds, have demonstrated temperature-dependent replication which is optimal between 33°C and 35°C.MethodsThis randomised, single-blind, parallel-group trial completed at a single-centre in New Zealand, recruited 170 participants aged 18–75 years (mean age 27.5 years) who were within 48 hours of common cold symptom onset and had a symptom score (the Modified Jackson Score (MJS)) ≥7 and a negative point-of-care test for influenza. Participants were blinded to the intervention and randomised (1:1) to 5 days of either nasal high flow rhinothermy (rNHF) (100% humidified air delivered at 35 L/min and 41°C for 2 hours daily) (n=85) or ‘sham’ rhinothermy (100% humidified air delivered at 10 L/min and 31°C for 10 min daily) (n=85) and completed daily symptom diaries, which included the MJS, for 14 days, to investigate whether rNHF reduced common cold symptom severity and duration compared with ‘sham’ rhinothermy.ResultsAn intention-to-treat superiority analysis included all randomised participants and showed no difference between treatment groups for the primary outcome, the day 4 MJS analysed by analysis of covariance: mean (SD) 6.33 (3.97) for rNHF vs 5.8 (3.15) for ‘sham’; estimated difference (95% CI) 0.37 (−0.69 to 1.42), p=0.49. There was no difference in time until resolution of symptoms: mean (SD) 5.96 (4.47) days for rNHF vs 6.42 (4.09) days for ‘sham’; estimated difference (95% CI) 1.02 (0.75 to 1.38), p=0.91. There were no serious adverse events related to the study treatments.ConclusionsThis well-powered, single-blind randomised controlled trial does not provide evidence that 5 days of rNHF (100% humidified air heated to 41°C delivered at 35 L/min for 2 hours daily) reduces common cold symptom severity or duration. However, investigation of rNHF in the treatment of influenza is warranted.Trial registration numberACTRN12617001340325.
Study protocol for an online randomised controlled trial among non-treatment seeking problem gamblers: training inhibition in online problem gambling (TRAIN-online) trial
Authors: Santiago Antoine , Carré Arnaud , Miranda Ruben , Lemogne Cédric , LeStrat Yann , Benyamina Amine , Perney Pascal , Luquiens Amandine 
Published: November 2021

IntroductionDevelopment of fully internet-based programs could provide a new avenue to improve access to healthcare for problem gamblers. In this project, we aim to assess the efficacy of a web-based cognitive intervention targeting inhibitory control among problem gamblers, using a randomised controlled design. As impaired inhibitory control is involved in self-regulation difficulties in behavioural addictions, it represents a particularly relevant cognitive process to target for an online psychological intervention.Methods and analysisThis will be a single-blinded, randomised, comparative therapeutic web-based, controlled trial. Up to 200 non-treatment seeking adult problem gamblers with a Problem Gambling Severity Index-recent (PGSI-recent) score ≥5 will be included. The intervention will be a computerised cognitive training program targeting inhibitory skills. The comparator, an active control, will be a computerised neutral sensorial program. Both programs will be carried out under similar conditions: biweekly online training for 6 weeks and optional telephone support will be offered to patients for debriefing. The main objective of the study is to assess the clinical efficacy of the online cognitive training program at 6 weeks, measured with the PGSI-recent. The secondary objectives are to assess the efficacy on the gambling behaviour assessed by the account-based gambling data, on the self-reported gambling practice, and on the inhibition performance at the neuropsychological level at 6, 14 and 52 weeks. We will also assess the acceptability of this program and the preferred level of guidance. Data analysis will be in intention-to-treat.Ethics and disseminationThis randomized controlled trial will be executed in compliance with the Helsinki Declaration, and was approved by the local ethics boards (Comité de Protection des Personnes) in October 2017. The findings will be published in peer-reviewed journals.Trial registration numberNCT03673800.
Psychological impact of repeated epidemic exposure on healthcare workers: findings from an online survey of a healthcare workforce exposed to both SARS (severe acute respiratory syndrome) and COVID-19
Authors: Chan Lai Gwen , Tan Pei Lin Lynnette , Sim Kang , Tan Ming Yee , Goh Kah Hong , Su Pei Qi , Tan Alvin Kah Heng , Lee Eng Sing , Tan Shu Yun , Lim Wen Phei , Aw Chia Hui , Goh Yi Zhen , Sadarangani Sapna , Chow Angela 
Published: November 2021

ObjectiveTo measure the psychological well-being of healthcare workers (HCWs) during this COVID-19 pandemic and examine the experiences of the subgroup of participants who were also HCWs during the 2003 SARS epidemic.DesignAnonymous online survey adapted from a similar study conducted during the SARS epidemic, disseminated from July 2020 to August 2020.SettingNine healthcare institutions across Singapore ranging from primary care, community care, tertiary care and specialised referral centres.ParticipantsEmployees working in the participating healthcare institutions.ResultsOf 3828 survey returns, 3616 had at least one completed item on the questionnaire. Majority were female (74.7%), nurses (51.7%), foreign-born (53.2%) and not working in the tertiary care setting (52.1%). The median score on the Impact of Events Scale (IES) was 15 (IQR 23) and 28.2% of the sample scored in the moderate/severe range. 22.7% of the participants were also HCWs during SARS and more than half of them felt safer and better equipped in the current pandemic. 25.2% of SARS HCWs and 25.9% of non-SARS HCWs had moderate/severe IES scores (p=0.904). After adjusting for age, marital status, parity and length of work experience, racial minority groups and living apart from family were independent predictors of high IES regardless of prior SARS epidemic experience. Daily exposure to confirmed or suspect COVID-19 cases increased the odds of high IES for non-SARS HCWs only.Conclusions and relevanceOverall, while 28% of HCWs in our study suffered from significant trauma-related psychological symptoms regardless of prior experience with the SARS epidemic, those with prior experience reported feeling safer and better equipped, finding the workload easier to manage, as well as having more confidence in their healthcare leaders. We recommend for more trauma-informed support strategies for our HCWs especially those from racial minority groups, who are foreign-born and isolated from their families.
FOREST protocol: a qualitative study exploring health and sexuality of transmasculine individuals in France
Authors: Mabire Xavier , Robin-Radier Suzanne ,   OUTrans NGO, Ferraz Dulce , Preau Marie 
Published: November 2021

IntroductionWhile current research on sexuality and health often explores sexual behaviours among heterosexual and gay cisgender individuals, little is known about the sexualities of transgender people, especially transmasculine people. When data are available, sexual health is often reduced to risk exposure, not considering in detail social context and determinants that could contribute to a more comprehensive approach, such as general health, class, race, exposure to violence or social representations. Recognising this gap, identified in both national (French) and international scientific literature, this study aims to explore the sexual health of transmasculine people, employing an intersectional approach and considering both positive and negative health determinants.MethodsThis 2-year research based in the disciplinary field of social psychology, with a gender perspective, and will apply qualitative methods. We adopt a community-based research approach, integrating one university and one community-based organisation in the coordination of the study. In a triangulation perspective, two rounds of semistructured interviews will be performed with key informants (medical practitioners, community-based support services workers, etc) and with people self-identifying as transmasculine. Focus groups will complement data collection.Ethics and disseminationFOREST protocol was approved by the Comité d’Évaluation Éthique (CEEI) de l’Institut National de la Santé Et de la Recherche Médicale (CEEI/International Review Board 00003888). The research adopts the principles of open science, and findings will be published assuring participants’ confidentiality. Informative flyers and videos will be elaborated to communicate study findings to participants, stakeholders and the transcommunities at large, and data will be stored in lasting archives.