bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enthesitis in Psoriatic Arthritis, the Sonographic Perspective
Authors: Smerilli Gianluca , Di Matteo Andrea , Cipolletta Edoardo , Grassi Walter , Filippucci Emilio 
Published: August 2021

AbstractPurpose of ReviewTo provide an overview of the ultrasound (US) studies focusing on enthesitis in psoriatic arthritis (PsA).Recent FindingsLast-generation US equipment has demonstrated the ability to detect subtle morphostructural and vascular abnormalities at entheseal level. US is able to identify pathologic changes in both “classical” (i.e., the site of attachment of tendons, ligaments, and joint capsules into the bone) and “functional” entheses (i.e., anatomical regions where tendons or ligaments wrap around bony pulleys).SummaryUS has the potential to be the first-line method in the assessment of enthesitis. In the present review we critically discussed the current definitions of US enthesitis, the scoring systems, and the main fields of application (i.e., the detection of enthesitis in PsA and psoriasis, the identification of different disease subsets, and the assessment of response to treatment).
Qualifizierung der Qualifizierenden
Authors: Prigge Jessica , Thole Werner , Engelbracht Mischa 
Published: August 2021

ZusammenfassungDie wachsende Aufmerksamkeit für die Lebensphase Kindheit fordert die beruflichen Qualifizierungsformate wie die entsprechenden akademischen Studienprogramme. Die Bewältigung des diagnostizierten Fachkräftebedarfs und die damit eng verbundene Herausforderung der weiteren Professionalisierung sind unterdessen nach wie vor ungelöst. Vor diesem Hintergrund werden in dem Beitrag Wandlungsprozesse sozialpädagogischer Qualifizierungsformate skizziert und an bildungsorientierte Erwartungen erinnert, die eine Ausdifferenzierung spezifisch fachlicher Inhalte und didaktischer Überlegungen anregen.
Muslimische Jugendverbände
Authors: Greschner Deniz 
Published: August 2021

ZusammenfassungDer Beitrag gibt einen Einblick in die diversen Inhalte und Organisationsformen von Jugendverbänden, die sich in ihrer Selbstbeschreibung öffentlich als „muslimisch“ positionieren. Weiter thematisiert er die Bedeutung von „safer spaces“ (Schutzräume) in diesen Jugendverbänden und beschreibt, wie muslimische Jugendliche diese Räume verstehen. Welche sozialen Kategorien, intersektionalen Erfahrungen und ihre wechselwirkende Beziehung sind hier einflussreich? Welche Rolle spielen diese Räume in den Strukturen der Jugendverbandsarbeit?
Modelling Neighbourhood Effects in Three Dutch Cities Controlling for Selection
Authors: Troost Agata A. , van Ham Maarten , Janssen Heleen J. 
Published: August 2021

AbstractThe non-random selection of people into neighbourhoods complicates the estimation of causal neighbourhood effects on individual outcomes. Measured neighbourhood effects could be the result of characteristics of the neighbourhood context, but they could also result from people selecting into neighbourhoods based on their preferences, income, and the availability of alternative housing. This paper examines how the neighbourhood effect on individual income is altered when geographic selection correction terms are added as controls, and how these results vary across three Dutch urban regions. We use a two-step approach in which we first model neighbourhood selection, and then include neighbourhood choice correction components in a model estimating neighbourhood effects on individual income. Using longitudinal register datasets for three major Dutch cities: Amsterdam, Utrecht and Rotterdam, and multilevel models, we analysed the effects for individuals who moved during a 5-year period. We show that in all cities, the effect of average neighbourhood income on individual income becomes much smaller after controlling for explicitly modelled neighbourhood selection. This suggests that studies that do not control for neighbourhood selection most likely overestimate the size of neighbourhood effects. For all models, the effects of neighbourhood income are strongest in Rotterdam, followed by Amsterdam and Utrecht.
Scientific Evidence and the Internalism–Externalism Distinction
Authors: Egeland Jonathan 
Published: August 2021

AbstractConsiderations of scientific evidence are often thought to provide externalism with the dialectical upper hand in the internalism–externalism debate. How so? A couple of reasons are forthcoming in the literature. (1) Williamson (2000) argues that the E = K thesis (in contrast to internalism) provides the best explanation for the fact that scientists appear to argue from premises about true propositions (or facts) that are common knowledge among the members of the scientific community. (2) Kelly (Philosophy Compass, 3 (5), 933–955, 2008; 2016) argues that only externalism is suited to account for the public character of scientific evidence. In this article, I respond to Williamson and Kelly’s arguments. First, I show that the E = K thesis isn’t supported by the way in which we talk about scientific evidence, and that it is unable to account for facts about what has been regarded as scientific evidence and as justified scientific belief in the history of science. Second, I argue that there are internalist views that can account for the publicity of scientific evidence, and that those views indeed do better in that regard than the (externalist) view proposed by Kelly. The upshot is that considerations of scientific evidence do not favor externalism over internalism.
Accelerating the pace of ecotoxicological assessment using artificial intelligence
Authors: Song Runsheng , Li Dingsheng , Chang Alexander , Tao Mengya , Qin Yuwei , Keller Arturo A. , Suh Sangwon 
Published: August 2021

AbstractSpecies Sensitivity Distribution (SSD) is a key metric for understanding the potential ecotoxicological impacts of chemicals. However, SSDs have been developed to estimate for only handful of chemicals due to the scarcity of experimental toxicity data. Here we present a novel approach to expand the chemical coverage of SSDs using Artificial Neural Network (ANN). We collected over 2000 experimental toxicity data in Lethal Concentration 50 (LC50) for 8 aquatic species and trained an ANN model for each of the 8 aquatic species based on molecular structure. The R2 values of resulting ANN models range from 0.54 to 0.75 (median R2 = 0.69). We applied the predicted LC50 values to fit SSD curves using bootstrapping method, generating SSDs for 8424 chemicals in the ToX21 database. The dataset is expected to serve as a screening-level reference SSD database for understanding potential ecotoxicological impacts of chemicals.
Does the socio-demographic profile of patients limit access to bariatric surgery?
Authors: Richard Viviane , Stähli Christof , Giudicelli Guillaume , Worreth Marc Daniel , Krähenbühl Nicole , Greiner Emilie , Papastathi Chrysoula , Diana Michele , Saadi Alend 
Published: August 2021

Abstract
Purpose
Surgery remains the only treatment allowing for a significant and sustainable weight loss in case of severe obesity. Patients undergo a specific multidisciplinary preparation and selection before the operation. This study aims to correlate the psychosocial profile with the likelihood of undergoing bariatric surgery in patients enrolled in the preparation program of a Swiss reference center.

Methods
All patients referred to an obesity center between January 1, 2016, and June 30, 2017, seeking a first bariatric procedure were included. Socio-demographic data, BMI, preoperative psychological and dietary evaluations were collected. Usually, the preoperative process lasts 1 year. Patients who left the preparation or who had not undergone surgery after more than 2 years of follow-up were considered withdrawers. Surgery completion predictors were reviewed with bivariate analysis and socio-demographic clusters established using the K-means method.

Results
Out of a total of 221 patients, 99 (45%) patients had not undergone bariatric surgery 2 years after their first consultation. The patients were divided into four distinct socio-demographic clusters, among which a particularly deprived one. Criteria such as unfavorable psychological (p < 0.001) and dietary (p < 0.001) evaluations, and male gender (p < 0.05) were significantly associated with non-operation, unlike socio-demographic indicators and clusters (p > 0.1).

Conclusion
Almost half of the patients starting a bariatric program are not operated on, which is related to an unfavorable psychological or dietary evaluation and to the male gender. This study also demonstrates that a significant share of patients combines several factors of social deprivation, without influencing the likelihood of surgery completion.

Level of evidence
Level V: Descriptive study.
Canopy Exchange and Modification of Nitrogen Fluxes in Forest Ecosystems
Authors: Guerrieri Rossella , Templer Pamela , Magnani Federico 
Published: August 2021

Abstract
Purpose of Review
We provide an overview of the main processes occurring during the interactions between atmospheric nitrogen and forest canopies, by bringing together what we have learned in recent decades, identifying knowledge gaps, and how they can be addressed with future research thanks to new technologies and approaches.

Recent Findings
There is mounting evidence that tree canopies retain a significant percentage of incoming atmospheric nitrogen, a process involving not only foliage, but also branches, microbes, and epiphytes (and their associated micro-environments). A number of studies have demonstrated that some of the retained nitrogen can be assimilated by foliage, but more studies are needed to better quantify its contribution to plant metabolism and how these fluxes vary across different forest types. By merging different approaches (e.g., next-generation sequence analyzes and stable isotopes, particularly oxygen isotope ratios) it is now possible to unveil the highly diverse microbial communities hidden in forest canopies and their ability to process atmospheric nitrogen through processes such as nitrification and nitrogen fixation. Future work should address the contribution of both foliar nitrogen uptake and biological transformations within forest canopies to whole ecosystem nitrogen cycling budgets.

Summary
Scientists have studied for decades the role of forest canopies in altering nitrogen derived from atmospheric inputs before they reach the forest floor, showing that tree canopies are not just passive filters for precipitation water and dissolved nutrients. We now have the technological capability to go beyond an understanding of tree canopy itself to better elucidate its role as sink or source of nutrients, as well as the epiphytes and microbial communities hidden within them.
Chatbot-Delivered Cognitive Defusion versus Cognitive Restructuring for Negative Self-Referential Thoughts: A Pilot Study
Authors: Lavelle Joseph , Dunne Neil , Mulcahy Hugh E. , McHugh Louise 
Published: August 2021

AbstractConversational agents or chatbots are a novel, highly accessible, and low-resource method of psychological intervention delivery. The present research aims to compare two brief chatbot interventions that delivered cognitive restructuring and defusion interventions, respectively. It was hypothesized that a defusion chatbot would lead to reduced cognitive fusion and decreased thought believability relative to cognitive restructuring and a nonactive control. Participants (N = 223; M age of 28.01 [SD = 10.29]; 47 identified as male, 174 as female, and 2 as nonbinary) were randomized into one of three conditions (defusion, restructuring, control), engaged for 5 days completing thought and mood measures pre- and postintervention. Sixty-two participants (M age of 25.98; SD = 8.647 years) completed measures again at time 2 (49 identified as female, 12 as male, and 1 as nonbinary). No statistically significant differences were observed among groups on believability of thoughts (F[2, 25] = .79, p = .47, ηp2 = .06), negativity of thoughts (F[2,25] = 1.49, p = .25, η 2 = .11), discomfort associated with thoughts (F[2, 25] = .48, p = .62, ηp2 = .04), and willingness (F[2, 25] = 3.00, p = .07, ηp2 = .19) to have negative self-referential thoughts. Moreover, substantial attrition of 72% was observed. Acceptability and usability of the chatbots employed are discussed as contributing toward the limited effectiveness of interventions and elevated attrition. Various recommendations are presented to support researchers and clinicians in developing engaging and effective chatbots.
Portfolio optimization model with uncertain returns based on prospect theory
Authors: Li Yufeng , Zhou Bing , Tan Yingxue 
Published: August 2021

AbstractWhen investing in new stocks, it is difficult to predict returns and risks in a general way without the support of historical data. Therefore, a portfolio optimization model with an uncertain rate of return is proposed. On this basis, prospect theory is used for reference, and then the uncertain return portfolio optimization model is established from the perspective of expected utility maximization. An improved gray wolf optimization (GWO) algorithm is designed because of the complex nonsmooth and nonconcave characteristics of the model. The results show that the GWO algorithm is superior to the traditional particle swarm optimization algorithm and genetic algorithm.
International Protection of Foreign Investments in Offshore Energy Production and Marine Environmental Protection: Birds of a Feather or Frenemies Forever?
Authors: Giannopoulos Nikolaos 
Published: August 2021

AbstractInitially, international investment law and international law on the protection of the marine environment were two branches that developed separately. As these international regimes mature, they often speak to the same facts, bringing about their ever-increasing normative interaction, way before any disputes arise. The regulation of investments in offshore energy production is chosen as a case study because it exemplifies how these two bodies of international law can interact. The article does not conceptualize these two international regimes as inherently antagonistic but instead highlights their potential complementarity. Yet, it is primarily the issue of normative conflicts between those two regimes which has generated heated scholarly debates. Against the backdrop of sweeping critiques about the potential ‘regulatory chill’ of international investment agreements and their investor-State dispute settlement mechanism, this contribution examines whether arbitral tribunals have interpreted and applied investment rules in a fashion that can unduly restrict the discretion of host States to honour their marine environmental obligations. First, it explores why and how international investment law and marine environmental law interact and influence each other’s implementation. In a second step, the article investigates the impact (if any) of investment obligations on the discretion of host States to comply with their marine environmental protection obligations. Adopting a forward-looking perspective, it finally enquires into the potential impact of the reformed provisions under new generation IIAs on the right and duty of States to take all necessary measures to protect the marine environment against pollution from offshore energy production activities.
Oridonin enhances antitumor effects of doxorubicin in human osteosarcoma cells
Authors: Kazantseva Liliya , Becerra José , Santos-Ruiz Leonor 
Published: August 2021

Abstract
Background
Doxorubicin is the chemotherapeutic drug of choice in osteosarcoma treatment, but its cumulative administration causes dilated cardiomyopathy. Combination therapy represents a potential strategy to reduce the therapeutic dosage of the chemotherapeutic agent and minimize its side effects. The aim of this study was to evaluate the potential of oridonin, a natural product from the medicinal herb Rabdosia rubescens, to act in combination with doxorubicin for osteosarcoma treatment. To date, there are no reports of the simultaneous administration of both drugs in osteosarcoma therapy.

Methods
The combined administration of different doses of oridonin and doxorubicin, as compared with the drugs alone, were tested in an in vitro model of osteosarcoma. The synergistic effect of the drugs on cell death was assessed by alamarBlue™ and by CompuSyn software. Early and late apoptosis markers (JC-1 fluorescence and Annexin V immunofluorescence), as well as the production of reactive oxygen species, were evaluated by flow cytometry. Western blot was used to assess the expression of anti-apoptotic proteins.

Results
Oridonin and doxorubicin presented a synergistic cytotoxic effect in osteosarcoma cells. In the presence of sub-cytotoxic concentrations of the natural product, there was an increased accumulation of intracellular doxorubicin, increased levels of reactive oxygen species (ROS), alteration of mitochondria membrane potential and a higher rate of apoptosis.

Conclusion
The combined use of oridonin and doxorubicin could help to reduce the clinical dosage of doxorubicin and its dangerous side effects.
The battle of YouTube, TV and Netflix: an empirical analysis of competition in audiovisual media markets
Authors: Budzinski Oliver , Gaenssle Sophia , Lindstädt-Dreusicke Nadine 
Published: August 2021

AbstractThe world of audiovisual online markets is rapidly changing. Not long ago, it was dominated by linear television, transmitted terrestrially, through cable networks or via satellite. Recently, streaming services such as Netflix, YouTube, Amazon Prime and others have emerged as new suppliers of audiovisual content. In this quickly changing industry, competition interrelations between such different formats such as traditional TV, videos on YouTube, and streaming via Netflix are subject to controversy. In particular, doubt is cast on services such as YouTube exerting competitive pressure on services such as Netflix and traditional TV. Based upon a survey with 2920 participants, we provide an empirical analysis of consumption behavior of audiovisual contents. Using descriptive and analytical statistics, including multiple equation models, we show that there are specific areas within audiovisual content markets, where YouTube exerts considerable competitive pressure on both Netflix and classic TV, for instance, through prime time video entertainment. However, our analysis yields differentiated results as we also identify areas, where competition intensity between different service types appear to be low, for instance, through daytime and regarding the intention to shorten waiting time.
Training programme in gasless laparoscopy for rural surgeons of India (TARGET study) - Observational feasibility study
Authors: Aruparayil N. , Gnanaraj J. , Maiti S. , Chauhan M. , Quyn A. , Mishra A. , Bains L. , Mathew G. , Harris C. , Cundill B. , Fellows A. , Gordon K. , Dawkins B. , Shinkins B. , Brown J. , Jayne D. 
Published: August 2021

ABSTRACT

Background:
Benefits of laparoscopic surgery are well recognised but uptake in rural settings of low- and middle-income countries is limited due to implementation barriers. Gasless laparoscopy has been proposed as an alternative but requires a trained rural surgical workforce to upscale. This study evaluates a feasibility of implementing a structured laparoscopic training programme for rural surgeons of North-East India.

Methods:
A 3-day training programme was held at Kolkata Medical College in March 2019. Laparoscopic knowledge and Fundamentals of Laparoscopic Skills (FLS) were assessed pre and post simulation training using multiple choice questions and the McGill Inanimate System for Training and Evaluation of Laparoscopic Skills (MISTELS), respectively. Competency with an abdominal lift device was assessed using the Objective Structured Assessment of Technical Skills (OSATS) and live operating performance via the Global Operative Assessment of Laparoscopic Skills (GOALS) scores during live surgery. Costs of the training programme and qualitative feedback were evaluated.

Results:
Seven rural surgeons participated. There was an improvement in knowledge acquisition (mean difference in MCQ score 5.57 (SD = 4.47)). The overall normalised mean MISTELS score for the FLS tasks improved from 386.02 (SD 110.52) pre-to 524.40 (SD 94.98) post-training (p = 0.09). Mean OSATS score was 22.4 out of 35 (SD 3.31) indicating competency with the abdominal lift device whilst a mean GOALS score of 16.42 out of 25 (SD 2.07) indicates proficiency in performing diagnostic laparoscopy using the gasless technique during live operating. Costs of the course were estimated at 354 USD for trainees and 461 USD for trainers.

Conclusion:
Structured training programme in gasless laparoscopy improves overall knowledge and skills acquisition in laparoscopic surgery for rural surgeons of North-East India. It is feasible to deliver a training programme in gasless laparoscopy for rural surgeons. Larger studies are needed to assess the benefits for wider adoption in a similar context.

Highlights
Timing of Perioperative Pharmacologic Thromboprophylaxis Initiation and its Effect on Venous Thromboembolism and Bleeding Outcomes: A Systematic Review and Meta-Analysis
Authors: McAlpine Kristen , Breau Rodney H. , Werlang Paulo , Carrier Marc , Le Gal Gregoire , Fergusson Dean A. , Shorr Risa , Cagiannos Ilias , Morash Christopher , Lavallée Luke T. 
Published: August 2021

BACKGROUND:
Perioperative thromboprophylaxis guidelines offer conflicting recommendations on when to start thromboprophylaxis. As a result, there is considerable variation in clinical practice, which can lead to worse patient outcomes. The objective of this study was to evaluate the association between the start time of perioperative thromboprophylaxis with venous thromboembolism (VTE) and bleeding outcomes.

STUDY DESIGN:
Embase, Medline, and CENTRAL (Cochrane Central Register of Controlled Trials) databases were searched on October 23, 2020. Randomized controlled trials that evaluated VTE and/or bleeding among groups receiving the initial dose of pharmacologic thromboprophylaxis at different times preoperatively, intraoperatively, or postoperatively were included. Only trials that randomized patients to the same medication among groups were eligible. Studies on any type of operation were included. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. The Cochrane Collaboration risk of bias tool was used. The review was registered with PROSPERO (International Prospective Register of Systematic Reviews; CRD42019142079). The outcomes of interest were VTE and bleeding. Prespecified subgroup analyses of studies including orthopaedic and nonorthopaedic operations were performed.

RESULTS:
A total of 22 trials (n = 17,124 patients) met eligibility criteria. Pooled results showed a nonstatistically significant decrease in the rate of VTE with preoperative initiation of thromboprophylaxis compared with postoperative initiation (risk ratio 0.77; 95% CI, 0.55 to 1.08; I
2 = 0%, n = 1,933). There was also a nonstatistically significant increase in the rate of bleeding with preoperative compared with postoperative initiation (risk ratio 1.17; 95% CI, 0.94 to 1.46; I
2 = 35%, n = 2,752). Risk of bias was moderate. Heterogeneity between studies was low (I
2 = 0% to 35%).

CONCLUSIONS:
This meta-analysis found a nonstatistically significant decrease in the rate of VTE and an increase in the rate of bleeding when thromboprophylaxis was initiated preoperatively compared with postoperatively.