bluuebunny/crossref_metadata_2025_split huggingface dataset:
A treatment strategy for meeting life as it is. Patients’ and therapists’ experiences of brief therapy in a district psychiatric centre: A qualitative study
Authors: Markussen Hilde V. , Aasdahl Lene , Viksveen Petter , Hedberg Berith , Rise Marit B. 
Published: October 2021

Background
Young adults increasingly seek help for mental health problems. In 2016, a district psychiatric centre in Norway started a brief treatment program to provide early and effective help for moderate depression and anxiety.

Aim
Exploring patients’ and therapists’ experiences of brief therapy, especially how the time limitation influences the treatment process.

Methods
Individual interviews with 12 patients and focus group interviews with eight therapists analyzed using systematic text condensation.

Results
The results constitute five themes: (1) Time-limit as a frame for targeted change, (2) Clarifying expectations and accountability, (3) Shared agreement on a defined treatment-project, (4) Providing tools instead of searching for causes, and (5) Learning to cope—not being cured.

Conclusion
Time-limitation in brief therapy appeared to play a positive role, helping the therapists to structure the therapeutic process and strengthening patients’ motivation. Shared understanding and activation during brief therapy may reinforce patients’ responsibility and expectations to achieve individual goals. Brief therapy can be viewed as the start of a personal process towards “mastering life as it is”. More research is needed to investigate the patients’ long-term outcomes after treatment and to shed light on the potential for, and limitations of, mastering everyday-life.
Rectal Indomethacin Does Not Mitigate the Systemic Inflammatory Response Syndrome in Acute Pancreatitis: A Randomized Trial
Authors: Machicado Jorge D. , Mounzer Rawad , Paragomi Pedram , Pothoulakis Ioannis , Hart Phil A. , Conwell Darwin L. , de-Madaria Enrique , Greer Phil , Yadav Dhiraj , Whitcomb David C. , Lee Peter J. , Hinton Alice , Papachristou Georgios I. 
Published: October 2021

INTRODUCTION:
Experimental data suggest that nonsteroidal antiinflammatory drugs may prevent disease severity and mortality in acute pancreatitis (AP). The aim of this study was to compare the efficacy of rectal indomethacin vs placebo in reducing the systemic inflammatory response syndrome (SIRS) score in a high-risk AP population for clinical progression.

METHODS:
We conducted a single-center, quadruple-blinded, randomized, placebo-controlled trial. Eligible criteria were subjects with AP and SIRS within 72 hours of presentation and those without organ failure. Subjects were allocated in a 1:1 ratio to indomethacin or placebo using simple randomization. Both interventions were administered rectally every 8 hours for 6 doses and compared using both intention-to-treat and per-protocol analyses.

RESULTS:
A total of 42 subjects (mean age 52 years, 55% men) were randomized to indomethacin (n = 18) or placebo (n = 24). There was no significant difference between the indomethacin and placebo groups in the change of SIRS score, proportion of subjects with SIRS, and distribution of SIRS scores at 24, 48, and 72 hours from randomization. There were no significant differences in the change of C-reactive protein levels at 48 hours or clinical outcomes between both treatment groups. Indomethacin was as safe as placebo, with 2 adverse events occurring in the placebo and none in the indomethacin arm.

DISCUSSION:
Rectal indomethacin can be safely administered over 48 hours; however, it is not superior to placebo in reducing the SIRS or clinical progression in a high-risk population with AP (ClinicalTrials.gov: NCT02692391).
THE ASSOCIATION OF TYPE D PERSONALITY AND PREMENSTRUEL SYNDROME
Authors: YILDIRIM BAŞ Funda , TOLA Esra Nur , CANKAYA Basak Asli 
Published: October 2021

Objective
Type D personality, defined as the presence of two
personality characters -negative affectivity (NA)
and social inhibition (SI), is associated with various
disorders. The aim of our study was to investigate
the association between Type D personality and
premenstruel syndrome (PMS).
Material and Methods
A total of 286 female (86 with PMS and 200 control)
were recruited for the study. The mean age of the
participants was 21.28 ± 0.12 years. Data were
obtained from the Premenstrual Syndrome Scale,
Beck Depression Inventory (BDI-21) and Type D
Personality Scale (DS14). SPSS 22 (Statistical
Package for Social Sciences) program was used to
evaluate the data. Statistical significance level was
accepted as p
Surgical treatment of patients with combined oncological and vascular pathology of the brain
Authors: Kordonskaya O. O. , Mel’chenko S. A. , Fumin I. A. , Gorojanin V. A. , Lukyanchikov V. A. , Sen’ko I. V. 
Published: October 2021

The aim of the study were describing the results of surgical treatment of patients with combined oncological and vas‑ cular pathology of the brain and analyzing the scientific literature on the treatment of such combined diseases.Materials and methods. Four patients who underwent surgery for combined oncological and vascular brain pathology in 2020 year in Federal Center for Brain and Neurotechnology and in Sklifosovsky Research Institute of Emergency Care. A review of the literature on the features of the treatment of this category of patients was carried out.Results. Surgery of such combinations is not routine for neurosurgeons; each case deserves special attention. We operated on two patients simultaneously, оne – aneurysm clipping and radiosurgical treatment of the tumor were performed.
Effect of FOXP3 gene variants on the immune-active HBV and inactive HBV phases
Authors: AKGÖLLÜ Ersin 
Published: October 2021

Purpose: FOXP3 gene rs2232365 A/G and the rs3761548 A/C polymorphisms were associated with immune system-related diseases such as Hepatitis B virus (HBV) infection. The function of Treg cells which act as immune-suppressors in the control of HBV-related liver inflammation may be affected by these polymorphisms. The aim of the present study was to evaluate the association between these polymorphisms with HBV infection phases.
Materials and Methods: The current study examined the FOXP3 gene polymorphisms in 116 patients with immune-active hepatitis B phase and in 116 individuals with inactive hepatitis B phase by a real-time polymerase chain reaction (RT-PCR).
Results: In females, the A allele and AA genotype of rs2232365 polymorphism was not statistically significant although it increased 1.28- and 1.67-fold immune-active HBV risk. Although the G allele of rs2232365 polymorphism increased 1.69-fold immune active HBV risk, it was not statistically significant in males, either. Likewise, the rs3761548 polymorphism could not reach a statistically significant value in males and females, either.
Conclusion: This research is to demonstrate the relation between phases of HBV infection and polymorphisms of the FOXP3 gene in the Turkish population. The results of this study showed that there is no effect of these polymorphisms on the immune-active phase of HBV, even though it increased immune-active HBV.
Bienvenidos al pasado
Authors: Bernazza Claudia 
Published: October 2021

Los aspectos centrales del Plan de Modernización del Estado del actual gobierno nacional son discutidos desde una perspectiva que destaca su carácter instrumental, su parentesco con similares iniciativas emprendidas en la década de 1990 en Argentina y otros países latinoamericanos en el marco del ajuste neoliberal, y su directa vinculación con organismos multilaterales de financiamiento que auspiciaron dicho ajuste. Se destaca la metamorfosis de un conjunto de cuestiones típicamente políticas (los fines perseguidos por el Estado más allá de ciertas enunciaciones convencionales, las características del proceso de desarrollo impulsado desde el Estado, la participación de los trabajadores del sector público nacional y provincial) que se presentan como asuntos estrictamente técnicos y ajenos en consecuencia a la discusión o la negociación en función de diferentes perspectivas institucionales.
Identification of Point Mutation in Exon 3 of Leptin Gene in Munjal Sheep
Authors: Kumar Sandeep , Dahiya S.P. , Magotra Ankit , Bangar Yogesh C. , Garg Asha Rani 
Published: October 2021

Background: Leptin is a varied hormone which plays vital role in body development by regulating the balance between food intake and energy expenditure by signaling to the brain. Leptin has diverse effect on controlling appetite, energy metabolism, growth, reproduction, body composition and immunity. The present study was aimed to screen candidate point mutation (g.332G greater than A) in the targeted genomic region of leptin gene in Munjal sheep. Methods: A total of 50 Munjal sheep were selected and genomic DNA was isolated in Automated Maxell RSC DNA/ RNA purification system by using Maxwell RSC whole blood DNA kit. Reported set of primers was used to amplify 463bp fragment encompassing targeted region (exon 3) of leptin gene. PCR-RFLP was performed to genotype targeted point mutation in our resource population. PCR products were digested by Cail 1 restriction enzyme to genotype g.332G greater than A (at 332th nucleotide of exon 3 leptin gene) non-synonymous mutation (Arg to Gln). Result: All studied samples resolved into monomorphic banding pattern, revealed only AA (463bp single band bp) genotype. The absence of candidate mutation in our resource population might be due to small sample size.
Efficacy of Silymarin and SAM in the Management of Hepatic Disorders in Dogs
Authors: Lakshmi K. , Padmaja K. 
Published: October 2021

Background: Treatment of canine liver diseases is often supportive and enables combinations of drug therapy and dietary support. Many nutraceutical compounds that have anti-oxidant properties have been suggested as supplements in animals suffering with hepatic diseases especially silymarin and S-adenosyl methionine The current study was aimed to evaluate therapeutic efficacy of certain nutraceuticals in the management of hepatic disorders in dogs. Methods: Dogs presented to Veterinary Hospital, Bhoiguda, Hyderabad with the clinical signs suggestive of hepatobiliary disorders were selected. Detailed history of the affected dogs was collected. Later, these cases were subjected for detailed clinical examination. While, apparently healthy dogs presented for general health checkup and vaccination with no clinical condition in the age group of 2-5 years were selected randomly as healthy control group for this study. Result: The present investigation was under taken to study the therapeutic efficacy of certain nutraceuticals in the management of hepatic disorders in dogs. Based on history, clinical signs, haemato biochemistry and ultrasonography, 32 dogs were histologically confirmed as hepatic disorders which formed the largest group. These dogs were selected for therapeutic trial. Apart from the specific drugs, addition of nutraceuticals like Silymarin and S-adenosyl methionine therapy was effective in the treatment of hepatic disorders.
​Molecular Mechanism of Extreme Hypoxia Tolerance Difference between Male and Female Adult Fish and Juvenile Fish of Acrossocheilus fasciatus by Transcriptomics
Authors: He Jinghong , Wang Handong , Guo Yongyao , Chu Zhangjie , Zhao Bo 
Published: October 2021

Background: Dissolved oxygen in water is an important limiting factor for fish. In this study, the suffocation point and transcriptomes analysis of Acrossocheilus fasciatus with different age and gender are helpful to analyze the effects of gender and age on extreme hypoxia tolerance. Methods: First of all, we compared the difference in tolerance to extreme hypoxia among 15 fish from male adult fish, female adult fish and juvenile fish of Acrossocheilus fasciatus in each group by asphyxiation point experiment. Then, we analyzed the molecular mechanism of extreme hypoxia tolerance difference between male and female adult fish and juvenile fish by transcriptomics. Result: Female adult fish of Acrossocheilus fasciatus showed the strongest tolerance to extreme hypoxia in the asphyxiation point experiment. In transcriptomes experiments in all samples, we found that the expression of ncoa4 and facl4 was significantly down regulated and the expression of jnk, gpx4 and jip-1 was significantly increased in females adult fish.
Genetic Analysis of Various Traits in Oilseed Brassicas
Authors: Ahmad Hafiz Basheer , Rauf Salsabeel , Chattha Waqas Shafqat , Khaliq Abdul , Amin Amir , Sher Rashad ul , Ali Sajid 
Published: October 2021

Background: The combining ability and manifestation of heterosis within and among the species of oilseed brassicas (B. campestris, B. napus and B. juncea) were studied for yield and yield related traits in 12F1 combinations. Methods: All crosses (12F1) along with their parents (7 parents) were sown in randomized complete block design (RCBD) with three replications. Result: The analysis of variance showed extensive variability among the genotypes. The physical appearance of interspecific crosses was intermediate. B. campestris showed significant GCA effects among lines and B. juncea among testers for seed yield per plant. General combining behaviour of B. campestris was better as compared to B. napus and B. juncea. The SCA effects were higher within species than among the species. This also revealed that within the species B. juncea had more SCA (17.45) than B. napus (9.82) and B. campestris (8.01) for seed yield. The SCA showed the improvement of B. Juncea, is the best than other two species. It is also concluded that to obtain better yield, crossing within the species is more appropriate than among the species. Moreover, to introduce novel traits in brassica species is possible through interspecific hybridization.
Corporate Social Responsibility and MNCs: An Appraisal from Investment Treaty Law Perspective
Authors: Dawood Shamila 
Published: October 2021

Recent investment treaties recognize corporate social responsibility (CSR) as a mechanism for regulating corporate behavior concerning the protection and promotion of human rights, social and environmental standards. These treaties often include a universally recognized soft law version of CSR developed by the International Labor Organization (ILO) and the Organization for Economic Co-operation and Development (OECD), considered prominent sources of CSR voluntary standards. This study analyzed significant advances in including such voluntary standards in investment treaty law, which led to implementing globally agreed norms regarding sustainable development into action. In addition to the inclusion of CSR standards in legally binding documents, this study argued that the practical issues involved in implementing the CSR standards should be addressed from the perspective of capital-dependent developing countries. To this end, this study adopted the due diligence test to apply CSR standards in cross-border investments better. For this purpose, theoretical analysis that combined descriptive and analytical approaches based on the available primary and secondary sources best suited current research. The study showed that applying CSR standards in capital-dependent developing countries was only possible when corporate, home state, and the host government took appropriate actions at the policy level. It concluded that such additional measures were needed to effectively implement CSR standards emphasizing prevention was better than cure and ensuring the appropriate due diligence process by the relevant parties.
KEYWORDS: Corporate Social Responsibility, Investment Laws, Developing Countries.
Meninjau Ulang Ketentuan Presidential Threshold dalam Pemilihan Presiden dan Wakil Presiden di Indonesia
Authors: Sumodiningrat Aprilian 
Published: October 2021

The presidential threshold is a requirement for the nomination of the President and Vice President to meet the minimum threshold percentage for support from the DPR or the number of valid national votes. Presidential threshold provisions are contained in various laws and regulations regarding Elections. This research is juridical study using a conceptual approach and statute approach. The legal materials used in this research are primary and secondary legal materials. The two legal materials are inventoried; then used as a basis for compiling a prescriptive study of the legal issues raised. The results of this study state that the presidential threshold has started since 2004. Regulations regarding post-reform elections always include a presidential threshold. Then, the presidential threshold has been 'tested' several times by the Constitutional Court. Various decisions of the Constitutional Court stated that the presidential threshold is one of the provisions which is the domain of open legal policy for legislators or the making of laws. Furthermore, the implication of the presidential threshold is aimed at simplifying the fragmentation of political parties in parliament. The nominations for the President and Vice President promoted by the parliamentary political party actually allow for more than two candidates; and it is also possible to have an Election that does not get the support of more than 50 persen of the voters' vote. Thus, effectiveness is needed regarding the implementation of the presidential threshold provisions in the presidential system by strengthening relations between presidential institutional actors and the President's non-institutional personnel.
KEYWORDS: Presidential Threshold, General Election, Open Legal Policy.
Outsourcing sebagai Pelanggaran Terhadap Hak Para Pekerja di Indonesia
Authors: Husin Zaimah 
Published: October 2021

The problem experienced by contract workers or outsourcing are quite varied, which includes the potential of human rights violations. This is because the insufficient existing regulations in Indonesia protect contract workers. This study is legal research, which uses statutory and conceptual approaches that utilize primary, secondary, and tertiary legal materials. The technique of collecting legal materials in this legal research uses literature study. This study shows that outsourcing workers are the most disadvantaged party in a work agreement, remarkably where they are terminated. The outsourcing worker will not get the normative rights like ordinary workers. Outsourced workers do not have a fixed work period. Then, the working period returns to the beginning when a work contract agreement occurs. The work contract system with probation conducted by the company directly benefits the company. It can violate human rights due to the absence of wages based on the length of work provided by the company. As a result, it is essential to pay attention to agency workers' conditions to obtain legal protection for human rights. Human rights are fundamental and must be legally protected. Thus, legal protection regarding the rights of outsourced workers can be carried out by the local government by issuing policies that regulate legal protection for agency workers. Finally, companies will pay more attention to the welfare of workers.
KEYWORDS: Outsourcing Workers, Right to Work, Legal Protection.
Língua(gem) e gênero neutro
Authors: Moura Jonathan Ribeiro Farias de 
Published: October 2021

O presente trabalho aborda o uso e a tentativa de implementação do gênero neutro na língua(gem) do português brasileiro e uma parte do histórico de tentativas que já se buscou para implementar uma língua(gem) que fosse mais inclusiva, do ponto de vista do gênero, com o -@; -X e o -E. Analisaremos esses gestos discursivos e como eles operam na língua. Como aporte teórico, nos filiamos à escola Materialista de Discurso, cujo expoente maior é Michel Pêcheux, na França, e Eni Orlandi, no Brasil. Ao fim, podemos concluir que os gestos de tentativa dos sujeitos de quererem uma língua portuguesa brasileira menos gentrificada, ou menos binária, têm um efeito político de significar sujeitos que se sentem excluídos da linguagem, no entanto, como a língua é um sistema fechado, precisa de ser atravessada por uma historicidade para fazer sentido e entrar no curso da língua(gem).
Pertanggungjawaban Administratif Juru Parkir di Tepi Jalan Umum Dalam Pemungutan Retribusi
Authors: Fuadi Hasfar , Ismail Ilyas , Saleh Muhammad 
Published: October 2021

AbstractThis paper uses a juridical empirical research method. Juridical research is using a statutory approach, namely Qanun/Perda (das sollen), while empirical research uses a field approach (das sein) by conducting direct interviews with parking attendants and parking retribution users. This study aims to understand and determine the responsibility of parking attendants on the edge of public roads in collecting retribution and applying sanctions to irresponsible parking attendants on the edge of public roads. The results of the study show that the parking attendant is required to use the official clothes/vest provided by the Banda Aceh City Transportation Service, the parking attendant at the time of collecting the parking fee is required to submit a coupon to the user of the retribution service as proof of the parking levy collection and the parking attendant is obliged to submit the levy result to the Banda City Government Aceh through the Quotation Officer assigned in accordance with the provisions that have been set, but if the parking attendant does not carry out his obligations, he will be given a sanction in the form of cancellation of the Management Agreement for the Collection of Parking Retribution. By submitting the coupon as proof of payment of the parking fee, the user of the levy service will count the number of vehicles entering and leaving. Keywords: Accountability; Retribution; Parking.AbstrakTulisan ini menggunakan metode penelitian yang bersifat yuridis empiris. Penelitian yuridis adalah menggunakan pendekatan peraturan perundang-undangan yaitu Qanun/Perda (das sollen), sedangkan penelitian empiris menggunakan pendekatan lapangan (das sein) dengan melakukan wawancara langsung terhadap Juru Parkir dan pengguna retribusi parkir. Penelitian ini bertujuan untuk memahami dan mengetahui pertanggungjawaban Juru Parkir di tepi jalan umum dalam pemungutan retribusi dan penerapan sanksi terhadap Juru Parkir di tepi jalan umum yang tidak bertanggung jawab. Hasil penelitian bahwa Juru Parkir wajib menggunakan pakaian/rompi resmi yang diberikan oleh Dinas Perhubungan Kota Banda Aceh, Juru Parkir pada saat memungut retribusi parkir wajib menyerahkan kupon kepada pengguna jasa retribusi sebagai bukti pungutan retribusi parkir dan Juru Parkir wajib menyerahkan hasil retribusi kepada Pemerintah Kota Banda Aceh melalui Juru Kutip yang ditugaskan sesuai dengan ketentuan yang telah ditetapkan, namum apabila Juru Parkir tidak melaksanakan kewajibannya maka akan diberikan sanksi berupa pembatalan Surat Perjanjian Tata Kelola Pemungutan Retribusi Parkir. Dengan diserahkannya kupon sebagai tanda bukti pembayaran retribusi parkir maka pengguna jasa retribusi akan terhitung jumlah kendaraan yang masuk dan keluar.Kata Kunci: Pertanggungjawaban; Retribusi; Parkir.