bluuebunny/crossref_metadata_2025_split huggingface dataset:
РЕАЛІЗАЦІЯ ПРАВА НА СОЦІАЛЬНИЙ ЗАХИСТ ВНУТРІШНЬО ПЕРЕМІЩЕНИМИ ОСОБАМИ: В АСПЕКТІ ЗАБЕЗПЕЧЕННЯ ПРИНЦИПУ ВЕРХОВЕНСТВА ПРАВА
Authors: Петросян К. Є. , Котова Л. В. 
Published: May 2021

У статті здійснено аналіз міжнародних та національних нормативно-правових актів, а також даних, зокрема статистичних, щодо окремих аспектів реалізації права на соціальний захист, у тому числі щодо правового забезпечення захисту внутрішньо переміщених осіб (далі – ВПО). Відзначено, що з початком збройної агресії Російської Федерації у 2014 році в Україні з’явилися особи, які з метою уникнення негативних наслідків збройного конфлікту були вимушені залишити місця свого постійного проживання та переселитися в інші регіони держави. Офіційна статистика щодо кількості взятих на облік ВПО з тимчасово окупованих територій Донецької та Луганської областей та АР Крим, та частки серед них осіб пенсійного віку в черговий раз підкреслює необхідність дослідження питання забезпечення прав внутрішньо переміщених осіб на соціальний захист та розробки ефективних механізмів вдосконалення законодавчої бази, що закріплює права і свободи внутрішньо переміщених осіб в аспекті забезпечення принципу верховенства права. Констатовано, що в аспекті забезпечення принципу верховенства права, право на соціальний захист має природно-правовий характер, тобто належить особі з моменту народження, а тому має визнаватись і гарантуватись державою. Підкреслюється неподільність принципу верховенства права з такими поняттями як демократія та права людини, в тому числі права у сфері соціального захисту. Авторами з’ясовані важливі моменти визначення понять «соціальний захист» й «соціальне забезпечення» та виокремлені три головні складові системи соціального захисту. Авторами зазначено, що існує ряд особливостей в реалізації права на соціальний захист в умовах збройного конфлікту в Україні внутрішньо переміщеними особами, зокрема: по-перше, констатовано, що право на соціальний захист внутрішньо переміщеної особи поставлено у залежність від наявності у такої особи довідки на підтвердження цього статусу; по-друге, підкреслюється, що з метою реалізації свого конституційного права особа повинна відкрити рахунок виключно в Ощадбанку; по-трете, встановлюється, що діюче законодавство передбачає обов’язок внутрішньо переміщеної особи періодично проходити фізичну ідентифікацію в установі банку; по-четверте, у разі недотримання встановлених умов особа зазнає обмеження у реалізації свого права на соціальний захист шляхом зупинення соціальних виплат, що порушує забезпечення принципу верховенства права.
Ключові слова: соціальний захист, соціальне забезпечення, система соціального захисту, реалізації права на соціальний захист, принцип верховенства права.
A study on comparison of memory boosting and regaining effects of oral administration of peppermint and coriander in wistar albino rats.
Authors: Kumar Sai Sailesh , Mohamed Jasira V k , Mukkadan JK 
Published: May 2021

The present study provides further evidence that oral administration of peppermint and coriander extracts are having memory boosting and memory regaining effects. The present study was undertaken to compare memory boosting and regaining effects of oral administration of peppermint and coriander extracts in adult wistar rats. Here we investigate the influence of oral intake of peppermint and coriander extracts on behavioral task performance by using T-maze and radial arm maze and physiological measures relative to a milk control group. When coriandrum and peppermint groups are compared, the memory boosting and regaining effects of peppermint is significant in R-maze, whereas memory boosting and regaining effects of coriandrum is significant in T-maze. We conclude that oral administration of peppermint and coriander extracts are having memory boosting and memory regaining effects. Hence we recommend peppermint and coriander can be used as a remedy in the management of Alzheimer's disease and we also recommend further research in this area by investigating compound metabolism to optimize quantification of memory performance following peppermint and coriander ingestion.
CBMJ 2014 January: Vol. 03 No. 01 P: 13-19
Prevalence of Microalbuminuria with Relation to Glycemic Control in Type-2 Diabetic Patients in Mymensingh
Authors: Hasan Mahmud Javed , Islam Nazrul , Sharmeen Atia , Kabir ATM Sulaiman , Bari Muhammad Abdul , Ahmed Sultan , Haque Amdadul 
Published: May 2021

Diabetes is one of the most common endocrine disorders characterized by hyperglycaemia. Diabetic nephropathy is a consequence of long standing diabetes. The prevalence of microalbuminuria predicts progression to diabetic nephropathy. The present study was conducted to determine the prevalence of microalbuminuria in relation to duration of diabetes, BMI, Serum Creatinine and HbA1c in an ethnic group of Type 2 diabetes mellitus residing in Mymensingh, Bangladesh. This descriptive cross-sectional study was carried out in a community based medical college hospital, located at Winnerpar, Mymensingh from July to December 2012. Fasting various blood and morning urine sample was collected for analysis of creatinine, HbA1c and microalbuminuria respectively. One hundred twenty known Type 2 diabetic patients with age 30 years and above were included in the study. Pearson correlation was applied to observe association of microalbuminuria with different parameters. Microalbuminuria had a highly significant correlation with duration of diabetes (p<0.001), serum creatinine, HbA1c (p<0.001) and BMI (p 0.001). The correlation demonstrates that with the increase in age, raised serum creatinine significantly bearing a perfect positive correlation as evident by r = 0.878, p < 0.001. The present study found an early onset of microalbuminuria in the selected community which could be due to poor glycaemic control (high HbA1c >7%) or heredity factors. Screening for microalbuminuria and HbA1c test should be done in both newly and already diagnosed Type 2 diabetic patients as an early marker of renal dysfunction and glycaemic control.
CBMJ 2014 January: Vol. 03 No. 01 P: 29-34
Bardet Biedl Syndrome
Authors: Bari Abdul , Islam Aminul , Hasan Mahmud Javed , Shamsi Shanjida , Ahmed Sultan 
Published: May 2021

Bardet Biedl syndrome is a rare autosomal recessive condition with a wide spectrum of clinical features. The accepted major criteria for diagnosis include obesity, polydactyly, male hypogonadism, mental retardation, retinal dystrophy, adrenal dysfunction. We have presented a 14 year old male patient exhibiting characteristic features of Bardet Biedl syndrome (BBS), admitted into Community Based Medical College Hospital.
CBMJ 2014 January: Vol. 03 No. 01 P: 56-59
Efektivitas Ekstrak Bawang Merah (Allium ascalonicum L) Terhadap Penurunan Suhu Tubuh Anak dengan Demam Pasca Imunisasi DPT Pentabio
Authors: Setiawandari Setiawandari , Widyawaty Eka Deviany 
Published: May 2021

The immunizations that must be given to children include the Diphtheria Pertussis Tetatus-Hepatitis B-Hemophilus Influenza type B vaccine or better known as Pentabio DPT. The DTwP / HB / HiB vaccine is given to babies in 3 doses at 1 month intervals. This immunization caused a systemic reaction, one of which was a fever of 0.85% in the first 30 minutes and increased to 14.03% on the day after immunization. The purpose of this study was to determine the effectiveness of shallots (Allium ascalonicum L) in reducing the body temperature of feverish children after Pentabio DPT immunization. This type of research was quasi-experimental study, with pre and post test with control group design. The sample in this study were babies who received DPT immunization as many as 20 respondents. DPT Pentabio immunization was given a dose of 0.5 ml in the intervention group and the control group. The statistical test used was the T test. The results showed that there was a significant effect of shallots on in reducing the body temperature of feverish children after Pentabio DPT immunization, with a p-value of 0.000.
Keywords: shallots; body temperature; fever; Pentabio DPT immunization

ABSTRAK

Imunisasi yang wajib diberikan kepada anak-anak diantaranya adalah vaksin Diphtheria Pertusis Tetatus-Hepatitis B-Hemophilus Influenza type B atau lebih dikenal dengan DPT Pentabio. Vaksin DTwP/HB/HiB diberikan kepada bayi sebanyak 3 dosis dengan interval 1 bulan. Imunisasi ini menimbulkan reaksi sistemik salah satunya berupa demam 0,85% pada 30 menit pertama dan meningkat menjadi 14,03% pada satu hari pasca imunisasi. Tujuan dari penelitian ini adalah mengetahui efektifitas bawang merah (Allium ascalonicum L) terhadap penurunan suhu tubuh anak demam pasca imunisasi DPT Pentabio. Jenis penelitian quasi eksperimen dengan pre and post test with control group design. Sampel pada penelitian ini adalah bayi yang mendapat imunisasi DPT sebanyak 20 orang responden. Pemberian imunisasi DPT PENTABIO Pentabio dosis 0,5 ml pada kelompok intervensi dan kelompok kontrol. Uji statistik yang digunakan adalah Uji T. Hasil penelitian menunjukkan ada pengaruh yang signifikan dari bawang merah dalam menurunkan suhu tubuh anak demam pasca imunisasi DPT Pentabio, dengan p-value 0,000.
Kata kunci: bawang merah; suhu tubuh; demam; imunisasi DPT Pentabio
New-Onset Atrial Fibrillation in Patients With Primary Aldosteronism Receiving Different Treatment Strategies: Systematic Review and Pooled Analysis of Three Studies
Authors: Tsai Cheng-Hsuan , Chen Ya-Li , Pan Chien-Ting , Lin Yen-Tin , Lee Po-Chin , Chiu Yu-Wei , Liao Che-Wei , Chen Zheng-Wei , Chang Chin-Chen , Chang Yi-Yao , Hung Chi-Sheng , Lin Yen-Hung 
Published: May 2021

BackgroundPrimary aldosteronism (PA) is a common cause of secondary hypertension and associated with higher incidence of new-onset atrial fibrillation (NOAF). However, the effects of surgical or medical therapies on preventing NOAF in PA patents remain unclear. The aim of this meta-analysis study was to assess the risk of NOAF among PA patients receiving mineralocorticoid receptor antagonist (MRA) treatment, PA patients receiving adrenalectomy, and patients with essential hypertension.MethodsWe performed the meta-analysis of the randomized or observational studies that investigated the incidence rate of NOAF in PA patients receiving MRA treatment versus PA patients receiving adrenalectomy from database inception until December 01, 2020 which were identified from PubMed, Embase, and Cochrane Library.ResultsA total of 172 related studies were reviewed, of which three fulfilled the inclusion criteria, including a total of 2,705 PA patients. The results of meta-analysis demonstrated a higher incidence of NOAF among the PA patients receiving MRA treatment compared to the PA patients receiving adrenalectomy (pooled odds ratio [OR]: 2.83, 95% confidence interval [CI]: 1.76–4.57 in the random effects model, I2 = 0%). The pooled OR for the PA patients receiving MRA treatment compared to the patients with essential hypertension was 1.91 (95% CI: 1.11–3.28). The pooled OR for the PA patients receiving adrenalectomy compared to the patients with essential hypertension was 0.70 (95% CI: 0.28–1.79).ConclusionCompared to the essential hypertension patients and the PA patients receiving adrenalectomy, the patients with PA receiving MRA treatment had a higher risk of NOAF.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42021222022.
Comparative Immunomodulatory Evaluation of the Receptor Binding Domain of the SARS-CoV-2 Spike Protein; a Potential Vaccine Candidate Which Imparts Potent Humoral and Th1 Type Immune Response in a Mouse Model
Authors: Shrivastava Tripti , Singh Balwant , Rizvi Zaigham Abbas , Verma Rohit , Goswami Sandeep , Vishwakarma Preeti , Jakhar Kamini , Sonar Sudipta , Mani Shailendra , Bhattacharyya Sankar , Awasthi Amit , Surjit Milan 
Published: May 2021

The newly emerged novel coronavirus, SARS-CoV-2, the causative agent of COVID-19 has proven to be a threat to the human race globally, thus, vaccine development against SARS-CoV-2 is an unmet need driving mass vaccination efforts. The receptor binding domain of the spike protein of this coronavirus has multiple neutralizing epitopes and is associated with viral entry. Here we have designed and characterized the SARS-CoV-2 spike protein fragment 330-526 as receptor binding domain 330-526 (RBD330-526) with two native glycosylation sites (N331 and N343); as a potential subunit vaccine candidate. We initially characterized RBD330-526 biochemically and investigated its thermal stability, humoral and T cell immune response of various RBD protein formulations (with or without adjuvant) to evaluate the inherent immunogenicity and immunomodulatory effect. Our result showed that the purified RBD immunogen is stable up to 72 h, without any apparent loss in affinity or specificity of interaction with the ACE2 receptor. Upon immunization in mice, RBD generates a high titer humoral response, elevated IFN-γ producing CD4+ cells, cytotoxic T cells, and robust neutralizing antibodies against live SARS-CoV-2 virus. Our results collectively support the potential of RBD330-526 as a promising vaccine candidate against SARS-CoV-2.
SARS-CoV-2-Specific Antibody Prevalence and Symptoms in a Local Austrian Population
Authors: Ladage Dennis , Höglinger Yana , Ladage Dorothee , Adler Christoph , Yalcin Israfil , Harzer Oliver , Braun Ralf J. 
Published: May 2021

Background: Since December 2019 the novel coronavirus (SARS-CoV-2) is the center of global attention due to its rapid transmission and toll on health care systems and global economy. Population-based serosurveys measuring antibodies for SARS-CoV-2 provide one method for estimating previous infection rates including the symptom-free courses of the disease and monitoring the progression of the epidemic.Methods: In June 2020 we succeeded in testing almost half of the population of an Austrian township (1,359 inhabitants) with a reported higher incidence for COVID-19 infections (17 PCR positive cases have been officially reported until the date of sample collection, i.e., 1.2% of the total population). We determined the prevalence of SARS-CoV-2-specific antibodies in this population, factors affecting, and symptoms correlated with prior infection. Antibodies were determined using a CE-certified quality-controlled ELISA test for SARS-CoV-2-specific IgG and IgA antibodies.Results: We found a high prevalence of 9% positive antibodies among the town population in comparison to 6% of the neighboring villages. This was considerably higher than the officially known RT-PCR-approved COVID-19 cases (1.2%) in the town population. Twenty percent of SARS-CoV-2-antibody positive cases declared being asymptomatic in a questionnaire. On the other hand, we identified six single major symptoms, including anosmia/ageusia, weight loss, anorexia, general debility, dyspnea, and fever, and especially their combination to be of high prognostic value for predicting SARS-CoV-2 infection in a patient.Conclusions: This population study demonstrated a high prevalence of antibodies to SARS-CoV-2 as a marker of past infections in an Austrian township. Several symptoms revealed a diagnostic value especially in combination.
Dietary Intake of Vegetables and Cooking Oil Was Associated With Drug-Induced Liver Injury During Tuberculosis Treatment: A Preliminary Cohort Study
Authors: Wang Jinyu , Xiong Ke , Xu Lei , Zhang Chao , Zhao Shanliang , Liu Yufeng , Ma Aiguo 
Published: May 2021

Background and Purpose: Drug-induced liver injury is challenging during tuberculosis treatment. There is no epidemiological data investigating the relation between dietary intake and the risk of drug-induced liver injury during tuberculosis treatment. The aim of this study is to investigate the association of food and nutrient intake with the incidence of tuberculosis-drug-induced liver injury.Methods: A cohort study was conducted in two city-level tuberculosis-specialized hospitals in Linyi City and Qingdao City, China from January 2011 to December 2013. The dietary intake was assessed by a 3-day 24-h food recall survey and a standard food-frequency questionnaire. The liver functions including aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were monitored throughout the 6-month tuberculosis therapy. Liver injury was defined as ALT or AST higher than two times of the upper limit of normal (ULN). Liver dysfunction was defined as ALT or AST higher than the ULN. The ULN for ALT and AST is 40 U/L. Multivariate logistic regression analyses were performed to determine the dietary factors associated with the incidence of liver injury and liver dysfunction.Results: A total of 605 patients were included in the analysis. During the treatment, 8.1% patients exhibited liver injury and 23.3% patients exhibited liver dysfunction. A lower intake of vegetables was associated with a higher risk of liver injury [OR (95% CI): 3.50 (1.52–8.08), P = 0.003) and liver dysfunction [OR (95% CI): 2.37 (1.31–4.29), P = 0.004], while a lower intake of cooking oil was associated with a lower risk of liver injury [OR (95% CI): 0.44 (0.20–0.96), P = 0.040)] and liver dysfunction [OR (95% CI): 0.51 (0.31–0.85), P = 0.009].Conclusion: The current study indicated that the higher risks of tuberculosis-drug-induced liver injury and liver dysfunction were statistically associated with decreased vegetable intake and increased cooking oil intake.
Exploring MRI Characteristics of Brain Diffuse Midline Gliomas With the H3 K27M Mutation Using Radiomics
Authors: Li Qian , Dong Fei , Jiang Biao , Zhang Minming 
Published: May 2021

ObjectivesTo explore the magnetic resonance imaging (MRI) characteristics of brain diffuse midline gliomas with the H3 K27M mutation (DMG-M) using radiomics.Materials and MethodsThirty patients with diffuse midline gliomas, including 16 with the H3 K27M mutant and 14 with wild type tumors, were retrospectively included in this study. A total of 272 radiomic features were initially extracted from MR images of each tumor. Principal component analysis, univariate analysis, and three other feature selection methods, including variance thresholding, recursive feature elimination, and the elastic net, were used to analyze the radiomic features. Based on the results, related visually accessible features of the tumors were further evaluated.ResultsPatients with DMG-M were younger than those with diffuse midline gliomas with H3 K27M wild (DMG-W) (median, 25.5 and 48 years old, respectively; p=0.005). Principal component analysis showed that there were obvious overlaps in the first two principal components for both DMG-M and DMG-W tumors. The feature selection results showed that few features from T2-weighted images (T2WI) were useful for differentiating DMG-M and DMG-W tumors. Thereafter, four visually accessible features related to T2WI were further extracted and analyzed. Among these features, only cystic formation showed a significant difference between the two types of tumors (OR=7.800, 95% CI 1.476–41.214, p=0.024).ConclusionsDMGs with and without the H3 K27M mutation shared similar MRI characteristics. T2W sequences may be valuable, and cystic formation a useful MRI biomarker, for diagnosing brain DMG-M.
Targeting Mutated p53 Dependency in Triple-Negative Breast Cancer Cells Through CDK7 Inhibition
Authors: Peng Jingyu , Yang Ming , Bi Ran , Wang Yueyuan , Wang Chunxi , Wei Xue , Zhang Zhihao , Xie Xiao , Wei Wei 
Published: May 2021

BackgroundCyclin-dependent kinase 7 (CDK7) is crucial for cell cycle progression and gene expression transcriptional regulation, which are often not assessed in cancer developing process. CDK7 inhibitors have emerged as promising drugs for treating diverse cancers, including breast cancer. However, the mechanism behind its anticancer effect has not been well investigated. Here, the possible mechanism of CDK7 inhibitors for treating human triple-negative breast cancer (TNBC) has been studied.MethodsThe effects of CDK7 inhibitors on breast cancer cells have been identified by measuring cell viability (Cell Counting Kit-8) and cell proliferation and calculating colony formation. The short hairpin RNA and short interfering RNA were used for the construction of knockdown cells. To assess the expression of associated proteins, western blot was used.ResultsThis study confirmed that, compared to hormone receptor-positive breast cancer cells, TNBC cells were more sensitive to THZ1, a novel CDK7 inhibitor. THZ1 treatment specifically downregulated mutated p53 in a dose- and time-dependent manner in TNBC cells with p53 mutation. Another CDK7 inhibitor, LDC4297, also potently interfered with the expression of mutated p53. Furthermore, endogenous CDK7 expression was positively correlated with the levels of mutated p53 in TNBC cells with p53 mutation. Downregulating mutated p53 expression significantly suppressed the proliferation of TNBC cells with p53 mutation.ConclusionOur findings demonstrated that targeting CDK7 was an effective approach for the treatment of TNBC with p53 mutation.
Quantitative T2*-Weighted Imaging and Reduced Field-of-View Diffusion-Weighted Imaging of Rectal Cancer: Correlation of R2* and Apparent Diffusion Coefficient With Histopathological Prognostic Factors
Authors: Peng Yang , Luo Yan , Hu Xuemei , Shen Yaqi , Hu Daoyu , Li Zhen , Kamel Ihab 
Published: May 2021

PurposeTo assess T2*-weighted imaging (T2*WI) and reduced field-of-view diffusion-weighted Imaging (rDWI) derived parameters and their relationships with histopathological factors in patients with rectal cancer.MethodsFifty-four patients with pathologically-proven rectal cancer underwent preoperative T2*-weighted imaging and rDWI in this retrospective study. R2* values from T2*-weighted imaging and apparent diffusion coefficient (ADC) values from rDWI were compared in terms of different histopathological prognostic factors using student’s t-test or Mann-Whitney U-test. The correlations of R2* and ADC with prognostic factors were assessed by Spearman correlation analysis. The diagnostic performances of R2* and ADC were analyzed by receiver operating characteristic curves (ROC) separately and jointly.ResultsSignificant positive correlation was found between R2* values and T stage, lymph node involvement, histological grades, CEA level, the presence of EMVI and tumor deposit (r = 0.374 ~ 0.673, p = 0.000–0.006), with the exception of CA19-9 level, CRM status and tumor involvement in the circumference lumen (TIL). Meanwhile, ADC values negatively correlated with almost all the prognostic factors (r = −0.588 to −0.299, p = 0.000–0.030), except CA19-9 level. The AUC range was 0.724–0.907 for R2* and 0.674–0.887 for ADC in discrimination of different prognostic factors. While showing the highest AUC of 0.913 (0.803–1.000) in differentiation of T stage, combination of R2* and ADC with reference to different prognostic factors did not significantly improve the diagnostic performance in comparison with individual R2*/ADC parameter.ConclusionsR2* and ADC were associated with important histopathological prognostic factors of rectal cancer. R2* might act as additional quantitative imaging marker for tumor characterization of rectal cancer.