bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the need for integrating cancer into the One Health perspective
Authors: M. Dujon Antoine , Brown Joel S. , Destoumieux‐Garzón Delphine , Vittecoq Marion , Hamede Rodrigo , Tasiemski Aurélie , Boutry Justine , Tissot Sophie , Alix‐Panabieres Catherine , Pujol Pascal , Renaud François , Simard Frédéric , Roche Benjamin , Ujvari Beata , Thomas Frédéric 
Published: September 2021

SummaryRecent pandemics have highlighted the urgency to connect disciplines studying animal, human, and environment health, that is, the “One Health” concept. The One Health approach takes a holistic view of health, but it has largely focused on zoonotic diseases while not addressing oncogenic processes. We argue that cancers should be an additional key focus in the One Health approach based on three factors that add to the well‐documented impact of humans on the natural environment and its implications on cancer emergence. First, human activities are oncogenic to other animals, exacerbating the dynamics of oncogenesis, causing immunosuppressive disorders in wildlife with effects on host–pathogen interactions, and eventually facilitating pathogen spillovers. Second, the emergence of transmissible cancers in animal species (including humans) has the potential to accelerate biodiversity loss across ecosystems and to become pandemic. It is crucial to understand why, how, and when transmissible cancers emerge and spread. Third, translating knowledge of tumor suppressor mechanisms found across the Animal Kingdom to human health offers novel insights into cancer prevention and treatment strategies.
Commercial implementation of genomic selection in Tasmanian Atlantic salmon: Scheme evolution and validation
Authors: Verbyla Klara L. , Kube Peter D. , Evans Bradley S. 
Published: September 2021

AbstractGenomic information was included for the first time in the prediction of breeding values for Atlantic salmon within the Australian Salmon Enterprises of Tasmania Pty Ltd selective breeding program in 2016. The process to realize genomic selection in the breeding program begun in 2014 with the scheme finalized and fully implemented for the first time in 2018. The high potential of within family selection to accelerate genetic gain, something not possible using the traditional pedigree‐based approach, provided the impetus for implementation. Efficient and effective genotyping platforms are essential for genomic selection. Genotype data from high density arrays revealed extensive persistence of linkage disequilibrium in the Tasmania Atlantic salmon population, resulting in high accuracies of both imputation and genomic breeding values when using imputed data. Consequently, a low‐density novel genotype‐by‐sequence assay was designed and incorporated into the scheme. Through the use of a static high‐ and dynamic low‐density genotyping platforms, an optimized genotyping scheme was devised and implemented such that all individuals in every year class are genotyped efficiently while maximizing the genetic gains and minimizing costs. The increase in the rates of genetic gain attributed to the implementation of genomic selection is significant across both the breeding programs primary and secondary traits. Substantial improvement in the ability to select parents prior to progeny testing is observed across multiple years. The resultant economic impacts for the industry are considerable based on the increases in genetic gain for traits achieved within the breeding program and the use of genomic selection for commercial production.
Recovery of horses from general anaesthesia: A systematic review (2000‐2020) of risk factors and influence of interventions during the recovery period
Authors: Loomes Kate , Louro Luís Filipe 
Published: September 2021

AbstractBackgroundIn equine anaesthesia, the recovery period is a time of considerable risk and has been the focus of prolific research. Risk factors, including age, type and duration of procedure or temperament may influence recovery quality. Unfortunately, the anaesthetist is unable to control for these factors, therefore various pharmacological interventions and recovery methods have been developed with the objective of improving recovery quality. However, no consensus among anaesthetists has been reached for many of these interventions and their implications for recovery‐related mortality and morbidity.ObjectivesTo conduct a systematic review of the published evidence relating to risk factors and interventions in the recovery period which may influence recovery quality from equine general anaesthesia (GA).Study designA systematic evaluation of the equine veterinary literature using the GRADE framework.MethodsA literature search was performed and studies were assessed for eligibility by both authors utilising PRISMA guidelines. Studies meeting inclusion criteria were evaluated by both authors, categorically summarised and the quality of evidence for each sub‐topic was assessed using the GRADE framework.ResultsThirty‐nine studies were identified which directly assessed the impact of risk factors and recovery interventions on recovery quality after equine GA. There was evidence to support that peri‐anaesthetic risk factors such as anaesthesia duration, American Society of Anesthesiologists (ASA) physical status and surgical procedure influenced recovery quality. We also identified sufficient evidence that administration of α‐2 adrenoreceptor agonists immediately prior to recovery, improves recovery quality.Main limitationsThe validity of the results of some studies may have been compromised by missing data and small sample sizes.ConclusionsRecovery quality is influenced by factors including: anaesthesia duration, ASA physical status and surgical procedure. Recovery quality can be improved by the administration of an α‐2 adrenoreceptor agonist immediately prior to recovery.
Extracting low dimensional representations from large size whole slide images using deep convolutional autoencoders
Authors: Çelik Yusuf , Karabatak Murat 
Published: September 2021

AbstractBackground and objectiveArtificial intelligence‐based analysis of medical images has recently become a trendy field of study. The most significant effect on these systems to produce reliable and high‐performance results is the amount of accessed data. Although whole‐slide images (WSI), one of the current imaging techniques used in histopathology, storage costs are very expensive. Therefore, low‐dimensional visuals representing of WSIs is an essential field of study.MethodsIn this study, deep auto‐encoder‐based models are designed to create low dimensional representations for WSI. The size reduction was performed for the input images in different sizes, at the ratios of 1: 3, 1: 6, and 1: 12, respectively.ResultsSimilarity index measure values were obtained as high as 0.957 and 0.938, respectively, using 128 × 128 × 3 dimensional patches in the size reduction process of 1: 3 and 1:12 on test WSI.ConclusionThe proposed model has a structure that can be applied in compression of WSIs and secure data transfer. By using these representations, both storage costs and the high‐level hardware costs required by deep learning algorithms can be significantly reduced.
Academic mothers, professional identity and COVID‐19: Feminist reflections on career cycles, progression and practice
Authors: Bowyer Dorothea , Deitz Milissa , Jamison Anne , Taylor Chloe E. , Gyengesi Erika , Ross Jaime , Hammond Hollie , Ogbeide Anita Eseosa , Dune Tinashe 
Published: September 2021

AbstractBased on a collection of auto‐ethnographic narratives that reflect our experiences as academic mothers at an Australian university, this paper seeks to illustrate the impact of COVID‐19 on our career cycles in order to explore alternative feminist models of progression and practice in Higher Education. Collectively, we span multiple disciplines, parenting profiles, and racial/ethnic backgrounds. Our narratives (initiated in 2019) explicate four focal points in our careers as a foundation for analyzing self‐definitions of professional identity: pre‐ and post‐maternity career break; and pre‐ and post‐COVID‐19 career. We have modeled this research on a collective feminist research practice that is generative and empowering in terms of self‐reflective models of collaborative research. Considering this practice and these narratives, we argue for a de‐centering of masculinized career cycle patterns and progression pathways both now and beyond COVID‐19. This represents both a challenge to neo‐liberal norms of academic productivity, as well as a call to radically enhance institutional gender equality policies and practice.
Evaluation of the sexual health in people living with hemophilia
Authors: Germini Federico , Chai‐Adisaksopha Chatree , Pete Drashti , Curtis Randall , Frick Neil , Nichol Michael B. , Noone Declan , O'Mahony Brian , Page David , Stonebraker Jeffrey S. , Thabane Lehana , Crowther Mark A , Skinner Mark W , Iorio Alfonso 
Published: September 2021

AbstractBackgroundKnowledge about sexual health, difficulty with sexual activity and intimacy (sexual difficulty), in people with hemophilia is little understood.ObjectivesThe objectives were to determine the prevalence of sexual difficulty in people living with hemophilia (PWH) compared to people with no bleeding disorders (PWNoBD), and to determine factors associated with it.MethodsThis was an analysis of the PROBE study. We recruited individuals who had hemophilia A or B (PWH) and PWNoBD who were 18 years old or older. We calculated proportions of participants with sexual difficulty and odds ratios (ORs) adjusted for sex and age with 95% confidence intervals.ResultsThere were 2007 PWH and 1972 PWNoBD. Mean (standard deviation) age was 41 (15) years in PWH and 42 (13) years in PWNoBD. Sexual difficulty was reported in 302 (15.1%) PWH and 79 (4.0%) PWNoBD. The odds of sexual difficulty were significantly higher in PWH (OR 3.82, 95% CI 2.85, 5.11). Among PWH, older age, experiencing acute or chronic pain in the past 12 months, bleeds within the past two weeks, ≥3 spontaneous joint bleeds (past six months), limitation of range of motion of any joints, and any life‐ or limb‐threatening bleeds in the past 12 months were associated with sexual difficulty.ConclusionsSexual difficulty is more prevalent in people living with hemophilia and associated with markers of disease severity. Sexual health issues should be incorporated in comprehensive hemophilia care, future research, and hemophilia related health policy.
Bleeding with iron deposition and vascular remodelling in subchondral cysts: A newly discovered feature unique to haemophilic arthropathy
Authors: Zhou Jenny Y. , Wong Jonathan H. , Berman Zachary T. , Lombardi Alecio F. , Chang Eric Y. , von Drygalski Annette 
Published: September 2021

AbstractIntroductionJoint iron accumulation is the incendiary factor triggering osteochondral destruction, synovial hypertrophy, inflammation, and vascular remodelling in haemophilic arthropathy (HA). Hemosiderin depositions have been described in synovium and, more recently, in cartilage. Clinical observations also suggest hemosiderin accumulation in subchondral cysts, implying cyst bleeding.AimWe explored associations between cystic iron accumulation, vascular remodelling and HA status to determine if cystic bleeding may contribute to HA progression.MethodsThirty‐six haemophilic joints (16 knees, 10 ankles, and 10 elbows; 31 adult patients with haemophilia A/B) were evaluated by magnetic resonance imaging (MRI) for subchondral cysts and hemosiderin. Cyst score (WORMS) and hemosiderin presence were compared between haemophilic and osteoarthritic knees, matched for the degree of arthritis (Kellgren‐Lawrence score). Cystic iron accumulation, vascular remodelling and macrophage cell counts were also compared by immunohistochemistry in explanted joint tissues. In haemophilic knees, cyst number and extent of hemosiderin deposition were correlated with haemophilia joint health scores (HJHS).ResultsCystic hemosiderin was detected in 78% of haemophilic joints. Cyst score and presence of hemosiderin were significantly higher in haemophilic compared to osteoarthritic knees. Cyst score and presence of hemosiderin strongly correlated with HJHS. Moreover, iron deposition and vascular remodelling were significantly more pronounced within cysts in haemophilic compared to osteoarthritic knees, with similar total cell and macrophage count.ConclusionThese findings suggest the presence of subchondral bleeding in haemophilia, contributing to poor joint health outcomes. Observations of bleeding into osseous structures are novel and should inform investigations of new therapies.
Improving corrosion protection of Mg alloys (AZ31B) using graphene‐based hybrid coatings
Authors: Afsharimani Nasima , Talimian Ali , Merino Emilia , Durán Alicia , Castro Yolanda , Galusek Dusan 
Published: September 2021

AbstractIn the present work, a study was carried out to compare the morphology and electrochemical properties of pure and graphene‐modified hybrid silica sol–gel coatings deposited on anodized AZ31B magnesium alloys. The precursor solution was prepared using tetraethoxysilane (TEOS) and 3‐glycidoxypropyl‐trimethoxysilane (GPTMS), with the addition of chemically modified graphene nanosheets (GN‐chem). Homogeneous and adherent coatings were obtained using GPTMS‐TEOS (GT) and GPTMS‐TEOS‐GN‐chem (GT/GN‐chem) solutions with uniform thickness around 4 µm. Raman, SEM images and EDS analyses confirmed the presence of graphene nanosheets in the coatings. Potentiodynamic polarization results using 0.05 M NaCl electrolyte solution showed that graphene containing silica coatings significantly improve the corrosion resistance of AZ31B alloys. In addition, a significant passive region was observed for GT/GN‐chem coatings.
Effects of different saccharides on the microstructure and functional properties of protein in goat milk during processing
Authors: Wang Linlin , Wang Cunfang , Zhang Xiaoning , Fan Xiaoxue , Shao Xiaoqing 
Published: September 2021

AbstractThis study investigated the changes in the characteristics of goat milk protein in the presence of trehalose, chitooligosaccharide and pectin during two practical dairy processing operations of pasteurisation and spray drying. The highest denaturation temperature and the largest particle size of milk protein were found in goat milk added with pectin after pasteurisation. And particles with more uniform and compact morphology were observed in goat milk protein with these three saccharides. An elevated emulsifying activity index of 24.37 m/g−2 was observed in protein after spray drying due to chitooligosaccharide. And the foam stability was also improved significantly in the presence of trehalose and pectin during pasteurisation. During spray drying, saccharides showed the stabilizing effect on goat milk protein. This study revealed a complex interplay between the type of saccharides and the processing operation applied to goat milk, which might be of great significance for the production and processing of goat milk.
A holocenic and dynamic hybrid zone between two cactophilicDrosophilaspecies in a coastal lowland plain of the Brazilian Atlantic Forest
Authors: Barrios‐Leal Dora Yovana , Menezes Rodolpho S. T. , Ribeiro João Victor , Bizzo Luiz , Melo de Sene Fabio , Neves‐da‐Rocha João , Manfrin Maura Helena 
Published: September 2021

AbstractHybridization and introgression are processes that contribute to shaping biological diversity. The factors promoting the formation of these processes are multiples but poorly explored in a biogeographical and ecological context. In the southeast coastal plain of the Brazilian Atlantic Forest, a hybrid zone was described between two closely related cactophilic species,Drosophila antonietaeandD.serido. Here, we revisited and analysed specimens from this hybrid zone to evaluate its temporal and spatial dynamic. We examined allopatric and sympatric populations of the flies using independent sources of data such as mitochondrial and nuclear sequences, microsatellite loci, morphometrics of wings and male genitalia, and climatic niche models. We also verified the emergence of the flies from necrotic tissues of collected cacti to verify the role of host association for the population dynamics. Our results support the existence of a hybrid zone due to secondary contact and limited to the localities where the two species are currently in contact. Furthermore, we detected asymmetric bidirectional introgression and the maintenance of the species integrity, ecological association and morphological characters, suggesting selection and limited introgression. Considering our paleomodels, probably this hybrid zone is recent and the contact occurred during the Holocene to the present day, favoured by range expansion of their populations due to expansion of open and dry areas in eastern South America during palaeoclimatic and geomorphological events.
Molecular signatures from multi‐omics of autism spectrum disorders and schizophrenia
Authors: Nomura Jun , Mardo Matthew , Takumi Toru 
Published: September 2021

AbstractThe genetic and phenotypic heterogeneity of autism spectrum disorder (ASD) impedes the unification of multiple biological hypotheses in an attempt to explain the complex features of ASD, such as impaired social communication, social interaction deficits, and restricted and repetitive patterns of behavior. However, recent psychiatric genetic studies have identified numerous risk genes and chromosome loci (copy number variation: CNV) which enable us to analyze at the single gene level and utilize system‐level approaches. In this review, we focus on ASD as a major neurodevelopmental disorder and review recent findings mainly from the bioinformatics of omics studies. Additionally, by comparing these data with other major psychiatric disorders, including schizophrenia (SCZ), we identify unique characteristics of both diseases from multiple enrichment, pathway, and protein–protein interaction networks (PPIs) analyses using susceptible genes found in recent large‐scale genetic studies. These unified, systematic approaches highlight unique characteristics of both disorders from multiple aspects and demonstrate how convergent pathways can contribute to an understanding of the complex etiology of such neurodevelopmental and neuropsychiatric disorders.
image
Vitamin D, respiratory infections, and chronic disease: Review of meta‐analyses and randomized clinical trials
Authors: Ganmaa Davaasambuu , Enkhmaa Davaasambuu , Nasantogtokh Erdenebileg , Sukhbaatar Surenmaa , Tumur‐Ochir Khash‐Erdene , Manson JE 
Published: September 2021

AbstractBackgroundObservational studies have suggested associations of vitamin D deficiency (VDD) with respiratory tract infections, impaired bone health, and myriad chronic diseases.Objective To assess potential causal relationships between vitamin D supplementation and a reduced risk of these conditions, a review of the evidence across available meta‐analyses of randomized control trials (RCTs) and RCTs was performed.Method PubMed, Embase, Cochrane Library, and Web of Science were searched from their inception to March 2021. We included only RCTs and meta‐analyses of RCTs focusing on the association between vitamin D and respiratory disease, bone health, cardiovascular disease (CVD), diabetes mellitus, and cancer.Results A total of 107 RCTs and 62 meta‐analysis of RCTs were included. Although most RCTs did not support benefits of vitamin D supplementation, suggestive evidence for benefit was found in populations at greater risk of VDD and for acute respiratory infections, fractures in institutionalized older adults, type 2 diabetes among patients with prediabetes, and cancer mortality. In contrast, no compelling evidence for benefit was found for other respiratory conditions, fractures in community‐dwelling adults, falls, cancer incidence, or CVD.Conclusions Current evidence from RCTs and meta‐analyses of RCTs is inconsistent regarding the effects of vitamin D supplementation on respiratory infections and chronic diseases. Individuals most likely to benefit are those with baseline VDD or with selected high‐risk conditions. Public health initiatives are needed to eliminate VDD globally, and future research will be enhanced by a ‘precision prevention’ approach to identify those most likely to benefit from vitamin D supplementation.
Optic nerve sheath diameter measurement by ultrasound: Evaluation of a standardized protocol
Authors: Pansell Jakob , Bell Max , Rudberg Peter , Friman Ola , Cooray Charith 
Published: September 2021

AbstractBackground and PurposeTreatment of elevated intracranial pressure (ICP) is central to neurocritical care, but not all patients are eligible for invasive ICP‐monitoring. A promising noninvasive option is ultrasound measurement of the optic nerve sheath diameter (ONSD). However, meta‐analyses of ONSD for elevated ICP show wide confidence intervals. This might be due to baseline variations, inter‐rater variability, and varying measurement methods. No standardized protocol has been validated. Corrections for eyeball diameter (ED) and optic nerve diameter (OND) may compensate for baseline variations. We evaluated a protocol and compared two different measurement methods for ONSD ultrasound.MethodsTwo operators, blinded to each other's measurements, measured ONSD, ED, and OND twice in 20 patients. ONSD was measured with two different methods in use: internal (ONSDint) or external (ONSDext) of the dura mater. Intra‐class correlation (ICC) was calculated for inter‐rater and intra‐rater reliability.ResultsICCs for inter‐rater reliability of ONSDext and ONSDint (95% confidence interval) were 0.96 (0.93, 0.98) and 0.88 (0.79, 0.94), respectively. ICCs for intra‐rater reliability of ONSDext and ONSDint were 0.97 (0.94, 0.99) and 0.93 (0.87, 0.96), respectively. There was no significant bias or difference in intra‐rater reliability between operators.ConclusionsONSD can be measured with an excellent inter‐ and intra‐rater reliability and low risk of inter‐rater bias, when using this protocol. ONSDext yields a higher inter‐ and intra‐rater reliability than ONSDint. Corrections for ED and OND can be performed reliably.