bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of Precision Medical Technology and its Current Clinical Applications
Authors: Gao Kaiye , Wang Ziwen , Chi Yuanying , Peng Rui 
Published: June 2021

Background:
Precision medicine has emerged with the development of science and technology
and the rise of big data. This study first defines and presents the advantages of precision
medicine and then introduces the development of three technologies: gene sequencing, cellular immunotherapy,
and gene editing. The clinical applications of precision medicine in lung cancer, cervical
cancer, breast cancer, and prostate cancer are thus analyzed. Lastly, the existing problems and
future development directions of precision medicine are identified. The introduction of gene sequencing,
bioanalytical techniques, and big data analysis tools has propelled medicine into the era of
precision medicine. Key technologies in precision medicine form the foundation of its development.
Therefore, this study elaborates on the development of key technologies in precision medicine, the
current status of its clinical application, and the main problems that currently exist. This study also
suggests solutions to the problems.

Objective:
To systematically explain the development and principle of three core technologies in
precision medicine and to predict the main research trends of precision medicine.

Results:
Research in gene sequencing, cell immunotherapy, and gene editing technology has shown
significant progress, and accurate medical treatment has achieved remarkable results, effectively
prolonging the survival time and improving the quality of life of patients.

Conclusion:
Precision medicine has made significant achievements, but problems remain. Ensuring
safety and efficiency in precision medicine should be the focus of future research.
Digital Self-Management Support Tools in the Care Plan of Patients With Cancer: Review of Randomized Controlled Trials
Authors: Adriaans Danielle JM , Dierick-van Daele Angelique TM , van Bakel Marc Johannes Hubertus Maria , Nieuwenhuijzen Grard AP , Teijink Joep AW , Heesakkers Fanny FBM , van Laarhoven Hanneke WM 
Published: June 2021

Background
Digital self-management support tools (DSMSTs)—electronic devices or monitoring systems to monitor or improve health status—have become increasingly important in cancer care.

Objective
The aim of this review is to analyze published randomized clinical trials to assess the effectiveness of DSMSTs on physical and psychosocial symptoms or other supportive care needs in adult patients with cancer.

Methods
Five databases were searched from January 2013 to January 2020. English or Dutch language randomized controlled trials comparing DSMSTs with no intervention, usual care, alternative interventions, or a combination and including patients aged ≥18 years with pathologically proven cancer in the active treatment or survivorship phases were included. The results were summarized qualitatively.

Results
A total of 19 publications describing 3 types of DSMSTs were included. Although the content, duration, and frequency of interventions varied considerably across studies, the commonly used elements included an assessment component, tailored symptom self-management support, an information section, a communication section, and a diary. Significant positive effects were observed on quality of life in 6 (out of 10) studies, on anxiety in 1 (out of 5) study and depression in 2 (out of 8) studies, on symptom distress in 5 (out of 7) studies, on physical activity in 4 (out of 6) studies, on dietary behavior in 1 (out of 4) study, and on fatigue in 2 (out of 5) studies. Moreover, significant negative effects were observed on anxiety in 1 (out of 5) study and depression in 1 (out of 8) study. Most interventions were web-based interventions; 2 studies used mobile apps, and 1 study used a game as a DSMST. The overall quality of the studies was found to be good, with 13 out of 19 studies classified as high quality.

Conclusions
This review suggests that DSMSTs have a beneficial effect on the quality of life. For effects on other patient outcomes (eg, anxiety and depression, symptom distress, physical activity, dietary behavior, and fatigue), the evidence is inconsistent and limited or no effect is suggested. Future research should focus on specific tumor types, study different types of interventions separately, and assess the effects of specific interventions at different stages of disease progression.
Pola komunikasi organisasi pustakawan-guru dalam pemberian layanan prima perpustakaan
Authors: Rachmawati Tine Silvana , Agustine Merryam 
Published: June 2021

Introduction. The purpose of this study is to examine the organizational communication patterns between librarians and teachers in providing quality library services.
Data Collection Method. This is a qualitative research with a case study approach with librarians and teachers as samples. Data collection techniques were interviews, observations, and literature study.
Data Analysis. Data analysis techniques were conducted by reducing data, presenting data, and then making conclusions or data verification.
Results and Discussion. The results of this study indicate that a well-established organizational communication pattern between librarians and teachers consists of task coordination, problem-solving, information sharing, conflict resolution, and building togetherness or relationships. All of them supported excellent services.
Conclusion. Librarian who implement a good horizontal organizational communication model can provide high-quality services to teachers who need information, which is beneficial to the library and the school as an organization. The recommendation of this study is that schools should be able to treat librarians as key people in organizing ideas and information resources, rather than as only as academic supporters.
Faktor penyebab rendahnya pemanfaatan jurnal elektronik di Perpustakaan Universitas Gadjah Mada oleh mahasiswa Sekolah Pascasarjana
Authors: Handayani Fitri 
Published: June 2021

Introduction. This study aims to examine the inhibiting factors of the use of electronic journals atthe Universitas Gadjah Mada (UGM) Library by UGM graduate school students. The study used Weber's information system model theory with the following variables: system quality, information quality, user training, perceived usefulness, perceived ease of use, computer self-efficacy, information system use, individual impact and information system satisfaction.
Data Collection Methods. This study used surveys with a quantitative approach. and observations.
Results and Discussion. The results of this study showed that the inhibiting factors of electronic journals at the UGM Library was the difficulties in using information systems electronic journals. This resulted that the students were less confident and rarely to access and utilize electronic journals due to their lack of understanding and skilss in using computers or e-Journal information system.
Conclusion. The low utilization of the electronic journal is related to the quality of information system (system quality), user perceived difficulties when accessing the electronic journal Information system (perceived easy of use) and the user's ability to use the computer (computer self-efficacy).
PHARMACOECONOMIC EVALUATION OF ANTIDIABETIC THERAPY AT A TERTIARY HEALTH CARE INSTITUTION
Authors: M ANIRUDH , K KARTHIKEYAN 
Published: June 2021

Objective: The present study was aimed to estimate the direct cost of pharmacotherapy, laboratory tests, and medical tests incurred by patients, to analyze the health-related quality of life (HRQoL) for diabetic patient with macrovascular complications, to estimate the direct health system costs of treating patients with diabetes, to analyze the drug utilization trend of anti-diabetic therapy, to estimate the annual total direct medical costs of managing patients with diabetes, and to evaluate pharmacoeconomic impact on outcomes or beneficence of diabetic therapy.
Methods: A prospective cross-sectional study at SRM Medical College, Hospital and Research Centre, Kattankulathur – General Medicine Department with a sample size of 200 patients.
Results: During study, 200 diabetic patients were enrolled based on the inclusion and exclusion criteria at SRM Medical College and Hospital. Out of 200 diabetic patients (100%), 83 (41.5%) patients were females, and 117 (58.5%) patients were males. Out of 200 (100%) diabetic patients, 18 (9%) of the patient were within the age group of 20–39 years, 78 (39%) of the patients were within the age range of 40–59, the group with the highest frequency was aged from 60 to 79 with 93 (46.5%) patients while the age group of 80–99 had the lowest frequency of 11 (5.5%) of patients. The patient sample had 14 (7%) type 1 diabetic patients out of which two patients (14.3%) were females and 12 (85.7%) were males. A total of 186 (93%) patients had type 2 diabetes where 81 (43.5%) were females and 105 (56.5%) were males. Drug utilization trend: In the patient sample, anti-diabetic drugs were the most frequently used. Oral and parenteral dosage forms were used which included insulin administration subcutaneously and intravenously together with intravenous fluids to correct cases of hyperglycemia and hypoglycemia. HRQoL is the measure of patient value in terms of impact of disease and its treatment on physical functioning and psychological well-being. Out of 200 patients, 25% had severe problems with mobility.
Conclusion: Diabetes is characterized by a very high-cost burden. Education on the prevention and management of diabetes must be prioritized. It must be provided to the diabetic patients and the society at large. Therefore, it is suggested that health-care providers and policy-makers must put more attention to the factors that result in an increased hospital care. A lower financial burden on patients would greatly increase the treatment compliance, complications, and comorbidity progression. This will result in a reduction of diabetes economic burden on patients, society, and health-care system. Further multicenter studies can be carried out in a larger population in different geographical regions in India or it can be done at a national scale.
CONSCIOUSNESS AND PRECAUTIONARY HABIT RELATING TO COVID-19 INFECTIONS AMONG STUDENTS IN NWAFOR ORIZU COLLEGE OF EDUCATION, NSUGBE
Authors: STELLA NWANKWO NONYELUM 
Published: June 2021

Objective: Similar to outbreaks of many other infectious diseases, success in controlling the novel coronavirus infection requires a timely and accurate monitoring of the epidemic. The main objective of the present study is to assess consciousness and precautionary habit relating to COVID-19 infections among students.
Methods: The descriptive survey research design method was used. The researcher formulated two research questions. A self-developed questionnaire was adopted for data collection. The sample size consists of students in Nwafor Orizu College of Education, Nsugbe, selected using purposive random sampling technique, subsequently, thirty copies of the questionnaire were administered by the researcher. Mean and standard deviation were used to analyze the data.
Results: The study showed among other findings that students are conscious about the possibility of the disease transmission by droplets when an infected person cough, sneezes, or speaks. These findings have the vantage of providing the researchers, government, students, policy makers, and government with adequate and correct baseline data on consciousness and precautionary habit relating to COVID-19 infections among students.
Conclusion: Based on the research findings, it was concluded that the world has a long history of successful efforts to prevent or cure widespread infections. The main points in preventing the spread in society are hand hygiene, social distancing, and quarantine. With increased testing capacity, detecting more positive patients in the community will also enable the reduction of secondary cases with stricter quarantine rules.
Conjugated estrogen is an effective option to manage chronic GI bleeding in a patient with atrial fibrillation and end-stage renal disease
Authors: Compton Matthew T , Patel Krupa 
Published: June 2021

A clinical decision report appraising:
Livio M, Mannucci PM, Viganò G, Mingardi G, Lombardi R, Mecca G, Remuzzi G. Conjugated estrogens for the management of bleeding associated with renal failure. N Engl J Med. 1986;315:731-735 https://doi.org/10.1056/NEJM198609183151204
for a patient with chronic GI bleeding and complicated pro- and anti-coagulation needs.
CASH MANAGEMENT: HOW DO COUNTRIES PERFORM SOUND PRACTICES?
Authors: Cangoz Coskun , Secunho Leandro 
Published: June 2021

Cash management is simply defined as making the right amount of money available at the right time and the right place to meet the government's obligations in the most cost-effective way. The main features of modern cash management are centralized government bank accounts and establishment of a Treasury Single Account, ability to make accurate cash flow forecasts, use of short-term financing instruments, and capacity for the investment of excess cash reserves. Establishing a sound cash management framework with the mentioned features is beneficial not only to the governments and public entities, but also to other stakeholders including the beneficiaries of government payments, banks and lenders. Given the recent COVID-19 (coronavirus) pandemic and locked-down measures introduced in many countries, governments had to deal with unanticipated revenue decreases, and significantly increased public expenditures due to fiscal stimulus packages and pandemic related health expenditures. Therefore, existence of a well-structured government cash management is now even more important than before. This paper aims to explore cash flow forecasting and cash management practices in 24 countries in various regions, at different income levels and technical capacity, and alignment to good practices based on the information provided at the World Bank workshops on Cash Flow Forecasting and Cash Management held in 2018 and 2019. The paper also draws on experiences and practices from other emerging and advanced countries. Cases from different countries indicate that full implementation of modern cash management is still a challenge, even though the Treasury Single Account system is
common in most countries and liquidity buffers were established or increased following the Global Financial Crisis. Cash flow forecasting is an area to improve given the accuracy, horizon and frequency of the projections are frequently limited. Fragmented institutional structure makes cash management even more challenging. Country cases also demonstrate that there is a significant room to strengthen coordination between debt and cash management and the use of short-term instruments to cover cash shortages. Investment of cash balances seems to be a bigger weakness as many countries keep their liquidity buffers in the Central Bank with no remuneration.
U.S. Individual Income Tax Return Simulated Data: A Methodology
Authors: Pelaez Alexander , Sledgianowski Deb , Petra Steven T. , Zhu Jianbing , Nejati Nooshin 
Published: June 2021

ABSTRACT
This paper proposes and tests a methodology for the development of simulated data for individual income tax returns in the U.S., enabling students of taxation and accounting, and other interested parties, to examine changes to the tax code, the effects of tax planning alternatives, and conduct repeated experimental testing on tax return data. The simulation draws insight from statistical and economic literature into the stochastic nature of certain line items from the tax returns, using the information provided by the Internal Revenue Service's (IRS) Statistics of Income (SOI) program. The simulation produced data for 147,000 tax returns, representing ∼1 percent of the population of filed tax returns, and was then validated against the results of the summary data provided by IRS SOI. Our simulated data closely matched the number and combined dollar value of the IRS SOI summary data at the AGI, state, and filing status levels.
Organized Crime and Firms' Financial Statements: Evidence from Criminal Investigations in Italy
Authors: Bianchi Pietro A. , Marra Antonio , Masciandaro Donato , Pecchiari Nicola 
Published: June 2021

ABSTRACT
We investigate how connections to organized crime manifest on firms' financial statements and analyze the impact of these connections on firm performance outcomes. Using a unique dataset that identifies Italian firms connected to organized crime, we find that connected firms have lower profitability, even though they report higher sales and lower labor cost. Connected firms also have higher bank debt, report lower cash holdings, experience quicker operating cycles and are more likely to file for bankruptcy. Further, we find that connected firms are more tax aggressive and engage in downward earnings manipulation. To corroborate our results, we exploit an amendment to the Italian Anti-Money Laundering regulation as a shock to the extent to which criminal organizations could expropriate connected firms' resources through money laundering. Our collective evidence suggests that connections to organized crime can drain a firm's resources, possibly through money-laundering schemes, and jeopardize its existence, thereby harming its shareholders.
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: G31; G32; G38; K42; K49.
Eye Outcomes in Veteran Affairs Diabetes Trial (VADT) After 17 Years
Authors: Azad Nasrin , Agrawal Lily , Bahn Gideon , Emanuele Nicholas V. , Reaven Peter D. , Hayward Rodney , Reda Domenic 
Published: June 2021

OBJECTIVE
The objective of this study was to assess the long-term role of intensive glycemic control (INT) compared with standard glycemic control in accumulated eye procedures in patients with advanced diabetes.

RESEARCH DESIGN AND METHODS
We compared the effect of treatment assignment on the accumulated number of eye procedures during the intervention period of the Veteran Affairs Diabetes Trial (VADT) (2000–2008) (median follow-up 5.6 years), the interim VADT follow-up study (2000–2013), and the full 17 years of VADT follow-up (2000–2017). We further analyzed data using various cardiovascular markers in two models. Model I included total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, systolic and diastolic blood pressure, and BMI. Model II included these covariates plus age and diabetic retinopathy (DR) severity score at baseline of the original trial.

RESULTS
The final analysis of the data showed a mild but nonsignificant increase in number of procedures and in retinal or retinal plus cataract surgery during the three periods of the study.

CONCLUSIONS
We found no significant benefit of INT during the original trial period in eye-related procedures, such as various procedures for DR, or during the 17 years of follow-up in cataract surgery. However, after adjusting data for some known vascular markers, the increase in the number of eye procedures with INT becomes more prevalent. This finding indicates that INT might not have a protective role in events requiring surgery in individuals with advanced diabetes.
Impact of Admission Hyperglycemia on Heart Failure Events and Mortality in Patients With Takotsubo Syndrome at Long-term Follow-up: Data From HIGH-GLUCOTAKO Investigators
Authors: Paolisso Pasquale , Bergamaschi Luca , Rambaldi Pietro , Gatta Gianluca , Foà Alberto , Angeli Francesco , Fabrizio Michele , Casella Gianni , Barbieri Michelangela , Galiè Nazzareno , Marfella Raffaele , Pizzi Carmine , Sardu Celestino 
Published: June 2021

OBJECTIVE
To investigate admission hyperglycemia effects on the sympathetic system and long-term prognosis in Takotsubo syndrome (TTS).

RESEARCH DESIGN AND METHODS
In patients with TTS and hyperglycemia (n = 28) versus normoglycemia (n = 48), serum norepinephrine and 123I-labeled metaiodobenzylguanidine (MIBG) cardiac scintigraphy were assessed. Heart failure (HF) occurrence and death events over 2 years were evaluated.

RESULTS
At hospitalization, those with hyperglycemia versus normoglycemia had higher levels of inflammatory markers and B-type natriuretic peptide and lower left ventricular ejection fraction. Glucose values correlated with norepinephrine levels (R2 = 0.39; P = 0.001). In 30 patients with TTS, 123I-MIBG cardiac scintigraphy showed lower late heart-to-mediastinum ratio values in the acute phase (P &lt; 0.001) and at follow-up (P &lt; 0.001) in those with hyperglycemia. Patients with hyperglycemia had higher rates of HF (P &lt; 0.001) and death events (P &lt; 0.05) after 24 months. In multivariate Cox regression analysis, hyperglycemia (P = 0.008), tumor necrosis factor-α (P = 0.001), and norepinephrine (P = 0.035) were independent predictors of HF events.

CONCLUSIONS
Patients with TTS and hyperglycemia exhibit sympathetic overactivity with a hyperglycemia-mediated proinflammatory pathway, which could cause worse prognosis during follow-up.
ANTESEDEN INTENSI ENTREPRENEURIAL DIGITAL PADA MAHASISWA UNIVERSITAS PADJADJARAN PADA MASA COVID-19
Authors: Suwandi Imam , Raharja Sam'un Jaja , Purnomo Margo 
Published: June 2021

The purpose of this article is to find out how knowledge acquisition and entrepreneurial opportunity recognition can be antecedents of digital entrepreneurial intentions in students of the Faculty of Social and Political Sciences, Universitas Padjadjaran Class of 2019 and 2020. Sampling used a simple random sample with a total of 96 samples. The data analysis tool uses the Structural Equation Model. The results showed that knowledge acquisition and entrepreneurial opportunity recognition had a significant effect on digital entrepreneurial intentions. Likewise, knowledge acquisition has a significant effect on entrepreneurial opportunity recognition. The effect of knowledge acquisition mediated by entrepreneurial opportunity recognition on digital entrepreneurial intentions has a smaller significance than the direct effect of knowledge acquisition on digital entrepreneurial intentions. This study adds a digital context in the field of entrepreneurial intention so that it makes a new contribution to entrepreneurship research. This study provides recommendations for further studies, especially discussions of digital entrepreneurial intentions, which involve a larger population reach. Tujuan dari artikel ini adalah untuk mengetahui bagaimana akuisisi pengetahuan dan pengenalan peluang entrepreneur dapat menjadi antesenden dari intensi entrepreneurial digital pada mahasiswa Fakultas Ilmu Sosial dan Ilmu Politik Universitas Padjadjaran Angkatan 2019 dan 2020. Sampling menggunakan simple random sampling dengan jumlah sebanyak 96 sampel.Alat analisis data memakai Structural Equation Model. Hasil penelitian memperlihatkan bahwa akuisisi pengetahuan dan pengenalan peluang entrepreneurial berpengaruh signifikan terhadap intensi entrepreneurial digital. Begitupun dengan akuisisi pengetahuan berpengaruh signifikan terhadap pengenalan peluang entrepreneurial. Penelitian ini menambahkan konteks digital dalam bidang entrepreneurial intention sehingga menambahkan kontribusi yang baru bagi penelitian entrepreneurship. Penelitian ini memberikan rekomendasi perlunya penelitianlebih lanjut khususnya pembahasan mengenai intensi entrepreneurial digital, yang melibatkan jangkauan populasi yang lebih besar.