bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tracking Blood Pressure Control Performance and Process Metrics in 25 US Health Systems: The PCORnet Blood Pressure Control Laboratory
Authors: Cooper‐DeHoff Rhonda M. , Fontil Valy , Carton Thomas , Chamberlain Alanna M. , Todd Jonathan , O’Brien Emily C. , Shaw Kathryn M. , Smith Myra , Choi Sujung , Nilles Ester K. , Ford Daniel , Tecson Kristen M. , Dennar Princess E. , Ahmad Faraz , Wu Shenghui , McClay James C. , Azar Kristen , Singh Rajbir , Faulkner Modrow Madelaine , Shay Christina M. , Rakotz Michael , Wozniak Gregory , Pletcher Mark J. 
Published: October 2021

Background
The National Patient‐Centered Clinical Research Network Blood Pressure Control Laboratory Surveillance System was established to identify opportunities for blood pressure (BP) control improvement and to provide a mechanism for tracking improvement longitudinally.

Methods and Results
We conducted a serial cross‐sectional study with queries against standardized electronic health record data in the National Patient‐Centered Clinical Research Network (PCORnet) common data model returned by 25 participating US health systems. Queries produced BP control metrics for adults with well‐documented hypertension and a recent encounter at the health system for a series of 1‐year measurement periods for each quarter of available data from January 2017 to March 2020. Aggregate weighted results are presented overall and by race and ethnicity. The most recent measurement period includes data from 1 737 995 patients, and 11 956 509 patient‐years were included in the trend analysis. Overall, 15% were Black, 52% women, and 28% had diabetes. BP control (<140/90 mm Hg) was observed in 62% (range, 44%–74%) but varied by race and ethnicity, with the lowest BP control among Black patients at 57% (odds ratio, 0.79; 95% CI, 0.66–0.94). A new class of antihypertensive medication (medication intensification) was prescribed in just 12% (range, 0.6%–25%) of patient visits where BP was uncontrolled. However, when medication intensification occurred, there was a large decrease in systolic BP (≈15 mm Hg; range, 5–18 mm Hg).

Conclusions
Major opportunities exist for improving BP control and reducing disparities, especially through consistent medication intensification when BP is uncontrolled. These data demonstrate substantial room for improvement and opportunities to close health equity gaps.
Circulating miR‐19b‐3p as a Novel Prognostic Biomarker for Acute Heart Failure
Authors: Su Yang , Sun Yuxi , Tang Yansong , Li Hao , Wang Xiaoyu , Pan Xin , Liu Weijing , Zhang Xianling , Zhang Fenglei , Xu Yawei , Yan Chunxi , Ong Sang‐Bing , Xu Dachun 
Published: October 2021

Background
Circulating microRNAs are emerging biomarkers for heart failure (HF). Our study aimed to assess the prognostic value of microRNA signature that is differentially expressed in patients with acute HF.

Methods and Results

Our study comprised a screening cohort of 15 patients with AHF and 5 controls, a PCR‐discovery cohort of 50 patients with AHF and 26 controls and a validation cohort of 564 patients with AHF from registered study DRAGON‐HF (Diagnostic, Risk Stratification and Prognostic Value of Novel Biomarkers in Patients With Heart Failure). Through screening by RNA‐sequencing and verification by reverse‐transcription quantitative polymerase chain reaction, 9 differentially expressed microRNAs were verified (miR‐939‐5p, miR‐1908‐5p, miR‐7706, miR‐101‐3p, miR‐144‐3p, miR‐4732‐3p, miR‐3615, miR‐484 and miR‐19b‐3p). Among them, miR‐19b‐3p was identified as the microRNA signature with the highest fold‐change of 8.4 and the strongest prognostic potential (area under curve with 95% CI, 0.791, 0.654–0.927). To further validate its prognostic value, in the validation cohort, the baseline level of miR‐19b‐3p was measured. During a follow‐up period of 19.1 (17.7, 20.7) months, primary end point comprising of all‐cause mortality or readmission due to HF occurred in 48.9% patients, while patients in the highest quartile of miR‐19b‐3p level presented the worst survival (Log‐rank
P
<0.001). Multivariate Cox model showed that the level of miR‐19b‐3p could independently predict the occurrence of primary end point (adjusted hazard ratio,1.39; 95% CI, 1.18–1.64). In addition, miR‐19b‐3p positively correlated with soluble suppression of tumorigenicity 2 and echocardiographic indexes of left ventricular hypertrophy.

Conclusions
Circulating miR‐19b‐3p could be a valuable prognostic biomarker for AHF. In addition, a high level of circulating miR‐19b‐3p might indicate ventricular hypertrophy in AHF subjects.

Registration

URL:
https://www.clinicaltrials.gov
. Unique Identifier: NCT03727828.
Impact of biochar amendment on soil nematode communities in a West African rain-fed rice cropland
Authors: Oladele Segun O. , Adeyemo Adebayo , Awodun Moses , Adegaye Ajoke , Ingold Mariko 
Published: October 2021

Summary
Nematode population and diversity in a West African rain-fed rice cropland amended with biochar (B), biochar plus inorganic fertiliser (B + NPK), inorganic fertiliser (NPK) and control (CK) without amendments were investigated in a 3-year field study. Results demonstrated that significant differences exist between treatments and years of study for total nematode population and nematode trophic groups. Total nematode density, nematode trophic group (bacterivore and plant-parasitic) density were increased and dominant in B + NPK compared with CK after 3 years. Relative abundance of nematode genera according to trophic group across treatments showed Hirschmanniella (23%) as the dominant plant parasites in NPK, and Heterocephalobus (27%), Aphelenchoides (22%) and Eudorylaimus (9%) as dominant bacterivores, fungivores and omnivores-predators, respectively, in B + NPK. Trophic group indicators showed that the fungivore plus bacterivore to plant-parasitic ratio (73%) was significantly increased by B + NPK treatment in comparison to CK. Conversely, treatments exerted no significant effect on the fungivore to bacterivore ratio (F/B) throughout the period of study, which implies less disturbance and adverse impact of biochar on nematode communities. Apart from treatments and environmental factors, changes in nematode trophic groups were strongly related to soil chemical properties, such as soil pH, total nitrogen and available phosphorus, which shows their influence on soil nematode community. Our result shows the positive effect of integrated addition of biochar and inorganic fertiliser in balancing nematode diversity and building a resilient soil ecosystem in a low input rain-fed rice cropping system.
Two new insect-associated tylenchids, Sychnotylenchus hibisci n. sp. and Neoditylenchus xiphydriae n. sp. (Tylenchomorpha: Anguinidae), from Japan
Authors: Kanzaki Natsumi , Kajimura Hisashi , Masuya Hayato , Akiba Mitsuteru , Ekino Taisuke , Tsujimoto Satoshi , Kosaka Hajime 
Published: October 2021

Summary
We isolated two tylenchid species belonging to the Sychnotylenchinae, Sychnotylenchus hibisci n. sp. and Neoditylenchus xiphydriae n. sp., from the bark beetle Ernoporus corpulentus and wood wasp Xiphydria ogasawarai, respectively. Sychnotylenchus hibisci n. sp. is characterised by its moderately stout body in both male and female, gubernaculum to spicule length ratio of one-third or less, crustaformeria structure composed of four columns with six large, rounded cells, and a broad female tail with a rounded terminus. The new species is closely related to S. ulmi, with which it shares body shape and gubernaculum to spicule length ratio, but is distinguished by the female tail shape and several morphometric values. Neoditylenchus xiphydriae n. sp. is characterised by its oval to leaf-shaped male bursa, male tail tip reaching the distal end of, and protruding beyond the bursa, a long post-vulval uterine sac (PUS), and a conical female tail with a narrowly rounded terminus. The species is typologically similar to N. pinophilus but is distinguished by its male spicule shape, gubernaculum to spicule length ratio, and longer PUS. Phylogenetically, the Sychnotylenchinae belongs under the Anguinidae (superfamily Sphaerularioidea) and is closely related to several Ditylenchus, Neotylenchus, Neomisticius, and Ficotylus species.
Meloidogyne enterolobii development and reproduction in tomato plants treated with resistance inducers
Authors: Silva Juliana de O. , Oliveira Camilla M. , Carneiro Renê G. da S. , da Rocha Mara R. 
Published: October 2021

Summary
Meloidogyne enterolobii is a species capable of overcoming plant resistance moderated by the Mi-1 gene, which is effective against most species of root-knot nematode. This study evaluated the effect of induced resistance in tomato plants (Solanum lycopersicum ‘H-9553’) with the Mi-1 gene against the development and reproduction of M. enterolobii. Seedlings of tomato ‘H-9553’ were transplanted into pots, inoculated with 2000 eggs and second-stage juveniles (J2) of M. enterolobii and treated with Acibenzolar-S-Methyl, Bacillus subtilis, B. subtilis + B. licheniformis + Trichoderma longibrachiatum and extract of Reynoutria sachalinensis. The plants were collected at 5, 10, 15, 20, 25 and 30 days after inoculation (DAI) for the analyses of nematode penetration and development, and at 30 DAI for nematode reproduction. The use of B. subtilis increased fresh root weight when compared to the other treatments (20 DAI). There was a reduction in penetration of J2 in the roots of plants subjected to different resistance inducers. The population density of M. enterolobii was significantly reduced only when plants were treated with R. sachalinensis, indicating it as a potential resistance-inducing agent in tomato plants.
Development and Characterization of an Electrocochleography‐Guided Robotics‐Assisted Cochlear Implant Array Insertion System
Authors: Henslee Allan M. , Kaufmann Christopher R. , Andrick Matt D. , Reineke Parker T. , Tejani Viral D. , Hansen Marlan R. 
Published: October 2021

ObjectiveElectrocochleography (ECochG) is increasingly being used during cochlear implant (CI) surgery to detect and mitigate insertion‐related intracochlear trauma, where a drop in ECochG signal has been shown to correlate with a decline in hearing outcomes. In this study, an ECochG‐guided robotics‐assisted CI insertion system was developed and characterized that provides controlled and consistent electrode array insertions while monitoring and adapting to real‐time ECochG signals.Study DesignExperimental research.SettingA research laboratory and animal testing facility.MethodsA proof‐of‐concept benchtop study evaluated the ability of the system to detect simulated ECochG signal changes and robotically adapt the insertion. Additionally, the ECochG‐guided insertion system was evaluated in a pilot in vivo sheep study to characterize the signal‐to‐noise ratio and amplitude of ECochG recordings during robotics‐assisted insertions. The system comprises an electrode array insertion drive unit, an extracochlear recording electrode module, and a control console that interfaces with both components and the surgeon.ResultsThe system exhibited a microvolt signal resolution and a response time <100 milliseconds after signal change detection, indicating that the system can detect changes and respond faster than a human. Additionally, animal results demonstrated that the system was capable of recording ECochG signals with a high signal‐to‐noise ratio and sufficient amplitude.ConclusionAn ECochG‐guided robotics‐assisted CI insertion system can detect real‐time drops in ECochG signals during electrode array insertions and immediately alter the insertion motion. The system may provide a surgeon the means to monitor and reduce CI insertion–related trauma beyond manual insertion techniques for improved CI hearing outcomes.
Patterns of Failure After Definitive Treatment of T4a Larynx Cancer
Authors: Voora Rohith S. , Panuganti Bharat A. , Flagg Mitchell , Nelson Tyler , Kotha Nikhil V. , Qiao Edmund M. , Qian Alexander S. , Kumar Abhishek , Stewart Tyler F. , Rose Brent , Califano Joseph , Weissbrod Philip A. , Mell Loren K. , Orosco Ryan K. 
Published: October 2021

ObjectiveRecurrence is known to predict laryngeal squamous cell cancer (LSCC) survival. Recurrence patterns in T4a LSCC are poorly characterized and represent a possible explanation for observed survival discrepancies by treatment rendered.Study DesignRetrospective database review.SettingVeterans Affairs national database.MethodsPatients with T4a LSCC between 2000 and 2017 were identified and stratified by treatment (chemoradiotherapy [CRT] vs total laryngectomy + neck dissection + adjuvant therapy [surgical]). Primary outcomes were locoregional and distant recurrence. Secondary outcomes of overall mortality, larynx cancer mortality, and noncancer mortality were evaluated in Cox and Fine‐Gray models.ResultsA total of 1043 patients had comparable baseline demographics: 438 in the CRT group and 605 in the surgical group. Patients undergoing CRT had higher proportions of node positivity (64.6% vs 53.1%, P <. 001). Locoregional and distant recurrence were less common in the surgical group (23.0% vs 37.2%, P <. 001; 6.8% vs 13.3%, P <. 001, respectively); however, distant metastatic rates did not differ within the N0 subgroup (P =. 722). On multivariable regression, surgery demonstrated favorable locoregional recurrence (hazard ratio [HR], 0.49; 95% CI, 0.39‐0.62; P <. 001), distant recurrence (HR, 0.47; 95% CI, 0.31‐0.71; P <. 001), overall mortality (HR, 0.75; 95% CI, 0.64‐0.87; P <. 001), and larynx cancer mortality (HR, 0.69; 95% CI, 0.56‐0.85; P <. 001).ConclusionT4a LSCC survival discrepancies between surgical and nonsurgical treatment are influenced by varying recurrence behaviors. Surgery was associated with superior disease control and improved survival. Beyond the known benefit in locoregional control with surgery, there may be a protective effect on distant recurrence that depends on regional disease burden.
Public Health Perspectives of Geriatric Mental Health Care
Authors: Rangarajan Subhashini K. , Sivakumar Palanimuthu Thangaraju , Manjunatha Narayana , Kumar Channaveerachari Naveen , Math Suresh Bada 
Published: October 2021

Background: In older adults (aged 60 years and above), mental health problems are gaining public health importance because of the increasing prevalence, disease burden, disability, morbidity, and mortality. Epidemiological studies on major mental health disorders such as depression and dementia in older adults have contributed to a better understanding of the distribution and determinants of these conditions. Identifying potential risk factors has stimulated interventional research on preventing these conditions under the public health framework towards their management. The increasing burden of geriatric mental health conditions like dementia in developing countries like India can contribute to significant challenges if there is no adequate strengthening of the public health response. This includes scaling up the measures of prevention, public awareness, early diagnosis, and quality health and social care equitably available to all sections of the population. The Decade of Healthy Ageing (2021–2030) provides the opportunity for concerted and coordinated initiatives to improve intrinsic capacity (physical and mental) and offer an age-friendly environment to enhance the functional ability of all older adults. Methods: This article reviews the critical public health issues related to geriatric mental health in India.
Scutellarin alleviates type 2 diabetes (HFD/low dose STZ)-induced cardiac injury through modulation of oxidative stress, inflammation, apoptosis and fibrosis in mice
Authors: Huo Yan , Mijiti Abudureheman , Cai Ruonan , Gao Zhaohua , Aini Maierpu , Mijiti Abudukadier , Wang Zhaoling , Qie Rui 
Published: October 2021

Background Diabetes is a serious global health concern which severely affected public health as well as socio-economic growth worldwide. Scutellarin (SCU), a bioactive flavonoid, is known for its efficacious action against a range of ailments including cardiovascular problems. The present study was conducted to find out possible protective effect and its associated mechanisms of SCU on experimental type 2 diabetes-induced cardiac injury. Methods Type 2 diabetes was induced by treating animals with high fat diet for 4 weeks and a single intraperitoneal dose (35 mg/kg body weight) of streptozotocin and diabetic animals received SCU (10 or 20 mg/kg/day) for 6 weeks. Results Scutellarin attenuated type 2 diabetes-induced hyperglycemia, bodyweight loss, hyperlipidaemia, cardiac functional damage with histopathological alterations and fibrosis. Scutellarin treatment to type 2 diabetic mice ameliorated oxidative stress, inflammatory status and apoptosis in heart. Furthermore, the underlying mechanisms for such mitigation of oxidative stress, inflammation and apoptosis in heart involved modulation of Nrf2/Keap1 pathway, TLR4/MyD88/NF-κB mediated inflammatory pathway and intrinsic (mitochondrial) apoptosis pathway, respectively. Conclusions The current findings suggest that SCU is effective in protecting type 2 diabetes-induced cardiac injury by attenuating oxidative stress and inflammatory responses and apoptosis, and it is also worth considering the efficacious potential of SCU to treat diabetic cardiomyopathy patients.
Platformizing family production: The contradictions of rural digital labor in China
Authors: Zhang Lin 
Published: October 2021

AbstractHow is the rise of platform capitalism reinventing the traditional regime of familial production, while at the same time being energized by it? How do the historically informed, lived experiences of rural e-commerce entrepreneurs or workers in China help reconceptualize digital labor and platform studies? Deploying the analytic of platformized family production, this article addresses these questions through a deep description of the experiences of variously positioned platform-based and mediated laborers in an e-commerce village in East China. I argue that the ongoing process of platformizing family production is profoundly contradictory. As an alternative to a model of development based on unevenness and the rural-urban divide, village e-commerce has created opportunities for peasants and marginalized urban youth to achieve social mobility. However, it also shapes a new regime of value that privileges the individualized e-commerce entrepreneur as an ideal subject, and fetishizes and instrumentalizes innovation and creativity in conformity with the global intellectual property regime. These tendencies not only contradict the reality of collective labor organization both on e-commerce platforms and in villages, but also conflict with the indispensable role of manual labor in the production process—reinforcing rather than overcoming existing inequalities and stratification in rural China.
Third-Generation Minimally Invasive Chevron-Akin Osteotomy for Hallux Valgus Produces Similar Clinical and Radiological Outcomes as Scarf-Akin Osteotomy at 2 Years: A Matched Cohort Study
Authors: Tay Adriel You Wei , Goh Graham S. , Koo Kevin , Yeo Nicholas Eng Meng 
Published: October 2021

Background: The minimally invasive chevron-Akin (MICA) osteotomy is an increasingly popular technique for the correction of hallux valgus. However, there is a paucity of literature comparing it with traditional open techniques. The purpose of this study was to compare the clinical and radiological outcomes of the MICA osteotomy using a new-generation MICA screw and scarf-Akin osteotomy for hallux valgus correction. Methods: Thirty cases of MICA osteotomy were propensity score matched 1:1 with a control group of 30 scarf-Akin osteotomy cases. The groups were matched for age, sex, body mass index, preoperative visual analog scale (VAS) score, American Orthopaedic Foot & Ankle Society (AOFAS) metatarsophalangeal-interphalangeal (MTP-IP) score, 36-Item Short-Form Health Survey (SF-36) physical component score (PCS) and mental component score (MCS), preoperative hallux valgus angle (HVA) and intermetatarsal angle (IMA), and concomitant procedures. Outcomes were compared at 6 and 24 months postoperatively. Early postoperative VAS scores were also compared. Results: Both groups demonstrated significant improvements in VAS score, AOFAS score, and SF-36 PCS and MCS at 6 and 24 months postoperatively. For the MICA group, HVA improved from 23.5 to 7.7 degrees, and IMA improved from 13.5 to 7.5 degrees. For the scarf-Akin osteotomy group, HVA improved from 23.7 to 9.3 degrees, and IMA improved from 13.6 to 7.8 degrees. The first 24-hour postoperative VAS score was significantly lower in the MICA group compared with the scarf-Akin group (2.0 ± 2.0 vs 3.4 ± 2.6, P = .029). However, there was no significant difference in clinical or radiological outcomes between the groups at 6 and 24 months. Conclusion: The MICA procedure with the new-generation MICA screw is an attractive option for the correction of hallux valgus, yielding similar midterm radiological and clinical outcomes compared with the well-established scarf-Akin osteotomy. The first 24-hour postoperative VAS score in the MICA group was also statistically lower, although its clinical significance remains to be determined. Level of Evidence: Level III, retrospective comparative study.
Use of nab-paclitaxel and gemcitabine in pancreatic cancer without granulocyte colony-stimulating factor: A multicenter real-world experience
Authors: Chen Angela , Ha Vincent H , Ghosh Sunita , Chambers Carole R , Sawyer Michael B 
Published: October 2021

Introduction The metastatic pancreatic adenocarcinoma clinical trial (MPACT) trial established gemcitabine (gem) and nab-paclitaxel (nab) as a standard treatment for pancreatic cancer utilizing granulocyte colony-stimulating factors to manage neutropenia. This was a challenge for jurisdictions that do not use granulocyte colony-stimulating factors in palliative settings. We developed dosage guidelines to dose modify gem and nab without granulocyte colony-stimulating factors. We undertook a retrospective review to determine the efficacy and safety of these dose adjustment guidelines in the real world. Methods A multi-centered, retrospective chart review was performed on pancreatic patients between December 1, 2014, and August 21, 2018. Provincial electronic medical health records were reviewed. Using Log-rank statistics we determined the patient's progression-free survival and overall survival. Results Of 248 patients, 209 met patient selection criteria. Patients were excluded if they were lost to follow-up, on gem alone prior to nab/gem combination therapy or did not receive nab or gem. Patients who received nab/gem as first-line therapy had a median progression-free survival of 6.3 months (95% CI, 5.1–7.4), and median overall survival of 11.1 months (95% CI, 9.5–12.8). Those who received gem/nab in the second line had a median progression-free survival of 4.6 months (95% CI, 2.8–6.5), and median overall survival of 19.3 months (95% CI, 12.6–26.0). Conclusions The patient’s progression-free survival and overall survival taking nab/gem using our dose modification algorithm were equivalent or superior to the MPACT trial's progression-free survival and overall survival. Gem/nab can be given by our dose modification scheme without granulocyte colony-stimulating factor.