bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Production Life of Wheatstone Project Offshore Australia Yields Key Lessons
Authors: Carpenter Chris 
Published: September 2021

This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 202246, “Wheatstone: What We Have Learned in Early Production Life,” by John Pescod, SPE, Paul Connell, SPE, and Zhi Xia, Chevron, et al., prepared for the 2020 SPE Asia Pacific Oil and Gas Conference and Exhibition, originally scheduled to be held in Perth, Australia, 20–22 October. The paper has not been peer reviewed.
Wheatstone and Iago gas fields, part of the larger Wheatstone project, commenced production in June 2017. The foundation subsea system includes nine Wheatstone and Iago development wells tied back to a central Wheatstone platform (WP) for processing. Hydrocarbons then flow through an export pipeline to an onshore processing facility that includes two liquefied-natural-gas (LNG) trains and a domestic gas facility. The complete paper highlights some of the key learnings in well and reservoir surveillance analysis and optimization (SA&O) developed using data from early production.

Asset Overview
Chevron Australia’s Wheatstone project is in the North West Shelf region offshore Australia (Fig. 1). Two gas fields, Wheatstone and Iago (along with a field operated by a different company), currently tie into the WP in the Northern Carnarvon Basin. These two gas fields are in water depths between 150 and 400 m. The platform processes gas and condensate through dehydration and compression facilities before export by a 220-km, 44-in., trunkline to two 4.45-million-tonnes/year LNG trains and a 200 tera-joule/day domestic gas plant.
A Wheatstone/Iago subsea system consisting of two main corridors delivers production from north and south of the Wheatstone and Iago fields to the WP. Currently, the subsea system consists of nine subsea foundation development wells, three subsea production manifolds, two subsea 24-in. production flowlines, and two subsea 14-in. utility lines.
The nine foundation development wells feed the subsea manifolds at rates of up to 250 MMscf/D. These wells have openhole gravel-pack completions for active sand control and permanent downhole gauges situated approximately 1000-m true vertical depth above the top porosity of multi-Darcy reservoir intervals for pressure and temperature monitoring. All wells deviate between 45 and 60° through the reservoir with stepout lengths of up to 2.5 km.
The two subsea 24-in. production flowlines carry production fluids from the subsea manifolds to two separation trains on the WP. Each platform inlet production separator can handle up to 800 MMscf/D. The two 14-in. utility flowlines installed to the subsea manifolds allow routing of a single well to the platform multiuse header, which can direct flow into the multiuse separator (MUS) or other production separators at a rate of 250 MMscf/D.
Technology Helps Combat Driver Fatigue: Case Study From the Middle East
Authors: Carpenter Chris 
Published: September 2021

This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 203350, “How Technology Can Support Tackling Drivers’ Fatigue: Case From Petroleum Development Oman,” by Demir Hadzic and Hamed Al Esry, Petroleum Development Oman, and David Marsh, Sheida International, prepared for the 2020 Abu Dhabi International Petroleum Exhibition and Conference, Abu Dhabi, held virtually 9–12 November. The paper has not been peer reviewed.
Petroleum Development Oman operates in harsh environments over which their drivers cover more than 320 million km annually. Driver fatigue is one of the leading causes of motor vehicle incidents (MVIs) associated with operations. The objective of the complete paper is to understand further how technology can support the prevention of driver fatigue and to explore driver beliefs related to fatigue and the technology designed to assist in fatigue avoidance. This study helped the operator’s safety specialists understand driver fatigue and develop mechanisms to prevent it.

Introduction
Previous research has found that motor vehicle crash fatalities in the oil and gas industry are up to 8.5 times more com-mon than in other occupations. A qualitative study by the operator indicated that participants commonly perceived fatigue as a main factor in MVIs. However, understanding of the nature and role of fatigue in MVIs was revealed to be relatively limited. Among the driver group interviewed, a common view existed that the responsibility for managing driver fatigue lay with the employer and not with drivers. In addition, among the driver group, there appeared to be little understanding of the effects that lifestyle outside of work has on driver fatigue. The pilot study showed that driver fatigue occurred once every three journeys on average, whereas driver distractions could occur more than four times in a single journey.

Equipment and Processes
Technology used in the study consists of in-cabin hardware units, analytical software integration with in-vehicle monitoring systems (IVMS), and participation of a monitoring team. In addition, event verification is performed by human monitors and feedback. Driver fatigue is part of a comprehensive integrated journey-management system developed by the operator, including standard operating procedures with regard to monitoring and event classification, verification, and response.
Abrupt Temperature Change In Winter Over The Mongolian Plateau For The Past 60 Years
Authors: Xia Yingying , Chun Xi , Dan Dan , Zhou Haijun , Wan Zhiqiang 
Published: September 2021

Abstract
Studying the abrupt temperature change in winter over the Mongolian Plateau (MP) is of great significance for understanding the spatiotemporal distribution of temperature and the mechanism of global climate change. Monthly temperature data of MP were collected during 1961–2017, the abrupt-change point was determined by the Mann–Kendall test and sliding t-test to analyze the characteristics and causes of abrupt temperature change in winter. The results showed that (a) The increase rate of winter temperature was 0.41 ℃/10a, with a contribution rate of 30.7 % to annual temperature change, which was significantly higher than that of mainland China, indicating that climate change in the MP was more sensitive to global warming. (b) The abrupt-change point occurred in 1988, with temperatures of -15.5 ℃ and − 14.1°C before and after 1988, respectively, the increasing range was 9%. The abrupt temperature change in high latitudes was 1–3 years later than that in low latitudes. (c) The isotherms of different temperatures in winter moved northward by 10–200 km, especially − 16°C isotherm moved approximately 200 km northward after 1988, thereby the MP warmed significantly. (d) there was a good coupling relationship between the Arctic Oscillation (AO) and winter temperature. AO affects temperature change by influencing the Mongolia–Siberian High, therefore, it may be an important factor to drive the abrupt temperature change in winter.
Computational Investigation of Adenosine 5′- (α, β-methylene)- diphosphate (AMPCP) Derivatives as Ecto-5′-nucleotidase (CD73) Inhibitors by Using 3D-QSAR, Molecular Docking, and Molecular Dynamics Simulations
Authors: Wen Jiatong , Zhang Heng , Meng Churen , Zhou Di , Chen Gang , Wang Jian , Liu Yang , Yuan Lei , Li Ning 
Published: September 2021

Abstract
CD73, as a surface enzyme anchored on the outside of the cell membrane via glycosylphosphatidylinositol (GPI), can convert the AMP in the tumor cell microenvironment into adenosine to promote the growth of tumor cells. It has been overexpressed in many different types of human tumors, such as gastric cancer, pancreatic cancer, liver cancer and other tumor cells. Therefore, targeted inhibitors of CD73 are considered as potential tumor treatment methods. Due to the low bioavailability of nucleoside CD73 inhibitors, it is necessary to develop new inhibitors. In this study, through molecular docking, three-dimensional quantitative structure-activity relationship (3D-QSAR) and molecular dynamics (MD) simulations, a series of CD73 inhibitors were calculated and studied to reveal their structure-activity relationships. Through molecular docking studies, explore the possible mode of interaction between inhibitors and protein. Subsequently, a 3D-QSAR model was established by comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA). For the best CoMFA model, the Q2 and R2 values ​​are 0.708 and 0.983, respectively, while for the best CoMSIA model, the Q2 and R2 values ​​are 0.809 and 0.992, respectively. In addition, the stability of the complex formed by the two inhibitors and CD73 was evaluated by molecular dynamics simulation, and the results are consistent with the results of molecular docking and 3D-QSAR research. Finally, the binding free energy was calculated by the surface area method (MM-GBSA), and the results are consistent with the activities that Van Der Waals and Coulomb contribute the most during the binding process of the molecule to the CD73 protein. In conclusion, our research provides valuable information for the further development of CD73 inhibitors.
Impaired type I interferon signaling activity implicated in the peripheral blood transcriptome of preclinical Alzheimer’s disease
Authors: Song Liting , Chen Jingqi , Lo Chun-Yi , Guo Qihao , Feng Jianfeng , Zhao Xing-Ming 
Published: September 2021

Abstract
Subjective cognitive decline (SCD) is considered the preclinical manifestation of Alzheimer’s disease (AD), which is a potentially crucial window for preventing or delaying the progression of the disease. To explore the potential mechanism of disease progression and identify relevant biomarkers, we comprehensively assessed the peripheral blood transcriptomic alterations in SCD, covering lncRNA, mRNA, and miRNA. Dysregulated protein-coding mRNA at both gene and isoform levels implicated impairment in the type I interferon signaling pathway in SCD. Specifically, this pathway was regulated by the transcription factor STAT1 and ncRNAs NRIR and has-miR-146a-5. The miRNA-mRNA-lncRNA coexpression network revealed hub genes for the interferon module. Individuals with lower interferon signaling activity and lower expression of hub genes STAT1 and TRIM22 exhibited a higher conversion rate to mild cognitive impairment (MCI). Our findings illustrated the down-regulation of interferon signaling activity would potentially increase the risk of disease progression and thus serve as a pre-disease biomarker.
Synthesis and Characterization of Nano-SiO2@octadecylbisimidazoline Quaternary Ammonium Salt Using as Acidizing Corrosion Inhibitor
Authors: Liu Yunfeng , Zhang Xingde , Qiu Zhengsong , Chen Lili 
Published: September 2021

Abstract
Aiming at the current situation that the existing acidizing corrosion inhibitors are difficult to apply to high temperature, high concentration acid, and other complex conditions. This paper uses nano-SiO2 as the core and preferably functional monomers to synthesize nano-SiO2@octadecylbisimidazoline quaternary ammonium salt. Analytical methods such as nuclear magnetic resonance, infrared, SEM were used for characterization. The corrosion inhibition performance of the N80 steel sheet by nano-SiO2@octadecylbisimidazoline quaternary ammonium salt in 20% concentrated hydrochloric acid was studied using the high-temperature corrosion testing machine and adsorption isotherm model. Combined with quantum chemistry calculations to explore its mechanism of action. The results show that nano-SiO2@octadecylbisimidazoline quaternary ammonium salt has good high-temperature resistance. When the temperature is 180℃ and the dosage of nano-SiO2@octadecylbisimidazoline quaternary ammonium salt is 4%, the corrosion inhibition rate is 61.42g·m− 2·h− 1. Studies have shown that the adsorption of nano-SiO2@octadecylbisimidazoline quaternary ammonium salt on the surface of the N80 steel sheet follows the Langmuir isotherm adsorption model, which is spontaneous chemical adsorption.
Adsorption And Diffusion of The H2/CO2 /CO /MeOH /EtOH Mixture Into The ZIF-7 Using Molecular simulation
Authors: Keyvanloo Zahra , Pour Ali Nakhaei , Moosavi Fatemeh 
Published: September 2021

Abstract
The adsorption and diffusion of synthesis gas components (methanol, ethanol, H2, CO2, and CO molecules) in ZIF-7 by grand canonical Monte Carlo and molecular dynamics simulation were investigated. The initial diffusion coefficient at the beginning of the process depends on the kinetic diameter of the guest molecules. Also, the diffusion coefficient at equilibrium conditions probably depends on the interaction between the guest molecules with the ZIF-7 framework. The radial distribution function results indicate that the distribution of guest molecules in the framework is affected by the interaction between the guest molecules. These results also demonstrate that the Zn atom and the organic linker are favorable sites for CO2, CO, and H2. In contrast, the organic linker is the most favorable adsorption site for methanol and ethanol guest molecules. In addition, the diffusion coefficient of guest molecules in binary mixtures is related to the attraction or repulsion between the guest molecules.
Modeling Malaria Incidence Associated with Environmental Risk Factors in Ethiopia using the Geographically Weighted Regression Model, 2015-2016
Authors: Dadi Berhanu Berga 
Published: September 2021

Abstract
Background: In Ethiopia, still, malaria is killing and affecting a lot of people of any age group somewhere in the country at any time. However, due to limited research, little is known about the spatial patterns and correlated risk factors on the wards scale. Methods: In this research, we explored spatial patterns and evaluated related potential environmental risk factors in the distribution of malaria incidence in Ethiopia in 2015 and 2016. Hot Spot Analysis (Getis-Ord Gi* statistic) was used to assess the clustering patterns of the disease. The ordinary least square (OLS), geographically weighted regression (GWR), and semiparametric geographically weighted regression (s-GWR) models were compared to describe the spatial association of potential environmental risk factors with malaria incidence.Results: Our results revealed a heterogeneous and highly clustered distribution of malaria incidence in Ethiopia during the study period. The s-GWR model best explained the spatial correlation of potential risk factors with malaria incidence and was used to produce predictive maps. The GWR model revealed that the relationship between malaria incidence and elevation, temperature, precipitation, relative humidity, and normalized difference vegetation index (NDVI) varied significantly among the wards. During the study period, the s-GWR model provided a similar conclusion, except in the case of NDVI in 2015, and elevation and temperature in 2016, which were found to have a global relationship with malaria incidence. Hence, precipitation and relative humidity exhibited a varying relationship with malaria incidence among the wards in both years. Conclusions: This finding could be used in the formulation and execution of evidence-based malaria control and management program to allocate scare resources locally at the wards level. Moreover, these study results provide a scientific basis for malaria researchers in the country.
Low proteolytic processing of histone H3 in cervical tissue positive to hrHPV
Authors: Alcaraz-Estrada Sofia L. , Serafín-Higuera Nicolás , Ramos-Mondragón Roberto , Reyes-Hernández Octavio D. , Figueroa-González Gabriela , Daniel-García Oscar , Millán-Testa Claudia E. , Blanco-Morales Magali , SANDOVAL-BASILIO JORGE 
Published: September 2021

Abstract
During the different stages of cervical carcinogenesis there is an accumulation of epigenetic alterations leading to changes in gene expression. High-risk human papillomavirus (hrHPV) is a primary risk factor for cervical cancer (CC). Impaired proteolytic processing of histone H3 constitutes a potential epigenetic mechanism in CC. However, whether this event occurs in early stages of the HPV infection is unknown. Using human cervical samples with normal pathology but positive and negative to hrHPV, we identified that the H3 cleavage was low in the hrHPV positive cervix compared to the hrHPV negative cervix. These results suggest that low H3 processing previously observed in CC may be a primary effect of hrHPV infection.
Population-Level Laterality In Foraging Finless Porpoises
Authors: Amano Masao , Kawano Yudai , Kubo Taketo , Kuwahara Tsuyoshi , Kobayashi Hayao 
Published: September 2021

Abstract
Laterality has been reported in many vertebrates, and asymmetrical cerebral hemisphere function has been hypothesized to cause a left-bias in social behavior and a right-bias in feeding behavior. In this paper, we provide the first report of behavioral laterality in free-ranging finless porpoises, which seemingly supports the aforementioned hypothesis. We observed the turning behavior of finless porpoises in Omura Bay, Japan, using land-based and unmanned aerial system observations. We found a strong tendency in finless porpoises to turn counterclockwise with their right side down when pursuing and catching fish at the surface of the water. Our results suggest that this population of finless porpoises shows consistent right-biased laterality. Right-biased laterality has been observed in various foraging cetaceans and is usually explained by the dominance of the right eye-left cerebral hemisphere in prey recognition; however, right-biased laterality in foraging cetaceans may have multiple causes.
A Study On Machining Characteristics of Al7075-NiCr-Gr Metal Matrix Composites Through Wire – Cut Electro Discharge Machining
Authors: Palani R. , Sakthivel M. , Chithambaram V. , Palani Geetha 
Published: September 2021

Abstract
The aluminium and its alloys play a vital role in industry for their wide practical applications. In the present work, Al7075 was reinforced with Ni-Cr and graphite by Stir casting method. Further the optimization of the machined composite was done by Taguchi method. It was inferred that the MRR value of 0.056435 g/min was obtained with input parameters of 8 amps current, 52 Volt, 4 µs pulse on time, 17 µs pulse off time by machining with WEDM and SR value of 3.3 µm showing smooth surface. The material removal rate of the composite was found and the morphology of the material was analysed by SEM with associated elemental analysis by energy dispersive spectrometer (EDS). The reinforcements present in the composite were also verified. The outcome of this micro structural investigation revealed that a non-uniform distribution of graphite particles takes place at all weight percentages of graphite reinforcement.
Impact of COVID 19 Pandemic on the Quality of Life of Migrant Slum Dwellers of India: a Qualitative Study in Delhi State
Authors: ROY NIVEDITA 
Published: September 2021

Abstract
Background: During the COVID pandemic, migrant workers had experienced harsh livelihood and socio-economic crises which amplified their challenges of life and significantly affected their mental health. However, there is a lack of in-depth evidence on how the mental trauma and shock of the loss of job and livelihood crisis affected men and women migrant workers differently. This study aimed to explore the impact of the COVID pandemic and lockdown on migrant workers who had faced psycho-social and financial challenges during the pandemic and lockdown and the effects of these challenges on their health. Methods: A formative research method comprising of iterative approach was used by conducting in-depth interviews of men and women migrant workers residing in randomly selected 2 blocks of a slum called Madanpur Khadar JJ Colony of Delhi, India. The respondents were chosen using a respondent driven purposive sampling depending on those who had faced severe loss during the pandemic. The migrant workers were interviewed about their challenges until saturation point was reached. In total 25 men and 25 women migrant workers were interviewed. Results: The financial constraints due to loss of employment, closing down of small scale self employment ventures, salary cuts and loans, threw life out of gear, further marginalizing the already disadvantaged community, who live from hand to mouth. To further aggravate the damage, COVID brought with it social stigma, discrimination, fear, stress, and anxiety. Women migrant workers bore the brunt of the burden of household responsibilities, increased demand without support and emotional abuse at home. Conclusions: There is an urgent need for unified social protection system with preventive, promotion-stricken, protective, and transformational measures designed through a crisis-responsive lens is required to provide an ecosystem of support to migrant workers.
Sacubitril-valsartan in Heart Failure With Preserved Ejection Fraction Following Acute Coronary Syndrome
Authors: Han Zhi-hua , Wang Chang-qian , Zhang Jun-feng , Gu Jun 
Published: September 2021

Abstract
BackgroundIt was indicated that sacubitril-valsartan could improve the clinical prognosis in specific phenotype of heart failure with preserved ejection fraction (HFpEF) patients compared with valsartan. However, there is lack of evidence of the comparative effectiveness in HFpEF patients following acute coronary syndrome (ACS). The aim of this study was to evaluate whether the selection between sacubitril-valsartan and angiotensin-converting enzyme inhibitor (ACEI)/angiotensin II receptor blocker (ARB) in HFpEF after ACS confered a prognostic benefit. MethodsUsing a propensity score matching of 1:2 ratio, this retrospective claims database study compared sacubitril-valsartan prescription (n=85) and ACEI/ARB therapy (n=170) in patients with HFpEF following ACS. Cox regression analysis was performed to assess the association between treatment and composite endpoints (all-cause mortality or hospitalization for heart failure). ResultsWith a follow-up of 2 years, 52 patients (20.4%) either died from any cause or were hospitalized for heart failure, in which 10 patients (11.8%) with prescribed with sacubitril-valsartan and 42 patients (24.7%) treated with ACEI/ARB (P=0.016). Sacubitril-valsartan therapy was beneficial in N-terminal Pro-B-type natriuretic peptid (NT-proBNP) reduction as well as left ventricular ejection fraction (LVEF) change. And Cox proportional hazards regression model revealed that sacubitril-valsartan prescription (HR 0.473, 95% CI: 0.233-0.961, P=0.038) was associated with a reduced risk of the occurrence of composite endpoints.ConclusionLong-term sacubitril-valsartan exposure was associated with protective effects in terms of the incidence of cardiovascular events in patients with HFpEF following ACS.