bluuebunny/crossref_metadata_2025_split huggingface dataset:
CORALIE radial-velocity search for companions around evolved stars (CASCADES)
Authors: Pezzotti C. , Ottoni G. , Buldgen G. , Lyttle A. , Eggenberger P. , Udry S. , Ségransan D. , Mayor M. , Lovis C. , Marmier M. , Miglio A. , Elsworth Y. , Davies G. R. , Ball W. H. 
Published: April 2021

Context. Increasing the number of detected exoplanets is far from anecdotal, especially for long-period planets that require a long duration of observation. More detections imply a better understanding of the statistical properties of exoplanet populations, and detailed modelling of their host stars also enables thorough discussions of star–planet interactions and orbital evolution of planetary systems.
Aims. In the context of the discovery of a new planetary system, we aim to perform a complete study of HD 29399 and its companion by means of radial-velocity measurements, seismic characterisation of the host-star, and modelling of the orbital evolution of the system.
Methods. High-resolution spectra of HD 29399 were acquired with the CORALIE spectrograph mounted on the 1.2-m Swiss telescope located at La Silla Observatory (Chile) as part of the CASCADES survey. We used the moments of the cross-correlation function profile as well as the photometric variability of the star as diagnostics to distinguish between stellar and planetary-induced signals. To model the host star we combined forward modelling with global and local minimisation approaches and inversion techniques. We also studied the orbital history of the system under the effects of both dynamical and equilibrium tides.
Results. We present the detection of a long-period giant planet. Combining these measurements with photometric observations by TESS, we are able to thoroughly model the host star and study the orbital evolution of the system. We derive stellar and planetary masses of 1.17 ± 0.10 M⊙ and 1.59 ± 0.08 MJup, respectively, and an age for the system of 6.2 Gyr. We show that neither dynamical nor equilibrium tides have been able to affect the orbital evolution of the planet. Moreover, no engulfment is predicted for the future evolution of the system.
Vorsorgeuntersuchungen und Routineimpfungen bei Vorschulkindern – Eine Analyse zum wechselseitigen Teilnahmeverhalten unter Einbeziehung der Lebensverhältnisse
Authors: Stich Heribert 
Published: April 2021

Zusammenfassung
Ziel der Studie U-Vorsorgeuntersuchungen und Impfungen sind zentrale Vorsorgemaßnahmen des Kindesalters, wobei bisher keine quantitativen Angaben zu deren wechselseitiger Akzeptanz vorlagen. Ziel dieser Studie war die Quantifizierung dieser Verteilungsmuster und Identifikation von Assoziationen zwischen Vorsorgeuntersuchungen und definierten Routineimpfungen bei Einschulungskindern unter Berücksichtigung des sozialen Umfeldes.
Methodik Im Rahmen der Schuleingangsuntersuchungen 2015 wurden unter anderem die dokumentierte U-Vorsorgeuntersuchungen und Routineimpfungen auf Stadtebene erfasst. Begleitend wurde ein freiwillig auszufüllender Proxy-Fragebogen an die Fürsorgeberechtigten der Einschulungskinder ausgegeben, um ergänzend Merkmale der familiären Lebensverhältnisse zu erfassen. Unter Verwendung von SPSS 25.0 wurden die Teilnahmequoten aller U-Vorsorgeuntersuchungen und definierter Routineimpfungen nebst spezifischer Kreuzprävalenzen und Risikoschätzer errechnet.
Ergebnisse Von den 407 Einschulungskindern wurden bei 76,8% der Vorschulkinder beide Präventionsmaßnahmen vollständig durchgeführt, wobei innerhalb der gesamten Studienkohorte von 280 (68,8%) ein Zusatzfragebogen abgegeben wurde. Am häufigsten hatten in Deutschland geborene Kinder zu 70,3% und zu 69,7% mit deutscher Nationalität komplette Vorsorgeuntersuchungen mit zugleich vollständigem Impfstatus. Hinsichtlich des familiären Umfeldes hatten Kinder mit Geschwistern (17,5%), Kinder mit getrenntlebenden Elternteilen (13,3%) und Familien mit bis zu 4 näheren Angehörigen (7,1%) deutlich seltener alle Vorbeugemaßnahmen komplett als andere. Die stärksten Assoziationen in Hinblick auf unvollständige Vorsorgeuntersuchungen waren für ein nichtdeutsches Geburtsland des Kindes (OR=7,95) und für eine nichtdeutsche Nationalität mindestens eines Elternteiles (OR=4,52) vorzufinden.
Schlussfolgerungen Die identifizierten Verteilungsmuster und Assoziationen lieferten neue Erkenntnisse für die Etablierung von risikogruppenspezifischen Maßnahmen zur Steigerung der Akzeptanz sowohl bei U-Vorsorgeuntersuchungen als auch in Hinblick auf definierte Routineimpfungen. Dadurch kann eine bedarfsoptimierte Gesundheitsversorgung bei Kindern im Sinne eines sozialkompensatorischen Ansatzes ermöglicht werden.
Mariendistel – Arzneipflanze des Jahres 2021 in Österreich
Authors: Chrubasik-Hausmann Sigrun 
Published: April 2021

SummaryObwohl schon im Mittelalter bei Lebererkrankungen genutzt, ist die klinische Wirksamkeit immer noch nicht zweifelsfrei belegt – auch nicht für andere vielversprechende Indikationen
Erhöhte Leberwerte
Authors: Holstege Axel 
Published: April 2021

SummaryErhöhte Leberwerte sind ein häufiger klinischer Befund, der bei symptomatischen Patienten, aber auch als symptomloser Zufallsbefund auftreten kann. Der vorliegende Beitrag erläutert, wie das Muster bestimmter pathologisch veränderter Leberwerte bereits eine erste differenzialdiagnostische Eingliederung ermöglicht und in welchen Fällen eine weiterführende Diagnostik notwendig ist.
Failure of the Ottawa Score to Predict the Risk of Recurrent Venous Thromboembolism in Cancer Patients: The Prospective PREDICARE Cohort Study
Authors: Girard Philippe , Laporte Silvy , Chapelle Céline , Falvo Nicolas , Falchero Lionel , Cloarec Nicolas , Monnet Isabelle , Burnod Alexis , Tomasini Pascale , Boulon Carine , Debourdeau Philippe , Boutruche Bettina , Scotté Florian , Lamblin Anne , Meyer Guy 
Published: April 2021

Abstract
Introduction Recurrent venous thromboembolism (VTE) despite curative anticoagulation is frequent in patients with cancer. Identifying patients with a high risk of recurrence could have therapeutic implications. A prospective study was designed to validate the Ottawa risk score of recurrent VTE in cancer patients.
Methods In a prospective multicenter observational cohort, adult cancer patients with a recent diagnosis of symptomatic or incidental lower limb deep vein thrombosis or pulmonary embolism (PE) were treated with tinzaparin for 6 months. The primary endpoint was the recurrence of symptomatic or asymptomatic VTE within the first 6 months of treatment. All clinical events were centrally reviewed and adjudicated. Time-to-event outcomes were estimated by the Kalbfleisch and Prentice method to take into account the competing risk of death. A C-statistic value of > 0.70 was needed to validate the Ottawa score.
Results A total of 409 patients were included and analyzed on an intention-to-treat basis. Median age was 68 years, 60.4% of patients had PE, and VTE was symptomatic in 271 patients (66.3%). The main primary sites were lung (31.3%), lower digestive tract (14.4%), and breast (13.9%) cancers. The Ottawa score was high (≥ 1) in 58% of patients. The 6-month cumulative incidence of recurrent VTE was 7.3% (95% confidence interval [CI]: 4.9–11.1) overall, and 5.0% (95% CI: 2.3–10.8) versus 9.1% (95%CI: 6.1–13.6) in the Ottawa low versus high risk groups, respectively. The C-statistic value was 0.60 (95% CI: 0.55–0.65).
Conclusion In this prospective cohort of patients with cancer receiving tinzaparin for VTE, the Ottawa score failed to accurately predict recurrent VTE.
Fibrinolysis in Traumatic Brain Injury: Diagnosis, Management, and Clinical Considerations
Authors: Anderson Taylor N. , Farrell David H. , Rowell Susan E. 
Published: April 2021

AbstractPosttraumatic coagulopathy involves disruption of both the coagulation and fibrinolytic pathways secondary to tissue damage, hypotension, and inflammatory upregulation. This phenomenon contributes to delayed complications after traumatic brain injury (TBI), including intracranial hemorrhage progression and systemic disseminated intravascular coagulopathy. Development of an early hyperfibrinolytic state may result in uncontrolled bleeding and is associated with increased mortality in patients with TBI. Although fibrinolytic assays are not routinely performed in the assessment of posttraumatic coagulopathy, circulating biomarkers such as D-dimer and fibrin degradation products have demonstrated potential utility in outcome prediction. Unfortunately, the relatively delayed nature of these tests limits their clinical utility. In contrast, viscoelastic tests are able to provide a rapid global assessment of coagulopathy, although their ability to reliably identify disruptions in the fibrinolytic cascade remains unclear. Limited evidence supports the use of hypertonic saline, cryoprecipitate, and plasma to correct fibrinolytic disruption; however, some studies suggest more harm than benefit. Recently, early use of tranexamic acid in patients with TBI and confirmed hyperfibrinolysis has been proposed as a strategy to further improve clinical outcomes. Moving forward, further delineation of TBI phenotypes and the clinical implications of fibrinolysis based on phenotypic variation is needed. In this review, we summarize the clinical aspects of fibrinolysis in TBI, including diagnosis, treatment, and clinical correlates, with identification of targeted areas for future research efforts.
Fundamentals of Wound Healing
Authors: Stallworth Christian L. 
Published: April 2021

AbstractAt the moment of soft tissue injury, an immediate wound healing ballet commences. This coordinated cascade of events works over minutes, hours, weeks, and months to restore tissue integrity and viability in an attempt to rebuild the site to its preinjured state. A thorough understanding of these processes, and options to navigate forks in the road, can help guide patient selection, surgical planning and execution, management of complications, and ultimately the restoration of tissue form and function for optimal outcomes. An exhaustive account of tissue healing mechanics is beyond the scope of this writing. However, a summation of much that is known of these processes and the directions research and therapeutic developments are currently aimed will help the facial plastic surgeon prevent or minimize debilitating functional and cosmetic consequences in the head and neck.
Trials and Tribulations: mHealth Clinical Trials in the COVID-19 Pandemic
Authors: Indraratna Praveen , Biswas Uzzal , Yu Jennifer , Schreier Guenter , Ooi Sze-Yuan , Lovell Nigel H. , Redmond Stephen J. 
Published: April 2021

Introduction: Mobile phone-based interventions in cardiovascular disease are growing in popularity. A randomised control trial (RCT) for a novel smartphone app-based model of care, named TeleClinical Care - Cardiac (TCC-Cardiac), commenced in February 2019, targeted at patients being discharged after care for an acute coronary syndrome or episode of decompensated heart failure. The app was paired to a digital sphygmomanometer, weighing scale and a wearable fitness band, all loaned to the patient, and allowed clinicians to respond to abnormal readings. The onset of the COVID-19 pandemic necessitated several modifications to the trial in order to protect participants from potential exposure to infection. The use of TCC-Cardiac during the pandemic inspired the development of a similar model of care (TCC-COVID), targeted at patients being managed at home with a diagnosis of COVID-19.
Methods: Recruitment for the TCC-Cardiac trial was terminated shortly after the World Health Organization announced COVID-19 as a global pandemic. Telephone follow-up was commenced, in order to protect patients from unnecessary exposure to hospital staff and patients. Equipment was returned or collected by a ‘no-contact’ method. The TCC-COVID app and model of care had similar functionality to the original TCC-Cardiac app. Participants were enrolled exclusively by remote methods. Oxygen saturation and pulse rate were measured by a pulse oximeter, and symptomatology measured by questionnaire. Measurement results were manually entered into the app and transmitted to an online server for medical staff to review.
Results: A total of 164 patients were involved in the TCC-Cardiac trial, with 102 patients involved after the onset of the pandemic. There were no hospitalisations due to COVID-19 in this cohort. The study was successfully completed, with only three participants lost to follow-up. During the pandemic, 5 of 49 (10%) of patients in the intervention arm were readmitted compared to 12 of 53 (23%) in the control arm. Also, in this period, 28 of 29 (97%) of all clinically significant alerts received by the monitoring team were managed successfully in the outpatient setting, avoiding hospitalisation. Patients found the user experience largely positive, with the average rating for the app being 4.56 out of 5. 26 patients have currently been enrolled for TCC-COVID. Recruitment is ongoing. All patients have been safely and effectively monitored, with no major adverse clinical events or technical malfunctions. Patient satisfaction has been high.
Conclusion: The TCC-Cardiac RCT was successfully completed despite the challenges posed by COVID-19. Use of the app had an added benefit during the pandemic as participants could be monitored safely from home. The model of care inspired the development of an app with similar functionality designed for use with patients diagnosed with COVID-19.
Managing Pandemic Responses with Health Informatics – Challenges for Assessing Digital Health Technologies
Authors: Magrabi Farah , Ammenwerth Elske , Craven Catherine K. , Cresswell Kathrin , De Keizer Nicolet F. , Medlock Stephanie K. , Scott Philip J. , Wong Zoie Shui-Yee , Georgiou Andrew 
Published: April 2021

Objectives: To highlight the role of technology assessment in the management of the COVID-19 pandemic.
Method: An overview of existing research and evaluation approaches along with expert perspectives drawn from the International Medical Informatics Association (IMIA) Working Group on Technology Assessment and Quality Development in Health Informatics and the European Federation for Medical Informatics (EFMI) Working Group for Assessment of Health Information Systems.
Results: Evaluation of digital health technologies for COVID-19 should be based on their technical maturity as well as the scale of implementation. For mature technologies like telehealth whose efficacy has been previously demonstrated, pragmatic, rapid evaluation using the complex systems paradigm which accounts for multiple sociotechnical factors, might be more suitable to examine their effectiveness and emerging safety concerns in new settings. New technologies, particularly those intended for use on a large scale such as digital contract tracing, will require assessment of their usability as well as performance prior to deployment, after which evaluation should shift to using a complex systems paradigm to examine the value of information provided. The success of a digital health technology is dependent on the value of information it provides relative to the sociotechnical context of the setting where it is implemented.
Conclusion: Commitment to evaluation using the evidence-based medicine and complex systems paradigms will be critical to ensuring safe and effective use of digital health technologies for COVID-19 and future pandemics. There is an inherent tension between evaluation and the imperative to urgently deploy solutions that needs to be negotiated.
Multidisciplinary Sprint Program Achieved Specialty-Specific EHR Optimization in 20 Clinics
Authors: Sieja Amber , Kim Eric , Holmstrom Heather , Rotholz Stephen , Lin Chen Tan , Gonzalez Christine , Arellano Cortney , Hutchings Sarah , Henderson Denise , Markley Katie 
Published: April 2021

Abstract
Objective The objective of the study was to highlight and analyze the outcomes of software configuration requests received from Sprint, a comprehensive, clinic-centered electronic health record (EHR) optimization program.
Methods A retrospective review of 1,254 Sprint workbook requests identified (1) the responsible EHR team, (2) the clinical efficiency gained from the request, and (3) the EHR intervention conducted.
Results Requests were received from 407 clinicians and 538 staff over 31 weeks of Sprint. Sixty-nine percent of the requests were completed during the Sprint. Of all requests, 25% required net new build, 73% required technical investigation and/or solutions, and 2% of the requests were escalated to the vendor. The clinical specialty groups requested a higher percentage of items that earned them clinical review (16 vs. 10%) and documentation (29 vs. 23%) efficiencies compared with their primary care colleagues who requested slightly more order modifications (22 vs. 20%). Clinical efficiencies most commonly associated with workbook requests included documentation (28%), ordering (20%), in basket (17%), and clinical review (15%). Sprint user requests evaluated by ambulatory, hardware, security, and training teams comprised 80% of reported items.
Discussion Sprint requests were categorized as clean-up, break-fix, workflow investigation, or new build. On-site collaboration with clinical care teams permitted consensus-building, drove vetting, and iteration of EHR build, and led to goal-driven, usable workflows and EHR products.
Conclusion This program evaluation demonstrates the process by which optimization can occur and the products that result when we adhere to optimization principles in health care organizations.
Introduction: The nature of political opposition in contemporary electoral democracies and autocracies
Authors: Helms Ludger 
Published: April 2021

AbstractAt the level of regime typologies, the uncertain status and inherent weakness of the opposition mark defining features of regimes beyond liberal democracy. However, even the performance and evolution of the latter tend to be shaped by oppositions and the regime’s approach to dealing with them. This article offers a bird’s-eye view of political oppositions in contemporary electoral democracies and competitive autocracies. It focuses on patterns of strategic choices and behavior by both governments and oppositions. That endeavor forms part of a larger joint venture seeking to give center stage to those actors living in the shadows of increasingly unscrupulous power-holders.
Momordica balsamina (common balsam apple).
Authors: Duenas-Lopez Manuel Angel 
Published: April 2021

Abstract

Momordica balsamina is native to South Africa and tropical Africa, tropical Asia, Arabia, India and Australia. It is a trailing or climbing annual or perennial tendril-bearing herb. Introduced in parts of the Neotropics and North America and Pakistan, M. balsamina has been introduced intentionally, occurring in the wild as an escapee from cultivation. This species is used for medicinal purposes. M. balsamina is reported as an invasive species in India. It is very invasive in northern Australia, where it is found in highly disturbed habitats, outcompeting native vegetation. In Florida, gardeners have reported it as a noxious weed in gardens and allotments.
Exact Solution for an Elastic Square Plate Loaded with Tangential Stresses
Authors: Menshova I V , Kerzhaev A P , Yu G , Zeng X 
Published: April 2021

Abstract
This paper provides an exact solution to the boundary value problem of elasticity theory for a square loaded with tangential stresses along all its sides (even-symmetric deformation with respect to the central axes). The solution is represented as series in Papkovich–Fadle eigenfunctions. The coefficients of the series are determined by simple closed formulas.
Business Process Improvement (BPI) with Enterprise Resource Planning (ERP) Financial & Control (FICO) and Procurement Modules Using SAP S/4 HANA to Handle Non-Banking Processes in Case Study: PT Bank Mantap
Authors: Utomo Sasmito Budi , Yuliani Eka Widya , Wulandari Nita 
Published: April 2021

Abstract
PT Bank Mantap is a private bank that manages pension funds in Indonesia. Currently, banking and non-banking process are handled by the Core Banking application. However, in the non-banking process, it is just limited in making a journal, the other non-banking processes are still done manually, so it takes a long time. This is causes various problem, such as the results of calculation of transaction data are less accurate, the process of making journals takes a long time, information between Finance and Procurement department is not integrated and the purchase request form is not standardized. From those problems, PT Bank Mantap has difficulty analyzing its financial data. Therefore, PT Bank Mantap conducts Business Process Improvement (BPI) by improving existing business processes by implementing Enterprise Resource Planning (ERP) Finance & Controlling (FICO) and Procurement modules using SAP S/4 HANA. It is the latest generation of the business suite from SAP that can help customers to simplify the company business process in an integrated environment. The results of this implementation can solve the problems encountered in which business processes become more effective, integrated, and the calculation results of transaction data become more accurate.
Determinants Effectiveness Information Technology Governance in Higher Education Institution (HEI) using partial least squares structural equation modeling approach (PLS-SEM)
Authors: Fattah Anwar , Setyadi Resad 
Published: April 2021

Abstract
Information technology supports the achievement of business organization objectives. The Higher Education institution is a business organization engaged in the field of education. Effective IT governance will ensure alignment between IT and business goals. Organizations with ineffective IT governance will suffer due to poor performance of IT resources such as inaccurate information quality, inefficient operating costs, runaway IT project and even the demise of its IT department. This study seeks to examine empirically the individual IT governance mechanisms that influence the overall effectiveness of IT governance. Furthermore, this study examines the relationship of effective IT governance and IT Innovation within the Higher education organizations. The sampling technique to be carried out in this study is a multi-stage purposeful random sampling. In sequence, researchers will combine surveys through online. The quantitative data were analyzed by the smallest partial quadratic structural equation method (PLS-SEM) using Smart PLS 3.0. The results obtained from this dataset show a positive significant relationship between effective IT governance and the following mechanisms: IT Steering Committee, Involvement of Senior management in IT, and Organizational Communication System. Also a positive relationship between ITG Effectiveness within IT Innovation. Organizational Communication System and IT Innovation have a positive significant relationship, and negative relationship with insignificant for Organizational Performance Measurement System.
A Tourist Tracking Model by Tourist Bureau
Authors: Rusdi Jack Febrian , Salam Sazilah , Abu Nur Azman , Sunaryo Budi , Naseer Muchammad , Setiawan Awan , Kchouri Mohammad , Taufiq Rohmat , Respati Rella Dwi , Alam Sitti Nur , Sarah Siti , Rusmartiana Arlinda , Rahmawati Sri 
Published: April 2021

Abstract
Tour guides are the critical services for the Travel Bureau. Especially for the services, they provide to tourists. So, a realtime system is needed to be able to interact between the two parties, especially regarding service records in the field and information processing for the Bureau. Based on ScienceDirect library, unfortunately, until there was no reporting system facilitate both parties and recorded in realtime. This study discusses software development solutions that receive various field notes by workers and can be directly viewed online for employers. This research is in the form of a reporting model, which is a solution for the Travel Bureau to have data and be stored electronically on the server. The system was built using a platform that is on a smartphone, so the tour guide reporting system becomes a solution for the Travel Bureau and the Tour Guide to document the trips carried out.