bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geometric Mediator Structures, Transition Dynamics and Force Constants
Authors: Koehler Dale. R. 
Published: December 2021

Abstract
It is shown in the present work that the distorted-space model of matter can describe conventional force-constants and transition-mediator structures. We use the verbiage “distorted” to communicate the concept of “energetic warping” to distinguish “spatial warping” from “classical matter warping”, although the concept of “matter” is in fact, in the present context, the “geometric distortion energy” of the spatial manifold itself without a classical “matter stressenergy source”. The “distorted-geometry” structures exhibit non-Newtonian features wherein the hole or core-region fields of the structures are energetically-repulsive (negative pressure), do not behave functionally in an r -4 manner and terminate at zero at the radial origin (no singularity). Near the core of the distortion the magnetic fields dominate the energy-densities of the structures thereby departing from classical particle-structure descriptions. Black-body radiation-emission and structural modeling lead to a description of transition dynamics and photonic entities.
Revealing Fano Combs in Directional Mie Scattering
Authors: Marmolejo Javier , Canales Adriana , Hanstorp Dag , Méndez-Fragoso Ricardo 
Published: December 2021

Abstract
The constructive interference of light reflecting on the inner surface of a dielectric sphere results in a rich Mie scattering spectrum. Each resonance can be understood through a quantum-mechanical analogy, while the structure of the full spectrum is predicted to be a series of Fano resonances. However, the overlap of all the different modes results in such a complex spectrum that an intuitive understanding of the full, underlying structure is still missing. Here we present a directional Mie spectrum obtained by selecting a particular polarization and direction of the scattering of levitating water droplets. We find a significantly simplified spectrum organized in distinct, consecutive Mie Fano Combs composed of equidistant resonances that smoothly evolve from wide Lorentzians into sharp Fano profiles. We then fully explain all these characteristics by expanding on the quantum-mechanical analogy. This makes it possible to understand Mie spectra intuitively without the need for computational simulations.
Pilot Remote Clinical Communication Skill Session During COVID-19 Pandemic: Medical Education in New Normal
Authors: Rasalingam Gajarishiyan 
Published: December 2021

Abstract
IntroductionClinical Communication teaching has relied heavily on face-to-face teaching using Patient Partners. The current situation with COVID-19 has led to lockdown, social isolation and travel difficulty. This leads to challenges in delivering this teaching. The study aim is to pilot a clinical communication teaching session remotely, using a virtual learning environment and video conferencing. This study evaluates the pilot about achieving learning outcomes on Musculo Skeleton disease and experience of student’s and patient partner.MethodsMixed qualitative and quantitative data are obtained through an online survey. The thematic framework is used to analyse the qualitative data and the descriptive statistics are used to evaluate the quantitative responses. Results The study provided satisfaction on proceeding this new pilot remote communication session to the routine medical curriculum, with 100% recommendation by the students. The majority of students had transformed their theoretical knowledge in the Musculo Skeleton disease system to consult with patient partners. The study also finds some gaps such as delays due to internet and device faults, limited time to build rapport with patients, nonverbal expressions are not being conveyed via the screen and difficulties in adapting to new remote sessions in short transition.ConclusionLooking into the future of new normal. Remote clinical communication session worked well during the pilot study. New innovatory methods in delivering remote teaching and more studies on different diseases topics should be implemented to analyse the sustainability and validity of the remote session for continuous delivery in medical education.
Classifying Grains Using Behaviour-Informed Machine Learning
Authors: Laudari Sudip , Marks Benjy , Rognon Pierre 
Published: December 2021

Abstract
Sorting granular materials such as ores, coffee beans, cereals, gravels and pills is essential forapplications in mineral processing, agriculture and waste recycling. Existing sorting methods are based on the detection of contrast in grain properties including size, colour, density and chemical composition. However, many grain properties cannot be directly detected in-situ, which significantly impairs sorting efficacy. We show here that a simple neural network can infer contrast in a wide range of grain properties by detecting patterns in their observable kinematics. These properties include grain size, density, stiffness, friction, dissipation and adhesion. This method of classification based on behaviour can significantly widen the range of granular materials that can be sorted. It can similarly be applied to enhance the sorting of other particulate materials including cells and droplets in microfluidic devices.
The Association Between Helicobacter Pylori Infection and Erosive Gastroesophageal Reflux Disease; a Cross-Sectional Study
Authors: Niknam Ramin , Lankarani Kamran Bagheri , Moghadami Mohsen , Taghavi Seyed Alireza , Zahiri Leila , Fallahi Mohammad Javad 
Published: December 2021

Abstract
Background
The association between H. pylori (Helicobacter pylori) infection and gastroesophageal reflux disease (GERD) is a complex and confusing subject, so we designed this study.
Method
In a cross-sectional study, all patients referred for endoscopy due to dyspepsia were enrolled. The diagnosis of erosive GERD was made by endoscopy. Patients with normal esophagus were selected as comparison group. Random gastric biopsies were taken from all participants to diagnose H. pylori infection.
Result
In total, 1916 patients were included in this study, of whom 45.6% had GERD. The mean age (SD) was 42.95 (16.32). Overall, 1442 (75.3%) patients were positive for H. pylori infection. The frequency of H. pylori infection in mild GERD patients was higher than the severe GERD, but this difference was not significant (P=0.214). Except for sociodemographic status (P < 0.001), other variables including gender, age, ethnicity, body mass index (BMI), smoking, and presence of hiatus hernia in patients had no significant association with the frequency of H. pylori infection. According to Robust Poisson regression models analysis, the association of H. pylori (PR 1.026;95%CI 0.990-1.064; P=0.158) and sociodemographic status were not significantly different between the two groups. But smoking, increased BMI, older age, presence of hiatus hernia, and peptic ulcer diseases were significantly associated with GERD compared with the non-GERD group.
Conclusion
In our results, there was no association between H. pylori infection and erosive GERD. Further studies are recommended, especially considering the effects of pathophysiological and other confounding factors on H. pylori and GERD.
De Novo Transcriptome Assembly and Development of EST-SSR Markers for Pterocarpus Santalinus L. f. (Red sanders) , a Threatened and Endemic Timber Tree of India
Authors: Agastikumar Sindhu , Patturaj Maheswari , Samji Aghila , Aiyer Balasubramanian , Munnusamy Aiswarya , Kannan Nithishkumar , Arivazhagan Vijayakumar , Warrier Rekha R , Yasodha Ramasamy 
Published: December 2021

Abstract
The endemic and precious timber Pterocarpus santalinus L. f. (Red sanders) is a drought hardy tree species for conservation in peninsular India due to its high risk of illegal timber harvest. It is only found in Eastern Ghats of India, and has become threatened owing to overexploitation of its valuable timber. The development of genomic resources, particularly simple sequence repeat (SSR) markers, is essential for strict implementation of in situ conservation measures and application of DNA information based red sanders genetic resource management. However, a lack of genomic data and efficient molecular markers limit the study of its spatial and temporal population genetic structure, identification of diversity hotspots and tree improvement. The current study aims at comprehensive molecular characterization of red sanders and the somatic chromosome counts, flow cytometry and EST-SSR analyses. The results revealed that red sanders is diploid with 2n=20 and the 2C genome size was 0.7872 ± 0.0561pg for the first time in this species. A total of 3128 EST-SSRs were detected based on 25,854 de novo assembled unigenes from transcriptome data and primer sets designed for 1953 SSRs. Fifty-nine EST-SSR markers were evaluated for polymorphism in the natural populations of red sanders and 13 were found to be suitable for genetic analysis. Two major transcription factor families bHLH and ERF, responsible for abiotic stress and secondary metabolite synthesis were analysed which would provide the foundation for further research on production of medicinally important biocompounds.
Controlling the Twisted Intramolecular Charge-Transfer Character of Pyrene Derivatives Through Solvent Polarity
Authors: Sung Young Mo , Kwon Eun Suk , Maruyama Yusuke Makida , Shin Youngsik , Ihn Soo-Ghang , Kim Jong Soo , Choi Hyeonho , Lee Hyo Sug , Kim Jung-Hwa , Kim Joonghyuk , Sul Soohwan 
Published: December 2021

Abstract
Intramolecular charge transfer (ICT) plays a critical role in determining the photophysical properties of organic molecules, including their luminescence efficiencies. Twisted intramolecular charge transfer (TICT) is a process in which structural change accompanies ICT. Despite significant research, the relationship between TICT and solvent polarity, and its effects on photophysical properties, have been rarely investigated. Herein, we used time-resolved spectroscopy to study TICT in pyrene derivatives that are promising blue organic light emitting diode (OLED) emitter candidates; these derivatives show strong solvent-dependent charge-transfer (CT) behavior. Slight structural changes that do not affect excited state dynamics were observed in nonpolar solvents, while polar solvents were found to affect excited state dynamics and CT characteristics. The TICT behavior of these pyrene derivatives could be modulated through structural modification. Our study provides valuable guidelines for the control of optical properties, including the luminescence efficiencies of OLED emitters that show TICT characteristics.
Transposable elements mediate genetic effects altering the expression of nearby genes in colorectal cancer
Authors: Lykoskoufis Nikolaos , Planet Evarist , Ongen Halit , Trono Didier , Dermitzakis Emmanouil T 
Published: December 2021

Abstract
Transposable elements (TEs) are interspersed repeats that contribute to more than half of the human genome, and TE-embedded regulatory sequences are increasingly recognized as major components of the human regulome. Perturbations of this system can contribute to tumorigenesis, but the impact of TEs on gene expression in cancer cells remains to be fully assessed. Here, we analyzed 275 normal colon and 276 colorectal cancer (CRC) samples from the SYSCOL colorectal cancer cohort and discovered 10,111 and 5,152 TE expression quantitative trait loci (eQTLs) in normal and tumor tissues, respectively. Amongst the latter, 376 were exclusive to CRC, likely driven by changes in methylation patterns. We identified that transcription factors are more enriched in tumor-specific TE-eQTLs than shared TE-eQTLs, indicating that TEs are more specifically regulated in tumor than normal. Using Bayesian Networks to assess the causal relationship between eQTL variants, TEs and genes, we identified that 1,758 TEs are mediators of genetic effect, altering the expression of 1,626 nearby genes significantly more in tumor compared to normal, of which 51 are cancer driver genes. We show that tumor-specific TE-eQTLs trigger the driver capability of TEs subsequently impacting expression of nearby genes. Collectively, our results highlight a global profile of a new class of cancer drivers, thereby enhancing our understanding of tumorigenesis and providing potential new candidate mechanisms for therapeutic target development.
Physiological microbial exposure has a temporally limited inhibitory effect on lung ILC2 responses to allergens in mice
Authors: Jameson Stephen , Block Katharine , Iijima Koji , Pierson Mark , Walsh Daniel , Tei Rinna , Kucaba Tamara , Xu Julie , Griffith Thomas , McSorley Henry , Kita Hirohito 
Published: December 2021

Abstract
The impact of microbes on restraining the immune response to allergens has been extensively studied and is a key element of the hygiene hypothesis. Lung type 2 innate lymphoid cell responses to airway allergens can be inhibited by administration of a number of microbial products; however, it is unclear whether such an effect would be observed with natural infections and how sustained any observed inhibitory effects would be. To answer these questions, we used a murine model of physiological microbial exposures through cohousing SPF laboratory mice with pet store mice and examined the acute type 2 response to intranasally delivered fungal allergen extract Alternaria alternata. We found laboratory mice cohoused with pet store mice for two weeks display a suppressed ILC2 response to A. alternata which resulted in reduced eosinophilia. By comparison, mice cohoused for at least two months had ILC2 and eosinophil responses similar to SPF mice despite dramatic changes to the composition of the immune cell populations in the lungs. Lung ILC2 in two-month cohoused mice were still sensitive to subsequent inflammatory cues, as administration of poly(I:C) was able to suppress ILC2 activation and eosinophilia equally well in SPF and two-month cohoused animals. These findings suggest ILC2 dynamically respond to their environment and are not easily desensitized long-term.
Serum Markers of Cardiac Complications In a Systemic Sclerosis Cohort
Authors: Tennøe Anders Heiervang , Murbræch Klaus , Didriksen Henriette , Ueland Thor , Palchevskiy Vyacheslav , Weigt Stephen , Fretheim Håvard , Midtvedt Øyvind , Garen Torhild , Brunborg Cathrine , Aukrust Pål , Molberg Øyvind , Belperio John , Hoffmann-Vold Anna-Maria 
Published: December 2021

Abstract
Background: Primary cardiac involvement is one of the leading causes of mortality in systemic sclerosis (SSc), but little is known regarding circulating biomarkers for cardiac SSc. Here, we aimed to investigate potential associations between cardiac SSc and candidate serum markers.Methods: Serum samples from patients of the Oslo University SSc cohort and 100 healthy controls were screened against two custom-made candidate marker panels containing molecules deemed relevant for cardiopulmonary and/or fibrotic diseases. Left (LV) and right ventricular (RV) dysfunction was assessed by protocol echocardiography, performed within three years from serum sampling. Patients suspected of pulmonary hypertension underwent right heart catheterization. Vital status at study end was available for all patients. Descriptive analyses, logistic and Cox regressions were conducted to assess associations between cardiac SSc and candidate serum markers. Results: The 371 patients presented an average age of 57.2 (± 13.9) years. Female sex (84%) and limited cutaneous SSc (73%) were predominant. Association between LV diastolic dysfunction and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) (OR 0.41, 95%CI 0.21-0.78, p=0.007) was identified. LV systolic dysfunction defined by global longitudinal strain was associated with angiopoietin 2 (ANGPT2) (OR 3.42, 95%CI 1.52-7.71, p=0.003) and osteopontin (OPN) (OR 1.95, 95%CI 1.08-3.52, p=0.026). RV systolic dysfunction, measured by tricuspid annular plane systolic excursion, was associated to markers of LV dysfunction (ANGPT2, OPN, and TRAIL) (OR 1.67, 95%CI 1.11-2.50, p=0.014, OR 1.86, 95%CI 1.25-2.77, p=0.002, OR 0.32, 95%CI 0.15-0.66, p=0.002, respectively) and endostatin (OR 1.86, 95%CI 1.22-2.84, p=0.004).Conclusion: ANGPT2, OPN and TRAIL seem to be circulating biomarkers associated with both LV and RV dysfunction in SSc.
Does Community-Based Health Insurance Protect Women from Financial Catastrophe After Cesarean Section? A Prospective Study from a Rural Hospital in Rwanda
Authors: Koch Rachel , Nkurunziza Theoneste , Rudolfson Niclas , Nkurunziza Jonathan , Bikorimana Laban , Irasubiza Holly , Sonderman Kristin , Riviello Robert , Hedt-Gauthier Bethany , Shrime Mark , Kateera Fred 
Published: December 2021

Abstract
BackgroundThe implementation of community-based health insurance in (CBHI) in Rwanda has reduced out of pocket (OOP) spending for the >79% of citizens who enroll in it but the effect for surgical patients is not well described. For all but the poorest citizens who are completely subsidized, the OOP (out of pocket) payment at time of service is 10%. However, 55.5% of the population is below the international poverty line meaning that even this copay can have a significant impact on a family’s financial health. The aim of this study was to estimate the burden of OOP payments for cesarean sections in the context of CBHI and determine if having it reduces catastrophic health expenditure (CHE). MethodsThis study is nested in a larger randomized controlled trial of women undergoing cesarean section at a district hospital in Rwanda. Eligible patients were surveyed at discharge to quantify household income and routine monthly expenditures and direct and indirect spending related to the hospitalization. This was used in conjunction with hospital billing records to calculate the rate of catastrophic expenditure by insurance group. ResultsAbout 94% of the 340 women met the World Bank definition of extreme poverty. Of the 330 (97.1%) with any type of health insurance, the majority (n=310, 91.2%) have CBHI. The average OOP expenditure for a cesarean section and hospitalization was $9.36. The average cost adding transportation to the hospital was $19.29. 164 (48.2%) had to borrow money and 43 (12.7%) had to sell possessions. The hospital bill alone was a CHE for 5.3% of patients. However, when including transportation costs, 15.4% incurred a CHE and including lost wages, 22.6%. ConclusionTo ensure universal health coverage (UHC), essential surgical care must be affordable. Despite enrollment in universal health insurance, cesarean section still impoverishes households in rural Rwanda, the majority of whom already lie below the poverty line. Although CBHI protects against CHE from the cost of healthcare, when adding in the cost of transportation, lost wages and caregivers, cesarean section is still often a catastrophic financial event. Further innovation in financial risk protection is needed to provide equitable UHC.
Peripheral Nerve Defects: Repair Using Autogenous Vein Grafts Filled with PRP and Active Nerve Microtissues and Evaluation by Novel Multimodal Ultrasound Techniques
Authors: Zhu Yaqiong , Peng Nan , Wang Jing , Jin Zhuang , Zhu Lianhua , Wang Yu , Chen Siming , Hu Yongqiang , Zhang Tieyuan , Song Qing , Xie Fang , Yan Lin , Li Yingying , Xiao Jing , Li Xinyang , Jiang Bo , Wang Yuexiang , Peng Jiang , Luo Yukun 
Published: December 2021

Abstract
Background: Developing biocompatible nerve conduits that accelerate peripheral nerve regeneration, lengthening and functional recovery remains a challenge. The combined application of nerve microtissues and platelet-rich plasma (PRP) provides abundant Schwann cells (SCs) and various natural growth factors and can compensate for the deficiency of SCs in the nerve bridge, as well as the limitations of applying a single type of growth factor. Multimodal ultrasound evaluation can provide additional information on the stiffness and microvascular flow perfusion of the tissue. This study was designed to investigate the effectiveness of a novel tissue-engineered nerve graft composed of an autogenous vein, nerve microtissues and PRP in reconstructing a 12-mm tibial nerve defect and to explore the value of multimodal ultrasound techniques in evaluating the prognosis of nerve repair. Methods: In vitro, nerve microtissue activity was first investigated, and the effects on SC proliferation, migration, factor secretion, and axonal regeneration of dorsal root ganglia (DRG) were evaluated by coculture with nerve microtissues and PRP. In vivo, seventy-five rabbits were equally and randomly divided into Hollow, PRP, Micro-T (Microtissues), Micro-T+PRP and Autograft groups. By analysing the neurological function, electrophysiological recovery, and the comparative results of multimodal ultrasound and histological evaluation, we investigated the effect of these new nerve grafts in repairing tibial nerve defects. Results: Our results showed that the combined application of nerve microtissues and PRP could significantly promote the proliferation, secretion and migration of SCs and the regeneration of axons in the early stage. The Micro-T+PRP group and Autograft groups exhibited the best nerve repair 12 weeks postoperatively. In addition, the changes in target tissue stiffness and microvascular perfusion on multimodal ultrasound (shear wave elastography; contrast-enhanced ultrasonography; Angio PlaneWave UltrasenSitive, AngioPLUS) were significantly correlated with the histological results, such as collagen area percentage and VEGF expression, respectively. Conclusion: Our novel tissue-engineered nerve graft shows excellent efficacy in repairing 12-mm defects of the tibial nerve in rabbits. Moreover, multimodal ultrasound may provide a clinical reference for prognosis by quantitatively evaluating the stiffness and microvescular flow of nerve grafts and targeted muscles.
The Research on Perioperative Blood Glucose and Insulin Levels of Patients with Single Insulinoma
Authors: Cong Lin , Jiang Rui , Cheng Xinqi , Hu Yingying , Hong Xiafei , Jiang Jialin , Wu Wenming , Zhao Yupei 
Published: December 2021

Abstract
Background The blood glucose level is an important biochemical parameter for evaluating the resection effectiveness of insulinomas. However, whether other biochemical parameters have better evaluating ability remains unclear. The current study aims to compare the evaluating capability of blood glucose and insulin levels at several aspects, such as the accuracy and response time. Methods Between September 2017 and July 2018, 21 insulinoma patients with single tumor who underwent surgical resection were enrolled. Peripheral venous blood samples were assayed for blood glucose and insulin levels on the day of surgery and at 30 minutes, 60 minutes, 1 day, and 7 days after surgery. The evaluating abilities of blood glucose and insulin levels for resection effectiveness were recorded and compared. Results The evaluating performance of the insulin level was better than that of the blood glucose level (100% for 21 patients vs 82.4% for 17 patients), as well as the response time ( p<0.0001). Furthermore, the insulin level was not effected by intravenous glucose infusion compared to the blood glucose level. Conclusions Comparing with blood glucose level, insulin level is a better parameter for evaluating resection effectiveness of insulinomas with faster response and regardless of perioperative intravenous glucose infusion.