bluuebunny/crossref_metadata_2025_split huggingface dataset:
The branded product and the funded project: the impact of economic rationality on the practices and pedagogy of music education in the early childhood sector
Authors: Young Susan 
Published: January 2021

AbstractIn this article, I explore how neoliberal economic discourses and techniques have profoundly influenced the way that music education in early childhood has developed in recent years in the UK. I focus on two dominant models of practice that have been shaped by market thinking; the private music session (the ‘branded product’) and short term, stand-alone projects funded by charitable organisations (the ‘funded project’). The prevalence of these two models has resulted in highly fragmented and unequal provision accompanied by narrow conceptions of music in early childhood that give rise to impoverished practice. While I base my discussion on the early childhood sector in the UK, this discussion can nevertheless warn music educators beyond this one sector and one location of the negative consequences of abandoning music education to market forces.
Associations between stress reactivity and behavior problems for previously institutionalized youth across puberty
Authors: Perry Nicole B. , DePasquale Carrie E. , Donzella Bonny , Gunnar Megan R. 
Published: January 2021

AbstractMegan Gunnar's pubertal stress recalibration hypothesis was supported in a recent study of previously institutionalized (PI) youth such that increases in pubertal stage were associated with increases in cortisol stress reactivity. This work provides evidence that puberty may open up a window of recalibration for PI youth, resulting in a shift from a blunted to a more typical cortisol stress response. Using the same sample (N = 132), the current study aimed to elucidate whether increases in cortisol are associated with increases in adaptive functioning or whether they further underlie potential links to developmental psychopathology. Specifically, we examined the bidirectional associations between cortisol stress reactivity and both internalizing and externalizing symptoms across three timepoints during the pubertal period. Youth reported on their own internalizing symptoms and parents reported on youths’ externalizing symptoms. Cortisol reactivity was assessed during the Trier social stress test. Analyses revealed no associations between cortisol reactivity and externalizing symptoms across puberty for PI youth. However, longitudinal bidirectional associations did emerge for internalizing symptoms such that increases in cortisol reactivity predicted increases in internalizing symptoms and increases in internalizing symptoms predicted increases in cortisol reactivity. Findings suggest that recalibrating to more normative levels of cortisol reactivity may not always be associated with adaptive outcomes for PI youth.
Stigma associated with parental depression or cancer: Impact on spouse and offspring's cortisol levels and socioemotional functioning
Authors: Lupien Sonia J. , Roy Denis-Claude , Raymond Catherine , Leclaire Sarah , Wan Nathalie , Labelle Réal , Giguère Charles-Édouard , Ouellet-Morin Isabelle 
Published: January 2021

AbstractStress associated with caring for a mentally ill spouse can adversely affect the health status of caregivers and their children. Adding to the stress of caregiving is the stigma often placed against spouses and children of people with mental illness. Contrary to mental illness, many physical disorders such as cancer may be less stigmatized (expect pulmonary cancer). In this study, we measured externalized and internalized stigma, as well as psychological (depressive symptoms and stressful life events) and physiological (basal salivary cortisol levels) markers of stress in 115 spouses and 154 children of parents suffering from major depressive disorder, cancer, or no illness (control group). The results show that spouses and children from families with parental depression present significantly more externalized stigma than spouses and children from families with parental cancer or no illness, although we find no group differences on internalized stigma. The analysis did not show a significant group difference either for spouses or their children on depressive symptomatology, although spouses from the parental depression group reported greater work/family stress. Finally, we found that although for both spouses children the awakening cortisol response was greater on weekdays than on weekend days, salivary cortisol levels did not differ between groups. Bayes factor calculated on the null result for cortisol levels was greater than 100, providing strong evidence for the null hypothesis H0. Altogether, these results suggest an impact of stigma toward mental health disorder on psychological markers of stress but no impact of stigma on physiological markers of stress. We suggest that these results may be due to the characteristics of the families who participated in the present study.
OPTIMAL LOCATION OF AN UNDERGROUND CONNECTOR USING DISCOUNTED STEINER TREE THEORY
Authors: SIRINANDA K. G. , BRAZIL M. , GROSSMAN P. A. , RUBINSTEIN J. H. , THOMAS D. A. 
Published: January 2021

AbstractThe objective of this paper is to demonstrate that the gradient-constrained discounted Steiner point algorithm (GCDSPA) described in an earlier paper by the authors is applicable to a class of real mine planning problems, by using the algorithm to design a part of the underground access in the Rubicon gold mine near Kalgoorlie in Western Australia. The algorithm is used to design a decline connecting two ore bodies so as to maximize the net present value (NPV) associated with the connector. The connector is to break out from the access infrastructure of one ore body and extend to the other ore body. There is a junction on the connector where it splits in two near the second ore body. The GCDSPA is used to obtain the optimal location of the junction and the corresponding NPV. The result demonstrates that the GCDSPA can be used to solve certain problems in mine planning for which currently available methods cannot provide optimal solutions.
Genetic and Environmental Influences of Dietary Indices in a UK Female Twin Cohort
Authors: Mompeo Olatz , Gibson Rachel , Christofidou Paraskevi , Spector Tim D. , Menni Cristina , Mangino Massimo 
Published: January 2021

AbstractA healthy diet is associated with the improvement or maintenance of health parameters, and several indices have been proposed to assess diet quality comprehensively. Twin studies have found that some specific foods, nutrients and food patterns have a heritable component; however, the heritability of overall dietary intake has not yet been estimated. Here, we compute heritability estimates of the nine most common dietary indices utilized in nutritional epidemiology. We analyzed 2590 female twins from TwinsUK (653 monozygotic [MZ] and 642 dizygotic [DZ] pairs) who completed a 131-item food frequency questionnaire (FFQ). Heritability estimates were computed using structural equation models (SEM) adjusting for body mass index (BMI), smoking status, Index of Multiple Deprivation (IMD), physical activity, menopausal status, energy and alcohol intake. The AE model was the best-fitting model for most of the analyzed dietary scores (seven out of nine), with heritability estimates ranging from 10.1% (95% CI [.02, .18]) for the Dietary Reference Values (DRV) to 42.7% (95% CI [.36, .49]) for the Alternative Healthy Eating Index (A-HEI). The ACE model was the best-fitting model for the Healthy Diet Indicator (HDI) and Healthy Eating Index 2010 (HEI-2010) with heritability estimates of 5.4% (95% CI [−.17, .28]) and 25.4% (95% CI [.05, .46]), respectively. Here, we find that all analyzed dietary indices have a heritable component, suggesting that there is a genetic predisposition regulating what you eat. Future studies should explore genes underlying dietary indices to further understand the genetic disposition toward diet-related health parameters.
Core‐Log‐Seismic Integration in Metamorphic Rocks and Its Implication for the Regional Geology: A Case Study for the ICDP Drilling Project COSC‐1, Sweden
Authors: Elger Judith , Berndt Christian , Kästner Felix , Pierdominici Simona , Kück Jochem , Almqvist Bjarne S. G. , Juhlin Christopher , Lorenz Henning 
Published: January 2021

AbstractContinental collision causes deformation in the crust along shear zones. However, the physical and chemical conditions at which these zones operate and the deformation processes that enable up to hundreds of km of tectonic transport are still unclear because of the depth at which they occur and the challenges in imaging them. Ancient exhumed collision zones allow us to investigate these processes much better, for example at the COSC‐1 borehole in the central Scandinavian Caledonides. This study combines data from the COSC‐1 borehole with different seismic measurements to provide constraints on the spatial lithological and textural configuration of the Seve Nappe Complex. This is one of the few studies that shows that core‐log‐seismic integration in metamorphic rocks allows to identify the spatial distribution of major lithological units. Especially gamma ray logs in combination with density data are powerful tools to distinguish between mafic and felsic lithologies in log‐core correlation. Our results indicate that reflections along the borehole are primarily caused by compositional rather than textural changes. Reflections in the Seve Nappe Complex are not as distinct as in greater depths but continuous and several of them can be linked to magmatic intrusions, which have been metamorphically overprinted. Their setting indicates that the Seve Nappe Complex consists of the remnants of a volcanic continental margin. Our results suggest that ductile‐deformed middle crustal reflectivity is primarily a function of pre‐orogenic lithological variations which has to be considered when deciphering mountain building processes.
A Coupled Numerical Modeling Study of a Sea Fog Case After the Passage of Typhoon Muifa Over the Yellow Sea in 2011
Authors: Kim Subin , Moon Jae‐Hong , Kim Taekyun 
Published: January 2021

AbstractSatellite remote sensing data revealed a widespread sea fog event over the central/southern Yellow Sea (YS), following Typhoon Muifa passage in August 2011. Despite the importance of sea fog prediction for coastal safety, improving accuracy remains a challenging issue. By analyzing results from air‐sea coupled and uncoupled simulations, this study aims to investigate how the air‐sea coupling improves the sea fog formation and duration and examine atmospheric responses to spatiotemporally varying sea surface temperature (SST) over the YS. Unlike the uncoupled model, the SST simulated by the coupled model dramatically decreased and maintained its low temperature for more than a week after the typhoon passed over the YS, showing better agreement with the observations. The sharp SST decrease over the YS cools the air temperature at low‐level atmosphere and enhances horizontal convergence in the moisture flux over the cooler ocean, which provides favorable conditions for sea fog formation. The long‐lasting oceanic cooling stabilizes the atmospheric boundary layer and suppresses atmospheric vertical mixing, delaying the dissipation of sea fog for more than a week. This study highlights that air‐sea coupling can improve the sea fog simulation by providing more realistic oceanic conditions.
Evidence of Exposed Dusty Water Ice within Martian Gullies
Authors: Rai Khuller Aditya , Russel Christensen Philip 
Published: January 2021

AbstractMidlatitude slopes on Mars are mantled by deposits proposed to contain H2O ice and dust, overlaid by a desiccated lag. However, direct evidence of their volatile content is lacking. Here we present novel evidence of light‐toned materials within midlatitude gully alcoves eroded into these mantles. The appearance and Lambert albedo of these materials suggests that they are either dust or H2O ice. We interpret them to be H2O ice because it is unlikely for a short‐term, localized dust deposit to form only within the mantle walls. The temperatures are generally too warm (>∼240 K) for the ice to be a frost in equilibrium. Therefore, this ice is likely similar to the dusty ice documented within midlatitude scarps, but with more dust, and exposed in smaller patches by slumping. It has been proposed that CO2 frosts remove the overlying lag, causing the exposed H2O ice to sublimate, liberate dust within the ice for transport, and erode gullies in the mantle. But we observe gullies eroded in wall rock that continue into the mantle, implying that the same process erodes both substrates. H2O ice melt can explain gullies eroded in the wall rock and the mantle. Numerical models show that relatively dense H2O snow on Mars melts only when it contains small amounts of dust. The observed exposure of dusty ice provides a mechanism for it to melt under some conditions and form some gullies. Access to liquid water within this ice could provide potential abodes for any extant life.
Vertically Resolved Magma Ocean–Protoatmosphere Evolution: H2, H2O, CO2, CH4, CO, O2, and N2as Primary Absorbers
Authors: Lichtenberg Tim , Bower Dan J. , Hammond Mark , Boukrouche Ryan , Sanan Patrick , Tsai Shang‐Min , Pierrehumbert Raymond T. 
Published: January 2021

AbstractThe earliest atmospheres of rocky planets originate from extensive volatile release during magma ocean epochs that occur during assembly of the planet. These establish the initial distribution of the major volatile elements between different chemical reservoirs that subsequently evolve via geological cycles. Current theoretical techniques are limited in exploring the anticipated range of compositional and thermal scenarios of early planetary evolution, even though these are of prime importance to aid astronomical inferences on the environmental context and geological history of extrasolar planets. Here, we present a coupled numerical framework that links an evolutionary, vertically resolved model of the planetary silicate mantle with a radiative‐convective model of the atmosphere. Using this method, we investigate the early evolution of idealized Earth‐sized rocky planets with end‐member, clear‐sky atmospheres dominated by either H2, H2O, CO2, CH4, CO, O2, or N2. We find central metrics of early planetary evolution, such as energy gradient, sequence of mantle solidification, surface pressure, or vertical stratification of the atmosphere, to be intimately controlled by the dominant volatile and outgassing history of the planet. Thermal sequences fall into three general classes with increasing cooling timescale: CO, N2, and O2with minimal effect, H2O, CO2, and CH4with intermediate influence, and H2with several orders of magnitude increase in solidification time and atmosphere vertical stratification. Our numerical experiments exemplify the capabilities of the presented modeling framework and link the interior and atmospheric evolution of rocky exoplanets with multiwavelength astronomical observations.
Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy
Authors: Bhat Ajaz A. , Yousuf Parvaiz , Wani Nissar A. , Rizwan Arshi , Chauhan Shyam S. , Siddiqi Mushtaq A. , Bedognetti Davide , El-Rifai Wael , Frenneaux Michael P. , Batra Surinder K. , Haris Mohammad , Macha Muzafar A. 
Published: January 2021

AbstractHead and neck squamous cell carcinoma (HNSCC) is a very aggressive disease with a poor prognosis for advanced-stage tumors. Recent clinical, genomic, and cellular studies have revealed the highly heterogeneous and immunosuppressive nature of HNSCC. Despite significant advances in multimodal therapeutic interventions, failure to cure and recurrence are common and account for most deaths. It is becoming increasingly apparent that tumor microenvironment (TME) plays a critical role in HNSCC tumorigenesis, promotes the evolution of aggressive tumors and resistance to therapy, and thereby adversely affects the prognosis. A complete understanding of the TME factors, together with the highly complex tumor–stromal interactions, can lead to new therapeutic interventions in HNSCC. Interestingly, different molecular and immune landscapes between HPV+veand HPV−ve(human papillomavirus) HNSCC tumors offer new opportunities for developing individualized, targeted chemoimmunotherapy (CIT) regimen. This review highlights the current understanding of the complexity between HPV+veand HPV−veHNSCC TME and various tumor–stromal cross-talk modulating processes, including epithelial–mesenchymal transition (EMT), anoikis resistance, angiogenesis, immune surveillance, metastatic niche, therapeutic resistance, and development of an aggressive tumor phenotype. Furthermore, we summarize the recent developments and the rationale behind CIT strategies and their clinical applications in HPV+veand HPV−veHNSCC.
Akt1-associated actomyosin remodelling is required for nuclear lamina dispersal and nuclear shrinkage in epidermal terminal differentiation
Authors: Rogerson Clare , Wotherspoon Duncan J. , Tommasi Cristina , Button Robert W. , O’Shaughnessy Ryan F. L. 
Published: January 2021

AbstractKeratinocyte cornification and epidermal barrier formation are tightly controlled processes, which require complete degradation of intracellular organelles, including removal of keratinocyte nuclei. Keratinocyte nuclear destruction requires Akt1-dependent phosphorylation and degradation of the nuclear lamina protein, Lamin A/C, essential for nuclear integrity. However, the molecular mechanisms that result in complete nuclear removal and their regulation are not well defined. Post-confluent cultures of rat epidermal keratinocytes (REKs) undergo spontaneous and complete differentiation, allowing visualisation and perturbation of the differentiation process in vitro. We demonstrate that there is dispersal of phosphorylated Lamin A/C to structures throughout the cytoplasm in differentiating keratinocytes. We show that the dispersal of phosphorylated Lamin A/C is Akt1-dependent and these structures are specific for the removal of Lamin A/C from the nuclear lamina; nuclear contents and Lamin B were not present in these structures. Immunoprecipitation identified a group of functionally related Akt1 target proteins involved in Lamin A/C dispersal, including actin, which forms cytoskeletal microfilaments, Arp3, required for actin filament nucleation, and Myh9, a component of myosin IIa, a molecular motor that can translocate along actin filaments. Disruption of actin filament polymerisation, nucleation or myosin IIa activity prevented formation and dispersal of cytoplasmic Lamin A/C structures. Live imaging of keratinocytes expressing fluorescently tagged nuclear proteins showed a nuclear volume reduction step taking less than 40 min precedes final nuclear destruction. Preventing Akt1-dependent Lamin A/C phosphorylation and disrupting cytoskeletal Akt1-associated proteins prevented nuclear volume reduction. We propose keratinocyte nuclear destruction and differentiation requires myosin II activity and the actin cytoskeleton for two intermediate processes: Lamin A/C dispersal and rapid nuclear volume reduction.
Long non-coding RNA LINC00665 promotes gemcitabine resistance of Cholangiocarcinoma cells via regulating EMT and stemness properties through miR-424-5p/BCL9L axis
Authors: Lu Min , Qin Xinglei , Zhou Yajun , Li Gang , Liu Zhaoyang , Geng Xiwen , Yue Haodi 
Published: January 2021

AbstractGemcitabine is the first-line chemotherapy drug for cholangiocarcinoma (CCA), but acquired resistance has been frequently observed in CCA patients. To search for potential long noncoding RNAs (lncRNAs) involved in gemcitabine resistance, two gemcitabine resistant CCA cell lines were established and dysregulated lncRNAs were identified by lncRNA microarray. Long intergenic non-protein coding RNA 665 (LINC00665) were found to rank the top 10 upregulated lncRNAs in our study, and high LINC00665 expression was closely associated with poor prognosis and chemoresistance of CCA patients. Silencing LINC00665 in gemcitabine resistant CCA cells impaired gemcitabine tolerance, while enforced LINC00665 expression increased gemcitabine resistance of sensitive CCA cells. The gemcitabine resistant CCA cells showed increased EMT and stemness properties, and silencing LINC00665 suppressed sphere formation, migration, invasion and expression of EMT and stemness markers. In addition, Wnt/β-Catenin signaling was activated in gemcitabine resistant CCA cells, but LINC00665 knockdown suppressed Wnt/β-Catenin activation. B-cell CLL/lymphoma 9-like (BCL9L), the nucleus transcriptional regulators of Wnt/β-Catenin signaling, plays a key role in the nucleus translocation of β-Catenin and promotes β-Catenin-dependent transcription. In our study, we found that LINC00665 regulated BCL9L expression by acting as a molecular sponge for miR-424-5p. Moreover, silencing BCL9L or miR-424-5p overexpression suppressed gemcitabine resistance, EMT, stemness and Wnt/β-Catenin activation in resistant CCA cells. In conclusion, our results disclosed the important role of LINC00665 in gemcitabine resistance of CCA cells, and provided a new biomarker or therapeutic target for CCA treament.
Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway
Authors: Fang Shaohong , Wan Xin , Zou Xiaoyi , Sun Song , Hao Xinran , Liang Chenchen , Zhang Zhenming , Zhang Fangni , Sun Bo , Li Hulun , Yu Bo 
Published: January 2021

AbstractInducing autophagy and inhibiting apoptosis may provide a therapeutic treatment for atherosclerosis (AS). For the treatment of progressive AS, arsenic trioxide (ATO) has been used to coat vascular stents. However, the effect of ATO on autophagy of macrophages is still unknown. Therefore, the aims of this study were to characterize the effects and the mechanism of actions of ATO on autophagy in macrophages. Our results showed that ATO-induced activation of autophagy was an earlier event than ATO-induced inhibition of the expression of apoptosis markers in macrophages and foam cells. Nuclear transcription factor EB (TFEB) prevents atherosclerosis by activating macrophage autophagy and promoting lysosomal biogenesis. Here, we report that ATO triggered the nuclear translocation of TFEB, which in turn promoted autophagy and autophagosome-lysosome fusion. Both the latter events were prevented by TFEB knockdown. Moreover, ATO decreased the p-AKT and p-mTOR in the PI3K/AKT/mTOR signaling pathway, thus inducing autophagy. Correspondingly, treatment with the autophagy inhibitor 3-methyladenine (3-MA) abolished the autophagy-inducing effects of ATO. Meanwhile, PI3K inhibitor (LY294002) and mTOR inhibitor (rapamycin) cooperated with ATO to induce autophagy. Furthermore, reactive oxygen species (ROS) were generated in macrophages after treatment with ATO. The ROS scavenger N-acetyl-1-cysteine (NAC) abolished ATO-induced nuclear translocation of TFEB, as well as changes in key molecules of the AKT/mTOR signaling pathway and downstream autophagy. More importantly, ATO promoted autophagy in the aorta of ApoE−/−mice and reduced atherosclerotic lesions in early AS, which were reversed by 3-MA treatment. In summary, our data indicated that ATO promoted ROS induction, which resulted in nuclear translocation of TFEB and inhibition of the PI3K/AKT/mTOR pathway. These actions ultimately promoted macrophage autophagy and reduced atherosclerotic lesions at early stages. These findings may provide a new perspective for the clinical treatment of early-stage atherosclerosis and should be further studied.