bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cortisol levels in blood and hair of unanesthetized grizzly bears (Ursus arctos) following intravenous cosyntropin injection
Authors: Cattet Marc , Janz David M. , Kapronczai Luciene , Erlenbach Joy A. , Jansen Heiko T. , Nelson O Lynne , Robbins Charles T. , Stenhouse Gordon B. 
Published: May 2021

AbstractHair cortisol concentration (HCC) is being used increasingly to evaluate long‐term stress in many mammalian species. Most of the cortisol is assumed to passively diffuse from circulating blood into hair follicles and gradually accumulate in growing hair. However, our research with free‐ranging grizzly bears (Ursus arctos) suggests HCC increases significantly within several hours following capture, a time too brief to be explained by this mechanism alone. In this study with captive grizzly bears, we sought to determine if a brief spike in blood cortisol concentration, thus mimicking a single stressful event, would cause an increase in HCC over a 7‐day period. To do this, we administered a single intravenous dose (5 μg/kg) of cosyntropin to three captive unanaesthetised adult female grizzly bears on two occasions, during April when hair growth was arrested and during August when hair was growing. In both trials, the cosyntropin caused a two‐fold or greater increase in serum cortisol levels within 1 hr but did not appear to influence HCC at 1, 48, and 168 hr following cosyntropin administration. We conclude the cosyntropin‐induced cortisol spike was likely insignificant when compared to the adrenocortical response that occurs in free‐ranging bears when captured. We suggest further study with a larger sample of captive bears to evaluate the combined effects of anaesthesia and multiple doses of cosyntropin administered over several hours would better simulate the adrenocortical response of free‐ranging grizzly bears during capture.
4-manifolds and topological modular forms
Authors: Gukov Sergei , Pei Du , Putrov Pavel , Vafa Cumrun 
Published: May 2021

Abstract
We build a connection between topology of smooth 4-manifolds and the theory of topological modular forms by considering topologically twisted compactification of 6d (1, 0) theories on 4-manifolds with flavor symmetry backgrounds. The effective 2d theory has (0, 1) supersymmetry and, possibly, a residual flavor symmetry. The equivariant topological Witten genus of this 2d theory then produces a new invariant of the 4-manifold equipped with a principle bundle, valued in the ring of equivariant weakly holomorphic (topological) modular forms. We describe basic properties of this map and present a few simple examples. As a byproduct, we obtain some new results on ’t Hooft anomalies of 6d (1, 0) theories and a better understanding of the relation between 2d (0, 1) theories and TMF spectra.
“Self-testimony of a Past Present”: Reuses of Historical Film Documents
Authors: Sattelmacher Anja 
Published: May 2021

AbstractHas the history of film digitization ever been incorporated in questions of evidence and knowledge production? The digitization of thousands of films from the former Institute for Scientific Film (IWF) that is currently underway gives an occasion to think about the provenance and reuses of filmic images as well as the ways in which they claim to produce scientific (or in this case, historical) evidence. In the years between 1956 and 1960, the German Social Democrat, historian and filmmaker Friedrich “Fritz” Terveen initiated a film series that used historical found film footage in order to educate university students about contemporary history. The first small series of films was entitledAirship Aviation in Germanywhich consisted of four short films using found footage of zeppelin flights, of which the earliest images stem from around 1904 and the latest from 1937, the moment of the “Hindenburg disaster.” This article explores how Terveen sought to shape the political landscape of history teaching in the new Federal Republic of Germany by first setting up nation-wide visual archives to host historical film documents, and secondly by seeking to improve the political education of a new generation of young Germans with the aid of the moving image.
Altersspezifische Trends des risikoreichen Alkoholkonsums in Deutschland: Parallele oder unterschiedliche Verläufe?
Authors: Kraus Ludwig , Loy Johanna K. , Wilms Nicolas , Starker Anne 
Published: May 2021

Zusammenfassung
Einleitung
Nach der Collectivity-of-Drinking-Cultures-Theorie von Skog finden Veränderungen des Alkoholkonsums in allen Bevölkerungsgruppen und -schichten als parallele Verschiebungen statt. Ziele des vorliegenden Beitrags sind (1) die Darstellung zeitlicher Trends des riskanten Konsums und des episodischen Rauschtrinkens nach Altersgruppen und Geschlecht und (2) die Prüfung, ob die Trends in allen Altersgruppen parallel verlaufen („Kollektivität“) oder zwischen Altersgruppen divergieren („Polarisierung“).

Methoden
Datengrundlage sind 9 Erhebungen des Epidemiologischen Suchtsurveys (ESA) zwischen 1995 und 2018. Als Schwellenwert für riskanten Alkoholkonsum wurde ein täglicher Konsum von mehr als 12 g Reinalkohol bei Frauen beziehungsweise 24 g bei Männern herangezogen. Episodisches Rauschtrinken wurde als Konsum von 5 oder mehr Gläsern Alkohol (ca. 70 g Reinalkohol) an mindestens einem Tag in den letzten 30 Tagen definiert. Lineare Regressionen wurden für die Vorhersage des zeitlichen Effekts auf riskanten Konsum bzw. Rauschkonsum nach Altersgruppen (18–29, 30–39, 40–49 und 50–59 Jahre) und Geschlecht getrennt berechnet und auf Unterschiede geprüft.

Ergebnisse
Die Entwicklungen riskanten Alkoholkonsums nach Altersgruppen verlaufen bei Männern weitgehend parallel, bei Frauen gegenläufig. Die Trends des episodischen Rauschtrinken weisen bei beiden Geschlechtern keine parallele Entwicklung auf: Während in der jüngsten und ältesten Altersgruppe die Prävalenz im Zeitverlauf anstieg, sank sie in den übrigen Altersgruppen.

Diskussion
Vor dem Hintergrund einer generellen Abnahme spricht die Zunahme in den Trends risikoreichen Alkoholkonsums in bestimmten Gruppen für einen Ausbau verhaltenspräventiver Maßnahmen. Zur Fortsetzung der positiven Entwicklung und der Vermeidung einer Trendumkehr sollten zudem auf die Gesamtbevölkerung ausgerichtete Präventionsanstrengungen intensiviert werden, beispielsweise durch Erhöhung der Alkoholsteuer oder Reduktion der Verfügbarkeit von Alkohol.
AI and social theory
Authors: Mökander Jakob , Schroeder Ralph 
Published: May 2021

AbstractIn this paper, we sketch a programme for AI-driven social theory. We begin by defining what we mean by artificial intelligence (AI) in this context. We then lay out our specification for how AI-based models can draw on the growing availability of digital data to help test the validity of different social theories based on their predictive power. In doing so, we use the work of Randall Collins and his state breakdown model to exemplify that, already today, AI-based models can help synthesise knowledge from a variety of sources, reason about the world, and apply what is known across a wide range of problems in a systematic way. However, we also find that AI-driven social theory remains subject to a range of practical, technical, and epistemological limitations. Most critically, existing AI-systems lack three essential capabilities needed to advance social theory in ways that are cumulative, holistic, open-ended, and purposeful. These are (1) semanticisation, i.e., the ability to develop and operationalize verbal concepts to represent machine-manipulable knowledge; (2) transferability, i.e., the ability to transfer what has been learned in one context to another; and (3) generativity, i.e., the ability to independently create and improve on concepts and models. We argue that if the gaps identified here are addressed by further research, there is no reason why, in the future, the most advanced programme in social theory should not be led by AI-driven cumulative advances.
Chronic intestinal inflammation drives colorectal tumor formation triggered by dietary heme iron in vivo
Authors: Seiwert Nina , Adam Janine , Steinberg Pablo , Wirtz Stefan , Schwerdtle Tanja , Adams-Quack Petra , Hövelmeyer Nadine , Kaina Bernd , Foersch Sebastian , Fahrer Jörg 
Published: May 2021

AbstractThe consumption of red meat is associated with an increased risk for colorectal cancer (CRC). Multiple lines of evidence suggest that heme iron as abundant constituent of red meat is responsible for its carcinogenic potential. However, the underlying mechanisms are not fully understood and particularly the role of intestinal inflammation has not been investigated. To address this important issue, we analyzed the impact of heme iron (0.25 µmol/g diet) on the intestinal microbiota, gut inflammation and colorectal tumor formation in mice. An iron-balanced diet with ferric citrate (0.25 µmol/g diet) was used as reference. 16S rRNA sequencing revealed that dietary heme reduced α-diversity and caused a persistent intestinal dysbiosis, with a continuous increase in gram-negative Proteobacteria. This was linked to chronic gut inflammation and hyperproliferation of the intestinal epithelium as attested by mini-endoscopy, histopathology and immunohistochemistry. Dietary heme triggered the infiltration of myeloid cells into colorectal mucosa with an increased level of COX-2 positive cells. Furthermore, flow cytometry-based phenotyping demonstrated an increased number of T cells and B cells in the lamina propria following heme intake, while γδ-T cells were reduced in the intraepithelial compartment. Dietary heme iron catalyzed formation of fecal N-nitroso compounds and was genotoxic in intestinal epithelial cells, yet suppressed intestinal apoptosis as evidenced by confocal microscopy and western blot analysis. Finally, a chemically induced CRC mouse model showed persistent intestinal dysbiosis, chronic gut inflammation and increased colorectal tumorigenesis following heme iron intake. Altogether, this study unveiled intestinal inflammation as important driver in heme iron-associated colorectal carcinogenesis.
Which particles to select, and if yes, how many?
Authors: Schwaferts Christian , Schwaferts Patrick , von der Esch Elisabeth , Elsner Martin , Ivleva Natalia P. 
Published: May 2021

AbstractMicro- and nanoplastic contamination is becoming a growing concern for environmental protection and food safety. Therefore, analytical techniques need to produce reliable quantification to ensure proper risk assessment. Raman microspectroscopy (RM) offers identification of single particles, but to ensure that the results are reliable, a certain number of particles has to be analyzed. For larger MP, all particles on the Raman filter can be detected, errors can be quantified, and the minimal sample size can be calculated easily by random sampling. In contrast, very small particles might not all be detected, demanding a window-based analysis of the filter. A bootstrap method is presented to provide an error quantification with confidence intervals from the available window data. In this context, different window selection schemes are evaluated and there is a clear recommendation to employ random (rather than systematically placed) window locations with many small rather than few larger windows. Ultimately, these results are united in a proposed RM measurement algorithm that computes confidence intervals on-the-fly during the analysis and, by checking whether given precision requirements are already met, automatically stops if an appropriate number of particles are identified, thus improving efficiency.
Carbon nanomaterial hybrids via laser writing for high-performance non-enzymatic electrochemical sensors: a critical review
Authors: Simsek Marcel , Wongkaew Nongnoot 
Published: May 2021

AbstractNon-enzymatic electrochemical sensors possess superior stability and affordability in comparison to natural enzyme-based counterparts. A large variety of nanomaterials have been introduced as enzyme mimicking with appreciable sensitivity and detection limit for various analytes of which glucose and H2O2have been mostly investigated. The nanomaterials made from noble metal, non-noble metal, and metal composites, as well as carbon and their derivatives in various architectures, have been extensively proposed over the past years. Three-dimensional (3D) transducers especially realized from the hybrids of carbon nanomaterials either with metal-based nanocatalysts or heteroatom dopants are favorable owing to low cost, good electrical conductivity, and stability. In this critical review, we evaluate the current strategies to create such nanomaterials to serve as non-enzymatic transducers. Laser writing has emerged as a powerful tool for the next generation of devices owing to their low cost and resultant remarkable performance that are highly attractive to non-enzymatic transducers. So far, only few works have been reported, but in the coming years, more and more research on this topic is foreseeable.Graphical abstract
The potential of training specialist oncology nurses in real-life reporting of adverse drug reactions
Authors: Reumerman M. , Tichelaar J. , van Eekeren R. , van Puijenbroek E. P. , Richir M. C. , van Agtmael M. A. 
Published: May 2021

AbstractSpecialist oncology nurses (SONs) have the potential to play a major role in monitoring and reporting adverse drug reactions (ADRs); and reduce the level of underreporting by current healthcare professionals. The aim of this study was to investigate the long term clinical and educational effects of real-life pharmacovigilance education intervention for SONs on ADR reporting. This prospective cohort study, with a 2-year follow-up, was carried out in the three postgraduate schools in the Netherlands. In one of the schools, the prescribing qualification course was expanded to include a lecture on pharmacovigilance, an ADR reporting assignment, and group discussion of self-reported ADRs (intervention). The clinical value of the intervention was assessed by analyzing the quantity and quality of ADR-reports sent to the Netherlands Pharmacovigilance Center Lareb, up to 2 years after the course and by evaluating the competences regarding pharmacovigilance of SONs annually. Eighty-eight SONs (78% of all SONs with a prescribing qualification in the Netherlands) were included. During the study, 82 ADRs were reported by the intervention group and 0 by the control group. This made the intervention group 105 times more likely to report an ADR after the course than an average nurse in the Netherlands. This is the first study to show a significant and relevant increase in the number of well-documented ADR reports after a single educational intervention. The real-life pharmacovigilance educational intervention also resulted in a long-term increase in pharmacovigilance competence. We recommend implementing real-life, context- and problem-based pharmacovigilance learning assignments in all healthcare curricula.
Contrast-enhanced ultrasound of pediatric lungs
Authors: Rafailidis Vasileios , Andronikou Savvas , Mentzel Hans-Joachim , Piskunowicz Maciej , Squires Judy H. , Barnewolt Carol E. 
Published: May 2021

AbstractIn addition to radiography, ultrasound (US) has long proved to be a valuable imaging modality to evaluate the pediatric lung and pleural cavity. Its many inherent advantages, including real-time performance, high spatial resolution, lack of ionizing radiation and lack of need for sedation make it preferable over other imaging modalities such as CT. Since the introduction of ultrasound contrast agents (UCAs), contrast-enhanced ultrasound (CEUS) has become a valuable complementary US technique, with many well-established uses in adults and evolving uses in children. Lung CEUS applications are still not licensed and are performed off-label, although the added value of CEUS in certain clinical scenarios is increasingly reported. The limited evidence of CEUS in the evaluation of pediatric lungs focuses primarily on community-acquired pneumonia and its complications. In this clinical setting, CEUS is used to confidently and accurately diagnose necrotizing pneumonia and to delineate pleural effusions and empyema. In addition to intravenous use, UCAs can be administered directly into the pleural cavity through chest catheters to improve visualization of loculations within a complex pleural effusion, which might necessitate fibrinolytic therapy. The purpose of this paper is to present the current experience on pediatric lung CEUS and to suggest potential additional uses that can be derived from adult studies.
Contrast-enhanced ultrasound of benign and malignant liver lesions in children
Authors: Fang Cheng , Anupindi Sudha A. , Back Susan J. , Franke Doris , Green Thomas G. , Harkanyi Zoltan , Jüngert Jörg , Kwon Jeannie K. , Paltiel Harriet J. , Squires Judy H. , Zefov Vassil N. , McCarville M. Beth 
Published: May 2021

AbstractContrast-enhanced ultrasound (CEUS) is increasingly being used in children. One of the most common referrals for CEUS performance is characterization of indeterminate focal liver lesions and follow-up of known liver lesions. In this setting, CEUS is performed with intravenous administration of ultrasound contrast agents (UCAs). When injected into a vein, UCA microbubbles remain confined within the vascular network until they dissipate. Therefore, visualization of UCA within the tissues and lesions corresponds to true blood flow. CEUS enables continuous, real-time observation of the enhancement pattern of a focal liver lesion, allowing in most cases for a definite diagnosis and obviating the need for further cross-sectional imaging or other interventional procedures. The recent approval of Lumason (Bracco Diagnostics, Monroe Township, NJ) for pediatric liver CEUS applications has spurred the widespread use of CEUS. In this review article we describe the role of CEUS in pediatric liver applications, focusing on the examination technique and interpretation of main imaging findings of the most commonly encountered benign and malignant focal liver lesions. We also compare the diagnostic performance of CEUS with other imaging modalities for accurate characterization of focal liver lesions.
Der Wearable Kardioverter-Defibrillator als Diagnostikum
Authors: Pulickal Tobyson , Helms Thomas M. , Perings Christian A. 
Published: May 2021

ZusammenfassungEine telemedizinische Versorgung kann neue Einsatzmöglichkeiten bereits etablierter Therapeutika wie einer tragbaren Defibrillator-Weste (WCD) ermöglichen und über ein verbessertes Management von hierüber abgeleiteten Vitaldaten die Versorgungsqualität von chronisch kranken Patienten mit Herzinsuffizienz (HI) erhöhen. Im aktuellen Fallbericht wird der klinische Verlauf eines 71 Jahre alten Patienten beschrieben, der nach einer akuten kardialen Dekompensation und neudiagnostizierter hochgradiger Einschränkung der kardialen Pumpfunktion im Rahmen einer ischämischen Kardiomyopathie leitliniengerecht mit einer WCD bis zur endgültigen Entscheidung über eine ICD-Implantation versorgt wurde. Die durch die WCD gesammelten Vitalwerte wurden über ein Telemedizinzentrum (TMZ) strukturiert ausgewertet und hierbei ein Rezidiv des vorbekannten paroxysmalen Vorhofflimmerns (VHF) entdeckt, was vor einer möglichen Dekompensation durch Anpassung der Medikation und frühzeitiger Initiierung einer Pulmonalvenenisolation (PVI) therapiert werden konnte. Dieser Fall zeigt exemplarisch die Sinnhaftigkeit strukturierter telemedizinischer Intervention auf, die es ermöglicht, etablierte Konzepte der Patientenversorgung sinnvoll zu ergänzen, bestehende Konzepte zu optimieren und die Patientenversorgung signifikant zu verbessern.
Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential
Authors: Ferreira Nelson , Gram Hjalte , Sorrentino Zachary A. , Gregersen Emil , Schmidt Sissel Ida , Reimer Lasse , Betzer Cristine , Perez-Gozalbo Clara , Beltoja Marjo , Nagaraj Madhu , Wang Jie , Nowak Jan S. , Dong Mingdong , Willén Katarina , Cholak Ersoy , Bjerregaard-Andersen Kaare , Mendez Nicolas , Rabadia Prakruti , Shahnawaz Mohammad , Soto Claudio , Otzen Daniel E. , Akbey Ümit , Meyer Morten , Giasson Benoit I. , Romero-Ramos Marina , Jensen Poul Henning 
Published: May 2021

AbstractPathology consisting of intracellular aggregates of alpha-Synuclein (α-Syn) spread through the nervous system in a variety of neurodegenerative disorders including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy. The discovery of structurally distinct α-Syn polymorphs, so-called strains, supports a hypothesis where strain-specific structures are templated into aggregates formed by native α-Syn. These distinct strains are hypothesised to dictate the spreading of pathology in the tissue and the cellular impact of the aggregates, thereby contributing to the variety of clinical phenotypes. Here, we present evidence of a novel α-Syn strain induced by the multiple system atrophy-associated oligodendroglial protein p25α. Using an array of biophysical, biochemical, cellular, and in vivo analyses, we demonstrate that compared to α-Syn alone, a substoichiometric concentration of p25α redirects α-Syn aggregation into a unique α-Syn/p25α strain with a different structure and enhanced in vivo prodegenerative properties. The α-Syn/p25α strain induced larger inclusions in human dopaminergic neurons. In vivo, intramuscular injection of preformed fibrils (PFF) of the α-Syn/p25α strain compared to α-Syn PFF resulted in a shortened life span and a distinct anatomical distribution of inclusion pathology in the brain of a human A53T transgenic (line M83) mouse. Investigation of α-Syn aggregates in brain stem extracts of end-stage mice demonstrated that the more aggressive phenotype of the α-Syn/p25α strain was associated with an increased load of α-Syn aggregates based on a Förster resonance energy transfer immunoassay and a reduced α-Syn aggregate seeding activity based on a protein misfolding cyclic amplification assay. When injected unilaterally into the striata of wild-type mice, the α-Syn/p25α strain resulted in a more-pronounced motoric phenotype than α-Syn PFF and exhibited a “tropism” for nigro-striatal neurons compared to α-Syn PFF. Overall, our data support a hypothesis whereby oligodendroglial p25α is responsible for generating a highly prodegenerative α-Syn strain in multiple system atrophy.