bluuebunny/crossref_metadata_2025_split huggingface dataset:
The utility of plasma circulating cell-free messenger RNA as a biomarker of glioma: a pilot study
Authors: Ita Michael Itak , Wang Jiang Huai , Toulouse André , Lim Chris , Fanning Noel , O’Sullivan Michael , Nolan Yvonne , Kaar George Finbarr , Redmond Henry Paul 
Published: October 2021

Abstract
Background
Research into the potential utility of plasma-derived circulating cell-free nucleic acids as non-invasive adjuncts to radiological imaging have been occasioned by the invasive nature of brain tumour biopsy. The objective of this study was to determine whether significant differences exist in the plasma transcriptomic profile of glioma patients relative to differences in their tumour characteristics, and also whether any observed differences were representative of synchronously obtained glioma samples and TCGA glioma-derived RNA.

Methods
Blood samples were collected from twenty glioma patients prior to tumour resection. Plasma ccfmRNAs and glioma-derived RNA were extracted and profiled.

Results
BCL2L1, GZMB, HLA-A, IRF1, MYD88, TLR2, and TP53 genes were significantly over-expressed in glioma patients (p < 0.001, versus control). GZMB and HLA-A genes were significantly over-expressed in high-grade glioma patients (p < 0.001, versus low-grade glioma patients). Moreover, the fold change of the BCL2L1 gene was observed to be higher in patients with high-grade glioma (p = 0.022, versus low-grade glioma patients). There was positive correlation between the magnitude of fold change of differentially expressed genes in plasma- and glioma-derived RNA (Spearman r = 0.6344, n = 14, p = 0.017), and with the mean FPKM in TCGA glioma-derived RNA samples (Spearman r = 0.4614, n = 19, p < 0.05). There was positive correlation between glioma radiographic tumour burden and the magnitude of fold change of the CSF3 gene (r = 0.9813, n = 20, p < 0.001).

Conclusion
We identified significant differential expression of genes involved in cancer inflammation and immunity crosstalk among patients with different glioma grades, and there was positive correlation between their transcriptomic profile in plasma and tumour samples, and with TCGA glioma-derived RNA.
Fire-fallow agriculture as a sustainable cropping system for maintaining organic carbon in Maré Loyalty Island (New Caledonia, southwest Pacific)
Authors: Leopold Audrey , Drouin Julien , Drohnu Elia , Kaplan Hélène , Wamejonengo Jacques , Bouard Severine 
Published: October 2021

AbstractThe Loyalty Islands are part of the French archipelago of New Caledonia in the Southwest Pacific. In these islands, Gibbsic Ferralsols (Humic) are traditionally used for fire-fallow cultivation (FFC) by the Kanak people, but the planting of perennial orchards has been encouraged over the past two decades. The impacts of this policy on soil organic carbon (SOC) are nevertheless unknown, especially in these clay-free soils in which organic matter is the main contributor to soil fertility. SOC and permanganate oxidizable organic carbon (POXC) were studied in the soils of avocado orchards, FFC, and secondary and native forests. Mean SOC stocks are particularly high, ranging between 71.9 and 194.4 MgC ha−1 in an equivalent soil mass of 2000 Mg ha−1, but they are significantly impacted by land use. Avocado farming reduced SOC stocks by about 30% compared to forest soils, even if fields were established on secondary forests that had already experienced SOC losses. In contrast, FFC did not impact them. The POXC content decreased as the degree of soil anthropization increased; however, it was less sensitive than SOC in highlighting the impacts of land use. SOC storage can be achieved through changes in agricultural practices in avocado farming, with support for farmers in transitioning from family farming to perennial cultivation and the policy management of secondary forests designed to enhance the recovery of native forests.
Osimertinib in poor performance status patients with T790M-positive advanced non-small-cell lung cancer after progression of first- and second-generation EGFR-TKI treatments (NEJ032B)
Authors: Tsubata Yukari , Watanabe Kana , Saito Ryota , Nakamura Atsushi , Yoshioka Hiroshige , Morita Mami , Honda Ryoichi , Kanaji Nobuhiro , Ohizumi Satoshi , Jingu Daisuke , Nakagawa Taku , Nakazawa Kensuke , Mouri Atsuto , Takeuchi Susumu , Furuya Naoki , Akazawa Yuki , Miura Kiyotaka , Ichihara Eiki , Maemondo Makoto , Morita Satoshi , Kobayashi Kunihiko , Isobe Takeshi 
Published: October 2021

Abstract
Background
Osimertinib is effective in patients with T790M mutation-positive advanced non-small-cell lung cancer (NSCLC) resistant to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). However, its effectiveness and safety in patients with poor performance status (PS) are unknown.

Methods
Enrolled patients showed disease progression after treatment with gefitinib, erlotinib, or afatinib; T790M mutation; stage IIIB, IV, or recurrent disease; and PS of 2–4. Osimertinib was orally administered at a dose of 80 mg/day. The primary endpoint of this phase II study (registration, jRCTs061180018) was response rate and the secondary endpoints were progression-free survival (PFS), overall survival (OS), disease control rate, and safety.

Results
Thirty-three patients were enrolled, of which 69.7% and 24.2% had PS of 2 and 3, respectively. One patient was excluded due to protocol violation; in the remaining 32 patients, the response rate was 53.1%; disease control rate was 75.0%; PFS was 5.1 months; and OS was 10.0 months. The most frequent adverse event of grade 3 or higher severity was lymphopenia (12.1%). Interstitial lung disease (ILD) was observed at all grades and at grades 3–5 in 15.2% (5/33) and 6.1% (2/33) of patients, respectively. Treatment-related death due to ILD occurred in one patient. Patients negative for activating EGFR mutations after osimertinib administration had longer median PFS than those positive for these mutations.

Conclusion
Osimertinib was sufficiently effective in EGFR-TKI-resistant, poor PS patients with T790M mutation-positive advanced NSCLC. Plasma EGFR mutation clearance after TKI treatment could predict the response to EGFR-TKIs.
Simulation-based multi-criteria decision making: an interactive method with a case study on infectious disease epidemics
Authors: Dunke Fabian , Nickel Stefan 
Published: October 2021

AbstractWhenever a system needs to be operated by a central decision making authority in the presence of two or more conflicting goals, methods from multi-criteria decision making can help to resolve the trade-offs between these goals. In this work, we devise an interactive simulation-based methodology for planning and deciding in complex dynamic systems subject to multiple objectives and parameter uncertainty. The outline intermittently employs simulation models and global sensitivity analysis methods in order to facilitate the acquisition of system-related knowledge throughout the iterations. Moreover, the decision maker participates in the decision making process by interactively adjusting control variables and system parameters according to a guiding analysis question posed for each iteration. As a result, the overall decision making process is backed up by sensitivity analysis results providing increased confidence in terms of reliability of considered decision alternatives. Using the efficiency concept of Pareto optimality and the sensitivity analysis method of Sobol’ sensitivity indices, the methodology is then instantiated in a case study on planning and deciding in an infectious disease epidemic situation similar to the 2020 coronavirus pandemic. Results show that the presented simulation-based methodology is capable of successfully addressing issues such as system dynamics, parameter uncertainty, and multi-criteria decision making. Hence, it represents a viable tool for supporting decision makers in situations characterized by time dynamics, uncertainty, and multiple objectives.
The Importance of Intact Senses in Mating and Social Assessments Made by Deaf Individuals
Authors: Oleszkiewicz Anna , Idziak Paulina , Rokosz Marta 
Published: October 2021

AbstractSocial perception is a multimodal process involving vision and audition as central input sources for human social cognitive processes. However, it remains unclear how profoundly deaf people assess others in the context of mating and social interaction. The current study explored the relative importance of different sensory modalities (vision, smell, and touch) in assessments of opposite- and same-sex strangers. We focused on potential sensory compensation processes in mate selection (i.e., increased importance of the intact senses in forming impressions of an opposite-sex stranger as a potential partner). A total of 74 deaf individuals and 100 normally hearing controls were included in the study sample. We found diminished importance of vision and smell in deaf participants compared with controls for opposite- and same-sex strangers, and increased importance of touch for the assessment of same-sex strangers. The results suggested that deaf people rely less on visual and olfactory cues in mating and social assessments, highlighting a possible role of sign language in shaping interpersonal tactile experience in non-romantic relationships.
Scattering efficiencies measurements of soft protons at grazing incidence from an Athena Silicon Pore Optics sample
Authors: Amato Roberta , Diebold Sebastian , Guzman Alejandro , Perinati Emanuele , Tenzer Chris , Santangelo Andrea , Mineo Teresa 
Published: October 2021

AbstractSoft protons are a potential threat for X-ray missions using grazing incidence optics, as once focused onto the detectors they can contribute to increase the background and possibly induce radiation damage as well. The assessment of these undesired effects is especially relevant for the future ESA X-ray mission Athena, due to its large collecting area. To prevent degradation of the instrumental performance, which ultimately could compromise some of the scientific goals of the mission, the adoption of ad-hoc magnetic diverters is envisaged. Dedicated laboratory measurements are fundamental to understand the mechanisms of proton forward scattering, validate the application of the existing physical models to the Athena case and support the design of the diverters. In this paper we report on scattering efficiency measurements of soft protons impinging at grazing incidence onto a Silicon Pore Optics sample, conducted in the framework of the EXACRAD project. Measurements were taken at two different energies, $\sim $
∼
470 keV and $\sim $
∼
170 keV, and at four different scattering angles between 0.6∘ and 1.2∘. The results are generally consistent with previous measurements conducted on eROSITA mirror samples, and as expected the peak of the scattering efficiency is found around the angle of specular reflection.
Review of applications and challenges of quantitative systems pharmacology modeling and machine learning for heart failure
Authors: Cheng Limei , Qiu Yuchi , Schmidt Brian J. , Wei Guo-Wei 
Published: October 2021

AbstractQuantitative systems pharmacology (QSP) is an important approach in pharmaceutical research and development that facilitates in silico generation of quantitative mechanistic hypotheses and enables in silico trials. As demonstrated by applications from numerous industry groups and interest from regulatory authorities, QSP is becoming an increasingly critical component in clinical drug development. With rapidly evolving computational tools and methods, QSP modeling has achieved important progress in pharmaceutical research and development, including for heart failure (HF). However, various challenges exist in the QSP modeling and clinical characterization of HF. Machine/deep learning (ML/DL) methods have had success in a wide variety of fields and disciplines. They provide data-driven approaches in HF diagnosis and modeling, and offer a novel strategy to inform QSP model development and calibration. The combination of ML/DL and QSP modeling becomes an emergent direction in the understanding of HF and clinical development new therapies. In this work, we review the current status and achievement in QSP and ML/DL for HF, and discuss remaining challenges and future perspectives in the field.
Success factors of initial coin offerings
Authors: Belitski Maksim , Boreiko Dmitri 
Published: October 2021

AbstractThis study furthers recent research on Initial Coin Offerings (ICO) in understanding the set of characteristics that drive ICO performance and reduce information asymmetry. Using data on 166 ICOs and more than 300,000 contribution addresses that sent funds to ICOs in Bitcoins or in Ether between 2013 and 2017, we examined the effect of ICO characteristics on ICO performance. We found that three boundary conditions predict ICO fundraising amount, number of investors, hard cap achievement and token ranking. These are registering ICO and publishing project’s code on GitHub, obtaining VC or Business angel financing before the campaign or during presale, and finally, publishing the whitepaper before the campaign’s start. Other factors such as serial investors, presale of tokens, bonus sales and funders' ownership share explain ICO performance. We offer implications for ICO investors and policymakers.
Kasteleyn Theorem, Geometric Signatures and KP-II Divisors on Planar Bipartite Networks in the Disk
Authors: Abenda Simonetta 
Published: October 2021

AbstractMaximal minors of Kasteleyn sign matrices on planar bipartite graphs in the disk count dimer configurations with prescribed boundary conditions, and the weighted version of such matrices provides a natural parametrization of the totally non–negative part of real Grassmannians (Postnikov et al. J. Algebr. Combin. 30(2), 173–191, 2009; Lam J. Lond. Math. Soc. (2) 92(3), 633–656, 2015; Lam 2016; Speyer 2016; Affolter et al. 2019). In this paper we provide a geometric interpretation of such variant of Kasteleyn theorem: a signature is Kasteleyn if and only if it is geometric in the sense of Abenda and Grinevich (2019). We apply this geometric characterization to explicitly solve the associated system of relations and provide a new proof that the parametrization of positroid cells induced by Kasteleyn weighted matrices coincides with that of Postnikov boundary measurement map. Finally we use Kasteleyn system of relations to associate algebraic geometric data to KP multi-soliton solutions. Indeed the KP wave function solves such system of relations at the nodes of the spectral curve if the dual graph of the latter represents the soliton data. Therefore the construction of the divisor is automatically invariant, and finally it coincides with that in Abenda and Grinevich (Sel. Math. New Ser. 25(3), 43, 2019; Abenda and Grinevich 2020) for the present class of graphs.
How to compute invariant manifolds and their reduced dynamics in high-dimensional finite element models
Authors: Jain Shobhit , Haller George 
Published: October 2021

AbstractInvariant manifolds are important constructs for the quantitative and qualitative understanding of nonlinear phenomena in dynamical systems. In nonlinear damped mechanical systems, for instance, spectral submanifolds have emerged as useful tools for the computation of forced response curves, backbone curves, detached resonance curves (isolas) via exact reduced-order models. For conservative nonlinear mechanical systems, Lyapunov subcenter manifolds and their reduced dynamics provide a way to identify nonlinear amplitude–frequency relationships in the form of conservative backbone curves. Despite these powerful predictions offered by invariant manifolds, their use has largely been limited to low-dimensional academic examples. This is because several challenges render their computation unfeasible for realistic engineering structures described by finite element models. In this work, we address these computational challenges and develop methods for computing invariant manifolds and their reduced dynamics in very high-dimensional nonlinear systems arising from spatial discretization of the governing partial differential equations. We illustrate our computational algorithms on finite element models of mechanical structures that range from a simple beam containing tens of degrees of freedom to an aircraft wing containing more than a hundred–thousand degrees of freedom.
Computational Social Science for Nonprofit Studies: Developing a Toolbox and Knowledge Base for the Field
Authors: Ma Ji , Ebeid Islam Akef , de Wit Arjen , Xu Meiying , Yang Yongzheng , Bekkers René , Wiepking Pamala 
Published: October 2021

AbstractHow can computational social science (CSS) methods be applied in nonprofit and philanthropic studies? This paper summarizes and explains a range of relevant CSS methods from a research design perspective and highlights key applications in our field. We define CSS as a set of computationally intensive empirical methods for data management, concept representation, data analysis, and visualization. What makes the computational methods “social” is that the purpose of using these methods is to serve quantitative, qualitative, and mixed-methods social science research, such that theorization can have a solid ground. We illustrate the promise of CSS in our field by using it to construct the largest and most comprehensive database of scholarly references in our field, the Knowledge Infrastructure of Nonprofit and Philanthropic Studies (KINPS). Furthermore, we show that through the application of CSS in constructing and analyzing KINPS, we can better understand and facilitate the intellectual growth of our field. We conclude the article with cautions for using CSS and suggestions for future studies implementing CSS and KINPS.
Call to action: cardiologists should promote influenza vaccination
Authors: Habib G. L. , Yousuf H. , Narula J. , Hofstra L. 
Published: October 2021

AbstractThe COVID-19 pandemic has spurred clinical and scientific interest in the cardiology community because of the significantly enhanced vulnerability of patients with underlying cardiac diseases. COVID-19 vaccination is therefore of vital importance to the patients we see in our clinics and hospitals every day and should be promoted by the medical community, especially cardiologists. In view of vaccine-preventable diseases, the association between influenza and cardiovascular complications has been widely investigated. Several studies have found a substantially elevated risk of hospital admission for acute myocardial infarction in the first 7 days after laboratory-confirmed influenza, with incidence ratios ranging from 6.05–8.89. The effectiveness of the influenza vaccine to protect against acute myocardial infarction is about 29%. This effectiveness is comparable to or even better than that of existing secondary preventive therapies, such as statins (prevention rate approximately 36%), antihypertensives (prevention rate approximately 15–18%), and smoking cessation (prevention rate approximately 26%). As the influenza season is rapidly approaching, this Point of View article serves as a call to action: Cardiologists should promote influenza vaccination and actively advice their patients to get the seasonal influenza vaccination.
Financialisation reinforced: the dual legacy of the covid pandemic
Authors: Lysandrou Photis , Ranjbaran Taimaz 
Published: October 2021

AbstractThis paper examines the impact of the covid pandemic on the financialisation process, here viewed as the growing domination of the world’s bond and equity markets over the world’s product markets. Two major arguments are advanced. The first is that the pandemic has reinforced the functionality of financial market scale, which is that its continuing growth signifies nothing other than that government and corporate organisations are colonising the future to cope with the rising financial pressures of the present. The second argument is that the pandemic has also accentuated one of the more notable dysfunctional aspects of the continuing growth of financial market scale, which is its enforcement of a core-periphery divide between the advanced and emerging market economies that occupy the global financial system. The paper concludes with some policy implications of the analysis that includes the call for a global wealth tax.
Advocating for Preservation
Authors: Banks Kimball M. , Snortland J. Signe 
Published: October 2021

AbstractOver the past few years our body politic has become increasingly polarized: Republicans versus Democrats, conservatives versus liberals. That polarization filters down to governmental actions, policies, and decisions, evidenced in disagreements over regulation versus deregulation and fossil fuels versus renewable energy. Such polarization—whether legislative, administrative, or judicial and whether at the federal, state, or tribal level—can and does impact the management of our archaeological resources and the way cultural resource management is practiced in the United States. Given that most archaeologists in the United States are employed in cultural resource management, these actions affect their employment. Consequently, it is more critical than ever that archaeologists become cultural resource management and historic preservation advocates. This article discusses the whys and hows of preservation advocacy. Active, science-based advocacy by preservationists can engage governmental decision-makers to give due consideration to cultural resources and their management when making decisions or drafting and voting on legislation. Although the discussion focuses on advocacy at the federal level, the observations and suggestions are applicable at the state and local level.
India and overseas Indians in Ceylon and Burma, 1946–1965: Experiments in post-imperial sovereignty
Authors: Khan Raphaëlle , Sherman Taylor C. 
Published: October 2021

AbstractDespite the existence of a large Indian diaspora, there has been relatively little scholarly attention paid to India's relations with overseas Indians after its independence in 1947. The common narrative is that India abruptly cut ties with overseas Indians at independence, as it adhered to territorially based understandings of sovereignty and citizenship. Re-examining India's relations with Indian communities in Ceylon and Burma between the 1940s and the 1960s, this article demonstrates that, despite its rhetoric, independent India did not renounce responsibility for its diaspora. Instead, because of pre-existing social connections that spanned the former British empire, the Government of India faced regular demands to assist overseas Indians, and it responded on several fronts. To understand this continued engagement with overseas Indians, this article introduces the idea of ‘post-imperial sovereignty'. This type of sovereignty was layered, as imperial sovereignty had been, but was also concerned with advancing norms designed to protect minority communities across the world. India’s strategy to argue for these norms was simultaneously multilateral, regional, and bilateral. It sought to use the United Nations, the Commonwealth, and the 1947 Asian Relations Conference to secure rights for overseas Indians. As those attempts failed, India negotiated claims for citizenship with governments in Burma and Ceylon, and shaped the institutions and language through which Indians voiced demands for their rights in these countries. Indian expressions of sovereignty beyond the space of the nation-state, therefore, impacted on practices of citizenship, even during the process of de-recognition in Asia.