bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smart workplace solutions – can they deliver the offices that employees have been waiting for?
Authors: Remes Laura , Dooley Kenneth , Ketomäki Jaakko , Ihasalo Heikki 
Published: September 2021

PurposeUser-centred intelligent buildings (IBs) should respond to users’ needs holistically and the demand for end user applications is steadily growing. The purpose of this study is to answer: What are end user applications, what should they be called, and what are their key features?Design/methodology/approachThis is a mixed-method study. The authors have used different data sources, such as online research and interviews. In data processing, the authors have used word counting and Latent Dirichlet Allocation topic modeling.FindingsThese end user applications can provide the missing user-centered elements of IBs. The authors have found that “smart workplace solution” (SWS) is the best term to describe these applications, and they also describe the key features, which include booking, showing free spaces, occupancy tracking, wayfinding and searching.Research limitations/implicationsAs the end user applications are constantly and rapidly evolving, the latest evolving of such applications might not be covered. Furthermore, the authors have relied on companies’ information as given.Originality/valueIBs have emerged over 20 years ago, and these are the first solutions that can be considered truly user-centered.
Strength and microstructure behaviour of high calcium fly ash based sustainable geo polymer concrete
Authors: Prasad B. Vijaya , Daniel Arumairaj Paul , N. Anand , Yadav Siva Kumar 
Published: September 2021

Purpose
Concrete is a building material widely used for the infrastructural development. Cement is the binding material used for the development of concrete. It is the primary cause of CO2 emission globally. The purpose of this study is to develop sustainable concrete material to satisfy the present need of construction sector. Geopolymer concrete (GPC) is a sustainable concrete developed without the use of cement. Therefore, investigations are being conducted to replace the cement by 100% with high calcium fly ash (FA) as binding material.

Design/methodology/approach
High calcium FA is used as cementitious binder, sodium hydroxide (NaOH) and sodium silicates (Na2SiO3) are used as alkaline liquids for developing the GPC. Mix proportions with different NaOH molarities of 4, 6, 8 and 10 M are considered to attain the appropriate mix. The method of curing adopted is ambient and oven curing. Workability, compressive strength and microstructure characteristics of GPC are analysed and presented.

Findings
An increase of NaOH in the mix decreases the workability. Compressive strength of 29 MPa is obtained for Mix-I with 8 M under ambient curing. A polynomial relationship is obtained to predict the compressive strength of GPC. Scanning electron microscope analysis is used to confirm the geo-polymerisation process in the microstructure of concrete.

Originality/value
This research work focuses on finding some alternative cementitious material for concrete that can replace ordinary portland cement (OPC) to overcome the CO2 emission owing to the utilisation of cement in the construction industry. An attempt has been made to use the waste material (high calcium FA) from thermal power plant for the production of GPC. GPC concrete is the novel building material and alternative to conventional concrete. It is the ecofriendly product contributing towards the improvement of the circular economy in the construction industry. There are several factors that affect the property of GPC such as type of binder material, molarity of activator solution and curing condition. The novelty of this work lies in the approach of using locally available high calcium FA along with manufactured sand for the development of GPC. As this approach is rarely investigated, to prove the attainment of compressive strength of GPC with high calcium FA, an attempt has been made during the present investigation. Other influencing parameter which affects the strength gain has also been analysed in this paper.
Interactions between silicon and alkaloid defences in endophyte‐infected grasses and the consequences for a folivore
Authors: Cibils‐Stewart Ximena , Mace Wade J. , Popay Alison J. , Lattanzi Fernando A. , Hartley Susan (Sue) E. , Hall Casey R. , Powell Jeff R. , Johnson Scott N. 
Published: September 2021

AbstractGrasses have developed a wide range of morphological and physiological mechanisms to resist herbivory. For instance, they accumulate silicon (Si) in tissue, as physical defence, and associate symbiotically with foliarEpichloë‐endophytes that provide chemical defence via antiherbivore alkaloids. Recent evidence showed that someEpichloë‐endophytes increase foliar Si in forage grasses; however, whether this impacts insect herbivores is unknown. Furthermore, while Si is primarily a physical defence, it also affects production of plant defensive secondary metabolites; Si supply might therefore affectEpichloë‐alkaloids, although this remains untested.We grew endophyte‐free (Nil) andEpichloë‐infected tall fescue and perennial ryegrass in a factorial combination with or without Si supplementation, in the absence or presence ofHelicoverpa armigera.Epichloë‐endophyte strains were AR584 for tall fescue, and AR37, AR1 or Wild‐type (WT) for perennial ryegrass. We assessed how Si supply andEpichloë‐endophytes in interaction with herbivory affected foliar Si and mutualist‐derived alkaloid concentrations. Subsequently, their effects onH. armigerarelative growth rates (RGRs) were evaluated.Endophytes generally increased Si concentrations in Si‐supplied plants. In tall fescue AR584 and perennial ryegrass AR37, endophytes increased constitutive (herbivore‐free) and induced (herbivore‐inoculated) Si concentrations by at least 25%; in contrast, in perennial ryegrass, the AR1 endophyte only increased constitutive levels. Si supply did not affect alkaloids produced by AR584 or AR1/WT endophytes; however, in the presence of herbivory, Si supply decreased the induction of alkaloids produced by AR37 endophytes by 33%. For tall fescue, Si supply reducedH. armigeraRGR by at least 76%, regardless of endophytic status, whereas, endophyte‐alkaloids played a secondary role only reducing herbivore growth in the absence of Si supply. Conversely, in perennial ryegrass, both Si and endophyte‐alkaloids (regardless of Si supply) reduced herbivore RGR although not synergised.Novel interactions between constitutive and induced Si‐ and alkaloid‐based antiherbivore defences in grasses were observed. Overall, Si had a greater effect on the folivore than endophytes in both grasses. Endophyte defences contributed more to herbivore resistance in perennial ryegrass than tall fescue. We demonstrate that Si and endophytes were not antagonistic and highlight that the protective nature of their interaction varies with the grass‐endophyte species tested.A freePlain Language Summarycan be found within the Supporting Information of this article.
‘Look on my works ye mighty…’: Iconoclasm, education and the fate of statues
Authors: Davis Robert A 
Published: September 2021

AbstractIn pursuit of an alternative perspective on the so-called ‘statues controversy’, this essay brings recent interpretations of the enduring ‘power’, ‘gaze’ and ‘magic’ of statues into alignment with critical histories of iconoclasm, sacred and secular, and New Materialist accounts of our multiple entanglements with the object histories of inherited monuments. Opening with a close reading of Percy Bysshe Shelley's renowned 1818 sonnet, ‘Ozymandias’, the essay applies the resultant theoretical synthesis to argue for the general restraint of popular iconoclastic and demolitionary acts and largely to caution against the mimetic violence of statue removal in favour of fresh, educative and iconotropic ways of ‘making legible’, and ‘re-reading’, statues, pedestals, inscriptions and their diverse contexts past and present.
Fasting plasma glucose, diagnosis of gestational diabetes and the risk of large for gestational age: a regression discontinuity analysis of routine data
Authors: Tennant PWG , Doxford‐Hook E , Flynn L , Kershaw K , Goddard J , Stacey T 
Published: September 2021

ObjectiveTo estimate the causal effects of fasting plasma glucose (FPG) and diagnosis of gestational diabetes (GDM) on birthweight and the risks of large for gestational age (LGA).DesignRegression discontinuity analysis of routine data.SettingTwo district general hospitals in West Yorkshire, UK.PopulationA cohort of 7062 women with singleton pregnancies who were screened for GDM and gave birth to a baby at ≥24 weeks of gestation in 2017–2019, inclusive.MethodsThe causal effects of FPG and GDM diagnosis were estimated using the two‐stage least‐squares approach, around the diagnostic threshold of FPG ≥ 5.6 mmol/l recommended by the UK’s National Institute for Health and Care Excellent (NICE), controlling for ethnicity, maternal age, parity, height and weight.Main outcome measuresBirthweight (standardised for sex and gestational age) and large for gestational age (standardised as birthweight above the 90th centile).ResultsFor each 1 mmol/l increase in FPG the observed birthweight increased by Z‐score = 0.48 standard deviations (95% CI 0.39 to 0.57) and the odds of LGA increased by OR = 2.61 (95% CI 1.86 to 3.66). Conversely, GDM diagnosis reduced the observed birthweight by Z = −0.61 (95% CI −0.94 to −0.29) and lowered the odds of LGA by OR = 0.33 (95% CI 0.15 to 0.74). Similar, but less certain, patterns were observed for caesarean section, shoulder dystocia and perinatal death.ConclusionsThe relationship between FPG and LGA is potent but is dramatically reduced by GDM diagnosis (and all the consequences thereof). Women with mild hyperglycaemia (with an FPG of 5.1–5.5 mmol/l) who fall below the current NICE threshold for GDM diagnosis have the highest risks of adverse outcomes, suggesting a need to reconsider their current care.Tweetable abstractRegression discontinuity analysis shows that untreated mild hyperglycaemia increases the odds of large for gestational age, but that a diagnosis of gestational #diabetes lowers the odds by three times.
The Role of Disclosure and Information Intermediaries in an Unregulated Capital Market: Evidence from Initial Coin Offerings
Authors: BOURVEAU THOMAS , DE GEORGE EMMANUEL T. , ELLAHIE ATIF , MACCIOCCHI DANIELE 
Published: September 2021

ABSTRACTUsing an international sample of 2,113 initial coin offerings (ICOs), we explore the role of disclosure and information intermediaries in the unregulated crypto‐tokens market. First, we document substantial cross‐sectional variation in the voluntary disclosure practices of ventures seeking to raise capital through ICOs, such as the extent of information released in a prospectus‐type document called a white paper; releasing the technical source code; and communicating through social media platforms. Second, we find that, even with limited disclosure verifiability, ventures with higher levels of disclosure have a greater ability to raise capital. Finally, we find that this association is stronger in the presence of mechanisms that lend credibility to ventures’ voluntary disclosures, such as internal governance practices or external scrutiny from information intermediaries. Overall, our results suggest that voluntary disclosure and information intermediaries facilitate the functioning of ICOs as an alternative capital market.
Cost effectiveness of dietary interventions for individuals with mental disorders: A scoping review of experimental studies
Authors: Burrows Tracy , Teasdale Scott , Rocks Tetyana , Whatnall Megan , Schindlmayr Julia , Plain Janice , Roberton Michelle , Latimer Georgina , Harris Deanne , Forsyth Adrienne 
Published: September 2021

AbstractAimThis scoping review aimed to explore the extent of the evidence of experimental studies evaluating the cost effectiveness of dietary interventions in individuals with mental disorders.MethodsFive databases (CINAHL, EMBASE, MEDLINE, PsycINFO and Scopus) were searched to October 2020 for cost‐analysis studies of interventions aiming to improve dietary intake in people with mental disorders. No restriction was placed on participant age, mental disorder type or intervention design. Results are presented narratively.ResultsOf 2753 articles identified, 13 articles reporting on eight studies were included. Studies were RCTs (n = 5), cluster RCT (n = 1), cluster preference RCT (n = 1), and pre‐post test (n = 1). Seven studies were in community settings (eg, outpatient clinics), and one study in the community housing setting. All studies were in adults, seven included male and female participants, and one included only females. Defined mental disorder diagnoses included serious/severe mental disorders (n = 3), major depression (n = 2), schizophrenia, schizoaffective disorder or first‐episode psychosis (n = 1), any mental disorder (n = 1), and bulimia nervosa (n = 1). Five interventions were multi‐behaviour, two were diet only and one was eating disorder treatment. Cost analyses included cost‐utility (n = 3), cost‐effectiveness (n = 1), cost‐utility and cost‐effectiveness (n = 3), and a costing study (n = 1). Two studies (25%) reported positive results in favour of cost effectiveness, and four studies reported a mix of positive and neutral results.ConclusionsThere is limited evidence evaluating the cost effectiveness of dietary interventions in individuals with mental disorders. Additional studies in various settings are needed to confirm cost effectiveness of different interventions.
Concurrent use of anlotinib overcomes acquired resistance to EGFR‐TKI in patients with advanced EGFR‐mutant non‐small cell lung cancer
Authors: Zhang Chen , Cao Honggang , Cui Yanan , Jin Shidai , Gao Wen , Huang Chenjun , Guo Renhua 
Published: September 2021

AbstractBackgroundAcquired resistance development is a major challenge in the epidermal growth factor receptor‐tyrosine kinase inhibitor (EGFR–TKI) treatment of non–small cell lung cancer (NSCLC). Here, we investigated the potential effects of the concurrent use of anlotinib and EGFR‐TKI to overcome acquired resistance.MethodsWe conducted a preclinical study to evaluate the antitumor effects of gefitinib + anlotinib in gefitinib‐resistant lung adenocarcinoma models in vitro and in vivo. We then investigated the treatment effect of EGFR–TKI + anlotinib therapy in 24 advanced EGFR‐mutant NSCLC patients after EGFR‐TKI acquired resistance between January 2018 and August 2020.ResultsAnlotinib reversed gefitinib resistance in gefitinib‐resistant lung adenocarcinoma models by enhancing the antiproliferative and proapoptotic effects of gefitinib. The gefitinib + anlotinib treatment exerted a synergistic antitumor effect by downregulating the activation of VEGFR2 and downstream effectors, Akt and ERK. The EGFR–TKI + anlotinib therapy exhibited an objective response rate of 20.8% and a disease control rate of 95.8%. Median progression‐free survival (PFS) was 11.53 ± 2.41 months, but median overall survival was not reached. The median PFS was longer in patients experiencing gradual progression (13.30 ± 1.69 months) than in patients with dramatic progression (6.80 ± 1.75 months, p = 0.017). One grade 3 adverse event was noted (diarrhea, n = 2, 8.3%), and grade 4 or 5 adverse events were absent.ConclusionsEGFR–TKI combined with anlotinib demonstrated powerful antitumor activity in vitro and in vivo. Concurrent use of anlotinib overcomes acquired resistance to EGFR‐TKI in advanced EGFR‐mutant NSCLC patients.
Accounting as a Normalizing Tool for Transitional Dirtiness: The Case of theUS Adult‐UseCannabis Industry*
Authors: Romi Andrea M. , Carrasco Heather , Camors Casey A. , Masselli John J. 
Published: September 2021

ABSTRACTWhile prior accounting research documents normalizing strategies within the accounting profession and in instances of accounting adoption, the potential of accounting itself as a strategic tool toward normalizing that which is considered socially abnormal (i.e., dirty) remains an important and unexamined area of inquiry. In this study, we conduct in‐depth interviews to examine the role accounting plays in the development of the US cannabis industry (CI) as it transitions from the illicit market in which formal accounting was systematically avoided to a state‐legal market in which participants are subject to conventional business processes. Facing impediments to traditional operating practices and pressures to increase normative conformity for industry survival, cannabis operators (COs) incorporated the use of accounting in three normalizing strategies (creative concession, collaborative facilitation, and experimentation), seemingly influenced by the incongruencies between prior illicit‐market culture and experiences and the state‐legal operating environment. In response to what operators perceived to be coercive regulation, they employed creative concession strategies, including influencing, bargaining, challenging, escaping, and cessation tactics. However, in response to pressures to adopt more commonly accepted forms of accounting, COs instead deployed two different strategies, one focused on acquiescence to normalizing pressures when doing so facilitated essential relationship building (i.e., collaborative facilitation strategies), and one deployed as strategic experimentation, working to normalize industry activities in areas of perceived threats to industry acceptance and continuity. Given CO accounting naiveté, its usefulness was often introduced by peripheral industry parties attempting to normalize their own participation with the CI. Notably, we also find that normalizing pressures occasionally resulted in unintended consequences, including reversion to the illicit market and forgoing normalizing strategies in favor of retaining some level of dirtiness to fend off pending competition, both of which threaten to reemphasize the industry's dirtiness. Our study, therefore, points to accounting itself as a central mechanism in the complex, multidirectional strategy to normalize transitional dirtiness.
An altered sputum macrophage transcriptome contributes to the neutrophilic asthma endotype
Authors: Fricker Michael , Qin Ling , Sánchez‐Ovando Stephany , Simpson Jodie L. , Baines Katherine J. , Riveros Carlos , Scott Hayley A. , Wood Lisa G. , Wark Peter AB. , Kermani Nazanin Z. , Chung Kian Fan , Gibson Peter G. 
Published: September 2021

AbstractBackgroundNeutrophilic asthma (NA) is a clinically important asthma phenotype, the cellular and molecular basis of which is not completely understood. Airway macrophages are long‐lived immune cells that exert important homeostatic and inflammatory functions which are dysregulated in asthma. Unique transcriptomic programmes reflect varied macrophage phenotypes in vitro. We aimed to determine whether airway macrophages are transcriptomically altered in NA.MethodsWe performed RNASeq analysis on flow cytometry‐isolated sputum macrophages comparing NA (n = 7) and non‐neutrophilic asthma (NNA, n = 13). qPCR validation of RNASeq results was performed (NA n = 13, NNA n = 23). Pathway analysis (PANTHER, STRING) of differentially expressed genes (DEGs) was performed. Gene set variation analysis (GSVA) was used to test for enrichment of NA macrophage transcriptomic signatures in whole sputum microarray (cohort 1 ‐ controls n = 16, NA n = 29, NNA n = 37; cohort 2 U‐BIOPRED ‐ controls n = 16, NA n = 47, NNA n = 57).ResultsFlow cytometry‐sorting significantly enriched sputum macrophages (99.4% post‐sort, 44.9% pre‐sort, p < .05). RNASeq analysis confirmed macrophage purity and identified DEGs in NA macrophages. Selected DEGs (SLAMF7, DYSF, GPR183, CSF3, PI3, CCR7, all p < .05 NA vs. NNA) were confirmed by qPCR. Pathway analysis of NA macrophage DEGs was consistent with responses to bacteria, contribution to neutrophil recruitment and increased expression of phagocytosis and efferocytosis factors. GSVA demonstrated neutrophilic macrophage gene signatures were significantly enriched in whole sputum microarray in NA vs. NNA and controls in both cohorts.ConclusionsWe demonstrate a pathophysiologically relevant sputum macrophage transcriptomic programme in NA. The finding that there is transcriptional activation of inflammatory programmes in cell types other than neutrophils supports the concept of NA as a specific endotype.
Development of a multivariable prediction model for congenital unilateral absence of the vas deferens in male partners of infertile couples
Authors: Brusq Clara , Mieusset Roger , Hamdi Safouane M. 
Published: September 2021

AbstractBackgroundCongenital unilateral absence of vas deferens has been diagnosed in fertile and normozoospermic males and is associated with the risk of unilateral renal absence or cystic fibrosis transmembrane conductance regulator mutations; but no prediction model currently exists to diagnose this condition.ObjectivesThe study aims to identify clinical and biological variables that may have a predictive value for the diagnosis of congenital unilateral absence of vas deferens in male partners of infertile couplesMaterials and methodsWe designed a retrospective, cross‐sectional, case‐control study on electronic health records of a single tertiary‐care andrological centre collected between 1998 and 2018. We included all subjects diagnosed with congenital unilateral absence of vas deferens using combined scrotal and transrectal ultrasounds. Controls were confirmed free of congenital unilateral absence of vas deferens by the same way. Both groups received standardised exploration procedures. Multivariable logistic regression model was built in a backward stepwise manner. Model performance and calibration were assessed. The study is reported according to TRIPOD statement.ResultsWe included 69 congenital unilateral absence of vas deferens cases and 78 controls. Cases had a lower semen volume than controls. The congenital unilateral absence of vas deferens risk was associated with history of cryptorchidism and both levels of semen fructose and α‐glucosidase. These predictors were confirmed by a random forest algorithm. The area under the curve was 0.886 (95% interval: 0.81–0.92). Calibration was performed with the Hosmer‐Lemeshow test (p = 0.88).Discussion and conclusionHistory of cryptorchidism, semen fructose and α‐glucosidase were identified as relevant and independent predictors for the diagnosis of congenital unilateral absence of vas deferens. The model enables to identify male patients with a high risk of congenital unilateral absence of vas deferens to whom a transrectal ultrasounds would be proposed to confirm the diagnosis, whatever their semen parameters. It will also help to address the risks of unilateral renal absence and of cystic fibrosis transmembrane conductance regulator mutations carrying during the management of infertile couples.