bluuebunny/crossref_metadata_2025_split huggingface dataset:
Setting a Course for Preventing Hepatitis E in Low and Lower-Middle-Income Countries: A Systematic Review of Burden and Risk Factors
Authors: Koyuncu Aybüke , Mapemba Daniel , Ciglenecki Iza , Gurley Emily S , Azman Andrew S 
Published: April 2021

Abstract

Background
Hepatitis E virus (HEV) is responsible for outbreaks of acute jaundice in Africa and Asia, many of which occur among displaced people or in crisis settings. Although an efficacious vaccine for HEV has been developed, we lack key epidemiologic data needed to understand how best to use the vaccine for hepatitis E control in endemic countries.

Methods
We conducted a systematic review of articles published on hepatitis E in low-income and lower-middle-income countries in Africa and Asia. We searched PubMed, Scopus, and Embase databases to identify articles with data on anti-HEV immunoglobulin (Ig)G seroprevalence, outbreaks of HEV, or risk factors for HEV infection, disease, or death, and all relevant data were extracted. Using these data we describe the evidence around temporal and geographical distribution of HEV transmission and burden. We estimated pooled age-specific seroprevalence and assessed the consistency in risk factor estimates.

Results
We extracted data from 148 studies. Studies assessing anti-HEV IgG antibodies used 18 different commercial assays. Most cases of hepatitis E during outbreaks were not confirmed. Risk factor data suggested an increased likelihood of current or recent HEV infection and disease associated with fecal-oral transmission of HEV, as well as exposures to blood and animals.

Conclusions
Heterogeneity in diagnostic assays used and exposure and outcome assessment methods hinder public health efforts to quantify burden of disease and evaluate interventions over time and space. Prevention tools such as vaccines are available, but they require a unified global strategy for hepatitis E control to justify widespread use.
Community Antibiotic Use at the Population Level During the SARS-CoV-2 Pandemic in British Columbia, Canada
Authors: Mamun Abdullah A , Saatchi Ariana , Xie Max , Lishman Hannah , Blondel-Hill Edith , Marra Fawziah , Patrick David M 
Published: April 2021

Abstract

Background
The objective of this study was to examine the aggregate rates of antibiotic use at the population level and compare these rates over time against historical averages to identify the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resulting control measures on community prescribing.

Methods
We collected antibiotic prescriptions and physician office visits from January 1, 2016, to July 21, 2020. We calculated monthly prescription rates stratified by sex, age group, profession, diagnosis type, and antibiotic class. We looked at monthly prescription rate as a moving average over time. Using the interrupted time series analysis method, we estimated the changes in prescription rates after March 2020.

Results
The moving average of overall monthly prescription rates during January–June 2020 was below the minimum of the historical years’ moving averages (2016–2019). We observed a &gt;30% reduction in overall monthly prescription rates in April, May, and July of 2020 compared with the same months of 2019. We observed that overall monthly prescription rates experienced a significant level change of –12.79 (P &lt; .001) during the coronavirus disease 2019 pandemic after March 2020, with the greatest level change being –18.02 among children 1–4 years of age (P &lt; .001). We estimated an average –5.94 (P &lt; .001) change in respiratory tract infection (RTI)–associated monthly prescription rates after March 2020. Overall prescription rates comparing January–July 2019 and their 2020 counterparts showed a decrease in monthly prescribing ranging from –1 to –5 for amoxicillin, amoxicillin and enzyme inhibitors, azithromycin, clarithromycin, and sulfamethoxazole.

Conclusions
In British Columbia, Canada, overall and RTI-specific monthly antibiotic prescription rates declined significantly during April–July 2020 compared with the same months in prepandemic years.
Cytomegalovirus Transmitted From Mother's Own Milk to a Growth-Restricted Extremely Preterm Infant
Authors: Work Benedicte Juul , Volder Christina , Fenger-Gron Jesper , Zachariassen Gitte 
Published: April 2021

Background:
Mother's own milk (MOM) is considered the optimal nutrition for preterm infants. Unfortunately, MOM can contain human cytomegalovirus (HCMV), which can be transmitted to the infants. Postnatal HCMV infection in very preterm infants can lead to organ failure.

Clinical Findings:
In this case we report cholestasis possibly associated to HCMV transmitted through MOM in a very growth-restricted extremely preterm infant.

Primary Diagnosis:
The primary diagnosis is postnatal HCMV infection.

Interventions:
The infant was too preterm to be treated with antiviral medication. Instead, he was treated with a diet with no fresh MOM but only freeze-thawed MOM to reduce the viral load.

Outcomes:
Conjugated bilirubin values normalized after the infant was fed freeze-thawed MOM with a reduced viral load and formula.

Practice Recommendations:
The awareness of HCMV-positive mothers giving birth to extremely preterm infants should be increased. Feeding only freeze-thawed MOM or in combination with fresh MOM should be considered prophylactically to avoid transmission of high viral loads of HCMV to these vulnerable infants.
What's new in bone disease and fractures in HIV?
Authors: Alvarez-Barco Elena , Mallon Patrick W.G. 
Published: April 2021

Purpose of review
People living with HIV (PWH) are at greater risk of low bone mineral density (BMD) and fractures compared to the general population. This narrative review summarises recent literature in the field, including the relative contribution of antiretroviral therapy and frailty to low BMD and fractures in PWH.

Recent findings
The body of evidence indicating less impact on BMD from the use of tenofovir alafenamide compared to tenofovir disoproxil fumarate continues to grow, although this has not yet translated into data supporting a reduction in fracture incidence. Frailty, common in PWH, is associated with both fractures and alterations in renal-bone metabolism, but is an area that is understudied in relation to interventions to reduce fracture risk in PWH.

Summary
Although a maturing field, research into interventions to reduce fracture incidence in PWH is lacking in both quantity and scope. Development of core outcome datasets for clinical trials along with trials focused on reducing or reversing frailty are required to guide improvements overall bone health outcomes in PWH.
Death and Dying in Prison: An Integrative Review of the Literature
Authors: Petreca Victor G. 
Published: April 2021

ABSTRACT

Objective
The purpose of this integrative review was to synthesize and explore the qualitative research literature that describes the experience of being terminally ill while incarcerated, in order to inform future inquiry when it comes to the end-of-life (EOL) needs of incarcerated persons.

Background
Mass incarceration has been a major issue in the United States, with rates sharply increasing since the 1970s. In the past two decades, the number of older incarcerated persons has grown by 500%, highlighting the importance of EOL care and decisions among this demographic.

Methods
The search terms included prison OR incarceration AND “death and dying” OR “end of life.” Primary research articles were considered in the search parameters. The Joanna Briggs Institute critical appraisal checklist for qualitative research was coupled with ConQual to score the quality of the selected qualitative studies.

Results
Searches yielded 233 articles published after 2000. Following screening, 29 full-text articles were assessed for eligibility, and 7 qualitative studies met criteria and were included in the review. The ConQual scores of the synthesized findings were determined to be either “low” or “moderate.”

Discussion
Five main categories were observed across the themes elicited by the studies: EOL services in prison, social contact and human interactions, thoughts of death and fear of dying, wishes and decision-making, and guilt and coping. Many of these themes may be considered by correctional nurses who provide supportive “good death” care for incarcerated persons who are dying.
Comparison of 2 shear wave elastography systems in reproducibility and accuracy using an elasticity phantom
Authors: Woo Jung Han , Ko Eun Young , Han Boo-Kyung 
Published: April 2021

Abstract
This study aimed to compare the accuracy and inter- and intra-observer reproducibility of the measured elasticity between 2 shear wave elastography systems. Three breast radiologists examined 8 targets of 4 different levels of stiffness (size: 11 mm, 4 mm) in an elasticity phantom (Customized 049A Elasticity QA Phantom, CIRS, Norfolk, VA, USA) using 2 different shear wave ultrasound elastography systems: SuperSonic Imagine (SSI) (SSI, Aix en Provence, France) and ShearScan (RS-80A, Samsung Medison, Seoul, Korea). Three radiologists performed ultrasound (US) elastography examinations for the phantom lesions using 2 equipment over a 1-week interval. Intra- and inter-observer reproducibility and the accuracy of the measured elasticity were analyzed and compared between the 2 systems. The accuracy of shape was also analyzed by shape-matching between B-mode and elastography color image. Intra-class correlation coefficients (ICC) were used in statistical analysis. For measured elasticity, the intra-observer and inter-observer reproducibility were excellent in both SSI and ShearScan (0.994 and 0.998). The overall accuracy was excellent in both systems, but the accuracy in small lesions (4 mm target) was lower in SSI than ShearScan (0.780 vs 0.967). The accuracy of shape-matching on the elastography image was 59.0% and 81.4% in the SSI and ShearScan, respectively. In conclusion, the SSI and ShearScan showed excellent intra- and inter-observer reproducibility. The accuracy of the Young's modulus was high in both the SSI and ShearScan, but the SSI showed decreased accuracy in measurement of elasticity in small targets and poor shape-matching between the B-mode image and color-coded elastography image.
The efficacy of moxibustion and acupuncture therapy for ankylosing spondylitis
Authors: Zhu Qingyuan , Chen Jun , Xiong Jun , Lu Lunbin , Zhu Siyuan , Zhong Zhiying , Tang Genhua , Zhou Xingchen , Guo Han 
Published: April 2021

Abstract

Background:
Ankylosing spondylitis is a complex and progressive autoimmune inflammatory disease with a worldwide prevalence ranging up to 0.9%. Several systematic reviews and meta-analyses of traditional Chinese medicine alternative therapies, such as acupuncture or moxibustion, have demonstrated the effectiveness of moxibustion and acupuncture in the treatment of ankylosing spondylitis. However, there is no relevant literature to comprehensively evaluate the evidence. The purpose of this overview is to synthesize and evaluate the reliability of evidence generated in the systematic review (SR) and meta-analysis of moxibustion and acupuncture as a primary or complementary therapy for patients with ankylosing spondylitis.

Methods:
PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, Chinese National Knowledge Infrastructure, Chinese VIP Information, Wanfang Database, and Chinese Biomedical Literature Database were searched for systematic reviews and meta-analysis that review the efficacy of acupuncture or moxibustion as the primary treatment for patients with Ankylosing Spondylitis. The literature published before August 2020 will be selected. Additionally, the relevant SRs and meta-analyses that unpublished or ongoing will be searched in PROSPERO and INPLASY. The methodological guidelines for overviews will be used to review and extract data by 2 reviewers, and their will do it independently. Methodology quality will be analyzed by the assessment of multiple systematic reviews-2and the risk of bias by POBIS. For the included studies, we will adopt the following results as primary evaluation indicators: effective rate, visual analogue scale and bath AS disease activity index. Reviewers will assess the certainty of evidence by Grading of Recommendations Assessment, Development and Evaluation.

Results:
The results will be published in a peer-reviewed journal.

Conclusion:
This overview will provide comprehensive evidence of moxibustion and acupuncture for patients with Ankylosing Spondylitis.
Internal medicine residency program director perceptions of USMLE Step 1 pass/fail scoring
Authors: Mun Frederick , Scott Alyssa R. , Cui David , Chisty Alia , Hennrikus William L. , Hennrikus Eileen F. 
Published: April 2021

Abstract
The United States Medical Licensing Examination Step 1 will transition to a pass/fail exam starting no earlier than January 2022. Internal medicine residency programs will need to adapt to these changes. The purpose of this study was to investigate:
A validated REDCap survey was sent to 548 program directors at active Accreditation Council for Graduate Medical Education internal medicine residency programs. Contact information from the American Medical Association's Fellowship and Residency Electronic Interactive Database was used.
The survey had 123 respondents (22.4%). Most internal medicine program directors do not support the pass/fail change. A greater importance will be placed on Step 2 Clinical Knowledge exam, personal knowledge of the applicant, clerkship grades, and audition electives. Allopathic students from less highly regarded medical schools, as well as osteopathic and international students, will be disadvantaged. About half believe that schools should adopt a graded pre-clinical curriculum (51.2%) and that there should be residency application caps (54.5%).
Internal medicine program directors mostly disagree with the pass/fail Step 1 transition. Residency programs will need to reevaluate how applicants are evaluated. Other factors, such as Step 2 Clinical Knowledge score, personal knowledge of the applicant, grades in clerkships, and audition rotations will now be emphasized more heavily.
The incidence and prognosis of thymic squamous cell carcinoma
Authors: Wu Jingyi , Wang Zhijun , Jing Caibao , Hu Yang , Yang Bing , Hu Yanping 
Published: April 2021

Abstract

Background:
Thymic carcinoma represents a rare type of malignant mediastinal tumor and has been the subject of controversy. Although independent prognostic factors related to thymic carcinoma have been investigated previously, few studies have focused specifically on the survival outcomes associated with thymic squamous cell carcinoma (TSCC). This study aims at presenting a survival analysis in this rare malignant disease at population level.

Methods:
We extracted the data of 216 patients with TSCC recorded from 1973 to 2015 from the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute. The patients’ demographic features, clinical traits, and treatment factors were analyzed in order to identify prognostic factors, which correlate overall survival using the Kaplan–Meier method as well as a multivariate Cox regression model, for TSCC.

Results:
The majority of patients were male, Caucasian, married, and insured. Furthermore, 58.3%, 54.6%, and 59.7% of patients TSCC underwent surgery, radiotherapy, and chemotherapy respectively. In a multivariate analysis, age of diagnosis (hazard ratio [HR]: 1.022, 95% confidence interval [CI]: 1.003–1.040, P = .020), surgical treatment (HR: 0.282, 95% CI: 0.164–0.484, P = .000), and stage (regional vs distant HR: 0.532, 95% CI: 0.324–0.872, P = .013; localized vs distant HR: 0.297, 95% CI: 0.133–0.664, P = .003) correlated with increased overall survival, whereas adjuvant therapy, including chemotherapy and radiotherapy, did not correlate with survival. Among surgically treated patients, age of diagnosis and stage were associated with better overall survival, while chemotherapy and radiotherapy did not contribute significantly to overall survival.

Conclusion:
Surgery, age of diagnosis, and stage were associated with better overall survival among TSCC.
Effects of continuous use of metformin on cardiovascular outcomes in patients with type 2 diabetes after acute myocardial infarction
Authors: Shen Chuanwen , Tan Shuying , Yang Jun 
Published: April 2021

Abstract

Background:
To our knowledge, no meta-analyses or reviews have investigated the efficacy and safety of metformin on cardiovascular outcomes after acute myocardial infarction (AMI) in patients with type 2 diabetes mellitus (T2DM). We thus conduct a high-quality systematic review and meta-analysis to assess the efficacy and safety of metformin on cardiovascular outcomes after AMI in patients with T2DM.

Methods:
In this systematic review and meta-analysis, we will search PUBMED, Scopus, EMBASE, and Cochrane Library databases through April, 2021. The study is structured to adhere to PRISMA guidelines (i.e., Preferred Reporting Items for Systematic Reviews and Meta-analyses). The literature search, data extraction, and quality assessments are conducted independently by 2 authors. Outcome measures include all-cause mortality; complications such as acute kidney injury, lactic acidosis, hospitalization for AMI or stroke, or death. Where disagreement in the collection of data occurs, this is resolved through discussion. Review Manager Software (v 5.3; Cochrane Collaboration) is used for the meta-analysis. Two independent reviewers will assess the risk of bias of the included studies at study level.

Results:
It is hypothesized that metformin use at the post-AMI is associated with decreased risk of cardiovascular disease and death in patients with T2DM.

Conclusions:
This study expects to provide credible and scientific evidence for the efficacy and safety of metformin on cardiovascular outcomes after AMI in patients with T2DM.

Registration number:
10.17605/OSF.IO/S3MBP.
Clinical study of combined application of indocyanine green and methylene blue for sentinel lymph node biopsy in breast cancer
Authors: Zhang Chenguang , Li Yongtao , Wang Xiaowen , Zhang Mingshuai , Jiang Weihua , Ou Jianghua 
Published: April 2021

Abstract

Objective:
This study aims to investigate the feasibility of combined application of indocyanine green (ICG) and methylene blue (MB) for sentinel lymph node biopsy (SLNB) in patients with early breast cancer.

Methods:
A total of 415 patients who underwent SLNB and axillary lymph node dissection were enrolled. Sentinel lymph node (SLN) was assessed in 197 patients with ICG and MB combination method, while, the other 218 patients were detected by MB method alone. During surgery, all SLNs were harvested for pathological examination. Then the detection rate and false negative rate of SLNs were comparatively analyzed between the 2 groups.

Results:
In the combined ICG and MB group, the detection rate of SLNs was 96.9%, significantly higher than that of MB group, which was 89.7% (P < .05). Similarly, in combined group, the average number of SLNs per patient was 3.0, much higher than that of MB group, which was 2.1 (P < .05). There was no statistically significant difference in false negative rate between combined group and MB alone group, which was 7.3% and 10.5%, respectively (P = .791).

Conclusion:
The combined application of ICG and MB for SLNB is much more effective than MB alone in detecting SLNs.
Prevalence and risk factors for obesity among elderly patients living with HIV/AIDS in a low-resource setting
Authors: Dakum Patrick , Avong Yohanna Kambai , Okuma James , Sorungbe Temilade , Jatau Bolajoko , Nedmbi Nicaise , Odutola Michael Kolawole , Abimiku Alash’le , Mensah Charles Olalekan , Kayode Gbenga Ayodele 
Published: April 2021

Abstract
Obesity is associated with detrimental changes in cardiovascular and metabolic parameters, including blood pressure, dyslipidemia, markers of systemic inflammation, and insulin resistance. In the elderly living with the human immunodeficiency virus (EPLHIV), and being treated with antiretroviral medications, the obesity complications escalate and expose the elderly to the risk of noncommunicable diseases. Given that over 3 million EPLHIV in sub-Sahara Africa, we assessed the prevalence of obesity and its associated factors among EPLHIV in a low-resource setting.
This was a cross sectional study of EPLHIV aged 50 years and older, being treated with antiretroviral medications from 2004 to 2018. HIV treatment data collected from multiple treatment sites were analyzed. Baseline characteristics of the participants were described, and multivariable relative risk model was applied to assess the associations between obesity (body mass index [BMI] ≥30 kg/m2) and the prespecified potential risk factors.
Of the 134,652 in HIV cohort, 19,566 (14.5%) were EPLHIV: 12,967 (66.3%) were normal weight (18.5 ≤ BMI < 25), 4548 (23.2%) were overweight (25 ≤ BMI < 30), while 2,051 (10.5%) were obese (BMI ≥30). The average age the normal weight (57.1; standard deviation 6.6) and the obese (56.5; standard deviation 5.5) was similar. We observed that being an employed (relative risk [RR] 1.71; 95% confidence interval [CI] 1.48–2.00; P < .001), educated (RR 1.93; 95% CI 1.54–2.41; P < .001), and presence of hypertension (RR 1.78; 95% CI 1.44–2.20; P < .001), increased the risk of obesity. Also, being male (RR 0.38; 95% CI 0.33–0.44; P < .001), stages III/IV of the World Health Organization clinical stages of HIV (RR 0.58; 95% CI 0.50–0.68; P < .001), tenofovir-based regimen (RR 0.84; 95% CI 0.73–0.96, P < .001), and low CD4 count (RR 0.56; 95% CI 0.44–0.71; P < .001) were inversely associated with obesity.
This study demonstrates that multiple factors are driving obesity prevalence in EPLHIV. The study provides vital information for policy-makers and HIV program implementers in implementing targeted-interventions to address obesity in EPLHIV. Its findings would assist in the implementation of a one-stop-shop model for the management of HIV and other comorbid medical conditions in EPLHIV.
Risk factors of in-stent restenosis in patients with diabetes mellitus after percutaneous coronary intervention
Authors: Li Suiping , Luo Chao , Chen Haimei 
Published: April 2021

Abstract

Background:
Percutaneous coronary intervention (PCI) has become one of the effective methods for the treatment of coronary heart disease (CHD). However, it is easy to have in-stent restenosis (ISR), even cardiovascular events after PCI, which affects the therapeutic effects. The incidence of ISR in diabetes mellitus (DM) patients increased by 2 to 4 times. Early identification of the risk factors of ISR in DM patients after PCI may help clinical staff to prevent and intervene as soon as possible, so it is very important to improve the clinical outcomes of DM patients. Although scholars at home and abroad have studied and summarized the risk factors of ISR in DM patients after PCI, the conclusions are different. Therefore, in this study, meta-analysis was used to summarize the risk factors of ISR in DM patients after PCI, and to explore the characteristics of high-risk groups of ISR, thus providing reference for early identification and prevention of ISR.

Methods:
We will search related literature from PubMed, Embase, Cochrane Library, Web of Science, China Biology Medicine Database, China National Knowledge Infrastructure, China Science and Technology Journal Database, and Wanfang Database. Eligible studies will be screened based on inclusion criteria. Meanwhile, data extraction, risk of bias assessment, publication bias assessment, subgroup analysis, and quality assessment will be performed. Review Manager Version 5.3 software will be applied for data analysis. Each process is independently conducted by 2 researchers. If there is any objection, it will be submitted to a third researcher for resolution.

Results:
We will disseminate the findings of this systematic review and meta-analysis via publications in peer-reviewed journals.

Conclusions:
The results of this analysis can be used to generate a risk prediction model and provide an intervention strategy for the occurrence of ISR in DM patients after PCI.

OSF REGISTRATION NUMBER:
DOI 10.17605/OSF.IO/WC87Y.