bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating Serum Exosomal Long Non-Coding RNAs FOXD2-AS1, NRIR, and XLOC_009459 as Diagnostic Biomarkers for Colorectal Cancer
Authors: Yu Miao , Song Xing-guo , Zhao Ya-jing , Dong Xiao-han , Niu Li-min , Zhang Zhi-jun , Shang Xiao-ling , Tang You-yong , Song Xian-rang , Xie Li 
Published: March 2021

BackgroundExosomes derived from cancer cells encapsulate various kinds of tumor-specific molecules and thus can interact with adjacent or distant cells to mediate information exchange. Long non-coding RNAs (lncRNAs) in exosomes have the potential as diagnostic and prognostic biomarkers in different types of cancers. The current study was aimed to identify circulating exosomal lncRNAs for the diagnosis of colorectal cancer (CRC).MethodsExosomes were isolated from the serum by ultracentrifugation and verified by transmission electron microscope (TEM), qNano, and immunoblotting. Exosomal lncRNAs FOXD2-AS1, NRIR, and XLOC_009459 were selected by lncRNA microarray and validated by qPCR in 203 CRC patients and 201 healthy donors. The receiver operating characteristic curve (ROC) was used to assess the diagnostic efficiency of serum exosomal lncRNAs.ResultsExosomal FOXD2-AS1, NRIR, and XLOC_009459 (TCONS_00020073) levels were significantly upregulated in 203 CRC patients and 80 early-stage CRC patients compared to 201 healthy donors, possessing the area under the curve (AUC) of 0.728, 0.660, and 0.682 for CRC, as well as 0.743, 0.660, and 0.689 for early-stage CRC, respectively. Notably, their combination demonstrated the markedly elevated AUC of 0.736 for CRC and 0.758 for early-stage CRC, indicating their potential as diagnostic biomarkers for CRC.ConclusionsOur data suggested that exosomal lncRNAs FOXD2-AS1, NRIR, and XLOC_009459 act as the promising biomarkers for the diagnostics of CRC and early-stage CRC.
Identification of a Novel Four-Gene Signature Correlated With the Prognosis of Patients With Hepatocellular Carcinoma: A Comprehensive Analysis
Authors: Zhu Weihua , Ru Lixin , Ma Zhenchao 
Published: March 2021

PurposeHepatocellular carcinoma (HCC) is a common solid-tumor malignancy with high heterogeneity, and accurate prognostic prediction in HCC remains difficult. This analysis was performed to find a novel prognostic multigene signature.MethodsThe TCGA-LIHC dataset was analyzed for differentially coexpressed genes through weighted gene coexpression network analysis (WGCNA) and differential gene expression analysis. A protein-protein interaction (PPI) network and univariate Cox regression analysis of overall survival (OS) were utilized to identify their prognostic value. Next, we used least absolute shrinkage and selection operator (LASSO) Cox regression to establish a prognostic module. Subsequently, the ICGC-LIRI-JP dataset was applied for further validation. Based on this module, HCC cases were stratified into high-risk and low-risk groups, and differentially expressed genes (DEGs) were identified. Functional enrichment analyses of these DEGs were conducted. Finally, single-sample gene set enrichment analysis (ssGSEA) was performed to explore the correlation between the prognostic signature and immune status.ResultsA total of 393 differentially coexpressed genes were obtained. Forty differentially coexpressed hub genes were identified using the CytoHubba plugin, and 38 of them were closely correlated with OS. Afterward, we established the four-gene prognostic signature with an acceptable accuracy (area under the curve [AUC] of 1-year survival: 0.739). The ICGC-LIRI-JP dataset also supported the acceptable accuracy (AUC of 1-year survival:0.752). Compared with low-risk cohort, HCC cases in the high-risk cohort had shorter OS, higher tumor grades, and higher T stages. The risk scores of this signature still act as independent predictors of OS (P&lt;0.001). Functional enrichment analyses suggest that it was mainly organelle fission and nuclear division that were enriched. Finally, ssGSEA revealed that this signature is strongly associated with the immune status of HCC patients.ConclusionsThe proposed prognostic signature of four differentially coexpressed hub genes has satisfactory prognostic ability, providing important insight into the prediction of HCC prognosis.
Art Therapy Alleviates the Levels of Depression and Blood Glucose in Diabetic Patients: A Systematic Review and Meta-Analysis
Authors: Yang Qingqi , Shao Qunhui , Xu Qiang , Shi Hui , Li Lin 
Published: March 2021

Objective: To systematically analyze the effects of art therapy on the levels of depression, anxiety, blood glucose, and glycated hemoglobin in diabetic patients.Methods: We searched Cochrane Library, PubMed, Embase, and ClinicalTrials.gov databases from inception to January 24, 2021. The language of publication was limited to English. Randomized controlled trials (RCTs) that used art therapy to improve mental disorders in diabetic patients were involved. After selection of eligible studies, data were extracted, including the first author's full-name, year of publication, the first author's country of residence, number of intervention and control groups, the mean age of participants, method of intervention, duration of follow-up, and outcome measures. Assessment of quality of the included studies and data extraction were independently carried out by two researchers. RevMan 5.3 software was used to perform statistical analysis.Results: A total of 396 samples from five studies were included, and the eligible studies were RCTs with a parallel design. Methods of art therapy included music therapy and painting therapy. The results showed that compared with the control group, art therapy could positively affect the levels of depression [standardized mean difference (SMD), −1.36; 95% confidence interval (CI), (−1.63, −1.09); P &lt; 0.00001] and blood glucose in diabetic patients [mean difference (MD), −0.90; 95% CI, (−1.03, −0.77); P &lt; 0.0001], while it had no influence on the levels of anxiety [SMD, −0.31; 95% CI, (−0.93, 0.31); P = 0.32] and glycated hemoglobin [MD, 0.22; 95% CI, (−0.02, 0.46); P = 0.07].Conclusion: Art therapy may have significant effects on the levels of depression and blood glucose for diabetic patients.
Characterization and Performance Analysis of BST-Based Ferroelectric Varactors in the Millimeter-Wave Domain
Authors: Crunteanu Aurelian , Muzzupapa Vincent , Ghalem Areski , Huitema Laure , Passerieux Damien , Borderon Caroline , Renoud Raphael , Gundel Hartmut W. 
Published: March 2021

We present the realization and analysis of the microwave performances of interdigited varactors integrating thin ferroelectric layers of barium and strontium titanate (BaxSr1−xTiO3). Devices based on ferroelectric films of different compositions (x = 0.8 and x = 0.5) have been characterized in the millimeter-wave domain, from 200 MHz to 110 GHz. By applying different bias voltages, the tunability of the capacitance can reach up to 40% for the Ba0.8Sr0.2TiO3 composition, under relatively low applied electric fields of about 167 kV/cm. These promising characteristics allow the integration of the varactor devices in tunable antennas for a large frequency domain, from the microwaves to the millimeter waves range.
La organización de los juzgados urbanos: los jueces de paz en su quehacer cotidiano, entre recursos materiales y tramas administrativas (Rosario, 1854-1872)
Authors: De los Rios Evangelina 
Published: March 2021

El artículo examina el funcionamiento de los juzgados de paz urbanos de la ciudad de Rosario entre 1854 y 1872. Se muestra que estos juzgados tuvieron un papel central en el proceso de reordenamiento político-institucional que buscaba acercar los ámbitos de justicia a la población. En este sentido, el análisis no se ciñe a las orientaciones normativas e institucionales adoptadas por las autoridades del estado sino que atiende, al mismo tiempo, al quehacer cotidiano de los diferentes agentes sociales. Se estudian las tramas administrativas en que se hallaban insertos los jueces de paz y sus comunicaciones con diferentes agentes sociales -jefes de policía, jefes políticos, jueces de primera instancia-, la composición de los juzgados - tenientes y demás auxiliares- y la dinámica y la materialidad en que se desenvolvieron en el ejercicio de sus funciones.
Use of L1 in the Iranian EFL Classroom
Authors: Masoumi Mayni Setareh , Paramasivam Shamala 
Published: March 2021

By reviewing the literature on the development of English language teaching methods in the last three decades, it is obvious that the idea of using the first language (L1) in the second language (L2) classroom has always been controversial. The history of language pedagogy and the role of the first language in foreign language learning generate debates in English as a foreign language. The teaching of English as a foreign language is growing every day in Iran, and as a result, the need for informing the best policy is getting more urgent. The principal intent of the current study, that investigates the use of L1 in the English classroom, is to determine teachers, students and policymakers’ beliefs and attitudes towards the use of L1 in L2 classroom. The L1, in this case, is Farsi language and all the participants are native speakers of Farsi. One hundred and fifty students of the English Language Department at the elementary level at Tehran Institute of Technology are the participants of the study. They are all female and in their late teens or early twenties. The students and the teachers were surveyed by questionnaires and the researcher observed 10 classes and interviewed 3 teachers and 3 policymakers. The information gathered from the questionnaire was submitted to SPSS for analyzing the data, and the information gathered from the interview. Class observation check-list was used to triangulate the findings of the questionnaire. The results of this study indicate that teachers and students have different attitudes towards using L1 in the EFL classes. While students have a positive attitude, teachers have a negative attitude. The main reason mentioned by students for not being against the limited use of Farsi in their English class is that they believe using Farsi even in a limited sense can help them to understand difficult concepts. However, teachers believe in an English-only policy to be more exposed to the English language. Another finding of this study is that the functions of using Farsi by students or teachers in EFL classroom are: for explaining difficult parts, for managing the classroom, for explaining exam instructions, for explaining the two language differences, for checking comprehension, for seeking help from others, for joking with others, for making students relaxed and for presenting the meaning of new words. Given these findings, to match the student’s and teachers’/policymakers’ ideas about using L1 at the elementary level, an EFL teaching methodology that considers the use of Farsi, even in a limited way, is suggested.
Examining the Relationship between the Sense of Humor and the Social Exclusion Perceived by Gifted and Talented Students
Authors: Demir Serkan , Konik Ayça 
Published: March 2021

This research aimed to establish the relationship between the social exclusion perceived by gifted and talented students and their sense of humor. Besides, the goal was to evaluate the relationship between the variables of the use of humor, the process of coping through a sense of humor, and the appreciating humor in cases of ignoring and avoiding during social exclusion. A relational screening model was used in the research. Among the research variables included in the model, social exclusion (ostracism) is considered as a dependent variable, while the sense of humor is an independent variable. The study group is composed of 202 students who are diagnosed as gifted and talented students. Within the scope of the study, the “Multidimensional Sense of Humor Scale for Children” developed by Akın and Bilgin (2015) and the “Social Exclusion Scale for Adolescents” developed by Sertelin Mercan (2016) have been applied. When the data collected as a result of the study was examined, it was revealed that there was a positive relationship between the sub-dimensions of generating a sense of humor, coping through humor, and appreciating humor, which is the sense of humor sub-dimensions of gifted and talented students and the exclusion subdimension of social exclusion. This situation shows that gifted and talented children generate a sense of humor, cope with this situation through humor, and appreciate humor when they face exclusion in their social environment.
Continuing Professional Development of Teacher Educators: Challenges and Initiatives
Authors: Tyagi Chanchal , Misra Pradeep Kumar 
Published: March 2021

Continuing Professional Development (CPD) is a prerequisite for teacher educators. The importance of CPD for teacher educators lies in the fact that it helps them to improve their professional and instructional practices. Teacher educators usually begin their CPD after joining the profession and continue it as a lifelong learning process. There are two popular routes of CPD for teacher educators: programs planned and mandated by external agencies and their self-initiatives. Researchers conducted in different parts of the world reveal that, like external initiatives, selfinitiative also play an important role in the professional development of teacher educators. As part of their self-initiatives for CPD, teacher educators themselves act as the developers and creators of their professional learning opportunities and activities. Researches also depict that some factors may negatively affect teacher educators’ attitude and capacity to initiate his/her CPD activities. Extending all these arguments, the present study aimed to study teacher educators’ self-initiatives of CPD and the challenges they face in this journey. Data to conduct the study was collected from a sample of 120 teacher educators’ by using ‘Teachers’ CPD Initiatives Scale’ & ‘Teachers’ CPD Challenges Scale’, and analyzed by using percentage and product-moment r.
Factores asociados con estancia hospitalaria prolongada en una unidad geriátrica de agudos
Authors: Ojeda Méndez Carlos Aaron , Palomino Pacichana Diana Sofia , Bejarano Barragán Liliana , Ocampo-Chaparro José Mauricio , Reyes-Ortiz Carlos Alfonso 
Published: March 2021

Objetivo: Analizar los factores asociados con estancia hospitalaria prolongada en una Unidad Geriátrica de Agudos de un hospital general.
Material y métodos: Incluyó 2014 pacientes ≥60 años hospitalizados entre enero 2012 y septiembre 2015. La variable dependiente fue la estancia hospitalaria (>10 días vs ≤10 días). Variables independientes incluyeron las sociodemográficas, de laboratorio, comorbilidad, estado funcional y mental. Para análisis bivariado se empleó la prueba de Chi2 para variables categóricas y de Wilcoxon Two-Sample no-paramétrico para las cuantitativas. Se realizó un modelo multivariado de regresión logística.
Resultados: El 51,1% fueron mujeres y la edad promedio fue 82,3 años (DE ± 7,2 años). El 50,6% tuvieron estancia prolongada, con un promedio de estancia de 14.7 días (DE ± 14 días). La asociación más fuerte con la estancia hospitalaria prolongada fue el desarrollo de Úlceras por Presión (OR 2,30 IC 95% 1,56-3,39). El deterioro cognitivo moderado o severo, la dependencia funcional, anemia, hipoalbuminemia y niveles elevados de reactantes de fase aguda (PCR) se asociaron con hospitalizaciones prolongadas. Ser mujer estuvo asociado a menos días de hospitalización. La estancia prolongada no se relacionó con las variables sociales.
Conclusión: Los principales factores independientes asociados a la estancia prolongada fueron las ulceras por presión, la dependencia funcional, la hipoalbuminemia y los niveles elevados de PCR.
Descripción de los pacientes de 80 o más años intervenidos quirúrgicamente en el laboratorio de electrofisiología en un hospital de tercer nivel
Authors: Acosta Sánchez Daniela , Bautista Vargas William Fernando 
Published: March 2021

Introducción: en una unidad de electrofisiología de un hospital de tercer nivel de Manizales, Caldas, se han atendido pacientes en la cuarta edad; sin embargo, existe poca claridad en la literatura sobre las conductas terapéuticas en este grupo etario. Presentamos nuestra experiencia de atención e intervención en pacientes mayores de 80 años entre el 20 de septiembre de 2017 y 7 de octubre de 2019.
Métodos: estudio tipo cohorte longitudinal, se recogió información con base en revisión de historias clínicas. Se realizaron seguimientos telefónicos al tercer y sexto mes del procedimiento. Se incluyeron pacientes mayores de 80 años intervenidos de cualquier procedimiento en la sala de electrofisiología. Se excluyeron los pacientes sin información sobre los datos de seguimiento.
Resultados: se recogieron datos de 75 pacientes llevados a procedimiento. El 62.7% de los pacientes fueron hombres, las edades oscilaron entre 80 y 95 años. 32.7%, de pacientes con diagnóstico de disfunción sinusal. La comorbilidad más prevalente fue hipertensión arterial (92%). El procedimiento más realizado fue el implante de marcapaso bicameral. La mediana del tiempo de estancia hospitalaria fue de 1 día. EL 70% de los pacientes tuvieron riesgo medio o bajo según la escala CHA2DS2VASc. En el lapso de seis meses se encontró una incidencia acumulada de complicaciones de 4%, con 8% de reconsultas y una mortalidad de 1.3%.
Conclusiones: las complicaciones posquirúrgicas, la necesidad y duración de la hospitalización, la tasa de reconsulta y la mortalidad asociada a los procedimientos en este grupo de edad son similares a las observadas en estudios con población menor de 80 años.
دراسة اداء المتعلمين العراقيين للغة الانكليزية لغة اجنبية في استخدام العبارات الاصطلاحية
Authors: Jundi  Ali Ahmed , Ali Dawood ZeenaAbid 
Published: March 2021

This research is devoted to study the performance of Iraqi EFL learners with reference to idiomatic expressions in modern Standard English.By definition , an idiom is a linguistic unit in which the meaning of a given construction cannot be understood from the words that compose it. Evidence shows that English idiomatic expressions represent a rather problematic area for EFL learners . Thus , this study aims at theoretically investigating the English idiomatic expressions and practically studying the Iraqi EFL learners' performance in dealing with these expressions by means of a specialized test designed for this purpose . It is hypothesized that Iraqi EFL learners face difficulties in dealing with idiomatic expressions in both recognition and production levels . The test includes two questions , each with 25 items. Results show that , at the recognition level ( question 1) , most Iraqi EFL learners fail in recognizing the idiomatic expressions , whereas at the recognition level the percentage of learners unable to employ the given idiomatic expressions increased including the avoided items , which are considered as incorrect in both first and second questions . The findings arrived at support the above mentioned hypothesis . The study ends with some of the recommendations for EFL teachers and learners and the way they encounter such expressions in spoken and written English
Роль В.Пелевина,В.Маканина и В.Сорокина в развитии современной русской литературы
Authors: Ali Khudair Bahari Hussein 
Published: March 2021

The present paper tackles the viewpoints of Russian literary critics, and their evaluation of contemporary writers, along with their roles in the development of the Twenty-First century literature. We have pointed out the importance of the works of Viktor Pelevin, Valdimir Makanin, and Vladimir Sorokin, and how they influenced modern Russian literature. Also, it has been showed that these writers were not less important than the Russian classic writers, despite that some of their works were characterized with a sense of dialectic with the classic text. Thus, a contemporary Russian text has become desired and understood all over the world.
القمر في الثقافة العراقية القديمة: اعادة قراءة لرواية" الهلال" لديانا ابو جابر و"طشاري" لأنعام كججي
Authors: Hashim Taher Asst. Prof. Isra 
Published: March 2021

Man used to attribute good and evil in his life to celestial bodies. Therefore, ancient civilizations paid much attention to astronomy which had a lasting impact on mythology and religion. In ancient Iraqi mythology, sad and happy events like war and peace, death and fertility, flood and famine, were attributed to the appearance and disappearance of the moon.Among the post-modern writers who wrote novels about Iraq are the Arab-American Diana Abu Jaber (1959 -) and the Paris-based Iraqi Inaam Kachachi (1952 -). Abu Jaber's Crescent (2003) tells a love story between an Iraqi professor and an Iraqi-American girl. The crescent of the title has to do with the Islamic ritual of marking the beginning of a lunar month like Ramadhan. As the novel suggests it has to do with patience and the unknown as represented by the sudden and unexpected reappearance of the protagonist (Hanif) after a long time of absence. Whereas Kachachi's Tashari (2013) details the scattering of Iraqis in different parts of the world after the-2003 events. It attributes this tragedy to the Pope's refusal to visit the city of Ur, the birthplace of Prophet Abraham which also used to be the residence of Nana, the moon god of the ancient Sumerians. While apparently both novels deal in part with the religious beliefs and practices related to the moon in Islam and Christianity, they, however, make no direct reference to ancient Iraqi myths. Although Abu Jaber expressed the wish of writing about "the legacy of Iraq", "the cradle of civilization" and Kachachi wrote mainly about Iraq and its " good old days", but rarely they made a direct reference to the moon and its significance in ancient Iraqi culture. Nevertheless, both novels implicitly abound in references to the moon that can be analyzed in terms of its status and the lasting impact it had on ancient Iraqi culture, which will be the focus of this paper.
Pengaruh Kecepatan, Temperatur dan Infill Terhadap Kualitas dan Kekasaran Kotak Relay Lampu Sign Sepedamotor Hasil dari 3D Printing
Authors: Panjaitan Joy H , Tampubolon Miduk , Sihombing Fiktor , Simanjuntak Jamser 
Published: March 2021

3D printing technology has great potential in today's manufacturing world where one of its uses is in the prototype of a product. One of the most famous and inexpensive 3D printing technologies is the Fused Deposition Modeling (FDM) method. Many studies have been carried out using this FDM method.
In this study, the printing of motorbike light relay boxes was carried out using the FDM method with two variations of speed, temperature and infill of each mass. 3D Printing uses a nozzle diameter of 0.4 mm and a work table temperature of 60oC and a height of 0.2 mm for each layer with support every where. From the research results, all the products produced have a rough surface with a level of geometric accuracy ranging from 0.91% for the length dimension and 7.73% for the width dimension of the product.