bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasma p‐tau181 shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau
Authors: Frank Brandon , Ally Madeline , Brekke Bailee , Zetterberg Henrik , Blennow Kaj , Sugarman Michael A. , Ashton Nicholas J. , Karikari Thomas K. , Tripodis Yorghos , Martin Brett , Palmisano Joseph N. , Steinberg Eric G. , Simkina Irene , Turk Katherine W. , Budson Andrew E. , O'Connor Maureen K. , Au Rhoda , Goldstein Lee E. , Jun Gyungah R. , Kowall Neil W. , Stein Thor D. , McKee Ann C. , Killiany Ronald , Qiu Wei Qiao , Stern Robert A. , Mez Jesse , Alosco Michael L. 
Published: December 2021

AbstractIntroductionWe examined the ability of plasma hyperphosphorylated tau (p‐tau)181 to detect cognitive impairment due to Alzheimer's disease (AD) independently and in combination with plasma total tau (t‐tau) and neurofilament light (NfL).MethodsPlasma samples were analyzed using the Simoa platform for 235 participants with normal cognition (NC), 181 with mild cognitive impairment due to AD (MCI), and 153 with AD dementia. Statistical approaches included multinomial regression and Gaussian graphical models (GGMs) to assess a network of plasma biomarkers, neuropsychological tests, and demographic variables.ResultsPlasma p‐tau181 discriminated AD dementia from NC, but not MCI, and correlated with dementia severity and worse neuropsychological test performance. Plasma NfL similarly discriminated diagnostic groups. Unlike plasma NfL or t‐tau, p‐tau181 had a direct association with cognitive diagnosis in a bootstrapped GGM.DiscussionThese results support plasma p‐tau181 for the detection of AD dementia and the use of blood‐based biomarkers for optimal disease detection.
Black and White individuals differ in dementia prevalence, risk factors, and symptomatic presentation
Authors: Lennon Jack C. , Aita Stephen L. , Bene Victor A. Del , Rhoads Tasha , Resch Zachary J. , Eloi Janelle M. , Walker Keenan A. 
Published: December 2021

AbstractIntroductionAlthough dementia prevalence differs by race, it remains unclear whether cognition and neuropsychiatric symptom severity differ between Black and White individuals with dementia.MethodsUsing National Alzheimer's Coordinating Center (NACC) data, we evaluated dementia prevalence in non‐Hispanic Black and White participants and compared their clinicodemographic characteristics. We examined race differences in cognition, neuropsychiatric symptoms, and functional abilities in participants with dementia using multivariable linear and logistic regression models.ResultsWe included 5,700 Black and 31,225 White participants across 39 Alzheimer's Disease Research Centers. Of these, 1,528 (27%) Black and 11,267 (36%) White participants had dementia diagnoses. Despite having lower dementia prevalence, risk factors were more prevalent among Black participants. Black participants with dementia showed greater cognitive deficits, neuropsychiatric symptoms/severity, and functional dependence.DiscussionDespite lower dementia prevalence, Black participants with dementia had more dementia risk factors, as well as greater cognitive impairment and neuropsychiatric symptom severity than White participants.
Thermoluminescence glow curve deconvolution and kinetic parameter determination of samarium‐doped lithium borosilicate glass
Authors: Abdelmonem Ahmed , Alazab Huda A. , Salama Elsayed 
Published: December 2021

AbstractThermoluminescence glow curves of gamma‐irradiated samarium‐doped lithium borosilicate glass were investigated. The number of overlapping peaks was determined using the repeated initial rise method. The glow curves were deconvoluted into four overlapping peaks. The trapping parameters such as activation energy E, frequency factor (s), and kinetic order (b) for each peak were determined. The obtained results indicated that the lithium borosilicate glass doped with samarium had four electron trap levels with the average activation energies of 0.82, 1.01, 1.21, and 1.31 eV. Thermal fading analysis of the individual peaks based on the deconvolution data was performed. The obtained results showed high thermal fading of the first peak, but high thermal stability of the second and third peaks compared with the other peaks. These results could be used to explain some observed properties such as high thermal fading and light sensitivity for this thermoluminescent material. Moreover, the obtained results may be helpful in minimizing fading corrections in dosimetric applications.
Chromatographic capture of cells to achieve single stage clarification in recombinant protein purification
Authors: Almeida Aaron , Chau David , Coolidge Thomas , El‐Sabbahy Hani , Hager Steven , Jose Kevin , Nakamura Masa , Voloshin Alexei 
Published: December 2021

AbstractRecent advancements in cell culture engineering have allowed drug manufacturers to achieve higher productivity by driving higher product titers through cell line engineering and high‐cell densities. However, these advancements have shifted the burden to clarification and downstream processing where the difficulties now revolve around removing higher levels of process‐ and product‐related impurities. As a result, a lot of research efforts have turned to developing new approaches and technologies or process optimization to still deliver high quality biological products while controlling cost of goods. Here, we explored the impact of a novel single use technology employing chromatographic principle‐based clarification for a process‐intensified cell line technology. In this study, a 16% economic benefit ($/g) was observed using a single‐use chromatographic clarification compared to traditional single‐use clarification technology by improving the overall product cost through decreased operational complexity, higher loading capacity, increased product recovery, and higher impurity clearance. In the end, the described novel chromatographic approach significantly simplified and enhanced the cell culture fluid harvest unit operation by combining the reduction of insoluble and key soluble contaminants of the harvest fluid into a single stage.
Better effect of intrapleural perfusion with hyperthermic chemotherapy by video‐assisted thoracoscopic surgery for malignant pleural effusion treatment compared to normothermic chemoperfusion of the pleural cavity
Authors: Cao Yejun , Zhang Qiying , Huang Zhiyuan , Chai Zhengjun , Liu Jie , Wang Jinyi , Sun Zhengliang , Zhao Tian , Wang Guangxue , Chen Guohan , Han Yang , Li Qinchuan , Hong Xuan 
Published: December 2021

AbstractObjectiveThe aim of this study was to assess the efficacy and safety of intrapleural perfusion with hyperthermic chemotherapy (IPHC) in treating malignant pleural effusion (MPE) compared to normothermic chemoperfusion of the pleural cavity (NCPC), and to investigate the better treatment to control MPE.MethodsMalignant pleural effusion patients were enrolled in the study and treated with NCPC or IPHC under video‐assisted thoracoscopic surgery (VATS). The chest drainage duration, clinical characteristics, and recurrence time of pleural effusion of patients were collected for statistical analysis. The chi‐squared test and the Fisher's exact test were applied to compare the distribution differences in categorical variables. Progression‐free survival (PFS) was estimated by the Kaplan–Meier method and was compared by the log‐rank test. The survival analysis was performed using the Cox proportional hazards method.ResultsA total of 37 MPE patients were enrolled in this study. Twenty‐seven patients received NCPC and 10 patients received IPHC under VATS. Significant differences were found in pathological types (p = 0.011), chest drainage duration (p = 0.005), and remission rate (p = 0.009) between two different treatment groups. The chest drainage duration of IPHC under VATS was shorter than the NCPC group (t = 2.969, p = 0.005). The remission rate of MPE in IPHC group was better than the NCPC one (OR = 0.031, 95% CI: 0.002–0.507, p = 0.015). The result of the Kaplan–Meier method showed that IPHC group could significantly prolong the PFS of patients with MPE compared to NCPC group (log‐rank p = 0.002). Univariate cox regression analysis showed that patients with MPE in the IPHC group presented significant longer PFS than the NCPC group (HR = 0.264, 95% CI: 0.098–0.713, p = 0.009). Multivariate cox regression analysis further verified this conclusion (HR = 0.268, 95% CI: 0.096–0.753, p = 0.012).ConclusionCompared to the NCPC, the IPHC under VATS presents a better control effect on MPE, shorter tube placement time, and longer complete remission time. For this reason, we recommend IPHC under VATS as the first‐line treatment for patients with MPE those who can tolerate minimally invasive surgery.
Relationships between present/future orientation and life satisfaction over two decades
Authors: Joshanloo Mohsen 
Published: December 2021

AbstractThis study sought to explore the relationships between present orientation (i.e., endorsing a live‐for‐today approach), future orientation (i.e., valuing planning for the future) and life satisfaction over two decades. A sample of American adults (N = 6,464) across three waves was used. The temporal within‐person associations between the variables were examined using the random‐intercept cross‐lagged panel model. Participants who reported higher present orientation also reported lower life satisfaction in the future. Although it is often assumed that future orientation leads to higher future well‐being, the present results demonstrated that higher life satisfaction prospectively predicted future orientation, and not the other way around. The longitudinal trajectories of the variables were also examined using latent growth curve modeling. The results indicated that life satisfaction remained stable, present orientation increased and future orientation decreased over the course of the study. Overall, life satisfaction exhibited greater temporal stability than time orientation.
Acute transverse myelitis revealing ankylosing spondylitis: A case report and literature review
Authors: Boussaid Soumaya , Rahmouni Safa , Rekik Sonia , Jammali Samia , Cheour Elhem , Sahli Hela , Elleuch Mohamed 
Published: December 2021

AbstractWhen faced with a patient with acute myelopathy, thorough investigations should be undertaken to determine the cause. Ankylosing spondylitis should be kept in mind as a possible cause.
Development of α‐MnO2 Nanowire with Ni‐ and (Ni, Co)‐Cation Doping as an Efficient Bifunctional Oxygen Evolution and Oxygen Reduction Reaction Catalyst
Authors: Selvakumar Karuppiah , Duraisamy Velu , Venkateshwaran Selvaraj , Arumugam Natarajan , Almansour Abdulrahman I. , Wang Yucheng , Xiaoteng Liu Terence , Murugesan Senthil Kumar Sakkarapalayam 
Published: December 2021

AbstractManganese oxides (MnO2) with nanowire morphology materials are promising candidates for improving oxygen evolution and oxygen reduction reaction (OER/ORR) performance. In this work, we developed transition metal cation doping strategy into the α‐MnO2 tunnel structure to tune the Mn oxidation states and control the uniform nanowire morphology, crystalline structure to investigate the effect of doping over bifunctional activity. The single Ni2+ cation doping in α‐MnO2 with various loading concentrations resulted in 8Ni−MnO2 exhibiting remarkable OER and ORR activity owing to their excessive concentration of Mn3+ and Mn4+ octahedral sites respectively. Further, Co2+ cation doping in 8Ni−MnO2 leads to an enhanced synergistic effect that significantly improves the fraction of Mn3+ quantity which is confirmed by average oxidation state. For electrochemical OER performance, 8Co−8Ni−MnO2 exhibits a potential of 1.77 V, Tafel slope value of 68 mV dec−1 and lower charge transfer resistance and it is active in ORR with more positive onset potential of 0.90 V, half‐wave potential of 0.80 V, better current density (4.7 mA cm−2) and a four‐electron pathway. Moreover, bifunctional activity (ΔE=EOER@10 mA cm−2 – ORR@E1/2) of 8Co−8Ni−MnO2 demonstrated 0.97 V, indicates an excellent activity in alkaline electrolyte solution.
Staubexplosionen verhindern
Authors: Schlüter Kai 
Published: December 2021

Abstractie TRGS 727 ist als Grundlage für die Vermeidung von Zündquellen aufgrund elektrostatischer Aufladungen in Deutschland übergreifend anerkannt und wird daher in der Praxis häufig als Grundlage für die betriebliche Vorgehensweise genutzt. In ausführlichen Beschreibungen, Arbeitsanweisungen und Rechenbeispielen werden die Entstehung elektrostatischer Aufladung in industriellen Prozessen beleuchtet, die Gefahren elektrostatischer Entladungen
Mehr Kraft, Ausdauer und Sicherheit
Authors: Rössing Sönke 
Published: December 2021

AbstractIn der Rehabilitationsmedizin kommen Exoskelette schon lange Zeit erfolgreich zum Einsatz. Als den Körper anliegende mechanische Strukturen stabilisieren und entlasten sie sowohl Gliedmaßen als auch den Rumpf. Inzwischen verbreiten sich diese Assistenzsysteme auch im industriellen Umfeld.
Kolonnenfüllkörper reinigen
Authors: Günther Sabine 
Published: December 2021

AbstractUm die Oberfläche in Kolonnen petrochemischer Anlagen zu vergrößern, werden Füllkörper eingesetzt. Diese Edelstahlringe müssen von Zeit zu Zeit von Korrosion und Ablagerungen befreit werden. Bei der Entnahme der Füllkörper ist auf eine strikte Trennung der einzelnen Formen der Edelstrahlringe zu achten und diese auch bei der Wiederbefüllung korrekt einzuhalten. Für die Reinigung kommt eine Spezialwaschmaschine von Lobbe zum Einsatz.
O‐Ringe unter der Lupe
Authors: Krüger Michael 
Published: December 2021

AbstractDie meistverbaute Dichtung, der O‐Ring, soll zuverlässig seine Dichtfunktion erfüllen. Hierfür steht dem Anwender eine Vielzahl unterschiedlicher Werkstoffe zur Verfügung, die auf die jeweiligen Anwendungsbedingungen abgestimmt sein müssen. Trotz scheinbar richtiger Werkstoffwahl, kann es nach einer kurzen Betriebszeit zu einer unerwarteten Leckage kommen.
Fast 1.450 t weniger CO2‐Ausstoß pro Jahr
Authors: Preuß Thomas 
Published: December 2021

AbstractMit drei neuen Turbokompressoren spart der Chemiekonzern OQ Chemicals in Oberhausen jährlich etwa zwei Millionen Kilowattstunden Strom ein – etwa 20% im Vergleich zum Energiebedarf der alten Druckluftversorgung. Zudem wurde der CO2‐Fußabdruck um rund 1450 t/a reduziert. Dazu tragen auch die drei Drehtrommeltrockner bei, die das Trockenmittel höchst effizient mit der im Verdichtungsprozess entstehenden Wärme regenerieren.CO2‐Fußabdruck um rund 1450 Tonnen pro Jahr reduziert. Dazu tragen auch die drei Drehtrommeltrockner bei, die das Trockenmittel höchst effizient mit der im Verdichtungsprozess entstehenden Wärme regenerieren.
Verschleiäfrei dicht dank Fliehkraft
Authors: Walz Sandra 
Published: December 2021

AbstractDie Dichtheit von berührungslosen Labyrinthdichtungen basiert auf der Fliehkraft, welche die eingedrungenen Schmierstoffe, Flüssigkeiten und Stäube durch die Konstruktion wieder zurück ins System bzw. nach außen führt. Sie eignen sich besonders für den Einsatz in rotierenden Anlagen, die in einer rauen Umgebung arbeiten. Auch Anforderungen wie hohe Drehzahlen, Korrosionsbeständigkeit, Sperrluftintegration, ATEX‐Eignung oder Lagerstromschutz können mit dem Dichtungskonzept abgedeckt werden.
Pumpenüberwachung in Echtzeit
Authors: Bonafede Claudio 
Published: December 2021

AbstractDer Schweizer Maschinenbauer Maag ergänzt sein Industriepumpenportfolio um die Dosierpumpenreihe DX 14, die auch für neue, noch anspruchsvollere Prozesse wie Aromenproduktion oder Destillation geeignet ist.
Trockene Druckluft mit hohen Volumenströmen
Authors: Rockmann Ina 
Published: December 2021

AbstractWo feinchemische oder pharmazeutische Produkte in hohen Auflagen hergestellt werden, ist der Schutz vor Verunreinigungen und Feuchte besonders wichtig. Das gilt über die gesamte Prozesskette hinweg – und somit auch für die Drucklufterzeugung. Der Druckluftspezialist Boge stattet seine Anlagen dafür mit warmregenerierten Adsorptionstrocknern aus.
Schall und Schaum
Authors: Sacher Jörg 
Published: December 2021

AbstractDampf ist in vielen Bereichen der Industrie ein unverzichtbares Arbeitsmittel. Im Bemühen um die möglichst effiziente Nutzung der wertvollen Ressource gewinnt die genaue Messung von Verbräuchen mehr und mehr an Bedeutung. Wie aber lassen sich die in den nur wenige Sekunden dauernden Aufschäumprozessen von expandierbarem Polystyrol eingesetzten Dampfmengen exakt erfassen? Bei dem Anbieter von Partikelschaumanlagen Erlenbach in Lautert kommt dazu ein Ultraschall‐Durchflussmesser zum Einsatz.
Partikelgrößen inline messen
Authors: Schäble Pia 
Published: December 2021

AbstractDie Qualität vieler End‐ und Zwischenprodukte in Chemie, Pharma und Food wird bisher durch aufwändige Laboranalysen festgestellt. Die Produktqualität wird so lediglich nachträglich bewertet. Das bringt große zeitliche Verzögerungen bei der Freigabe von produzierten Chargen mit sich und kann zur Produktion von off‐spec‐Material führen, ohne dass es während der Fertigung bemerkt wird. Die Vorteile kontinuierlicher Produktionsverfahren kann man dadurch nicht vollständig ausnutzen.
Silica Nanowires Reinforced with Poly(vinylidene fluoride‐co‐hexafluoropropylene): Separator for High‐Performance Lithium Batteries
Authors: Du Qingchuan , Shi Shumin , Zhang Lida , Yan Zhongyuan , Zeng Xu , Wu Jingjing , Zhou Weixin , Huang Zhen‐Dong , Masese Titus , Ma Yanwen 
Published: December 2021

AbstractSeparators are key components that physically separate and chemically connect the anode and cathode to guarantee the safety and cycle stability of batteries. Herein, based on the building concept of a bird's nest, we have developed separators comprising SiO2 nanowires reinforced with poly(vinylidene fluoride‐co‐hexafluoropropylene) (PVDF‐HFP). In particular, the hybrid separators with 39% of PVDF‐HFP exhibit much enhanced tensile strength, Young's moduli, flexibility, and elongation as a result of a strong crosslink effect, compared to bare SiO2 nanowire separator, while yet maintaining excellent electrolyte wettability, high ionic conductivity, and wide electrochemical window. Moreover, the hybrid separators also demonstrate excellent thermal stability and dendrite suppression capability. Lithium metal batteries assembled using the hybrid separators with LiFePO4 as the cathode achieve excellent rate performance and cyclic stability. The discharge capacities attained at a current density equivalent to 0.2 C and 2 C rate are 157 and 126 mAh g−1, respectively. A capacity of 99 mAh g−1 is still maintained at 2 C rate after 500 cycles. This study illuminates SiO2 nanowires reinforced with PVDF‐HFP as promising separators for high‐energy, high‐power and safe lithium batteries.
Price forecasting for real estate using machine learning: A case study on Riyadh city
Authors: Louati Ali , Lahyani Rahma , Aldaej Abdulaziz , Aldumaykhi Abdullah , Otai Saad 
Published: December 2021

AbstractReal estate is potentially contributing to the economic growth. It has a strong correlation between property owners and beneficiaries. The accurate forecast of future property prices is particularly important. Therefore, real estate prices are reflecting the economic level of counties, and their price ranges are of great interest to both buyers and sellers. Developing a land‐price forecast model could significantly assist in predicting future land prices and setting real estate regulations. In contrast, machine learning (ML) algorithms have demonstrated a great potential to perform predictions. Motivated by these assumptions, we develop in this article a set of ML algorithms to build models capable to increase the effectiveness of land price estimation. The ML algorithms adopted in this work include the decision tree, random forest (RF), and linear regression. We collected data from 5946 lands localized in the northern area of Riyadh, KSA. This data has been collected using GeoTech's DAAL website. The performance of the developed models has been assessed based on state‐of‐art performance metrics including mean absolute error, mean squared error, and median squared error. The experiments show that the RF based model outperforms the remaining models.
Detection of cytogenetic changes and chromosomal aneuploidy with fluorescent in situ hybridization in cytological specimens of oral cancers in Fanconi anemia—Proof of concept
Authors: Silva de Araujo Bruno Eduardo , Velleuer Eunike , Dietrich Ralf , Pomjanski Natalia , de Santana Almeida Araujo Isabela Karoline , Schlensog Martin , Wells Susanne Irmtraud , Dorsman Josephine Christine , Schramm Martin 
Published: December 2021

AbstractObjectivesFanconi anemia (FA) is a rare inherited DNA instability disorder with a remarkably elevated risk of neoplasia compared with the general population, mainly leukemia and squamous cell carcinoma (SCC). Two thirds of the SCCs arise in the oral cavity and are typically preceded by visible lesions. These lesions can be classified with brush biopsy‐based cytological methods regarding their risk of a malignant transformation. As a proof of concept, this study aims to investigate genetic changes and chromosomal aneuploidy using fluorescent in situ hybridization (FISH) on oral squamous cells derived from FA affected individuals.Material and MethodsFive FA oral SCC (OSCC) tumor cell lines, one FA OSCC cervical lymph node metastasis as well as tumor‐negative and atypical smears from oral brush biopsies were analyzed with FISH probes covering 5p15.2, MYC, EGFR, TERC, 9q34.1, CCND1, 9p21 and centromeres of chromosomes 3, 6, 7, 9, 11, and 17.ResultsOSCC specimens showed gains of all analyzed chromosomal regions. Chromosomal aneuploidy was observed in five of the six OSCC specimens in two multicolor FISH assays with panels of four probes each. Five out of six OSCC specimens displayed a relative deletion of 9p21. Applied on atypical brush biopsy‐based smears, chromosomal aneuploidy was detected in malignant lesions but not in the smear derived from a severe parodontitis.ConclusionsAs proof of concept, FISH was able to detect genetic changes and chromosomal aneuploidy discriminating oral cancer from noncancerous lesions in individuals with FA. This supports its application on oral brush biopsy‐based cytology.
Energy‐efficient fog computing in Internet of Things based on Routing Protocol for Low‐Power and Lossy Network with Contiki
Authors: Kumar Arun , Sharma Sharad , Goyal Nitin , Gupta Sachin Kumar , Kumari Saru , Kumar Sachin 
Published: December 2021

SummaryThe traditional centralized cloud computing (CC) model faces a range of problems with the exponential growth of the Internet of Things (IoT) applications, like high latency, reduced bandwidth, and network instability. Fog computing (FC) takes the cloud closer to IoT computers to overcome these problems. Rather than moving them to the cloud, the FC provides local IoT data processing and storage on IoT computers. This paper focuses on the Routing Protocol for Low‐Power and Lossy Network (RPL), a universally routing protocol for a static environment that is used for reducing energy consumption, delay, and packet loss with data aggregation at the border router using a fog simulation model in Contiki Cooja. The objective function (OF) choice has an impact on network topology, as each node selects a set of potential parents to send to the destination. However, no systematic analysis of the effects of OF behavior in the RPL environment has been undertaken. Here, three different OFs, Objective Function Zero (OF0), Advanced Objective Function Zero (AOF0), and Minimum Rank with Hysteresis Objective Function (MRHOF) for RPL in the static environment for different node numbers, have been compared. The findings demonstrate that altering all three OFs has a significant impact on RPL. The energy consumption is reduced in the case of the AOF0 in the fog node by 50.86%, which is less than the case of the OF0 and MRHOF function. Extensive simulations show that AOF0 outperforms the existing OFs.