bluuebunny/crossref_metadata_2025_split huggingface dataset:
Negative-pressure hydrocephalus in the course of a complex postoperative intracranial pressure disturbance: illustrative case
Authors: Suzuki Tomoya , Kaku Shogo , Karagiozov Kostadin , Murayama Yuichi 
Published: January 2021

BACKGROUNDNegative-pressure hydrocephalus (NePH) is a rare clinical entity that presents on the background of ventriculomegaly with atypical symptoms. Its diagnosis is difficult, and some patients experience several shunt revisions until the proper solution is found.OBSERVATIONSThe authors present a patient who developed acute deterioration due to iatrogenic NePH after surgery for a vertebral artery thrombosed giant aneurysm. The deterioration occurred after the insertion of a lumbar drain by which the authors intended to reduce a postoperative subcutaneous cerebrospinal fluid (CSF) collection. The drainage created an unexpected negative-pressure gradient in the CSF spaces, which resulted in NePH. Interventions, such as extraventricular drainage and blood patch, corrected the negative transmantle pressure and stabilized the patient’s condition.LESSONSBecause the pathophysiology of NePH is theoretically considered to be caused by negative transmantle pressure, the intervention should be performed in order to deal with the coexistence of obstruction in the CSF pathways and a CSF leak. A blood patch would be an effective option in treating the CSF leak when the site of leakage is certain. This is the first case in which a blood patch was effectively applied in the treatment for NePH with a favorable outcome without any permanent CSF diversion.
Utility of Pipeline embolization device for emergency recanalization of a dissecting carotid tonsillar loop: illustrative cases
Authors: Akamatsu Yosuke , Gomez-Paz Santiago , Moore Justin M. , Ogilvy Christopher S. , Thomas Ajith J. 
Published: January 2021

BACKGROUNDCervical arterial tortuosity is not uncommon in patients with spontaneous carotid artery dissections (CADs), but the tortuosity often precludes endovascular stent reconstruction. The authors report 2 cases of emergency recanalization of a carotid tonsillar loop dissection using a Pipeline embolization device (PED).OBSERVATIONSTwo patients presented with symptomatic CAD involving tonsillar looping of the cervical internal carotid artery (ICA). Although the tonsillar loop prevented navigation of the carotid and peripheral stent delivery system, a PED was easily navigated and successfully deployed, resulting in successful recanalization of a looped ICA.LESSONSEmergency recanalization of a cervical CAD using a PED is a feasible alternative for treating a cervical CAD associated with tonsillar loops.
Simultaneous intracranial and testicular germ cell tumors: illustrative case
Authors: Han Lei , Lu Jie , Fang Luxiong , Qi Songtao , Song Ye 
Published: January 2021

BACKGROUNDSimultaneous intracranial and testicular germ cell tumors (GCTs) are extremely rare, leading to a lack of adequate experience in their treatment. Therefore, the authors report a case of this kind of GCT.OBSERVATIONSA 5-year-old boy was admitted to the hospital with headache and vomiting. Computed tomography and magnetic resonance imaging suggested the possibility of a GCT in the pineal region. The value of the serum tumor marker alpha-fetoprotein (AFP) was 5,396.1 μg/L, and β-human chorionic gonadotropin levels were within the normal range. Subsequently, the tumor was removed, and the final pathological result was a mixed GCT. Therefore, chemotherapy and radiation were added. However, the authors found a testicular tumor on ultrasound at the same time, and pathology after surgery suggested a mature cystic teratoma. Following treatment, the patient recovered well, and AFP levels dropped to normal values.LESSONSTo the authors’ knowledge, this report is the fourth case of simultaneous intracranial and testicular GCTs and the first case of a simultaneous mixed GCT in the pineal region and mature teratoma of the testis. A combination of surgery, chemotherapy, and radiation therapy for mixed GCTs in the pineal region and surgical excision for testicular reproductive cell tumors are effective in these patients, but long-term monitoring is required.
Functional neurological disorders in patients undergoing spinal surgery: illustrative case
Authors: Yerneni Ketan , Wadhwa Harsh , Fatemi Parastou , Zygourakis Corinna C. 
Published: January 2021

BACKGROUND“Conversion disorder” refers to bodily dysfunction characterized by either sensory or motor neurological symptoms that are unexplainable by a medical condition. Given their somatosensory context, such disorders often require extensive medical evaluation, and the diagnosis can only be made after structural disease is excluded or fails to account for the severity and/or spectrum of the patient’s deficits.OBSERVATIONSThe authors briefly review functional psychiatric disorders and discuss the comprehensive workup of a patient with a functional postoperative neurological deficit, drawing from their recent experience with a patient who presented with conversion disorder immediately after undergoing anterior cervical discectomy and fusion.LESSONSConversion disorder has been found to be associated with bodily stress, requiring surgeons to be aware of this condition in the postoperative setting. This is especially true in neurosurgery, given the overlap of true neurological pathology, postoperative complications, and manifestations of conversion disorder. Although accurately diagnosing and managing patients with conversion disorder remains challenging, an understanding of the multifactorial nature of its etiology can help clinicians develop a methodical approach to this condition.
Acute pulmonary edema due to occult air embolism detected on an automated anesthesia record: illustrative case
Authors: Wood Samuel , Fuzaylov Gennadiy 
Published: January 2021

BACKGROUNDThe authors report a case of venous air embolism (VAE) during a pediatric posterior fossa craniotomy with resulting pulmonary edema requiring postoperative ventilation. Pulmonary edema is a known but rare complication of VAE, and diagnosis and treatment are discussed.OBSERVATIONSThe embolism was undetected during the surgical procedure, and the first clinical sign of respiratory decompensation appeared an hour after the initial insult, with imaging suggesting acute pulmonary edema. A transient but significant end-tidal carbon dioxide decrease was detected on postoperative review of the anesthesiology record.LESSONSThis report highlights an uncommon sequela of VAE and the importance of post hoc automated record review for intraoperative event analysis.
Asymptomatic rotational vertebral artery compression in a child due to head positioning for cranial surgery: illustrative case
Authors: Caton M. Travis , Narsinh Kazim , Baker Amanda , Abla Adib A. , Roland Jarod L. , Halbach Van V. , Fox Christine K. , Fullerton Heather J. , Hetts Steven W. 
Published: January 2021

BACKGROUNDThe authors recently reported a series of children with vertebral artery (VA) compression during head turning who presented with recurrent posterior circulation stroke. Whether VA compression occurs during head positioning for cranial surgery is unknown.OBSERVATIONSThe authors report a case of a child with incidental rotational occlusion of the VA observed during surgical head positioning for treatment of an intracranial arteriovenous fistula. Intraoperative angiography showed dynamic V3 occlusion at the level of C2 with distal reconstitution via a muscular branch “jump” collateral, supplying reduced flow to the V4 segment. She had no clinical history or imaging suggesting acute or prior stroke. Sequential postoperative magnetic resonance imaging scans demonstrated signal abnormality of the left rectus capitus muscle, suggesting ischemic edema.LESSONSThis report demonstrates that rotational VA compression during neurosurgical head positioning can occur in children but may be asymptomatic due to the presence of muscular VA–VA “jump” collaterals and contralateral VA flow. Although unilateral VA compression may be tolerated by children with codominant VAs, diligence when rotating the head away from a dominant VA is prudent during patient positioning to avoid posterior circulation ischemia or thromboembolism.
A case of brain metastasis with pathological transformation of long-surviving malignant pleural mesothelioma: illustrative case
Authors: Noda Ryuichi , Yanagisawa Shunsuke , Inoue Masato , Hara Tetsuo 
Published: January 2021

BACKGROUNDMalignant pleural mesothelioma (MPM) is a rare cancer, and in 80% of cases the cause is asbestos exposure. In 1972, the World Health Organization (WHO) declared asbestos is a carcinogenic substance. Since then, every developed country has restricted and banned the product. Because of its high heat resistance, asbestos had been widely used as building material for decades. The WHO estimated that approximately 125 million people are exposed to asbestos, and more than 107,000 die from asbestos-related diseases annually. Because of its long incubation period, the number of patients is estimated to keep increasing in the near future.OBSERVATIONSThe authors report a case of long-surviving MPM with a rushed clinical course after brain metastasis. A 69-year-old woman diagnosed with MPM (epithelial type) 6 years earlier presented with a brain metastasis. The pathological result of the brain metastasis was the sarcomatoid type. This case showed the possibility of subtype transition after long survival.LESSONSThis article aids in understanding the long-term natural history of MPM and the possibility of epithelial-mesenchymal transition. Neurosurgeons have to be aware of its the natural history and the possibility of brain metastasis.
Pengaruh Polivinilpirolidon sebagai Polimer Mukoadhesif terhadap Sifat Fisik Patch Ekstrak Kulit Buah Delima (Punica granatum L.)
Authors: Wahid Rahmat A Hi 
Published: January 2021

ABSTRAKBuah delima (Punica granatum L.) secara empiris digunakan untuk mengobati masalah gigi dan mulut seperti sariawan. Pengembangan obat sariawan berbasis herbal dengan bentuk sediaan patch dilakukan untuk mempertahankan waktu kontak antara zat aktif dengan bagian sariawan. Polivinilpirolidon (PVP) digunakan sebagai polimer karena sifatnya mukoadhesif sehingga mampu berikatan pada mukosa mulut. Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan PVP sebagai polimer mukoadhesif terhadap karakteristik fisik sediaan patch yang mengandung ekstrak kulit buah delima (EKBD). EKBD diperoleh dengan metode maserasi. Konsentrasi EKBD yang digunakan adalah 5% dan 10%. Sedangkan konsentrasi polimer PVP yang digunakan yaitu 30,29%, 33,04, 48,75%, dan 65,5%. Patch selanjutnya akan di evaluasi fisik yang meliputi keseragaman bobot dan dimensi ketebalan, pH permukaan, swelling, daya lekat, dan waktu lekat. Hasil menunjukkan bahwa patch yang mengandung ekstrak 10% dengan tambahan polimer konsentrasi 30,29% memiliki sifat yang cukup elastis disbanding dengan konsentrasi 48,75% dan 65,5%. Sedangkan uji evaluasi fisik menghasilkan keseragaman bobot dan dimensi yang seragam, pH 6,63, rata-rata indeks swelling 40,69% ± 16, dan rata-rata daya dan waktu lekat 13,50 ± 11,6. Dengan demikian dapat disimpulkan bahwa konsentrasi PVP terbukti berpengaruh pada sifat fisik patch yang dihasilkan. Kata kunci : Polivinilpirolidon; Ekstrak Kulit Buah Delima; Patch.ABSTRACTPomegranate (Punica granatum L.) is empirically used to treat dental and mouth problems such as reccurent aphthous stomatitis (RAS). The development of RAS therapy based on herbal with patches dosage forms is carried out to maintain the contact time between the active substance and the RAS. Polyvinylpyrrolidone (PVP) is used as a polymer because it is mucoadhesive, so it can bind to the oral mucosa. Aimed to determine the effect of the use of PVP as a mucoadhesive polymer on the physical characteristics of patches preparations containing pomegranate peel extract (PPE). PPE was obtained by maceration method. The PPE concentration used were 5% and 10%. PVP concentration used were 30.29%, 33.04%, 48.75%, and 65.5%. The patches properties such as uniformity of thickness, pH, swelling index, tensile and mucoadhesive strength. The results showed that patches containing 10% extract and PVP concentration of 30.29% had sufficient elastic properties compared to both concentration. While the physical evaluation test obtained uniform weights and dimensions that are uniform, pH 6.63, the average swelling index is 40.69% ± 16, and the tensile and mucoadhesive strength is 13.50 ± 11.6. Altogether, the concentration of PVP is proven to affect the physical properties of the resulting patch.Key word : Polyvinylpyrrolidone; Pomegranate Peel Extract; Patch.
Evaluasi Penerapan Standar Pelayanan Kefarmasian di Puskesmas Tanjung Karang
Authors: Oktaviani Nur 
Published: January 2021

ABSTRAKPelayanan kefarmasian di puskesmas merupakan satu kesatuan yang tidak terpisahkan dari pelaksanaan upaya kesehatan yang berperan penting dalam meningkatkan mutu pelayanan kesehatan bagi masyarakat, khususnya di bidang kefarmasian Penelitian ini bertujuan untuk mengetahui evaluasi penerapan standar pelayanan kefarmasian di Puskesmas Tanjung Karang. Penelitian ini termasuk penelitian deskriptif, pengambilan data dengan menggunakan pendekatan cross sectional, instrumen dalam penelitian ini adalah kuesioner yang bersumber dari Peraturan Menteri Kesehatan No 74 Tahun 2016 tentang standar pelayanan kefarmasian di Puskesmas. Responden dalam penelitian ini adalah petugas farmasi dan pasien rawat jalan di puskesmas Tanjung Karang. Hasil penelitian yaitu kegiatan pengelolaan obat dan bahan medis habis pakai sebesar 90%, Peralatan dan fasilitas pendukung sebesar 87,5%, pelayanan informasi obat sebesar 100%, dan sumber daya manusia sebesar 100%.Yang menunjukkan bahwa evaluasi penerapan standar pelayanan kefarmasian di Puskesmas Tanjung Karang berdasarkan Indikator-Indikator pelayanan farmasi sudah di laksanakan dengan baik dengan nilai rata-rata sebesar 94,37%.Kata kunci : Evaluasi; Pelayanan Kefarmasian; Puskesmas Tanjung Karang.ABTRACT :Pharmaceutical services in health centers are an integral part of the implementation of health efforts that play an important role in improving the quality of health services for the community, especially in the field of pharmacy. This study aims to determine the evaluation of the implementation of pharmaceutical service standards at the Tanjung Karang Puskesmas. This research is a descriptive study, data collection using a cross-sectional approach, the instrument in this study is a questionnaire which is sourced from the Minister of Health Regulation No. 74 of 2016 concerning the standard of pharmaceutical services at Puskesmas. Respondents in this study were pharmacy officers and outpatients at Tanjung Karang Public Health Center. The results of the study were the management of drugs and consumable medical materials by 90%, equipment and supporting facilities at 87.5%, drug information services at 100%, and human resources at 100%, which showed that the evaluation of the implementation of pharmaceutical service standards at the Puskesmas Tanjung Karang based on indicators of pharmaceutical services has been implemented well with an average value of 94.37%.Keywords : Evaluation; Pharmaceutical Services; Puskesmas Tanjung Karang.
Penetapan Kadar Fenolik Total Ekstrak Kacang Panjang (Vigna unguiculata) dengan Metode Spektrofotometri UV-Visible
Authors: Dewantara Lalu Aang Robby , Ananto Agus Dwi , Andayani Yayuk 
Published: January 2021

ABSTRAKKacang panjang (Vigna unguiculata) merupakan salah satu tanaman yang berpotensi sebagai antioksidan karena mengandung metabolit sekunder hampir di seluruh bagian tanamannya, seperti pada daging buahnya. Penelitian ini bertujuan untuk menentukan kadar fenolik total ekstrak etanol dan ekstrak air daging buah kacang panjang dengan metode spektrofotometri UV-Visible. Sampel daging buah kacang panjang dimaserasi menggunakan dua pelarut berbeda, yaitu pelarut etanol 96% dan pelarut air. Analisis kadar fenolik total dilakukan dengan metode spektrofotometri UV-Visible. Kadar fenolik total dinyatakan dalam gallic acid equivalent (GAE). Hasil analisis menunjukkan bahwa kadar fenolik total ekstrak etanol kacang panjang sebesar 40,4173 ± 4.2303 mg GAE/g dan kadar fenolik total ekstrak air kacang panjang sebesar 60.6062 ± 2,8533 mg GAE/g. Ekstrak etanol dan ekstrak air dari daging buah kacang panjang berpotensi sebagai antioksidan dilihat dari parameter kadar fenolik totalnya. Berdasarkan hasil penelitian, diperoleh bahwa kadar fenolik total ekstrak air lebih tinggi dibandingkan ekstrak etanol daging buah kacang panjang. Kata kunci : Kacang panjang (Vigna unguiculata); Spektrofotometri UV-Visible; Kadar fenolik total.ABSTRACTCowpea (Vigna unguiculata) is one of the vegetables that have antioxidant potential due to it contains some secondary metabolites that scattered on every part of the Cowpea, such as the pod coat. The aimed of this study was to determine total phenolic content of Cowpea pod coat ethanolic extract and aqueous extract using UV-Vis spectrophotometry method. Cowpea pod coats were macerated using two different solvents, ethanol 96%, and aqueous. Total phenolic content was showed as gallic acid equivalent (GAE). The analysis results showed that total phenolic content of ethanol extract of cowpea was 40,41732 ± 4.2303 mg GAE/g and total phenolic content of aqueous extract of cowpea was 60.6062 ± 2,8533 mg GAE/g. The ethanolic extract and aqueous extract of cowpea pod coat have antioxidant potential in terms of total phenolic content parameter. Based on the research, the total phenolic content of cowpea pod aqueous extract higher than cowpea pod coat ethanolic extract.Keywords : Cowpea (Vigna unguiculata); Spectrophotometric UV-Visible; Total phenolic content.
PERSEPSI MASYARAKAT TERHADAP KEBUTUHAN PELAYANAN RUMAH SAKIT SYARIAH DI KOTA YOGYAKARTA
Authors: Rochana Ruliyandari  
Published: January 2021

Rumah sakit syariah merupakan rumah sakit yang dalam aktifitasnya atau pengoperasionalannya berdasarkan pada maqashid syariah. Rumah sakit syariah dibuat dengan standart, sistem dan mutu yang sesuai dengan syariat islam. Penelitian ini dilakukan pada masyarakat kota Yogyakarta. Dengan tujuan untuk melihat kebutuhan masyarakat terhadap rumah sakit syariah. Penelitian ini menggunakan metode deskriptif analitik, dengan teknik pengambilan sampel menggunakan random sampling dengan jumlah sampel sebanyak 43 orang. Data penelitian ini diambil menggunakan kuesioner elektronik. Analisis data dilakukan menggunakan analisis deskriptif. masyarakat sebagian besar setuju bahwa rumah sakit telah melaksanakan prinsip-prinsip syariat islam dalam melakukan pelayanan kesehatan pada pasien. Melakukan pelayanan sesuai gender pasien, berinteraksi dan memiliki prinsip sosial, memiliki lingkungan yang nyaman sesuai syariat islam. Sebagian besar perlu terus menyesuaikan update pelayanan kesehatan yang berbasis syariah, sehingga meningkatkan kepuasan pasien.
Kata Kunci: Pelayanan Kesehatan, Rumah Sakit Syariah, Standar Rumah Sakit Syariah
Authors: Fathony Doohan Ryan , Ramadhani Sulthan Alif Secca , Poetra Vincentian Michael Anton , Rakhmawati Nur Aini 
Published: January 2021

Pada zaman yang serba digital ini, hampir semua orang mempunyai akses internet untuk mememenuhi masing-masing kebutuhannya. Dengan adanya internet segala sesuatu hal informasi dapat diakses dengan mudah dan cepat. Penelitian ini dilakukan dengan tujuan untuk melihat adanya hubungan dari sekolah daring yang memberikan kebebasan dan kemudahan akses internet di rumah dengan meningkatnya pemain game online. Peneltitan dilakukan dengan menyebar kuisioner kepada siswa-siswi SMA di Indonesia, lalu data diolah sedemikian mungkin untuk diidentifikasi perilaku siswa-siswi SMA. Hasilnya didapat terdapat beberapa tanda di mana adanya pengaruh dari sekolah daring dari rumah dengan meningkatnya pemain game online.
The Technology Education System Staffing: Problems and Solutions
Authors: Danilaev D. P. , Malivanov N. N. 
Published: January 2021

The strategic objective of modern technological education is to prepare children for life in a high-tech competitive world. The implementation of this task encounters the problems of material and technical equipment of educational institutions and their staffing. An integrated approach based on the pooling of all resources and efforts of interested parties is needed to organize a technological education modern system. Training programs for teachers should take into account their interdisciplinary nature, and include the psychological, pedagogical, and natural-science components, so as technical aspects. The important segment of technology education is training of technical specialists without pedagogical background to work at schools and universities, as well as training of school teachers and university lectures based on the modern technological order. In this regard, a new look at the IGIP programs is possible, these program goals and objectives interpretation should be applied to the teacher training within the system of high-school technological education.The article considers the approaches to solving the problems of high-school technological education system staffing, presents the comparative analysis of the current educational programs. The experience in training technical university teachers, masters of industrial instruction, technology teachers should be adjusted in accordance with the global changes in science, technique and technology.
Association of hemoglobin and spontaneous closure of the ductus arteriosus during the transitional period in very low birth weight infants
Authors: Joye S. , McNamara P.J. , Giesinger R.E. , Tolsa J-F. , Sekarski N. 
Published: January 2021

OBJECTIVES: To determine the association between plasma hemoglobin (HB) at three time-points (birth, postnatal days 0–3 and 0–10) and spontaneous closure of the ductus arteriosus (sDAC). STUDY DESIGN: A retrospective case-control study of preterm infants born (2013–2016) between 24 and 29 weeks of gestational age (GA) was conducted in a level three perinatal center in Switzerland. We collected hemoglobin at birth, between days 0–3 and 0–10 in two distinct groups: (i) patients treated for a PDA and (ii) patients with spontaneous closure of the ductus arteriosus (sDAC). Antenatal and postnatal demographic data and neonatal morbidity were collected. Bivariate analysis was performed and a stepwise logistic regression was done to investigate factors associated with sDAC. RESULTS: We reviewed the medical chart of 184 premature infants of whom 146 (79.3%) satisfied eligibility criteria. Of these, 74 (51%) were classified as sDAC. Patients with sDAC were older (GA: 28 vs 27, p < 0.001), more stable (clinical risk index for babies score (CRIB score): 2 vs 5, p < 0.001) and had better clinical outcomes than patients who received treatment for a PDA. Infants in the sDAC group had a higher level of hemoglobin during the first ten postnatal days. Multiple logistic regression analysis revealed that lower HB level (day 0–10) were associated with failure of sDAC ( p < 0.05). CONCLUSIONS: This is one of the first studies to highlight a potential association between hemoglobin during the transitional period and sDAC. The biological nature of this observation requires prospective clarification.