bluuebunny/crossref_metadata_2025_split huggingface dataset:
Balanced Fertilization for Improved Nutrient use Efficiency and Mulberry Productivity
Authors: Rajendran Mahesh , Lalremruati Melissa , Chattopadhay Soumen , Vankadara Sivaprasad 
Published: October 2021

Aim: To study the effects of balanced fertilization in improving leaf yield, quality and nutrient use efficiency in mulberry.
Study Design: Experiment was conducted in randomized block design (RBD) consisting of 7 treatments in 3 replications.
Place and Duration of Study: The present study was conducted at Central Sericultural Research and Training Institute, Berhampore ((Latitude 24º05ʹN & Longitude 88º15ʹE; 18 m > MSL), West Bengal, India in two seasons during 2018 (July-August; September-October).
Methodology: Existing S-1635 mulberry plantation (10year-old; 60 cm × 60 cm spacing; net plot area: 32 m2) was utilized. Experiments were conducted in two seasons (July-August, 2018; September-October, 2018) in randomized block design (RBD) consisting of 7 treatments in 3 replications. The treatments in this study included, T1: 100% N-P2O5-K2O+S+Zn with Urea-SSP-10:26:26 + Bentonite Sulphur (8 kg ha-1) + Zinc Sulphate (1 kg ha-1) as BF; T2: 75% BF; T3: 100% N-P2O5-K2O alone (Urea-SSP-10:26:26); T4: 75% N-P2O5-K2O alone (Urea-SSP-10:26:26); T5: 100% N-P2O5-K2O alone (Urea-DAP-MOP); T6: 100% N-P2O5-K2O alone (Urea-SSP-MOP) as farmers′ practice (FP); T7: Nutrients omission plot (Control). The recommended fertilizer dose (100%) for irrigated mulberry production in the Eastern region is N-P2O5-K2O=67-36-22 kg ha-1 crop-1. All the fertilizers were applied in two equal splits on 15th and 30th day after pruning.
Results: This study reveals the importance of balanced fertilization of mulberry with N, P, K, S and Zn for sustainable productivity, which is reflected by the maximum values for leaf yield attributes, chlorophyll content and leaf yield. Further, mulberry leaf quality (in terms of total soluble protein and total soluble sugar) significantly improved with balanced fertilization. Higher PFP and AUE were also recorded with fertilization with compound/complex fertilizers than with straight fertilizers; but the balanced fertilization exhibited remarkable enhancement.
Conclusion: The results prove that balanced fertilization of N-P2O5-K2O @ 67-36-22 kg ha-1 (Urea-SSP-10:26:26) with Bentonite sulphur (8 kg ha-1) and zinc sulphate (1 kg ha-1) were effective in improving mulberry productivity through enhanced nutrient use efficiency. This could be useful for realizing maximum productivity in mulberry as an efficient nutrient management strategy in mulberry cultivation.
Frequency of Hypoglycemia in Severe Acute Malnutrition
Authors: Zahirzay Mohammad Sedique , Chardiwal Haqiqullah , Azimee Mohammad Azim 
Published: October 2021

Malnutrition is a major health problem throughout the world and contributes to at least one third of all children deaths worldwide. Hypoglycemia is a basic metabolic complication in pediatric patients which can be easily prevented by proper care and management. Objective of this study was to determine the frequency of hypoglycemia in sever acute Malnurished children (SAM). The study was conducted in nutritional division of Nangarhar University Teaching Hospital pediatric department. For 8 months, all the patients were subjected for measurement of blood glucose level by glucose oxidase method .Hypoglycemia was labeled according to value mentioned in operational definition. The study included a total of 252 patients with SAM. 137 (54.4%) were Males and 115 (45.6%) females with no significant difference in the number of gender and with an average age of (Mean± SD) 16.20±11.74 (6 months to 60 months). Out of 252 patients 54.80% (138) were hypoglycemic, and 85.70% (216) suffering from Marasmus. 38.9% of children’s caregivers were illiterate and 86.5% poor and middle-level of socioeconomic status. 12.7%( 32) of the SAM children with hypoglycemia were dying, most of the patient from Nangarhar province.
Sever acute malnutrition (SAM) constitutes a significant health problem and important cause of mortality and morbidity in children, in marasmus patients the hypoglycemia is more common than kwashiorkor children; early diagnosis and treatment can prevent and decrease the morbidity and mortality of Sever acute malnutrition (SAM) in children significantly, education, socioecnomic status of caregivers are important in prevention of sever acute malnutrition (SAM) and their complications.
Carcinoma of Tail of Pancreas: A Case Report
Authors: Thakare Pratiksha , Ankar Ruchira , Sharma Ranjana , Gujar Samruddhi , Sheikh Shakib 
Published: October 2021

Background: A typical manifestation of pancreatic tail cancer is large intestinal obstruction with perforation. Clinically the cancer of pancreas is usually complicated to diagnose. Most cancer patients are not having symptoms throughout during the initial stages of the cancer, which often leads to a delay in diagnosis. Treatment choices include surgery, chemotherapy, and palliative care. It is more common in African-Americans, slightly more common in men.
Case Presentation: A female patient of 40 years from Wardha was admitted to Female surgery Ward, Unit-3, AVBRH on 18th December with a chief complaint of pain in epigastric region since 2weeks. Patient was apparently all right 2 months back then she was complaining of pain in the epigastric region which was insidious in onset, gradually progressive in nature, burning type of pain with radiating to left upper back. No history of fever, nausea vomiting, clay-coloured stools. After that patient was undergone on routine investigation in that total WBC count was increased i.e., 13000/cu mm and haemoglobin level were decreased i.e., 9.7gm%, liver biopsy revealed that metastasis of Adenocarcinoma probably of pancreatic origin, Computed tomography and ultrasound and it revealed that heterogenous iso-echoic mass in the tail of pancreas based on investigation she was diagnosed as a case of Carcinoma tail of pancreas and she was undergone on treatment of antibiotic before chemotherapy .after that chemotherapy treatment was done for management of pain.
Conclusion: Pancreatic adenocarcinoma presents differently from large intestinal cancer and should be explored in the differential diagnosis of large intestinal obstruction.
Assess the Relationship between Personality Traits (Neuroticism, Extraversion and Self-Efficacy) with Anxiety and Depression among Aging Population
Authors: Uke Trupti , Gawai Jaya , Kasturkar Pooja 
Published: October 2021

Background: Many people experience and deal with anxiety very efficiently at home, work place and every walk of their life. The beneficial outcomes of high level of anxiety are usually the effects and achievements you and others experience. On the outward, you should appear to be very effective in proper work and routinely lifestyle and this may be objectively perfect if you judge yourself on what you are accomplishing.
Aim: The aim is to assess the relationship between personality traits (neuroticism and extraversion and self-efficacy) with anxiety and depression among aging population.
Objectives: 1. To assess the relationship between personality traits of neuroticism with anxiety among aging population. 2. To assess the relationship between personality traits of neuroticism with depression among aging population. 3. To assess the relationship between personality traits of extraversion with anxiety among aging population. 4. To assess the relationship between personality traits of extraversion with depression among aging population.5. To assess the relationship between personality traits self-efficacy with anxiety among aging population.6. To assess the relationship between personality traits self-efficacy with depression among aging population.7.To compare the relationship between personality traits (neuroticism, extraversion and self-efficacy) with anxiety and depression among aging population.8.To correlate relationship between personality traits (neuroticism, extraversion and self-efficacy) with anxiety and depression among aging population.9.To associate score of personality traits (neuroticism extraversion and self-efficacy) with their selected demographic variables.
Methodology: The research design is cross-sectional study, and participants are, the aging populations. Sampling technique will be non-probability convenience sampling. Data will be obtained from the participants with the use of standardized scale personality five big inventory scale, self-efficacy scale, Hamilton-depression and Hamilton anxiety scale.
Results: There may be relationships between neuroticism, extraversion and self-efficacy with anxiety and depression among aging population and this relationship will be tested with demographic variables by regression analysis.
Conclusion: Findings will be drawn from the statistical analysis.
Early Identification and Prevention of Postnatal Complications among the Postnatal Mothers by Using the ‘Postnatal Care Bundle’
Authors: Taksande Vaishali , Shrivastava Deepti S. , Sebastian Sr. Tessy 
Published: October 2021

Background: Postnatal period initiates immediately after the birth of a baby. The terms puerperium period is commonly used to refer to the first 6 weeks after delivery of baby. A postnatal care bundle used during this period and it will help to significantly improve patient outcomes.
Objective: To develop, test and pilot of Postnatal Care Bundle (PNCB) and to assess conventional postnatal care among the postnatal mothers and to evaluate the effectivity of Postnatal Care Bundle (PNCB) for early identification and prevention of postpartum complications among the postnatal mothers and to assess the satisfaction level of staff nurses after implementation of Postnatal Care Bundle and conventional postnatal care for early identification and prevention of postnatal complications among the postnatal mothers.
Methodology: The interventional analytical and true experimental research design approach will be used and the sample use for the postnatal mothers including the full term normal delivery, caesarean section will be and the random sampling use and sample size is 185 in each group i.e. control and experimental group. One group will be received conventional postnatal care and other group will be on postnatal care bundle. The outcome includes that postnatal care bundle help to early identification and prevention of postnatal complications among the postnatal mothers.
Conclusion: PNCB will be effective in quality care of postnatal period.
Computed tomography–based radiomic analysis for prediction of treatment response to salvage chemoradiotherapy for locoregional lymph node recurrence after curative esophagectomy
Authors: Gu Liang , Liu Yangchen , Guo Xinwei , Tian Ye , Ye Hongxun , Zhou Shaobin , Gao Fei 
Published: October 2021

AbstractObjectiveTo investigate the capability of computed tomography (CT) radiomic features to predict the therapeutic response and local control of the locoregional recurrence lymph node (LN) after curative esophagectomy by chemoradiotherapy.MethodsThis retrospective study included 129 LN from 77 patients (training cohort: 102 LN from 59 patients; validation cohort: 27 LN from 18 patients) with postoperative esophageal squamous cell carcinoma (ESCC). The region of the tumor was contoured in pretreatment contrast‐enhanced CT images. The least absolute shrinkage and selection operator with logistic regression was used to identify radiomic predictors in the training cohort. Model performance was evaluated using the area under the receiver operating characteristic curves (AUC). The Kaplan–Meier method was used to determine the local recurrence time of cancer.ResultsThe radiomic model suggested seven features that could be used to predict treatment response. The AUCs in training and validated cohorts were 0.777 (95% CI: 0.667–0.878) and 0.765 (95% CI: 0.556–0.975), respectively. A significant difference in the radiomic scores (Rad‐scores) between response and nonresponse was observed in the two cohorts (p < 0.001, 0.034, respectively). Two features were identified for classifying whether there will be relapse in 2 years. AUC was 0.857 (95% CI: 0.780–0.935) in the training cohort. The local control time of the high Rad‐score group was higher than the low group in both cohorts (p < 0.001 and 0.025, respectively). As inferred from the Cox regression analysis, the low Rad‐score was a high‐risk factor for local recurrence within 2 years.ConclusionsThe radiomic approach can be used as a potential imaging biomarker to predict treatment response and local control of recurrence LN in ESCC patients.
High Current Density and Long Cycle Life Enabled by Sulfide Solid Electrolyte and Dendrite‐Free Liquid Lithium Anode
Authors: Peng Jian , Wu Dengxu , Song Fengmei , Wang Shuo , Niu Quanhai , Xu Jieru , Lu Pushun , Li Hong , Chen Liquan , Wu Fan 
Published: October 2021

AbstractLithium metal is the ideal anode candidate but suffers from great challenges including poor thermodynamic stability in liquid organic electrolytes and dendrite nucleation/growth during the continuous plating/stripping process. To solve the difficulties listed above, here, a battery configuration combining a liquid lithium solution anode, a sulfide solid electrolyte, and an interfacial protection layer is proposed to prevent interfacial reaction between the two components. This configuration combines the advantages of liquid‐lithium‐solution anode (dissolve lithium to essentially prevent lithium nucleation) and sulfide solid electrolyte (highest room‐temperature ionic conductivity among all solid electrolytes and ideal mechanical ductility for fully compact layer simply by cold pressing), so that a record‐high current density (17.78 mA cm−2) and long cycle life (nearly 3000 h) are realized. At the same time, the solubility of lithium metal in the liquid Li anode and electrochemical properties of liquid Li anode are systematically studied to find the most suitable liquid Li anode concentration with the highest room‐temperature conductivity (12.2 mS cm−1). This work provides a promising approach and battery configuration for achieving high‐specific‐capacity, high‐energy/power‐density and long‐cycle‐life secondary batteries.
Rational Design of All Resistive Multifunctional Sensors with Stimulus Discriminability
Authors: Lee Jeng‐Hun , Kim Eunyoung , Zhang Heng , Chen Haomin , Venkatesan Harun , Chan Kit‐Ying , Yang Jie , Shen Xi , Yang Jinglei , Jeon Seokwoo , Kim Jang‐Kyo 
Published: October 2021

AbstractA rational approach is proposed to design soft multifunctional sensors capable of detection and discrimination of different physical stimuli. Herein, a flexible multifunctional sensor concurrently detecting and distinguishing minute temperature and pressure stimuli in real time is developed using electrospun carbon nanofiber (CNF) films as the sole sensing material and electrical resistance as the only output signal. The stimuli sensitivity and discriminability are coordinated by tailoring the atomic‐ and device‐level structures of CNF films to deliver outstanding pressure and temperature sensitivities of −0.96 kPa−1 and −2.44% °C−1, respectively, enabling mutually exclusive sensing performance without signal cross‐interference. The CNF multifunctional sensor is considered the first of its kind to accomplish the stimulus discriminability using only the electrical resistance as the output signal, which is most convenient to monitor and process for device applications. As such, it has distinct advantages over other reported sensors in its simple, cost‐effective fabrication and readout system. It also possesses other invaluable traits, including good bending stability, fast response time, and long‐term durability. Importantly, the ability to simultaneously detect and decouple temperature and pressure stimuli is demonstrated through novel applications as a skin‐mountable device and a flexible game controller.
Custom Design of Protein Particles as Multifunctional Biomaterials
Authors: Shanbhag Bhuvana K. , Liu Chang , G.C. Pradeep , Younas Tayyaba , Hu Kevin K.Y. , Fulcher Alex J. , Struwe Weston B. , Steer David , Dumsday Geoff , Harper Ian S. , Kukura Philipp , Haritos Victoria S. , He Lizhong 
Published: October 2021

AbstractAssembled protein particles, as emerging biomaterials, have broad applications ranging from vaccines and drug delivery to biocatalysis and particle tracking, but to date these require trial‐and‐error rational design experimentation and/or intensive computational methods to generate. Here, the authors describe an easy‐to‐implement engineering strategy to generate customized protein particles as multifunctional biomaterials. They utilize protein–peptide modules to generate functional nanoparticles whose assembly and size is controlled by the addition of mild stimuli. The protein assembling method is versatile, as exemplified through particle formation with 7 distinct protein modules, using a variety of assembly conditions tailored by the chemistries of 3 peptide partners. They have generated customized protein particles using enzymes, binding and reporter proteins, and their functions and utilities are demonstrated using biocatalysis, sensing, and labelling applications, respectively. Furthermore, co‐assembly with two functional proteins within one particle has been successfully achieved and demonstrated. Physical insights into the kinetics and molecular mechanisms of particle formation are revealed by small angle X‐ray scattering and mass photometry, providing fundamental knowledge to guide design and manufacture these interesting biomaterials in future. Their protein assembling strategy is a reliable method for fabricating a protein particle to deliver new functionalities on‐demand.
Bioactive Synthetic Polymers
Authors: Jung Kenward , Corrigan Nathaniel , Wong Edgar H. H. , Boyer Cyrille 
Published: October 2021

AbstractSynthetic polymers are omnipresent in society as textiles and packaging materials, in construction and medicine, among many other important applications. Alternatively, natural polymers play a crucial role in sustaining life and allowing organisms to adapt to their environments by performing key biological functions such as molecular recognition and transmission of genetic information. In general, the synthetic and natural polymer worlds are completely separated due to the inability for synthetic polymers to perform specific biological functions; in some cases, synthetic polymers cause uncontrolled and unwanted biological responses. However, owing to the advancement of synthetic polymerization techniques in recent years, new synthetic polymers have emerged that provide specific biological functions such as targeted molecular recognition of peptides, or present antiviral, anticancer, and antimicrobial activities. In this review, the emergence of this generation of bioactive synthetic polymers and their bioapplications are summarized. Finally, the future opportunities in this area are discussed.
Direct Measurement of Oxygen Mass Transport at the Nanoscale
Authors: Baiutti Federico , Chiabrera Francesco , Diercks David , Cavallaro Andrea , Yedra Lluís , López‐Conesa Lluís , Estradé Sonia , Peiró Francesca , Morata Alex , Aguadero Ainara , Tarancón Albert 
Published: October 2021

AbstractTuning oxygen mass transport properties at the nanoscale offers a promising approach for developing high performing energy materials. A number of strategies for engineering interfaces with enhanced oxygen diffusivity and surface exchange have been proposed. However, the origin and the magnitude of such local effects remain largely undisclosed to date due to the lack of direct measurement tools with sufficient resolution. In this work, atom probe tomography with sub‐nanometer resolution is used to study oxygen mass transport on oxygen‐isotope exchanged thin films of lanthanum chromite. A direct 3D visualization of nanoscaled highly conducting oxygen incorporation pathways along grain boundaries, with reliable quantification of the oxygen kinetic parameters and correlative link to local chemistries, is presented. Combined with finite element simulations of the exact nanostructure, isotope exchange‐atom probe tomography allowed quantifying an enhancement in the grain boundary oxygen diffusivity and in the surface exchange coefficient of lanthanum chromite of about 4 and 3 orders of magnitude, respectively, compared to the bulk. This remarkable increase of the oxygen kinetics in an interface‐dominated material is unambiguously attributed to grain boundary conduction highways thanks to the use of a powerful technique that can be straightforwardly extended to the study of currently inaccessible multiple nanoscale mass transport phenomena.
T Cell‐Signaling‐Responsive Conjugate of Antibody with siRNA to Overcome Acquired Resistance to anti‐PD‐1 Immunotherapy
Authors: Wang Xingxing , Wang Yan , Li Ji , Tian Tian , Li Jinbo , Guo Zijian , Zhang Yan 
Published: October 2021

AbstractAcquired resistance (AR) resulted from stimulated expression of AR‐related genes such as CD38 in activated T cells jeopardizes anti‐programmed death‐1 (anti‐PD‐1) immunotherapy. It remains to be explored whether the suppression of AR genes in activated T cells during anti‐PD‐1 therapy is able to overcome AR and improve the efficacy of immunotherapy. Small‐interfering RNAs (siRNAs) acting via RNA interference mechanisms are able to shut down the expression of target genes. The authors report here a T‐cell targeting conjugate of antibody‐siRNA with response to reactive oxygen species (ROS) (TCARROS) for the suppression of AR gene as well as to block the PD‐1/PD‐L1 interaction. TCARROS is able to bind with PD‐1 on T cells, then release functional siRNA to suppress AR genes in activated T cells with abundant ROS to cleave the linker in the conjugate. TCARROS comprising the siRNA targeting CD‐38 attached to PD‐1 blocking antibody (αPD‐1) via the ROS responsive linker is tested on activated T cells as well as mice bearing B16 tumor. Synergistic effect is observed on mice treated with TCARROS in anti‐PD‐1 immunotherapy, which suggests the potentials of this novel ROS responsive αPD‐1‐siRNA conjugate in anti‐PD‐1 immunotherapy to overcome AR.
Aggregation‐enhanced direct S0–Tn transitions and room‐temperature phosphorescence in gold(I)‐complex single crystals
Authors: Ando Akihiro , Ozaki Kazuhisa , Shiina Urara , Nagao Eikichi , Hisano Kyohei , Kamada Kenji , Tsutsumi Osamu 
Published: October 2021

AbstractThe design of efficient aggregation‐induced emission materials requires an improved understanding of photophysical processes in aggregated materials. Herein, the photophysical behavior of an Au(I) complex (R6) that exhibits intense room‐temperature phosphorescence (RTP) in crystals is described. In addition, the photophysical processes related to RTP are discussed based on the structure of the molecular aggregates and the primary structure of the molecule. An extremely efficient S0–Tn direct transition is found to occur in the R6 crystal. Furthermore, intermolecular Au–Au interactions and the internal/external heavy‐atom effects of Au atoms are demonstrated to enhance the electronic transitions involving intersystem crossing, namely, direct S0–Tn excitation, radiative T1–S0 transition (phosphorescence), and S1–Tn intersystem crossing. Because of the dense molecular packing, both Au–Au interactions and heavy‐atom effects play important roles in the crystals. As a result, R6 shows more efficient RTP in crystals than in solution. These insights into the mechanism of highly efficient RTP in Au(I)‐complex crystals are expected to advance the development of new luminogens for a variety of sensing and imaging applications.