bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data-driven method for mobile game publishing revenue forecast
Authors: Su Yanhui , Backlund Per , Engström Henrik 
Published: December 2021

AbstractGames as a service is similar to software as a service, which provides players with game content on a continuous monetization model. Game revenue forecast is vital to game developers to make the right business decisions, such as determining the marketing budget, controlling the development cost, and setting up benchmarks for evaluating game publishing performance. How to make the revenue forecast and integrate it with the game publishing process is hard for small and medium-sized independent (indie) game developers. This includes all steps of the process, from forecasting to decision-making based on the results. This paper provides a data-driven method that uses the mobile game revenue forecast based on different time-series prediction models to drive the game publishing. We demonstrate how to use the data-driven method to guide an indie game studio to forecast revenue and then set the revenue forecast as the internal benchmark to drive game publishing. In practice, we involve a real game project from an indie game studio and provide guidance for one of their casual game projects. Then, based on the revenue forecast, we discuss how to set the revenue forecast as an internal benchmark and drive the actions for mobile game publishing. Finally, we make a conclusion on how our data-driven method can be used to drive mobile game publishing and also discuss future research work.
Current state of clinical development of TROP2-directed antibody–drug conjugates for triple-negative breast cancer
Authors: Marhold Maximilian 
Published: December 2021

SummaryAntibody–drug conjugates (ADCs) against numerous molecular targets are currently being developed for the treatment of breast cancer (BCa). While the first ADC directed against Her2, namely trastuzumab–emtansine, was approved several years ago, targeting of TROP‑2, an epithelial cell marker overexpressed in approximately 80% of triple-negative breast cancers (TNBC) has gained interest through positive clinical data reported for the compound sacituzumab–govitecan (SG) resulting from the phase 3 ASCENT trial. This short review summarizes the data that led to approval of SG and to take a closer look at the state of clinical development of other ADCs targeting TROP‑2 in TNBC.
Simultaneous Bifurcation of Limit Cycles and Critical Periods
Authors: Oliveira Regilene D. S. , Sánchez-Sánchez Iván , Torregrosa Joan 
Published: December 2021

AbstractThe present work introduces the problem of simultaneous bifurcation of limit cycles and critical periods for a system of polynomial differential equations in the plane. The simultaneity concept is defined, as well as the idea of bi-weakness in the return map and the period function. Together with the classical methods, we present an approach which uses the Lie bracket to address the simultaneity in some cases. This approach is used to find the bi-weakness of cubic and quartic Liénard systems, the general quadratic family, and the linear plus cubic homogeneous family. We finish with an illustrative example by solving the problem of simultaneous bifurcation of limit cycles and critical periods for the cubic Liénard family.
Health Status Stability of Patients in a Medical Rehabilitation Program: What Are the Roles of Time, Physical Fitness Level, and Self-efficacy?
Authors: Ju Qianqian , Gan Yiqun , Rinn Robin , Duan Yanping , Lippke Sonia 
Published: December 2021

AbstractBackgroundIndividuals’ physical and mental health, as well as their chances of returning to work after their ability to work is damaged, can be addressed by medical rehabilitation.AimThis study investigated the developmental trends of mental and physical health among patients in medical rehabilitation and the roles of self-efficacy and physical fitness in the development of mental and physical health.DesignA longitudinal design that included four time-point measurements across 15 months.SettingA medical rehabilitation center in Germany.PopulationParticipants included 201 patients who were recruited from a medical rehabilitation center.MethodsTo objectively measure physical fitness (lung functioning), oxygen reabsorption at anaerobic threshold (VO2AT) was used, along with several self-report scales.ResultsWe found a nonlinear change in mental health among medical rehabilitation patients. The results underscored the importance of medical rehabilitation for patients’ mental health over time. In addition, patients’ physical health was stable over time. The initial level of physical fitness (VO2AT) positively predicted their mental health and kept the trend more stable. Self-efficacy appeared to have a positive relationship with mental health after rehabilitation treatment.ConclusionsThis study revealed a nonlinear change in mental health among medical rehabilitation patients. Self-efficacy was positively related to mental health, and the initial level of physical fitness positively predicted the level of mental health after rehabilitation treatment.Clinical RehabilitationMore attention could be given to physical capacity and self-efficacy for improving and maintaining rehabilitants’ mental health.
A relict oasis of living deep-sea mussels Bathymodiolus and microbial-mediated seep carbonates at newly-discovered active cold seeps in the Gulf of Cádiz, NE Atlantic Ocean
Authors: Somoza Luis , Rueda José Luis , González Francisco J. , Rincón-Tomás Blanca , Medialdea Teresa , Sánchez-Guillamón Olga , Hoppert Michael , Vázquez Juan T. , Madureira Pedro , Santofimia Esther , López-Pamo Enrique , Palomino Desirée , Ortíz Jose Eugenio , Blanco Lorena , del Carmen Fernández-Puga Maria , Fernández-Salas L. M. , Reitner Joachim 
Published: December 2021

AbstractExtensive beds of the deep-sea mussel Bathymodiolus mauritanicus (currently also known as Gigantidas mauritanicus) linked to active cold seeps related to fissure-like activity on Al Gacel mud volcano, Gulf of Cádiz, were filmed and sampled for the first time during the oceanographic expedition SUBVENT-2 aboard R/V Sarmiento de Gamboa. Al Gacel mud volcano is one of up to 80 fluid venting submarine structures (mud volcanoes and mud volcano/diapir complexes) identified in the Gulf of Cádiz as result of explosive venting of hydrocarbon-enriched fluids sourced from deep seated reservoirs. This mud volcano is a cone-shaped edifice, 107 m high, 944 m in diameter constituted by mud breccias and, partially covered by pavements of seep carbonates. Extensive beds of this deep-sea mussel were detected at the northern flank at 810–815 m water depth associated with bacterial mats around intermittent buoyant vertical bubble methane plumes. High methane concentrations were measured in the water column above living mussel beds. Other chemosymbiotic species (Siboglinum sp., Solemya elarraichensis, Isorropodon sp., Thyasira vulcolutre and Lucinoma asapheus) were also found in different parts of Al Gacel mud volcano. Al Gacel mud volcano may currently represent one of the most active mud volcanoes in the Gulf of Cádiz, delivering significant amounts of thermogenic hydrocarbon fluids which contribute to foster the extensive chemosynthesis-based communities detected. This finding is of paramount importance for linking extremophile bivalve populations along the North Atlantic, including cold seeps of the Gulf of México, hydrothermal vents of the Mid-Atlantic Ridge and now, detailed documented at the Gulf of Cádiz.
Lessons Learned from the Occurrences of Major Devastating Mw ≥ 7.5 Earthquakes in the Asian Countries during the last 25 years
Authors: Mandal Prantik 
Published: December 2021

Abstract
The loss of human lives, properties and damages due to the occurrences of moderate to large size earthquakes have been a major concern for the economic development of many countries in the world. Earthquakes would continue to occur in a region and would remain among the most devastating natural hazards. Seismically active countries viz., China, India, Japan, USA, Mexico and a few other countries are classified as high earthquake hazard regions while continents/countries with low rate of earthquake occurrence include Africa, Australia, Canada etc. On many occasions in the past, high earthquake hazard countries have experienced major economic setbacks due to the occurrences of major earthquakes. In the present paper, the causative mechanisms of major devastating earthquakes of Mw≥7.5 in the Asian countries (including high hazard countries like China, Japan, India, Taiwan and Nepal) during the past 25 years and major damages rendered by these earthquakes is discussed.
Testing Earthquake Prediction Algorithms
Authors: Kossobokov Vladimir G. , Soloviev Aleksander A. 
Published: December 2021

Abstract
The problem of estimating efficiency and comparing different earthquake prediction algorithms remains pivotal for operational decision making and reducing losses from earthquakes. Healy et al. (1992) considered this problem in terms of strict mathematical analysis of the prediction outcomes in the design of Global Testing of the algorithm M8. For 30 years now, every six months, this earthquake prediction algorithm has been applied globally, determining in real time the areas in which the World’s largest earthquakes are most likely to occur in the current half-year. To date, the statistics of the results obtained in this Global Test indicates, with reliability higher than 99%, a fairly high efficiency of forecasts using the M8 algorithm, as well as in its combination with the MSc algorithm, which specifies the localization of the source zone of the expected earthquake. Thus, the null hypothesis of random occurrence in seismically active regions is rejected with seismological certainty, at least for the World’s largest earthquakes. The results of this experimental testing are an indirect confirmation of the predictability of strong earthquakes, as well as the existence of common dynamic characteristics and diverse behavior during phase transitions in a complex hierarchical nonlinear system of faults-and-blocks of the Earth’s lithosphere (Keilis-Borok, 1990).
Mapping Seismic Zones Based on the Geomorphic Indices and the Analytic Hierarchy Process (AHP): A Case Study in Cao Bang Province and Adjacent Areas (Vietnam)
Authors: Dinh Trong Cao , Dinh Trieu Cao , Anh Tuan Thai , Xuan Bach Mai , Manh Luc Nguyen , Thanh Duong Van , Van Dung Le , Thanh Hai Dang , Quang Toan Ngo 
Published: December 2021

Abstract
This paper presents the application of Digital Elevation Model (DEM) for mapping seismic zones in Cao Bang province and adjacent areas. The application of the Analytic Hierarchy Process (AHP) in this study consists of four analytical steps namely: (1) Determination of the geomorphic indices’ sensitivity with respect to the earthquake activity using the MLP (Multi-layer Perceptron) neural network; (2) Calculation of the weight coefficients of all indices according to principle Eigenvector (AHP method); (3) Estimation of the ranking sensitivity of each geomorphic indices to the earthquake activity using their value distribution and (4) Identification of the Seismic Susceptibility Index (SSI). The results show that there are 6 seismic zones in the study area, including Na Hang, where the largest earthquake occurred with M4.6 (November 1, 1943); Ha Giang M5.0 (August 18, 1975); Bao Lac M5.2 (June 13, 1968); Cao Bang-Tien Yen M5.0 (November 1, 1933); Quang Yen-Song Bang M4.6 (April 6, 1979) and Quay Son River M5.0 (November 25, 2019).
Skill in Means and Mindfulness
Authors: Anālayo Bhikkhu 
Published: December 2021

AbstractAn exploration of the relatively rare references to skill in means in early Buddhist texts points to a close relationship to the cultivation of mindfulness, under the overarching aim of establishing the mind in wholesome conditions and preventing the arising of what is unwholesome. At the same time, however, a particular narrative related to the Buddha’s half-brother Nanda and his struggle with sensual desire testifies to incipient tendencies for the evolution of a different conception of skill in means; in fact, to some extent this episode could even be considered an instance of proto-tantra.
Interdisciplinary perspective-taking within argumentation: students’ strategies across science and religious education
Authors: Fancourt Nigel , Guilfoyle Liam 
Published: December 2021

AbstractThe importance of developing students’ argumentation skills is well established across the curriculum: students should grasp how claims are made and supported in different disciplines. One challenge is to follow and thereby agree with or critique the arguments of others, which requires perspective-taking, in tracing these other reasons and reasoning. This challenge is increased when disciplines construct argumentation and perspective-taking differently. Here, we consider the role of perspective-taking in argumentation within and between science education and pluralistic religious education, where the former aims at the justification of scientific claims and the latter at both an empathetic understanding of different religions and worldviews, and personal reasoning. We interpretively analyze student data to identify salient features of students’ strategies to perspective-taking within argumentation. Data from 324 pupils across nine schools are explored in relation to students’ challenges in perspective-taking, strategies for perspective-taking within argumentation, and the use of perspective-taking to construct personal argumentation. The analysis shows some barriers to perspective-taking within argumentation, the range of students’ perspective-taking strategies within argumentation, and how personal argumentation could hermeneutically build upon perspective-taking strategies. The importance and implications of perspective-taking within argumentation across the curriculum are considered highlighting challenges in the etic/emic shift, both within the individual subject as well as across them, and some reflections on how this provides a fresh pedagogical perspective on the science/religions debate are made. To end, we conclude with the wider challenges for disciplines and perspective-taking across schooling and university.
COVID-19 Vaccine Acceptance is associated with Vaccine Hesitancy, Perceived Risk and Previous Vaccination Experiences
Authors: Dolu İlknur , Turhan Zeynep , Yalnız Dilcen Hacer 
Published: December 2021

Abstract

Objective:
This study examines the factors associated with the willingness to get the coronavirus vaccine among individuals aged 18 and above.

Methods:
This cross-sectional study was conducted in Turkey. The participants aged 18 and older were recruited between December, 2020 and January, 2021 through conventional social media sites. Snowball sampling was used. An anonymous questionnaire consisted of demographics, vaccination experiences, and perceived risk of coronavirus disease.

Results:
1202 women and 651 men were included in the data analysis. Findings showed that demographics, vaccination experience, and perceived risk of getting COVID-19 were explained. 37% of the variance in people’s willingness to get the COVID-19 vaccination was according to hierarchical logistic regression. Furthermore, increasing age, being male, acquiring positive information about COVID-19 vaccines, having a lower level of vaccine hesitancy, the high level of worry about COVID-19, and low level of perceptions of the possibility of becoming infected by the COVID-19 were the main predictors of COVID-19 vaccine willingness.

Conclusions:
Factors affecting adults’ willingness to be inoculated with COVID-19 vaccines were related to demographics, vaccination experiences, and perceived risk of getting COVID-19. We recommend that public health authorities and practitioners should consider these multiple factors regarding vaccine confidence to achieve herd immunity.
Innovative application of postbiotics, parabiotics and encapsulated Lactobacillus plantarum RM1 and Lactobacillus paracasei KC39 for detoxification of aflatoxin M1 in milk powder
Authors: Mogahed Fahim Karima , Noah Badr Ahmed , Gamal Shehata Mohamed , Ibrahim Hassanen Eman , Ibrahim Ahmed Lamiaa 
Published: December 2021

AbstractThis study aimed to evaluate aflatoxin M1 (AFM1) level in milk powder and infant milk formulae, in addition to applying innovative methods for AFM1 & AFB1 detoxification. Fifty random samples of milk powder and infant formulae (25 of each) were collected from the Egyptian markets for assessing AFM1 level using ELISA technique. Bioactive components comprising cell free supernatants (postbiotic), acid-dead cells (parabiotic) and the encapsulated-cells of Lactobacillus plantarum RM1 and Lactobacillus paracasei KC39 were evaluated for their antifungal activity against toxigenic mold strains and their impact on AFB1 and AFM1 reduction in reconstituted milk powder. AFM1 concentration in unpacked milk powder was higher than that of packed samples and infant formulae, although these differences were not significant (P > 0.05). About 96.0, 29.4 and 25.0% of the tested infant formulae, unpacked, and packed milk powder were unacceptable in terms of the AFM1 limit defined by Egyptian and European standards, while all samples were in accordance with the USA/FDA standard. All tested mycotoxigenic strains were sensitive to the different treatments of the probiotics with the highest sensitivity regarding Fusarium strain with L. paracasei KC39 compared to other genera. The degradation ratios of AFM1 using the bioactives of the L. paracasei KC39 were higher than that of L. plantarum RM1 bioactives. Additionally, KC39 parabiotic manifested the best AFB1 reduction (60.56%). In conclusion, the positive and highly significant relationship (P < 0.05) between these effective biocompounds mirrors their major detoxification role which gives a safe solution for AFs contamination issues in milk and milk products.
The moderation of the genetic risk for alcohol and drug use disorders in a Swedish national sample by the genetic aptitude for educational attainment
Authors: Kendler Kenneth S. , Ohlsson Henrik , Sundquist Jan , Sundquist Kristina 
Published: December 2021

AbstractBackgroundDoes the genetic aptitude for educational attainment (GAEA) moderate the genetic risk for alcohol use disorder (AUD) and drug use disorder (DUD)?MethodsIn the native Swedish population, born 1960–1980 and followed through 2017 (n = 1 862 435), the family genetic risk score (FGRS) for AUD and DUD and GAEA were calculated from, respectively, the educational attainment and risk for AUD and DUD, of 1st through 5th degree relatives from Swedish national registers. Analyses utilized Aalen's linear hazards models.ResultsRisk for AUD was robustly predicted by the main effects of FGRSAUD [b = 6.32 (95% CI 6.21–6.43), z = 64.9, p < 0.001) and GAEA [b = −2.90 (2.83–2.97), z = 44.1, p < 0.001] and their interaction [b = −1.93 (1.83–2.03), z = 32.9, p < 0.001]. Results were similar for the prediction of DUD by the main effects of FGRSDUD [b = 4.65 (CI 4.56–4.74), z = 59.4, p < 0.001] and GAEA [−2.08 (2.03–2.13), z = 46.4, p < 0.001] and their interaction [b = −1.58 (1.50–1.66)), z = 30.2, p < 0.001]. The magnitude of the interactions between GAEA and FGRSAUD and FGRSDUD in the prediction of, respectively, AUD and DUD was attenuated only slightly by the addition of educational attainment to the model.Conclusions and relevanceThe genetic propensity to high educational attainment robustly moderates the genetic risk for both AUD and DUD such that the impact of the genetic liability to AUD and DUD on the risk of illness is substantially attenuated in those with high v. low GAEA. This effect is not appreciably mediated by the actual level of educational attainment. These naturalistic findings could form the basis of prevention efforts in high-risk youth.
Open Astronomy and Big Data Science
Authors: Koribalski Bärbel S. 
Published: December 2021

AbstractOpen Astronomy is an important and valuable goal, including the availability of refereed science papers and user-friendly public astronomy data archives. The latter allow and encourage interested researchers from around the world to visualise, analyse and possibly download data from many different science and frequency domains. With the enormous growth of data volumes and complexity, open archives are essential to explore ideas and make discoveries. Open source software is equally important for many reasons, including reproducibility and collaboration. I will present examples of open archive and software tools, including the CSIRO ASKAP Science Data Archive (CASDA), the Local Volume HI Survey (LVHIS), the 3D Source Finding Application (SoFiA) and the Busy Function (BF). Astronomy is international and includes or links to an incredibly wide range of sciences, computing, engineering, and education. Its open nature can serve as an example for world-wide interdisciplinary collaborations.
Role of Contamination in Optimal Droplet Production by Collective Bubble Bursting
Authors: Néel B. , Erinin M. A. , Deike L. 
Published: December 2021

AbstractGas bubbles bursting at the sea surface produce drops, which contribute to marine aerosols. The contamination or enrichment of water by surface‐active agents, of biological or anthropogenic origin, has long been recognized as affecting the bubble bursting processes and the spray composition. However, despite an improved understanding of the physics of a single bursting event, a quantitative understanding of the role of the physico‐chemical conditions on assemblies of bursting bubbles remains elusive. We present experiments on the drop production by millimetric, collective bursting bubbles, under varying surfactant concentration and bubble density. We demonstrate that the production of supermicron droplets (with radius larger than 35 μm) is non‐monotonic as the surfactant concentration increases. The bursting efficiency is optimal for short‐lived, sparsely distributed and non‐coalescing bubbles. We identify the combined role of contamination on the surface bubble arrangement and the modification of the jet drop production process in the bursting efficiency.
Energetic Electron Precipitation Driven by the Combined Effect of ULF, EMIC, and Whistler Waves
Authors: Bashir M. Fraz , Artemyev Anton , Zhang Xiao‐Jia , Angelopoulos Vassilis 
Published: December 2021

AbstractEnergetic electron losses in the Earth's inner magnetosphere are dominated by outward radial diffusion and scattering into the atmosphere by various electromagnetic waves. The two most important wave modes responsible for electron scattering are electromagnetic ion cyclotron (EMIC) waves and whistler‐mode waves (whistler waves) that, acting together, can provide rapid electron losses over a wide energy range from few keV to few MeV. Wave‐particle resonant interaction resulting in electron scattering is well described by quasi‐linear diffusion theory using the cold plasma dispersion, whereas the effects of nonlinear resonances and hot plasma dispersion are less well understood. This study aims to examine these effects and estimate their significance for a particular event during which both wave modes are quasi‐periodically modulated by ultra‐low‐frequency (ULF) compressional waves. Such modulation of EMIC and whistler wave amplitudes provides a unique opportunity to compare nonlinear resonant scattering (important for the most intense waves) with quasi‐linear diffusion (dominant for low‐intensity waves). The same modulation of plasma properties allows better characterization of hot plasma effects on the EMIC wave dispersion. Although hot plasma effects significantly increase the minimum resonant energy, Emin, for the most intense EMIC waves, such effects become negligible for the higher frequency part of the hydrogen‐band EMIC wave spectrum. Nonlinear phase trapping of 300–500 keV electrons through resonances with whistler waves may accelerate and make them resonant with EMIC waves that, in turn, quickly scatter those electrons into the loss‐cone. Our results highlight the importance of nonlinear effects for simulations of energetic electron fluxes in the inner magnetosphere.