bluuebunny/crossref_metadata_2025_split huggingface dataset:
KNOWLEDGE AND PREVALENCE OF RISK FACTORS FOR DEEP VEIN THROMBOSIS AMONG ADULT SAUDI POPULATION
Authors: Aljaroof Abdulla Hassan 
Published: January 2021

While the reported annual incidence of venous thrombo-embolism varies widely, ranging from 43.7 to 145 per 100 000, the true incidence in the Kingdom of Saudi Arabia (KSA) remains unknown. Deep Vein Thrombosis (DVT) is a term that refers to blood clots inside a deep vein in the body, most commonly in lower extremities (usually calf or thigh); in rare cases, it can be in upper extremities. The main aim of this study was to assess the public knowledge and extent of DVT and to assess the influence of socio-demographic factors. The objectives were:

To test the association between gender and the prevalence of DVT.
To test the association between body mass index (BMI) and the prevalence of DVT.
To test whether recent or current pregnancy and DVT are significantly associated.
To test the significance of a family history of DVT and the prevalence of DVT among members of the same family.
To fit binary logistic models that flag the important factors for DVT

Methods
The study was cross-sectional and it involved the adult population in Saudi Arabia. The total enumeration method was used to include male and female that agreed to answer the questionnaire in this study. The questionnaire included demographic information and knowledge and attitudes towards the symptoms, and risk factors measures.
Results
The ages of 317 of the 484 respondents who agreed to fill out the questionnaire were between 19 and 30 years. Males were 35.8% and females 64.2%, while 21.8% of the respondents reported having an incidence of DVT. DVT was statistically significantly associated with gender and pregnancy condition p<.05 in both cases while the highest risk factor was gender where females were 2.205 more times likely to have DVT than males [95%CI;1.85,2.63, p < .000].
Conclusions
There is a general increase in knowledge for DVT and also a general increase in incidences of DVT in Saudi Arabia compared to previous literature. BMI, gender, and pregnancy condition are the main risk factors of DVT.
Keywords: Deep vein thrombosis, risk factors, Surgery, Saudi Arabia
Konstruksi Reputasi dan Responsivitas Instansi Pemerintah Melalui Media Sosial pada Situasi Pandemi Covid-19 di Indonesia (Analisis Wacana Pada Laman Facebook Direktorat Jenderal Perbendaharaan Kementerian Keuangan RI)
Authors: Nur Muhammad 
Published: January 2021

Government agencies are required to continue to work and provide optimal and responsive public services to various issues and conditions. Preaching on social media can be a medium for government agencies to construct certain discourses, such as a responsive attitude to the current emergency situations. DGT as a government agency under the Ministry of Finance of the Republic of Indonesia responsible for managing the State Budget has a business continuity plan (BCP) that is responsive to various situations that occur. This article aims to find and explain the news construction process in the Facebook social media account of DJPb which shows the responsiveness of DJPb in the Covid-19 pandemic situation in Indonesia. This study uses Teun A. Van Dijk's discourse analysis (DA) method to find textual components (news schemes) of the news and texts on DJPb’s Facebook page. The results showed that there was a reputation and responsiveness construction process in the form of discourse produced in the news on DJPb's Facebook social media account during the Covid-19 pandemic situation in Indonesia. DJPb’s responsiveness is important and very necessary to ensure that public services related to disbursement of APBN such as employee salaries, BOS funds, UMi credit, etc. including APBN funds for handling in emergency situations such as the Covid-19 pandemic can continue to run well to support the implementation of government’s programs.
Faktor-Faktor yang Mempengaruhi Rasio Beban Pajak Perusahaan: Studi Empiris Sektor Manufaktur di Indonesia
Authors: Kurniawan Tria Sandi 
Published: January 2021

This paper examines corporate tax ratio of manufacturing sector in Indonesia. In this study, we use firm level data from Industry Survey of Central Bureau of Statistics. The result shows that in small and medium company percentage of foreign ownership is a significant determinant of tax ratio, whereas in big companies capital is a significant determinant of tax ratio. This study also find that there is negative relationship between profitability and tax ratio. This indicates that there is tax avoidance risk in manufacturing sector in Indonesia. Further examination shows that industry of coal and oil refining product and also repair and installation of machinery and equipment has the biggest risk of tax avoidance. Therefore we recommend subsectoral tax audit for to prove the findings of this study.

Penelitian ini menganalisis tax ratio perusahaan pada sektor manufaktur di Indonesia. Dalam penelitian ini digunakan data mikro perusaahaan manufaktur yang bersumber dari Survei Industri Badan Pusat Statistik. Hasil analisis menunjukkan bahwa terdapat hubungan positif antara kepemilikan asing dan tax ratio pada perusahaan menengah dan kecil, hal ini berbeda dengan pada perusahaan besar dimana kapital merupakan faktor yang mempengaruhi tax ratio. Hasil analisis juga menunjukkan bahwa terdapat hubungan negatif antara profitabilitas dan tax ratio. Hal ini mengindikasikan bahwa terdapat resiko penghindaran pajak pada sektor manufaktur di Indonesia. Penelitian lebih lanjut mengungkapkan bahwa industri produk dari batu bara dan pengilangan minyak bumi serta usaha reparasi dan pemasangan mesin dan peralatan merupakan industri dengan resiko penghindaran pajak yang terbesar. Oleh karena itulah kami menyarankan agar dilakukan pemeriksaan pajak subsektoral untuk membuktikan temuan pada penelitian ini.
La productividad y tipos de turismo en la provincia de Los Ríos
Authors: Rivera García Christian , Parra Cerezo Glenda 
Published: January 2021

Esta investigación tiene como objetivo aprovechar la productividad agrícola para ampliar las posibilidades de emprendimientos turísticos en la provincia, en base a la tipología de turismo bifurcada en todo el territorio fluminense, el emprendimientos turísticos confluyen en iniciar una inversión de negocio con capital directo o financiado, que involucre al talento humano con sus múltiples recursos. El análisis de mercado es fundamental para ensamblar la iniciativa dentro de políticas estatales a bajo interés con facilidades de pago, buscar aliados estratégicos es clave para emprender iniciativas turísticas comunitarias a gran escala, favoreciendo la asociatividad y la convivencia cultural sobre los recursos naturales y culturales en crecimiento micro empresarial. Este sector se vuelve vulnerable cuando se trabaja independientemente las ideas de negocios, a excepción del poder adquisitivo que posea la persona o grupo familiar que conforman el proyecto, el asesoramiento técnico desde la empresa pública y privada incentiva la participación de organizaciones campesinas bien organizadas, con metas y objetivos establecidos con anterioridad, el emprendimiento informal se transforma en trabajo desleal hacia emprendimiento debidamente reconocidos en las instituciones tributarias, encontrando limitaciones de crecimiento económico, pero exigiendo nuevas iniciativas e innovaciones en promociones de productos comerciales de primera necesidad hacia el mercado identificado como meta.
Los valores morales en la formación del profesional de Turismo
Authors: Rivera García Christian , Parra Cerezo Glenda 
Published: January 2021

La presente investigación pretende analizar la aplicación de los valores éticos y morales en el funcionamiento de los profesionales de la carrera de turismo, ampliar la relación profesional entre docentes y estudiantes en pleno cumplimiento de normas institucionales que rescaten el valor de “te doy mi palabra” en otrora marca de honradez y confiabilidad suprema, la presencia de la moralidad es innata, aunque obscurecida por la ambición de poder y dinero fácil. Lo único que queda es el autocompromiso de cumplir lo prometido sin embargar la verdad ni la credibilidad de los docentes universitarios y de los futuros profesionales en las labores con la sociedad civil. Las encuestas reflejan el limbo de los métodos investigativos en raciocinio bidireccional de falso cumplimiento, el código binario se argumenta en valores y en antivalores coyunturales perniciosos que perfilan a líderes y lideresas de papel con pies de barro, esta inflexión académica implícita en los contenidos curriculares se rescata con vehemencia argumentativa de valorar los antivalores
La Gestión de la Innovación en las Agencias de Viajes Cubanas
Authors: Olivera Elosegui Rebeca 
Published: January 2021

La innovación se ha convertido en uno de los instrumentos fundamentales dentro de las empresas que quieren seguir siendo competitivas en un entorno cada vez más complejo y cambiante. No obstante, muchas entidades del sector turístico cubano, específicamente las agencias de viajes, presentan una insuficiente Gestión de la Innovación y se desconoce cuál es su situación actual. Por lo que se plantea como objetivo de la presente investigación: Valorar la gestión de la innovación en las agencias de viaje generalistas, pertenecientes a (OSDE) Viajes Cuba. Para ello se determinó aplicar en tres agencias de viajes, uno de estos modelos de diagnóstico y mejora de la gestión de la innovación: Guía para la Autoevaluación de la Gestión de la Innovación) Empresarial elaborada por Centro Andaluz para la Excelencia en la Gestión, (2009), El Modelo de las 7 Dimensiones (7 D´s) de Arzola & Mejías, (2007), y la fusión del modelo del Centro de Innovación y Desarrollo Empresarial de la Generalitat de Catalunya (CIDEM) desarrollado en el año 2002 y el procedimiento para la evaluación de la Gestión de la Innovación propuesto por la misma institución en el 2009. Las etapas correspondientes al diagnóstico dentro de estas metodologías incluyeron la aplicación de cuestionarios, entrevistas a directivos, entrevista a profundidad a especialistas de I+D+i y análisis documental. El diagnóstico y la aplicación de la Matriz de Vester, el árbol de problemas y el árbol de objetivos, posibilitaron la identificación de las brechas existentes entre el estado ideal y actual, permitiendo estructurar el marco lógico para la mejora, así como establecer un conjunto de indicadores para la planificación y el control en estas instituciones turísticas.
Practical Clinical and Diagnostic Pathway for the Investigation of the Infertile Couple
Authors: Garolla Andrea , Pizzol Damiano , Carosso Andrea Roberto , Borini Andrea , Ubaldi Filippo Maria , Calogero Aldo Eugenio , Ferlin Alberto , Lanzone Antonio , Tomei Francesco , Engl Bruno , Rienzi Laura , De Santis Lucia , Coticchio Giovanni , Smith Lee , Cannarella Rossella , Anastasi Attilio , Menegazzo Massimo , Stuppia Liborio , Corsini Christian , Foresta Carlo 
Published: January 2021

CapsuleThis expert opinion summarizes current knowledge on risk factors for infertility and identifies a practical clinical and diagnostic approach for the male and female partners of an infertile couple aimed to improve the investigation and management of fertility problems.BackgroundInfertility represents an important and growing health problem affecting up to 16% of couples worldwide. In most cases, male, female, or combined factor can be identified, and different causes or risk factors have been related to this condition. However, there are no standardized guidelines on the clinical-diagnostic approach of infertile couples and the recommendations concerning infertility are sometimes lacking, incomplete, or problematic to apply.ObjectiveThe aim of this work is to provide an appropriate clinical and diagnostic pathway for infertile couples designed by a multidisciplinary-team of experts. The rationale is based on the history and physical examination and then oriented on the basis of initial investigations. This approach could be applied in order to reduce variation in practice and to improve the investigation and management of fertility problems.MethodsProminent Italian experts of the main specialties committed in the ART procedures, including gynecologists, andrologists, embryologists, biologists, geneticists, oncologists, and microbiologists, called “InfertilItaly group”, used available evidence to develop this expert position.OutcomesStarting from the individuation of the principal risk factors that may influence the fertility of females and males and both genders, the work group identified most appropriate procedures using a gradual approach to both partners aimed to obtain a precise diagnosis and the most effective therapeutic option, reducing invasive and occasionally redundant procedures.ConclusionsThis expert position provides current knowledge on risk factors and suggests a diagnostic workflow of infertile couples. By using this step-by-step approach, health care workers involved in ART, may individuate a practical clinical management of infertile couples shared by experts.
A Novel mRNA-miRNA Regulatory Sub-Network Associated With Prognosis of Metastatic Clear Cell Renal Cell Carcinoma
Authors: Yang Tianyu , Miao Xiaofen , Bai Zhanxiang , Tu Jian , Shen Shanshan , Niu Hui , Xia Wei , Wang Juan , Zhang Yongsheng 
Published: January 2021

BackgroundClear cell renal cell carcinoma (ccRCC) is a urinary disease with high incidence. The high incidence of metastasis is the leading cause of death in patients with ccRCC. This study was aimed to identify the gene signatures during the metastasis of ccRCC.MethodsTwo datasets, including one gene expression profile dataset and one microRNA (miRNA) expression profile dataset, were downloaded from Gene Expression Omnibus (GEO) database. The integrated bioinformatics analysis was performed using the (limma) R package, miRWalk, DAVID, STRING, Kaplan-Meier plotter databases. Quantitative real-time polymerase chain reaction (qPCR) was conducted to validate the expression of differentially expressed genes (DEGs) and DE-miRNAs.ResultsIn total, 84 DEGs (68 up-regulated and 16 down-regulated) and 41 DE-miRNAs (24 up-regulated and 17 down-regulated) were screened from GSE22541 and GSE37989 datasets, respectively. Furthermore, 11 hub genes and 3 key miRNAs were identified from the PPI network, including FBLN1, THBS2, SCGB1A1, NKX2-1, COL11A1, DCN, LUM, COL1A1, COL6A3, SFTPC, SFTPB, miR-328, miR-502, and miR-504. The qPCR data showed that most of the selected genes and miRNAs were consistent with that in our integrated analysis. A novel mRNA-miRNA network, SFTPB-miR-328-miR-502-miR-504-NKX2-1 was found in metastatic ccRCC after the combination of data from expression, survival analysis, and experiment validation.ConclusionIn conclusion, key candidate genes and miRNAs were identified and a novel mRNA-miRNA network was constructed in ccRCC metastasis using integrated bioinformatics analysis and qPCR validation, which might be utilized as diagnostic biomarkers and molecular targets of metastatic ccRCC.
Phenotypical Changes of Hematopoietic Stem and Progenitor Cells in Sepsis Patients: Correlation With Immune Status?
Authors: Wang Ping , Wang Jun , Li Yi-hao , Wang Lan , Shang Hong-cai , Wang Jian-xun 
Published: January 2021

Background: Sepsis is life-threatening organ dysfunction associated with high risk of death. The immune response of sepsis is complex and varies over time. The immune cells are derived from hematopoietic stem and progenitor cells (HSPCs) which can respond to many infections. Our previous study found that sepsis causes HSPC dysregulation in mouse. But few studies have previously investigated the kinetics of HSPC and its contribution to immune system in sepsis patients.Purpose: We aimed to identify the kinetics of HSPCs and their contribution to immune system in sepsis patients.Methods: We enrolled eight sepsis patients and five healthy control subjects. Peripheral blood (PB) samples from each patient were collected three times: on the first, fourth, and seventh days, once from each healthy control subject. Peripheral blood mononuclear cells (PBMCs) were isolated by density centrifugation and stained with cocktails of antibodies. Populations of HSPCs and their subpopulation were analyzed by flow cytometry. Immune cells were characterized by flow cytometry and blood cell analysis. Correlations between HSPCs and immune cells were analyzed using the Pearson correlation test.Results: We found that the frequency of HSPCs (CD34+ cells and CD34+CD38+ cells) in sepsis patients on day 4 was significantly higher than that in the healthy controls. The most pronounced change in subpopulation analysis is the frequency of common myeloid progenitors (CMPs; CD34+CD38+CD135+CD45RA−). But no difference in the immunophenotypically defined hematopoietic stem cells (HSCs; CD34+CD38−CD90+CD45RA−) in sepsis patients was observed due to rare HSC numbers in PB. The number of PBMCs and lymphocytes are decreased, whereas the white blood cell (WBC) and neutrophil counts were increased in sepsis patients. Importantly, we found a negative correlation between CD34+ on day 1 and WBC and lymphocytes on day 4 from correlation analysis in sepsis patients.Conclusion: The present study demonstrated that the HSPC and its subpopulation in sepsis patients expanded. Importantly, the changes in HSPCs at early time points in sepsis patients have negative correlations with later immune cells. Our results may provide a novel diagnostic indicator and a new therapeutic approach.
Kadar Prostaglandin dan Endorfin pada Remaja dengan Dismenore Primer yang diberi Hidroterapi Hangat dan Dingin
Authors: Asrina Andi , Aryadi Arsyad , Andi Nilawati 
Published: January 2021

This study aims to determine the comparison of prostaglandin and endorphin levels in adolescents with primary dysmenorrhea with and without warm (37-40oC) and cold (18-20oC) hydrotherapy. This quasi-experimental study with a post-test only controls group design was carried out in Islamic Boarding Schools with a sample of 36 young girls divided into 3 groups: 12 teens given warm hydrotherapy, 12 teens given cold hydrotherapy and 12 teens not given intervention (control). Blood plasma is taken after an intervention is given on the first day of menstruation. Examination of prostaglandin and endorphins levels using the enzyme-linked immunosorbent assay (ELISA) kit method. After cold hydrotherapy, the mean levels of prostaglandins in the cold hydrotherapy group were twice higher (569 pg/ml) compared to controls (394 pg/ml). The mean prostaglandin level in the warm hydrotherapy group also showed an increase prostaglandin (437 pg/ml) compared to the control (394 pg/ml). In addition to increasing levels of prostaglandins, increased levels of endorphins also occurred in the group given warm hydrotherapy (154 pg/ml) and the group was given cold hydrotherapy (187 pg/ml) compared to the control (119 pg/ml) p = 0.001. The conclusion in this study is that warm and cold hydrotherapy can increase levels of prostaglandins and endorphins in adolescents with primary dysmenorrhea. However, cold hydrotherapy increases endorphin levels higher than warm hydrotherapy.
Key words: Prostaglandin, Endorphin, Hydrotherapy, Primary Dismenorrhea.
Intraocular silicone oil removal: timing, outcome, and silicone oil complications encountered
Authors: Ismail Nurul Shima , Phang Ling Kiet , Min Teh Wee , Abdul Halim Wan Haslina Wan , Ali Haslina Mohd 
Published: January 2021

Introduction: Silicone oil is the preferred tamponade agent used in pars-plana vitrectomy for retinal detachment when a long duration of endotamponade is intended. Due to its possible long-term complications, removal of silicone oil (ROO) is recommended.
Purpose: This study is done to evaluate the mean duration and complications of silicone oil tamponade, and the anatomical and visual outcomes after silicone oil removal.
Study design: Retrospective study.
Materials and methods: Retrospective review was done on 55 eyes of 55 patients, in which ROO was carried out at Hospital Sultanah Bahiyah in 2016 with a minimum six months follow-up postoperatively.
Results: The duration of silicone oil tamponade in these eyes ranged from 1.0 to 55.5 months, with mean duration of 10.8 months (SD 7.74). Common complications of silicone oil tamponade observed were cataract in 30 eyes (54.5%), followed by secondary high intraocular pressure in 6 eyes (10.9%), and band keratopathy in 3 eyes (5.5%). Six eyes (10.9%) developed retinal re-detachment after oil removal. The majority in the anatomically attached group post ROO (40 eyes, 81.6%) showed improvement of vision after ROO, with mean best corrected vision of LogMAR 1.38 (6/150) with silicone oil in situ to LogMAR 0.88 (6/48) at the latest follow-up.
Conclusions: Although the recommended duration of silicone oil tamponade ranges from three to six months, the optimal timing for silicone oil removal still remains unknown. ROO is recommended due to oil-related complications, but the anatomical outcome should be evaluated as well. However, in our setting, with limited resources and time, and increasing number of patients indicated for silicone oil, it is impossible to comply with the recommended time for ROO and the timing is usually set on an individual basis.
Efficacy of selective laser trabeculoplasty in primary open-angle glaucoma: HKL experience, one-year results
Authors: Chun Lim Chuan , Noor Jelinar Mohamed , Ramli Norlina Mohd , Wang Ch'ng Tun , Hui Gan Eng 
Published: January 2021

Introduction: Selective laser trabeculoplasty (SLT) has been demonstrated to lower intraocular pressure (IOP) and reduce the number of topical medications used in patients with primary open-angle glaucoma (POAG).
Purpose: The purpose of our study was to investigate the sustainability and efficacy of SLT in treating POAG at one year following laser. To our knowledge, this is one of the first studies to be published based on local data in Malaysia.
Study design: This was a retrospective study conducted in a specialist eye clinic, Hospital Kuala Lumpur, from July 2017 until January 2019. Data was collected from the medical notes of the patients.
Materials and methods: The study recruited cases of POAG patients who were using topical antiglaucoma medications. Inclusion criteria were patients with unilateral or bilateral POAG aged 50 years and above. Exclusion criteria were secondary open-angle glaucoma and all forms of angle-closure glaucoma. Patients who had undergone trabeculectomy or glaucoma drainage devices were excluded in our study. A single session of 360° SLT using a Q-switched Nd:YAG laser with an initial energy of 0.8 mJ was performed. IOP and number of antiglaucoma medications were recorded at prestudy, 1 week, 1 month, 3 months, 6 months, and 12 months.
Results: In 17 eyes, mean prestudy IOP was 19.3 ± 3.3 mmHg while on 2.18 ± 0.7 eye drops. At 12 months after SLT, mean IOP was 13.3 ± 3.5 mmHg while on 1.88 ± 0.9 IOP-lowering eye drops. This represented a 31% reduction of IOP compared to prestudy levels. However, the reduction of number of medications was not statistically significant.
Conclusion: A single session of 360° SLT treatment for POAG patients is able to lower IOP by 31% at one year following laser. SLT is a safe and effective procedure for reducing IOP. It may be used as adjuvant therapy, especially in noncompliant patients; patients who have difficulty applying topical eye drops or who are intolerant to topical medication.