bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Cash Management Practices toward Financial Performance of Small and Medium Enterprises in Indonesia
Authors: Amini Nuzulia , Setiono Bambang , Pangaribuan Christian Haposan , Princes Elfindah 
Published: July 2021

Objective – The importance of SMEs in Indonesia has been becoming the center of attention for the government to help the national economy grow. However, there are still many problems that hinder the potential of SMEs to develop. One of the problems is financial Management in terms of cash management, which can help SMEs have better Management over cash and better performance. Therefore, this study aims to analyze the current two elements of cash management practice, forecasting (FOR) and cash mobilization (CML) done by SMEs in Indonesia and its impact on Return on Assets (ROA) and Gross Profit Margin (GPM) as the financial performance measurements.
Methodology – The research uses a quantitative approach from 90 SMEs in Java and Bali islands from April until July 2018. The data were analyzed descriptively using a 4-point scale questionnaire. A regression analysis was added to find out significant relationships between the variables.
Findings – The research found that SMEs owners/managers often do forecasting and rarely do cash mobilization practices. The regression analysis shows a significant relationship between cash management practices and ROA but a non-significant relationship between cash management practices and Gross Profit Margin (GPM).
Novelty – This research provides an insight of how cash management practices influence the financial performance in the context of SMEs.
Enterprise Resource Planning (ERP) Evaluation and Implementation: A Case Study
Authors: Yosevine Prisca , Oetama Raymond Sunardi , Setiawan Johan , Princes Elfindah 
Published: July 2021

Objective – To understand the success rate of ERP in the company by using the Ifinedo method and provide proposals that can improve ERP implementation in the company based on the unfulfilled Ifinedo method.
Methodology – This research uses Quantitative method research distributed to 50 end users at Indoporcelain using surveys and interviews.
Findings – The research found one point that is less valued in the company, namely vision and mission factors in organizational variables compared to other factors. Therefore, proposals in this sector are indispensable in order to increase the success of ERP implementation in the company. Furthermore, lack of IT support due to the management’s ignorance has made the ERP implementation did not reach the optimum performance expected.
Novelty – By measuring the success rate of ERP in the company, the company can know how the success rate of ERP implementation in its company. The company can make corrections and quality improvements to existing ERP systems based on proposals with unmet Ifinedo method.
Zes jaar later: met z’n allen verstrikt geraakt in het stelsel?!
Authors: Lam E. , Schepens I.J.M. 
Published: July 2021

Zes jaar later: met z’n allen verstrikt geraakt in het stelsel?!
Dit artikel borduurt voort op de in 2014 en 2017 verschenen overzichtsartikelen over de twee belangrijke wetswijzigingen op het gebied van de jeugdbescherming en de jeugdzorg: de herziening van de kinderbeschermingsmaatregelen en de jeugdwet . De bedoeling van dit artikel is om een overall beeld te schetsen: een beeld dat duidelijk maakt hoe complex de ondersteuning aan kinderen en gezinnen is georganiseerd waarbij het recht op bescherming van de kinderen door de overheid ernstig onder druk staat. In het eerste deel van dit artikel wordt stilgestaan bij actuele ontwikkelingen stelselbreed. Vervolgens wordt stilgestaan bij de praktijk van de kinderbeschermingsmaatregelen. Achtereenvolgens komen aan de orde de evaluatie herziening kinderbeschermingsmaatregelen, het aantal kinderbeschermingsmaatregelen, de krapte bij de Gecertificeerde Instellingen (hierna: GI): wachtlijsten en de rechtspraak, corona en de invloed op jeugdbescherming, Perspectiefbesluit, Machtiging uithuisplaatsing en reikwijdte, Vaststelling omgangsregeling en Ineffectieve OTS. In het laatste deel van het artikel staan de bevindingen betreffende de Jeugdwet centraal. Daarbij wordt aandacht besteed aan onder meer de zogenaamde ‘drangtrajecten’, het woonplaatsbeginsel, de informatieplicht jegens de gezinsvoogd en het klacht- en tuchtrecht.
Chordoma
Authors: Ulici Veronica , Hart Jesse 
Published: July 2021

Context.—
Chordomas are uncommon malignant neoplasms with notochordal differentiation encountered by neuropathologists, bone/soft tissue pathologists, and general surgical pathologists. These lesions most commonly arise in the axial skeleton. Optimal therapy typically involves complete surgical resection, which is often technically difficult owing to the anatomic location, leading to a high rate of recurrence. Lesions have been generally resistant to radiation and chemotherapy; however, experimental studies involving targeted therapy and immunotherapy are currently underway.

Objective.—
To summarize the clinical and pathologic findings of the various types of chordoma (conventional chordoma, dedifferentiated chordoma, and poorly differentiated chordoma), the differential diagnosis, and recent advances in molecular pathogenesis and therapeutic modalities that are reliant on accurate diagnosis.

Data Sources.—
Literature review based on PubMed searches containing the term “chordoma” that address novel targeted and immunomodulatory therapeutic modalities; ongoing clinical trials involved in treating chordoma with novel therapeutic modalities identified through the Chordoma Foundation and ClinicalTrials.gov; and the authors' practice experience combined with various authoritative texts concerning the subject.

Conclusions.—
Chordoma is a clinically and histologically unique malignant neoplasm, and numerous diagnostic considerations must be excluded to establish the correct diagnosis. Treatment options have largely been centered on surgical excision with marginal results; however, novel therapeutic options including targeted therapy and immunotherapy are promising means to improve prognosis.
A genomic perspective on the potential of termite-associated Cellulosimicrobium cellulans MP1 as producer of plant biomass-acting enzymes and exopolysaccharides
Authors: Vu Nguyen Thi-Hanh , Quach Tung Ngoc , Dao Xuan Thi-Thanh , Le Ha Thanh , Le Chi Phuong , Nguyen Lam Tung , Le Lam Tung , Ngo Cuong Cao , Hoang Ha , Chu Ha Hoang , Phi Quyet-Tien 
Published: July 2021

Background
Lignocellulose is a renewable and enormous biomass resource, which can be degraded efficiently by a range of cocktails of carbohydrate-active enzymes secreted by termite gut symbiotic bacteria. There is an urgent need to find enzymes with novel characteristics for improving the conversion processes in the production of lignocellulosic-based products. Although various studies dedicated to the genus Cellulosimicrobium as gut symbiont, genetic potential related to plant biomass-acting enzymes and exopolysaccharides production has been fully untapped to date.

Methods
The cellulolytic bacterial strain MP1 was isolated from termite guts and identified to the species level by phenotypic, phylogenetic, and genomic analysis. To further explore genes related to cellulose and hemicellulose degradation, the draft genome of strain MP1 was obtained by using whole-genome sequencing, assembly, and annotation through the Illumina platform. Lignocellulose degrading enzymes and levan production in the liquid medium were also examined to shed light on bacterial activities.

Results
Among 65 isolates obtained, the strain MP1 was the most efficient cellulase producer with cellulase activity of 0.65 ± 0.02 IU/ml. The whole genome analysis depicted that strain MP1 consists of a circular chromosome that contained 4,580,223 bp with an average GC content of 73.9%. The genome comprises 23 contigs including 67 rRNA genes, three tRNA genes, a single tmRNA gene, and 4,046 protein-coding sequences. In support of the phenotypic identification, the 16S rRNA gene sequence, average nucleotide identity, and whole-genome-based taxonomic analysis demonstrated that the strain MP1 belongs to the species Cellulosimicrobium cellulans. A total of 30 genes related to the degradation of cellulases and hemicellulases were identified in the C. cellulans MP1 genome. Of note, the presence of sacC1-levB-sacC2-ls operon responsible for levan and levan-type fructooligosaccharides biosynthesis was detected in strain MP1 genome, but not with closely related C. cellulans strains, proving this strain to be a potential candidate for further studies. Endoglucanases, exoglucanases, and xylanase were achieved by using cheaply available agro-residues such as rice bran and sugar cane bagasse. The maximum levan production by C. cellulans MP1 was 14.8 ± 1.2 g/l after 20 h of cultivation in media containing 200 g/l sucrose. To the best of our knowledge, the present study is the first genome-based analysis of a Cellulosimicrobium species which focuses on lignocellulosic enzymes and levan biosynthesis, illustrating that the C. cellulans MP1 has a great potential to be an efficient platform for basic research and industrial exploitation.
Bird-window collisions: Mitigation efficacy and risk factors across two years
Authors: Brown Barbara B. , Santos Sabrina , Ocampo-Peñuela Natalia 
Published: July 2021

BackgroundResearch on bird-window collision mitigation is needed to prevent up to a billion bird fatalities yearly in the U.S. At the University of Utah campus (Salt Lake City, Utah, USA), past research documented collisions, especially for Cedar Waxwings (Bombycilla cedrorum) drawn to fruiting ornamental pears in winter. Mirrored windows, which have a metallic coating that turns window exteriors into mirrors, had frequent collisions, which were mitigated when Feather Friendly®bird deterrent markers were applied. Bird-friendly windows–ORNILUX®ultraviolet (UV) and fritted windows–also reduced collisions when data were collected across fall and winter. Extending this prior research, we evaluated additional mitigation and tested the replicability of effects for pear trees, mirrored windows, and bird-friendly windows across two years.MethodsUsing published data from eight buildings monitored for collisions in year 1 (Fall and Winter, 2019–2020), we added another year of monitoring, Fall and Winter, 2020–2021. Between years, Feather Friendly®mitigation markers were added to collision-prone areas of two buildings, including both mirrored and transparent windows.ResultsThe two buildings that received new Feather Friendly®mitigation had significantly fewer collisions post-mitigation. Control areas also had nonsignificant decline in collisions. The interaction of area (mitigation vs. control) by time (year 1 vs. 2) was significant, based on generalized estimating equations (GEE). The total yearly collisions across all eight buildings declined from 39 to 23. A second GEE analysis of all 8 buildings showed that mirrored windows, pear trees, and bird-friendly windows were each significant when analyzed separately. The best-fit model showed more collisions for mirrored windows and fewer collisions for bird-friendly windows. We found pear tree proximity to be related to more collisions in winter than fall. In addition, pear trees showed reduced collisions from year 1 to 2, consistent with new mitigation for two of three buildings near pear trees.DiscussionFeather Friendly® markers can mitigate collisions with transparent windows, not only mirrored windows, compared to unmitigated areas over 2 years. Results also underscore the dangers of pear tree proximity and mirrored windows and the efficacy of bird-friendly windows. Thus, bird collisions can be prevented by window mitigation, permanent bird-friendly windows, and landscape designs that avoid creating ecological traps.
A Construction Technique for Group Divisible (v-1,k,0,1) Partially Balanced Incomplete Block Designs (PBIBDs)
Authors: Otekunrin Oluwaseun A. , Alawode Kehinde O. 
Published: July 2021

Group Divisible PBIBDs are important combinatorial structures with diverse applications. In this paper, we provided a construction technique for Group Divisible (v-1,k,0,1) PBIBDs. This was achieved by using techniques described in literature to construct Nim addition tables of order 2n, 2≤n≤5 and (k2,b,r,k,1)Resolvable BIBDs respectively. A “block cutting” procedure was thereafter used to generate corresponding Group Divisible (v-1,k,0,1) PBIBDs from the (k2,b,r,k,1)Resolvable BIBDs. These procedures were streamlined and implemented in MATLAB. The generated designs are regular with parameters(15,15,4,4,5,3,0,1);(63,63,8,8,9,7,0,1);(255,255,16,16,17,15,0,1) and (1023,1023,32,32,33,31,0,1). The MATLAB codes written are useful for generating the blocks of the designs which can be easily adapted and utilized in other relevant studies. Also, we have been able to establish a link between the game of Nim and Group Divisible (v-1,k,0,1) PBIBDs.
Humoral response to neurofilaments and dipeptide repeats in ALS progression
Authors: Puentes Fabiola , Lombardi Vittoria , Lu Ching‐Hua , Yildiz Ozlem , Fratta Pietro , Isaacs Adrian , Bobeva Yoana , Wuu Joanne ,   ALS Biomarker Consortium,   CReATe Consortium, Benatar Michael , Malaspina Andrea 
Published: July 2021

AbstractObjectiveTo appraise the utility as biomarkers of blood antibodies and immune complexes to neurofilaments and dipeptide repeat proteins, the products of translation of the most common genetic mutation in amyotrophic lateral sclerosis (ALS).MethodsAntibodies and immune complexes against neurofilament light, medium, heavy chains as well as poly‐(GP)‐(GR) dipeptide repeats were measured in blood samples from the ALS Biomarkers (n = 107) and the phenotype–genotype biomarker (n = 129) studies and in 140 healthy controls. Target analyte levels were studied longitudinally in 37 ALS cases. Participants were stratified according to the rate of disease progression estimated before and after baseline and C9orf72 genetic status. Survival and longitudinal analyses were undertaken with reference to matched neurofilament protein expression.ResultsCompared to healthy controls, total neurofilament proteins and antibodies, neurofilament light immune complexes (p < 0.0001), and neurofilament heavy antibodies (p = 0.0061) were significantly elevated in ALS, patients with faster progressing disease (p < 0.0001) and in ALS cases with a C9orf72 mutation (p < 0.0003). Blood neurofilament light protein discriminated better ALS from healthy controls (AUC: 0.92; p < 0.0001) and faster from slower progressing ALS (AUC: 0.86; p < 0.0001) compared to heavy‐chain antibodies and light‐chain immune complexes (AUC: 0.79; p < 0.0001 and AUC: 0.74; p < 0.0001). Lower neurofilament heavy antibodies were associated with longer survival (Log‐rank Chi‐square: 7.39; p = 0.0065). Increasing levels of antibodies and immune complexes between time points were observed in faster progressing ALS.ConclusionsWe report a distinctive humoral response characterized by raising antibodies against neurofilaments and dipeptide repeats in faster progressing and C9orf72 genetic mutation carriers ALS patients. We confirm the significance of plasma neurofilament proteins in the clinical stratification of ALS.
Antiperovskite Gd3SnC: Unusual Coexistence of Ferromagnetism and Heavy Fermions in Gd Lattice
Authors: Bang Joonho , Park Jongho , Lee Kimoon , Kim Minsoo , Kyung Wonshik , Denlinger Jonathan D. , Kim Yeongkwan , Lee Young Hee , Kim Changyoung , Kim Sung Wng 
Published: July 2021

AbstractInverted structures of common crystal lattices, referred to as antistructures, are rare in nature due to their thermodynamic constraints imposed by the switched cation and anion positions in reference to the original structure. However, a stable antistructure formed with mixed bonding characters of constituent elements in unusual valence states can provide unexpected material properties. Here, a heavy‐fermion behavior of ferromagnetic gadolinium lattice in Gd3SnC antiperovskite is reported, contradicting the common belief that ferromagnetic gadolinium cannot be a heavy‐fermion system due to the deep energy level of localized 4f‐electrons. The specific heat shows an unusually large Sommerfeld coefficient of ≈1114 mJ mol−1 K−2 with a logarithmic behavior of non‐Fermi‐liquid state. It is demonstrated that the heavy‐fermion behavior in the non‐Fermi‐liquid state appears to arise from the hybridized electronic states of gadolinium 5d‐electrons participating in metallic GdGd and covalent GdC bonds. These results accentuate the unusual chemical bonds in CGd6 octahedra with the dual characters of gadolinium 5d‐electrons for the emergence of heavy fermions.
Thermostability of Measles and Rubella Vaccines in a Microneedle Patch
Authors: Joyce Jessica C. , Collins Marcus L. , Rota Paul A. , Prausnitz Mark R. 
Published: July 2021

AbstractMeasles and rubella vaccinations are highly effective at reducing disease prevalence; however, logistic issues related to subcutaneous administration and vaccine wastage limit the extent of vaccination coverage. Microneedle (MN) patches can increase coverage by easing logistics through simplified administration and improved stability. This study demonstrates the thermostability of a bivalent measles and rubella vaccine MN patch. The data show that rubella vaccine stability requires pH buffering during drying; potassium phosphate buffer at neutral pH is optimal for both vaccines. Screening 43 excipients for their ability to retain potency during drying and storage yields sucrose‐threonine‐potassium phosphate buffer formulation at pH 7.5 as an optimal formulation. MN patches made with this formulation have no significant loss of vaccine titer after 1 month and remain within a one log10 titer loss cutoff after 3–4 months at 5, 25, and 40 °C. Finally, these patches are shown to be immunogenic in juvenile rhesus macaques. This work demonstrates the potential for MN patches for measles and rubella vaccination to be removed from the cold chain, which is expected to decrease vaccine cost and wastage, and increase vaccination coverage.
Mentoring in the Time of COVID‐19: An Analysis of Online Focus Groups with Mentors to Youth
Authors: Kaufman Michelle R. , Wright Kate , Simon Jeannette , Edwards Giselle , Thrul Johannes , DuBois David L. 
Published: July 2021

AbstractThis study explored the experiences of mentors to youth during the early months of the COVID‐19 pandemic. The study aims were to examine (1) the role of the pandemic on mentor–mentee interactions and relationships and (2) the ways in which mentors could be supported during the health crisis to better meet youth needs. Six online focus groups were conducted with 39 mentors. Mentor participants included 26 females and 11 males (two did not disclose gender), and 51% identified as white. Any mentor currently in a mentoring relationship, regardless of type, was eligible. Using Facebook groups, moderators posted questions and prompts, and mentor participants responded using textual comments. The text from each group was recorded, extracted, and coded and analyzed using thematic analysis. As mentors transitioned to a primarily online format, text and video chat became the most common communication methods. Mentees’ access to technology and privacy were the biggest challenges faced. Mentor concerns for their mentees varied, including mental health, school, family finances, and access to instrumental support and food. Mentor help involved routinely connecting with mentees and providing academic support. Mentors requested ideas and resources for connecting with mentees and an online mentor support group. During the early weeks of the pandemic, mentors continued to engage with mentees, offering valuable support during a confusing and scary time. Mentoring programs can broaden their approach, intentionally integrating online connecting in an effort to provide safe, appropriate, and continued support to both mentors and mentees.
Robust joint modelling of longitudinal and survival data: Incorporating a time‐varying degrees‐of‐freedom parameter
Authors: McFetridge Lisa M. , Asar Özgür , Wallin Jonas 
Published: July 2021

AbstractMonitoring of individual biomarkers has the potential of explaining the hazard of survival outcomes. In practice, these measurements are intermittently observed and are known to be subject to substantial measurement error. Joint modelling of longitudinal and survival data enables us to associate intermittently measured error‐prone biomarkers with risks of survival outcomes and thus plays an important role in the analysis of medical data. Most of the joint models available in the literature have been built on the Gaussian assumption. This makes them sensitive to outliers. In this work, we study a range of robust models to address this issue. Of particular interest is the common occurrence in medical data that outliers can occur with different frequencies over time, for example, in the period when patients adjust to treatment changes. Motivated by the analysis of data gathered from patients with primary biliary cirrhosis, a new model with a time‐varying robustness is introduced. Through both the motivating example and a simulation study, this research not only stresses the need to account for longitudinal outliers in the analysis of medical data and in joint modelling research but also highlights the bias and inefficiency from not properly estimating the degrees‐of‐freedom parameter. This work presents a number of methods in addition to the time‐varying robustness, and each method can be fitted using the R package robjm.
RNA editing affects cis‐regulatory elements and predicts adverse cancer survival
Authors: Wu Yuan‐Ming , Guo Yan , Yu Hui , Guo Tao 
Published: July 2021

AbstractBackgroundRNA editing exerts critical impacts on numerous biological processes and thus are implicated in crucial human phenotypes, including tumorigenesis and prognosis. While previous studies have analyzed aggregate RNA editing activity at the sample level and associated it with overall cancer survival, there is not yet a large‐scale disease‐specific survival study to examine genome‐wide RNA editing sites’ prognostic value taking into account the host gene expression and clinical variables.MethodsIn this study, we solved comprehensive Cox proportional models of disease‐specific survival on individual RNA‐editing sites plus host gene expression and critical demographic covariates. This allowed us to interrogate the prognostic value of a large number of RNA‐editing sites at single‐nucleotide resolution.ResultsAs a result, we identified 402 gene‐proximal RNA‐editing sites that generally predict adverse cancer survival. For example, an RNA‐editing site residing in ZNF264 indicates poor survival of uterine corpus endometrial carcinoma, with a hazard ratio of 2.13 and an adjusted p‐value of 4.07 × 10−7. Some of these prognostic RNA‐editing sites mediate the binding of RNA binding proteins and microRNAs, thus propagating their impacts to extensive regulatory targets.ConclusionsIn conclusion, RNA editing affects cis‐regulatory elements and predicts adverse cancer survival.