bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quiet-Filament Eruptions and Coronal Jets as Causes of Depressions in Microwave Radio Emission
Authors: Kuzmenko I. V. 
Published: December 2021

AbstractSeveral solar events with different types of negative microwave bursts have been studied using data from different spectral ranges. The total radio flux data obtained at the Ussuriysk Observatory, the Nobeyama Observatory, the US Air Force Radio Solar Telescope Network (RSTN), and the spectropolarimeter of the Institute of Solar–Terrestrial Physics, Siberian Branch of the Russian Academy of Sciences (ISTP SB RAS) were used. The images were analyzed using data from the SDO/AIA space observatory in the 304 Å channel and the Nobeyama radio heliograph at a frequency of 17 GHz. It was shown that the “isolated” depressions of radio emission were caused by the absorption of radiation from radio sources and/or vast regions of the quiet Sun by low-temperature material of a large eruptive filament in the absence of flares. This confirmed the conclusions of the previous studies. It was revealed that the cause of negative bursts of the “pre-burst depression” type was the screening of a near-limb radio source by the material of coronal jets. In the case of a weak flare accompanying the jet, the negative burst could also be of the “isolated” type. A case of a previously unreported occurrence of a deeper depression of radio emission at high frequencies as compared to low frequencies was considered. It was shown that negative bursts are not as rare phenomena as previously thought.
Cost–utility analysis of antimicrobial stewardship programme at a tertiary teaching hospital in Ethiopia
Authors: Gebretekle Gebremedhin Beedemariam , Mariam Damen Haile , Mac Stephen , Abebe Workeabeba , Alemayehu Tinsae , Degu Wondwossen Amogne , Libman Michael , Yansouni Cedric P , Fenta Teferi Gedif , Semret Makeda , Sander Beate 
Published: December 2021

ObjectiveAntimicrobial stewardship (AMS) significantly reduces inappropriate antibiotic use and improves patient outcomes. In low-resource settings, AMS implementation may require concurrent strengthening of clinical microbiology capacity therefore additional investments. We assessed the cost-effectiveness of implementing AMS at Tikur Anbessa Specialised Hospital (TASH), a tertiary care hospital in Ethiopia.DesignWe developed a Markov cohort model to assess the cost–utility of pharmacist-led AMS with concurrent strengthening of laboratory capacity compared with usual care from a ‘restricted societal’ perspective. We used a lifetime time horizon and discounted health outcomes and cost at 3% annually. Data were extracted from a prospective study of bloodstream infections among patients hospitalised at TASH, supplemented by published literature. We assessed parameter uncertainty using deterministic and probabilistic sensitivity analyses.SettingTertiary care hospital in Ethiopia, with 800 beds and serves over half a million patients per year.PopulationCohort of adults and children inpatient population aged 19.8 years at baseline.InterventionLaboratory-supported pharmacist-led AMS compared with usual care. Usual care is defined as empirical initiation of antibiotic therapy in the absence of strong laboratory and AMS.Outcome measuresExpected life-years, quality-adjusted life-years (QALYs), costs (US$2018) and incremental cost-effectiveness ratio.ResultsLaboratory-supported AMS strategy dominated usual care, that is, AMS was associated with an expected incremental gain of 38.8 QALYs at lower expected cost (incremental cost savings:US$82 370) per 1000 patients compared with usual care. Findings were sensitive to medication cost, infection-associated mortality and AMS-associated mortality reduction. Probabilistic sensitivity analysis demonstrated that AMS programme was likely to be cost-effective at 100% of the simulation compared with usual care at 1%–51% of gross domestic product/capita.ConclusionOur study indicates that laboratory-supported pharmacist-led AMS can result in improved health outcomes and substantial healthcare cost savings, demonstrating its economic advantage in a tertiary care hospital despite greater upfront investments in a low-resource setting.
Vitamin D supplementation in chronic spinal cord injury (VitD-SCI): study protocol for a randomised controlled trial
Authors: Hertig-Godeschalk Anneke , Brinkhof Martin W G , Scheel-Sailer Anke , Perret Claudio , Jenny Andreas , Landmann Gunter , Wyss Patrik O , Flueck Joelle Leonie 
Published: December 2021

IntroductionVitamin D insufficiency, a vitamin D status or serum 25(OH)D concentration of ≤75 nmol/L, is highly prevalent in individuals with a spinal cord injury (SCI). Vitamin D is important for the functioning of the musculoskeletal, immune and respiratory systems, which are relevant determinants of secondary health conditions in SCI. An insufficiency should be treated with vitamin D supplementation. However, there is a lack of evidence regarding the optimal dosage and duration of vitamin D supplementation for individualised and long-term management of the vitamin D status in the context of SCI. This paper presents the protocol for the vitamin D supplementation in chronic spinal cord injury (VitD-SCI) trial that aims to investigate the effect of a 12-month intake of vitamin D supplementation on vitamin D status as well as on several secondary parameters among individuals with a chronic SCI.Methods and analysesThe VitD-SCI trial is a randomised, placebo-controlled, double-blinded, parallel-group, superiority trial, conducted at the Swiss Paraplegic Centre. A total of 45 participants living with an SCI for at least 3 years (chronic SCI) and a vitamin D insufficiency at the first study visit, will be randomly assigned to one of three intervention groups. Participants receive either a monthly dosage of 24 000 IU or 48 000 IU vitamin D or a placebo for 12 months. Measurements taking place every 3 months include the assessment of vitamin D status (primary outcome) as well as bone mineral density, handgrip strength, fatigue, mood, pain and pressure injuries (secondary outcomes). Safety and tolerance of vitamin D supplementation will also be evaluated.Ethics and disseminationThe Swiss Ethics Committee for Northwest/Central Switzerland (EKNZ, 2020–01493) and the Swiss Agency for Therapeutic Products (Swissmedic, 2020DR3150) approved this study. Findings will be disseminated through peer-reviewed publications.Trial registration numbersNCT04652544and SNCTP000004032.
Reversal of pancreatic desmoplasia by a tumour stroma-targeted nitric oxide nanogel overcomes TRAIL resistance in pancreatic tumours
Authors: Huang Hsi-Chien , Sung Yun-Chieh , Li Chung-Pin , Wan Dehui , Chao Po-Han , Tseng Yu-Ting , Liao Bo-Wen , Cheng Hui-Teng , Hsu Fu-Fei , Huang Chieh-Cheng , Chen Yi-Ting , Liao Yu-Hui , Hsieh Hsin Tzu , Shih Yu-Chuan , Liu I-Ju , Wu Han-Chung , Lu Tsai-Te , Wang Jane , Chen Yunching 
Published: December 2021

ObjectiveStromal barriers, such as the abundant desmoplastic stroma that is characteristic of pancreatic ductal adenocarcinoma (PDAC), can block the delivery and decrease the tumour-penetrating ability of therapeutics such as tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), which can selectively induce cancer cell apoptosis. This study aimed to develop a TRAIL-based nanotherapy that not only eliminated the extracellular matrix barrier to increase TRAIL delivery into tumours but also blocked antiapoptotic mechanisms to overcome TRAIL resistance in PDAC.DesignNitric oxide (NO) plays a role in preventing tissue desmoplasia and could thus be delivered to disrupt the stromal barrier and improve TRAIL delivery in PDAC. We applied an in vitro–in vivo combinatorial phage display technique to identify novel peptide ligands to target the desmoplastic stroma in both murine and human orthotopic PDAC. We then constructed a stroma-targeted nanogel modified with phage display-identified tumour stroma-targeting peptides to co-deliver NO and TRAIL to PDAC and examined the anticancer effect in three-dimensional spheroid cultures in vitro and in orthotopic PDAC models in vivo.ResultsThe delivery of NO to the PDAC tumour stroma resulted in reprogramming of activated pancreatic stellate cells, alleviation of tumour desmoplasia and downregulation of antiapoptotic BCL-2 protein expression, thereby facilitating tumour penetration by TRAIL and substantially enhancing the antitumour efficacy of TRAIL therapy.ConclusionThe co-delivery of TRAIL and NO by a stroma-targeted nanogel that remodels the fibrotic tumour microenvironment and suppresses tumour growth has the potential to be translated into a safe and promising treatment for PDAC.
Phase transition in the bipartite z-matching
Authors: Kahlke Till , Fränzle Martin , Hartmann Alexander K. 
Published: December 2021

AbstractWe study numerically the maximumz-matching problems on ensembles of bipartite random graphs. Thez-matching problems describes the matching between two types of nodes,usersandservers, where each server may serve up tozusers at the same time. Using a mapping to standard maximum-cardinality matching, and because for the latter there exists a polynomial-time exact algorithm, we can study large system sizes of up to$$10^6$$106nodes. We measure the capacity and the energy of the resulting optimum matchings. First, we confirm previous analytical results for bipartite regular graphs. Next, we study the finite-size behaviour of the matching capacity and find the same scaling behaviour as before for standard matching, which indicates the universality of the problem. Finally, we investigate for bipartite Erdős–Rényi random graphs the saturability as a function of the average degree, i.e. whether the network allows as many customers as possible to be served, i.e. exploiting the servers in an optimal way. We find phase transitions between unsaturable and saturable phases. These coincide with a strong change of the running time of the exact matching algorithm, as well with the point where a minimum-degree heuristic algorithm starts to fail.Graphical Abstract
Introduction to the volume, and definition and use of the term ‘tectono-sedimentary element’
Authors: Drachev Sergey S. , Brekke Harald , Henriksen Erik , Moore Thomas 
Published: December 2021

Abstract
The present volume is rooted in a map of sedimentary successions of the Arctic Region by Grantz et al. (2011), and contains a brief, but comprehensive compilation of geological and geophysical data characterizing all significant sedimentary successions in the Arctic, which cover 57% of the polar area north of 64°N. Two main goals have been designated: (i) to provide, based on the present-day knowledge and data, a characterization of all Arctic sedimentary successions (or sedimentary accumulations), and (ii) to supply a snapshot of hydrocarbon-related exploration in the Arctic at the end of the second decade of this millennium. To achieve these goals, we represent sedimentary successions as consisting of one or several “Tectono-Sedimentary Elements” (TSE). This concept allows delineation, mapping, and characterization of 9 categories of TSEs based of main tectonic regimes that formed accommodation space.
A TSE characterization template has been developed as an efficient method of organising and presenting the most important information about stratigraphy, structure, and petroleum geology of a TSE, including most significant exploration facts. This organizational architecture is the backbone of the volume and is a key feature that distinguishes it from other similar works about the sedimentary basins.
Model-Based Characterization of the Bidirectional Interaction Between Pharmacokinetics and Tumor Growth Dynamics in Patients with Metastatic Merkel Cell Carcinoma Treated with Avelumab
Authors: Grisic Ana-Marija , Xiong Wenyuan , Tanneau Lénaïg , Jönsson Siv , Friberg Lena E. , Karlsson Mats O. , Dai Haiqing , Zheng Jenny , Girard Pascal , Khandelwal Akash 
Published: December 2021

Abstract

Purpose:
Empirical time-varying clearance models have been reported for several immune checkpoint inhibitors, including avelumab (anti–programmed death ligand 1). To investigate the exposure-response relationship for avelumab, we explored semimechanistic pharmacokinetic (PK)–tumor growth dynamics (TGD) models.

Patients and Methods:
Plasma PK data were pooled from three phase I and II trials (JAVELIN Merkel 200, JAVELIN Solid Tumor, and JAVELIN Solid Tumor JPN); tumor size (TS) data were collected from patients with metastatic Merkel cell carcinoma (mMCC) enrolled in JAVELIN Merkel 200. A PK model was developed first, followed by TGD modeling to investigate interactions between avelumab exposure and TGD. A PK-TGD feedback loop was evaluated with simultaneous fitting of the PK and TGD models.

Results:
In total, 1,835 PK observations and 338 TS observations were collected from 147 patients. In the final PK-TGD model, which included the bidirectional relationship between PK and TGD, avelumab PK was described by a two-compartment model with a positive association between clearance and longitudinal TS, with no additional empirical time-varying clearance identified. TGD was described by first-order tumor growth/shrinkage rates, with the tumor shrinkage rate decreasing exponentially over time; the exponential time-decay constant decreased with increasing drug concentration, representing the treatment effect through tumor shrinkage inhibition.

Conclusions:
We developed a TGD model that mechanistically captures the prevention of loss of antitumor immunity (i.e., T-cell suppression in the tumor microenvironment) by avelumab, and a bidirectional interaction between PK and TGD in patients with mMCC treated with avelumab, thus mechanistically describing previously reported time variance of avelumab elimination.
Masked Violence
Authors: Stacy Ivan 
Published: December 2021

Abstract
This article examines the carnivalesque in two recent Bhutanese films, Hema Hema: Sing Me a Song While I Wait (2016, dir. Khyentse Norbu) and The Red Phallus (2018, dir. Tashi Gyeltshen). Bhutanese Buddhist rituals contain a number of elements that bear striking parallels with Mikhail Bakhtin’s conception of the carnivalesque, most notably in the use of masks and in the presence of jester figures known as atsaras. However, important differences also exist, most importantly the fact that in Bhutanese rituals masks are held to be sacred and are worn during dances intended to bring both participants and audience closer to Buddhist enlightenment. In both films discussed in this article, the anonymity provided by these traditional and ostensibly sacred masks prompts acts of sexual violence. As such, the article argues that the content of both films questions the use of ritual in contemporary Bhutan, while the use of carnivalesque form acts to deepen the nature of that questioning. In the case of Hema Hema, this is achieved by removing barriers between performance and spectatorship, while The Red Phallus in contrast seeks to alienate its audience.
“Extra-Special Care”
Authors: Colombo Gabriel Miller 
Published: December 2021

Abstract
This paper reads Wes Anderson’s 2014 film The Grand Budapest Hotel through the lens of liturgical theology. It proposes that by revivifying collective memory—both its tragedies and joys—in a rhythmic, sensory, spatial, playful, and paradoxical way, the film forms our “social imaginary” for the better. In exploring the resonances between existing Anderson scholarship and liturgical theology, the paper highlights three key facets of the film: its implication of the present through the mythical stylization of the past; the relationship between M. Gustave and Zero, who find their place together as priest and acolyte of the Grand Budapest Hotel, enacting its liturgy of service against the rising tide of barbarism; and Anderson’s formal and aesthetic vision, which curates and elevates “found” objects and spaces, recognizing them as sacramental. Rejecting metaphysical dualism, the film suggests that communion and mystery are embedded in and enlivened by the material world.
Dynamics of Normative Change for International Nuclear Export Controls
Authors: Kim Lami 
Published: December 2021

Abstract
Like other normative systems, the international nuclear export control norms are incomplete and at times contradictory. Thus, contestations to the international nuclear export control norms inevitably emerge, as they did in the wake of the 1974 Indian nuclear test and the 1991 discovery of Iraq’s nuclear weapons program. These two nuclear crises prompted intense debates regarding the adequacy of the existing norms. The outcome of the debates generated overwhelming agreement and action among nuclear suppliers that they required strengthening. Drawing on Wayne Sandholtz’s theory of normative change, which argues that events trigger disputes whose outcomes modify norms, this article illustrates how the nuclear export control norms have evolved in a cyclical fashion. The article aims to contribute to the constructivist literature on normative change and discusses policy implications.
European Strategic Autonomy: The Test Case of Iran
Authors: Lohmann Sascha 
Published: December 2021

Abstract
The ideal of the European Union (EU) as a global peace and security actor is increasingly clashing with the reality of a multipolar world defined by militarised conflict, and a loosening of the formerly close trans-Atlantic relationship with the United States. European policy-makers have identified strategic autonomy as a possible remedy in the face of a growing number of internal and external security threats. This paper adds to the conceptualisation of strategic autonomy by contextualising its current usage and political genealogy. Empirically, European strategic autonomy is examined concerning the efforts to preserve the Iranian nuclear deal after the Trump administration had ceased US participation in May 2018. In particular, the paper assesses the European response to counter the re-imposed unilateral United States (US) sanctions against European individuals and entities by updating the so-called blocking regulation, and setting up a special purpose vehicle (spv) for facilitating trade with Iran. The results show that the European struggle toward achieving strategic autonomy has largely failed, but that it holds valuable lessons to approximate this ideal in the future.
International Refugee Law in Crisis: Islands, Incarceration and Neo-Refoulement during COVID-19
Authors: Hambly Jessica 
Published: December 2021

Abstract
Attempts by states to deter refugee movement have evolved to a point that routine and systematic breach of non-refoulement and associated human rights frequently constitutes a central pillar in their asylum architectures. The expansion of state policies and practices under which people seeking asylum are prevented from reaching safe places and lodging asylum claims has accelerated during the Covid-19 pandemic. Drawing on examples from Australia and Europe, this article uses neo-refoulement—a concept introduced by geographers Jennifer Hyndman and Alison Mountz—to signal not only the rise in pushbacks at land and sea borders, but also practices that occur well within the boundaries of sovereign territory. These include the use of island incarceration, fast-track border procedures, and denial of legal presence on sovereign territory, even where physical presence is achieved. Such measures have often been introduced under the pretext of responding to situations of ‘mass influx’. And yet, far from providing an adequate response to a so-called ‘refugee crisis’, they serve only to facilitate a greater humanitarian crisis.
State Responsibility, International Law and the COVID-19 Crisis
Authors: Heathcote Sarah 
Published: December 2021

Abstract
Disruptions caused by the global spread of COVID-19 have generated different types of responsibility claims at both the domestic and international levels. Alleged breaches of the law have resulted from the immediate reactions to the pandemic’s emergence and spread, as well as from less proximate adjustments made to the ongoing crisis. This contribution begins by briefly surveying the types of responsibility relevant to the crisis with a view to identifying systemic legal issues, particularly at the international level. It then focusses on the law of state responsibility for internationally wrongful acts, not to resolve the various claims that are or can be made, but in order to identify what this crisis reveals about the trends in the law of responsibility, the opportunities for its invocation, and indeed, state tactics in engaging with this body of law. Just as the pandemic has been revelatory of social trends, so too it has highlighted trends in the law and its operation.
Intraseasonal Variability of Upper-Ocean Heat Fluxes in the Central Bay of Bengal
Authors: Wijesekera Hemantha W. , Teague W. J. , Wang David W. , Hallock Z. R. , Luecke Conrad A. , Jarosz Ewa , Fernando H. J. S. , Jinadasa S. U. P. , Jensen Tommy G. , Rydbeck Adam , Flatau Maria 
Published: December 2021

AbstractUpper-ocean heat content and heat fluxes of 10–60-day intraseasonal oscillations (ISOs) were examined using high-resolution currents and hydrographic fields measured at five deep-water moorings in the central Bay of Bengal (BoB) and satellite observations as part of an international effort examining the role of the ocean on monsoon intraseasonal oscillations (MISOs) in the BoB. Currents, temperature, and salinity were sampled over the upper 600–1200 m from July 2018 to June 2019. The 10–60-day velocity ISOs of magnitudes 20–30 cm s−1were observed in the upper 200 m, and temperature ISOs as large as 3°C were observed in the thermocline near 100 m. The wavelet cospectral analysis reveals multiple periods of ISOs carrying heat southward. The meridional heat-flux divergence associated with the 10–60-day band was strongest in the central BoB at depths between 40 and 100 m, where the averaged flux divergence over the observational period is as large as 10−7°C s−1. The vertically integrated heat-flux divergence in the upper 200 m is about 20–30 W m−2, which is comparable to the annual-average net surface heat flux in the northern BoB. Correlations between the heat content over the 26°C isotherm and the outgoing longwave radiation indicate that the atmospheric forcing typically leads changes of the oceanic heat content, but in some instances, during fall–winter months, oceanic heat content leads the atmospheric convection. Our analyses suggest that ISOs play an important role in the upper-ocean heat balance by transporting heat southward, while aiding the air–sea coupling at ISO time scales.