bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulation of Follicular Atresia by WIP1-Mediated Apoptosis and Autophagy
Authors: Zhou Su , Xi Yueyue , Chen Yingying , Yan Wei , Wu Meng , Li Milu , Wu Tong , Zhang Jinjin , Shen Wei , Luo Aiyue , Wang Shixuan 
Published: August 2021

Abstract
Female endocrine homeostasis and reproductive success depend on the number and quality of follicles. The follicle is the basic functional unit within mammalian ovaries. Excessive follicular atresia is responsible for the accelerated ovarian aging process. Therefore, exploring the molecular mechanism of follicle development and atresia is essential for protecting ovarian function. In this study, we interrogate the striking correlation between follicular atresia and wild-type p53-induced phosphatase 1 (WIP1) expression in mouse ovaries to understand how WIP1 phosphatase activity regulates follicle development. WIP1 is mainly expressed in granulosa cells of healthy growing follicles, and atretic follicles exhibit significantly weaker WIP1 expression compared with the healthy ones. Our in vivo study indicates that inhibition of WIP1 phosphatase activity causes endocrine disorder, fertility decline and decreased ovarian reserve by triggering excessive follicular atresia through promoting autophagy and apoptosis. By in vitro follicle culture, we determine that inhibiting the WIP1 activity impairs the follicle development, causing more follicular atresia and decreased oocyte quality. Besides, downregulating WIP1 expression in granulosa cells in vitro also promotes apoptosis and autophagy via WIP1-p53 and WIP1-mTOR signal pathway. Our findings from the in vitro and in vivo experiments revealed that appropriate Wip1 expression is required for follicle development. Downregulation of WIP1 expression accelerates follicle atresia via WIP1-p53 and WIP1-mTOR signal pathway related apoptosis and autophagy. It is speculated that moderate up-regulation of WIP1 expression may help delaying the decline of ovarian reserve.
Rapid brain atrophy after COVID-19 encephalitis;Disintegrata Furiosa!
Authors: MARAMATTOM BOBY VARKEY , Rao Tejaswi 
Published: August 2021

Abstract
Objectives: We had a patient with COVID-19 encephalitis who demonstrated striking brain atrophy on 3 MRI scans 60 days apart. We aimed to quantify the volume loss and brain atrophy. This is the first report that quantifies brain atrophy with COVID encephalitis.Methods: A 75 year old partially vaccinated man with COVID encephalitis underwent 3 serial MRI scans. Manual volumetry using PACS software was used to average and quantify brain atrophy between the three scans.Results: In 60 days, our patient had approximately 11.52 % (117 ml) of forebrain atrophy, which corresponded to 78 years of accelerated aging. Cerebellar atrophy of 6.2% (7.7 cc) was also noted. Discussion: We have demonstrated striking brain atrophy with COVID encephalitis. Brain involvement and atrophy or connectome disruptions might contribute to post COVID cognitive impairment. Serial MRI scans after COVID-19 and volumetric analysis may detect post COVID brain atrophy as a cause of cognitive dysfunction.
Covid-19 meets game theory: a proposed experiment
Authors: Stamatopoulos Giorgos 
Published: August 2021

Abstract
Researchers around the globe are searching for a "combo-drug" against Covid-19 by trying to combine various existing drugs. Given a set of such drugs, various algorithms (based, for example, on artificial intelligence) are used to identify the efficacy of different shares of the constituent drugs in the combo-drug. Namely, the relative weight of each drug in a "cooperative" scheme of therapy is sought-after. In the current note we propose to identify these weights using the theory of cooperative games, and in particular the Shapley value, one of the fundamental solution concepts of such games. We derive the weight of each drug by its (normalized) average marginal contribution over all possible "coalitions" of drugs it is used with, where a drug's marginal contribution to a coalition is defined as the increase in the coalition's probability to act against a virus should the drug become its "member". Hence we endow each drug with a consistent measure of significance (which is due to the consistency that Shapley value is associated with). At a theoretical level, we build the cooperative game, and compute the Shapley values, within a milestone model in drug combination theory, the Bliss independence model. At a practical level, the predictions of our game-theoretic model can be tested by using in-vitro experiments, namely experiments that are conducted in test tubes.
Interactive influence of climate variability and land-use change on blue and green water resources: a case study from the Ganjiang River Basin, China
Authors: Li Wenting , Yang Xiaoli , Ren Liliang , Lin Qianguo , Zhou Xiong , Gu Yujiao 
Published: August 2021

Abstract
The response of blue and green water to climate and land-use change in the Ganjiang River Basin (GRB) is evaluated via the SWAT model that combines three scenarios (the land-use/land-cover (LULC), climate change, and integrated climate and LULC change scenarios) in the 2040s (2031–2050) and 2060s (2051–2070). The results indicate that, for the GRB, cropland, woodland, and grassland show a decreasing trend, while build-up and water areas show an increasing trend in terms of future land-use change. The climatic conditions projected using NORESM1-M model data under the RCP4.5 and RCP8.5 scenarios suggest, respectively, increases in precipitation (31.17 and 27.24 mm), maximum temperature (2.25 and 2.69 °C), and minimum temperature (1.96 and 2.58 °C). Under climate change conditions, blue water is estimated to decrease by up to 16.89 and 21.4 mm under RCP4.5 and RCP8.5, while green water is estimated to increase up to 19.14 and 20.22 mm, respectively. Under the LULC changes, blue water is projected to increase by up to 5.50 and 7.57 mm, while green water shows decreases of 4.05 and 7.80 mm for the LULC2035 and LULC2055 scenarios, respectively. Under the four combined LULC and climate change conditions (RCP4.5_2040s, RCP4.5_2060s, RCP8.5_2040s, and RCP8.5_2060s), blue water tends to decrease by 0.67, 7.47, 7.28, and 9.99 mm, while green water increases by 19.24, 20.8, 13.87, and 22.30 mm. The influence of climate variation on blue and green water resources is comparatively higher than that of the integrated impacts of climate and land-use changes. The results of this study offer a scientific reference for the water resources management and planning department responsible for scheduling water resource management plan in the GRB.
High Sensitivity C-reactive Protein in Patients with Coronary Artery in-stent Restenosis: A Case-control Study
Authors: Ismail Hussein M. , Abaza Ahmed O. , Nasr Gamela M. , Hegazy Hesham 
Published: August 2021

Background:Inflammation plays a pivotal role in the pathogenesis of In-Stent Restenosis (ISR). High sensitivity C-reactive protein (hsCRP) is positively associated with major cardiovascular events.Aim:We aimed to investigate the hsCRP inflammatory response to Percutaneous Coronary Intervention (PCI) in Coronary Artery Disease (CAD) patients with coronary ISRvs.patients without ISR.Methods:This case-control study included 80 CAD patients previously treated with drug-eluting stent (DES) implantation. Patients had Coronary Angiography (CAG) because of chest pain or equivalent symptoms and were subdivided into 2 groups. Group A (n=40) included CAD patients with ISR. Group B (n=40) included age and gender-matched controls with CAD but without ISR. Serum hsCRP levels were obtained before PCI (baseline) and 8, 16, 24 h post-PCI.Results:At baseline (before intervention/CAG), the hsCRP level was increased in the ISR group compared with the No-ISR group (p=0.007). There were 36 (90%) patients in the ISR group who had a high hsCRP (>3 mg/L) compared with 25 (62.5%) patients in the No-ISR group. Also, there was a significant relationship between high hsCRP and the ISR. Patients with ISR had higher frequencies and percentages of elevated CRP than the no-ISR control group. This difference was maintained for all measurements, baseline, after 8, 16, and 24 h (p<0.05). Repeated measures analysis of variance (ANOVA) in the ISR group revealed that mean hsCRP differed significantly between serial measurements (p<0.001). In contrast, in the control group, the mean hsCRP did not differ significantly between the serial measurements (p=0.65).Most of our patients (n=66, 82.5%) had 1-vessel CAD disease, and the left anterior descending (LAD) coronary artery was significantly affected in 46 patients (57.5%). Management of restenosis was accomplished mainly by stenting by DES in 29 patients (72.5%).Conclusion:Patients with ISR had substantially higher pre- and post-PCI hsCRP levels than the no-ISR controls. This difference was maintained up to 24h post-PCI. Conversely, the mean hsCRP did not significantly differ at the follow-up points for the controls without ISR.
Intoxications by lead and its inorganic compounds
Authors: Tkachyshyn V.S. 
Published: August 2021

Lead belongs to the group of blood poisons that impair the synthesis of porphyrins and heme. Under industrial conditions, only chronic lead poisoning can develop. Lead belongs to the poisons that have the effect of material cumulation. The half-life of lead is 20 years. Once in the body, it is deposited in many organs in the form of the insoluble tribasic lead phosphates. A significant part of the lead is deposited in the trabeculae of the bones. Under the influence of provoking factors, an intensive lead release from the depot can be observed. In such cases, the amount of lead in the circulating blood increases sharply, and remission is replaced by an exacerbation. There is a wavy course of chronic lead intoxication. Lead and its inorganic compounds belong to the group of poisons that have a polytropic effect on the body, affecting many organs and systems. The blood system (anemia with specific characteristics) and the nervous system (polyneuropathy and encephalopathy) are primarily affected. A number of other organs and systems are also affected. The most severe specific syndrome of gastrointestinal tract damage is lead colic. Due to the impaired synthesis of porphyrins and heme in certain biological substrates of the body — in the blood, erythrocytes and urine, substances unused in the synthesis of heme are accumulated. They are markers of chronic intoxication caused by lead, in the presence of a relevant clinical picture. The diagnosis is based on data from a professional history, sanitary and hygienic characteristics of working conditions, clinical and objective characteristics of the disease and data from laboratory examination. The main thing is to stop contact with lead and remove it from the body. Antidotes for lead poisoning are chelators: tetacinum-calcium, pentacinum, D-penicillamine. In combination with technical and sanitary-hygienic measures to prevent chronic intoxication caused by lead, preliminary and periodic medical examinations of persons in contact with lead are of great importance.
Comparison of the effects of combined neuraxial anesthesia and multicomponent low-flow inhalation anesthesia in the structure of perioperative anesthesia management in arthroscopic knee surgeries
Authors: Yevsieieva V.V. , Skobenko Ye.O. , Zenkina L.M. , Malimonenko M.O. , Savchenko S.O. 
Published: August 2021

Background. Arthroscopic knee surgery is one of the most common types of surgeries in the world. But the optimal anesthesia management for this type of orthopedic surgery is still debatable. The purpose of the study was to improve the quality of anesthesia management for arthroscopic interventions on the knee joint by introducing a personalized perioperative anesthesia management. Materials and methods. One hundred and forty-two patients aged 18–78 years, who underwent arthroscopic knee surgery, took part in the study. They were randomized into 2 groups according to the type of anesthesia chosen by the patient. In the first group (n1 = 82), individuals underwent neuraxial anesthesia in combination with intravenous administration of dexmedetomidine, in the second group (n2 = 60) — multicomponent low-flow inhalation anesthesia with sevoflurane combined with multimodal analgesia. Before the operation, the level of preoperative stress was assessed. During the first 24 hours after surgery, we have evaluated the level of postoperative pain by the visual analogue scale, the incidence of postoperative nausea and vomiting, and overall patient’s satisfaction with the surgery. Results. The level of pain according to the visual analogue scale, the incidence of postoperative nausea and vomiting, the level of satisfaction in the study groups did not differ significantly. The level of preoperative stress had a significant impact on the patient’s choice regarding the type of anesthesia. Conclusions. Neuraxial and general anesthesia for arthroscopic knee surgery has advantages and disadvantages. Decision-making on the method of anesthesia should be based on the patient’s wishes and possible previous surgical experience.
Respon Agama terhadap Kemiskinan: Perspektif Sosiologi
Authors: Aeni Nurul 
Published: August 2021

This article aims to provide an overview of the phenomenon of poverty from a sociological perspective, especially from the perspective of the sociology of religion. This article uses a literature review, which is a literature review that supports a particular problem that is being studied in depth. The data in this article were obtained from books, journals, articles, theses and other relevant literature. The results of this study indicate that sociological poverty is not only a personal phenomenon but also a social phenomenon. In the context of religion, Islam responds to the phenomenon of poverty by encouraging and encouraging people to work hard and share with each other.
Abstrak
Artikel ini bertujuan untuk memberikan gambaran tentang fenomena kemiskinan dari perspektif sosiologi, utamanya dari perspektif sosiologi agama. Artikel ini menggunakan kajian literatur, yaitu suatu kajian pustaka yang mendukung suatu permasalahan tertentu yang sedang di kaji secara mendalam. Data dalam artikel ini di peroleh dari buku, jurnal, artikel, skripsi dan literatur lainnya yang relevan. Hasil dari kajian ini menunjukkan bahwa kemiskinan secara sosiologis bukan hanya fenomena personal, namun juga fenomena sosial. Dalam konteks Agama, Islam merespons fenomena kemiskinan dengan anjuran dan dorongan agar manusia giat bekerja dan saling berbagi.
Conselho Municipal de Educação de Alambari/SP: qualidade, gestão democrática e participação na concepção dos conselheiros
Authors: Giordano Daniele Xavier Ferreira , Souza Luciane Del Ben de 
Published: August 2021

Este artigo analisa a compreensão dos membros do Conselho Municipal de Educação de Alambari/SP acerca dos referenciais de qualidade, gestão democrática e participação, com a finalidade de verificar quais estratégias e instrumentos são utilizados na efetividade de suas ações junto à comunidade local. Para tanto, buscou-se como orientação metodológica a pesquisa qualitativa por meio de questionário semiestruturado. Dos 9 (nove) membros do referido conselho, apenas 3 (três) demonstraram interesse em participar da aplicação do questionário. As respostas foram analisadas a partir dos referenciais elencados e foi possível compreender que, embora a atual gestão do Conselho Municipal de Educação de Alambari/SP seja atuante e demonstre grande preocupação com o atendimento à demanda educacional local, a gestão democrática ainda é embrionária e os referenciais de qualidade da educação e participação necessitam de mais diálogo.
Optimization of local government activities in the provision of public services
Authors: Lutsiv I.I. 
Published: August 2021

The article is devoted to the study of optimization of local government in the context of public services in con-nection with the implementation of the Law of Ukraine of November 3, 2020 «On Amendments to Certain Leg-islative Acts of Ukraine on Optimizing the Network and Functioning of Administrative Service Centers services provided in electronic form». It is determined that public services provided by local governments are a type of activity of executive bodies of local self-government and municipal institutions and organizations created by them to implement informational, consulting, registration, permitting and other administrative functions performed on a budget basis, in accordance with the established regulations, technological and information cards, ensure the right of individuals and legal entities to meet the needs with minimal time and at the appropriate professional level. It is noted that technological and information cards of public services provided by local governments are a legal act adopted by local governments providing public services, which contains a consistent description of administra-tive procedures necessary for the implementation of all components of the service, as well as the standard of provid-ing such a service, which is drawn up and communicated directly to the applicant by officials of the body providing the service or authorized persons.
It is indicated that for the state, which implements the general administrative policy in one legal field of distribu-tion of powers of local governments, the work on standardization of technological and information cards should be carried out centrally, at the state level. It is necessary to form and approve a single standard list of public services, based on all available powers of local governments.
Strategic communications as a special kind of interaction of the ministry of defense of Ukraine with other state bodies
Authors: Ponomareva D.S. 
Published: August 2021

The purpose of the article is to determine the place of strategic communications in the conceptual apparatus of administrative law as a special type of interaction between executive authorities and other state bodies.The article focuses on the fact that the radical reform of the security and defense sector of Ukraine in accordance with the North Atlantic standards necessitates the development and legalization of new means and methods of pub-lic administration for national practice. These, in particular, include strategic communications, which is a type of interaction between the subjects of public relations.
The article substantiates that strategic communications are inherently a type of information interaction, the sub-jects of which strive to achieve their goals with the help of an arsenal of special means, the most important of which is the strategic narrative. Not all aspects of strategic communications are governed by legal regulations. A complex set of means of information impact can cause consequences that cannot be objectively categorized (in particular, emotional-volitional consequences). At the same time, the organizational and regulatory aspects of strategic com-munications are unambiguously covered by the methodological apparatus of legal science.The article establishes that, in terms of content, strategic communications is a special type of information inter-action between executive authorities and other entities related to the security and defense sector.It has been proved that strategic communications as a special type of interaction between the Ministry of Defense of Ukraine and other state bodies are information interaction regulated by the norms of law and conditioned by the rights and obligations of these entities, aimed at achieving their goals. Legal regulation of the goals of strategic com-munications is carried out at the level of national strategies, doctrines and concepts adopted to ensure the defense capability of our state. In terms of the organization of strategic communications and the legal status of its subjects, relations are indicated refer to the subject of legal science. Psychological, sociological, political, economic, military aspects of strategic communications belong to the subject of study of the relevant sciences.It was determined that the directions of further scientific research should take into account the need for a more complete legalization of strategic communications in legislative acts regulating the legal status of subjects of the security and defense sector.
The european court of human rights practice influence on the national system of Ukraine
Authors: Kalyuzhna E.S. 
Published: August 2021

Ukraine has recognized the jurisdiction of the European Court of Human Rights by acceding to the Convention for the Protection of Human Rights and Fundamental Freedoms. The implementation of Western concepts of the rule of law, human dignity and human rights stipulates study of the European Court of Human Rights practice, which, in accordance with national law, is the source of Ukrainian law. It is emphasized that the enshrinement of the rule of law principle in a number of laws was accompanied by a normative provision on the necessity to understand the content of this principle through the European Court of Human Rights practice.
The purpose of the study is to elucidate the general provisions characterizing the impact of the European Court of Human Rightsice practice on the national system of Ukraine.
It is substantiated that the European Court of Human Rights ensures the relevance of the Convention for the Protection of Human Rights and Fundamental Freedoms provisions, compliance of its rules with modernity, ensuring the general spirit of the Convention for the Protection of Human Rights and Fundamental Freedoms which is designed to uphold and ensure the values of a democratic society.
It is noted that in interpreting the Convention for the Protection of Human Rights and Fundamental Freedoms, the European Court of Human Rights is a kind of subject of legal doctrines making in the field of human rights affecting the legal systems of the states parties to this Convention.
Some decisions of the European Court of Human Rights in cases against Ukraine, which played a significant role in changing the national legal system, are analyzed, in particular,the decisions in the cases Koretsky and Others v. Ukraine, Natalia Mykhaylenko v. Ukraine, and Volokhy v. Ukraine.
The following legal provisions as the separation of law and the law are mentioned, giving priority to law over the law in case of contradiction between them; understanding the content of the rule of law, the importance of legal certainty and reasoning of the decision to restrict human rights, legal equality of people, and giving real access to a fair trial to a person, etc.
It is concluded that when considering the applicants' complaints about Ukraine's non-fulfillment of its obligations in the field of human rights, the European Court of Human Rights forms legal provisions that become an integral part of the domestic legal system, in some cases they (the decisions) are the factor in changing legislation, and influence the legal doctrine transformation.