bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overcoming the rate–distance limit of device-independent quantum key distribution
Authors: Xie Yuan-Mei , Li Bing-Hong , Lu Yu-Shuo , Cao Xiao-Yu , Liu Wen-Bo , Yin Hua-Lei , Chen Zeng-Bing 
Published: February 2021

Device-independent quantum key distribution (DIQKD) exploits the violation of a Bell inequality to extract secure keys even if users’ devices are untrusted. Currently, all DIQKD protocols suffer from the secret key capacity bound, i.e., the secret key rate scales linearly with the transmittance of two users. Here we propose a heralded DIQKD scheme based on entangled coherent states to improve entangling rates whereby long-distance entanglement is created by single-photon-type interference. The secret key rate of our scheme can significantly outperform the traditional two-photon-type Bell-state measurement scheme and, importantly, surpass the above capacity bound. Our protocol therefore is an important step towards a realization of DIQKD and can be a promising candidate scheme for entanglement swapping in the future quantum internet.
Simple SSMF-based two-channel MGDM system operating in the 0.8  µm wavelength region
Authors: Bae Sunghyun , Kim Byung Gon , Kim Minsik , Chung Yun C. 
Published: February 2021

We propose a simple two-channel mode-group-division-multiplexing (MGDM)
system operating in the 0.8 µm region over the standard single-mode
fiber (SSMF). For the cost-effectiveness, we implement its receiver by
using only two photodetectors (PDs) [instead of three PDs required for
the detection of the

L
P

01

,

L
P

11
a

, and

L
P

11
b

modes]. We then detect the signal
carried by the

L
P

01

mode by using a PD and a mode filter.
On the other hand, the other signal carried by the

L
P

11

mode group is detected by using
another PD and a multiple-input single-output equalizer (i.e., by
subtracting the signal carried by the

L
P

01

mode from the multiplexed signal).
For a demonstration, we transmit

2

×

28

G
b

/

s

MGDM on-off keying signal operating
at 852.6 nm over 2.2 km of the SSMF by using the proposed technique.
The results show that we can achieve the bit-error rate of

<

3.8

×

10

−
3

for both the

L
P

01

and

L
P

11

modes.
Polarization-dependent tuning of Bragg reflection enabled through tilted subwavelength grating waveguide Bragg gratings
Authors: Sun Hao , Chen Lawrence R. 
Published: February 2021

We propose and demonstrate experimentally tilted subwavelength grating (SWG) waveguide Bragg gratings (WBGs). By tilting the SWG segments and optimizing the duty cycle, we can achieve polarization-dependent tuning of the spectral response of the SWG WBG, namely, the spectral response of the fundamental transverse electric (TE) mode shifts toward shorter wavelengths, while that for the transverse magnetic (TM) mode remains almost unchanged. In particular, for tilting angles of 5° and 30°, we can obtain a blueshift in the Bragg wavelength of 7 and 35 nm for the TE mode, while the Bragg wavelength for the TM mode remains within 0.5 nm. The proposed tilted SWG WBGs provide a novel method to manage polarization and/or obtain polarization-dependent wavelength selectivity with integrated WBG devices.
Fully automated point-of-care differential diagnosis of acute febrile illness
Authors: Hin Sebastian , Lopez-Jimena Benjamin , Bakheit Mohammed , Klein Vanessa , Stack Seamus , Fall Cheikh , Sall Amadou , Enan Khalid , Mustafa Mohamed , Gillies Liz , Rusu Viorel , Goethel Sven , Paust Nils , Zengerle Roland , Frischmann Sieghard , Weidmann Manfred , Mitsakakis Konstantinos 
Published: February 2021

Background
In this work, a platform was developed and tested to allow to detect a variety of candidate viral, bacterial and parasitic pathogens, for acute fever of unknown origin. The platform is based on a centrifugal microfluidic cartridge, the LabDisk (“FeverDisk” for the specific application), which integrates all necessary reagents for sample-to-answer analysis and is processed by a compact, point-of-care compatible device.

Methodology/Principal findings
A sample volume of 200 μL per FeverDisk was used. In situ extraction with pre-stored reagents was achieved by bind-wash-elute chemistry and magnetic particles. Enzymes for the loop-mediated isothermal amplification (LAMP) were pre-stored in lyopellet form providing stability and independence from the cold chain. The total time to result from sample inlet to read out was 2 h. The proof-of-principle was demonstrated in three small-scale feasibility studies: in Dakar, Senegal and Khartoum, Sudan we tested biobanked samples using 29 and 9 disks, respectively; in Reinfeld, Germany we tested spiked samples and analyzed the limit of detection using three bacteria simultaneously spiked in whole blood using 15 disks. Overall during the three studies, the FeverDisk detected dengue virus (different serotypes), chikungunya virus, Plasmodium falciparum, Salmonella enterica Typhi, Salmonella enterica Paratyphi A and Streptococcus pneumoniae.

Conclusions/Significance
The FeverDisk proved to be universally applicable as it successfully detected all different types of pathogens as single or co-infections, while it also managed to define the serotype of un-serotyped dengue samples. Thirty-eight FeverDisks at the two African sites provided 59 assay results, out of which 51 (86.4%) were confirmed with reference assay results. The results provide a promising outlook for future implementation of the platform in larger prospective clinical studies for defining its clinical sensitivity and specificity. The technology aims to provide multi-target diagnosis of the origins of fever, which will help fight lethal diseases and the incessant rise of antimicrobial resistance.
“Like a doctor, like a brother”: Achieving competence amongst lay health workers delivering community-based rehabilitation for people with schizophrenia in Ethiopia
Authors: Asher Laura , Birhane Rahel , Teferra Solomon , Milkias Barkot , Worku Benyam , Habtamu Alehegn , Kohrt Brandon A. , Hanlon Charlotte 
Published: February 2021

Background
There are gaps in our understanding of how non-specialists, such as lay health workers, can achieve core competencies to deliver psychosocial interventions in low- and middle-income countries.

Methods
We conducted a 12-month mixed-methods study alongside the Rehabilitation Intervention for people with Schizophrenia in Ethiopia (RISE) pilot study. We rated a total of 30 role-plays and 55 clinical encounters of ten community-based rehabilitation (CBR) lay workers using an Ethiopian adaptation of the ENhancing Assessment of Common Therapeutic factors (ENACT) structured observational rating scale. To explore factors influencing competence, six focus group discussions and four in-depth interviews were conducted with 11 CBR workers and two supervisors at three time-points. We conducted a thematic analysis and triangulated the qualitative and quantitative data.

Results
There were improvements in CBR worker competence throughout the training and 12-month pilot study. Therapeutic alliance competencies (e.g., empathy) saw the earliest improvements. Competencies in personal factors (e.g., substance use) and external factors (e.g., assessing social networks) were initially rated lower, but scores improved during the pilot. Problem-solving and giving advice competencies saw the least improvements overall. Multimodal training, including role-plays, field work and group discussions, contributed to early development of competence. Initial stigma towards CBR participants was reduced through contact. Over time CBR workers occupied dual roles of expert and close friend for the people with schizophrenia in the programme. Competence was sustained through peer supervision, which also supported wellbeing. More intensive specialist supervision was needed.

Conclusion
It is possible to equip lay health workers with the core competencies to deliver a psychosocial intervention for people with schizophrenia in a low-income setting. A prolonged period of work experience is needed to develop advanced skills such as problem-solving. A structured intervention with clear protocols, combined with peer supervision to support wellbeing, is recommended for good quality intervention delivery. Repeated ENACT assessments can feasibly and successfully be used to identify areas needing improvement and to guide on-going training and supervision.
Relationship between anthropometric and biochemical changes of metabolic syndrome with retinal nerve fiber layer and macular thickness
Authors: New Sze Hui , Leow Sue Ngein , Vasudevan Suresh Kumar , Idris Idayu Badilla , Tang Seng Fai , Din Norshamsiah Md 
Published: February 2021

Objective
To evaluate the retinal nerve fiber layer (RNFL) and macular thicknesses and identify systemic risk factors for thinning of these layers in patients with metabolic syndrome (MetS).

Methodology
A cross-sectional observational study was performed on patients diagnosed with MetS and compared to normal controls. All patients underwent ophthalmic and anthropometric examination, serological and biochemical blood investigations; and ocular imaging using spectral-domain optical coherence tomography. Patients with ocular pathology were excluded. Unpaired t-test was used to compare mean thickness between the two groups. One-way ANOVA with Bonferroni correction for multiple comparisons was used to compare mean thickness between different tertiles of MetS parameters, and a generalized estimating equation was used to correct for inter-eye correlation and to assess association between mean thickness and covariates.

Results
Two hundred and forty-eight eyes from 124 participants (1:1 ratio of MetS patients to controls) were included. Age ranged between 30 to 50 years old, and mean age was 40 ± 6.6 years. RNFL thickness was lower globally (93.6 ± 9.9 μm vs 99.0 ± 9.3, p<0.001) and in the inferior (124.5 ± 17.5 μm vs 131.0 ± 16.4 μm, p = 0.002), superior (117.2 ± 16.0 μm vs 126.3 ± 14.4 μm, p<0.001) and temporal (65.5 ± 10.2 μm vs 69.5 ± 9.8, p = 0.002) sectors in MetS patients compared to controls. Only the central (237.0 ± 14.0 μm vs 243.6 ± 18.0 μm, p = 0.002) and inferior parafoveal (307.8 ± 20.9 vs 314.6 ± 14.6, p = 0.004) area of the macula was significantly thinner. The inferior RNFL sector had the most difference (mean difference = 9.1 μm). The Generalized Estimating Equation found that, after adjusting for age, diastolic blood pressure, BMI, HDL and obesity; the number of MetS components and elevated triglyceride levels were independent risk factors for reduced thickness in global RNFL (β = -4.4, 95% CI = -7.29 to -1.5, p = 0.003) and inferior parafovea (β = -6.85, 95% CI = -11.58 to -2.13, p = 0.004) thickness respectively.

Conclusion
RNFL thinning was seen more than macula thinning in MetS patients, suggesting RNFL susceptibility to neurodegeneration than the macula. A higher number of metabolic components and elevated triglyceride levels were independent risk factors for retinal thinning in this group of patients.
Nationwide incidence of sarcomas and connective tissue tumors of intermediate malignancy over four years using an expert pathology review network
Authors: de Pinieux Gonzague , Karanian Marie , Le Loarer Francois , Le Guellec Sophie , Chabaud Sylvie , Terrier Philippe , Bouvier Corinne , Batistella Maxime , Neuville Agnès , Robin Yves-Marie , Emile Jean-Francois , Moreau Anne , Larousserie Frederique , Leroux Agnes , Stock Nathalie , Lae Marick , Collin Francoise , Weinbreck Nicolas , Aubert Sebastien , Mishellany Florence , Charon-Barra Celine , Croce Sabrina , Doucet Laurent , Quintin-Rouet Isabelle , Chateau Marie-Christine , Bazille Celine , Valo Isabelle , Chetaille Bruno , Ortonne Nicolas , Brouchet Anne , Rochaix Philippe , Demuret Anne , Ghnassia Jean-Pierre , Mescam Lenaig , Macagno Nicolas , Birtwisle-Peyrottes Isabelle , Delfour Christophe , Angot Emilie , Pommepuy Isabelle , Ranchere Dominique , Chemin-Airiau Claire , Jean-Denis Myriam , Fayet Yohan , Courrèges Jean-Baptiste , Mesli Nouria , Berchoud Juliane , Toulmonde Maud , Italiano Antoine , Le Cesne Axel , Penel Nicolas , Ducimetiere Francoise , Gouin Francois , Coindre Jean-Michel , Blay Jean-Yves ,   on behalf of the NetSarc/RePPS/ResSos and French Sarcoma Group- Groupe d’Etude des Tumeurs Osseuses (GSF-GETO) networks
Published: February 2021

Background
Since 2010, nationwide networks of reference centers for sarcomas (RREPS/NETSARC/RESOS) collected and prospectively reviewed all cases of sarcomas and connective tumors of intermediate malignancy (TIM) in France.

Methods
The nationwide incidence of sarcoma or TIM (2013–2016) was measured using the 2013 WHO classification and confirmed by a second independent review by expert pathologists. Simple clinical characteristics, yearly variations and correlation of incidence with published clinical trials are presented and analyzed.

Results
Over 150 different histological subtypes are reported from the 25172 patients with sarcomas (n = 18712, 74,3%) or TIM (n = 6460, 25.7%), with n = 5838, n = 6153, n = 6654, and n = 6527 yearly cases from 2013 to 2016. Over these 4 years, the yearly incidence of sarcomas and TIM was therefore 70.7 and 24.4 respectively, with a combined incidence of 95.1/106/year, higher than previously reported. GIST, liposarcoma, leiomyosarcomas, undifferentiated sarcomas represented 13%, 13%, 11% and 11% of tumors. Only GIST, as a single entity had a yearly incidence above 10/106/year. There were respectively 30, 64 and 66 different histological subtypes of sarcomas or TIM with an incidence ranging from 10 to 1/106, 1–0.1/106, or < 0.1/106/year respectively. The 2 latter incidence groups represented 21% of the patients with 130 histotypes. Published phase III and phase II clinical trials (p<10−6) are significantly higher with sarcomas subtypes with an incidence above 1/106 per.

Conclusions
This nationwide registry of sarcoma patients, with exhaustive histology review by sarcoma experts, shows that the incidence of sarcoma and TIM is higher than reported, and that tumors with a very low incidence (1<106/year) are less likely to be included in clinical trials.
Association between physical activity and changes in intestinal microbiota composition: A systematic review
Authors: Aya Viviana , Flórez Alberto , Perez Luis , Ramírez Juan David 
Published: February 2021

IntroductionThe intestinal microbiota comprises bacteria, fungi, archaea, protists, helminths and viruses that symbiotically inhabit the digestive system. To date, research has provided limited data on the possible association between an active lifestyle and a healthy composition of human microbiota. This review was aimed to summarize the results of human studies comparing the microbiome of healthy individuals with different physical activity amounts.MethodsWe searched Medline/Ovid, NIH/PubMed, and Academic Search Complete between August–October 2020. Inclusion criteria comprised: (a) cross-sectional studies focused on comparing gut microbiome among subjects with different physical activity levels; (b) studies describing human gut microbiome responses to any type of exercise stimulus; (c) studies containing healthy adult women and men. We excluded studies containing diet modifications, probiotic or prebiotic consumption, as well as studies focused on diabetes, hypertension, cancer, hormonal dysfunction. Methodological quality and risk of bias for each study were assessed using the Risk Of Bias In Non-randomized Studies—of Interventions tool. The results from cross-sectional and longitudinal studies are shown independently.ResultsA total of 17 articles were eligible for inclusion: ten cross-sectional and seven longitudinal studies. Main outcomes vary significantly according to physical activity amounts in longitudinal studies. We identified discrete changes in diversity indexes and relative abundance of certain bacteria in active people.ConclusionAs literature in this field is rapidly growing, it is important that studies incorporate diverse methods to evaluate other aspects related to active lifestyles such as sleep and dietary patterns. Exploration of other groups such as viruses, archaea and parasites may lead to a better understanding of gut microbiota adaptation to physical activity and sports and its potentially beneficial effects on host metabolism and endurance.
Oral health practices and oral hygiene status as indicators of suicidal ideation among adolescents in Southwest Nigeria
Authors: Folayan Morenike Oluwatoyin , Tantawi Maha El , Oginni Olakunle , Oziegbe Elizabeth , Mapayi Boladale , Arowolo Olaniyi , Adeniyi Abiola Adetokunbo , Sam-Agudu Nadia A. 
Published: February 2021

Background
Oral health is a less-recognized correlate of overall and mental wellbeing. This study aimed to assess the relationship between suicidal behavior (ideation and attempt) and oral health practices and status, and to determine the effect of sex on these associations among Nigerian adolescents.

Methods
Household survey data were collected from 10 to 19-year-old adolescents in southwestern Nigeria. Dependent variables were daily tooth brushing, daily consumption of refined carbohydrates between meals, and oral hygiene status (measured by plaque index). The independent variable was lifetime suicidal ideation/attempt, dichotomized into ‘yes’ and ‘never’. ‘Daily tooth brushing’ and ‘daily consumption of refined carbohydrates between meals’ were included in two separate logistic regression models, and ‘oral hygiene status’ was included in a linear regression model. The models were adjusted for sex, age, and socioeconomic status. The linear regression model was also adjusted for frequency of daily tooth-brushing and of consumption of refined carbohydrates between meals. Interactions between sex and suicidal ideation/suicide attempt in association with dependent variables were assessed. Significance was set at 5%.

Results
We recruited 1,472 participants with mean age (standard deviation) of 14.6 (2.6) years. The mean plaque index was 0.84 (0.56), and 66 (4.5%) adolescents reported ever having suicidal ideation/attempt. Suicidal ideation/attempt was associated with significantly lower likelihood of tooth brushing (OR = 0.48, 95% CI: 0.26, 0.91), higher likelihood of consuming refined carbohydrates between meals (OR = 2.30, 95% CI: 1.29, 4.10), and having poor oral hygiene (B = 0.18, 95% CI: 0.05, 0.32). Among males, suicidal ideation/attempt was associated with less likelihood of eating refined carbohydrates between meals (OR = 0.96, 95% CI: 0.35, 2.61). Conversely, it was associated with a significantly higher likelihood of this outcome (OR = 4.85, 95% CI: 2.23, 10.55) among females.

Conclusion
The study findings suggest that poor tooth brushing habits and poor oral hygiene are indicators for risk of suicidal behavior for adolescents in Nigeria, while high sugar consumption may be an additional risk factor for adolescent females. These findings support the role of dental practitioners as members of healthcare teams responsible for screening, identifying and referring patients at risk for suicidal ideation/attempt.
Prevalence of early childhood caries, risk factors and nutritional status among 3-5-year-old preschool children in Kisarawe, Tanzania
Authors: Ndekero Tumaini S. , Carneiro Lorna C. , Masumo Ray M. 
Published: February 2021

Background
Early childhood dental caries (ECC), a serious public health problem lacks information on the association between ECC, risk factors and nutritional status among children in Tanzania. Therefore, this study aimed to determine the prevalence of ECC, risk factors and nutritional status among 3-5-year-old preschool children and to assess its correlation with the form, visible plaque scores in upper anterior teeth, total sugar exposure, anthropometric measures, and socio demographic attributes.

Methods
This cross-sectional study was conducted on 831 children registered in public preschools in Kisarawe District. Assessment of ECC used the WHO (2013) criteria and anthropometric measures used the WHO Child Growth Standards (2006). Structured questionnaires were completed by children’s parents through an interview. Collected information on socio-demographic attributes including oral hygiene and sugar exposure to their children was analyzed.

Results
Only 459 children (55.2%) were recognized as caries-free. Dental caries experience in terms of decayed, missing and filled teeth (dmft) index was 2.51. Children with visible plaque were the majority (56.1%). The dmft score index was negatively and significantly associated with weight-for-age z-score [Coefficient: -0.11 (95% CI: -0.76, -0.11)] and positively significantly associated with visible plaque score index [Coefficient: 0.16 (95% CI: 0.18, 0.52)] and total sugar exposure [Coefficient: 0.19 (95% CI: 0.15, 0.38)] in the adjusted model. The prevalence of underweight was 4.2% [95% CI: (3.0–5.8)] and severe underweight was 0.2% [95% CI: (0.1–0.9)] while prevalence of stunting was 1.6% [95% CI: (0.9–2.7)] and severe stunting was 0.4% [95% CI: (0.1–1.1)].

Conclusion
This study demonstrated a significant negative relationship between ECC and children’s anthropometric measures indicated by weight-for-age, and positive relationship with sugar exposure and poor oral hygiene indicated by visible plaque on upper anterior teeth. Controlling risk factors will reduce the occurrence of ECC thereby catering for a healthy population of well-nourished children.
Effect of therapeutic hypothermia on renal and myocardial function in asphyxiated (near) term neonates: A systematic review and meta-analysis
Authors: van Wincoop Maureen , de Bijl-Marcus Karen , Lilien Marc , van den Hoogen Agnes , Groenendaal Floris 
Published: February 2021

BackgroundTherapeutic hypothermia (TH) is a well-established neuroprotective therapy applied in (near) term asphyxiated infants. However, little is known regarding the effects of TH on renal and/or myocardial function.ObjectivesTo describe the short- and long-term effects of TH on renal and myocardial function in asphyxiated (near) term neonates.MethodsAn electronic search strategy incorporating MeSH terms and keywords was performed in October 2019 and updated in June 2020 using PubMed and Cochrane databases. Inclusion criteria consisted of a RCT or observational cohort design, intervention with TH in a setting of perinatal asphyxia and available long-term results on renal and myocardial function. We performed a meta-analysis and heterogeneity and sensitivity analyses using a random effects model. Subgroup analysis was performed on the method of cooling.ResultsOf the 107 studies identified on renal function, 9 were included. None of the studies investigated the effects of TH on long-term renal function after perinatal asphyxia. The nine included studies described the effect of TH on the incidence of acute kidney injury (AKI) after perinatal asphyxia. Meta-analysis showed a significant difference between the incidence of AKI in neonates treated with TH compared to the control group (RR = 0.81; 95% CI 0.67–0.98; p = 0.03). No studies were found investigating the long-term effects of TH on myocardial function after neonatal asphyxia. Possible short-term beneficial effects were presented in 4 out of 5 identified studies, as observed by significant reductions in cardiac biomarkers and less findings of myocardial dysfunction on ECG and cardiac ultrasound.ConclusionsTH in asphyxiated neonates reduces the incidence of AKI, an important risk factor for chronic kidney damage, and thus is potentially renoprotective. No studies were found on the long-term effects of TH on myocardial function. Short-term outcome studies suggest a cardioprotective effect.