bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transforming River Governance: The Co-Governance Arrangements in the Waikato and Waipaˉ Rivers
Authors: Parsons Meg , Fisher Karen , Crease Roa Petra 
Published: February 2021

AbstractAround the world, many societies are trying to create and apply apparatuses that recognise Indigenous interests in freshwater systems. Such policies and strategies often acknowledge Indigenous peoples’ rights and values they attached to specific waterways, and take the form of new legal agreements which are directed at reconciling diverse worldviews, values, and ways of life within particular environments. In this chapter we review one such arrangement: the co-governance arrangements between the Māori iwi (tribe) Ngāti Maniapoto and the New Zealand (Government) to co-govern and co-manage the Waipā River. We analysis where the new governance arrangements are enabling Ngāti Maniapoto to achieve environmental justice and find substantive faults most notably distributive inequities, lack of participatory parity, and inadequate recognition of Māori governance approaches.
Mathematical properties of nested residues and their application to multi-loop scattering amplitudes
Authors: Aguilera-Verdugo J. Jesús , Hernández-Pinto Roger J. , Rodrigo Germán , Sborlini German F. R. , Torres Bobadilla William J. 
Published: February 2021

Abstract
The computation of multi-loop multi-leg scattering amplitudes plays a key role to improve the precision of theoretical predictions for particle physics at high-energy colliders. In this work, we focus on the mathematical properties of the novel integrand-level representation of Feynman integrals, which is based on the Loop-Tree Duality (LTD). We explore the behaviour of the multi-loop iterated residues and explicitly show, by developing a general compact and elegant proof, that contributions associated to displaced poles are cancelled out. The remaining residues, called nested residues as originally introduced in ref. [1], encode the relevant physical information and are naturally mapped onto physical configurations associated to nondisjoint on-shell states. By going further on the mathematical structure of the nested residues, we prove that unphysical singularities vanish, and show how the final expressions can be written by using only causal denominators. In this way, we provide a mathematical proof for the all-loop formulae presented in ref. [2].
Complex Sachdev-Ye-Kitaev model in the double scaling limit
Authors: Berkooz Micha , Narovlansky Vladimir , Raj Himanshu 
Published: February 2021

Abstract
We solve for the exact energy spectrum, 2-point and 4-point functions of the complex SYK model, in the double scaling limit at all energy scales. This model has a U(1) global symmetry. The analysis shows how to incorporate a chemical potential in the chord diagram picture, and we present results for the various observables also at a given fixed charge sector. In addition to matching to the spectral asymmetry, we consider an analogous asymmetry measure of the 2-point function obeying a non-trivial dependence on the operator’s dimension. We also provide the chord diagram structure for an SYK-like model that has a U(M) global symmetry at any disorder realization. We then show how to exactly compute the effect of inserting very heavy operators, with formally infinite conformal dimension. The latter separate the gravitational spacetime into several parts connected by an interface, whose properties are exactly computable at all scales. In particular, light enough states can still go between the spaces. This behavior has a simple description in the chord diagram picture.
Primordial monopoles and strings, inflation, and gravity waves
Authors: Chakrabortty Joydeep , Lazarides George , Maji Rinku , Shafi Qaisar 
Published: February 2021

Abstract
We consider magnetic monopoles and strings that appear in non-supersymmetric SO(10) and E6 grand unified models paying attention to gauge coupling unification and proton decay in a variety of symmetry breaking schemes. The dimensionless string tension parameter Gμ spans the range 10−6− 10−30, where G is Newton’s constant and μ is the string tension. We show how intermediate scale monopoles with mass ∼ 1013− 1014 GeV and flux ≲ 2.8 × 10−16 cm−2s−1sr−1, and cosmic strings with Gμ ∼ 10−11− 10−10 survive inflation and are present in the universe at an observable level. We estimate the gravity wave spectrum emitted from cosmic strings taking into account inflation driven by a Coleman-Weinberg potential. The tensor-to-scalar ratio r lies between 0.06 and 0.003 depending on the details of the inflationary scenario.
Black hole hair removal for N = 4 CHL models
Authors: Chakrabarti Subhroneel , Govindarajan Suresh , Shanmugapriya P. , Srivastava Yogesh K. , Virmani Amitabh 
Published: February 2021

Abstract
Although BMPV black holes in flat space and in Taub-NUT space have identical near-horizon geometries, they have different indices from the microscopic analysis. For K3 compactification of type IIB theory, Sen et al. in a series of papers identified that the key to resolving this puzzle is the black hole hair modes: smooth, normalisable, bosonic and fermionic degrees of freedom living outside the horizon. In this paper, we extend their study to N = 4 CHL orbifold models. For these models, the puzzle is more challenging due to the presence of the twisted sectors. We identify hair modes in the untwisted as well as twisted sectors. We show that after removing the contributions of the hair modes from the microscopic partition functions, the 4d and 5d horizon partition functions agree. Special care is taken to present details on the smoothness analysis of hair modes for rotating black holes, thereby filling an essential gap in the literature.
The rare hemoglobin variant Hb Mizuho: report of a Swiss family and literature review
Authors: Njue Linet , Medri Cesare , Keller Peter , Diepold Miriam , Taleghani Behrouz Mansouri , Rovó Alicia 
Published: February 2021

AbstractHb Mizuho is a very rare unstable hemoglobin; here, we describe the clinical history of three Swiss family members with Hb Mizuho together with a systematic review of the previously six published cases. The clinical history of the adult woman we report here is unique since this is the first Hb Mizuho presenting with Moyamoya complications and the first case reported with long-term erythrocyte exchange. The literature review showed that Hb Mizuho was mainly reported as a de novo mutation, with the exception of children descended from known cases. All published patients with this unstable hemoglobin showed severe hemolytic anemia with the exception of one; all were regularly transfused. Patients with higher HbF levels might require fewer transfusions. All patients underwent splenectomy at a median age of 4 years and had variable clinical improvement; some achieved complete resolution of transfusion dependency after splenectomy. Iron overload in Hb Mizuho patients seems to be mainly attributed to transfusions and has less to do with ineffective erythropoiesis. Diagnosis might be challenging; a normal hemoglobin electrophoresis should not rule out the diagnosis of unstable hemoglobin in patients with otherwise unexplained hemolytic anemia. This series shows the enormous utility of using molecular techniques for diagnosis.
Impact of the Trifecta bioprosthetic valve in patients with low-flow severe aortic stenosis
Authors: Takaseya Tohru , Oryoji Atsunobu , Takagi Kazuyoshi , Fukuda Tomofumi , Arinaga Koichi , Hiromatsu Shinichi , Tayama Eiki 
Published: February 2021

AbstractAortic stenosis (AS) is the most common valve disorder in advanced age. Previous reports have shown that low-flow status of the left ventricle is an independent predictor of cardiovascular mortality after surgery. The Trifecta bioprosthesis has recently shown favorable hemodynamic performance. This study aimed to evaluate the effect of the Trifecta bioprosthesis, which has a large effective orifice area, in patients with low-flow severe AS who have a poor prognosis. We retrospectively evaluated 94 consecutive patients with severe AS who underwent aortic valve replacement (AVR). Patients were divided into two groups according to the stroke volume index (SVI): low-flow (LF) group (SVI < 35 ml/m2, n = 22) and normal-flow (NF) group (SVI ≥ 35 ml/m2, n = 72). Patients’ characteristics and early and mid-term results were compared between the two groups. There were no differences in patients’ characteristics, except for systolic blood pressure (LF:NF = 120:138 mmHg, p < 0.01) and the rate of atrial fibrillation between the groups. A preoperative echocardiogram showed that the pressure gradient was higher in the NF group than in the LF group, but aortic valve area was similar. The Trifecta bioprosthesis size was similar in both groups. The operative outcomes were not different between the groups. Severe patient–prosthesis mismatch (PPM) (< 0.65 cm2/m2) was not observed in either of the groups. There were no significant differences in mid-term results between the two groups. The favorable hemodynamic performance of the Trifecta bioprosthesis appears to have the similar outcomes in the LF and NF groups. AVR with the Trifecta bioprosthesis should be considered for avoidance of PPM, particularly in AS patients with LV dysfunction.
Efficacy of a low-FODMAP diet in adult irritable bowel syndrome: a systematic review and meta-analysis
Authors: van Lanen Anne-Sophie , de Bree Angelika , Greyling Arno 
Published: February 2021

Abstract
Purpose
This review provides an updated overview of observational and intervention studies investigating the effect of a low-FODMAP (fermentable oligo-, di- and monosaccharides, and polyols) diet (LFD) on gastrointestinal (GI) symptoms, quality of life (QoL), nutritional adequacy, and gut microbiome in irritable bowel syndrome (IBS) patients.

Methods
We systematically searched available literature until October 2020 for studies that investigated the effect of LFDs on GI symptoms, QoL, nutritional adequacy, and the gut microbiome in IBS patients. The data were represented as standardized mean differences (SMD) for IBS severity, and as mean differences (MD) for IBS-QoL. Meta-analyses were performed for the quantitative analyses using random effects models with inverse variance weighing.

Results
Twelve papers (nine parallel trials, three crossover studies) were included for the meta-analysis. The LFD reduced IBS severity by a moderate-to-large extent as compared to a control diet (SMD − 0.66, 95% CI − 0.88, − 0.44, I2 = 54%). When analyzing only studies that used the validated IBS-SSS questionnaire, a mean reduction of 45 points (95% CI − 77, − 14; I2 = 89%) was observed. Subgroup analyses on adherence, age, intervention duration, IBS subtype, outcome measure, and risk of bias revealed no significantly different results. The LFD also increased IBS-QoL scores, when compared with a control diet (MD 4.93; 95% CI 1.77, 8.08; I2 = 42%).

Conclusions
The low-FODMAP diet reduces GI symptoms and improves quality of life in IBS subjects as compared to control diets. Future work is required to obtain definitive answers regarding potential long-term effects of such diets on nutritional adequacy and the gut microbiome.

PROSPERO registration number
CRD42020175157.
Plasma p-tau231: a new biomarker for incipient Alzheimer’s disease pathology
Authors: Ashton Nicholas J. , Pascoal Tharick A. , Karikari Thomas K. , Benedet Andréa L. , Lantero-Rodriguez Juan , Brinkmalm Gunnar , Snellman Anniina , Schöll Michael , Troakes Claire , Hye Abdul , Gauthier Serge , Vanmechelen Eugeen , Zetterberg Henrik , Rosa-Neto Pedro , Blennow Kaj 
Published: February 2021

AbstractThe quantification of phosphorylated tau in biofluids, either cerebrospinal fluid (CSF) or plasma, has shown great promise in detecting Alzheimer’s disease (AD) pathophysiology. Tau phosphorylated at threonine 231 (p-tau231) is one such biomarker in CSF but its usefulness as a blood biomarker is currently unknown. Here, we developed an ultrasensitive Single molecule array (Simoa) for the quantification of plasma p-tau231 which was validated in four independent cohorts (n = 588) in different settings, including the full AD continuum and non-AD neurodegenerative disorders. Plasma p-tau231 was able to identify patients with AD and differentiate them from amyloid-β negative cognitively unimpaired (CU) older adults with high accuracy (AUC = 0.92–0.94). Plasma p-tau231 also distinguished AD patients from patients with non-AD neurodegenerative disorders (AUC = 0.93), as well as from amyloid-β negative MCI patients (AUC = 0.89). In a neuropathology cohort, plasma p-tau231 in samples taken on avergae 4.2 years prior to post-mortem very accurately identified AD neuropathology in comparison to non-AD neurodegenerative disorders (AUC = 0.99), this is despite all patients being given an AD dementia diagnosis during life. Plasma p-tau231 was highly correlated with CSF p-tau231, tau pathology as assessed by [18F]MK-6240 positron emission tomography (PET), and brain amyloidosis by [18F]AZD469 PET. Remarkably, the inflection point of plasma p-tau231, increasing as a function of continuous [18F]AZD469 amyloid-β PET standardized uptake value ratio, was shown to be earlier than standard thresholds of amyloid-β PET positivity and the increase of plasma p-tau181. Furthermore, plasma p-tau231 was significantly increased in amyloid-β PET quartiles 2–4, whereas CSF p-tau217 and plasma p-tau181 increased only at quartiles 3–4 and 4, respectively. Finally, plasma p-tau231 differentiated individuals across the entire Braak stage spectrum, including Braak staging from Braak 0 through Braak I–II, which was not observed for plasma p-tau181. To conclude, this novel plasma p-tau231 assay identifies the clinical stages of AD and neuropathology equally well as plasma p-tau181, but increases earlier, already with subtle amyloid-β deposition, prior to the threshold for amyloid-β PET positivity has been attained, and also in response to early brain tau deposition. Thus, plasma p-tau231 is a promising novel biomarker of emerging AD pathology with the potential to facilitate clinical trials to identify vulnerable populations below PET threshold of amyloid-β positivity or apparent entorhinal tau deposition.
Comparison of evolving gradient damage formulations with different activity functions
Authors: Wosatko Adam 
Published: February 2021

AbstractIn the paper, two existing upgrades of the gradient damage model for the simulations of cracking in concrete are compared. The damage theory is made nonlocal via a gradient enhancement to overcome the mesh dependence of simulation results. The implicit gradient model with an averaging equation, where the internal length parameter is assumed as constant during the strain softening analysis, gives unrealistically broadened damage zones. The gradient enhancement of the scalar damage model can be improved via a function of an internal length scale, so an evolution of the gradient activity is postulated during the localization process. Two different modifications of the averaging equation and respective evolving gradient damage formulations are presented. Different activity functions are tested to see whether the formation of a too wide damage zone still occurs. Activating or localizing character of the gradient influence can be introduced and the impact of both approaches on the numerical results is shown in the paper. The aforementioned variants are implemented and examined using the benchmarks of tension in a bar and bending of a cantilever beam.
Material parameter identification of unidirectional fiber-reinforced composites
Authors: Hartmann Stefan , Gilbert Rose Rogin , Marghzar Ali Kheiri , Leistner Chris , Dileep Pranav Kumar 
Published: February 2021

AbstractIn this article, several aspects of material parameter identification are addressed. We compare several methods to identify material parameters of a constitutive model for small strain, linear elastic transverse isotropy based on experimental data of specimens made from composite plates. These approaches range from identifying the five material parameters from purely analytical considerations to the fully numerical identification on the basis of finite elements and various data provided by digital image correlation (DIC). The underlying experimental tests range from purely uniaxial tensile tests with varying fiber orientation to shear and compression tests. A specific measuring instrument has been developed for the latter tests to obtain unique material parameters—motivated by the concept of local identifiability. Besides, we compare the numerical differentiation, which is the common procedure in parameter identification, with the fully analytical derivation of sensitivities within the DIC/FEM approach.
A geometry- and muscle-based control architecture for synthesising biological movement
Authors: Walter Johannes R. , Günther Michael , Haeufle Daniel F. B. , Schmitt Syn 
Published: February 2021

AbstractA key problem for biological motor control is to establish a link between an idea of a movement and the generation of a set of muscle-stimulating signals that lead to the movement execution. The number of signals to generate is thereby larger than the body’s mechanical degrees of freedom in which the idea of the movement may be easily expressed, as the movement is actually executed in this space. A mathematical formulation that provides a solving link is presented in this paper in the form of a layered, hierarchical control architecture. It is meant to synthesise a wide range of complex three-dimensional muscle-driven movements. The control architecture consists of a ‘conceptional layer’, where the movement is planned, a ‘structural layer’, where the muscles are stimulated, and between both an additional ‘transformational layer’, where the muscle-joint redundancy is resolved. We demonstrate the operativeness by simulating human stance and squatting in a three-dimensional digital human model (DHM). The DHM considers 20 angular DoFs and 36 Hill-type muscle–tendon units (MTUs) and is exposed to gravity, while its feet contact the ground via reversible stick–slip interactions. The control architecture continuously stimulates all MTUs (‘structural layer’) based on a high-level, torque-based task formulation within its ‘conceptional layer’. Desired states of joint angles (postural plan) are fed to two mid-level joint controllers in the ‘transformational layer’. The ‘transformational layer’ communicates with the biophysical structures in the ‘structural layer’ by providing direct MTU stimulation contributions and further input signals for low-level MTU controllers. Thereby, the redundancy of the MTU stimulations with respect to the joint angles is resolved, i.e. a link between plan and execution is established, by exploiting some properties of the biophysical structures modelled. The resulting joint torques generated by the MTUs via their moment arms are fed back to the conceptional layer, closing the high-level control loop. Within our mathematical formulations of the Jacobian matrix-based layer transformations, we identify the crucial information for the redundancy solution to be the muscle moment arms, the stiffness relations of muscle and tendon tissue within the muscle model, and the length–stimulation relation of the muscle activation dynamics. The present control architecture allows the straightforward feeding of conceptional movement task formulations to MTUs. With this approach, the problem of movement planning is eased, as solely the mechanical system has to be considered in the conceptional plan.
A mouth rinse based on a tea solution of Salvia officinalis for oral discomfort in palliative cancer care: a randomized controlled trial
Authors: Monsen Ragnhild Elisabeth , Herlofson Bente Brokstad , Gay Caryl , Fjeld Katrine Gahre , Hove Lene Hystad , Malterud Karl Egil , Saghaug Elisabeth , Slaaen Joran , Sundal Tone , Tollisen Anita , Lerdal Anners 
Published: February 2021

Abstract
Background
Few clinical studies evaluate interventions to reduce oral discomfort among patients in palliative care.

Aim
This study examines the efficacy of a Salvia officinalis (SO) based herbal mouth rinse compared to conventional normal saline (NS) in order to improve oral health.

Design
A block-randomized controlled trial. Data were collected before and after a 4-day intervention with either SO (n=44) or NS (n=44). Numerical rating scales (NRS, 0–10) and 12 items from the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Oral Health 17 (EORTC QLQ-OH17) measured patient-reported oral symptoms. An oral examination was performed before and after the intervention.

Setting/participants
This study included adult patients with late-stage cancer in an inpatient hospice unit.

Results
Of the 88 patients included (mean age=63.9 years, SD=10.6), 73 (83%) completed the study. At baseline, 78% reported dry mouth on the EORTC QLQ-OH17, and 80% rated dry mouth ≥4 on the NRS. Total oral health scores based on the 12 EORTC QLQ-OH17 items improved similarly in both groups (p<0.001). However, dry mouth ratings on both the EORTC QLQ-OH17 (p=0.036) and NRS (p=0.045) improved more in the SO group than in the NS group. Plaque on the teeth improved in both the SO (p=0.008) and NS (p=0.018) groups, but plaque on the tongue and erythema only improved with NS.

Conclusions
This study did not detect an overall significant difference between SO and NS. Both mouth rinses improved oral health parameters, indicating that systematic assessment and oral care may reduce oral discomfort.

Trial registration
NCT02067572
Climatic trends variability and concerning flow regime of Upper Indus Basin, Jehlum, and Kabul river basins Pakistan
Authors: Latif Yasir , Ma Yaoming , Ma Weiqiang 
Published: February 2021

AbstractThe Indus Basin is referred to as a “water tower” which ensures water storage and supply to sustain environmental and human needs downstream by a balanced combination of precipitation, snow, glaciers, and surface water. The Upper Indus Basin (UIB) combines the high mountain ranges of the Hindukush, Karakoram, and Himalaya (HKH); this unique region is largely controlled by seasonal meltwater associated with snow and glacier melt during the summer months. The present study seeks to evaluate changes in hydrological and meteorological variable data collected through a network of 35 hydrometric and 15 climatic stations, respectively, across the UIB, Jehlum, and Kabul river basins in Pakistan. The Innovative Trend Significance Test (ITST) in combination with the Modified-Mann-Kendall (MMK) test was used for seeking trends, while Sen’s method was applied for the slope determination of detected trends over four periods of differing lengths (T1: 1961–2013; T2: 1971–2013; T3: 1981–2013; and T4: 1991–2013). Significant decreases were observed in the mean summer and distinct months of (June–August) temperature (Tmean) at most of the stations during T1, while significant increases were dominant over the shorter T4. The mean precipitation (Pmean) was observed as significantly negative at ten stations during July; however, positive trends were observed in August and September. For streamflow, significantly upward trends were observed for mean summer, June and July flows (snowmelt dominant) during T1 and T2, within the glacier-fed basins of Hunza, Shigar, and Shyok; in contrast, streamflow (glacier melt dominant) decreased significantly in August and September over the most recent period T4. For snow-fed basins, significant increases were observed in summer mean flows at Indus at Kachura, Gilgit at Gilgit, and Alam Bridge, Astore at Doyian during (T1–T3). In particular, a stronger and more prominent signal of decreasing flows was evident in T4 within the predominantly snow-fed basins. This signal was most apparent in summer mean flows, with a large number of stations featuring significant downward trends in Jehlum and Kabul river basins. The present study concludes that the vulnerability of this region related to water stress is becoming more intense due to significantly increased temperature, reduced precipitation, and decreasing summer flows during T4.