bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decreased Long‐Term Severe Acute Respiratory Syndrome Coronavirus 2–Specific Humoral Immunity in Liver Transplantation Recipients 12 Months After Coronavirus Disease 2019
Authors: Caballero‐Marcos Aránzazu , Citores María Jesús , Alonso‐Fernández Roberto , Rodríguez‐Perálvarez Manuel , Valerio Maricela , Graus Morales Javier , Cuervas‐Mons Valentín , Cachero Alba , Loinaz‐Segurola Carmelo , Iñarrairaegui Mercedes , Castells Lluís , Pascual Sonia , Vinaixa‐Aunés Carmen , González‐Grande Rocío , Otero Alejandra , Tomé Santiago , Tejedor‐Tejada Javier , Fernández‐Yunquera Ainhoa , González‐Diéguez Luisa , Nogueras‐Lopez Flor , Blanco‐Fernández Gerardo , Díaz‐Fontenla Fernando , Bustamante Francisco Javier , Romero‐Cristóbal Mario , Martin‐Mateos Rosa , Arias‐Milla Ana , Calatayud Laura , Marcacuzco‐Quinto Alberto A. , Fernández‐Alonso Víctor , Gómez‐Gavara Concepción , Muñoz Patricia , Bañares Rafael , Pons José Antonio , Salcedo Magdalena 
Published: December 2021

Long‐term humoral immunity and its protective role in liver transplantation (LT) patients have not been elucidated. We performed a prospective multicenter study to assess the persistence of immunoglobulin G (IgG) antibodies in LT recipients 12 months after coronavirus disease 2019 (COVID‐19). A total of 65 LT recipients were matched with 65 nontransplanted patients by a propensity score including variables with recognized impact on COVID‐19. LT recipients showed a lower prevalence of anti‐nucleocapsid (27.7% versus 49.2%; P = 0.02) and anti‐spike IgG antibodies (88.2% versus 100.0%; P = 0.02) at 12 months. Lower index values of anti‐nucleocapsid IgG antibodies were also observed in transplantation patients 1 year after COVID‐19 (median, 0.49 [interquartile range, 0.15‐1.40] versus 1.36 [interquartile range, 0.53‐2.91]; P < 0.001). Vaccinated LT recipients showed higher antibody levels compared with unvaccinated patients (P < 0.001); antibody levels reached after vaccination were comparable to those observed in nontransplanted individuals (P = 0.70). In LT patients, a longer interval since transplantation (odds ratio, 1.10; 95% confidence interval, 1.01‐1.20) was independently associated with persistence of anti‐nucleocapsid IgG antibodies 1 year after infection. In conclusion, compared with nontransplanted patients, LT recipients show a lower long‐term persistence of anti–severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) antibodies. However, SARS‐CoV‐2 vaccination after COVID‐19 in LT patients achieves a significant increase in antibody levels, comparable to that of nontransplanted patients.
Preparation of Zinc Ferrite by Solid State Method and Its Characterizations
Authors: Jadhav Swapnagandha S. , Salunke Vikramsinh Y. , Jadhav Chandrakant H. , Mujawar Sarafraj H. , Bhongale Sanjay R. 
Published: December 2021

AbstractThe zinc ferrite nanoparticles are synthesized by a simple and low cost solid state technique. The synthesized powder is pre‐sintered at 200°C for 5 h and annealing at different temperatures. The crystal structure, phase purity, optical, and morphological analysis studies of synthesized ferrites materiel are investigated by X‐ray diffraction (XRD), scanning electron microscopic (SEM), UV–Visible spectroscopy, and Fourier transform infrared (FTIR) spectroscopic techniques, respectively. The XRD pattern of all zinc ferrite samples shows the formation of single‐phase cubic spinel structure. The optical band gap of zinc ferrite is found to be 1.96 eV. The change in morphology of zinc ferrite is observed due to the effect of the annealing temperature.
Biallelic Loss‐of‐Function NDUFA12 Variants Cause a Wide Phenotypic Spectrum from Leigh/Leigh‐Like Syndrome to Isolated Optic Atrophy
Authors: Magrinelli Francesca , Cali Elisa , Braga Vinícius Lopes , Yis Uluç , Tomoum Hoda , Shamseldin Hanan , Raiman Julian , Kernstock Christoph , Rezende Filho Flávio Moura , Barsottini Orlando Graziani Povoas , Taylor Robert W. , Østergaard Elsebet , Tamim Abdullah , Schäferhoff Karin , Sallum Juliana Maria Ferraz , Zaki Maha S. , Kok Fernando , Bhatia Kailash P. , Wissinger Bernd , Sergeant Kate , Haack Tobias B. , Horvath Rita , Hiz Semra , Alkuraya Fowzan S. , Houlden Henry , Pedroso José Luiz , Maroofian Reza 
Published: December 2021

AbstractBackgroundBiallelic loss‐of‐function NDUFA12 variants have hitherto been linked to mitochondrial complex I deficiency presenting with heterogeneous clinical and radiological features in nine cases only.ObjectivesTo fully characterize, both phenotypically and genotypically, NDUFA12‐related mitochondrial disease.MethodsWe collected data from cases identified by screening genetic databases of several laboratories worldwide and systematically reviewed the literature.ResultsNine unreported NDUFA12 cases from six pedigrees were identified, with presentation ranging from movement disorder phenotypes (dystonia and/or spasticity) to isolated optic atrophy. MRI showed basal ganglia abnormalities (n = 6), optic atrophy (n = 2), or was unremarkable (n = 1). All carried homozygous truncating NDUFA12 variants, three of which are novel.ConclusionsOur case series expands phenotype–genotype correlations in NDUFA12‐associated mitochondrial disease, providing evidence of intra‐ and inter‐familial clinical heterogeneity for the same variant. It confirms NDUFA12 variants should be included in the diagnostic workup of Leigh/Leigh‐like syndromes – particularly with dystonia – as well as isolated optic atrophy.
The strip method for shape derivatives
Authors: Hardesty Sean , Antil Harbir , Kouri Drew P. , Ridzal Denis 
Published: December 2021

AbstractA major challenge in shape optimization is the coupling of finite element method (FEM) codes in a way that facilitates efficient computation of shape derivatives. This is particularly difficult with multiphysics problems involving legacy codes, where the costs of implementing and maintaining shape derivative capabilities are prohibitive. The volume and boundary methods are two approaches to computing shape derivatives. Each has a major drawback: the boundary method is less accurate, while the volume method is more invasive to the FEM code. We introduce the strip method, which computes shape derivatives on a strip adjacent to the boundary. The strip method makes code coupling simple. Like the boundary method, it queries the state and adjoint solutions at quadrature nodes, but requires no knowledge of the FEM code implementations. At the same time, it exhibits the higher accuracy of the volume method. As an added benefit, its computational complexity is comparable to that of the boundary method, that is, it is faster than the volume method. We illustrate the benefits of the strip method with numerical examples.
Assessing adverse event reports of hysteroscopic sterilization device removal using natural language processing
Authors: Mao Jialin , Sedrakyan Art , Sun Tianyi , Guiahi Maryam , Chudnoff Scott , Kinard Madris , Johnson Stephen B. 
Published: December 2021

AbstractObjectiveTo develop an annotation model to apply natural language processing (NLP) to device adverse event reports and implement the model to evaluate the most frequently experienced events among women reporting a sterilization device removal.MethodsWe included adverse event reports from the Manufacturer and User Facility Device Experience database from January 2005 to June 2018 related to device removal following hysteroscopic sterilization. We used an iterative process to develop an annotation model that extracts six categories of desired information and applied the annotation model to train an NLP algorithm. We assessed the model performance using positive predictive value (PPV, also known as precision), sensitivity (also known as recall), and F1 score (a combined measure of PPV and sensitivity). Using extracted variables, we summarized the reporting source, the presence of prespecified and other patient and device events, additional sterilizations and other procedures performed, and time from implantation to removal.ResultsThe overall F1 score was 91.5% for labeled items and 93.9% for distinct events after excluding duplicates. A total of 16 535 reports of device removal were analyzed. The most frequently reported patient and device events were abdominal/pelvic/genital pain (N = 13 166, 79.6%) and device dislocation/migration (N = 3180, 19.2%), respectively. Of those reporting an additional sterilization procedure, the majority had a hysterectomy or salpingectomy (N = 7932). One‐fifth of the cases that had device removal timing specified reported a removal after 7 years following implantation (N = 2444/11 293).ConclusionsWe present a roadmap to develop an annotation model for NLP to analyze device adverse event reports. The extracted information is informative and complements findings from previous research using administrative data.
Switchable gas permeability of a polypropylene‐liquid crystalline composite film
Authors: Houben Simon J. A. , Kloos Joey , Borneman Zandrie , Schenning Albert P. H. J. 
Published: December 2021

AbstractThe development of functionalized polyolefins for use as stimuli‐responsive commodity polymers has recently received much attention. In this work, a microporous polypropylene (PP) scaffold is used to align and fortify a smectic liquid crystalline network (LCN) which can switch its gas permeability upon pH changes. The LCN is a photopolymerized liquid crystalline mixture of a dimerized benzoic acid derivative monoacrylate and a diacrylate crosslinker. In the hydrogen‐bonded state, the composite membrane shows a high‐molecular order and a low permeability for He, N2, and CO2 gases. By pH switching from the hydrogen‐bonded state to the salt form, the molecular order is reduced, and the gas permeability is increased by one order of magnitude. This increase is mainly attributed to a loss in order of the system, increasing the free volume, resulting in an increased diffusibility. By exposing the composite film to basic or acidic environments, reversible switching between low and high gas permeability states is observed, respectively. The physical constraints imposed by the PP scaffold strengthens the membrane while the reversible switching inside the liquid crystalline polymer is maintained. This switching of gas permeation properties is not possible with the fragile freestanding LCN films alone.
An open‐label, dose‐escalation study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of GSK2586881 in participants with pulmonary arterial hypertension
Authors: Simon Marc A. , Hanrott Kate , Budd David C. , Torres Fernando , Grünig Ekkehard , Escribano‐Subias Pilar , Meseguer Manuel L. , Halank Michael , Opitz Christian , Hall David A. , Hewens Deborah , Powley William M. , Siederer Sarah , Bayliffe Andrew , Lazaar Aili L. , Cahn Anthony , Rosenkranz Stephan 
Published: December 2021

AbstractPreclinical and early clinical studies suggest that angiotensin‐converting enzyme type 2 activity may be impaired in patients with pulmonary arterial hypertension (PAH); therefore, administration of exogenous angiotensin‐converting enzyme type 2 (ACE2) may be beneficial. This Phase IIa, multi‐center, open‐label, exploratory, single‐dose, dose‐escalation study (NCT03177603) assessed the potential vasodilatory effects of single doses of GSK2586881 (a recombinant human ACE2) on acute cardiopulmonary hemodynamics in hemodynamically stable adults with documented PAH who were receiving background PAH therapy. Successive cohorts of participants were administered a single intravenous dose of GSK2586881 of 0.1, 0.2, 0.4, or 0.8 mg/kg. Dose escalation occurred after four or more participants per cohort were dosed and a review of safety, tolerability, pharmacokinetics, and hemodynamic data up to 24 h postdose was undertaken. The primary endpoint was a change in cardiopulmonary hemodynamics (pulmonary vascular resistance, cardiac index, and mean pulmonary artery pressure) from baseline. Secondary/exploratory objectives included safety and tolerability, effect on renin‐angiotensin system peptides, and pharmacokinetics. GSK2586881 demonstrated no consistent or sustained effect on acute cardiopulmonary hemodynamics in participants with PAH receiving background PAH therapy (N = 23). All doses of GSK2586881 were well tolerated. GSK2586881 was quantifiable in plasma for up to 4 h poststart of infusion in all participants and caused a consistent and sustained reduction in angiotensin II and a corresponding increase in angiotensin (1–7) and angiotensin (1–5). While there does not appear to be a consistent acute vasodilatory response to single doses of GSK2586881 in participants with PAH, the potential benefits in terms of chronic vascular remodeling remain to be determined.
Optical Control of Bulk Phonon Modes in Crystalline Solids
Authors: Gao Yuan‐Fei , Lai Jia‐Min , Zhang Jun 
Published: December 2021

AbstractLong‐lived phonons within crystalline bulk acoustic wave (BAW) resonators have become coherent carriers of information, which can be utilized for a variety of scientific and technological applications. Herein, a brief introduction to the field of phonon control is given with an emphasis on bulk phonons at high frequencies within crystalline solids. In cavity optomechanics, the photons and phonons can be confined by material boundaries, yielding large optomechanical coupling rates at gigahertz (GHz) frequencies, but the spurious heating is detrimental to robust operation. Although electromechanical techniques can be used to access long‐lived phonons in piezoelectric crystals, they are not suitable for the study of non‐piezoelectric crystals. The phase‐matched Brillouin interactions enable efficient optical access GHz frequency mechanical modes within macroscopic crystalline solids. Combining with the well‐established framework of cavity optomechanics, efficient optical control of BAWs can be obtained. For optical phonons, strong spontaneous Raman cooling and heating based on the interaction between excitons and phonons are considered. In addition, the application of optical phonons in quantum memory at room temperature is introduced. The review finishes with a discussion of the research direction for bulk optomechanical systems and exciton–phonon coupling systems in the future.
Interface Engineering on Cellulose‐Based Flexible Electrode Enables High Mass Loading Wearable Supercapacitor with Ultrahigh Capacitance and Energy Density
Authors: Chen Ruwei , Ling Hao , Huang Quanbo , Yang Yang , Wang Xiaohui 
Published: December 2021

AbstractFor practical energy storage devices, a bottleneck is to retain decent integrated performances while increasing the mass loading of active materials to the commercial level, which highlights an urgent need for novel electrode structure design strategies. Here, an active nitrogen‐doped carbon interface with “high conductivity, high porosity, and high electrolyte affinity” on a flexible cellulose electrode surface is engineered to accommodate 1D active materials. The high conductivity of interface favors fast electron transport, while its high porosity and high electrolyte affinity properties benefit ion migration. As a result, the flexible anode accommodated by carbon nanotubes achieves an ultrahigh capacitance of 9501 mF cm−2 (315.6 F g−1) at a high mass loading of 30.1 mg cm−2, and the flexible cathode accommodated by polypyrrole nanotubes realizes a remarkably high capacitance of 6212 mF cm−2 (248 F g−1, 25 mg cm−2). The assembled flexible quasi‐solid‐state asymmetric supercapacitor delivers a maximum energy density of 1.42 mWh cm−2 (2.2 V, 2105 mF cm−2), representing the highest value among all reported flexible supercapacitors. This versatile design concept provides a new way to prepare high performance flexible energy storage devices.
A Comparative Study of Cobalt Chalcogenides as the Electrode Materials on Lithium‐Sulfur Battery Performance
Authors: Wang Xuejie , Zhu Bicheng , Liu Tao , Zhang Liuyang , Yu Jiaguo 
Published: December 2021

AbstractLithium‐sulfur batteries, as viable options for energy storage, have gained popularity because of their high energy density. However, the poor conductivity of sulfur and Li2S, as well as the shuttling effect of lithium polysulfides, seriously limits their commercialization. Herein, cobalt chalcogenides (Co3O4, CoS, and Co3Se4) supported by reduced graphene oxide are synthesized as the electrode materials, which feature high conductivity, rapid kinetic conversion, and catalytic effect. Based on complementary experimental outputs and advanced computation, it is revealed that the change in anion results in distinctive performance. Among them, the cathode material based on Co3Se4/reduced graphene oxide is the best. The reasons can be ascribed to the conductive and catalytic improvement. This comparative study provides guidelines in the design of lithium‐sulfur batteries via the meticulous regulation of the anions.
OpenNym: Privacy preserving recommending via pseudonymous group authentication
Authors: Checco Alessandro , Bracciale Lorenzo , Leith Douglas J. , Bianchi Giuseppe 
Published: December 2021

AbstractA user accessing an online recommender system typically has two choices: either agree to be uniquely identified and in return receive a personalized and rich experience, or try to use the service anonymously but receive a degraded non‐personalized service. In this paper, we offer a third option to this “all or nothing” paradigm, namely use a web service with a public group identity, that we refer to as an OpenNym identity, which provides users with a degree of anonymity while still allowing useful personalization of the web service. Our approach can be implemented as a browser shim that is backward compatible with existing services and as an example, we demonstrate operation with the Movielens online service. We exploit the fact that users can often be clustered into groups having similar preferences and in this way, increased privacy need not come at the cost of degraded service. Indeed use of the OpenNym approach with Movielens improves personalization performance.
Unravelling consensus genomic regions conferring leaf rust resistance in wheat via meta‐QTL analysis
Authors: Amo Aduragbemi , Soriano Jose Miguel 
Published: December 2021

AbstractLeaf rust, caused by the fungus Puccinia triticina Erikss (Pt), is a destructive disease affecting wheat (Triticum aestivum L.) and a threat to food security. Developing resistant cultivars represents a useful method of disease control, and thus, understanding the genetic basis for leaf rust resistance is required. To this end, a comprehensive bibliographic search for leaf rust resistance quantitative trait loci (QTL) was performed, and 393 QTL were collected from 50 QTL mapping studies. Afterward, a consensus map with a total length of 4,567 cM consisting of different types of markers (simple sequence repeat [SSR], diversity arrays technology [DArT], chip‐based single‐nucleotide polymorphism [SNP] markers, and SNP markers from genotyping‐by‐sequencing) was used for QTL projection, and meta‐QTL (MQTL) analysis was performed on 320 QTL. A total of 75 MQTL were discovered and refined to 15 high‐confidence MQTL (hcmQTL). The candidate genes discovered within the hcmQTL interval were then checked for differential expression using data from three transcriptome studies, resulting in 92 differentially expressed genes (DEGs). The expression of these genes in various leaf tissues during wheat development was explored. This study provides insight into leaf rust resistance in wheat and thereby provides an avenue for developing resistant cultivars by incorporating the most important hcmQTL.
Molecular diagnosis of dermatophyte isolates from canine and feline dermatophytosis in Northeast Iran
Authors: Lavari Atena , Eidi Samaneh , Soltani Minoo 
Published: December 2021

AbstractBackgroundDermatophytes are the most common causes of cutaneous fungal diseases. Dermatophytosis is a common skin disorder in dogs and cats. Species identification of these fungi is important from a therapeutic and epidemiological aspect. Conventional methods used to identify dermatophyte species are often lengthy and may be inefficient in many circumstances. Recently broad varieties of several molecular DNA‐based techniques were successfully utilised for species detection of dermatophytes.ObjectivesThe aim of this study was to determine the molecular detection of dermatophyte isolates from canine and feline dermatophytosis in Mashhad, Iran.MethodsThirty dermatophytes isolated from dogs and cats with skin lesions and one standard strain of Microsporum canis were cultured onto Mycosel agar, and then internal transcribed spacer (ITS) region of the ribosomal DNA was amplified using the universal fungal primers ITS1 and ITS4. PCR products were subjected to sequencing and sequence analysis.ResultsBased on the sequencing of the ITS1‐5.8S‐ITS2 region on all samples, all the studied strains were M. canis and their sexual stage (teleomorph) was Arthroderma otae.ConclusionsMicrosporum canis was the only species found among dogs and cats, and its high prevalence can increase the rate of transmission to humans. In practice, ITS‐PCR, with sequence analysis, is a useful and reliable method to identify and differentiate various pathogenic species, and it can be used in clinical and epidemiological fields, even for the rapid diagnosis of dermatophyte species that are closely interrelated.
Prevalences of mental distress and its associated factors in unaccompanied refugee minors in Germany
Authors: Höhne E. , Banaschewski. T. , Bajbouj M. , Böge K. , Sukale T. , Kamp-Becker I. 
Published: December 2021

AbstractPrevalences for mental disorders within minor refugees are comparatively high and heterogeneous. To reduce heterogeneity and identify high-risk subgroups, we compared unaccompanied refugee minors (URM) to accompanied refugee minors (ARM) regarding depressive symptoms and mental distress. Furthermore, we examined associative factors of mental distress in URM on a broad scale. We conducted a survey with a cross-sectional design in four German University hospitals. The sample consisted of n = 172 URM and n = 52 ARM aged 14–21. Depressive symptoms were assessed via the Patient Health Questionnaire (PHQ-9). Mental distress was assessed by the Refugee Health Screener (RHS-15). Mann–Whitney test was used to examine differences between URM and ARM. Associated factors of mental distress were evaluated via a stepwise multiple regression analysis. URM showed significantly higher mean scores for PHQ-9 (p < .001) and RHS-15 (p < .001) compared to ARM indicating medium effect sizes. Furthermore, URM were significantly more likely to surpass the cut-off for depression (61.6% vs. 30.8%) and overall mental distress (81.4% vs. 53.8%) compared to ARM. The factors Number of stressful life events (SLE), Female gender, and Fear of deportation were found to be associated with an increased mental distress in URM, whereas Weekly contact to a family member, School attendance, and German language skills were accompanied with lower distress scores. All six factors accounted for 32% of the variance of mental distress in URM (p < .001). Within minor refugees, URM are a highly vulnerable subgroup, which should receive particular attention and more targeted measures by health authorities. Our results indicate that these measures should comprise a rapid promotion of family contact, school attendance, language acquisition, and the fast processing of asylum applications. However, the cross-sectional design limits the interpretability of the results.