bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Self‐Capped” Carbon Dots with Excellent Anti‐Bacteria Effect and an Extremely Low Cytotoxicity Applied for Hand Sanitizer
Authors: Wang Meiyan , Peng Nannan , Qin Weixia , Zhu Haimei , Abbas Khurram , Li Yan , Li Zijian , Wang Jingmin , Bi Hong 
Published: February 2025

AbstractThe increasing challenge of antibiotic resistance necessitates the development of novel antibacterial strategies. In this study, a novel kind of self‐capped carbon dots is synthesized from methylene blue (MB) and cetyltrimethylammonium chloride (CTAC), and named as MC‐CDs that are specifically designed for enhanced photodynamic antibacterial activity. Under 660 nm laser irradiation, MC‐CDs demonstrate high inactivation rates of Escherichia coli (96.83%) and Staphylococcus aureus (94.44%) at 14 and 18 µg mL−1 effectively, disrupting bacterial cell membranes. The incorporation of zinc cations (Zn2+) doping further enhances the antibacterial potential of MC‐CDs, enabling substantial efficacy even in the absence of light due to improved electrostatic interactions with bacterial membranes. In comparison to commercial agents such as salicylic acid, p‐chloro‐m‐xylenol, and triclosan, Zn@MC‐CDs exhibit superior antibacterial performance. When formulated into a hand sanitizer, Zn@MC‐CDs maintained over 90% efficacy, displaying excellent stability and extremely low cytotoxicity, highlighting their potential for safe and effective use in personal hygiene products. This study introduces self‐capped carbon dot as a promising antibacterial agent, addressing a critical need for advanced and reliable solutions in infection control.
Interface Engineering of 2D Materials toward High‐Temperature Electronic Devices
Authors: Wang Wenxin , Wu Chenghui , Li Zonglin , Liu Kai 
Published: February 2025

AbstractHigh‐temperature electronic materials and devices are highly sought after for advanced applications in aerospace, high‐speed automobiles, and deep‐well drilling, where active or passive cooling mechanisms are either insufficient or impractical. 2D materials (2DMs) represent promising alternatives to traditional silicon and wide‐bandgap semiconductors (WBG) for nanoscale electronic devices operating under high‐temperature conditions. The development of robust interfaces is essential for ensuring that 2DMs and their devices achieve high performance and maintain stability when subjected to elevated temperatures. This review summarizes recent advancements in the interface engineering of 2DMs for high‐temperature electronic devices. Initially, the limitations of conventional silicon‐based materials and WBG semiconductors, alongside the advantages offered by 2DMs, are examined. Subsequently, strategies for interface engineering to enhance the stability of 2DMs and the performance of their devices are detailed. Furthermore, various interface‐engineered 2D high‐temperature devices, including transistors, optoelectronic devices, sensors, memristors, and neuromorphic devices, are reviewed. Finally, a forward‐looking perspective on future 2D high‐temperature electronics is presented. This review offers valuable insights into emerging 2DMs and their applications in high‐temperature environments from both fundamental and practical perspectives.
Hybrid Electroluminescence Device for On‐Demand Single Photon Generation at Room Temperature
Authors: Rodek Aleksander , Hajdel Mateusz , Oreszczuk Kacper , Kafar Anna , Aktas Muhammed , Marona Łucja , Potemski Marek , Skierbiszewski Czeslaw , Kossacki Piotr 
Published: February 2025

AbstractRecent research focused on single photon emitters (SPEs) hosted by layered semiconductors, particularly hexagonal boron nitride (hBN), has revealed a promising alternative to quantum dots (QDs) for generating single, indistinguishable photons. hBN‐based SPEs offer lower material costs, room temperature emission, and easy integration into potential optoelectronic devices due to the layered structure of the host crystal. This work presents compact hybrid electroluminescence devices, in which GaN laser diodes (LDs) are used for bottom‐to‐top excitation of hBN nanoflakes deposited on the laser facets. This approach circumvents the issue of electroluminescence generation from hBN and provides access to the SPE's signal without optical driving by an external laser. Using laser diodes upgraded with Bragg reflectors a room‐temperature generation of single photons from hBN is confirmed by an 80%‐dip in their g(2) second‐order correlation. The on‐demand emission of single photons at room temperature is demonstrated by driving the laser diodes in pulsed operation, with confidence supported by a measured g(2)(0) value of 0.37.
High‐Performance Zinc‐Lead Alloy Green Quasi‐2D Perovskite Light‐Emitting Diodes
Authors: Zhong Guangchuan , Yuan Guoqiang , Li Boyang , Qiu Langwen , Zhang Yan , Sun Guanwei , Chen Zhao , Meng Fanyuan , Su Shi‐Jian 
Published: February 2025

AbstractLead‐based perovskite light‐emitting diodes (PeLEDs) is gaining significant attention for their outstanding optoelectronic properties. However, the intrinsic lead toxicity in these materials presents serious environmental and health risks, limiting their further development. Here, highly efficient zinc‐lead alloy quasi‐2D perovskites are developed through Zn2+ substitution and additive engineering. The Zn2+ substitution improves tolerance factors, increases radiative recombination rates, and suppresses nonradiative recombination, thereby enhancing stability. Additionally, [bis(4‐methoxyphenyl) phosphinyloxy]carbamic acid tert‐butyl ester (BPCA) additive effectively passivates bromine vacancy defects and improves film quality. The successful Zn2+ substitution and additive passivation strategy results in a significantly increased photoluminescence quantum yield from 4.3 to 85.6%. Consequently, high‐performance zinc‐lead alloy green PeLEDs are achieved with a maximum current efficiency of 54.35 cd A−1 and a peak external quantum efficiency of 22.49%, representing the highest performance among green PeLEDs with partial lead substitution. Moreover, the T50 lifetime of Zn‐Lead alloy PeLEDs is ≈8.9 times longer than that of the pristine PeLEDs. The approach not only mitigates lead toxicity but also improves device efficiency and stability, representing a significant advancement toward safer and more sustainable perovskite‐based optoelectronic devices.
Identification of Three Distinct Subgroups in Antiphospholipid Syndrome: Implication for Sex Differences and Prognostic Outcomes from a Multicenter Study
Authors: Chen Chen , Zhang Ao , Cheng Jianhui , Yao Zhongqiang , Meng Juan , Qin Yilu , Lu Qingyi , Li Yufei , Liu Xiangjun , Li Tianhao , Hou Chao , Tang Yundi , Liu Hongjiang , Xu Ning , Dong Sai , Li Xinxin , Xu Fangmin , Guo Jianping , Li Chun 
Published: February 2025

AbstractAntiphospholipid syndrome (APS) is a heterogeneous autoimmune disease with persistent antiphospholipid antibodies. This study aimed to identify unrecognized APS subgroups from multicenter cohorts (n = 760, training: n = 415; validation: n = 345). Patients are stratified through unsupervised K‐means clustering analysis. Prognostic outcomes are evaluated using Kaplan‐Meier survival analyses. Proteomic analysis is conducted on primary APS patients (n = 36) and healthy controls (n = 12). Key molecule insulin‐like growth factor 1 is validated using ELISA. Three clusters are identified. Cluster 1 (n = 320, 42.1%) is completely consisted of females (100%), with predominant occurrence of pregnancy morbidity (88.8%) but low incidences of thrombocytopenia (18.4%) and thrombosis (15.0%), and a favorable prognosis. Cluster 2 (n = 309, 40.7%) is predominantly female (99.4%) and characterized by high thrombosis (85.8%) and thrombocytopenia (46.6%), low pregnancy morbidity (13.6%), and poor prognosis. Cluster 3 (n = 131, 17.2%) is predominantly male (99.2%), exhibiting highest thrombosis (96.2%) and moderate thrombocytopenia (32.8%), with worst prognosis. Immunological and proteomic analyses clearly differentiated three clusters. This study reveals a distinct difference between obstetric and thrombotic APS, and a sex‐based distinction within thrombotic APS. Three APS subgroups display unique clinical and molecular characteristics, and marked difference in prognostic outcomes.
Multifunctional Conductive Nanofibers for Self‐Powered Glucose Biosensors
Authors: Gungordu Er Seda , Bulathsinghala Rameesh , Kizilates Selvinaz Burcu , Li Bing , Ryan Rucchi , Tabish Tanveer A. , Dharmasena Ishara , Edirisinghe Mohan 
Published: February 2025

AbstractElectrochemical glucose biosensors are essential for diabetes management, and self‐powered systems present an eco‐friendly and innovative alternative. Traditional biosensors face several limitations including limited sensitivity, enzyme instability, and dependency on external power sources. Addressing these issues, the study develops a novel multifunctional nanofiber integrating biosensor for glucose detection and a self‐powered motion sensor, utilizing an innovative triboelectric nanogenerator (TENG) system. Electrospun nanofibers, composed of graphene oxide (GO), porous graphene (PG), graphene foam (GF), polypyrrole (PPy), and polycaprolactone (PCL), demonstrate enhanced electrical conductivity, triboelectric efficiency, and mechanical strength. Among these, dip‐coated nanofibers exhibited the highest conductivity of 4.9 × 10⁻⁵ S/cm, attributed to superior surface electrical properties of GO. PCL/PPy/GO nanofibers achieved the highest glucose detection performance in cyclic voltammetry and differential pulse voltammetry due to efficient electron transfer mechanisms of GO and PPy. Additionally, triboelectric tests revealed peak voltages of 63V with PCL/PPy/GO and polyvinylidene fluoride nanofibers containing glucose oxidase enzyme. Core‐sheath and dip‐coated nanofibers also demonstrated significant mechanical resilience (∼0.9 N force, ∼350 s durability). These findings highlight PCL/PPy/GO nanofibers as a multifunctional, efficient, and scalable solution, offering highly sensitive glucose detection and non‐invasive sweat analysis along with robust energy harvesting for environmentally friendly and advanced diabetes management systems.
Hole‐Mediated Lattice Oxygen Redox Design for Perovskite Oxide Catalysts
Authors: Li Xinbo , Wang Xiyang , Wang Yaowen , Shao Jingze , Wu Yimin A. , Jana Subhajit , Liu Haozhe , Peng Yue , Wu Zhiyao , Li Zhen , Cong Yingge , Zhang Yawen , Li Guangshe , Li Liping 
Published: February 2025

AbstractPresent design and application of perovskite oxide catalysts assume lattice oxygen redox (LOR) mechanisms that depend on lattice oxygen activity without consideration of the entire redox cycle. Herein, using in situ characterizations and theoretical calculations, we uncover a hole‐mediated LOR cycle on p‐type Sr‐deficient SrFeO3–δ (SFO‐Srv) perovskites in CO oxidation reaction. Sr vacancies activate surface lattice oxygen of SFO‐Srv and promote formation of highly covalent Fe(4–x)+‐O(2–x)– sites. In situ electrical conductivity measurement demonstrates that holes directly participate in the entire LOR cycle, and are reversibly consumed and regenerated in reducing/oxidizing atmosphere via Fe(4–x)+‐O(2–x)– sites of SFO‐Srv. Hole‐mediated LOR in SFO‐Srv, as revealed by in situ soft X‐ray absorption spectroscopy, occurs through changing in covalency of Fe−O bonds, O 2p hole state, and electron density of Fe sites. 18O2 labeling experiment further confirms an improved Mars–van Krevelen pathway in the hole‐mediated LOR cycle, which accounts for a ten‐times enhancement of SFO‐Srv for CO reaction rate over that of SFO alone.
Silver Molybdate Nanoparticles for Enhanced Tumor Immunotherapy through Pyroptosis Conversion and Ferroptosis Induction
Authors: Chen Hao , Ding Binbin , Tan Jia , Meng Qi , Li Jing , Zhang Wenying , Zheng Pan , Liu Bin , Ma Ping'an , Lin Jun 
Published: February 2025

AbstractPyroptosis holds great potential in tumor therapy due to its strong immunogenicity. Several strategies, including ion interference therapy (IIT), are developed to induce pyroptosis. However, the mechanism by which metal oxoanions induced pyroptosis remained unclear. It was reported that MoO42− ions could stimulate immune responses, but their pyroptosis‐inducing mechanisms were not fully understood. Herein, we synthesized uniform and dispersed silver molybdate (Ag2MoO4) nanoparticles (AMO) via a solvothermal method. AMO responded to H2O2 and glutathione (GSH) stimuli, releasing Ag+ and MoO42− ions, generating reactive oxygen species (ROS), and depleting GSH, thereby inducing ferroptosis and pyroptosis. The MoO42− also inhibited cell migration and upregulated GSDME expression, converting apoptosis into caspase‐3/GSDME‐mediated pyroptosis. Additionally, DNA damage and ROS activated the cGAS‐STING pathway, enhancing innate immunity. In vivo experiments demonstrated that the combination of AMO and the immune checkpoint inhibitor αPD‐1 significantly inhibited tumor growth. This combination promoted dendritic cells (DCs) maturation, increased effector T cell numbers, induced M1 macrophage polarization, and alleviated immunosuppression. This study contributed to a deeper understanding of metal oxoanion‐mediated pyroptosis, supporting its potential application in cancer immunotherapy.
Cost‐Effective Nanosensor Solutions for Ultra‐Sensitive Detection of Metronidazole
Authors: Mobed Ahmad , Darvishi Mohammad , Alivirdiloo Vahid , Ebrahimi Sara , Hajiabbasi Mobasher , Ghazi Farhood , Khanmiri Hamidreza Hassanzadeh 
Published: February 2025

ABSTRACTMetronidazole (MNZ) is a widely used imidazole antibiotic effective against bacterial and protozoal infections, including giardiasis, trichomoniasis, bacterial vaginosis, and antibiotic‐associated colitis. However, prolonged and excessive use of MNZ can lead to serious side effects, such as peripheral neuropathies, toxicity, and optic neuropathy. Therefore, the accurate detection and removal of MNZ present significant technical challenges. This manuscript introduces novel approaches for the development and integration of precise and cost‐effective sensors specifically designed for the accurate measurement of MNZ levels. We explore cutting‐edge nanotechnology strategies for detecting MNZ, with a particular focus on innovative nanobiosensors, including photodynamic‐based biosensors, acousto dynamic sensors, and electrochemical biosensors. Additionally, we delve into the unique challenges and opportunities associated with multiphysics biometric biosensors and related nanotechnologies in the detection of MNZ. This review not only provides insights and scientific evidence regarding the application of nanobiosensors for the accurate measurement of MNZ but also highlights recent advancements in sensor technology that represent a significant leap forward in this field. By emphasizing these novel contributions, we aim to pave the way for future research and development in this critical area. Ultimately, our findings underscore the importance of reliable detection methods in mitigating the risks associated with MNZ use and improving patient safety.
Catalytic Impact of Nano‐Supramolecular Complex Based on Lead and Quinoline‐2‐Carbxylic Acid Ligand as Efficient Catalyst for Removal of Hazardous Materials From Wastewater
Authors: Dalia Saleh , Mahmoud Samy F. , Etaiw Safaa Eldin H. 
Published: February 2025

ABSTRACTUnder ultrasonication, the nanoscale supramolecular complex [Pb (QCA)2]n (NSC1) was formed by the self‐assembly of lead nitrate and quinoline‐2‐carboxylic acid (QCA) as linking ligand. PbII exhibits a (O2N2) distorted square planner geometry, where the PbII atom coordinates to two QCA ligands, according to single crystal X‐ray diffraction of 1. With a packing structure of 1, facing molecules are arranged in parallel planes and joined by multiple H‐bonds and π‐π stacking to form a three‐dimensional network. NSC1 was examined using a variety of structural characterization techniques as well as spectrum studies. Despite the well‐documented toxicity of lead, which is utilized in various products, the nanoscale supramolecular complex [Pb (QCA)2]n (NSC1) demonstrates considerable safety owing to its stability, remaining unaffected by degradation mediums, as corroborated by different techniques. So, under UV or ultrasonic wave conditions, it has been demonstrated that the heterogeneous catalyst NSC1 exhibits significant catalytic activity in presence of H2O2 against the breakdown of the indicated pollutants, indigo carmine (IC) and phenol (Ph), in very short times. Using the disodium salt of terephthalic acid, the photoluminescence probing method was applied to ascertain the reactive oxygen species and the reaction process mechanism.
Mechanical, Thermal, and Electrical Properties of Epoxy Monolith Sheets Containing Carbon Black
Authors: Kamo Yoshiyuki , Matsumoto Akikazu 
Published: February 2025

ABSTRACTConductive pastes have been used to bond semiconductors and create electrical circuits, but in recent years their use has expanded to include flexible substrates used in portable and wearable electronic devices that require high stretchability. Conductive pastes using metals, carbons, etc. have problems such as the need to add large amounts of filler and the insufficient mechanical strength and poor heat resistance of the binder polymer material. Recently, epoxy monolith as a new material has been developed to achieve high strength and elongation by introducing a porous structure into cured epoxy resin. In this study, we demonstrate that carbon black (CB), which is added as a conductive nanofiller during the manufacturing process of epoxy monoliths, segregates within the framework of the epoxy monolith and forms conductive paths with a three‐dimensional continuous structure. We investigated the structure and mechanical properties of the CB‐containing epoxy monolith sheets and subsequently characterized their electrical and thermal conductivity. Furthermore, we clarified the change in electrical resistance when tensile stress was applied to the monolith sheet.
Internesting Period and Clutch Frequency of the Endangered Loggerhead Turtle Population of Cabo Verde
Authors: Raposo Ana , Rebelo Rui , Marco Adolfo 
Published: February 2025

ABSTRACTKnowledge about the reproductive success of sea turtles is essential for their conservation. These nest preferentially on the beaches where they were born and may nest more than once during each nesting season, with a variable number of nests per female. Several factors can lead to variations in reproductive output. This study estimated the clutch frequency and internesting period of the threatened subpopulation of the loggerhead turtle (Caretta caretta) from the island of Boa Vista, Cabo Verde. This archipelago hosts the second‐largest (or perhaps largest) population of C. caretta globally, with Boa Vista being the most important nesting island. Female distinctions were made on their previous experience (neophytes and remigrants) and their body size. Data were collected between 2013 and 2020 through marking and recapture, on João Barrosa beach, in the Reserva Natural das Tartarugas. In years with more females nesting on beaches, a smaller percentage of nests are studied because of the difficulty in reporting them all. As such, only the first 25% of the nests were analysed. Minimum clutch frequency ranged between 3.8 and 4.1. Remigrants had a larger body size and higher clutch frequency than neophytes, without differences in the internesting period. This study also showed differences between neophyte and remigrant females, specifically only in their measured clutch frequency. However, neophytes likely switch between nesting grounds more often, evading monitoring, and highlighting their potential to move to other islands or to breed out of the main season. These findings enhance our understanding of reproductive strategies, enabling the application of distinct conservation strategies tailored to each group. Satellite telemetry could address study limitations regarding clutch frequency values and provide a better understanding of nesting patterns and the impact of environmental factors on reproduction. This could improve conservation strategies by identifying critical habitats and guiding targeted protective measures, supporting population recovery.
The effect of severe renal impairment on the pharmacokinetics, safety and tolerability of balcinrenone
Authors: Bhattacharya Chandrali S. , Ericsson Hans , Johansson Susanne , Parkinson Joanna , Boca Simina M. , Yang Ye , Heijer Maria , Housler Greggory , Leonsson‐Zachrisson Maria , Hartleib‐Geschwindner Judith , Pizzato Patricia Ely 
Published: February 2025

AimsThe aim of this phase 1 trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone (previously AZD9977) in participants with severe renal impairment vs. those with normal renal function.MethodsParticipants with severe renal impairment (estimated glomerular filtration rate [eGFR] < 30 mL/min/1.73 m2) not on dialysis were compared with group‐matched control participants with eGFR ≥ 90 mL/min/1.73 m2. Eligible participants received a single oral dose of 150 mg balcinrenone, and blood and urine samples were collected for analysis.ResultsThe total apparent balcinrenone clearance was 50% lower in the severe renal impairment group, resulting in an approximately two‐fold higher area under the curve (AUC) and a 1.4‐fold higher maximum observed plasma concentration in the severe renal impairment group compared with the control group. The terminal half‐life and plasma protein binding were similar in both groups. Balcinrenone was safe and well tolerated in all participants. All reported adverse events were of mild‐to‐moderate severity and not considered related to balcinrenone.ConclusionsBalcinrenone exposure was approximately two‐fold higher in participants with severe renal impairment compared with the group‐matched control participants. Based on linear regression analysis of total apparent balcinrenone clearance vs. baseline eGFR, the AUC exposure is predicted to be <50% higher in patients with an eGFR of 20 mL/min/1.73 m2 compared with those with an eGFR of 60 mL/min/1.73 m2. In light of these findings, no dose adjustment based on eGFR is needed in two ongoing studies that target these patients (MIRO‐CKD [NCT06350123] and BalanceD‐HF [NCT06307652]).
Decoding Supply Chain 5.0 Adoption by Grey Influence Analysis: What Barriers and Enablers Lie Within?
Authors: Kumar Sachin , Singh Vinay 
Published: February 2025

ABSTRACTThe adoption of Supply Chain 5.0 in any industry is crucial to the project's success and to minimize the risk of failure. This study explores the potential enablers that mitigate the daunting barriers (a) by prioritizing them and (b) by establishing their causal relationship in modern industries within developing economies. This study was validated using literature analysis and qualitative causal modeling. A semistructured questionnaire was used to interview 16 industry experts to standardize data collection. A twofold analysis was used. Firstly, grey influence analysis prioritized enablers, barriers, and their one‐to‐one influences. These influences were retested in the second fold, and stepwise linear regression confirmed the enablers–barriers causality. The results reveal that green energy is the most influential enabler, followed by universal storage and smart contracts. The most critical barriers include “Acceptance and Adaptability of Robots and Other Machines,” “Security and Privacy,” and “Lack of Green Initiatives.” The regression analysis highlights that “Acceptance and Adaptability of Robots and Other Machines” is the most critical barrier, needing multiple enablers. Universal storage, smart contracts, intelligent systems, and innovative technologies are key enablers for most Supply Chain 5.0 adoption barriers. The study aids in adopting Supply Chain 5.0 by prioritizing key enablers and barriers, guiding decision‐makers in developing economies to mitigate risks and enhance project success within the supply chain context. The study uniquely provides an enablers–barriers causality framework for Supply Chain 5.0, offering actionable insights for successful adoption in developing economies and enhancing academic and practical understanding.