bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Seasonality in the North Atlantic Jet Stream and Storm Migration on the Seasonality of Hurricane Translation Speed Changes
Authors: Guo Xi , Kossin James P. , Tan Zhe-Min 
Published: June 2021

AbstractTropical cyclone (TC) translation speed (TCTS) can affect the duration of TC-related disasters, which is critical to coastal and inland areas. The long-term variation of TCTS and its relationship to the variability of the midlatitude jet stream and storm migration is discussed here for storms near the North Atlantic coast during 1948–2019. Our results reveal the prominent seasonality in the long-term variation of TCTS, which can be largely explained by the seasonality in the covariations of the midlatitude jet stream and storm locations. Specifically, significant increases of TCTS occur in June and October during the past decades, which may result from the equatorward displacement of the jet stream and poleward migration of storm locations. Prominent slowdown of TCTS is found in August, which is related to the weakened jet strength and equatorward storm migration. In September, the effects of poleward displacement and weakening of the jet stream on TCTS are largely compensated by the poleward storm migration, and therefore no significant change in TCTS is observed. Meanwhile, the multidecadal variability of the Atlantic may contribute to the multidecadal variability of TCTS. Our findings emphasize the significance in taking a seasonality view in discussing the variability and trends of near-coast Atlantic TCTS under climate change.
Projected climate impacts of large artificial reservoir impoundment in Yalong River Basin of southwestern China
Authors: Liang Yanan , Cai Yanpeng , Wang Xuan , Li Chunhui , Liu Qiang 
Published: June 2021

AbstractCascade reservoirs were designed for Yalong River Basin, which ranks the 3rd largest hydropower base in China. Reservoir impoundment has certain impacts on local climate, but few researches focus on this field. This paper integrates the spatiotemporal analysis techniques and geostatistical methods to identify the reservoir projected meteorological indices (MIs) variations as well as the impact scope under different circumstances. Results show: The reservoir projected variations of moisture indexes were much more significant than temperatures. Anthropogenic disturbance has led to dramatic decrease of relative humidity in the past decade, far beyond its periodic amplitude range. Moreover, dry valley faced more serious drought risk but reservoir impoundment of this region alleviated the local drought risk. The daily minimum temperature, relative to the maximum temperature, was more sensitive to catchment changes with an earlier appearance of temperature zone variation. Since impounding, the MIs internal relationships in non-dry valley varied significantly more than that in dry valley, with the positive correlation of 0.7 between the relative humidity and precipitation weakened greatly. The severe warming hotspots distributed in the upper reach and had the probability of 0.95- 1 to exceed 1.5℃ IPCC control target. This study provides references for the disturbance of reservoir impoundment to local climate at multiple temporal-spatial scales under different circumstances and contributes to the MIs variation pattern identification and quantitative risk assessment.
Rethinking the Definition of High Risk in Pediatric Salivary Gland Carcinoma
Authors: Acharya Sahaja , Sinard Rebecca N. , Rangel Gustavo , Rastatter Jeffrey C. , Sheyn Anthony 
Published: June 2021

ObjectiveIndications for adjuvant radiation in pediatric salivary gland carcinoma rely on high‐risk criteria extrapolated from adult data. We sought to determine whether adult‐derived high‐risk criteria were prognostic in children aged ≤21 years or young adults aged 22 to 39 years.Study DesignCross‐sectional analysis of a hospital‐based national registry.SettingPatients were identified from the National Cancer Database between 2004 and 2015.MethodsHigh‐risk criteria were defined as adenoid cystic histology, intermediate/high grade, T3/T4, positive margins, and/or lymph node involvement. Exact matching was used to adjust for differences in baseline characteristics between pediatric and young adult patients.ResultsWe identified 215 pediatric patients aged ≤21 years, 317 patients aged 22 to 30 years, and 466 patients aged 31 to 39 years. Within the pediatric cohort, there was no significant difference in overall survival (OS) between low‐ and high‐risk groups (5‐year OS, 100% vs 98.5%; P = .29). In contrast, within the young adult cohorts, there was a significant difference in OS between low‐ and high‐risk groups in patients aged 22 to 30 years (5‐year OS, 100% vs 96.1%; P = .01) and 31 to 39 years (5‐year OS, 100% vs 88.5%; P < .001). When high‐risk patients were matched 1:1 on high‐risk criteria and race, pediatric patients were associated with better OS than those aged 22 to 30 years (P = .044) and those aged 31 to 39 years (P = .005).ConclusionChildren have excellent OS, irrespective of adult‐derived high‐risk status. These findings underscore the need to understand how age modifies clinicopathologic risk factors.
Feeding Tube Placement Following Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma
Authors: Feng Allen L. , Holcomb Andrew J. , Abt Nicholas B. , Mokhtari Tara E. , Suresh Krish , McHugh Christopher I. , Parikh Anuraag S. , Holman Allison , Kammer Rachael E. , Goldsmith Tessa A. , Faden Daniel L. , Deschler Daniel G. , Varvares Mark A. , Lin Derrick T. , Richmon Jeremy D. 
Published: June 2021

ObjectiveTo identify factors that may predict the need for feeding tubes in patients undergoing transoral robotic surgery (TORS) in the perioperative setting.Study DesignRetrospective chart review.SettingAcademic tertiary center.MethodsA retrospective series of patients undergoing TORS for oropharyngeal squamous cell carcinoma (OPSCC) was identified between October 2016 and November 2019 at a single tertiary academic center. Patient data were gathered, such as frailty information, tumor characteristics, and treatment, including need for adjuvant therapy. Multiple logistic regression was performed to identify factors associated with feeding tube placement following TORS.ResultsA total of 138 patients were included in the study. The mean age was 60.2 years (range, 37‐88 years) and 81.9% were male. Overall 82.9% of patients had human papilloma virus–associated tumors, while 28.3% were current or former smokers with a smoking history ≥10 pack‐years. Eleven patients (8.0%) had a nasogastric or gastrostomy tube placed at some point during their treatment. Five patients (3.6%) had feeding tubes placed perioperatively (<4 weeks after TORS), of which 3 were nasogastric tubes. Six patients (4.3%) had feeding tubes placed in the periadjuvant treatment setting for multifactorial reasons; 5 of which were gastrostomy tubes. Only 1 patient (0.7%) was gastrostomy dependent 1 year after surgery. Multiple logistic regression did not demonstrate any significant predictive variables affecting perioperative feeding tube placement following TORS for OPSCC.ConclusionsFeeding tubes are seldom required after TORS for early‐stage OPSCC. With appropriate multidisciplinary planning and care, patients may reliably avoid the need for feeding tube placement following TORS for OPSCC.
A comparison of COVID-19 inpatients by HIV status
Authors: Flannery Sarah , Schwartz Rebecca , Rasul Rehana , Hirschwerk David A , Wallach Frances , Hirsch Bruce , McGowan Joseph 
Published: June 2021

COVID-19 in-hospital morbidity and mortality in people living with HIV (PLWH) were compared to HIV-negative COVID-19 patients within a New York City metropolitan health system, the hardest hit region in the United States early in the pandemic. A total of 10,202 inpatients were diagnosed with COVID-19, of which 99 were PLWH. PLWH were younger (58.3 years (SD = 12.42) versus 64.32 years (SD = 16.77), p < 0.001) and had a higher prevalence of men (73.7% versus 57.9%, p = 0.002) and Blacks (43.4% versus 21.7%, p < 0.001) than the HIV-negative population. PLWH had a higher prevalence of malignancies (18% versus 7%, p = < 0.001), chronic liver disease (12% versus 3%, p < 0.001), and end-stage renal disease (11% versus 4%, p = 0.007). Use of a ventilator, admission to the ICU, and in-hospital mortality were not different. Of the 99 PLWH, 12 were virally unsuppressed and 9 had CD4% < 14. Two of the 12 virally unsuppressed patients and 4/9 patients with CD4% < 14 died. Ninety-one of the 99 PLWH were on treatment for HIV, and 5 of the 8 not on treatment died. Among PLWH with prior values, absolute CD4 count decreased an average of 192 cells/mm3 at the time of COVID-19 diagnosis ( p < 0.001). Hospitalized patients with HIV and COVID-19 coinfection did not have worse outcomes than the general population. Among PLWH, those with CD4%<14 or not on treatment for HIV had higher mortality rates. Those PLWH who received IL-6 inhibitors had lower mortality rates. PLWH given antifungal medications, hydroxychloroquine, antibiotics (including azithromycin), steroids, and vasopressors had higher mortality rates.
Risk Factors for Disability Pension among Young Adults Diagnosed with Attention-deficit Hyperactivity Disorder (ADHD) in Adulthood
Authors: Chen Lingjing , Mittendorfer-Rutz Ellenor , Björkenstam Emma , Rahman Syed , Gustafsson Klas , Taipale Heidi , Tanskanen Antti , Ekselius Lisa , Helgesson Magnus 
Published: June 2021

Objective: To investigate risk factors of disability pension (DP) in young adults diagnosed with ADHD in Sweden. Method: In total, 9718 individuals diagnosed with incident ADHD in young adult age (19–29 years) 2006 to 2011, were identified through national registers. They were followed for 5 years and Cox regression models were applied to analyze the DP risk (overall and by sex), associated with socio-demographics, work-related factors, and comorbid disorders. Results: Twenty-one percent of all received DP. Being younger at diagnosis (hazard ratio [HR] = 1.54; 95%confidence interval [CI] 1.39–1.71); low educational level (HR = 1.97; 95%CI 1.60–2.43 for <10 years); work-related factors at baseline (no income from work [HR = 2.64; 95%CI 2.35–2.98] and sickness absence >90 days [HR = 2.48; 95%CI2.17–2.83]); and schizophrenia/psychoses (HR = 2.16; 95%CI 1.66–2.80), autism (HR = 1.87; 95%CI 1.42–2.46), anxiety (HR = 1.34; 95%CI 1.22–1.49) were significantly associated with an increased risk of DP. Similar risk patterns were found in men and women. Conclusion: Work-related factors and comorbid mental disorders need to be highlighted in early vocational rehabilitation for individuals with ADHD.
Dancing with and within the Digital Domain
Authors: Ravetto-Biagioli Kriss 
Published: June 2021

Digital cameras and motion capture technologies that document and share creative practices have transformed the way we think about dance as an embodied knowledge as well as the way we experience it bodily. Computational media, which not only records and archives but also calculates, analyses and models dance, further complicates its ontological status. This move to document and inscribe dance in a tangible medium marks a shift from understanding dance as an ungraspable event towards conceiving of dance as a tangible process that can be collected, transmitted, repeated and packaged or archived as an object. I look at two dance works – Matthias Sperling’s Loop Atlas and Siobhan Davies and Anri Sala’s Solo in the Doldrums – that trouble conventional notions of embodiment and its relationship to both presence and absence, at the same time they challenge how computational media fixates on figures and gestures that can be traced, mapped and calibrated.
Predicting motor gains with home-based telerehabilitation after stroke
Authors: Paik Sang Min , Cramer Steven C 
Published: June 2021

Introduction Telerehabilitation (TR) may be useful for rehabilitation therapy after stroke. However, stroke is a heterogeneous condition, and not all patients can be expected to derive the same benefit from TR, underscoring the need to identify predictors of response to TR. Methods A prior trial provided patients with 6 weeks of intensive rehabilitation therapy targeting arm movement, randomly assigned to be provided in the home via TR (current focus) or in clinic. Eligible patients had moderate arm motor deficits and were in the subacute–chronic stage post stroke. Behavioral gains were measured as change in the arm motor Fugl-Meyer score from baseline to 30 days post therapy. To delineate predictors of TR response, multivariable linear regression was performed, advancing the most significant predictor from each of eight categories: patient demographics, stroke characteristics, medical history, rehabilitation therapy outside of study procedures, motivation, sensorimotor impairment, cognitive/affective deficits, and functional status. Results The primary focus was on patients starting TR >90 days post stroke onset ( n = 44), among whom female sex, less spasticity, and less visual field defects predicted greater motor gains. This model explained 39.3% of the variance in treatment-related gains. In secondary analysis that also included TR patients enrolled ≤90 days post stroke (total n = 59), only female sex was a predictor of treatment gains. A separate secondary analysis examined patients >90 days post stroke ( n = 34) randomized to in-clinic therapy, among whom starting therapy earlier post stroke and less ataxia predicted greater motor gains. Discussion Response to TR varies across patients, emphasizing the need to identify characteristics that predict treatment-related behavioral gain. The current study highlights factors that might be important to patient selection for home-based TR after stroke.
Self-reported parkinsonism features in older autistic adults: A descriptive study
Authors: Geurts Hilde M , McQuaid Goldie A , Begeer Sander , Wallace Gregory L 
Published: June 2021

Prior research suggests that autistic adults are at increased risk for developing the core motor components of Parkinson’s disease (i.e. parkinsonism) although knowledge is limited to date. Therefore, we explore: (1) the prevalence of both continuous self-reported motor features typical of parkinsonism and the screen positivity rate for parkinsonism in two samples of older autistic adults without a suspected intellectual disability: the Netherlands-Sample ( N = 296, 50–81 years; 183 males; 113 females) and the United States of America-Sample ( N = 209, 50–83 years; 100 males; 109 females), and (2) whether there are differences between those who Screen+ versus Screen− for parkinsonism. Within the Netherlands-Sample only, the age of onset of the motor features was investigated. Self-reported parkinsonism features were prevalent in both samples (the Netherlands-Sample ~17% screened positive, mean age of onset ranging from 35.9 to 50.4 years; the United States of America-Sample ~33% screened positive). Autistic adults (the Netherlands-Sample) screening positive encountered more health problems than those who screened negative. In both samples, autistic adults who screened positive did not differ on current antipsychotic medication use relative to those who screened negative. The next step is to determine whether a positive screen for parkinsonism on this self-report questionnaire also implies that there is a higher risk for idiopathic Parkinson’s disease. Lay abstract Autistic adults without a suspected intellectual disability reported several motor features such as having tremors, and stiffness in one’s legs which are considered to be part of a complex of motor features called parkinsonism. This so-called parkinsonism was remarkably prevalent in middle-aged and older autistic adults in two independent studies (Dutch study: 50–81 years, 183 males, 113 females, all adulthood diagnoses; the USA study: 50–83 years, 110 females, 109 males, majority adulthood diagnosis). Parkinsonism can be part of the progressive motor disease—Parkinson’s disease. Therefore, it is important that future studies, including in-person neurological assessment, determine if (and if so, why) autistic adults who report these motor features are at increased risk for developing Parkinson’s disease.
A method for the experimental estimation of direct and cross-coupled dynamic coefficients of tilting-pad journal bearings of vertical hydro-generators
Authors: Brito Geraldo C , Machado Roberto D , Neto Anselmo C , Kimura Leonardo Y 
Published: June 2021

This article presents a method to experimentally estimate the direct and cross-coupled dynamic coefficients of tilting-pad journal bearings of vertical hydro-generators and other similar rotating machinery for damage detection purposes. Based on a simplified second-order model of a journal bearing in the state-space, the method employs only the usually monitored vibrations, the shaft radial relative, and the bearing radial absolute vibrations originated by the hydro-generator residual unbalance or by hydraulic excitations in the turbine rotor. This article shows that the method was successfully tested using the shaft and bearing vibration signals synthesized by a mathematical model of a 700 MW hydro-generator, even when these signals are contaminated with random noise. This article also shows the method’s performance when applied to real vibration signals acquired from the modeled hydro-generator. Finally, it discusses the possible measures to improve the method’s efficiency.
Patient functional independence and occupational therapist time-use in inpatient services: Patient demographic and clinical correlates
Authors: Summers Bianca E , Laver Kate E , Nicks Rebecca J , Andrew Nadine E , Barr Christopher J , Jolliffe Laura , Lannin Natasha A 
Published: June 2021

Introduction Health care expenditure has rapidly increased in Australia. Effective management of occupational therapy services is required to meet clinical demand. Improving our understanding of factors which influence occupational therapy service delivery is a vital step to manage workload distribution and optimise service efficiency. This study aims to examine the influence of patient sociodemographic characteristics, diagnosis and functional independence on the utilisation of occupational therapy resources in hospital inpatients over 18 years old. Methods Prospective, cross-sectional, observational cohort study of 4549 inpatients from three hospital sites in Melbourne, Australia. Data extracted from organisational databases and included in this study were: patient demographics, diagnosis, functional level assessed using the SMAF (Functional Autonomy Measurement System) and occupational therapy time-use. Data were analysed using univariable and multivariable modelling. Results Occupational therapy time-use was significantly associated with all variables included in analysis ( p < 0.05). For each variable the amount and direction of effect differed between hospital sites. The SMAF was the only variable consistently associated with occupational therapy time-use. Higher occupational therapy time-use was associated with lower functional independence (leading to a 3.5 min increase in median occupational therapy time for every unit decrease in SMAF score). Conclusions Management of resources within busy hospitals require knowledge of factors associated with occupational therapist time-use. This study identified that time-use could in part be predicted by functional independence, diagnosis and sociodemographic characteristics. Occupational therapy managers can use this information to support decision making while acknowledging other patient and therapist level factors also influence time-use.
Vertebral Compression Fractures—The First Manifestations in the Elderly Acute Lymphoblastic Leukemia
Authors: Liu Cheng , Shu Cuili 
Published: June 2021

Background: Acute lymphoblastic leukemia (ALL) is reported to be the most common malignancy in children, but is less common in adults. Though vertebral compression fractures have been reported as initial signs of ALL in children, to the best of our knowledge, there have not been any previous reports of vertebral compression fractures as an initial manifestation of ALL in elderly people. Case Presentation: Here we reported a 65-year-old man who was admitted with a 1-month history of progressive chest and back pain and worsening pain after heavy lifting. Considering the histories of osteoporosis, minor trauma and normal peripheral blood counts, it was firstly misdiagnosed as spinal osteoporotic compression fractures which were caused by low-energy injuries. The patient was definitely diagnosed as ALL after bone marrow biopsy. Conclusion: ALL must be considered in the differential diagnosis with acute vertebral compression fracture. Considering that bony lesions may precede clinical findings, knowledge of radiographic and orthopedic appearances of leukemia are important in order to initiate earlier treatment to avoid the progressive damage and improve their survival rates. we recommend bone marrow biopsy in vertebroplasty to avoid misdiagnosis.
Cohesin mutations in myeloid malignancies
Authors: Jann Johann-Christoph , Tothova Zuzana 
Published: June 2021

Abstract
Cohesin is a multisubunit protein complex that forms a ring-like structure around DNA. It is essential for sister chromatid cohesion, chromatin organization, transcriptional regulation, and DNA damage repair and plays a major role in dynamically shaping the genome architecture and maintaining DNA integrity. The core complex subunits STAG2, RAD21, SMC1, and SMC3, as well as its modulators PDS5A/B, WAPL, and NIPBL, have been found to be recurrently mutated in hematologic and solid malignancies. These mutations are found across the full spectrum of myeloid neoplasia, including pediatric Down syndrome–associated acute megakaryoblastic leukemia, myelodysplastic syndromes, chronic myelomonocytic leukemia, and de novo and secondary acute myeloid leukemias. The mechanisms by which cohesin mutations act as drivers of clonal expansion and disease progression are still poorly understood. Recent studies have described the impact of cohesin alterations on self-renewal and differentiation of hematopoietic stem and progenitor cells, which are associated with changes in chromatin and epigenetic state directing lineage commitment, as well as genomic integrity. Herein, we review the role of the cohesin complex in healthy and malignant hematopoiesis. We discuss clinical implications of cohesin mutations in myeloid malignancies and discuss opportunities for therapeutic targeting.