bluuebunny/crossref_metadata_2025_split huggingface dataset:
General rogue waves in the three-wave resonant interaction systems
Authors: Yang Bo , Yang Jianke 
Published: February 2021

Abstract
General rogue waves in (1+1)-dimensional three-wave resonant interaction systems are derived by the bilinear method. These solutions are divided into three families, which correspond to a simple root, two simple roots and a double root of a certain quartic equation arising from the dimension reduction, respectively. It is shown that while the first family of solutions associated with a simple root exists for all signs of the nonlinear coefficients in the three-wave interaction equations, the other two families of solutions associated with two simple roots and a double root can only exist in the so-called soliton-exchange case, where the nonlinear coefficients have certain signs. Many of these rogue wave solutions, such as those associated with two simple roots, the ones generated by a $2\times 2$ block determinant in the double-root case, and higher-order solutions associated with a simple root, are new solutions which have not been reported before. Technically, our bilinear derivation of rogue waves for the double-root case is achieved by a generalization to the previous dimension reduction procedure in the bilinear method, and this generalized procedure allows us to treat roots of arbitrary multiplicities. Dynamics of the derived rogue waves is also examined, and new rogue wave patterns are presented. Connection between these bilinear rogue waves and those derived earlier by Darboux transformation is also explained.
Gender, Justice and Deliberation: Why Women Don't Influence Peacemaking
Authors: Kostovicova Denisa , Paskhalis Tom 
Published: February 2021

AbstractScholars have pinpointed that women's underrepresentation in peacemaking results in gendered outcomes that do not address women's needs and interests. Despite recent increased representation at the negotiating table, women still have a limited influence on peacemaking outcomes. We propose that differences in female and male speeches reflected in the gendered patterns in discourse during peacemaking explain how women's influence is curtailed. We examine women's speaking behavior in transitional justice debates in the post-conflict Balkans. Applying multimethod quantitative text analysis to over half a million words in multiple languages, we analyze structural and thematic speech patterns. We find that men's domination of turn-taking and the absence of topics reflecting women's needs and interests lead to a gendered outcome. The sequences of men talking after men are longer than those of women talking after women, which restricts women's deliberative space and opportunities to develop and sustain arguments that reflect their concerns. We find no evidence that women's limited influence is driven by lower deliberative quality of their speeches. This study of gendered dynamics at the microlevel of discourse identifies a novel dimension of male domination during peacemaking.
Educational Strategies to Achieve Equitable Breast Imaging Care
Authors: Davis Katie M , Monga Natasha , Sonubi Chiamaka , Asumu Hazel , DeBenedectis Carolynn M , Spalluto Lucy B 
Published: February 2021

Abstract
As the population of the United States becomes increasingly diverse, radiologists must learn to both understand and mitigate the impact of health disparities. Significant health disparities persist in radiologic care, including breast imaging. Racial and ethnic minorities, women from lower socioeconomic status, those living in rural areas, and the uninsured bear a disproportionate burden of breast cancer morbidity and mortality. Currently, there is no centralized radiology curriculum focusing on breast health disparities available to residents, breast imaging fellows, or practicing breast radiologists. While patient-, provider-, and system-level initiatives are necessary to overcome disparities, our purpose is to describe educational strategies targeted to breast imaging radiologists at all levels to provide equitable care to a diverse population. These strategies may include, but are not limited to, diversifying the breast imaging workforce, understanding the needs of a diverse population, cultural sensitivity and bias training, and fostering awareness of the existing issues in screening mammography access, follow-up imaging, and clinical care.
Cosmic rays across the star-forming galaxy sequence – II. Stability limits and the onset of cosmic ray-driven outflows
Authors: Crocker Roland M , Krumholz Mark R , Thompson Todd A 
Published: February 2021

ABSTRACT
Cosmic rays (CRs) are a plausible mechanism for launching winds of cool material from the discs of star-forming galaxies. However, there is no consensus on what types of galaxies likely host CR-driven winds, or what role these winds might play in regulating galaxies’ star formation rates. Using a detailed treatment of the transport and losses of hadronic CRs developed in the previous paper in this series, here we develop a semi-analytical model that allows us to assess the viability of using CRs to launch cool winds from galactic discs. In particular, we determine the critical CR fluxes – and corresponding star formation rate surface densities – above which hydrostatic equilibrium within a given galaxy is precluded because CRs drive the gas off in a wind or otherwise render it unstable. Our model demonstrates that catastrophic, CR-driven wind loss is a possibility at galactic mean surface densities below ${\lesssim}10^2 \ \mathrm{ M}_{\odot }$ pc−2. In this regime – encompassing the Galaxy and local dwarfs – the locus of the CR-stability curve patrols the high side of the observed distribution of galaxies in the Kennicutt–Schmidt parameter space of star formation rate versus gas surface density. However, hadronic losses render CRs unable to drive global winds in galaxies with surface densities above the ∼102−103 M⊙ pc−2 transition region. Our results show that quiescent, low surface density galaxies like the Milky Way are poised on the cusp of instability, such that small changes to interstellar mass (ISM) parameters can lead to the launching of CR-driven outflows, and we suggest that, as a result, CR feedback sets an ultimate limit to the star formation efficiency of most modern galaxies.
Sturnira hondurensis(Chiroptera: Phyllostomidae)
Authors: Hernández-Canchola Giovani , Ortega Jorge , León-Paniagua Livia 
Published: February 2021

AbstractThe Honduran yellow-shouldered bat (Sturnira hondurensis Goodwin, 1940) is a medium-sized Stenodermatinae with a vestigial uropatagium and no tail; it typically has reddish or yellowish patches on the shoulders. It is found in temperate habitats from Mexico to northern Nicaragua, and it is one of 24 described species of the genus Sturnira. S. hondurensis is considered a common species and is listed as “Least Concern” (LC) by the International Union for Conservation of Nature and Natural Resources. Nevertheless, it primarily depends on the preservation of native and continuous forest, so maintaining the connectivity of vegetation patches and the availability of food in modified landscapes are strategies for the preservation of S. hondurensis and the ecosystem services that it provides.
Long-read sequencing and de novo genome assemblies reveal complex chromosome end structures caused by telomere dysfunction at the single nucleotide level
Authors: Kim Eunkyeong , Kim Jun , Kim Chuna , Lee Junho 
Published: February 2021

Abstract
Karyotype change and subsequent evolution is triggered by chromosome fusion and rearrangement events, which often occur when telomeres become dysfunctional. Telomeres protect linear chromosome ends from DNA damage responses (DDRs), and telomere dysfunction may result in genome instability. However, the complex chromosome end structures and the other possible consequences of telomere dysfunction have rarely been resolved at the nucleotide level due to the lack of the high-throughput methods needed to analyse these highly repetitive regions. Here we applied long-read sequencing technology to Caenorhabditis elegans survivor lines that emerged after telomere dysfunction. The survivors have preserved traces of DDRs in their genomes and our data revealed that variants generated by telomere dysfunction are accumulated along all chromosomes. The reconstruction of the chromosome end structures through de novo genome assemblies revealed diverse types of telomere damage processing at the nucleotide level. When telomeric repeats were totally eroded by telomere dysfunction, DDRs were mostly terminated by chromosome fusion events. We also partially reconstructed the most complex end structure and its DDR signatures, which would have been accumulated via multiple cell divisions. These finely resolved chromosome end structures suggest possible mechanisms regarding the repair processes after telomere dysfunction, providing insights into chromosome evolution in nature.
Is There Still a Place for Tocilizumab in Coronavirus Disease 2019?
Authors: Klopfenstein Timothée , Conrozier Thierry , Kadiane-Oussou N’dri Juliette , Gendrin Vincent , Zayet Souheil 
Published: February 2021

AbstractIn this article, we sought to summarize the available evidence of tocilizumab as a treatment for coronavirus disease 2019. Recent tocilizumab randomized trials have not shown clear evidence of efficacy, especially on mortality, in contrast to observational studies. These clinical trials focus on a heterogeneous population of patients (clinical severity and inflammatory stage), and this is possibly one of the reasons that explain heterogeneity of results. However, these same trials have shown some evidence that tocilizumab may reduce intensive care unit admissions and/or mechanical ventilation incidence, which are huge challenges in the severe acute respiratory syndrome coronavirus 2 pandemic. Future clinical trials with primary endpoint built on this assumption are needed (1) to confirm whether tocilizumab reduces mechanical ventilation requirement and (2) to describe the right patient population and optimal timing for tocilizumab administration. Finding the optimal timing for tocilizumab administration and the group of patients who are susceptible to having the greatest benefit are probably the main challenge.
The ubiquitin E3 ligase SR1 modulates the submergence response by degrading phosphorylated WRKY33 in Arabidopsis
Authors: Liu Bao , Jiang Yuanzhong , Tang Hu , Tong Shaofei , Lou Shangling , Shao Chen , Zhang Junlin , Song Yan , Chen Ningning , Bi Hao , Zhang Han , Li Junhua , Liu Jianquan , Liu Huanhuan 
Published: February 2021

Abstract
Oxygen deprivation caused by flooding activates acclimation responses to stress and restricts plant growth. After experiencing flooding stress, plants must restore normal growth; however, which genes are dynamically and precisely controlled by flooding stress remains largely unknown. Here, we show that the Arabidopsis thaliana ubiquitin E3 ligase SUBMERGENCE RESISTANT1 (SR1) regulates the stability of the transcription factor WRKY33 to modulate the submergence response. SR1 physically interacts with WRKY33 in vivo and in vitro and controls its ubiquitination and proteasomal degradation. Both the sr1 mutant and WRKY33 overexpressors exhibited enhanced submergence tolerance and enhanced expression of hypoxia-responsive genes. Genetic experiments showed that WRKY33 functions downstream of SR1 during the submergence response. Submergence induced the phosphorylation of WRKY33, which enhanced the activation of RAP2.2, a positive regulator of hypoxia-response genes. Phosphorylated WRKY33 and RAP2.2 were degraded by SR1 and the N-degron pathway during reoxygenation, respectively. Taken together, our findings reveal that the on-and-off module SR1-WRKY33-RAP2.2 is connected to the well-known N-degron pathway to regulate acclimation to submergence in Arabidopsis. These two different but related modulation cascades precisely balance submergence acclimation with normal plant growth.
Parental variation in CHG methylation is associated with allelic-specific expression in elite hybrid rice
Authors: Ma Xuan , Xing Feng , Jia Qingxiao , Zhang Qinglu , Hu Tong , Wu Baoguo , Shao Lin , Zhao Yu , Zhang Qifa , Zhou Dao-Xiu 
Published: February 2021

Abstract
Heterosis refers to the superior performance of hybrid lines over inbred parental lines. Besides genetic variation, epigenetic differences between parental lines are suggested to contribute to heterosis. However, the precise nature and extent of differences between the parental epigenomes and the reprograming in hybrids that govern heterotic gene expression remain unclear. In this work, we analyzed DNA methylomes and transcriptomes of the widely cultivated and genetically studied elite hybrid rice (Oryza sativa) SY63, the reciprocal hybrid, and the parental varieties ZS97 and MH63, for which high-quality reference genomic sequences are available. We showed that the parental varieties displayed substantial variation in genic methylation at CG and CHG (H = A, C, or T) sequences. Compared with their parents, the hybrids displayed dynamic methylation variation during development. However, many parental differentially methylated regions (DMRs) at CG and CHG sites were maintained in the hybrid. Only a small fraction of the DMRs displayed non-additive DNA methylation variation, which, however, showed no overall correlation relationship with gene expression variation. In contrast, most of the allelic-specific expression (ASE) genes in the hybrid were associated with DNA methylation, and the ASE negatively associated with allelic-specific methylation (ASM) at CHG. These results revealed a specific DNA methylation reprogramming pattern in the hybrid rice and pointed to a role for parental CHG methylation divergence in ASE, which is associated with phenotype variation and hybrid vigor in several plant species.
A Randomized, Controlled, Crossover Trial of Virtual Reality in Maintenance Cardiovascular Rehabilitation in a Low-Resource Setting: Impact on Adherence, Motivation, and Engagement
Authors: da Cruz Mayara Moura Alves , Ricci-Vitor Ana Laura , Borges Giovanna Lombardi Bonini , da Silva Paula Fernanda , Turri-Silva Natália , Takahashi Carolina , Grace Sherry L , Vanderlei Luiz Carlos Marques 
Published: February 2021

Abstract

Objective
The purpose of this study was to investigate the effects of adding virtual reality (VR) to maintenance cardiac rehabilitation (CR); it was hypothesized VR would increase adherence, motivation, and engagement.

Methods
This study was a randomized, 1:1 concealed-allocation, single-blinded, 2 parallel-arm, crossover trial. Blinded assessments were undertaken at baseline (midprogram), 12 weeks, and 24 weeks after baseline. The setting was a single CR program of unlimited duration in Brazil. Participants were patients with cardiovascular diseases or risk factors who had been in the program for 3 months or longer. The CR program consisted of 3 supervised exercise sessions per week. In the VR arm, participants had 1 VR session of the 3 per week during the initial 12 weeks of the trial; this was withdrawn the subsequent 12 weeks. Measures were program adherence (% of 3 sessions/week over 12 weeks, ascertained in all participants), motivation (Behavioral Regulation in Exercise Questionnaire 3), and engagement (User Engagement Scale, adapted; vigor, dedication, and absorption subscales); all 3 were primary outcomes.

Results
Sixty-one (83.6%) patients were randomly assigned (n = 30 to CR + VR); 54 (88.5%) were retained at 12 and 24 weeks. At baseline, participants had been in CR on average 7 years and had high engagement and motivation. CR + VR resulted in a significant increase in adherence at 12 weeks (baseline = 72.87%; 12 weeks = 82.80%), with significant reductions at 24 weeks when VR was withdrawn (65.48%); in the usual CR care arm, there were no changes over time. There was a significant effect for arm, with significantly higher adherence in the CR + VR arm than usual CR at 12 weeks (73.51%). Motivation decreased significantly from baseline to 12 weeks (4.32 [SD = 0.37] vs 4.02 [SD = 0.76]) and significantly increased from 12 to 24 weeks in the CR + VR arm (4.37 [SD = 0.36]). Absorption was significantly lower at 12 weeks in the CR + VR arm (6.79 [SD = 0.37] vs 6.20 [SD = 1.01]).

Conclusion
Although VR increased program adherence, interspersing it with usual CR sessions actually decreased patient motivation and absorption.

Impact
Supplementing a maintenance CR program with VR using “exergames” resulted in significantly greater adherence (8% increase or 3 of 36 sessions), and this was quite a robust effect given it was extinguished with the removal of VR. However, contrary to the hypotheses, offering 1 session of VR per week and 2 of usual CR exercise was related to lower motivation and absorption, which has implications for how clinicians design programs for this patient population.
Do Index Funds Monitor?
Authors: Heath Davidson , Macciocchi Daniele , Michaely Roni , Ringgenberg Matthew C 
Published: February 2021

Abstract
Passively managed index funds now hold over 30$\%$ of U.S. equity fund assets; this shift raises fundamental questions about monitoring and governance. We show that, relative to active funds, index funds are less effective monitors: (a) they are less likely to vote against firm management on contentious governance issues; (b) there is no evidence they engage effectively publicly or privately; and (c) they promote less board independence and worse pay-performance sensitivity at their portfolio companies. Overall, the rise of index funds decreases the alignment of incentives between beneficial owners and firm management and shifts control from investors to managers.
Induction of narcolepsy-like symptoms by orexin receptor antagonists in mice
Authors: Kaushik Mahesh K , Aritake Kosuke , Cherasse Yoan , Imanishi Aya , Kanbayashi Takashi , Urade Yoshihiro , Yanagisawa Masashi 
Published: February 2021

AbstractOrexins/hypocretins are hypothalamic neuropeptides that promote and stabilize wakefulness by binding to the orexin receptor type-1 (OX1R) and type-2 (OX2R). Disruption of orexinergic signaling results in the sleep disorder narcolepsy in mice, rats, dogs, and humans. The orexin receptor antagonist suvorexant promotes sleep by blocking both OX1R and OX2R. Whereas suvorexant has been clinically approved for the treatment of insomnia because it is well tolerated in experimental animals as well as in human patients, a logical question remains as to why orexin receptor antagonists do not induce overt narcolepsy-like symptoms. Here we show that acute and chronic suvorexant promotes both rapid eye movement (REM) and non-rapid eye movement (NREM) sleep without inducing cataplexy in mice. Interestingly, chronic suvorexant increases OX2R mRNA and decreases orexin mRNA and peptide levels, which remain low long after termination of suvorexant administration. When mice are chronically treated with suvorexant and then re-challenged with the antagonist after a 1-week washout, however, cataplexy and sleep-onset REM (SOREM) are observed, which are exacerbated by chocolate administration. Heterozygous orexin knockout mice, with lower brain orexin levels, show cataplexy and SOREM after acute suvorexant administration. Furthermore, we find that acute suvorexant can induce cataplexy and SOREM in wild-type mice when co-administered with chocolate under stress-free (temporally anesthetized) conditions. Taken together, these results suggest that suvorexant can inhibit orexin synthesis resulting in susceptibility to narcolepsy-like symptoms in mice under certain conditions.
Integrating Early Brain Science and Skills Into Prelicensure Nursing Curriculum to Promote Parent-Child Interaction
Authors: Brasher Susan , Becklenberg Amy , Darcy Mahoney Ashley , Ross Kimberly , Stapel-Wax Jennifer L. 
Published: February 2021

Background
Research shows that the number of loving words children hear in their first 3 years of life has a tremendous impact on their health, developmental, and literacy outcomes. Early language transactions should be rich in engagement, quantity, quality, and context—a term called language nutrition.

Problem
The curriculum in most nursing programs does not emphasize the importance of early language exposure and ways to empower families to talk with their babies.

Approach
The Talk With Me Baby Curriculum for Nurses, which includes techniques to empower families to better engage conversationally with their babies, was integrated into the prelicensure nursing curriculum.

Outcomes
More than 1,300 nursing students have received knowledge and skills on early language exposure and ways nurses can promote parent-child interactions.

Conclusion
Nurses have the opportunity to empower families to engage with their babies socially, emotionally, and linguistically as a means of promoting healthy brain development.
The Therapeutic Value of Hydralazine in Reducing Inflammatory Response, Oxidative Stress, and Mortality in Animal Sepsis: Involvement of the PI3K/AKT Pathway
Authors: Santos Danillo Menezes dos , Da Silva Eric Aian Pereira , Oliveira Jeferson Yuri Santos , Marinho Yandra Yssa de Menezes , Santana Izabel Rodrigues de , Heimfarth Luana , Pereira Erik Willyame Menezes , Júnior Lucindo José Quintans , Assreuy Jamil , Menezes Igor Alexandre Cortes , Santos Márcio Roberto Viana dos 
Published: February 2021

ABSTRACT
Sepsis is an amplified systemic immune-inflammatory response produced by a microorganism, which involves activation of inflammatory cytokine signaling pathways and oxidative stress. A variety of studies have shown that hydralazine (HDZ) has potent antioxidant and anti-inflammatory proprieties. Therefore, we hypothesize that HDZ can improve the clinical outcome of sepsis. Thus, this work aimed to evaluate therapeutic value of HDZ in reducing inflammatory response, oxidative stress, and mortality in animal sepsis, and to investigate its possible mechanism of action. Sepsis was induced by the cecal ligation and puncture (CLP) method in Wistar rats. After surgery, the animals were randomly divided into three groups: sham, sepsis, and sepsis + HDZ (1 mg/kg, s.c.). All groups were monitored for 48 h to assess survival rate, and clinical, hemodynamic, biochemical, and cellular parameters. After euthanasia, blood, spleen, liver, and kidneys were collected for analysis. Blood serum cytokines, tissue myeloperoxidase (MPO) activity, and oxidative stress parameters were assessed. Involvement of the PI3K/Akt pathway was also investigated. Sepsis was successfully induced by the CLP technique. HDZ treatment increased the survival rate (from 50% to 90%), improved glycemia control, reduced the clinical severity sepsis and mean arterial pressure; and prevented increased MPO activity, TNF-α, IL-1β, IL-10 levels, and oxidative damage markers. Additionally, HDZ significantly prevented the increase of Akt activation in the liver and kidney. HDZ largely mitigated the effects of sepsis by suppressing inflammatory and antioxidant responses via the PI3K/Akt pathway. These findings provide evidence that HDZ can be a new therapeutic alternative for treating sepsis.