bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kaempferol inhibits the cell migration of human hepatocellular carcinoma cells by suppressing MMP‐9 and Akt signaling
Authors: Ju Po‐Chung , Ho Yung‐Chuan , Chen Pei‐Ni , Lee Hsiang‐Lin , Lai Szu‐Yu , Yang Shun‐Fa , Yeh Chao‐Bin 
Published: June 2021

AbstractMetastasis is the most prevalent cause of cancer‐related deaths and treatment failure in patients with hepatocellular carcinoma (HCC). Kaempferol is a natural flavonol belonging to the subgroup of flavonoids and exhibits potent anticancer activities. This study provides molecular evidence on the anti‐invasive and anti‐migratory effects of kaempferol on human HCC cells. The anti‐invasive effect was investigated by applying kaempferol on two human HCC cell lines (Huh‐7 and SK‐Hep‐1). Kaempferol reduced the invasion and migration of Huh‐7 and SK‐Hep‐1 cells by Boyden chamber invasion assay and wound healing assay, respectively. A protease array analysis showed that Matrix Metalloproteinase‐9 (MMP‐9) was dramatically downregulated in HCC cells after kaempferol treatment. Gelatin zymography and Western blot assay showed that kaempferol reduced the activities and protein expression of MMP‐9, respectively. Kaempferol also sufficiently suppressed the phosphorylation of the Akt expression. Overall, kaempferol inhibited the invasive properties of human HCC cells by targeting MMP‐9 and Akt pathways. Hence, kaempferol could be used as an adjuvant therapeutic agent for the treatment of human HCC cells.
FADE: A forensic image generator for android device education
Authors: Ceballos Delgado Alberto A. , Glisson William B. , Grispos George , Choo Kim‐Kwang Raymond 
Published: June 2021

AbstractRealistic case studies are essential to training successful digital forensics examiners. However, the generation of realistic datasets is time‐consuming and resource taxing. This paper presents a technical solution that populates Android emulators with realistic mobile forensic data. The emulator's data can be extracted into a raw disk image that is usable in mobile forensic training scenarios. In addition, the tool allows a user to populate the Android emulators with custom text messages, phone contacts, phone calls, and files. This population task is achieved by utilizing the Android Debug Bridge, Android Content Providers, SQLite databases, and the NodeJS runtime environment. This paper presents the software design and development, the requirements and limitations, and the testing process implemented in this research. The contribution of this paper is twofold. First, it identifies potential data and mechanisms to generate Android mobile forensic datasets using customized data population. Second, it creates a foundation for future research on the topic of mobile forensic emulators for training purposes.This article is categorized under:
Digital and Multimedia Science > Mobile Forensics
Crime Scene Investigation > Education and Formation
Contemporary short-term outcomes of surgery for aortic stenosis: transcatheter vs. surgical aortic valve replacement
Authors: Saito Shunsuke , Sairenchi Toshimi , Tezuka Masahiro , Takei Yusuke , Tsuchiya Go , Ogata Koji , Monta Osamu , Shibasaki Ikuko , Tsutsumi Yasushi , Fukuda Hirotsugu 
Published: June 2021

Abstract
Objectives
This study aimed to compare the short-term outcomes of transcatheter and surgical aortic valve replacements (TAVR and SAVR) in high-, intermediate-, and low-preoperative risk patients.

Methods
A total of 454 patients who underwent TAVR or SAVR were included. Patients were categorized into high-, intermediate-, and low-risk according to the Society of Thoracic Surgery-Predicted Risk of Mortality score and clinical outcomes were compared between TAVR and SAVR groups.

Results
TAVR was less invasive, with less bleeding and transfusion (p < 0.001), less frequent new-onset atrial fibrillation (p < 0.001), and shorter intensive care unit stay (p < 0.001). Furthermore, transcatheter valves performed better than surgical valves, with lower peak velocity (p = 0.003) and pressure gradient (p < 0.001) and higher effective orifice area index (p < 0.001). The clinical outcomes of TAVR were comparable to or even superior to those of SAVR in high- and intermediate-risk patients. In low-risk patients, the 1- and 2-year mortality rates were 6.3% and 12.1%, respectively, in the TAVR group and 0% and 0.9%, respectively, in the SAVR group (p < 0.001). Mild or greater paravalvular leakage was a risk factor for mortality (hazard ratio 35.78; p < 0.001).

Conclusions
TAVR was superior to SAVR in the sense of less invasiveness and valvular function. However, the indication of TAVR in low-risk patients should be carefully discussed, because paravalvular leakage was a risk factor for short-term mortality.
Appropriateness of aspirin prescribing for primary and secondary prevention of cardiovascular disease in type 2 diabetes in different care settings
Authors: Tan Shi Ying , Cronin Heather , Byrne Stephen , O’Donovan Adrian , Tuthill Antoinette 
Published: June 2021

Abstract
Background
Type 2 diabetes is associated with an increased cardiovascular risk. Use of aspirin has been shown to be of benefit for secondary prevention of cardiovascular disease in patients with type 2 diabetes; benefits in primary prevention have not been clearly proven.

Aims
This study aims to (a) determine if aspirin is prescribed appropriately in type 2 diabetes for primary or secondary prevention of cardiovascular disease (CVD) and (b) evaluate whether there are differences in aspirin prescribing according to where people receive their care.

Design
Cross-sectional study

Methods
The medical records of individuals with type 2 diabetes aged over 18 years and attending Elmwood Primary Care Centre and Cork University Hospital Diabetes outpatient clinics (n = 400) between February and August 2017 were reviewed.

Results
There were 90 individuals exclusively attending primary care and 310 persons attending shared care. Overall, 49.0% (n = 196) of those were prescribed aspirin, of whom 42.3% were using it for secondary prevention. Aspirin was used significantly more in people attending shared care (p < 0.001). About 10.8% of individuals with diabetes and CVD attending shared care met guidelines for, but were not prescribed aspirin.

Conclusion
A significant number of people with type 2 diabetes who should have been prescribed aspirin for secondary prevention were not receiving it at the time of study assessment. In contrast, a substantial proportion who did not meet criteria for aspirin use was prescribed it for primary prevention.
Affective commitment through further training: the roles of firm provision and employee participation
Authors: Grund Christian , Titz Krystina 
Published: June 2021

AbstractThis study investigates the relation of further training and employees’ affective commitment by disentangling the relevance of a firm’s general support for further training and the individual’s actual participation. Using linked employer-employee data, we consider both the firm’s and the individual’s perspective and control for several HR instruments additionally to the usual demographics and job characteristics. We also distinguish between subgroups of employees regarding age and schooling. Results show that employees’ participation in further training and a firm’s support for further training are both positively related to affective commitment. Furthermore, our results hint for differences in employees’ expectations regarding the amount of the firm’s support for further training. Whereas there is no meaningful relation of the general firm’s support for further training to commitment of university graduates, participation in further training measures and the individuals’ perceived support for personnel development is particularly relevant for this group of employees.
Plant disease severity estimated visually: a century of research, best practices, and opportunities for improving methods and practices to maximize accuracy
Authors: Bock Clive H. , Chiang Kuo-Szu , Del Ponte Emerson M. 
Published: June 2021

AbstractPlant disease quantification, mainly the intensity of disease symptoms on individual units (severity), is the basis for a plethora of research and applied purposes in plant pathology and related disciplines. These include evaluating treatment effect, monitoring epidemics, understanding yield loss, and phenotyping for host resistance. Although sensor technology has been available to measure disease severity using the visible spectrum or other spectral range imaging, it is visual sensing and perception that still dominates, especially in field research. Awareness of the importance of accuracy of visual estimates of severity began in 1892, when Cobb developed a set of diagrams as an aid to guide estimates of rust severity in wheat. Since that time, various approaches, some of them based on principles of psychophysics, have provided a foundation to understand sources of error during the estimation process as well as to develop different disease scales and disease-specific illustrations indicating the diseased area on specimens, similar to that developed by Cobb, and known as standard area diagrams (SADs). Several rater-related (experience, inherent ability, training) and technology-related (instruction, scales, and SADs) characteristics have been shown to affect accuracy. This review provides a historical perspective of visual severity assessment, accounting for concepts, tools, changing paradigms, and methods to maximize accuracy of estimates. A list of best-operating practices in plant disease quantification and future research on the topic is presented based on the current knowledge.
Mental Health, Crime, Sport, Community, and Island Life: The Post-Retirement Struggles of a Fiji Soccer Hero
Authors: James Kieran , Nadan Yogesh 
Published: June 2021

AbstractThis article explores the soccer career of the ex-Fiji national-team player, Henry Dyer, and his post-retirement struggles. He experiences ‘fragmentation’ because of two ‘epiphanies’ (traumatic life-events)—his failure to get an elite coaching job after retirement and failure to secure an overseas playing-contract. After a period of fragmentation, when he cut all ties with the sport, he has reinvented himself as a caring person who, through the social and support club, Nadi Legends Club, visits ex-players going through illness. We also use Henry’s story as a gateway to explore (1) race and class aspects; and (2) masculinity issues. We look at the case through the theoretical lenses of symbolic interactionism and Foucault on power.
A Thesaurus of English Dialect and Slang
Authors: Robinson Jonnie 
Published: June 2021

A thesaurus of present-day vernacular English from Berwick-upon-Tweed to the Channel Islands, this unique record of everyday English celebrates established regional dialects, emerging new varieties and colloquial forms young and old. Based on a prestigious nationwide survey, BBC Voices Recordings, it documents the linguistic landscape of England, Wales and the Channel Islands in the 21st century, and includes over 3000 separate entries, drawn from over 200 locations across the country. Each entry contains information about the term's origins, location and the social distribution of its users. With links to original sound files and cross-references to complementary dictionary sources, it is an authoritative reference work for academic linguists, but its accessible presentation also makes it suitable for creative audiences and non-specialist language enthusiasts seeking authentic, up-to-date information on British English dialect and slang, and for English language teachers and learners as an invaluable educational tool.
A Decade of the UNGPs in India: Progressive Policy Shifts, Contested Implementation
Authors: SRINIVASAN Vasanthi , VENKATACHALAM Parvathy 
Published: June 2021

AbstractThe decade of the United Nations Guiding Principles on Business and Human Rights (UNGPs) coincides with India’s National Voluntary Guidelines on businesses’ social, environmental, and economic responsibilities (NVGs) and the National Guidelines on Responsible Business Conduct (NGRBC) – an updated version of the NVGs. Human rights are one of the core principles in both guidelines and they draw upon the ‘Protect–Respect–Remedy’ framework of the UNGPs. The NVGs and NGRBC go beyond the UNGPs by requiring organizations not only to respect human rights, but also to promote them in their spheres of influence. Several factors, however, derailed the implementation of this progressive policy shift. This article explores the challenges in implementation and calls for the multiple actors involved to work together and shape a collaborative action plan for effective implementation of the NGRBC in the next decade. The authors reiterate the need for alternative lenses to frame the responsible business agenda within developing countries through positive obligations.
How readable and reliable is online patient information on chronic rhinosinusitis?
Authors: Habeeb A 
Published: June 2021

AbstractObjectiveThis study aimed to assess the quality and readability of websites on chronic rhinosinusitis.MethodsA total of 180 results from 3 different search engines regarding ‘chronic rhinosinusitis’, ‘sinusitis’ and ‘sinus infections’ were analysed for readability using the Flesch–Kincaid Grade Level, Flesch Reading Ease Score and Gunning Fog Index. The Discern tool was used to approximate information quality.ResultsFrom 180 total searches, 69 unique websites were identified. These had an average Flesch–Kincaid Grade Level of 9.75 (95 per cent confidence interval = 9.12–10.4), a Flesch Reading Ease Score of 45.0 (41.0–49.0) and a Gunning Fog Index of 13.7 (12.9–14.4), which equates to the average reading level of a college or university student. Discern scores were variable but consistently showed good-quality information.ConclusionChronic rhinosinusitis information is of a high quality but is for a reading level higher than that of the average adult. Standardising patient information should ensure adequate comprehension and improve patient compliance.
Women and estate management in the early eighteenth century: Barbara Savile at Rufford Abbey, Nottinghamshire (1700–34)
Authors: Law Sarah , Seymour Susanne , Watkins Charles 
Published: June 2021

AbstractThere is a rich and increasing body of research pointing to the significant role that elite women played in property management during the eighteenth century. In this article we examine the contribution of an elite widow, Barbara Savile, to the management of her son Sir George Savile’s extensive landholdings in Nottinghamshire and Yorkshire from 1700 until her death in 1734. We establish that Barbara Savile had a deep understanding of estate business and was a shrewd judge of character, expertise on which both Sir George and his stewards relied. She scrutinised account books, commissioned surveys for rental reassessment, was instrumental in the negotiation of wood contracts and was closely involved in the practical management of many aspects of tree and woodland management.
Lower White Matter Volume and Worse Executive Functioning Reflected in Higher Levels of Plasma GFAP among Older Adults with and Without Cognitive Impairment
Authors: Asken Breton M. , VandeVrede Lawren , Rojas Julio C. , Fonseca Corrina , Staffaroni Adam M. , Elahi Fanny M. , Lindbergh Cutter A. , Apple Alexandra C. , You Michelle , Weiner-Light Sophia , Brathaban Nivetha , Fernandes Nicole , Boxer Adam L. , Miller Bruce L. , Rosen Howie J. , Kramer Joel H. , Casaletto Kaitlin B. 
Published: June 2021

AbstractObjective:There are minimal data directly comparing plasma neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) in aging and neurodegenerative disease research. We evaluated associations of plasma NfL and plasma GFAP with brain volume and cognition in two independent cohorts of older adults diagnosed as clinically normal (CN), mild cognitive impairment (MCI), or Alzheimer’s dementia.Methods:We studied 121 total participants (Cohort 1: n = 50, age 71.6 ± 6.9 years, 78% CN, 22% MCI; Cohort 2: n = 71, age 72.2 ± 9.2 years, 45% CN, 25% MCI, 30% dementia). Gray and white matter volumes were obtained for total brain and broad subregions of interest (ROIs). Neuropsychological testing evaluated memory, executive functioning, language, and visuospatial abilities. Plasma samples were analyzed in duplicate for NfL and GFAP using single molecule array assays (Quanterix Simoa). Linear regression models with structural MRI and cognitive outcomes included plasma NfL and GFAP simultaneously along with relevant covariates.Results:Higher plasma GFAP was associated with lower white matter volume in both cohorts for temporal (Cohort 1: β = −0.33, p = .002; Cohort 2: β = −0.36, p = .03) and parietal ROIs (Cohort 1: β = −0.31, p = .01; Cohort 2: β = −0.35, p = .04). No consistent findings emerged for gray matter volumes. Higher plasma GFAP was associated with lower executive function scores (Cohort 1: β = −0.38, p = .01; Cohort 2: β = −0.36, p = .007). Plasma NfL was not associated with gray or white matter volumes, or cognition after adjusting for plasma GFAP.Conclusions:Plasma GFAP may be more sensitive to white matter and cognitive changes than plasma NfL. Biomarkers reflecting astroglial pathophysiology may capture complex dynamics of aging and neurodegenerative disease.
Death anxiety in patients with primary brain tumor: Measurement, prevalence, and determinants
Authors: Loughan Ashlee R. , Husain Mariya , Ravyts Scott G. , Willis Kelcie D. , Braun Sarah Ellen , Brechbiel Julia K. , Aslanzadeh Farah J. , Rodin Gary , Svikis Dace S. , Thacker Leroy 
Published: June 2021

AbstractObjectiveThis study investigated death anxiety in patients with primary brain tumor (PBT). We examined the psychometric properties of two validated death anxiety measures and determined the prevalence and possible determinants of death anxiety in this often-overlooked population.MethodsTwo cross-sectional studies in neuro-oncology were conducted. In Study 1, 81 patients with PBT completed psychological questionnaires, including the Templer Death Anxiety Scale (DAS). In Study 2, 109 patients with PBT completed similar questionnaires, including the Death and Dying Distress Scale (DADDS). Medical and disease-specific variables were collected across participants in both studies. Psychometric properties, including construct validity, internal consistency, and concurrent validity, were investigated. Levels of distress were analyzed using frequencies, and determinants of death anxiety were identified using logistic regression.ResultsThe DADDS was more psychometrically sound than the DAS in patients with PBT. Overall, 66% of PBT patients endorsed at least one symptom of distress about death and dying, with 48% experiencing moderate-severe death anxiety. Generalized anxiety symptoms and the fear of recurrence significantly predicted death anxiety.Significance of resultsThe DADDS is a more appropriate instrument than the DAS to assess death anxiety in neuro-oncology. The proportion of patients with PBT who experience death anxiety appears to be higher than in other advanced cancer populations. Death anxiety is a highly distressing symptom, especially when coupled with generalized anxiety and fears of disease progression, which appears to be the case in patients with PBT. Our findings call for routine monitoring and the treatment of death anxiety in neuro-oncology.
An Electron Density Model of the D‐ and E‐Region Ionosphere for Transionospheric VLF Propagation
Authors: Xu Wei , Marshall Robert A. , Bortnik Jacob , Bonnell John W. 
Published: June 2021

AbstractTerrestrial Very‐Low‐Frequency (VLF) energy from both lightning discharges and radio transmitters has a role in affecting the energetic electrons in the Van Allen radiation belts, but quantification of these effects is particularly difficult, largely due to the collisional damping experienced in the highly variable electron density in the D‐ and E‐region ionosphere. The Faraday International Reference Ionosphere (FIRI) model was specifically developed by combining lower‐ionosphere chemistry modeling with in situ rocket measurements, and represents to date the most reliable source of electron density profiles for the lower ionosphere. As a full‐resolution empirical model, FIRI is not well suited to D‐ and E‐region ionosphere inversion, and its applicability in transionospheric VLF simulation and in remote sensing of the lower ionosphere is limited. Motivated by how subionospheric VLF remote sensing has been aided by the Wait and Spies (WS) profile (Wait & Spies, 1964), in this study, we parameterize the FIRI profiles and extend the WS profile to the E‐region ionosphere by introducing two new parameters: the knee altitude hk and the sharpness parameter for the E‐region ionosphere βE. Using this modified WS profile, we calculate the expected signals at different receiver locations from the NAA, NPM, and NWC transmitters under the full range of possible ionospheric conditions. We also describe and validate a method about how these results can be readily used to translate VLF measurements into estimates of the lower ionosphere electron density. Moreover, we use this method to evaluate the sensitivity of different ground receiver locations in lower‐ionosphere remote sensing.
Formation of Magnesium Carbonates on Earth and Implications for Mars
Authors: Scheller Eva L. , Swindle Carl , Grotzinger John , Barnhart Holly , Bhattacharjee Surjyendu , Ehlmann Bethany L. , Farley Ken , Fischer Woodward W. , Greenberger Rebecca , Ingalls Miquela , Martin Peter E. , Osorio‐Rodriguez Daniela , Smith Ben P. 
Published: June 2021

AbstractMagnesium carbonates have been identified within the landing site of the Perseverance rover mission. This study reviews terrestrial analog environments and textural, mineral assemblage, isotopic, and elemental analyses that have been applied to establish formation conditions of magnesium carbonates. Magnesium carbonates form in five distinct settings: ultramafic rock‐hosted veins, the matrix of carbonated peridotite, nodules in soil, alkaline lake, and playa deposits, and as diagenetic replacements within lime—and dolostones. Dominant textures include fine‐grained or microcrystalline veins, nodules, and crusts. Microbial influences on formation are recorded in thrombolites, stromatolites, crinkly, and pustular laminites, spheroids, and filamentous microstructures. Mineral assemblages, fluid inclusions, and carbon, oxygen, magnesium, and clumped isotopes of carbon and oxygen have been used to determine the sources of carbon, magnesium, and fluid for magnesium carbonates as well as their temperatures of formation. Isotopic signatures in ultramafic rock‐hosted magnesium carbonates reveal that they form by either low‐temperature meteoric water infiltration and alteration, hydrothermal alteration, or metamorphic processes. Isotopic compositions of lacustrine magnesium carbonate record precipitation from lake water, evaporation processes, and ambient formation temperatures. Assessment of these features with similar analytical techniques applied to returned Martian samples can establish whether carbonates on ancient Mars were formed at high or low temperature conditions in the surface or subsurface through abiotic or biotic processes. The timing of carbonate formation processes could be constrained by 147Sm‐143Nd isochron, U‐Pb concordia, 207Pb‐206Pb isochron radiometric dating as well as 3He, 21Ne, 22Ne, or 36Ar surface exposure dating of returned Martian magnesium carbonate samples.