bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coupled Neutronics–Mechanics Analysis Method for Evaluation of Reactivity Change Due to Core Distortion in Sodium Fast Reactor
Authors: Bodi Janos , Ponomarev Alexander , Mikityuk Konstantin 
Published: March 2021

Abstract
In this article, a reactor core mechanical analysis method is introduced to provide a tool to calculate the reactivity effect of the fuel subassembly displacement in the reactor core, which is an important problem for reactor types such as the sodium-cooled fast reactor. The presented method relies on the following two main steps: (1) Core deformation calculation through a computer-aided design-based finite element solver and (2) static neutronic simulation on the original undeformed and deformed core models with a Monte Carlo code to quantify the reactivity effect. The technique makes it possible to accurately simulate the deformed geometry of the reactor core and to use this deformed shape model directly in the neutronic analysis. This article includes the verification process which was conducted to compare the accuracy of the finite element solver to the theoretical solutions regarding the deformation of a hexagonal subassembly. Moreover, the neutronic calculation accuracy has been demonstrated. Following this, a validation work has been performed on the Phenix sodium-cooled fast reactor based on the data obtained from previous, end-of-life test, and experimental setup. This procedure proved the accuracy of the presented methodology for both the verification and the validation cases, giving the capability to assess the reactivity effect of a nonuniform core deformation in a sodium-cooled fast reactor.
Recent Developments in the Design of Vertical Borehole Ground Heat Exchangers for Cost Reduction and Thermal Energy Storage
Authors: Liu Xiaobing , Spitler Jeffrey D. , Qu Ming , Shi Liang 
Published: March 2021

AbstractGround source (geothermal) heat pumps (GSHPs) can meet the thermal demands of buildings in an energy-efficient manner. The current high installation costs and long payback period limit the attractiveness of GSHP installation in the United States. Vertical borehole ground heat exchangers (VBGHEs), which are commonly used in GSHP systems, contribute most to the cost premium of GSHPs. Reducing the cost of VBGHEs could help increase market penetration of GSHP systems. This paper reviews recent developments for VBGHEs, including improvements in borehole heat transfer and borehole field layout, integration with thermal energy storage, and new design tools. Improvements in the borehole design and materials are more likely to be justified when the ground has high thermal conductivity. Integrating thermal energy storage can provide additional value to the GSHP system, especially when flexible electric demand at buildings becomes more valuable. Advanced design tools for VBGHEs that account for the thermal response of irregularly shaped borehole fields and that are more closely integrated with whole-building energy simulation programs may facilitate more innovations and optimization of GSHP system designs.
Numerical Investigation on Motion Responses of a Floating Hemisphere Over a Sloping Bottom
Authors: Liu Xiaolei , Wang Yiting , Wang Xuefeng , Wang Lei , Miao Quanming 
Published: March 2021

Abstract
In the last several decades, some numerical approaches have been proposed to deal with three-dimensional wave-body interaction problems in sloping bottom environment. Most of them either adopt the finite depth Green function or add numerical damping terms into the free surface condition to treat far field radiation condition, which certainly give rise to numerical errors. The hybrid model (Belibassakis, “A Boundary Element Method for the Hydrodynamic Analysis of Floating Bodies in Variable Bathymetry Regions,” Eng. Anal. Boundary Elements 32, pp. 796–810) adopting the consistent coupled-mode system for incident wave propagation problem combining with the three-dimensional bottom-dependent Green function to treat the diffraction and radiation problem is a complete formulation, as the latter function appropriately characterize the far field radiation wave pattern over a smoothly sloping bottom. However, this model has not been validated after its publication. In this connection, comparisons with computational fluid dynamic (CFD) results are presented to verify its accuracy. Application of this hybrid model is also performed to investigate the effects on the floating hemisphere by the sloping bottom.
Tilting Pad Bearing Pivot Friction and Design Effects on Thermal Bow-Induced Rotor Vibration
Authors: Shin Dongil , Palazzolo Alan B. 
Published: March 2021

Abstract
The Morton effect (ME) is a thermally induced vibration problem observed in a rotor supported by hydrodynamic bearings. The journal’s synchronous orbiting induces nonuniform viscous heating on its circumference, and the ensuing thermal bow often causes unacceptable vibration levels in the rotor. This paper investigates the influence of the tilting pad journal bearing (TPJB)’s pivot design on the severity and instability speed range of ME vibration. Simulations are conducted with two different types of pivots: cylindrical (CYL) and spherical (SPH), which produce different pad degrees-of-freedom and nonlinear pivot stiffness due to their geometries. The friction between pad and pivot, which only exists with the spherical pivot, is modeled, and its impact on the ME is evaluated. The example rotor model, as obtained from the literature, is single overhung, with experimentally measured excessive vibration and large journal temperature differentials, near 8000 rpm. The bearing and journal are modeled with three-dimensional (3D) finite elements, and the shaft with flexible beam elements for ME simulation. Nonlinear transient simulations are carried out for a wide operating speed range with varying pivot design parameters. Simulation results indicate that the predicted ME instability is sensitive to the pivot shape, pivot flexibility, and pad-pivot friction.
Body Composition, Energy Availability, Training, and Menstrual Status in Female Runners
Authors: Ihalainen Johanna K. , Kettunen Oona , McGawley Kerry , Solli Guro Strøm , Hackney Anthony C. , Mero Antti A. , Kyröläinen Heikki 
Published: March 2021

Purpose: To determine body composition, energy availability, training load, and menstrual status in young elite endurance running athletes (ATH) over 1 year, and in a secondary analysis, to investigate how these factors differ between nonrunning controls (CON), and amenorrheic (AME) and eumenorrheic (EUM) ATH. Correlations to injury, illness, and performance were also examined. Methods: Altogether 13 ATH and 8 CON completed the Low Energy Availability in Females Questionnaire. Anthropometric, energy intake, and peak oxygen uptake assessments were made at 4 time points throughout the year: at baseline post competition season, post general preparation, post specific preparation, and post competition season the following year. Logs of physical activity, menstrual cycle, illness, and injury were kept by all participants. Performance was defined using the highest International Association of Athletics Federations points prior to and after the study. Results: ATH had significantly lower body mass (P < .008), fat percentage (P < .001), and body mass index (P < .027) compared with CON, while energy availability did not differ between ATH and CON. The Low Energy Availability in Females Questionnaire score was higher in ATH than in CON (P < .028), and 8 ATH (vs zero CON) were AME. The AME had significantly more injury days (P < .041) and ran less (P < .046) than EUM, while total annual running distance was positively related to changes in performance in ATH (r < .62, P < .043, n < 11). Conclusions: More than half of this group of runners was AME, and they were injured more and ran less than their EUM counterparts. Furthermore, only the EUM runners increased their performance over the course of the year.
Vertical Ground Reaction Force Estimation From Benchmark Nonstationary Kinematic Data
Authors: Davis Daniel J. , Challis John H. 
Published: March 2021

Time-differentiating kinematic signals from optical motion capture amplifies the inherent noise content of those signals. Commonly, biomechanists address this problem by applying a Butterworth filter with the same cutoff frequency to all noisy displacement signals prior to differentiation. Nonstationary signals, those with time-varying frequency content, are widespread in biomechanics (eg, those containing an impact) and may necessitate a different filtering approach. A recently introduced signal filtering approach wherein signals are divided into sections based on their energy content and then Butterworth filtered with section-specific cutoff frequencies improved second derivative estimates in a nonstationary kinematic signal. Utilizing this signal-section filtering approach for estimating running vertical ground reaction forces saw more of the signal’s high-frequency content surrounding heel strike maintained without allowing inappropriate amounts of noise contamination in the remainder of the signal. Thus, this signal-section filtering approach resulted in superior estimates of vertical ground reaction forces compared with approaches that either used the same filter cutoff frequency across the entirety of each signal or across the entirety of all signals. Filtering kinematic signals using this signal-section filtering approach is useful in processing data from tasks containing an impact when accurate signal second derivative estimation is of interest.
Changes in Intermuscular Coherence as a Function of Age and Phase of Speech Production During an Overt Reading Task
Authors: Reed Alesha , Cummine Jacqueline , Bhat Neesha , Jhala Shivraj , Bakhtiari Reyhaneh , Boliek Carol A. 
Published: March 2021

Purpose: The authors evaluated changes in intermuscular coherence (IMC) of orofacial and speech breathing muscles across phase of speech production in healthy younger and older adults. Method: Sixty adults (30 younger = M: 26.97 year; 30 older = M: 66.37 year) read aloud a list of 40 words. IMC was evaluated across phase: preparation (300 ms before speech onset), initiation (300 ms after onset), and total execution (entire word). Results: Orofacial IMC was lowest in the initiation, higher in preparation, and highest for the total execution phase. Chest wall IMC was lowest for the preparation and initiation and highest for the total execution phase. Despite age-related differences in accuracy, neuromuscular modulation for phase was similar between groups. Conclusion: These results expand our knowledge of speech motor control by demonstrating that IMC is sensitive to phase of speech planning and production.
Randomised trial of epinephrine dose and flush volume in term newborn lambs
Authors: Sankaran Deepika , Chandrasekharan Praveen K , Gugino Sylvia F , Koenigsknecht Carmon , Helman Justin , Nair Jayasree , Mathew Bobby , Rawat Munmun , Vali Payam , Nielsen Lori , Tancredi Daniel J , Lakshminrusimha Satyan 
Published: March 2021

ObjectivesNeonatal resuscitation guidelines recommend 0.5–1 mL saline flush following 0.01–0.03 mg/kg of epinephrine via low umbilical venous catheter for persistent bradycardia despite effective positive pressure ventilation (PPV) and chest compressions (CC). We evaluated the effects of 1 mL vs 3 mL/kg flush volumes and 0.01 vs 0.03 mg/kg doses on return of spontaneous circulation (ROSC) and epinephrine pharmacokinetics in lambs with cardiac arrest.DesignForty term lambs in cardiac arrest were randomised to receive 0.01 or 0.03 mg/kg epinephrine followed by 1 mL or 3 mL/kg flush after effective PPV and CC. Epinephrine (with 1 mL flush) was repeated every 3 min until ROSC or until 20 min. Haemodynamics, blood gases and plasma epinephrine concentrations were monitored.ResultsTen lambs had ROSC before epinephrine administration and 2 died during instrumentation. Among 28 lambs that received epinephrine, 2/6 in 0.01 mg/kg-1 mL flush, 3/6 in 0.01 mg/kg-3 mL/kg flush, 5/7 in 0.03 mg/kg-1 mL flush and 9/9 in 0.03 mg/kg-3 mL/kg flush achieved ROSC (p=0.02). ROSC was five times faster with 0.03 mg/kg epinephrine compared with 0.01 mg/kg (adjusted HR (95% CI) 5.08 (1.7 to 15.25)) and three times faster with 3 mL/kg flush compared with 1 mL flush (3.5 (1.27 to 9.71)). Plasma epinephrine concentrations were higher with 0.01 mg/kg-3 mL/kg flush (adjusted geometric mean ratio 6.0 (1.4 to 25.7)), 0.03 mg/kg-1 mL flush (11.3 (2.1 to 60.3)) and 0.03 mg/kg-3 mL/kg flush (11.0 (2.2 to 55.3)) compared with 0.01 mg/kg-1 mL flush.Conclusions0.03 mg/kg epinephrine dose with 3 mL/kg flush volume is associated with the highest ROSC rate, increases peak plasma epinephrine concentrations and hastens time to ROSC. Clinical trials evaluating optimal epinephrine dose and flush volume are warranted.
MALT lymphoma and eosinophilic oesophagitis: incidental finding— review of possible factors influencing the aetiopathogenesis of eosinophilic oesophagitis
Authors: Fernandez Manso Beatriz , Barrio Torres Josefa , Martinez Escribano Beatriz , Perez Fernandez Cristina 
Published: March 2021

An 11-year-old boy with a history of atopy and allergic rhinitis under treatment with sublingual immunotherapy was referred following several episodes of food impaction. Diagnosis of eosinophilic oesophagitis, chronic gastritis and gastric mucosa-associated lymphoid tissue (MALT) lymphoma associated toHelicobacter pyloriwere confirmed. Results of the extension study were negative and the lymphoma was resolved with eradicating treatment forH. pylori. No improvement was observed in the oesophagitis after the withdrawal of immunotherapy and treatment with high proton pump inhibitor doses or following the omission of several foods to which subclinical sensitisation was confirmed. Oesophagitis was finally resolved by removing cow's milk protein. After 10 years, neither eosinophilic oesophagitis nor MALT lymphoma was observed.Gastric MALT lymphoma associated toH. pyloriis a rare disorder in children. Although coexistingH. pyloriinfection is common in patients with eosinophilic oesophagitis, the association of gastric MALT lymphoma with eosinophilic oesophagitis has not been reported before.
Real-world experience of using ciclosporin-A 0.1% in the management of ocular surface inflammatory diseases
Authors: Deshmukh Rashmi , Ting Darren Shu Jeng , Elsahn Ahmad , Mohammed Imran , Said Dalia G , Dua Harminder Singh 
Published: March 2021

PurposeTo report the real-world experience of using topical ciclosporin, Ikervis, in the management of ocular surface inflammatory diseases (OSIDs).MethodsThis was a retrospective study of patients treated with Ikervis for OSIDs at the Queen’s Medical Centre, Nottingham, between 2016 and 2019. Relevant data, including demographics, indications, clinical parameters, outcomes and adverse events, were collected and analysed for patients who had completed at least 6 months follow-up. For analytic purpose, clinical outcome was categorised as ‘successful’ (resolved or stable disease), ‘active disease’ and ‘drug intolerance’.Results463 patients were included; mean age was 51.1±21.6 years, with a 59.0% female predominance. Mean follow-up was 14.6±9.2 months. The most common diagnosis was dry eye disease (DED; 322, 69.5%), followed by allergic eye disease (AED; 53, 11.4%) and ocular mucous membrane pemphigoid/Steven-Johnson syndrome (OMMP/SJS; 38, 8.2%). Successful treatment was achieved in 343 (74.1%) patients, with 44 (9.5%) requiring additional treatment and 76 (16.4%) reporting drug intolerance. The efficacy of Ikervis was highest in DED (264, 82.0%), followed by OMMP/SJS (25, 65.8%) and post-keratoplasty (7, 50.0%; p<0.001). Logistic regression analysis demonstrated age <70 years (p=0.007), AED (p=0.002) and OMMP/SJS (p=0.001) as significant predictive factors for Ikervis intolerance. AED and post-keratoplasty were 8.16 times (95% CI, 2.78 to 23.99) and 13.98 times (95% CI, 4.22 to 46.28), respectively, more likely to require additional treatment compared with DED.ConclusionsIkervis is a useful steroid-sparing topical treatment for managing OSIDs in the real-world setting. Preparations with improved tolerability are needed to benefit a larger number of patients.
Oxidized LDL, insulin sensitivity and beta-cell function in newborns
Authors: Fang Fang , Nuyt Anne Monique , Garofalo Carole , Zhang Jun , Julien Pierre , Fraser William , Levy Emile , Luo Zhong-Cheng 
Published: March 2021

IntroductionOxidized low-density lipoprotein (OxLDL), a biomarker of oxidative stress, itself possesses proatherogenic and proinflammatory effects. Elevated circulating OxLDL levels have been consistently associated with insulin resistance and diabetes in adults. We sought to assess whether OxLDL may be associated with insulin sensitivity and beta-cell function in early life.Research design and methodsIn a birth cohort study, we assessed cord plasma OxLDL concentration and OxLDL to total LDL ratio in relation to glucose to insulin ratio (an indicator of fetal insulin sensitivity), proinsulin to insulin ratio (an indicator of fetal beta-cell function), and leptin and adiponectin concentrations in 248 singleton newborns.ResultsCord plasma OxLDL concentration was positively correlated with glucose to insulin ratio (r=0.24, p<0.001) and proinsulin to insulin ratio (r=0.20, p<0.001) and was not correlated with leptin or adiponectin. Adjusting for maternal and neonatal characteristics, each log unit increase in cord plasma OxLDL concentration was associated with a 25.8% (95% CI 12.8% to 40.3%) increase in glucose to insulin ratio and a 19.0% (95% CI 6.8% to 32.9%) increase in proinsulin to insulin ratio, respectively. Similar associations were observed for cord plasma OxLDL to LDL ratio in relation to cord plasma glucose to insulin ratio and proinsulin to insulin ratio.ConclusionsHigher OxLDL levels were associated with lower fetal beta-cell function (higher proinsulin to insulin ratio) but higher insulin sensitivity (higher glucose to insulin ratio). The study is the first to demonstrate that OxLDL may affect glucose metabolic health in early life in humans.
Change in time spent visiting and experiences of green space following restrictions on movement during the COVID-19 pandemic: a nationally representative cross-sectional study of UK adults
Authors: Burnett Hannah , Olsen Jonathan R , Nicholls Natalie , Mitchell Richard 
Published: March 2021

ObjectivesGreen space positively influences health and well-being; however, inequalities in use of green space are prevalent. Movement restrictions enforced due to the COVID-19 pandemic could have exacerbated existing inequalities regarding who visits green space. Therefore, this study aimed to explore how movement restrictions have changed the time spent visiting green space and experience of green space in the United Kingdom (UK) and how these differed by individual-level demographic characteristics.Design and outcome measuresA nationally representative cross-sectional survey administered through YouGov between 30 April and 1 May 2020. Data were collected on the time spent visiting green space and change in the experience of green space, including missing social interaction, increased physical activity and feeling greater mental health benefits in green space. Demographic information was collected on sex, age, ethnicity, social grade and dog ownership. Associations between specific outcome variables and predictors were assessed using logistic regression.SettingUK, with population weights applied.Participants2252 adults aged 18 years and over.ResultsOverall, 63% of respondents reported a decrease in time spent visiting green space following movement restrictions. Lower social grade respondents were less likely to visit green space before and after restrictions were enforced (OR: 0.35 (95% CI 0.24 to 0.51); OR: 0.77 (95% CI 0.63 to 0.95)). Female respondents were more likely than male respondents to agree that green space benefited their mental health more following restrictions (PP: 0.70 vs 0.59). Older (65+ years) respondents were less likely than middle-aged (25–64 years) respondents to have visited green space following the restrictions (OR: 0.79 (95% CI 0.63 to 0.98)).ConclusionsInequalities in green space use were sustained, and possibly exacerbated, during movement restrictions. Our findings emphasise the importance of green spaces remaining open globally in any future ‘lockdowns’/pandemics. Further investigation is required to determine how visit patterns and experiences change through the different stages of the COVID-19 pandemic in the UK.
Suicide as an incident of severe patient harm: a retrospective cohort study of investigations after suicide in Swedish healthcare in a 13-year perspective
Authors: Fröding Elin , Gäre Boel Andersson , Westrin Åsa , Ros Axel 
Published: March 2021

ObjectivesTo explore how mandatory reporting to the supervisory authority of suicides among recipients of healthcare services has influenced associated investigations conducted by the healthcare services, the lessons obtained and whether any suicide-prevention-related improvements in terms of patient safety had followed.Design and settingsRetrospective study of reports from Swedish primary and secondary healthcare to the supervisory authority after suicide.ParticipantsCohort 1: the cases reported to the supervisory authority in 2006, from the time the reporting of suicides became mandatory, to 2007 (n=279). Cohort 2: the cases reported in 2015, a period of well-established reporting (n=436). Cohort 3: the cases reported from September 2017, which was the time the law regarding reporting was removed, to November 2019 (n=316).Primary and secondary outcome measuresDemographic data and received treatment in the months preceding suicide were registered. Reported deficiencies in healthcare and actions were categorised by using a coding scheme, analysed per individual and aggregated per cohort. Separate notes were made when a deficiency or action was related to a healthcare-service routine.ResultsThe investigations largely adopted a microsystem perspective, focusing on final patient contact, throughout the overall study period. Updating existing or developing new routines as well as educational actions were increasingly proposed over time, while sharing conclusions across departments rarely was recommended.ConclusionsThe mandatory reporting of suicides as potential cases of patient harm was shown to be restricted to information transfer between healthcare providers and the supervisory authority, rather than fostering participative improvement of patient safety for suicidal patients.The similarity in outcomes across the cohorts, regardless of changes in legislation, suggests that the investigations were adapted to suit the structure of the authority’s reports rather than the specific incident type, and that no new service improvements or lessons are being identified.