bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of IgG4-related Disease Complicated With Allergic Rhinitis or Chronic Rhinosinusitis: A Large Cohort Study in China
Authors: Liu Yanying , Shi Qianyu , Ning Xiaoran , Li Huijuan , Ma Xiangbo , Wang Kunkun , Bian Wenjie , Zhang Yuxin , Li Zhanguo 
Published: November 2021

Abstract
ObjectivePatients of IgG4-related disease (IgG4-RD) often present nasal symptoms that could be diagnosed as allergic rhinitis (AR) or chronic rhinosinusitis (CRS). In this study, demographic, clinical and laboratory characteristics of IgG4-RD patients complicated with AR/CRS were investigated.MethodsWe retrospectively analyzed 756 IgG4-RD patients who were recruited in five medical centers from 2009 to 2021. We divided 756 IgG4-RD patients into 2 groups: the case group included IgG4-RD patients complicated with AR/CRS, and the control group included IgG4-RD patients without AR/CRS. Results411 patients were diagnosed as AR/CRS among the 756 patients. Patients in the case group showed longer disease duration and interval between symptom onset and diagnosis. Multiple organs involvement(≥3) and allergic disease were more common in the case group. The most frequently involved organs in the case group were lung, salivary gland and lacrimal gland. Patients in the case group had a higher level of serum IgG4, IgE and ESR. High IgE level and complication of allergic disease were risk factors for patients in the case group. In the case group, most patients had nasal manifestations before the diagnosis of IgG4-RD. The median time interval from nasal symptoms appearance to IgG4-RD diagnosis was -120 and -90 months for patients complicated with AR and CRS, respectively.ConclusionThis study revealed the clinical characteristics of IgG4-RD patients complicated with AR/CRS. Our findings may be conducive to determine a new clinical entity of IgG4-RD and suggest underlying association of pathogenesis of IgG4-RD and AR/CRS.
Simulation of Emergency Evacuation from Construction Site of Prefabricated Buildings
Authors: XIAO Mufeng , ZHOU Xihua , PAN Xinxin , WANG Yanan , LI Xianlin , SUN Yashengnan , WANG Yumeng , WANG Jue 
Published: November 2021

Abstract
To ensure the safe construction of prefabricated buildings and improve the efficiency of the safe evacuation of construction personnel after a fire caused by improper operation during construction, this study used the PyroSim software to numerically simulate a fire situation based on the size and volume of a prefabricated building construction site. The variation rules of smoke visibility, CO concentration, and ambient temperature in the construction site of prefabricated buildings were analyzed and the available safe evacuation time was determined. Moreover, the Pathfinder software was used for simulation in combination with the physical attributes of personnel, evacuation speed, and personnel proportions. The time required for safe evacuation was determined and the factors influencing the evacuation time, such as the quantity and location of stacked prefabricated components, machinery, and appliances, and the number of on-site construction personnel, were analyzed. The results reveal that the original layout of the prefabricated building construction site cannot facilitate the safe evacuation of all construction personnel. The bottleneck area for the evacuation of construction personnel is the indoor corridor and evacuation stairway. The quantity and location of stacked items at the construction site greatly influence the evacuation time. When the number of construction personnel on each floor reaches a certain value, restrictions should be imposed. The results obtained by this study can provide the theoretical basis for the rational planning of evacuation routes and construction site management.
Phylogenetic α- and β-Diversities Jointly Reveal Leaf-Litter Ant Community Assembly Mechanisms Along a Tropical Elevational Gradient
Authors: Pérez-Toledo Gibran Renoy , Villalobos Fabricio , Silva Rogerio R. , Moreno Claudia E. , Pie Marcio , Valenzuela-González Jorge. E. 
Published: November 2021

Abstract
Despite the long-standing interest in the organization of ant communities across elevational gradients, few studies have incorporated the evolutionary information to understand the historical processes that underlay such patterns. Through the evaluation of phylogenetic α and β-diversity, we analyzed the structure of leaf-litter ant communities along the Cofre de Perote mountain in Mexico and inferred its putative driving forces. Lowland and some highland sites showed phylogenetic clustering, whereas intermediate elevations and the highest site presented phylogenetic overdispersion. We infer that strong environmental constrains found at the bottom and the top elevations are favoring closely-related species to prevail at those elevations. Conversely, more benign conditions at intermediate elevations suggest interspecific interactions being more important in these environments. Total phylogenetic dissimilarity was driven by the turnover component, indicating that the turnover of ant species along the mountain is actually shifts of lineages adapted to particular locations resembling their ancestral niche. The greater phylogenetic dissimilarity between communities was related to greater temperature distances probably due to narrow thermal tolerances inherit to several ant lineages that evolved in more stable conditions. Our results suggest that the interplay between environmental filtering, interspecific competition and habitat specialization plays an important role in the assembly of leaf-litter ant communities along elevational gradients.
Epigenomic Insight of Lingonberry: Health Promoting Trait Under Micropropagation
Authors: Sikdar Arindam , Sharma Umanath , Barua Rajesh , Igamberdiev Abir U. , Debnath Samir C. 
Published: November 2021

Abstract
Epigenetic variation plays a role in developmental gene regulation and responses to the environment. An efficient interaction of zeatin induced cytosine methylation and secondary compounds has been displayed for the first time in tissue-culture shoots of lingonberry (Vaccinium vitis-idaea) in vitro, in vivo and its cutting-cultivar Erntedank. Through MSAP assay, we observed highest methylated sites in leaf regenerants (LC1) from all primer combinations (108 bands), with their highest variation in secondary metabolites. We measured that four tissue-culture plants showed higher methylation bands than cutting propagated donor plants (ED) which exhibited 79 bands of methylation, which is comparatively low. On the other hand, we observed the highest total phenolic content in node culture-derived greenhouse grown plants, NC3 but leaf culture-derived greenhouse grown plants, LC1 represented low phenolic content. Our study showed more methylation in micropropagated plants (NC1, NC2, NC3, LC1) than those derived from cutting propagated ED plants, where methylation was not present. On the contrary, we observed higher secondary metabolites in ED plants but comparatively less in micropropagated shoots (NC1, NC2) and plants (NC3, LC1). Our study displayed that higher methylation sites observed in micropropagated plants possessed less amount of secondary metabolites.
Delirium During COVID-19 Pandemic: Were We Over-Reporting an Overlooked Syndrome?
Authors: Alencar Júlio César Garcia , Carvalho Flávia Barreto Garcez , Veiga Alicia Duddy Müller , Stanzani Gabriela Souza , Maia Ian Ward Abdalla , Pera Isabella Hiray , Numakura Guilherme Tetsuo Yokoy , Santos Leticia Ruivo , Silva Thiago Junqueira Avelino , Souza Heraldo Possolo 
Published: November 2021

Abstract
Background
Delirium is an overlooked syndrome in Emergency Departments (ED) around the world. Previous studies demonstrated high incidence of Delirium in elderly patients with COVID-19, however, these studies did not compare Delirium incidences in patients admitted for SARS-CoV-2 infection or sepsis for other etiologies.
Methods
This is an observational study that analyzed elderly patients (> 65 years) from two cohort studies that recruited patients in the ED at Hospital Clínicas da Faculdade de Medicina da Universidade de São Paulo, an urban, academic department in São Paulo, Brazil. The first cohort studied patients with sepsis and was conducted between September 30, 2019, and March 17, 2020. The second cohort studied COVID-19 patients between April 8, 2021, and May 28, 2021. Our primary outcome was incidence of delirium at admission in ED, which we defined using the Confusion Assessment Method (CAM). Additional study information was collected from medical records.
Results
We included 141 patients in our final analysis, with a median age of 72 (IQR 68-79) years and a predominance of the male sex (58%). We identified delirium at admission in 31 participants (22%), 20 in septic group and 11 in COVID-19 group (p = 0.70).
Conclusion
This present study does not support that elderly patients with COVID-19 have higher risk for Delirium at admission in Emergency Department when compared to patients hospitalized with sepsis for other etiologies. In spite of sepsis for COVID-19 have had more than 28% mortality, COVID-19 was not associated with higher mortality in elderly than sepsis for other etiologies.
Gliosarcoma with Osteosarcomatous Component: A Case Report and Short Review Illustration
Authors: Chen Yanming , Zhou Sujuan , Zhou Xuelan , Dai Xiaoxiao , Wang Liping , Chen Ping , Zhao Shengbin , Shi Changjun , Xiao Sheng , Dong Jun 
Published: November 2021

Abstract
Background: Gliosarcoma (GS) represents a rare variant of glioblastoma in the central nervous system, characterized by biphasic histopathological features of gliomatous and sarcomatous components. Here, we present an unusual case of GS, which also demonstrated osteosarcomatous component. Case presentations: The patient underwent gross total resection (GTR) of right temporal lobe lesion. Subsequently received external beam radiation therapy with 60 Gy and chemotherapy, postoperatively. The sarcomatous portion of the typical fibrosarcoma pattern mingled with areas of osteoid structure in this 65-year-old feminine case. The molecular pathological analysis demonstrated IDH1/2 wild-type and MGMT promoter island methylated phenotype. Target Enrichment Sequencing (TES) was performed on the gliomatous and sarcomatous components of the tumor tissues. TERT promoter, RB1, NF1, TP53 mutations and copy number variations (CNVs) on chromosome 7, 10q, 11q, 12, 13, 17 and 22 were observed in gliomatous and fibro-sarcomatous mixed tumor tissue; While we found TERT promoter, RB1, TP53 mutations and CNVs on chromosome 2q, 3q, 7, 8, 9, 10, 11, 12, 13, 15, 16, 17, 18, 19 and 22 in osteosarcomatous tumor tissue. Noteworthy, EGFR amplification was not observed in both gliomatous and sarcomatous tumor tissues. Conclusions: In conclusion, integrated with histopathology, molecular pathology, and genomic alteration analysis, we report a case of GS with an extremely rare histopathologic phenotype of osteosarcomatous differentiation, also suffered lung multi-metastases. Additionally, by reviewing the literature, our study of this unusual differentiation of GS into osteosarcoma provides novel insight into the natural history of GS.
Unity Yield of Deterministically Positioned Quantum Dot Single Photon Sources
Authors: Laferriere Patrick , Yeung Edith , Miron Isabelle , Northeast David , Haffouz Sofiane , Lapointe Jean , Korkusinski Marek , Poole Philip , Williams Robin , Dalacu Dan 
Published: November 2021

Abstract
We report on a platform for the production of single photon devices with a fabrication yield of 100%. The sources are based on InAsP quantum dots embedded within position-controlled bottom-up InP nanowires. Using optimized growth conditions, we produce large arrays of structures having highly uniform geometries. Collection efficiencies are as high as 83% and multiphoton emission probabilities as low as 0.6% with the distribution away from optimal values associated with the excitation of other charge complexes and re-excitation processes, respectively, inherent to the above-band excitation employed. Importantly, emission peak lines hapes have Lorentzian profiles indicating that linewidths are not limited by inhomogeneous broadening but rather pure dephasing, likely elastic carrier-phonon scattering due to a high phonon occupation. This work establishes nanowire-based devices as a viable route for the scalable fabrication of efficient single photon sources and provides a valuable resource for hybrid on-chip platforms currently being developed.
Dealing With Pluralism: Managerial Work of CEOs in Italian Public Healthcare Organizations
Authors: Lega Federico , Rotolo Andrea , Sartirana Marco 
Published: November 2021

Abstract
Background: Healthcare organizations are extremely complex, and the work of their CEOs is particularly demanding, especially in the public sector. However, we know little about how healthcare executives’ managerial work unfolds. Drawing from scholarship on pluralistic organizations and managerial work, we answer the questions: what is the content of managerial work of executives in public healthcare? How do CEOs deal with pressures from internal and external stakeholders while maintaining a strategic agenda?Methods: We adopted a mixed method with a survey to measure CEO behaviors, coding CEOs time for four weeks; a questionnaire to understand the strategic dimensions of interactions; interviews of senior CEOs.Results: CEOs in Italian public healthcare devote most of their time to interactions, by and large responding to pressures by internal stakeholders. Although half of this time is perceived as occupied in answering operational requests, this is necessary to nurture relations, create networks and develop alliances and consensus, which are functional in achieving CEOs’ strategic agenda.Conclusions: CEOs in public healthcare must deal with enormous contextual pressures and cannot manage the complexity but are called to manage within the complexity, fostering involvement in decision making, building networks, and establishing alliances. Amidst ambiguity and fragmentation, executives need to find solutions to perform their managerial work without being entrapped by stakeholders’ pressures, thanks to effective stakeholder management as well as delegation.Trial registration: The article does not report the results of a health care intervention on human participants, and material used in the research did not need ethical approval according to Italian law.
Gravel Parameterization Scheme and Verification Using BCC_CSM
Authors: xu yue , Lyu Shihua , Ma Yaomig , Zhang Shaobo , Ma Cuili , Liu Yigang 
Published: November 2021

Abstract
The soil in China contains an abundance of gravels, but it is poorly described in land surface models. To solve this problem, the Beijing Climate Center Atmosphere–Vegetation Interaction Model (BCC_AVIM), which is a land surface model with the gravel parameterization, is coupled to the Beijing Climate Center System Model (BCC_CSM). The simulation ability of BCC_CSM for China using the gravel parameterization is evaluated by comparing the simulation results using original and new schemes with the observed data. The results show that the annual average surface temperature simulated with the new scheme is more consistent with the observation in terms of the spatial distribution, and the simulation results in Southwest China, Northwest China and the Qinghai-Tibet Plateau are significantly improved, especially in summer. In the perspective of the area-averaged variables, the situation of more precipitation simulated using the original scheme is improved except for summer. The high-level and low-level wind fields simulated by BCC_CSM have a significant improvement in the Qinghai-Tibet Plateau. In general, this gravel parameterization is more suitable for areas with the high gravel content, and it improves the simulation performance of BCC_CSM in some areas of China.
Diversity of Endophytic Bacteria Associated with Different Cultivars of Medicinal Plant Arctium Lappa L. and Their Potential for Host Plant Growth Promoting
Authors: Liu Jia-Qi , Zhang Chun-Mei , Gong Yuan , Xu Ming-Jie , Xing Ke , Gao Jun , Li Cheng-Guo , Zhang Yu- Qin , Qin Sheng 
Published: November 2021

Abstract
Purpose

Arctium lappa L. is one of the medicinal and food homologous plants in China, which is rich in nutrients and medicinal ingredients. The use of plant growth promoting (PGP) endophytic bacteria is a useful alternative in agricultural production to reduce the use of chemical fertilizers. The aim of this study was to analysis the diversity of endophytic bacteria in different cultivars of A. lappa L. collected from two different geographical locations in China and evaluate PGP traits of the isolates and their potential PGP ability in greenhouse condition.
Methods

Endophytic bacterial community was investigated by culture-dependent and culture-independent methods. Isolates were screened and investigated for multiple PGP traits, and representative strains were inoculated host seedlings to evaluate the growth promoting effect.
Results

A total of 348 endophytic bacteria were obtained and they distributed into four phyla, 30 genera and 73 different species. In addition, high throughput sequencing revealed more abundant bacterial community, including 17 bacterial phyla, and 207 different known genera. A high proportion of PGP traits were detected, including production of indole acetic acid, siderophore, ammonia and phosphate solubilization. Four representative strains with multiple PGP traits of the most prevalent genera were further selected for host inoculation and growth promoting evaluation, and they significantly increase seedlings length, root length and fresh weight.
Conclusion

This study demonstrated that A. lappa L. harbors abundant endophytic bacteria, and plant genotype and geographical origin affect their composition. Moreover, some endophytic bacteria showed good potential for the development of microbial fertilizer in the future.
Reexamining Empathy in Autism: The Role of Empathic Disequilibrium in Autism and Autistic Traits
Authors: Shalev Ido , Warrier Varun , Greenberg David M , Smith Paula , Allison Carrie , Baron-Cohen Simon , Eran Alal , Uzefovsky Florina 
Published: November 2021

Abstract
Background: While many autistics report feelings of excessive empathy, their experience is not reflected by most of the current literature, which typically, but not always, suggests that autism is characterized by intact emotional empathy and reduced cognitive empathy. To try and bridge this gap in empirical findings and with respect to individuals' experiences, we examined a novel conceptualization of empathy termed empathic disequilibrium, i.e., the imbalance between emotional and cognitive empathy. Empathic disequilibrium was previously found to predict autistic traits in non-autistic population, suggesting it is an important empathy measure. Here, we aimed to extend the generalizability of empathic disequilibrium to the autistic population and to provide a better analytical approach to examine this construct.Methods: We analyzed self-reports of empathy and autistic traits in a large cohort (N = 4,914) of autistic and non-autistic individuals. We applied a polynomial regression with response surface analysis to examine empathic disequilibrium and total empathy as predictors of an autism diagnosis and autistic traits. Results: Total empathy and empathic disequilibrium each predicted autism. There was a higher probability for diagnosis in individuals with lower total empathy, but also in individuals with higher emotional relative to cognitive empathy. Linear and non-linear patterns linked empathy, empathic disequilibrium, and autistic traits and diagnosis, with empathic disequilibrium being more prominent in females. Conclusions: Empathic disequilibrium might allow for a more nuanced and sensitive understanding of empathy and its link with autism. This study provides empirical evidence that empathic disequilibrium is at least as informative as empathy for assessing autism, and offers a novel analytical approach for examining the role of empathy at the phenomenological level.
CC-Chemokine Ligand 18, CXC Motif Chemokine 13, and Osteopontin as Biomarkers of Silicosis and Asbestosis: A Case-Control Study
Authors: Wu Na , Xue Changjiang , Fan Yali , Ma Ruimin , Cai Dandan , Ye Qiao 
Published: November 2021

Abstract
Background

Silicosis and asbestosis are progressive pneumoconiosis characterized by interstitial fibrosis exposure to silica dust or asbestos fibres. This study aimed to explore the potential biomarkers for diagnosis of silicosis or asbestosis.
Methods

Plasma concentrations of CC-chemokine ligand 18 (CCL18), CXC motif chemokine 13 (CXCL13), osteopontin (OPN), periostin, and fibulin-3 were compared between silicosis, asbestosis, and healthy controls (HCs). The receiver operating characteristic (ROC) curve was used to monitor the diagnostic sensitivity, and their correlation to disease severity was examined.
Results

Plasma CCL18, CXCL13, and OPN concentrations in both patient groups were high. For silicosis patients, these plasma concentrations were significantly correlated with predicted forced vital capacity (FVC%) and lung diffusing capacity for carbon monoxide (DLCO SB%). The order of diagnostic accuracy was CCL18, OPN, and CXCL13 in silicosis or asbestosis. Combining CCL18, OPN, and CXCL13 can improve diagnostic accuracy.
Conclusions

CCL18, CXCL13, and OPN are available biomarkers for the diagnosis of silicosis and asbestosis.
Distribution of the Genus Ceratocystiopsis (Ascomycota, Ophiostomatales) on Conifers in Norway, With Description of Four New Species
Authors: Jankowiak Robert , Solheim Halvor , Bilański Piotr , Mukhopadhyay Jigeesha , Hausner Georg 
Published: November 2021

Abstract
The genus Ceartocystiopsis includes ascomycetes fungi belonging to the Ophiostomatales that are not well recognized in the world. Described species so far have been found mainly in association with bark beetles in the Northern Hemisphere. The aims of this study were therefore to survey of distribution of species of Ceratocystiopsis associated with bark beetles infesting Picea abies and Pinus sylvestris in Norway. Adults for 22 different bark beetle species were collected from 13 stands in Norway. During this study, we recovered 126 isolates showing affinities to Ceratocystiopsis representing six species, including two described and four undescribed taxa. The four undescribed taxa collected during this work were characterised based on their morphological characteristics and multi-gene phylogenies. Herein, we describe these new species as Ceratocystiopsis chalcographii sp. nov., Ceratocystiopsis debeeria sp. nov., Ceratocystiopsis norroenii sp. nov. and Ceratocystiopsis troendelagii sp. nov. Ceratocystiopsis norroenii and C. rollhanseniana were the most frequently isolated species although the latter species had a much wider vector range. This study expands our knowledge about the taxonomy and species diversity of Ceratocystiopsis and beetle-fungus relationships.