bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and Functional State of the Visual Analyzer after Surgery for the Epiretinal Membrane from the Standpoint of the Relevance of Postoperative Rehabilitation
Authors: Malyshev A. V. , Balayan A. S. , Pavlov A. I. , Ovechkin I. G. 
Published: April 2021

Purpose: to study the clinical and functional state of the visual analyzer of patients after surgery for the epiretinal membrane (ERM) from the standpoint of the relevance of postoperative rehabilitation.Patients and methods. There were 158 patients under observation (158 eyes, main group, MG), among whom 66 % were men, 34 % were women aged 45–74 years (the average age of patients was 62.4 ± 1.5 years) with a diagnosis of ERM. At the same time, the leading form of ERM was idiopathic (122 patients, 77.2 %). As a control group (CG), were examined 32 patients of equal age and gender, who did not have visual organ pathology. In order to remove ERM, all patients underwent subtotal posterior vitrectomy with intraoperative administration of antioxidants, in particular glutathione contained in a balanced salt solution “BSS-PLUS” (Bausch + Lomb, USA). A comprehensive examination of the clinical and functional state of the visual analyzer was performed one month after surgery.Results. The data obtained indicate that almost all the studied parameters revealed a significant deterioration in the MG compared to the CG with a fairly good anatomical effect (the thickness of the central retinal zone after the operation was 287.1 ± 11.6 μm). In particular, a decrease in the subjective indicator “Quality of life” (by 53.1 %), as well as a deterioration in the objective indicators of the critical frequency of flicker fusion, the magnitude of the electrical lability of the retina and the threshold of electrical sensitivity of the retina (by 36.2; 38.2 and 45, 5 % respectively).Conclusions. A fairly good anatomical effect of vitreoretinal surgical intervention for ERM is accompanied (one month after the operation) by a significant decrease in the functional state of the visual analyzer. In order to restore vision more quickly, it seems advisable to conduct early postoperative rehabilitation (based on the complex use of physiotherapeutic effects and combined drug therapy) aimed at correcting functional disorders of the retina, which will lead to a decrease in the severity of characteristic complaints and an increase in the “Quality of life” of the patient.
Make-Up Removers and Eye Surface
Authors: Trubilin V. N. , Poluninа E. G. , Chinenova K. V. , Kurenkov V. V. , Kapkova S. G. 
Published: April 2021

Purpose: to evaluate the influence on the state of the eye surface and the tear-producing system of decorative cosmetics and cosmetic products with different chemical bases for removing makeup.Patients and methods. The study included 45 (90 eyes) persons without clinical signs of an acute inflammatory process of the eye surface, they were prescribed the use of one of the Biore products: 15 people — makeup removal wipes, 15-micellar water, 15-makeup removal serum. The results of the objective (biomicroscopy, tests for lacrimal production) and subjective examinations are included in the questionnaires developed and standardized for this study (3 visits after the start of the use of cosmetics, 14, 30 days after the start of their use).Results. There were no significant differences (p > 0.5) between the groups that used makeup remover products on different bases — makeup remover serum, micellar water, makeup remover wipes — in all the patients included in the study. Patients with signs of a chronic inflammatory process on the eye surface and dry eye syndrome are less tolerant of makeup remover, which is manifested in a lower subjective assessment of these products after their use compared to patients without signs of an inflammatory process (p < 0.5). A correlation was determined at r = 0.3085, p = 0.0392 between the skin type and the Schirmer test parameters, exactly, the more oily the skin, the higher the Schirmer test parameters, it indicates a possible relationship between the skin type and the functional activity of the tear-forming glands, which indicates the need for further research in this area. The absence of a correlation (p > 0.5) between objective and subjective parameters that characterize the state of the eye surface and the tear-producing system, as well as the number of hours per day when decorative cosmetics are used, indicates that prolonged use of this type of exposure does not lead to the development of a pathological process on the eye surface.
Аutosomal Dominant Oculodental-Digital Dysplasia with Mutation in Gene GJA1 (Clinical Case)
Authors: Zolnikova I. V. , Kadyshev V. V. , Marakhonov A. V. , Kutsev S. I. , Zinchenko R. A. 
Published: April 2021

The purpose: to describe clinical cases of oculodental-digital dysplasia (ODDD, OMIM #164200) with mutation in GJA1 (OMIM 121014) with molecular genetic verification of the diagnosis.Methods. The article describes the clinical case of oculodental-digital dysplasia in a 51 years old patient. Patient underwent full ophthalmic examination including autorefractometry, visual acuity testing with full correction, tonometry, biomicroscopy, fundus examination and photo as well as kinetic perimetry, autofluorescence and optical coherence tomography (OCT) of macula and optic disk were performed. Electrophysiological examination included Visual Evoked Potentials (VEP) to flash and pattern stimulation, ISCEV standard electroretinograms (ERG) and macular ERG. For the verification of the diagnosis and pathologic gene molecular genetic examination was performed with family anamnesis previously attained.Results. The patient was complaining the deterioration of vision, hearing loss and the sense of smell. Visual deterioration was associated with nyctalopia. Natural history revealed glaucoma 2а which was diagnosed when he was 48 years old. Best corrected visual acuity was 1,0. Peripheral visual field defects were revealed bilaterally. High visual acuity correlated with normal foveal structure on OCTs the retinal nerve fiber layer (RNFL) was thinner than normal in temporal half; deep excavation was visualized in both eyes. Normal MERG and bilateral decrease of scotopic, maximal full-field ERG was recorded which correlated with nyctalopia, as well as subnormal photopic responses indicating cone system involvement. The genetics revealed characteristic features of the face: a small nose with hypoplasia of the wings of the nose, unfolded nostrils and a wide bridge of the nose (pseudohypertelorism). On right-wing the ear sink was detected 2 antitraguses. Changes fingers upper extremities — operated syndactyly IV and V on the background of brachydactyly of the fingers. On the legs on both sides — syndactyly III–IV. 10 years the sense of smell has been dereriorated. In the study of DNA in proband in direct Sanger sequencing of all exons 1–2 and regions of exon-intron compounds of gene GJA1, was found the pathogenic variant in second exon c.412G>A (p.Gly138Ser) in heterozygous state. Was established autosomal dominant type of disease.Conclusion. We are the first to describe rod-cone dystrophy in oculodental-digital dysplasia.
Doenças e situações de vulnerabilidade das mulheres no contexto rural: uma revisão integrativa
Authors: Richter Samanta Andresa , Gevehr Daniel Luciano 
Published: April 2021

Objetivo: identificar as doenças e situações de vulnerabilidade mais prevalentes, com maior impacto à saúde da mulher no contexto rural. Método: Trata-se de uma revisão integrativa, na qual foram selecionadas 32 publicações das plataformas SciELO, LILACS e PubMed, no período de maio a junho de 2018. Resultados e Discussão: dos artigos selecionados 71,86% são artigos estrangeiros. A maior parte dos artigos têm sua publicação concentrada nos anos de 2016, 2014 e 2015, somando 59,37%, mais da metade dos trabalhos selecionados. Conclusão: Embora, existam diferenças no contexto rural, muitas das doenças vivenciadas pelas mulheres do urbano também aparecem entre as rurais. Porém a acessibilidade e a baixa escolaridade são grande diferenciais entre as mulheres urbano/rural, o que reafirma a importância da elaboração de estratégias de melhoramento das condições de vida da mulher rural.
ANALISIS KEMAMPUAN LITERASI SAINS DITINJAU DARI KEBIASAAN MEMBACA, MOTIVASI BELAJAR DAN PRESTASI BELAJAR
Authors: Yanti Rosmalah , Prihatin Titi , Khumaedi Khumaedi 
Published: April 2021

<p class="IsiAbstrakIndo">Penelitian ini bertujuan untuk menganalisis (1) pengaruh langsung kebiasaan membaca terhadap motivasi belajar; (2) pengaruh langsung kebiasaan membaca terhadap prestasi belajar; (3) pengaruh langsung motivasi belajar terhadap prestasi belajar; (4) pengaruh langsung kebiasaan membaca terhadap kemampuan literasi sains; (5) pengaruh langsung motivasi belajar terhadap kemampuan literasi sains; (6) pengaruh langsung prestasi belajar terhadap kemampuan literasi sains; (7) pengaruh tidak langsung kebiasaan membaca terhadap prestasi belajar; (8) pengaruh tidak langsung kebiasaan membaca terhadap kemampuan literasi sains; dan (9) pengaruh tidak langsung motivasi belajar terhadap kemampuan literasi sains. Metode penelitian ini adalah <em>Ex Post Facto</em>. Sampel berjumlah 112 siswa kelas VII di Kabupaten Luwu. Pengambilan sampel menggunakan <em>cluster</em><em> random sampling</em>. Teknik analisis data menggunakan analisis jalur. Hasil penelitian adalah sebagai berikut 1) kebiasaan membaca berpengaruh secara langsung sebesar 0,16% terhadap motivasi belajar, 9,67% terhadap prestasi belajar, dan 3,6% terhadap kemampuan literasi sains; 2) motivasi belajar dapat memberikan pengaruh langsung sebesar 1,58% terhadap prestasi belajar, dan 3) prestasi belajar memberi pengaruh langsung terhadap kemampuan literasi sains sebesar 7,12%. Pengaruh tidak langsung kebiasaan membaca sebesar 10,17% terhadap prestasi belajar melalui motivasi belajar, serta berpengaruh terhadap kemampuan literasi sains melalui motivasi belajar sebesar 3,73%. Motivasi belajar tidak berpengaruh terhadap kemampuan literasi sains siswa. Kemampuan literasi sains siswa secara dominan dipengaruhi oleh kebiasaan membaca sehingga sebaiknya siswa dilatih dan dibiasakan mengerjakan soal-soal yang menguji dan dapat meningkatkan kemampuan literasi sains.</p>
Pseudotumors in Total Joint Arthroplasty
Authors: van der Merwe Johannes Michiel 
Published: April 2021

» The true incidence of pseudotumors in association with total joint arthroplasty is underestimated.» Pseudotumors occur with metal-on-metal, metal-on-polyethylene, and metal-on-ceramic articulations.» Metal ion levels should not be the only factor in decision-making regarding revision surgery.» Revision surgery is only indicated in symptomatic patients with clinical and radiographic findings and elevated metal ion levels.» Revision to a non-metal articulation is strongly suggested.
Surfing Injuries
Authors: Bickley Ryan J. , Belyea Christopher M. , Harpstrite J. Kimo , Min Kyong S 
Published: April 2021

» Surfing is safe: the risk of injury ranges from 0.26 to 0.90 injuries per surfer per year, 0.06 to 3.5 injuries per 1,000 days of surfing, and 1.1 to 13.0 injuries per 1,000 hours of surfing.» The most common acute surfing injuries are lacerations, contusions, and sprains; the head and the neck as well as the lower extremities are the locations that are affected most.» The most common mechanism of injury is striking a surfer’s own board or that of another surfer.» A pathology that is unique to surfers is surfer’s myelopathy; bites and/or stings by sea life and infections caused by marine life also occur in surfers.
STUDY OF NUTRITIONAL CONTENTS OF SEA URCHIN GONAD FROM DRINI BEACH, GUNUNG KIDUL, YOGYAKARTA
Authors: Pringgenies Delianis , Indrajati Richardus Mahatmada , Djunaedi Ali 
Published: April 2021

ABSTRACTThis paper aims to determine the types and contents of protein, fatty acids, amino acids and protein in the gonads of Arbacia lixula, Colobocentrotus atratus, Heterocentrotus trigonarius and Echinotrix diadema from the waters of Drini, Gunung Kidul, Yogyakarta. Kjedal method was used to analyze the protein content, while GC and HPLC methods were employed to analyze amino acids in this study. The results showed that the protein contents of each sample, consequently from highest to lowest, were Heterocentrotus trigonarius (13.3 %), Echinotrix diadema (10.86), Colobocentrotus atratus (10.41) and Arbacia lixula (9.90%). Amino acids analysis from all identified both saturated fatty acids, consisting of lauric acid, myristic acid, palmitic acid, stearic acid, arachidonic acid, lignoceric acid, as well as non-saturated fatty acids, consisting of palmitoleic acid, oleic acid, linoleic acid, erucic acid, EPA, and DHA. The highest contents of non-saturated fatty acids were identified in Colobocentrotus atratus (434.14 mg/100g) and the lowest content in Arbacia lixula (197.71 mg/100g). The highest percentage of essential fatty acids was found in Heterocentrotus trigonarius (0.29%), whereas the lowest was found in Echinotrix diadema (0.19 %). It is concluded that the gonad of Heterocentrotus trigonarius showed the highest protein and essential fatty acids contents. This study also found that Colobocentrotus atratus sea urchin gonads possess the highest content of non-saturated fatty acids (434.14 mg/100g). Keywords: amino acid, fatty acid, protein, sea urchin gonad.
Aalenian–Lower Bajocian Foraminiferal Fauna from the Ammonitico Rosso Series of Bakonycsernye (Hungary). Part 1: Taxonomy and Biostratigraphy
Authors: Zsiborás Gábor , Görög Ágnes 
Published: April 2021

AbstractThis paper provides the first record of isolated foraminiferal assemblages from the continuous Aalenian–lower Bajocian succession from the pelagic region of the Neotethys. The studied Tűzkövesárok section B of Bakonycsernye (Hungary) has been well dated by ammonites and consists of Ammonitico Rosso type limestones. The foraminiferal fauna extracted by glacial acetic acid yielded 49 benthic taxa (species and subspecies); protoglobigerinids also occurred. Most specimens belonged to the suborder Spirillinina, followed by the suborder Lagenina and Rotaliina; agglutinated forms were subordinate and miliolids were absent. The majority of the species have wide stratigraphic ranges; moreover, the distributions of 11 species changed based on their appearances in this section. Nevertheless, the Aalenian and Bajocian parts of the section could be distinguished based upon the stratigraphic distributions of some species.
Discovery of metabolic biomarkers for gestational diabetes mellitus in a Chinese population
Authors: Lu Wenqian , Luo Mingjuan , Fang Xiangnan , Zhang Rong , Tang Mengyang , Yu Xiangtian , Hu Cheng 
Published: April 2021

Abstract
Background: Gestational diabetes mellitus (GDM), one of the most common pregnancy complications, can lead to morbidity and mortality in both the mother and the infant. Metabolomics has provided new insights into the pathology of GDM and systemic analysis of GDM with metabolites is required for providing more clues for GDM diagnosis and mechanism research. This study aims to reveal metabolic differences between normal pregnant women and GDM patients in the second- and third-trimester stages and to confirm the clinical relevance of these new findings.Methods: Metabolites were quantitated with the serum samples of 200 healthy pregnant women and 200 GDM women in the second trimester, 199 normal controls, and 199 GDM patients in the third trimester. Both function and pathway analyses were applied to explore biological roles involved in the two sets of metabolites. Then the trimester stage-specific GDM metabolite biomarkers were identified by combining machine learning approaches, and the logistic regression models were constructed to evaluate predictive efficiency. Finally, the weighted gene co-expression network analysis method was used to further capture the associations between metabolite modules with biomarkers and clinical indices. Results: This study revealed that 57 differentially expressed metabolites (DEMs) were discovered in the second-trimester group, among which the most significant one was 3-methyl-2-oxovaleric acid. Similarly, 72 DEMs were found in the third-trimester group, and the most significant metabolites were ketoleucine and alpha-ketoisovaleric acid. These DEMs were mainly involved in the metabolism pathway of amino acids, fatty acids and bile acids. The logistic regression models for selected metabolite biomarkers achieved the area under the curve values of 0.807 and 0.81 for the second- and third-trimester groups. Furthermore, significant associations were found between DEMs/biomarkers and GDM-related indices. Conclusions: Metabolic differences between healthy pregnant women and GDM patients were found. Associations between biomarkers and clinical indices were also investigated, which may provide insights into pathology of GDM.
Detecting Vulnerability in Source Code Using CNN and LSTM Network
Authors: Guo Junjun , Wang Zhengyuan , Li Haonan , Xue Yang 
Published: April 2021

Abstract
Vulnerabilities can have very serious consequences for information security, with huge implications for economic, social, and even national security. Automated vulnerability detection has always been a keen topic for researchers. From traditional manual vulnerability mining to static detection and dynamic detection, all rely on human experts to define features. The rapid development of machine learning and deep learning has alleviated the tedious task of manually defining features by human experts while reducing the lack of objectivity caused by human subjective awareness. However, we still need to find an objective characterization method to define the features of vulnerabilities. Therefore, we use code metrics for code characterization, which are sequences of metrics that represent code. To use code metrics for vulnerability detection, we propose VulnExplore, a deep learning-based vulnerability detection model that uses a composite neural network of CNN + LSTM for feature extraction and learning of code metrics. Experimental results show that VulnExplore has a lower false positive rate, a lower miss rate, and a better accuracy rate compared to other deep learning-based vulnerability detection models.
Climate-driven Model Based on Long Short-Term Memory and Bayesian Optimization for Multi-day-ahead Daily Streamflow Forecasting
Authors: Lian Yani , Luo Jungang , Wang Jingmin , Zuo Ganggang 
Published: April 2021

Abstract
Many previous studies have developed decomposition and ensemble models to improve runoff forecasting performance. However, these decomposition-based models usually introduce large decomposition errors into the modeling process. Since the variation in runoff time series is greatly driven by climate change, many previous studies considering climate change focused on only rainfall-runoff modeling, with few meteorological factors as input. Therefore, a climate-driven streamflow forecasting (CDSF) framework was proposed to improve the runoff forecasting accuracy. This framework is realized using principal component analysis (PCA), long short-term memory (LSTM) and Bayesian optimization (BO) referred to as PCA-LSTM-BO. To validate the effectiveness and superiority of the PCA-LSTM-BO method with which one autoregressive LSTM model and two other CDSF models based on PCA, BO, and either support vector regression (SVR) or, gradient boosting regression trees (GBRT), namely, PCA-SVR-BO and PCA-GBRT-BO, respectively, were compared. A generalization performance index based on the Nash-Sutcliffe efficiency (NSE), called the GI(NSE) value, is proposed to evaluate the generalizability of the model. The results show that (1) the proposed model is significantly better than the other benchmark models in terms of the mean square error (MSE<=185.782), NSE>=0.819, and GI(NSE) <=0.223 for all the forecasting scenarios; (2) the PCA in the CDSF framework can improve the forecasting capacity and generalizability; (3) the CDSF framework is superior to the autoregressive LSTM models for all the forecasting scenarios; and (4) the GI(NSE) value is demonstrated to be effective in selecting the optimal model with a better generalizability.
Analysis of the non-periodic oscillations of a self-excited friction-damped system with closely-spaced modes
Authors: Woiwode Lukas , Vakakis Alexander F. , Krack Malte 
Published: April 2021

Abstract
It is widely known that dry friction damping can bound the self-excited vibrations induced by negative damping. The vibrations typically take the form of (periodic) limit cycle oscillations. However, when the intensity of the self-excitation reaches a condition of maximum friction damping, the limit cycle loses stability via a fold bifurcation. The behavior may become even more complicated in the presence of any internal resonance conditions. In this work, we consider a two-degree-of-freedom system with an elastic dry friction element (Jenkins element) having closely spaced natural frequencies. The symmetric in-phase motion is subjected to self-excitation by negative (viscous) damping, while the symmetric out-of-phase motion is positively damped. In a previous work, we showed that the limit cycle loses stability via a secondary Hopf bifurcation, giving rise to quasi-periodic oscillations. A further increase of the self-excitation intensity may lead to chaos and finally divergence, long before reaching the fold bifurcation point of the limit cycle. In this work, we use the method of Complexification-Averaging to obtain the slow flow in the neighborhood of the limit cycle. This way, we show that chaos is reached via a cascade of period doubling bifurcations on invariant tori. Using perturbation calculus, we establish analytical conditions for the emergence of the secondary Hopf bifurcation and approximate analytically its location. In particular, we show that non-periodic oscillations are the typical case for prominent nonlinearity, mild coupling (controlling the proximity of the modes) and sufficiently light damping. The range of validity of the analytical results presented herein is thoroughly assessed numerically. To the authors' knowledge, this is the first work that shows how the challenging Jenkins element can be treated formally within a consistent perturbation approach in order to derive closed-form analytical results for limit cycles and their bifurcations.