bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of automatic control structure of transfer pipeline stations on reclamation channels
Authors: Ali M S , Beglyarov D S , Nazarkin E E , Korchevskaya Yu V , Trotsenko I A 
Published: March 2021

Abstract
Hydro-reclamation system operation management comes down to the management of pumping stations and dams. Transfer pumping stations are one of the most complex, critical and energy-rich local management objects on the channels of irrigation and drainage systems. These stations are complex aggregates of hydromechanical and electrical equipment, whose optimization can be rather significant, and are important elements determining the quality of a hydro-reclamation system as a whole. The main function of the automatic control system for transfer pumping stations is providing solutions on the optimal way to compensate for mismatches arising in the system “channel-transfer pumping station” and finding the best way to compensate for these mismatches with the available means. The first problem is hydrodynamic and is solved by studying a mathematical model of the pool, coupled with a transfer pumping station. The solution of the second problem is associated with regarding the technical characteristics and condition of the equipment of the transfer pumping station and the permissible operating modes of the channel. The article discusses one of the methods for determining the mismatch in the system “channel-transfer pumping station”, which contributes to building economical and efficient control systems for transfer pumping stations.
Problems and prospects of using mobile devices when performing operational monitoring of water supply structures
Authors: Bandurin M A , Yurchenko I F , Bandurina I P , Bandurin A P 
Published: March 2021

Abstract
This article presents the results of work on a mobile device for conducting operational monitoring of the technical condition of water supply structures, designed to determine various parameters of defects and damages, as well as calculate the projected remaining life of their elements. The modern development of mobile devices, network computer technologies, cellular communication and mathematical methods opens up new prospects in the automation of operational monitoring of water supply structures. The technical part of the mobile device for conducting operational monitoring includes various technical schemes of frames for each water supply structure separately. It can be used for conducting operational monitoring of the technical condition and determining the remaining life of the protective coating of water supply channels and soils under them, identifying dangerous defects and damages, as well as evaluating and predicting its technical condition and further suitability for operation. The technical result achieved by this mobile device is to identify the influence of defects and damages, both of the protective coating itself and the condition of the soil located under it, on the formation of decompressions and subsidence at an early stage of their formation. The mobile device is developed using the Data Mining database management system and Microsoft Access. The use of a mobile device makes it possible to improve the quality of operational monitoring of water supply channels due to the fact that the survey is carried out over the entire cross-section of the water supply channel for defects, damages, decompression and subsidence of the soil under the structure by non-destructive testing methods. And the presence of a vehicle that transports the complex allows you to speed up significantly the survey of water supply channels.
Development of a methodology for automated control of the reliability indicators of the designed roads in the framework of the program-targeted approach
Authors: Bazhanov A P , Shamanov R S 
Published: March 2021

Abstract
At present, the reliability of domestic roads in terms of their main indicators is significantly inferior to the reference indicators of the reliability of roads in advanced world countries. In this regard, in the field of modern road construction in the country, the task arises of strengthening the requirements for the reliability indicators of domestic roads and the transition from passive methods of ensuring these indicators to active methods of managing the reliability indicators of the country’s roads at the stages of their design and stages of construction, reconstruction, overhaul, repair and maintenance. The work proposes a new program-targeted approach based on a functional model for managing the reliability indicators of roads, based on the implementation of procedures for forecasting, planning, rationing, accounting, control, analysis, regulation, and feedback, which are the initial components of the process of managing these reliability indicators of the designed roads. The main advantages of the proposed functional program-target approach to the management of the reliability indicators of roads are stated, which consist of its consistency and fairly complete development of the mathematical apparatus used in it.
Principles of protection, storage and movement of documents during electronic document flow within and outside the organization
Authors: Daudov Kh A , Zinoviev A A , Gavrilova Zh L 
Published: March 2021

Abstract
Today, electronic document management refers to a documentation management system in which the entire array of created, transmitted and stored documents is supported using technologies on computers combined into a network structure, which provides the ability to form and maintain a distributed database.
Classification of heavy high-viscosity oils for improving the efficiency of reservoir development
Authors: Mingulov I Sh , Mukhametshin V V , Mingulov Sh G , Kuleshova L S 
Published: March 2021

Abstract
The article aims to study the influence of oil viscosity on its density in order to obtain a statistical dependence. The influence of oil density on the rheological behavior of the liquid was established, the boundaries of the dependences were determined and the reasons for its growth anomalies were revealed. The results were obtained by generalizing the measurement of viscosity of degassed oils from various oil and gas producing provinces of Russia. They make it possible to study the physicochemical characteristics of high viscosity oils for their effective production.
Rationale for choosing the sound-absorbing materials for the operator’s cabins of the rail-grinding machine
Authors: Nazaretov A A , Yaitskov I A , Yaitskova N M 
Published: March 2021

Abstract
The operation of the rail grinding machines that use noise and vibration-active parts in their structures inevitably leads to the increased levels of vibration and noise that adversely affect their operators. In this field, the specialists from different countries have carried out certain studies. However, the process of forming the vibro acoustic characteristics of the rail grinding machines has not been studied. It should be also noted that theoretical studies of the vibro acoustic dynamics of the rail grinding machines and methods for calculating the vibration and noise spectra are limited, which significantly complicates the substantiation of the engineering solutions to reduce the sound emission intensity of the dominant noise sources. Due to the negative impact of the elevated noise levels on rail grinding machine’s operators, it is necessary for the design stages with appropriate vibro acoustic characteristics that meet requirements of the sanitary standards. The main practically and technologically possible way to align noise emission level is the choice of the sound-absorbing materials and the achievement of the sound insulation, based on the fulfillment of the sanitary noise standards. The article describes the rationale for choosing the sound-absorbing materials for the operator’s cabin of the rail-grinding machine due to the reduction of the air noise component, which is more common than the structural one. A criterion for minimizing acoustic characteristics inside the operator’s cabin is determined to select the most rational engineering method of the sound absorption.
Features of information visualization in coal quarrying
Authors: Zhigalov K Yu , Turluyev R R , Druzhinina T Ya 
Published: March 2021

Abstract
Today, such areas as coal mining, construction of large facilities, providing enterprises with coal (crushed stone, sand, etc.) reserves, etc., face a problem of providing all employees of a coal mining company with equally understandable information. This is bound to different qualifications of the majority of employees. However, as practice shows, the meaningful use of geographic information systems requires certain skills. Based on the aforesaid, it is possible to conclude that in order to be equally able to use the same information system by different employees, its maximum visualization and simplification of the graphical user interface are required. The results of the studies made it possible to test the presentation pattern by grouping the main functions of the software.
Transmission type parallel to ship with hybrid power plant
Authors: Dobretsov R Yu , Dobretsova S B , Vasiliev A I 
Published: March 2021

Abstract
The kinematic scheme of a two-stream transmission is considered, which makes it possible to implement the principle of using two engines (including those using different physical principles and having different energy characteristics) and to implement the idea of design a hybrid power plant, including one adapted for operation on a driverless ship. The result of the research is the structural diagram of the transmission, the kinematic diagram of the summing gear in its composition and proposals for the implementation of the main units of the summing gear. The gearbox allows for smooth connection or disconnection of selected motors to the payload. The considered power plant combines an internal combustion engine and a traction motor. The main benefit is increased reliability through redundant motors. Improvements in efficiency are expected by ensuring consistent engine performance. The composition, the kinematic diagram, the principle of the transmission are proposed. The equations describing the kinematic and force relations in the summing gear are considered. The used method of kinematic and force analysis has been tested in the machine-building industry in relation to planetary gears as part of highly loaded transmissions of wheeled and tracked vehicles. References are given to technical solutions that make it possible to implement the proposed transmission based on the technological capabilities mastered by Russian manufacturers. The proposed scheme seems to be promising for use on ships for various purposes, including military boats, in the power plant of which a gas turbine engine is used.
Passive frequency conversion of ultraviolet images into the visible using perovskite nanocrystals
Authors: Salman Jad , Gangishetty Mahesh K , Rubio-Perez Bryan E , Feng Demeng , Yu Zhaoning , Yang Zongzhen , Wan Chenghao , Frising Michel , Shahsafi Alireza , Congreve Daniel N , Kats Mikhail A 
Published: March 2021

AbstractWe demonstrate a passive down-conversion imaging system that converts broadband ultraviolet light to narrow-band green light while preserving the directionality of rays, and thus enabling direct down-conversion imaging. At the same time our system has high transparency in the visible, enabling superimposed visible and ultraviolet imaging. The frequency conversion is performed by a subwavelength-thickness transparent downconverter based on highly efficient CsPbBr3nanocrystals incorporated into the focal plane of a simple telescope or relay-lens geometry. The resulting imaging performance of this down-conversion system approaches the diffraction limit. This demonstration sets the stage for the incorporation of other high-efficiency perovskite nanocrystal materials to enable passive multi-frequency conversion imaging systems.
Optical vortex beams with the infinite topological charge
Authors: Kovalev Alexey A , Kotlyar Victor V 
Published: March 2021

Abstract
Up to now, Gaussian optical vortices (OVs) were investigated with the finite topological charge (TC). Here, we study an OV with the infinite TC. Such OVs have a countable number of phase singularities (isolated intensity nulls), which typically have the unitary TC and are located either equidistantly or not equidistantly on a straight line in the beam transverse cross section. Such OVs are structurally stable (form-invariant) and their transverse intensity is conserved on propagation, changing only in scale and rotation. Orbital angular momentum (OAM) of such OVs is finite, since only a finite number of screw dislocations are within the Gaussian beam in the area of notable intensity, whereas the other phase singularities are in the periphery (and in the infinity), where the intensity is very small. Increasing the Gaussian beam waist radius leads to the parabolic growth of the OAM of such beams. A unique feature of these beams is that their normalized OAM can be adjusted (both increased and decreased) by simple change of the waist radius of the Gaussian beam. In addition to the two form-invariant beams, we studied a Gaussian beam with a countable number of edge dislocations (zero-intensity lines), which is not form-invariant, but, after an astigmatic transform by a cylindrical lens, also becomes an infinite-topological-charge beam.
Associations Between Everyday Discrimination and Sleep: Tests of Moderation by Ethnicity and Sense of Purpose
Authors: Hill Patrick L , Sin Nancy L , Edmonds Grant W , Burrow Anthony L 
Published: March 2021

Abstract

Background
Everyday discrimination holds pernicious effects across most aspects of health, including a pronounced stress response. However, work is needed on when discrimination predicts sleep outcomes, with respect to potential moderators of these associations.

Purpose
The current study sought to advance the past literature by examining the associations between everyday discrimination and sleep outcomes in an ethnically diverse sample, allowing tests of moderation by ethnic group. We also examined the role of sense of purpose, a potential resilience factor, as another moderator.

Methods
Participants in the Hawaii Longitudinal Study of Personality and Health (n = 758; 52.8% female; mage: 60 years, sd = 2.03) completed assessments for everyday discrimination, sleep duration, daytime dysfunction due to sleep, sleep quality, and sense of purpose.

Results
In the full sample, everyday discrimination was negatively associated with sleep duration, sleep quality, and sense of purpose, while positively associated with daytime dysfunction due to sleep. The associations were similar in magnitude across ethnic groups (Native Hawaiian, White/Caucasian, Japanese/Japanese-American), and were not moderated by sense of purpose, a potential resilience factor.

Conclusions
The ill-effects on health due to everyday discrimination may operate in part on its role in disrupting sleep, an issue that appears to similarly impact several groups. The current research extends these findings to underrepresented groups in the discrimination and sleep literature. Future research is needed to better disentangle the day-to-day associations between sleep and discrimination, and identify which sources of discrimination may be most problematic.
Identification of viral-mediated pathogenic mechanisms in neurodegenerative diseases using network-based approaches
Authors: Onisiforou Anna , Spyrou George M 
Published: March 2021

Abstract
During the course of a viral infection, virus–host protein–protein interactions (PPIs) play a critical role in allowing viruses to replicate and survive within the host. These interspecies molecular interactions can lead to viral-mediated perturbations of the human interactome causing the generation of various complex diseases. Evidences suggest that viral-mediated perturbations are a possible pathogenic etiology in several neurodegenerative diseases (NDs). These diseases are characterized by chronic progressive degeneration of neurons, and current therapeutic approaches provide only mild symptomatic relief; therefore, there is unmet need for the discovery of novel therapeutic interventions. In this paper, we initially review databases and tools that can be utilized to investigate viral-mediated perturbations in complex NDs using network-based analysis by examining the interaction between the ND-related PPI disease networks and the virus–host PPI network. Afterwards, we present our theoretical-driven integrative network-based bioinformatics approach that accounts for pathogen–genes–disease-related PPIs with the aim to identify viral-mediated pathogenic mechanisms focusing in multiple sclerosis (MS) disease. We identified seven high centrality nodes that can act as disease communicator nodes and exert systemic effects in the MS-enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways network. In addition, we identified 12 KEGG pathways, 5 Reactome pathways and 52 Gene Ontology Immune System Processes by which 80 viral proteins from eight viral species might exert viral-mediated pathogenic mechanisms in MS. Finally, our analysis highlighted the Th17 differentiation pathway, a disease communicator node and part of the 12 underlined KEGG pathways, as a key viral-mediated pathogenic mechanism and a possible therapeutic target for MS disease.
IsAb: a computational protocol for antibody design
Authors: Liang Tianjian , Chen Hui , Yuan Jiayi , Jiang Chen , Hao Yixuan , Wang Yuanqiang , Feng Zhiwei , Xie Xiang-Qun 
Published: March 2021

Abstract
The design of therapeutic antibodies has attracted a large amount of attention over the years. Antibodies are widely used to treat many diseases due to their high efficiency and low risk of adverse events. However, the experimental methods of antibody design are time-consuming and expensive. Although computational antibody design techniques have had significant advances in the past years, there are still some challenges that need to be solved, such as the flexibility of antigen structure, the lack of antibody structural data and the absence of standard antibody design protocol. In the present work, we elaborated on an in silico antibody design protocol for users to easily perform computer-aided antibody design. First, the Rosetta web server will be applied to generate the 3D structure of query antibodies if there is no structural information available. Then, two-step docking will be used to identify the binding pose of an antibody–antigen complex when the binding information is unknown. ClusPro is the first method to be used to conduct the global docking, and SnugDock is applied for the local docking. Sequentially, based on the predicted binding poses, in silico alanine scanning will be used to predict the potential hotspots (or key residues). Finally, computational affinity maturation protocol will be used to modify the structure of antibodies to theoretically increase their affinity and stability, which will be further validated by the bioassays in the future. As a proof of concept, we redesigned antibody D44.1 and compared it with previously reported data in order to validate IsAb protocol. To further illustrate our proposed protocol, we used cemiplimab antibody, a PD-1 checkpoint inhibitor, as an example to showcase a step-by-step tutorial.
Comparative phylogenetic analysis of SARS-CoV-2 spike protein—possibility effect on virus spillover
Authors: Ghorbani Abozar , Samarfard Samira , Eskandarzade Neda , Afsharifar Alireza , Eskandari Mohammad Hadi , Niazi Ali , Izadpanah Keramatollah , Karbanowicz Thomas P 
Published: March 2021

AbstractCoronavirus disease 2019 has developed into a dramatic pandemic with tremendous global impact. The receptor-binding motif (RBM) region of the causative virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), binds to host angiotensin-converting enzyme 2 (ACE2) receptors for infection. As ACE2 receptors are highly conserved within vertebrate species, SARS-CoV-2 can infect significant animal species as well as human populations. An analysis of SARS-CoV-2 genotypes isolated from human and significant animal species was conducted to compare and identify mutation and adaptation patterns across different animal species. The phylogenetic data revealed seven distinct phylogenetic clades with no significant relationship between the clades and geographical locations. A high rate of variation within SARS-CoV-2 mink isolates implies that mink populations were infected before human populations. Positions of most single-nucleotide polymorphisms (SNPs) within the spike (S) protein of SARS-CoV-2 genotypes from the different hosts are mostly accumulated in the RBM region and highlight the pronounced accumulation of variants with mutations in the RBM region in comparison with other variants. These SNPs play a crucial role in viral transmission and pathogenicity and are keys in identifying other animal species as potential intermediate hosts of SARS-CoV-2. The possible roles in the emergence of new viral strains and the possible implications of these changes, in compromising vaccine effectiveness, deserve urgent considerations.
FraGAT: a fragment-oriented multi-scale graph attention model for molecular property prediction
Authors: Zhang Ziqiao , Guan Jihong , Zhou Shuigeng 
Published: March 2021

Abstract

Motivation
Molecular property prediction is a hot topic in recent years. Existing graph-based models ignore the hierarchical structures of molecules. According to the knowledge of chemistry and pharmacy, the functional groups of molecules are closely related to its physio-chemical properties and binding affinities. So, it should be helpful to represent molecular graphs by fragments that contain functional groups for molecular property prediction.

Results
In this article, to boost the performance of molecule property prediction, we first propose a definition of molecule graph fragments that may be or contain functional groups, which are relevant to molecular properties, then develop a fragment-oriented multi-scale graph attention network for molecular property prediction, which is called FraGAT. Experiments on several widely used benchmarks are conducted to evaluate FraGAT. Experimental results show that FraGAT achieves state-of-the-art predictive performance in most cases. Furthermore, our case studies show that when the fragments used to represent the molecule graphs contain functional groups, the model can make better predictions. This conforms to our expectation and demonstrates the interpretability of the proposed model.

Availability and implementation
The code and data underlying this work are available in GitHub, at https://github.com/ZiqiaoZhang/FraGAT.

Supplementary information
Supplementary data are available at Bioinformatics online.