bluuebunny/crossref_metadata_2025_split huggingface dataset:
Healthcare Data Security and Privacy Protection Framework Based on Dual Channel Blockchain
Authors: Kaur Jasleen , Rani Rinkle , Kalra Nidhi 
Published: January 2025

ABSTRACTThe integration of blockchain technology with healthcare digitalization has the potential to improve data management, reduce administrative costs, increase data security and privacy, and enhance querying capabilities. However, in the traditional blockchain model, all data and transactions are processed and stored in a single, unified ledger, and all participants have access to the same data, which raises privacy concerns and poses congestion issues with an increased number of transactions. It becomes even more problematic in healthcare, where data confidentiality is essential. In literature, centralized storage utilizing cloud‐based solutions is employed to manage large volumes of data, restricting information sharing beyond the institution. Additionally, the direct storage of massive data on the blockchain impacts the performance and scalability of the system. In this paper, to address these issues and ensure the security and rapid retrieval of healthcare information, a framework is proposed, which involves the implementation of a dual‐channel blockchain architecture combined with two robust cryptographic algorithms, i.e., Rivest‐Shamir‐Adleman (RSA) and Advanced Encryption Standard (AES). These encryption techniques deliver safe data transmission via RSA and efficient data storage via AES, offering a secure mechanism to prevent unauthorized access and data breaches. In addition, private data collection is incorporated to securely store confidential patient information, guaranteeing privacy, security, and limited access. Also, an Access Control List (ACL) is defined for different users to implement access permissions, i.e., grant and revoke access to viewers while sharing information. Moreover, an off‐chain storage InterPlanetary File System (IPFS) is used to improve scalability. The performance evaluation is performed by conducting experimental simulations, where critical performance indicators such as throughput and latency are measured across different transaction rates, channels, and rate controllers. Moreover, the proposed framework classifies smart contract functions into query and invoke/write transactions, enhancing the efficiency of data retrieval. Further, the functionality and security analysis of the proposed framework is discussed. The results demonstrate that the proposed approach is highly capable of preserving security and privacy standards while also assuring efficient management and accessibility of data in healthcare applications.
High‐Order Alternative Formulation of Weighted Essentially Non‐Oscillatory Scheme With Minimized Dispersion and Controllable Dissipation for Compressible Flows
Authors: Zeng Wei‐Gang , Liu Lu , Zeng Li‐Jin , Pan Jian‐Hua , Yin Jun‐Ping , Ren Yu‐Xin 
Published: January 2025

ABSTRACTFollowing the proposition of the original AWENO (Alternative Formulation of Weighted Essentially Non‐Oscillatory) FD (Finite Difference) scheme, we construct the new AMDCD FD scheme, an Alternative formulation of the linear FD scheme with Minimized Dispersion and Controllable Dissipation, in this article. Spectral analysis shows that the proposed AMDCD FD scheme can be more efficient in resolving smooth solutions due to the flexibility in controlling dissipation. To efficiently solve compressible flows with discontinuities, we further combined the proposed AMDCD FD scheme with the original AWENO FD scheme using a hybrid interpolation scheme, in which the optimized linear MDCD (Minimized Dispersion and Controllable Dissipation) interpolation scheme would be switched to the nonlinear WENO (Weighted Essentially Non‐Oscillatory) type interpolation scheme gradually as the flow structures are in transition from smooth region towards the vicinity of discontinuities. Therefore, the resulting hybrid AWENO‐AMDCD FD scheme is suitable for solving compressible flows with broad‐scale flow structures and/or shock waves. A series of one‐, two‐, and three‐dimensional compressible flow problems are numerically tested to demonstrate the accuracy, superior resolution, as well as the robustness of the proposed hybrid AWENO‐AMDCD FD scheme.
Glial Biologist's Guide to Mass Spectrometry‐Based Lipidomics: A Tutorial From Sample Preparation to Data Analysis
Authors: Randolph Caitlin E. , Walker Katherine A. , Yu Ruilin , Beveridge Connor , Manchanda Palak , Chopra Gaurav 
Published: January 2025

ABSTRACTNeurological diseases are associated with disruptions in the brain lipidome that are becoming central to disease pathogenesis. Traditionally perceived as static structural support in membranes, lipids are now known to be actively involved in cellular signaling, energy metabolism, and other cellular activities involving membrane curvature, fluidity, fusion or fission. Glia are critical in the development, health, and function of the brain, and glial regulation plays a major role in disease. The major pathways of glial dysregulation related to function are associated with downstream products of metabolism including lipids. Taking advantage of significant innovations and technical advancements in instrumentation, lipidomics has emerged as a popular omics discipline, serving as the prevailing approach to comprehensively define metabolic alterations associated with organismal development, damage or disease. A key technological platform for lipidomics studies is mass spectrometry (MS), as it affords large‐scale profiling of complex biological samples. However, as MS‐based techniques are often refined and advanced, the relative comfort level among biologists with this instrumentation has not followed suit. In this review, we aim to highlight the importance of the study of glial lipids and to provide a concise record of best practices and steps for MS‐based lipidomics. Specifically, we outline procedures for glia lipidomics workflows ranging from sample collection and extraction to mass spectrometric analysis to data interpretation. To ensure these approaches are more accessible, this tutorial aims to familiarize glia biologists with sample handling and analysis techniques for MS‐based lipidomics, and to guide non‐experts toward generating high quality lipidomics data.
The Future Hospital in Global Health Systems: The Future Hospital as an Entity
Authors: Sebire N. J. , Adams A. , Arpiainen L. , Celi L. , Charlesworth A. , Gorgens M. , Gorsky M. , Magrabi F. , Nagasawa Y. , Onoka C. , McKee M. 
Published: January 2025

ABSTRACTHealth care is changing rapidly. Hospitals are, and will remain, an essential setting to deliver it. We discuss how to maximise the benefits of hospitals in the future in different geographic and health system settings, highlighting a series of cross‐cutting issues. We do this by exploring the evolving roles of hospitals and the main factors that we must consider as they adapt. These include changing population and disease profiles, the impact of evolving technology, and new concepts in hospital design and planning.Our focus is on delivering high‐quality, patient‐centred care while ensuring equitable access, even if strategic decisions require compromise across these functions. The COVID‐19 pandemic has shown the importance of hospitals in societies while also revealing the limitations of current structures and the potential of technology to transform hospital services within the broader healthcare system.The aim of this multidisciplinary perspective is to provide an overview of pertinent issues whilst highlighting the challenges and opportunities in optimising future hospital planning, construction, design, and development in high‐income (HIC) and low —and medium‐income country (LMIC) settings.
Neo‐enhancers in T‐cell acute lymphoblastic Leukaemia (T‐ALL) and beyond
Authors: Smith Charlotte , Asnafi Vahid , Touzart Aurore 
Published: January 2025

AbstractT‐cell acute lymphoblastic leukaemia (T‐ALL) is a rare aggressive haematological malignancy characterised by the clonal expansion of immature T‐cell precursors. It accounts for 15% of paediatric and 25% of adult ALL. T‐ALL is associated with the overexpression of major transcription factors (TLX1/3, TAL1, HOXA) that drive specific transcriptional programmes and constitute the molecular classifying subgroups of T‐ALL. Although the dysregulation of transcription factor oncogenes is frequently associated with chromosomal translocations in T‐ALL, epigenetic dysregulation resulting in changes to post‐translational modifications of histones has also been reported. This includes non‐coding intergenic mutations that form oncogenic neo‐enhancers. This review will focus on the known epigenetically activating intergenic mutations reported in T‐ALL, and will discuss the wider implications of neo‐enhancer mutations in cancer.
A case of laparoscopically assisted vulvar reconstruction using the gluteal fold flap for anterior enterocele after robot‐assisted radical cystectomy in a woman
Authors: Sasaki Yutaro , Yamamoto Yasuyo , Mizuguchi Makoto , Kobayashi Saki , Nagasaka Shinji , Tokunaga Takuya , Furukawa Junya 
Published: January 2025

IntroductionVaginal complications following radical cystectomy may require surgical treatment. We herein report a case of successful laparoscopically assisted vulvar reconstruction using the gluteal fold flap for anterior enterocele following robot‐assisted radical cystectomy.Case presentationA 71‐year‐old Japanese woman underwent robot‐assisted radical cystectomy for bladder cancer (ypT1ypN1M0). The bladder, urethra, bilateral ovaries, and anterior vaginal wall were removed together transvaginally. The Mercedes‐Benz closure technique was performed for vaginal reconstruction using the posterior vaginal wall. Seventeen months after surgery, she complained of a vulvar bulge, and physical examination confirmed a tennis ball‐sized anterior enterocele. Therefore, she underwent laparoscopically assisted vulvar reconstruction using the gluteal fold flap. No recurrence had developed at 6 months postoperatively.ConclusionThe combination with laparoscopy allows vulvar reconstruction to be performed safely and efficiently.
Paranoia, Functioning, and the Moderating Effect of Well‐Being in a Community Sample of Adolescents
Authors: Thompson Elizabeth , Kingston Jessica , Ellett Lyn , Krkovic Katarina , Velotta Sydney , Rabasco Ana , Gaudiano Brandon A. 
Published: January 2025

ABSTRACTIntroductionParanoid ideation is a relatively common experience in adolescence, yet it has not been well‐explored in relation to psychological well‐being and functioning in general population samples of youth. The current study aimed to investigate the relations between paranoia (operationalized as “persecutory ideation”), well‐being, and two domains of functioning, social (e.g., interpersonal relationships) and role (e.g., school and home responsibilities), in adolescence.MethodsThis nonclinical sample of adolescents (n = 462, aged 14–17 years, 50% male, 50% female) was recruited from the United Kingdom and the United States via an online survey in 2022.ResultsCorrelations indicated significant associations between persecutory ideation, in the negative direction, and well‐being, in the positive direction, with both social and role functioning. With respect to social, but not role, functioning, these associations remained significant in linear regression analyses controlling for the effects of depression, past‐year bullying/victimization, and past‐year adverse life events. A subsequent analysis indicated that the association between persecutory ideation and social functioning was moderated by well‐being. Persecutory ideation was significantly associated with social functioning at the lowest level of well‐being (1 SD below the mean), but not at moderate (mean) or high (1 SD above the mean) levels of well‐being.ConclusionsResults suggest that among adolescents, persecutory ideation is negatively associated with functioning. Furthermore, novel findings suggest that well‐being may buffer the association between persecutory ideation and social functioning. Therapeutic interventions targeting well‐being may be helpful for youth experiencing paranoia, especially with respect to maintaining relationships and social connectedness.
Food Safety Evaluation of Recombinant Humanized Type III Collagen Produced by Komagataella phaffii SMD1168‐2COL3
Authors: Dai Qiu , Lemke Shawna , Lu Yuemei , Taylor Steve , Li Haihang , Fu Shengwei , Wu Xiaowen , Wang Nan , Xue Tian , He Xiaoyun 
Published: January 2025

ABSTRACTCollagens are biofunctional proteins that have been widely used in many fields, including biomedical, cosmetics, and skin care for their value in maintaining the integrity of cellular membranes. Collagens are also commonly consumed in foods and provide a source of protein and amino acids. As part of the safety assessment for this particular recombinant humanized type III (RHTypeIII) collagen produced by Komagataella phaffii SMD1168‐2COL3, a series of toxicological tests were conducted. This collagen has ≥ 90% amino acid sequence homology to bovine and porcine collagen. The RHTypeIII collagen showed no evidence of genotoxic potential in a battery of tests. It was not toxic in an acute oral study, with no effects at 10 g/kg BW. The RHTypeIII collagen was not developmentally toxic in Sprague Dawley (SD) rat, and the NOAEL was 4.5 g/kg BW/day. In a 90‐day oral gavage study in rats, there were no adverse findings observed; therefore, the high dose level (4.5 g/kg BW/day) was considered the NOAEL. The protein sequence was subjected to homology searches against the AllergenOnline database (sliding 80–amino acid windows and full sequence searches). From the 80‐amino acid alignment searches, 23 significant matches were identified (> 35% identity and E value < 1 × 10−7) to allergens of bovine, fish, anisakis, feverfew pollen, ragweed pollen, and wheat origin. Although matches were identified, further assessment of the in silico results combined with a literature review demonstrates that the risk of allergenic cross‐reactivity for this collagen is low. These results demonstrate RHTypeIII collagen is not toxic and unlikely to present a risk of allergy when used as a food ingredient.
Use of Dynamic Contrast‐Enhanced Magnetic Resonance Imaging Combined With Serum Carcinoembryonic Antigen and Carbohydrate Antigen 19‐9 in Predicting Colorectal Cancer Liver Metastasis
Authors: Ji Hong‐Bo , Qian Bo , Hu Jian‐Jun , Qi Wei , Che Zi‐Gang 
Published: January 2025

ABSTRACTBackgroundDynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) combined with serum carcinoembryonic antigen (CEA) and carbohydrate antigen 19‐9 (CA19‐9) levels to evaluate the efficacy of colorectal cancer liver metastasis (CRCLM) treatment is still rare.PurposeTo investigate the predictive value of DCE‐MRI combined with serum CEA and CA 19‐9 concerning the efficacy of comprehensive treatment for CRCLM.Materials and MethodsA total of 120 patients with CRC were retrospectively recruited using convenience sampling between May 2019 and March 2024. After treatment, they were divided into two groups according to the treatment efficacy: responders (86 cases) and non‐responders (34 cases), and their clinical data were collected for comparison.ResultsBefore treatment, there were statistically significant differences between the groups in terms of the proportion of positive CEA (χ2 = 17.364, p < 0.001), the proportion of positive CA 19‐9 (χ2 = 23.639, p < 0.001), the rate constant of a contrast agent from the vascular to the interstitial compartment (Ktrans) (χ2 = 2.341, p = 0.023), and the rate constant between the extravascular extracellular space (EES) (Kep) (χ2 = 2.556, p = 0.011). The values of Ktrans, Kep, CEA, and CA 19‐9 reflected a certain degree of predictive value for the efficacy of comprehensive treatment in patients with CRCLM (p < 0.05). The combination of the four measurements is better than any single value, with an area under the curve of 0.898 (95% CI: 0.833, 0.922).ConclusionDynamic contrast‐enhanced magnetic resonance imaging, CEA, and CA 19‐9 have predictive value for the early efficacy of comprehensive treatment for CRCLM.
The impact of same‐day and rapid ART initiation under the Universal Health Coverage programme on HIV outcomes in Thailand: a retrospective real‐life cohort study
Authors: Teeraananchai Sirinya , Boettiger David C. , Lertpiriyasuwat Cheewanan , Triamwichanon Rattaphon , Benjarattanaporn Patchara , Phanuphak Nittaya 
Published: January 2025

AbstractIntroductionAntiretroviral therapy (ART) initiation, regardless of CD4 count, has been recommended in Thailand since 2014, with same‐day initiation recommended since 2021. We assessed HIV treatment outcomes among Thai people living with HIV (PLHIV) by the time from HIV diagnosis to ART initiation under the Universal Health Coverage (UHC) programme and identified factors associated with virological failure (VF).MethodsPLHIV aged ≥15 years initiating ART between 2014 and 2022 were included from the UHC database. We categorized participants into four groups using the duration from HIV diagnosis to ART initiation: (1) ≤ 7 days (same‐day ART); (2) 8 days to <1 month; (3) 1–3 months; and (4) >3 months. Viral load (VL) was measured 6 months after starting ART, and annually thereafter. VF was defined as VL ≥1000 copies/ml. Factors associated with VF were analysed using competing risk models considering death and loss to follow‐up (LTFU) as competing events.ResultsAmong 252,239 PLHIV who started ART, the median age at initiation was 34 years (interquartile range [IQR]: 26–43 years). The median (IQR) pre‐ART CD4 count was 233 (76–420) cells/mm3. ART initiation occurred within 7 days for 25% (17% on the same day, 8% in 2–7 days), 24% in 8 days to <1 month, 23% in 1–3 months and 28% in >3 months. ART initiation within 7 days increased from 20% (2014–2016) to 32% (2021–2022). VF occurred with a rate of 3.11 (95% CI 3.07–3.159) per 100 person‐years (PYs). PLHIV initiating ART 8 days to 1 month were at lower risk of VF (aSHR 0.52, 95% CI 0.50–0.54) when compared to ART initiation >3 months. ART initiation within 7 days resulted in the lowest mortality (6%: 1.28 [95% CI 1.24–1.32] per 100 PYs), but the highest rate of LTFU (12%: 2.69 [95% CI 2.63–2.75] per 100 PYs) when compared to other ART initiation groups.ConclusionsAlthough ART initiation within 7 days has increased in Thailand, the overall rate of early initiation remains low. ART initiation within 1 month significantly lowered the risk of VF. ART initiation within 7 days significantly reduced mortality. To further optimize health outcomes, innovative strategies are urgently needed to promote earlier ART initiation in Thailand.
Aeroportia and pneumatosis intestinalis in infants with food protein‐induced‐allergic proctocolitis: A presentation of two cases
Authors: Ruesen Jessica , Gaitan Villela Clarissa , Xydias Theodoros , Kramer Freya , Daester Corinne , Koehler Henrik 
Published: January 2025

AbstractBloody stools are a particularly concerning symptom in neonates and infants. The differential diagnosis reaches from life‐threatening to benign conditions. We would like to present two infants, who presented to the paediatric emergency department with bloody stools and showed pneumatosis on ultrasonography, which initially led to the suspicion of a potentially life‐threatening condition. Both children had an unremarkable physical examination and both the laboratory chemical parameters, as well as the stool analyses were without abnormal findings. As in summary, there was no evidence of necrotizing enterocolitis, and Food Protein‐Induced Allergic Proctocolitis (FPIAP) was considered the most likely diagnosis, an ambulant nutritional counselling was provided. As FPIAP is a clinical diagnosis, the number of cases in which pneumatosis can be detected is unclear. It is speculated that, like atopic dermatitis, food allergies alter, for example, the tight junctions and lead to an increased intestinal permeability which might result in pneumatosis intestinalis.
Sodium nonylcyclohexanol ethoxylate sulfate‐based strategy for remediating dye‐contaminated soil with low surfactant adsorption
Authors: Hu Xueyi , Zhang Yongjin , Qian Fei , Liu Jianyi , Zhang Guiju , Xia Yongmei 
Published: January 2025

AbstractSurfactant‐assisted soil cleaning has been considered as a promising technology for remediating of dye‐contaminated soil, but is significantly impeded by limitations such as the adsorption or precipitation of surfactants in soil. To take the advantage of effective remediation of anionic surfactant and lower adsorption of nonionic surfactant, a remediation system has been developed in this study for soil contaminated with model dyes methyl orange and alizarin red, employing a designed anionic‐nonionic surfactant known as sodium nonylcyclohexanol ethoxylates sulfate (NCEO5S) and a commercial surfactant—sodium alkyl alcohol ethoxylate sulfate (AES). Using simple wash, the elution efficiency on highly‐contaminated soil (methyl orange and alizarin red) reached up to 94.34% and 97.66%, respectively, at 25°C in 24 h with 1 wt% of surfactant solution. Electrostatic repulsion noticeably mitigates surfactant adsorption on the soil surface. The low adsorption of surfactants on the eluted soil surface was characterized with SEM‐EDS and thermogravimetric analysis. The kinetics of surfactant‐enhanced dyes desorption from contaminated soil follow the Elovich equation. The findings will be benefit for developing eco‐friendly surfactant systems to clean‐up dyes‐contaminated soils while minimizing surfactant adsorption.
Craniofacial Pain Locations and Outcomes After Endoscopic Sinus Surgery for Unilateral Sphenoid Sinusitis: A Multi‐Institutional Study
Authors: Eide Jacob G. , Pellizzari Richard , Saibene Alberto M. , De Donato Luigi , Bitner Benjamin , Wei Kimberly , Panara Kush , Kshirsagar Rijul , Lee Daniel , Douglas Jennifer E. , Whitehead Russell , Filip Peter , Papagiannopoulos Peter , Tajudeen Bobby , Kuan Edward C. , Adappa Nithin D. , Palmer James N. , Craig John R. 
Published: January 2025

IntroductionUnilateral sphenoid sinus opacification on computed tomography is caused by a variety of pathologies including inflammatory and infectious sinusitis, benign and malignant tumors, and encephaloceles. The purpose of this study was to report craniofacial pain locations and outcomes in inflammatory unilateral sphenoid sinusitis (USS) patients who underwent endoscopic sinus surgery (ESS).MethodsA multi‐institutional retrospective cohort study was conducted on all adult patients who had ESS for USS from 2015 to 2022. Patient demographics, presenting symptoms and nasal endoscopy findings, extent of surgical dissection, and craniofacial pain locations and outcomes were recorded. Exclusion criteria included age <18 years, non‐inflammatory etiology, immunodeficiency, invasive fungal sinusitis, lack of follow‐up, lack of preoperative pain location, and neoplasia. Descriptive statistics were calculated.ResultsOf 57 patients with USS, 44 (77.2%) reported craniofacial pain at one or more locations. Retrobulbar (n = 19, 43.2%) was the most common pain location followed by frontal (n = 17, 38.6%) and occipital (n = 10, 22.7%). Surgical intervention resulted in pain resolution in 33/44 patients (75%), with a mean follow‐up of 83.7 (±97.8) days. There were no significant associations between presenting symptoms, imaging findings, endoscopy, surgical extent, or final pathology and the presence or resolution of facial pain (p > 0.05).ConclusionIn USS patients, the most common craniofacial pain locations were retrobulbar, occipital, and frontal, with a minority being vertex. Based on short‐term follow‐up, ESS resolved the craniofacial pain in 75% of cases. There were no clinical variables that predicted the presence or resolution of craniofacial pain.Level of EvidenceIV Laryngoscope, 2025