bluuebunny/crossref_metadata_2025_split huggingface dataset:
The loss of DLG2 isoform 7/8, but not isoform 2, is critical in advanced staged neuroblastoma
Authors: Keane Simon , Martinsson Tommy , Kogner Per , Ejeskar Katarina 
Published: February 2021

Abstract
BACKGROUND:Neuroblastoma is a childhood neural crest tumor showing large clinical and genetic heterogeneity, one form displaying 11q-deletion is very aggressive. It has been shown that 11q-deletion results in decreased expression of DLG2, a gene residing in the deleted region. DLG2 has a number of different isoforms with the main difference is the presence or absence of a L27 domain. The L27 domain containing DLG proteins can form complexes with CASK/MPP and LIN7 protein family members, which will control cell polarity and signaling. METHODS:We evaluated the DLG gene family and the LIN7 gene family for their expression in differently INSS staged neuroblastoma from publically available data and primary tumors, we included two distinct DLG1 and DLG2 N-terminal transcript isoforms encoding L27 domains for their expression. Functionality of DLG2 isoforms and of LIN7A were evaluated in the 11q-deleted neuroblastoma cell line SKNAS.RESULTS:In neuroblastoma only two DLG2 isoforms were expressed: isoform 2 and isoform 7/8. Using the array data we could determine that higher expression of DLG members that contain L27 domains correlated to better survival and prognosis. Whilst DLG1 showed a decrease in both isoforms with increased INSS stage, only the full length L27 containing DLG2 transcripts DLG2-isoform 7/8 showed a decrease in expression in high stage neuroblastoma. We could show that the protein encoded by DLG2-isoform 7 could bind to LIN7A, and increased DLG2-isoform 7 gene expression increased the expression of LIN7A, this reduced neuroblastoma cell proliferation and viability, with increased BAX/BCL2 ratio indicating increased apoptosis.CONCLUSION:We have provided evidence that gene expression of the L27 domain containing DLG2-isoform 7/8 but not L27 domain lacking DLG2-isoform 2 is disrupted in neuroblastoma, in particular in the aggressive subsets of tumors. The presence of the complete L27 domain allows for the binding to LIN7A, which will control cell polarity and signaling, thus affecting cancer cell viability.
Prognostic and predictive value of FCER1G in glioma outcomes and response to immunotherapy
Authors: Xu Houshi , Zhu Qingwei , Tang Lan , Jiang Junkun , Yuan Huiwen , Zhang Anke , Lou Meiqing 
Published: February 2021

Abstract
Purpose: Glioma is the most prevalent malignant form of brain tumors, with a dismal prognosis. Currently, cancer immunotherapy has emerged as a revolutionary treatment for patients with advanced highly aggressive therapy-resistant tumors. However, there is no effective biomarker to reflect the response to immunotherapy in glioma patient so far. So we aim to assess the clinical predictive value of FCER1G in patients with glioma. Methods: The expression level and correlation between clinical prognosis and FER1G levels were analyzed with the data from CGGA, TCGA, and GEO database. Univariate and multivariate cox regression model was built to predict the prognosis of glioma patients with multiple factors. Then the correlation between FCER1G with immune cell infiltration and activation was analyzed. At last, we predict the immunotherapeutic response in both high and low FCER1G expression subgroups.Results: FCER1G was significantly higher in glioma with greater malignancy and predicted poor prognosis. In multivariate analysis, the hazard ratio of FCER1G expression (Low versus High) was 0.66 and 95% CI is 0.54 to 0.79 (P <0.001), whereas age (HR=1.26, 95% CI=1.04-1.52), grade (HR=2.75, 95% CI=2.06-3.68), tumor recurrence (HR=2.17, 95% CI=1.81-2.62), IDH mutant (HR=2.46, 95% CI=1.97-3.01) and chemotherapeutic status (HR=1.4, 95% CI=1.20-1.80) are also included. Furthermore, we illustrated that gene FCER1G stratified glioma cases into high and low FCER1G expression subgroups that demonstrated with distinct clinical outcomes and T cell activation. At last, we demonstrated that high FCER1G levels presented great immunotherapeutic response in glioma patients.Conclusions: This study demonstrated FCER1G as a novel predictor for clinical diagnosis, prognosis, and response to immunotherapy in glioma patient. Assess expression of FCER1G is a promising method to discover patients that may benefit from immunotherapy.
STUDY OF THE EFFICIENCY OF SQUEEZING MOISTURE-SATURATED PRODUCTS
Authors: Bahadirov Gayrat , Tsoy Gerasim , Nabiev Ayder 
Published: February 2021

The leather industry includes many technological machines; a squeezing roller machine is used in many operations, for example, in squeezing, degreasing, and after drum dyeing of a semi-finished leather product.
The paper presents the results of experimental studies obtained by determining the influence of multilayer wet leather semi-finished products with monshons under squeezing on the amount of the moisture extracted. Mathematical dependences of the amount of the moisture extracted, for each layer of a five-layer wet leather semi-finished product on the feed rate between the squeeze rollers and the roller pressure were obtained.
Experimental research is of scientific and practical importance for the development of a technological process for extracting moisture from wet leather semi-finished products used in the tannery, since the quality of the extraction affects the quality of subsequent technological operations, such as leather shaping and splitting.
An experimental study was performed using the method of mathematical statistics, namely, the method of mathematical planning of the experiment.
Mathematical models were obtained for the amount of extracted moisture from five wet leather semi-finished products depending on the rate of their simultaneous feed and the pressure of the squeezing rollers.
The results of the experiment showed that in squeezing a five-layer product, the productivity of the technological process of extracting moisture from wet leather semi-finished products increases by five times in comparison with existing squeezing roller machines.
The use of the results of the experimental study will contribute to a significant reduction in the energy consumption of the squeezing roller machine by simultaneous multi-layer processing of wet leather semi-finished products
REVIEW: COMPARISON OF ULTRASONICALLY AIDED ZINC BENEFICIATION BY MECHANICAL FLOTATION AND COLUMN FLOTATION CELL
Authors: Ulusoy Ugur , Kurşun Hulya 
Published: February 2021

Zinc is a key beneficiary of economic development for the developing countries. While the global zinc mine production in 2019 was recorded as 13 million tons, the value of zinc mined in 2019, based on zinc contained in concentrate, was about $2.1 billion. Sphalerite or zinc blende (ZnS), which is the main source of zinc, provides more than 90 % of zinc productions today. Beneficiation is usually carried out by flotation to produce marketable concentrates (45–55 %Zn). The flotation, which is the most widely used separation process at fine sizes for the concentration of low grade complex Pb-Cu-Zn ores plays an important role in the global economy. In any concentration plant employing flotation technique huge quantity of ores are being processed. Thus, any increments in the flotation recovery are important to get higher profits and to ensure that resources are utilized optimally. In this review, a comparative evaluation was made between mechanical flotation (MF) [1] and column (CF) [2] cells with or without ultrasonic pre-treatment (UP) for zinc recovery from lead-zinc-copper ore and the effect of UP on the MF and CF experiments were investigated at the optimized conditions. When compared with the optimized parameters, UP increased zinc grade and recovery for both MF and CF techniques as supported by XRD patterns. Besides, the best zinc grade and recovery was obtained by UP with CF technique. So that, sphalerite mineral can be effectively beneficiated to produce saleable zinc concentrate product and UP with CF will lead to a higher metallurgical gains and improvements to Net Smelter Return (NSR). This positive effect of ultrasound, which is safe and eco-friendly, on the zinc flotation by both mechanical cell and column cell regarding zinc grade and recovery is in good agreement with the previous published works in the literature
A RESEARCH ON MULTI-OBJECTIVE OPTIMIZATION OF THE GRINDING PROCESS USING SEGMENTED GRINDING WHEEL BY TAGUCHI-DEAR METHOD
Authors: Trung Do Duc , Nguyen Nhu-Tung , Tien Dung Hoang , Dang Ha Le 
Published: February 2021

In this study, the mutil-objective optimization was applied for the surface grinding process of SAE420 steel. The aluminum oxide grinding wheels that were grooved by 15 grooves, 18 grooves, and 20 grooves were used in the experimental process. The Taguchi method was applied to design the experimental matrix. Four input parameters that were chosen for each experiment were the number of grooves in cylinder surface of grinding wheel, workpiece velocity, feed rate, and cutting depth. Four output parameters that were measured for each experimental were the machining surface roughness, the system vibrations in the three directions (X, Y, Z). The DEAR technique was applied to determine the values of the input parameters to obtaine the minimum values of machining surface roughness and vibrations in three directions. By using this technique, the optimum values of grinding wheel groove number, workpiece velocity, feed-rate, cutting depth were 18 grooves, 15 m/min, 2 mm/stroke, and 0.005 mm, respectively. The verified experimental was performed by using the optimum values of input parameters. The validation results of surface roughness and vibrations in X, Y, Z directions were 0.826 (µm), 0.531 (µm), 0.549 (µm), and 0. 646 (µm), respectively. These results were great improved in comparing to the normal experimental results. Taguchi method and DEAR technique can be applied to improve the quality of grinding surface and reduce the vibrations of the technology system to restrain the increasing of the cutting forces in the grinding process. Finally, the research direction was also proposed in this study
Traditional and Perspective Methods of Corporate Non-Performing Loans Rejustment (Liquidation)
Authors: Poletaeva V. M. , Smulov A. M. 
Published: February 2021

Article covers issues of banks’ corporate non-performing and overdue loans management (liquidation). Authors make revision of methods that banks usually use for current goal solution and develop concepts of approaches to non-performing loans management that could become out the perspective alternative for traditional methods. Scientific novelty of the manuscript is in developing the methods (modifications of methods) of bank corporate nonperforming loans rejustment (liquidation). The principle of the first method is in changing conditions of corporate debt repayment - the new conditions must be determined by financial possibilities of the borrower. The main idea of the second one is in non-performing or overdue debt sell on the quasiequivalent terms. At that article set the modification of the second method, based on the idea of the expansion of the list of types of securities used for nonperforming loans exchange deals and provides with the substantiation of the author's position. In addition, the manuscript presents algorithms of mentioned perspective methods implementation. Article is based on the studies of leading Russian economists in the field of national economic system growth, banking, corporate non-performing loans management.
Family Psychoeducation Increases the Role of Families in Caring for People with Mental Disorders
Authors: Dwi Jayanti Desak Made Ari , Lestari Ni Kadek Yuni 
Published: February 2021

<p><em>Family psychoeducation is a family therapy that combines clinical interventions to increase family understanding in order to improve the health of people with mental disorders. The purpose of this study<strong> </strong>was to determine the effect of family psychoeducation on the role of the family caring for people with mental disorders. This study used a Quasi Experiment design: pre-test and post-test Control Group Design. The sample was taken by using purposive sampling. The sample was 20 people in the control group and 20 people in the treatment group. The analysis test used was the Wilcoxon sign test (intra-group) and the Mann Whitney (inter-group) test. The intra-group analysis test in the pre and post-test for the control group obtained p value = 0.517 which means there is no difference, while the treatment group obtained p value = 0.004 which means there is a difference. Inter-group analysis test of the treatment group and the control group obtained p value = 0.008, which means that there is an effect of family psychoeducation on the role of families in caring for people with mental disorders. Family psychoeducation can be applied to families with mentally disorders people.</em></p>
Physical environments of water containers and Aedes sp larvae in dengue endemic areas of Tanjungpinang Timur District
Authors: Daswito Rinaldi , Samosir Kholilah 
Published: February 2021

Purpose: This study aimed to determine the relationship of the container environment's type and condition to the existence of Aedes sp larvae in Tanjungpinang Timur District. Methods: An observational study with a cross-sectional approach involved 401 houses with containers in Tanjungpinang Timur District, Tanjungpinang City. Data on the existence of larvae was performed using the single larvae method. Data on container type and container environmental conditions (water pH, water temperature, air temperature, air humidity) and larvae's presence were collected by observing and measuring. Results: 863 containers were observed, 138 of them (15.99%) were found larvae of Aedes sp, containers inside the house (65.57%), and not closed (88.53%). The types of containers were controllable sites (95.13%), disposable sites (3.36%), and under controllable sites (1.51%). The measurement of water pH (76.13%) and water temperature (82.73%) of the containers were categorized as good. Container temperature 98.38% showed results with a range of unfavorable conditions (<200C &> 300C) and air humidity of 99.07% with a range (<81.5% &> 89.5%). Type, location, condition of container closure, water pH, water temperature, and air temperature of containers were related to larvae in Tanjungpinang Timur District (p-value <0.05), while the variable humidity was not related to the existence of larvae. Conclusion: Physical environmental factors strongly support the reproduction of DHF vectors in the East Tanjungpinang District. It is necessary to increase public knowledge and routine home eradication of mosquito nests (PSN), especially controllable site containers widely used as water reservoirs.
SOLIDARITY DURING COVID-19 PANDEMIC ( A CASE STUDY ON THE SOCIAL ACTION OF YOGYAKARTA FOOD SOLIDARITY AND THE INTERFAITH NETWORK FOR COVID-19 RESPONSE)
Authors: Haryadi Didid , Malitasari Devira Nur 
Published: February 2021

Reality pandemic Covid-19 has a significant impact on the social, economic, political, and cultures around the world. Covid-19 which hit Indonesia has brought organic collective awareness from civilians through social movements. Initiatives from citizens to help one another are based on three things; the existence of a collective identity, a sense of injustice, and solidarity. This research focuses on two social movements initiated by ‘Solidaritas Pangan Jogja’ (SPJ) and ‘Jaringan Lintas Iman Tanggap Covid-19’ (JIC). The basic principles of mutual assistance, spontaneous collective awareness, and the same social needs form a pattern of solidarity and social movement in these two organizations. Therefore, this research focuses on the process of forming social awareness patterns that are manifested through collective behavior. This research uses a qualitative approach through case studies. Social solidarity and social movements are two concepts that are used as a basis for data analysis. There are two differences between the SPJ and JIC movement patterns. This research uses a qualitative approach through case studies. Social solidarity and social movements are two concepts that are used as a basis for data analysis. There are two differences between the SPJ and JIC movement patterns. The SPJ movement can be categorized as a conventional social movement with an orientation towards creating collective and cross-class social awareness. Whereas the JIC movement is a kind of new social movement which using the basics of the collectivity to understand norms and religious values. While the similarity of the two movements is always to prioritize the distribution of human values that are sustainable. The determining factor for the formation of a collective movement depends not only on the material resources available, but rather on the strength of ideas and cultural resources. That is about the articulation and collective construction of a new relationship (or redefinition) between the person as an individual and the person (as an ulama or cleric, citizen, and family). The SPJ movement carries the value of nativism while the JIC movement is a representation of the growth of new social movements that arise because of the spread of religious values in the social, cultural, economic, and political dimensions as citizens.Keywords: Pandemic Covid-19, Solidaritas Pangan Jogja (SPJ), Jaringan Lintas Iman Tanggap Covid-19 (JIC), Social Capital, Social Movement
Instilling Akhlakul Karimah through Islamic Education Learning (PAI) (Phenomenological Study at Senior High School)
Authors: Sugianto Hendi , Djamaluddin Mawardi 
Published: February 2021

This article discusses the guidance of akhlak karimah through PAI learning at Tunas Luhur Paiton Probolinggo High School. This article uses the Type of Field Research (Field Research) of the object of study by using reference sources on related topics. This article argues that the development of moral mercy through PAI learning in Tunas Luhur High School Paiton Probolinggo is a model of applying moral mercy which has implications for increasing students' submission to Allah SWT and improving the academic quality of students. This school is located in Paiton Probolinggo, which was established by PT. YTL East Java and PT. Java Power as a form of Community Development commitment. This school has many enthusiasts but is limited to a maximum of 20-30 students/classes. This school implements a Full Day School system in collaboration with the Institute of Probolinggo Regency and the Malang Institute of Development. The Tartila Institute of Probolinggo Regency organizes Qur'an Learning in addition to organizing English education in the form of smart English (s.e) so that a program of increasing devotion to Allah SWT relating to Requiring students to perform Dhuha Prayers, Dhuhr Congregational Prayers and Asr in schools and carry out a serial telephone to wake up students at night with the aim that students perform Tahajjud prayers; program The school's academic quality improvement program organizes the Student Learning Development Program (BBS) which has 2 objectives: UNAS success and SNMPTN success and Scientific Writing (KTI) which must be completed by students before semester 2 of the last class (TA). This article discusses the general description of the daily morals of students at Tunas Luhur Paiton Probolinggo High School which is implemented through the efforts made by PAI teachers in fostering student morals through PAI learning. The success of this school is characterized by behavior when at home even without control from the teacher, students still carry out routine worship that is accustomed to being carried out for example prayer in congregation and from the teacher, students continue to carry out routine worship that is accustomed to being carried out so that silaturrahmi formed both among students.
Novel three-dimensional methods to analyze the morphology of the nasal cavity and pharyngeal airway
Authors: Niu Xiaowen , Madhan Sivaranjani , Cornelis Marie A. , Cattaneo Paolo M. 
Published: February 2021

ABSTRACT

Objectives
To assess the intraexaminer and interexaminer reliabilities of novel semiautomatic methods to segment the nasal cavity (NC) and pharyngeal airway (PA) and to determine the minimal cross-sectional area (CS) and hydraulic diameter (HD) of the PA.

Materials and Methods
To test reproducibility, two examiners analyzed the NC and PA independently in 10 retrospectively selected cone beam computed tomography (CBCT) images using semiautomatic segmentation. The PA centerline was determined to assess the minimal CS and HD. The intraclass correlation coefficient (ICC) was used to calculate intraexaminer and interexaminer reliabilities. Measurement errors were assessed by Dahlberg's formula and paired t-tests. The level of agreement was assessed using the Bland-Altman method.

Results
Intraexaminer and interexaminer reliabilities were excellent (minimal ICC, 0.960). The error of the method was good except for interexaminer values for the oropharynx (P = .016). The minimal CS and HD measurements were reliable (minimal ICC, 0.993; narrow limits of agreement).

Conclusions
The novel methods for analysis of the NC and PA are reliable. The minimal CS and HD demonstrated excellent reliabilities, which are critical to detect the most constricted part of the PA. Separation of the oropharynx from the voids close to the retroglossal area is not trivial and should be considered with caution.
Liraglutide Increases the Catabolism of Apolipoprotein B100–Containing Lipoproteins in Patients With Type 2 Diabetes and Reduces Proprotein Convertase Subtilisin/Kexin Type 9 Expression
Authors: Vergès Bruno , Duvillard Laurence , Pais de Barros Jean Paul , Bouillet Benjamin , Baillot-Rudoni Sabine , Rouland Alexia , Petit Jean Michel , Degrace Pascal , Demizieux Laurent 
Published: February 2021

OBJECTIVE
Dyslipidemia observed in type 2 diabetes (T2D) is atherogenic. Important features of diabetic dyslipidemia are increased levels of triglyceride-rich lipoproteins and small dense LDL particles, which all have apolipoprotein B100 (apoB100) as a major apolipoprotein. This prompted us to study the effect of the GLP-1 agonist liraglutide on the metabolism of apoB100-containing lipoproteins.

RESEARCH DESIGN AND METHODS
We performed an in vivo kinetic study with stable isotopes (L-[1-13C]leucine) in 10 patients with T2D before and after 6 months of treatment with liraglutide (1.2 mg/day). We also evaluated in mice the effect of liraglutide on the expression of genes involved in apoB100-containing lipoprotein clearance.

RESULTS
In patients with T2D, liraglutide treatment significantly reduced plasma apoB100 (0.93 ± 0.13 vs. 1.09 ± 0.11 g/L, P = 0.011) and fasting triglycerides (1.76 ± 0.37 vs. 2.48 ± 0.69 mmol/L, P = 0.005). The kinetic study showed a significant increase in indirect catabolism of VLDL1-apoB100 (4.11 ± 1.91 vs. 2.96 ± 1.61 pools/day, P = 0.005), VLDL2-apoB100 (5.17 ± 2.53 vs. 2.84 ± 1.65 pools/day, P = 0.008), and IDL-apoB100 (5.27 ± 2.77 vs. 3.74 ± 1.85 pools/day, P = 0.017) and in catabolism of LDL-apoB100 (0.72 ± 0.22 vs. 0.56 ± 0.22 pools/day, P = 0.005). In mice, liraglutide increased lipoprotein lipase (LPL) gene expression and reduced proprotein convertase subtilisin/kexin type 9 (PCSK9), retinol-binding protein 4 (RBP4), and tumor necrosis factor-α (TNF-α) gene expression in adipose tissue and decreased PCSK9 mRNA and increased LDL receptor protein expression in liver. In vitro, liraglutide directly reduced the expression of PCSK9 in the liver.

CONCLUSIONS
Treatment with liraglutide induces a significant acceleration of the catabolism of triglyceride-rich lipoproteins (VLDL1, VLDL2, IDL) and LDL. Liraglutide modifies the expression of genes involved in apoB100-containing lipoprotein catabolism. These positive effects on lipoprotein metabolism may reduce cardiovascular risk in T2D.