bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal suicide attempts and deaths in the first year after cesarean delivery
Authors: Zhang Tianyang , Mantel Ängla , Runeson Bo , Sidorchuk Anna , Rück Christian , Stephansson Olof , Larsson Henrik , Chang Zheng , Mataix-Cols David , Fernández de la Cruz Lorena 
Published: December 2021

AbstractBackgroundCesarean delivery (CD) has been associated with postpartum psychiatric disorders, but less is known about the risk of suicidal behaviors. We estimated the incidence and risk of suicide attempts and deaths during the first postpartum year in mothers who delivered via CD v. vaginally.MethodAll deliveries in Sweden between 1973 and 2012 were identified. The mothers were followed since delivery for 12 months or until the date of one of the outcomes (i.e. suicide attempt or death by suicide), death by other causes or emigration. Associations were estimated using Cox proportional hazards regression models.ResultsOf 4 016 789 identified deliveries, 514 113 (12.8%) were CDs and 3 502 676 (87.2%) were vaginal deliveries. During the 12-month follow-up, 504 (0.098%) suicide attempts were observed in the CD group and 2240 (0.064%) in the vaginal delivery group (risk difference: 0.034%), while 11 (0.0037%) deaths by suicide were registered in the CD group and 109 (0.0029%) in the vaginal delivery group (risk difference: 0.008%). Compared to vaginal delivery, CD was associated with an increased risk of suicide attempts [hazard ratio (HR) 1.46; 95% CI 1.32–1.60], but not of deaths by suicide (HR 1.44; 95% CI 0.88–2.36).ConclusionsMaternal suicidal behaviors during the first postpartum year were uncommon in Sweden. Compared to vaginal delivery, CD was associated with a small increased risk of suicide attempts, but not death by suicide. Improved understanding of the association between CD and maternal suicidal behaviors may promote more appropriate measures to improve maternal mental well-being and further reduce suicidal risks.
EXPLORING THE RELATIONSHIP BETWEEN SECOND LANGUAGE LEARNING MOTIVATION AND PROFICIENCY
Authors: Dunn Karen , Iwaniec Janina 
Published: December 2021

AbstractA foundation of second language motivational theory has been that motivation contributes to explaining variance in language learning proficiency; however, empirical findings have been mixed. This article presents an innovative approach to exploring L2 proficiency and motivations of teenage English language learners in Madrid, Spain (N = 1773). Participants completed a multiskill English language test, plus an eight-scale questionnaire operationalizing constructs from Dörnyei’s L2 Motivational Self System (Dörnyei, 2005). Data were analysed using Latent Variable Mixture Modeling, a person-centered profiling approach. Results indicated five distinct classes of students, characterized by differing motivation-proficiency profiles. The importance of this study is that the analysis does not assume a homogenous relationship between motivational traits and proficiency levels across the learner sample; whilst there is undoubtedly a connection between the two areas, it is not a straightforward correlation, explaining to some extent discrepancies in previous findings and laying groundwork for further, more nuanced, investigation.
Interleukin-18 and COVID-19
Authors: Schooling C. M. , Li M. , Au Yeung S. L. 
Published: December 2021

Abstract
Vulnerability to coronavirus disease (COVID)-19 varies due to differences in interferon gamma (IFNγ) immunity. We investigated whether a key modifiable interferon precursor, interleukin-18, was related to COVID-19, overall and by severity, using Mendelian randomisation. We used four established genome-wide significant genetic predictors of interleukin-18 applied to the most recent genome-wide association study of COVID-19 (June 2021) to obtain Mendelian randomisation inverse variance weighted estimates by severity, i.e. any (cases = 112 612, non-cases = 2 474 079), hospitalised (cases = 24 274, non-cases = 2 061 529) and very severe (cases = 8779, non-cases = 1 001 875) COVID-19. To be comprehensive, we also conducted an exploratory analysis for IFNγ and two related cytokines with less well-established genetic predictors, i.e. interleukin-12 and interleukin-23. Genetically predicted interleukin-18 was associated with lower risk of any COVID-19 (odds ratio (OR) 0.96 per standard deviation, 95% confidence interval (0.94–0.99, P-value 0.004)) and of very severe COVID-19 (OR 0.88, 95% CI 0.78–0.999, P-value 0.048). Sensitivity analysis and a more liberal genetic instrument selection gave largely similar results. Few genome-wide significant genetic predictors were available for IFNγ, interleukin-12 or interleukin-23, and no associations with COVID-19 were evident. Interleukin-18 could be a modifiable target to prevent COVID-19 and should be further explored in an experimental design.
Double aortic arch: an elusive diagnosis in a child with CHD
Authors: Lemos Mariana , Fogaça da Mata Miguel , Coutinho Santos Ana 
Published: December 2021

AbstractAn 18-month-old male with pulmonary atresia and ventricular septal defect presented with stridor after neonatal systemic-to-pulmonary artery shunt surgery, that persisted on follow-up. CT angiography revealed a vascular ring with balanced double aortic arch.
Takotsubo syndrome as a cardiac manifestation of multisystem inflammatory syndrome in children
Authors: Ludwikowska Kamila M. , Tracewski Paweł , Kusa Jacek 
Published: December 2021

AbstractCases of severe heart damage in patients presenting with multisystem inflammatory syndrome in children are one of the most intriguing phenomena during the coronavirus disease of 2019 pandemic. The pathophysiology of myocardial changes in the course of this syndrome has not been fully understood yet. We present a case of a child with multisystem inflammatory syndrome in children and with cardiac changes corresponding to Takotsubo syndrome.
Henry Foe's dilemma
Authors: Ward Ian 
Published: December 2021

AbstractIn 1722, Daniel Defoe publishedA Journal of the Plague Year– a supposed account of the ‘great plague’ of 1665. It is commonly thought to be one of his most incisive pieces of ‘realist’ fiction. And, in our moment, one of his most prescient. The purpose of this paper is to revisit Defoe'sJournalin order to stimulate reflection on our present experience of living through the ‘plague year’ of 2020. There is much, as we shall see, about governance during a plague that is resonant – but much also about ‘hearts melted into tears’, about suffering, how it is felt and how it is perceived. The purpose of theJournal, according to Defoe at least, was to inform ‘those who come after’, so that they might be better prepared, so that they would not make the same mistakes. We will see.
Distinguishing the Explicit Power Motives
Authors: Schattke Kaspar , Marion-Jetten Ariane S. 
Published: December 2021

Abstract. Power is an important motivator at work, particularly for leaders. However, power also relates to dark personality traits, which negatively affect employees and organizations. Therefore, we argue that a high explicit power motive is a double-edged sword depending on whether people desire power for dominance, prestige, or leadership. We explored these research questions in a cross-sectional ( N = 151 employees) and a prospective study ( N = 371 leaders). Both studies revealed that dominance is most strongly related to Machiavellianism and moderately to narcissism and psychopathy. Prestige related strongly to narcissism and weakly to Machiavellianism, while leadership only weakly related to narcissism. Dominance best predicted counterproductive work behavior (CWB), while leadership best-predicted organizational citizenship behavior (OCB). In addition, Study 2 showed that transformational and, to a lesser extent, transactional leadership styles mediated the relations between the three power motives with OCB and CWB, respectively. Thus, promoting transformational leadership might be a fruitful way of channeling leaders’ power motives into pro-social actions.
Elevated EDAR signalling promotes mammary gland tumourigenesis with squamous metaplasia
Authors: Williams Rebecca , Jobling Stephanie , Sims Andrew H. , Mou Chunyan , Wilkinson Lorna , Collu Giovanna M. , Streuli Charles H. , Gilmore Andrew P. , Headon Denis J. , Brennan Keith 
Published: December 2021

AbstractEctodysplasin A receptor (EDAR) is a death receptor in the Tumour Necrosis Factor Receptor (TNFR) superfamily with roles in the development of hair follicles, teeth and cutaneous glands. Here we report that human Oestrogen Receptor (ER) negative breast carcinomas which display squamous differentiation express EDAR strongly. Using a mouse model with a high Edar copy number, we show that elevated EDAR signalling results in a high incidence of mammary tumours in breeding female mice. These tumours resemble the EDAR-high human tumours in that they are characterised by a lack of oestrogen receptor expression, contain extensive squamous metaplasia, and display strong β-catenin transcriptional activity. In the mouse model, all of the tumours carry somatic deletions of the third exon of the CTNNB1 gene that encodes β-catenin. Deletion of this exon yields unconstrained β-catenin signalling activity. We also demonstrate that β-catenin activity is required for transformed cell growth, showing that increased EDAR signalling creates an environment in which β-catenin activity can readily promote tumourigenesis. Together, this work identifies a novel death receptor oncogene in breast cancer, whose mechanism of transformation is based on the interaction between the WNT and Ectodysplasin A (EDA) pathways.
Induction of Rosette-to-Lumen stage embryoids using reprogramming paradigms in ESCs
Authors: Langkabel Jan , Horne Arik , Bonaguro Lorenzo , Holsten Lisa , Hesse Tatiana , Knaus Alexej , Riedel Yannick , Becker Matthias , Händler Kristian , Elmzzahi Tarek , Bassler Kevin , Reusch Nico , Yeghiazarian Leon Harootoonovtch , Pecht Tal , Saglam Adem , Ulas Thomas , Aschenbrenner Anna C. , Kaiser Franziska , Kubaczka Caroline , Schultze Joachim L. , Schorle Hubert 
Published: December 2021

AbstractBlastocyst-derived stem cell lines were shown to self-organize into embryo-like structures in 3D cell culture environments. Here, we provide evidence that embryo-like structures can be generated solely based on transcription factor-mediated reprogramming of embryonic stem cells in a simple 3D co-culture system. Embryonic stem cells in these cultures self-organize into elongated, compartmentalized embryo-like structures reflecting aspects of the inner regions of the early post-implantation embryo. Single-cell RNA-sequencing reveals transcriptional profiles resembling epiblast, primitive-/visceral endoderm, and extraembryonic ectoderm of early murine embryos around E4.5–E5.5. In this stem cell-based embryo model, progression from rosette formation to lumenogenesis accompanied by progression from naïve- to primed pluripotency was observed within Epi-like cells. Additionally, lineage specification of primordial germ cells and distal/anterior visceral endoderm-like cells was observed in epiblast- or visceral endoderm-like compartments, respectively. The system presented in this study allows for fast and reproducible generation of embryo-like structures, providing an additional tool to study aspects of early embryogenesis.
Specialising neural network potentials for accurate properties and application to the mechanical response of titanium
Authors: Wen Tongqi , Wang Rui , Zhu Lingyu , Zhang Linfeng , Wang Han , Srolovitz David J. , Wu Zhaoxuan 
Published: December 2021

AbstractLarge scale atomistic simulations provide direct access to important materials phenomena not easily accessible to experiments or quantum mechanics-based calculation approaches. Accurate and efficient interatomic potentials are the key enabler, but their development remains a challenge for complex materials and/or complex phenomena. Machine learning potentials, such as the Deep Potential (DP) approach, provide robust means to produce general purpose interatomic potentials. Here, we provide a methodology for specialising machine learning potentials for high fidelity simulations of complex phenomena, where general potentials do not suffice. As an example, we specialise a general purpose DP method to describe the mechanical response of two allotropes of titanium (in addition to other defect, thermodynamic and structural properties). The resulting DP correctly captures the structures, energies, elastic constants and γ-lines of Ti in both the HCP and BCC structures, as well as properties such as dislocation core structures, vacancy formation energies, phase transition temperatures, and thermal expansion. The DP thus enables direct atomistic modelling of plastic and fracture behaviour of Ti. The approach to specialising DP interatomic potential, DPspecX, for accurate reproduction of properties of interest “X”, is general and extensible to other systems and properties.
Contributions of sex, depression, and cognition on brain connectivity dynamics in Parkinson’s disease
Authors: Diez-Cirarda Maria , Gabilondo Iñigo , Ibarretxe-Bilbao Naroa , Gómez-Esteban Juan Carlos , Kim Jinhee , Lucas-Jiménez Olaia , Del Pino Rocio , Peña Javier , Ojeda Natalia , Mihaescu Alexander , Valli Mikaeel , Acera Maria Angeles , Cabrera-Zubizarreta Alberto , Gómez-Beldarrain Maria Angeles , Strafella Antonio P. 
Published: December 2021

AbstractAlterations in time-varying functional connectivity (FC) have been found in Parkinson’s disease (PD) patients. To date, very little is known about the influence of sex on brain FC in PD patients and how this could be related to disease severity. The first objective was to evaluate the influence of sex on dynamic FC characteristics in PD patients and healthy controls (HC), while the second aim was to investigate the temporal patterns of dynamic connectivity related to PD motor and non-motor symptoms. Ninety-nine PD patients and sixty-two HC underwent a neuropsychological and clinical assessment. Rs-fMRI and T1-weighted MRI were also acquired. Dynamic FC analyses were performed in the GIFT toolbox. Dynamic FC analyses identified two States: State I, characterized by within-network positive coupling; and State II that showed between-network connectivity, mostly involving somatomotor and visual networks. Sex differences were found in dynamic indexes in HC but these differences were not observed in PD. Hierarchical clustering analysis identified three phenotypically distinct PD subgroups: (1) Subgroup A was characterized by mild motor symptoms; (2) Subgroup B was characterized by depressive and motor symptoms; (3) Subgroup C was characterized by cognitive and motor symptoms. Results revealed that changes in the temporal properties of connectivity were related to the motor/non-motor outcomes of PD severity. Findings suggest that while in HC sex differences may play a certain role in dynamic connectivity patterns, in PD patients, these effects may be overcome by the neurodegenerative process. Changes in the temporal properties of connectivity in PD were mainly related to the clinical markers of PD severity.
Dopamine Neuron Challenge Test for early detection of Parkinson’s disease
Authors: Zhou Jingheng , Li Jicheng , Papaneri Amy B. , Kobzar Nicholas P. , Cui Guohong 
Published: December 2021

AbstractDiagnosing Parkinson’s disease (PD) before the clinical onset proves difficult because the hallmark PD symptoms do not manifest until more than 60% of dopamine neurons in the substantia nigra pars compacta have been lost. Here we show that, by evoking a transient dopamine release and subsequently measuring the levels of dopamine metabolites in the cerebrospinal fluid and plasma, a hypodopaminergic state can be revealed when less than 30% of dopamine neurons are lost in mouse PD models. These findings may lead to sensitive and practical screening and diagnostic tests for detecting early PD in the high-risk population.
Deep eutectic solvents for antiepileptic drug phenytoin solubilization: thermodynamic study
Authors: Shekaari Hemayat , Zafarani-Moattar Mohammed Taghi , Mokhtarpour Masumeh , Faraji Saeid 
Published: December 2021

AbstractThermodynamic investigations provide information about the solute-solvent interactions in the selection of the proper solvent for different fields of pharmaceutical sciences. Especially, the study of antiepileptic drugs in solutions (ethanol/co-solvent) has been a subject of interest owing to their effect in the systems using interaction with a number of important biological membranes. This work focuses on the measurement of density and speed of sound of the phenytoin (PTH) in ethanol/deep eutectic solvents (choline chloride:ethylene glycol, and choline chloride:glycerol) solutions as the innovative class of green solvents at temperature range (288.15 to 318.15) K. It was determined Hansen solubility parameters for assessment of PTH interactions in the solvent media. Some thermophysical parameters including apparent molar volumes Vϕ, apparent molar isobaric expansion $$E_\varphi^0$$

E
φ
0

, and Hepler’s constant, apparent molar isentropic compressibility κφ were obtained and calculated using these data. To correlate the Vϕ and κφ values, the Redlich-Meyer equation was used to calculate the number of quantities containing standard partial molar volume and partial molar isentropic compressibility. Finally, $$\Delta \delta$$

Δ
δ

values showed a strong interaction between PTH and solvent (ethanol/DES (ChCl:EG)). The thermodynamic analysis of the studied system also plays a crucial role in the pharmaceutical industry.
Effective method of monitoring cerebral tissue oxygen saturation in cardiac surgery patients by combined use of tNIRS-1 and bispectral index
Authors: Sugiura A. , Torii K. , Tsutsumi H. , Someya T. , Yasuoka D. , Nishikiori K. , Kitahara D. , Kakinuma H. 
Published: December 2021

AbstractTo continuously and noninvasively monitor the cerebral tissue oxygen saturation (StO2) and hemoglobin concentration (gasHb) in cardiac surgery patients, a method combining the use of a cerebral tissue oximeter using near infrared time-resolved spectroscopy (tNIRS-1) and the bispectral index (BIS) was developed in this study. Moreover, the correlation between the estimated hemoglobin concentration (estHb), measured via tNIRS-1, and the hemoglobin concentration (gasHb), analyzed using a blood gas analyzer, were compared. The relationship between the BIS and gasHb was also examined. Through the comparison of BIS and StO2 (r1), and estHb and gasHb (r2), the correlation between the two was clarified with maximum r1 and r2 values of 0.617 and 0.946, respectively. The relationship between BIS and gasHb (r3), showed that there was a favorable correlation with a maximum r3 value of 0.969. There was also a continuous correlation between BIS and StO2 in patients undergoing cardiac surgery. In addition, a strong correlation was found between estHb and gasHb, and between BIS and gasHb. It was therefore concluded that the combined use of BIS and tNIRS-1 is useful to evaluate cerebral hypoxia, allowing for quick response to cerebral hypoxia and reduction of hemoglobin concentration during the operation.
Activation of efficient DNA repair mechanisms after photon and proton irradiation of human chondrosarcoma cells
Authors: Lohberger Birgit , Glänzer Dietmar , Eck Nicole , Kerschbaum-Gruber Sylvia , Mara Elisabeth , Deycmar Simon , Madl Tobias , Kashofer Karl , Georg Petra , Leithner Andreas , Georg Dietmar 
Published: December 2021

AbstractAlthough particle therapy with protons has proven to be beneficial in the treatment of chondrosarcoma compared to photon-based (X-ray) radiation therapy, the cellular and molecular mechanisms have not yet been sufficiently investigated. Cell viability and colony forming ability were analyzed after X-ray and proton irradiation (IR). Cell cycle was analyzed using flow cytometry and corresponding regulator genes and key players of the DNA repair mechanisms were measured using next generation sequencing, protein expression and immunofluorescence staining. Changes in metabolic phenotypes were determined with nuclear magnetic resonance spectroscopy. Both X-ray and proton IR resulted in reduced cell survival and a G2/M phase arrest of the cell cycle. Especially 1 h after IR, a significant dose-dependent increase of phosphorylated γH2AX foci was observed. This was accompanied with a reprogramming in cellular metabolism. Interestingly, within 24 h the majority of clearly visible DNA damages were repaired and the metabolic phenotype restored. Involved DNA repair mechanisms are, besides the homology directed repair (HDR) and the non-homologous end-joining (NHEJ), especially the mismatch mediated repair (MMR) pathway with the key players EXO1, MSH3, and PCNA. Chondrosarcoma cells regenerates the majority of DNA damages within 24 h. These molecular mechanisms represent an important basis for an improved therapy.
Passivation of miniature microwave coplanar waveguides using a thin film fluoropolymer electret
Authors: Marzouk Jaouad , Avramovic Vanessa , Guérin David , Arscott Steve 
Published: December 2021

AbstractThe insertion losses of miniature gold/silicon-on-insulator (SOI) coplanar waveguides (CPW) are rendered low, stable, and light insensitive when covered with a thin film (95 nm) fluoropolymer deposited by a trifluoromethane (CHF3) plasma. Microwave characterization (0–50 GHz) of the CPWs indicates that the fluoropolymer stabilizes a hydrogen-passivated silicon surface between the CPW tracks. The hydrophobic nature of the fluoropolymer acts as a humidity barrier, meaning that the underlying intertrack silicon surfaces do not re-oxidize over time—something that is known to increase losses. In addition, the fluoropolymer thin film also renders the CPW insertion losses insensitive to illumination with white light (2400 lx)—something potentially advantageous when using optical microscopy observations during microwave measurements. Capacitance–voltage (CV) measurements of gold/fluoropolymer/silicon metal–insulator-semiconductor (MIS) capacitors indicate that the fluoropolymer is an electret—storing positive charge. The experimental results suggest that the stored positive charge in the fluoropolymer electret and charge trapping influence surface-associated losses in CPW—MIS device modelling supports this. Finally, and on a practical note, the thin fluoropolymer film is easily pierced by commercial microwave probes and does not adhere to them—facilitating the repeatable and reproducible characterization of microwave electronic circuitry passivated by thin fluoropolymer.
Two-dimensional layered MSi2N4 (M = Mo, W) as promising thermal management materials: a comparative study
Authors: Shen Chen , Wang Lei , Wei Donghai , Zhang Yixuan , Qin Guangzhao , Chen Xing-Qiu , Zhang Hongbin 
Published: December 2021

Two-dimensional layered MSi2N4 (M = Mo, W) as promising thermal management materials: a comparative study.