bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPLEMENTATION OF AN INTEGRATED MODEL OF CARING TO PATIENTS WITH ACUTE CEREBRAL CIRCULATION DISORDER
Authors: Дюсембаева Ж.Б. , Сраилова К.Б. , Раимкулов Б.Н. , Умутбаева Г.А. , Каримов Г.К. , Антонюк О.А. , Азимбаев Ш.Ш. 
Published: December 2021

Всемирная федерация неврологических обществ, ежегодно в мире регистрирует не менее 15-17 млн. различных видов инсультов[1-3]. По данным ВОЗ на 2018 год летальность от инсульта превысила 8,5 млн. человек. Эти данные являются относительными, так как регистрируются не все случаи заболеваемости, или инсульты протекают под маской других заболеваний. Заболеваемость инсультом значительно варьирует в различных регионах - от 1 до 5-8 случаев на 1000 населения в год. Невысокую заболеваемость отмечают в странах Северной и Центральной Европы (0,38-0,47 на 1000 населения), высокую - в Восточной Европе, что связано прежде всего с профилактическими мероприятиями в медицине. В Российской Федерации заболеваемость инсультом среди лиц старше 25 лет составила 3,48±O,21, смертность от инсульта - l,17±О,06 на 1000 населения в год [4-5]. В США частота инсульта среди жителей европеоидной расы составляет 1,38-1,67 на 1000 населения. В Республике Казахстан ведется регистр заболеваемости инсультов на базе ряда лечебных учреждений г. Алматы [6-10]. Интегрированная модель оказания медицинской помощи по основным социально значимым выше перечисленным, неинфекционным заболеваниям и заболеваниям, существенно влияющим на демографию населения страны позволит обеспечит оказание комплексных медицинских и социальных услуг человеку на протяжении всего жизненного цикла для предупреждения, своевременного выявления и снижения риска развития осложнений заболевания с целью увеличения продолжительности жизни и обеспечит дальнейшую регионализацию оказания медицинской помощи населению РК. Ученые из научно-исследовательских центров окажут необходимую консультативную, методическую и практическую помощь медицинским работникам в регионах, вплоть до районного уровня по работе с населением страны. При этом услуги, требующие сложных технологических установок и специалистов с высокой квалификацией, будут централизованы на межрайонном, региональном, и республиканском уровнях. Услуги, для которых не нужны сложные технологические установки, будут оказываться в медорганизациях по месту жительства [12]. В данной статье отражены результаты исполнения Дорожной карты по внедрению интегрированной модели оказания помощи больным с ОНМК за 12 месяцев 2018 года в Городской клинической больнице №7 г. Алматы.
This article reflects the results of the implementation of the Roadmap for the implementation of an integrated model of care for patients with stroke for 12 months of 2018 in the City Clinical Hospital № 7 of Almaty.
TREATMENT OF NEWLY DIAGNOSED ACUTE PROMYELOCYTIC LEUKEMIA IN A PREGNANT WOMAN
Authors: Рамазанова Р.М. , Косанова А.К. , Шерияздан Ж.С. , Сабырбаева Г.А. , Жандыбаева Г.М. , Нураш Н.А. 
Published: December 2021

Описан клинический случай впервые выявленного острого промиелоцитарного лейкоза у 36-летней беременной женщины при сроке 16-17 нед. До родов ей проведены 2 курса химиотерапии по схеме AIDA: индукция ремиссии даунорубицин из расчета 60 мг/м - 2, 4, 6, 8 дни, АТRA 45мг/м с 1 по 15 дни, дексаметазон 2,5 мг/м х 2 р в день с 1- по 15 дни. Ремиссия достигнута после 1-го курса индукционной терапии. После завершения 2-го курса ХТ в периоде полной ремиссии острого промиелоцитарного лейкоза на сроке беременности 25 недель проведено кесарево сечение в условиях городского родильного дома. Через 2 нед после родоразрешения в условиях гематологического отделения проведены еще два курса консолидации ремиссии. Далее пациентка переведена на поддерживающую терапию согласно протоколу AIDA: АТRA 45мг/м с 1 по 15 дни каждые 3 месяца, Метотрексат 15 мг/м/сут еженедельно, 6-Меркаптопурин 50 мг/м/сут. В контрольных анализах миелограммы констатируется полная ремиссия - 2.5% бластных клеток при нормальном соотношении всех ростков кроветворения.
The case of de novo acute promyelocyte leukemia in a 36 year old pregnant woman (gestation age 16-17 weeks) is described. Two courses of “AIDA” chemotherapy were performed. Remission was achieved after the first induction chemotherapy. A month after the second consolidation chemotherapy at gestation age 25 weeks a living premature fetus was delivered by means of Cesarean delivery. After the delivery two more consolidation courses and supportive chemotherapy were performed. The woman now has been on remission.
ROLE AND PARTICIPATION OF THE MULTIDISCIPLINARY TEAM IN PROVIDING MEDICAL CARE TO PATIENTS WITH ACUTE CEREBRAL BLOOD CIRCULATION DISORDERS AT THE LEVEL OF A MULTIDISCIPLINARY HOSPITAL
Authors: Избасарова А.Ш. , Жиенбаева Б.С. , Дюсембаева Ж.Б. , Кокуров А.Л. , Ибрагимов М.М. , Аяганова Л.Б. , Бейсенбаева Г.Г. , Исмаилов А.К. , Избасарова А.С. 
Published: December 2021

Нами изучены и проанализированы годовые отчеты инсультных центров многопрофильных стационаров города Алматы с 2018 года по 2019 год включительно. За данный период было пролечено всего 8783 пациентов. Поступившие и пролеченные случаи инсульта были распределены по возрастному признаку в 2018 году (средний возраст составил 60,5±1,17 лет %) и половому признаку (мужчины - 46,6±6,4%, женщины - 53,3±6,4%). В 2019 году по возрасту было 61,30±5,8% пациентов, а по полу - 58,4±6,1% составляли женщины, а 41,5±6,1% - мужчины, следовательно, тенденция преобладание инсульта у женщин. Мультидисциплинарная бригада на уровне стационара в полном объеме выполняет свои функциональные обязанности, своевременно диагностируя вид инсульта, определяя тяжесть пациентов, перенесенные инсульт в остром периоде. Роль и место невролога при в мультидисциплинарной бригаде огромная и неоценима.
We have studied and analyzed the annual reports of stroke centers of multidisciplinary hospitals in the city of Almaty from 2018 to 2019 inclusive. During this period, a total of 8783 patients were treated. Stroke cases received and treated were distributed by age in 2018 (average age was 60.5 ± 1.17 years%) and gender (men - 46.6 ± 6.4%, women - 53.3 ± 6, 4%). In 2019, by age there were 61.30 ± 5.8% of patients, and by gender - 58.4 ± 6.1% were women, and 41.5 ± 6.1% were men, therefore, the trend is the prevalence of stroke in women. The multidisciplinary team at the hospital level fully fulfills its functional duties, diagnosing the type of stroke in a timely manner, determining the severity of patients suffering from a stroke in the acute period. The role and place of a neurologist in a multidisciplinary team is enormous and invaluable.
LUPUS NEPHRITE WITH FAST - PROGRESSING CURRENT: CASE REPORT
Authors: Султанова Б.Г. , Бодесова С.Б. , Ибрашева А.Т. , Мусабаев Б.С. , Бетирова Д.Ш. , Турлыхан Т.А. 
Published: December 2021

В статье описан «неклассический» случай, редко встречающаяся форма заболевания системной красной волчанкой без типичного поражения кожи с проявлением быстропрогрессирующего гломерулонефрита, с поражением тазобедренного сустава, выраженным болевым синдромом у юноши. С применением новых инновационных методов диагностики (непрямая иммунофлюоресценция на анализаторе AKLIDES), что позволило провести своевременно комплексную терапию включая в себя патогенетическую, эфферентную (гемодиализ, плазмаферез), тем самым получен хороший клинический эффект.
This article describes a non- racial case of systemic lupus erythematosus with the manifestation of a rapidly progressive glomerulonephritis, hip joint lesion, a pronounced painful syndrom, without dermal manifestations. By the use of new diagnostic methods (immunofluorescence), timely complex therapy: pathogenetic, efferent therapy, symptomatic therapy, it is possible to obtain a fairly good clinical - laboratory- instrumental result.
La Extensión Universitaria como herramienta de generación de políticas públicas para las personas con discapacidad
Authors: Matus Gómez Odderey José , Otero Escorcia César Alejandro , Conto Laínez Bertha María , Zamora Arrechavala Birmania 
Published: December 2021

Los problemas que afrontan las personas con discapacidad han sido considerados, a nivel internacional, como temas de mayor atención en los últimos tiempos. Las instituciones de educación superior, especialmente las de carácter público, han de tomar beligerancia en asumir estos desafíos a través de la función de Extensión, la cual debe convertirse en herramienta clave para la visibilización de estos problemas, especialmente con acciones formales como protocolos, campañas de sensibilización, y finalmente, la aprobación de políticas de extensión universitaria, a fin de generar propuestas sólidas que puedan llegar a convertirse en políticas públicas efectivas, que deban ser asumidas y promovidas por los respectivos Estados.
Habitar en tierra ajena: estudio sobre las condiciones de vida de mujeres migrantes venezolanas en Colombia
Authors: Bonilla Valencia Solange , Hernández Vásquez Sergio 
Published: December 2021

La migración venezolana es uno de los hechos migratorios más importantes en América Latina en la última década. Millones de personas salieron de Venezuela, siendo Colombia su principal destino. Esto significa un desafío para la integración, donde las mujeres han sido quienes han estado en una mayor condición de precariedad. Esta investigación tiene por objetivo determinar cómo han cambiado las condiciones de vida de las mujeres venezolanas migrantes en Colombia en el contexto de la pandemia. Este trabajo se realiza a partir de una metodología mixta que utiliza datos de la Gran Encuesta Integrada de Hogares, febrero y diciembre de 2020, el reporte GIFMM Colombia: Evaluación Conjunta de Necesidades ante Covid-19 de Junio del 2020, y entrevistas semiestructuradas a catorce mujeres en Bogotá, Medellín, Cali y Barranquilla. A partir de esta información se infiere que la condición migrante venezolana y de género son factores que condicionan fuertemente el acceso al empleo, salud y vivienda digna, siendo las mujeres en situación migratoria irregular las más afectadas antes y durante la pandemia. Además, que la dependencia a las redes de apoyo, los eventos de xenofobia y las afectaciones a la salud mental son aspectos clave para comprender las dificultades que experimentan las migrantes en la nueva normalidad.
Peran Keluarga terhadap Penurunan Tingkat Kecemasan Lanjut Usia
Authors: Cipta Utami Dewi Puspa 
Published: December 2021

Introduction: The role of the family is the specific behavior expected by someone in the family member. Anxiety is a fear that is not clear and is not supported by the situation.
Objective: To Know the Relationship of Family Role to the Level of Anxiety in the Elderly in Hamlet 01 Kukusan Beji-Depok
Method: The research method uses analytics with a cross-sectional approach. The study population was 288 people with a sample of 81 respondents using the Slovin formula. In the sampling technique using cluster sampling.
Results: The results showed that the respondents with a bad family role as many as 41 (50.6%) anxiety levels of the middle aged were 59 (72.8%). The results of statistical tests using the chi-square test indicate that there is a significant or significant relationship between the role of the family and the level of anxiety of the elderly with a value of p-value 0.01.
Conclusion: It was concluded that there was a relationship between the role of the family and the level of anxiety of the elderly in the Hamlet 01 Kukusan Beji District Depok City.
Integration of the former Panama Canal Zone into Metro Panama City
Authors: Uribe Alvaro 
Published: December 2021

The author, an architect-planner, Urbio, S.A., Panama, graduate of the School of Architecture, University of Panama, the Institut d'Urbanisme, University of Paris, and Institute for Housing and Urban Development Studies, Rotterdam, The Netherlands, has held key positions in a variety of public and private planning agencies as a consultant and specialist in Geographic Information Systems (G.I.S.) for major development projects in Panama such as Land Use and Traffic Study of the Port of Balboa; Development Plan for Sherman-San Lorenzo; La Cuenca Hidrográfica del Canal de Panamá: Posibilidades de un Desarrollo Sustentable (The Hydrographical Basin of the Panama Canal: Possibilities for Sustainable Development); Metodologías de Avalúo de los Terrenos Revertidos del Area del Canal (Methodologies for the Valuation of Reverted Land of the Area of the Canal); and Estudio Urbanístico y Demográfico del Area Metropolitana de Panamá (Urban and Demographic Study of the Metropolitan Regionof Panama). Alvaro Uribe has also published La Ciudad Fragmentada (The Fragmented City), an essay on urban development in Panama City (Panama City, CELA, Ediciones Formato Dieciséis, 1989), and a considerable number of papers and a study report on the subject of this paper and other related projects. He is a member of the World Society for Ekistics (WSE). The text that follows is a slightly edited and revised version of a paper presented at the WSE Symposion "Defining Success of the City in the 21st Century," Berlin, 24-28 October, 2001. It was kindly translated from the Spanish by Professor Lawrence D. Mann, also a member of the WSE and a participant at the Symposion.
EI-Nino southern oscillation and rainfall varIation over Bangladesh
Authors: AHMED A. S. M. SABBIR , MUNIM A. A. , BEGUM Q. N. , Choudhury A.M. 
Published: December 2021

In the present study, an attempt has been made to examine the variations of rainfall over Bangladesh and to find possible correlation with EI-Nino/Southern Oscillation (ENSO). Four stations have been chosen from four different climatic regions of Bangladesh for this purpose, namely Jessore, Dhaka. Barisal and Srimangal. The regions have been classified according to annual rainfall amounts. The rainfall data for forty three years, (1950-1992) have been analysed. The yearly mean rainfall shows a distinct negative decreasing tendency with the occurrence of ENSO.The seasonal rainfall analysis shows a somewhat better correlation.
In gesprek met Noortje de Boer
Authors: Merz Anna , Welp Pieter 
Published: December 2021

In gesprek met Noortje de Boer
In de serie ‘in gesprek met een pas gepromoveerde onderzoeker’ geven we aandacht aan promotieonderzoeken die voor toezichthouders relevant zijn. Hiervoor interviewen we als redactie van het Tijdschrift voor Toezicht (recent) gepromoveerde onderzoekers over hun onderzoek en de betekenis ervan voor het toezicht.In dit interview spraken Anna Merz en Pieter Welp, redacteuren van het Tijdschrift voor Toezicht, met Noortje de Boer die in 2020 promoveerde aan de Erasmus Universiteit Rotterdam op haar onderzoek naar het effect van transparantie op uitvoerende toezichthouders. Zij werkt momenteel bij de vakgroep Public Governance and Management aan de Universiteit Utrecht.
Sex-specific covariance between metabolic rate, behaviour and morphology in the ground beetle Carabus hortensis
Authors: Yarwood Elisabeth , Drees Claudia , Niven Jeremy E. , Schuett Wiebke 
Published: December 2021

Background
Individuals within the same species often differ in their metabolic rates, which may covary with behavioural traits (such as exploration), that are consistent across time and/or contexts, and morphological traits. Yet, despite the frequent occurrence of sexual dimorphisms in morphology and behaviour, few studies have assessed whether and how sexes differ in metabolic trait covariances.

Methods
We investigated sex-specific relationships among resting or active metabolic rate (RMR and AMR, respectively) with exploratory behaviour, measured independently of metabolic rate in a novel environment, body size and body mass, in Carabus hortensis ground beetles.

Results
RMR, AMR and exploratory behaviour were repeatable among individuals across time, except for male RMR which was unrepeatable. Female RMR neither correlated with exploratory behaviour nor body size/body mass. In contrast, AMR was correlated with both body size and exploratory behaviour. Males with larger body sizes had higher AMR, whereas females with larger body sizes had lower AMR. Both male and female AMR were significantly related to exploratory behaviour, though the relationships between AMR and exploration were body mass-dependent in males and temperature-dependent in females.

Discussion
Differences between sexes exist in the covariances between metabolic rate, body size and exploratory behaviour. This suggests that selection acts differently on males and females to produce these trait covariances with potentially important consequences for individual fitness.
The cnidarian parasite Ceratonova shasta utilizes inherited and recruited venom-like compounds during infection
Authors: Americus Benjamin , Hams Nicole , Klompen Anna M. L. , Alama-Bermejo Gema , Lotan Tamar , Bartholomew Jerri L. , Atkinson Stephen D. 
Published: December 2021

Background
Cnidarians are the most ancient venomous organisms. They store a cocktail of venom proteins inside unique stinging organelles called nematocysts. When a cnidarian encounters chemical and physical cues from a potential threat or prey animal, the nematocyst is triggered and fires a harpoon-like tubule to penetrate and inject venom into the prey. Nematocysts are present in all Cnidaria, including the morphologically simple Myxozoa, which are a speciose group of microscopic, spore-forming, obligate parasites of fish and invertebrates. Rather than predation or defense, myxozoans use nematocysts for adhesion to hosts, but the involvement of venom in this process is poorly understood. Recent work shows some myxozoans have a reduced repertoire of venom-like compounds (VLCs) relative to free-living cnidarians, however the function of these proteins is not known.

Methods
We searched for VLCs in the nematocyst proteome and a time-series infection transcriptome of Ceratonova shasta, a myxozoan parasite of salmonid fish. We used four parallel approaches to detect VLCs: BLAST and HMMER searches to preexisting cnidarian venom datasets, the machine learning tool ToxClassifier, and structural modeling of nematocyst proteomes. Sequences that scored positive by at least three methods were considered VLCs. We then mapped their time-series expressions in the fish host and analyzed their phylogenetic relatedness to sequences from other venomous animals.

Results
We identified eight VLCs, all of which have closely related sequences in other myxozoan datasets, suggesting a conserved venom profile across Myxozoa, and an overall reduction in venom diversity relative to free-living cnidarians. Expression of the VLCs over the 3-week fish infection varied considerably: three sequences were most expressed at one day post-exposure in the fish’s gills; whereas expression of the other five VLCs peaked at 21 days post-exposure in the intestines, coinciding with the formation of mature parasite spores with nematocysts. Expression of VLC genes early in infection, prior to the development of nematocysts, suggests venoms in C. shasta have been repurposed to facilitate parasite invasion and proliferation within the host. Molecular phylogenetics suggested some VLCs were inherited from a cnidarian ancestor, whereas others were more closely related to sequences from venomous non-Cnidarian organisms and thus may have gained qualities of venom components via convergent evolution. The presence of VLCs and their differential expression during parasite infection enrich the concept of what functions a “venom” can have and represent targets for designing therapeutics against myxozoan infections.
Determination of Heavy Metals in Soil around Amasoma Community in Bayelsa State, Nigeria
Authors: Assayomo Ebimobowei , Bawo Dorcas Dauta , Dieware Gbe-emi kemepade , Buseri Amaka Mariagoretti , Debekeme Ebikabowei John 
Published: December 2021

Aims: Anthropogenic activities such as crude oil exploration and exploitation has led to the suspicion of heavy metals contamination in the study area. This study investigated the concentration of zinc, nickel, lead and cadmium in the soil extracted from the area where Scent Leaf (Ocimum gratissimum) and Pawpaw tree (Carica papaya) are grown in Amassoma community, Bayelsa State, Nigeria.
Study Design: Scent leaf (Ocimum gratissimum) and Pawpaw tree (Carica papaya) soils from where these plants are grown were randomly collected for heavy metal analysis from within Amassoma community in Southern Ijaw Local Government Area of Bayelsa State, Nigeria
Place and Duration of Study: This study was carried out in Biological Sciences, Faculty of Science, Niger Delta University, Wilberforce Island, Amassoma, Bayelsa State between March 2019 to September 2019
Methodology: Scent leaf (Ocimum gratissimum) and Pawpaw tree (Carica papaya) soils were digested and analyzed for heavy metals using Atomic Absorption Spectrophotometer (AAS, model S471096). The method used was wet-ashing method for the analysis.
Results: the concentrations of Lead (Pb), Nickel (Ni), Cadmium (Cd), and Zinc (Zn), in pawpaw soil and scent leaf soil. From the sample data analysis, the average lead (Pb) contents in pawpaw soil and scent leaf soil were 1.283 mg/kg and 1.44 mg/kg respectively. The average Cadmium (Cd) in pawpaw soil and scent leaf soil were 0.256 mg/kg and 0.256 mg/kg respectively. The average Nickel (Ni) compositions in pawpaw soil and scent leaf soil were 4.71 mg/kg and 5.09 mg/kg respectively. While the Average Zinc (Zn) in pawpaw soil and scent leaf soil is 2.280 mg/kg and 2.160 mg/kg respectively. The soil analyzed for heavy metals were below the threshold target values recommended by the WHO.
Conclusion: The Scent leaf (Ocimum gratissimum) and Pawpaw tree (Carica papaya) soils analyzed for heavy metals were below the permissible limit recommended by WHO for soil safety. The result from the present study revealed that there may not be soil contamination as a result of the selected heavy metals, however, It is recommended that caution should be taken in regulating the anthropogenic activities that may tend to elevate the level of heavy metals in the surrounding to prevent contamination of soil over time which could be detrimental to the health of the populace.