bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptional fidelity enhances cancer cell line selection in pediatric cancers
Authors: Luck Cuyler , Yu Katharine , Okimoto Ross A. , Sirota Marina 
Published: October 2021

AbstractMulti-omic technologies have allowed for comprehensive profiling of patient-derived tumor samples and the cell lines that are intended to model them. Yet, our understanding of how cancer cell lines reflect native pediatric cancers in the age of molecular subclassification remains unclear and represents a clinical unmet need. Here we use Treehouse public data to provide an RNA-seq driven analysis of 799 cancer cell lines, focusing on how well they correlate to 1,655 pediatric tumor samples spanning 12 tumor types. For each tumor type we present a ranked list of the most representative cell lines based on correlation of their transcriptomic profiles to those of the tumor. We found that most (8/12) tumor types best correlated to a cell line of the closest matched disease type. We furthermore showed that inferred molecular subtype differences in medulloblastoma significantly impacted correlation between medulloblastoma tumor samples and cell lines. Our results are available as an interactive web application to help researchers select cancer cell lines that more faithfully recapitulate pediatric cancer.
Dose-dependent thresholds of dexamethasone destabilize CAR T-cell treatment efficacy
Authors: Brummer Alexander B. , Yang Xin , Ma Eric , Gutova Margarita , Brown Christine E. , Rockne Russell C. 
Published: October 2021

AbstractChimeric antigen receptor (CAR) T-cell therapy is potentially an effective targeted immunotherapy for glioblastoma, yet there is presently little known about the efficacy of CAR T-cell treatment when combined with the widely used anti-inflammatory and immunosuppressant glucocorticoid, dexamethasone. Here we present a mathematical model-based analysis of three patient-derived glioblastoma cell lines treatedin vitrowith CAR T-cells and dexamethasone. Advancedin vitroexperimental cell killing assay technologies allow for highly resolved temporal dynamics of tumor cells treated with CAR T-cells and dexamethasone, making this a valuable model system for studying the rich dynamics of nonlinear biological processes with translational applications. We model the system as a nonautonomous, two-species predator-prey interaction of tumor cells and CAR T-cells, with explicit time-dependence in the clearance rate of dexamethasone. Using time as a bifurcation parameter, we show that (1) dexamethasone destabilizes coexistence equilibria between CAR T-cells and tumor cells in a dose-dependent manner and (2) as dexamethasone is cleared from the system, a stable coexistence equilibrium returns in the form of a Hopf bifurcation. With the model fit to experimental data, we demonstrate that high concentrations of dexamethasone antagonizes CAR T-cell efficacy by exhausting, or reducing the activity of CAR T-cells, and by promoting tumor cell growth. Finally, we identify a critical threshold in the ratio of CAR T-cell death to CAR T-cell proliferation rates that predicts eventual treatment success or failure that may be used to guide the dose and timing of CAR T-cell therapy in the presence of dexamethasone in patients.Author summaryBioengineering and gene-editing technologies have paved the way for advance immunotherapies that can target patient-specific tumor cells. One of these therapies, chimeric antigen receptor (CAR) T-cell therapy has recently shown promise in treating glioblastoma, an aggressive brain cancer often with poor patient prognosis. Dexamethasone is a commonly prescribed anti-inflammatory medication due to the health complications of tumor associated swelling in the brain. However, the immunosuppressant effects of dexamethasone on the immunotherapeutic CAR T-cells are not well understood. To address this issue, we use mathematical modeling to studyin vitrodynamics of dexamethasone and CAR T-cells in three patient-derived glioblastoma cell lines. We find that in each cell line studied there is a threshold of tolerable dexamethasone concentration. Below this threshold, CAR T-cells are successful at eliminating the cancer cells, while above this threshold, dexamethasone critically inhibits CAR T-cell efficacy. Our modeling suggests that in the presence of high dexamethasone reduced CAR T-cell efficacy, or increased exhaustion, can occur and result in CAR T-cell treatment failure.
Homeodomain proteins hierarchically specify neuronal diversity and synaptic connectivity
Authors: Xu Chundi , Ramos Tyler B. , Rogers Edward M. , Reiser Michael B. , Doe Chris Q. 
Published: October 2021

AbstractHow our brain generates diverse neuron types that assemble into precise neural circuits remains unclear. UsingDrosophilalamina neuron types (L1-L5), we show that the primary homeodomain transcription factor (HDTF) Brain-specific homeobox (Bsh) is initiated in progenitors and maintained in L4/L5 neurons to adulthood. Bsh activates secondary HDTFs Ap (L4) and Pdm3 (L5) and specifies L4/L5 neuronal fates while repressing the HDTF Zfh1 to prevent ectopic L1/L3 fates (control: L1-L5; Bsh-knockdown: L1-L3), thereby generating lamina neuronal diversity for normal visual sensitivity. Subsequently, in L4 neurons, Bsh and Ap function in a feed-forward loop to activate the synapse recognition molecule DIP-β, thereby bridging neuronal fate decision to synaptic connectivity. Expression of a Bsh:Dam, specifically in L4, reveals Bsh binding to theDIP-βlocus and additional candidate L4 functional identity genes. We propose that HDTFs function hierarchically to coordinate neuronal molecular identity, circuit formation, and function. Hierarchical HDTFs may represent a conserved mechanism for linking neuronal diversity to circuit assembly and function.
Job insecurity and employees' safety voice behavior – a managerial dilemma caused by COVID-19
Authors: Salman Anum , Ahmed Ishfaq , Jahangir Sehrish 
Published: October 2021

PurposeThe world is witnessing enormous changes due to the outbreak of the COVID-19 epidemic. One of the unkind changes is the increased downsizing and layoffs, which has led to a situation of job insecurity. Moreover, due to the unavailability of a cure for the pandemic, the businesses have started their operations with added safety measures that demand a high level of employee safety behavior. But how job insecurity and safety voice may stay in one sheath is an area that requires attention. Hence, this study investigates the impact of job insecurity on employees' safety voice behavior in a COVID-19 outbreak, through serial mediation mechanisms of organizational support and trust.Design/methodology/approachData has been collected through a structured questionnaire from the sample (N = 213) of employees of service organizations.FindingsFindings of the study reveal that job insecurity is not directly linked with safety voice behavior, and therefore full mediation through perceived organizational support and trust is supported is proved.Originality/valueThis study covers the investigation of job insecurity, during pandemic COVID-19, and its effects on safety voice. It also explains the mechanism between the variables of interest through perceived organizational support and trust in the organization. The study is a timely contribution to the existing literature and offers both theoretical and managerial implications.
Disaster racism: using Black sociology, critical race theory and history to understand racial disparity to disaster in the United States
Authors: Breen Kyle 
Published: October 2021

PurposeThe purpose of this paper is to provide a call to action to use a new theoretical framework for disaster researchers that focuses on using a critical approach to understanding differential disaster impacts due to systemic racism.Design/methodology/approachUsing critical race theory (CRT) and Black Sociology, theoretical and disciplinary frameworks that center Black people and NBPOC as well as a focus in dismantling systemic racism and other oppressive systems, this article calls for a new approach – “disaster racism” – that builds on past discussions for a more nuanced theoretical approach to disaster studies.FindingsAlongside CRT and Black Sociology, this study identifies two examples of the oppressive systems that create disparate impacts to disaster including slavery and the legacy of slavery and mass incarceration.Originality/value“Disaster racism” – a critically focused approach – should be used in the future rather than social vulnerability to further dismantle oppressive systems and institutions, which not only provides strong theoretical backing to research but also creates an actively anti-racist research agenda in the discipline of sociology of disaster.
A dark side of e-HRM: mediating role of HR service delivery and HR socialization on HR effectiveness
Authors: Talukdar Asim , Ganguly Anirban 
Published: October 2021

PurposeThe primary aim of this paper is to study a dark side of e-HRM concerning its parallel effect on human resource (HR) socialization and HR service delivery and the consequent impact of perceived HR effectiveness.Design/methodology/approachThe current study started with an in-depth review of the extant literature in the field of e-HRM to derive a set of constructs. Based on the theoretical foundation of the identified constructs, the current study went on to derive a set of hypotheses, which was subsequently validated using the uses the quantitative technique of PLS-SEM. A primary survey, in the form of a structured questionnaire, was used as the source for data collection on a sample size of 276 from the Indian industrial domain. Careful attention was paid to eliminate the common method bias in the study.FindingsThe findings of this study show a simultaneous significant full mediation effect of both HR service delivery and HR socialization is the relationship between e-HRM and HR effectiveness. However, e-HRM has a strong and significant negative effect on HR socialization. Though HR socialization is positively related to HR effectiveness, the significantly reduced level of HR socialization as a consequence of adaption of e-HRM had negatively affected the perceived HR effectiveness.Originality/valueAlthough the dark side of e-HRM has been recognized by academicians and practitioners alike, its implications have seldom been studied in the academic literature. The current study intends to shed some light on this important, but sparsely discussed topic. Further, this study makes significant and meaningful contributions in the literature of e-HRM by empirically studying together the positive and negative consequences of e-HRM and its effects on HR effectiveness. Several e-HRM scholars have discussed the implications of e-HRM adoption and highlighted the negative impacts of e-HRM, and traversing the same path, the current study advances the literature by empirically investigating the effect of e-HRM on the dehumanization of HR processes and practices.
The uncontrollability of relational indifference in blended workgroups
Authors: Kristensen Anette Kaagaard , Kristensen Martin Lund 
Published: October 2021

PurposeThis paper aims to examine how temporaries’ experience and perception of encounters with permanent members’ relational indifference affect the social relations in blended workgroups.Design/methodology/approachConstructivist grounded theory study based on 15 semi-structured interviews with first- and third-year nursing students in clinical internships at somatic hospital wards was used.FindingsThe authors identified two themes around organizational alienation. Temporaries expected and hoped to experience resonance in their interactions with permanent members, which drove them to make an extra effort when confronted with permanents’ relational indifference. Temporaries felt insignificant, meaningless and unworthy, causing them to adopt a relationless mode of relating, feeling alienated and adapting their expectations and hopes.Practical implicationsRelational indifference is, unlike relational repulsion, problematic to target directly through intervention policies as organizations would inflict a more profound alienation on temporaries.Originality/valueUnlike previous research on blended workgroups, which has predominantly focused on relational repulsion, this paper contributes to understanding how relational indifference affects temporaries’ mode of relating to permanent.
Internal communication satisfaction and employee engagement as determinants of the employer brand
Authors: Špoljarić Anja , Tkalac Verčič Ana 
Published: October 2021

PurposeThis study aims to contribute to the understanding of internal communication and its connections to engagement and employer brands. The authors wanted to test the relationship between the three variables and explore if employees' perception of employer brands is affected by internal communication satisfaction and engagement. Creating a desirable employer brand can have significant benefits for organizations, such as higher employee satisfaction, employee engagement and retention. It is crucial to have a clear grasp of how the determinants of these relationships affect each other.Design/methodology/approachA total of 1,805 employees participated in a large communication survey that measured internal communication satisfaction, employee engagement and perception of employer brand (operationalized as employer attractiveness). To test the relationship between variables, the authors used multiple regression analysis.FindingsThe results show internal communication satisfaction and employee engagement as significant predictors of employer brand. All of the internal communication satisfaction dimensions and two out of three employee engagement dimensions have been identified as determinants of at least two employer attractiveness dimensions.Research limitations/implicationsLimitations include using a cross-sectional dataset, which reduces the possibility of determining causality, using self-reports and a common source bias.Originality/valueThe authors added to the body of knowledge by analyzing the effects of workplace attitudes on attitudes toward the organization. The authors found that both internal communication satisfaction and employee engagement significantly shape the perception of employer brands.
Family succession, professionalization and internationalization: a study of Brazilian family businesses
Authors: Costa Augusto Dalmoro , Zen Aurora Carneiro , Spindler Everson dos Santos 
Published: October 2021

PurposeThe purpose of this paper is to investigate the relationship between family succession, professionalization and internationalization in family businesses within the Brazilian context.Design/methodology/approachThe paper presents a multiple-case study method with three Brazilian family businesses that have at least two generations of the owning family involved in the business and an international presence of at least three years. In-depth interviews and secondary data were undertaken with family and non-family members of each case.FindingsThe authors' results show that a family business can boost its internationalization by introducing both succession planning and professionalization on international activities. As family members tend to be more risk-averse and focused on keeping the family business within the family, professionalization is a way of improving the firm's ability to expand internationally. This process tends to lead to lower performance by the firm for the first few months or the first year after the investment, but afterward, international performance tends to grow exponentially.Originality/valueOnly a few studies have been concerned on the relationship of these three dimensions. Thus, the research takes into account that professionalization and succession lead family businesses to improve their internationalization strategies.
Could banning virtual assets be a breach of the doctrine of legitimate expectation?
Authors: Haq Md. Zahurul , Farzana Kazi Fahmida , Md Moniruzzaman 
Published: October 2021

Purpose
This paper aims to examine the validity of a state’s prohibition on virtual assets in the context of its global commitment to battle against money laundering.

Design/methodology/approach
This was empirical legal research exploring how a general lack of expertise to apply a risk-based approach in anti-money laundering strategies might have implications for invoking the Financial Action Task Force (FATF) exclusion provisions in virtual asset regulation.

Findings
Invoking the exclusion provisions for banning virtual assets without meeting the prerequisites may put the financial system at risk and make a jurisdiction’s legal obligations appear breached.

Research limitations/implications
Anti-money laundering (AML) policymakers will take precautions and avoid misuse of the liberties they enjoy under FATF exclusion clauses/provisions.

Practical implications
The results of this study will help ensure more informed decision-making on the legal status and regulation of virtual assets.

Originality/value
The study helps ascertain the limits of privileges accorded to states under FATF exclusion provisions in applying global standards against money laundering.
Determinants ofde jureadoption of international financial reporting standards: a review
Authors: Bengtsson Maria Ming 
Published: October 2021

PurposeThe purpose of this paper is to systematically review extant studies on what makes a country fully, partially or not adopt international financial reporting standards (IFRS) and categorize these factors into meaningful categories. In so doing, this study facilitates policy-making for accounting and economic standard setters and also points out conflicting viewpoints in the current literature, thus, opportunities for future research.Design/methodology/approachThis paper is a literature review on academic studies that examine factors influencing national adoption of IFRS. The reviewed articles are limited to published, peer-reviewed papers only.FindingsOverall, the review suggests that although a wide range of determinants on national adoption of IFRS has been identified, prior literature consists of conflicting viewpoints on what influence national accounting policies toward IFRS, thus, highlighting areas in which there are needs for future research.Research limitations/implicationsFirst, this study focuses only on thede jureadoption of IFRS. Second, the study focuses mainly on research findings, not theory use in the extant literature.Originality/valueTo the best of the author’s knowledge, this is the first study, which provides a comprehensive review of studies onde jureIFRS adoption.
Meta-cognitive impairment in processing ingredients: the effects of jargon, list length and aids on young consumers’ evaluations of cosmetic products
Authors: Özdinç Yalım 
Published: October 2021

PurposeThis study aims to examine the nonidentical impacts of identical panel information that discloses cosmetic ingredients by their English (i.e. low jargon; e.g. vitamin E) versus scientific names (i.e. high jargon; tocopherol instead) presented in short versus crowded panel on young consumers’ confidence in processing ingredients information and product judgements. In the same context, this study also explores the effects of declarative aids provided within the ingredients panel.Design/methodology/approachThis study conducted four experiments by using a 2 (jargon: high, low) × 2 (ingredients list: short, long) between-subjects analysis of variance design.FindingsYoung consumers’ processing-confidence and product evaluations increase (decrease) when the panel is brief (crowded) and presents cosmetic ingredients in low (high) jargon (Experiments 1, 2). However, when it discloses a factual aid [i.e. ingredient functions; e.g. tocopherol (antioxidant)], confidence in processing even the high-jargon information, as well as product judgements, increases irrespective of the panel’s length (Experiment 3). Moreover, a fictitious aid (e.g. dryness-fighting “atomic robots”) stimulates the same effect and bolsters processing confidence and product evaluations irrespective of both jargon and panel’s length (Experiment 4).Originality/valueDespite their heavy use of over-the-counter beauty/cosmetic products, little do we know how young consumers consult and use on-pack ingredients information provided in one format versus the other. To the best of the author’s knowledge, this study is the first experimental work investigating the cosmetics-consuming youth’s reactions to panel format and aids to processing.
Clinical significance of the water retention and barrier function‐improving capabilities of ceramide‐containing formulations: A qualitative review
Authors: Kono Takeshi , Miyachi Yoshiki , Kawashima Makoto 
Published: October 2021

AbstractA decrease in the ceramide content of the stratum corneum is known to cause dry and barrier‐disrupted skin. In this literature review, the clinical usefulness of preparations containing natural or synthetic ceramides for water retention and barrier functions was evaluated. The PubMed, Cochrane Library, and Igaku Chuo Zasshi databases were searched using keywords such as “ceramide”, “skincare products”, “barrier + hydration + moisture + skin”, and “randomized trial”. All database searches were conducted in February 2019. Forty‐one reports were selected based on the following criterion: comparative control studies that evaluated the effects of ceramide‐containing formulations based on statistical evidence. Among the 41 reports, 12 were selected using the patient, intervention, comparison, and outcome approach. These 12 reports showed that external ceramide‐containing preparations can improve dry skin and barrier function in patients with atopic dermatitis. However, a double‐blinded comparative study with a large sample size is warranted for appropriate clinical use.
Pregnancy rates and outcomes in women with cystic fibrosis in the UK: comparisons with the general population before and after the introduction of disease‐modifying treatment, 2003–17
Authors: Esan OB , Schlüter DK , Phillips R , Cosgriff R , Paranjothy S , Williams D , Norman R , Carr SB , Duckers J , Taylor‐Robinson D 
Published: October 2021

ObjectiveTo compare pregnancy rates and outcomes for women with cystic fibrosis in the UK with those of the general population and assess the effect of the introduction of disease‐modifying treatment.DesignA population‐based longitudinal study, 2003–17.SettingUnited Kingdom.PopulationWomen aged 15–44 years in the UK cystic fibrosis (CF) Registry compared with women in England and Wales.MethodsWe calculated pregnancy and live‐birth rates for the CF population and the general population of England and Wales. For women with CF we compared pregnancy rates before and after ivacaftor was introduced in 2013. We further used CF registry data to assess pregnancy outcomes for mothers with CF, and to assess the relationship between maternal pre‐pregnancy lung function and nutritional status and child gestational age.Main outcome measuresPregnancy and live‐birth rates and child gestational age.ResultsOf 3831 women with CF, 661 reported 818 pregnancies. Compared with the general population, the pregnancy rate was 3.3 times lower in the CF population (23.5 versus 77.7 per 1000 woman‐years); the live‐birth rate was 3.5 times lower (17.4 versus 61.4 per 1000 woman‐years) with 70% of pregnancies in CF women resulting in live births; termination of pregnancy rates were also lower (9% versus 22%). Pregnancy rates increased post‐ivacaftor for eligible women with CF, from 29.7 to 45.7 per 1000 woman‐years. There was no association between pre‐pregnancy lung function/nutrition status and gestational age.ConclusionsPregnancy rates in women with CF are about one‐third of the rates in the general population with favourable outcomes, and increased for eligible women post‐ivacaftor.Tweetable abstractPregnancy rates in women with CF are about a third of the rate in England and Wales with 70% live births. Ivacaftor increases the rate.