bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple endocrine neoplasia syndrome
Authors: Krasnoselskyi М. V. , Svynarenko А. V. , Pidchenko N. S. , Simbirоva A. S. 
Published: July 2021

Background. Multiple endocrine neoplasia type 1 is a rare inherited disease that combines heterogeneous autosomal inherited disorders, the pathogenesis of which is based on hyperplasia or tumor transformation of several neuro- endocrine glands. In this pathology, treatment protocols are insufficient. Surgical treatment, suppressive or replacement therapy, radiation and chemotherapy are mainly used.
We presented a successful experience of combined radiotherapy of multiple pancreatic insulinoma as the main clinical manifestation of the syndrome of multiple endocrine neoplasia. The combination of intra-tissue brachytherapy and megavolt remote therapy in TFD, isoeffective 50 Gy, allowed to achieve reliable control of hypoglycemic attacks within 2 years of follow-up.
Purpose – to acquaint the medical community with successful experience of combined radiation treatment of multiple pancreatic insulinoma as a main clinical manifestation of the multiple endocrine neoplasia syndrome.
Materials and Methods. Clinical case of patient L., 30 years old, who received combined radiation therapy for clinically significant manifestations of hormonally active multiple insulinoma of the pancreas in the Department of Radiological Oncology of State Organization «Grigoriev Institute for Medical Radiology and Oncology of the National Academy of Medical Sciences of Ukraine».
Results. In May 2019, palliative contact brachytherapy was performed on the MULTISOURCE device. Total focal dose (TFD) for cells in the pancreas GENUS 3 Gy 5 times a week, TFD 18 Gy. At the end of brachytherapy, attacks of hypoclycemia were stopped. In March 2020, remote radiation therapy was performed on a linear accelerator CLINAC-600C (6MeV) in the mode of classical fractionation (single focal dose (SFD) 1.8 Gy 5 times a week), TFD for the entire volume of the pancreas 30.6 Gy. In May 2021, CT scan showed that the process in the pancreas was stabilized, but in connection with the resumption of hypoglycemia and the emergence of dyshormonal osteopathy, a course of remote radiation therapy for the entire pancreas, SFD 1.8 Gy, TFD 20 Gy simultaneously with the introduction of bisphosphonates.
Conclusions. Our patient demonstrates type I syndrome of multiple neo- plasms, neuroendocrine tumor of pancreas G1 T3N0M0 IIB stage. Due to multi-stage combined radiation therapy for 2 years it is possible to achieve stabilization of the process and reliable control of hypoglycemic attacks, which indicates the effectiveness of this method as an alternative to surgery in unresectable cases.
Epidemiological Pattern of Esophageal Cancer based on the Database Analysis of National Cancer Registry of Ukraine
Authors: Shcherbynina M. B. , Soloviova N. E. 
Published: July 2021

Background. Esophageal cancer remains a major medical challenge since it belongs to the most aggressive malignant neoplasms, usually diagnosed at a late stage of the disease.
Purpose – Studying the general patterns of time course of esophageal cancer epidemiological status in terms of morbidity and mortality among the adult population of Ukraine within the period from 2014 to 2019.
Materials and Methods. General and standardized morbidity and mortality rates resulting from esophageal cancer from 2014 to 2019 throughout Ukraine and in terms of administrative territories per 100 thousand adult population have been researched along with calculating the growth rate. The study was carried out based on the data of National Cancer Registry of Ukraine.
Statistical processing of the obtained data was performed by means of generally accepted statistical methods.
Results and discussion. The all-Ukrainian incidence of esophageal cancer averaged 4.5 per 100 thousand population. Zhytomyr, Sumy and Chernihiv regions can be considered as the regions with the highest incidence of esophageal cancer. The lowest number of esophageal cancer cases was found in Chernivtsi and Odesa regions of Ukraine.
Esophageal cancer mortality rates ranged slightly from 3.3 to 3.6 per 100 thousand population, but it reduced by 8.3% within six years. Monitoring changes of esophageal cancer mortality rate over time, in 2014 and 2019 in Ivano-Frankivsk, Mykolaiv and Rivne regions and in Kyiv it increased by more than 20%. A 30% reduction in mortality was observed in Kirovohrad, Odesa, Kharkiv and Zhytomyr regions. In 2019, Odessa and Kirovograd could be considered the regions with a low mortality rate showing 2.1 per 100 thousand population. In 2018, 88% of esophageal cancer cases were diagnosed in men and only 12% in women. The vast majority of cancer patients were aged 50 to 80 years. Mortality from esophageal cancer was significantly higher in men (91.2%) compared to women.
Conclusions. The consistency of morbidity and mortality levels of esophageal cancer among the population of Ukraine during 2014-2019 has been established with insignificant regional disparities.
Functional activity of animal bone marrow cells after their treatment with nanocomplexes
Authors: Goltsev A. M. , Dubrava T. G. , Gaevska Yu. O. , Babenko N. M. , Bondarovych M. O. , Lutsenko O. D. 
Published: July 2021

Background. Previously, the antitumor activity of nanocomplexes (NCs) containing nanoparticles of rare earth metal orthovanadates GdYEuVO4 and cholesterol has been approved when applied in 9:1 ratio (the cells-to-NCs), which can be considered as a conditionally therapeutic dose. Therefore, studying the potential risks of NCs exposure in terms of functional activity of hematopoietic progenitor cells is relevant.
Рurpose – determining a toxic effect of NCs on functional activity of hematopoietic cells of bone marrow (BM).
Materials and Methods. The study was performed in BM cells of CBA/H mice. Nanocomplexes were synthesized at Institute for Scintillation Materials of the National Academy of Sciences of Ukraine. BM cells with NCs were incubated in the ratios as follows: 9BM:1NCs; 1BM:1NCs; 1BM:9NCs, followed by assessing the number of apoptotic/necrotic cells in BM using FITC Annexin V Apoptosis Detection Kit I (BD, USA) by means of “FACS Calibur” flow cytometer (“BD”, USA). Hematopoietic progenitor cells of BM were functionally evaluated in vivo by determining the content of colony-forming units of the spleen (CFUs) and the number of myelokaryocytes in lethally irradiated recipients on day 8 after administering BM cells, pre-incubated with NCs. Survival of irradiated recipient mice after BM administration was recorded 12 days long.
Results and discussion. The dose-dependent effect of functional potential in- hibition for BM hematopoietic progenitor cells under NCs influence has been established. Although, in vitro processing the BM cells with a conditionally therapeutic dose of NCs (9BM:1NCs) before administration to irradiated animal caused remodeling of cell membranes and contributed to apoptotic manifes- tations, but it did not lead to strong changes in their colony-forming potential and did not reduce the number of BM cells in animals if compared with the introduced BM cells without NCs treatment. Increasing the NCs concentration five- and tenfold significantly reduced the colony-forming potential of BM cells, caused BM hypoplasia and a crucial reduction in the survival of recipient animals, indicating possible toxic effects of this compound when administered at high concentrations.
Conclusions. The toxic effect of NCs is detected only when certain concen- trations, significantly exceeding the conditionally therapeutic dose previously determined when treating the experimental oncology diseases, are used.
PODCAST “SABERES TRADICIONAIS: QUE HISTÓRIAS QUEREMOS CONTAR?” PARA A FORMAÇÃO DE PROFESSORES DE CIÊNCIAS E BIOLOGIA
Authors: DE MOURA MATTOS ALINE , BRITO NOGUEIRA VIVIANE 
Published: July 2021

O PODCAST “SABERES TRADICIONAIS: QUE HISTÓRIAS QUEREMOS CONTAR?” SURGE DE INQUIETAÇÕES ACERCA DOS CONHECIMENTOS VALORIZADOS EM NOSSA FORMAÇÃO ESCOLAR E UNIVERSITÁRIA. FOI ELABORADO COMO UM MATERIAL DIDÁTICO A FIM DE COMPLEMENTAR REFLEXÕES INICIAIS DE LICENCIANDOS(AS) DO CURSO DE CIÊNCIAS BIOLÓGICAS. ESSE MATERIAL CONTRIBUIU PARA A FORMAÇÃO INICIAL DE PROFESSORES DE CIÊNCIAS E BIOLOGIA NA MEDIDA EM QUE PROPORCIONOU POSSIBILIDADES PARA DISCUSSÕES E REFLEXÕES ACERCA DA DIVERSIDADE DE SABERES, (RE)CONHECENDO AS LUTAS E RESISTÊNCIAS DE GRUPOS CULTURAIS, BEM COMO CONTRIBUIU PARA O ENGAJAMENTO DOS(AS) LICENCIANDOS(AS) NA CONSTRUÇÃO DE PROPOSTAS DE ENSINO QUE VALORIZASSEM AS DIVERSAS FORMAS DE PERCEBER AS CIÊNCIAS, AS VIDAS, OS MUNDOS. ESSE PODCAST SE CONSTITUI COMO MAIS UMA INICIATIVA QUE BUSCA INTEGRAR CONHECIMENTOS E SABERES NÃO HEGEMÔNICOS À FORMAÇÃO DE PROFESSORES. ALMEJAMOS UM ENSINO DE CIÊNCIAS E BIOLOGIA QUE NÃO CAIA NA ARMADILHA DA COLONIALIDADE, QUE INSISTE EM CONTAR UMA HISTÓRIA SÓ.
Educación virtual, el disfraz de la enseñanza remota de emergencia
Authors: Alonzo Mayén Diana María 
Published: July 2021

La pandemia de la COVID-19 generó que de forma abrupta la comunidad educativa del mundo entero implementara medidas para no detener el año escolar. La efectividad del proceso de aprendizaje y la necesidad de una rápida adaptación pueden disminuir la calidad de los recursos y la educación. La Universidad de San Carlos de Guatemala no fue la excepción, he implementó acciones rápidamente. El objetivo principal de este estudio fue analizar las acciones implementadas, esto permitirá desarrollar una estrategia coherente y bien definida de un plan de emergencia para activar en cualquier momento la Enseñanza Remota. Para ello, se aplicó un método de investigación mixto; este se realizó en el Centro Universitario de Suroccidente, tomando como muestra, a los estudiantes y profesores del cuarto semestre de la Licenciatura de Ciencias de la Comunicación, durante el mes de marzo hasta noviembre de 2020. Los resultados fueron contrastados con el testimonio brindado por representantes de la División de Educación a Distancia en Entornos Virtuales y el coordinador de la carrera mencionada. La investigación dejó al descubierto muchas debilidades y carencias que tienen no solo los centros regionales sino el equipo docente y los mismos estudiantes. Por ejemplo, la mayoría de estudiantes únicamente tienen teléfono celular para acceder a sus clases, limitándose así a realizar las actividades colaborativas. Se evidenció que los alumnos están familiarizados a las redes sociales, más no con herramientas educativas aplicadas a la educación.
(Des) legitimação da informação contábil em processos licitatórios no Brasil
Authors: Ribeiro Rafael Borges , Miranda Gilberto José , Azevedo Ricardo Rocha de 
Published: July 2021

O objetivo deste estudo consiste em analisar a legitimidade da informação contábil na etapa de qualificação econômico-financeira (QEF) das licitações públicas que envolvem obras de construção civil e serviços de mão de obra terceirizada. Para a interpretação do fenômeno se utilizou dos atributos da legitimidade normativa (normativity) e das características qualitativas da informação contábil presentes na Estrutura Conceitual da contabilidade. Os resultados baseiam-se em análise documental de processos licitatórios de seis instituições federais de ensino superior, complementado por entrevistas com agentes que atuam no processo de QEF. Os resultados indicam que a informação contábil tem sido vista com baixa legitimidade, o que têm prejudicado a avaliação econômica das empresas no processo licitatório. No aspecto teórico, a pesquisa contribui sugerindo que a baixa legitimidade da informação contábil perfaz em fator relevante para seu uso cerimonial, o que pode ser útil para pesquisas e para a prática.
Pemberdayaan Bidan Dalam Stimulasi Taktil Kinestatik Untuk Meningkatkan Pertumbuhan Dan Perkembangan Bayi Riwayat Berat Lahir Rendah
Authors: Yusniarita Yusniarita , Indah Purnama Eka Sari Wenny , Puspita Yenni 
Published: July 2021

Masalah Bayi Berat Badan Lahir Rendah (BBLR) penting diperhatikan karena sangat erat berkaitan dengan kelangsungan hidup bayi tersebut selanjutnya. Standar Profesi Bidan menyebutkan bahwa bidan mempunyai kewenangan untuk melaksanakan pemantauan dan menstimulasi tumbuh kembang bayi dan anak. Salah satu bentuk stimulasi tumbuh kembang yang selama ini dilakukan oleh bidan adalah stimulasi taktil kinestetik. Kegiatan pengabdian masyarakat bertujuan untuk pemberdayaan bidan untuk meningkatkan pengetahuan dan keterampilan melalui workshop dan pelatihan bidan dalam melakukan stimulasi taktil kinestatik untuk meningkatkan pertumbuhan dan perkembangan bayi riwayat BBLR. Sasaran Kegiatan adalah bidan yang berjumlah 15 orang di Wilayah Kerja Puskesmas Ujan Mas Kabupaten Kepahiang tahun 2020. Sesuai arahan Presiden untuk selalu dapat menaati arahan dan protokol kesehatan yang telah disampaikan oleh pemerintah. Kegiatan pengabdian kepada masyarakat telah dilaksanakan secara online. Kegiatan dilaksanakan dengan menggunakan ClouldX dan WAG. Hasil pre test dan post test peserta menunjukan peningkatan pengetahuan sebesar 34,66, dan hasil penilaian keterampilan dengan menggunakan daftar tilik diperoleh rerata nilai 80,83. Kegiatan pengabdian kepada masyarakat dengan memberdayakan bidan melalui melatih keterampilan bidan dapat meningkatkan pengetahuan dan keterampilan bidan dalam melakukan stimulasi taktil kinestetik.
L.C. VS. PERÚ: LA BATALLA DE UNA NIÑA POR ACCEDER A LA JUSTICIA REPRODUCTIVA
Authors: ÁLVAREZ ÁLVAREZ BRENDA IBETTE 
Published: July 2021

En el presente artículo se aborda las restricciones y obstáculos en el goce del derecho a la interrupción legal del embarazo en casos de niñas víctimas de violencia sexual a partir de los estándares jurídicos del derecho internacional de los derechos humanos planteados en el caso L.C. vs. Perú del Comité para la Eliminación de la Discriminación Contra la Mujer (Cedaw). Asimismo, se plantea un análisis de los argumentos presentados por las representantes de la peticionaria, los descargos del Estado peruano y del razonamiento esgrimido por el Comité CEDAW en el caso.
ABSTRACT
This article addresses the restrictions and obstacles in the enjoyment of the right to legal interruption of pregnancy in cases of girls victims of sexual violence based on the legal standards of international human rights law raised in the L.C. vs. Peru of the Committee for the Elimination of Discrimination Against Women (Cedaw). Likewise, an analysis of the arguments presented by the petitioner's representatives, the Peruvian State's defense and the reasoning put forth by the CEDAW Committee in the case is presented.
INFLUENCE OF CAPACITY BUILDING TRAINING BY AGRICULTURAL MEDIA RESOURCES AND EXTENSION CENTRE (AMREC) ON RURAL FARMERS’ LIVELIHOODS IN ODEDA LOCAL GOVERNMENT AREA OF OGUN STATE
Authors: ADEYEYE O. A. , IREKHORE O. T. 
Published: July 2021

The role of extension service providers as practical problem-solving organizations in rural settings is targeted at poverty reduction, various mechanisms including capacity building training is adopted in achieving this. Purposive selection of hundred and twelve (112) beneficiaries from 14 communities was made. The mean age of respondents is 39years. The household size is 6persons and the farm size is 2.3hectares. Farming experience is 8years and the average yield is 184.6kg, average annual income after the training is N15, 732.00k. 62.5% and 37.5% of farmers respectively benefitted from crop and livestock training and also have access to hybrid stems and seeds. Results indicates positive relationship between farm size (r = 0.397, p = 0.001), farm yield (r = 0.555, p = 0.004) and farmers income (r = 0.808, p = 0.002), farmers’ sex, (χ2 =10.63, df = 1, P > 0.05) and the purpose of attending the training (χ2 =11.67, df = 4, P > 0.05). The mean score of farmers’ response on perception about the benefits of capacity building training on their livelihoods is 3.66. 95.5% and 80.4% strongly agreed that the training has assisted in poverty reduction and that it is a developmental issue targeted at building human resources.
GROWTH AND YIELD RESPONSES OF OPEN POLLINATED MAIZE (Zea mays) TO TYPES AND RATES OF ORGANIC FERTILISERS IN RAINFOREST TRANSITORY AGROECOLOGY OF NIGERIA
Authors: ADERIBIGBE S. G. , SAKARIYAWO O. S. , SORETIRE A. A. , OYEKANMI A. A. , SOREMI P. A.S. 
Published: July 2021

Sustainable maize (Zea mays) production in resource challenged regions of the world is achievable among others through optimal utilisation of organic fertilisers at varying rates. Field trials were conducted in Abeokuta (Latitude 7010' N and Longitude 3015' E) in the late cropping season of 2010 and 2011. Three commercially available organic fertilisers [(Gateway 1 (GF1), Gateway 2 (GF2) and Sunshine (SF)], at three rates (0, 10 and 20 t ha-1) and three replicates were used on improved open-pollinated maize variety (Swam 1 yellow). The experiment was laid out in a randomised completely blocked design. GF1 had significantly (P < 0.05) the highest effect on growth parameters (Plant height, stem girth, leaf area and leaf area Index), with SF the least. A significant depression was observed in most growth parameters at increasing application rates of organic fertiliser, a converse pattern was observed on 1000 grain weight (GW), harvest index and cob length. A significantly higher (P < 0.05) vegetative growth, cob weight and grain yield was observed in 2010 than 2011, while 2011 had longer cobs and more 1000 GW than 2010. GF1 was recommended in Rainforest transitory zone of Nigeria at higher application rates though mediated by environmental factors.
Keywords: , , ,
SIAM WEED (Chromolaena odorata) AND COWDUNG COMPOST EFFECTS ON PHYSICOCHEMICAL PROPERTIES, YIELD and MINERAL NUTRITION OF TOMATOES(Lycopersicon esculentum L)
Authors: AKINTOKUN P. O. , AKINTOKUNN A. K. , OSHO M. R. , OYEBADE B. A. 
Published: July 2021

Greenhouse trials were conducted to evaluate the effects of siam weed (chromolaena odorata) and cowdung compost on physicochemical properties, yield and mineral nutrition of tomatoes(lycopersicon esculentum l). The nutritional value of tomato makes it one of the crop that is a daily household consumption by every family.Compost was prepared in this study from Siam weed (Chromolaena odorata) and cowdung. Three compost samples were prepared from Cowdung and siam weed at ratio 100g: 100g (sample A), 200g chopped siam weed (sample B) and 200g cowdung (sample C). These three samples were composted in plastic drums perforated for aeration and each sample was replicated three times. The content in the drums were regularly turned and monitored at 1, 10, 30 and 60 days for physicochemical properties. The physicochemical and mineral element analyses of the compost were carried out using standard procedures.The pH of the composted samples ranged between 5.8 to 6.9. Nitrogen, phosphorus and potassium contents increased with days of composting while those of heavy metals decreased. The result of plant height for the two varieties ranges between 5.31-119.8, number of fruits is between 11-21 and the yield (kg) parameter ranges between 0.76-1.91. Treatment. A gave higher mineral element over other treatment applied. The order of mineral elements contributed to the fruits were as follows treatments A>C>B>D
INFLUENCE OF HUMAN RESOURCE MANAGEMENT PRACTICES ON AGRICULTURAL EMPLOYEE’S BEHAVIOUR IN OYO STATE, NIGERIA
Authors: ABIONA B. G. , FAPOJUWO O E , AKINLAWON T. 
Published: July 2021

his study assessed the influence of human resource management practices on agricultural employees’ behavior. Data were collected from 75 randomly selected agricultural employees using a well-structured questionnaire. Data gathered were analysed using descriptive and inferential statistical tools. The mean age of the employees’ was 43.2 years. In-service training (=3.44), management reward employees who are committed to their job (=3.41) and wide participation and activity is highly rewarded (=3.41) were the major human resource management practices that influenced employees behaviors. Also, major employees’ behavior include creation of conducive environment for better job performance (=3.13) and praise, recognition and appreciation of effective performance/special effort (=3.05). Factors affecting employees’ behavior were inadequate training (=2.93) and inadequate grants/funds to attend training programmes (=2.81). Significant relationships existed between gender (χ2 = 37.20, p<0.005), educational qualification (χ2 = 59.09, p<0.005), income (r=0.12, p<0.005), human resource management practices (r = 0.57, p<0.005) and employees’ behavior. Management should encourage employees who are committed to their job through awards and recognition of work done.
STORABILITY AND PRE-SOWING TREATMENTS OF AFRICAN STAR APPLE (CHRYSOPHYLLUM ALBIDUM G. Don) SEEDS
Authors: ADELANI D. O. , ADURADOLA M. A. , AIYELAGBE I. O.O 
Published: July 2021

Chrysophyllum albidum is a prominent, indigenous, economic fruit tree species found in compound farm agro-forestry systems . Investigation was conducted to overcome difficulty in germination and storability of C. albidum seeds in the forest nursery of Federal University of Agriculture, Abeokuta, Nigeria. The trial employed a 3x3 factorial experiment with three replications laid out in a completely randomized design to determine the effect of seed coat treatments including clipping at 2mm from distal, circumference and micropyle end; dipping in 10% sulphuric acid and no seed coat treatments and durations of seed storage 1, 5 and 9 days on the germination of C. albidum seeds. Pre-sowing and storage treatments significantly (p < 0.05) affected the germination of seeds. Percentage germination ranged from 17% to 61% for clipping to no seed coat treatment. Highest germination of 61% was recorded for seeds not pre-sowed. The percentage germination ranged from 16% to 60% for seeds stored for nine days to those stored for one day. Highest germination of 60% was recorded for seeds stored for one day. A significant (p < 0.05) decrease in percentage germination was recorded with increasing days of storage. The result of interaction effect revealed that highest germination of 86% was recorded for seeds stored for 5days without pre-sowing treatments. Storing of seeds for 5days is recommended for mass production of C. albidum seedlings in agro-forestry nursery.