bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between sensory reactivity differences and mental health symptoms in preschool‐age autistic children
Authors: Rossow Timothy , MacLennan Keren , Tavassoli Teresa 
Published: May 2021

AbstractThere is growing evidence for an association between sensory reactivity and mental health in autism. This study set out to explore the relationship between sensory reactivity and mental health in preschool‐aged autistic children. In total 54 preschool‐aged children with an Autism Spectrum Condition took part. Sensory and mental health symptoms were obtained from the Sensory Processing Scale Inventory, Sensory Assessment of Neurodevelopmental Differences and the Behavioral Assessment System for Children–3. Correlational analyses showed a relationship between sensory reactivity and mental health symptoms in autistic preschool‐aged children. Results also indicate divergence in sensory‐mental health profiles between autistic preschool‐aged children who are verbal and those who use few to no words. For the first time this study has revealed a relationship between sensory hyper‐reactivity, as well as sensory seeking, and mental health symptoms outside of anxiety in autism. Of note, this relationship between sensory hyper‐reactivity and internalizing symptoms appears to be driven by those with few to no words. This has implications for both research and clinical interventions, in particular for our understanding of the factors underlying mental health symptoms in different autistic phenotypes, as well as the possible role of functional communication in mitigating the development of mental health symptoms.Lay SummaryThe present study found that in autistic preschoolers, externalizing mental health symptoms, such as hyperactivity, are related to sensory seeking (seeking out or being fascinated with sensory stimuli), and internalizing mental health symptoms, such as depression, are related to sensory hyper‐reactivity (sensitivity to sensory stimuli). Our results also show that whilst the relationships between externalizing symptoms and sensory seeking is seen across participants, the relationship between internalizing symptoms and sensory hyper‐reactivity was only seen in autistic preschoolers who used few to no words. This has important implications for the assessment of sensory differences as part of more rigorous mental health assessments, especially in autistic people who use few to no words.
Systematic expression analysis of m6A RNA methyltransferases in clear cell renal cell carcinoma
Authors: Gundert Larissa , Strick Alexander , von Hagen Felix , Schmidt Doris , Klümper Niklas , Tolkach Yuri , Toma Marieta , Kristiansen Glen , Ritter Manuel , Ellinger Jörg 
Published: May 2021

AbstractObjectivesTo investigate the regulation of the N‐6‐methyladenosine (m6A) methyltransferases METTL3, METTL14, WTAP, KIAA1429, and METTL4, referred to as “m6A writers,” in clear cell renal cell carcinoma (ccRCC), and other RCC subtypes in respect of the potential prognostic value.Patients and methodsTissue samples were collected within the framework of the Biobank at the Center for Integrated Oncology Bonn. The expression of the methyltransferases was systematically determined in clear cell renal carcinoma (ccRCC) on the RNA (real‐time PCR) and protein level (immunohistochemistry). Additionally, protein expression of the m6A writers was further investigated in papillary RCC, chromophobe RCC, sarcomatoid RCC, oncocytoma, and normal renal tissue (immunohistochemistry).ResultsThe expression of all m6A‐methyltransferases was significantly downregulated in ccRCC compared to benign renal tissue. Low m6A‐methyltransferase levels were correlated with higher histological grade, advanced pT‐stage, pN‐stage, and metastatic disease. Reduced m6A‐methyltransferase expression was associated with shorter overall survival.ConclusionIn conclusion, m6A‐methyltransferases are dysregulated in ccRCC and might act as tumor suppressor genes, which could be of particular importance for future diagnostic and therapeutic options.
Categories, components, and techniques in a modular construction of basket trials for application and further research
Authors: Pohl Moritz , Krisam Johannes , Kieser Meinhard 
Published: May 2021

AbstractBasket trials have become a virulent topic in medical and statistical research during the last decade. The core idea of them is to treat patients, who express the same genetic predisposition—either personally or their disease—with the same treatment irrespective of the location of the disease. The location of the disease defines each basket and the pathway of the treatment uses the common genetic predisposition among the baskets. This opens the opportunity to share information among baskets, which can consequently increase the information of the basket‐wise response with respect to the investigated treatment. This further allows dynamic decisions regarding futility and efficacy of individual baskets during the ongoing trial. Several statistical designs have been proposed on how a basket trial can be conducted and this has left an unclear situation with many options. The different designs propose different mathematical and statistical techniques, different decision rules, and also different trial purposes. This paper presents a broad overview of existing designs, categorizes them, and elaborates their similarities and differences. A uniform and consistent notation facilitates the first contact, introduction, and understanding of the statistical methodologies and techniques used in basket trials. Finally, this paper presents a modular approach for the construction of basket trials in applied medical science and forms a base for further research of basket trial designs and their techniques.
The Social Referencing Observation Scale (SoROS) for children: Scale development and reliability
Authors: Lubomirska Anna , Eldevik Sigmund , Eikeseth Svein , Strømgren Børge , Budzińska Anna 
Published: May 2021

AbstractThe Social Referencing Observational Scale (SoROS) is being developed to measure and detect deficits in social referencing skills in children between 2.6 and 5.0 years of age. This study is the first in the sequence, describing the first phases of development. First, three different scenarios designed to evoke social referencing behaviors were selected. We called the scenarios Fear, Pain, and Joy. In the pilot study, social referencing in 60 typical children was scored. Based on the data from the pilot study, the scoring system was refined and another 204 children were tested. We report descriptive data on social referencing in typical children across age and gender. Our main finding was that all children showed social referencing in that they first looked for cues in another person as for how to behave, and second behaved accordingly. This was the case across all three tested scenarios. Inter‐rater reliability for individual scoring behaviors in all three scenarios was good to high. The descriptive data for how typical children behave in these scenarios can provide the basis for detecting deficits in social referencing and for planning interventions.
Impairment of eye emotion discrimination in benign childhood epilepsy with centrotemporal spikes: A neuropsychological study
Authors: Wu Lulu , Yang Xinyu , Zhang Kaili , Wang Xiaocui , Yang Bin 
Published: May 2021

AbstractPurposeTo explore the characteristics of the impairment of eye emotional recognition and related clinical factors in children with benign childhood epilepsy with centrotemporal spikes (BECT).MethodsThe Eye Basic Emotion Discrimination Task and Eye Complex Emotion Discrimination Task were used to study emotion discrimination in 33 recently diagnosed BECT patients and 33 BECT patients after complete remission compared to respective age‐ and gender‐matched comparison participants.ResultsThe scores for discrimination of sadness, fear, and disgust were significantly lower in the newly diagnosed BECT group than in the comparison group (p = .004, p = .019, and p = .044, respectively), while scores for recognizing happiness, anger, and surprise were not significantly different between the two groups (p = .248, p = .586, and p = .540, respectively). Our analysis revealed that the BECT onset age influences the scores for recognition of sadness, fear, and disgust (OR = 1.795, 95% CI: 1.097 to 2.936, p = .020; OR=1.846, 95% CI: 1.124 to 3.034, p = .016; OR = 1.851, 95% CI: 1.131–3.029, p = .014). After remission, the scores for discrimination of happiness, anger, sadness, fear, disgust, and surprise of the BECT group were not significantly different from the comparison group (p = .588, p = .765, p = .752, p = .984, p = .328, and p = .339, respectively).ConclusionsIn our study, newly diagnosed BECT patients exhibited emotion discrimination dysfunction, mainly related to sadness, fear, and disgust, and this dysfunction was more severe the younger the age of onset was. However, after BECT remission, the ability to discriminate emotions returned to normal.
The growth paradox, sustainable development, and business strategy
Authors: Edwards Mark G. 
Published: May 2021

AbstractEconomic growth is a two‐edged sword. Expanding economies and industries create wealth and employment, but global economic expansion is having unprecedented deleterious impacts on vital planetary systems. Despite this, the core strategic goal of all economies and many businesses continues to be the pursuit of ongoing economic growth. To resolve this paradox, a reconceptualization of firm‐level growth is presented. I describe and discuss the organizational characteristics of the growth paradox and follow this with a metatheoretical review of economic, organizational, and ecological perspectives on growth. From this review, a typology of firm‐level strategy is developed that radically reconceptualizes business growth as developmental activity primarily concerned with social–ecological flourishing. The features of this typology and its implications for business strategy are discussed according to three principles that emerged from the analysis: multidexterity, resilience thinking for design, and inclusive balance (embeddedness). Together, these strategy principles form the prerequisite management competencies needed for the development, implementation, and evaluation of sustainable business strategies. Transformative firm‐level responses to the growth paradox are needed if sustaining forms of organizational growth are to be achieved and this paper presents a novel integrative framework for informing those strategies.
Circular economy, the transition of an incumbent focal firm: How to successfully reconcile environmental and economic sustainability?
Authors: Gandolfo Alessandro , Lupi Lorenzo 
Published: May 2021

AbstractCircular economy (CE) has garnered increasing attention in political circles and practitioner literature thanks to its potential to overcome the harmful consequences of linear patterns of growth. Nonetheless, the adoption of sustainable practices entails a holistic approach requiring businesses to make significant changes to their production, technologies and stakeholder management. These challenges resulted in limited progress in terms of the practical implementation of CE. This paper addresses the need for more literature focused on the pragmatic aspects of applying this paradigm to incumbent firms. The author presents the journey that Lucart S.p.A., a major European tissue paper manufacturer, has undertaken between 2014 and 2020 to apply CE principles to its practices. Insights from the transformation process, reconstructed through interviews with the firm's management and environmental impact data, suggest that to succeed it takes innovating (plants, products and marketing strategies) and setting up supply chains that reconcile environmental and economic sustainability.
Health care access and utilization among adult cancer survivors: Results from the National Institutes of Health “All of Us” Research Program
Authors: Coughlin Steven S. , Chen Jie , Cortes Jorge E. 
Published: May 2021

AbstractBackgroundMany cancer survivors face financial difficulties that prevent them from receiving appropriate health care. Racial/ethnic disparities in receipt of health care have been reported among cancer survivors, but recent data for important racial/ethnic subgroups of the US population are lacking.MethodsTo learn more about barriers to healthcare access faced by cancer survivors, we analyzed data from the NIH “All of Us” Research Program. Data were analyzed about demographic factors and other personal characteristics, personal medical history of cancer, healthcare utilization, and access to care.ResultsAs of November 2020, a total of 5426 participants had a history of cancer (excluding skin cancer). About 88.2% were non‐Hispanic White; 3.9% were Black, African American, or African; 1.3% were Asian; 4.1% were Hispanic, Latino, or Spanish; and 1.2% reported more than one race. Just over one‐half had an annual income of $75,000 or greater. The majority of the participants (71.7%) were college graduates or had an advanced degree. About 47.0%% had private health insurance, 41.0% had Medicare, 6.0% had Medicaid, and the remainder had military, Veterans Affairs, other insurance, or no health insurance. Frequently cited reasons for delayed care in the past 12 months were “had to pay out of pocket for some or all of the procedures,” “deductible was too high/or could not afford the deductible,” “couldn't afford the copay,” “couldn't get time off work,” and “were nervous about seeing a health care provider.”DiscussionA minority of cancer survivors who participated in the NIH “All of Us” Program had difficulty paying for health care in the past 12 months. Of particular concern are minorities such as African American and Hispanic cancer survivors along with those who are low income.
Toward an agency and reactance theory of crowding: Insights from COVID‐19 and the tourism industry
Authors: Lim Weng Marc 
Published: May 2021

AbstractIn the midst of the coronavirus pandemic, this article endeavors to offer expeditious insights into the impact of the global humanitarian crisis on the tourism industry from a consumer behavior perspective. To do so, this article employs the theory of crowding as an overarching theoretical lens, the coronavirus disease 2019 (COVID‐19) as a context to represent a global humanitarian crisis, and the rapid review approach as a method to source maiden evidence. In doing so, this article sheds light on instances of undercrowding (undertourism) and overcrowding (overtourism) in tourism as a result of COVID‐19, with interpretations enriched by agency theory and reactance theory—thereby resulting in the emergence of a new theory called the agency and reactance theory of crowding. The article concludes with pragmatic implications in light of the global humanitarian crisis.
Use of tea fibers as a source of dietary fiber in wheat flour and bread
Authors: Arı Akın Pervin , Tayfun Kübra Elif , Tamer Uğur , Boyacı İsmail Hakkı 
Published: May 2021

AbstractBackground and objectivesTea fiber is a co‐product of black tea production. It is a cheap and good source of fiber and polyphenols. In this study, the impact of finely ground tea fiber addition (2.5, 5.0, 7.5, and 10.0%) on wheat dough and bread was evaluated.FindingsTea fiber contained 8.39% moisture, 15.65% protein, 1.58% fat, 3.63% ash, 17,289 mg GAE/kg tea fiber phenolic, and 67.62% total dietary fiber. The addition of tea fiber (2.5%, 5.0%, 7.5%, and 10.0%) decreased dough stability and extensibility, index of swelling, baking strength, loaf volume, and specific volume while increased dough development time, water absorption, dough tenacity, configuration ratio, the degree of dough softening and firmness. The baking loss of bread made with tea fibers and control were not significantly different. Crumb characteristics were similar to control loaf, except bread with 10.0% tea fiber added. The control, bread with 2.5% and 5.0% had the same sensory parameters.ConclusionIn bread making, 2.5% of tea fiber can be recommended as a fiber‐enriching agent.Significance and noveltyThis paper shows the characterization of tea fiber and its effect on wheat flour and dough.
Scirrhous carcinoma: A previously undescribed tumor of the oral cavity
Authors: DeVries Jacquelyn , Finegersh Andrey , Gold Kathryn A. , Sharabi Andrew B. , Hu Jingjing , Orosco Ryan K. 
Published: May 2021

AbstractThis patient was found to have a scirrhous carcinoma with extensive perineural invasion and without any evidence of minor salivary gland carcinoma. To our knowledge, this is the first report of isolated scirrhous carcinoma of the oral cavity. Treatment was surgery and adjuvant chemoradiation, and there was complete disease response.
Primary tuberculosis of the parotid gland: A forgotten diagnosis about a case!
Authors: Benaissa Elmostafa , Bahalou Mohamed Habib , Safi Yassine , Bssaibis Fatna , Benlahlou Yasssine , Chadli Mariama , Maleb Adil , Elouennass Mostafa 
Published: May 2021

AbstractThe diagnosis of tuberculosis must be made in the face of any cervical swelling, and the treatment is essentially medical.
Interstitial 20p13 microdeletion including PRNP and adjacent genes in a fetus with congenital abnormalities—First case report
Authors: Onur Pelin , Shaver Mary , Iqbal Mohammed Anwaruddin 
Published: May 2021

AbstractWe present a prenatal case with congenital anomalies that revealed a 759 kb microdeletion at 20p13 possibly implicating PRNP and adjacent genes.
Permanent pacemaker implantation in a hemodialysis patient with subclavian vein occlusion using the balloon‐target puncture technique
Authors: Kasai Yuhei , Shakya Sandeep , Yamaura Takashi , Hayakawa Naoki , Miyaji Kotaro , Kanda Junji 
Published: May 2021

AbstractThe balloon‐target puncture technique is an effective method to secure the subclavian vein access route of cardiovascular implantable electronic devices.
Psychiatric care for a person with MELAS syndrome: A case report
Authors: Leong Douglas Yeung , Chee Rei Yen , Lui Yit Shiang 
Published: May 2021

AbstractThis report provides information for future clinicians who may be involved in treating patients with mitochondrial disorders manifesting with psychiatric problems, as literature in treatment is limited. The interventions focus on both carefully crafted medication therapy and nondrug methods to manage the challenging behaviors in a medically infirmed person.
Primary rhabdomyosarcoma of the ethmoid sinus with orbital extension and metastasis to the pancreatic body
Authors: Itamochi Hiroaki , Ariga Hisanori , Shiga Kiyoto , Uesugi Noriyuki , Sugai Tamotsu 
Published: May 2021

AbstractThis case report highlights the need for clinicians to monitor patients with rhabdomyosarcoma for pancreatic metastasis to ensure that proper treatment is quickly provided, thereby improving outcomes.
Dopant diffusion at the interface of TiO2‐MnO‐doped alumina/alumina layers in sintered laminates
Authors: Daniel Barros Marcelo , Hotza Dachamir , Janssen Rolf 
Published: May 2021

AbstractCeramic laminates were produced by thermal pressing of pure alumina (Al2O3) and TiO2‐MnO‐doped alumina (d‐Al2O3) tapes and subsequently sintered at temperatures ranging from 1100 to 1250°C. The diffusion of dopants through the interface was investigated by optical (OM), scanning electron (SEM) microscopy, nanoindentation, and energy‐dispersive X‐ray spectroscopy (EDS) together with scanning transmission electron microscopy. Temperature‐dependent dopant diffusion and porosity profiles were, respectively, observed investigating the microstructure. For d‐Al2O3, the average grain size, hardness, and Young's modulus were higher when compared to pure alumina, while the dopants diffusion zone presented intermediate values of these properties. The increase in sintering temperature resulted in higher values of hardness and Young's modulus in both layers. A further investigation showed a gradual decrease in grain size, hardness, and Young's modulus from the doped to the pure alumina layer, corresponding to a decreasing gradient in the dopants concentration in the Al2O3 layer with increasing distance from the interface. High concentrations of Mn and Ti were observed at triple points and grain boundaries, as well as within alumina grains.
Electrochemical Hydroboration of Alkynes
Authors: Aelterman Maude , Sayes Morgane , Jubault Philippe , Poisson Thomas 
Published: May 2021

AbstractHerein we reported the electrochemical hydroboration of alkynes by using B2Pin2as the boron source. This unprecedented reaction manifold was applied to a broad range of alkynes, giving the hydroboration products in good to excellent yields without the need of a metal catalyst or a hydride source. This transformation relied on the possible electrochemical oxidation of an in situ formed borate. This anodic oxidation performed in an undivided cell allowed the formation of a putative boryl radical, which reacted on the alkyne.
The role and histopathology of oral drug challenge in the evaluation of fixed drug eruptions
Authors: Vissing Megan Brinkworth , Bhasin Arveen , Sluzevich Jason 
Published: May 2021

AbstractThis case series describes the role of oral drug challenge in the diagnosis of fixed drug eruption in the setting of polypharmacy. Practical testing guidelines are provided. The literature describing the histopathology of acute fixed drug reaction is also reviewed and compared with the findings in this series.
NaWuReT‐Workshop: Forschung in der Reaktionstechnik für und mit der Gesellschaft
Authors: Börnhorst Marion , Friedland Jens , Kreitz Bjarne , Moioli Emanuele , Wehinger Gregor 
Published: May 2021

AbstractIm vorliegenden Artikel werden die Ergebnisse des NaWuReT‐Workshops (Nachwuchs Reaktionstechnik) aus dem Dezember 2020 zum Thema „Machen wir relevante Wissenschaft?“ vorgestellt. Nach Einführungs‐ und Übersichtsvorträgen wurden die Themen „(Un)überwindbare Hürden für Citizen Scientists in der Reaktionstechnik?“ und „Circular Economy in der Reaktionstechnik mit/für die Gesellschaft?“ diskutiert und vielfältige Ideen und Anregungen aus der Diskussion abgeleitet.
Non‐Destructive Three‐Dimensional Imaging of Metal Organic Framework Mixed Matrix Membranes using Lab‐based X‐ray Computed Tomography
Authors: Jansson Anton , Luz Ignacio , Chung Ching‐Chang , Soukri Mustapha 
Published: May 2021

AbstractTwo‐dimensional composites of metal particles and polymers hold the promise to enable revolutionary applications. The research and development of these films have been ongoing for over 60 years and new manufacturing and characterization techniques keep increasing the pace of advancements. Retrieving quantitative information from these types of samples can be a difficult and time‐consuming task when using line of sight imaging modalities. In this work a mixed‐matrix membrane with Co‐containing ZIF‐67 was studied with lab‐based X‐ray computed tomography. The benefits and limitations of what the computed tomography technique has to offer are presented and discussed.