bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta-Analysis of NUDT15 Genetic Polymorphism on Thiopurine-Induced Myelosuppression in Asian Populations
Authors: Khaeso Kanyarat , Udayachalerm Sariya , Komvilaisak Patcharee , Chainansamit Su-on , Suwannaying Kunanya , Laoaroon Napat , Kuwatjanakul Pitchayanan , Nakkam Nontaya , Sukasem Chonlaphat , Puangpetch Apichaya , Tassaneeyakul Wichittra , Chaiyakunapruk Nathorn 
Published: December 2021

Backgound: The high incidence of thiopurine-induced myelosuppression in Asians is known to be attributable to genetic variation in thiopurine metabolism. A quantitative synthesis to summarize the genetic association with thiopurine-induced myelosuppression in Asians was therefore conducted.Methods: A Literature search was performed from January 2016 to May 2021 in the following databases: PubMed, Web of Science, and Embase and addition search included the studies from Zhang et al. Two reviewers independently extracted the following data: the author’s name, year of publication, ethnicity, drugs, diseases, genetic polymorphisms, onset, type of myelosuppression and results of Hardy-Weinberg equilibrium. The Newcastle-Ottawa Scale was used to assess the quality of the studies. The pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated to evaluate the associations of NUDT15 and the risk of thiopurine-induced myelosuppression stratified by onset and type of myelosuppressive. Subgroup analysis by NUDT15 genetic polymorphisms was performed.Results: A total of 30 studies was included in this meta-analysis. The overall OR for the relationship between NUDT15 genetic polymorphisms and thiopurine-induced early onset of leukopenia and neutropenia in Asian populations were 11.43 (95% CI 7.11–18.35) and 16.35 (95% CI 10.20–26.22). Among NUDT15 polymorphisms, NUDT15*3 showed a significantly increased risk of early leukopenia (OR 15.31; 95% CI 9.65–24.27) and early neutropenia (OR 15.85; 95% CI 8.80–28.53). A significantly higher thiopurine-induced early neutropenic risk was also found for NUDT15*2 (OR 37.51; 95% CI 1.99–708.69). Whereas, NUDT15*5 and NUDT15*6 variants showed a lower risk of leukopenia.Conclusion: This study suggests that NUDT15*3 and NUDT15*2 are important genetic markers of thiopurine-induced early onset of myelotoxicity in Asians, therefore, early detection of these variants before initiating thiopurine therapy is necessary.
Kelvin-Helmholtz Instability Associated With Reconnection and Ultra Low Frequency Waves at the Ground: A Case Study
Authors: Kronberg E. A. , Gorman J. , Nykyri K. , Smirnov A. G. , Gjerloev J. W. , Grigorenko E. E. , Kozak L. V. , Ma X. , Trattner K. J. , Friel M. 
Published: December 2021

The Kelvin-Helmholtz instability (KHI) and its effects relating to the transfer of energy and mass from the solar wind into the magnetosphere remain an important focus of magnetospheric physics. One such effect is the generation of Pc4-Pc5 ultra low frequency (ULF) waves (periods of 45–600 s). On July 3, 2007 at ∼ 0500 magnetic local time the Cluster space mission encountered Pc4 frequency Kelvin-Helmholtz waves (KHWs) at the high latitude magnetopause with signatures of persistent vortices. Such signatures included bipolar fluctuations of the magnetic field normal component associated with a total pressure increase and rapid change in density at vortex edges; oscillations of magnetosheath and magnetospheric plasma populations; existence of fast-moving, low-density, mixed plasma; quasi-periodic oscillations of the boundary normal and an anti-phase relation between the normal and parallel components of the boundary velocity. The event occurred during a period of southward polarity of the interplanetary magnetic field according to the OMNI data and THEMIS observations at the subsolar point. Several of the KHI vortices were associated with reconnection indicated by the Walén relation, the presence of deHoffman-Teller frames, field-aligned ion beams observed together with bipolar fluctuations in the normal magnetic field component, and crescent ion distributions. Global magnetohydrodynamic simulation of the event also resulted in KHWs at the magnetopause. The observed KHWs associated with reconnection coincided with recorded ULF waves at the ground whose properties suggest that they were driven by those waves. Such properties were the location of Cluster’s magnetic foot point, the Pc4 frequency, and the solar wind conditions.
Preference, Knowledge, and Attitudes of Parents Toward Cognitive Behavioral Therapy for Their Children in Riyadh, Saudi Arabia
Authors: Alenezi Shuliweeh , Albawardi Ibrahim M. , Aldakhilallah Amirah , Alnufaei Ghaliah S. , Alshabri Rahaf , Alhamid Lama , Alotaiby Alanoud , Alharbi Norah 
Published: December 2021

Introduction:Cognitive behavioral therapy (CBT) for children and adolescents has shown efficacy in treating different psychiatric disorders. It has been added to multiple clinical guidelines as the first-line treatment. However, despite more studies of its efficacy, CBT is underutilized in clinical settings due to a lack of rigorous training programs and qualified CBT therapists. The limited knowledge of parents in this intervention and their negative attitudes toward it have been considered as possible reasons.Methods:This is a cross-sectional survey-based study among 464 Saudi parents living in Riyadh city. We aimed to evaluate the preference, knowledge, and attitudes of Saudi parents toward CBT for their children. We compared the difference in the level of knowledge and attitudes toward CBT in relation to the characteristics of parents. An online questionnaire that included 39 questions was carefully reconstructed from four validated scales, approved by an expert panel, and piloted. Participants were recruited to participate through online social media.Results:Saudi parents had average knowledge about CBT; however, they had positive attitudes toward the therapy itself and its role in treating the behavioral issues of children. Male participants showed better knowledge than female participants. Participants with higher education and those with high income had more favorable attitudes toward CBT than others.Conclusion:The knowledge of parents is considered inadequate and indicated the need for more awareness and perhaps mass education. In contrast, they maintained positive attitudes and were interested in evidence-based treatment, with more preference toward non-psychopharmacological interventions.
Improving Healthcare Worker Resilience and Well-Being During COVID-19 Using a Self-Directed E-Learning Intervention
Authors: Kelly Frances , Uys Margot , Bezuidenhout Dana , Mullane Sarah L. , Bristol Caitlin 
Published: December 2021

Introduction: High rates of burnout, depression, anxiety, and insomnia in healthcare workers responding to the COVID-19 pandemic have been reported globally.Methods: Responding to the crisis, the Foundation for Professional Development (FPD) developed an e-learning course to support healthcare worker well-being and resilience. A self-paced, asynchronous learning model was used as the training intervention. Each module included practical, skill-building activities. An outcome evaluation was conducted to determine if completing the course improved healthcare worker knowledge of and confidence in the learning outcomes of the course, their use of resilience-building behaviours, their resilience, and their well-being. A secondary objective was to explore if there were any associations between behaviours, resilience, and well-being. Participants completed pre- and post-course questionnaires to measure knowledge of and confidence in the learning outcomes, y, frequency of self-reported resilience-building behaviours, and levels of resilience (CD-RISC) and well-being (WHO-5). Results were analysed in STATA using paired T-tests, univariate and multivariate linear regression models.Results: Participants (n = 474; 77.6% female; 55.7% primary care) exhibited significant increases in knowledge, confidence, resilience-building behaviour, resilience, and well-being scores. Statistically significant improvements in the frequency of resilience-building behaviours led to significant improvements in resilience (0.25 points; 95% CI: 0.06, 0.43) and well-being (0.21 points; 95% CI: 0.05, 0.36). Increasing changes in well-being scores had a positive effect on change in resilience scores (β = 0.20; 95% CI: 0.11, 0.29), and vice versa (β = 0.28; 95% CI: 0.14, 0.41).Conclusion: A healthcare worker e-learning course can build knowledge and skills that may prompt changes in resilience-building behaviours and improvements in well-being and resilience scores. The findings suggest that e-learning courses may improve more than competency-based outcomes alone but further research is warranted to further explore these relationships.
Case Report: Robotically Assisted Excision of Cystic Tumor Located in a Difficult to Access Area in the Liver
Authors: Solomonov Evgeny , Tzadok Itamar , Biswas Seema 
Published: December 2021

Introduction: Cystic liver lesions may be benign cysts, parasitic infestations, or malignant tumors requiring surgical resection. Hilar location and relation to major vasculature present challenges in conventional surgical access and resection.Materials and Methods: We describe totally robotic excision of a cystadenoma in a 55-year-old woman without complication. Time points in the accompanying video (https://youtu.be/Tn_QPgpSHA4) are embedded within the text.Results: Advantages of the robotic technique lie in overcoming the natural restriction of conventional laparoscopic instruments, easier repair, and control of intraoperative vascular injuries using EndoWrist® instruments, ergonomic dissection close to major vasculature and reduced intraoperative blood loss as dissection is easier.Discussion: Indications for robotic surgery included the large size of the cystic lesion, its intrahepatic location, and compression of the inferior vena cava (IVC) and right and middle hepatic veins. Had robotic removal of the lesion not been feasible, the entire lobe of the liver would have required resection.
Comparison of Clinical Efficacy and Safety Between da Vinci Robotic and Laparoscopic Intersphincteric Resection for Low Rectal Cancer: A Meta-Analysis
Authors: Zhang Jie , Qi Xingshun , Yi Fangfang , Cao Rongrong , Gao Guangrong , Zhang Cheng 
Published: December 2021

Background and Aims: The intersphincteric resection (ISR) is beneficial for saving patients' anus to a large extent and restoring original bowel continuity. Laparoscopic ISR (L-ISR) has its drawbacks, such as two-dimensional images, low motion flexibility, and unstable lens. Recently, da Vinci robotic ISR (R-ISR) is increasingly used worldwide. The purpose of this article is to compare the feasibility, safety, oncological outcomes, and clinical efficacy of R-ISR vs. L-ISR for low rectal cancer.Methods: PubMed, EMBASE, Cochrane Library, and Web of Science were searched to identify comparative studies of R-ISR vs. L-ISR. Demographic, clinical, and outcome data were extracted. Mean difference (MD) and risk ratio (RR) with their corresponding confidence intervals (CIs) were calculated.Results: Five studies were included. In total, 510 patients were included, of whom 273 underwent R-ISR and 237 L-ISR. Compared with L-ISR, R-ISR has significantly lower estimated intraoperative blood loss (MD = −23.31, 95% CI [−41.98, −4.64], P = 0.01), longer operative time (MD = 51.77, 95% CI [25.68, 77.86], P = 0.0001), hospitalization days (MD = −1.52, 95% CI [−2.10, 0.94], P &lt; 0.00001), and postoperative urinary complications (RR = 0.36, 95% CI [0.16, 0.82], P = 0.02).Conclusions: The potential benefits of R-ISR are considered as a safe and feasible alternative choice for the treatment of low rectal tumors.
Trace Metal Accumulation and Phytoremediation Potential of Four Crop Plants Cultivated on Pure Sewage Sludge
Authors: Salinitro Mirko , Montanari Sofia , Simoni Andrea , Ciavatta Claudio , Tassoni Annalisa 
Published: December 2021

Phytoremediation is a viable strategy to remove trace metal contaminants from sewage sludge but still is poorly investigated. The aim of this study was to quantify the trace metal removal of B. napus, B. juncea, H. annuus, Z. mays grown on pure sewage sludge. Each species was grown on six different sewage sludge for 8 weeks and sludge were analysed for trace metal content and physico-chemical characteristics. Our results confirmed that all the tested sludge supported plant growth. The tested sludge showed a plant vigorousness lower (46% of sludge) or similar/increased (54% of sludge) compared to control treatment. B. juncea and B. napus were the most efficient species in the bioaccumulation, of trace metals. The average percentage of metals removed by the selected species was 0.2% for As, 0.85% for Cd, 0.09% for Cr, 0.36% for Cu, 0.36% for Ni, 4.2% for Se, 1.2% for Zn. In conclusion, our results showed that phytoremediation can be applied to sewage sludge, despite the chosen species have low efficiency in trace element removal. Further studies using hyperaccumulator species are needed which may lead to a higher efficiency of the process opening up new possibilities for the management strategies of this waste.
Riscos Associados ao Uso inadequado de Contraceptivos Hormonais – Revisão Sistemática / Risks Associated With the Inappropriate Use of Oral Hormonal Contraceptives
Authors: Da Silva Évila Daiana Coelho , Ayres Gibson Honório , Dos Santos Luanna Rebello de Souza , De Sousa Rayanne Pereira 
Published: December 2021

INTRODUÇÃO: A busca pelo método contraceptivo hormonal tem crescido substancialmente nos últimos 10 anos. Porém a utilização de medicamentos anticoncepcionais diante de quadros de comorbidade, como por exemplo, a hipertensão arterial, eleva os riscos de acidente vascular cerebral, infarto e outras doenças cardiovasculares. Além dessas doenças, o anticoncepcional oral também tem contraindicação diante de quadros de diabetes mellitus, trombose, enxaqueca.OBJETIVO: O objetivo deste projeto é Levantar evidências dos riscos associados ao uso inadequado de contraceptivos hormonais orais.MÉTODOS: Trata-se de uma revisão sistemática de estudo, publicados no período de 2010 a 2020 sobre o tema. Para o estudo utilizou-se pesquisa em bancos de dados, tais como: BVs (Biblioteca Virtual em Saúde) e a base de dados SCIELO (Scientific Eletronic Library Online), inserindo-se descritores específicos selecionados a partir da utilização da base DECs (Descritores em ciências da Saúde), sendo estes: Efeitos Adversos. Levonorgestrel. Etilenoestradiol. Progesterona. Anticoncepção Feminina. Planejamento Familiar. Atenção Farmacêutica.RESULTADOS: A partir dos descritores utilizados nas buscas, 114 artigos foram selecionados a partir das bases de dados, sendo 32 na plataforma Scielo, 70 na plataforma BVs e 12 no PubMed (base de dados alterantiva de busca). Destes, 10 artigos foram excluídos por duplicidade, restando 104 artigos (relatos rastreados). A partir deste número, 40 artigos foram excluídos por não condizerem com o tema eobjetivo proposto, sendo considerados 64 artigos a partir do critério de elegibilidade. Destes, 49 estavam fora do período pré-determinado para a pesquisa, restando 15 artigos finais, dentre os quais 11 são metanálise (pesquisa quantitativa) e 4 são de pesquisa qualitativa.CONCLUSÕES: Uma das maiores preocupações na atualidade é o controle da naalidade da população, impondo medidas preconizadas nos programas de saúde da mulher, como a distribuição de medicaments anticoncepcionais, especificamente em maior escala, os medicamentos orais. No entanto, a aquisição destes medicamentos, principalmente sem acompanhamento médico e mensurações clínicas adequadas acarretam doenças e complicações de saúde, como o desenvolvimento de doenças cardiovasculares, tromose, câncer de mama, agravamento do diabetes, dentre outros. Medicamentos como o desorgestrel e o levonorgestrel, por exemplo, culminam significativamente para a formação de trombos e coágulos. Outras combinações hormonais comumente encontradas nas pílulas anticoncepcionais diminuem efeitos de medicamentos hipoglicemiantes, aplicados no tratamento do Diabetes.
Analysis of the effect of ultrasound on Hymenaea courbaril L. seeds / Análise do efeito do ultrassom em sementes de Hymenaea courbaril L.
Authors: Dávila Luz Patricia Velásquez , Maggi Luis Eduardo , Pereira Wagner Coelho de Albuquerque , Rodriguez Anselmo Fortunato Ruiz , Ribeiro Ítalo Felipe Nogueira , Santos Isaac de Oliveira , Navarro Zandra Pilar Vela , Alves William Ferreira , Lacerda Rogério de Freitas , Silva Marcelo Castanheira da 
Published: December 2021

Hymenaea courbaril L. popularly known as Jatobá is a native species of the Amazon. We selected 100 seeds for the morphometric analysis, for the water content of the seeds, four samples of 5 g each were used, for the germination test, four groups of seeds were evaluated: control group without ultrasound application and three other groups that were submitted to ultrasound application for 2 minutes (U2), 3 minutes (U3) and 4 minutes (U4) at a frequency of 3 MHz and an intensity of 2 W/cm² of exposure. Each group divided into four repetitions of 25 seeds each, were transferred to an incubator (B.O.D.) with a photoperiod of 12 h of light per day and 100% relative humidity, each group being repeated twice and tested at two temperatures (30 °C and 35 °C). The seed has 9.36% fresh mass, 23.62 mm, 14.1 mm, 65.59 mm in length, width, and perimeter respectively and 79.03% purity. The ultrasound waves applied for 3 minutes favored seed germination of 86.12% (30 ºC) and 83.04% (35 ºC) and mean germination time of 21.75 days (30°C) and 21.81 days (35°C) for two and three minutes respectively. Therefore, the ultrasound technique is considered useful and promising tool for breaking tegumentary dormancy in Jatobá seeds.
Most involved microorganisms in foodborne diseases outbreaks: A systematic review / Microrganismos mais envolvidos em surtos de doenças transmitidas por alimentos: uma revisão sistemática
Authors: Do Prado Poliana Cristiane , Matias Carolina Laipelt , Goulart Juliana Querino , Pinto Andrea Troller 
Published: December 2021

Foodborne illnesses are caused by the ingestion of contaminated food and water and the main agents are biological. To identify the most related factors that are associated with these diseases, this study aimed to highlight the most frequently reported microorganisms in outbreaks, as well as the main foods involved and the causes of their contamination, present in publications from 2017 to 2021. Therefore, the search on the Web of Science platform was performed using the terms “foodborne diseases”, “foodborne outbreaks” and “foodborne illness”. The research's scope was restricted by associating “outbreak” to the others. As a result, the publications presented a greater number of foodborne outbreaks caused by Salmonella spp., Escherichia coli , Staphylococcus spp., Bacillus cereus and Vibrio spp., among bacteria. The most reported viruses were rotaviruses and noroviruses and the parasite Cyclospora spp. Among foods, it was clear that cattle and poultry meats were the most frequently reported. For causes of food contamination, it was observed that the lack of hygiene or care in food handling were the factors that most appeared among the studies. In conclusion, the adoption of stricter sanitary measures is necessary to reduce cases of FBDs, since many of them are related to procedures for handling unhygienic food.
Protocolos de biossegurança na odontologia durante a pandemia covid-19: revisão de literatura / Biosafety protocols in dentistry during the covid-19 pandemic: a literature review
Authors: Silva Ricardo da Silva , Lavareda Paloma Karine de Araújo , Rosa Marina Rolo Pinheiro da 
Published: December 2021

Diante da pandemia causada pelo novo coronavírus, as práticas de biossegurança tornam-se ainda mais importantes devido à exposição de riscos à saúde de profissionais e pacientes. Este trabalho, se propõe de uma revisão bibliográfica, com objetivo de verificar as condutas de biossegurança adotadas na prática odontológica com o surgimento da COVID-19. Foram pesquisados estudos primários e secundários, publicados no período de dezembro de 2017 a 2021, nas plataformas BBO, Lilac’s, PubMed, Scielo, Acervo Mais, Google Acadêmico, e afins. Na busca, foram utilizadas as palavras “dentistry”, “covid-19”, “coronavirus”, “dental practice”, “biosecurity” e “biosafety”. Os resultados demonstraram a necessidade de se utilizar enxaguatórios bucais pré-atendimento e minimizar produção de aerossóis com uso de diques de borracha e sucção de alta potência. Equipamentos de Proteção Individual (EPI) como protetores faciais e jalecos descartáveis devem ser acrescentados nos atendimentos, além da necessidade de maior controle na desinfecção de superfícies e adequações no ambiente odontológico. Conclui-se que, critérios mais rigorosos de biossegurança foram implementados na Odontologia com o surgimento da COVID-19. No entanto, ainda não existem evidências bem estabelecidas, apenas adaptações de protocolos e mecanismos instituídos em surtos epidêmicos anteriores, ocasionados por vírus semelhantes, como o SARS-CoV.
Dynamic analysis of the immunological response of Balb/c mice with experimental breast cancer submitted to immunotherapy treatment of dendritic cell/ Análise dinâmica da resposta imunológica de camundongos Balb/c com câncer de mama experimental submetido a imunoterapia de células dendríticas
Authors: Michelin Marcia Antoniazi , Murta Eddie Fernando Cândido , Silva Saulo Fernando Moreira da 
Published: December 2021

INTRODUCTION: Cancer is a complex disease because it is capable of inhibiting the immune response through tumor escape mechanisms. OBJECTIVE: analyze the dynamics of the immune system during cancer treatment with dendritic cell immunotherapy. We evaluated the presence of tumor infiltrate of CD8 T lymphocytes, transcription factors of CD4 T lymphocytes in the spleen of these animals, the development of tumor volume and the behavior of coestimulatory molecules. METHODS: 70 female Balb/c mice were divided into experimental and control groups, they were evaluated on the 7th e 14th days after tumor challenge and dendritic cell immunotherapy. RESULTS: Molecules such as T-bet, showed an increased expression in treated tumor group. Our results also demonstrated the higher MFI of CD8 + T lymphocytes infiltrate in the treated groups. Thus, there is a greater MFI of protumoral co-stimulatory molecules such as CTLA4 in the untreated groups. CONCLUSION: the immune system is able to modulate an immune response against tumor within 14 days if the organism is being treated with dendritic cell immunotherapy.