bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Preliminary Examination of the Impact of Working Memory Training on Syntax and Processing Speed in Children with ASD
Authors: Delage Hélène , Eigsti Inge-Marie , Stanford Emily , Durrleman Stephanie 
Published: November 2021

AbstractIn addition to deficits in pragmatics, children with autism spectrum disorders (ASD) have weaknesses in complex syntax and working memory (WM). These two deficits may be closely related. Previous work investigated the effects of WM training in developmental language disorders and showed significant improvement in both WM and syntax. The current study tests the impact of 12 h of WM training across 8 weeks in 30 children with ASD, aged 5 to 11. Results showed direct improvements on untrained WM tasks, as well as transfer effects to syntax and processing speed. Stronger WM led to better syntactic abilities. While they must be replicated, these exciting results provide impetus for further studies of WM interventions.
Caring for Children with an Autism Spectrum Disorder: Factors Associating with Health- and Care-Related Quality of Life of the Caregivers
Authors: ten Hoopen Leontine W. , de Nijs Pieter F. A. , Duvekot Jorieke , Greaves-Lord Kirstin , Hillegers Manon H. J. , Brouwer Werner B. F. , Hakkaart-van Roijen Leona 
Published: November 2021

AbstractThis study investigated the association of child, caregiver, and caregiving measurements with the quality of life (QoL) in 81 caregivers (mostly parents) of clinically referred children with autism spectrum disorder (ASD). We used the EuroQol five-dimensional (EQ-5D) questionnaire and the care-related QoL questionnaire (CarerQol) to respectively assess health-related QoL and care-related QoL. Health-related QoL was associated with the caregiver’s internalizing problems and adaptive coping, explaining 38% of the variance. Parenting stress and adaptive coping were associated with the care-related QoL and explained 60% of the variance. Child variables were not associated with the caregiver’s health- and care-related QoL if caregiver and caregiving variables were taken into account. Findings indicate the importance of the caregiver’s mental health, coping, and parenting stress in caring for children with ASD.
Cretaceous–Quaternary seismic stratigraphy of the Tanga offshore Basin in Tanzania and its petroleum potential
Authors: Mvile Benatus Norbert , Kiswaka Emily Barnabas , Osinowo Olawale Olakunle , Marobhe Isaac Muneji , Olayinka Abel Idowu , Mshiu Elisante Elisaimon 
Published: November 2021

AbstractIn this study, the available 2D seismic lines have been interpreted to understand the basin development and petroleum potential of the Late Cretaceous–Quaternary stratigraphy of the Tanga offshore Basin in Tanzania. Conventional seismic interpretation has delineated eight sedimentary fill geometries, fault properties, stratal termination patterns and unconformities characterizing the studied stratigraphy. The Late Cretaceous was found to be characterized by tectonic quiescence and uniform subsidence where slope induced gravity flows that resulted during the Miocene block movements was the major mechanism of sediment supply into the basin. The Quaternary was dominated by extensional regime that created deep N-S to NNE-SSW trending graben. The graben accommodated thick Pleistocene and Holocene successions deposited when the rate of tectonic uplift surpasses the rate of sea level rise. Thus, the deposition of lowstand system tracts characterized by debris flow deposits, slope fan turbidites, channel fill turbidites and overbank wedge deposits, known for their excellent petroleum reservoir qualities, especially where charged by Karoo Black Shales. Subsequent tectonic quiescence and transgression lead to the emplacement of deep marine deposits with characteristic seismic reflection patterns that indicate the occurrence of Quaternary shale sealing rocks in the study area. The occurrence of all the necessary petroleum play systems confirms the hydrocarbon generation, accumulations and preservation potential in the Tanga Basin.
Gas-generative potential for the post-Messinian megasequence of Nile Delta Basin: a case study of Tao Field, North Sinai Concession, Egypt
Authors: Sarhan Mohammad Abdelfattah 
Published: November 2021

AbstractThe main aim of the article is to evaluate the gas potentiality for the post-Messinian megasequence in TAO Field, North Sinai Concession, offshore Nile Delta Basin. The detailed petrophysical analysis for three deviated wells in the study area (Tao-3 ST1 Well, Tao-5 STA Well and Tao-7 Well) revealed that the Pliocene Kafr El-Sheikh Formation includes eleven gas-bearing zones. These zones were named: A, B, C in Tao-3 ST1 Well and D, E, F in Tao-5 STA Well. In Tao-7 Well, the interesting zones are named G, H, I, J and K. All of these sandy intervals are relatively shallow in depth and differ in thickness between 4 and 56 m. These zones are characterized by shale volume (10%), total porosity (30–40%), effective porosity (30–35%), gas saturation (50–90%), high effective permeability to gas and low permeability to water. The seismic data displayed that listric faults and the associated rollover folds have an important role in forming structural traps for the examined gas-bearing zones in Tao Field and its surroundings. This work revealed that the success rate in discovering new gas prospects within the Pliocene–Pleistocene succession at North Sinai Concession is very high.
Cholera, British seamen and maritime anxieties in Calcutta, c.1830s–1890s ‘The William Bynum Prize Essay’
Authors: Dutta Manikarnika 
Published: November 2021

AbstractFrom the mid-nineteenth century, seamen were increasingly identified as vectors of epidemic diseases such as cholera. The rising acceptance of the germ theories of disease and contagion and the transition from sail to steam at this time increased the fear of the rapid spread of contagious diseases through these mobile people. This article examines how the British naval authorities, ship surgeons and the medical and municipal authorities in the Calcutta sailortown sought to improve maritime health and hygiene to prevent the spread of cholera among and by British seamen. Nineteenth century Calcutta is an ideal context for this study on account of its epidemiological notoriety as a disease entrepot and the sea route between Calcutta and British ports was one of the most closely monitored for disease in the Empire. The article argues that a study of cholera among British seamen can generate important insights into the relationship among disease, medicine and colonialism and in doing so shed light into a neglected aspect of the history of nineteenth century cholera, the British anxiety regarding disease dispersion, practice of hygiene and sanitation and British seamen’s health.
Mapping Total Exceedance PM2.5 Exposure Risk by Coupling Social Media Data and Population Modeling Data
Authors: Cao Zheng , Guo Guanhua , Wu Zhifeng , Li Shaoying , Sun Hui , Guan Wenchuan 
Published: November 2021

AbstractThe PM2.5 exposure risk assessment is the foundation to reduce its adverse effects. Population survey‐related data have been deficient in high spatiotemporal detailed descriptions. Social media data can quantify the PM2.5 exposure risk at high spatiotemporal resolutions. However, due to the no‐sample characteristics of social media data, PM2.5 exposure risk for older adults is absent. We proposed combining social media data and population survey‐derived data to map the total PM2.5 exposure risk. Hourly exceedance PM2.5 exposure risk indicators based on population modeling (HEPEpmd) and social media data (HEPEsm) were developed. Daily accumulative HEPEsm and HEPEpsd ranged from 0 to 0.009 and 0 to 0.026, respectively. Three peaks of HEPEsm and HEPEpsd were observed at 13:00, 18:00, and 22:00. The peak value of HEPEsm increased with time, which exhibited a reverse trend to HEPEpsd. The spatial center of HEPEsm moved from the northwest of the study area to the center. The spatial center of HEPEpsd moved from the northwest of the study area to the southwest of the study area. The expansion area of HEPEsm was nearly 1.5 times larger than that of HEPEpsd. The expansion areas of HEPEpsd aggregated in the old downtown, in which the contribution of HEPEpsd was greater than 90%. Thus, this study introduced various source data to build an easier and reliable method to map total exceedance PM2.5 exposure risk. Consequently, exposure risk results provided foundations to develop PM2.5 pollution mitigation strategies as well as scientific supports for sustainability and eco‐health achievement.
Syn‐Shearing Deformation Mechanisms of Minerals in Partially Molten Metapelites
Authors: Dutta Dripta , Misra Santanu , Mainprice David 
Published: November 2021

AbstractWe investigated an experimentally sheared (γ = 15, = 3 × 10−4 s−1, 300 MPa, 750°C) quartz‐muscovite aggregate to understand the deformation of parent and new crystals in partially molten rocks. The scanning electron microscope and electron backscatter diffraction analyses along the longitudinal axial section of the cylindrical sample suggest that quartz and muscovite melted partially and later produced K‐feldspar, ilmenite, biotite, mullite, and cordierite. Quartz grains became finer, and muscovite was almost entirely consumed in the process. With increasing γ, melt and crystal fractions decreased and increased, respectively. Among the new minerals, K‐feldspar grains (highest area fraction and coarsest) nucleated first, whereas cordierite and mullite grains, finest and least in number, respectively, nucleated last. Fine grain size, weak crystallographic preferred orientations, low intragranular deformation, and equant shapes suggest both initial and new minerals deformed dominantly by melt‐assisted grain boundary sliding, which is further substantiated by higher misorientations between adjacent grains of quartz, K‐feldspar, and ilmenite.
Defining the Internal Component of Atlantic Multidecadal Variability in a Changing Climate
Authors: Deser Clara , Phillips Adam S. 
Published: November 2021

AbstractThe canonical index of “Atlantic Multidecadal Variability” (AMV) is the low‐pass filtered timeseries of sea surface temperature anomalies (SSTA) averaged over the North Atlantic. This index and its associated SSTA spatial pattern confound externally forced climate change and internally generated climate variability. The internal component of AMV is commonly isolated by either subtracting the global‐mean SSTA or removing the pattern of SSTA associated with the global‐mean. This study evaluates the skill of each method with regard to the spatial pattern of internal AMV, using nine coupled model Large Ensembles over the period 1940–2100 as a testbed in which the true internal AMV is known a priori. The first method aliases the structure of forced climate change onto internal AMV, while the second method is generally robust to climate change. The models simulate realistic patterns of internal AMV, although such an assessment is hampered by the brevity of the observational record.
The Influence of Gas Hydrate Morphology on Reservoir Permeability and Geophysical Shear Wave Remote Sensing
Authors: Sahoo Sourav K. , Best Angus I. 
Published: November 2021

AbstractWe show that direct estimates of the permeability of hydrate‐bearing geological formations are possible from remote measurements of shear wave velocity (Vs) and attenuation (Qs−1). We measured Vs, Qs−1 and electrical resistivity at time intervals during methane hydrate formation in Berea sandstone using a laboratory ultrasonic pulse‐echo system. We observed that Vs and Qs−1 both increase with hydrate saturation Sh, with two peaks in Qs−1 at hydrate saturations of around 6% and 20% that correspond to changes in gradient of Vs. We implemented changes in permeability with hydrate saturation into well‐known Biot‐type poro‐elastic models for two‐ and three‐phases for low (Sh < 12%) and high (Sh > 12%) hydrate saturations respectively. By accounting for changes in permeability linked to hydrate morphology, the models were able to describe the Vs and Qs−1 observations. We found that the first Qs−1 peak is caused by a reduction of permeability during hydrate formation associated with a transition from pore‐floating to pore‐bridging hydrate morphology; similarly, the second Qs−1 peak is caused by a permeability reduction associated with a transition from pore‐bridging hydrate morphology to an interlocking network of hydrate in the pores. We inverted for permeability using our poro‐elastic models from Vs and Qs−1. This inverted permeability agrees with permeability obtained independently from electrical resistivity. We demonstrate a good match of our models to shear wave data at 200 Hz and 2 kHz frequencies from the literature, indicating the general applicability of the models.
Influence of Orography Upon Summertime Low‐Level Jet Dust Emission in the Central and Western Sahara
Authors: Caton Harrison Thomas , Washington Richard , Engelstaedter Sebastian , Jones Richard G. , Savage Nick H. 
Published: November 2021

AbstractLow‐level jets (LLJs) drive frequent emission of mineral dust in the central and western Sahara in boreal summer. A major hotspot for this process is central Algeria, northern Mali and Mauritania, through which blow the dry near‐surface northeasterly Harmattan winds, with a peak in dust emission around the low‐lying Tidihelt region. North African orography is thought to contribute to the strength of the LLJ over the Bodele dust source in Chad, but its influence on erosivity over summertime source regions remains unquantified. In this paper, the contribution of central Saharan orography to the strength of Harmattan LLJs and associated dust emission frequency is tested. An idealized simulation with flattened Hoggar mountains is compared with a control using the Met Office Unified Model at 12 km horizontal resolution. In the absence of the Hoggar mountains, dust emission frequency estimated using an empirical relationship with surface wind speeds is found to decline across the entire northeasterly “LLJ alley,” including by 31% in the Tidihelt where composited jet surface winds drop from 9.0 to 7.3 m s−1 under a more easterly regime. The mountains are linked to a low‐level leeward geopotential height perturbation, with a northern limb reinforcing northeasterlies through the Tidihelt. Dome‐shaped elevated heating situated over the Hoggar mountains explains the difference between the simulated wind fields in the two experiments. These findings suggest that central Saharan orography plays an important role in sustaining erosive dusty conditions during boreal summer.
Aerosol Activation in Radiation Fog at the Atmospheric Radiation Program Southern Great Plains Site
Authors: Wainwright Charlotte , Chang Rachel Y.‐W. , Richter David 
Published: November 2021

AbstractEnvironmental supersaturation is a key parameter in the formation of fog and clouds, yet it cannot be measured directly and must be inferred. Calculating the ambient supersaturation in fog requires knowledge of the aerosol hygroscopicity as well as particle size distribution, and relatively few values have been reported in the literature. Here we use κ‐Köhler theory to derive aerosol activation properties based on particle hygroscopicity and dry particle size distributions, and then estimate the effective peak supersaturation during eight cases of radiative fog at the Southern Great Plains site in rural north‐central Oklahoma, USA. The mean hygroscopicity parameter κ of particles likely to act as cloud condensation nuclei varied from 0.14 to 0.43. Ambient effective peak supersaturation during the fog episodes was between 0.01%–0.07%, with most values below 0.04%. The minimum 50% dry activation diameter generally ranged between 300–400 nm with little activation of particles with diameters below 300 nm.
“Ryanopathies” and RyR2 dysfunctions: can we further decipher them using in vitro human disease models?
Authors: Sleiman Yvonne , Lacampagne Alain , Meli Albano C. 
Published: November 2021

AbstractThe regulation of intracellular calcium (Ca2+) homeostasis is fundamental to maintain normal functions in many cell types. The ryanodine receptor (RyR), the largest intracellular calcium release channel located on the sarco/endoplasmic reticulum (SR/ER), plays a key role in the intracellular Ca2+ handling. Abnormal type 2 ryanodine receptor (RyR2) function, associated to mutations (ryanopathies) or pathological remodeling, has been reported, not only in cardiac diseases, but also in neuronal and pancreatic disorders. While animal models and in vitro studies provided valuable contributions to our knowledge on RyR2 dysfunctions, the human cell models derived from patients’ cells offer new hope for improving our understanding of human clinical diseases and enrich the development of great medical advances. We here discuss the current knowledge on RyR2 dysfunctions associated with mutations and post-translational remodeling. We then reviewed the novel human cellular technologies allowing the correlation of patient’s genome with their cellular environment and providing approaches for personalized RyR-targeted therapeutics.
The MdABI5 transcription factor interacts with the MdNRT1.5/MdNPF7.3 promoter to fine-tune nitrate transport from roots to shoots in apple
Authors: Liu Ya-Jing , Gao Ning , Ma Qi-Jun , Zhang Jiu-Cheng , Wang Xun , Lu Jing , Hao Yu-Jin , Wang Xiao-Fei , You Chun-Xiang 
Published: November 2021

AbstractNitrate is a major nitrogen resource for plant growth and development and acts as both a crucial nutrient and a signaling molecule for plants; hence, understanding nitrate signaling is important for crop production. Abscisic acid (ABA) has been demonstrated to be involved in nitrate signaling, but the underlying mechanism is largely unknown in apple. In this study, we found that exogenous ABA inhibited the transport of nitrate from roots to shoots in apple, and the transcription of the nitrate transporter MdNRT1.5/MdNPF7.3 was noticeably reduced at the transcriptional level by ABA, which inhibited the transport of nitrate from roots to shoots. Then, it was found that the ABA-responsive transcription factor MdABI5 bound directly to the ABRE recognition site of the MdNRT1.5 promoter and suppressed its expression. Overexpression of MdABI5 inhibited ABA-mediated transport of nitrate from roots to shoots. Overall, these results demonstrate that MdABI5 regulates the transport of nitrate from roots to shoots partially by mediating the expression of MdNRT1.5, illuminating the molecular mechanism by which ABA regulates nitrate transport in apple.
Understanding how Victoria, Australia gained control of its second COVID-19 wave
Authors: Trauer James M. , Lydeamore Michael J. , Dalton Gregory W. , Pilcher David , Meehan Michael T. , McBryde Emma S. , Cheng Allen C. , Sutton Brett , Ragonnet Romain 
Published: November 2021

AbstractDuring 2020, Victoria was the Australian state hardest hit by COVID-19, but was successful in controlling its second wave through aggressive policy interventions. We calibrated a detailed compartmental model of Victoria’s second wave to multiple geographically-structured epidemic time-series indicators. We achieved a good fit overall and for individual health services through a combination of time-varying processes, including case detection, population mobility, school closures, physical distancing and face covering usage. Estimates of the risk of death in those aged ≥75 and of hospitalisation were higher than international estimates, reflecting concentration of cases in high-risk settings. We estimated significant effects for each of the calibrated time-varying processes, with estimates for the individual-level effect of physical distancing of 37.4% (95%CrI 7.2−56.4%) and of face coverings of 45.9% (95%CrI 32.9−55.6%). That the multi-faceted interventions led to the dramatic reversal in the epidemic trajectory is supported by our results, with face coverings likely particularly important.
Experimental quantum simulation of superradiant phase transition beyond no-go theorem via antisqueezing
Authors: Chen Xi , Wu Ze , Jiang Min , Lü Xin-You , Peng Xinhua , Du Jiangfeng 
Published: November 2021

AbstractThe superradiant phase transition in thermal equilibrium is a fundamental concept bridging statistical physics and electrodynamics, which has never been observed in real physical systems since the first proposal in the 1970s. The existence of this phase transition in cavity quantum electrodynamics systems is still subject of ongoing debates due to the no-go theorem induced by the so-called A2 term. Moreover, experimental conditions to study this phase transition are hard to achieve with current accessible technology. Based on the platform of nuclear magnetic resonance, here we experimentally simulate the occurrence of an equilibrium superradiant phase transition beyond no-go theorem by introducing the antisqueezing effect. The mechanism relies on that the antisqueezing effect recovers the singularity of the ground state via exponentially enhancing the zero point fluctuation of system. The strongly entangled and squeezed Schrödinger cat states of spins are achieved experimentally in the superradiant phase, which may play an important role in fundamental tests of quantum theory and implementations of quantum metrology.
Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis
Authors: Kawahara Rebeca , Chernykh Anastasia , Alagesan Kathirvel , Bern Marshall , Cao Weiqian , Chalkley Robert J. , Cheng Kai , Choo Matthew S. , Edwards Nathan , Goldman Radoslav , Hoffmann Marcus , Hu Yingwei , Huang Yifan , Kim Jin Young , Kletter Doron , Liquet Benoit , Liu Mingqi , Mechref Yehia , Meng Bo , Neelamegham Sriram , Nguyen-Khuong Terry , Nilsson Jonas , Pap Adam , Park Gun Wook , Parker Benjamin L. , Pegg Cassandra L. , Penninger Josef M. , Phung Toan K. , Pioch Markus , Rapp Erdmann , Sakalli Enes , Sanda Miloslav , Schulz Benjamin L. , Scott Nichollas E. , Sofronov Georgy , Stadlmann Johannes , Vakhrushev Sergey Y. , Woo Christina M. , Wu Hung-Yi , Yang Pengyuan , Ying Wantao , Zhang Hui , Zhang Yong , Zhao Jingfu , Zaia Joseph , Haslam Stuart M. , Palmisano Giuseppe , Yoo Jong Shin , Larson Göran , Khoo Kai-Hooi , Medzihradszky Katalin F. , Kolarich Daniel , Packer Nicolle H. , Thaysen-Andersen Morten 
Published: November 2021

AbstractGlycoproteomics is a powerful yet analytically challenging research tool. Software packages aiding the interpretation of complex glycopeptide tandem mass spectra have appeared, but their relative performance remains untested. Conducted through the HUPO Human Glycoproteomics Initiative, this community study, comprising both developers and users of glycoproteomics software, evaluates solutions for system-wide glycopeptide analysis. The same mass spectrometry based glycoproteomics datasets from human serum were shared with participants and the relative team performance for N﻿- and O-glycopeptide data analysis was comprehensively established by orthogonal performance tests. Although the results were variable, several high-performance glycoproteomics informatics strategies were identified. Deep analysis of the data revealed key performance-associated search parameters and led to recommendations for improved ‘high-coverage’ and ‘high-accuracy’ glycoproteomics search solutions. This study concludes that diverse software packages for comprehensive glycopeptide data analysis exist, points to several high-performance search strategies and specifies key variables that will guide future software developments and assist informatics decision-making in glycoproteomics.