bluuebunny/crossref_metadata_2025_split huggingface dataset:
Occult Andersson lesions in patients with ankylosing spondylitis: undetectable destructive lesions on plain radiographs
Authors: Huang Ji-Chen , Qian Bang-Ping , Qiu Yong , Wang Bin , Yu Yang , Zhao Shi-Zhou 
Published: June 2021

Abstract

Background:
Andersson lesions (ALs) are not uncommon in ankylosing spondylitis (AS). Plain radiography (PR) is widely used for the diagnosis of ALs. However, in our practice, there were some ALs in AS patients that could not be detected on plain radiographs. This study aimed to propose the concept of occult ALs and evaluate the prevalence and radiographic characteristics of the occult ALs in AS patients.

Methods:
A total of 496 consecutive AS patients were admitted in the Affiliated Drum Tower Hospital, Medical School of Nanjing University between April 2003 and November 2019 and they were retrospectively reviewed. The AS patients with ALs who met the following criteria were included for the investigation of occult ALs: (1) with pre-operative plain radiographs of the whole-spine and (2) availability of pre-operative computed tomography (CT) and/or magnetic resonance imaging (MRI) of the whole-spine. The occult ALs were defined as the ALs which were undetectable on plain radiographs but could be detected by CT and/or MRI. The extensive ALs involved the whole discovertebral junction or manifested as destructive lesions throughout the vertebral body. Independent-samples t test was used to compare the age between the patients with only occult ALs and those with only detectable ALs. Chi-square or Fisher exact test was applied to compare the types, distribution, and radiographic characteristics between detectable and occult ALs as appropriate.

Results:
Ninety-two AS patients with a mean age of 44.4 ± 10.1 years were included for the investigation of occult ALs. Twenty-three patients had occult ALs and the incidence was 25% (23/92). Fifteen extensive ALs were occult, and the proportion of extensive ALs was significantly higher in detectable ALs (97% vs. 44%, χ
2 = 43.66, P < 0.001). As assessed by PR, the proportions of osteolytic destruction with reactive sclerosis (0 vs. 100%, χ
2 = 111.00, P < 0.001), angular kyphosis of the affected discovertebral units or vertebral body (0 vs. 22%, χ
2 = 8.86, P = 0.003), formation of an osseous bridge at the intervertebral space adjacent to ALs caused by the ossification of the anterior longitudinal ligament (38% vs. 86%, χ
2 = 25.91, P < 0.001), and an abnormal height of the affected intervertebral space were all significantly lower in occult ALs (9% vs. 84%, χ
2 = 60.41, P < 0.001).

Conclusions:
Occult ALs presented with more subtle radiographic changes. Occult ALs should not be neglected, especially in the case of extensive occult ALs, because the stability of the spine might be severely impaired by these lesions.
Analysis of related factors affecting cumulative live birth rates of the first ovarian hyperstimulation in vitro fertilization or intracytoplasmic sperm injection cycle: a population-based study from 17,978 women in China
Authors: Yang Rui , Niu Zi-Ru , Chen Li-Xue , Liu Ping , Li Rong , Qiao Jie 
Published: June 2021

Abstract

Background:
More and more scholars have called for the cumulative live birth rate (CLBR) of a complete ovarian stimulation cycle as a key indicator for assisted reproductive technology. This research aims to study the CLBR of the first ovarian hyperstimulation cycles and analyze the related prognosis factors that might affect the CLBR.

Methods:
Our retrospective study included first in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) cycles performed between January 2013 to December 2014. A total of 17,978 couples of first ovarian hyperstimulation IVF/ICSI cycles were included. The study was followed up for 4 years to observe the CLBR. The multivariable logistic regression model was used to analyze the prognosis factor, P value of <0.05 was considered statistically significant.

Results:
The cumulative pregnancy rate was 58.14% (10,452/17,978), and the CLBR was 49.66% (8928/17,978). The female age was younger in the live birth group when compared with the non-live birth group (30.81 ± 4.05 vs. 33.09 ± 5.13, P < 0.001). The average duration of infertility was shorter than the non-live birth cohort (4.22 ± 3.11 vs. 5.06 ± 4.08, P < 0.001). The preliminary gonadotropin used and the total number of gonadotropin used were lower in the live birth group when compared with the non-live birth group (both P < 0.001). Meanwhile, the number of oocytes retrieved and transferrable embryos were both significantly higher in the live birth group (15.35 ± 7.98 vs. 11.35 ± 7.60, P < 0.001; 6.66 ± 5.19 vs. 3.62 ± 3.51, P < 0.001, respectively).

Conclusions:
The women's age, body mass index, duration of infertility years, infertility factors, controlled ovarian hyperstimulation protocol, the number of acquired oocytes, and number of transferrable embryos are the prognosis factors that significantly affected the CLBR.
Clinical Characteristics and Outcomes of Eosinophilic Colitis in Patients With Cancer
Authors: Khurana Shruti , Abu-Sbeih Hamzah , Ma Weijie , Qiao Wei , Foo Wai Chin , Richards David M. , Thomas Anusha S. , Khan Anam , Zhang Hao Chi , Wang Yinghong 
Published: June 2021

Background:
Eosinophilic colitis (EoC) is a rare form of eosinophilic gastrointestinal disease characterized by diffuse eosinophilic infiltration in the deep lamina propria of colonic mucosa. The pathophysiology is unclear, but EoC has been associated with multiple known risk factors.

Aim:
The aim of this study was to characterize the clinical characteristics and disease course of patients with EoC at a major cancer center.

Material and Methods:
We retrospectively reviewed colonic samples obtained between January 2000 and December 2018 from our institutional database and included cases with significant colonic eosinophilia. Baseline clinical data and EoC-related clinical course and outcomes were documented.

Results:
Forty-one patients were included. One fourth had coexisting autoimmune conditions. Seventy-eight percent had a cancer diagnosis. Half the patients received chemotherapy, with a median duration of 180 days between chemotherapy and EoC onset. Symptoms were present in 76% of patients. Diarrhea was more prevalent in patients who received chemotherapy (85% vs. 42%). Median duration of EoC symptoms was 30 days in patients with cancer and 240 days in those without cancer (P=0.03). Most patients (88%) had normal colonoscopy findings. Fifteen percent of patients required hospitalization. All-cause mortality was 37%, mostly related to underlying malignancy and organ failure.

Conclusions:
EoC in cancer patients appears to have more diarrhea-predominant symptoms, particularly in patients receiving chemotherapy, but a shorter disease duration compared with patients without cancer. Hospitalization can be required for serious cases. Treatment may be reserved for patients requiring symptom management, as most patients with EoC have good clinical outcomes regardless of treatment.
Small-incision lenticule extraction in the U.S. military: prospective study of visual and military task performance
Authors: Sia Rose K. , Ryan Denise S. , Beydoun Hind , Eaddy Jennifer B. , Logan Lorie A. , Rodgers Samantha B. , Rivers Bruce A. 
Published: June 2021

Purpose:
To assess early visual outcomes and military task performance after small-incision lenticule extraction (SMILE) among U.S. military service members.

Setting:
Warfighter Refractive Eye Surgery Program and Research Center and Night Vision and Electronic Sensors Directorate, Fort Belvoir, Virginia.

Design:
Single-center, prospective, observational study.

Methods:
The study was composed of active duty service members (n = 37) electing to undergo SMILE for myopia or myopic astigmatism. Testing performed preoperatively and at 1 month and 3 months postoperatively included uncorrected (UDVA) and corrected (CDVA) distance visual acuities, wavefront aberrometry, low-contrast visual acuity (LCVA), contrast sensitivity, and vision-related questionnaire. 14 participants underwent rifle marksmanship with spectacle correction before and without correction at 6 to 8 weeks postoperatively.

Results:
At 3 months postoperatively, the efficacy index was 0.96 and the safety index was 1.03. UDVA was ≥20/20 in 69 (96%) of eyes. LCVA change from baseline was significant under night vision condition. Eye problems contributed to 10% work and 20% activity impairments, both of which decreased to 0% (P = .001). The overall satisfaction rating for SMILE was high at 90.9 (95% CI, 85.3 to 96.5), and 95% of participants would be willing to undergo the procedure again. The median scores between preoperative and 6 to 8 weeks postoperative firing performance were comparable (34 vs 35, with and without correction, respectively; P = .247).

Conclusions:
After the early recovery period, SMILE seems to preserve quality of vision, which appears to facilitate the accomplishment of tasks related to their work as military service members as well as performing activities outside of work.
Prevalence of Adult Female Genital Trauma After Acute Sexual Assault
Authors: McNair Susan M. , Boisvert Leslie 
Published: June 2021

ABSTRACT

Background
Examination of the adult female genitalia after an acute sexual assault may reveal findings interpreted by the examiner as injuries, which may be linked to later legal outcomes. There is no consistent definition in the literature regarding what findings constitute genital trauma after sexual assault. We studied how the prevalence of genital trauma is impacted by the inclusion/exclusion of various genital findings reported in the literature.

Methods
A retrospective descriptive chart review of the sexual assault forensic records from a provincial regional sexual assault treatment center was conducted over a 4-year period and included 67 female patients, 12 years old and over, who reported being sexually assaulted in the previous 72 hours and received a complete forensic examination. We studied the prevalence of genital trauma, using eight definitions of trauma, as well as the percentage of each type of genital finding within this population.

Results
The prevalence of genital trauma in this population ranged from 52%, the majority, to 31% of women, depending on the definition of trauma utilized. Forty-one percent of the findings, the greatest number overall, were redness. Bruises, abrasions, and tears (lacerations), the components of blunt force trauma, accounted for 4%, 15%, and 14% of the findings, respectively.

Interpretation
A universal definition of what findings constitute genital trauma after acute sexual assault is required if the examiner, as expert witness, is to compare findings in a given case with the broader literature and assist the court in ensuring an informed process of decision making.
Workshift Changes in Hydration Status During Wildfire Suppression
Authors: Rosales Alejandro M. , Dodds Patrick S. , Sol Joseph A. , Marks Alexander N. , Domitrovich Joseph W. , Ruby Brent C. 
Published: June 2021

Objective:
Document wildland firefighters (WLFFs) hydration status during a singular workshift (13.7 ± 1.4 hours).

Methods:
WLFF researchers documented real-time WLFF (n = 71) urine metrics and fluid consumption. Body weight and blood samples (n = 25) were also collected. Two-tailed dependent t tests determined statistical significance (P < 0.05).

Results:
Body weight significantly decreased (−0.3 ± 1.1%, P > 0.05). Fluid consumption totaled 6.2 ± 2.3 L including food and 5.0 ± 2.1 L without food. Morning versus afternoon urine frequency (2.6 ± 1.3, 3.1 ± 1.9 voids), urine volume (1.2 ± 0.7, 1.3 ± 0.8 L), urine volume per void (440 ± 157, 397 ± 142 mL), and urine specific gravity (1.010 ± 0.007, 1.010 ± 0.007) were not significantly different (P > 0.05). Pre- to post-workshift serum chloride (103.2 ± 1.9, 101.4 ± 1.7 mM) and blood glucose (5.2 ± 0.4, 4.5 ± 0.7 mM) significantly decreased (P < 0.05), while serum sodium (141.5 ± 2.4, 140.8 ± 2.0 mM) and serum potassium (4.3 ± 0.3, 4.2 ± 0.3 mM) remained stable (P > 0.05).

Conclusions:
WLFFs can ingest fluid and food amounts that maintain workshift euhydration and electrolyte status.
How Managers Find Out About Common Mental Disorders Among Their Employees
Authors: Bertilsson Monica , Klinkhammer Stephanie , Staland-Nyman Carin , de Rijk Angelique 
Published: June 2021

Objective:
To explore how managers find out about common mental disorders (CMDs) among employees and associations with managers’ work- and knowledge-related characteristics and attitude to CMDs.

Methods:
Data from an online survey in 2017 with Swedish managers (n = 1810) were used. Different ways managers find out about CMDs were measured, and multivariate logistic regression analysis was conducted for associations with manager characteristics.

Results:
Few managers found out about CMDs themselves; another source was more common, for example, employees’ self-disclosure. Managers’ overseeing fewer subordinates and those with a negative attitude to depression were more likely to find out about CMDs themselves. The significance of mental health training and education could not be established.

Conclusion:
Managers’ awareness about employees’ CMDs mainly came about through employees’ self-disclosure. Managers’ attitudes and work conditions were related to the way of finding out.
Increasing Family Education and Support Opportunities
Authors: Tvedte Matthew J. , Henaghan Amelia S. , Nandivada Prathima , Dickie Belinda Hsi 
Published: June 2021

Introduction
The medical and surgical care of individuals diagnosed with an anorectal malformation (ARM) has become increasingly standardized with greater attention to the importance of holistic and long-term treatment approaches. Development of opportunities for social connection and peer support among individuals diagnosed with an ARM and their families is a valuable contribution to care for this population. The desire to increase these types of opportunities in our center led to the development of a family education and peer support day for individuals with ARM and their families.

Methods
We identify and describe five priorities for event development: (a) securing hospital and center-based leadership support, (b) maximizing family input, (c) limiting financial burden, (d) maintaining an interdisciplinary approach, and (e) building on existing connections.

Results
A 1-day event was developed, which included educational presentations, Question and Answer with an expert panel, group discussion, and group activities. The event was attended by 42 participants including 28 caregivers, 12 patients, and two siblings, representing 18 distinct family groups. Overall feedback for the event (response rate: 50%) was positive.

Discussion
The development of a family education and support event was found to be a valuable experience for providers, patients, and families. Families appeared to benefit from both the education provided and the opportunity to engage with others with similar lived experiences. Implications for future events include greater emphasis on opportunities for peer connections, greater emphasis on the adolescent experience, and expansion of included diagnoses.
The Effect of Ostomy on Pediatric Patient and Family in Nursing
Authors: Uzsen Hatice , Yaz Seyda Binay , Gumus Merve 
Published: June 2021

Aim
This study aimed to examine the studies on children with stoma/ostomy in the field of nursing in terms of nursing science.

Method
This was a qualitative research based on a document analysis of the studies, and it was designed as a systematic review. It was carried out in accordance with the Centre for Reviews and Dissemination guide. The databases of EBSCOhost, PubMed, Science Direct, Google Scholar, and Web of Science were searched between January 2010 and October 2020, and the studies on ostomy in pediatric patients were examined. The search was conducted by using the English keywords including “ostomy/stoma, children, nursing care.” Inclusion and exclusion criteria to select studies were determined based on the PICOS method (P = populations, I = interventions, C = comparison, O = outcomes, and S = study type). Data were extracted by two researchers independently. All studies were examined in full text, and it was decided which studies to include in the systematic review.

Results
In this study, 9,857 studies were found by entering the keywords in the first search. Among these, 87 studies were selected when their titles, abstracts, and keywords were examined. By the inclusion criteria, 20 studies from the EBSCOhost, PubMed, Scopus, Google Scholar, and Science Direct databases were included in the study.

Conclusion
It was observed that the most common studies were the ones that were investigating the problems experienced by the children with an ostomy and their parents and its effects on them. It has been suggested that this systematic review will form a base for the experimental or randomized controlled studies that are needed in the field of ostomy and make a contribution to the literature.
Measuring Recovery With Ecological Momentary Assessment in a Randomized Trial of Exercise After Sport-Related Concussion
Authors: Wiebe Douglas J. , Storey Eileen P. , Orchinik Julia E. , Grady Matthew F. , Leddy John J. , Willer Barry S. , Haider Mohammad Nadir , Mannix Rebekah , Meehan William P. , Vernau Brian T. , Master Christina L. 
Published: June 2021

Objective:
Investigate the reliability of concussion symptoms captured through ecological momentary assessment (EMA) and compare time with recovery based on 3 definitions of symptomatic recovery and the date of clinical clearance to begin the return-to-play (RTP) process.

Design:
We used a mobile app with EMA to monitor concussion symptoms as part of a multicenter randomized controlled trial.

Setting:
Three sports medicine practices.

Participants:
Patients between 13 and 18 years old with sport-related concussion were prompted to complete the Post-Concussion Symptom Inventory daily over 4 weeks.

Interventions:
None.

Main Outcome Measures:
We compared the elapsed days to reaching the 4 outcomes using scatterplots and Kaplan–Meier curves.

Results:
Among 118 participants, symptoms reported into the app had excellent agreement with symptoms reported at a clinical visit on the same day (intraclass correlation coefficient = 0.97). Most (>50%) participants reached “specific symptom return to preinjury levels,” “overall symptom return to preinjury levels,” and “current symptom resolution” based on EMA symptom reports between several days and 1 week before achieving “clinical clearance to RTP” determined at a clinical visit, which had 100% sensitivity, but between 56.3% and 78.1% specificity, relative to the app-measured symptom outcomes.

Conclusions:
Time until symptom recovery varies based on the chosen definition of symptomatic recovery but is a more precise correlate with clinical clearance to begin the RTP process when defining symptom recovery as a return to a preinjury baseline level of symptomatology. Real-time symptom monitoring may be beneficial clinically, allowing providers to assess patients' recovery status and make more timely and remote treatment recommendations.
Psychological effects of traditional Chinese mind-body exercises for low back pain
Authors: Huang Qian , Lu Xiaonian , He Tianxiang , Du Juan , Zhang Peiguo 
Published: June 2021

Abstract

Introduction:
Several studies reported that traditional Chinese mind-body exercises showed beneficial effects on improving anxiety and depression of patients with low back pain (LBP) in recent years. However, the effects of traditional Chinese mind-body exercises on improving psychological disorders of patients with LBP remain controversial. Most previous reviews only focused on the effects of traditional Chinese mind-body exercises for LBP on pain and dysfunction. Therefore, the present systematic review and meta-analysis will be conducted to evaluate the evidence on psychological effects of traditional Chinese mind-body exercises for LBP.

Methods and analysis:
The electronic databases (PubMed, Embase, MEDLINE, Cochrane Central Register of Controlled Trials, Web of Science, China Knowledge Resource Integrated Database, and Wanfang Data) will be searched. The search will include all documents from their inception to February 2021. The Physiotherapy Evidence Database scale will be used for quality assessment of eligible studies. Risk of bias of eligible studies will also be assessed by Cochrane tool. The meta-analysis will be conducted using the Review Manager Version 5.3 software. The Higgins I

2
statistic will be performed to examine for heterogeneity. The subgroup analysis will be conducted based on different types of traditional Chinese mind-body exercises, different intervention time, and different outcomes. Quality of evidence will be assessed using the Grades of Recommendation, Assessment, Development and Evaluation.

Ethics and dissemination:
No ethical statement will be required for the performance of this review and meta-analysis. The results of this review will be published in an international peer-reviewed journal.

INPLASY registration number:
INPLASY202130075.
Analgesia effects of IPACK block added to multimodal analgesia regiments after total knee replacement
Authors: Wang Feng , Ma Wenming , Huang Zhihui 
Published: June 2021

Abstract

Background:
Currently, no meta-analysis exists elucidate the analgesic effect of adding IPACK block to our current multimodal analgesia regimen after total knee replacement (TKR). The purpose of this study is to systematically review the level I evidence in the literature to ascertain whether IPACK block can bring additional analgesic benefits to existing multimodal analgesia regimens.

Methods:
The systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Only level I randomized controlled trials (RCTs) were included in our study. The primary outcome was the pain scores with rest and activity. Secondary outcomes included cumulative opioid consumption, cumulative distance ambulated, and length of stay (LOS).

Results:
Five RCTs with a total of 467 patients were included. The most important finding in our study was that although IPACK block supplementation improved pain scores at 12 hours with rest or activity after surgery, no such benefit was observed at subsequent time points during the postoperative period. Interestingly, IPACK supplementation did not reduce opioid consumption, especially in the first 24 hours after surgery. Furthermore, other postoperative outcomes, including cumulative distance ambulated and LOS, were also not improved by the addition of an IPACK.

Conclusions:
The addition of an IPACK block to multimodal analgesia regiments does not reduce the postoperative opioid consumption nor improve functional performance. However, it may be an appropriate method to improve immediate analgesic effects after TKR.