bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utilizations and outcomes of intra‐arterial balloon occlusion at cesarean hysterectomy for placenta accreta spectrum
Authors: Matsuo Koji , Matsuzaki Shinya , Vestal Nicole L. , Sangara Rauvynne N. , Mandelbaum Rachel S. , Matsushima Kazuhide , Klar Maximilian , Ouzounian Joseph G. 
Published: October 2021

AbstractIntroductionThis study examined national‐level trends, characteristics, and perioperative outcomes of women who had intra‐arterial balloon occlusion at cesarean hysterectomy for placenta accreta spectrum (PAS).Material and methodsThis was a population‐based retrospective observational study that queried the National Inpatient Sample from October 2015 to December 2018. Study population was women who underwent hysterectomy at cesarean delivery for PAS (n = 6440 in 806 centers). Exposure allocation was the use of intra‐arterial balloon occlusion. Main outcome measures were (a) characteristics associated with intra‐arterial balloon occlusion use, and (b) perioperative outcome including hemorrhage, blood transfusion, coagulopathy, shock, urinary tract injury, intra‐arterial balloon occlusion‐related complication (arterial injury, arterial thrombosis, and lower extremities ischemia), and death, assessed in multivariable analysis.ResultsIntra‐arterial balloon occlusion was used in 420 (6.5%) women in 64 (7.9%) centers. Utilization of intra‐arterial balloon occlusion during cesarean hysterectomy for placenta accreta decreased significantly over time (from 6.3% to 3.1%, p < 0.001), but not in placenta increta (from 12.8% to 9.3%, p = 0.204) or placenta percreta (from 21.3% to 17.5%, p = 0.344). In a multivariable analysis, patient factors (younger age, earlier year, obesity, diabetes mellitus), pregnancy factors (placenta increta/percreta, previous cesarean delivery, placenta previa, and early gestational age), and facility factors (large bed capacity, urban teaching status, and Northeast/West regions) represented the independent characteristics for using the intra‐arterial balloon occlusion (all, p < 0.05). In a classification‐tree model, the absolute difference in intra‐arterial balloon occlusion use among 18 utilization patterns was 48% (range, 0%–48%). In perioperative outcome analysis, women who received intra‐arterial balloon occlusion were more likely to have coagulopathy (adjusted odds ratio [aOR] 3.43) and arterial thrombosis (aOR 9.82) in placenta accreta, but less likely to have hemorrhage (aOR 0.25) in placenta increta, and blood transfusion (aOR 0.60) and urinary tract injury (aOR 0.28) in placenta percreta compared with those who did not (all, p < 0.05).ConclusionsThere is a wide range in the utilization of intra‐arterial balloon occlusion at cesarean hysterectomy for PAS based on patient, pregnancy, and facility factors, which implies that there is a lack of universal practice guidelines in this surgical procedure. Whether the use of intra‐arterial balloon occlusion in the severe forms of PAS improves surgical outcome merits further investigation.
The influence of political partisanship on perceptions of sexual assault
Authors: Naseralla Eyad J. , Baker S. Glenn , Warner Ruth H. 
Published: October 2021

AbstractAcross three studies, we examined the role of victim, perpetrator, and observer political orientation in judgments of sexual assault allegations. Study 1A varied the political orientation of the alleged perpetrator, whereas Study 1B varied the political orientation of the alleged victim. Study 2 varied the political orientation of both the alleged victim and perpetrator. In Studies 1A, 1B, and 2, Republican participants reported more rape‐supportive attitudes than Democratic participants overall. In Study 2, Republican participants showed more rape‐supportive attitudes, especially when the perpetrator was Republican or when the victim was Democratic. Additionally, both Democratic and Republican participants felt that the allegations may have been politically motivated when the alleged perpetrator's political orientation matched their own. Results provide evidence that political orientation plays a role in judgments of sexual assault, a factor which appears to be more prevalent among Republicans.
Addressing anhedonia to increase depression treatment engagement
Authors: Khazanov Gabriela K. , Forbes Courtney N. , Dunn Barnaby D. , Thase Michael E. 
Published: October 2021

Anhedonia, or reward system dysfunction, is associated with poorer treatment outcomes among depressed individuals. The role of anhedonia in treatment engagement, however, has not yet been explored. We review research on components of reward functioning impaired in depression, including effort valuation, reward anticipation, initial responsiveness, reward learning, reward probability, and reward delay, highlighting potential barriers to treatment engagement associated with these components. We then propose interventions to improve treatment initiation and continuation by addressing deficits in each component of reward functioning, focusing on modifications of existing evidence‐based interventions to meet the needs of individuals with heightened anhedonia. We describe potential settings for these interventions and times at which they can be delivered during the process of referring individuals to mental health treatment, conducting intakes or assessments, and providing treatment. Additionally, we note the advantages of using screening processes already in place in primary care, workplace, school, and online settings to identify individuals with heightened anhedonia who may benefit from these interventions. We conclude with suggestions for future research on the impact of anhedonia on treatment engagement and the efficacy of interventions to address it.Practitioner points

Many depressed individuals who might benefit from treatment do not initiate it or discontinue early. One barrier to treatment engagement may be anhedonia, a core symptom of depression characterized by loss of interest or pleasure in usual activities.

We describe brief interventions to improve treatment engagement in individuals with anhedonia that can be implemented during the referral process or early in treatment.

We argue that interventions aiming to improve treatment engagement in depressed individuals that target anhedonia may be particularly effective.
Meaningful response criteria for myelodysplastic syndromes
Authors: Kim Nina , Pavletic Steven , Norsworthy Kelly J. 
Published: October 2021

SummaryStandardizing response criteria for myelodysplastic syndromes (MDS), a clinically and biologically heterogeneous group of disorders, has been historically challenging. The International Working Group (IWG) response criteria, first proposed in 2000 and modified in 2006 and 2018, represent the best effort by a group of international experts to define a set of clinically meaningful end‐points in MDS. These criteria have been adopted in many MDS clinical trials, allowing for comparisons of response across trials. However, clinical experience has also revealed some limitations of these criteria, and most of the end‐points proposed by the IWG require further validation. In this review, we present a critical analysis of the current MDS response criteria from both a practical standpoint and based on currently available clinical trial data. Potential areas for improvement in the criteria are highlighted, which may be considered in future iterations of the response criteria.
Ovarian carcinoma immunoreactive antigen domain 2 controls mitochondrial apoptosis in lung adenocarcinoma
Authors: Hong Jeongmin , Shiba‐Ishii Aya , Kim Yunjung , Noguchi Masayuki , Sakamoto Noriaki 
Published: October 2021

AbstractOvarian carcinoma immunoreactive antigen domain 2 (OCIAD2) has been reported to show significantly higher expression in invasive lung adenocarcinoma than in lung adenocarcinoma in situ, and its abnormal expression is associated with poorer prognosis of the patients. However, the cellular function of OCIAD2 in this tumor remains poorly understood. In the present study, we first validated that OCIAD2 showed higher expression in human lung adenocarcinoma tissues or cell lines than in normal lung tissue or immortalized normal bronchial epithelial cells. OCIAD2 was localized predominantly at the mitochondrial membrane in lung adenocarcinoma cells. Interestingly, suppression of OCIAD2 led to loss of mitochondrial structure and a reduction in the number of mitochondria. Moreover, OCIAD2 suppression led to downregulation of cellular growth, proliferation, migration, and invasion, and upregulation of mitochondria‐related apoptosis. We also showed that OCIAD2 suppression induced a decrease in mitochondrial membrane potential and release of cytochrome c. Transcriptional profiling using RNA sequencing revealed a total of 137 genes whose expression was commonly altered after OCIAD2 knockdown in three lung adenocarcinoma cell lines (A549, HCC827, and PC9). Pathway enrichment analysis of those genes demonstrated significant enrichment in apoptotic signaling or endoplasmic reticulum (ER) stress pathways. Our data suggest that OCIAD2 inhibits the mitochondria‐initiated apoptosis and thus promotes the survival of lung cancer cells. Therefore, OCIAD2 may be an effective target for treatment of lung adenocarcinoma.
Electroacupuncture promotes the survival and synaptic plasticity of hippocampal neurons and improvement of sleep deprivation‐induced spatial memory impairment
Authors: Pei Wenya , Meng Fanqi , Deng Qingwen , Zhang Baobao , Gu Yuan , Jiao Boyu , Xu Haoyu , Tan Jiuqing , Zhou Xin , Li Zhiling , He Guanheng , Ruan Jingwen , Ding Ying 
Published: October 2021

AbstractAimsThis study aimed to investigate whether electroacupuncture (EA) promotes the survival and synaptic plasticity of hippocampal neurons by activating brain‐derived neurotrophic factor (BDNF)/tyrosine receptor kinase (TrkB)/extracellular signal‐regulated kinase (Erk) signaling, thereby improving spatial memory deficits in rats under SD.MethodsIn vivo, Morris water maze (MWM) was used to detect the effect of EA on learning and memory, at the same time Western blotting (WB), immunofluorescence (IF), and transmission electron microscopy (TEM) were used to explore the plasticity of hippocampal neurons and synapses, and the expression of BDNF/TrkB/Erk signaling. In vitro, cultured hippocampal neurons were treated with exogenous BDNF and the TrkB inhibitor K252a to confirm the relationship between BDNF/TrkB/Erk signaling and synaptic plasticity.ResultsOur results showed that EA mitigated the loss of hippocampal neurons and synapses, stimulated hippocampal neurogenesis, and improved learning and memory of rats under SD accompanied by upregulation of BDNF and increased phosphorylation of TrkB and Erk. In cultured hippocampal neurons, exogenous BDNF enhanced the expression of synaptic proteins, the frequency of the postsynaptic currents, and the phosphorylation of TrkB and Erk; these effects were reversed by treatment with K252a.ConclusionsElectroacupuncture alleviates SD‐induced spatial memory impairment by promoting hippocampal neurogenesis and synaptic plasticity via activation of BDNF/TrkB/Erk signaling, which provided evidence for EA as a therapeutic strategy for countering the adverse effects of SD on cognition.
Dermatofibrosarcoma protuberans with platelet‐derived growth factor‐D rearrangement; two cases with morphologically distinct presentations
Authors: Campbell Katelynn , Bridge Julia A. , DiMaio Dominick , Wilson Janice , Shalin Sara C. , Gardner Jerad M. 
Published: October 2021

AbstractDermatofibrosarcoma protuberans (DFSP) is a mesenchymal neoplasm that is usually located in the dermis or subcutis and is locally aggressive. Rarely, these lesions may undergo fibrosarcomatous transformation, which is thought to increase their metastatic potential. DFSP is classically associated with a 17;22 translocation (or ring chromosome thereof) resulting in fusion of the COL1A1 and PDGFB genes. However, variant fusions involving PDGFD have been recently reported. Herein, we present two morphologically diverse cases of DFSP with PDGFD rearrangement. Case 1 is a 68‐year‐old female with a left dorsal foot lesion. Morphologically, the lesion is unusual as it is a well‐circumscribed, hypercellular, subcutaneous nodule with uniform CD34‐positive spindle cells arranged in a herringbone pattern without storiform arrangement or “honeycombing” fat entrapment. It was diagnosed as pure fibrosarcomatous DFSP. Case 2 is a 37‐year‐old male with a right supra‐auricular lesion. Morphologically, the lesion displays classic DFSP features including bland CD34‐positive spindle cells with storiform growth, fat entrapment, and infiltrative borders. Both lesions were negative for COL1A1‐PDGFB fusion but positive for PDGFD rearrangement by fluorescence in situ hybridization (FISH) analysis. FISH testing for PDGFD rearrangement should be performed in cases where there is a high suspicion for DFSP but initial studies for COL1A1‐PDGFB are negative.
BRAF‐rearranged spindle cell mesenchymal neoplasm with a predominant lipofibromatosis‐like neural tumor pattern and co‐expression of CD34, S100 protein, and markers associated with perineurial differentiation: A rare case with potential diagnostic pitfall
Authors: Sun Ke , Ru Guo‐qing , Zhao Ming 
Published: October 2021

AbstractRecently, a distinctive group of S100 protein/CD34‐positive spindle cell mesenchymal neoplasms characterized by a predominant lipofibromatosis‐like neural pattern harboring recurrent gene rearrangements involving NTRK1‐3, RAF1, RET, ROS1, ALK, and MET has been identified. BRAF rearrangements have been rarely documented in this group of neoplasms. Herein, we report a 54‐year‐old man with a 1.3‐cm painless mass located in the subcutis of left back. The tumor was composed of mildly atypical, short‐spindle shaped to ovoid cells with fascicles and whorls intervening between and admixed with the subcutaneous adipose tissues and nerve bundles. Focally abundant thick, band‐like stromal hyalinization was also noted. The neoplastic cells showed diffuse reactivity for S100 protein and CD34 and multifocal immunopositivity for markers associated with perineurial differentiation including epithelial membrane antigen, GLUT1, and claudin‐1. Fluorescence in situ hybridization analyses showed positive for BRAF rearrangement and negative for rearrangements involving NTRK1, RET, and ROS1. The tumor was narrowly excised and recurred after 24 months of follow‐up. To our knowledge, we report the second case of BRAF‐rearranged spindle cell mesenchymal tumor with predominant lipofibromatosis‐like neural tumor pattern. Expression of markers associated with perineurial differentiation is exceptional and represents a potential diagnostic pitfall, which may cause significant diagnostic confusion with a peripheral nerve sheath tumor.
Curatorial Omissions in Virtual War Museum Displays: Uncovering Racial and Gendered Tensions in Canadian WWI Exhibitions
Authors: Pauls Haley , Walby Kevin 
Published: October 2021

AbstractThis paper investigates how virtual exhibitions curated by the Canadian War Museum (CWM) and the Canadian Centre for the Great War (CCGW) communicate ideas about nationalism and multiculturalism in Canada. Drawing from critical literature on participatory museum spaces, multiculturalism, and hegemony, we examine how virtual war exhibitions, which attempt to create space for marginalized identities, may inadvertently reinforce hegemonic understandings of Canadian identity. Through our analysis of two case studies, we explore how digital curation, while offering visitors a sense of participation, may also sanitize resistant perspectives. This analysis allows us to examine present‐day Canadian multiculturalism as it is communicated in digital museum curations, including its practice of including racialized others on a conditional basis, its weaponization of white feminist narratives, and its continued investments in the history of English and French Canada as universal. We thus examine the way Canadian nationalism re‐makes itself, and how virtual curatorial techniques, which may seem more inclusive, can serve hegemonic ends. This study should be of interest to curators and designers working in digital contexts, as well as scholars studying multiculturalism as it is pictured in museums, media, and other cultural representations.
Documentation of psoriasis in routine care – expert consensus on a German data set
Authors: Otten Marina , Mrowietz Ulrich , von Kiedrowski Ralph Michael , Otto Ramona , Altenburg Andreas , Aschoff Roland , Beissert Stefan , Beiteke Ulrike , Bonnekoh Bernd , Hoffmann Matthias , Körber Andreas , Maaßen Dirk , Mössner Rotraut , Navarini Alexander , Petering Holger , Ramaker‐Brunke Jutta , Rosenbach Thomas , Schwichtenberg Uwe , Sticherling Michael , Sondermann Wiebke , Thaci Diamant , Timmel Andreas , Tsianakas Athanasios , Werfel Thomas , Wilsmann‐Theis Dagmar , Augustin Matthias 
Published: October 2021

SummaryBackground and objectivesDocumenting patient data in psoriasis clinical practice can improve care, but standardized and transparent documentation is rare. The current project aimed to develop a data set for the documentation of psoriasis in daily practice.Material and methodsIn four online Delphi rounds and one in‐person meeting, 27 psoriasis experts allocated variables to a standard, an optimal and an optional data set. Most of the questions were standardized. Open questions were included to allow for the provision of reasons and to enlarge the data sets. Furthermore, in the in‐person meeting we considered a) patients’ attitudes and b) dermatologists’ information on the current usage and acceptability in Germany.ResultsThe consensus approach resulted in a data set with 69 variables. The standard data set includes 20, the optimal data set 31 and the optional data set 18 variables. In summary, the data set can mainly be grouped into master data, general status and medical history data, medical history of psoriasis, status of psoriasis, diagnostics and comorbidity, therapies and patient‐reported outcomes.ConclusionsThe consensus recommendation of a standard, an optimal and an optional data set for routine care of psoriasis intends to be a decision‐making aid and an orientation for both daily practice and further development of documentation systems.
Top 10 acral skin manifestations associated with COVID‐19: A scoping review
Authors: Farajzadeh Saeedeh , Khalili Maryam , Dehghani Shakiba , Babaie Sharareh , Fattah Mahdi , Abtahi‐Naeini Bahareh 
Published: October 2021

AbstractCOVID‐19‐associated cutaneous manifestations are one of the most important and relatively common extra‐respiratory presentations of SARS‐COV‐2 infection. The exact identification and classification of these lesions can facilitate the accurate diagnosis and treatment. There are several case reports and small case series which describe cutaneous lesions in hands and feet. Currently, there is no scoping review about acral skin manifestations associated with COVID‐19. This paper covers the COVID‐related acral skin manifestations in 10 entities including acral papulo‐vesicular eruption, acral urticarial lesion, acral non‐inflammatory purpura and necrosis, acro‐ischemia associated COVID‐19, acral vasculitis, chilblain‐like lesion (COVID Toe), acral erythema multiform (EM) like lesion, hand and foot skin lesions associated with multisystem inflammatory syndrome in children (MISC), acral peeling conditions and red half‐moon nail sign. Future studies should focus on exact investigation of etiologies of these lesions including role of immune senescence, environment, gender, immunogenetics and relation of these lesion with major organ involvements.
Experiencing the a priori
Authors: Seron Denis 
Published: October 2021

AbstractBrentano clearly asserts, in his Vienna lectures of 1887–1888, that his descriptive psychology is an a priori or “exact” science. Since he rejects Kant's idea of a synthetic a priori, this means that the descriptive psychologist's laws are analytic. My aim in this paper is to clarify and discuss this view. I examine Brentano's epistemology in the Psychology from an Empirical Standpoint and then its later developments. I conclude with a difficulty inherent in Brentano's psychological approach to a priori knowledge.
Restoring Skyline Tier: Decommissioning pine plantations in Tasmania
Authors: Dudley Todd , Morgan Helen , Povey Anna , Fitzgerald Nick 
Published: October 2021

Unerring prediction of potential to facilitate native regeneration at clearcut pine plantations provided a strong basis for this collaborative project between forest resources companies and environmentalists. The resulting recovery of nearly 700 ha of native forest to date has allowed unlikely partners to reach their goals as well as create some lasting social benefits for a range of stakeholders. Restore Skyline Tier aspires to restore 2,160 ha of Radiata Pine plantation back to native forest, with the methods transferrable to other sites.
Continuous seizure emergency evoked in mice with pharmacological, electrographic, and pathological features distinct from status epilepticus
Authors: Knox Kevin M. , Zierath Dannielle K. , White H. Steve , Barker‐Haliski Melissa 
Published: October 2021

SummaryObjectivesBenzodiazepines are the standard of care for the management of sustained seizure emergencies, including status epilepticus (SE) and seizure clusters. Seizure clusters are a variably defined seizure emergency wherein a patient has multiple seizures above a baseline rate, with intervening periods of recovery, distinguishing clusters from SE. Although these seizure emergencies are phenotypically distinct, the precise pathophysiological and mechanistic differences between SE and seizure clusters are understudied. Emergency‐specific preclinical models may differentiate the behavioral and pathological mechanisms that are acutely associated with seizure emergencies and seizure termination to better manage these events.MethodsHerein we characterize a novel model of sustained seizure emergency induced in CF‐1 mice through the combined administration of high‐dose phenytoin (PHT; 50 mg/kg, i.p.) and pentylenetetrazol (PTZ; 100 mg/kg, s.c.).ResultsWe presently describe a mouse model of sustained seizure emergency that is pathologically, pharmacologically, and behaviorally distinct from SE. Acute administration of PHT 1 h prior to PTZ led to significantly more mice with unremitting continuous seizure activity (CSA; 73.4%) vs vehicle‐pretreated mice (13.8%; p < .0001). CSA was sensitive to lorazepam and valproic acid when administered at seizure onset and 30 minutes later. Carbamazepine worsened seizure control and post‐CSA survival. Mice in CSA exhibited electroencephalography (EEG) patterns distinct from kainic acid–induced SE and PTZ alone, clearly differentiating CSA from SE and PTZ‐induced myoclonic seizures. Neuropathological assessment by Fluoro‐Jade C staining of brains collected 24 h post‐CSA revealed no neurodegeneration in any mouse that underwent CSA, whereas there was widespread neuronal death in brains from KA‐SE mice. Finally, immunohistochemistry revealed acute seizure‐induced astrogliosis (glial fibrillary acid protein; GFAP) in hippocampal structures, whereas hippocampal neuronal nuclei (NeuN) protein expression was only reduced in KA‐SE mice.SignificanceWe present a novel mouse model on which to further elucidate the mechanistic differences between sustained seizure emergencies (ie, SE and seizure clusters) to improve clinical interventions and define mechanisms of seizure termination.