bluuebunny/crossref_metadata_2025_split huggingface dataset:
An acute viral hepatitis epidemic: does ultrasound help the pediatrician?
Authors: Arooj Sadaf , Mukhtar Muhammad Umer , Abbas Farnaz 
Published: March 2021

Abstract
Objective
Acute viral hepatitis (AVH) caused by hepatitis virus A and hepatitis virus E is one of the many epidemics that plague third world countries like Pakistan. The serological tests required for the diagnosis of acute viral hepatitis may be unavailable or unaffordable to the denizens of a developing country like Pakistan. In such a scenario, the clinical manifestations and the ultrasonographic findings are the only diagnostic criteria usually present and these can be used to support a clinical diagnosis. This study aims to judge the utility of ultrasound in the diagnosis of AVH.

Results
Among the forty-seven subjects of this study, gall bladder wall thickening (GWT) was the most common radiological finding seen in 39 (82.9%) patients. Pericholecystic edema was the second most common finding, seen in 31 (65.9%) patients. Starry sky appearance of the liver was observed in 30 (63.8) patients. Hepatomegaly and ascites were seen in 28 (59.5%) and 25 (53.2%) of the patients, respectively. The ultrasonographic findings of GWT, pericholecystic edema, and starry sky appearance of the liver were the most common ultrasonographic findings associated with AVH.
Characterization, stability and hyperstability of multi-quadratic–cubic mappings
Authors: Bodaghi Abasalt , Fošner Ajda 
Published: March 2021

AbstractIn this paper, we unify the system of functional equations defining a multi-quadratic–cubic mapping to a single equation. Applying a fixed point theorem, we study the generalized Hyers–Ulam stability of multi-quadratic–cubic mappings. As a result, we investigate the hyperstability of multi-quadratic–cubic mappings in some senses.
The first initial-boundary value problem of parabolic Monge–Ampère equations outside a bowl-shaped domain
Authors: Dai Limei , Cheng Huihui 
Published: March 2021

AbstractIn this paper, we study the parabolic Monge–Ampère equations $-u_{t}\det (D^{2}u)=g$
−

u
t

det
(

D
2

u
)
=
g
outside a bowl-shaped domain with g being the perturbation of $g_{0}(|x|)$

g
0

(
|
x
|
)
at infinity. Under the weaker conditions compared with the problem outside a cylinder, we obtain the existence and uniqueness of viscosity solutions with asymptotic behavior for the first initial-boundary value problem by using the Perron method.
Existence and uniqueness results on time scales for fractional nonlocal thermistor problem in the conformable sense
Authors: Agarwal P. , Sidi Ammi M. R. , Asad J. 
Published: March 2021

AbstractWe study a conformable fractional nonlocal thermistor problem on time scales. Under an appropriate nonrestrictive condition on the resistivity function, we establish existence and uniqueness results. The proof is based on the use of Schauder’s point fixed theorem.
Experimental Study on Basic Mechanical Properties of Core-Column Non-mortar Aerated Concrete Block Masonry
Authors: Pi Tianxiang , Du Zhongheng , Zhang Huchen , Wang Sicheng 
Published: March 2021

AbstractAutoclaved aerated concrete (AAC) block masonry has been widely used for bearing walls of multi-story buildings or non-bearing walls of high-rise buildings because of its unique advantages, such as lightweight, low pollution output, and excellent thermal insulation performance. However, traditional AAC block masonry has the disadvantages of high water absorption, poor adhesion to mortar, and low construction efficiency. In order to improve the performance of traditional AAC masonry, this paper proposed a new kind of mortar-free AAC block masonry with concrete core-columns. Fundamental mechanical properties of compression and shear were studied. We divided a total of 16 compression specimens into four groups according to different hollow ratios and strength grades of the block, and eight shear specimens into two groups based on different hollow ratios. Each specimen consists of three-layer blocks with two core columns at the point of quadri-section. The diameters of columns were, respectively, 100 mm and 80 mm. The specimens were loaded at a constant speed to evaluate their bearing capacity, displacement response, crack development, and damage state. The formula of the average values and design values of the compressive and shear strength of masonry were obtained statistically. The stress–strain constitutive relation of masonry expressed by a three-stage curve was presented. Furthermore, the result of numerical analysis using the ABAQUS finite element program aligned well with the experimental results. The compressive strength and shear strength of the new type of masonry are no less than traditional AAC masonry, and new masonry has higher construction efficiency and more stable strength.
Transcriptomic analysis reveals the molecular mechanisms of rumen wall morphological and functional development induced by different solid diet introduction in a lamb model
Authors: Sun Daming , Yin Yuyang , Guo Changzheng , Liu Lixiang , Mao Shengyong , Zhu Weiyun , Liu Junhua 
Published: March 2021

Abstract
Background
This study aimed to elucidate the molecular mechanisms of solid diet introduction initiating the cellular growth and maturation of rumen tissues and characterize the shared and unique biological processes upon different solid diet regimes.

Methods
Twenty-four Hu lambs were randomly allocated to three groups fed following diets: goat milk powder only (M, n = 8), goat milk powder + alfalfa hay (MH, n = 8), and goat milk powder + concentrate starter (MC, n = 8). At 42 days of age, the lambs were slaughtered. Ruminal fluid sample was collected for analysis of concentration of volatile fatty acid (VFA) and microbial crude protein (MCP). The sample of the rumen wall from the ventral sac was collected for analysis of rumen papilla morphology and transcriptomics.

Results
Compared with the M group, MH and MC group had a higher concentration of VFA, MCP, rumen weight, and rumen papilla area. The transcriptomic results of rumen wall showed that there were 312 shared differentially expressed genes (DEGs) between in “MH vs. M” and “MC vs. M”, and 232 or 796 unique DEGs observed in “MH vs. M” or “MC vs. M”, respectively. The shared DEGs were most enriched in VFA absorption and metabolism, such as peroxisome proliferator-activated receptor (PPAR) signaling pathway, butanoate metabolism, and synthesis and degradation of ketone bodies. Additionally, a weighted gene co-expression network analysis identified M16 (2,052 genes) and M18 (579 genes) modules were positively correlated with VFA and rumen wall morphology. The M16 module was mainly related to metabolism pathway, while the M18 module was mainly associated with signaling transport. Moreover, hay specifically depressed expression of genes involved in cytokine production, immune response, and immunocyte activation, and concentrate starter mainly altered nutrient transport and metabolism, especially ion transport, amino acid, and fatty acid metabolism.

Conclusions
The energy production during VFA metabolism may drive the rumen wall development directly. The hay introduction facilitated establishment of immune function, while the concentrate starter enhanced nutrient transport and metabolism, which are important biological processes required for rumen development.
Genomics-driven drug discovery based on disease-susceptibility genes
Authors: Sonehara Kyuto , Okada Yukinori 
Published: March 2021

AbstractGenome-wide association studies have identified numerous disease-susceptibility genes. As knowledge of gene–disease associations accumulates, it is becoming increasingly important to translate this knowledge into clinical practice. This challenge involves finding effective drug targets and estimating their potential side effects, which often results in failure of promising clinical trials. Here, we review recent advances and future perspectives in genetics-led drug discovery, with a focus on drug repurposing, Mendelian randomization, and the use of multifaceted omics data.
Political economy analysis of the performance‐based financing programme in Afghanistan
Authors: Salehi Ahmad Shah , Blanchet Karl , Vassall Anna , Borghi Josephine 
Published: March 2021

Abstract
Background
Performance-based financing (PBF) has attracted considerable attention in recent years in low and middle-income countries. Afghanistan’s Ministry of Public Health (MoPH) implemented a PBF programme between 2010 and 2015 to strengthen the utilisation of maternal and child health services in primary health facilities. This study aimed to examine the political economy factors influencing the adoption, design and implementation of the PBF programme in Afghanistan.

Methods
Retrospective qualitative research methods were employed using semi structured interviews as well as a desk review of programme and policy documents. Key informants were selected purposively from the national level (n = 9), from the province level (n = 6) and the facility level (n = 15). Data analysis was inductive as well as deductive and guided by a political economy analysis framework to explore the factors that influenced the adoption and design of the PBF programme. Thematic content analysis was used to analyse the data.

Results
The global policy context, and implementation experience in other LMIC, shaped PBF and its introduction in Afghanistan. The MoPH saw PBF as a promise of additional resources needed to rebuild the country’s health system after a period of conflict. The MoPH support for PBF was also linked to their past positive experience of performance-based contracting. Power dynamics and interactions between PBF programme actors also shaped the policy process. The PBF programme established a centralised management structure which strengthened MoPH and donor ability to manage the programme, but overlooked key stakeholders, such as provincial health offices and non-state providers. However, MoPH had limited input in policy design, resulting in a design which was not well tailored to the national setting.

Conclusions
This study shows that PBF programmes need to be designed and adapted according to the local context, involving all relevant actors in the policy cycle. Future studies should focus on conducting empirical research to not only understand the multiple effects of PBF programmes on the performance of health systems but also the main political economy dynamics that influence the PBF programmes in different stages of the policy process.
Unveiling novel inhibitors of dopamine transporter via in silico drug design, molecular docking, and bioavailability predictions as potential antischizophrenic agents
Authors: Olasupo Sabitu Babatunde , Uzairu Adamu , Shallangwa Gideon Adamu , Uba Sani 
Published: March 2021

Abstract
Background
The inhibition of dopamine transporter is known to play a significant role in the treatment of schizophrenia-related and other mental disorders. In a continuing from our previous study, computational drug design approach, molecular docking simulation, and pharmacokinetics study were explored for the identification of novel inhibitors dopamine transporter as potential Antischizophrenic agents. Consequently, thirteen (13) new inhibitors of dopamine transporter were designed by selecting the molecule with serial number 39 from our previous study as the template molecule because it exhibits good pharmacological attributes.

Results
Molecular docking simulation results revealed excellent molecular interactions between the protein target (PDB: 4m48) and the ligands (designed inhibitors) with major interactions that involved hydrogen bonding and hydrophobic interactions. Also, some of the designed inhibitors displayed a superior binding affinity range from − 10.0 to − 10.7 kcal/mol compared to the referenced drug (Lumateperone) with a binding affinity of − 9.7 kcal/mol. Computed physicochemical parameters showed that none of the designed inhibitors including the referenced drug violate Lipinski’s rule of five indicating that all the designed inhibitors would be orally bioavailable as potential drug candidates. Similarly, the ADMET/pharmacokinetics evaluations of some designed inhibitors revealed that they possessed good absorption, distribution, metabolism and excretion properties and none of the inhibitors is neither carcinogens nor toxic toward human ether-a-go-go related gene (hERG I) inhibitor or skin sensitization. Likewise, the BOILED-Egg graphics unveils that all the designed inhibitors demonstrate a high probability to be absorbed by the human gastrointestinal tract and could permeate into the brain. Besides, the predicted bioactive parameters suggested that all the selected inhibitors would be active as drug candidates. Furthermore, the synthetic accessibility scores for all the selected inhibitors and referenced drug lied within the easy zone (i.e., between 1–4) with their computed values range from 2.55 to 3.92, this implies that all the selected inhibitors would be very easy to synthesize in the laboratory.

Conclusions
Hence, all the designed inhibitors having shown excellent pharmacokinetics properties and good bioavailabilities attributes with remarkable biochemical interactions could be developed and optimized as novel Antischizophrenic agents after the conclusion of other experimental investigations.
Improved estimation of ice and water contents in alpine permafrost through constrained petrophysical joint inversion: The Hoher Sonnblick case study
Authors: Steiner Matthias , Wagner Florian M. , Maierhofer Theresa , Schöner Wolfgang , Flores Orozco Adrián 
Published: March 2021

Quantitative estimation of subsurface water and ice content values is critical for the understanding and modeling of permafrost evolution in alpine regions. Geophysical methods permit the assessment of subsurface conditions in a noninvasive and quasicontinuous manner; in particular, the combination of seismic refraction tomography (SRT) and electrical resistivity tomography (ERT) through a petrophysical model can quantitatively estimate ground water and ice content values. For the Hoher Sonnblick study area (3106 m.a.s.l., Austrian Alps), we have investigated the improved estimation of water and ice content values based on SRT, ERT, and ground-penetrating radar data collected in June and October 2019. We solve for the water and ice content values following different approaches, namely, (1) the independent inversion and subsequent transformation of the imaging results to the target parameters through a petrophysical model and (2) the petrophysical joint inversion (PJI) of the data sets. Supported by a synthetic study, we determine that the incorporation of structural and porosity constraints in the PJI allows for an improved quantitative characterization of subsurface conditions. For our measurements at Hoher Sonnblick, the constrained PJI resolves a shallow debris layer characterized by high air content and porosity, on top of a layer with lower porosity corresponding to fractured gneiss, and the bedrock layer with the lowest porosity. For both time steps, we find high water content at the lower end of the investigated area. Substantial variations in the subsurface ice content resolved between June and October 2019 indicate a correlation between the high water content and the meltwater discharge within the debris layer. Our results demonstrate that the constrained PJI permits an improved characterization of subsurface hydrologic parameters in alpine permafrost environments.
Well-logging evaluation of the shale gas potential in the lower Silurian Longmaxi Formation, Weiyuan, southern Sichuan Basin, China
Authors: Zhou Guangzhao , Hu Zhiming , Liu Xiangui , Duan Xianggang , Chang Jin 
Published: March 2021

Recent observations of shale gas breakthroughs in the Weiyuan marine shale gas play in the Sichuan Basin have attracted great interest. To better understand these breakthroughs, we have used core description, cyro-focused ion beam scanning electron microscopy data, X-ray diffraction data, organic geochemistry, and well-logging data to better understand the reservoir characteristics carbonaceous shale, calcareous shale, and siliceous shale lithology, with a focus on organic-rich shale units. We find that conventional well-log methods are effective in mapping the spatial distribution of organic-rich shale in the Weiyuan area where the total organic carbon (TOC) content in the Longmaxi Formation ranges from 1.35% to 6.95%, averaging 4.42%. The kerogen is type I-II, and the vitrinite reflectance (Ro) is greater than 2.57%, which indicates that the formation is susceptible to shale gas accumulation. The clay mineral content ranges from 48 to 63 wt% (avg. 51 wt%) with illite and chlorite averaging 73.8% and 25.7%, respectively. The brittle mineral quartz and plagioclase content ranges from 32 to 61 wt% (avg. 47 wt%). Compared to the surrounding lithologic units, the marine shale exhibits relatively high gamma ray, neutron, sonic, resistivity, potassium, and uranium (U) values and relatively low density, photoelectric effect, and thorium/U values, allowing us to construct crossplots to define the units of interest. Using the same process, we quantify the TOC content providing a spatial distribution of organic-rich shale using conventional well logging.
Submarine landslide origin of a tsunami at the Black Sea coast: Evidence based on swath bathymetry and 3D seismic reflection data
Authors: Tishchenko Ilya , Tari Gabor , Fallah Mohammad , Floodpage Jonathan 
Published: March 2021

Tsunami waves were observed along the Bulgarian Black Sea coastline on 7 May 2007. The maximum rise and fall of the sea level were 1.2 and 2.0 m, respectively, with wave oscillations between 4 and 8 min. At first, submarine landsliding and then later on atmospheric disturbance were suggested as the cause of the tsunami. Numerical modeling, assuming a landslide displacing 30–60 million m3 material on the slope with a thickness range of more than 20–40 m, could reproduce the main characteristics of the recorded tsunami. In this early model, the landslide initiated on the shelf at a water depth of 100 m with a runout of approximately 20 km into 1000 m water depth. Subsequent and recent numerical modeling suggested that the failure may have initiated on the slope, anywhere between 200 and 1500 m seafloor depth. The runout of the transported sediments in these latest model was at 1850 m water depth. Just a few years after the tsunami, OMV and its joint venture partners, TOTAL and Repsol, acquired modern deepwater data sets in the same area where the submarine landsliding was assumed to occur. These data sets included multibeam swath bathymetry area and 3D reflection seismic data. These data sets offer a possibility to establish the presence of speculative submarine landslide responsible for the tsunami, with its geometry and nature. Our results provide direct evidence for the occurrence of large nonseismic catastrophic sediment failures along the Bulgarian coast. In this study, we illustrate Quaternary submarine landslides on 3D seismic reflection data immediately below the one responsible for the 2007 event; we also briefly point out the potential interpretation pitfall related to sediment waves and mass transport complexes.
Development and Evaluation of a Navigation-Based, Multilevel Intervention to Improve the Delivery of Timely, Guideline-Adherent Adjuvant Therapy for Patients With Head and Neck Cancer
Authors: Graboyes Evan M. , Sterba Katherine R. , Li Hong , Warren Graham W. , Alberg Anthony J. , Calhoun Elizabeth A. , Nussenbaum Brian , McCay Jessica , Marsh Courtney H. , Osazuwa-Peters Nosayaba , Neskey David M. , Kaczmar John M. , Sharma Anand K. , Harper Jennifer , Day Terry A. , Hughes-Halbert Chanita 
Published: March 2021

PURPOSE:More than half of patients with head and neck squamous cell carcinoma (HNSCC) experience a delay initiating guideline-adherent postoperative radiation therapy (PORT), contributing to excess mortality and racial disparities in survival. However, interventions to improve the delivery of timely, equitable PORT among patients with HNSCC are lacking. This study (1) describes the development of NDURE (Navigation for Disparities and Untimely Radiation thErapy), a navigation-based multilevel intervention (MLI) to improve guideline-adherent PORT and (2) evaluates its feasibility, acceptability, and preliminary efficacy.METHODS:NDURE was developed using the six steps of intervention mapping (IM). Subsequently, NDURE was evaluated by enrolling consecutive patients with locally advanced HNSCC undergoing surgery and PORT (n = 15) into a single-arm clinical trial with a mixed-methods approach to process evaluation.RESULTS:NDURE is a navigation-based MLI targeting barriers to timely, guideline-adherent PORT at the patient, healthcare team, and organizational levels. NDURE is delivered via three in-person navigation sessions anchored to case identification and surgical care transitions. Intervention components include the following: (1) patient education, (2) travel support, (3) a standardized process for initiating the discussion of expectations for PORT, (4) PORT care plans, (5) referral tracking and follow-up, and (6) organizational restructuring. NDURE was feasible, as judged by accrual (88% of eligible patients [100% Blacks] enrolled) and dropout (n = 0). One hundred percent of patients reported moderate or strong agreement that NDURE helped solve challenges starting PORT; 86% were highly likely to recommend NDURE. The rate of timely, guideline-adherent PORT was 86% overall and 100% for Black patients.CONCLUSION:NDURE is a navigation-based MLI that is feasible, is acceptable, and has the potential to improve the timely, equitable, guideline-adherent PORT.
Hidden energy flows in strongly coupled nonequilibrium systems
Authors: Large Steven J. , Sivak David A. 
Published: March 2021

Abstract
Quantifying the flow of energy within and through fluctuating nanoscale systems poses a significant challenge to understanding microscopic biological machines. A common approach involves coarse graining, which allows a simplified description of such systems. This has the side effect of inducing so-called hidden contributions (due to sub-resolution dynamics) that complicate the resulting thermodynamics. Here we develop a thermodynamically consistent theory describing the nonequilibrium excess power internal to autonomous systems, and introduce a phenomenological framework to quantify the hidden excess power associated with their operation. We confirm our theoretical predictions in numerical simulations of a minimal model for both a molecular transport motor and a rotary motor.