bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multimodal dataset of real-time 2D and static 3D MRI of healthy French speakers
Authors: Isaieva Karyna , Laprie Yves , Leclère Justine , Douros Ioannis K. , Felblinger Jacques , Vuissoz Pierre-André 
Published: October 2021

AbstractThe study of articulatory gestures has a wide spectrum of applications, notably in speech production and recognition. Sets of phonemes, as well as their articulation, are language-specific; however, existing MRI databases mostly include English speakers. In our present work, we introduce a dataset acquired with MRI from 10 healthy native French speakers. A corpus consisting of synthetic sentences was used to ensure a good coverage of the French phonetic context. A real-time MRI technology with temporal resolution of 20 ms was used to acquire vocal tract images of the participants speaking. The sound was recorded simultaneously with MRI, denoised and temporally aligned with the images. The speech was transcribed to obtain phoneme-wise segmentation of sound. We also acquired static 3D MR images for a wide list of French phonemes. In addition, we include annotations of spontaneous swallowing.
Aphids harbouring different endosymbionts exhibit differences in cuticular hydrocarbon profiles that can be recognized by ant mutualists
Authors: Hertaeg Corinne , Risse Marion , Vorburger Christoph , De Moraes Consuelo M. , Mescher Mark C. 
Published: October 2021

AbstractCuticular hydrocarbons (CHCs) have important communicative functions for ants, which use CHC profiles to recognize mutualistic aphid partners. Aphid endosymbionts can influence the quality of their hosts as ant mutualists, via effects on honeydew composition, and might also affect CHC profiles, suggesting that ants could potentially use CHC cues to discriminate among aphid lines harbouring different endosymbionts. We explored how several strains of Hamiltonella defensa and Regiella insecticola influence the CHC profiles of host aphids (Aphis fabae) and the ability of aphid-tending ants (Lasius niger) to distinguish the profiles of aphids hosting different endosymbionts. We found significant compositional differences between the CHCs of aphids with different infections. Some endosymbionts changed the proportions of odd-chain linear alkanes, while others changed primarily methyl-branched compounds, which may be particularly important for communication. Behavioural assays, in which we trained ants to associate CHC profiles of endosymbiont infected or uninfected aphids with food rewards, revealed that ants readily learned to distinguish differences in aphid CHC profiles associated with variation in endosymbiont strains. While previous work has documented endosymbiont effects on aphid interactions with antagonists, the current findings support the hypothesis that endosymbionts also alter traits that influence communicative interactions with ant mutualists.
Development of an aerogenous Escherichia coli infection model in adult broiler breeders
Authors: Kromann Sofie , Olsen Rikke Heidemann , Bojesen Anders Miki , Jensen Henrik Elvang , Thøfner Ida 
Published: October 2021

AbstractEscherichia coli constitutes an immense challenge to the poultry industry due to its devastating effect on productivity, mortality, and carcass condemnations. To aid future studies on disease mechanisms and interventions, an aerogenous infection model was established in adult broiler breeders. Hens (n = 120) were randomly allocated into six groups receiving either aerosolised E. coli or vehicle, or intratracheal E. coli or vehicle. Replication of aerosol inoculation was performed on distinct days. Alternating euthanasia time points were predetermined in order to evaluate the progression of the disease. All animals were thoroughly necropsied, and bacteriological samples were collected as well as tissues for histopathology. Birds inoculated with E. coli exhibited clinical signs and developed characteristic gross and histopathological lesions of colibacillosis, including splenic fibrinoid necrosis, folliculitis, polyserositis and impaction of parabronchi with fibrinoheterophilic exudate and necrotic debris, as well as positive in situ localisation of intralesional E. coli by immunohistochemistry. This study presents a successful development of a discriminative colibacillosis model through aerosol inoculation of adult broiler breeders. Gross and histopathological lesions characteristic of colibacillosis were established in two independent experiments.
Computational modeling of thermal combination therapies by magneto-ultrasonic heating to enhance drug delivery to solid tumors
Authors: Souri Mohammad , Soltani Madjid , Moradi Kashkooli Farshad 
Published: October 2021

AbstractFor the first time, inspired by magnetic resonance imaging-guidance high intensity focused ultrasound (MR-HIFU) technology, i.e., medication therapy and thermal ablation in one session, in a preclinical setting based on a developed mathematical model, the performance of doxorubicin (Dox) and its encapsulation have been investigated in this study. Five different treatment methods, that combine medication therapy with mild hyperthermia by MRI contrast ($$\gamma -{Fe}_{2}{O}_{3}$$

γ
-

Fe

2

O
3

) and thermal ablation via HIFU, are investigated in detail. A comparison between classical chemotherapy and thermochemistry shows that temperature can improve the therapeutic outcome by stimulating biological properties. On the other hand, the intravascular release of ThermoDox increases the concentration of free drug by 2.6 times compared to classical chemotherapy. The transport of drug in interstitium relies mainly on the diffusion mechanism to be able to penetrate deeper and reach the cancer cells in the inner regions of the tumor. Due to the low drug penetration into the tumor center, thermal ablation has been used for necrosis of the central areas before thermochemotherapy and ThermoDox therapy. Perfusion of the region around the necrotic zone is found to be damaged, while cells in the region are alive and not affected by medication therapy; so, there is a risk of tumor recurrence. Therefore, it is recommended that ablation be performed after the medication therapy. Our model describes a comprehensive assessment of MR-HIFU technology, taking into account many effective details, which can be a reliable guide towards the optimal use of drug delivery systems.
Warming events projected to become more frequent and last longer across Antarctica
Authors: Feron Sarah , Cordero Raúl R. , Damiani Alessandro , Malhotra Avni , Seckmeyer Gunther , Llanillo Pedro 
Published: October 2021

AbstractSummer temperatures are often above freezing along the Antarctic coastline, which makes ice shelves and coastal snowpacks vulnerable to warming events (understood as periods of consecutive days with warmer than usual conditions). Here, we project changes in the frequency, duration and amplitude of summertime warming events expected until end of century according to two emission scenarios. By using both global and regional climate models, we found that these events are expected to be more frequent and last longer, continent-wide. By end of century, the number of warming events is projected to double in most of West Antarctica and to triple in the vast interior of East Antarctica, even under a moderate-emission scenario. We also found that the expected rise of warming events in coastal areas surrounding the continent will likely lead to enhanced surface melt, which may pose a risk for the future stability of several Antarctic ice shelves.
Strontium and oxygen isotopes to trace mobility routes during the Bell Beaker period in the north of Spain
Authors: Ortega L. A. , Alonso-Fernández C. , Guede I. , Zuluaga M. C. , Alonso-Olazabal A. , Jiménez-Echevarría J. 
Published: October 2021

AbstractStrontium and oxygen isotopes of individuals from El Hundido and Valdescusa (north of Spain) sites, corresponding to the Bell Beaker culture, were analysed in order to determine mobility patterns and provenance areas. Strontium and oxygen isotope ratios in three teeth from two individuals at El Hundido and two teeth from the five individuals at Valdescusa were studied. The analyses were performed in both dentine and enamel fractions. 87Sr/86Sr ratios of El Hundido individuals indicate one was of foreign origin and the other was local whereas at Valdescusa were all of foreign provenance. Calculated δ18Ow values of El Hundido suggest a provenance from the geographical area close to the site while the Valdescusa would come from a warmer region. The comparison of oxygen and strontium isotope signatures indicate the west of the Iberian Peninsula (Zamora or the east of Leon regions) as the provenance area for the foreign individual at El Hundido and southwest France (Garonne basin) as the region of provenance for the Valdescusa.
Crossing design shapes patterns of genetic variation in synthetic recombinant populations of Saccharomyces cerevisiae
Authors: Phillips Mark A. , Kutch Ian C. , McHugh Kaitlin M. , Taggard Savannah K. , Burke Molly K. 
Published: October 2021

Abstract“Synthetic recombinant” populations have emerged as a useful tool for dissecting the genetics of complex traits. They can be used to derive inbred lines for fine QTL mapping, or the populations themselves can be sampled for experimental evolution. In the latter application, investigators generally value maximizing genetic variation in constructed populations. This is because in evolution experiments initiated from such populations, adaptation is primarily fueled by standing genetic variation. Despite this reality, little has been done to systematically evaluate how different methods of constructing synthetic populations shape initial patterns of variation. Here we seek to address this issue by comparing outcomes in synthetic recombinant Saccharomyces cerevisiae populations created using one of two strategies: pairwise crossing of isogenic strains or simple mixing of strains in equal proportion. We also explore the impact of the varying the number of parental strains. We find that more genetic variation is initially present and maintained when population construction includes a round of pairwise crossing. As perhaps expected, we also observe that increasing the number of parental strains typically increases genetic diversity. In summary, we suggest that when constructing populations for use in evolution experiments, simply mixing founder strains in equal proportion may limit the adaptive potential.
Increased decision latency in alcohol use disorder reflects altered resting-state synchrony in the anterior salience network
Authors: Canessa Nicola , Basso Gianpaolo , Carne Irene , Poggi Paolo , Gianelli Claudia 
Published: October 2021

AbstractIncreased decision latency in alcohol use disorder (AUD) has been generally explained in terms of psychomotor slowing. Recent results suggest that AUD patients’ slowed decision-making might rather reflect alterations in the neural circuitry underlying the engagement of controlled processing by salient stimuli. We addressed this hypothesis by testing a relationship between decision latency at the Cambridge Gambling Task (CGT) and intrinsic brain activity in 22 individuals with AUD and 19 matched controls. CGT deliberation time was related to two complementary facets of resting-state fMRI activity, i.e. coherence and intensity, representing early biomarkers of functional changes in the intrinsic brain architecture. For both metrics, we assessed a multiple regression (to test a relationship with deliberation time in the whole sample), and an interaction analysis (to test a significantly different relationship with decision latency across groups). AUD patients’ slowed deliberation time (p < 0.025) reflected distinct facets of altered intrinsic activity in the cingulate node of the anterior salience network previously associated with the “output” motor stage of response selection. Its heightened activity in AUD patients compared with controls, tracking choice latency (p < 0.025 corrected), might represent a compensation mechanism counterbalancing the concurrent decrease of its internal coherent activity (p < 0.025 corrected). These findings provide novel insights into the intrinsic neural mechanisms underlying increased decision latency in AUD, involving decreased temporal synchronicity in networks promoting executive control by behaviourally relevant stimuli. These results pave the way to further studies assessing more subtle facets of decision-making in AUD, and their possible changes with rehabilitative treatment.
Assessment of minimal active space CASSCF-SO methods for calculation of atomic Slater–Condon and spin–orbit coupling parameters in d- and f-block ions
Authors: Walisinghe Alvin J. , Chilton Nicholas F. 
Published: October 2021

CASSCF-SO calculations in OpenMolcas are used to determine Slater-Condon and SOC parameters for 3dn, 4dn, 5dn and 4fn ions. We quantify the error of minimal active space approaches and compare to other similar methods.
Fast spatial orthogonal frequency‐division multiplexing based on two‐dimensional discrete cosine transform for a pixelated optical wireless communication system
Authors: Xu Zi‐Xin , Bi Longtao , Chen Qingqing 
Published: September 2021

AbstractPixelated two‐dimensional (2‐D) optical wireless communication systems, with intensity‐modulation and direct‐detection (IM/DD), are capable to transmit data at high data rates by modulating the data into image intensities at the transmitter. Frequency division modulation (FDM) and space‐domain modulation (SDM) are two common modulation schemes in a 2‐D pixelated system. Generally, FDM is preferred because FDM benefits from the capability of controlling the spectrum of transmitting signals so that the output signal could be shaped according to the characteristics of a particular optical channel. However, the computational complexity of FDM is relatively high and complex computation is needed at both the transmitter and the receiver. In this work, a fast orthogonal frequency‐division multiplexing (FOFDM) modulation which employs 2‐D inverse discrete cosine transform (IDCT2) instead of 2‐D inverse Fourier transform (IFFT2) is presented. As the image intensities must be real and positive, two schemes are hereby introduced to generate unipolar image intensities. The proposed FOFDM is simulated and discussed in terms of key characterisations including the signal spectrum, spectral efficiency, peak to average power ratio (PAPR), bit error ratio (BER) and computational complexity. Compared with traditional spatial orthogonal frequency‐division multiplexing (OFDM) based on IFFT2, the proposed FOFDM has similar BER performance, twice the spatial efficiency for the same constellation size, lower computational complexity and a much simpler structure in the transmitter.
Target detection based on time reversal with polarisation array antennas
Authors: Zhang Zhaoming , Chen Baixiao , Yang Minglei , Liu Meng 
Published: September 2021

AbstractPolarisation diversity radar enhances the performance of target detection. Time reversal exploits the multipath effect by adaptively matching propagation channels to improve the signal‐to‐noise ratio (SNR) and realise high detectability. This work combines polarisation diversity and time‐reversal technology to propose a time‐reversal detector suitable for a polarisation array radar. The maximum likelihood estimate is carried out for the time‐varying channel response to solve the channel mismatch problem, which may cause the degradation of time‐reversal performance. In addition, a conventional polarisation detector is developed under the same varying channel scenario to benchmark the time‐reversal detector, and furthermore, the SNR gain of the time‐reversal detector over the conventional detector is derived. Numerical simulations demonstrate the superiority of the time‐reversal detector. Both the polarisation detectors proposed can take advantage of the channel variations to improve the detectability, and the greater the energy brought by the channel changes, the better the detection performance achieved.
Ethnoveterinary Uses of Certain Yemeni Plants: A Review of the Scientific Evidence
Authors: Alasbahi Rawiya H. , Groot Maria J. 
Published: October 2021

AbstractLivestock is an important and integral component of agriculture production in Yemen and contributes 28% of the total agricultural production income. Research in the field of Yemeni ethnoveterinary medicine is limited to a few studies. Therefore, our work aims to substantiate scientifically the ethnoveterinary use of some documented plant species based on a literature review of their bioactivities and toxicological properties. Searching the scientific literature has revealed various pharmacological activities that may support the claimed healing activities of 11 out of 14 plant species for some of their ethnoveterinary utilization. This comprises the use of Aloe spp. latex for constipation, worms, boils, and wounds; Boswellia sacra underbark for wounds and its oleo-gum resin for mastitis; Soqotraen Boswellia species as an insect repellent; Cissus rotundifolia for stomach pain; Cyphostemma digitatum as an appetite stimulant; Psiadia
punctulate for bone fracture; Pulicaria undulata as an insect repellent; combinations of Aristolochia bracteolate with Sorghum bicolor grains for bloating; Rumex nervosus and salt for eye pimples; and Trigonella foenum-graecum seeds with Hordeum vulgare grains for constipation. Some plants were found to demonstrate various toxic effects in in vivo and in vitro experimental studies. The local administration of Calotropis procera latex was also reported to induce an intense inflammatory response. It can be concluded that our work has provided valuable scientific information on the biological and toxic activities of some Yemeni ethnoveterinary remedies that could be utilized for the benefit of farmers to ration the use of these remedies and avoiding their toxicity.
Naturally Derived Photoinitiators for Dental and Biomaterials Applications
Authors: Abdul-Monem Mohamed Mahmoud 
Published: October 2021

AbstractBiocompatibility of materials used in dental and biomaterials applications is very important and depends on the components of these materials. Photopolymerized materials for dental and biomaterials applications have been progressively used since the 1970s. One of the crucial components in these materials is the photoinitiator (PI) that initiates the polymerization reaction. Synthetic PIs are the most commonly used types, but owing to their drawbacks such as cytotoxicity, insolubility in water, and high cost, research on naturally derived (bio-sourced) PIs is growing, to find an alternative to these synthetic types, especially in the growing field of three-dimensional (3D) printing and bioprinting of biomaterials for tissue engineering applications. Naturally derived PIs are biocompatible, highly water-soluble, and abundant. Naturally derived PIs have been used to prepare experimental dentine bonding agents, dentine primers, photo-crosslinked hydrogels for tissue engineering applications, antibacterial coatings, guided tissue regeneration membranes, and 3D printed biomaterials. An electronic search was done using MEDLINE/PubMed and Scopus databases using the keywords naturally derived, bio-sourced, PIs, dental, biomaterials, 3D printing, and 3D bioprinting, to review potential naturally derived PIs for dental and biomaterials applications. There are a variety of naturally derived PIs with various colors and absorption spectra to choose from, according to the intended application. Most of naturally derived PIs can be used with modern conventional dental light curing units, making them applicable for experimental studies for potential dental and biomaterials applications. Due to their biocompatibility and availability it is expected that in the upcoming years, research on naturally derived PIs and their dental and biomaterials applications will increase especially in the growing field of 3D bioprinting in which cell viability is essential; thus this review was done.
Do Orthodontists and Orthodontic Residents Perceive that Work-Life Balance and Work-Family Conflicts Affect Their Organizational Commitment?
Authors: Yemitan Tolulase Abosede , Adeyemi Tope Emmanuel 
Published: October 2021

AbstractObjectives Two of lives’ most important domains may be in conflict with each other. This study investigated the association between perceived work-life balance (WLB), work interference with family (WIF), family interference with work (FIW), and organizational commitment (OC) of Nigerian orthodontists and orthodontic residents.Materials and Methods Consultant orthodontists (n = 37) as well as orthodontics residents (n = 33) responded to an electronic questionnaire.Statistical Analysis Multivariate analysis of variance assessed significant differences among demographic and career features on WLB, WIF, and FIW. Spearman’s correlation coefficient and then multiple regression analysis examined relationships among perception of WLB, WIF, FIW, and OC.Results Perceived WLB and WIF had statistically significant negative correlation with OC among Nigerian orthodontic practitioners. However, the study finds a positive, but not statistically significant correlation of perception of FIW and OC.Conclusion Perceived WLB and WIF are significant contributors to levels of OC among Nigerian orthodontists and orthodontic residents. Multiple regression analysis identified a model that includes perceived WLB, WIF, and FIW that accounts for 16.7% of the variation in OC.
Severe Spontaneous Pneumomediastinum in a Girl with Cystic Fibrosis
Authors: Zsiborás Csaba , Adonyi Mária , Stankovics József , Farkas András , Vajda Peter , Rózsai Barnabás 
Published: October 2021

AbstractWe report on an 11-year-old girl with cystic fibrosis who presented with thoracic pain and an extensive subcutaneous emphysema and subsequently developed progressive respiratory distress. The chest computed tomography revealed a huge pneumomediastinum. Due to the development of severe respiratory failure, urgent needle thoracocentesis was necessary that resulted in only temporary improvement. Therefore, under general anesthesia two mediastinal drains were introduced. Using active suction, the size of the pneumomediastinum decreased gradually and the drains were removed after 3 weeks. Here, we describe an extremely rare situation, when acute surgical intervention was necessary in a child with spontaneous pneumomediastinum.