bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Bivalent CEACAM6/4-1BBL Genetic Vaccine Combined with Anti-PD1 Antibody in HCT116 Xenograft Mice
Authors: Li Yuzhen , Zhu Xiaodan , You Jianliang , Zhang Baonan , Huang Xiaona , Jin Chunhui 
Published: August 2021

Abstract
Background:Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. Anti-PD1/PD-L1 drugs are feasible treatment for CRC, and genetic vaccine is a promising immunotherapy for cancers. However, anti-tumor efficacy of genetic vaccines including CEACAM6/4-1BBL genes combined with immunocheckpoint inhibitors on CRC has not been reported. We used human colon cancer cell line (HCT116) to establish a xenograft mouse model, and applied [89Zr]-labeled PD-L1 antibody ([89Zr]KN035) for PET imaging. Methods:Attenuated Salmonella typhimurium 3261 was transformed by eukaryotic expression plasmid containing CEACAM6/4-1BBL genes as an anti-tumor vaccine, and the combined anti-tumor immunotherapy with bivalent genetic vaccine and anti-PD1 antibody was conducted. MicroPET was performed to non-invasively and dynamically observe the changes of tumor tissues and expression of PD-L1. Results:We found that the recombinant double-gene plasmids were stably expressed in COS7 cells. The findings showed PD-L1 expression in HCT116 tumor model, and thus anti-PD1/PD-L1 drug was suitable for the treatment and [89Zr]KN035 could be used in whole-body PET imaging for in vivo observation of the model. Efficacy observation results of tumor growth, PET scanning and immunohistochemical assays showed that the combined therapy had obvious improvement in effectiveness over vaccine alone.Conclusions:This study supports that combination of genetic vaccines and anti-immunocheckpoint immunotherapy can inhibit HCT116 tumor growth and provide better efficacy via overcoming the immune tolerance and suppressive microenvironment and inhibiting the immune brake induced by immunocheckpoint activation.
Lake Surface Area Forecasting Using Integrated Satellite-SARIMA-Long-Short-Term Memory Model
Authors: Soltani Keyvan , Azari Arash , Zeynoddin Mohammad , Amiri Afshin , Ebtehaj Isa , Ouarda Taha B.M.J. , Gharabaghi Bahram , Bonakdari Hossein 
Published: August 2021

Abstract
Lake Water Surface Area (WSA) plays a vital role in environmental preservation and future water resource planning and management. Accurately mapping, monitoring and forecasting Lake WSA changes are of great importance to regulatory agencies. This study used the MODIS satellite images to extract a monthly time series of WSA of two lakes located in Iran from 2001 to 2019. Following a consequence of image and time series preprocessing to obtain the preprocessed lake surface area time series, the outcomes were modeled by the Long-Short-Term Memory (LSTM) deep learning (DL) method, the stochastic Seasonal Auto-Regressive Integrated Moving Average (SARIMA) method and hybridization of these two techniques with the objective of developing WSA forecasts. After separate standardization and normalization of AL TS and reevaluation of the preprocessed data, the SARIMA (1, 0, 0) (0, 1, 1)12 model outperformed sole LSTM models with correlation index of (R) 0.819, mean absolute error (MAE) of 49.425 and mean absolute percentage error (MAPE) of 0.106. On the other hand, the hybridization (stochastic-DL) enhanced the reproduction of the primal statistical properties of WSA data and caused better mediation. However, the other accuracy indices did not change markedly (R 0.819, MAE 49.310, MAPE 0.105). The multi-step preprocessing and reevaluation also caused all LSTM models to produce their best results by less than 12 inputs.
Discriminative Aging Subspace Learning for Age Estimation
Authors: Sawant Manisha , Bhurchandi Kishor 
Published: August 2021

Abstract
Hidden factor analysis ( HFA ) has been widely used in age invariant face recognition systems. It decomposes facial features into independent age factor and identity factor. Age invariant face recognition systems utilize identity factor for face recognition; however, the age factor remains unutilized . The age component of the hidden factor analysis model depends on the subject's age, hence it carries a significant age related information. In this paper, we propose the HFA model based discriminative manifold learning method for age estimation. Further, multiple regression methods are applied on low dimensional features learned from the aging subspace. Extensive experiments are performed on a large scale aging database MORPH II and the accuracy of our method is found superior to the current state-of-the-art methods.
Thematic Dynamics of Internet of Things (IoT): Impact on Digital Personalized Healthcare (PHC)
Authors: Lainjo Bongs 
Published: August 2021

Abstract
Background: Information technology has continued to shape contemporary thematic trends. Advances in communication have impacted almost all themes ranging from education, engineering, healthcare, and many other aspects of our daily lives. Method: This paper attempts to review the different dynamics of the thematic IoT platforms. A select number of themes are extensively analyzed with emphasis on data mining (DM), personalized healthcare (PHC), and thematic trends of a select number of subjectively identified IoT-related publications over three years. In this paper, the number of IoT-related-publications is used as a proxy representing the number of apps. DM remains the trailblazer, serving as a theme with crosscutting qualities that drive artificial intelligence (AI), machine learning (ML), and data transformation. A case study in PHC illustrates the importance, complexity, productivity optimization, and nuances contributing to a successful IoT platform. Among the initial 99 IoT themes, 18 are extensively analyzed using the number of IoT publications to demonstrate a combination of different thematic dynamics, including subtleties that influence escalating IoT publication themes. Results: Based on findings amongst the 99 themes, the annual median IoT-related publications for all the themes over the four years were increasingly 5510, 8930, 11700, and 14800 for 2016, 2017, 2018, and 2019 respectively; indicating an upbeat prognosis of IoT dynamics. Conclusion: The vulnerabilities that come with the successful implementation of IoT systems are highlighted including the successes currently achieved by institutions promoting the benefits of IoT-related systems like the case study. Security continues to be an issue of significant importance.
Khali pete thaka to teni xadharan*: Lived Experience of Food among Women in Assam
Authors: Bhagawati Purabi , S.S Sumesh 
Published: August 2021

Abstract
The paper explores the lived experiences of food among women from multiple locations of caste, class, tribe, religion and region within Assam, India. The everyday experience of women from Namasudra, Bodo and Char based Muslim communities in Nalbari district forms the empirical context. The various ways of production, procurement, preparation, distribution and consumption of food in these communities are explored. All these practices in general reflect the embodied patriarchal values. The women’s body and nutrition become important for the community when she is pregnant. Here the women have minimal negotiating power, but there has been some resistance of late. Thus, it is argued that the dynamics of conforming and resistance to the dominant practices has to be located in the intersectional matrix of social reality.
The Baseline Serum Uric Acid as an Indicator of Chemotherapy-related Adverse Reaction and Mortality in Aged Males with Stage IIIB or IV Non-small Cell Lung Cancer
Authors: Chen Xiaoyan , Hou Lisha , Li Jianqun , Shen Yanjiao , Dong Birong , Hao Qiukui 
Published: August 2021

Abstract
Objective: To evaluate the accuracy of baseline serum uric acid (BSUA) in estimating adverse effects (AE) and all-cause mortality (ACM) in older males with stage IIIB or IV non-small cell lung cancer (NSCLC) diagnosis.Methods: All patients data was obtained based on medical reports and mortality information was gathered via telephone interviews. BUSA was assessed prior to chemotherapy. Additionally, the end points of this study included chemotherapy-mediated AE and ACM. Binary logistic regression analysis was used to explore the correlation between BSUA and AE. Lastly, Cox regression analysis was utilized to examine the impact of BSUA on ACM.Results: 317 male patients with NSCLC were eligible for this study. Within this population, 18.3% had stage IIIB and 81.7% had stage IV NSCLC. Moreover, 81.39% suffered from adenocarcinoma lung cancer (ACLC), whereas 18.61% suffered from squamous cell carcinoma lung cancer (SCCLC). As of March 1, 2019, 257 (81.07%) patients expired. Following the initial chemotherapeutic course, short-term AE like bone marrow suppression, all infection, liver dysfunction, and digestive reactions, were observed in 13.25%, 7.26%, 5.36%, and 4.1% of cases, respectively. Upon normalizing with confounding factors, the adjusted logistic regression model demonstrated that the moderate BSUA was independently linked to a lower risk of bone marrow suppression (OR=0.407,95% CI:0.178-0.931; p=0.033). Moreover, based on the Cox regression analysis, moderate BSUA was also independently correlated with a low mortality risk (HR=0.705, 95% CI:0.518-0.959; p=0.026).Conclusion：In males patients with stage IIIB or IV NSCLC, BSUA is intimately linked to chemotherapy-driven AE and ACM.
The Dynamics of Neutralizing Antibody Level in One Year After SARS-CoV-2 Infection
Authors: Liang Dan , Zhang Guanting , Huang Mingxing , Hong Wenshan , Li An'an , Liang Yufeng , Wang Tao , Lu Jiahui , Ou Mengdang , Ren Zhongqiang , Lu Huiyi , Zheng Rutian , Cai Xionghui , Pan Xingfei , Xia Jinyu , Ke Changwen 
Published: August 2021

Abstract
Background: A lot of recent researches have focused on the duration of the nature immunity elicited by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. An improved understanding of the immunity offered by the antibodies developed against SARS-CoV-2 in recovered patients is critical for the development of diagnostic tests and vaccines. Methods: We enrolled 114 donors, which providing blood samples after discharge for half a year and one year. Neutralizing antibodies (NAbs) were tested using a micro-neutralization assay. Results: In two tests, 82 of 114 recovered patients completed the first test half a year after discharge and NAbs remained detectable in the vast majority of patients (75/82, 91.46%). In the comparison of the two intervals, 50% (27/54) of individuals had increased NAbs titers. when 31.48% (17/54) of patients remained unchanged. Conclusion: Our results suggest that immune ability is acquired in most individuals infected with SARS-CoV-2 and is sustained in a majority of patients for up to a year after recovery.
Mad, Sad, or Sleepy? Relationships between Postpartum Maternal Anger, Depression, and Sleep: A Cross-Sectional Survey Study
Authors: Ou Christine H. , Hall Wendy A. , Rodney Paddy , Stremler Robyn 
Published: August 2021

Abstract
Background: Although some women experience anger as a mood problem after childbirth, postpartum anger has been neglected by researchers. Poor maternal and infant sleep quality during the postpartum period has been associated with depressive symptoms; however, links between sleep quality and postpartum anger are unclear. This study aimed to determine the proportions of women with significant anger, depressive symptoms, and comorbid anger and depressive symptoms, and to examine maternal and infant sleep quality as correlates of postpartum anger. Methods: This cross-sectional survey study was advertised as an examination of mothers’ and babies’ sleep. Women, with healthy infants between 6 and 12 months of age, were recruited using social media. The survey contained validated measures of maternal and infant sleep quality, and maternal fatigue, social support, anger, depressive symptoms, and cognitions about infant sleep. Results: 278 women participated in the study. Thirty-one percent of women (n = 85) reported high anger levels (≥ 90th percentile on State Anger Scale) while 26% (n = 73) of mothers indicated probable depression (>12 on Edinburgh Postnatal Depression Scale). Women reported a mean of 6.2 hours of sleep (SD = 1.2 hours, range = 4 – 9 hours); over half of the participants rated their sleep as poor (n = 144, 51.8 %). Using robust regression analysis, income (b = -0.74, p < 0.05), parity (b = 2.05, p < 0.01), depressive symptoms (b = 0.59, p < 0.01), maternal sleep quality (b = 0.98, p < 0.05), and maternal anger about infant sleep (b = 0.50, p < 0.01) were significant predictors of maternal anger. Conclusions: Maternal sleep quality and anger about infant sleep are associated with maternal state anger. Clinicians should educate families about sleep pattern changes during the perinatal time frame and assess women’s mood and perceptions of maternal and infant sleep quality in the first postpartum year. They can also offer evidence-based strategies for improving parent-infant sleep. Such health promotion initiatives could reduce maternal anger and support healthy maternal-infant sleep.
North American Fire Weather Catalyzed by the Extratropical Transition of Tropical Cyclones
Authors: Allen Jacob John Stuivenvolt , Wang S.-Y. Simon 
Published: August 2021

Abstract
When tropical cyclones in the western North Pacific turn into midlatitude cyclones, it often perturbs the jet stream, resulting in amplified flow conditions in the north Pacific and various weather extremes in North America. Thus far, however, the complex impacts of extratropical transitioning cyclones (ETCs) on North American fire weather are undocumented. In this study, we group ETCs by the characteristics that are important for their interaction with the jet stream and document the response in North American fire weather, finding that ETCs are consistently associated with enhanced fire weather in North America through amplified pressure gradients and anomalous winds. While the chaotic nature of the ETC and jet stream interaction means that ETCs grouped by similar characteristics and locations can result in varying downstream responses, the composite analysis reveals some areas of consistently enhanced fire weather, including the Pacific Northwest and northern Intermountain West. At a time in which the risk and extent of wildfires in the Western United States is an issue of growing concern, this study represents the first holistic understanding of how ETCs’ downstream perturbations impact fire weather.
Community Analysis of Nematodes Associated with Banana, Identification of root knot nematode and Evaluation the Susceptibility of Some Cultivars to Infection
Authors: Mostafa Radwa G. , El-Zawahry Aida M. , Khalil Ashraf E. M. , Elfarash Ameer E. , Allam Ali D. A. 
Published: August 2021

Abstract
Background Plant-parasitic nematodes are extremely dangerous pests in a variety of economically important crops. The purpose of this study was a survey of all nematode species existing in banana from three sites in Assiut Governorate, Egypt and to characterize the most common species by morphological, morphometric and molecular techniques (PCR with species-specific primers). Then, study of resistance or sensitivity of some banana cultivars to root-knot nematodes.Methods and Results Four nematodes, Meloidogyne, Rotylenchulus reniformis, Helicotylenchus and Pratylenchus were isolated and identified from soil and root samples collected from banana plants. Most frequently occurring of plant parasitic nematode species in banana was Meloidogyne. Former research found differences in species and in resistance to root-knot nematodes among the examined plant cultivars. Identification of Root-knot nematodes by Characterize of morphometric, molecularly, morphological isolate of Meloidogyne related to banana plants. The results revealed that the identified nematode species, Meloidogyne javanica, is the most common plant-parasitic nematodes in all locations. Data on the susceptibility of the tested banana cultivars to M. javanica revealed that Grand Naine was highly susceptible (HS) however, Magraby was susceptible (S) but Williams and Hindi cultivars were moderately resistant (MR).Conclusions we concluded that a survey revealed the significant prevalence of Meloidogyne javanica, the most important nematodes on banana in Assiut. The morphometric, morphological, and molecular identification were harmonic with one another. In addition to the host response of certain banana cultivars, to M. javanica that resistance is of significance and can be helpful to incorporate through planning control measures for root- knot nematodes.
The Effectiveness and Safety of Metronomic Chemotherapy in Patients with Head and Neck Carcinoma: A Systematic Review and Meta-analysis
Authors: Li Xingli , Wang Jianjian , Zhang Ting , Wang Jiabin , Zheng Zhangcai , Wang Cheng , Yang Lan 
Published: August 2021

Abstract
Background: Head and neck carcinoma, usually begins in the squamous cells, not only seriously endangers the quality of life, but brings a heavy financial burden for families and countries. Metronomic chemotherapy, a frequent administration of chemotherapeutic agents at a non-toxic dose, gives an alternative low-cost and tolerated approach for patients. We conducted a systematic review to find the effectiveness and safety of metronomic chemotherapy for head and neck cancer.Methods: We searched seven databases and Clinical.gov from the inception to July 14, 2021. The patients diagnosed head and neck cancer and older than 18 were included. Metronomic chemotherapy was defined as intervention. Randomized and non-randomized trials were all included. Quality assessment of included randomized control trials was performed using the Cochrane Risk-of-Bias criteria, cohort studies using The Newcastle-Ottawa Scale (NOS), single arm trials using the checklist recommended by The Agency for Healthcare Research and Quality (AHRQ). Studies were synthetized using a narrative approach. The indicators used for meta-analysis was hazard ratio (HR).Results: 310 Literatures were potentially eligible from 7 databases, finally 13 records were included. Five studies were of high quality, while eight were of moderate quality. The overall effect of HR for death of five trials reported had no statistically significant (HR=0.89, 95%CI 0.71-1.10). Subgroup analysis by different design showed a statistically significant HR (0.73, 95%CI 0.60-0.90) in randomized control trials while no significant difference in subgroup of prospective study design (HR=1.23, 95%CI 0.72-2.10). As for HR for PFS, there was no significant difference in overall effect of four studies. HR for PFS was 0.84 (95%CI 0.55-1.31). Subgroup analysis of study design showed that randomized control trials produced a significant HR (0.54, 95%CI 0.45-0.64), while prospective studies did not (1.25, 95%CI 0.73, 2.14).Conclusions: Metronomic chemotherapy has been an optimistic option for treatment for advanced head and neck cancer, especially in low income and medical resource-restricted regions.
Leveraging Electronic Medical Record Functionality to Capture Adenoma Detection Rate
Authors: Jones Blake , Scott Frank I. , Espinoza Jeannine , Laborde Sydney , Chambers Micah , Wani Sachin , Edmundowicz Steven , Austin Gregory , Pell Jonathan , Patel Swati G. 
Published: August 2021

Abstract
IntroductionMeasuring the adenoma detection rate (ADR) is critical to providing quality care, however it is also challenging. We aimed to develop a tool using pre-existing electronic health record (EHR) functions to accurately and easily measure total ADR and to provide real-time feedback for endoscopists. MethodsWe utilized the Epic® EHR. With the help of an Epic® analyst, using existing tools, we developed a method by which endoscopy staff could mark whether an adenoma was detected for a given colonoscopy. Using these responses and all colonoscopies performed by the endoscopist recorded in the EHR, ADR was calculated in a report and displayed to endoscopists within the EHR. One endoscopist piloted the tool, and results of the tool were validated against a manual chart review.ResultsOver the pilot period the endoscopist performed 145 colonoscopies, of which 78 had adenomas. The tool correctly identified 76/78 colonoscopies with an adenoma and 67/67 of colonoscopies with no adenomas (97.4% sensitivity, 100% specificity, 98% accuracy). There was no difference in ADR as determined by the tool compared to manual review (53.1% vs. 53.8%, p=0.912).ConclusionsWe successfully developed and pilot tested a tool to measure ADR using existing EHR functionality.
Preparation and Mechanical Property of Alumina Fibers Reinforced Thin Architectural Ceramic Plate
Authors: Zhong Xinzi , Cao Liyun , Huang J.F. , Liu Yijun , Ouyang Haibo , Wang Qinggang 
Published: August 2021

Abstract
The fibers reinforced thin architectural ceramic plate of 900 mm×1800 mm×2.5 mm with high mechanical property was prepared by a fast-sintering method with a controllable fiber dispersion process. The effects of ball-milling time to the dispersity, average length-diameter ratio and microstructure of alumina fibers were investigated respectively. Meanwhile, the alumina fiber contents to the volume density, water absorption, phase transformation and microstructure of the thin ceramic plate were researched. It is found that the two-steps ball-milling process can control the average length-diameter ratio of the alumina fibers effectively and achieve a well dispersion mixture of fibers and ceramic powders, the fast-sintering method is beneficial for the protection of fiber/matrix interface. The trend of the volume density and bending strength increases with the fiber content from 0 wt% to 5 wt% and then decreases with the fiber content from 5 wt% to 15 wt%. The bending strength of this composite reaches the maximum value of 146.8 MPa with the fiber content is 5 wt%, which is corresponding to the strengthening of alumina fibers and the formation of mullite crystallization in fiber/matrix interface and matrix during the fast-sintering process.
Genomic Markers Linked to Meloidogyne Chitwoodi Resistance Introgressed From Solanum Bulbocastanum to Cultivated Potato and Their Utilility in Marker-assisted Selection
Authors: Bali Sapinder , Brown Charles , Mojtahedi Hassan , Yilma Solomon , Ingham Russell E , Cimrhakl Launa , Quick Rich , Sathuvalli Vidyasagar 
Published: August 2021

Abstract
Meloidogyne chitwoodi is a major threat to potato production in the Pacific Northwest region of United States. Infected tubers are rendered unmarketable, hence growers’ profitability is adversely affected. Breeding for nematode resistance is a long-term process and phenotyping the segregating populations for nematode resistance is the most time-consuming and laborious part of the process. Using DNA-based markers closely linked to the nematode resistance trait for marker-assisted selection (MAS) could enhance breeding efficiency and accuracy. In the present study, a pool of phenotyped progenies segregating for nematode resistance and susceptibility were fingerprinted using a 21K single nucleotide polymorphism (SNP) array. Eight candidate SNPs located on potato Chromosome 11, segregating with the nematode resistance trait were identified and used as landmarks for discovery of other marker types such as, simple sequence repeat (SSR) and insertion-deletion (INDEL) markers. Subsequently, a total of eight SNPs, 30 SSRs and four INDELS located on scaffold 11 of Solanum. bulbocastanum were used to design primers; markers were validated on a panel of resistant and susceptible clones. Two SNPs (SB_MC1Chr11-PotVar0066518 and SB_MC1Chr11-PotVar0064140), five SSRs (SB_MC1Chr11-SSR04, SB_MC1Chr11-SSR08, SB_MC1Chr11-SSR10, SB_MC1Chr11-SSR13 and SB_MC1Chr11-SSR20) and one INDEL (SB_MC1Chr11-INDEL4) markers differentated between the resistant and susceptible clones in the test panel as well as other segregating progenies using simple PCR technique and high resolution melting curve analysis. These markers are robust, highly reproducible and easy to use for MAS of nematode resistant potato clones to enhance the breeding program.