bluuebunny/crossref_metadata_2025_split huggingface dataset:
Desquamation Interstitial Pneumonia Presenting as a Solid Mass in the Lung: a Case Report.
Authors: Luo Wen , Wang Wanyu , Shi Yonghong , Lu Fang , Lin Yihua 
Published: October 2021

Abstract
Background: Desquamation interstitial pneumonia (DIP) is a rare type of idiopathic interstitial pneumonia. High resolution computed tomography (HRCT) shows ground glass opacities without the peripheral reticular opacities characteristic of usual interstitial pneumonia (UIP). Here we report a case of DIP presenting as a solid mass in the lung, which is rarely described in the literature.Case presentation: A 77-year-old man presented with dry cough and dyspnea on exertion for one month was admitted to our hospital. The lung CT scan showed there was a pulmonary mass in right lower lung and the patient was scheduled for surgery. He was a sculpture artist, non-smoker and the previous medical history included only mandatory spondylitis without other connective tissue diseases. Nine days post-last CT, the FDG PET/CT demonstrated the mass in the right lower lung was significantly hypermetabolic (SUV value=8.9) but inflammatory exudate could be observed around the mass. We gave antibiotics and performed CT-guided percutaneous lung biopsy. The result showed that there were a large number of macrophages in the alveolar cavity, alveolar epithelial type II cells hyperplasia in some areas and chronic inflammation was noted in the interstitium. Then the desquamative interstitial pneumonia was diagnosed. We gave the patient glucocorticoid therapy, then the patient's symptoms disappeared gradually and the lung CT showed that the pulmonary mass was disappeared.Conclusions: Our report illustrates the rare presentation of DIP. Furthermore, for the pulmonary mass, even if appeared hypermetabolic on PET/CT, it is still necessary to make a definite pathological diagnosis before operation, so as to reduce the damage to patients.
Induction of defence-related proteins by selected plant growth regulators and biocontrol agents against guava root knot nematode, Meloidogyne enterolobii
Authors: Ashokkumar N. , Poornima K. , Kalaiarasan P. , Jeyakumar P. , Uma D. , Kavino M. , Dharani S. , Kothai S. 
Published: October 2021

Abstract
Guava is an important edible and economic fruit crop distributed worldwide. It is widely infested with root knot nematode, Meloidogyne enterolobii which plays a vital role in causing economic losses. Several management strategies were performed to enhance the health status of guava and also to reduce root knot nematode infestation. Among the different aspects, application of plant growth regulators on guava plants under nursery conditions against root knot nematode, M. enterolobii was performed. The guava plants were treated with Salicylic acid (100 ppm), Jasmonic acid (100 ppm), and Indole 3-Butyric Acid (1000 ppm) alone and in combination of two and three. The result of this study revealed that IBA at 1,000 ppm alone (T3) and combined application of plant growth regulators viz., (T4) – Salicylic acid (100 ppm) + Jasmonic acid (100 ppm) + Indole 3-Butyric Acid (1,000 ppm) showed reduction in the nematode population and establishment of new roots (compensatory) and tertiary roots. The combined application of PGRs also increased the Plant height, root length, chlorophyll index, photosynthetic rate, transpiration rate, stomatal conductance, and chlorophyll fluorescence. The activity of various enzymes like total phenols, peroxidase, polyphenol oxidase, acid phosphatase, and phenylalanine ammonia lyase were influenced and developed resistance against root knot nematode, M. enterolobii. Under field conditions, application of Pochonia chlamydosporia and Purpureocilium lilacinum reduced the nematode infestation besides increasing the yield attributes of guava plants.
Permodelan Spasial pada Analisis Faktor yang Mempengaruhi Tingkat Pengangguran Terbuka Provinsi Bangka Belitung Tahun 2018
Authors: Mahmud Apriliansyah , Pasaribu Ernawati 
Published: October 2021

Unemployement is a multidimensional problem that have wide impact into progress and quality of one area. Based on that problem, it is necessary to have an analysis of factor that affected this phenomena. One economy phenomenon of one area can be influenced by neighborhood economy activity. The purpose of this study is to know factors that affected open unemployemnet rate also answer the problem of neighborhood effect by spatial model. Based on result, variables that having spatial effect are open unemployement rate, count of poor citizen, and also gross domestic product. Beside of that, it is also known that error spatial model is feasible to be a model because having smallest AIC score.
Possibility, imagination and conception [Possibilidade, imaginação e concepção]
Authors: Béziau Jean-Yves 
Published: October 2021

In this paper we investigate the relations between possibility, imagination and conception. We develop a theory according to which these three notions are compatible but independent. This means in particular that none of these notions reduces to another one and that there are things which are: (1) imaginable but neither possible nor conceivable; (2) conceivable but neither possible nor imaginable; (3) possible but neither imaginable nor conceivable. We first explain our methodology: structuralism, equilibrium between norm and description, prototypical examples. And then we proceed.
COVID-19: Mechanisms of the Antiviral Activities of Selective Antibiotics Targeting the Human 80S Ribosome
Authors: Hountondji Codjo , Poupaert Jacques H. , Aguida Blanche , Saga Fulbert K. Agbo , Pothier Joël , Créchet Jean-Bernard , Cocks Cédrick , Barty Lionel , Kassehin Urbain C. , Gbaguidi Fernand A. 
Published: October 2021

Background:
The majority of scientists, physicians, and healthcare professionals were trained with the paradigm: “antibiotics are for bacteria only !”, because they misunderstood the definition of the ribosome targeting antibiotics. In the context of the current worldwide COVID-19 pandemic, it might be useful to recall as precisely as possible the definition of the word antibiotic and provide evidence that some classes of antibiotics could offer excellent means to counteract viral infections via specific mechanisms.

Methods:
Molecular modeling and docking studies were used, as well as the tRNAox labeling reaction of the ribosomal protein eL42 in situ on human 80S ribosomes to demonstrate that cycloheximide and its thiosemicarbazone analogues bind to the catalytic Lys-53 residue of the human large subunit ribosomal protein eL42.

Results:
Comparison of the binding sites for Cycloheximide (CHX) and Sparsomycin (SPS) on the evolutionarily conserved E. coli bL12 and S. cerevisiae eL42 by means of molecular modeling and docking studies showed that: (i) SPS binds in proximity to the catalytic Lys-65 residue of the GANK motif of rp bL12 and to the catalytic Lys-55 residue of the GGQTKP motif of rp eL42; (ii) CHX failed to bind to the GANK motif, while the glutarimide moiety of SPS and CHX was found to make contact with Lys-55 of the GGQTKP motif of rp eL42.

Conclusion:
In this report, we demonstrate that cycloheximide and its thiosemicarbazone analogues are capable of inhibiting the human 80S ribosomes selectively through their binding to the ε-amino group of the side chain of Lys-53. As a consequence, these small-molecule inhibitors of translation are susceptible to exhibit antiviral activities by preventing the human ribosomes of the SARS-CoV-2 infected cells from synthesizing the viral proteins and enzymes.
Investigation of Thermal Comfort Changes Using Summer Simmer Index (SSI): A Case Study in Different Climates of Iran
Authors: Asghari Mehdi , Fallah Ghalhari Gholam Abbas , Heidari Hamidreza 
Published: October 2021

Objective:
This study aimed to assess the thermal comfort trend using a metrological parameter based on the Summer Simmer Index (SSI), for different climates of Iran between 1985 and 2014.

Methods:
This is a Time-series study. The new SSI was calculated using metrological data in a 30 year- period for illustrating the changes to the thermal comfort or discomfort level through summer months in different climates of Iran. Mann- Kendall test and Sen's Slope were used to compare the upward or downward trend of the index during this period.

Results:
The worst thermal condition was observed in the southern and central regions of the country. A few stations were put in comfort zone (77≤SSI<83°F). The fluctuations of SSI were not considerable during the study period (P<0.001). However, a commonly upward trend was observed, indicating rising temperature. This initial assessment, which can be reported daily along with other atmospheric parameters at meteorological stations, could play a significant role in reducing the heat-related complications among exposed individuals and a basis for taking appropriate protective measures.

Conclusion:
Based on the results obtained in this study, which has been investigated in Iran for a long period of time, considering intrinsic features of the SSI index, such as ease of calculation and interpretation and also the possibility of calculating the index using daily reported meteorological data, the use of SSI as a screening index of thermal stress in order to adopt preventive policies in outdoor settings in climates of Iran is recommended.
Guidance for Implementing Video Consultations in Danish General Practice: Rapid Cycle Coproduction Study
Authors: Sandbæk Amanda , Christensen Line Due , Larsen Lotte Lykke , Primholdt Christensen Nina , Kofod Frida Greek , Guassora Ann Dorrit , Merrild Camilla Hoffmann , Assing Hvidt Elisabeth 
Published: October 2021

Background
The COVID-19 pandemic has changed various spheres of health care. General practitioners (GPs) have widely replaced face-to-face consultations with telephone or video consultations (VCs) to reduce the risk of COVID-19 transmission. Using VCs for health service delivery is an entirely new way of practicing for many GPs. However, this transition process has largely been conducted with no formal guidelines, which may have caused implementation barriers. This study presents a rapid cycle coproduction approach for developing a guide to assist VC implementation in general practice.

Objective
The aim of this paper is to describe the developmental phases of the VC guide to assist general practices in implementing VCs and summarize the evaluation made by general practice users.

Methods
The development of a guide for VC in general practice was structured as a stepped process based on the coproduction and prototyping processes. We used an iterative framework based on rapid qualitative analyses and interdisciplinary collaborations. Thus, the guide was developed in small, repeated cycles of development, implementation, evaluation, and adaptation, with a continuous exchange between research and practice. The data collection process was structured in 3 main phases. First, we conducted a literature review, recorded observations, and held informal and semistructured interviews. Second, we facilitated coproduction with stakeholders through 4 workshops with GPs, a group interview with patient representatives, and individual revisions by GPs. Third, nationwide testing was conducted in 5 general practice clinics and was followed by an evaluation of the guide through interviews with GPs.

Results
A rapid cycle coproduction approach was used to explore the needs of general practice in connection with the implementation of VC and to develop useful, relevant, and easily understandable guiding materials. Our findings suggest that a guide for VCs should include advice and recommendations regarding the organization of VCs, the technical setup, the appropriate target groups, patients’ use of VCs, the performance of VCs, and the arrangements for booking a VC.

Conclusions
The combination of coproduction, prototyping, small iterations, and rapid data analysis is a suitable approach when contextually rich, hands-on guide materials are urgently needed. Moreover, this method could provide an efficient way of developing relevant guide materials for general practice to aid the implementation of new technology beyond the pandemic period.
Digital Intervention Strategies for Increasing Physical Activity Among Preschoolers: Systematic Review
Authors: Swindle Taren , Poosala Anwesh B , Zeng Nan , Børsheim Elisabet , Andres Aline , Bellows Laura L 
Published: October 2021

Background
Digital interventions are increasingly used to improve health behaviors. Improved access and lower costs (relative to in-person interventions) make such interventions appealing. Specifically, digital platforms may be a promising approach for increasing physical activity (PA) in young children.

Objective
The goal of this systematic review was three-pronged: (1) to determine the quality of studies using digital PA intervention strategies with preschool-aged children (ie, 3 to 5 years old); (2) to assess the efficacy of digital interventions and approaches designed to improve PA in preschool-aged children; and (3) to examine theoretical application and implementation outcomes with current approaches to digital PA interventions.

Methods
This review identified and summarized studies on digitally supported interventions for promoting PA in preschool-aged children. We generated 3 lists of relevant search terms that included technology-related terms, PA-related terms, and weight-related terms. The search included Ovid MEDLINE(R) and Epub Ahead of Print, In-Process & Other Non-Indexed Citations, and Daily, Ovid EMBASE, Ovid Cochrane Central Register of Controlled Trials, Ovid Cochrane Database of Systematic Reviews, and Scopus. Study selection was led by a single author and verified by a second; the same 2 authors assessed study quality using a standardized tool, and 3 authors completed data extraction on PA outcomes, theory application, and implementation outcomes.

Results
In total, 601 studies were identified; 8 met the inclusion criteria. For study quality, only 2 studies received an overall rating of strong quality and low risk of bias. All but 1 study had a small sample size (<100). Positive and significant changes in child PA outcomes were reported in only 2 studies with weak overall quality, both of which used child-directed approaches. In total, 5 studies applied a behavioral theory for designing the intervention; no patterns of effectiveness were identified based on the application of theory. Finally, no studies reported on the implementation outcomes of adoption, cost, penetration, or sustainability; 1 study did not assess any implementation outcomes, and no single study reported on more than 2 implementation outcomes. Studies measured the implementation outcome of acceptability most frequently (n=4), and researchers assessed fidelity in 3 studies.

Conclusions
The interventions with a significant effect on PA used child-centered activities; parent-directed digital interventions alone were ineffective for improving PA. Future research with rigorous designs, monitoring of implementation outcomes, and testing of the contributions of digital components will advance understanding of the effectiveness of digital interventions for increasing PA in children.
Accelerating the Appropriate Adoption of Artificial Intelligence in Health Care: Protocol for a Multistepped Approach
Authors: Wiljer David , Salhia Mohammad , Dolatabadi Elham , Dhalla Azra , Gillan Caitlin , Al-Mouaswas Dalia , Jackson Ethan , Waldorf Jacqueline , Mattson Jane , Clare Megan , Lalani Nadim , Charow Rebecca , Balakumar Sarmini , Younus Sarah , Jeyakumar Tharshini , Peteanu Wanda , Tavares Walter 
Published: October 2021

Background
Significant investments and advances in health care technologies and practices have created a need for digital and data-literate health care providers. Artificial intelligence (AI) algorithms transform the analysis, diagnosis, and treatment of medical conditions. Complex and massive data sets are informing significant health care decisions and clinical practices. The ability to read, manage, and interpret large data sets to provide data-driven care and to protect patient privacy are increasingly critical skills for today’s health care providers.

Objective
The aim of this study is to accelerate the appropriate adoption of data-driven and AI-enhanced care by focusing on the mindsets, skillsets, and toolsets of point-of-care health providers and their leaders in the health system.

Methods
To accelerate the adoption of AI and the need for organizational change at a national level, our multistepped approach includes creating awareness and capacity building, learning through innovation and adoption, developing appropriate and strategic partnerships, and building effective knowledge exchange initiatives. Education interventions designed to adapt knowledge to the local context and address any challenges to knowledge use include engagement activities to increase awareness, educational curricula for health care providers and leaders, and the development of a coaching and practice-based innovation hub. Framed by the Knowledge-to-Action framework, we are currently in the knowledge creation stage to inform the curricula for each deliverable. An environmental scan and scoping review were conducted to understand the current state of AI education programs as reported in the academic literature.

Results
The environmental scan identified 24 AI-accredited programs specific to health providers, of which 11 were from the United States, 6 from Canada, 4 from the United Kingdom, and 3 from Asian countries. The most common curriculum topics across the environmental scan and scoping review included AI fundamentals, applications of AI, applied machine learning in health care, ethics, data science, and challenges to and opportunities for using AI.

Conclusions
Technologies are advancing more rapidly than organizations, and professionals can adopt and adapt to them. To help shape AI practices, health care providers must have the skills and abilities to initiate change and shape the future of their discipline and practices for advancing high-quality care within the digital ecosystem.

International Registered Report Identifier (IRRID)
PRR1-10.2196/30940
Skrankepaver eller læringskatalysatorer?
Authors: Fugl Jette , Lund Tina 
Published: October 2021

DEBAT: Måske skal vi først og fremmest definere, hvad et læringsmiljø er i bibliotekssammenhænge?
Artiklens forfatterne er dykket ned i rapporten "Analyse af fremtidens behov for forskningsbiblioteksbetjening", udgivet for Kulturministeriet og Uddannelses- og Forskningsministeriet af analyseinstitutet Oxford Research.
Prevalence dynamics of uropatogens and antimicrobial resistance determinants in children's significant bacteriuria in 2017 and 2019: a monocenter study
Authors: Shedko E. D. , Lazareva A. V. , Zorkin S. N. , Novikova I. E. , Vershinina V. G. , Timoshina O. Yu. , Goloveshkina E. N. , Fisenko A. P. , Akimkin V. G. 
Published: October 2021

Urinary tract infections are the second most common infections in children with spreading of antimicrobial resistance among uropathogens currently poses a high epidemiological threat.Purpose. Analysis of species prevalence and the presence of genetic determinants of antibiotic resistance.Materials and methods. In the study 215 midstream urine samples were retrospectively analyzed. Samples were obtained during 2017 and 2019 from patients aged 4 weeks to 17 years at the National Medical Research Center for Children's Health Federal State Autonomous Institution of the Ministry of Health of the Russian Federation.Results. Species of pathogen were identified in 93 samples, while the bacterial composition of other samples was classified as «intestinal flora» (n = 17), «coccus flora» (n = 16) or «mixed flora» (n = 89). The most common types of uropathogens in monopathogenic infections in 2017 and 2019 were Escherichia coli (37.5% and 29.2%, respectively). Among infections caused by multiple pathogens, the most common etiological agents were Pseudomonas aeruginosa and Staphylococcus spp. Among all studied samples, 31.9% contained CTX-M-like genes, 5% VIM genes, 1.8% NDM genes, and 3.0% — OXA-48-like genes, and 5.6% of samples contained two and more genetic determinants associated with resistance, with the most prevalent gene combination being the combination of CTX-M- and OXA-48-like genes. In 69 samples with identified species of uropathogens, resistance profile to antimicrobial, determined by microbiological methods, correlated with detected resistance genetic determinants.Conclusion. Authors suggest that introduction of testing for the presence of genes associated with antibacterial resistance to general clinical practice would not only provide an opportunity to conduct epidemiological monitoring of the genetic determinants of antibiotic resistance, but also provide an opportunity to select the correct timely treatment of childhood bacteriuria caused by antibiotic-resistant infectious agents.
The influence of the self-isolation regime on the prevalence of infectious diseases in children living in urban and rural areas
Authors: Britkova Т. A. , Isaeva P. V. , Nizamova G. F. 
Published: October 2021

Relevance: Infectious diseases are one of the most pressing problems in pediatrics, in particular the COVID-19 pandemic has had a huge impact on society and health.Purpose of the work: to analyze the frequency of infectious diseases in children of the Udmurt Republic during a pandemic of a new coronavirus infection using the example of rural and urban areas.Materials and methods: a statistical analysis of the official medical documentation (form No. 12) of the Udmurt Republic «Mozhginskaya regional hospital of the Ministry of Health of the Udmurt Republic» and the Budgetary Establishment of Health of the Udmurt Republic Alnash District Hospital of the Ministry of Health of the Udmurt Republic for 2019—2020 for children with infectious diseases up to 14 years old inclusive was carried out.Result: the incidence of infectious diseases decreased: in Mozhga it decreased by one third (33%) compared to the previous year (13889 and 9318 cases); in Al-nash experienced a more significant reduction in 2 times (3618 and 1513 cases, respectively). The rate of decline in Mozhga was 33%. The maximum values are traced among the following nosologies: influenza, viral hepatitis, meningococcal infections (the rate of decline was 100%). In Alnash, the rate of decline was 58%, the highest rates were in laryngitis and tracheitis (the rate of decline was 73%). The downward trend in infectious pathology during a pandemic is similar in urban and rural areas.Conclusion: restrictive measures against COVID-19 contributed to a decrease in the incidence of infectious pathology, which is more transmitted by airborne droplets, but also spread by fecal-oral and contact-household routes. Studying the characteristics of the incidence of infectious diseases during the period of self-isolation can help doctors control the level of morbidity in the future.