bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global research on nanomaterials for liver cancer from 2004 to 2023: a bibliometric and visual analysis
Authors: Fan Yitao , Xiao Han , Wang Yan , Wang Shuhan , Sun Hui 
Published: December 2024

Abstract
Background
Primary liver cancer, particularly hepatocellular carcinoma, is one of the most common gastrointestinal cancers. An increasing number of studies indicate that nanomaterials play a significant role in the diagnosis and treatment of liver cancer. However, despite the extensive and diverse research on nanomaterials and liver cancer, bibliometric studies in this field have not yet been reported. This study aims to comprehensively evaluate the application prospects and development trends of nanomaterials in primary liver cancer over the past 20 years. By elucidating the current state of research on liver cancer, we intend to provide valuable reference information for researchers in this field.

Methods
We conducted a comprehensive search of the Web of Science Core Collection for publications related to liver cancer and nanomaterials from January 1, 2004, to December 31, 2023. Relevant literature was selected based on specific inclusion and exclusion criteria. These selected publications were subsequently analyzed using CiteSpace, VOSviewer, and the R package "bibliometrix" to identify trends, influential countries, institutions, authors, journals, and research hotspots in this field.

Results
This study included a total of 1641 publications, with an annual growth rate of 25.45%. China and the United States are leading in this field, accounting for 67.46% and 11.27% of the total publications, respectively. The Chinese Academy of Sciences and Shao D are the most cited institution and author, respectively. The International Journal of Nanomedicine is the most influential journal in this field, while Biomaterials is the most highly cited and co-cited journal. Research hotspots mainly focus on improving drug delivery efficiency, inducing cancer cell apoptosis, photodynamic therapy, photothermal therapy, and combination treatments. Emerging research directions include the tumor microenvironment, polyethylene glycol, and immunogenic cell death.

Conclusion
The results of this study indicate that the application of nanomaterials in the field of liver cancer is gradually becoming a significant research area, with a focus on improving drug delivery efficiency, enhancing therapeutic efficacy, and reducing side effects.
Significance of fracture toughness for linear friction welded joint of weathering steel
Authors: Shimizu Kazuma , Nakayama Shota , Shoji Hiroto , Kawakubo Takumi , Nagira Tomoya , Ohata Mitsuru , Fujii Hidetoshi 
Published: December 2024

Abstract
This paper examined the characteristics and significance of fracture toughness for LFW (linear friction welding) joints of weathering steel SPA-H processed under different joining conditions to control maximum temperature during LFW process. Two types of LFW joint were prepared; one was jointed under higher compressive pressure so as a maximum temperature during LFW process to be lower than the A1-transformation temperature (A1-LFW), and the other was jointed under lower compressive pressure to be higher than the A3-transformation temperature (A3-LFW). The fracture toughness of both joints where a crack was located at the joint interface exhibited a higher value than that of the heat-affected zone of MAG (metal active gas) welds for the same steel. These results indicated that the LFW was more effective for the joining of weathering steel compared with conventional arc welding in terms of fracture toughness. However, A1-LFW exhibited lower fracture toughness (critical CTOD) than that of base metal or A3-LFW. Thus, the significance of the test results was discussed from mechanical and metallurgical viewpoints. The fracture toughness for A1-LFW found to be deteriorated due to work hardening associated with compressive plastic straining during LFW under higher compressive pressure, where the metal heated under A1-temperature was not completely ejected by friction but remained around the joint interface. On the other hand, the deterioration of fracture toughness for A3-LFW was found to be caused by hardening due to bainitic transformation near the joint interface, whereas the narrowness of the hardened region provided a little bit higher toughness than the intrinsic toughness of the transformed phase due to plastic constraint loss.
Thermoelectric Modulation of Neat Ti3C2Tx MXenes by Finely Regulating the Stacking of Nanosheets
Authors: Tang Junhui , Zhu Renyang , Pai Ya-Hsin , Zhao Yan , Xu Chen , Liang Ziqi 
Published: December 2024

AbstractEmerging two-dimensional MXenes have been extensively studied in a wide range of fields thanks to their superior electrical and hydrophilic attributes as well as excellent chemical stability and mechanical flexibility. Among them, the ultrahigh electrical conductivity (σ) and tunable band structures of benchmark Ti3C2Tx MXene demonstrate its good potential as thermoelectric (TE) materials. However, both the large variation of σ reported in the literature and the intrinsically low Seebeck coefficient (S) hinder the practical applications. Herein, this study has for the first time systematically investigated the TE properties of neat Ti3C2Tx films, which are finely modulated by exploiting different dispersing solvents, controlling nanosheet sizes and constructing composites. First, deionized water is found to be superior for obtaining closely packed MXene sheets relative to other polar solvents. Second, a simultaneous increase in both S and σ is realized via elevating centrifugal speed on MXene aqueous suspensions to obtain small-sized nanosheets, thus yielding an ultrahigh power factor up to ~ 156 μW m−1 K−2. Third, S is significantly enhanced yet accompanied by a reduction in σ when constructing MXene-based nanocomposites, the latter of which is originated from the damage to the intimate stackings of MXene nanosheets. Together, a correlation between the TE properties of neat Ti3C2Tx films and the stacking of nanosheets is elucidated, which would stimulate further exploration of MXene TEs.
NiNC Catalysts in CO2-to-CO Electrolysis
Authors: Zhang Hao , Qi Menghui , Wang Yong 
Published: December 2024

AbstractCO2-to-CO electrolyzer technology converts carbon dioxide into carbon monoxide using electrochemical methods, offering significant environmental and energy benefits by aiding in greenhouse gas mitigation and promoting a carbon circular economy. Recent study by Strasser et al. in Nature Chemical Engineering presents a high-performance CO2-to-CO electrolyzer utilizing a NiNC catalyst with nearly 100% faradaic efficiency, employing innovative diagnostic tools like the carbon crossover coefficient (CCC) to address transport-related failures and optimize overall efficiency. Strasser’s research demonstrates the potential of NiNC catalysts, particularly NiNC-IMI, for efficient CO production in CO2-to-CO electrolyzers, highlighting their high selectivity and performance. However, challenges such as localized CO2 depletion and mass transport limitations underscore the need for further optimization and development of diagnostic tools like CCC. Strategies for optimizing catalyst structure and operational parameters offer avenues for enhancing the performance and reliability of electrochemical CO2 reduction catalysts.
Carbon Dots-Modified Hollow Mesoporous Photonic Crystal Materials for Sensitivity- and Selectivity-Enhanced Sensing of Chloroform Vapor
Authors: Liu Junchen , Liu Ji , Li Zhipeng , Zhao Liupeng , Wang Tianshuang , Yan Xu , Liu Fangmeng , Li Xiaomin , Li Qin , Sun Peng , Lu Geyu , Zhao Dongyuan 
Published: December 2024

AbstractChloroform and other volatile organic pollutants have garnered widespread attention from the public and researchers, because of their potential harm to the respiratory system, nervous system, skin, and eyes. However, research on chloroform vapor sensing is still in its early stages, primarily due to the lack of specific recognition motif. Here we report a mesoporous photonic crystal sensor incorporating carbon dots-based nanoreceptor (HMSS@CDs-PCs) for enhanced chloroform sensing. The colloidal PC packed with hollow mesoporous silica spheres provides an interconnected ordered macro-meso-hierarchical porous structure, ideal for rapid gas sensing utilizing the photonic bandgap shift as the readout signal. The as-synthesized CDs with pyridinic-N-oxide functional groups adsorbed in the hollow mesoporous silica spheres are found to not only serve as the chloroform adsorption sites, but also a molecular glue that prevents crack formation in the colloidal PC. The sensitivity of HMSS@CDs-PCs sensor is 0.79 nm ppm−1 and an impressively low limit of detection is 3.22 ppm, which are the best reported values in fast-response chloroform vapor sensor without multi-signal assistance. The positive response time is 7.5 s and the negative response time 9 s. Furthermore, relatively stable sensing can be maintained within a relative humidity of 20%–85%RH and temperature of 25–55 °C. This study demonstrates that HMSS@CDs-PCs sensors have practical application potential in indoor and outdoor chloroform vapor detection.
Euphorbia neriifolia extracts as green corrosion inhibitors for aluminium in hydrochloric and nitric acid media
Authors: Meena Omprakash , Kaushal Sandeep , Kumar Sanjeev , Dalal Jasvir 
Published: December 2024

AbstractAmong the new, significant approaches for preventing corrosion in contemporary culture is using green corrosion inhibitors, which lower corrosion rates to an acceptable level with minimal negative effects on the environment. This area of investigation has witnessed substantial advancements from the environmental sustainability perspective. This study investigates the corrosion inhibition potential of Euphorbia neriifolia extracts on aluminium in various concentrations of hydrochloric acid (HCl) and nitric acid (HNO₃) using weight loss, thermometric methods, and Field Emission Scanning Electron Microscopy (FESEM) analysis. The weight loss method revealed maximum inhibition efficiencies of 94.92% and 92.62% for the stem extract at a concentration of 0.7% in 1 M HCl and 1 M HNO₃, respectively. The Langmuir adsorption isotherm indicated a strong linear relationship between surface coverage and inhibitor concentration, suggesting favorable monolayer adsorption on the aluminum surface. Thermometric analysis confirmed the efficacy of the extracts, with a significant reduction in corrosion rates from 157.89 mm/yr in the absence of inhibitors to 0.0099 mm/yr with the optimal concentration of stem extract in 1 M HCl. FESEM images illustrated a marked difference in surface morphology, revealing a smooth, intact surface in the presence of the extracts compared to rough, pitted surfaces in the control samples exposed solely to acidic environments. This work demonstrates the high efficacy and potential modes of action through adsorption of Euphorbia neriifolia extracts, drawing attention to their intriguing use as environmentally benign corrosion inhibitors. The results offer a new, biodegradable substitute for traditional synthetic inhibitors and add to the expanding corpus of research supporting sustainable corrosion management techniques.
Graphical Abstract
Combining immunogenic cell death and cuproptosis to construct a prognostic signature and predict the immune status and treatment efficacy for hepatocellular carcinoma
Authors: Feng Xin , Li Xiaoying , Zhang Xin 
Published: December 2024

Abstract
Background
Immunogenic cell death (ICD) is defined as cell death sufficient to activate an adaptive immune response in an immunocompetent host. Cuproptosis is induced by increased intracellular toxicity due to copper ion accumulation. ICD and cuproptosis have great potential in regulating the growth and proliferation of cancer cells.

Methods
We used transcriptome data from TCGA database to identify two subtypes based on consensus clustering and explored the differences between the two groups. We further combined ICD- and cuproptosis-related genes to develop a signature and predict OS, immune status, and treatment responses in HCC patients. An ICGC cohort was used for external validation.

Results
Patients in the groups with high expression of ICD- and cuproptosis-related genes had higher levels of immune cell infiltration and a better immunotherapeutic response. Eight related genes (BAX, HSP90AA1, IFNB1, LY96, NT5E, LIPT1, DLAT, and CDKN2A) were screened for the prognostic signature. The survival analysis revealed that patients in the low-risk group were less likely to die at an early stage than were those in the high-risk group. The signature also showed better results in predicting immune cell infiltration and the treatment response.

Conclusions
Our study revealed that the prognostic signature constructed by combining ICD- and cuproptosis-related genes performs well in predicting the survival of patients with HCC and is closely associated with immune cell infiltration and immunotherapy.
Variations of rumen metagenome and metabolome in dairy cows with different feed intake levels during the postpartum period
Authors: Huang Shuai , Shang Yikui , Wang Lan , Wang Shang , Zheng Gang , Wang Dongxing , Wang Musen , Li Shengli 
Published: December 2024

Abstract
Feed intake, a critical factor for dairy cows during the postpartum period, is intricately linked to the rumen microbiome. However, the specific roles of rumen metagenome and metabolome in modulating feed intake in postpartum dairy cows remain unclear. In the current study, 20 postpartum dairy cows were divided into low feed intake (n = 5) and high feed intake (HFI, n = 5) groups to investigate the role of ruminal microbial composition, function, and metabolism on feed intake using a combined approach of metagenomics and metabolomics. Our analysis revealed a significant enrichment of Bacteroides and Fibrobacter in HFI cows (p < 0.05), contributing to enhanced protein and energy metabolism. Metabolomic analysis disclosed that HFI cows exhibited a higher relative concentration of rumen metabolites, such as alpha-tocopheryl acetate (fold change = 9.2, p = 0.008), linoleic acid (fold change = 5.96, p = 0.007), and leucine (fold change = 4.14, p = 0.004). Spearman correlation analysis pinpointed a positive correlation between specific microbiota (Succinivibrionaceae and Prevotellaceae) and metabolites involved in amino acid and peptide metabolism, fatty acid metabolism, and conjugates. Furthermore, co-occurrence network analysis showed that the unclassified_f_Succinivibrionaceae, Succinatimonas, and Ruminobacte were significantly associated with dry matter intake-associated metabotypes, including rumen metabolites involved in fatty acids and conjugates, favonoids, and gycerophosphocholines. The feed intake variation explained by the rumen microbiome, functions, and metabolites were 29.63%, 27.30%, and 33.50%, respectively. These findings provide comprehensive insights into rumen metagenomics at different feed intake levels in postpartum dairy cows, potentially guiding strategies to manipulate the rumen microbiome for feed intake and production improvement.
Hospital antimicrobial stewardship funding and resourcing impact on broad-spectrum antibiotic use: a cross-sectional study
Authors: Tu Megan , Shi Zong Heng , Leung Valerie , Brown Kevin A , Schwartz Kevin L , Daneman Nick , Langford Bradley J 
Published: December 2024

Abstract

Background:
Antimicrobial stewardship programs (ASPs) aim to mitigate antimicrobial resistance (AMR) by optimizing antibiotic use including reducing unnecessary broad-spectrum therapy. This study evaluates the impact of ASP funding and resources on the use of broad-spectrum antibiotics in Ontario hospitals.

Methods:
We conducted a cross-sectional study of antimicrobial use (AMU) across 63 Ontario hospitals from April 2020 to March 2023. The Ontario ASP Landscape Survey provided data on ASP resourcing and antibiotic utilization. The main outcome was the proportion of all antibiotics that were broad-spectrum, defined as: fluoroquinolones; third-generation cephalosporins; beta-lactam/beta-lactamase inhibitors; carbapenems; clindamycin; and parenteral vancomycin. Secondary outcomes included the proportions of individual antibiotic classes listed above and anti-pseudomonal agents. Statistical analysis involved logistic regression to determine the odds ratio (OR) of the association between ASP funding/resourcing and broad-spectrum antibiotic use.

Results:
Among 63 hospitals, 48 reported designated ASP funding/resources. Median broad-spectrum antibiotic use was 52.5%. ASP funding/resources was not associated with overall broad-spectrum antibiotic use (0.97, 95% CI: 0.75–1.25, P = 0.79). However, funding was associated with lower use of fluoroquinolones (OR 0.67, 95% CI: 0.46–0.96, P = 0.03), clindamycin (OR 0.69, 95% CI: 0.47–1.00, P = 0.05), and anti-pseudomonal agents (OR 0.76, 95% CI: 0.59–0.98, P = 0.03).

Conclusion:
The presence of designated funding and resources for hospital ASPs is linked to reduced use of specific broad-spectrum antibiotics but not overall broad-spectrum antibiotic use. Enhancing ASP resourcing may be an important factor in limiting targeted antibiotic use, thereby increasing the effectiveness of efforts to mitigate AMR.
Completion of a standardizable competency-based research training program improves understanding and preparedness for both new and experienced clinical research professionals
Authors: Palmer Lucy , Morones Sandra E. , Jacobe Heidi T. , Oilepo Rhonda 
Published: December 2024

Abstract
Clinical research professionals (CRPs) are integral to the academic medical center workforce, research operations, and daily clinical research tasks; however, due to inconsistent training, there is a shortage of qualified CRPs. The Joint Task Force for Clinical Trial Competency created a competency framework for CRPs, which has demonstrated positive results from various institutions, but training programs have been limited in standardization, replicability, and dissemination. To improve this, we designed the University of Texas Southwestern (UTSW) Medical Center Clinical Research Foundations (CRF) training program, which is a competency-based online self-paced CRP training curriculum hosted via the Collaborative Institutional Training Initiative (CITI) portal. We examined feasibility, acceptability, and uptake of the UTSW CRF training on an institutional scale and were pleased to find this curriculum is not only feasible but has high levels of acceptability. Furthermore, faculty, clinicians, and trainees voluntarily completed this training program indicating utility across diverse groups. The UTSW CRF combines the existing CITI training modules with UTSW-created material, providing an optimal balance between generalized clinical research education and institutionally tailored content. We believe the UTSW CRF curriculum could serve as a plug-and-play foundational model for other research centers to tailor according to their audience and institutional needs.
Droplet impact on a flexible disk
Authors: Zhou Xinping , Xu Yongqi , Zhang Qi , Zhang Wanqiu , Peng Ze-Rui 
Published: December 2024

In this paper, we simulate the process of two-dimensional axisymmetric fluid–structure coupling of a droplet impacting on a flexible disk. The effects of dimensionless disk stiffness (K = 0.1–1000), Weber number (We = 1–500) and contact angle (θ = 130° and 60°) on the dynamics of the droplet impacting on the flexible disk are analysed. The results indicate that there are five typical impact modes for a hydrophobic surface (θ = 130°) and four typical impact modes for a hydrophilic surface (θ = 60°) within the range of considered parameters. The analysis of spreading factor reveals that a part of the energy is transferred to the substrate, which is manifested as a weakening of the droplet spreading, when the substrate deforms downwards due to the droplet impact; the squeezing of the droplet causes a tendency to flow from the centre of the droplet to the edge, which is manifested as an enhancement of the droplet spreading, when the substrate recovers from the downward deformation. The effect of the substrate flexibility on the maximum spreading factor depends on the competition of the two mechanisms above. Based on this, a modified scaling law of βmax has been proposed by introducing the effective Weber number (Wem). The analysis of impact force demonstrates that the peak of the impact force is related to the deflection of the flexible substrate which is different from that of a rigid wall; and three typical processes of impact force variation have been summarised. In addition, unlike the rigid substrate scenario, there is an energy interaction between the droplet and the flexible substrate after impact occurs, which is classified as three typical energy transformation processes.
A NOTE ON THE LARGE SIEVE INEQUALITY FOR MODULI GENERATED BY A QUADRATIC
Authors: CORRIGAN C. C. 
Published: December 2024

Abstract
We develop a generalisation of the square sieve of Heath-Brown and use it to give an alternate proof of one of the large sieve inequalities in our previous paper [‘A large sieve inequality for characters to quadratic moduli’, Preprint, https://web.maths.unsw.edu.au/~ccorrigan/preprint6.pdf].
PRIMITIVE IDEAL SPACE OF
$C^*(R_+)\rtimes R^\times $
Authors: CHEN XIAOHUI , LI HUI 
Published: December 2024

Abstract
For an integral domain R satisfying certain conditions, we characterise the primitive ideal space and its Jacobson topology for the semigroup crossed product

$C^*(R_+) \rtimes R^\times $

. We illustrate the result by the example

$R=\mathbb {Z}[\sqrt {-3}]$

.
Regiomontanus's Paduan lecture of 1464, the Byzantine intellectual heritage and the Graeco-Arabic roots of astronomical studies in early modern Italy
Authors: Bardi Alberto 
Published: December 2024

Abstract
The inaugural lecture, or oration, delivered by Regiomontanus at the University of Padua in 1464 is deemed a document of remarkable significance in the history of science. Although it has attracted much scholarly attention, few efforts have been directed towards identifying the traces of Byzantine influence it might carry; that is to say, the extent to which Regiomontanus might have been influenced by the views of his patron, Bessarion. This paper responds to the need for such a study, arriving at the following conclusions. First, Regiomontanus's praise of astrology is in line with Bessarion's reaction to the official decisions taken against astrology in Constantinople at the Council of 1351 – decisions which were ultimately rooted in the hesychast controversy and in the confessional struggles between the Churches of Constantinople and Rome. Second, the legitimation of the Graeco-Arabic roots of astronomy in an institutional context, as undertaken by Regiomontanus, is in accordance with the intellectual influences Bessarion had absorbed in his youth in Constantinople. Third, contrary to some claims, it is likely that Regiomontanus does not adhere to a humanist anti-Arab agenda; rather, his views on the history of mathematics are a consequence of the Graeco-Arabic heritage of his patron, and of his lack of access to Arabic translations.