bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age-dependent appearance of SARS-CoV-2 entry cells in mouse chemosensory systems reflects COVID-19 anosmia and ageusia symptoms
Authors: Brechbühl Julien , Wood Dean , Bouteiller Sofiane , Lopes Ana Catarina , Verdumo Chantal , Broillet Marie-Christine 
Published: March 2021

AbstractCOVID-19 pandemic has given rise to a collective scientific effort to study its viral causing agent SARS-CoV-2. Research is focusing in particular on its infection mechanisms and on the associated-disease symptoms. Interestingly, this environmental pathogen directly affects the human chemosensory systems leading to anosmia and ageusia. Evidence for the presence of the cellular entry sites of the virus, the ACE2/TMPRSS2 proteins, has been reported in non-chemosensory cells in the rodent’s nose and mouth, missing a direct correlation between the symptoms reported in patients and the observed direct viral infection in human sensory cells. Here, mapping the gene and protein expression of ACE2/TMPRSS2 in the mouse olfactory and gustatory cells, we precisely identified the virus target cells to be of basal and sensory origin and we revealed their age-dependent appearance. Our results not only clarify human viral-induced sensory symptoms but also propose new investigative perspectives based on ACE2-humanized mouse models.
How do consumers respond to price gaps in private brand agrifood products?
Authors: Salazar-Ordóñez Melania , Rodríguez-Entrena Macario , Arriaza Manuel 
Published: March 2021

PurposeThere is a range around reference prices, the so-called latitude of price acceptance, where consumers seem insensitive to changes into prices, with these ranges being wider for buyers of private brands. This paper analyses objective price gap between two product alternatives as a main driver of consumer behaviour. Therefore, the authors shed light on whether the price gap conditions consumer-switching behaviour and at what point the price gap triggers a switching pattern.Design/methodology/approachShopping data on two product alternatives of olive oil were obtained from a household scanner panel of Spanish consumers (607 households) with weekly price tracking, and multilevel regression models were performed.FindingsThe results suggest that the price gap has a fundamental effect on the consumers' choice. In this case, up to 1 euro/litre the demand seems almost inelastic; beyond that price gap, the demand for the finer product plummets.Research limitations/implicationsThis study focussed on olive oil products. The research needs to be extended other food products.Originality/valueThe authors contribute to the literature by documenting how the price context measured in terms of a price gap is a relevant stimulus in consumer choices, with a focus on the change in price sensitivity between product alternatives when competing brands are not involved but private brands are.
The role of technical efficiency, market competition and risk in the banking performance in G20 countries
Authors: Zhao Yaoteng , Chupradit Supat , Hassan Marria , Soudagar Sadaf , Shoukry Alaa Mohamd , Khader Jameel 
Published: March 2021

PurposeRecently, the financial sector has faced significant challenges regarding the market competition, its technical efficiency and risk factors around the globe and gain recent researchers' intentions. Thus, the present study aims to examine the impact of technical efficiency, market competition and risk in banking performance in Group of Twenty (G20) countries.Design/methodology/approachData have been obtained from the World Development Indicator from 2008 to 2019. For analysis purpose, random effect model and generalized method of moments (GMMs) have been executed using Stata.FindingsThe results revealed that market competition and banks' capital efficiency have a positive impact on banking performance, while banks' lending efficiency and non-performing loans have a negative association with the banking sector performance of G20 countries. These outcomes provide the guidelines to the regulators that they should formulate the effective policies related to the lending practices and non-performing loans that could improve the banking sector performance worldwide.Research limitations/implicationsThe study has examined only three economic factors like the technical efficiency rate, market competition and risk element, and their influences on banking institutions' operational and economic performance. But the analysis has proved that except these factors, several factors affect banking institutions' operational and economic performance. Thus, future scholars recommend they analyze all the banking sector areas, pick more factors and enlighten their operational and economic performance influences. Moreover, the author of this article has chosen a particular source for collecting data to meet his study's objective. Only a single piece of software has been applied to analyze data; thus, the data collected for this paper may be incomplete, lack accuracy and reliability. Therefore, the future authors are recommended to use multiple sources to collect data and its analysis to ensure the comprehension, completeness and accuracy.Originality/valueLast but not least, this study with the evidences from the banking sector of G20 countries tries to show on the banking management how the risk element matters in the banking sector in an economy. It makes it clear in which areas the banking institutions may be exposed to the risks, and how much sever different kinds of risks may be. Thus, it motivates the management to set a body of persons within the organization to monitor the risks, to try to avoid them and to overcome the problems created by these risks events.
A multimodal induction model for beginning teachers: a narrative approach
Authors: van Tonder Gideon Petrus 
Published: March 2021

PurposeThe researcher emphasised with current research the need for an induction programme for beginning teachers in the South African context to overcome the challenges experienced by beginning teachers while bridging from pre-service teaching to in-service teaching and to introduce and illuminate the design of a new multimodal induction model.Design/methodology/approachThe researcher followed a narrative approach by discussing previous research regarding the insufficient pre-service training beginning teachers received and the lack of a structured induction programme in the South African context.FindingsResearch has shown that South African beginning teachers have faced similar difficulties as beginning teachers worldwide, but South African beginning teachers are not subjected to formal induction programmes. While the South African Department of Basic Education offered guidelines for the beginning teacher orientation programme, there is almost no evidence in the literature that schools follow such guidelines.Research limitations/implicationsThe implications of this paper give other researchers in this field a broader perspective on how the new multimodal induction model can make a measurable contribution to the school, the mentor, the beginning teacher and, most importantly, the learner.Practical implicationsThe Department of Basic Education in South Africa and Principals need to follow the guidelines of this multimodal induction model to retain beginning teachers and improve the performance of learners.Originality/valueThis is a new model developed by the researcher to explore the benefits of promoting excellence in the teaching profession through a technology-rich, integrated induction programme to increase the productivity, retention and leadership of beginning teachers, enhance and prevent the loss of human capital, with the ultimate goal of improving learners' growth and performance.
Organic agricultural practice enhances arbuscular mycorrhizal symbiosis in correspondence to soil warming and altered precipitation patterns
Authors: Wahdan Sara Fareed Mohamed , Reitz Thomas , Heintz‐Buschart Anna , Schädler Martin , Roscher Christiane , Breitkreuz Claudia , Schnabel Beatrix , Purahong Witoon , Buscot François 
Published: March 2021

SummaryClimate and agricultural practice interact to influence both crop production and soil microbes in agroecosystems. Here, we carried out a unique experiment in Central Germany to simultaneously investigate the effects of climates (ambient climate vs. future climate expected in 50–70 years), agricultural practices (conventional vs. organic farming), and their interaction on arbuscular mycorrhizal fungi (AMF) inside wheat (Triticum aestivum L.) roots. AMF communities were characterized using Illumina sequencing of 18S rRNA gene amplicons. We showed that climatic conditions and agricultural practices significantly altered total AMF community composition. Conventional farming significantly affected the AMF community and caused a decline in AMF richness. Factors shaping AMF community composition and richness at family level differed greatly among Glomeraceae, Gigasporaceae and Diversisporaceae. An interactive impact of climate and agricultural practices was detected in the community composition of Diversisporaceae. Organic farming mitigated the negative effect of future climate and promoted total AMF and Gigasporaceae richness. AMF richness was significantly linked with nutrient content of wheat grains under both agricultural practices.
Childhood sexual abuse in patients with severe mental Illness: Demographic, clinical and functional correlates
Authors: Werbeloff Nomi , Hilge Thygesen Johan , Hayes Joseph F. , Viding Essi M. , Johnson Sonia , Osborn David P.J. 
Published: March 2021

AbstractObjectiveTo use data from electronic health records (EHRs) to describe the demographic, clinical and functional correlates of childhood sexual abuse (CSA) in patients with severe mental illness (SMI), and compare their clinical outcomes (admissions and receipt of antipsychotic medications) to those of patients with no recorded history of CSA.MethodsWe applied a string‐matching technique to clinical text records of 7000 patients with SMI (non‐organic psychotic disorders or bipolar disorder), identifying 619 (8.8%) patients with a recorded history of CSA. Data were extracted from both free‐text and structured fields of patients’ EHRs.ResultsComorbid diagnoses of major depressive disorder, post‐traumatic stress disorder and personality disorders were more prevalent in patients with CSA. Positive psychotic symptoms, depressed mood, self‐harm, substance use and aggression were also more prevalent in this group, as were problems with relationships and living conditions. The odds of inpatient admissions were higher in patients with CSA than in those without (adjusted OR = 1.95, 95% CI: 1.64–2.33), and they were more likely to have spent more than 10 days per year as inpatients (adjusted OR = 1.32, 95% CI: 1.07–1.62). Patients with CSA were more likely to be prescribed antipsychotic medications (adjusted OR = 2.48, 95% CI: 1.69–3.66) and be given over 75% of the maximum recommended daily dose (adjusted OR = 1.72, 95% CI: 1.44–2.04).ConclusionData‐driven approaches are a reliable, promising avenue for research on childhood trauma. Clinicians should be trained and skilled at identifying childhood adversity in patients with SMI, and addressing it as part of the care plan.
Clinical outcomes and prognostic factors following the surgical resection of renal cell carcinoma spinal metastases
Authors: Kato Satoshi , Demura Satoru , Murakami Hideki , Yoshioka Katsuhito , Shinmura Kazuya , Yokogawa Noriaki , Shimizu Takaki , Kawahara Norio , Tsuchiya Hiroyuki 
Published: March 2021

AbstractThe efficacy of surgical resection in metastatic renal cell carcinoma is an active and important research field in the postcytokine era. Bone metastases, especially in the spine, compromise patient performance status. Metastasectomy is indicated, if feasible, because it helps to achieve the best clinical outcomes possible compared with other treatments. This study examined the postoperative survival and prognostic factors in patients who underwent metastasectomy of spinal lesions. The retrospective study included 65 consecutive patients with metastatic renal cell carcinomas who were operated on by spinal metastasectomy between 1995 and 2017 at our institution. The cancer‐specific survival times from the first spinal metastasectomy to death or the last follow‐up (≥3 years) were determined using Kaplan‐Meier analysis. Potential factors influencing survival were analyzed using Cox proportional hazard models. Planned surgical resection of all the spine tumors was achieved in all patients. Of these, 38 had complete metastasectomy of all visible metastases, including extraspinal lesions. In all patients, the estimated median cancer‐specific survival time was 100 months. The 3‐, 5‐, and 10‐year cancer‐specific survival rates were 77%, 62%, and 48%, respectively. The survival times after spinal metastasectomy were similar in both cytokine and postcytokine groups. In multivariate analyses, postoperative disability, the coexistence of liver metastases, multiple spinal metastases, and incomplete metastasectomy were significant risk factors associated with short‐term survival. Complete metastasectomy, including extraspinal metastases, was associated with improved cancer‐specific survival. Proper patient selection and complete metastasectomy provide a better prognosis in metastatic renal cell carcinoma patients.
The geographic distribution of retail tobacco outlets in Yogyakarta, Indonesia
Authors: Morrison Christopher N. , Lee Juliet P. , Giovenco Daniel P. , West Brooke , Hidayana Irma , Astuti Putu A. S. , Mooney Stephen J. , Jacobowitz Ahuva , Rundle Andrew 
Published: March 2021

AbstractIntroductionTobacco smoking prevalence in Indonesia is among the highest in the world. Research worldwide identifies that physical access to tobacco through retail outlets is related to increased tobacco smoking. Tobacco outlet density is very high in many Indonesian cities, so tobacco access may contribute to the high prevalence of tobacco use in that country. The aim of this study was to examine distributions of tobacco outlets in one Indonesian city, Yogyakarta, in relation to social and physical environmental conditions.MethodsFor this cross‐sectional ecological study, we virtually audited randomly selected street segments (n = 1099) using Google Street View. The outcome of interest was a count of tobacco advertising banners (indicating the presence of retail outlets). Exposures were physical environmental conditions (scales of main roads, physical decay, presence of schools, mosques, churches) and social conditions measured at the neighbourhood level (concentrated disadvantage, age composition, population density).ResultsTobacco banners were present on 36.4% of sampled street segments, including 55 (37%) of 147 streets with schools; a total of 1381 banners were identified. Multilevel negative binomial regression models for street segments nested within neighbourhoods found the prevalence of tobacco banners per 100 m was lower near schools (RR = 0.66, 95% CI 0.45, 0.97) and was not associated with other exposure measures.Discussion and ConclusionsRetail tobacco outlets are ubiquitous in Yogyakarta. Although they are relatively less prevalent on streets with schools, the high absolute values and wide spatial distribution means all residents of Yogyakarta are exposed to tobacco outlets.
A rare case of quadrileaflet mitral valve and ostium primum atrial septal defect
Authors: Fiore Corrado , Kemaloglu Oz Tugba , Lombardi Luigi , Sinani Rebani , Gregorini Renato , Almaghraby Abdallah 
Published: March 2021

AbstractA 60‐year‐old woman was referred to our clinic for evaluation of her rapidly progressive dyspnea, and she had no previous history of heart disease. A murmur was noted on her examination, and transthoracic echocardiography was so difficult to be performed due to poor acoustic windows so she was referred to do a transesophageal echocardiography that showed an ostium primum atrial septal defect (ASD) with left‐to‐right shunt and a quadrileaflet mitral valve with severe regurgitation. Later on, she underwent surgery with ostium primum ASD closure by a patch and double cleft repair by suture after right heart catheterization.
The value of C‐reactive protein‐to‐albumin ratio in predicting long‐term mortality among HFrEF patients with implantable cardiac defibrillators
Authors: Çinier Göksel , Hayıroğlu Mert İlker , Kolak Zeynep , Tezen Ozan , Yumurtaş Ahmet Çağdaş , Pay Levent , Eren Semih , Çetin Tuğba , Özcan Serhan , Türkkan Ceyhan , Özbilgin Nazmiye , Tekkeşin Ahmet İlker , Alper Ahmet Taha , Gürkan Kadir 
Published: March 2021

AbstractBackgroundPatients with heart failure with reduced ejection fraction (HFrEF) who received implantable cardiac defibrillator (ICD) still remain at high risk due to pump failure and prevalent comorbid conditions. The primary aim of this research was to evaluate the predictive value of C‐reactive protein‐to‐albumin ratio (CAR) for all‐cause mortality among patients with HFrEF despite ICD implantation.Materials and methodsThose who were implanted ICD for HFrEF in our institution between 2009 and 2019 were included. Data were extracted from hospital's database. CAR was calculated as ratio of C‐reactive protein (CRP) to serum albumin concentration. Patients were grouped into tertiles in accordance with CAR at the time of the implantation. During follow‐up duration of 38 [17‐77] months, survival times of tertiles were compared by using Kaplan‐Meier survival method. Forward Cox proportional regression model was used for multivariable analysis.ResultsThousand and eleven patients constituted the study population. Ischaemic cardiomyopathy was the primary diagnosis in 92.3%, and ICD was implanted for the primary prevention among 33.9% of patients. Of those, 14.5% died after the discharge. Patients in tertile 3 (T3) had higher risk of mortality (4.2% vs 11.0% vs 28.5%) compared with those in other tertiles. Multivariable analysis revealed that when patients in T1 were considered as the reference, both those in T2 and those in T3 had independently higher risk of all‐cause mortality. This finding was consistent in the unadjusted and adjusted multivariable models.ConclusionAmong patients with HFrEF and ICD, elevated CAR increased the risk of all‐cause mortality at long term.
Urbanization imprint on land surface phenology: The urban–rural gradient analysis for Chinese cities
Authors: Jia Wenxiao , Zhao Shuqing , Zhang Xiaoyang , Liu Shuguang , Henebry Geoffrey M. , Liu Lingling 
Published: March 2021

AbstractRising temperature shifts plant phenology. Chinese cities, experiencing extensive expansion and intensive warming, spanning a wide latitudinal range, might provide ideal experimental opportunities for observing and predicting phenological responses to warming temperature. Using the urban–rural gradient approach, we explored urbanization imprint on land surface phenology across the entire urbanization intensity (UI) gradient ranging from 0% to 100% in 343 Chinese cities using the VIIRS Land Surface Phenology along with MODIS Land Surface Temperature (LST) products. We found prevalent advancing and delaying trends for the start of the growing season (SOS) and the end of the growing season (EOS) with increasing UI across 343 Chinese cities, respectively. Overall, the phenology shifted earlier by 8.6 ± 0.54 days for SOS, later by 1.3 ± 0.51 days for EOS, and lengthened by 9.9 ± 0.77 days for the growing season length (GSL) in urban core areas (UI above 50%) relative to their rural counterparts (UI lower than 1%). The temperature sensitivity of SOS and EOS was 10.5 ± 0.25 days earlier and 2.9 ± 0.16 days later per 1°C LST increase in spring and autumn, respectively. Moreover, the northern cities witnessed higher temperature sensitivity for SOS and EOS than the southern ones. Both spring and autumn temperature sensitivity across these 343 cities would likely decrease with future urban warming, suggesting any projections of future phenological responses to continued warming must be approached with caution.
Impact of motor subtype on non‐motor symptoms and fall‐related features in patients with early Parkinson's disease
Authors: Kwon Kyum‐Yil , Lee Eun Ji , Lee Mina , Ju Hyunjin , Im Kayeong 
Published: March 2021

AimClinical implications for motor phenotypes of Parkinson's disease (PD) remain to be further elucidated, particularly at the early stages of the disease. We aimed to compare the non‐motor and fall‐related features between tremor‐dominant (TD) and postural instability‐gait difficulty (PIGD) subtypes in patients with early PD.MethodsPD was categorized into TD, intermediate and PIGD types, according to the literature. Not only motor symptoms, but also non‐motor symptoms for global cognition, depression, anxiety, fatigue and dysautonomia, were measured in detail. In addition, fall‐related features, including a previous history of falls, fear of fall measurement and gait freezing were assessed.ResultsIn patients with early PD (disease duration no more than 5 years), 35 patients with TD‐type PD and 31 patients with PIGD‐type PD were finally evaluated for the study. Compared with the TD group, the PIGD group showed higher fatigue, gastrointestinal dysfunction and fall‐related parameter scores. Moreover, the PIGD scores were significantly correlated with all of those symptoms.ConclusionsOur findings suggest that PIGD is significantly linked to fatigue, gastrointestinal dysfunction and fall‐related features during the early stages of PD. Geriatr Gerontol Int 2021; 21: 416–420.
Lessons learned from upper gastrointestinal endoscopy in asymptomatic Chinese
Authors: Huang Yu , Li Huiyi , Long Xiaohua , Liang Xiao , Lu Hong 
Published: March 2021

AbstractBackgroundThe Helicobacter pylori (H. pylori) infection‐related diseases, peptic ulcer, and gastric cancer are frequently asymptomatic until the onset of complications. This study aimed to investigate the prevalence of H. pylori, erosive esophagitis, peptic ulcer, and precancerous lesions such as atrophic gastritis, intestinal metaplasia, gastric dysplasia, and upper gastrointestinal (GI) malignancy in asymptomatic Chinese.MethodsFrom January to December 2017, a questionnaire was administered to consecutive asymptomatic patients undergoing routine physical examination, which included their first screening esophagogastroduodenoscopy. H. pylori infection was determined by one of positive 13C urea breath tests or rapid urease test and histology. The presence of H. pylori infection, erosive esophagitis, peptic ulcer, precancerous gastric histology, and upper GI malignancy was analyzed in relation to demographic factors.ResultsA total of 1108 subjects (mean age: 48, range 21 to 79, 39.5% men) were included. The findings were: erosive esophagitis 7.8%, active H. pylori infection 44%, peptic ulcer 9.1% (duodenal 5.8%, gastric 2.5% or both 0.8%); 0.5% had gastric cancer. Male, smoking history, and current H. pylori infection were all significantly related to the presence of peptic ulcer. Totally, 1095 patients had gastric histopathology and premalignant gastric lesions were present in 67.4%; atrophic gastritis (67.4%), intestinal metaplasia (27.4%), and gastric dysplasia (0.5%). Age, current and previous H. pylori infection were risk factors significantly associated with precancerous lesions.ConclusionsUpper GI pathology as a sequelae of H. pylori infection is common in asymptomatic Chinese. These findings support institution of a nationwide test and treat program to eradicate H. pylori in China.