bluuebunny/crossref_metadata_2025_split huggingface dataset:
The cultural landscape of coffee in Tolima, Colombia: heritage assessment, sustainability and management
Authors: Velandia Silva César Augusto , Diab Mark C. 
Published: October 2021

PurposeThe purpose of this paper is to determine the basis for a management agenda for the Tolima Coffee Cultural Landscape (CCLT) in Colombia. To this end, a delimitation model has been developed. However, the approach taken to institute the agenda of the CCLT, as a comprehensive academic and policy-based theme, is based on the formulation of a social agenda that supports its construction.Design/methodology/approachA theoretical framework is proposed that addresses the sociocultural complexities of the Tolima cultural landscape. This is based on an ethnohistorical approach that elucidates the development of this landscape as a collective construction of pre-Hispanic origin. Therefore, this investigation has been perceived through the theoretical and conceptual framework of the cultural landscape concept and the unique historical and cultural phenomenon that help to define all landscapes. More specifically, the authors have demonstrated the close links that exist between nature and culture, requiring increasingly accurate methods in order to adapt the landscape definition to the specific Latin American context, rather than adhering to the institutional framework proposed by UNESCO.FindingsThe assessment methods currently in use support the interpretation of a set of qualitative and quantitative attributes inherent to the Tolima region. However, additional methods still remain similar to those of the Coffee Cultural Landscape of Colombia (CCLC) that has already been inscribed on UNESCO's World Heritage List. The CCLC is considered to be a representative landscape—or “type” landscape—that “mirrors” the CCLT. Taken as a whole, this theoretical construction combined with the official designation allows local communities to understand the spatial phenomena of the CCLT. This will have the effect of enabling communities at all levels, from local government to landholders and farmers, to authorize its existence and allow for its continuing development and governance. The additional approval for further academic research, combined with the totality of these elements, also has the added effect of empowering communities, their economic future and their cultural interests.Originality/valueThe management agenda that the authors are proposing may form the beginning of regional policy initiatives that reflect a positive strategy for highlighting the value of cultural heritage, thereby ensuring the protection of cultural properties and landscapes and allowing for a more sustainable environment and livelihood for its occupants.
Measuring the motivation to avoid duping: scale development and validation
Authors: Madrigal Robert , Wardley Marcus , Armstrong Soule Catherine Anne 
Published: October 2021

PurposeThis paper aims to develop and validate a psychometrically sound scale measuring buyers’ motivation to avoid being duped (MAD) in a marketplace transaction.Design/methodology/approachStandard scale construction methodology was followed in developing the MAD Scale. Eight studies were conducted.FindingsThree underlying MAD factors were discovered: suspicion of sellers, anticipated aversive emotions and deception detection. For purposes of analyses, data were collapsed across factors. High MAD individuals exhibited more vigilance in decision-making, were less trusting of strangers and displayed a greater desire to appear perfect to others. Those high in MAD were also more apt to have a prevention regulatory focus. Test-retest reliability was satisfactory, and no social desirability bias was observed. Finally, in an economic game with real financial consequences, those higher (vs lower) in MAD invested less after being duped, thus supporting criterion validity.Originality/valueMarketplace deception has been identified as an existential threat facing consumers. Yet, few studies have examined how consumers cope with this threat. There currently exists no scales to measure consumer motivation to avoid being duped. The current research defines MAD and differentiates it from related constructs. The MAD scale will be useful in a variety of research contexts related to marketplace deception.
Applying e-learning system for engineering education – challenges and obstacles
Authors: Abumandour El-Shaimaa Talaat 
Published: October 2021

PurposeAt present, humankind is facing rapid and profound changes in society, science, technology, economy and environment. The 21st century has witnessed extraordinary scientific and technological progressions. Improvement of technology has generated new educational technique known as e-learning. Nowadays, popularity of e-learning is growing rapidly and numerous educational organizations, public, academic and digital libraries are embracing it. Lately, engineering education is heading toward the blended education system as it successfully combines both chalk and talk system (face-to-face), computer-assisted learning methodologies and internet access feature to learners.Design/methodology/approachThis work discusses the potential of e-learning as an educational system for engineering topics and the challenges faced by educational organizations and public libraries as their partners in applying this system for engineering topics. In addition, number of national and international successful engineering e-learning trials that have been created, organized and/or hosted by educational organizations and public libraries are presented.FindingsThe author presents challenges and obstacles that stakeholders, teachers, professors and librarians should be aware of to develop and support the e-learning system. Hence, a number of recommendations are provided to build a bridge linking e-learning and engineering education.Originality/valueThis paper is a complementary work to a previously published study. In this paper, the author sheds light on the link between the e-learning system and the engineering education provided by the educational organizations and hosted by public libraries.
Guest editorial: Solving problems for service consumers experiencing vulnerabilities: a marketplace challenge
Authors: Johns Raechel , Davey Janet 
Published: October 2021

Purpose
While there is burgeoning service literature identifying consumer vulnerabilities and questioning the assumption that all consumers have the resources to co-create, limited research addresses solutions for consumers experiencing vulnerabilities. Service systems can provide support for consumers but can also create inequities and experienced vulnerabilities. This paper aims to identify current and further research needed to explore this issue and addresses marketplace problems for consumers experiencing vulnerabilities.

Design/methodology/approach
This viewpoint discusses key issues relating to solving marketplace problems for consumers experiencing vulnerabilities. A call for papers focused on solving marketplace problems for consumers experiencing vulnerabilities resulted in a large number of submissions. Nine papers are included in this special issue, and each one is discussed in this editorial according to five emergent themes.

Findings
Vulnerabilities can be temporary, or permanent, and anyone can suddenly experience vulnerabilities. Inequities and vulnerabilities can be due to individual characteristics, environmental forces, or due to the structure of the marketplace itself. Solutions include taking a strengths-based approach to addressing inequities and using a multiple-actor network to provide support.

Practical implications
The recommendations addressed in this paper enable more positive approaches to solving marketplace problems for consumers experiencing vulnerabilities.

Social implications
Taking a solutions-focused lens to research relating to vulnerabilities will contribute toward addressing inequities within the marketplace.

Originality/value
Increasingly, service literature is identifying inequities; however, very limited research addresses solutions for solving marketplace problems for consumers experiencing vulnerabilities. This paper suggests taking an approach focusing on strengths, rather than weaknesses, to determine strategies, and using the support of other actors (Transformative Service Mediators) where required.
Robust optimization of EMU brake module based on interval analysis
Authors: Li Yonghua , Yin Hao , Xia Qing 
Published: October 2021

PurposeThis study aims to research the influence of non-probabilistic design variables on interval robust optimization of electric multiple units (EMU) brake module, therefore obtain the reasonable of design variables of the EMU brake module.Design/methodology/approachA robust optimization model of the EMU brake module based on interval analysis is established. This model also considers the dimension tolerance of design variables, and it uses symmetric tolerance to describe the uncertainty of design variables. The interval order relation and possibility degree of interval number are employed to deal with the uncertainty of objective function and constraint condition, respectively. On this basis, a multiobjective robust optimization model in view of interval analysis is established and applied to the robust optimization of the EMU brake module.FindingsCompared with the traditional method and the method proposed in the reference, the maximum stress fluctuation of the EMU brake module structure is smaller after using the method proposed in this paper, which indicates that the robustness of the maximum stress of the structure has been improved. In addition, the weight and strength of the structure meet the design requirements. It shows that this method and model introduced in this research have certain feasibility.Originality/valueThis study is the first attempt to apply the robust optimization model based on interval analysis to the optimization of EMU structure and obtain the optimal solution set that meets the design requirements. Therefore, this study provides an idea for nonprobabilistic robust optimization of the EMU structure.
Metabolomic analyses on microbial primary and secondary oxidative stress responses
Authors: Pan Yuanyuan , Cheng Jun‐Hu , Sun Da‐Wen 
Published: October 2021

AbstractFood safety is veryimportant in our daily life. In food processing or disinfection, microorganisms are commonly exposed to oxidative stress perturbations. However, microorganisms can adapt and respond to physicochemical interventions, leading to difficulty and complexity for food safety assurance. Therefore, understanding the response mechanisms of microbes and providing an overview of the responses under oxidative stress conditions are beneficial for ensuring food safety for the industry. The current review takes the metabolomics approach to reveal small metabolite signatures and key pathway alterations during oxidative stress at the molecular and technical levels. These alterations are involved in primary oxidative stress responses due to inactivation treatments such as using hypochlorite (HOCl), hydrogen peroxide (H2O2), electrolyzed water (EW), irradiation, pulsed light (PL), electron beam (EB), and secondary oxidative stress responses due to exposures to excessive conditions such as heat, pressure, acid, and alkaline. Details on the putative origin of exogenous or endogenous reactive oxygen species (ROS) are discussed, with particular attention paid to their effects on lipid, amino acid, nucleotide, and carbohydrate metabolism. In addition, mechanisms on counteracting oxidative stresses, stabilization of cell osmolality as well as energy provision for microbes to survive are also discussed.
Estimating the time since admixture from phased and unphased molecular data
Authors: Janzen Thijs , Miró Pina Verónica 
Published: October 2021

AbstractAfter admixture, recombination breaks down genomic blocks of contiguous ancestry. The breakdown of these blocks forms a new “molecular clock” that ticks at a much faster rate than the mutation clock, enabling accurate dating of admixture events in the recent past. However, existing theory on the breakdown of these blocks, or the accumulation of delineations between blocks, so‐called “junctions”, has mostly been limited to using regularly spaced markers on phased data. Here, we present an extension to the theory of junctions using the ancestral recombination graph that describes the expected number of junctions for any distribution of markers along the genome. Furthermore, we provide a new framework to infer the time since admixture using unphased data. We demonstrate both the phased and unphased methods on simulated data and show that our new extensions have improved accuracy with respect to previous methods, especially for smaller population sizes and more ancient admixture times. Lastly, we demonstrate the applicability of our method on three empirical data sets, including labcrosses of yeast (Saccharomyces cerevisae) and two case studies of hybridization in swordtail fish and Populus trees.
Prognostic implication of erector spinae muscles in non‐small‐cell lung cancer patients treated with immuno‐oncology combinatorial chemotherapy
Authors: Araki Taisuke , Kitaguchi Yoshiaki , Suzuki Yusuke , Komatsu Masamichi , Sonehara Kei , Wada Yosuke , Tateishi Kazunari , Hanaoka Masayuki 
Published: October 2021

AbstractBackgroundThe quantity of skeletal muscles has recently been reported to have prognostic value in patients with non‐small‐cell lung cancer (NSCLC) treated with second‐line immunotherapy. However, the prognostic role of skeletal muscle assessment in NSCLC patients undergoing first‐line immuno‐oncology (IO) combinatorial treatment (IO‐chemotherapy) has not been elucidated.MethodsWe retrospectively reviewed 36 patients with NSCLC undergoing first‐line IO‐chemotherapy between April 2018 and June 2021 in our hospital. The cross‐sectional area of the erector spinae muscle (ESMCSA) was evaluated by manual tracing on computed tomography scans at the level of the 12th thoracic vertebra before initiating IO‐chemotherapy. To minimize deviation due to physique, the ESMCSA was adjusted by body surface area (BSA) (ESMCSA to BSA ratio: ESMCSA/BSA). A survival time analysis was performed using the Kaplan–Meier method and log‐rank test. A multivariate analysis with Cox proportional hazards model was conducted to investigate the prognostic value of the ESMCSA/BSA and inflammatory and nutritional indices.ResultsThe median progression‐free survival (PFS) and overall survival (OS) were 6.5 and 16.6 months, respectively. Intergroup comparison by the log‐rank test revealed that there was no significant difference in the median PFS, but the median OS was significantly long in the high ESMCSA/BSA (>19 cm2/m2) (high ESMCSA/BSA group, p = 0.0373). The multivariate analysis showed that ESMCSA/BSA was an independent prognostic factor for OS (hazard ratio 0.79, p = 0.044).ConclusionsThe results of this study indicate that the pretreatment ESMCSA/BSA may be a potential prognostic factor in NSCLC patients receiving first‐line IO‐chemotherapy.
Unfinished business: Functional outcomes in a randomized controlled trial of a three‐year extension of early intervention versus regular care following two years of early intervention for psychosis
Authors: Mustafa Sally S. , Malla Ashok , Joober Ridha , Abadi Sherezad , Latimer Eric , Schmitz Norbert , Jarvis G. Eric , Margolese Howard C. , Casacalenda Nicola , Abdel‐Baki Amal , Iyer Srividya N. 
Published: October 2021

AbstractObjectiveTo investigate whether first‐episode psychosis patients receiving extended early intervention had better functional outcomes than those in regular care and to examine the predictors of functional outcomes.MethodsThis is a randomized controlled single‐blind trial of 220 patients randomized after 2 years of early intervention to receive early intervention or regular care for the subsequent 3 years. Outcomes included cumulative time in functional recovery during the 3‐year trial assessed using the Social and Occupational Functioning Assessment Scale (SOFAS); and employment/education at last assessment which were, respectively, analyzed using multiple linear regression and logistic regression, accounting for well‐known predictors. Linear mixed and generalized linear models were also used to examine the course of SOFAS and employment/education over the 3‐year period.ResultsThe extended early intervention and regular care groups did not differ on time in functional recovery (mean = 50.17 weeks, SD = 46.62 vs. mean = 46.18 weeks, SD = 51.54); percent employed/in school (60.4% vs. 68.8%) or change in SOFAS or employment/education status over time. SOFAS scores were stable between years 2 and 5. Individuals with longer periods of total symptom remission experienced significantly longer periods of functional recovery and were likelier to be employed/in school. Those who had completed high school were nine times likelier to be employed/studying.ConclusionMost individuals maintained functional gains accrued from 2 years of early intervention with no further improvement whether in extended early intervention or regular care. There was a gap between symptomatic and functional recovery, and one‐third were unemployed/not in school at year 5. The lack of additional progress even in extended early intervention suggests that specific interventions addressing functional roles need to be provided beyond the first 2 years of early intervention. Sustaining symptom remission and high‐school completion may be additional avenues for targeting functional recovery.
Individual moral responsibility for antibiotic resistance
Authors: Ancillotti Mirko , Nihlén Fahlquist Jessica , Eriksson Stefan 
Published: October 2021

AbstractAntibiotic resistance (AR) is a major threat to public health and healthcare worldwide. In this article, we analyse and discuss the claim that taking actions to minimize AR is everyone's responsibility, focusing on individual moral responsibility. This should not be merely interpreted as a function of knowledge of AR and the proper use of antibiotics. Instead, we suggest a circumstantial account of individual responsibility for AR, where individuals do or do not engage in judicious antibiotic behaviour with different degrees of voluntariness. Furthermore, we suggest a notion of responsibility as a virtue, in which individuals have the opportunity to develop a sensitivity towards the AR theme and, consequently, are capable of engaging, actively and voluntarily, in judicious antibiotic behaviour. The development of such sensitivity depends on the creation of adequate circumstances, that is individual capacities and availability of resources.
Effects of sevelamer carbonate versus calcium acetate on vascular calcification, inflammation, and endothelial dysfunction in chronic kidney disease
Authors: Mason Darius L. , Godugu Kavitha , Nnani Daryl , Mousa Shaker A. 
Published: October 2021

AbstractHyperphosphatemia is present in most patients with end‐stage renal disease (ESRD) and has been associated with increased cardiovascular mortality. Phosphate binders (calcium‐based and calcium free) are the mainstay pharmacologic treatment to lower phosphorus levels in patients with ESRD. We evaluated biochemical markers of vascular calcification, inflammation, and endothelial dysfunction in patients with chronic kidney disease (CKD) treated with sevelamer carbonate (SC) versus calcium acetate (CA). Fifty patients with CKD (stages 3 and 4) were enrolled and assigned to treatment with SC and CA for 12 weeks. At the end of the study the biomarkers of vascular calcification, inflammation, and endothelial dysfunction were analyzed. A significant increase in HDL‐cholesterol was observed with SC but not with CA in patients with CKD. Treatment with SC reduced serum phosphate, calcium phosphate, and FGF‐23 levels and there was no change with CA treatment. The inflammatory markers IL‐8, IFN‐γ, and TNFα decreased with response to both treatments. The levels of IL‐6 significantly increased with CA treatment and no change was observed in the SC treatment group. SC showed favorable effects on anti‐inflammatory and vascular calcification biomarkers compared to CA treatment in patients with CKD stages 3 and 4 with normal phosphorous values.
Androgen insensitivity syndrome: Can cytology help?
Authors: Dahiya Sakshi , Singh Meeta , Mandal Shramana , Jain Shyam Lata , Rathore Asmita , Lal Pawanindra 
Published: October 2021

AbstractAndrogen insensitivity syndrome (AIS) is described as a patient's clinical (phenotypical) presentation as a female with male karyotyping. Classically, patients are normal looking females with complaints of primary amenorrhea. The gonads may be found as extra‐genital swellings; rarely, the testes may undergo malignant transformation. Thus, gonadectomy is indicated in these patients on attaining puberty. A rare and interesting case of clinically unsuspected AIS in a young female who presented with primary amenorrhea and inguinal swelling is reported. The initial diagnosis was suggested on fine needle aspiration cytology (FNAC) from the inguinal swelling that showed the presence of Sertoli cells. Further family history revealed two similar siblings; karyotyping and histopathology confirmed the diagnosis of AIS in the patient. This case highlights the importance of FNAC in early diagnosis and a multidisciplinary approach to confirm the diagnosis and help in appropriate management.
Prevalence and factors associated with chronic venous insufficiency, leg ulceration and deep‐vein thrombosis among people who inject drugs in London, UK
Authors: Doran Jason , Hope Vivian , Wright Talen , Scott Jenny , Ciccarone Daniel , Harris Magdalena 
Published: October 2021

AbstractIntroductionPeople who inject drugs (PWID) are vulnerable to a range of harms, including vascular conditions such as chronic venous insufficiency (CVI), leg ulcers and deep vein thrombosis (DVT). The extent of vascular conditions has rarely been studied, despite contributing to considerable illness and disability among PWID. We assess the prevalence and associations of vascular conditions in PWID in London, UK.MethodsSurvey data from the community‐recruited Care and Prevent Study of PWID in London were analysed. Participants were asked about CVI and leg ulcers using pictorial questions, and if they had ever been diagnosed with DVT. Associations between vascular conditions and demographic/drug‐use information were explored using univariate and multivariable logistic regression.ResultsAmong participants (n = 455), the prevalence of CVI, leg ulcers and DVT was 13% (n = 57), 10% (n = 46) and 23% (n = 105), respectively. CVI and DVT were positively associated with injecting into the groin, while injecting into the leg was positively associated with leg ulcers and DVT. CVI was also associated with not cleaning injection sites and diagnosed hepatitis C virus, and DVT with hepatitis C virus.Discussion and ConclusionThe prevalence of vascular problems among PWID in London is very high in comparison to the general population. These conditions are primarily associated with injection into the femoral vein. Use of these injection sites indicates peripheral venous access problems. There is a need to reinvigorate safe injection information provision in harm reduction services, with attention to reducing risk practices associated with venous damage and transitions to femoral injection.