bluuebunny/crossref_metadata_2025_split huggingface dataset:
GPS tracking reveals landfill closures induce higher foraging effort and habitat switching in gulls
Authors: Langley Liam P. , Bearhop Stuart , Burton Niall H.K. , Banks Alex N. , Frayling Tim , Thaxter Chris B. , Clewley Gary D. , Scragg Emily , Votier Stephen C. 
Published: November 2021

Abstract
Background
Landfills are a major subsidy for some animals, with implications for their life history and demography. Gulls feed extensively on food from landfills and closures are expected to have ecological consequences, but how this influences movement ecology is virtually unknown.

Methods
We used GPS-tracking to quantify foraging behaviour and habitat choice of lesser black-backed gulls (Larus fuscus) breeding at two colonies before and after closure of two nearby landfills.

Results
Following closure, gulls from both colonies travelled further and for longer to forage. Gulls also changed habitat selection, although this differed by colony - birds from one colony shifted to agricultural habitats, while at the other, increased their use of urban areas. These behavioural responses had no effect on adult body condition but hint at potential direct effects of higher foraging costs and indirect impacts by shifting to new habitats.

Conclusions
Our results demonstrate how landfill availability influences gull foraging movements and habitat selection. We also emphasize the value of biologging to detect rapid behavioural responses in contrast to more conventional demographic approaches, which is especially important for animals that spend the majority of their lives away from direct observation.
Tyrosine 136 phosphorylation of α-synuclein aggregates in the Lewy body dementia brain: involvement of serine 129 phosphorylation by casein kinase 2
Authors: Sano Kazunori , Iwasaki Yasushi , Yamashita Yuta , Irie Keiichi , Hosokawa Masato , Satoh Katsuya , Mishima Kenichi 
Published: November 2021

AbstractSerine 129 (S129) phosphorylation of α-synuclein (αSyn) is a central feature of Lewy body (LB) disease pathology. Although the neighboring tyrosine residues Y125, Y133, and Y136 are also phosphorylation sites, little is known regarding potential roles of phosphorylation cross-talk between these sites and its involvement in the pathogenesis of LB disease. Here, we found that αSyn aggregates are predominantly phosphorylated at Y136 in the Lewy body dementia brain, which is mediated by unexpected kinase activity of Casein kinase 2 (CK2). Aggregate formation with S129 and Y136 phosphorylation of recombinant αSyn (r-αSyn) were induced by CK2 but abolished by replacement of S129 with alanine (S129A) in vitro. Mutation of Y136 to alanine (Y136A) promoted aggregate formation and S129 phosphorylation of r-αSyn by CK2 in vitro. Introduction of Y136A r-αSyn oligomers into cultured cells exhibited increased levels of aggregates with S129 phosphorylation compared to wild-type r-αSyn oligomers. In addition, aggregate formation with S129 phosphorylation induced by introduction of wild-type r-αSyn oligomers was significantly attenuated by CK2 inhibition, which resulted in an unexpected increase in Y136 phosphorylation in cultured cells. Our findings suggest the involvement of CK2-related αSyn Y136 phosphorylation in the pathogenesis of LB disease and its potential as a therapeutic target.
Nudging sugar portions: a real-world experiment
Authors: Villinger Karoline , Wahl Deborah R. , Engel Kai , Renner Britta 
Published: November 2021

Abstract
Background
Sugar overconsumption is a major contributor to overweight and obesity, with daily consumption greatly exceeding the WHO’s recommendations. The aim of the present study was to determine whether using a functionally modified sugar shaker as a food environment nudge could be an effective means to reduce the sugar used in hot beverages.

Methods
Sugar shakers were functionally modified to reduce the amount of sugar in each pour by 47%. A real-world experiment was conducted to compare the amount of added sugar per hot beverage during default and nudge conditions over the course of four weeks (17,233 hot beverages sold) in a university take-away café. In addition, 59 customers were surveyed to evaluate the acceptance of the intervention.

Results
Modifying the functional design of sugar shakers resulted in a reduction of added sugar by 20% (d = 1.35) compared to the default condition. In the survey, most participants evaluated the intervention strategy positively.

Conclusion
The present real-world experiment demonstrates that a simple environmental intervention can significantly reduce sugar consumption in public places while meeting with consumer approval, making it a promising means of reducing sugar overconsumption.
Evaluation of a health education program for improving uptake of HIV self-testing by men in Rwanda: a pilot pragmatic randomized control trial
Authors: Dzinamarira Tafadzwa , Muvunyi Claude Mambo , Mashamba-Thompson Tivani Phosa 
Published: November 2021

Abstract
Background
Health education interventions tailored to suit men have the potential to improve health outcomes for this underserved population. HIV self-testing (HIVST) is a promising approach to overcoming challenges associated with low HIV testing rates among men. The primary objective of this study is to assess the feasibility of conducting a definitive trial to determine the effectiveness of a locally adapted and optimized health education program (HEP) on the uptake of HIVST among men in Kigali, Rwanda.

Methods
This study employs a pilot pragmatic randomized controlled trial to evaluate an HIVST HEP for men. Participants were randomized to the intervention (HEP) arm or to the control arm. In the intervention group, the adapted HEP was administered in addition to routine health education. In the non-intervention group, only routine health education was offered. Participant data was collected first upon recruitment and then after 3 months’ follow-up using interviewer-administered questionnaires.

Results
There was a 100% response rate at enrollment and no loss to follow-up at exit. There was significant association between the study arm and knowledge of HIVST. Participants in the control arm had a mean knowledge score of 67% compared to 92% among participants in the intervention arm. There was an association between the study arm and HIVST uptake: 67% of the study participants in the intervention arm self-reported HIVST uptake compared to 23% of the participants in the control arm.

Discussion
This pilot study demonstrates the feasibility of a larger trial to assess the effectiveness of an HEP intervention on uptake of HIVST among men. We found preliminary evidence of increased uptake of HIVST in the intervention group.

Trial registration
Pan African Clinical Trial Registry PACTR201908758321490. Registered on 8 August 2019.
Advances in the development of hemostatic biomaterials for medical application
Authors: Sung Yong Kiel , Lee Dae Ryeong , Chung Dong June 
Published: November 2021

Abstract

Background
Medical hemostatic biological materials are necessary for the development of the process of preventing and stopping damaged intravascular bleeding. In the process, some red blood cells and white blood cells are trapped in nets. The resulting plug is called a blood clot. This is often a good step in wound healing, but separation of blood clots from blood vessel walls can cause serious health problems.

Main body

The advance in the development of hemostatic biomaterials is necessary for biomedical application. Firstly, the historical background of artificial hemostasis has been included and the current research of hemostasis has been included in more detail. Secondly, the current research of hemostasis has been included on the oxidized cellulose-based hemostatic biomaterials such as starch based on composite cross-linking hemostatic networks, hemostatic materials on
N
HS-esters, hemostatic agent from local materials and biomaterials for hemostatic management. Thirdly, polysaccharide hemostatic materials, bio-inspired adhesive catechol-conjugated chitosan, mesoporous silica and bioactive glasses for improved hemostasis, minimally invasive hemostatic biomaterials and chitosan-base materials for hemostatic application have been included. Fourthly, the biological properties of natural hemostatic agent by plasma technology and the hemostatic agents based on gelatin-microbial transglutaminase mixes have been also included.

Conclusion
Current research on hemostasis includes hemostatic biomaterials such as cellulose-based hemostatic starch based on a complex cross-linked hemostatic network. It also includes polysaccharide hemostatic materials, biomimetic adhesive catechol-binding chitosan, mesoporous silica or physiologically active glass for hemostatic improvement, minimally invasive hemostatic chitosan-based materials, and gelatin-microbial transglutaminase-based hemostatic agents. Future studies should focus on modular combination of hemostatic imitation and reinforcement mechanisms of different materials and technologies to find the optimal system to promote and strengthen active platelet or platelet imitation aggregation in bleeding sites. The second optionally increases the production of thrombin and fiber formation at the site. Third, the formed fibrin biopolymer network has strengthened to reduce thrombosis and amplify hemostasis.
Antimutagenic, anti-inflammatory, and antioxidative activities of the juice of Vitis ficifolia var. Ganebu, a woody vine in the grape family, known as Ryukyu-ganebu in Japan
Authors: Arimoto-Kobayashi Sakae , Hida Ryoko , Fujii Nana , Mochioka Ryosuke 
Published: November 2021

Abstract
Background
Mutation, inflammation, and oxidative damage including lipid-peroxidation are factors involved in the development of cancer. We investigated the antimutagenic, in vivo and in vitro anti-inflammatory, and antioxidative effects of the juice of Vitis ficifolia var. ganebu (known as Ryukyu-ganebu in Japan) harvested in Kuchinoshima island (hereafter, the juice is referred to as ganebu-K) in comparison with the juice of Vitis coignetiae (crimson glory vine, known as yamabudo in Japan; hereafter, the juice is referred to as yamabudo) which we found antimutagenic and anti-inflammatory effects.

Results
Ganebu-K inhibited the mutagenic activity of several carcinogens, MeIQx, IQ, Trp-P-2(NHOH), and MNNG, model compounds of tumor initiation. Using S. typhimurium YG7108, a strain lacking O6-methylguanine DNA methyltransferases, ganebu-K showed no significant inhibition of the mutagenicity of MNNG. Thus, DNA repair of O6-methylguanine produced by MNNG might be an antimutagenic target of the components in ganebu-K. Topical application of ganebu-K to the dorsal sides of mice resulted in potent suppression of acute edema induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Ganebu-K, but not yamabudo, exhibited significant inhibition of the induction of prostaglandin E2 (PGE2) induced by TPA. Components contained in ganebu-K, but not in yamabudo, might be responsible for the inhibition of the induction of PGE2. Ganebu-K inhibited in vivo lipid peroxidation and decreased the level of glutamic oxaloacetic transaminase induced by CCL4 treatment.

Conclusions
These results suggest that the active components in ganebu-K juice are not the same as those in yamabudo, and the components in ganebu-K are attractive candidates as chemopreventive agents.
Area postrema syndrome in neuromyelitis optica spectrum disorder: diagnostic challenges and descriptive patterns
Authors: Khedr Eman M. , Farweez Hassan M. , Abo Elfetoh Noha , Badawy Eman R. , Hassanein Sara , Mahmoud Doaa M. , Nasreldein Ahmed 
Published: November 2021

AbstractBackgroundAlthough area postrema syndrome (APS) is one of the core clinical features of neuromyelitis optic spectrum disorder (NMOSD), it is frequently misdiagnosed as gastrointestinal or systemic disorders. In this study, we describe the diagnostic challenges in NMOSD patients with APS and their characteristic clinical and radiological features. All patients who attended our university hospitals during the period from March 2019 to August 2020 with a diagnosis of NMOSD according to the latest diagnostic criteria were admitted and evaluated clinically, radiologically with gadolinium-enhanced brain and spinal MRI, measures of serum Anti-Aquaporin 4 (Anti-AQP4) and clinical status using the Expanded Disability Status Scale (EDSS) scores. APS was diagnosed if there was a history of intractable nausea, vomiting, or hiccups (INVH) that had lasted longer than 1 week with the exclusion of other etiologies, or less than 48 h if associated with a lesion in the dorsal medulla on MRI scan.ResultsTwenty out of 90 (22.2%) identified patients with a diagnosis of NMOSD had a history of unexplained intractable nausea, vomiting or hiccoughs lasting an average of 20 days. Seventeen patients were anti-Aquaporin 4 seropositive. Seven patients (35%) presented initially with isolated clinical features of APS and were diagnosed only after subsequent relapse. Patients with APS preceding other core clinical presentations (13 cases, 65%) were diagnosed after development of motor manifestations. All patients developed acute myelitis during the course of illness. Brain and spinal MRI scans showed that 13 had a linear lesion in the dorsal tegmentum of the medulla oblongata adjacent to the fourth ventricle. Otherwise, longitudinally extensive transverse myelitis was found in 80%, while 35% showed extension of the cord lesion to the AP.ConclusionsAPS as a core clinical characteristic of NMOSD is not a rare presentation as was previously thought and can occur in both AQP4-seropositive and seronegative NMOSD.
Multimineral petrophysics of thermally immature Eagle Ford Group and Cretaceous mudstones, U.S. Geological Survey Gulf Coast 1 research wellbore in central Texas
Authors: Burke Lauri A. , Birdwell Justin E. , Paxton Stanley T. 
Published: November 2021

Traditional petrophysical methods to evaluate organic richness and mineralogy using gamma-ray and resistivity log responses are not diagnostic in source rocks. We have developed a deterministic, nonproprietary method to quantify formation variability in total organic carbon (TOC) and three key mudrock mineralogical components of nonhydrocarbon-bearing source rock strata of the Eagle Ford Group by developing a set of log-derived multimineral models calibrated with Fourier transform infrared spectroscopy core data from the research borehole U.S. Geological Survey Gulf Coast 1 West Woodway. We determined that bulk density response is a reliable indicator of organic content in these thermally immature, water-bearing source rocks. Multimineral findings indicate that a high degree of laminae-scale mineralogical heterogeneity exists due to thinly interbedded carbonate cements amid clay-rich mudstone layers. The lower part of the Eagle Ford Group contains the highest average TOC content (4.7 wt%) and the highest average carbonate volume (64.1 vol%), making it the optimal target in thermally mature areas for source-rock potential and hydraulic-fracture placement. In contrast, the uppermost portion of the Eagle Ford Group contains the highest average volume of clay minerals (42.6 vol%), which increases the potential for wellbore stability issues. Petrophysical characterization reveals that porosity is approximately 30% in this relatively uncompacted formation. In this thermally immature source rock, water saturation is nearly 100% and no free hydrocarbons were observed on the resistivity logs. No evidence of borehole ellipticity was observed on the three-arm caliper log, and horizontal stresses are presumed to be directionally uniform in the vicinity of this near-surface wellbore. This shallow wellbore has a temperature gradient of 1.87°F/100 ft (16.3°C/km) and is likely influenced by earth surface heating.
Frequency of success and complications of primary endoscopic third ventriculostomy in infants with obstructive hydrocephalous
Authors: Sharafat Seema , Khan Zahid , Azam Farooq , Ali Mumtaz 
Published: November 2021

Objectives: To determine the success rate and complications of primary endoscopic third ventri-culostomy (ETV) in infants with obstructive hydrocephalous.
Methods: This case series was conducted at the Department of Neurosurgery, Medical and Teaching Institute, Lady Reading Hospital Peshawar from July 2016 to June 2018. All consecutive patients with age less than one year who underwent ETV for primary obstructive hydrocephalous, of both gender, were included in the study. The patients were followed up to six months after surgery. The data was entered in a specially designed Performa. Patients’ data was analyzed using SPSS version 21.0.
Results: We had total 21 patients with age less than one year during the study period. Male patients were 11 (52.4%). Success rate of ETV at six months of follow up was 12 (57.1%). Post-op complications observed were in 9.52% (2/21) cases. One patient had cerebrospinal fluid CSF) leak and the other had significant bleed.
Conclusion: ETV is successful in 57.1% of infants with obstructive type of hydrocephalous. The post op complications in case of ETV are lower than Ventriculo-peritoneal shunts. Therefore, ETV can be offered to infants having obstructive hydrocephalous.
doi: https://doi.org/10.12669/pjms.38.1.4097
How to cite this:Sharafat S, Khan Z, Azam F, Ali M. Frequency of success and complications of primary endoscopic third ventriculostomy in infants with obstructive hydrocephalous. Pak J Med Sci. 2022;38(1):267-270. doi: https://doi.org/10.12669/pjms.38.1.4097
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Electrosurgical bipolar vessel sealing versus conventional clamping and suturing for total abdominal hysterectomy
Authors: Ulubay Mustafa , Kıncı Mehmet Ferdi , Pay Ramazan Erda , Dede Murat 
Published: November 2021

Objectives: To compare the use of Electrosurgical bipolar vessel sealing LigaSure™ small jaw instrument (LSJI) with conventional suture ligation in total abdominal hysterectomy (TAH).
Methods: In this retrospective study 80 patients who underwent hysterectomy in the Gynecology and Obstetrics Department of Gulhane Education and Research Hospital between April 2017 and August 2018 were included. Two different groups that underwent Electrosurgical bipolar vessel sealing LigaSure™ small jaw instrument (LSJI) and conventional suture ligation in hysterectomy operation were analyzed retrospectively. The parameters evaluated and compared between the two groups include operation time, intraoperative blood loss, duration of hospitalization and incision length.
Results: Among the parameters we compared between the two groups, there was no statistically significant difference between the amount of intraoperative blood loss (p:0.68) and the incision length (p:0.65). Among the parameters we compared between the two groups, a statistically significant difference was observed between the operation time (p:0.016) and the duration of hospitalization (p:0.01).
Conclusion: Our comparison of LSJI vs. conventional ligation in hysterectomy revealed a significant difference only in operative time, where surgeries involving conventional ligation were shorter. On the other hand, incision length was evaluated in our study which has not been addressed in previous studies. There is also a need for multi-center studies that include more patients and evaluate cost-effectiveness.
doi: https://doi.org/10.12669/pjms.38.1.4197
How to cite this:Ulubay M, Kinci MF, Pay RE, Dede M. Electrosurgical bipolar vessel sealing versus conventional clamping and suturing for total abdominal hysterectomy. Pak J Med Sci. 2022;38(1):156-161. doi: https://doi.org/10.12669/pjms.38.1.4197
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
An insightful estimation of undergraduate medical students’ experience about the Flipped Classroom
Authors: Abdulghani Hamza Mohammad , Sattar Kamran , Ahmad Tauseef , Halepoto Dost Muhammad , Akram Ashfaq 
Published: November 2021

Background and Objective: The Flipped Classroom (FC) approach has become increasingly predominant and popular in medical education. This study aimed to explore the usefulness and the scope of FC based on medical students’ experience, with their adaptation challenges.
Methods: The present study was a mixed-method accomplished during the academic years 2019-20, involving fourth-year students at the College of Medicine in Riyadh, Saudi Arabia. A self-administered questionnaire was used to seek their first experience and opinion of the FC.
Results: A total of 234 questionnaires were distributed to the students, and 214 students completed the survey (response rate of 91.45%). Out of this total, 68.2 % were males and 31.8% were females. Most of the students agreed 156 (72.9%) that the flipped classroom was more engaging than the traditional lecture, among them 100 (68.5%) males and 56 (82.3) females agreed. Almost ~79% of students liked FC as it enabled them knowing the material in advance, and the class time was spent clarifying the facts and principles with active interaction, as commented during focus group discussion “More chance for discussing with the doctors, and I got the chance to answer” (St. 6).
Conclusion: The results showed that the students like the FC more than the conventional classroom. Suggestions were given by students to improve the active learning sessions within the FC modality.
doi: https://doi.org/10.12669/pjms.38.1.4256
How to cite this:Abdulghani HM, Sattar K, Ahmad T, Halepoto DM, Akram A. An insightful estimation of undergraduate medical students’ experience about the Flipped Classroom. Pak J Med Sci. 2022;38(1):69-75. doi: https://doi.org/10.12669/pjms.38.1.4256
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.