bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mass spectrometry analysis of human tear fluid biomarkers specific for ocular and systemic diseases in the context of 3P medicine
Authors: Zhan Xianquan , Li Jiajia , Guo Yuna , Golubnitschaja Olga 
Published: December 2021

AbstractOver the last two decades, a large number of non-communicable/chronic disorders reached an epidemic level on a global scale such as diabetes mellitus type 2, cardio-vascular disease, several types of malignancies, neurological and eye pathologies—all exerted system’s enormous socio-economic burden to primary, secondary, and tertiary healthcare. The paradigm change from reactive to predictive, preventive, and personalized medicine (3PM/PPPM) has been declared as an essential transformation of the overall healthcare approach to benefit the patient and society at large. To this end, specific biomarker panels are instrumental for a cost-effective predictive approach of individualized prevention and treatments tailored to the person. The source of biomarkers is crucial for specificity and reliability of diagnostic tests and treatment targets. Furthermore, any diagnostic approach preferentially should be noninvasive to increase availability of the biomaterial, and to decrease risks of potential complications as well as concomitant costs. These requirements are clearly fulfilled by tear fluid, which represents a precious source of biomarker panels. The well-justified principle of a “sick eye in a sick body” makes comprehensive tear fluid biomarker profiling highly relevant not only for diagnostics of eye pathologies but also for prediction, prognosis, and treatment monitoring of systemic diseases. One prominent example is the Sicca syndrome linked to a cascade of severe complications that include dry eye, neurologic, and oncologic diseases. In this review, protein profiles in tear fluid are highlighted and corresponding biomarkers are exemplified for several relevant pathologies, including dry eye disease, diabetic retinopathy, cancers, and neurological disorders. Corresponding analytical approaches such as sample pre-processing, differential proteomics, electrophoretic techniques, high-performance liquid chromatography (HPLC), enzyme-linked immuno-sorbent assay (ELISA), microarrays, and mass spectrometry (MS) methodology are detailed. Consequently, we proposed the overall strategies based on the tear fluid biomarkers application for 3P medicine practice. In the context of 3P medicine, tear fluid analytical pathways are considered to predict disease development, to target preventive measures, and to create treatment algorithms tailored to individual patient profiles.
Psychosocial Risk Factors for Overuse Injuries in Competitive Athletes: A Mixed-Studies Systematic Review
Authors: Tranaeus Ulrika , Martin Simon , Ivarsson Andreas 
Published: December 2021

AbstractBackgroundWhile the psychosocial risk factors for traumatic injuries have been comprehensively investigated, less is known about psychosocial factors predisposing athletes to overuse injuries.ObjectiveThe aim of this review was to systematically identify studies and synthesise data that examined psychosocial risk factors for overuse injuries in athletes.DesignSystematic review.Data SourcesMEDLINE, Web of Science and PsycINFO databases, supplemented by hand searching of journals and reference lists.Eligibility Criteria for Selecting StudiesQuantitative and qualitative studies involving competitive athletes, published prior to July 2021, and reporting the relationship between psychosocial variables and overuse injury as an outcome were reviewed. This was limited to academic peer-reviewed journals in Swedish, English, German, Spanish and French. An assessment of the risk of bias was performed using modified versions of the RoBANS and SBU Quality Assessment Scale for Qualitative Studies.ResultsNine quantitative and five qualitative studies evaluating 1061 athletes and 27 psychosocial factors were included for review. Intra-personal factors, inter-personal factors and sociocultural factors were found to be related to the risk of overuse injury when synthesised and reported according to a narrative synthesis approach. Importantly, these psychosocial factors, and the potential mechanisms describing how they might contribute to overuse injury development, appeared to be different compared with those already known for traumatic injuries.ConclusionsThere is preliminary evidence that overuse injuries are likely to partially result from complex interactions between psychosocial factors. Coaches and supporting staff are encouraged to acknowledge the similarities and differences between traumatic and overuse injury aetiology.
A Preference for Peers over Faculty in the Pandemic Era: Development and Evaluation of a Medical Student-led Virtual Physiology Exam Review
Authors: Alexeeva Arina , Archibald Abigail R. , Breuer Joseph A. , Greenberg Milton L. 
Published: December 2021

AbstractIn the middle of the COVID-19 pandemic, students at the University of California, Irvine, reimagined their peer-led, small-group, tutorial sessions into an online format. The virtual sessions improved student-reported understanding of physiological principles and reduced exam anxiety. Peer-led review remains a valuable resource in the era of virtual medical education.
Agronomic Biofortification with Se, Zn, and Fe: An Effective Strategy to Enhance Crop Nutritional Quality and Stress Defense—A Review
Authors: Szerement Justyna , Szatanik-Kloc Alicja , Mokrzycki Jakub , Mierzwa-Hersztek Monika 
Published: December 2021

AbstractHuman micronutrient deficiencies are a widespread problem worldwide and mainly concern people whose diet (mainly of plant origin) consists of insufficient amounts of critical vitamins and minerals. Low levels of micronutrients in plants are linked to, i.e., their decreasing concentration in soils and/or low bioavailability and presence of abiotic stresses which disturb the proper growth and development of plants. Agronomic biofortification of crops is a very promising way to improve the concentration of micronutrients in edible parts of crops without compromising yield and is recognized as the cheapest strategy to alleviate hidden hunger worldwide. The review is focused on the factors influencing the effectiveness of biofortified crops (a type of application, form, and a dose of applied microelement, biofertilizers, and nanofertilizers). Also, the accumulation of zinc, selenium, and iron in edible parts of crops, their effects on metabolism, morphological and yield parameters, and an impact on plants’ defense mechanisms against abiotic stress like salt, high/low temperature, heavy metal, and drought was discussed. Finally, the directions of future agronomic biofortification studies are proposed.
INVARIANCE CRITERIA AS META-CONSTRAINTS
Authors: SAGI GIL 
Published: December 2021

AbstractInvariance criteria are widely accepted as a means to demarcate the logical vocabulary of a language. In previous work, I proposed a framework of “semantic constraints” for model-theoretic consequence which does not rely on a strict distinction between logical and nonlogical terms, but rather on a range of constraints on models restricting the interpretations of terms in the language in different ways. In this paper I show how invariance criteria can be generalized so as to apply to semantic constraints on models. Some obviously unpalatable semantic constraints turn out to be invariant under isomorphisms. I shall connect the discussion to known counter-examples to invariance criteria for logical terms, and so the generalization will also shed light on the current existing debate on logicality. I analyse the failure of invariance to fulfil its role as a criterion for logicality, and argue that invariance conditions should best be thought of as merely methodological meta-constraints restricting the ways the model-theoretic apparatus should be used.
Noxious weed views and behaviors in Montana after 25 years of public education
Authors: Mangold Jane M. , Frame-Martin Shantell A. , Raile Eric D. 
Published: December 2021

AbstractIn 1994, a general population survey was conducted to evaluate Montanans’ knowledge about noxious weeds, and results from that survey launched an ongoing statewide education campaign. In 2019, we conducted another general population survey to assess the views and behaviors of Montanans as they relate to noxious weeds and to identify new approaches for disseminating noxious weed information. We also asked questions to evaluate changes over the 25-yr period, although our ability to make direct comparisons is subject to limitations. We implemented a mail-based survey in March through May 2019. The response rate was 18%, with 830 responses from 4,582 valid mailing addresses. Just under half (48%) of respondents report “little” or “no” knowledge about noxious weeds, which would constitute a 19-point improvement since 1994. A large majority (68%) of respondents indicate that noxious weeds are a “serious” or “very serious” problem, and appreciation for the range of negative impacts associated with noxious weeds is considerable. Most respondents (61%) identify humans as contributing “a lot” to noxious weed spread, and respondents report that their behaviors to prevent the spread of noxious weeds have increased over time. While the 1994 respondents rated television, newspaper, and radio as the best ways to disseminate information about noxious weeds, respondents now also recognize methods such as websites and social media pages as effective. Our survey identifies a need for increased educational messaging for women and people in the 18 to 39 age group. Overall, our results indicate that individuals who have seen different forms of advertisements and have participated in educational programs are more likely to consider noxious weeds a serious problem and to engage in behaviors to stop their spread.
DENDROCHRONOLOGY AND RADIOCARBON DATING
Authors: Pearson Charlotte L , Leavitt Steven W , Kromer Bernd , Solanki Sami K , Usoskin Ilya 
Published: December 2021

ABSTRACTBoth dendrochronology and radiocarbon (14C) dating have their roots back in the early to mid-1900s. Although they were independently developed, they began to intertwine in the 1950s when the founder of dendrochronology, A. E. Douglass, provided dated wood samples for Willard Libby to test his emerging 14C methods. Since this early connection, absolutely dated tree-rings have been key to calibration of the Holocene portion of the 14C timescale. In turn, 14C dating of non-calendar-dated tree-rings has served to place those samples more precisely in time, advance development of long tree-ring chronologies, and bring higher resolution to earlier portions of the 14C calibration curve. Together these methods continue to shape and improve chronological frameworks across the globe, answering questions in archaeology, history, paleoclimatology, geochronology, and ocean, atmosphere, and solar sciences.
Decolonization Struggles at the United Nations: The Question of Algeria, 1955-1961
Authors: Saeed Sadia 
Published: December 2021

AbstractAlthough national self-determination emerged as an international legal norm with the formation of the United Nations (UN) in 1945, its implementation continued to be resisted by European colonial powers for decades after. This raises the following question: how was European colonial rule challenged at the UN? This article contends that existing accounts of decolonization have not fully theorized the processes through which colonialism was contested at the UN. It fills this gap by demonstrating the critical role of argumentation, narrativization and discursive struggles through deploying the crucial “Question of Algeria” that was debated between 1955 and 1961. It demonstrates that the Algerian question yielded two opposing discourses—an anticolonial internationalist discourse and a metrocentric civilizational discourse—with both drawing on distinct ideas about human rights and development. The analysis explains the eventual triumph of the former as states increasingly rallied behind the Algerian cause.
Who Authored On Liberty? Stylometric Evidence on Harriet Taylor Mill's Contribution
Authors: Schmidt-Petri Christoph , Schefczyk Michael , Osburg Lilly 
Published: December 2021

AbstractIt is well known that John Stuart Mill (JSM) repeatedly acknowledges Harriet Taylor Mill's (HTM) substantial contribution to On Liberty. After her death, however, he decides to publish the book under his name only. Are we justified in continuing this practice, initiated by JSM, of refusing unequivocal co-authorship status to HTM? Drawing on stylometric analyses, we make a preliminary case that JSM did not write On Liberty all by himself and that HTM had a hand in formulating it. Drawing on plausible standards for authorship ascription, we further point out that authorship status requires, in addition to a substantial contribution, the approval by all contributors. We discuss potential reasons to assume that HTM did not approve the published version of On Liberty and would have objected to including her name on the title page.
Workforce demographics and unit structure in paediatric cardiac critical care in the United States
Authors: Horak Robin V. , Bai Shasha , Marino Bradley S. , Werho David K. , Rhodes Leslie A. , Costello John M. , Cabrera Antonio G. , Cooper David S. , Tan Yubo , Tabbutt Sarah , Krawczeski Catherine D. 
Published: December 2021

AbstractObjective:To assess current demographics and duties of physicians as well as the structure of paediatric cardiac critical care in the United States.Design:REDCap surveys were sent by email from May till August 2019 to medical directors (“directors”) of critical care units at the 120 United States centres submitting data to the Society of Thoracic Surgeons Congenital Heart Surgery Database and to associated faculty from centres that provided email lists. Faculty and directors were asked about personal attributes and clinical duties. Directors were additionally asked about unit structure.Measurements and main results:Responses were received from 66% (79/120) of directors and 62% (294/477) of contacted faculty. Seventy-six percent of directors and 54% of faculty were male, however, faculty <40 years old were predominantly women. The majority of both groups were white. Median bed count (n = 20) was similar in ICUs and multi-disciplinary paediatric ICUs. The median service expectation for one clinical full-time equivalent was 14 weeks of clinical service (interquartile range 12, 16), with the majority of programmes (86%) providing in-house attending night coverage. Work hours were high during service and non-service weeks with both directors (37%) and faculty (45%).Conclusions:Racial and ethnic diversity is markedly deficient in the paediatric cardiac critical care workforce. Although the majority of faculty are male, females make up the majority of the workforce younger than 40 years old. Work hours across all age groups and unit types are high both on- and off-service, with most units providing attending in-house night coverage.
Using MERSCOPE to Generate a Cell Atlas of the Mouse Brain that Includes Lowly Expressed Genes
Authors: Emanuel George , He Jiang 
Published: December 2021

Abstract:The structure and organization of cells within organs is essential to their function, but nowhere in the body is this more spectacular than the brain. There, sprawling, snowflake-like neurons have grown into a precise arrangement, reaching out to neighboring cells to form neural circuits. Communication within neural circuits, made possible by spatial positioning, forms the basis of our physiology. Recently, a high-resolution cell atlas generated by MERFISH (multiplex error-robust fluorescence in situ hybridization) technology has mapped this spectacular organ with unmatched resolution, depth, and scale. The atlas catalogs cells as they exist in the intact biological system and will allow us to learn more about rare cell types and sparsely expressed cell signaling receptors fundamental to health and disease.
The Civilizing Mission Persists
Authors: Gill Timothy M. 
Published: December 2021

AbstractU.S. government leaders have long considered Latin America their proverbial backyard and have recurrently intervened in the region. In earlier periods of U.S. imperialism, U.S. government leaders justified such intervention with reference to allegedly scientific racial hierarchies, which placed White, Anglo-Saxon Protestants (WASPs) at the top of this artificial hierarchy. In more recent episodes of U.S. imperialism leading into the twenty-first century, however, U.S. leaders have publicly used the language of democracy and human rights to justify intervention. In the instance of contemporary Venezuela, while U.S leaders indeed use the language of human rights and democracy, they also draw on racist tropes of Latin Americans to justify their intervention. Through interviews with U.S. foreign policymakers and analysis of U.S. government documents, I find that U.S. leaders depict former Venezuelan President Hugo Chávez as an irrational, uncivilized, and beastly leader, who manipulates ideas of racial inequality to maintain power. In addition, U.S. leaders understand him as manipulating an uncritical mass of Venezuelans who cannot think for themselves. U.S. leaders believe it thus their duty to intervene in order to promote democracy and show Venezuelans their true political-economic interests. I connect these dynamics with a history of U.S. intervention into the region and a history of racist and imperial thinking that continues to shape the logic of U.S. foreign policymaking into the present.
SZEMERÉDI’S THEOREM: AN EXPLORATION OF IMPURITY, EXPLANATION, AND CONTENT
Authors: RYAN PATRICK J. 
Published: December 2021

AbstractIn this paper I argue for an association between impurity and explanatory power in contemporary mathematics. This proposal is defended against the ancient and influential idea thatpurityand explanation go hand-in-hand (Aristotle, Bolzano) and recent suggestions that purity/impurity ascriptions and explanatory power are more or less distinct (Section 1). This is done by analyzing a central and deep result of additive number theory, Szemerédi’s theorem, and various of its proofs (Section 2). In particular, I focus upon the radically impure (ergodic) proof due to Furstenberg (Section 3). Furstenberg’s ergodic proof is striking because it utilizes intuitively foreign and infinitary resources to prove a finitary combinatorial result and does so in a perspicuous fashion. I claim that Furstenberg’s proof is explanatory in light of its clear expression of a crucial structural result, which provides the “reason why” Szemerédi’s theorem is true. This is, however, rather surprising: how can such intuitively different conceptual resources “get a grip on” the theorem to be proved? I account for this phenomenon by articulating a new construal of the content of a mathematical statement, which I callstructural content(Section 4). I argue that the availability of structural content saves intuitive epistemic distinctions made in mathematical practice and simultaneously explicates the intervention of surprising and explanatorily rich conceptual resources. Structural content also disarms general arguments for thinking that impurity and explanatory power might come apart. Finally, I sketch a proposal that, once structural content is in hand, impure resources lead to explanatory proofs via suitably understood varieties of simplification and unification (Section 5).
First study of the bat fossil record of the mid-Atlantic volcanic islands
Authors: GONZÁLEZ-DIONIS Javier , CASTILLO RUIZ Carolina , CRUZADO-CABALLERO Penélope , CADAVID-MELERO Elena , CRESPO Vicente D. 
Published: December 2021

ABSTRACTBats are one of the most abundant and important mammals in ecosystems. However, their fossil record is scarce and fragile, making them difficult to find. Accordingly, there is no record of this group in the volcanic islands of the mid-Atlantic Ocean apart from the Canary Islands. This paper studies the first bat fossil record of the Canary Islands (Spain). The material studied is found within two Quaternary lava tubes, Cueva de los Verdes on Lanzarote and Cueva Roja on the island of El Hierro. The dental and humeral morphology and biometry are analysed and compared with current specimens. Among our results we highlight the first fossil data of two species endemic to the islands of the mid-Atlantic Ocean,Plecotus teneriffaeandPipistrellus maderensis, the former from the Canary Islands and the latter from the Azores, Madeira and the Canary Islands. We also confirm the presence ofPipistrellus kuhliiin the fossil record of the island of Lanzarote. No differences are observed between the dental morphology of the current and the fossil populations ofP. maderensisandPl. teneriffae. In the case ofP. kuhlii, the populations of the Canary Islands and the Iberian Peninsula show differences in the paraconule with respect to the populations from central Europe. Palaeoecological studies of these taxa suggest that these islands presented a similar habitat when the sites were formed to the present-day habitat.
The relationship between international humanitarian law and asset freeze obligations under United Nations sanctions
Authors: Onishi Kosuke 
Published: December 2021

AbstractWhile challenges may persist with respect to the relationship between counterterrorism (CT) and humanitarian action, it is at least understood that CT measures must comply with international humanitarian law (IHL). Clarifying the relationship between this body of law and CT measures is one of the modest but important innovations of United Nations (UN) Security Council Resolution 2462. At a minimum, references to IHL in this resolution leave a pathway for States to take measures to preserve impartial humanitarian action from the effects of CT, and at most, they prescribe that States should take such measures. Progress in clarifying the relationship between UN sanctions obligations and IHL obligations appears to be lacking with respect to non-CT-related UN sanctions. As will be discussed in this paper, this leads to questions regarding the application of the so-called “supremacy clause” contained in Article 103 of the UN Charter vis-à-vis IHL obligations.
Three‐Dimensional Free Gas Flow Focuses Basin‐Wide Microbial Methane to Concentrated Methane Hydrate Reservoirs in Geological System
Authors: You Kehua , Summa Lori , Flemings Peter , Santra Manasij , Fang Yi 
Published: December 2021

AbstractWe present a systematic model that links the generation, migration, phase partitioning, and accumulation of methane into a closed loop as the sediment is deposited from the seafloor and buried through the base of hydrate stability zone (BHSZ). In our model, methane is generated by biodegradation of organic carbon in muds. Hydrate does not form and methane is not trapped until a coarse‐grained layer is deposited, because the small pores prevent hydrate formation in muds. Instead, methane diffuses into sands/silts where methane solidifies into hydrate. As hydrate‐bearing sands/silts pass through the BHSZ during sediment burial, methane hydrate dissociates, and releases free gas. The released and the newly generated free gas below the BHSZ concentrates into a vertical/dipping zone with low capillary entry pressure and high permeability and flows upward driven its buoyancy. When free gas reaches the hydrate stability zone (HSZ), capillary forces drive free gas to flow laterally, preferentially enter sands/silts, feed hydrate growth, and elevate hydrate saturation. With three‐dimensional focused free gas flow, microbial methane that is generated from a much larger fetch area of the entire basin, both above and below the BHSZ, is concentrated into coarse‐grained layers at structural closures for hydrate formation. Our model illustrates how geological evolution, microbial methane generation, and gas flow by buoyancy couple to generate concentrated hydrate deposits in geological system. These insights can be used to explore for high‐concentration methane hydrate and are important for understanding the methane budget and carbon cycle under the seafloor.