bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contributions of Brain Function and Structure to Three Different Domains of Cognitive Control in Normal Aging
Authors: Rieck Jenny R. , Baracchini Giulia , Grady Cheryl L. 
Published: February 2021

Abstract
Cognitive control involves the flexible allocation of mental resources during goal-directed behavior and comprises three correlated but distinct domains—inhibition, shifting, and working memory. The work of Don Stuss and others has demonstrated that frontal and parietal cortices are crucial to cognitive control, particularly in normal aging, which is characterized by reduced control mechanisms. However, the structure–function relationships specific to each domain and subsequent impact on performance are not well understood. In the current study, we examined both age and individual differences in functional activity associated with core domains of cognitive control in relation to fronto-parietal structure and task performance. Participants (n = 140, aged 20–86 years) completed three fMRI tasks: go/no-go (inhibition), task switching (shifting), and n-back (working memory), in addition to structural and diffusion imaging. All three tasks engaged a common set of fronto-parietal regions; however, the contributions of age, brain structure, and task performance to functional activity were unique to each domain. Aging was associated with differences in functional activity for all tasks, largely in regions outside common fronto-parietal control regions. Shifting and inhibition showed greater contributions of structure to overall decreases in brain activity, suggesting that more intact fronto-parietal structure may serve as a scaffold for efficient functional response. Working memory showed no contribution of structure to functional activity but had strong effects of age and task performance. Together, these results provide a comprehensive and novel examination of the joint contributions of aging, performance, and brain structure to functional activity across multiple domains of cognitive control.
Joining the Global Environmental Protection Movement: an Exploration of Public Environmental Concern in the UAE
Authors: Alibeli Madalla , Nair Satish 
Published: February 2021

Abstract
This study explores levels of concern about the environment in the United Arab Emirates (UAE). Data for the study were obtained from the 2019 ‘Levels of Concern about the Environment in the UAE’ survey. A convenience sample of 1520 respondents were selected, contacted and interviewed by research assistants. Per the study’s findings, respondents did endorse three out of five dimensions of the Revised NEW Ecological Paradigm scale including the anthropocentric view of nature, balance of nature, and the possibility of eco-crisis. Nevertheless, respondents failed to support the other two dimensions of the given paradigm: limit to growth and human Exemptionalism.
Resilience to Extreme Rainfall Starts with Science
Authors: Wright Daniel B. , Samaras Constantine , Lopez-Cantu Tania 
Published: February 2021

AbstractIntensification of extreme rainfall due to climate change means that federally published rainfall metrics such as the “100-yr storm” are outdated throughout much of the United States. Given their central role in a wide range of infrastructure designs and risk management decisions, updating these metrics to reflect recent and future changes is essential to protect communities. There have been considerable advances in recent years in data collection, statistical methods, and climate modeling that can now be brought to bear on the problem. Scientists must take a lead in this updating process, which should be open, inclusive, and leverage recent scientific advances.
Importance of Human-Induced Nitrogen Flux Increases for Simulated Arctic Warming
Authors: Lim Hyung-Gyu , Park Jong-Yeon , Dunne John P. , Stock Charles A. , Kang Sung-Ho , Kug Jong-Seong 
Published: February 2021

AbstractHuman activities such as fossil fuel combustion, land-use change, nitrogen (N) fertilizer use, emission of livestock, and waste excretion accelerate the transformation of reactive N and its impact on the marine environment. This study elucidates that anthropogenic N fluxes (ANFs) from atmospheric and river deposition exacerbate Arctic warming and sea ice loss via physical–biological feedback. The impact of physical–biological feedback is quantified through a suite of experiments using a coupled climate–ocean–biogeochemical model (GFDL-CM2.1-TOPAZ) by prescribing the preindustrial and contemporary amounts of riverine and atmospheric N fluxes into the Arctic Ocean. The experiment forced by ANFs represents the increase in ocean N inventory and chlorophyll concentrations in present and projected future Arctic Ocean relative to the experiment forced by preindustrial N flux inputs. The enhanced chlorophyll concentrations by ANFs reinforce shortwave attenuation in the upper ocean, generating additional warming in the Arctic Ocean. The strongest responses are simulated in the Eurasian shelf seas (Kara, Barents, and Laptev Seas; 65°–90°N, 20°–160°E) due to increased N fluxes, where the annual mean surface temperature increase by 12% and the annual mean sea ice concentration decrease by 17% relative to the future projection, forced by preindustrial N inputs.
Neutrophil Extracellular Traps Promote Joint Injury in Hemophilia
Authors: Kaminski Tomasz W. , Brzoska Tomasz , Tutuncuoglu Egemen , Ragni Margaret V. , Sundd Prithu 
Published: February 2021

Hemophilic arthropathy (HA) is the predominant pathophysiology resulting from recurrent joint bleeding in individuals with hemophilia. HA leads to permanent joint damage, chronic pain and reduced quality of life. Despite major advances in the treatment to prevent joint bleeding, HA continues to be a major morbidity affecting hemophilia patients and the etiological mechanism contributing to the progression of HA remains elusive. Recent evidence suggests that joint-bleeding may promote the release of erythrocyte and tissue-derived damage-associated-molecular-pattern molecules (DAMPs) that can trigger the sterile inflammation in the joints, however, the innate immune pathways contributing to the development of HA remain unclear. Here, we used a model of knee joint injury-induced HA in FVIII-total knockout (F8TKO) mice and blood samples from hemophilia patients diagnosed with HA. In vivo multi-photon-excitation (MPE) fluorescence imaging of injured synovial cavity in live F8TKO or control mice was used to assess NETs formation within joint capsule. Imaging-flow-cytometry and ELISA assays were used to evaluate the number of circulating NETs in patients diagnosed with HA and mice with knee-injury. Scoring of the bleeding severity, histology, IHC and confocal imaging of joints were conducted to assess the joint injury in mice. F8TKO but not control mice manifested knee-joint injury and severity of bleeding 5-days post knee-injury. Progression of knee-joint injury was associated with increased neutrophil accumulation and NETs shedding within the synovium of F8TKO mice. Circulating NETs were significantly abundant in the plasma of hemophilia patients diagnosed with HA and F8TKO following knee-injury but not plasma of control humans or mice. These findings are the first to suggest that NETs contribute to pathogenesis of HA in hemophilia. Currently, experiments are underway to identify the innate immune pathways that promote NETs shedding, leading to joint-damage in hemophilia.

Disclosures
Ragni: Alnylam/Sanofi, ATHN, BioMarin, Bioverativ, Sangamo, Spark: Research Funding; Alnylam/Sanofi, BioMarin, Bioverativ, Spark: Consultancy; BioMarin: Consultancy, Research Funding; Bioverativ: Consultancy, Research Funding; Spark: Consultancy, Research Funding; Takeda: Research Funding; Sangamo: Consultancy, Research Funding; Alnylam Pharmaceuticals Inc., Baxalta/Takeda, BioMarin, Bioverativ, and Spark Therapeutics: Membership on an entity's Board of Directors or advisory committees; American Thrombosis Hemostasis Network: Other: Committee work; Baxalta/Takeda, CSL Behring, Genentech, a member of the Roche Group, OPKO Biologics, and Vascular Medicine Institute: Research Funding.
Comparative studies on wood structure and microtensile properties between compression and opposite wood fibers of Chinese fir plantation
Authors: Li Zhu , Zhan Tianyi , Eder Michaela , Jiang Jiali , Lyu Jianxiong , Cao Jinzhen 
Published: February 2021

AbstractThe microtensile properties of mechanically isolated compression wood (CW) and opposite wood (OW) tracheids of Chinese fir (Cunninghamia lanceolata) were investigated and discussed with respect to their structure. Major differences in the tensile modulus and ultimate tensile stress were found between CW and OW fibers. Compared to OW, CW showed a larger cellulose microfibril angle, less cellulose content and probably more pits, resulting in lower tensile properties. These findings contribute to a further understanding of the structural–mechanical relationships of Chinese fir wood at the cell and cell wall level, and provide a scientific basis for better utilization of plantation softwood.
Linkage analysis, GWAS, transcriptome analysis to identify candidate genes for rice seedlings in response to high temperature stress
Authors: Wei Zhaoran , Yuan Qiaoling , Lin Hai , Li Xiaoxia , Zhang Chao , Gao Hongsheng , Zhang Bin , He Huiying , Liu Tianjiao , Jie Zhang , Gao Xu , Shi Shandang , Wang Bo , Gao Zhenyu , Kong Lingrang , Qian Qian , Shang Lianguang 
Published: February 2021

AbstractBackgroundRice plants suffer from the rising temperature which is becoming more and more prominent. Mining heat-resistant genes and applying them to rice breeding is a feasible and effective way to solve the problem.ResultThree main biomass traits, including shoot length, dry weight, and fresh weight, changed after abnormally high-temperature treatment in the rice seedling stage of a recombinant inbred lines and the naturalindicagermplasm population. Based on a comparison of the results of linkage analysis and genome-wide association analysis, two loci with lengths of 57 kb and 69 kb inqDW7andqFW6, respectively, were associated with the rice response to abnormally high temperatures at the seedling stage. Meanwhile, based on integrated transcriptome analysis, some genes are considered as important candidate genes. Combining with known genes and analysis of homologous genes, it was found that there are eight genes in candidate intervals that need to be focused on in subsequent research.ConclusionsThe results indicated several relevant loci, which would help researchers to further discover beneficial heat-resistant genes that can be applied to rice heat-resistant breeding.
Yes- mind the gap!
Authors:   TraumaRegister DGU, Hamsen Uwe , Drotleff Niklas , Lefering Rolf , Gerstmeyer Julius , Schildhauer Thomas Armin , Waydhas Christian 
Published: February 2021

AbstractWe totally agree with Deana and Colleagues that missing intermediate care 1) might be an explanation for unexpected unfavorable outcome and 2) strengthening of intermediate care has the potential to lower this high rate of unfavorable outcome after ICU discharge. Yes- mind the gap!
Rural healthcare providers coping with clinical care delivery challenges: lessons from three health centres in Ghana
Authors: Bawontuo Vitalis , Adomah-Afari Augustine , Amoah Williams W. , Kuupiel Desmond , Agyepong Irene Akua 
Published: February 2021

Abstract
Background
Rural settings in low- and middle-income countries are bedeviled with poverty and high disease burden, and lack adequate resources to deliver quality healthcare to the population. Drug shortage and inadequate number and skill-mix of healthcare providers is very common in rural health facilities. Hence, rural healthcare providers have no choice but to be innovative and introduce some strategies to cope with health delivery challenges at the health centre levels. This study explored how and why rural healthcare providers cope with clinical care delivery challenges at the health centre levels in Ghana.

Methods
This study was a multiple case studies involving three districts: Bongo, Kintampo North, and Juaboso districts. In each case study district, a cross-sectional design was used to explore the research question. Purposive sampling technique was used to select study sites and the study participants. The authors conducted 11 interviews, 9 focus group discussions (involving 61 participants), and 9-week participant observation (in 3 health centres). Transcription of the voice-recordings was done verbatim, cleaned and imported into the Nvivo version 11 platform for analysis. Data was analysed using the inductive content analysis approach. Ethical clearance was granted by the Ethics Review Committee of the Ghana Health Service.

Results
The study found three main coping strategies (borrowing, knowledge sharing and multi-tasking). First, borrowing arrangements among primary health care institutions help to address the periodic shortage of medical supplies at the health centres. Secondly, knowledge sharing among healthcare providers mitigates skills gap during service delivery; and finally, rural healthcare providers use multi-tasking to avert staff inadequacy challenges during service delivery at the health centre levels.

Conclusion
Borrowing, knowledge sharing, and multi-tasking are coping strategies that are sustaining and potentially improving health outcomes at the district levels in Ghana. We recommend that health facilities across all levels of care in Ghana and other settings with similar challenges could adopt and modify these strategies in order to ensure quality healthcare delivery amidst delivery challenges.
Self-perceived workplace discrimination and mental health among immigrant workers in Italy: a cross-sectional study
Authors: Di Napoli Anteo , Rossi Alessandra , Baralla Francesca , Ventura Martina , Gatta Rosaria , Perez Monica , Sarchiapone Marco , Mirisola Concetta , Petrelli Alessio 
Published: February 2021

Abstract
Background
The process of immigration is associated with poor mental and physical health. While the workplace represents an important context of social integration, previous studies evaluating the effect of discrimination experienced in the workplace found worse mental health status among immigrants. The aim of this study was to investigate whether self-perceived workplace discrimination has any role in the mental health status of immigrants living and working in Italy, evaluating the contribution of other personal experiences, such as loneliness and life satisfaction.

Methods
A cross-sectional study was conducted on a sample of 12,408 immigrants (aged 15–64) living and working in Italy. Data were derived from the first national survey on immigrants carried out by the Italian National Institute of Statistics (Istat). Mental health status was measured through the Mental Component Summary (MCS) of the SF-12 questionnaire. A linear multivariate linear regression was carried out to evaluate the association between mental health status, self-perceived workplace discrimination, and sociodemographic factors; path analysis was used to quantify the mediation effect of self-perceived loneliness, level of life satisfaction, and the Physical Component Summary (PCS).

Results
Mental health status was inversely associated (p < 0.001) with self-perceived workplace discrimination (β:-1.737), self-perceived loneliness (β:-2.653), and physical health status (β:-0.089); it was directly associated with level of life satisfaction (β:1.122). As confirmed by the path analysis, the effect of self-perceived workplace discrimination on MCS was mediated by the other factors considered: self-perceived loneliness (11.9%), level of life satisfaction (20.7%), and physical health status (3.9%).

Conclusions
Our study suggests that self-perceived workplace discrimination is associated with worse mental health status in immigrant workers through personal experiences in the workplace and explains the effect of the exposure to workplace discrimination on immigrants’ psychological well-being. Our findings suggest that an overall public health response is needed to facilitate the social integration of immigrants and their access to health services, particularly those services that address mental health issues.
Consequences of COVID-19 crisis for persons with HIV: the impact of social determinants of health
Authors: Waterfield Kristie C. , Shah Gulzar H. , Etheredge Gina D. , Ikhile Osaremhen 
Published: February 2021

Abstract
Background
With the indiscriminate spread of COVID-19 globally, many populations are experiencing negative consequences such as job loss, food insecurity, and inability to manage existing medical conditions and maintain preventive measures such as social distancing and personal preventative equipment. Some of the most disadvantaged in the COVID-19 era are people living with HIV/AIDS and other autoimmune diseases.

Discussion
As the number of new HIV infections decrease globally, many subpopulations remain at high risk of infection due to lack of or limited access to prevention services, as well as clinical care and treatment. For persons living with HIV or at higher risk of contracting HIV, including persons who inject drugs or men that have sex with men, the risk of COVID-19 infection increases if they have certain comorbidities, are older than 60 years of age, and are homeless, orphaned, or vulnerable children. The risk of COVID-19 is also more significant for those that live in Low- and Middle-Income Countries, rural, and/or poverty-stricken areas. An additional concern for those living the HIV is the double stigma that may arise if they also test positive for COVID-19. As public health and health care workers try to tackle the needs of the populations that they serve, they are beginning to realize the need for a change in the infrastructure that will include more efficient partnerships between public health, health care, and HIV programs.

Conclusion
Persons living with HIV that also have other underlying comorbidities are a great disadvantage from the negative consequences of COVID-19. For those that may test positive for both HIV and COVID-19, the increased psychosocial burdens stemming from stress and isolation, as well as, experiencing additional barriers that inhibit access to care, may cause them to become more disenfranchised. Thus, it becomes very important during the current pandemic for these challenges and barriers to be addressed so that these persons living with HIV can maintain continuity of care, as well as, their social and mental support systems.
Effect of oblique headless compression screw fixation for metacarpal shaft fracture: a biomechanical in vitro study
Authors: Chiu Yung-Cheng , Ho Tsung-Yu , Ting Yen-Nien , Tsai Ming-Tzu , Huang Heng-Li , Hsu Cheng-En , Hsu Jui-Ting 
Published: February 2021

Abstract
Background
Metacarpal shaft fracture is a common fracture in hand trauma injuries. Surgical intervention is indicated when fractures are unstable or involve considerable displacement. Current fixation options include Kirschner wire, bone plates, and intramedullary headless screws. Common complications include joint stiffness, tendon irritation, implant loosening, and cartilage damage.

Objective
We propose a modified fixation approach using headless compression screws to treat transverse or short-oblique metacarpal shaft fracture.

Materials and methods
We used a saw blade to model transverse metacarpal neck fractures in 28 fresh porcine metacarpals, which were then treated with the following four fixation methods: (1) locked plate with five locked bicortical screws (LP group), (2) regular plate with five bicortical screws (RP group), (3) two Kirschner wires (K group), and (4) a headless compression screw (HC group). In the HC group, we proposed a novel fixation model in which the screw trajectory was oblique to the long axis of the metacarpal bone. The entry point of the screw was in the dorsum of the metacarpal neck, and the exit point was in the volar cortex of the supracondylar region; thus, the screw did not damage the articular cartilage. The specimens were tested using a modified three-point bending test on a material testing system. The maximum fracture forces and stiffness values of the four fixation types were determined by observing the force–displacement curves. Finally, the Kruskal–Wallis test was adopted to process the data, and the exact Wilcoxon rank sum test with Bonferroni adjustment was performed to conduct paired comparisons among the groups.

Results
The maximum fracture forces (median ± interquartile range [IQR]) of the LP, RP, HC, and K groups were 173.0 ± 81.0, 156.0 ± 117.9, 60.4 ± 21.0, and 51.8 ± 60.7 N, respectively. In addition, the stiffness values (median ± IQR) of the LP, HC, RP, and K groups were 29.6 ± 3.0, 23.1 ± 5.2, 22.6 ± 2.8, and 14.7 ± 5.6 N/mm, respectively.

Conclusion
Headless compression screw fixation provides fixation strength similar to locked and regular plates for the fixation of metacarpal shaft fractures. The headless screw was inserted obliquely to the long axis of the metacarpal bone. The entry point of the screw was in the dorsum of the metacarpal neck, and the exit point was in the volar cortex of the supracondylar region; therefore the articular cartilage iatrogenic injury can be avoidable. This modified fixation method may prevent tendon irritation and joint cartilage violation caused by plating and intramedullary headless screw fixation.
A novel posterior multiple screws distraction reducer system versus anterior release, posterior internal distraction, and subsequent spinal fusion for severe scoliosis
Authors: Feng Ganjun , Huang Yong , Huang Leizhen , Wang Yongliang , Wang Juehan , Zhou Chunguang , Wang Lei , Zhou Zhongjie , Yang Xi , Liu Limin , Song Yueming 
Published: February 2021

Abstract
Purpose
We previously reported anterior release, posterior internal distraction, and subsequent spinal fusion (ARPIDF) for the correction of severe scoliosis with a satisfactory correction rate. However, surgical procedures were completed in 2–3 stages. Here we compare Cobb angle of ≥90° in scoliosis correction between a novel posterior multiple screws distraction reducer (MSDR) system and ARPIDF.

Methods
Thirty-six patients with severe scoliosis treated by MSDR or ARPIDF (n = 18 in both groups). We retrospectively analyzed and compared outcome measures between the two groups over a minimum follow-up duration of 2 years. The following variables were compared between the two groups: age at surgery, sex, etiology, flexibility of the main thoracic curve, number of fused segments and screws, operation time, estimated blood loss, hospitalization time, follow-up duration, various radiological parameters, complication rate, and Scoliosis Research Society-30 score.

Results
There were no significant between-group differences with respect to age, sex, etiology, flexibility of the main thoracic curve, number of fused segments and screws, and follow-up duration. Further, there was no significant difference in terms of preoperative, postoperative, and final follow-up findings of the radiographic data. However, the ARPIDF group had longer operation and hospitalization times and greater blood loss. In the ARPIDF group, 4 patient developed complications (infection, intraoperative neuromonitoring changes, transient dyspnea); none of these events occurred in the MSDR group.

Conclusion
The use of MSDR helped achieve greater scoliosis correction with a shorter operation time, lower blood loss, and lower complication rate than the use of ARPIDF. MSDR facilitates safer and easier correction of severe scoliosis without increasing surgical risk.