bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delivery Room Intensive Care Unit: 5 Years' Experience in Assistance of High-Risk Newborns at a Referral Center
Authors: Buratti Silvia , Lampugnani Elisabetta , Faggiolo Monica , Buffoni Isabella , Paladini Dario , De Tonetti Gabriele , Tuo Giulia , Marasini Maurizio , Mattioli Girolamo , Moscatelli Andrea 
Published: April 2021

Objective: The aim of the study is to describe a delivery room intensive care unit (DRICU) model and evaluate its effectiveness in preventing morbidity and mortality in high-risk newborns.Design: This retrospective case series includes all DRICU procedures performed from 2016 to 2020.Setting: Gaslini Children's Hospital is a major pediatric tertiary care center where high-risk pregnancies are centralized. The Neonatal and Pediatric Intensive Care Unit admits every year about 100 high-risk newborns.Patients: The selected patients are newborns at risk of critical conditions immediately after birth for respiratory or cardiovascular congenital disorders.Interventions: The perinatal plan is defined by the multidisciplinary team of Fetal and Perinatal Medicine. The DRICU procedure provides highly specialized care through a protocol that includes logistics, personnel, equipment, and clinical pathways.Main Outcome Measures: The primary outcome is the prevention of acute complications and mortality in the delivery room and early neonatal period.Results: From 2016 to 2020, 40 DRICU procedures were performed. The main prenatal diagnoses included congenital heart disease with a high risk of life-threatening events immediately after birth (38%), congenital diaphragmatic hernia (35%), and fetal hydrops/hydrothorax (23%). Mean gestational age was 35.9 weeks (range: 31–39), and mean birth weight was 2,740 grams (range: 1,480–3,920). DRICU assistance completed in all patients by neonatal intensivists included tracheal intubation and arterial and central venous cannulation; complex procedures such as ex-utero intrapartum technique and extracorporeal membrane oxygenation cannulation are described. No deaths nor severe acute complications occurred in the delivery room or in the immediate postnatal period.Conclusions: The outcome in critical newborns is potentially affected by planned assistance strategies and specialized competencies through the implementation of a DRICU protocol.
7-Ethyl-10-Hydroxycamptothecin, a DNA Topoisomerase I Inhibitor, Performs BRD4 Inhibitory Activity and Inhibits Human Leukemic Cell Growth
Authors: Wang Airong , Li Lingling , Li Mengya , Wang Shujuan , Wang Chong 
Published: April 2021

7-Ethyl-10-hydroxycamptothecin (SN-38) is an active metabolite of CPT-11, which can inhibit DNA topoisomerase I, DNA synthesis and cause frequent DNA single-strand breaks. In our study, SN-38 was characterized as a potent and reversible BRD4 inhibitor [IC50 = 660.2 nM against BRD4 (BD1) and IC50 = 547.7 nM against BRD4 (BD2)] in biochemical assay using drug repurposing strategy. Additional cellular assay suggested that SN-38 can bind BRD4 in human leukemic cell K562 and inhibit cell growth with IC50 = 0.2798 μM in a BRD4 dependent manner partially. Additionally, mechanism study indicated that SN-38 can induce the accumulation of BRD4 substrate c-Myc and cleavage of caspase 3. In sum, our findings identified BRD4 as a new target of SN-38 and reveals SN-38 as a modifier of histone acetylation reader for the first time, which may provide a new insight for further optimization of dual target inhibitor.
Progression to unscheduled hospital admissions in people with diabetes: a qualitative interview study
Authors: Perrin Nikki ED , Heaton Janet , MacRury Sandra M , Friel Kathleen M , Coates Vivien 
Published: April 2021

BackgroundPeople with diabetes often have difficulty maintaining optimal blood glucose levels, risking progressive complications that can lead to unscheduled care. Unscheduled care can include attending emergency departments, ambulance callouts, out-of-hours care, and non-elective hospital admissions. A large proportion of non-elective hospital admissions involve people with diabetes, with significant health and economic burden.AimTo identify precipitating factors influencing diabetes-related unscheduled hospital admissions, exploring potential preventive strategies to reduce admissions.Design & settingThirty-six people with type 1 (n= 11) or type 2 (n= 25) diabetes were interviewed. They were admitted to hospital for unscheduled diabetes-related care across three hospitals in Scotland, Northern Ireland, and the Republic of Ireland. Participants were admitted for peripheral limb complications (n= 17), hypoglycaemia (n= 5), hyperglycaemia (n= 6), or for comorbidities presenting with erratic blood glucose levels (n= 8).MethodFactors precipitating admissions were examined using framework analysis.ResultsThree aspects of care influenced unscheduled admissions: perceived inadequate knowledge of diabetes complications; restricted provision of care; and complexities in engagement with self-care and help-seeking. Limited specialist professional knowledge of diabetes by staff in primary and community care, alongside inadequate patient self-management knowledge, led to inappropriate treatment and significant delays. This was compounded by restricted provision of care, characterised by poor access to services — in time and proximity — and poor continuity of care. Complexities in patient engagement, help-seeking, and illness beliefs further complicated the progression to unscheduled admissions.ConclusionDedicated investment in primary care is needed to enhance provision of and access to services. There should be increased promotion and earlier diabetes specialist team involvement, alongside training and use of technology and telemedicine, to enhance existing care.
Recursos tecnológicos empleados en infocentros por facilitadores de las provincias de Azuay y Cañar
Authors: González-Andrade Blanca Azucena , García-Herrera Darwin Gabriel , Cabrera-Berrezueta Luis Bolívar , Erazo-Álvarez Juan Carlos 
Published: April 2021

La investigación tiene su objetivo en analizar el uso y aplicación de los recursos tecnológicos por parte de los facilitadores de los infocentros de las provincias de Azuay y Cañar. Siendo de carácter descriptivo correlacional no experimental transeccional. Se revela una intima relación entre las variables de uso de presentaciones mediante powtoon y clases impartidas mediante plataformas como: Zoom, Classroom, Facebook live, entre otras, así se puede observar que dichos recursos tecnológicos despiertan el interés en los facilitadores para su posible aplicación dentro de estos espacios comunitarios llamados infocentros. Evidenciándose la estrecha relación que existe entre la aplicación y predisposición por parte de un 80% de facilitadores para aplicar nuevos recursos tecnológicos
Tecnologías digitales como estrategia para la formación de educación sexual
Authors: Mazzilli-Palacios Ruth Pamela , Garcia-Herrera Darwin Gabriel , Álvarez-Lozano María Isabel , Erazo-Álvarez Juan Carlos 
Published: April 2021

El objetivo de la investigación fue analizar de qué manera el uso de metodologías adecuadas y la aplicación de tecnologías digitales para la enseñanza de educación sexual puede contribuir a un aprendizaje significativo en los estudiantes de bachillerato. Mediante alcance descriptivo correlacional no experimental transeccional, mediante análisis de Chi-cuadrado de Pearson, aplicándose encuesta y cuestionario de 19 preguntas a 155 estudiantes. La información que dan los padres de familia sobre sexualidad si influye en los conocimientos de los jóvenes. Se demuestra que los padres de familia presentan un gran conflicto a la hora de abordar temas referentes a la sexualidad, en este estudio se reveló que aún existen limitaciones en el proceso de obtención de información por parte de los familiares, dada por la insuficiente preparación en esta área educativa. Existe la necesidad de abordar en forma integral, dinámica y creativa las clases de salud sexual.
Transversalidad curricular de la educación ambiental desde la acción del docente de Educación Básica
Authors: Cárdenas-Naranjo Nubia Constanza 
Published: April 2021

La educación constituye el conjunto de acciones que contribuye y permiten la enseñanza-aprendizaje en términos reales adaptadas al contexto social, desde la realidad. El presente artículo se planteó como objetivo general analizar la importancia de la educación ambiental desde la transversalidad curricular y la acción del docente de educación básica. Partiendo del paradigma cuantitativo, la investigación es de tipo documental, ya que se puntualiza exclusivamente en la recopilación de información de diversas fuentes. Para con estos datos analizar, describir, sintetizar y deducir las posibles conclusiones del tema. En función de lo planteado, se realizó un análisis de contenido de trabajos relevantes, donde se refleja la transversalidad curricular de la educación ambiental desde la acción del docente de educación básica. Se concluye que la toma de conciencia para asumir responsabilidad frente a una sociedad en constante cambio, garantizan un ciudadano responsable ante sus iguales con espíritu conservacionista para preservar el medio ambiente.
La teoría crítica como alternativa de desarrollo profesional en la disciplina de Enfermería
Authors: Pinargote-Chancay Rosa-del-Rocío , Ponce-Lino Leonela Lissett , Figueroa-Cañarte Fátima Monserrate , Muñiz-Toala Sandra Jazmín 
Published: April 2021

La investigación tiene por objetivo caracterizar la teoría crítica como una alternativa de desarrollo profesional en la disciplina de enfermería. Metodológicamente de corte bibliográfico – documental; donde la hermenéutica se constituyó en la principal fuente de generación de información y con un diseño fue no-experimental. El corpus del estudio lo constituyeron las lecturas relacionadas a teorías en enfermería, contenidas en diferentes textos, artículos científicos y de opinión disponibles en la web. Con el surgimiento de las teorías críticas, nació la necesidad de fundamentar teóricamente las cuatro disciplinas de los metaparadigmas, entre estas; ser humano, ambiente, salud y enfermería, cada una bajo diferentes enfoques.
Point of Care Ultrasound during the Medical Teaching Rounds in the COVID-19 Era -The Hospitalist Perspective-
Authors: Espana Schmidt Christian , Alam Warda 
Published: April 2021

In Internal Medicine, POCUS is gaining significant favorability. An increasing number of clinicians are interested in being trained for POCUS. The newer portable ultrasounds are small and can be transported easily during rounds. Their design is now for a more intuitive use. Training of Internists now involves assessing patients utilizing POCUS technology in residency. Here at Danbury Hospital, we have formal POCUS training. Attending internists are now attempting to incorporate POCUS training as a part of continuing medical education. POCUS in the hospitalist or general practitioner world has not been completely defined. Generally, the patient seen in the medical ward is not ill as the patients seen in intensive care units (ICU), Emergency Department (ED), and other high acute-care settings. However, from time to time, internists need to treat high acuity patients on the medical floors before transferring them to a higher level of care or when they are required to cover an open ICU or Progressive Care Unit (step-down unit). The role of POCUS while managing stable patients may differ significantly compared to the role in more acute patients. A well-defined spectrum for the use of POCUS does not currently exist. However, there are efforts in this regard.
POCUS is an emerging and exciting diagnostic modality in the medical ward. We believe that the pandemic has given it a new meaning for the hospitalist and general practitioner, and we expect that its use and significance will only grow in the few years ahead.
Optimization of head computed tomography scan in a tertiary institution in Edo State, South-South Nigeria
Authors: Udo Chikezie Chukwuemeka , Omojola Akintayo Daniel , Nzotta Chukwuemeka Christian 
Published: April 2021

Objective: The study is aimed at optimizing the existing CT protocol for head scans in a Specialist Teaching Hospital in Edo State with a 16-slice Siemens Somatom Emotion scanner. Also, the study determined the volume computed tomography dose index (CTDIvol) and Dose Length Product (DLP) from the patient's dose profiles. The results from this study were compared with relevant studies.
Materials and Methods: The scanner was used to acquire head CT of 160 patients retrospectively. Also, a locally designed head phantom was used to simulate individual patients using a similar protocol by changing the tube current (mA) and total scan width (TSW) only from the existing protocol.
Results: Percentage dose reduction (PDR) for the CTDIvol and DLP ranged 42.00-46.80% and 37.13-43.54% respectively. The optimized CTDIvol and DLP were lowest compared to studies in the United Kingdom (UK), Italy, India, Ireland, Sudan, Nigeria, European Commission (EC), United States of America (USA) and Japan. Only the DLP for India was lower than our optimized value.
Conclusion: The need to understudy CT configuration is necessary, this will allow end-users to optimize certain parameters in the CT scanner, which will reduce the patient dose without compromising image quality
Evaluation of the prevalence and seasonality of human parainfluenza virus over five year period in pediatric patients
Authors: Colak Meryem , Yigit Selin , Tapisiz Anil , Muftah Hager , Yuce Kenan , Tezer Hasan , Bozdayi Gulendam 
Published: April 2021

Objective: Human Parainfluenza viruses (HPIVs) cause respiratory tract infections, and the second most common cause of acute respiratory illness-related hospitalizations after the respiratory syncytial virus in children <5 years of age. The aim of the study; determination of HPIVs positivity and common types in pediatric patients with respiratory tract infection; investigation the distribution of HPIV positivity by age groups, months and seasons, respectively.
Material and Method: HPIV results of 1613 pediatric patients who were sent to the molecular virology laboratory from various pediatric clinics of Gazi Hospital between March 2016 and February 2021 (five years period) were investigated. Nucleic acid isolation was performed on the EZ1 Advanced (Qiagen, Germany) device using the EZ1 Virus Mini Kit by the manufacturer's protocol.
Results: HPIV positivity was detected as 4.1% in clinical samples and, the most common HPIV type was found to be HPIV-3 (55%). The distribution of other HPIV types were; HPIV-2, HPIV-4 and HPIV-1 with 26%, 23% and 14%, respectively. HPIV-3 is the most common type in 2016, 2017, 2018 and 2019; however, HPIV-1 is the most common type in 2020. HPIVs co-infection was detected with other respiratory tract viruses in 51% of samples. The highest HPIV co-infection was detected in Rhinovirus. The highest HPIV positivity rate (45%) were determined in the 0-2 age group compared to other age groups (p<0.05). The highest positivity rate was in October in the autumn season (p<0.05), the lowest was in January and February in winter. The highest rate (8.1%) of HPIV positivity was found in 2016 and the lowest rate (0.7%) was in 2020.
Conclusions: Since it is not possible to diagnose viral etiology of respiratory tract infections based on clinical findings, viral respiratory tract panel and Multiplex real-time PCR test are a fast and useful method in early diagnosis, treatment decision and prevention of unnecessary antibiotic use. HPIVs positivity is seen at higher rates in children aged 0-2 and in autumn months with seasonal differences.
Perspectives of postgraduate professors and students on internationalization and English language use at a university in the south of Brazil
Authors: Diniz de Figueiredo Eduardo Henrique , Jordão Clarissa Menezes , Antunes Bryan Pissinini , Emmerich Alan , Cons Thais Rodrigues 
Published: April 2021

The aim of the present study is to understand how internationalization has been understood, lived, and discursively constructed by postgraduate students and faculty members at a publicly funded university in the south of Brazil. Through data generated using questionnaires and interviews (with 406 and 19 participants, respectively), we observed at this university that there are discrepancies between how student and faculty participation in the process of internationalization is perceived. We also identified inconsistencies in relation to the understandings of the role of foreign languages in this process. The results show that internationalization is conceptualized as the establishment of interpersonal, intercultural, and inter-institutional relationships (as defended by Martinez, 2017). They also point to two specific needs: a) for more student involvement in discussions over the internationalization process of the university; and b) for a plurilingual understanding of the status of English within this process.
Key words: Internationalization, Higher Education, English language, Brazil, global South
How to cite this article: de Figueiredo, E.H.D., Jordão, C.M., Antunes, B.P., Emmerich, A. & Cons, T.R. 2021. Perspectives of postgraduate professors and students on internationalization and English language use at a university in the south of Brazil. Scholarship of Teaching and Learning in the South. 5(1): 6-24. DOI: 10.36615/sotls.v5i1.158.
This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Music, Contentious Politics, and Identity: A Cultural Analysis of “Aksi Bela Islam” March in Jakarta (2016)
Authors: Hidayatullah Rahmat 
Published: April 2021

This article examines the role of music as a repertoire of contention and as a framing device used to challenge the political legitimacy of the rulers and strengthen the collective identity of the participants in “Aksi Bela Islam” (ABI), a demonstration held in Jakarta at the end of 2016. Rizieq Shihab, one of the key actors of ABI, wrote two songs known as “Si Ahok Durjana” and “Mars Aksi Bela Islam”. This paper argues that the success of mass mobilization during ABI cannot be separated from the creative use of media and popular culture—including music. The key actors of ABI used music and popular media as framing devices to communicate cognitive meanings, mobilize potential adherents, delegitimize authorities, instill emotional feelings and awaken the collective identity of Muslims. This paper applies new social movement theory that emphasizes the significance and role of cultural factors in the dynamics of social movements.
Клиничен случай с централен хиповентилационен синдром, дължащ се на мутация на PHOX2B гена
Authors: Станчева Малина , Масларска Радка , Георгиева Ралица , Транг Ха , Бужемла Имен , Вера Лиза , Бургад Карла , Льо Морван Нели , Капри Илин 
Published: April 2021

Централният хиповентилационен синдром (или болест на Ondine–Hirschprung) е рядко, автозомно доминантно заболяване, което се дължи на мутации на PHOX2B гена. Характеризира се с нарушен автономен контрол на дишането и намалена чувствителност към хиперкапния и хипоксия.
Авторите представят момче на 4 години и 3 месеца, проследявано от раждането. В ранния неонатален период са наблюдавани дихателни паузи и апнеи, мускулна хипотония, гърчов синдром. Магнитно-резонансна томография на глава визуализира перивентрикулна и интравентрикулна хеморагия, перивентрикулна левкомалация. Допълнително се установяват респираторен дистрес синдром, двустранна нефрокалциноза, вторичен дефект тип форамен овале с ляво-десен шънт, значителна синусова аритмия с чести синусови паузи, изолирани аурикуларни екстрасистоли, гастроезофагеалин рефлукс, лицев дизморфизъм. ДНК анализ на PHOХ2B гена установява данни за хетерозиготна мутация в екзон 3, дупликация 18p6, засягаща рамката на четене, която води до експанзия на 6 аланинови остатъка (26 аланина) в С-терминалния край на PHOX2B гена.
Проведена е комплексна животоспасяваща терапия в неонаталния период. При изписването от болницата до 3-годишна възраст е оставен в дома на спонтанно дишане през трахеостома и подпомагане с режим sIMV50%/50% през нощта. След отстраняване на трахеостомата продължава да провежда неинвазивна апаратна вентилация по време на сън.
Разходи за лечение на съпътстващи заболявания при пациенти с акромегалия – преглед на литературата
Authors: Камушева Мария , Русенова Яница , Първанова Алексина , Въндева Силвия , Еленкова Атанаска 
Published: April 2021

Цел: Целта на настоящата разработка е да се систематизират и анализират наличните доказателства относно финансовата тежест на съпътстващите заболявания при пациентите с акромегалия.
Материал и методи: Проведено е литературно търсене в научни бази данни PubMed, Google Scholar, Bioseek по предварително зададени ключови думи. Селектирани са проучвания за пациенти с акромегалия, при които е оценяванa финансовата тежест на съпътстващите заболявания.
Резултати: От общо 176 идентифицирани проучвания са селектирани 16, които отговарят на изследователския въпрос. Преобладаващият брой проучвания са проведени в САЩ (n=6), Канада (n=2), Швеция (n=2), Китай (n=1), Испания (n=1), Италия (n=1), Полша (n=1). Проучванията потвърждават финансовата тежест на съпътстващите заболявания, която е най-значима при пациенти с недобър контрол на основното заболяване - близо 2 пъти по-висока в сравнение с пациети с добър контрол. Разходите за съпътстващите заболявания варират в различните държави и в зависимост от вида на заболяването, като техният дял е по-малък от този на разходите за фармакотерапия на акромегалия - 25% спрямо 75%. Приложението на подходяща фармакотерапия (octreotide, pasireotide) за акромегалия води до намаляване на честотата и тежестта на съпътстващите заболявания и до спестявания на свързаните разходи.
Заключение: Ефективният и навременен контрол на съпътстващите заболявания при акромегалия води до постигане на желаните дългосрочни терапевтични резултати, намаляване на общата смъртност, подобряване на качеството на живот, както и до намаляване на общите разходи за лечение от гледна точка на обществото и системата на здравеопазване.
РЕКОМЕНДАЦІЇ ЗА ПІДСУМКАМИ МЕТОДОЛОГІЧНОГО СЕМІНАРУ НАПН УКРАЇНИ «АКТУАЛЬНІ ПРОБЛЕМИ ПСИХОЛОГІЧНОЇ ПРОТИДІЇ НЕГАТИВНИМ ІНФОРМАЦІЙНИМ ВПЛИВАМ НА ОСОБИСТІСТЬ В УМОВАХ СУЧАСНИХ ВИКЛИКІВ» (8 квітня 2021 р.)
Authors: Національна академія педагогічних наук України  
Published: April 2021

8 квітня 2021 р. відбувся методологічний семінар Національної академії педагогічних наук України «Актуальні проблеми психологічної протидії негативним інформаційним впливам на особистість в умовах сучасних викликів», у рамках якого розглядалися психологічні особливості розвитку особистості в сучасних соціокультурних умовах, психологічна безпека особистості та спільноти в контексті сучасних суспільних викликів, формування медіаінформаційної культури та громадянської компетентності учнів і студентів, психологічна допомога особистості в умовах пандемії COVID-19 та пов’язаних з нею інформаційних ризиків. Організаторами семінару виступили: Відділення психології, вікової фізіології та дефектології, Інститут психології імені Г.С. Костюка, Інститут соціальної та політичної психології, Інститут спеціальної педагогіки і психології імені Миколи Ярмаченка, Український науково-методичний центр практичної психології і соціальної роботи НАПН України. За підсумками методологічного семінару запропоновано рекомендації органам державної влади, науковим організаціям, педагогічним колективам закладів дошкільної, загальної середньої, професійної (професійно-технічної), фахової передвищої та вищої освіти, працівникам засобів масової інформації, професійним об’єднанням психологів з метою вирішення зазначеної проблеми.