bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Volume Controlled and Pressure Controlled Ventilation Modes on Cerebral Oximetry and Blood Gas Status in Laparoscopic Cholecystectomy, A Randomized Controlled Trial
Authors: Badur Emre , Altınay Mustafa , Sayın Pınar , Çınar Ayşe Surhan , türkoğlu leyla , yücel tuğba 
Published: October 2021

Abstract
Background: To compare the volume-controlled and pressure-controlled ventilation modes with near infrared spectroscopy (NIRS) cerebral oximetry and blood gas status in laparoscopic cholecystectomyMethods: Seventy patients (n=70), who underwent elective laparoscopic cholecystectomy operation were randomized into two groups (volume control ventilation - group V, pressure control ventilation - group P). Demographic data (age, gender, body mass index) and operative data (anesthesia, surgery, and insufflation durations) were recorded. Patients’ single derivation electrocardiogram, pulse oximetry, non-invasive arterial pressure, NIRS cerebral oximetry and end-tidal CO2 parameters were recorded. Measurements were done at the start of anesthesia (T0), at the end of intubation (T1), 5 minutes after the insufflation (T2), at the time just before desufflation (T3) and 5 minutes after desufflation (T4).The patients’ heart rate, systolic and diastolic arterial pressure, saturation of pulse oximetry, and NIRS values were recorded for time points. Additionally, arterial gas results and mechanical ventilation parameters were recorded as well. Results: No significant difference was found in age, sex, body mass index. Operation, anesthesia and insufflation durations were similar for the groups. In Group P, NIRS right T1-2-3 averages and NIRS left T2-3 averages were significantly higher than Group V (p=0.030, p=0.001, p=0.001, p=0.006, p=0.002 respectively). In Group P T1-T2-T4, mean peak pressures and mean plateau pressures were significantly lower than Group V (p=0.003, p=0.001, p<0.001, p=0.011, p=0.001, p<0.001 respectively).Conclusion: Mechanical ventilation that performed in pressure-control ventilation mode is resulted with better tissue oxygenation than volume-control ventilation mode. In pressure-control ventilation mode, peak pressure and plateau pressure were lower.Registration of study at ClinicalTrials.gov was made at 25/01/2021 with the NCT04723043 number.
Can a Meteorological Variable Be Considered As a Predictor of COVID-19 Cases in Urban Agglomerations of Indian Cities?
Authors: Chelani Asha B. , Gautam Sneha 
Published: October 2021

Abstract
Coronavirus has been identified as one of the deadliest diseases and WHO has declared it as pandemic and global health crisis. It has become a massive challenge for humanity. India is also being facing its fierceness as it is highly infectious and mutating at a rapid rate. Many interventions have been applied in India since the first reported cases i.e. on January 30, 2020. Several studies have been conducted to assess the impact of climatic and weather conditions on its spread in the last year span. As it is a well-established fact that temperature and humidity could trigger the onset of diseases such as influenza and respiratory disorders, the association of several meteorological variables has been studied in the past with the COVID-19 related number of cases. The conclusions in those studies were based on the data obtained at the early stage and it was too early to draw any inference. This study attempted to assess the influence of temperature, humidity, wind speed, dew point, previous day’s number of deaths, and government intervention’s effect on the number of COVID-19 confirmed cases in 18 districts of India. It is also attempted to identify the important predictors of number of confirmed COVID-19 cases in those districts. The random forest model and the hybrid model obtained by modelling the random forest model's residuals are used to predict the response variable. It is observed that meteorological variables are useful only to some extent that too when used with the data on number of the previous day’s deaths and lockdown information in predicting the COVID-19 cases. Partial lockdown is more important than the complete or no lockdown in predicting the number of confirmed COVID-19 cases. The information is useful to policy makers in balancing the restriction activities and economic losses to individuals and the government.
The Elliptic Curve Decomposition of Central Conics in the Real Hyperbolic Plane
Authors: Sarli John 
Published: October 2021

Abstract

In [1] we classified the intrinsic conics in H² as distinguished subsets of the projective categories (as described in [2] and [3]) to which they belong. However, their relation within H² to these general conics was not determined beyond locus characterizations. Here we show that any central conic that is not intrinsic is the elliptic curve sum of two intrinsic central conics (properly oriented). First, we use a grid consisting of central intrinsic conics and their orthogonal trajectories to introduce coordinates for H². In any inversive model of H², these two sets of curves comprise a complete set of representatives for the genus 1 curves whose shape invariant j (Jacobi absolute invariant) is real. Given two of the intrinsic conics, their respective intersections with any orthogonal trajectory F can be paired by orientation to the axes of the conics so that the elliptic curve sum of the pair with respect to F lies on the same central conic for any F. This new conic, which is not intrinsic, is considered to be the sum of the two oriented conics. Thus, the addition of two points on F is given by an appropriate intersection with F with a central conic determined by those points, and provides an alternative construction of the group law on an elliptic curve with j≤1. Conversely, any non-intrinsic central conic decomposes as the sum of two intrinsic conics. This decomposition is unique up to split inversion, a quasi-symmetry of H² defined in [1] and reprised in Section 1.
Radiographic Results on Acetabular Cup Placement with the SuperPath Technique: A Retrospective Study of 756 Cases
Authors: Maro Agostino Di , Creaco Santo , Albini Mattia , Latiff Mahfuz , Merlo Marco 
Published: October 2021

Abstract
BackgroundThe Supercapsular percutaneously assisted total hip (SuperPath) technique is a relatively new minimally invasive approach for total hip arthroplasty (THA). Good clinical outcomes related to its use are reported in the literature. Nonetheless, there are still uncertainties about its validity in terms of radiographic outcomes.Purposes of the study are to evaluate the effectiveness of the SuperPath in acetabular cup positioning through radiographic evaluation of acetabular inclination angle (IA) and acetabular anteversion (AA) angle within the safe zone described by Lewinnek; to investigate cases of hip dislocation; to evaluate whether our results differ from those reported in recent literature; to evaluate whether there was a statistically significant radiographic difference in acetabular cup placement between two consecutive years.MethodsBetween January 2016 and December 2019, all SuperPath cases eligible for the study were included. They were operated by three Orthopaedic surgeons with long-standing experience in THA via traditional posterolateral approach and who have performed SuperPath training fellowship. The results were analyzed by statistical analysis.ResultsA retrospective analysis of 756 THAs was performed. Means ± standard deviation (SD) of the radiographic IA and AA were calculated for each year. The average percentage of IA within the Lewinnek's safe zone was from 80% to 85%, while the average percentage of AA was from 76% to 79%. Both IA and AA showed no statistically significant difference between two consecutive years. So, there was no statistically significant improvement regarding the radiographic values between two consecutive years for both IA and AA. There were only two cases of hip dislocations. The radiographic values were similar to recent data in the literature from authors using SuperPath and comparing their results with classical surgical approaches.ConclusionIt is possible to achieve good radiographic values of acetabular cup orientation through the SuperPath within the Lewinnek's safe zone. These results are similar to those reported in the literature by authors using SuperPath. Low rate (0,3 %) of hip dislocations were reported. Therefore, the SuperPath technique represents a good alternative for THA. Nevertheless, there is not a statistically significant improvement in these radiographic parameters over a four-year time.Level of Evidence: Level IV, retrospective study.
Anterior Insular-Nucleus Accumbens Pathway Controls Refeeding-Induced Analgesia Under Chronic Inflammatory Pain Condition
Authors: Lee Grace J , Kim Yea Jin , Lee Kihwan , Oh Seog Bae 
Published: October 2021

Abstract
Feeding behaviors are closely associated with chronic pain in adult rodents. Our recent study revealed that 2 hr refeeding after 24hr fasting (i.e. refeeding) attenuates pain behavior under chronic inflammatory pain conditions. However, while brain circuits mediating fasting-induced analgesia have been identified, the underlying mechanism of refeeding-induced analgesia is still elusive. Herein, we demonstrate that the neural activities in the nucleus accumbens shell (NAcS) and anterior insular cortex (aIC) were increased in a modified Complete Freund’s Adjuvant (CFA)-induced chronic inflammatory pain condition, which was reversed by refeeding. We also found that refeeding reduced the enhanced excitability of aICCamKII–NAcSD2R projecting neurons in this CFA model. Besides, chemogenetic inhibition of aICCamKII–NAcSD2R neural circuit suppressed chronic pain behavior while activation of this circuit reversed refeeding-induced analgesia. Thus, the present study suggests that aICCamKII – NacSD2R neural circuit mediates refeeding-induced analgesia, thereby serving as a potential therapeutic target to manage chronic pain.
TEAD4 Serves as a Prognostic Biomarker and Correlates With Immune Phenotype in Lower-Grade Gliomas
Authors: Chen Mu , Huang Bingsong , Zhu Lei , Chen Kui , Lian Hao , Liu Min , Zhao Kaijun , Zhang Jing , Zhong Chunlong 
Published: October 2021

Abstract
Background: Tumor-infiltrating immune cells (TIICs), which play a pivotal role in the tumor microenvironment, are intimately related to tumor progression and clinical outcome. It remains unclear which factors influence tumor immune infiltration in lower-grade gliomas (LGGs). TEAD4 (TEA Domain Transcription Factor 4) is an essential member of the Hippo pathway that is involved in cancer progression, epithelial-mesenchymal transition, metastasis, and cancer stem cell function across multiple types of cancers. However, the prognostic value of TEAD4 and its association with TIICs in LGG have been hardly studied. Methods: LGG data were obtained from The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA). TEAD4 expression between different groups was compared by R and survival analysis was implemented by Kaplan–Meier curves. In Virto experiments were conducted to investigate the role of TEAD4 in glioma cells. Gene set enrichment analysis (GSEA) and protein-protein interaction (PPI) network were used to investigate the differential biological processes and signaling pathways. Multiple computational methods were employed to estimate the association between TEAD4 expression and tumor microenvironment in LGG. Correlations were analyzed by Spearman correlationResults: TEAD4 expression was up-regulated in higher-grade gliomas and correlated with a poorer clinical outcome. Glioma cell proliferation and migration were promoted by TEAD4 overexpression. GSEA and PPI network indicated that multiple immune-related pathways and hub genes were closely associated with TEAD4 expression in LGG specimens. TEAD4 expression was negatively associated with glioma purity. Multivariate Cox regression analysis indicated that TEAD4 expression and tumor purity were independent prognostic factors in LGG. TEAD4 expression was positively correlated with the infiltration of multiple immune cells, including plasma cells, CD8+ T cells, and macrophages M1 and M2. Correlation analysis showed that the TEAD4 level can predict the efficacy of immune checkpoint blockade therapy. Conclusions: TEAD4 is highly related to glioma malignancy grades and multiple immune cell infiltration, suggesting TEAD4 can serve as a new biomarker for anti-cancer therapies in LGG.
Severe Acute Respiratory Syndrome Coronavirus-2 Seropositivity in South-Central Uganda, During 2019 - 2021
Authors: Ssuuna Charles , Galiwango Ronald Moses , Kankaka Edward Nelson , Kagaayi Joseph , Ndyanabo Anthony , Kigozi Godfrey , Nakigozi Gertrude , Lutalo Tom , Ssekubugu Robert , Wasswa John Bosco , Mayinja Anthony , Nakibuuka Martina Cathy , Jamiru Samiri , Oketch John Baptist , Muwanga Edward , Chang Larry William , Grabowski Mary Kate , Wawer Maria , Gray Ronald , Anderson Mark , Stec Michael , Cloherty Gavin , Laeyendecker Oliver , Reynolds Steven James , Quinn Thomas C. , Serwadda David 
Published: October 2021

Abstract
Background: Globally, key subpopulations such as healthcare workers (HCWs) have a higher risk of contracting SARS-CoV-2. In Uganda, limited access to personal protective equipment amidst lack of clarity on the extent and pattern of the community disease burden may exacerbate this situation. We assessed SARS-CoV-2 antibody seroprevalence among high-risk sub-populations in South-central Uganda, including HCWs, persons within the general population previously reporting experiencing key COVID-19 like symptoms (fever, cough, loss of taste and smell) and archived plasma specimens collected between October 2019 – 18th March 2020, prior to confirmation of COVID-19 in Uganda.Methods: From November 2020 - January 2021, we collected venous blood from HCWs at selected health facilities in South-Central Uganda and from population-cohort participants who reported specific COVID-19 like symptoms in a prior phone-based survey conducted (between May to August 2020) during the first national lockdown. Pre-lockdown plasma collected (between October 2019 and March 18th, 2020) from individuals considered high risk for SARS-CoV-2 infection was retrieved. Specimens were tested for antibodies to SARS-CoV-2 using the CoronaChekTM rapid COVID-19 IgM/IgG lateral flow test assay. IgM only positive samples were confirmed using a chemiluminescent microparticle immunoassay (CMIA) (Architect AdviseDx SARS-CoV-2 IgM) which targets the spike protein. SARS-CoV-2 exposure was defined as either confirmed IgM, both IgM and IgG or sole IgG positivity.Results: The seroprevalence of antibodies to SARS-CoV-2 in HCWs was 21.1% [95%CI: 18.2-24.2]. Of the phone-based survey participants, 11.9% [95%CI: 8.0-16.8] had antibodies to SARS-CoV-2. Among 636 pre-lockdown plasma specimens, 1.7% [95%CI: 0.9-3.1] were reactive. Conclusions: Findings suggest a high seroprevalence of antibodies to SARS-CoV-2 among HCWs and substantial exposure in persons presenting with specific COVID-19 like symptoms in the general population of South-central Uganda. Based on current limitations in serological test confirmation, it remains unclear whether pre-lockdown seropositivity implies prior SARS-CoV-2 exposure in Uganda.
High Prevalence of Myopia and Low Hyperopia Reserve in 4411 Chinese Primary School Students and Associated Risk Factors
Authors: Yue Yu , Liu Xianmao , Yi Shu , Liu Bo , Yi Hong , Li Hong 
Published: October 2021

Abstract
Purpose: To investigate the prevalence of myopia in Chinese primary school students and their ocular biometrics including axial length (AL), corneal radius of curvature (CRC) and spherical equivalent refraction (SER). To analyze their association with potential myopia risk factors, such as body mass index (BMI), cram school, time of outdoor activity and electronic screen use. Methods: In this cross-sectional study of 4500 primary school students from 5 schools, participants underwent refraction using non-cycloplegic autorefractor and visual acuity testing. Myopia was defined as SER ≤ -0.50 diopter (D) and uncorrected visual acuity (UCVA) ＜ 0.00 logMAR (6/6). Logistic regression models were used to determine factors associated with myopia.Results: After excluding 389 participants, the overall prevalence of myopia was 33.6%. The prevalence of high myopia was 0.6%. The prevalence of myopia in girls was significantly higher than that in boys（37.6% vs. 30.0%, p<0.001). The height, weight and BMI were significantly associated with AL (r=0.471, r=0.440, r=0.276, p <0.001, respectively). AL/CRC ratio was more highly correlated with SER than AL alone. Age (p < 0.001), parental myopia (p = 0.001) and lack of outdoor activity between classes (p = 0.049) were independently associated with higher prevalence rates of myopia.Conclusion: The prevalence of myopia among Chinese schoolchildren is alarming high. Consistent with previous cross-sectional data, AL/CRC could function as myopia detection indicator. The hyperopia reserve among children aged between 6 ~7 years was low. Healthcare providers need to raise parents’ awareness of the importance of regular eye examination and proper optical correction.
Towards Causal Analysis of Genetic Factors for Colorectal Cancer
Authors: Miller David , Chockler Hana , Lawrence Andrew , McNamee Daniel , Chia Nicholas 
Published: October 2021

Abstract
We present preliminary results and outline future work for the causal analysis of genetic factors influencing the occurrence and severity of colorectal cancer. The findings are based on publicly available datasets. We show that using relatively simple methods we are able to detect meaningful dependencies, reflecting the current biomedical knowledge about the causes of cancer and related conditions (such as infection and sepsis). We also argue that a deeper analysis, taking into account gene regulation, would require a significantly larger dataset.
Effectiveness of a Peer Support Intervention Program on Obesity Control Among Women in a Rural Area of Turkey
Authors: Sahin Berna Bilgin , Eser Erhan 
Published: October 2021

Abstract
BackgroundObesity in women is one of the leading public health problems globally. Peer support interventions have been effective in many areas of health promotion, and they have also been successful in obesity prevention and treatment.MethodsThis is a quasi-experimental obesity peer-led intervention study called the Leading Woman Model. At baseline, the obesity prevalence was found to be 60.5% among women aged 18–64 (n = 655) living in a rural district of Turkey. Of the participants (n = 137), 86.9% completed the 3rd month and 78.1% the 6th month of the intervention. Leading women (n = 11) were recruited from the community to supervise and monitor their own target groups of women during the intervention, which included supervised balanced nutrition and regular physical activity. ResultsThe mean age of the target intervention group was 42.8 ± 12.2. Significant improvements were observed in the body weight of the participating in the 3rd (-1.15 ± 2.51 kg) and 6th month (-1.13 ± 4.15 kg) of the intervention (p <0.05). Of the women, 10.9% lost at least 5% of their weight by the 3rd month and 13.1% by the 6th month of intervention, and 8.4% and 11.2% of the women achieved a better BMI category in the 3rd and 6th month of intervention, respectively.ConclusionCommunity-based obesity interventions are challenging but much more promising than those based at a facility. We suggest the Leading Women Model for community-based obesity interventions in women.
Incorporation of Humanistic Quality Education Into The Practice of Dermatology and Venereology Training Research
Authors: Qiu Xian-Wen , Mi Xiang-Bin , Wei Shan-Shan , Yan Lu 
Published: October 2021

Abstract
Background
The transformation of the medical pattern into the biological-sociological and psychological medical model has made the importance of humanities in medical education increasingly prominent. This study analyzes the effectiveness and importance of integrating humanistic qualities into clinical teaching in dermatology.
Methods
During July 2016 to August 2020, interns training in Departments of Dermatology, Zhujiang Hospital, 200, according to the order of student number of grouping experimental group and control group, four groups of 50, respectively, the control group of interns on conventional teaching in practice stage, while the experimental group of intern trainee phase combination of humanity quality education in teaching, compared two groups of interns teaching and learning effects.
Results
Medical history collection/interrogation techniques, practical operation and observation of history writing scores of the experimental group of interns were significantly higher than those of the control group, and the experimental group of interns humanistic quality education related indicators were significantly better than the control group (P <0.05).
Conclusions
The results put forward some countermeasures and suggestions for cultivating and optimizing the humanistic care spirit of medical students.
Temporal Evolution of Bacterial Community Structure, Co-Occurrence Patterns, and Community Assembly Process in Epiphytic Biofilms of Submerged Plants in a Plateau Lake
Authors: Shi Lei , Xia Pinhua , Lin Tao , Li Guoqing , Wang Tianyou , Du Xin 
Published: October 2021

Abstract
In shallow macrophytic lakes, epiphytic biofilms are formed on the surface of submerged plant stems and leaves because of the accumulation of algae and bacteria. Epiphytic biofilms have a significant impact on the health of the host vegetation and the biogeochemical cycling of lake elements. However, there is a lack of understanding of the community diversity, species interactions, and community assembly mechanisms in epiphytic bacterial communities (EBC) of plants during different growth periods. We investigated the successional dynamics, co-occurrence patterns, and community building processes of epiphytic biofilm bacterial communities of typical submerged plants, Najas marina and Potamogeton lucens from July, 2020 to November, 2020. The results showed that EBC diversity and abundance varied significantly among seasons, community diversity and abundance increased gradually from July to November, and temperature was the best explanatory factor for predicting seasonal changes in EBC community structure. Co-occurrence network analysis revealed that the average degree and plot density of the network gradually increased from July to November, indicating that the complexity of the EBC network gradually increased. The bacterial community co-occurrence network is mainly limited by temperature, pH, and transparency. The phylogeny-based null model analysis showed that microbial community construction was dominated by deterministic processes in different periods, and their contribution tended to increase gradually. Additionally, we found that as the dominant role of deterministic processes gradually increased, the microbial co-occurrence links also increased and the potential interrelationships between species became stronger. Altogether, these findings provide insights into the seasonal variability of EBC assemblage and co-occurrence patterns in lacustrine ecosystems.