bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global trends in sustainability rating assessment systems and their role in achieving sustainable urban communities in Saudi Arabia
Authors: Hegazy Ibrahim , Helmi Mansour , Qurnfulah Emad , Maddah Rahif , Samir Ibrahim Hossam 
Published: February 2021

Abstract
Sustainability as a concept is tackled a lot in contemporary urbanism due to its importance; consequently, this led to the development of global trends toward achieving it. The current research attempts to identify how sustainability could be achieved in urban design and how to comply with the global concerns. This paper tackles the experiences of the global trends toward sustainability concepts in terms of its application by examining a range of contemporary global urban examples. It depends on a comparative analytical assessment using the ‘Leadership in Energy and Environmental Design (LEED) for Neighborhood Development, LEED-ND’ assessment system in order to address the criteria measuring the sustainability indicators for these examples. These criteria are mainly grouped under the following categories: sustainable planning and design, water management, energy management, waste management, transportation and construction materials and resources. The research mainly aims to identify strategies and criteria assisting in achieving sustainability concept and implementation in urbanism at international level and their role in achieving sustainable urban settlements in Saudi Arabia. In order to achieve this aim, the research methodology includes the following: review of the global sustainability assessment tools, review of the ‘LEED-ND’ assessment system, analytical comparative assessment of ‘King Abdullah University of Science and Technology’ and ‘Masdar City’ according to the ‘LEED-ND’ system as case studies and identifying strategies and criteria that achieve sustainability in urban design and planning.
Influence of Irradiation on the Biology of the Brown Marmorated Stink Bug (Hemiptera: Pentatomidae)
Authors: Nguyen H N , Stringer L D , Hong K-J 
Published: February 2021

AbstractFifth-instar brown marmorated stink bug (Halyomorpha halys Stål) nymphs were treated by gamma-radiation 60Co at different doses of 8–64 Gy to investigate their irradiation biology and potential for the sterile insect technique (SIT). At adult emergence, males were mated with non-irradiated virgin females to assess the longevity of both sexes, female fecundity, and egg sterility. Biological parameters of their F1 progeny were investigated to determine whether negative effects from parental exposure to radiation were inherited. Results showed that irradiation significantly reduced the lifespan of male insects at doses above 20 Gy. Irradiated males did not affect the longevity and fecundity of their female partners, nor of their resulting adult progenies, but it did reduce the developmental duration of nymphs as well as weight gain of male F1 offspring. Egg hatch was significantly reduced at all tested doses and reached complete sterility at 64 Gy. Low hatch of eggs produced by F1 or F1 crossed adults indicated that negative effects from radiation were inherited by the subsequent generation. But F1 male offspring were not less fertile than their irradiated male parent, unlike what was observed in Lepidoptera. The results support the potential for the use of SIT for H. halys management by irradiating the fifth-instar male nymphs at doses from 16 Gy to 64 Gy.
Lethal and Sublethal Effects of Flupyradifurone onBemisia tabaciMED (Hemiptera: Aleyrodidae) Feeding Behavior and TYLCV Transmission in Tomato
Authors: Liu Baiming , Preisser Evan L , Jiao Xiaoguo , Xu Weihong , Zhang Youjun 
Published: February 2021

AbstractPesticides primarily affect target organisms via direct toxicity, but may also alter the feeding behaviors of surviving individuals in ways that alter their effect on host plants. The latter impact is especially important when pests can transmit plant pathogens. The Mediterranean (MED) population of the sweetpotato whitefly Bemisia tabaci Gennadius (Hemiptera: Aleyrodidae) transmits Tomato yellow leaf curl virus (TYLCV), a pathogen that can be economically devastating in field and greenhouse cropping systems. We first assessed the impact of sublethal (LC15) and label concentrations of flupyradifurone, a butenolide-derived insecticide, on the feeding behavior of TYLCV-infected MED on tomato. We next measured the effect of flupyradifurone on plant TYLCV load, vector transmission efficiency, and MED survival. Both the LC15 and label flupyradifurone concentrations dramatically altered MED feeding and caused the near cessation of both salivation and phloem ingestion (necessary for viral transmission and acquisition, respectively). Both concentrations also significantly reduced plant TYLCV load, and the label rate of flupyradifurone sharply decreased TYLCV transmission while killing &gt;99% of MED. As the first report of pesticide-induced changes in the feeding behavior of viruliferous Bemisia, our findings highlight the potential importance of chemically driven feeding cessation in the control of TYLCV and other Bemisia-transmitted plant pathogens.
Small, low-grade ampullary neuroendocrine tumor presenting with metastasis and multiple synchronous tumors in a patient with neurofibromatosis type 1: a case report with literature review
Authors: Xiao Kevin , Swierczynski Sharon , Xiao Gary 
Published: February 2021

ABSTRACT
Neurofibromatosis type 1 (NF1) is a tumor syndrome and one of the most common genetic disorders. Patients have an increased risk of developing neurologic and gastrointestinal (GI) neoplasms, but GI lesions are often underrecognized since most cases are asymptomatic. It is extremely rare to see multiple types of abdominal tumors synchronously in NF1. In this case, we describe a patient presenting with a small, low-grade periampullary neuroendocrine tumor (NET) that underwent endoscopic submucosal dissection and later pancreaticoduodenectomy (Whipple procedure). This led to findings of lymph node and distant metastasis of her NET, and the incidental discovery of gastrointestinal stromal tumors, extensive pancreatic intraepithelial neoplasia, and main duct and side branch intraductal pancreatic mucinous neoplasm. The synchronous presence of these lesions has not been reported in the literature.
Predictors of Symptom Increase in Subsyndromal PTSD Among Previously Deployed Military Personnel
Authors: Highfill-McRoy Robyn M , Levine Jordan A , Larson Gerald E , Norman Sonya B , Schmied Emily A , Thomsen Cynthia J 
Published: February 2021

ABSTRACT

Introduction
Subsyndromal PTSD (sub-PTSD) is associated with functional impairment and increased risk for full PTSD. This study examined factors associated with progression from sub-PTSD to full PTSD symptomatology among previously deployed military veterans.

Materials and Methods
Data were drawn from a longitudinal survey of Navy and Marine Corps personnel leaving military service between 2007 and 2010 administered immediately before separation (baseline) and ~1 year later (follow-up). Survey measures assessed PTSD symptoms at both times; the baseline survey also assessed potential predictors of symptom change over time. Logistic regression models were used to identify predictors of progression from sub-PTSD to full PTSD status.

Results
Compared to those with no or few PTSD symptoms at baseline, individuals with sub-PTSD were almost three times more likely to exhibit full PTSD symptomatology at follow-up. Risk factors for symptom increase among those with sub-PTSD included moderate or high levels of combat exposure and utilization of fewer positive coping behaviors. Use of prescribed psychotropic medication was protective against symptom increase.

Conclusion
This study identified several predictors of symptom increase in military veterans with sub-PTSD. Interventions targeting modifiable risk factors for symptom escalation, including behavioral and pharmacological treatments, may reduce rates of new-onset PTSD in this population.
The EDGE–CALIFA survey: the local and global relations between Σ*, ΣSFR, and Σmol that regulate star formation
Authors: Sánchez S F , Barrera-Ballesteros J K , Colombo D , Wong T , Bolatto A , Rosolowsky E , Vogel S , Levy R , Kalinova V , Alvarez-Hurtado P , Luo Y , Cao Y 
Published: February 2021

ABSTRACT
We present a new characterization of the relations between star-formation rate, stellar mass, and molecular gas mass surface densities at different spatial scales across galaxies (from galaxy-wide to kpc scales). To do so, we make use of the largest sample combining spatially resolved spectroscopic information with CO observations, provided by the Extragalactic Database for Galaxy Evolution (EDGE)–Calar Alto Legacy Integral Field Area (CALIFA) survey, together with new single-dish CO observations obtained by the Atacama Pathfinder Experiment (APEX). We show that these relations are the same at the different scales explored, sharing the same distributions for the explored data, with similar slope, intercept, and scatter (when characterized by a simple power law). From this analysis, we propose that these relations are the projection of a single relation between the three properties that follows a distribution described well by a line in three-dimensional parameter space. Finally, we show that observed secondary relations between the residuals and the parameters considered are explained fully by the correlation between the uncertainties, and therefore have no physical origin. We discuss these results in the context of the hypothesis of self-regulation of the star-formation process.
Systematic review on the use of patient-reported outcome measures in brain tumor studies: part of the Response Assessment in Neuro-Oncology Patient-Reported Outcome (RANO-PRO) initiative
Authors: Dirven Linda , Vos Maartje E , Walbert Tobias , Armstrong Terri S , Arons David , van den Bent Martin J , Blakeley Jaishri , Brown Paul D , Bulbeck Helen , Chang Susan M , Coens Corneel , Gilbert Mark R , Grant Robin , Jalali Rakesh , Leach Danielle , Leeper Heather , Mendoza Tito , Nayak Lakshmi , Oliver Kathy , Reijneveld Jaap C , Le Rhun Emilie , Rubinstein Larry , Weller Michael , Wen Patrick Y , Taphoorn Martin J B 
Published: February 2021

Abstract

Background
The Response Assessment in Neuro-Oncology Patient-Reported Outcome (RANO-PRO) working group aims to provide guidance on the use of PROs in brain tumor patients. PRO measures should be of high quality, both in terms of relevance and other measurement properties. This systematic review aimed to identify PRO measures that have been used in brain tumor studies to date.

Methods
A systematic literature search for articles published up to June 25, 2020 was conducted in several electronic databases. Pre-specified inclusion criteria were used to identify studies using PRO measures assessing symptoms, (instrumental) activities of daily living [(I)ADL] or health-related quality of life (HRQoL) in adult patients with glioma, meningioma, primary central nervous system lymphoma, or brain metastasis.

Results
A total of 215 different PRO measures were identified in 571 published and 194 unpublished studies. The identified PRO measures include brain tumor-specific, cancer-specific, and generic instruments, as well as instruments designed for other indications or multi- or single-item study-specific questionnaires. The most frequently used instruments were the EORTC QLQ-C30 and QLQ-BN20 (n = 286 and n = 247), and the FACT-Br (n = 167), however, the majority of the instruments were used only once or twice (150/215).

Conclusion
Many different PRO measures assessing symptoms, (I)ADL or HRQoL have been used in brain tumor studies to date. Future research should clarify whether these instruments or their scales/items exhibit good content validity and other measurement properties for use in brain tumor patients.
Highly Selective Partial Neurectomy for Lower-Extremity Spasticity: 2-Dimensional Operative Video
Authors: Abou-Al-Shaar Hussam , Mahan Mark A 
Published: February 2021

Abstract
Spasticity is a common debilitating condition after central nervous system injury. The principal therapies—sedating antispasticity medications and focal therapies (eg, botulinum toxin)—may not provide sufficient reduction in tone, have intolerable side effects, and lose efficacy over time. Selective neurectomy is a surgical option for durable reduction in tone.
1-6
Although commonly performed internationally, neurectomies are used less often within the USA. We present the surgical case of a 23-yr-old woman with cerebral palsy and severe spastic diplegia. Medications, injections, and tendon surgeries had failed to relieve her spastic lower extremities. She presented with crouch gait, adductor scissoring, and bilateral equinovarus. She had previously benefitted significantly from bilateral hamstring and obturator neurectomies, with improvement in mobility. She desired tibial neurectomies for her bilateral equinovarus, which impacted her gait substantially. To reduce unwanted plantarflexion and internal rotation tone, selective neurectomies of the motor nerves to the medial and lateral gastrocnemius, soleus, and posterior tibialis muscles were performed. The surgical video details a technique for longitudinally opening the epineurium, separating small nerves into their individual fascicles, and subdividing submillimeter fascicles by approximately 50% to 60% of the fascicle cross-sectional area. She reported significant improvement in gait, her modified Ashworth score dropped from 3 to 0, and her motor power remained unchanged, which is equivalent or better than most published results.
2,7
Neurectomies are a highly effective procedure for focal extremity spasticity. Additional clinical series or trials would help establish the appropriate indications and durability and quantify the risks and benefits. The patient consented to treatment and publication.
Countering social stigma and discrimination during the COVID-19 pandemic through solidarity
Authors: Balingue Ariel C 
Published: February 2021

Abstract
A recent article highlighted the difference between the attitude and mental health of domestic and overseas Chinese college students. It suggests that this difference is due to the social stigma and discrimination inflicted on overseas Chinese students. In this correspondence, the author proposes solidarity, analogous to the Chinese notion of ren, as a means of countering social stigma and discrimination.
The possible threat of faking Covid-19 diagnostic tests and vaccination certifications: a call to an immediate action
Authors: Deguma Melona C , Deguma Jabin J 
Published: February 2021

Abstract
The pandemic’s recessive effect on the global economy created a ‘de-globalized’ process that detrimentally causes financial turmoil to countries whose economy depends on tourism, urban passenger transport services and civil aviation, among others. The need to help the most vulnerable industries non-resilient to the pandemic reopen to aid economic recovery amid the pandemic’s threat is a very urgent concern. With the move to start the vaccination program against the threat of Covid-19, faking Covid-19 diagnostic testing certification pose a severe problem to matters of ethics and economics. If not taken seriously, falsifying documents that certify a person who has undergone Covid-19 vaccination could also happen. This paper argues that everyone’s collective effort could be the real embodiment of hope toward a new normal world immune from the virus and malpractices.
Peroral iron supplementation can be provided to piglets through a milk cup system with results comparable to parenteral iron administration
Authors: Jakobsen Nadia , Pedersen Marie Louise M , Amdi Charlotte 
Published: February 2021

AbstractThe objective of this study was to investigate if iron can be allocated to piglets through sow milk replacer fed in a milk cup system with efficacies comparable to intramuscular (IM) administration of 200 mg gleptoferron. Two hundred and ninety-four piglets from 21 litters were allocated to three different iron treatments (n = 98). The treatments were 1) Control (CON) provided no supplemental iron, 2) Injected iron (II) provided 200 mg gleptoferron IM on day 3 postpartum, and 3) Milk iron (MI) provided sow milk replacer “DanMilk Supreme” added 1 % “Piglet Boozt” ad libitum from day 0 until 21 days postpartum. All piglets had access to dry feed from day 6. Initial and final body weight was registered and hemoglobin (Hb) levels were analyzed on day 0, 3, 7, 10, 17, and 21 after farrowing. In order to correlate drinking pattern with Hb level and growth, video cameras were installed, and drinking pattern was recorded on day 18 postpartum. A blood sample was drawn from piglets from three litters per treatment on day 21 for a complete hematology profile. The results showed that iron treatment had an effect on Hb levels (P &lt; 0.001) that were different between all groups from day 10, resulting in a mean Hb level of 76.2 g/L (CON), 120.9 g/L (II), and 105.4 g/L (MI) on day 21. The mean Hb level for both MI and II was above the anemia threshold of 90 g/L and the Hb level of the II group was above 110 g/L and the piglets thus defined as normal. Treatment had a significant effect on Hb, hematocrit (hct), mean corposcular volume (MCV), mean corpuscular hemoglobin (MCH), red blood cell distribution width (RDW), lymphocytes (%), neutrophils (bill/L) (P &lt; 0.05), neutrophils (%) (P &lt; 0.01), with CON being significantly different from MI and II that were similar or tended to differ. Total visits at the cup was not correlated to Hb level (r = 0.08) and growth was not affected by treatment (P = 0.99). It is concluded that iron can be supplemented to piglets through a milk cup system with efficacies comparable to parenteral administration of 200 mg gleptoferron.
Coronatine Contributes to Pseudomonas cannabina pv. alisalensis Virulence by Overcoming Both Stomatal and Apoplastic Defenses in Dicot and Monocot Plants
Authors: Sakata Nanami , Ishiga Takako , Masuo Shunsuke , Hashimoto Yoshiteru , Ishiga Yasuhiro 
Published: February 2021

Pseudomonas cannabina pv. alisalensis is a causative agent of bacterial blight of crucifers including cabbage, radish, and broccoli. Importantly, P. cannabina pv. alisalensis can infect not only a wide range of Brassicaceae spp. but, also, green manure crops such as oat. However, P. cannabina pv. alisalensis virulence mechanisms have not been investigated and are not fully understood. We focused on coronatine (COR) function, which is one of the well-known P. syringae pv. tomato DC3000 virulence factors, in P. cannabina pv. alisalensis infection processes on both dicot and monocot plants. Cabbage and oat plants dip-inoculated with a P. cannabina pv. alisalensis KB211 COR mutant (ΔcmaA) exhibited reduced virulence compared with P. cannabina pv. alisalensis wild type (WT). Moreover, ΔcmaA failed to reopen stomata on both cabbage and oat, suggesting that COR facilitates P. cannabina pv. alisalensis entry through stomata into both plants. Furthermore, cabbage and oat plants syringe-infiltrated with ΔcmaA also showed reduced virulence, suggesting that COR is involved in overcoming not only stomatal-based defense but also apoplastic defense. Indeed, defense-related genes, including PR1 and PR2, were highly expressed in plants inoculated with ΔcmaA compared with WT, indicating that COR suppresses defense-related genes of both cabbage and oat. Additionally, salicylic acid accumulation increases after ΔcmaA inoculation compared with WT. Taken together, COR contributes to causing disease by suppressing stomatal-based defense and apoplastic defense in both dicot and monocot plants. Here, we investigated COR functions in the interaction of P. cannabina pv. alisalensis and different host plants (dicot and monocot plants), using genetically and biochemically defined COR deletion mutants. [Formula: see text] The author(s) have dedicated the work to the public domain under the Creative Commons CC0 “No Rights Reserved” license by waiving all of his or her rights to the work worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law, 2021.
Viroselect: A novel SARS-CoV-2 detection assay to resolve inconclusive samples
Authors: Jawade Ketki , Sinha Akhauri Yash , Bhagat Sharad , Bhowmick Shilpa , Chauhan Bhagyashree , Kaginkar Snehal , Palav Harsha , Kasarpalkar Nandini , Devadiga Pratik , Karandikar Kalyani , Agarwal Sachee , Shastri Jayanthi , Munne Kiran , Bhor Vikrant M , Mahale Smita D , Bhowmik Subhanjan , Jagtap Dhanashree , Patel Vainav 
Published: February 2021

ABSTRACTBackgroundIndia bears the second largest burden of SARS-CoV-2 infection. A multitude of RT-PCR detection assays with disparate gene targets including automated high throughput platforms are available. Varying concordance and interpretation of diagnostic results in this setting can result in significant reporting delays leading to suboptimal disease management. Here, we report the development of a novel ORF-1a based SARS-CoV-2 RT-PCR assay, Viroselect, showing high concordance with conventional assays and the ability to resolve inconclusive results generated during the peak of the epidemic in Mumbai, India.MethodsWe identified a unique target region within SARS-CoV-2 ORF1a, non-structural protein (nsp3), that was used to design and develop our assay. This hypervariable region (1933-3956) between SARS-CoV-2, SARS-CoV, and MERS-COV was utilized to design our primers and probe for RT-PCR assay. We further evaluated concordance of our assay with commonly used EUA (USFDA) manual kits as well as an automated high throughput testing platform. Further, a retrospective analysis using Viroselect on samples reported as ‘inconclusive’ during April-October 2020 was carried out.ResultsA total of 701 samples were tested. Concordance analysis of 477 samples demonstrated high overall agreement of Viroselect assay with both manual (87.6%; 95% CI) as well as automated (84.7%; 95% CI) testing assays. Also, in the retrospective analysis of 224 additional samples reported as ‘inconclusive’, Viroselect was able to resolve 100% (19/19) and 93.7% (192/205) samples which were termed inconclusive by manual and automated high throughput platform respectively.ConclusionWe show that Viroselect had high concordance with conventional assays, both manual and automated, as well as highlight its potential in resolving inconclusive samples.