bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-intensity physical activity is not associated with better cognition in the elder: evidence from the China Health and Retirement Longitudinal Study
Authors: Wu Zhiyuan , Zhang Haiping , Miao Xinlei , Li Haibin , Pan Huiying , Zhou Di , Liu Yue , Li Zhiwei , Wang Jinqi , Liu Xiangtong , Zheng Deqiang , Li Xia , Wang Wei , Guo Xiuhua , Tao Lixin 
Published: November 2021

Abstract
Background
To evaluate the association of physical activity (PA) intensity with cognitive performance at baseline and during follow-up.

Methods
A total of 4039 participants aged 45 years or above from the China Health and Retirement Longitudinal Study were enrolled in visit 1 (2011–2012) and followed for cognitive function in visit 2 (2013–2014), visit 3 (2015–2016), and visit 4 (2017–2018). We analyzed the association of PA intensity with global cognition, episodic memory, and mental intactness at baseline using adjusted regression methods and evaluated the long-term effect of PA intensity using multiple measures of cognition scores by mixed effect model.

Results
In cross-sectional analysis, mild and moderate PA, rather than vigorous PA, was associated with better cognitive performance. The results remained consistent in multiple sensitivity analyses. During the follow-up, participant with mild PA had a 0.56 (95% CI 0.12–0.99) higher global cognition, 0.23 (95% CI 0.01–0.46) higher episodic memory, and 0.33 (95% CI 0.01–0.64) higher mental intactness, while those with moderate PA had a 0.74 (95% CI 0.32–1.17) higher global score, 0.32 (95% CI 0.09–0.54) higher episodic memory, and 0.43 (95% CI 0.12–0.74) higher mental intactness, compared with individuals without PA. Vigorous PA was not beneficial to the long-term cognitive performance.

Conclusions
Our study indicates that mild and moderate PA could improve cognitive performance, rather than the vigorous activity. The targeted intensity of PA might be more effective to achieve the greatest cognition improvement considering age and depressive status.
Limitations of cardiothoracic ratio derived from chest radiographs to predict real heart size: comparison with magnetic resonance imaging
Authors: Simkus Paulius , Gutierrez Gimeno Manuel , Banisauskaite Audra , Noreikaite Jurate , McCreavy David , Penha Diana , Arzanauskaite Monika 
Published: November 2021

Abstract
Background
Cardiothoracic ratio (CTR) in chest radiographs is still widely used to estimate cardiac size despite the advent of newer imaging techniques. We hypothesise that a universal CTR cut-off value of 50% is a poor indicator of cardiac enlargement. Our aim was to compare CTR with volumetric and functional parameters derived from cardiac magnetic resonance imaging (MRI).

Methods
309 patients with a chest radiograph and cardiac MRI acquired within a month were reviewed to assess how CTR correlates with multiple cardiac MRI variables: bi-ventricular EDV (absolute and indexed to body surface area), EF, indexed total heart volume and bi-atrial areas. In addition, we have also determined CTR accuracy by creating multiple ROC curves with the described variables.

Results
All cardiac MRI variables correlate weakly but statistically significantly with CTR. This weak correlation is explained by a substantial overlap of cardiac MRI parameters in patients with normal and increased CTR. For all variables, CTR was only mildly to moderately better than a chance to discriminate cardiac enlargement (AUC 0.6–0.7). Large CTR values (> 55%) are specific but not sensitive, while low CTR values (< 45%) are sensitive but not specific. Values in between are not sensitive nor specific.

Conclusions
CTR correlates weakly with true chamber size assessed by gold standard cardiac MRI and has a weak discriminatory power. Thus, clinical decisions based on intermediate CTRs (45–55%) should be avoided. Large CTRs (> 55%) are likely indicative of true heart chamber enlargement. Low CTRs (< 45%) are likely indicative of normal heart size.
Correlation between clarithromycin resistance, virulence factors and clinical characteristics of the disease in Helicobacter pylori infected patients in Shahrekord, Southwest Iran
Authors: Hosseini Razieh Sadat , Rahimian Ghorbanali , Shafigh Mohammad Hadi , Validi Majid , Khaledi Mansoor , Gholipour Abolfazl 
Published: November 2021

AbstractThe purpose of this study was to determine the mutations associated with clarithromycin resistance in Helicobacter pylori strains isolated from biopsy samples that were collected from the endoscopic ward of Shahrekord Hajar teaching Hospital and also to study the frequency of virulence factor and their correlation and pathological findings with clarithromycin resistance during the years 2019–2020. In this cross-sectional descriptive study, 152 patients with Helicobacter pylori infection were considered, and then, two common A2142G and A2143G mutations in the 23SrRNA gene associated with resistance were analyzed by Real-time PCR (Taq man). The presence of vacA, iceA1, iceA2, cagA, babA2, and oipA virulence genes was investigated by PCR and electrophoresis in 8% polyacrylamide gel. Then, data were analyzed using the relevant statistical tests. In this study, the frequency of Helicobacter pylori was 76% and the frequency of mutant isolates was 57.2%. The frequencies of A2142G and A2143G point mutations were 42.1% and 28.3%. There was a significant correlation among oipA, vacA, and iceA1 virulence factors, type of disease, chronic inflammatory score, and glandular atrophy with the antibiotic resistance to clarithromycin. There was no significant correlation between the age and sex of the patients with antibiotic resistance. According to the results of this study, it seems that the use of clarithromycin to combat this bacterium should be limited.
Poorer mental well-being and prior unmet need for mental healthcare: a longitudinal population-based study on men in Sweden
Authors: Olsson Sara , Burström Bo , Hensing Gunnel , Löve Jesper 
Published: November 2021

Abstract
Background
Depression and anxiety disorder contribute to a significant part of the disease burden among men, yet many men refrain from seeking care or receive insufficient care when they do seek it. This is plausibly associated with poorer mental well-being, but there is a lack of population-based research. This study investigated 1) if men who had refrained from seeking mental healthcare at any time in life had poorer mental well-being than those who sought care, 2) if those who had sought care but perceived it as insufficient had poorer mental well-being than those who had perceived care as sufficient, and 3) if these differences persisted after 1 year.

Methods
This longitudinal study used questionnaire data from a population-based sample of 1240 men, aged 19–64 years, in Sweden. Having refrained from seeking mental healthcare, or perceiving the care as insufficient, at any time in life, was assessed in a questionnaire, 2008. Current mental well-being was assessed in 2008 and 2009 using mean scores on the WHO (Ten) Well-being Index. Lower scores indicate poorer mental well-being. Group differences were calculated using t-tests and multivariable linear regression analysis.

Results
Of the men who had perceived a need for mental healthcare, 37% had refrained from seeking such care. They had lower mental well-being scores in 2008, compared to those who sought care. Of those seeking care, 29% had perceived it as insufficient. They had lower mental well-being scores in 2008, compared to those who perceived the care as sufficient, but this was not statistically significant when controlling for potential confounders. There were no differences in mental well-being scores based on care-seeking or perceived care-sufficiency in 2009.

Conclusions
This population-based study indicates that men who have previously refrained from seeking mental healthcare, or perceived the care as insufficient, have poorer mental well-being. However, the lack of differences at the one-year follow-up contradicts these results. The results highlight the need for larger longitudinal studies, measuring care-seeking within a more specified time frame. This should be combined with efforts to increase men’s mental healthcare-seeking and to provide mental healthcare that is perceived as sufficient.
The disruptive triad and entrepreneurship: a theoretical model
Authors: Socorro Márquez Félix O. , Reyes Ortiz Giovanni E. 
Published: November 2021

AbstractThe main objective of this study is to propose a theoretical model to understand the importance of disruption—in three of its dimensions, thinking, creativity, and innovation—developed and applied in the thinking and exercise of entrepreneurship and, at the same time, highlight the relationship of the disruption with competitiveness. Being competitive is one of the most demanding goals that entrepreneurs can and should set themselves; however, unlike established or traditional companies, usually the entrepreneur cannot promote competitiveness in the same way that they do. Taking these into account, it is necessary to use unconventional tools, or a different perspective methodology, for promoting creativity and innovation beyond the entrepreneurial activity itself. Through a qualitative methodology, with an emphasis on documentary research and inferential and deductive reasoning, a theoretical model is proposed. The model seeks to illustrate how disruptive currents can help entrepreneurs to be more competitive and, at the same time, boost their entrepreneurial spirit.
Flight rapidly modulates body temperature in freely behaving bats
Authors: Luo Jinhong , Greif Stefan , Ye Huan , Bumrungsri Sara , Eitan Ofri , Yovel Yossi 
Published: November 2021

Abstract
Background
Bats are remarkable in their dynamic control over body temperature, showing both hypothermia with torpor and hyperthermia during flight. Despite considerable research in understanding bats’ thermoregulation mechanisms, knowledge on the relationship between flight and body temperature in bats remains limited, possibly due to technological restraints.

Results
We used onboard dataloggers including a temperature sensor and an inertial sensor (accelerometers) and continuously recorded the flight behavior and skin temperature (Tsk) subcutaneously of a perch-hunting bat, Hipposideros armiger, both in the laboratory and in the field. We provide evidence that flight increases the body temperature of bats. The median of the maximum increase in the Tsk caused by flight bouts was 3.4 °C (between 1.9 and 5.3 °C for different individuals) in the laboratory. The maximum Tsk for the bats was narrowly centered around 40 °C (between 38.5 and 40.9 °C). Moreover, we found that the faster the Tsk rises, the greater the maximum increase in Tsk. Interestingly, bats can slow down the Tsk rises with intermittent fights, during which they perch after brief flight bouts to allow the body temperature to drop rapidly. Similar data were collected from field recordings in free-ranging bats.

Conclusions
We suggest that perch-hunting behavior observed in approximately 200 species of bats that results in intermittent flights may function as a thermoregulatory strategy, in addition to optimizing energy efficiency as demonstrated by previous studies.
Different low-cost materials to prevent the alteration induced by formic acid on unstable glasses
Authors: Arévalo Rodrigo , Mosa Jadra , Aparicio Mario , Palomar Teresa 
Published: November 2021

Abstract
The most frequent cause of glass degradation is environmental moisture, which is adsorbed on its surface forming a hydration layer that induces the rupture of the glass network. This pathology is accelerated by the accumulation of volatile organic compounds (VOCs), like formic acid. Although there is extensive knowledge about their impact, concentrations inside display cases are difficult to reduce efficiently. This study presents the assessment of different materials to reduce the concentration of formic acid to mitigate the degradation produced in unstable glasses. With this objective, copper threads, steel wool, silica gel, and activated carbon were chosen as low-cost materials with good adsorption or reactivity to the VOCs, exposing them in desiccators to an environment of 100% RH and 10 ppm of formic acid. Given that silica gel obtained the best results, its optimization as a sorbent material was evaluated by maintaining, regenerating, or renewing it when exposed next to the same glass. The tests carried out concluded that the hygroscopic capacity of the glasses exposed with silica gel decreased and, therefore, a lower degradation is observed on its surface. In addition, regenerating and renewing weekly the silica gel improved the results.
Getting everyone to the table: exploring everyday and everynight work to consider ‘latent social threats’ through interprofessional tabletop simulation
Authors: Brydges Ryan , Nemoy Lori , Ng Stella , Khodadoust Nazanin , Léger Christine , Sampson Kristen , Campbell Douglas M. 
Published: November 2021

AbstractIn this methodological intersection article, we describe how we developed a new variation of the established tabletop simulation modality, inspired by institutional ethnography (IE)-informed principles. We aimed to design and conduct pilot implementations of this innovative tabletop simulation modality, which focused uniquely on everyday and everynight work, along with the factors that govern that work. In so doing, we aimed to develop a modality and preliminary findings that researchers and educators can use to simulate healthcare practices across longer episodes of care (i.e., time scales of hours or an entire day) and to detect the ‘latent social threats’ that can emerge during interprofessional clinical care.An interprofessional team designed tabletop simulation scenarios of interprofessional challenges during transfers of care on a labour and delivery (L&D) unit. Within each scenario, participants provided real-time explanations for their work and associated drivers, both independently and as a team. Thus, we combined ‘think-aloud’ and simulation principles to design tabletop simulation scenarios to elicit healthcare professionals’ descriptions of how they collaborate in their work on the L&D unit. We completed a total of five tabletop simulations with eight participants (obstetricians, N = 2; midwives, N = 2; nurses, N = 5).The conversations stimulated by the tabletop simulation scenarios and debriefs allowed us to generate a preliminary understanding of the texts that govern and organize clinicians’ everyday work processes. We generated data about longitudinal, multi-hour work processes in a condensed timeline, with opportunities to pause and probe, and with reduced focus on individual practitioner’s competence.We believe our innovative tabletop simulation approach allowed us to examine clinical work in ways no other simulation permits. Participants described how the scenarios opened a productive dialogue between professional groups and suggested this simulation-based approach might contribute to enhanced interprofessional understanding and cultural change. We suggest that others can adapt our low-resource approach to understand clinicians’ everyday work and to map how this work is governed by documents, like policies, with the end goal of facilitating system change and managing latent social threats.
Curiosity and the desire for agency: wait, wait … don’t tell me!
Authors: Metcalfe Janet , Kennedy-Pyers Treva , Vuorre Matti 
Published: November 2021

AbstractPast research has shown that when people are curious they are willing to wait to get an answer if the alternative is to not get the answer at all—a result that has been taken to mean that people valued the answers, and interpreted as supporting a reinforcement-learning (RL) view of curiosity. An alternative 'need for agency' view is forwarded that proposes that when curious, people are intrinsically motivated to actively seek the answer themselves rather than having it given to them. If answers can be freely obtained at any time, the RL view holds that, because time delay depreciates value, people will not wait to receive the answer. Because they value items that they are curious about more than those about which they are not curious they should seek the former more quickly. In contrast, the need for agency view holds that in order to take advantage of the opportunity to obtain the answer by their own efforts, when curious, people may wait. Consistent with this latter view, three experiments showed that even when the answer could be obtained at any time, people spontaneously waited longer to request the answer when they were curious. Furthermore, rather than requesting the answer itself—a response that would have maximally reduced informational uncertainty—in all three experiments, people asked for partial information in the form of hints, when curious. Such active hint seeking predicted later recall. The 'need for agency' view of curiosity, then, was supported by all three experiments.
Molecular insights into the Y-domain of hepatitis E virus using computational analyses
Authors: Shafat Zoya , Hamza Abu , Deeba Farah , Parvez Mohammad K. , Parveen Shama 
Published: November 2021

Abstract
Background
Hepatitis E virus (HEV) of the family Hepeviridae is a major causative agent of acute hepatitis in developing countries. The Y-domain is derived from multi-domain non-structural polyprotein encoded by open reading frame 1 (ORF1). Previous studies have demonstrated the essentiality of Y-domain sequences in HEV life cycle; however, its function remains completely unexplored. The following study was thus conceptualized to examine the detailed computational investigation for the putative Y-domain to estimate its phylogenetic assessment, physiochemical properties, structural and functional characteristics using in silico analyses.

Results
The phylogenetic assessment of Y-domain with a vast range of hosts indicated that the protein was very well conserved throughout the course of evolution. The Y-domain was found to be unstable, hydrophilic and basic in nature with high thermostability value. Structural analysis of Y-domain revealed mixed α/β structural fold of the protein having higher percentage of alpha-helices. The three-dimensional (3D) protein model generated through homology modelling revealed the presence of clefts, tunnels and pore. Gene ontology analysis predicted Y-domain protein’s involvement in several binding and catalytic activities as well as significant biological processes. Mutations in the conserved amino acids of the Y-domain suggested that it may stabilize or de-stabilize the protein structure that might affect its structure–function relationship.

Conclusions
This theoretical study will facilitate towards deciphering the role of unexplored Y-domain, thereby providing better understanding towards the pathogenesis of HEV infection.
A new stability indicating RP-UPLC method for simultaneous estimation of Doravirine, Lamivudine and Tenofovir disoproxil fumarate in bulk and their combined pharmaceutical formulation
Authors: Addanki Swetha , Kuber B. Ramya 
Published: November 2021

Abstract
Background
To establish a simple, sensitive, accurate, precise, efficient, economical RP-UPLC method for simultaneous estimation of Doravirine, Lamivudine and Tenofovir disoproxil fumarate in bulk and their combined pharmaceutical formulations. Optimization of Chromatographic separation was achieved on analytical column HSS C18 (100 × 2.1 mm, 1.8 μ) maintained at temperature 30 °C and mobile phase consisting of 0.01 N Potassium dihydrogen orthophosphate buffer (pH-4.8) and acetonitrile in the ratio 60:40 v/v and at a flow rate 0.3 mL/min in isocratic mode. The injection volume was set as 1 µl detection wavelength is 260 nm. The proposed method validation was done as per International Council on Harmonization Q2 (R1) guidelines.

Results
Doravirine, Lamivudine and Tenofovir disoproxil fumarate were eluted at retention times of 1.2, 1.5, and 1.8 min respectively. The proposed method was identified an excellent linearity over concentration range of 12.5–75.0 µg/mL for Doravirine and 37.5–225.0 µg/mL for Lamivudine and 37.5–225.0 µg/mL for Tenofovir disoproxil fumarate. The percentage relative standard deviation for intra-day and inter-day precision of the present method was less than 2% for Doravirine, Lamivudine and Tenofovir disoproxil fumarate. Accuracy of the present method was evaluated by recovery studies which were in the range of 99.62–99.88% for Doravirine and 98.78–99.44% for Lamivudine and 99.67–100.52% for Tenofovir disoproxil fumarate. The limit of detection and limit of quantification were found to be 0.249 µg/mL and 0.756 µg/mL for Doravirine and 0.24 µg/mL and 0.727 µg/mL for Lamivudine and 0.797 µg/mL and 2.966 µg/mL for Tenofovir disoproxil fumarate. Forced degradation studies were carried out under various stress conditions like acid, base, peroxide, thermal, photo and neutral conditions.

Conclusions
The present method makes sure about no degraded impurity peak interference at the retention time of analyte peak hence can be applied for quality control investigation of Doravirine, Lamivudine and Tenofovir disoproxil fumarate in bulk and pharmaceutical formulations.
A new technological approach to the granulation of slag melts of ferrous metallurgy: obtaining glassy fine-grained granules of improved quality
Authors: Sakhvadze David , Jandieri Gigo , Jangveladze Giorgi , Sakhvadze Giorgi 
Published: November 2021

AbstractThe technological factors required to improve the operational properties of granulated metallurgical slags demanded in the building industry have been analyzed. In order to satisfy these factors, a new technology for hydro-vacuum granulation of slag melts (HVG) has been developed. It is shown that the main advantage of the proposed HVG process is the provision of forced high-speed vortex convection of water, with the effect of vertical suction, crushing, and degassing of the three-phase (water–slag granules–water vapor) heterogeneous medium formed during the overcooling and solidification of slag. It is proved that the high-speed volumetric disintegration and overcooling with the degassing effect sharply reduces a degree of aggressive gas/vapor impact on the being cooled particles of slag, which, in turn, leads to the reduction of the perforation degree of the granules. The obtained granules are distinguished by stable fractionation and improved, well-defined dense amorphous glassy structure, the water-holding capacity of which has reduced from 45–50% to 25–13%, the actual moisture content from 24–20% to 6–4%, while the hydraulic activity in terms of CaO-uptake increased from the conventional 320–360 mg/g to 610–650 mg/g. Pilot scale research demonstrated that the designed equipment for the HVG technology allows sustainable control of the quality of granules, and it has the potential for further development and implementation.