bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mid-term implant survival, functional and radiological results and mechanical complications of mega-prosthetic reconstruction around the knee with the PENTA® system
Authors: Özger Harzem , Alpan Bugra , Salduz Ahmet , Gurkan Volkan , Sungur Mustafa , Valiyev Natig , Eralp Levent 
Published: August 2021

Abstract
Aim
Mega-prosthetic reconstruction is the most common treatment method for massive osteoarticular defects caused by tumor resection around the knee. The new implant is a highly modular rotational-hinged megaprosthesis system with a distinct pentagonal stem geometry and variable implantation options. The aim of this study is to present the mid-term implant survival characteristics, functional and radiological results and mechanical complication profile of the new megaprosthesis.

Methods
One hundred and one mega-prosthetic knee reconstruction procedures in 90 patients (M/F: 51/39) utilizing the new implant system were retrospectively analyzed. In 68 patients, the megaprosthesis was used for primary reconstruction following tumor resection while it was used for revision of other implants in 22. The mean age was 28.5 (7–66) years and the mean follow-up was 59.2 (24–124) months. The most common primary pathology was osteosarcoma with 63–70% patients, the most common anatomical site of involvement was the distal femur with 56–62% patients.

Results
Henderson Type 2 failure (aseptic loosening) was seen in only 2–2.2% patients while Type 3 (structural failure) was seen in 29–32.2% Although the 5-year anchorage survival rate was 94.3%, overall mechanical implant survival was 76.1% at 5 years due to a relatively high failure rate in the first-generation hinge mechanism of the implant. The 5-year hinge survival rate demonstrated a significant improvement rate from 61.7% to 87.2% between the first and second generations of the implant (p = 0.027). The mean MSTS score was 24 out of 30 (14–29). The mean cumulative ISOLS radiographic score for index megaprosthesis operations was 19.7 (12–24), which corresponded to excellent outcome.

Conclusion
The new megaprosthesis system is a reliable choice for the reconstruction of tumor-related massive osteoarticular defects around the knee. Although long-term follow-up is necessary for a definitive evaluation of the implant's survival characteristics, midterm follow-up yields exceptional anchorage properties related to pentagonal stem geometry with very good functional outcomes.
Tectono-magmatic controls on decratonic gold deposits
Authors: Chang Jia , Audétat Andreas , Li Jian-Wei 
Published: August 2021

AbstractMagmatic-hydrothermal gold–copper deposits in post-subduction settings represent essential targets for mineral exploration, but controls on their formation remain controversial. The early Cretaceous lode Au districts that formed during lithosphere destruction of the North China Craton provide an ideal opportunity to better understand the key tectono-magmatic factors responsible for the genesis of Au-rich deposits in post-subduction settings. Here, we present a LA-ICP-MS study of silicate melt inclusions and sulfide inclusions from ore-related mafic to intermediate rocks in the central Taihangshan Au district in the interior of the North China Craton to constrain the content and evolution of magmatic ore metals ± volatiles. The results, combined with numerical modeling, suggest that the ore-related magmas contained only a few ng/g Au, which is similar to the Au content of non-mineralization-related mafic to intermediate magmas worldwide. The low Au content of the lode Au-related magmas suggest that large volumes of magmas had to accumulate in the middle to lower crust through trans-lithospheric fault systems to produce the lode Au deposits. It is further suggested that the lode Au-related magmas were alkali-rich, hydrous, oxidized and relatively rich in sulfur and chlorine (mafic melt inclusions contain 0.14‒0.24 wt% S and 0.1‒0.2 wt% Cl). These properties are considered critical for the generation of auriferous ore fluids. By comparing the tectono-magmatic setting of the giant Jiaodong Au province (~ 4000 t Au) with the central Taihangshan district (~ 150 t Au), we propose that the much larger total Au tonnage of the Jiaodong district results from the accumulation of a much larger volume of ore-forming magmas at deep crustal levels, induced by a stronger degree of lithosphere modification. In addition, given that the composition of lode Au-related magmas is similar to that of porphyry Cu–Au-related magmas, the lack of giant, early Cretaceous porphyry Cu–Au deposits in the North China Craton suggests that strong extensional settings favor the formation of lode Au deposits instead of porphyry Cu–Au deposits. The present study, therefore, has general implications for the genesis of Au-rich deposits in strongly extensional settings.
A multinational consensus on dysphagia in Parkinson's disease: screening, diagnosis and prognostic value
Authors: Cosentino Giuseppe , Avenali Micol , Schindler Antonio , Pizzorni Nicole , Montomoli Cristina , Abbruzzese Giovanni , Antonini Angelo , Barbiera Filippo , Benazzo Marco , Benarroch Eduardo Elias , Bertino Giulia , Cereda Emanuele , Clavè Pere , Cortelli Pietro , Eleopra Roberto , Ferrari Chiara , Hamdy Shaheen , Huckabee Maggie-Lee , Lopiano Leonardo , Marchese Ragona Rosario , Masiero Stefano , Michou Emilia , Occhini Antonio , Pacchetti Claudio , Pfeiffer Ronald F. , Restivo Domenico A. , Rondanelli Mariangela , Ruoppolo Giovanni , Sandrini Giorgio , Schapira Anthony H. V. , Stocchi Fabrizio , Tolosa Eduardo , Valentino Francesca , Zamboni Mauro , Zangaglia Roberta , Zappia Mario , Tassorelli Cristina , Alfonsi Enrico 
Published: August 2021

Abstract
Background
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by a combination of motor and non-motor dysfunction. Dysphagia is a common symptom in PD, though it is still too frequently underdiagnosed. Consensus is lacking on screening, diagnosis, and prognosis of dysphagia in PD.

Objective
To systematically review the literature and to define consensus statements on the screening and the diagnosis of dysphagia in PD, as well as on the impact of dysphagia on the prognosis and quality of life (QoL) of PD patients.

Methods
A multinational group of experts in the field of neurogenic dysphagia and/or PD conducted a systematic revision of the literature published since January 1990 to February 2021 and reported the results according to PRISMA guidelines. The output of the research was then analyzed and discussed in a consensus conference convened in Pavia, Italy, where the consensus statements were drafted. The final version of statements was subsequently achieved by e-mail consensus.

Results
Eighty-five papers were used to inform the Panel’s statements even though most of them were of Class IV quality. The statements tackled four main areas: (1) screening of dysphagia: timing and tools; (2) diagnosis of dysphagia: clinical and instrumental detection, severity assessment; (3) dysphagia and QoL: impact and assessment; (4) prognostic value of dysphagia; impact on the outcome and role of associated conditions.

Conclusions
The statements elaborated by the Consensus Panel provide a framework to guide the neurologist in the timely detection and accurate diagnosis of dysphagia in PD.
Clinicopathological features and prognostic significance of CTNNB1 mutation in low-grade, early-stage endometrial endometrioid carcinoma
Authors: Ruz-Caracuel Ignacio , López-Janeiro Álvaro , Heredia-Soto Victoria , Ramón-Patino Jorge L. , Yébenes Laura , Berjón Alberto , Hernández Alicia , Gallego Alejandro , Ruiz Patricia , Redondo Andrés , Peláez-García Alberto , Mendiola Marta , Hardisson David 
Published: August 2021

AbstractLow-grade and early-stage endometrioid endometrial carcinomas (EECs) have an overall good prognosis but biomarkers identifying patients at risk of relapse are still lacking. Recently, CTNNB1 exon 3 mutation has been identified as a potential risk factor of recurrence in these patients. We evaluate the prognostic value of CTNNB1 mutation in a single-centre cohort of 218 low-grade, early-stage EECs, and the correlation with beta-catenin and LEF1 immunohistochemistry as candidate surrogate markers. CTNNB1 exon 3 hotspot mutations were evaluated by Sanger sequencing. Immunohistochemical staining of mismatch repair proteins (MLH1, PMS2, MSH2, and MSH6), p53, beta-catenin, and LEF1 was performed in representative tissue microarrays. Tumours were also reviewed for mucinous and squamous differentiation, and MELF pattern. Nineteen (8.7%) tumours harboured a mutation in CTNNB1 exon 3. Nuclear beta-catenin and LEF1 were significantly associated with CTNNB1 mutation, showing nuclear beta-catenin a better specificity and positive predictive value for CTNNB1 mutation. Tumours with CTNNB1 exon 3 mutation were associated with reduced disease-free survival (p = 0.010), but no impact on overall survival was found (p = 0.807). The risk of relapse in tumours with CTNNB1 exon 3 mutation was independent of FIGO stage, tumour grade, mismatch repair protein expression, or the presence of lymphovascular space invasion. CTNNB1 exon 3 mutation has a negative impact on disease-free survival in low-grade, early-stage EECs. Nuclear beta-catenin shows a higher positive predictive value than LEF1 for CTNNB1 exon 3 mutation in these tumours.
Graphical abstract
A stochastic solver based on the residence time algorithm for crystal plasticity models
Authors: Yu Qianran , Martínez Enrique , Segurado Javier , Marian Jaime 
Published: August 2021

AbstractThe deformation of crystalline materials by dislocation motion takes place in discrete amounts determined by the Burgers vector. Dislocations may move individually or in bundles, potentially giving rise to intermittent slip. This confers plastic deformation with a certain degree of variability that can be interpreted as being caused by stochastic fluctuations in dislocation behavior. However, crystal plasticity (CP) models are almost always formulated in a continuum sense, assuming that fluctuations average out over large material volumes and/or cancel out due to multi-slip contributions. Nevertheless, plastic fluctuations are known to be important in confined volumes at or below the micron scale, at high temperatures, and under low strain rate/stress deformation conditions. Here, we develop a stochastic solver for CP models based on the residence-time algorithm that naturally captures plastic fluctuations by sampling among the set of active slip systems in the crystal. The method solves the evolution equations of explicit CP formulations, which are recast as stochastic ordinary differential equations and integrated discretely in time. The stochastic CP model is numerically stable by design and naturally breaks the symmetry of plastic slip by sampling among the active plastic shear rates with the correct probability. This can lead to phenomena such as intermittent slip or plastic localization without adding external symmetry-breaking operations to the model. The method is applied to body-centered cubic tungsten single crystals under a variety of temperatures, loading orientations, and imposed strain rates.
Experimental investigation to characterize simple versus multi scaling analysis of hydraulic conductivity at a mesoscale
Authors: Brunetti Guglielmo Federico Antonio , De Bartolo Samuele , Fallico Carmine , Frega Ferdinando , Rivera Velásquez Maria Fernanda , Severino Gerardo 
Published: August 2021

AbstractThe spatial variability of the aquifers' hydraulic properties can be satisfactorily described by means of scaling laws. The latter enable one to relate the small (typically laboratory) scale to the larger (typically formation/regional) ones, therefore leading de facto to an upscaling procedure. In the present study, we are concerned with the spatial variability of the hydraulic conductivity K into a strongly heterogeneous porous formation. A strategy, allowing one to identify correctly the single/multiple scaling of K, is applied for the first time to a large caisson, where the medium was packed. In particular, we show how to identify the various scaling ranges with special emphasis on the determination of the related cut-off limits. Finally, we illustrate how the heterogeneity enhances with the increasing scale of observation, by identifying the proper law accounting for the transition from the laboratory to the field scale. Results of the present study are of paramount utility for the proper design of pumping tests in formations where the degree of spatial variability of the hydraulic conductivity does not allow regarding them as “weakly heterogeneous”, as well as for the study of dispersion mechanisms.
Modelling of Rock Cutting with Asymmetrical Disc Tool Using Discrete-Element Method (DEM)
Authors: Stopka Grzegorz 
Published: August 2021

AbstractThe use of asymmetrical disc tools for the mining of hard and very hard rocks is a promising direction for developing mechanical mining methods. A significant obstacle in developing mining methods with the use of asymmetric disc tools is the lack of adequate computational methods. A deep understanding of rock–tool interaction can develop industrial applications of asymmetric disc tools significantly. The fundamental problem in designing work systems with asymmetric disc tools is the lack of adequate analytical models to identify tool loads during the mining process. One reasonable approach is to use computer simulation. The purpose of the research was to develop a simulation model of rock cutting using an asymmetrical disc tool and then evaluate the developed model. In the article, the Discrete-Element Method (DEM) in LS-Dyna was adopted to simulate rock cutting with asymmetrical disc tools. Numerical tests were conducted by pushing the disc into a rock sample at a given distance from the sample edge until the material was detached entirely. Two types of rock samples were used in the simulation tests: concrete and sandstone. The independent variables in the study were the disc diameter and the cut spacing. To validate the simulation model, analogous laboratory tests were carried out. The article presents a comparison of the results of simulation and laboratory tests. The given comparison showed good accordance LS-Dyna model with the experimental studies. The proposed test results can be input data for developing simulation models on a larger scale. Thus, it will be possible to consider the complex kinematics of the dynamics of the rock-mining process with disc tools using the DEM simulation.
Motor and functional outcome of selective dorsal rhizotomy in children with spastic diplegia at 12 and 24 months of follow-up
Authors: Sargut Tarik Alp , Haberl Hannes , Wolter Simone , Tafelski Sascha , van Riesen Anne , Linhard Maijana , Kaindl Angela M. , Thomale Ulrich-Wilhelm , Schulz Matthias 
Published: August 2021

Abstract
Background
Selective dorsal rhizotomy (SDR) in ambulatory children affected by cerebral palsy (CP) is a surgical treatment option to lower spasticity and thereby improve gait and ambulation. The aim of the current study is to investigate the outcome of children with respect to spasticity, muscle strength, and overall function after SDR.

Methods
All children who underwent SDR via a single-level laminotomy in the time period from January 2007 to April 2015 at our center were enrolled in this study. Within a standardized evaluation process, the following was assessed routinely pre-operatively and 12 and 24 months following surgery: extent of spasticity at hip adductors and hamstrings as characterized by the Modified Ashworth Scale (MAS), maximal muscle strength as characterized by the Medical Council Research Scale (MRC), overall function regarding ambulation as characterized by the Gross Motors Function Classification System (GFMCS), and overall function as characterized by the Gross Motor Function Measure (GMFM-88).

Results
Matching sets of pre- and post-operative assessments of the chosen outcome parameters were available for 109 of the 150 children who underwent SDR within the observation period. After 24 months, the MAS scores of hip adductors (n = 59) improved in 71% and 76% of children on the right and left side, respectively. In 20% and 19%, it remained unchanged and worsened in 9% and 5% of children on the right and left side, respectively (p < 0.00625). For hamstrings, the rates for the right and left sides were 81% and 79% improvement, 16% and 16% unchanged, and 4% and 5% worsened, respectively (p < 0.00625). Muscle strength of ankle dorsiflexion and knee extension significantly improved after 24 months. Overall function assessed by GMFM-88 improved significantly by 4% after 12 months (n = 77) and by 7% after 24 months (n = 56, p < 0.0001).

Conclusions
The presented data underlines the benefit of SDR in a pediatric patient collective with bilateral spastic CP. The procedure resulted in an effective and permanent reduction of spasticity and improved overall function without causing relevant weakness of the lower extremities.
Climate change, power, and vulnerabilities in the Peruvian Highlands
Authors: Heikkinen Anna Marjaana 
Published: August 2021

AbstractThe intensifying impacts of climate change pose a serious global threat, particularly for rural populations whose livelihoods are closely tied to natural resources. Yet there is a lack of critical understanding of how asymmetric power dynamics shape the vulnerabilities of such populations under climate change. This article examines the interrelations between smallholders’ climate-related vulnerability experiences and power relations across multiple scales of climate adaptation in the Peruvian Andes, a region susceptible to increasing climatic threats. The analysis draws on a case study conducted in the Mantaro River Valley in Central Peru using qualitative methods: open-ended interviews, participant observation, and document analysis. Findings of the study show that in the context of climate change, the production of vulnerabilities has much to do with larger socio-political structures in which protection of the highland farmers is not prioritized. The impact of the uneven scalar power dynamics in climate adaptation and other overlapping fields of policy have created uneven terms of adaptation among smallholders. This has created marginalization, conflicts, and deepened smallholders’ vulnerabilities under climate change. I argue that to reach a better understanding of the multidimensionality of vulnerabilities, more detailed attention must be paid to place-based climate experiences within context-specific, socio-political processes, and to the ways these are shaped by unequal power relations across multiple scales.
Imaging methods for surgical revascularization in patients with moyamoya disease: an updated review
Authors: Du Lanxin , Jiang Hanyu , Li Jin , Duan Ting , Zhou Chenyun , Yan Feng 
Published: August 2021

AbstractNeuroimaging is crucial in moyamoya disease (MMD) for neurosurgeons, during pre-surgical planning and intraoperative navigation not only to maximize the success rate of surgery, but also to minimize postsurgical neurological deficits in patients. This is a review of recent literatures which updates the clinical use of imaging methods in the morphological and hemodynamic assessment of surgical revascularization in patients with MMD. We aimed to assist surgeons in assessing the status of moyamoya vessels, selecting bypass arteries, and monitoring postoperative cerebral perfusion through the latest imaging technology.
Is prevention of suicide worth less? A comparison of the value per statistical life
Authors: Elin Vimefall , Mattias Persson , Sara Olofsson , Lars Hultkrantz 
Published: August 2021

AbstractThis paper compares the value per statistical life (VSL) in the context of suicide prevention to that of prevention of traffic fatalities. We conducted a contingent valuation survey with questions on willingness to pay (WTP) in both contexts by administering a web questionnaire to 1038 individuals aged 18 to 80. We conjectured that WTP for a given impact on the number of fatalities would be lower for suicide prevention because suicide, at least to some degree, is the result of individuals’ own decisions. However, this hypothesis was not supported by the within- or between-sample estimates of WTP or by responses to direct questions. Hence, no support is provided for the use of a lower valuation of the impact of suicide prevention than for risk-reducing programs in other fields, such as traffic safety. This implies that the same VSL should be used for evaluating suicide prevention interventions and for risk-reducing programs in other policy areas and funds for the prevention of fatalities should be directed to the area with the lowest cost per life saved.
Quality of Life Assessment in Trials of Revascularization for Chronic Stable Angina: Insights from ORBITA and the Implications of Blinding
Authors: Nowbar Alexandra N , Francis Darrel P , Al-Lamee Rasha K 
Published: August 2021

AbstractThe main aims of therapy in chronic stable angina are to reduce the risk of myocardial infarction and death and improve symptoms and quality of life (QoL). Unblinded trials have shown that revascularization does not reduce the risk of myocardial infarction or death but does appear to improve symptoms. However, symptoms are susceptible to the placebo effect which can bias therapies to appear more effective than they are. To assess the true physical impact of a treatment on symptoms, placebo-controlled trials with patients and medical and research teams blinded to treatment allocation are necessary. Symptoms and QoL can be reported directly by the patient or indirectly by the physician. Patient-reported outcome measures in angina trials can include angina frequency, frequency of nitrate use, exercise capacity, and questionnaires such as the Seattle Angina Questionnaire (SAQ) and the generic EuroQOL-5D-5L (EQ-5D-5L) QoL questionnaire. Physician-assessed outcome measures include Canadian Cardiovascular Society Class. The Objective Randomised Blinded Investigation with Optimal Medical Therapy of Angioplasty in Stable Angina (ORBITA) trial was the first blinded placebo-controlled study investigating the role of percutaneous coronary intervention (PCI) in chronic stable angina. The trial showed a smaller than expected and not statistically significant effect of placebo-controlled PCI on the primary endpoint of change in exercise time at 6 weeks follow-up in single-vessel coronary artery disease. There was also no significant placebo-controlled treatment effect of PCI for the prespecified secondary endpoints of SAQ or EQ-5D-5L, although PCI did result in 20% more patients becoming free from angina than placebo in a non-prespecified secondary analysis. ORBITA has demonstrated the need for symptomatic and QoL effects of PCI to be studied using placebo control. Here, we describe ways of measuring QoL, the impact of the unblinded and blinded trials to date, what we have learned from ORBITA, and what is next for this common and complex condition.