bluuebunny/crossref_metadata_2025_split huggingface dataset:
Making a case for the inclusion of refractory and severe mental illness as a sole criterion for Canadians requesting medical assistance in dying (MAiD): a review
Authors: Bahji Anees , Delva Nicholas 
Published: April 2021

BackgroundFollowing several landmark rulings and increasing public support for physician-assisted death, in 2016, Canada became one of a handful of countries legalising medical assistance in dying (MAiD) with Bill C-14. However, the revised Bill C-7 proposes the specific exclusion of MAiD where a mental disorder is the sole underlying medical condition (MAiD MD-SUMC).AimThis review explores how some persons with serious and persistent mental illness (SPMI) could meet sensible and just criteria for MAiD under the Canadian legislative framework.MethodsWe review the proposed Bill C-7 criteria (capacity, voluntariness, irremediability and suffering) as well as the nuances involved in separating a well-reasoned request for assisted suicide from what might be solely a manifestation of a SPMI.FindingsIn this paper, we argue against the absolute exclusion of patients with SPMIs from accessing MAiD. Instead, we propose that in some circumstances, MAiD MD-SUMC may be justifiable while remaining the last resort. Conducting MAiD eligibility assessments removes the need to introduce diagnosis-specific language into MAiD legislation. Competent psychiatric patients who request MAiD should not be treated any differently from other eligible candidates. Many individuals with psychiatric disorders will be incapable of consenting to MAiD. The only ethical option is to assess eligibility for MAiD on an individual basis and include as legitimate candidates those who suffer solely from psychiatric illness who have the decisional capacity to consent to MAiD.
Anticoagulation in COVID-19: current concepts and controversies
Authors: Chandra Atanu , Chakraborty Uddalak , Ghosh Shrestha , Dasgupta Sugata 
Published: April 2021

AbstractRising incidence of thromboembolism secondary to COVID-19 has become a global concern, with several surveys reporting increased mortality rates. Thrombogenic potential of the SARS-CoV-2 virus has been hypothesised to originate from its ability to produce an exaggerated inflammatory response leading to endothelial dysfunction. Anticoagulants have remained the primary modality of treatment of thromboembolism for decades. However, there is no universal consensus regarding the timing, dosage and duration of anticoagulation in COVID-19 as well as need for postdischarge prophylaxis. This article seeks to review the present guidelines and recommendations as well as the ongoing trials on use of anticoagulants in COVID-19, identify discrepancies between all these, and provide a comprehensive strategy regarding usage of these drugs in the current pandemic.
Outcomes of major trauma among patients with chronic kidney disease and receiving dialysis in Nova Scotia: a retrospective analysis
Authors: Pratt Ryan , Erdogan Mete , Green Robert , Clark David , Vinson Amanda , Tennankore Karthik 
Published: April 2021

BackgroundThe risk of death and complications after major trauma in patients with chronic kidney disease (CKD) is higher than in the general population, but whether this association holds true among Canadian trauma patients is unknown.ObjectivesTo characterize patients with CKD/receiving dialysis within a regional major trauma cohort and compare their outcomes with patients without CKD.MethodsAll major traumas requiring hospitalization between 2006 and 2017 were identified from a provincial trauma registry in Nova Scotia, Canada. Trauma patients with stage ≥3 CKD (estimated glomerular filtration rate <60 mL/min/1.73 m2) or receiving dialysis were identified by cross-referencing two regional databases for nephrology clinics and dialysis treatments. The primary outcome was in-hospital mortality; secondary outcomes included hospital/intensive care unit (ICU) length of stay (LOS) and ventilator-days. Cox regression was used to adjust for the effects of patient characteristics on in-hospital mortality.ResultsIn total, 6237 trauma patients were identified, of whom 4997 lived within the regional nephrology catchment area. CKD/dialysis trauma patients (n=101; 28 on dialysis) were older than patients without CKD (n=4896), with higher rates of hypertension, diabetes, and cardiovascular disease, and had increased risk of in-hospital mortality (31% vs 11%, p<0.001). No differences were observed in injury severity, ICU LOS, or ventilator-days. After adjustment for age, sex, and injury severity, the HR for in-hospital mortality was 1.90 (95% CI 1.33 to 2.70) for CKD/dialysis compared with patients without CKD.ConclusionIndependent of injury severity, patients without CKD/dialysis have significantly increased risk of in-hospital mortality after major trauma.
Prehospital shock index outperforms hypotension alone in predicting significant injury in trauma patients
Authors: Kheirbek Tareq , Martin Thomas J , Cao Jessica , Hall Benjamin M , Lueckel Stephanie , Adams Charles A 
Published: April 2021

BackgroundThe American College of Surgeons Resources for Optimal Care of the Injured Patient recommends using hypotension, defined as systolic blood pressure ≤90 mm Hg, as an indicator of a full team trauma activation. We hypothesized that an elevated shock index (SI) predicts significant traumatic injuries better than hypotension alone.MethodsThis is a retrospective cohort study analyzing full team trauma activations between February 2018 and January 2020, excluding transfers and those who had missing values for prehospital blood pressure or heart rate. We reviewed patients’ demographics, prehospital and emergency department vitals, injury pattern, need for operation, and clinical outcomes. The primary outcome was rate of significant injury defined as identified injured liver, spleen, or kidney, pelvis fracture, long bone fracture, significant extremity soft tissue damage, hemothorax, or pneumothorax.ResultsAmong 544 patients, 82 (15.1%) had prehospital hypotension and 492 had normal blood pressure. Of the patients with prehospital hypotension, 34 (41.5%) had a significant injury. There was no difference in age, gender, medical history, or injury pattern between the two groups. There was no difference between the two groups in rate of serious injury (41.5% vs. 46.1%, NS), need for emergent operation (31.7% vs. 28.1%, NS) or death (20.7% vs. 18.8%, NS). On the other hand, SI ≥1 was associated with increased rate of serious injury (54.6% vs. 43.4%, p=0.04). On a logistic regression analysis, prehospital hypotension was not associated with significant injury or need for emergent operation (OR 0.83, 95% CI 0.51 to 1.33 and OR 1.32, 95% CI 0.79 to 2.25, respectively). SI ≥1 was associated with both increased odds of significant injury and need for emergent operation (OR 1.57, 95% CI 1.01 to 2.44 and OR 1.64, 95% CI 1.01 to 2.66).DiscussionSI was a better indicator and could replace hypotension to better categorize and triage patients in need of higher level of care.Level of evidencePrognostic and epidemiologic, level III.
The influence of age, sex and cardiorespiratory fitness on maximal fat oxidation rate
Authors: Frandsen J. , Amaro-Gahete F.J. , Landgrebe A. , Dela F. , Ruiz J.R. , Helge J.W. , Larsen S. 
Published: April 2021

Fat oxidation decreases with age, yet no studies have previously investigated if aging affects the maximal fat oxidation rate (MFO) during exercise in men and women differently. We hypothesized that increased age would be associated with a decline in MFO and this would be more pronounced in women due to menopause, compared with men. In this cross-sectional study design, 435 (247/188, male/female) subjects of varying ages performed a DXA scan, a submaximal graded exercise test and a maximal oxygen uptake test, to measure MFO and cardiorespiratory fitness (CRF) by indirect calorimetry. Subjects were stratified into 12 groups according to sex (male/female), age (<45, 45–55 and >55 years), CRF (below average and above average). Women aged <45 years had a higher MFO relative to fat free mass (FFM) (mg/min/kg) compared with men, regardless of CRF. However, there were no differences in MFO (mg/min/kg FFM) between men and women, in the groups aged between 45–55 and >55 years. In summary, we found that women aged <45 years display a higher MFO (mg/min/kg FFM) compared with men and that this sexual divergence is abolished after the age of 45 years. Novelty: Maximal fat oxidation rate is higher in young women compared with men. This sex-related difference is attenuated after the age of 45 years. Cardiorespiratory fitness does not influence this sex-related difference.
Zeros of amplitude in the associated production of photon and leptoquark at $$\varvec{e}$$-$$\varvec{p}$$ collider
Authors: Bandyopadhyay Priyotosh , Dutta Saunak , Karan Anirban 
Published: April 2021

AbstractThough various extensions of the Standard Model with higher gauge group predict the existence of leptoquarks, none of them has been observed yet at any of the colliders. In this paper, we study the prospect of several past and future $$e$$
e
-$$p$$
p
colliders like HERA, LHeC and FCC-he to detect them through radiation amplitude zero. We find that the leptoquarks showing zeros in the tree-level single-photon amplitudes at $$e$$
e
-$$p$$
p
collider lie within the complementary set of those exhibiting zeros at e-$$\gamma $$
γ
collider. We present a PYTHIA-based analysis for HERA, LHeC and FCC-he (run II) to detect the leptoquarks with masses 70 GeV, 900 GeV and 1.5 TeV (2.0 TeV) respectively through radiation amplitude zero.
Roots of quantum computing supremacy: superposition, entanglement, or complementarity?
Authors: Khrennikov Andrei 
Published: April 2021

AbstractThe recent claim of Google to have brought forth a breakthrough in quantum computing represents a major impetus to further analyze the foundations for any claims of superiority regarding quantum algorithms. This note attempts to present a conceptual step in this direction. I start with a critical analysis of what is commonly referred to as entanglement and quantum nonlocality and whether or not these concepts may be the basis of quantum superiority. Bell-type experiments are then interpreted as statistical tests of Bohr’s principle of complementarity (PCOM), which is, thus, given a foothold within the area of quantum informatics and computation. PCOM implies (by its connection to probability) that probabilistic algorithms may proceed without the knowledge of joint probability distributions (jpds). The computation of jpds is exponentially time consuming. Consequently, classical probabilistic algorithms, involving the computation of jpds for n random variables, can be outperformed by quantum algorithms (for large values of n). Quantum probability theory (QPT) modifies the classical formula for the total probability (FTP). Inference based on the quantum version of FTP leads to a constructive interference that increases the probability of some events and reduces that of others. The physical realization of this probabilistic advantage is based on the discreteness of quantum phenomena (as opposed to the continuity of classical phenomena).
The cryogenic control system of BEPCII
Authors: Li Gang , Ye Rui , Sang Mingjing , Li Shaopeng , Zhang Zhuo , Zhang Jiehao , Han Ruixiong , Lei Ge , Ge Rui 
Published: April 2021

AbstractThe BEPCII project is for upgrading the Beijing Electron Positron Collider to reach a higher luminosity. The cryogenic system has been firstly designed and deployed in BEPCII, which provides cooling capacity for SRF cavities, SCQ and SSM. The cryogenic control system consists of Siemens PLC for the refrigerator control and “PLC + IOC” for superconducting device control. The BEPCII machine commissioning with beam started in October 2006. This paper describes the design and the development of the cryogenic control system.
A high-sensitivity dual-sample synchronous detection photonic crystal fiber sensor
Authors: Bing Pibin , Wu Guifang , Li Zhongyang , Yuan Sheng , Zhang Hongtao , Xu Jua , Yao Jianquan 
Published: April 2021

The photonic crystal fiber (PCF) sensor based on surface plasmon resonance (SPR) technology has flexibility in birefringence, negative dispersion, effective area and nonlinearity and has become a widely studied new fiber. However, there are many problems in the practical application of the sensor, such as complex structure design, not easy to prepare, the low sensitivity of sensing detection, narrow range of refractive index detection of analytes, which greatly limits the application range and functions of PCF sensors. To solve the above problems, this paper adopts a structure with a longer vertical distance between the D-shaped large air hole channel and the core. The energy of the core conduction mode is better limited by the cladding to transmit in the core, and the plasma mode is enhanced, which can effectively increase the wavelength sensitivity. In this paper, the hexagonal double-clad air hole structure and the D-type structure are combined to ensure a simple structure and facilitate manufacturing and production, while the wavelength sensitivity is also greatly improved. The wavelength sensitivity of the dual sample channel can reach up to 16200 nm/RIU and 15800 nm/RIU, which has broad application prospects in the field of high-sensitivity detection.
Anthropometric Markers and Iron Status of 6–12-Year-Old Thai Children: Associations and Predictors
Authors: Suteerojntrakool Orapa , Khongcharoensombat Tharida , Chomtho Sirinuch , Bongsebandhu-phubhakdi Chansuda , Tempark Therdpong , Fewtrell Mary 
Published: April 2021

Introduction. Obesity may be associated with poor iron status. The objective of this study was to investigate the association between different indices of iron status and anthropometric measurements in Thai children. Materials and Methods. Anthropometry (weight, height, waist circumference (WC), and body composition assessed by bioelectrical impedance analysis) and iron indices were measured in 336 Thai children aged 6–12 years. Iron deficiency (ID) was defined using two or more of the following: (1) %transferrin saturation (%Tsat) < 16%; (2) serum ferritin (SF) < 15 μg/mL; and (3) soluble transferrin receptor (sTfR) > 5 mg/L. Iron deficiency anaemia (IDA) was defined as haemoglobin < WHO age cutoff combined with ID. Overweight and obesity were defined as body mass index (BMI) standard deviation score (SDS) ≥ +1 SDS or +2 SDS, respectively (WHO growth reference). Results. BMI SDS was significantly positively correlated with sTfR and SF (sTfR, r: 0.209,

p

< 0.001; SF, r: 0.214,

p

< 0.001) and negatively correlated with %Tsat (r: −0.132,

p

= 0.013). Correlations between WC SDS and %fat mass and each iron marker were similar. The percentage with low SF was significantly lower than that using other individual markers. ID prevalence was not significantly different between normal-weight and overweight/obesity groups although a significantly higher proportion of overweight/obese children had sTfR >5 mg/L. Puberty and menarche were significant predictors of ID (puberty adjusted OR: 2.20, 95% CI: 0.43, 11.25; menarche adjusted OR: 6.11, 95% CI: 1.21, 30.94). Conclusion. Greater adiposity was associated with poorer iron status. However, SF may not be a good indicator of iron status in Thai children, particularly in those who are overweight/obese, whereas sTfR merits further investigation.
Can Cost-effectiveness Analysis Inform Genotype-Guided Aspirin Use for Primary Colorectal Cancer Prevention?
Authors: Biltaji Eman , Walker Brandon , Au Trang H. , Rivers Zachary , Ose Jennifer , Li Christopher I. , Brixner Diana I. , Stenehjem David D. , Ulrich Cornelia M. 
Published: April 2021

Abstract

Background:
Inherited genetic variants can modify the cancer-chemopreventive effect of aspirin. We evaluated the clinical and economic value of genotype-guided aspirin use for colorectal cancer chemoprevention in average-risk individuals.

Methods:
A decision analytical model compared genotype-guided aspirin use versus no genetic testing, no aspirin. The model simulated 100,000 adults ≥50 years of age with average colorectal cancer and cardiovascular disease risk. Low-dose aspirin daily starting at age 50 years was recommended only for those with a genetic test result indicating a greater reduction in colorectal cancer risk with aspirin use. The primary outcomes were quality-adjusted life-years (QALY), costs, and incremental cost-effectiveness ratio (ICER).

Results:
The mean cost of using genotype-guided aspirin was $187,109 with 19.922 mean QALYs compared with $186,464 with 19.912 QALYs for no genetic testing, no aspirin. Genotype-guided aspirin yielded an ICER of $66,243 per QALY gained, and was cost-effective in 58% of simulations at the $100,000 willingness-to-pay threshold. Genotype-guided aspirin was associated with 1,461 fewer polyps developed, 510 fewer colorectal cancer cases, and 181 fewer colorectal cancer-related deaths. This strategy prevented 1,078 myocardial infarctions with 1,430 gastrointestinal bleeding events, and 323 intracranial hemorrhage cases compared with no genetic testing, no aspirin.

Conclusions:
Genotype-guided aspirin use for colorectal cancer chemoprevention may offer a cost-effective approach for the future management of average-risk individuals.

Impact:
A genotype-guided aspirin strategy may prevent colorectal cancer, colorectal cancer-related deaths, and myocardial infarctions, while minimizing bleeding adverse events. This model establishes a framework for genetically-guided aspirin use for targeted chemoprevention of colorectal cancer with application toward commercial testing in this population.
Dose–Response Association between Adiposity and Liver Cancer Incidence: A Prospective Cohort Study among Non-Smoking and Non–Alcohol-Drinking Chinese Women
Authors: Li Zhuo-Ying , Li Hong-Lan , Ji Xiao-Wei , Shen Qiu-Ming , Wang Jing , Tan Yu-Ting , Xiang Yong-Bing 
Published: April 2021

AbstractBackground:Based on a population with very low prevalence of smoking and alcohol drinking, we examined the associations between overall obesity and fat distribution in middle age, obesity in early adulthood, and adult weight gain with the risk of liver cancer incidence.Methods:The associations between body mass index (BMI) at study enrollment and at age 20, waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), adult weight gain, and annual average weight gain with the risk of liver cancer were estimated using Cox regression models. Multivariable-adjusted HRs and 95% confidence intervals (CIs) were calculated.Results:After a mean follow-up time of 17.5 years, 241 liver cancer cases were identified from 69,296 participants. The HRs for per 5-kg/m2 increment of BMI, per 10-cm increment of WC and HC, and per 0.1-unit increment of WHtR in middle age were 1.29 (95% CI, 1.07–1.57), 1.23 (95% CI, 1.05–1.43), 1.30 (95% CI, 1.10–1.55), and 1.37 (95% CI, 1.07–1.75), respectively. The HRs for per 5-kg increment of absolute adult weight gain and per 0.5-kg/year increment of annual average weight gain were 1.15 (95% CI, 1.06–1.25) and 1.44 (95% CI, 1.08–1.92).Conclusions:Overall and abdominal obesity in middle age and weight gain through adulthood were positively associated with liver cancer risk among non-smoking and non–alcohol-drinking women.Impact:Based on a cohort of non-smoking and non–alcohol-drinking women, the current study confirmed the association between obesity in middle age and increased liver cancer risk and suggested weight gain through adulthood as a risk factor for liver cancer.
The Evolving Epidemiology of Nasopharyngeal Carcinoma
Authors: Chang Ellen T. , Ye Weimin , Zeng Yi-Xin , Adami Hans-Olov 
Published: April 2021

AbstractBackground:The epidemiology of nasopharyngeal carcinoma (NPC) has long been a source of fascination due to the malignancy's striking geographic distribution, the involvement of the oncogenic Epstein–Barr virus (EBV), the unique association with intake of Chinese-style salt-preserved fish, and etiologic heterogeneity by histologic subtype.Methods:This review summarizes the current epidemiologic literature on NPC, highlighting recent results from our population-based case–control study in southern China.Results:Findings from our case–control study provide new insight into the epidemiology of NPC, including a diminished role of Chinese-style salt-preserved fish, a profound impact of EBV genetic sequence variation, modest positive associations with passive smoking and household air pollution, and possible effects of oral health and the oral microbiome. Recent findings from other studies include a protective association with infectious mononucleosis, suggesting a causal role of early EBV infection; familial risk conferred by shared genetic variation in the host antibody-mediated immune response to EBV infection; and an unclear association with occupational exposure to formaldehyde.Conclusions:To shed further light on the interplay of environmental, genetic, and viral causes of NPC, large pooled studies must accumulate sufficient cases with detailed exposure data.Impact:New epidemiologic findings have reshaped the causal model for NPC.
Use of Medications for Treating Anxiety or Depression among Testicular Cancer Survivors: A Multi-Institutional Study
Authors: ArdeshirRouhaniFard Shirin , Dinh Paul C. , Monahan Patrick O. , Fossa Sophie D. , Huddart Robert , Fung Chunkit , Song Yiqing , Feldman Darren R. , Hamilton Robert J. , Vaughn David J. , Martin Neil E. , Kollmannsberger Christian , Einhorn Lawrence , Kroenke Kurt , Travis Lois B. 
Published: April 2021

Abstract

Background:
This study examined sociodemographic factors, cisplatin-related adverse health outcomes (AHO), and cumulative burden of morbidity (CBMPt) scores associated with medication use for anxiety and/or depression in testicular cancer survivors (TCS).

Methods:
A total of 1,802 TCS who completed cisplatin-based chemotherapy ≥12 months previously completed questionnaires regarding sociodemographic features and cisplatin-related AHOs [hearing impairment, tinnitus, peripheral sensory neuropathy (PSN), and kidney disease]. A CBMPt score encompassed the number and severity of cisplatin-related AHOs. Multivariable logistic regression models assessed the relationship of individual AHOs and CBMPt with medication use for anxiety and/or depression.

Results:
A total of 151 TCS (8.4%) used medications for anxiety and/or depression. No cisplatin-related AHOs were reported by 511 (28.4%) participants, whereas 622 (34.5%), 334 (18.5%), 287 (15.9%), and 48 (2.7%), respectively, had very low, low, medium, and high CBMPt scores. In the multivariable model, higher CBMPt scores were significantly associated with medication use for anxiety and/or depression (P &lt; 0.0001). In addition, tinnitus (P = 0.0009), PSN (P = 0.02), and having health insurance (P = 0.05) were significantly associated with greater use of these medications, whereas being employed (P = 0.0005) and vigorous physical activity (P = 0.01) were significantly associated with diminished use.

Conclusions:
TCS with higher CBMPt scores had a higher probability of using medications for anxiety and/or depression, and conversely, those who were employed and physically active tended to have reduced use of these medications.

Impact:
Healthcare providers should encourage TCS to increase physical activity to improve both physical and mental health. Rehabilitation programs should assess work-related skills and provide career development counseling/training.