bluuebunny/crossref_metadata_2025_split huggingface dataset:
SILAR Deposition of Metal Oxide Nanostructured Films
Authors: Ratnayake Samantha Prabath , Ren Jiawen , Colusso Elena , Guglielmi Massimo , Martucci Alessandro , Della Gaspera Enrico 
Published: July 2021

AbstractMethods for the fabrication of thin films with well controlled structure and properties are of great importance for the development of functional devices for a large range of applications. SILAR, the acronym for Successive Ionic Layer Adsorption and Reaction, is an evolution and combination of two other deposition methods, the Atomic Layer Deposition and Chemical Bath Deposition. Due to a relative simplicity and low cost, this method has gained increasing interest in the scientific community. There are, however, several aspects related to the influence of the many parameters involved, which deserve further deepening. In this review article, the basis of the method, its application to the fabrication of thin films, the importance of experimental parameters, and some recent advances in the application of oxide films are reviewed. At first the fundamental theoretical bases and experimental concepts of SILAR are discussed. Then, the fabrication of chalcogenides and metal oxides is reviewed, with special emphasis to metal oxides, trying to extract general information on the effect of experimental parameters on structural, morphological and functional properties. Finally, recent advances in the application of oxide films prepared by SILAR are described, focusing on supercapacitors, transparent electrodes, solar cells, and photoelectrochemical devices.
Iodine Immobilized Metal–Organic Framework for NIR‐Triggered Antibacterial Therapy on Orthopedic Implants
Authors: Teng Wangsiyuan , Zhang Zengjie , Wang Yikai , Ye Yuxiao , Yinwang Eloy , Liu An , Zhou Xingzhi , Xu Jianxiang , Zhou Chengwei , Sun Hangxiang , Wang Fangqian , Zhang Lingling , Cheng Chongguang , Lin Peng , Wu Yan , Gou Zhongru , Yu Xiaohua , Ye Zhaoming 
Published: July 2021

AbstractIodine has been known as an effective disinfectant with broad‐spectrum antimicrobial potency yet without drug resistance risk when used in clinic. However, the exploration of iodine for antibacterial therapy in orthopedics remains sparse due to its volatile nature and poor solubility. Herein, leveraging the superior absorption capability of metal–organic frameworks (MOFs) and their inherent photocatalytic properties, iodine‐loaded MOF surface is presented to realize responsive iodine release along with intracellular reactive oxygen species(ROS) oxidation under near‐infrared (NIR) exposure to achieve synergistic antibacterial effect. Iodine is successfully loaded using vapor deposition process onto zeolitic imidazolate framework‐8(ZIF‐8), which is immobilized onto micro arc oxidized titanium via a hydrothermal approach. The combination of NIR‐triggered iodine release and ZIF‐8 mediated ROS oxidative stress substantially augments the antibacterial efficacy of this approach both in vitro and in vivo. Furthermore, this composite coating also supported osteogenic differentiation of bone marrow stromal cells, as well as improved osseointegration of coated implants using an intramedullary rat model, suggesting improvement of antibacterial efficacy does not impair osteogenic potential of the implants. Altogether, immobilization of iodine via MOF on orthopedic implants with synergistic antibacterial effect can be a promising strategy to combat bacterial infections.
Total joint replacement surgeries: Making the case for a public–private partnership in Hong Kong
Authors: Ho Margaret K. 
Published: July 2021

AbstractWith the increased demand for health services given the growing ageing population and the reduced volume of elective operations performed due to the COVID‐19 pandemic, a public–private partnership for total joint replacement surgeries in Hong Kong may be a solution to these challenges. By contracting out a proportion of operations to the private sector, this can relieve pressure on the public system and allow for progression towards allocative efficiency. The public sector would benefit from a reduced case load while the private sector may enjoy increased profits from a larger volume of operations. This reform may also reduce long waiting times for surgeries, thus benefitting patients and health outcomes. The inclusion of price controls and government subsidies ensures that the reform remains equitable. As Hong Kong has had success with similar initiatives, this partnership would be a practical approach to address some of the city's most pressing health issues today.
Access to genetic testing for rare diseases: Existing gaps in public‐facing information
Authors: Robillard Julie M. , Feng Tanya L. , Kabacińska Katarzyna 
Published: July 2021

AbstractGenetic testing plays an increasingly important role in the diagnosis and potential treatment of inherited and rare conditions, such as aniridia—a disease that leads to abnormal eye development, as well as in health research on these conditions. As genetic testing is increasingly sought for accurate and early diagnosis of rare genetic disorders and in the context of direct‐to‐consumer genomics, it is critical to examine the public‐facing information about access to these services and reimbursement policies. We conducted a targeted policy and public‐facing resource search. Our analysis of resources available for the patient community revealed that there is very little practical guidance available about access and reimbursement for genetic testing for rare diseases. Greater clarity in public‐facing resources about genetic testing would be beneficial to the patient community as it would promote informed choices about the procedure, mitigate potential harms associated with lack of information and enable patient engagement in their own health care.
Anticipating Policy, Orienting Services, Celebrating Provision: Reflecting on Scotland’s PrEP Journey
Authors: Young Ingrid 
Published: July 2021

AbstractPrEP in Scotland came with great expectation and celebration. As the first country in the UK to offer PrEP through the National Health Service (NHS), Scotland was heralded as a leader in HIV prevention. This chapter asks: how has the anticipation of PrEP shaped provision and use within the health system; how does the emergent and ongoing orientation of PrEP towards specific risk practices affect awareness, access and use, but also wider narratives of prevention, inequalities and ‘progress’; and, what kinds of biosexual citizens does it demand and produce? The chapter explores how the implementation of PrEP and the specific nature of its roll-out contribute to an orientation towards certain (gendered) PrEP users and PrEP use. It considers how the anticipation of PrEP as a biotechnology for particular risk practices, bodies and communities shapes promissory HIV prevention futures and determines what success and ‘celebration’ could be.
Interpretation of Network Sovereignty
Authors: Li Hui , Yang Xin 
Published: July 2021

AbstractIn recent years, with the integration of the Internet and various economic and social fields, the security situation in cyberspace has been changing rapidly. There are more and more network games at the national level and the network attack and defense have become more intense. Network sovereignty has become one of sovereignty that all states are striving for. Cyber war against national targets has emerged and will not abate. Major countries have successively set up cyberspace forces. These facts have demonstrated the existence of a new frontier for humanity, national interests, and digital sovereignty in cyberspace, and demonstrated the absence of international rules or laws that effectively coordinate the management of this space. The chaos in the online media during the US presidential election in 2020, in which the incumbent US president has been banned from several public accounts by major online social media, shows that there is still a long way to go in terms of citizens’ digital human rights and the reasonable and orderly legislative and judicial administration of domestic cyberspace management. All of these topics are discussed in detail in this chapter.
Prototype of Sovereignty Network and Application of Private Network Based on MIN
Authors: Li Hui , Yang Xin 
Published: July 2021

AbstractMulti-Identifier Network (MIN) is compatible with IP network, and supports naturally and gradually de-IP, which will be promoted by users and the market for its performance gains rather than by compulsively. It is a predictable circumstance that the IP network may still be mainstream at United States of American in the future. But other countries will move away from IP to MIN in order to safeguard their sovereignty over cyberspace, and the connectivity between them and IP network are guaranteed through MIN. In other words, IP network will become the internal network of the United States, while other countries will constitute a multilateral governance network system based on MIN. In brief, the applications scenarios of Co-governed Sovereignty Network based on MIN could be classified into three scales: the small-scale scenarios such as high-security private networks for enterprises, industries, and government departments; the medium-scale scenarios of industrial Internet, private network of Internet of vehicles and smart city; the United Nations of Cyberspace: raplacing the current IP network with the large-scale high-security cyberspace for multilateral condominium and sovereign autonomy.
Komorbiditäten bei Typ-1-Diabetes im Kindes- und Jugendalter
Authors: Fröhlich-Reiterer Elke 
Published: July 2021

ZusammenfassungTyp-1-Diabetes (T1D) ist eine der häufigsten Stoffwechselerkrankungen im Kindes- und Jugendalter. Komorbiditäten beim T1D können in physische und psychische unterteilt werden. Dieser Beitrag beschäftigt sich mit physischen/organspezifischen Komorbiditäten. Die Assoziation zwischen T1D und anderen Autoimmunerkrankungen ist gut bekannt. Die beiden häufigsten assoziierten Autoimmunerkrankungen bei Kindern und Jugendlichen mit T1D sind die Autoimmunthyreoiditis und die Zöliakie. Da diese oft asymptomatisch sind, sollen regelmäßige Screeninguntersuchungen auf eine assoziierte Autoimmunthyreoiditis und Zöliakie durchgeführt werden. Weitere Komorbiditäten können die Haut, das Gewicht und Längenwachstum sowie die Knochen und Gelenke betreffen. Regelmäßige Messungen von Körperlänge und -gewicht (Perzentilen), Blutdruck (Perzentilen), die Beurteilung der Pubertätsentwicklung (Tanner-Stadien) sowie die regelmäßige Überprüfung der Haut, hier v. a. die Injektions‑/Katheter- und Sensor-Stellen, sollen fixer Bestandteil der Langzeitbetreuung von Kindern und Jugendlichen mit T1D sein.
How Many Inflections are There in the Lyapunov Spectrum?
Authors: Jenkinson O. , Pollicott M. , Vytnova P. 
Published: July 2021

AbstractIommi and Kiwi (J Stat Phys 135:535–546, 2009) showed that the Lyapunov spectrum of an expanding map need not be concave, and posed various problems concerning the possible number of inflection points. In this paper we answer a conjecture in Iommi and Kiwi (2009) by proving that the Lyapunov spectrum of a two branch piecewise linear map has at most two points of inflection. We then answer a question in Iommi and Kiwi (2009) by proving that there exist finite branch piecewise linear maps whose Lyapunov spectra have arbitrarily many points of inflection. This approach is used to exhibit a countable branch piecewise linear map whose Lyapunov spectrum has infinitely many points of inflection.
Complementary use of the Ecosystem Service Concept and Multi-criteria Decision Analysis in Water Management
Authors: Marttunen Mika , Mustajoki Jyri , Lehtoranta Virpi , Saarikoski Heli 
Published: July 2021

AbstractThe ecosystem service (ES) concept has increasingly been applied in environmental planning, while there are several decades of experience in applying multi-criteria decision analysis (MCDA) in complex planning situations. The aim of this article is to assess how the ES concept has been used in water management projects together with MCDA and to examine the experiences gained and make recommendations to overcome any identified challenges. Our conclusions are based on a systematic analysis of 23 articles that were selected among 206 articles focused on water-related studies using, for example, the terms multi-criteria and ecosystem services in the title, abstract or keywords. Here, we explore (i) at what level of detail ESs are included in the decision hierarchy, (ii) the pros and cons of the complementary use of the two approaches, and (iii) how the potential challenges related to the use of MCDA, such as the large number of criteria, double-counting, or assigning criteria weights, are addressed in the selected cases. The results reveal large differences between the case studies. It is shown that only a few case studies used ES categories to classify criteria in the decision hierarchy, that these cases included different numbers of ES criteria and non-ES criteria, and that most case studies elicited stakeholder preferences in MCDA. Although the paper focuses on water management projects, the conclusions regarding the advantages and pitfalls of the complementary use of the methods, as well as our recommendations, are also applicable to other environmental management contexts.
Cross-platform transcriptional profiling identifies common and distinct molecular pathologies in Lewy body diseases
Authors: Feleke Rahel , Reynolds Regina H. , Smith Amy M. , Tilley Bension , Taliun Sarah A. Gagliano , Hardy John , Matthews Paul M. , Gentleman Steve , Owen David R. , Johnson Michael R. , Srivastava Prashant K. , Ryten Mina 
Published: July 2021

AbstractParkinson’s disease (PD), Parkinson’s disease with dementia (PDD) and dementia with Lewy bodies (DLB) are three clinically, genetically and neuropathologically overlapping neurodegenerative diseases collectively known as the Lewy body diseases (LBDs). A variety of molecular mechanisms have been implicated in PD pathogenesis, but the mechanisms underlying PDD and DLB remain largely unknown, a knowledge gap that presents an impediment to the discovery of disease-modifying therapies. Transcriptomic profiling can contribute to addressing this gap, but remains limited in the LBDs. Here, we applied paired bulk-tissue and single-nucleus RNA-sequencing to anterior cingulate cortex samples derived from 28 individuals, including healthy controls, PD, PDD and DLB cases (n = 7 per group), to transcriptomically profile the LBDs. Using this approach, we (i) found transcriptional alterations in multiple cell types across the LBDs; (ii) discovered evidence for widespread dysregulation of RNA splicing, particularly in PDD and DLB; (iii) identified potential splicing factors, with links to other dementia-related neurodegenerative diseases, coordinating this dysregulation; and (iv) identified transcriptomic commonalities and distinctions between the LBDs that inform understanding of the relationships between these three clinical disorders. Together, these findings have important implications for the design of RNA-targeted therapies for these diseases and highlight a potential molecular “window” of therapeutic opportunity between the initial onset of PD and subsequent development of Lewy body dementia.
A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies
Authors: Hartlage-Rübsamen Maike , Bluhm Alexandra , Moceri Sandra , Machner Lisa , Köppen Janett , Schenk Mathias , Hilbrich Isabel , Holzer Max , Weidenfeller Martin , Richter Franziska , Coras Roland , Serrano Geidy E. , Beach Thomas G. , Schilling Stephan , von Hörsten Stephan , Xiang Wei , Schulze Anja , Roßner Steffen 
Published: July 2021

AbstractParkinson’s disease (PD) is a progressive neurodegenerative disorder that is neuropathologically characterized by degeneration of dopaminergic neurons of the substantia nigra (SN) and formation of Lewy bodies and Lewy neurites composed of aggregated α-synuclein. Proteolysis of α-synuclein by matrix metalloproteinases was shown to facilitate its aggregation and to affect cell viability. One of the proteolysed fragments, Gln79-α-synuclein, possesses a glutamine residue at its N-terminus. We argue that glutaminyl cyclase (QC) may catalyze the pyroglutamate (pGlu)79-α-synuclein formation and, thereby, contribute to enhanced aggregation and compromised degradation of α-synuclein in human synucleinopathies. Here, the kinetic characteristics of Gln79-α-synuclein conversion into the pGlu-form by QC are shown using enzymatic assays and mass spectrometry. Thioflavin T assays and electron microscopy demonstrated a decreased potential of pGlu79-α-synuclein to form fibrils. However, size exclusion chromatography and cell viability assays revealed an increased propensity of pGlu79-α-synuclein to form oligomeric aggregates with high neurotoxicity. In brains of wild-type mice, QC and α-synuclein were co-expressed by dopaminergic SN neurons. Using a specific antibody against the pGlu-modified neo-epitope of α-synuclein, pGlu79-α-synuclein aggregates were detected in association with QC in brains of two transgenic mouse lines with human α-synuclein overexpression. In human brain samples of PD and dementia with Lewy body subjects, pGlu79-α-synuclein was shown to be present in SN neurons, in a number of Lewy bodies and in dystrophic neurites. Importantly, there was a spatial co-occurrence of pGlu79-α-synuclein with the enzyme QC in the human SN complex and a defined association of QC with neuropathological structures. We conclude that QC catalyzes the formation of oligomer-prone pGlu79-α-synuclein in human synucleinopathies, which may—in analogy to pGlu-Aβ peptides in Alzheimer’s disease—act as a seed for pathogenic protein aggregation.
Correlation between functional outcome and the SAMEO-ATO framework
Authors: Pontillo Vito , Damiani Marialessia , Graziano Giusi , Quaranta Nicola 
Published: July 2021

Abstract
Purpose
To evaluate the recently proposed SAMEO-ATO framework for middle ear and mastoid surgery, by correlating it with the functional outcome in a large cohort of patients operated for middle ear and mastoid cholesteatoma in a tertiary referral center.

Methods
We retrospectively included all surgeries for middle ear and mastoid cholesteatoma undergone in our Department between January 2009 and December 2014, by excluding revision surgeries, congenital and petrous bone cholesteatoma. All surgeries were classified according to the SAMEO-ATO framework. The post-operative air bone gap (ABG) was calculated and chosen as benchmark parameter for the correlation analysis.

Results
282 consecutive surgeries for middle ear and mastoid cholesteatoma were released in the study period on a total of 273 patients, with a mean age of 41.2 years. All patients were followed for an average period of 55.3 months. 54% of patients underwent M2c mastoidectomy (Canal Wall Down, CWD), while the remaining underwent Canal Wall Up (CWU) procedures, being M1b2a mastoidectomy the most common one (33%). Mean pre-operative and post-operative ABGs were 29.2 and 23.5 dB, with a significant improvement (p < 0.0001). ‘Mastoidectomy’ and ‘Ossicular reconstruction’ parameters of SAMEO-ATO showed significant association with postoperative ABG, with smaller residual gaps for the classes Mx and On, and worse hearing results for M3a and Ox.

Conclusion
Our results show the utility of SAMEO-ATO framework, and in particular of ‘M’ (Mastoidectomy) and ‘O’ (Ossicular reconstruction) parameters, in predicting the hearing outcome.
Missing lawsonite and aragonite found: P–T and fluid composition in meta-marls from the Combin Zone (Western Alps)
Authors: Manzotti Paola , Ballèvre Michel , Pitra Pavel , Schiavi Federica 
Published: July 2021

AbstractWe report the first findings of several occurrences of lawsonite and metamorphic aragonite in the meta-sediments from the Combin Zone (Piemonte–Liguria ocean, Western Alps), where the early blueschist-facies episode is poorly documented. New field and metamorphic data (thermodynamic modelling and Raman spectroscopy on carbonaceous material) are used to elucidate the P–T evolution and fluid composition of the Combin Zone and investigate the lawsonite growth and breakdown reactions. Two tectonometamorphic units have been identified within the Combin Zone with distinct geometry, lithological content and P–T conditions. In the higher grade unit, metamorphic aragonite occurs as inclusions in titanite. Lawsonite and garnet were stable at peak P–T conditions (~ 16–17 kbar and 460–480 °C) at very low X(CO2) values. Lawsonite is systematically pseudomorphed, but preserves hourglass zoning or internal fabric associated with the prograde ductile deformation. The lower grade unit (~ 8 ± 1 kbar ~ 370–400 °C) is discontinuously exposed along the western base of the continental Dent Blanche nappe and records P–T conditions similar to those recorded by the Dent Blanche nappe. A metamorphic discontinuity is, therefore, documented between the largest part of the Combin Zone on the one hand, and the Dent Blanche nappe on the other hand. The discovery of lawsonite and metamorphic aragonite allows a better understanding of the large-scale metamorphic structure of the Western Alps.
Application of biomarkers in the diagnosis of uncertain samples of core needle biopsy of thyroid nodules
Authors: Xiong Yan , Li Xin , Liang Li , Li Dong , Yan Limin , Li Xueying , Di Jiting , Li Ting 
Published: July 2021

AbstractCore needle biopsy (CNB) is now more frequently used for the preoperative diagnosis of thyroid nodules. Based on morphology alone, 5–20% of CNB samples cannot be determined as malignant or benign. Compared to fine-needle biopsy (FNB), samples collected by CNB are more accessible for various tests. Therefore, studying biomarkers’ application in distinguishing uncertain CNB samples of thyroid nodules is a practical need. Patients of thyroid nodules with both CNB and matched resected specimens were reviewed. Cases classified as indeterminate lesions, follicular neoplasms, and suspicious for malignancy were retrieved. All CNB samples were stained by immunohistochemistry (IHC) using antibodies against CK19, galectin-3, HBME-1, and CD56 and detected by next-generation sequencing (NGS) using an OncoAim® thyroid cancer multigene assay kit (Singlera Genomics) that detected 26 genes. Taking the resected specimens’ classification as the gold standard, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), accuracy of a single biomarker, and various combinations for discriminating malignancy from benignity were calculated. The sensitivity, specificity, PPV, NPV, and accuracy for preoperative malignancy evaluation were as follows. In the cohort of non-follicular-neoplasm-lesions (non-FN-lesion), they were 95.16%, 53.85%, 90.77%, 70.00%, and 88.00% for CK19; 95.16%, 38.46%, 88.06%, 62.50%, and 85.33% for galectin-3; 77.42%, 76.92%, 94.12%, 41.67%, and 58.00% for HBME-1; 66.13%, 100.00%, 100.00%, 38.24%, and 72.00% for CD56; 90.32%, 92.31%, 98.25%, 66.67%, and 90.67% for NGS; and 88.71%, 92.30%, 98.21%, 63.16%, and 89.33% for integrated IHC. In the cohort of follicular neoplasms (FN), they were 30.43%, 77.77%, 77.77%, 30.43%, and 43.75% for CK19; 73.91%, 66.67%, 85.00%, 50.00%, and 71.88% for galectin-3; 26.09%, 88.89%, 85.71%, 32.00%, and 43.75% for HBME-1; 26.09%, 100.00%, 100.00%, 34.62%, and 46.88% for CD56; 52.17%, 88.89%, 92.31%, 42.11%, and 62.50% for NGS; 82.61%, 66.67%, 86.36%, 60.00%, and 78.13% for integrated IHC; and 100%, 66.67%, 88.46%, 100%, and 90.63% for integrated IHC-NGS. The application of biomarkers in distinguishing uncertain CNB samples of thyroid nodules is available and capable. CD56 negative or NGS positive suggests malignancy strongly for both FN and non-FN-lesion, which may be used as a “rule in” tool. The negative predictive value of the integrated IHC and the integrated IHC-NGS implies a high possibility to be benign for non-FN-lesion and FN separately, which can work as a “rule out” tool. Considering the balance of specificity and sensitivity, NGS is the best for non-FN-lesion and the integrated IHC-NGS is the best for FN.