bluuebunny/crossref_metadata_2025_split huggingface dataset:
Бeзпeковi аспeкти розвитку E-економіки
Authors: Наумік-Гладка К.Г. 
Published: June 2021

В статті розкрито особливості явища е-економіка. Визначені загрози та можливості формування та розвитку системи е-економіки в Україні.
Однiєю з актуальних характеристик е-економіки, що впливає на рівень економічної безпеки є нeвизначеність посадового статусу пeрсоналу у вiртуальних мeрeжних економічних зв’язках. Розмитiсть посад та зникнeння звичних посад унeможливлює класичний управлiнський вплив особливо в іноваційних віртуальних дистанційних виробничих системах. Формуються новi цeнтри впливу, – люди або групи людeй, що вiдiграють ключову роль в органiзацiї е-комунiкацiї.
Розвиток комунiкацiйних тeхнологiй зумовив появу нових концeптiв, таких як елeктронний уряд (e-government), елeктронна влада (e-governance), мобiльний уряд (m-government, mobile government), всюдисущий уряд (u-government ubiquitous government), всюдисущe суспiльство (u-society ubiquitous society), всюдисущe мiсто (u-city, ubiquitous city).
Електронні портали нe тiльки надають iнформацiю про організації, алe й дозволяють зробити окрeмi дiї, заради яких ранiшe насeлeння було змушeнe вiдвiдувати установи оффлайн. Сeрвeр eлeктронного порталу можe пiдтримувати кiлька роздiлiв одночасно, наприклад, пiдприємницька дiяльнiсть, освiта, зайнятiсть, охорона здоров'я, житло, консультування, е-торгівля.
На тeриторiї України реалізований рiзний досвiд впроваджeння eлeмeнтiв е-економіки - електронні кабінети, електронні скриньки для надсилання громадянами письмових звернень у вигляді сканкопій або фотокопій через засоби електронного зв’язку, для отримання інформаційно-довідкових послуг без використання електронного цифрового підпису, електронна пошта для консультацій для клієнтів. Кожен з цих напрямів має свій аспект кібербезпеки.
Наведено приклад пeрeлiку адмiнiстративних послуг економічного характеру, якi надаються з використанням Iнтeрнeту в Українi. Окреслено базові проблeми нормативного врeгулювання розвитку E - економіки в Українi.
Avaliação do efeito da sertralina sobre os tecidos periodontais de ratos Wistar com periodontite induzida
Authors: Correia Bruna Rafaela , Nassar Carlos Augusto , Adada Franciele Fernanda , Nassar Patricia Oehlmeyer , Grassiolli Sabrina , Schnaufer Thais Carolina 
Published: June 2021

A Saúde bucal está associada a doenças sistêmicas devido presença de microorganismos e, depressão é uma das patologias sistêmicas e um dos medicamentos para tratamento, é sertralina. Este estudo tem por objetivo avaliar os efeitos da sertralina em tecidos periodontais com ratos induzidos a periodontite por ligadura. Foram utilizados 40 ratos machos adultos, divididos em 4 grupos, grupo controle (GC), grupo com doença periodontal, (GDP), grupo sertralina (GS) e grupo doença periodontal e sertralina (GDPS). Os grupos com doença periodontal receberam uma ligadura ao redor dos primeiros molares pelo período de 30 dias, indução da doença ocorreu com os animais anestesiados e auxílio de pinça modificada, sonda exploradora, adicionando fio de algodão número 40 ao redor do primeiro molar inferior de ambos lados. Nos animais grupos GS e GDPS foram administradas doses de 5 mg/kg, os animais grupos GDP e GC receberam 1 mL/Kg de peso de solução fisiológica, avaliando consumo durante este período. Após período, os animais foram eutanasiados, com as hemi-mandíbulas retiradas e submetidas à análise histológica, morfológica e radiográfica. Os resultados, analisados pelo programa GraphPad Programa, apresentaram que animais GDP e GDPS não demonstraram diferença estatisticamente significante entre si (p>0,05), entretanto foram significativamente diferente dos outros grupos que não houve indução da doença periodontal (p<0,05). Assim, a sertralina na dose de 5mg/kg não promoveu efeito sobre os tecidos periodontais de ratos com doença periodontal induzida por ligadura.
Qualidade de vida em pessoas idosas submetidas ao tratamento de neoplasias
Authors: Novais Carlos Rafael Sousa , Reis Luciana Araújo dos , Assis Wagner Couto , Rabelo Lilian Almeida Nascimento , Guimarães Frank Evilácio de Oliveira , Britto Isnara Teixeira de , Reis Luana Araújo dos 
Published: June 2021

Objetivos: Descrever os impactos do tratamento de neoplasias na qualidade de vida dos idosos, a partir de uma revisão da literatura. Metodologia: Trata-se de um estudo descritivo, de abordagem qualitativa, cujo método utilizado foi à revisão não sistemática de literatura. A revisão foi embasada em referenciais teóricos e artigos científicos publicados no período de 2010 a 2020, disponíveis nas bases de dados virtuais: Scielo, LILACS e Bireme. Os critérios utilizados para a seleção dos artigos foram: artigos escritos no idioma português e com texto completo disponível para acesso gratuito. Resultados: A análise da literatura foi disposta em quatro subtemas: “Envelhecimento e Saúde”; “Qualidade de Vida da Pessoa Idosa”; “Neoplasias e seus Impactos na Saúde da Pessoa Idosa” e “Religiosidade, Espiritualidade e Crenças Pessoais”. Considerações Finais: Ao analisar os tópicos abordados é possível verificar que as mudanças na saúde do idoso interfere diretamente na qualidade de vida, principalmente quando submetido ao tratamento oncológico, quando o estado de saúde é ainda mais afetado.
Dificuldades do enfermeiro na atenção básica no cuidado às pessoas que vivem com HIV/AIDS
Authors: Pinheiro Noanna Janice , Paz Francisco Adalberto do Nascimento 
Published: June 2021

O vírus da imunodeficiência humana (HIV) é uma infecção sexualmente transmissível (IST) que atinge, principalmente, o sistema imunológico, afetando diversas pessoas no mundo, configurando então, um problema de saúde de publica. Na atenção primaria ocorre o primeiro contato entre enfermeiro e paciente, promovendo então, um atendimento com orientações claras sobre o vírus do HIV/Aids. Objetivo: foi analisar através de uma revisão de literatura as principais dificuldades na assistência de enfermagem às PVHIV na atenção básica. Metodologia: trata-se de uma revisão de literatura integrativa do tipo explicativa, de caráter qualitativo, realizada no período entre agosto de 2020 e maio de 2021, apresentando nas bases de dados da Plataforma da Biblioteca Virtual em Saúde (BVS) indexados nas bases de dados, Scientific Eletronic Library Online (SCIELO), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) Medical Literature Analysis and Retrieval System Online (MEDLINE). Foram incluídos estudos qualitativos e quantitativos, publicados nos últimos 10 anos no Brasil, com textos completos e disponíveis na integra e excluídos sem relevância para a temática e repetidos nas bases de busca. Após a leitura detalhada, foram selecionados 15 artigos para elaboração do estudo. Resultados: o estudo obteve dados que descrevem as dificuldades ao cuidado do enfermeiro as PVHIV, realizados em diferentes regiões do Brasil (Norte, Nordeste, Sul e Sudeste). Conclusão: Sendo assim os artigos mostram as falhas do sistema público frente a atenção primaria em que estão ligados a logística de insumos e matérias limitando a assistência e prejudicando o acesso de um serviço de qualidade.
Risk Assessment and Analysis in Health, Safety and Environmental (HSE) Hazards of Bitumenous Waterproofing Industry Using HAZID Technique
Authors: Dadgar Parisa 
Published: June 2021

Today, the use of risk assessment methods in various industries is expanding so that there are currently more than 70 types of different risk assessment methods in the world. These methods are usually used to identify, control and reduce the consequences of risks. The main methods of risk assessment are appropriate methods for risk assessment and their results can be used for management and decision-making to control and reduce its consequences. The purpose of this study is to identify and evaluate the risks to safety, health and the environment and to provide proposed and corrective solutions to reduce or eliminate HSE risks using the HAZID method. This descriptive cross-sectional study was performed for 4 months to identify the risks. For this purpose, a list of possible safety, health and environmental risks was prepared and the risk was evaluated by HAZID technique. In total, 5.15% of the identified risks are unacceptable, 20.62% are undesirable, 50.51% are acceptable, but 23.72% of the need for revision is minor. The results of this research include the implementation of measures such as safety training - professional training - inspection monitoring system - personnel safety management - preventive maintenance system management and forming a safety audit team - establishing regular House Keeping programs, etc. in identifying and Controls identified risks.
A Porcine Congenital Single-Sided Deafness Model, Its Population Statistics and Degenerative Changes
Authors: Ren Wei , Xu Cong , Zheng Fan-jun , Lin Ting-ting , Jin Peng , Zhang Yue , Guo Wei-wei , Liu Chuan-hong , Zhou Xiao-yang , Wang Lu-lu , Wang Yong , Zhao Hui , Yang Shi-ming 
Published: June 2021

ObjectiveTo describe and study the population statistics, hearing phenotype, and pathological changes of a porcine congenital single-sided deafness (CSSD) pedigree.MethodsClick auditory brainstem response (ABR), full-frequency ABR, and distortion product otoacoustic emission (DPOAE) were used to assess the hearing phenotype of the strain. Tympanogram was used to assess the middle ear function since birth. Celloidin embedding–hematoxylin–eosin (CE-HE) stain and scanning electron microscopy (SEM) were used to study the pathological changes of cochlear microstructures. Chi-square analysis was used to analyze the relation between hearing loss and other phenotypes.ResultsThe mating mood of CSSD with CSSD was most efficient in breeding-targeted CSSD phenotype (47.62%), and the prevalence of CSSD reached 46.67% till the fifth generation, where 42.22% were bilateral hearing loss (BHL) and 9.00% were normal hearing (NH) individuals. Hearing loss was proved to have no relation with coat color (P = 0.0841 &gt; 0.05) and gender (P = 0.4621 &gt; 0.05) by chi-square analysis. The deaf side of CSSD offspring in the fifth generation had no relation with that of their maternal parent (P = 0.2387 &gt; 0.05). All individuals in this strain exhibited congenital severe to profound sensorineural hearing loss with no malformation and dysfunction of the middle ear. The good hearing ear of CSSD stayed stable over age. The deaf side of CSSD and BHL presented cochlear and saccular degeneration, and the hair cell exhibited malformation since birth and degenerated from the apex to base turn through time. The pathology in BHL cochlea progressed more rapidly than CSSD and till P30, the hair cell had been totally gone. The stria vascularis (SV) was normal since birth and degenerated through time and finally exhibited disorganization of three layers of cells.ConclusionThis inbred porcine strain exhibited high and stable prevalence of CSSD, which highly resembled human non-syndromic CSSD disease. This porcine model could be used to further explore the etiology of CSSD and serve as an ideal tool for the studies of the effects of single-sided hearing deprivation on neural, cognitive, and behavioral developments and the benefits brought by CI in CSSD individuals.
Cardiac Dysfunction in a Mouse Vascular Dementia Model of Bilateral Common Carotid Artery Stenosis
Authors: An Lulu , Chopp Michael , Zacharek Alex , Shen Yi , Chen Zhili , Qian Yu , Li Wei , Landschoot-Ward Julie , Liu Zhongwu , Venkat Poornima 
Published: June 2021

Background:Cardiac function is associated with cognitive function. Previously, we found that stroke and traumatic brain injury evoke cardiac dysfunction in mice. In this study, we investigate whether bilateral common carotid artery stenosis (BCAS), a model that induces vascular dementia (VaD) in mice, induces cardiac dysfunction.Methods:Late-adult (6–8 months) C57BL/6J mice were subjected to sham surgery (n= 6) or BCAS (n= 8). BCAS was performed by applying microcoils (0.16 mm internal diameter) around both common carotid arteries. Cerebral blood flow and cognitive function tests were performed 21–28 days post-BCAS. Echocardiography was conducted in conscious mice 29 days after BCAS. Mice were sacrificed 30 days after BCAS. Heart tissues were isolated for immunohistochemical evaluation and real-time PCR assay.Results:Compared to sham mice, BCAS in mice significantly induced cerebral hypoperfusion and cognitive dysfunction, increased cardiac hypertrophy, as indicated by the increased heart weight and the ratio of heart weight/body weight, and induced cardiac dysfunction and left ventricular (LV) enlargement, indicated by a decreased LV ejection fraction (LVEF) and LV fractional shortening (LVFS), increased LV dimension (LVD), and increased LV mass. Cognitive deficits significantly correlated with cardiac deficits. BCAS mice also exhibited significantly increased cardiac fibrosis, increased oxidative stress, as indicated by 4-hydroxynonenal and NADPH oxidase-2, increased leukocyte and macrophage infiltration into the heart, and increased cardiac interleukin-6 and thrombin gene expression.Conclusions:BCAS in mice without primary cardiac disease provokes cardiac dysfunction, which, in part, may be mediated by increased inflammation and oxidative stress.
A 2-Dose AERAS-402 Regimen Boosts CD8+ Polyfunctionality in HIV-Negative, BCG-Vaccinated Recipients
Authors: Sivakumaran Dhanasekaran , Blatner Gretta , Bakken Rasmus , Hokey David , Ritz Christian , Jenum Synne , Grewal Harleen M. S. 
Published: June 2021

Despite the widespread use of BCG, tuberculosis (TB) remains a global threat. Existing vaccine candidates in clinical trials are designed to replace or boost BCG which does not provide satisfying long-term protection. AERAS-402 is a replication-deficient Ad35 vaccine encoding a fusion protein of the M. tuberculosis (Mtb) antigens 85A, 85B, and TB10.4. The present phase I trial assessed the safety and immunogenicity of AERAS-402 in participants living in India – a highly TB-endemic area. Healthy male participants aged 18–45 years with a negative QuantiFERON-TB Gold in-tube test (QFT) were recruited. Enrolled participants (n=12) were randomized 2:1 to receive two intramuscular injections of either AERAS-402 (3 x 1010viral particles [vp]); (n=8) or placebo (n=4) on study days 0 and 28. Safety and immunogenicity parameters were evaluated for up to 182 days post the second injection. Immunogenicity was assessed by a flow cytometry-based intracellular cytokine staining (ICS) assay and transcriptional profiling. The latter was examined using dual-color-Reverse-Transcriptase-Multiplex-Ligation-dependent-Probe-Amplification (dc-RT MLPA) assay. AERAS-402 was well tolerated, and no vaccine-related serious adverse events were recorded. The vaccine-induced CD8+ T-cell responses were dominated by cells co-expressing IFN-γ, TNF-α, and IL-2 (“polyfunctional” cells) and were more robust than CD4+ T-cell responses. Five genes (CXCL10, GNLY, IFI35, IL1BandPTPRCv2) were differentially expressed between the AERAS-402-group and the placebo group, suggesting vaccine-induced responses. Further, compared to pre-vaccination, three genes (CLEC7A, PTPRCv1andTAGAP)were consistently up-regulated following two doses of vaccination in the AERAS-402-group. No safety concerns were observed for AERAS-402 in healthy Indian adult males. The vaccine-induced predominantly polyfunctional CD8+T cells in response to Ag85B, humoral immunity, and altered gene expression profiles in peripheral blood mononuclear cells (PBMCs) indicative of activation of various immunologically relevant biological pathways.
First Symptoms of Primary Progressive Aphasia and Alzheimer's Disease in Brazilian Individuals
Authors: dos Reis Talita Gallas , Machado Thais Helena , Caramelli Paulo , Scornavacca Francisco , Fernandez Liana Lisboa , Beber Bárbara Costa 
Published: June 2021

Background: Primary Progressive Aphasia (PPA) is characterized by progressive language impairment due to focal degeneration of brain areas related to linguistic processing. The detection and differential diagnosis of PPA can be difficult with clinical features that may overlap with features of other neurological conditions, such as Alzheimer's disease (AD). The scientific production on PPA in Latin American patients is still scarce. This study investigated the first symptoms in a Brazilian sample of patients with PPA in comparison with AD patients.Method: We compared the first symptoms reported by caregivers of people with PPA (n = 20; semantic variant n = 8, non-fluent variant n = 7, logopenic variant n = 3, and unclassified cases n = 2) and AD (n = 16). Data were collected through the application of a structured questionnaire that was presented in an interview format to the caregiver who knew the patient best.Results: Anomia, paraphasias and motor speech difficulties were the first symptoms capable of differentiating patients with PPA from those with AD, while memory was exclusive of AD. Among the PPA variants, anomia was the initial symptom associated with the semantic variant, while motor speech difficulties were associated with the non-fluent variant. The results are discussed considering the unique cultural and sociodemographic characteristics of this studied population.Conclusion: This study demonstrated that some of the initial symptoms of PPA patients may be unique to clinical variants of PPA and of AD, and their investigation may be useful for the early and differential diagnosis of this population.
Integrative Analysis of Identifying Methylation-Driven Genes Signature Predicts Prognosis in Colorectal Carcinoma
Authors: Huang Hao , Fu Jinming , Zhang Lei , Xu Jing , Li Dapeng , Onwuka Justina Ucheojor , Zhang Ding , Zhao Liyuan , Sun Simin , Zhu Lin , Zheng Ting , Jia Chenyang , Cui Binbin , Zhao Yashuang 
Published: June 2021

BackgroundAberrant DNA methylation is a critical regulator of gene expression and plays a crucial role in the occurrence, progression, and prognosis of colorectal cancer (CRC). We aimed to identify methylation-driven genes by integrative epigenetic and transcriptomic analysis to predict the prognosis of CRC patients.MethodsMethylation-driven genes were selected for CRC using a MethylMix algorithm and LASSO regression screening strategy, and were further used to construct a prognostic risk-assessment model. The Cancer Genome Atlas (TCGA) database was obtained as the training set for both the screening of methylation-driven genes and the effect of genes signature on CRC prognosis. Then, the prognostic genes signature was validated in three independent expression arrays of CRC data from Gene Expression Omnibus (GEO).ResultsWe identified 143 methylation-driven genes, of which the combination of BATF, PHYHIPL, RBP1, and PNPLA4 expression levels was screened as a better prognostic model with the best area under the curve (AUC) (AUC = 0.876). Compared with patients in the low-risk group, CRC patients in the high-risk group had significantly poorer overall survival in the training set (HR = 2.184, 95% CI: 1.404–3.396, P &lt; 0.001). Similar results were observed in the validation set. Moreover, VanderWeele’s mediation analysis indicated that the effect of methylation on prognosis was mediated by the levels of their expression (HRindirect = 1.473, P = 0.001, Proportion mediated, 69.10%).ConclusionsWe identified a four-gene prognostic signature by integrative analysis and developed a risk-assessment model that is significantly associated with patients’ survival. Methylation-driven genes might be a potential prognostic signature for CRC patients.
A Pilot Study of Home-Based Exercise and Personalized Nutrition Counseling Intervention in Endometrial Cancer Survivors
Authors: Schwartz Amanda R. , Bartlett David B. , Johnson Johanna L. , Broadwater Gloria , Channell Meghan , Nolte Kimberly C. , Wilkes Patricia A. , Huffman Kim M. , Secord Angeles Alvarez 
Published: June 2021

IntroductionTo assess the feasibility of a home-based aerobic exercise and nutrition counseling intervention and effect on cardiorespiratory fitness, cardiovascular disease risk profile, and immune response in obese endometrial cancer survivors.MethodsA longitudinal pilot study assessed a 12-week home-based aerobic exercise and nutrition counseling intervention in obese endometrial cancer survivors. The primary outcome was feasibility defined as 80% adherence to weekly walking sessions calculated among individuals that completed the intervention. Secondary outcomes comprised pre- and post-intervention differences in cardiorespiratory fitness, cardiovascular risk factors, and T-cell function. Descriptive statistics summarized data. Wilcoxon sign tests identified differences between and pre and post-intervention variables.ResultsNineteen women with stage 1 endometrial cancer consented; 9 withdrew and one was a screen failure. Median adherence to weekly walking sessions was 83.3%. Body composition was significantly altered with a reduction in median fat mass from 52.5 kg to 46.9 kg (p=0.04), and BMI from 37.5 kg/m2 to 36.2 kg/m2 (p = 0.004). There was no significant difference in cardiorespiratory fitness or cardiovascular parameters. The percentage of CD4+ and CD8+ T-cells producing IFNγ towards MAGE-A4 significantly increased from and 5.9% to 7.2% (p=0.043) and 13.9% to 14.8% (p=0.046), respectively. There were 3 related adverse events: hip pain, back sprain, and abdominal pain.DiscussionOur home-based exercise and nutrition counseling program was feasible based on 80% adherence to walking sessions and favored altered body composition. However, the discontinuation rate was high and further research is needed to overcome barriers to implementation. Improvement in cardiovascular parameters will most likely require longer and more intensive programs.
Epidemiology and Survival of Patients With Brainstem Gliomas: A Population-Based Study Using the SEER Database
Authors: Liu Huanbing , Qin Xiaowei , Zhao Liyan , Zhao Gang , Wang Yubo 
Published: June 2021

BackgroundBrainstem glioma is a primary glial tumor that arises from the midbrain, pons, and medulla. The objective of this study was to determine the population-based epidemiology, incidence, and outcomes of brainstem gliomas.MethodsThe data pertaining to patients with brainstem gliomas diagnosed between 2004 and 2016 were extracted from the SEER database. Descriptive analyses were conducted to evaluate the distribution and tumor-related characteristics of patients with brainstem gliomas. The possible prognostic indicators were analyzed by Kaplan-Meier curves and a Cox proportional hazards model.ResultsThe age-adjusted incidence rate was 0.311 cases per 100,000 person-years between 2004 and 2016. A total of 3387 cases of brainstem gliomas were included in our study. Most of the patients were white and diagnosed at 5-9 years of age. The most common diagnosis confirmed by histological review was ependymoma/anaplastic ependymoma. The median survival time was 24 months. Patients with tumors less than 3 cm in size had a better prognosis. Surgery was effective at improving overall survival. There was no evidence that radiotherapy and chemotherapy improved overall survival.ConclusionBrainstem gliomas can be diagnosed at any age. Ependymoma/anaplastic ependymoma is the most common pathological diagnosis. The prognosis is poor, and timely diagnosis and surgery are effective at improving the prognosis. We suggest that more attention should be given to the treatment of patients with brainstem gliomas.