bluuebunny/crossref_metadata_2025_split huggingface dataset:
tumba de hierro del empresario Francisco Peña Vaquero
Authors: Palazón Botella Mª Dolores , Molina Gómez José Antonio 
Published: December 2021

El cementerio Nuestro Padre Jesús de Murcia atesora una tumba de hierro única, impulsada por Francisco Peña Vaquero, un industrial propietario de una de las fundiciones más importantes de la Murcia en el cruce de los siglos XIX y XX, para el que el trabajo lo era todo. Sobre ese material se proyectaría un programa iconográfico que combina elementos tradicionales del mundo de la muerte con un repertorio centrado en los propios útiles de su actividad profesional. La suma de todo ello daría como resultado un catafalco desde el que se proclamaban los ideales de la resurrección cristiana a partir del esfuerzo laboral desarrollado durante la vida. Analizar estos aspectos y vincularlos con los aportes económicos y funerarios de su contexto nos dará las pautas para abordar el análisis de su significado.
The cemetery of Nuestro Padre Jesús in Murcia treasures a unique iron tomb, promoted by Francisco Peña Vaquero, an industrialist and owner of one of the most important foundries in Murcia at the crossroads of the nineteenth and twentieth centuries, for whom work was everything. An iconographic program was projected on iron combining traditional elements of the world of death with a repertoire centered on the tools of his professional activity. The sum of all this would result in a catafalque from which the ideals of Christian resurrection were proclaimed from the labor effort developed during life. Analyzing these aspects and linking them with the economic and funerary contributions of their context will give us the guidelines to approach the analysis of their meaning.
muerte no existe; variaciones en los rituales de velación y cremación frente a la inhumación. Tipologías actuales de tanatorios y camposantos
Authors: Lorite Cruz Pablo Jesús 
Published: December 2021

Este artículo compara los antiguos rituales funerarios de velación (celebrados en las casas) e inhumación (en los cementerios, con su ritual de costumbres, en los que la presentación del cadáver era muy importante) con los nuevos rituales de velación en los tanatorios (lugares pensados para que la muerte no exista y se camufle con la vida), la cremación y los nuevos depósitos para depositar las cenizas (árboles, lagos, columbarios escondidos en las ciudades, ceniceros comunales...) o deshacerse de ellas. En estos (mar, aire, praderas en los cementerios, circuitos de agua...) no se conserva la reliquia sino la memoria, intentando esconder la muerte y aceptando falsamente que ésta no existe.
This article compares the old funeral rituals of vigil (celebrated at home) and burial in cemeteries (with a long ritual full of customs where the presentation of the corpse was very important) with the new funeral rituals celebrated in funeral homes (places designed so that death does not exist and is camouflaged with life), the cremation and new places to deposit the ashes (trees, lakes, columbariums hidden in cities, communal ashtrays...) or getting rid of these through a new way where the relic is not preserved (sea, air, meadows in cemeteries, water circuits...), but the memory; trying to hide death and falsely accepting that it does not exist.
Ver o mundo pelos olhos da fé. Análise filosófico-teológica da “visão de mundo” de “padres novos”
Authors: Lopes Gonçalves Paulo Sergio 
Published: December 2021

Objetiva-se neste artigo analisar filosófica e teologicamente a “visão de mundo” de dados coletados de “padres novos”. Justifica-se esse objetivo porque a “visão de mundo” é a constituição de “imagem de mundo” e, por conseguinte, é uma força ou uma potência que permite olhar e situar-se no mundo. Nesse sentido, a “visão de mundo” de “padres novos” permite que se conceba que vejam, a partir de mundo, o próprio “mundo real” e que, por conseguinte, por exercitarem o ministério presbiteral, possam ter a contribuição da teologia para a elaboração de sua “visão de mundo”. Por isso, é fundamental que essa análise visualize, nas respostas dos “padres novos”, não apenas a descrição empírica, mas também o que subjaz e o que pode aparecer nessa “visão”, principalmente quando potencializada pela teologia. Para atingir esse objetivo, será conceituado, filosoficamente, “visão de mundo” como “imagem de mundo”, para em seguida descrever analiticamente a “visão de mundo” de “padres novos” e vislumbrar como a teologia pode levar ao aprofundamento da “visão de mundo”, possibilitando a “honestidade com o real” do mundo e a própria fé revelada, que ilumina a teologia para que seja efetivamente scientia fidei.
Realidades emergentes do mundo de hoje e perfil dos “padres novos”
Authors: Pinto Carias Celso 
Published: December 2021

Em busca do perfil dos “padres novos”, em primeiro momento, o texto faz um breve relatório dos dados e uma análise preliminar dos mesmos em torno de quatro questões relativas à Visão de Mundo — principais antivalores reinantes na sociedade atual, principais valores que emanam na sociedade atual, novas realidades positivas que estão emergindo no mundo de hoje e novas realidades que se considera negativas no mundo de hoje. Em um segundo momento, faz-se uma análise dos dados em um contexto mais amplo, configurado por uma crise civilizatória, que nos imerge em uma mudança de época, como salientou a Conferência de Aparecida. Procura-se responder em que medida o perfil dos “padres novos” responde aos desafios da evangelização na perspectiva da renovação do Vaticano II e da tradição eclesial libertadora da Igreja na América Latina, em meio à crise atual do projeto civilizacional moderno.
Teaching Computational Thinking
Authors: Neumann Maureen D. , Dion Lisa , Snapp Robert 
Published: December 2021

A guide for educators to incorporate computational thinking—a set of cognitive skills applied to problem solving—into a broad range of subjects.
Computational thinking—a set of mental and cognitive tools applied to problem solving—is a fundamental skill that all of us (and not just computer scientists) draw on. Educators have found that computational thinking enhances learning across a range of subjects and reinforces students' abilities in reading, writing, and arithmetic. This book offers a guide for incorporating computational thinking into middle school and high school classrooms, presenting a series of activities, projects, and tasks that employ a range of pedagogical practices and cross a variety of content areas.
As students problem solve, communicate, persevere, work as a team, and learn from mistakes, they develop a concrete understanding of the abstract principles used in computer science to create code and other digital artifacts. The book guides students and teachers to integrate computer programming with visual art and geometry, generating abstract expressionist–style images; construct topological graphs that represent the relationships between characters in such literary works as Harry Potter and the Sorcerer's Stone and Romeo and Juliet; apply Newtonian physics to the creation of computer games; and locate, analyze, and present empirical data relevant to social and political issues. Finally, the book lists a variety of classroom resources, including the programming languages Scratch (free to all) and Codesters (free to teachers). An accompanying website contains the executable programs used in the book's activities.
The open access edition of this book was made possible by generous funding from Arcadia – a charitable fund of Lisbet Rausing and Peter Baldwin.
Well-Being Programme for Caregivers of Persons with Spinal Cord Injury
Authors: Srikanth Pallerla , K. Shanivaram Reddy , Nirmala B. P. , N. Janardhana , Gupta Anupam 
Published: December 2021

Background: SCI is a high-cost chronic disability, and it is a life-changing experience for family members and societies. For families, the unpredictable nature of the injury leads some of the members into an 'unexpected career' as family caregivers, the caregiver’s have to put enormous efforts, to provide continuous full-time caregiving for the recovery of Person with Spinal cord injury, which will affect the caregiver's physical and mental health. The current study aims to develop and test the feasibility of a well-being programme for caregivers of persons with spinal cord injury.
Methods/Design: The current study adopts a Quasi-experimental study design, which have three phases; the first phase is to explore the needs of the caregivers by conducting in-depth interviews with different stakeholders. The second phase is to develop a well-being programme, and checking the feasibility of the programme is the third phase by recruiting 24 caregivers. Qualitative data will be analyzed using thematic analysis, whereas quantitative data will be analyzed using appropriate parametric or non- parametric tests upon confirming normality of data distribution.
Discussion: This study would help us to understand the psycho-social issues and unique needs of the caregivers at different time periods. It also gives information about psycho-social interventions and outcome measures for the well-being of the caregivers.
Identification of HMMR as a prognostic biomarker for patients with lung adenocarcinoma via integrated bioinformatics analysis
Authors: Li Zhaodong , Fei Hongtian , Lei Siyu , Hao Fengtong , Yang Lijie , Li Wanze , Zhang Laney , Fei Rui 
Published: December 2021

Background
Lung adenocarcinoma (LUAD) is the most prevalent tumor in lung carcinoma cases and threatens human life seriously worldwide. Here we attempt to identify a prognostic biomarker and potential therapeutic target for LUAD patients.

Methods
Differentially expressed genes (DEGs) shared by GSE18842, GSE75037, GSE101929 and GSE19188 profiles were determined and used for protein-protein interaction analysis, enrichment analysis and clinical correlation analysis to search for the core gene, whose expression was further validated in multiple databases and LUAD cells (A549 and PC-9) by quantitative real-time PCR (qRT-PCR) and western blot analyses. Its prognostic value was estimated using the Kaplan-Meier method, meta-analysis and Cox regression analysis based on the Cancer Genome Atlas (TCGA) dataset and co-expression analysis was conducted using the Oncomine database. Gene Set Enrichment Analysis (GSEA) was performed to illuminate the potential functions of the core gene.

Results
A total of 115 shared DEGs were found, of which 24 DEGs were identified as candidate hub genes with potential functions associated with cell cycle and FOXM1 transcription factor network. Among these candidates, HMMR was identified as the core gene, which was highly expressed in LUAD as verified by multiple datasets and cell samples. Besides, high HMMR expression was found to independently predict poor survival in patients with LUAD. Co-expression analysis showed that HMMR was closely related to FOXM1 and was mainly involved in cell cycle as suggested by GSEA.

Conclusion
HMMR might be served as an independent prognostic biomarker for LUAD patients, which needs further validation in subsequent studies.
Spontaneous Atomic Sites Formation in Wurtzite CoO Nanorods for Robust CO2 Photoreduction
Authors: Wei Jishi , Meng Fan Lu , Li Tongtao , Zhang Tianxi , Xi Shibo , Ong Wei Li , Wang Xiao‐Qiao , Zhang Xinyue , Bosman Michel , Ho Ghim Wei 
Published: December 2021

AbstractControlled incorporation of single atoms in a suitable host matrix can result in a radical transformation in catalytic properties. However, finding a straightforward synthetic strategy that offers a compelling combination of solution processing, atomic doping and a matching host is still a grand challenge. Here, a spontaneous heteroatom formation of atomic Zn sites in well‐defined wurtzite CoO nanorods, delivering high photoreduction rates, reaching 86.7 µmol g−1 h−1 for CO and 31.4 µmol g−1 h−1 for CH4 production is reported. Based on the validation of atomic Zn sites structures, catalytic process tracking via in situ/ex situ spectroscopic probes, and related structural simulations, a good description of the catalytic reaction kinetics for Zn/CoO as a function of applied potential is established, revealing how the single doping sites influence the CO2 photoreduction.
Generation of Alveolar Epithelium Using Reconstituted Basement Membrane and hiPSC‐Derived Organoids
Authors: He Yong , Rofaani Elrade , Huang Xiaochen , Huang Boxin , Liang Feng , Wang Li , Shi Jian , Peng Juan , Chen Yong 
Published: December 2021

AbstractIn vitro modeling of alveolar epithelium needs to recapitulate features of both cellular and noncellular components of the lung tissues. Herein, a method is presented to generate alveolar epithelium by using human induced pluripotent stem cells (hiPSCs) and reconstituted or artificial basement membrane (ABM). The ABM is obtained by self‐assembling type IV collagen and laminin with a monolayer of crosslinked gelatin nanofibers as backbone and a patterned honeycomb microframe for handling. Alveolar organoids are obtained from hiPSCs and then dissociated into single cells. After replating the alveolar cells on the ABM and a short‐period incubation under submerged and air–liquid interface culture conditions, an alveolar epithelium is achieved, showing high‐level expressions of both alveolar cell‐specific proteins and characteristic tight junctions. Besides, endothelial cells derived from the same hiPSCs are cocultured on the backside of the epithelium, forming an air–blood barrier. The method is generic and can potentially be applied to other types of artificial epithelium and endothelium.
Therapeutic Potentials of Poly (ADP‐Ribose) Polymerase 1 (PARP1) Inhibition in Multiple Sclerosis and Animal Models: Concept Revisiting
Authors: Wang Yan , Pleasure David , Deng Wenbin , Guo Fuzheng 
Published: December 2021

AbstractPoly (ADP‐ribose) polymerase 1 (PARP1) plays a fundamental role in DNA repair and gene expression. Excessive PARP1 hyperactivation, however, has been associated with cell death. PARP1 and/or its activity are dysregulated in the immune and central nervous system of multiple sclerosis (MS) patients and animal models. Pharmacological PARP1 inhibition is shown to be protective against immune activation and disease severity in MS animal models while genetic PARP1 deficiency studies reported discrepant results. The inconsistency suggests that the function of PARP1 and PARP1‐mediated PARylation may be complex and context‐dependent. The article reviews PARP1 functions, discusses experimental findings and possible interpretations of PARP1 in inflammation, neuronal/axonal degeneration, and oligodendrogliopathy, three major pathological components cooperatively determining MS disease course and neurological progression, and points out future research directions. Cell type specific PARP1 manipulations are necessary for revisiting the role of PARP1 in the three pathological components prior to moving PARP1 inhibition into clinical trials for MS therapy.
Sulfonated Graphene Aerogels Enable Safe‐to‐Use Flexible Perovskite Solar Modules
Authors: Li Zhen , Wu Xin , Li Bo , Zhang Shoufeng , Gao Danpeng , Liu Yizhe , Li Xintong , Zhang Ningbin , Hu Xiaotian , Zhi Chunyi , Jen Alex K.‐Y. , Zhu Zonglong 
Published: December 2021

AbstractThe potential leakage of lead from degraded perovskite photovoltaics poses a threat to the ecosystem and human health, which is a severe hurdle for their commercialization, especially for flexible modules that are often integrated in applications used in daily living. To trap the lead from degraded flexible perovskite solar modules (PVSMs), sulfonated graphene aerogels mixed with polydimethylsiloxane are employed to serve as lead‐absorbing encapsulants on both sides of flexible PVSMs. The large specific area of sulfonated graphene aerogels and their high binding energy with Pb2+ give them superior lead adsorption capacity in aqueous solution. Over 99% of Pb2+ from the degraded flexible PVSMs can be captured by the encapsulant under different simulated conditions (scratching, bending, and thermal circling) to reduce the lead leakage to ≈10 ppb. Moreover, the lead from degraded flexible PVSMs can be minimized to far below the hazardous waste limit according to the resource conservation and recovery act regulation (RCRA). This work provides an effective strategy to realize safe‐to‐use perovskite‐based flexible electronics to facilitate their commercialization.
Thermal decomposition behaviors of a self‐intumescent flame retardant epoxy resin
Authors: Zhao Cheng‐Shou , Yang Han‐Ming , Jiang Yi‐Song , Cui Hong‐wei , Luo Zhen‐Jun , Kong De‐Yan , Peng Hua‐Qiao , Esmaeili Nima 
Published: December 2021

AbstractThis paper focuses on revealing the thermal decomposition behaviors of a self‐intumescent flame retardant (IFR) epoxy (EP) resin (EP/15%APP‐Cu2O) employing 12 wt% ammonium polyphosphate (APP) as a halogen‐free flame retardant and 3 wt% copper (I) oxide (Cu2O) as char forming rate regulator. Initially, the thermal stability of EP/15%APP‐Cu2O was analyzed and compared to virgin EP resin and flame retardant EP (EP/15%APP) containing 15 wt% APP as flame retardant by thermogravimetric analysis test at different heating rates under nitrogen atmosphere. It was shown that the incorporation of APP altered the decomposition pathway of EP and decreased the onset decomposition temperature. Luckily, compared to EP/15%APP, the onset decomposition temperature of EP/15%APP‐Cu2O was just slightly reduced from 300.4 to 292.8°C. Then, the thermal degradation kinetics of EP, EP/15%APP and EP/15%APP‐Cu2O were further evaluated by Kissinger and Flynn‐Wall‐Ozawa methods. It was worth noted that the addition of APP or APP‐Cu2O enhanced the thermal degradation activation energies of EP, which contributed to the protective effect of the char formation. Particularly, the incorporation of 3 wt% Cu2O significantly decreased the thermal degradation activation energies at the early decomposition stage of EP. This may be the main contribution for intumescent char formation, which resulted in higher fire safety of EP/15%APP‐Cu2O compared to EP/15%APP. These information can potentially help to develop alternative IFR systems.
In vitro and in silico studies of fluorinated 2,3‐disubstituted thiazolidinone‐pyrazoles as potential α‐amylase inhibitors and antioxidant agents
Authors: Ganavi Devaraj , Ramu Ramith , Kumar Vasantha , Patil Shashank M. , Martiz Reshma M. , Shirahatti Prithvi S. , Sathyanarayana Reshma , Poojary Boja , Holla B. Shivarama , Poojary Vishwanatha , Kumari K. P. Nanda , Shivachandra Jagadeep Chandra 
Published: December 2021

AbstractAs part of our effort to identify potent α‐amylase inhibitors, in the present study, a novel series of fluorinated thiazolidinone‐pyrazole hybrid molecules were prepared by the condensation of 3‐(aryl/benzyloxyaryl)‐pyrazole‐4‐carbaldehydes with fluorinated 2,3‐disubstituted thiazolidin‐4‐ones. The structures of the newly synthesized compounds were confirmed by infrared,1H nuclear magnetic resonance (NMR),13C NMR, and liquid chromatography–mass spectrometry data. All the compounds were screened for their α‐amylase inhibitory and free radical scavenging activities by DPPH (1,1‐diphenyl‐2‐picrylhydrazyl) and ABTS methods. Among the tested compounds, compound8gemerged as a promising α‐amylase inhibitor with IC50 = 0.76 ± 1.23 µM, and it was found to be more potent than the standard drug acarbose (IC50 = 0.86 ± 0.81 μM). Compounds8band8gshowed strong free radical scavenging activity compared to the standard butylated hydroxyl anisole. The kinetic study of compound8grevealed the reversible, classical competitive inhibition mode on the α‐amylase enzyme. Molecular docking and dynamic simulations studies were performed for the most potent compound8g, which displayed remarkable hydrogen bonding with the α‐amylase protein (PDB ID: 1DHK).
Output feedback controller design for discrete LTI systems with polytopic uncertainty via direct searching of the design space
Authors: Abolpour Roozbeh , Dehghani Maryam , Talebi Heidar Ali 
Published: December 2021

AbstractThis paper concerns static output feedback stabilization of polytopic discrete linear time‐invariant (LTI) systems. The previous related studies were mainly based on linear matrix inequality (LMI) approaches which are naturally conservative. In this paper, a novel design algorithm is presented that iteratively partitions a primary design space to subspaces. Then, by assessing stabilizability status of each generated subspace, the algorithm determines the total stabilizable parts and removes the undesired parts of the design space. Mathematical theories are developed to determine the total de‐stabilizability or stabilizability of a given subspace. These subspaces' properties are detected through checking the existence of critical polynomials (which have roots on the unit circle of the complex plane) on their exposed edges. By omitting the undesired parts of the design space, the algorithm just searches the desired parts which are far smaller than the primary design space. This strategy improves the feasibility performance of the algorithm. Some illustrating examples are provided to show the steps of the design algorithm. Furthermore, 100 random models are generated to evaluate the feasibility performance of the proposed algorithm as compared to some existing methods. The results reveal the superiority of the proposed algorithm.
The harsh environment where exoplanets live
Authors: Pillitteri Ignazio 
Published: December 2021

AbstractThe X‐ray and Extreme Ultraviolet (XUV) actvity of the Sun has determined important effects on the planets around it. In particular, high doses of X‐rays, flares, and coronal mass ejections (CMEs) combined with masses and sizes of the planets and the shielding action of the planetary magnetic fields have determined the diverse habitability of rocky planets like Venus, Earth, and Mars. In exoplanetary systems, the same could apply, especially in those stars with close‐in planets like hot Jupiter's or Earth analogs around M dwarfs. These planets live in the harsh environment of the hot coronal fringes. This has a consequence on the evaporation and the photochemistry of the upper atmospheres of such planets. Furthermore, phenomena related to gravitational and magnetic interaction between stars and close‐in planets could be at work. Effects due to star–planet interaction could be the transfer of rotational momentum between planet and star, magnetic interaction between the fields of planet and star that could potentially lead to flares in the outer corona, evaporation with the formation of a cloud of planetary gas around the star, and accretion onto the star itself. In this review, I will report on the search for such phenomena at XUV bands with X‐ray observatories like XMM‐Newton.