bluuebunny/crossref_metadata_2025_split huggingface dataset:
Practice Approaches to the Digital Transformations of Diplomacy: Toward a New Research Agenda
Authors: Hedling Elsa , Bremberg Niklas 
Published: June 2021

AbstractAs a growing number of diplomatic practices take new digital forms, research on digital diplomacy is rapidly expanding. Many of the changes linked to digitalization transform or challenge traditional ways of doing diplomacy. Analyses of new forms of “digital diplomacy” are therefore valuable for the advancement of practice approaches in international relations theory. That said, digital diplomacy poses a number of challenges for international relations scholarship that are only beginning to be addressed. Digitalization is both a process and a result, and provokes key questions regarding continuity, change, agency, space, and materiality in diplomacy. The overarching aim of this article is to advance a research agenda that seeks to address key questions in the study of digital diplomacy on the basis of various practice approaches. In particular, the article highlights three dimensions of change as being central to the research agenda and investigates how these can be explored in future analyses of digital diplomacy.
Molecular Identification of Leafmining Flies From Australia Including New Liriomyza Outbreaks
Authors: Xu Xuefen , Coquilleau Marianne P , Ridland Peter M , Umina Paul A , Yang Qiong , Hoffmann Ary A 
Published: June 2021

Abstract
Some leafmining fly species are pests of agricultural and ornamental plants but they also include many species with little economic importance. The taxonomy of leafmining flies is often challenging because of putative cryptic species. Following new outbreaks of Liriomyza (Diptera:Agromyzidae) in Australia, we here characterize 13 dipteran leafminer species collected from Australia based on cytochrome c oxidase subunit 1 (COI) DNA barcodes, and we compare these with overseas data. We confirm barcodes of nine species from the Agromyzidae (Liriomyza sativae, L. huidobrensis, L. trifolii, L. bryoniae, L. chinensis, L. brassicae, L. chenopodii, Phytomyza plantaginis and P. syngenesiae) and one species from the Drosophilidae (Scaptomyza flava); we describe new haplotypes for some of these species. Furthermore, we provide the first DNA barcodes for two species (Cerodontha milleri and Phytoliriomyza praecellens) from the Agromyzidae and one species (Scaptomyza australis) from the Drosophilidae. These findings provide a baseline for DNA-based identification of pest Liriomyza incursions spreading across the Australian east coast in relation to other species already present in Australia.
Financial Incentives and Competitive Pressure: The Case of the Hospital Industry
Authors: Choné Philippe , Wilner Lionel 
Published: June 2021

Abstract
In the late 2000s, a regulatory reform dramatically strengthened the incentives of French nonprofit (NP) hospitals to attract patients. Exploiting exhaustive data for surgery treatments between 2005 and 2008, and modeling hospitals as supplying utility to patients, we show that increased competitive pressure on NP hospitals caused them to perform more procedures, but did not inflate overall activity at the industry level. Although they have gained market shares over their for-profit (FP) counterparts, NP hospitals have been significantly worse off after the reform. To adjust to stronger financial incentives, they incurred an additional effort (pecuniary and non-pecuniary costs) equivalent to about a quarter of their annual revenue.
Emerging technologies for cervical cancer screening
Authors: Hamashima Chisato 
Published: June 2021

Abstract
Cervical cancer remains a concern worldwide, and cervical cancer screening plays an important role in reducing the burden of this disease. Although cytology is still the main strategy for cervical cancer screening, it has gradually changed to human papillomavirus testing. The specificity of human papillomavirus testing is lower than that of cytology, which leads to an increased rate of colposcopy after positive results. To decrease colposcopic examinations, an efficient triage method is needed for human papillomavirus screening. New biomarkers have been developed and evaluated for primary screening and triage of abnormal cytology or human papillomavirus-positive results. Their sensitivity and specificity were estimated and compared with those of cytology. In the present study, the following new techniques were examined: p16/Ki67 dual staining, DNA methylation, micro-ribonucleic acid, chromosomal abnormalities, Claudins and DNA ploidy. Evaluation studies of p16/Ki67 dual staining and DNA methylation were more advanced than those of other options. When p16/Ki67 dual staining was used for triage for human papillomavirus testing, the sensitivity of 2 or greater cervical intraepithelial neoplasia (CIN2+) detection was higher than that of cytology without decreased specificity. Although there are several types of DNA methylation, sensitivity and specificity were moderate for detecting CIN2+. S5 classifier is a commercialized product that consists of viral methylation, and high sensitivity with decreased specificity has been reported. Considering its combination with self-sampling, DNA methylation is a highly anticipated technique along with human papillomavirus testing for the next generation of cervical cancer screening. However, the backgrounds for cervical cancer screening differ among countries and further study is needed to identify the best available method.
In-silico HMG-CoA reductase-inhibitory and in-vivo anti-lipidaemic/anticancer effects of carotenoids from Spondias mombin
Authors: Metibemu Damilohun Samuel , Akinloye Oluseyi Adeboye , Akamo Adio Jamiu , Okoye Jude Ogechukwu , Omotuyi Idowu Olaposi 
Published: June 2021

Abstract

Objectives
Inhibition of HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase, the rate rate-determining enzyme for the biogenesis of cholesterol is known to show antineoplastic effects. Therefore, this study investigates the in-silico HMG-CoA reductase (HMGCR)-inhibitory and in-vivo anti-lipidaemic/anticancer effects of carotenoids from Spondias mombin.

Methods
Carotenoids from S. mombin leaves were characterized with the aid of liquid chromatography–electrospray ionization–mass spectrometry (LC-ESI-MS). The characterized phytochemicals were obtained from PubChem. They were docked into the orthosteric site of human HMGCR (Protein Data Bank code 1HW8) using AutoDock 4.0 suites. DMBA (7,12-dimethylbenz[a]anthracene) model of breast cancer was treated with the carotenoids extract from S. mombin (100 mg/kg and 200 mg/kg doses) to assess its anti-lipidaemic cum anticancer effects.

Key findings
Carotenoids from S. mombin; beta-carotene-15,15′-epoxide, astaxanthin and 7,7′,8,8′-tetrahydro-β-β-carotene demonstrate HMGCR inhibition. They form hydrophobic interactions with key residues within the catalytic domain of HMGCR. The carotenoids extract exhibits anti-lipidaemic/anticancer effects, lowering serum triglyceride, LDL and cholesterol concentration. It increases HDL concentration and downregulates the expression of HMGR, AFP, CEACAM-3, BRCA-1 and HIF-1 mRNAs.

Conclusion
Carotenoids from S. mombin demonstrate HMG-CoA reductase (HMGCR) inhibition, anti-lipidaemic, and anticancer effects. The inhibition of HMGCR by the carotenoids extract further poses it as a potential anti-hypercholesterolaemia compounds.
Malignant phyllodes tumor with synchronous metastases to axillary lymph nodes, lung at the presentation: a case report and literature review
Authors: Le Quang Hong , Mai Vuong The 
Published: June 2021

Abstract
Phyllodes tumors are rare mesenchymal tumors of breast. Malignant phyllodes tumors can develop metastases to distal organs with spreading hematogenously to most frequent sites as lungs, bone and brain. Regional lymph node enlargement is common but metastasis to lymph node is a very rare phenomenon with prevalence about 1.1–3.8%. In this report, we introduce a case of malignant phyllodes tumor of breast in 57-year-old female patient. Synchronous metastases to axillary lymph nodes and lung were found at the presentation. She was treated with mastectomy combined with axillary lymph node dissection and adjuvant chemotherapy. Axillary lymph node dissection can be considered in case of proven metastatic or suspiciously palpable lymph nodes.
Renal hydatidosis masquerading as xanthogranulomatous pyelonephritis: a new case report
Authors: Hermi Amine , Ouanes Yassine , Tapsoba Abdoulkader , Zehani Alia Kassar , Chaker Kays , Bibi Mokhtar , Daly Kheireddine Mrad , Sellami Ahmed , Rhouma Sami Ben , Nouira Yassine 
Published: June 2021

Abstract
Human hydatid disease is still endemic in pastoral and rangeland areas, with temperate climate, mainly in the southern shore of the Mediterranean, particularly in the Maghreb countries. Renal localization is rare although it is the most frequent site of the urinary tract. Its clinical evolution remains silent for long time, and the diagnosis is often elusive for years. Renal hydatid cysts may pose a problem of differential diagnosis. Our case concerns a renal hydatidosis misdiagnosed as a xanthogranulomatous pyelonephritis, treated by total nephrectomy.
Multiwavelength continuum sizes of protoplanetary discs: scaling relations and implications for grain growth and radial drift
Authors: Tazzari M , Clarke C J , Testi L , Williams J P , Facchini S , Manara C F , Natta A , Rosotti G 
Published: June 2021

ABSTRACT
We analyse spatially resolved ALMA observations at 0.9, 1.3, and 3.1 mm for the 26 brightest protoplanetary discs in the Lupus star-forming region. We characterize the discs multiwavelength brightness profiles by fitting the interferometric visibilities in a homogeneous way, obtaining effective disc sizes at the three wavelengths, spectral index profiles, and optical depth estimates. We report three fundamental discoveries: first, the millimetre continuum size–luminosity relation already observed at 0.9 mm is also present at 1.3 mm with an identical slope, and at 3.1 mm with a steeper slope, confirming that emission at longer wavelengths becomes increasingly optically thin. Second, when observed at 3.1 mm the discs appear to be only 9 per cent smaller than when observed at 0.9 mm, in tension with models of dust evolution that predict a starker difference. Third, by forward modelling the sample of measurements with a simple parametric disc model, we find that the presence of large grains ($a_\mathrm{max}\gt 1\,$ mm) throughout the discs is the most favoured explanation for all discs as it reproduces simultaneously their spectral indices, optical depth, luminosity, and radial extent in the 0.9–1.3 mm wavelength range. We also find that the observations can be alternatively interpreted with the discs being dominated by optically thick, unresolved, substructures made of mm-sized grains with a high scattering albedo.
A type III-A CRISPR–Cas system mediates co-transcriptional DNA cleavage at the transcriptional bubbles in close proximity to active effectors
Authors: Lin Jinzhong , Shen Yulong , Ni Jinfeng , She Qunxin 
Published: June 2021

Abstract
Many type III CRISPR–Cas systems rely on the cyclic oligoadenylate (cOA) signaling pathway to exert immunization. However, LdCsm, a type III-A lactobacilli immune system mediates efficient plasmid clearance in spite of lacking cOA signaling. Thus, the system provides a good model for detailed characterization of the RNA-activated DNase in vitro and in vivo. We found ATP functions as a ligand to enhance the LdCsm ssDNase, and the ATP enhancement is essential for in vivo plasmid clearance. In vitro assays demonstrated LdCsm cleaved transcriptional bubbles at any positions in non-template strand, suggesting that DNA cleavage may occur for transcribing DNA. Destiny of target plasmid versus nontarget plasmid in Escherichia coli cells was investigated, and this revealed that the LdCsm effectors mediated co-transcriptional DNA cleavage to both target and nontarget plasmids, suggesting LdCsm effectors can mediate DNA cleavage to any transcriptional bubbles in close proximity upon activation. Subcellular locations of active LdCsm effectors were then manipulated by differential expression of LdCsm and CTR, and the data supported the hypothesis. Strikingly, stepwise induction experiments indicated allowing diffusion of LdCsm effector led to massive chromosomal DNA degradation, suggesting this unique IIIA system can facilitate infection abortion to eliminate virus-infected cells.
The effects of palbociclib in combination with radiation in preclinical models of aggressive meningioma
Authors: Horbinski Craig , Xi Guifa , Wang Yufen , Hashizume Rintaro , Gopalakrishnan Mahesh , Phillips Joanna J , Houghton Peter , James Charles D , Kalapurakal John A 
Published: June 2021

AbstractBackgroundMeningiomas are the most common tumor arising within the cranium of adults. Despite surgical resection and radiotherapy, many meningiomas invade the brain, and many recur, often repeatedly. To date, no chemotherapy has proven effective against such tumors. Thus, there is an urgent need for chemotherapeutic options for treating meningiomas, especially those that enhance radiotherapy. Palbociclib is an inhibitor of cyclin-dependent kinases 4 and 6 that has been shown to enhance radiotherapy in preclinical models of other cancers, is well-tolerated in patients, and is used to treat malignancies elsewhere in the body. We, therefore, sought to determine its therapeutic potential in preclinical models of meningioma.MethodsPatient-derived meningioma cells were tested in vitro and in vivo with combinations of palbociclib and radiation. Outputs included cell viability, apoptosis, clonogenicity, engrafted mouse survival, and analysis of engrafted tumor tissues after therapy.ResultsWe found that palbociclib was highly potent against p16-deficient, Rb-intact CH157 and IOMM-Lee meningioma cells in vitro, but was ineffective against p16-intact, Rb-deficient SF8295 meningioma cells. Palbociclib also enhanced the in vitro efficacy of radiotherapy when used against p16-deficient meningioma, as indicated by cell viability and clonogenic assays. In vivo, the combination of palbociclib and radiation extended the survival of mice bearing orthotopic p16 deficient meningioma xenografts, relative to each as a monotherapy.ConclusionsThese data suggest that palbociclib could be repurposed to treat patients with p16-deficient, Rb-intact meningiomas, and that a clinical trial in combination with radiation therapy merits consideration.
Analysis of morphological characteristics of IDH-mutant/wildtype brain tumors using whole-lesion phenotype analysis
Authors: Snyder James M , Huang Raymond Y , Bai Harrison , Rao Vikram R , Cornes Susannah , Barnholtz-Sloan Jill S , Gutman David , Fasano Rebecca , Van Meir Erwin G , Brat Daniel , Eschbacher Jennifer , Quackenbush John , Wen Patrick Y , Lee Jong Woo 
Published: June 2021

Abstract

Background
Although IDH-mutant tumors aggregate to the frontotemporal regions, the clustering pattern of IDH-wildtype tumors is less clear. As voxel-based lesion-symptom mapping (VLSM) has several limitations for solid lesion mapping, a new technique, whole-lesion phenotype analysis (WLPA), is developed. We utilize WLPA to assess spatial clustering of tumors with IDH mutation from The Cancer Genome Atlas and The Cancer Imaging Archive.

Methods
The degree of tumor clustering segmented from T1 weighted images is measured to every other tumor by a function of lesion similarity to each other via the Hausdorff distance. Each tumor is ranked according to the degree to which its neighboring tumors show identical phenotypes, and through a permutation technique, significant tumors are determined. VLSM was applied through a previously described method.

Results
A total of 244 patients of mixed-grade gliomas (WHO II–IV) are analyzed, of which 150 were IDH-wildtype and 139 were glioblastomas. VLSM identifies frontal lobe regions that are more likely associated with the presence of IDH mutation but no regions where IDH-wildtype was more likely to be present. WLPA identifies both IDH-mutant and -wildtype tumors exhibit statistically significant spatial clustering.

Conclusion
WLPA may provide additional statistical power when compared with VLSM without making several potentially erroneous assumptions. WLPA identifies tumors most likely to exhibit particular phenotypes, rather than producing anatomical maps, and may be used in conjunction with VLSM to understand the relationship between tumor morphology and biologically relevant tumor phenotypes.
Successful Treatment of Persistent Coronavirus Disease 2019 Infection in a Patient With Hypogammaglobulinemia With REGN-COV2: A Case Report
Authors: Luitel Pankaj , Vais Dana , Gidron Adi 
Published: June 2021

Abstract
A 55-year-old man with hypogammaglobulinemia due to previous rituximab treatment developed persistent coronavirus disease 2019 pneumonia. Treatment with REGN-COV2 (casirivimab and imdevimab) resulted in the clearance of the infection. Targeted antiviral antibodies may be an important weapon in the management of immunocompromised patients infected with severe acute respiratory syndrome coronavirus 2 who fail to mount an immune response.
Sea ice and local weather affect reproductive phenology of a polar seabird with breeding consequences
Authors: Sauser Christophe , Delord Karine , Barbraud Christophe 
Published: June 2021

AbstractBreeding at the right time is essential for animals living in seasonal environments to ensure that energy requirements for reproduction, especially the nutritional needs for rearing offspring, coincide with peak food availability. Climate change is likely to cause modifications in the timing of maximum food availability, and organisms living in polar environments where the breeding period is heavily contracted may be particularly affected. Here we used a 26-year dataset to study the phenological response of a pagophilic species, the Snow Petrel (Pagodroma nivea), to climate change and its demographic impact. First, we investigated the trends and relationships between climate variables and hatching dates measured in three neighboring colonies. In a second step, we examined the impact of the hatching date and environmental covariates on the fledging probability. Our results showed that sea ice, a climate-related variable, showed a positive temporal trend. We found that hatching date was delayed when sea ice concentration was greater and local weather conditions were worse (i.e., increase in the number of windy days or the number of snow days). Hatching date had a negative effect on fledging probability, and fledging probability showed a bell-shaped temporal trend. We suggest that Snow Petrels can delay breeding phenology in response to environmental conditions. However, this plasticity may be limited as fledging success decreased with delayed hatching, potentially making the Snow Petrel vulnerable to a mismatch between resource availability and nutritional needs.
Experiences of Patient-Led Chronic Pain Peer Support Groups After Pain Management Programs: A Qualitative Study
Authors: Farr Michelle , Brant Heather , Patel Rita , Linton Myles-Jay , Ambler Nicholas , Vyas Sareeta , Wedge Hannah , Watkins Sue , Horwood Jeremy 
Published: June 2021

Abstract

Objective
A qualitative study of patients’ experiences and the impacts of peer support groups that patients maintained after UK NHS group pain management programs (PMPs).

Design
Long-term impacts of group PMPs remain unclear, with indications that positive effects can fade. We evaluated a model of continued peer support, co-produced by patients and clinicians, to maintain the therapeutic impact of PMP groups. A protocol was implemented that encouraged patients to continue to meet in their established PMP group for patient-led peer support (without clinical input) after PMPs finished. Peer support aimed to consolidate self-management, and advance social life recovery. We examined the impacts that groups had on attendees, and why some dropped out.

Methods
Semi-structured interviews with 38 patients and 7 clinicians, analyzed thematically.

Results
Friendship bonds and mutual understandings of effective ways of coping with pain encouraged participants to maintain recovery following PMPs. After PMP professional involvement has ended, these meetings enabled patients to develop greater agency from the shared sense of helping bring about new achievements or averting setbacks. Peer support extended the understanding of what is possible when living with pain. However, continuing meetings were not right for all. Reasons for not attending included lack of connection with peers.

Conclusions
Co-produced peer support groups after PMPs can be a low-cost, effective social intervention, providing emotional, practical and social benefits, with improved self-management skills, stronger social connections and some reduced use of health services. Project resources for developing peer support meetings after PMPs are freely available online.
Balancing the Deontological and Utilitarian Values of Inter-Institutional Management: The Case of Urban Policing
Authors: Yuval Fany , Porat Irit 
Published: June 2021

Abstract
Inter-institutional management struggles to balance the deontological and utilitarian values of public services. Urban policing exemplifies this subtle balance between the different yet complementary authorities and tools entrusted to municipalities and the police to ensure personal and environmental safety, and tackle the nuisances that negatively impact residents’ quality of life. Hence, democracies adopt different approaches to managing the interplay between municipalities and the police. Integrating the public value accounting, strategic triangle, and PerformanceStat approaches, we analyse the effective inter-institutional management of the local authorities and the police using three models of urban policing that currently exist in Israel. Based on in-depth interviews, we suggest an improved strategy that balances deontological and utilitarian values, and should result in financial savings, less need to use authority and force, sensitive enforcement services, and value for local residents.
Governors in Control: Executive Orders, State-Local Preemption, and the COVID-19 Pandemic
Authors: Weissert Carol S , Uttermark Matthew J , Mackie Kenneth R , Artiles Alexandra 
Published: June 2021

AbstractThe nation’s governors took strong and decisive action in responding to the 2020 COVID-19 pandemic, often directly affecting their local governments. These actions allow us to examine this question: Will governors’ actions in an unprecedented emergency situation centralize the authority of the state or rely on local governments to deal with localized problems? Additionally, what factors affect those decisions? We examine all governors’ executive orders affecting local governments in the first five months of the 2020 pandemic. We find that preemption did occur, especially in the early months of the pandemic. States that gave their localities more autonomy were associated with preemption throughout the pandemic; the governor’s party affiliation and her ideological match with local officials were associated with greater preemption in some phases of the pandemic but not others.