bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvement of community human resources through education in the Muhammadiyah Sedati branch
Authors: Salsabila Salsabila , Hikmah Nurul , Jariyah Ainun , Feronika Beta , Tyas Tyas 
Published: August 2021

Tujuan penelitian ini untuk mengetahui peningkatan SDM masyarakat melalui penidikan yang ada di cabang Muhammadiyah Sedati. Penelitian ini merupakan penelitian deskriptif . penelitian ini hanya mendeskripsikan dalam bentuk wawancara, observasi dan dokumen .Dalam penelitian ini, peneliti menggunakan teknik pengumpulan data dalam bentuk wawancara secara langsung kepada PCM Sedati , Sekolah Muhammadiyah 1 Sedati dan Anggota Muhammadiyah masjid Al-islam Sedati. Berdasarkan hasil penelitian, cabang Muhammadiyah di Sedati sudah berdiri sejak lama. Dalam mendirikan cabang Muhammadiyah di Sedati ini, tentu banyak sekali halangan dan rintangan serta konflik antar masyarakat setempat. Akan tetapi, dengan usaha dan do’a semua bisa berjalan dengan lancar. Perkembangan Muhammadiyah di Sedati pun begitu pesat, banyak sekali strategi dakwah yang dilakukan oleh cabang Muhammadiyah di Sedati dalam mengembangkan perserikatan Muhammadiyah. Dengan adanya ranting Muhammadiyah, memudahkan akses dalam berdakwah. ada 5 ranting muhammadiyah di Sedati, yaitu : 1) Sedati Gede, 2) Sedati Agung, 3) Pabean, 4) Semampir, 5) Banjar Kemuning. Dalam hal pendidikan, Muhammadiyah sangat memprioritaskan pendidikan dalam strategi dakwahnya. Pendidikan sangat penting dikembangkan untuk mencetak generasi unggul, cerdas dan berakhlak mulia. Dengan adanya program Tahfidzul Qur’an di SD 1 Muhammafdiyah sedati merupakan program yang sangat baik serta banyak diminati oleh orang tua siswa, karena orang tua siswa menginginkan anaknya berprestasi dari segi keagamaan serta akademik. sekolah ini tidak hanya bekerjasama dengan lembaga yang bergerak di bidang pendidikan seperti Universitas Muhammadiyah Sidoarjo dan Kelompok Kerja Kepala Sekolah Se-Sedati ( K3S), akan tetapi bekerja sama dengan lembaga yang bergerak di bidang keamanan seperti Polsek dan Koranmil.
Energy-saving texnologies and alternative energy sources
Authors: Abdunabiyeva Noila Yusufjon qizi  
Published: August 2021

The energy problem is one of the most pressing issues in the world is on the agenda of scientists working in the field of energy. XXI century with the development of science, rising technology creating the opportunity for a person to live normally, providing him with enough energy, food is one of the key issues. Everyone knows digging the energy reserves of its resources are declining. But the need for it increased, and now the world's population has reached seven billion. There are the following types of energy sources that used by humanity: oil, coal, gas, atom, biomass, water, solar, wind, geothermal energy. This energy sources can be divided into two types, respectively. Biomass, water, sun, wind, geothermal energy - renewable; oil, coal, gas, nuclear energy - non-renewable. The energy from these resources is electricity, utilities such as energy consumed for services (heating of buildings, hot water supply) occurs in views.
Efforts To Reduce Downgrade Of Steel Pipes In The Production Process Using The HEART Method
Authors: Julianto Irfan Widya , Hana Catur Wahyuni  
Published: August 2021

Pt X is a company that produces steel pipe of various shapes and size. In the production procces not only using machines but also using humans as operators. So in this case humans play an important role in maintaining the quality of production. The purpose of this study is to analyze the human error probability with Human Error Assessment and Reduction Technique method (HEART). HEART is a method designed as a fast and simple human reliability assessment in quantifying the risk of human error. From this research, it was found that 3 tasks had a high HEP value which caused the decline in pipe quality during the production process, namely task 3.2, 4.1 and task 3.4. Which has the highest HEP value on task 3.2, namely setting the machine with a value of 0,7680. The cause is due to the lack of operator expertice and the center roll was not carried out when installing it, so that training is needed to increase operator expertice.
Clinical features and possible prognostic factors in patients with Marginal Zone Lymphoma: Retrospective analysis from two centers
Authors: Akyol Pınar , Yıldız Abdulkerim , Albayrak Murat , Yıldırım Murat , Tığlıoğlu Mesut , Sağlam Buğra , Maral Senem , Öztürk Hacer Berna Afacan , Aylı Meltem , Şahin Osman 
Published: August 2021

Abstract
Objectives

Marginal zone lymphoma accounts 5%-17% of all non-Hodgkin lymphomas and has an indolent clinical course. The parameters that predict prognosis and the need for treatment are still unclear. The aim of the current study was to examine the impact of parameters on the course of disease and the need for treatment in marginal zone lymphoma.
Methods

A retrospective study was conducted with marginal zone lymphoma patients in the two centres between 2010 and 2018. The demographic and disease characteristics, and also hematological and biochemical parameters at the time of diagnosis were examined. The effect of the parameters on overall survival and need for treatment were analyzed.
Results

During the follow-up, 25 patients required treatment and 15 patiens were followed up without treatment. Overall survival was significantly higher in patients with nodal marginal zone lymphoma than in extranodal and splenic marginal zone lymphoma patients. overall survival of patients who required treatment was 92.9 months while untreated patients was 58.4 months and there was no significant difference among the groups. The platelet count of untreated patients at the time of diagnosis were significantly higher than patients who received treatment. No significant relationship was found between any parameter and overall survival.
Conclusions

We demonstrated platelet count at the time of diagnosis as a predictive factor for future treatment need. It is an objective and simple blood test that may be helpful to predict the course of the disease although further studies are warranted.
Operando Investigation of the Locally Enhanced Electric Field Treatment (LEEFT) Harnessing Lightning-Rod Effect for Rapid Bacteria Inactivation
Authors: Wang Ting , Brown Devin k. , Xie Xing 
Published: August 2021

Abstract

The growth of undesired bacteria causes numerous problems. Here, we show that locally enhanced electric field treatment (LEEFT) can cause rapid bacteria inactivation by electroporation without any side reactions. The bacteria inactivation is studied in situ at the single-cell level on a lab-on-a-chip that has nanowedge-decorated electrodes. Rapid bacteria inactivation occurs specifically at nanowedge tips where the electric field is enhanced due to the lightning-rod effect. The mechanism study shows that the bacteria inactivation is caused by electroporation induced by the locally enhanced electric field. The bacteria inactivation performance depends on the strength of the enhanced electric field instead of the applied voltage, and no ROS generation is detected when >90% bacteria inactivation is achieved. Quick membrane pore closure under moderate LEEFT indicates that electroporation is the predominant mechanism. LEEFT only requires facile treatment to achieve bacteria inactivation, which is safe for treating delicate samples and energy-efficient for large scale applications. The findings in this work can provide strong supports for the future applications of LEEFT.
Analytical Prediction for Quasi-TE mode in Silicon Nanowire Optical Rectangular Waveguide
Authors: SINGH RITU RAJ , Priye Vishnu 
Published: August 2021

Abstract
Theoretical and numerical mode estimation performed on Silicon Nanowire Optical Rectangular Waveguide (SNORW) is presented for on-chip communication in photonic integrated circuits. The propagation behavior of electric and magnetic fields is investigated, where zeroth order mode is found dominating inside the nanoslot region of SNORW for the circularly symmetric quasi-TE mode to propagate. This SNORW structure supports hybrid mode, which derives its behavioral root from the rectangular waveguide and functional root from the slot waveguide. In periodic silicon nanowire-based waveguide, it is found that the envelope of mode field intensity closely matches with rectangular waveguide and the guiding properties closely matches with slot waveguide. The type of mode is analyzed by full vectorial Finite Element Method (FEM) and the analytical expression is derived using Effective Index Method (EIM). Analytical expressions are used to express Quasi-TE mode in term of material profile and waveguide physical parameters. The results obtained for SNORW in S, C and L wavelength bands are compared with the earlier reported work on slot waveguide, and the field intensity obtained with the theoretical equations is also compared with that of FEM results.
Efficient in-depth analysis and optimum design parameter estimation of MEMS capacitive pressure sensor utilizing analytical approach for square diaphragm
Authors: JINDAL SUMIT KUMAR , PATEL ISHAN , SETHI KRISH , KAUL SIMRIT , K SREEKANTH P , Kumar Ajay 
Published: August 2021

Abstract
Capacitive pressure sensors have become more popular as compared to piezoresistive pressure sensors as they yield superior sensitivity and lesser non-linearity. Efficient analysis for modelling capacitive pressure sensors is thus increasingly becoming more important due to their innumerable use cases. The higher sensitivity of square diaphragm for the same side length in comparison to circular diaphragm makes it ideal for sensor design. In this work, a complete formulation for analysis of capacitive pressure sensor with the square diaphragm in normal and touch mode operation has been presented as these two modes are established operating modes for these sensors. A comprehensive study of sensor parameters like capacitance, diaphragm deflection, capacitive and mechanical sensitivity has been formulated to aid the choice of sensor characteristics. This work also focuses on the method to determine core design parameters for optimal operation. Computationally complex methods have been used in the past for analysis of square diaphragms. In contrast to the finite element system, the analytical technique proposed in this study is less complex and computationally efficient (FEM). The results were computed and simulated using MATLAB.
Introducing an Efficient Socio-Economically Oriented Data Envelopment Analysis Method for Selecting the Optimum Groundwater Dam Site Location
Authors: Maghsoudy Soroush , Fathianpour Nader 
Published: August 2021

Abstract
Groundwater dams are commonly constructed in arid and semiarid regions for subsurface storage of water. In this study, an attempt is made to present a new efficiency-based site selection methodology for constructing groundwater dams based on socio-economic approaches. The site selection process was conducted in a semiarid region in Central Iran. A total of 13 different criteria in four major classes of climate, geology, hydrology, and socio-economy were defined. Nine multi-criteria decision making (MCDM) methods were used for site selection, followed by integrating the results by Borda and Copeland algorithms. The data envelopment analysis (DEA) was employed for selecting the optimum groundwater dam site from the same choices. The DEA method is based on efficiency and it is capable for evaluating the performance of each alternative. Four different scenarios, including the CCR-Input, CCR-Output, BCC-Input, BCC-Output, were used to implement the DEA approach. In addition, the socio-economic-based optimization equation was solved by considering three socio-economic criteria as the output of the DEA model. The results show that the CCR method provides the best results for groundwater dam site selection by maximizing the outputs. Two algorithms, namely the Potential Improvement and Input/output contribution, were used to evaluate the performance of each alternative. These algorithms show the amount of improvement for each selected option. The application of the DEA method, as a new approach for groundwater dam site selection, can increase the performance of the selected option and facilitate dam maintenance throughout its operation time.
Oxidative Stress Induced by Exposure of Microplastics in Labeo Rohita
Authors: Jandu Rajinder Singh , Vashishat Nisha 
Published: August 2021

Abstract
The present study revealed the oxidative stress induced by the exposure of low density polyethylene microplastics (LDPE MPs) in Labeo rohita. Fingerlings were divided into four (control, T1, T2 and T3) groups. Fingerlings of T1, T2 and T3 groups were exposed respectively to 2, 20 and 200 mg/L of LDPE MPs for 45 days. A control was also maintained during experiment to which no MPs were added. Oxidative stress studies revealed a decrease in the activity of hepatic antioxidative enzymes i.e. superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and glutathione reductase (GR) in all treated groups in dose and time dependent manner. In gills, an increase in the activities of SOD, CAT and GPx but decrease in the activities of GR and GST was found in T1 group after 30 days of exposure. However, decrease in activities of these enzymes was observed in all treated groups in dose dependent manner after 45 days of exposure. Moreover, the activities of antioxidative enzymes were found to be decreased in time dependent manner. In kidneys, increase in the activities of antioxidative enzymes was observed in T1 group followed by their decrease in T2 and T3 groups in dose and time dependent manner. However, Lipid peroxidation was found to be increased in vital organs of all treated groups in dose and time dependent manner indicating MPs induced oxidative stress in these organs due to increased production of reactive oxygen species.
Identification and Characterization of Circular RNAs in Brassica rapa in Response to Plasmodiophora brassicae
Authors: Liu Huishan , Nwafor Chinedu Charles , Piao Yinglan , Li Xiaonan , Zhan Zongxiang , Piao Zhongyun 
Published: August 2021

Abstract

BackgroundPlasmodiophora brassicae is a soil-borne pathogen that attacks the roots of cruciferous plants, causing clubroot disease. CircRNAs are non-coding RNAs widely exist in plant and animal species which can acting as “microRNA (miRNA) sponges” and “competing endogenous RNAs (ceRNAs)”. Knowledge of circRNAs has been updated continuously and rapidly. However, the information about circRNAs in the regulation of clubroot-disease resistance is limited in Brassica rapa. ResultsHere, the Chinese cabbage (BJN 222) containing clubroot resistance gene (CRa) resistant to the Pb4 was susceptible to the PbE of P. brassicae. To investigate the mechanism of cicRNAs responsible for clubroot-disease resistance in Brassica rapa, the circRNA-seq was performed roots of BJN 222 at 0 d, 8 d, and 23 d after inoculated with Pb4 and PbE. A total of 1636 circRNAs were detected distributed on 10 chromosomes. Furthermore, total 231 differentially expressed circRNAs between groups were screened. Parental genes of circRNAs functions analysis results indicated that the expression of circRNAs was affected not only by inoculation time but also by the pathogenicity of P. brassicae. However, the “Phenylalanine, tyrosine, and tryptophan biosynthesis” pathway was significant enriched between the two pathotypes at different inoculation times. All the expression of target genes annotated with “receptor-like protein kinase,” “zinc finger protein,” “LRR-repeat protein,” and “hormone-related” identified from the circRNA-miRNA-mRNA network were analyzed. 5 target genes were consistent with the expression pattern of novel_circ_000495 at 8 dpi, but only Bra026508 was significantly up-regulated. ConclusionThe up-regulated novel_circ_000495 might suppressed the expression of miR5656-y, leading to the up-regulation of Bra026508. Our results provided new insights to clubroot resistance mechanisms of B.rapa and laid a foundation for further research on the function of circRNAs responsible for the pathogen infection.
Segmental Strain for Scar Detection in Acute Myocardial Infarcts and in Follow-up Exams using Non-Contrast CMR Cine Sequences
Authors: Polacin Malgorzata , Karolyi Mihaly , Eberhard Matthias , Matziris Ioannis , Alkadhi Hatem , Kozerke Sebastian , Manka Robert 
Published: August 2021

Abstract
Background The purpose of the study was to investigate feasibility of infarct detection in segmental strain derived from non-contrast cardiac magnetic resonance (CMR) cine sequences in patients with acute myocardial infarction (AMI) and in follow-up (FU) exams.Methods57 patients with AMI (mean age 61 ± 12 years, CMR 2.8 ± 2 days after infarction) were retrospectively included, FU exams were available in 32 patients (35 ± 14 days after first CMR). 28 patients with normal CMR (47 ± 8 years) served as controls. Dedicated software (Segment CMR, Medviso) was used to calculate global and segmental strain derived from cine sequences. Cine short axis stacks and segmental circumferential strain calculations of every patient and control were presented to two blinded readers in random order, who were advised to identify potentially infarcted segments, blinded to LGE and clinical information. Results Impaired global strain was measured in AMI patients compared to controls (global peak circumferential strain [GPCS] p= 0.01; global peak longitudinal strain [GPLS] p= 0.04; global peak radial strain [GPRS] p= 0.01). In both imaging time points, mean segmental peak circumferential strain [SPCS] was impaired in infarcted tissue compared to remote segments (AMI: p=0.03, FU: p=0.02). SPCS values in infarcted segments were similar between AMI and FU (p=0.8), remote segments were marginally more impaired in AMI than in FU (p= 0.07). In SPCS calculations, 141 from 189 acutely infarcted segments were accurately detected (74.6%), visual evaluation of correlating cine images detected 44.4% infarcts. In FU, 81.5 % infarcted segments (93/114 segments) were detected in SPCS and 51.8% by visual evaluation of correlating short axis cine images (p=0.01).ConclusionSegmental circumferential strain derived from routinely acquired native cine sequences detects nearly 75 % of acute infarcts and about 80% of infarcts in subacute follow-up CMR, significantly more than visual evaluation of correlating cine images alone. Acute infarcts may display only subtle impairment of wall motion and no obvious wall thinning, thus SPCS calculation might be helpful for scar detection in patients with acute infarcts, when only cine images are available.
Level of Hypertension Treatment Adherence During COVID-19 Pandemic
Authors: Petkova Valentina , Andreevska Kalina , Hristov Emil , Grekova Daniela , Todorova Anna , Tsvetkova Antoaneta , Dimitrov Milen 
Published: August 2021

Abstract
Background:Arterial hypertension is prevalent and remains one of the most significant causes of mortality worldwide. Over 1.7 million Bulgarians (24%) have a blood pressure (BP) value equal to or higher than 140/90 mmHg and therefore are at increased risk of complications. Adherence to antihypertensive medications is the cornerstone for achieving hypertension control. Methods:The aim of this study was to assess whether the patients of both sexes with hypertension exhibit equal adherence to medication during the COVID-19 pandemic and to explore how the pandemic has affected the adherence of patients with high BP to prescribed antihypertensive drugs. This multicentre observational study utilized self-completed questionnaires among patients visiting several healthcare centres, including the cardiology outpatient clinic of a university hospital, a private cardiology practice, general practice offices, and a pharmacy between June and November 2020. Results:Overall, 442 patients were included in the study. The likelihood of adherence was assessed using the 5‐item version of the Medication Adherence Report Scale (MARS-5©Professor Rob Horne). The average MARS score of the sample was 16.81, the median was 4.162, and the most common value was 3 (24.5% of respondents).Conclusions:Overall, 18.1% had a high degree of adherence to the prescribed therapy, and almost 1/3 of the respondents (30.7%) had a low degree of adherence to the prescribed therapy. In the present study, approximately one-third of the participants complied with pharmacological treatment. The study suggests that several sociodemographic factors but not the COVID pandemic play a role in treatment adherence.
De-ubiquitination of SAMHD1 by USP7 overcomes oncogenic stress and contributes to chemotherapy insensitivity
Authors: Liu Jingwei , Zhou Tingting , dong xiang , Guo Qiqiang , Zheng Lixia , Wang Xiaoxun , Zhang Naijin , Danni Li , Ren Ling , Yi Fei , Zhang Ying , Li Zi-wei , Wang Xi-wen , deng chengsi , Li Chunlu , Xu Hongde , Guan Yi , Li Xiaoman , Yu Yang , Guo Wendong , Wang Zhuo , Jiang Bo , Wu Xuan , Bai Ning , Feng Yanling , Ma Mengtao , Kong Qingquan , Wei Jiayi , Wang Zhenshuang , Li Hao , Song Xiaoyu , Xing Chengzhong , Cao Liu 
Published: August 2021

Abstract
Oncogenic stress induces DNA damage response (DDR) that guards against genetic instability during the evolution of cancer. SAMHD1, a dNTPase protecting cells from viral infections, has been recently found to participate in DNA damage repair process. However, its role in tumorigenesis remains largely unknown. Here, we show that SAMHD1 is up-regulated in early-stage human carcinoma tissues and cell lines under oxidative stress or genotoxic insults. We further demonstrate that de-ubiquitinating enzyme USP7 interacts with SAMHD1 and de-ubiquitinates it at lysine 421, thus stabilizing SAMHD1 protein expression, and promotes tumor cell survival under genotoxic stress. Furthermore, SAMHD1 levels positively correlates with USP7 in various human carcinomas, and is associated with an unfavorable survival outcome in patients who underwent chemotherapy. Moreover, USP7 inhibitor sensitizes tumor cells to chemotherapeutic agents by decreasing SAMHD1 in vitro and in vivo. These findings suggest that targeting USP7 may help overcome chemoresistance, thus necessitating further investigation in the pursuit of precision medicine.
T1T2 Mapping and Texture Analysis of Cine and T2-weighted Magnetic Resonance Imaging to Detect Myocardial Tissue Changes Associated with Chronic Kidney Disease
Authors: Amano Yasuo , Omori Yuko , Amano Maki , Ando Chisato , Shinoda Naoki , Suzuki Yasuyuki , Matsumoto Naoya 
Published: August 2021

Abstract
Myocardial tissue changes associated with chronic kidney disease (CKD) may lead to heart failure, serious ventricular arrhythmia, and sudden cardiac death. Here, we sought to determine usefulness of T1T2 mapping and texture analysis of T2-weighted short inversion time inversion recovery (STIR) and cine imaging to detect myocardial changes associated with CKD. We examined 34 patients with CKD and 10 controls using a 1.5 T system. T1 and T2 values of the septal myocardium were significantly greater in patients than in controls (P = 0.021 for T1 and P < 0.01 for T2). The open-access texture analysis software, including features reduction methods, selected one particular feature for T2-weighted STIR and another for cine imaging: vertical fraction for STIR and horizontal short-run emphasis for cine imaging, which were significantly lower in the patients with CKD than in the controls (P < 0.01 for both). Texture analysis was not significantly better than T1T2 mapping in detecting the myocardial tissue changes, whereas STIR suffered from image artifacts in 9 patients. In conclusion, additional T1T2 mapping or postprocessing texture analysis may be feasible for detection of myocardial tissue changes associated with CKD.