bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medication-related Knowledge, Administration Practice and Adherence Among Caregivers of Chronically Ill Children in Malaysia
Authors: Chew Chii-Chii , Chan Huan-Keat , Chang Chee-Tao , HSS Amar-Singh , HASSALI Mohamed azmi 
Published: March 2021

Abstract
Background: Caregivers’ knowledge, practice and adherence in medication administration who care for children with chronic illness requiring long-term pharmacological treatments are factors associating with children medication safety at home. This study aimed to determine the medication-related knowledge, administration practice and adherence among caregivers of chronically ill children in Malaysia. Methods: This cross-sectional study was conducted at the paediatric outpatient clinic of a tertiary public hospital. Caregivers of chronically ill children, who engaged in medication administration at home for at least 3 months, were conveniently recruited. Their medication-related knowledge and administration practice were evaluated based on a checklist, while their adherence to medication administration was assessed using a validated 5-point scale. The associated factors were also explored. Findings: Of the 141 participants, most were mothers (90.8%) and had a full-time job (55.3%). Most of them had adequate medication-related knowledge (71.6%) and an appropriate administration practice (83.0%). The majority of them (83.0%) also rated themselves as adherent to medication administration. The participants with a child above 5 years of age (91.2%) were found to have a better practice than those with younger children (75.3%) in medication administration (p=0.012). However, those with a child taking two (adjusted OR: 12.53) or three (adjusted OR: 8.29) medications, getting their refills from private health institutions apart from this hospital (adjusted OR=7.06) and having multiple illnesses (adjusted OR=21.25) were more likely to be not adherent to medication administration. Conclusion: Caregivers of chronically ill children in Malaysia generally have sufficient knowledge and an appropriate practice of medication administration at home. Yet, strategies to improve the adherence to medication administration, particularly in those who care for children with complicated health conditions, are warranted.
WITHDRAWN: Surgical Resection of a Presacral Solitary Fibrous Tumor with Extension to Iliac Vessels using Karakousis’s Abdominoinguinal Approach: Report of a Rare Case
Authors: Pachajoa Diana A. Pantoja , Huatuco René M. Palacios , Sambuelli Gabriela , Viscido Germán , Doniquian Alejandro M. , Mandojana Facundo 
Published: March 2021

Abstract

Background: The solitary fibrous tumor (SFT) is a rare tumor of mesenchymal origin, with a reported incidence of 2.8 cases per 100.000 tumors and with distinctive histopathological and immunohistochemical characteristics. It was initially described as a pleural lesion and subsequently, it was found in different organs and tissues. The abdominoinguinal incision described by Karakousis allows a radical reliable approach for abdominal-pelvic tumors in lower quadrants. We present the case of a patient with a presacral STF extending to iliac vessels, which required the Karakouis’s approach for its surgical resection.Case Presentation: Forty-seven-year-old man with pain in lumbosacral region radiating to left leg since 5 months. MRI and CT show evidence of a 10cm-retroperitoneal mass (presacral space) extending to left iliac vessels. The early diagnosis corresponded to a sarcomatous retroperitoneal tumor. It was decided to carry out the abdominal scan through the Karakousis’s approach for surgical resection with permanent neurovascular control. The immunohistochemistry and histopathological study revealed a CD-34 positive spindle-cell neoplasia, vimentin, Bcl-2, and β-catenin, compatible with a SFT. It was categorized as low risk for developing metastasis and death from disease, according to the new criteria for malignancy. At present, the patient is asymptomatic and disease-free at 17 months after surgery.Conclusion: Presacral SFT is a rare entity, with a scant incidence reported regarding this location and long-term treatment. Surgical resection is needed as the immediate treatment.
Role of Fzd6 in Regulating the Osteogenic Differentiation of Adipose-derived Stem Cells in Osteoporosis
Authors: Wu Tianli , Yao Zhihao , Tao Gang , Lou Fangzhi , Tang Hui , Gao Yujin , Yang Xiaojuan , Xiao Jingang 
Published: March 2021

Abstract
Objective: Although it has been demonstrated that adipose-derived stem cells (ASCs) from osteoporosis mice (OP-ASCs) exhibit impaired osteogenic differentiation potential, the molecular mechanism has not yet been elucidated. We found that Fzd6 was decreased in OP-ASCs compared with ASCs. This study investigates the effects and underlying mechanisms of Fzd6 in the osteogenic potential of OP-ASCs. Methods: Fzd6 expression in ASCs and OP-ASCs was measured by PCR gene chip. Fzd6 overexpression and silencing lentiviruses were used to evaluate the role of Fzd6 in the osteogenic differentiation of OP-ASCs. Real-time PCR (qPCR) and western blotting (WB) was performed to detect the expression of Fzd6 and bone-related molecules, including runt-related transcription factor 2 (Runx2) and osteopontin (Opn). Alizarin red staining and Alkaline phosphatase (ALP) staining was performed following osteogenic induction. Microscopic CT (Micro-CT), hematoxylin and eosin staining (H&E) staining, and Masson staining were used to assess the role of Fzd6 in osteogenic differentiation of osteoporosis (OP) mice in vivo.Results: Expression of Fzd6 was decreased significantly in OP-ASCs. Fzd6 silencing down-regulated the osteogenic ability of OP-ASCs in vitro. Overexpression of Fzd6 rescued the impaired osteogenic capacity in OP-ASCs in vitro. We obtained similar results in vivo.Conclusions: Fzd6 plays an important role in regulating the osteogenic ability of OP-ASCs both in vivo and in vitro. Overexpression of Fzd6 associated with the Wnt signaling pathway promotes the osteogenic ability of OP-ASCs, which provides new insights for the prevention and treatment of OP.
N-acetylcysteine promotes osteogenic differentiation in periodontal ligament stem cells under cyclic mechanical stretch
Authors: Xi Xun , Li Zixuan , Zhao Yi , Liu Hong , Chen Shuai , Liu Dongxu 
Published: March 2021

Abstract
Background

Biomechanical forces are vital for the regulation of skeletal tissue. Mechanical stretch plays a vital role in osteogenic differentiation of periodontal ligament stem cells (PDLSCs) during orthodontic treatment. Cyclic mechanical stretch may trigger the up-regulated production of reactive oxygen species (ROS). ROS has a critical effect on bone cell function and the pathophysiology of bone diseases. N-acetylcysteine (NAC), a ROS scavenger, possesses powerful antioxidant capacity. The aim of this study was to determine the role of ROS and NAC in PDLSCs during osteogenic differentiation under cyclic mechanical stretch. We further investigated that the therapeutic potential of NAC to improve the changes of the microstructure of alveolar bone during orthodontic tooth movement in rats by micro-CT system.
Methods

The expression of COL1 (collagen type I), RUNX2 (runt-related transcription factor 2) and OPN (osteopontin) by qRT-PCR and Western blot experiments, and alkaline phosphatase (ALP) staining as well as ALP activity tests were used to examine osteogenic differentiation tendency of PDLSCs subjected to cyclic mechanical stretch of 10% and 0.5Hz deformation induced by the Flexcell tension system. ROS production in PDLSCs were measured under cyclic mechanical stretch by Flow Cytometry. The levels of reduced glutathione (GSH), oxidized GSH (GSSG) and the GSH/GSSG ratio with or without NAC treatment were analyzed. And we evaluated the changes of the microstructure of alveolar bone during orthodontic tooth movement in rats employing micro-CT system.
Results

NAC treatment could promote the osteogenic differentiation of PDLSCs under cyclic mechanical stretch. Down-regulated ROS generation and the up-regulated level of GSH and the ratio of GSH/GSSG in PDLSCs treated with NAC were observed in response to cyclic mechanical stretch. NAC improved the microstructure of alveolar bone, including BV/TV (bone volume/total volume), Tb.Th (trabecular thickness), Tb.Sp (trabecular separation) and SMI (microstructure model index), during orthodontic tooth movement in rats.
Conclusion

These results revealed that NAC might be a potential therapeutic approach for the remodeling of the alveolar bone during orthodontic tooth movement.
Transcription shifts in gut bacteria shared between mothers and their infants: data from the NiPPeR Study
Authors: Vatanen Tommi , Sakwinska Olga , Wilson Brooke , Combremont Severine , Cutfield Wayne , Chan Shiao-Yng , Godfrey Keith , O’Sullivan Justin 
Published: March 2021

Abstract
The infant gut microbiome contains a portion of bacteria that originate from the maternal gut. In the infant gut these bacteria encounter a new metabolic environment that differs from the adult gut, consequently requiring adjustments in their activities. We utilized community RNA sequencing data (metatranscriptomes) from ten mother-infant dyads participating in the NiPPeR Study to characterize bacterial gene expression shifts following mother-to-infant transmission. Maternally derived bacterial strains adapted by large scale gene expression shifts following the transmission to the infant gut, with 12,564 activated and 14,844 deactivated gene families, including 1,007 transferases and 85 bacteriophage genes. The implicated genes were most numerous and the magnitude shifts greatest in Bacteroides spp. This study demonstrates environment-dependent, strain-specific shifts in gut bacteria function and underscores the importance of metatranscriptomic analysis in microbiome studies.
Psicología organizacional crítica frente a los efectos del neoliberalismo cultural. Una problematización de aspectos prácticos y epistemológicos
Authors: Pineda Félix. A 
Published: March 2021

Este artículo analiza la problematización de los aspectos prácticos y epistemológicos relacionados con la configuración de una psicología ocupacional crítica y relevante en el contexto del neoliberalismo cultural. Utilizando un enfoque empírico inductivo y una estrategia de revisión bibliográfica fundamentada en el análisis crítico de enunciados teóricos y autores, sustenta que la psicología organizacional debe reforzar su carácter crítico y pluridisciplinario en el abordaje conceptual y metodológico de la realidad organizacional, sin conformarse con el estatuto de una disciplina profesionalmente más vinculada a los designios ideológicos del gerencialismo. El artículo concluye evaluando los desafíos de la psicología frente a las prácticas gerenciales que, en nombre de la sobreproducción, la eficiencia y el cambio intemperante, están siendo aprehendidas como una virtud en la narrativa empresarial moderna.
La herida racial en Francisco Moscoso Puello: la angustia del mulato
Authors: Santos Cueto Roque Diomedes 
Published: March 2021

Francisco Moscoso Puello (1885-1959) es un notable médico dominicano de la primera mitad del siglo xx. Hijo de migrante español y negra dominicana, escribió una serie de obras que influyeron en su momento a la sociedad letrada de Santo Domingo. Cultivador de diversos géneros, su práctica de escritura estuvo permeada por la búsqueda incesante de lo que llamó el alma o el carácter nacional del pueblo dominicano. Regularmente se le coloca dentro del pesimismo dominicano, corriente de pensamiento decimonónica que miró con desdén nuestra composición social y/o racial. En este caso, quien escribe es un mulato que reconoce la composición demográfica de este mestizaje entre blanco español y negra africana; pero su ideal de civilización es la blanquitud europea como la entiende Bolívar Echeverría. A partir del método hermenéutico ideado por Stephen M. North y aplicado a un corpus literario importante, se resume en este trabajo lo que hemos llamado la conciencia escindida o la angustia del mulato. Encontramos que, influenciado por el determinismo geográfico y racial propio a las ciencias sociales del siglo xix, Moscoso Puello realizó una práctica escrituraria con la intención de sobrellevar la angustia existencial de ser un mulato en un país mulato; aunque no como todos los mulatos dominicanos dado su acercamiento privilegiado con el mundo europeo a través de su formación académica.
Pemberdayaan Masyarakat melalui Pengelolaan Hutan Pinus di Kecamatan Linge Aceh Tengah
Authors: Siti Ikramatoun  , Khairulyadi  , Riduan  
Published: March 2021

This article aims to describe community empowerment through the management of the pine forest owned by PT Tusam Hutan Lestari in Linge District, Central Aceh. How the relationship between the community and PT Tusam Hutan Lestari as the owner of a pine forest management permit in Linge District. The approach used in this article is a qualitative method with a descriptive model. The informant was selected using a purposive technique and data sourced from observations, interviews, and literature studies. The results of this study indicate that community empowerment through pine forest management in Linge District had a positive impact on the community. Utilization of the company's production forest by the community has encouraged the emergence of community economic empowerment because the granting of land management permits and tapping of pine sap by the community is accompanied by mentoring by the company and provision of training and the formation of company partners. It also means that there is an economic exchange relationship between the company and the community, and this relationship is a mutually beneficial relationship between the community and the company.
Abstrak
Artikel ini bertujuan untuk mendeskripsikan tentang pemberdayaan masyarakat melalui pengelolaan hutan pinus milik PT Tusam Hutan Lestari di Kecamatan Linge Aceh Tengah. Selain itu, artikel ini juga berusaha melihat relasi sosial yang terbangun antara masyarakat dengan PT Tusam Hutan Lestari di Aceh Tengah sebagai pemilik izin pengelolaan hutan pinus yang ada di Kecamatan Linge. Pendekatan yang digunakan dalam artikel ini adalah metode kualitatif dengan model deskriptif. Penentuan informan dilakukan dengan teknik purposive dan data diperoleh dari hasil observasi, wawancara dan studi literatur. Hasil kajian ini menunjukkan bahwa Pemberdayaan masyarakat melalui pengelolaan hutan pinus di Kecamatan Linge telah memberikan dampak positif bagi masyarakat. Pemanfaatan hutan produksi milik perusahaan oleh masyarakat telah mendorong lahirnya pemberdayaan ekonomi masyarakat, karena pemberian izin pengelolaan lahan dan penyadapan getah pinus oleh masyarakat diiringi oleh pendampingan oleh perusahaan dan pemberian pelatihan serta pembentukan mitra kerja perusahaan. Hal ini berarti pula bahwa terdapat relasi pertukaran ekonomi antara perusahaan dan masyarakat, dan relasi tersebut merupakan relasi yang saling menguntungkan kedua belah pihak yaitu masyarakat dan perusahaan.
Pengembangan Kamus Bergambar Bahasa Arab untuk Siswa Kelas I, II, III Madrasah Ibtidaiyah
Authors: Fuad Saiful 
Published: March 2021

Dalam pembelajaran Bahasa Arab, kamus merupakan hal yang penting untuk membantu siswa memahami makna kosakata. Pemahaman kosakata tidak hanya tergantung pada terjemahan secara langsung akan tetapi membutuhkan pengilustrasian gambar agar pemahaman siswa semakin mudah, khususnya siswa yang baru mengenal Bahasa Arab. Media bantu berupa kamus diharap dapat membantu siswa mampu belajar secara mandiri.
Tujuan penelitian ini adalah untuk: (1) Mengembangkan kamus bergambar Bahasa Arab untuk Siswa kelas I, II, III Madrasah Ibtidaiyah dan, (2) Mendeskripsikan kelayakan produk pengembangan kamus bergambar Bahasa Arab Untuk siswa kelas I, II, III Madrasah Ibtidaiyah Sunan Kalijogo. Metode pengembangan yang digunakan dalam penelitian ini adalah mengacu pada model model R&D menurut Borg and Gall. Subjek uji coba produk dalam penelitian ini adalah siswa kelas I, II, III Madrasah Ibtidaiyah Sunan Kalijogo Malang. Jenis data dalam penelitian ini adalah data kuantitatif dan kualitatif. Sumber data yang diperoleh peneliti adalah (1) ahli media, (2) ahli materi, (3) guru pengajar Bahasa Arabdan (4) siswa kelas I, II, III Madrasah Ibtidaiyah Sunan Kalijogo Malang.
Hasil penelitian ini adalah: (1) kamus Bergambar Bahasa Arab yang berjudul â€œKamus Bergambar Bahasa Arab untuk Madrasah Ibtidaiyah Kelas I, II, IIIâ€ terdiri dari 23 bab yang telah di kelompokkan menurut tema dan juga kelas, serta kamus ini dilengkapi dengan kata mutiara yang memotivasi siswa dalam belajar dan (2) kelayakan kamus bergambar Bahasa Arab untuk Kelas I, II, III Madrasah Ibtidaiyah ini dinyatakan valid atau layak dengan rata â€“ rata persentase sebesar 86,35% dari ahli media, ahli materi, guru, dan siswa.
Dari hasil penelitian ini, dapat dikemukakan beberapa saran, yaitu: (1) siswa, diharapkan dapat menjadikan Kamus Bergambar Bahasa Arab ini sebagai alat bantu dalam memudahkan memahami kosakata â€“ kosakata Bahasa Arab. (2) guru Bahasa Arab agar memanfaatkan kamus bergambar Bahasa Arab ini sebagai media untuk meningkatkan motivasi belajar siswa, dan media bantu ajar di dalam kelas, (3) peneliti dan pengembang media lainnya, hendaknya media ini bisa diteliti kekurangannya, diperbaiki, ditambah, dan dikembangkan yang lebih baik lagi, dan (4) mahasiswa Program Studi Pendidikan Bahasa Arab, hasil penelitian ini dapat dijadikan bahan kajian untuk penelitian selanjutnya serta dapat dikembangkan dengan lebih baik lagi.
Foreign Direct Investment and Export Decisions of Vietnamese Enterprises
Authors: Anh Pham The 
Published: March 2021

This research quantifies the impact of foreign direct investment (FDI) on the export decisions of Vietnamese enterprises. To control the problem of sample selection bias, this study employs the Heckman model (1979) estimated for two equations on export participation and rate. Unlike previous researches, which mainly rely on one single proxy of FDI, this research adopts sensititivy analysis through the estimation of a model with two representative variables for FDI. It is indicated that FDI has a positive impact on the export decisions of Vietnamese enterprises. Nonetheless, FDI has an insignificant effect on the export rate of Vietnamese enterprises.
Avaliação da aceitação, crenças, percepção e nível de conhecimento parental acerca da vacina do Papilomavírus Humano
Authors: De Brito André Carneiro , Costa Wagner do Carmo , Carbonell Roberto Carlos Cruz , Ferreira Ana Iara Costa , Ribeiro Leila Braga , Nakashima Fabiana , Ticianeli José Geraldo , Da Fonseca Allex Jardim , Machado Luiz Fernando Almeida , Costa Bianca Jorge Sequeira 
Published: March 2021

Objetivo: Avaliar a aceitação, crenças, e nível de conhecimento dos pais de crianças e adolescentes, entre 9 e 14 anos, acerca da vacina contra o HPV. Métodos: Estudo observacional, descritivo, transversal, quantitativo, envolvendo 300 pais ou responsáveis de crianças e adolescentes entre 9 e 14 anos, realizado entre agosto de 2019 e dezembro de 2020, por meio da aplicação de um questionário semiestruturado. Resultados: Demonstraram associações estatisticamente significativas ser mulher e já ter ouvido falar em HPV (p=0,003), ser mulher e já ter ouvido falar sobre a vacina do HPV (p=<0,001), ter maior nível de escolaridade e vacinar seus filhos contra o HPV (p=<0,001), ter uma religião e acreditar que a vacinação estimularia o início precoce da vida sexual dos filhos (p=0,01) e pertencer às religiões evangélicas e Testemunha de Jeová e não vacinar os filhos contra o HPV (p=0,01). Conclusão: O maior nível de escolaridade dos pais e as crenças religiosas foram primordiais para a adesão à vacinação, ficando clara a necessidade de que os mecanismos de transmissão de informação existentes sejam revistos para que atinjam realmente seus propósitos junto a população de Boa Vista.
As campanhas contra o Influenza e seu caráter educacional: análise do material produzido em 2016
Authors: Souza Giovana Marcelino Stilben de , Rodrigues Mariana Peres , Santos Matheus Marques da Silva , Bento Leda Marcia Araujo , Sales Antônio 
Published: March 2021

O avanço das complicações desenvolvidas pelas doenças é notável, tanto no número crescente de mortes quanto no de internações, sendo o vírus Influenza um dos representantes dos causadores desses males. Dessa forma, buscam-se maneiras eficazes de prevenir doenças como a gripe; entre tais medidas estão lavar as mãos com frequência, não compartilhar determinados objetos e, como ação mais eficaz, a vacinação. Por tal motivo, o trabalho em que se baseia este artigo tem o objetivo de analisar os tipos de conteúdo presentes em materiais elaborados pelo Ministério da Saúde no Brasil para campanha de vacinação contra a gripe no ano de 2016. A pesquisa faz uso das categorias de análise prescritas por Antoni Zabala acerca das práticas de ensino e aprendizagem. No decorrer da análise foi observado que o modo como o material foi elaborado em 2016 e a forma como foram dispostos os conteúdos, imagéticos e textuais, podem influenciar a eficácia das campanhas de vacinação.
Movimento Body Positive no Instagram: reflexões sobre a estetização da saúde na sociedade neoliberal
Authors: Conde Thais Nascimento , Seixas Cristiane Marques 
Published: March 2021

Com o avanço das tecnologias de informação, as redes sociais estão inseridas diretamente no cotidiano dos indivíduos e refletem o modo como grupos e indivíduos constroem suas relações sociais, afetivas e laborais. Considerando que a percepção sobre os corpos é influenciada pelos canais de comunicação, este trabalho procura discutir o crescimento do movimento Body Positive (BoPo) em perfis do Instagram, tendo em vista a estetização da saúde e o efeito de influência e controle que são exercidos sobre a relação dos indivíduos com seus corpos. Para tanto, toma-se como referência a análise dos mecanismos neoliberais de controle e modulação de subjetividades marcados pela exigência de desempenho máximo e pela permanente concorrência consigo mesmo e com os outros. Procura-se apresentar uma reflexão crítica sobre a capacidade de captura dos mecanismos de controle em redes sociais que, em associação ao mercado capitalista, produzem novas roupagens para antigos dispositivos de poder.
Rekayasa Limbah Cangkang Pilla Ampullacea Sebagai Penyaring Air Rumahan Dengan Variasi Ketebalan
Authors: Bahtiar Ahmad Doni Mutiara 
Published: March 2021

Rekayasa cangkang keong sawah (Pilla Ampellacea) ini adalah upaya pemanfaaatan limbah cangkang keong sawah yang selama ini hanya dibuang begitu saja supaya mempunyai nilai lebih yang bermanfaat untuk masyarakat. Serta cangkang keong sawah mudah untuk diternakan dan hidup bebas di daerah tropis seperti di Indonesia. Penelitian ini mengusulkan sebuah gagasan baru menggunakan cangkah keoang sawah sebagai membrane penyaring air kran di perumahan untuk mengikat logam-logam yang berbahaya apabila dikonsumsi oleh manusia. Selain logam-logam yang berbahaya juga mengikat bakteri e-coli yang menyebabkan diare. Cangkang keong sawah tersebut dicuci dengan larutan asam asetat dan disikat sampai bersih. Kemudian di giling sampai berbentuk serbuk dan mengalami berbagai macam perlakuan sampai terbentuk membran saringan air. Penelitian ini sebagai awal untuk mengatahui kemampuan keefetifan cangkang keong sawah sebagai media untuk menyaring air dalam mengikat logam dan bakteri di air. Tentunya penelitian berikutnya akan tetap dilaksanakan untuk mengetahui seberapa kemampuan teknis dari kekuatan membran terhadap tekanan air.Untuk mengetahui membran yang efektif untuk menyaring air dari kran perumahan maka dilakukan variasi ketebalan membran yaitu 2,4,6,8 mm