bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construção da Escrita na Perspectiva do Estudante Protagonista / Construction of Writing from the Perspective of the Protagonist Student
Authors: Souza Alice Brito de , Marques Marilaine De Castro Pereira , Souza Eunice Brito de , Gabriel Aparecida Pacheco , Chaves Sidney Da Silva , Vizzer Marlize Reffatti Zinelli 
Published: August 2021

Resumo: Alfabetizar é mais que traçar letras, é um processo de construção sociocultural da criança, que ocorre de forma gradativa, de acordo com as condições pedagógicas ofertadas e o estágio de desenvolvimento em que se encontram. O objetivo geral da presente pesquisa foi apresentar alternativas pedagógicas, que podem favorecer a aprendizagem da criança na constituição da linguagem escrita na educação infantil. Os objetivos específicos foram: a) abordar a importância da Educação Infantil no que se refere a aprendizagem da escrita; b) apresentar o processo de construção da escrita pela criança; c) discorrer sobre alternativas pedagógicas de construção da escrita na Educação Infantil, nas quais os estudantes sejam protagonistas. A pesquisa foi realizada sob os métodos indutivo, bibliográfico e descritivo, no período de março a setembro de 2020. No processo de construção da escrita, os professores precisam valorizar o que as crianças possuem em cada fase da vida, ou seja, sua leitura de mundo; utilizar metodologias ativas, materiais concretos, contextualizar os objetos do conhecimento para tornar as aulas significativas; levar em conta aspectos afetivos, cognitivos e sociais, envolvidos na aprendizagem da escrita e propor atividades que estimulas o pensar e à geração de habilidades essenciais para formação integral. Contar história a uma criança, ou ainda ouvi-la recontar a história ouvida e ser professor escriba, são estratégias para colocar as crianças em contato com o mundo da leitura e da escrita. Não existe um receituário de práticas infalíveis, mas há princípios norteadores para se auxiliar os professores em suas escolhas metodológicas.
A decision-making method for consensus building applied to increase the chances of decision implementation in NPOs: the case of fundraising problem
Authors: Ziotti Vanessa , Leoneti Alexandre 
Published: August 2021

Goal: The present research aimed to demonstrate the use of a decision-making method based on game theory to support the resolution of a usual NPO’s management problem, which is the one of fundraising with different stakeholders’ preferences.
Design / Methodology / Approach: The application of the method occurred within a NPO in the city of Ribeirão Preto, Brazil, and included: (i) a phase for structuring the problem in the form of a decision matrix; and (ii) a group decision phase for supporting the NPO’s director board in their group decision-making process.
Results: The method predicted reasonably well the group decision, whose effects were demonstrated with a greater sense of justice. Two years after the decision made, the authors verified through a new visit to the NPO that the mix of the choice of the group and the method was indeed implemented.
Limitations of the investigation: It should be noted that, given the sample size, the results achieved in this study should be corroborated by other studies that eventually replicate the procedures proposed here for verification of the main hypothesis
Practical implications: However, it has been concluded that the use of a formal approach can contribute to the solution of the fundraising problem in NPOs environment, increasing the chances for decision’s implementation.
Originality / Value: It is expected that the framework proposed can be used for other problems of group decision making in NPOs by the replication of the procedures presented in the paper.
Lidocaine has antitumor effect on hepatocellular carcinoma via the circ_DYNC1H1/miR-520a-3p/USP14 axis
Authors: Liu Hua , Cheng Jing , Xu Heng , Wan Zhenzhen 
Published: August 2021

Abstract
Lidocaine can inhibit the malignant development of various human cancers. Circular RNA (circRNA) dynein 1 heavy chain gene (circ_DYNC1H1) acted as a pro-cancer molecule in hepatocellular carcinoma (HCC). This study aimed to explore whether the function of lidocaine was related to the oncogenic circ_DYNC1H1 in HCC. Colony formation assay and 3-(4,5-dimethylthiazol-2-y1)-2, 5-diphenyl tetrazolium bromide (MTT) assay were used for proliferation detection. Cell apoptosis was assessed by flow cytometry, and migration or invasion was determined by the transwell assay. The levels of circ_DYNC1H1, microRNA-520a-3p (miR-520a-3p), and ubiquitin-specific protease 14 (USP14) were examined using the quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). Protein levels were measured using western blot. The binding between miR-520a-3p and circ_DYNC1H1 or USP14 was confirmed by the dual-luciferase reporter assay. In vivo assay was conducted by a xenograft model in mice. Lidocaine reduced proliferation, migration, and invasion but promoted apoptosis in HCC cells. The circ_DYNC1H1 expression was downregulated in lidocaine-treated HCC cells. The inhibitory effect of lidocaine on HCC progression was weakened after circ_DYNC1H1 overexpression. miR-520a-3p was a target of circ_DYNC1H1, and the function of lidocaine was related to the regulation of circ_DYNC1H1/miR-520a-3p axis. USP14 served as a target for miR-520a-3p, and circ_DYNC1H1 could sponge miR-520a-3p to regulate the USP14 expression. The lidocaine-induced suppression of HCC development was also achieved by mediating the miR-520a-3p/USP14 axis. In vivo assay revealed that lidocaine suppressed the tumor growth of HCC by reducing the expression of circ_DYNC1H1 to affect the levels of miR-520a-3p and USP14. Our results clarified that lidocaine impeded tumor progression via targeting the circ_DYNC1H1/miR-520a-3p/USP14 axis in HCC cells.
Primary localized cutaneous nodular amyloidosis presenting as lymphatic malformation: A case report
Authors: Wu Xiujuan , Zhao Zongfeng 
Published: August 2021

Abstract
Primary skin amyloidosis is a chronic skin disease in which amyloid deposits in the normal skin tissues without involving other organs. At present, the causes and mechanisms of morbidity have not been fully elucidated. There are few clinical reports of nodular skin amyloidosis, and the domestic reports are mostly limited cases. This study reported a rare case of a 46-year-old woman with primary localized cutaneous nodular amyloidosis (PLCNA). The patient presented with features of lymphatic malformation, a plexiform nodule of small blisters. Histological examination revealed amyloid deposits involving the superficial and deep dermis with a small number of plasma cells. Further examinations did not reveal evidence of systemic involvement, indicating a PLCNA. The presentation as lymphatic malformation lesions illustrates the importance of clinical pathology. Nodular amyloidosis typically manifests as single or multiple yellow-brown nodules or plaques of a few millimeters to several centimeters. The center of the nodule sometimes shows atrophy and relaxation or forms a bullous. It is recommended to perform a pathological examination to confirm the diagnosis to distinguish it from lymphatic malformation.
Twig biomass allocation of Betula platyphylla in different habitats in Wudalianchi Volcano, northeast China
Authors: Yang Fan , Xie Lihong , Huang Qingyang , Cao Hongjie , Wang Jifeng , Wang Jianbo , Liu Yingnan , Ni Hongwei , Mu Liqiang 
Published: August 2021

Abstract
Understanding the response of biomass allocation in current-year twigs is crucial for elucidating the plant life-history strategies under heterogeneous volcanic habitats. We aimed to test whether twig biomass allocation, within-leaf biomass allocation, and the size-number trade-off of Betula platyphylla would be influenced. We measured twig traits of B. platyphylla in Wudalianchi volcanic kipuka, the lava platform, and Shankou lake in northeastern China using standardized major axis analyses. The results showed that the leaf number, total lamina mass (TLAM), stem mass (SM), and twig mass (TM) were significantly different between the three habitats and were greatest in kipuka with abundant soil nutrients. TLAM and SM scaled allometrically with respect to TM, while the normalization constants of the lava platform differ significantly between kipuka and Shankou lake, which showed that under certain TM, leaves gain more biomass in the lava platform. However, within the leaf, individual lamina mass (ILM) scaled isometrically with respect to individual petiole mass (IPM) in kipuka and the lava platform, but ILM scaled allometrically to IPM in Shankou lake. Our results indicated that inhabitats influenced the twig traits and biomass allocation and within-leaf biomass allocation are strategies for plants to adapt to volcanic heterogeneous habitats.
Verification of the performance of the BD MAX Check-Points CPO Assay on clinical isolates
Authors: Chung Hae-Sun , Lee Miae 
Published: August 2021

Abstract

Objectives
The BD MAX Check-Points CPO Assay (BD MAX CPO Assay; BD, The Netherlands) is a diagnostic test designed for the rapid detection and differentiation of the bla
KPC, bla
NDM, bla
VIM/bla
IMP-1, and bla
OXA-48 genes. We verified the performance of the BD MAX CPO Assay to implement it in the clinical laboratory.

Methods
A total of 113 bacterial isolates collected from various clinical specimens harboring carbapenemase genes as confirmed by polymerase chain reaction (PCR) and sequencing were evaluated. The results of the BD MAX CPO Assay were compared to previously confirmed results.

Results
All results of the BD MAX CPO Assay were concordant with previous results; 61 Klebsiella pneumoniae carbapenemase (KPC), 40 New Delhi metallo-β-lactamase (NDM), three oxacillinase-48 (OXA-48)-like, two imipenem (IMP), and four multiple carbapenemase genes (one KPC/NDM, three NDM/OXA) were detected by the BD MAX CPO Assay. Three non-carbapenemase-producing carbapenem-resistant Enterobacteriaceae isolates were negative.

Conclusions
The BD MAX CPO Assay can be used to identify carbapenemase gene in bacterial isolates cultured from clinical specimens in the clinical laboratory.
Indirect estimation of reference intervals using first or last results and results from patients without repeated measurements
Authors: Arzideh Farhad , Özcürümez Mustafa , Albers Eike , Haeckel Rainer , Streichert Thomas 
Published: August 2021

Abstract

Objectives
Indirect methods for the estimation of Reference Limits (RLs) use large data pools stored in modern laboratory information’s systems. To avoid correlation between observations repeated results from each patient should be excluded. Some data pools obtained are anonymized, and thereafter the data cannot be re-identified. The effect of the procedure of data selection on the estimations is not investigated yet.

Methods
We considered four parameters. Data sets were enclosed from two sources: a university hospital and a laboratory primarily reflecting a patient population from medical practitioners. Four algorithms were used for data selection, which generate first, last, all and non-repeated values. RLs were estimated through these data sets and compared.

Results
This study showed the broader reference range estimated by indirect methods if using the whole data set compared to first/last values or non-repeated values.

Conclusions
The use of all data without a filtering step results in a significant bias whereas the choice of first or last values has nearly no impact. The exclusion of repeated measurements results in narrower RLs. This influence confine the use of anonymous data sets where filtering is impossible for the estimation of RLs by indirect methods.
Serum Sodium Concentration and Mental Status in Children With Diabetic Ketoacidosis
Authors: Glaser Nicole S. , Stoner Michael J. , Garro Aris , Baird Scott , Myers Sage R. , Rewers Arleta , Brown Kathleen M. , Trainor Jennifer L. , Quayle Kimberly S. , McManemy Julie K. , DePiero Andrew D. , Nigrovic Lise E. , Tzimenatos Leah , Schunk Jeff E. , Olsen Cody S. , Casper T. Charles , Ghetti Simona , Kuppermann Nathan 
Published: August 2021

OBJECTIVES
Diabetic ketoacidosis (DKA) is typically characterized by low or low-normal serum sodium concentrations, which rise as hyperglycemia resolves. In retrospective studies, researchers found associations between declines in sodium concentrations during DKA and cerebral injury. We prospectively investigated determinants of sodium concentration changes and associations with mental status alterations during DKA.

METHODS
Using data from the Pediatric Emergency Care Applied Research Network Fluid Therapies Under Investigation in Diabetic Ketoacidosis Trial, we compared children who had declines in glucose-corrected sodium concentrations with those who had rising or stable concentrations. Children were randomly assigned to 1 of 4 intravenous fluid protocols that differed in infusion rate and sodium content. Data from the first 4, 8, and 12 hours of treatment were analyzed for 1251, 1086, and 877 episodes, respectively.

RESULTS
In multivariable analyses, declines in glucose-corrected sodium concentrations were associated with higher sodium and chloride concentrations at presentation and with previously diagnosed diabetes. Treatment with 0.45% (vs 0.9%) sodium chloride fluids was also associated with declines in sodium concentration; however, higher rates of fluid infusion were associated with declines in sodium concentration only at 12 hours. Frequencies of abnormal Glasgow Coma Scale scores and clinical diagnoses of cerebral injury were similar in patients with and without declines in glucose-corrected sodium concentrations.

CONCLUSIONS
Changes in glucose-corrected sodium concentrations during DKA treatment are influenced by the balance of free-water loss versus sodium loss at presentation and the sodium content of intravenous fluids. Declines in glucose-corrected sodium concentrations are not associated with mental status changes during treatment.
LOS MÉDICOS DE LA CAMPAÑA NACIONAL DE 1856-1857
Authors: Hilje Quirós Luko 
Published: August 2021

Recibido: 29-03-2021.
Aprobado: 01-05-2021.
En la Campaña Nacional de 1856-1857 contra el ejército filibustero comandado por William Walker, la salud de las tropas costarricenses estuvo a cargo de unos doce médicos, en diferentes momentos. Encabezados por el alemán Karl Hoffmann durante la primera etapa de la Campaña, los hubo tanto nacionales (Cruz Alvarado Velazco, Andrés Sáenz Llorente, Bernabé Bermúdez, Manuel María Esquivel y Bruno Carranza) como extranjeros (Santiago Hogan, Fermín Meza Orellana, Francisco Bastos, Franz Ellendorf, Alexander von Frantzius y Marquis L. Hine). Este artículo brinda una visión sintética, unificada y actualizada de la manera en que el gobierno costarricense respondió a la crisis sanitaria, así como de los aportes particulares de cada uno de los médicos y sus ayudantes de enfermería en la atención de los combatientes heridos y frente a la epidemia del cólera.
A new and previously misidentified species of Trisetella (Pleurothallidinae: Orchidaceae) from southeast Ecuador
Authors: Baquero Luis E. , Mogrovejo Adriana L. 
Published: August 2021

Trisetella pachycaudata, a new species in the subtribe Pleurothallidinae, was discovered in the Zamora Chinchipe province of southeast Ecuador, and it is described here. Trisetella pachycaudata is compared with the most similar species (and others with which it has been confused in cultivation), T. triglochin, T. strumosa, and T. vittata. It differs from them in the flowers with a much thicker apex of the sepaline tails (the thickest in the genus), and the petals expanded at the labellar margin, with the cuspidate apices erose on the upper margin and entire at the lower margin.
Key words / Palabras clave: Trisetella strumosa, Trisetella triglochin, Trisetella vittata, Zamora Chinchipe
Predicting students’ academic performance using a modified kNN algorithm
Authors: Jawthari Moohanad , Stoffová Veronika 
Published: August 2021

Abstract
The target (dependent) variable is often influenced not only by ratio scale variables, but also by qualitative (nominal scale) variables in classification analysis. Majority of machine learning techniques accept only numerical inputs. Hence, it is necessary to encode these categorical variables into numerical values using encoding techniques. If the variable does not have relation or order between its values, assigning numbers will mislead the machine learning techniques. This paper presents a modified k-nearest-neighbors algorithm that calculates the distances values of categorical (nominal) variables without encoding them. A student’s academic performance dataset is used for testing the enhanced algorithm. It shows that the proposed algorithm outperforms standard one that needs nominal variables encoding to calculate the distance between the nominal variables. The results show the proposed algorithm preforms 14% better than standard one in accuracy, and it is not sensitive to outliers.
Study of anatomical variations of pterion in Karnataka population
Authors: Sucharitha A  , Rao Chairtha , Ashwini N S  , Beez Rameeza 
Published: August 2021

The Pterion is a point of sutural confluence formed by frontal, parietal, temporal and sphenoid bones. Center of pterion is located 4cms above the midpoint of zygomatic arch and 3.5cms behind the fronto-zygomatic suture. Pterion is a reference landmark for many regions of the brain. Knowledge of various types of pterion is important in neurosurgeries as pterion keyhole approach has several advantages over traditional craniotomy; it has got radiological significance in interpretation of radiographs; in forensic medicine, it has been used for estimation of age and stature; and types of pterion has racial variations, hence it has got anthropological significance. Hence, the present study was taken to assess various types of pterion in South Indian adult human skulls. To classify the types of pterion based on Murphy’s classification and compare the right and left sides.The study was conducted on 100 adult dry human skulls collected from Kempegowda Institute of Medical Sciences & Research center, Bangalore. The various types of pterion were noted. All the readings were tabulated and subjected to analysis. All measurements and frequencies of the data were tabulated. The mean, standard deviation for each of the measurements were assessed. Statistical software SPSS version 16 was used. Right and left side were compared using One-Way ANOVA (Analysis of Variance). Various types of pterion were observed. Spheno-parietal was the most predominant (78%) type, followed by epipteric (16%), stellate (4%) and fronto-temporal (2%).: The results of the present study can be utilized by neurosurgeons, radiologists, anthropologists and forensic experts. The findings can be used in future for comparing various types of pterion from a different population, race or species altogether.
Comparison of Knowledge and Attitude among Nurses in Special Wards and Emergency of the Hospital about COVID-19: A Cross-Sectional Study in the North of Iran
Authors: Araghian Mojarad Fereshteh , Salehinia Hamid , Heydari Gorji Mohammad Ali , Hosseinnattaj Abolfazl , Talebian Fatemeh , Yaghoubi Tahereh , Jouybari Leila 
Published: August 2021

Introduction: There is a lack of studies on the knowledge and attitudes of health care workers towards COVID-19. The aim of this study was to compare the knowledge and attitudes of nurses in emergency departments and special wards of medical training centers in Mazandaran province about COVID-19 in 2020.
Material and Methods: The present study is a descriptive cross-sectional study. Which was performed in the emergency and special wards of adult educational and medical centers of Mazandaran province in 2020. Sampling is census that is easily accessible and non-random. Data collection tools included demographic information form and a researcher-made questionnaire related to knowledge and attitude. Data were analyzed by analytical tests using SPSS version 16.
Results: The findings of this study showed that the level of nurses 'knowledge was 7.78 ±0.85 and the level of nurses' attitude was 6.87± 0.90. There was no statistically significant difference between knowledge and attitude in emergency and special ward’s nurses. There is no significant relationship between education level, age and work experience with knowledge and attitude.
Conclusion: According to the findings, the level of knowledge of nurses was insufficient and the level of attitude of nurses was sufficient. Therefore, it is recommended nursing managers should plan to increase the level of awareness of nursing staff. Prepare virtual educational content in the field of treatment, nursing care and complications of COVID-19.
​Demonstration of Ecological Engineering based Pest Management in Rice Oryza sativa L. through Farmers Participatory Approach
Authors: Shanmugam P.S. , Sangeetha M. , Ayyadurai P. , Prasad Y.G. 
Published: August 2021

Background: Rice is one of the predominant cereal crop grown in Dharmapuri district of Tamil Nadu state, India in approximately 4000 hectares with a average productivity of 4500 kg/ha. Hoppers, stem borer, leaf folder, gall midge and ear head bugs are the major insect pests for which farmers resort management practices. Instead of curative management, farmers mostly use the insecticide as prophylactic management which leads to unwarranted problems. Though integrated pest management has been advocated as an alternate strategy, farmers are reluctant to use all the components of IPM and rely on mostly on insecticides. In this context, the ecological engineering pest management can form a better alternative, which also coincides with the age old practice of growing border crops in this region. Methods: The potential of Ecological Engineering Pest Management (EEPM) was assessed in comparison with Integrated Pest Management (IPM) and Farmers Practice (FP) in five farmer’s fields. Based on the results, ten and twenty front line demonstrations were conducted during consecutive years to study the performance of EEPM in Dharmapuri district. Result: The number of hopper/hill, per cent dead heart, per cent white ears in the EEPM was 10.65, 7.07 and 9.65 and in the IPM module 10.18, 8.40 and 11.55 and in the farmers practice 6.73, 10.73 and 12.75 respectively. The natural enemies viz., coccinellids/hill and spiders/hill were more in EEPM (2.00 and 3.15) and least in the farmers practice (0.40 and 0.86). The number of hoppers/hill, per cent dead heart, number of coccinellids/hill and number of spiders per hill was 8.40, 6.00, 3.00 and 1.40 in EEPM and 6.20, 5.40, 1.20 and 0.60 in farmers practice respectively in the 2016-17 front line demonstrations. The EEPM module recorded 8.1, 8.65, 3.5 and 1.75 hopper/hill, per cent dead heart, coccinellids/hill and spiders/hill in 2017-18 front line demonstrations. The farmers were able to save Rs. 5000/- from the plant protection cost apart from getting additional revenue in EEPM. The combination of border crops, influence of border crop on rodent damage in rice ecosystem and benefits of providing separate niche area than border crop are the researchable areas. In spite of above constraints the EEPM can be followed in rice ecosystem with the locally available crop combination to reduce the insecticide usage and increase the beneficials.