bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social class and wellbeing among staff and students in higher education settings: Mapping the problem and exploring underlying mechanisms
Authors: Dougall Isla , Weick Mario , Vasiljevic Milica 
Published: August 2021

AbstractWithin Higher Education (HE), staff and students from lower social class backgrounds often experience poorer wellbeing than their higher social class counterparts. Previous research conducted outside educational contexts has linked social class differences in wellbeing with differences in the extent to which low and high social class individuals feel respected (i.e., status), in control (i.e., autonomy), and connected with others (i.e., inclusion). However, to our knowledge, there has been no research that has investigated these psychosocial needs within HE settings. Furthermore, inclusion, status and autonomy are correlated, yet little is known about how these psychosocial needs contribute to wellbeing simultaneously, and independently, of one another. To fill these gaps, we report the results of two studies; firstly with HE students (Study 1; N = 305), and secondly with HE staff (Study 2; N = 261). Consistently across studies, reports of poor wellbeing were relatively common and more than twice as prevalent amongst lower social class staff and students compared to higher social class staff and students. Inclusion, status and autonomy each made a unique contribution and accounted for the relationship between social class and wellbeing (fully amongst students, and partially amongst staff members). These relationships held across various operationalizations of social class and when examining a range of facets of wellbeing. Social class along with inclusion, status and autonomy explained a substantial 40% of the variance in wellbeing. The present research contributes to the literature exploring how social class intersects with psychosocial needs to impact the wellbeing of staff and students within HE.
Long non‐coding RNA TMPO‐AS1 facilitates the progression of colorectal cancer cells via sponging miR‐98‐5p to upregulate BCAT1 expression
Authors: Ye Jinjun , Yan Yukuang , Xin Le , Liu Jidong , Tang Tao , Bao Xing 
Published: August 2021

AbstractBackground and AimColorectal cancer, as a common malignant carcinoma in the gastrointestinal tract, has a high mortality globally. However, the specific molecular mechanisms of long non‐coding RNA (lncRNA) thymopoietin antisense transcript 1 (TMPO‐AS1) in colorectal cancer were unclear.MethodsWe tested the expression level of TMPO‐AS1 via qRT‐PCR in colorectal cancer cells, while the protein levels of branched chain amino acid transaminase 1 (BCAT1) and the stemness‐related proteins were evaluated by western blot analysis. Colony formation, EdU staining, TUNEL, flow cytometry, and sphere formation assays were to assess the biological behaviors of colorectal cancer cells. Then, luciferase reporter, RIP, and RNA pull down assay were applied for confirming the combination between microRNA‐98‐5p (miR‐98‐5p) and TMPO‐AS1/BCAT1.ResultsTMPO‐AS1 was aberrantly expressed at high levels in colorectal cancer cells. Silenced TMPO‐AS1 restrained cell proliferation and stemness and promoted apoptosis oppositely, while overexpressing TMPO‐AS1 exerted the adverse effects. Furthermore, miR‐98‐5p was proven to a target of TMPO‐AS1 inhibit cell progression in colorectal cancer. Additionally, BCAT1 was proved to enhance cell progression as the target of miR‐98‐5p, and it offset the effect of silenced TMPO‐AS1 on colorectal cancer cells.ConclusionTMPO‐AS1 promotes the progression of colorectal cancer cells via sponging miR‐98‐5p to upregulate BCAT1 expression.
Drainage of pancreatic fluid collections using a lumen‐apposing metal stent with an electrocautery‐enhanced delivery system
Authors: Khan Saad , Chandran Sujievvan , Chin Jerry , Karim Shwan , Mangira Dileep , Nasr Mohamad , Ermerak Goktug , Trinh Andrew , Kia Christopher Y H , Mules Thomas , Zad Mohammadali , Ang Tiing Leong , Johns Estella , Tee Derrick , Kaul Abha , Ratanachu‐Ek Thawee , Jirathan‐Opas Jirat , Fisher Leon , Cameron Rees , Welch Christine , Lim Gary , Metz Andrew J , Moss Alan , Bassan Milan , Saxena Payal , Kaffes Arthur , St John Andrew , Hourigan Luke F , Tagkalidis Peter , Weilert Frank , Vaughan Rhys , Devereaux Benedict 
Published: August 2021

AbstractBackground and AimOur aim was to evaluate the efficacy and safety of a lumen‐apposing metal stent with an electrocautery‐enhanced delivery system (EDS‐LAMS) for endoscopic ultrasound (EUS)‐guided drainage of pancreatic fluid collections (PFCs) in regular clinical practice.MethodsA retrospective and subsequent prospective analysis was undertaken of all patients who underwent EUS‐guided drainage of their PFCs using the EDS‐LAMS at 17 tertiary therapeutic endoscopy centers.ResultsTwo hundred eight cases of EDS‐LAMS deployment were attempted in 202 patients (mean age 52.9 years) at time of evaluation. Ninety‐seven patients had pancreatic pseudocysts (PPs), 75 walled‐off pancreatic necrosis (WOPN), 10 acute peripancreatic fluid collections (APFCs), 6 acute necrotic collections (ANCs), and 14 postoperative collections (POCs). Procedural technical success was achieved in 202/208 cases (97.1%). Maldeployment occurred in 7/208 cases (3.4%). Clinical success was achieved in 142/160 (88.8%) patients (PP 90%, WOPN 85.2%, APFC 100%, ANC 75%, POC 100%). Delayed adverse events included stent migration in 15/202 (7.4%), stent occlusion and infection in 16/202 (7.9%), major bleeding in 4/202 (2%), and buried EDS‐LAMS in 2/202 (1%). PFC recurrence occurred in 13/142 (9.2%) patients; 9/202 (4.5%) required surgical or radiological intervention for PFC management after EDS‐LAMS insertion.ConclusionsThis large international multicenter study evaluating the EDS‐LAMS for drainage of PFCs in routine clinical practice suggests that the EDS‐LAMS are safe and effective for drainage of all types of PFCs; however, further endoscopic therapy is often required for WOPN. Major bleeding was a rare complication in our cohort.
A framework to analyze the dynamics of the socioeconomic metabolism of countries: A Portuguese case study
Authors: Cunha Sónia , Ferrão Paulo 
Published: August 2021

AbstractSocioeconomic metabolism dynamics are relevant to identify (un)sustainable development pathways in different economies, particularly if the evolution of resource productivity of critical economic sectors can be quantified. This paper offers a four‐step methodological framework to quantify these dynamics for an economy in a way that can be replicated for a series of years and countries. This methodological framework is based on the compilation of economic and physical flows in the form of input‐output tables in a time series, making use of publicly available data. The data download and processing were automatized using Python, creating an expedited analysis process. The results characterize the flows through and within a country and allow the user to identify structural changes in the economy by tracking both monetary and physical flows for 17 material groups and up to 37 economic sectors. The application of the methodological framework is illustrated in a case study covering the 2008 economic crisis in Portugal, in which the socioeconomic metabolism, the underlying structural changes, and the corresponding environmental impacts are characterized. The use of this information for the design of decoupling policies is discussed, in view of promoting sustainable dematerialization during periods of economic prosperity.
A survey study of the attitudes and experiences of adults with intellectual disability regarding participation in research
Authors: Conroy N. E. , McDonald K. E. , Olick R. S. ,   The Project ETHICS Expert Panel Members
Published: August 2021

AbstractBackgroundHistorically, people with intellectual disability have been exploited in and excluded from scientific research. To facilitate greater representation of adults with intellectual disability as research respondents, we sought to understand their interest in research participation and factors affecting their willingness to volunteer to participate, such as the core value of trust.MethodsOur survey measured attitudes of adults with intellectual disability towards research in general and research specifically involving adults with intellectual disability as respondents, as well as their prior research experiences, trust of researchers and interest in future research participation.ResultsParticipants reported positive attitudes towards research and strong interest in future participation opportunities, and trust of researchers was positively correlated to both. The belief that ‘research about adults with intellectual disability is very important’ also predicted participants' interest in future research participation.ConclusionsOur findings indicate that adults with intellectual disability support the direct involvement of adults with intellectual disability in research as respondents. Trustworthy rapport with researchers and positive views about research foster greater inclusion of this population.
Thioredoxin interacting protein drives astrocytic glucose hypometabolism in corticosterone‐induced depressive state
Authors: Pan Shu‐Man , Pan Ying , Tang Ya‐Li , Zuo Na , Zhang Yan‐Xiu , Jia Ke‐Ke , Kong Ling‐Dong 
Published: August 2021

AbstractBrain energetics disturbance is a hypothesized cause of depression. Glucose is the predominant fuel of brain energy metabolism; however, the cell‐specific change of glucose metabolism and underlying molecular mechanism in depression remains unclear. In this study, we firstly applied 18F‐FDG PET and observed brain glucose hypometabolism in the prefrontal cortex (PFC) of corticosterone‐induced depression of rats. Next, astrocytic glucose hypometabolism was identified in PFC slices in both corticosterone‐induced depression of rats and cultured primary astrocytes from newborn rat PFC after stress‐level corticosterone (100 nM) stimulation. Furthermore, we found the blockage of glucose uptake and the decrease of plasma membrane (PM) translocation of glucose transporter 1 (GLUT1) in astrocytic glucose hypometabolism under depressive condition. Interestingly, thioredoxin interacting protein (TXNIP), a glucose metabolism sensor and controller, was found to be over‐expressed in corticosterone‐stimulated astrocytes in vivo and in vitro. High TXNIP level could restrict GLUT1‐mediated glucose uptake in primary astrocytes in vitro. Adeno‐associated virus vector‐mediated astrocytic TXNIP over‐expression in rat medial PFC suppressed GLUT1 PM translocation, consequently developed depressive‐like behavior. Conversely, TXNIP siRNA facilitated GLUT1 PM translocation to recover glucose hypometabolism in corticosterone‐exposed cultured astrocytes. Notably, astrocyte‐specific knockdown of TXNIP in medial PFC of rats facilitated astrocytic GLUT1 PM translocation, showing obvious antidepressant activity. These findings provide a new astrocytic energetic perspective in the pathogenesis of depression and, more importantly, provide TXNIP as a promising molecular target for novel depression therapy.
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Experiences and perceptions of stroke patients living with dysphagia: A qualitative meta‐synthesis
Authors: Li Chen , Qiu Chunmei , Shi Ying , Yang Tao , Shao Xinmei , Zheng Dongxiang 
Published: August 2021

AbstractAimsTo systematically review and synthesise the findings of qualitative research exploring experiences of dysphagia from stroke patients' perspectives.BackgroundPoststroke patients with dysphagia are suffering from impaired physical functions and heavy psychological burden, and they are living with compromised quality of life. Through synthesising qualitative studies to fully portrait the experiences of poststroke patients living with dysphagia, we can care better for this population.DesignA systematic review and synthesis of qualitative studies reported by following ENTREQ.Review MethodsFive electronic databases (CINAHL, Embase, PubMed, Web of Science and Cochrane Library) and three Chinese databases (CNKI, VIP and Wanfang) were searched from inception until January 2021. Qualitative studies were included if they were related to the experiences of poststroke patients with dysphagia. The Joanna Briggs Institute Qualitative Assessment and Review Instrument (JBI‐QARI) was used to appraise study quality. Data were synthesised using the Thomas and Harden method thematic and content analysis.ResultsFive studies were included in the meta‐synthesis. Four analytical themes were identified: life changes after dysphagia, coping with social events, rebuilding a normal life and limited professional services.ConclusionsMore attention should be given to psychological health and social interaction in poststroke dysphagia patients. Healthcare professionals, especially nurses, should make joint efforts to provide patients with dysphagia‐related knowledge and long‐term individualised support. To improve the quality of life of dysphagia patients, further research should implement high‐quality interventions based on dysphagia experience and clinical treatment.Relevance to clinical practiceThese findings outline the changes in poststroke patients with dysphagia. Nurses as the first‐line force, should deliver comprehensive and individualised intervention for managing physiological and psychosocial symptoms of patients.
Valuing Private Equity Investments Strip by Strip
Authors: GUPTA ARPIT , VAN NIEUWERBURGH STIJN 
Published: August 2021

ABSTRACTWe propose a new valuation method for private equity (PE) investments. It constructs a replicating portfolio using cash flows on listed equity and fixed‐income instruments (strips). It then values the strips using an asset pricing model that captures the risk in the cross‐section of bonds and equity factors. The method delivers a risk‐adjusted profit on each PE investment and a time series for the expected return on each fund category. We find negative risk‐adjusted profits for the average PE fund, with substantial heterogeneity and some persistence in the performance. Expected returns and risk‐adjusted profit decline in the later part of the sample.
International trade and Covid‐19: City‐level evidence from China's lockdown policy
Authors: Pei Jiansuo , de Vries Gaaitzen , Zhang Meng 
Published: August 2021

AbstractThis paper examines the impact of Covid‐19 lockdowns on exports by Chinese cities. We use city‐level export data at a monthly frequency from January 2018 through April 2020. Differences‐in‐differences estimates suggest cities in lockdown experienced a ceteris paribus 34 percentage points reduction in the year‐on‐year growth rate of exports. The lockdown impacted the intensive and extensive margin, with higher exit and lower new entry into foreign markets. The drop in exports was smaller in (i) coastal cities; (ii) cities with better‐developed ICT infrastructure; and (iii) cities with a larger share of potential teleworkers. Time‐sensitive and differentiated goods experienced a more pronounced decline in export growth. Global supply chain characteristics matter, with more upstream products and industries that had accumulated larger inventories experiencing a smaller decline in export growth. Also, products that relied more on imported (domestic) intermediates experienced a sharper (flatter) slowdown in export growth. The rapid recovery in cities' exports after lockdowns were lifted suggests the policy was cost‐effective in terms of its effects on trade.
Clinical characterization of NTCP deficiency in paediatric patients : A case‐control study based on SLC10A1 genotyping analysis
Authors: Deng Li‐Jing , Ouyang Wen‐Xian , Liu Rui , Deng Mei , Qiu Jian‐Wu , Yaqub Muhammad‐Rauf , Raza Muhammad‐Atif , Lin Wei‐Xia , Guo Li , Li Hua , Chen Feng‐Ping , Ouyang Ying , Huang Yu‐Ge , Huang Yue‐Jun , Long Xiao‐Ling , Huang Xiao‐Ling , Li Shuang‐Jie , Song Yuan‐Zong 
Published: August 2021

AbstractNa+‐taurocholate cotransporting polypeptide deficiency (NTCPD) is a newly described disorder arising from biallelic mutations of the SLC10A1 gene. As a result of a lack of compelling evidence from case‐control studies, its genotypic and phenotypic features remain open for in‐depth investigation. This study aimed to explore the genotypic and clinical phenotypic characteristics of paediatric patients with NTCPD. The SLC10A1 genotypes of all NTCPD patients were confirmed by screening for the prevalent variant c.800C>T and Sanger sequencing when necessary. The clinical presentations and laboratory changes were collected, reviewed and analysed, and then qualitatively and quantitatively compared with the relevant controls. A total of 113 paediatric NTCPD patients were diagnosed while c.374dupG and c.682_683delCT were detected as two novel pathogenic mutations. Hypercholanemia was observed in 99.12% of the patients. Indirect hyperbilirubinemia in affected neonates exhibited higher positive rates in comparison to controls. Moreover, transient cholestatic jaundice, elevated liver enzymes and 25‐hydroxyvitamin D (Vit D) deficiency during early infancy were more commonly observed in patients than in controls. All NTCPD patients exhibited favourable clinical outcomes as a result of symptomatic and supportive treatment. The findings enriched the SLC10A1 mutation spectrum and provided comprehensive insights into the phenotypic characteristics of NTCPD. NTCPD should be considered and SLC10A1 gene should be analysed in patients with above age‐dependent clinical features. Furthermore, over investigation and intervention should be avoided in the management of NTCPD patients.
ILK regulates osteogenic differentiation of Human Periodontal Ligament Stem Cells through YAP‐mediated Mechanical Memory
Authors: He Chuan , Wang Tairan , Wang Yijie , Xu Tongtong , Zhao Shuyang , Shi Haoyu , Zou Rui 
Published: August 2021

AbstractMechanical memory meant the mechanical properties of the matrix could influence the cell fate even after the matrix was changed and has been justified in many kinds of cells. To utilize the phenomenon to improve periodontal tissue engineering, we studied whether mechanical memory existed in human periodontal ligament stem cells and testified if ILK plays a role in this process. The substrate of different stiffness was fabricated by gelatin methacrylate hydrogel. Two groups of hPDLSCs with stiff (St) and soft (So) matrix, respectively, were cultivated. Then, half of the cells exchanged their matrix stiffness in the fourth passage and therefore So, St, So‐St, and St‐So were formed. Morphology of hPDLSCs and intracellular location of YAP was observed via fluorescence staining, osteogenic differentiation of hPDLSCs was assessed by real‐time PCR, ALP staining, and Western blot. Then, all these were reassessed after the ILK gene had been knocked down. The results showed that morphology and YAP location of hPDLSCs were different between matrix changed and unchanged groups; osteogenic genes expression, ALP staining, and Western blot also varied. After the ILK gene had been knocked down, the YAP location and osteogenic activity of hPDLSCs were significantly influenced. Thus, it could be concluded that mechanical memory exists in hPDLSCs; ILK is involved in this process.
The kinetic profile of clinical and laboratory findings and treatment outcome of patients with toxocariasis
Authors: Phuc Le Dinh Vinh , Hai Tang Xuan , Loi Cao Ba , Quang Huynh Hong , Vinh Le Duc , Le Tran‐Anh 
Published: August 2021

AbstractObjectivesHuman toxocariasis is a widespread zoonosis for which a chemotherapy decision and therapy effectiveness are difficult to determine. We aimed to investigate the kinetic profile of clinical and laboratory findings and treatment outcome of patients with toxocariasis in Vietnam.MethodsThe prospective study was conducted between October 2017 and June 2019. The diagnosis of toxocariasis was established based on clinical, laboratory (eosinophilia, raised IgE concentration) and serological (positive Toxocara IgG ELISA) evaluation as well as the exclusion of another helminthic co‐infection. The patients were followed up after seven days, then one, three and six months after chemotherapy by thiabendazole.ResultsThe study involved 80 patients with a mean age of 41.6 ± 15.2 years of whom 58.8% were female. At three and six months after chemotherapy, most patients demonstrated resolution of clinical signs and symptoms, eosinophil count and IgE concentration but not in the proportion of IgG seropositivity. Skin lesions and eosinophilia resolved earlier than the other symptoms (one month after treatment). About four‐fifths of the patients were “cured” after three and six months of follow‐up; 33.8% showed side effects to thiabendazole therapy but no severe events were reported. The most common adverse reaction was neurologic symptoms followed by gastrointestinal or skin manifestations which lasted as long as 4 days.ConclusionsIn toxocariasis patients, cutaneous manifestations and eosinophilia resolve more rapidly than other clinical and laboratory findings while IgG titre has a very slow kinetic after therapy. Thiabendazole seems to be a potential alternative for the treatment of human toxocariasis.
The Phyllotis xanthopygus complex (Rodentia, Cricetidae) in central Andes, systematics and description of a new species
Authors: Jayat J. Pablo , Teta Pablo , Ojeda Agustina A. , Steppan Scott J. , Osland Jared M. , Ortiz Pablo E. , Novillo Agustina , Lanzone Cecilia , Ojeda Ricardo A. 
Published: August 2021

AbstractPhyllotis Waterhouse 1837 is one of the most studied genera of South American cricetid rodents. As currently understood, it includes 20 small to medium‐sized species of predominantly rocky habitats. Among them, populations of the yellow‐rumped leaf‐eared mouse, traditionally referred to P. xanthopygus (Waterhouse 1837), are the most widely distributed, extending from central Peru to southern Chile and Argentina. Based mostly on molecular evidence, previous studies suggested that P. xanthopygus constitutes a species complex, being characterized by geographically structured and genetically divergent clades. In this work, we compare the molecular phylogenetic hypothesis for populations distributed on the eastern slopes of the central Andes with morphometric evidence using univariate and multivariate analyses. Quantitative morphological and molecular evidence suggests that at least four nearly cryptic species of the P. xanthopygus complex occur from southern Bolivia to west‐central Argentina. Three of these taxa have available names; one of them, P. caprinus, is currently recognized to the species level; the other two, the clades of P. x. posticalis‐P. x. rupestris and P. vaccarum, are both recognized as subspecies of P. xanthopygus. The remaining taxon represents a new species distributed in the west‐central Andes of Argentina. We discuss our morphological results in the light of other sources of evidence (e.g. qualitative and quantitative state characters, genetic and phylogenetic studies, and cytogenetic data) and name the new species as P. pehuenche, honouring the original native people that historically inhabited west‐central Andes of Argentina.