bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemoresponse of de novo Acute Myeloid Leukemia to “7+3” Induction can Be Predicted by c-Myc-facilitated Cytogenetics
Authors: Hsiao Tzu-Hung , Wang Ren Ching , Lu Tsai-Jung , Shih Chien-Hung , Su Yu-Chen , Tsai Jia-Rong , Jhan Pei-Pei , Lia Cai-Sian , Chuang Han-Ni , Chang Kuang-Hsi , Teng Chieh-Lin 
Published: April 2021

Background: Identifying patients with de novo acute myeloid leukemia (AML) who will probably respond to the “7 + 3” induction regimen remains an unsolved clinical challenge. This study aimed to identify whether c-Myc could facilitate cytogenetics to predict a “7 + 3” induction chemoresponse in de novo AML.Methods: We stratified 75 untreated patients (24 and 51 from prospective and retrospective cohorts, respectively) with de novo AML who completed “7 + 3” induction into groups with and without complete remission (CR). We then compared Myc-associated molecular signatures between the groups in the prospective cohort after gene set enrichment analysis. The expression of c-Myc protein was assessed by immunohistochemical staining. We defined high c-Myc-immunopositivity as &gt; 40% of bone marrow myeloblasts being c-Myc (+).Results: Significantly more Myc gene expression was found in patients who did not achieve CR by “7 + 3” induction than those who did (2439.92 ± 1868.94 vs. 951.60 ± 780.68; p = 0.047). Expression of the Myc gene and c-Myc protein were positively correlated (r = 0.495; p = 0.014). Although the non-CR group did not express more c-Myc protein than the CR group (37.81 ± 25.13% vs. 29.04 ± 19.75%; p = 0.151), c-Myc-immunopositivity could be a surrogate to predict the “7 + 3” induction chemoresponse (specificity: 81.63%). More importantly, c-Myc-immunopositivity facilitated cytogenetics to predict a “7 + 3” induction chemoresponse by increasing specificity from 91.30 to 95.92%.Conclusion: The “7 + 3” induction remains the standard of care for de novo AML patients, especially for those without a high c-Myc-immunopositivity and high-risk cytogenetics. However, different regimens might be considered for patients with high c-Myc-immunopositivity or high-risk cytogenetics.
Volatile Liquid Detection by Terahertz Technologies
Authors: Baxter Harry W , Worrall Adam A , Pang Jie , Chen Riqing , Yang Bin 
Published: April 2021

The prospect of being able to move through security without the inconvenience of separating liquids from bags is an exciting one for passengers, and there are important operational benefits for airports as well. Here, two terahertz (THz) systems, 100 GHz sub-THz line scanner and attenuation total reflection-based THz time domain spectroscopy (TDS), have been used to demonstrate the capability of identifying different liquid samples. Liquid samples’ THz complex permittivities are measured and their differences have contributed to the variation of 100 GHz 2D images of volatile liquids with different volumes inside of cannister bottles. The acquired attenuation images at 100 GHz can easily be used to distinguish highly absorbed liquids (Water, Ethanol, Fuel Treatment Chemicals) and low loss liquids (Petrol, Diesel, Kerosene and Universal Bottle Cleaner). The results give a promising feasibility for mm-wave imager and THz spectroscopy to efficiently identify different volatile liquids.
Evidence for an Interaction Between NEDD4 and Childhood Trauma on Clinical Characters of Schizophrenia With Family History of Psychosis
Authors: Bi Xiao-Jiao , Hu Lei , Qiao Dong-Dong , Han Chao , Sun Meng-Meng , Cui Kai-Yan , Wang Li-Na , Yang Li-Min , Liu Lan-Fen , Chen Zhe-Yu 
Published: April 2021

Background: Neural precursor cell-expressed developmentally downregulated 4 (NEDD4) polymorphisms and childhood trauma (CT) are associated with schizophrenia. However, whether NEDD4 interacts with CT on symptoms of schizophrenia remains unknown. This study aimed to investigate the gene–environment interaction effect.Methods: We recruited 289 schizophrenia patients and 487 controls and genotyped rs2303579, rs3088077, rs7162435, rs11550869, and rs62043855 in their NEDD4 gene.Results: We found significant differences in the rs2303579 and rs3088077 between the two groups. Patients with the rs2303579 CC genotype had higher scores compared with other genotype (P = 0.026) in the test of positive schizophrenia syndrome scores, whereas patients with the rs3088077 TT (P = 0.037) and rs7162435 CC genotypes (P = 0.009) had higher scores compared with the other genotypes in the test of excitement factor. Patients with a family history of psychosis (FH+) reported higher negative scores (P = 0.012) than those without. Patients exposed to physical abuse (PA) reported a lower language learning and memory score (P = 0.017) and working memory score (P = 0.047) than those not. Patients exposed to sexual abuse (SA) reported a lower reasoning and problem-solving skills score (P = 0.025); those exposed to emotional neglect (EN) reported a lower social cognition score (P = 0.044); and those exposed to physical neglect reported a lower social cognition score (P = 0.036) but higher visual learning and memory score (P = 0.032). Rs3088077 could interact with EN to increase risk for schizophrenia. Optimal model rs62043855 × EA, rs3088077 × rs7162435 × rs11550869 × SA × EN and rs2303579 × rs7162435 × rs11550869 × rs62043855 × EA × PA could explain positive symptom, excitement symptom and working memory, respectively, in FH+ group.Conclusion: The study highlighted that the combined interaction of NEDD4 and CT may be associated with symptoms of schizophrenia especially for those with FH+.
Digital Communication Biomarkers of Mood and Diagnosis in Borderline Personality Disorder, Bipolar Disorder, and Healthy Control Populations
Authors: Gillett George , McGowan Niall M. , Palmius Niclas , Bilderbeck Amy C. , Goodwin Guy M. , Saunders Kate E. A. 
Published: April 2021

Background: Remote monitoring and digital phenotyping harbor potential to aid clinical diagnosis, predict episode course and recognize early signs of mental health crises. Digital communication metrics, such as phone call and short message service (SMS) use may represent novel biomarkers of mood and diagnosis in Bipolar Disorder (BD) and Borderline Personality Disorder (BPD).Materials and Methods: BD (n = 17), BPD (n = 17) and Healthy Control (HC, n = 21) participants used a smartphone application which monitored phone calls and SMS messaging, alongside self-reported mood. Linear mixed-effects regression models were used to assess the association between digital communications and mood symptoms, mood state, trait-impulsivity, diagnosis and the interaction effect between mood and diagnosis.Results: Transdiagnostically, self-rated manic symptoms and manic state were positively associated with total and outgoing call frequency and cumulative total, incoming and outgoing call duration. Manic symptoms were also associated with total and outgoing SMS frequency. Transdiagnostic depressive symptoms were associated with increased mean incoming call duration. For the different diagnostic groups, BD was associated with increased total call frequency and BPD with increased total and outgoing SMS frequency and length compared to HC. Depression in BD, but not BPD, was associated with decreased total and outgoing call frequency, mean total and outgoing call duration and total and outgoing SMS frequency. Finally, trait-impulsivity was positively associated with total call frequency, total and outgoing SMS frequency and cumulative total and outgoing SMS length.Conclusion: These results identify a general increase in phone call and SMS communications associated with self-reported manic symptoms and a diagnosis-moderated decrease in communications associated with depression in BD, but not BPD, participants. These findings may inform the development of clinical tools to aid diagnosis and remote symptom monitoring, as well as informing understanding of differential psychopathologies in BD and BPD.
Catering Students Perception on Working in Hospitality Jobs
Authors: Senthil Kumar S 
Published: April 2021

Hotel Management Institutions are growing year after year in south Tamilnadu. More & more students are passing out every year. In recent years many of them are showing interest to join in the hotel management course because of various opportunities available in the course as well as the fastest career growth in the industry. When the students join this course, they have a very positive attitude towards this course, year by year, this positive attitude is decreasing when they are passing out/ final year of study they want to change their industry. Hence in this study, a structured questionnaire was prepared and circulate among the students to find the reason. The data scrutinize with the help of SPSS. Further, the t-test, Anova test to find out the significant differences and concluded with some suggestions to enhance the training experience of the students.
A Study on Consumer’s Opinion towards Packaged Instant Food Products in Madurai City
Authors: Duraichamy J , Karthik T T 
Published: April 2021

In developing countries like India both men and women are working for survival; in this tight schedule, packaged instant foods make their cooking process easy and saves time. Packaged instant food products simplify the cooking process and speed ups the cooking. Nowadays, every supermarket shelf is filled with instant food products. As customers are willing to buy more, so it is important to analyze their opinion regarding packed instant food. In a study, an attempt ah been made to analyze the customer’s level of opinion towards packaged instant food. The objective of the study is to analyze the opinion of the customers towards packaged instant food products. A sample survey was conducted in Madurai city; the sample size is 45. The questionnaire has been used to collect primary data from the respondents. SPSS software is used to analyze the data statistics.
The Propaganda Model in the Digital Age: A Review of Literature on the Effects of Social Media on News Production
Authors: Demuyakor John 
Published: April 2021

The 21st century is best described by many as the Digital Age. The digital revolution at the beginning of the century has witnessed the introduction of social media platforms. About two decades now, globally, the are several questions on the effects of social media on the new production. While a section of media and communication experts view that social media has positively promoted news production, other scholars strongly see the negative side of social media in news production, especially with the context of the propaganda model. The objective of this article is to offer insightful review literature on the effects of social media on news production, within the context of the propaganda model to improve the reader’s understanding of the role of social media news production. The review is divided into two sections; the first part gives us much insight into what the propaganda model is all about, and the second section critically looks at the net effects of social media in news making via the propaganda model.
A Study on Jainism History, Philosophy and Traditions in Tamilnadu
Authors: Rajeshwari M , Amirthavalli A 
Published: April 2021

In Tamil Nadu Hinduism and Buddhism, Jainism is one of the three oldest Indian strict conventions still in presence and a necessary piece of South indian strict conviction and practice. While frequently utilizing ideas imparted to Hinduism and Buddhism, the consequence of a typical social and phonetic foundation, the Jain convention should be viewed as a free marvel as opposed to as a Hindu order or a Buddhist blasphemy, as some previous Western researchers accepted. In South India, Jainism is minimal in overflow of a name. Indeed, even genuine understudies of religion in India gave little consideration to it. In a populace of almost 60 crores of individuals, Jainas may establish almost nearly 3 million individuals. Jainism is the religion of the Jains who follow the way, lectured and rehearsed by the Jinas. It is a fully evolved and grounded religion and social framework that rose up out of 6 century BC .The trademark highlight of this religion is its case to all inclusiveness which it holds essentially contrary to Brahmanism. It very well may be said that throughout the previous 2500 years the Jains have contributed such a huge amount to each circle of life of Indian individuals both as a religion and a way of thinking. They contributed a lot to the regions of culture, language, exchange and agribusiness, or all in all the Jains opened up another period of human thoughts and musings. In Indian History, endeavors were made to contemplate Jainism as a religion and its commitments yet focus on the Jain movement into Tamil Nadu and its effects are restricted. An endeavor is made in this examination to investigate the recorded geology of the Jain focuses in Tamil Nadu.
Hubungan dukungan sosial dengan kualitas hidup lansia
Authors: Nofalia Ifa 
Published: April 2021

Penuaan merupakan fenomena global yang mempengaruhi negara maju dan berkembang. Faktor penentu kesehatan fisik dan mental pada populasi lansia tentunya berbeda. Jaringan sosial yang kuat dengan tingkat dukungan sosial yang tinggi umumnya merupakan faktor pelindung untuk menjaga kesehatan dan kualitas hidup yang baik di usia tua. Tujuan penelitian ini adalah untuk mengetahui hubungan dukungan sosial dengan kualitas hidup lansia.
Penelitian ini menggunakan desain crossectional. Populasi dalam penelitian ini adalah semua lansia yang ada di Dusun Boti Desa Turi Kecamatan Tambakrejo Kabupaten Bojonegoro sebanyak 112 orang dengan jumlah sampel sebanyak 40 responden dengan menggunakan teknik pengambilan sampel simple random sampling. Dukungan sosial merupakan variabel independen dan kualitas hidup lansia menjadi variabel dependen. Pengumpulan data menggunakan kuesioner. Pengolahan data dengan editing, koding, skoring, tabulating dan analisis menggunakan uji statistik Korelasi Spearman’s rho dengan alpha 0,05.
Hasil penelitian menunjukkan sebagian besar dukungan sosial kategori baik sebanyak 21 responden (52,5%) dan kualitas hidup lansia sebagian besar baik sebanyak 23 responden (57,5%). Hasil uji statistik Korelasi Spearman’s rho didapatkan nilai p = 0,007 lebih kecil dari alpha 0,05 sehingga H1 diterima.
Kesimpulan dalam penelitian ini adalah ada hubungan dukungan sosial dengan kualitas hidup lansia di Dusun Boti Desa Turi Kecamatan Tambakrejo Kabupaten Bojonegoro.
Persepsi keluarga dengan riwayat kanker payudara dalam upaya deteksi kanker payudara
Authors: Prasetyaningati Dwi 
Published: April 2021

Keluarga merupakan bagian penting dalam proses perawatan anggota keluraga yang menderita sakit. Pengalaman kesakitan dan berbagai terapi yang dilalui oleh penderita kanker payudara memberikan dampak pengalaman kepada keluarga secara langsung untuk mempersepsikan bagaimana harus bertindak supaya tidak terjadi hal yang sama baik pada diri sendiri atau anggota keluarga lainya. Penelitian ini dilakukan untuk mendapatkan pengalaman langsung dari anggota keluarga yang merawat penderita kanker payudara dan bagaimana persepsinya dalam upaya deteksi dini kanker payudara secara langsung.
Partisipan berjumlah empat orang dari pasien penderita kanker payudara yang dipilih dengan teknik purposive. Wawancara dijalankan secara semi-terstruktur. Transkrip wawancara kemudian dianalisis dengan pendekatan Interpretative Phenomenological Analysis (IPA). Tema superordinat yang ditemukan mencakup (1) Persepsi keluarga terhadap kanker sebagai penyakit yang mengancam kehidupan, (2) Pengalaman keluarga merawat penderita kanker, (3) Masalah yang dihadapi Keluarga saat melakukan perawatan selama sakit, (4) Upaya mempertahankan kesehatan, (5) Persepsi deteksi dini kejadian Kanker Payudara.
Empat partisipan menunjukkan pemaknaan dan memiliki persepsi yang beragam di aspek kehidupannya tentang penyakit kanker payudara dan pemaknaan persepsi pentingnya melakukan deteksi dini kanker payudara.
Kesimpulan dalam penelitian adalah berbagai pengalaman dengan beban biopsikososiospiritual yang dialami, memunculkan persepsi tentang pentingnya deteksi dini dalam upaya pencegahan kanker payudara
Pengaruh air rebusan daun sirih merah (Piper crocatum) terhadap penurunan gejala fluor albus pada wanita usia subur
Authors: Ernawati Okta , Prasetyaningati Dwi , Rahmawati Anita 
Published: April 2021

Fluor albus dapat ditandai dengan adanya gejala awal berupa cairan yang keluar dari vagina. Pemberian air rebusan daun sirih merah sangat bermanfaat untuk mengurangi gejala fluor albus pada wanita usia subur. Penelitian ini bertujuan untuk mengetahui pengaruh air rebusan daun sirih merah terhadap penurunan gejala fluor albus pada wanita usia subur.
Jenis penelitian ini dengan pra eksperimental mengunakan pendekatan one-group pra-post test design. Populasi penelitian seluruh wanita usia subur sebanyak 50 responden dengan sampel 17 responden. Teknik sampling mengunakan simple random sampling. Variabel independen yaitu daun sirih merah dan variabel dependen yaitu penurunan gejala flour albus. Instrumen penelitian mengunakan lembar observasi, SAK, dan SOP. Pengolahan data editing, coding, skoring, tabulating, dan uji statistik T test.
Hasil penelitian didapatkan 16 responden (94,1%) mengalami penurunan gejala fluor albus dan 1 responden (5,9%) tidak mengalami penurunan gejala fluor albus. Hasil uji statistik p-value = 0,000 dimana p-value < kurang dari 0,05 berarti H0 ditolak dan H1 diterima.
Dari hasil penelitian ini dapat diambil kesimpulan wanita usia subur yang mengalami fluor alus dapat mengaplikasikan air rebusan daun sirih merah sebagai obat non-farmakologis. Ada pengaruh air rebusan daun sirih merah terhadap penurunan gejala fluor albus pada wanita usia subur.
Photodynamic therapy in endodontics: literature review.
Authors: Faria Damasceno Maria Cleyde , do Carmo Araújo Maria Madalena 
Published: April 2021

Endodontic therapy seeks to prevent and when necessary to eliminate endodontic infections. The persistence of microorganisms to the mechanical chemical preparation or the intracanal medication is considered the main cause of the failures of the endodontic treatment. In these cases Enterococcus faecalis is the most commonly found microorganism. Photodynamic therapy (PDT) emerges as a promising adjuvant therapy to conventional endodontic treatment to eliminate these persistent microorganisms. This therapy consists in the association of a specific light source with a photosensitizer in the presence of oxygen, producing cytotoxic species to the microorganisms. Thus, the present article aims at a review of the literature on the use of photodynamic therapy in endodontics, a test that is shown to assist in the preparation of the root canal.
ГИДРОЛИЗ В СИСТЕМЕ «СУЛЬФИД АММОНИЯ +ВОДА», ПРОТЕКАЮЩИЙ В ДВЕ СТУПЕНИ
Authors: Хасанов И.И. , Хасанов А.И. , Тангиева А.М. , Умхаева А.А. , Висеркаев И.И. 
Published: April 2021

Цель работы – показать ошибки, допускаемые при рассмотрении процесса гидролиза. Если рассматривать названия уравнений реакций ионного обмена, отметим, что при написании уравнений этих реакций, называя уравнение реакции ионного обмена (последнее, третье уравнение реакции, в большинстве случаях) – «сокращенное ионное уравнение», отображающее суть реакции ионного обмена, допускается ошибка. Показано, что применение термина «гидролиз» в дословном переводе с греческого как «разложение соли водой» неверно.
Рассмотрены случаи, когда гидролиз в системе «сульфид аммония +вода» осуществляется в две стадии. Вычислены константы и степени гидролиза для всех случаев, проведен сравнительный анализ для них. Рекомендовано учесть следующее:
–	принцип Ле Шателье не применим к процессу гидролиза;
–	при написании выражения для константы гидролиза или константы равновесия химической реакции следует говорить о применении закона (константы) химического равновесия (ЗХР), а не закона действия масс.
A CO-to-H2 Ratio of ≈10−5 toward the Herbig Ae Star HK Ori
Authors: Cauley P. Wilson , France Kevin , Herzceg Gregory J. , Johns-Krull Christopher M. 
Published: April 2021

Abstract
Measurements of gas mass in protoplanetary gas disks form the basis for estimating the conditions of planet formation. Among the most important constraints derived from disk diagnostics are the abundances of gas-phase species critical for understanding disk chemistry. Toward this end, we present direct line-of-sight measurements of H2 and CO, employing UV absorption spectroscopy from Hubble Space Telescope Cosmic Origins Spectrograph to characterize disk composition, molecular excitation temperatures, and spatial distribution in the circumstellar material around the Herbig Ae stars HK Ori and T Ori. We observe strong CO (N(CO) = 1015.5 cm−2; T
rot(CO) = 19 K) and H2 (N(H2) = 1020.34 cm−2; T
rot(H2) = 141 K) absorption toward HK Ori with a CO/H2 ratio of (≡N(CO)/N(H2)) =

× 10−5. These measurements place direct empirical constraints on the CO-to-H2 conversion factor in the disk around a Herbig Ae star for the first time, although there is uncertainty concerning the exact viewing geometry of the disk. The spectra of T Ori show CO (N(CO) = 1014.9 cm−2; T
rot(CO) = 124 K) absorption. Interestingly, we do not detect any H2 absorption toward this star (N(H2) < 1015.9 cm−2). We discuss a potential scenario for the detection of CO without H2, which deserves further investigation. The low abundance ratio measured around HK Ori suggests significant depletion of CO in the circumstellar gas, which conforms with the handful of other recent CO abundance measurements in protoplanetary disks.
Tails: Chasing Comets with the Zwicky Transient Facility and Deep Learning
Authors: Duev Dmitry A. , Bolin Bryce T. , Graham Matthew J. , Kelley Michael S. P. , Mahabal Ashish , Bellm Eric C. , Coughlin Michael W. , Dekany Richard , Helou George , Kulkarni Shrinivas R. , Masci Frank J. , Prince Thomas A. , Riddle Reed , Soumagnac Maayane T. , van der Walt Stéfan J. 
Published: April 2021

Abstract
We present Tails, an open-source deep-learning framework for the identification and localization of comets in the image data of the Zwicky Transient Facility (ZTF), a robotic optical time-domain survey currently in operation at the Palomar Observatory in California, USA. Tails employs a custom EfficientDet-based architecture and is capable of finding comets in single images in near real time, rather than requiring multiple epochs as with traditional methods. The system achieves state-of-the-art performance with 99% recall, a 0.01% false-positive rate, and a 1–2 pixel rms error in the predicted position. We report the initial results of the Tails efficiency evaluation in a production setting on the data of the ZTF Twilight survey, including the first AI-assisted discovery of a comet (C/2020 T2) and the recovery of a comet (P/2016 J3 = P/2021 A3).
An IRTF-iSHELL Survey of 4.52–5.25 μm CO Spectra in Protoplanetary Disks of Intermediate-mass Stars: Preliminary Sample and Analysis
Authors: Abernathy Kirsten M. , Banzatti Andrea , Jensen Stanley , Brittain Sean , Boogert Adwin , Rayner John T. , Bruderer Simon 
Published: April 2021

Abstract
We are conducting a survey of high-resolution near-infrared CO rovibrational spectra in protoplanetary disks around young intermediate-mass stars. We use IRTF-iSHELL with the 0.″375 and 0.″75 slits, providing 4 km s−1 and 6 km s−1 resolution and covering 4.52–5.25 μm in one single exposure. This includes part of the rovibrational R branch and most of the P branch of the CO fundamental band (Δv = 1), one of the best tracers of warm/hot gas in disks. The high quality of the spectra and the large sample covered in this survey will support multiple investigations to study the structure, kinematics, composition, and evolution of the inner 10 au in disks for years to come. The survey currently includes ∼30 stars mostly within 200 pc, complementing extensive imaging campaigns that are observing their disks at optical, infrared, and millimeter wavelengths and revealing structures and planets.