bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors and Protective Immunity Against Rabies in Unvaccinated Butchers Working at Dog Slaughterhouses in Northern Vietnam
Authors: Nguyen Anh Kieu Thi , Vu Anh Hoang , Nguyen Thu Tuyet , Nguyen Dong Vinh , Ngo Giang Chau , Pham Thai Quang , Inoue Satoshi , Nishizono Akira 
Published: August 2021

ABSTRACT.
Vietnam is a rabies-endemic country where eating dog meat is customary. However, the risks of rabies transmission to dog slaughtering and processing workers have not been identified. This study aimed to determine the rabies neutralizing antibody (NTA) and risk factors in dog slaughterers to propose appropriate intervention methods for this occupational group. In 2016, a cross-sectional study on NTA against rabies virus and related factors was conducted among 406 professional dog slaughterers in Vietnam. The participants were interviewed using a structured questionnaire, and their sera were tested for rabies NTA by a rapid focus fluorescence inhibition test. Statistical algorithms were used to analyze the data. The results showed that most of the professional dog butchers (344/406 subjects, 84.7%) had no rabies NTA. Interestingly, 7.8% (29/373) had NTA without a rabies vaccination history. Over 5 years of experience as a dog butcher was positively associated with the presence of NTA in unvaccinated individuals (OR = 6.16, P = 0.001). The NTA in vaccinated butchers was present in higher titer and for longer persistence to those of other previously reported professionals, which is possibly as a result of multiple exposures to low levels of rabies virus antigens during dog slaughtering. Our study demonstrated that professional dog butchers in Vietnam are at a high risk of rabies virus infection, apart from those with common bite experiences. In countries where dog meat consumption is customary, rabies control and prevention activities should focus on safety during dog trading and slaughtering.
Social Stressors, Arboviral Infection, and Immune Dysregulation in the Coastal Lowland Region of Ecuador: A Mixed Methods Approach in Ecological Perspective
Authors: Vega Ocasio Denisse , Stewart-Ibarra Anna M. , Sippy Rachel , Li Christina , McCue Kaitlyn , Bendinskas Kestutis G. , Gump Brooks B. , Cueva-Aponte Cinthya , Ayala Efrain Beltrán , Morrell Craig N. , Dye Timothy D. 
Published: August 2021

ABSTRACT.
Aedes aegypti, the mosquito that transmits arboviral diseases such as dengue (DENV), chikungunya (CHIKV), and Zika viruses (ZIKV), is present in tropical and subtropical regions of the world. Individuals at risk of mosquito-borne disease (MBD) in the urban tropics face daily challenges linked to their socio-environment conditions, such as poor infrastructure, poverty, crowding, and limited access to adequate healthcare. These daily demands induce chronic stress events and dysregulated immune responses. We sought to investigate the role of socio-ecologic risk factors in distress symptoms and their impact on biological responses to MBD in Machala, Ecuador. Between 2017 and 2019, individuals (≥ 18 years) with suspected arbovirus illness (DENV, ZIKV, and CHIKV) from sentinel clinics were enrolled (index cases, N = 28). Cluster investigations of the index case households and people from four houses within a 200-m radius of index home (associate cases, N = 144) were conducted (total N = 172). Hair samples were collected to measure hair cortisol concentration (HCC) as a stress biomarker. Blood samples were collected to measure serum cytokines concentrations of IL-10, IL-8, TNF-α, and TGF-β. Univariate analyses were used to determine the association of socio-health metrics related to perceived stress scores (PSS), HCC, and immune responses. We found that housing conditions influence PSS and HCC levels in individuals at risk of MBD. Inflammatory cytokine distribution was associated with the restorative phase of immune responses in individuals with low-moderate HCC. These data suggest that cortisol may dampen pro-inflammatory responses and influence activation of the restorative phase of immune responses to arboviral infections.
Repeated Ivermectin Treatment Induces Ivermectin Resistance in Strongyloides ratti by Upregulating the Expression of ATP-Binding Cassette Transporter Genes
Authors: Sengthong Chatchawan , Yingklang Manachai , Intuyod Kitti , Haonon Ornuma , Pinlaor Porntip , Jantawong Chanakan , Hongsrichan Nuttanan , Laha Thewarach , Anutrakulchai Sirirat , Cha’on Ubon , Sithithaworn Paiboon , Pinlaor Somchai 
Published: August 2021

ABSTRACT.
Ivermectin (IVM) is a widely used anthelmintic. However, with widespread use comes the risk of the emergence of IVM resistance, particularly in strongyloidiasis. Adenosine triphosphate (ATP)-binding cassette (ABC) transporter genes play an important role in the IVM-resistance mechanism. Here, we aimed to establish an animal experimental model of IVM resistance by frequent treatment of Strongyloides ratti with subtherapeutic doses of IVM, resistance being evaluated by the expression levels of ABC transporter genes. Rats infected with S. ratti were placed in experimental groups as follows: 1) untreated control (control); 2) treated with the mutagen ethyl methanesulfonate (EMS); 3) injected with 100 µg/kg body weight of IVM (IVM); 4) treated with a combination of EMS and IVM (IVM+EMS). Parasites were evaluated after four generations. Extent of IVM resistance was assessed using IVM sensitivity, larval development, and expression of ABC genes. By the F4 generation, S. ratti in the IVM group exhibited significantly higher levels of IVM resistance than did other groups according to in vitro drug-sensitivity tests and inhibition of larval development (IC50 = 36.60 ng/mL; 95% CI: 31.6, 42.01). Expression levels of ABC isoform genes (ABCA, ABCF, and ABCG) were statistically significantly higher in the IVM-resistant line compared with the susceptible line. In conclusion, IVM subtherapeutic doses induced IVM resistance in S. ratti by the F4 generation with corresponding upregulation of some ABC isoform genes. The study provides a model for inducing and assessing drug resistance in Strongyloides.
Impact of Recent SARS-CoV-2 Infection on the Course and Severity of Dengue in Children: A Prospective Observational Study from North India
Authors: Ravikumar Namita , Randhawa Manjinder Singh , Nallasamy Karthi , Angurana Suresh Kumar , Kumar Mahendra , Mohi Gursimran Kaur , Ratho Radha Kanta , Jayashree Muralidharan 
Published: August 2021

ABSTRACT.
In 2020, a considerable overlap occurred between the COVID-19 pandemic and seasonal dengue transmission in India. This study aimed to evaluate the effects of acute or recent infection with SARS-CoV-2 on the course and outcomes of dengue fever in children. We prospectively enrolled 44 children with a clinical and laboratory diagnosis of dengue fever. Assessment of acute and recent SARS-CoV-2 infection was done using reverse transcription–polymerase chain reaction and IgG antibody through ELISA. Children were grouped based on evidence of SARS-CoV-2 exposure and clinical severity, and outcomes were compared. The median age of the study cohort was 96 months (interquartile range [IQR]: 69–129 months). Fever (98%), vomiting (78%), abdominal pain (68%), hepatomegaly (68%), and edema (32%) were the common features. About two-thirds (N = 30) had severe dengue; 20 (45%) had dengue shock. Liver dysfunction (58%) and acute kidney injury (25%) were other major organ dysfunctions. Nineteen (43%) children stayed in the pediatric intensive care unit for a median duration of 5 days (IQR: 2–11 days). None had acute SARS-CoV2 infection; however, IgG against SARS-CoV-2 was detected in 15 (34%) cases. Children with recent exposure to SARS-CoV-2 showed a trend toward a lower incidence of acute kidney injury, fewer organ dysfunctions, and a lower frequency of invasive ventilation. Four children (9%) died; none of the deaths were in the SARS-CoV-2–exposed group. The present study exposes preliminary evidence that dengue fever might follow a less severe course in children with recent exposure to SARS-CoV-2 infection. However, it is pertinent to understand the antigenic similarity and cross-protective antibody response between the two viruses and their clinical relevance.
FUNCIONARIOS INTERINOS Y EMPLEO PÚBLICO: ANÁLISIS GENERAL DE SU CONTROVERTIDO RÉGIMEN JURÍDICO
Authors: BRUFAO CURIEL PEDRO 
Published: August 2021

Este trabajo sistematiza el complicado, cambiante y contradictorio régimen jurídico de los funcionarios interinos en España. El abuso de esta figura y los procesos de funcionarización han desdibujado los límites entre unos y otros, a lo que se le suma el que en ciertos sectores profesionales como el sanitario y el educativo la alta tasa de temporalidad en el empleo pone en riesgo no solo los derechos profesionales, sino la estabilidad y la calidad del servicio público. Con el fin de exponer con claridad los detalles de esta preocupante situación jurídica que afecta a decenas de miles de interesados, mostramos críticamente el régimen aplicable a los funcionarios interinos, moldeado por el Derecho europeo y la jurisprudencia constitucional y contencioso-administrativa, desde su nombramiento hasta las condiciones de cese y la eventualidad de una indemnización, pasando por las competencias atribuidas y las vicisitudes de su carrera profesional.Lan honek Espainiako bitarteko funtzionarioen araubide juridiko zaila, aldakorra eta kontraesanezkoa sistematizatzen du. Figura horren gehiegizko erabilerak eta funtzionario bilakatzeko prozesuek lausotu egin dituzte batzuen eta besteen arteko mugak, eta horri gehitu behar zaio lanbide-sektore batzuetan, hala nola osasunaren eta hezkuntzaren arloetan, enpleguaren aldi baterakotasun tasa handiak profesionalen eskubideak ez ezik, zerbitzu publikoaren egonkortasuna eta kalitatea ere jartzen dituela arriskuan. Milaka interesdunei eragiten dien egoera juridiko kezkagarri horren xehetasunak argi eta garbi adierazi nahian, kritikoki azalduko dugu bitarteko funtzionarioei aplikatu beharreko araubidea, Europako zuzenbideak eta konstituzioko eta administrazioarekiko auzien jurisprudentziak moldatua; hau da, haiek izendatzea zein kargutik kentzeko baldintzak eta balizko kalte-ordainak, bai eta haiei esleitutako eskumenak eta lanbide-karreraren gorabeherak.This essay analyzes the confusing, changing and contradictory legal regime of interim or temporary civil servants in Spain. The abuse played upon this figure and the schemes related to turning public employees into civil servants have indeed blurred the limits raised between them, in addition to the risks posed by the highly temporality levels, specially suffered by public health and educational services, to both labour rights and job stability and quality. Thousands of public jobs are affected by this situation, and aiming at making clear the details of that situation a review of its legal regime is shown in this paper, framed by the EU law and constitucional and administrative case-law, beginning with job appointments and ending up with their dismissal and severance pay, along with their authority, jurisdiction, and career development.
SOBRE LA ADMINISTRACIÓN COMPETENTE PARA SANCIONAR A LOS FUNCIONARIOS DE ADMINISTRACIÓN LOCAL CON HABILITACIÓN DE CARÁCTER NACIONAL INTERINOS
Authors: EZQUERRA HUERVA ANTONIO 
Published: August 2021

El presente trabajo tiene por objeto el estudio de la legitimidad
jurídica de los arts. 61 y 62 del Real Decreto 128/2018, de 16 de marzo, por el que
se regula el régimen jurídico de los funcionarios de Administración Local con habilitación
de carácter nacional, los cuales atribuyen la potestad disciplinaria sobre los funcionarios de administración local con habilitación de carácter nacional a administraciones
públicas distintas según se trate de funcionarios de carrera o interinos.
La conclusión que se sostiene es que dicha diferenciación constituye un injustificado
trato discriminatorio a los funcionarios interinos.
Lan honek xedetzat dut martxoaren 16ko 128/2018 Errege Dekretuaren
61. eta 62. artikuluen zilegitasun juridikoa aztertzea (Estaturako gaikuntza
duten toki-administrazioko funtzionarioen araubide juridikoa arautzen du Errege
Dekretu horrek). Artikulu horiek administrazio publiko ezberdinei ematen die Estatuko
gaikuntza duten toki-administrazioko funtzionarioen gaineko diziplina-ahala,
azken horiek karrerako edo bitarteko funtzionarioak diren. Defendatzen duen ondorioa
da bereizketa hori bitarteko funtzionarioen aurkako diskriminaziozko tratu
bidegabe bat dela.
This paper analyses the legal legitimacy of articles 61 and 62
of the Royal Decree 128/2018, of March 16, regulating the legal regime of Local
Administrations¿ civil servants with a national habilitation. Articles 61 and 62
attribute disciplinary power over the aforementioned officials to different Public
Administrations depending on whether they are permanent or temporary civil
servants. The analysis leads to the conclusion that such a distinction constitutes a
discriminatory treatment towards temporary civil servants.
Edukasi Tourism Branding Berbasis Kearifan Lokal di SMA N 1 Pangandaran, Kabupaten Pangandaran, Jawa Barat
Authors: Swaradesy Rufus Goang , Shafanissa Winna , Nagara Martien Roos , Fitra Annisa 
Published: August 2021

This research aims to help the community in the Pangandaran region solve problems to developing and promoting cultural tourism based on local wisdom as well as nature tourism. This place of community service is located at SMA N 1 Pangandaran as well as Batu Kalde site in Babakan village, Pangandaran District, Pangandaran Regency, West Java. The students involved are grade X and XI students. The problem in Pangandaran tourism is the focus on natural attractions in the form of beaches, whereas many cultural sites are found in Pangandaran such as batu kalde, Goa Jepang, Lingga Kencana, and others. This is compounded by most students do not yet know the existence of such cultural sites. The purpose of this community service is to help introduce cultural tourism in Pangandaran by providing some tourism branding solutions to facilitate tourism promotion. The cultural tourism promotion solution provided is to introduce several cultural sites, provide documenting materials in the form of photos and videos and provide editing training using gadgets owned to further create branding or tourism icons as a medium of promotion of cultural tourism in Pangandaran. Abstrak: Penelitian ini bertujuan untuk memenuhi tugas dalam kegiatan pengabdian keapda masyarakat supaya membantu masyarakat di wilayah Pangandaran memecahkan masalah berkaitan kepariwisataan supaya di samping mengembangkan dan mempromosikan wisata alam, dikembangkan juga wisata budaya berdasarkan kearifan lokal. Tempat kegiatan pengabdian masyarakat ini berada di SMA N 1 Pangandaran serta situs kepurbakalan Batu Kalde di desa Babakan, Kecamatan Pangandaran, Kabupaten Pangandaran, Jawa Barat. Siswa yang dilibatkan adalah siswa kelas X dan XI. Permasalahan di pariwisata Pangandaran adalah terfokusnya pada objek wisata alam berupa pantai, padahal banyak situs budaya yang terdapat di Pangandaran seperti situs Batu kalde, Goa Jepang, Lingga Kencana, dan lain-lain. Hal ini diperparah dengan Sebagian besar siswa belum tau keberadaan situs budaya tersebut. Tujuan diadakan pengabdian masyarakat ini adalah membantu memperkenalkan wisata budaya di Pangandaran dengan memberikan beberapa solusi branding kepariwisataan untuk mempermudah dalam hal promosi wisata. Solusi promosi wisata budaya yang diberikan yaitu dengan mengenalkan beberapa wisata budaya, memberikan materi pendokumentasian baik berupa foto dan video serta memberikan pelatihan edit menggunakan gadget yang dimiliki untuk selanjutnya membuat branding atau ikon pariwisata sebagai media promosi pariwisata budaya di Pangandaran.
Inovasi Strategi Pemasaran Sentra Industri Brem Madiun Dalam Menghadapi Persaingan di Masa Pandemi Covid 19
Authors: Ari Kadi Dian Citaningtyas , Fauzi Rizal Ula Ananta , Riziq Kamal Ali , Pamungkas Aji , Rossanto Selly Andan Ria 
Published: August 2021

In the economy, the industrial sector has the most important role in our country. The existence of an industry can increase regional income and can create jobs. One of the industrial centres in Madiun is the industrial centre for making Brem, who does not know this particular dish. Brem is processed by fermentation of cooked glutinous rice and mixed with yeast which helps to produce a tape which then takes the water to make a brem. In the village of Bwisata Kec. Wonoasri Madiun is one of the centres in making the brem, one of which is Brem Candi Mas. And we make observations there. This program aims to add insight into MSMEs in Madiun Regency, especially in the Brem Candi Mas UMKM Center, increase sales and income so that they can survive the economic crisis caused by the Covid 19 pandemic, and create new marketing strategies. This service activity is assisted by students as entrepreneurial knowledge. The innovation made is helping the digital marketing process, namely through social media such as Instagram, Facebook, and we have created a website so that the current marketing process does not only depend on manual marketing from store to store but is more effective with online marketing. Abstrak. Dalam perekonomian sektor industri mempunyai peranan yang paling penting di negara kita ini. Keberadaan sebuah industri dapat meningkatkan suatu pendapatan daerah dan dapat membuka lapangan pekerjaan. Salah satu sentra industri yang berada di madiun adalah sentra industri pembuatan brem, siapa yang tidak mengenal panganan khas yang satu ini. Brem merupakan olahan dengan cara fermentasi beras ketan yang dimasak dan dalam pembuatannya di campur dengan ragi yang membantu agar menghasilakan sebuah tape yang selanjutnya diambil air nya untuk dijadikan sebuah brem. Di Desa Bancong Kec. Wonoasri Madiun adalah salah satu sentra dalam pembuatan brem tersebut, salah satunya adalah brem candi mas. Dan kita melakukan observasi disana. Progam ini bertujuan untuk menambah wawasan tentang UMKM di kabuoaten madiun khusunya di Centra UMKM Brem Candi Mas ini,meningkatkan penjualan dan pendapatan agar tetap bisa bertahan dalam krisis ekonomi akibat dari pandemi Covid 19,serta membuat strategi pemasaran yang baru. Kegiatan pengabdian ini dibantu oleh para mahasiswa sebagai pengetahuan berwirausaha. Inovasi yang dilakukan adalah membantu proses pemasaran digital yaitu melalui media sosial seperti instagram,facebook,dan kami buatkan website sehingga proses pemasaran dimasa saat ini tidak hanya bergantung pada pemasaran manual dari toko ke toko namun lebih efektif dengan pemasaran online.
Peningkatan Time Management Skills Masyarakat Kota Padangsidimpuan di Masa Pandemi COVID-19
Authors: Napitupulu Rodame Monitorir 
Published: August 2021

Fenomena yang dihadapi oleh semua orang di masa pandemi COVID-19 ini adalah kesulitan mengelola waktu dengan benar sehingga tujuan yang diharapkan dapat tercapai. Padahal hal tersebut merupakan sebuah keahlian (skill) yang menjadi mutlak diperlukan terkait keberhasilan meraih tujuan. Oleh karena itu, dalam Pengabdian Kepada Masyarakat (PKM) ini, upaya peningkatan time management skills di masa pandemi COVID-19 saya lakukan agar dapat memberikan pemahaman dan praktik dalam mengatur waktu dengan benar. Manfaatnya diharapkan dapat diterapkan secara langsung dalam kehidupan sehari-hari baik dalam kondisi pandemi COVID-19 maupun tidak. Metode pelaksanaan kegiatan ini terdiri dari 2 tahapan yaitu: penyusunan materi dan penyampaian melalui siaran radio setempat yaitu: RAU di 105 FM Kota Padangsidimpuan. Materi disusun dengan mengikuti rundown acara talkshow di RAU FM sehingga mudah dipahami dan dipraktikkan dengan berbagai tips dan berbagi pengalaman. Harapannya, seluruh pendengar yaitu masyarakat Kota Padangsidimpuan dapat memahami apa itu time management dan bagaimana mengatur waktu dengan sebaik-baiknya sehingga tujuan setiap orang dapat tercapai. Time management skills dapat berkontribusi secara nyata dalam kehidupan sehari-hari. Abstract: The phenomenon faced by everyone during the COVID-19 pandemic is the difficulty of managing time properly so that the expected goals can be achieved. Even though this is a skill that is absolutely necessary in relation to the success of achieving goals. Therefore, in this Community Service (PKM), I made efforts to increase time management skills during the COVID-19 pandemic so that I could provide understanding and practice in managing time properly. It is hoped that the benefits can be applied directly in everyday life both in the conditions of the COVID-19 pandemic or not. The method of implementing this activity consists of 2 stages, namely: preparation of material and delivery through local radio broadcasts, namely: RAU at 105 FM Padangsidimpuan City. The material was prepared by following the rundown of the talk show at RAU FM so that it is easy to understand and practice with various tips and sharing experiences. The hope is that all listeners, namely the community of Padangsidimpuan City, can understand what time management is and how to manage time properly so that everyone's goals can be achieved. Time management skills can contribute significantly in everyday life.
AGRICULTURA URBANA E ALIMENTAÇÃO: HORTAS URBANAS EM PALMAS-TO
Authors: TATIANA DE OLIVEIRA SOUSA  , JOÃO APARECIDO BAZZOLI  , CECILIA DELGADO  
Published: August 2021

Este estudo objetivou analisar hortas urbanas de um projeto desenvolvido pela Prefeitura de Palmas, capital do Tocantins. Pretendeu-se compreender seus desafios no processo de implantação e manutenção, suas dificuldades administrativas para gerir a produção e a distribuição, bem como suas representações socioeconômicas de famílias envolvidas nessa atividade. A metodologia exploratória aplicada ao estudo implicou o levantamento e a análise do perfil e das práticas dos horticultores responsáveis pelas hortas estudadas. Justificou-se o estudo por entender que é importante fomentar a replicação de hortas urbanas para o reconhecimento dessa atividade, considerando o seu potencial como ferramenta para a promoção do desenvolvimento local, geração de renda complementar, interação social dos envolvidos e o resgate cultural da produção de alimentos saudáveis para consumo próprio. Concluiu-se com o estudo que as hortas urbanas promovem a inclusão social das famílias envolvidas, principalmente em relação aos grupos de pessoas de baixa renda, desempregados, idosos e mulheres.
Palavras-chave: Agricultura Urbana. Hortas Urbanas. Produção Familiar em Pequena Escala. Palmas-TO.
NĂNG LỰC QUẢN LÝ CỦA CÁC ĐIỀU DƯỠNG TRƯỞNG KHOA LÂM SÀNG CỦA MỘT SỐ BỆNH VIỆN CÔNG LẬP TUYẾN TỈNH LÀO CAI, 2020
Authors: Ngọc Bích Nguyễn , Tà Phìn Lù 
Published: August 2021

Năng lực quản lý của điều dưỡng trưởng là một yếu tố quan trọng để tận dụng mọi nguồn lực tại khoa và bệnh viện để phục vụ và chăm sóc người bệnh. Nghiên cứu mô tả năng lực quản lý của điều dưỡng trưởng các khoa lâm tại các bệnh viện công lập tuyến tỉnh Lào Cai được triển khai năm 2020.Thiết kế nghiên cứu cắt ngang thực hiện tại 05 Bệnh viện tuyến tỉnh của tỉnh Lào Cai từ tháng 6/2020 – 11/2020. Số liệu định lượng thu thập từ bộ câu hỏi phát vấn 54 cán bộ y tế là điều dưỡng trưởng các khoa lâm sàng, năng lực quản lý được đánh giá dựa trên mức độ tự tin khi thực hiện công việc, nghiên cứu cũng đã tiến hành phỏng vấn sâu trên các điều dưỡng trưởng.Kết quả nghiên cứu cho thấy Tỷ lệ điều dưỡng trưởng khoa đủ năng lực quản lý chung vẫn ở mức trung bình là 57,4%. Nghiên cứu khuyến nghị cần tiếp tục đào tạo bồi dưỡng về kiến thức và kỹ năng quản lý điều dưỡng đồng thời có các hình thức giám sát hỗ trợ.