bluuebunny/crossref_metadata_2025_split huggingface dataset:
Classifying subtypes and predicting survival of renal cell carcinoma using histopathology image-based deep learning
Authors: Wang Fei , Geng Yuanzhe , Wang Ting , Zhao Ke , Xu Bin , Zhang Dachuan , Cai Hongzhou , Yuan Qinbo , Lu Hang , Zhang Yue , Li Xu , Sun Yangyang , Gong Hang , Alolga Raphael N , Fan Xiangshan , Ma Gaoxiang , Qi Lian-Wen 
Published: May 2021

Abstract
Classifying histopathological subtypes and predicting survival of renal cell carcinoma (RCC) patients are critical steps towards treatment. In this work, we first proposed a deep learning method involving patch-based segmentation, intelligent feature extraction and heatmap visualization for classifying RCC into clear cell RCC, papillary RCC, chromophobe RCC, and adjacent benign tissue. This algorithm was trained and validated using 2,374,446 patches, 6,340 whole-slide images, 2,399 patients from The Cancer Genome Atlas and 6 independent centers. The classifiers provided areas under the curves of 0.979 to 0.996 in the internal phase, and 0.914 to 0.995 in the 6-center external phase. Furthermore, a modified deep learning approach comprising automated detection of regions of interest, patch-level learning, and morphological features-based risk scoring was developed for predicting survival of clear cell RCC patients. The prognostication model provided a hazard ratio for poor versus good prognosis of 2.63 [95% confidence interval (CI) 1.53–4.50, P = 4.35e-4] in the testing set, and 2.57 [95% CI 1.43–4.64, P = 1.68e-3] in an independent validation set using multivariable analyses. In conclusion, the developed histopathology image-based deep learning frameworks have the clinical potential to assist pathologists in systematically evaluating histological information of RCC patients.
Constitutive modeling for the mechanical behavior of rubber with filler particles
Authors: Gour Sankalp , Singh Deepu Kumar , Kumar Deepak , Yadav Vinod 
Published: May 2021

Abstract
The present study deals with the constitutive modeling for the mechanical behavior of rubber with filler particles. An analytical model is developed to predict the mechanical properties of rubber with added filler particles based on experimental observation. To develop the same, a continuum mechanics-based hyperelasticity theory is utilized. The model is validated with the experimental results of the chloroprene and nitrile butadiene rubbers filled with different volume fractions of carbon black and carbon nanoparticles, respectively. The findings of the model agree well with the experimental results. In general, the developed model will be helpful to the materialist community working in characterizing the material behavior of tires and other rubber-like materials.
The diversity of unique 1,4,5,6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid coding common genes and novel Universal stress protein in Ectoine TRAP cluster (UspA) in 32 Halomonas species
Authors: Rekadwad Bhagwan , Li Wen-Jun , PD Rekha 
Published: May 2021

Abstract
Objectives To decipher the diversity of unique ectoine-coding housekeeping genes in the genus Halomonas.Results In Halomonas, 1,4,5,6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid has a crucial role as a stress-tolerant chaperone, a compatible solute, a cell membrane stabilizer, and a reduction in cell damage under stressful conditions. Apart from the current 16S rRNA biomarker, it serves as a blueprint for identifying Halomonas species. Halomonas elongate 1H9 was found to have 11 ectoine-coding genes. The presence of a superfamily of conserved ectoine-coding among members of the genus Halomonas was discovered after genome annotations of 93 Halomonas spp. As a result of the inclusion of 11 single copy ectoine coding genes in 32 Halomonas spp., genome-wide evaluations of ectoine coding genes indicate that 32 Halomonas spp. have a very strong association with Halomonas elongata 1H9, which has been proven evidence-based approach to elucidate phylogenetic relatedness of ectoine-coding child taxa in the genus Halomonas. Total 32 Halomonas species have a single copy number of 11 distinct ectoine-coding genes that help Halomonas spp. produce ectoine under stressful conditions. Furthermore, the existence of the Universal stress protein (UspA) gene suggests that Halomonas species developed directly from primitive bacteria, highlighting the role of Halomonas species in evolutionary terms.
What Impact has SARS-CoV-2/Covid-19 Pandemic on Healthcare Workers (HCWs) Mortality &amp; Infections across 36 states &amp; union territories of India? How to prevent mortality &amp; morbidity of HCWs?
Authors: Kumar Piyush 
Published: May 2021

Abstract
Background

The ongoing coronavirus pandemic caused by SARS-CoV-2/covid-19/novel coronavirus is an acute infectious communicable disease spreading mainly via respiratory, eye, mouth and other possible routes from person to person as well as through contact with infected non living objects. The pandemic has massively increased healthcare systems burden due to high hospitals admission rate, infection rates, morbidity, and mortality. QALY (quality adjusted life years) & DALY (disability adjusted life years) are also important for consideration of impact of this pandemic. The healthcare systems is under constant massive pressure to halt the spread of the novel coronavirus & a huge part of this responsibility is being shouldered by frontline health care workers including doctors, nurses, paramedical workers, ASHAs and Anganwadi services etc. Hence HCWs are inevitably and routinely exposed to the virus hence naturally are at high risk of infection, possible mortality & morbidities.
Objectives

The key objective is to find out impact of SARS-CoV-2/Covid-19 Pandemic on Healthcare Workers (HCWs) Mortality & Infections across 36 states & union territories of India. What are the reasons of mortality and morbidity & How to prevent mortality & morbidity of HCWs? Methodology/settings & design (search strategy-Research
Methods):

Several databases were searched for deaths of HCWs in India between January 2019 and 18th May 2021, including MoHFW website, PUBMED, WHO COVID-19 database, COVID-19 Study Register, and Google scholar. The search terms used were: “healthcare providers /health care workers/nurses- death in India due to COVID-19”, “SARS-CoV-2”, “Coronavirus,” using Google search. Whatever data obtained is tabulated.
Results

There is increase in mortality of HCWs in India. The data is not available completely in my search. Beside increased death I have found a lot of controversy and questions raised on the issue of this data. There is lot of discrepancy in data given by Government and other sources. According to the Indian Medical Association, 244 doctors have lost their lives due to Covid in the second wave. Of them, 50 deaths were recorded on Sunday. The highest number of fatalities have been reported from Bihar (69) followed by Uttar Pradesh (34) and Delhi (27).
Conclusion

The government and other agencies should collect and provide the data publicly so that it can be analysed by different sections of researchers to give feedback which will help in making policies helpful to protect HCWs. A large number of medical staffs are infected due to the lack of adequate protection. Currently, the COVID-19 pandemic is growing day by day with lack of essential facilities for treatment. Some experts have warned of a possible third wave of COVID-19.
Projected changes in temperature and precipitation over mainland Southeast Asia by CMIP6 models
Authors: Supharatid S. , Nafung J. , Aribarg T. 
Published: May 2021

AbstractFive mainland SEA countries (Cambodia, Laos, Myanmar, Vietnam, and Thailand) are threatened by climate change. Here, the latest 18 Coupled Model Intercomparison Project Phase 6 (CMIP6) is employed to examine future climate change in this region under two SSP-RCP (shared socioeconomic pathway-representative concentration pathway) scenarios (SSP2-4.5 and SSP5-8.5). The bias-corrected multi-model ensemble (MME) projects a warming (wetting) over Cambodia, Laos, Myanmar, Vietnam, and Thailand by 1.88–3.89, 2.04–4.22, 1.88–4.09, 2.03–4.25, and 1.90–3.96 °C (8.76–20.47, 12.69–21.10, 9.54–21.10, 13.47–22.12, and 7.03–15.17%) in the 21st century with larger values found under SSP5-8.5 than SSP2-4.5. The MME model displays approximately triple the current rainfall during the boreal summer. Overall, there are robust increases in rainfall during the Southwest Monsoon (3.41–3.44, 8.44–9.53, and 10.89–17.59%) and the Northeast Monsoon (−2.58 to 0.78, −0.43 to 2.81, and 2.32 to 5.45%). The effectiveness of anticipated climate change mitigation and adaptation strategies under SSP2-4.5 results in slowing down the warming trends and decreasing precipitation trends after 2050. All these findings imply that member countries of mainland SEA need to prepare for appropriate adaptation measures in response to the changing climate.
Very Early Onset of ATTRE89Q Amyloidosis in a Homozygous Patient
Authors: Russo Massimo , Cucinotta Francescopaolo , Gentile Luca , Fabrizi Gian Maria , Taioli Federica , Vita Giuseppe , Toscano Antonio , Mazzeo Anna 
Published: May 2021

Case Presentarion:
Hereditary transthyretin amyloidosis is a progressive, fatal disease that generally involves the peripheral nervous system, the autonomic nervous system, and the heart. It is autosomal dominant with different penetrance depending on the mutation and the genetic background. Many other missense mutations of the TTR gene may cause the disease. Being an overall rare disease is very rare to observe the condition of homozygosity. In particular, cases of homozygosity have been described in patients with ATTRV30M and ATTRV122I amyloidosis. In the former, the phenotype does not seem to be aggravated, having an age of onset and disease course that does not appear to differ from those of heterozygotes, while in the latter, the onset appears to be earlier.

Conclusion:
We report the first case of ATTRE89Q amyloidosis in a patient that was homozygous for the E89Q mutation in the TTR gene. The clinical phenotype resulted in the earlier disease onset reported in this form of amyloidosis, suggesting that the homozygous condition may be prognostically negative.
Antecedents and Implications of Innovation Capability: Empirical Study of Bakpia MSMEs in Yogyakarta
Authors: Nurhayati Baroroh , Kusmantini Titik , Wahyuningsih Tri 
Published: May 2021

Introduction/Main Objectives: This research examines the antecedents and implications of innovation capability, empirically. The outcomes aim at contributing to the knowledge and understanding about the main driver of innovation capability. Background Problems: Yogyakarta is known for its many and varied charms, its tourist attractions, the availability of facilities and infrastructure to support tourism, such as souvenir sellers. But there is known that number of total foreign and domestic tourists has been a decrease in 2018 (Semester I by 11.51% and II by 3.33%), also in 2019 (Semester I by 11.23%). This is a challenge for MSMEs in the tourism sector and MSMEs in other sectors that support tourism, such a souvenir seller. Bakpia is one of the well-known products of the food and beverage sector in Yogyakarta often bought for souvenirs. The Bakpia MSMEs’ innovations were triggered by competition among the Bakpia producers in Yogyakarta. Therefore, every Bakpia MSME must be competitive to survive in the market. Thus, there is a need to improve their innovation capability, which will impact the innovation performance of the Bakpia MSMEs in Yogyakarta. There is a gap in the research regarding the influence of the factors that are predicted to build innovation capability. Novelty: Previous studies’ results indicate that the influence of knowledge donating and knowledge collecting about innovation performance is not yet conclusive. Therefore, this study aims to fill the gap in the previous research by examining the role of capability as a mediating between knowledge sharing process (knowledge donating and knowledge collecting) to innovation performance. Research Methods: Forty-eight items of data were obtained from Bakpia MSMEs in Yogyakarta through a survey conducted by distributing questionnaires directly to them. The data were analyzed using PLS-SEM via SmartPLS version 3.3.2. Findings/Results: This study shows that the direct and indirect effects of sharing knowledge (which includes donating and collecting knowledge) about innovation performance are found to be positive but not significant. The results also indicate that innovation capability does not significantly mediate knowledge donating and knowledge collecting about innovation performance. Meanwhile, the influence of innovation capability on innovation performance was found to be positive and significant. Conclusion: The antecedents are insignificant for innovation capability, but the antecedent’s constructs still act as a driver to build innovation capability.
Something special? De transatlantiske bånd og deres holdbarhed
Authors: Niels Byrjalsen  
Published: May 2021

De nære relationer mellem USA og Europa har i årtier været et centralt element i international politik. Men hvor kommer det transatlantiske forholds holdbarhed og modstandskraft fra? Dette spørgsmål optager mange forskere og aktualiseres nu af de igangværende forskydninger i verdenspolitikken. Bogessayet diskuterer derfor, hvordan de to bøger Special Relationships in World Politics (Haugevik, 2018) og Enduring Alliance (Sayle, 2019) fremmer vores viden om de bånd, der knytter staterne i det nordatlantiske område. Haugevik undersøger bilaterale amerikansk-britiske og britisk-norske ’specielle forhold’, mens Sayle ser nærmere på det multilaterale samarbejde i NATO. De tilbyder begge interessante teoretiske argumenter om samspillet mellem diplomatisk praksis og nationale politiske dynamikker samt imponerende empiriske analyser, som underbygger deres pointer. De to bøger rejser samtidig også nye vigtige spørgsmål, herunder om de indbyggede spændinger i liberale normer og værdier samt om betydningen af tillid for det transatlantiske forholds holdbarhed.
Abstract in English: Something Special? The Transatlantic Ties and Their EnduranceFor several decades, the close relationship between the United States and Europe has been a key aspect of international politics. But what are the sources of the endurance and resilience of transatlantic ties? This question preoccupies researchers, and its salience is growing in light of current shifts in world politics. Accordingly, the book essay discusses how the two books Special Relationships in World Politics (Haugevik, 2018) and Enduring Alliance (Sayle, 2019) contribute to our knowledge about the international ties of the North Atlantic area. Haugevik examines bilateral American-British and British-Norwegian ‘special relationships’, while Sayles studies multilateral cooperation in NATO. They both offer interesting theoretical arguments about the interplay between diplomatic practice and national political dynamics. Moreover, they provide impressive empirical analyses to support their claims. At the same time, the two books raise new important questions, e.g. about the built-in tensions in liberal norms and values as well as about the significance of trust for enduring transatlantic ties.
To Delegate or Redelegate: Is That the Question?
Authors: Halper Thomas 
Published: May 2021

Abstract
Conflicts between those supporting and opposing congressional redelegation to executive agencies go back to the earliest days of the Republic, but given the enormous development of the administrative state, now raise issues of great practical importance. The arguments back and forth implicate abstract notions of democracy, efficiency, and judicial power, though typically partisan and other self interested considerations actually drive the debate. The future is likely to see some retrenchment, but not wholesale rejection of redelegation, as the massive and unpredictable consequences would deter courts from acting.
The Active Future for the Passive Therapist
Authors: Nicholls David A. 
Published: May 2021

Synopsis In this Viewpoint, I argue that we may be at an inflection point in the course of the physical therapy profession. The current debate over “active” and “passive” therapies highlights once again how much physical therapy practices reflect shifting cultural and social attitudes. Calls for less passive management of musculoskeletal conditions and more self-management reflect the neoliberal desire for autonomous, entrepreneurial, endlessly resilient, and self-sufficient subjects who will shift the burden of health care from the state to the individual. Such shifts in practice have important implications for therapists and clients alike, and practitioners should give careful thought to what is going on at a deeper societal level when they contemplate profound changes in practice. J Orthop Sports Phys Ther 2021;51(7):318–321. Epub 15 May 2021. doi:10.2519/jospt.2021.10536
Move It or Lose It? The Effect of Early Active Movement on Clinical Outcomes Following Rotator Cuff Repair: A Systematic Review With Meta-analysis
Authors: Silveira Anelise , Luk Joel , Tan Maria , Kang Sung Hyun , Sheps David M. , Bouliane Martin , Beaupre Lauren 
Published: May 2021

Objective To assess the effect of early active shoulder movement after rotator cuff repair, compared to delayed active shoulder movement, on clinical outcomes, rotator cuff integrity, and return to work. Study Design Intervention systematic review. Literature Search We searched 14 databases in November 2017 and updated the search in December 2018 and February 2020. Study Selection Criteria We included comparative studies that assessed the effect of early active shoulder movement versus delayed active shoulder movement following rotator cuff repair. Data Synthesis Means and SDs were used to calculate weighted mean differences and 95% confidence intervals for outcomes of interest. The sensitivity analysis included only randomized controlled trials and was performed when heterogeneity among studies was statistically significant. Results Eight studies with a total of 756 participants (early active shoulder movement, n = 379; delayed active shoulder movement, n = 377) were included. There was high-certainty evidence favoring early active movement for forward flexion (6 weeks), abduction (6 weeks), and external rotation (6 weeks and 3 and 6 months) postsurgery. There was moderate-certainty evidence of worse Western Ontario Rotator Cuff Index score (6 weeks) for the early active movement group, and no difference in rotator cuff integrity between the early and delayed active movement groups. There were no group differences for all other outcomes. Conclusion Patients who commenced active shoulder movement early after rotator cuff repair had greater shoulder range of motion and worse shoulder-specific quality of life after surgery than patients who delayed active shoulder movement. However, the group differences did not appear to be clinically important, and rotator cuff integrity was similar. J Orthop Sports Phys Ther 2021;51(7):331–344. Epub 15 May 2021. doi:10.2519/jospt.2021.9634
Fear Avoidance Predicts Persistent Pain in Young Adults With Low Back Pain: A Prospective Study
Authors: Smith Jo Armour , Russo Lindsay , Santayana Noel 
Published: May 2021

Objectives To (1) quantify relationships between low back pain (LBP) symptoms, physical activity, and psychosocial characteristics in young adults and (2) identify subclasses of young adults with distinct pain trajectories. Design Prospective cohort study with 12-month follow-up. Methods One hundred twenty adults (mean ± SD age, 20.8 ± 2.6 years; 99 women) participated. Participants completed a baseline survey that measured anxiety, depression, fear avoidance, quality of life, and history and impact of any LBP. Participants completed follow-up surveys every 3 months for 1 year. Subclasses based on pain trajectories over time were identified using latent class analysis, and predictors of class membership at baseline were assessed. Results Individuals with LBP at baseline had lower physical quality-of-life scores than back-healthy participants (P = .01). Subclass 1 (25% of individuals with LBP) had persistent moderate-to-high pain intensity over the 1-year study period. Subclass 2 (75% of individuals with LBP) had significantly improving pain over the 1-year study period. Higher fear avoidance (physical activity subscale) and pain interference at baseline were associated with greater odds of membership in subclass 1 (odds ratio = 1.2; 95% confidence interval: 1.0, 1.3 and odds ratio = 1.4; 95% confidence interval: 1.1, 1.6, respectively). Conclusion Most young adults with LBP had symptoms that improved over time. Levels of fear avoidance and pain interference may help to identify individuals at risk of persistent pain early in the lifespan. J Orthop Sports Phys Ther 2021;51(8):383–391. Epub 15 May 2021. doi:10.2519/jospt.2021.9828
Implementasi Kebijakan dan Program Corporate Social Responsibility (CSR) Perusahaan Perkebunan Kelapa Sawit Di PT Perkebunan Nusantara V Provinsi Riau
Authors: Haq Agung Nur Haq , Basuni Sambas , Sunkar Arzyana 
Published: May 2021

Provinsi Riau menurut BPS tahun 2017 merupakan provinsi dengan luas perusahaan sawit terbesar di Indonesia sehingga implementasi kebijakan CSR paling banyak dilakukan oleh perusahaan kelapa sawit di Provinsi Riau. Tujuan penelitian ini adalah mengukur kinerja implementasi kebijakan dan program CSR perusahaan perkebunan kelapa sawit. Penelititan ini dilakukan pada perusahaan BUMN (PTPN V) dengan mengambil empat contoh unit kebun berdasarkan purposive sampling yang dilihat dari perbedaan lokasi kehidupan masyarakat, 3 unit kebun berada di Kabupaten Kampar, dan satu unit kebun di Kabupaten Rokan Hilir. Analisis data dilakukan dengan metode IPA yang memperbandingkan antara persepsi perusahaan dan masyarakat. Komponen penyusun kuisioner untuk menilai persepsi terdiri atas penjabaran pernyataan yang diambil dari Peratutran Pemerintah no 47 tahun 2012 terkait pelaksanaan CSR dan beberapa literatur buku yang menjelaskan pelaksanaan CSR secara baik. Hasil penelitian ini menunjukkan bahwa kinerja implementasi kebijakan CSR yang telah dilaksanakan PT Perkebunan Nusantara V tergolong sangat baik dari aspek isi kebijakan dan dukungan, namun perlu perbaikan pada aspek transparansi, program CSR dan hasil.Transparansi dan keterbukaan informasi yang lebih luas menjadi poin penting untuk keterjangkauan terhadap sasaran pemberian CSR yang lebih baik untuk kedepannya.