bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantity of Relaxin Receptors in the Ligament of Head of Femur in Infants with Developmental Hip Dysplasia
Authors: Ayanoglu Semih , Çabuk Haluk , Çabuk Fatmagül Kuşku , Beng Kubilay , Yıldırım Timur , Bozkurt Süheyla Uyar 
Published: March 2021

Abstract
BackgroundDevelopmental dysplasia of hip (DDH) etiology is still a controversial issue. While many factors involved in the etiology, one of which is the hormone relaxin. Relaxin concentrations in patients with DDH may lead to pathodynamic changes during hip development by altering the physiological nature of the ligament, as well as by long-term exposure to relaxin during pregnancy. Our objective in this study was to determine the quantity of relaxin receptors in the ligamentum teres and their part in causing DDH.MethodsWe identified infants between birth and 3 years of age who had undergone open reduction for DDH between 2010 and 2012. 12 hips of 12 miss abortus fetus between 20 to 35 weeks of gestation were used as control group. Specimens obtained from two groups were stained with Relaxin-2 antibody and the amount of staining for relaxin receptors was determined using an ordinal H score. ResultsThe mean H scores of infants with DDH were significantly higher than those of controls (p=0.00). ConclusionAs a result, increased number of relaxin receptors in the ligamentum teres could be a risk factor for DDH and the number of relaxin receptors is an important clue in explaining the female:male ratio and clinical prognosis of early dysplastic hips.Level of Evidence: Level 2, Prospective comparative study
Solvothermal Synthesis of Bi2s3 Nanoparticles for Active Photocatalytic and Energy Storage Device Applications
Authors: Sambathkumar C. , Manirathinam V. , Manikandan A. , Kumar M. Krishna , Sudhakar S. , Devendran P. 
Published: March 2021

Abstract
High edge energy storage with large life-span stable materials have become the most significant and major requirement in near future. Bismuth sulfide (Bi2S3) Nanoparticles (NPs) was effectively synthesized by utilizing Bismuth diethyldithiocarbamate (Bi[DTC]) complex as single-source antecedent. The synthesized Bi2S3 NPs were affirmed by structural, morphological and thermal analysis with various analytical studies. The electrochemical performance of Bi2S3 NPs reveals that, exhibit redox behavior from cyclic voltammetry analysis, the charge-discharge analysis was examined by the galvanostatic chronopotentiometry. Bi2S3 NPs exhibit excellent supercapacitor behavior with value of the specific capacitance 470 Fg-1 at current density 0.5 Ag-1 and the retentivity of 79 % after 1000 cycles. The Bi2S3 NPs were further utilized as photocatalytic discoloration of Congo Red (CR) dye in aqueous medium under UV-light irradiation. Which shows, excellent catalytic behaviour, up to 98% of CR dye degrade within 150 min. and it is exhibit good catalytic stability and reusability.
Cardiac and Respiratory Arrest in a 12-Year-Old Girl with Acute Permethrin Toxicity: A Case Report
Authors: Atashi Hesam Adin , Arani Hamid Zaferani , Ghorani Seyyed Mojtaba , Khorasani Mahya Sadat Teimouri , Moalem Masoumeh 
Published: March 2021

Abstract
BackgroundPermethrin (PER) is widely employed as the most frequently used type I synthetic pyrethroid insecticide. Despite its worldwide application, reports of pediatric toxicity following permethrin administration are scarce.Case presentationThe present case report involves a 12-year-old Afghan girl, with no previous medical problems, who drank an unknown insecticide covertly at home. Two hours after ingestion, she was taken to the emergency room with neither breathing signs nor a heartbeat. She was immediately transferred to the cardiopulmonary resuscitation (CPR) room, and her spontaneous circulation was returned after a few minutes of CPR. She was then intubated, volume resuscitated with intravenous normal saline, and connected to the mechanical ventilator after being transferred to the ICU ward. The patient remained comatose without spontaneous breathing, her pupils became bilateral mydriasis, and central diabetes insipidus became evident after three days due to apnea and hypoxic brain damage following insecticide ingestion. The chemical analysis of the insecticide bottle showed 10% permethrin without organophosphates, as initially expected. Unfortunately, after seven days, the patient passed away due to resistant hypotension and severe brain damage.ConclusionPermethrin is widely used globally as an insecticide. However, there are many unmet needs in permethrin toxicity treatment, and the treatment is mainly supportive. Depending on the amount and dose of permethrin, the most common symptoms can vary from headache, dyspnea, and vomiting to metabolic acidosis and cardiac and respiratory arrest, which can lead to hypoxic brain damage and death, as was the outcome in our case.
Genetic Mapping Reveals Complex Architecture and Candidate Genes Involved in Common Bean Response to&nbsp;Meloidogyne Incognita&nbsp;Infection
Authors: Giordani Willian , Gama Henrique Castro , Chiorato Alisson Fernando , Marques João Paulo Rodrigues , Camargo Luis Eduardo Aranha , Huo Heqiang , Benchimol-Reis Luciana Lasry , Garcia Antonio Augusto Franco , Vieira Maria Lucia Carneiro 
Published: March 2021

Abstract
Root-knot nematodes (RKN), particularly Meloidogyne incognita, are among the most damaging and prevalent agricultural pathogens due to their ability to infect roots of almost all crop species, including common bean. The best strategy for their control is through the use of resistant cultivars. However, laborious phenotyping procedures make it difficult to assess nematode resistance in breeding programs. For common bean, this task is especially challenging since little has been done to discover resistance genes or find markers to assist selection. In this study, we performed genome-wide association studies and QTL mapping to explore the genetic architecture and genomic regions underlying the resistance to M. incognita and to identify candidate resistance genes. Phenotypic data were collected by a high-throughput assay, and the number of egg masses and root-galling index were evaluated 30 days after inoculation. Complex genetic architecture and independent genomic regions were associated with each trait according to the Fixed and random model Circulating Probability Unification. SNPs located on chromosomes Pv06, Pv07, Pv08 and Pv11 were associated with the number of egg masses, and on Pv01, Pv02, Pv05 and Pv10 with root-galling. A total of 215 candidate genes were identified, including 14 resistance gene analogs and five differentially expressed in a previous RNA-seq analysis. The histochemical analysis indicated that the reactive oxygen species might play a role in the resistance response. Our findings open new perspectives to improve selection efficiency for RKN resistance in common bean, and the candidate genes are valuable targets for functional investigation and gene editing approaches.
Raising Up Gender Equity Voices: Report from an International Virtual Assembly in Global Surgery
Authors: Campos Letícia Nunes , Pawlak Natalie , Velin Lotta , Ruzgar Nensi Melissa , Gerk Ayla , Reid Kevouy , Iraqi Habab Ali , Bentounsi Zineb , Drejza Michalina , Patil Dhrumil , Nassour Nour , Tatere Heaven Yeshaneh , Riaz Mehr Muhammad Adeel , Zakrison Tanya 
Published: March 2021

Abstract
Background: The adaptation of conferences to virtual platforms has allowed more international colleagues and underrepresented members of the surgical workforce to access educational opportunities. With the purpose of addressing the gap in open-access gender equity education, the Gender Equity Initiative in Global Surgery (GEIGS) held its first general assembly in 2020 as a pathway to promote capacity building on this topic.Objectives: This article aims to report the organization and outcomes of the GEIGS general assembly as an example of opportunities to develop capacity on gender equity and diversity in global surgery using virtual platforms. Project Design and Implementation: The GEIGS General Assembly was a two-day event held on December 12th and December 20th, 2020. The project was led by an organizing committee, composed of 11 individuals of diverse backgrounds, who were divided into logistics, advocacy, and sessions teams. The assembly planning was facilitated through weekly meetings under the supervision of the GEIGS steering committee.Main Achievements: GEIGS piloted a virtual global-scale general assembly that encompassed small-group and international community building, interactive learning, and advocacy. In terms of regional representation, there were 199 attendees from 46 different countries. The event highlighted the need to promote inclusion of non-English speakers in the global surgery community, and sessions about intersectionality; equity, social justice, and diversity; and national surgical, obstetric, and anesthesia planning garnered the most participant engagement. Moreover, social media engagement mirrored an increased utilization of online platforms for educational, advocacy and promotional purposes, enhancing both scholarly dissemination and capacity building. Policy Implications: Engaging in global surgery demands identifying leaders who will build awareness, workforce diversity, and capacity. Our report demonstrates that the topic of gender equity has not held a prominent place in global surgery, and that this first intersectional conference was an initial step to align both agendas and debate the role of female and non-binary health workers in surgical, anesthesia and obstetric specialties in an international, socially engaging, and region-specific context.
Effect of ferroelectric material activity on dielectric properties of ferroelectric-dielectric composite ceramics
Authors: Jin Jingjing , Xin Le , Shen Shiting , Li Zhengxin , Xue Yuze , Ren Luchao , Guo Xue , Chen Long , Zhai Jiwei , Zhang Mingwei 
Published: March 2021

Abstract
Ba0.6Sr0.4TiO3 ceramic doped with MgO was prepared by a conventional solid state reaction method. The effects of Ba0.6Sr0.4TiO3 pre-sintering at different temperatures on the phase composition, microstructure and microwave dielectric properties of composite ceramics were studied. The effect of different pre-sintering temperatures on composite ceramics is mainly reflected in different ion diffusion degree. The results show that the different pre-sintered ceramics have two crystal phases of perovskite structure Ba0.6Sr0.4TiO3 and cubic phase MgO. As the pre-sintering temperature increases, the dielectric permittivity of the composite ceramic decreases, and the grain size decreases obviously. When the pre-sintering temperature rises above 1200℃, the Curie peak of composite ceramic was strongly suppressed and broadened. The tunability at room temperature increases with the increase of the pre-sintering temperature of Ba0.6Sr0.4TiO3, which is due to the lower ion diffusion weakens Tc movement to low temperature. In addition, the loss tangent of the samples at room temperature was kept at a low level. When the pre-sintering temperature of Ba0.6Sr0.4TiO3 is 1250℃, the tunability is up to 29% (at 30 kV/cm), and the best Q value 132 (at 1.37GHz) was generated which is the most obvious improvement in dielectric properties compared to other pre-sintering temperature. This indicates that with the decrease of ion diffusivity, the properties of the ferroelectric-dielectric composite ceramics were significantly improved.
What Matters among Non-pharmaceutical Interventions on COVID-19 in Europe?
Authors: Yu Chuanhua , Liu Yan , Yu Qiuyan , Wen Haoyu , Shi Fang , Wang Fang , Zhao Yudi 
Published: March 2021

Abstract
Objectives

The purpose of this study is to describe the situation of the COVID-19 in European countries and identify important factors related to prevention and control.
Methods

We obtained data from World Health Statistics 2020 and the Institute for Health Metrics and Evaluation (IHME). We caculated the Rt values of 51countries in Europe under different prevention and control measures. We used lasso regression to screen factors associated with morbidity and mortality. For variables selected, we used quantile regression to analyze the relevant influencing factors in countries with different levels of morbidity or mortality.
Results

The government has a great influence on the change of Rt value through prevention and control measures. The most important factor for personal and group prevention and control is the mobility index, testing, the closure of educational facilities, restrictions on large-scale gatherings, and commercial restrictions. The number of ICU beds and doctors in medical resources are also key factors. Basic sanitation facilities, such as the proportion of safe drinking water, also have an impact on the COVID-19 epidemic.
Conclusions

This study describes the current status of COVID-19 in European countries. We found key factors in individual prevention and control measures and group prevention and control measures.
Absorbency of Biodegradable Materials for Menstrual Hygiene Management Products in Low-and Middle-income Countries
Authors: Foster Jasmin , Montgomery Paul 
Published: March 2021

Abstract
IntroductionGirls in low-and middle-income countries struggle to maintain good menstrual hygiene in part due to a lack of affordable sanitary products. The unaffordability of reliable sanitary products can lead to school absenteeism and is a barrier to education attainment and gender equality for girls in low income contexts. Further the lack of adequate disposal facilities can lead to social embarrassment and environmental pollution.MethodsLow-cost biodegradable absorbents (cotton terry cloth, linen, hemp cloth and bamboo wadding) were investigated in gelatine solution in terms of their absorptivity for use in menstrual hygiene.ResultsBamboo wadding exhibits the highest absorptivity index (7.86), greater than cotton terry cloth (0.84), hemp cloth (1.4), linen (1.57) and a commercial sanitary pad (4.38).ConclusionsThough the absorptivity index of bamboo wadding is promising, especially in the light of the vast availability of bamboo in tropical low-and middle income countries, challenges lie in overcoming complex extraction processes from bamboo plants which is discussed.
Covalently Engineered Nanobody Chimeras for Targeted Membrane Protein Degradation
Authors: Zhang Heng , Han Yu , Yang Yuanfan , Lin Feng , Lin Jian , Chen Peng 
Published: March 2021

Abstract
Targeted degradation of membrane proteins would afford an attractive and general strategy for treating various diseases that remain difficult with the current PROTAC methodology. We herein report a covalent nanobody-based PROTAC strategy, termed GlueTAC, for targeted membrane protein degradation with high specificity and efficiency. We first designed a MS-based screening platform for rapid development of covalent nanobody (Gluebody) that allowed proximity-enabled ligation with surface antigens on cancer cells. By conjugation with the cell-penetrating peptide and lysosomal-sorting sequence, the resulting GlueTAC chimera exhibited enhanced internalization with high efficacy and sustained eradication of tumor surface antigens such as PD-L1 and EGFR both in vitro and in vivo, which has broad applications in biomedical research and therapeutics.
An Offset Laser Measurement Method for the Deviation Analysis of Cylindrical Gear
Authors: Mei Ning , Song Aiping , Yu Chenwei , Pan Jianzhou 
Published: March 2021

Abstract

Generally, in the laser measurement of gears, the laser beam passes through the center of the gear, and the laser displacement sensor reads the spatial distance from the gear involute tooth surface to the laser displacement sensor. However, in this method, the angle between the laser beam and the normal vector of the measured tooth surface is too large, which affects the accuracy of the measurement and the stability of the data. This paper proposes an offset laser measurement method. The laser beam is offset from the center of the gear by a certain distance to form a larger incident angle with the tooth surface, which can effectively improve the problem and increase the measurement accuracy. Through the discussion of selecting the optimal offset distance, the range of optimal offset measurement position is obtained and clarified by experiments. We solved the data conversion problem caused by the change of measuring position, and measured the pitch deviation and helix angle of the gear to confirm the feasibility of this method. Based on theoretical calculation and experimental verification, it is found that this method has the advantages of better measurement accuracy and less measurement data fluctuations. It is suitable for precision gear measurement.
The Prevalence and Predictors of Fear of Childbirth Among Pregnant Chinese Women: a Hierarchical Regression Analysis
Authors: Huang Jingui , Huang Jing , Li Yan , Liao Bizhen 
Published: March 2021

Abstract
Background: Fear of childbirth(FOC) runs through before, during and after pregnancy, which is harmful to both the pregnant woman and fetus. To identify the prevalence and predictors of FOC can help us generate strategies for alleviating women’s FOC.Methods: A cross-sectional study was conducted among a convenience sample of 646 pregnant women attending antenatal care at a subordinate hospital of an university in China. Data were collected using a Basic information form, Childbirth Attitude Questionnaire, Childbirth Self-Efficacy Inventory, and 10-item Connor-Davidson Resilience Scale. We conducted hierarchical regression analysis to explore the predictors of FOC and used a structural equation model to examine the direct and indirect associations between FOC, resilience and childbirth self-efficacy further.Results: The average score on the Childbirth Attitude Questionnaire scale was 32.49 and the total prevalence of FOC was 67.1%. 45.4% women reported a mild level of fear, 19.5% reported moderate fear, and 2.2% reported a severe level of fear. The final regression analysis displayed six variables predicting FOC that explained 64.2% of variance in FOC: age (t=2.795, P<0.05), gestation age (t=2.566, P<0.05), parity (t=-5.191, P<0.01), spousal support (t=-6.119, P<0.01), resilience (t=-10.302, P<0.01) and childbirth self-efficacy (t=-16.435, P<0.01). Furthermore, childbirth self-efficacy mediated the relationship between FOC and resilience, and the mediation effect ratio was 53.5%.Conclusions: A high prevalence of FOC among pregnant Chinese women was found in this study. Age, gestation age, parity, spousal support, resilience and childbirth self-efficacy were predictors of FOC. It is suggested that the health-care professionals should pay close attention to FOC and take targeted interventions according to these predictors especially resilience and childbirth self-efficacy.
Prevalence of Hyperuricemia and the Relationship Between Serum Uric Acid Concentrations and Lipid Parameters Among King Abdulaziz University Hospital Patients
Authors: Ghamri Ranya A. , Qalai Tala A. , Ismail Raghad A. , Aljehani Joud M. , Alotaibi Dina S. , Aljahdali Maysam A. 
Published: March 2021

Abstract
Background: Hyperuricemia is a metabolic defect caused by high purine consumption, overproduction of uric acid, or reduced uric acid excretion. Hyperuricemia is the second most common metabolic disease after diabetes mellitus and can mediate proinflammatory endocrine imbalance in adipose tissue, which contributed to dyslipidemia. Furthermore, several studies have associated uric acid with dyslipidemia. However, no previous studies have examined patients without chronic illness. Thus, we aimed to assess the relationship between serum uric acid concentration and lipid profile parameters and to estimate the prevalence of hyperuricemia in the city of Jeddah. Methods: A retrospective study was conducted among 1206 patients without chronic illness after applying the exclusion criteria. Patients had undergone laboratory blood testing over a 3-year period (2018–2020) at King Abdulaziz University Hospital, which was ethically approved. We used a predesigned checklist to collect data from electronic hospital records using Google Forms. Bivariate analysis, tables, and graphs were used to represent and identify the relationships between variables. A P-value of <0.05 was considered significant.Results: Our study revealed a prevalence of 12% for hyperuricemia in the study population. Males were more frequently affected than females (8.13% vs. 3.73%, respectively). There was no association between serum uric acid concentration and lipid profile parameters, including total cholesterol (P = 0.92), triglyceride (P = 0.42), high-density lipoprotein (P = 0.47), and low-density lipoprotein (P = 0.66). There was a strong association between serum uric acid concentration and high body mass index (P < 0.001), older age (P = 0.002), male sex (P < 0.001), and nationality (P < 0.001). Furthermore, there was an association between sex and mean erythrocyte sedimentation rate (P = 0.02) and mean triglyceride concentration (P = 0.02).Conclusion: We observed a low prevalence of hyperuricemia, and our results indicate no association between serum uric acid concentration and lipid profile parameters.
HFLBSC: Heuristic and Fuzzy based Load Balanced, Scalable Clustering Algorithm for Wireless Sensor Network
Authors: Maratha Priti , Gupta Kapil 
Published: March 2021

Abstract
In spite of the severe limitations on the resources of the sensor nodes such as memory, computational power, transmission range and battery, the application areas of Wireless Sensor Networks (WSNs) are increasing day by day. The main challenge in WSNs is energy consumption. It becomes significant when a large number of nodes are deployed. Although clustering is one of the solutions to cater to this problem, but it suffers from severe energy consumption due to the non-uniform selection of CHs and frequent re-clustering. In this paper, we propose a heuristic and fuzzy based load balanced, scalable clustering algorithm for WSNs called HFLBSC. In this algorithm, we have segregated the network into a layered structure using the area under intersection over union curve. We have selected the CHs by considering residual energy and distance threshold. We have stalled the frequent re-clustering by utilizing the decision made with the help of fuzzy logic. Our proposed scheme is capable enough to elongate the network lifetime. Statistical analysis and simulation results confirm the superiority of proposed work in comparison to its competitor protocol.