bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Utility of Endoscopic Ultrasound-Guided Fine-Needle Aspiration Biopsy In Mixed Ductal-Neuroendocrine Neoplasms of The Pancreas
Authors: Wang pengyan , Wu Yan , Chen Jingci , Jiang Ying , Xue Xiaowei , Cheng Yuejuan , Wu Xi , Chang Xiaoyan 
Published: February 2021

Abstract
Background: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) biopsy is the first line diagnostic tool used in the evaluation of solid pancreatic masses with high sensitivity and specificity prior to the surgery. Mixed ductal-neuroendocrine neoplasms of the pancreas are rare entity consisting of both ductal adenocarcinoma and neuroendocrine neoplasms, with each component representing at least 30%. Methods: We performed a retrospective analysis of patients with a diagnosis of pancreatic mixed ductal adenocarcinoma and neuroendocrine neoplasms by EUS-FNA specimens at Peking Union Medical College Hospital between 2010-2019 and presented a review of the literature.Results: A total of 3 cases (1 male and 2 females) were evaluated, aged 46, 38 and 62 years, and presented with 3-cm, 2.3-cm and 1.8-cm pancreatic masses, respectively. All the patients presented with abdominal pain and underwent EUS-FNA biopsy. FNA smears revealed a mixture of ductal adenocarcinoma and neuroendocrine neoplasms, identified by immunohistochemistry. According to Ki-67 proliferation index and mitotic count, the tumor grades of the neuroendocrine component were classified as NET G2 in 2 cases (cases 2 and 3) and NEC in 1 (case 1). All of the patients received adjuvant therapy. The diagnosis of patient 1 was confirmed on surgical excision, and she died 5 months after surgery due to hepatic metastases. The other two patients did not undergo surgery, but achieved long – term survival of 3 and 5 years, respectively. To date, 34 cases of pancreatic mixed ductal adenocarcinoma and neuroendocrine neoplasms have been reported in the English language literature including our present three cases. Among them, 5 of 12 patients who underwent preoperative biopsy were diagnosed as combined ductal adenocarcinoma and neuroendocrine neoplasms, of which 3 surgical resection specimens available were identified as mixed ductal-neuroendocrine neoplasms.Conclusion: We suggest that EUS-FNA biopsy is the most effective method for rapid evaluation of pancreatic mixed ductal-neuroendocrine neoplasms with high sensitivity, which is important to determine the most optimum therapy. If the tumor grades of the neuroendocrine component were classified as NET G2 by EUS-FNA biopsy, we propose appropriate adjuvant therapy rather than surgery.
Kármán Vortex Street in an Immiscible Two-component Bose-Einstein Condensate
Authors: Li Xiao-Lin , Ren Xue-Ping , Wang Jing , Fan Xiao-Bei , Zhou Yu-Shan , Wan Xiao-Huan , Zhou Zhi-Kun , Meng Hong-Juan , Zhang Juan , Shi Yu-Ren 
Published: February 2021

Abstract
In this paper, we investigate a two-component Gross-Pitaevskii system with a moving obstacle potential, which describes the vortex shedding for an immiscible binary Bose-Einstein condensate composed of different hyperfine states of 87 Rb atoms. Numerical simulations indicate that, the Kármán vortex street is discovered in one component, while the Kármán-like vortex street named "ghost vortex street" is formed in the other. The other typical patterns of vortex shedding, such as vortex dipoles, V-shaped vortex pairs and corresponding "ghost vortex shedding", can also be found in the wake of obstacle. The instantaneous and time-averaged drag force acting on obstacle potential are calculated, which show the contribution to drag force from vortex shedding. The parameter region for various vortex patterns, critical velocity for vortex emission, and superfluid Reynolds number are presented and discussed. Finally, we provide an experimental protocol for the above realization and observation.
CD8+ Tregs Ameliorate Inflammatory Reactions in a Murine Model of Allergic Rhinitis
Authors: Lin Lin , Dai Fei , Wei Jinjin , Chen Zheng 
Published: February 2021

Abstract
Background
CD8+CD25+fork-head box transcription factor (Foxp3)+ regulatory T cells (CD8+ Tregs) play a role in immune tolerance. However, the role of these cells in allergic rhinitis (AR) has not been elucidated. The study aimed to evaluate influences of CD8+ Tregs on inflammatory conditions in a murine model of AR.
Methods
A murine model of AR was established. CD8+ Tregs were isolated from mice nasal mucosa and cultured in vitro. We examined interleukin (IL)-10 and transforming growth factor (TGF)-β in cell cultures. Then, we administered CD8+ Tregs into mice nasal mucosal cultures, and examined eosinophil cation protein (ECP), IL-4, IL-5 and IL-13 in these cultures. Finally, we adoptively transferred CD8+ Tregs into mice models, and evaluated percentages of CD8+ Tregs, numbers of sneezing and nasal rubbing, and counts of eosinophils and contents of ECP, IL-4, IL-5, IL-13, IL-10 and TGF-β in nasal lavage fluid (NLF) in mice.
Results
The percentage of CD8+ Tregs from AR mice was reduced. IL-10 and TGF-β were increased in cell cultures from AR mice. ECP, IL-4, IL-5 and IL-13 were decreased after the AR mice CD8+ Tregs administration in mucosal cultures. However, their contents were not changed after normal CD8+ Tregs treatment. Additionally, the adoptive transfer of AR CD8+ Tregs enhanced the percentage of CD8+ Tregs and levels of IL-10 and TGF-β in NLF, reduced numbers of sneezing and nasal rubbing, and counts of eosinophils and concentrations of ECP, IL-4, IL-5 and IL-13 in NLF. However, normal CD8+ Tregs could not change above parameters.
Conclusion
These findings show that CD8+ Tregs may inhibit inflammatory responses in the AR condition.
Development of 105 SNP markers in endangered turtle species Pelodiscus sinensis using RAD-seq
Authors: Xie Qiming , Liu Fan , Zhang Jilong , Li Xilei , Chen Tiantian , Fang Guoxia , Ma Rensheng , Su Shi-Ping 
Published: February 2021

Abstract
In this study, Restriction site-associated DNA sequencing (RAD-seq) was used to develop single-nucleotide polymorphism (SNP) markers for Pelodiscus sinensis, which is a commercially important species in China. We collected 15 individuals from Anhui Province and RAD-seq data of 20 individuals from NCBI: PRJNA530350 to screen high quality SNP maker through genome-wide. A total of 105 high-quality SNP markers were identified. The population genetic statistics showed that the minor allele frequency varied from 0.0571 to 0.3382, and the observed heterozygosity and expected heterozygosity ranged from 0.1143 to 0.6765 and 0.1078 to 0.4477, respectively. These novel SNP markers will serve as a valuable genetic tool for future conservation and population genetics studies in P. sinensis.
A Multifaceted Clinical Decision Support Intervention to Improve Adherence to Thromboprophylaxis Guidelines&nbsp;
Authors: Jaspers Tessa , Essenberg Marjolijn Duisenberg-van , Maat Barbara , Durian Marc , Berg Roy van den , Bemt Patricia van den 
Published: February 2021

Abstract
Background: Venous thromboembolism is a potentially fatal complication of hospitalisation, affecting approximately 3% of non-surgical patients. Administration of low molecular weight heparins to the appropriate patients adequately decreases venous thromboembolism incidence, but guideline adherence is notoriously low.Objective: To determine the effect of a multifaceted intervention on thromboprophylaxis guideline adherence. The secondary objective was to study the effect on guideline adherence specifically in patients with a high venous thromboembolism risk. As an exploratory objective, we determined how many venous thromboembolisms may be prevented.Setting: A Dutch general teaching hospital.Method: A prospective study with a pre- and post-intervention measurement was conducted. A multifaceted intervention, consisting of Clinical Decision Support software, a mobile phone application, monitoring of duplicate anticoagulants and training, was implemented. Guideline adherence was assessed by calculating the Padua prediction and Improve bleeding score for each patient. The number of preventable venous thromboembolisms was calculated using the incidences of venous thromboembolism in patients with and without adequate thromboprophylaxis and extrapolated to the annual number of admitted patients.Main outcome measure: Adherence to thromboprophylaxis guidelines in pre- and post-intervention measurements.Results: 170 patients were included: 85 in both control and intervention group. The intervention significantly increased guideline adherence from 49.4% to 82.4% (OR 4.78; 95%CI 2.37-9.63). Guideline adherence in the patient group with a high venous thromboembolism risk also increased significantly from 54.5% to 84.3% (OR 2.46; 95%CI 1.31-4.62), resulting in the potential prevention of ±261 venous thromboembolisms per year.Conclusions: Our multifaceted intervention significantly increased thromboprophylaxis guideline adherence.
Psychometric Properties of Medication Adherence Instruments in Cardiovascular Diseases and Type 2 Diabetes Mellitus: Systematic Review Protocol
Authors: Oliveira Henrique Ceretta , Neto Daisuke Hayashi , Carvalho Samantha Dalbosco Lins , de Barros Rita de Cássia Lopes , Neves Mayza Luzia dos Santos , Andrechuk Carla Renata Silva , Alexandre Neusa Maria Costa , Rodrigues Roberta Cunha Matheus 
Published: February 2021

Abstract
BackgroundThe pharmacological treatment of cardiovascular diseases and type 2 diabetes mellitus reduces the risk of cardiovascular events.; however, most patients do not adhere to the treatment. There are several self-reported measures for assessing medication adherence. Identifying the instruments with the best psychometric evidence is essential for selecting an accurate measure. The aim of this study is to critically assess, compare and synthesize the quality of the measurement properties of patient-reported outcome measures to access medication adherence among patients with cardiovascular diseases and/or type 2 diabetes mellitus.MethodsThis protocol is reported according to Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) and the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) guidelines. The following databases will be searched: Web of Science, SCOPUS, PubMed, CINAHL, EMBASE, LILACS, PsycINFO and ProQuest.DiscussionThis review will provide a detailed assessment of the measurement properties of self-reported medication adherence instruments in patients with cardiovascular diseases and/or type 2 diabetes mellitus to support clinical practice and research.Systematic review registrationPROSPERO CRD42019129109.
Effect of standard antibiotic prophylaxis versus enhanced prophylactic measures on rate of urinary tract infection after flexible ureteroscopy: A randomized clinical study
Authors: El-Agamy El-Sayed I. , Elhelaly. Mohamed A. , Abouelgreed Tamer A. , Abdrabuh Abdrabuh M. , Elebiary Mohamed F. , Abdelaal Mohamed A. 
Published: February 2021

Abstract
BackgroundPrevention of urinary tract infections (UTIs) after flexible ureteroscopy (fURS) remains controversial. The present study aimed to compare the rate of post-procedural UTI in patients subjected to the standard antibiotic prophylaxis alone versus enhanced prophylactic measures.Methodsfrom August 2018 to September 2020, a total of 100 patients subjected to fURS for management of ureteral and/or renal stones were included in this study. Patients were equally and randomly divided to two treatment groups using randomly computer-generated allocation tables and concealed envelope technique. Treatment groups included standard antibiotic prophylaxis group and enhanced prophylaxis group. Patients in the standard antibiotic prophylaxis group IV, fluoroquinolone 1 hour preoperatively and oral antibiotics were used for 24h postoperatively. In the enhanced prophylaxis group, patients had urine culture 10 days before the procedure. In addition to the antibiotic prophylaxis, hydrophilic-coated ureteral access sheaths were systematically used.ResultsComparison between the baseline and operative characteristics of the studied groups revealed no statistically significant differences. Postoperatively, 8 patients (16.0 %) in the standard prophylaxis group were diagnosed with UTI in comparison to 2 patients (4.0 %) in the enhanced prophylaxis group expressing a statistically significant difference (p = 0.046). Using binary logistic regression analysis, female patients’ sex [OR (95% CI): 0.09 (0.018–0.46), operative time [OR (95%CI): 0.97 (0.94–0.99)] were significant predictors of postoperative UTI in univariate analysis. However, only female sex remained significant in multivariate analysis [OR (95% CI): 0.09 (0.017–0.49)].ConclusionsUrinary tract infection after fURS can be significantly reduced by using the suggested enhanced prophylactic approach.
Targeting dysregulation signatures of p53-MDM2 interactions to identify newer small molecule inhibitors for cancer therapy: Insight from computational direction
Authors: Chukwuemeka Prosper Obed , Umar Haruna Isiyaku , Iwaloye Opeyemi , Oretade Oluwaseyi Matthew , Olowosoke Christopher Busayo , Elabiyi Michael Omoniyi , Igbe Festus Omotere , Oretade Oyeyemi Janet , Eigbe Joy Oseme , Adeojo Funmilayo Janet 
Published: February 2021

Abstract
Dysregulation of the p53-MDM2 interactions has been implicated in majority of human tumors presenting a target for finding small molecule inhibitors. In this study, a training set of 17 experimentally tested inhibitors of MDM2 was used to develop series of pharmacophore models among which a four-featured (AHRR_1) model with one hydrogen bond acceptor, one hydrophobic group and two aromatic ring features and characterized by a survival score of 4.176 was considered significant among the top ranked generated hypothesis. Further, the model was validated by an external set of actives and decoy molecules and was found to exhibit encouraging statistical attributes (such as AUC > 0.7, BEDROC > 0.5 and EF > 1.0 etc). The model was used to screen the ZINC compound database, from the database, the top best 1375 hits satisfying the pharmacophore model was were docked to MDM2 protein to identify the likely interactions of the compounds as well as their binding affinity with MDM2. Further, druglikeness and pharmacokinetic properties screening on top-ranked compounds with higher binding affinity than reference inhibitors revealed four compounds (ZINC02639178, ZINC38933175, ZINC77969611, and ZINC06752762) with suitable pharmacological properties including low ligand toxicity. Investigation of the dynamic behaviour of each candidate inhibitors in complex with MDM2 via molecular dynamic simulation suggested ZINC02639178 and ZINC06752762 as the most potential inhibitors. Thus, these compounds may emerged as therapeutic option for cancer treatment after extensive in vitro and in vivo studies.
The role of an international treaty in creating over time a sustainable network for interdisciplinary landscape approaches
Authors: Pătru-Stupariu Ileana , Nita Andreea 
Published: February 2021

Abstract
Context. The European Landscape Convention (ELC) of the Council of Europe represents the first international treaty that envisage all aspects when planning European landscapes. Through this convention, public authorities have been encouraged to adopt policies and measures at local, national and international level in order to protect, manage and properly plan landscapes in a sustainable manner. Objectives. Our study aims to provide a better understanding of the landscape governance research trends by using an innovative methodology to highlight ways to improve and optimize ELC implementation. Methods: For this, we analyzed published articles in international journals directly connected to ELC implementation between 2000 and 2020 (n=400). We use bibliometric indicators (i.e., publications, authors affiliations) and co-occurrence analysis with overlay visualization in time (i.e. keywords), in order to discover the landscape research trends and evolution in the past 20 years. Furthermore, we extracted 119 articles that we review considering for each article the assigned different attributes in order to perform a more detailed analysis of the ELC aspects covered in research. Results: The findings of our innovative analyses show the key player in promoting the European Landscape Convention principles in the research field, along with the evolution in time of the most common trends of ELC by identifying the perspectives of landscape conservation in the future.Conclusions. This paper provides insights for integrating novel technologies and innovative landscape approaches in the future and for the landscape sustainability.
Photosynthetic parameters and growth of rice, lettuce, sunflower and tomato in an Entisol as affected by soil acidity and bioaccumulation of Ba, Cd, Cu, Ni and Zn
Authors: Rabêlo Flávio Henrique Silveira , Lavres José , Pinto Flávio , Alleoni Luís 
Published: February 2021

Abstract
The bioaccumulation of trace elements (TEs) in crops consumed by humans can lead to a lower food production due to photosynthetic damages and several diseases in humans, but decreasing soil acidity could mitigate these problems by decreasing TEs bioavailability. Thus, we evaluate the effect of increasing soil base saturation (BS%) on photosynthesis, growth and bioaccumulation of barium (Ba), cadmium (Cd), copper (Cu), nickel (Ni) or zinc (Zn) in lettuce (Lactuca sativa L.), rice (Oryza sativa L.), sunflower (Helianthus annuus L.) and tomato (Solanum lycopersicum L.) grown in sandy Entisol. The crops were grown in uncontaminated or contaminated Entisol, under two BS% ratios: 30% for all crops or 50% for rice and 70% for lettuce, sunflower and tomato. The photosynthesis-related parameters varied depending on the metal and crop, but in general, increasing BS% did not attenuate photosynthetic damages induced by Ba, Cd, Cu, Ni and Zn in the crops. There was no strong correlation between the photosynthetic parameters measured and biomass production, which suggest us that the suppression on biomass induced by Ba, Cd, Cu, Ni or Zn is related to other metabolic disorders besides the impairment on CO2 assimilation or chlorophyll synthesis in the crops assayed, with exception of Ni and Zn in lettuce. In conclusion, increasing BS% was not consistent in decreasing Ba, Cd, Cu, Ni and Zn accumulation in the edible parts of lettuce, rice, sunflower and tomato grown in the sandy soil, which probably is related to the low capacity of this soil in control TEs bioavailability.
Fabrication of graphene: CdSe quantum dots/CdS nanorod heterojunction photodetector and role of graphene to enhance the photoresponsive characteristics
Authors: Veeramalai Chandrasekar Perumal , kollu Pratap , Lin Guochen , Zhang Xiaoming , Li Chuanbo 
Published: February 2021

Abstract
Integration of graphene with semiconducting quantum dots (QDs) provides an elegant way to access the intrinsic properties of graphene and optical properties of QDs in a single hand to realize the high-performance optoelectronic devices. In the present study, high-performance photodetector based on graphene: CdSe QDs/CdS nanorod heterostructures, are demonstrated. The resulting heterojunction photodetector with device configuration ITO/graphene: CdSe/CdS nanorods/Ag show excellent operating characteristics including a maximum photoresponsivity of 15.95 AW-1 and specific detectivity of 6.85×1012 Jones measured at 530 nm. The device exhibits a photoresponse rise time of 545 ms and a decay time of 539 ms. Furthermore, the effect of graphene nanosheets on the performance enhancement of heterojunction photodetector was explored. The results indicate that, due to the enhanced energy transfer from photoexcited QDs to graphene layer, light absorption is increased and excitons are generated. Also, the graphene: CdSe QDs/CdS nanorod interface can facilitate charge carrier transport effectively. This work provides a promising approach to develop high-performance visible-light photodetectors and utilization of advantageous features of graphene in optoelectronic devices.
Episode Four: Khairani Barokka
Authors: Shah Rajni , Barokka Khairani , 周 Gibbons Fili 
Published: February 2021

In this short conversation Rajni Shah and Kharaini Barokka (Okka) discuss the complex relationships between listening, safety, harm, accountability, and trust. These topics are especially poignant because Okka and Rajni did not know each other before recording this podcast, and so we hear them navigating in their own conversation some of the questions they are reflecting on together.
In the accompanying offering, Okka shares some of her daily wellbeing practices.
Full credits and transcript for this episode will be published when the episode is released on 12 April 2021.
Synergistic Extraction of Europium (III) using Di-n-Butylsulfoxide and
Picrolonic Acid
Authors: Menaa Farid , Rehman Wajid , Fazil Srosh , Liaqat Khurram , Khan Muhammad Haleem , Khan Mohammad Mansoob , Siraj ul Haq  , Sajid Muhammad , Farooq Muhammad , Menaa Bouzid , Hafeez Muhammad 
Published: February 2021

Aim and Objective:
Europium (Eu(III))isa rare-earth metal, the softest, least dense, and most volatile member of lanthanides. It is greatly applied in control rods of nuclear reactors. Although various extraction methods of Eu(III)have been reported, we present a novel mixture ofeasily available extractants in optimizedexperimental conditions to extract it efficiently, quickly, and cost-effectively.

Materials and Methods:
Physical-chemical conditions (e.g. pH, equilibration time, temperature, europium concentration, extractants concentration, presence of specific metal ions) were optimized. The extractantspicrolonic acid (HPA) and di-n-butylsulfoxide (DBSO) were thoroughly mixed at equal concentrationin chloroform. Standard Eu(III) solution was used for method accuracy.Reagent blank was prepared under identical conditions but without metal ions.Using the metallochromic dye arsenazoIII as blank, absorbance of Eu(III) was measured spectrophotometricallyat 651 nm. Distribution ratio (i.e.Eu(III) concentration in aqueous phase before and after extraction) defined the extraction yield.

Results:
HPA/DBSO mixture (0.01 M)had a synergistic effect on Eu(III) extraction (1.19×10-5 mole/dm3) achieving a maximum yield (≥99%) at pH2, during 5 minutes equilibration,atroom temperature.Eu(III) extraction was reduced depending on the nature but not on the metal ions concentration. Extractants could be recycled four times without consequent degradation. Deionized water (dH2O) was the best strippantbesides its availability and low-cost. The composition of the extracted adduct was defined as Eu(PA)3.2DBSO.

Conclusion:
This alternative method was stable, simple, rapid, cost-effective, reliable, accurate and sensitive.It could be used forEu(III) extraction and refining on a pilot plant scale.