bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seroprevalence of anti-SARS-CoV-2 antibodies in Japanese COVID-19 patients
Authors: Hiki Makoto , Tabe Yoko , Ai Tomohiko , Matsue Yuya , Harada Norihiro , Sugimoto Kiichi , Matsushita Yasushi , Matsushita Masakazu , Wakita Mitsuru , Misawa Shigeki , Idei Mayumi , Miida Takashi , Tamura Naoto , Takahashi Kazuhisa , Naito Toshio 
Published: April 2021

Objectives
To determine the seroprevalence of anti-SARS-CoV-2 IgG and IgM antibodies in symptomatic Japanese COVID-19 patients.

Methods
Serum samples (n = 114) from 34 COVID-19 patients with mild to critical clinical manifestations were examined. The presence and titers of IgG antibody for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were determined by a chemiluminescent microparticle immunoassay (CMIA) using Alinity i SARS-CoV-2 IgG and by an immunochromatographic (IC) IgM/IgG antibody assay using the Anti-SARS-CoV-2 Rapid Test.

Results
IgG was detected by the CMIA in 40%, 88%, and 100% of samples collected within 1 week, 1–2 weeks, and 2 weeks after symptom onset in severe and critical cases, and 0%, 38%, and 100% in mild/moderate cases, respectively. In severe and critical cases, the positive IgG detection rate with the IC assay was 60% within one week and 63% between one and two weeks. In mild/moderate cases, the positive IgG rate was 17% within one week and 63% between one and two weeks; IgM was positive in 80% and 75% of severe and critical cases, and 42% and 88% of mild/moderate cases, respectively. On the CMIA, no anti-SARS-CoV-2 IgG antibodies were detected in COVID-19 outpatients with mild symptoms within 10 days from onset, whereas 50% of samples from severe inpatients were IgG-positive in the same period. The IC assay detected higher IgM positivity earlier from symptom onset in severe and critical cases than in mild/moderate cases.

Conclusions
A serologic anti-SARS-CoV-2 antibody analysis can complement PCR for diagnosing COVID-19 14 days after symptom onset.
Assessing required SARS-CoV-2 blanket testing rates for possible control of the outbreak in the epicentre Lusaka province of Zambia with consideration for asymptomatic individuals: A simple mathematical modelling study
Authors: Sichone Joseph , Sinkala Musalula , Munsaka Sody , Kikonko Mervis , Simuunza Martin 
Published: April 2021

Introduction
The novel Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus—2 (SARS-CoV-2), in Africa is characterised by a more substantial proportion of asymptomatic (or mildly symptomatic) individuals thought to be playing a role in the spread of the infection. The exact proportion and degree of infectiousness of asymptomatic individuals remains unclear. Studies however indicate that their management is crucial for control of SARS-CoV-2 transmission.

Methodology
We developed a simplified deterministic susceptible-exposed-infectious-removed (SEIR) mathematical model to assess the effect of active isolation of SARS-CoV-2 infected but asymptomatic individuals through blanket testing for control of the outbreak in Lusaka Province of Zambia. Here we modelled two scenarios; (1) assuming asymptomatic individuals comprised 70% of all COVID-19 cases and (2) asymptomatic individuals comprised only 50% of the cases. For contrast, the model was assessed first under the assumption that asymptomatic individuals are equally as infectious as symptomatic individuals and then secondly, and more likely, assuming asymptomatic individuals are only half as infectious as symptomatic individuals.

Results
For the model assuming 70% asymptomatic cases, a minimum sustained daily blanket testing rate of ≥ 7911 tests/100000 population was sufficient to control the outbreak if asymptomatic individuals are only half as infectious while if equal infectiousness was assumed then a testing rate of ≥ 10028 tests/ 100000 population would be required. For 50% asymptomatic, minimum blanket testing rates of ≥ 4540 tests/ 100000 population was sufficient to control the outbreak at both assumed levels of infectiousness for asymptomatic individuals relative to symptomatic individuals.

Discussion and conclusion
Our model predicts that active isolation of COVID-19 cases, including asymptomatic individuals, through blanket testing can be used as a possible measure for the control of the SARS-Cov-2 transmission in Lusaka, Zambia, but it would come at a high cost.
Analysis in silico of the single nucleotide polymorphism G–152A in the promoter of the angiotensinogen gene of Indonesian patients with essential hypertension
Authors: Susanto Akhiyan Hadi , Widodo  , Rohman Mohammad Saifur , Utomo Didik Huswo , Lukitasari Mifetika 
Published: April 2021

Abstract

Background
Single nucleotide polymorphism (SNP) G–152A (rs11568020) in the promoter of the angiotensinogen gene (AGT) may modulate its transcription. Translation of mRNA to angiotensinogen induces hypertension during hypoxia. The G allele at position –152 is located within the hypoxia-response element (HRE) transcription factor-binding site for the hypoxia-inducible factor 1 (HIF-1) heterodimer. However, the function of the –152 site in HIF-1 binding is not fully elucidated.

Objectives
To determine the frequency of SNP G–152A in Indonesian patients with hypertension and the function of this SNP.

Methods
We determined the frequency of the SNP in 100 patients by direct sequencing, and the influence of SNP G–152A on predicted binding of HIF-1 to the HRE using a docking approach in silico.

Results
The AGT promoter in our patients had genetic variants –152G and –152A (19:1). Predicted binding indicated that HIF-1 directly contacts the major groove of the G allele, but not the A allele. Scoring according to weighted sum High Ambiguity Driven biomolecular DOCKing showed that the score for the A allele–HIF-1 complex (–47.1 ± 6.9 kcal/mol) was higher than that for the G allele–HIF-1 complex (–94.6 ± 14.1 kcal/mol), indicating more favorable binding of HIF-1 to the G allele.

Conclusions
SNP G–152A reduces the favorability of binding of HIF-1 to the HRE. The occurrence of this SNP in the AGT promoter of Indonesian patients with essential hypertension suggests that the G allele is a genetic susceptibility factor in hypertension regulated by HIF-1.
Methods of Test for Concrete Permeability: A Critical Review
Authors: Milla Jose , Cavalline Tara L. , Rupnow Tyson D. , Melugiri-Shankaramurthy Bharath , Lomboy Gilson , Wang Kejin 
Published: April 2021

Abstract
The transport of liquids, gasses, and aggressive agents into concrete is responsible for a variety of durability issues. To obtain the low-permeability concrete required for long-lasting, sustainable infrastructure, stakeholders desire the ability to specify concrete based upon the permeability rating for specific uses. The mechanisms of moisture ingress into concrete are complex phenomena, and they are highly dependent on materials, mixture characteristics, curing conditions, and other factors. This review article provides an overview of the available permeability test methods and identifies existing gaps in the current field and knowledge. It discusses the mechanisms and key factors influencing moisture movement within concrete (capillary suction, absorption, water, and gas permeability) and outlines the procedures, advantages, and limitations of available permeability test methods. Despite a variety of tests available for water permeability, widespread acceptance for use of a single (or even a few) tests has not been achieved. No clear link exists between these tests and acceptable field performance. Additionally, several tests are viewed as problematic from a time, cost, or variability standpoint. Therefore, improved rapid permeability tests are needed to provide a pathway for agencies to move toward performance specifications with confidence. Recommendations regarding future work to support the development of improved test methods and, potentially, a model that would predict moisture ingress based on electrical resistivity, are also presented.
A Nondestructive Longitudinal Laboratory Test Method for Detection of Incipient Ultrastructural Changes in Wood
Authors: Lepage Robert , Glass Samuel V. , de la Bastide Paul Y. , Mukhopadhyaya Phalguni 
Published: April 2021

Abstract
The established methods for determining the effects of ultrastructural changes in structural wood members rely upon traditional, possibly outmoded, testing paradigms. These methods usually involve destructive testing of wood specimens that are exposed to environmental conditions infrequently experienced in buildings. Understanding how the ultrastructure changes with time within the same specimen is crucial for building practitioners in assessing risks to life-safety, assessing remaining service life of structural components, and aiding in the identification of mitigation or remediation measures. The primary agents causing ultrastructural modifications to wood are wood rotting basidiomycetes but may also include other biotic and abiotic agents; the methods contained herein should be applicable to all such longitudinal experiments. This article reviews existing literature on decay testing and validates a new method to assess longitudinal changes in mechanical properties with time using nondestructive test measures at relevant moisture contents. The validation testing shows this method has a good degree of repeatability and should permit the initial detection and monitoring of ultrastructure changes (e.g., decay). The method uses a repeatable, nondestructive four-point testing procedure for specimens controlled to specific moisture contents using energy dissipation as the salient performance metric. Recommendations are provided to refine this novel test method.
INFLUENCE OF DIGITAL IMAGES PRELIMINARY NOISING ON STATISTICAL STEGDETECTORS PERFORMANCE
Authors: Progonov D. O. 
Published: April 2021

Context. The problem of sensitive information protection during data transmission in communication systems was considered. The case of reliable detection of stego images formed according to advanced embedding methods was investigated. The object of research is digital images steganalysis of adaptive steganographic methods.
Objective. The goal of the work is performance analysis of statistical stegdetectors for adaptive embedding methods in case of preliminary noising of analyzed image with thermal and shot noises.
Method. The image pre-processing (calibration) method was proposed for improving stego-to-cover ratio for state-of-the-art adaptive embedding methods HUGO, MG and MiPOD. The method is aimed at amplifying negligible changes of cover image caused by message hiding with usage of Gaussian and Poisson noises. The former one is related to influence the thermal noise of chargecoupled device (CCD) based image sensor during data acquisition. The latter one is related to shot noise that originates from stochastic process of electron emission by photons hitting of CCD elements. During the research, parameters of thermal noise were estimated with two-dimensional Wiener filter, while sliding window of size 5·5 pixels was used for parameters evaluation for shot noise.
Results. The dependencies of detection error on cover image payload for advance HUGO, MG and MiPOD embedding methods were obtained. The results were presented for the case of image pre-noising with both Gaussian and Poisson noises, and varying of feature pre-processing methods.
Conclusions. The conducted experiments confirmed effectiveness of proposed approach for image calibration with Poisson noise. Obtained results allow us to recommend linearly transformed features to be used for improving stegdetector performance by natural image processing. The prospects for further research may include investigation usage of special noises, such as fractal noises, for improving stego-to-cover ratio for advanced embedding methods.
Koszt społeczny w rachunkowości
Authors: Kuberska Ewelina 
Published: April 2021

Objective: To present the role of accounting from the point of view of the development of accounting in sustainable development and to propose a definition of externalities in accounting.Research Design & Methods: An analysis of the subject literature was conducted and coupled with logical deduction.Findings: The role of accounting in sustainable development is in providing information about the influence a company’s activities have on the environment and society. This role arises from the existence of several factors, including social responsibility in accounting, the theory of legitimacy in accounting, the concept of full cost accounting, and the directive on the disclosure of non-financial information.Implications / Recommendations: It is important today to begin tracking external costs more precisely in accounting, to treat them as a new area of research and to carry on the research and studies connected with measuring and evaluating social costs and include them in the company’s financial performance.Contribution: Observing externalities in accounting and including them could help strengthen the scope of research areas in accounting for sustainable reporting and complete the definition of cost in accounting, which is behind the curve due to the growing trend of sustainable development.
The effect of off-axis seating on the marginal adaptation of full coverage all ceramic crowns
Authors: Babiolakis George P , Owen C Peter 
Published: April 2021

INTRODUCTION: No studies on the marginal gap or internal fit of crowns have reported the effect of non-axial seating which may often occur inadvertently clinically. AIM: Therefore this in vitro study sought to investigate the off-axis seating of CAD/CAM crowns and its effect on the marginal gap and internal fit. METHOD: A standardised crown preparation on a typodont tooth was used to design and mill 30 crowns with a flat occlusal surface. Ten Zirconia (Dentsply Sirona, Germany), 10 Enamic (Vita, Austria), and 10 Brilliant Crios (Coltene, Switzerland) crowns were milled, Ave of each milled with a luting space of 100µm, and Ave of 200µm. The marginal gap was measured in two and three dimensions after luting with silicone on a 3D-printed metal replica. Seating occurred axially, at 5° buccally and 5° lingually. The silicone was used to calculate the internal fit RESULTS: Axial seating with a 100 µm luting space obtained the smallest marginal gap, irrespective of material or luting space. 3D measurements were larger than 2D measurements, but not significantly. The maximum off-axis gap was 117µm, on the opposite side to which pressure was applied. CONCLUSIONS: Care must be taken clinically to ensure that luting takes place in an axial direction only.
Preparing for menarche: treatment and management of heavy periods in women with bleeding disorders
Authors: Lavin Michelle , Kadir Rezan A , Mackensen Sylvia von , Pollard Debra , Tollwé Anna 
Published: April 2021

Abstract
Prolonged menstrual bleeding interferes with daily life and causes marked blood loss, resulting in anaemia and fatigue. Treatment centres should address the issue of heavy menstrual bleeding (HMB) with pre-pubertal girls in advance of their first period, in order to best prepare them. It is common for a bleeding disorder to be overlooked in primary care and in gynaecology clinics, and women sometimes struggle to get a correct diagnosis. There are cultural taboos that inhibit open discussion of menstruation, and women tend to minimise the severity of their symptoms. Health professionals should work to destigmatise the issue and seek an accurate account of bleeding severity, with diagnosis and treatment provided in a joint clinic combining gynaecology and haematology expertise. Treatment should be individualised, taking into account personal, social and medical factors, with the aim of improving quality of life. Great care is needed with regard to choice of language when talking about treatment, and treatment centres should consider offering open access to women who need support in dealing with adverse effects. National member organisations have an important role to play in educating people with bleeding disorders, health professionals and the wider public about the burden of HMB associated with bleeding disorders.
El proceso de virtualización forzoso del sistema universitario. Luces y sombras detrás de la pandemia
Authors: Iriarte Alicia , Cravino Ana , Rango Marina , Juan Roldán Juan Roldán , Mombrú Ruggiero Andrés 
Published: April 2021

El presente artículo se enmarca en el proyecto de investigación UBACyT (2018/2020) Transformaciones de los Sistemas universitarios en América Latina: Su adecuación a las tendencias del nuevo escenario internacional y la globalización. Recientes estrategias y modalidades de la virtualización de la educación superior, y sus objetivos se centraron en indagar sobre el impacto de la virtualización forzosa de la enseñanza sobre la comunidad educativa. Para ello se realizaron, en primera instancia, más de quinientas encuestas a estudiantes universitarios y del último año de la escuela media y a docentes de grado y posgrado, y posteriormente entrevistas en profundidad a profesores universitarios, todos ellos involucrados en este proceso de virtualización. Presentamos aquí los resultados del primer relevamiento de información acerca de la forma en que docentes y estudiantes universitarios experimentaron las modificaciones que se produjeron a raíz del traslado de la cursada presencial a la virtualidad en 2020. Queríamos conocer sus opiniones y ver qué temas adquirían centralidad y quedan planteados para el debate. La información obtenida nos permitió obtener un panorama de la presente situación educativa tomando como recurso las creencias y percepciones de los actores involucrados.
Evaluating the quality of educational services from the perspective of learners at Mashhad University of Medical Sciences in 2018
Authors: Jahantab Zahra , Yousefi Masoud , MohammadHoseinzadeh Masoume , Khadem-Rezaiyan Majid 
Published: April 2021

Introduction: Students are the main recipients of educational services in universities. By investigating their expectations and perceptions of educational performance, we can provide the context for program developing to improve educational quality of services. In previous studies, the quality of services was reported from the perspective of undergraduate students. Since the expectations and the type of education are various in different stages, the current study investigates the quality of educational services based on the SERVQUAL model in postgraduate and graduate students.
Methods: This cross-sectional study was conducted on 321 students at Mashhad University of Medical Sciences (58 bachelor, 67 masters, 58 PhD and 134 residents) by a questionnaire to evaluate the quality of educational services based on SERVQUAL model in 2018. Participants were selected by convenient sampling method and by answering the questionnaire, their opinions in five dimensions of service quality (Reliability, Responsiveness, Empathy, Assurance, Tangibles with a score range from 1 to 4 and the gap between the current situation and the desired between -3 to +3) were determined. Data analysis was performed using SPSS software version 26, paired t-test, independent sample t-test and ANOVA.
Result: The results of current study indicated that there was a negative gap between students' expectations and perceptions in all five dimensions. ). In general, the largest gap was in the response dimension (-1.1 ± 0.76) and the lowest was in the confidence dimension (-0.78 ± 0.69). Among different levels of students, the largest gap is from the perspective of undergraduate students (-1.1 ± 0.7) and the smallest gap possess to the PhD students (-0.69 ± 0.57), and the total service gap from the viewpoint of the non-native students (-1.0 ± 0.6) was higher than native students (-0.85 ± 0.67).
Conclusion: According to this study, the quality of services has been lower than students' achievements in all dimensions. This requires specific planning in priority areas for quality improvement.
Designing a mentoring model to enhance the human capital of faculty members in medical universities
Authors: Keykha Ahmad 
Published: April 2021

Introduction: The purpose of present study was to analyze the content of domestic and foreign articles in the field of mentoring faculty members to provide a model for promoting the human capital of faculty members in medical universities.
Methods: This research has been compiled by a synthesis research review (Meta-synthesis strategy). Therefore, after designing the research questions (what are the main components of the faculty mentoring model? What are the factors influencing the faculty mentoring model? What are the main characteristics of mentoring and mentoring faculty members? What are the faculty mentoring challenges? Systematic search of articles in time period (1390-1399) (2000-2020) in Persian and English in Magiran databases, SID; Human, Noormags, ScienceDirect, Eric, Sage with the keywords of "Mentoring Faculty Members" and "Mentoring in Higher Education". Consequently, out of 73 researches, 38 researches acquired the final analysis.
Result: Findings in response to the first question, with 5 sub-categories (regular prior planning, preparation, correct implementation, systematic feedback and results management), in response to the second question, in 3 sub-categories (incentive capacity development, effective cooperation, interests and expectations) Mentor and Menti), in response to the third question, with 3 secondary sub-categories (Menti personality traits, Menti specialized traits and Menti cognitive traits) and Mentor faculty members, including 5 traits (Mentor personality traits, Mentor specialized traits, counseling services, empowerment research and educational empowerment) were classified. In response to the fourth question, they were categorized into 6 sub-categories (inappropriate interactions, weak mental performance, weak mental performance, unfamiliarity with academic norms, inefficient management, lack of planning).
Conclusion: Considering the importance of Mentoring programs in the development of human capital of faculty members of medical universities, the identified components should be considered by the managers of the higher education system to improve the performance of faculty members.