bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting ACLY Attenuates Tumor Growth and Acquired Cisplatin Resistance in Ovarian Cancer by Inhibiting the PI3K–AKT Pathway and Activating the AMPK–ROS Pathway
Authors: Wei Xuan , Shi Juanjuan , Lin Qianhan , Ma Xiaoxue , Pang Yingxin , Mao Hongluan , Li Rui , Lu Wei , Wang Yu , Liu Peishu 
Published: March 2021

Background: Ovarian cancer is the most lethal female genital malignancy. Although cisplatin is the first-line chemotherapy to treat ovarian cancer patients along with debulking surgeries, its efficacy is limited due to the high incidence of cisplatin resistance. ATP citrate lyase (ACLY) has been shown to be a key metabolic enzyme and is associated with poor prognosis in various cancers, including ovarian cancer. Nevertheless, no studies have probed the mechanistic relationship between ACLY and cisplatin resistance.Methods: Survival analysis was mainly carried out online. Bioinformatic analysis was performed in R/R studio. Proliferative activity was measured by MTT and colony formation assays. Cell cycle and apoptosis analysis were performed by flow cytometry. The acquired-cisplatin-resistant cell line A2780/CDDP was generated by exposing A2780 to cisplatin at gradually elevated concentrations. MTT assay was used to calculate IC50 values of cisplatin. A xenograft tumor assay was used test cell proliferation in vivo.Results: Higher expression of ACLY was found in ovarian cancer tissue and related to poor prognosis. Knockdown of ACLY in A2780, SKOV3, and HEY cells inhibited cell proliferation, caused cell-cycle arrest by modulating the P16–CDK4–CCND1 pathway, and induced apoptosis probably by inhibiting p-AKT activity. Bioinformatic analysis of the GSE15709 dataset revealed upregulation of ACLY and activation of PI3K–AKT pathway in cells with acquired cisplatin resistance, in line with observations on A2780/CDDP cells that we generated. Knockdown of ACLY alleviated cisplatin resistance, and works synergistically with cisplatin treatment to induce apoptosis in A2780/CDDP cells by inhibiting the PI3K–AKT pathway and activating AMPK–ROS pathway. The ACLY-specific inhibitor SB-204990 showed the same effect. In A2780/CDDP cells, AKT overexpression could attenuate cisplatin re-sensitization caused by ACLY knockdown.Conclusions: Knockdown of ACLY attenuated cisplatin resistance by inhibiting the PI3K–AKT pathway and activating the AMPK–ROS pathway. These findings suggest that a combination of ACLY inhibition and cisplatin might be an effective strategy for overcoming cisplatin resistance in ovarian cancer.
Effects of Mental Fatigue in Total Running Distance and Tactical Behavior During Small-Sided Games: A Systematic Review With a Meta-Analysis in Youth and Young Adult's Soccer Players
Authors: Clemente Filipe Manuel , Ramirez-Campillo Rodrigo , Castillo Daniel , Raya-González Javier , Silva Ana Filipa , Afonso José , Sarmento Hugo , Rosemann Thomas , Knechtle Beat 
Published: March 2021

Background: Mental fatigue can impact physical demands and tactical behavior in sport-related contexts. Small-sided games (SSGs) are often used to develop a specific sport-related context. However, the effects of mental fatigue on physical demands and tactical behaviors during soccer SSGs have not been aggregated for systematical assessment.Objective: This systematic review (with a meta-analysis) was conducted to compare the effects of mental fatigue vs. control conditions in terms of the total running distance and tactical behavior of soccer players during SSGs.Methods: The data sources utilized were PubMed, PsycINFO, Scielo, Scopus, SPORTDiscus, and Web of Science. The study eligibility criteria were established based on PICOS: (i) Population: healthy youth and young adult men soccer players with regular training practice and belonging to teams with regular competitions; (ii) Intervention: exposed to mental fatigue-induced protocols only before SSGs; (iii) Comparator: control conditions (passive or active not promoting mental fatigue) before SSGs; (iv) Outcomes: physical demands (total running distance) and tactical behavior (attacking behavior accuracy, pass decision-making accuracy, and space exploration index); (v) Study design: counterbalanced cross-over design; and (vi) only full-text and original articles written in English.Results: The database search initially identified 111 titles. From those, six articles were eligible for the systematic review and meta-analysis. Results showed no significant effect of fatigue on total running distance (ES = 0.13; p = 0.307) and tactical behavior (ES = 0.56; p = 0.079).Conclusions: A non-significant effect of mental fatigue on total running distance and tactical behaviors performed by soccer players during SSGs was found in this systematic review.
Field Test of a Passive Infrared Camera for Measuring Trail-Based Physical Activity
Authors: Abildso Christiaan G. , Haas Vaike , Daily Shay M. , Bias Thomas K. 
Published: March 2021

Introduction: Trails are ubiquitous and far-reaching, but research on the impact trails have on physical activity is limited by the lack of resource-efficient, accurate, and practical systematic observation tools. Commonly used infrared trail sensors count trail use and may broadly differentiate activity (i.e., bicyclist vs. pedestrian), but cannot detect nuances needed for outcomes research such as frequency, intensity, time, and type of activity. Motion-activated passive infrared cameras (PICs), used in ecological research and visitor management in wildlife areas, have potential applicability as a systematic observation data collection tool.Materials and Methods: We conducted a 7-month field test of a PIC as a systematic observation data collection tool on a hiking trail, using photos to identify each trail user's physical activity type, age, sex, and other characteristics. We also tallied hourly trail use counts from the photos, using Bland–Altman plots, paired t-tests, Concordance Correlation Coefficient, Kendall's Tau-b, and a novel inter-counter reliability measure to test concordance against concurrent hourly counts from an infrared sensor.Results: The field test proved informative, providing photos of 2,447 human users of the trail over 4,974 h of data collection. Nearly all of the users were walkers (94.0%) and most were male (69.2%). More of the males used the trail alone (44.8%) than did females (29.8%). Concordance was strong between instruments (p &lt; 0.01), though biased (p &lt; 0.01). Inter-counter reliability was 91.1% during the field study, but only 36.2% when excluding the hours with no detectable trail use on either device. Bland–Altman plots highlighted the tendency for the infrared sensor to provide higher counts, especially for the subsample of hours that had counts &gt;0 on either device (14.0%; 694 h).Discussion: The study's findings highlight the benefits of using PICs to track trail user characteristics despite the needs to further refine best practices for image coding, camera location, and settings. More widespread field use is limited by the extensive amount of time required to code photos and the need to validate the PICs as a trail use counter. The future potential of PICs as a trail-specific PA research and management tool is discussed.
Building Damage Detection Based on OPCE Matching Algorithm Using a Single Post-Event PolSAR Data
Authors: Nie Yuliang , Zeng Qiming , Zhang Haizhen , Wang Qing 
Published: March 2021

Synthetic aperture radar (SAR) is an effective tool in detecting building damage. At present, more and more studies detect building damage using a single post-event fully polarimetric SAR (PolSAR) image, because it permits faster and more convenient damage detection work. However, the existence of non-buildings and obliquely-oriented buildings in disaster areas presents a challenge for obtaining accurate detection results using only post-event PolSAR data. To solve these problems, a new method is proposed in this work to detect completely collapsed buildings using a single post-event full polarization SAR image. The proposed method makes two improvements to building damage detection. First, it provides a more effective solution for non-building area removal in post-event PolSAR images. By selecting and combining three competitive polarization features, the proposed solution can remove most non-building areas effectively, including mountain vegetation and farmland areas, which are easily confused with collapsed buildings. Second, it significantly improves the classification performance of collapsed and standing buildings. A new polarization feature was created specifically for the classification of obliquely-oriented and collapsed buildings via development of the optimization of polarimetric contrast enhancement (OPCE) matching algorithm. Using this developed feature combined with texture features, the proposed method effectively distinguished collapsed and obliquely-oriented buildings, while simultaneously also identifying the affected collapsed buildings in error-prone areas. Experiments were implemented on three PolSAR datasets obtained in fully polarimetric mode: Radarsat-2 PolSAR data from the 2010 Yushu earthquake in China (resolution: 12 m, scale of the study area: 50 km2); ALOS PALSAR PolSAR data from the 2011 Tohoku tsunami in Japan (resolution: 23.14 m, scale of the study area: 113 km2); and ALOS-2 PolSAR data from the 2016 Kumamoto earthquake in Japan (resolution: 5.1 m, scale of the study area: 5 km2). Through the experiments, the proposed method was proven to obtain more than 90% accuracy for built-up area extraction in post-event PolSAR data. The achieved detection accuracies of building damage were 82.3%, 97.4%, and 78.5% in Yushu, Ishinomaki, and Mashiki town study sites, respectively.
Restorative Justice Sebagai Alternatif Penyelesaian Perkara Pidana
Authors: Sarbini Ilyas , Sukirman  , Ma'arij Aman 
Published: March 2021

Kehidupan yang tertib dan damai dalam tatanan masyarakat adalah menjadi harapan, namun dalam interaksi antar individu di dalamnya akan ada saja perbedaan-perbedaan sesuai kepentingan masing-masing sehingga dapat menimbulkan benturan kepentingan yang satu dengan yang lain yang dapat mengganggu keseimbangan tatanan masyarakat dapat berupa konflik atau pertikaian.
Sekarang marak terjadi, masyarakat cenderung menggunakan kekerasan dalam
penyelesaian sengketa yang mereka alami, dengan harapan dapat diselesaikan dengan cepat dan biaya lebih murah. Masyarakat memandang bahwa dengan melakukan kekerasan, sengketa yang terjadi akan dapat diselesaikan,sehingga dalam kehidupan masyarakat yang demikian, maka angka konflik atau pertikaian terus meningkat dan menjadi fenomena biasa dalam masyarakat baik terkait konflik antara dua individu maupun lebih. Fenomena ini berakibat pada penumpukan perkara di lembaga-lembaga peradilan, belum lagi yang tidak dilaporkan yang dapat menjadi bara dalam jiwa korban maupun pelaku yang sewaktu-waktu dapat meledak dan memicu eskalasi konflik yang semakin luas. Kecenderungan orang berprasangka buruk terhadap proses peradilan konvensional sekarang, disana disangka terjadi adu loby mana yang kuat dia yang menang dan malah dikatakan menang jadi arang kalah jadi abu. Prasangka buruk itu yang membuat proses peradilan tidak dipercaya, yang berakibat kecenderungan orang melampiaskan penyelesaian masalahnya dengan main hakim sendiri
Impact Covid-19: Potret Transformasi Pendidikan melalui Pembelajaran Daring di Kecamatan Maesan, Bondowoso
Authors: Istiqomah Laili , Habibi Azwar 
Published: March 2021

The Covid-19 pandemic has had a major impact on various sectors, one of which is education. The world of education also feels the impact. Educators must ensure teaching andlearning activities continue, even though students are at home. It is hoped that the status ofa pandemic will pass quickly with increasing public awareness to join and break the chainof spreading this virus. This dedication article will address two issues; First, trying to lookat the problems of parents and school-age children during the pandemic in terms of education; Second, trying to build public awareness to prevent Covid-19. The results of this service are: First, providing solutions to parents and school-age children for problems that arise in the midst of a pandemic in the aspect of education; Second, increase public understanding of Covid-19 and how to prevent it.
Keywords: Impact Covid-19, Educational Transformation, Online Learning.
Abstrak
Pandemi Covid-19 berdampak besar pada berbagai sektor, salah satunya pendidikan. Dunia pendidikan juga ikut merasakan dampaknya. Pendidik harus memastikan kegiatan belajar mengajar tetap berjalan, meskipun peserta didik berada di rumah. Status pandemi diharapkan cepat berlalu dengan peningkatan kesadaran masyarakat untuk ikut andil memutus mata rantai penyebaran virus ini. Artikel pengabdian ini akan membahas dua masalah; Pertama, mencoba untuk mengetahui problematika orang tua dan anak usia sekolah di saat pandemi dalam aspek pendidikan; Kedua, mencoba membangun kesadaran masyarakat untuk pencegahan virus Covid-19. Hasil dari pengabdian ini adalah: Pertama, memberikan solusi pada orang tua dan anak usia sekolah atas problematika yang muncul di tengah pandemi dalam aspek pendidikan; Kedua, meningkatkan pemahaman masyarakat tentang Covid-19 dan cara pencegahannya.
Kata Kunci: Impact Covid-19, Transformasi Pendidikan, Pembelajaran Daring.
Pojęcie prawdy w Adventures of Ideas Alfreda Northa Whiteheada
Authors: Lisiak Bogdan 
Published: March 2021

Zagadnienie prawdy jest jednym z podstawowych problemów filozoficznych, poruszanych przez A. N . Whiteheada w Adventures of Ideas. Zanim w niniejszym artykule skoncentrujemy się na problemie prawdy w tym dziele, omówimy kilka podstawowych terminów filozofii Whiteheada niezbędnych do zrozumienia jego koncepcji prawdy. Podstawowym pojęciem w whiteheadowskiej wizji świata jest aktualne zdarzenia (actual occasion). Aktualne zdarzenia autor Przygód idei nazywa także aktualnymi bytami (actual entities). Aktualne zdarzenie stanowi najmniejsze jednostki rzeczywistości. Ich statut jest zbliżony do zdarzeń czasowoprzestrzennych. Zdarzenia tworzą ciągi (nexus). Powiązane ze sobą ciągi zdarzeń mogą tworzyć zjawiska w sensie fizycznym. Aktualne zdarzenia są jakby elementami struktury rzeczywistości, której konstytutywna cech jest proces stawania się (becoming). Proces ten jest twórczym rozwojem dziki zasadzie kreatywności (creativity), która umożliwia pojawienie się w rzeczywistości nowych zdarzeń, albo ciągów aktualnych zdarzeń. Proces kreatywnego rozwoju rzeczywistości, według Whiteheada, nie powinien być utożsamiany z wariabilizmem Heraklita. Albowiem jego racjonalność jest zapewniona przez tzw. obiekty ponadczasowe (eternal objects), które gwarantują racjonalność procesu powstającej struktury otaczającego nas świata. Obiekty ponadczasowe determinują zakres możliwości ewolucji ciągów zdarzeń (occasions) i są one potencjalnościami odpowiedzialnymi za determinowanie kierunków rozwoju rzeczywistości. Według Whiteheada zdarzenia i zjawiska zmiennego świata partycypują w obiektach ponadczasowych. Powiazania zachodzące pomiędzy aktualnymi zdarzeniami, obiektami ponadczasowymi i podmiotem poznającym są określone za pomocą pojecia odczucia (feeling) i ujęcia (prehension). Ujęcie (prehension) polega na powiazaniu konkretnego, aktualnego zdarzenia ze zdarzeniami, które wystąpiły w przeszłości. Ukazuje ono także powiazanie danego zdarzenia z wariantami ewolucji rzeczywistości w przyszłości, która jest określana przez obiekty ponadczasowe. Innymi słowy ujęcia są jakby wektorami ukazującymi kierunki procesu kształtowania się struktury rzeczywistości. Pojęcie odczucia (feeling) odzwierciedla możliwość włączenia nowych danych do struktury bytu aktualnego lub podmiotu.
Ignacy Dec. Dwie antropologie. Tomaszowa i Marcelowa teoria człowieka [Deux anthropologies. La théorie de Thomme de Thomas d'Aquin et de Marcel]
Authors: Darowski Roman 
Published: March 2021

L'auteur se propose de comparer la theorie de I'homme de saint Thomas d'Aquin et de Gabriel Marcel. II est interessant de faire une comparaison entre ces deux penseurs, car la philosophie de Gabriel Marcel est souvent pergue comme un nouveau type de philosophie chretienne. On dit parfois que la philosophie de ce dernier est beaucoup plus proche de I'homme contemporain que ne l'est celle de Thomas d'Aquin.
Stanisław Głaz. Intensywność doświadczenia religijnego a koncepcja siebie [Intensity of Religious Experience and Self-Concept]
Authors: Grzywacz Robert 
Published: March 2021

The attempts of the psychological interpretation of religious experience have started at the end of the 19th century. They were undertaken by F. Schleiermacher, E. Starbuck and W. James, followers of the subjective conception of religion and religious experience. They reduced religion only to subject-empiristic sphere, but for them religion
is still a kind of experience of contact with something that could be called „Divine".
Stanisław Obirek. Wizja państwa w nauczaniu jezuitów polskich w latach 1564-1668 [The Vision of the State in the Teaching of the Polish Jesuits in 1564-1668]
Authors: Pyszka Stanisław 
Published: March 2021

There have been many papers on the Jesuit relationship with the State and with the civil powers in the Western Countries. But there are no such elaborations concerning Poland. However, it was not a central aim, the Jesuits had to engage in the political situation of the country where they did His apostolic work though they did not commit themselves personally in the policy. The Jesuits had their own concept of the State and the state policy. And they showed great caution in preparing the policy treaties in order to save impartiality.
Encyklopedia wiedzy o jezuitach na ziemiach Polski i Litwy, 1564-1995 [Encyclopaedia of Information on the Jesuits on the Territories of Poland and Lithuania, 1564-1995. Ed. L. Grzebień SJ]
Authors: Grzebień Ludwik 
Published: March 2021

The Jesuits have played a significant part in the history of Poland from the religious, social and cultural aspects. Little wonder, then, that over 5,000 books and articles have been devoted to the Order and its individual members in Poland. However, the Jesuit Order does not as yet have a full synthesis of its own on the subject of its history in Poland. The only work of a synthetic nature, by S. Załęski, Jezuici w Polsce [The Jesuits in Poland], (Lwów-Krakow, 1900-1906), notwithstanding the usefulness of its content still today, is no longer up to the modem expectations and standards required by historians. The compilation of a new comprehensive synthesis will call for the accumulation and presentation of the vast volume of material concerning the various aspects of the Order's history.
Indywidualizm i elita w epoce informacji
Authors: Nyíri Kristóf 
Published: March 2021

Wolność to idea, w imię której toczy się dzisiaj proces wyzwalania się Europy Wschodniej. Jest to potężna idea, która jednak w obecnych warunkach kryje w sobie również pewne niebezpieczeństwo, ponieważ podczas wyzwalania się spod dyktatury, uniezależniania się od wpływów Rosji i przebijania się ku klasycznym wartościom wolnosci obywatelskiej, można łatwo osiągnąć pozorne zwycięstwo; bezużyteczne zwycięstwo na peryferiach historii. Trzeba sobie obecnie zdac sprawę z tego, że Europa Wschodnia nie jest wcale widownią wydarzeń, mających zasadnicze znaczenie dla świata jako całości. Trzeba uświadomić sobie, że dzisiaj inna, nowa rewolucja odciska swe piętno na historii swiata. Jest to rewolucja technologiczna, która rozgrywa się na calkiem innej płaszczyźnie; rewolucja, która przemienia nowoczesne przemysłowe
społeczeństwo w post-nowoczesne społeczenstwo informacji. Przekształca się ono w społeczenstwo, w którym źródłem bogactwa nie jest już surowiec i kapitał, lecz wiedza - dostęp do informacji i umiejętność
obchodzenia się z nią. „Nowa cywilizacja wkracza w nasze życie" - tak brzmią znane słowa Alvina Tofflera.
II problema dell'amicizia nel pensiero di Aristotele
Authors: Majkrzak Henryk 
Published: March 2021

Nel pensiero umano il problema dell’amicizia - cioe il problema del affetto mutuo fra due persone o sentimento che trasporta verso l’altro, originate da uma adequata conformita di cui i caratteri tipici sono il disinteresse e la reciprocita - occupa un posto significante, perche ogni uomo e fatto per rapportarsi a un cuore che ha bisogno di complementarieta, di comimione, di discemere e di camminare insieme. Grazie all’amicizia l'uomo puo diventare un paradise per l’uomo. La comprensione del problema dell’amicizia esprime il livello della civilta attuale. La nostra societa e purtroppo piu una societa di mercato, di utile economico, di competizione, di potere, dell’uomo lupo all’altro uomo, che ima societa di rapporti veramente umani. Inoltre l’amicizia sembra trasferita nel campo dell’utile particolare per aveme vantaggi, al di fuori del merito.
The Jesuits and the Polish Sarmatianism
Authors: Obirek Stanisław 
Published: March 2021

The road into Poland was not easy for the Society of Jesus. Although there were some Polish bishops, such as Stanisław Hozjusz [Stanislaus Hosius] and the successor to his See of Varmia, Marcin Kromer [Martinus Cromerus], who took steps to induce the authorities at Rome to allow the Jesuits to come and establish themselves in Poland-Lithuania, seeing the Order as an effective auxiliary agency for the practical implementation of the reforms passed at the Council of Trent, their efforts were isolated attempts which failed to find sympathy with even the rest of the bishops of Poland, not to speak of other social groups.
Kształtowanie postawy obywatelskiej, Zbiór tekstów pod redakcją Piotra Lenartowicza SJ. [The Formation of the Civic Responsability. Texts edited by Piotr Lenartowicz, S.J.]
Authors: Tieplakoff Arkadiusz 
Published: March 2021

This book contains five lectures which had been delivered at the Jesuit Faculty of Philosophy in Cracow. Each of them is different in subject-matter, but what makes them one book is the common concern for the social affairs. It is addressed to the general reader. Those readers who are uninitiated in the field of broadly-understood politology could find there a short dictionary of political-ethical terms. It would not just facilitate the reports' comprehension, but also widens an outlook by introducing the semantic aspects of terminology that sometimes is left out of account.
Wprowadzenie do personalistycznej koncepcji wszechświata według Johna Macmurray (1891–1976)
Authors: Rybowicz Artur 
Published: March 2021

Zdaniem Johna Macmurray, teoretyczny i egocentryczny charakter tradycyjnej filozofii byl źródłem subiektywizmu i dualistycznego postrzegania rzeczywistości, co w konsekwencji prowadziło do zafałszowania obrazu świata, człowieka i Boga. W swej filozoficznej karierze Macmurray bardzo wcześnie, bo już w latach trzydziestych zdał sobie sprawę z niebezpieczeństwa, jakie dualistyczne myślenie niosło ze sobą dla osobowego życia ludzkości, a w konsekwencji i dla wiary religijnej. Kulturowym i społecznym skutkiem dualistycznych sposobów myślenia w filozofii, teologii, sztuce i nauce było bowiem zaznaczające się na coraz
większą skalę w międzywojennej Europie osłabienie integralności życia osobowego, a tym samym zarzucenie wiary religijnej i przyjęcie światopoglądu ateistycznego. Dlatego też już od początku swojej filozoficznej refleksji postawił on sobie za cel rozpoznanie filozoficznych żródeł i nurtów myślenia, które charakteryzowały współczesny okres historii i zniekształcały rozumienie osoby i życia osobowego. Jego poszukiwania doprowadziły go do przekonania, że głównym źródłem myślenia subiektywistycznego we współczesnej filozofii jest filozofia kartezjanska oraz jej kontynuacja w kantyzmie i nurtach filozoficznych
z niego się wywodzących.