bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract 473: Identification of Apolipoproteins Using Feature Selection Technique
Authors: Tang Hua , Lin Hao 
Published: June 2021

Objective:
Apolipoproteins are of great physiological importance and are associated with different diseases such as dyslipidemia, thrombogenesis and angiocardiopathy. Apolipoproteins have therefore emerged as key risk markers and important research targets yet the types of apolipoproteins has not been fully elucidated. Accurate identification of the apoliproproteins is very crucial to the comprehension of cardiovascular diseases and drug design. The aim of this study is to develop a powerful model to precisely identify apolipoproteins.

Approach and Results:
We manually collected a non-redundant dataset of 53 apoliproproteins and 136 non-apoliproproteins with the sequence identify of less than 40% from UniProt. After formulating the protein sequence samples with
g
-gap dipeptide composition (here
g
=1~10), the analysis of various (ANOVA) was adopted to find out the best feature subset which can achieve the best accuracy. Support Vector Machine (SVM) was then used to perform classification. The predictive model was evaluated using a five-fold cross-validation which yielded a sensitivity of 96.2%, a specificity of 99.3%, and an accuracy of 98.4%. The study indicated that the proposed method could be a feasible means of conducting preliminary analyses of apoliproproteins.

Conclusion:
We demonstrated that apoliproproteins can be predicted from their primary sequences. Also we discovered the special dipeptide distribution in apoliproproteins. These findings open new perspectives to improve apoliproproteins prediction by considering the specific dipeptides. We expect that these findings will help to improve drug development in anti-angiocardiopathy disease.

Key words:

Apoliproproteins
Angiocardiopathy
Support Vector Machine
Impact of Chronic Hypertension and Antihypertensive Treatment on Adverse Perinatal Outcomes: Systematic Review and Meta‐Analysis
Authors: Al Khalaf Sukainah Y. , O'Reilly Éilis J. , Barrett Peter M. , B. Leite Debora F. , Pawley Lauren C. , McCarthy Fergus P. , Khashan Ali S. 
Published: June 2021

Background
Maternal chronic hypertension is associated with adverse pregnancy outcomes. Previous studies examined the association between either chronic hypertension or antihypertensive treatment and adverse pregnancy outcomes. We aimed to synthesize the evidence on the effect of chronic hypertension/antihypertensive treatment on adverse pregnancy outcomes.

Methods and Results
Medline/PubMed, EMBASE, and Web of Science were searched; we included observational studies and assessed the effect of race/ethnicity, where possible, following a registered protocol (CRD42019120088). Random‐effects meta‐analyses were used. A total of 81 studies were identified on chronic hypertension, and a total of 16 studies were identified on antihypertensive treatment. Chronic hypertension was associated with higher odds of preeclampsia (adjusted odd ratio [aOR], 5.43; 95% CI, 3.85–7.65); cesarean section (aOR, 1.87; 95% CI, 1.6–2.16); maternal mortality (aOR, 4.80; 95% CI, 3.04–7.58); preterm birth (aOR, 2.23; 95% CI, 1.96–2.53); stillbirth (aOR, 2.32; 95% CI, 2.22–2.42); and small for gestational age (SGA) (aOR, 1.96; 95% CI, 1.6–2.40). Subgroup analyses indicated that maternal race/ethnicity does not influence the observed associations. Women with chronic hypertension on antihypertensive treatment (versus untreated) had higher odds of SGA (aOR, 1.86; 95% CI, 1.38–2.50).

Conclusions
Chronic hypertension is associated with adverse pregnancy outcomes, and these associations appear to be independent of maternal race/ethnicity. In women with chronic hypertension, those on treatment had a higher risk of SGA, although the number of studies was limited. This could result from a direct effect of the treatment or because severe hypertension during pregnancy is a risk factor for SGA and women with severe hypertension are more likely to be treated. The effect of antihypertensive treatment on SGA needs to be further tested with large randomized controlled trials.
Risk Factors and Outcomes of Recurrent Drug‐Eluting Stent Thrombosis: Insights From the REAL‐ST Registry
Authors: Enomoto Soichiro , Kuramitsu Shoichi , Shinozaki Tomohiro , Ohya Masanobu , Otake Hiromasa , Yamanaka Futoshi , Shiomi Hiroki , Natsuaki Masahiro , Nakazawa Gaku , Ando Kenji , Kadota Kazushige , Saito Shigeru , Tamura Toshihiro , Kimura Takeshi , Toyota Fumitoshi , Otsuji Hideaki , Sugihara Makoto , Serikawa Takeshi , Matsuo Hitoshi , Tanigaki Toru , Noda Toshiyuki , Kato Takashi , Dai Kazuoki , Iwasaki Masamichi , Takaya Tomofumi , Dan Kazuhiro , Okino Hideto , Toyofuku Mamoru , Saito Makoto , Kim Kite , Otake Hiromasa , Nagasawa Akira , Nakayoshi Takaharu , Chibana Hidetoshi , Kimura Takeshi , Shimooka Yoshinori , Shibata Yoshisato , Ogata Kenji , Kurogi Kazumasa , Sakamoto Ryohei , Kataoka Tetsuro , Ishii Mitsuru , Yamamoto Fumi , Kawamoto Hiroyoshi , Yabushita Hiroto , Kozuki Amane , Kobayashi Yohei , Higami Hirooki , Natsuaki Masahiro , Suzuyama Hiroto , Sakakura Kenichi , Watanabe Yusuke , Yamasaki Seiji , Katagiri Yuki , Horie Kazunori , Takii Toru , Saito Shigeru , Yamanaka Futoshi , Tamura Toshihiro , Enomoto Soichiro , Nakazawa Gaku , Matsumoto Shingo , Tanaka Nobuhiro , Nishina Hidetaka , Kakefuda Yuki , Sonoda Shinjo , Anai Reo , Doijiri Tatsuki 
Published: June 2021

Background
Stent thrombosis (ST) after drug‐eluting stent (DES) implantation remains a life‐threatening complication. Recurrent ST (RST) is not a rare phenomenon, potentially contributing to high mortality after the index ST events. However, little evidence is available about the incidence, risk factors, and clinical outcomes of definite RST after DES thrombosis.

Methods and Results

From REAL‐ST (Retrospective Multicenter Registry of ST After First‐ and Second‐ Generation DES Implantation), this study evaluated 595 patients with definite ST (first‐generation DES thrombosis, n=314; second‐generation DES thrombosis, n=281). During a median follow‐up of 31 months, we identified 32 patients with definite RST after first‐generation DES thrombosis (n=18) and second‐generation DES thrombosis (n=15). Cumulative incidence of RST was 4.5% and 6.0% at 1 and 5 years, respectively, which did not significantly differ between first‐generation DES thrombosis and second‐generation DES thrombosis. Independent predictors of definite RST were early ST (hazard ratio [HR], 2.38; 95% CI, 1.06–5.35 [
P
=0.035]) and multivessel ST (HR, 3.47; 95% CI, 1.03–11.7 [
P
=0.044]). Definite RST was associated with a 2.8‐fold increased risk of mortality (adjusted HR, 2.78; 95% CI, 1.35–5.73 [
P
=0.006]).

Conclusions
Cumulative incidence of definite RST did not significantly differ between first‐generation DES thrombosis and second‐generation DES thrombosis. Early ST and multivessel ST were risk factors of definite RST. Definite RST significantly increased mortality after DES thrombosis, highlighting the clinical importance of preventing RST to improve outcomes of patients with ST.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: UMIN000025181.
Unexpected pancytopenia: Dasatinib induced aplastic anemia in chronic myeloid leukemia
Authors: Feld Jonathan , Steinberg Amir , El Jamal Siraj M , Shapira Ilan 
Published: June 2021

Introduction The use of TKIs in CML has dramatically altered the natural course of the disease and improved outcomes for patients. TKIs overall have a very favorable safety profile. Dasatinib, a second generation TKI, is commonly used as a first-line treatment option in CML. Case report We describe the first two reported cases of first-line dasatinib induced aplastic anemia in CML. In both patients, pancytopenia occurred within one year of diagnosis/starting dasatinib. Both bone marrow biopsies showed hypocellularity with mild fibrosis and persistent BCR-Abl1 positivity. Management & outcome Dose reduction was attempted without success in both patients. In one patient, multiple TKIs were trialed, while in the other, growth factor support was attempted; neither regimen was effective. Ultimately, the cytopenias associated with dasatinib were only resolved after immunosuppression in one patient and allogeneic stem cell transplant in the other patient. Discussion Prior reports have shown that aplasia/aplastic anemia can rarely be associated with imatinib and nilotinib. Here we show that dasatinib can lead to this phenomenon as well. This diagnosis should be considered in patients with CML who unexpectedly develop cytopenias.
The burden of central line-associated bloodstream infections in children with medical complexity
Authors: Scarselli Alessia , Smarrazzo Andrea , De Sanctis Francesco , Ravà Lucilla , Carletti Michaela , Ciofi Degli Atti Marta , Aversa Marcella , Drago Riccardo , Crocoli Alessandro , Geremia Caterina , Guerricchio Andrea , Lucignano Barbara , Campana Andrea , De Ioris Maria Antonietta , Perrotta Daniela 
Published: June 2021

Background: Central line-associated bloodstream infections (CLABSI) are significant cause of complications in pediatric intensive care units (PICUs). An emerging challenge are CLABSIs in children with medical complexity (CMC) admitted to PICU. CMC are patients with chronic conditions with or without neurological impairment needing for tracheostomy and/or home mechanical or non-invasive ventilation and/or gastrostomy/jejunostomy. We evaluate CLABSI incidence in a PICU with high prevalence of CMC. Methods: This was a retrospective study in the PICU of the Bambino Gesù Children Hospital from January 2017 to December 2020. The medical records were reviewed and demographic, clinical and microbiological data were extracted. CLABSI were defined according to the Center for Disease Control and Prevention’s National Healthcare Safety Networks (NHSN) surveillance. Results: A total of 101 children with 125 central lines (CLs) were included; 79/101 (78%) patients were CMC and 50/101 (50%) had a thracheostomy. CLABSI incidence was 2.75/1000 CL-days (9 cases/3269 CL-days); incidence was 0 in patients without underling conditions and 3.14/1000 in CMC ( p < 0.001). CLABSI were due to gram negative bacteria in five patients, Candida spp in three and Staphylococcus hominis in one. CLs were removed in eight cases while in the later one, with CLABSI due to Pseudomonas aeruginosa, a conservative strategy was adopted cause of unavailable alternative venous access and removed at discharge with negative culture. All patients recovered. Conclusions: A target 0% CLABSI was possible in critically ill children without underling condition while a high incidence was reported in CMC and sustained by a peculiar CLABSI ecology. This ecology should be considered when a CLABSI was suspected in CMC for prompt antibiotics stewardship.
Telehealth outpatient coronavirus disease 2019 case management at a tertiary hospital in Sydney
Authors: Micallef Milton , Hurley Siobhan , Brell Nadiya , Cook Rebekah , Post Jeffrey , Overton Kristen 
Published: June 2021

Introduction Coronavirus disease 2019 is an acute respiratory illness caused by severe acute respiratory syndrome coronavirus 2. The coronavirus disease 2019 pandemic upended the traditional paradigm of face-to-face provision of healthcare in the Australian context; as such, a telehealth model of active case management was implemented in our public health system, even though there was little supporting data for the safety of delivering patient care remotely to home-isolation patients in the setting of a highly infectious and potentially fatal illness. Methods A retrospective, single-centre, observational cohort study was performed over 6 weeks commencing 12 March 2020, including patients with coronavirus disease 2019 undergoing home isolation and being actively monitored by a coronavirus disease 2019 telephone assessment clinic. Outcomes assessed comprised: duration of active case follow-up, average number of telephone calls per patient, average number of hours managing each patient, treatment required including presentation to the emergency department or admission to hospital, patient characteristics and utilisation of other health services. Results Of 5223 severe acute respiratory syndrome coronavirus 2 tests performed, 170 individuals (3.25%) tested positive. A total of 158 were included: 76 (47.5%) male and median age 31 years (range 18-94). Median symptom duration was 13 days (interquartile range 6, range 2-34). Median length of coronavirus disease 2019 telephone assessment clinic admission was 10 days (interquartile range 7, range 3-32). A total of 1151 telephone patient encounters were undertaken, with a median of six phone calls made to each patient (interquartile range 5, range 1-20). Ten patients required repeat clinic review; all but one returned home. Six presented to emergency department, with three of these being admitted. In total, there were six admissions: one from the clinic, three from the emergency department and two direct from home (bypassing emergency department). Only four of the six admissions (or 2.5% of all patients) required low-flow oxygen therapy; none required high-flow oxygen or assisted ventilation. The remaining 140 patients (88.6%) were safely managed at home without complications. Discussion A telehealth model of care is safe, efficient and cost-effective for the management of mild-to-moderate coronavirus disease-19 and facilitates home isolation, especially of a low-risk population, thus providing reassurance that this model is sound and suitable for ongoing use.
Psychosocial treatment preferences of persons living with young-onset dementia and their partners
Authors: Grunberg Victoria A , Bannon Sarah M , Reichman Mira , Popok Paula J , Vranceanu Ana-Maria 
Published: June 2021

Persons living with young-onset dementia and their partners often experience elevated emotional distress as they cope with an unexpected progressive illness during an active life stage (typically ages 45–64 years). Despite their heightened emotional distress, psychosocial resources are both limited and lack the specificity to meet the unique needs of both partners. Our aim was to gain an in-depth understanding of the psychosocial treatment preferences of persons with young-onset dementia and their partners—an important first step in developing a tailored intervention. We conducted semi-structured dyadic interviews with persons with young-onset dementia and their partners ( N = 23) and used a hybrid deductive–inductive approach to thematic analysis. We identified 12 themes across four domains: (1) perceptions of available and lacking resources, (2) preferences for program content, (3) preferences for program format, and (4) barriers and facilitators to participation. Couples indicated there is a lack of specific and family-oriented resources, which can create more stress and relationship strain. Couples endorsed support for a virtual, dyadic intervention delivered shortly after diagnosis focused on providing tools to cope with difficult emotions and symptom progression and enhance communication and meaningful daily living. They also identified potential barriers to program participation and offered suggestions to promote engagement. By using a qualitative approach, we were able to gather nuanced information that can be used to directly inform a feasible, accepted, and person-centered psychosocial intervention for persons with young-onset dementia and their partners.
Body composition in patients with rheumatoid arthritis: a narrative literature review
Authors: Letarouilly Jean-Guillaume , Flipo René-Marc , Cortet Bernard , Tournadre Anne , Paccou Julien 
Published: June 2021

There is growing interest in the alterations in body composition (BC) that accompany rheumatoid arthritis (RA). The purpose of this review is to (i) investigate how BC is currently measured in RA patients, (ii) describe alterations in body composition in RA patients and (iii) evaluate the effect on nutrition, physical training, and treatments; that is, corticosteroids and biologic Disease Modifying Anti-Rheumatic Disease (bDMARDs), on BC in RA patients. The primary-source literature for this review was acquired using PubMed, Scopus and Cochrane database searches for articles published up to March 2021. The Medical Subject Headings (MeSH) terms used were ‘Arthritis, Rheumatoid’, ‘body composition’, ‘sarcopenia’, ‘obesity’, ‘cachexia’, ‘Absorptiometry, Photon’ and ‘Electric Impedance’. The titles and abstracts of all articles were reviewed for relevant subjects. Whole-BC measurements were usually performed using dual energy x-ray absorptiometry (DXA) to quantify lean- and fat-mass parameters. In RA patients, lean mass is lower and adiposity is higher than in healthy controls, both in men and women. The prevalence of abnormal BC conditions such as overfat, sarcopenia and sarcopenic obesity is significantly higher in RA patients than in healthy controls; these alterations in BC are observed even at an early stage of the disease. Data on the effect treatments on BC in RA patients are scarce. In the few studies published, (a) creatine supplementation and progressive resistance training induce a slight and temporary increase in lean mass, (b) exposure to corticosteroids induces a gain in fat mass and (c) tumour necrosis factor alpha (TNFα) inhibitors might be associated with a gain in fat mass, while tocilizumab might be associated with a gain in lean mass. The available data clearly demonstrate that alterations in BC occur in RA patients, but data on the effect of treatments, especially bDMARDs, are inconsistent and further studies are needed in this area.
Factors Associated with Clinician Adherence to USPSTF Diabetes Screening Recommendations
Authors: Banerjee Elaine Seaton , Shaak Kyle , Burgess Nicole , Johnson Melanie , Careyva Beth 
Published: June 2021

Introduction/Objectives: Diabetes and prediabetes impact nearly half of the US adult population and are associated with significant health risks but may be underdiagnosed. Effective screening may improve diagnosis and give patients opportunity to manage their disease. The purpose of this study was to determine screening rates, identify characteristics predictive of screening, and evaluate correct diagnosis of diabetes and prediabetes. Methods: Retrospective chart review of 71 433 patients eligible for diabetes screening, defined by completing A1c test within the 3-year study period. Results: A total of 31.3% of eligible patients received diabetes screening. Factors associated with screening include older age, female sex, non-white race, Hispanic ethnicity, Medicare or Medicaid insurance, higher BMI, and having a medical comorbidity. History of prediabetes or gestational diabetes were the strongest predictors for diabetes screening, but history of gestational diabetes was under-documented. Of those screened, 10.4% had a result consistent with diabetes and 51.8% had a result consistent with prediabetes. However, 52.9% of these patients had a missed diagnosis. Conclusions: Findings of this study indicate the need for uniform coverage for diabetes screening for all insurances, increased documentation of gestational diabetes to improve screening for patients with this history, and improving accurate diagnosis after screening is completed.
Social Enterprises of Immigrants: A Panacea for the Finnish Labour Market?
Authors: Yeasmin Nafisa , Koivurova Timo 
Published: June 2021

Research questions: The objectives of this study are to identify the need for Social Enterprises (SEs) as an alternative form of working in the Finnish labour market, what alternative forms of co-operation between such types of SEs could be and how larger local companies can support the sustainable operation of these small SEs by employing immigrants and the long-term unemployed. Theory: This article draws on the corporate social responsibility CSR theory of traditional enterprises to better explain the factors that can facilitate co-operation between SEs and private enterprises, thereby reaching the sustainable operation of SEs that are run by socially disadvantaged groups of people in Lapland. Phenomenon studied: SE is a new phenomenon in Lapland. There are a few SEs in the region that are struggling to maintain their existence in a sustainable manner. It is harder for the members of such SEs to run businesses or to work and to become successful in Lapland; however, obtaining employment or running a proprietorship is not an alternative (Yeasmin, 2016) for these disadvantaged people. Case context: The article contributes to the studies on the economic integration and labour market sustainability of immigrants and long-term job seekers, and particularly to the socio-economic integration of the long-term unemployed by focusing on the necessity-driven social entrepreneurship networking model in a sparsely populated region, that being the region of Lapland in Northern Finland. Findings: The disadvantaged groups need access to the labour market in Lapland, and social alliances between various partners (e.g., private, public and SE) under different social circumstances (e.g., CSR) can generate alternative options for co-operation to sustain the existence of such SEs in Lapland. An analysis explores future recommendations for co-operation that might sustain SE’s existence and development and might also increase long-term prospects for targeted SEs. Discussion: Lapland-based SEs operated by immigrants or the long-term unemployed are issues and themes that do not fall within the responsibility of any single authority or any single sector. Successfully running SEs demands positive interaction and social innovation strategies among many social partners. Networking with a variety of public stakeholder groups alongside the private sector needs to see an investment of social resources for mapping the phenomena on the topic of social economy, which is a social innovation process that might enable such SEs to have successful outcomes in Lapland.
The employer’s commitment: Conceptualization, development, and validation of a scale
Authors: García-Cruz Joaquín , Valle-Cabrera Ramón 
Published: June 2021

This research aimed to achieve two sequential objectives: (1) to provide conceptual support for the idea of organizational commitment toward employees (the employer’s commitment), showing differences in concepts such as perceived organizational support, high commitment work systems, human resource (HR) philosophy, and psychological contracts, and (2) to develop a scale to measure employer’s commitment. To define the construct, we extrapolated the three-component model (TCM) dimensions (affective, continuance, and normative) from the individual to the organizational levels. To develop the new scale, we first used the Delphi method to determine the items in the questionnaire. Second, to verify the validity and reliability of the new scale, data collected from two sample populations (financial and hospitality sectors) were examined. The results suggest that the three dimensions of TCM in the final construct are independent and autonomous. JEL CLASSIFICATION: M12