bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in Perceived and Predicted Bleeding Risk in Older Adults With Atrial Fibrillation: The SAGE‐AF Study
Authors: Bamgbade Benita A. , McManus David D. , Helm Robert , Mehawej Jordy , Gurwitz Jerry H. , Mailhot Tanya , Abu Hawa O. , Goldberg Robert , Wang Ziyue , Tisminetzky Mayra , Pierre‐Louis Isabelle C. , Saczynski Jane S. 
Published: August 2021

BackgroundLittle research has evaluated patient bleeding risk perceptions in comparison with calculated bleeding risk among oral anticoagulant users with atrial fibrillation. Our objective was to investigate underestimation of bleeding risk and to describe the characteristics and patient‐reported outcomes associated with underestimation of bleeding risk.Methods and ResultsIn the SAGE‐AF (Systematic Assessment of Geriatric Elements in Atrial Fibrillation) study, a prospective cohort study of patients ≥65 years with atrial fibrillation, a CHA2DS2‐VASc risk score ≥2 and who were on oral anticoagulant therapy, we compared patients’ self‐reported bleeding risk with their predicted bleeding risk from their HAS‐BLED score. Among the 754 participants (mean age 74.8 years, 48.3% women), 68.0% underestimated their bleeding risk. Participants who were Asian or Pacific Islander, Black, Native American or Alaskan Native, Mixed Race or Hispanic (non‐White) (adjusted OR [AOR], 0.45; 95% CI, 0.24–0.82) and women (AOR, 0.62; 95% CI, 0.40–0.95) had significantly lower odds of underestimating their bleeding risk than respective comparison groups. Participants with a history of bleeding (AOR, 3.07; 95% CI, 1.73–5.44) and prior hypertension (AOR, 4.33; 95% CI, 2.43–7.72), stroke (AOR, 5.18; 95% CI, 1.87–14.40), or renal disease (AOR, 5.05; 95% CI, 2.98–8.57) had significantly higher odds of underestimating their bleeding risk.ConclusionsWe found that more than two‐thirds of patients with atrial fibrillation on oral anticoagulant therapy underestimated their bleeding risk and that participants with a history of bleeding and several comorbid conditions were more likely to underestimate their bleeding risk whereas non‐Whites and women were less likely to underestimate their bleeding risk. Clinicians should ensure that patients prescribed oral anticoagulant therapy have a thorough understanding of bleeding risk.
Weather Factors Associated with Extremely Large Fires and Fire Growth Days
Authors: Potter Brian E. , McEvoy Daniel 
Published: August 2021

Abstract“Megafires” are of scientific interest and concern for fire management, public safety planning, and smoke-related public health management. There is a need to predict them on time scales from days to decades. Understanding is limited, however, of the role of daily weather in determining their extreme size. This study examines differences in the daily weather during these and other smaller fires, and in the two sets of fires’ responses to daily weather and antecedent atmospheric dryness. Twenty fires of unusual size (over 36 400 ha), were each paired with a nearby large fire (10 100–30 300 ha). Antecedent dryness and daily near-surface weather were compared for each set of fires. Growth response to daily weather was also examined for differences between the two sets of fires. Antecedent dryness measured as the evaporative demand drought index was greater for most of the fires of unusual size than it was for smaller fires. There were small differences in daily weather, with those differences indicating weather less conducive to fire growth for the unusually large fires than the smaller fires. Growth response was similar for the two sets of fires when weather properties were between 40th and 60th percentiles for each fire pair, but the unusually large fires’ growth was observably greater than the smaller fires’ growth for weather properties between the 80th to 100th percentiles. Response differences were greatest for wind speed, and for the Fosberg fire weather index and variants of the hot-dry-windy index, which combine wind speed with atmospheric moisture.
CCTVs: Choices and Considerations
Authors: Goodrich Gregory L. , Quillman Robert D. 
Published: August 2021

The decision whether or not to purchase a CCTV can be a complex and difficult one, and the individual should realize that not to buy is as valid as to buy, in some cases. Decision should be based on the value of the CCTV system to the individual. The potential user should examine, carefully and critically, alternate optical aids and gather as much information as possible with professional help. Be critical of the information you receive, especially if it is not consistent with your own experience. In the end the choice is up to the user; who must live with the choice.
Current Therapeutic Approaches to Subglottic Stenosis in Patients With GPA: A Systematic Review
Authors: Almuhanna Ashjan , Almahboob Ayshah , Alhussien Ahmed , Aljurayyed Reem , Alammar Ahmed 
Published: August 2021

Background: The management of subglottic stenosis (SGS) in granulomatosis patients with polyangiitis (GPA) has no clear guidelines. This systematic review aimed to identify different surgical techniques and evaluate the outcomes of applied procedures. Methods: An electronic search was performed using 3 major databases, CINAHL, PubMed, and Clinical key, to include relevant studies published from the databases from inception through January 2017. All primary studies reporting treatment of SGS in cases with GPA were included. Articles were excluded if not relevant to the research topic or if they were duplicates, review articles, editorials, short comments, unpublished data, conference abstracts, case reports, animal studies, or non-English studies. Results: Thirteen papers were included in our systematic review with a total of 267 cases for the qualitative review Endoscopic approaches showed favorable outcomes with the need to use multiple procedures to achieve remission. The open transcervical approach showed excellent results mainly after failure of other endoscopic techniques. Tracheostomy was necessary for severe respiratory obstruction symptoms. Medical treatment was essential for stabilizing the active disease and therefore may enhance the success rate postoperatively. Conclusion: Subglottic stenosis in patients with GPA requires a multidisciplinary approach to provide optimal management regarding disease activity, grade of stenosis, and severity of symptoms.
Reproducibility of MRI Features of Uterine Leiomyomas: A Study on Interobserver Agreement and Inter-Method Agreement With Surgery
Authors: de Lima Guilherme Castilho Sorensen , Torres Ulysses S. , Bueno Leticia Ferreira , Rodi Gustavo Pedreira , Favaro Larissa Rossini , Neme Glaucy Lane , Pereira Ricardo Mendes Alves , de Mattos Leandro Accardo , D’Ippolito Giuseppe 
Published: August 2021

Purpose: To evaluate interobserver agreement in the interpretation of different MRI features of uterine leiomyomas (UL) according to observers’ experience, and to assess the inter-method reproducibility (MRI versus surgery) regarding the International Federation of Gynecology and Obstetrics (FIGO) classification. Methods: Retrospective study including UL patients who underwent MRI and surgical treatment. Four blinded observers (2 vs >10 years of experience) assessed UL regarding dimensions and volume; inner and outer mantles; FIGO classification; vascularization; degeneration; and diffusion-weighted imaging features. Uterine dimensions and volume were calculated. FIGO classification as ascertained by observers was compared to surgical findings. Intraclass correlation coefficient (ICC) estimates were used for interobserver comparison of numerical variables, and kappa statistic for categorical variables. Results: Thirty-five patients (26y-73y) with 61 UL were included in the interobserver analyses, and 31 patients (54 UL) had available data allowing retrospective surgical FIGO classification for assessment of inter-method reproducibility. Both groups of observers had good to excellent agreement in assessing UL (ICC = 0.980-0.994) and uterine volumes (ICC = 0.857-0.914), mantles measurement (ICC = 0.797-0.920), and apparent diffusion coefficient calculation (ICC = 0.787-0.883). There was substantial agreement for both groups regarding FIGO classification (κ = 0.645-0.767). Vascularization, degeneration and restricted diffusion had lower agreement, varying from reasonable to moderate. Inter-method agreement was reasonable (κ = 0.341-0.395). Conclusions: Interobserver agreement of MRI for UL was higher for quantitative than qualitative features, with a little impact of observers’ experience for most features. MRI agreement with surgery was reasonable. Further efforts should be taken to improve interobserver and inter-method reproducibility for MRI in this scenario.
Effect of inhaler and topical lavender oil on pain management of arteriovenous fistula cannulation
Authors: Tüzün Özdemir Sevda , Akyol Asiye 
Published: August 2021

Background: The recurrent arteriovenous fistula (AVF) intervention in the treatment of hemodialysis induces pain in patients. Lavender oil has analgesic, antimicrobial, and calming effects. This oil is widely used in patients to reduce anxiety and stress associated with pain caused by analgesics. Method: The present study is a randomized controlled and experimental clinical trial in which patients ( n = 90) who underwent hemodialysis with AVFs were randomly divided into three groups. The intensity of pain was measured in all patients at three different stages during the insertion of arterial needles for hemodialysis: (1) The topical application of 100% lavender essential oil, (2) the inhaler application of 100% lavender essential oil, and (3) no intervention. The placebo (water) was applied to groups 1 and 2. Results: Our findings revealed that the mean pre-application pain scores in hemodialysis patients were 57.58 ± 20.28 in the working group, 48.53 ± 20.23 in the control group, 19.49 ± 15.66 in the post-application group, and 45.33 ± 25.52 in the control group ( p < 0.005). The average pain scores after the application of lavender oil were 22.66 ± 15.35 in the inhaler lavender group, 16.33 ± 15.97 in the topical lavender group, and 45.33 ± 25.52 in the control group. Conclusions: After inhaler and topical application of lavender oil, a significant decrease in the severity of pain was recorded for patients at the time of arterial insertion of needles.
Exploring CSF neurofilament light as a biomarker for MS in clinical practice; a retrospective registry-based study
Authors: Rosenstein Igal , Axelsson Markus , Novakova Lenka , Blennow Kaj , Zetterberg Henrik , Lycke Jan 
Published: August 2021

Background: Neurofilament light (NFL) has been increasingly recognized for prognostic and therapeutic decisions. Objective: To validate the utility of cerebrospinal fluid NFL (cNFL) as a biomarker in clinical practice of relapsing-remitting multiple sclerosis (RRMS). Methods: RRMS patients ( n = 757) who had cNFL analyzed as part of the diagnostic work-up in a single academic multiple sclerosis (MS) center, 2001–2018, were retrospectively identified. cNFL concentrations were determined with two different immunoassays and the ratio of means between them was used for normalization. Results: RRMS with relapse had 4.4 times higher median cNFL concentration (1134 [interquartile range (IQR) 499–2744] ng/L) than those without relapse (264 [125–537] ng/L, p < 0.001) and patients with gadolinium-enhancing lesions had 3.3 times higher median NFL (1414 [606.8–3210] ng/L) than those without (426 [IQR 221–851] ng/L, p < 0.001). The sensitivity and specificity of cNFL to detect disease activity was 75% and 98.5%, respectively. High cNFL at MS onset predicted progression to Expanded Disability Status Scale (EDSS) ⩾ 3 ( p < 0.001, hazard ratios (HR) = 1.89, 95% CI = 1.44–2.65) and conversion to secondary progressive MS (SPMS, p = 0.001, HR = 2.5, 95% CI = 1.4–4.2). Conclusions: cNFL is a robust and reliable biomarker of disease activity, treatment response, and prediction of disability and conversion from RRMS to SPMS. Our data suggest that cNFL should be included in the assessment of patients at MS-onset.
An estimate of the economic burden of venous leg ulcers associated with deep venous disease
Authors: Kolluri Raghu , Lugli Marzia , Villalba Laurencia , Varcoe Ramon , Maleti Oscar , Gallardo Fernando , Black Stephen , Forgues Fannie , Lichtenberg Michael , Hinahara Jordan , Ramakrishnan Saranya , Beckman Joshua A. 
Published: August 2021

Introduction: Venous leg ulcers (VLU) embody the most severe stage of the broad spectrum of chronic venous disease. Approximately 40% of patients with VLU present with the underlying deep venous disease (DVD). Although the data are scarce, these deep venous disease-related VLU (DRV) are thought to have higher recurrence rates and a substantial economic burden. The objective of this study was to assess the economic burden of DRV across Australia, France, Germany, Italy, Spain, the UK, and the USA. Methods: A comprehensive literature review was undertaken to identify publications documenting the incidence and prevalence of VLU and DRV, medical resource utilization, and associated costs of DRV. Findings from this literature review were used to estimate the economic burden of illness, including direct medical costs over a 12-month interval following initial presentation of a newly formed DRV. Results: Total annual incidence of new or recurrent DRV in Australia, France, Germany, Italy, Spain, UK, and the US are estimated at 122,000, 263,000, 345,000, 253,000, 85,000, 230,000, and 643,000 events, respectively, in 2019. Incidence ranges from 0.73 to 3.12 per 1000 persons per year. The estimated annual direct medical costs for patients managed conservatively in these geographies total ~ $10.73 billion (USD) or $5527 per person per year. Conclusion: The availability of published data on the costs of VLU care varies widely across countries considered in this analysis. Although country-specific VLU practice patterns vary, there is a uniform pattern of high-cost care.
Association of vitamin D deficiency with clinical presentation of COVID-19
Authors: Almehmadi Mazen , Turjoman Abdullah , El-Askary Ahmad , Shafie Alaa , Rebh Fatimah , Alenazi Muhannad , Halawi Mustafa , Gharib Amal F. 
Published: August 2021

Background The coronavirus disease 2019 (COVID-19) is a respiratory virus, the spread of which has caused a global pandemic with catastrophic consequences. The current study aimed to investigate the association between vitamin D deficiency and the clinical presentation of COVID-19. Patients and methods The current study included 166 COVID-19 patients recruited from Prince Mohammad Bin Abdulaziz Hospital in Riyadh, Saudi Arabia. The study was conducted from October 2020 to January 2021. Patients were diagnosed by positive polymerase chain reaction (PCR) results. History and clinical data were collected for all subjects. In addition, laboratory analysis was done to estimate blood levels of 25 hydroxyvitamin D (25(OH)D), C-reactive protein (CRP), ferritin, parathyroid hormone (PTH), alanine aminotransferase (ALT), D-dimer, calcium, and relative lymphocytic count. COVID-19 patients were divided into three subgroups according to their vitamin D status. Patients were considered sufficient when their vitamin D level was above 30 ng/mL. Patients with vitamin D levels below 20 ng/mL were considered deficient. Patients with vitamin D levels ranging from 20 ng/mL to 30 ng/mL were considered insufficient. Results Our results showed that 81 patients (49%) were deficient in vitamin D, and 48 patients (29%) were insufficient in vitamin D. Only 37 patients (22%) had normal vitamin D levels. Moreover, a significant difference was found regarding the inflammatory markers of COVID-19 severity. Also, vitamin D levels were inversely correlated with the markers used for monitoring the condition of COVID-19 patients: ferritin, CRP, and D-dimer. Conclusion Our results showed that vitamin D deficiency was associated with increased levels of inflammatory markers of COVID-19 infection.
Can urinary biomarkers be used in the outcome assessment of pyeloplasty in children?
Authors: Keshri Rupesh , Govindarajan Krishna Kumar , Rajappa Medha , Sambandan Kumaravel , Naredi Bikash Kumar , Jindal Bibekanand 
Published: August 2021

Abstract
Background
To compare the urinary biomarkers—beta 2-microglobulin (β2M), monocyte chemotactic peptide-1 (MCP-1), and transforming growth factor-beta (TGF-β1)—in the outcome assessment of children with pelviureteric junction obstruction (PUJO) undergoing pyeloplasty.

Methods
A prospective study was conducted on children with PUJO who had pyeloplasty in a tertiary care center from July 2016 to March 2018. Urine samples were obtained from freshly voided urine samples before surgery and after 6 months of pyeloplasty. Ratio between the levels of biomarkers and urinary creatinine before and after surgery were compared.

Results
A total of 72 patients had pyeloplasty during this period. The mean levels of standardized urinary β2M, MCP-1 and TGF-β1 before surgery were 3.94 ± 4.06, 96.63 ± 117.68 and 310.65 ± 423.87, respectively, which was significantly higher than the corresponding values in the postoperative period, obtained after 6 months of surgery; postoperative mean values were 3.12 ± 3.95, 25.28 ± 32.06, 109.95 ± 118.72 (P < 0.001), respectively. Using Wilcoxon signed-rank test, fall of MCP-1 and TGF-β1 was more significant compared to β2M.

Conclusion
Urinary biomarkers (β2M, MCP-1 and TGF-β) offer an effective way of outcome assessment of pyeloplasty for PUJO in children, especially MCP-1 and TGF-β1.
Food web on ice: a pragmatic approach to investigate the trophic magnification of chemicals of concern
Authors: Kosfeld Verena , Rüdel Heinz , Schlechtriem Christian , Rauert Caren , Koschorreck Jan 
Published: August 2021

AbstractBackgroundThe trophic magnification factor (TMF) is a metric that describes the average trophic magnification of a chemical through a food web. TMFs may be used for the risk assessment of chemicals, although TMFs for single compounds can vary considerably between studies despite thorough guidance available in the literature to eliminate potential sources of error. The practical realization of a TMF investigation is quite complex and often only a few chemicals can be investigated due to low sample masses. This study evaluated whether a pragmatic approach involving the large-scale cryogenic sample preparation practices of the German Environmental Specimen Bank (ESB) is feasible. This approach could provide sufficient sample masses for a reduced set of samples allowing screenings for a broad spectrum of substances and by that enabling a systematic comparison of derived TMFs. Furthermore, it was assessed whether plausible TMFs can be derived with the ‘Food web on ice’ approach via a comparison with literature TMF values.ResultsThis investigation at Lake Templin near Potsdam is the first TMF study for a German freshwater ecosystem and aimed to derive TMFs that are appropriate for regulatory purposes. A set of 15 composite biota samples was obtained and analyzed for an extended set of benchmark chemicals such as persistent organic pollutants, mercury and perfluoroalkyl substances. TMFs were calculated for all substances that were present in > 80% of the biota samples. For example, in the case of polychlorinated biphenyls, TMFs from 1.7 to 2.5 were determined and comparisons to literature TMFs determined in other freshwater ecosystems showed similarities. We showed that 32 out of 35 compounds analyzed had TMFs significantly above 1. In the remaining three cases, the correlations were not statistically significant.ConclusionsThe derived food web samples allow for an on-demand analysis and are ready-to-use for additional investigations. Since substances with non-lipophilic accumulation properties were also included in the list of analyzed substances, we conclude that the ‘Food web on ice’ provides samples which could be used to characterize the trophic magnification potential of substances with unknown bioaccumulation properties in the future which in return could be compared directly to the benchmarking patterns provided here.
Stewardship and administrative capacity in green public procurement in the Czech Republic: evidence from a large-N survey
Authors: Plaček Michal , Valentinov Vladislav , del Campo Cristina , Vaceková Gabriela , Ochrana František , Šumpíková Markéta 
Published: August 2021

AbstractBackgroundThe uptake of green public procurement in the Czech Republic is known to lag behind the European standards. We trace this condition back to the adverse effects of a specific type of decision-making trade-off faced by the Czech public procurement officials, namely the trade-off between stewardship and administrative compliance. The trade-off means that public procurers are aware of administrative risks and complications attendant on the conscientious non-perfunctory implementation of green public procurement.ResultsThe overall result is that public procurers ultimately come to prioritize the contract criterion of the lowest price over ecological criteria. The existence of this trade-off has been generally confirmed by the results of a unique large-N survey of more than 1100 respondents from a group of local public officials and mayors in the Czech Republic.ConclusionWe have found that the decision-making of Czech public procurers is affected by the trade-off between stewardship and administrative compliance, which turn out to be mutually conflicting goals. On the one hand, many public procurers do possess a stewardship motivation that shapes their positive attitude to GPP. On the other hand, they are painfully aware of, and seek to forestall, administrative risks and complications attendant on the conscientious, i.e., non-perfunctory, implementation of GPP.
Complete genome sequence of an extensively drug resistant (XDR) M. morganii SMM01 isolated from a patient with urinary and fecal incontinence
Authors: Chanakya Pachi Pulusu , Khamari Balaram , Lama Manmath , Peketi Arun Sai Kumar , Kumar Prakash , Nagaraja Valakunja , Bulagonda Eswarappa Pradeep 
Published: August 2021

Abstract
Objective
M. morganii is a gram-negative, non-lactose fermenting and an opportunistic pathogen frequently associated with nosocomial infections. Although first isolated in 1906 from a pediatric fecal sample, not many M. morganii isolates have been sequenced. The objective of this work is to determine the complete genome sequence of an XDR M. morganii strain (SMM01) isolated from the urine of a patient with urinary and fecal incontinence and to characterize its antimicrobial resistance profile.

Data description
Here, we report the complete genome sequence of M. morganii SMM01 generated from the hybrid assembly of Illumina HiSeq X and Nanopore MinION reads. The assembly is 100% complete with genome size of 39,30,130 bp and GC content of 51%. Genomic features include 3617 CDS, 18 rRNAs, 78 tRNAs, 4 ncRNAs and 60 pseudogenes. Antimicrobial resistance profile was characterized by the presence of genes conferring resistance to aminoglycosides, β-lactams, fluoroquinolones, chloramphenicol, and tetracyclines. Secondary metabolite biosynthetic gene clusters like NRPS, T1PKS, thiopeptide, beta-lactone, and bacteriocin were identified. The genome data described here would be the first complete genome of an Indian M. morganii isolate providing crucial information on antimicrobial resistance patterns, paving the way for further comparative genome analyses.