bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased Expression of MMP17 Predicts Poor Clinical Outcomes in Epithelial Ovarian Cancer Patients
Authors: Xiao Chao , Wang Yao , Cao Chengjian 
Published: November 2021

Abstract
Objective Ovarian cancer has the highest fatality rate among female reproductive system cancers, which is due to lack of biomarkers for prognosis. We aimed to evaluate the role of MMP17 in ovarian cancer tumorigenesis and prognosis.Methods Based on the epithelial ovarian cancer (EOC) on The Cancer Genome Atlas (TCGA) database, we determined the expression of MMP17 using the Wilcoxon rank sum test. The biological functions of MMP17 were evaluated using the Metascape database and Gene Set Enrichment Analysis (GSEA). The association between MMP17 and immune cell infiltration was investigated by single sample GSEA. Logistic analysis was applied to study the correlation between MMP17expression and clinicopathological characteristics. Finally, Cox regression analysis, Kaplan–Meier analysis, and nomograms were used to determine the predictive value of MMP17 on clinical outcomes in EOC patients.Results MMP17 was much higher in EOC patients than in pericarcinous tissues (P< 0.001). MMP17-associated DEGs were significantly enriched in cell extracellular matrix (ECM) degrading and corresponding pathways in the high MMP17 expression phenotype. MMP17 has a high sensitivity and specificity for EOC diagnosis, with an area under the curve (AUC) of 0.988. MMP17 expression was found to be an independent risk factor for overall survival [Hazard Ratio(HR): 1.488, P 0.001], progression-free interval (HR: 1.347, P 0.01), and disease-specific survival (HR: 1.548, P 0.01).Conclusion Increased MMP17 expression in EOC may contribute to carcinogenesis by degrading ECM and provide diagnostic and prognostic value for clinical outcomes.
Protease-Activated Receptor-Mediated Platelet Aggregation In Patients With Type 2 Diabetes On Potent P2Y12 Inhibitors
Authors: Panzer Benjamin , Wadowski Patricia P , Huber Kurt , Panzer Simon , Gremmel Thomas 
Published: November 2021

Abstract
Background: Dual antiplatelet therapy is a cornerstone in the secondary prevention of ischemic events following percutaneous coronary intervention (PCI) with stent implantation. The new, more potent adenosine diphosphate (ADP) P2Y12 receptor inhibitors prasugrel and ticagrelor have been shown to improve patients’ outcomes. Whether or not these drugs have equal efficacy in diabetic as in non-diabetic individuals is disputed. Furthermore, platelets can be activated by thrombin, which is, at least in part, independent of ADP-inducible activation. Protease-activated receptor (PAR)-1 and -4 are thrombin receptors on human platelets activated by the agonists SFLLRN and AYPGKF, respectively. In the current study, we sought to compare the in vitro efficacy of prasugrel (n=121) and ticagrelor (n=99) to inhibit PAR-mediated platelet activation in patients with type 2 diabetes (n=55).Materials and Methods: We compared P2Y12-, PAR-1- and PAR-4-mediated platelet aggregation as assessed by multiple electrode platelet aggregometry between prasugrel- and ticagrelor-treated patients without and with type 2 diabetes who underwent acute PCI. Results: There were no significant differences of on-treatment platelet aggregation in response to ADP, SFLLRN and AYPGKF between patients on prasugrel or on ticagrelor. Diabetic and non-diabetic patients responded equally. There was no significant correlation between either; ADP-, SFLLRN-, or AYPGKF-inducible platelet aggregation and levels of HbA1c or the body mass index. However, we observed patients with high residual platelet reactivity to SFLLRN and AYPGKF in all cohorts.Conclusion: Prasugrel and ticagrelor inhibit platelet aggregation in diabetic and non-diabetic patients to a similar extent.
A Efficient System based on Model Segmentation for Weld Seam Grinding Robot
Authors: Ge Jimin , Deng Zhaohui , Li Zhongyang , Li Wei , Liu Tao , Zhang Hua , Nie Jiaxu 
Published: November 2021

Abstract
Uneven surface quality often occurs when butt welds are manually grinding, so robotic weld grinding automation has become a fast-developing trend. Weld seam extraction and trajectory planning are important for automatic control of grinding process. However, most of the research on weld extraction is focused on before welding. Due to the irregular shape of the weld after welding, and too little work has been devoted to the weld identification after welding. Consequently, in this paper, a novel simple and efficient weld extraction algorithm is proposed, and the robot grinding path is planned. Firstly, a new flexible bracket structure for welding seam extraction is designed. Secondly, the weld seam section profile model is established, and the processing of spatial point cloud problem is transformed into the processing of two-dimensional point cloud problem. The least square method (LSM) based on threshold comparison is used to segment the weld seam, which greatly improved the processing speed and accuracy. Then the grinding path and pose are obtained according to the extracted weld space structure. Finally, a robotic welding seam automatic grinding system is built. Experiments show that the proposed method could well extract the irregular weld contour after welding and the grinding system built is reliable, which greatly improves the grinding efficiency.
Gravitational Fields and Gravitational Waves
Authors: Yuan Tony 
Published: November 2021

Abstract
The relative velocity between objects with finite velocity affects the reaction between them. This effect is known as general Doppler effect. The Laser Interferometer Gravitational-Wave Observatory (LIGO) discovered gravitational waves and found their speed to be equal to the speed of light c. Gravitational waves are generated following a disturbance in the gravitational field; they affect the gravitational force on an object. Just as light waves are subject to the Doppler effect, so are gravitational waves. This article explores the following research questions concerning gravitational waves: What is the spatial distribution of gravitational waves? Can the speed of a gravitational wave represent the speed of the gravitational field (the speed of the action of the gravitational field upon the object)? What is the speed of the gravitational field? Do gravitational waves caused by the revolution of the sun affect planetary precession? Can we modify Newton’s gravitational equation through the influence of gravitational waves?
Gender-specific associations of pregnancy-related anxiety with placental epigenetic patterning of glucocorticoid response genes and preschooler’s emotional symptoms and hyperactivity
Authors: Liu Hui , Liu Yuwei , Huang Kun , Yan Shuangqin , Hao Jiahu , Zhu Peng , Tao Fangbiao , Shao Shanshan 
Published: November 2021

Abstract
Backgroud: We have recently reported that maternal prenatal pregnancy-related anxiety predicts preschoolers’ emotional and behavioral development in a gender-dependent manner. This study aims to test for this gender-specific effect in a different cohort and investigate whether the gender difference was specific to placental methylation of genes regulating glucocorticoids.Methods: A total of 2405 mother–child pairs from the Ma’anshan Birth Cohort Study were included in present study. The maternal pregnancy-related anxiety symptoms were evaluated with the Pregnancy-Related Anxiety Questionnaire in the third trimester of pregnancy. Child neurobehavior was assessed with the Strengths and Difficulties Questionnaire at 4 years old. Placental methylation of FKBP5, NR3C1 and HSD11B2 genes was quantified using the MethylTarget approach in 439 pregnant women. After exploratory factor analysis, the associations between methylation factor scores and pregnancy-related anxiety and child neurobehavior were examined using logistic regression analysis.Results: After controlling for confounding factors, pregnancy-related anxiety in the third trimester of pregnancy increased the risk of hyperactivity only in boys and emotional symptoms only in girls. Decreased scores of the factor characterized by FKBP5 methylation were associated with maternal pregnancy-related anxiety only in boys. Furthermore, increased scores of the factors characterized by NR3C1 and HSD11B2 methylation were associated with hyperactivity (NR3C1: adjusted OR = 1.80, 95 %CI = 1.15–2.83) and emotional symptoms (HSD11B2: adjusted OR = 0.53, 95 %CI = 0.29–0.97; NR3C1: adjusted OR = 1.64, 95 %CI = 1.03–2.59) only in boys. However, the scores of the factor characterized by FKBP5, NR3C1 and HSD11B2 did not mediate the relationship between maternal pregnancy-related anxiety and preschoolers’ emotional symptoms and hyperactivity.Conclusions: Our results suggested that pregnancy-related anxiety in the third trimester of pregnancy predicted preschoolers’ emotional symptoms and hyperactivity in a gender-dependent manner. Although we did not find the mediation role of the placental methylation of genes regulating glucocorticoids, we found it was associated with both maternal pregnancy-related anxiety and preschoolers’ emotional symptoms and hyperactivity in a gender-dependent manner.
Postoperative Outcomes in Exploratory Laparotomy and Intestinal Resection in Children: A Secondary Descriptive Observational Analysis
Authors: Kumba Claudine 
Published: November 2021

Abstract
Background: We previously reported independent predictors of intraoperative and postoperative morbidity. These were age, American Society of Anesthesiologists Score (ASA), emergency situations, surgery and transfusion. ASA was the independent predictor of mortality. We conducted a secondary analysis of this previous retrospective study in patients who underwent exploratory laparotomy and intestinal resection.Objectives: To describe intraoperative and postoperative outcomes in patients who underwent exploratory laparotomy and intestinal resection in the initial study and to present a research protocol for intraoperative and postoperative optimization.Methods: Secondary analysis of the initial study. The Ethics Committee approved the study.Results: There were 54 patients with a median age of 15.5[0-172] months. Thirty-seven (68.5%) patients underwent intestinal resection, nine (16.7%) underwent exploratory laparotomy, and eight (16.8%) underwent laparotomy for volvulus.Fourteen (25.9%) patients had intraoperative and/or postoperative complications. Two (3.7%) patients had intraoperative hemorrhagic shock. Two (3.7%) patients had postoperative cardio-circulatory failure. Three (5.6%) had postoperative respiratory failure. One (1.8%) patient had postoperative multiple organ failure and neurologic failure. Three (5.6%) patients had postoperative abdominal sepsis. One (1.8%) patient had postoperative multiple organ sepsis and neuromeningeal sepsis. Four (7.4%) patients had postoperative pulmonary sepsis. Two (3.7%) had postoperative septicemia. Six (11.1%) patients had reoperations. Seventeen (31.5%) patients had intraoperative transfusion.The in-hospital mortality rate was 3.7% in two patients.Conclusion: The number of patients with postoperative complications in this cohort was not negligible. We therefore elaborated a research protocol where intraoperative patient management will be guided with transthoracic echocardiography for fluid and hemodynamic therapy optimization. The objectives of this study protocol are to clarify the impact of intraoperative goal-directed fluid and hemodynamic therapy with transthoracic echocardiography on postoperative outcomes in terms of complications in pediatric surgical patients.
Heron’s cubic root iteration method with a new approach
Authors: Gadtia S. , Padhan S. K. 
Published: November 2021

Abstract
Heron’s cubic root iteration formula conjectured by Wertheim is proved and extended for any odd order roots. Some possible proofs are suggested for the roots of even order. An alternative proof of Heron’s general cubic root iterative method is explained. Further, Lagrange’s interpolation formula for nth root of a number is studied and found that Al-Samawal’s and Lagrange’s method are equivalent. Again, counterexamples are discussed to justify the effectiveness of the present investigations.
Comparative Analysis of Rainfall Trends in the Jinghe River Basin of China During 1959-2014
Authors: Weng Xuerou , Long Xunjian , Ye Yan , Ye Yong 
Published: November 2021

Abstract
Trend analysis is widely applied in hydrometeorological research. Considering that Innovative Trend Analysis (ITA) and Innovative Polygonal Trend Analysis (IPTA) can detect small variations on annual and smaller scale, rainfall trends at 14 hydrometeorological stations in the Jinghe River Basin were analyzed by ITA, IPTA and Mann Kendall test (MK). The results showed that the rainfall trends are subsistent from 1959 to 2014. Comparing the results of ITA and MK on annual level, it was determined that trends are consistent, but only two stations passed the 90% significance test through MK, while all stations passed the significance test through ITA. Accordingly, the ITA method proved to be better than MK in detecting small changes in time series. Changes in high and low values, obtained by the ITA method, reflected flood and drought trends in the basin. In addition, IPTA is an improved ITA method that is suitable for a relatively short time span. Through the IPTA method for analyzing the monthly precipitation trends, the results showed that rainfall at 14 stations increased in January, February, March, June and December, and decreased significantly in September. Therefore, the methodology applied in this study can provide detailed recommendations for hydrometeorological research.
An Algorithm of Mobile Edge Computing Offloading Based on Improved SPEA2 Algorithm
Authors: Ye Dan , Wang Xiaogang , Hou Jin 
Published: November 2021

Abstract
Internet of things devices can offload some tasks to the edge servers through the wireless network, thus the computing pressure and energy consumption are reduced. But this will increase the cost of communication. Therefore, it is necessary to maintain the balance between task execution energy and experiment when designing the offloading strategy for the edge computing scenario of the Internet of things. This paper proposes an offloading strategy which can optimize the energy consumption and time delay of task execution at the same time. This strategy satisfies different preferences of users. First, the above task is modeled as a multi-objective optimization problem, and the Pareto solution set is found by improving the strength Pareto evolutionary algorithm (SPEA2). Based on the Pareto set, the offloading strategy satisfying the requires of users with different preferences by offloading cost estimation. Second, a simulation experiment is carried out to verify the robustness of the improved SPEA2 algorithm under the influence of different main parameters. By comparing with other algorithms. It is proved that the improved SPEA2 algorithm can minimize the balance between task execution delay and energy consumption.
Thymic Stromal Lymphopoietin Is Associated With Disease Activity in Systemic Lupus Erythematosus
Authors: Lai Xiaofei , Yang Huiqing , Ding Hao , Cao Ju 
Published: November 2021

Abstract
Objective To investigate the association between Thymic stromal lymphopoietin (TSLP) and disease activity in patients with Systemic Lupus Erythematosus (SLE).Methods In this study, concentrations of serum TSLP in 65 SLE patients, 50 sex and age-matched control subjects were determined by enzyme-linked immunosorbent assay (ELISA).Results Serum TSLP concentrations in SLE patients were dramatically higher than healthy controls. The levels of serum TSLP displayed a significant increase as compared with healthy controls. More importantly, TSLP levels were significantly correlated with SLE disease activity features such as ESR, CRP, Anti-dsDNA Ab, and SLEDAI-2K,. The predictive value of TSLP on high disease activity was superior to those of CRP, ESR, and Anti-dsDNA Ab. A note worthy correlation in our study was observed between the serum TSLP levels and laboratory parameters, particularly serum lipids. Furthermore, serum TSLP levels could be significantly down-regulated after effective integrative treatment.Conclusion TSLP may serve as a novel sensitive biomarker to assist disease activity assessment and monitor therapeutic effects in active SLE patients.
Analysis of Spatially Varying Relationships Between Urban Environment Factors And Land Surface Temperature In Mashhad City, Iran
Authors: Soltanifard Hadi , Kashki Abdolreza , Karami Mokhtar 
Published: November 2021

Abstract
Land Surface Temperature (LST), in particular for the urban environment, is a key indicator to characterize urban heat changes, urban climate, global environmental change, and human-environment interactions. However, due to differences in the local spatial variations of LST and the related influence factors, few studies have discussed the spatial non-stationarity and spatial scale effects within urban areas. Moreover, in cities such as Mashhad, which are located in a hot and dry climate, have been less studied of the relationship between LST and urban influencing factors on a neighborhood scale. In the present study, the spatial distribution of the mean LST was evaluated in association with the 16 explanatory indices at the neighborhood's level in Mashhad City, Iran, as a case study. To assess the main components contributing to the LST variations, Principal Components Analysis (PCA) was employed in this study. Additionally, Ordinary Least Square (OLS) and Geographically Weighted Regression (GWR) models were used to explore the spatially varying relationships and identify the model's efficiency at the neighborhood's scale. Our findings showed the five most important components contributing to LST variances, explaining 86.2% of the variability. The most negative relationship was observed between LST and the morphological features of neighborhoods (PC3). In contrast, the landscape composition of the green patches (PC2) exhibited the lowest negative impacts on LST changes. Moreover, road and traffic density characteristics of the neighborhoods (PC4) were the only effective components to alert the average LST positively. With R2= 0.678, AIC c= 2125.6, and Moran's I= 0.018, the results revealed that the GWR model had better efficiency than the corresponding non-spatial OLS model in terms of the goodness of fits. It suggests that the GWR model has more ability than the OLS one to predict LST intensities and characterize spatial non-stationary. Therefore, it can be applied to adapt more effective strategies in planning and designing the urban neighborhoods for mitigation of the adverse heat effects.
Mosquito control, killing off the females.
Authors: Tran Phi 
Published: November 2021

Abstract
In addition to causing discomfort, female mosquitoes introduce disease-carrying viruses and bacteria into the bloodstream of their victims. There are numerous publications describing the uses of sugary mosquito baits with promising results. Without temperature control measures however, these methods are mainly useful for only nectar-feeding insects, including male mosquitoes, because the warmth of the blood is a condition for the females to locate their meals. The efforts required to keep the baits fresh against the natural spoiling process make them less attractive or impractical to implement. These experiments address these issues by using warm baits of water, sugar, boric acid, and antibiotics. Overnight, the general areas became clear of blood-sucking female mosquitoes while in numbers, the harmless males concentrated into the immediate vicinities. Control vs. experiment protocol established no other logical explanation for this phenomenon other than that the females were attracted and killed by the bait. As expected, there was no mosquito egg-laying activity in these areas.
miR-144-3p Regulates Vascular Smooth Muscle Cell Phenotypic Switch via FBN1
Authors: Lin Aiqi , Kang Xiaocui , Jiao Yuqiong , Feng Xiaochao , Xu Yi , Yan Wei , Li Yao , Han Xiang , Dong Qiang 
Published: November 2021

Abstract
Background: Carotid artery dissection (CAD) represents a commonly reported factor causing stroke in young and middle-aged adults. Vascular wall remodeling is one of its important pathogenetic mechanisms. FBN1 is a common pathogenic gene leading to Marfan syndrome, whose mutation can cause the formation of aneurysm and arterial dissection. It was recently demonstrated multiple miRNAs contribute to the development of arterial dissection, while miR-144-3p’s function is undefined.Methods: In the current study, vascular smooth muscle cells (VSMCs) were transfected with miR-144-3p mimic and inhibitor, as well as siFBN1 and miR-144-3p + siFBN1, to determine vascular smooth muscle’s contractile genes, extracellular matrix-associated proteins. In addition, miR-144-3p’s effects on cell proliferation, migration, adhesion, invasion and apoptosis were evaluated.Results: The results revealed miR-144-3p had elevated amounts, while the fibrillin-1 protein showed reduced expression in arterial dissection tissues. Meanwhile, FBN1 was shown to be a miR-144-3p target by dual-luciferase gene reporter assay. In response to miR-144-3p mimic transfection, decreased expression of VSMC contractile gene markers, increased apoptosis, and decreased proliferation, migration, and invasion were found.Conclusions: Overall, miR-144-3p affects the biological function of VSMCs by targeting and regulating FBN1, decreases the expression of contractile genes，transforms the phenotype and leads to vascular wall remodeling.