bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of a new nursing diagnosis: Perioperative thirst
Authors: Alves do Nascimento Leonel , de Oliveira Lopes Marcos Venicius , Fahl Fonseca Ligia 
Published: March 2021

AbstractPurposeTo develop and validate the content of the nursing diagnosis proposal for perioperative thirst.MethodsA content analysis by 34 judges. An online Delphi panel was used in one round, evaluating criteria of relevance, clarity and precision. Wilcoxon's one‐tailed test was used and the content validity index to maintain the item was set to 0.80.FindingsThe content validity index in relation to the evaluated items reached levels between 0.87–1.00. The final components of the diagnosis proposal included the following items as defining characteristics: dry mouth, dry throat, dry lips, thick saliva, thick tongue, constant swallowing of saliva, desire to drink water, bad taste in the mouth, and caregiver's report. Related factors are as follows: pre‐ and postoperative fasting, oral breathing, dehydration, hypovolemia, insensitive loss of hydration by breathing, dry mouth, habit of drinking water, high room temperature. Associated conditions: intubation, use of muscarinic and nicotinic anticholinergics and water restriction.ConclusionsAll components of the nursing diagnosis were validated in relation to relevance, clarity, and accuracy, demonstrating high levels of agreement between experts. Qualitative observations were found to be fundamental for both combining and excluding some items.Implications for Nursing PracticeImprovement of refinement and clarity levels of this nursing diagnosis proposal aiding its inclusion in the NANDA International taxonomy and thus enabling greater understanding of the phenomenon of thirst in surgical patients. This study helps to explain and facilitate the identification of defining characteristics, related factors, and associated conditions for nurses, nursing students, and researchers on this subject.
miR‐425 regulates ovarian cancer proliferation, metastasis, and apoptosis by repressing PAK4 expression
Authors: Wang Yichen , Shao Feng , Chen Lu 
Published: March 2021

AbstractAimTo explore the biological function of miR‐425/PAK4 axis in proliferation, metastasis, and apoptosis of ovarian cancer (OC) cells.MethodsqRT‐PCR and Western blot were adopted to examine miR‐425 and PAK4 expressions in OC tissues and cell lines. Cell counting kit‐8 (CCK‐8) and BrdU assays were applied to detect the proliferation ability of OC cells, and Transwell assay was adopted to assess the migration and invasion of OC cells. Flow cytometry was employed to evaluate the apoptosis of OC cells. The interaction between miR‐425 and PAK4 was predicted and verified by bioinformatics analysis and dual luciferase reporter gene assay, respectively.ResultsmiR‐425 was reduced in OC tissues and cell lines, and its underexpression was in evident correlation with the shorter overall survival time of OC patients. miR‐425 impeded OC cell proliferation, migration, and invasion, and accelerated apoptosis. Additionally, PAK4 was validated as the target of miR‐425, and the cotransfection of PAK4 reversed the antitumor effect of miR‐425.ConclusionmiR‐425 suppresses the proliferation, migration, and invasion of OC cells and enhances apoptosis via inhibiting PAK4, and it is expected to be a prognostic indicator and therapeutic target for the patients with OC.
Incidence and mortality rates of lung cancer in Qingdao, China (2013‐2017)
Authors: Sun Xiaohui , Xu Xiang , Wang Yumei , Hou Binghui , Luo Tingting , Meng Di , Wang Shaojie , Ning Feng 
Published: March 2021

AbstractAimsTo analyze lung cancer incidence and mortality rates from 2013 to 2017 in Qingdao, Shandong Province, China.MethodsThe lung cancer new cases and death data during 2013‐2017 were collected from the Qingdao Cancer Surveillance System. The crude incidence and mortality rates were calculated by residential area and gender. The annual percentage change (APC) was determined to evaluate the incidence and mortality rate trends.ResultsBetween 2013 and 2017, 31 653 new lung cancer cases and 24 965 deaths from lung cancer were retrieved. The age‐standardized incidence rates by Chinese standard population (ASIRC) were 42.1 per 100 000. The crude incidence rates for men and women increased from 85.2 and 46.3 per 100 000 in 2013 to 124.0 and 67.4 per 100 000 in 2017, respectively. The APCs were 7.8% for men (P < .001) and 7.5% (P = .027) for women. The crude mortality rates increased from 56.3 per 100 000 in 2013 to 68.0 per 100 000 in 2017. The age‐standardized mortality rates by ASIRC were 32.3 per 100 000. The APCs of mortality rates were higher in men than in women and were higher in rural than in urban areas. Age‐specific incidence and mortality rates were lower in individuals aged <40 years, increased sharply in those aged >40 years, and were the highest in 80‐year‐old individuals.ConclusionThese data show different patterns of incidence and mortality rate according to gender and resident area during 2013‐2017. Early screening and targeted prevention should be implemented to control the increased trend of lung cancer.
Quality of life and sexual function after a pregnancy complicated by placenta accreta spectrum
Authors: Bartels Helena C. , Terlizzi Kristen , Cooney Naomi , Kranidi Athina , Cronin Martina , Lalor Joan G. , Brennan Donal J. 
Published: March 2021

Background and AimsLittle is known about the impact of Placenta Accreta Spectrum (PAS) on quality of life (QoL). This study aims to explore QoL and sexual function after a pregnancy complicated by PAS.MethodsWomen who experienced a pregnancy complicated by PAS were invited to complete an online survey. Two validated surveys were completed: Short Form 36 (SF‐36) and Female Sexual Function Index (FSFI). The mean scores were calculated and were compared between women by pregnancy outcomes. Continuous variables were presented as mean (standard deviation (SD)) and were compared to assess for significance between groups using independent t‐test and one‐way analysis of variance. Categorical variables were compared using χ2 test.ResultsA total of 142 women responded to the survey. For the SF‐36, physical health was significantly higher for women at 24–36 months postpartum compared to those from 0–6 months postpartum for physical functioning (mean difference 21.9 (95% confidence interval (CI) 10.2, 33.5), role limitation due to physical function (mean difference 32.1 (95% CI 9.4, 54.7)) and pain (mean difference 15.5 (95% CI 3.4, 30.9)). For the mental health domains, only vitality improved at 24–36 months compared to the first six months postpartum (mean difference 12.8 (95% CI 0.2, 25.5)). The mean FSFI score was 24.8 (±5.8), lower than the critical score of 26.5 indicating sexual dysfunction, and 56.8% (n = 75), scored less than 26.5.ConclusionWomen after a pregnancy complicated by PAS had high scores on the physical health domains of SF‐36. The mental health scores were lower for all women regardless of time since birth.
Welfare assessment in intensive and semi‐intensive dairy cattle management system in Sicily
Authors: Pugliese Michela , Biondi Vito , Passantino Annamaria , Licitra Francesca , Alibrandi Angela , Zanghi Antonina , Conte Francesca , Marino Gabriele 
Published: March 2021

AbstractThe present study aimed to compare the welfare of dairy cows kept in two traditional husbandry systems (semi‐intensive and intensive farming) in south‐eastern Sicily. A total of 18 dairy farms (nine semi‐intensive and nine intensive) were evaluated with a multicriteria system adapted for Sicilian conditions and obtained simplifying the model of the European Food Safety Authority (EFSA). Values of welfare measures, collected by inspections of the farms (general well‐being indicators, ventilation system, resting areas [cubicles or bedding], flooring, milking parlours and waiting area, manger and watering equipment), and those of health categories (cases of abortions, hypocalcemia, displacement of abomasum, acidosis/ketosis, enteritis, hoof problems, and mastitis) obtained through the farm records, were compared using Mann–Whitney and Chi‐squared tests, respectively. Data showed significant differences (p ≤ .05) about the variables related to welfare categories such as housing ventilation system, resting area, manger, and water equipment that were better in the semi‐intensive system than the intensive system. No significant differences were observed about the variables related to health indicators. The results demonstrated that in Sicily the semi‐intensive farm is better than the intensive to satisfy the conditions of animal welfare.
Barriers to employment as experienced by disabled university graduates in Yogyakarta, Indonesia
Authors: Lessy Zulkipli , Kailani Najib , Jahidin Asep 
Published: March 2021

AbstractBecause of experiencing discrimination, denial, stress, and rejection from prospective employers, disabled university graduates struggle to find jobs. By interviewing eight participants and conducting a focus group discussion with them at Sunan Kalijaga State Islamic University Yogyakarta, the findings revealed that the teaching procedures in larger inclusive classrooms seemed to be a barrier for most disabled university students. Consequently, the students needed vocational training in addition to their courses before integrating into the workforce. Recalling when being students, these disabled university graduates found it difficult to prepare for jobs that required math or science because their university courses had not included assistance with different kinds of media. Additionally, they did not feel prepared for writing curriculum vitae and preparing job applications. They indicated that the university setting did not prepare them to deal with the typically fierce competition in job markets. They also found getting a job in the labor market to be difficult because a scarcity of formal employment opportunities suitable to their fields, and employers do not provide feedback or even any reply at all, to their job applications. In summary, academic, social, cultural, economic, psychological barriers, and discriminatory practices were encountered for disabled university graduates seeking employment.
Effects of a physician‐ and pharmacist‐managed clinic on pain management in cancer patients in China
Authors: Liu Keke , Huang Hangxing , Zhang Lu , Huang Yamin , Sun Shusen , Chen Xiaoping , Chen Yao , Liu Wenhui , Xiao Jian 
Published: March 2021

AbstractIn China, pharmacists have started to manage cancer pain at outpatient clinics. This retrospective study performed at a tertiary teaching hospital was aimed to evaluate the effects of a physician‐pharmacist joint clinic for cancer pain management. The study was performed between December 2016 and August 2019 and included 113 outpatients with moderate to severe cancer‐related pain. Patients were divided into two groups according to the clinic each patient visited: the physician‐pharmacist joint clinic (joint group, n = 59) or physician‐only clinic (usual group, n = 54). Brief Pain Inventory (BPI) and Morisky Medication Adherence Measure (MMAM) were used to collect data on pain intensity, interference and medication adherence. Pain Management Index (PMI) was also calculated. BPI, MMAM and PMI were assessed at baseline (patients’ first visit, week 0) and week 4 follow‐up. The Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire‐Core 30 (EORTC QLQ‐C30) was used to assess patients’ health‐related quality of life (HRQoL) at week 4. The primary outcomes were the improvement in pain intensity, adequacy of pain management and medication adherence. The secondary outcome was the improvement in HRQoL. At week 4, compared to the usual group, the BPI pain intensity categories except the pain right now were significantly lower in the joint group: worst pain, 4 (3‐7) vs 6 (4‐8), P = .020; least pain, 1 (0‐2) vs 2 (1‐3), P = .010; average pain, 3 (2‐4) vs 4 (2‐5), P = .023; pain right now, 2 (1‐3) vs 2 (0‐4), P = .796. For the seven pain interference categories, there were no significant improvements in the joint group (P > .05). Significantly more patients achieved adequate pain control in the joint group than the usual group ((P = .002). There was also a significant difference in medication adherence between the two groups (P = .001). There were no significant differences in HRQoL between the two groups. The study suggests that pharmacist participation in outpatient cancer pain management is associated with improvement of patients' pain control and medication adherence.
Distinct bone marrow immunophenotypic features define the splicing factor 3B subunit 1 (SF3B1)‐mutant myelodysplastic syndromes subtype
Authors: Duetz Carolien , Westers Theresia M. , in ’t Hout Florentien E. M. , Cremers Eline M. P. , Alhan Canan , Venniker‐Punt Bianca , Visser‐Wisselaar Heleen A. , Chitu Dana A. , de Graaf Aniek O. , Smit Linda , Jansen Joop H. , van de Loosdrecht Arjan A. 
Published: March 2021

SummarySplicing factor 3B subunit 1 (SF3B1) mutations define a distinct myelodysplastic syndromes (MDS) patient group with a relatively favourable disease course and high response rates to luspatercept. Few data are available on bone marrow phenotype beyond ring sideroblasts in this subgroup of patients with MDS. In the present study, we identified immunophenotypic erythroid, myelomonocyte and progenitor features associated with SF3B1 mutations. In addition, we illustrate that SF3B1‐mutation type is associated with distinct immunophenotypic features, and show the impact of co‐occurrence of a SF3B1 mutation and a deletion of chromosome 5q on bone marrow immunophenotype. These genotype–phenotype associations and phenotypic subtypes within SF3B1‐MDS provide leads that may further refine prognostication and therapeutic strategies for this particular MDS subgroup.
Compliance without fear: Individual‐level protective behaviour during the first wave of the COVID‐19 pandemic
Authors: Jørgensen Frederik , Bor Alexander , Petersen Michael Bang 
Published: March 2021

ObjectivesThe outbreak of the COVID‐19 pandemic required rapid public compliance with advice from health authorities. Here, we ask who was most likely to do so during the first wave of the pandemic.DesignQuota‐sampled cross‐sectional and panel data from eight Western democracies (Denmark, France, Germany, Hungary, Italy, Sweden, the United Kingdom, and the United States).MethodsWe fielded online public opinion surveys to 26,508 citizens between 19 March and 16 May. The surveys included questions about protective behaviour, perceptions of the pandemic (threat and self‐efficacy), as well as broader attitudes towards society (institutional and interpersonal trust). We employ multilevel and fixed‐effects regression models to analyse the relationship between these variables.ResultsConsistent with prior research on epidemics, perceptions of threat turn out as culturally uniform determinants of both avoidant and preventive forms of protective behaviour. On this basis, authorities could foster compliance by appealing to fear of COVID‐19, but there may be normative and practical limits to such a strategy. Instead, we find that another major source of compliance is a sense of self‐efficacy. Using individual‐level panel data, we find evidence that self‐efficacy is amendable to change and exerts an effect on protective behaviour. Furthermore, the effects of fear are small among those who feel efficacious, creating a path to compliance without fear. In contrast, two other major candidates for facilitating compliance from the social sciences, interpersonal trust and institutional trust, have surprisingly little motivational power during the first wave of the COVID‐19 pandemic.ConclusionsTo address future waves of the pandemic, health authorities should thus focus on facilitating self‐efficacy in the public.
On the floristic identity of Amazonian vegetation types
Authors: Oliveira‐Filho Ary T. , Dexter Kyle G. , Pennington R. Toby , Simon Marcelo F. , Bueno Marcelo L. , Neves Danilo M. 
Published: March 2021

AbstractThe Amazon forest is far from uniform, containing different forest types and even savannas, but quantitative analyses of this variation are lacking. Here, we applied ordination analyses to test the floristic differentiation among Amazonian vegetation types using data for virtually all known tree species occurring in the Amazon (8224), distributed across 1584 sites. We also performed multiple regressions to assess the role of climate and substrate in shaping continental‐scale patterns of community composition across Amazonia. We find that the traditional classification of Amazonian vegetation types is consistent with quantitative patterns of tree species composition. High elevation and the extremes of substrate‐related factors underpin the floristic segregation of environmentally “marginal” vegetation types and terra firme forests with climatic factors being relatively unimportant. These patterns hold at continental scales, with sites of similar vegetation types showing higher similarity between them regardless of geographic distance, which contrasts with the idea of large‐scale variation among geographic regions (e.g., between the Guiana Shield and southwestern Amazon) representing the dominant floristic pattern in the Amazon. In contrast to other tropical biomes in South America, including the Mata Atlântica (second largest rain forest biome in the neotropics), the main floristic units in the Amazon are not geographically separated, but are edaphically driven and spatially interdigitated across Amazonia. Two thirds of terra firme tree species are restricted to this vegetation type, while among marginal vegetation types, only white‐sand forests (campinaranas) have a substantial proportion of restricted species, with other vegetation types sharing large numbers of species.
Turning 18 in specialised residential therapeutic care: Independence or a cliff edge?
Authors: Field Alice , Sen Robin , Johnston Claire , Ellis Katie 
Published: March 2021

AbstractThis article describes research undertaken in 2018 in a therapeutic residential home for young women with multiple and complex needs in out‐of‐home care in England. Based on qualitative interviews with five young women, aged 16–18, and four professionals working with the home, the article analyses the under‐researched leaving care needs and experiences of this group of young women. The findings highlight the tensions between notions of childhood and expectations of adulthood surrounding this group of young people. These converge around reaching the age of 18 and foreground vulnerability on the one side, and responsibility on the other.
Contact sensitizations to disinfectants containing alcohols or quaternary ammonium compounds are rarely of clinical relevance
Authors: Kreipe Katharina , Forkel Susann , Heinemann Kim‐Elisabeth , Amschler Katharina , Fuchs Thomas , Geier Johannes , Buhl Timo 
Published: March 2021

AbstractBackgroundThe use of disinfectants is part of the everyday life of people, especially in the medical profession. During the coronavirus disease 2019 (COVID‐19) pandemic, the use of disinfectants continues to increase and is of fundamental importance in infection control.ObjectivesTo determine the frequency of sensitization and the value of patch testing to didecyldimethylammonium chloride (DDAC) and the alcohols ethanol, 1‐propanol, and isopropanol.MethodsClinical patch test data of 145 patients with suspected contact allergy to disinfectants were retrospective analysed.ResultsAmong the 145 patients patch tested with the different alcohols, only one nurse was detected with a possible allergy to 1‐propanol. Additional patch testing in 84 patients with DDAC 0.05% resulted in five patients with weakly positive reactions only, without clinical relevance. Patch testing with DDAC 0.03% showed no positive reactions at all on day 3 readings.ConclusionsDDAC and alcohols are rarely responsible for allergic contact dermatitis. The accused products of the patients should be checked for other allergens and further additives with skin‐irritating properties. Individual susceptibility and mishandling of the disinfectants should be considered.
Ecosystem integrity is neither real nor valuable
Authors: Rohwer Yasha , Marris Emma 
Published: March 2021

AbstractWe argue that “ecological integrity” is a bad fit as a value for conservation biology and restoration ecology. Both fields are organized around shared values, but it is important to be clear about the specific values and reasons motivating protection of or interventions in specific ecosystems. In practice, appeals to ecological integrity often fail to account for losses in value when ecosystems change. Ultimately, we do not believe ecosystems are the kinds of things that have integrity. Ecosystems are simply too dynamic in space and time, their complex interconnections, including coevolved relationships, ultimately fleeting at the geological scale. Any impression of “wholeness” is an artifact of the brevity of human lives and the shallowness of our historical records. We believe “ecological integrity” as it is currently used is typically a proxy for the values of diversity, complexity, and cultural connections with beloved ecosystem states. We should simply say what we mean and retire the concept of “ecological integrity.”
The Re‐making of the Turkish Crisis
Authors: Orhangazi Özgür , Yeldan A. Erinç 
Published: March 2021

ABSTRACTBy the end of 2018 Turkey had entered a new economic crisis and a lengthy recession period. In contrast to the previous financial crises of 1994, 2001 and 2009, when the economy shrank abruptly with a spectacular collapse of asset values and a severe contraction of output, the 2018 economic crisis was characterized by a prolonged recession with persistent low (negative) rates of growth, dwindling investment performance, debt repayment problems, secularly rising unemployment, spiralling currency depreciation and high inflation. The mainstream approach attributes this dismal performance to a lack of ‘structural reforms’ and/or exogenous policy factors. However, this analysis shows that the underlying sources of the crisis are to be found not in the conjunctural cycles of reform fatigue, but rather in the post‐2001, neoliberal, speculation‐led growth model that relied excessively on hot‐money inflows and external debt accumulation. This article argues that following the post‐2001 orthodox reforms, a foreign capital inflow‐dependent, debt‐led and construction‐centred economic growth model dominated the economy and caused a long build‐up of imbalances and increased fragilities that led to the 2018 crisis. The Covid‐19 pandemic of 2020‒21 further exposed these fragilities, pushing the economy back into a recession with rapid capital outflows causing another round of sharp currency depreciation.