bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility and Outcomes of ERAS Protocol in Elective cT4 colorectal Cancer Patients. Results from a Single Center Retrospective Cohort Study.
Authors: Bellato Vittoria , An Yongbo , Cerbo daniele , Campanelli Michela , Franceschilli Marzia , Khanna krishn , Sensi Bruno , Siragusa Leandro , Rossi piero , Sica Giuseppe 
Published: April 2021

Abstract
BACKGROUND: Programs of Enhanced Recovery After Surgery reduces morbidity and shorten recovery in patients undergoing colorectal resections for cancer. Patients presenting with more advanced disease such as T4 cancers, are frequently excluded from undergoing ERAS programs due to the difficulty in applying the whole or part of established protocols. The primary aim of this investigation was to evaluate the possibility of applying a validated ERAS protocol in patients undergoing colorectal resection for T4 colon and rectal cancer and to evaluate the short-term outcome.METHODS: Single center, retrospective cohort study. All patients with a clinical diagnosis of stage T4 colorectal cancer undergoing surgery between November 2016 to January 2020 were treated following the institutional fast track protocol without exclusion. Short-term postoperative outcomes were compared to those of a control group treated with conventional care and that underwent surgical resection for T4 colorectal cancer at the same institution from January 2010 to October 2016. Data from both groups were collected retrospectively from a prospectively maintained database. RESULTS: Eighty-two patients were diagnosed with T4 cancer, 49 patients were included in the ERAS cohort and 33 in the historical conventional care cohort. Both, the mean time of tolerance to solid food diet and postoperative length of stay, were significantly shorter in the ERAS group than in the control group (3.14±1,76 vs 4.8±1.52; p<0,0001 and 6,93±3,76 vs 9,50±4,83; p=0,0084 respectively). No differences in perioperative complications were observed.CONCLUSIONS: Results from this cohort study from a single center registry, shows that ERAS protocol is feasible also in T4 colorectal patients and enhance postoperative recovery in this group of patients.
In silico study and virtual Drug Screening of the FDA-approved approach with Molecular Docking.
Authors: Manavi Mohammad Amin 
Published: April 2021

Abstract
Aims: Coronavirus disease 2019 (COVID-19) has emerged in Wuhan, China, and because of fast transmission, it has led to its extensive prevalence in almost all countries, which has made it a global crisis. This study aims to recognize a possible small molecule as a main protease inhibitor versus the main protease protein of SARS-CoV-2 by the computational program.Methods: Virtual screening procedures like using molegro virtual docker, auto dock tools, and auto dock Vina, was done for more than 1600 FDA-approved medicines that download from the ZINC database, were employed to characterize new implied molecule inhibitors for the recently published crystal structure of the main protease protein of SARS-CoV-2. Result: The result indicates that Velpatasvir, angiotensin receptor blockers, cephalosporins, and also atorvastatin could fit adequately to the binding site of the main protease. Because of some other beneficial features, including anti-infectious, anti-inflammatory properties, and ADME profile, they might be a promising drug nominee for repurposing to the treatment of COVID-19.Discussion: Velpatasvir was selected by combining some virtual screening methods for furthers studies to find a suitable ligand for the treatment of COVID-19.
Pleomorphic Xanthoastrocytoma, Anaplastic Pleomorphic Xanthoastrocytoma, and Epithelioid Glioblastoma: Case Series with Clinical Characteristics, Molecular Features and Progression Relationship
Authors: Lin Zhiying , Yang Runwei , Zheng Haojie , Li Zhiyong , Yi Guozhong , Han Huixia , Wu Qianchao , Qi Songtao , Huang Guanglong 
Published: April 2021

Abstract
Background: Pleomorphic xanthoastrocytoma (PXA), anaplastic pleomorphic xanthoastrocytoma (A-PXA), and epithelioid glioblastoma (E-GBM) show overlapping features. However, little is known about their clinical characteristics, molecular features and relationship with progression. Methods: Fourteen patients diagnosed at Nanfang Hospital from 2016 to 2019 were enrolled, including eleven PXA patients, two A-PXA patients, and one E-GBM patient. All tumour tissue samples of the fourteen patients were examined by immunohistochemical staining (MGMT, VEGF, BRAF-V600E, etc.). The recurrent tumour tissue of the patient with E-GBM arising from A-PXA was screened to detect 11 glioma markers (MGMT, BRAF-V600E, etc.) and chromosome 1p/19q by next-generation sequencing (NGS).Results: The mean age of 13 patients with PXA or A-PXA was 25.4 years; twelve of these patients had tumours at supratentorial regions. VEGF positivity was detected in the tumour samples of 13 patients, MGMT positivity in 10 patients, and BRAF-V600E positivity in 7 patients. For the tumour sample of the E-GBM patient who survived for up to 10 years after the fourth resection, BRAF V600E was wild type in the sample obtained from the first surgery, while it was mutant in the second, third, and fourth surgeries. In contrast, the promoter status of MGMT in the four surgeries was unmethylated. The NGS results showed that the mutation frequencies of BRAF V600E in the second, third and fourth surgeries were 14.06%, 9.13% and 48.29%, respectively.Conclusions: Collectively, the results suggest that patients with A-PXA may relapse multiple times and eventually progress to E-GBM with the BRAF-V600E mutation.
Secondary metabolites in in vitro cultures of Siberian medicinal plants: Content, antioxidant properties, and antimicrobial characteristics
Authors: Milentyeva Irina , Le Violeta , Kozlova Oksana , Velichkovich Natalia , Fedorova Anastasiya , Loseva Anna , Yustratov Vladimir 
Published: April 2021

Introduction. Wild-crafting leads to the local extinction of many medicinal plants that are rich in phenolic substances. In vitro cultivation of cells and organs of higher plants can be the optimal solution to this problem. The research objective was to study the biosynthetic activity of in vitro extracts of wild Siberian plants.
Study objects and methods. The study featured callus, cell suspension, and hairy root extracts of such Siberian medicinal plants as Eleutherococcus senticosus, Codonopsis pilosula, Platanthera bifolia, and Saposhnikovia divaricata. They were obtained by in vitro cultivation using modified nutrient media of Murashige and Skoog and Gamborg. The content of secondary metabolites was studied using the methods of thin-layer and high-performance liquid chromatography. A set of in vitro experiments tested the antioxidant and antimicrobial activity of the extracts.
Results and discussion. All the samples demonstrated a high content of secondary metabolites of phenolic nature. Flavonoglycosides, apigenin, and rutin were found to be the predominant biologically active substances in the callus extracts. Flavonoglycosides dominated in the suspension extracts. The root extracts contained more caffeic acid, rutin, ecdysteroids, quercetin, apigenin, cardiofolin, and coleofolide than the callus and suspension cultures. The list of prevailing secondary metabolites in the root extracts included rutin, apigenin, coleofolide, and quercetin. All the extracts showed antimicrobial and antioxidant activity.
Conclusion. All the extracts demonstrated good antioxidant and antimicrobial properties. Therefore, they can be used for the production of pharmaceuticals and biologically active food supplements as they can be helpful against infectious diseases, as well as oncological, cardiovascular, and neurodegenerative diseases linked to oxidative stress.
Strong Antihemolytic and Antioxidant Properties of Aqueous Extract from Algerian Hammada elegans (Bge.) Botsch (Chenopodiaceae)
Authors: Asseli Brahim , Mahfoudi Reguia , Djeridane Amar , Yousfi Mohamed 
Published: April 2021

Background:
Research on medicinal plant antioxidants has emerged as a potential therapeutic
to prevent free radical generated damage in the human body. Hammada elegans Botsch
(popularly known as “Ajram”) is a xerophytic plant widely found in Laghouat region, but there are
only a few reports about the biological or chemical properties of these species. Hence, the aim of
this study is to investigate the antioxidant and the antihemolytic activities of hexanic, acetonic,
methanolic and aqueous extracts of aerial parts of Algerian Hammada elegans Botsch by employing
different in vitro assay systems.

Methods:
The total phenolic content, the flavonoid content and the condensed tannin amount were
analyzed using Folin-Ciocalteu, aluminum chloride and vanillin assays, respectively. The in vitro
antioxidant capacity of extracts was assessed by CUPRAC, iron chelating, ABTS•+ and antihemolytic
assays, and was expressed as EC50 values.

Results:
Among the analyzed extracts, the aqueous extract had the highest phenolic, flavonoid and
tannin contents. Also, this extract displayed the highest antioxidant capacities compared to the other
extracts and standards. Its EC50 value for ABTS radical-scavenging activity was 0.265 ± 0.003
mg/L. Moreover, this extract showed high iron (II) chelating ability (EC50 = 0.958 ± 0.001 mg/L),
and good antioxidant activity in the cupric ion reducing activity (CUPRAC) in a concentration dependent
manner (EC50 were 0.709 ± 0.002 mg/L). Additionally, this extract had the best antihemolytic
activity against AAPH-induced hemolysis (EC50=0.090 ± 0.004 mg/L).

Conclusion:
Our study revealed that the aqueous extract of Hammada elegans Botsch, is a potential
source of antioxidants which possess a high protective effect of membrane against free radical.
The Effectiveness of Care Bundles Including the Braden Scale for Preventing Hospital Acquired Pressure Ulcers in Older Adults Hospitalized in ICUs: A Systematic Review
Authors: Floyd Natalie A. , Dominguez-Cancino Karen A. , Butler Linda G. , Rivera-Lozada Oriana , Leyva-Moral Juan M. , Palmieri Patrick A. 
Published: April 2021

Background:Despite technological and scientific advances, Hospital Acquired Pressure Ulcers (HAPUs) remain a common, expensive, but preventable adverse event. The global prevalence ranges from 9% to 53% while three million people develop HAPUs in the United States and 60,000 people die from associated complications. HAPU prevalence is reported as high as 42% in ICUs (ICU) costing on average $48,000 to clinically manage.Objective:The purpose of this systematic review was to evaluate the effectiveness of multi-component interventions (care bundles), incorporating the Braden scale for assessment, in reducing the prevalence of HAPUs in older adults hospitalized in ICUs.Methods:This was a systematic review of the literature using the Cochrane method. A systematic search was performed in six databases (CINAHL, Cochrane Library, Google Scholar, JBI Evidence-Based Practice Database, PubMed, and ProQuest) from January 2012 until December 2018. Bias was assessed with the Critical Appraisal Skills Programme Checklist, and the quality of evidence was evaluated with the American Association of Critical-Care Nurses Levels of Evidence.Results:The search identified 453 studies for evaluation; 9 studies were reviewed. From the analysis, pressure ulcer prevention programs incorporated three strategies: 1) Evidence-based care bundles with risk assessments upon admission to the ICU; 2) Unit-based skincare expertise; and 3) Staff education with auditing feedback. Common clinical management processes included in the care bundles were frequent risk reassessments, daily skin inspections, moisture removal treatments, nutritional and hydration support, offloading pressure techniques, and protective surface protocols. The Braden scale was an effective risk assessment for the ICU. Through early risk identification and preventative strategies, HAPU programs resulted in prevalence reduction, less severe ulcers, and reduced care costs.Conclusion:Older adults hospitalized in the ICU are most vulnerable to developing HAPUs. Early and accurate identification of risk factors for pressure is essential for prevention. Care bundles with three to five evidence-based interventions, and risk assessment with the Braden scale, were effective in preventing HAPUs in older adults hospitalized in intensive care settings. Higher quality evidence is essential to better understanding the impact of HAPU prevention programs using care bundles with risk assessments on patient outcomes and financial results.
Privacy and Security
Authors:   CASIS Vancouver
Published: April 2021

On June 2nd, 2020, the Canadian Association for Security and Intelligence Studies (CASIS) Vancouver hosted its second digital roundtable event of the year titled, “Privacy and Security: Working Hand in Hand to Protect You Online.” This presentation featured Dr. Patrick Neal who has been involved in the public safety field since 1982. Dr. Neal’s presentation focused on the cohesiveness of privacy and security in the near future, privacy constructs, myths and harms of privacy, and privacy enhancing technologies. The subsequent roundtable discussion centered around Dr. Neal’s lecture in a question and answer period.
APA Citation
CASIS Vancouver. (2020). Privacy and security: working hand in hand to protect you online. The Journal of Intelligence, Conflict, and Warfare, 3(2), 61-65. https://journals.lib.sfu.ca/index.php/jicw/article/view/2407/1818.
Ex-Vivo Study, The Effect of Standardized Eurycoma longifolia Extract on The Enzyme Activity of Rosiglitazone N-Demethylase
Authors: Purwantiningsih Purwantiningsih , Hussin Abas Hj , Chan Kit Lam 
Published: April 2021

Eurycoma longifolia (E. longifolia) or also known as Earth Pasak in Indonesia, has been used widely, especially to increase stamina in men. The use of herbal medicines in the long run opens up the opportunities for the influence of herbal medicines on metabolic process of other substances. This study aimed to evaluate the effect of E. longifolia extract on rosiglitazone metabolism after oral administration for one and fourteen days, and its effect on rat body weight. The rats were divided into two groups, group for one day treatment (divided into 8 subgroups with n = 6: I (control), II to VIII (were given extract at doses of 1 to 1000 mg / kg BW) and 14 days (rats divided into 4 subgroups, n = 6 : I (control), II to IV (treated with extracts of doses 5, 25 and 50 mg / kg BW). At the end of the experiment, test animals were sacrificed and rosiglitazone N-demethylase activity in hepatocytes was determined by measuring the amount of formaldehid formed at 415 nm. The rosiglitazone N-demethylase activity in all groups was analyzed by analysis of variance (ANOVA) and Tukey Test (P <0.05). The percentage of the changing in the body weight in the 14 days treatment group was compared to the control group. The results showed there was a significant increased in the rosiglitazone N-demethylase activity after rats were treated with E. longifolia extract at doses of 5 to 1000 mg / kg BB, but was not significantly different at a dose of 1 mg / kg BW when compared with control group. For the 14 days treatment, there was no significant difference between the treatment group and the control group, both for the rosiglitazone N-demethylase enzyme activity or the changed of rat body weight.
Analisis Perencanaan Obat di RSUD Kelas C Kabupaten Banyuwangi
Authors: Musyarofah Ida Rosita , Satibi Satibi , Andayani Tri Murti 
Published: April 2021

Perencanaan merupakan tahap yang penting dalam pengadaan obat di instalasi farmasi rumah sakit. Tujuan penelitian adalah mengetahui efisiensi tahap perencanaan di Instalasi Farmasi RSUD Kelas C Kabupaten Banyuwangi. Rancangan penelitian termasuk penelitian deskriptif, pengumpulan data kuantitatif diambil secara retrospektif untuk menganalisis efisiensi pengelolaan obat tahap perencanaan tahun 2018 dengan mengambil data Rencana Kebutuhan Obat tahun 2018. Pengelolaan obat tahap perencanaan diukur efisiensi dengan menggunakan indikator standar pengelolaan obat tahap perencanaan. Hasil penelitian menunjukkan bahwa persentase kesesuaian dengan 10 penyakit terbesar 100%, persentase item dan jumlah obat yang diminta dengan yang diterima 100%, ketepatan perencanaan 70,43%±65,19%, kesesuaian item yang diminta dengan yang direncanakan 121,5 %, kesesuaian jumlah yang diminta dengan yang direncanakan 270 %±1027,29%. Kesimpulan dari penelitian ini bahwa di RSUD Kelas C Kabupaten Banyuwangi tahap perencanaan dikaitkan dengan indikator kesesuaian dengan 10 penyakit terbesar dan kesesuain penerimaan sudah efisien, dikaitkan dengan indikator ketepatan perencanaan dan kesesuaian item dan jumlah permintaan di RSUD Kelas C Kabupaten Banyuwangi belum efisien,
Pengaruh Penerapan Jaminan Kesehatan Nasional Terhadap Profil Obat Pasien Hipertensi di Puskesmas Kecamatan Pulogadung
Authors: Sukowati Yudha , Laksmitawati Dian Ratih , Anggraini Yusi , Restina Mita 
Published: April 2021

Jaminan Kesehatan Nasional (JKN) telah resmi dilaksanakan oleh Badan Penyelenggara Jaminan Sosial (BPJS) pada Bulan Januari 2014. Perubahan yang mendasar adalah masalah pembiayaan. Sebelum JKN menggunakan metode Free For Service (FFS), sesudah JKN menggunakan metode Indonesian Case Base Groups (INA-CBGs). Salah satu penyakit kronis yang membutuhkan pelayanan komprehensif dan terjadinya peningkatan jumlah pasien salah satunya adalah Hipertensi. Tujuan penelitian ini adalah untuk melihat pengaruh penerapan metode Indonesian Case Base Groups (INA-CBGs) pada program JKN terhadap profil pemenuhan obat pada pasien kronis hipertensi. Penelitian ini menggunakan desain longitudinal time series dengan alur penelitian data dilakukan secara retrospektif sebelum dan sesuah JKN dengan kriteria inklusi adalah pasien ASKES hipertensi yang merupakan pasien rutin dan melakukan rawat jalan di Puskesmas Kecamatan Pulogadung selama periode Januari 2013 – Desember 2015. Berdasarkan kriteria tersebut didapatkan sampel sebanyak 82 pasien. Data diambil berasal dari rekam medis, Laporan Permakaian dan Lembar Permintaan Obat (LPLPO), kartu stok, buku permintaan dan penerimaan obat, serta resep pasien hipertensi tahun 2013, 2014 dan 2015. Data penelitian ini dianalisis menggunakan uji asosiatif hubungan kausal (sebab akibat) untuk melihat seberapa besar pengaruh penerapan untuk metode Indonesian Case Base Groups (INA-CBGs) pada program JKN terhadap profil pemenuhan obat pada pasien kronis hipertensi dibandingkan dengan metode Free For Service (FFS). Hasil penelitian ini menunjukkan bahwa pada pasien hipertensi pada profil pengobatan menunjukkan tidak terdapat perbedaan sebelum dan sesudah JKN pada jumlah obat yang diterima oleh pasien, obat generik, kesesuaian dengan Daftar Obat Esensial Nasional (DOEN) dan Formularium Nasional (FORNAS).
Determinants of Compliance with Standard Practices of Pesticide Use Among Cocoa Farmers in Southwestern Nigeria
Authors: Agbongiarhuoy Anthony Eghe , Fawole Ogbaraeno Pippy 
Published: April 2021

Cocoa production in Nigeria is limited due to pests and diseases. In an attempt to control these, farmers apply pesticides which leave chemical residue in cocoa beans. There are established standard practices to address the abuse in use of pesticides. However, there is dearth of information on factors that predispose cocoa farmers to comply with approved standard practices. Therefore, determinants of compliance with standard practices of pesticide use by cocoa farmers in Southwestern Nigeria were investigated. A three-stage sampling procedure was used to select respondents. Two cocoa producing States (Oyo and Ondo) were purposively selected. Two Local Government Areas (LGAs) known for cocoa production were selected from each state. Systematic random sampling was used to select 10% of registered farmers to give 354 respondents. Interview schedule was used to collect data on respondents’ variables. Data were analysed using descriptive statistics and multiple regression at  0.05. Most farmers were male (70.3%) and had secondary education (31.9%). Respondents’ age and farmingexperience were 58.0 and 27.0 years, respectively. Farmers’ yield and annual income were 0.449 tonnes obtained from an average of 6.25 ha cocoa farm size andN1,331,519.60 equivalent to $3,698.67, respectively. Determinants of compliance with standard practices of pesticides use for both dosage and procedure were determined by age ( = -0.20), income ( = 0.15), exposure to information (= 0.36), constraints ( = -0.27) and accessibility to approved pesticides ( = -0.11). Exposure of farmers to information and realising more money motivates them to purchase approved pesticides that will aid compliance with standard practices. As age of farmer increases, the ability to comply will be limited. A farmer who is constraint with poor access to recommended pesticides will go for unapproved types which are against compliance. Concerted efforts should be put in place by relevant bodies to ensure sustainable income, information access for respondents in order to adhere to recommended protocols and enhanced cocoa yield.
Determinan Perilaku Lansia Dalam Pemanfaatan Posyandu Lansia Di Wilayah Kerja Puskesmas Payo Selincah Kota Jambi Tahun 2020
Authors: Muhammad Ifwazan Darusman Raden , Guspianto Guspianto , Reskiaddin La Ode 
Published: April 2021

Posyandu lansia merupakan sebuah program puskesmas yang ditujukan untuk memberikan pelayanan kesehatan bagi lansia dengan melibatkan peran serta masyarakat dan berbagai sektor. Laporan Dinas Kesehatan Kota Jambi tahun 2018 menunjukkan cakupan pelayanan kesehatan lansia di Puskesmas Payo Selincah Kota Jambi hanya sebesar 85,5% yaitu masih dibawah target SPM (100%). Data kehadiran lansia perbulan tahun 2019 di posyandu lansia Cempaka Harum dan Anggrek wilayah kerja Puskesmas Payo Selincah sangat rendah yaitu hanya 8 orang (2,1%) dan 7 orang (0,41%). Tujuan penelitian ini adalah untuk mengetahui determinan perilaku lansia dalam pemanfaatan posyandu lansia di wilayah kerja Puskesmas Payo Selincah Kota Jambi. Penelitian ini adalah penelitian kuantitatif dengan desain cross sectional, menggunakan teknik pengambilan sampel proportionate random sampling dengan jumlah sampel sebanyak 92 orang lansia. Penelitian dilakukan pada bulan juni hingga juli tahun 2020. Intrumen penelitian menggunakan kuesioner. Hasil penelitian diketahui 73,5% lansia tidak memanfaatkan posyandu. Hasil uji statistik chi-square diketahui p- value pengetahuan sebesar 0,408 (> 0,05), sikap sebesar 0,718 (> 0,05), jarak sebesar 0,000 (< 0,05), dukungan keluarga sebesar 1,000 (> 0,05) dan peran kader sebesar 0,000 (< 0,05). Terdapat hubungan yang signifikan antara faktor jarak dan peran kader dalam pemanfaatan posyandu lansia di wilayah kerja Puskesmas Payo Selincah Kota Jambi.
Kata Kunci : Lansia, Posyandu lansia, Jarak, Peran Kader