bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural course of untreated spinal cord cavernous malformations: a follow-up study within the initial 5 years after diagnosis
Authors: Santos Alejandro N. , Rauschenbach Laurèl , Darkwah Oppong Marvin , Gembruch Oliver , Saban Dino , Chen Bixia , Herten Annika , Schmidt Börge , Li Yan , Özkan Neriman , Jabbarli Ramazan , Wrede Karsten , Sure Ulrich , Dammann Philipp 
Published: December 2021

OBJECTIVE
Cavernous spinal cord malformations (SCMs) are believed to have a high rate of bleeding. The risk of intramedullary hemorrhage (IMH) or recurrent IMH and the neurological impact of bleeding events are important for clinical decision-making and could impact current treatment strategies.

METHODS
The authors screened their institutional database for patients with cavernous SCM treated between 2003 and 2020. Patients with complete MRI data sets and clinical baseline characteristics were included. Surgically treated patients were censored after cavernous SCM removal. Neurological functional status was obtained using the modified McCormick (MMcC) scale at diagnosis, first IMH, and second IMH. Kaplan-Meier and Cox regression analyses were performed to determine the cumulative 5-year risk for hemorrhage or rehemorrhage.

RESULTS
Seventy-one patients with cavernous SCM were analyzed. Cox regression analysis identified previous IMH (hazard ratio 7.86, 95% confidence interval 1.01–61.47, p = 0.049) as an independent predictor for rehemorrhage during the 5-year follow-up. The cumulative 5-year risk of bleeding or rebleeding was 41.3% for cavernous SCM. The MMcC score significantly deteriorated in 75% of patients after recurrent hemorrhage (p = 0.012).

CONCLUSIONS
During untreated 5-year follow-up, a considerably increased risk for hemorrhage or rehemorrhage was found in cavernous malformations of the spinal cord compared to cerebral cavernous malformations. Neurological function significantly deteriorates after the second bleeding. The probability of recurrent IMH increased significantly after initial presentation with hemorrhage.
Implications for Efficacy and Safety of Total Dose and Dose-Intensity of Neoadjuvant Gemcitabine-Cisplatin in Muscle-Invasive Bladder Cancer: Three-Week Versus Four-Week Regimen
Authors: Holmsten Karin , Omland Lise Høj , Als Anne Birgitte , Agerbæk Mads , Dohn Line Hammer , Lindberg Henriette , Jensen Niels Viggo , Carus Andreas , Moe Mette , Hosseini Abolfazl , Radkiewicz Cecilia , Pappot Helle , Ullén Anders 
Published: December 2021

BACKGROUND: Neoadjuvant cisplatin-based chemotherapy is standard care prior to radical cystectomy in patients with muscle-invasive bladder cancer (MIBC). OBJECTIVE: To assess efficacy and safety of two commonly used neoadjuvant schedules with different total doses and dose-intensities of gemcitabine and cisplatin (GC). METHODS: Data were collected retrospectively from all patients treated between 2010 and 2018 with neoadjuvant chemotherapy according to clinical routine at seven centres in Sweden and Denmark. Patients in Sweden received three cycles of a 4-week schedule (GC-4w: cisplatin 70 mg/m2 day 1, gemcitabine 1000 mg/m2 days 1, 8, 15, q 28 days) and in Denmark four cycles of a 3-week schedule (GC-3w: cisplatin 70 mg/m2 day 1, gemcitabine 1000 mg/m2 days 1, 8, q 21 days). Primary endpoint was pathological response at cystectomy (pT0N0 and < pT2N0). RESULTS: A total of 251 patients were treated with GC-4w and 455 with GC-3w. pT0N0 was significantly higher for patients treated with GC-3w compared to GC-4w, 46% versus 32% (adjusted odds ratio [aOR] 1.80; 95% confidence interval [CI] 1.16–2.80; P = 0.009); and for < pT2N0 60% versus 47% (aOR 1.08; 95% CI 0.70–1.66; P = 0.743). There were no significant differences between GC-4w and GC-3w regarding survival parameters. GC-3w patients discontinued treatment more frequently and showed a higher degree of neutropenia. CONCLUSIONS: A significantly higher complete response-rate was observed in the patient group treated with the more cisplatin-dose-intense 3-week schedule. The side-effect profile was in favor of the 4-week approach while relapse-free and overall survival were similar.
Amyloid Positive Hydrocephalus: A Hydrocephalic Variant of Alzheimer’s Disease?
Authors: Jang Hyemin , Park Yu-hyun , Choe Young Sim , Kang Sung Hoon , Kang Eun-Sook , Lee Seunghoon , Seo Sang Won , Kim Hee Jin , Na Duk L. 
Published: December 2021

Background: Alzheimer’s disease (AD) and normal pressure hydrocephalus (NPH) commonly coexist. Objective: We aimed to characterize an overlapping syndrome of AD and NPH that presents with gait disturbance, ventriculomegaly on magnetic resonance imaging, and significant amyloid deposition on positron emission tomography (PET). Methods: Of 114 patients who underwent cerebrospinal fluid (CSF) drainage for a possible diagnosis of NPH between 2015 and 2020 in Samsung Medical Center, we identified 24 patients (21.1%) with the NPH patients with amyloid deposition on PET, which we referred to as hydrocephalic AD in this study. We compared their clinical and imaging findings with those of 123 typical AD without hydrocephalic signs/symptoms. We also investigated the frequency and potential predictors of the tap test response in hydrocephalic AD. Results: Evans’ index was 0.36±0.03, and a disproportionately enlarged subarachnoid space was present in 54.2% of the hydrocephalic AD patients. The mean age (75.2±7.3 years) and the APOE4 frequency (68.2%) did not differ from those of AD controls. However, the hydrocephalic AD patients showed better memory and language performance, and a thinner cingulate cortex. About 42% of the hydrocephalic AD patients responded to the tap test, of whom seven underwent shunt surgery. Cognition did not improve, whereas gait improved after shunt surgery in all. Conclusion: Hydrocephalic AD has different neuropsychological and imaging characteristics from typical AD. Future studies are warranted to further investigate the effect of CSF removal on their clinical course and to elucidate the pathophysiological interaction between amyloid and NPH.
Associations Between Midlife Functional Limitations and Self-Reported Health and Cognitive Status: Results from the 1998–2016 Health and Retirement Study
Authors: Wu Benson , Toseef Mohammad Usama , Stickel Ariana M. , González Hector M. , Tarraf Wassim 
Published: December 2021

Background: Life-course approaches to identify and help improve modifiable risk factors, particularly in midlife, may mitigate cognitive aging. Objective: We examined how midlife self-rated physical functioning and health may predict cognitive health in older age. Methods: We used data from the Health and Retirement Study (1998–2016; unweighted- N = 4,685). We used survey multinomial logistic regression and latent growth curve models to examine how midlife (age 50–64 years) activities of daily living (ADL), physical function, and self-reported health affect cognitive trajectories and cognitive impairment not dementia (CIND) and dementia status 18 years later. Then, we tested for sex and racial/ethnic modifications. Results: After covariates-adjustment, worse instrumental ADL (IADL) functioning, mobility, and self-reported health were associated with both CIND and dementia. Hispanics were more likely to meet criteria for dementia than non-Hispanic Whites given increasing IADL impairment. Conclusion: Midlife health, activities limitations, and difficulties with mobility are predictive of dementia in later life. Hispanics may be more susceptible to dementia in the presence of midlife IADLs. Assessing midlife physical function and general health with brief questionnaires may be useful for predicting cognitive impairment and dementia in later life.
Prevalence, Incidence, and Progression of Cognitive Impairment, No Dementia Among Rural-Dwelling Chinese Older Adults
Authors: Ren Yifei , Dong Yi , Hou Tingting , Han Xiaolei , Liu Rui , Wang Yongxiang , Xu Shan , Wang Xiang , Monastero Roberto , Cong Lin , Du Yifeng , Qiu Chengxuan 
Published: December 2021

Background: Few studies have examined occurrence and progression of cognitive impairment, no dementia (CIND) in rural China. Objective: To determine the prevalence and incidence of CIND in rural-dwelling Chinese older adults, and to examine risk and protective factors associated with progression to CIND and dementia. Methods: This population-based study included 2,781 dementia-free participants (age≥65 years) who were examined at baseline (2014) and followed in 2018. Demographic, epidemiological, clinical, and neuropsychological data were collected following a structured questionnaire. We defined CIND according to subjective cognitive complaints and the age- and education-specific Mini-Mental State Examination (MMSE) score. Data were analyzed with the multinomial logistic regression models. Results: The overall prevalence of CIND was 10.54% and the incidence was 28.26 per 1,000 person-years. CIND at baseline was associated with the multi-adjusted odds ratio (OR) of 2.06 (95% confidence interval = 1.23–3.47) for incident dementia. Multinomial logistic regression analysis suggested that compared with no CIND, the multi-adjusted OR of incident CIND was 2.21 (1.51–3.23) for women and 0.62 (0.38–0.99) for high social support, whereas the multi-adjusted OR of incident dementia was 1.14 (1.09–1.18) for older age, 0.29 (0.16–0.53) for high education, and 2.91 (1.47–5.74) for having a stroke history. Conclusion: CIND affects over one-tenth of older adults living in rural communities of western Shandong province. People with CIND are twice as likely to progress to dementia as people without CIND. Female sex, low education, stroke history, and low social support are associated with an increased risk of progression from normal cognition to CIND or dementia.
KEMAMPUAN TIRAM (CRASSOSTREA SP) DALAM MENYERAP BAHAN ORGANIK TERSUSPENSI PADA AIR LIMBAH DOMESTIK (STUDI EKSPERIMEN)
Authors: Triana Relita , Rivai Abdur , Rostina Rostina 
Published: December 2021

Limbah adalah sesuatu yang tidak berguna, tidak memiliki nilai ekonomi dan akan dibuang, apabila masih dapat digunakan maka tidak disebut limbah. Masalah air limbah di Indonesia saat ini masih menjadi masalah yang serius. Tujuan penelitian ini adalah untuk uji coba kemampuan Tiram (Crassostrea sp) dalam menurunkan bahan organik tersuspensi pada air limbah domestik dengan metode penelitian eksperimen laboratorium, yaitu bentuk penelitian yang dilakukan dengan replikasi tiga kali dengan variasi jumlah Tiram (10 Tiram, 20 Tiram, 30 Tiram) dalam kurun waktu 24 jam dalam menyerap bahan organik tersuspensi (TSS) pada air limbah domestik. Hasil Penelitian diperoleh rata-rata persentasi penurunan bahan organik tersuspensi (TSS) pada air limbah domestik dengan jumlah 10 Tiram 66,67 %, 20 Tiram 72,5 %, 30 Tiram 85,84 % nilai ini tergolong sangat baik. Untuk hasil uji penelitian ini membuktikan bahwa penggunaan Tiram sebagai media penyerap mampu dan berfungsi dengan baik. Adapun pada penelitian ini yaitu media Tiram mampu menurunkan bahan organik tersuspensi (TSS) pada air limbah domestik dan memenuhi syarat baku mutu air limbah domestik. Di harapkan bagi masyarakat dapat menerapkan pengelolaan pada air limbah domestik dan bagi peneliti selanjutnya dapat menggunakan jenis Tiram yang lain dengan variasi ketebalan media yang akan digunakan. Kata Kunci : Air Limbah Domestik, TSS , Tiram (Crassostrea sp)
PEMETAAN KASUS DBD BERDASARKAN KONDISI LINGKUNGAN DI WILAYAH KERJA PUSKESMAS PRAMBON NGANJUK
Authors: Haidah Nur , Handini Riris 
Published: December 2021

Berdasarkan data dari Puskesmas Prambon (2017), Penderita DBD, DD dan DSS di wilayah kerja Puskesmas Prambon sebesar 20 orang, dengan ABJ sebesar 84,15%. Tujuan penelitian ini yaitu menggambarkan persebaran titik kasus DBD serta pemetaan lingkungan fisik, biologi dan sosial pada area radius 100 m dari titik kasus DBD di wilayah kerja Puskesmas Prambon Kabupaten Nganjuk.Penelitian ini berdasarkan sifatnya termasuk pada penelitian deskriptif sederhana. Pengumpulan data dilakukan dengan observasi rumah warga yang berada di radius 100 m dari titik kasus DBD. Populasi dalam penelitian ini sebanyak 238 rumah yang tersebar pada 11 titik kasus DBD di 7 desa di Wilayah Kerja Puskesmas Prambon Kab. Nganjuk. Data yang diperoleh selanjutnya dianalisis dalam bentuk peta dan diskriptif. Hasil penelitian menunjukkan pemetaan lingkungan fisik berdasarkan kasus DBD yang terdiri dari perilaku tidak menguras ditemukan pada 131 rumah (55,04%) sedangkan masyarakat yang tidak memiliki penutup kontainer yaitu 221 rumah (92,85%). Pemetaan lingkungan biologi berdasarkan kasus DBD yang terdiri dari rumah positif jentik ditemukan pada 68 rumah (28,57%) sedangkan ABJ 7 desa berada dibawah 95% yang berarti berada diluar standar. Pemetaan lingkungan sosial berdasarkan kasus DBD terdiri dari masyarakat yang belum mendapat penyuluhan ditemukan pada 23 rumah (9,66%) sedangkan masyarakat yang memiliki kebiasaan menggantung pakaian yaitu 191 rumah (80,25%). Disarankan perlu adanya pengoptimalan pelaksanaan program surveilans epidemiologi penyakit DBD dengan pendekatan lingkungan, melakukan pemetaan daerah endemik DBD dengan program SIG secara sederhana, meningkatan partisipasi kader desa dan masyarakat untuk menjaga lingkungan bersih dengan PSN dan kerja bakti.Kata kunci : DBD, Pemetaan, Kondisi Lingkungan.
KONDISI FAKTOR FISIK RUMAH DAN KEJADIAN ISPA DI DESA ALENANGKA KECAMATAN SINJAI SELATAN KABUPATEN SINJAI
Authors: Anantasia Fitrah , Mulyadi Mulyadi , Hidayat Hidayat 
Published: December 2021

Infeksi Saluran Pernapasan Akut (ISPA) merupakan salah satu masalah penyakit tertinggi yang ada di Kabupaten Sinjai. Tempat tinggal dengan ventilasi yang kurang memenuhi kriteria sehingga mengakibatkan pergantian oksigen kurang sempurna, lingkungan fisik rumah yang juga tidak memenuhi syarat, dan hampir setiap rumah masih menggunakan bahan bakar memasak dengan kayu bakar. Kondisi lingkungan yang seperti ini dikhawatirkan berpotensi akan kejadian ISPA dengan faktor-faktor yang ada.Penelitian ini ditujukan untuk mengetahui hubungan kondisi rumah dengan kejadian ISPA di Desa Alenangka Kecamatan Sinjai Selatan Kabupaten Sinjai. Jenis penelitian yang digunakan didalam penelitian ini yaitu obervasional analitik dan dianalisa secara cross sectional. Jumlah sampel sebanyak 44 rumah. Penelitian dilaksanakan selama satu bulan. Hasil analisis data dengan menggunakan uji korelasi pearson.Hasil penelitian menunjukkan data variabel ventilasi didapatkan nilai p = 0,219 (p > 0,05) berarti tidak ada hubungan dengan kejadian ISPA, variabel suhu dengan nilai p = 0,029 (p < 0,05) berarti ada hubungan dengan kejadian ISPA, variabel kelembaban dengan nilai p = 0,034 (p < 0,05) berarti ada hubungan dengan kejadian ISPA, dan variabel kepadatan hunian dngan nilai p = 0,123 (p > 0,05) berarti tidak ada hubungan dengan kejadian ISPA.Kata Kunci : Kejadian ISPA, Ventilasi, Suhu, Kelembaban, Kepadatan Hunian
EFEKTIVITAS LARUTAN DAN PARUTAN KUNYIT DALAM MENGAWETKAN IKAN BANDENG (CHANOS CHANOS)
Authors: Ayu Sri , Rappe Erlani 
Published: December 2021

ABSTRACT In the content contained in milkfish such as protein and fat is a suitable medium for the growth of spoilage bacteria or other microorganisms. One way to maintain its quality by providing preservatives to inhibit bacterial growth is to provide natural preservatives such as turmeric.The purpose of this study was to determine the effectiveness of turmeric as a preservative for milkfish (chanos chanos). This research is a quasi-experimental type of research, namely the treatment of the use of turmeric grater and solution as a preservative in milkfish (chanos chanos) to determine the physical durability of milkfish.The results of the physical condition examination were seen from the appearance of the eyes, surface mucus, meat, body texture in the preservation of milkfish using 65 grams of turmeric solution, showing contact time 1 hour, 8 hours, 16 hours, 21 hours organoleptic value did not exceed the minimum limit of 7, but contact time 22 hours shelf life has been damaged. The results of physical condition examination on milkfish preservation samples using 65 gr turmeric grated effectively preserved at the contact time of 23 hours while the contact time of 24 hours has been damaged. While the milkfish without treatment have suffered damage in the span of 8 hours.The conclusion obtained is that grated turmeric is better able to preserve milkfish in a long time compared to using turmeric solution. Suggestion We recommend using turmeric natural preservatives with grated turmeric to preserve milkfish because the durability of using turmeric grated is longer compared to the turmeric solution seen from physical conditions.
KONSEP KESERAGAMAN POLA SPASIAL LINGKUNGAN PERMUKIMAN BERBASIS SIG (SISTEM INFORMASI GEOGRAFIS) PADA KAWASAN MUARA SUNGAI TALLO KOTA MAKASSAR
Authors: Rohana Rohana , Paddiyatu Nurhikmah , Wahyuni Sri , Abdullah Gunawan 
Published: December 2021

Muara Sungai Tallo yang berada dibagian Utara Kota Makassar, yang terus tumbuh dan berkembang dari tahun ketahun. Saat ini dihuni oleh penduduk yang cukup padat dengan kondisi perumahan yang berhimpitan. Selain itu di daerah tersebut, terdapat perumahan yang dibangun di atas air yang telah melampaui sempadan sungai dengan kondisi sanitasi yang kurang sehat. Permukiman penduduk yang terus bertambah dengan memanfaatkan ruang sepanjang bantaran sungai. Hal ini menjadikan ruang-ruang dalam zona lindung berkurang sehingga perubahan ruang dapat berdampak pada ruang disekitarnya. Penelitian ini bertujuan untuk mengetahui bentuk pola spasial lingkungan kawasan permukiman pesisir Tallo yang berbasis SIG, dilihat dari perubahan ruang yang terjadi pada kawasan tersebut. Jenis penelitian ini adalah penelitian survey dengan menggunakan metode deskriptif kualitatif. Hasil dan Pembahasan Penelitian menunjukkan bahwa terdapat beberapa faktor yang terjadi pada Kawasan muara sungai tallo, khususnya yang terdapat di wilayah RW. 04 Kelurahan Tallo, diantaranya yaitu 1) Terjadinya perkembangan permukiman pada Kawasan pesisir yang semakin kumuh, 2) Degradasi fisik lingkungan, 3) Sarana dan prasarana mengalami penurunan kualitas terutama drainase dan sanitasi, 4) Pengelolaan sampah yang belum sesuai dengan anjuran pemerintah, 5) Belum tersedianya RTH yang sesuai dengan peruntukannya, 6) Perilaku masyarakat terhadap lingkungan, masih relatif rendah, 7) Tingkat kesejahteraan masyarakat, masih tergolong rendah. Oleh karena itu, untuk mengantisipasi perubahan ruang disekitar Kawasan pesisir, berbagai steakholder dan partisipasi masyarakat, sangat dibutuhkan kerjsamanya untuk bisa saling bahu-membahu dan bekerjasama untuk menjaga lingkungan dan memelihara sumberdaya yang ada dengan tidak mengotori dan tidak merusak berbagai sarana dan prasarana yang telah disediakan, baik dari pemerintah maupun dari pihak swasta. Selain itu, untuk menciptakan lingkungan hunian yang kondusif, dibutuhkan komunikasi yang efektif terhadap seluruh pihak serta dibutuhkan konsep manajemen pengelolaan Kawasan yang merupakan gagasan untuk memberikan pembelajaran dalam mengubah pemikiran, sikap dan perilaku masyarakat yang terorganisir dengan aturan-aturan atau kesepakatan yang dikelola secara bersama berdasarkan sistem manajemen. Kata kunci: Spasial, Permukiman, Lingkungan, Sungai Tallo
Musical activity in psycho-pedagogical perspective: analysis of works of the beginning of the XXI century
Authors: Braichenko Tetyana 
Published: December 2021

The purpose of the article is to reveal innovative views on the importance of musical activity in the symbiosis of psychological and pedagogical approaches. The methodology consists of the study and analysis of pedagogical, musicological, art history source base, analysis, systematization, and generalization of scientific and methodological sources. The scientific novelty of the work is to study the features of the study of musical activity from a psycho-pedagogical perspective, taking into account the changing socio-cultural environment of the early 21st century. Conclusions. Musical activity in scientific works of the 21st century is studied in the traditional psycho-pedagogical approach but taking into account innovative pedagogical concepts (K. Orff, Z. Kodai, J. Ducklcroze, S. Suzuki) and the introduction of an updated methodology. Among the relevant in the 21st-century methods of teaching music are as follows: alternation of different types of creativity, use of various creative methods, development of unity of motor and musical abilities, improvisation, active musical perception, the combination of collective and individual types of musical activity, participation in artistic and cultural events, communication with artists, the involvement of parents in education.
On the content of the "basic course of informatics" in the project "IT class in Moscow school"
Authors: Bosova L. L. , Pavlov D. I. , Tkach T. V. , Butarev K. V. 
Published: December 2021

The article discusses approaches to the organization of pre-professional training of students in 10–11th grades within the framework of the project "IT class in Moscow school", the task of which is to create a platform for training specialists in IT sphere. The basis for training students in informatics in the project "IT class in Moscow school" is the discipline "Basic informatics course", designed for two years of study, four hours a week. Thematic course planning is presented in the article. The content of the new textbook for the 11th grade is described in detail, including the following topics: "Graphics and multimedia", "Files and file system", "Modeling and game theory", "Databases", "Web programming", "Uneven coding, noiseproof codes", "Complexity of algorithms", "Algorithms", "Programming paradigms".
Penerapan metode ceramah online dalam pembelajaran di masa pandemi COVID-19
Authors: Usman Dia Hidayati , Mujahidin Endin , Fath Amir Faishol 
Published: December 2021

<p class="15bIsiAbstractBInggris"><em>This study aims to determine the extent to which the online lecture method due to the pandemic condition is effective in learning. The sample in this study was the Fath Sukawangi Islamic boarding school, Bogor, with a total of 70 respondents. The technique used in this research is descriptive quantitative through observation, interviews, direct field observations, and documentation. This study found two supporting factors, firstly, the availability of massive and easy-to-reach online facilities, both in the form of networks and the necessary tools such as computers and mobile phones. Second, the availability of information facilities on how to use and operate these facilities, either through the website or technical instructions distributed through many media, including Youtube. From the results of the study, it can be concluded that the lecture method in learning is still very strong in influence. This can be seen from the behavior of students who get better after participating in learning even though they are only listening to lectures online.</em></p><p class="15cKeywordsBInggris"> </p><p class="16aJudulAbstrak"><strong>Abstrak</strong></p><p class="16bIsiAbstrak">Penelitian ini bertujuan untuk mengetahui sejauh mana metode ceramah yang dilakukan secara <em>online</em> karena kondisi pandemik termasuk efektif dalam pembelajaran. Sebagai sampel pada penelitian ini adalah pesantren Fath Sukawangi Bogor, dengan total responden 70 orang. Teknik yang digunakan dalam penelitian ini adalah deskriptif kuantitatif melalui observasi, wawancara, peninjauan langsung ke lapangan dan dokumentasi. Penelitian ini menemukan dua faktor penunjang, pertama tersedianya fasilitas <em>online</em> secara masif dan mudah dijangkau, baik berupa jaringan maupun alat-alat yang dibutuhkan seperti komputer dan handphone. Kedua, tersedianya sarana informasi mengenai cara-cara menggunakan dan mengoperasikan fasilitas tersebut, baik melalui website atau petunjuk-petunjuk teknis yang disebarkan melalui banyak media di antaranya Youtube. Dari hasil penelitian dapat disimpulkan bahwa metode ceramah dalam pembelajaran masih sangat kuat pengaruhnya. Hal ini tampak dari perilaku peserta didik yang menjadi lebih baik setelah mengikuti pembelajaran sekalipun hanya menyimak ceramah melalui <em>online</em>.</p>