bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Prevalence and Clinical Correlates of Medical Disorders Comorbidities in Patients with Bipolar Disorder
Authors: Wang Zhonggang , Li Tao , Li Shuhua , Li Kunkun , Jiang Xianfei , Wei Chen , Yang Lei , Cao Haiyan , Li Shen , Li Jie 
Published: May 2021

Abstract
Objective: Medical disorders in patients with bipolar disorder (BD) have attracted more and more attention. So far, there is still a lack of studies on this issue utilizing large sample sizes in the Chinese sample. Therefore, we conducted this study to explore the clinical characteristics of BD patients comorbid medical disorders in a relatively large Chinese sample. Methods: This was a cross-sectional study including 1,393 BD patients (882 patients with medical disorders and 511 patients without medical disorders). Their demographic and clinical characteristics were obtained by the Hospital Information System and self-designed questionnaires. Results: The comorbidity rate of medical disorders in BD was 63.32%. The average number of medical disorders for a BD patient was 2.69. The top five comorbid medical disorders in BD patients were circulatory system diseases (19%), nervous system diseases (18%), endocrine and metabolic diseases (17%), digestive system diseases (16%), and respiratory system diseases (8%). BD patients with comorbid medical disorders had an older average age, lower education level, longer illness course, later onset age, lower ratio of psychotic features, more admission numbers, higher ratio of smoking and drinking alcohol, more number of manic episodes (All P < 0.05). Smoking, numbers of depressive episode, onset age, and illness course were independent risk factors of comorbidities in BD patients (All P < 0.05). Conclusions: Medical disorders in Chinese BD patients are highly prevalent. The smoking, number of depressive episodes, onset age, illness course, are correlated with BD patients comorbid medical disorders. Clinicians should pay attention to the medical disorders comorbidities in BD patients, and take effective measures to improve treatment outcome and reduce the suffering. The integrative approach should be the imperative in clinical practice.
Screen Time and Developmental Health: Results from an Early Childhood Study in Canada
Authors: Kerai Salima , Almas Alisa , Guhn Martin , Forer Barry , Oberle Eva 
Published: May 2021

Abstract
Background: Research has shown that longer hours of screen time are negatively associated with children's healthy development. Whereas most research has focused on school-age children, less is known about this association in early childhood. To fill this gap, our goal was to examine the association between screen time and developmental health in preschool-aged children.Methods: This study draws from a data linkage on children (N = 2983; Mean age = 5.2, SD = 0.3 years, 51% male) in British Columbia (BC), Canada, who entered Kindergarten in public elementary schools in 2019. Parent reports on children's screen time, health behaviors, demographics, and family income collected upon kindergarten entry (09/2019), were linked to teacher reports on children's developmental health, collected halfway through the school year (02/2020). Screen time was assessed with the Childhood Experiences Questionnaire. Developmental vulnerability versus developmental health in five domains (physical, social, emotional, language and cognition, and communication skills) was measured with the Early Development Instrument. Results: Logistic regression analyses using generalized estimating equation showed that children with more than one hour of daily screen time were more likely to be vulnerable in all five developmental health domains: physical health and wellbeing (odds ratio [OR] =1.41; 95% confidence interval [CI], 0.99 - 2.0; p=0.058), social competence (OR=1.60; 95% CI, 1.16 – 2.2; p=0.004), emotional maturity (OR=1.29; 95% CI, 0.96 - 1.73; p=0.097), language and cognitive development (OR=1.81; 95% CI, 1.19 - 2.74; p=0.006) and communication skills (OR=1.60; 95% CI, 1.1 – 2.34; p=0.015) compared to children reporting up to one hour of screen time/day. An interaction effect between income and screen time on developmental health outcomes was non-significant. Results were adjusted for child demographics, family income, and other health behaviors. Conclusion: Daily screen time that exceeds the recommended one-hour limit for young children, as suggested by the Canadian 24-hrs Movement Guidelines for Children and Youth [1, 2] is negatively associated with developmental health outcomes in early childhood. Screen-based activities should thus be limited for young children. Future research needs to examine the underlying mechanisms through which screen time is linked to developmental vulnerabilities.
Trends in Emotional Functioning and Psychosocial Wellbeing in Breast Cancer Survivors
Authors: Devarakonda Sri Kruthi , Timman Reinier , Bouvy Paul F. , Oemrawsingh Arvind , Apon Inge , Mureau Marc A.M. , Koppert Linetta B. , Kranenburg Leonieke W. 
Published: May 2021

Abstract
Purpose

A breast cancer diagnosis can threaten every aspect of a woman’s wellbeing, including her mental health. With the growing number of breast cancer survivors, longitudinal studies addressing mental health in this population are of increasing importance now more than ever. Therefore, the current study investigated trends in emotional functioning and psychosocial wellbeing of breast cancer survivors, and the demographic and treatment characteristics that may influence these trends.
Methods

Prospectively collected data of women treated for breast cancer at the Erasmus MC was analyzed in this study. Emotional functioning was measured using the EORTC-QLQ-C30, while psychosocial wellbeing was measured using the BREAST-Q. Type of surgery, age, family status and employment status of study participants were retrieved from patient files. Multilevel analysis was performed to identify trends in emotional functioning and psychosocial wellbeing and to determine the relationship between aforementioned characteristics and these trends.
Results

334 cancer survivors were analyzed. Psychosocial wellbeing declined, but emotional functioning showed a steady improvement over time. Type of surgery was associated with changes in emotional functioning and family status with changes in psychosocial wellbeing: women who underwent breast reconstruction showed a steeper increase in their emotional functioning and women with no partner or children showed a greater decline in psychosocial wellbeing between baseline and 12 months after surgery.
Conclusion

These findings can be utilized by healthcare teams to identify breast cancer patients at risk for emotional problems and to provide adequate psychological support to those women who need help dealing with their emotions and self-concept in order to optimize clinical treatment.
Computerized Clinical Decision Support Systems for Prescribing in Primary Care: Main Characteristics and Implementation Impact. Protocol of an Evidence and Gap Map.
Authors: Acosta-Garcia Hector , Ferrer-López Ingrid , Ruano-Ruiz Juan , Santos-Ramos Bernardo , Molina-López Teresa 
Published: May 2021

Abstract
Background
Computerized clinical decision support systems are used by clinicians at the point-of-care to improve quality of healthcare processes (prescribing error prevention, adherence to clinical guidelines...) and clinical outcomes (preventive, therapeutic, and diagnostics). Attempts to summarize results of computerized clinical decision support systems to support prescription in primary care have been challenging, and most systematic reviews and meta-analyses failed due to an extremely high degree of heterogeneity present among the included primary studies. The aim of our study will be to synthesize the evidence, considering all methodological factors that could explain these differences, and to build an evidence and gap map to identify important remaining research questions.
Methods
A literature search will be conducted from January 2010 onwards in Medline, Embase, The Cochrane Library and Web of Science databases. Two reviewers will independently screen all citations, full-text and abstract data. The study methodological quality and risk of bias will be appraised using appropriate tools if applicable. A flow diagram with the screened studies will be presented, and all included studies will be displayed using interactive evidence and gap maps. Results will be reported in accordance with recommendations from The Campbell Collaboration on the development of evidence and gap maps.
Discussion
Evidence behind computerized clinical decision support systems to support prescription use in primary care, has so far been difficult to be synthesized. Evidence and gap maps represent an innovative approach that has emerged and is increasingly being used to address a broader research question, where multiple types of intervention and outcomes reported may be evaluated. Broad inclusion criteria have been chosen with regards to study designs, in order to collect all available information. Regarding the limitations we will only include English and Spanish language studies from the last 10 years, we will not perform a grey literature search, and we will not carry out a meta-analysis due to the predictable heterogeneity of available studies.
Systematic Review registration:
This study is registered in Open Science Framework https://bit.ly/2RqKrWp
Gold Island-Enhanced Multiplex Quantum Dots Fluorescent System for Biomedical Analysis of Circulating Tumor Nucleic Acids
Authors: Lin Jingyan , Wu Yunxia , Yang Ronghua , Wang Jingru , Wu Wenjie , Chen Xiaodong , Chen Guoqiang , Liao Yuhui 
Published: May 2021

Abstract
Background: Circulating tumor nucleic acids (CTNAs) have been employed as the potential marker for tumor diagnosis and management, which are highly related to the tumorigenesis, progression and metastasis processes. Therefore, it is of significance to develop a highly-sensitive and reliable methods for detection of CTNAs, especially the multiplex point mutation detection of blood-derived CTNAs. Results: Herein, a gold island-enhanced multiplex quantum dots (QDs) fluorescent platform was constructed for highly-sensitive detection of CTNAs in serum. The gold island-enhanced multiplex fluorescent strategy was designed as the highly-efficient signal giving-out mode which could amplify the fluorescence of QDs, realized a homogeneous nano-platform for the enrichment, multiplex detection and point mutations monitoring of CTNAs with the principle of base-stacking. A high sensitivity of 10 amol and desirable specificity were achieved, and the performance index for analysis of clinical CTNAs samples indicated that the gold island-enhanced multiplex QDs fluorescent strategy could realize multiplex point mutations detection of CTNAs in complex blood samples. Conclusions: Hence, this platform achieved high detection rate in clinical samples that suitably met the clinical-requirements for multiplex detection and point mutations monitoring of CTNAs, and thus has the potential to serve as the tumor liquid biopsy strategy based on CTNAs.
Tuning The Primary Resonance of Vibrating Beam Micro-Gyroscopes Based On Piezoelectric Actuation and Multiple Nonlinearities
Authors: Li Wei , Chen Hong-Yan , Yang Hong 
Published: May 2021

Abstract
In this paper, the nonlinear dynamic characteristics of statically piezoelectric actuated vibrating beam micro-gyroscopes are studied. The comprehensive nonlinear model including curvature, inertia and electrostatic force nonlinearities is considered. In the research of electrostatic micro-gyroscopes, it’s a novel way to tune the primary resonance by piezoelectric actuation and multiple nonlinearities. The multiple scales method and numerical continuation technique are used to characterize the frequency-amplitude and force-amplitude responses of the micro-gyroscopes. The effect of varying the size-dependent, fringing field, statically piezoelectric voltage and nonlinear curvature and inertia on the dynamic response of the micro-gyroscope is investigated in detail. The frequency-response results show that small vibrations produce a symmetrical frequency response curve in sense direction while the system actually has a significant softening characteristic in drive direction. The nonlinear multi-value problem effectively reduces in sense direction under the size-dependent effect, which plays an important role in the design of detection instruments for micro-gyroscopes. Choosing a positive piezoelectric actuation voltage will obtain a higher sensitivity. Increasing the curvature nonlinearity and reducing the inertial nonlinearity of the gyroscopic system will help the micro-gyroscope obtain better sensitivity, and may eliminate multi-valued responses as much as possible.
Parenteral Succinate Reduces Levels of Reactive Oxygen Species, but It Does Not Reduce Caspase-3 Serum and Tissue Levels.
Authors: Chapela Sebastián Pablo , Muscogiuri Giovanna , Barrea Luigi , Frias-Toral Evelyn , Burgos Hilda , Ricart María Cecilia , Muryan Alexis , Schiel Amalia , Alonso Manuel , Stella Carlos Alberto 
Published: May 2021

Abstract
Purpose: In sepsis Reactive Oxygen Species (ROS) production and apoptosis are two physiopathological processes that are increased. Succinate is a Krebs cycle intermediate that is reduced in Complex II of the mitochondria. This work aims to determine if succinate administration to septic rats improves serum ROS levels and serum and tissue levels of apoptosis. Methods: Sepsis was induced with cecal ligation and puncture in 200gr Sprague Dawley rats. 4 groups were formed (control, succinate, sepsis, and sepsis + succinate). 5mml/kg of intraperitoneal succinate were administered to the succinate and sepsis + succinate groups 2 h before sepsis induction and 2 h before sample taking. ROS levels were measured with dichlorofluorescein-diacetate, and apoptosis was measured with a Caspase-3 ELISA kit. Results: There were significant differences in serum ROS levels between the control group and the sepsis group (P = 0.012), but there were no differences in serum Caspase-3 levels (P = 0.15). The succinate administration reduced serum ROS levels in the sepsis + succinate group compared with the sepsis group in a statistically significant way (P = 0.004), but it did not reduce serum Caspase-3 levels (P = 0.39). There were no differences between groups in kidney and liver Caspase-3 levels. There was no correlation between serum ROS levels and serum Caspase-3 levels. Conclusions: In this model, ROS levels were reduced with succinate infusion, but Caspase-3 levels were not. In addition, ROS levels and apoptosis levels are not correlated, which suggests that those processes occur at different times.
Post-azacitidine clone size predicts long-term clinical outcome of patients with myelodysplastic syndromes and related myeloid neoplasms
Authors: Ogawa Seishi , Tobiasson Magnus , Sato Shinya , Bernard Elsa , Ohtake Shigeki , Takeda June , Creignou Maria , Zhao Lanying , Kusakabe Manabu , Shibata Yuhei , Nakamura Nobuhiko , Watanabe Mizuki , Hiramoto Nobuhiro , Shiozawa Yusuke , Shiraishi Yuichi , Tanaka Hiroko , Yoshida Kenichi , Kakiuchi Nobuyuki , Makishima Hideki , Nakagawa Masahiro , Usuki Kensuke , Watanabe Mitsumasa , Imada Kazunori , Handa Hiroshi , Taguchi Masataka , Kiguchi Toru , Ohyashiki Kazuma , Ishikawa Takayuki , Takaori-Kondo Akifumi , Tsurumi Hisashi , Kasahara Senji , Chiba Shigeru , Naoe Tomoki , Miyano Satoru , Papaemmanuil Elli , Miyazaki Yasushi , Hellstrom-Lindberg Eva 
Published: May 2021

Abstract
Azacitidine is a mainstay of therapy for high-risk MDS and other myeloid neoplasms. A significant correlation between azacitidine response and clinical outcome suggests a potential role of mutational profiling based on next-generation sequencing (NGS) before and after therapy in evaluating response and predicting overall survival (OS), which however has not fully elucidated. Here through NGS-based mutational profiling of large cohorts (n=451) of azacitidine-treated patients with high-risk MDS and other myeloid neoplasms, we show significant roles of multi-hit TP53 and germline DDX41 mutations in pre-treatment samples and post-treatment clone size in the evaluation/prediction of azacitidine response and OS after azacitidine therapy, which outperformed the prediction based only on clinical response and IPSS-R score. Post-treatment clone size strongly correlated with clinical response with exception of large persistent mutations frequently affecting TET2 after achieving complete remission and those with DDX41 mutations, which poorly correlated with clinical response. Our results highlight the importance of evaluating mutations in both pre- and post-treatment samples in the assessment of response and the prediction of OS after azacitidine therapy.
Comparative Performance and Reliability Analysis of Doping and Junction Free Devices with High-κ/Vacuum Gate Dielectric
Authors: Kumar Rakesh , Panchore Meena , Bramhane Lokesh Kumar 
Published: May 2021

Abstract
A comparative evaluation of channel hot carrier (CHC) reliability and pursuance of dopingless FET (DL JLFET) and junctionless FET (JLFET) are studied for various dielectrics and compared with conventional dielectric (SiO2) JLFET. The use of dielectrics such as vacuum near the drain and the high-κ (HfO2) near the source in DL JLFET (VacuHDL JLFET) allows better pursuance and reliability against channel hot carrier (CHC) effects. A simulation study has shown that the pursuance of VacuHDL in terms of Ion/Ioff ratio is improved by 4.5, 19.38 and 39.58 times, respectively, in comparison with vacuum based DL, HJL and JL. Similarly, the intrinsic delay of VacuHDL is improved by 9.5%, 56.8 % and 58.7 %, respectively, in comparison with VacuDL, VacuHJL and VacuJL. Hence, VacuHDL is a potential candidate for digital circuit applications. Further, we have found that vacuum-based HDL and HJL are more immunes against CHC stress and shown that the drain current of vacuHDL and vacuHJL is reduced by 6.9 % and 17.5 %, respectively, in comparison with conventional dialectic (SiO2) based DL and JL which is 10.4 % and 20.5 %. Hence, the incorporation of vacuum dielectric towards drain terminal is helpful in reducing CHC induced effect in comparison with conventional dielectric.
Clinical and Histopathological Features of Early Gastric Cancer With Unclear Lateral Demarcation
Authors: Nagai Kengo , Hayashi Yoshito , Uema Ryotaro , Inoue Takanori , Kimura Keiichi , Sakatani Akihiko , Yoshii Shunsuke , Tsujii Yoshiki , Shinzaki Shinichiro , Iijima Hideki , Takehara Tetsuo 
Published: May 2021

Abstract
Background

Magnifying-endoscopy with narrow band imaging (M-NBI) is useful to determine lateral demarcation of early gastric cancers, but determining the lateral demarcation is sometimes difficult. Features related to the unclear lateral demarcation remain unknown. We evaluated the clinical and histopathological features of early gastric cancers with unclear lateral demarcation by M-NBI.
Methods

This single-center retrospective cohort study analyzed early gastric cancer treated by endoscopic submucosal dissection (ESD) from January 2013 to August 2015. We evaluated clinicopathological and immunohistochemical features using anti-p53, -Ki-67, -MUC5AC, -MUC6, -MUC2, and -CD10 antibody staining. We compared the lateral demarcation between the demarcation clear (DC) and demarcation unclear (DU) lesions by using M-NBI.
Results

A total of 224 differentiated adenocarcinomas (DU group: 18 lesions; DC group: 206 lesions) were analyzed. The history of successful Helicobacter pylori eradication was significantly more frequent in the DU group (p = 0.001). We examined tissues of 72 lesions immunohistochemically, including 18 lesions in the DU group and 54 randomly selected lesions in the DC group. Non-neoplastic superficial epithelium is more frequently observed in the DU group (p = 0.0058). Additionally, the DU group showed a significantly higher expression of gastric phenotype marker (p = 0.023), lower p53 score (p = 0.0002), and lower Ki-67 labeling index (p = 0.0293). The non-neoplastic superficial epithelium and low p53 score were significant independent variables associated with unclear lateral demarcation by M-NBI in the multivariate analysis.
Conclusions

Non-neoplastic superficial epithelium and low p53 score were associated with the difficultly in determining lateral demarcation in early gastric cancers by M-NBI.
The Perceptions and Experiences of Parents and Families of Preterm Infants Who Participate in Family Integrated Care Programs in Neonatal Intensive Care Units: A Qualitative Systematic Review Protocol
Authors: Carman Rebecca Anne , Adams Claire , Sharp Mary , McAullay Daniel , Marriott Rhonda , Jones Jocelyn , Strobel Natalie 
Published: May 2021

Abstract
BackgroundThe premature birth of an infant coupled with admission to a Neonatal Intensive Care Unit (NICU) can pose complex psychosocial challenges to parents and the family unit. Measures designed to counteract the effects of restricted visitation and prolonged separation from the infant within the NICU setting have led to the development of the Family Integrated Care model; emphasis in this program is placed on the active participation of the parent alongside the healthcare team in providing direct care to the preterm infant. The aim of this systematic review is to explore the perceptions and experiences of parents and families of preterm infants who have used a Family Integrated Care program during hospitalisation in a NICU. MethodsA systematic literature search will be performed on six electronic databases (Medline, CINAHL, Embase, PsycINFO, Web of Science, and Scopus) to identify relevant articles which meet the a priori inclusion criteria. A hand-search of the reference lists of all articles taken to full text review will supplement the search. The search will be limited to peer-reviewed, primary research articles written in English only; nil publication date restrictions will be applied. Two independent reviewers will screen all retrieved articles, perform the full-text review, critically appraise the included articles, and extract the data. Where consensus cannot be reached, a third reviewer will be consulted. To assess the quality of included studies and the risk of bias, the Critical Appraisal Skills Programme checklist will be used. Data will be extracted using a data extraction tool developed by the review team and piloted for use by two independent reviewers. A thematic analysis and narrative synthesis of the review findings will follow. DiscussionThis review will importantly describe the experiences of parents and families of preterm infants using a Family Integrated Care program delivered within a NICU; review findings will be used to inform the associated program protocols in a Perth (Western Australia) based NICU and be disseminated via a peer-reviewed publication. Systematic review registration: PROSPERO, Submission ID: 243818.