bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic Sleeve Gastrectomy with Omentopexy: Is It Really a Promising Method?—A Systematic Review with Meta-analysis
Authors: Zarzycki Piotr , Kulawik Jan , Małczak Piotr , Rubinkiewicz Mateusz , Wierdak Mateusz , Major Piotr 
Published: March 2021

Abstract
Purpose
Laparoscopic sleeve gastrectomy (LSG) is one of the most commonly performed bariatric procedure worldwide. Omentopexy during LSG is a novel variation of this well-established technique. There are no clear conclusions on indications for this procedure, safeness, and effects of such a method. We aimed to compare the outcomes of laparoscopic sleeve gastrectomy (LSG) with omentopexy (OP) and without omentopexy.

Materials and Methods
We searched the Medline, EMBASE, and Scopus databases up-to June 2020. Full-text articles and conference abstracts were included for further analysis. This review follows the PRISMA guidelines.

Results
Of initial 66 records, only 4 studies (N = 1396 patients) were included in the meta-analysis. Our findings showed that LSG with omentopexy had significantly lowered overall morbidity compared to LSG without omentopexy (RR = 0.38; 95% CI [0.15, 0.94]; p=0.04). Gastric leakage rate (RR = 0.17; 95% CI [0.04, 0.76]; p = 0.02) was also significantly lower in LSG with omentopexy. There were no significant differences between groups in length of hospital stay.

Conclusions
Our meta-analysis showed that LSG with omentopexy may be a feasible procedure for decreasing morbidity and gastric leak rate. However, despite promising results, the procedure needs to be researched more in randomized controlled studies to draw solid conclusions.
Fragments, Immersivity, and Reception: Punchdrunk on Aeschylus’ Kabeiroi
Authors: Cole Emma 
Published: March 2021

AbstractA preoccupation with fragmentation has defined many recent responses to antiquity. Within scholarship this focus takes the form of poststructuralist-informed readings, which highlight how any text can be perceived as fragmentary due to the epistemologies that we use to frame our readings. Within artistic practice there is a corresponding privileging of fragmentation through the dismembering of text. Yet one does not need to deconstruct a text, or to point to the gaps in meaning that persist in any textual encounter, to think through fragmentation.In this essay, I propose that utilising actual fragments within contemporary theatre is not simply an extension in scale of wider practice but represents a qualitatively different endeavour which holds unique benefits. I suggest that fragmentary texts represent fertile material for contemporary immersive performance, as the sense of lack contained within their form provides a productive impetus for an audience's creation of the unified imaginary world necessary for a ‘deep' form of immersion. Fragments and immersive theatre make for a unique partnership as the fragmentary source text holds synergy with the form of immersive performance, where a complete or ideal experience remains an ever-elusive ambition. I make my argument through an analysis of Punchdrunk's 2017 Kabeiroi, which turned the surviving fragments of Aeschylus' Kabeiroi into a four-to-six-hour immersive experience. I argue that a sense of yearning and incompletion is inevitable in the reception of ancient fragments, but that within immersive experiences this becomes a genuinely productive force. Punchdrunk's approach, I conclude, should be considered a useful method for other artists and represents a new possible direction for classical performance reception.
Computational aspects of infeasibility analysis in mixed integer programming
Authors: Witzig Jakob , Berthold Timo , Heinz Stefan 
Published: March 2021

AbstractThe analysis of infeasible subproblems plays an important role in solving mixed integer programs (MIPs) and is implemented in most major MIP solvers. There are two fundamentally different concepts to generate valid global constraints from infeasible subproblems: conflict graph analysis and dual proof analysis. While conflict graph analysis detects sets of contradicting variable bounds in an implication graph, dual proof analysis derives valid linear constraints from the proof of the dual LP’s unboundedness. The main contribution of this paper is twofold. Firstly, we present three enhancements of dual proof analysis: presolving via variable cancellation, strengthening by applying mixed integer rounding functions, and a filtering mechanism. Further, we provide a comprehensive computational study evaluating the impact of every presented component regarding dual proof analysis. Secondly, this paper presents the first combined approach that uses both conflict graph and dual proof analysis simultaneously within a single MIP solution process. All experiments are carried out on general MIP instances from the standard public test set Miplib 2017; the presented algorithms have been implemented within the non-commercial MIP solver and the commercial MIP solver .
Sr‐Enriched Glassy Picrites From the Karoo Large Igneous Province are Evolved, not Primitive Magmatic Rocks
Authors: Ashwal Lewis D. , Ziegler Alexander , Glynn Sarah , Truebody Tristan , Bolhar Robert 
Published: March 2021

AbstractMagmatic products of the Karoo Large Igneous Province can be divided into a volumetrically dominant, compositionally uniform low‐Ti tholeiitic suite, and a subordinate, geographically restricted, compositionally diverse, incompatible‐rich high‐Ti suite. High‐Ti picrites contain up to 2,400 ppm Sr, 1,900 ppm Ba, and 550 ppm Zr, which seems unusual for olivine‐enriched rocks. We studied six Karoo picrites to determine the phase(s) in which Sr resides. Samples consist of 10–30% olivine phenocrysts in a groundmass of brown glass, augite, feldspar, ilmenite, and apatite. Glass compositions vary, but are generally evolved, ranging from basaltic trachyandesite to dacite. X‐ray intensity maps demonstrate that most of the Sr resides in the glasses, and to a lesser extent, in feldspars, if present. Some samples contain two texturally and compositionally distinct glasses, best modeled in terms of magma hybridization: variably accumulated olivine phenocrysts surrounded by evolved Sr‐rich (to 9,470 ppm) Type 2 melts formed by extensive olivine fractionation were infiltrated by chemically distinct Type 1 melts. Upon eruption, Type 2 melt quenched to minor glass around olivine phenocrysts, and the dominant Type 1 glass acquired its evolved composition by quench crystallization of groundmass mineral phases. Both glasses are rich in H2O (up to 3.8 wt. %) but are nearly devoid of CO2. Calculated parental melts have much higher K2O and incompatible trace elements (e.g., Sr or Ba >1,200 ppm) relative to low‐Ti tholeiites. The unusual parental melt compositions imply derivation by small degrees of partial melting from SCLM mantle sources enriched in Sr and other incompatibles.
Crustal Structure of the UAE‐Oman Mountain Range and Arabian Rifted Passive Margin: New Constraints From Active and Passive Seismic Methods
Authors: Pilia S. , Ali M. Y. , Searle M. P. , Watts A. B. , Lü C. , Thompson D. A. 
Published: March 2021

AbstractThe Semail ophiolite, a thick thrust sheet of Late Cretaceous oceanic crust and upper mantle, was obducted onto the previously rifted Arabian continental margin in the Late Cretaceous, and now forms part of the United Arab Emirates (UAE)‐Oman mountain belt. A deep foreland basin along the west and SW margin of the mountains developed during the obduction process, as a result of flexure due to loading of the ophiolite and underlying thrust sheets. The nature of the crust beneath the deep sedimentary basins that flank the mountain belt, and the extent to which the Arabian continental crust has thickened due to the obduction process are outstanding questions. We use a combination of active‐ and passive‐source seismic data to constrain the stratigraphy, velocity structure and crustal thickness beneath the UAE‐Oman mountains and its bounding basins. Depth‐migrated multichannel seismic reflection profile data are integrated in the modeling of traveltimes from long offset reflections and refractions, which are used to resolve the crustal thickness and velocity structure along two E‐W onshore/offshore transects in the UAE. Additionally, we apply the virtual deep seismic sounding method to distant earthquake data recorded along the two transects to image crustal thickness variations. Active seismic methods define the Semail ophiolite as a high‐velocity body dipping to the east at 40°–45°. The new crustal thickness model presented in this work provides evidence that a crustal root is present beneath the Semail ophiolite, suggesting that folding and thrusting during the obduction process may have thickened the pre‐existing crust by 16 km.
Hemispheric and Seasonal Contrast in Cloud Thermodynamic Phase From A‐Train Spaceborne Instruments
Authors: Villanueva Diego , Senf Fabian , Tegen Ina 
Published: March 2021

AbstractAerosol‐cloud interactions are an important source of uncertainty in current climate models. To understand and quantify the influence of ice‐nucleating particles in cloud glaciation, it is crucial to have a reliable estimation of the hemispheric and seasonal contrast in cloud top phase, which is believed to result from the higher dust aerosol loading in boreal spring. For this reason, we locate and quantify these contrasts by combining three different A‐Train cloud‐phase products for the period 2007–2010. These products rely on a spaceborne lidar, a lidar‐radar synergy, and a radiometer‐polarimeter synergy. We show that the cloud‐phase from the product combination is more reliable and that the estimation of the hemispheric and seasonal contrast has a lower error compared to the individual products. To quantify the contrast in cloud‐phase, we use the hemispheric difference in ice cloud frequency normalized by the liquid cloud frequency in the southern hemisphere between −42 °C and 0 °C. In the midlatitudes, from −15 to −30 °C, the hemispheric contrasts increase with decreasing temperature. At −30 °C, the hemispheric contrast varies from 29% to 39% for the individual cloud‐phase products and from 52% to 73% for the product combination. Similarly, in the northern hemisphere, we assess the seasonal contrast between spring and fall normalized by the liquid cloud frequency during fall. At −30 °C, the seasonal contrast ranges from 21% to 39% for the individual cloud‐phase products and from 54% to 75% for the product combination.
Spring Temperature and Snow Cover Climatology Drive the Advanced Springtime Phenology (1991–2014) in the European Alps
Authors: Xie Jing , Hüsler Fabia , de Jong Rogier , Chimani Barbara , Asam Sarah , Sun Yeran , Schaepman Michael E. , Kneubühler Mathias 
Published: March 2021

AbstractShifts in phenology are important traces of climate change affecting mountainous ecosystems. We present an analysis of changes in spring phenology using a suite of Earth observation based parameters, that is, start of season (SOS), snow cover extent and meteorological variables from 1991 up to 2012/2014 for the European Alps. Our results show that SOS tends to occur earlier throughout the Alps during this period and spring temperatures have increased in the Eastern Alps. Spring temperatures presented a predominant influence on SOS for both, grasslands and forests across elevations between 500 and 2,200 m asl, while this effect is particularly pronounced in the northeastern Alps. Snow cover duration and snow cover melting days showed secondary impact on SOS. Our research provides a comprehensive observation of spatiotemporal changes in alpine spring vegetation phenology and its driving factors. They improve our understanding of the sensitivity of the European Alps ecosystems to a changing climate.
Dynamic blood single-cell immune responses in patients with COVID-19
Authors: Huang Lulin , Shi Yi , Gong Bo , Jiang Li , Zhang Zhixin , Liu Xiaoqi , Yang Jialiang , He Yongquan , Jiang Zhilin , Zhong Ling , Tang Juan , You Chunfang , Jiang Qi , Long Bo , Zeng Tao , Luo Mei , Zeng Fanwei , Zeng Fanxin , Wang Shuqiang , Yang Xingxiang , Yang Zhenglin 
Published: March 2021

AbstractThe 2019 coronavirus disease (COVID-19) outbreak caused by the SARS-CoV-2 virus is an ongoing global health emergency. However, the virus’ pathogenesis remains unclear, and there is no cure for the disease. We investigated the dynamic changes of blood immune response in patients with COVID-19 at different stages by using 5’ gene expression, T cell receptor (TCR), and B cell receptors (BCR) V(D)J transcriptome analysis at a single-cell resolution. We obtained single-cell mRNA sequencing (scRNA-seq) data of 341,420 peripheral blood mononuclear cells (PBMCs) and 185,430 clonotypic T cells and 28,802 clonotypic B cells from 25 samples of 16 patients with COVID-19 for dynamic studies. In addition, we used three control samples. We found expansion of dendritic cells (DCs), CD14+ monocytes, and megakaryocytes progenitor cells (MP)/platelets and a reduction of naïve CD4+ T lymphocytes in patients with COVID-19, along with a significant decrease of CD8+ T lymphocytes, and natural killer cells (NKs) in patients in critical condition. The type I interferon (IFN-I), mitogen-activated protein kinase (MAPK), and ferroptosis pathways were activated while the disease was active, and recovered gradually after patient conditions improved. Consistent with this finding, the mRNA level of IFN-I signal-induced gene IFI27 was significantly increased in patients with COVID-19 compared with that of the controls in a validation cohort that included 38 patients and 35 controls. The concentration of interferon-α (IFN-α) in the serum of patients with COVID-19 increased significantly compared with that of the controls in an additional cohort of 215 patients with COVID-19 and 106 controls, further suggesting the important role of the IFN-I pathway in the immune response of COVID-19. TCR and BCR sequences analyses indicated that patients with COVID-19 developed specific immune responses against SARS-CoV-2 antigens. Our study reveals a dynamic landscape of human blood immune responses to SARS-CoV-2 infection, providing clues for therapeutic potentials in treating COVID-19.
Millimetre wave channel modeling based on grey genetic optimization model
Authors: Geng Suiyan , Wen Yang , Zhao Xiongwen , Zhang Lei , Chen Suhong 
Published: March 2021

AbstractIn this paper, grey genetic optimization model (GGOM) is proposed for predicting insufficient channel parameters without increasing the amount of measurement data. Based on the millimetre wave 28 GHz indoor measurement data for both LOS and NLOS scenarios, the GGOM model is compared with traditional back propagation (BP) and grey model (GM) to analyse channel parameters like delay spread, excess delay and azimuth spread. Results show that the fitness of GGOM is better than the grey model in improving the stability of system. It works well with insufficient data (size less than 30) in most cases as it is set regardless of the specific scene and measurement data. This is verified by QuaDRiGa platform by generating uniformly distributed and interpolated data between the experimental measurement data. GGOM fits best with the measurement data compared with other prediction methods in channel characterization. Moreover, the mean absolute percentage error (MAPE) for GGOM is the least compared with GM and BP methods. The proposed GGOM model has good performance in modeling insufficient data of propagation channel, practically.
Shell nouns as register-specific discourse devices
Authors: Fang Alex Chengyu , Dong Min 
Published: March 2021

AbstractThis article provides a corpus-based investigation into shell nouns. Shell nouns perform a variety of referential functions and express speaker stance. The investigation was motivated by the fact that past research in this area has been primarily based on written texts. Very little is known about the use of shell nouns in speech. The study used the ICE-GB corpus of contemporary British English and investigated cataphoric shell nouns complemented by appositivethat-clauses across fine-grained spoken and written registers. It has revealed that the deployment of shell nouns is governed by the principle of register formality definable in terms of contextual configurations of the Field-Tenor-Mode complex rather than the mode of production. Additionally, the study has uncovered the frequent use of a small core set of shell nouns common across speech and writing. Hence it argues that shell nouns are part and parcel of spoken and written discourse and that they pertain more to grammar than to lexis.
“You turn your back and there’s somebody moving in”
Authors: Hopper Paul J. 
Published: March 2021

Abstract
Anacrustic Coordination (AC) is a type of biclausal conjunction such that an initial clause or phrase sets up a
state of affairs and is followed by and and a strongly focused second clause, for example three years
it’s been sitting here and I haven’t done it. AC figures in a number of kinds of interaction. One is the
topic/comment conditional, as in call it up and there’s something that actually says your number. It is a
possibility for enhancing certain illocutionary acts such as threats and warnings: I’m gonna take that and I’m gonna dig
it into you. It is a basis for syntactic mirativity, the coding of surprise and unexpectedness (DeLancey 1997): you turn your back and there’s somebody moving in. AC raises questions
about the nature of constructions and of Construction Grammar.
The grammar of proposals for joint activities
Authors: Thompson Sandra A. , Fox Barbara A. , Raymond Chase Wesley 
Published: March 2021

AbstractThe action of proposing has been studied from various perspectives in research on talk-in-interaction, both in mundane as well as in institutional talk. Aiming to exemplify Interactional Linguistics as a drawing together of insights from Linguistics and Conversation Analysis, we explore the grammar of proposals and the stances displayed by participants in making proposals in the context of joint activities, where a future or hypothetical activity is being put forth as something the speaker and recipient(s) might do together. Close examination of interactions among American English-speaking adults reveals four recurrent grammatical formats for issuing proposals:Let’s, Why don’t we, Modal Declaratives, and Modal Interrogatives. We argue that these four formats for doing proposing within a joint activity are used in socially distinct environments, contributing to a growing understanding of the fit between entrenched linguistic patterns and the social work they have evolved to do.
Formation and immunomodulatory function of meningeal B cell aggregates in progressive CNS autoimmunity
Authors: Mitsdoerffer Meike , Di Liberto Giovanni , Dötsch Sarah , Sie Christopher , Wagner Ingrid , Pfaller Monika , Kreutzfeldt Mario , Fräßle Simon , Aly Lilian , Knier Benjamin , Busch Dirk H , Merkler Doron , Korn Thomas 
Published: March 2021

Abstract
Meningeal B lymphocyte aggregates have been described in autopsy material of patients with chronic multiple sclerosis. The presence of meningeal B cell aggregates has been correlated with worse disease. However, the functional role of these meningeal B cell aggregates is not understood. Here, we use a mouse model of multiple sclerosis, the spontaneous opticospinal encephalomyelitis model, which is built on the double transgenic expression of myelin oligodendrocyte glycoprotein-specific T-cell and B-cell receptors, to show that the formation of meningeal B cell aggregates is dependent on the expression of α4 integrins by antigen-specific T cells. T cell-conditional genetic ablation of α4 integrins in opticospinal encephalomyelitis mice impaired the formation of meningeal B cell aggregates, and surprisingly, led to a higher disease incidence as compared to opticospinal encephalomyelitis mice with α4 integrin-sufficient T cells. B cell-conditional ablation of α4 integrins in opticospinal encephalomyelitis mice resulted in the entire abrogation of the formation of meningeal B cell aggregates, and opticospinal encephalomyelitis mice with α4 integrin-deficient B cells suffered from a higher disease burden than regular opticospinal encephalomyelitis mice. While anti-CD20 antibody-mediated systemic depletion of B cells in opticospinal encephalomyelitis mice after onset of disease failed to efficiently decrease meningeal B cell aggregates without significantly modulating disease progression, treatment with anti-CD19 chimeric antigen receptor-T cells eliminated meningeal B cell aggregates and exacerbated clinical disease in opticospinal encephalomyelitis mice. Since about 20% of B cells in organized meningeal B cell aggregates produced either IL-10 or IL-35, we propose that meningeal B cell aggregates might also have an immunoregulatory function as to the immunopathology in adjacent spinal cord white matter. The immunoregulatory function of meningeal B cell aggregates needs to be considered when designing highly efficient therapies directed against meningeal B cell aggregates for clinical application in multiple sclerosis.
Bioinformatics tools developed to support BioCompute Objects
Authors: Patel Janisha A , Dean Dennis A , King Charles Hadley , Xiao Nan , Koc Soner , Minina Ekaterina , Golikov Anton , Brooks Phillip , Kahsay Robel , Navelkar Rahi , Ray Manisha , Roberson Dave , Armstrong Chris , Mazumder Raja , Keeney Jonathon 
Published: March 2021

Abstract
Developments in high-throughput sequencing (HTS) result in an exponential increase in the amount of data generated by sequencing experiments, an increase in the complexity of bioinformatics analysis reporting and an increase in the types of data generated. These increases in volume, diversity and complexity of the data generated and their analysis expose the necessity of a structured and standardized reporting template. BioCompute Objects (BCOs) provide the requisite support for communication of HTS data analysis that includes support for workflow, as well as data, curation, accessibility and reproducibility of communication. BCOs standardize how researchers report provenance and the established verification and validation protocols used in workflows while also being robust enough to convey content integration or curation in knowledge bases. BCOs that encapsulate tools, platforms, datasets and workflows are FAIR (findable, accessible, interoperable and reusable) compliant. Providing operational workflow and data information facilitates interoperability between platforms and incorporation of future dataset within an HTS analysis for use within industrial, academic and regulatory settings. Cloud-based platforms, including High-performance Integrated Virtual Environment (HIVE), Cancer Genomics Cloud (CGC) and Galaxy, support BCO generation for users. Given the 100K+ userbase between these platforms, BioCompute can be leveraged for workflow documentation. In this paper, we report the availability of platform-dependent and platform-independent BCO tools: HIVE BCO App, CGC BCO App, Galaxy BCO API Extension and BCO Portal. Community engagement was utilized to evaluate tool efficacy. We demonstrate that these tools further advance BCO creation from text editing approaches used in earlier releases of the standard. Moreover, we demonstrate that integrating BCO generation within existing analysis platforms greatly streamlines BCO creation while capturing granular workflow details. We also demonstrate that the BCO tools described in the paper provide an approach to solve the long-standing challenge of standardizing workflow descriptions that are both human and machine readable while accommodating manual and automated curation with evidence tagging.
Database URL: https://www.biocomputeobject.org/resources