bluuebunny/crossref_metadata_2025_split huggingface dataset:
Matchings under distance constraints I.
Authors: Madarasi Péter 
Published: June 2021

AbstractThis paper introduces the d-distance matching problem, in which we are given a bipartite graph $$G=(S,T;E)$$

G
=
(
S
,
T
;
E
)

with $$S=\{s_1,\dots ,s_n\}$$

S
=
{

s
1

,
⋯
,

s
n

}

, a weight function on the edges and an integer $$d\in \mathbb Z_+$$

d
∈

Z
+

. The goal is to find a maximum-weight subset $$M\subseteq E$$

M
⊆
E

of the edges satisfying the following two conditions: (i) the degree of every node of S is at most one in M, (ii) if $$s_it,s_jt\in M$$

s
i

t
,

s
j

t
∈
M

, then $$|j-i|\ge d$$

|
j
-
i
|
≥
d

. This question arises naturally, for example, in various scheduling problems. We show that the problem is NP-complete in general and admits a simple 3-approximation. We give an FPT algorithm parameterized by d and also show that the case when the size of T is constant can be solved in polynomial time. From an approximability point of view, we show that the integrality gap of the natural integer programming model is at most $$2-\frac{1}{2d-1}$$

2
-

1

2
d
-
1

, and give an LP-based approximation algorithm for the weighted case with the same guarantee. A combinatorial $$(2-\frac{1}{d})$$

(
2
-

1
d

)

-approximation algorithm is also presented. Several greedy approaches are considered, and a local search algorithm is described that achieves an approximation ratio of $$3/2+\epsilon $$

3
/
2
+
ϵ

for any constant $$\epsilon >0$$

ϵ
>
0

in the unweighted case. The novel approaches used in the analysis of the integrality gap and the approximation ratio of locally optimal solutions might be of independent combinatorial interest.
Drivers of Philanthropic Foundations in Emerging Markets: Family, Values and Spirituality
Authors: Giacomin Valeria , Jones Geoffrey 
Published: June 2021

AbstractThis article discusses the ethics and drivers of philanthropic foundations in emerging markets. A foundation organizes assets to invest in philanthropic initiatives. Previous scholarship has largely focused on developed countries, especially the United States, and has questioned the ethics behind the activities of foundations, particularly for strategic motives that served wider corporate purposes. We argue that philanthropic foundations in emerging markets have distinctive characteristics that merit separate examination. We scrutinize the ethics behind the longitudinal activity of such foundations using 70 oral history interviews with business leaders in 18 countries in Africa, Asia, Latin America, and the Middle East. We find that 55 out of 70 foundations associated with these leaders have been used as vehicles for a specific type of philanthropic ethics defined as “spiritual philanthropy”. These foundations often embodied personal or family traditions, culture, and religious values, which emphasized charitable giving and social responsibility. As in the case of many of the industrial foundations in Europe, these foundations also carried founding family names and provided a structure to maintain family control and enhance corporate reputation. We argue that, as business leaders in emerging markets are more directly exposed to dire social, educational and health deprivation than their counterparts in developed countries, they are less inclined toward grandiose world-making, and their foundations are more focused on delivering immediate benefits to communities in their home countries, motivated by implicit or explicit spirituality.
Stability and Change of Psychopathology Symptoms Throughout Childhood and Adolescence
Authors: Blok Elisabet , de Mol C. Louk , van der Ende Jan , Hillegers Manon H. J. , Althoff Robert R. , Shaw Philip , White Tonya 
Published: June 2021

AbstractAssessing stability and change of children’s psychopathology symptoms can help elucidate whether specific behaviors are transient developmental variations or indicate persistent psychopathology. This study included 6930 children across early childhood (T1), late childhood (T2) and early adolescence (T3), from the general population. Latent profile analysis identified psychopathology subgroups and latent transition analysis quantified the probability that children remained within, or transitioned across psychopathology subgroups. We identified four psychopathology subgroups; no problems (T1: 85.9%, T2: 79.0%, T3: 78.0%), internalizing (T1: 5.1%, T2: 9.2%, T3: 9.0%), externalizing (T1: 7.3%, T2: 8.3%, T3: 10.2%) and the dysregulation profile (DP) (T1: 1.7%, T2: 3.5%, T3: 2.8%). From T1 to T2, 44.7% of the children remained in the DP. Between T2 and T3, 33.6% remained in the DP; however, 91.4% were classified in one of the psychopathology subgroups. Our findings suggest that for many children, internalizing or externalizing symptoms encompass a transient phase within development. Contrary, the DP resembles a severe at-risk state in which the predictive value for being in one of the psychopathology subgroups increases over time.
Combination therapy with pazopanib and tivantinib modulates VEGF and c-MET levels in refractory advanced solid tumors
Authors: Kummar Shivaani , Srivastava Apurva K. , Navas Tony , Cecchi Fabiola , Lee Young H. , Bottaro Donald P. , Park Sook Ryun , Do Khanh T. , Jeong Woondong , Johnson Barry C. , Voth Andrea R. , Rubinstein Larry , Wright John J. , Parchment Ralph E. , Doroshow James H. , Chen Alice P. 
Published: June 2021

SummaryThe vascular endothelial growth factor (VEGF)/VEGFR and hepatocyte growth factor (HGF)/c-MET signaling pathways act synergistically to promote angiogenesis. Studies indicate VEGF inhibition leads to increased levels of phosphorylated c-MET, bypassing VEGF-mediated angiogenesis and leading to chemoresistance. We conducted a phase 1 clinical trial with 32 patients with refractory solid tumors to evaluate the safety, pharmacokinetics, and pharmacodynamics of combinations of VEGF-targeting pazopanib and the putative c-MET inhibitor ARQ197 (tivantinib) at 5 dose levels (DLs). Patients either took pazopanib and tivantinib from treatment initiation (escalation phase) or pazopanib alone for 7 days, with paired tumor sampling, prior to starting combination treatment (expansion phase). Hypertension was the most common adverse event. No more than 1 dose limiting toxicity (DLT) occurred at any DL, so the maximum tolerated dose (MTD) was not determined; DL5 (800 mg pazopanib daily and 360 mg tivantinib BID) was used during the expansion phase. Twenty of 31 evaluable patients achieved stable disease lasting up to 22 cycles. Circulating VEGF, VEGFR2, HGF, and c-MET levels were assessed, and only VEGF levels increased. Tumor c-MET levels (total and phosphorylated) were determined in paired biopsies before and after 7 days of pazopanib treatment. Total intact c-MET decreased in 6 of 7 biopsy pairs, in contrast to previously reported c-MET elevation in response to VEGF inhibition. These results are discussed in the context of our previously reported analysis of epithelial-mesenchymal transition in these tumors.
Phase I study of daily and weekly regimens of the orally administered MDM2 antagonist idasanutlin in patients with advanced tumors
Authors: Italiano Antoine , Miller Wilson H. , Blay Jean-Yves , Gietema Jourik A. , Bang Yung-Jue , Mileshkin Linda R. , Hirte Hal W. , Higgins Brian , Blotner Steven , Nichols Gwen L. , Chen Lin Chi , Petry Claire , Yang Qi Joy , Schmitt Christophe , Jamois Candice , Siu Lillian L. 
Published: June 2021

Summary
Aim The oral MDM2 antagonist idasanutlin inhibits the p53-MDM2 interaction, enabling p53 activation, tumor growth inhibition, and increased survival in xenograft models. Methods We conducted a Phase I study of idasanutlin (microprecipitate bulk powder formulation) to determine the maximum tolerated dose (MTD), safety, pharmacokinetics, pharmacodynamics, food effect, and clinical activity in patients with advanced malignancies. Schedules investigated were once weekly for 3 weeks (QW × 3), once daily for 3 days (QD × 3), or QD × 5 every 28 days. We also analyzed p53 activation and the anti-proliferative effects of idasanutlin. Results The dose-escalation phase included 85 patients (QW × 3, n = 36; QD × 3, n = 15; QD × 5, n = 34). Daily MTD was 3200 mg (QW × 3), 1000 mg (QD × 3), and 500 mg (QD × 5). Most common adverse events were diarrhea, nausea/vomiting, decreased appetite, and thrombocytopenia. Dose-limiting toxicities were nausea/vomiting and myelosuppression; myelosuppression was more frequent with QD dosing and associated with pharmacokinetic exposure. Idasanutlin exposure was approximately dose proportional at low doses, but less than dose proportional at > 600 mg. Although inter-patient variability in exposure was high with all regimens, cumulative idasanutlin exposure over the whole 28-day cycle was greatest with a QD × 5 regimen. No major food effect on pharmacokinetic exposure occurred. MIC-1 levels were higher with QD dosing, increasing in an exposure-dependent manner. Best response was stable disease in 30.6% of patients, prolonged (> 600 days) in 2 patients with sarcoma. Conclusions Idasanutlin demonstrated dose- and schedule-dependent p53 activation with durable disease stabilization in some patients. Based on these findings, the QD × 5 schedule was selected for further development.

Trial registration
NCT01462175 (ClinicalTrials.gov), October 31, 2011.
The Impact of SRA-Programming on Computational Thinking in a Visual Oriented Programming Environment
Authors: Fanchamps Nardie L. J. A. , Slangen Lou , Specht Marcus , Hennissen Paul 
Published: June 2021

AbstractVisual programming environments are popular instruments in teaching Computational Thinking (CT) in schools today. Applying Sense-Reason-Act (SRA) programming can influence the development of computational thinking when forcing pupils to anticipate the unforeseen in their computer programs. SRA-programming originates from the programming of tangible robots, but can also be of equal value in visual programming with on-screen output. The underlying rationale is that programming in a visual programming environment using SRA leads to more understanding of the computational concepts addressed, resulting in a higher level of computational skill compared to visual programming without the application of SRA. Furthermore, it has been hypothesised that if pupils in a visual programming environment can anticipate unforeseen events and solve programming tasks by applying SRA, they will be better able to solve complex computational thinking tasks. To establish if characteristic differences in the development of computational thinking can be measured when SRA-programming is applied in a visual programming environment with an on-screen output, we assessed the applicability of SRA-programming with visual output as the main component of the execution of developed code. This research uses a pre-test post-test design that reveals significant differences in the development of computational thinking in two treatment conditions. To assess CT, the Computational Thinking Test (CTt) was used. Results show that when using SRA-programming in a visual programming environment it leads to an increased understanding of complex computational concepts, which results in a significant increase in the development of computational thinking.
How Are Curiosity and Interest Different? Naïve Bayes Classification of People’s Beliefs
Authors: Donnellan Ed , Aslan Sumeyye , Fastrich Greta M. , Murayama Kou 
Published: June 2021

AbstractResearchers studying curiosity and interest note a lack of consensus in whether and how these important motivations for learning are distinct. Empirical attempts to distinguish them are impeded by this lack of conceptual clarity. Following a recent proposal that curiosity and interest are folk concepts, we sought to determine a non-expert consensus view on their distinction using machine learning methods. In Study 1, we demonstrate that there is a consensus in how they are distinguished, by training a Naïve Bayes classification algorithm to distinguish between free-text definitions of curiosity and interest (n = 396 definitions) and using cross-validation to test the classifier on two sets of data (main n = 196; additional n = 218). In Study 2, we demonstrate that the non-expert consensus is shared by experts and can plausibly underscore future empirical work, as the classifier accurately distinguished definitions provided by experts who study curiosity and interest (n = 92). Our results suggest a shared consensus on the distinction between curiosity and interest, providing a basis for much-needed conceptual clarity facilitating future empirical work. This consensus distinguishes curiosity as more active information seeking directed towards specific and previously unknown information. In contrast, interest is more pleasurable, in-depth, less momentary information seeking towards information in domains where people already have knowledge. However, we note that there are similarities between the concepts, as they are both motivating, involve feelings of wanting, and relate to knowledge acquisition.
Understanding Cognitive Load in Digital and Online Learning: a New Perspective on Extraneous Cognitive Load
Authors: Skulmowski Alexander , Xu Kate Man 
Published: June 2021

AbstractCognitive load theory has been a major influence for the field of educational psychology. One of the main guidelines of the theory is that extraneous cognitive load should be reduced to leave sufficient cognitive resources for the actual learning to take place. In recent years, research regarding various design factors, in particular from the field of digital and online learning, have challenged this assumption. Interactive learning media, immersion, disfluency, realism, and redundant elements constitute five major challenges, since these design factors have been shown to induce task-irrelevant cognitive load, i.e., extraneous load, while still promoting motivation and learning. However, currently there is no unified approach to integrate such effects into cognitive load theory. By including aspects of constructive alignment, an approach aimed at fostering deep forms of learning in order to achieve specific learning outcomes, we devise a strategy to balance cognitive load in digital learning. Most importantly, we suggest considering both the positive and negative effects on cognitive load that certain design factors of digital learning can cause. In addition, a number of research results highlight that some types of positive effects of digital learning can only be detected using a suitable assessment method. This strategy of aligning cognitive load with desired learning outcomes will be useful for formulating theory-guided and empirically testable hypotheses, but can be particularly helpful for practitioners to embrace emerging technologies while minimizing potential extraneous drawbacks.
Unravelling climate change impacts from other anthropogenic influences in a subalpine lake: a multi-proxy sediment study from Oberer Soiernsee (Northern Alps, Germany)
Authors: Hofmann Andrea M. , Kuefner Wolfgang , Mayr Christoph , Dubois Nathalie , Geist Juergen , Raeder Uta 
Published: June 2021

AbstractMountain lakes are increasingly impacted by a series of both local and global disturbances. The present study reveals the eutrophication history of a remote subalpine lake (Oberer Soiernsee, Northern Alps, Germany), triggered by deforestation, alpine pasturing, hut construction, tourism and atmospheric deposition, and identifies the intertwined consequences of on-going global warming on the lake’s ecosystem. The primary objective was to disentangle the various direct and indirect impacts of these multiple stressors via down-core analyses. Our multi-proxy approach included subfossil diatom assemblages, carbon and nitrogen stable isotope ratios and subfossil pigments from dated sediments. Shifts within the diatom assemblages were related to variations in trophic state, lake transparency, water temperature and thermal stratification. The organic carbon isotope (δ13Corg) records, the diatom valve density and the pigment concentrations documented the development of primary production and composition. Total nitrogen isotope values (δ15N) are more likely to reflect the history of atmospheric nitrogen pollution than lake-internal processes, also mirrored by the decoupling of δ15N and δ13Corg trends. The composition of sedimentary pigments allowed a differentiation between planktonic and benthic primary production. Concordant trends of all indicators suggested that the lake ecosystem passed a climatic threshold promoted by local and long-distance atmospheric nutrient loadings.
Gaming Disorder in Adults with Autism Spectrum Disorder
Authors: Murray Alayna , Mannion Arlene , Chen June L. , Leader Geraldine 
Published: June 2021

AbstractGaming disorder (GD) is a clinical addiction to video or internet games. This study investigated whether GD symptoms are heightened in adults with autism spectrum disorder (ASD) in comparison to a control group, and explored predictors of GD in 230 adults with ASD and 272 controls. The relationship between GD and gelotophobia was examined. Measures included the Ten-Item Internet Gaming Disorder Test, GELOPH < 15 >, Autism Spectrum Quotient-10 items, Inventory of Parent and Peer attachment, Emotional Regulation Questionnaire, Social Functioning Questionnaire (SFQ) and the NEO-FFI-3. Individuals in the ASD group showed significantly higher symptoms of GD. Peer-attachment, emotional regulation and extraversion significantly predicted GD scores. Gelotophobia and GD were related to each other with a small effect size.
Alexithymic But Not Autistic Traits Impair Prosocial Behavior
Authors: Lischke Alexander , Freyberger Harald J. , Grabe Hans J. , Mau-Moeller Anett , Pahnke Rike 
Published: June 2021

AbstractSocial impairments are a core feature of autism-spectrum disorders. However, there is a considerable variability in these impairments. Most autistic individuals show large impairments in social functioning but some autistic individuals show small impairments in social functioning. The variability of these impairments has been attributed to the presence or absence of alexithymia. To address this issue, we capitalized on the fact that alexithymic and autistic traits are broadly distributed in the population. This allowed us to investigate how alexithymic and autistic traits affect social functioning in healthy individuals. Healthy individuals showed impairments on a resource-allocation task that were due to alexithymic but not autistic traits. These findings suggest that alexithymic rather than autistic traits impair prosocial behavior across the autism-spectrum.
A Quick Measure of Theory of Mind in Autistic Adults: Decision Accuracy, Latency and Self-Awareness
Authors: Brewer Neil , Young Robyn L. , Norris Jade Eloise , Maras Katie , Michael Zoe , Barnett Emily 
Published: June 2021

AbstractAutistic adults often experience difficulties in taking the perspective of others, potentially undermining their social interactions. We evaluated a quick, forced-choice version of the Adult Theory of Mind (A-ToM) test, which was designed to assess such difficulties and comprehensively evaluated by Brewer et al. (2017). The forced-choice version (the A-ToM-Q) demonstrated discriminant, concurrent, convergent and divergent validity using samples of autistic (N = 96) and non-autistic adults (N = 75). It can be administered in a few minutes and machine-scored, involves minimal training and facilitates large-scale, live, or web-based testing. It permits measurement of response latency and self-awareness, with response characteristics on both measures enhancing understanding of the nature and extent of perspective taking difficulties in autistic individuals.
Feedback Relevance Spaces: Interactional Constraints on Processing Contexts in Dynamic Syntax
Authors: Howes Christine , Eshghi Arash 
Published: June 2021

AbstractFeedback such as backchannels and clarification requests often occurs subsententially, demonstrating the incremental nature of grounding in dialogue. However, although such feedback can occur at any point within an utterance, it typically does not do so, tending to occur at Feedback Relevance Spaces (FRSs). We present a corpus study of acknowledgements and clarification requests in British English, and describe how our low-level, semantic processing model in Dynamic Syntax accounts for this feedback. The model trivially accounts for the 85% of cases where feedback occurs at FRSs, but we also describe how it can be integrated or interpreted at non-FRSs using the predictive, incremental and interactive nature of the formalism. This model shows how feedback serves to continually realign processing contexts and thus manage the characteristic divergence and convergence that is key to moving dialogue forward.
‘I Think it Just Made Everything Very Much More Intense’: A Qualitative Secondary Analysis Exploring The Role Of Friends and Family Providing Support to Survivors of Domestic Abuse During The COVID-19 Pandemic
Authors: Gregory Alison , Williamson Emma 
Published: June 2021

AbstractThe COVID-19 pandemic, and associated social restrictions, have amplified women’s experiences of domestic abuse (DA). In usual times, female DA survivors reach out to those around them (friends, family members, neighbors, and colleagues) for support. Accessing of both professional and informal support by survivors has increased during the pandemic. Informal supporters are often deeply invested and immersed in situations of DA because of the closeness of relationships. The accounts of informal supporters are rarely sought, yet these are people who may have a considerable awareness of what is happening. The aim of this study was to explore how the pandemic had impacted people’s assessment of abusive situations and their ability to provide informal support. This paper reports a secondary analysis of qualitative data collected in 2020 in England. The data were gathered in 18 in-depth interviews with people who knew a female friend, relative, neighbor, or colleague who had experienced DA. The age range of participants was 25–69 years, three were men and fifteen were women. A reflexive thematic analysis was carried out. Findings indicated: (i) the pandemic had changed people’s ability to read situations and assess risk (ii) perpetrators were exploiting the pandemic to further abuse (iii) within the context of the pandemic there was additional challenge to offering support (iv) informal supporters found creative ways to remain in-touch and to continue offering support. Further research with informal supporters is needed to ascertain how best to support and equip people, without imposing an impossible burden.
Optimal exercise of American put options near maturity: A new economic perspective
Authors: Battauz Anna , De Donno Marzia , Gajda Janusz , Sbuelz Alessandro 
Published: June 2021

AbstractThe critical price $$S^{*}\left( t\right) $$

S

∗

t

of an American put option is the underlying stock price level that triggers its immediate optimal exercise. We provide a new perspective on the determination of the critical price near the option maturity T when the jump-adjusted dividend yield of the underlying stock is either greater than or weakly smaller than the riskfree rate. Firstly, we prove that $$S^{*}\left( t\right) $$

S

∗

t

coincides with the critical price of the covered American put (a portfolio that is long in the put as well as in the stock). Secondly, we show that the stock price that represents the indifference point between exercising the covered put and waiting until T is the European-put critical price, at which the European put is worth its intrinsic value. Finally, we prove that the indifference point’s behavior at T equals $$S^{*}\left( t\right) $$

S

∗

t

’s behavior at T when the stock price is either a geometric Brownian motion or a jump-diffusion. Our results provide a thorough economic analysis of $$S^{*}\left( t\right) $$

S

∗

t

and rigorously show the correspondence of an American option problem to an easier European option problem at maturity .