bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prenatal and Infancy Home Visiting in Germany: 7-Year Outcomes of a Randomized Trial
Authors: Kliem Sören , Sandner Malte 
Published: July 2021

OBJECTIVESGiven the lasting positive effects of prenatal and infancy home visiting in the United States on disadvantaged mothers and children at school age, we analyzed the follow-up effects of a German home visiting program (ProKind). We hypothesized improvements in 3 domains at child age 7 years: (1) child development and life satisfaction, (2) maternal mental health and life satisfaction, and (3) adverse parenting, abusive parenting, and neglectful parenting.METHODSWe conducted a randomized controlled trial of home visiting, enrolling 755 pregnant, low-income women with no previous live births. The intervention comprised 32.7 home visits by family midwives and/or social pedagogues until child age 2 years. Assessments were completed on 533 7-year-old firstborn offspring to evaluate 8 primary hypotheses.RESULTSWe found significant positive effects for 4 of the 8 primary hypotheses. Mothers in the intervention group reported fewer behavioral problems among their children in the Child Behavior Checklist (effect size [ES] = 0.21; 95% confidence interval [CI]: 0.03 to 0.38), less child abusive parenting (ES = 0.19; 95% CI: 0.00 to 0.37), fewer maternal mental health problems (ES = 0.25; 95% CI: 0.07 to 0.43), and higher maternal life satisfaction (ES = 0.25; 95% CI: 0.07 to 0.43). Additional preregistered subgroup analyses regarding child sex revealed larger effects for boys and mothers of boys.CONCLUSIONSThe results suggest that in a western European welfare state, home visiting targeting disadvantaged mothers has lasting effects in important outcome domains. Therefore, home visits also appear to be an effective and efficient public health intervention in European settings.
Six Month Follow-up of Patients With Multi-System Inflammatory Syndrome in Children
Authors: Capone Christine A. , Misra Nilanjana , Ganigara Madhusudan , Epstein Shilpi , Rajan Sujatha , Acharya Suchitra S. , Hayes Denise A. , Kearney Mary Beth , Romano Angela , Friedman Richard A. , Blaufox Andrew D. , Cooper Rubin , Schleien Charles , Mitchell Elizabeth 
Published: July 2021

BACKGROUND AND OBJECTIVES
Myocardial dysfunction and coronary abnormalities are prominent features of multisystem inflammatory syndrome in children (MIS-C). In this study we aim to evaluate the early and midterm outcomes of MIS-C.

METHODS
This is a longitudinal 6-month cohort study of all children admitted and treated for MIS-C from April 17 to June 20, 2020. Patients were followed ∼2 weeks, 8 weeks, and 6 months postadmission, with those with coronary aneurysms evaluated more frequently.

RESULTS
Acutely, 31 (62%) patients required intensive care with vasoactive support, 26 (52%) had left ventricular (LV) systolic dysfunction, 16 (32%) had LV diastolic dysfunction, 8 (16%) had coronary aneurysms (z score ≥2.5), and 4 (8%) had coronary dilation (z score &lt;2.5). A total of 48 patients (96%) received immunomodulatory treatment. At 2 weeks, there was persistent mild LV systolic dysfunction in 1 patient, coronary aneurysms in 2, and dilated coronary artery in 1. By 8 weeks through 6 months, all patients returned to functional baseline with normal LV systolic function and resolution of coronary abnormalities. Cardiac MRI performed during recovery in select patients revealed no myocardial edema or fibrosis. Some patients demonstrated persistent diastolic dysfunction at 2 weeks (5, 11%), 8 weeks (4, 9%), and 6 months (1, 4%).

CONCLUSIONS
Children with MIS-C treated with immunomodulators have favorable early outcomes with no mortality, normalization of LV systolic function, recovery of coronary abnormalities, and no inflammation or scarring on cardiac MRI. Persistence of diastolic dysfunction is of uncertain significance and indicates need for larger studies to improve understanding of MIS-C. These findings may help guide clinical management, outpatient monitoring, and considerations for sports clearance.
Reviewing Christopher Witmore’s Old Lands: A Chorography of the Eastern Peloponnese (London: Routledge, 2020)
Authors: Witmore Christopher , Caraher William , González-Ruibal Alfredo , Hanink Johanna 
Published: July 2021

a) A Journey to A Chorography: Christopher Witmore
b) Old Ways in Old Lands: William Caraher
c) Manifesting the Infraordinary: Alfredo González-Ruibal
d) This Old Land: Johanna Hanink
e) Re-Grounding Chorographically: Christopher Witmore
Bathing epilepsy: a video case report
Authors: Cappellari Alberto M. , Bulgaro Chiara , Bruschi Gaia , Papa Marco 
Published: July 2021

AbstractBathing epilepsy is a rare form of reflex epilepsy triggered by bathing in room temperature water. It predominates in boys with a mean age of 15 months and its evolution is benign. Diagnosis of bathing epilepsy requires the exclusion of other paroxysmal disorders triggered by water contact. Video‐EEG confirmation of the seizures is necessary to reach a diagnosis of certainty and to allow adequate management. We present the case of a one‐year‐old boy who experienced recurrent episodes of unresponsiveness and cyanosis while bathing in lukewarm water. The diagnosis of bathing epilepsy was confirmed by the video‐EEG recording of a seizure, showing left‐sided frontotemporal delta activity with rapid contralateral spread. Therapy with levetiracetam was effective, subsequently allowing bathing without further seizures.
Current medico‐psycho‐social conditions of patients with West syndrome in Japan
Authors: Yoshitomi Shinsaku , Hamano Shin‐ichiro , Hayashi Masaharu , Sakuma Hiroshi , Hirose Shinichi , Ishii Atsushi , Honda Ryoko , Ikeda Akio , Imai Katsumi , Jin Kazutaka , Kada Akiko , Kakita Akiyoshi , Kato Mitsuhiro , Kawai Kensuke , Kawakami Tamihiro , Kobayashi Katsuhiro , Matsuishi Toyojiro , Matsuo Takeshi , Nabatame Shin , Okamoto Nobuhiko , Ito Susumu , Okumura Akihisa , Saito Akiko , Shiraishi Hideaki , Shirozu Hiroshi , Saito Takashi , Sugano Hidenori , Takahashi Yukitoshi , Yamamoto Hitoshi , Fukuyama Tetsuhiro , Kuki Ichiro , Inoue Yushi ,   Japan Rare Epilepsy Syndrome Registry Group: JRESG
Published: July 2021

AbstractObjective. To unveil current medical and psychosocial conditions of patients with West syndrome in Japan.Methods. A cross‐sectional analysis was performed in patients with West syndrome registered in the Rare Epilepsy Syndrome Registry (RES‐R) of Japan. Furthermore, new‐onset patients registered in the RES‐R were observed prospectively and their outcomes after one and two years of follow‐up were compared with data at onset.Results. For the cross‐sectional study, 303 patients with West syndrome were included. Seizures (such as spasms, tonic seizures and focal seizures) occurred daily in 69.3% of the patients at registration. Seizure frequency of less than one per year was observed in cases of unknown etiology (22.6%), genetic etiology (23.8%) and malformation of cortical development (MCD; 19.1%). Neurological findings were absent in 37.0%, but a high rate of abnormality was seen in patients with Aicardi syndrome, hypoxic‐ischemic encephalopathy (HIE), genetic etiology and MCD other than focal cortical dysplasia, accompanied by a >50% rate of bedridden patients. Abnormal EEG was found in 96.7%, and CT/MRI was abnormal in 62.7%. Treatments included antiepileptic drug therapy (94.3%), hormonal therapy (72.6%), diet therapy (8.3%) and surgery (15.8%). Intellectual/developmental delay was present in 88.4%, and was more severe in patients with Aicardi syndrome, genetic etiology and HIE. Autism spectrum disorder was found in 13.5%. For the longitudinal study, 27 new‐onset West syndrome patients were included. The follow‐up study revealed improved seizure status after two years in 66.7%, but worsened developmental status in 55.6%, with overall improvement in 51.9%.Significance. The study reveals the challenging neurological, physical and developmental aspects, as well as intractable seizures, in patients with West syndrome. More than a half of the children showed developmental delay after onset, even though seizures were reduced during the course of the disease.
Paroxysmal tonic upgaze in a child with SCN8A‐related encephalopathy∗
Authors: Solazzi Roberta , Castellotti Barbara , Canafoglia Laura , Messina Giuliana , Magri Stefania , Freri Elena , Ragona Francesca , Franceschetti Silvana , Di Francesco Jacopo C. , Gellera Cinzia , Granata Tiziana 
Published: July 2021

AbstractPathogenic variants in the SCN8A gene have been associated with a broad phenotypic spectrum, ranging from benign familial infantile seizures to severe, early‐onset developmental and epileptic encephalopathy. This spectrum also includes an “intermediate phenotype” characterized by different degrees of cognitive disability, mild neurological impairment, and therapeutically manageable epilepsy. We report on a child harbouring a de novo, novel SCN8A deletion, whose clinical picture is consistent with an SCN8A‐related “intermediate phenotype”. This patient's peculiar feature is the occurrence of paroxysmal tonic upgaze (PTU), a non‐epileptic disorder consisting of sustained conjugate upward deviation of the eyes, with neck flexion, and downbeat saccades. PTU has been described in otherwise healthy children, as well as in a few genetic syndromes, but has never been observed in SCN8A‐related phenotypes. This report, therefore, adds a new symptom to the spectrum of movement disorders associated with SCN8A‐related developmental and epileptic encephalopathy. In this short communication, we provide video‐EEG documentation of PTU and seizures, and discuss the challenging differential diagnosis between the two symptoms.
Musicogenic epilepsy with ictal asystole: a video‐EEG case report
Authors: Benoit Jeanne , Martin Florence , Thomas Pierre 
Published: July 2021

AbstractMusicogenic seizures and ictal asystole are two rare features mainly encountered in temporal lobe epilepsy. We present the first case of musicogenic epilepsy with ictal asystole in a patient with right temporal lobe epilepsy, confirmed by video‐EEG. The pathophysiological mechanism of both conditions remains uncertain. These two features appeared after many years of epilepsy in our patient, and although this association might be coincidental, common mechanisms could be involved, including remodelling of neural connections or seizure propagation to a singular zone. This case also highlights the need for precise electroclinical assessment of seizures that change clinically over time, particularly when falls occur after a certain period of latency, suggesting cardiac consequences of the seizures.
Factors affecting obesity in preadolescents: the case of Cappadocia
Authors: KOÇ Elif Tuba , ÇALIŞKAN Zehra , ERDEM Emine 
Published: July 2021

Purpose: This cross-sectional study was conducted to determine the risk factors which affect obesity in preadolescents.
Materials and Methods: The sample of the study consisted of 500 preadolescents (girls: n=271, boys: n=229) attended in 18 secondary schools in the Cappadocia region of Turkey, and their parents. Data were collected using a questionnaire, the body weight, height, and waist circumference of the preadolescents were measured; the body mass index (BMI) and the waist-to-height ratio were calculated.
Results: Of preadolescents; 14.4% were obese, 11.4% were overweight, 35.2% had abdominal obesity, and 27% had likehood of being at high metabolic and cardiovascular risk based on their waist/height ratio. According to the results of binary multiple logistic regression analysis (the backward stepwise procedure), the presence of an obese person in the family (boys), mother's educational level (girls), leisure time activities (girls), and an increase in eating according to mood (girls) were revealed as significant predictors of being overweight/obese, adjusted for age. Satisfied with current body weight and mother’s BMI were the strongest variable to be associated with overweight/obese for both genders.
Conclusion: For early diagnosis and prevention of obesity in childhood, it is recommended to perform height-weight monitoring of students regularly, monitor risky children more frequently, provide training and consultancy for students and parents regarding balanced diets and physical activity, and provide the school-family cooperation.
Evaluation of the oral dental health status of the Romani community in Turkey
Authors: KOÇAK Elif , ALKAYA Bahar 
Published: July 2021

Purpose: This study was conducted to determine the oral and dental health levels of individuals of a specific ethnic origin (Romani) living in Turkey and investigate its effects on quality of life.
Materials and Methods: The study was carried out in Adana (Yüreğir) between October 2018 and July 2019. Data were collected from 183 Romani individuals using face-to-face interview technique, an introductory information form, a form evaluating oral hygiene habits, and the Oral Health Impact Profile (OHIP) -14 scale. The number of dental caries, the number of missing teeth, and periodontal health levels, halitosis, and toothbrushing habits were evaluated by performing intraoral examinations of the participants.
Results: The OHIP-14 score of the individuals participating in the study showed a statistically significant change according to the number of missing teeth, the number of dental caries teeth, and brushing habits. Accordingly, the OHIP-14 score was observed higher in individuals with extracted teeth and decay in teeth. No statistically significant correlation was found between periodontal parameters and OHIP-14 scores.
Conclusion: Within the limitation of the study; It is thought that oral-dental health knowledge levels and oral hygiene habits should be increased in Romani individuals.
An analysis of the risks of COVID-19 exposure to hospital employees at a private hospital in Yogyakarta, Indonesia
Authors: Khairunnisa Qanita , Rosa Elsye Maria , Pribadi Firman , Ulfa Maria 
Published: July 2021

Background: The healthcare workers provide the services to reduce morbidity and mortality rates. However, they are also exposed directly to the patients. WHO reports that 88% of health workers were infected with COVID-19 while working in hospitals, and 17% got exposure from communities. This study analyzes the overview of risk exposure to COVID-19 and risk factors of COVID-19 exposure to hospital employees at a private hospital in Yogyakarta during the COVID-19 pandemic.Methods: This study employs a quantitative approach with a cross-sectional design study. The data collecting is using an online questionnaire to assess the risk of COVID-19 exposure toward healthcare workers. Results: From 101 employees who participated to be the respondent, 13 employees had been diagnosed with COVID-19 during work in the COVID-19 pandemic. There was a significant difference between IPC compliance with the incidence of COVID-19 (p=0.046). Meanwhile, there were no significant differences between comorbidity (p=0.205) and duration of work (p=0.125) with the incidence number of COVID-19. Based on the ANOVA analysis, there was no significant difference between; IPC compliance, comorbidity, and duration of work with the incidence number of COVID-19 (p=0.092). Conclusion: The risk of healthcare workers exposed to COVID-19 could be through various factors within and outside the hospital. Compliance with IPC, comorbidities, and duration of work only affect as much as 6.4% of the incidence of COVID-19 among hospital employees.
Could Primary Tumor Resection Improve Survival in Metastatic Breast Cancer?
Authors: Aparecida Dias de Oliveira Rafaela , Aparecida Dias de Oliveira Lyvia , Davoli Abella Goulart Marília , Faustino Linhares Maria Clara 
Published: July 2021

Introduction: In advanced breast cancer, local treatment is considered palliative. However, although there are some polemic opinions about the surgical treatment, some of the latest studies have emphasized that in advanced cases primary tumor resection (PTR) is related to better outcomes. This review aims to evaluate how resection of the original tumor impacts women with metastatic breast cancer, considering the most recent studies about this subject. Methods: The search was performed in MEDLINE, Scopus, PMC, Current Contents and Wiley Online Library databases; 23 articles - from 2016 to 2019 - were selected and 11 were included in this review. As inclusion criteria were considered: studies presenting outcomes about resection of the primary tumor, comparison between chemotherapy/ hormone therapy/ targeted cancer therapies and surgical intervention, studies published from 2016 to 2019 and available in English, Spanish or Portuguese. We excluded those which did not approach PTR, did not present outcomes of interest (progression-free survival comparison between PTR and systemic therapy) or only discussed systemic therapy, as well as those published before 2016. Results: It was reported in 6 studies that progression-free survival is better on those who underwent surgery. PTR was also related to longer median overall survival in women submitted to surgery, up to 16 months higher when compared to the ones who were not. Enhanced survival even pertained to surgical groups regardless of tumor size. Conclusion: Based in the analysis, PTR in metastatic breast cancer can be related to higher overall survival.
Authenticity, Self-Invention and the Power of Storytelling: Sam Shepard’s Postmillennial Work
Authors: Mirowska Paulina 
Published: July 2021

The article reflects upon Sam Shepard’s playwrighting in the opening decades of the twenty-first century, paying particular attention to his last play, A Particle of Dread (Oedipus Variations), written specifically for the Derry/Londonderry City of Culture celebrations in 2013, and originally produced by the renowned Field Day Theatre Company. The article seeks to offer an insight into Shepard’s mature multilayered text, which, in many respects, looks back upon almost fifty years of his artistic creativity and, at the same time, expands his vision. It also addresses the realisation of Shepard’s play in performance and the significance of his text in an interplay of multiple creative inputs involved in the production process.
While revisiting the familiar landscapes and themes, Shepard’s most recent work negotiates the boundaries between the actual and the fictitious, raising debates about the persistence of myths, mortality and the haunting legacies of the past. Richly intertextual and conspicuously metatheatrical, it grapples with questions of authenticity, performativity and storytelling – the narratives that are passed down, and how they form and inform our lives. It also engages with, and further problematises, issues of personal and cultural identity, which constitute Shepard’s most durable thematic threads, revealing both the dramatist’s acute concern with fateful determinism and commitment to self-invention. Significantly, while Shepard’s postmillennial output highlights the author’s ongoing preoccupation with instability and frontiers of various sorts (from those topographic, temporal and sociopolitical to those of language and art), it equally intimates his attentiveness to correspondences between times, lands and cultures.
​Diversity of Non-heterocystous Cyanobacteria in Paddy Field Soil
Authors: Rajasekaran Anitha , Raja Usha 
Published: July 2021

Paddy field soil is a natural habitat for many Cyanobacteria. Generally Heterocystous form dominate the nitrogen deficient soil. Non-heterocystous forms are also known to fix nitrogen. The diversity and the distribution of these forms vary. 20 Soil samples were serial diluted in BG-11 devoid of nitrogen supplement. Later the colonies were streaked to obtain axenic culture. The soil pH was also determined to study the effect on the diversity. The relative abundance of the BGA species was determined .Diversity of non-heterocystous form in the paddy field was found to be dominated by filamentous BGA, Lynbgya by 21%, Oscillatoria and Phormidium by 17% and colonial form Chrococcus sp by 12.5% Followed by Myxosarcina sp., 8%, while Aphanocapsa sp., Chlorogloea sp., Crinaluim sp., Gleocapsa sp, Plectonema sp. and Schizothrix sp., were 4%. A majority of the non-heterocystous BGA were found in the soil which had a pH ranging between 8.2-8.6. Diversity study of non-heterocystous BGA can help in understanding the distribution and further aid in the study of nitrogen fixation in these forms.
​Fuzzy Logic Expert System for Taxonomic Variation of Solonchaks
Authors: Hadj-Miloud Samir , Djili Kaddour 
Published: July 2021

Background: The main objective of this research is to apply fuzzy logic to four Solonchaks, in order to determine their degree of remoteness or rapprochement with their central taxonomic concept. Therefore, we identify their possible seasonal taxonomic variation on the criteria established by World Reference Base (WRB). Methods: We have studied the seasonal evolution of salinity in a region of Algeria (Case of Rélizane), during two years 2012 and 2013 by applying fuzzy logic on the four soils. Result: The results reveal that the salinity increased during the dry period for all soils and it decreased during the wet period. On the taxonomic level, the application of fuzzy logic on the four soils revealed that the Solonchaks indices (Is) are always significantly higher than those of Calcisols indices (Ic). The four profiles have a similar behavior regarding the variation of Is. Indeed, when the salinity increases the soils come closer to the central taxonomic concept of the Solonchaks. Likewise, when the salinity decreases the soils move away from their central taxonomic concept. Consequently, they approach the central taxonomic concept of Calcisols. Thus, the variation of Isis closely related to the seasonal variation of salinity. Fuzzy logic, exhibited high precision concerning the membership value between soils over time. The application of fuzzy logic for other soil classifications in the world is possible.
PENGARUH EXERCISE INTENSITAS TINGGI TERHADAP KETEBALAN ENDOMETRIUM MENCIT (MUS MUSCULUS)
Authors: Yuli Aizah Ari Setyana , Sari Gadis Meinar , Sa’adi Ashon 
Published: July 2021

Abstrak Latar Belakang : Exercise dapat menyebabkan terbentuknya reactive oxygen species (ROS). Ketidakseimbangan antara antioksidan endogen dan ROS dapat menyebabkan stres oksidatif. Stres oksidatif dapat menyebabkan infertilitas pada wanita melalui berbagai mekanisme. Endometrium yang tidak sempurna karena ROS tidak dapat mendukung embrio dan perkembangannya. Penelitian ini bertujuan untuk menganalisa perbedaan ketebalan endometrium pada mencit yang exercise intensitas tinggi. Metode : Penelitian ini true experimental dengan rancangan randomized posttest only design. Besar sampel adalah 7 ekor tiap kelompok, yang terdiri dari 2 kelompok. Kelompok kontrol dan kelompok exercise intensitas tinggi. Data yang didapatkan adalah ketebalan endometrium mencit. Hasil : hasil uji mann-whitney menunjukkan hasil yang signifikan dengan P=0,006. Kesimpulan : exercise intensitas tinggi dapat mempengaruhi ketebalan endometrium.. Abstract Background: Reactive Oxygen Species (ROS) is formed by exercise. Oxidative stress is caused by an imbalance between endogenous antioxidants and ROS. Oxidative stress causes infertility in women through mechanisms. Because of ROS, endometrium can not support the embryo and its development. This research aim to analyze different of endometrial thickness mice with high intensity exercise. Methods: This research is true experimental researh with randomized posttest only design. The sample size is 7 female mice each group, devided into 2 groups. The control group, and the high-intensity exercise group. Data obtained from mice endometrial thickness Results: mann-whitney gave significant result at level p=0.006. Conclusion: high intensity exercise can effect the thickness of the endometrium.