bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antidepressant Activity of Nardostachys jatamansi Extract in Animal Models of Depression
Authors: Saleem Faraz , Ismail Muhammad Owais , Memon Zahida , Arif Faraz 
Published: January 2021

Background: Depression refers to a wide range of mental health problems characterized by the loss of interest in routine activities, low mood and a range of associated emotional, cognitive, physical and behavioral symptoms. It is one of the major causes of mortality as tendency of suicidal attacks are exhibited in these patients. The diagnosis of depressive patients is very complicated in many cases and they do not respond to rational clinical prescription. In traditional medicine, Nardostachys jatamansi has been used as stimulant, antispasmodic, laxative and antiepileptic in ayurvedic and unani systems of medicine. The objective of our study was to evaluate and compare the antidepressant activity of N. jatamansi extract with fluoxetine in animal models of depression.
Methodology: It was a preclinical experimental study in which Total 100 BALB/c mice divide into 14 groups i.e. Group 1 & 2 control 0.9% NaCl i.p for forced swimming test (FST) and tail suspension test (TST) respectively, Group 3 & 4 Fluoxetine 0.5 mg/kg i.p for FST and TST respectively, Group 5, 6 & 7 of N. jatamansi 125, 250 and 500 mg/kg respectively for FST, Group 8, 9 & 10 N. jatamansi 125, 250 and 500 mg/kg respectively for TST, Group 11 N. jatamansi (most effective dose) for Locomotor Test, Group 12 NaCl 0.9% for Yohimbine Potentiation Test (YPT), Group 13 Fluoxetine 0.5 mg/kg for YPT and Group 14 Received extract of N. jatamansi (most effective dose) for YPT. Antidepressant activity of N. jatamansi extract at different doses after induction of depression via FST and TST was recorded. Moreover the antidepressant effect was confirmed by locomotor test. YPT was also applied to comment on possible underlying mechanism.
Results: In our study 250 mg/kg and 500 mg/kg doses of N. jatamansi showed significant reduction in immobility time when compared to controls and 500 mg/kg showed significant reduction as compared to group given fluoxetine in FST model. All the groups in TST model showed significant reduction in immobility time when compared to controls and fluoxetine given group. N. jatamansi at the dose of 500 mg/kg was found to be most effective in both the models. No significant change in locomotor activity was found in locomotor test. The percentage mortality of 50% was observed in N. jatamansi group using yohimbine potentiation test.
Conclusion: In our study Nardostachys jatamansi showed significant reduction in immobility time when compared to controls and fluoxetine.
Rasmussen’s encephalitis with persistent epilepsy in a young man
Authors: Hoang Van Trung , Nguyen Thanh Tam Thi , Vo Nhu Quynh , Chansomphou Vichit , Trinh Cong Thao 
Published: January 2021

AbstractRasmussen's encephalitis (RE) is an uncommon cause of the seizure. Important key findings of RE include intractable seizure activity in children, progressive atrophy of the involved hemisphere, and small hemisphere with the large ventricle.
Karplus relationships of the 2JHNα and 3JΗΝβ couplings in organic azides
Authors: Navarro‐Vázquez Armando , Pennestri Matteo 
Published: January 2021

AbstractDensity functional theory (DFT) and second‐order polarization propagator approximation (SOPPA) computations in model organic azides revealed a Karplus‐like dependence not only of the vicinal 3JH–C–Nα–Nβ coupling but also of the geminal 2JH–C–Nα one, with the H–C–NαNβ dihedral angle. Karplus equations were derived from the DFT computations on the isopropylazide model system. In light of these stablished relationships, natural abundance 1H–15N couplings obtained for the azide group of the zidovudine antiviral helped to probe its conformation around the C–Nα bond as being of the synclinal type.
Kutanes Angiosarkom mit klinischem Bild eines Quincke-Ödems
Authors: Albrecht M. , Hadaschik E. , Zimmer L. , Livingstone E. , Hamacher R. , Bauer S. , Schadendorf D. , Ugurel S. 
Published: January 2021

ZusammenfassungEs wird über den Fall eines 75-jährigen Patienten mit einer Gesichtsschwellung v. a. periorbital berichtet, der unter der Verdachtsdiagnose eines Quincke-Ödems stationär aufgenommen wurde. Probebiopsien ergaben das Vorliegen eines kutanen Angiosarkoms. Bei nicht resezierbarem Befund und schwieriger Bestrahlungssituation wurde zunächst eine Chemotherapie eingeleitet. Im Verlauf erfolgte bei Befundprogress die Therapieumstellung auf Zweit- und Drittlinientherapie. Der geschilderte Fall verdeutlicht die Komplexität bei der Diagnostik und Therapie bei Patienten mit kutanem Angiosarkom.
Lack of association between proton pump inhibitor use and brain aging: a cross-sectional study
Authors: Ahn Nayeon , Frenzel Stefan , Wittfeld Katharina , Bülow Robin , Völzke Henry , Lerch Markus M. , Chenot Jean-Francois , Schminke Ulf , Nolde Michael , Amann Ute , Meisinger Christa , Linseisen Jakob , Baumeister Sebastian E. , Grabe Hans Jörgen , Rückert-Eheberg Ina-Maria 
Published: January 2021

AbstractPurposeDue to conflicting scientific evidence for an increased risk of dementia by intake of proton pump inhibitors (PPIs), this study investigates associations between PPI use and brain volumes, estimated brain age, and cognitive function in the general population.MethodsTwo surveys of the population-based Study of Health in Pomerania (SHIP) conducted in Northeast Germany were used. In total, 2653 participants underwent brain magnetic resonance imaging (MRI) and were included in the primary analysis. They were divided into two groups according to their PPI intake and compared with regard to their brain volumes (gray matter, white matter, total brain, and hippocampus) and estimated brain age. Multiple regression was used to adjust for confounding factors. Cognitive function was evaluated by the Verbal Learning and Memory Test (VLMT) and the Nuremberg Age Inventory (NAI) and put in relation to PPI use.ResultsNo association was found between PPI use and brain volumes or the estimated brain age. The VLMT score was 1.11 lower (95% confidence interval: − 2.06 to − 0.16) in immediate recall, and 0.72 lower (95% CI: − 1.22 to − 0.22) in delayed recall in PPI users than in non-users. PPI use was unrelated to the NAI score.ConclusionsThe present study does not support a relationship between PPI use and brain aging.
Long-term psychosocial outcome following mild traumatic brain injury and minor stroke: a direct longitudinal comparison
Authors: Verberne Daan P. J. , Ponds Rudolf W. H. M. , Kroese Mariëlle E. A. L. , Wijenberg Melloney L. M. , Barten Dennis G. , Pasmans Raphaël , Staals Julie , van Heugten Caroline M. 
Published: January 2021

Abstract
Background and purpose
Research suggests comparable long-term psychosocial outcomes following mild traumatic brain injury (mTBI) and minor stroke, but no direct comparison has been made. This study aimed to directly compare psychosocial outcome over time in persons with mTBI and minor stroke.

Methods
In this multicenter, prospective longitudinal cohort study, community-dwelling persons with mTBI (n = 182) and minor stroke (n = 48) were assessed at 6 weeks, 3, 6 and 12 months post-injury. Outcome measures included anxiety and depression symptoms (Hospital Anxiety and Depression Scale—HADS), cognitive problems in daily life (Checklist for Cognitive and Emotional Consequences of Stroke—CLCE-24) and quality of life (EuroQol-5D-5L—EQ-5D-5L). Multilevel growth curve modeling, controlled for demographic variables, was used to determine outcomes over time between groups. Proportions of persons reporting persistent psychosocial symptoms at 6 months post-injury were compared using Pearson’s Chi-squared tests.

Results
Improvements in outcomes were observed in the first 6 months and effects stabilized to 12 months post-injury in both groups. Minor stroke cases reported significantly higher levels of HADS anxiety and a significantly reduced increase in EQ-5D-5L utility scores than mTBI cases, but differences were small in absolute numbers. No significant differences were observed between groups regarding HADS depression and CLCE-24 cognition scores. Proportions of persons reporting persistent psychosocial symptoms were equal between groups.

Conclusions
Psychosocial outcome is largely comparable following mTBI and minor stroke. Specific attention should be paid to anxiety symptoms and cognitive problems in daily life for which uniform aftercare seems appropriate.
Prevalence and treatment of retrograde peri-implantitis: a retrospective cohort study covering a 20-year period
Authors: Di Murro Bianca , Canullo Luigi , Pompa Giorgio , Di Murro Carlo , Papi Piero 
Published: January 2021

Abstract
Objectives
The aims of this retrospective study were to report data on the prevalence of retrograde peri-implantitis (RPI) in a single-center in a 20-year observation period and to evaluate implant survival after surgical treatment.

Materials and methods
A retrospective cohort study was conducted screening all patients who underwent implant treatment in a private practice. Patients were enrolled if they had one or more implants showing a radiolucency around the implant apex, without implant mobility. Furthermore, clinical symptoms of RPI and days from symptoms’ appearance after implant placement were also collected, as well as periodontal and endodontic status of nearby teeth. All patients were treated with the same surgical approach: antibiotic therapy, mechanical curettage, chemical decontamination and xenograft application.

Results
Out of the 1749 implants placed, only 6 implants were classified as affected by RPI, with a prevalence of 0.34%. Clinical symptoms of RPI (pain, swelling, dull percussion or fistula presence) varied among patients and were reported after a mean period of 51.83 ± 52.43 days.

Conclusions
RPI was successfully treated with surgical curettage and bone substitute application and all implants are still in place after a mean follow-up of 8.83 ± 5.34 years.

Clinical relevance
Bacteria from teeth with failed endodontic treatment or residual lesions might be reactivated by drilling for implant osteotomy, with subsequent colonization of the implant apex and possible failure before prosthetic loading. Therefore, it might be recommended to take a periapical x-ray at implant placement and after 6–8 weeks in order to intercept RPI before prostheses delivery.
Elastic deformation of the mandibular jaw revisited—a clinical comparison between digital and conventional impressions using a reference
Authors: Schmidt Alexander , Klussmann Leona , Schlenz Maximiliane A. , Wöstmann Bernd 
Published: January 2021

Abstract
Objectives
Due to the partly strongly differing results in the literature, the aim of the present study was to investigate a possible deformation of the mandible during mouth opening using an intraoral scanner (IOS) and a conventional impression for comparison with a reference aid.

Materials and methods
Four steel spheres were reversibly luted in the mandibular (n = 50) with a metallic reference aid at maximum mouth opening (MMO). Two digital impressions (Trios3), at MMO and at slightly mouth opening SMO and a conventional impression (Impregum), were taken as the measuring accuracy of the reference structure was already known. Difference between MMO-SMO for digital impressions and deviations between digital and conventional (SMO) were calculated. Furthermore, the angle between the normal vectors of two constructed planes was measured. Statistical analysis was performed with SPSS25.

Results
Deviations for linear distances ranged from −1 ± 3 μm up to 17 ± 78 μm (digital impressions, MMO-SMO), from 19 ± 16 μm up to 132 ± 90 μm (digital impressions, SMO), and from 28 ± 17 μm up to 60 ± 52 μm (conventional impressions, SMO). There were no significant differences for digital impressions (MMO-SMO), and there were significant differences between the conventional and digital impressions at SMO.

Conclusions
Based on the results of the present study, no mandibular deformation could be detected during mouth opening with regard to the digital impressions. The results were rather within the measuring tolerance of the intraoral scanner.

Clinical relevance
Based on the present study, no deformation of the mandibular during mouth opening could be observed at the level previously assumed. Therewith related, dental techniques related to a possible mandibular deformation therefore should be reconsidered.
Quantum Graphs as Quantum Relations
Authors: Weaver Nik 
Published: January 2021

AbstractThe “noncommutative graphs” which arise in quantum error correction are a special case of the quantum relations introduced in Weaver (Quantum relations. Mem Am Math Soc 215(v–vi):81–140, 2012). We use this perspective to interpret the Knill–Laflamme error-correction conditions (Knill and Laflamme in Theory of quantum error-correcting codes. Phys Rev A 55:900-911, 1997) in terms of graph-theoretic independence, to give intrinsic characterizations of Stahlke’s noncommutative graph homomorphisms (Stahlke in Quantum zero-error source-channel coding and non-commutative graph theory. IEEE Trans Inf Theory 62:554–577, 2016) and Duan, Severini, and Winter’s noncommutative bipartite graphs (Duan et al., op. cit. in Zero-error communication via quantum channels, noncommutative graphs, and a quantum Lovász number. IEEE Trans Inf Theory 59:1164–1174, 2013), and to realize the noncommutative confusability graph associated to a quantum channel (Duan et al., op. cit. in Zero-error communication via quantum channels, noncommutative graphs, and a quantum Lovász number. IEEE Trans Inf Theory 59:1164–1174, 2013) as the pullback of a diagonal relation. Our framework includes as special cases not only purely classical and purely quantum information theory, but also the “mixed” setting which arises in quantum systems obeying superselection rules. Thus we are able to define noncommutative confusability graphs, give error correction conditions, and so on, for such systems. This could have practical value, as superselection constraints on information encoding can be physically realistic.
Experimental investigations of spray flow rate and angle in enhancing the performance of PV panels by steady and pulsating water spray system
Authors: Nateqi Mojtaba , Rajabi Zargarabadi Mehran , Rafee Roohollah 
Published: January 2021

AbstractIn this study, a spray cooling system is experimentally investigated to increase the photovoltaic panel efficiency. Cooling of photovoltaic panels is one of the important parameters that affects the PV panel performance. In this experiment the effects of spray angle, nozzles to PV panel distance, number of nozzles, and pulsating water spray on the PV panel performance are investigated. For this purpose, an experimental setup was made. The spray angles varied from 15° to 50°. The comparison between the spray angles shows that by decreasing the spray angle to 15° increases the electrical efficiency of PV panel to 19.78% and simultaneously the average PV panel temperature decreases from 64 (for non-cooled PV) to 24 °C. Also, nozzle to PV panel distance was changed from 10 to 50 cm. The best result was obtained for the lowest distance by 25.86% increase in power output. Study of various frequency also show that due to the surface evaporation and the intensity of the radiation, increasing the water spraying frequency can increase or decrease the electrical efficiency. The On–Off water spray system results show that the maximum increase in efficiency was obtained with frequency of 0.2 Hz which it was 16.84%. Water consumption also decreased to half.
Improving the External Validity of Conjoint Analysis: The Essential Role of Profile Distribution
Authors: de la Cuesta Brandon , Egami Naoki , Imai Kosuke 
Published: January 2021

AbstractConjoint analysis has become popular among social scientists for measuring multidimensional preferences. When analyzing such experiments, researchers often focus on the average marginal component effect (AMCE), which represents the causal effect of a single profile attribute while averaging over the remaining attributes. What has been overlooked, however, is the fact that the AMCE critically relies upon the distribution of the other attributes used for the averaging. Although most experiments employ the uniform distribution, which equally weights each profile, both the actual distribution of profiles in the real world and the distribution of theoretical interest are often far from uniform. This mismatch can severely compromise the external validity of conjoint analysis. We empirically demonstrate that estimates of the AMCE can be substantially different when averaging over the target profile distribution instead of uniform. We propose new experimental designs and estimation methods that incorporate substantive knowledge about the profile distribution. We illustrate our methodology through two empirical applications, one using a real-world distribution and the other based on a counterfactual distribution motivated by a theoretical consideration. The proposed methodology is implemented through an open-source software package.
U-TEST, a simple decision support tool for the diagnosis of sarcopenia in orthopaedic patients: the Screening for People Suffering Sarcopenia in Orthopedic cohort of Kobe study (SPSS-OK)
Authors: Kamitani Tsukasa , Wakita Takafumi , Wada Osamu , Mizuno Kiyonori , Kurita Noriaki 
Published: January 2021

AbstractWe aimed to develop and validate a new simple decision support tool (U-TEST) for diagnosis of sarcopenia in orthopaedic patients. We created seventeen candidate original questions to detect sarcopenia in orthopaedic patients with sarcopenia through expert opinions and a semi-structured interview. To derive a decision support tool, a logistic regression model with backward elimination was applied to select variables from the seventeen questions, age and underweight (BMI < 18·5 kg/m2). Sarcopenia was defined by Asian Working Group for Sarcopenia 2019 criteria. After assigning a score to each selected variable, the sum of scores was calculated. We evaluated the diagnostic performance of the new tool using a logistic regression model. A bootstrap technique was used for internal validation. Among a total of 1334 orthopaedic patients, sixty-five (4·9 %) patients were diagnosed with sarcopenia. We succeeded in developing a ‘U-TEST’ with scores ranging from 0 to 11 consisting of values for BMI (Underweight), age (Elderly) and two original questions (‘I can’t stand up from a chair without supporting myself with my arms’ (Strength) and ‘I feel that my arms and legs are thinner than they were in the past’ (Thin)). The AUC was 0·77 (95 % CI 0·71, 0·83). With the optimal cut-off set at 3 or greater based on Youden’s index, the sensitivity and the specificity were 76·1 and 63·6 %, respectively. In orthopaedic patients, our U-TEST scoring with two questions and two simple clinical variables can help to screen for sarcopenia.
Using manure for improving nitrogen fertilization and maize yield
Authors: Jia Xucun , Yang Qinglong , Dong Shu-Ting , Zhang Ji-Wang , Zhao Bin , Liu Peng 
Published: January 2021

AbstractManure and chemical fertilizers have different effects on soil properties, the nitrogen cycle, and crop yield. This study aimed to investigate the effects of different fertilizer applications under the same N input on soil physicochemical properties and soil bacterial communities and to explain the contributions of soil properties to grain yield. Manure substitution of chemical fertilizer was conducted in leaching monitoring systems. The study began in 2009 and sampling was carried out in 2014 and 2016. Three fertilizer treatments with the same total N, P, and K application rates and one control treatment were designed as follows: (1) CK, without nitrogen fertilizer; (2) 100%U, whole nitrogen coming from urea; (3) 100%M, whole nitrogen coming from composted cattle manure; and (4) 50%U + 50%M, half nitrogen from composted cattle manure and half nitrogen from urea. Soil organic carbon (SOC) content was positively correlated with total N (TN), NO3−–N, and NH4+–N contents, the mean weight diameter of soil aggregates, and the Shannon diversity index of bacteria, whereas SOC content was not significantly correlated with grain yield. NO3−–N content was positively correlated with grain yield. Substituting half the amount of chemical fertilizer with manure as a nitrogen source improved soil stability, increased bacterial diversity, and enhanced nitrogen supply, while reducing nitrogen loss from ammonia volatilization and nitrogen leaching. Substituting half the amount of chemical fertilizer with manure as a nitrogen source was a more sustainable way to increase grain yield through a sustainable nitrate supply and to reduce N loss.
The Fractured Centre: ‘Two-headed government’ and threats to the peace process in Myanmar
Authors: THAWNGHMUNG ARDETH MAUNG , HTOO SAW EH 
Published: January 2021

AbstractThis article analyses the evolving nature and dynamics of the relationship between the centre and the periphery by examining how semi-democratic reforms have shaped and influenced the peace negotiation process between the government and ethnic armed organizations (EAOs) since 2011. We demonstrate that while the 2008 constitution has reduced restrictions on political, economic, and cultural activities in Myanmar, it has also inevitably produced a ‘two-headed government’ after the main opposition party, the National League for Democracy (NLD), took charge in 2016 and was forced to share power with the military. This ‘two-headed’ government is the result of the historical distrust between the NLD and the army, combined with the NLD's lack of a clear strategy in dealing with EAOs. This has enabled the army to assert its well-articulated and hardline approach—without itself having an effective strategy or the capacity to end the country's armed insurgencies or bring the peace process forward. We show that the split at the centre has produced inertia and weakened the ability of the central government to formulate and implement effective policy, and further undermined the prospects for national reconciliation. Situating this case study within the wider literature of centre–periphery relationships and democratic transition, this article offers a nuanced and comprehensive analysis of how specific institutional arrangements at the centre in semi-democratic settings affect relations in both the centre and the periphery, as well as centre–periphery relationships.
Assessing colonies of Antarctic shags by unmanned aerial vehicle (UAV) at South Shetland Islands, Antarctica
Authors: Pfeifer Christian , Rümmler Marie-Charlott , Mustafa Osama 
Published: January 2021

AbstractDue to the remote location of colonies of Antarctic shags (Phalacrocorax(atriceps)bransfieldensis) in Antarctica, there is only sparse data on the abundance of this species. An unmanned aerial vehicle (UAV) survey for known and unknown Antarctic shag colonies along the coasts of Nelson Island and western King George Island, Antarctica, was conducted in December 2016. Four colonies, one of them previously unknown, were detected. For the first time since the 1980s, the total population size of the colonies in that area was determined. A comparison with previous estimates revealed evidence of a population increase by a factor of 2.86. To support future survey campaigns, several characteristic features of Antarctic shag colonies, nests and individuals in aerial imagery were identified. This makes possible more reliable detection and determination of population size in Antarctic shag colonies. These characteristic features were compared with those of chinstrap penguin colonies (Pygoscelis antarcticus) because these species often overlap spatially and are difficult to distinguish. In addition, the optimal weather conditions and flight parameters for an aerial survey were specified.