bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regression of portal hypertension: underlying mechanisms and therapeutic strategies
Authors: Selicean Sonia , Wang Cong , Guixé-Muntet Sergi , Stefanescu Horia , Kawada Norifumi , Gracia-Sancho Jordi 
Published: February 2021

AbstractPortal hypertension is the main non-neoplastic complication of chronic liver disease, being the cause of important life-threatening events including the development of ascites or variceal bleeding. The primary factor in the development of portal hypertension is a pathological increase in the intrahepatic vascular resistance, due to liver microcirculatory dysfunction, which is subsequently aggravated by extra-hepatic vascular disturbances including elevation of portal blood inflow. Evidence from pre-clinical models of cirrhosis has demonstrated that portal hypertension and chronic liver disease can be reversible if the injurious etiological agent is removed and can be further promoted using pharmacological therapy. These important observations have been partially demonstrated in clinical studies. This paper aims at providing an updated review of the currently available data regarding spontaneous and drug-promoted regression of portal hypertension, paying special attention to the clinical evidence. It also considers pathophysiological caveats that highlight the need for caution in establishing a new dogma that human chronic liver disease and portal hypertension is reversible.
Psychophysics Experiment to Check the Temperature Impacts Over Human Fingertips for the Application of Textural Applications in Haptics Technology
Authors: Ravikanth Dadi , Hariharan P. 
Published: February 2021

AbstractPsychophysical methods in haptic technology help in comparative study and eventually be a data set to achieve realism over skin sensation. Textural based haptic applications are widely developed using tactile displays over human fingertips. The tactile displays work on open-loop admittance feedback system and are controlled with flexible parameters by ignoring the impact of noise or disturbance variables. Human skin undergoes various noise factors like temperature, humidity, sweat, and influence of alternative senses. This paper presents the newly adopted method of psychophysics to study the influence of environmental conditions over perceiving textural surfaces. The paper adopts the detection mode of psychophysics which uses perception time as an output parameter for understanding perception memory of the human skin. We have recorded the period of the perception in three environmental conditions over human subjects under a single blindfold method to study the behaviour of human skin at fingertips. The perception time of stimulus is analysed with arithmetic average roughness value (Ra) to understand the tolerance factor required during tactile based textural applications. The proposed method is simple to structure and improves in creating the dataset required to consider the noise factor for an open-loop admission feedback system.
Lived body and the Other’s gaze: a phenomenological perspective on feeding and eating disorders
Authors: Mancini Milena , Esposito Cecilia Maria 
Published: February 2021

AbstractAccording to the phenomenological perspective, the lived body disorder is a core feature of feeding and eating disorders (FEDs). Persons with FEDs experience their own body first of all as an object looked by another person, rather than coenaesthetically or from a first-person perspective. In particular, the main features of this disorder are: alienation from the own body and from the own emotions, disgust for it, shame, and an exaggerated preoccupation for the way in which one appears to the others. Phenomenological research has recently highlighted that the gaze of the Other plays an important role. Because persons with FEDs cannot have an experience of their own body from within or coenesthetically, they need to apprehend their own body from outside through the gaze of the Other. This way of apprehending one’s own body when it is looked by another person is called by Sartre the ‘lived body-for-others’. Normally, the constitution of one’s own body, and consequently of one’s own Self and identity depends on the dialectic integration between the first-person apprehension of one’s body (lived body) that it is based on coenaesthesia, and the third-person one, that it is based on the sense of sight (lived-body-for-others). When the dialectic is unbalanced toward the pole of the lived-body-for-others, experienced from without, the symptom occurs. Starting from these clinical observations, the so-called Optical-Coenaesthetic Disproportion model has been developed. In this paper, we describe this model, its philosophical and clinical foundations, and finally its clinical implication and its relationship with other disciplines, i.e., neurosciences. Level of evidence: V.
Experimental and numerical study of coal-rock bimaterial composite bodies under triaxial compression
Authors: Chen Yulong , Zuo Jianping , Liu Dejun , Li Yingjie , Wang Zhenbo 
Published: February 2021

AbstractTo accurately predict coal burst hazards and estimate the failure of coal pillars in underground coal mining systems, it is of great significance to understand the mechanical behavior of coal-rock bimaterial composite structures. This paper presents experimental and numerical investigations on the response of rock-coal, coal-rock, and rock-coal-rock bimaterial composite structures under triaxial compression. The triaxial compression experiments are conducted under confining pressures in the range of 0–20 MPa. The resulting inside fracture networks are detected using X-ray-based computed tomography (CT). The experimentally observed data indicate that the mechanical parameters of the rock-coal-rock composites are superior to those of the rock-coal and coal-rock combinations. After compression failure, the coal-rock combination specimens are analyzed via X-ray CT. The results display that the failure of the coal-rock composite bodies primarily takes place within the coal. Further, the bursting proneness is reduced by increasing confining pressure. Subsequently, the corresponding numerical simulations of the experiments are carried out by using the particle flow code. The numerical results reveal that coal is vulnerable with regard to energy storage and accumulation.
Effects of different ventilation on cerebral oxygen saturation and cerebral blood flow before and after modified ultrafiltration in infants during ventricular septal defect repair
Authors: Cui Boqun , Ou-Yang Chuan , Xie Siyuan , Lin Duomao , Ma Jun 
Published: February 2021

AbstractObjective:To analyse the changes of different ventilation on regional cerebral oxygen saturation and cerebral blood flow in infants during ventricular septal defect repair.Methods:Ninety-two infants younger than 1 year were enrolled in the study. End-expiratory tidal pressure of carbon dioxide was maintained at 40–45 and 35–39 mmHg in relative low and high ventilation groups. Regional cerebral oxygen saturation and flow velocity of the middle cerebral artery were recorded after anaesthesia (T0), cut pericardium (T1), separation from cardiopulmonary bypass (T2), the end of modified ultrafiltration, (T3) and at the end of operation (T4).Results:The relative low ventilation group exhibited a significantly high regional cerebral oxygen saturation at each time point except for T2 (T0:77 ± 4, T1:76 ± 5, T3:76 ± 8, T4:76 ± 8, respectively, p < 0.001). Flow velocity of the middle cerebral artery in the relative low ventilation group was higher compared to the relative high ventilation group at each time point except for T2 (T0:53 ± 14, T1:54 ± 15, T3:53 ± 17, T4:52 ± 16, respectively, p < 0.001). Between the two groups, T2 showed the lowest middle cerebral artery flow velocity (relative low ventilation: 39 ± 15, relative high ventilation: 39 ± 11, p < 0.001).Conclusion:The infants’ regional cerebral oxygen saturation and middle cerebral artery flow velocity performed better in the range of 40–45 mmHg end-expiratory tidal pressure of carbon dioxide during CHD surgery. Modified ultrafiltration increased cerebral oxygen saturation. It was important to regulate ventilation in order to balance cerebral oxygen in infants.
A structured expert judgement elicitation approach: how can it inform sound intervention decision-making to support household food security?
Authors: Kleve Sue , Barons Martine J 
Published: February 2021

AbstractObjective:To examine structured expert judgement (SEJ) elicitation as a method to provide robust, defensible data for three determinants of household food security (food cost, household disposable income and physical access) for quantifying a proof-of-concept integrating decision support system for food security.Design:SEJ elicitation is a validated method for obtaining unavailable data, but its use in household food security in high-income countries is novel. Investigate Discuss Estimate Aggregate (IDEA) elicitation protocol was implemented, including quantitative and qualitative elements. Using specific questions related to three determinants, food security experts were encouraged to Investigate – estimate individual first-round responses to these questions, Discuss – with each other evidence on the reasoning and logic of their estimates, Estimate – second-round responses, following which these judgements were combined using mathematical Aggregation.Setting:Victoria, Australia.Participants:Five experts with a range of expertise in the area of household food insecurity participated in the SEJ elicitation process.Results:The experts’ ability to provide reliable estimates was tested and informed the aggregation of the collection of individual estimates into a single quantity of interest for use in decision support. The results of the quantitative elicitation show the impact of combinations of varying household income, food cost and physical access on household food security status and severity and is supported by the experts reasoning during elicitation.ConclusionThis research provides insight to the application of SEJ where elicited data can inform and support intervention decision-making specific to household food security, especially where evidence is absent or of poor quality.
Hygroscopicity of Organic Aerosols Linked to Formation Mechanisms
Authors: Liu Jieyao , Zhang Fang , Xu Weiqi , Sun Yele , Chen Lu , Li Shangze , Ren Jingye , Hu Bo , Wu Hao , Zhang Renyi 
Published: February 2021

AbstractOrganic aerosols (OAs) account for a large fraction of tropospheric fine particulate matter, but the hygroscopicity of OA is poorly understood. Here, we show remarkably‐enhanced water uptake capacity of OA due to formation of highly‐oxidized oxygenated OA on new particle formation (NPF) events in Beijing. While non‐nucleation processes also produce oxidized OA, their hygroscopicity exhibits little enhancement. As a result, a correlation between the hygroscopicity and oxidation state is absent for OA on non‐NPF days. Further analysis reveals that the highly‐oxidized oxygenated OA is 2.5 and 5‐fold as hygroscopic as the oxidized primary OA and less‐oxidized oxygenated OA, respectively. Our results suggest that nucleation‐initiated photooxidation of volatile organic compounds to produce water‐soluble organic acids may dominate on NPF days, and the aqueous oligomerization to yield less water‐soluble products might occur on non‐NPF days.
Investigating the Development of Distinctive Subauroral Flow Channels During the November 7–8, 2004 Superstorm
Authors: Horvath Ildiko , Lovell Brian C. 
Published: February 2021

AbstractWe investigate the development of large (∼3,000 m/s) subauroral flows occurring during the November 7–8, 2004 Superstorm by utilizing multisatellite and multiinstrument measurements from the Magnetosphere (M), topside Ionosphere (I), and Thermosphere (T). We present eight scenarios (Sc‐1–Sc‐8) depicting the development of large SubAuroral Polarization Streams (SAPS) in the initial phase (Sc‐1–Sc‐3) and recovery phase (Sc‐5), and structured SAPS (Sc‐4, Sc‐6–Sc‐7) and Double‐peak SubAuroral Ion Drifts (DSAID) in the recovery phase (Sc‐8). Magnetospheric observations reveal dayside magnetopause reconnection increasing both the magnetospheric convection electric field and the large‐scale Field‐Aligned Currents (FACs), long‐lasting (∼5 h) secondary dipolarizations during the initial phase, and a series of dipolarization events during the recovery phase. Ionospheric observations reveal the development of these large subauroral flows (i) during forward and reverse plasma convections—when the topside ionosphere received earthward energy from the magnetosphere and when the diversion of cross‐tail currents in the stretched magnetotail activated the Substorm Current Wedge (SCW)—and (ii) in a short‐circuited system that acted as a voltage generator. Thermospheric observations reveal earthward energy deposition from the ionosphere that drove wind surges—implying the presence of Atmospheric Gravity Waves (AGWs) and Traveling Ionospheric Disturbances (TIDs)—propagating equatorward/poleward and passing through the trough region, and further enhancing the subauroral flows by deepening the trough. From these results we conclude that the strong M‐I‐T coupling occurring under superstorm conditions played a significant role in the enhancement of the subauroral flows investigated.
Inverse Migration of Seismicity Quiescence During the 2019 Ridgecrest Sequence
Authors: Marsan D. , Ross Z. E. 
Published: February 2021

AbstractSeismicity quiescences are best observed during sequences with multiple mainshocks and often emerge with some delay after an initial phase of aftershock triggering. The mechanisms controlling this delay are poorly understood, due to a lack of systematic and precise estimation of the duration of the triggering phase which is made complicated by the rapidly changing magnitude of completeness after the mainshock. Here, we analyze how such a delayed quiescence developed during the 2019 Ridgecrest (California) sequence, using a refined earthquake data set obtained by template matching and relative relocation. A method that allows estimating the aftershock occurrence rate after correcting for the change in detection (completeness magnitude) is applied. We find that an immediate seismicity shutdown was triggered by the second (M7.1) mainshock at the tips of the north‐east trending cross‐cut fault that hosted most of the slip of the first (M6.4) mainshock. This shutdown progressed toward the central part of this fault over the following days. The overall shutdown of the aftershock sequence of the M6.4 by the M7.1 rupture is consistent with static Coulomb stress modeling. This inverse migration is a unique observation, best explained by an enhanced spatial stress change variability in this central part where the cross‐cut fault intersects the main fault of the M7.1 shock, hence a strongly damaged zone there. This further confirms previous observations of an enhanced structural disorder in this central part of the cross fault, showing that structural disorder has a first‐order control on the seismicity dynamics at the scale of days.
Leveraging Uncertainty Quantification to Design Ocean Climate Observing Systems
Authors: Loose Nora , Heimbach Patrick 
Published: February 2021

AbstractOcean observations are expensive and difficult to collect. Designing effective ocean observing systems therefore warrants deliberate, quantitative strategies. We leverage adjoint modeling and Hessian uncertainty quantification (UQ) within the ECCO (Estimating the Circulation and Climate of the Ocean) framework to explore a new design strategy for ocean climate observing systems. Within this context, an observing system is optimal if it minimizes uncertainty in a set of investigator‐defined quantities of interest (QoIs), such as oceanic transports or other key climate indices. We show that Hessian UQ unifies three design concepts. (1) An observing system reduces uncertainty in a target QoI most effectively when it is sensitive to the same dynamical controls as the QoI. The dynamical controls are exposed by the Hessian eigenvector patterns of the model‐data misfit function. (2) Orthogonality of the Hessian eigenvectors rigorously accounts for redundancy between distinct members of the observing system. (3) The Hessian eigenvalues determine the overall effectiveness of the observing system, and are controlled by the sensitivity‐to‐noise ratio of the observational assets (analogous to the statistical signal‐to‐noise ratio). We illustrate Hessian UQ and its three underlying concepts in a North Atlantic case study. Sea surface temperature observations inform mainly local air‐sea fluxes. In contrast, subsurface temperature observations reduce uncertainty over basin‐wide scales, and can therefore inform transport QoIs at great distances. This research provides insight into the design of effective observing systems that maximally inform the target QoIs, while being complementary to the existing observational database.
History of Space Weather Research and Operation in Japan and New Emphasis in Southeast Asia
Authors: Ishii M. , Takizawa O. , Marubashi K. , Den M. 
Published: February 2021

AbstractJapanese space weather research and operation began in 1896 with research on radio propagation. LF, MF, and HF radio communication used to be important before the era of communication satellites; however, they are affected by ionospheric conditions and solar activity. A center for the research and development of radio systems was established at Hiraiso, which is now also a space weather observatory for measuring solar activity, geomagnetic fields, and ionospheric conditions. The need for space weather information initially decreased in the communication satellite age, but since the beginning of the 21st century it has been increasing again with the growing use of positioning satellite systems. The role of Southeast Asian countries in space weather research has become important and the range of activities is also growing. The contribution of these countries to space weather research and operation is expected to grow in future.
Practical prediction model of the clinical response to programmed death-ligand 1 inhibitors in advanced gastric cancer
Authors: Noh Myung-Giun , Yoon Youngmin , Kim Gihyeon , Kim Hyun , Lee Eulgi , Kim Yeongmin , Park Changho , Lee Kyung-Hwa , Park Hansoo 
Published: February 2021

AbstractThe identification of predictive biomarkers or models is necessary for the selection of patients who might benefit the most from immunotherapy. Seven histological features (signet ring cell [SRC], fibrous stroma, myxoid stroma, tumor-infiltrating lymphocytes [TILs], necrosis, tertiary lymphoid follicles, and ulceration) detected in surgically resected tissues (N = 44) were used to train a model. The presence of SRC became an optimal decision parameter for pathology alone (AUC = 0.78). Analysis of differentially expressed genes (DEGs) for the prediction of genomic markers showed that C-X-C motif chemokine ligand 11 (CXCL11) was high in responders (P < 0.001). Immunohistochemistry (IHC) was performed to verify its potential as a biomarker. IHC revealed that the expression of CXCL11 was associated with responsiveness (P = 0.003). The response prediction model was trained by integrating the results of the analysis of pathological factors and RNA sequencing (RNA-seq). When trained with the C5.0 decision tree model, the categorical level of the expression of CXCL11, a single variable, was shown to be the best model (AUC = 0.812). The AUC of the model trained with the random forest was 0.944. Survival analysis revealed that the C5.0-trained model (log-rank P = 0.01 for progression-free survival [PFS]; log-rank P = 0.012 for overall survival [OS]) and the random forest-trained model (log-rank P < 0.001 for PFS; log-rank P = 0.001 for OS) predicted prognosis more accurately than the PD-L1 test (log-rank P = 0.031 for PFS; log-rank P = 0.107 for OS).
Approaching barrier-free contacts to monolayer MoS2 employing [Co/Pt] multilayer electrodes
Authors: Gupta S. , Rortais F. , Ohshima R. , Ando Y. , Endo T. , Miyata Y. , Shiraishi M. 
Published: February 2021

AbstractThe broken inversion symmetry and time-reversal symmetry along with the large spin–orbit interactions in monolayer MoS2 make it an ideal candidate for novel valleytronic applications. However, the realization of efficient spin-valley-controlled devices demands the integration of perpendicular magnetic anisotropy (PMA) electrodes with negligible Schottky barriers. Here, as the first demonstration, we fabricated a monolayer MoS2 field-effect transistor with PMA electrodes: Pt/[Co/Pt]3 and [Co/Pt]2. The I–V curves of PMA/MoS2 contacts show symmetric and linear behavior reflecting Ohmic nature. The flat-band Schottky barrier heights (SBHs) extracted using the temperature and gate voltage dependence of the I–V curves were found to be 10.2 and 9.6 meV. The observed SBHs are record low values reported thus far for any metal/monolayer MoS2 contact. High-quality PMA electrodes with almost zero SBH play a paramount role in the future development of novel spintronic/valleytronic devices; hence, our results can open a new route toward the realization of novel technological devices employing two-dimensional materials.
Direct insight into the structure-property relation of interfaces from constrained crystal structure prediction
Authors: Sun Lin , Marques Miguel A. L. , Botti Silvana 
Published: February 2021

AbstractA major issue that prevents a full understanding of heterogeneous materials is the lack of systematic first-principles methods to consistently predict energetics and electronic properties of reconstructed interfaces. In this work we address this problem with an efficient and accurate computational scheme. We extend the minima-hopping method implementing constraints crafted for two-dimensional atomic relaxation and enabling variations of the atomic density close to the interface. A combination of density-functional and accurate density-functional tight-binding calculations supply energy and forces to structure prediction. We demonstrate the power of this method by applying it to extract structure-property relations for a large and varied family of symmetric and asymmetric tilt boundaries in polycrystalline silicon. We find a rich polymorphism in the interface reconstructions, with recurring bonding patterns that we classify in increasing energetic order. Finally, a clear relation between bonding patterns and electrically active grain boundary states is unveiled and discussed.
Two mechanisms drive pronuclear migration in mouse zygotes
Authors: Scheffler Kathleen , Uraji Julia , Jentoft Ida , Cavazza Tommaso , Mönnich Eike , Mogessie Binyam , Schuh Melina 
Published: February 2021

AbstractA new life begins with the unification of the maternal and paternal chromosomes upon fertilization. The parental chromosomes first become enclosed in two separate pronuclei near the surface of the fertilized egg. The mechanisms that then move the pronuclei inwards for their unification are only poorly understood in mammals. Here, we report two mechanisms that act in concert to unite the parental genomes in fertilized mouse eggs. The male pronucleus assembles within the fertilization cone and is rapidly moved inwards by the flattening cone. Rab11a recruits the actin nucleation factors Spire and Formin-2 into the fertilization cone, where they locally nucleate actin and further accelerate the pronucleus inwards. In parallel, a dynamic network of microtubules assembles that slowly moves the male and female pronuclei towards the cell centre in a dynein-dependent manner. Both mechanisms are partially redundant and act in concert to unite the parental pronuclei in the zygote’s centre.