bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEMEROLEHAN BAHASA INDONESIA ANAK USIA DINI PAUD SAREPAWE KELURAHAN ONEKORE ENDE
Authors: Jamaludin Zaenab , Sherlin Maria Floriani , Ria Maria Polencis 
Published: November 2021

Abstrak: Penelitian ini adalah untuk mengetahui dan mendeskripsikan situasi pemerolehan dan penggunaan bahasa Indonesia anak usia 2-3 tahun di PAUD Sare Pawe yang terletak di Kelurahan Onekore. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan Kualitatif dengan dasar pertimbangan proses pengumpulan data dilakukan dengan metode observasi. Selain dari itu proses analisis data tidak digunakan dengan cara analisis statistik atau penggunaan angka, tabel dan gambar. Teori yang digunakan dalam penelitian ini adalah teori pemerolehan bahasa dan teori Psikolinguistik. Hasil penelitian menunjukan adanya perubahan dalam ujaran-ujaran yang dituturkan oleh anak-anak pada PAUD Sarepawe yakni telah mampu menuturkan lebih dari satu kata. Jadi berdasarkan uraian yang telah dipaparkan terdahulu dapat ditarik kesimpulannya bahwa anak-anak usia dini 3-4 tahu pada PAUD Sarepawe, Kelurahan Onekore telah mampu menuturkan lebih dari satu kata dalam proses komunikasi di antara teman sebaya dan guru di lingkungan sekolah tersebut. Kata Kunci: PAUD; Pemerolehan Bahasa
Hubungan Pengetahuan dan Sikap dengan Penggunaan Alat Pelindung Diri (APD) pada Pekerja Bongkar Muat di Pelabuhan Pantoloan
Authors: Sapriana Sapriana 
Published: November 2021

Semakin rendah frekuensi penggunaan Alat Pelindung Diri (APD) maka semakin besar kesempatan terjadinya kecelakaan kerja. Pengetahuan dan sikap pekerja sangat berpengaruh terhadap penggunaan APD. Penelitian ini bertujuan untuk menganalisis hubungan pengetahuan dan sikap dengan penggunaan APD pada pekerja bongkar muat di Pelabuhan Pantoloan. Penelitian ini merupakan penelitian analitik dengan pendekatan cross sectional, populasi 110 pekerja, sampel 52 pekerja, menggunakan metode accidental sampling. Hasil analisis univariat menunjukkan 61,5% pekerja memiliki pengetahuan baik tentang penggunaan APD, 76,9% pekerja bersikap positif tentang penggunaan APD, dan sebagian besar pekerja tidak menggunakan APD saat bekerja (88,5%). Hasil uji Fisher Exact menunjukkan pengetahuan responden yang baik tentang alat pelindung diri berhubungan dengan perilaku penggunaan APD saat bekerja (p=0,045), dan sikap responden yang positif tentang alat pelindung diri tidak berhubungan dengan perilaku penggunaan APD saat bekerja (p=0,189). Kesimpulan: a) Pengetahuan yang baik tentang alat pelindung diri berhubungan dengan perilaku penggunaan APD saat bekerja; b) Sikap positif tentang alat pelindung diri tidak berhubungan dengan perilaku penggunaan APD saat bekerja. Disarankan melakukan penelitian kualitatif untuk membantu memahami sikap dan pemikiran pekerja tentang penggunaan APD, selain itu kepada pihak terkait, agar berupaya maksimal meningkatkan kesadaran pekerja tentang Kesehatan dan Keselamatan Kerja (K3) khususnya penggunaan APD.
Left-Ventricular Reference Myocardial Strain Assessed by Cardiovascular Magnetic Resonance Feature Tracking and fSENC—Impact of Temporal Resolution and Cardiac Muscle Mass
Authors: Weise Valdés Elena , Barth Peter , Piran Misagh , Laser Kai Thorsten , Burchert Wolfgang , Körperich Hermann 
Published: November 2021

Aims: Cardiac strain parameters are increasingly measured to overcome shortcomings of ejection fraction. For broad clinical use, this study provides reference values for the two strain assessment methods feature tracking (FT) and fast strain-encoded (fSENC) cardiovascular magnetic resonance (CMR) imaging, including the child/adolescent group and systematically evaluates the influence of temporal resolution and muscle mass on strain.Methods and Results: Global longitudinal (GLS), circumferential (GCS), and radial (GRS) strain values in 181 participants (54% women, 11–70 years) without cardiac illness were assessed with FT (CVI42® software). GLS and GCS were also analyzed using fSENC (MyoStrain® software) in a subgroup of 84 participants (60% women). Fourteen patients suffering hypertrophic cardiomyopathy (HCM) were examined with both techniques. CMR examinations were done on a 3.0T MR-system.FT-GLS, FT-GCS, and FT-GRS were −16.9 ± 1.8%, −19.2 ± 2.1% and 34.2 ± 6.1%. fSENC-GLS was higher at −20.3 ± 1.8% (p &lt; 0.001). fSENC-GCS was comparable at−19.7 ± 1.8% (p = 0.06). All values were lower in men (p &lt; 0.001). Cardiac muscle mass correlated (p &lt; 0.001) with FT-GLS (r = 0.433), FT-GCS (r = 0.483) as well as FT-GRS (r = −0.464) and acts as partial mediator for sex differences. FT-GCS, FT-GRS and fSENC-GLS correlated weakly with age. FT strain values were significantly lower at lower cine temporal resolutions, represented by heart rates (r = −0.301, −0.379, 0.385) and 28 or 45 cardiac phases per cardiac cycle (0.3–1.9% differences). All values were lower in HCM patients than in matched controls (p &lt; 0.01). Cut-off values were −15.0% (FT-GLS), −19.3% (FT-GCS), 32.7% (FT-GRS), −17.2% (fSENC-GLS), and −17.7% (fSENC-GCS).Conclusion: The analysis of reference values highlights the influence of gender, temporal resolution, cardiac muscle mass and age on myocardial strain values.
Myokines in Acromegaly: An Altered Irisin Profile
Authors: Mizera Łukasz , Halupczok-Żyła Jowita , Kolačkov Katarzyna , Zembska Agnieszka , Grzegrzółka Jędrzej , Jędrzejuk Diana , Bolanowski Marek , Daroszewski Jacek 
Published: November 2021

IntroductionThe muscle is an endocrine organ controlling metabolic homeostasis. Irisin and myostatin are key myokines mediating this process. Acromegaly is a chronic disease with a wide spectrum of complications, including metabolic disturbances.PurposeTo examine the influence of acromegaly on irisin and myostatin secretion and their contribution to metabolic profile and body composition.Materials and MethodsIn 43 patients with acromegaly and 60 controls, serum levels of irisin, myostatin, growth hormone (GH), insulin-like growth factor 1 (IGF-1), parameters of glucose, and lipid metabolism were determined. Body composition was assessed with dual-energy x-ray absorptiometry.ResultsThe irisin concentration was significantly lower in patients with acromegaly compared to controls (3.91 vs. 5.09 μg/ml, p = 0.006). There were no correlations between irisin and GH/IGF-1 levels. In the study group, irisin was negatively correlated with fasting insulin (r = −0.367; p = 0.042), HOMA-IR (r = −0.510; p = 0.011), and atherogenic factors: Castelli I (r = −0.416; p = 0.005), Castelli II (r = −0.400; p = 0.001), and atherogenic coefficient (AC) (r = −0.417; p = 0.05). Irisin and myostatin concentrations were also lower in acromegalics with insulin resistance than without (2.80 vs. 4.18 μg/ml, p = 0.047; 81.46 vs. 429.58 ng/L, p = 0.018, respectively). There were no differences between study group and controls in myostatin concentration. Myostatin levels negatively correlated with GH (r = −0.306; p = 0.049), HOMA-IR (r = −0.046; p = 0.411), and insulin levels (r = −0.429; p = 0.016).ConclusionsDecreased irisin concentrations in acromegaly may suggest impaired hormonal muscle function contributing to metabolic complications in this disorder. However, learning more about the association between myostatin and GH in acromegaly requires further studies. Nevertheless, it appears that myostatin is not critical for muscle mass regulation in acromegaly.
U-Shaped Association Between Serum Uric Acid and Short-Term Mortality in Patients With Infective Endocarditis
Authors: Wei Xuebiao , Fu Bingqi , Chen Xiaolan , Chen WeiTao , Wang Zhenqian , Yu Danqing , Jiang Guozhi , Chen Jiyan 
Published: November 2021

BackgroundIncreased uric acid (UA) levels have been reported to be associated with poor clinical outcomes in several conditions. However, the prognostic value of UA in patients with infective endocarditis (IE) is yet unknown.MethodsA total of 1,117 patients with IE were included and divided into two groups according to the current definition of hyperuricemia (UA&gt;420 μmol/L in men and &gt;360 μmol/L in women): hyperuricemia group (n=336) and normouricemia group (n=781). The association between the UA level and short-term outcomes were examined.ResultsThe in-hospital mortality was 6.2% (69/1117). Patients with hyperuricemia carried a higher risk of in-hospital death (9.8% vs. 4.6%, p=0.001). Hyperuricemia was not an independent risk factor for in-hospital death (adjusted odds ratio [aOR]=1.92, 95% confidence interval [CI]: 0.92-4.02, p=0.084). A U-shaped relationship was found between the UA level and in-hospital death (p&lt;0.001). The in-hospital mortality was lower in patients with UA in the range 250–400 μmol/L. The aOR of in-hospital death in patients with UA&gt;400 and &lt;250 μmol/L was 3.48 (95% CI: 1.38-8.80, p=0.008) and 3.28 (95%CI: 1.27-8.51, p=0.015), respectively. Furthermore, UA&gt;400 μmol/L (adjusted hazard ratio [aHR]=3.54, 95%CI: 1.77-7.07, p&lt;0.001) and &lt;250 μmol/L (aHR=2.23, 95%CI: 1.03-4.80, p=0.041) were independent risk factors for the 6-month mortality.ConclusionThe previous definition of hyperuricemia was not suitable for risk assessment in patients with IE because of the U-shaped relationship between UA levels and in-hospital death. Low and high levels of UA were predictive of increased short-term mortality in IE patients.
Impact of Different Modules of 21-Gene Assay in Early Breast Cancer Patients
Authors: Chen Mengdi , Liu Deyue , Chen Weilin , Chen Weiguo , Shen Kunwei , Wu Jiayi , Zhu Li 
Published: November 2021

BackgroundThe 21-gene assay recurrence score (RS) provides additional information on recurrence risk of breast cancer patients and prediction of chemotherapy benefit. Previous studies that examined the contribution of the individual genes and gene modules of RS were conducted mostly in postmenopausal patients. We aimed to evaluate the gene modules of RS in patients of different ages.MethodsA total of 1,078 estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer patients diagnosed between January 2009 and March 2017 from Shanghai Jiao Tong University Breast Cancer Data Base were included. All patients were divided into three subgroups: Group A, ≤40 years and premenopausal (n = 97); Group B, &gt;40 years and premenopausal (n = 284); Group C, postmenopausal (n = 697). The estrogen, proliferation, invasion, and HER2 module scores from RS were used to characterize the respective molecular features. Spearman correlation and analysis of the variance tests were conducted for RS and its constituent modules.ResultsIn patients &gt;40 years, RS had a strong negative correlation with its estrogen module (ρ = −0.76 and −0.79 in Groups B and C) and a weak positive correlation with its invasion module (ρ = 0.29 and 0.25 in Groups B and C). The proliferation module mostly contributed to the variance in young patients (37.3%) while the ER module contributed most in old patients (54.1% and 53.4% in Groups B and C). In the genetic high-risk (RS &gt;25) group, the proliferation module was the leading driver in all patients (ρ = 0.38, 0.53, and 0.52 in Groups A, B, and C) while the estrogen module had a weaker correlation with RS. The impact of ER module on RS was stronger in clinical low-risk patients while the effect of the proliferation module was stronger in clinical high-risk patients. The association between the RS and estrogen module was weaker among younger patients, especially in genetic low-risk patients.ConclusionsRS was primarily driven by the estrogen module regardless of age, but the proliferation module had a stronger impact on RS in younger patients. The impact of modules varied in patients with different genetic and clinical risks.
Comprehensive Multi-Omics Identification of Interferon-γ Response Characteristics Reveals That RBCK1 Regulates the Immunosuppressive Microenvironment of Renal Cell Carcinoma
Authors: Xu Wenhao , Tao Juli , Zhu Wenkai , Liu Wangrui , Anwaier Aihetaimujiang , Tian Xi , Su Jiaqi , Shi Guohai , Huang Haineng , Wei Gaomeng , Li Chuanyu , Qu Yuanyuan , Zhang Hailiang , Ye Dingwei 
Published: November 2021

Interferon-gamma (IFN-γ) has a complex role in modulating the tumor microenvironment (TME) during renal cell carcinoma (RCC) development. To define the role of IFN-γ response genes in RCC progression, we characterized the differential gene expression, prognostic implications, and DNA variation profiles of selected IFN-γ response signatures, which exhibited a significant hazard ratio for the overall survival (OS) and progression-free survival (PFS) of papillary, chromophobia, and clear cell RCC (ccRCC) patients (n = 944). Prognostic nomograms were constructed to predict the outcomes for ccRCC patients, highlighting the prognostic implications of RANBP2-type and C3HC4-type zinc finger containing 1 (RBCK1). Interestingly, large-scale pan-cancer samples (n = 12,521) and three single-cell RNA datasets revealed that RBCK1 showed markedly differential expression between cancer and normal tissues and significantly correlated with tumor-infiltrating immune cells, tumor purity, and immune checkpoint molecules, such as PD-L1, CTLA-4, LAG-3, and TIGIT in pan-cancer samples. Notably, the TIDE score was significantly higher in the RBCK1high group compared with the RBCK1low group in both ccRCC and RCC cohorts. Besides, immunohistochemistry staining showed significantly elevated RBCK1 expression in tumors (n = 50) compared with kidney samples (n = 40) from a real-world cohort, Fudan University Shanghai Cancer Center (FUSCC, Shanghai). After RBCK1 expression was confirmed in ccRCC, we found a significantly decreased number of infiltrating CD4+ T cells, CD4+ FOXP3+ Treg cells, M1 macrophages, and CD56bight/dim NK cells in the immune-cold RBCK1high group. In addition to the distinct heterogeneous immune microenvironment, the increased expression of RBCK1 predicted a prominently worse prognosis than the RBCK1low group for 232 ccRCC patients in the FUSCC proteomic cohort. Furthermore, after transfected with siRNA in human ccRCC cells, extraordinarily decreased cell proliferation, migration capacities, and prominently elevated apoptosis tumor cell proportion were found in the siRNA groups compared with the negative control group. In conclusion, this study identified IFN-γ response clusters, which might be used to improve the prognostic accuracy of immune contexture in the ccRCC microenvironment. Immune-cold RBCK1high patients have pro-tumorigenic immune infiltration and significantly worse outcomes than RBCK1low patients based on results from multi-omics to real-world data. Our discovery of novel independent prognostic indicators for RCC highlights the association between tumor alterations and immune phenotype.
Synthesis and Photocatalytic Degradation of Water to Produce Hydrogen from Novel Cerium Dioxide and Silver-Doped Cerium Dioxide Fiber Membranes by the Electrospinning Method
Authors: Pu Xingyu , Wang Chencheng , Chen Xingwang , Jin Jing , Li Wanfei , Chen Feng 
Published: November 2021

The sol-gel method combined with the electrospinning technique were used to synthesize CeO2 nanofiber membranes and CeO2 fiber membranes doped with different contents of nano-silver. The thermal degradation behavior, phase structure, morphology, and optical and photocatalytic hydrogen production efficiency of CeO2 nanofiber membranes and CeO2 fiber membranes doped with different contents of nano-silver were studied. X-ray diffraction (XRD) results indicate that the increase of silver concentration can inhibit the formation of CeO2 crystal. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) observations show that in the prepared CeO2 with a diameter of about 100 nm and fiber membrane material doped with nano-silver, the fiber is made of a large number of accumulating grains. Analysis of optical properties found that the doped nano–silver CeO2 fiber membranes enhance the absorption of visible light and reduce the band gap of the material. Photocatalytic experiments show that the cerium dioxide nanofibers doped with nano-silver can greatly improve the photocatalytic performance of materials than that of pure CeO2. The Ag/CeO2 fiber membrane with the Ag/CeO2 molar ratio of 3:50 possesses the highest photocatalytic hydrogen production efficiency because of its high electron hole transfer and separation efficiency. This novel synthesis strategy can be used to prepare other broad band gap semiconductor oxides and enhance their photocatalytic activity.
The Effect of Virtual Reality-Based Therapy on Improving Upper Limb Functions in Individuals With Stroke: A Randomized Control Trial
Authors: El-Kafy Ehab Mohamed Abd , Alshehri Mansour Abdullah , El-Fiky Amir Abdel-Raouf , Guermazi Mohamad Abdelhamid 
Published: November 2021

Background: Stroke is a common cause of motor disability. The recovery of upper limb after stroke is poor, with few stroke survivors regaining some functional use of the affected upper limb. This is further complicated by the fact that the prolonged rehabilitation is accompanied by multiple challenges in using and identifying meaningful and motivated treatment tasks that may be adapted and graded to facilitate the rehabilitation program. Virtual reality-based therapy is one of the most innovative approaches in rehabilitation technology and virtual reality systems can provide enhanced feedback to promote motor learning in individuals with neurological or musculoskeletal diseases.Purpose: This study investigated the effect of virtual reality-based therapy on improving upper limb functions in individuals with chronic stroke.Methods: Forty Saudi individuals with chronic stroke (6–24 months following stroke incidence) and degree of spasticity ranged between 1, 1 + and 2 according to Modified Ashworth Scale were included in this study. Participants were randomly assigned into two groups, experimental and control, with the experimental group undertaking a conventional 1-h functional training program, followed by another hour of virtual reality-based therapy using Armeo Spring equipment and the control group received 2 h of a conventional functional training program. The treatment program was conducted three times per week for three successive months. The change in the scores of Action Research Arm Test (ARAT), Wolf Motor Function Test (WMFT), WMFT-Time (time required to complete the test) and Hand Grip Strength (HGS) were recorded at baseline and after completion of the treatment. Parametric (paired and unpaired t-tests) non-parametric (Wilcoxon and Mann–Whitney tests) statistical tests were used to identify the differences within and between groups (experimental group and control group) and evaluation times (pre- and immediately post-treatment).Results: Both groups showed significant differences (all, P &lt; 0.05) in all measured variables after 3 months of the treatment. Individuals with stoke in the experimental group had a better improvement in ARAT (P &lt; 0.01), WMFT (P &lt; 0.01) and WMFT-Time (P &lt; 0.01) scores after completion of the treatment compared to the control group. No significant difference in HGS scores was detected between groups after completion of the treatment (P = 0.252).Conclusion: The use of combined treatment of virtual reality-based therapy and conventional functional training program is more effective for improving upper limb functions in individuals with chronic stroke than the use of the conventional program alone.
Therapeutic Hypothermia Modulates the Relationships Between Indicators of Severity of Neonatal Hypoxic Ischemic Encephalopathy and Serum Biomarkers
Authors: Chavez-Valdez Raul , Miller Sarah , Spahic Harisa , Vaidya Dhananjay , Parkinson Charlamaine , Dietrick Barbara , Brooks Sandra , Gerner Gwendolyn J. , Tekes Aylin , Graham Ernest M. , Northington Frances J. , Everett Allen D. 
Published: November 2021

Objective: To determine the changes due to therapeutic hypothermia (TH) exposure in the strength of association between traditional clinical and biochemical indicators of severity of neonatal hypoxic-ischemic encephalopathy (HIE) and serum biomarkers. We hypothesized that culmination of TH changes the strength of the relationships between traditional indicators of severity of HIE and serum biomarkers.Methods: This was a single-center observational cohort study of 178 neonates with HIE treated with TH and followed with serum biomarkers: (i) brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) (neurotrophins); (ii) tau and glial fibrillary acidic protein (GFAP) (neural cell injury); and (iii) interleukin 6 (IL-6), IL-8, and IL-10 (cytokines), during their first week of life. Adjusted mixed-effect models tested associations with HIE indicators in relation to TH exposure.Results: At admission, lower Apgar scores and base excess (BE) and higher lactate and nucleated red blood cell (NRBC) count correlated with higher Sarnat scores. These indicators of worse HIE severity, including higher Sarnat score, correlated with lower VEGF and higher tau, GFAP, and IL-10 levels at different time points. Within the first 24 h of life, patients with a Sarnat score &gt;2 had lower VEGF levels, whereas only those with score of 3 also had higher GFAP and IL-10 levels. Tau levels increased during TH in patients with Sarnat score of 3, whereas tau and GFAP increased after TH in those with scores of 2. After adjustments, lower VEGF levels during TH and higher tau, GFAP, and IL-10 levels during and after TH were associated with worse Sarnat scores. Tau and GFAP relationship with Sarnat score became stronger after TH.Conclusion: Therapeutic hypothermia exerts an independent modulatory effect in the relationships between traditional indicators of severity of HIE and serum biomarkers after adjustments. Thus, the timing of biomarker testing in relation to TH exposure must be carefully considered if biomarkers are proposed for patient stratification in novel clinical trials.