bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicoepidemiological profile and practices to manage dizziness in primary care setting: results from an Indian registry
Authors: Prabhat Divya , Kiran Ganga 
Published: January 2021

<p class="abstract"><strong>Background:</strong> Dizziness is a common symptom encountered in primary care settings by general physicians and specialists. This study evaluated the clinicoepidemiological profile and management practices in patients with dizziness in an Indian primary care setting.</p><p class="abstract"><strong>Methods:</strong> This prospective, multicentric, observational study was conducted between November 2018 and June 2019. Patients aged≥18 years presenting with clinical features of dizziness were eligible. The study data included demographics and socioeconomic details, complete medical history, medication and concomitant medication use, and the cause and pattern of dizziness. Patients had a baseline visit and two follow-up visits at weeks 1 and 4. </p><p class="abstract"><strong>Results:</strong> Overall, 1000 patients with a mean age of 45.1 years were included (women: 51.5%; men: 48.5%). Of these, 762 reported dizziness as a primary complaint; whereas, 238 reported it as a complaint associated with nausea, vomiting and light-headedness on visit 1, which reduced on subsequent visits. Around 34% of the patients were unemployed and 59% belonged to the upper-middle class. The most common co-morbidities were hypertension and diabetes mellitus (n=132, each). More than 50% of the patients presented with vestibular cause (n=577), followed by neurologic (n=179), metabolic (n=84) and psychiatric (n=61) etiologies. Betahistine (n=581) and prochlorperazine (n=312) were the commonly prescribed medicines for primary and associated complaints. The most commonly used concomitant medications were telmisartan (n=53), glimepiride plus metformin (n=40), metformin (n=32) and ondansetron (n=29). </p><p class="abstract"><strong>Conclusions:</strong> Dizziness has a multifactorial origin necessitating a multifactorial treatment approach. Betahistine and prochlorperazine were the most commonly prescribed drugs in the primary care setting (CTRI/2018/11/016408). </p>
Supraglottic laryngeal lymphomatoid granulomatosis in an immunocompetent patient: a case report
Authors: Harvey-Bolduc Simon-Pierre , Guay Benoit 
Published: January 2021

<p>Lymphomatoïd granulomatosis is a rare lymphoproliferative disease caused by Epstein-Barr virus described in 1972 by Liebow. The most common primary localization is the lungs. Other systems are affected occasionally such as the skin, central nervous system, renal and gastrointestinal system. Some cases have been described at the laryngeal level in immunosuppressed patients. This is a case report of supraglottic lymphomatoid granulomatosis in an immunocompetent patient. A literature review on lymphomatoid granulomatosis will be detailed and the clinical case will be described including investigations, treatment and follow-up. The differential diagnosis of this pathology as well as the importance of histopathology will also be discussed. Several radiological imaging and histopathology slides will be presented. Emphasis will be placed on the difficulty of diagnosis given the frequent multisystem involvement and on the importance of the multidisciplinary team approach including otolaryngology, haematology-oncology, nephrology, pathology and radiology. We will end with a discussion about the case with reference to the current literature on the subject.</p>
Type and level of anxiety affects the perception of pain during bone marrow biopsy
Authors: ÖNEÇ Birgül , ONEC Kursad , EŞBAH Ali Ümit , EŞBAH Onur 
Published: January 2021

Objective: Bone marrow aspiration and biopsy (BMAB) is an essential tool for the diagnosis of hematological disorders. The most frequent complaint after BMAB is pain but the severity of this pain is described very different among patients. We investigated factors predicting this pain focusing on the role of state and trait anxiety.

Methods: One hundred and ten adult patients undergoing BMAB, were informed adequately and assessed with “The State-Trait Anxiety Inventory” (STAI) before the procedure. In this Likert-type inventory, State Anxiety Scale evaluates the current state of anxiety, asking how respondents feel “at that moment”. The Trait Anxiety Scale evaluates relatively stable aspects of “anxiety proneness,” including general states of confidence, calmness, and security. After the biopsy, the pain was measured with visual analog scale.

Results: Most of the patients (71.8%) described mild pain but moderate to severe pain were significantly more frequent in both high state and trait anxiety groups. Pain severity had a positive but weak correlation with trait anxiety but not with state anxiety. The described pain level was associated with older age but was not with an indication of biopsy, performance status, comorbidities or previous BMAB experiences.

Conclusion: Results of our study made us thought that a good communication with the
patient and talking about possible outcomes days before procedure might play a role in reducing
his or her anxiety but because age and trait anxiety cannot be changed by using fast-acting
anxiolytic drugs, the advantage of premedication with anxiolytics in order of reducing pain,
would be limited.
Molecular Detection of Antimicrobial Resistance Genes and Virulence Genes in E. coli Isolated from Sheep and Goat Faecal Samples
Authors: Kumar Keshav , Sharma N.S. , Kaur Paviter , Arora A.K. 
Published: January 2021

Background: E. coli is a Gram negative bacterium commonly found in the intestine of animals and humans. Most E. coli are harmless but some can cause infection. Antimicrobial resistance is a public health problem, hence this study was carried out to estimate the antimicrobial resistance pattern and virulotyping of E. coli isolates. Methods: During the period 2018-19, a total of 100 faecal samples from goats (n=50) and sheep (n=50) were processed for isolation and identification of E.coli. All the E. coli isolates were tested for resistance against 10 different antibiotics. The prevalence of various antibiotic resistance genes viz bla TEM, tetA and tetB and virulence genes Stx1, Stx2 and hlyA in all E. coli isolates was determined by PCR. Result: Out of 100 samples, 40 isolates of E.coli (24 from goats and 16 from sheep) were isolated, identified biochemically and by PCR. Majority of the E.coli isolates were found resistant to penicillin (100%) followed by ampicillin (93%), tetracycline, (68.8%), gentamicin (37.4%), ceftriazone (18.8%), amikacin (16.7%), chloramphenicol (4.2%), co- trimoxazole (4.2%) and ofloxacin (4.2%). Out of all the isolates, 12 isolates were positive for blaTEM, 10 for tetB, 19 for tetA, five for Stx1 and hlyA and none carried Stx2 gene.
Identifikasi dan Uji Toksisitas terhadap Larva Udang (Artemia salina L.) Ekstrak Bekatul Menggunakan Variasi Jenis Pelarut dan Lama Ekstraksi
Authors: Jannah Dewi Wardatul , Maunatin Anik , Jannah Akyunul 
Published: January 2021

Rice bran was extracted using ultrasonic method with varied solvents (ethanol, ethyl acetate and n-hexane) and extraction times (20, 25 and 30 minutes). The aim of this study was to determine toxicity value of rice bran extract with variation of solvents and extraction times. Rice bran extracts were tested its toxicity by BSLT method and its secondary metabolite by phytochemical test with reagents. Mortality data of shrimp larvae was analyzed by probit to determine LC50 values. Yield of ethanolic extract of rice bran for E1-20, E1-25 and E1-30 samples was 18.159, 19.132 and 18.280%, respectively. Rice bran extracts by ethyl acetate solvent (E2) and n-hexane (E3) gave different yields such as 8.302% (E2-20), 7.282% (E2-25), 9.18% (E2-30), 7.815% (E3-20), 7.125% (E3-25), and 7.279% (E3-30). All of rice bran extracts contained flavonoids, steroids and triterpenoids. LC50 values in ethanolic extract of rice bran for E1-20, E1-25 dan E1-30 samples were 613.258, 673.210 and 2217.255 ppm, respectively. Toxicity (LC50) values of ethyl acetate extract of rice bran were 1161.298 ppm (E2-20), 1170.774 ppm (E2-25) and 701.532 ppm (E2-30), while toxicity (LC50) values of n-hexane extract of rice bran were 592.901 ppm (E3-20), 617.425 ppm (E3-25) and 695.198 ppm (E3-30). Keywords: Rice bran, secondary metabolite, toxicity, ultrasonic method Bekatul diekstrak menggunakan metode ultrasonik dengan variasi pelarut (etanol, etil asetat dan n-heksana) dan lama ekstraksi (20, 25 dan 30 menit). Tujuan penelitian ini adalah mengetahui nilai toksisitas ekstrak bekatul dengan variasi pelarut dan lama ekstraksi. Ekstrak bekatul diuji kemampuan toksisitas terhadap larva udang dengan metode BSLT dan diuji fitokimia dengan reagen. Data kematian larva udang dianalisis dengan analisis probit untuk menentukan nilai LC50. Rendemen ekstrak etanol bekatul yang diperoleh pada sampel E1-20, E1-25 dan E1-30 masing-masing sebesar 18,159; 19,132; dan 18,280%. Adapun rendemen ekstrak etil asetat dan n-heksana bekatul sebesar 8,302% (E2-20), 7,282% (E2-25), 9,18% (E2-30), 7,815% (E3-20), 7,125% (E3-25) dan 7,279% (E3-30). Senyawa metabolit sekunder yang terkandung pada masing-masing ekstrak adalah flavonoid, steroid dan triterpenoid. Nilai LC50 ekstrak etanol pada masing-masing sampel E1-20, E1-25 dan E1-30 adalah 613,258; 673,210 dan 2217,255 ppm. Ekstrak etil asetat bekatul pada sampel E2-20, E2-25 dan E2-30 memberikan nilai toksisitas dengan LC50 sebesar 1161,398; 1170,774 dan 701,532 ppm, berturut-turut. Nilai toksisitas (LC50) ekstrak n-heksana pada sampel E3-20, E3-25 dan E3-30 adalah 592,901; 617,425 dan 695,198 ppm, berturut-turut. Kata kunci: Bekatul, metabolit sekunder, toksisitas, metode ultrasonik
Pelaksanaan Wajib Notifikasi (WiFi) TB di Dinas Kesehatan Kabupaten Jember
Authors: Wadudah Fiya , Prasetyowati Irma , Bumi Candra 
Published: January 2021

Indonesia mengikuti target eliminasi global yaitu Eliminasi TB 2035 dan Indonesia bebas TB 2050. Tantangan dalam program pengendalian Tuberkulosis di Indonesia adalah banyaknya kasus tuberkulosis yang tidak terdeteksi maupun kasus yang sudah terdeteksi namun belum terlaporkan, sehingga perlu dilakukan perubahan pendekatan penemuan kasus, dari secara pasif menjadi intensif dan aktif. Rumitnya pengisian form TB oleh dokter swasta, membuat rendahnya notifikasi pasien TB. Maka dibuat aplikasi berbasis smartphone yaitu Aplikasi Wajib Notifikasi TB (WiFi) TB yang lebih sederhana dan mudah digunakan. Penelitian ini bertujuan untuk menggambarkan pelaksanaan wajib noifikasi (WiFi) TB di Dinas Kesehatan Kabupaten Jember. Penelitian ini menggunakan jenis penelitian deskriptif. Sampel penelitian adalah 2 petugas TB. Penelitian ini dianalisis menggunakan analisis deskriptif. Hasil dari penelitian ini menunjukkan bahwa gambaran dari aspek input, proses, dan output dalam pelaksanaan wajib notifikasi (WiFi) TB
Level of Effectiveness for ERP System in Improving the Educational Process in Higher Education Institutions in Yemen: A Case Study of the University of Science and Technology
Authors: Ali AL-Mandi Mohammed , AL-Sharjabi Abdulrahman 
Published: January 2021

This study aimed to identify the level of effectiveness of the Enterprises Resource Planning (ERP) in improving the educational process in higher education institutions in Yemen. The case study was carried out in the University of Science and Technology (UST). The study adopted the analytical descriptive method, using a questionnaire, which was distributed to the whole population (90 employees), who deal with the ERP system at the university, and who were selected by the complete census method. Only 74 questionnaires were returned and were subject to statistical analysis. Major findings revealed that there was a statistically significant correlation between the dimensions of the questionnaire and the overall effectiveness of the ERP system at the university. Therefore, this result indicates that there is a high degree of effectiveness of the ERP system in improving the educational process with a high agreement score on the dimensions of the questionnaire. It was found that the highest effectiveness degree was in the dimension of admission and registration support, followed by academic support and student affairs, and the lowest degree was in the dimension of technical support. Overall, the level of application of the ERP system at the university was high. Based on these findings, it was recommended that this system should be applied so as to cover all departments that do not use the ERP system, which would lead to effective and efficient performance of such departments.
Keywords: ERP system effectiveness, educational process, higher education institutions
A Single Retrograde Intramedullary Nail Technique for Treatment of Displaced Proximal Humeral Fractures in Children
Authors: Samara Eleftheria , Tschopp Benjamin , Kwiatkowski Barbara , Vardar Elif , Lutz Nicolas , Zambelli Pierre-Yves 
Published: January 2021

Background:
Displaced proximal humeral fractures in older children with low remodeling potential need to be reduced and fixed. There are many options for stabilization, including external fixation, rigid internal fixation with screws and plates, percutaneous pinning, and flexible intramedullary nailing. The use of 2 flexible retrograde nails, originated at the University of Nancy, France, became the most popular technique in Europe. The aim of this study was to describe and assess a modified, single retrograde nail technique to treat fractures of the proximal part of the humerus.

Methods:
We performed a retrospective monocentric study. From June 2016 to May 2019, a modified retrograde nail technique with 1 prebent nail was used for the management of 21 consecutive children with a closed displaced proximal humeral fracture. Demographic and surgical data were collected. The surgical technique is similar to the classic elastic stable intramedullary nailing, but only 1 nail is used. The average surgical time and perioperative complications were used as criteria for the feasibility of this technique. Radiographs were obtained preoperatively; at 1, 4, and 6 weeks postoperatively; and after implant removal at an average of 4.2 months postoperatively. The clinical outcomes were assessed on the basis of the shoulder range of motion documented in the medical records and by using the French edition of the QuickDASH (shortened version of the Disabilities of the Arm, Shoulder and Hand [DASH] questionnaire) evaluation scale at the time of implant removal.

Results:
Nineteen patients with a mean age of 12.6 years and a mean follow-up of 6 months were included in the study. The mean surgical time was 49 minutes. The single intramedullary nail technique provided a satisfactory reduction of all fractures. No perioperative complication occurred. In 1 case, partial loss of reduction was observed on the first-week control radiograph. All patients had a healed fracture, no deficits, excellent results according to the QuickDASH score, a normal range of motion, and excellent strength of the shoulder joint at the time of implant removal (at a mean of 4.2 months).

Conclusions:
The current study confirms the feasibility and efficacy of the single retrograde intramedullary nail technique to treat displaced proximal humeral fractures in children.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Survive, Revive, Thrive: Chapter 4: Opening the Sails
Authors: Blasingame Tom 
Published: January 2021

Only put off until tomorrow what you are willing to die having left undone. - Pablo Picasso, Spanish painter/sculptor, 1881-1973
It’s Time To Look at the Horizon
“Opening our sails” is a metaphor that the worst of the storm has passed or is passing, and it is time to get our-selves shipshape, making necessary repairs and preparations, and get back on course. As individuals, and certainly as SPE, we must be ready to cautiously open our sails. The pandemic may be at or near its peak, and despite relatively strong economic performance in most sec-tors, we know that the global economy remains fragile. As an industry, we don’t have the luxury of waiting. We must provide energy and feedstock in advance of global needs, so it is time to get busy and plan not for what was but for what will be.
The energy map, meaning the needs, resources, economies, and priorities of the world, is changing. The oil and gas industry will continue to adapt, but as I have mentioned many times, the need for the service we provide is greater now than ever before. We need to be prepared for both increasing demand and public apathy for what we do. This is nothing new, and capital investments in oil and gas should begin to increase as we enter the new year. Perhaps not at the rates we saw during the “shale revolution,” but investors know how essential we are to a strong global economy and will act accordingly.
I believe Picasso was right. We must develop the discipline to sacrifice for our passions completely, for what we are doing is too important to wait and too important to sleep. Person-ally, I have a compulsive need to serve and to create. The service part probably came from having older parents who came from, let’s say, very modest circumstances, and the creative part perhaps from the desire to take things apart and put them back together with the fewest possible parts left over. I mention this because each of us has an artist, a writer, an engineer, a doctor, and maybe even a mad scientist inside them. And each of us has our own compulsions. In the post-pandemic, we need to channel that same discipline that Picasso implies. Our passions are our compass, and our energy derives from our compulsion to fulfill those passions.
My challenge to you, as an industry, is to align your passions. Someone recently told me that the pandemic had provided us the opportunity of a generation to realign our priorities. I believe it is the opportunity of a lifetime. We can choose to fear the future, or we can create it. It is that simple.
Geothermal Well Construction: A Step Change in Oil and Gas Technologies
Authors: Feder Judy 
Published: January 2021

Geothermal energy has been described as an engineering problem that, when solved, provides the clean, reliable, safe, and affordable energy being sought globally. It is highly likely that the engineers who play the biggest role in solving that problem, and the technologies they adapt and advance, will come from oil and gas. There is enough energy in the earth’s crust, just a few miles down, to power all of humanity for ages, according to the US Advanced Research Projects Agency-Energy. The problem is how to tap into it safely, efficiently, and cost effectively.
After many years of failure to launch because of technology or cost limitations, new companies and technologies - and smarter ways of leveraging those that already exist - are bringing geothermal out of its doldrums, to the point that it may finally be ready to scale and become a major player in the transition to cleaner energy, according to Jamie Beard, executive director of the Geothermal Entrepreneurship Organization (GEO) at The University of Texas at Austin (UT-Austin). “The cutting-edge technological developments in geothermal are devoted to drilling into ever-deeper, hotter, and harder rock,” she said, “and oil and gas holds the key to cost reduction for all of these concepts.”
Eric Van Oort, drilling and well engineering expert, educator, and scientist, agrees. The UT-Austin engineering professor and director of the rig automation and performance improvement in drilling (RAPID) industry consortium, said, “Fifty to seventy-five percent of the cost of geothermal development is tied up in drilling and well construction. To scale it, we have to reduce that cost.”
Designing for Extremes
Well design for geothermal wells is similar to that for oil and gas wells. The challenges arise from drilling deeper and deeper, into hotter and hotter rock. Heat ranging from 150°C (302°F) to 373°C (703°F) and above can be used to profitably generate electricity. Oil and gas well designs traditionally have not had to contend with these extremes.
Thermal considerations are unavoidable in deep geothermal well construction. Temperature and thermal effects, chemical composition of produced fluids, and rate of production or pressure depletion pose significant challenges to well casing and design.
Nick Cameron, reservoir characterization manager at BP and leader of the supermajor’s studies into geothermal energy, said his company is using corporate data, geological understanding, and oil and gas expertise and experience to look at where their technology can reduce risk and drive down the cost of development. “Metallurgical understanding of materials and how they handle heat is crucial to these efforts,” he said. “Fortunately, there have been significant advancements in this area in recent years.” Cameron said that much work is also being done into changing the chemical composition of the fluids that flow through the geothermal reservoirs.
How Real-Time Evaluation of Slugging Severity Can Help Maximize Production
Authors: Burgos Andreas , Wollebæk Lars 
Published: January 2021

In recent years, Aker BP has explored and developed a number of digital improvements to optimize production. The underlying business drivers are meant to improve efficiency, increase production and reserves, decrease costs, and reduce the carbon footprint from operations.
The example described in this article has innovative elements of digitalization and automation of workflows which provide a new approach for better handling of slugging in subsea developments with long tiebacks. The new solution has a potential for optimizing production and limiting the amount of flaring.
Flow Instabilities in the Vilje Field
The Aker BP-operated Vilje field in the Norwegian Continental Shelf has occasionally experienced production-flow instabilities in the production pipelines and risers due to slugging. The company worked with Turbulent Flux to develop a software solution, the FLUX Stability Adviser, to continuously and precisely monitor production in real time.
Field Description and Outline of Problem
The Vilje field is a subsea development with three horizontal producers tied back to the Alvheim floating production, storage, and offloading (FPSO) facility through a production line longer than 20 km. The inlet separator at Alvheim is shared with other third-party developments. After an initial period of dry-oil production at the field, which started production in 2008, the oil rate has gradually decreased as a result of increased water cuts (WC) over time. Gas lift has been used to sustain production. The occasional slugging at the inlet separator had been controlled by increasing the backpressure to the production line and/or shutting in one of the producers. However, this practice affects production potential and may lead to production losses or deferral.
Explanation of the Solution
The two companies developed a Stability Adviser application to advise operators of the settings to optimize production in real time while lowering the risks related to slugging at any point in time.
The developed solution runs on a cloud infrastructure with an interactive web-user interface. The main user interface contains a 3D heat map which is based on output from a series of pre-run transient simulations and a statistical analysis of the associated slugging severity. The model quality of the pre-run simulations was benchmarked with field data, and a similarity index was introduced to evaluate the degree of matching.
Transient multiphase flow simulations represent the state of the art in the prediction and analysis of slugging behavior in multiphase transport pipelines (both terrain-induced and hydrodynamic slugging). These simulators capture and follow slugs as they are forming along the pipeline. That said, these simulations are time consuming, which limits their usefulness in a real-time operational context.