bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Formal Model for the Simulation and Analysis of Early Biofilm Formation
Authors: Cerone Antonio , Marsili Enrico 
Published: March 2021

AbstractBiofilms are structured communities of bacterial cells adherent to a surface. This bacterial state is called sessile.This paper focuses on the modelling of the transition between planktonic and sessile state using Real-time Maude as the modelling language. With more and more bacteria joining the sessile community, the likelihood of producing a biofilm increases. Once the percentage of bacterial cells that adheres to the surface reaches a threshold, which is specific for the considered bacterium species, a permanent biofilm is formed. An important challenge is to predict the time needed for the formation of a biofilm on a specific surface, in order to plan when the material infrastructure that comprises such a surface needs to be cleaned or replaced. We exploit the model-checking features of Real-time Maude to formally prove that a regular cleaning or replacement of the infrastructure prevents the biofilm formation.
Gauge theory formulation of hyperbolic gravity
Authors: Ferrari Frank 
Published: March 2021

AbstractWe formulate the most general gravitational models with constant negative curvature (“hyperbolic gravity”) on an arbitrary orientable two-dimensional surface of genusgwithbcircle boundaries in terms of a PSL(2,ℝ)∂gauge theory of flat connections. This includes the usual JT gravity with Dirichlet boundary conditions for the dilaton field as a special case. A key ingredient is to realize that the correct gauge group is not the full PSL(2,ℝ), but a subgroup PSL(2,ℝ)∂of gauge transformations that go to U(1) local rotations on the boundary. We find four possible classes of boundary conditions, with associated boundary terms, that can be applied to each boundary component independently. Class I has five inequivalent variants, corresponding to geodesic boundaries of fixed length, cusps, conical defects of fixed angle or large cylinder-shaped asymptotic regions with boundaries of fixed lengths and extrinsic curvatures one or greater than one. Class II precisely reproduces the usual JT gravity. In particular, the crucial extrinsic curvature boundary term of the usual second order formulation is automatically generated by the gauge theory boundary term. Class III is a more exotic possibility for which the integrated extrinsic curvature is fixed on the boundary. Class IV is the Legendre transform of class II; the constraint of fixed length is replaced by a boundary cosmological constant term.
High incidence of superficial and deep medial collateral ligament injuries in ‘isolated’ anterior cruciate ligament ruptures: a long overlooked injury
Authors: Willinger Lukas , Balendra Ganesh , Pai Vishal , Lee Justin , Mitchell Adam , Jones Mary , Williams Andy 
Published: March 2021

Abstract
Purpose
In anterior cruciate ligament (ACL) injuries, concomitant damage to peripheral soft tissues is associated with increased rotatory instability of the knee. The purpose of this study was to investigate the incidence and patterns of medial collateral ligament complex injuries in patients with clinically ‘isolated’ ACL ruptures.

Methods
Patients who underwent ACL reconstruction for complete ‘presumed isolated’ ACL rupture between 2015 and 2019 were retrospectively included in this study. Patient’s characteristics and intraoperative findings were retrieved from clinical and surgical documentation. Preoperative MRIs were evaluated and the grade and location of injuries to the superficial MCL (sMCL), dMCL and the posterior oblique ligament (POL) recorded. All patients were clinically assessed under anaesthesia with standard ligament laxity tests.

Results
Hundred patients with a mean age of 22.3 ± 4.9 years were included. The incidence of concomitant MCL complex injuries was 67%. sMCL injuries occurred in 62%, dMCL in 31% and POL in 11% with various injury patterns. A dMCL injury was significantly associated with MRI grade II sMCL injuries, medial meniscus ‘ramp’ lesions seen at surgery and bone oedema at the medial femoral condyle (MFC) adjacent to the dMCL attachment site (p < 0.01). Logistic regression analysis identified younger age (OR 1.2, p < 0.05), simultaneous sMCL injury (OR 6.75, p < 0.01) and the presence of bone oedema at the MFC adjacent to the dMCL attachment site (OR 5.54, p < 0.01) as predictive factors for a dMCL injury.

Conclusion
The incidence of combined ACL and medial ligament complex injuries is high. Lesions of the dMCL were associated with ramp lesions, MFC bone oedema close to the dMCL attachment, and sMCL injury. Missed AMRI is a risk factor for ACL graft failure from overload and, hence, oedema in the MCL (especially dMCL) demands careful assessment for AMRI, even in the knee lacking excess valgus laxity. This study provides information about specific MCL injury patterns including the dMCL in ACL ruptures and will allow surgeons to initiate individualised treatment.

Level of evidence
III.
Tempered D-modules and Borel–Moore homology vanishing
Authors: Beraldo Dario 
Published: March 2021

AbstractWe characterize the tempered part of the automorphic Langlands category $$\mathfrak {D}({\text {Bun}}_G)$$

D
(

Bun
G

)

using the geometry of the big cell in the affine Grassmannian. We deduce that, for G non-abelian, tempered D-modules have no de Rham cohomology with compact support. The latter fact boils down to a concrete statement, which we prove using the Ran space and some explicit t-structure estimates: for G non-abelian and $$\Sigma $$
Σ
a smooth affine curve, the Borel–Moore homology of the indscheme $${\text {Maps}}(\Sigma ,G)$$

Maps
(
Σ
,
G
)

vanishes.
Spots, stripes, and spiral waves in models for static and motile cells
Authors: Liu Yue , Rens Elisabeth G. , Edelstein-Keshet Leah 
Published: March 2021

AbstractThe polarization and motility of eukaryotic cells depends on assembly and contraction of the actin cytoskeleton and its regulation by proteins called GTPases. The activity of GTPases causes assembly of filamentous actin (by GTPases Cdc42, Rac), resulting in protrusion of the cell edge. Mathematical models for GTPase dynamics address the spontaneous formation of patterns and nonuniform spatial distributions of such proteins in the cell. Here we revisit the wave-pinning model for GTPase-induced cell polarization, together with a number of extensions proposed in the literature. These include introduction of sources and sinks of active and inactive GTPase (by the group of A. Champneys), and negative feedback from F-actin to GTPase activity. We discuss these extensions singly and in combination, in 1D, and 2D static domains. We then show how the patterns that form (spots, waves, and spirals) interact with cell boundaries to create a variety of interesting and dynamic cell shapes and motion.
On the convergence of a Block-Coordinate Incremental Gradient method
Authors: Palagi Laura , Seccia Ruggiero 
Published: March 2021

AbstractIn this paper, we study the convergence of a block-coordinate incremental gradient method. Under some specific assumptions on the objective function, we prove that the block-coordinate incremental gradient method can be seen as a gradient method with errors and convergence can be proved by showing the error at each iteration satisfies some standard conditions. Thus, we can prove convergence towards stationary points when the block incremental gradient method is coupled with a diminishing stepsize and towards an$$\epsilon $$ϵ-approximate solution when a bounded away from zero stepsize is employed.
Phase 1 cohort expansion study of LY3023414, a dual PI3K/mTOR inhibitor, in patients with advanced mesothelioma
Authors: Zauderer Marjorie G. , Alley Evan W. , Bendell Johanna , Capelletto Enrica , Bauer Todd M. , Callies Sophie , Szpurka Anna M. , Kang Suhyun , Willard Melinda D. , Wacheck Volker , Varghese Anna M. 
Published: March 2021

SummaryBACKGROUND LY3023414 is a selective, ATP competitive inhibitor of class I PI3K isoforms, mTORC1/2 and DNA-PK. A Phase 1 dose escalation, 200 mg twice daily (BID) of LY3023414 was the determined recommended phase 2 dose (RP2D). We report the antitumor activity and safety of LY3023414 monotherapy in patients with advanced mesothelioma.METHODS Patients enrolled had advanced malignant pleural or peritoneal mesothelioma with measurable disease, ECOG PS 0–1, were refractory or ineligible to receive standard therapies. Patients received LY3023414 200 mg BID. This dose expansion cohort is intended to evaluate preliminary antitumor activity of LY3023414 by overall response rate. Safety, tolerability and pharmacokinetics were assessed. Biomarkers associated with treatment response was an exploratory endpoint. RESULTS Forty-two patients received LY3023414 for a median duration of 11.2 weeks (range: 1.1–53.0). One patient had a confirmed partial response (PR) (ORR 2.4%). Three patients had an unconfirmed PR. Seventeen patients had stable disease (SD) (DCR 43%). Most common adverse events (AEs) included fatigue (43%), nausea (43%), decreased appetite (38%), vomiting (33%), and diarrhea (29%). AEs were mostly mild or moderate. Grade ≥ 3 AEs were reported for 21% of patients with fatigue as the most frequent event (10%). Alterations of BAP1 were identified in 11/19 patients as the most common molecular aberration, followed by SETD2 and NF2 alterations. No obvious pattern of genetic changes/mutations in single genes or pathways was associated with anti-tumor activity. CONCLUSION LY3023414 monotherapy (200 mg BID) demonstrated an acceptable and manageable safety profile with limited single-agent activity in patients with advanced mesothelioma. ClinicalTrials.gov identifier: NCT01655225; Date of registration: 19 July 2012.
State of the art for treatment of bony defects around anterior shoulder instability—the American perspective
Authors: Kakazu Rafael , LeVasseur Matthew R. , Arciero Robert A. , Mazzocca Augustus D. 
Published: March 2021

AbstractWhile arthroscopic Bankart repair yields high success rates, bone loss on the glenoid or humeral head can portend a poor outcome. The authors recommend a thorough evaluation including computed tomography (CT) scanning to best evaluate the amount of bone loss. Multiple studies have shown that the outcomes of revision stabilization procedures are inferior to the respective primary procedure; thus, it is of paramount importance to select the correct index procedure to optimize patient outcome. The authors present the American perspective on treating shoulder instability. For patients with a small on-track Hill Sachs lesion and less than 10 % glenoid bone loss, an isolated arthroscopic Bankart repair is appropriate. This procedure is also recommended for bony Bankart lesions, as well as in overhead throwing athletes. With an engaging Hill Sachs lesion and less than 15 % glenoid bone loss, the authors recommend the addition of a remplissage to the arthroscopic Bankart repair. For patients with up to 15 % bone loss or following a failed previous arthroscopic repair, the authors advocate for open Bankart repair. They recommend Latarjet in patients with a non-engaging Hill Sachs lesion greater than 15 % bone loss. Patients with bone loss over 30 % would benefit from bone grafting with iliac crest autograft or distal tibia allograft for stabilization. In summary, the authors believe that the index procedure provides an opportunity to optimize patient outcome and careful consideration of the treatment options is warranted.
Self-compassion and repetitive thinking in relation to depressive mood and fear of the future
Authors: Jansen Petra 
Published: March 2021

AbstractThe coronavirus pandemic has had a high impact on mental health. Also, semiprofessional football players are strongly affected by the coronavirus disease 2019 (COVID-19) because training during the lockdown phase has been forbidden. It was the primary goal of this study to investigate if those athletes suffer from a depressive mood and fear of the future. Furthermore, the question was asked whether the psychological variables of self-compassion and repetitive thinking are related to this. A total of 55 semiprofessional football players completed a demographic questionnaire with questions related to depressive mood and fear of the future, and a rumination-, worry- and self-compassion scale. The results show an association between the negative scale of self-compassion and depressive mood as well as fear of the future. Whereas depressive mood was predicted by self-compassion, fear of the future was only indirectly predicted by self-compassion by the mediating effects of repetitive thinking. Also, in semiprofessional football, self-compassion interventions might be a useful tool in difficult times.
Contactless temperature measurement in wire-based electron beam additive manufacturing Ti-6Al-4V
Authors: Pixner F. , Buzolin R. , Schönfelder S. , Theuermann D. , Warchomicka F. , Enzinger N. 
Published: March 2021

AbstractThe complex thermal cycles and temperature distributions observed in additive manufacturing (AM) are of particular interest as these define the microstructure and the associated properties of the part being built. Due to the intrinsic, layer-by-layer material stacking performed, contact methods to measure temperature are not suitable, and contactless methods need to be considered. Contactless infrared irradiation techniques were applied by carrying out thermal imaging and point measurement methods using pyrometers to determine the spatial and temporal temperature distribution in wire-based electron beam AM. Due to the vacuum, additional challenges such as element evaporation must be overcome and additional shielding measures were taken to avoid interference with the contactless techniques. The emissivities were calibrated by thermocouple readings and geometric boundary conditions. Thermal cycles and temperature profiles were recorded during deposition; the temperature gradients are described and the associated temperature transients are derived. In the temperature range of the α+β field, the cooling rates fall within the range of 180 to 350 °C/s, and the microstructural characterisation indicates an associated expected transformation of β→α'+α with corresponding cooling rates. Fine acicular α and α’ formed and local misorientation was observed within α as a result of the temperature gradient and the formation of the α’.
How Does Railway Respond to the Spread of COVID-19? Countermeasure Analysis and Evaluation Around the World
Authors: Yin Yonghao , Li Dewei , Zhang Songliang , Wu Lifu 
Published: March 2021

AbstractThe global COVID-19 pandemic is having a significant impact on the development of many aspects all over the world. As an important part of public services, rail transit requires effective response countermeasures to control the spread of COVID-19. Considering the current development of the epidemic situation, this article discusses the characteristics of COVID-19 transmission and identifies vulnerable areas to target in order to prevent and control the spread of the epidemic in the rail transit system. Countermeasures adopted to prevent the spread of COVID-19 are analyzed in terms of external and internal categories, which were classified into six groups: passenger service, case care, information, staff, equipment and operation management. An evaluation architecture was also constructed, which was established from the perspective of effectiveness, economic efficiency, acceptability, privacy and so on. The effect of implementing the measures was evaluated by a social survey, and their advantages and shortcomings were analyzed, which can be used to guide future epidemic prevention and control for rail transit systems around the world. It is important to formulate a reasonable work schedule according to local conditions, providing a reference for rapid response to future public health emergencies of international concern.
Phenotypic frailty and multimorbidity are independent 18-year mortality risk indicators in older men
Authors: Strandberg Timo E. , Lindström Linda , Jyväkorpi Satu , Urtamo Annele , Pitkälä Kaisu H. , Kivimäki Mika 
Published: March 2021

Abstract
Purpose
Multimorbidity, prefrailty, and frailty are frequent in ageing populations, but their independent relationships to long-term prognosis in home-dwelling older people are not well recognised.

Methods
In the Helsinki Businessmen Study (HBS) men with high socioeconomic status (born 1919–1934, n = 3490) have been followed-up from midlife. In 2000, multimorbidity (≥ 2 conditions), phenotypic prefrailty and frailty were determined in 1365 home-dwelling men with median age of 73 years). Disability was assessed as a possible confounder. 18-year mortality follow-up was established from registers and Cox regression used for analyses.

Results
Of the men, 433 (31.7%) were nonfrail and without multimorbidity at baseline (reference group), 500 (36.6%) and 82 (6.0%) men had prefrailty or frailty, respectively, without multimorbidity, 84 (6.2%) men had multimorbidity only, and 201 (14.7%) and 65 (4.8%) men had prefrailty or frailty together with multimorbidity. Only 30 (2.2%) and 86 (6.3%) showed signs of ADL or mobility disability. In the fully adjusted analyses (including ADL disability, mental and cognitive status) of 18-year mortality, frailty without multimorbidity (hazard ratio 1.62, 95% confidence interval 1.13–2.31) was associated with similar mortality risk than multimorbidity without frailty (1.55, 1.17–2.06). The presence of both frailty and multimorbidity indicated a strong mortality risk (2.93, 2.10–4.07).

Conclusion
Although multimorbidity is generally considered a substantial health problem, our long-term observational study emphasises that phenotypic frailty alone, independently of disability, may be associated with a similar risk, and a combination of multimorbidity and frailty is an especially strong predictor of mortality.
Modeling of magneto-conductivity of bismuth selenide: a topological insulator
Authors: Kumar Yogesh , Sultana Rabia , Sharma Prince , Awana V. P. S. 
Published: March 2021

AbstractWe report the magneto-conductivity analysis of Bi2Se3 single crystal at different temperatures in a magnetic field range of ± 14 T. The single crystals are grown by the self-flux method and characterized through X-ray diffraction, Scanning Electron Microscopy, and Raman Spectroscopy. The single crystals show magnetoresistance (MR%) of around 380% at a magnetic field of 14 T and a temperature of 5 K. The Hikami–Larkin–Nagaoka (HLN) equation has been used to fit the magneto-conductivity (MC) data. However, the HLN fitted curve deviates at higher magnetic fields above 1 T, suggesting that the role of surface-driven conductivity suppresses with an increasing magnetic field. This article proposes a speculative model comprising of surface-driven HLN and added quantum diffusive and bulk carriers-driven classical terms. The model successfully explains the MC of the Bi2Se3 single crystal at various temperatures (5–200 K) and applied magnetic fields (up to 14 T).
The utilization of bentonite enhanced termite mound soil mixture as filter for the treatment of paint industrial effluent
Authors: Opafola Omobolaji Taofeek , David Adekunle Olorunlowo , Ajibade Fidelis Odedishemi , Adeyemi Hezekiah Oluwoye , Solana Olorunfunmi Isimioluwa , Odugbose Babashola Dapo 
Published: March 2021

AbstractThis research investigates the applicability of bentonite enhanced termite mound soil mixture as an alternative filter medium for paint industrial wastewater (PIWW) management in a constructed pilot-scale filtration tank with four different sections. The mixture of bentonite (BC) and termite mound soil (MS) used as the filter was proportioned by percentage weight as (100% MS), $${\text{(5\% BC}} + {\text{95\% MS),}}$$

(5\% BC

+

95\% MS),

$${\text{(10\% BC}} + {\text{90\% MS),}}$$

(10\% BC

+

90\% MS),

$${\text{(15\% BC}} + {\text{85\% MS)}}$$

(15\% BC

+

85\% MS)

and placed into four sections, respectively. The filter materials were compacted, cured and subjected to wastewater loading for 30 weeks. The results obtained from the analysis of the filtrate samples revealed that filter with 15% BC content generally exhibited high and effective pollutant removal efficiencies of 51.3%, 98.9%, and 72.7% for total dissolved solids, total suspended solids, and copper, respectively, while a maximum removal efficiency of 100% was recorded for lead, chromium and cadmium. The pollutants (TDS, TSS, Pb, Cr, Cu and Cd) concentrations of the treated PIWW were below the National Environmental Standards and Regulations Enforcement Agency permissible limits for discharge. Hence, the 15% bentonite and 85% termite mound soil mixtures are recommended for the small-scale paint industries as a point of use measure for effective pollutant removal. Its application would mitigate the degradation of environmental resources caused by indiscriminate disposal of untreated effluent.
Productivity improvement in butt joining of thick stainless steel plates through the usage of activated TIG welding
Authors: Saha Suman , Paul Bashab Chandra , Das Santanu 
Published: March 2021

AbstractActivated tungsten inert gas (A-TIG) welding is one variant of conventional TIG welding where a thin layer of suitable activating flux is deposited on the parent components prior to constituting the arc in order to harness enhanced penetration. Despite several benefits, industries are still reluctant in overwhelmingly using this new variant. This article attempts to highlight the productivity benefits in employing A-TIG welding either together with or superseding TIG welding during butt joining of 10-mm-thick AISI-316L austenitic stainless steel components. Initially, three single-component fluxes (Cr2O3, Fe2O3, and SiO2) are tested in forehand welding technique under varying currents but with straight polarity. Filler rod having similar metallurgical composition is also delivered during homogeneous welding. The extent of capability of each of the three fluxes is analysed by comparing the weld bead geometrical parameters (penetration, puddle width, and reinforcement) with the same obtained in conventional TIG welding under similar set of parameters. While Fe2O3 and SiO2 fluxes are found capable in enhancing penetration and reducing puddle width and heat affected zone, Cr2O3 flux failed to exhibit better performance. The article further demonstrates the time saving that can be obtained by adopting flux-assisted TIG for joining 10-mm-thick plates. When joining from both the faces is allowed, about 70% less time is desired if a combination of A-TIG and TIG is employed rather than using only TIG welding. If joining from only one face is allowed, then also usage of flux can reduce welding time by 33%.
Uniqueness of optimal symplectic connections
Authors: Dervan Ruadhaí , Sektnan Lars Martin 
Published: March 2021

Abstract
Consider a holomorphic submersion between compact Kähler manifolds, such that each fibre admits a constantscalar curvature Kähler metric. When the fibres admit continuous automorphisms, a choice of fibrewise constant scalarcurvature Kähler metric is not unique. An optimal symplectic connection is a choice of fibrewise constant scalar curvature Kähler metric satisfying a geometric partial differential equation. The condition generalises the Hermite-Einstein condition for a holomorphic vector bundle through the induced fibrewise Fubini-Study metric on the associated projectivisation.
We prove various foundational analytic results concerning optimal symplectic connections. Our main result proves that optimal symplectic connections are unique, up to the action of the automorphism group of the submersion, when they exist. Thus optimal symplectic connections are canonical relatively Kähler metrics when they exist. In addition, we show that the existence of an optimal symplectic connection forces the automorphism group of the submersion to be reductive and that an optimal symplectic connection is automatically invariant under a maximal compact subgroup of this automorphism group. We also prove that when a submersion admits an optimal symplectic connection, it achieves the absolute minimum of a natural log norm functional, which we define.