bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deformation model and experimental evaluation of a contractable and bendable wire-pulling mechanism with embedded soft tubes for a robotic tongue
Authors: Endo Nobutsuna 
Published: February 2021

AbstractFew physical models of oral and laryngeal systems for human speech movement exist for computer or mechanical simulators. In particular, a robot tongue mechanism that fully reproduces the deformation motion of the human tongue is lacking. The human tongue is an aggregate of muscles that is devoid of a skeleton. It possesses only a small hyoid. A mechanism that can drive and control the deformation of a soft body, such as the human tongue, along multiple degrees of freedom has not been realized to date. To solve this problem, a wire-pulling mechanism with embedded soft tubes is proposed. Using this mechanism, a flexible tongue that can be deformed along multiple degrees of freedom without breaking the wire is achieved. A prototype planar mechanism with two degrees of freedom that is capable of contraction and bending was fabricated. A deformation model that assumes a piecewise constant curvature (PCC) was formulated. Deformation tests confirmed that the prototype is capable of contraction and bending movements that are consistent with those of the model. Variations in the error with respect to the hardness of the deformable part are discussed, and the limits of the deformation model based on the PCC assumption are presented.
Evaluation of SUVlean consistency in FDG and PSMA PET/MR with Dixon-, James-, and Janma-based lean body mass correction
Authors: Zhao Jun , Xue Qiaoyi , Chen Xing , You Zhiwen , Wang Zhe , Yuan Jianmin , Liu Hui , Hu Lingzhi 
Published: February 2021

Abstract
Purpose
To systematically evaluate the consistency of various standardized uptake value (SUV) lean body mass (LBM) normalization methods in a clinical positron emission tomography/magnetic resonance imaging (PET/MR) setting.

Methods
SUV of brain, liver, prostate, parotid, blood, and muscle were measured in 90 18F-FDG and 28 18F-PSMA PET/MR scans and corrected for LBM using the James, Janma (short for Janmahasatian), and Dixon approaches. The prospective study was performed from December 2018 to August 2020 at Shanghai East Hospital. Forty dual energy X-ray absorptiometry (DXA) measurements of non-fat mass were used as the reference standard. Agreement between different LBM methods was assessed by linear regression and Bland-Altman statistics. SUV’s dependency on BMI was evaluated by means of linear regression and Pearson correlation.

Results
Compared to DXA, the Dixon approach presented the least bias in LBM/weight% than James and Janma models (bias 0.4±7.3%, − 8.0±9.4%, and − 3.3±8.3% respectively). SUV normalized by body weight (SUVbw) was positively correlated with body mass index (BMI) for both FDG (e.g., liver: r = 0.45, p < 0.001) and PSMA scans (r = 0.20, p = 0.31), while SUV normalized by lean body mass (SUVlean) revealed a decreased dependency on BMI (r = 0.22, 0.08, 0.14, p = 0.04, 0.46, 0.18 for Dixon, James, and Janma models, respectively). The liver SUVbw of obese/overweight patients was significantly larger (p < 0.001) than that of normal patients, whereas the bias was mostly eliminated in SUVlean. One-way ANOVA showed significant difference (p < 0.001) between SUVlean in major organs measured using Dixon method vs James and Janma models.

Conclusion
Significant systematic variation was found using different approaches to calculate SUVlean. A consistent correction method should be applied for serial PET/MR scans. The Dixon method provides the most accurate measure of LBM, yielding the least bias of all approaches when compared to DXA.
Laparoscopic assisted hydrocelectomy of the canal of Nuck: a case report
Authors: Wang Liming , Maejima Taku , Fukahori Susumu , Shun Katayose , Yoshikawa Daitaro , Kono Toru 
Published: February 2021

Abstract
Background
Accurate diagnosis and complete resection of hydrocele of canal of Nuck (HCN) is still a challenge for surgeons.

Case presentation
A 28-year-old woman presented with a suspected inguinal hernia due to swelling in her right groin and was introduced for surgical treatment. Computed tomography scan revealed local cyst formation in the right groin and eliminated intestinal incarceration. In order to further confirm the diagnosis, we used laparoscopic exploration; after excluding a combined hernia, HCN was surgically removed using a conventional anterior peritoneal approach and a mesh patch repair was not needed. Postoperative pathology results showed no endometriosis or malignancy.

Conclusions
Laparoscopic assisted anterior approach provides both an accurate intraoperative diagnosis and a quick complete resection of HCN; it is the preferred treatment for women of childbearing age with pure HCN.
Phytowaste as nutraceuticals in boosting public health
Authors: Dike Chinyere S. , Orish Chinna N. , Nwokocha Chukwuemeka R. , Sikoki Francis D. , Babatunde Bolaji B. , Frazzoli Chiara , Orisakwe Orish E. 
Published: February 2021

AbstractThe utilization of bioactive constituent of peels and seeds provide an effective, environment friendly and inexpensive therapy for different forms of human disease, and the production, improvement and documentation of novel nutraceuticals. This review systematically presents findings and further understanding of the reported benefits and therapeutic applications of peel and seed extracts on innovative cell culture and animal studies, as well as phased clinical human trial research. The extracts of seed and peels were reported to possess high quantities of bioactive substances with antioxidative, antidiabetic, hepatorenal protective, antithyroidal, anti-inflammatory, antibacterial, cardiovascular protective, neuro-protective effects, anticancer and wound healing activities. Therapeutic activities of the bioactive substances of peel and seed extracts include elevation of Superoxide dismutase (SOD), GSH-Px, t-GPx, Catalase and GST activities, with the suppression of MDA levels, hydroperoxide generation and lipid peroxidized products, the extracts also regulate inflammatory mediators and cytokines as they are reported to suppress the secretion of inflammatory cytokines, which include; IL-1β, PGE2, TGF-β and TNF-α and induces apoptosis and cell differentiation. This review revealed the therapeutic importance and best utilization of peels and seed extracts of fruits and vegetables.
Biocontrol potential of bacterial isolates from vermicompost and earthworm against the root-knot nematode Meloidogyne javanica infecting tomato plants
Authors: Rostami Mahsa , Karegar Akbar , Taghavi S. Mohsen 
Published: February 2021

Abstract
Background
Root-knot nematodes (Meloidogyne spp.) are the most destructive agricultural pests, which parasitize thousands of different plant species in the world. Using antagonistic bacteria can be a potential alternative to hazardous chemical nematicides. This study was conducted to evaluate the biocontrol activities of the bacteria isolated from vermicompost and earthworm against M. javanica in infected tomato plants.

Results
Seventeen bacteria were isolated from vermicompost and earthworm. Their antagonistic effects were tested against the root-knot nematode M. javanica in laboratory and in glasshouse experiments. In the preliminary screening test, 8 bacterial isolates significantly caused more than 50% decrease in reproduction factor (Rf) of the nematode on tomato plants. Six isolates with more than 60% reduction in the nematode Rf were selected and identified as follows: Lysinibacillus fusiformis C1, Bacillus megaterium C3, B. safensis VW3, Pseudomonas resinovorans VW4, Lysinibacillus sp. VW6, and Sphingobacterium daejeonense LV1 by 16S rRNA gene sequencing. The isolates B. megaterium C3, B. safensis VW3, P. resinovorans VW4, and L. fusiformis C1 inhibited the nematode egg hatching by 20–28%, and Lysinibacillus sp. VW6 and L. fusiformis C1 caused 15 and 20% mortality of the second-stage juveniles in vitro. In a glasshouse, the 6 bacterial isolates reduced the nematode Rf by 47–66%, and P. resinovorans VW4 was the most effective isolate. However, B. safensis VW3, B. megaterium C3, and L. fusiformis C1 had the best effect on plant growth.

Conclusions
Most of the bacteria isolated from earthworm or vermicompost had nematicidal properties. This study provided empirical evidence of the nematicidal potential of isolates Lysinibacillus fusiformis C1, Pseudomonas resinovorans VW4, and Sphingobacterium daejeonense LV1 and the antagonistic activities of Bacillus megaterium C3 and B. safensis VW3 against Meloidogyne javanica.
Flexibility and resilience of great tit (Parus major) gut microbiomes to changing diets
Authors: Bodawatta Kasun H. , Freiberga Inga , Puzejova Katerina , Sam Katerina , Poulsen Michael , Jønsson Knud A. 
Published: February 2021

Abstract
Background
Gut microbial communities play important roles in nutrient management and can change in response to host diets. The extent of this flexibility and the concomitant resilience is largely unknown in wild animals. To untangle the dynamics of avian-gut microbiome symbiosis associated with diet changes, we exposed Parus major (Great tits) fed with a standard diet (seeds and mealworms) to either a mixed (seeds, mealworms and fruits), a seed, or a mealworm diet for 4 weeks, and examined the flexibility of gut microbiomes to these compositionally different diets. To assess microbiome resilience (recovery potential), all individuals were subsequently reversed to a standard diet for another 4 weeks. Cloacal microbiomes were collected weekly and characterised through sequencing the v4 region of the 16S rRNA gene using Illumina MiSeq.

Results
Initial microbiomes changed significantly with the diet manipulation, but the communities did not differ significantly between the three diet groups (mixed, seed and mealworm), despite multiple diet-specific changes in certain bacterial genera. Reverting birds to the standard diet led only to a partial recovery in gut community compositions. The majority of the bacterial taxa that increased significantly during diet manipulation decreased in relative abundance after reversion to the standard diet; however, bacterial taxa that decreased during the manipulation rarely increased after diet reversal

Conclusions
The gut microbial response and partial resilience to dietary changes support that gut bacterial communities of P. major play a role in accommodating dietary changes experienced by wild avian hosts. This may be a contributing factor to the relaxed association between microbiome composition and the bird phylogeny. Our findings further imply that interpretations of wild bird gut microbiome analyses from single-time point sampling, especially for omnivorous species or species with seasonally changing diets, should be done with caution. The partial community recovery implies that ecologically relevant diet changes (e.g., seasonality and migration) open up gut niches that may be filled by previously abundant microbes or replaced by different symbiont lineages, which has important implications for the integrity and specificity of long-term avian-symbiont associations.
An optimistic point in COVID-19 pandemic: a case report of large adult congenital cystic adenomatoid malformation
Authors: Kathar Hussain Mohamed rafi , Kulasekeran N. , Anand A. M. 
Published: February 2021

Abstract
Background
Covid-19 pandemic is a major health calamity causing global crisis involving every aspect of the society. CT chest has become an essential diagnostic investigation and as a prognostic tool for assessment for COVID-19 bronchopneumonia. This case report is about an incidental unexpected finding in a young female, who underwent CT chest screening with suspicion of COVID-19 bronchopneumonia.

Case presentation
A 29-year-old female came with the complaints of sore throat, myalgia, and fever for the past 3 days. She was referred to our department for plain screening CT chest to rule out COVID 19 infection. She was an active sports person since childhood. CT chest revealed a large well-defined bullous cystic lesion of size 16 × 9.5 × 9.5 cm in the left lung lower lobe with partial sparing of its superior, anterior, and posterior basal segments. Imaging diagnosis of large bullous cystic lesion with emphysematous changes was made. No features of COVID 19 bronchopneumonia. Thoracoscopy-guided lobectomy was done, and tissue was sent to histopathological examination. Final diagnosis was large type 1 congenital cystic adenomatoid malformation with mucinous metaplasia. Our case is unique in the sense that large adult CCAM with mucinous metaplasia of the epithelium is a rare presentation. Further it was diagnosed as a part of COVID 19 screening.

Conclusion
CCAM presentation in adult is rare. Asymptomatic CCAM lesion of this size diagnosed during COVID 19 chest CT screening was rarely described.
Localized Erdheim-Chester disease involving the thyroid gland—a case report
Authors: Singh Anup , Gautam Dheeraj , Gautam Poonam , Haq Mubashshirul , Handa Aru Chhabra , Handa Kumud Kumar 
Published: February 2021

Abstract
Background
Erdheim-Chester disease (ECD) is a rare multisystemic histiocytic disorder of unknown etiology. Isolated neck involvement has not been reported in literature.

Case presentation
An elderly male presented to our outpatient department with neck swelling of 1-month duration. Contrast-enhanced CT scan of the neck showed a mass involving the left thyroid/perithyroidal tissue with encirclement of the common carotid artery. Tru-Cut biopsy with immunohistochemistry showed CD68+, CD1a- histiocytic infiltrates with Touton giant cells compatible with ECD. BRAFV600E mutation came out to be positive. PET-CT did not reveal involvement of any other body organs. After counseling for further treatment options, the patient chose to follow up without any active treatment. The disease has not progressed at a follow-up of 1 year.

Conclusion
We present a case of ECD involving the thyroid gland in isolation. Absence of other organ involvement should not deter the treating physician from considering the possibility of ECD. Immunohistochemistry and testing for BRAFV600E mutation are important from the diagnostic as well as potential therapeutic point of view.
Sinicisation and ethnicity: spatial characteristics of Shui vernacular architecture in Guizhou, Southwest China
Authors: Zhou Yizhi , Wei Miao 
Published: February 2021

AbstractThe Shui people are an ethnic minority living in southern mountainous areas of Guizhou Province, China; they have retained many vernacular houses with a history of over a century. Using spatial analysis software depthmapX to perform visibility graph analysis and field-of-view analysis with space syntax, we examined the sequence, organisation, and hierarchy of the living space in Shui residences. We found that those residences were influenced by external cultures, resulting in two types of plan layout: front-middle-back (type A) and left-middle-right (type B). Those two types of spatial combination were evident in two different line-of-sight axes. With type A, the hearth was the core and served as the daily living space of the family. With type B, the ancestral altar was the core and served as the ritual space. The historical coexistence and changing relationship of the two axes reflect cultural exchange between the Shui and Han as well as with other foreign cultures. This study concludes that the diversity of spatial forms that developed in different historical periods is an important attribute of Shui houses and those of other ethnic minorities in Southwest China.
Acute Kidney Injury and Renal Tubular Damage in Children With Type 1 Diabetes Mellitus Onset
Authors: Marzuillo Pierluigi , Iafusco Dario , Zanfardino Angela , Guarino Stefano , Piscopo Alessia , Casaburo Francesca , Capalbo Daniela , Ventre Maria , Arienzo Maria Rosaria , Cirillo Grazia , De Luca Picione Carla , Esposito Tiziana , Montaldo Paolo , Di Sessa Anna , Miraglia del Giudice Emanuele 
Published: February 2021

Abstract

Context
Acute kidney injury (AKI) and renal tubular damage (RTD), especially if complicated by acute tubular necrosis (ATN), could increase the risk of later chronic kidney disease. No prospective studies on AKI and RTD in children with type1diabetes mellitus (T1DM) onset are available.

Objectives
To evaluate the AKI and RTD prevalence and their rate and timing of recovery in children with T1DM onset.

Design
Prospective study.

Settings and patients
185 children were followed up after 14 days from T1DM onset. The patients who did not recover from AKI/RTD were followed-up 30 and 60 days later.

Main outcome measures
AKI was defined according to the KDIGO criteria. RTD was defined by abnormal urinary beta-2-microglobulin and/or neutrophil gelatinase-associated lipocalin and/or tubular reabsorption of phosphate &lt; 85% and/or fractional excretion of Na (FENa) &gt; 2%. ATN was defined by RTD+AKI, prerenal (P)-AKI by AKI+FENa &lt; 1%, and acute tubular damage (ATD) by RTD without AKI.

Results
Prevalence of diabetic ketoacidosis (DKA) and AKI were 51.4% and 43.8%, respectively. Prevalence of AKI in T1DM patients with and without DKA was 65.2% and 21.1%, respectively; 33.3% reached AKI stage 2, and 66.7% of patients reached AKI stage 1. RTD was evident in 136/185 (73.5%) patients (32.4% showed ATN; 11.4%, P-AKI; 29.7%, ATD). All patients with DKA or AKI presented with RTD. The physiological and biochemical parameters of AKI and RTD were normal again in all patients. The former within 14 days and the latter within 2months.

Conclusions
Most patients with T1DM onset may develop AKI and/or RTD, especially if presenting with DKA. Over time the physiological and biochemical parameters of AKI/RTD normalize in all patients.
Tumours and tumour-like lesions of joints: Differential diagnoses in a paediatric population compared to adults
Authors: Junaid Syed , Gnanananthan Vaishnavi , Malhotra Karan , Saifuddin Asif 
Published: February 2021

Objective:
To determine the differential diagnosis of intra-articular tumours and tumour-like lesions in a paediatric population compared to adults.

Methods:
Retrospective review of children up to the age of 18 years with suspected intra-articular tumours and tumour-like lesions referred to a specialist musculoskeletal oncology service from January 2019 to August 2020. Data recorded included patient age and gender, lesion location and morphology (based on the classification system of Adams et al.), and the final diagnosis made either by image-guided biopsy/resection or by clinical and imaging features. Comparison was then made with a group of adults presenting during the same period.

Results:
28 paediatric patients were included (12 males and 16 females with mean age 11.2 years, range 3–18 years). Joints involved were the knee (n = 22; 78.6%), ankle (n = 4; 14.3%), hip (n = 1; 3.6%) and elbow (n = 1; 3.6%). Lesion morphology was Type 1 (n = 18; 64.3%), Type 2 (n = 3; 10.7%), Type 3 (n = 1; 3.6%) and Type 4 (n = 5; 17.9%). Final diagnosis was made by image-guided biopsy/resection in 18 (64.3%) patients. The commonest neoplastic lesion was tenosynovial giant cell tumour (n = 11; 39.3%), followed by synovial haemangioma (n = 5; 17.9%). There was only a single malignant lesion, a case of synovial sarcoma. Of eight (28.6%) non-neoplastic lesions, three were diagnosed as juvenile idiopathic arthritis and three as non-specific synovitis. There was no difference compared to adults regarding gender, joint involved or lesion morphology, but there was a significant difference in final diagnoses (p &lt; 0.001). The range of intra-articular tumours and tumour-like lesions in children differs from that in adults, although tenosynovial giant cell tumour is the commonest diagnosis in both groups and malignant lesions are rare.

Advances in knowledgeart:
In our series, ~16% of tumours and tumour-like lesions of joints occur in the paediatric population. Tenosynovial giant cell tumour remains the commonest diagnosis in children as in adults. Synovial haemangioma and juvenile idiopathic arthritis were the next commonest diagnoses in children, while primary synovial chondromatosis and reactive synovitis were the next commonest diagnoses in adults. Malignant lesions are rare in both groups.
Too old to sedate: How old is too old?
Authors: Bradley Natalie 
Published: February 2021

The UK population is ageing with over a quarter of people predicted to be over 65 by 2040. People are retaining their teeth into old age, often having experienced complex restorative dental work over the years. The increasing complexity of dental treatment that older people require will create challenges for those who provide care for this population, including dental treatment under sedation or general anaesthesia. This article discusses the medical, dental and social considerations that need to be taken into account when planning dental care for older patients under sedation or general anaesthesia. CPD/Clinical Relevance: Dentists who provide sedation must be able to appropriately assess and manage their older patients safely if considering this method of pain and anxiety control for dental treatment.
Non-syndromic oligodontia in siblings: A spectrum of experience
Authors: Heggie Claudia , Gartshore L 
Published: February 2021

Non-syndromic oligodontia, the agenesis of six or more teeth, has a prevalence of 0.14–0.25%. Genetic, epigenetic and environmental influences affect expression. Three brothers presented with agenesis of 14, 21 and 23 permanent teeth, respectively. They were medically well, with no relevant family history. Each case presented with caries, microdontia and attritive tooth surface loss. Comprehensive care was delivered in each case by undergraduate dental students. Individualized prevention and stabilization were completed before referral for multidisciplinary long-term planning. Primary dental care practitioners are instrumental in delivering preventive care and stabilizing the dentition in cases of dental anomaly, while sharing care with specialist teams. CPD/Clinical Relevance: An unusual presentation of non-syndromic oligodontia relevant to primary dental care practitioners who are likely to provide the first clinical contact and referral to the wider multidisciplinary team.
Aesthetic smile makeover using direct composite restorations: A case report of interdental spacing and altered passive eruption
Authors: Ziv Tal 
Published: February 2021

Interdental space between anterior teeth is an aesthetic and a phonetic problem. While various treatment options are available, patients often have concerns regarding treatment invasiveness, duration of treatments, costs and long-term prognosis. This case report describes a step-by-step smile makeover with direct composite restorations in maxillary incisors and canines with interdental spaces, tooth size discrepancy and altered passive eruption. CPD/Clinical Relevance: Minimally invasive dentistry is an integral component of contemporary clinical practice With recent advances in innovative materials and improved clinical technique, attaining aesthetic results with a minimally invasive approach is highly achievable.