Blood Pressure Variability during Early‐Mid Pregnancy in Women Who Develop Preeclampsia: Association with Aortic Stiffness but not Baroreflex Sensitivity
Authors: Nuckols Virginia , Holwerda Seth , DuBose Lyndsey , O'Deen Allison , Stroud Amy , Luehrs Rachel , Brandt Debra , Santillan Mark , Grobe Justin L , Santillan Donna , Pierce Gary 
Published: June 2021

BackgroundPreeclampsia (PE) is associated with a four‐fold increased risk of developing hypertension later in life. Hemodynamic adaptations to normal pregnancy involve a reduction large artery (e.g., aortic) stiffness and changes in autonomic control such as reduced baroreflex sensitivity (BRS), both of which influence blood pressure variability (BPV). BPV is higher during late pregnancy in women who develop PE; however, it remains unclear the extent to which vascular stiffness and BRS contribute to BPV during pregnancy in women who develop PE. We hypothesized that beat‐to‐beat BPV would be elevated in early‐mid gestation in women who develop PE prior to the onset of clinical PE and that greater BPV would be related to lower BRS and higher aortic stiffness.MethodsNine women who developed PE in late 3rd trimester and fifty‐four healthy pregnancy controls (31 ± 1.4 vs 30 ± 0.4 yrs, p=0.18) were assessed in the 1st (12 ± 0.1 wks), 2nd (22 ± 0.3 wks) and 3rd trimester (32 ± 0.3 wks). BPV and BRS were measured continuously for 10 minutes by finger plethysmography and electrocardiography. BPV was calculated as the standard deviation of beat‐by‐beat mean arterial pressure. BRS was calculated as the change in R‐R interval per unit change in blood pressure (ms/mmHg) via the sequence technique. Large artery stiffness was measured by applanation tonometry expressed as carotid‐femoral pulse wave velocity (CFPWV).ResultsWomen who developed PE had higher BPV in the 1st (4.43 ± 0.6 vs 3.07 ± 0.1 mmHg, p=0.02) and 2nd (4.05 ± 0.4 vs 3.05 ± 0.1 mmHg, p=0.01) trimester after adjusting for mean arterial pressure (MAP), but not in the 3rd trimester (4.70 ± 0.7 vs 3.37 ± 0.1 mmHg, p=0.95). In the entire cohort (n=63), there were reductions in BRS (ms/mmHg) between the 1st (20.4 ± 1.1), 2nd (14.5 ± 1.1) and 3rd (11.9 ± 0.9) trimester (p<0.001), but BRS did not differ between PE or controls. Therefore, BPV was higher in PE compared with normal pregnancy and did not change while cardiovagal BRS was progressively reduced in both PE and normal pregnancy. Importantly, women who developed PE had higher CFPWV in the 1st (5.9 ± 0.3 vs 5.2 ± 0.1 m/s, p=0.02) and 3rd (6.1 ± 0.4 vs 5.0 ± 0.1 m/s, p<0.01) trimesters. After adjusting for MAP, CFPWV was correlated with BPV in women with PE (r=0.77, p<0.05) but not in controls (r=0.13, p=0.37) in the 1st trimester.ConclusionsBeat‐to‐beat BPV and aortic stiffness were elevated during early‐mid pregnancy in PE while cardiovagal BRS was reduced similarly in women with PE and normal pregnancy. Therefore, these preliminary findings suggest that higher aortic stiffness may be an important contributor to dysregulation of blood pressure in women that develop PE.Support or Funding InformationAHA 15SFRN2373000This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.