bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal Characterization of Cytokine Overproduction: A Case Report in Critically Ill COVID-19 Patients With Hyperinflammation in Bronchoalveolar Lavage
Authors: Luo Zhen , Zhu Chengliang , Ruan Zhihui , Cui Xianghua , Shereen Muhammad Adnan , Pan Pan , Huang Jingtao , Wang Fubing , Su Hanwen , Xia Yuchen , Wu Jianguo 
Published: September 2021

Objectives: The longitudinal characterization and risk of poor outcomes related to cytokine overproduction in critical coronavirus disease 2019 (COVID-19) patients with hyperinflammation in bronchoalveolar lavage requires further investigation.Methods: We enrolled two critically ill patients with comorbidities diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detected by RT-PCR during hospitalization. Clinical characteristics, longitudinal immunological, and biochemical parameters of each critical COVID-19 case were collected.Main Results: The clinical characteristics and laboratory results of each case demonstrated critical symptoms of COVID-19 with poor outcomes. Both nasopharyngeal swabs and bronchoalveolar lavage fluid (BALF) samples tested positive for SARS-CoV-2. Two patients received targeted treatments against pathogen infection and inflammation in addition to interventional therapies, except for Patient 2, who received an additional artificial liver system treatment. Hyperinflammation with a dominantly high level of IL-6 was observed in BALF samples from both critical cases with decreased T cell populations. High levels of cytokines and pathological parameters were successively maintained in Patient 1, but rapidly reduced at the late treatment stage in Patient 2. The outcome of Patient 1 is death, whereas the outcome of Patient 2 is recovery.Conclusions: This case report suggests that a high risk of poor outcomes was related to a heavily hyperinflammatory milieu in both the blood and lungs of critical COVID-19 patients. The artificial liver intervention on cytokines overproduction might be beneficial for the recovery of critical COVID-19 patients as a reliable therapy that can be coordinated with targeted treatments, which ought to be further tested in adequately designed and powered clinical trials.
Altered Brain Functional Network in Subtypes of Parkinson's Disease: A Dynamic Perspective
Authors: Zhu Junlan , Zeng Qiaoling , Shi Qiao , Li Jiao , Dong Shuwen , Lai Chao , Cheng Guanxun 
Published: September 2021

Background: Parkinson's disease (PD) is a highly heterogeneous disease, especially in the clinical characteristics and prognosis. The PD is divided into two subgroups: tremor-dominant phenotype and non-tremor-dominant phenotype. Previous studies reported abnormal changes between the two PD phenotypes by using the static functional connectivity analysis. However, the dynamic properties of brain networks between the two PD phenotypes are not yet clear. Therefore, we aimed to uncover the dynamic functional network connectivity (dFNC) between the two PD phenotypes at the subnetwork level, focusing on the temporal properties of dFNC and the variability of network efficiency.Methods: We investigated the resting-state functional MRI (fMRI) data from 29 tremor-dominant PD patients (PDTD), 25 non-tremor-dominant PD patients (PDNTD), and 20 healthy controls (HCs). Sliding window approach, k-means clustering, independent component analysis (ICA), and graph theory analysis were applied to analyze the dFNC. Furthermore, the relationship between alterations in the dynamic properties and clinical features was assessed.Results: The dFNC analyses identified four reoccurring states, one of them showing sparse connections (state I). PDTD patients stayed longer time in state I and showed increased FNC between BG and vSMN in state IV. Both PD phenotypes exhibited higher FNC between dSMN and FPN in state II and state III compared with the controls. PDNTD patients showed decreased FNC between BG and FPN but increased FNC in the bilateral FPN compared with both PDTD patients and controls. In addition, PDNTD patients exhibited greater variability in global network efficiency. Tremor scores were positively correlated with dwell time in state I along with increased FNC between BG and vSMN in state IV.Conclusions: This study explores the dFNC between the PDTD and PDNTD patients, which offers new evidence on the abnormal time-varying brain functional connectivity and their network destruction of the two PD phenotypes, and may help better understand the neural substrates underlying different types of PD.
Filipino Multicomponent Intervention to Maintain Cognitive Performance in High-Risk Population (FINOMAIN): Study Protocol for a Cluster Randomized Controlled Trial
Authors: Dominguez Jacqueline , de Guzman Ma. Fe , Chen S. H. Annabel , Sano Mary , Waldemar Gunhild , Phung Thien Kieu Thi 
Published: September 2021

Background: More than half of the people with dementia live in lower-middle income countries (LMIC), yet we lack research and evidence-based knowledge to guide health promotion and prevention strategies for cognitive decline. In the Philippines, the prevalence of mild cognitive impairment (MCI) and cardiovascular risk factors among older persons are high, making this population at high risk for developing dementia. This protocol describes a cluster randomized controlled trial that aims to investigate the efficacy of a multicomponent intervention to maintain cognitive performance among high-risk population.Methods: This is a cluster-randomized, two-arm, single-blind trial of a multicomponent intervention that combines dance called INDAK (Improving Neurocognition through Dance and Kinesthetics), nutrition counseling, and vascular risk management. The intervention arm will receive 12 months (1-h, twice per week) of INDAK and every 3 months of nutrition counseling and intensive vascular risk management and monitoring. The control group will receive the usual vascular care advice and referral. A total of 605 (20–25 clusters per arm) community-dwelling Filipino older adults aged ≥ 60 years old with MCI will participate in the study and will be assessed at baseline, 6th- and 12th-month follow-up. The primary outcome is cognitive performance assessed by the Alzheimer's Disease Assessment Scale—Cognitive (ADAS-Cog), Mnemonic Similarity Tasks (MST), and executive function composite (EFC). Secondary outcomes are functional connectivity assessed through brain imaging, and measures of behavioral, functional level, and quality of life.Discussion: The study aims to provide scientific evidence on a public health intervention that is contextualized in a community setting to reduce dementia risk among older adults with MCI. This model can be an ecological, low-cost, and effective program, thereby conducive to widespread implementation in the Philippines as well as in other low-resource settings with similar public health challenges. The pilot phase was underway with eight villages (clusters), but temporarily interrupted by the pandemic. The full study is anticipated to start after community restrictions are eased.
Hybrid MDM-PDM Based Ro-FSO System for Broadband Services by Incorporating Donut Modes Under Diverse Weather Conditions
Authors: Chaudhary Sushank , Wuttisittikulkij Lunchakorn , Nebhen Jamel , Tang Xuan , Saadi Muhammad , Al Otaibi Sattam , Althobaiti Ahmed , Sharma Abhishek , Choudhary Sunita 
Published: September 2021

High-speed data demand in sensitive locations has prompted new wireless technologies to grow in areas like hospitals for bio-sensor data transmission between doctors and patients. However, interference of electromagnetic spectrum or highly sensitive medical equipment in such locations can prevent radio waves which can further compromise the health of patients. Radio over Free Space Optics (Ro-FSO) can fulfil high-speed data demand in such locations without any such interference. However, the Ro-FSO performance is highly influenced by different adverse weather conditions, particularly haze and rainfall, which further cause attenuation in the transmission path of Ro-FSO systems. These atmospheric turbulences mainly affect the transmission link range of Ro-FSO systems. In this work, Ro-FSO system is designed by incorporating hybrid mode division multiplexing (MDM) and polarization division multiplexing (PDM) schemes to deliver four independent channels, each carrying 10 Gbps data upconverted to 40 GHz radio signal, over 3.4 km free space optical link operating under clear weather conditions. In addition to this, the proposed Ro-FSO link is subjected to different weather conditions, particularly partially hazy/rainy and dense fog/very rainy. The reported results indicate the achievement of acceptable bit error rate (BER≈10–3) for all channels up to 3400m FSO link under clear weather conditions, 1000m under partially haze/rain and 620 m under dense fog/heavy rain.
Translation, Adaption, and Psychometric Testing of the Myanmar Version of the Medical Outcomes Study Social Support Survey for People Living With HIV/AIDS
Authors: Huang Feifei , Chen Wei-Ti , Lin Sai Htun , Tun Min San , Nwe Thet Wai , Oo Yin Thet Nu , Oo Htun Nyunt 
Published: September 2021

Introduction: Valid and reliable instruments are crucial for measuring perceived social support among people living with HIV (PLHIV). We aimed to investigate the psychometric properties of the English version of the 19-item Medical Outcomes Study Social Support Survey (MOS-SSS) adapted for PLHIV in Myanmar.Methods: Based on a standard cross-cultural procedure, we adapted the MOS-SSS and formed a Myanmar version of the scale (MOS-SSS-M), and then tested its validity and reliability. A sample of 250 eligible PLHIV was collected from a closed Facebook group that included more than 10,000 Myanmars, most of whom were PLHIV.Results: The MOS-SSS-M achieved a Cronbach’s α of 0.82–0.95. Confirmatory factor analysis revealed an acceptable fit index for the four-factor structure. Construct validity was demonstrated by significant association with self-reported HIV stigma and stress levels, and further confirmed by the findings of Rasch analysis.Conclusion: The MOS-SSS-M with a four-factor structure can be used to measure the level and categories of perceived social support among PLHIV in Myanmar.
Association of Circulating ANGPTL8 Levels With Renal Dysfunction: A Case-Control Study
Authors: Meng Xiaoyu , Zou Huajie , Li Danpei , Yu Peng , Huang Li , Zhang Jianhua , Li Wenjun , Yu Xuefeng 
Published: September 2021

Background: Chronic kidney disease (CKD) is recognized as a major public health problem with high morbidity and mortality worldwide. Recently, angiopoietin-like protein 8 (ANGPTL8) was found to regulate lipid metabolism. Previous studies suggested that serum ANGPTL8 levels increased in patients with diabetes, especially in diabetic patients with albuminuria. This study aimed to investigate the association between circulating levels of ANGPTL8 and kidney function in the general population.Methods: The subjects were patients with renal dysfunction [estimated glomerular filtration rate (eGFR) &lt;60/min/1.73 m2] from Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study (the REACTION study). Each case was matched by age, sex, and body mass index (BMI) with one control whose eGFR was ≥ 90 ml/min/1.73 m2. The case and control groups were compared using a paired t-test. Binary logistic regression analysis was used to calculate the odds ratio (OR) of renal dysfunction (RD).Results: Among 135 case-control pairs, circulating ANGPTL8 levels were elevated in patients with RD compared to control subjects [799.96 (410.12-1086.44) vs. 609.58 (365.13-740.06) pg/ml, p &lt; 0.05]. Partial correlations showed that ANGPTL8 levels were negatively correlated with eGFR (r = −0.26, p &lt; 0.05). Multivariable-adjusted binary logistic regression analysis showed that elevated ANGPTL8 levels were associated with an increased risk of RD (OR in quartile 4 vs. 1, 3.80; 95% CI, 1.71-8.41). Interestingly, the association between ANGPTL8 levels and RD was consistent with the overall findings in both nondiabetic individuals (OR, 1.44; 95% CI, 1.09 to 1.91) and diabetic patients (OR, 2.71; 95% CI, 1.13-6.49) in the subgroup analyses. Furthermore, the estimates for this association were also significant in females (OR, 2.12; 95% CI, 1.33-3.37), individuals aged &gt; 60 years (OR, 1.55; 95% CI, 1.16-2.07), individuals with a BMI &lt;24 (OR, 1.66; 95% CI, 1.16-2.39), and individuals without hyperlipidaemia (OR, 1.61; 95% CI, 1.16-2.23) (all p-values &lt;0.05).Conclusion: Elevated circulating ANGPTL8 levels were associated with increased risk of RD in the general population, especially among females, individuals aged &gt; 60 years, individuals with a BMI &lt; 24, individuals without diabetes mellitus, individuals with diabetes mellitus (DM), and individuals without hyperlipidaemia. This finding implies that ANGPTL8 may play a role in the pathological process of RD.
The Effect of Laparoscopic Radical Hysterectomy Surgical Volume on Oncology Outcomes in Early-Stage Cervical Cancer
Authors: Li Pengfei , Liu Jiaqi , Wang Li , Kang Shang , Yang Ying , Guo Jianxin , Yao Jilong , Lu Anwei , Wang Zhonghai , Lin Bin , Li Zhiqiang , Bin Xiaonong , Lang Jinghe , Liu Ping , Chen Chunlin 
Published: September 2021

Purpose: To examine the association between surgical volume and surgical and oncological outcomes of women with stage IB1 cervical cancer who underwent laparoscopic radical hysterectomy (LRH).Methods: We retrospectively analyzed the oncological outcomes of 1,137 patients with stage IB1 cervical cancer receiving LRH from 2004 to 2016. The surgical volume for each surgeon was defined as low [fewer than 50 surgeries, n = 392(34.5%)], mid [51-100 surgeries, n = 315(27.7%)], and high [100 surgeries or more, n = 430(37.8%)]. Surgical volume-specific survival was examined with Kaplan–Meier analysis, multivariable analysis, and propensity score matching.Results: The operative times of the high-volume group (227.35 ± 7.796 min) were significantly shorter than that of the low- (272.77 ± 4.887 min, p &lt; 0.001) and mid-volume (255.86 ± 4.981 min, p &lt; 0.001) groups. Blood loss in the high-volume group (169.42 ± 8.714 ml) was significantly less than that in the low-volume group (219.24 ± 11.299 ml, p = 0.003). The 5-year disease-free survival (DFS) and overall survival (OS) in the low-volume, mid-volume, and high-volume groups were similar (DFS: 91.9, 86.7, and 89.2%, p = 0.102; OS: 96.4, 93.5, and 94.2%, p = 0.192). Multivariable analysis revealed surgical volume was not an independent risk factor for OS or DFS. The rate of intraoperative and postoperative complications was similar among the three groups (p = 0.210).Conclusions: Surgical volume of LRH may not be a prognostic factor for patients with stage IB1 cervical cancer. Surgery at high-volume surgeon is associated with decreased operative time and blood loss.
Social Well-Being of the Population of Russia During the Pandemic (Based on Sample Survey Data)
Authors: Davletshina L. A. , Sadovnikova N. A. , Bezrukov A. V. , Lebedinskaya O. G. 
Published: September 2021

The article present results of the authors’ study of the social well-being of the Russian population – an assessment of the population’s health and attitudes towards a healthy lifestyle amid viral pandemic, based on materials of the Rosstat sample surveys of 2019 and 2020 and data from the All-Russian survey conducted by the Russian Public Opinion Research Center (VCIOM) on 27 September 2020. The authors described the transformation of living conditions in the light of the complex epidemiological situation and the increase in coronavirus cases among the population. Changes in the health status of the Russian population were analyzed by individual age groups.The article assesses the strength of the relationship between the social well-being of the population by selected socio-demographic groups and the period of self-isolation, quarantine, or other restrictions imposed during the coronavirus pandemic in 2020. To solve this problem, demographic and socio-economic characteristics of respondents are presented, the distribution of responses according to the survey results is estimated, and the most signifcant factor characteristics are selected. Respondent replies were grouped according to the selected questions, including in the territorial context (by federal districts). To determine the strength of the relationship between the respondents' answers to the question and their gender or age distribution, the coefcients of mutual conjugacy and rank correlation coefcients were calculated and analyzed.Analysis of the changes in the social well-being of population for 2019–2020 and the assessment of the strength of the relationship between the discussed indicators (gender, wealth, territory of residence) revealed the parameters that form the diﬀerences. After comparing the health status of the Russian population as a whole and by age groups in 2019 and 2020 based on data of sample survey on population health status, the following points were identifed. With the expected assessment of the population health status in the age distribution (deterioration in the older ages and better health in the younger ones), it also remains unchanged that more than half of the respondents characterize their health status as «very good» and «good». Noteworthy is the fact that the assessment of the health status of the Russian population has improved during the year. It is evidenced from changes in the structure of respondent replies, even though population health status survey of 2020 was conducted in the middle of lockdown amid the continuing negative trends in coronavirus morbidity and mortality.
Socio-Economic and Demographic Analysis of Spatial Development of the Republic of Sakha (Yakutia)
Authors: Fomin M. V. , Bezverbny V. A. , Seleznyov I. A. , Schneiderman I. M. , Miriazov T. R. 
Published: September 2021

The article deals with several relevant socio-demographic issues in the largest by territory constituent entity of the Russian Federation – the Republic of Sakha (Yakutia), based on Rosstat data and information arrays obtained in the course of sociological study conducted in 2019 and 2020 by the staﬀ of the Department of Geo-Urban Studies and Spatial Demography of the Institute for Demographic Research (IDR FCTAS RAS).The introduction notes the relevance of the study and methodological approaches to the analysis of the problems under review.The frst part of the article describes the general economic and socio-demographic situation in the region. It demonstrates how the industry specialization of Yakutia determines the socio-economic policy in the region. It is noted that the developing mining industry, along with the construction of large infrastructure facilities, requires an inﬂux of labor resources.In the second part of the article, after formulating the concept of sampling within the framework of a sociological survey (a model using key characteristics of the general population, based on the principles of quota-proportional and territorial methods), the social status of the population, its migration moods, attitudes towards labor migrants from abroad are analyzed, as well as the economic situation in general and the dynamics of the development of key enterprises in the region.It is argued that, despite the active industrial development of the Republic of Sakha (Yakutia), the existing socio-economic problems in the future may inﬂuence the pace of spatial development of the region. First and foremost, it is a problem of migration outﬂows. Although the demographic indicators at the republic level are high, there is a division of the region's territory into a decreasing periphery and a growing centre. As in most other constituent entities of the Russian Federation, in Yakutia, there are processes of population concentration in the most prospective areas.The authors drew up conclusions and proposals which, in their view, oﬀer a targeted approach to developing programmes on improving the quality of life of the local population, establishing compensatory mechanisms in various spheres, taking into account the huge territory of the republic and its severe climatic conditions
KONTRIBUSI KONSEP TAKWIL ULAMA USHULIYYUN DALAM PEWARISAN BEDA AGAMA
Authors: Siti Zuhrotun Ni'mah Ni'mah , Hamidah Tutik 
Published: September 2021

Artikel ini membahas mengenai kontribusi dari konsep takwil para Ushuliyyun dalam kewarisan beda agama. Para Ushuliyyun mewariskan metode takwil dalam Istibath Ahkam sebagai salah satu metodologi hukum Islam. Takwil merupakan pengalihan dari makna dhahir pada makna yang tersembunyi berdasarkan dalil yang dapat dijangkau. Penelitian ini menggunakan kajian kepustakaan (library research) sebagai pendekatan dengan melakukan kajian pada berbagai bahan hukum mengenai konsep takwil dan interpretasinya dalam kewarisan beda agama. Kajian ini menghasilkan konsep takwil secara menyeluruh mengenai ketentuan dan syarat yang harus diketahui agar takwil yang dilakukan menjadi takwil yang maqbul. Adapun takwil yang tidak memiliki dalil dan hanya karena nafsu maka takwil ini tidak bisa diterima. Relevansi konsep takwil dengan penyelesaian permasalahan dalam masyarakat mengenai hukum Islam dapat diketahui salah satunya pada pengaplikasian takwil terhadap konsep pewarisan beda agama yang ditakwilkan sehingga menghasilkan makna bahwa larangan kewarisan beda agama itu hanya diperuntukkan bagi kafir harby. Serta seorang muslim juga tetap bisa menjadi ahli waris dari orang kafir.
Peran Strategis IAIN Ambon dan IAKN Ambon Dalam Merawat Toleransi Sosial dan Moderasi Beragama di Ambon Maluku
Authors: Mahyuddin032 Mahyuddin 
Published: September 2021

Toleransi dan moderasi di Indonesia merupakan suatu diskursus yang akhir-akhir ini begitu banyak diperbincangkan. Pemerintah tokoh-tokoh masyarakat, tidak terkecuali lembaga-lembaga pendidikan sangat aktif membangun narasi tersebut. Penelitian ini bertujuan untuk menggambarkan peran Institut Agama Islam Negeri (IAIN) Ambon dan Institut Agama Kristen Negeri (IAKN) Ambon dalam merawat toleransi sosial dan moderasi beragama. Artikel ini menggunakan metode penelitian kualitatif. Penulis mengumpulkan data melalui wawancara, observasi dan dokumentasi. Hasil penelitian ini menunjukkan bahwa konsekuensi konflik agama masa lalu memengaruhi toleransi sosial dan moderasi beragama dalam masyarakat. Namun, ancaman ini dapat diurai oleh kedua lembaga pendidikan tinggi keagamaan dengan melakukan pendampingan dan pembimbingan kepada masyarakat luas tentang pentingnya merawat keharmonian dalam keberbedaan. Dalam upaya meretas perbedaan dan antagonisme di dalam masyarakat, masyarakat Ambon semakin terbuka diubah menjadi “kerukunan hidup” dan keluar dari dunia “kecurigaan dan permusuhan” meskipun hubungan kelompok-kelompok penganut agama masih menyimpan potensi kuat berulangnya gesekan sosial yang melibatkan dua kelompok agama.
Nganjuk’s Inter-Religious Harmony Forum (FKUB) in Handling House of Worship Permit Disputes of Gereja Sidang Jemaah Allah (GSJA) in Kanakan, Nganjuk
Authors: Effendy Gita Ajeng , Mahfud Agus 
Published: September 2021

Tujuan penelitian ini untuk mengetahui gambaran dalam dilapangan penyelesaian konflik pembangunan rumah ibadah yang ditangai dibawah naungan FKUB (Fokum Kerukunan Umat Beragama). Penelitian ini menggunakan metode kuaitattid deskriptif, dengan menggunakan perpose sampling untuk penelitian. Teori yang digunakan perpektif Talcot Parson mengenai teori aksi yang tertuju pada struktural fungsional. Parson, melihat dengan teori aksi bahwa anggota dari FKUB berupaya menjadi seorang volunter yang mampu menyelesaikan masalah dengan konsensus bersama. Anggota FKUB, dalam menyelesaikan juga menggunakan beberapa cara yang tidak menggar norma dan aturan yang berlaku dimasyarakat. Adanya FKUB mampu memberikan jawaban penyelesaian yang cukup musyawarah bagi masyarakat.