bluuebunny/crossref_metadata_2025_split huggingface dataset:
Literature and the Right to Be Human
Authors: Gikandi Simon 
Published: January 2021

In memory of my beloved mother, Charity Gakure, 1935-2019.
Thaayũ.
Wherever something stands, something else will
stand beside it. Nothing is absolute.
—Igbo Proverb
I accept Brecht's thesis that in settled periods of
history, culture—and literature which is its part, with
criticism as its partner—can reflect reality. But that in
traumatic times like ours, when reality itself is so distorted
as to have become impossible and abnormal, it is the function of
all culture, partaking of this abnormality, to be aware of its
own sickness. To be aware of the unreality of the unauthenticity
of the so called real, is to reinterpret this reality. To
reinterpret this reality is to commit oneself to a constant
revolutionary assault against it.
—Sylvia Wynter,
“We Must Learn to Sit Together and Talk about a Little
Culture”

As I was preparing this address, I struggled with the problem of what
Edward Said called beginnings and the complex set of circumstances that they
entail: “What must one do to begin? What is special about beginning as an
activity or a moment or a place? Can one begin whenever one pleases?” (xv).
This challenge can be exacerbated by one's relationship to institutions and
their history—in my case, the joy and pain of being both an insider and an
outsider, a scholar of Euro-American culture from its margins. And so
tonight I find myself in a situation that calls for celebration, but also in
a place of uncertainty. I, Simon Gikandi, born in a colonial state of
emergency, have had the luck to serve as the 129th president of the Modern
Language Association of America. My sense of good fortune is, however,
tempered by the reality that the state of emergency that characterized most
of the twentieth century, including the circumstances of my own beginnings,
has not gone away, as many of us had hoped, but has instead become
permanent. Everywhere I go around the world, I keep on hearing echoes of
Walter Benjamin's prediction that the state of emergency is “not the
exception but the rule” and of his injunction that we must “attain a
conception of history that is in keeping with this insight” (257). I find
myself in a world where achievement and precarity go hand in hand.
Renal AAV2-Mediated Overexpression of Long Non-Coding RNA H19 Attenuates Ischemic Acute Kidney Injury Through Sponging of microRNA-30a-5p
Authors: Haddad George , Kölling Malte , Wegmann Urs A. , Dettling Angela , Seeger Harald , Schmitt Roland , Soerensen-Zender Inga , Haller Hermann , Kistler Andreas D. , Dueck Anne , Engelhardt Stefan , Thum Thomas , Mueller Thomas F. , Wüthrich Rudolf P. , Lorenzen Johan M. 
Published: January 2021

Background
Renal ischemia-reperfusion (I/R) injury is a major cause of AKI. Noncoding RNAs are intricately involved in the pathophysiology of this form of AKI. Transcription of hypoxia-induced, long noncoding RNA H19, which shows high embryonic expression and is silenced in adults, is upregulated in renal I/R injury.

Methods
Lentivirus-mediated overexpression, as well as antisense oligonucleotide-based silencing, modulated H19 in vitro. In vivo analyses used constitutive H19 knockout mice. In addition, renal vein injection of adeno-associated virus 2 (AAV2) carrying H19 caused overexpression in the kidney. Expression of H19 in kidney transplant patients with I/R injury was investigated.

Results

H19 is upregulated in kidney biopsies of patients with AKI, in murine ischemic kidney tissue, and in cultured and ex vivo sorted hypoxic endothelial cells (ECs) and tubular epithelial cells (TECs). Transcription factors hypoxia-inducible factor 1-α, LHX8, and SPI1 activate H19 in ECs and TECs. H19 overexpression promotes angiogenesis in vitro and in vivo. In vivo, transient AAV2-mediated H19 overexpression significantly improved kidney function, reduced apoptosis, and reduced inflammation, as well as preserving capillary density and tubular epithelial integrity. Sponging of miR-30a-5p mediated the effects, which, in turn, led to target regulation of Dll4, ATG5, and Snai1.

Conclusions

H19 overexpression confers protection against renal injury by stimulating proangiogenic signaling. H19 overexpression may be a promising future therapeutic option in the treatment of patients with ischemic AKI.
Administration of and Prescribing Opioids in Emergency Departments: A Retrospective Study
Authors: McNeil Casey , Habib Alma , Okut Hayrettin , Beard Sheryl , Ablah Elizabeth , Hassouneh Stephanie 
Published: January 2021

Opioid overdose was a cause of 42,249 deaths in the United States in 2016 (13.3 deaths per 100,000) and contributed to 67.8% of all drug overdose deaths in the USA in 2017.1,2 The rate of drug overdose resulting in death in Kansas in 2016 was 11.8 per 100,000, (333 total drug overdose deaths).2 Emergency departments (EDs) are a key intermediary in opioid prescriptions. In 2010, 31% of ED visits nationally resulted in an opioid prescription.3
The number of opioid prescriptions from an ED varies greatly even for a single medical indication. For example, states varied from 40% to 2.8% of patients being prescribed an opioid medication from the ED for ankle sprains among opioid-naive patients treated from 2011 to 2015.4 In Kansas, 35.7% of ankle sprain patients received an opioid prescription from an ED.4
Guidelines for acute pain, including the Alternatives To Opioids protocol (ALTO)5 and the Center for Disease Control and Prevention’s Chronic Pain Guidelines (CDC-CPG)6 are available to guide opioid medication decisions. The ALTO protocol can be used to guide administration and prescription of analgesics for indications that include headache/migraine, musculoskeletal pain, renal colic, abdominal pain, bone fracture, and joint dislocation. The protocol encourages the use of analgesics such as acetaminophen, ibuprofen, and ketorolac prior to opioid administration.5 The CDC-CPG guides the provider into setting goals for pain control, discussing appropriate risks and benefits with the patients, and setting criteria for minimizing long-term opioid use,6 but defers to the American College of Emergency Physician’s 2012 clinical policy guideline for opioid management of chronic pain in the ED. The ACEP recommends against prescribing opioids for acute exacerbation of chronic pain in the ED [Level C recommendation].7
Adopting opioid prescribing guidelines has drastically reduced opioid prescribing rates in some locations.8 For example, a study performed in both a community and an academic medical center tested the implementation of an opioid prescribing guideline that resulted in a decline of opioid prescriptions from 52.7% to 29.8% of patient visits.8 Even in a hospital with less frequent opioid prescribing practices, adopting guidelines has reduced opioid administration in the ED from 22.5% to 17.7%.9 In 2017, 17 states had adopted opioid prescription guidelines10; however, Kansas is not one of those states.
Knowing little of opioid prescribing practices in Wichita, Kansas, the purpose of this study was to identify factors that are associated with opioid administration and prescriptions in EDs in Wichita, Kansas, and to evaluate what methods are used by local prescribers to limit opioid administration and prescription in a locality without an opioid prescribing guideline.
Validation transculturelle d’une échelle de mesure des compétences sociales chez les élèves des 8 à 12 ans
Authors: Simar Carine , Pironom Julie , Tessier Damien , Nsambu Christelle , Masson Julien 
Published: January 2021

La notion de compétences psychosociale (CPS) a été introduite par l’OMS en 1993 et définie comme « la capacité d’une personne à répondre avec efficacité aux exigences et aux épreuves de la vie quotidienne. C’est la capacité d’une personne à maintenir un état de bien-être subjectif qui lui permet d’adopter un comportement approprié et positif à l’occasion d’interactions avec les autres, sa culture, son environnement. ». Aujourd’hui, les compétences psychosociales bénéficient de plus en plus de recherches et sont reconnues comme un déterminant solide du bien-être et donc plus largement de la santé des élèves. Si des programmes scolaires permettant de les développer voient le jour, il semblerait qu’il n’existe pas d’échelle psychométrique permettant de les mesurer. Cet article propose donc la validation d’une échelle de mesure de la compétence « sociale » des CPS, en langue française, pour un public âgé d’au moins 8 ans. Pour ce faire, un recueil auprès de 614 élèves de cycle 3 (CM1-CM2-6ème), âgés de 8 à 12 ans (moyenne = 9,71 ans et écart-type = 0,81) a été mené lors de l’année scolaire 2017-2018 dans le cadre d’un projet de recherche-intervention sur le développement des CPS. Les élèves ont complété un questionnaire auto-administré en classe créé à partir d’outils connexes existants. Après un traitement statistique (validité, fiabilité), il ressort que les propriétés psychométriques de l’échelle de mesure CPS relatives à la compétence « sociale » sont bonnes et permettent de la valider.
Poríferos asociados a rompeolas en el departamento de Sucre (Caribe colombiano)
Authors: David-Colón Jesús Daniel , Marin-Casas Dairo Humberto 
Published: January 2021

Las esponjas se encuentran en diversos sustratos duros, tanto naturales como artificiales. En estos últimos son pocos los estudios realizados en Colombia. En este trabajo se listan y describen brevemente las especies de esponjas asociadas con rompeolas en el departamento de Sucre. La recolección de las esponjas se hizo manualmente en tres espolones de Coveñas. Para la identificación se hicieron montajes de espículas y cortes histológicos gruesos y se consultó la literatura taxonómica relevante. Se encontraron 22 especies, agrupadas en 15 familias y ocho órdenes; de estos registros, ocho son nuevos para la ecorregión del golfo de Morrosquillo y diez para el departamento de Sucre. La riqueza de especies encontrada fue superior a la registrada en otros trabajos en el golfo de Morrosquillo. Estos resultados contribuyen a fortalecer el conocimiento de las esponjas en sustratos artificiales y su distribución geográfica en el Caribe colombiano.
Modelamiento por homología in silico de la quinoproteína glucosa deshidrogenasa unida a membrana en Pseudomonas fluorescens
Authors: Chalaraca-Vélez Julia Rosa , Gaviria Duverney 
Published: January 2021

Entre las aplicaciones del modelamiento por homología están la predicción de ligandos, el análisis de mutaciones, y las actividades catalíticas. Normalmente, el uso de varios moldes produce modelos más precisos en la medida en que capturan mejor las variantes estructurales entre todas las posibles conformaciones de las proteínas de una familia. El modelamiento comparativo es una estrategia útil cuando no se tiene información en las ases de datos y se quiere hacer un ensayo xperimental relacionado con la estructura y el funcionamiento de una proteína. En el presente trabajo se analizó estructural y funcionalmente la quinoproteína glucosa deshidrogenasa unida a la membrana (membrane-bound PQQ-dependent glucose dehydrogenase, mGDH, PQQ mGDH) en Pseudomonas fluorescens, reconocida como un microorganismo promotor del crecimiento vegetal y una de cuyas funciones es la solubilización de fosfatos inorgánicos catalizados mediante PQQ mGDH. Esta es la primera enzima que participa en la oxidación directa de la glucosa transformando la D-lucosa a D-gluconato, proceso que es el inicio en la producción de ácidos orgánicos implicados en la solubilización de fosfatos inorgánicos. A pesar de la gran cantidad de estudios con esta enzima, no se ha reportado la determinación de su estructura tridimensional de la enzima quinoproteína glucosa deshidrogenasa (PQQ-GDH) en la bacteria P. fluorescens. En este estudio se comparó la secuencia e la proteína con las reportadas en las bases de datos para otras especies del género Pseudomonas y se propuso un modelo tridimensional de la enzima PQQ mGDH en P. fluorescens mediante el modelamiento por homología para caracterizar su estructura secundaria, el dominio catalítico, y el sitio de unión al ofactor pirroloquinolina quinona (PQQ), así como los dominios funcionales presentes en la proteína.
Nueva propuesta de edades para el registro sedimentario de las formaciones Bocas y Jordán y su relación con el desarrollo de la actividad magmática del Grupo Plutónico de Santander (Cordillera Oriental, Colombia)
Authors: Alarcón Carlos M. , Clavijo-Torres Jairo , Mantilla-Figueroa Luis C. , Rodríguez Juan Guillermo 
Published: January 2021

Los estudios del registro geológico del Jurásico en los Andes Septentrionales de Colombia apuntan a que en este lapso se desarrolló de forma simultánea la actividad magmática, el metamorfismo y la sedimentación en este sector de la corteza. En el Macizo de Santander (Cordillera Oriental de Colombia) han quedado registrados vestigios de esta actividad magmática cuyos remanentes actuales se reconocen en mayor medida por la presencia de cuerpos ígneos plutónicos (Grupo Plutónico de Santander). Los nuevos estudios paleontológicos en lodolitas de la Formación Bocas han permitido la identificación preliminar de las especies de conchostracos Shipingia hebaozhaiensis, uestheria buravasi y Laxitextella multireticulata de una edad correspondiente al Triásico Tardío. La geocronología U/Pb en circones ígneos de una ignimbrita y una toba riolítica de la Formación Jordán indica edades de acumulación de 199,37±0,34 Ma y 198,49± 0,33 Ma, lo que posibilita asignar su edad al Jurásico Temprano. Estos nuevos resultados sugieren que los registros de la actividad volcánica en la Formación Jordán son coetáneos con el desarrollo y la génesis del Grupo Plutónico de Santander (de edad ~202-195 Ma).
A studio experience for new building design in Sivas Höllüklük Street
Authors: Koç Pınar , Tuztaşı Uğur 
Published: January 2021

The aim of the study is to develop new design insights with regard to a new building in the historical environment of Sivas in Central Turkey. For this purpose, traditional houses located on a main road known as Hollukluk Street in Sivas have been chosen as the study area and a method focusing on the concept of reference is applied within a studio setting. Consequently, design insights have been developed by analysing the study area on mass organisation, spatial organisation, frontal texture, tectonic fiction and compactness relations in terms of street texture. In this practice, it has been observed that the students tend to refer to the entrance axis as a design guide, use the horizontal and vertical lines of the mass and refer to the new design with reference to the tectonic components. The outputs of the studio are formed in terms of four design insights which are shared in the findings section. As a result, design information produced from context-defined practice was used as the constituent elements of the formal structure in the new building, and these also contributed to the improvement of the street silhouette within the existing built environment.

Keywords: Architectural studio, design, historical environment of Sivas, new building.
Intuition in music education
Authors: Kirliauskienė Rasa , Abramauskienė Jolanta 
Published: January 2021

This article analysed the role of intuition in music education. Since success needs insight and quick perception, otherwise called intuition, this article aimed to reveal how it is possible to achieve music teacher’s activity. Also, the content of the role of a contemporary music teacher was identified and five aspects were distinguished: significance as an educator and as an authority, the importance of teacher’s personality, creativity and value-based aspects. The research content of the role of a contemporary music teacher justifies the possibilities for intuition in music education and extends its boundaries. The content of the role of a contemporary music teacher revealed during the research substantiates possibilities of intuition in music education and expands its boundaries. The analysis of the research results is meaningful for the improvement of music education.

Keywords: Music education, the role of a contemporary music teacher, intuition.
Oral Sucrose for Neonatal Pain: Perception of Jordanian Nurses
Authors: Kassab Manal , Joseph Rachel , Alhammad Nancy , Mohammad Khitam I 
Published: January 2021

BackgroundNeonatal pain management using sucrose has been an established practice in Western countries. However, in the developing world, the practice is still not widely accepted. Neonatal nurses' perceptions about the neonatal pain experience and efficacy of oral sucrose may influence that decision.PurposeTo investigate Jordanian neonatal nurses' perceptions about the use of oral sucrose for neonatal pain.Design and SampleA cross-sectional descriptive design was used to collect data from 191 neonatal nurses working in 3 different hospital settings in northern and middle central Jordan.Main Outcome VariablesKnowledge and perception of Jordanian nurses about neonatal pain and oral sucrose and their relationship to demographic variables.ResultsMore than half of nurses had knowledge deficit about pain management. Fifty-five percent of the nurses had a positive perception toward pain assessment tools, and the majority indicated positive opinion toward oral sucrose usage. Demographic factors can impact their perceptions.
Comparison of Antropometry and Physical Abilities between Trained and Untrained Individuals in Second Growth Phase
Authors: Akbar Idzam Kholid , Purwanto Bambang , Setijono Hari 
Published: January 2021

The growth and development of the body goes through two phases of rapid growth. First phase (0-5 years) and second phase (10-17 years). This study aimed to compare anthropometry and physical abilities between trained and untrained individuals in the second rapid growth phase (adolescence). This research method used analytic observational with cross sectional design. The sample study used adolescents aged 14 years old, consisted of trained adolescent groups (n=25) and untrained adolescent groups (n=32), with categorized throught the International Physical Activity Questionnaires (IPAQ). Each group measured height, weight, chest circumference, vital lung capacity (VC), oxygen saturation (SpO2), heart rate resting, heart rate exercise, and VO2Max. The results of the different test between trained and untrained groups with a significance level of p<0.05 showed there were significant differences in body height (p=0.000), VC (p=0.000), SpO2 (p=0,001), heart rate rest (p=0.000), and VO2Max (p=0.000). There were no significant differences in body weight (p=0.053), chest circumference (p=0.226), and heart rate exercise (p=0.242). As a conclusion, anthropometry and physical abilities of trained individuals was greater than the untrained individuals in the second rapid growth phase (adolescence).
Changes on Serum Troponin T Level before and after Taking Standard Therapy Medication in Heart Failure Patients
Authors: Indrawijaya Yen Yen Ari , Suharjono Suharjono , Aminuddin Muhammad , Retnowati Endang , Rahman Gilang Mauladi 
Published: January 2021

Patients with advanced heart failure (NYHA FC III and IV heart failure) had positive cardiac troponin levels in previous cohort studies. In heart failure, cardiac troponin T (cTnT) is a biomarker that is sensitive to myocardial damage, especially myocardial necrosis. However, there is still little information regarding changes in cTnT levels during standard therapy. This prospective observational study is aimed at evaluating changes in cTnT levels before and after theadministration of standard therapy and evaluating symptom improvement before and after the administration of standard therapy in patients with severe heart failure. Measurement of cTnT levels and symptom improvement parameters before treatment was carried out on the first day of the inpatient and measurement after therapy was carried out on the last day of the inpatient. Sampling was done by consecutive sampling and found 30 patients in the inpatient room of the SMF Cardiovascular Disease, Dr. Soetomo Hospital, Surabaya during the months of May-July 2017. The results of the study obtained the average cTnT levels before therapy 33.48 + 31.88 pg/ml and the average cTnT levels after therapy 46.32 + 52.68 pg/ml. Based on the statistical difference test with the Wilcoxon sign-ranked test, there was no significant change in cTnT levels (p = 0.318). On the parameter of clinical symptom improvement, there was a significant decrease in pulse, respiratory rate, blood pressure, and mean arterial pressure before and after administration of therapy (p <0.05). There was no change in troponin T levels before and after the administration of therapy meant there was no worsening of myocardial necrosis.
Knowledge, Attitude and Practices of Self-Medication Among Community Pharmacy Consumers' Perspectives in Derna City, Libya
Authors: Asmaa Abdulaziz A. Rabee  , Raga A. Elzahaf  , Yahya Saber E. Mansour  , Nusieba A. Mohammed Ibrahim  
Published: January 2021

Self-medication may be associated with side effects and increases the chance of drug interactions and also affects the potency of treatment and quality of life. This study aims to estimate knowledge, attitude and pharmacy practices concerning the usage of the drugs without prescription and identifying demographic factors that could influence self-medication among the consumers of community pharmacy in Derna- Libya. Cross-sectional study was conducted among 389 participants randomly selected depending on multi-stage random sampling technique. Data were collected by using a structured questionnaire distributed over 10 different regions in Derna city. This study continued over2 months, in our result 215 (55.3%) of total participant used the self medication, most of them were male, the mean age of participants was 37.40±13.190 ranged from 14 to 83 years, most of participants 179(46%) were in university level, 235(60.4%) were in low-income level and 214(55%) were employee. In our result 111(28.5%) of participants had low level of knowledge regarding the safety of self-medication, 186 (47.8%) don’t known OTC medication and prescription only medication. Based on the attitude total score 215 participants had negative attitude toward self-medications, 159(40.9%) always purchase the medication without prescription, the most common reason for taking self-medication was that there was no need to visit the doctor for minor illness. And the most of medication dispensed without prescription were analgesics antipyretics for cases of cold and flu as well as in pain. Pharmacy practices were good, most of pharmacist provided information about drug interactions if taking this medicine without a prescription (84.6%) and did not face difficulties to find information about the medicine.