bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between oral dryness and use of dry-mouth interventions in Sjögren’s syndrome patients
Authors: Assy Z. , Bikker F. J. , Picauly O. , Brand H. S. 
Published: August 2021

Abstract
Objective
Sjögren’s syndrome patients use different dry-mouth interventions for the relieve of their oral dryness. Recently, it was shown that patients with dry-mouth complaints have regional differences in perceived intra-oral dryness. Therefore, the aim of the present study was to investigate whether the use of dry-mouth interventions is related to the perceived regional oral dryness.

Materials and methods
A cross-sectional study was performed among Sjögren’s patients. Volunteers could anonymously administer various questionnaires, including the Regional Oral Dryness Inventory (RODI), Xerostomia Inventory (XI), Bother Index (BI) and a list of dry-mouth interventions.

Results
Sjögren’s syndrome patients use a wide variety for the relieve of oral dryness. “Drinking water’’ and “moistening the lips’’ were used most frequently. Dry-mouth interventions, “drinking water’’, “rinsing of the mouth”, and “drinking small volumes” had significant associations with the RODI-scores of the posterior palate, and anterior and posterior tongue, respectively. On the other hand, “using mouth gel’’ had a significant association with the RODI-scores of the inside cheeks.

Conclusion
Sjögren’s syndrome patients are more likely to use mouth gels when their inside cheeks were experienced as most dry, while they drank water, rinsed their mouth or drank small volumes if the posterior palate, and anterior and posterior tongue were considered as dry. It can be concluded that intra-oral dryness affects dry-mouth perception and thereby also the use of the various dry-mouth interventions.

Clinical relevance
The therapeutic choice of dry-mouth interventions by Sjögren’s syndrome patients seems to some extent to be related to dryness at specific intra-oral regions.
Gilteritinib versus chemotherapy in Japanese patients with FLT3-mutated relapsed/refractory acute myeloid leukemia
Authors: Hosono Naoko , Yokoyama Hisayuki , Aotsuka Nobuyuki , Ando Kiyoshi , Iida Hiroatsu , Ishikawa Takayuki , Usuki Kensuke , Onozawa Masahiro , Kizaki Masahiro , Kubo Kohmei , Kuroda Junya , Kobayashi Yukio , Shimizu Takayuki , Chiba Shigeru , Nara Miho , Hata Tomoko , Hidaka Michihiro , Fujiwara Shin-Ichiro , Maeda Yoshinobu , Morita Yasuyoshi , Kusano Mikiko , Lu Qiaoyang , Miyawaki Shuichi , Berrak Erhan , Hasabou Nahla , Naoe Tomoki 
Published: August 2021

Abstract
Background
Until recently, no effective targeted therapies for FLT3-mutated (FLT3mut+) relapsed/refractory (R/R) acute myeloid leukemia (AML) were available in Japan. The FLT3 inhibitor, gilteritinib, was approved in Japan for patients with FLT3mut+ R/R AML based on the phase 3 ADMIRAL trial, which demonstrated the superiority of gilteritinib over salvage chemotherapy (SC) with respect to overall survival (OS; median OS, 9.3 vs 5.6 months, respectively; hazard ratio, 0.64 [95% confidence interval 0.49, 0.83]; P < 0.001).

Methods
We evaluated the Japanese subgroup (n = 48) of the ADMIRAL trial, which included 33 patients randomized to 120-mg/day gilteritinib and 15 randomized to SC.

Results
Median OS was 14.3 months in the gilteritinib arm and 9.6 months in the SC arm. The complete remission/complete remission with partial hematologic recovery rate was higher in the gilteritinib arm (48.5%) than in the SC arm (13.3%). After adjustment for drug exposure, fewer adverse events (AEs) occurred in the gilteritinib arm than in the SC arm. Common grade ≥ 3 AEs related to gilteritinib were febrile neutropenia (36%), decreased platelet count (27%), and anemia (24%).

Conclusion
Findings in Japanese patients are consistent with those of the overall ADMIRAL study population.
A revised version of the Cathcart & El-Jahel model and its application to CDS market
Authors: Radi Davide , Hoang Vu Phuong , Torri Gabriele , Dvořáčková Hana 
Published: August 2021

AbstractThe paper considers the pricing of credit default swaps (CDSs) using a revised version of the credit risk model proposed in Cathcart and El-Jahel (2003). Default occurs either the first time a signaling process breaches a threshold barrier or unexpectedly at the first jump of a Cox process. The intensity of default depends on the risk-free interest rate, which follows a Vasicek process, instead of a Cox-Ingersoll-Ross process as in the original model. This offers two advantages. On the one hand, it allows us to account for negative interest rates which are recently observed, on the other hand, it simplifies the formula for pricing CDSs. The goodness of fit of the model is tested using a dataset of CDS credit spreads related to European companies. The results obtained show a rather satisfactory agreement between theoretical predictions and market data, which is identical to the one obtained with the original model. In addition, the values of the calibrated parameters result to be stable over time and the semi-closed form solution ensures a very fast implementation.
Impact of failed ab-interno trabeculectomy (trabectome) on subsequent XEN45 gel stent implantation in pseudophakic eyes
Authors: Kiessling D. , Rennings C. , Hild M. , Lappas A. , Dietlein T. S. , Roessler G. F. , Widder Randolf Alexander 
Published: August 2021

Abstract
Purpose
To determine the impact of failed ab-interno trabeculectomy on the postoperative outcome of subsequent XEN45 gel stent (Allergan, CA, USA) implantation in pseudophakic eyes.

Methods
In this retrospective single-center study, we included 60 pseudophakic eyes from 60 participants who underwent XEN45 gel stent implantation. Thirty eyes each underwent primary stent implantation (control group) or had previously undergone a failed ab-interno trabeculectomy (trabectome group). The groups were matched at a 1:1 ratio based on the following criteria: preoperative and maximum Intraocular pressure (IOP), preoperative medication score, cup/disk-ratio, follow-up time, best-corrected visual acuity at baseline, age, and the proportion of patients classified as primary open angle glaucoma or exfoliation glaucoma. We defined a successful surgery by the following three scores: an IOP reduction > 20% and IOP at the longest follow-up < 21 mmHg (Score A) or < 18 mmHg (Score B) or IOP ≤ 15 mmHg and an IOP reduction ≥ 40% (Score C). One open conjunctival revision was allowed in all scores, and a repeat surgery was considered a failure.

Results
Following an average follow-up period of 22 ± 12 months, we observed a mean IOP reduction of 38%, from 23.5 ± 5.2–14.5 ± 5.0 mmHg. Comparative analyses between the groups did not reveal a significant difference in the postoperative IOP, postoperative medication score, side effects, revision rate, repeat surgery rate, or success rate.

Conclusions
Trabectome is a viable first-line procedure for medically uncontrolled glaucoma before filtering ab-interno microstent surgery is considered.
Developmental Relations Between Internalising Problems and ADHD in Childhood: a Symptom Level Perspective
Authors: Speyer Lydia Gabriela , Eisner Manuel , Ribeaud Denis , Luciano Michelle , Auyeung Bonnie , Murray Aja Louise 
Published: August 2021

AbstractADHD and internalising problems commonly co-occur with up to 50% of children diagnosed with ADHD also suffering from anxiety or depression. However, their developmental relations are currently not well understood. Longitudinal symptom level analyses can provide valuable insights into how difficulties in these areas of psychosocial functioning affect each other. Using Gaussian Graphical Models and Graphical Vector Autoregression Models, this study estimated cross-sectional and longitudinal networks of ADHD and internalising symptoms in 1387 children using parent- and teacher-reported Social Behaviour Questionnaires (SBQ) when children were aged 7, 9 and 11. Cross-sectional and longitudinal networks suggested that ADHD shares reciprocal relations with internalising symptoms through a number of potential bridge symptoms that are primarily connected to anxiety symptoms. High scores on child cannot sit still, is restless, or hyperactive were found to be the strongest bridge symptom acting as an antecedent to higher internalising symptoms whereas child is worried was the strongest antecedent for higher ADHD symptoms. Findings of this study highlight several potential bridge symptoms that may serve as key intervention targets and further emphasise the need for clinicians to assess children presenting with ADHD symptoms for internalising problems and vice versa.
The fall in income inequality during COVID-19 in four European countries
Authors: Clark Andrew E. , D’Ambrosio Conchita , Lepinteur Anthony 
Published: August 2021

AbstractWe here use panel data from the COME-HERE survey to track income inequality during COVID-19 in France, Germany, Italy, and Spain. Relative inequality in equivalent household disposable income among individuals changed in a hump-shaped way between January 2020 and January 2021, with an initial rise from January to May 2020 being more than reversed by September 2020. Absolute inequality also fell over this period. Due to the pandemic some households lost more than others, and government compensation schemes were targeted towards the poorest, implying that on average income differences decreased. Generalized Lorenz domination reveals that these distributive changes reduced welfare in Italy.
Acculturation, Communication Competence, and Family Functioning in Mexican–American Mother–Daughter Dyads
Authors: Marquez Becky , Benitez Tanya , Lister Zephon 
Published: August 2021

AbstractLittle is known of how intergenerational acculturation discrepancy relates to communication skills differences that may influence relationship quality among parents and adult children. Mexican–American mother–daughter dyads (n = 59) were studied using the Actor Partner Interdependence Model to examine dyadic associations of acculturation and communication competence with family functioning and mediation analysis to determine the indirect effect of acculturation discrepancy on family functioning through communication competence differences. Communication competence of mothers exerted significant actor and partner effects on daughter-perceived cohesion and closeness. Higher acculturation discrepancy predicted greater communication competence difference which in turn was associated with lower cohesion and closeness. There was a significant indirect effect of acculturation discrepancy on daughter-perceived cohesion through communication competence difference. Communication competence of mothers impacts their own as well as their daughters’ perceptions of dyad cohesion and closeness. Intergenerational discrepant acculturation contributes to discordant communication skills that impair family functioning, which has implications for psychological well-being.
Formation of highly resistive SiO2 nanoparticle layers from the aerosol by electrostatic precipitation at 200 °C: observations on back corona and nanoparticle layer structure
Authors: Bürger Patrick , Riebel Ulrich 
Published: August 2021

AbstractIn this study, a flame-generated nm-range SiO2 aerosol (approx. 170 nm median aggregate diameter) is fed into an electrostatic precipitator with an operating temperature of 200 °C. While a highly porous layer of SiO2 nanoparticles (NPs) is deposited by electrostatic precipitation, a decrease of current uptake is observed initially, indicating exceptionally high values of the electric field within the layer (> 100 kV/mm) and of the layer resistivity (> 1013 Ω∙cm). Later a strong (13- to 17-fold) increase of current uptake is observed. Aerosol charge measurements show that charges of opposite polarity are emitted from the NP layer. Investigation of the NP layer by SEM shows that charge-emitting structures with a polarity-dependent morphology develop on an originally homogeneous NP layer. Based on the experimental evidence, the mechanisms of charge emission and structure formation are discussed. Charge emission from the precipitated dust layer is known as back corona in the field of electrostatic precipitation. It appears that the mechanisms of back corona observed with SiO2 NP layers are quite distinct from those observed with µm-range particles. While gas discharges inside the NP layer are suppressed due to small pore size, back corona inside the NP layers is apparently initiated by thermionic field emission of free electrons and secondary electron multiplication within the NP layer.
Emergent Bioanalogous Properties of Blockchain-based Distributed Systems
Authors: Abramov Oleg , Bebell Kirstin L. , Mojzsis Stephen J. 
Published: August 2021

AbstractWe apply a novel definition of biological systems to a series of reproducible observations on a blockchain-based distributed virtual machine (dVM). We find that such blockchain-based systems display a number of bioanalogous properties, such as response to the environment, growth and change, replication, and homeostasis, that fit some definitions of life. We further present a conceptual model for a simple self-sustaining, self-organizing, self-regulating distributed ‘organism’ as an operationally closed system that would fulfill all basic definitions and criteria for life, and describe developing technologies, particularly artificial neural network (ANN) based artificial intelligence (AI), that would enable it in the near future. Notably, such systems would have a number of specific advantages over biological life, such as the ability to pass acquired traits to offspring, significantly improved speed, accuracy, and redundancy of their genetic carrier, and potentially unlimited lifespans. Public blockchain-based dVMs provide an uncontained environment for the development of artificial general intelligence (AGI) with the capability to evolve by self-direction.
How the Geomagnetic Field Influences Life on Earth – An Integrated Approach to Geomagnetobiology
Authors: Erdmann Weronika , Kmita Hanna , Kosicki Jakub Z. , Kaczmarek Łukasz 
Published: August 2021

AbstractEarth is one of the inner planets of the Solar System, but – unlike the others – it has an oxidising atmosphere, relatively stable temperature, and a constant geomagnetic field (GMF). The GMF does not only protect life on Earth against the solar wind and cosmic rays, but it also shields the atmosphere itself, thus creating relatively stable environmental conditions. What is more, the GMF could have influenced the origins of life: organisms from archaea to plants and animals may have been using the GMF as a source of spatial information since the very beginning. Although the GMF is constant, it does undergo various changes, some of which, e.g. a reversal of the poles, weaken the field significantly or even lead to its short-term disappearance. This may result in considerable climatic changes and an increased frequency of mutations caused by the solar wind and cosmic radiation. This review analyses data on the influence of the GMF on different aspects of life and it also presents current knowledge in the area. In conclusion, the GMF has a positive impact on living organisms, whereas a diminishing or disappearing GMF negatively affects living organisms. The influence of the GMF may also be an important factor determining both survival of terrestrial organisms outside Earth and the emergence of life on other planets.
In Vitro Antioxidant Capacity of Opuntia spp. Fruits Measured by the LOX-FL Method and its High Sensitivity Towards Betalains
Authors: Gómez-Maqueo Andrea , Soccio Mario , Cano M. Pilar 
Published: August 2021

AbstractCurrent in vitro methodologies neglect or subestimate the contribution of betalains to antioxidant capacity in foods because they do not reflect their in vivo biological mechanisms. In this study, we assessed the sensibility of the lipoxygenase-fluorescein (LOX-FL) method towards betalains, phenolic compounds and ascorbic acid from Opuntia spp. fruits; and (ii) the antioxidant capacity of peel and pulp extracts from Opuntia ficus-indica L. Mill (var. Fresa, Colorada and Blanco) and Opuntia stricta var. Dillenii; by comparing the LOX-FL method to traditional antioxidant methods (ORAC and TEAC). The spectrophotometric monitoring of the LOX-FL reaction avoided interference caused by betalain pigments. Indicaxanthin and betanin showed high antiperoxidative and radical scavenging mechanisms in the LOX-FL assay. O. stricta var. Dillenii tissues the highest antioxidant capacity which correlated with betanin content. ORAC and TEAC antioxidant methods were less sensible towards betalain antioxidant activity. To our knowledge, this is the first time the LOX-FL antioxidant method has been used on betalains and betalain-rich foods.
Graphical Abstract
Differential stability properties in convex scalar and vector optimization
Authors: An D. T. V. , Gutiérrez C. 
Published: August 2021

AbstractThis paper focuses on formulas for theε-subdifferential of the optimal value function of scalar and vector convex optimization problems. These formulas can be applied when the set of solutions of the problem is empty. In the scalar case, both unconstrained problems and problems with an inclusion constraint are considered. For the last ones, limiting results are derived, in such a way that no qualification conditions are required. The main mathematical tool is a limiting calculus rule for theε-subdifferential of the sum of convex and lower semicontinuous functions defined on a (non necessarily reflexive) Banach space. In the vector case, unconstrained problems are studied and exact formulas are derived by linear scalarizations. These results are based on a concept of infimal set, the notion of cone proper set and anε-subdifferential for convex vector functions due to Taa.
Technological, functional and safety properties of lactobacilli isolates from soft wheat sourdough and their potential use as antimould cultures
Authors: Mota-Gutierrez Jatziri , Franciosa Irene , Ruggirello Marianna , Dolci Paola 
Published: August 2021

AbstractBakery products are a common medium for fungal growth due to their high-water activity and nutrients availability. The application of lactic acid bacteria (LAB) isolated from wheat bran or other cereals has shown great potential in controlling the growth of spoilage fungi, guarantee quality and prolong the shelf life of bakery products. This study outlines the antifungal, technological, functional and safety properties of autochthonous LAB microbiota isolated from type 0 soft wheat sourdough fermentation. Antifungal activity of 77 LAB belonging to Lactiplantibacillus plantarum and Lacticaseibacillus casei species isolated from spontaneous sourdough fermentation was tested in vitro against 16 spoilage fungi. Our findings demonstrated that the antifungal activity, enzymatic and safety properties of LAB isolates vary strain-dependently. Four LAB isolates (Lp. plantarum A16, A25, B11, and B15) showed the best traits, in particular strong antifungal activity and good capabilities to produce exopolysaccharides from different carbon sources in vitro. Care should be taken when using Lp. plantarum A310 and B18 and Lc. casei A23, as starter cultures, since these isolates exhibited a multiple antibiotic-resistance. Here we showed the promising potential of different LAB isolates as bio-preservative agents and to provide new insights regarding their prospective use as starter cultures to guarantee safety and palatability.
Graphic abstract
Molecular biomarker responses in the freshwater mussel Anodonta anatina exposed to an industrial wastewater effluent
Authors: Ekelund Ugge Gustaf MO , Jonsson Annie , Berglund Olof 
Published: August 2021

AbstractUsing a selection of molecular biomarkers, we evaluated responses in freshwater mussels (Anodonta anatina) exposed to effluent from an industrial wastewater treatment facility. The aims of this work were to (1) assess biomarkers of general toxicity under sublethal exposure to an anthropogenic mixture of chemicals, represented by an arbitrary effluent, and (2) evaluate the potential ofA. anatinaas a bioindicator of pollution. Adult mussels (n =in total 32; 24 males and 8 females) were exposed (96 h) in the laboratory to a fixed dilution of effluent or to a control treatment of standardized freshwater. Metal concentrations were in general higher in the effluent, by an order of magnitude or more, compared to the control. Toxic unit estimates were used as proxies of chemical stress, and Cu, Ni, and Zn were identified as potential major contributors (Cu> Ni > Zn). Six transcriptional (cat,gst,hsp70,hsp90,mt,sod) and two biochemical (AChE, GST) biomarkers were analyzed in two tissues, gills, and digestive glands. Out of the 16 responses (eight biomarkers × two tissues), 14 effect sizes were small (within ± 28 % of control) and differences non-significant (p> 0.05). Results did however show that (1) AChE activity increased by 40% in gills of exposed mussels compared to control, (2)hsp90expression was 100% higher in exposed female gills compared to control, and (3) three marker signals (AChE in both tissues, andhsp70in gills) differed between sexes, independent of treatment. Results highlight a need for further investigation of molecular biomarker variability and robustness inA. anatina.
Characterisation of inorganic constitutions of condensate and solid residue generated from small-scale ex situ experiments in the context of underground coal gasification
Authors: Sadasivam Sivachidambaram , Zagorščak Renato , Thomas Hywel Rhys , Kapusta Krzysztof , Stańczyk Krzysztof 
Published: August 2021

AbstractThis paper deals with the characterisation of inorganic constitutions generated at various operating conditions in the context of underground coal gasification (UCG). The ex situ small-scale experiments were conducted with coal specimens of different rank, from the South Wales Coalfield, Wales, UK, and Upper Silesian Coal Basin, Poland. The experiments were conducted at various gaseous oxidant ratios (water: oxygen = 1:1 and 2:1), pressures (20 bar and 36 bar) and temperatures (650°C, 750°C and 850°C). Increasing the amount of water in the oxidants proportionately decreased the cationic elements but increased the concentrations of anionic species. The temperature played minor impact, while the high-pressure experiments at temperature optimum to produce methane-rich syngas (750°C) showed significant reduction in cationic element generation. However, both coal specimens produced high amount of anionic species (F, Cl, SO4 and NO3). The “Hard” bituminous coal from Poland produced less gasification residues and condensates than the South Wales anthracitic coal due to its higher reactivity. The inorganic composition found in the solid residue was used in the theoretical calculation to predict the dissolved product concentrations when the solid residue interacts with deep coal seam water in the event of UCG cavity flooding. It was evident from the solubility products of the Cr, Ni and Zn that changes in the groundwater geochemistry occur; hence, their transportation in the subsurface must be studied further.