bluuebunny/crossref_metadata_2025_split huggingface dataset:
Petrotectonic origin of mafic eclogites from the Maksyutov subduction complex, south Ural Mountains, Russia
Authors: Fedkin Valentin V. , Burlick Theodore D. , Leech* Mary L. , Shchipansky Andrey A. , Valizer Peter M. , Ernst W.G. 
Published: August 2021

ABSTRACT
The Maksyutov complex is a mid- to late-Paleozoic high- to ultrahigh-pressure (HP-UHP) eclogite-bearing subduction zone terrane in the south Ural Mountains. Previous reports of radial fractures emanating from quartz inclusions in garnet, omphacite, and glaucophane, cuboid graphite pseudomorphs after matrix diamond, and microdiamond aggregates preserved in garnet identified by Raman spectroscopy indicate that parts of the complex were subjected to physical conditions of ~600 °C and &gt;2.8 GPa for coesite-bearing rocks, and &gt;3.2 GPa for diamond-bearing rocks. Peak UHP eclogite-facies metamorphism took place at ca. 385 Ma, and rocks were exhumed through retrograde blueschist-facies conditions by ca. 360 Ma. Bulk analyses of 18 rocks reflect the presence of mid-oceanic-ridge basalt (MORB), oceanic-island basalt (OIB), and island-arc tholeiite (IAT) basaltic and andesitic series plus their metasomatized equivalents. To more fully constrain the petrotectonic evolution of the complex, we computed isochemical phase equilibria models for representative metabasites in the system Na2O-CaO-K2O-FeO-MgO-Al2O3-SiO2-H2O-TiO2 based on our new bulk-rock X-ray fluorescence (XRF) data. Both conventional Fe-Mg exchange thermometry and phase equilibrium modeling result in higher peak equilibrium temperatures than were previously reported for the complex. Pseudosection analysis provides minimum P-T conditions of 650–675 °C and 2.4–2.6 GPa for peak assemblages of the least retrogressed Maksyutov eclogites, whereas Fe-Mg exchange thermometry yields temperatures of 750 ± 25 °C for a pressure of 2.5 GPa. We interpret our new P-T data to reflect a thermal maximum reached by the eclogites on their initial decompression-exhumation stage, that defines a metamorphic field gradient; the relict coesite and microdiamond aggregates previously reported testify to pressure maxima that define an earlier prograde subduction zone gradient. The eclogitic Maksyutov complex marks underflow of the paleo-Asian oceanic plate and does not represent subduction of the Siberian cratonal margin.
Geological and seismic evidence for the tectonic evolution of the NE Oman continental margin and Gulf of Oman
Authors: Levell Bruce , Searle Michael , White Adrian , Kedar Lauren , Droste Henk , Van Steenwinkel Mia 
Published: August 2021

AbstractLate Cretaceous obduction of the Semail ophiolite and underlying thrust sheets of Neo-Tethyan oceanic sediments onto the submerged continental margin of Oman involved thin-skinned SW-vergent thrusting above a thick Guadalupian–Cenomanian shelf-carbonate sequence. A flexural foreland basin (Muti and Aruma Basin) developed due to the thrust loading. Newly available seismic reflection data, tied to wells in the Gulf of Oman, suggest indirectly that the trailing edge of the Semail Ophiolite is not rooted in the Gulf of Oman crust but is truncated by an ENE-dipping extensional fault parallel to the coastline. This fault is inferred to separate the Semail ophiolite to the SW from in situ oceanic Gulf of Oman crust to the NE. It forms the basin margin to a “hinterland” basin formed atop the Gulf of Oman crust, in which 5 km of Late Cretaceous deep-water mudstones accumulated together with 4 km of Miocene and younger deep-water mudstones and sandstones. Syndepositional folding included Paleocene–Eocene folds on N-S axes, and Paleocene to Oligocene growth faults with roll-over anticlines, along the basin flank. Pliocene compression formed, or tightened, box folds whose axes parallel the modern coast with local south-vergent thrusts and reversal of the growth faults. This Pliocene compression resulted in large-scale buckling of the Cenozoic section, truncated above by an intra-Pliocene unconformity. A spectacular 60-km-long, Eocene(?) to Recent, low-angle, extensional, gravitational fault, down-throws the upper basin fill to the north. The inferred basement of the hinterland basin is in situ Late Cretaceous oceanic lithosphere that is subducting northwards beneath the Makran accretionary prism.
Morphological variants of meibomian glands: correlation of meibography features with histopathology findings
Authors: Singh Swati , Naidu Gorrepati C , Vemuganti Geeta , Basu Sayan 
Published: August 2021

PurposeThis study describes the histopathological features of different morphological variants of human meibomian glands (MGs) seen on infrared imaging.MethodsTarsal plates dissected from seven cadaveric upper eyelids were imaged using infrared meibography, and then studied histopathologically using H&E, peroxisome proliferator-activated receptor gamma (PPARγ, meibocyte differentiation marker) and Ki-67 (cellular proliferation marker) antibody staining. The different morphological characteristics (varying size and shape) of MGs on meibography were correlated with histopathology findings using image analysis software.ResultsOf the total 127 glands, the morphological variants observed on meibography based on size were: normal (n=62), short (n=18), severely short (n=6) and dropout (n=12) glands, and on shape were: hooked (n=2), tortuous (n=5), overlapping (n=1), thick (n=15) and fluffy (n=6) glands. Short, hooked, tortuous and overlapping glands had similar acinar and ductal histology as seen in normal glands whereas thick, and fluffy glands had increased acinar diameter. All glands except the severely short type demonstrated normal signs of holocrine secretory activity and normal nuclear and cytoplasmic PPARγ expression. Severely short glands had nil while short glands had reduced Ki-67 proliferation index (3%±1%) as compared with normal and other variants (8%±5.2%). Gland dropout areas showed no evidence of any glandular tissue on histology.ConclusionHooked, tortuous and overlapping glands had completely normal glandular histology, whereas severely short glands showed atrophic changes with loss of meibocyte differentiation and cellular proliferation. Dropout areas showed total loss of glandular elements. Further studies are needed to validate and to explore the clinical implications of these findings.
Changing trends in ocular trauma during the COVID-19 pandemic in the USA
Authors: Halawa Omar A , Friedman David S , Roldan Ana M , Zebardast Nazlee 
Published: August 2021

Background/aimsThe COVID-19 pandemic has been associated with a decline in emergency department (ED) presentations for trauma. The purpose of this study is to compare the estimated number and characteristics of eye injuries in 2020, the year of the COVID-19 pandemic, to those in 2011–2019.MethodsA stratified probability sample of US ED-treated eye injuries was used to calculate the estimated annual number and incidence of these injuries in 2020, the year of the pandemic, and 2011–2019 (prepandemic years). Two-sample t-tests and Pearson χ2were used to assess differences in demographics and injury characteristics. For multiple comparisons, Bonferroni correction was applied.ResultsThe estimated number of ED-treated eye injuries per year was 152 957 (95% CI 132 637 to 176 153) in 2020 and 194 142 (95% CI 191 566 to 196 401) in 2011–2019. The annual incidence of ED-treated eye injuries was lower in 2020, at 46 per 100 000 population than in 2011–2019, at 62 per 100 000 per year (p<0.001). In 2020 vs 2011–2019, there was a higher incidence of ruptured globes (0.5 per 100 000 vs 0.3 per 100 000 per year, p<0.001), hyphemas (0.6 per 100 000 vs 0.4 per 100 000 per year, p<0.001), lacerations (1.0 per 100 000 in 2020 vs 0.8 per 100 000 per year, p<0.001) and orbital fractures (0.3 per 100 000 vs 0.03).ConclusionThe estimated incidence of eye injuries presenting to the ED was significantly lower in 2020 than in 2011–2019, but there was a higher estimated incidence of severe eye injuries. Changes in living and work environments due to the COVID-19 pandemic were likely associated with the differences in ocular trauma presentations observed in this study.
Effectiveness of the CoronaVac vaccine in older adults during a gamma variant associated epidemic of covid-19 in Brazil: test negative case-control study
Authors: Ranzani Otavio T , Hitchings Matt D T , Dorion Murilo , D’Agostini Tatiana Lang , de Paula Regiane Cardoso , de Paula Olivia Ferreira Pereira , Villela Edlaine Faria de Moura , Torres Mario Sergio Scaramuzzini , de Oliveira Silvano Barbosa , Schulz Wade , Almiron Maria , Said Rodrigo , de Oliveira Roberto Dias , Vieira da Silva Patricia , de Araújo Wildo Navegantes , Gorinchteyn Jean Carlo , Andrews Jason R , Cummings Derek A T , Ko Albert I , Croda Julio 
Published: August 2021

Abstract

Objective
To estimate the effectiveness of the inactivated whole virus vaccine, CoronaVac (Sinovac Biotech), against symptomatic covid-19 in the elderly population of São Paulo state, Brazil during widespread circulation of the gamma variant.

Design
Test negative case-control study.

Setting
Community testing for covid-19 in São Paulo state, Brazil.

Participants
43 774 adults aged ≥70 years who were residents of São Paulo state and underwent reverse transcription polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 from 17 January to 29 April 2021. 26 433 cases with symptomatic covid-19 and 17 622 test negative controls with covid-19 symptoms were formed into 13 283 matched sets, one case with to up to five controls, according to age, sex, self-reported race, municipality of residence, previous covid-19 status, and date of RT-PCR test (±3 days).

Intervention
Vaccination with a two dose regimen of CoronaVac.

Main outcome measures
RT-PCR confirmed symptomatic covid-19 and associated hospital admissions and deaths.

Results
Adjusted vaccine effectiveness against symptomatic covid-19 was 24.7% (95% confidence interval 14.7% to 33.4%) at 0-13 days and 46.8% (38.7% to 53.8%) at ≥14 days after the second dose. Adjusted vaccine effectiveness against hospital admissions was 55.5% (46.5% to 62.9%) and against deaths was 61.2% (48.9% to 70.5%) at ≥14 days after the second dose. Vaccine effectiveness ≥14 days after the second dose was highest for the youngest age group (70-74 years)—59.0% (43.7% to 70.2%) against symptomatic disease, 77.6% (62.5% to 86.7%) against hospital admissions, and 83.9% (59.2% to 93.7%) against deaths—and declined with increasing age.

Conclusions
Vaccination with CoronaVac was associated with a reduction in symptomatic covid-19, hospital admissions, and deaths in adults aged ≥70 years in a setting with extensive transmission of the gamma variant. Vaccine protection was, however, low until completion of the two dose regimen, and vaccine effectiveness was observe to decline with increasing age among this elderly population.
Effectiveness of intermittent preventive treatment in pregnancy with sulphadoxine-pyrimethamine (IPTp-SP) in Ghana
Authors: Dosoo David Kwame , Malm Kezia , Oppong Felix Boakye , Gyasi Richard , Oduro Abraham , Williams John , Atibilla Dorcas , Peprah Nana Yaw , Twumasi Mieks , Owusu-Agyei Seth , Greenwood Brian , Chandramohan Daniel , Asante Kwaku Poku 
Published: August 2021

IntroductionGhana adopted the revised WHO recommendation on intermittent preventive treatment in pregnancy using sulfadoxine-pyrimethamine (IPTp-SP) in 2012. This study has assessed the effectiveness and safety of this policy in Ghana.MethodsA total of 1926 pregnant women enrolled at antenatal care (ANC) clinics were assessed for birth outcomes at delivery, and placental histology results for malaria infection were obtained from 1642 participants. Association of reduced placental or peripheral malaria, anaemia and low birth weight (LBW) in women who received ≥4 IPTp-SP doses compared with 3 or ≤2 doses was determined by logistic regression analysis.ResultsAmong the 1926 participants, 5.3% (103), 19.2% (369), 33.2% (640) and 42.3% (817) of women had received ≤1, 2, 3 or ≥4 doses, respectively. There was no difference in risk of active placental malaria (PM) infection in women who received 3 doses compared with ≥4 doses (adjusted OR (aOR) 1.00, 95% CI 0.47 to 2.14). The risk of overall PM infection was 1.63 (95% CI 1.07 to 2.48) in 2 dose group and 1.06 (95% CI 0.72 to 1.57) in 3 dose group compared with ≥4 dose group. The risk of LBW was 1.55 (95% CI 0.97 to 2.47) and 1.06 (95% CI 0.68 to 1.65) for 2 and 3 dose groups, respectively, compared with the ≥4 dose group. Jaundice in babies was present in 0.16%, and 0% for women who received ≥4 doses of SP.ConclusionThere was no difference in the risk of PM, LBW or maternal anaemia among women receiving 3 doses compared with ≥4 doses. Receiving ≥3 IPTp-SP doses during pregnancy was associated with a lower risk of overall PM infection compared with 2 doses. As there are no safety concerns, monthly administration of IPTp-SP offers a more practical opportunity for pregnant women to receive ≥3 doses during pregnancy.
Sexual harassment at work within Belgian Defence: a prevalence study
Authors: Buyse Kaatje , Goorts K , Peeters D , Dhondt E , Portzky G 
Published: August 2021

IntroductionSexual harassment (SH) at work can have an impact on the general health and well-being and on the productivity of the employee. To date, the Belgian Armed Forces do not have any accurate data about SH. Therefore, this study assessed the prevalence of SH within Belgian Defence.MethodsThe prevalence of SH and staff mental well-being was investigated in a sample of 399 female soldiers. Using quantitative analysis, we measured the impact on mental well-being and the relation to demographic characteristics. Using a qualitative analysis in a subsample of eight female soldiers, we investigated barriers to reporting SH and the impact on professional performance and psychosocial well-being.ResultsThe prevalence of non-physical SH is 36.1% over the last 12 months and 64.4% over the course of a career. Physical SH has a prevalence of 16.1% and 43.4%, respectively. Rape prevalence was reported to be 1.4% over the past 12 months, 9% over the course of their career.One in three female soldiers suffer from reduced mental well-being, which was significantly associated with SH. In the interviews, female employees report an impact of SH on professional and personal performance. The willingness to report is low due to misunderstanding, disinformation and psychosocial insecurity.ConclusionHigh prevalence numbers were found suggesting an important impact on the professional performance and mental well-being of female military personnel. Organisational changes may create more willingness among victims to report incidents to the designated services.
Use of an isometric mid-thigh pull test during musculoskeletal rehabilitation: can the criterion values from the updated British Army physical employment standards be used to inform UK Defence Rehabilitation practice?
Authors: Walters Vanessa , Coppack RJ , Cassidy RP , Suffield C , Papadopoulou T , Bilzon J , Ladlow P 
Published: August 2021

IntroductionObjective outcome measures that can quantify the force generating capacity of the lower limb are required to allow clinicians to accurately measure functional status and treatment adaptations over time. The aim of this prospective observational cohort study is to: (1) evaluate the acceptability of the isometric mid-thigh pull (IMTP) test as a measure of functional strength with military personnel undergoing residential hip pain rehabilitation; (2) compare the peak force values recorded against the updated Army physical employment standards (PES) assessment criteria and (3) assess if the minimum PES required of military personnel has the potential to inform clinical decision making and return to duty criteria within UK Defence Rehabilitation.MethodsAcceptability was assessed against patient’s adherence to the testing procedures and test burden. Clinician acceptability was assessed against ease of administration and safety of test procedure. Hip pain was recorded before, immediately following and 1 hour after testing. Net peak force was recorded using portable force plates.ResultsFull patient and clinician acceptability to IMTP testing procedures were demonstrated. Minimal changes in visual analogue scale (VAS) pain scores were demonstrated between baseline values at rest and follow-up. Despite being medically downgraded and functionally compromised due to chronic hip pain, 100% of patients met the PES expected on entry to the British Army and 79% met the PES expected at the end of basic training.ConclusionThe IMTP provides rehabilitation clinicians with an objective quantifiable measure of maximum muscle strength that can be used early in the rehabilitation care pathway. Based on our finding, it is unclear if the current British Army PES can be used as a criterion standard in Defence Rehabilitation. Therefore, further research focused on generating clinically relevant patient-specific IMTP score criteria, with a larger sample of diverse diagnostic sub-groups is required.
‘‘Those who do not vaccinate don’t love themselves, or anyone else’’: a qualitative study of views and attitudes of urban pregnant women towards maternal immunisation in Panama
Authors: Simas Clarissa , Larson Heidi J , Paterson Pauline 
Published: August 2021

ObjectivesTo identify pregnant women’s views and attitudes towards maternal immunisation in Panama based on in-depth interviews and focus groups.SettingTwo main urban centres in Panama (San Miguelito and Panama City).ParticipantsFifty-six pregnant women from Panama City (n=29) and San Miguelito (n=27).MethodsIn-depth interviews and focus groups were conducted, audio-recorded, transcribed verbatim and analysed using a deductive-inductive approach.ResultsOur findings suggest that this population perceives vaccination as a key component of maternal healthcare, not an elective part of it. The pregnant women interviewed disclosed a heightened perception of vulnerability to infectious diseases. For this reason, safety and effectiveness of maternal vaccines were closely associated for many participants (a vaccine was perceived as safe if it was effective against disease). Refusal of maternal vaccination was strongly associated with parental negligence. Participants reported the participation of husbands and partners in the decision-making around their health. Most participants reported high information-seeking behaviour, particularly online; many interviewees confirmed any information obtained online with their healthcare professionals (HCPs). Vaccine recommendations from HCPs appeared to be one of the main predictors of maternal immunisations among the sample interviewed. While acceptability of maternal vaccines was high in this sample, some pregnant women expressed concerns and doubts (e.g., that maternal vaccines could cause miscarriages) which require attention. Finally, many participants reported difficulties in accessing maternal vaccination, pointing to financial and physical barriers.ConclusionsThe acceptability of maternal immunisation was high among the interviewed women. The pregnant women’s receptiveness to maternal vaccinations, even when information provided was limited, is suggestive of high levels of trust in HCPs. Even so, HCPs and health officials should remain alert to apprehensions expressed by pregnant women. Many participants reported struggles in accessing maternal vaccination, pointing to issues that merit further examination.
Casting versus flexible intramedullary nailing in displaced forearm shaft fractures in children aged 7–12 years: a study protocol for a randomised controlled trial
Authors: Grahn Petra , Sinikumpu Juha-Jaakko , Nietosvaara Yrjänä , Syvänen Johanna , Salonen Anne , Ahonen Matti , Helenius Ilkka 
Published: August 2021

IntroductionThe forearm is the most common fracture location in children, with an increasing incidence. Displaced forearm shaft fractures have traditionally been treated with closed reduction and cast immobilisation. Diaphyseal fractures in children have poor remodelling capacity. Malunion can cause permanent cosmetic and functional disability. Internal fixation with flexible intramedullary nails has gained increasing popularity, without evidence of a better outcome compared with closed reduction and cast immobilisation.Method and analysisThis is a multicentre, randomised superiority trial comparing closed reduction and cast immobilisation to flexible intramedullary nails in children aged 7–12 years with >10° of angulation and/or >10 mm of shortening in displaced both bone forearm shaft fractures (AO-paediatric classification: 22D/2.1–5.2). A total of 78 patients with minimum 2 years of expected growth left are randomised in 1:1 ratio to either treatment group. The study has a parallel non-randomised patient preference arm. Both treatments are performed under general anaesthesia. In the cast group a long arm cast is applied for 6 weeks. The flexible intramedullary nail group is immobilised in a collar and cuff sling for 4 weeks. Data are collected at baseline and at each follow-up until 1 year.Primary outcome is (1) PROMIS paediatric upper extremity and (2) forearm pronation-supination range of motion at 1-year follow-up. Secondary outcomes are Quick DASH, Paediatric Pain Questionnaire, Cosmetic Visual Analogue Scale, wrist and elbow range of motion as well as any complications and costs of treatment.We hypothesise that flexible intramedullary nailing results in a superior outcome.Ethics and disseminationWe have received ethical board approval (number: 78/1801/2020) and permissions to conduct the study from all five participating university hospitals. Informed consent is obtained from the parent(s). Results will be disseminated in peer-reviewed publications.Trial registration numberNCT04664517.
Social determinants and changes in energy drink consumption among adolescents in Norway, 2017–2019: a cross-sectional study
Authors: Kaldenbach Siri , Strand Tor A , Solvik Beate Stokke , Holten-Andersen Mads 
Published: August 2021

ObjectivesTo describe the social determinants and development in energy drink consumption among Norwegian adolescents in 2017, 2018 and 2019.DesignCross-sectional, online, annual, nationwide surveys (Ungdata).SettingResponses collected online from January 2017 to December 2019.ParticipantsLower and upper secondary school students (n=297 102) aged 12–19 years who responded in 2017, 2018 and 2019.Main outcome measuresFrequency of energy drink consumption.ResultsOver the 3-year period, 66.4% of the men and 41.8% of the women had consumed energy drink once a week or more. The proportion of female high consumers (consuming energy drink more than four times a week) increased from 3.3% to 4.9% between 2017 and 2019; for male, the increase was from 9.8% to 11.5%. In females, the proportion of high consumers increased with 24% (relative risk; CI) (1.24; 1.09 to 1.41) from 2017 to 2018 and 46% (1.46; 1.31 to 1.62) from 2017 to 2019. The corresponding increases in males were 10% (1.10; 1.01 to 1.20) from 2017 to 2018 and 12% (1.12; 1.05 to 1.19) from 2017 to 2019. Any energy drink consumption as well as high energy drink consumption were independently associated with school level, less central residency, low socioeconomic status, physical inactivity and high leisure screen time.ConclusionWe found an increase in high consumers among both boys and girls between 2017 and 2019. The observed increase in energy drink consumption among adolescents can explain some of the increased sales of energy drink in Norway.