bluuebunny/crossref_metadata_2025_split huggingface dataset:
PD-L1 expression in urothelial bladder cancer varies more among specimen types than between companion assays
Authors: de Jong Joep J. , Stoop Hans , Boormans Joost L. , van Leenders Geert J.L.H. 
Published: April 2021

AbstractUrothelial bladder cancer (UBC) patients ineligible to platinum-based chemotherapy can be treated with immune-checkpoint inhibitors (ICI) in Programmed Death Ligand 1 (PD-L1) positive cases. Although concordance exists between different PD-L1 assays, little is known on PD-L1 expression variability in matched UBC samples. We compared PD-L1 expression in whole slides of matched transurethral resections (TURBT), radical cystectomies (RC), and lymph node metastasis (LN). Immunohistochemistry using the VENTANA PD-L1 (SP263) assay was performed on 115 patients and scored positive if expression occurred in ≥25% immune cells (IC), ≥25% tumour cells (TC), or both. PD-L1 was positive in 42.7% TURBT, 39.8% RC, and 27.3% LN specimens. Concordance was moderate (κ=0.52; P<0.001) between TURBT and RC, and fair between LN and TURBT (κ=0.31; P=0.048) or RC (κ=0.25; P=0.075). Comparison with the VENTANA PD-L1 (SP142) assay which had been performed previously on the same cohort showed moderate to substantial inter-assay agreement (κ=0.42–0.66). Although TC staining is not part of the SP142 scoring algorithm, discordant PD-L1 assay outcome could be attributed to SP263 TC≥25% staining in only 41% of cases. These results show that PD-L1 expression variability between matched specimens is higher than that between individual assays. Optimal specimen determination for PD-L1 testing needs to be addressed in future studies.
Preselection of a sorption model based on a column test: the algorithm and an example of its application
Authors: Marciniak Marek , Okońska Monika , Kaczmarek Mariusz 
Published: April 2021

AbstractIn order to describe the contamination of saturated porous media, it is necessary to find an appropriate mathematical model that includes processes occurring in aquifers, such as advection, dispersion, diffusion, and various kinds of sorption. The identification of parameters of those processes is possible through laboratory column experiments, which result in records of breakthrough curves for a conservative tracer and a reactive tracer. An algorithm leading to the preliminary selection of the mathematical model that best describes transport processes of the reactive tracer in the experimental column is proposed in this article. A study published previously presented a sensitivity analysis for an arbitrarily adopted variability of the transport parameters. The analysis involved examining changes in the shape of breakthrough curves caused by the alteration of each parameter value. Specially defined indicators called descriptors were proposed to quantitatively describe the breakthrough curves. Then, formulas were proposed to determine the percentage deviations of descriptors of the breakthrough curve obtained for the reactive tracer in relation to the descriptors of the breakthrough curve of the conservative tracer. In the work described in this article, the deviations are analyzed and an algorithm is proposed that allows the preselection of the most suitable sorption model out of the five discussed simple (one-site) and six hybrid (two-site) models. The algorithm can facilitate and accelerate the interpretation of column experiments of contaminant transport in a porous medium. An example is provided to illustrate the usability of the proposed algorithm.
The role of redox system in metastasis formation
Authors: Cencioni Chiara , Comunanza Valentina , Middonti Emanuele , Vallariello Edoardo , Bussolino Federico 
Published: April 2021

AbstractThe metastatic cancer disease represents the real and urgent clinical need in oncology. Therefore, an understanding of the complex molecular mechanisms sustaining the metastatic cascade is critical to advance cancer therapies. Recent studies highlight how redox signaling influences the behavior of metastatic cancer cells, contributes to their travel in bloodstream from the primary tumor to the distant organs and conditions the progression of the micrometastases or their dormant state. Radical oxygen species not only regulate intracellular processes but participate to paracrine circuits by diffusion to nearby cells, thus assuming unpredicted roles in the communication between metastatic cancer cells, blood circulating cells, and stroma cells at site of colonization. Here, we review recent insights in the role of radical oxygen species in the metastasis formation with a special focus on extravasation at metastatic sites.
Exact linesearch limited-memory quasi-Newton methods for minimizing a quadratic function
Authors: Ek David , Forsgren Anders 
Published: April 2021

AbstractThe main focus in this paper is exact linesearch methods for minimizing a quadratic function whose Hessian is positive definite. We give a class of limited-memory quasi-Newton Hessian approximations which generate search directions parallel to those of the BFGS method, or equivalently, to those of the method of preconditioned conjugate gradients. In the setting of reduced Hessians, the class provides a dynamical framework for the construction of limited-memory quasi-Newton methods. These methods attain finite termination on quadratic optimization problems in exact arithmetic. We show performance of the methods within this framework in finite precision arithmetic by numerical simulations on sequences of related systems of linear equations, which originate from the CUTEst test collection. In addition, we give a compact representation of the Hessian approximations in the full Broyden class for the general unconstrained optimization problem. This representation consists of explicit matrices and gradients only as vector components.
Phase Transition of the Horava-Lifshitz AdS Black Holes
Authors: Du Yun-Zhi , Zhao Hui-Hua , Zhang Li-Chun 
Published: April 2021

AbstractSome ones have showed the first-order phase transition of the Horava-Lifshitz (HL) AdS black holes has unique characters from other AdS black holes. While the coexistence zone of the first-order phase transition was not exhibited. As well known the coexistence curve of a black hole carries a lot of information about black hole, which provides a powerful diagnostic of the thermodynamic properties on black hole. We study the first-order phase transition coexistence curves of the HL AdS black holes by the Maxwell’s equal-area law, and give the boundary of two-phase coexistence zone. It is very interesting that the first-order phase transition point is determined by the pressure F on the surface of the HL AdS black hole’s horizon, instead of only the pressure P (or the temperature T). This unique property distinguishes the HL AdS black hole from the other AdS black hole systems. Furthermore, this black hole system have the critical curves, and on which every point stands for a critical point.
Influence of Uniform Compression on the Temperature Dependence of the Pseudogap of Medium-Praseodymium-Doped Y1−xPrxBa2Cu3O7−δ Single Crystals
Authors: Khadzhai G. Ya. , Chroneos A. , Goulatis Ι. L. , Kamchatnaya S. N. , Chikina A. L. , Vovk N. R. , Vovk R. V. 
Published: April 2021

AbstractThe effect of high pressure on the conductivity in the basal plane of HTSC single crystals of Y0.77Pr0.23Ba2Cu3O7−δ is investigated. It has been established that the excess conductivity, Δσ(T), of these single crystals in a wide temperature range Tf < T < T* can be described by an exponential temperature dependence. The description of the excess conductivity using the relation Δσ ~ (1 − T/T*)exp(Δ*ab/T) can be interpreted in terms of the mean-field theory, where T* is represented as the temperature pseudogap opening, and the temperature dependence of the pseudogap (PG) is satisfactorily described in the framework of the BCS-BEC crossover theory. An increase in the applied pressure leads to the effect of narrowing the temperature interval for the realization of the PG-regime, thereby expanding the region of the linear dependence ρ(T) in the ab-plane.
Global modes for the reduction of flexible multibody systems
Authors: Cammarata Alessandro 
Published: April 2021

AbstractModeling a flexible multibody system employing the floating frame of reference formulation (FFRF) requires significant computational resources when the flexible components are represented through finite elements. Reducing the complexity of the governing equations of motion through component-level reduced-order models (ROM) can be an effective strategy. Usually, the assumed field of deformation is created considering local modes, such as normal, static, or attachment modes, obtained from a single component. A different approach has been proposed in Cammarata (J. Sound Vibr. 489, 115668, 2020) for planar systems only and involves a reduction based on global flexible modes of the whole mechanism. Through the use of global modes, i.e., obtained from an eigenvalue analysis performed on the linearized dynamic system around a certain configuration, it is possible to obtain a modal basis for the flexible coordinates of the multibody system. Here, the same method is extended to spatial mechanisms to verify its applicability and reliability. It is demonstrated that global modes can be used to create ROM both at the system and component levels. Studies on the complexity of the method reveal this approach can significantly reduce the calculation times and the computational effort compared to the unreduced model. Unlike the planar case, the numerical experiments reveal that the system-level approach based on global modes can suffer from slow convergence speed and low accuracy in results.
Response shift in patient-reported outcomes: definition, theory, and a revised model
Authors: Vanier Antoine , Oort Frans J. , McClimans Leah , Ow Nikki , Gulek Bernice G. , Böhnke Jan R. , Sprangers Mirjam , Sébille Véronique , Mayo Nancy ,   the Response Shift - in Sync Working Group
Published: April 2021

Abstract
Purpose
The extant response shift definitions and theoretical response shift models, while helpful, also introduce predicaments and theoretical debates continue. To address these predicaments and stimulate empirical research, we propose a more specific formal definition of response shift and a revised theoretical model.

Methods
This work is an international collaborative effort and involved a critical assessment of the literature.

Results
Three main predicaments were identified. First, the formal definitions of response shift need further specification and clarification. Second, previous models were focused on explaining change in the construct intended to be measured rather than explaining the construct at multiple time points and neglected the importance of using at least two time points to investigate response shift. Third, extant models do not explicitly distinguish the measure from the construct. Here we define response shift as an effect occurring whenever observed change (e.g., change in patient-reported outcome measures (PROM) scores) is not fully explained by target change (i.e., change in the construct intended to be measured). The revised model distinguishes the measure (e.g., PROM) from the underlying target construct (e.g., quality of life) at two time points. The major plausible paths are delineated, and the underlying assumptions of this model are explicated.

Conclusion
It is our hope that this refined definition and model are useful in the further development of response shift theory. The model with its explicit list of assumptions and hypothesized relationships lends itself for critical, empirical examination. Future studies are needed to empirically test the assumptions and hypothesized relationships.
Metabolic effects of agro-infiltration on N. benthamiana accessions
Authors: Drapal Margit , Enfissi Eugenia M. A. , Fraser Paul D. 
Published: April 2021

AbstractOver the recent years, Nicotiana benthamiana has gained great importance as a chassis for the production of high value, low volume pharmaceuticals and/or active pharmaceutical ingredients (APIs). The process involving infiltration of the N. benthamiana leaves with Agrobacterium spp, harbouring vectors with the gene of interest, facilitates transient expression. To date, little information is available on the effect of the agro-infiltration process on the metabolome of N. benthamiana, which is necessary to improve the process for large-scale, renewable manufacturing of high value compounds and medical products. Hence, the objective of the present study was to assess metabolic adaptation of N. benthamiana as a response to the presence of Agrobacterium. The present study elucidated changes of the steady-state metabolism in the agroinfiltrated leaf area, the area around the infection and the rest of the plant. Furthermore, the study discusses the phenotypic advantages of the N. benthamiana lab strain, optimised for agro-infiltration, compared to three other wild accessions. Results showed that the lab strain has a different metabolic composition and showed less alterations of the phenylpropanoid pathway and cell wall remodelling in the agroinfiltrated leaf areas, for example chlorogenic acid, cadaverine and C18:0–2-glycerol ester. In conclusion, both of these alterations present potential candidates to improve the phenotype of the N. benthamiana lab strain for a more efficient transient expression process.
Fracture Energy Measurement of Prismatic Plane and Σ2 Boundary in Cemented Carbide
Authors: Emmanuel Max , Gavalda-Diaz Oriol , Sernicola Giorgio , M’saoubi Rachid , Persson Tomas , Norgren Susanne , Marquardt Katharina , Britton T. Ben , Giuliani Finn 
Published: April 2021

AbstractThe grain boundary network of WC in WC-Co is important, as cracks often travel intergranularly. This motivates the present work, where we experimentally measure the fracture energy of Σ2 twist grain boundaries between WC crystals using a double cantilever beam opened with a wedge under displacement control in a WC-10wt%Co sample. The fracture energy of this boundary type was compared with cleaving {$$10\overline{1}0$$

10

1
¯

0

} prismatic planes in a WC single crystal. Fracture energies of 7.04 ± 0.36 Jm−2 and 3.57 ± 0.28 Jm−2 were measured for {$$10\overline{1}0$$

10

1
¯

0

} plane and Σ2 twist boundaries, respectively.
Spectral methods for nonlinear functionals and functional differential equations
Authors: Venturi Daniele , Dektor Alec 
Published: April 2021

AbstractWe present a rigorous convergence analysis for cylindrical approximations of nonlinear functionals, functional derivatives, and functional differential equations (FDEs). The purpose of this analysis is twofold: First, we prove that continuous nonlinear functionals, functional derivatives, and FDEs can be approximated uniformly on any compact subset of a real Banach space admitting a basis by high-dimensional multivariate functions and high-dimensional partial differential equations (PDEs), respectively. Second, we show that the convergence rate of such functional approximations can be exponential, depending on the regularity of the functional (in particular its Fréchet differentiability), and its domain. We also provide necessary and sufficient conditions for consistency, stability and convergence of cylindrical approximations to linear FDEs. These results open the possibility to utilize numerical techniques for high-dimensional systems such as deep neural networks and numerical tensor methods to approximate nonlinear functionals in terms of high-dimensional functions, and compute approximate solutions to FDEs by solving high-dimensional PDEs. Numerical examples are presented and discussed for prototype nonlinear functionals and for an initial value problem involving a linear FDE.
Soil salinity mapping using Landsat 8 OLI data and regression modeling in the Great Hungarian Plain
Authors: Sahbeni Ghada 
Published: April 2021

AbstractSalt's deposition in the subsoil is known as salinization. It is caused by natural processes such as mineral weathering or human-made activities such as irrigation with saline water. This environmental issue has grown more critical and is frequently occurring in the Hungarian Great Plain, adversely influencing agricultural productivity. This study aims to predict soil salinity in the Great Hungarian Plain, located in the east of Hungary, using Landsat 8 OLI data combined with four state-of-the-art regression models, i.e., Multiple Linear Regression, Partial Least Squares Regression, Ridge Regression, and Feedforward Artificial Neural Network. For this purpose, seventy-six soil samples were collected during a field survey conducted by the Research Institute for Soil Sciences and Agricultural Chemistry between the 15 of September and the 15 of October, 2016. We used the min–max accuracy, the root-mean-square error (RMSE), and the mean squared error (MSE) to evaluate and compare the four models' performance. The results showed that the ridge regression model performed the best in terms of prediction (MSEtraining = 0.006, MSEtest = 0.0007, RMSE = 0.081), with a min–max accuracy equal to 0.75. Hence, the application of regression modeling on spectral indices, principal component analysis, and land surface temperature derived from multispectral data is an efficient method for soil salinity assessment at local scales. The resulting map can provide an overview of salinity levels and evaluate the efficiency of land management strategies in irrigated areas. An increase in sampling density will be recommended to validate this approach on the regional scale.
Designs of borders: Security, critique, and the machines
Authors: Martin-Mazé Médéric , Perret Sarah 
Published: April 2021

AbstractOver the past 15 years, the European Commission has poured millions of euros into Research and Development in border security. This article looks at the devices that are funded under this scheme. To this end, it applies Multiple Correspondence Analysis to a database of 41 projects funded under 7th Framework Programme. This method of data visualisation unearths the deep patterns of opposition that run across the sociotechnical universe where European borders are designed and created. We identify three rationalities of power at play: territorial surveillance aimed at detecting rare events in remote areas, policing of dense human flows by sorting out the benign from the dangerous, and finally global dataveillance of cargo on the move. Instead of trends towards either the hardening of borders or their virtualisation, we, therefore, find multiple rationalities of power simultaneously redefining the modalities of control at EU borders. A second finding shows where precisely critical actors are located in this sociotechnical universe and indicates that the structure of European R&D in border security keeps irregularised migrants off their radars. This finding calls for more caution as to the possibility to effectively put critique to work within the context of EU R&D.
DETERMINING THE PLACE OF PERFORMANCE UNDER ARTICLE 7(1) OF THE BRUSSELS I RECAST
Authors: Poon Arthur 
Published: April 2021

AbstractThis article calls for a reassessment of the methodology in determining the place of contractual performance under Article 7(1) of the Brussels I Regulation Recast. The first part of the article deals with Article 7(1)(a). It argues that in light of the adoption of autonomous linking factors under Article 7(1)(b), more types of contracts presently not covered within the ambits of Article 7(1)(b) should centralise jurisdiction at the places of performance of their characteristic obligations. The second part of the article considers the way Article 7(1) operates when there are multiple places of performance under the contract. The test devised by the Court of Justice of the European Union in this regard is not only difficult to apply, but the application of the test also often does not guarantee a close connection between the claim and the court taking jurisdiction. This article argues that when a claim is made in respect of a contractual obligation to be performed in more than one Member State, Article 4 should be applied instead of Article 7(1).
Intact forests of the Hkakabo Razi Landscape are a hotspot of bat diversity in South-east Asia
Authors: Bates Paul J. J. , Soisook Pipat , Oo Sai Sein Lin , Suarez-Rubio Marcela , Pimsai Awatsaya , Dejtaradol Ariya , Renner Swen C. 
Published: April 2021

AbstractThe Hkakabo Razi Landscape, in northern Kachin, Myanmar, is one of the largest remaining tracts of intact forest in South-east Asia. In 2016, we undertook a survey in its southern margins to assess bat diversity, distribution and ecology and evaluate the importance of the area for global bat conservation. Two collecting trips had taken place in the area in 1931 and 1933, with four bat species reported. We recorded 35 species, 18 of which are new for Kachin. One species, Murina hkakaboraziensis, was new to science and three, Megaerops niphanae, Phoniscus jagorii, Murina pluvialis, were new records for Myanmar. Our findings indicate high bat diversity in Hkakabo Razi; although it comprises only 1.7% of Myanmar's land area, it is home to 33.6% of its known bat species. This emphasizes Hkakabo Razi's importance for conserving increasingly threatened, forest-interior bats, especially in the families Kerivoulinae and Murininae. There is also a high diversity of other mammals and birds within the Hkakabo Razi Landscape, which supports its nomination as a World Heritage Site.
Money, Knowledge and Power
Authors: Barnard C. R. , Billing J. , Brotherston D. , Jeffery T. , Mansell P. , Wright J. 
Published: April 2021

Abstract
Financial literacy is a core life skill for participating in modern society. But how many of us have been educated about money; the importance of budgeting and saving for a rainy day; how bank accounts and debt work and when it makes sense to save for a pension? Our brief research to date indicates a shockingly low level of financial literacy in the general population. And, it does not look like this will get better soon; regarding improving financial literacy, the Financial Services Authority stated in 2003 that “Never has the need been so great or so urgent”. And yet many children will go through school without an hour spent studying financial literacy. Furthermore, efforts to improve financial literacy at older ages are either non-existent or piecemeal at best.
The consequences of poor financial literacy are especially damaging for vulnerable people. Vulnerable groups of people are most at risk of making poor financial decisions throughout their lives, which has negative consequences for saving, home ownership, debt levels, retirement and financial inclusion. In this paper, we consider various mechanisms to protect such financial customers, whilst recognising that improving financial literacy is not a silver bullet to improve customer outcomes from financial products.
Financial literacy cannot be brought to a point where the public can understand many financial products without support and advice. But surely, awareness of basic financial literacy principles can be raised, including the most important: when to seek support and advice before undertaking important financial decisions. The paper suggests some key principles for financial literacy and will also consider methods and tools to allow the public to access much-needed support and advice.