bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lymphoid interstitial pneumonitis in a newly diagnosed late presenter of human immunodeficiency virus infection: a case report
Authors: Petrakis V. , Panagopoulos P. , Ntolios P. , Chrysafis I. , Georgaraki M. , Papazoglou D. 
Published: February 2021

Abstract
Background
An increase has been described throughout the years in the frequency of various uncommon diseases in people living with human immunodeficiency virus (HIV). Particularly late presenters are associated with a significant risk not only for acquired immune deficiency syndrome (AIDS)-defining conditions but also for non AIDS-defining diseases which aggravate the prognosis of patients. Lymphoid interstitial pneumonitis (LIP) is one of these conditions described more often after the onset of HIV epidemic. LIP is a benign polyclonal lymphoproliferative disorder of the lung with not well characterized clinical and radiographic findings.

Case presentation
We report the diagnostic approach and clinical progress of a newly diagnosed late presenter of HIV infection with respiratory problems in our HIV unit. The findings of computed tomography indicated the diagnosis of HIV-associated LIP, although this condition is mainly described in a normal range of CD4 cell count.

Conclusion
This case presentation highlights the importance of timely diagnosis and initiation of antiretroviral therapy. The increase of CD4 cell count and viral suppression may improve the symptoms of LIP.
Chemotherapy-induced myasthenic crisis in thymoma treated with primary chemotherapy with curative intent on mechanical ventilation: a case report and review of the literature
Authors: Patelli Giorgio , Bencardino Katia , Tosi Federica , Pugliano Mariateresa , Lanzani Francesca , Innocenti Alessandro , Rinaldo Alessandro , Mauri Gianluca , Cerea Giulio , Sartore-Bianchi Andrea , Torre Massimo , Agostoni Elio Clemente , Siena Salvatore 
Published: February 2021

AbstractBackgroundThymoma is an uncommon cancer often associated with myasthenia gravis, an autoimmune disorder of the neuromuscular junction characterized by muscular fatigability. In patients with advanced nonmetastatic thymoma, primary chemotherapy may be required to induce tumor shrinkage and to achieve radical resection. Cancer chemotherapy has been anecdotally reported as a trigger factor for worsening of myasthenia gravis in thymic epithelial cancers. The study of uncommon cases of chemotherapy-related myasthenic crisis is warranted to gain knowledge of clinical situations requiring intensive care support in the case of life-threatening respiratory failure.Case presentationWe report a case of an 18-year-old Caucasian woman with advanced Masaoka-Koga stage III type B2 thymoma and myasthenia gravis on treatment with pyridostigmine, steroids and intravenous immunoglobulins, who developed a myasthenic crisis 2 hours after initiation of cyclophosphamide/doxorubicin/cisplatin primary chemotherapy. Because of severe acute respiratory failure, emergency tracheal intubation, mechanical ventilation, and temporary (2 hours) discontinuation of chemotherapy were needed. Considering the curative intent of the multimodal therapeutic program, we elected to resume primary chemotherapy administration while the patient remained on mechanical ventilation. After 24 hours, the recovery of adequate respiratory function allowed successful weaning from respiratory support, and no further adverse events occurred. After 3 weeks, upon plasma exchange initiation with amelioration of myasthenic symptoms, a second course of chemotherapy was given, and in week 6, having documented partial tumor remission, the patient underwent radical surgery (R0) and then consolidation radiation therapy with 50.4 Gy in 28 fractions in weeks 15–20.ConclusionsThis case report, together with the only four available in a review of the literature, highlights that chemotherapy may carry the risk of myasthenic crisis in patients affected by thymoma and myasthenia gravis. To our knowledge, this is the first reported case of chemotherapy continuation on mechanical ventilation in a patient with chemotherapy-induced myasthenic crisis requiring tracheal intubation. The lesson learned from the present case is that, in selected cases of advanced thymoma, the paradoxical worsening of myasthenia gravis during chemotherapy should not be considered an absolute contraindication for the continuation of primary chemotherapy with curative intent.
Hydroxychloroquine, a successful treatment for lung disease in ABCA3 deficiency gene mutation: a case report
Authors: Shaaban Waleed , Hammoud Majeda , Abdulraheem Ali , Elsayed Yasser Yahia , Alkazemi Nawal 
Published: February 2021

Abstract
Background
Pulmonary surfactant is a complex mixture of lipids and specific proteins that stabilizes the alveoli at the end of expiration. Mutations in the gene coding for the triphosphate binding cassette transporter A3 (ABCA3), which facilitates the transfer of lipids to lamellar bodies, constitute the most frequent genetic cause of severe neonatal respiratory distress syndrome and chronic interstitial lung disease in children. Hydroxychloroquine can be used as an effective treatment for this rare severe condition.

Case presentation
We report a late preterm Bosnian baby boy (36 weeks) who suffered from a severe form of respiratory distress syndrome with poor response to intensive conventional management and whole exome sequencing revealed homozygous ABCA3 mis-sense mutation. The baby showed remarkable improvement of the respiratory condition after the initiation of Hydroxychloroquine, Azithromycin and Corticosteroids with the continuation of Hydroxychloroquine as a monotherapy till after discharge from the hospital.

Conclusion
Outcome in patients with ABCA3 mutations is variable ranging from severe irreversible respiratory failure in early infancy to chronic interstitial lung disease in childhood (ChILD) usually with the need for lung transplantation in many patients surviving this rare disorder. Hydroxychloroquine through its anti-inflammatory effects or alteration of intra-cellular metabolism may have an effect in treating cases of ABCA3 gene mutations.
A false alarm of COVID-19 pneumonia in lung cancer with anti-PD-1 related pneumonitis: a case report and review of the literature
Authors: Dai Ying , Liu Sha , Zhang Yiruo , Li Xiaoqiu , Zhao Zhiyan , Liu Pingping , Du Yingying 
Published: February 2021

Abstract
Background
Pneumonitis belongs to the fatal toxicities of anti-PD-1/PD-L1 treatments. Its diagnosis is based on immunotherapeutic histories, clinical symptoms, and the computed tomography (CT) imaging. The radiological features were typically ground-glass opacities, similar to CT presentation of 2019 Novel Coronavirus (COVID-19) pneumonia. Thus, clinicians are cautious in differential diagnosis especially in COVID-19 epidemic areas.

Case presentation
Herein, we report a 67-year-old Han Chinese male patient presenting with dyspnea and normal body temperature on the 15th day of close contact with his son, who returned from Wuhan. He was diagnosed as advanced non-small cell lung cancer and developed pneumonitis post Sintilimab injection during COIVD-19 pandemic period. The chest CT indicated peripherally subpleural lattice opacities at the inferior right lung lobe and bilateral thoracic effusion. The swab samples were taken twice within 72 hours and real-time reverse-transcription polymerase-chain-reaction (RT-PCR) results were COVID-19 negative. The patient was thereafter treated with prednisolone and antibiotics for over 2 weeks. The suspicious lesion has almost absorbed according to CT imaging, consistent with prominently falling CRP level. The anti-PD-1 related pneumonitis mixed with bacterial infection was clinically diagnosed based on the laboratory and radiological evidences and good response to the prednisolone and antibiotics.

Conclusion
The anti-PD-1 related pneumonitis and COVID-19 pneumonia possess similar clinical presentations and CT imaging features. Therefore, differential diagnosis depends on the epidemiological and immunotherapy histories, RT-PCR tests. The response to glucocorticoid is still controversial but helpful for the diagnosis.
Primary care during the transition to adult care for adolescents involved with pediatric specialty services: a scoping review protocol
Authors: Schraeder Kyleigh , Allemang Brooke , Scott Cathie , McBrien Kerry , Dimitropoulos Gina , Felske Ashley , Samuel Susan 
Published: February 2021

Abstract
Background
Of the 15–20% of youth in North America affected by a chronic health condition (e.g., type 1 diabetes, cystic fibrosis) and/or mental health or neurodevelopmental disorder (e.g., depression, eating disorder, Attention Deficit-Hyperactivity Disorder), many often require lifelong specialist healthcare services. Ongoing primary care during childhood and into young adulthood is recommended by best practice guidelines. To date, it is largely unknown if, how, and when primary care physicians (PCPs; such as family physicians) collaborate with specialists as AYAs leave pediatric-oriented services. The proposed scoping review will synthesize the available literature on the roles of PCPs for AYAs with chronic conditions leaving pediatric specialty care and identify potential benefits and challenges of maintaining PCP involvement during transition.

Methods
Arksey and O’Malley’s original scoping review framework will be utilized with guidance from Levac and colleagues and the Joanna Briggs Institute. A search of databases including MEDLINE (OVID), EMBASE, PsycINFO, and CINAHL will be conducted following the development of a strategic search strategy. Eligible studies will (i) be published in English from January 2004 onwards, (ii) focus on AYAs (ages 12–25) with a chronic condition(s) who have received specialist services during childhood, and (iii) include relevant findings about the roles of PCPs during transition to adult services. A data extraction tool will be developed and piloted on a subset of studies. Both quantitative and qualitative data will be synthesized.

Discussion
Key themes about the roles of PCPs for AYAs involved with specialist services will be identified through this review. Findings will inform the development and evaluation of a primary-care based intervention to improve transition care for AYAs with chronic conditions.
Some dynamic Hilbert-type inequalities for two variables on time scales
Authors: Abd El-Hamid H. A. , Rezk H. M. , Ahmed A. M. , AlNemer Ghada , Zakarya M. , El Saify H. A. 
Published: February 2021

AbstractIn this paper, we discuss some new Hilbert-type dynamic inequalities on time scales in two separate variables. We also deduce special cases, like some integral and their respective discrete inequalities.
New approaches for periodic wave solutions of a non-Newtonian filtration equation with variable delay
Authors: Xu Mei , Du Bo 
Published: February 2021

AbstractA type of non-Newtonian filtration equations with variable delay is considered. Using a new approach which was established by Ge and Ren in (Nonlinear Anal. 58:477–488, 2004), we obtain the existence of periodic wave solutions for the non-Newtonian filtration equations. The methods of the present paper are markedly different from the existing ones.
Contributions of the fixed point technique to solve the 2D Volterra integral equations, Riemann–Liouville fractional integrals, and Atangana–Baleanu integral operators
Authors: Hammad Hasanen A. , Aydi Hassen , Mlaiki Nabil 
Published: February 2021

AbstractIn this manuscript, some fixed point results for generalized contractive type mappings under mild conditions in the setting of double controlled metric spaces (in short, $\eta _{\gimel }^{\nu }$

η
ℷ
ν

-metric spaces) are obtained. Moreover, some related consequences dealing with a common fixed point concept and nontrivial examples to support our results are presented. Ultimately, we use the theoretical results to discuss the existence and uniqueness of solutions of 2D Volterra integral equations, Riemann–Liouville integrals and Atangana–Baleanu integral operators are given.
Multiplexed single‐cell mass cytometry reveals distinct inhibitory effects on intracellular phosphoproteins by midostaurin in combination with chemotherapy in AML cells
Authors: Rörby Emma , Adolfsson Jörgen , Hultin Erik , Gustafsson Thomas , Lotfi Kourosh , Cammenga Jörg , Jönsson Jan-Ingvar 
Published: February 2021

Abstract
Background
Fms-related tyrosine kinase 3 (FLT3) receptor serves as a prognostic marker and therapeutic target in acute myeloid leukemia (AML). Approximately one-third of AML patients carry mutation in FLT3, associated with unfavourable prognosis and high relapse rate. The multitargeted kinase inhibitor midostaurin (PKC412) in combination with standard chemotherapy (daunorubicin and cytarabine) was recently shown to increase overall survival of AML patients. For that reason, PKC412 has been approved for treatment of AML patients with FLT3-mutation. PKC412 synergizes with standard chemotherapy, but the mechanism involved is not fully understood and the risk of relapse is still highly problematic.

Methods
By utilizing the unique nature of mass cytometry for single cell multiparameter analysis, we have explored the proteomic effect and intracellular signaling response in individual leukemic cells with internal tandem duplication of FLT3 (FLT3-ITD) after midostaurin treatment in combination with daunorubicin or cytarabine.

Results
We have identified a synergistic inhibition of intracellular signaling proteins after PKC412 treatment in combination with daunorubicin. In contrast, cytarabine antagonized phosphorylation inhibition of PKC412. Moreover, we found elevated levels of FLT3 surface expression after cytarabine treatment. Interestingly, the surface localization of FLT3 receptor increased in vivo on the blast cell population of two AML patients during day 3 of induction therapy (daunorubicin; once/day from day 1–3 and cytarabine; twice/day from day 1–7). We found FLT3 receptor expression to correlate with intracellular cytarabine (AraC) response. AML cell line cultured with AraC with or without PKC412 had an antagonizing phosphorylation inhibition of pAKT (p = 0.042 and 0.0261, respectively) and pERK1/2 (0.0134 and 0.0096, respectively) in FLT3high compared to FLT3low expressing cell populations.

Conclusions
Our study provides insights into how conventional chemotherapy affects protein phosphorylation of vital signaling proteins in human leukemia cells. The results presented here support further investigation of novel strategies to treat FLT3-mutated AML patients with PKC412 in combination with chemotherapy agents and the potential development of novel treatment strategies.
Reframing the magnetotelluric phase tensor for monitoring applications: improved accuracy and precision in strike determinations
Authors: Bravo-Osuna Ana G. , Gómez-Treviño Enrique , Cortés-Arroyo Olaf J. , Delgadillo-Jauregui Nestor F. , Arellano-Castro Rocío F. 
Published: February 2021

AbstractThe magnetotelluric method is increasingly being used to monitor electrical resistivity changes in the subsurface. One of the preferred parameters derived from the surface impedance is the strike direction, which is very sensitive to changes in the direction of the subsurface electrical current flow. The preferred method for estimating the strike changes is that provided by the phase tensor because it is immune to galvanic distortions. However, it is also a fact that the associated analytic formula is unstable for noisy data, something that limits its applicability for monitoring purposes, because in general this involves comparison of two or more very similar datasets. One of the issues is that the noise complicates the distribution of estimates between the four quadrants. This can be handled by sending all values to the same quadrant by adding or subtracting the appropriate amount. This is justified by showing that the analytic formula is also a least squares solution. This is equivalent to define penalty functions for the matrix of eigenvalues and then select the minima numerically. Contrary to the analytic formula, this numerical approach can be generalized to compute strikes using windows of any number of periods, thus providing tradeoffs between variance and resolution. The performance of the proposed approach is illustrated by its application to synthetic data and to real data from a monitoring array in the Cerro Prieto geothermal field, México.
Attenuation contrast in mantle wedge across the volcanic front of northeastern Japan that controls propagations of high-frequency S-wave later phases
Authors: Shiina Takahiro , Katsumata Kei , Yomogida Kiyoshi , Kato Aitaro 
Published: February 2021

AbstractDistinct later phases of waves with rich high-frequency (> 8 Hz) components were observed for intraslab earthquakes that occurred at intermediate depths, particularly at depths exceeding 100 km, in the northeastern (NE) Japan subduction zone. These high-frequency later phases (HFLPs) showed anomalously large peak-amplitude delays, up to ~ 50 s after direct S-wave arrivals at stations in the backarc region. Using a source-scanning algorithm, we investigated the locations of passing points affecting the propagation of HFLPs. The passing points were estimated to be in the forearc region in the entire NE Japan, indicating that HFLPs are scattered waves that pass through the forearc region. The propagating HFLPs seem to bypass the backarc mantle wedge, as a consequence of the distinct attenuation contrast in the mantle wedge across the volcanic front in NE Japan. These HFLP observations suggest that the high-attenuation zone in the backarc mantle wedge controls propagations of the high-frequency waves of intraslab earthquakes, in addition to the scatterers possibly locate in the forearc region.
Postoperative incidence of seizure and cerebral infarction in pediatric patients with epileptic type moyamoya disease: a meta-analysis of single rate
Authors: Liu Jingjing , Xu Qinlan , Niu Hongchuan , Wang Rong , Ye Xun , Liu Xianzeng 
Published: February 2021

Abstract
Background
Surgery is a conventional mature treatment for moyamoya disease (MMD). However, whether surgery is also an effective therapy for epileptic type MMD has seldom been investigated systematically. The study aims to summarize the pooled postoperative incidence of seizure and cerebral infarction in pediatric patients with epileptic type moyamoya disease.

Method
The study was a systematic review and critical appraisal with a meta-analysis of cohort studies, both prospective and retrospective. Studies were identified by a computerized search of PubMed, Embase, Web of Science, Wanfang, and CNKI databases. In a literature search, a total of 7 cohort studies were identified. The I2statistic was used to quantify heterogeneity. A fixed-effect model was used to synthesize the results. The linear regression test of funnel plot asymmetry was used to estimate the potential publication bias.

Results
The pooled estimated postoperative incidence of seizure in pediatric patients with epileptic type moyamoya disease was 23.44%. The pooled estimated postoperative incidence of cerebral infarction in pediatric patients with epileptic type moyamoya disease was 9.12%. Low substantial heterogeneity and potential publication bias were present.

Conclusions
Evidence from this study suggests that the postoperative incidence of seizure and cerebral infarction is relatively low. Surgery is an effective and secure therapy for pediatric patients with epileptic type moyamoya disease.
Human keratinocyte-derived extracellular vesicles activate the MAPKinase pathway and promote cell migration and proliferation in vitro
Authors: Glady Azela , Vandebroek Arno , Yasui Masato 
Published: February 2021

Abstract
Background
Wound healing is a complex biological process and complete skin regeneration is still a critical challenge. Extracellular vesicles (EVs) play essential roles in cell communication and cell regeneration, and recent studies have suggested that EVs may contribute to wound healing, though the molecular mechanisms behind this contribution remain unclear. For these reasons, we decided to use EVs isolated from human keratinocytes (HaCaT) in vitro to determine the potential mechanism of action of EV-derived wound healing.

Method
Scratch assays were used to determine cell migration and proliferation. Scratched cells were exposed to EVs in multiple conditions to determine how they affect wound healing. Statistical analysis between groups was carried out to using Student’s two-sided t test. A p value of <  0.05 was considered statistically significant.

Result
We found that proteomic analysis of purified EVs shows enrichment of proteins associated with cell communication and signal transduction, such as MAPK pathways, and keratinocyte and fibroblast cultures exposed to EVs had higher levels of proliferation, migration, and ERK1/2 and P38 activation. Moreover, we found that treatment with specific ERK1/2 and P38 signaling inhibitors PD98059 and SB239063 impaired EV-mediated cell migration, which suggests that ERK1/2 and P38 signaling is essential for EV-induced wound healing.

Conclusion
HaCaT cell-derived EVs accelerate the migration and proliferation of human keratinocytes and fibroblasts and may promote wound healing via the activation of MAPKinase pathways. These findings may be key in developing new methods to treat wounds and accelerate wound healing in the future.
Cervix Cancer in Sub-Saharan Africa: An Assessment of Cervical Cancer Management
Authors: Burt Lindsay M. , McCormak Mary , Lecuru Fabrice , Kanyike Daniel M. , Bvochora-Nsingo Memory , Ndlovu Ntokozo , Scott Aba A. , Anorlu Rose I. , Sharma Vinay , Plante Marie , Nyongesa Catherine , Tigeneh Wondemagegnehu , Fakie Nazia , Suneja Gita , Gaffney David K. 
Published: February 2021

PURPOSE Underdeveloped nations carry the burden of most cervical cancer, yet access to adequate treatment can be challenging. This report assesses the current management of cervical cancer in sub-Saharan Africa to better understand the needs of underdeveloped nations in managing cervical cancer. METHODS A pre- and postsurvey was sent to all centers participating in the Cervical Cancer Research Network's 4th annual symposium. The pre- and postsurvey evaluated human papillomavirus and HIV screening, resources available for workup and/or treatment, treatment logistics, outcomes, and enrollment on clinical trials. Descriptive analyses were performed on survey responses. RESULTS Twenty-nine centers from 12 sub-Saharan countries saw approximately 300 new cases of cervical cancer yearly. Of the countries surveyed, 55% of countries had a human papillomavirus vaccination program and 30% (range, 0%-65%) of women in each region were estimated to have participated in a cervical cancer screening program. In the workup of patients, 43% of centers had the ability to obtain a positron emission tomography and computed tomography scan and 79% had magnetic resonance imaging capabilities. When performing surgery, 88% of those centers had a surgeon with an expertise in performing oncological surgeries. Radiation therapy was available at 96% of the centers surveyed, and chemotherapy was available in 86% of centers. Clinical trials were open at 4% of centers. CONCLUSION There have been significant advancements being made in screening, workup, and management of patients with cervical cancer in sub-Saharan Africa; yet, improvement is still needed. Enrollment in clinical trials remains a struggle. Participants would like to enroll patients on clinical trials with Cervical Cancer Research Network's continuous support.