bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective intra-individual blinded comparison of [18F]PSMA-1007 and [68Ga]Ga-PSMA-11 PET/CT imaging in patients with confirmed prostate cancer
Authors: Pattison David A , Debowski Maciej , Gulhane Brook , Arnfield Evyn G. , Pelecanos Anita M. , Garcia Peter L. , Latter Melissa J. , Lin Charles Y. , Roberts Matthew J. , Ramsay Stuart C. , Thomas Paul A. 
Published: April 2021

Abstract
Introduction[18F]PSMA-1007 has potential advantages over [68Ga]Ga-PSMA-11, although limited prospective data evaluating diagnostic performance exist. The aims of this study are to describe the concordance of [18FPSMA-1007 and [68Ga]Ga-PSMA-11 for TNM with American Joint Committee on Cancer (AJCC) prognostic stage, and assess differences in tracer uptake.MethodsFifty men (mean age 71.8) were imaged with [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 < 4 weeks apart. Images were independently reported according to TNM by two experienced nuclear medicine specialists blinded to the other scan and prior imaging. Discordant results were resolved by a third independent nuclear medicine specialist. Quantitative analysis of lesion uptake and physiologic tissue for each tracer was performed by one experienced reader.ResultsScan indications were initial staging (n = 12), biochemical recurrence (n = 27) and metastatic disease evaluation (n = 11). Most patients had ISUP grade group 3 or higher. Median PSA value was 2.7 ng/ml (IQR 0.7–12.0) and a minority of patients (28%) were currently treated with androgen deprivation therapy. [18F]PSMA-1007 uptake was significantly higher than [68Ga]Ga-PSMA-11 in local recurrence, nodal and distant metastases, and most physiologic sites except for urinary bladder which was significantly lower. [18F]PSMA-1007 upstaged local prostate staging in 5/17 patients, local recurrence in 3/33 patients, regional nodal disease in 3/50 patients and 1 distant metastasis (bladder). [68Ga]Ga-PSMA-11 upstaged regional nodal disease in 1/50 patients and distant metastasis in one patient (right adrenal). Overall AJCC prognostic stage was concordant in 46/50 (92%) patients, with two patients upstaged for both [18F]PSMA-1007 and [68Ga]Ga-PSMA-11. [18F]PSMA-1007 had more equivocal results (one regional node; six equivocal bone lesions, one of which was subsequently confirmed metastatic) than [68Ga]Ga-PSMA-11 (one equivocal local recurrence).ConclusionOverall AJCC prognostic stage was similar (92%) between [18F]PSMA-1007 and [68Ga]Ga-PSMA-11. [18F]PSMA-1007 demonstrates higher uptake within involved nodes and distant metastases, and most physiologic sites except urinary bladder which aided [18F]PSMA-1007 local staging of the prostate primary / local recurrence and regional nodal disease adjacent ureters. However [18F]PSMA-1007 liver uptake obscured a solitary right adrenal metastasis, and more equivocal bone lesions were identified.
Comprehensive analysis of mutations and clonal evolution patterns in a cohort of patients with cytogenetically normal acute myeloid leukemia
Authors: Yusoff Yuslina Mat , Ahid Fadly , Seman Zahidah Abu , Abdullah Julia , Kamaluddin Nor Rizan , Esa Ezalia , Zakaria Zubaidah 
Published: April 2021

Abstract
Background

Relapsed acute myeloid leukemia (AML) is associated with the acquisition of additional somatic mutations which are thought to drive phenotypic adaptability driving clonal selection during treatment and evolution of leukemic clones. We performed high throughput exome sequencing of matched presentation and relapsed samples from 6 cytogenetically normal AML (CN-AML) patients treated with standard remission induction chemotherapy in order to investigate the mutational landscape of CN-AML and clonal evolution during AML treatment.
Result

A total of 24 and 32 somatic variants were identified in presentation and relapse samples respectively with an average of 4.0 variants per patient at presentation and 5.3 variants per patient at relapse, with SNVs were more frequent than indels at both disease stages. All patients have somatic variants in at least one gene that frequently mutated in AML at both disease presentation and relapse, with most of these variants are classic AML and recurrent hotspot mutations including NPM1 p.W288fs, FLT3-ITD, NRAS p.G12D and IDH2 p.R140Q. In addition, we found two clonal evolution patterns of relapse: (1) a leukemic clone at disease presentation acquires additional mutations and evolves into the relapse clone after the chemotherapy; (2) a leukemic clone at disease presentation persists at relapse without the addition of novel somatic mutations.
Conclusion

The findings from this study suggest that the relapse-initiating clones may pre-exist before therapy, which harbor or acquire mutations that confer selective advantage during chemotherapy, resulting in clonal expansion and eventually leading to relapse.
Ultra-high bandwidth fiber-optic data transmission with a single chip source
Authors: Tan Mengxi , Xu Xingyuan , Moss David 
Published: April 2021

Abstract
We report world record high data transmission over standard optical fiber from a single optical source. We achieve a line rate of 44.2 Terabits per second (Tb/s) employing only the C-band at 1550nm, resulting in a spectral efficiency of 10.4 bits/s/Hz. We use a new and powerful class of micro-comb called soliton crystals that exhibit robust operation and stable generation as well as a high intrinsic efficiency that, together with an extremely low spacing of 48.9 GHz enables a very high coherent data modulation format of 64 QAM. We achieve error free transmission across 75 km of standard optical fiber in the lab and over a field trial with a metropolitan optical fiber network. This work demonstrates the ability of optical micro-combs to exceed other approaches in performance for the most demanding practical optical communications applications.
Vulnerability Modellers Toolkit, An Open-source Platform for Vulnerability Analysis
Authors: Martins Luis , Silva Vitor , Crowley Helen , Cavalieri Francesco 
Published: April 2021

Abstract
Vulnerability functions describe the expected loss for a given ground shaking intensity level and are an essential component in probabilistic seismic risk assessment. This manuscript presents a novel open-source platform for the derivation of analytical fragility and vulnerability models, covering state-of-the-art methodologies, and addressing critical issues in vulnerability modelling such as uncertainty propagation, validation/verification of results and sufficiency/efficiency of intensity measure types. This framework is divided into six modules designed to guide users through the different stages of analytical vulnerability modelling from the selection of ground motion records to the validation and verification of the models. The platform was implemented in the Python programming language and it is freely accessible through a public GitHub repository. A graphical user interface is included with the toolkit and is intended to be a general-purpose method for modellers to interact with the VMTK. Experienced users are encouraged to use Python’s scripting capabilities to explore all the features of the VMTK source code and to contribute to future releases of the toolkit.
Feeling matters: Perceived Social Support Moderate the Relationship between Personal Relative Deprivation and Depressive Symptoms
Authors: Zhao Sibo , Peng Li 
Published: April 2021

Abstract
Background Little research describes the mechanisms underlying depressive symptoms and personal relative deprivation in Chinese populations. Methods In this study, the respondents were (N = 938) residents of Beijing (17-59 years old) and robust multiple linear regressions were used to assess the main relationship between relative deprivation and depressive symptoms and social support as a potential moderator for that relationship. Results Individuals who reported higher personal relative deprivation had greater depressive symptoms than those who reported lower personal relative deprivation. Perceived social support buffered the relationship between depressive symptoms and personal relative deprivation. Conclusions The findings of this current study demonstrate the importance of relative deprivation for psychological strain and income in explaining how socioeconomic indices correlate with depressive symptoms. They also demonstrate the need to acknowledge the interaction of perceived social support and personal relative deprivation for influencing depression.
BMI Trajectory in Childhood Is Associated With Asthma Incidence at Young Adulthood Mediated by DNA Methylation
Authors: Patel Rutu , Zhang Hongmei , Karmaus Wilfried , Ewart Susan , Relton Caroline , Ring Susan , Arshad S. Hasan , Holloway John W 
Published: April 2021

Abstract
Purpose: Body mass index (BMI) is associated with asthma but associations of BMI temporal patterns with asthma incidence are unclear. Previous studies suggest that DNA methylation (DNAm) is associated with asthma status and variation in DNAm is a consequence of BMI changes. This study assessed the direct and indirect (via DNAm) effects of BMI trajectories in childhood on asthma incidence at young adulthood. Methods: Data from the Isle of Wight (IoW) birth cohort were included in the analyses. Group-based trajectory modelling was applied to infer latent BMI trajectories from ages 1 to 10 years. An R package, ttscreening, was applied to identify differentially methylated CpGs at age 10 years associated with BMI trajectories, stratified for sex. Logistic regressions were used to further exclude CpGs with DNAm at age 10 years not associated with asthma incidence at 18 years. CpGs discovered via path analyses that mediated the association of BMI trajectories with asthma incidence in the IoW cohort were further tested in an independent cohort, the Avon Longitudinal Study of Children and Parents (ALSPAC).Results: Two BMI trajectories (high vs. normal) were identified. Of the 442,474 CpG sites, DNAm at 159 CpGs in males and 212 in females were potentially associated with BMI trajectories. Assessment of their association with asthma incidence identified 9 CpGs in males and 6 CpGs in females. DNAm at 4 of these 15 CpGs showed statistically significant mediation effects (p-value<0.05). At two of the 4 CpGs (cg23632109 and cg10817500), DNAm completely mediated the association (i.e., only statistically significant indirect effects were identified). In the ALSPAC cohort, at all four CpGs, the same direction of mediating effects were observed as those found in the IoW cohort, although statistically insignificant.Conclusion: The association of BMI trajectory in childhood with asthma incidence at young adulthood is possibly mediated by DNAm.
Protecting Security-Sensitive Data Using Program Transformation and Trusted Execution Environment
Authors: Faree Anter Abdu Alhag Ali , Wang Yongzhi 
Published: April 2021

Abstract
Cloud computing allows clients to upload their sensitive data to the public cloud and perform sensitive computations in those untrusted areas, which drives to possible violations of the confidentiality of client sensitive data. Utilizing Trusted Execution Environments (TEEs) to protect data confidentiality from other software is an effective solution. TEE is supported by different platforms, such as Intel’s Software Guard Extension (SGX). SGX provides a TEE, called an enclave, which can be used to protect the integrity of the code and the confidentiality of data. Some efforts have proposed different solutions in order to isolate the execution of security-sensitive code from the rest of the application. Unlike our previous work, CFHider, a hardware-assisted method that aimed to protect only the confidentiality of control flow of applications, in this study, we develop a new approach for partitioning applications into security-sensitive code to be run in the trusted execution setting and cleartext code to be run in the public cloud setting. Our approach leverages program transformation and TEE to hide security-sensitive data of the code. We describe our proposed solution by combining the partitioning technique, program transformation, and TEEs to protect the execution of security-sensitive data of applications. Some former works have shown that most applications can run in their entirety inside trusted areas such as SGX enclaves, and that leads to a large Trusted Computing Base (TCB). Instead, we analyze three case studies, in which we partition real Java applications and employ the SGX enclave to protect the execution of sensitive statements, therefore reducing the TCB. We also showed the advantages of the proposed solution and demonstrated how the confidentiality of security-sensitive data is protected.
Efficacy of repetitive transcranial magnetic stimulation (rTMS) for reducing consumption in patients with alcohol use disorders (ALCOSTIM): study protocol for a randomized controlled trial
Authors: Petit Benjamin , Soudry-Faure Agnès , Jeanjean Ludovic , Lalanne Laurence , Foucher Jack , Carpentier Maud , Jonval Lysiane , Allard Coralie , Ravier Mathilde , Mohamed Amine Ben , Meille Vincent , Trojak Benoit 
Published: April 2021

Abstract
Background: The number of people with an alcohol use disorder (AUD) was recently estimated to be 63.5 million worldwide. The global burden of disease and injury attributable to alcohol is considerable: about 3 million deaths, namely one in 20, were caused by alcohol in 2015. At the same time, AUD remains seriously undertreated.In this context, alternative or adjunctive therapies such as brain stimulation could play an important role. The early results of studies using repetitive transcranial magnetic stimulation (rTMS) suggest that stimulations delivered to the dorsolateral prefrontal cortex signiﬁcantly reduce cravings and improve decision-making processes in various addictive disorders. We therefore hypothesize that rTMS could lead to a decrease in alcohol consumption in patients with AUD.Methods/design: We report the protocol of a randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the efficacy of rTMS on alcohol reduction in individuals diagnosed with AUD. The study will be conducted in 2 centers in France. Altogether, 144 subjects older than 18 years and diagnosed with AUD will be randomized to receive 5 consecutive twice-daily sessions of either active or sham rTMS (10 Hz over the right DLPFC, 2000 pulses per day). The main outcomes of the study will be changes in alcohol consumption within the 4 weeks after the rTMS sessions. Secondary outcome measures will include changes in alcohol consumption within the 24 weeks, alcohol cravings, clinical and biological improvements, effects on mood and quality of life, as well as cognitive and safety assessments, and, for smokers, an assessment of the effects of rTMS on tobacco consumption.Discussion: Several studies have observed a beneficial effect of rTMS on substance use disorders by reducing craving, impulsivity and risk-taking behavior, and suggest that rTMS may be a promising treatment in addiction. However, to date, no studies have included sufficiently large samples and sufficient follow-up to confirm this hypothesis. The results from this large randomized controlled trial will give a better overview of the therapeutic potential of rTMS in AUD. Trial registrationClinicalTrials.gov, NCT04773691, registered February 26 2021https://clinicaltrials.gov/ct2/show/NCT04773691?term=trojak&draw=2&rank=5
The Efficacy of Famotidine in improvement of outcomes in Hospitalized COVID-19 Patients: A phase III randomised clinical trial
Authors: Samimagham Hamid Reza , Azad Mehdi Hassani , Haddad Maryam , Arabi Mohsen , Hooshyar Dariush , KazemiJahromi Mitra 
Published: April 2021

Abstract
IntroductionAs the first randomized clinical trial, this study evaluated the effect of Famotidine on the improvement of outcomes of hospitalized patients with COVID-19.MethodThis phase III randomized clinical trial was designed with two parallel arms, placebo-controlled, single-blind, and concealed allocation, and recruited 20 patients. Oral Famotidine 160 mg four times a day was given to patients until the discharge day or for a maximum of 14 days. Patients’ temperature, respiration rate, oxygen saturation, lung infiltration, lactate dehydrogenase (LDH) level and complete blood count (CBC) were measured at the baseline (before the intervention) and on day 14 after the intervention or on discharge day. Length of stay in the hospital and length of stay in the ICU were also measured as secondary outcomes of the study.ResultsThe results showed a significant decrease in LDH (P = 0.01), mean WBC (P = 0.04) and length of stay (P = 0.04) of patients with COVID-19 in the group treated with Famotidine compared to the control group. There was also a significant increase in oxygen saturation (P = 0.01) in the group treated with Famotidine compared to the control group. Cough improvement was also higher in the oral Famotidine group compared to the control group (P = 0.02).ConclusionThis was the first clinical trial on the effect of Famotidine on the improvement of hospitalized COVID-19 patients, which indicated that high-dose Famotidine improves patients’ clinical signs and reduces the severity of the disease and duration of hospitalization.
Holographic Transmitarray Antenna with linear Polarization in X band
Authors: Salehi Mahdi , Oraizi Homayoon 
Published: April 2021

Abstract
In this paper, we present the design and demonstration of transmitarray antennas (TAs) based on the holographic technique for the first time. According to the holographic theory, the amplitudes and phases of electromagnetic waves can be recorded on a surface, and then they can be reconstructed independently. This concept is used to design single-beam and multi-beam linearly polarized holographic TAs without using any iterative optimization algorithms. Initially, a transmission impedance surface is analyzed and compared with the reflection one. Then, interferograms associated with the scalar admittance distribution are defined according to the number and direction of the radiation beams. After that, a transmission metasurface of dimensions equal to 0.26λ0 is hired to design holographic TAs at 12 GHz. Several examples are provided to support the method. In the end, a linearly polarized circular aperture wideband holographic transmitarray antenna with a radius of 13.3 cm has been manufactured and tested. The antenna achieves 12.5% (11.4-12.9 GHz) 1-dB gain bandwidth and 23.8 dB maximum gain, leading to 21.46% aperture efficiency.
PMT-Gesetz: Wichtige Bestimmungen sind weder verfassungs- noch EMRK-konform
Authors: Mohler Markus 
Published: April 2021

In einem ersten Beitrag wurde festgestellt, dass dem Bund für den Erlass der BWIS-Novelle im Rahmen des PMT-Gesetzes die verfassungsmässige Gesetzgebungskompetenz fehlt. In diesem Beitrag wird dargelegt, dass die Umschreibung «terroristische Aktivität» und damit «terroristischer Gefährder» nach Art. 23e BWIS in Bezug auf die Normbestimmtheit weder der Bundesverfassung noch der EMRK entspricht und mit anderen völkerrechtlichen Definitionen ebenso wenig übereinstimmt. Die Rechtsstaatlichkeitsanforderungen für grundrechtsbeschränkende Eingriffe werden nicht erfüllt.
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Dans une première contribution il a été constaté que la compétence législative constitutionnelle échappe à la Confédération pour promulguer la modification de la LMSI dans le cadre de la loi sur le MPT. Il sera démontré ci-après que les définitions de « l’activité terroriste » et celle de « terroriste potentiel » selon l’art. 23e LMSI ne correspondent ni à la définition de la Constitution fédérale ni à celle de la CEDH et qu’elles ne sont pas davantage conformes aux autres définitions du droit international. Les exigences relatives à l’État de droit, nécessaires pour autoriser les interventions qui restreignent les droits fondamentaux, ne sont pas remplies.
Comparison of the SARS-CoV-2-inactivating activities of the differently manufactured hypochlorous acid water products with various pH
Authors: Takeda Yohei , Matsuda Sachiko , Jamsransuren Dulamjav , Ogawa Haruko 
Published: April 2021

Abstract
The use of effective disinfectants is a key method of controlling the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hypochlorous acid water (HAW) has a broad spectrum of virucidal activities. We previously reported that acidic electrolyzed water, one of the HAW products, had potent SARS-CoV-2-inactivating activity and showed promise as a disinfectant. However, different manufacturing methods have produced several HAW products with various pH values. Here, we compared the SARS-CoV-2-inactivating activities of various HAW products. At sufficiently high volume and residual chlorine concentration (RCC), the HAW products inactivated SARS-CoV-2 efficiently regardless of pH or manufacturing method. However, although HAW products at pH 5.0–6.4 maintained high RCC and sustained virucidal activity for 21 days, the RCC rapidly decreased in HAW products at pH ≤ 3.0. Our results may guide in choosing appropriate HAW products for different usage situations.
In-silico Studies and Wet-Lab Validation of Camptothecin Derivatives for Anti-Cancer Activity Against Liver (HepG2) and Lung (A549) Cancer Cell Lines
Authors: Kalani Komal , Yadav Dharmendra K. , Alam Sarfaraz , Khan Feroz , Kashyap Mahendra P. , Srivastava Santosh K. , Pant Aditya B. 
Published: April 2021

Bcakground:
In the present study, we have explored the utility of QSAR modelling, in
silico ADMET, docking, chemical semi-synthesis, and in vitro evaluation studies for the identification
of active camptothecin (CPT) derivatives against cancer-targeting human liver (HepG2) and
lung (A549) cancer cell lines.

Methods:
Two QSAR models were developed as screenings tools using the multiple linear regression
(MLR) method followed by ADMET and docking studies. The regression coefficient (r2) and
cross-validation regression coefficients (rCV2T) of the QSAR model for the HepG2 cell line was
0.95 and 0.90, respectively, and for the A549 cell line, it was 0.93 and 0.81, respectively.

Results:
In silico studies show that CPT derivatives (CPT-1 and CPT-6) possess drug-like properties.
Docking performed on DNA Topoisomerase-I showed significant binding affinity. Finally, predicted
active derivatives were chemically semi synthesized, spectroscopically characterized, and
evaluated in-vitro for cytotoxic/anticancer activity against HepG2 and A549 cell lines.

Conclusion:
The experimental results are consistent with the predicted results. These findings may
be of immense importance in the anticancer drug development from an inexpensive and widely
available natural product, camptothecin.
Outcome of a HIV Positive Patient Infected with COVID-19 After an Autologous Bone Marrow Transplantation: A Case Report
Authors: Mardani Masoud , Sharifi-Razavi Athena , Sheibani Shirin , Baziboroun Mana 
Published: April 2021

Background:
The World Health Organization (WHO) announced the SARS-COV-2 disease
pandemic on March 9, 2020. With the advent of this disease, another health burden was added
to about 37.9 million people in the world who are infected with HIV and are suffering from various
diseases. These people may be at serious risk of COVID-19. Information about the effects of
COVID-19 on people living with HIV, is limited.

Case Presentation:
We reported a 61-year-old man who was a known case of HIV from 6 years
ago that was being treated with HAART (highly active antiretroviral therapy). He also had a history
of Hodgkin’s lymphoma from 4 years ago who underwent autologous bone marrow transplantation
(BMT) 2 weeks before given referral to our hospital. He complained of weakness, anorexia,
and fever. RT-PCR for SARS-COV-2-RNA was positive in his nasopharyngeal and oropharyngeal
swab. He was diagnosed with COVID-19 infection and treated with atazanavir. After one week,
the patient discharged in a good general state.

Conclusion:
To the best of our knowledge, it is the first report of COVID-19 infection in an HIV
positive patient after BMT in Iran. Despite his immunodeficiency, COVID-19 disease had mild
manifestations and he had a good prognosis. We hope that our report and that of others can remain
promising to doctors and HIV patients cross fingers for COVID-19 recovery.