bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single nucleotide polymorphism in Interleukin 1 alpha gene might be involved in the Oral Herpes recurrent episodes in Brazilian Para-Athletes
Authors: Brancher João Armando , Bonetto Luana Mordask , Costa Eugenio Esteves , Von Held Rodrigo , Tavares Jhenyfer da Silva , Salgueirosa Fabiano , Scariot Rafaela , Küchler Erika Calvano , Antunes Leonardo Santos , Antunes Lívia Azeredo Alves 
Published: December 2021

The main goal of this study was to investigate if there is an association between Oral Herpes (OH) recurrent episodes and Single Nucleotide Polymorphisms (SNPs) in IL1A, IL10, and IL1RN genes in a group of Brazilian Para-athletes. This transversal study was prepared according to the STrengthening the REporting of Genetic Association Studies (STREGA) guidelines. Oral examination and DNA collection for genotyping were performed in a non-probabilistic convenience sampling composed of Brazilian para-athletes who participated in a Brazilian selective competition. Data referring to the general characterization of sample were collected through a self-reported questionnaire. Candidate genes were chosen with the UCSC Genome Browser and SNPs in IL1A gene (rs17561, rs1304037), IL10 gene (rs1800871), and IL1RN gene (rs9005) were selected and investigated in allelic, genotypic, dominant, and recessive models. Hardy-Weinberg equilibrium was evaluated in each SNP. The sample was composed of 273 para-athletes (63 (23.4%) practice swimming, 61 (22.3%) powerlifting and 145 (63.7%) athletics). OH recurrent episodes was related by 47 (17.2%) para-athletes and the presence of T allele in the rs1304037 increased chance of OH. These findings suggest that rs1304037 in IL1A gene is associated with OH recurrent episodes in para-athletes.
Contact Lens Solutions Toxicity Evaluation by the Bioluminescence Method
Authors: Levchenko Yu. S. , Stepanova L. V. 
Published: December 2021

Purpose. To study the possibility of using bioluminescence biotesting to evaluate the toxicity of contact lens care solutions.Methods. The examined solutions were tested both immediately upon unpacking (i.e. sterile) and after rinsing “Pure Vision 2” lenses in them (i.e. after use). As a test system, NADH:FMN oxidoreductase and luciferase bacterial bio enzyme system was used. It contained lyophilized highly purified ferments of EC 1.14.14.3 bacterial luciferase (0.4 mg/ml) from E.coli recombinant variant and EC 1.5.1.29 NADH:FMN oxidoreductase (Ph. leiognathi) (0.18 enzyme units). The bioluminescent testing was carried out with TriStar LB 941 microplate luminometer (Germany). The measurement of the luminescence intensity was carried out in two repetitions. Residual luminescence (T, %), calculated as the ratio of the average maximum luminescence intensities of the experimental measurement (solution) and the control measurement, multiplied by 100%, was used as an integral indicator. Results. The results of bioluminescent testing of sterile solutions showed that “Maxima” solution exhibited the greatest inhibition of bioluminescence, while “Optimed” (Russia) and “AVIZOR Aqua Soft Comfort” solutions demonstrated the least effect. “Bausch + Lomb Biotrue” solution did not affect the bioluminescence. The results of bioluminescence testing of the solutions after contact lenses that had previously been worn for 10 hours were stored in them, showed a strong inhibition of bioluminescence in all solutions. Conclusion. The results of the toxicity evaluation allow for a more reliable prognosis of the long-term consequences of using certain solutions by contact lens wearers from risk groups. The findings also provide more insight into the mechanisms of development of discomfort and other reasons for refusing to wear lenses, as well as to suggest more effective prevention measures.
New morphological risk factors for metastasis to regional lymph nodes in rectal cancer with invasion into the submucosa
Authors: Maynovskaya O. A. , Rybakov E. G. , Chernyshov S. V. , Shelygin Yu. A. , Achkasov S. I. 
Published: December 2021

AIM to assess prognostic significance of pathologic features of T1 rectal carcinoma in relation to regional lymph nodes involvement (N+).MATERIAL AND METHODS: surgical specimens (n = 66) from rectal resection for carcinoma pT1 were investigated. Following prognosticators were evaluated: depth of submucosal invasion, grade of differentiation, lymphovascular invasion (LVI), tumor budding (Bd), poorly differentiated clusters (PDC) of tumor and rupture of cancer glands (CGR).RESULTS: lymph nodes metastases were found in 13 (19.7%) specimens. LVI was associated lymphatic spread in great possibility OR 38.0 95% CI 2.1-670 (p < 0.0001). Tumor budding of high grade (Bd3) OR 6.2 95% CI 1.2-31 (p < 0.0001) and poorly differentiated clusters (p = 0,03) also increased risk of lymph node metastases. Depth of submucosal invasion, grade of differentiation, and rupture of cancer glands failed to demonstrate significant association with N+. Logistic regression analysis allowed to determine LVI as independent prognostic factor of lymph node tumor involvement.CONCLUSION: lymphovascular invasion, tumor budding and poorly differentiated clusters of tumor are risk factors of T1 rectal carcinoma lymph node metastases.
The effectiveness of combined topical product with fluocortolone pivalate and lidocaine for hemorrhoids: results of a multicenter observational study
Authors: Kostarev I. V. , Agapov M. A. , Groshilin V. S. , Dvaladze L. G. , Tvorogov D. A. , Churgulia M. Z. 
Published: December 2021

AIM: to assess the changes in hemorrhoids symptoms and satisfaction with treatment against the background of treatment with a combined topical product Relief® Pro.PATIENTS AND METHODS:multicenter prospective non-interventional cohort study was done in 13 clinical centers in Russia. The study included patients aged 18 to 65 years with acute hemorrhoids of stages 1–2 treated with the combined product Relief® Pro (rectal suppositories, cream or a combination thereof). The follow-up period was up to 14 days (in the case of 2 visits to the clinical center after receiving the initial data). The analysis was performed on the basis of data obtained at Visit 2 (5–7 days of therapy) and Visit 3 (10–14 days of therapy) vs the initial data (Visit 1). Following criteria were used: the severity of hemorrhoid symptoms on the Sodergren scale, the severity of hemorrhoid symptoms (pain, bleeding, itching, edema, the presence of discharge, a feeling of discomfort), the size of the largest hemorrhoid node, the satisfaction of the doctor and the patient with treatment, assessment of the patient’s adherence to recommendations for lifestyle changes and treatment, evaluation of the use of the drug Relief® were evaluated as endpoints About the treatment process and patient preferences regarding the dosage form of the prescribed drug. In addition, adverse events were evaluated.RESULTS: the study included 1000 patients aged 18 to 65 years (men — 54.5%, women — 45.5%) Patients had grade 1 acute hemorrhoids (330 patients), grade 2 acute hemorrhoids (345 patients) and exacerbation of chronic hemorrhoids (325 patients). The drug Relief® Pro rectal cream was used by 333 patients; suppositories — 383 patients; joint therapy with both dosage forms — 284 patients. During follow-up (visits 2 and 3), positive dynamics was observed in patients — a decrease in the severity of hemorrhoid symptoms both during objective examination and according to patient questionnaires. So, according to the patients’ estimates, the use of Relief® Pro, regardless of the form, led to a decrease in the severity or disappearance of the main symptoms of hemorrhoids — bleeding, itching, edema, the presence of discharge, discomfort already by Visit 2 and in almost all patients by the end of observation. A similar change of the symptoms due the digital examination: by day 5–7, the severity of edema and bleeding in the perianal region, bleeding decreased. About 96% of patients and about 97% of doctors were satisfied with the treatment. Application of both forms of Relief® The ABM was characterized by good tolerability: there were no adverse events associated, according to the researcher, with the studied drug.CONCLUSIONS: combined topical product Relief® Pro is effective for hemorrhoids.
Tamilarin Naattu Maruthuva Varalaaru (History of Indigenous Tamils Medicinal System)
Authors: Dhinakar R , Subasree T 
Published: December 2021

Tamils have their indigenous system of Traditional medicine (Siddha medicinal system) which developed through ages, from the dream time in the past and still evolving. This system of medicine did not evolve in a single day, it took a prolonged period, through vast experience gathered through observation of the human body, and its symptoms towards diseases and examination of thousands of herbs, metals, and minerals to cure the diseases. This skill and wisdom have been passed over generations which made this system one of the most efficient medicinal systems of our time. But over time this Tamil system of medicine was suppressed and underestimated in the name of modern science, the biased-prejudiced propaganda and hatred spread by huge pharma groups against this system, to prove that this system of medicine is irrational and unscientific which not true. Same time the lack of support from the government side in the previous years to enhance this Tamil Siddha medicinal system, made the scenario favor western medicinal pharma groups. However, the scenarios are been changing with the wakening of Tamils’ political and historical consciousness. It is for sure that soon Tamil’s traditional system of Medicine will retrieve and rise with its unique philosophy and virtue.
Teoría fundamentada como referente metodológico en el cuidado de enfermería
Authors: Cervantes-Lara Claudia Alejandra , Casique-Casique Leticia , Álvarez-Aguirre Alicia 
Published: December 2021

Enfermería es una disciplina práctica que, a través de la investigación, teorías de rango medio, proyectos de gestión, entre otros, está consolidando su cuerpo de conocimientos. Es a partir de la investigación que se delimita el objeto de conocimiento y se evidencia qué, cómo, por qué y para qué se hace.
Es importante mencionar que la investigación en enfermería se aborda desde tres enfoques: cualitativo, cuantitativo y complementario o mixto, los cuales surgieron para indagar determinados fenómenos e incluso el estudio de lo que nos rodea.
El enfoque cuantitativo representa un proceso secuencial que permite comprobar algunas suposiciones, lleva un orden riguroso y las unidades analizadas se vinculan a mediciones obtenidas de las que se extraen conclusiones acordes a la o a las hipótesis planteadas previamente, dado que los resultados se pretenden generalizar y difundir, pues se basa en la lógica o razonamiento deductivo, es decir, que inicia de lo general para concluir en lo particular.
Designação e reescritura em textos de divulgação científica
Authors: Melo de Oliveira Maria Elizete , Leão Leonildes Lima Colaço Teixeira de Arêa Leão , Lima Paulo da Silva Lima 
Published: December 2021

Este artigo objetiva analisar os processos de designação e reescritura no Texto de Divulgação Científica destinado ao público infantil a partir da Semântica da Enunciação, partindo da premissa de que o sentido dos enunciados está inserido no acontecimento da enunciação. Para isso, tomamos por base teórica Guimarães (2009, 2014, 2018), Machado (2019) e Silva (2019). Discutimos a proposta tomando como corpus Textos de Divulgação Científica retirados da versão online da revista Ciência Hoje das Crianças (CHC), nos quais analisamos os processos de designação e reescritura e o modo que atuam na construção dos sentidos dos enunciados. Diante disso, pudemos constatar que a designação e a reescritura estabelecem relações de sentido na construção dos textos permitindo aos interlocutores participarem do acontecimento enunciativo por meio da compreensão dos enunciados.
PALAVRAS-CHAVE: Semântica da Enunciação; Designação; Reescritura; Divulgação Científica.
ANALISIS BISNIS DIGITAL (SKEMA PONZI DAN SKEMA PIRAMIDA) DI ERA REVOLUSI INDUSTRI 4.0 BAGI MASYARAKAT DI KABUPATEN KOTABARU BERDASARKAN UU NO. 8 TAHUN 1995 TENTANG PASAR MODAL DAN UU NO. 7 TAHUN 2014 TENTANG PERDAGANGAN
Authors: Grenada Floren  
Published: December 2021

Abstract: The ignorance of the people, especially those living in Kotabaru Regency regarding the existence and implementation of Law no. 08 of 1995 concerning the capital market and Law no. 7 of 2014 concerning trade, is used by illegal business actors to implement Ponzi schemes, pyramid schemes and insider trading on the businesses they offer. This study aims to find out about the development of digital business in the industrial revolution era, the implementation of Law no. 8 of 1995 concerning the capital market and Law no. 7 of 2014 concerning Trade in digital business, providing knowledge in choosing the right and appropriate digital business products. The sampling technique used was Quota sampling which was carried out on 50 respondents spread over 6 Districts in Kotabaru Regency. The qualitative descriptive analysis technique uses the scoring results from the questionnaire, for the results of the questionnaire with negative indications, further observations are carried out using purposive/judgmental techniques. From the results of the research, it was found that there are still many people who are entangled in illegal businesses.
Keywords: Ponzi Scheme, Pyramid Scheme, Law No. 8 of 1995 concerning Markets Capital and Law no. 7 of 2014 concerning Trade

Abstrak : Ketidaktauan masyarakat khususnya yang tinggal di Kabupaten Kotabaru mengenai keberadaan dan pengimplementasian UU No. 08 Tahun 1995 tentang pasar modal dan UU No. 7 Tahun 2014 tentang perdagangan, dimanfaatkan oleh oknum pelaku bisnis ilegal untuk menerapkan skema Ponzi, skema piramida dan insider trading pada bisnis yang mereka tawarkan. Penelitian ini bertujuan untuk mengetahui mengenai perkembangan bisnis digital pada era revolusi industri, implementasi UU No. 8 Tahun 1995 Tentang pasar modal dan UU No. 7 Tahun 2014 Tentang Perdagangan pada bisnis digital, memberikan pengetahuan dalam memilih produk bisnis digital tepat dan sesuai. Teknik pengambilan sampel menggunakan Quota sampling yang dilakukan pada 50 orang responden yang tersebar pada 6 Kecamatan di Kabupaten Kotabaru. Teknik analisis deskriptif kualitatif menggunakan hasil skoring dari kusioner, untuk hasil kuisioner berindikasi negatife di lakukan pengamatan lanjutan menggunakan teknik purposive/judgmental. Dari hasil penelitan di temukan masih banyak masyarakat yang terjerat dalam bisnis ilegal.

Kata Kunci : Skema Ponzi, Skema Piramida, UU No.8 Tahun 1995 Tentang Pasar Modal dan UU No. 7 Tahun 2014 Tentang Perdagangan
ANALISA PENGARUH PEKERJA SECARA MENTAL, GAJI, KESEMPATAN PROMOSI, KONDISI KERJA DAN KESESUAIAN PRIBADI PEKERJA TERHADAP KINERJA PEGAWAI PADA KANTOR PELAYANAN PAJAK MUARA TEWEH
Authors: Tania Jannah  
Published: December 2021

Abstrak :Tania Jannah, Pengaruh pekerja secara mental, gaji, kesempatan promosi, kondisi kerja dan kesesuaian pribadi pekerja terhadap kinerja pegawai kantor pelayanan pajak muarateweh, Pembimbing Utama: Risadiro Cahyono Pembimbing Pembantu: Asruni
Penelitian ini bertujuan untuk menguji Analisa yang mempengaruhi kinerja pegawai kantor pelayanan pajak muara teweh. Permasalahan umum dalam penelitian ini adalah dimana kurangnya Pengaruh mental, gaji, kesempatan promosi, kondisi kerja dan kesesuaian pribadi pekerja terhadap Kinerja Pegawai Pada kantor pelayanan pajak muara teweh, dimana kinerja pegawai menurun sehingga peneliti perlu mengetahui pengaruh variabel mana yang mempengaruhi kinerja pegawai pada kantor pelayanan pajak muara teweh
Populasi dalam penelitian ini ialah 50 Pegawai Pada kantor pelayanan pajak muara teweh, data diambil dari kuesioner yang dibagikan kepada responden. Variabel dalam penelitian ini adalah variabel bebas (Independent) mental, gaji, kesempatan promosi, kondisi kerja dan kesesuaian pribadi pekerja sedangkan variabel terikatnya (dependent) adalah Kinerja Pegawai. Data dianalisis dengan menggunakan SPSS Versi 25.
Hasil penelitian menunjukkan bahwa Secara Simultan mental, gaji, kesempatan promosi, kondisi kerja dan kesesuaian pribadi pekerja berpengaruh signifikan terhadap kinerja pegawai kantor pelayanan pajakmuara teweh. secara parsial mental, gaji, kesempatan promosi, kondisi kerja dan kesesuaian pribadi pekerja berpengaruh signifikan terhadap kinerja pegawai pada kantor pelayanan pajak muara teweh.

Kata Kunci : mental, gaji, kesempatan promosi, kondisi kerja kesesuaian pribadi pekerja, kinerja pegawai
Robust Attention Deraining Network for Synchronous Rain Streaks and Raindrops Removal
Authors: Wei Yanyan , Zhang Zhao , Xu Mingliang , Hong Richang , Fan Jicong , Yan Shuicheng 
Published: December 2021

<p>Please cite this work as </p>
<p><br></p>
<p>Yanyan Wei, Zhao Zhang, Mingliang Xu, Richang Hong, Jicong Fan and Shuicheng Yan, "Robust Attention Deraining Network for Synchronous Rain Streaks and Raindrops Removal," In: Proceedings of the 30th ACM International Conference on Multimedia (ACM MM), Lisbon, Portugal, June 2022. </p>
AGRICULTURAL EMERGENCY: IDENTIFYING RISK BASED ON AGRICULTURAL HEALTH NURSING
Authors: Suhari Suhari , Mashuri Mashuri , Abidin Zainal 
Published: December 2021

Abstract
Objective: The aim of the study was to identify the integrated emergency risks of farmers based on nursing models in the agricultural area of Lumajang, Indonesia.Materials and Methods: A quantitative design with a descriptive approach was performed through the identification of threats, vulnerabilities, and capabilities in 357 farmers in integrated emergency response with cluster sampling techniques. Data was collected through questionnaires, interviews, and focus group discussions. Data analysis was carried out using the Job Safety Analysis scoring method of the Australian and New Zealand Standard on Risk Management. Results: The emergency risk of farmers based on agricultural nursing was the high category, the highest threat was direct contact with chemicals (95%), the highest contact chemicals are insecticides (57%), frequency of contact once a week (44%), and the highest vulnerability not having employment insurance (97%), the length of farming > 10 years (65%) and the length of work in 1 month 10-20 days (48%), long work on land 8-10 hours (5%) and no holiday in a month (20%), while the capability of farmers in first aid to accidents was low (44%).Conclusion: The emergency risk of farmers in Lumajang was high and the capability for emergency-response based on agricultural nursing was low.

Keywords: Threats, vulnerabilities, capabilities, emergencies, farmers, agricultural nursing
ANXIETY OF HEMODIALYSIS PATIENT WITH ACCESS ARTERIOVENOUS FISTULA (AV-SHUNT): A QUALITATIVE STUDY
Authors: Nafisah Siti , Irawati Meira , Hidayati Wahyu 
Published: December 2021

Background: Cannulation is an intervention that inserts a needle through the skin into a blood vessel. Av-shunt is the most recommended access for use in the hemodialysis therapy process. Psychosocial problems, especially feelings of anxiety and fear can be felt by patients due to AV-shunt. Anxiety is a scientific attitude experienced by each individual as a form of response in dealing with problems or threats Vascular access complications may threaten lives and reduce treatment satisfaction and life quality. Objectives: This study aimed to describe hemodialysis patient anxiety with arteriovenous fistula (AV-shunt) access. Methods: A descriptive qualitative study using the in-depth interview method with phenomenology approach. The study was carried out with four informants undergoing hemodialysis in RSUD dr. Haryoto Lumajang. Samples were taken using purposive sampling. Participant statements were recorded using a voice recorded, transcribed, coded, interpreted, and categorized to create a theme. Results: The study results produced three themes: (1) Emotional feeling perceived associated with AV-shunt experience: Anxiety, fear, and helplessness, (2) Physical and physical activity changes: Dark skin, dry skin, limp body, and fatigue, and (3) Patient knowledge regarding av-shunt, i.e., AV-shunt access and based on information sources. Conclusion: Patients with arteriovenous fistula (AV-shunt) access had anxieties caused by cannulation initial pain, fear, and sense of uselessness.
RELATIONSHIP BETWEEN STRESS LEVELS AND ONLINE GAME ADDICTION IN ADOLESCENTS
Authors: Nur Hidaayah  , Yunitasari Esti , Nihayati Hanik Endang , Faizah Imamatul , Makhsusoh Hilliyatul Aulia , Purwanti Nunik 
Published: December 2021

Background: Factors that trigger stress in adolescents are academic, interpersonal, and family stress. The teenager will feel happy just by playing various game online applications contained in smartphones, but the problems that were previously faced were not resolved.
Objectives: This study aimed to determine the relationship between stress levels and online game addiction in adolescents at Hidayatul Ummah High School Surabaya.
Methods: This study used an observational approach with a cross-sectional method. The population in this study were all students of classes X, XI, and XII, totaling 80 students. The sample size is 80 students with the Simple Random Sampling method. Data analysis using Spearman Rank test. The variables in this study are stress levels and online game addiction. The instrument used to measure stress level is a Perceived Stress Score (PSS) and Measurement of game addiction using the Indonesian Online Game Addiction Questionnaire.
Results: The results of data analysis using the Spearman Rank test with the results = 0.002 which means there is a significant relationship between stress levels and online game addiction in adolescents at Hidayatul Ummah High School Surabaya. The results in this study were the students of grades X, XI, and XII at Hidayatul Ummah High School Surabaya experienced a moderate level of stress with online game addiction in the category of severe addiction.
Conclusion: The level of stress with online game addiction carried out at Hidayatul Ummah High School Surabaya mostly experienced moderate stress levels and heavy category addiction to online games.
Flight screening of military pilots in Poland
Authors: Bogusz Dariusz 
Published: December 2021

This article diagnoses and evaluates the process of selecting and preparing candidates for military pilots in Poland. The presented changes in the screening training system are to help with understanding the principles of organizing an effective system of recruitment and selection of military pilots at present. It also indicates directions for improvement. The organization of initial flight screening contributes to improving the efficiency of flight training and can serve as a model for use by flight training systems in other countries.
The purpose of the article is to diagnose and evaluate recruitment and selection of candidates for military pilots in Polish Armed Forces.
The problem that the author addresses is expressed in the following question: in what directions should the current solutions in the selection and training of candidates for military pilots, be improved in order to reduce the attrition rate at subsequent stages of flight training in the future?
The research has been conducted at the Military University of Aviation using case study methods. The theoretical research methods, such as analysis and synthesis of information contained in literature and source materials, conclusions and comparison were used to develop the article. In order to confirm the conclusions drawn with the use of theoretical methods, an empirical method was used, which consisted in examining the opinions with the use of expert interviews. Experts were selected from the group of commanders of training units and military pilots involved in selection training, who had an impact on the applicable aviation training and recruitment system in Polish Armed Forces.
The results shows main directions of military pilots initial flight screening improvement.