bluuebunny/crossref_metadata_2025_split huggingface dataset:
A potent truncated form of human soluble CR1 is protective in a mouse model of renal ischemia–reperfusion injury
Authors: Bongoni Anjan K. , Vikstrom Ingela B. , McRae Jennifer L. , Salvaris Evelyn J. , Fisicaro Nella , Pearse Martin J. , Wymann Sandra , Rowe Tony , Morelli Adriana Baz , Hardy Matthew P. , Cowan Peter J. 
Published: November 2021

AbstractThe complement system is a potent mediator of ischemia–reperfusion injury (IRI), which detrimentally affects the function and survival of transplanted kidneys. Human complement receptor 1 (HuCR1) is an integral membrane protein that inhibits complement activation by blocking the convertases that activate C3 and C5. We have previously reported that CSL040, a truncated form of recombinant soluble HuCR1 (sHuCR1), has enhanced complement inhibitory activity and improved pharmacokinetic properties compared to the parent molecule. Here, we compared the capacity of CSL040 and full-length sHuCR1 to suppress complement-mediated organ damage in a mouse model of warm renal IRI. Mice were treated with two doses of CSL040 or sHuCR1, given 1 h prior to 22 min unilateral renal ischemia and again 3 h later. 24 h after reperfusion, mice treated with CSL040 were protected against warm renal IRI in a dose-dependent manner, with the highest dose of 60 mg/kg significantly reducing renal dysfunction, tubular injury, complement activation, endothelial damage, and leukocyte infiltration. In contrast, treatment with sHuCR1 at a molar equivalent dose to 60 mg/kg CSL040 did not confer significant protection. Our results identify CSL040 as a promising therapeutic candidate to attenuate renal IRI and demonstrate its superior efficacy over full-length sHuCR1 in vivo.
Interval Training with Different Intensities in
Overweight/Obese Adolescent Females
Authors: Abassi Wissal , Ouerghi Nejmeddine , Nikolaidis Pantelis T. , Hill Lee , Racil Ghazi , Knechtle Beat , Feki Moncef , Bouassida Anissa 
Published: November 2021

AbstractTo compare the effects of 12 weeks of high-intensity interval training (HIIT)
versus moderate-intensity interval training (MIIT) on hematological and
inflammatory markers in youth females, 38 overweight/obese females
(16.4±1.0 yrs.) were randomly assigned to HIIT
(2×6–8 repetitions of 30 s at 100–110%
maximal aerobic speed (MAS), with 30 s active recovery between
repetitions at 50% MAS; n=13), MIIT (2×6–8
repetitions of 30 s at 70–80% MAS, with 30 s
active recovery between repetitions at 50% MAS; n=13), and a
control group (CG, no intervention; n=12). Body composition, blood
pressure, maximal heart rate, hematological and inflammatory markers (C-reactive
protein [CRP], and erythrocyte sedimentation rate [ESR]) markers were assessed
in all groups before and following the training program. Results revealed a
significant (P<0.05) interaction effect for body composition, systolic
blood pressure (SBP), MAS, maximal heart rate, and CRP. Within-group analyses
for the HIIT and MIIT groups showed significant improvements in body mass
(P=0.009 and P=0.025, respectively), BMI Z-score
(P=0.011 and P=0.028, respectively), and MAS (P<0.001
and P=0.011, respectively). The HIIT program showed a significant
decrease in body fat (P=0.002), waist circumference (P=0.002),
maximal heart rate (P=0.003), SBP (P=0.001), and plasma CRP
(P=0.004). In both groups, no signiﬁcant changes were observed
in ESR and hematological markers after intervention. No variable changed in CG.
HIIT was the effective method to manage cardiometabolic health and inflammatory
disorders in obese youth.
Postpartum Hemorrhage in Patients with Type 1 von Willebrand Disease: A Systematic Review
Authors: Pierce-Williams Rebecca A.M. , Makhamreh Mona M. , Blakey-Cheung Sophia , Gao Zimeng , Al-Kouatly Huda B. 
Published: November 2021

AbstractType 1 von Willebrand disease (VWD) is the most common subtype of VWD, comprising 75% of VWD patients. We provide a systematic review of type 1 VWD in pregnancy. Our objective was to evaluate the rate of postpartum hemorrhage (PPH) in patients with known type 1 VWD. The primary outcome was rate of PPH. Primary PPH was defined as a cumulative blood loss ≥1,000 mL, or blood loss accompanied by signs and symptoms of hypovolemia within 24 hours postpartum or requiring blood products. Secondary PPH was defined as significant bleeding 24 hours to 12 weeks postpartum. Relevant articles published in English pertaining to VWD and pregnancy were identified without any time or study limitations. Seven articles (n = 144 pregnancies) met inclusion criteria. The rate of primary PPH was 4/144 (2.8%). The secondary PPH rate was reported in four studies, and occurred in 7/48 pregnancies (14.6%), ranging from 2 to 19 days postpartum. In conclusion, according to this systematic review, the frequency of primary PPH in pregnancies with known type 1 VWD is 2.8%. This is similar to the overall PPH rates of 3% reported in the literature. Although the sample size was small, secondary PPH occurred in almost 15% of pregnancies, while in the overall obstetrical population this occurs in approximately 1% of cases. Patients with known type 1 VWD may not be at increased risk of primary PPH, though they appear to bear increased risk of secondary PPH.
Geometric frustration produces long-sought Bose metal phase of quantum matter
Authors: Hegg Anthony , Hou Jinning , Ku Wei 
Published: November 2021

Significance
Traditional bosonic lore is dictated by the binary dynamics of perfect flow or no flow. In recent decades, empirical observations support the unexpected phenomenon of bosons exhibiting dissipative transport at low temperature. Several specialized theories attempt to explain this surprising phenomenon, but a universal theory more representative of experimental observations is lacking. We propose a scenario in which frustration confines the low-energy transport to a lower dimension. The result is a failed insulator state where gapless insulating behavior exhibits dissipative transport at finite temperature or through weak disorder. This result modifies our fundamental understanding of bosons by producing a phase of quantum matter intervening between superfluid and insulator.
A regulatory network of microRNAs confers lineage commitment during early developmental trajectories of B and T lymphocytes
Authors: Nikhat Sameena , Yadavalli Anurupa D. , Prusty Arpita , Narayan Priyanka K. , Palakodeti Dasaradhi , Murre Cornelis , Pongubala Jagan M. R. 
Published: November 2021

Significance
MicroRNAs (miRNAs) are a family of noncoding RNAs that regulate gene expression by posttranscriptional mechanisms. They are important for cell differentiation and were found to be misregulated in several immune disorders. However, the genes regulated by miRNAs during lymphocyte development remain largely unknown. Here, we show that miRNAs are conserved between early–B and early–T cells, but they target genes associated with natural killer, dendritic cell, and myeloid lineages in a cell type–specific manner. Knockdown and overexpression studies show miRNAs play an important role in the sustenance of lineage-specific gene expression programs and thereby enforce lymphoid cell-fate commitment. These studies provide insights into the role of miRNAs in the maintenance of lineage identity and regulation of cell-fate decisions.
How the interplay of molecular and colloidal scales controls drying of microgel dispersions
Authors: Roger Kevin , Crassous Jérôme J. 
Published: November 2021

Significance
Microgel aqueous dispersions are shown to display drying behavior in between that of a colloidal dispersion and a polymer solution. Like a colloidal dispersion, drying proceeds through the propagation of a drying front separating a dense film from the dispersion’s bulk. However, microgels are able to deform, interpenetrate, and deswell, which allows them to compact further than hard-sphere close packing, similarly to polymers. A steep and complex water gradient thus exists throughout the film, along which both water activity and water transport strongly decrease toward the air/liquid interface. The weak influence of the air relative humidity on the drying process illustrates the interplay between water activity and water transport, which stems from water deprivation in mesostructures at the air/liquid interface.
Plastic waste release caused by COVID-19 and its fate in the global ocean
Authors: Peng Yiming , Wu Peipei , Schartup Amina T. , Zhang Yanxu 
Published: November 2021

Significance
Plastic waste causes harm to marine life and has become a major global environmental concern. The recent COVID-19 pandemic has led to an increased demand for single-use plastic, intensifying pressure on this already out-of-control problem. This work shows that more than eight million tons of pandemic-associated plastic waste have been generated globally, with more than 25,000 tons entering the global ocean. Most of the plastic is from medical waste generated by hospitals that dwarfs the contribution from personal protection equipment and online-shopping package material. This poses a long-lasting problem for the ocean environment and is mainly accumulated on beaches and coastal sediments. We call for better medical waste management in pandemic epicenters, especially in developing countries.
Enhanced mechanical properties of Mg–Ni–xRE alloys via hot extrusion
Authors: Rezaei Moghadam Mahdi , Malekan Mehdi , Emamy Massoud , Mirzadeh Hamed 
Published: November 2021

The effects of mischmetal addition and hot working on the enhancement of microstructure and mechanical properties of Mg–Ni alloys were studied. It was revealed that grain refinement could be achieved by introducing rare earth (RE) elements in the as-cast condition, and more pronouncedly, by the extrusion process in the wrought condition. While the formation of intergranular brittle phases via RE addition impaired the as-cast mechanical properties, the remarkable grain refinement and fragmentation and dispersion of intermetallic particles significantly improved the mechanical properties in the extruded condition. The ultimate tensile strength and total elongation of the extruded Mg–1.5Ni–3RE alloy with an average grain size of 3.18 μm (347 MPa and 9%) were much larger than those for the as-cast counterpart (140 MPa and 3%).
Spatial and temporal distribution characteristics of ground-level nitrogen dioxide and ozone across China during 2015–2020
Authors: Li Yanfen , Shi Guitao , Chen Zhenlou 
Published: November 2021

Abstract
In recent years, the emissions control in nitrogen oxides (NO
x
) was conducted across China, but how the concentrations of NO
x
and its product ozone (O3) in the atmosphere varied in space and time remains uncertain. Here, the spatial and temporal distributions of nitrogen dioxide (NO2) and O3 in 348 cities of China based on the hourly concentrations data during 2015–2020 were investigated, and the relationships among NO2, O3 and meteorological and socioeconomic parameters were explored. It is shown that higher NO2 and O3 concentrations were mainly distributed in North, East and Central China, which are economically developed and densely populated regions. The annual mean concentrations of NO2 increased from 2015 to 2017 but decreased from 2017 to 2020. The annual variations in O3 generally exhibited an upward trend in 2015–2019 but decreased by 5% from 2019 to 2020. About 74% and 78% of cities had a decline in NO2 and O3 in 2020, respectively, compared to 2019, due to the limits of the motorized transports and industrial production activities during COVID-19 lockdown. The monthly mean concentrations of NO2 showed an unusual decrease in February in all regions due to the reduced emissions during the Chinese Spring Festival holidays. Compared to 2019, the mean concentrations of NO2 in January, February and March, 2020 during COVID-19 lockdown decreased by 16%, 28% and 20%, respectively; O3 increased by 13% and 14% in January and February, respectively, but decreased by 2% in March, 2020. NO2 and O3 concentrations are likely associated with anthropogenic and natural emissions. In addition, meteorological parameters can affect NO2 and O3 concentrations by influencing the production process, the diffusion and local accumulation, and the regional circulations.
Position-dependent mass in strong quantum gravitational background fields
Authors: Lawson Latévi Mohamed 
Published: November 2021

Abstract
More recently, we have proposed a set of noncommutative space that describes the quantum gravity at the Planck scale (2020 J. Phys. A: Math. Theor.
53 115303). The interesting significant result we found is that, the generalized uncertainty principle induces a maximal measurable length of quantum gravity. This measurement revealed strong quantum gravitational effects at this scale and predicted a detection of gravity particles with low energies. In the present paper, to make evidence this prediction, we study in this space, the dynamics of a particle with position-dependent mass (PDM) trapped in an infinite square well. We show that, by increasing the quantum gravitational effect, the PDM of the particle increases and induces deformations of the quantum energy levels. These deformations are more pronounced as one increases the quantum levels allowing, the particle to jump from one state to another with low energies and with high probability densities.
Effect of fungicidal agents on the initial growth of spring wheat plants
Authors: Timofeev VN , Vyushina O A , Ramazanova V S 
Published: November 2021

AbstractThis study provides a comparative assessment of the effectiveness of active ingredients of fungicidal preparations and in a mixture with organomineral fertilizers on reducing the infection of seed and the germination of spring wheat plants in the initial phases of ontogenesis. For the research, on 8 different combinations of active ingredients fungicides in pure form and in a mixture with organomineral fertilizer. The application of fungicide did not affect the seed growth energy, but in most cases the germination rate increased by 4%. Seed dressing had a retardant effect on germination of the plant’s organs, and the fertiliser stimulating effect was shown in Variant 1 (Protioconazole + Tebuconazole + fertiliser). The efficiency of disinfectants against seed diseases reached 96% against general contamination and 56-93% against pathogenic microflora, and in a mixture with organomineral fertilizer, the efficiency is reduced by 13%. High and stable efficiency was manifested in drugs based on the active substances Tebuconazole + Flutriafol (80 + 80 g/l). Protioconazole + Tebuconazole (250+150 g/l) with net efficiency of 83-93%. As a result of the research, the effect of pickling with fungicides was determined on the basis of various combinations of active substances in pure form and with the addition of organomineral fertilizer as a growth stimulator.
The effect of carbon dioxide on the production of potato minitubers under aeroponic cultivation
Authors: Papikhin R V , Rukhov A V , Pugacheva G M , Muratova S A , Chusova N S , Nikonov K G 
Published: November 2021

Abstract
The paper presents data on the effect of additional top dressing of potato plants with CO2 at a concentration of 2500 ppm cultivated in aeroponic plants. It was found that the increased concentration of CO2 provides better development of plant shoots (128.6%) and the root system (120.1%) relative to the control: a larger yield (123.7%) with a larger fraction of minicubes is formed, and the number of plants capable of producing 1100-1600 g of minicubes during the cultivation period increases. Additional feeding of CO2 at a concentration of 2500 ppm leads to an increase in the mass of plants, which occurs not due to increased hydration of tissues, but due to the accumulation of dry substances.
Gluten-free products from chickpea flour
Authors: Necheporuk A G , Tretyakova E N , Danilin S I , Toporkova K I , Pershikova A G 
Published: November 2021

Abstract
The paper discusses the possibility of the expansion of the range of flour culinary products for a gluten-free diet using chickpea flour. The analysis of the chemical composition of wheat and chickpea flour, as well as the glycemic index of all components of the recipe of the developed flour culinary product is presented. The possibility of partial and complete replacement of wheat flour with chickpea flour with the addition of caraway, lemon peel and potato starch is studied. It is found that the inclusion of lemon peel in the composition of chickpea flour pancakes improves not only the organoleptic characteristics of products, but also reduces its total energy content, while expanding the range of products included in a gluten-free diet.
Study of toxic elements in propolis
Authors: Vakhonina E A , Lapynina E P , Lizunova A S 
Published: November 2021

Abstract
There is a threat of heavy metals and toxic elements entering the beekeeping products in relation to the deterioration of the ecological situation. In this regard, a study of one of the most popular beekeeping products, propolis, from the territory of two regions of Russia (Ryazan Oblast and Krasnodar Krai) for the level of Pb, Cd, Sr and the toxic element As was undertaken. The studies were made from 2004 to 2019. The amount of elements was determined spectrophotometrically with an atomic absorption spectrophotometer Spectr AA 220FS. Lead, cadmium and strontium levels were determined using an air-acetylene flame on a gas atomizer. The level of arsenic was determined on a graphite oven of a spectrophotometer using a palladium modifier made by “Mersk”. The lead level in propolis was from 0 to 0.19 mg/kg that exceeds the threshold limit value by a factor of 1.2-12.3. The concentration of cadmium, strontium, arsenic in the studied propolis samples does not exceed the threshold limit value: 0-0.164 mg/kg, 2.1-21.01 mg/kg, 0-1.04 μm/kg, respectively. The accumulated experimental data indicate the need to adjust the threshold limit value (SanPiN 2.3.2. 1078-01) of lead level in propolis. The dynamics of propolis pollution with toxic elements was evaluated in the course of the research. The results of this evaluation confirmed the possibility of using propolis as a bioindicator of environmental pollution with heavy metals and toxic elements. It is necessary to monitor the propolis safety to determine its level of contamination with heavy metals and toxic elements, when using it as a source of biologically active compounds and as a raw material for Pharmacy (making extracts, tablets, ointments, syrups, suppositories, plasters).
Effect of p18 on endothelial barrier function by mediating vascular endothelial Rab11a-VE-cadherin recycling
Authors: Xu Bo-Wen , Cheng Zhi-Qiang , Zhi Xu-Ting , Yang Xiao-Mei , Yan Zhi-Bo 
Published: November 2021

ABSTRACT
Endothelial barrier integrity requires recycling of VE-cadherin to adherens junctions. Both p18 and Rab11a play significant roles in VE-cadherin recycling. However, the underlying mechanism and the role of p18 in activating Rab11a have yet to be elucidated. Performing in vitro and in vivo experiments, we showed that p18 protein bound to VE-cadherin before Rab11a through its VE-cadherin-binding domain (aa 1-39). Transendothelial resistance showed that overexpression of p18 promoted the circulation of VE-cadherin to adherens junctions and the recovery of the endothelial barrier. Silencing of p18 caused endothelial barrier dysfunction and prevented Rab11a-positive recycling endosome accumulation in the perinuclear recycling compartments. Furthermore, p18 knockdown in pulmonary microvessels markedly increased vascular leakage in mice challenged with lipopolysaccharide and cecal ligation puncture. This study showed that p18 regulated the pulmonary endothelial barrier function in vitro and in vivo by regulating the binding of Rab11a to VE-cadherin and the activation of Rab11a.
A conceptualisation of equitable social work practice with transgender and gender diverse communities
Authors: Kia Hannah , Göncü Kaan , Nation Kelendria , Gray Jodi , Usher Darren 
Published: November 2021

AbstractAlthough the experiences of transgender and gender diverse (TGD) people are increasingly recognised as relevant sites of inquiry in social work scholarship, empirically substantiated insights on equitable approaches to social work practice with TGD communities remain scant. In this qualitative study, we draw on semi-structured virtual interviews with TGD social service users in a Canadian province (n = 20), along with social workers in the same jurisdiction (n = 10), to generate knowledge on equitable social work practice with TGD populations. We rely on critical ecosystemic and intersectional lenses as guiding theoretical frameworks, together with constructivist approaches to grounded theory, to inform our analytical process. Our findings highlight that equitable social work practice with TGD communities may involve the following constituents: (1) accounting for social and historical context; (2) practising allyship by way of humility and reflexivity; (3) challenging cisnormativity interpersonally and organisationally and (4) promoting structural measures of trans inclusion to transform social work and social services. Drawing on our findings, we call on social work scholars, educators and practitioners to adopt various reflexive, relational, organisational and structural measures that promise to enhance social work’s contribution to greater equity and social justice for TGD communities.
Improving Care for Recently Diagnosed Inflammatory Bowel Disease Patients: Lessons Learned From a Patient-Centred, Mixed-Method Study
Authors: van Erp Liselot W , Neijenhuis Myrte K , Heida Wendy , Derwig Joost , Geleijns Caroline E , Groenen Marcel J M , Wahab Peter J 
Published: November 2021

Abstract

Background and Aims
Newly diagnosed inflammatory bowel disease [IBD] patients need to deal with the physical and emotional impact of the disease. We aimed to evaluate care for recently diagnosed IBD patients from the patient perspective and assess themes for improvement.

Methods
A mixed-method study with adult IBD patients 4–15 months after diagnosis was performed. First, relevant themes were identified through semi-structured interviews until data saturation. Next, a questionnaire assessing satisfaction with care [SATI-Q] was developed and validated with 15 items divided into two domains: medical care and information and psychosocial care. Higher scores indicate higher patient satisfaction [0–100].

Results
We interviewed 20 patients. Next, 84/107 patients completed the SATI-Q: 51% female, aged 37 years (interquartile range [IQR 25–58]), 36% Crohn’s disease, disease duration 9 months [IQR 6–12] and 74% in clinical remission. The median SATI-Q score was 82 [IQR 72–92]. Patients were more satisfied with medical care than with information and psychosocial care (score 92 [IQR 81–98] vs 74 [IQR 60–90], p &lt; 0.001). Patients were least satisfied with the attention given to IBD-related emotions and information on IBD medication, diet and future perspectives [77, 76, 57 and 54% of patients satisfied]. Patients [81%] preferred spoken information. Only 26–27% preferred brochures and websites.

Conclusions
In this study, the SATI-Q questionnaire was developed and validated to assess patient satisfaction with care in early IBD. Our findings suggest that psychosocial care and information on IBD medication, diet influence and future perspectives for recently diagnosed IBD patients require improvement.