bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flexible Film-Type Sensor for Electrochemical Measurement of Dopamine Using a Molecular Imprinting Method
Authors: Kishi Takumi , Fujie Toshinori , Ohta Hiroyuki , Takeoka Shinji 
Published: October 2021

Neurotransmitters, which are responsible for the signal transduction of nerve cells in the brain, are linked not only to various emotions and behaviors in our daily life, but also to brain diseases. Measuring neurotransmitters in the brain therefore makes a significant contribution to the progress of brain science. The purpose of this study is to develop a flexible thin film-type sensor that can electrochemically measure dopamine (DA) selectively and with high sensitivity. The thin-film sensor was prepared by printing gold colloidal ink on a polyimide film with a thickness of 25 µm—which the most flexible of the films examined that could maintain the buckling load (1 mN) required for insertion into the brain. The electrode (DA-PPy electrode) was then prepared by electropolymerization of polypyrrole (PPy) using DA as a template. The flexural rigidity of the sensor was 4.3 × 103 nNm, which is the lowest of any neurotransmitter sensors reported to date. When a DA solution (0–50 nM) was measured with the DA-PPy electrode using square-wave voltammetry (SWV), the slope of the calibration curve was 3.3 times higher than that of the PPy only negative control electrode, indicating an improvement in sensitivity by molecular imprinting with DA. The sensor was used to measure 0−50 nM norepinephrine (NE) and serotonin (5-HT), and the slope of the DA calibration curve at 0.24 V (19 ± 4.4 nA/nM) was much greater than those of NE (0.99 ± 3.3 nA/nM) and 5-HT (2.5 ± 2.4 nA/nM) because the selectivity for DA was also improved by molecular imprinting.
Influence of Aging on Bioaccumulation and Toxicity of Copper Oxide Nanoparticles and Dissolved Copper in the Sediment-Dwelling Oligochaete Tubifex tubifex: A Long-Term Study Using a Stable Copper Isotope
Authors: Thit Amalie , Sandgaard Monica Hamann , Sturve Joachim , Mouneyrac Catherine , Baun Anders , Selck Henriette 
Published: October 2021

For engineered metal nanoparticles (NPs), such as copper oxide (CuO) NPs, the sediment is recognized as a major compartment for NP accumulation. Sediment-dwelling organisms, such as the worm Tubifex tubifex, will be at particular risk of metal and metal NP exposure. However, a range of complex transformation processes in the sediment affects NP bioavailability and toxicity as the contamination ages. The objective of this study was to examine bioaccumulation and adverse effects of CuO NPs in T. tubifex compared to dissolved Cu (administered as CuCl2) and the influence of aging of spiked sediment. This was done in a 28-day exposure experiment with T. tubifex incubated in clean sediment or freshly spiked sediment with different concentrations of dissolved Cu (up to 230 μg g−1 dw) or CuO NPs (up to 40 μg g−1 dw). The experiment was repeated with the same sediments after it had been aged for 2 years. To obtain a distinct isotopic signature compared to background Cu, both Cu forms were based on the stable isotope 65Cu (&gt;99%). The 28-day exposure to sediment-associated dissolved 65Cu and 65CuO NPs resulted in a clear concentration-dependent increase in the T. tubifex65Cu body burden. However, despite the elevated 65Cu body burdens in exposed worms, limited adverse effects were observed in either of the two experiments (e.g., above 80% survival in all treatments, low or no effects on the growth rate, feeding rate, and reproduction). Organisms exposed to aged sediments had lower body burdens of 65Cu than those exposed to freshly spiked sediments and we suggest that aging decreases the bioavailability of both 65Cu forms. In this study, the use of a stable isotope made it possible to use environmentally realistic Cu concentrations and, at the same time, differentiate between newly accumulated 65Cu and background Cu in experimental samples despite the high background Cu concentrations in sediment and T. tubifex tissue. Realistic exposure concentrations and aging of NPs should preferably be included in future studies to increase environmental realism to accurately predict the environmental risk of metal NPs.
Microscale Thermal Modelling of Multifunctional Composite Materials Made from Polymer Electrolyte Coated Carbon Fibres Including Homogenization and Model Reduction Strategies
Authors: Schutzeichel Maximilian Otto Heinrich , Kletschkowski Thomas , Monner Hans Peter 
Published: October 2021

Polymer electrolyte coated carbon fibres embedded in polymeric matrix materials represent a multifunctional material with several application scenarios. Structural batteries, thermal management materials as well as stiffness adaptive composites, made from this material, are exposed to significant joule heat, when electrical energy is transferred via the carbon fibres. This leads to a temperature increase of up to 100 K. The thermal behaviour of this composite material is characterized in this numerical study based on a RVE representation for the first time. Compared to classical fibre reinforced plastics, this material comprises a third material phase, the polymer electrolyte coating, covering each individual fibre. This material has not been evaluated for effective thermal conductivity, specific heat and thermal behaviour on the microscale before. Therefore, boundary conditions, motivated from applications, are applied and joule heating by the carbon fibres is included as heat source by an electro-thermal coupling. The resulting temperature field is discussed towards its effect on the mechanical behaviour of the material. Especially the temperature gradient is pronounced in thickness direction, leading to a temperature drop of 1 °Cmm, which needs to be included in thermal stress analysis in future thermo-mechanically coupled models. Another important emphasis is the identification of suitable homogenization and model reduction strategies in order to reduce the numerical effort spent on the thermal problem. Therefore, traditional analytical homogenization methods as well as a newly proposed “Two-Level Lewis-Nielsen” approach are discussed in comparison to virtually measured effective quantities. This extensive comparison of analytical and numerical methods is original compared to earlier works dealing with PeCCF composites. In addition, the accuracy of the new Two-Level Lewis-Nielsen method is found to fit best compared to classical methods. Finally, a first efficient and accurate 2D representation of the thermal behaviour of the PeCCF composite is shown, which reduces computational cost by up to 97%. This benefit comes with a different Temperature drop prediction in thickness direction of 1.5 °Cmm. In the context of future modelling of multifunctional PeCCF composite materials with multiphysical couplings, this deviation is acceptable with respect to the huge benefit for computational cost.
Flow Cytometry Immunophenotyping for Diagnostic Orientation and Classification of Pediatric Cancer Based on the EuroFlow Solid Tumor Orientation Tube (STOT)
Authors: Ferreira-Facio Cristiane de Sá , Botafogo Vitor , Ferrão Patrícia Mello , Canellas Maria Clara , Milito Cristiane B. , Romano Sérgio , Lopes Daiana V. , Teixeira Lisandra C. , Oliveira Elen , Bruno-Riscarolli Enrico , Mello Fabiana V. , Siqueira Patrícia F. R. , Moura Patrícia , Macedo Francisco Nicanor , Forny Danielle N. , Simião Luíza , Pureza Ana Luíza , Land Marcelo Gerardin Poirot , Pedreira Carlos Eduardo , Dongen Jacques J. M. van , Orfao Alberto , Costa Elaine Sobral da 
Published: October 2021

Early diagnosis of pediatric cancer is key for adequate patient management and improved outcome. Although multiparameter flow cytometry (MFC) has proven of great utility in the diagnosis and classification of hematologic malignancies, its application to non-hematopoietic pediatric tumors remains limited. Here we designed and prospectively validated a new single eight-color antibody combination—solid tumor orientation tube, STOT—for diagnostic screening of pediatric cancer by MFC. A total of 476 samples (139 tumor mass, 138 bone marrow, 86 lymph node, 58 peripheral blood, and 55 other body fluid samples) from 296 patients with diagnostic suspicion of pediatric cancer were analyzed by MFC vs. conventional diagnostic procedures. STOT was designed after several design–test–evaluate–redesign cycles based on a large panel of monoclonal antibody combinations tested on 301 samples. In its final version, STOT consists of a single 8-color/12-marker antibody combination (CD99-CD8/numyogenin/CD4-EpCAM/CD56/GD2/smCD3-CD19/cyCD3-CD271/CD45). Prospective validation of STOT in 149 samples showed concordant results with the patient WHO/ICCC-3 diagnosis in 138/149 cases (92.6%). These included: 63/63 (100%) reactive/disease-free samples, 43/44 (98%) malignant and 4/4 (100%) benign non-hematopoietic tumors together with 28/38 (74%) leukemia/lymphoma cases; the only exception was Hodgkin lymphoma that required additional markers to be stained. In addition, STOT allowed accurate discrimination among the four most common subtypes of malignant CD45− CD56++ non-hematopoietic solid tumors: 13/13 (GD2++ numyogenin− CD271−/+ nuMyoD1− CD99− EpCAM−) neuroblastoma samples, 5/5 (GD2− numyogenin++ CD271++ nuMyoD1++ CD99−/+ EpCAM−) rhabdomyosarcomas, 2/2 (GD2−/+ numyogenin− CD271+ nuMyoD1− CD99+ EpCAM−) Ewing sarcoma family of tumors, and 7/7 (GD2− numyogenin− CD271+ nuMyoD1− CD99− EpCAM+) Wilms tumors. In summary, here we designed and validated a new standardized antibody combination and MFC assay for diagnostic screening of pediatric solid tumors that might contribute to fast and accurate diagnostic orientation and classification of pediatric cancer in routine clinical practice.
Effect of Co-branding Strategy Elements on Consumer Attitude and Purchase Intention : A Study in Indonesia
Authors: Kania Rafiati , Sukoyo Kuntihapsari Sri , Wibisono Nono 
Published: October 2021

According to brand alliance literature, the compatibility of both brand characteristics in co-branded products will raise consumer positive attitude and purchase intention. Previous researches have explored co-branding strategy between the same sector or complement product character from different sector. However, few researchs have conducted exploration of the co-branding strategy in a different sector with less complement character. This study seeks to construct the value of co-branding strategy influencing female consumer attitude as well as purchase intention where the less-known Indonesian cosmetics brand who invite well-known food brands to create blended characteristics of cosmetic products. Three co-branded products namely Mizzu Cosmetics x Khong Guan Biscuits, Dear Me Beauty x Yupi, Dear Me Beauty x Sasa, Dear Me Beauty x Nissin as the object of research. A total of 358 questionnaires were distributed to female cosmetic consumers aged between 19-41. The proposed research model has been tested using PLS-SEM. The finding highlight prior attitude toward host brand appear weak to influence attitude toward co-branded. However, brand fit could mediate prior attitude toward host brand in influencing atittude toward co-branded. Mediating roles of brand fit, attitude toward co-brand, and post-attitude toward host brand appear important in the element of consumer attitude and purchase intention. A well-known and suitable co-branding partner is needed to give exposure to the co-branded product and provide a spill-over effect for the host brands. This study contribute to add spill-over effect phenomenon in brand alliance literatures.
Fano resonance of optical phonons in a multilayer graphene stack
Authors: Kitajima Masahiro , Katayama Ikufumi , Handegård Ørjan Sele , Nagao Tadaaki , Chiashi Shohei , Maruyama Shigeo , Takeda Jun 
Published: October 2021

Abstract
We studied Fano interference between the Raman spectrum of G-band phonons and electron continuum in a multilayer graphene stack. The thickness and power dependencies of the Fano interference coefficient ∣1/q∣ in the G-mode, where q is the Fano asymmetry parameter, were spatially visualized and analyzed using the Gaussian-convoluted Breit–Wigner–Fano function. The estimated ∣1/q∣ decreases with an increase in the layer number and laser power in the low-power region at least for monolayer, bilayer, and trilayer graphene. In the higher-power region, ∣1/q∣ increases with power only for monolayer graphene. The observed behaviors of ∣1/q∣ reflect the phase difference of Raman signals from the electron continuum and G-band and possibly originate from changes in the electronic relaxation time and the Fermi level of graphene owing to the laser heating of the sample.
ANALISIS KINERJA KEUANGAN PERHOTELAN AKIBAT PANDEMI COVID-19
Authors: Frihatni Andi Ayu , Sudirman Irmayanti , Mandacan Frengky 
Published: October 2021

Penelitian ini bertujuan untuk menganalisis dampak pandemi COVID-19 terhadap kinerja keuangan perhotelan sebelum dan selama pandemi COVID-19. Jenis penelitian ini adalah kuantitatif deskriptif yang dilakukan di Parepare Sulawesi Selatan. Sampel penelitian adalah seluruh hotel di Parepare sebanyak 25 hotel. Data laporan pendapatan dianalisis secara komparatif. Temuan hasil penelitian ini adalah adanya penurunan pendapatan hotel akibat pandemi COVID-19 yang berada di kisaran 13%-49%. Hasil penelitian ini berkontribusi terhadap dampak pandemi yang mempengaruhi sektor perhotelan di daerah. Ini menjadi bukti empiris bahwa kinerja keuangan sektor jasa perhotelan mengalami penurunan dibandingkan dengan tahun sebelumnya
Tindak Tutur Direktif Dalam Pidato Wakil Gubernur Nusa Tenggara Barat Dalam Penanganan Penyebaran Virus Korona-19
Authors: Lestari Sri Agustian , Sukri Sukri , Burhanuddin Burhanuddin 
Published: October 2021

Penelitian ini bertujuan untuk menjelaskan jenis tindak tutur direktif dan kecenderungan penggunaan jenis tindak tutur direktif dalam pidato wakil gubernur NTB terkait penanganan virus corona-19. Secara metodologis penelitian ini menggunakan metode simak, sedangkan analisis data menggunakan metode padan ekstralingual. Hasil penelitian ini terdapat 6 jenis tindak tutur direktif yaitu; tindak tutur direktif permintaan yang ditandai dengan kata minta, mari dan harapkan. Tindak tutur direktif bertanya ditandai dengan kata tanya bagaimana. Tindak tutur direktif perintah ditandai dengan kata tetap, ingat, partikel-lah, penggunaan tanda seru, dan kata harus. tindak tutur direktif larangan ditandai dengan kata jangan dan frase tidak boleh. Tindak tutur direktif pemberian izin ditandai dengan frase akan didenda. tindak tutur direktif nasehat ditandai dengan kata kalau, maka, jika, dan frase paling efektif, sangat penting. Keenam jenis tindak tutur direktif yang digunakan dalam pidato wakil gubernur NTB terkait penanganan virus covid-19 terdapat kecenderungan penggunaan tindak tutur direktif permintaan, perintah dan nasehat, akan tetapi yang paling dominan digunakan adalah tidak tutur direktif jenis nasehat.
Implementasi Program Pengembangan PAUD “Holistik Integratif’di PAUD LSM Ampenan Kota Mataram
Authors: Sugian Eni , Fahruddin Fahruddin , Witono A. Hari 
Published: October 2021

Penelitian ini bertujuan untuk memberikan deskripsi sejauh mana Implementasi Program PAUD Holistik Integratif di PAUD LSM Ampenan Kota Mataram yang mencakup perencanaan. Penelitian ini merupakan penelitian kualitatif. Teknik pengumpulan data menggunakan tekhnik wawancara, observasi dan dokumnetasi, subjek penelitian berjumlah 9 orang yang terdiri dari 1 orang kepala PAUD, 2 orang guru PAUD, 2 orang narasumber dari tenaga kesehatan dan tokoh masyarakat setempat dan 4 orang tua murid, dengan objek penelitian di PAUD LSM Ampenan Kota Mataram. Hasil penelitian ini menunjukan bahwa kepala lembaga PAUD LSM telah membuat program perencanaan sesuai dengan petunjuk teknis dan juknis penyelenggaraan program PAUD Holistik Integratif, berdasarkan hasil observasi, wawancara dan dokumentasi bahwa Kepala PAUD LSM telah membuat perencanaan yang di buktikan dengan adanya Dokumen program perencanaan PAUD holistic integrative yang memuat tujuan, proses, dan prinsip perencanaan yang di susun oleh Kepala lembaga dan guru PAUD LSM Ampenan.
A Quasi-experimental Study on the Impact of BlendedLearning on EFL Students’ Language Proficiency
Authors: BENHADJ Yassine 
Published: October 2021

The study aimed at examining the effect of adopting blended learning on Moroccan high school students’ English language proficiency. This has been essentially achieved through relying both on face-to-face classroom interactions and using “Google classroom”, which is a free online learning platform. The researcher opted for a quasi-experimental design to gauge the impact of implementing a blended learning model on the research sample. This study enlisted the participation of 79 Moroccan first-year Baccalaureate students who were divided into two separate but homogenous groups. The experimental group was taught using the blended learning model, and the control group was tutored in a traditional learning environment. The mean scores’ differences of the pre-test and the post-test asserted that, in comparison to the face-to-face learning, the blended learning model adopted was significantly impactful in improving the language proficiency level of the treatment group. However, no significant gender differences were observed in this regard. In essence, this piece of research has placed much emphasis on the idea that the efficient incorporation of ICT, particularly blended learning, into the learning/teaching process can help satisfy students’ needs, increase their motivation, and eventually enhance their language mastery.
Differential Diagnostics Focal Pancreatics Masses Based on the Analysis of the Echographic Texture of Endosonograms Using Fuzzy Mathematical Models
Authors: Belozerov V. A. , Ohotnikov O. I. , Korenevskij N. A. , Grigorev S. N. 
Published: October 2021

Relevance: Differential diagnosis of focal formations of the pancreas is particularly difficult due to the similarity of their echosemiotics. One of the ways to objectify and improve the accuracy of ultrasound data is to use artificial intelligence methods to interpret images.Purpose: Improving the quality of diagnosis of focal pancreatic pathology according to endoscopic ultrasonography based on the analysis of the echographic texture using fuzzy mathematical models.Material and methods: In the Kursk Regional Clinical Hospital, endoscopic ultrasonography was performed in 272 patients for pancreaticobiliary diseases. The endoscopic video system of the company Olympus EVIS EXERA II with the ultrasonic processor EU-ME1 was used. Solid tumors of the pancreas were detected in 109 (40.1 %) patients, focal pancreatic masses were diagnosed in 40 (14.7 %) patients. Based on the research results, the main types of reference endosonograms corresponding to differentiable pathology were identified. On the basis of endosonograms, using hybrid fuzzy mathematical decision rul, a fuzzy hybrid model of differential diagnosis of chronic focal pancreatitis and ductal adenocarcinoma of the pancreas was obtained.Results: The selected source of information and the method of synthesis of hybrid fuzzy decision rules made it possible to obtain a fuzzy hybrid model of differential diagnosis of chronic focal pancreatitis and ductal adenocarcinoma of the pancreas. Based on the results of mathematical modeling and statistical tests on representative control samples, it was shown that the resulting model of differential diagnosis, using reference endosonograms reflecting the echographic texture of focal pancreatic masses, provides confidence in the desired diagnosis at the level of 0.6. The additional information used in the analysis of endosonograms increases the diagnostic confidence to a value of 0.9.Conclusions: The resulting model of differential diagnosis of chronic focal pancreatitis and ductal adenocarcinoma of the pancreas provides confidence in decision-making no worse than 0.9, which is an acceptable quality indicator in clinical practice in conditions of insufficient statistics with poorly formalized data structure.
Differential Diagnosis of a Solitary Bone Lesion Using SPECT/CT Method
Authors: Ryzhkov A. D. , Krylov A. S. , Kaspshik S. M. , Bilik M. E. , Kochergina N. V. , Abdulova L. Y. , Bludov A. B. , Spirina O. G. 
Published: October 2021

Relevance: Radionuclide bone scan signs of lesions are not specific and require radiological identification. Hybrid tomographic technology is a combination of spatial distribution of radiopharmaceuticals and its anatomical binding. Thus, makes it possible to accurately identify the affected bone structure and also determine the nature of this changes (radiological anatomy). In cancer patients, SPECT/CT method allows to visualize tumor pathology in the bones, but also keeps to a minimum errors and other excessive examinations.Purpose: To demonstrate the most frequent diseases and conditions that simulate tumor lesions in bones on bone scan.Material and methods: We analyzed the results of examinations of 81 patients with various tumor diseases (2015–2020). Bone scan was performed in the whole body 3 hours later, after intravenous administration of 99mTc-phosphotech on a Symbia E, T2 (Siemens, Germany). SPECT/CT was performed after WB Bone Scan.Results: The most frequent reasons for the focal increased uptake of radiopharmaceutical were: reactive increase in metabolism and as a result additional mineral repair: deforming osteoarthritis, osteophytes; post‑traumatic and postoperative changes; fractures (osteoporosis and stress fractures); inflammatory processes; focal uptake due to the benign neoplasms of bones and dysplasia. Combination of highly sensitive but non-specific scintigraphy with highly specific computed tomography makes it especially useful in anatomically difficult areas.Conclusion: SPECT/CT reveals a direct pater of anatomical and structural abnormalities with changes in bone tissue metabolism in case of different injuries and minimizes a number of ambiguous conclusions. SPECT/CT in oncological practice greatly helps nuclear medicine physician in the differential diagnostic process and reduces time of examination for the patient.
TASKS TAKING INTO ACCOUNT THE PROFESSIONAL ORIENTATION WHEN CONSIDERING THE TOPIC «LAPLACE TRANSFORMATION» FOR STUDENTS OF THE TRAINING DIRECTION «13.03.02 - ELECTRIC POWER INDUSTRY AND ELECTRICAL ENGINEERING»
Authors: Жарикова Ольга Сергеевна , Зяблин Вячеслав Николаевич , Сорока Марина Владимировна , Столярова Валентина Вячеславовна 
Published: October 2021

Рассматривается специфика преподавания некоторых тем по дисциплине математика в контексте профессиональной направленности обучающихся.
The article considers the specifics of teaching some topics in the discipline of mathematics in the context of the professional orientation of students.
MOBILE APPLICATIONS FOR THE ANDROID OPERATING SYSTEM: DEVELOPMENT TECHNOLOGIES
Authors: Красноусов Виктор Михайлович , Букреев Леонид Вячеславович , Шпаковский Георигий Андреевивич , Калюжный Евгений Романович , Зариковская Наталья Вячеславовна 
Published: October 2021

В статье рассмотрены технологии, используемые для реализации мобильных приложений для платформы Android, на языке программирования Kotlin и архитектуры MVVM, а также реализации их серверной части на языке программирования Python.
The article discusses technologies for implementing an application for the Android platform in the Kotlin and MVVM programming languages, as well as the implementation of the server side in the Python programming language.