bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioactive compounds fromMatricaria chamomilla: structure identification,in vitroantiproliferative, antimigratory, antiangiogenic, and antiadenoviral activities
Authors: Shaaban Mohamed , El-Hagrassi Ali M. , Osman Abeer F. , Soltan Maha M. 
Published: August 2021

AbstractDuring our exploring the anticancer activity of some medicinal plants and their major metabolites, the aerial parts of the EgyptianMatricaria chamomilla(flowers and stems) were studied. GC–MS analysis of the organic soluble extracts of the flowers and stems fractions revealed the presence of 43 and 45 compounds, respectively. Individual chromatographic purification of the flowers and stems’ extracts afforded three major compounds. Structures of these compounds were identified by 1D- and 2D-NMR and HRESI-MS spectroscopic data as bisabolol oxide A (1) and (E)-tonghaosu (2) (as mixture of ratio 2:1) from the flowers extract, meanwhile apigenin-7-β-d-glucoside(3)from the stems fraction. Biologically, the chamomile extracts announced significant antiproliferative activities exceeded in potency by ∼1.5 fold in case of the stem, recording GI5013.16 and 17.04 μg/mL against Caco-2 and MCF-7, respectively. Both fractions were approximately equipotent against the migration of the same cell type down to 10 μg/mL together, compounds1,2but not3, showed considerable growth inhibition of the same cells at GI5013.36 and 11.83 μg/mL, respectively. Interestingly, they were able to suppress Caco-2 colon cancer cells migration at 5.8 μg/mL and potently inactivate the VEGFR2 angiogenic enzyme (1.5-fold relative to sorafenib. The obtained compounds and corresponding chamomile extracts were evaluated against Adeno-7 virus, revealing that both chamomiles’ extracts (flowers and stems) and their corresponding obtained compounds (1–3) were potent in their depletion to the Adeno 7 infectivity titer, however, the flower extract and compounds1–2were more effective than those of the stem extract and its end-product (3).
THE INFLUENCE OF DELAY FACTORS ON PAHANG MALAYSIAN CONSTRUCTION INDUSTRY: A PLS-SEM APPROACH
Authors: Adeleke Adekunle Qudus , Adeniyi Ajibike Waliu , Muuka Gerry Nkombo 
Published: August 2021

Previous research has shown that delay is a common problem in construction industry. Weather condition and regulation changes, though being minor factors, are also known as external factors contributing to the delay of project construction. This study involved 118 respondents from the construction industry in Kuantan, Pahang. In order to obtain the data, copies of questionnaire were distributed widely among people in Pahang construction industry. The data were analysed by using Partial Least Squares Structural Equation Modelling version 3. A significant positive relationship between weather conditions and building projects in Pahang construction industry was identified. This study also found a negative relationship between regulation changes and building projects in Pahang construction industry. As expected, weather conditions were found to be one of the factors contributing to delay in the process of projects’ construction in Malaysia. However, weather conditions and the regulation changes did not significantly affect the construction projects in Malaysia. Out of the factors which contributed to delay in building projects, weather conditions, though a minor factor, played to an extent a part in contributing to extension of the time of the projects in Malaysia. Nevertheless, regulation changes was not considered a vital factor leading to delay in building projects in Malaysia.
Adeziv Sistemlerin ve Kompozit Rezin Materyallerin Derin Dentine Bağlanma Dayanımlarının İncelenmesi: in vitro çalışma
Authors: GÜRSES Merve , TAĞTEKİN Dilek , YANİKOGLU Funda 
Published: August 2021

Amaç: Bu çalışmanın amacı, düz dentin yüzeylerinde 2 farklı adeziv sistemin ve 3 farklı kompozit rezinin dentine mikrogerilim bağlanma kuvvetinin (µTBS) belirlenmesi ve bağlanma dayanımı üzerine etkisinin incelenmesidir.
Gereç ve Yöntemler: 24 adet insan 3. büyük azı dişinde düz derin dentin yüzeyleri hazırlanmıştır. Dişler rastgele seçilerek, Self-etch (Futurabond M SingleDose VOCO) ve Total-etch (37% fosforik asit Condac 37, Adeziv 200T 3M) olmak üzere iki gruba ayrılmıştır. Gruplar 3’er alt gruba ayrılmak üzere, 3 farklı kompozit rezin (X-tra Fill VOCO, SonicFill Kerr, Grandio VOCO) uygulanarak restore edilmiştir. Tüm dişlerin merkezinden 6’şar adet çubuk şeklinde numune elde edilmiştir. Tüm numunelere mikrogerilim testi uygulanmıştır. İstatistiksel analiz testleri Sigmaplot 12.5 paket programında gerçekleştirilmiştir. Kruskal-Wallis ve Tukey testleri kullanılmıştır.Bulgular: Grupların median değerleri arasında istatistiksel olarak anlamlı bir farklılık olduğu görülmüştür (p=0,010). Tukey testinin sonuçlarına göre (p0.05).
Sonuç: Dentine bağlanma dayanımlarında adeziv sistemler arasında fark görülmezken; geleneksel incremental kompozit, Bulk-fill kompozitlerden daha başarılı bulunmuştur.
Effect of Mouthwashes on Color Stability of Artificial Gingival Materials Used in Implant Retained Hybrid Prostheses
Authors: BOZOĞULLARI Hatice Nalan , ÇITIR YÜCEL Hande 
Published: August 2021

Background: The aim of this in vitro study was to investigate the effect of different mouthwashes on the color stability of artificial gingiva material that are used in implant retained hybrid prostheses.
Material and Methods: The materials examined in terms of color stability are the gingival colored composite (Gradia Plus Gum, GC Europe,Belgium), pink heat polymerised acrylic resin (Meliodent, Heraeus Kulzer, Germany) and pink feldspathic porcelain (EX-3 Super Porcelain,Noritake,Kuraray, Japan). Forty disc-shaped (10×2 mm) samples were prepared according to the manufacturer's instructions (N=120). Samples of each material were divided into four subgroups (n=10) which immersed in three different mouthwash agents and distilled water (control group) for 14 days, at 37° C. Color parameters were measured with a colorimeter (Konica Minolta CR- 321, Tokyo, Japan) before and after immersion and color differences were calculated according to the CIEDE2000 (ΔE00) formula. The data were statistically analyzed with two-way analysis of variance (ANOVA) and Post Hoc Bonferroni tests (p
Application of Titanium Dioxide for Zirconium Ions Adsorption and Separation from a Multicomponent Mixture
Authors: Vasylyeva H. , Mironyuk I. , Mykytyn I. , Strilchuk M. , Maliuk I. , Tryshyn V. , Savka Kh. 
Published: August 2021

This work studies the adsorption of zirconium ions by mesoporous titanium dioxide and by sodium-modified mesoporous titanium dioxide. Experimental maximal adsorption values of zirconium ions by H-TiO2 and Na-TiO2 were found to be 64 mg/g and 109,5 mg/g respectively. This process depends on the interaction time, equilibrium concentration of zirconium ions and acidity of the solution. Adsorption kinetics fit well into the diffusion kinetic model and indicate a several stages of zirconium ions adsorption. Equilibrium adsorption of zirconium ions is well described by the Langmuir's adsorption theory for both adsorbents. The results obtained by inductively coupled plasma mass spectrometry showed that the investigated adsorbent selectively adsorb zirconium ions from the mixture with strontium and yttrium ions in the range of solution pH = 0-1. The percentage of maximum extraction of zirconium ions is 86,61% for H-TiO2 and 94,11% for Na-TiO2. This fact is extremely valuable for nuclear forensics or for the determination of 90Sr in low activity background samples.
Krónikus aortadissectio talaján kialakult thoracoabdominalis aneurysma endovascularis kezelése fenesztrált sztentgrafttal
Authors: Csobay-Novák Csaba , Entz László , Banga Péter , Pólos Miklós , Szabolcs Zoltán , Csikós Gergely , Fontanini Daniele Mariastefano , Vecsey-Nagy Milán , Szeberin Zoltán 
Published: August 2021

Összefoglaló. Az aortadissectio krónikus stádiumában kialakuló
thoracoabdominalis tágulatok megoldása multidiszciplináris megközelítést, nagy
felkészültséget és fejlett technológiát igényel. A jellemzően többlépcsős
műtétsorozat mortalitása és morbiditása az endovascularis technológia
fejlődésével csökkent, de még mindig jelentős. A fenesztrált endovascularis
aortaműtét a thoracoabdominalis nyitott műtét alternatívája, mely kisebb
mortalitással és morbiditással, rövidebb kórházi tartózkodással jár.
Aortadissectio esetén történő alkalmazása az aorta lumenében lévő membrán miatt
kihívást jelent. Esetbemutatásunkban egy 56 éves nőbeteget demonstrálunk, aki
tíz évvel korábban A-típusú dissectio miatt aorta ascendens rekonstrukción esett
át. A követés során csaknem a teljes aorta tágulata alakult ki, melynek
megoldása három lépésben történt. Az első lépésben a disszekált aortaív nyitott
műtétjét végeztük ’frozen elephant trunk’ technikával, majd az aorta descendens
tágulatának endovascularis kezelése történt sztentgraft-implantációval. A
műtétsorozat záró lépése egy fenesztrált endovascularis aortaműtét volt, mely
egyben ezen technikának az aortadissectio esetében történt első hazai
alkalmazását jelenti. Orv Hetil. 2021; 162(31): 1260–1264.
Summary. Thoracoabdominal aortic aneurysms developing in the chronic
phase of an aortic dissection require multidisciplinary approach, experienced
operators and advanced technology. The mortality and morbidity rate of these
multistage operations were reduced with the latest technical achievements in
endovascular repair, but they are still significant. Fenestrated endovascular
aortic repair, an alternative of thoracoabdominal open repair, is associated
with less mortality and morbidity, shorter hospital stay. Using fenestrated
devices in aortic dissection is usually technically demanding due to the
dissection membrane. We report the case of a 56-year-old woman, who underwent
ascending aortic repair due to type A aortic dissection. During the follow-up, a
large thoracoabdominal aneurysm developed involving also the arch. We performed
a three-stage operation starting with the open repair of the aortic arch using a
‘frozen elephant trunk’ device followed by a thoracic endovascular aortic repair
of the descending aorta. The final stage was a fenestrated endovascular aortic
repair, which is the first use of this technique in aortic dissection in
Hungary. Orv Hetil. 2021; 162(31): 1260–1264.
EKG-gyöngyszem: akut coronaria szindróma gyanúját keltő EKG-műtermék – poroszsisak-jel
Authors: Tomcsányi János 
Published: August 2021

Összefoglaló. Egy 47 éves nőbeteg tranziens ST-eleváció miatt került
felvételre és coronarographiára. A tranziens ST-elevációnak véleményezett
elektrokardiogram poroszsisak-jelnek felelt meg, amelyet egy EKG-műtermék
okozott. Habár a poroszsisak-jelnek számtalan, nem coronariaeredetű oka ismert,
műtermék okozta poroszsisak-jelet még nem ismertettek. Fontos a felismerése a
felesleges diagnosztikai és terápiás beavatkozások elkerülése céljából. Orv
Hetil. 2021; 162(34): 1383–1385.
Summary. A 47-year-old female patient was admitted for coronary
angiography due to transient ST elevation. The electrocardiogram rated for
transient ST elevation corresponded to a spiked helmet sign caused by an ECG
artifact. Although a number of non-coronary causes of the spiked helmet sign are
known, not one caused by a computer artifact has been reported yet. It is
important to recognize it to avoid unnecessary diagnostic and therapeutic
interventions. Orv Hetil. 2021; 162(34): 1383–1385.
POLİSİTEMİA VERA OLGULARINDA JAK2 V617F MUTASYON SIKLIĞI VE LABORATUVAR BULGULARI İLE İLİŞKİSİ
Authors: HEKİMLER ÖZTÜRK Kuyaş , TEPEBAŞI Muhammet Yusuf , ÖZBAŞ Halil , KOŞAR Pınar 
Published: August 2021

Amaç
Polisitemia vera (PV) miyeloid hücrelerin klonal proliferasyonu
ile karakterize klonal bir hastalıktır. Janus
tirozin kinaz 2 (JAK2) geni V617F mutasyonunun hastalığın
moleküler patogenezinin temelini oluşturduğu
gösterilmiştir. Bu çalışmada PV’lı hastalarda JAK2
V617F mutasyon sıklığı ve hematolojik parametreler
ile arasındaki ilişkinin incelenmesi amaçlanmıştır.
Gereç ve Yöntem
Bu retrospektif kohort çalışmasına BCR-ABL negatif
PV tanılı 18’i kadın, 60'ı erkek olmak üzere toplam 78
hasta dahil edildi. Hastalara ait poliklinik dosyaları incelenerek
demografik özellikler, laboratuvar bulguları
ve JAK2 V617F mutasyon analiz sonuçları kaydedildi.
JAK2 V617F mutasyon analizleri Real-Time PCR
yöntemi ile yapıldı.
Bulgular
Çalışmaya dahil edilen 78 PV hastasının 21’inde
(%26,9) JAK2 V617F mutasyonu saptandı. Mutasyon
varlığı ve cinsiyet arasında fark saptanmadı (p>0.05).
Mutasyon pozitifliğine göre yapılan gruplandırmada
JAK2 V617F mutasyonu taşıyan hastalarda yaş, RBC,
RDW ve PLT seviyeleri açısından anlamlı derecede
yüksek saptanırken (sırasıyla, p=0,000; p=0,030;
p=0,028; p=0,029), serum demir düzeyi açısından
anlamlı derecede düşük saptandı (p=0,036) . WBC,
HB ve HCT seviyeleri her iki grupta benzerdi (p>0,05).
Sonuç
Mutasyonun prognostik değerini ve klinik ve laboratuvar
değişkenleriyle ilişkisini göstermek için daha kapsamlı
prospektif çalışmalara ihtiyaç vardır.
Aproximación al impacto socio-económico de la obra “El Alcalde de Zalamea”
Authors: Marcelo Marcelo Sánchez-Oro Sánchez 
Published: August 2021

La interpretación popular de la obra de teatro de “El Alcalde de Zalamea”, en el pueblo extremeño de Zalamea de la Serena, es una actividad socio-cultural que implica a todo el pueblo desde hace años. Centrado en la obra teatral de Calderón de la Barca, en este artículo se hace una aproximación descriptiva al impacto de esta teatralización popular en la localidad y los efectos que esto tiene para el turismo y para el desarrollo local.
El artículo se deriva de una Trabajo Fin de Grado del Grado de ADE de la Universidad de Extremadura, elaborado por Cristina Algaba Benítez y dirigido por el profesor Marcelo Sánchez-Oro Sánchez.
Palabras claves: Turismo, cultura, eventos.
FREQUENCY FOLLOWING RESPONSES IN VOCALISTS, VIOLINISTS, AND NONMUSICIANS TO CARNATIC MUSICAL STIMULI
Authors: Bhat Prajna , K Rajalakshmi 
Published: August 2021

BackgroundThe current study investigates pitch coding among vocalists, violinists, and non-musicians to Carnatic musical stimuli.Material and methodsThree groups of participants were included in the study: 10 trained Carnatic vocalists, 10 violinists,and 10 non-musicians. Their ages ranged from 18 to 45 years. Two types of stimuli were given: three notes of a Carnatic raga (S R2 G3) sung by a trained vocalist and three notes of a Carnatic raga (S R2 G3) played on violin by a trained violinist. Frequency following responses (FFRs) were recorded binaurally at 80 dBSPL for both stimuli using Neuroscan equipment.ResultsGrand average responses of all participants were generated. To assess a participant’s pitch tracking to the Carnatic music stimuli, stimulus-to-response correlation, pitch strength, and pitch error were calculated. Vocalists and violinists had better stimulus-to-response correlation and pitch strength values with lower pitch error values than non-musicians for both vocal and violin stimuli. Within both the vocalist and violinist groups, superior performance was noticed for the vocal stimulus compared to the violin stimulus. No such preference was evident among non-musicians.ConclusionsClassical music training dependent plasticity can be demonstrated at brainstem level itself. This holds true for both vocal and violin music, a finding not reported previously. Further a link between musical training and the FFR response can be more strongly demonstrated for vocalists than for violinists.
SENSE OF COHERENCE AND TINNITUS ANNOYANCE IN ADULTS
Authors: Paluchowska Justyna , Fludra Małgorzata , Kobosko Joanna , Gos Elżbieta , Skarżyński Henryk 
Published: August 2021

BackgroundTinnitus is usually a chronic (ongoing) condition which in many cases significantly impairs the affected person’s quality of life. Their habituation to tinnitus depends on the patient’s personality resources. The aim of this research was to determine if a particular psychological meta-resource, in this case a sense of coherence, is related to the perceived annoyance of tinnitus.Material and methodsThe study included 176 people (123 females, 53 males) aged 31–80 (M = 59.1) diagnosed with tinnitus. To measure the sense of coherence, we used the Sense of Coherence Questionnaire (SOC 29), and to evaluate the tinnitus annoyance, we used the Tinnitus Handicap Inventory (THI). The subjects also filled in a survey to capture sociodemographic data and their medical history.ResultsThe sense of coherence (in total and in particular aspects) turned out to be significantly correlated with tinnitus annoyance (in total and in particular aspects). The overall level of coherence turned out to be an essential predictor for the overall level of tinnitus annoyance. The degree of manageability was a particularly important component of the sense of coherence which affected tinnitus annoyance.ConclusionsIn people with a strong sense of coherence, especially with a strong manageability component, there is a lower level of tinnitus annoyance. Psychological interventions – counselling, psychoeducation, psychotherapy – support the development of a sense of coherence and can reduce tinnitus annoyance.
CERVICAL AND OCULAR VESTIBULAR EVOKED MYOGENIC POTENTIALS IN MIGRAINE PATIENTS
Authors: Dabbous Abeir , Shalaby Nevin , Abousetta Alaa El-Din , Hosny Noha , Fadel Eman 
Published: August 2021

BackgroundIn migraine, there is no anatomical correlate of vertigo and no structural abnormality is evident in conventional imaging. Cervical vestibular-evoked myogenic potential (cVEMP) is an uncrossed inhibitory vestibulo-spinal reflex (VSR), while ocular VEMP (oVEMP) represents a crossed excitatory vestibulo-ocular reflex (VOR).ObjectiveThis study aims at functional evaluation of the findings of cVEMP and oVEMP in migraine patients.Material and methodsThis was a cross-sectional case-control study that included 20 migraine patients as the case group and 30 healthy adult subjects as a control group. All participants were subjected to history taking, otological examination, basic audiological evaluation, bedside examination of the dizzy patient, cVEMP, oVEMP, and posturography tests.Results35% of migraine patients showed delayed cVEMP latency and 40% showed abnormal oVEMP in the form of statistically significant delayed right oVEMP P1 (p = 0.050) and left oVEMP N1 latency (p = 0.038) compared with controls. cVEMP parameters were not correlated to posturography results. The majority of migraine patients (70%) had normal equilibrium pattern and normal sensory analyses ratios (65%). Only 30% had vestibular dysfunction.ConclusionsVSR and VOR are affected in migraine patients. We recommend the use of cVEMP and oVEMP in migraine patients for functional assessment of brainstem pathways.
Multicycle Simulation of Strike-Slip Earthquake Rupture for Use in Near-Source Ground-Motion Simulations
Authors: Galvez Percy , Petukhin Anatoly , Somerville Paul , Ampuero Jean-Paul , Miyakoshi Ken , Peter Daniel , Irikura Kojiro 
Published: August 2021

ABSTRACTRealistic dynamic rupture modeling validated by observed earthquakes is necessary for estimating parameters that are poorly resolved by seismic source inversion, such as stress drop, rupture velocity, and slip rate function. Source inversions using forward dynamic modeling are increasingly used to obtain earthquake rupture models. In this study, to generate a large number of physically self-consistent rupture models, rupture process of which is consistent with the spatiotemporal heterogeneity of stress produced by previous earthquakes on the same fault, we use multicycle simulations under the rate and state (RS) friction law.We adopt a one-way coupling from multicycle simulations to dynamic rupture simulations; the quasidynamic solver QDYN is used to nucleate the seismic events and the spectral element dynamic solver SPECFEM3D to resolve their rupture process. To simulate realistic seismicity, with a wide range of magnitudes and irregular recurrence, several realizations of 2D-correlated heterogeneous random distributions of characteristic weakening distance (Dc) in RS friction are tested. Other important parameters are the normal stress, which controls the stress drop and rupture velocity during an earthquake, and the maximum value of Dc, which controls rupture velocity but not stress drop. We perform a parametric study on a vertical planar fault and generate a set of a hundred spontaneous rupture models in a wide magnitude range (Mw 5.5–7.4).We validate the rupture models by comparison of source scaling, ground motion (GM), and surface slip properties to observations. We compare the source-scaling relations between rupture area, average slip, and seismic moment of the modeled events with empirical ones derived from source inversions. Near-fault GMs are computed from the source models. Their peak ground velocities and peak ground accelerations agree well with the ground-motion prediction equation values. We also obtain good agreement of the surface fault displacements with observed values.
TÜRKİYE’DE KUR REJİMLERİ VE EKONOMİK BÜYÜME İLİŞKİSİ: KALMAN FİLTRESİ İLE BİR UYGULAMA
Authors: KOÇ Ümit 
Published: August 2021

Küreselleşmenin reel ve finansal sektörler üzerindeki etkisine paralel olarak hem ürün tedarik
zincirleri hem de finansal piyasalar dünya ölçeğinde büyük bir hızla entegre olmaktadır. Bu entegrasyon
ile birlikte uluslararası ticaret ve portföy yatırımları bağlamında döviz kuru tüm ülkeler için daha da
önemli hale gelmektedir. 1970’li yılların sonundan itibaren sabit kur rejimleri terkedilmeye başlanmış
ve esnek kur rejimlerine geçiş sağlanmıştır. Bu çalışmadaki amacımız, 1960 - 2019 zaman aralığında
kur rejimleri ile büyüme arasındaki ilişkiyi araştırmak ve bir model üzerinden Türkiye örneğini
incelemektir. Kullanılan modelde Kalman filtresi uygulanmakta ve zaman içinde değişen katsayıların
izlediği patika gözlemlenmektedir. Çalışmada katsayıların zaman içinde aldıkları değerler, sabit ve
yönetilen kur rejimlerinin ekonomik büyüme üzerinde belirgin bir etkisinin olmadığı, esnek kur
rejimlerinin ise ekonomik büyümeyi negatif etkilediği sonuçlarına işaret etmektedir.
The Effect of Implementation of Management Support Work Environment, Team Work, and Employee Development to Employee Engagement with Employee Motivation as Mediating Variable
Authors: Nelson Alden 
Published: August 2021

Employee engagement is essential for the company's long-term growth and increased profits in an increasingly competitive industry. This study aims to analyze the effect of implementing a management support, work environment, team work, employee development to employee engagement. The research conducted in manufacturing companies in Batam with 396 respondents. The data test using SPSS and Smart PLS. The results of the study explained the direct effect variable has significant effect and variable teamwork has very significant effect compare to other independent variables. Indirect influence explains that team work have a significant effect to employee engagement through employee motivation but management support does not significantly influence employee engagement through employee motivation.