bluuebunny/crossref_metadata_2025_split huggingface dataset:
FLIM as a Promising Tool for Cancer Diagnosis and Treatment Monitoring
Authors: Ouyang Yuzhen , Liu Yanping , Wang Zhiming M. , Liu Zongwen , Wu Minghua 
Published: June 2021

AbstractFluorescence lifetime imaging microscopy (FLIM) has been rapidly developed over the past 30 years and widely applied in biomedical engineering. Recent progress in fluorophore-dyed probe design has widened the application prospects of fluorescence. Because fluorescence lifetime is sensitive to microenvironments and molecule alterations, FLIM is promising for the detection of pathological conditions. Current cancer-related FLIM applications can be divided into three main categories: (i) FLIM with autofluorescence molecules in or out of a cell, especially with reduced form of nicotinamide adenine dinucleotide, and flavin adenine dinucleotide for cellular metabolism research; (ii) FLIM with Förster resonance energy transfer for monitoring protein interactions; and (iii) FLIM with fluorophore-dyed probes for specific aberration detection. Advancements in nanomaterial production and efficient calculation systems, as well as novel cancer biomarker discoveries, have promoted FLIM optimization, offering more opportunities for medical research and applications to cancer diagnosis and treatment monitoring. This review summarizes cutting-edge researches from 2015 to 2020 on cancer-related FLIM applications and the potential of FLIM for future cancer diagnosis methods and anti-cancer therapy development. We also highlight current challenges and provide perspectives for further investigation.
Deep learning of total electron content
Authors: Sorkhabi Omid Memarian 
Published: June 2021

AbstractOne of the most notable errors in the global navigation satellite system (GNSS) is the ionospheric delay due to the total electron content (TEC). TEC is the number of electrons in the ionosphere in the signal path from the satellite to the receiver, which fluctuates with time and location. This error is one of the major problems in single-frequency (SF) GPS receivers. One way to eliminate this error is to use dual-frequency. Users of SF receivers should either use estimation models or local models to reduce this error. In this study, deep learning of artificial neural networks (ANN) was used to estimate TEC for SF users. For this purpose, the ionosphere as a single-layer model (assuming that all free electrons in the ionosphere are in this thin layer) is locally modeled by the code observation method. Linear combination has been used by selecting 24 permanent GNSS stations in the northwest of Iran. TEC was modeled independently of the geometry between the satellite and the receiver, called L4. This modeling was used to train the error ANN with two 5-day periods of high and low solar and geomagnetic activity range with a hyperbolic tangential sigmoid activation function. The results show that the proposed method is capable of eliminating ionosphere error with an average accuracy of 90%. The international reference ionosphere 2016 (IRI2016) is used for the verification, which has a 96% significance correlation with estimated TEC.
Capturing the Development of Internal Representations in a High-Performing Deep Network for Sleep Stage Classification
Authors: Paisarnsrisomsuk Sarun , Ruiz Carolina , Alvarez Sergio A. 
Published: June 2021

AbstractDeep neural networks can provide accurate automated classification of human sleep signals into sleep stages that enables more effective diagnosis and treatment of sleep disorders. We develop a deep convolutional neural network (CNN) that attains state-of-the-art sleep stage classification performance on input data consisting of human sleep EEG and EOG signals. Nested cross-validation is used for optimal model selection and reliable estimation of out-of-sample classification performance. The resulting network attains a classification accuracy of $$84.50 \pm 0.13\%$$

84.50
±
0.13
%

; its performance exceeds human expert inter-scorer agreement, even on single-channel EEG input data, therefore providing more objective and consistent labeling than human experts demonstrate as a group. We focus on analyzing the learned internal data representations of our network, with the aim of understanding the development of class differentiation ability across the layers of processing units, as a function of layer depth. We approach this problem visually, using t-Stochastic Neighbor Embedding (t-SNE), and propose a pooling variant of Centered Kernel Alignment (CKA) that provides an objective quantitative measure of the development of sleep stage specialization and differentiation with layer depth. The results reveal a monotonic progression of both of these sleep stage modeling abilities as layer depth increases.
Implementing Industrial Symbiosis Incentives: an Applied Assessment Framework for Risk Mitigation
Authors: Henriques Juan Diego , Azevedo João , Dias Rui , Estrela Marco , Ascenço Cristina , Vladimirova Doroteya , Miller Karen 
Published: June 2021

AbstractIndustrial symbiosis (IS) is a business model that proposes symbiotic exchanges, allowing the flow of resources, wastes, and utilities between companies. In recent years, IS initiatives have been exponentially growing around the world. This can be attributed to the increasing awareness on the possibility of obtaining economic, environmental, and social benefits through the implementation of this model. Despite the exponential growth of IS initiatives, the companies are still facing problems in the achievement of reliable and permanent synergies. Over the years the literature has identified several factors in the IS emerging process. Incentives are among these factors, being defined as unlocking tools or mechanisms related to diverse dimensions such as economic, political, social, intermediaries, process, and technology. Authors believe that the large-scale implementation of IS incentives has not been properly addressed. In order to promote facilitated IS implementation and achieve a replicator effect, incentives should be fully addressed. In many case studies, it has been observed that the incentives for IS can be threatened by risks, compromising the implementation, and hindering the emerging process. This study developed a dedicated framework that is composed of incentive identification from best practices of IS and expert consultation; a risk assessment model based on risk factors identification and clustering; and finally, the mitigation actions based on the assessment outputs. The main result of this study is one set of mitigations actions that correlate the implementation levels (clusters) and the potential stakeholders involved.
Cash incentives for weight loss work only for males
Authors: Yeung Catherine , Ho Teck-Hua , Sato Ryoko , Lim Noah , Van Dam Rob M. , Tan Hong-Chang , Tham Kwang-Wei , Ali Rehan 
Published: June 2021

AbstractWhen governments and healthcare providers offer people cash rewards for weight loss, an assumption is that cash rewards are versatile, working equally well for everyone – for example, for all genders. No research to date has tested for gender difference in response to financial incentives for weight loss. We show in an randomized controlled trial (RCT) (n = 472) that cash incentives for weight loss only worked for males. The RCT consisted of a 3-month, self-administered online weight loss program. Offering a US$150 incentive for a 5% weight loss more than tripled the proportion of males who were successful, compared with a no-incentive Control arm (20.9% vs. 5.9%). On average, males in the incentive arm lost 2.4% of weight over 3 months, compared with 0.9% in the Control arm. The same incentive had no such effect on females: The average weight loss in the incentive arm was not significantly different than in the Control (1.03% and 1.44%, respectively), nor was the proportion of participants meeting the 5% weight loss goal (8.6% and 8.7%, respectively). This study shows that males respond better than females to financial incentives for weight loss.
Changes in the number of intensive care unit beds in US hospitals during the early months of the coronavirus disease 2019 (COVID-19) pandemic
Authors: Weiner-Lastinger Lindsey M. , Dudeck Margaret A. , Allen-Bridson Katherine , Dantes Raymund , Gross Cindy , Nkwata Allan , Tejedor Sheri Chernetsky , Pollock Daniel , Benin Andrea 
Published: June 2021

AbstractUsing data from the National Healthcare Safety Network (NHSN), we assessed changes to intensive care unit (ICU) bed capacity during the early months of the COVID-19 pandemic. Changes in capacity varied by hospital type and size. ICU beds increased by 36%, highlighting the pressure placed on hospitals during the pandemic.
Nationalism and Religion in Comparative Perspective: A New Typology of National-Religious Configurations
Authors: Aktürk Şener 
Published: June 2021

AbstractDoes religion motivate and intensify nationalism, or does religion moderate and even suppress nationalism? Six kinds of relationships between nationalism and religion are critically reviewed: nationalism as a modern religion in competition with traditional religions; religious origins of the “Chosen People” as the mythomoteur of nationalism; religious exclusion as nation-building; religious influences on national policies; influence of religious observance on national identification; and religiously based “civilizations” transcending nationalisms. Western Christian experience with nationalism is not generalizable due to the institutional autonomy and supranational organization of the Catholic Church. Western European nationalisms were premised on religious sectarian homogeneity, and the homogenous “confessional state” served as the template of European nation-states. Furthermore, I argue that the late medieval eradication of Muslims and Jews across Western Europe prefigured sectarian and ethnonational purges of the following centuries. Finally, I argue that different configurations of religion and nationalism depend on two critical conditions: the degree to which the dominant religious tradition is doctrinally supraethnic and institutionally transnational, and the religious identity of the main adversary in the constitutive conflict that culminated in national statehood. The crises of Marxism and liberalism provide the context for the resurgence of religion and nationalism at present.
Iron-biofortified pearl millet consumption increases physical activity in Indian adolescent schoolchildren after a 6-month randomised feeding trial
Authors: Pompano Laura M. , Luna Sarah V. , Udipi Shobha A. , Ghugre Padmini S. , Przybyszewski Eric M. , Haas Jere 
Published: June 2021

AbstractFe deficiency has negative effects on voluntary physical activity (PA); however, the impact of consuming Fe-biofortified staple foods on voluntary PA remains unclear. This study compared the effects of consuming Fe-biofortified pearl millet or a conventional pearl millet on measures of voluntary PA in Indian schoolchildren (ages 12–16 years) during a 6-month randomised controlled feeding trial. PA data were collected from 130 children using Actigraph GT3X accelerometers for 6 d at baseline and endline. Minutes spent in light and in moderate-to-vigorous PA were calculated from accelerometer counts using Crouter’s refined two-regression model for children. Mixed regression models adjusting for covariates were used to assess relationships between intervention treatment or change in Fe status and PA. Children who consumed Fe-biofortified pearl millet performed 22·3 (95 % CI 1·8, 42·8,P= 0·034) more minutes of light PA each day compared with conventional pearl millet. There was no effect of treatment on moderate-to-vigorous PA. The amount of Fe consumed from pearl millet was related to minutes spent in light PA (estimate 3·4 min/mg Fe (95 % CI 0·3, 6·5,P= 0·031)) and inversely related to daily sedentary minutes (estimate −5·4 min/mg Fe (95 % CI –9·9, −0·9,P= 0·020)). Consuming Fe-biofortified pearl millet increased light PA and decreased sedentary time in Indian schoolchildren in a dose-dependent manner.
Association of blood lead level with vitamin D binding protein, total and free 25-hydroxyvitamin D levels in middle-school children
Authors: Rahman Abdur , Al-Sabah Reem , Jallad Reem , Rao Muddanna S. 
Published: June 2021

AbstractA negative association between blood Pb level (BPbL) and vitamin D metabolites in occupationally exposed populations has been reported, but data from the general population are scarce. Furthermore, the association between BPbL and vitamin D binding protein (DBP) and free 25-hydroxyvitamin D (25(OH)D) has not been reported. We investigated the association of BPbL with DBP, total and free 25(OH)D in healthy adolescents (n 1347; age range 11–16 years) cross-sectionally selected from all Governorates of Kuwait, utilising multi-stage cluster random sampling. Pb in whole blood was analysed by inductively coupled plasma MS, and DBP with ELISA. Plasma 25(OH)D was analysed by LC-MS/MS, and free 25(OH)D was calculated utilising the levels and binding affinities of DBP and albumin for 25(OH)D. DBP was positively associated with BPbL (β = 0·81; 95 % CI 0·14, 0·22; P < 0·001). A negative association between BPbL and total 25(OH)D was non-significant (P = 0·24) when BPbL was used as a continuous variable but was significant when used as quartiles (P = 0·02). The negative association between BPbL and free 25(OH)D was significant whether BPbL was used as continuous, as quartiles or as cut-off point of <5 µg/dl (0·24 µmol/l). In multinomial logistic regression, the odds of vitamin D insufficiency and deficiency were more than two-fold higher in the upper quartiles of BPbL compared with the lowest quartile. The negative correlation of BPbL with free 25(OH)D was more robust than its correlation with total 25(OH)D. Future studies must consider the levels of DBP when assessing the association between Pb and vitamin D metabolites.
Nutrition and indoor cycling: a cross-sectional analysis of carbohydrate intake for online racing and training
Authors: King Andy J. , Hall Rebecca C. 
Published: June 2021

AbstractCycling is a sport characterised by high training load, and adequate nutrition is essential for training and race performance. With the increased popularity of indoor trainers, cyclists have a unique opportunity to practice and implement key nutritional strategies. This study aimed to assess carbohydrate (CHO) intake of cyclists training or racing in this unique scenario for optimising exercise nutrition. A mixed-methods approach consisting of a multiple-pass self-report food recall and questionnaire was used to determine total CHO intake pre, during and post-training or racing using a stationary trainer and compared with current guidelines for endurance exercise. Sub-analyses were also made for higher ability cyclists (>4 W/kg functional threshold power), races v. non-races and ‘key’ training sessions. Mean CHO intake pre and post-ride was 0·7 (sd 0·6) and 1·0 (sd 0·8) g kg/BM and 39·3 (sd 27·5) g/h during training. CHO intake was not different for races (pre/during/post, P = 0·31, 0·23, 0·18, respectively), ‘key sessions’ (P = 0·26, 0·89, 0·98) or higher ability cyclists (P = 0·26, 0·76, 0·45). The total proportion of cyclists who failed to meet CHO recommendations was higher than those who met guidelines (pre = 79 %, during = 86 %, post = 89 %). Cyclists training or racing indoors do not meet current CHO recommendations for cycling performance. Due to the short and frequently high-intensity nature of some sessions, opportunity for during exercise feeding may be limited or unnecessary.
Between Populism and Juristocracy: The Republicanism of Rainer Knopff
Authors: Sigalet Geoffrey 
Published: June 2021

AbstractRainer Knopff's scholarship on Canadian constitutionalism has offered some of the most trenchant criticism of the exercise of judicial review under the Charter, yet his theory has largely been misunderstood (as has that of his frequent co-author F. L. Morton). This article exposes two prominent critiques of Knopff's constitutional writings as straw man arguments and provides a republican account of his constitutional theory. The first straw man argument is that Knopff supports a majoritarian or populist conception of direct democracy. This claim is belied by Knopff's embrace of representative democracy and institutions structured to encourage reflexive deliberation. The second straw man argument is that Knopff is a moral rights skeptic. Knopff's rights skepticism is a legal skepticism about the determinacy of many rights that is merely a function of his inclusive legal positivism. The article concludes by reflecting on the republican lessons that Knopff's constitutional scholarship continues to offer, including how holding legislatures responsible for settling reasonable disagreements about legally indeterminate Charter rights might help counteract the twin threats of populism and juristocracy.
The Sculpted and Architectural Stonework from Stanwick Roman Villa, Northamptonshire
Authors: Coombe Penny , Hayward Kevin , Henig Martin 
Published: June 2021

ABSTRACTExcavated between 1984 and 1992, the site of a large Roman villa complex at Stanwick, Northamptonshire, produced a significant quantity of sculpted and architectural worked stone. This paper assesses the various aspects of that material, including the petrological sources, and offers a new interpretation. Many items were discovered as post-packing or were otherwise reused within the fabric of the enlarged fourth-century villa, but originally derived from what were probably two earlier monumental structures dated on stylistic grounds to the early third century. The sculpture was initially examined in 1994–95 by Martin Henig and the late Thomas Blagg, whose work, especially on the large number of architectural pieces, has been subsumed into this paper and to whom we owe a debt of gratitude. Supplementary material is available online (https://doi.org/10.1017/S0068113X21000052) and comprises additional figures and tables.
Permutable quasiregular maps
Authors: TSANTARIS ATHANASIOS 
Published: June 2021

AbstractLet f and g be two quasiregular maps in $\mathbb{R}^d$ that are of transcendental type and also satisfy
$f\circ g =g \circ f$
. We show that if the fast escaping sets of those functions are contained in their respective Julia sets then those two functions must have the same Julia set. We also obtain the same conclusion about commuting quasimeromorphic functions with infinite backward orbit of infinity. Furthermore we show that permutable quasiregular functions of the form f and
$g = \phi \circ f$
, where

$\phi$

is a quasiconformal map, have the same Julia sets and that polynomial type quasiregular maps cannot commute with transcendental type ones unless their degree is less than or equal to their dilatation.
Quality Indicators for Older Persons’ Transitions in Care: A Systematic Review and Delphi Process
Authors: Tate Kaitlyn , Lee Sarah , Rowe Brian H , Cummings Garnet E , Holroyd-Leduc Jayna , Reid R Colin , El-Bialy Rowan , Bakal Jeffrey , Estabrooks Carole A , Anderson Carol , Cummings Greta G 
Published: June 2021

AbstractWe identified quality indicators (QIs) for care during transitions of older persons (≥ 65 years of age). Through systematic literature review, we catalogued QIs related to older persons’ transitions in care among continuing care settings and between continuing care and acute care settings and back. Through two Delphi survey rounds, experts ranked relevance, feasibility, and scientific soundness of QIs. A steering committee reviewed QIs for their feasible capture in Canadian administrative databases. Our search yielded 326 QIs from 53 sources. A final set of 38 feasible indicators to measure in current practice was included. The highest proportions of indicators were for the emergency department (47%) and the Institute of Medicine (IOM) quality domain of effectiveness (39.5%). Most feasible indicators were outcome indicators. Our work highlights a lack of standardized transition QI development in practice, and the limitations of current free-text documentation systems in capturing relevant and consistent data.
Left ventricular thrombus in multisystem inflammatory syndrome in children associated with COVID-19
Authors: Schroder Jakob , Lund Morten Asp Vonsild , Vejlstrup Niels , Juul Klaus , Nygaard Ulrikka 
Published: June 2021

AbstractA 17-year-old adolescent with severe multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease-2019 developed reduced left ventricular function and left ventricular thrombus. With treatment, his condition improved and the thrombus was dissolved. This case illustrates the risk of severe intra-cardiac thrombotic complications in patients with MIS-C.
Global Coordination in Plant Physiological and Rooting Strategies in Response to Water Stress
Authors: Liu Yaling , Konings Alexandra G. , Kennedy Daniel , Gentine Pierre 
Published: June 2021

AbstractPlants employ a range of strategies to modulate the impact of water stress, including changes to rooting depth and hydraulic conductance (e.g., xylem conductance). However, it is still poorly understood how these strategies vary in relation to climate and land cover types and how they could coordinate globally. Based on daily microwave vegetation optical depth (VOD) from AMSR‐E and AMSR2 over 2002–2011, we estimate two proxies for stress regulation: (a) an effective plant rooting depth and (b) the effective plant hydraulic conductance to delineate two strategies: deep rooting and strong physiological regulation. We find that plants with deeper (e.g., evergreen/deciduous broadleaf forest) are mostly distributed in warm or wet regions, and maintain a relatively steady nighttime VOD because of access to deeper water. Taller plants exhibit greater drop in daytime VOD due to their greater physiological vulnerability. While physiological regulation appears to be the dominant water stress regulation strategy at Northern high latitudes where open shrubland and (woody) savannas are distributed, this physiological regulation is coupled with deep rooting in forest and (woody) savanna areas in the tropics, Eastern US, and Southeastern China. Meanwhile, grasslands in the Western US, Central Asia, Northeastern China, and Mongolia Plateau may be the regions most susceptible to water stress impact because neither water stress mitigation strategy is present. This new framework paves the road for a better understanding of plant water stress strategies at the global scale, and for enhancing large‐scale drought prediction and drought impact assessment in Earth system models by improving plant water stress response.