bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyberbullying behavior: A study of emotional maturity Yogyakarta students
Authors: Hutagaol Chornelius 
Published: July 2021

Purpose - The research objective was to determine the relationship between emotional maturity and cyberbullying behavior among students.Method - This research is a case study using a quantitative method based on a post-positivism approach. The sampling technique in this study using purposive sampling technique. The number of subjects in this study amounted to 60 students. The data analysis technique used product moment correlation.Result - The results of the research analysis using the "product moment" correlation technique showed a correlation number of -0.720 (p 0.01). The correlation coefficient value shows -0.720 which means that it has a very strong relationship level. Thus, the higher the emotional maturity, the lower the cyberbullying behavior, and the lower the emotional maturity, the higher the cyberbullying behavior.Implications – To define university-Students are included in the early adulthood stage which should have good emotional maturity. High emotional maturity allows individuals to have the ability to understand reality and facts and the quality of responding to situations by separating pressure and attraction for pleasant and unpleasant feelings.Originality - This research is cyberbullying behavior study using a quantitative method based on a post-positivism approach.***Tujuan - Penelitian ini bertujuan untuk mengetahui hubungan antara kematangan emosi dengan perilaku cyberbullying pada mahasiswa.Metode - Penelitian ini merupakan studi kasus dengan menggunakan metode kuantitatif dengan pendekatan post-positivisme. Teknik pengambilan sampel dalam penelitian ini menggunakan teknik purposive sampling. Jumlah subjek dalam penelitian ini berjumlah 60 siswa. Teknik analisis data menggunakan korelasi product moment.Hasil - Hasil analisis dengan teknik korelasi product moment menunjukkan angka korelasi sebesar -0,720 (p0,01). Nilai koefisien korelasi menunjukkan -0,720 yang berarti memiliki tingkat hubungan yang sangat kuat. Dengan demikian, semakin tinggi kematangan emosi maka semakin rendah perilaku cyberbullying, dan semakin rendah kematangan emosi maka semakin tinggi perilaku cyberbullying.Implikasi - Untuk mendefinisikan mahasiswa termasuk dalam tahap dewasa awal yang harus memiliki kematangan emosi yang baik. Kematangan emosi yang tinggi memungkinkan individu memiliki kemampuan untuk memahami realitas dan fakta serta kualitas dalam merespon situasi dengan memisahkan tekanan dan ketertarikan terhadap perasaan menyenangkan dan tidak menyenangkan.Originalitas - Penelitian ini merupakan penelitian perilaku cyberbullying dengan menggunakan metode kuantitatif dengan pendekatan post-positivisme.
The description of inmates’ coping skills of class IIA women's prison in Semarang
Authors: Rimayati Elfi , Sayekti Sri , Redjeki Sri 
Published: July 2021

Purpose - The purpose of this study was to determine the coping skills of inmates in living their lives. Method - The method used in this research was descriptive quantitative, with a population of 378 people consisting of 48 adult prisoners, 330 adult inmates. Sampling was based on the Krecjie table with a sample total of 182 people.Result - The results of calculating the coping skills of the inmates from the five indicators that have been determined obatained an average number of 76.7%. Based on the results of the average coping skills, it can be concluded that the coping skills of Class II A Women's Prison in Semarang are included in the good category.Implications – The results of this study are expected to be input in improving correctional services at the Class IIA Women's Prison in Semarang.Originality - This research is the study analysis coping skills of inmates in living their lives in the Class IIA Women's Prison in Semarang.***Tujuan - Tujuan dari penelitian ini adalah untuk mengetahui keterampilan koping narapidana dalam menjalani kehidupan mereka.Metode - Metode yang digunakan dalam penelitian ini adalah deskriptif kuantitatif, dengan populasi 378 orang yang terdiri dari 48 tahanan dewasa, 330 narapidana dewasa. Pengambilan sampel didasarkan pada tabel Krecjie dengan total sampel 182 orang.Hasil - Hasil penghitungan keterampilan koping narapidana dari lima indikator yang telah ditentukan ditampati jumlah rata-rata 76,7%. Berdasarkan hasil rata-rata keterampilan koping, dapat disimpulkan bahwa keterampilan koping dari kelas II penjara perempuan di Semarang termasuk dalam kategori baik.Implikasi - Hasil penelitian ini diharapkan menjadi input dalam meningkatkan layanan pemasyarakatan di penjara perempuan IIA kelas di SemarangOriginalitas - Penelitian ini adalah penelitian studi keterampilan mengatasi narapidana dalam menjalani kehidupan mereka di penjara wanita IIA di Semarang.
Leakage detection in water distribution networks by the use of analytical and experimental models
Authors: Nasirian Ali , Maghrebi Mahmoud F. , Mohtashami Ali 
Published: July 2021

Abstract
Recently, calibration based methods are considered to determine the quantities and locations of all leakages in a water distribution network (WDN), simultaneously. In this paper, the accuracy of detecting leakages using Ant Colony Optimization (ACO) in two networks including a hypothetical and a laboratory network is investigated. A novel method is introduced to analyze the effects of measurement errors on demand calibration in an under-determined problem. The results confirm the ability of the optimization-based method in detecting the exact locations and values of the leakages in a WDN. Also, it is emphasized that merely suitable fitnesses cannot provide sufficient confidence in result accuracy. To overcome this difficulty, the correctness of leakage detection can be verified in a sampling design problem. Moreover, to check the reliability of leakage detection an alternative method based on various results is introduced in this research.
Clinical Effects of Dual Antiplatelet Therapy or Aspirin Monotherapy after Acute Minor Ischemic Stroke or Transient Ischemic Attack, a Meta-Analysis
Authors: Condello Francesco , Liccardo Gaetano , Ferrante Giuseppe 
Published: July 2021

Background:
Evidence about the use of dual antiplatelet therapy (DAPT) with aspirin and P2Y12 inhibitors
in patients with acute minor ischemic stroke or transient ischemic attack (TIA) is emerging. The aim of
our study was to provide an updated and comprehensive analysis about the risks and benefits of DAPT versus
aspirin monotherapy in this setting.

Methods:
The PubMed, Embase, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov databases,
main international conference proceedings were searched for randomized controlled trials comparing DAPT
versus aspirin monotherapy in patients with acute ischemic stroke or TIA not eligible for thrombolysis or
thrombectomy presenting in the first 24 hours after the acute event. Data were pooled by meta-analysis using a
random-effects model. The primary efficacy endpoint was ischemic stroke recurrence, and the primary safety
outcome was major bleeding. Secondary endpoints were intracranial hemorrhage, hemorrhagic stroke, and allcause
death.

Results:
A total of 4 studies enrolling 21,459 patients were included. DAPT with clopidogrel was used in 3
studies, DAPT with ticagrelor in one study. DAPT duration was 21 days in one study, 1 month in one study,
and 3 months in the remaining studies. DAPT was associated with a significant reduction in the risk of ischemic
stroke recurrence (relative risk (RR), 0.74; 95% confidence interval (CI), 0.67-0.82, P<0.001, number needed to
treat 50 (95% CI 40-72), while it was associated with a significantly higher risk of major bleeding (RR, 2.59;
95% CI 1.49-4.53, P=0.001, number needed to harm 330 (95% CI 149-1111), of intracranial hemorrhage (RR
3.06, 95% CI 1.41-6.66, P=0.005), with a trend towards higher risk of hemorrhagic stroke (RR 1.83, 95% CI
0.83-4.05, P=0.14), and a slight tendency towards higher risk of all-cause death (RR 1.30, 95% CI 0.89-1.89,
P=0.16).

Conclusions:
Among patients with acute minor ischemic stroke or TIA, DAPT, as compared with aspirin monotherapy,
might offer better effectiveness in terms of ischemic stroke recurrence at the expense of a higher risk of
major bleeding. The trade-off between ischemic benefits and bleeding risks should be assessed in tailoring the
therapeutic strategies.
Isolated Tongue Angioedema after Alteplase Infusion in Acute Ischemic
Stroke
Authors: Pisani Ermanno , Gaudiano Carmen , Petrone Alfredo , Stancati Furio , Siniscalchi Antonio 
Published: July 2021

Background:
Angioedema, like anaphylaxis, has been reported as a rare adverse event
of alteplase infusion in acute ischemic stroke.

Objective:
We report the case of a patient with acute ischemic stroke who, after treatment of alteplase,
developed angioedema.

Methods:
We report the case of an 81-year-old woman who presented to our observation with
acute ischemic stroke. The patient was on therapy with 100 mg acetylsalicylic acid and a triple
combination antihypertensive drug (perindopril 10 mg + 2.5 mg indapamide + 5 mg amlodipine).
The patient was treated with alteplase infusion.

Results:
Five minutes after the end of the alteplase infusion (0.9 mg/kg for 1 hour), the patient developed
isolated angioedema of the lips and tongue.

Conclusion:
Although the incidence of alteplase-induced angioedema in these patients is rare, this
case report suggests the need for a routine inspection of the tongue in an acute ischemic patient in
treatment with alteplase infusion, especially in female patients in treatment with ACE inhibitors.
Acute Kidney Injury Related to Intravenous Colistin Use in Lebanese Hospitalized Patients: Incidence and Associated Factors
Authors: Khalifeh Malak , El-Lakany Abdalla , Soubra Lama 
Published: July 2021

Introduction:
Colistin use has increased because of the emergence of infections caused
by resistant gram-negative bacteria. Acute kidney injury (AKI) remains a treatment-limiting factor
for widespread colistin clinical use. This study aimed at determining the incidence and the factors
associated with the development of colistin-induced AKI.

Method:
A retrospective observational study was conducted by reviewing files of adult patients
with normal kidney function between January 2015 to March 2019 at a university hospital located
in Beirut city. AKI was defined based on KDIGO criteria. Independent variables associated with
colistin-induced AKI were also tested.

Results:
In this study, a total of 113 patients were included. AKI occurred in 53 patients (46.9%).
The Charlson Comorbidity Index (CCI) was found to be significantly greater in the AKI group
(2.26, P-value = 0.026). In the multivariate analysis, low serum albumen was found as an independent
significant predictor for AKI (OR=.065, 95%CI: .013-.337, P-value=0.001). Moreover, the
risk for AKI increased by 2 folds (OR=2.019, 95%CI: 1.094-3.728, P-value: 0.025), when two or
more nephrotoxic agents were administered simultaneously with colistin. The patient’s age was also
found as a significant predictor for AKI (OR=1.034, 95%CI:1-1.07), with a cut-off value of
58.5-year-old.

Conclusion:
This study demonstrated that the concomitant use of two or more nephrotoxic drugs,
patient’s age of 58.5 or above, and the presence of hypoalbuminemia were independent factors for
the development of colistin-induced AKI. These factors should be therefore taken into consideration
when prescribing colistin in clinical practice to decrease the risk of AKI.
Synthesis and Anticancer Evaluation of Sulfur Containing 9-anilinoacridines
Authors: Kwon Chul-Hoon , Chen Zhe-Sheng , Gupta Pranav , Kumar Radhika V. 
Published: July 2021

Background:
DNA topoisomerases are a class of enzymes that play a critical role in fundamental
biological processes of replication, transcription, recombination, repair and chromatin remodeling.
Amsacrine (m-AMSA), the best-known compound of 9-anilinoacridines series, was one
of the first DNA-intercalating agents to be considered a Topoisomerase II inhibitor.

Objective:
A series of sulfur-containing 9-anilinoacridines related to amsacrine were synthesized
and evaluated for their anticancer activity.

Methods:
using the Human topoisomerase II Assay kit, and flow cytometry was used to evaluate
the effects on the cell cycle of K562 cells. Molecular docking was performed using the
Schrödinger Maestro program.

Results:
Compound 36 was found to be the most cytotoxic of the sulfide series against SW620,
K562, and MCF-7. The limited SAR suggested the importance of the methansulfonamidoacetamide
side chain functionality, the lipophilicity, and the relative metabolic stability of 36 in contributing
to the cytotoxicity. Topoisomerase II α inhibitory activity appeared to be involved in the
cytotoxicity of 36 through the inhibition of decatenation of kinetoplast DNA (kDNA) in a concentration-
dependent manner. Cell cycle analysis further showed Topo II inhibition through the accumulation
of K562 cells in the G2/M phase of the cell cycle. The docking of 36 into the Topo II α-DNA
complex suggested that it may be an allosteric inhibitor of Topo II α.

Conclusion:
Compound 36 exhibits anticancer activity by inhibiting topoisomerase II, and it could
further be evaluated in in vivo models.
Regulation of Microtubule: Current Concepts and Relevance to Neurodegenerative Diseases
Authors: Ghosh Anirban , Singh Shamsher 
Published: July 2021

:Neurodevelopmental Disorders (NDDs) are abnormalities linked to neuronal structure and irregularities associated with the proliferation of cells, transportation, and differentiation. NDD also involves synaptic circuitry and neural network alterations known as synaptopathy. Microtubules (MTs) and MTs-associated proteins help to maintain neuronal health as well as their development. The microtubular dynamic structure plays a crucial role in the division of cells and forms mitotic spindles, thus take part in initiating stages of differentiation and polarization for various types of cells. The MTs also take part in cellular death, but MT-based cellular degenerations are not yet well excavated. In the last few years, studies have provided the protagonist activity of MTs in neuronal degeneration. In this review, we largely engrossed our discussion on the change of MT cytoskeleton structure, describing their organization, dynamics, transportation, and their failure causing NDDs. At the end of this review, we are targeting the therapeutic neuroprotective strategies on clinical priority and also try to discuss the clues for the development of new MT-based therapy as a new pharmacological intervention. This will be a new potential site to block not only neurodegeneration but also promotes the regeneration of neurons.
Size Matters: Body Size is Correlated with Longevity in Speckled Cockroaches (Nauphoeta cineria)
Authors: Badwan Sami , Harper James 
Published: July 2021

Background:
A relationship between body size and longevity has long been appreciated
within eukaryotes, especially vertebrates.

Introduction:
In general, the large size is associated with increased longevity among species of
mammals and birds but is associated with decreased longevity within individual species such as
dogs and mice. In this study, we examined the relationship between measures of individual body
size and longevity in a captive population of speckled cockroaches (Nauphoeta cineria).

Methods:
Newly molted adults of both sexes were removed from a mass colony housed in multiple
terraria and housed individually with food and water provided ad libitum for the duration of their
lifespan. Thrice weekly, the status (i.e., live/dead) of individual cockroaches was noted for the duration
of the study. Individuals found dead were weighed and measured to obtain body mass and
morphometric measures, and the age at the time of death was recorded. The relationship between
body size and lifespan was assessed.

Result:
Contrary to what is commonly seen within vertebrates, large cockroaches were longerlived
than their smaller counterparts. Specifically, body mass, body length, and pronotum width
were all significantly correlated with the age at death in a mixed population of males and females
(n = 94). In addition, we found that the longevity of a historically larger population in terms of both
body mass and body length was significantly longer-lived than the population used in this study.

Conclusion:
These data indicate there is a significant interaction between body size and aging in
this species and that increased size results in a survival advantage. There is evidence in the literature
indicating that a positive relationship between size and longevity may be common in insects.
Pleuroscopy Early Experience in the Exudative Pleural Effusion of Unknown Etiology
Authors: Fakharian Atefeh , Jabbardarjani Hamidreza , Masjedi Mohamad Reza , Shamaei Masoud 
Published: July 2021

Background:
Pleuroscopy (medical thoracoscopy) is a minimally invasive procedure to
inspect and perform a biopsy of the pleural space as well as to perform therapeutic interventions;
pleural fluid drainage and pleurodesis.

Material and Methods:
In a retrospective study in Kasra Hospital, Tehran,Iran, the patients with
exudative pleural effusion of unknown etiology who underwent pleuroscopy, were evaluated. These
patients had negative smears and cultures for infective agents. Also, the cytological review was
negative for malignancy.

Results:
62 patients had undergone pleuroscopy, of which 29 (46.7) were men. After the final evaluation,
47 patients (75.8%) had a definite pathologic diagnosis, of which 39 patients (82.9%) had
cancer. Through these 39 cases, 18 cases (46.1%) had a history of the previously confirmed cancer,
in which pleural pathology was consistent with the initial diagnosis. In 21 cases (53.9%), metastatic
cancers were detected without a previous history. From a total of 47 cases with definite pathologic
diagnosis, 8 cases (17%) had histopathologic evidence of granulomatous lesions consistent with
tuberculosis, and 15 patients (24%) showed non-specific inflammatory lesions. There was no morbidity
and mortality among these patients.

Discussion:
Considering that pleuroscopy is a safe procedure with high diagnostic accuracy, malignancy
is the most common finding in the exudative pleural effusion of unknown etiology, which increases
the importance of this procedure in these cases to prevent wasting time and smear-negative
anti-TB treatment.
Augmented Reality in Pediatric Septic Shock Simulation: Randomized Controlled Feasibility Trial
Authors: Toto Regina L , Vorel Ethan S , Tay Khoon-Yen E , Good Grace L , Berdinka Jesse M , Peled Adam , Leary Marion , Chang Todd P , Weiss Anna K , Balamuth Frances B 
Published: July 2021

Background
Septic shock is a low-frequency but high-stakes condition in children requiring prompt resuscitation, which makes it an important target for simulation-based education.

Objective
In this study, we aimed to design and implement an augmented reality app (PediSepsisAR) for septic shock simulation, test the feasibility of measuring the timing and volume of fluid administration during septic shock simulation with and without PediSepsisAR, and describe PediSepsisAR as an educational tool. We hypothesized that we could feasibly measure our desired data during the simulation in 90% of the participants in each group. With regard to using PediSepsisAR as an educational tool, we hypothesized that the PediSepsisAR group would report that it enhanced their awareness of simulated patient blood flow and would more rapidly verbalize recognition of abnormal patient status and desired management steps.

Methods
We performed a randomized controlled feasibility trial with a convenience sample of pediatric care providers at a large tertiary care pediatric center. Participants completed a prestudy questionnaire and were randomized to either the PediSepsisAR or control (traditional simulation) arms. We measured the participants’ time to administer 20, 40, and 60 cc/kg of intravenous fluids during a septic shock simulation using each modality. In addition, facilitators timed how long participants took to verbalize they had recognized tachycardia, hypotension, or septic shock and desired to initiate the sepsis pathway and administer antibiotics. Participants in the PediSepsisAR arm completed a poststudy questionnaire. We analyzed data using descriptive statistics and a Wilcoxon rank-sum test to compare the median time with event variables between groups.

Results
We enrolled 50 participants (n=25 in each arm). The timing and volume of fluid administration were captured in all the participants in each group. There was no statistically significant difference regarding time to administration of intravenous fluids between the two groups. Similarly, there was no statistically significant difference between the groups regarding time to verbalized recognition of patient status or desired management steps. Most participants in the PediSepsisAR group reported that PediSepsisAR enhanced their awareness of the patient’s perfusion.

Conclusions
We developed an augmented reality app for use in pediatric septic shock simulations and demonstrated the feasibility of measuring the volume and timing of fluid administration during simulation using this modality. In addition, our findings suggest that PediSepsisAR may enhance participants’ awareness of abnormal perfusion.
Using Electronically Delivered Therapy and Brain Imaging to Understand Obsessive-Compulsive Disorder Pathophysiology: Protocol for a Pilot Study
Authors: Stephenson Callum , Malakouti Niloufar , Nashed Joseph Y , Salomons Tim , Cook Douglas J , Milev Roumen , Alavi Nazanin 
Published: July 2021

Background
Obsessive-compulsive disorder (OCD) is a debilitating and prevalent anxiety disorder. Although the basal ganglia and frontal cortex are the brain regions that are most commonly hypothesized to be involved in OCD, the exact pathophysiology is unknown. By observing the effects of proven treatments on brain activation levels, the cause of OCD can be better understood. Currently, the gold standard treatment for OCD is cognitive behavioral therapy (CBT) with exposure and response prevention. However, this is often temporally and geographically inaccessible, time consuming, and costly. Fortunately, CBT can be effectively delivered using the internet (electronically delivered CBT [e-CBT]) because of its structured nature, thus addressing these barriers.

Objective
The aims of this study are to implement an e-CBT program for OCD and to observe its effects on brain activation levels using functional magnetic resonance imaging (MRI). It is hypothesized that brain activation levels in the basal ganglia and frontal cortex will decrease after treatment.

Methods
Individuals with OCD will be offered a 16-week e-CBT program with exposure and response prevention mirroring in-person CBT content and administered through a secure web-based platform. The efficacy of the treatment will be evaluated using clinically validated symptomology questionnaires at baseline, at week 8, and after treatment (week 16). Using functional MRI at baseline and after treatment, brain activation levels will be assessed in the resting state and while exposed to anxiety-inducing images (eg, dirty dishes if cleanliness is an obsession). The effects of treatment on brain activation levels and the correlation between symptom changes and activation levels will be analyzed.

Results
The study received initial ethics approval in December 2020, and participant recruitment began in January 2021. Participant recruitment has been conducted through social media advertisements, physical advertisements, and physician referrals. To date, 5 participants have been recruited. Data collection is expected to conclude by January 2022, and data analysis is expected to be completed by February 2022.

Conclusions
The findings from this study can further our understanding of the causation of OCD and help develop more effective treatments for this disorder.

Trial Registration
ClinicalTrials.gov NCT04630197; https://clinicaltrials.gov/ct2/show/NCT04630197.

International Registered Report Identifier (IRRID)
PRR1-10.2196/30726