bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correspondence Between Clinician Ratings of Vulvovaginal Health and Patient-Reported Sexual Function After Cancer
Authors: Flynn Kathryn E. , Lin Li , Carter Jeanne , Baser Raymond E. , Goldfarb Shari , Saban Sally , Weinfurt Kevin P. 
Published: August 2021

ABSTRACTBackgroundTools for diagnosing sexual dysfunction and for tracking outcomes of interest include clinician interviews, physical exam, and patient self-report. Limited work has described relationships among these three sources of information regarding female sexual dysfunction and vulvovaginal health.AimWe describe correlations among data collected from clinician interviews, clinical gynecological examination, and patient self-report.MethodsData are from a single-site, single-arm, prospective trial in 100 postmenopausal patients with a history of breast or endometrial cancer who sought treatment for vulvovaginal symptoms. The trial collected a standardized clinical gynecologic exam, clinician-reported outcome (ClinRO) measures of vulvovaginal dryness and pain, and patient-reported outcome (PRO) measures of sexual function, including PROMIS Sexual Function and Satisfaction (SexFS) lubrication, vaginal discomfort, labial discomfort, and clitoral discomfort and Female Sexual Function Index (FSFI) lubrication and pain. We examined polyserial correlations between measures with bootstrapped 95% confidence intervals from the baseline and 12–14-week timepoints.RESULTSAll of the relationships between the ClinRO variables and the PRO variables were in the expected direction (ie, positive), but the strength of the relationships varied substantially. At 12–14 weeks, there were medium-to-large correlations between ClinRO vaginal dryness and SexFS Lubrication (0.64), ClinRO vulvar dryness and SexFS Lubrication (0.46), ClinRO vulvar discomfort and SexFS Labial Discomfort (0.70), and ClinRO vulvar discomfort and SexFS Clitoral Discomfort (0.43). With one exception, the correlations between the exam variables and the corresponding PRO scores were small (range 0.01–0.27).Strengths & LimitationsOur study included a comprehensive, standardized gynecologic exam designed specifically to evaluate sexual dysfunction as well as established PRO measures with significant evidence for validity. A limitation of our findings is that the sample size was relatively small, and our sample was restricted to women who received cancer treatments known to have dramatic effects on vulvovaginal tissue quality.CONCLUSIONPatient- and clinician-reported vulvovaginal dryness and discomfort were moderately correlated with each other but not with clinical gynecologic exam findings. Understanding the relationships among these different types of data highlights the distinct contributions of each to understand vulvovaginal tissue quality and patient sexual function after cancer.
Descent of Darwin: race, sex, and human nature
Authors: Milam Erika Lorraine , Seth Suman 
Published: August 2021

AbstractIn 1871, Charles Darwin published Descent of Man and Selection in Relation to Sex, a text that extended, elaborated and completed his On the Origin of Species (1859). When he had published Origin, Darwin sought, albeit unsuccessfully, to skirt controversy; in Descent he waded into the fray on near-innumerable issues. Readers could find explicit the claim that humans had descended from apes, in addition to explorations of the similarities and apparent gulfs between ‘man’ and other animals. They also found Darwin's opinions on issues ranging from the origin and hierarchy of races to the question of women's education, from the source of altruistic bravery to the biological importance of aesthetic judgement, from his views on what his cousin would term ‘eugenics’ to the history of monogamy. In the last 150 years these ideas have been variously contested, rejected and recovered, so that the shadow of Descent extended into debates over the development of languages, the evolution of human sexualities, the ongoing possibilities of eugenics and the question of women's equality. In this volume, appearing during the sesquicentennial of the text's first appearance, one finds papers dedicated to all of these themes and more, laying out the roots and fruits of Darwin's Descent.
Carnap and Beth on the Limits of Tolerance
Authors: Marschall Benjamin 
Published: August 2021

AbstractRudolf Carnap’s principle of tolerance states that there is no need to justify the adoption of a logic by philosophical means. Carnap uses the freedom provided by this principle in his philosophy of mathematics: he wants to capture the idea that mathematical truth is a matter of linguistic rules by relying on a strong metalanguage with infinitary inference rules. In this paper, I give a new interpretation of an argument by E. W. Beth, which shows that the principle of tolerance does not suffice to remove all obstacles to the employment of infinitary rules.
Cross cultural and global uses of a digital mental health app: results of focus groups with clinicians, patients and family members in India and the United States
Authors: Rodriguez-Villa Elena , Rozatkar Abhijit R. , Kumar Mohit , Patel Vikram , Bondre Ameya , Naik Shalini S. , Dutt Siddharth , Mehta Urvakhsh M. , Nagendra Srilakshmi , Tugnawat Deepak , Shrivastava Ritu , Raghuram Harikeerthan , Khan Azaz , Naslund John A. , Gupta Snehil , Bhan Anant , Thirthall Jagadisha , Chand Prabhat K. , Lakhtakia Tanvi , Keshavan Matcheri , Torous John 
Published: August 2021

AbstractBackgroundDespite significant advancements in healthcare technology, digital health solutions – especially those for serious mental illnesses – continue to fall short of their potential across both clinical practice and efficacy. The utility and impact of medicine, including digital medicine, hinges on relationships, trust, and engagement, particularly in the field of mental health. This paper details results from Phase 1 of a two-part study that seeks to engage people with schizophrenia, their family members, and clinicians in co-designing a digital mental health platform for use across different cultures and contexts in the United States and India.MethodsEach site interviewed a mix of clinicians, patients, and their family members in focus groups (n= 20) of two to six participants. Open-ended questions and discussions inquired about their own smartphone use and, after a demonstration of the mindLAMP platform, specific feedback on the app's utility, design, and functionality.ResultsOur results based on thematic analysis indicate three common themes: increased use and interest in technology during coronavirus disease 2019 (COVID-19), concerns over how data are used and shared, and a desire for concurrent human interaction to support app engagement.ConclusionPeople with schizophrenia, their family members, and clinicians are open to integrating technology into treatment to better understand their condition and help inform treatment. However, app engagement is dependent on technology that is complementary – not substitutive – of therapeutic care from a clinician.
Healthcare microenvironments define multidrug-resistant organism persistence
Authors: Kelly Brendan J. , Bekele Selamawit , Loughrey Sean , Huang Elizabeth , Tolomeo Pam , David Michael Z. , Lautenbach Ebbing , Han Jennifer H. , Ziegler Matthew J. ,   for the CDC Prevention Epicenters Program
Published: August 2021

AbstractBackground:Multidrug-resistant organisms (MDROs) colonizing the healthcare environment have been shown to contribute to risk for healthcare-associated infections (HAIs), with adverse effects on patient morbidity and mortality. We sought to determine how bacterial contamination and persistent MDRO colonization of the healthcare environment are related to the position of patients and wastewater sites.Methods:We performed a prospective cohort study, enrolling 51 hospital rooms at the time of admitting a patient with an eligible MDRO in the prior 30 days. We performed systematic sampling and MDRO culture of rooms, as well as 16S rRNA sequencing to define the environmental microbiome in a subset of samples.Results:The probability of detecting resistant gram-negative organisms, including Enterobacterales, Acinetobacter spp, and Pseudomonas spp, increased with distance from the patient. In contrast, Clostridioides difficile and methicillin-resistant Staphylococcus aureus were more likely to be detected close to the patient. Resistant Pseudomonas spp and S. aureus were enriched in these hot spots despite broad deposition of 16S rRNA gene sequences assigned to the same genera, suggesting modifiable factors that permit the persistence of these MDROs.Conclusions:MDRO hot spots can be defined by distance from the patient and from wastewater reservoirs. Evaluating how MDROs are enriched relative to bacterial DNA deposition helps to identify healthcare micro-environments and suggests how targeted environmental cleaning or design approaches could prevent MDRO persistence and reduce infection risk.
A minimal space interferometer configuration for imaging at low radio frequencies
Authors: Jaini Akhil , Deshpande Avinash A. , Bitragunta Sainath 
Published: August 2021

Abstract
The radio sky at lower frequencies, particularly below 20 MHz, is expected to be a combination of increasingly bright non-thermal emission and significant absorption from intervening thermal plasma. The sky maps at these frequencies cannot therefore be obtained by simple extrapolation of those at higher frequencies. However, due to severe constraints in ground-based observations, this spectral window still remains greatly unexplored. In this paper, we propose and study, through simulations, a novel minimal configuration for a space interferometer system which would enable imaging of the radio sky at frequencies well below 20 MHz with angular resolutions comparable to those achieved at higher radio frequencies in ground-based observations by using the aperture synthesis technique. The minimal configuration consists of three apertures aboard Low Earth Orbit (LEO) satellites orbiting the Earth in mutually orthogonal orbits. Orbital periods for the satellites are deliberately chosen to differ from each other so as to obtain maximum (u,v) coverage in short time spans with baselines greater than 15 000 km, thus, giving us angular resolutions finer than 10 arcsec even at these low frequencies. The sensitivity of the (u,v) coverage is assessed by varying the orbit and the initial phase of the satellites. We discuss the results obtained from these simulations and highlight the advantages of such a system.
Late Ediacaran organic microfossils from Finland
Authors: Willman Sebastian , Slater Ben J. 
Published: August 2021

AbstractHere we present a detailed accounting of organic microfossils from late Ediacaran sediments of Finland, from the island of Hailuoto (northwest Finnish coast), and the Saarijärvi meteorite impact structure (~170 km northeast of Hailuoto, mainland Finland). Fossils were recovered from fine-grained thermally immature mudstones and siltstones and are preserved in exquisite detail. The majority of recovered forms are sourced from filamentous prokaryotic and protistan-grade organisms forming interwoven microbial mats. Flattened Nostoc-ball-like masses of bundled Siphonophycus filaments are abundant, alongside Rugosoopsis and Palaeolyngbya of probable cyanobacterial origin. Acritarchs include Chuaria, Leiosphaeridia, Symplassosphaeridium and Synsphaeridium. Significantly, rare spine-shaped sclerites of bilaterian origin were recovered, providing new evidence for a nascent bilaterian fauna in the terminal Ediacaran. These findings offer a direct body-fossil insight into Ediacaran mat-forming microbial communities, and demonstrate that alongside trace fossils, detection of a bilaterian fauna prior to the Cambrian might also be sought among the emerging record of small carbonaceous fossils (SCFs).
Fermented foods and probiotics: An approach to lactose intolerance
Authors: Ibrahim Salam A. , Gyawali Rabin , Awaisheh Saddam S. , Ayivi Raphael D. , Silva Roberta C. , Subedi Kiran , Aljaloud Sulaiman O. , Anusha Siddiqui Shahida , Krastanov Albert 
Published: August 2021

AbstractThe aim of this review was to present various topics related to lactose intolerance with special attention given to the role of fermented foods and probiotics in alleviating gastrointestinal symptoms. Lactose intolerance is a common digestive problem in which the human body is unable to digest lactose, known as milk sugar. Lactose intolerance can either be hereditary or a consequence of intestinal diseases. Recent work has demonstrated that fermented dairy products and probiotics can modify the metabolic activities of colonic microbiota and may alleviate the symptoms of lactose intolerance. We suggest that, lactose free dairy products could be recommended as alternatives for the alleviation of lactose intolerance and for the promotion of human health and wellness.
Intracellular Staphylococcus aureus inhibits autophagy of bovine mammary epithelial cells through activating p38α
Authors: Wang Run , Zhang Wen , Wang Lumei , Geng Na , Wang Xiaozhou , Zhang Meihua , Liu Jianzhu , Liu Yongxia , Han Bo 
Published: August 2021

AbstractStaphylococcus aureus is a common pathogen of bovine mastitis which can induce autophagy and inhibit autophagy flux, resulting in intracellular survival and persistent infection. The aim of the current study was to investigate the role of p38α in the autophagy induced by intracellular S. aureus in bovine mammary epithelial cells. An intracellular infection model of MAC-T cells was constructed, and activation of p38α was examined after S. aureus invasion. Through activating/inhibiting p38α by anisomycin/SB203580, the autophagosomes, LC3 and p62 level were analyzed by immunofluorescence and western blot. To further study the detailed mechanism of p38α, phosphorylation of ULK1ser757 was also detected. The results showed that intracellular S. aureus activated p38α, and the activation developed in a time-dependent manner. Inhibition of p38α promoted intracellular S. aureus-induced autophagy flow, up-regulated the ratio of LC3 II/I, reduced the level of p62 and inhibited the phosphorylation of ULK1ser757, whereas the above results were reversed after activation of p38α. The current study indicated that intracellular S. aureus can inhibit autophagy flow by activating p38α in bovine mammary epithelial cells.
The COVID-19 Crisis and the Allocation of Capital
Authors: Duchin Ran , Harford Jarrad 
Published: August 2021

AbstractWe summarize and synthesize the results of the articles in this symposium issue on research in financial economics related to the COVID-19 pandemic. We argue that the articles, taken together, present evidence that the pandemic resulted in a distributional shock to capital allocation. The underlying mechanisms include accelerating technological shifts, government stimulus programs, and heterogeneous responses of investors and firms. We augment these articles with evidence on the heterogeneous effects of the pandemic on profitability, payout, investment, employment, and productivity across sectors.
Mortality among inpatients with bipolar disorders and COVID-19: a propensity score matching analysis in a national French cohort study
Authors: Fond Guillaume , Pauly Vanessa , Leone Marc , Orleans Veronica , Garosi Alexandra , Lancon Christophe , Auquier Pascal , Baumstarck Karine , Llorca Pierre-Michel , Boyer Laurent 
Published: August 2021

AbstractBackgroundIt remains unknown whether coronavirus disease 2019 (COVID-19) patients with bipolar disorders (BDs) are at an increased risk of mortality. We aimed to establish whether health outcomes and care differed between patients infected with COVID-19 with BD and patients without a diagnosis of severe mental illness.MethodsWe conducted a population-based cohort study of all patients with identified COVID-19 and respiratory symptoms who were hospitalized in France between February and June 2020. The outcomes were in-hospital mortality and intensive care unit (ICU) admission. We used propensity score matching to control for confounding factors.ResultsIn total, 50 407 patients were included, of whom 480 were patients with BD. Patients with BD were 2 years older, more frequently women and had more comorbidities than controls without a diagnosis of severe mental illness. Patients with BD had an increased in-hospital mortality rate (26.6%v.21.9%;p= 0.034) and similar ICU admission rate (27.9%v.28.4%,p= 0.799), as confirmed by propensity analysis [odds ratio, 95% confidence interval (OR, 95% CI) for mortality: 1.30 (1.16–1.45),p< 0.0001]. Significant interactions between BD and age and between BD and social deprivation were found, highlighting that the most important inequalities in mortality were observed in the youngest [OR, 95% CI 2.28 (1.18–4.41),p= 0.0015] and most deprived patients with BD [OR, 95% CI 1.60 (1.33–1.92),p< 0.001].ConclusionsCOVID-19 patients with BD were at an increased risk of mortality, which was exacerbated in the youngest and most deprived patients with BD. Patients with BD should thus be targeted as a high-risk population for severe forms of COVID-19, requiring enhanced preventive and disease management strategies.
Emergency Treatment of Anaphylactic Reactions in Air Rescue Missions: An Eight-Year Analysis of a German Rescue Helicopter Base
Authors: Lakner Theresa , Cuevas Mandy , Polk Marie-Luise , Petrowski Katja , Frank Mark 
Published: August 2021

AbstractIntroduction:Anaphylactic reactions can lead to a life-threatening situation. In the event of anaphylaxis, rapid and targeted emergency treatment is indicated.Study Objective:The study sought to determine the emergency therapy administered for anaphylaxis in children and adults. Focus was placed on therapy with adrenaline. In addition, the study aimed to investigate demographic data, triggers, and hospitalization rates of the different severities of anaphylaxis.Methods:A retrospective analysis of anaphylactic reactions was conducted using data from prehospital emergency missions performed by the Air Rescue Dresden/Germany from 2008 through 2015 using the standardized application protocol EPRO-5.0 (MIND 3) anonymized. Data from 152 adults and 29 children were evaluated, focusing especially on the acute treatment as well as demographic information, triggers, and symptoms of anaphylactic reactions.Results:In total, 152 adults (73 female, 79 male) from 18 to 87 years (mean 50.5 years) and 29 children (9 female, 20 male) from 1 to 16 years (mean 7.5 years) with anaphylactic reactions were analyzed. The most common trigger for severe anaphylactic reactions (Grade II-IV; classification modified according to Ring and Messmer) was food in children (33%) and insect venom in adults (59%). The data show that 19% of adults with Grade II-IV anaphylactic reactions (classification modified according to Ring and Messmer) received adrenaline. Regarding children, the appliance of adrenaline was only administered in seven percent of the cases of Grade II-IV anaphylactic reactions. Adults with Grade II or higher anaphylactic reactions were hospitalized in 92%. Three percent refused hospitalization and five percent were not transferred to hospital. One-hundred percent of the children with Grade II-IV anaphylaxis were hospitalized.Conclusions:Analysis of data from the Air Rescue Dresden/Germany shows that despite existing recommendations, only 19% of adults with severe anaphylaxis received adrenaline. Among children, only in seven percent was a treatment with adrenaline performed.On the other hand, all patients survived the acute emergency treatment without apparent adverse outcomes. Thus, further studies are needed to determine the proper use of adrenaline in anaphylactic reactions.
Transitional dynamics of the saving rate and economic growth
Authors: Brueckner Markus , Kikuchi Tomoo , Vachadze George 
Published: August 2021

AbstractWe estimate the relationship between GDP per capita growth and the growth rate of the national saving rate using a panel of 130 countries over the period 1960–2017. We find that GDP per capita growth increases (decreases) the growth rate of the national saving rate in poor countries (rich countries), and a higher credit-to-GDP ratio decreases the national saving rate as well as the income elasticity of the national saving rate. We develop a model with a credit constraint to explain the growth-saving relationship by the saving behavior of entrepreneurs at both the intensive and extensive margins. We further present supporting evidence for our theoretical findings by utilizing cross-country time series data of the number of new businesses registered and the corporate saving rate.
Comparing the cognate effect in spoken and written second language word production
Authors: Muylle Merel , Van Assche Eva , Hartsuiker Robert J. 
Published: August 2021

AbstractCognates – words that share form and meaning between languages – are processed faster than control words. However, is this facilitation effect merely lexical in nature or does it cascade to phonological/orthographic (i.e., sub-lexical) processes? This study compared cognate effects in spoken and typewritten production, which share lexical, but not sub-lexical processes. Dutch–English bilinguals produced English names for pictures representing Dutch–English cognates and control words in either the spoken or typewritten modality. Onset latencies were shorter and accuracy was higher for cognates vs. control words and this effect was similar in both modalities. Compared to controls, total latencies in the written modality were similar for cognates with much cross-linguistic overlap, but longer for ones with less overlap. Additionally, error analysis showed that cognates were more affected by L1 interference than controls. These results suggest two different cognate effects: one at the lexical and one at the sub-lexical level.
Increasing our understanding of nonphysical suffering within palliative care: A scoping review
Authors: Rattner Maxxine 
Published: August 2021

AbstractObjectiveNonphysical suffering is emotional, psychological, existential, spiritual, and/or social in nature. While palliative care is a discipline dedicated to the prevention and relief of suffering — both physical and nonphysical — little is known about existing research specific to nonphysical suffering within the context of palliative care. This scoping review helps to fill this gap.MethodThree hundred and twenty-eight unique records were identified through a systematic search of three databases (MEDLINE, CINAHL, and PsycINFO). The following keywords were used: (suffering) AND (palliative OR “end of life” OR “end-of-life” OR hospice OR dying OR terminal* ill*). Thirty studies published between 1998 and 2019 met the inclusion criteria.ResultsLosses, worries, and fears comprise patients’ primary sources of nonphysical suffering. Patients face numerous barriers in expressing their nonphysical suffering to healthcare providers. The idea that patients can choose how they perceive their circumstances, thereby minimizing their nonphysical suffering, is pervasive in the research. The nature of nonphysical suffering experienced by family caregivers and palliative care clinicians is revealed in the review. The unique and sensitive interplay between nonphysical suffering and both palliative sedation and requests for hastened death is also evident. Overall, seven themes can be identified: (i) patients’ experiences of nonphysical suffering; (ii) patient coping mechanisms; (iii) efforts to measure nonphysical suffering; (iv) palliative sedation; (v) requests for hastened death; (vi) family suffering; and (vii) clinician suffering.Significance of resultsThis is the first scoping review to map palliative care's research specific to suffering that is social, emotional, spiritual, psychological, and/or existential in nature. Its findings expand our understanding of the nature of nonphysical suffering experienced by patients, families, and palliative care clinicians. The review's findings have significant implications for front-line practice and future research.