bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of CD44 and Ki-67 in oral squamous cell carcinoma
Authors: Kaur Harmanpreet , Raina Varsha , Singh Kunika , Varshney Anupam , Mohan Alok 
Published: December 2024

The present study was done to evaluate the immunohistochemical expression of CD44 and Ki-67 in cases of oral squamous cell carcinoma. A Hospital based observational study was conducted at the Department of pathology, in a tertiary teaching hospital in western Uttar Pradesh. The study included specimens of oral lesions undergone incisional biopsies and/or radical complete surgical resection diagnosed as squamous cell carcinoma. Specimens were grossed, processed, paraffin embedded, appropriate sections were taken and Haematoxylin and eosin stained, then examined under microscope. Immunohistochemical markers- CD44 and Ki-67 were applied. Most common sites were tongue (40.0%) and buccal mucosa (35.0%). The correlation of CD44 and Ki-67 score with histological grades in Oral Squamous Cell Carcinoma were significant in all three grades i.e., grade1, grade 2 and grade 3.The immunoexpression of CD44 may have prognostic significance in determining the tumour’s stage, grade, degree of invasiveness, and likelihood of metastasis. Ki-67 is a simple to use indicator of cell proliferation whose expression is positively correlated with the development of illness. As a result, it is a marker of carcinogenesis and malignant transformation in oral premalignant lesions. IHC methods may be costly and time-consuming, but their evaluation could be utilised to guide treatment choices for individuals with OSCC.
Prognostic assessment of baseline neutrophil-to-lymphocyte ratio in locally advanced and metastatic lung cancer: A retrospective analysis from a tertiary care center in Northeast India
Authors: Sarangi Satya Sadhan , Hazarika Munlima , Roy Partha Sarathi , Raj Nithin Daniel , Medhi Partha Pratim , Sarma Anupam 
Published: December 2024

The treatment for lung cancer has achieved notable advancements; however, there remains a critical need for the development of more refined strategies aimed at optimizing patient selection and enhancing the precision of prognostic evaluations for individuals afflicted with lung cancer. Leukocyte count, particularly neutrophils and lymphocytes, along with the Neutrophil to Lymphocyte ratio (NLR), stand as discerning markers of systemic inflammation, actively contributing in the regulation of cell-mediated antitumor responses. The primary objective of this study was to evaluate the prognostic implications associated with baseline NLR in patients diagnosed with locally advanced and metastatic lung cancer. Participants in this retrospective observational study were registered between January and December 2017 at the Dr. Bhubaneswar Borooah Cancer Institute. The demographic information, including clinical profiles and treatment-related characteristics, was gathered for these patients, who were diagnosed with locally advanced and metastatic lung cancer based on histological confirmation. The NLR was determined based on the quantification of neutrophils and lymphocytes. The survivorship between the groups was examined after two categories of NLR values—those with &#60; 3 and those with &#62; 3—were established. The Kaplan-Meier method was employed to analyze survival curves, and the log-rank test was performed to compare survival between different groups. In order to establish statistical significance, it was necessary for the p-value to be below 0.05. The cohort was predominantly elderly males, with a median age of 60 years. Non-small cell lung carcinoma (NSCLC) accounted for 94% of cases, predominantly adenocarcinoma (60%). Over 90% of individuals were diagnosed with stage IV disease. Most patients (53%) received chemotherapy, with a median survival of 11 months for those with NLR &#60; 3, compared to 8 months for NLR ≥ 3, though this difference lacked statistical significance (p=0.180). NSCLC patients with a smoking history exhibited significantly higher inflammation markers (NLR &#62; 3). Although high NLR was seen more in smokers and non-small cell histology, the results of our study do not support the prognostic role of pre-treatment NLR for overall survival in locally advanced and metastatic disease.
Clinico-pathological study of a rare entity-idiopathic calcinosis cutis: A case series
Authors: Mishra Jyotirmayee , Gharei Radhamohan , Nayak Pragnya P , Hembram Prashanta K 
Published: December 2024

Calcinosis cutis is a benign, uncommon disorder that can affect any region of the skin and is typically asymptomatic. It is characterised by several tiny, nodular, painless, hard swellings of different sizes that don't occur in conjunction with any underlying metabolic or systemic disorders. Several hypotheses have been put up to explain the pathophysiology of this illness, however the main argument centres on whether it is completely idiopathic or due to dystrophic calcification. There have only been a few case series of this creature mentioned in the literature.This case series aims to describe an uncommon condition called idiopathic cutaneous calcinosis that may be precisely identified using clinical, pathological, and metabolic correlation.This is a descriptive study to be conducted in Department of Pathology, VIMSAR, Burla, Sambalpur. Data are collected from the FNA records and archived slides of all the cytologically diagnosed cases of idiopathic calcinosis cutis in the Department of Pathology, VIMSAR, Burla within the period from January 2019 to December 2021, including the different demographic variables. All data were analysed and tabulated respectively. Histopathological correlation was done whichever was available. The present study is intended to alert the pathologists to consider calcinosis cutis as a differential diagnosis in any swelling yielding whitish granular material on FNAC as it is a potential mimic of a neoplastic lesions. It also reaffirms that FNAC is a straightforward, quick, and effective method, especially for soft tissue lesions like calcinosis cutis. And in collaboration with serological and biochemical findings can help in effectively manage the patient.
Las otras clínicas. Acompañar prácticas y procesos: del kliné al kiné
Authors: Harguindey María Alicia , Ussher Margarita , Wajnerman Carolina 
Published: December 2024

Este texto surge en el marco de la Carrera de Especialización en Psicología Social Comunitaria del Colegio de Psicólogas y Psicólogos de la Provincia de Buenos Aires (Distrito XIV, Morón). Buscamos producir una revisión discursiva del término clínica, pluralizando sus sentidos, para ampliar su alcance a otras prácticas no reconocidas en los haceres de los equipos territoriales, aunque estén enunciadas en los marcos legales que abogan por una perspectiva de derechos. En esa búsqueda encontramos la necesidad de superar el límite de una única definición y de pasar a pensar clínicas que producen rupturas y se sostienen en posiciones críticas, respecto de aquella nacida con la raíz kliné, la del cuerpo enfermado2 y recostado.
Las clínicas que reconocemos e invitamos a reconocer son aquellas que tienen a la otredad como protagonista y a los cuidados como objetivo, que resisten a lo unívoco, se nutren de la rebeldía y la incomodidad, apuestan a lo agudo de diferentes modos de simbolización en su relación con el otro, haciendo reacción, resonancia y creación, incluyendo el juego, el humor y los lenguajes corporales y saberes culturales diversos. Son clínicas con sensibilidad y que abren la posibilidad de abarcar y conjugarse con la dimensión comunitaria, y que se despliegan en los bordes de la clínica hegemonizada. Clínicas múltiples, participativas, que elegimos llamar cínicas, críticas, perrunas, rizomáticas, que anclan y desbordan sobre distintos suelos, eligiendo también otros modos de narrar y ser narradas.
Arte, Cultura y Salud mental entre Brasil y Argentina. Reflexiones desde la experiencia
Authors: Dri Mariela 
Published: December 2024

En este escrito intentaré conectar experiencias que transité en diferentes momentos históricos buscando dar cuenta de la relevancia de los espacios artísticos y culturales en el campo de la salud mental y específicamente en el proceso de desmanicomialización. Se tomarán registros de una experiencia realizada en un taller de arte durante los años 2014 y 2015 en el Hospital Dr. Alejandro Korn de Melchor Romero (Buenos Aires, Argentina). Luego se recortará una experiencia en el Bloco Carnavalesco “Loucura Suburbana”, del Instituto Municipal “Nise da Silveira” en Río de Janeiro, Brasil, realizada en el año 2022. Por último, finalizaré con algunas reflexiones y propuestas para pensar la política pública en cultura y salud mental desde mi actual participación en el Programa “Buenos Aires Libre de Manicomios” de la Subsecretaría de Salud Mental, Consumos Problemáticos y Violencias en el Ámbito de la Salud.
El objetivo del presente escrito es dar jerarquía a la intersección de los campos de la cultura y la salud mental. Para ello se partirá desde la experiencia para luego desprender de la misma algunos interrogantes y reflexiones que continúen contribuyendo al debate en este sentido. Tomaré dos experiencias centrales, una en Argentina, realizada a poco tiempo de sancionada la Ley Nacional de Salud Mental Nº 26.657, donde los talleres de arte eran muchas veces los únicos espacios desde donde resistir a la lógica manicomial de las instituciones; y otra más reciente en Brasil, donde los dispositivos artísticos dan cuenta de la potencia transformadora de lo cultural, instalándose como espacios clave en los procesos de desmanicomialización.
Finalmente, con estas experiencias como insumo, realizaré algunas reflexiones en relación a la política pública en este encuentro de campos y en clave latinoamericana.
Procesos de atención y cuidado en el campo de la salud mental de infancias en contextos migratorios regionales: un análisis de los discursos de familias migrantes latinoamericanas y de profesionales de la salud mental del sector público estatal en la Ciud
Authors: Poverene Laura 
Published: December 2024

Nuestros escritos conservan marcas de manuscritos previos que, pese a haber podido ser omitidos, atesoran los albores que alumbraron la historia naciente. Mediante la lógica del palimpsesto, resulta sustancial examinar y des/cubrir las huellas que, pese al transcurso del tiempo, continúan ejercitando su presencia inclaudicable y probando quiénes hemos pasado por allí.
Desde la propuesta ética y epistemológica que introduce el concepto de reflexividad, deviene ineludible echar luz sobre aquellas marcas-causas que movilizaron el interés por las temáticas que elegimos abordar. En mi caso, fue la intersección entre la salud mental y las infancias en contextos migratorios.
Las influencias disciplinares como psicóloga, mis inserciones laborales (tanto en organizaciones de la sociedad civil trabajando con personas migrantes y refugiadas, como en equipos de salud mental infanto-juvenil de Hospitales Públicos de la Ciudad Autónoma de Buenos Aires [CABA], a los que acudían numerosas infancias provenientes de países limítrofes), las características que cobró mi socialización científica en el campo interdisciplinar, e incluso, las experiencias migratorias que atravesaron la propia historia familiar, modelaron mi matriz de comprensión de la realidad (Marradi, Archenti y Piovani, 2007).
Eficacia de las fibras de polietileno en dientes tratados endodónticamente. Revisión de la Literatura
Authors: Cajamarca Fárez Adriana Lucía , Matute Bermeo Joseline Marcela , Tamariz Ordóñez Pablo Esteban 
Published: December 2024

Se presenta una revisión bibliográfica no sistemática sobre la eficacia de las fibras de polietileno en dientes tratados endodónticamente, con base en la producción científica disponible entre los años 2016 y 2023, extraída de las bases de datos PubMed y Google Académico. En total, se incluyeron 26 artículos completos. Los resultados de la revisión revelaron que el 59 % de los artículos reportaron resultados superiores de los FRC (fibras de resina compuesta) de polietileno en comparación con otras alternativas, mientras que un 27,3 % no encontró diferencias significativas entre los FRC de polietileno y los FRC de vidrio. Solo un pequeño porcentaje, el 6,9 %, indicó que los FRC de vidrio presentaban mejores características que los de polietileno.

A partir de los hallazgos, se concluye que el uso de fibras de polietileno puede contribuir a mejorar la resistencia de los dientes tratados endodónticamente, especialmente aquellos rehabilitados con restauraciones directas de composite. Estas fibras también pueden tener un efecto positivo sobre la resistencia a la fractura y la dispersión de fuerzas masticatorias. Sin embargo, a pesar de los resultados prometedores, la falta de suficiente información científica y de estudios concluyentes resalta la importancia de continuar evaluando el rendimiento y la eficacia real de las fibras de polietileno en el tratamiento endodóntico para confirmar su aplicabilidad clínica a largo plazo.
Huevecillos de Helmintos: Una validación para su determinación y cuantificación en Aguas, Aguas Residuales y Lodos de Costa Rica
Authors: Alfaro-Arrieta Ernesto , Alfaro-Lara Juan José , Méndez-Araya Johanna , Solís-Calderón Catalina , Vega-Guzmán Ileana 
Published: December 2024

La presencia de huevecillos de helmintos en el agua representa una problemática de salud pública y ambiental, que puede llegar a afectar una gran cantidad de la población. Ante la ausencia de una metodología actualizada y validada y la falta de indicación en las regulaciones de Costa Rica. Se propone una metodología para la identificación de huevecillos de helmintos en aguas, aguas residuales y lodos. Se realizó la validación de la técnica evaluando nueve parámetros de desempeño como: Límites de Detección, Límites de Cuantificación, Repetibilidad, Reproducibilidad, Especificidad, Selectividad, Sensibilidad, Incertidumbre y Veracidad. Se analizaron muestras de cada una de las matrices inoculando un 50% de las mismas con huevecillos de helmintos provenientes de un material de referencia certificado, se optimizaron las metodologías establecidas a través de procesos de sedimentación y centrifugación de la muestra para obtener una recuperación aceptable. Los resultados obtenidos de la validación fueron conformes con respecto a las metodologías de referencia y a lo requerido para el cumplimiento de la legislación nacional al establecer una metodología adecuada para la identificación y cuantificación de huevecillos de helmintos.
Nivel de modernización del Laboratorio Nacional de Aguas a partir de 1997
Authors: Mora-Alvarado Darner 
Published: December 2024

Las instalaciones actuales del Laboratorio Nacional de Aguas (LNA) datan su construcción desde el año 1921. A pesar de las limitaciones en la infraestructura física de la sede del LNA, en este estudio se presenta el nivel de modernización con que se cuenta considerando el equipamiento, recurso humano y los avances comparativos en los procesos de acreditación del sistema de gestión de calidad, las inspecciones y las técnicas analíticas con las normas INTE/ISO/IEC 17025:2017 e INTE/ISO/IEC 17020:2012, a partir de la designación del Laboratorio Central de AyA como Laboratorio Nacional de Aguas, mediante el Decreto Ejecutivo N°26066-S del año 1997.
A novel SNP-based approach for non-invasive prenatal paternity testing using multiplex PCR targeted capture sequencing
Authors: Qu Yiling , Zhang Ranran , Qing Li , Ma Xiaoyan , Chen Anqi , Liang Weibo , Wang Hongyan , Li Chengtao , Zhang Suhua 
Published: December 2024

Objective: To enhance the safety, simplicity, and efficacy of non-invasive prenatal paternity testing, we developed a method based on multiplex PCR targeted capture sequencing technology utilizing single nucleotide polymorphisms (SNPs) as genetic markers.
Method: We screened 627 SNPs from public databases and literature based on specific criteria and population genetic data from 100 unrelated individuals. A total of 15 peripheral blood samples were collected from pregnant women and the suspected father. Paternal alleles were detected and analyzed in the plasma cell-free DNA (cfDNA) of pregnant women, fetal SNP genotypes were obtained, and the combined paternity index (CPI) was calculated for paternity testing.
Results: Biological fathers were accurately determined in all cases, with CPI values ranging from 1.05 × 1014 to 2.03 × 1034, consistent with results obtained using polymerase chain reaction-capillary electrophoresis (PCR-CE) with short tandem repeats. Significant differences in CPI between unrelated males and biological fathers allowed for straightforward exclusion. Even cfDNA from maternal plasma as early as five gestational weeks enabled accurate paternity determination.
Conclusion: This novel approach demonstrates significant improvements by reducing the number of SNPs, streamlining the research procedure, and lowering costs, yielding substantial advancements in non-invasive prenatal paternity testing.
ANALYSIS OF EFFECT WATER REDUCTION AND ABRASION VALUE OF COARSE AGGREGATE PADA BETON BY USING SUPERPLASTICIZER VISCOCRETE 1050 HE
Authors: Prambudi Krisna Varian Ardhika , Prasetia Irfan 
Published: December 2024

With the rapidity of the construction world , the use of materials will also increase, one of which is the increasing use of concrete. One of the developments is to add additives to the concrete dough to be able to achieve the expected results. This study uses Superplasticcizer Viscocrete 1050 HE which is the latest type of output from PT. SIKA has the advantage of being able to reduce water by more than 30%. The discrete content used is 1% of the weight of cement and the water reduction content is 0% to 40%. The results of the concrete compressive strength test were obtained results with the use of Viscocrete 1050 HE 1% with a reduction of water of 35% having a maximum concrete compressive strength value of 40.2 Mpa at the age of 28 days for coarse aggregates that have a low abrasion value (AK1) and of 39.8 Mpa at the age of 28 days for aggregates rough that has a high abrasion value (AK2). Keywords: Water Reduction, Superplasticizer, Abrasion
ANALYSIS OF PARKING SPACE REQUIREMENTS IN PLANNED AREA 3 (KELAYAN PARK) WEST KELAYAN BANJARMASIN
Authors: Rusyda Ayra Faza , Arsyad Muhammad 
Published: December 2024

The Regional Plan is a program from the Ministry to improve the quality of slum settlements in Banjarmasin by transforming the face of the area into the tourism sector. As a tourism sector, Regional Plan 3 is expected to be a place visited by tourists from various regions. The purpose of the study was to determine the capacity of the parking lot, analyze the needs and the appropriate parking service system and predict the need for parking spaces for the next few years. The parameters used are the total number of two-wheeled and four-wheeled vehicles entering and leaving the parking area. As the object of study, the survey was carried out by observing for three days and observing for 5 hours a day. The research shows that the parking capacity requirement in the Kelayan Barat 3 (Taman Kelayan) Plan of Kelayan Barat Banjarmasin is still safe with the intention of not experiencing too much density to accommodate visitor arrivals with the maximum amount of capacity available in the parking area, which is about 55.5 m2 for motorbike parking. Of the available 57 m2 of land, as well as the car park requires 100 m2 of the 112.5 m2 of available land. In comparison, the prediction index for the next five years for two-wheeled vehicles produces a saturation of 101.4%, and for four-wheeled vehicles by 114.2%. Likewise, car parking requires 100 m2 of the available 112.5 m2 of land. Keywords: Parking space capacity
Analysis Of The Influence Of The School Safety Zone (Case Study on Jalan Ahmad Yani SDN 4 Guntung Manggis, Landasan Ulin District, Banjarbaru City)
Authors: Rahman Akhmad Fadqur , Arsyad Muhammad 
Published: December 2024

The School Safety Zone under review is the School Safety Zone on Ahmad Yani street in front of SDN 4 Guntung Manggis, Banjarbaru. The School Safety Zone itself can affect traffic conditions, ranging from volume, speed, and density. The purpose of this study was to determine the effect of the existence of a safe school zone and the absence of a safe school zone and to determine traffic performance on the Ahmad Yani road section which contained the school safety zone area. The research is a field survey to find data on volume, speed, and side resistance. The survey was taken under two conditions, namely the condition under the influence of the School Safety Zone and without the influence of the School Safety Zone. Model Analysis method Greenshield, the Greenberg Model, and the Underwood to determine the capacity on the road section which is supported by daily traffic volume data and vehicle speed to get the density on the road section. From the modeling analysis, the chosen model is the Greenshield model. From the calculation results, the maximum volume decreased by 13.14%, at the average speed decreased by 16.10%, and the maximum density increased by 3.52%. The ITP value is obtained with a V/C ratio at the operational hours of the School Safety Zone, in the area not affected by the School Safety Zone, the DS is 0.49 while in the affected area the School Safety Zone is DS 0.66. Both have an ITP C value which means Stable Flow, but the speed and motion of the vehicle is controlled, the driver is limited in choosing the speed. Keywords: School Safety Zone, Speed Analysis, Greenshield, Road Performance
Time and Cost Analysis of Road Construction Projects Using Earned Value
Authors: Melati Rima , Yuliana Candra 
Published: December 2024

In project implementation, it is very rare to find projects that are carried out according to plan, there are often delays in project implementation that are detrimental, as well as the Jl. Sp. Handil Bakti (Sp. Serapat) – KM.17 (By Pass Banjarmasin). This study examines the progress of work and deviations that occur as well as the factors and impacts of delays. In this study, the Earned Value is used to analyze the progress of work with the amount of cost and time that has been used so that an estimate of the cost needs to be made until the end of project implementation and the possibility of a deviation as well as direct interviews to get the factors and impacts of delays. The results of the analysis using Earned Value from the 1st week to the 20th week, the project duration (ECD) is faster than the plan, which is 110 weeks and the total cost is Rp. 146.063.967.764.75 smaller than the plan of Rp. 158,773,106,401.70. The results of interviews with related parties regarding the factors and impacts of delays were due to bad weather which caused flooding at the beginning of the project implementation so the project design was re-planned. Keywords: Result value method, planned value, earned value, actual cost, delay factor, the impact of delay.