bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustaining the properties of black soil in Central India through crop residue management in a conservation‐agriculture‐based soybean–wheat system
Authors: Yadav Devideen , Vishwakarma Anand Kumar , Sharma Narinder Kumar , Biswas Ashis Kumar , Ojasvi Prabhat Ranjan , Kumar Dinesh , Kumawat Anita , Singh Deepak 
Published: January 2021

AbstractSoybean–wheat cropping system is the most commonly used in the black soil of India which produces enormous amounts of nutrient‐rich residues. However, black soil has some production limitations, such as rapid drying, high bulk density, low nutrients, and poor microbial populations, making it vulnerable to degradation. Optimal retention of soybean and wheat residues in black soil under the zero‐tillage (no‐till) system can improve soil properties and help protect the land from degradation. Thus, the main objective of this study was to test the effect of different levels of soybean and wheat residue retention on the physical, chemical, and biological properties of black soil. Therefore, an experiment was conducted in the zero‐tillagesoybean–wheat system at the Indian Institute of Soil Science, Bhopal, India from 2014 to 2018. In this study, the effect of four levels of soybean and wheat residue retention (no residue, 30, 60, and 90%) on soil properties was evaluated. Results revealed that soil organic carbon (C) significantly increased from 0.67 to 1.0% in 5 years through 90% residue retention. Retaining 90% (7.0 t) of soybean residue added 2.9 t C, 197.3 kg nitrogen (N), 32.4 kg phosphorus (P), and 89.7 kg potassium (K) in 5 years, while 6.2 t C, 85.7 kg N, 15.3 kg P, and 232.2 kg K were added through 90% (13.8 t) wheat residue during the same period. Different pools of soil C (oxidizable, labile, and particulate organic matter (OM)‐carbon), soil OM, soil moisture, soil porosity, available nutrients, and bacterial, fungal, and actinomycetes count was significantly enhanced due to retention of 90% residue over 60 and 30%. It was observed that retention of 90% soybean and wheat residues (7.0 and 13.8 t ha−1, respectively) significantly improved the physical, chemical, and biological properties of black soil in 5 years, therefore protected the soil from degradation.
Building resilience through cooperation: Two case studies
Authors: Brown Josh , Jones Phill , Meadows Alice , Murphy Fiona 
Published: January 2021

Key points
There is evidence that cooperatives provide greater resilience in times of crisis than conventional enterprises.
Cooperatives subscribe to seven values associated with economic and governance participation, as well as equality and concern for community.
We present two case studies, one well established (Crossref) and one new (the UK National Research Identifier Coordinating Committee), that have adopted some cooperative principles.
There is a strong push towards greater cooperation in the scholarly communications sector.
There is enough evidence from our own sector and the wider socio‐economic landscape to justify prioritizing cooperation and cooperative values in our common endeavours in coming years.
Publishing during a pandemic: Resilience and change
Authors: O'Connor Niamh 
Published: January 2021

Key points
The scholarly publishing industry must be prepared to step back, consider our value, reset our relationships, and be prepared to accept and embrace real change.
Three areas of focus during these times should be (1) the importance of community; (2) racism, bias, and structural inequities; and (3) openness, transparency, and trust.
We need to recognize the importance of the humanities and social sciences, as well as of science, technology, and medicine in addressing the impacts of the pandemic.
Cost‐Effectiveness of Primary Liver Transplantation Versus Hepatoportoenterostomy in the Management of Biliary Atresia in the United States
Authors: Raghu Vikram K. , Squires James E. , Mogul Douglas B. , Squires Robert H. , McKiernan Patrick J. , Mazariegos George V. , Smith Kenneth J. 
Published: January 2021

Biliary atresia (BA) is the leading indication to perform a pediatric liver transplantation (LT). Timely hepatoportoenterostomy (HPE) attempts to interrupt the natural history and allow for enteric bile flow; however, most patients who are treated with HPE require LT by the age of 10 years. We determined the cost‐effectiveness of foregoing HPE to perform primary LT (pLT) in children with BA compared with standard‐of‐care HPE management. A Markov model was developed to simulate BA treatment over 10 years. Costs were measured in 2018 US dollars and effectiveness in life‐years (LYs). The primary outcome was incremental cost‐effectiveness ratio (ICER) between treatments. Model parameters were derived from the literature. In the base model, we assumed similar LT outcomes after HPE and pLT. Sensitivity analyses on all model parameters were performed, including a scenario in which pLT led to 100% patient and graft survival after LT. Children undergoing HPE accumulated $316,692 in costs and 8.17 LYs per patient. Children undergoing pLT accumulated $458,059 in costs and 8.24 LYs per patient, costing $1,869,164 per LY gained compared with HPE. With parameter variation over plausible ranges, only post‐HPE and post‐LT costs reduced the ICER below a typical threshold of $100,000 per LY gained. On probabilistic sensitivity analysis, 93% of iterations favored HPE at that threshold. With 100% patient and graft survival after pLT, pLT cost $283,478 per LY gained. HPE is more economically favorable than pLT for BA. pLT is unfavorable even with no graft or patient loss. The ability to predict those patients who may experience high costs after HPE or low costs after LT may help identify those patients for whom pLT could be considered.
Green Fabrication of Chitin/Chitosan Composite Hydrogels and Their Potential Applications
Authors: Xu Huan , Zhang Li , Zhang Hongli , Luo Jie , Gao Xiaofang 
Published: January 2021

AbstractChitin is the second most abundant natural polysaccharide with biocompatibility and bioactivity. Aqueous KOH/urea solution is reported for rapid dissolution of chitin, therefore providing a greener and more efficient avenue to fabricate chitin‐based functional materials. Chitosan is the most important derivative of chitin with the acetylation degree lower than 60%. Herein, novel chitin/chitosan composite hydrogels are fabricated from the green and highly efficient KOH/urea aqueous system for the first time. Both chitin and chitosan are dissolved in aqueous KOH/urea solutions, then cross‐linked by epichlorohydrin to form bulk chitin/chitosan composite hydrogels (CCGEL). The structural, thermal, mechanical, and swelling properties of CCGEL are thoroughly studied. The cell studies show that NIH‐3T3 cells self‐assemble to form regular 3D multicellular spheroids on the CCGEL samples with high viability. L929 cells proliferate and intend to form cell aggregates, and the size of the cell aggregates becomes greater with the increase of chitosan loading. Additionally, the CCGEL samples exhibit antibacterial activities. Thus, this pioneering work has provided crucial information for novel chitin/chitosan composite materials constructed via the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions, and presented their potential applications in the cell culture and antibacterial fields.
Special subsets of the generalized Cantor space and generalized Baire space
Authors: Korch Michał , Weiss Tomasz 
Published: January 2021

AbstractIn this paper, we are interested in parallels to the classical notions of special subsets in defined in the generalized Cantor and Baire spaces (2κ and ). We consider generalizations of the well‐known classes of special subsets, like Lusin sets, strongly null sets, concentrated sets, perfectly meagre sets, σ‐sets, γ‐sets, sets with the Menger, the Rothberger, or the Hurewicz property, but also of some less‐know classes like X‐small sets, meagre additive sets, Ramsey null sets, Marczewski, Silver, Miller, and Laver‐null sets. We notice that many classical theorems regarding these classes can be relatively easy generalized to higher cardinals although sometimes with some additional assumptions. This paper serves as a catalogue of such results along with some other generalizations and open problems.
Striatal Dopamine Induced ERK Phosphorylation Is Altered in Mouse Models of Monogenic Dystonia
Authors: Melis Chiara , Beauvais Genevieve , Muntean Brian S. , Cirnaru Maria‐Daniela , Otrimski Garrett , Creus‐Muncunill Jordi , Martemyanov Kirill A. , Gonzalez‐Alegre Pedro , Ehrlich Michelle E. 
Published: January 2021

ABSTRACTBackgroundSimilar to some monogenic forms of dystonia, levodopa‐induced dyskinesia is a hyperkinetic movement disorder with abnormal nigrostriatal dopaminergic neurotransmission. Molecularly, it is characterized by hyper‐induction of phosphorylation of extracellular signal‐related kinase in response to dopamine in medium spiny neurons of the direct pathway.ObjectivesThe objective of this study was to determine if mouse models of monogenic dystonia exhibit molecular features of levodopa‐induced dyskinesia.MethodsWestern blotting and quantitative immunofluorescence was used to assay baseline and/or dopamine‐induced levels of the phosphorylated kinase in the striatum in mouse models of DYT1, DYT6, and DYT25 expressing a reporter in dopamine D1 receptor‐expressing projection neurons. Cyclic adenosine monophosphate (cAMP) immunoassay and adenylyl cyclase activity assays were also performed.ResultsIn DYT1 and DYT6 models, blocking dopamine reuptake with cocaine leads to enhanced extracellular signal‐related kinase phosphorylation in dorsomedial striatal medium spiny neurons in the direct pathway, which is abolished by pretreatment with the N‐methyl‐d‐aspartate antagonist MK‐801. Phosphorylation is decreased in a model of DYT25. Levels of basal and stimulated cAMP and adenylyl cyclase activity were normal in the DYT1 and DYT6 mice and decreased in the DYT25 mice. Oxotremorine induced increased abnormal movements in the DYT1 knock‐in mice.ConclusionsThe increased dopamine induction of extracellular signal‐related kinase phosphorylation in 2 genetic types of dystonia, similar to what occurs in levodopa‐induced dyskinesia, and its decrease in a third, suggests that abnormal signal transduction in response to dopamine in the postsynaptic nigrostriatal pathway might be a point of convergence for dystonia and other hyperkinetic movement disorders, potentially offering common therapeutic targets. © 2021 International Parkinson and Movement Disorder Society
Involvement of Autophagy in Levodopa‐Induced Dyskinesia
Authors: Feyder Michael , Plewnia Carina , Lieberman Ori J. , Spigolon Giada , Piccin Alessandro , Urbina Lidia , Dehay Benjamin , Li Qin , Nilsson Per , Altun Mikael , Santini Emanuela , Sulzer David , Bezard Erwan , Borgkvist Anders , Fisone Gilberto 
Published: January 2021

AbstractBackgroundAutophagy is intensively studied in cancer, metabolic and neurodegenerative diseases, but little is known about its role in pathological conditions linked to altered neurotransmission. We examined the involvement of autophagy in levodopa (l‐dopa)‐induced dyskinesia, a frequent motor complication developed in response to standard dopamine replacement therapy in parkinsonian patients.MethodsWe used mouse and non‐human primate models of Parkinson's disease to examine changes in autophagy associated with chronic l‐dopa administration and to establish a causative link between impaired autophagy and dyskinesia.ResultsWe found that l‐dopa‐induced dyskinesia is associated with accumulation of the autophagy‐specific substrate p62, a marker of autophagy deficiency. Increased p62 was observed in a subset of projection neurons located in the striatum and depended on l‐dopa‐mediated activation of dopamine D1 receptors, and mammalian target of rapamycin. Inhibition of mammalian target of rapamycin complex 1 with rapamycin counteracted the impairment of autophagy produced by l‐dopa, and reduced dyskinesia. The anti‐dyskinetic effect of rapamycin was lost when autophagy was constitutively suppressed in D1 receptor‐expressing striatal neurons, through inactivation of the autophagy‐related gene protein 7.ConclusionsThese findings indicate that augmented responsiveness at D1 receptors leads to dysregulated autophagy, and results in the emergence of l‐dopa‐induced dyskinesia. They further suggest the enhancement of autophagy as a therapeutic strategy against dyskinesia. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
Recent progress toward highly efficient tin‐based perovskite (ASnX3) solar cells
Authors: Zhu Mingzhe , Cao Guorui , Zhou Zhongmin 
Published: January 2021

AbstractRecently, lead halide perovskites have attracted great attention in photovoltaic field because of high power conversion efficiency. However, the toxicity of lead in perovskite can result in environment issues, which are the major challenge for commercial application. In this context, environmentally friendly lead‐free perovskite alternatives are highly desired. Bearing excellent photophysical and electronic properties, tin‐perovskites (ASnX3) are the most promising alternative. In reality, extensive efforts have been committed to the development of Sn‐based perovskite solar cells. In this review, we summarized the theoretical fundamentals of Sn‐based perovskites, including lattice, phases, molecular orbital, redox property, and defects. Then varieties of tactics to improve devices performance were detailed reviewed. Finally, perspectives on further research directions in improving Sn‐based solar cells performance are presented.
Serum metabolic signature of binge‐like palatable food consumption in female rats by nuclear magnetic resonance spectroscopy
Authors: Cifani Carlo , Alboni Silvia , Mucci Adele , Benatti Cristina , Botticelli Luca , Brunello Nicoletta , Micioni Di Bonaventura Maria Vittoria , Righi Valeria 
Published: January 2021

AbstractMaladaptive eating behavior is a growing public health problem and compulsively eating excessive food in a short time, or binge eating, is a key symptom of many eating disorders. In order to investigate the binge‐like eating behavior in female rats, induced by intermittent food restrictions/refeeding and frustration stress, we analyzed for the first time the metabolic profile obtained from serum of rats, through nuclear magnetic resonance (NMR) spectroscopy. In this experimental protocol, rats were exposed to chow food restricting/refeeding and frustration stress manipulation. This stress procedure consists of 15 min exposure to the odor and sight of a familiar chocolate paste, without access to it, just before offering the palatable food. In this model, a “binge‐eating episode” was considered the significantly higher palatable food consumption within 2 h in restricted and stressed rats (R + S) than in the other three experimental groups: rats with no food restriction and no stress (NR + NS), only stressed rats (NR + S) or only restricted rats (R + NS). Serum samples from these four different rat groups were collected. The statistical analysis of the 1H NMR spectral profiles of the four sets of samples pointed to O‐ and N‐acetyl glycoproteins as the main biomarkers for the discrimination of restriction effects. Other metabolites, such as threonine, glycine, glutamine, acetate, pyruvate and lactate, showed trends that may be useful to understand metabolic pathways involved in eating disorders. This study suggested that NMR‐based metabolomics is a suitable approach to detect biomarkers related to binge‐eating behavior.
Electroelastic analysis of two‐dimensional ultrathin layered piezoelectric films by an advanced boundary element method
Authors: Gu Yan , Sun Linlin 
Published: January 2021

AbstractThe aim of the present study is to present an effect boundary element method (BEM) for electroelastic analysis of ultrathin piezoelectric films/coatings. The troublesome nearly singular integrals, which are crucial in applying the BEM for thin‐structural problems, are calculated accurately by using a nonlinear coordinate transformation method. The advanced BEM presented requires no remeshing procedure regardless of the thickness of the thin structure. Promising BEM results with only a small number of boundary elements can be achieved with the relative thickness of the thin piezoelectric film is as small as 10−8, which is sufficient for modeling many ultrathin piezoelectric films as used in smart materials and micro‐electro‐mechanical systems. The present BEM procedure with thin‐body capabilities is also extended to general multidomain problems and used to model ultrathin coating/substrate piezoelectric structures. The influence of relative layer‐to‐substrate thickness and the bimaterial mismatch parameters are carefully investigated. Excellent agreement between numerical and theoretical solutions has been demonstrated.
Can Some Anticancer Treatments Preserve the Ovarian Reserve?
Authors: Vallet Nicolas , Boissel Nicolas , Elefant Elisabeth , Chevillon Florian , Pasquer Hélène , Calvo Charlotte , Dhedin Nathalie , Poirot Catherine 
Published: January 2021

Abstract

Background
Preventing premature ovarian failure (POF) is a major challenge in oncology. With conventional regimens, cytotoxicity-associated POF involves primordial follicles (PF) pool depletion by apoptosis or overactivation mechanisms, notably mediated by the ABL/TAp63 and PI3K/Akt/mTOR pathways. New anticancer treatments have been designed to target pathways implicated in tumor growth. Although concerns regarding fertility arise with these targeted therapies, we hypothesized that targeted therapies may exert off-tumor effects on PF that might delay POF. We provide an overview of evidence concerning these off-tumor effects on PF. Limitations and future potential implications of these findings are discussed.

Design
PubMed was searched by combining Boolean operators with the following keywords: fertility, ovarian, follicle, anti-tumoral, cancer, targeted, cytotoxic, and chemotherapy.

Results
Cisplatin-related PF apoptosis via the ABL/TAp63 pathway was targeted with a tyrosine kinase inhibitor, imatinib, in mice, but effects were recently challenged by findings on human ovarian xenografts in mice. In cyclophosphamide-treated mice, PI3K/Akt/mTOR pathway inhibition with mTOR inhibitors and AS101 preserved the PF pool. Proteasome and GSK3 inhibitors were evaluated for direct and indirect follicle DNA damage prevention. Surprisingly, evidence for cytotoxic drug association with PF pool preservation was found. We also describe selected non-anticancer molecules that may minimize gonadotoxicity.

Conclusion
Not all anticancer treatments are associated with POF, particularly since the advent of targeted therapies. The feasibility of associating a protective drug targeting PF exhaustion mechanisms with cytotoxic treatments should be evaluated, as a way of decreasing the need for conventional fertility preservation techniques. Further evaluations are required for transfer into clinical practice.

Implications for Practice
Anticancer therapies are associated with infertility in 10%–70% of patients, which is the result of primordial follicles pool depletion. Alone or associated with gonadotoxic treatments, some targeted therapies may exert favorable off-targets effects on the primordial follicle pool by slowing down their exhaustion. Current evidence of these effects relies on murine models or human in vitro models. Evaluation of these protective strategies in humans is challenging; however, if these results are confirmed with clinical and biological data, it not only could be a new approach to female fertility preservation but also would change standard fertility strategies.
Factors associated with the use of the prescription monitoring program by prescribers and pharmacists in Texas
Authors: Thornton James Douglas , Varisco Tyler J. , Downs Callie G. 
Published: January 2021

AbstractPurposeTo describe Texas Prescription Monitoring Program (PMP) use and identify predictors of PMP query for opioid and benzodiazepine prescriptions by prescribers and pharmacists.MethodsDispensation and query records from the Texas PMP for opioid and benzodiazepine medications dispensed between October 1, 2016 and December 31, 2018 were linked using common patient identifiers. Autoregressive linear regression was used to assess trends in utilization. Hierarchical logistic models were specified to identify factors associated with provider and pharmacist query of opioid and benzodiazepine prescriptions.ResultsDespite a significant increase in the total number of pharmacists (β = 169.85, p < 0.0001) and prescribers (β = 301.59, p < 0.0001) who used the PMP every month, the ratio of active to registered pharmacists (β = −0.0001, p = 0.75) and prescribers (β = −0.0015, p = 0.10) did not change. Pharmacists and prescribers were significantly more likely to query opioid and benzodiazepine prescriptions of 14 days or more, and those issued to patients new to their practice. Pharmacists were most likely to query opioid prescriptions for oxycodone (aOR = 4.51, 95%CI = 4.42–4.60) and prescribers were most likely to query prescriptions for buprenorphine (aOR = 2.24, 95%CI = 2.15–2.35) compared to codeine.ConclusionChanges in PMP utilization between October 2016 and December 2018 were driven by increasing registration, not increasing frequency of use among registered users. Use of the PMP is inconsistent and dependent upon patient characteristics thus limiting the utility of the PMP as a decision support tool. These results support the need for policy mandating PMP use in Texas and provide a useful baseline and framework to evaluate the effectiveness of mandate implementation.
Treatment Recommendations for Phantom Limb Pain in People with Amputations: An Expert Consensus Delphi Study
Authors: Limakatso Katleho , Parker Romy 
Published: January 2021

AbstractBackgroundPhantom limb pain (PLP) is common and often accompanied by serious suffering. Current systematic‐review evidence suggests that recommended treatments are no more effective than placebo for reducing PLP. Given the difficulty in conducting a meta‐analysis for nonpharmacological treatments and the weak evidence for pharmacological treatments for PLP, consensus on the first‐line management of PLP needs to be reached using alternative methods.ObjectiveTo reach expert consensus and make recommendations on the effective management of PLP.DesignA three‐round Delphi design was used.SettingThe study was conducted using e‐mail and Google survey tool as the main methods of communication and providing feedback.ParticipantsThe study included 27 clinicians and researchers from various health disciplines who are experts in PLP management.MethodData were collected using three sequential rounds of anonymous online questionnaires where experts proposed and ranked the treatments for PLP. A consensus was reached on the treatments that were endorsed by 50% or more of the experts.ResultsThirty‐seven treatments were proposed for the management of PLP at the beginning of the study. Consensus was reached on seven treatments that were considered effective for managing PLP and on two treatments that were considered ineffective. Graded motor imagery, mirror therapy, amitriptyline, sensory discrimination training, and use of a functional prosthesis were endorsed by most experts because of the available backing scientific evidence and their reported efficacy in clinical practice. Cognitive behavioral therapy and virtual reality training were endorsed by most experts because of their reported efficacy in clinical practice despite indicating a dearth of scientific evidence to support their ranking. Citalopram and dorsal root ganglion pulsed radiofrequency were rejected owing to a lack of relevant scientific evidence.ConclusionThe results of this study suggest that the nonpharmacological treatments endorsed in this study may have an important role in the management of PLP.