bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors to consider when designing post-hospital interventions to support critical illness recovery: Systematic review and qualitative evidence synthesis
Authors: Stewart Jonathan , Pauley Ellen , Wilson Danielle , Bradley Judy , Hart Nigel , McAuley Danny 
Published: January 2025

Background: Survivors of intensive care unit (ICU) admission experience significant deficits in health-related quality of life due to long-term physical, psychological, and cognitive sequelae of critical illness, which may persist for many years. There has been a proliferation of post-hospital interventions in recent years which aim to support ICU-survivors, however there is currently limited evidence to inform optimal approach. We therefore aimed to synthesise factors which impacted the implementation of these interventions from the perspective of healthcare providers, patients, and their carers, and to compare different intervention designs. Methods: We conducted a systematic review and synthesis of qualitative evidence using four databases (MEDLINE, EMBASE, CINAHL and Web of Science) which were searched from inception to May 2024. The extraction and synthesis of factors which impacted intervention implementation was informed by the domains of the Consolidated Framework for Implementation Research (CFIR) and Template for Intervention Description and Replication (TIDieR) checklist. Results: Thirty-seven studies were included, reporting on a range of interventions including follow-up clinics and rehabilitation programmes. We identified some overarching principles and specific intervention component and design factors which may support in the design of future strategies to improve outcomes for ICU survivors. For each intervention characteristic, various patient, staff, and setting factors were found to impact implementation. Considering how the intervention will rely on and integrate with existing outpatient and community resources is likely to be important. Conclusion: This review provides a framework to future research examining the optimal approach to supporting ICU survivor recovery following hospital discharge.
Efficacy and safety of dual-targeted therapy for inflammatory bowel disease: a retrospective multicenter study in China
Authors: Jin Xiuxiu , Sun Kefang , Wang Liying , Shen Haiyan , Ma Dan , Shen Tejia , Chen Chunxiao , Li Lan 
Published: January 2025

Background: Treatment options for patients with refractory inflammatory bowel disease (IBD) or concomitant IBD and extraintestinal manifestations (EIM) are often limited. Objective: This study aimed to examine the efficacy and safety of combining biologics or small molecules in patients with refractory IBD, active EIM, or active immune-mediated inflammatory disease (IMID). Design: This was a retrospective and multicenter study. Methods: We retrospectively collected demographics and disease characteristics from 47 patients with IBD who received dual-targeted therapy in 3 hospitals from January 2022 to June 2024. The primary endpoint was clinical remission based on the Harvey–Bradshaw index or patient-reported outcome 2 after at least 4 months of combination therapy. The secondary endpoints included clinical response, endoscopic response, and endoscopic remission, as well as all adverse events that occurred within the period of combination therapy. Results: In total, 47 IBD patients including 37 with refractory IBD, 5 with active EIM, and 5 with active IMID received dual-targeted therapy, of which 37 achieved clinical response (78.7%) and 27 achieved clinical remission (57.4%) at a median follow-up time of 13.0 months. Among these 47 patients, 29 patients underwent endoscopic follow-up, of which 15 (51.7%) achieved endoscopic response and 8 (27.6%) achieved endoscopic remission at a median follow-up time of 9.0 months. Mild and moderate adverse events were reported in 17 (36.2%) patients within the period of combination therapy, and serious adverse events requiring hospitalization occurred in 1 patient (2.1%). Conclusion: The combination therapy of biologics and small molecules for refractory IBD or those with concomitant EIM/IMID is effective and safe.
Feelings About Intercultural Development: A Review of Research on International Students’ Intercultural Adjustment Experiences From an Emotion Perspective
Authors: Zheng (郑维佳) Weijia 
Published: January 2025

Purpose This article presents a critical review of the theoretical and empirical research on international students’ intercultural adjustment experiences from an emotion perspective. Design/Approach/Methods Existing studies are reviewed and analyzed by comparing their underlying approaches of conceptualizing and analyzing emotion. Findings The findings suggest that existing studies have gradually extended research horizons, from detecting and addressing the problematic nature of emotion, to uncovering and promoting its potential in personal development, and finally toward an emerging trend of acknowledging and embracing the dialectics and sociocultural complexities of emotional adjustment. A more inclusive research agenda is essential to grasp the individual uniqueness, social interactivity, and multiple facets of real-life emotional intercultural adjustment phenomena, thereby expanding the boundaries of existing research and strengthening its potential to understand and guide international educational practices. Originality/Value This study analyzes the changes in the research approach of emotional intercultural adjustment from a historical and macro perspective. The review proposes the importance of a holistic, time- and context-based view in understanding real-life emotional intercultural adjustment phenomena to empower international students and promote meaningful social transformation in an era of local and global uncertainties.
Hyperoxia-activated Nrf2 regulates ferroptosis in intestinal epithelial cells and intervenes in inflammatory reaction through COX-2/PGE2/EP2 pathway
Authors: Liu Yanping , Li Tianming , Niu Changping , Yuan Zhengwei , Sun Siyu , Liu Dongyan 
Published: January 2025

AbstractThe lack of knowledge about the mechanism of hyperoxia-induced intestinal injury has attracted considerable attention, due to the potential for this condition to cause neonatal complications. This study aimed to explore the relationship between hyperoxia-induced oxidative damage and ferroptosis in intestinal tissue and investigate the mechanism by which hyperoxia regulates inflammation through ferroptosis. The study systematically evaluated the effects of hyperoxia on oxidative stress, mitochondrial damage, ferroptosis, and inflammation of intestinal epithelial cells both in vitro and in vivo. The results showed that ferroptosis was involved in intestinal oxidative damage caused by hyperoxia and was regulated by Nrf2. Moreover, hyperoxia-induced oxidative damage regulated inflammation through ferroptosis by upregulating the COX-2/PGE2/EP2 signaling pathway. These findings have important implications for future clinical prevention and therapeutic approaches to neonatal organ injury caused by hyperoxia treatment.
Transcriptome and DNA methylation profiling during the NSN to SN transition in mouse oocytes
Authors: Demond Hannah , Khan Soumen , Castillo-Fernandez Juan , Hanna Courtney W. , Kelsey Gavin 
Published: January 2025

Abstract
Background
During the latter stages of their development, mammalian oocytes under dramatic chromatin reconfiguration, transitioning from a non-surrounded nucleolus (NSN) to a surrounded nucleolus (SN) stage, and concomitant transcriptional silencing. Although the NSN-SN transition is known to be essential for developmental competence of the oocyte, less is known about the accompanying molecular changes. Here we examine the changes in the transcriptome and DNA methylation during the NSN to SN transition in mouse oocytes.

Results
To study the transcriptome and DNA methylation dynamics during the NSN to SN transition, we used single-cell (sc)M&T-seq to generate scRNA-seq and sc-bisulphite-seq (scBS-seq) data from GV oocytes classified as NSN or SN by Hoechst staining of their nuclei. Transcriptome analysis showed a lower number of detected transcripts in SN compared with NSN oocytes as well as downregulation of 576 genes, which were enriched for processes related to mRNA processing. We used the transcriptome data to generate a classifier that can infer chromatin stage in scRNA-seq datasets. The classifier was successfully tested in multiple published datasets of mouse models with a known skew in NSN: SN ratios. Analysis of the scBS-seq data showed increased DNA methylation in SN compared to NSN oocytes, which was most pronounced in regions with intermediate levels of methylation. Overlap with chromatin immunoprecipitation and sequencing (ChIP-seq) data for the histone modifications H3K36me3, H3K4me3 and H3K27me3 showed that regions gaining methylation in SN oocytes are enriched for overlapping H3K36me3 and H3K27me3, which is an unusual combination, as these marks do not typically coincide.

Conclusions
We characterise the transcriptome and DNA methylation changes accompanying the NSN-SN transition in mouse oocytes. We develop a classifier that can be used to infer chromatin status in single-cell or bulk RNA-seq data, enabling identification of altered chromatin transition in genetic knock-outs, and a quality control to identify skewed NSN-SN proportions that could otherwise confound differential gene expression analysis. We identify late-methylating regions in SN oocytes that are associated with an unusual combination of chromatin modifications, which may be regions with high chromatin plasticity and transitioning between H3K27me3 and H3K36me3, or reflect heterogeneity on a single-cell level.
Population structure and genetic diversity of Toona sinensis revealed by whole-genome resequencing
Authors: Wang Lei , Lu Chang , Bao Zhi-Gang , Li Meng , Wu Fusheng , Lu Yi-Zeng , Tong Bo-Qiang , Yu Mei , Zhao Yong-Jun 
Published: January 2025

Abstract
Objectives
Toona sinensis, commonly known as Chinese toon, is a perennial woody plant with significant economic and ecological importance. This study employed whole-genome resequencing of 180 T. sinensis samples collected from Shandong to analyze genetic variation and diversity, ultimately identifying 18,231 high-quality SNPs after rigorous quality control and linkage disequilibrium pruning. This comprehensive genomic resource provides novel insights into the genetic architecture of T. sinensis, facilitating the elucidation of population structure and supporting future breeding programs.

Data description
We performed whole-genome resequencing on 180 Toona sinensis samples, generating 1170.26 Gbp of clean data with a Q30 percentage of 93.69%. The average alignment rate to the reference genome was 96.72%, with an average coverage depth of 8 × and a genome coverage of 88.71%. Following data quality control and alignment, we performed SNP calling and filtering to identify high-quality SNPs across all samples. Population structure analyses were then conducted using the identified SNPs, including principal component analysis (PCA), structure analysis, and phylogenetic tree construction. These comprehensive analyses provide a foundation for understanding the genetic diversity and evolutionary dynamics of T. sinensis.
Risk factors for bloodstream infection in COVID-19 patients in intensive care units: a systematic review and meta-analysis
Authors: Wang Jun , Jiang Ting 
Published: January 2025

Abstract
Background
Risk factors for bloodstream infection in patients with COVID-19 in the intensive care unit (ICU) remain unclear. The purpose of this systematic review was to study the risk factors for BSI in patients admitted to ICUs for COVID-19.

Methods
A systematic search was performed on PubMed, EMBASE, Cochrane Library, and Web of Science up to July 2024. Data were reported as combined odds ratio (OR) for categorical variables and weighted mean difference (WMD) for continuous variables.

Results
6914 studies were retrieved, of which 55 were included in the meta-analysis. Men (OR = 1.28, 95% CI: 1.10–1.50, P = 0.006), high SAPS II score (WMD = 6.43, 95% CI: 0.23–12.63, P = 0.042), diabetes (OR = 1.34, 95% CI: 1.04–1.73, P = 0.022), tracheal intubation (OR = 8.68, 95% CI: 4.68–16.08, P < 0.001), mechanical ventilation (OR = 22.00, 95% CI: 3.77-128.328, P < 0.001), ECMO (OR = 2.70, 95% CI: 1.17–6.26, P = 0.020), central venous cannulation (OR = 9.33, 95% CI: 3.06–28.43, P < 0.001), prolonged ICU stay (WMD = 10.37, 95% CI: 9.29–11.44, P < 0.001), methylprednisolone use (OR = 2.24, 95% CI: 1.24–4.04, P = 0.008), and the combination of methylprednisolone and Tocilizumab (OR = 4.54, 95% CI: 1.09–18.88, P = 0.037) were risk factors for ICU-BSI in COVID-19 patients.

Conclusion
We identified 10 risk factors for ICU-BSI in COVID-19 patients. In future studies, these factors can be combined to establish a more comprehensive and accurate prediction model for ICU-BSI in COVID-19 patients. Targeted measures can be taken earlier to control BSI.
Is it possible for parents to endure a stillbirth? Initial experiences, perceptions and strategies: individual in-depth interviews in Sweden 2021–2023
Authors: Höglund Berit , Hildingsson Ingegerd 
Published: January 2025

Abstract
Background
Stillbirth occurs at a rate of 3.0 per thousand in Sweden. However, few studies have focused on the initial experiences of parents facing a stillbirth. The aim of this qualitative study is to deepen and broadly explore parents’ initial experiences, perceptions, internal processes and strategies from the moment of suspicion or awareness of stillbirth until one month after the event.

Methods
Ten individual in-depth interviews were conducted between 2021 and 2023, and data were evaluated using thematic network analysis.

Results
Two key themes emerged: ‘Following the journey – from suspicion to acceptance’ and ‘Support, structured activities and processes after stillbirth’. These themes captured the significant consequences of a sudden, unexpected and devastating end to pregnancy. The suspicion and eventual diagnosis of stillbirth were initially associated with sudden discomfort, fear, overwhelming grief, and intense pain. Nevertheless, a vaginal birth was regarded as the optimal mode of delivery for both physical and emotional wellbeing. Caring for the stillborn baby through physical proximity for an extended period of time helped parents comprehend and cope with their grief, while also affirming their sense of parenthood.

Conclusions
This study sheds light on the profound and devastating impact of stillbirth on parents who are confronted with the loss of their long-awaited and cherished baby. The intense grief and pain experienced by parents during the first month after stillbirth were described as an ongoing heavy burden, persisting day and night, and reflected in poor/very poor mental health. Despite the immense challenges faced by parents, the study highlights the importance of developing individual coping strategies to deal with this tragic and irreversible life-changing event.
Identifying psychosocial predictors and developing a risk score for preterm birth among Kenyan pregnant women
Authors: Larsen Anna , Pintye Jillian , Abuna Felix , Dettinger Julia C. , Gomez Laurén , Marwa Mary M. , Ngumbau Nancy , Odhiambo Ben , Richardson Barbra A. , Watoyi Salphine , Stern Joshua , Kinuthia John , John-Stewart Grace 
Published: January 2025

Abstract
Background
Preterm birth (PTB) is a leading cause of neonatal mortality, particularly in sub-Saharan Africa where 40% of global neonatal deaths occur. We identified and combined demographic, clinical, and psychosocial correlates of PTB among Kenyan women to develop a risk score.

Methods
We used data from a prospective study enrolling HIV-negative women from 20 antenatal clinics in Western Kenya (NCT03070600). Depressive symptoms were assessed by study nurses using the Center for Epidemiologic Studies Depression Scale (CESD-10), intimate partner violence (IPV) with the Hurt, Insult, Threaten, Scream scale (HITS), and social support using the Medical Outcomes Survey scale (MOS-SSS). Predictors of PTB (birth < 37 weeks gestation) were identified using multivariable Cox proportional hazards models, clustered by facility. We used stratified k-fold cross-validation methods for risk score derivation and validation. Area under the receiver operating characteristic curve (AUROC) was used to evaluate discrimination of the risk score and Brier score for calibration.

Results
Among 4084 women, 19% had PTB (incidence rate: 70.9 PTB per 100 fetus-years (f-yrs)). Predictors of PTB included being unmarried (HR:1.29, 95% CI:1.08–1.54), lower education (years) (HR:0.97, 95% CI:0.94–0.99), IPV (HITS score ≥ 5, HR:1.28, 95% CI:0.98–1.68), higher CESD-10 score (HR:1.02, 95% CI:0.99–1.04), lower social support score (HR:0.99, 95% CI:0.97–1.01), and mild-to-severe depressive symptoms (CESD-10 score ≥ 5, HR:1.46, 95% CI:1.07–1.99). The final risk score included being unmarried, social support score, IPV, and MSD. The risk score had modest discrimination between PTB and term deliveries (AUROC:0.56, 95% CI:0.54–0.58), and Brier Score was 0.4672. Women considered “high risk” for PTB (optimal risk score cut-point) had 40% higher risk of PTB (83.6 cases per 100 f-yrs) than “low risk” women (59.6 cases per 100 f-ys; HR:1.6, 95% CI:1.2–1.7, p < 0.001).

Conclusion
A fifth of pregnancies were PTB in this large multi-site cohort; PTB was associated with several social factors amenable to intervention. Combining these factors in a risk score did not predict PTB, reflecting the multifactorial nature of PTB and need to include other unmeasured factors. However, our findings suggest PTB risk could be better understood by integrating mental health and support services into routine antenatal care.
Correlates of condom use among school-going Thai adolescents: the critical role of bullying victimizations
Authors: Dadras Omid 
Published: January 2025

Abstract
Background
Adolescents face numerous challenges that influence their sexual behaviors. Among these, bullying victimization is a critical yet understudied factor that may impact engagement in unprotected sex. This study investigated the correlates of condom use among school-going Thai adolescents, with a main focus on bullying victimization.

Methods
This study is a secondary analysis of the Global School-based Student Health Survey (GSHS) conducted in 2021 among a nationally representative sample of students in grades 7–12 in Thailand. The analysis included all the sexually active students with condom use in the last sex as the main outcome variable. Bivariate binary logistic regression analysis was used to examine the odds of using condom across various explanatory variables. Additional adjusted logistic regression models were constructed to examine the association between bullying experiences and condom use while controlling for the potential confounding effect of other explanatory variables.

Results
Among sexually active participants, 416 (69%) reported using condoms in their last sex and more than half of them reported bullying experiences. Besides bullying, this study identifies several factors such as older age (< 14) and higher grades that were associated with lower use of condoms. Additionally, other psychosocial factors such as suicidal ideation and attempts as well as physical violence, and lack of close friends decrease the odds of condom use. Substance use, particularly marijuana and amphetamine/methamphetamine, was also associated with lower condom use. Although all types of bullying experiences were associated with lower condom use in bivariate analyses, the association remained significant only for bullying at school in the adjusted model (AOR = 0.39, 95% CI: 0.18–0.86).

Conclusion
The findings emphasize a holistic approach to addressing bullying, particularly within schools, and promoting protected sexual behaviors among school-going adolescents through early anti-bullying interventions and incorporating tailored sex education into school curricula, and at Thai schools.
Place-based household vouchers for locally supplied fruit and vegetables: the Fresh Street pilot cluster randomised controlled trial
Authors: Relton C. , Blake M. K. , Bridge G. , Umney D. , Taylor S. J. C. , Adams J. , Mihaylova B. , Griffiths C. , Hooper R. , Phillips R. , Palmer L. , Gamston A. , Williamson K. 
Published: January 2025

Abstract
Background
Households in areas of socio-economic deprivation are more likely to consume diets low in fruit and vegetables. Fresh Street is a place-based fruit and vegetable voucher scheme with vouchers redeemable with local independent (non-supermarket) vendors. Paper vouchers are offered to all households in a geographical area regardless of household type, size, or income with no requirement to demonstrate need. The regular shareable vouchers are combined with recipes and dietary information to increase exposure to healthy food prompts, reduce food insecurity, increase fruit and vegetable consumption, improve dietary quality, and support healthy dietary habits.
This study aimed to inform a randomised controlled trial (RCT) to assess the impact of Fresh Street on a range of public health outcomes.

Methods
The pilot cluster RCT took place in three inner city areas of high socioeconomic deprivation in England (Tower Hamlets, Bradford, and Doncaster). New systems for managing vouchers and doorstep delivering weekly envelopes to households were developed. Weekly envelopes containing vouchers (5 x £1), a healthy seasonal recipe and brief nutritional information were offered to all households in nine intervention streets. Nine control streets received no intervention. Household surveys collected information on fruit and vegetable consumption, diet quality, and household characteristics.

Results
The household survey response rate was below the 50% target for progression to the main trial. Most local fruit and vegetable vendors accepted vouchers. Three quarters or more of households regularly accepted the envelopes. The scheme was well received by households, local vendors and local public health teams. Household uptake of the scheme was highest in Tower Hamlets (75%) and Bradford (83%). The mean weekly voucher redemption was highest in Tower Hamlets (£3.26) and Bradford (£2.82), where the scheme ran longest, and where vendors were nearby.

Conclusions
This was the first pilot RCT of a place-based, household voucher approach. The newly developed system for securely printing and redeeming the vouchers worked well and is potentially scalable.
Future trials should consider alternative methods of assessing the impact on households and explore more efficient ways to deliver the intervention e.g. through collaborative working with local resources such as community centres.