bluuebunny/crossref_metadata_2025_split huggingface dataset:
A High-resolution Colloidal Quantum Dot Imager by Monolithic Integration
Authors: Liu Jing , Liu Peilin , Chen Dengyang , Shi Tailong , Qu Xixi , Chen Long , Wu Tong , Ke Jiangping , Xiong Kao , Li Mingyu , Song Haisheng , Wei Wei , Cao Junkai , Zhang Jianbing , Gao Liang , Tang Jiang 
Published: July 2021

Abstract
Near-infrared (NIR, 0.7–1.4 µm) imagers have wide applications in night surveillance, material sorting, machine vision and potentially automatic driving. However, limited by the high-temperature processing and requirement of single-crystalline substrate, so far flip-chip is the dominant way to connect infrared photodiodes and silicon-based readout integrated circuit (ROIC) to produce infrared imagers, suffering from complicated process and ultra-high cost and hence limiting their widespread applications in the market. Here we report the monolithic integration of colloidal quantum dots (CQD) photodiodes with complementary metal-oxide-semiconductor (CMOS) ROIC, operating as a low-cost and high-performance imager. The CQD photodetector is well designed with a CMOS-compatible structure, demonstrating a response spectral range of 400–1300 nm, a detectivity of 2.1×1012 Jones at room temperature, a -3dB bandwidth of 140 kHz and a linear dynamic range over 100 dB. The CQD imager can identify materials, inspect apple scar and veins with a large size of 640×512 pixels and a spatial resolution of 40 lp/mm at a modulation transfer function of 50%. Monolithic integration significantly reduces the cost without sacrificing performance, thus providing huge potential for the ubiquitous deployment of infrared imagers.
Long-term follow-up of SARS-CoV-2 convalescents reveals
distinct magnitude of spike-specific immunity after viral re-exposure and vaccination
Authors: Knolle Percy , Körber Nina , Priller Alina , Yazici Sarah , Bauer Tanja , Cheng Cho-Chin , Mijocevic Hrvoje , Wintersteller Hannah , Jeske Samuel , Vogel Emanuel , Tinnefeld Kathrin , Gerhard Markus , Haller Bernhard , Christa Catharina , Zelger Otto , Roggendorf Hedwig , Halle Martin , Erber Johanna , Keppler Oliver , Zehn Dietmar , Protzer Ulrike , Lingor Paul 
Published: July 2021

Abstract
Infection with the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is controlled by the host´s immune response1-4, but longitudinal follow-up studies of virus-specific immunity to evaluate protection from re-infection are lacking. Here, we report the results from a prospective study that started during the first wave of the COVID-19 pandemic in spring 2020, where we identified 91 convalescents from mild SARS-CoV-2 infection among 4554 health care workers. We followed the dynamics and magnitude of spike-specific immunity in convalescents during the spontaneous course over ≥ 9 months, after SARS-CoV-2 re-exposure and after BNT162b2 mRNA vaccination. Virus-neutralizing antibodies and spike-specific T cell responses with predominance of IL-2-secreting polyfunctional CD4 T cells continuously declined over 9 months, but remained detectable at low levels. After a single vaccination, convalescents simultaneously mounted strong antibody and T cell responses against the SARS-CoV-2 spike proteins. In naïve individuals, a prime vaccination induced preferentially IL-2-secreting CD4 T cells that preceded production of spike-specific virus-neutralizing antibodies after boost vaccination. Response to vaccination, however, was not homogenous. Compared to four individuals among 455 naïve vaccinees (0.9%), we identified 5/82 (6.1%) convalescents with a delayed response to vaccination. These convalescents had originally developed dysfunctional spike-specific immune responses after SARS-CoV-2 infection, and required prime and boost vaccination to develop strong spike-specific immunity. Importantly, during the second wave of the COVID-19 pandemic in fall/winter of 2021 and prior to vaccination we detected a surge of virus-neutralizing antibodies consistent with re-exposure to SARS-CoV-2 in 6 out of 82 convalescents. The selective increase in virus-neutralizing antibodies occurred without systemic re-activation of spike-specific T cell immunity, whereas a single BNT162b2 mRNA vaccination sufficed to induce strong spike-specific antibody and systemic T cell responses in the same individuals. These results support the notion that BNT162b2 mRNA vaccination synchronizes spike-specific immunity in all convalescents of mild SARS-CoV-2 infection and may provide additional protection from re-infection by inducing more rigorous stimulation of spike-specific T cell immunity than re-exposure with SARS-CoV-2.
Tertiary lymphoid structures critical for prognosis in endometrial cancer patients - a TransPORTEC study
Authors: Horeweg Nanda , Workel Hagma , Loiero Dominik , Church David , Vermij Lisa , Léon-Castillo Alicia , Krog Ricki , de Boer Stephanie , Nout Remi , Powel Melanie , Mileshkin Linda , MacKay Helen , Leary Alexandra , Singh Naveena , Jürgenliemk-Schulz Ina , Creutzberg Carien , Koelzer Viktor , Nijman Hans , Bosse Tjalling , Bruyn Marco 
Published: July 2021

Abstract
B-cells play a key role in cancer suppression, particularly when aggregated in tertiary lymphoid structures (TLS). Here, we investigated the role of B-cells and TLS in endometrial cancer (EC). Single cell RNA-sequencing of B-cells showed presence of activated/memory B-cells, cycling/germinal center B-cells and antibody-secreting cells. Differential gene expression analysis showed association of TLS with L1CAM overexpression. Immunohistochemistry and co-immunofluorescence showed L1CAM expression in mature TLS localized in the myometrial wall or at the tumor invasive border, independent of L1CAM expression the tumor. Using L1CAM as a marker, 378 of the 411 molecularly classified ECs from the PORTEC-3 biobank were evaluated. TLS were found in 19%, predominantly in mismatch-repair deficient and polymerase-epsilon mutant EC. Multivariable Cox regression analysis showed strong favorable prognostic impact of TLS, independent of clinicopathological and molecular factors. Our data suggests a pivotal role of TLS in outcome of EC patients, and establishes L1CAM as a simple biomarker.Statement of significance Tertiary lymphoid structures have a pivotal role in the immune response against endometrial cancer. Presence of mature tertiary lymphoid structures can be easily assessed using L1CAM immunohistochemistry and has independent favorable predictive value for recurrence and endometrial cancer-specific survival.
Attenuation of Osteoarthritis Progression via a Combination of Intra-articular Injection of Synovial Membrane-derived MSCs (SMMSCs), Platelet Rich Plasma (PRP) and Conditioned Medium (Secretome)
Authors: Nabavizadeh Sara Sadat , Talaei-Khozani Tahereh , Zarei Moein , Zare Shahrokh , Hosseinabadi Omid Koohi , Tanideh Nader , Daneshi Sajad 
Published: July 2021

Abstract
Introduction: Osteoarthritis (OA) as a progressive destructive disease of articular cartilage is the most common joint disease characterized by reduction of joint cartilage thickness, demolition of cartilage surface and new bone formation. To overcome these problems, the purpose of the current research was to evaluate and compare the in vivo effects of Synovial membrane-derived MSCs (SMMSCs), platelet rich plasma (PRP) and conditioned medium (secretome) on collagenase II-induced rat knee osteoarthritis (KOA) remedy. Methods: For the first step, SMMSCs were isolated and characterized. Also, secretome was collected from SMMSCs culture. Furthermore, PRP was collect from the rat heart venous blood. Second, two injection of collagenase II with an interval of 3 days was performed in the knee intra- articular space to induce osteoarthritis. Two weeks later, animals were randomly divided into 6 groups. Control group without treatment, positive group: taken an intra-articular Hyalgan injection (0.1 cc), treatment groups taken an intra-articular injection of; treatment 1: SMMSCs (5 × 106), treatment 2: SMMSCs (5 × 106) + secretome (50 µl), treatment 3: SMMSCs (5 × 106) + PRP (50 µl), and treatment 4: SMMSCs (5 × 106) + secretome (50 µl) + PRP (50 µl). Three months later, rats were sacrificed and the following assessments were executed: radiography, histopathology, and immunohistochemistry. Results: Our findings represented that a combination of the SMMSCs with PRP and secretome had a considerable effect on GAGs and collagen II contents, articular cartilage preservation, compared with other groups. In addition, combination of the SMMSCs with PRP and secretome showed the lowest expression of mmp3, while SOX9 had the highest expression in comparision with other groups. Also, SMMSCs -injected groups demonstrated better results compared with positive and control groups. Conclusions: Injection a combination of the SMMSCs with PRP and secretome resulted in better efficacy in terms of joint space width, articular cartilage surface continuity and integrity, sub chondral bone and ECM constituents such as collagen II. Indeed, transplantation of this combination could be considered as a promising therapy for patients with KOA.
On the Classification of Modulation Schemes using Higher Order Statistics and Support Vector Machines
Authors: C Remziye Büsra , Yalcinkaya Bengisu , Benzaghta Mohamed , Kara Ali 
Published: July 2021

Abstract
The recognition of modulation schemes in military and civilian applications is a major task for intelligent receiving systems. Having no previous knowledge of the transmitted signal as well as uncertainties in the channel and the receiver makes the identification of the modulation scheme a difficult task. Various Automatic Modulation Classification (AMC) algorithms have been developed to overcome this challenging task. However, classification with low computational complexity as well as reasonable processing time is still a challenge, especially, for modulation types with similar constellations under realistic channel conditions. In this paper, a feature-based approach along with various classifiers is employed based on statistical features as well as higher-order moments and cumulants. First, some well-known classifiers including Decision Trees (DT), Support Vector Machines (SVM), K-Nearest Neighbors (KNN) and ensemble are evaluated at different SNR values. Then, various forms of SVMs have been utilized. An over-the-air (OTA) recorded dataset consisting of four analog and ten digital modulation schemes are used for testing the proposed method. The classification performance is compared against SNR (0-20 dB). The overall accuracy for quadratic SVM is found to be as high as 98% at 10 dB. This has been comparable with the reported performance based on simulated dataset. Overall, the comparison of the results with those published in the literature indicates that this is the first paper presenting such a high accuracy with OTA dataset consisting of fourteen modulation schemes.
Microbial Structure and Diversity in Rhizosphere Soil under Different Forest Types in the Subtropical Zone of China
Authors: Zhou Liuting , Li Jianjuan , Zhang Chen , Guo Xinlai , Chu Wei , Zhao Yanlin , Wu Chengzhen , Lin Wenxiong , Wu Zeyan 
Published: July 2021

Abstract
The aim of this study was to explore the soil microbial variability within different forest ecosystems (evergreen broad-leaf forest (EBF), coniferous forest (CF), subalpine dwarf forest (SDF) and alpine meadow (AM) at different altitudes in mid-subtropics of China. The phospholipid fatty acid (PLFA) method was used to analyze the microbial communities in rhizosphere soil under different forest types. The relationships were also analyzed between the microbial diversity and soil nutrients. A total of 27 PLFA biomarkers were detected and the PLFA concentrations decreased in the sequence of bacteria > fungus > actinomycete > protozoa in all forest types. The microbial communities in the soil under all forest types were distinct. The predominant microflora in all soils were 18:1ω9c, 16:1ω7c, cy19:0, a17:0 and 18:0. The indexes of Simpson, Shannon-Wiener and Brillouin of soil microbial community diversity in these four forest types all showed a trend of EBF > CF > SDF > AM. According to principal component analyses (PCA), the variable variances of principal components 1 and 2, which were related to the PLFA biomarkers of soil microorganisms, were 67.67% and 17.91%, respectively. Furthermore, the total PLFAs of different soil microbial groups showed a correlation with soil nutrients and enzyme activities in all forest types. The soil microbial diversity gradually decreased in the order of EBF > CF > SDF > AM in the Daiyun Mountains. Different vegetation types affect soil microbial community composition and diversity by changing the soil physicochemical properties and enzyme activity.
Overview of Nurse Anxiety Screening Dealing with the Covid-19 Pandemic
Authors: Tohri Tonika , Yuliani Risna , Ramadhan Muhammad Deri 
Published: July 2021

Abstract
BackgroundThe increasing number of Covid-19 patients every day has caused anxiety in all circles of society, including nurses. Even though these prevention efforts have been carried out strictly, the potential for exposure to this virus is still quite high, even causing clusters in several buildings at Hasan Sadikin Hospital (RSHS) Indonesia. DestinationKnowing An overview of nurses' anxiety screening in the face of the Covid-19 pandemic and an overview nurse characteristics at RSHS by gender, age, education level. MethodologyThe research design is descriptive. The number of research samples is 301 people. The sampling technique is Probability Sampling: Cluster Random Sampling. The research time is March 2021 using the Coronavirus Anxiety Scale (CAS). ResultOf the total respondents 301 people there are 14 (4.65) people experiencing dysfunctional anxiety, women i.e. 13 (4.32) people, aged 26 - < 46 years old that is 9 (2.99) people and D3 is 8 (2.66) people. ConclusionThe picture of nurses' anxiety at RSHS is very low because the pandemic has been running for 1 (one) year, the researcher recommends doing research by comparing the anxiety of nurses at the beginning of the pandemic with the current pandemic.
Anlotinib induces tumor blood vessel normalization to strengthen the anticancer effect of radiotherapy on esophageal cancer by inhibiting EphA2
Authors: Zhu Weiguo , Huang Jing , Gu Zhenlin , Huang Jiasheng , Xu Yingying , Wang Wanwei 
Published: July 2021

Abstract
Background

Anlotinib has anti-tumor activity in diverse solid tumors. Given that, our study was designed to unearth the mechanism of Anlotinib in radioresistant esophageal cancer (EC) cells by modulating Ephrin type-A receptor 2 (EphA2).
Methods

EC cells (TE-1 and KYSE-150) were induced to radioresistant EC cells (TE-1R and KYSE-150R). EphA2 expression in TE-1R and KYSE-150R cells was measured. Then, TE-1R and KYSE-150R cells were treated with Anlotinib and/or transfected with the plasmids that altered EphA2 expression. Otherwise, TE-1R and KYSE-150R cells were transfected with si-EphA2 or OE-EphA2 plasmids independently. In vitro experiments were conducted to monitor cell proliferation, angiogenesis, migration and invasion. In vivo experiment was also implemented to observe tumor growth.
Results

EphA2 expression was raised in TE-1R and KYSE-150R cells. Anlotinib inhibited proliferation, angiogenesis, migration and invasion of TE-1R and KYSE-150R cells in vitro, as well as tumor growth and MVD in vivo. Inhibiting EphA2 enhanced Anlotinib-mediated effects on TE-1R and KYSE-150R cells. Down-regulating EphA2 restrained proliferation, angiogenesis, migration and invasion of TE-1R and KYSE-150R cells.
Conclusion

It is concluded that Anlotinib suppresses EC development under radiotherapy by inhibiting EphA2, providing another perspective to overcome radioresistance in EC.
Single-Atom Tungsten Doped Nis0.5Se0.5 Nanosheets@Nanorods Heterostructures Catalyze Water Splitting Highly Active and Durable
Authors: Wang Yang , Li Xiaopeng , Zhang Mengmeng , Zhang Jinfeng , Chen Zelin , Zheng Xuerong , Zhao Naiqin , Tian Zhangliu , Han Xiaopeng , Zaghib Karim , Wang Yuesheng , Deng Yida , Hu wenbin 
Published: July 2021

Abstract
Developing robust nonprecious electrocatalysts towards hydrogen/oxygen evolution reaction (HER/OER) is crucial for the spread of hydrogen energy industrialization. Here, we prepared a highly active and durable electrocatalyst of W single-atoms doped NiS0.5Se0.5 nanosheets@NiS0.5Se0.5 nanorods heterostructure (W-NiS0.5Se0.5). The W-NiS0.5Se0.5 exhibits superior catalytic activity for HER and OER with an ultralow overpotential (39, 106 mV for HER and 171, 239 mV for OER) and excellent long-term durability (500 h) at 10 and 100 mA cm− 2, outperforming commercial precious-metal catalysts and many other reported transition-metal-based compounds. The spin state of Ni was delocalized by introducing low spin-state of W single-atom, thus increasing the electron density of Ni 2p orbital, optimizing the adsorption/desorption process of H, significantly reducing the energy barrier of the rate-determining step (O* → OOH*), finally accelerating thermodynamics and kinetics of HER/OER. This work provides a rational feasible strategy to design single-atom catalysts for water splitting and develop advanced transition metal-based electrocatalysts via regulating delocalized spin states.
Synchronous Organ Failure and Infected Pancreatic Necrosis Define Genuine Critical Acute Pancreatitis
Authors: Shen Dingcheng , Wei Qin , Huang Haosu , Ning Caihong , Li Jiarong , Chen Lu , Zhu Shuai , Huang Gengwen 
Published: July 2021

Abstract
Background: The determinant-based classification (DBC) of acute pancreatitis (AP) was proposed in 2012. One of the highlights of the DBC was critical acute pancreatitis (CAP), which was supposed to be strongly associated with the highest risk of adverse outcomes. However, the definition of CAP needs to be further clarified.Methods: A prospective cohort with consecutive patients of infected pancreatic necrosis (IPN) at a tertiary hospital was analyzed. Patients were assigned to IPN alone, Metachronous-CAP (MCAP) and Synchronous-CAP group (SCAP) according to presence or absence of organ failure (OF) and the crosstalk between OF and IPN. Clinical interventions and outcomes were compared among groups.Results: A total of 248 IPN patients were enrolled and the overall mortality was 25.8%. Compared with MCAP, patients with SCAP were associated with higher mortality (45/68, 66.2% vs. 5/50, 10.0%; OR= 17.6,95% CI, 6.2-50.4; P < 0.001) and morbidity (28/68, 41.2% vs. 9/50, 18.0%; P = 0.013), longer duration of OF (median 35.5 days vs. 12.0 days, P < 0.001), longer ICU length of stay (LOS) (median 28.0 days vs. 16.0 days, P = 0.001), longer hospital LOS (median 67.0 days vs. 60.0 days, P < 0.001) as well as earlier requirement for surgical interventions. The IPN alone and MCAP had comparable mortality (10.8% vs. 10.0%, P = 0.88), morbidity and hospital LOS, except that MCAP patients were characterized with longer duration of OF and ICU LOS (P< 0.05).Conclusions: SCAP, characterized with synchronous persistent OF and IPN, was associated with higher mortality and morbidity and should be defined as genuine CAP.
WITHDRAWN: Reliability Framework for Characterizing Heat Wave and Cold Spell Events
Authors: Moghim Sanaz , Jahangir Mohammad Sina 
Published: July 2021

Abstract
Extreme weather events such as heat waves and cold spells affect people’s lives. This study uses a probabilistic framework to evaluate heat waves and cold spells in different regions (Tehran in Iran and Vancouver in Canada). Average daily temperatures of meteorological stations of the two cities from 1995 to 2016 are used to identify four main indicators including intensity, average intensity, duration, and the rate of the occurrence. In addition, average intensities of the events are obtained from the MODIS Land Surface Temperature (LST) in each pixel of the two cities. To include possible uncertainties, the predictive probability distributions of the intensity and duration are derived using a Bayesian scheme and Monte-Carlo Markov Chain (MCMC) method. The probability distributions of the indicators show that the most extreme temperature (lowest temperature) occurs during the cold spell. Results indicate that although Tehran is more probable to experience heat waves than Vancouver, both cities are more likely to be affected by the cold spell than the heat wave. The developed approach can be used to characterize other extreme weather events in any location.
Recognition of Inter-Class Variation of Human Actions in Sports Video
Authors: Akila.K  
Published: July 2021

Abstract
Background: Human action recognition encompasses a scope for an automatic analysis of current events from video and has varied applications in multi-various fields. Recognizing and understanding of human actions from videos still remains a difficult downside as a result of the massive variations in human look, posture and body size inside identical category.Objective: This paper focuses on a specific issue related to inter-class variation in Human Action Recognition.Approach: To discriminate the human actions among the category, a novel approach which is based on wavelet packet transformation for feature extraction. As we are concentrating on classifying similar actions non-linearity among the features are analyzed and discriminated by Deterministic Normalized - Linear Discriminant Analysis (DN-LDA). However the major part of the recognition system relays on classification part and the dynamic feeds are classified by Hidden Markov Model at the final stage based on rule set..Conclusion: Experiments results have shown that the proposed approach is discriminative for similar human action recognition and well adapted to the inter-class variation
The Effect of Guilu Erxian Jiao on Osteoporosis Patients: A Retrospective Study
Authors: Lai Yuan-Xin , Tseng Chu-Yao , Yang Huang-Yu , Yang Sien-Hung , Yang Tsung-Hsien 
Published: July 2021

Abstract
Background: This retrospective study aimed to evaluate whether the Chinese herbal medicine formula Guilu Erxian Jiao can improve T-score in osteoporosis patients diagnosed by dual energy x-ray absorptiometry (DXA) and even decrease fracture rate.Method: Osteoporosis participants were collected through the Chang Gung Memorial Hospital (CGMH) database from 2000 to 2019. Intervention was taking Guilu Erxian Jiao pills. We analyzed the change of T-score and the following cumulative incidence of fracture. The Student’s T-test, Cox’s proportional hazard model, Kaplan-Meier method and log-rank test were conducted using SAS software.Results: There was no significant difference about the baseline between the Guilu Erxian Jiao group and non-Guilu Erxian Jiao group. Guilu Erxian Jiao can improve the osteoporosis of the vertebrate of lumbar. However, there is no significant diffidence about the vertebrate of lumbar and femoral neck between the Guilu Erxian Jiao group and non-Guilu Erxian Jiao group. The cumulative rate of fracture between these two groups is no significant difference. However, if patients took the total dose of Guilu Erxian Jiao over 600 pill*days, the fracture rate would decrease.Conclusion: Usage of Guilu Erxian Jiao would improve the osteoporosis of vertebrate of lumbar, but does not improve the cumulative incidence of fracture, unless they took the total dose of Guilu Erxian Jiao over 600 pill*days.