bluuebunny/crossref_metadata_2025_split huggingface dataset:
West Nile virus in crocodiles and mosquitoes in Zimbabwe
Authors: Roy Marlène , Mufunda Fortunate , Slawski Deirdre , Mutswiri Charmaine , Mvere Irene , Slawski Katherine , Kelly Pamela , Piras Ilaria , Bezuidenhout Annemarie , Hanyire Tapiwanashe , Markey Bryan , Barry Gerald 
Published: February 2021

AbstractWe detected, for the first time, West Nile virus lineages 1 and 2 in Zimbabwe in mosquitoes and crocodile tissue samples, including fluid from egg waste. Our results provide evidence of WNV circulation in Zimbabwe, suggesting that an evaluation of the risk to humans and susceptible animals should be considered.
Rapid neural categorization of facelike objects predicts the perceptual awareness of a face (face pareidolia)
Authors: Rekow Diane , Baudouin Jean-Yves , Brochard Renaud , Rossion Bruno , Leleu Arnaud 
Published: February 2021

AbstractThe human brain rapidly and automatically categorizes facesvs. other visual objects. However, whether face-selective neural activity predicts the subjective experience of a face –perceptual awareness– is debated. To clarify this issue, here we useface pareidolia, i.e., the illusory perception of a face, as a proxy to relate the neural categorization of a variety of facelike objects to conscious face perception. In Experiment 1, scalp electroencephalogram (EEG) is recorded while pictures of human faces or facelike objects – in different stimulation sequences – are interleaved every second (i.e., at 1 Hz) in a rapid 6-Hz train of natural images of nonface objects. Participants do not perform any explicit face categorization task during stimulation, and report whether they perceived illusory faces post-stimulation. A robust categorization response to facelike objects is identified at 1 Hz and harmonics in the EEG frequency spectrum with a facelike occipito-temporal topography. Across all individuals, the facelike categorization response is of about 20% of the response to human faces, but more strongly right-lateralized. Critically, its amplitude is much larger in participants who report having perceived illusory faces. In Experiment 2, facelike or matched nonface objects from the same categories appear at 1 Hz in sequences of nonface objects presented at variable stimulation rates (60 Hz to 12 Hz) and participants explicitly report after each sequence whether they perceived illusory faces. The facelike categorization response already emerges at the shortest stimulus duration (i.e., 17 ms at 60 Hz) and predicts the behavioral report of conscious perception. Strikingly, neural facelike-selectivity emerges exclusively when participants report illusory faces. Collectively, these experiments characterize a neural signature of face pareidolia in the context of rapid categorization, supporting the view that face-selective brain activity reliably predicts the subjective experience of a face from a single glance at a variety of stimuli.Highlights- EEG frequency-tagging measures the rapid categorization of facelike objects- Facelike objects elicit a facelike neural categorization response- Neural face categorization predicts conscious face perception across variable inputs
Comparison of toll and annuity PPPs: a case study of highway projects in India
Authors: Mangu Samhita , Annamalai Thillai Rajan , Deep Akash 
Published: February 2021

PurposeThe use of public–private partnership (PPP) approaches for developing infrastructure has been well recognized. The allocation of risk between public authority and private sector differs among the different types of PPP projects. The objective of the paper is to analyze the factors that influence the type of PPP and the performance of different types of PPP contracts.Design/methodology/approachA unique data set of 202 national highway PPP projects from India, comprising 154 toll and 48 annuity projects formed the basis of the study.FindingsThere are significant differences between toll and annuity PPP projects. The former are longer, are implemented in better developed states but are also characterized by higher cost over-runs. The latter are characterized by higher debt–equity ratio.Practical implicationsMitigating revenue risk can significantly enhance the debt capacity of the projects, thereby reducing the overall cost of capital. To make toll roads attractive for bidders, they have to be developed as longer stretches. Toll projects that are immediately ready for development at the time of award would reduce cost overruns of toll projects and sustain the interest of private developers.Originality/valueComparison of toll and annuity PPP road projects has never been done previously. The unique data set used in this study highlights the differences in characterization and performance for both the project types. The study provides evidence support to “intuition” and enables policymakers to choose the right form of PPP to realize their objectives.
Prediction of SLS parts properties using reprocessing powder
Authors: Lopes Ana C. , Sampaio Álvaro M. , Silva Cátia S. , Pontes António J. 
Published: February 2021

Purpose
Owing to the operating principle of powder bed fusion processes, selective laser sintering (SLS) requires effective management of the mixture ratio of processed material previously exposed to the high temperatures of processing with new virgin material. Therefore, this paper aims to fully understand the effect that the successive reprocessing has in the powder material and to evaluate its influence on the properties of SLS parts produced at different building orientations.

Design/methodology/approach
Polyamide 12 material with 0%, 30% and 50% of virgin powder and parts produced from them were studied through five consecutive building cycles and their mass, mechanical, thermal and microstructural properties were evaluated. Then, the experimental data was used to validate a theoretical algorithm of prediction capable to define the minimum amount of virgin powder to be added on the processed material to produce parts without significant loss of properties.

Findings
Material degradation during SLS influences the mass and mechanical properties of the parts, exhibiting an exponential decay property loss until 50% of the initial values. The theoretical algorithms of reprocessing proved the appropriateness to use a mixture of 30% of virgin with 70% of processed material for the most common purposes.

Practical implications
This paper validates a methodology to define the minimum amount of virgin material capable to fulfil the operational specifications of SLS parts as a function of the number of building cycles, depending on the requirements of the final application.

Originality/value
The use of theoretical models of prediction allows to describe the degradation effects of SLS materials during the sintering, ensuring the sustainable management of the processed powder and the economic viability of the process.
Commentary on “What are the experiences of professionals working with parents with learning disabilities? A meta-ethnography”
Authors: MacIntyre Gillian , Stewart Ailsa 
Published: February 2021

Purpose
The purpose of this paper is to provide a commentary on Pytlowana and Stenfert Kroese’s article on the experiences of professionals working with parents with learning disabilities by exploring challenges and good practice in this area.

Design/methodology/approach
Key areas of practice were identified for further exploration by drawing on research studies with parents with learning disabilities.

Findings
While there is growing evidence of good practice around working with parents with learning disabilities, a number of challenges around communication and relationship-based practice remain. The paper recommends further training and education for those working in this complex area of practice.

Originality/value
The paper adds value by bringing together evidence from across a number of studies to highlight good practice.
Early head‐to‐pelvis computed tomography in out‐of‐hospital circulatory arrest without obvious etiology
Authors: Branch Kelley R. H. , Strote Jared , Gunn Martin , Maynard Charles , Kudenchuk Peter J. , Brusen Robin , Petek Bradley J. , Sayre Michael R. , Edwards Rachael , Carlbom David , Counts Catherine R. , Probstfield Jeffrey L. , Gatewood Medley O. 
Published: February 2021

AbstractObjectivesPatients resuscitated from an out‐of‐hospital circulatory arrest (OHCA) commonly present without an obvious etiology. We assessed the diagnostic capability and safety of early head‐to‐pelvis computed tomography (CT) imaging in such patients.MethodsFrom November 2015 to February 2018, we enrolled 104 patients resuscitated from OHCA without obvious cause (idiopathic OHCA) to an early sudden‐death CT (SDCT) scan protocol within 6 h of hospital arrival. The SDCT protocol included a noncontrast CT head, an electrocardiogram‐gated cardiac and thoracic CT angiogram, and a nongated venous‐phase abdominopelvic CT angiogram. Patients needing urgent cardiac catheterization or hemodynamically unable to tolerate SDCT were excluded. Cardiac CT analyses were blinded, but other SDCT findings were clinically available. Primary endpoints were the number of OHCA causes identified by SDCT compared to the adjudicated cause and critical diagnoses identified by SDCT, including resuscitation complications. Safety endpoints were acute kidney injury (AKI) and inappropriate treatments based on SDCT findings. Acute coronary syndrome was the presumed etiology if any major coronary artery had a >50% stenosis without another OHCA cause.ResultsSDCT scans occurred within 1.9 ± 1.0 h of hospital arrival and identified 39% (41/104) of all OHCA causes and 95% (39/41) of causes potentially identifiable by SDCT. Critical findings were identified by SDCT in 98% (43/44) of patients that included potentially life‐threatening resuscitation complications of liver or spleen laceration (n = 6); pneumothorax or thoracic organ laceration (n = 8); and mediastinal, pericardial, or vascular hemorrhage (n = 3). SDCT exclusively identified 13 (13%) OHCA causes that would otherwise not be identified without SDCT imaging. No inappropriate treatments resulted from SDCT findings. AKI was common (28%) but only one (1%) patient required new dialysis.ConclusionsThis observational cohort study suggests that early SDCT scanning is safe, can expedite the diagnosis of potential causes, and can meaningfully change clinical management after idiopathic OHCA.
Boundary management and accounting visibility in social services: a case study
Authors: Alam Manzurul , Hoque Zahirul 
Published: February 2021

AbstractThis paper examines how accounting systems are disseminated in different ways as organisations seek to use accounting information to manage social services across organisational boundaries. Drawing upon qualitative field research within a New Zealand community‐care provider and using the literature on bounded management and accounting visibility, our findings reveal that the government's increasing screening and monitoring of social support services create an extra burden on carers and families. We reflect on how internal accounting practices only capture the visible costs endured by government‐funded programmes, ignoring a significant part of disability care costs incurred by family members and other carers.
A case of lymphangioma circumscriptum with new reflectance confocal microscopy findings
Authors: Karaarslan Isil , Oraloglu Gokturk , Yaman Banu 
Published: February 2021

AbstractIn vivo reflectance confocal microscopy (RCM) findings of lymphangiomas have been scarcely reported. We report a lymphangioma circumscriptum (LC) with some new observations.
Short‐term repeatability of the peguero‐lo presti electrocardiographic left ventricular hypertrophy criteria
Authors: Drager Dominique , Soliman Elsayed Z. , Meyer Michelle L. , Zhang Zhu‐Ming , Alonso Alvaro , Heiss Gerardo , Whitsel Eric A. 
Published: February 2021

AbstractBackgroundElectrocardiographic left ventricular hypertrophy (ECG‐LVH) represents preclinical cardiovascular disease and predicts cardiovascular disease morbidity and mortality. While the newly developed Peguero‐Lo Presti ECG‐LVH criteria have greater sensitivity for LVH than the Cornell voltage and Sokolow–Lyon criteria, its short‐term repeatability is unknown. Therefore, we characterized the short‐term repeatability of Peguero‐Lo Presti ECG‐LVH criteria and evaluate its agreement with Cornell voltage and Sokolow–Lyon ECG‐LVH criteria.MethodsParticipants underwent two resting, standard, 12‐lead ECGs at each of two visits one week apart (n = 63). We defined a Peguero‐Lo Presti index as a sum of the deepest S wave amplitude in any single lead and lead V4 (i.e., SD + SV4) and defined Peguero‐Lo Presti LVH index as ≥ 2,300 µV among women and ≥ 2,800 µV among men. We estimated repeatability as an intraclass correlation coefficient (ICC), agreement as a prevalence‐adjusted bias‐adjusted kappa coefficient (κ), and precision using 95% confidence intervals (CIs).ResultsThe Peguero‐Lo Presti index was repeatable: ICC (95% CI) = 0.94 (0.91–0.97). Within‐visit agreement of Peguero‐Lo Presti LVH was high at the first and second visits: κ (95% CI) = 0.97 (0.91–1.00) and 1.00 (1.00–1.00). Between‐visit agreement of the first and second measurements at each visit was comparable: κ (95% CI) = 0.90 (0.80–1.00) and 0.93 (0.85–1.00). Agreement of Peguero‐Lo Presti and Cornell or Sokolow–Lyon LVH on any one of the four ECGs was slightly lower: κ (95% CI) = 0.71 (0.54–0.89).ConclusionThe Peguero‐Lo Presti index and LVH have excellent repeatability and agreement, which support their use in clinical and epidemiological studies.
Predicting distant metastatic disease in differentiated thyroid cancer: a matchedcase–controlstudy
Authors: Jaffar Sukaina , Jayasekara Jayani , Aniss Ahmad M. , Tsang Venessa H. M. , Learoyd Diana L. , Clifton‐Bligh Roderick , Gill Anthony J. , Glover Anothony R. , Sidhu Stan B. , Robinson Bruce , Sywak Mark 
Published: February 2021

AbstractBackgroundThe occurrence of distant metastasis (DM) is the most important prognostic factor influencing survival outcomes in differentiated thyroid cancer (DTC). Identifying patients who are likely to develop DM and offering these cases more aggressive surgical approaches and I‐131 therapy, is paramount to achieving the best possible outcomes. DM on presentation in DTC are uncommon, with an incidence of 1–9%. However, the incidence of DTC is rising and the disease affects a relatively young cohort of patients. The aims of this study were to investigate predictive factors in the development of DM by comparing a homogenous group of DTC patients with and without DM, and to illustrate the overall and disease‐specific survival (DSS) rates of DTC patients presenting with DM.MethodsA matched case–control study of patients with DTC and DM was undertaken. The study group comprised a consecutive series of cases with DM treated in the period 1968–2014. Patients with DM at initial presentation were identified (DTC‐DM group). A control group of patients without DM were matched based on age, gender, tumour size and histological subtype. The primary outcome measures were overall and disease‐free survival. Secondary outcome measures were lymph node involvement (LNI), extra‐thyroidal extension (ETE) of tumour and presence of BRAFV600E mutation identified on immunohistochemistry.ResultsA total of 2547 patients with DTC were reviewed and of these 83 (3.26%) had DM at initial presentation. At 5 and 10 years, the overall survival rates for DTC‐DM patients were 89.6% and 64%, respectively. The 5 and 10 year DSS rates for DTC‐DM cases were 90.2% and 67.3%, respectively. When compared to the DTC group, the DTC‐DM group had significantly higher rates of ETE (63% vs. 29.5%,P< 0.0001) and LNI (32.5% vs. 18.8%,P= 0.044). Among patients with papillary thyroid cancer (PTC), the presence of BRAFV600E mutation was significantly associated with DM (62.2% vs. 36.8%,P= 0.028).ConclusionETE, LNI and BRAFV600E mutation in PTC are significant predictors for the development of distant metastatic disease.
Dexamethasone use and mortality in hospitalized patients with coronavirus disease 2019: A multicentre retrospective observational study
Authors: Hoertel Nicolas , Sánchez‐Rico Marina , Vernet Raphaël , Beeker Nathanaël , Neuraz Antoine , Alvarado Jesús M. , Daniel Christel , Paris Nicolas , Gramfort Alexandre , Lemaitre Guillaume , Salamanca Elisa , Bernaux Mélodie , Bellamine Ali , Burgun Anita , Limosin Frédéric ,   AP‐HP/Université de Paris/INSERM Covid‐19 research collaboration and AP‐HP Covid CDR Initiative
Published: February 2021

AimsTo examine the association between dexamethasone use and mortality among patients hospitalized for COVID‐19.MethodsWe examined the association between dexamethasone use and mortality at AP‐HP Greater Paris University hospitals. Study baseline was defined as the date of hospital admission. The primary endpoint was time to death. We compared this endpoint between patients who received dexamethasone and those who did not in time‐to‐event analyses adjusted for patient characteristics (such as age, sex and comorbidity) and clinical and biological markers of clinical severity of COVID‐19, and stratified by the need for respiratory support, i.e. mechanical ventilation or oxygen. The primary analysis was a multivariable Cox regression model.ResultsOf 12 217 adult patients hospitalized with a positive COVID‐19 reverse transcriptase–polymerase chain reaction test, 171 (1.4%) received dexamethasone orally or by intravenous perfusion during the visit. Among patients who required respiratory support, the end‐point occurred in 10/63 (15.9%) patients who received dexamethasone and 298/1129 (26.4%) patients who did not. In this group, there was a significant association between dexamethasone use and reduced mortality in the primary analysis (hazard ratio, 0.46; 95% confidence interval 0.22–0.96, P = .039). Among patients who did not require respiratory support, there was no significant association between dexamethasone use and the endpoint.ConclusionsIn this multicentre observational study, dexamethasone use administered either orally or by intravenous injection at a cumulative dose between 60 mg and 150 mg was associated with reduced mortality among patients with COVID‐19 requiring respiratory support.
Radioimmunotherapy with an 211At‐labeled anti–tissue factor antibody protected by sodium ascorbate
Authors: Takashima Hiroki , Koga Yoshikatsu , Manabe Shino , Ohnuki Kazunobu , Tsumura Ryo , Anzai Takahiro , Iwata Nozomi , Wang Yang , Yokokita Takuya , Komori Yukiko , Mori Daiki , Usuda Sachiko , Haba Hiromitsu , Fujii Hirofumi , Matsumura Yasuhiro , Yasunaga Masahiro 
Published: February 2021

AbstractTissue factor (TF), the trigger protein of the extrinsic blood coagulation cascade, is abundantly expressed in various cancers including gastric cancer. Anti‐TF monoclonal antibodies (mAbs) capable of targeting cancers have been successfully applied to armed antibodies such as antibody‐drug conjugates (ADCs) and molecular imaging probes. We prepared an anti‐TF mAb, clone 1084, labeled with astatine‐211 (211At), as a promising alpha emitter for cancer treatment. Alpha particles are characterized by high linear energy transfer and a range of 50‐100 µm in tissue. Therefore, selective and efficient tumor accumulation of alpha emitters results in potent antitumor activities against cancer cells with minor effects on normal cells adjacent to the tumor. Although the 211At‐conjugated clone 1084 (211At‐anti‐TF mAb) was disrupted by an 211At‐induced radiochemical reaction, we demonstrated that astatinated anti‐TF mAbs eluted in 0.6% or 1.2% sodium ascorbate (SA) solution were protected from antibody denaturation, which contributed to the maintenance of cellular binding activities and cytocidal effects of this immunoconjugate. Although body weight loss was observed in mice administered a 1.2% SA solution, the loss was transient and the radioprotectant seemed to be tolerable in vivo. In a high TF–expressing gastric cancer xenograft model, 211At‐anti‐TF mAb in 1.2% SA exerted a significantly greater antitumor effect than nonprotected 211At‐anti‐TF mAb. Moreover, the antitumor activities of the protected immunoconjugate in gastric cancer xenograft models were dependent on the level of TF in cancer cells. These findings suggest the clinical availability of the radioprotectant and applicability of clone 1084 to 211At‐radioimmunotherapy.
Multipanel assay of 17 tumor‐associated antibodies for serological detection of stage 0/I breast cancer
Authors: Sumazaki Makoto , Ogata Hideaki , Nabeya Yoshihiro , Kuwajima Akiko , Hiwasa Takaki , Shimada Hideaki 
Published: February 2021

AbstractBecause the production of tumor‐associated antibodies (TAA) is a humoral immune response in cancer patients, serum autoantibodies may be detected even in patients with early‐stage tumors. Seventeen recombinant proteins with tags in Escherichia coli (p53, RalA, p90, NY‐ESO‐1, HSP70, c‐myc, galectin‐1, Sui1, KN‐HN‐1, HSP40, PrxVI, p62, cyclin B1, HCC‐22‐5, annexin II, HCA25a, and HER2) were applied as capturing antigens in sandwich ELISA to measure serum IgG levels. Sera from 73 healthy donors and 386 patients with breast cancer, including 182 stage 0/I patients, were evaluated using cutoff values for each TAA equal to the mean +3 SD of the serum levels of healthy controls. The positive TAA rates were relatively high for p53 (10%) and RalA (10%). The positive rates of all TAA of stage 0/I were similar to those of all patients. Even in the stage 0/I patients, 24% showed that two or more TAA were positive, and the positive rate of a five‐TAA combination assay was 37%. The positivity rate was significantly higher for the non–luminal type than for the luminal type (P = .003). Logistic analysis showed that seropositivity (positive for one or more TAA) in breast cancer patients was independent from any TNM factor or disease stage and was significantly associated with histological grade in the multivariate analysis (P = .007). TAA in breast cancer patients may be useful for early detection. However, seropositivity of breast cancer reflects the tumor characteristics but not the disease stage.
Single‐center utilization of donor‐derived cell‐free DNA testing in the management of heart transplant patients
Authors: Gondi Keerthi T. , Kao Andrew , Linard Jodie , Austin Bethany A. , Everley Mark P. , Fendler Timothy J. , Khumri Taiyeb , Lawhorn Stephanie L. , Magalski Anthony , Nassif Michael E. , Sperry Brett W. , Vodnala Deepthi , Borkon A. Michael 
Published: February 2021

AbstractBackgroundGene expression profiling (GEP) and donor‐derived cell‐free DNA (dd‐cfDNA) are useful in acute rejection (AR) surveillance in orthotopic heart transplant (OHT) patients. We report a single‐center experience of combined GEP and dd‐cfDNA testing for AR surveillance.MethodsGEP and dd‐cfDNA are tested together starting at 2 months post‐OHT. After 6 months, combined testing was obtained before scheduled endomyocardial biopsy (EMB), and EMB was canceled with a negative dd‐cfDNA. This approach was compared to using a GEP‐only approach, where EMB was canceled with a negative GEP. We evaluated for frequency of EMB cancellation with dd‐cfDNA usage.ResultsA total of 153 OHT patients over a 13‐month period underwent 495 combined GEP/dd‐cfDNA tests. 82.2% of dd‐cfDNA tests were below threshold. Above threshold results identified high‐risk patients who developed AR. 378 combined tests ≥6 months post‐OHT resulted in cancellation of 83.9% EMBs as opposed to 71.2% with GEP surveillance alone. There were 2 acute cellular and 2 antibody‐mediated rejection episodes, and no significant AR ≥6 months.ConclusionRoutine dd‐cfDNA testing alongside GEP testing yielded a significant reduction in EMB volume by re‐classifying GEP (+) patients into a lower risk group, without reduction in AR detection. The addition of dd‐cfDNA identified patients at higher risk for AR.