bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role model nursing leaders in COVID-19 crisis
Authors: Mollahadi Mohsen , Mokhtari Nouri Jamileh , Moradian Seyed Tayeb 
Published: October 2021

BackgroundApplying the principles and skills of management, including planning, organising and leadership skills, will greatly help to improve the quality of nursing manager duties. This is even more important during crisis management, such as the COVID-19 crisis. The objective of the present study was to express the experiences of nursing managers in the COVID-19 crisis.MethodsA qualitative conventional content analysis approach was used to discover the nursing leadership style in the COVID-19 crisis. The present study was conducted in one hospital in Tehran, Iran. 20 Iranian nursing managers in all nursing management positions such as head nurse, matron and supervisor were interviewed. Semi-structured interview was conducted at one hospital in Iran, using reflective and open-ended questions. Interviews were audio recorded and transcribed. The study was carried out in 2020 while data saturation occurred, no new categories or codes have emerged and the study questions were answered. Credibility and conformability were established through member checking. The report of the analysis was returned to the participants in order to get the assurance that the researchers had portrayed their real world in codes and extracted categories.ResultsFour main themes emerged from data analysis including ‘managers as role model’, ‘full responsiveness’, ‘being in constant challenge’ and ‘post disaster growth’.ConclusionNursing management is one of the activities that the manager must be constantly aware of the activities of his subset. This requires a constant presence in the workplace and communication with nursing staff. Also, in times of crisis, the manager, in addition to having scientific ability, must also have sufficient experience. These two factors will lead to crisis management. Also, training staff and managers in crisis management is one of the most important issues in nursing management.
Hospitalisation for systemic lupus erythematosus associates with an increased risk of mortality in Australian patients from 1980 to 2014: a longitudinal, population-level, data linkage, cohort study
Authors: Raymond Warren David , Lester Susan , Preen David Brian , Keen Helen Isobel , Inderjeeth Charles Anoopkumar , Furfaro Michael , Nossent Johannes Cornelis 
Published: October 2021

ObjectiveMortality rates for patients with SLE have not been reported in Australia. This study determined the association between a hospitalisation for SLE with mortality.MethodsPopulation-level cohort study of patients with SLE (n=2112; 25 710 person-years) and general population comparators (controls) (n=21, 120; 280 637 person-years) identified from hospital records contained within the WA Rheumatic Disease Epidemiological Registry from 1980 to 2013. SLE was identified by ICD-9-CM: 695.4, 710.0, ICD-10-AM: L93.0, M32.0. Controls were nearest matched (10:1) for age, sex, Aboriginality and temporality. Using longitudinal linked health data, we assessed the association between a hospitalisation for SLE mortality and mortality with univariate and multivariate Cox proportional hazards and competing risks regression models.ResultsAt timezero, patients with SLE were similar in age (43.96 years), with higher representation of females (85.1% vs 83.4%, p=0.038), Aboriginal Australians (7.8% vs 6.0%) and smokers (20.5% vs 13.2%). Before study entry, patients with SLE (mean lookback 9 years) had higher comorbidity accrual (Charlson Comorbidity Index ≥1 item (42.0% vs 20.5%)), especially cardiovascular disease (CVD) (44.7% vs 21.0%) and nephritis (16.4% vs 0.5%), all p<0.001. During follow-up (mean 12.5 years), 548 (26.0%) patients with SLE and 2450 (11.6%) comparators died. A hospitalisation for SLE increased the unadjusted (HR 2.42, 95% CI 2.20 to 2.65) and multivariate-adjusted risk of mortality (aHR 2.03, 95% CI 1.84 to 2.23), which reduced from 1980 to 1999 (aHR 1.42) to 2000–2014 (aHR 1.27). Females (aHR 2.11), Aboriginal Australians (aHR 3.32), socioeconomically disadvantaged (aHR 2.49), and those <40 years old (aHR 7.46) were most vulnerable. At death, patients with SLE had a higher burden of infection (aHR 4.38), CVD (aHR 2.09) and renal disease (aHR 3.43), all p<0.001.ConclusionsA hospitalisation for SLE associated with an increased risk of mortality over the 1980–2014 period compared with the general population. The risk was especially high in younger (<40 years old), socioeconomically disadvantaged and Aboriginal Australians.
Machine learning approaches improve risk stratification for secondary cardiovascular disease prevention in multiethnic patients
Authors: Sarraju Ashish , Ward Andrew , Chung Sukyung , Li Jiang , Scheinker David , Rodríguez Fàtima 
Published: October 2021

ObjectivesIdentifying high-risk patients is crucial for effective cardiovascular disease (CVD) prevention. It is not known whether electronic health record (EHR)-based machine-learning (ML) models can improve CVD risk stratification compared with a secondary prevention risk score developed from randomised clinical trials (Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention, TRS 2°P).MethodsWe identified patients with CVD in a large health system, including atherosclerotic CVD (ASCVD), split into 80% training and 20% test sets. A rich set of EHR patient features was extracted. ML models were trained to estimate 5-year CVD event risk (random forests (RF), gradient-boosted machines (GBM), extreme gradient-boosted models (XGBoost), logistic regression with an L2 penalty and L1 penalty (Lasso)). ML models and TRS 2°P were evaluated by the area under the receiver operating characteristic curve (AUC).ResultsThe cohort included 32 192 patients (median age 74 years, with 46% female, 63% non-Hispanic white and 12% Asian patients and 23 475 patients with ASCVD). There were 4010 events over 5 years of follow-up. ML models demonstrated good overall performance; XGBoost demonstrated AUC 0.70 (95% CI 0.68 to 0.71) in the full CVD cohort and AUC 0.71 (95% CI 0.69 to 0.73) in patients with ASCVD, with comparable performance by GBM, RF and Lasso. TRS 2°P performed poorly in all CVD (AUC 0.51, 95% CI 0.50 to 0.53) and ASCVD (AUC 0.50, 95% CI 0.48 to 0.52) patients. ML identified nontraditional predictive variables including education level and primary care visits.ConclusionsIn a multiethnic real-world population, EHR-based ML approaches significantly improved CVD risk stratification for secondary prevention.
Upadacitinib in patients with psoriatic arthritis and an inadequate response to non-biological therapy: 56-week data from the phase 3 SELECT-PsA 1 study
Authors: McInnes Iain B , Kato Koji , Magrey Marina , Merola Joseph F , Kishimoto Mitsumasa , Pacheco-Tena César , Haaland Derek , Chen Liang , Duan Yuanyuan , Zueger Patrick , Liu John , Lippe Ralph , Pangan Aileen L , Behrens Frank 
Published: October 2021

BackgroundIn SELECT-PsA 1, a randomised double-blind phase 3 study, upadacitinib 15 mg and 30 mg were superior to placebo and non-inferior to adalimumab in ≥20% improvement in American College of Rheumatology (ACR) criteria at 12 weeks in patients with psoriatic arthritis (PsA). Here, we report 56-week efficacy and safety in patients from SELECT-PsA 1.MethodsPatients received upadacitinib 15 mg or 30 mg once daily, adalimumab 40 mg every other week for 56 weeks or placebo through week 24 switched thereafter to upadacitinib 15 mg or 30 mg until week 56. Efficacy endpoints included the proportion of patients achieving ≥20%/50%/70% improvement in ACR criteria (ACR20/50/70), ≥75%/90%/100% improvement in Psoriasis Area and Severity Index (PASI75/90/100), minimal disease activity (MDA) and change from baseline in modified total Sharp/van der Heijde Score. Treatment-emergent adverse events per 100 patient years (PY) were summarised.ResultsConsistent with results through week 24, ACR20/50/70, PASI75/90/100 and MDA responses were maintained with upadacitinib through week 56 and were generally numerically higher than with adalimumab; inhibition of radiographic progression was also maintained. Patients who switched from placebo to upadacitinib exhibited comparable improvements at week 56 as patients originally randomised to upadacitinib. The rates of serious adverse events were 9.1 events/100 PY with upadacitinib 15 mg and 12.3 events/100 PY with upadacitinib 30 mg. Two deaths were reported in each of the upadacitinib groups.ConclusionEfficacy across various domains of PsA were maintained with upadacitinib 15 mg and 30 mg through week 56 with no new safety signals observed.
Potential effect of beetroot juice supplementation on exercise economy in well-trained females
Authors: Forbes Stacey P.A. , Spriet Lawrence L. 
Published: October 2021

This study examined if acute dietary nitrate supplementation (140 mL beetroot juice, BRJ) would reduce oxygen consumption (V̇O2) during cycling at power outputs of 50 and 70% maximal oxygen consumption in 14 well-trained female Canadian University Ringette League athletes. BRJ had no effect on V̇O2 or heart rate but significantly reduced ratings of perceived exertion (RPE) at both intensities. Individually, 4 participants responded to BRJ supplementation with a ≥3% reduction in V̇O2 at the higher power output. Novelty: Acute BRJ supplementation did not improve exercise economy in well-trained females, but significantly reduced RPE. However, 4/14 subjects did respond with a ≥3% V̇O2 reduction.
Changing winter diet of Thick-billed Murres (Uria lomvia) in southwest Greenland, 1990s versus 2010s
Authors: Merkel Flemming Ravn , Linnebjerg Jannie Fries , Andersen Ole Gorm Norden , Huffeldt Nicholas Per , Jansen Teunis , Hedeholm Rasmus , Frederiksen Morten 
Published: October 2021

Southwest Greenland constitutes an internationally important wintering area for seabirds, including Thick-billed Murres (Uria lomvia (Linnaeus, 1758)), but their prey may be affected by the general warming of this sub-Arctic region. We compared murre diet collected in winter in the 1990s and in the 2010s around Nuuk, Greenland. Fish made up 36% of the diet (wet mass) and crustaceans 63% in the 1990s, changing to 22% and 78% in the 2010s, respectively. Capelin (Mallotus villosus (Müller, 1776)) was the dominant fish species, and the smaller contribution in the 2010s coincided with declining densities of capelin around Nuuk. The crustaceans were dominated by two krill species (Meganyctiphanes norvegica (M. Sars, 1857) and Thysanoessa inermis (Krøyer, 1846)). However, M. norvegica was only important in the 2010s (51% wet mass), while T. inermis was dominating the 1990s with 62% wet mass and only 23% in the 2010s. The dominance of M. norvegica in the 2010s confirmed our expectations of a gradual “borealization” of this region due to the generally warming sub-Arctic. The smaller contribution of fish in the diet may also support the hypothesis of deteriorating winter conditions for murres. Apart from the diet, plastic was found in 15% of the birds and 53% had parasitic nematodes.
Exploring multi-Higgs models with softly broken large discrete symmetry groups
Authors: de Medeiros Varzielas Ivo , Ivanov Igor P. , Levy Miguel 
Published: October 2021

AbstractWe develop methods to study the scalar sector of multi-Higgs models with large discrete symmetry groups that are softly broken. While in the exact symmetry limit, the model has very few parameters and can be studied analytically, proliferation of quadratic couplings in the most general softly broken case makes the analysis cumbersome. We identify two sets of soft breaking terms which play different roles: those which preserve the symmetric vacuum expectation value alignment, and the remaining terms which shift it. Focusing on alignment preserving terms, we check which structural features of the symmetric parent model are conserved and which are modified. We find remarkable examples of structural features which are inherited from the parent symmetric model and which persist even when no exact symmetry is left. The general procedure is illustrated with the example of the three-Higgs-doublet model with the softly broken symmetry group $$\Sigma (36)$$

Σ
(
36
)

.
Electrodynamics in noninertial frames
Authors: Obukhov Yuri N. 
Published: October 2021

AbstractThe electromagnetic theory is considered in the framework of the generally covariant approach, that is applied to the analysis of electromagnetism in noninertial coordinate and frame systems. The special-relativistic formulation of Maxwell’s electrodynamics arises in the flat Minkowski spacetime when the general coordinate transformations are restricted to a class of transformations preserving the Minkowski line element. The particular attention is paid to the analysis of the electromagnetism in the noninertial rotating reference system. For the latter case, the general stationary solution of the Maxwell equations in the absence of the electric current is constructed in terms of the two scalar functions satisfying the Poisson and the biharmonic equations with an arbitrary charge density as a matter source. The classic problem of Schiff is critically revisited.
Dynamical gravastars from the interaction between scalar fields and matter
Authors: Cabo Montes de Oca Alejandro , Suarez Fontanella Duvier , Valls-Gabaud David 
Published: October 2021

AbstractGravastars are configurations of compact singularity-free gravitational objects which are interesting alternatives to classical solutions in the strong gravitational field regime. Although there are no static star-like solutions of the Einstein–Klein–Gordon equations for real scalar fields, we show that dynamical gravastars solutions arise through the direct interaction of a scalar field with matter. Two configurations presented here show that, within the internal zone, the scalar field plays a role similar to a cosmological constant, while it decays at large distances as the Yukawa potential. Like classical gravastars, these solutions exhibit small values of the temporal metric component near a transitional radial value, although this behaviour is not determined by the de Sitter nature of the internal space-time, but rather by a slowly-varying scalar field. The scalar field-matter interaction is able to define trapping forces that rigorously confine the polytropic gases to the interior of a sphere. At the surface of these spheres, pressures generated by the field-matter interaction play the role of “walls” preventing the matter from flowing out. These solutions predict a stronger scattering of the accreting matter with respect to Schwarzschild black holes.
Temperature profile characterization with fluorescence lifetime imaging microscopy in a thermophoretic chip
Authors: Lee Namkyu , Afanasenkau Dzmitry , Rinklin Philipp , Wolfrum Bernhard , Wiegand Simone 
Published: October 2021

Abstract
This study introduces a thermophoretic lab-on-a-chip device to measure the Soret coefficient. We use resistive heating of a microwire on the chip to induce a temperature gradient, which is measured by fluorescence lifetime imaging microscopy (FLIM). To verify the functionality of the device, we used dyed polystyrene particles with a diameter of 25 nm. A confocal microscope is utilized to monitor the concentration profile of colloidal particles in the temperature field. Based on the measured temperature and concentration differences, we calculate the corresponding Soret coefficient. The same particles have been recently investigated with thermal diffusion forced Rayleigh scattering (TDFRS) and we find that the obtained Soret coefficients agree with literature results. This chip offers a simple way to study the thermophoretic behavior of biological systems in multicomponent buffer solutions quantitatively, which are difficult to study with optical methods solely relying on the refractive index contrast.

Graphic abstract
On the angular momentum and spin of generalized electromagnetic field for r-vectors in (k, n) space-time dimensions
Authors: Martinez Alfonso , Colombaro Ivano , Font-Segura Josep 
Published: October 2021

AbstractThis paper studies the relativistic angular momentum for the generalized electromagnetic field, described byr-vectors in (k, n) space-time dimensions, with exterior-algebraic methods. First, the angular-momentum tensor is derived from the invariance of the Lagrangian to space-time rotations (Lorentz transformations), avoiding the explicit need of the canonical tensor in Noether’s theorem. The derivation proves the conservation law of angular momentum for generic values ofr,k, andn. Second, an integral expression for the flux of the tensor across a$$(k+n-1)$$(k+n-1)-dimensional surface of constant$$\ell $$ℓ-th space-time coordinate is provided in terms of the normal modes of the field; this analysis is a natural generalization of the standard analysis of electromagnetism, i. e. a three-dimensional space integral at constant time. Third, a brief discussion on the orbital angular momentum and the spin of the generalized electromagnetic field, including their expression in complex-valued circular polarizations, is provided for generic values ofr,k, andn.
"How over is it?" Understanding the Incel Community on YouTube
Authors: Papadamou Kostantinos , Zannettou Savvas , Blackburn Jeremy , De Cristofaro Emiliano , Stringhini Gianluca , Sirivianos Michael 
Published: October 2021

YouTube is by far the largest host of user-generated video content worldwide. Alas, the platform has also come under fire for hosting inappropriate, toxic, and hateful content. One community that has often been linked to sharing and publishing hateful and misogynistic content are the Involuntary Celibates (Incels), a loosely defined movement ostensibly focusing on men's issues. In this paper, we set out to analyze the Incel community on YouTube by focusing on this community's evolution over the last decade and understanding whether YouTube's recommendation algorithm steers users towards Incel-related videos. We collect videos shared on Incel communities within Reddit and perform a data-driven characterization of the content posted on YouTube.
Among other things, we find that the Incel community on YouTube is getting traction and that, during the last decade, the number of Incel-related videos and comments rose substantially. We also find that users have a 6.3% chance of being suggested an Incel-related video by YouTube's recommendation algorithm within five hops when starting from a non Incel-related video. Overall, our findings paint an alarming picture of online radicalization: not only Incel activity is increasing over time, but platforms may also play an active role in steering users towards such extreme content.
A Combinatorial CRISPR–Cas9 Screen Identifies Ifenprodil as an Adjunct to Sorafenib for Liver Cancer Treatment
Authors: Xu Feng , Tong Man , Tong Cindy S.W. , Chan Becky K.C. , Chu Hoi Yee , Wong Tin Lok , Fong John H.C. , Cheung Maggie S.H. , Mak Kylie Hin-Man , Pardeshi Lakhansing , Huang Yuanhua , Wong Koon Ho , Choi Gigi C.G. , Ma Stephanie , Wong Alan S.L. 
Published: October 2021

Abstract

Systematic testing of existing drugs and their combinations is an attractive strategy to exploit approved drugs for repurposing and identifying the best actionable treatment options. To expedite the search among many possible drug combinations, we designed a combinatorial CRISPR–Cas9 screen to inhibit druggable targets. Coblockade of the N-methyl-d-aspartate receptor (NMDAR) with targets of first-line kinase inhibitors reduced hepatocellular carcinoma (HCC) cell growth. Clinically, HCC patients with low NMDAR1 expression showed better survival. The clinically approved NMDAR antagonist ifenprodil synergized with sorafenib to induce the unfolded protein response, trigger cell-cycle arrest, downregulate genes associated with WNT signaling and stemness, and reduce self-renewal ability of HCC cells. In multiple HCC patient-derived organoids and human tumor xenograft models, the drug combination, but neither single drug alone, markedly reduced tumor-initiating cancer cell frequency. Because ifenprodil has an established safety history for its use as a vasodilator in humans, our findings support the repurposing of this drug as an adjunct for HCC treatment to improve clinical outcome and reduce tumor recurrence. These results also validate an approach for readily discovering actionable combinations for cancer therapy.

Significance:
Combinatorial CRISPR–Cas9 screening identifies actionable targets for HCC therapy, uncovering the potential of combining the clinically approved drugs ifenprodil and sorafenib as a new effective treatment regimen.
Recreational Physical Activity, Sitting, and Androgen Metabolism among Postmenopausal Women in the Women's Health Initiative Observational Study
Authors: Oh Hannah , Saquib Nazmus , Ochs-Balcom Heather M. , Pfeiffer Ruth M. , Richey Phyllis A. , Shadyab Aladdin H. , Wild Robert A. , Underland Lisa , Anderson Garnet L. , Xu Xia , Trabert Britton 
Published: October 2021

Abstract

Background:
Prolonged sitting and physical inactivity are associated with higher circulating levels of estrogens. It is unknown whether these risk factors are associated with circulating androgens/androgen metabolites, another set of hormones implicated in the etiology of cancers in postmenopausal women.

Methods:
We conducted a cross-sectional analysis of 1,782 postmenopausal women in the Women's Health Initiative Observational Study. Serum concentrations of 12 androgens/androgen metabolites were quantified using liquid chromatography-tandem mass spectrometry. Physical activity and sitting time were self-reported at baseline. We performed linear regression to estimate geometric means (GM) of androgen/androgen metabolite concentrations (pmol/L) according to physical activity and sitting time, adjusting for potential confounders and stratified by menopausal hormone therapy (MHT) use.

Results:
Physical activity (≥15 vs. 0 MET-h/wk) was inversely associated with estrogen-to-androgen ratios among never/former MHT users (adj-GM = 37.5 vs. 49.6 unconjugated estrone:androstenedione; 20.2 vs. 30.3 unconjugated estradiol:testosterone; all Ptrend ≤ 0.03) but was not associated among current MHT users. Prolonged sitting (≥10 vs. ≤5 h/d) was positively associated with these ratios among both never/former (adj-GM = 44.2 vs. 38.3, Ptrend = 0.10; adj-GM = 23.4 vs. 20.2, Ptrend = 0.17; respectively) and current MHT users (adj-GM = 197 vs. 147; 105 vs. 75.5; respectively; all Ptrend ≤0.02), but the associations were statistically significant among current MHT users only. The associations persisted after adjustment for BMI. After adjustment for adrenal androgens, physical activity and sitting were not associated with androgen metabolites.

Conclusions:
Physical activity and sitting were associated with serum estrogen-to-androgen ratios but not androgen metabolites.

Impact:
This study contributes to our understanding of the link between physical activity, sitting, and cancer risk in postmenopausal women.