bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stimulation of Redox‐Induced Electron Transfer by Interligand Hydrogen Bonding in a Cobalt Complex with Redox‐Active Guanidine Ligand
Authors: Lohmeyer Lukas , Schön Florian , Kaifer Elisabeth , Himmel Hans‐Jörg 
Published: February 2021

AbstractOctahedrally coordinated cobalt(II) complexes with a redox‐active bisguanidine ligand and acac co‐ligands were synthesized and their redox chemistry analysed in detail. The N−H functions in a bisguanidine ligand with partially alkylated guanidino groups form N−H⋅⋅⋅O hydrogen bonds with the acac co‐ligands, thereby massively influencing the redox chemistry. For all complexes, the first one‐electron oxidation is metal‐centred, leading to CoIII complexes with neutral bisguanidine ligand units. Further one‐electron oxidation is ligand‐centred in the case of Co–bisguanidine complexes with fully alkylated guanidino groups, giving CoIII complexes with radical monocationic bisguanidine ligands. On the other hand, the hydrogen‐bond strengthening upon oxidation of the Co–bisguanidine complex with partially alkylated guanidino groups initiates metal reduction (CoIII→CoII) and two‐electron oxidation of the guanidine ligand, providing the first example for the stimulation of redox‐induced electron transfer by interligand hydrogen bonding.
Morphological, mechanical, and electromagnetic interference shielding effectiveness characteristics of glass fiber/epoxy resin/MWCNT buckypaper composites
Authors: Rojas Jefersson Alexander , de Paula Santos Luis Felipe , Botelho Edson Cocchieri , Ribeiro Bruno , Rezende Mirabel Cerqueira 
Published: February 2021

AbstractGlass fiber/epoxy resin composites (GF/EP) using one and three multi‐walled carbon nanotube buckypapers (BP) were obtained and their complex parameters, reflectivity, and electromagnetic interference (EMI) shielding effectiveness (SE) at X‐band (8.2–12.4 GHz) and Ku‐band (12.4–18 GHz) were evaluated. The preparation of BP used polyacrylonitrile (PAN) nanofibers (PF These composites show both large storage and energy loss capacity in both bands revealing promising results related to EMI SE applications. Besides, a high attenuation of around 67% and 72% were achieved for BP based composites. The cross‐section view of the buckypaper and the laminates was analyzed by scanning electron microscopy (SEM). The incorporation of the CNT film into the laminates showed no improvements in the elastic properties through dynamic mechanical analyses (DMA). Nevertheless, a decrease in the shear properties by the compression shear test (CST) and interlaminar shear strength (ILSS) has been observed. GF/EP/BP/PF composite presented a reduction of 29 and 39% in its ILSS properties compared to the base laminate (GF/EP). Also, the decrease was even more significant, revealing a steep reduction in its CST properties. On the other hand, the removal of the pan nanofiber (PF) led to better mechanical properties for GF/EP/BP/RPF composites. Results have shown ILSS values of 47.4 ± 2.2 MPa which are close to the base laminate (52.4 ± 3.1 MPa). The removal of the PF provided larger porous in the CNT network, making the impregnation by epoxy easier in the BP/RPF which resulted in improved shear properties compared to GF/EP/BP/PF samples.
A high Cr (VI) absorption efficiency and easy recovery adsorbent: Electrospun polyethersulfone/polydopamine nanofibers
Authors: Wei Zhimei , Zhang Shouyu , Wang Xiaojun , Long Shengru , Yang Jie 
Published: February 2021

AbstractCr (VI) is a highly toxic pollutant to humans, to achieve high adsorption capacity, easy recovery, and good reusability, polyethersulfone/polydopamine (PES/PDA) ultrafine fibers were prepared successfully. A series of preparing effect factors were investigated systematically and the optimum one is 8.5 pH value at room temperature and 2 g/L dopamine concentration. And then they were used as an adsorbent for the removal of Cr (VI) ions from wastewater. The effect factors pH, the adsorbent dosage, and time were discussed on Cr (VI) adsorption process and the Cr (VI) adsorption behavior was investigated. It is found that the maximum Cr (VI) adsorption capacity is 115.2 ± 4.8 mg/g at pH = 3 using 0.06 g PES/PDA with 80 mins. The Cr (VI) adsorption process followed the pseudo‐second‐order model (r2 ≥ 0.99) and adsorption isotherms were fitted to the Langmuir model (R2 ≥ 0.999). Furthermore, the Cr (VI) adsorption mechanism was supposed according to the X‐ray photoelectron spectroscopic results. Finally, PES/PDA ultrafine fibers were considered to be a promising adsorbent with good stability (decomposing temperature, 356°C), high adsorption efficiency (112.1 ± 2.5 mg/g), and good reusability (three times) on the coexistence of anions and the actual industry wastewater environment.
Open is not forever: A study of vanished open access journals
Authors: Laakso Mikael , Matthias Lisa , Jahn Najko 
Published: February 2021

AbstractThe preservation of the scholarly record has been a point of concern since the beginning of knowledge production. With print publications, the responsibility rested primarily with librarians, but the shift toward digital publishing and, in particular, the introduction of open access (OA) have caused ambiguity and complexity. Consequently, the long‐term accessibility of journals is not always guaranteed, and they can even disappear from the web completely. The focus of this exploratory study is on the phenomenon of vanished journals, something that has not been carried out before. For the analysis, we consulted several major bibliographic indexes, such as Scopus, Ulrichsweb, and the Directory of Open Access Journals, and traced the journals through the Internet Archive's Wayback Machine. We found 174 OA journals that, through lack of comprehensive and open archives, vanished from the web between 2000 and 2019, spanning all major research disciplines and geographic regions of the world. Our results raise vital concern for the integrity of the scholarly record and highlight the urgency to take collaborative action to ensure continued access and prevent the loss of more scholarly knowledge. We encourage those interested in the phenomenon of vanished journals to use the public dataset for their own research.
One‐pot Synthesis of Pd/Azo‐polymer as an Efficient Catalyst for 4‐Nitrophenol Reduction and Suzuki‐Miyaura Coupling Reaction
Authors: Yu Yanlin , Gong Yuzhu , Cao Binbin , Liu Haidong , Zhang Xiaoli , Han Xu , Lu Shuanglong , Cao Xueqin , Gu Hongwei 
Published: February 2021

AbstractThe porous polymer matrix with good stability and confined microenvironment is considered as ideal support to stabilize isolated metal centers for catalysis. Herein, we report a “one‐pot” method to prepare a kind of palladium complexed with azo porous organic polymer nanospheres (Pd‐azo‐POPs). The method combines the synthesis of azo‐POPs with the reduction of the Pd ion, where azo serves as an anchoring group to limit the growth of Pd. The unique structure is conductive to the formation of a uniform active center and provides improved electron transfer. Pd‐azo‐POPs‐80 exhibits a high catalytic activity and cycling stability both in 4‐nitrophenol reduction and Suzuki‐Miyaura coupling. The knor for the 4‐nitrophenol reduction was 174.7 min−1 mM−1 and the conversion remains above 90% after 6 cycles. Meanwhile, the yield was still up to 94.5% after 5 cycles for the Suzuki‐Miyaura coupling reaction of benzene derivatives with I/Br under mild conditions.
Alexithymia is related to poor social competence in autistic and nonautistic children
Authors: Scheerer Nichole E. , Boucher Troy Q. , Iarocci Grace 
Published: February 2021

AbstractAlexithymia is characterized by difficulties identifying and describing one's own emotions and the emotions of others. These challenges with understanding emotions in people with alexithymia may give rise to difficulties with social interactions. Given that alexithymia frequently co‐occurs with autism spectrum disorder (ASD), and that both populations have difficulties with social interactions, it is of interest to determine whether alexithymia can help to parse some of the heterogeneity in social competence in autistic and nonautistic individuals. The caregivers of 241 children (6–14 years old), including 120 autistic, and 121 nonautistic, rated their child's social competence using the Multidimensional Social Competence Scale (MSCS), autism traits using the Autism Spectrum Quotient (AQ), and alexithymia traits using the Children's Alexithymia Measure (CAM). Regression analyses indicated that age, IQ, sex, AQ, and CAM scores accounted for 40.2% of the variance in autistic children's, and 68.2% of the variance in nonautistic children's, parent‐reported social competence. Importantly, after controlling for age, IQ, sex, and AQ scores, CAM scores alone accounted for an additional 16.2% of the variance in autistic children's, and 17.4% of the variance in nonautistic children's social competence. These results indicate that higher alexithymia traits predict lower levels of social competence, suggesting that increased difficulty in identifying and describing one's own emotions and the emotions of others is associated with poorer social competence. Furthermore, CAM scores were found to partially mediate the relationship between autistic traits and social competence, suggesting that comorbid alexithymia traits may be partially responsible for poor social competence in individuals with high autistic traits. This research contributes to the understanding of the factors associated with the development of social competence and highlights alexithymia as a potential target for identification and intervention to improve social competence.Lay SummaryAlexithymia is a condition where people find it hard to think and talk about their (and others') feelings. About 50% of autistic people have alexithymia. This might be why they have social and emotional difficulties. Parents answered questions about alexithymia and social difficulties their children have. Children with more alexithymia problems had poorer social skills. Thus, alexithymia may be related to social problems faced by autistic and nonautistic children.
A CRISPR/Cas9 eraser strategy for contamination‐free PCR end‐point detection
Authors: Lin Wei , Tian Tian , Jiang Yongzhong , Xiong Erhu , Zhu Debin , Zhou Xiaoming 
Published: February 2021

AbstractPolymerase chain reaction (PCR), a central technology for molecular diagnostics, is highly sensitive but susceptible to the risk of false positives caused by aerosol contamination, especially when an end‐point detection mode is applied. Here, we proposed a solution by designing a clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 eraser strategy for eliminating potential contamination amplification. The CRISPR/Cas9 engineered eraser is firstly adopted into artpcr reverse‐transcription PCR (RT‐PCR) system to achieve contamination‐free RNA detection. Subsequently, we extended this CRISPR/Cas9 eraser to the PCR system. We engineered conventional PCR primers to enable the amplified products to contain an implanted NGG (protospacer adjacent motif, PAM) site, which is used as a code for specific CRISPR/Cas9 recognition. Pre‐incubation of Cas9/sgRNA with PCR mix leads to a selective cleavage of contamination amplicons, thus only the template DNA is amplified. The developed CRISPR/Cas9 eraser, adopted by both RT‐PCR and PCR systems, showed high‐fidelity detection of SARS‐CoV‐2 and African swine fever virus with a convenient strip test.
Implementation and characterization of a physiologically relevant flow waveform in a 3D microfluidic model of the blood–brain barrier
Authors: Bouhrira Nesrine , DeOre Brandon J. , Galie Peter A. 
Published: February 2021

AbstractPrevious in vitro studies interrogating the endothelial response to physiologically relevant flow regimes require specialized pumps to deliver time‐dependent waveforms that imitate in vivo blood flow. The aim of this study is to create a low‐cost and broadly adaptable approach to mimic physiological flow, and then use this system to characterize the effect of flow separation on velocity and shear stress profiles in a three‐dimensional (3D) topology. The flow apparatus incorporates a programmable linear actuator that superposes oscillations on a constant mean flow driven by a peristaltic pump to emulate flow in the carotid artery. The flow is perfused through a 3D in vitro model of the blood–brain barrier designed to induce separated flow. Experimental flow patterns measured by microparticle image velocimetry and modeled by computational fluid dynamics reveal periodic changes in the instantaneous shear stress along the channel wall. Moreover, the time‐dependent flow causes periodic flow separation zones, resulting in variable reattachment points during the cycle. The effects of these complex flow regimes are assessed by evaluating the integrity of the in vitro blood–brain barrier model. Permeability assays and immunostaining for proteins associated with tight junctions reveal barrier breakdown in the region of disturbed flow. In conclusion, the flow system described here creates complex, physiologically relevant flow profiles that provide deeper insight into the fluid dynamics of separated flow and pave the way for future studies interrogating the cellular response to complex flow regimes.
Exploring lipid biomarkers of coronary heart disease for elucidating the biological effects of gelanxinning capsule by lipidomics method based on LC–MS
Authors: Gao Xin , Hu Xiao‐hu , Zhang Qiong , Wang Xi‐jing , Wen Xiu‐hong , Wang Yuan , Zhang Yan‐xia , Sun Wen‐jun 
Published: February 2021

AbstractHigh‐throughput lipidomics technology was used to explore the potential therapeutic targets and mechanism of action of gelanxinning capsule on rat model with coronary heart disease (CHD). This study attempts to provide a novel method to interpret the molecular mechanism of traditional medicine. The lipid markers of CHD were determined by full‐scan analysis based on ultra‐performance liquid chromatography‐high‐definition mass spectrometry. Then, the metabolic changes associated with gelanxinning capsule treatment via the modulation of lipid biomarkers and pathway in rats were characterized. After gelanxinning treatment, the metabolic profile tended to recover compared with the model group. A total of 26 potential biomarkers were identified to represent the disorders of lipid metabolism in CHD animal model, of which 19 were regulated by gelanxinning capsule administration, and four metabolic pathways such as glycerophospholipid metabolism, sphingolipid metabolism, glycosylphosphatidylinositol‐anchor biosynthesis, and glycerolipid metabolism were involved. From the pathway analysis, it was found that glycerophospholipid metabolism and sphingolipid metabolism with significant differences have the potential to be regarded as new targets for the treatment of CHD. Gelanxinning capsule with its good therapeutic effect protects against CHD by regulating lipid biomarkers and pathway from lipidomics‐guided biochemical analysis.
Neurological symptoms in Covid‐19 patients in the emergency department
Authors: García‐Azorín David , Trigo Javier , Martínez‐Pías Enrique , Hernández‐Pérez Isabel , Valle‐Peñacoba Gonzalo , Talavera Blanca , Simón‐Campo Paula , de Lera Mercedes , Chavarría‐Miranda Alba , López‐Sanz Cristina , Gutiérrez‐Sánchez María , Martínez‐Velasco Elena , Pedraza María , Sierra Álvaro , Gómez‐Vicente Beatriz , Guerrero Ángel , Arenillas Juan Francisco 
Published: February 2021

AbstractBackgroundCoronavirus disease 2019 (Covid‐19) might present neurological symptoms. We aimed to evaluate the frequency of them at the moment of emergency department (ED) visit and their impact in the prognosis.MethodsRetrospective cohort study including all consecutive hospitalized cases between March 8th and April 11th, 2020. Covid‐19 diagnosis was confirmed by polymerase chain reaction test and/or serology. We compared, in patients with and without neurological symptoms on admission, demographic, clinical presentation, and frequency and type of abnormal laboratory values. We analyzed the variables that were associated with in‐hospital all‐cause mortality by Cox‐regression log‐rank test.ResultsWe included 576 hospitalized patients, 250 (43.3%) female, aged 67.2 years. At the moment of ED visit, 320 (55.6%) described neurological symptoms, including anosmia (146, 25.3%), myalgia (139, 24.1%), headache (137, 23.8%), and altered mental status (98, 17.0%). Neurological symptoms started the first symptomatic day in 198 (54.2%) cases. Patients with neurological symptoms presented later to the ED (7.9 versus. 6.6 days, p = .019). Only four (0.6%) cases had no typical Covid‐19 general symptoms, and only six (1.9%) had a normal laboratory results, for a sensitivity of 98.7% (95% confidence interval (CI): 96.6%–99.6%) and 98.1% (95% CI: 95.7%–99.2%), respectively. In the multivariate Cox‐regression of mortality predictors, anosmia (HR: 0.358, 95%CI: 0.140–0.916) and altered mental status (HR: 1.867, 95%CI: 1.162–3.001) were significant.ConclusionNeurological symptoms were the most frequent extrapulmonary symptoms. They were present in half of the Covid‐19 patients at the time of the ED visit. Anosmia on admission was an independent predictor of lower in‐hospital mortality and altered mental status on admission predicted in‐hospital mortality.
Serum neurofilament light chain in chronic inflammatory demyelinating polyneuropathy
Authors: Hayashi Tomohiro , Nukui Takamasa , Piao Jin‐Lan , Sugimoto Tomoyuki , Anada Ryoko , Matsuda Noriyuki , Yamamoto Mamoru , Konishi Hirofumi , Dougu Nobuhiro , Nakatsuji Yuji 
Published: February 2021

AbstractObjectivesNeurofilament light chain (NfL) levels have been suggested as reflecting axonal damage in various inflammatory and neurodegenerative disorders, including acquired peripheral neuropathies. We aimed to investigate if serum NfL (sNfL) levels can be a biomarker of disease activity and treatment response in patients with chronic inflammatory demyelinating polyneuropathy (CIDP).Materials and methodsThe sNfL levels of eleven newly diagnosed patients with CIDP were retrospectively assayed and compared with seven healthy volunteers. The levels were assayed before and after intravenous immunoglobulin treatment in patients with CIDP and were also assayed in the remission period.ResultsBaseline sNfL levels in patients with CIDP before treatment were significantly higher than those in healthy controls. The levels significantly decreased overtime after one month of treatment and in remission period. There were significant negative correlations between the sNfL levels and the disease duration (the interval between the onset of the disease and the time of sampling), and weak correlations between the sNfL levels and overall neuropathy limitations scale.ConclusionssNfL may be a potential biomarker reflecting the disease activity in patients with CIDP.
Consumers' self‐construal: Measurement and relevance for social media communication success
Authors: Hofmann Verena , Schwayer Lisa Marie , Stokburger‐Sauer Nicola E. , Wanisch Anna Teresa 
Published: February 2021

AbstractTo determine the relevance of consumers' self‐construal in social media contexts, this study investigates its effects on social media success metrics, such as sharing behaviour, as well as its influence on the relationship between social media success and other drivers, such as endorsers' emotion displays or the communication source (user vs. company). Along with an in‐depth review of consumers' self‐construal, this article reports on two quantitative panel studies, which reveal that eight items are best suited to represent consumers' self‐construal, using correlated dimensions of interdependent and independent self‐construal. The main study affirms the relevance of consumers' self‐construal and offers detailed insights. Consumers with a strong interdependent self‐construal express more positive attitudes toward social media posts, and a smiling endorser positively influences attitudes toward the post, sharing behaviour, word of mouth, and purchase intention. In combination, a strong interdependent self‐construal and smiling endorser produce even stronger effects for attitudes toward the post, purchase intention, and word of mouth. User‐generated content outperforms company‐generated content, independent of self‐construal types. These findings have important implications for social media communication management and personality research.
Approaches to Evaluate the Impact of a Small‐Molecule Binder to a Noncatalytic Site of the Proteasome
Authors: Tian Wenzhi , Maresh Marianne E. , Trader Darci J. 
Published: February 2021

AbstractProteasome activity is crucial for cell survival and proliferation. In recent years, small molecules have been discovered that can affect the catalytic activity of the proteasome. Rather than targeting the active sites of the proteasome, it might be possible to affect ubiquitin‐dependent degradation of proteins by limiting the association of the 19S regulatory particle (19S RP) with the 20S core particle (20S CP) of the proteasome. We recently described the discovery of TXS‐8, a peptoid that binds to Rpn‐6. Rpn‐6 is a proteasome‐associated protein that makes critical contacts with the 19S RP and the 20S CP. Herein, we present a general workflow to evaluate the impact of a small‐molecule binder on proteasome activity by using TXS‐8 as an example. This workflow contains three steps in which specific probes or overexpressed proteins in cells are used to determine whether the hydrolysis activity of the proteasome is affected. Although, in our case, TXS‐8 did not affect proteasome activity, our workflow is highly amenable to studying a variety of small‐molecule–proteasome subunit interactions.
Manufacture of Multilayered Artificial Cell Membranes through Sequential Bilayer Deposition on Emulsion Templates
Authors: Ip Tsoi , Li Qien , Brooks Nick , Elani Yuval 
Published: February 2021

AbstractEfforts to manufacture artificial cells that replicate the architectures, processes and behaviours of biological cells are rapidly increasing. Perhaps the most commonly reconstructed cellular structure is the membrane, through the use of unilamellar vesicles as models. However, many cellular membranes, including bacterial double membranes, nuclear envelopes, and organelle membranes, are multilamellar. Due to a lack of technologies available for their controlled construction, multilayered membranes are not part of the repertoire of cell‐mimetic motifs used in bottom‐up synthetic biology. To address this, we developed emulsion‐based technologies that allow cell‐sized multilayered vesicles to be produced layer‐by‐layer, with compositional control over each layer, thus enabling studies that would otherwise remain inaccessible. We discovered that bending rigidities scale with the number of layers and demonstrate inter‐bilayer registration between coexisting liquid–liquid domains. These technologies will contribute to the exploitation of multilayered membrane structures, paving the way for incorporating protein complexes that span multiple bilayers.