bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative study on the nursery culture of hatchery-reared sub-adult cupped oyster, Crassostrea iredalei (Faustino, 1932), in an earthen pond and a mangrove canal
Authors: Chueachat Premwadee , Tarangkoon Woraporn , Tanyaros Suwat 
Published: April 2021

Abstract
A comparative study on the nursery culture of the spat of the tropical oyster, Crassostrea iredalei, in an earthen pond and a mangrove canal was conducted over two months. The results revealed no differences in the absolute growth rate determined by shell width between the two culture sites (P < 0.05). Sub-adult oysters cultured in the mangrove canal showed a higher absolute growth rate in shell length and a higher daily growth rate than the oysters cultured in the earthen pond (P < 0.05). The mean survival rate of sub-adult oysters cultured in the earthen pond (99.8 ± 0.2%) was significantly higher than for those cultured in the mangrove canal (66.7 ± 31.4%). Decreased density from the loss of sub-adult oyster nursery culture in the mangrove canal led to higher growth performance than in the earthen pond. However, no difference was found for the fraction of oysters larger or smaller than 5 cm for the two culture sites (P < 0.05). A significant difference was noted in the Condition Index (CI) between the two culture sites (P < 0.05). The high primary productivity in mangroves is a major supporter of higher CI in sub-adult oysters cultured in mangrove canals versus in earthen ponds. Water exchange in the earthen pond to maintain calcium and magnesium concentrations resulted in no differences in the shell compressibility of sub-adult oysters compared with those cultured in the mangrove canal.
Opportunistic alien catfish: unexpected findings in the diet of the alien species Ictalurus punctatus in Central Italy
Authors: Haubrock Phillip J. , Azzini Martina , Fribbi Ivan , Inghilesi Alberto F. , Tricarico Elena 
Published: April 2021

Abstract
Alien fish species are known for the negative impacts they can have on native species and their ability to shape recipient communities. One such case is the North American channel catfish, Ictalurus punctatus (Raf.), in the Arno River in central Italy. During river bank reconstruction, specimens of this species (n=40) were collected, and the stomach content was analysed. As a result, we highlight the opportunistic feeding behavior of this alien species that is responding rapidly to newly available resources and also poses a threat to native species.
In vivo Antioxidant and Hepato-Protective Properties of Stem Bark Methanol Extract of Vitex doniana
Authors: Mailafiya Simon C. , Kolawole Sherifat O. , Adeniyi Abdulazeez K. , Muhammed Bala A. , Ismail Abdulfatai , Alawode Adenike R. , Lawal Bashir 
Published: April 2021

Abstract
The harmful effects that accompany the use of orthodox antioxidant medicine have necessitated the hunt for inherent antioxidants from plants extracts. In the present study, the in vivo antioxidant and hepato-protective activities of Vitex doniana against carbon tetrachloride (CCl4) induced liver damage in albino rats were investigated. The hepato-protective activities of the methanol extract of Vitex doniana stem bark were compared with Silymarin, a known hepatoprotective drug. Twenty-five (25) male albino adult rats were grouped into five (5) each. Group 1 and 2 was used as the normal and negative control respectively. Group 3-5 were treated with 200 mg/kg, 400 mg/kg methanol extract of Vitex doniana stem bark and 100 mg/kg Silymarin respectively. Results indicated that elevated levels of serum ALT, AST and ALB, and reduced serum SOD, GST and CAT in CCl4-hepatotoxic rats was an evidence of impairment in liver function. Administration of methanol extract of Vitex doniana stem bark (200 and 400 mg/kg body weight) and standard control drug Silymarin (100 mg/kg) have no significant (P>0.05) effect on CCl4- induced elevations of the ALT and AST levels while the reduction in albumin concentration, total proteins, SOD, GST and CAT due to CCl4 was reversed. In conclusion, Vitex doniana exhibited significant antioxidant and hepatoprotective properties in CCL4 induced liver damage in rat, and thus could be used and incorporated in the development of new and effective antioxidant drugs.
Geophysical Assessment of Groundwater Vulnerability to Diesel Contamination at a Telecommunication Mast in Adebayo Area, Ado-Ekiti, Southwestern Nigeria
Authors: Olayiwola Olaseeni , Tokunbo Fagbemigun , Bosede Ojo , Joel Amosun , Ajibola Oyebamiji 
Published: April 2021

Abstract
An appraisal of the groundwater vulnerability to contamination risk at Adebayo in Ado-Ekiti, Southwestern Nigeria, was carried out using the electrical resistivity method of geophysical prospecting. Two traverses of length 100 m each were established for both vertical electrical sounding (VES) and dipole-dipole. Six (6) Vertical Electrical Sounding (VES) and 2-D dipole-dipole profiling techniques of the electrical resistivity method were adopted for the geophysical investigation. The results show variations in resistivity values, depicting four to five geologic layers: the topsoil, laterite, weathered layer, fractured, and the fresh basement. It was observed from the correlation of the geoelectric section and 2-D resistivity image along traverse 1 (TR1) that the groundwater in the study area flows towards the southwestern part, and the fractured basement serves as a migration pathway to the diesel oil in the same direction as groundwater flow. The fractured basement (Well 2) with no lateritic cover has higher resistivity values compare to the fracture zone that was found directly under the mast which was overlain by the laterite. Comparing the resistivity values of Well 1 and 2, Well 2 that was drilled into the fractured basement has more traces of the contaminant than Well 1.
Cellulose fibers extraction from Ulva lactuca from the Black Sea
Authors: Tirpan Doiniţa-Roxana Cioroiu , Koncsag Claudia Irina , Dobre Tănase 
Published: April 2021

Abstract
Cellulose fibres are known for their good mechanical properties, therefore they are used as fillers in structural composite materials, including as nanofibrils in nanomaterials. Also, they are biocompatible, non-toxic and biodegradable, reason for their use in the food industry as packaging materials or in obtaining medical materials. One source of cheap, easy- to- extract cellulose is the algal mass of Ulva lactuca, one of the most frequent species found in the Black Sea. In this study, cellulose extraction from Ulva lactuca was achieved by a simple low cost physical-chemical treatment. Freshly harvested seaweed was dried at 45 °C for 48 hours, transformed into a fine powder in order to increase the contact surface between the solvents and the alga. Extraction of lipids and chlorophyll took place in Soxhlet apparatus with ethanol. Successive steps of chemical treatment, having in view removal of hydrosoluble ulvans, pigments and hemicellulose lead to a yield of 15.36% in dry matter (DM) of cellulose-rich insoluble fraction proving that Ulva Lactuca species is a viable alternative resource in cellulose production.
Existence and uniqueness of positive solution for nonlinear difference equations involving p(k)-Laplacian operator
Authors: Moghadam Mohsen Khaleghi , Wieteska Renata 
Published: April 2021

Abstract
In this paper, we deal with the existence of at least one and of at least two positive solutions as well the uniqueness of a positive solution for an anisotropic discrete non-linear problem involving p(k)-Laplacian with Dirichlet boundary value conditions. The technical approach for the existence part is based on a local minimum theorem and on a two critical points theorem for differentiable functionals, and for uniqueness part is based on a Lipschitzian continuous condition on the nonlinearity term.
Hyperideal theory in ordered Krasner hyperrings
Authors: Omidi Saber , Davvaz Bijan 
Published: April 2021

Abstract
In this paper, we study some properties of ordered Krasner hyper-rings. Also we state some definitions and basic facts and prove some results on ordered Krasner hyperring (R, +, ·, ≤). In particular, we introduce the concepts of prime hyperideals and semiprime hyperideals of an ordered Krasner hyperring and present several examples of them.
East-Central Europe in the Writing of James Clarence Mangan
Authors: Sturgeon Sinéad 
Published: April 2021

Abstract
This study explores the significance of East-Central Europe in a range of James Clarence Mangan’s poetry and prose from 1838–1847, focusing particularly on his depiction of Biedermeier Vienna (in the short story “The Man in the Cloak”), revolutionary uprisings in Poland and Albania (in the poems “Siberia” and “Song of the Albanian”), and his translations from the work of Bohemian-born Viennese poet Joseph Christian Freiherr von Zedlitz (1790–1862). I argue that Mangan’s interest in this region is twofold. On the one hand, it stems from the amenability of East-Central European culture and writing to the themes and tropes of the gothic, a genre central to Mangan’s imagination; on the other, from an underlying affinity in the historical position of the Irish and East-European poet in negotiating complex and contested politics of identity. While Mangan is a poet keenly conscious of “the importance of elsewhere,” and closely engaged in contemporary continental politics, I suggest that these European elsewheres also function as Foucauldian heterotopias, mythopoetic mirrors that enable the poet both to participate in Irish cultural nationalism and to register his dissent and distance from it.
Spatial differentiation of public administration employees due to professional burnout
Authors: Bąk Iwona , Wawrzyniak Katarzyna 
Published: April 2021

Abstract
The paper presents the results of classifying public administration employees in terms of level of occupational burnout, taking into account their place of residence, gender and age. One of the methods of multidimensional statistical analysis – classification trees – was used as a research tool. Two dependent variables are defined. The first has only two variants, defined as “no occupational burnout” and “occupational burnout”, which characterise all respondents. The second dependent variable was limited to those respondents diagnosed with occupational burnout and has four variants corresponding to intensity of burnout. The obtained results indicate the differentiation of voivodeships (first-order administrative regions) in terms of the level of the studied phenomenon.
Walnut Kernel administration to mothers during pregnancy and lactation improve learning of their pups. Changes in number of neurons and gene expression of NMDA receptor and BDNF in hippocampus in 80 days rat pups
Authors: Mahmoodian Zahra , Shekaari Majid Asadi , Soleimani Mansooreh , Ahmadi-Zeidabadi Meysam , Moradi Fatemeh , Akbarnejad Zeinab , Esmaeilpour Khadijeh , Kalantaripour Taj Pri 
Published: April 2021

Abstract
Walnut (Juglans regia) from the Juglandaceae family contains high levels of omega 3 fatty acid, vitamin E and melatonin, hence its consumption is beneficial to would be mothers and their offspring. The current study was designed to determine the possible mechanism of walnut consumption by mothers during pregnancy and lactation and the positive effects on learning and memory processes in their offspring. Wistar adult female rats were placed into three groups: control (fed with pellet, 20 g daily during pregnancy and lactation), CASE 1 [fed with Walnut Kernel (WK) 6% of food intake during pregnancy and lactation] and CASE 2 (fed with WK, 9% of food intake during gestation and lactation). In order to evaluate offspring learning and memory, the Morris Water Maze (MWM) test was performed for their adult offspring at 80 days of age. Histological and molecular studies were utilized in order to discover the protective mechanism and efficacy of WK consumption. The results revealed that learning was significantly improved in the females of CASE 2, in comparison to controls, while there was no difference in memory among the different groups. In addition, the number of neurons significantly increased in the CASE 2 group compared to the control group. However, the molecular study demonstrated that there was no significant difference among the study groups. The results herein show that feeding mothers with WK may improve the learning competence of their pups and increase the number of neurons in both sexes.
The effect of Ketogenic diet on vitamin D3 and testosterone hormone in patients with diabetes mellitus type 2
Authors: Almsaid Hayder , Khalfa Hydar Muhsin 
Published: April 2021

Abstract
A keto diet is well-known for being a low carb diet in which the body produces ketones in the liver to be used as energy. When something high in carbs is eaten, the body will produce glucose and insulin. Glucose is the easiest molecule for the body to convert and use as energy, so it will be chosen over any other energy source. The aim of this study is to examine the effect of a ketogenic diet on type 2 diabetic patients and the effect it has on testosterone, vitamin D3, HDL, LDL levels, in comparison to non-ketogenic diet subjects. In the study, Type 2 diabetic patients undergoing a keto diet were selected and serum D3 levels and testosterone levels were examined and compared with control subjects. The result show a significant increase in testosterone hormone in patients with diabetes mellitus type 2 following a Ketogenic diet (mean± Std. Error 427.4±2.52) as compared with the control group (mean ± Std. Error 422.2±0.24) and as compared with patients with diabetes mellitus type 2 who are not following a Ketogenic diet (mean± Std. Error 151.4±1.41). The results show no significant level in LDL level in patients with diabetes mellitus type 2 following a Ketogenic diet (mean ± Std. Error 78.53±0.17), as compared to a control group (mean ± Std. Error 75.0.3±0.14) and no significant level in HDL level in patients with diabetes mellitus type 2 following a Ketogenic diet (mean± Std. Error 46.3±1.55), as compared with a control group (mean ± Std. Error 46.2±2.43), and with patients with diabetes mellitus type 2 who are not following a Ketogenic diet (mean ± Std. Error 45.1±1.55). The results show a significant increase in vitamin D3 level in patient with diabetes mellitus type 2 who are following a Ketogenic diet (mean ± Std. Error 53.5±0.32), as compared with a control group (mean± Std. Error 57±0.24), and with patients with diabetes mellitus type 2 who are not following a Ketogenic diet (mean ± Std. Error 25.1±1.55). Herein, normal vitamin D3 levels in patients corresponds to normal testosterone hormone levels. In conclusion, this study shows that in patients with diabetes mellitus type 2, following a ketogenic diet has a positive effect on the patients’ health.
Reversal effect of Solanum dasyphyllum against rotenone-induced neurotoxicity
Authors: Ilesanmi Omotayo B. , Efe Obade , Odewale Temitope T. , Atanu Francis O. , Adeogun Esther F. , Akinmoladun Afolabi C. , Olaleye Tolulope M. 
Published: April 2021

Abstract
We earlier reported the protective effect of Solanum dasyphyllum against cyanide neurotoxicity. In furtherance to this, we investigated the protective effect of S. dasyphyllum against rotenone, a chemical toxin that causes brain-related diseases. Mitochondria fraction obtained from the brain of male Wistar rats was incubated with various solvents (hexane, dichloromethane, ethylacetate, and methanol) extracts of S. dasyphyllum before rotenone exposure. Mitochondria respiratory enzymes (MRE) were evaluated along with markers of oxidative stress. The inhibition of MRE by rotenone was reversed by treatment with various fractions of S. dasyphyllum. The oxidative stress induced by rotenone was also reversed by fractions of S. dasyphyllum. In addition, the ethylacetate fraction of S. dasyphyllum was most potent against rotenone-induced neurotoxicity. In conclusion, S. dasyphyllum is rich in active phytochemicals that can prevent some neurotoxic effects of rotenone exposure. Further study can be done in an in vivo model to substantiate our results.
Assessment of safety and effectiveness of oral morphine on patients attending pain and palliative care: a study on Indian population
Authors: Jayan Sreelakshmi , Stephen Stephy , Koshy Kevin Tom , Abraham Nikhil John , Daniel Sunitha , Anila K N 
Published: April 2021

Abstract
Opioid analgesics remain the corner stone of effective management of moderate to severe pain. Morphine in its oral and parenteral form is one of the most affordable options left to treat severe cancer pain in most Palliative centres in India. The main objective of our study was to assess the safety and effectiveness, as well as the prescribing pattern of immediate release oral morphine on the Indian population attending Pain and Palliative Care in a multi-speciality hospital. Within the sample population, 74.8% of all patients achieved a pain score reduction of less than or equal to 3 within the 72nd hour. Although the mean baseline pain score was similar in the cancer (8.23±0.75) and the non-cancer (8.26±0.98) group, the mean pain score at the 24th and 72nd hours were significantly different (5.6±1.29 in cancer and 5.09±1.26 in the non-cancer group within the 24th hour, followed by 3.66±1.479 and 3.12±0.88 after the 72nd hour, respectively). The majority of the patients (58.3%) were prescribed at a frequency of 5 mg every 4th hourly, with double dose at bedtime. A similar prescribing trend was seen in both the cancer and non-cancer groups. Moreover, 14 patients underwent dose escalation – with 12 belonging to the cancer group, while 11 patients falling under the cancer group required a switch to different therapy. The major adverse drug reactions (ADR) observed in both study groups were constipation (89.2%), fatigue (37.4%), dry mouth (36%) and nausea/vomiting (23%). The severity of nausea/vomiting and sleepiness was higher in the cancer group whereas itching was more predominant among the non-cancer group.
The role of Toll-like receptors (TLRs) in virus-related cancers: a mini review
Authors: Dworzanska Anna , Polz-Dacewicz Małgorzata 
Published: April 2021

Abstract
The modulation of the host innate immune system is a well-established carcinogenesis feature of several tumors, including human Epstein-Barr (EBV) and Papillomavirus-(HPV) related cancers. These viruses are able to interrupt the initial events of the immune response, including the expression of Toll-like receptors (TLRs), cytokines, and inflammation. The aim of the study is to review current data and summarize knowledge on the TLRs and their role in the development of cancer, especially viral-related cancers (EBV and HPV). Research work shows a correlation between the TLRs polymorphism and the development of oropharyngeal and gastric cancer (GC), especially related to viral infections. Many studies suggest the important role for TLRs in inflammatory, autoimmune disease and human cancers. However, further efforts are necessary to draw a precise conclusion.
Optimization of the composition of solid dispersion of quercetin
Authors: Kovalevska Inna , Ruban Olena , Kutova Olga , Levachkova Julia 
Published: April 2021

Abstract
Increasing the solubility of drugs is one of the most important problems in pharmacy, because most manufactured pharmaceutical substances are sparingly soluble. Typically, such compounds represent Classes II and IV in the biopharmaceutical classification system, which is based on the classification of pharmaceutical substances by solubility and permeability. For poorly soluble substances, the limiting step of the absorption process is usually the degree and dissolution rate, so in the pharmaceutical development, much attention is paid to their improvement. To solve this problem, the technology of solid dispersions creation is used. The aim of the work was to optimize the composition of quercetin solid dispersion, whose therapeutic use is limited due to its degree of solubility in an aqueous medium.
Objects of the study were samples of solid dispersions of quercetin with different carriers: polyethyleneoxide-6000, β-cyclodextrin and polyvinylpyrrolidone obtained in a ratio of 1:1 and 1:2 by liquid phase method, with and without the addition of a solvent. As a solvent, ethanol was used. To determine the optimal composition of solid dispersions, a mathematical planning method using the MathCad package and Excel software was used.
In the work, a dispersion analysis was performed upon the results of the experimental studies. The ranked series of advantages of the carrier and solvent influence on solubility of solid dispersions samples are shown. To determine the amount of carrier in the solid dispersion, the theory of multi-vector optimization was applied. According to the results of the conducted studies, the optimal value of quercetin and PEO-6000 ratio is 1:2.
The obtained results can be used in the development of the composition and technology of solid dispersions of active pharmaceutical ingredients insoluble in the aqueous medium.
Peculiarities of the effects of a high-calorie diet on the structural components of the lymph nodes and under melatonin correction
Authors: Harapko Tetiana , Mateshuk-Vatseba Lesia 
Published: April 2021

Abstract
Obesity is a chronic recurrent disease that is manifested by excess accumulation of adipose tissue and is a consequence of an imbalance in energy utilization and consumption in persons with or without hereditary predisposition. The purpose of the study is to study the morphometric and histological changes of the parenchyma of the lymph nodes of rats in experimental obesity and under the conditions of melatonin correction. The study was performed on 66 white rats of reproductive age. Microanatomy of the structural components of lymph nodes of white rats under physiological norms was examined in 10 intact animals. Experimental animals were divided into 4 groups. Eight weeks after the experimental animals were on a high calorie diet (HCD), there was a significant decrease in the relative area of the cortical substance in the parenchyma of the lymph nodes of white rats of males and females by 10.3% and 8.3%, respectively, and an increase in the relative area of the medullary substance by 16.1% and 13.2%, respectively, compared to an intact group of animals.
The relative area of the cortical substance in the parenchyma of the lymph nodes of white rats, which were for two weeks on HCD, then six weeks on HCD and melatonin, exceeds the parameters of the intact group of animals by only 3.2% in males and 3.5% in females. The relative area of the medullary substance is less than that of the intact group of animals by 5.0% in males and 5.5% in females. Under the conditions of melatonin correction it is found that the germinal centers of the secondary lymph nodes in the cortical substance are slightly increased. Trabecules extending from the capsule are clearly expressed and thickened, while arteries and arterioles show thickened walls and are full-blooded. Moreover, the veins are enlarged and full-blooded.
A massive malignant phyllodes tumor – case study
Authors: Madej-Czerwonka Barbara 
Published: April 2021

Abstract
The paper aims to introduce the case of an extensive breast malignancy – phyllodes tumor. This type of breast neoplasm is relatively rare. Indeed, it accounts for only 0.3-1% of all breast malignant tumours. In the paper, patient, disease, and treatment methods were described and evaluated. The efficacy of surgical treatment and adjuvant therapy (radiotherapy and chemotherapy) was assessed based on literature data. The authors concluded that late diagnosis of phyllodes tumor causes the necessity of mastectomy and radiotherapy and aggravates the prognosis.