bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diversity‐Oriented Synthesis of [2.2]Paracyclophane‐derived Fused Imidazo[1,2‐a]heterocycles by Groebke‐Blackburn‐Bienaymé Reaction: Accessing Cyclophanyl Imidazole Ligands Library
Authors: Stahlberger Mareen , Schwarz Noah , Zippel Christoph , Hohmann Jens , Nieger Martin , Hassan Zahid , Bräse Stefan 
Published: November 2021

AbstractThis report describes the synthesis of a [2.2]paracyclophane‐derived annulated 3‐amino‐imidazole ligand library through a Groebke‐Blackburn‐Bienaymé three‐component reaction (GBB‐3CR) approach employing formyl‐cyclophanes in combination with diverse aliphatic and aromatic isocyanides and heteroaromatic amidines. The GBB‐3CR process gives access to skeletally‐diverse cyclophanyl imidazole ligands, namely 3‐amino‐imidazo[1,2‐a]pyridines and imidazo[1,2‐a]pyrazines. Additionally, a one‐pot protocol for the GBB‐3CR by an in situ generation of cyclophanyl isocyanide is demonstrated. The products were analyzed by detailed spectroscopic techniques, and the cyclophanyl imidazo[1,2‐a]pyridine was confirmed unambiguously by single‐crystal X‐Ray crystallography. The cyclophanyl imidazole ligands can be readily transformed to showcase their useful utility in preparing N,C‐palladacycles through regioselective ortho‐palladation.
The effects of CD148 Q276P/R326Q polymorphisms in A431D epidermoid cancer cell proliferation and epidermal growth factor receptor signaling
Authors: He Lilly , Takahashi Keiko , Pasic Lejla , Narui Chikage , Ellinger Philipp , Grundmann Manuel , Takahashi Takamune 
Published: November 2021

AbstractBackgroundCD148 is a transmembrane protein tyrosine phosphatase that is expressed in multiple cell types. Previous studies have shown that CD148 dephosphorylates growth factor receptors and their signaling molecules, including EGFR and ERK1/2, and negatively regulates cancer cell growth. Furthermore, research of clinical patients has shown that highly linked CD148 gene polymorphisms, Gln276Pro (Q276P) and Arg326Gln (R326Q), are associated with an increased risk of several types of cancer. However, the biological effects of these missense mutations have not been studied.AimWe aimed to determine the biological effects of CD148 Q276P/R326Q mutations in cancer cell proliferation and growth factor signaling, with emphasis on EGFR signaling.MethodsCD148 forms, wild‐type (WT) or Q276P/R326Q, were retrovirally introduced into A431D epidermoid carcinoma cells that lacks CD148 expression. The stable cells that express comparable levels of CD148 were sorted by flow cytometry. A431D cells infected with empty retrovirus was used as a control. CD148 localization, cell proliferation rate, EGFR signaling, and the response to thrombospondin‐1 (TSP1), a CD148 ligand, were assessed by immunostaining, cell proliferation assay, enzyme‐linked immunosorbent assay, and Western blotting.ResultsBoth CD148 forms (WT, Q276P/R326Q) were distributed to cell surface and all three cell lines expressed same level of EGFR. Compared to control cells, the A431D cells that express CD148 forms showed significantly lower cell proliferation rates. EGF‐induced EGFR and ERK1/2 phosphorylation as well as cell proliferation were also significantly reduced in these cells. Furthermore, TSP1 inhibited cell proliferation in CD148 (WT, Q276P/R326Q)‐expressing A431D cells, while it showed no effects in control cells. However, significant differences were not observed between CD148 WT and Q276P/R326Q cells.ConclusionOur data demonstrates that Q276P/R326Q mutations do not have major effects on TSP1‐CD148 interaction as well as on CD148's cellular localization and activity to inhibit EGFR signaling and cell proliferation.
A novel fuzzy and reverse auction‐based algorithm for task allocation with optimal path cost in multi‐robot systems
Authors: K Rajchandar , R Baskaran , Panchu K Padmanabhan , M Rajmohan 
Published: November 2021

AbstractOne of the most frequent issues in multiple robot implementation is task allocation with the lowest path cost. Our study addresses the multi‐robot task allocation challenge with path costs, the lowest computing time, and task distribution. Furthermore, it is usual for a robot's processing capabilities to be restricted to operate in various target environments. As a consequence, adequate processing power consumption would demonstrate the system's efficiency. Task allocation and path planning issues must be addressed regularly to ensure multi‐robot system operation. Task allocation and path planning issues must be addressed regularly to ensure multi‐robot system operation. The above‐mentioned serious challenge gets more complicated when system factors such as robots and tasks multiply. As previously stated, this article solves the issue using a fuzzy‐based optimum path and reverse auction‐based methods. The detailed simulation results indicate that the suggested methods can solve task allocation with the lowest path cost. A comparative study is conducted between the suggested algorithm and two existing commonly used techniques, the auction‐based and the Hungarian algorithms. Finally, the suggested method was run in real‐time on a TurtleBot2 robot. The findings show the suggested algorithm's efficiency and simplicity of implementation.
Minimum spanning tree‐based cluster analysis: A new algorithm for determining inconsistent edges
Authors: Şaar Fadi , Topcu Ahmet E. 
Published: November 2021

AbstractIn recent years, graph‐based data clustering algorithms have become popular as they perform connectivity‐based rather than centroid‐based partitioning. Methods related to minimum spanning tree (MST)‐based data clustering are types of graph‐based algorithms that can recognize arbitrary shapes of clusters by eliminating inconsistent edges from MST graphs. In all MST‐based data clustering algorithms, definition of inconsistent edges is the main problem that needs to be addressed. The longest edges in MST graphs are considered as inconsistent edges under ideal conditions. Nevertheless, outliers often exist in real‐world tasks, which makes the longest edges inaccurate cluster separation indicators. In this paper, we propose a new data clustering algorithm using MST and a critical distance method. The proposed algorithm solves the main issue of MST‐based data clustering, namely identifying and removing inconsistent edges to obtain clusters even in the event that the dataset contains some outliers. It begins by constructing the MST over a given weighted graph based on Euclidean distance and then splits up the graph into clusters by eliminating inconsistent edges using critical distance as a threshold. Integration of the advantages of both MST and critical distance methodology to obtain optimal clusters is the main contribution of this work. The conducted experimental analysis and results using different datasets prove that our proposed clustering algorithm yields better overall performance compared with the most common data clustering algorithms. Taking the Liver and Tumor datasets as an example, the proposed algorithm outperforms all other clustering algorithms with clustering accuracy equal to 0.579 and 0.660, respectively.
How Divalent Cations Interact with the Internal Channel Site of Guanine Quadruplexes
Authors: Zaccaria Francesco , van der Lubbe Stephanie C. C. , Nieuwland Celine , Hamlin Trevor A. , Fonseca Guerra Célia 
Published: November 2021

AbstractThe front cover artwork is provided by the TheoCheM group of the Vrije Universiteit Amsterdam. The image shows that guanine quadruplexes have a stronger binding affinity for divalent cations than monovalent cations. Read the full text of the Article at 10.1002/cphc.202100529.
Natriuresis‐guided therapy in acute heart failure: rationale and design of the Pragmatic Urinary Sodium‐based treatment algoritHm in Acute Heart Failure (PUSH‐AHF) trial
Authors: ter Maaten Jozine M. , Beldhuis Iris E. , van der Meer Peter , Krikken Jan A. , Coster Jenifer E. , Nieuwland Wybe , van Veldhuisen Dirk J. , Voors Adriaan A. , Damman Kevin 
Published: November 2021

AimsInsufficient diuretic response frequently occurs in patients admitted for acute heart failure (HF) and is associated with worse clinical outcomes. Recent studies have shown that measuring natriuresis early after hospital admission could reliably identify patients with a poor diuretic response during hospitalization who might require enhanced diuretic treatment. This study will test the hypothesis that natriuresis‐guided therapy in patients with acute HF improves natriuresis and clinical outcomes.MethodsThe Pragmatic Urinary Sodium‐based treatment algoritHm in Acute Heart Failure (PUSH‐AHF) is a pragmatic, single‐centre, randomized, controlled, open‐label study, aiming to recruit 310 acute HF patients requiring treatment with intravenous loop diuretics. Patients will be randomized to natriuresis‐guided therapy or standard of care. Natriuresis will be determined at set time points after initiation of intravenous loop diuretics, and treatment will be adjusted based on the urinary sodium levels in the natriuresis‐guided group using a pre‐specified stepwise approach of increasing doses of loop diuretics and the initiation of combination diuretic therapy. The co‐primary endpoint is 24‐h urinary sodium excretion after start of loop diuretic therapy and a combined endpoint of all‐cause mortality or first HF rehospitalization at 6 months. Secondary endpoints include 48‐ and 72‐h sodium excretion, length of hospital stay, and percentage change in N‐terminal pro brain natriuretic peptide at 48 and 72 h.ConclusionThe PUSH‐AHF study will investigate whether natriuresis‐guided therapy, using a pre‐specified stepwise diuretic treatment approach, improves natriuresis and clinical outcomes in patients with acute HF.
Impact of Cooling Profile on Refined Palm Oil Crystallization: Microscopic and Small and Wide‐Angle X‐Ray Scattering Investigations
Authors: Sainlaud Chloé , Taché Olivier , Testard Fabienne , Saiter Jean‐Marc , Bohin Maxime C. , Coquerel Gérard 
Published: November 2021

AbstractAmong the different possible strategies, thermal control is a major lever to control fat structure (i.e., triacylglycerols (TAGs) molecules organization and crystals morphology). In this article, the impact of thermal treatments on TAGs packing tendency contained in refined palm oil (RPO) is determined. Three cooling profiles are considered: slow, intermediate, and fast. Slow cooling induces the formation of β’ polymorphic form in sequence as 2Lβ’ then 3Lβ’ configurations. RPO rapidly cooled first crystallizes in α form before turning into the 2Lβ’ structure. At intermediate cooling profile, 2Lβ’ and 3Lβ’ are observed and another original phase ϕ is formed around 0°C. This phase has similarities with the sub‐α phase observed in cocoa butter which corresponds to a β’ subcell and presents the capacity of adapting its composition during cooling, leading to an increase of its interplanar distances by decreasing temperature.Practical applications: In case of fats in food products, suitable cooling profile is a compromise between rheological properties of final product (thus, sensorial properties) and relative stability during storage. In this article, three different cooling profiles applied to RPO, leading to various crystal lattices are studied. These lead to systems with varying sensory properties and stability.
Fabrication of a Simple and Cheap Screen‐printed Silver/Silver Chloride (Ag/AgCl) Quasi‐reference Electrode
Authors: Ferreira Oliveira Ana Elisa , Pereira Arnaldo César , Campos de Resende Mayra Asevedo , Ferreira Lucas Franco 
Published: November 2021

AbstractIn this work, a silver/silver chloride ink is fabricated using two steps. First the silver ink is prepare using silver, nail polish and acetone. Then the silver ink is painted in a paper substrate and a silver chloride layer is deposited using a bleach solution. The result is the silver/silver chloride conductive ink. The silver ink is cheap ($2.49/g), well‐dispersive and very easy to fabricate. The materials were characterized by SEM and XRD. The Ag ink showed the formation of a continuous network throughout the silver ink film with fewer agglomeration. The effective chlorination process was also observed in the Ag/AgCl characterization. Since the Ag/AgCl substrate will be used as a quasi‐reference electrode, it is important to investigate the electrical properties. The Ag ink showed an average ohmic resistance of 2.27 Ω. The addition of the AgCl layer decreases the conductivity, as expected. In summary, the Ag/Ag/Cl ink developed is simple, well‐dispersed, cheap and with good conductivity. Therefore, it can be used as a conductive ink in the fabrication of quasi‐reference electrodes.
A survey of applied machine learning techniques for optical orthogonal frequency division multiplexing based networks
Authors: Mrabet Hichem , Giacoumidis Elias , Dayoub Iyad , Belghith Aymen 
Published: November 2021

AbstractIn this survey, we analyze the newest machine learning (ML) techniques applied in modern optical orthogonal frequency division multiplexing (O‐OFDM) systems for access, core networks, and multi‐channel transmission. From rudimentary to more advanced approaches, ML is proven to be a gold standard technique for signal quality improvement when low transmitter modulation extinction ratio dominates in coherent O‐OFDM, and when stochastic‐induced nonlinearities are present such as parametric noise amplification in long‐haul transmission and the interplay between polarization‐mode dispersion and the Kerr‐induced nonlinearity. In addition, ML algorithms can effectively tackle determinist nonlinear distortions in O‐OFDM networks, as well as inter‐subcarrier nonlinear effects (ie, inter‐subcarrier four‐wave mixing and cross‐phase modulation). In essence, ML techniques could be potentially beneficial for any multi‐carrier approach (eg, filter bank modulation). The survey illustrates an extensive ML taxonomy for O‐OFDM based networks, covering supervised, reinforcement learning and unsupervised ML categories. The transmission performance of various ML‐assisted O‐OFDM systems is presented taking into account the ML computational complexity toward real‐time implementation. We also highlight the strict operating conditions for such systems under which a ML algorithm should perform classification, regression or clustering. Finally, the survey opens research issues and future directions toward ML implementation in radio‐over‐fiber (RoF) and 5G new radio (NR) systems.
The U.S. Inland Creel and Angler Survey Catalog (CreelCat): Development, Applications, and Opportunities
Authors: Lynch Abigail J , Sievert Nicholas A , Embke Holly S , Robertson Ashley M , Myers Bonnie J E , Allen Micheal S , Feiner Zachary S , Hoogakker Frederick , Knoche Scott , Krogman Rebecca M , Midway Stephen R , Nieman Chelsey L , Paukert Craig P , Pope Kevin L , Rogers Mark W , Wszola Lyndsie S , Beard T Douglas 
Published: November 2021

Abstract
Inland recreational fishing, defined as primarily leisure-driven fishing in freshwaters, is a popular pastime in the USA. State natural resource agencies endeavor to provide high-quality and sustainable fishing opportunities for anglers. Managers often use creel and other angler survey data to inform state- and waterbody-level management efforts. Despite the broad implementation of angler surveys and their importance to fisheries management at state scales, regional and national coordination among these activities is minimal, limiting data applicability for larger-scale management practices and research. Here, we introduce the U.S. Inland Creel and Angler Survey Catalog (CreelCat), a first-of-its-kind, publicly available national database of angler survey data that establishes a baseline of national inland recreational fishing metrics. We highlight research and management applications to help support sustainable inland recreational fishing practices, consider cautions, and make recommendations for implementation.
Safety evaluation of Lactococcus lactis IDCC 2301 isolated from homemade cheese
Authors: Kim Taeok , Mondal Shakti Chandra , Jeong Chae‐Rim , Kim So‐Rim , Ban O‐Hyun , Jung Young Hoon , Yang Jungwoo , Kim Soo‐Jung 
Published: November 2021

AbstractFor applications of microorganisms as probiotics in the food industry, safety evaluation has increasingly become important to ensure the health of consumers. Although people have been using various lactic acid bacteria for different purposes, some studies have reported that certain lactic acid bacteria exhibit properties of virulence and produce toxic compounds. Thus, it is necessary to examine the characteristics associated with lactic acid bacteria that are safe for use as probiotics. This research aimed to assess the safety of Lactococcus lactis IDCC 2301 isolated from homemade cheese using in vitro and in vivo assays, including antibiotic resistance, hemolytic activity, toxin production, infectivity, and metabolic activity in immune‐compromised animal species. The results demonstrated that the strain was susceptible to nine antibiotics suggested by the European Food Safety Authority (EFSA). Whole‐genome analysis revealed that L. lactis IDCC 2301 neither has toxigenic genes nor harbors antibiotic resistance. Moreover, L. lactis IDCC 2301 showed neither hemolytic nor β‐glucuronidase activity. Furthermore, none of the D‐lactate and biogenic amines were produced by L. lactis IDCC 2301. Finally, it was demonstrated that there was no toxicity and mortality using single‐dose oral toxicity tests in rats. These results indicate that L. lactis IDCC 2301 can be safely used as probiotics for human consumption.
The hedging pressure hypothesis and the risk premium in the soybean reverse crush spread
Authors: Li Ziran , Hayes Dermot J. 
Published: November 2021

AbstractThis article formalizes Keynes's hypothesis that the need to attract speculative capital to match hedgers' trades will create a difference between the futures and expected maturity price. We expand this analysis to the soybean complex where we have speculators and hedgers in soybeans, soybean meal, and soybean oil. We focus on the crush spread because it is unlikely that hedgers will want to make simultaneous trades on the opposite side of soybean crushers in all three markets. We find strong evidence of a positive return to speculators who provide this liquidity.
Do oil shocks impact stock liquidity?
Authors: Zhang Qin , Wong Jin Boon 
Published: November 2021

AbstractThis paper investigates the impact of oil shocks on the stock liquidity of US listed companies. Using high frequency tick‐by‐tick intraday data and an innovative method to derive oil demand and supply shocks, we find evidence that differentiated oil shocks have distinctive influence on stock liquidity. Specifically, oil shocks driven by demand lower stock liquidity, whereas oil supply shocks have the opposite effect. Generally large corporations are more affected by oil demand and supply shocks. Further analysis reveals that oil, oil‐related, oil‐user and the broad market categories are most affected by oil shocks, but the effects on oil‐substitutes are minimum.
Treatment outcomes and survival following definitive (chemo)radiotherapy in HPV‐positive oropharynx cancer: Large‐scale comparison of DAHANCA vs PMH cohorts
Authors: Lassen Pernille , Huang Shao Hui , Su Jie , Waldron John , Andersen Maria , Primdahl Hanne , Johansen Jørgen , Kristensen Claus Andrup , Andersen Elo , Eriksen Jesper Grau , Hansen Christian Rønn , Alsner Jan , Lilja‐Fisher Jacob , Bratman Scott V. , Ringash Jolie , Kim John , Hope Andrew , Spreafico Anna , de Almeida John , Xu Wei , O'Sullivan Brian , Overgaard Jens 
Published: November 2021

AbstractWe compare outcomes in two large‐scale contemporaneously treated HPV‐positive (HPV+) oropharynx cancer (OPC) cohorts treated with definitive radiotherapy/chemoradiotherapy (RT/CRT). p16‐confirmed HPV+ OPC treated between 2007 and 2015 at PMH and DAHANCA were identified. Locoregional failure (LRF), distant metastasis (DM), and overall survival (OS) were compared. Multivariable analysis (MVA) calculated adjusted‐hazard‐ratio (aHR) with 95% confidence interval (95% CI), adjusting for cohort, age, gender, performance status, smoking pack‐years, T‐category and N‐category and chemotherapy. Compared to PMH (n = 701), DAHANCA (n = 1174) contained lower TNM‐8T‐categories (T1‐T2: 77% vs 56%), N‐categories (N0‐N1: 77% vs 67%) and stages (stage I: 63% vs 44% (all P < .001). PMH used standard‐fractionation CRT in 69% (481) while 31% (220) received hypofractionated or moderately accelerated RT‐alone. All DAHANCA patients were treated with moderately accelerated RT; 96% (1129) received nimorazole (NIM) and 73% (856) concurrent weekly cisplatin. DAHANCA had shorter overall‐treatment‐time (P < .001), lower gross tumor (66‐68 vs 70 Gy) and elective neck (50 vs 56 Gy) doses. Median follow‐up was 4.8 years. DAHANCA had higher 5‐year LRF (13% vs 7%, aHR = 0.47 [0.34‐0.67]), comparable DM (7% vs 12%, aHR = 1.32 [0.95‐1.82]), but better OS (85% vs 80%, aHR = 1.30 [1.01‐1.68]). CRT patients had a lower risk of LRF (aHR 0.56 [0.39‐0.82]), DM (aHR 0.70 [0.50‐1.00]) and death (aHR 0.39 [0.29‐0.52]) vs RT‐alone. We observed exemplary outcomes for two large‐scale trans‐Atlantic HPV+ OPC cohorts treated in a similar manner. Concurrent chemotherapy was a strong, independent prognostic factor for all endpoints. Our findings underscore the need for a very careful approach to de‐intensification of treatment for this disease.
Three‐dimensional cell‐laden collagen scaffolds: From biochemistry to bone bioengineering
Authors: Nogueira Lucas Fabricio Bahia , Maniglia Bianca C. , Buchet Rene , Millán José Luis , Ciancaglini Pietro , Bottini Massimo , Ramos Ana Paula 
Published: November 2021

AbstractThe bones can be viewed as both an organ and a material. As an organ, the bones give structure to the body, facilitate skeletal movement, and provide protection to internal organs. As a material, the bones consist of a hybrid organic/inorganic three‐dimensional (3D) matrix, composed mainly of collagen, noncollagenous proteins, and a calcium phosphate mineral phase, which is formed and regulated by the orchestrated action of a complex array of cells including chondrocytes, osteoblasts, osteocytes, and osteoclasts. The interactions between cells, proteins, and minerals are essential for the bone functions under physiological loading conditions, trauma, and fractures. The organization of the bone's organic and inorganic phases stands out for its mechanical and biological properties and has inspired materials research. The objective of this review is to fill the gaps between the physical and biological characteristics that must be achieved to fabricate scaffolds for bone tissue engineering with enhanced performance. We describe the organization of bone tissue highlighting the characteristics that have inspired the development of 3D cell‐laden collagenous scaffolds aimed at replicating the mechanical and biological properties of bone after implantation. The role of noncollagenous macromolecules in the organization of the collagenous matrix and mineralization ability of entrapped cells has also been reviewed. Understanding the modulation of cell activity by the extracellular matrix will ultimately help to improve the biological performance of 3D cell‐laden collagenous scaffolds used for bone regeneration and repair as well as for in vitro studies aimed at unravelling physiological and pathological processes occurring in the bone.