bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fission yeast TOR complex 1 phosphorylates Psk1 through an evolutionarily conserved interaction mediated by the TOS motif
Authors: Morozumi Yuichi , Hishinuma Ai , Furusawa Suguru , Sofyantoro Fajar , Tatebe Hisashi , Shiozaki Kazuhiro 
Published: September 2021

ABSTRACT
TOR complex 1 (TORC1) is a multi-subunit protein kinase complex that controls cellular growth in response to environmental cues. The regulatory subunits of mammalian TORC1 (mTORC1) include RAPTOR (also known as RPTOR), which recruits mTORC1 substrates, such as S6K1 (also known as RPS6KB1) and 4EBP1 (EIF4EBP1), by interacting with their TOR signaling (TOS) motif. Despite the evolutionary conservation of TORC1, no TOS motif has been described in lower eukaryotes. In the present study, we show that the fission yeast S6 kinase Psk1 contains a TOS motif that interacts with Mip1, a RAPTOR ortholog. The TOS motif in Psk1 resembles those in mammals, including the conserved phenylalanine and aspartic acid residues essential for the Mip1 interaction and TORC1-dependent phosphorylation of Psk1. The binding of the TOS motif to Mip1 is dependent on Mip1 Tyr-533, whose equivalent in RAPTOR is known to interact with the TOS motif in their co-crystals. Furthermore, we utilized the mip1-Y533A mutation to screen the known TORC1 substrates in fission yeast and successfully identified Atg13 as a novel TOS-motif-containing substrate. These results strongly suggest that the TOS motif represents an evolutionarily conserved mechanism of the substrate recognition by TORC1.
A Video-Enhanced, Electronic Modality for Preparticipation Examination of Young Athletes
Authors: Parizher Gary , Phelan Dermot M. , Ayers Colby , Goodwin Russell , Levine Benjamin D. 
Published: September 2021

Abstract
We developed a video-enhanced preparticipation evaluation symptom questionnaire (the V-PPE), intended to help screen athletes for heart disease. We now report results of a pilot quality improvement study evaluating V-PPE's performance. In a prospective before-and-after study, approximately 5700 high-school athletes were prompted to voluntarily fill out the V-PPE questionnaire. We compared symptom frequencies on standard PPE to those on V-PPE. Of 5700 athletes, 46 (0.8%), 117 (2.0%), 33 (0.6%), and 101 (1.8%) reported syncope, angina, palpitations, and dyspnea, respectively on routine screening. Four hundred and ninety-two (8.6%) voluntarily filled out the V-PPE. Athletes were more likely to report palpitations on V-PPE than PPE, but not angina, dyspnea, syncope, or at least one symptom. Symptom frequencies on electronic PPE questionnaires are lower than recent reports suggest. Embedded videos can alter screening yield. More research is necessary to evaluate the predictive value of the V-PPE for clinically relevant cardiac pathology.
Disparities and Inequities in Youth Sports
Authors: Kuhn Andrew W. , Grusky Alan Z. , Cash Carsen R. , Churchwell Andre L. , Diamond Alex B. 
Published: September 2021

Abstract
Participation in youth sports can have a positive, lasting impact on a child’s general health and physical well-being. Unfortunately, some youth populations are unable to participate and/or reap the benefits of sports because of existing inequities. Youth from lower socioeconomic status and ethnic minority children have been found to participate in sports less. These disparities are unfortunately pervasive and likely the result of multiple barriers, including financial and time constraints, limited resources and the inability to access facilities both in and out of school, and lack of familial support. There also exist inequities with regard to sports injury management, including knowledge, access to athletic trainers, and care. This article provides a review of the numerous disparities and inequities in youth sports. Compiling and understanding these data may help develop a framework to make youth sports more equitable and beneficial for all.
Prior elicitation of the efficacy and tolerability of Methotrexate and Mycophenolate Mofetil in Juvenile Localised Scleroderma
Authors: Desai Yasin , Jaki Thomas , Beresford Michael W , Burnett Thomas , Eleftheriou Despina , Jacobe Heidi , Leone Valentina , Li Suzanne , Mozgunov Pavel , Ramanan Athimalaipet V , Torok Kathryn S , Anderson Marina E , Anton Jordi , Avcin Tadej , Felton Jessie , Foeldvari Ivan , Laguda Bisola , McErlane Flora , Shaw Lindsay , Zulian Francesco , Pain Clare E 
Published: September 2021

Background Evidence is lacking for safe and effective treatments for juvenile localised scleroderma (JLS). Methotrexate (MTX) is commonly used first line and mycophenolate mofetil (MMF) second line, despite a limited evidence base. A head to head trial of these two medications would provide data on relative efficacy and tolerability. However, a frequentist approach is difficult to deliver in JLS, because of the numbers needed to sufficiently power a trial. A Bayesian approach could be considered. Methods An international consensus meeting was convened including an elicitation exercise where opinion was sought on the relative efficacy and tolerability of MTX compared to MMF to produce prior distributions for a future Bayesian trial. Secondary aims were to achieve consensus agreement on critical aspects of a future trial. Results An international group of 12 clinical experts participated. Opinion suggested superior efficacy and tolerability of MMF compared to MTX; where most likely value of efficacy of MMF was 0.70 (95% confidence interval (CI) 0.34-0.90) and of MTX was 0.68 (95% CI 0.41-0.8). The most likely value of tolerability of MMF was 0.77 (95% CI 0.3-0.94) and of MTX was 0.62 (95% CI 0.32-0.84). The wider CI for MMF highlights that experts were less sure about relative efficacy and tolerability of MMF compared to MTX. Despite using a Bayesian approach, power calculations still produced a total sample size of 240 participants, reflecting the uncertainty amongst experts about the performance of MMF. Conclusions Key factors have been defined regarding the design of a future Bayesian approach clinical trial including elicitation of prior opinion of the efficacy and tolerability of MTX and MMF in JLS. Combining further efficacy data on MTX and MMF with prior opinion could potentially reduce the pre-trial uncertainty so that, when combined with smaller trial sample sizes a compelling evidence base is available.
Improving the support for XML dynamic updates using a hybridization labeling scheme (ORD-GAP)
Authors: Haw Su-Cheng , Amin Aisyah , Wong Chee-Onn , Subramaniam Samini 
Published: September 2021

Background: As the standard for the exchange of data over the World Wide Web, it is important to ensure that the eXtensible Markup Language (XML) database is capable of supporting not only efficient query processing but also capable of enduring frequent data update operations over the dynamic changes of Web content. Most of the existing XML annotation is based on a labeling scheme to identify each hierarchical position of the XML nodes. This computation is costly as any updates will cause the whole XML tree to be re-labelled. This impact can be observed on large datasets. Therefore, a robust labeling scheme that avoids re-labeling is crucial. Method: Here, we present ORD-GAP (named after Order Gap), a robust and persistent XML labeling scheme that supports dynamic updates. ORD-GAP assigns unique identifiers with gaps in-between XML nodes, which could easily identify the level, Parent-Child (P-C), Ancestor-Descendant (A-D) and sibling relationship. ORD-GAP adopts the OrdPath labeling scheme for any future insertion. Results: We demonstrate that ORD-GAP is robust enough for dynamic updates, and have implemented it in three use cases: (i) left-most, (ii) in-between and (iii) right-most insertion. Experimental evaluations on DBLP dataset demonstrated that ORD-GAP outperformed existing approaches such as ORDPath and ME Labeling concerning database storage size, data loading time and query retrieval. On average, ORD-GAP has the best storing and query retrieval time. Conclusion: The main contributions of this paper are: (i) A robust labeling scheme named ORD-GAP that assigns certain gap between each node to support future insertion, and (ii) An efficient mapping scheme, which built upon ORD-GAP labeling scheme to transform XML into RDB effectively.
Exploratory graph analysis of the network data of the Ethereum blockchain
Authors: Yap Timothy Tzen Vun , Ho Ting Fong , Ng Hu , Goh Vik Tor 
Published: September 2021

Background: This research uses exploratory graph analysis to analyze the transaction data of the Ethereum network. This is achieved through network visualization and mathematical and statistical modelling of the network data. Methods: The dataset used in this study was extracted from the Ethereum in the BigQuery public dataset, specifically selected transactions in July 2019. The transactions were firstly modelled as network graphs and then visualized using the Kamada-Kawai and force-directed graphs layouts. Further modelling was explored with classical random graph and network block, with emphasis on network cohesion, hierarchical clustering and community membership. Results: Looking at the network visualization and hierarchical clustering of the data, the network shows 170 clusters, the largest having 135 members. Through random graph modelling the optimum number of clusters is shown to be 95. Referring to the generated dendrograms, notable large transactions center around the DRINK token, the Maximine Exchange, the Upbit2 Exchange and the IDEX Exchange, identified through public disclosure of their Ethereum addresses. The network graphs tend to go towards the DRINK smart contract and the Maximine Exchange, indicating deposit actions, while it is the opposite for the IDEX Exchange. Further analysis also shows a different number of communities than the expected number. Falling short of the expected 170 clusters, the model is not able to capture additional mechanism that may be present at the density and social interaction distribution level of the network. On the other hand, network block modelling shows only four major clusters out of the 170 expected clusters, an indication that the model is not able to capture the network sufficiently. Conclusions: The study was able to capture and model the interconnectedness of the system with its notion of elements, in this case, the transactions on the network.
Assessing the generalisability of a multicentre qualitative dementia research: the experience and challenges faced by the MinD project in Europe
Authors: Lim Jennifer N.W. , Niedderer Kristina , Tournier Isabelle , Almeida Rosa , Harrison Dew , Holthoff-Detto Vjera , Ludden Geke , van Rompay Thomas , van der Voort Mascha , Galansinska Aleksandra , Smith Tina , Lasada Raquel L. , Bueno Yolanda A. , Druschke Diana , Ziebuhr Berit , Zanasi Michele 
Published: September 2021

Background: Generalisation of findings is an important aspect of research and essential for evidence-based practice. While generalisation is common in quantitative research, there is a lack of generalisability in qualitative research. This paper presents the experience and challenges faced by the Designing for People with Dementia (MinD) project in meeting the requirements to strengthen the generalisation of findings on the lived experience of people living with dementia and their engagement to co-create designs to empower their everyday living. Methods: Polit and Beck (2010)’s strategies to generalise qualitative findings were applied: (1) replication in sampling; (2) replication of studies; (3) meta-synthesis of findings; (4) reflexivity and conceptualization; (5) immersion with the data; and (6) thick description.Results: While it is possible to increase the generabilisabilty of qualitative evidence through the replication of the sampling to attain a large, heterogeneous sample in different and multiple contexts and environments; implementation of sound and robust research; conducting in-depth analysis and interpretation collaboratively for emergent themes; and meeting the thick description requirement, there are challenges that the project team faced in implementing some of the Polit and Beck’s strategies because of the condition, namely dementia, that our participants are having. Other challenges faced were: the language and culturaldiversity in the team; diverse work and organisational procedures; and the inter-disciplinary differences relating to the methods of enquiry, approaches and techniques to conduct research. These challenges will need to be identified and addressed at the start of the project with a strong leadership to ensure a seamless journey to complete the project successfully.Trust between the researchers and participants, and time to build this trust are critical to recruitment and participation in the study; these factors are of utmost important in research involving participants with condition such as dementia.
Leviathan Inc. and Corporate Environmental Engagement
Authors: Hsu Po-Hsuan , Liang Hao , Matos Pedro 
Published: September 2021

In a 2010 special report, The Economist magazine termed the resurgence of state-owned, publicly listed enterprises “Leviathan Inc.” and criticized the poor governance and low efficiency of these firms. We compile a new comprehensive data set of state ownership of publicly listed firms in 44 countries over the period of 2004–2017 and show that state-owned enterprises are more responsive to environmental issues. The effect is more pronounced in economies lacking energy security and strong environmental regulation, and among firms with more local operations and higher domestic government ownership. We find a similar effect on corporate social engagement but not on governance quality. These results suggest a different role for “Leviathan Inc.,” especially in dealing with environmental externalities. This paper was accepted by Colin Mayer, Special Section of Management Science on Business and Climate Change. Funding: H. Liang acknowledges the DBS Sustainability Fellowship from Singapore Management University. P.-H. Hsu acknowledges the fellowship from the Batten Institute of Darden School of Business of the University of Virginia and the financial support from the E.SUN Academic Award and Ministry of Science and Technology and Ministry of Education in Taiwan [Grants MOST108-2410-H-007-099-MY2, MOST109-2628-H-007-001-MY4, MOST109-2634-F-002-045, MOE109J0321Q2, and MOE109L900202]. P. Matos acknowledges financial support from the Richard A. Mayo Center for Asset Management at the University of Virginia's Darden School of Business. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2021.4064 .
Short-pulse broadband stimulated Raman scattering in carbon disulfide via resonance cascading
Authors: Li Shuang , Wang Ying , Liu Xiaofeng , Sun Chenglin , Fang Wenhui , Men Zhiwei 
Published: September 2021

Cascaded stimulated Raman scattering (SRS) of carbon disulfide (

C
S

2

) was investigated by a pulsed Nd:YAG laser with a wavelength of 532 nm. The fourth-order Stokes and second-order anti-Stokes lines were generated when the pump laser energy was about 1.909 mJ in one sample cell (

C

1

) only. However, the same result was obtained in the second sample cell (

C

2

) with a pump energy of 0.883 mJ. At the same time, the fifth-order Stokes line was produced in

C

2

when the pump energy increased to 1.208 mJ, and the coherent radiation wavelength ranged from 498 to 644 nm. The result was attributed to the resonance enhancement effect, where the frequency difference between the pump laser and the Stokes light emitted from the working medium (

C
S

2

) self-matched with the vibrational energy level of

C

=

S

, which resulted in the generation of the cascaded broadband SRS. The anti-Stokes SRS was attributed to four-wave mixing. Simultaneously, the pulse durations of the Stokes and anti-Stokes were compressed to about 380 ps by SRS and laser-induced breakdown. The resonance effect not only reduced the threshold, but it also generated broadband and short-pulse SRS.
Simultaneous measurement of salinity and temperature using a Sagnac interferometer based on concatenated polarization-maintaining fiber tapers
Authors: Yang Chengkun , Zhang Shengqi , Shi Donglei , Wu Yichang , Cao Zihan , Liu Zhengyong 
Published: September 2021

A Sagnac loop interferometer based on concatenated polarization-maintaining fiber (PMF) tapers is proposed for simultaneous measurement of seawater salinity and temperature. The influences of the distance between the PMF tapers as well as fiber taper diameter on sensor performance have been investigated. Experimental results indicate that the fabricated sensor with a distance of 3 cm between adjacent fiber tapers possesses the salinity and temperature sensitivities of 0.367 nm/% and

−

0.728

n
m

/

∘

C

, respectively, and the taper waist diameter of 20 µm would help to improve salinity sensitivity in comparison with a sensor of 30 µm in diameter. The proposed Sagnac loop interferometer based on concatenated PMF tapers is expected to find potential applications in the measurement of seawater salinity.
Thermally enhanced responsivity in an all-silicon optical power monitor based on defect-mediated absorption
Authors: Huang Qikai , Yu Hui , Zhang Qiang , Li Yan , Chen Weiwei , Wang Yuehai , Yang Jianyi 
Published: September 2021

We demonstrate a high responsivity all-silicon in-line optical power monitor by using the thermal effect to enhance the quantum efficiency of defect-mediated absorption at 1550 nm. The doping compensation technique is utilized to increase the density of lattice defects responsible for the sub-bandgap absorption and suppress the detrimental free carrier absorption. The 200-μm-long device presents a propagation loss as low as 2.9 dB/cm. Its responsivity is enhanced from 12.1 mA/W to 112 mA/W at

−
9

V

bias by heating the optical absorption region. With this device, we build an optical power monitoring system that operates in the sampling mode. The minimal detectable optical power of the system is below

−
22.8

dBm

, while the average power consumption is less than 1 mW at a sampling frequency of 10 Hz. Advantages of this scheme in terms of high responsivity, low insertion loss, and low power consumption lend itself to implement the feedback control of advanced large-scale silicon photonic integrated circuits.
Enhanced performance of a fast GaAs-based terahertz modulator via surface passivation
Authors: He Yulian , Wang Yuansheng , Yang Qinghui , Zhang Huaiwu , Wen Qiye 
Published: September 2021

Surface-modified semiconductors show enormous potential for opto-terahertz (THz) spatial modulation due to their enhanced modulation depth (MD) along with their inherent broad bandwidth. Taking full advantage of the surface modification, a performance-enhanced, all-optical, fast switchable THz modulator was achieved here based on the surface-passivated GaAs wafer. With a decreased surface recombination rate and prolonged carrier lifetime induced by passivation, S-passivated GaAs was demonstrated as a viable candidate to enhance THz modulation performance in MD, especially at low photodoping levels. Despite a degraded modulation rate owing to the longer carrier lifetime, this passivated GaAs modulator simultaneously realizes a fast modulation at a 69-MHz speed and as high an MD as

∼
94
%

in a spectral wideband of 0.2–1.2 THz. The results demonstrated a new strategy to alleviate the tradeoff between high MD and speed in contrast to bare surfaces or heterogeneous films/unusual geometry on semiconductors including Si, Ge, and GaAs.
The impact of access to water supply and sanitation on the prevalence of active trachoma in Ethiopia: A systematic review and meta-analysis
Authors: Abebe Thomas Ayalew , Tucho Gudina Terefe 
Published: September 2021

Background
Trachoma is a worldwide infectious disease causing blindness. Trachoma continued as a public health problem in Ethiopia due to a lack of sanitation and inadequate prevention strategies. This study aimed to identify the impact of water supply and sanitation intervention on preventing active trachoma among children.

Methods
Systematic literature searches were performed from 4 international databases. The search involved articles published from January 1995 up to March 2019. The Cochran Q and I2 statistical tests were used to check heterogeneity among the studies. A random-effect meta-analysis was employed to determine the pooled estimates with a 95% confidence interval (CI). Data analysis was performed using the CMA V.3 and RevMan 5 software program, and the result of the systematic review was reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Findings
Out of 211 studies screened for the analysis, only 29 studies were finally included in this systematic review and meta-analysis. The result revealed factors that are significantly associated with increased odds of active trachoma. Accordingly, households with no access to toilet facilities (odds ratio [OR]: 2.04, 95% CI: 1.75–2.38), no access to improved water (OR: 1.58, 95% CI: 1.27–1.96), and do not practice regular face washing for children (OR: 4.19, 95% CI: 3.02–5.81) have shown increased odds of active trachoma. Besides, the results show a higher prevalence of active trachoma among children who did not wash their faces with soap and frequently.

Conclusions
The study found strong evidence that lack of access to water, sanitation, and hygiene (WASH) was associated with increased prevalence of active trachoma among children. Therefore, a comprehensive and partnership-oriented program is needed to tackle the problem, but further study will be required to strengthen its implementation.