bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do cooperative banks matter for new business creation? Evidence on Italian manufacturing industry
Authors: Agostino Mariarosaria , Errico Lucia , Rondinella Sandro , Trivieri Francesco 
Published: July 2021

AbstractThis work empirically investigates Italian cooperative banks (BCCs) as a driver of new business creation in the Italian provinces over the period 2003–12. The results show that the presence of BCCs positively and significantly affects firms’ entry rates. We also find that the impact of BCCs diffusion on birth rate tends to be stronger for high tech industries during the pre‐crisis years, whilst it appears larger for low‐tech sectors when considering the post‐crisis period. This evidence suggests that BCCs might play a relevant role in financing innovative and risky firms—though, when banks’ risk‐aversion increases, BCCs tend, unsurprisingly, to downsize the financing of riskier projects.
Petrographic study of the pottery of hunter–gatherers from the lower basin of the Colorado river (Argentina) during the Late Holocene
Authors: Borges Vaz Erika , Pereyra Domingorena Lucas 
Published: July 2021

AbstractThis paper presents the first petrographic study of pottery made by hunter–gatherer societies that inhabited the eastern Pampa–Patagonia transition regions (Buenos Aires province, Argentina), between c.1900 and 400 radiocarbon‐years bp. The data show that the potters maintained technical choices during this period as part of a technological tradition. With this common knowledge, local fabric recipes coexisted linked to the regularity of the use of raw materials in accordance with the geology of the research area. Furthermore, the finding of archaeological clay doughs would indicate the in situ production of vessels in the residential contexts of these pre‐Hispanic populations.
Step‐by‐step technique for the endoscopic treatment of ureteric stricture
Authors: Gao Xiaoshuai , Chen Jixiang , Wang Wei , Peng Liao , Di Xingpeng , Xiao Kaiwen , Li Hong , Wei Xin 
Published: July 2021

ObjectiveTo outline our step‐by‐step technique for the endoscopic treatment of ureteric stricture.Materials and MethodsBetween January 2019 and June 2020, 25 patients with ureteric strictures underwent ureteric bypass and were included in this study. The ureteric bypass surgery included three key steps. First, holmium laser endoureterotomy was used to establish a small channel. Then, balloon dilatation was performed to create a large channel. Finally, an Allium stent was inserted.ResultsOver a median follow‐up time of 12 months, the success rate of ureteric bypass surgery was 92.0% (23/25). The median operating time was 78 min. The incidence of pain was 16% (4/25), and the incidence of fever was 4.0% (1/25). The preoperative hydronephrosis volume and urea nitrogen levels decreased significantly after surgery.ConclusionsWe performed ureteric bypass for patients with ureteric strictures. This technique was found to be safe and effective over a short follow‐up time. For patients who are not suitable for surgical reconstruction, the ureteric bypass technique is a good choice.
“Errors were made:” Public attitudes regarding reconciliation and education in Canada
Authors: Wotherspoon Terry , Milne Emily 
Published: July 2021

AbstractThe 2015 release of the final report of the Truth and Reconciliation Commission of Canada accelerated the extensive range of educational activities across Canadian jurisdictions dedicated to updating curricula and supporting Indigenous students. How have these initiatives affected educational practices and more general understandings about Indigenous‐settler relations? Drawing on data from a survey of public perspectives on education and reconciliation conducted in Alberta and Saskatchewan, this paper addresses the question: What are the current public attitudes regarding reconciliation overall and within Alberta and Saskatchewan schools? We explore these perspectives by highlighting two contrasting orientations – one in which reconciliation is accepted as a form of peaceful coexistence within existing settler colonial frameworks and another in which liberal discourses as well as more openly racist stances serve as a form of democratic colonization that further reinforce those frameworks.
Current evidence for the effectiveness of psychosocial interventions for children undergoing medical procedures
Authors: Chrisler Alison J. , Claridge Amy M. , Staab Jennifer , Daniels Sarah R. , Vaden Victoria , McTaggart Danielle 
Published: July 2021

AbstractBackgroundBecause more than three million children are hospitalized every year in the United States, psychosocial and emotional impacts of hospitalization on children cannot be overlooked. As such, a variety of psychosocial support services are offered in pediatric facilities to reduce the negative effects often associated with hospitalization. This review examines current evidence for the effectiveness of common psychosocial interventions for children and youth undergoing medical procedures.MethodsA total of 34 studies that met selection guidelines, as outlined in Section 2, were included and coded based on study characteristics, intervention type, and study outcomes.ResultsFindings from this literature review indicate that most studies examining the efficacy of psychosocial interventions reported at least positive outcomes for children. Although the review highlighted an overall pattern for improved outcomes following psychosocial intervention, there were some differences in outcomes based on type of intervention. In general, procedural support, preparation, and coping strategies were associated with reduced child anxiety/fear and distress. Procedural support was commonly associated with reduced pain, although many types of interventions demonstrated reduction in child pain. Procedural support was associated with improved procedural success.ConclusionsThis systematic review illustrates the benefits of offering psychosocial interventions, such as procedural support, preparation, teaching coping strategies, and medical play, that support children undergoing medical procedures. There is a need for additional studies that examine psychosocial interventions, including studies that examine long‐term outcomes post‐procedure or hospitalization. Furthermore, more studies need to collect cost‐analysis information specific to the use of psychosocial interventions.
Prevalence of sarcopenia after remission of hypercortisolism and its impact on HRQoL
Authors: Martel‐Duguech Luciana , Alonso‐Jimenez Alicia , Bascuñana Helena , Díaz‐Manera Jordi , Llauger Jaume , Nuñez‐Peralta Claudia , Montesinos Paula , Webb Susan M. , Valassi Elena 
Published: July 2021

AbstractBackgroundCushing's syndrome (CS) is associated with skeletal muscle structural and functional impairment which may persist long‐term despite surgical removal of the source of cortisol excess. Prevalence of sarcopenia and its impact on Health‐Related‐Quality of Life (HRQoL) in ‘cured’ CS is not known. There is a need to identify easy biomarkers to help the clinicians recognise patients at elevated risk of suffering sustained muscle function.Patients and MethodsWe studied 36 women with CS in remission, and 36 controls matched for age, body mass index, menopausal status, and level of physical activity. We analysed the skeletal muscle mass using dual‐energy X‐ray absorptiometry, muscle fat fraction using two‐point Dixon magnetic resonance imaging and muscle performance and strength using the following tests: hand grip strength, gait speed, timed up and go and 30‐s chair stand. We assessed HRQoL with the following questionnaires: SarQoL, CushingQoL, SF‐36. We calculated the sarcopenia index (SI; serum creatinine/serum cystatin C × 100).ResultsPrevalence of sarcopenia, according to the European Working Group on Sarcopenia in Older People (EWGSOP), was greater in CS as compared with controls (19% vs. 3%; p < .05). Patients with sarcopenia had a lower SarQoL score than those without sarcopenia (61 ± 17 vs. 75 ± 14; p < .05), and scored worse on the items pain, easy bruising and worries on physical appearance (p < .05 for all comparisons) of the CushingQoL questionnaire. Patients with sarcopenia had poorer physical functioning on SF‐36 than those without sarcopenia (60 ± 23 vs. 85 ± 15; p < .01). SI was lower in patients with sarcopenia than those without (71 ± 3 vs. 77 ± 2; p = .032), and was associated with intramuscular fatty infiltration, worse performance on the 30‐s chair stand test, slower gait speed, and worse muscle weakness‐related HRQoL, as measured using the SarQoL questionnaire (p < .05). The optimised cut‐off value for the SI ratio to diagnose sarcopenia was 72, which yielded a sensitivity of 73% and a specificity of 90%.ConclusionsSarcopenia is common in patients with CS in long‐term remission, and associated with impaired quality of life. The SI is a potential biomarker allowing clinicians to identify patients at high risk of muscle dysfunction.
Fashion Transfer: Dressing 3D Characters from Stylized Fashion Sketches
Authors: Fondevilla Amelie , Rohmer Damien , Hahmann Stefanie , Bousseau Adrien , Cani Marie‐Paule 
Published: July 2021

AbstractFashion design often starts with hand‐drawn, expressive sketches that communicate the essence of a garment over idealized human bodies. We propose an approach to automatically dress virtual characters from such input, previously complemented with user‐annotations. In contrast to prior work requiring users to draw garments with accurate proportions over each virtual character to be dressed, our method follows a style transfer strategy : the information extracted from a single, annotated fashion sketch can be used to inform the synthesis of one to many new garment(s) with similar style, yet different proportions. In particular, we define the style of a loose garment from its silhouette and folds, which we extract from the drawing. Key to our method is our strategy to extract both shape and repetitive patterns of folds from the 2D input. As our results show, each input sketch can be used to dress a variety of characters of different morphologies, from virtual humans to cartoon‐style characters.
The role of interleukin‐1β in the immune response to contact allergens
Authors: Yeung Kelvin , Mraz Veronika , Geisler Carsten , Skov Lone , Bonefeld Charlotte M. 
Published: July 2021

AbstractInterleukin‐1β (IL‐1β) is an important pro‐inflammatory cytokine that has an effect on almost every cell lineage in the body. By blocking IL‐1β and investigating the IL‐1β signaling pathway, several studies have demonstrated a central role of IL‐1β in the response to contact allergens. This review summarizes the current literature regarding the basic immunological mechanisms mediated by IL‐1β in the different phases of allergic contact dermatitis (ACD) and highlights potential IL‐1β‐targeted treatment options, which in the future may be relevant in the treatment of patients with ACD. This review is based primarily on studies using various mouse models and human in vitro studies, since clinical studies on the effect of IL‐1β in ACD are lacking.
RAB14 GTPase is essential for actin‐based asymmetric division during mouse oocyte maturation
Authors: Zou Yuan‐Jing , Shan Meng‐Meng , Wang Hong‐Hui , Pan Zhen‐Nan , Pan Meng‐Hao , Xu Yi , Ju Jia‐Qian , Sun Shao‐Chen 
Published: July 2021

AbstractObjectivesRAB14 is a member of small GTPase RAB family which localizes at the endoplasmic reticulum (ER), Golgi apparatus and endosomal compartments. RAB14 acts as molecular switches that shift between a GDP‐bound inactive state and a GTP‐bound active state and regulates circulation of vesicles between the Golgi and endosomal compartments. In present study, we investigated the roles of RAB14 during oocyte meiotic maturation.Materials and methodsMicroinjection with siRNA and exogenous mRNA for knock down and rescue, and immunofluorescence staining, Western blot and real‐time RT‐PCR were utilized for the study.ResultsOur results showed that RAB14 localized in the cytoplasm and accumulated at the cortex during mouse oocyte maturation, and it was also enriched at the spindle periphery. Depletion of RAB14 did not affect polar body extrusion but caused large polar bodies, indicating the failure of asymmetric division. We found that absence of RAB14 did not affect spindle organization but caused the spindle migration defects, and this might be due to the regulation on cytoplasmic actin assembly via the ROCK‐cofilin signalling pathway. We also found that RAB14 depletion led to aberrant Golgi apparatus distribution. Exogenous Myc‐Rab14 mRNA supplement could significantly rescue these defects caused by Rab14 siRNA injection.ConclusionsTaken together, our results suggest that RAB14 affects ROCK‐cofilin pathway for actin‐based spindle migration and Golgi apparatus distribution during mouse oocyte meiotic maturation.
Capacity reservation and sourcing under exchange‐rate uncertainty
Authors: Gheibi Shahryar , Kazaz Burak , Webster Scott 
Published: July 2021

AbstractWe study a firm's capacity reservation and sourcing decisions under exchange‐rate and demand uncertainty. The firm initially reserves capacity from one domestic and one international supplier in the presence of exchange‐rate and demand uncertainty. After observing exchange rates, the firm determines the amount of capacity to utilize for sourcing under demand uncertainty. The article makes four contributions. First, it identifies the set of optimal capacity reservation policies for sourcing activities: One onshore, two offshore, and two dual sourcing policies. The first dual sourcing policy is a defensive action where the firm rations limited capacity between the two sources. The second dual sourcing policy is an opportunistic approach as it features excess capacity investment in order to benefit from currency fluctuations. The analysis shows how the optimal sourcing policy changes with increasing degrees of exchange‐rate volatility. Second, while earlier publications classify cost as an order qualifier, we find that characterization of a dominant sourcing strategy is more nuanced under exchange rate uncertainty. In particular, a buyer might not reserve capacity at a supplier who has a lower (expected) cost and choose to work only with a supplier who has a higher unit expected cost. Third, the article shows that risk aversion reduces the likelihood of single sourcing, specifically offshore sourcing, and increases the likelihood of dual sourcing. Fourth, the study demonstrates that financial hedging can eliminate the negative consequences of risk aversion and make the policy findings more pronounced.
Live visualization of a functional RET‐EGFP chimeric receptor in homozygous knock‐in mice
Authors: Sunardi Mukhamad , Ito Keisuke , Enomoto Hideki 
Published: July 2021

AbstractThe GDNF Family Ligands (GFLs) regulate neural development and kidney organogenesis by activating the RET receptor tyrosine kinase. Many RET‐dependent developmental processes involve long‐distance cell‐cell communications or cell polarity, which includes cell migration and axon guidance. This suggests that spatiotemporally regulated subcellular localization of RET protein and appropriate propagation of RET signaling in cells are essential for the physiological function of the GFLs. Little is known, however, about the dynamics of RET protein in cells. Addressing this issue requires development of a system that allows visualization of RET in living cells. In this study, we report generation of a novel knock‐in mouse line in which the RET‐EGFP chimeric receptor is expressed under the Ret promoter. Unlike Ret‐deficient mice that die after birth due to the absence of the enteric nervous system (ENS) and kidneys, RetRET‐EGFP/RET‐EGFP mice were viable and grew to adulthood with no overt abnormality, which indicated that RET‐EGFP exerts function comparable to RET. In neurons and ENS progenitors, RET‐EGFP signals were detected both on the cell membrane and in the cytoplasm, the latter of which appeared as a punctate pattern. Time‐lapse imaging of cultured neural cells and embryos revealed active transport of RET‐EGFP puncta in neuronal axons and cell bodies. Immunohistochemical analyses detected RET‐EGFP signals in early and recycling endosomes, indicating that RET‐EGFP is trafficked via the endocytic pathway. RetRET‐EGFP/RET‐EGFP mice enable visualization of functional RET protein in vivo for the first time and provide a unique platform to examine the dynamics and physiology of RET trafficking.
SARS‐CoV‐2 infection as a trigger of humoral response against apolipoprotein A‐1
Authors: Pagano Sabrina , Yerly Sabine , Meyer Benjamin , Juillard Catherine , Suh Noémie , Le Terrier Christophe , Daguer Jean‐Pierre , Farrera‐Soler Lluc , Barluenga Sofia , Piumatti Giovanni , Hartley Oliver , Lemaitre Barbara , Eberhardt Christiane S. , Siegrist Claire‐Anne , Eckerle Isabella , Stringhini Silvia , Guessous Idris , Kaiser Laurent , Pugin Jerome , Winssinger Nicolas , Vuilleumier Nicolas 
Published: July 2021

AbstractBackgroundUnravelling autoimmune targets triggered by SARS‐CoV‐2 infection may provide crucial insights into the physiopathology of the disease and foster the development of potential therapeutic candidate targets and prognostic tools. We aimed at determining (a) the association between anti‐SARS‐CoV‐2 and anti‐apoA‐1 humoral response and (b) the degree of linear homology between SARS‐CoV‐2, apoA‐1 and Toll‐like receptor 2 (TLR2) epitopes.DesignBioinformatics modelling coupled with mimic peptides engineering and competition experiments were used to assess epitopes sequence homologies. Anti‐SARS‐CoV‐2 and anti‐apoA‐1 IgG as well as cytokines were assessed by immunoassays on a case‐control (n = 101), an intensive care unit (ICU; n = 126) and a general population cohort (n = 663) with available samples in the pre and post‐pandemic period.ResultsUsing bioinformatics modelling, linear sequence homologies between apoA‐1, TLR2 and Spike epitopes were identified but without experimental evidence of cross‐reactivity. Overall, anti‐apoA‐1 IgG levels were higher in COVID‐19 patients or anti‐SARS‐CoV‐2 seropositive individuals than in healthy donors or anti‐SARS‐CoV‐2 seronegative individuals (P < .0001). Significant and similar associations were noted between anti‐apoA‐1, anti‐SARS‐CoV‐2 IgG, cytokines and lipid profile. In ICU patients, anti‐SARS‐CoV‐2 and anti‐apoA‐1 seroconversion rates displayed similar 7‐day kinetics, reaching 82% for anti‐apoA‐1 seropositivity. In the general population, SARS‐CoV‐2‐exposed individuals displayed higher anti‐apoA‐1 IgG seropositivity rates than nonexposed ones (34% vs 16.8%; P = .004).ConclusionCOVID‐19 induces a marked humoral response against the major protein of high‐density lipoproteins. As a correlate of poorer prognosis in other clinical settings, such autoimmunity signatures may relate to long‐term COVID‐19 prognosis assessment and warrant further scrutiny in the current COVID‐19 pandemic.
Who gets to play recognitional tag?
Authors: Pinkard Terry 
Published: July 2021

AbstractWith regard to the sociality of agency and the role that second‐person address plays, I propose to contrast and develop (1) a Fichtean‐Darwallian account that seems to tie agency to mutual recognition but tacitly presupposes a more fundamental agency independent of it that enables us to enter the circle of recognition. (2) A Brandomian account that although initially proposing a more robustly social account of agency, ultimately remains entrapped in a game of mirrors. (3) Hegel's own approach recasts the issue by giving up the idea that the sociality of agency can be understood in terms of what I call a game of recognitional tag. Instead, we are inhabiting a practice that involves a social struggle about the very form of this practice, and it is this that Hegel has termed a “struggle for recognition.”
“You” or “We”: The limits of the second‐person perspective
Authors: Honneth Axel 
Published: July 2021

AbstractThe following paper questions the idea behind Stephen Darwall's attempt to ground all moral obligations in a perspective that he calls “second‐personal.” In a first step, I will reconstruct Darwall's argument with the aim of raising doubt over whether the moral norms that supposedly govern interpersonal interactions in fact result from their reference to a “you,” as he claims, rather than from a reference to a collectively implied “we”, as I shall go on to argue (1). Posing this question will then afford me an opportunity to look more closely at Hegel's implicit reservations about Fichte's doctrine of recognition, reservations which I find entirely persuasive (2). In a final step, I will return to Darwall's project. In my view, this project ultimately fails due to its denial of the social, and thus conflictual, character of the moral norms governing participants within the I–you relation (3).
Stabilising role of seed banks and the maintenance of bacterial diversity
Authors: Wisnoski Nathan I. , Lennon Jay T. 
Published: July 2021

AbstractCoexisting species often exhibit negative frequency dependence due to mechanisms that promote population growth and persistence when rare. These stabilising mechanisms can maintain diversity through interspecific niche differences, but also through life‐history strategies like dormancy that buffer populations in fluctuating environments. However, there are few tests demonstrating how seed banks contribute to long‐term community dynamics and the maintenance of diversity. Using a multi‐year, high‐frequency time series of bacterial community data from a north temperate lake, we documented patterns consistent with stabilising coexistence. Bacterial taxa exhibited differential responses to seasonal environmental conditions, while seed bank dynamics helped maintain diversity over less‐favourable winter periods. Strong negative frequency dependence in rare, but metabolically active, taxa suggested a role for biotic interactions in promoting coexistence. Together, our results provide field‐based evidence that niche differences and seed banks contribute to recurring community dynamics and the long‐term maintenance of diversity in nature.
Gut microbiota modulates seizure susceptibility
Authors: Mengoni Francesca , Salari Valentina , Kosenkova Inna , Tsenov Grygoriy , Donadelli Massimo , Malerba Giovanni , Bertini Giuseppe , Del Gallo Federico , Fabene Paolo Francesco 
Published: July 2021

AbstractA bulk of data suggest that the gut microbiota plays a role in a broad range of diseases, including those affecting the central nervous system. Recently, significant differences in the intestinal microbiota of patients with epilepsy, compared to healthy volunteers, have been reported in an observational study. However, an active role of the intestinal microbiota in the pathogenesis of epilepsy, through the so‐called “gut–brain axis,” has yet to be demonstrated. In this study, we evaluated the direct impact of microbiota transplanted from epileptic animals to healthy recipient animals, to clarify whether the microbiota from animals with epilepsy can affect the excitability of the recipients’ brain by lowering seizure thresholds. Our results provide the first evidence that mice who received microbiota from epileptic animals are more prone to develop status epilepticus, compared to recipients of “healthy” microbiota, after a subclinical dose of pilocarpine, indicating a higher susceptibility to seizures. The lower thresholds for seizure activity found in this study support the hypothesis that the microbiota, through the gut–brain axis, is able to affect neuronal excitability in the brain.