bluuebunny/crossref_metadata_2025_split huggingface dataset:
Converting Enzyme Inhibition and the Glomerular Hemodynamic Response to Glycine in Diabetic Rats
Authors: SLOMOWITZ LARRY A. , PETERSON ORJAN W. , THOMSON SCOTT C. 
Published: May 2021

Abstract.
GFR normally increases during glycine infusion. This response is absent in humans and rats with established diabetes mellitus. In diabetic patients, angiotensin-converting enzyme inhibition (ACEI) restores the effect of glycine on GFR. To ascertain the glomerular hemodynamic basis for this effect of ACEI, micropuncture studies were performed in male Wistar-Froemter rats after 5 to 6 wk of insulin-treated streptozotocin diabetes. The determinants of single-nephron GFR (SNGFR) were assessed in each rat before and during glycine infusion. Studies were performed in diabetics, diabetics after 5 d of ACEI (enlapril in the drinking water), and weight-matched controls. Diabetic rats manifest renal hypertrophy and glomerular hyperfiltration but not glomerular capillary hypertension. ACEI reduced glomerular capillary pressure, increased glomerular ultrafiltration coefficient, and did not mitigate hyperfiltration. In controls, glycine increased SNGFR by 30% due to increased nephron plasma flow. In diabetics, glycine had no effect on any determinant of SNGFR. In ACEI-treated diabetics, the SNGFR response to glycine was indistinguishable from nondiabetics, but the effect of glycine was mediated by greater ultrafiltration pressure rather than by greater plasma flow. These findings demonstrate that: (1) The absent response to glycine in established diabetes does not indicate that renal functional reserve is exhausted by hyperfiltration; and (2) ACEI restores the GFR response to glycine in established diabetes, but this response is mediated by increased ultrafiltration pressure rather than by increased nephron plasma flow.
In Vitro Neutrophil Activation by Antibodies to Proteinase 3 and Myeloperoxidase from Patients with Crescentic Glomerulonephritis
Authors: FRANSSEN CASPER F. M. , HUITEMA MINKE G. , KOBOLD ANNEKE C. MULLER , OOST-KORT WIA W. , LIMBURG PIETER C. , TIEBOSCH ANTON , STEGEMAN COEN A. , KALLENBERG CEES G. M. , TERVAERT JAN W. COHEN 
Published: May 2021

Abstract.
Previously, it was found that patients with necrotizing crescentic glomerulonephritis (NCGN) and anti-neutrophil cytoplasmic autoantibodies (ANCA) directed against proteinase 3 (anti-PR3) had a faster deterioration of renal function and more active renal vasculitic lesions than patients with ANCA directed against myeloperoxidase (anti-MPO). Because ANCA-mediated neutrophil activation is thought to play an important role in the pathophysiology of this form of glomerulonephritis, this study was conducted to determine whether anti-PR3 are capable of inducing a more pronounced activation of neutrophils in vitro than anti-MPO. To test this hypothesis, the release of reactive oxygen radicals, as assessed by ferricytochrome c reduction and by dihydrorhodamine 123 oxidation, and the release of granule constituents from healthy donor neutrophils upon stimulation with IgG fractions were measured from 17 anti-PR3- and 14 anti-MPO-positive patients with active NCGN. Patients with anti-PR3 had a higher renal activity index (P < 0.05) compared with patients with anti-MPO. IgG fractions from anti-PR3-positive patients induced more oxygen radical release from tumor necrosis factor-α-primed neutrophils compared with IgG fractions from anti-MPO-positive patients, as assessed by ferricytochrome c reduction (P < 0.05) and dihydrorhodamine 123 oxidation (P < 0.01). In addition, IgG fractions from anti-PR3-positive patients generated more neutrophil degranulation of β-glucuronidase (P < 0.01) than IgG fractions from anti-MPO-positive patients. In conclusion, IgG fractions from anti-PR3-positive patients with NCGN are more potent activators of the respiratory burst and degranulation in vitro than IgG fractions from anti-MPO-positive patients. These observations may be relevant in view of the clinical differences between anti-PR3- and anti-MPO-positive patients with NCGN.
Gene Targeting Approaches to Analyzing Hypertension
Authors: TAKAHASHI NOBUYUKI , SMITHIES OLIVER 
Published: May 2021

Abstract.
Essential hypertension probably results from combinations of small genetic variations that are partly normal variations and may not be appreciably harmful individually. Strategies to identify genes contributing to hypertension are discussed in this review. Gene targeting approaches, especially gene titration, have been used in these studies of hypertension. Gene titration experiments vary the expression of a chosen gene product by generating animals having different numbers of copies of the gene coding for the product. Gene titration is powerful for analyzing quantitative variations seen in common polygenic disorders, such as kidney diseases, diabetes mellitus, and atherosclerosis, as well as hypertension, because it allows tests of causation by determining the effects on a phenotype by changes in expression of the altered gene and because it matches normal quantitative variations more closely than is possible with classic transgenic mice. The use of zero-copy (gene “knockout”) animals generated by gene disruption for studies of qualitative gene effects is also discussed. These various gene targeting experiments help identify genes regulating BP, promote a better understanding of the pathophysiology of the condition, and help identify potential targets for therapies.
INFLUENCE OF CORE VALUES ON EMPLOYEES JOB PERFORMANCE IN THE ROYAL MALAYSIAN NAVY
Authors: Mahmood Nor Asiah , Hamzah Lukman , Singh Ajit , Idris Syed Ahyatuddin Syed , Malik Ikmal Ab. 
Published: May 2021

Purpose of the study: This study is to investigate the influence of Core Values (Honor, Loyalty, Courage, Pride) on the employees’ job performance (JP) in the Royal Malaysian Navy (RMN) at Lumut Naval Base.
Methodology: The data was analyzed using SPSS statistical tools. A descriptive-analytical approach; a simple random sampling of 260 employees was used for analysis. Employed quantitative analysis, data collected through a close and open-ended questionnaire with a 5-point Likert scale. The respondents represented came from the three branches of the RMN consisting of Seaman, Technical, and Supply branch.
Main Findings: The findings were found that courage has a significant influence on the employees’ job performance. The findings also revealed that honour has positively influenced employees’ JP in the RMN
Applications of this study: The implications of this study found that the Honour value is the main factor amongst the other variables. It is the most important component in manipulating the Job Performance of the RMN personnel followed by the Courage value. The other two core values, Pride and Loyalty values did not influence Job Performance as expected. At the beginning of the study, it was expected that the Core Values of the RMN would be the elements that would influence the job performance in the RMN organization since it was launched on 16 August 2011.
Novelty/Originality of this study: Models and theoretical application that can be used for future research could also offer a different perspective of understanding and comprehension as opposed to previous study and research, thus this is one of the Novelties in this study.
ROLE OF TEACHING STYLES ON SELF- REGULATION AMONG THE ADOLESCENTS WITH PHYSICAL DISABILITIES
Authors: Khalid Touseef , Rohail Iffat , Akhtar Andleeb 
Published: May 2021

Purpose of the study: This study examined the role of teaching styles on self-regulation among adolescents with physical disabilities and moderating effects of age on the relationship between teaching styles and self-regulation.
Methodology: 150 students from Islamabad and Rawalpindi divisions were included in this study. Adolescent Self-Regulatory Inventory (Moilanen,2007) and Junior High School Teaching Styles Questionnaire (Chen,2008) was used to assess teaching styles and self-regulation. A purposive-convenient sampling technique was used, and SPSS 22 was used for data analysis.
Main Findings: The results demonstrated that the democratic teaching style was the most perceived teaching style among adolescents with a physical disability. It was found that teaching styles predicts self-regulation significantly with (β = .24, R2 = .05) and p < .001. Democratic teaching style had a significant relationship with long-term self-regulation. Age played a moderator role between teaching style and self-regulation with (β= -.16, R2=.09) and p < .01 among adolescents with a physical disability.
Applications of this study: Results of the study will be helpful in the rehabilitation of this marginalized part of society and helps teachers to understand that how their style could affect the personality development of special students.
Novelty/Originality of this study: There is a need to study the handicapped population, their problems, and opportunities for their rehabilitation, especially in Pakistan. As the needs of students with disabilities are entirely different from regular students, society and teachers need a constructive mindset to solve and eliminate the challenges faced by them.
Quality Improvement: origins, purpose and the future for veterinary practice
Authors: Rooke Freya , Burford John , Freeman Sarah , Mair Tim , Suthers Jo , Brennan Marnie 
Published: May 2021

Introduction
Providing the highest quality veterinary care can often be a delicate balancing act: the client/owner’s wishes, financial parameters and emotional needs have to be considered, whilst also meeting the animal’s clinical needs. But what actually defines quality care? It is a term frequently used in both the human and veterinary healthcare literature, but often has little explanation or definition attached to it. ‘Quality’ in relation to care delivered is not a static concept and will hold different meanings to different individuals within a healthcare service. John Ruskin, a Victorian writer and critic of art and society observed: ‘Quality is never an accident; it is always the result of high intention, sincere effort, intelligent direction and skilful execution’.
Exploring the Relationship Between Familiarity With the ICF and Rehabilitation Counselor Confidence in Facilitating Workplace Accommodations
Authors: Landon Trenton J. , Nay Andrew , Connor Annemarie , Phillips Brian N. , Reyes Antonio R. , Leavitt Jeremy 
Published: May 2021

PurposeThe International Classification of Functioning (ICF) provides a framework for understanding and accommodating disability. This study examined predictors and outcomes of ICF familiarity among rehabilitation counselors.MethodAnalysis of variance and hierarchical regression analysis were used to examine research questions related to ICF familiarity.ResultsRehabilitation counselors with five or fewer years of experience were more familiar with the ICF. Analysis showed familiarity with the ICF positively correlated with greater confidence in recommending work accommodations.ConclusionsData supports use of the ICF in rehabilitation counseling. Emphasizing the ICF in specific courses (e.g., medical aspects of disability, career and vocational development) may support improved practice.
Identifikasi Faktor Pendukung dan Penghambat Aktivitas Apoteker di Media Sosial dalam Menunjang Praktik Kefarmasian
Authors: Naima Fathnin Ulya , Sukorini Anila Impian , Hermansyah Andi 
Published: May 2021

Pendahuluan: Jumlah pengguna media sosial yang besar di Indonesia memberi peluang bagi apoteker untuk memanfaatkan media sosial dalam menunjang praktik kefarmasian. Tujuan: Penelitian ini bertujuan untuk mengidentifikasi faktor-faktor yang mendukung dan menghambat pemanfaatan media sosial oleh apoteker dalam menunjang praktik kefarmasian. Metode: Penelitian ini melibatkan survei secara online kepada apoteker dari berbagai bidang praktik di Jawa Timur. Responden dipilih menggunakan teknik accidental sampling. Pengambilan data dilakukan pada bulan April - Mei 2020. Data kemudian dianalisis menggunakan statistik deskriptif. Hasil: Sejumlah 200 orang apoteker berpartisipasi dalam penelitian ini. Hampir seluruh responden memanfaatkan media sosial untuk memperoleh informasi kefarmasian terkini (99,5%), melakukan komunikasi profesional (98%), dan melakukan promosi kesehatan (91%). Faktor pendukung utama untuk aktif di media sosial adalah kemampuan dalam manajemen waktu (99,5%) dan telah terbiasa untuk menggunakan media sosial (98,5%) sedangkan faktor penghambat terbesar adalah tidak adanya penghargaan termasuk insentif finansial sebagai kompensasi atas aktivitas di media sosial (66,3%). Kesimpulan: Responden dalam penelitian ini telah memanfaatkan media sosial untuk kepentingan praktik profesi. Terdapat faktor pendukung dan penghambat bagi apoteker dalam menggunakan media sosial untuk menunjang praktek. Penghambat utama upaya pemanfaatan media sosial adalah tidak tersedianya insentif finansial.
Pengembangan Aplikasi Digital untuk Manajemen dan Sumber Informasi Hipertensi
Authors: Wahyuni Sri , Khairunnisa Khairunnisa , Harahap Urip 
Published: May 2021

Pendahuluan: Hipertensi adalah suatu penyakit silent killer yang jika tidak terkontrol dapat menyebabkan penyakit jantung, gagal ginjal, stroke, bahkan kematian dini. Namun, penelitian menunjukkan bahwa 32,3% pasien hipertensi tidak rutin minum obat dan 13,3% tidak minum obat. Ketidakpatuhan ini terjadi karena kurangnya pengetahuan pasien. Saat ini, penggunaan ponsel semakin meningkat. Banyak aplikasi kesehatan tersedia, namun tidak memberikan informasi dan edukasi kepada pasien, termasuk edukasi tentang obat. Tujuan: Penelitian ini bertujuan untuk mengembangkan aplikasi digital yang melibatkan apoteker. Aplikasi ini memberikan informasi tentang hipertensi dan penggunaan obatnya serta membantu pasien memanajemen hipertensinya. Metode: Pengembangan aplikasi digital dilakukan melalui 4 tahap yaitu analisis kebutuhan pasien hipertensi yang melibatkan apoteker, desain aplikasi, pengembangan aplikasi dan evaluasi aplikasi. Hasil: Evaluasi aplikasi terdiri dari Alpha test dan Beta test. Alpha test yang dilakukan oleh 2 software developer dan 4 orang apoteker menunjukan bahwa aplikasi digital yang dikembangkan sudah menarik, mudah digunakan dan dapat berfungsi dengan baik. Selanjutnya Beta test yang dilakukan oleh 10 pasien hipertensi menunjukkan bahwa aplikasi digital hipertensi yang dikembangkan sudah memiliki konten yang sesuai dan nyaman digunakan. Kesimpulan: aplikasi digital yang melibatkan apoteker ini sudah siap untuk digunakan dan pasien hipertensi memiliki kesempatan untuk mendapatkan edukasi obat dan hipertensi dari apoteker melalui ponselnya.
Evaluasi Obat Kadaluwarsa, Obat Rusak dan Stok Mati di Puskesmas Wilayah Magelang
Authors: Khairani Revina Nurma , Latifah Elmiawati , Nila Septianingrum Ni Made Ayu 
Published: May 2021

Pendahuluan: Di era Jaminan Kesehatan Nasional, masalah pengelolaan obat di puskesmas masih sering terjadi sehingga perlu dilakukan evaluasi yang berkelanjutan untuk menjamin ketersediaan dan pelayanan obat yang optimal. Tujuan: Penelitian ini bertujuan untuk mengetahui gambaran dan menganalisis terjadinya obat kadaluwarsa, obat rusak dan stok mati, sehingga dapat memberikan rekomendasi kebijakan untuk perbaikan pengelolaan obat. Metode: Penelitian non eksperimental dengan rancangan deskriptif analisis, yang dianalisis secara deskriptif dan kualitatif. Sampel yang digunakan untuk mengevaluasi obat kadaluwarsa dan obat rusak adalah seluruh obat tahun 2019, sedangkan sampel untuk evaluasi stok mati menggunakan kombinasi obat indikator dan obat e-katalog yang paling banyak dikonsumsi pada tahun 2019. Faktor yang mempengaruhi hambatan pengelolaan obat dilakukan observasi dengan wawancara. Hasil: Obat kadaluwarsa di Puskesmas X dan Y sebesar 24% dan 18%, stok mati sebesar 40% dan 20%, tidak ditemukan obat rusak di kedua puskemas. Masalah pengelolaan obat yang dominan terjadi di puskesmas, disebabkan adanya faktor perubahan pola peresepan, tanggal kadaluwarsa yang terlalu pendek dan tidak sesuainya permintaan dengan penerimaan obat dari UPT Instalasi Farmasi. Kesimpulan: Persentase obat kadaluwarsa dan obat stok mati belum sesuai dengan indikator penelitian (0%), sehingga dengan temuan ini perlu dilakukan validasi perencanaan obat yang disesuaikan dengan kebutuhan obat serta peningkatan manajemen pengelolaan obat kadaluwarsa dan penguatan sistem penerimaan obat di puskesmas.
POLA ASUH LONG DISTANCE DALAM PEMBENTUKAN KONSEP DIRI REMAJA (Studi Diskriptif Tentang Pola Asuh Long Distance Dalam Pembentukan Konsep Diri Remaja di SMAN 1 Girimarto, Kabupaten Wonogiri)
Authors: Wulandari Retno Wahyu , Soemanto RB , Kartono Drajat Tri 
Published: May 2021

<p>This study was a descriptive qualitative trying to describe the actual condition of informants. This study aimed to find out the long distance caring pattern in the adolescents in SMA Negeri 1 Girimarto, the establishment of adolescent self-concept in SMA Negeri 1 Girimarto, and the relationship of long distance caring pattern applied to the establishment of adolescent self-concept in SMA Negeri 1 Girimarto. Considering the data obtained, it could be concluded that: caring pattern was divided into two: controlled and free. There were two self-concepts established: dynamic and static. Parent provided reward in the form of material or praise for the achievement the adolescents reached as the form of reward and punishment for the fault or infringement they did. The primary family’s attention contributed to the establishment of adolescent self-concept as well, because the adolescents needed environment as a role model. The adolescents living separately from the parents were accustomed to cope with their problems independently.</p><p> </p><strong>Keywords</strong>: Long distance caring pattern, self-concept, adolescent
EKSKLUSIFITAS SISWA (STUDI FENOMENOLOGI KONSTRUKSI SOSIAL POLA EKSKLUSIFITAS SISWA PADA KELAS UNGGULAN DI SMA MUHAMMADIYAH 1 SRAGEN TAHUN AJARAN 2011/2012)
Authors: Indawatik Rita , Kartono Drajat Tri , Utami Trisni 
Published: May 2021

<p>Superior class (school) is designed to provide adequate learning service to the students with high academic competency. Consequently, this strategy cannot support the attempt of optimizing the rapid development of human resource. On the other hand, the superior class phenomenon also gives rise to exclusive behavior in which the students tend to make group and have intercourse with their superior classmates only. It is that makes the author interested in finding out how the exclusiveness pattern of behavior emerges in the superior students.</p><p>The research strategy employed was phenomenological study. The respondent was selected using purposive sampling technique considering the compatibility between information and the problem studied. This study was based on constructivism paradigm under the heading of Social Definition paradigm. This Peter L. Berger’s constructivism idea stated that in constructivism idea, learning was based on the students’ understanding.</p><p>The exclusiveness behavioral pattern in the superior students occurred in thought, appearance, space, facility pattern and intercourse. Meanwhile, the process of exclusiveness process establishment occurred since they were stated as passing the admission test in superior class. The factors supporting the establishment of exclusiveness pattern were school policy, parent and student because of the process of interpreting their status as the students of superior class.</p><p> </p><strong>Keywords</strong>: social construction, exclusiveness, superior students.
TEKNOLOGI KOMUNIKASI DAN PERILAKU REMAJA
Authors: Astuti Ana Puji , Rps Anike NUrmalita 
Published: May 2021

<p>Every culture has knowledge, science and technology, which used as a<br />reference for interpreting and understanding the environment and its<br />contents, and used as a tool to exploit, process and use it to satisfy human<br />needs. Communication of technology development is very fast at all. With<br />the development of science and technology people get various facilities in<br />carrying out daily activities. Even as now almost every person can not be<br />separated from the communication technologies, as experienced by young<br />people today. Adolescence is a period of transition from children to adults<br />who are beginning to be affected by the environment and have a willingness<br />to be what he wants himself. With the advances in communication<br />technology spur teens to more intensive self-seeking activities by looking at<br />figures in the media.</p><p> </p><p><br />Keywords: Teknology, behavior, youth.</p>
PERANGKAP KEMISKINAN PADA WARGA RELOKASI (STUDI KORELASIONAL: UNSUR-UNSUR PERANGKAP KEMISKINAN PADA WARGA RELOKASI PUCANG MOJO KEDUNGTUNGKUL MOJOSONGO JEBRES SURAKARTA)
Authors: Nurcahyono Okta Hadi , Slamet Y , Zuber Ahmad 
Published: May 2021

<p>This study is the result of the interpretation of the theory of "Poverty Trap" Robert Chambers (1983) to the social facts paradigm (Emile Dhurkheim, 1964). The purpose of this study was to determine whether or not the resident relocation poverty trap, by way of explaining whether or not the relationship between the elements of the poverty trap in this case: powerlessness, vulnerability, physical weakness, material poverty, and isolation of the Public Service, the citizens relocation Pucang Mojo, Kedungtungkul, Mojosongo, Surakarta. This study uses poverty approach both structurally and culturally. This research is survey research with an explanatory strategy. The study population was all heads of households in Housing Relocation Pucang mojo, Mojosongo, Surakarta.The number of sample was taken 50% out of total population. This study employed quantitative data with triangulation using qualitative data as the confirmer. The qualitative data used was the one derived from result of interview and observation. To examine the relationship between the elements of poverty trap, Product Moment Correlation test was used that was processed with SPSS 19.0 version IBM. The dominant result of statistic data processing in this study was then combined with qualitative data in the discussion. The result of discussion showed that: out of ten relationships between variables or elements existing, only four categorized into significant relationship, while the other six elements were proved insignificant. The four elements are shown to have a significant association among others: the poverty of material with physical weakness, material poverty with vulnerability, physical weakness with vulnerability, and isolation of the public service with the helplessness while the sixth has no correlation relationships such as: poverty with insulating material to public servants, the material poverty with powerlessness, physical weakness with insulation against public servants, physical weakness with powerlessness, isolation against public servants with vulnerability, and vulnerability to helplessness. This finding showed that not all hypotheses suggested by Robert Chambers (1983) could be proved in the context of urban poverty, particularly among the relocated people in Pucangmojo, Kedungtungkul, Mojosongo, Jebres, Surakarta.</p><p> </p><p><strong>Keywords:</strong> poverty trap and</p><p> </p>