bluuebunny/crossref_metadata_2025_split huggingface dataset:
TechQuity is an imperative for health and technology business: Let’s work together to achieve it
Authors: Clark Cheryl R , Akdas Yasemin , Wilkins Consuelo H , Rhee Kyu , Johnson Kevin B , Bates David W , Dankwa-Mullan Irene 
Published: May 2021

Abstract
Open discussions of social justice and health inequities may be an uncommon focus within information technology science, business, and health care delivery partnerships. However, the COVID-19 pandemic—which disproportionately affected Black, indigenous, and people of color—has reinforced the need to examine and define roles that technology partners should play to lead anti-racism efforts through our work. In our perspective piece, we describe the imperative to prioritize TechQuity—equity and social justice as a technology business strategy—through collaborating in partnerships that focus on eliminating racial and social inequities.
Edge-to-edge repair of the systolic anterior motion of mitral valve and cardiac myectomy of the abnormally positioned papillary muscles in an infant with COL4A1 mutation
Authors: Miyairi Satoshi , Takeyoshi Daisuke , Ishikawa Natsuya , Kamiya Hiroyuki 
Published: May 2021

Abstract
Surgical treatment is challenging in pediatric patients with left ventricular outflow tract (LVOT) stenosis (LVOTS). We herein present the case of a 2-year-old male patient with porencephaly who was diagnosed with LVOTS accompanied by moderate mitral valve regurgitation (MR) with systolic anterior motion (SAM). Edge-to-edge mitral valve reconstruction and myectomy of the abnormal cardiac muscle were performed, with an uneventful postoperative course. LVOT myectomy and edge-to-edge mitral valve repair may be considered as a safe and acceptable approach with good clinical outcomes in pediatric patients with LVOTS accompanied by MR with SAM.
Concealed gallbladder perforation: a rare case report
Authors: Suleiman Jamil , Mremi Alex , Tarmohamed Murad , Sadiq Adnan , Lodhia Jay 
Published: May 2021

Abstract
Acute acalculous cholecystitis remains an elusive clinical diagnosis possibly due to complex clinical setting in which this entity develops, lack of large prospective controlled trials that evaluate various diagnostic modalities, thus dependence on a small database for clinical decision making. Concealed gallbladder perforation is rare. Herein, we report an 82-year-old female who presented with a right upper quadrant pain and features of local peritonitis. Abdominal ultrasound was suggestive of cholecystitis while computed tomography (CT) scan reported a perforated gallbladder with pericholecystic fluid collection. The patient underwent successful cholecystectomy; and intra-operatively, similar findings as those reported on imaging were seen. Unfortunately, she succumbed shortly post-operatively due to pulmonary embolism. Our report highlights the importance CT scan in patients with vague abdominal symptoms followed by sudden resolution. It also reminds the importance of considering the diagnosis of concealed gallbladder perforation as a differential in patients with peritonitis, as it may be missed by routine radiological investigations.
Multiwavelength investigation of the candidate Galactic PeVatron MGRO J1908+06
Authors: Crestan S , Giuliani A , Mereghetti S , Sidoli L , Pintore F , La Palombara N 
Published: May 2021

ABSTRACT
The candidate PeVatron MGRO J1908+06, which shows a hard spectrum beyond 100 TeV, is one of the most peculiar γ-ray sources in the Galactic plane. Its complex morphology and some possible counterparts spatially related with the very high energy (VHE) emission region, preclude to distinguish between a hadronic and leptonic nature of the γ-ray emission. In this paper, we illustrate a new multiwavelength analysis of MGRO J1908+06, with the aim to shed light on its nature and the origin of its ultra-high-energy emission. We performed an analysis of the 12CO and 13CO molecular line emission demonstrating the presence of dense molecular clouds spatially correlated with the source region. We also analysed 12 yr of Fermi-Large Area Telescope (LAT) data between 10 GeV and 1 TeV finding a counterpart with a hard spectrum (Γ ∼ 1.6). Our reanalysis of XMM–Newton data allowed us to put a more stringent constraint on the X-ray flux from this source. We demonstrate that a single accelerator cannot explain the whole set of multiwavelength data, regardless of whether it accelerates protons or electrons, but a two-zone model is needed to explain the emission from MGRO J1908+06. The VHE emission seems most likely the superposition of a TeV pulsar wind nebula powered by PSR J1907+0602, in the southern region, and of the interaction between the supernova remnant G40.5−0.5 and the molecular clouds, in the northern region.
The impact of magnetic fields on cosmological galaxy mergers – I. Reshaping gas and stellar discs
Authors: Whittingham Joseph , Sparre Martin , Pfrommer Christoph , Pakmor Rüdiger 
Published: May 2021

ABSTRACT
Mergers play an important role in galaxy evolution. In particular, major mergers are able to have a transformative effect on galaxy morphology. In this paper, we investigate the role of magnetic fields in gas-rich major mergers. To this end, we run a series of high-resolution magnetohydrodynamic (MHD) zoom-in simulations with the moving-mesh code arepo and compare the outcome with hydrodynamic simulations run from the same initial conditions. This is the first time that the effect of magnetic fields in major mergers has been investigated in a cosmologically consistent manner. In contrast to previous non-cosmological simulations, we find that the inclusion of magnetic fields has a substantial impact on the production of the merger remnant. Whilst magnetic fields do not strongly affect global properties, such as the star formation history, they are able to significantly influence structural properties. Indeed, MHD simulations consistently form remnants with extended discs and well-developed spiral structure, whilst hydrodynamic simulations form more compact remnants that display distinctive ring morphology. We support this work with a resolution study and show that whilst global properties are broadly converged across resolution and physics models, morphological differences only develop given sufficient resolution. We argue that this is due to the more efficient excitement of a small-scale dynamo in higher resolution simulations, resulting in a more strongly amplified field that is better able to influence gas dynamics.
MaNGA galaxy properties – I. An extensive optical, mid-infrared photometric, and environmental catalogue
Authors: Arora Nikhil , Stone Connor , Courteau Stéphane , Jarrett Thomas H 
Published: May 2021

ABSTRACT
We present an extensive catalogue of non-parametric structural properties derived from optical and mid-infrared imaging for 4585 galaxies from the MaNGA survey. DESI and Wide-field Infrared Survey Explorer (WISE) imaging are used to extract surface brightness profiles in the g, r, z, W1, W2 photometric bands. Our optical photometry takes advantage of the automated algorithm autoprof and probes surface brightnesses that typically reach below 29 mag arcsec−2 in the r-band, while our WISE photometry achieves 28 mag arcsec−2 in the W1-band. Neighbour density measures and central/satellite classifications are also provided for a large subsample of the MaNGA galaxies. Highlights of our analysis of galaxy light profiles include (i) an extensive comparison of galaxian structural properties that illustrates the robustness of non-parametric extraction of light profiles over parametric methods; (ii) the ubiquity of bimodal structural properties, suggesting the existence of galaxy families in multiple dimensions; and (iii) an appreciation that structural properties measured relative to total light, regardless of the fractional levels, are uncertain. We study galaxy scaling relations based on photometric parameters, and present detailed comparisons with literature and theory. Salient features of this analysis include the near-constancy of the slope and scatter of the size–luminosity and size–stellar mass relations for late-type galaxies with wavelength, and the saturation of central surface density, measured within 1 kpc, for elliptical galaxies with $M_* \gt 10.7\, {\rm M}_{\odot }$ (corresponding to $\Sigma _1 \simeq 10^{10}\, {\rm M}_{\odot }\, {\rm kpc}^{-2}$). The multiband photometry, environmental parameters, and structural scaling relations presented are useful constraints for stellar population and galaxy formation models.
A high-rate foreground of sub-second flares from geosynchronous satellites
Authors: Nir Guy , Ofek Eran O , Ben-Ami Sagi , Segev Noam , Polishook David , Manulis Ilan 
Published: May 2021

ABSTRACT
The Weizmann Fast Astronomical Survey Telescope is a 55 cm optical survey telescope with a high-cadence (25 Hz) monitoring of the sky over a wide field of view (≈7 deg2). The high frame rate allows detection of sub-second transients over multiple images. We present a sample of ∼0.1–0.3 s duration flares detected in an untargeted survey for such transients. We show that most, if not all of them, are glints of sunlight reflected off geosynchronous and graveyard orbit satellites. The flares we detect have a typical magnitude of 9–11, which translates to ∼14–16th magnitude if diluted by a 30 s exposure time. We estimate the rate of events brighter than ∼11 mag to be of the order of 30–40 events per day per deg2, for declinations between −20° and +10°, not including the declination corresponding to the geostationary belt directly above the equator, where the rate can be higher. We show that such glints are common in large area surveys (e.g. Zwicky Transient Facility and Legacy Survey of Space and Time), and that some of them have a point-like appearance, confounding searches for fast transients such as fast radio burst counterparts and gamma-ray bursts (GRBs). By observing in the direction of the Earth’s shadow, we are able to put an upper limit on the rate of fast astrophysical transients of 0.052 deg−2 day−1 (95 per cent confidence limit) for events brighter than 11 mag. We also suggest that the single image, high declination flare observed in coincidence with the GN-z11 galaxy and assumed to be a GRB, is also consistent with such a satellite glint.
Peculiar-velocity cosmology with Types Ia and II supernovae
Authors: Stahl Benjamin E , de Jaeger Thomas , Boruah Supranta S , Zheng WeiKang , Filippenko Alexei V , Hudson Michael J 
Published: May 2021

ABSTRACT
We present the Democratic Samples of Supernovae (DSS), a compilation of 775 low-redshift Type Ia and II supernovae (SNe Ia and II), of which 137 SN Ia distances are derived via the newly developed snapshot distance method. Using the objects in the DSS as tracers of the peculiar-velocity field, we compare against the corresponding reconstruction from the 2M++ galaxy redshift survey. Our analysis – which takes special care to properly weight each DSS subcatalogue and cross-calibrate the relative distance scales between them – results in a measurement of the cosmological parameter combination $f\sigma _8 = 0.390_{-0.022}^{+0.022}$ as well as an external bulk flow velocity of $195_{-23}^{+22}$ km s−1 in the direction $(\ell , b) = (292_{-7}^{+7}, -6_{-4}^{+5})$ deg, which originates from beyond the 2M++ reconstruction. Similarly, we find a bulk flow of $245_{-31}^{+32}$ km s−1 towards $(\ell , b) = (294_{-7}^{+7}, 3_{-5}^{+6})$ deg on a scale of $\sim 30\, h^{-1}$ Mpc if we ignore the reconstructed peculiar-velocity field altogether. Our constraint on fσ8 – the tightest derived from SNe to date (considering only statistical error bars), and the only one to utilize SNe II – is broadly consistent with other results from the literature. We intend for our data accumulation and treatment techniques to become the prototype for future studies that will exploit the unprecedented data volume from upcoming wide-field surveys.
Long-term neuropsychological outcomes of survivors of young childhood brain tumors treated on the Head Start II protocol
Authors: Levitch Cara F , Malkin Benjamin , Latella Lauren , Guerry Whitney , Gardner Sharon L , Finlay Jonathan L , Sands Stephen A 
Published: May 2021

Abstract

Background
The Head Start treatment protocols have focused on curing young children with brain tumors while avoiding or delaying radiotherapy through using a combination of high-dose, marrow-ablative chemotherapy and autologous hematopoietic cell transplantation (AuHCT). Late effects data from treatment on the Head Start II (HS II) protocol have previously been published for short-term follow-up (STF) at a mean of 39.7 months post-diagnosis. The current study examines long-term follow-up (LTF) outcomes from the same cohort.

Methods
Eighteen HS II patients diagnosed with malignant brain tumors &lt;10 years of age at diagnosis completed a neurocognitive battery and parents completed psychological questionnaires at a mean of 104.7 months’ post-diagnosis.

Results
There was no significant change in Full Scale IQ at LTF compared to baseline or STF. Similarly, most domains had no significant change from STF, including verbal IQ, performance IQ, academics, receptive language, learning/memory, visual-motor integration, and externalizing behaviors. Internalizing behaviors increased slightly at LTF. Clinically, most domains were within the average range, except for low average mathematics and receptive language. Additionally, performance did not significantly differ by age at diagnosis or time since diagnosis. Of note, children treated with high-dose methotrexate for disseminated disease or atypical teratoid/rhabdoid tumor displayed worse neurocognitive outcomes.

Conclusions
These results extend prior findings of relative stability in intellectual functioning for a LTF period. Ultimately, this study supports that treatment strategies for avoiding or delaying radiotherapy using high-dose, marrow-ablative chemotherapy and AuHCT may decrease the risk of neurocognitive and social-emotional declines in young pediatric brain tumor survivors.
Global Risk in Long-Term Sovereign Debt
Authors: Borri Nicola , Shakhnov Kirill 
Published: May 2021

Abstract
This paper focuses on emerging market government bonds issued in local currency with different maturities. Foreign investors face interest rate, currency, and credit risks. We consider the entire term structure of carry trade returns and find that, while the default premium does not contribute to carry trade strategies, the contribution of interest rate risk, captured by the term premium, is large and increases with maturity. We introduce default risk in an otherwise standard affine model; we show that the volatility of the permanent component of the SDFs must be different across emerging markets in order to match these stylized facts. (JEL F31, F34, G15)
Received September 9, 2019; editorial decision March 25, 2021 by Editor: Nikolai Roussanov. Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
Unicolumnar Pin Fixation of Type III Supracondylar Humeral Fractures Is Associated With Over 3 Times Higher Odds of Lost Reduction
Authors: Jenkins Sarah M. , Mehlman Charles T. , Denning Jaime Rice 
Published: May 2021

Objectives:
To compare the rate of lost reduction between 2 groups of non–age-segregated type III supracondylar humeral fracture patients: a unicolumnar versus bicolumnar fixation group.

Design:
Retrospective cohort study.

Setting:
Pediatric Academic Trauma Center.

Patients:
We identified 257 patients with type III supracondylar humerus fractures from surgical billing records over a 5-year period. There were 183 patients identified with bicolumnar fixation (71.2%) and 74 patients identified with unicolumnar fixation (28.8%).

Intervention:
Closed reduction percutaneous pinning of the distal humerus.

Main Outcome Measures:
The primary outcome measure was difference in rate of lost reduction between patients with bicolumnar (lateral and medial column) and unicolumnar (lateral column only) fixation (Fig. 1). The reduction and fixation at the time of fluoroscopy was assessed using the Baumann angle, Gordon index, and anterior humeral line. Loss of reduction was assessed at time of healing, defined by a Baumann angle change ≥10 degrees and Gordon index of ≥50% (Fig. 2).

Results:
There were 183 patients with bicolumnar fixation and 74 patients with unicolumnar fixation included in the study (average age 5.8 years; range, 2–14 years). The rate of lost reduction in patients with bicolumnar fixation was 6.01% (11/183), whereas 17.57% (13/74) of patients with unicolumnar fixation experienced lost reduction. These rates were significantly different (P = 0.008) with a 3.3 times higher odds (95% confidence interval = 1.3–8.6) of lost reduction with unicolumnar fixation.

Conclusions:
There is a statistically significant increase in the rate of supracondylar fracture loss of reduction for patients with unicolumnar fixation when compared with bicolumnar fixation.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Spitz Melanoma of Childhood With A Novel Promoter Hijacking Anaplastic Lymphoma Kinase (C2orf42-ALK) Rearrangement
Authors: Frederico Ingrid K. S. , Mesbah Ardakani Nima , Ryan Annie L. , Cowley Mark J. , Wood Benjamin A. 
Published: May 2021

Abstract:
We present the case of a prepubescent man of African descent who developed a spitzoid melanocytic proliferation showing evidence of a novel promoter hijacking ALK-C2orf42 rearrangement, with atypical histology, clinically apparent metastatic disease, and abnormal cytogenetic findings, representing a rare genuine case of “Spitz melanoma of childhood.” As our understanding of the distinct molecular biology of different tumors traditionally grouped as spitzoid melanocytic lesions evolves, it is becoming increasingly apparent that this group encompasses morphologically and genetically distinct entities. Accurate classification with detailed molecular analysis and prolonged clinical follow-up is essential to allow meaningful conclusions regarding prognostication and prediction of response to therapy.
Cutaneous Pseudolymphoma With Langerhans Cell Hyperplasia—A Rare Case With Clinical Presentation Mimicking Malignancy and Potential Diagnostic Pitfall
Authors: Ye Cian-Hao , Chen Chih-Jung , Chang Kung-Chao , Wu Yu-Hung , Chen Mei-Ling , Chiu Tsu-Man 
Published: May 2021

Abstract:
We describe a rare case of cutaneous pseudolymphoma with Langerhans cell hyperplasia. An 84-year-old female patient presented with erythematous and pernicious-looking plaques on her scalp that had been present for months. Histologically, lymphoid follicles consisting of mixed-type lymphocytes and Langerhans cells were aggregated focally. The diagnosis was verified by several immunohistochemical stains and by clinical evaluation. Skin lesions were steadily resolved with low-dose corticosteroid and hydroxychloroquine.
Clinical and Histopathologic Characteristics of Metastatic and Locally Advanced Cutaneous Basal Cell Carcinomas
Authors: Baker Laura X. , Grilletta Erica , Zwerner Jeffrey P. , Boyd Alan S. , Wheless Lee 
Published: May 2021

Abstract:
Locally advanced or metastatic basal cell carcinomas (laBCCs or mBCCs) are rare, with few case series providing information on their epidemiology. We aimed to describe the clinical and histologic features of locally advanced and metastatic basal cell carcinomas. Forty cases of laBCC or mBCC were identified by searching Vanderbilt's database from 1984 to January 2019. A retrospective chart review was performed. Pathology slides were available for 23 cases (13 mBCCs and 10 laBCCs). Twenty-one of 23 cases were Clark level IV or V, with a mean depth of invasion of >7 mm for both types. The mean mitotic rate was 4.4 mitoses/mm2 for laBCCs and 3.3 mitoses/mm2 for mBCCs. Ulceration was identified in 7 laBCC and 8 mBCC cases. Perineural invasion was present in 2 laBCC and 6 mBCC cases, with 3 mBCCs invading nerves >0.1 mm. Of 13 mBCC cases, histologic subtypes included infiltrative (n = 9), nodular (n = 7), morpheaform (n = 4), and superficial (n = 2), with multiple patterns present in some specimens. 10 of 13 patients with mBCC had local recurrence before metastasis. In summary, we identified several potential markers of high-risk BCC, including perineural invasion, deep invasion, elevated mitotic rate, and local recurrence of the primary tumor.
Simulation-Based Interpretation of Therapeutically Monitored Cabozantinib Plasma Concentration in Advanced Adrenocortical Carcinoma with Hemodialysis
Authors: Zimmermann Sebastian , Kurlbaum Max , Mayer Stefanie , Fassnacht Martin , Kroiss Matthias , Scherf-Clavel Oliver 
Published: May 2021

Background:
Adrenocortical carcinoma is an orphan but aggressive malignancy with limited treatment options. Cabozantinib (CAB), a tyrosine kinase inhibitor, has emerged as a new potential treatment. However, no data are available on whether and how CAB can be administered to patients undergoing hemodialysis.

Methods:
An liquid chromatography with tandem mass spectrometry detection method was developed and validated according to the European Medicines Agency and United States Food and Drug Administration guidelines for bioanalytical method validation. The samples were prepared using protein precipitation and online solid-phase extraction. The method was applied to clinical samples of an adrenocortical carcinoma patient receiving CAB treatment (80 mg daily). During the 10 days of observation, the patient received periodic hemodialysis on 7 days. Pharmacokinetic (PK) simulations were performed using Bayesian forecasting according to an existing population PK model for CAB.

Results:
Based on the PK simulation, a mean plasma trough concentration of 1375 ng/mL [90% prediction interval (PI), 601–2602 ng/mL] in the steady state at a daily dose of 80 mg was expected for CAB. However, an individual simulation involving the measured plasma levels of the patient resulted in a mean trough concentration of 348 ng/mL (90% PI, 278–430 ng/mL). The model based on individual PK parameters estimated accessible plasma levels of 521, 625, and 834 ng/mL by dose adjustment to 100, 120, and 160 mg, respectively.

Conclusions:
After establishing an liquid chromatography with tandem mass spectrometry detection method for therapeutic drug monitoring of CAB, our analyses involving a single patient undergoing hemodialysis indicated that higher than expected doses of CAB were required to achieve reasonable plasma concentrations. Our study demonstrates the usefulness of therapeutic drug monitoring for the evaluation of “new” drugs in patients with renal impairment.
INADVERTENT GLOBE PENETRATION AND SUBRETINAL INJECTION OF BOTULINUM TOXIN IN A PATIENT WITH OCULOCUTANEOUS ALBINISM
Authors: Aljohani Saud , AlJaloud Ahmad , Alsakran Wael A. , AlZaid Abdulrahman 
Published: May 2021

Purpose:
To present a case of localized retinal detachment and mild vitreous hemorrhage in a patient with oculocutaneous albinism after accidental intraocular injection of botulinum toxin A.

Methods:
Botulinum toxin A injection was administered to a 5-year-old patient with oculocutaneous albinism with esotropia and resulted in an ocular penetration. Dilated fundus examination indicated a nasal retinal tear causing a mild vitreous hemorrhage and a localized retinal detachment.

Results:
No treatment was required for the retinal detachment, and we observed the patient at regular intervals. On Day 1, the detachment resolved spontaneously without sequelae. On follow-up, scarring at the lesion site was detected at one month after the incidence, and the patient's vision was stable.

Conclusion:
In this instance, observation was sufficient for our patient with complete resolution of retinal detachment and no long-term complication. Botulinum toxin A did not seem toxic to intraocular tissues. However, intramuscular botulinum toxin A injection should be administered carefully. Oculocutaneous albinism did not seem to affect the final outcome in our case.