bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the efficacies of 1.0mm and 1.5mm silicone tubes for the treatment of nasolacrimal duct obstruction
Authors: Nakamura Jutaro , Kamao Tomoyuki , Mitani Arisa , Mizuki Nobuhisa , Shiraishi Atsushi 
Published: December 2021

Abstract

Purpose:
We compared the difference in postoperative patency rates due to the differences in the diameter of silicone tubes used for bicanalicular intubation for the treatment of nasolacrimal duct obstruction (NLDO).
Methods:
Patients diagnosed with NLDO at Ehime University Hospital between August 2013 and November 2020 who underwent endoscopic-assisted nasolacrimal duct intubation (ENDI) were included in the study. The patients involved were 130 cases and 157 sides (age 72.6 ± 11.3 years) who were eligible for follow-up for more than six months after the removal of the lacrimal silicone tube. The postoperative recurrence rate was compared retrospectively based on the difference in tube caliber. The patients were divided into two groups: those intubated with a 1.5-mm large diameter tube (Group LD) and those with a 1.0-mm normal diameter tube (Group ND). The survival rates of the two groups at one year after tube removal were compared by Kaplan-Meier's curve and Restricted mean survival time (RMST) method with τ = 365 days.
Results:
There were no significant differences in age, gender, or observation period after tube removal between the two groups. Meanwhile, the preoperative occlusion period was significantly longer in the ND group. The recurrence rate after tube removal was significantly lower in the LD group (12 / 85 sides, 14.1%) compared to the ND group (27 / 72 sides, 37.5%) (p = 0.001). The patency rate at one year after removal of the lacrimal tube was 0.857 (0.754-0.919) in the LD group and 0.739 (0.617-0.828) in the ND group. In comparing patency rates by the RMST method at τ = 365 days, the RMST difference, RMST ratio, and RMTL ratio were significantly higher in the LD group at p = 0.045, 0.052, and 0.046, respectively.
Conclusion:
Regarding the bicanalicular silicone tube intubation, the patency rate at one year after removal was significantly higher in the thicker tubes with a diameter of 1.5 mm compared with that of a diameter of 1.0 mm for the treatment of NLDO.
Efficacy of COVID-19 vaccine booster doses in older people
Authors: Mattiuzzi Camilla , Lippi Giuseppe 
Published: December 2021

Abstract
Purpose. We provide here an updated analysis on efficacy of COVID-19 vaccine booster doses in older people (i.e., aged ≥80 years) based on ongoing Italian nationwide COVID-19 vaccination campaign. Methods. Data were obtained from the COVID-19 national integrated surveillance program, made available and regularly updated by the Italian National Institute of Health.Results. Compared to those who completed the COVID-19 vaccination cycle for ≥5 months (n=2.385.897), those receiving booster doses (n=1.549.747) had 75% lower risk of SARS-CoV-2 infection, 82-83% lower risk of COVID-19 hospitalization and ICU admission, and 81% lower risk of death. Administration of COVID-19 vaccine boosters generated also greater protection (between 63-87% higher) against all these same endpoints compared to early completing (i.e., <5 months; n=335.458) a primary COVID-19 vaccination cycle.Conclusions. The administration of COVID-19 vaccine booster doses is advisable for reducing the risk of morbidity and mortality in older people.
A Modified Extrema Pattern with Multilinear Matrix Decomposition based RLC scheme for Efficient Serial Remote Sensing Images Mining
Authors: R Angelin Preethi , Anandharaj G. 
Published: December 2021

Abstract
The growth of serial remote sensing images (SRSI) offers abundant information for determining sequential spatial patterns in several fields like vegetation cover, urban development, and agricultural monitoring. Or else, traditional sequential pattern-mining algorithms cannot be applied efficiently or directly to remote sensing images. Here a new technique is proposed for enhancing the mining efficacy of spatial sequential patterns from raster serial remote sensing images (SRSI) based on pixel grouping approach. The modified extrema pattern is employed to offering grey-scale invariant transform of intensity values unlike previously employed local ternary pattern. The pattern features are computed by transformation process from which the multilinear matrix decomposition of the image is made by computing the covariance estimation on recognizing their orthogonal component. The matrix decomposition is then attained based on run length encoding process (RLC). The two rows of RLC vectors are intersected to attain pixel group matrix. Finally, the compressed image is attained in an efficient manner with effective mining time. The performance outcome reveals that the technique offered in this paper is capable of extracting spatial sequential patterns from SRSI effectively. The proposed system ensures that the entire patterns are extracted at a lower time consumption.
Convolutional Neural Networks Ensembles Through Single-Iteration Optimization
Authors: Ribeiro Luiz Carlos Felix , de Rosa Gustavo Henrique , Rodrigues Douglas , Papa João Paulo 
Published: December 2021

Abstract
Convolutional Neural Networks have been widely employed in a diverse range of computer vision-based applications, including image classification, object recognition, and object segmentation. Nevertheless, one weakness of such models concerns their hyperparameters' setting, being highly specific for each particular problem. One common approach is to employ meta-heuristic optimization algorithms to find suitable sets of hyperparameters at the expense of increasing the computational burden, being unfeasible under real-time scenarios. In this paper, we address this problem by creating Convolutional Neural Networks ensembles through Single-Iteration Optimization, a fast optimization composed of only one iteration that is no more effective than a random search. Essentially, the idea is to provide the same capability offered by long-term optimizations, however, without their computational loads. The results among four well-known literature datasets revealed that creating one-iteration optimized ensembles provide promising results while diminishing the time to achieve them.
Cartesianism, argumentation, values in the context of Chaïm Perelman’s «New Rhetoric»
Authors: Semenikhin I. V. 
Published: December 2021

The article deals with the process of founding and further development of the new rhetoric, a theory of argumentation developed by the Belgian philosopher Chaïm Perelman (1912-1984) and his co-worker Lucie Olbrechts-Tyteca (1899-1987). The intellectual and philosophical backgrounds of the authors and some key characteristics of their theoretical approaches are described. The new rhetoric: (а) is primarily concerned with argument or practical reasoning, (b) suggests that figures of speech may be arguments instead of merely ornaments, (c) with its goal to influence minds, new rhetoric is a dynamic field of study, (d) it is complimentary rather than in opposition to formal reasoning. According to Perelman, the theory of argumentation conceived as a new rhetoric or dialectic, covers the whole range of discourse that aims at persuasion and conviction, whatever the audience addressed and whatever the subject matter. Perelman presents his new rhetoric as a much better form of logic than Cartesian deductive, stringent reasoning, at least where law and other values-based systems are concerned. Perelman challenged the unwholesome assumption that what we cannot know with mathematical certainly is necessarily arbitrary, irrational, and subjective. Perelman recognized "reasoned conviction" as a bridge to knowledge, although he was aware that it was a less perfect source of cognition than verified certainty.
It is explained how the idea of developing the new rhetoric was born out of dissatisfaction with logical positivism or neopositivism (The Vienna Circle’s theories and ideas) and which classical and modern sources inspired the authors in developing a specific logic of value judgments that could deal with argumentation about actions, choices, decisions and without dismissing such argumentation as irrational. The rhetorical framework of the theory is expounded and an overview is provided of the key notions and concepts of Perelman’s ‘new rhetoric’ – the notions of adherence, audience (particular and universal audience), persuasion are explained. According to Perelman, the new rhetoric is based on the idea that since argumentation aims at securing the adherence of those to whom it is addressed, it is, in its entirety, relative to the audience to be influenced. Рerelman's position on the difference between formal logic and argumentation is analyzed.
Oridonin Induces Oxidative Stress-mediated Cancer Cells Apoptosis via Targeting Thioredoxin Reductase
Authors: Duan Dongzhu , Wang Xiaoling , Feng Xiaolu , Pan Dabo , Wang Le , Wang Yanru 
Published: December 2021

Background:
Thioredoxin reductase (TrxR) plays vital role in regulating cellular redox
balance as well as redox-mediated signal transduction. Accumulating evidence supports that
overactivation of TrxR is closely related to tumorigenesis and that targeting TrxR ablation reverses
the growth of numerous malignant tumors, making TrxR a promising target for cancer
chemotherapy. Thus, the discovery and development of molecules as promising anticancer agents
that target TrxR is of great significance. Oridonin was shown to inhibit TrxR activity, but the
detailed cellular mechanism is largely unknown.

Objective:
The study investigated the mechanism of action and underlying inhibitory properties of
oridonin on TrxR in HeLa cells.

Methods:
A covalent docking was performed to reveal the possible interaction between oridonin
and TrxR by Schrödinger Software Suite. TrxR activity was determined by 5,5’-dithiobis-2-
nitrobenzoic acid reduction assay and endpoint insulin reduction assay. Sulforhodamine B and
colony formation assay were employed to assess the viability and growth of cells. Reactive oxygen
species level was measured by probe 2’, 7’-dichlorfluorescein diacetate, and dihydroethidium.
Hoechst 33342 staining, caspase 3 activation, and fluorescein-5-isothiocyanate-conjugated Annexin
V and propidium iodide double staining were used to evaluate apoptosis.

Results:
Here, we reported the oridonin as a potent inhibitor of TrxR. Inhibition of TrxR results in a
decrease of thiols content and total glutathione, elevates reactive oxygen species levels, and finally
promotes oxidative stress-mediated apoptosis of cancer cells.

Conclusion:
Targeting TrxR by oridonin discloses a novel molecular mechanism underlying the
biological action of oridonin and sheds light on developing oridonin as a potential tumor therapeutic
agent.
CAR-NK Cells for Cancer Therapy: Molecular Redesign of the Innate
Antineoplastic Response
Authors: Rojas-Martinez Augusto , Cienfuegos-Jimenez Oscar , Vazquez-Garza Eduardo 
Published: December 2021

:
The Chimeric Antigen Receptor (CAR) has arisen as a powerful synthetic biology-based
technology with demonstrated versatility for implementation in T and NK cells. Despite CAR T
cell successes in clinical trials, several challenges remain to be addressed regarding adverse events
and long-term efficacy. NK cells present an attractive alternative with intrinsic advantages over T
cells for treating solid and liquid tumors. Early preclinical and clinical trials suggest at least two
major advantages: improved safety and an off-the-shelf application in patients due to its HLA independence.
Due to the early stages of CAR NK translation to clinical trials, limited data is currently
available. By analyzing these results, it seems that CAR NK cells could offer a reduced probability
of Cytokine Release Syndrome (CRS) or Graft versus Host Disease (GvHD) in cancer patients, reducing
safety concerns. Furthermore, NK cell therapy approaches may be boosted by combining it
with immunological checkpoint inhibitors and by implementing genetic circuits to direct CAR-bearing
cell behavior. This review provides a description of the CAR technology for modifying NK
cells and the translation from preclinical studies to early clinical trials in this new field of immunotherapy.
Metabolomics Work Flow and Analytics in Systems Biology
Authors: Chacko Sanoj , Haseeb Yumna B. , Haseeb Sohaib 
Published: December 2021

:Metabolomics is an omics approach of systems biology that involves the development and assessment of large-scale, comprehensive biochemical analysis tools for metabolites in biological systems. This review describes the metabolomics workflow and provides an overview of current analytic tools used for the quantification of metabolic profiles. We explain analytic tools such as mass spectrometry (MS), nuclear magnetic resonance (NMR) spectroscopy, ionization techniques, and approaches for data extraction and analysis.
Prognostic Value of Long Non-coding RNAs in Urological Malignancies: A Systematic Review, and Meta-Analysis
Authors: Bagheri Zeinab , Arjmand Mohammad-Hassan 
Published: December 2021

Background:
Many studies have explored the potential roles of long non-coding RNAs (lncRNAs) in urological cancer (UC) progression. The clinical outcome and prognosis of UCs remain weak. Therefore, finding clinical prognostic markers is needed to improve therapeutic potential. The aim of this study was to consider the possible association between the lncRNAs expression with the survival time and clinical outcomes in patients with UC.

Methods:
A literature search was performed in several related databases to find eligible English papers published before 9 February 2021. Hazard ratios (HRs) with 95% CI were calculated to investigate the association between lncRNAs expression and overall survival in patients with UC.

Results:
A total of 46 studies, including 39 lncRNAs were identified. Results indicated that lncRNAs expression was significantly correlated with poor overall survival (OS) outcome in patients with UCs (HR: 1.923, 95% CI: 1.448-2.554, P<0.001). Also, we divided included studies into up-regulated and down-regulated subgroups according to lncRNAs expression. The results indicated a significant association with poor OS outcomes in both up-regulated (HR=2.546, 95% CI: 1.896-3.41, P<0.001) and down-regulated (HR=0.33, 95% CI: 0.22-0.49, P<0.001). Moreover, expression of lncRNAs was significantly associated with lymph node metastasis (LNM) (OR=0.25, 95% CI: 0.13-0.47, P<0.001)

Conclusion:
Abnormal expression of various lncRNAs is a potential novel marker for predicting the clinical outcomes of urological tumors.
COVID-19 impacts on virtual exchange around the world
Authors: Bali Maha , Goes Paulo , Haug Eva , Patankar Anita 
Published: December 2021

The COVID-19 pandemic has simultaneously created both opportunities and challenges for the emerging field of virtual exchange: On one hand, institutional administrators and funding organisations saw virtual exchange as the solution to global learning needs while physical travel was restricted and traditional mobility programmes were suspended. On the other hand, instructors felt overwhelmed by transitioning all of their teaching online, and without physical access to their educational institutions, many students and instructors lacked reliable internet connections or safe places to engage in learning, not to mention the financial burdens of the pandemic.
This moderated panel discussion which took place during the IVEC 2020 conference invited diverse perspectives to explore the impacts of the pandemic on virtual exchange in various contexts around the world. Central to the discussion were issues of equity, inclusion and justice: Is virtual exchange truly a more accessible and equitable form of global learning, as it is often promoted to be?
In this video contribution, Eva Haug moderates the conversation between Maha Bali, Paulo Goes, and Anita Patankar around the following questions.
* How is virtual exchange a solution to global learning during COVID-19?
* What have been the two to three most relevant impacts of the pandemic on virtual exchange activity at your institution, in your country, or region of the world?
* How can we as a field of practitioners maintain and sustain the current momentum and interest in VE in a post-COVID-19 world?
* Can intercultural exchange be apolitical?
* If an institution is in a position of power or privilege, how can they create space in virtual exchange for institutions that are less represented?

The video recording is accessible on: https://vimeo.com/459415071 (CC BY-NC-NC)
The Successes and Challenges of Implementing Telehealth for Diverse Patient Populations Requiring Prenatal Care During COVID-19: Qualitative Study
Authors: Farrell Ruth , Collart Christina , Craighead Caitlin , Pierce Madelyn , Chien Edward , Frankel Richard , Tucker Edmonds Brownsyne , Perni Uma , Coleridge Marissa , Ranzini Angela C , Rose Susannah 
Published: December 2021

Background
Although telehealth appears to have been accepted among some obstetric populations before the COVID-19 pandemic, patients’ receptivity and experience with the rapid conversion of this mode of health care delivery are unknown.

Objective
In this study, we examine patients' prenatal care needs, preferences, and experiences during the COVID-19 pandemic, with the aim of supporting the development of successful models to serve the needs of pregnant patients, obstetric providers, and health care systems during this time.

Methods
This study involved qualitative methods to explore pregnant patients’ experiences with prenatal health care delivery at the onset of the COVID-19 pandemic. We conducted in-depth interviews with pregnant patients in the first and second trimester of pregnancy who received prenatal care in Cleveland, Ohio, from May to July 2020. An interview guide was used to probe experiences with health care delivery as it rapidly evolved at the onset of the pandemic.

Results
Although advantages of telehealth were noted, there were several concerns noted with the broad implementation of telehealth for prenatal care during the pandemic. This included concerns about monitoring the pregnancy at home; the need for additional reassurance for the pregnancy, given the uncertainties presented by the pandemic; and the ability to have effective patient-provider discussions via a telehealth visit. The need to tailor telehealth to prenatal health care delivery was noted.

Conclusions
Although previous studies have demonstrated that telehealth is a flexible and convenient alternative for some prenatal appointments, our study suggests that there may be specific needs and concerns among the diverse patient groups using this modality during the pandemic. More research is needed to understand patients' experiences with telehealth during the pandemic and develop approaches that are responsive to the needs and preferences of patients.
Formulation of Anti Acne Sheet Mask from Bandotan Leaf Extract (Ageratum conyzoides L.) against Propionibacterium acnes
Authors: Ginting Pricella , Leny Leny , Hafiz Ihsanul , Hasibuan Romauli 
Published: December 2021

Acne can occur due to increased sebum excretion, inflammation of the skin triggered by the bacteria Propionibacterium acnes, Staphylococcus epidermidis, Staphylococcus aureus. The purpose of this study was to determine the formulation of sheet mask preparations of bandotan leaf extract (Ageratum conyzoides L.) in inhibiting the growth of Propionibacterium acnes bacteria. This type of research is an experimental study which include plant identification, making ethanol extract of bandotan leaves, making sheet mask formulations, evaluating the characteristics of the preparation and testing antibacterial activity using disc paper method using Mueller Hinton Agar media. The extract was carried out by maceration using 70% ethanol as a solvent. Testing the effectiveness of antibacterial by measuring the diameter of the inhibition zone, after that the data were analyzed using the One Way ANOVA statistical test. The results of the evaluation of the preparation showed that the preparation was homogenous, with pH ranging from 4.5 to 6.5 and the preparation did not cause irritation on volunteers skin. The results of the inhibition zone measurements showed that the inhibition zones at 2.5% concentration is 4.7mm, 5% (6.83mm), 7.5% (10.2mm) and positive control (20.57mm). This means that the higher the concentration, the larger the diameter of the inhibition zone obtained. The conclusion in this study is bandotan leaf extract (Ageratum conyzoides L.) can be formulated into anti acne sheet mask which is stable during storage with a strong inhibitory power at 7.5% concentration, which is 10.2 mm.
Keywords: Ageratum conyzoides L., bandotan leaf, Propionibacterium acnes, sheet mask
Perancangan Aplikasi Sistem Informasi Penyewaan Gedung Serbaguna Wilayah Jakarta Barat
Authors: Agustami Sundari , Mutu Manikam Ratna 
Published: December 2021

Abstract The development of the day is increasingly rapidly, as well as technological advances. Especially in computerised field. Computer is a tool to help work primarily in the field of business. Therefore, the community needs technology to complete its work and the presence of computer technology that is increasingly modern, fast and practical greatly affects the life of the wider community. The speed and accuracy of the information usually takes a long time, now in just a matter of seconds the information we can already receive. By looking at the development of computer technology today, it is very important for the business world to improve the customer service and provide facilities in the rental service of West Jakarta area. Some buildings in West Jakarta are currently booking the building is still done manually so that it can cause errors and loss on consumer data data. In this case, the design of information system will be done to help booking a multipurpose building in West Jakarta area. Design to be created using UML. With the computerized can achieve effective activities in conducting activities on the building reservations. Keywords: Information, system design, multipurpose building reservations, UML AbstrakPerkembangan zaman semakin hari semakin pesat, begitu juga dengan kemajuan teknologi. Terutama dibidang komputerisasi. komputer merupakan alat untuk membantu pekerjaan terutama dibidang bisnis. oleh karena itu, masyarakat membutuhkan teknologi untuk menyelesaikan pekerjaannya Dan adanya teknologi komputer yang semakin modern, cepat dan praktis sangat mempengaruhi kehidupan masyarakat luas. Kecepatan dan keakuratan informasi yang biasanya memerlukan waktu yang lama, kini hanya dalam hitungan detik informasi tersebut sudah dapat kita terima. Dengan melihat perkembangan teknologi komputer saat ini, hal yang sangat penting bagi dunia bisnis adalah untuk meningkatkan pelayanan konsumen dan memberikan kemudahan dalam pelayanan penyewaan gedung serbaguna wilayah Jakarta barat. Beberapa gedung di Jakarta barat saat ini pemesanan gedung masih dilakukan secara manual sehingga dapat menyebabkan kesalahan dan kehilangan pada data data konsumen. Dalam hal ini akan dilakukan perancangan sistem informasi untuk membantu pemesanan gedung serbaguna wilayah Jakarta barat. Perancangan yang akan dibuat menggunakan Unified Modeling Language(UML). Dengan adanya komputerisasi dapat tercapainya kegiatan yang efektif dalam melakukan aktifitas pada pemesanan gedung. Kata kunci: perancangan , sistem informasi, pemesanan, gedung serbaguna, UML