bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contando histórias, resgatando memórias: Arte como mediadora para o resgate de trajetórias e memórias de crianças migrantes
Authors: Silva Graziela Lucchesi Rosa da , Gabriel Maria , Aoto Camila Akemi , Lubke Luana , Abreu e Lima Luisa Martins de , Osman Mayssun Omari , Tsiflidis Nathalia , Klepa Victória De Biassio 
Published: May 2021

Ante o contexto migratório contemporâneo, é fundamental a elaboração de ações promotoras de desenvolvimento voltadas às especificidades da infância, considerando os impactos do deslocamento forçado nesse período da vida. Sob tal direção, a ação extensionista Pequenos do Mundo, da Universidade Federal do Paraná (UFPR), foi elaborada. No presente artigo, apresentamos e discutimos, a partir dos fundamentos da Psicologia Histórico-Cultural, a metodologia desenvolvida, valendo-se da arte em suas diferentes expressões e manifestações para o resgate e a valorização das memórias afetivas das crianças e de suas famílias, sobre cultura de origem, trajetórias e vivências. Em contraposição a um apagamento cultural sofrido em migrações involuntárias, desenvolvemos uma proposta e consequentes ações em que as crianças pudessem ouvir histórias, contar as suas e, nesse processo, se reconhecerem e reconhecerem os outros. As ações possibilitaram a elaboração simbólica e material sobre processos culturais e identitários, e, nesse processo, as crianças tomam posse para si de uma ferramenta que promove o resgate e o compartilhamento de aspectos da sua relação com seus pares e com o meio, apropriando-se e transformando suas histórias.
Preface
Authors: Rennert Hal , Shoaf Judy 
Published: May 2021

Business as usual in the face of more than 257,000 fellow Americans dyingfrom the coronavirus?—the business of editing Delos, a scholarly journal ofliterary translations, somewhat removed from the physical manifestationswhere our sisters and brothers, the first responders in the hospitals nursing homes and schools, are employed. Together, our survival and livelihoods are at risk in the current pandemic.
There are many historical and literary precedents for what we are goingthrough today, beginning with Boccaccio in the fourteenth century and culminating with Albert Camus’s novel The Plague (La Peste, 1947), which he effectively employed as a symbol of Nazi ideology and occupation of France, and as a warning against mass hysteria for future generations, not merely for students of the political process and future epidemiologists, but for ordinary citizens like us.
Recent Developments in the Crystallization of PLLA-Based Blends, Block Copolymers, and Nanocomposites
Authors: Kumar Pandey Amit , Sakurai Shinichi 
Published: May 2021

Despite the extensive studies of poly(L-lactic acid)(PLLA), the crystallization of PLLA-based materials is still not completely understood. This chapter presents recent developments of crystallization of PLLA-based blends, block copolymers and nanocomposites. The first section of the chapter discusses the acceleration of PLLA crystallization by the inclusion of biobased (solid and liquid state) additives. It was found that the solid state additives work as a nucleating agent while the liquid-state additive works as a plasticizer. Both type of the additives can significantly enhance the crystallization of PLLA, as indicated by crystallization half-time (t0.5) values. Such composites are of great interest as they are 100% based on renewable resources. The second section talks about the enhanced formation of stereocomplex (SC) crystals in the PLLA/PDLA (50/50) blends by adding 1% SFN. It was found that the loading of SFN enhances the formation of SC crystals and it suppresses the formation of HC (homocrystal). The third section deals with confined crystallization of poly(ethylene glycol) (PEG) in a PLLA/PEG blend. The PLLA/PEG (50/50) blend specimen was heated up to 180.0°C and kept at this temperature for 5 min. Then, a two-step temperature-jump was conducted as 180.0°C → 127.0°C → 45.0°C. For this particular condition, it was found that PEG can crystallize only in the preformed spherulites of PLLA, as no crystallization of PEG was found in the matrix of the mixed PLLA/PEG amorphous phase. The last section describes the confined crystallization of PCL in the diblock and triblock copolymers of PLA-PCL. Furthermore, enantiomeric blends of PLLA-PCL and PDLA-PCL or PLLA-PCL-PLLA and PDLA-PCL-PDLA have been examined for the purpose of the improvement of the poor mechanical property of PLLA to which the SC formation of PLLA with PDLA components are relevant.
Treatment Approaches of Multiple Myeloma
Authors: Alebachew Woldu Minyahil , Mulu Fentie Atalay , Assefa Tadesse Tamrat 
Published: May 2021

Multiple Myeloma (MM) is the most common malignant neoplasm of plasma cells that accumulate in bone marrow, leading to bone destruction and marrow failure. Clinical investigation of MM requires the evaluation of bone marrow for plasma cell infiltration, and detection and quantification of monoclonal protein in the serum or urine, and evidence for end-organ damage (i.e., hypercalcemia, renal insufficiency, anemia, or bone lesions). The overall goal of treatment of MM is to improve survival. The treatment landscape and clinical outcome of MM have changed in the last two decades, with an improved median survival of 8–10 years. Management of MM involves induction, consolidation, and maintenance therapy. Currently, Autologous stem cell transplant (ASCT) is considered as the standard care of treatment for newly diagnosed fit MM patients. Multiple combinations of proteasome inhibitors (PIs) and immunomodulatory drugs (IMIDs) such as Thalidomide, lenalidomide, and pomalidomide have been under evaluation in ASCT-eligible and ineligible settings, and studies are still ongoing. For patients with ASCT-eligible newly diagnosed MM, induction therapy with triple drugs should contain an IMiD, a PI, and a corticosteroid, usually lenalidomide-bortezomib-dexamethasone. For ASCT-ineligible patients on lenalidomide with dexamethasone (Rd), with addition of bortezomib or daratumumab can be considered.
Clear cell adenocarcinoma of the male urethra: clinical case report
Authors: Santos Juliana Sinezio , Mendes Gabriella Oliveira , Monteiro Fernando Sabino Marques 
Published: May 2021

ABSTRACTPrimary clear cell adenocarcinoma of the urethra is a rare malignancy and most of the cases described are in women. The symptomatology is similar to other tumors of the urethra. Because it is a rare malignancy and the consequent lack of trials in the medical literature, there is no data about the most appropriate treatment for this disease. We aim to describe a clinical case of primary clear cell adenocarcinoma of the urethra in a young male patient. This is a 36-year-old male diagnosed with primary clear cell adenocarcinoma of the urethra whom underwent a surgery for localized disease and about 30 months later he had a local and systemic recurrence. He was treated with platinum-based chemotherapy and presented an excellent clinical and radiological response. Although there is no optimal treatment for this malignancy, in the case of metastatic disease, systemic platinum-based chemotherapy should be considered an appropriate option.
Multi-scale analysis of the characteristics of the changing landscape of the typical mountainous region of Southwest China over the past 40 years
Authors: Liu Fang , Wang Wanbin , Wang Jinliang , Zhang Xingzi , Ren Jing , Liu Yuexiong 
Published: May 2021

Context
Yunnan Province is an important ecological security barrier in China. This study investigated the temporal and spatial changes to landscape ecology and is of great significance for guiding landscape protection and future socio-economic development.

Objectives
To analyze the temporal and spatial changes of the landscape patterns at the county, river basin, and provincial levels, and clarify and describe the temporal and spatial differentiation characteristics of the landscape patterns in Yunnan Province.

Methods
Based on landscape ecology, GIS spatial analysis, and spatio-temporal change analysis, nine landscape pattern indices, and spatial autocorrelation for different years, were calculated.

Results
The landscape of Yunnan Province has evolved as a whole toward isolation. The indices of separation and fragmentation changed significantly from 2010 to 2015. From 2015 to 2018 the rate of fragmentation decreased. Fragmentation in the Nu Jiang and Irrawaddy River basins was less than in other basins. The landscape patterns of the Jinsha and Pearl River basins were relatively fragmented due to human activity, socioeconomic development, and utilization. The differences between the Lancang and Red River Basins were relatively small and at an intermediate level.

Conclusions
Spatial autocorrelation analysis indicated that there are three areas with typical clusters, namely the Hengduan Mountains where the degree of fragmentation of the landscape was low, while landscape connectivity and aggregation were high. The subtropical region of Southern Yunnan displayed high landscape heterogeneity, a complex shape index, and high connectivity and sprawl. Central Yunnan exhibited a fragmented landscape with poor connectivity and aggregation. These three regions correspond with “the three screens and two belts” in the Main Functional Planning Area of Yunnan Province.
Consequences of herbal mixture supplementation on milk performance, ruminal fermentation, and bacterial diversity in water buffaloes
Authors: Hassan Faizul , Tang Zhenhua , Ebeid Hossam M. , Li Mengwei , Peng Kaiping , Liang Xin , Yang Chengjian 
Published: May 2021

This study was aimed to evaluate the potential of a herbal mixture (HM) to improve production performance, rumen fermentation, and milk fatty acid profile in water buffaloes. Sixteen Murrah buffaloes (in four groups) were fed for 10 weeks with the same basal diet supplemented with 0 (control); 20 (HM20), 30 (HM30), and 40 (HM40) g/buffalo per day. The herbal mixture contained an equal quantity of black pepper (fruit), ginger (tubers), cinnamon (bark), peppermint (leaves), ajwain (seeds) and garlic (bulbs). After two weeks of adaptation, daily milk yield, and weekly milk composition were recorded. On the last day of the experiment, rumen contents were collected to determine rumen fermentation parameters and bacterial diversity through 16S rRNA sequencing. Results revealed no effect of treatment on dry matter intake (DMI), rumen fermentation parameters, and daily milk yield. However, milk fat (%) showed a tendency to increase (p = 0.07) in HM20 as compared with the control group. A significant increase in mono and polyunsaturated fatty acids (C14:1, C16:1, C18:2n6 and C18:3) whereas a decrease in saturated fatty acids (C18:0) in milk was observed in HM20 as compared with the control group. No significant change in bacterial diversity parameters (alpha and beta diversity) was observed in response to the treatment. Despite the substantial variation observed in the relative abundance of bacteria among treatment groups, no significant effect of treatment was observed when compared with the control group. Correlation analysis revealed several positive and negative correlations of rumen bacteria with rumen volatile fatty acids (VFA) and milk yield traits. Bacterial genera including Succinivibrionaceae, Butyrivibrio, Pseudobutyrivibrio, and Lachnospiraceae showed a positive correlation with VFA and milk yield traits. Overall, we observed 52 positive and 10 negative correlations of rumen bacteria with milk fatty acid contents. Our study revealed the potential of the herbal mixture at a lower supplemental level (20 g/day) to increase milk fat (%) and unsaturated fatty acid content in buffalo.
DZNep, an inhibitor of the histone methyltransferase EZH2, suppresses hepatic fibrosis through regulating miR-199a-5p/SOCS7 pathway
Authors: Ding Rongrong , Zheng Jianming , Li Ning , Cheng Qi , Zhu Mengqi , Wang Yanbing , Zhou Xinlan , Zhang Zhanqing , Shi Guangfeng 
Published: May 2021

Background
Hepatic fibrosis is a common response to chronic liver injury. Recently, the role of DZNep (a histone methyltransferase EZH2 inhibitor) in repressing pulmonary and renal fibrosis was verified. However, the potential effect of DZNep on hepatic fibrosis has not been elucidated.

Methods
The hepatic fibrosis model was established in rats treated with CCl4 and in hepatic stellate cells (HSCs) treated with TGF-β1. The liver tissues were stained with H&E and Masson’s trichrome. The expression of EZH2, SOCS7, collagen I, αSMA mRNA and miR-199-5p was assessed using qPCR, immunohistochemical or western blot analysis. A dual-luciferase reporter assay was carried out to validate the regulatory relationship of miR-199a-5p with SOCS7.

Results
The EZH2 level was increased in CCl4-treated rats and in TGF-β1-treated HSCs, whereas DZNep treatment significantly inhibited EZH2 expression. DZNep repressed hepatic fibrosis in vivo and in vitro, as evidenced by the decrease of hepatic fibrosis markers (α-SMA and Collagen I). Moreover, miR-199a-5p expression was repressed by DZNep in TGF-β1-activated HSCs. Notably, downregulation of miR-199a-5p decreased TGF-β1-induced expression of fibrosis markers. SOCS7 was identified as a direct target of miR-199a-5p. The expression of SOCS7 was decreased in TGF-β1-activated HSCs, but DZNep treatment restore d SOCS7 expression. More importantly, SOCS7 knockdown decreased the effect of DZNep on collagen I and α SMA expression in TGF-β1-activated HSCs.

Conclusions
DZNep suppresses hepatic fibrosis through regulating miR-199a-5p/SOCS7 axis, suggesting that DZNep may represent a novel treatment for fibrosis.
Oxidative stress induces cell death partially by decreasing both mRNA and protein levels of nicotinamide phosphoribosyltransferase in differentiated PC12 cells
Authors: Zhou Cuiyan , Ying Weihai 
Published: May 2021

Background.
Multiple studies have indicated crucial roles of NAD+ deficiency in several neurological diseases and aging. It is critical to discover the mechanisms underlying the NAD+ deficiency. A decreased level of Nicotinamide phosphoribosyltransferase (Nampt)—an important enzyme in the salvage pathway of NAD+ synthesis—has been found under certain pathological conditions, while the mechanisms underlying the Nampt decrease are unclear. The purpose of this study is to test the hypothesis that oxidative stress can produce decreased Nampt, and to investigate the biological effects of Nampt on NAD+ synthesis and cell survival under both basal and oxidative stress conditions.

Methods.
We used differentiated PC12 cells as a cellular model to investigate the effects of oxidative stress on the levels of Nampt. Multiple assays, including flow cytometry-based cell death assays and NAD+ assays were conducted.

Results.
First, oxidative stress can decrease the levels of Nampt mRNA and Nampt protein; second, Nampt plays significant roles in NAD+ synthesis under both basal conditions and oxidative stress conditions; third, Nampt plays critical roles in cell survival under both basal conditions and oxidative stress conditions; and fourth, oxidative stress produced decreased NAD+ levels and cell survival partially by decreasing Nampt. Collectively, our study has indicated that oxidative stress is a pathological factor leading to decreased Nampt, which plays important roles in oxidative stress-produced decreases in NAD+ levels and cell survival. Our findings have indicated major roles of Nampt in maintaining NAD+ levels and cell survival under both basal and oxidative stress conditions.
DNA barcoding of Austrian snow scorpionflies (Mecoptera, Boreidae) reveals potential cryptic diversity in Boreus westwoodi
Authors: Zangl Lukas , Glatzhofer Elisabeth , Schmid Raphael , Randolf Susanne , Koblmüller Stephan 
Published: May 2021

Background
Snow scorpionflies (genus Boreus) belong to a family of Mecoptera, Boreidae, that has been vastly neglected by entomological researchers due to their shift in seasonality to the winter months. Their activity during this time is regarded as a strategy for predator avoidance and regular sightings on snow fields suggest that this also facilitates dispersal. However, many aspects about snow scorpionflies, especially systematics, taxonomy, distribution of species, phylogenetics and phylogeography have remained fairly unexplored until today. In this study, we fill some of these gaps by generating a reference DNA barcode database for Austrian snow scorpionflies in the frame of the Austrian Barcode of Life initiative and by characterising morphological diversity in the study region.

Methods
Initial species assignment of all 67 specimens was based on male morphological characters previously reported to differ between Boreus species and, for females, the shape of the ovipositor. DNA barcoding of the mitochondrial cytochrome c oxidase subunit 1 (COI) gene was carried out for all 67 samples and served as a basis for BIN assignment, genetic distance calculations, as well as alternative species delimitation analyses (ABGD, GMYC, bGMYC, bPTP) and a statistical parsimony network to infer phylogenetic relationships among individual samples/sampling sites.

Results
Morphological investigations suggested the presence of both Boreus hyemalis and Boreus westwoodi in Austria. DNA barcoding also separated the two species, but resulted in several divergent clades, the paraphyly of B. westwoodi in Austria, and high levels of phylogeographic structure on a small geographic scale. Even though the different molecular species delimitation methods disagreed on the exact number of species, they unequivocally suggested the presence of more than the traditionally recognized two Boreus species in Austria, thus indicating potential cryptic species within the genus Boreus in general and especially in B. westwoodi.
Impact of Zinc Fertilization on Yield, Yield Attributes and Quality Parameters of Finger Millet Varieties under Rainfed alfisols of Southern Zone, Andhra Pradesh
Authors: Mrudula G. , Rani P. Sandhya , Sreekanth B. , Nagamadhuri K. V. , Luther M. Martin 
Published: May 2021

Aims: To study the effect of zinc fertilization through soil and foliar at different stages of finger millet on yield, yield attributes and quality in two major finger millet varieties under rainfed alfisols of southern zone, Andhra Pradesh
Study Design: Split-plot design
Place and Duration of Study: Wetland farm, S.V Agricultural College, Tirupati and during kharif season of 2019 and 2020 (Two seasons)
Methodology: Zinc fertilization to two major finger millet varieties viz., Vakula and Tirumala through soil and foliar application at different crop stages with following treatments viz., Control (No fertilizers and manures); RDF (60 -30-20 kg N-P-K + FYM @ 4 t ha-1); RDF + soil application of ZnSO4 @ 25 kg ha-1 as basal; RDF+Soil application of chelated-ZnSO4 @ 5 kg ha-1; RDF+foliar application of 0.2% ZnSO4 at ear head emergence stage; RDF+foliar application of 0.2% ZnSO4 at grain filling stage; and RDF+foliar application of 0.2% ZnSO4 at ear head emergence and grain filling stage. The yield, yield attributes and quality parameters viz., protein, zinc and iron content in grains were determined by adopting standard protocols.
Results: The application of zinc significantly (p<0.05) improved the yield and quality parameters over control. The foliar application of 0.2% ZnSO4 at ear head emergence and grain filling stage was significantly (p≤0.05) improved the yield and yield attributes of finger millet over RDF. The grain yield, straw yield, no. of productive tillers per plant, no. of fingers per plant were increased to 57.0%, 83.2%, 44.6% and 51.7%, respectively over RDF i.e., 60-30-20 kg N-P-K + FYM @ 4 t ha-1. The quality parameters namely protein, grain zinc and iron also increased up to 40.7%, 69.5% and 43.2%, respectively over RDF.
Conclusion: Application of zinc sulphate at ear head emergence and grain filling stages enhanced the yield, yield parameters and quality parameters compared to other treatments of tirumala variety under rainfed alfisols of southern zone of Andhra Pradesh.
Gastro-intestinal Stromal Tumor Complicated by an Acute Intestinal Occlusion: A Case Report
Authors: Elbakouri A. , Zouhair A. , Bensardi F. Z. , Bouali M. , Elhattabi K. , Fadil A. 
Published: May 2021

Gastrointestinal stromal tumours (GISTs) are rares connective tumors, usually located in the stomach or small intestine. Derived from Cajal cells or one of their precursors.
Gastrointestinal stromal tumors (GISTs) represent 1% to 2% of all neoplasms of the digestive tract, The average age is between 50 and 60 years old, most often occurring in the stomach, Their clinical symptomatology is variable according to the region affected or the size of the lesion, they are responsibles for digestive bleeding, pain, or abdominal mass, as well as an alteration in the general state of health. More rarely, the diagnosis is made on the occasion of an intestinal occlusion. the GIST complicated by occlusion due either to invagination of the tumour mass or to exophytic development of the tumour. In CT scans, they are manifested by a localised parietal tumour thickening of variable size with most often an exophytic development. Molecular biology plays an important role in this disease.
The main treatment is radical surgery .The Imatinib has radically changed the prognosis of patients with unresectable and/or metastatic GIST.
We report the case of a patient with a stromal tumour complicated by occlusion operated in emergency in the department of visceral surgical emergencies of Ibn Rochd UHC.
Recalling a recent meal reduces desire and prospective intake measures for pictures of palatable food
Authors: Arthur Phoebe , Stevenson Richard J. , Francis Heather M. 
Published: May 2021

AbstractRecalling what was eaten at a meal today, relative to yesterday, reduces subsequent food intake. We explored one cause of this effect by examining how this memory manipulation affects food specific (desire/how much you would eat) and general (hunger) motivation to eat. Participants rated hunger before random assignment to either recall their last meal (experimental) or lunch yesterday (control). They then judged specific motivation to eat a set of palatable foods (as pictures), followed by hunger ratings and a measure of dietary restraint. Specific motivation to eat was significantly lower in the experimental group, even though hunger ratings increased following exposure to food images in both groups. Dietary restraint was negatively correlated with specific motivation to eat in controls, but not in the experimental group, and these two relationships significantly differed. We suggest an explicit cognitive process akin to dietary restraint inhibits specific motivation to eat following last meal recall.
Beyond Photo: Xdynamic Therapies in Fighting Cancer
Authors: Wang Sheng , Tian Rui , Zhang Xu , Cheng Guohui , Yu Peng , Chang Jin , Chen Xiaoyuan 
Published: May 2021

AbstractReactive oxygen species (ROS)‐related therapeutic approaches are developed as a promising modality for cancer treatment because the aberrant increase of intracellular ROS level can cause cell death due to nonspecific oxidation damage to key cellular biomolecules. However, the most widely considered strategy, photodynamic therapy (PDT), suffers from critical limitations such as limited tissue‐penetration depth, high oxygen dependence, and phototoxicity. Non‐photo‐induced ROS generation strategies, which are defined as Xdynamic therapies (X = sono, radio, microwave, chemo, thermo, and electro), show good potential to overcome the drawbacks of PDT. Herein, recent advances in the development of Xdynamic therapies, including the design of systems, the working mechanisms, and examples of cancer therapy application, are introduced. Furthermore, the approaches to enhance treatment efficiency of Xdynamic therapy are highlighted. Finally, the perspectives and challenges of these strategies are also discussed.