bluuebunny/crossref_metadata_2025_split huggingface dataset:
The web‐based self‐reported survey of Alcohol Use Disorders Identification Test and associated factors in Japan
Authors: Toyama Tomomi , Nitta Chie , Koga Yoshiki , Hamanaka Kaoru , Kimura Mitsuru , Matsushita Sachio 
Published: December 2024

AbstractAimWhile considerable data on the alcohol drinking behavior of the general population are available for the United States and Europe, data from Asian countries are scarce. We attempted to estimate the social backgrounds and other factors associated with high Alcohol Use Disorders Identification Test (AUDIT) scores in Japan.MethodsThis web‐based survey was conducted in 2023. In order to ensure the representativeness of the sample, the population distribution by age and region was determined from the Statistics Bureau Census Basic Population Summary. The survey questionnaire items included AUDIT, educational background, occupation, income, marital status, body mass index (BMI), age at the time of the first alcoholic drink, age at the start of habitual drinking, Kessler Psychological Distress Scale (K6), and Link's Devaluation Discrimination Scale.ResultsA total of 40,720 responses were received from people aged between 20 and 75 years old. The proportion of potential alcohol use disorder based on AUDIT score ≥15 was 9.2% in men and 2.0% in women. The number of people with AUDIT scores ≥15 tended to be high in men in their 50s and women in their 20s and 40s. Among those with AUDIT scores ≥15, the age at the first drink and age at the start of habitual drinking were significantly lower, and the K6 score was significantly higher.ConclusionThis web survey showed an association between AUDIT scores and age at first drinking and mental health condition. Since this survey was a web‐monitored survey, caution should be taken in generalizing the prevalence.
A green synthesis route of ZnO/polyhydroxybutyrate composites with antibacterial and biodegradable properties
Authors: Ladhari Safa , Vu Nhu‐Nang , Bastien Juliette Vallée , Tran Bich Van , Nguyen Thi Ha , Saidi Alireza , Barnabe Simon , Sollogoub Cyrille , Nguyen‐Tri Phuong 
Published: December 2024

AbstractThe development of environmentally friendly polymer‐based materials with antibacterial and biodegradable properties is bringing significant benefits to the packaging industry. In the present work, green‐synthesized zinc oxide microporous particles (ZnO MPs) are dispersed in the poly(3‐hydroxybutyrate) (PHB) matrix using a simple casting method to prepare bioactive films with improved antibacterial and anti‐biofouling properties. The resultant films display a microporous morphology with a uniform dispersion of ZnO MPs within the polymeric matrix. The incorporation of green‐synthesized ZnO MPs (3% wt) into PHB films leads to potent antibacterial activity, notably under LED light, with bacterial inactivation efficiencies of 97.5% and 76.2% against Escherichia coli and Staphylococcus epidermidis, respectively, after 90 min of light irradiation. This antibacterial activity is superior to that induced by films loaded with the same amount of commercial ZnO nanoparticles. Furthermore, the potent antibacterial activity gives rise to improved anti‐biofouling for prepared films, in which the biofilm formation on their surface is effectively eliminated. Notably, the ZnO MP incorporation improves the microbe adhesion, accelerating the biodegradation of developed films, with soil biodegradation rates reaching 99% in 10 weeks. The present work offers a simple and cost‐effective approach to producing promising composites with prolonged shelf‐life and the capability of reducing bacterial contamination for packaging industry applications.Highlights
99% bacterial inhibition for Escherichia coli and 95% for Staphylococcus epidermidis.
Microfiltration efficiency >99% achieved in one filtration cycle.
Mechanical strength is enhanced by 2.2 times with the addition of gelatin.
Biofouling resistance by preventing bacterial attachment.
Sustainable membranes with fast biodegradation in soil.
PI‐RADS in Predicting csPCa: A Comparison Between Academic and Nonacademic Centers
Authors: Orsini Angelo , Ferretti Simone , Porreca Annamaria , Castellan Pietro , Litterio Giulio , Ciavarella Davide , De Palma Antonio , Berardinelli Francesco , Pizzi Andrea D. , D'Angelo Emanuela , di Nicola Marta , Schips Luigi , Marchioni Michele 
Published: December 2024

ABSTRACTIntroductionThe introduction of multiparametric prostate magnetic resonance imaging (mpMRI) has revolutionized prostate cancer (PCa) diagnosis, enhancing the localization of clinically significant prostate cancer (csPCa) and guiding targeted biopsies. However, significant disparities in the execution, interpretation, and reporting of prostate MRI examinations across centers necessitate greater standardization and accuracy. This study compares the diagnostic efficacy of mpMRI from academic and nonacademic centers in detecting csPCa and identifies factors associated with csPCa detection.Materials and MethodsBetween July 2018 and October 2023, we prospectively followed 810 men at SS. Annunziata Hospital of Chieti who underwent MRI/US fusion biopsies due to elevated prostate‐specific antigen (PSA) and/or abnormal digital rectal examination (DRE). Patients with mpMRI‐documented suspicious lesions classified as PI‐RADS ≥ 3 were included. Patients were divided into two groups based on the source of their mpMRI (academic or nonacademic centers). All biopsies were conducted using the MRI/US fusion technique. Clinical, mpMRI, and pathological data were collected and analyzed. Statistical analyses were performed using R software.ResultsThe cohort included 354 patients from academic centers and 456 from nonacademic centers. There were no significant differences in patient demographics, such as age and PSA levels, between the groups. Patients at academic centers were more likely to receive a higher number of elevated PI‐RADS scores compared to those at nonacademic centers (PI‐RADS > 3: 72.6% vs. 62.3%, p = 0.003). Histopathological analysis revealed no significant differences in the ISUP grade distribution between groups. Increased age, PSA levels, and positive DRE were significantly associated with higher odds of detecting csPCa. Median PSA density was significantly higher in patients with csPCa compared to those without csPCa (0.14 vs. 0.11 ng/mL/cm³, p < 0.001). Academic centers exhibited a higher odds ratio for csPCa detection in patients with PI‐RADS scores > 3 compared to nonacademic centers.ConclusionOur study highlights significant variability in PI‐RADS score assignments between academic and nonacademic centers, affecting csPCa detection rates. This variability underscores the need for greater standardization in PI‐RADS scoring to reduce disparities and improve diagnostic uniformity across centers.
Peristaltic transport of ethylene glycol‐based graphene oxide non‐Newtonian nanofluid through an endoscope
Authors: Akbar Noreen Sher , Akram Javaria , Qureshi Muhammad Ahmer , Muhammad Taseer 
Published: December 2024

AbstractEndoscopy, in medical sciences, is a modern mechanism for the examination of internal remote organs by the direct insertion of the illuminated tube inside the body. It also transports the fluid with the movement of contraction and relaxation. The current study aims to explore the peristaltic propulsion of ethylene glycol‐based graphene oxide nanofluid through an endoscope. The considered nanofluid depicts shear‐thinning aspects, which are described by the Carreau–Yasuda fluid model. The modified Darcy's law is employed to describe the porosity of the medium. For a precise calculation, the modified Buongiorno model is adopted with the incorporated Maxwell's model, Brownian motion parameter, and variable for the thermophoresis effect. The mathematical problem linearized under the lubrication approach is solved numerically through Mathematica. After using the experimentally found values of Carreau–Yasuda fluid parameters for different levels of nanoparticle proportion, It is concluded that there is a slight decline in the velocity and the temperature of the nanofluid. Furthermore, a larger Biot number contributes significantly to the heat transfer coefficient. Fluid flow is assisted by a rise in the Darcy porosity parameter. For an increment in the strength of the buoyancy forces, there is a significant uplift in the fluid's temperature and the velocity.
Convergence Almost Everywhere of Partial Sums and Féjer Means of Vilenkin–Fourier Series
Authors: Areshidze N. , Persson L.-E. , Tephnadze G. 
Published: December 2024

AbstractWe characterize subsequences $$\{S_{n_k}\}$$

{

S

n
k

}

of partial sums with respect to (bounded or unbounded) Vilenkin systems of $$f\in L^1(G_m)$$

f
∈

L
1

(

G
m

)

for which almost everywhere convergence holds. Moreover, we construct an explicit $$f\in L^p(G_m), \ 1\le p<\infty $$

f
∈

L
p

(

G
m

)

,

1
≤
p
<
∞

whose partial sums (satisfying the same conditions which guarantee almost everywhere convergence) diverges on any set of measure zero. We also prove a similar divergence result for Vilenkin–Féjer means.
A new human autologous hepatocyte/macrophage co-culture system that mimics drug-induced liver injury–like inflammation
Authors: Zimmermann Andrea , Scheffschick Andrea , Hänsel René , Borchardt Hannes , Liu Jia Li , Ehnert Sabrina , Schicht Gerda , Seidemann Lena , Aigner Achim , Schiffmann Susanne , Nüssler Andreas , Seehofer Daniel , Damm Georg 
Published: December 2024

Abstract
The development of in vitro hepatocyte cell culture systems is crucial for investigating drug-induced liver injury (DILI). One prerequisite for monitoring DILI related immunologic reactions is the extension of primary human hepatocyte (PHH) cultures towards the inclusion of macrophages. Therefore, we developed and characterized an autologous co-culture system of PHH and primary human hepatic macrophages (hepM) (CoC1). We compared CoC1 with a co-culture of the same PHH batch + M0 macrophages derived from THP1 cells (CoC2) in order to represent a donor independent macrophage reaction. Then, we treated the mono- and co-cultures with drugs that cause DILI—menadione (MEN, 1 or 10 µM, 3 h), diclofenac (DIC, 0.5 or 5 mM, 6 h), or acetaminophen (APAP, 0.5 or 5 mM, 6 h)—and assessed culture stability, cell activity, macrophage differentiation, cytokine production and cell viability. Without drug treatment, CoC1 was the most stable over a culture time of up to 60 h. Cytokine array analysis revealed a proinflammatory profile of PHH mono-cultures due to isolation stress but showed different influences of hepM and M0 on the cytokine profile in the co-cultures. MEN, DIC and APAP treatment led to donor-dependent signs of cell stress and toxicity. HepM can either promote or reduce the DILI effects donor dependently in CoC1. CoC2 are slightly less sensitive than CoC1 in representing DILI. In summary, we present a new autologous co-culture system that can mimic DILI in a donor-dependent manner. This cellular system could be useful for new drug testing strategies and reducing animal testing.
Significant variation in the assessment and management of screen-detected colorectal polyp cancers
Authors: Hallam Sally , Farrugia Alexia , Naumann David N. , Trudgill Nigel , Rout Shantanu , Karandikar Sharad 
Published: December 2024

Abstract
Purpose
Endoscopic resection is appropriate for selected colorectal polyp cancers, but significant variation exists in treatment. This study aims to investigate variation in management of screen-detected polyp cancers (T1), factors predicting primary endoscopic polypectomy and threshold for subsequent surgical resection.

Method
Patients with polyp cancers (T1) diagnosed by the bowel cancer screening programme (BCSP) were investigated at two screening centres (5 individual sites and 4 MDTs, 2012–2022). Patient demographics, pathological characteristics, management and outcomes were recorded. Variation in management was compared between sites. Risk factors for primary endoscopic polypectomy and the need for subsequent surgical resection were analysed using multivariable binary logistic regression models.

Results
Of 220 polyp cancers, 178 (81%) underwent primary endoscopic resection. Secondary surgical excision was required in 54 (30%). Study sites were not significantly different in their primary management for colonic or rectal polyps. Only the size of colonic polyps was associated with primary surgery rather than endoscopic polypectomy (OR 1.05 (95% CI 1.00–1.11); p = 0.038). There was a difference between study sites in the odds ratio for secondary surgery after primary polypectomy for colonic polyps (OR 3.97 (95% CI 1.20–16.0); p = 0.033) but not rectal. Other factors associated with the requirement for secondary surgery were as follows: sessile morphology for colonic polyps (OR 2.92 (95% CI 1.25–6.97); p = 0.013) and en-bloc resection for rectal polyps (OR 0.14 (0.02–0.85); p = 0.043).

Conclusion
There was significant variation in the assessment and treatment of colonic polyp cancers. Standardising pathology reporting and treatment algorithms may lead to better consistency of care and a reduction in secondary surgery.
A retrospective, multicentric, nationwide analysis of the impact of splenectomy on survival of pancreatic cancer patients
Authors: Kießler Maximilian , Jäger Carsten , Mota Reyes Carmen , Pergolini Ilaria , Schorn Stephan , Göß Rüdiger , Safak Okan , Martignoni Marc E. , Novotny Alexander R. , Uhl Waldemar , Werner Jens , Ghadimi Michael , Hartwig Werner , Ruppert Reinhard , Keck Tobias , Bruns Christiane J. , Oldhafer Karl-Jürgen , Schnitzbauer Andreas , Germer Christoph-Thomas , Sommer Florian , Mees Sören Torge , Brunner Maximilian , Köninger Jörg , Glowka Tim R. , Kalff Jörg C. , Reißfelder Christoph , Bartsch Detlef K. , Kraus Thomas , Padberg Winfried , Piso Pompiliu , Lammers Bernhard J. , Rudolph Hagen , Moench Christian , Farkas Stefan , Friess Helmut , Ceyhan Güralp O. , Demir Ihsan Ekin 
Published: December 2024

Abstract
Objective
Splenectomy is regularly performed in total and distal pancreatectomy due to technical reasons, lymph node dissection and radicality of the operation. However, the spleen serves as an important organ for competent immune function, and its removal is associated with an increased incidence of cancer and a worse outcome in some cancer entities (Haematologica 99:392–398, 2014; Dis Colon Rectum 51:213–217, 2008; Dis Esophagus 21:334–339, 2008). The impact of splenectomy in pancreatic cancer is not fully resolved (J Am Coll Surg 188:516–521, 1999; J Surg Oncol 119:784–793, 2019).

Methods
We therefore compared the outcome of 193 pancreatic cancer patients who underwent total or distal pancreatectomy with (Sp) or without splenectomy (NoSp) between 2015 and 2021 using the StuDoQ|Pancreas registry of the German Society for General and Visceral Surgery. In addition, we integrated our data into the existing literature in a meta-analysis of studies on splenectomy in pancreatic cancer patients.

Results
There was no difference between the Sp and NoSp groups regarding histopathological parameters, number of examined or affected lymph nodes, residual tumor status, or postoperative morbidity and mortality. We observed a significantly prolonged survival in pancreatic cancer patients who underwent total pancreatectomy, when a spleen-preserving operation was performed (median survival: 9.6 vs. 17.3 months, p = 0.03). In this group, splenectomy was identified as an independent risk factor for shorter overall survival [HR (95%CI): 2.38 (1.03 – 6.8)]. In a meta-analysis of the existing literature in combination with our data, we confirmed splenectomy as a risk factor for a shorter overall survival in pancreatic cancer patients undergoing total pancreatectomy, distal pancreatectomy, or pancreatic head resection [HR (95%CI): 1.53 (1.11 – 1.95)].

Conclusion
Here, we report on a strong correlations between removal of the spleen and the survival of pancreatic cancer patients undergoing total pancreatectomy. This should encourage pancreatic surgeons to critically assess the role of splenectomy in total pancreatectomy and give rise to further investigations.
Component size dependent lignin-carbohydrate complex adsorption at crystalline cellulose surfaces
Authors: Kou Zhennan , Tolmachev Dmitry , Vuorte Maisa , Sammalkorpi Maria 
Published: December 2024

Abstract
The materials characteristics of natural wood but also the properties of artificial cellulose/hemicellulose-based wood-inspired composite materials result from the molecular level organization and interactions between cellulose, hemicellulose, and lignin. Here, we use atomistic detail molecular dynamics simulations to examine the adsorption of model lignin-carbohydrate complexes (LCCs) consisting of a glucomannan polysaccharide chain with differing lignin fragment linkages to the crystalline facets of cellulose nanocrystals. The findings show that on crystalline cellulose surfaces exceeding in surface dimensions the length of the adsorbed hemicellulose chain, the LCCs can adopt orientations both parallel and perpendicular to the surface chains with response depending on the crystalline facet. The observation of perpendicular orientations is unexpected, as previous molecular level modelling studies systematically report parallel LCC adsorption orientation, however on cellulose interfaces modelling the narrow natural wood cellulose fibrils. Here, the perpendicular adsorption orientation is stabilized by extensive hydrogen bonding and adsorption of the hemicellulose chain with negligible chain bending. Overall, the results show that component dimensions (hemicellulose chain length vs cellulose crystalline surface dimensions) combined with understanding the differences of adsorption response at the difference crystal facets are crucial in understanding wood-inspired materials.

Graphical abstract
Lower semi-continuity of Lagrangian volume
Authors: Çınelı Erman , Ginzburg Viktor L. , Gürel Başak Z. 
Published: December 2024

AbstractWe study lower semi-continuity properties of the volume, i.e., the surface area, of a closed Lagrangian manifold with respect to the Hofer- and γ-distance on a class of monotone Lagrangian submanifolds Hamiltonian isotopic to each other. We prove that volume is γ-lower semi-continuous in two cases. In the first one the volume form comes from a Kähler metric with a large group of Hamiltonian isometries, but there are no additional constraints on the Lagrangian submanifold. The second one is when the volume is taken with respect to any compatible metric, but the Lagrangian submanifold must be a torus. As a consequence, in both cases, the volume is Hofer lower semi-continuous.
Cucurbita ficifolia regulates the secretomes of adipocytes and macrophages in co-culture, breaking meta-inflammation
Authors: Alarcon-Aguilar F. J. , Rosiles-Alanis R. W. , Blancas-Flores G. , Fortis-Barrera M. A. , Flores-Saenz J. L. , Alarcon-Villaseñor E. F. , Giacoman-Martínez A. , Mora-Ramiro B. , Almanza-Pérez J. C. 
Published: December 2024

AbstractCucurbita ficifolia’s fruit aqueous extract has been attributed with antidiabetic and anti-inflammatory properties, offering a promising alternative in addressing meta-inflammation. Meta-inflammation plays a pivotal role in the development of metabolic dysfunction, contributes to conditions such as obesity, diabetes mellitus, and metabolic syndrome. The interactions between adipocytes and macrophages within adipose tissue cause the onset of meta-inflammation, leading to disruptions in the secretomes and transcriptomes of inflammatory cytokines among other factors. We evaluated the effects of the aqueous extract from the fruit of Cucurbita ficifolia on the secretomes and transcriptomes of 3T3-L1 adipocytes and RAW-264.7 macrophages, by exchange of their conditioned mediums and in co-culture conditions. Adipocytes incubated with conditionate medium from macrophages treated with the extract exhibited an increase in GLUT-4 expression, and the protein release of TNFα, accompanied by a reduction in IL-1β. In contrast, macrophages incubated with conditionate medium from adipocytes treated with the extract exhibited inhibition the release of TNFα, IL-6, and IL-10, with TLR-4 expression reduction. Interestingly, under the conditions of indirect simultaneous co-culture, the release of TNFα, IL-6, and IL-1β was disrupted, increasing PPARγ expression in 3T3-L1 adipocytes. The salicin, compound reported in Cucurbita ficifolia extract, had a similar effect in this last model. The aqueous extract of Cucurbita ficifolia demonstrates the ability to suppress meta-inflammation by correcting the secretion patterns of TNFα and IL-6 in co-culture conditions. It effectively modulates the interactions between 3T3-L1 adipocytes and RAW-264.7 macrophages, leading to an improvement in the inflammatory cytokines profile.
Trustworthy AI: responses to commentators
Authors: Kelp Christoph , Simion Mona 
Published: December 2024

AbstractIn ‘Trustworthy Artificial Intelligence’, we develop a novel account of how it is that AI can be trustworthy and what it takes for an AI to be trustworthy. In this paper, we respond to a suite of recent comments on this account, due to J. Adam Carter, Dong-yong Choi, Rune Nyrup, and Fei Song. We would like to thank all four for their thoughtful engagement with our work, as well as the Asian Journal of Philosophy for publishing the symposium on our paper. The game plan for the paper is as follows. We will first briefly rehearse the account and then respond to comments in turn.
Control of dicamba/glufosinate/glyphosate-resistant volunteer soybean in corn with preemergence and postemergence herbicides
Authors: Singh Mandeep , Jhala Amit J. 
Published: December 2024

Abstract
The widespread adoption of multiple-herbicide-resistant corn and soybean often causes the problem of volunteers in corn–soybean rotation, which necessitates alternative herbicides for effective management. The objective of this research was to evaluate PRE and POST herbicides labeled in corn for control of dicamba/glufosinate/glyphosate-resistant volunteer soybean. Field experiments were conducted from 2021 to 2023 near Clay Center, NE. Two separate field experiments were conducted to evaluate 12 PRE and 14 POST herbicides to control volunteer soybean in Enlist® corn. Soybean resistant to dicamba/glufosinate/glyphosate was planted perpendicular to corn rows to mimic volunteer soybean. Among the PRE herbicides tested, acetochlor/clopyralid/flumetsulam (1,190; 1,050/106/34 g ai ha−1) and acetochlor/clopyralid/mesotrione (2,304; 1,961/133/210 g ai or ae ha−1) provided 97% and 99% control of volunteer soybean, respectively, in 2021 and 68% and 89% control, respectively, in 2023 at 42 d after PRE. Among POST herbicides tested, 2,4-D choline (1,064 g ae ha−1), acetochlor/clopyralid/mesotrione (2,304; 1,961/133/210 g ai or ae ha−1), atrazine/bicyclopyrone/mesotrione/S-metolachlor (2,409; 700/42/168/1,499 g ai ha−1), clopyralid/flumetsulam (192; 146/46 g ai ha−1), nicosulfuron + atrazine (34 + 1,120 g ai ha−1), and thiencarbazone-methyl/tembotrione + atrazine (76; 12/63 + 896 g ai ha−1) provided ≥97% volunteer soybean control, ≥94% density reduction, and ≥97% biomass reduction 28 d after POST herbicide application. Corn yield did not differ from the weed-free control in these treatments. The results of this study suggest that PRE and POST herbicides are available for control of dicamba/glufosinate/glyphosate-resistant volunteer soybean in Enlist® corn and that careful selection of an herbicide is required based on the herbicide-resistant soybean planted in the previous year.