bluuebunny/crossref_metadata_2025_split huggingface dataset:
C3 Glomerulonephritis Associated with Monoclonal Gammopathy of Renal Significance
Authors: Gomes-Alves Inês , Castro-Ferreira Inês 
Published: April 2021

Introduction: Monoclonal gammopathy of renal significance (MGRS) is described as a hematologic condition characterized by nephrotoxicmonoclonal proteins produced by a non-malignant B-cell or plasma cell clone. Nevertheless, MGRS can cause serious renal lesions, leading to high morbidity. In C3 glomerulonephritis, a monoclonal protein can cause renal damage indirectly. Acting as an autoantibody, the protein cannot be detected in the kidney biopsy, promoting the dysregulation of the alternative pathway of the complement system.Material and Methods: This non-systematic review was based on a comprehensive search in databases and scientific journals, such as PubMed, Nature Reviews Nephrology and Kidney International, including the terms ‘C3 Glomerulonephritis’ and ‘Monoclonal gammopathy of renal significance’. We review the pathophysiology, presentation, diagnosis, differential diagnosis and treatment of C3 glomerulonephritis associated with MGRS.Discussion: With the increasing understanding of the complex interaction between monoclonal gammopathy and renal damage, such as C3 glomerulonephritis, it becomes clear that an early recognition is crucial, as Ig-directed therapy might improve outcomes. In this context, and in order to maximize the chance of a correct diagnosis, renal biopsy is mandatory to determine the exact nature of the lesion, and the severity of renal disease. Conclusion: It is important to make an early diagnosis of MGRS-associated C3 glomerulonephritis in order to prevent not only the progression to a hematological malignancy, but also end-stage renal disease.
Cultivation and expansion of mesenchymal stem cells from human gingival tissue and periodontal ligament in different culture media
Authors: Kusumawardani Banun , Robin Dwi Merry Christmarini , Puspitasari Endah , Savitri Irma Josefina , Suendi Dea Ajeng Pravita 
Published: April 2021

Background: Gingival tissue and periodontal ligament act as sources of mesenchymal stem cells (MSCs) that play a vital role in periodontal regeneration, but they both have limitations for cell availability. MSCs cultivated and expanded in various media formulations could be used as a basis for the development of cell therapy protocols. Purpose: This study aimed to determine the optimum culture media formulation for cultivation and expansion of human gingival-derived mesenchymal stem cells (hGMSCs) and human periodontal ligament stem cells (hPDLSCs). Methods: The hGMSCs and hPDLSCs were obtained from gingival tissue and periodontal ligament specimens from an adult patient. The two different culture media formulations used were: 1) α-minimum essential media (α-MEM) supplemented with 10% FBS, 100 U/mL penicillin, 100mg/mL streptomycin and 2.5 µg/mL amphotericin B; and 2) Dulbecco’s minimum essential media-Low Glucose (DMEM-LG) supplemented with 10% FBS, 2 mMol/L L-glutamine, 100 U/mL penicillin, 100mg/mL streptomycin and 2.5 µg/mL amphotericin B. The minced-gingival tissue and periodontal ligament samples were seeded in 3 cm tissue culture dishes with one of two experimental culture media, and incubated at 37oC in a humidified atmosphere of 5% CO2. Results: Cell morphology was observed on days two and five of the third passage. The gingival tissue and periodontal ligament primary cells exhibited fibroblast-like morphology, long processes and were spindle-shaped. The hPDLSCs grown in α-MEM exhibited a significant increase in cell viability and proliferation rate compared to the hPDLSCs grown in DMEM-LG. However, hGMSCs displayed similar cell viability and proliferation rate on both types of experimental media. Both the hGMSCs and hPDLSCs expressed MSC markers, including CD105, CD146, and CD90, but did not express CD45. Conclusion: Culture media formulations of α-MEM and DMEM-LG can be used for the cultivation and expansion of both hGMSCs and hPDLSCs.
PENGARUH PENGGUNAAN AMPAS TAHU TERFERMENTASI MENGGUNAKAN MIKROORGANISME MIX TERHADAP KINERJA PERTUMBUHAN JUVENIL UDANG VANAME (Litopenaeus vannamei)
Authors: Surianti S , Aslamyah A , Wahyudi W 
Published: April 2021

ABSTRACTThis study aims to determine the effect of the use of fermented tofu dregs using mix microorganisms on the growth of vaname shrimp (Litopenaeus vannamei). Test animals used in this study were 22-day-old vaname shrimp (PL 22) with an initial weight of ± 0.09 g. This study uses a completely randomized design (CRD) consisting of 4 treatments and 3 replications to obtain 12 experimental units, namely PA (5% fermented tofu waste) PB (10% fermented tofu waste) PC (15% fermented tofu waste) PD (20% fermented tofu pulp). The results showed that the treatment of various doses of fermented tofu dregs using Microorganism Mix significantly affected the growth rate and survival but did not affect the level of consumption of vaname shrimp feed. 15% fermented tofu pulp dosage is the best treatment for absolute growth, survival and consumption level of vaname shrimp feed Keywords: Tofu waste, mixed microorganisms, vaname shrimp, absolute growth, survival ABSTRAKPenelitian ini bertujuan untuk mengetahui pengaruh penggunaan ampas tahu terfermentasi menggunakan mikroorganisme mix terhadap pertumbuhan udang vaname (Litopenaeus vannamei). Hewan uji yang digunakan dalam penelitian ini adalah udang vaname umur 22 hari (PL 22) dengan bobot awal ± 0,09 g. Penelitian ini menggunakan rancangan acak lengkap (RAL) yang terdiri dari 4 perlakuan dan 3 kali ulangan sehingga diperoleh 12 unit percobaan, yakni PA (5 % ampas tahu terfermentasi) PB (10 % ampas tahu terfermentasi) PC (15 % ampas tahu terfermentasi) PD (20 % ampas tahu terfermentasi). Hasil penelitian menunjukkan perlakuan berbagai dosis ampas tahu terfermentasi menggunakan Mikroorganisme Mix berpengaruh nyata terhadap laju pertumbuhan dan sintasan tetapi tidak berpengaruh terhadap tingkat konsumsi pakan udang vaname. Dosis ampas tahu terfermentasi sebanyak 15% merupakan perlakuan terbaik untuk pertumbuhan mutlak, kelangsungan hidup dan tingkat konsumsi pakan udang vanameKata kunci : Ampas tahu, mikroorganisme mix, udang vaname, pertumbuhan mutlak, kelangsungan hidup
Modeling of MoS2 Tunnel Field Effect Transistor in Verilog-A for VLSI Circuit Design
Authors: Khan Md Azmot Ullah , Adesina Naheem Olakunle , Srivast Ashok , Xu Jian 
Published: April 2021

Abstract
This paper presents a newly designed physics-based analytical current transport model of both n- and p-type MoS2 tunnel field-effect transistor (TFET) using a high-level hardware language Verilog-Analog (Verilog-A) within Cadence/Spectre. The performance of our model is analysed by extracting different parameters, including transfer characteristics, power dissipation, and consumption, delay, power delay product (PDP) from the designed inverter. Moreover, we design a ring oscillator, and a half adder circuit to assess the compatibility of our model in both the analog and digital circuits. Our observation reveals that the voltage-controlled oscillator (VCO) can operate at a frequency of 31.6 GHz with a power consumption of 0.083 mW, and generates a phase noise of -122.5 dBc/Hz at 1MHz offset frequency. The simulated outputs (sum & carry) obtained from the half adder circuit exactly match the truth table of the circuit. Last, we present a comparison, using the performance parameters, of the ring oscillator with existing CMOS and GFET technologies. The results show that our designed VCO oscillates at a higher frequency with low power consumption and improved phase noise performance. With all the output characteristics obtained from the commercial software simulation, we expect our model to be applicable to a real-time low power VLSI circuit.
Regulation of Exosome Secretion by Cellular Retinoic Acid Binding Protein 1 Contributes to Systemic Anti-inflammation
Authors: Lin Yi-Wei , Nhieu Jennifer , Wei Chin-Wen , Lin Yu-Lung , Kagechika Hiroyuki , Wei Li-Na 
Published: April 2021

Abstract
Background: Intercellular communications are important for maintaining normal physiological processes. An important intercellular communication is mediated by the exchange of membrane-enclosed extracellular vesicles. Among various vesicles, exosomes can be detected in a wide variety of biological systems, but the regulation and biological implication of exosome secretion/uptake remains largely unclear.Methods: Cellular retinoic acid (RA) binding protein 1 (Crabp1) knockout (CKO) mice were used for in vivo studies. Extracellular exosomes were monitored in CKO mice and relevant cell cultures including embryonic stem cell (CJ7), macrophage (Raw 264.7) and hippocampal cell (HT22) using Western blot and flow cytometry. Receptor Interacting Protein 140 (RIP140) was depleted by Crispr/Cas9-mediated gene editing. Anti-inflammatory maker was analyzed using qRT-PCR. Clinical relevance was accessed by mining multiple clinical datasets. Results: This study uncovers Crabp1 as a negative regulator of exosome secretion from neurons. Specifically, RIP140, a pro-inflammatory regulator, can be transferred from neurons, via Crabp1-regulated exosome secretion, into macrophages to promote their inflammatory polarization. Consistently, CKO mice, defected in the negative control of exosome secretion, have significantly elevated RIP140-containing exosomes in their blood and cerebrospinal fluid, and exhibit an increased vulnerability to systemic inflammation. Clinical relevance of this pathway is supported by patients’ data of multiple inflammatory diseases. Further, the action of Crabp1 in regulating exosome secretion involves its ligand and is mediated by its downstream target, the MAPK signaling pathway.Conclusions: This study presents the first evidence for the regulation of exosome secretion, which mediates intercellular communication, by RA-Crabp1 signaling. This novel mechanism can contribute to the control of systemic inflammation by transferring an inflammatory regulator, RIP140, between cells. This represents a new mechanism of vitamin A action that can modulate the homeostasis of system-wide innate immunity without involving gene regulation.
Renewable Energies as a Substitute for Fossil Fuel Resources in Poland
Authors: Wasiuta Aleksander 
Published: April 2021

Abstract
BackgroundThe characteristic feature of modern energy sector in the EU is the development of environmentally friendly technologies based on renewable energy sources (RES). The use of alternative and RES contributes to resolving not only energy efficiency issues, but many of the environmental, economic and social problems. RES are also one of the priorities of the world's low carbon policy and reducing CO2 emissions into the atmosphere. Growing electrical energy consumption and increasing integration of RES in power systems have led to new challenges, thus it is required to investigate and properly analyze the impact of integrated RES on the power system as a substitute for fossil fuel resources.ResultsThe aim of the article is to show the possibilities of developing RES in Poland in the context of environmental protection, energy self-sufficiency and international obligations. The depletion of primary energy sources and the increase in emissions of greenhouse gases to the atmosphere forces undertaking certain activities, aimed at seeking substitutes for fossil fuels. According to the author’s analysis, RES are the best and safest substitutes for traditional energy resources such as fossil fuel.ConclusionsThe author examines electricity production mix in EU counties and compares it to Polish energy sector. Taking into consideration the transmission network density in Poland, while energy sector changes its structure and expands, the mix of technologies deployed to produce electricity determines the associated burden on transmission networks. Polish energy sector development in the context of modernization of transmission grid provides an opportunity for investors to prepare the energy system for increasing the share of renewable energy sources. In the process of implementing the appropriate solution, the experiences of other countries that have significantly increased the share of renewable energy in the past could be used. This article presents the main areas of action that may facilitate the further integration of different energy sources in the specific context of Poland's changing energy system. Not all integration options will be important for Poland at the same time.
Investigation for Safety of Final Quarry Bench During Mine Closure Stage – a Case Study
Authors: GOLDER AMIT , ROY INDRAJIT 
Published: April 2021

Abstract
The closure of opencast coal mining operation in Balanda mine will be a source of danger for inhabitants or any other infrastructure near the surface of ultimate quarry bench from safety point of view. In view of the above, MCL (Mahanadi Coalfield Limited) and the management of the Balanda opencast mine conducted a variety of design research and academic institutions to conduct a slope stability analysis of Balanda ocp (opencast project). It is also important here to note that the Birla Institute of Technology, Mesra, Ranchi, has prepared a study report on the above. This paper deals with design of ultimate quarry bench and discusses various geo-technical parameters for carrying out stability analysis.
Advancements of the examination of tool marks in human cartilage
Authors: Weber Matthias , Niehoff Anja , Rothschild Markus A. 
Published: April 2021

Abstract
This work deals with the examination of tool marks in human cartilage. We compared the effectiveness of several cleaning methods on cut marks in porcine cartilage. The method cleaning by multiple casts achieved the significantly highest scores (P = 0.02). Furthermore, we examined the grain-like elevations (dots) located on casts of cut cartilage. The results of this study suggest that the casting material forms these dots when penetrating cartilage cavities, which are areas where the strong collagen fibers leave space for the chondrocytes. We performed fixation experiments to avoid this, without success. In addition, 31 casting materials were compared regarding contrast under light-microscope and 3D tool marks scanner. Under the light-microscope, brown materials achieved significantly higher values than grey (P = 0.02) or black (P = 0.00) whereas under the 3D scanner, black materials reached higher contrast values than grey (P = 0.04) or brown (P = 0.047). To compare the accuracy and reproducibility of 6 test materials for cartilage, we used 10 knives to create cut marks that were subsequently scanned. During the alignment of the individual signals of each mark, the cross-correlation coefficients (Xmax) and lags (LXmax) were calculated. The signals of the marks in agarose were aligned with significantly fewer lags and achieved significantly higher cross-correlation coefficients compared to all tested materials (both P = 0.00). Moreover, we determined the cross-correlation coefficients (XC) for known-matches (KM) per material. Agarose achieved significantly higher values than AccuTrans®, Clear Ballistics™, and gelatine (all P = 0.00). The results of this work provide valuable insights for the forensic investigation of marks in human costal cartilage.
Cost Saving with Home-Based Chemotherapy Approach in Multiple Myeloma: The ADHOMY Trial
Authors: Schulmann Samantha , Achit Hamza , Filliatre-Clement Lauriane , Santolo Cécile Di , Ferry Marine , Vigneron Jean , Barbier-Lider Pauline , Morice Sophie , Campidelli Arnaud , Schirmer Luciane , Keddar Faiza , Ikhlef Souhila , Moulin Charline , Auge Helene , Ziegler Caroline , Feugier Pierre , Saunier Véronique , Guillemin Francis , Perrot Aurore 
Published: April 2021

Abstract
Bortezomib is a first-line therapy for multiple myeloma and also recommended in many associations for relapsing disease. Hospital-at-Home (HaH) is an attractive alternative to Outpatient Hospital (OH) treatment. The purpose of the study is to compare costs and patient-reported outcomes of two different strategies: exclusive OH-based bortezomib administration or combined administration in both OH and HaH. A prospective non-randomized trial was conducted in Nancy University Hospital. QoL was measured using the EuroQol 5D (EQ-5D) and the European Organization for Research and Treatment of Cancer (EORTC) QoL Questionnaire Core 30 (QLQ-C30). The analysis was conducted from the National Health Insurance System (NHIS) perspective. A total of 42 patients were enrolled in the study. Twenty patients received all bortezomib injections in OH (median of 24 injections) and 22 patients received bortezomib in OH alternately with HaH (median of 28.5 injections, 10.5 in OH and 18.0 in HaH). The average cost per injection was 602.63 € in the OH group versus 479.52 € in the OH/HaH group. Combined administration of bortezomib in OH and HaH was associated with a substantial cost-saving of 20.4% for NHIS and no difference in QoL. This trial responds to chronic patients’ wish to assess innovative ways of care.
Patient perceptions of physical rehabilitation education and treatment after breast cancer surgery: A mixed methods study
Authors: McGhee Deirdre E , McMahon Anne T , Steele Julie R 
Published: April 2021

Abstract
Purpose To investigate the content and delivery of physical rehabilitation education and treatment received by women following breast cancer surgery and to establish patient perceptions of this physical rehabilitation.Methods 509 Australian women (55 years SD 6.5) who previously had breast cancer surgery retrospectively completed an online survey about the content, delivery, satisfaction with and perceptions of the physical rehabilitation they received for six physical side-effects. The percentage of respondents who received each delivery format for the six physical side-effects and their satisfaction levels were tabulated. A thematic analysis was conducted on patients’ perceptions of the physical rehabilitation they received.Results Pamphlets were the most common delivery format of physical rehabilitation following breast cancer surgery. Common physical side-effects, however, were not included in the content and at less than 50% of women were satisfied with their physical rehabilitation. Three major themes emerged: Women perceived (i) they were unaware of and unprepared for the physical side-effects of their surgery/treatment, (ii) information delivery was unsuitable in terms of the timing, delivery format and cognisance of patient needs, and (iii) follow-up was insufficient at critical time points of recovery.Conclusion The physical rehabilitation received by women after all types of breast cancer surgery is perceived to be poor in terms of its content, delivery format and follow-up and women perceive that their needs at various stages of recovery are not being met. Physical rehabilitation needs to improve after all types of breast cancer surgery.
Survey On The application of Deep Learning in Internet of Things (IoT)
Authors: shadroo shabnam , Rahmani Amir Masoud , Rezaee Ali 
Published: April 2021

Abstract
The Internet of Things (IoT) is a network of physical instruments, software, sensors that all are connected to the Internet. The IoT produces massive data, where, this enormous volume of data allows the use of deep learning algorithms (DLAs). Recently, the increase of the large body of data and their availability has been one of the main reasons for paying attention to this issue. Further, the recent upgrade of the hardware boosting the computational power has resulted in the utilize of deep learning alongside the IoT. Therefore, the purpose of the present research is to review the relevant conference and journal articles in IoT and deep learning from 2012 to July 2019. To review the publications, a composition of Systematic Mapping and systematic literature review has been employed for creating a survey paper. Accordingly, some questions have been raised; to answer which, 32 articles have been investigated. The papers have been categorized into four sections including a focus on data, network, computing environment, application with each being examined, and analyzed. This article would be beneficial for researchers who want to investigate the field of deep learning and IoT.
Accumulation and Distribution of Rare Earth Elements (REEs) and Non-REEs With Vetiver Grass in The Abandoned Ion-Absorbed Rare Earth Mine
Authors: Kang Luhua , Cai Zhenfeng , Li Tiantian , Li Ping , Wang Liying 
Published: April 2021

Abstract
Overexploitation of rare earth elements (REEs) has caused serious desertification and environmental pollution, and ecological restoration of mines has attracted increasing national attention. In this paper, experiments involved land plowing, organic fertilizer broadcasting and vetiver cultivation were carried out to repair abandoned ion-absorbed rare earth mines (REM). Toxic metals content and pH in mining soil, distribution and transportation of toxic metals in the soil – vetiver grass system were investigated in detail.Results revealed that the abandoned REM soil was weakly acidic (pH=4.09) and rich in various toxic metals composed of REEs (La, Ce, Nd, Y, Gd, Dy) of 657.57mg/kg and Non-REEs (Pb, Cu, Se, As, Cd) of 109.98mg/kg. The distribution pattern in vetiver grass illustrated that toxic metals accumulation was mainly concentrated in the roots instead of shoot, and then the cumulative concentration of REEs in roots were much greater than that of Non-REEs. Furthermore, vetiver grass exhibited preferential accumulation of Cd, Se and REEs during the absorption process (from soil to root) and preferential accumulation of Pb, Cu and As during the translocation process (from root to leaf). The adsorption behavior of toxic metals by vetiver was confirmed due to these observed irregular particles in the scanning electron microscopy.
Trophic transfer, bioaccumulation and Health risk assessment of heavy metal in Aras river, Case study: Amphipoda- Zander - Human
Authors: Dehghani Amir , Aminjan Atabak Roohi , Dehghani Allaverdi 
Published: April 2021

Abstract
This research investigates and traces heavy metals (As, Pb, Cd and Cu) in a model of the aqueous food chain in the Aras River, located in northwestern of Iran. The selected model includes the zander (Sander lucioperca L.) and crustacean species known as amphipods (Gammarus spp.) that belong to the food chain of this fish. A total of 172 samples (70 fish and 102 Amphipoda) were collected randomly from the stations and analyzed for heavy metals using an Atomic Absorption Spectrophotometry (AAS). The results showed that the accumulation of heavy metals in both Taxon are in the order of As > Pb > Cd > Cu and concentrations of heavy metals in fish body are higher than Gammarus spp. in every stations in different seasons. Specimens of station (1) due to industrial activities indicates the highest heavy metal content. The concentrations of As, Pb, and Cd exceedes the permissible limits. There is a close correlation between the concentration of heavy metals in the amphipod and zander. The target hazard quotient (THQ), Total target hazard quotient (TTHQ) and Carcinogenic Risk (CR) were calculated to assess human health risk. The average of THQ for As (1.43) exceedes the international standards and will endangere the consumers of this fish species. The TTHQ for heavy metals has been estimated highr than 1. and at all stations, the value of CRCd > 1×10− 3, which reveals the degree of evidence of carcinogenicity of this metal in all parts of the Aras River. Therefore, according to results, effective controls and regular monitoring should be established in this regions