bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fifteen‐Year Trends in Incidence of Cardiogenic Shock Hospitalization and In‐Hospital Mortality in the United States
Authors: Osman Mohammed , Syed Moinuddin , Patibandla Saikrishna , Sulaiman Samian , Kheiri Babikir , Shah Mahek K. , Bianco Christopher , Balla Sudarshan , Patel Brijesh 
Published: July 2021

Background
There is a lack of contemporary data on cardiogenic shock (CS) in‐hospital mortality trends.

Methods and Results

Patients with CS admitted January 1, 2004 to December 31, 2018, were identified from the US National Inpatient Sample. We reported the crude and adjusted trends of in‐hospital mortality among the overall population and selected subgroups. Among a total of 563 949 644 hospitalizations during the period from January 1, 2004, to December 30, 2018, 1 254 358 (0.2%) were attributed to CS. There has been a steady increase in hospitalizations attributed to CS from 122 per 100 000 hospitalizations in 2004 to 408 per 100 000 hospitalizations in 2018 (
P
trend
<0.001). This was associated with a steady decline in the adjusted trends of in‐hospital mortality during the study period in the overall population (from 49% in 2004 to 37% in 2018;
P
trend
<0.001), among patients with acute myocardial infarction CS (from 43% in 2004 to 34% in 2018;
P
trend
<0.001), and among patients with non–acute myocardial infarction CS (from 52% in 2004 to 37% in 2018;
P
trend
<0.001). Consistent trends of reduced mortality were seen among women, men, different racial/ethnic groups, different US regions, and different hospital sizes, regardless of the hospital teaching status.

Conclusions
Hospitalizations attributed to CS have tripled in the period from January 2004 to December 2018. However, there has been a slow decline in CS in‐hospital mortality during the studied period. Further studies are necessary to determine if the recent adoption of treatment algorithms in treating patients with CS will further impact in‐hospital mortality.
Republic of Fakes: Art in the Service of Truth in Postwar France
Authors: Rönnbäck Fredrik 
Published: July 2021

Abstract
In 1955, Paris Police Commissioner Guy Isnard curated the exhibition Le Faux dans l'art et dans l'histoire at the Grand Palais in Paris. Featuring a wide variety of forgeries, most notably counterfeit sculptures and paintings, the exhibition was an occasion to showcase the anti-counterfeiting efforts of the National Police. But in the broader context of the politically and economically weakened Fourth Republic, more was at stake. In the immediate postwar period, French society was steeped in uncertainty and a growing fear of inauthenticity, fueled by rumors of currency manipulation by foreign powers, the perceived corruption of the French language by an increasingly influential English, and anti-Americanism in intellectual and political circles. In this environment, the organizers of the exhibition called upon culture, and art in particular, to reaffirm a strict distinction between truth and falsity while also establishing France as the uncontested guardian of truth. This essay shows that Le Faux dans l'art et dans l'histoire constituted a crucial threshold moment in twentieth-century French history, both as an attempt to preserve a rapidly fading vision of truth and originality and as a prefiguration of aesthetic and philosophical debates to come.
Speaking of Lotty Rosenfeld: “Gestures Dangerous, Simple, and Popular”
Authors: Brizuela Natalia , Bryan-Wilson Julia 
Published: July 2021

Abstract
This dialogue centers on the artwork and legacy of Chilean artist Lotty Rosenfeld, including such solo projects as One Mile of Crosses on the Pavement and her collaborations with CADA (Colectivo Acciones de Arte). It argues for a queer feminist reading of Rosenfeld as it considers her anti-dictatorship spatial practices, her intimacies with the writer Diamela Eltit, and her political and aesthetic commitments.
The relation of wind-driven coastal and offshore upwelling in the Benguela Upwelling System
Authors: Bordbar Mohammad Hadi , Mohrholz Volker , Schmidt Martin 
Published: July 2021

AbstractSpatial and temporal variations of nutrient-rich upwelled water across the major eastern boundary upwelling systems are primarily controlled by the surface wind with different, and sometimes contrasting, impacts on coastal upwelling systems driven by alongshore wind and offshore upwelling systems driven by the local wind-stress-curl. Here, concurrently measured wind-fields, satellite-derived Chlorophyll-a concentration along with a state-of-the-art ocean model simulation spanning 2008-2018 are used to investigate the connection between coastal and offshore physical drivers of the Benguela Upwelling System (BUS). Our results indicate that the spatial structure of long-term mean upwelling derived from Ekman theory and the numerical model are fairly consistent across the entire BUS and closely followed by the Chlorophyll-a pattern. The variability of the upwelling from the Ekman theory is proportionally diminished with offshore distance, whereas different and sometimes opposite structures are revealed in the model-derived upwelling. Our result suggests the presence of sub-mesoscale activity (i.e., filaments and eddies) across the entire BUS with a large modulating effect on the wind-stress-curl-driven upwelling off Lüderitz and Walvis Bay. In Kunene and Cape Frio upwelling cells, located in the northern sector of the BUS, the coastal upwelling and open-ocean upwelling frequently alternate each other, whereas they are modulated by the annual cycle and mostly in phase off Walvis Bay. Such a phase relationship appears to be strongly seasonally dependent off Lüderitz and across the southern BUS. Thus, our findings suggest this relationship is far more complex than currently thought and seems to be sensitive to climate changes with short- and far-reaching consequences for this vulnerable marine ecosystem.
Exploring the ‘Partial Connections’ between Growth and Degrowth Debates: Bhutan’s Policy of Gross National Happiness
Authors: Masaki Katsu 
Published: July 2021

Debates on degrowth have emerged with the realisation that the existing growth-oriented economic order has infringed upon our biosphere’s limits and human wellbeing. This must be rectified in favour of a more sustainable and equitable order through the promotion of green, caring and communal economies, as pointed out by degrowth advocates. However, these advocates argue for abandoning economic growth as a policy objective, thereby missing an opportunity to heed the potential of forging ‘partial connections’ between growth-seeking and degrowth-oriented measures. To explore a remedy against this pitfall, this study examines Bhutan’s policy of Gross National Happiness (GNH), which downplays a growth-for-growth’s sake approach but avoids precluding the pursuit of growth, in line with the historical unfolding of the country’s development plans and its Buddhism-based mores. Although GNH is yet to elicit a structural shift towards a full-fledged post-growth society, its balanced stance aids the search for a clue on how best to promote a post-growth transition with an intricate combination of growth-seeking and degrowth-oriented measures. Despite this potential, GNH has been largely overlooked by degrowth advocates, who depart from their own principle of valuing ‘locally determined paths’. JEL: B59, 029
Neuroimaging in Children Born With Congenital Zika Syndrome: A Cohort Study
Authors: Alves Lucas Victor , Hazin Adriano Nassri , Alves Joao Guilherme Bezerra 
Published: July 2021

Background and Purpose: Neuroimaging findings have been associated with adverse neurologic outcomes in children with congenital Zika virus infection. Our purpose is to describe the brain magnetic resonance imaging (MRI) of children around 3 years of age, born with congenital Zika syndrome. Methods: This cohort study followed 62 children born with congenital Zika syndrome who had head computed tomography (CT) performed during the first months of life. All these children had clinical, neuroimaging, and serological confirmation of congenital Zika. Around 3 years of age, these children received a brain MRI. Results: In 35 children, we could perform an MRI. All these children had severe impairment in neuromotor development. In general, the examinations showed the same alterations of the CT examinations: delayed myelination (82.8%), intracranial calcification (71.4%) although with decreased intensity and size as compared with previously CT examinations, ventriculomegaly (91.4%), cerebellar hypoplasia (68.5%), and cortical development abnormalities (85.8%). Conclusion: The serious brain alterations observed through head CT examinations in children born with congenital Zika syndrome continued to be detected through an MRI examination carried out at around 3 years of age. This indicates a poor prognosis for these children who had a severe neuromotor development delay.
Ethics review, reflective equilibrium and reflexivity
Authors: Morton Julie 
Published: July 2021

Background: Research Ethics Committees (RECs) or their equivalent review applications for prospective research with human participants. Reviewers use universally agreed principles i to make decisions about whether prospective health and social care research is ethical. Close attention to understanding how reviewers go about their decision-making work and consider principles in practice is limited. Objective: The study aimed to understand how reviewers made decisions in the contexts of meetings and to understand more about how reviewers approach their work. The purpose of this article is to draw on data and findings and to show how reflective equilibrium as a theoretical frame can (1) deepen understanding of ethics review and (2) permit a reflexive examination of the habitual processes of review. Design and participants: Methods captured the day-to-day work of the RECs. Seventeen applications were heard during eight observations. There were 12 formal interviews with reviewers (n = 12) and with researchers (n = 8) which are not reported on in this article. Ethical considerations: Organisational permission for the study was given by the National Research Ethics Service (NRES) whose functions became part of the Health Research Authority (HRA) during the study. The study was given favourable opinion by the University of Salford's REC (Reference HSCR11/17). Findings: Data were analysed using constructed grounded theory resulting in eight themes which revealed attention to procedure and engagement with applications. Reflective equilibrium was used as a qualitative frame to interpret themes distilling them into three processes at work in review: emotion and intuition; imagination and creative thinking; and intuition and trust. Discussion: Reviewers went back and forth between universal principles and considered these in the contexts of each application using the above processes. Conclusions: Reflective equilibrium offers a coherent and grounded account of review work. Reflexivity in training for reviewers is essential for improving practices. The challenges reflexivity presents can be assisted by using reflective equilibrium as a tool to illuminate tacit review processes.
Exchange Rate Uncertainty Effects on Domestic Investment in South Africa
Authors: Gidey Hiluf Techane , Nuru Naser Yenus 
Published: July 2021

The main goal of this study is to examine the effect of real effective exchange rate uncertainty on domestic investment for the South African economy over the sample period 1985Q1–2019Q2. To address this objective, Jordà’s (2005) local projection method is employed in this study. The generalised impulse response functions indicate that domestic investment decreases between the second and seventh quarters in response to one standard deviation shock in exchange rate uncertainty. Furthermore, high exchange rate uncertainty affects domestic investment negatively while low exchange rate uncertainty affects domestic investment positively. In other words, domestic investment declines due to a rise in exchange rate uncertainty while a drop in exchange rate uncertainty enhances domestic investment. Regarding the effects of control variables, output and export influences domestic investment positively and significantly. Inflation, however, has a negative and significant effect on domestic investment. Lastly, the Diks–Panchenko nonlinear Granger’s causality confirms bidirectional causality between exchange rate uncertainty and domestic investment. JEL Classification: C32, E22, F31, F41
The Adherence to Healthy Lifestyle Among Arab Patients With Cardiovascular Disease: Mixed-Method Review
Authors: Alomari Albara , Alananzeh Ibrahim , Lord Heidi , Fernandez Ritin 
Published: July 2021

Introduction Cardiovascular disease (CVD) accounts for 25% to 45% of deaths among Arab people. The purpose of this review was to investigate the level, predictors, motivators, and barriers to adherence to lifestyle recommendations among Arab patients with CVD. Method A systematic search of the literature was conducted and reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. MEDLINE, EMCARE, CINAHL, Scopus, and the Cochrane Central Register of Controlled Trials were searched. Studies that explored adherence to a healthy lifestyle among Arab adult patients with CVD were included. Results Twelve studies were included. Quantitative results showed low adherence among Arab people with CVD. Qualitative synthesized results revealed that internal motivators, personal desire as well as structural drivers impact the patient’s ability to adhere to a healthy lifestyle. Discussion Multidimensional solutions that consider religion and culture and include active involvement of families are required to improve adherence.
Prevalence of Injuries Among Medicaid Enrolled Infants Prior to Child Abuse and Neglect
Authors: Shanahan Meghan E. , Austin Anna E. , Berkoff Molly C. 
Published: July 2021

Prior research has identified common injuries among children who experience child maltreatment; however, most of this work has focused on inpatient settings and has excluded many cases of neglect. This study examines the prevalence of injuries that occur prior to a diagnosis of child maltreatment, as well as the proportion of children with well-child visits prior to the injury and child maltreatment diagnosis. Based on a secondary analysis of Medicaid data from four states, we found that among infants with 12 months of continuous enrollment ( N = 4817), 30.6% of those diagnosed with maltreatment were previously diagnosed with an injury. Among infants diagnosed with child maltreatment, 88.4% had at least one well-child visit prior to the maltreatment diagnosis. Among children with a maltreatment diagnosis and a prior injury, 84% had at least one well-child visit preceding the injury. These results indicate that most children had at least one well-child visit prior to being diagnosed with child maltreatment or an injury, indicating opportunities for prevention.
Ultra-low-dose radiation treatment for early-stage ocular adnexal MALT lymphoma
Authors: Lee Min Joung , Lee Me Yeon , Choe Ji-Young , Choi Se Hyun , Kim Hyo Jung 
Published: July 2021

Purpose: To investigate the long-term outcomes of ultra-low-dose (4 Gy) radiation treatment (RT) in patients with early-stage ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma. Methods: This retrospective case series includes eight patients with ocular adnexal MALT lymphoma who received ultra-low-dose RT at a single tertiary referral center between March 2016 and February 2018. Response to treatment and the time taken to respond were analyzed. Results: Of the eight patients (three men, five women), seven patients had conjunctival lymphoma (T1N0M0), and one patient had orbital lymphoma (T2N0M0). Six patients with T1 disease showed complete response (CR), and the median time to CR was 4.5 months (range 2–5). Partial response was achieved in the remaining two patients (one each with T1 and T2). During the median follow-up period of 44 months (range 30–54), none of the patients had a relapse or needed additional treatment. RT was well-tolerated in all patients with no ocular complications, including cataracts and dry eye. Conclusion: This case series suggests that ultra-low-dose RT is effective and well-tolerated in patients with early-stage ocular adnexal MALT lymphoma. Further studies with a larger sample size and long-term follow-up are needed to evaluate the local control rate and disease-free survival precisely.
Community risk perception and health-seeking behavior in the era of COVID-19 among adult residents of Harari regional state, eastern Ethiopia
Authors: Eyeberu Addis , Mengistu Dechasa Adare , Negash Belay , Alemu Addisu , Abate Degu , Raru Temam Beshir , Wayessa Alemayehu Deressa , Debela Adera , Bahiru Nebiyu , Heluf Helina , Kure Mohammed Abdurke , Abdu Ahmedmenewer , Dulo Amanuel Oljira , Bekele Habtamu , Bayu Kefelegn , Bogale Saron , Atnafe Genanaw , Assefa Tewodros , Belete Rabuma , Muzeyin Mohammed , Asmerom Haftu , Arkew Mesay , Mohammed Anumein , Asfaw Henock , Taddesse Barkot , Alemu Daniel , Yihun Dawit , Amare Shambel Nigussie , Kebira Jemal Yusuf , Adem Siraj Aliyi , Dirirsa Gebisa , Girmay Saba Hailu , Godana Abduro , Dechasa Deribe Bekele , Dessie Yadeta 
Published: July 2021

Background: COVID-19 brought significant challenges to public health. It changed the view of global health and safety, trust in the healthcare system, and clients’ willingness to seek healthcare. To contain the course of the COVID-19 pandemic and its detrimental effects, understanding peoples’ health behavior, especially healthcare-seeking, and determining the community risk perception is very important. Thus, this study aimed to determine the health-seeking behavior, community’s risk perception to COVID-19 pandemics, and factors influencing the community risk perception in Harari regional state, Ethiopia. Methods: Community-based cross-sectional study was conducted from 5 to 30 February 2021. A total of 1320 adult (>18 years) participants were selected using systematic random sampling. The data were collected using an online kobo collect toolbox and analyzed using descriptive statistical tests. Chi-square test and multiple binary logistic regression were applied to examine the difference between variables. A p-value < 0.05 was considered to be of statistical significance. Results: The study included 1296 respondents >18 years old. The overall prevalence of willingness to seek healthcare in the study area was 35.6% (95% CI: 33%–38.3.0%). The mean cumulative score of risk perception was 30.5 (SD ± 7.25) with the minimum and maximum score of 13 and 63, respectively. A total of 656 (50.6%) of the participants had low-risk perceptions concerning COVID-19. The study found a statistically significant association between risk perception and sociodemographic characteristics (age, educational status, and income), and knowledge of the respondents. Conclusion: The overall prevalence of willingness to seek healthcare was 35.6%. Healthcare intervention aimed to contain the COVID-19 pandemic should consider the factors associated with the study area. Similarly, the study found a low-risk perception among the community that needs critical action to manage the COVID-19 pandemic and to protect the community as a whole. Thus, it is necessary to improve community risk perception through health education.
CEBPA mutations in 4708 patients with acute myeloid leukemia: differential impact of bZIP and TAD mutations on outcome
Authors: Taube Franziska , Georgi Julia Annabell , Kramer Michael , Stasik Sebastian , Middeke Jan Moritz , Röllig Christoph , Krug Utz , Krämer Alwin , Scholl Sebastian , Hochhaus Andreas , Brümmendorf Tim H. , Naumann Ralph , Petzold Andreas , Mulet-Lazaro Roger , Valk Peter J. M. , Steffen Björn , Einsele Hermann , Schaich Markus , Burchert Andreas , Neubauer Andreas , Schäfer-Eckart Kerstin , Schliemann Christoph , Krause Stefan W. , Hänel Mathias , Noppeney Richard , Kaiser Ulrich , Baldus Claudia D. , Kaufmann Martin , Herold Sylvia , Stölzel Friedrich , Sockel Katja , von Bonin Malte , Müller-Tidow Carsten , Platzbecker Uwe , Berdel Wolfgang E. , Serve Hubert , Ehninger Gerhard , Bornhäuser Martin , Schetelig Johannes , Thiede Christian ,   for the Study Alliance Leukemia (SAL)
Published: July 2021

Abstract
Biallelic mutations of the CEBPA gene (CEBPAbi) define a distinct entity associated with favorable prognosis; however, the role of monoallelic mutations (CEBPAsm) is poorly understood. We retrospectively analyzed 4708 adults with acute myeloid leukemia (AML) who had been recruited into the Study Alliance Leukemia trials, to investigate the prognostic impact of CEBPAsm. CEBPA mutations were identified in 240 patients (5.1%): 131 CEBPAbi and 109 CEBPAsm (60 affecting the N-terminal transactivation domains [CEBPAsmTAD] and 49 the C-terminal DNA-binding or basic leucine zipper region [CEBPAsmbZIP]). Interestingly, patients carrying CEBPAbi or CEBPAsmbZIP shared several clinical factors: they were significantly younger (median, 46 and 50 years, respectively) and had higher white blood cell (WBC) counts at diagnosis (median, 23.7 × 109/L and 35.7 × 109/L) than patients with CEBPAsmTAD (median age, 63 years, median WBC 13.1 × 109/L; P &lt; .001). Co-mutations were similar in both groups: GATA2 mutations (35.1% CEBPAbi; 36.7% CEBPAsmbZIP vs 6.7% CEBPAsmTAD; P &lt; .001) or NPM1 mutations (3.1% CEBPAbi; 8.2% CEBPAsmbZIP vs 38.3% CEBPAsmTAD; P &lt; .001). CEBPAbi and CEBPAsmbZIP, but not CEBPAsmTAD were associated with significantly improved overall (OS; median 103 and 63 vs 13 months) and event-free survival (EFS; median, 20.7 and 17.1 months vs 5.7 months), in univariate and multivariable analyses. Additional analyses revealed that the clinical and molecular features as well as the favorable survival were confined to patients with in-frame mutations in bZIP (CEBPAbZIP-inf). When patients were classified according to CEBPAbZIP-inf and CEBPAother (including CEBPAsmTAD and non-CEBPAbZIP-inf), only patients bearing CEBPAbZIP-inf showed superior complete remission rates and the longest median OS and EFS, arguing for a previously undefined prognostic role of this type of mutation.
CACNA1A-p.Thr501Met mutation associated with familial hemiplegic migraine: a family report
Authors: Romozzi Marina , Primiano Guido , Rollo Eleonora , Travaglini Lorena , Calabresi Paolo , Servidei Serenella , Vollono Catello 
Published: July 2021

Abstract
Background and aims
Hemiplegic migraine (HM) is a rare form of migraine characterized by the presence of a motor and other types of aura. HM can be sporadic or familial. Familial hemiplegic migraine (FHM) is an autosomal dominant disorder, classified into 3 subtypes, based on the gene involved (CACNA1A in FHM1, ATP1A2 in FHM2 and SCN1A in FHM3). The clinical presentation is highly heterogeneous and some attacks may be severe.
We report the clinical characteristics and genetic analysis of 12 patients belonging to a family with CACNA1A-p.Thr501Met gene mutation.

Methods
We screened for mutations in CACNA1A gene 15 patients belonging to the same family. The exonic sequences of CACNA1A were analyzed using a Tru-seq® Custom Amplicon (TSCA) (Illumina Inc., San Diego, CA) targeted capture and paired end library kit. Sanger sequencing was used to confirm CACNA1A variants and segregation analysis.

Results
CACNA1A-p.Thr501Met mutation was found in 12 of the 15 patients screened, which was compatible with the diagnosis of FHM1.
Attacks of hemiplegic migraine were reported by 10 of the 12 subjects (83.33%). Only one subject developed persistent mild cerebellar symptoms and none of the subjects developed cerebellar atrophy.

Discussion
The variant p.Thr501Met was described previously in association with episodic ataxia and rarely with FHM related to cerebellar symptoms. FHM1 has a broad clinical spectrum and about half of the families have cerebellar involvement. In our study, only one patient developed persistent cerebellar deficits.
These data suggest that CACNA1A-p.Thr501Met mutation can occur prevalently as hemiplegic migraine.