bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microangiopathic antiphospholipid syndrome (MAPS) in the course of undifferentiated connective tissue disease
Authors: Targońska-Stępniak Bożena , Wielosz Ewa , Majdan Maria 
Published: March 2021

Introduction. The microangiopathic antiphospholipid syndrome (MAPS) is a subset of APS comprising those patients presenting with thrombotic microangiopathy and demonstrable antiphospholipid antibodies. Renal involvement occurs frequently in the course of MAPS with clinical symptoms of acute renal failure, hypertension, proteinuria and erythrocyturia. Case report. The report presents the patient with MAPS confirmed by kidney biopsy in the course of undifferentiated connective tissue disease.Conclusion. The authors emphasize the importance of effective anticoagulant treatment in order to inhibit thrombosis and renal damage in the course of MAPS.
Prospective observational study on predicting adverse clinical outcomes in patients with implanted defibrillating devices – a study rationale, design and principal methods
Authors: Guzik Przemysław , Piskorski Jarosław , Wysocki Henryk , Wykrętowicz Andrzej 
Published: March 2021

The project “Predicting adverse clinical outcomes in patients with implanted defibrillating devices” is a prospective observational study in a group of high risk cardiac patients with already implanted either an implantable cardioverter-defibrillator (ICD) or a cardiac resynchronization therapy device with defibrillating mode (CRT-D). The primary project aim is to build predictive models for an appropriate ICD or CRT-D interventions and other adverse clinical outcomes based on clinical assessment of the cardiovascular system, general clinical status, advanced mathematical and statistical analysis of cardiovascular time series and biological signals, including pressure waveforms, ECG and cardiac impedance. Up to 600 ambulatory adult patients are scheduled to be enrolled and after the first visit they are expected to be followed-up every 6 months for a number of clinical outcomes, including antiarrhythmic therapy intervention, sudden and aborted cardiac death and total mortality. The project launched in March 2010 and is expected to end in February 2014.
A survey on instantaneous data transmission in Wireless Sensor Networks for Healthcare Monitoring
Authors: JT THIRUKRISHNA , V Aishwarya M , Singh Mansi , B Mounisha , Kaveri Naksha 
Published: March 2021

Abstract
Real time health monitoring using WSN of imbed and wearable sensors is visualized as a continual monitoring solution of bedridden outpatient with motility. This paper aims to implement an instantaneous patient monitoring framework, which is proficient in collecting, transmitting and monitoring patient’s perceptual conditions. In present Health monitoring frameworks, the patients are supervised by medical professionals using various equipment’s which are hardwired to nearby bedside monitors or PCs, and essentially this equipment’s are substantial and consequently it keeps patients confine to bed. The drawbacks of these frameworks may affect the patient’s mobility during monitoring the vital signs. Our proposed real time health monitoring framework can detect patient’s health conditions like pulse rate, body temperature and electrocardiograph using different bio sensors, the collected data will be processed using ARM7LPC2148 and the processed data is efficiently transferred wirelessly to LabVIEW software via ZigBee. In case of abnormalities, the SMS will be sent to doctor’s/care givers using GSM. In addition, the proposed framework uses ZigBee technology since it is low cost and achieves low power usage to maximize the network lifetime, accelerate and expand transmission protocols and also battery life is significantly improved. This framework will help patients to recover easily and also provides enhanced medical care to patients at a low cost. Furthermore, the framework provides profitable benefits for virtually monitoring individuals living away from the remote areas, old individuals, heart patients and can be used for COVID-19 patients in home and hospitals thereby improving medical administrations.
Optimal Shortest Path Selection Base on Multi-Criteria Decision Making in Vehicular Ad Hoc Network
Authors: Shah Akmal , Hussain Tariq , Ali Iqtidar 
Published: March 2021

Abstract
Vehicular Ad-hoc Network (VANET) is the subtype of Mobile Ad-hoc Network (MANET) where every node is represented as the vehicle. Although, VANETs and MANETs have some common properties still have a difference in their properties and behaviors i.e. nodes of VANETs have unlimited resources in terms of energy, memory, and computational power. Advanced traffic management a vital role in maintaining the flow of traffic, using the latest technologies such as Intelligent Transport System (ITS). The congestion and best Optimal path selection are among the most prominent research issues in VANETs. Different researchers have worked on it and most of them such as Frictional Glow-Warm Swarm Optimization (FGWSO) and Stable CDS-Based Routing Protocol (SCRP) have solved the issue of best-path selection using shortest paths. In this research, we are selecting an optimal shortest path from all available paths through using Analytical Network Process (ANP) analysis and Multi-criteria Decision Making (MCDM) approach. The performance of the proposed Optimal Shortest Path Selection (OSPS) scheme for VANET is being evaluated by super decision-making tool. The parameters such as average speed, end to end delay, shortest path selection, Distance are compared pairwise with each other. The results are derived and shown through the limit matrix by taking four scenarios. These four scenarios are labeled by nodes B, O, K, and node Y, which are optimal nodes respectively, having the highest priority weight. The results show that the proposed OSPS scheme has minimized the end-to-end delay as compared to FGWSO and SCRP schemes.
Application of Mining Algorithm in Personalized Internet Marketing Strategy in Massive Data Environment
Authors: Peng Zhiba 
Published: March 2021

Abstract
Internet marketing requires a personalized marketing strategy. In this study, the application of data mining in personalized Internet marketing was studied. Based on the mining algorithm, a personalized marketing method was designed. Through the calculation of frequent closed item sets and support counts of positive and negative samples, the interval with a high success rate for marketing was obtained. With performance analysis, it was found that the marketing method of this study successfully improved the rate about 8% compared with the traditional marketing method. This method would have better performance under the smaller interval number and smaller minimum success number. After the actual application in telecommunication enterprise A, it was found that after adopting the marketing method of this study, the marketing success rate of A enterprise increased from 2.72–6.31%, which indicated the effectiveness of the method. The research results in this study proved the role of data mining algorithms in Internet marketing, which was conducive to the further application of mining algorithms in personalized marketing.
Flexible Cellulose-Based Assembled with PEDOT: PSS Electrodes for ECG Monitoring
Authors: Wang Yanping , Zhong Xing , Wang Wei , Yu Dan 
Published: March 2021

Abstract
Electrocardiography is one of the most significant technologies for detecting cardiovascular diseases. Nowadays, the problems of various electrodes still meet a great challenge. Herein, we design a low cost, environmentally friendly and flexible conductive electrode using cellulose and polyvinyl alcohol as a substrate assembled with conductive polymer polythiophene by in-situ oxidative polymerization, and the green solvent 1-butyl-3-methylimidazolium chloride as a crosslinking agent. The polyvinyl alcohol/cellulose/PEDOT:PSS(PCPP) composite electrode has excellent features of flexibility, low skin contact impedance and comfortable contact with skin. When the load of EDOT reaches 15 wt%, the electrode is stable and can clearly monitor the characteristic wave of ECG signals. Therefore, based on cellulosic biopolymer and conductive polymer PEDOT:PSS, an environmentally friendly, flexible and stable PCPP composite electrode is obtained and can be a promising candidate applied in the fields of energy storage and ECG sensing.
Effects of Muscle Energy Technique in Patients with Tension Type Headache; A Randomized Control Clnicial Trial
Authors: Sohail Rabia , Riaz Huma , Akhtar Muhammad , Raza Asim , Shabbir Kinza , Ahmad Ashfaq 
Published: March 2021

Abstract
Background: Tension type headache is claimed to be one of top ten disabling conditions in the world. The purpose of the study was to determine the effects of muscle energy technique on pain, range of motion at cervical spine and disability related to tension type headache. Methods: A randomized control trial was conducted on 48 participants of both genders whose age was 18 to 40 years with complain of tension type at Rehabilitation and Injury Management Department of Medcare International Hospital Gujranwala, from July to December 2019. Participants were randomly selected and allocated into two groups (experimental and control group). The experimental group received both muscle energy technique and myofascial release technique on trapezius and sternocleidomastoid of both sides. The intervention was applied for 6 weeks (3 sessions per week). Assessments were done at baseline, 4th week and 6th week. Numeric pain rating scale (NPRS), Headache disability inventory (HDI), headache impact test (HIT) and cervical range of motion with the help of Inclinometer were tools for assessment. Data analysis was done using SPSS (version 21). Results: The mean age of experimental group was 26.5±5.42 and control group was 27.7±5.70. The experimental group was shown significant improvement in terms of pain and flexion and side flexion range of motion with p-value ≤0.05. Conclusion: It is concluded that muscle energy technique is effective treatment for tension type headache; it is associated to decreased range of motion at cervical spine and disability related to TTH. Trial registration: IRCT20190121042445N2, Registered 07-02-2021.
The role of app-based remote patient monitoring in reducing primary care clinician workload during the COVID pandemic: A prospective observational real world feasibility study.
Authors: Shah Sachin Shailendra , Safa Afsana , Johal Kuldhir , Obika Dillon , Valenine Sophie 
Published: March 2021

Abstract
Background COVID-19 has placed unprecedented strain on healthcare providers, in particular, primary care services. GP practices have to effectively manage patients remotely preserving social distancing. We aim to assess an app-based remote patient monitoring solution in reducing the workload of a clinician. Primary care COVID patients in West London deemed medium risk where recruited into the virtual ward. Patients were monitored for 14 days by telephone or by both the Huma app and telephone. Information on number of phone calls, duration of phone calls and duration of time spent reviewing the app data recorded.Results The amount of time spent reviewing one patient on the telephone only arm of the study was 490 minutes, compared with 280 minutes spent reviewing one patient who was monitored via both the Huma app and telephone. Based on employed clinicians monitoring patients, this equates to a 0.04 reduction of full-time equivalent staffing I.e. for every 100 patients, it would require 4 less personal to remotely monitor them. There was no difference in mortality or adverse events between the two groups.Conclusion App-based remote patient monitoring clearly holds large economic benefit to COVID-19 patients. In wake of further waves or future pandemics, and even in routine care, app-based remote monitoring patients could free up vital resources in terms of clinical team’s time, allowing a better reallocation of services.
Integrated gene expression profiling reveals potential immune-related biomarkers for rheumatoid arthritis
Authors: Ye Tong , Haoyuan Zhou , Peng Zhao , Haidong Xu 
Published: March 2021

Abstract
Background As one of the most common causes of joint deformities, rheumatoid arthritis (RA) has seriously affected human health. In this study, RA biomarkers related to immunity were identified by bioinformatics methods. Methods RA synovial microarray data were obtained from GEO database and preprocessed, and then differentially expressed genes(DEGs) were screened. Subsequently, the hub nodes were screened from the PPI network of DEGs by STRING database and cytoscape software. The hub nodes were verified in independent dataset. The immune infiltration in synovial tissue of RA was analyzed by CIBERSORT algorithm. In addition, the correlation between differentially infiltrated immune cells and key genes was analyzed. Results Intersected DEGs were significantly enriched in biological processes, including immune response − activating signal transduction, B cell activation, T cell activation. Through PPI network and immune infiltration analysis, we finally identified 5 immune-related biomarkers including CCL5, CCR5, CD27, CXCL9 and TLR8. Conclusion CCL5, CCR5, CD27, CXCL9 and TLR8 may be potential diagnostic biomarkers for RA treatment strategies.
The effectiveness of group counseling based on problem- solving solution on sexual function and sexual satisfaction of women after mastectomy surgery
Authors: Bokaie Mahshid , Firouzabadi Ommolbanin , Joulaee Azadeh 
Published: March 2021

Abstract
Background: Breast cancer is the second cause of death due to cancers and it is the most common cancer in women, which threatens different aspects of individual and mental health, quality of life, sexual function and sexual satisfaction, because of such treatments as mastectomy. Consultation can help patients to and a reasonable solution for their problems. Considering the effect of consultation on quality and quantity of patients’ life and the importance of the role of midwife in sexual health consultation, this research is carried out in order to determine the effect of group consultation based on problem-solving solution on sexual function and satisfaction of women who have had mastectomy surgery. Method: The present research is a semi-empirical study, with pretest, post-test and one month follow-up period. 32 women who referred to Tehran Breast Cancer Institute were selected by convenience sampling.The group received 8 sessions (90-minute) of problem-solving solution conselling. The data collection tool was Female Sexual function Index and Larson sexual satisfaction questionnaires and filled before intervention, immediately after intervention and one month after it.Data analysis was performed by using SPPSS21 statistical software application at the certainty level of 95% (P≤0.05).Results: The results of the study showed that there is a meaningful difference between the average sexual function (18.37, 20.88, 22.95) and the sexual satisfaction (65.27, 68.08, 70.46) in three stages before the intervention, immediately after the intervention and one month after the intervention. Conclusions: Although the average score of women’s sexual performance and the average score of sexual function of women who had mastectomy operation have improved, and this change was significant, but we have to note that the sexual function and sexual satisfaction are still in an inappropriate situation which require the continued trend of counseling in these patients. Considering the fact that the outbreak of breast cancer is very high, counseling can transfer to patients the information that is necessary for creating a desirable sexual life. In addition, through counseling process, we can teach patients how to live with their disease.
Isolation and Identification of Staphylococcus Aureus from Dairy Farms in Bishoftu Town, Ethiopia
Authors: Bude Sara Amanuel , Mengesha Abdi Kidane 
Published: March 2021

Abstract
A cross-sectional study was conducted from February, 2020 to March, 2020 in selected dairy farms in Bishoftu Town to isolate and identify Staphylococcus aureus from milk samples, swab (teat swab, tank swab and bucket swab) samples. The samples were transported to microbiology laboratory and, isolation and identification of an organism was based on morphological, cultural and biochemical characteristics. Accordingly a total of 120 samples of them 58 milk sample, 58 polled teat swab sample, 2 polled tank swab sample and 2 polled bucket swab samples. Those milk samples and swab sample were collected and cultured parallel on both Blood agar and nutrient agar. Out of total samples 68/120 were well grown on both Medias and sub cultured on nutrient agar for farther identification using Primary and secondary biochemical tests. Accordingly, 68 milk samples were shown typical large, round, golden yellow colonies with hemolysis when grown on blood agar, round shaped grape like clusters are seen under microscope after stained with grams stain, and catalase positive Staphylococcus aureus with bubble formation is observed and typical yellow pigmentation on mannitol salt agar which is selective media for genus Staphylococcus. Finally, 68(56.67%) Staphylococcus aureus were identified with coagulase test with the clumping result observed. Hence, implementing hygiene conditions, creation of awareness on control and prevention of subclinical mastitis in dairy farms and conducting drug sensitivity test for Staphylococcus aureus is recommended.
The Effect of Jigsaw Technique on Iranian Intermediate Learners’ Reading Anxiety
Authors: Bijani Houman , Hashempour Bahareh 
Published: March 2021

Abstract
Student anxiety is a considered as an impediment in learning development and in particular language acquisition. Anxious students generally refuse to take part in group and pair-work activities. Accordingly, their passive behavior is a shortcoming to pedagogical cooperation and development. The present study investigated the effect of Jigsaw Technique on reading anxiety of English as a Foreign Language) EFL intermediate Iranian learners. To this end, among 157 participants 60 intermediate learners were chosen randomly based on the Oxford Quick Placement Test (OQPT) and were instructed by the employment of Jigsaw Technique. The results of the EFL Reading Anxiety Inventory (EFLRAI) questionnaire indicated that the learners’ reading anxiety considerably decreased after the treatment. Moreover, the results revealed that the employment of Jigsaw Technique were more effective than before the treatment. The findings of the study proved the usefulness of Jigsaw Technique in promoting learners’ cooperative learning, their self-confidence, as well as reducing their anxiety and creating a stress-free environment. The findings of the study have great contribution in creating pedagogical materials for learners as they can facilitate instruction and maximize comprehension accordingly.
High data rate and ultra-compact optical encoder based on 2D linear photonic crystal ring resonator
Authors: Chhipa Mayur Kumar , Madhav B.T.P. , Suthar Bhuvneshwer , Janyani Vijay 
Published: March 2021

Abstract
In the present work, a high-speed optical encoder is proposed based on two-dimensional photonic crystal ring resonator (2D-PCRR) using coupled mode theory and resonance effect. Square shaped ring resonator, couplings rods and several waveguides have been utilized in the proposed structure. Silicon rods in air structure has been designed with rod radius of 0.1a and lattice constant 0.540 nm. The photonic band gap is being calculated using plane wave expansion method and finite-difference-time-domain method to analyze the performance characteristics of optical encoder like: transmission spectra, electric field view, contrast ratio, delay time, response time etc. The operating wavelength of structure is 1550 nm, to perform encoder operation where only one input port is activated at a time while other input ports are inactivated and accordingly equivalent binary encoded signal is produced at output ports. The proposed encoder is designed with fast response time 222.76 fs, high data rate of 4.48 Tbps and ultra-compact size of 140.84µm2. Hence the proposed device is suitable for high-speed optical computation, photonic integrated devices and high speed optical integrated circuits.
Nature of a Long Carbon–Carbon Bond Beyond 2.0 Å
Authors: Kubo Takashi , Suga Yuki , Hashizume Daisuke , Suzuki Hiroki , Miyamoto Tatsuya , Okamoto Hiroshi , Kishi Ryohei , Nakano Masayoshi 
Published: March 2021

Abstract
Elongating carbon–carbon (C–C) single bonds is challenging in terms of molecular design and synthesis, and in understanding the nature of the long bonds. Herein, we demonstrate that a C–C bond longer than 2.0 Å can be realised by face-to-face interactions between fluorenyl rings. A small orbital overlap between the distantly positioned carbon atoms is observed as a small concentration of electrons on the X-ray electron density maps. The highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) of the compound originate from the in-phase and out-of-phase interactions of the overlapping orbitals, respectively, with a gap of 2.39 eV. Solid-state 13C NMR spectroscopy shows a sharp peak at 82.9 ppm for the long-bonded carbons, while a CASSCF(6,6) calculation indicates a small diradical character. The experimental and theoretical analyses reveal a sufficient covalent bonding character in the long C–C bond.
Imperatorin alleviated NLRP3 inflammasome cascade-induced synovial fibrosis and synovitis in rats with knee osteoarthritis
Authors: Zhang Haosheng , Ding Liang , Shi Xiaoqing , Mei Wei , Huang Zhengquan , Zhang Li , Li Xiaochen , Zhang Li , Wang Peimin 
Published: March 2021

Abstract
Background: To clarify the therapeutic potential of imperatorin (IMP) in knee osteoarthritis (KOA).Methods: Thirty 3-month-old SD male rats were randomly divided into Normal group, monosodium iodoacetate (MIA) group and MIA+IMP group. Their synovial tissues were subjected to histopathological analysis. Primary synovial fibroblasts obtained from additional normal rats were treated by lipopolysaccharide (LPS) and then IMP. The mRNA and protein expressions of factors related to synovitis and synovial fibrosis were detected by qRT-PCR and Western blotting, respectively. The levels of inflammatory factors IL-1β and IL-18 were measured by ELISA.Results: IMP reduced HIF-1α, NLRP3 inflammasome expression and IL-1β, IL-18 production in synovial fibroblasts induced by LPS. IMP also down-regulated synovial fibrosis markers. In vitro study revealed that MIA-induced synovitis and synovial fibrosis were relieved by IMP.Conclusion: IMP exerts anti-inflammatory effects associated with synovitis and synovial fibrosis. It reduces the production of pro-inflammatory mediators and cytokines and inhibits TGF-β1, TIMP-1 and VEGF expressions that promote synovial fibrosis.