bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetically Predicted Cardiac Troponin I Concentrations and Risk of Stroke and Atrial Fibrillation
Authors: Liu Dandan , Deng Yue , Wang Jiao , Chen Yanan , Yu Jian , Tan Boyu , Wang Mengmeng 
Published: July 2021

Abstract
Background: Observational studies have shown that elevated circulating cardiac troponin I (cTnI) concentrations were associated with higher risk of stroke and atrial fibrillation, but the causality remains unclear. Therefore, we conducted a two-sample mendelian randomization study to evaluate the causal effects of cTnI concentrations on the risk of stroke subtypes and atrial fibrillation.Methods: The instrumental variables for circulating cTnI concentrations were selected from a genome-wide association study meta-analysis of 48,115 European individuals. Applying a 2-sample mendelian randomization approach, we examined the associations of circulating cTnI concentrations with stroke (40,585 cases and 406,111 controls), ischemic stroke (34,217 cases and 406,111 controls), ischemic stroke subtypes (cardioembolic, large artery, small vessel stroke), intracerebral hemorrhage (1,545 cases and 1,481 controls) and atrial fibrillation (60,620 cases and 970,216 controls). Results: Genetically predicted elevated circulating cTnI concentrations were associated with increased risk of cardioembolic stroke (odds ratio [OR], 1.80; 95% confidence interval [CI], 1.20-2.68; P = 0.004). However, no significant association was observed for cTnI concentrations with large artery stroke, small vessel stroke, total stroke, ischemic stroke and intracerebral hemorrhage. Additionally, we also found that elevated cTnI concentrations were associated with higher risk of atrial fibrillation (OR, 1.30; 95% CI, 1.10-1.53; P = 0.003).Conclusions: This study provides evidence that genetically predicted circulating cTnI concentrations are causally associated with increased risk of cardioembolic stroke and atrial fibrillation.
Chemical characterizations of Neurotransmission Receptors of human and plant to unfold the evolutionary relationships among them
Authors: SENGUPTA ANTARA , CHAKRABORTY SUBHADIP , CHOUDHURY PABITRA PAL 
Published: July 2021

Abstract
Vertebrates have very well defined nervous system. It is established that plant also has an alternative sort of sensitive nervous system. Researchers find a close relationship of the neurotransmission mechanism of animal with the plant and suspects close relation in amino acid transport mechanism among both the organisms. Along with the abilities of determining protein structure and various functions, the chemical properties of amino acids also have great contribution in molecular evolution. Hence, in this present work it is aimed at making comparative study on the distribution of amino acids in the neurotransmission receptors associated to animals and plants, based on the chemical properties the amino acids contain. It is possible to classify 20 amino acids into 8 chemical groups and are identified by specific numeric value. The common pattern finding procedure in numerical representation of protein sequences find some conserved regions in the receptor protein sequences of both the species. The comparative study has been made on distributions of chemical properties in protein sequences of ionotropic glutamate receptor protein sequences and GABA receptor protein sequences of two species namely human, a vertebrate and Arabidopsis thaliana, a plant. Experiments have been carried out to calculate proximity between protein sequences based on the distribution of each chemical group (in percentage) in them and phylogenetic trees have been constructed to find evolutionary relationships of neurotransmission receptors of both the spices.
Polarization of rheumatoid macrophages is regulated by the CDKN2B-AS1/ MIR497/TXNIP axis
Authors: Xu JianZhong 
Published: July 2021

Abstract
The polarization of macrophages plays a critical role in the pathophysiology of rheumatoid arthritis. The polarization states include pro-inflammatory M1 polarization and various alternative anti-inflammatory M2 polarization. Our preliminary results showed that CDKN2B-AS1/MIR497/TXNIP axis might play a role in macrophages extracted from rheumatoid arthritis patients. Therefore, we proposed that this axis regulated the polarization of rheumatoid macrophages. Flow cytometry was used to determine the surface polarization markers in M1 or M2 macrophages from healthy donors and rheumatoid arthritis patients. QPCR and western blotting were used to compare the expression of CDKN2B-AS1/MIR497/TXNIP axis in these macrophages. We interfered with the expression and function of the CDKN2B-AS1/ MIR497/TXNIP axis from upstream to downstream in the macrophage cell line MD to test its roles in macrophage polarization. Compared to cells from healthy donors, cells from rheumatoid arthritis patients expressed a higher level of CD40 and CD80 and a lower level of CD16, CD163, CD206, and CD200R after polarization, they also expressed higher CDKN2B-AS1, lower MIR497, and higher TXNIP. In macrophages from healthy donors, there was no correlation among CDKN2B-AS1, MIR497, and TXNIP. But in macrophages patients, they showed significant correlations. The CDKN2B-AS1 knockdown, MIR497 mimics suppressed M1 polarization but promoted M2 polarization in MD cells, while MIR497 knockdown and TXNIP overexpression did the opposite. Elevated CDKN2B-AS1 in macrophages promotes M1 polarization and inhibits M2 polarization of macrophage by negative regulating MIR497, thereby upregulated the expression of TXNIP.
The CDKN2B-AS1/ MIR497/TXNIP axis regulated macrophages
Authors: Xu Jianzhong , Li Yu , Gu Chenxi , Liu Guanlei , Yu Yang 
Published: July 2021

Abstract
Abstract

The polarization of macrophages plays a critical role in the pathophysiology of rheumatoid arthritis. The polarization states include pro-inflammatory M1 polarization and various alternative anti-inflammatory M2 polarization. Our preliminary results showed that CDKN2B-AS1/MIR497/TXNIP axis might play a role in macrophages extracted from rheumatoid arthritis patients. Therefore, we hypothesized that this axis regulated the polarization of rheumatoid macrophages. Flow cytometry was used to determine the surface polarization markers in M1 or M2 macrophages from healthy donors and rheumatoid arthritis patients. QPCR and western blotting were used to compare the expression of the CDKN2B-AS1/MIR497/TXNIP axis in these macrophages. We interfered with the expression and function of the axis from upstream to downstream in the macrophage cell line MD to test its roles in macrophage polarization. Compared to cells from healthy donors, cells from rheumatoid arthritis patients expressed a higher level of CD40 and CD80 and a lower level of CD16, CD163, CD206, and CD200R after polarization, they also expressed higher CDKN2B-AS1, lower MIR497, and higher TXNIP. In macrophages from healthy donors, there was no correlation among CDKN2B-AS1, MIR497, and TXNIP. But in macrophages patients, they showed significant correlations. The CDKN2B-AS1 knockdown, MIR497 mimics suppressed M1 polarization but promoted M2 polarization in MD cells, while MIR497 knockdown and TXNIP overexpression did the opposite. This study demonstrated that elevated CDKN2B-AS1 in macrophages promotes M1 polarization and inhibits M2 polarization of macrophage by negatively regulating MIR497, thereby upregulated the expression of TXNIP.
GigaAssay – a high-throughput assay system for molecular functions and cell processes
Authors: Schiller Martin , Benjamin Ronald , Giacoletto Christopher , FitzHugh Zachary , Eames Daniel , Buczek Lindsay , Wu Xiaogang , Newsome Jacklyn , Han Mira , Pearson Tony , Wei Zhi , Banjeree Atoshi , Shen Shirley , Deng Hong-Wen 
Published: July 2021

Abstract
High-throughput assay systems have had a disproportionally large impact on uncovering how cells function, as well as how misregulation can lead to disease. However, no high-throughput assay systems have been developed to systematically address how mutations impact molecular functions or cell processes in human cells. This is arguably one of the most critical assays because human pathology and treatment are largely based upon molecular functions. To address this challenge, herein we engineered, developed, and tested the first modular high-throughput molecular function assay system. Note that this is not a selection lethality screen! This “GigaAssay” single cell / one-pot assay system was adapted to study how variants impact HIV Tat-driven transactivation of a green fluorescent protein (GFP) reporter. We assayed all 1,615 Tat single and 3,429 double amino acid substitutions with no single mutant dropout. Each mutant was assayed with replicate observations in LentiX293T and Jurkat cells with an average of 100s of separately barcoded cDNA molecules and cell groups for each mutant. Each mutant had ~2,000X-90,000X sequencing coverage to measure its transcriptional activity and had p value ranging as low as 10-271. Five independent assay performance assessments with benchmark data, individually tested clones, and replicate comparisons all indicate exceptional reproducibility, accuracy, and robustness. The shortcomings of alanine scanning mutagenesis and protein truncation studies are revealed by including exhaustive substitution tolerance and intragenic epistasis in the typical structure/function analysis(structure/function/tolerance/epistasis). This flexible and extensible technology enables a far more comprehensive holistic view of protein molecular function and yet with a highly simplified single-pot assay.
Research on Capsule Network Based on Attention Mechanism
Authors: Jiao Yan , Zhao Li , Xu Hexin 
Published: July 2021

Abstract
The capsule network has good spatial recognition and has good accuracy in classification and recognition tasks. However, because of the dynamic routing algorithm in the capsule network, the training speed of the capsule network is slow. In order to make better use of the capsule network, reduce For its training cost, this paper proposes a capsule network based on the attention mechanism, and adds the CBAM attention module to the original capsule network to improve the network’s ability to extract information in the feature map channel and information in the feature map space, and improve the network’s learning ability, To reduce the number of network training, thereby reducing the cost of training. This paper conducts experiments based on the original neural network to verify the effectiveness and feasibility of adding the CBAM module to the capsule network. The final result is that the CBAM module can speed up the convergence speed of the capsule network by 50%.
Optimization Method of Equipment Maintenance Resource Scheduling Based on Hidden Semi-Markov Model
Authors: Wang Pengrui , Liu Bailin , Zhao Tao , Cao Pengxiang 
Published: July 2021

Abstract
Aiming at the problems of uneven distribution of maintenance resources and poor planning in the process of complex equipment maintenance, a complex equipment maintenance resource scheduling optimization method based on the hidden semi-Markov model is proposed. Establish a hidden semi-Markov model based on the monitoring data of each maintenance point to evaluate the health status of the equipment, and calculate the importance and priority of each maintenance point based on the health status. Establish the transportation time matrix between the support points and the maintenance points, and propose the maintenance resource scheduling plan between the maintenance points and the support points. The experimental results show that using the monitoring data of four self-propelled artillery to be repaired, the accuracy of the calculated priority is 1.2% higher than the importance. Therefore, the priority of the maintenance point is selected to optimize the resource scheduling plan under the condition of meeting the task requirements and the given maintenance support resources, and shorten the average waiting time of the self-propelled artillery.
Bluetooth 5.2 Technology and Application
Authors: Wang Jian , Liang Hui 
Published: July 2021

Abstract
Bluetooth, a wireless short-distance communication technology, realizes data exchange between fixed devices and mobile device. It widely used in wireless devices, including wireless mice, wireless headsets, notebook computers and other devices. With the development of the times, the traditional Bluetooth technology can no longer meet people’s needs, and a new generation of low-power Bluetooth audio technology standards came into being. Bluetooth 5.2 uses LE Audio technology, which uses low-complexity communication coding and decoding technology to realize low-power transmission of high-quality audio. This paper mainly introduces the new features of Bluetooth 5.2 technology, including enhanced ATT protocol, LE Power Control and LE Isochronous Channels.
Generating Sea Surface Object Image Using Image-to-Image Translation
Authors: Yin Wenbin , Yu Jun , Hu Zhiyi 
Published: July 2021

Abstract
Sea objects training, the conditional adversarial networks require a large number of images to solve image-to-image translation problems. In the case of insufficient samples, it leads to network overfitting and poor training results. This project proposes a conditional adversarial generative model that retains the original background features in the absence of paired samples. The goal of this project is to reduce the deviation of the corresponding output from the original input. Firstly, the object images of different categories are labeled with color masks. Second, sea objects are generated randomly in the original background using model of this project. Finally, the generated results of this approach are compared with other approaches. The experimental results show that, compared with results from other conditional adversarial generative models, the generated object images using model of this project have the characteristics of richer texture and clearer structure.
Calibration of Structured Light Scanning System
Authors: Guo Yi , Ruan Xiaoyi 
Published: July 2021

Abstract
On the basis of studying the calibration method of the camera and the rotating platform, we designed an automatic camera calibration scheme based on four azimuth circles, which can realize the automatic sorting of the mark points. In order to improve the efficiency of identifying the center of the calibration plate, this paper uses RANSAC to improve the RED ellipse center detection algorithm. Experimental verification shows that the improved RED algorithm has increased 29.34% in anti-noise interference ability and 30.10% in center detection accuracy, which effectively guarantees the measurement stability and accuracy of the measurement system. Then, with the aid of the designed calibration board, we fit the rotation center of the turntable using the principle of three points in a circle, which provides a basis for the subsequent point cloud splicing. Experiments show that the back-projection error of the calibration method in this paper is less than 1 pixel, and the calibration accuracy is better than Zhang’s algorithm.
A review on high dynamic range (HDR) image quality assessment
Authors: Gunawan Irwan Prasetya , Cloramidina Ocarina , Syafa’ah Salmaa Badriatu , Febriani Rizcy Hafivah , Kuntarto Guson Prasamuarso , Santoso Berkah Iman 
Published: July 2021

Abstract
This paper presents a literature review on the method of measuring high dynamic range (HDR) image quality. HDR technology can help maximize user satisfaction level when using HDR images-based visual services. The advance of HDR technology indirectly presents a more difficult challenge to the image quality assessment method due to the high sensitivity of the human visual system (HVS) to various kinds of distortions that may arise in HDR images. This is related to the process of HDR image generation, which in general can be classified into two broad categories: the formation using the multiple exposure fusion (MEF) method and the inverse tone mapping operator (ITMO) method. In this paper, we will outline how HDR image quality measurement method works and describe some examples of these measurement methods which are related to the way the HDR images are fabricated. From these methods, it can be seen that most of them are still focused on full-reference and no-reference quality models. We argue that there is still room for the development of reduced-reference HDR image quality assessment.
Migration and transformation of heavy metals during the microwave-assisted thermal hydrolysis of sewage sludge
Authors: Qiu Chunsheng , Zheng Jinxin , Wang Chenchen , Wang Bingbing , Liu Nannan , Wang Dong , Wang Shaopo 
Published: July 2021

Abstract
The migration, transformation and ecological risk of heavy metals (Cr, As, Ni, Cu, Zn, Cd and Pb) in sewage sludge during the microwave-assisted thermal hydrolysis process were investigated under different temperatures (80 °C, 100 °C, 120 °C, 140 °C, and 160 °C). The potential relationship between the bio-availability of heavy metals and the variables of microwave treatment, including pH, ammonium-nitrogen, soluble chemical oxygen demand, pH, soluble protein, soluble polysaccharide and volatile solids, was also explored. The results showed that the migration of heavy metals between solid–liquid phase mainly depended on the temperature. The percentage of all heavy metals (except Cu) in mobile (acid-soluble/exchangeable and reducible) forms decreased after microwave-assisted thermal hydrolysis treatment. The solubilisation of compounds with C = O and O-H accompanied with the generation of organic and inorganic metal halides were also observed in the treated sludge through Fourier transform infrared spectroscopy analysis. NH4+-N showed the highest negative correlation to the bio-availability of most heavy metals (except Cu and Cr) with coefficients (absolute value) over 0.87 (P &lt; 0.05). VS showed a positive correlation to the bio-availability of most heavy metals (except Cu). The total potential ecological risk index (RI) decreased by 46.65% after microwave treatment at 160 °C.
Dificuldades dos municípios da região metropolitana cearense em aderir ao processo de convergência da contabilidade pública: um estudo multicaso
Authors: Da Silva Moura Thais , Sergio do Nascimento Roberto , Viotto Ricardo 
Published: July 2021

Objetivo: O presente estudo multicaso tem por objetivo avaliar as percepções dos municípios brasileiros quanto ao processo de convergência da contabilidade pública às normas internacionais, iniciado em 2008, tendo em vista a importância destes entes federados na prestação primária de bens e serviços públicos à sociedade.
Metodologia: Baseou-se na aplicação de questionário com perguntas estruturadas aplicadas às secretarias de finanças em 7 (sete) municípios da Região Metropolitana de Fortaleza. Além deste aspecto, os municípios foram selecionados com base no PIB estadual e no nível de investimentos públicos por eles realizados.
Resultados: Foram considerados consistentes em evidenciar que 71% dos municípios iniciaram o processo de convergência dentro do prazo estabelecido pela Secretaria do Tesouro Nacional (STN), porém apenas 43% declararam-se encontrar preparados para aplicar as NBCASP. Uma das principais dificuldades relacionadas se referem a falta de investimento em capacitação para os técnicos envolvidos e de sistemas próprios para operarem as alterações determinadas pela STN.
Contribuições do Estudo: Efetivamente a pesquisa comprovou dificuldades reais vivenciadas por parte dos municípios pesquisados que podem comprometer o avanço do processo de convergência Brasil afora, aspectos estes não considerados nos trabalhos anteriormente realizados.
Diversificação das receitas em cooperativas de crédito de livre admissão do Brasil e sua influência sobre desempenho financeiro
Authors: Ribeiro Lucas , Maria Lima Gonçalves Rosiane 
Published: July 2021

Objetivo: Analisar o efeito da diversificação das receitas sobre o desempenho financeiro das cooperativas de crédito de livre admissão brasileiras, no período de 2014 a 2018.
Metodologia: Foi utilizado o modelo de regressão de dados em painel e avaliadas 263 cooperativas de livre admissão brasileiras, perfazendo um total de 2.630 observações. Os dados foram obtidos juntos ao Bacen. As variáveis foram definidas conforme o estudo de Mathuva (2016), em que as variáveis dependentes foram ROA, ROE e suas medidas de volatilidade
Resultados: Os resultados indicaram que a diversificação de atividades nas cooperativas influenciou positivamente o desempenho financeiro. Os sinais encontrados demonstraram que quanto mais equilibrado esse processo melhor é o resultado e menor é o risco, dado pela volatilidade dos retornos. Ao se avaliar especificamente as receitas de serviços, ou seja, o efeito direto dessa fonte de receitas, foi constatada relação inversa com o desempenho e que os retornos se tornam mais voláteis à medida que as cooperativas aumentam as receitas com serviços. Esses resultados podem ser decorrentes tanto do estágio de maturidade das cooperativas nessas linhas de negócios cuja participação na formação das receitas ainda é baixa, quanto sugerem que o desempenho das cooperativas é ampliado à medida em que se fortalece as linhas de negócios já existentes, nas quais a instituição possui vantagens comparativas. O efeito combinado da expansão da prestação de serviços com a expertise nos processos de intermediação financeira é que, no período analisado, exerceu influência sobre o desempenho das cooperativas de livre admissão brasileiras.
Contribuições do Estudo: Avaliar os fatores que exercem influência sobre o desempenho das cooperativas de crédito contribui para a definição de estratégias de promoção de crescimento dessas instituições que exercem importante papel econômico e social na prestação de serviços financeiros. Para literatura, esse estudo contribui para compreensão do comportamento do desempenho das cooperativas de crédito em um contexto de expansão das receitas de serviços pelas instituições financeiras, cujas pesquisas ainda são incipientes e não conclusivas.
Disclosure ambiental dos relatórios corporativos da empresa Natura à luz da teoria da divulgação voluntária
Authors: Voges Claúdia , Broietti Cleber , Rover Suliani 
Published: July 2021

Objetivo: Analisar o nível de disclosure ambiental dos relatórios de sustentabilidade da Natura Cosméticos S.A., no período de 2001 a 2019, à luz da Teoria da Divulgação Voluntária.
Metodologia: Utiliza a metodologia desenvolvida por Clarkson et al. (2008) para coleta e análise dos dados. Estes autores desenvolveram o índice de avaliação do nível da divulgação voluntária sobre políticas, desempenho e insumos ambientais que são divididos em 29 itens de divulgação hard e 16 itens de divulgação soft.
Resultados: Os itens de divulgação hard e soft do disclosure oscilaram no período analisado. A nota máxima obtida pela empresa foi 59 (dentre os 95 pontos possíveis), alcançada no ano de 2013, no relatório dos indicadores da GRI. Cabe destacar que nos itens hard, a variação do nível de evidenciação foi de 9% a 49%, enquanto nos itens soft, a empresa obteve variação de 19% a 88%.
Contribuições do Estudo: A contribuição prática e teórica da pesquisa está vinculada à evidenciação ambiental de uma grande empresa nacional envolvida com o meio ambiente, além de incrementar a literatura de divulgação ambiental nacional.