bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyber legalism: why it fails and what to do about it
Authors: Kello Lucas 
Published: August 2021

Abstract
Western nations face a glaring punishment problem in the cyber domain. Repeatedly, other nations assail their political and economic interests. Repeatedly, Western leaders warn about the gravity of such actions. And yet repeatedly, the victims failed to punish to deter the offenders. This article examines why and how this situation arose and what to do about it. The Western approach to cyber conflict prevention emphasizes the centrality of existing international law and norms. The legal and normative framework is not adequate for this purpose, however, because it does not provide sufficient grounds to credibly respond to actions falling short of war. Consequently, the Western approach has failed spectacularly. It fails to grasp a central truth about contemporary security affairs: much of modern interstate rivalry fits neither the destructive criteria of war nor the acceptable boundaries of peaceful rivalry. Rather, it is unpeace, or mid-spectrum rivalry that is more damaging than traditional peacetime activity, but not physically violent like war. Nations use cyberspace to achieve some of the political and strategic objectives of war without firing a single gun. The lack of an effective Western response betrays not tolerance of aggression but a failure to devise a response strategy commensurate with the legal and doctrinal ambiguities of unpeace. Existing law and norms are a source of the problem, not its solution. An interim solution must be found instead in the development of new doctrine—in a consequentialist strategy that affects adversaries’ material interests to deter actions which international law and security strategy do not ordinarily recognize as deserving a strong response.
Novel insights into the athlete’s heart: is myocardial work the new champion of systolic function?
Authors: Tokodi Márton , Oláh Attila , Fábián Alexandra , Lakatos Bálint Károly , Hizoh István , Ruppert Mihály , Sayour Alex Ali , Barta Bálint András , Kiss Orsolya , Sydó Nóra , Csulak Emese , Ladányi Zsuzsanna , Merkely Béla , Kovács Attila , Radovits Tamás 
Published: August 2021

Abstract

Aims
We sought to investigate the correlation between speckle-tracking echocardiography (STE)-derived myocardial work (MW) and invasively measured contractility in a rat model of athlete's heart. We also assessed MW in elite athletes and explored its association with cardiopulmonary exercise test (CPET)-derived aerobic capacity.

Methods and results
Sixteen rats underwent a 12-week swim training program and were compared to controls (n = 16). STE was performed to assess global longitudinal strain (GLS), which was followed by invasive pressure-volume analysis to measure contractility [slope of end-systolic pressure–volume relationship (ESPVR)]. Global MW index (GMWI) was calculated from GLS curves and left ventricular (LV) pressure recordings. In the human investigations, 20 elite swimmers and 20 healthy sedentary controls were enrolled. GMWI was calculated through the simultaneous evaluation of GLS and non-invasively approximated LV pressure curves at rest. All subjects underwent CPET to determine peak oxygen uptake (VO2/kg). Exercised rats exhibited higher values of GLS, GMWI, and ESPVR than controls (−20.9 ± 1.7 vs. −17.6 ± 1.9%, 2745 ± 280 vs. 2119 ± 272 mmHg·%, 3.72 ± 0.72 vs. 2.61 ± 0.40 mmHg/μL, all PExercise &lt; 0.001). GMWI correlated robustly with ESPVR (r = 0.764, P &lt; 0.001). In humans, regular exercise training was associated with decreased GLS (−17.6 ± 1.5 vs. −18.8 ± 0.9%, PExercise = 0.002) but increased values of GMWI at rest (1899 ± 136 vs. 1755 ± 234 mmHg·%, PExercise = 0.025). GMWI exhibited a positive correlation with VO2/kg (r = 0.527, P &lt; 0.001).

Conclusions
GMWI precisely reflected LV contractility in a rat model of exercise-induced LV hypertrophy and captured the supernormal systolic performance in human athletes even at rest. Our findings endorse the utilization of MW analysis in the evaluation of the athlete’s heart.
Using alternative teaching and learning approaches to deliver clinical microbiology during the COVID-19 pandemic
Authors: Joshi Lovleen Tina 
Published: August 2021

ABSTRACTThe COVID-19 (coronavirus disease 2019) pandemic has had significant impacts upon higher education teaching. Clinical microbiology teaching is primarily focused on a combination of practical skill development and didactic delivery of content. In the pandemic, the absence of in-person teaching has led to educators adapting in-person content for online platforms and delivery. This commentary covers alternative innovative and engaging teaching approaches to deliver clinical microbiology content during the COVID-19 pandemic.
Exploring new netting material for fishing: the low light level of a luminous netting negatively influences species separation in trawls
Authors: Karlsen Junita Diana , Melli Valentina , Krag Ludvig Ahm 
Published: August 2021

AbstractWe tested if a newly developed luminous netting, VISIONET, could change the vertical behaviour of six commercially important species in a Nephrops (Nephrops norvegicus) trawl fishery. We inserted a V-shaped piece of VISIONET ascending on each side of the tapered section just ahead of a divided codend. The length-based effect on the vertical separation of fishes and Nephrops was quantified, and we evaluated if the presence of VISIONET had the potential to increase the fish capture in the upper compartment. Contrary to our expectation, gadoids entered the lower compartment more frequently than in the control trawl. This was similar to that previously found when applying green LED lights in the tapered section, however opposite for haddock (Melanogrammus aeglefinus). The flatfishes did not respond. Large Nephrops significantly increased their preference for the lower compartment. Our results show that low intensity light is sufficient to alter the vertical distribution of both fishes and Nephrops. Responses of fishes to different variables, including light intensities, need to be studied in more detail to understand the underlying mechanisms and to ultimately reduce unwanted catch more efficiently. Luminous netting can be integrated in any given trawl design and does not require batteries or electronics.
Visual Portrayals of People in Need: The Impact of Refugee Depictions, Compassion, and Support for Humanitarian Aid
Authors: Dumitrescu Delia , Bucy Erik P 
Published: August 2021

Abstract
As conflicts flare around the world, images of refugees have become a familiar presence in Western media. Drawing on existing accounts of visual influence, this analysis explores how (un)sympathetic refugee portrayals in news accounts affect distant viewers’ compassion responses and refugee policy attitudes. The study reports the results of three survey experiments, in Sweden, the United States, and the UK, involving 25 unique images and over 4,500 combined respondents. Building on previous work on Moral Foundations Theory, we find the manifest vulnerability of depicted refugees to be an important influence on how visual portrayals evoke sympathy and impact conservatives’ (but not liberals’) compassion responses. Once activated, compassion is found to mediate the effect of refugee portrayals on right-wing support for refugee aid.
Lebanese pharmacy core competencies framework: tool validation for self-declared assessment
Authors: Hajj Aline , Hallit Souheil , Sacre Hala , Akel Marwan , Zeenny Rony M , Salameh Pascale 
Published: August 2021

Abstract

Objectives
The Order of Pharmacists of Lebanon, the official pharmacists’ association in Lebanon, had suggested a core competencies framework based on global and international frameworks and adapted to the local context. The objective of this study was to validate the structure of this comprehensive set of competencies in the Lebanese context of pharmacy practice.

Methods
The framework structure was assessed through multiple factor analyses, correlational and reliability measures of self-declared assessment, based on a cross-sectional survey of practising pharmacists.

Key findings
The framework had adequate structural validity and reliability: all measured coefficients were of appropriate magnitude. Behaviours adequately loaded on competencies, and competencies adequately loaded on domains and the entire framework. The exploratory factor analysis showed an adequate distribution of competencies in domains. Domains were also inter-correlated, without over-correlation.

Conclusions
Our results are an essential step towards standardizing pharmacy competencies in Lebanon and show that the Lebanese core competencies framework developed by the Order of Pharmacists of Lebanon is structurally valid and reliable, although not yet applied in the Lebanese educational system. This tool would be helpful to assess the minimum competencies of pharmacists upon and after graduation.
A review of remdesivir for COVID-19 in pregnancy and lactation
Authors: Jorgensen Sarah C J , Davis Matthew R , Lapinsky Stephen E 
Published: August 2021

Abstract
Mounting evidence suggests that pregnant people have an elevated risk of severe COVID-19-related complications compared with their non-pregnant counterparts, underscoring the need for effective prevention and treatment strategies. However, despite progress in innovative and flexible trial designs during the COVID-19 pandemic, regressive policies excluding pregnant and breastfeeding people from biomedical research persist. Remdesivir, a broad-spectrum antiviral, was the first drug licensed for the treatment of COVID-19, based on data showing it reduced the time to recovery in hospitalized patients. Pregnant and breastfeeding people were specifically excluded from all clinical trials of remdesivir in COVID-19, but data are accumulating from post-marketing registries, compassionate use programmes and case series/reports. In this review we synthesize these data and highlight key knowledge gaps to help inform clinical decision-making about its use in pregnancy and lactation.
Attitude of Saudi Plastic Surgery Residents Toward Pursuing Burn Practice
Authors: Arab Khalid A , Alfaqeeh Faisal A , Alowais Fahad A 
Published: August 2021

Abstract
Burn injuries comprise the most common accidents worldwide. The delivery of burn care has been adversely affected by the absence of effective burn management and aesthetic services. This study attempts to address the attitude of Saudi residents of plastic surgery toward obtaining a burn fellowship and to examine the factors that might influence their decisions in this regard. An online survey was sent to 39 plastic surgery residents in Saudi Arabia including levels from PGY 1 to 6 in the academic year of 2019. The questionnaire was used to demonstrate interest, knowledge, and major factors influencing or discouraging residents from choosing Burn as a subspecialty in their future career. Residents responded to knowledge questions on a scale of 3 (below average/average/above average). The response rate was 84%. Thirty-three residents completed the questionnaire. The age group was between 30 and 34 years. Only 27% of the respondents expressing interest in burn practice. The main factors that make the plastic surgery resident avoid pursuing burn fellowship were multiple operations sessions, lifestyle, financial outcome, and emotional aspects. On the other hand, the paucity of burn surgeons and being involved in the humanitarian mission were attracting factors. Most of the residents believe that burn must be obligatory and continue to be part of all plastic surgery training programs (100%). In Saudi Arabia, the relative paucity of specialist mentors on plastic surgery programs may limit residents’ exposure to subspecialties such as burn during plastic surgery rotational experiences. The findings from this survey may help plastic surgery program directors or burn surgeons, in particular, to find out strategies to attract future trainees.
The aminoshikimic acid pathway in bacteria as source of precursors for the synthesis of antibacterial and antiviral compounds
Authors: Escalante Adelfo , Mendoza-Flores Rubén , Gosset Guillermo , Bolívar Francisco 
Published: August 2021

Abstract
The aminoshikimic acid (ASA) pathway comprises a series of reactions resulting in the synthesis of 3-amino-5-hydroxybenzoic acid (AHBA), present in bacteria such as Amycolatopsis mediterranei and Streptomyces. AHBA is the precursor for synthesizing the mC7N units, the characteristic structural component of ansamycins and mitomycins antibiotics, compounds with important antimicrobial and anticancer activities. Furthermore, aminoshikimic acid, another relevant intermediate of the ASA pathway, is an attractive candidate for a precursor for oseltamivir phosphate synthesis, the most potent anti-influenza neuraminidase inhibitor treatment of both seasonal and pandemic influenza. This review discusses the relevance of the key intermediate AHBA as a scaffold molecule to synthesize diverse ansamycins and mitomycins. We describe the structure and control of the expression of the model biosynthetic cluster rif in A. mediterranei to synthesize ansamycins and review several current pharmaceutical applications of these molecules. Additionally, we discuss some relevant strategies developed for overproducing these chemicals, focusing on the relevance of the ASA pathway intermediates kanosamine, AHAB, and ASA.
Prospect patents and CRISPR; rivalry and ethical licensing in a semi-commons environment
Authors: Panagopoulos Andreas , Sideri Katerina 
Published: August 2021

Abstract
The prospect theory of patents views patents as a tool for the development and commercialization of inventions. Prospect patents rely on broad control of technology so that rivalry between competing products is diminished thus avoiding waste of common-pool resources. The theory has been widely criticized but in this article we argue that it does not address the realities of an economy where many innovations are created by universities. Although university patents on inventions such as new gene-editing tools fit squarely in the definition of prospect patents, they may still allow rivalry to resurface at the commercialization stage. This rivalry is not between competing firms; it is between competing visions of the prospect: ‘the university’s vision versus the licensees.’ We use as a case study the CRISPR-Cas9 technology invented by universities and commercialized by licensees. We employ patent landscape analysis showing that CRISPR-Cas9’s prospects comply with the characteristics of prospect patents and, above all, diminish rivalry at the commercialization stage. As the lack of competition leads to excessive treatment prices, tensions arise because the licensee understands CRISPR-Cas9 as a revenue-generating prospect, whereas the university views it as a technology requiring broad distribution. Such discerning visions can breed rivalry between licensor and licensee despite broad patent rights. In addressing this we turn to the literature on semi-commons, which implies an environment where private rights of exclusion such as prospect patents work with ethical licenses and a domain of resources open for reuse to foster innovation. We argue that in this environment, universities can emerge as important actors in the regulatory enterprise through additional ex post licensing. To this end, we propose a market-based solution in the form of a license allowing for patent re-licensing if the licensee fails to address a predefined demand for the final product.
Curcumae Radix: a review of its botany, traditional uses, phytochemistry, pharmacology and toxicology
Authors: Ao Mingyue , Li Xing , Liao Yujiao , Zhang Chunling , Fan Shunming , Hu Changjiang , Chen Zhimin , Yu Lingying 
Published: August 2021

Abstract

Objectives
Curcumae Radix, the medicinal part is radix, commonly called as Yujin (Chinese:郁金), is a widely used traditional Chinese medicine for its high medicinal value and health benefits. Curcumae Radix has been used to treat conditions such as syndrome of heat disease and unconsciousness, epilepsy and internal stagnation of phlegm, qi stagnation and blood stasis, dysmenorrhoea, jaundice, cholelithiasis caused by dampness heat of liver and gallbladder. This review aims to summarize the botany, traditional usages, processing, phytochemistry, quality control, pharmacology and toxicology of Curcumae Radix to better understand its therapeutic potential.

Key findings
So far, a variety of chemical constituents have been isolated and identified from Curcumae Radix, mainly including volatile oil and diphenylheptanes. Modern research shows that the extracts and compounds from Curcumae Radix possess wide-ranging pharmacological effects, including anti-tumour, hepatoprotective, anti-inflammatory and analgesic, anti-thrombosis, as well as effects on the nervous system and others.

Summary
Curcumae Radix holds an important position in traditional system of medicine. It is cost-effective and an important plant with curative application in contemporary medicine. However, further in-depth studies are also needed to determine the medical uses of this plant and its chemical constituents, pharmacological activity, quality control and toxicology.
Synthetic breath-hold CT generation from free-breathing CT: a novel deep learning approach to predict cardiac dose reduction in deep-inspiration breath-hold radiotherapy
Authors: Koide Yutaro , Shimizu Hidetoshi , Wakabayashi Kohei , Kitagawa Tomoki , Aoyama Takahiro , Miyauchi Risei , Tachibana Hiroyuki , Kodaira Takeshi 
Published: August 2021

Abstract
Deep-inspiration breath-hold radiotherapy (DIBH-RT) to reduce the cardiac dose irradiation is widely used but some patients experience little or no reduction. We constructed and compared two prediction models to evaluate the usefulness of our new synthetic DIBH-CT (sCT) model. Ninety-four left-sided breast cancer patients (training cohort: n = 64, test cohort: n = 30) underwent both free-breathing and DIBH planning. The U-Net-based sCT generation model was developed to create the sCT treatment plan. A linear prediction model was constructed for comparison by selecting anatomical predictors of past literature. The primary prediction outcome is the mean heart dose (MHD) reduction, and the coefficient of determination (R2), root mean square error (RMSE) and mean absolute error (MAE) were calculated. Moreover, we evaluated the heart and lungs contours’ similarity and Hounsfield unit (HU) difference between both images. The median MHD reduction was 1.14 Gy in DIBH plans and 1.09 Gy in sCT plans (P = 0.96). The sCT model achieved better performance than the linear model (R2: 0.972 vs 0.450, RMSE: 0.120 vs 0.551, MAE: 0.087 vs 0.412). The organ contours were similar between DIBH-CT and sCT: the median Dice (DSC) and Jaccard similarity coefficients (JSC) were 0.912 and 0.838 for the heart and 0.910 and 0.834 for the lungs. The HU difference in the soft-tissue region was smaller than in the air or bone. In conclusion, our new model can generate the affected CT by breath-holding, resulting in high performance and well-visualized prediction, which may have many potential uses in radiation oncology.
Ureteral intussusception: a case report and review of literature
Authors: Aljuhayman Ahmed , Alothman Ali , Bin Hamri Saeed 
Published: August 2021

Abstract
Ureterorenoscopy (URS) is a minimal invasive procedure used for diagnosis and management of the upper urinary tract. Due to the vast advancement in URS technologies, the efficacy and safety greatly improved with lower complication rates. Intussusception is a rare complication of URS. We report a case of iatrogenic ureteral intussusception that was managed with ileal interposition.
Benchmarking hall-induced magnetoacoustic to Alfvén mode conversion in the solar chromosphere
Authors: Raboonik Abbas , Cally Paul S 
Published: August 2021

ABSTRACT
A 2.5D numerical model of magnetoacoustic-Alfvén linear mode conversions in the partially ionized low solar atmosphere induced by the Hall effect is surveyed, varying magnetic field strength and inclination, and wave frequency and horizontal wavenumber. It is found that only the magnetic component of wave energy is subject to Hall-mediated conversions to Alfvén wave-energy via a process of polarization rotation. This strongly boosts direct mode conversion between slow magnetoacoustic and Alfvén waves in the quiet low chromosphere, even at mHz frequencies. However, fast waves there, which are predominantly acoustic in nature, are only subject to Hall-induced conversion via an indirect two-step process: (i) a geometry-induced fast–slow transformation near the Alfvén-acoustic equipartition height zeq; and (ii) Hall-rotation of the fast wave in z &gt; zeq. Thus, for the two-stage process to yield upgoing Alfvén waves, zeq must lie below or within the Hall-effective window 0 ≲ z ≲ 700 km. Magnetic field strengths over 100 G are required to achieve this. Since the potency of this Hall effect varies inversely with the field strength but directly with the wave frequency, only frequencies above about 100 mHz are significantly affected by the two-stage process. Increasing magnetic field inclination θ generally strengthens the Hall convertibility, but the horizontal wavenumber kx has little effect. The direct and indirect Hall mechanisms both have implications for the ability of MHD waves excited at the photosphere to reach the upper chromosphere, and by implication the corona.
The impact of non-ideal magnetohydrodynamic processes on discs, outflows, counter-rotation, and magnetic walls during the early stages of star formation
Authors: Wurster James , Bate Matthew R , Bonnell Ian A 
Published: August 2021

ABSTRACT
Non-ideal magnetohydrodynamic (MHD) processes – namely Ohmic resistivity, ambipolar diffusion, and the Hall effect – modify the early stages of the star formation process and the surrounding environment. Collectively, they have been shown to promote disc formation and promote or hinder outflows. But which non-ideal process has the greatest impact? Using three-dimensional smoothed particle radiation non-ideal MHD simulations, we model the gravitational collapse of a rotating, magnetized cloud through the first hydrostatic core phase to shortly after the formation of the stellar core. We investigate the impact of each process individually and collectively. Including any non-ideal process decreases the maximum magnetic field strength by at least an order of magnitude during the first core phase compared to using ideal MHD, and promotes the formation of a magnetic wall. When the magnetic field and rotation vectors are anti-aligned and the Hall effect is included, rotationally supported discs of r ≳ 20 au form; when only the Hall effect is included and the vectors are aligned, a counter-rotating pseudo-disc forms that is not rotationally supported. Rotationally supported discs of r ≲ 4 au form if only Ohmic resistivity or ambipolar diffusion are included. The Hall effect suppresses first core outflows when the vectors are anti-aligned and suppresses stellar core outflows independent of alignment. Ohmic resistivity and ambipolar diffusion each promote first core outflows and delay the launching of stellar core outflows. Although each non-ideal process influences star formation, these results suggest that the Hall effect has the greatest influence.