bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal resolution of melanogenesis determine fatty acid metabolism as key skin pigment regulator
Authors: Sultan Farina , Basu Reelina , Murthy Divya , Kochar Manisha , Attri Kuldeep S. , Aggrawal Ayush , Kumari Pooja , Dnyane Pooja , Singh Archana , Gadgil Chetan , Bhavesh Neel S. , Singh Pankaj K. , Natarajan Vivek T. , Gokhale Rajesh S. 
Published: April 2021

AbstractTherapeutic methods to modulate skin pigmentation has important implications for skin cancer prevention and for treating meta-inflammatory-triggered cutaneous conditions. Modulators of cAMP signalling of melanocyte have met with minimal clinical efficacy. Towards defining new potential targets, we followed temporal dynamics orchestrating melanocyte differentiation by using a cell-autonomous pigmentation model. Our study elucidates three dominant phases of synchronized metabolic and transcriptional reprogramming. The induction phase is concomitant with a paradoxical decrease in MITF levels, reduced proliferation, and increased anabolic metabolism mediated by AKT phosphorylation. The melanogenic phase shows rapid uptake of glucose and fatty acid, transiently forming lipid droplets through SREBF1-mediated regulation of fatty acid metabolism. This heightened bioenergetic activity impairs mitochondria and the recovery phase is marked by a shift to aerobic glycolysis and activation of the NRF2 detoxication pathway. Finally, we show that inhibitors of lipid metabolism indeed resolve hyper-pigmentary conditions in a guinea pig UV-tanning model. Our studies reveal metabolic control mechanisms of melanocytes that could govern the balance between differentiation and proliferation in a variety of cutaneous diseases.
Does a Clarke-Groves type tax prevent free riding when implementing Eurobonds?
Authors: Contreras Carlos , Angulo Julio 
Published: April 2021

PurposeThe purpose of this paper is to propose a Clarke-Groves Tax (CGT) type as a remedy to the criticism that the implementation of Eurobonds has raised regarding the risk of undermining fiscal discipline. In this model, a government minimizes its sovereign debt-to-GDP ratio in a given period and decides whether to join a common sovereign debt club. In doing so, it exposes itself to a positive or negative tax burden while benefiting from the liquidity premium involved in creating a secure asset. The authors found that the introduction of this tax may prevent free riding behaviours if Eurobonds were to be implemented. To illustrate this, the authors provide some numerical simulations for the Eurozone.Design/methodology/approachIn the model presented, a government which optimizes a social utility function decides whether to join the common debt club.FindingsThe adoption of the proposed tax could prevent free-riding behaviours and, therefore, encourages participation by those countries with lower debt levels that would have not otherwise taken part in this common debt mechanism. Under certain circumstances, we can expect the utility of all members of this club to improve. The bias in the distribution of gains might be mitigated by regulating the tax rule determining the magnitude of payment/reward. The proportion of the liquidity premium, arising from the implementation of a sovereign safe asset, has a decisive impact on the degree of the governments’ utility enhancement.Research limitations/implicationsThe adoption of a CGT would require Eurobonds club members to reach an agreement on “the” theoretical model for determining the sovereign debt yield. One of the limitations of this model is considering the debt-to-GDP ratio as the sole determinant of public debt yields. Moreover, the authors assumed the relationship between the debt-to-GDP ratio and funding costs to be identical for all countries. Any progress in the implementation of the proposed transfer scheme would require a more realistic and in-depth analysis.Practical implicationsA new fiscal rule based on compensating countries with lower public debt levels could be a way to mitigate free-riding problems if a Eurobond mechanism is to be established.Originality/valueThis fiscal rule has not been proposed or analysed before in a context such as that considered by this paper.
Innovative m-car rental service quality in India
Authors: Shah Tejas R. , Shah Tejal T. 
Published: April 2021

Purpose
The purpose of the study is to explore and analyze m-car rental service quality dimensions.

Design/methodology/approach
Exploratory factor analysis method is applied to explore the m-car rental service quality dimensions. Further, confirmatory factor analysis is done to prove the reliability and validity of the factors using AMOS 22.0.

Findings
The results reveal the m-car rental service quality dimensions: ambient quality, technical quality, comfort, safety and employee service, mobile convenience, mobile responsiveness, mobile efficiency and reliability and mobile safety and billing.

Research limitations/implications
The explored dimensions of car rental services are in Indian environment. So, these dimensions can be further validated in other similar cultural context.

Practical implications
The proposed measurements can also be applied to measure and compare the service quality performance of car rental firms.

Originality/value
Current literature does not confirm the stable factor structure of m-car rental service quality. This study confirms the reliable and valid dimensions of care rental service through mobile app.
Numerical study on the dynamic characteristics of water-lubricated rubber bearing under asperity contact
Authors: Xiang Guo , Wang Yijia , Wang Cheng , Lv Zhongliang 
Published: April 2021

Purpose
In this study, the dynamic characteristics of the water-lubricated rubber bearing considering asperity contact are numerically studied, including water-film stiffness and damping coefficients and plastic-elastic contact stiffness coefficient.

Design/methodology/approach
The Kogut-Etsion elastic-plastic contact model is applied to calculate the contact stiffness coefficient at the bearing-bush interface and the perturbed method is used to calculate the stiffness and damping coefficients of water-film. In addition, the rubber deformation is determined by the finite element method (FEM) during the simulation. Parametric studies are conducted to assess the effects of the radial clearance, rubber thickness and elastic modulus on the dynamic characteristic of water-lubricated rubber bearing.

Findings
Numerical results indicate that stiffness and damping coefficients of water film and the contact stiffness of asperity are increased with the decreasing of the radial clearance and the dynamic coefficients are less sensitive to the rubber thickness compared with the elastic modulus of rubber. Furthermore, due to the existed groove, a sudden change of the water film direct stiffness and damping coefficients is observed when the eccentricity ratio ranges from 0.6 to 1.0.

Originality/value
It is expected this study can provide more information to establish a dynamic equation of water-lubricated rubber bearings exposed to mixed lubrication conditions.
The goal is attainable: the effects of goal gradient and sub-goals on escalation of commitment in a new product evaluation
Authors: Liang Beichen 
Published: April 2021

Purpose
The purpose of this study is to investigate whether, in the context of making a go/no-go decision regarding a failing new product, the use of a stopping rule and/or a new decision-maker would reduce the escalation of commitment (EOC).

Design/methodology/approach
This study uses a classroom experiment design and uses logistic regression and a chi-square test to analyze its data.

Findings
The findings show that both responsible and non-responsible participants are more likely to perceive the negative performance of a new product as less negative and believe that the goal for the product can be reached when there is a stopping rule and proximal negative feedback indicates a level of performance below but very close to it than when there is no stopping rule. Therefore, they are more likely to continue the failing new product, whether they are responsible for the product or not. However, non-responsible decision-makers are more likely than their responsible counterparts to discontinue the failing new product in the absence of a stopping rule.

Research limitations/implications
This paper extends the theory of EOC by showing that the use of a stopping rule and/or a new decision-maker may not reduce EOC.

Practical implications
This paper provides useful guidelines for managers on how to reduce EOC.

Originality/value
The originality and value of this paper are found in the investigation of a situation in which the use of a stopping rule and/or a new decision-maker may not reduce the EOC.
Innovation in the subsistence marketplace: an analysis considering multiple concepts and approaches
Authors: Nogami Vitor Koki da Costa , Veloso Andres Rodriguez 
Published: April 2021

Purpose
The purpose of this paper is to explore the different concepts of innovation in the subsistence marketplace from top-down and bottom-up approaches. This study analyzes the literature on the theme and identified research gaps by constructing a framework based on approaches and innovation concepts, which can guide future research efforts. Additionally, this paper presents two case studies, which can improve the way innovation is developed and diffused in the subsistence marketplace.

Design/methodology/approach
Through a literature review, this study develops a framework by analyzing innovation concepts in the subsistence marketplace (i.e. base of the pyramid innovation, disruptive innovation, frugal innovation, reverse innovation and inclusive innovation) in light of subsistence marketplace approaches (top-down and bottom-up).

Findings
The analysis showed critical research gaps, especially a lack of studies involving disruptive and frugal innovations from a bottom-up approach. This paper also concludes that the top-down approach is more common than the bottom-up one. To fill these gaps, this study presents two business plans by illustrating disruptive innovation vs bottom-up approach and frugal innovation vs bottom-up approach.

Originality/value
The use of real business plans to illustrate proposals having an actual impact on subsistence marketplace regions sheds light on how to address these challenges. By doing so, this paper intends to fill the theoretical gap in disruptive and frugal innovations within a bottom-up approach to promote the development and diffusion of different types of innovation in the subsistence marketplace, and thus provide solutions to alleviate poverty.
B2B engagement within an internet of things ecosystem
Authors: Soltani Sadia 
Published: April 2021

PurposeThis study aims to investigate business-to-business (B2B) engagement within an internet of things (IoT) ecosystem. A conceptual framework is proposed that can be used for building engagement strategies considering key actors within an IoT ecosystem.Design/methodology/approachThe study used an integrative literature review as a research method and investigated engagement across several disciplines along with antecedents and outcomes of engagement to form an understanding of IoT engagement.FindingsThe findings in this study revealed IoT engagement antecedents as IoT readiness, commitment, communication, involvement and support and, consequently, the outcomes of IoT engagement as trust, loyalty, better performance and satisfaction. Furthermore, IoT engagement needs to be considered from three perspectives, namely, from a multidimensional perspective, beyond a dyad perspective and from the service-dominant logic perspective, which suggests thinking of goods as services and highlights the importance of value co-creation.Research limitations/implicationsAs the study of B2B engagement within the IoT ecosystem is conceptual, empirical investigations are suggested for elaborating on the findings.Practical implicationsThe conceptual framework provides managers within an IoT ecosystem with thorough recommendations on why to change their perspectives toward engagement; it points out drivers of engagement that need to be maintained and adds IoT readiness as a new antecedent to engagement literature.Originality/valueThis study contributes a coherent conceptualization of actors’ engagement within IoT ecosystems and enhances both the theoretical and practical domain of B2B engagement.
Advanced cuttlefish optimizer-random decision forest (ACORDF) based design of fractional order PID controller for higher-order time-delay system
Authors: George Thomas , Ganesan V. 
Published: April 2021

Purpose
The purpose of this manuscript, a state feedback gain depends on the optimal design of fractional order PID controller to time-delay system is established. In established optimal design known as advanced cuttlefish optimizer and random decision forest that is combined performance of random decision forest algorithm (RDFA) and advanced cuttlefish optimizer (ACFO).

Design/methodology/approach
The proposed ACFO uses the concept of crossover and mutation operator depend on position upgrading to enhance its search behavior, calculational speed as well as convergence profile at basic cuttlefish optimizer.

Findings
Fractional order proportional-integrator-derivative (FOPID) controller, apart from as tuning parameters (kp, ki and kd) it consists of two extra tuning parameters λ and µ. In established technology, the increase of FOPID controller is adjusted to reach needed responses that demonstrated using RDFA theory as well as RDF weight matrices is probable to the help of the ACFO method. The uniqueness of the established method is to decrease the failure of the FOPID controller at greater order time delay method with the help of controller maximize restrictions. The objective of the established method is selected to consider parameters set point as well as achieved parameters of time-delay system.

Originality/value
In the established technique used to evade large order delays as well as reliability restrictions such as small excesses, time resolution, as well as fixed condition defect. These methods is implemented at MATLAB/Simulink platform as well as outcomes compared to various existing methods such as Ziegler-Nichols fit, curve fit, Wang method, regression and invasive weed optimization and linear-quadratic regression method.
How do forensic inpatients’ interpersonal sensitivity to dominance and perceptions of staff coercion impact upon anger and rates of aggression?
Authors: Holley Jessica , Tapp James , Draycott Simon 
Published: April 2021

Purpose
Coercive practices – which are used as means to manage violent/aggressive behaviour in secure forensic settings – have come under scrutiny in recent years due to their paradoxical effects on provoking further service user aggression and violence. Previous research has found relationships between increased service user aggression with both service users’ interpersonal styles and perceptions of staff coercion (i.e. staff limit setting). This paper aims to investigate whether forensic service users’ levels of interpersonal sensitivity to dominance increase levels of self-reported anger and rates of aggression towards staff through perceptions of staff coercion.

Design/methodology/approach
In a cross-sectional quantitative study design, 70 service users were recruited from one high and two medium secure forensic hospitals. Standardised measures were completed by service users and recorded incident data was collected within the past year. Correlation and mediation analyses were run to investigate the relationship between study variables.

Findings
A significant relationship was found between service users’ interpersonal sensitivity to dominance and self-reported rates of anger, where forensic service users’ who had higher levels of interpersonal sensitivity to others’ dominance were likely to report higher rates of anger. No significant relationships were found between all other study variables.

Practical implications
The findings from this study contradict previous research where coercive practices may not necessarily increase rates of aggression towards staff but, in the context of service users’ interpersonal sensitivities to dominance, it may be more useful to consider the way in which coercive practices are implemented.

Originality/value
There is a gap in the literature, which looks at the way in which forensic service users perceive coercive practices in relation to their interpersonal sensitivities and whether this too has an impact upon service user aggression.
Plenary Indulgence for the Personal Participation in Crusades to the Holy Land as Presented by Crusade Preachers
Authors: PORTNYKH VALENTIN L. 
Published: April 2021

AbstractThis article discusses one of the main phenomena of the crusading movement: how preachers of the crusades to the Holy Land made the crusade indulgence attractive to would‐be crusaders. Since a plenary indulgence for the participants of the crusades is likely to have been introduced by the papacy at the beginning of the crusading movement in the eleventh century, this was used in crusade preaching throughout the whole period of crusading to the Holy Land. Given that the plenary indulgence is omnipresent in almost all sources related to crusade preaching, it is highly likely to have been deemed a useful argument to attract people to the crusading movement. Drawing on a large body of scholarship concerning the motivations of crusaders to the Holy Land, this article focuses on the ways in which preachers invented a number of ways to make the indulgence very attractive for sermon listeners.
Neoadjuvant radiotherapy for locally advanced and high‐risk breast cancer
Authors: Chidley Phoebe , Foroudi Farshad , Tacey Mark , Khor Richard , Yeh Janice , Bevington Elaine , Hyett Anthony , Loh Su Wen , Chew Grace , McCracken James , Neoh Derek , Yeo Belinda , Baker Caroline , Jassal Sunil , Law Michael , Zantuck Natalie , Cokelek Margaret , Guerrieri Mario , Brown Belinda , Stoney David , Ng Michael , Chao Michael 
Published: April 2021

AbstractIntroductionNeoadjuvant radiotherapy (NART) as part of a multi‐modality approach for locally advanced breast cancer (LABC) requires further investigation. Importantly, this approach may allow for a single‐staged surgical procedure, with mastectomy and immediate autologous reconstruction. Multiple other potential benefits of NART include improved pathological downstaging of breast disease, reduced overall treatment time, elimination of time period with breast tissue deficit and improved patient satisfaction.MethodsThis is a retrospective multi‐institutional review of patients with LABC and high‐risk breast disease undergoing NART. Eligible patients sequentially underwent neoadjuvant chemotherapy (NACT) with or without HER2‐targeted therapy, NART, followed by mastectomy with immediate autologous breast reconstruction (BR) 4‐ to 6 weeks post‐completion of radiotherapy. Patient and tumour characteristics were analysed using descriptive statistics. Surgical complications were assessed using the Clavien–Dindo Classification (Ann Surg 2004; 240: 205).ResultsFrom 3/2013 to 9/2019, 153 patients were treated with NART. The median age was 47 years (IQR 42–52), with median body mass index of 27. Eighteen patients experienced Grade 3 acute surgical complications. This included 13 Grade 3B breast‐site events and 9 Grade 3B donor‐site events, where further surgical intervention was required for management of wound infection, wound dehiscence, flap or mastectomy skin necrosis, haematoma and internal mammary venous anastomotic thrombosis. No autologous flap loss was observed.ConclusionNeoadjuvant radiotherapy facilitates a single‐stage surgical procedure with mastectomy and immediate autologous BR, eliminating the delay to reconstructive surgery and thus shortening a woman’s breast cancer journey. The findings of this review support the use of NART, with comparable rates of surgical complications to standard sequencing.
Climate Ambition and Sustainable Development for a New Decade: A Catalytic Framework
Authors: Chan Sander , Boran Idil , van Asselt Harro , Ellinger Paula , Garcia Miriam , Hale Thomas , Hermwille Lukas , Liti Mbeva Kennedy , Mert Ayşem , Roger Charles B. , Weinfurter Amy , Widerberg Oscar , Bynoe Paulette , Chengo Victoria , Cherkaoui Ayman , Edwards Todd , Gütschow Malin , Hsu Angel , Hultman Nathan , Levaï David , Mihnar Saffran , Posa Sara , Roelfsema Mark , Rudyk Bryce , Scobie Michelle , Shrivastava Manish Kumar 
Published: April 2021

AbstractThis paper examines the Global Climate Action Agenda (GCAA) and discusses options to improve sub‐ and non‐state involvement in post‐2020 climate governance. A framework that stimulates sub‐ and non‐state action is a necessary complement to national governmental action, as the latter falls short of achieving low‐carbon and climate‐resilient development as envisaged in the Paris Agreement. Applying design principles for an ideal‐type orchestration framework, we review literature and gather expert judgements to assess whether the GCAA has been collaborative, comprehensive, evaluative and catalytic. Results show that there has been greater coordination among orchestrators, for instance in the organization of events. However, mobilization efforts remain event‐driven and too little effort is invested in understanding the progress of sub‐ and non‐state action. Data collection has improved, although more sophisticated indicators are needed to evaluate climate and sustainable development impacts. Finally, the GCAA has recorded more action, but relatively little by actors in developing countries. As the world seeks to recover from the COVID‐19 crisis and enters a new decade of climate action, the GCAA could make a vital contribution in challenging times by helping governments keep and enhance climate commitments; strengthening capacity for sub‐ and non‐state action; enabling accountability; and realizing sustainable development.
Cardiac‐specific experiential avoidance predicts change in general psychological well‐being among patients completing cardiac rehabilitation
Authors: Spatola Chiara A.M. , Giusti Emanuele Maria , Rapelli Giada , Goodwin Christina , Cattivelli Roberto , Pietrabissa Giada , Malfatto Gabriella , Facchini Mario , Castelnuovo Gianluca , Molinari Enrico 
Published: April 2021

AbstractPrevious studies have shown that experiential avoidance (EA) is associated with physical and psychological well‐being in medical and non‐medical samples. The aims of the present study were to evaluate the reciprocal association between psychological well‐being and EA over time among cardiac rehabilitation (CR) patients with moderately to severely low levels of psychological well‐being. Pre‐CR data on demographic characteristics, measures of psychological well‐being, and cardiac‐specific EA were collected from 915 CR patients, as well as post‐CR psychological well‐being and EA data, from 800 of these patients. A cross‐lagged model was estimated to examine the relationship between EA and psychological well‐being among patients with moderately to severely low levels of psychological well‐being based on questionnaire scores. Both EA and psychological well‐being significantly changed during CR and were negatively associated with each other at both pre‐ and post‐CR. Results from cross‐lagged structural equation modeling supported a nonreciprocal association between EA and psychological well‐being during CR. Pre‐CR assessment of EA in patients showing low levels of well‐being at the beginning of CR could help to identify patients at risk for worse psychological outcomes. EA could be a promising target of psychological treatments administered during CR.