bluuebunny/crossref_metadata_2025_split huggingface dataset:
Macrophage-Derived Osteopontin Influences the Amplification of Cryptococcus neoformans–Promoting Type 2 Immune Response
Authors: Hansakon Adithap , Png Chin Wen , Zhang Yongliang , Angkasekwinai Pornpimon 
Published: September 2021

Abstract
A multifunctional glycoprotein, osteopontin (OPN), can modulate the function of macrophages, resulting in either protective or deleterious effects in various inflammatory diseases and infection in the lungs. Although macrophages play the critical roles in mediating host defenses against cryptococcosis or cryptococcal pathogenesis, the involvement of macrophage-derived OPN in pulmonary infection caused by fungus Cryptococcus has not been elucidated. Thus, our current study aimed to investigate the contribution of OPN to the regulation of host immune response and macrophage function using a mouse model of pulmonary cryptococcosis. We found that OPN was predominantly expressed in alveolar macrophages during C. neoformans infection. Systemic treatment of OPN during C. neoformans infection resulted in an enhanced pulmonary fungal load and an early onset of type 2 inflammation within the lung, as indicated by the increase of pulmonary eosinophil infiltration, type 2 cytokine production, and M2-associated gene expression. Moreover, CRISPR/Cas9–mediated OPN knockout murine macrophages had enhanced ability to clear the intracellular fungus and altered macrophage phenotype from pathogenic M2 to protective M1. Altogether, our data suggested that macrophage-derived OPN contributes to the elaboration of C. neoformans–induced type 2 immune responses and polarization of M2s that promote fungal survival and proliferation within macrophages.
Diagnostic accuracy and feasibility of portable sleep monitoring in patients with obstructive sleep apnea: Re-exploring the utility in the current COVID-19 pandemic
Authors: Gupta Mansi , Ish Pranav , Chakrabarti Shibdas , Sen Manas Kamal , Mishra Prabhakar , Suri Jagdish Chander 
Published: September 2021

Portable sleep monitoring (PSM) is a promising alternative diagnostic tool for Obstructive Sleep Apnea (OSA) especially in high burden resource limited settings. We aimed to determine the diagnostic accuracy and feasibility of PSM device-based studies in patients presenting for evaluation of OSA at a tertiary care hospital in North-India. PSM studies (using a Type-III PSM device) were compared for technical reliability and diagnostic accuracy with the standard laboratory-based Type-I polysomnography (PSG). Patients were also interviewed about their experience on undergoing an unsupervised PSM studies. Fifty patients (68% males) were enrolled in the study, of which only 30% patients expressed their concerns about undergoing unsupervised PSM studies which included safety issues, ease of use, diagnostic accuracy, etc. Technical acceptability criteria were easily met by the PSM studies with signal loss in 12% studies (complete data loss and inaccessible data in 6% studies), warranting repetition sleep studies in four patients. The overall sensitivity of PSM device (AHI ≥5) was 93.5% (area under curve; AUC: 0.87). The diagnostic accuracy was 68.5%, 80%, and 91.4% for mild, moderate, and severe cases of OSA, respectively. An overall strong correlation was observed between PSM-AHI (apnoea-hypopnoea index) and PSG (r>0.85, p≤0.001), especially in severe OSA. The observed sensitivity was >90% for AHI>20 (clinically significant OSA), with high specificity of 91% for severe OSA (AUC: 0.94, 0.97 for AHI>20, AHI>30 respectively). The overall Bland-Altman concordance analysis also demonstrated only a small dispersion for PSM studies with a Cronbach’s coefficient of 0.95. Therefore, there is good diagnostic accuracy as well as feasibility of home-based portable sleep studies in Indian patients. It can be promoted for widespread use in high burden countries like India for diagnosing and managing appropriately selected stable patients with high clinical probability of OSA, especially during the ongoing crises of COVID-19 pandemic.
Assessment of knowledge and awareness among nursing students of a private medical university towards periodontal health and oral-systemic disease link
Authors: Verma Kanika , Dhruvakumar Deepa 
Published: September 2021

Background
Health is a global human demand for all strata of population. Oral health plays an essential role to conserve the overall general health. Many systemic conditions have been linked in association with periodontitis, such as preterm low birth weight infants, cardiovascular disease and related events such as angina, myocardial infarction, stroke, respiratory diseases, and diabetes mellitus. Education of oral health is considered to abide an essential prerequisite for oral health-related behavior. This survey was carried out to determine the level of knowledge and awareness about periodontal health and its oral-systemic disease link amongst the nursing students of private medical university.

Aim
To perceive an understanding among students of nursing college at private university on periodontal health and their knowledge about oral health and link of systemic disease with the help of a questionnaire survey.

Patients and methods
Three hundred and fifty nursing students were provided with a self-constructed 15 items questionnaire. χ
2 test was utilized for individual questions and Kruskal–Wallis test was applied to compare overall periodontal health awareness and awareness about oral-systemic link among students of nursing college.

Results and conclusion
A total of 350 questionnaires were distributed, out of which all 350 were completed by the students and evaluated for the study with an overall response of questions rate of 97%. The study indicated that 40% of the nursing students were having knowledge about the health of gums and oral hygiene maintenance. Thirty-seven percent were aware about the oral hygiene practices and 23% were familiar about the perio-systemic disease link. But 77% were unaware about the correlation between the periodontal health and systemic diseases.
Comparative study between different designs of maxillary implant assisted overdenture (in vitro study)
Authors: Makled Samar H. , Abd Elfatah Fadel A. , El-Guindy Mohamed N. 
Published: September 2021

Purpose
Evaluate microstrains on peri-implants tissue of different designs of maxillary complete overdenture assisted by different number of implants.

Methods
Two maxillary epoxy resin models used, for the first model two implants with 4.5 mm diameter and 13 mm length installed in the canine area and two implants with 4.5 mm diameter and 10 mm length installed in the second premolar area and two designs of maxillary overdenture used: group I maxillary implant overdenture (MIOD) assisted by four implants and Group (II) palateless maxillary implant overdenture assisted by four implants, for the second model two implants with 4.5 mm diameter and 13 mm length installed in the canine area and two designs of maxillary over denture used: group III MIOD assisted by two implants and group IV palateless implant overdenture assisted by two implants, four strain gauges used around each implant, bilateral static 100 N vertical load and 65 N oblique load applied on the occlusal surface of each MIOD. Stress meter used to measure the microstrains using software (ED × 10 A).

Results
The least stress found related to group I under 100 N vertical loading and the highest readings found related to group IV under 65 N oblique loading, under vertical loading stresses recorded in group III was greater than group I, stress in group IV was greater than group II, stress in group II was greater than group I, stress in group IV was greater than group III, under oblique loading, stress in group III was greater than group I, stress in group IV was greater than group II, stress in group II was greater than group I, stress in group IV was greater than group II.

Conclusion
Removing the palatal part from MIOD could be done in case of using four implants without damaging the prei-implants tissues.
Elegant Iterative Methods for Solving a Nonlinear Matrix Equation X-A* eX A=I
Authors: Chacha Chacha S 
Published: September 2021

The nonlinear matrix equation was solved by Gao (2016) via standard fixed point method. In this paper, three more elegant iterative methods are proposed to find the approximate solution of the nonlinear matrix equation namely: Newton’s method; modified fixed point method and a combination of Newton’s method and fixed point method. The convergence of Newton’s method and modified fixed point method are derived. Comparative numerical experimental results indicate that the new developed algorithms have both less computational time and good convergence properties when compared to their respective standard algorithms.
Keywords: Hermitian positive definite solution; nonlinear matrix equation; modified fixed point method; iterative method
Synthesis of 1-(2,4-Dinitrophenyl)-3,5-diphenyl-1H-pyrazol-4-ol via trans-1,3-Diphenyl-2,3-epoxy-1-propanone
Authors: Ovonramwen Oluwaseyi B 
Published: September 2021

The trans-1,3-diphenyl-2,3-epoxy-1-propanone was synthesized from benzaldehyde and 2-bromoacetophenone in 20 min which is more economical. The presence of ethanol and Br in 2-bromoacetophenone facilitated the reaction. The vicinal diaxial coupling constant of trans-1,3-diphenyl-2,3-epoxy-1-propanone was zero, an indication of trans configuration for a rigid 3-membered ring at ~90o dihedral angle. 1-(2,4-Dinitrophenyl)-3,5-diphenyl-1H-pyrazol-4-ol was synthesized from trans-1,3-diphenyl-2,3-epoxy-1-propanone and 2,4-dinitro phenylhydrazine in glacial CH3COOH to give 85.5% yield and characterized using FTIR, 1H, 13C NMR, DEPT 135 and MS spectra. The 1-(2,4-dinitrophenyl)-3,5-diphenyl-1H-pyrazol-4-ol can be exploited for unique biological activities and in the synthesis of synthetic fibers.
Keywords: 1-(2,4-dinitrophenyl)-3,5-diphenyl-1H-pyrazol-4-ol, trans-1,3-diphenyl-2,3-epoxy-1-propanone; synthesis; 2,4-dinitro phenylhydrazine
Synthesis and Antimicrobial Activities of 1-((5-Chloro-1-ethyl-2-methyl-1H-imidazol-4-yl)sulfonyl)-N-ethylpyrrolidine-2-carboxamide
Authors: Ovonramwen Oluwaseyi B. , Owolabi Bodunde J. , Falodun Abiodun 
Published: September 2021

A new 1-((5-chloro-1-ethyl-2-methyl-1H-imidazol-4-yl)sulfonyl)-N-ethylpyrrolidine-2-carboxamide was synthesized from methyl-1-[(5-chloro-1-ethyl-2-methyl-1H-imidazol-4-yl)sulfonyl]pyrrolidine-2-carboxylate and ethylamine. The compound methyl-1-[(5-chloro-1-ethyl-2-methyl-1H-imidazol-4-yl)sulfonyl]pyrrolidine-2-carboxylate was synthesized from methyl pyrrolidine-2-carboxylate and 5-chloro-4-chlorosulfonyl-1-ethyl-2-methyl-imidazole. The compounds were characterized based on FTIR, 1H, 13C NMR, and DEPT 135 analysis. Antimicrobial activities of the 1-((5-chloro-1-ethyl-2-methyl-1H-imidazol-4-yl)sulfonyl)-N-ethylpyrrolidine-2-carboxamide against Gram-positive (methicillin-susceptible Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, and Bacillus subtilis), Gram-negative (Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae), and Candida albicans were carried out using the standard microbiological method. The newly synthesized 1-((5-chloro-1-ethyl-2-methyl-1H-imidazol-4-yl)sulfonyl)-N-ethylpyrrolidine-2-carboxamide had no activities against the tested organisms.
Keywords: 1-((5-chloro-1-ethyl-2-methyl-1H-imidazol-4-yl)sulfonyl)-N-ethylpyrrolidine-2-carboxamide; methyl-1-[(5-chloro-1-ethyl-2-methyl-1H-imidazol-4-yl)sulfonyl]pyrrolidine-2-carboxylate; L-proline; ethylamine.
Weighted Statistical A-optimal Designs for Two-variable Poisson Regression Model with Application to Fertility Studies
Authors: Olamide Emmanuel Idowu , Adebola Femi Barnabas , Fasoranbaku Olusoga Akin 
Published: September 2021

This research extends design optimization to model involving count data. A two-variable Poisson regression model was investigated for A-optimality on a constrained design space and the weights of the optimal design points were obtained. The constructed designs were verified to be A-optimal at 4-point design through the general equivalence theorem. The efficiency of the constructed optimal design was found to be 100% A-efficient. The concept of weighted optimal designs for Poisson regression model was applied to fertility studies. Approximate A-optimal design weights of educational level of women were obtained for each marriage duration period with respect to their places of residence. The study revealed that the numbers of women with secondary education and above were found to be consistently more than that of women with no education, lower primary education and upper primary education, respectively for all the marriage duration periods considered and at each place of residence. The only exclusion is the marriage duration of 0–4 years at Suva where the proportion of women with no education was more than other educational levels.
Keywords: A-optimality; Design Point; Fisher Information Matrix; Imperialist Competitive Algorithm; Poisson Regression Model
Potency of Dioscorea sansibarensis (Dioscoreaceae) Leaf Eluates on Callosobruchus chinensis, Linnaeus 1758 (Coleoptera: Bruchidae) in the Protection of Phaseolus vulgaris (Fabaceae)
Authors: Mauti Godfrey 
Published: September 2021

Post-harvest losses of stored Phaseolus vulgaris to the bean weevil Callosobruchus chinensis have reached levels of significant concern. Governments and health organisations propose the discovery of reliable, healthy and biodegradable pesticides with higher selectivity and a broad spectrum. This study presents investigations on the activities of Dioscorea sansibarensis leaf extracts on the mortality of C. chinensis and reduction of their egg-laying ability. Laboratory experiments under Completely Randomized Design (CRD) were carried out to determine the mortality and anti-oviposition activity of the vacuum liquid chromatography (VLC) eluates of n-hexane (HE), chloroform (CE), ethyl acetate (EE), n-butanol (BE) and methanol (BE) at different concentrations. Bioassay data were subjected to nonparametric statistical analysis and a generalized linear model at p = 0.05. Statistical results showed that the VLC eluates had a mortality activity of 88.01% (R2 = 0.8801). Treatment by 0.025 g of HE and 0.075 g of CE had 9.60 and 11.50, respectively at p = 0.181. These mortality records were high as to 0.1 g of ME, 0.05 g of EE and 0.075 g of BE that recorded 8.55, 8.45 and 7.80, respectively. Treatments by 0.05 g of CE, 0.025 g of HE, 0.05 g of EE and the positive control recorded mortality of 10.50, 9.60, 8.45 and 8.35, respectively. The highest mortality was observed in the treatment by 0.075 g of HE and 0.1 g of HE with 12.85 and 13.70, respectively at p = 0.377. The VLC eluates had an anti-oviposition activity of 24.98% (R2 = 0.2498) on the C. chinensis. The generalized linear model reported Wald Chi-Square values of 4.363; p = 0.037, 0.711; p = 0.399, 9.125; p = 0.003, 4.363; p = 0.037 on the treatment by 0.025 g of CE, 0.05 g of EE, 0.075 g of BE and 0.1 g of ME, respectively. At p = 0.051, 0.1 g of CE and the positive control attained oviposition of 89.25 and 96.75 respectively. The study presents the first documentation of the lethal activity of D. sansibarensis on the C. chinensis pulse beetle. This could help in the development of Integrated Pest Management (IPM) and could help in the elimination or suppression of the infestation.
Keywords: anti-oviposition, Callosobruchus chinensis, Dioscorea sansibarensis leaf, mortality, Phaseolus vulgaris, vacuum liquid chromatography (VLC) eluates.
Prospects for improving the quality of professional education
Authors: Edokova T. N. 
Published: September 2021

The current problems arising in the implementation of the educational process in institutions of secondary vocational education are considered: self-determination of applicants, their interest in obtaining a specific specialty; the qualifications of the teaching staff, their professionalism and dedication; material and technical equipment of classrooms, laboratories and workshops. These indicators are reflected in the quality of the provision of educational services, the qualifications of graduates, the rating of the educational institution.The purpose of the study, based on many years of pedagogical experience of working with students and in the teaching and methodological department of secondary vocational education, is to draw attention to the accumulated issues in the secondary vocational education system, which are largely due not only to financial difficulties, but also from inconsistency of actions within the teaching staff.Analyzing the downward trend in the quality of education, possible ways of changing the situation that require a professional approach have been identified.Effective functioning of the psychological and pedagogical service of educational institutions; motivation of applicants to obtain a specialty; competent work of curators with students' parents; mentoring activities of experienced teachers with young teachers; attentive attitude to the organization of the lesson — as the main activity of the teacher; correct analysis of regulatory documents; competent development of educational documentation; modern equipment of classrooms, laboratories, workshops — this is only a partial solution to many problems.The results of the research can be useful for teaching staff of secondary vocational schools when organizing a system for training qualified workers and mid-level specialists.
Analysis of changes in the layout of the educational standard of secondary vocational education
Authors: Stanulevich O. E. 
Published: September 2021

Today, changes are being made to the main regulatory documents in the field of education, which require a revision of the structure and content of federal state standards. In addition, the labor market requires synchronization of content with the requirements of specific industries. All this required a revision of the layout of the standard for secondary vocational education. Today, 100 educational standards are already in development.For the study, an analysis of the current federal state educational standards and their changes since their introduction in the system of secondary vocational education was carried out. And also considered the latest changes in the regulatory framework of secondary vocational education. Based on the method of analysis, the main changes in the structure and content of federal educational standards were identified. On the basis of the modeling method, the directions of changes in the approximate basic educational programs were determined.The changes identified in the course of the study will allow educational organizations to more successfully apply these standards in the development of basic educational programs.Changes in the vocational education system associated with the approbation of a new layout will allow the education system to respond to the dynamically changing demands of the labor market and provide training for workers who meet the modern requirements of the economy.
The history of transport education in the exhibits of the Museum of the Russian University of Transport
Authors: Kulikova E. B. 
Published: September 2021

One of the oldest transport universities in the country — the Russian University of Transport (RUT (MIIT)) — is 125 years old. The history of the university and transport education in general is reflected in the expositions of the university museum.The main historical periods of the development of the museum, starting from 1896, are noted: tsarist Russia, the soviet period until the Great Patriotic war of 1941-1945, the war and post-war years, the post-soviet period.The RUT Museum (MIIT), being the same age as the university, today is one of the oldest museums in Moscow. The collections of items collected in its funds are striking in their diversity and uniqueness. The museum has over 12,000 items, 7,000 of which are on permanent display for visitors. All cultural heritage sites are inextricably linked with the rich history of the university and the history of Russia. Most of the museum's collection is traditionally collected thanks to the help and support of the university staff, as well as its graduates from different years, who honor the traditions of the Alma mater and carefully preserve the history of the university for posterity.Taking into account the specifics of the museum, it is obvious that the number and themes of its expositions will only expand over time, which means that it will not lose its relevance for a very long time and will be of interest to guests of all ages and professions.
100th anniversary of the main "locomotive" of the Orenburg region
Authors: Aleksenko M. A. 
Published: September 2021

The strategy of socio-economic development of the Orenburg region until 2020 and for the period until 2030 provides for a number of transformations in the region based on the natural resource potential, polycentric settlement system, favorable geopolitical position, transit potential of the Orenburg region. A special emphasis in the Strategy is placed on the development of railway transport, overland Eurasian international transport corridors. The unique geopolitical position of the Orenburg region necessitated the presence of a developed railway transport network in this region and, accordingly, the training of appropriate personnel.The history of one of the oldest educational institutions of the Orenburg region — the Orenburg Technical School of Railway Transport is considered.Archival materials, published sources (periodicals, Internet resources), personal memoirs of teachers, employees and students of Orenburg Technical School of Railway Transport were used. Methods of historicism, consistency, analysis are applied.The creation of Orenburg Technical School of Railway Transport, the position of the technical school in the difficult 1920s, during the Great Patriotic War and the post-war period, the expansion of the educational institution and the change of its location, the current state of the technical school and its potential are shown.Today, we can say with complete confidence that Orenburg Technical School of Railway Transport is a kind of "locomotive" that provides highly qualified personnel to a strategically important region of Russia and the development of railway transport in the region.