bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of senescence‐associated gene101 (PagSAG101a) in the regulation of secondary xylem formation in poplar
Authors: He Hui , Song Xue‐Qin , Jiang Cheng , Liu Ying‐Li , Wang Dian , Wen Shuang‐Shuang , Chai Guo‐Hua , Zhao Shu‐Tang , Lu Meng‐Zhu 
Published: November 2021

AbstractWood is produced by the accumulation of secondary xylem via proliferation and differentiation of the cambium cells in woody plants. Identifying the regulators involved in this process remains a challenging task. In this study, we isolated PagSAG101a, the homolog of Arabidopsis thaliana SAG101, from a hybrid poplar (Populus alba × Populus glandulosa) clone 84K and investigated its role in secondary xylem development. PagSAG101a was expressed predominantly in lignified stems and localized in the nucleus. Compared with non‐transgenic 84K plants, transgenic plants overexpressing PagSAG101a displayed increased plant height, internode number, stem diameter, xylem width, and secondary cell wall thickness, while opposite phenotypes were observed for PagSAG101a knock‐out plants. Transcriptome analyses revealed that differentially expressed genes were enriched for those controlling cambium cell division activity and subsequent secondary cell wall deposition during xylem formation. In addition, the tandem CCCH zinc finger protein PagC3H17, which positively regulates secondary xylem width and secondary wall thickening in poplar, could bind to the promoter of PagSAG101a and mediate the regulation of xylem differentiation. Our results support that PagSAG101a, downstream of PagC3H17, functions in wood development.
The Empirical Relevance of the Shadow Rate and the Zero Lower Bound
Authors: ELLINGTON MICHAEL 
Published: November 2021

AbstractThis paper investigates the evolution of unconventional monetary policies under a binding zero lower bound (ZLB) constraint for the U.S. economy. In doing so, this study provides a comprehensive empirical assessment on the economic and statistical implications of allowing conventional and unconventional monetary policies to work in mutually exclusive union using shadow rates. Shadow rate Taylor rules and policy counterfactuals implied by time‐varying coefficient structural vector autoregression (VAR) models show: (i) one can reconcile plausible economic results using shadow rates when short‐term interest rates approach the ZLB and (ii) unconventional monetary policies are a viable response to recession and facilitate stability during economic recovery.
Effects of nurse‐led nonpharmacological pain interventions for patients with cancer: A systematic review and meta‐analysis
Authors: Park Youn Jin , Lee Myung Kyung 
Published: November 2021

AbstractPurposeThe purposes of this study were to review the types of nurse‐led nonpharmacological pain interventions (NPI) offered to cancer patients and/or family caregivers, and to determine a comprehensive and robust estimate of the effect size of nurse‐led NPI for cancer patients on various pain‐related outcomes.DesignSystematic review and meta‐analysis. Studies assessing nurse‐led NPIs targeting cancer patients and published between January 2008 and December 2020 were identified by searching multiple literature databases, including MEDLINE®, EMBASE, Google Scholar, Cochrane Library, ProQuest Medical Library, and CINAHL®.MethodsThis review was conducted in accordance with the Preferred Reporting Item for Systematic Reviews and Meta‐analyses guidelines. The selected randomized clinical trials were independently assessed for methodological quality. The effect sizes (ESs) of treatment were presented as standardized mean differences (Hedges’ g) and 95% confidence intervals (CIs).FindingsA meta‐analysis was performed to analyze data from 22 randomized clinical trials. Three types of nurse‐led NPI were offered, mainly to cancer patients but also to some caregivers: music, physical, and psycho‐educational interventions. The dose and duration of nonpharmacological interventions varied widely. The study participants ranged in age from 44.1 to 67.3 years. Meta‐analysis indicated that, although these interventions had small effects in long‐term (g = 0.24, 95% CI: 0.06–0.43, p = 0.011) to medium effects in short‐term (g = 0.43, 95% CI: 0.32–0.53, p < 0.001), they significantly reduced patients’ pain, increased their knowledge of pain management, reduced barriers to pain management and pain coping, and improved other physical and emotional symptoms. The significance of the ES differed according to the type of intervention, with psycho‐educational and physical NPIs having a significant but medium short‐term ES, whereas music NPI had a significant but large short‐term ES. Only psycho‐educational NPIs had significant long‐term effects.ConclusionThe combined ES showed that these nurse‐led NPIs were significantly effective in both the short and long‐term. Types of intervention as a potential moderator were associated with short‐term and long‐term effects of nonpharmacological interventions on patient outcomes.Clinical relevanceResearch‐tested interventions should be provided to help patients cope effectively with pain.
The impact of self‐selected short sleep on monetary risk taking
Authors: Dickinson David L. , Brookes Jama , Ferguson Cori , Drummond Sean P. A. 
Published: November 2021

SummaryRisky choice has been widely studied in experimental settings, but there is a paucity of research examining the effects of self‐selected sleep schedules on risky choices. The current study examined incentivised risky choices of 100 young, healthy adults whose self‐selected (at‐home) sleep schedules were tracked via actigraphy for 1 week prior to decision making. Average nightly sleep was 6.43 h/night. On each trial of the decision task, individuals chose between two monetary gambles, with separate blocks of trials presenting amounts to gain versus amounts to lose for each paired gamble choice. In general, participants were risk‐averse when trying to maximise gains (GAINS) and risk‐seeking when trying to minimise losses (LOSSES). These tendencies were amplified in trials where gambles differed more (vs less) in their riskiness. Response times were longer for real choices (vs. dummy trials of random choice), LOSS versus GAINS trials, and when gambles were more similar versus different in risk. Gamble choices were not impacted by actigraphy measured average sleep levels, which suggests self‐selected moderate sleep deprivation does not affect risky monetary choices, as has been found in studies of experimentally induced sleep deprivation. However, our data showed that sleep variability increased risk‐taking behaviour in the LOSS condition. Thus, risky decision‐making may relate more to variability in sleep efficiency than to overall sleep duration or quality in naturalistic settings. The current study gives insight into how decision making in experimental sleep settings may or may not translate to more ecologically valid settings of self‐directed sleep.
Binge drinking induces an acute burst of markers of hepatic fibrogenesis (PRO‐C3)
Authors: Torp Nikolaj , Israelsen Mads , Nielsen Mette J. , Åstrand Claus P. , Juhl Pernille , Johansen Stine , Hansen Camilla D. , Madsen Bjørn , Villesen Ida F. , Leeming Diana J. , Thiele Maja , Hansen Torben , Karsdal Morten , Krag Aleksander 
Published: November 2021

AbstractBackground & AimsBinge drinking is associated with an increased risk of liver disease. Morbidity and mortality of alcohol‐related liver disease (ALD) is associated with collagen deposition in the hepatic extracellular matrix (ECM). However, the acute effects of binge drinking on ECM turnover are unknown. We aimed to investigate the effects on hepatic ECM turnover following a binge drinking episode.MethodsWe performed a pathophysiological intervention study with 15 non‐alcoholic fatty liver disease (NAFLD) patients, 15 ALD patients and 10 healthy controls. We used 40% ethanol in 9 mg/mL NaCl administered through a nasogastric tube to simulate binge drinking. Hepatic vein catheterisation allowed simultaneous hepatic‐ and systemic vein sampling. Markers of ECM formation and degradation were measured with competitive ELISA.ResultsThe interstitial matrix formation marker PRO‐C3 increased by 1.2 ng/mL (10%, P < .001) 24 hours after binge drinking. In participants with existing liver fibrosis determined by elevated baseline PRO‐C3, hepatic levels increased by 0.09 ng/mL (95% CI: 0.03‐0.15, P = .005) while systemic PRO‐C3 decreased 0.11 ng/mL (95% CI: −0.15 to −0.06, P < .001) in 3 hours. PRO‐C8 increased by 30% (+0.9 ng/mL, P = .014) in liver‐diseased patients with F0‐F1 but not in any other group. Twenty‐four‐hour changes in systemic C3M and PRO‐C3 were not associated (P = .911).ConclusionsBinge drinking induced an acute burst of PRO‐C3 in healthy individuals and patients with liver disease. Markers of ECM degradation were not correlated to markers of ECM formation, suggesting that even a single episode of binge drinking promotes excessive hepatic fibrogenesis.
State of the art treatment of hepatitis B virus hepatocellular carcinoma and the role of hepatitis B surface antigen post‐liver transplantation and resection
Authors: Schemmer Peter , Burra Patrizia , Hu Rey‐Heng , Hüber Christian M. , Loinaz Carmelo , Machida Keigo , Vogel Arndt , Samuel Didier 
Published: November 2021

AbstractChronic hepatitis B virus (HBV) infection is the major aetiology of hepatocellular carcinoma (HCC). The optimal goal of therapy, hepatitis B surface antigen (HBsAg) loss and anti‐HBs production, is achieved rarely and HBsAg‐associated HCC risk is well recognized. Here we review the role of HBsAg in HCC, the link between HBsAg and HCC recurrence post‐liver transplantation or resection, and the implications for therapy. HBV‐associated carcinogenesis is a multifactorial process. The observation that HBV‐related HCC can occur in the absence of cirrhosis is compatible with a direct oncogenic effect of the virus, which may occur via multiple mechanisms, including those mediated by both mutated and unmutated HBsAg. HCC recurrence in HBsAg‐positive patients post‐liver transplantation has been reported in 10%‐15% of patients and is likely to be because of expansion of residual HCC tumour cell populations containing integrated HBV DNA, which expand and independently replicate HBV, leading to the recurrence of both HCC and HBV. The direct role of HBsAg in HCC recurrence post‐liver resection is less clear. Cirrhosis is the most important risk factor for HCC development, and precancerous cirrhotic liver remains after resection, with the potential to undergo malignant transformation regardless of the existence of HBV‐derived oncogenic drivers. The role of HBsAg in the development of HCC and its recurrence post‐surgical intervention has multiple implications for therapy and suggests a potential role for immunotherapy in the future management of HCC, in particular post‐liver transplantation. Use of hepatitis B immunoglobulins that target HBsAg directly, alongside immune‐oncology therapies, may be relevant in this setting.
Entangled Interdependence: Sign Language Interpreting without Recognition in India and Vietnam
Authors: Marie Aron , Friedner Michele 
Published: November 2021

AbstractDisabled people have achieved more legal recognition from nation‐states and societies because of advocacy and institutional efforts such as the United Nations Convention on the Rights of Persons with Disabilities. This is a starting, not an end, point: How does legal recognition trickle down (or not) or become distributed to those who work with disabled people? This article examines this question by ethnographically attending to the experiences of two sign language interpreters in Bangalore, India, and in Hà Nội, Vietnam. While both countries recognize deaf peoples’ rights, there is limited institutional or financial recognition of interpreters. Interpreters’ daily lives and individual projects of recognition are shaped by broader socio‐political contexts. The article argues that in the absence of legal recognition, recognition is an interpersonal process that is both produced by and produces forms of relationship and responsibility. How do interpreters seek and receive recognition from the state as well as deaf people, hearing colleagues, and society at large? Attending to recognition projects highlights how deaf people and interpreters are bound together in mutual systems of precarious interdependence. Recognition is negotiated across multiple scales and influences individuals’ life projects and livelihoods. [recognition, disability, deafness, sign language, interpreting]
Extended red blood cell matching for all transfusion recipients is feasible
Authors: van Sambeeck Joost H. J. , van der Schoot C. Ellen , van Dijk Nico M. , Schonewille Henk , Janssen Mart P. 
Published: November 2021

AbstractObjectiveTo demonstrate the feasibility and effectiveness of extended matching of red blood cells (RBC) in practice.BackgroundAt present, alloimmunisation preventing matching strategies are only applied for specific transfusion recipient groups and include a limited number of RBC antigens. The general assumption is that providing fully matched RBC units to all transfusion recipients is not feasible. In this article we refute this assumption and compute the proportion of alloimmunisation that can be prevented, when all donors and transfusion recipients are typed for A, B, D plus twelve minor blood group antigens (C, c, E, e, K, Fya, Fyb, Jka, Jkb, M, S and s).MethodsWe developed a mathematical model that determines the optimal sequence for antigen matching. The model allows for various matching strategies, issuing policies and inventory sizes.ResultsFor a dynamic inventory composition (accounting for randomness in the phenotypes supplied and requested) and an antigen identical issuing policy 97% and 94% of alloimmunisation events can be prevented, when respectively one and two RBC units per recipient are requested from an inventory of 1000 units. Although this proportion decreases with smaller inventory sizes, even for an inventory of 60 units almost 50% of all alloimmunisation events can be prevented.ConclusionIn case antigen of both donors and recipients are comprehensively typed, extended preventive matching is feasible for all transfusion recipients in practice and will significantly reduce transfusion‐induced alloimmunisation and (alloantibody‐induced) haemolytic transfusion reactions.
Ideologies of English‐medium instruction in Vietnam
Authors: Tri Dang H. 
Published: November 2021

AbstractThis study seeks to conduct a multi‐layered examination of language ideologies in English‐medium instruction (EMI) education anchored in policy documents and relevant stakeholders’ discourse in Vietnam. Research data were based on national and institutional policies and interviews with ten university administrators, 15 content lecturers, and five focus groups of six students. The findings indicate that EMI is ideologically embraced as producing different forms of capital, including linguistic, cultural, economic, and social capital, all of which have enormous potential for the cause of national socio‐economic development, internationalization of higher education, and individual future employability. However, the study demonstrates that the way EMI is celebrated and glorified as access to supreme quality education unexpectedly gives it symbolic power and undoubtedly downgrades the mother tongue as a medium of instruction. The study is concluded with implications and recommendations for further research on language ideologies in EMI education.
Hypercalcaemia inMycobacterium kansasiipulmonary infection
Authors: Flowers Robert Costigan , Ocampo Javier , Krautbauer Justin , Kupin Warren L 
Published: November 2021

A gentleman in his 60s with end-stage kidney disease status post kidney transplantation on prednisone and tacrolimus presented with generalised weakness for 7 days, associated with altered mental status. Investigations revealed pancytopenia, acute kidney injury, hypercalcaemia, decreased parathyroid hormone (PTH) and normal calcitriol levels. CT of the chest showed multifocal lung opacities suspicious for malignancy. Bronchoscopy with biopsy yielded no malignant cells, and bronchoalveolar lavage specimens grewMycobacterium kansasii. The patient was treated with bisphosphonates, calcitonin and antibiotics for non-tuberculous mycobacteria pulmonary infection, with improvement in serum calcium levels, and was discharged after 5 weeks of hospitalisation.The work-up for hypercalcaemia begins with PTH measurement, and low PTH levels are consistent with malignancy, immobilisation and granulomatous diseases. Hypercalcaemia in the lattermost is classically caused by overproduction of calcitriol by activated macrophages. However, there are case reports of mycobacterial infections with hypercalcaemia despite normal calcitriol levels, supporting the existence of an additional mechanism of hypercalcaemia in granulomatous infections.
Regional and socioeconomic disparities in cardiovascular disease in Canada during 2005–2016: evidence from repeated nationwide cross-sectional surveys
Authors: Dai Haijiang , Tang Biao , Younis Arwa , Kong Jude Dzevela , Zhong Wen , Bragazzi Nicola Luigi 
Published: November 2021

IntroductionThe objective of this study is to examine the temporal trends and patterns of regional and socioeconomic disparities in cardiovascular disease (CVD) in Canada during 2005–2016.MethodsA total of 670 000 adults aged ≥20 years who participated in the Canadian Community Health Surveys between 2005 and 2016 were enrolled for this study. CVD referred to heart disease and stroke in this study. Equivalised household income was used as a proxy of socioeconomic status. Absolute and relative socioeconomic inequalities were measured by slope index of inequality (SII) and relative index of inequality (RII), respectively.ResultsIn 2015/2016, the overall age-adjusted and sex-adjusted prevalence of heart disease and stroke was 4.80% (95% CI 4.61% to 4.98%) and 1.25% (95% CI 1.13% to 1.36%), respectively. Trend analyses suggested a significant decline in the age-adjusted and sex-adjusted prevalence of heart disease (P for trend <0.001) and a non-significant decline in the age-adjusted and sex-adjusted prevalence of stroke (P for trend=0.058) from 2005 to 2016. Nevertheless, the total number of adults suffering from heart disease and stroke increased by 8.9% and 20.2% over the study period, respectively. Moreover, the age-adjusted and sex-adjusted prevalence of heart disease and stroke varied widely across all health regions, and both of them tended be higher among those with lower income. The SII and RII indicated that there were persistent absolute and relative socioeconomic inequalities in heart disease and stroke across all surveys (eg, SII for heart disease in both sexes, 2005: 0.04 (95% CI 0.03 to 0.04); 2015/2016: 0.03 (95% CI, 0.02 to 0.04); RII for heart disease in both sexes, 2005: 1.99 (95% CI 1.75 to 2.27); 2015/2016: 1.77 (95% CI 1.52 to 2.08).ConclusionGeographical and socioeconomic disparities should be taken into account during the further efforts to strengthen preventive measures and optimise healthcare resources for heart disease and stroke in Canada.
Cooperation evolves by the payoff-difference-based probabilistic reward
Authors: Ohdaira Tetsushi 
Published: November 2021

Abstract
In the previous studies, the author proposes the payoff-difference-based probabilistic peer-punishment that the probability of punishing a defector increases as the difference of payoff between a player and a defector increases and shows that the proposed peer-punishment effectively increases the number of cooperators and the average payoff of all players. On the other hand, reward as well as punishment is considered to be a mechanism promoting cooperation, and many studies have discussed the effect of reward in the public goods game, a multiplayer version of the prisoner’s dilemma game. Based on the discussion of those existing studies, this study introduces the payoff-difference-based probabilistic reward that the probability of rewarding a cooperator increases as the difference of payoff between a player and a cooperator increases. The author utilizes the framework of the spatial prisoner’s dilemma game of the previous study and shows that the reward of this study realizes the evolution of cooperation except some cases.

Graphic abstract
Gravitational and electromagnetic radiation from binary black holes with electric and magnetic charges: elliptical orbits on a cone
Authors: Liu Lang , Christiansen Øyvind , Ruan Wen-Hong , Guo Zong-Kuan , Cai Rong-Gen , Kim Sang Pyo 
Published: November 2021

AbstractExtending the electromagnetic and gravitational radiations from binary black holes with electric and magnetic charges in circular orbits in Liu et al. (Phys. Rev. D 102:103520, 2020), we calculate the total emission rates of energy and angular momentum due to gravitational and electromagnetic radiations from dyonic binary black holes in precessing elliptical orbits. It is shown that the emission rates of energy and angular momentum due to gravitational and electromagnetic radiations have the same dependence on the conic angle for different orbits. Moreover, we obtain the evolutions of orbits and find that a circular orbit remains circular while an elliptic orbit becomes quasi-circular due to electromagnetic and gravitational radiations. Using the evolution of orbits, we derive the waveform models for dyonic binary black hole inspirals and show the amplitudes of the gravitational waves for dyonic binary black hole inspirals differ from those for Schwarzschild binary black hole inspirals, which can be used to test electric and magnetic charges of black holes.
Study of theoretical luminosity precision for electron colliders at higher energies
Authors: Jadach S. , Płaczek W. , Skrzypek M. , Ward B. F. L. 
Published: November 2021

AbstractWe present an estimation of the theoretical precision of low angle Bhabha scattering at the proposed future ILC collider at 500 GeV. The analysis is an extension of the previous analysis done for the FCCee collider at $$\sqrt{s}=M_Z$$

s

=

M
Z

. As the state-of-the-art and the reference point we use the Monte Carlo event generator. Based on the current precision status of for LEP analysis, we estimate how various error components evolve from the LEP to ILC setups. The conclusion of our work is that for the ILC the precision of the current version of 4.04 deteriorates to 0.5%, by more than an order of magnitude w.r.t. the present precision for LEP. With the expected future improvements, the precision of can change to 0.016%, nearly as good as for the FCCee at the $$M_Z$$

M
Z

setup (0.01%). Based on the developed methodology we present also results for ILC$$_{1000}$$

1000

, FCCee$$_{350}$$

350

and CLIC$$_{3000}$$

3000

setups.
Correlation and combination of sets of parton distributions
Authors: Ball Richard D. , Forte Stefano , Stegeman Roy 
Published: November 2021

AbstractWe study the correlation between different sets of parton distributions (PDFs). Specifically, viewing different PDF sets as distinct determinations, generally correlated, of the same underlying physical quantity, we examine the extent to which the correlation between them is due to the underlying data. We do this both for pairs of PDF sets determined using a given fixed methodology, and between sets determined using different methodologies. We show that correlations have a sizable component that is not due to the underlying data, because the data do not determine the PDFs uniquely. We show that the data-driven correlations can be used to assess the efficiency of methodologies used for PDF determination. We also show that the use of data-driven correlations for the combination of different PDFs into a joint set can lead to inconsistent results, and thus that the statistical combination used in constructing the widely used PDF4LHC15 PDF set remains the most reliable method.