bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction
Authors: VanDusen Keith W. , Li Yi-Ju , Cai Victor , Hall Ashley , Hiles Sarah , Thompson J. Will , Moseley M. Arthur , Cooter Mary , Acker Leah , Levy Jerrold H. , Ghadimi Kamrouz , Quiñones Quintin J. , Devinney Michael J. , Chung Stacey , Terrando Niccolò , Moretti Eugene W. , Browndyke Jeffrey N. , Mathew Joseph P. , Berger Miles ,   for the MADCO-PC Investigators
Published: March 2021

Background: Postoperative cognitive dysfunction (POCD), a syndrome of cognitive deficits occurring 1–12 months after surgery primarily in older patients, is associated with poor postoperative outcomes. POCD is hypothesized to result from neuroinflammation; however, the pathways involved remain unclear. Unbiased proteomic analyses have been used to identify neuroinflammatory pathways in multiple neurologic diseases and syndromes but have not yet been applied to POCD. Objective: To utilize unbiased mass spectrometry-based proteomics to identify potential neuroinflammatory pathways underlying POCD. Methods: Unbiased LC-MS/MS proteomics was performed on immunodepleted cerebrospinal fluid (CSF) samples obtained before, 24 hours after, and 6 weeks after major non-cardiac surgery in older adults who did ( n = 8) or did not develop POCD ( n = 6). Linear mixed models were used to select peptides and proteins with intensity differences for pathway analysis. Results: Mass spectrometry quantified 8,258 peptides from 1,222 proteins in > 50%of patient samples at all three time points. Twelve peptides from 11 proteins showed differences in expression over time between patients with versus without POCD (q < 0.05), including proteins previously implicated in neurodegenerative disease pathophysiology. Additionally, 283 peptides from 182 proteins were identified with trend-level differences (q < 0.25) in expression over time between these groups. Among these, pathway analysis revealed that 50 were from 17 proteins mapping to complement and coagulation pathways (q = 2.44*10–13). Conclusion: These data demonstrate the feasibility of performing unbiased mass spectrometry on perioperative CSF samples to identify pathways associated with POCD. Additionally, they provide hypothesis-generating evidence for CSF complement and coagulation pathway changes in patients with POCD.
Real-Word Experience of Cabozantinib in Metastatic Renal Cell Carcinoma (mRCC): Results from the Canadian Kidney Cancer information system (CKCis)
Authors: Zhang Hanbo , Basappa Naveen S. , Ghosh Sunita , Joy Isaiah , Lalani Aly-Khan A. , Hansen Aaron R. , Heng Daniel Y.C. , Castonguay Vincent , Kollmannsberger Christian K. , Winquist Eric , Wood Lori , Bjarnason Georg A. , Breau Rodney H. , Kapoor Anil , Graham Jeffrey 
Published: March 2021

BACKGROUND: Cabozantinib is an oral multitargeted tyrosine kinase inhibitor (TKI) that has demonstrated efficacy in metastatic renal-cell carcinoma (mRCC) randomized trials. OBJECTIVE: To explore the real-world effectiveness of cabozantinib in pretreated patients with mRCC, including patients who progressed on immune-oncology checkpoint inhibitor (ICI) therapy. METHODS: Using the Canadian Kidney Cancer information system (CKCis), patients with mRCC treated with cabozantinib monotherapy as second-line or later from January 1, 2011 to September 1, 2019 were identified. Patients were stratified based on line of cabozantinib received. We reported overall survival (OS), time to treatment failure (TTF) and disease control rate (DCR). Prognostic variables were analyzed using multivariable analysis. RESULTS: 157 patients received cabozantinib (median TTF 8.0 months; median OS 15.8 months): 37 (24%) in the second line (median TTF 10.4 months; median OS 18.9 months) 66 (42%) in third line (median TTF 5.9 months; median OS 13.3 months) and 54 (34%) in either 4th or 5th line (median TTF 9.4 months; median OS 16.8 months). One hundred sixteen patients (74%) received cabozantinib after prior ICI therapy (median TTF of 7.6 months; median OS of 15.8 months). DCR in all patients was 63% with 46%, 65% and 72% in 2nd line, 3rd line and 4th/5th line patients respectively. DCR in patients who received cabozantinib after prior ICI therapy was 64%. CONCLUSIONS: Cabozantinib is effective in a real-world, unselected population of mRCC patients, including in those who have progressed on prior ICI therapy, and in those exposed to multiple lines of therapy.
Predicting hypertensive disorders in pregnancy using multiple methods: Models with the placental growth factor parameter
Authors: Sun Ge , Xu Qi , Zhang Song , Yang Lin , Liu Guoli , Meng Yu , Chen Aiqing , Yang Yimin , Li Xuwen , Hao Dongmei , Liu Xiaohong , Shao Jing 
Published: March 2021

BACKGROUND: Placental growth factor (PlGF), one of the biomarkers, has a certain predictive effect on hypertensive disorders in pregnancy (HDP). OBJECTIVE: To study the HDP prediction effect of different methods for variable selection and modeling for models containing PlGF. METHODS: For the model containing PlGF, the appropriate range of PlGF parameters needed to be selected. Step-logistic regression and lasso were used to compare the model effect of twice range selection. The PlGF model with good predictive effect and appropriate detecting gestational age was selected for the final prediction. RESULTS: The effect of the model containing PlGF tested at 15–16 weeks was better than the PlGF value without comprehensive screening. The sensitivity of both methods was over 92%. By comprehensive comparison, the final model of lasso method in this study was more effective. CONCLUSIONS: In this study, a variety of methods were used to screen models containing PlGF parameters. According to clinical needs and model effects, the optimal HDP prediction model with PlGF parameters in the second trimester of 15–26 weeks of pregnancy was finally selected.
Notes from the Packaging Laboratory: Hot Tack Measurements of Thin Sealant Films
Authors: Berger Kenneth R. , Knoelke Matthew , Welt Bruce 
Published: March 2021

Sample preparation can greatly influence the results of laboratory testing of packaging sealant strength. Factors such as test strip width, edge uniformity, sealing die temperature and die load are recognizable variables to control. A design of experiments approach was used to explore the rank importance of these factors and any interactive effects that may occur. A generally well-behaved ethylene vinyl acetate (EVA) sealant on a high density polyethylene (HDPE) film was used for these tests. Experimental results indicate that sample width, die temperature and die pressure are the most influential factors. Unexpectedly, edge effects, namely a regular sine wave pattern and a generally random irregular edge had little influence on hot tack results. This document is ABE340, one of a series of the Agricultural and Biological Engineering Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. First published December 2002.
https://edis.ifas.ufl.edu/ae211
Field Corn Production Guide
Authors: Wright David , Marois Jim , Rich Jim , Sprenkel Richard 
Published: March 2021

Field corn is important in Florida for both grain and silage. Production has declined over the past two decades because of limited opportunities for profit, increased financial risks with less insurance coverage as compared to cotton and peanut, reduction in infrastructure for handling, and higher production costs. This is document SS-AGR-85, a publication of the Department of Agronomy, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. Publication Date: January 2004.
https://edis.ifas.ufl.edu/ag202
County Property Values and Tax Impacts of Florida's Citrus Industry
Authors: Hodges Alan W. , Mulkey W. David , Muraro Ronald P. , Spreen Thomas H. 
Published: March 2021

Events impacting the citrus industry, such as citrus canker or increased foreign competition due to liberalization of trade barriers, may have a dramatic impact on the welfare of local communities. This paper provides estimates of the local fiscal impacts of ad valorem property taxes paid by citrus grove owners, and taxes generated by citrus processing operations. This is EDIS document FE437, a publication of the Department of Food and Resource Economics, Florida Cooperative Extension Service, UF/IFAS, University of Florida, Gainesville, FL. Published November 2003.
FE437/FE437: County Property Values and Tax Impacts of Florida's Citrus Industry (ufl.edu)
Florida Solid and Hazardous Waste Regulation Handbook: Introduction
Authors: Olexa Michael T. , Leviten Aaron , Samek Kelly 
Published: March 2021

Current solid and hazardous waste law is a maze of statutes, regulations, and potential liabilities. This handbook is designed to act as your guide and as a first step in helping you recognize which agricultural and household activities may involve solid and hazardous wastes. It also provides an introduction to the agencies and statutes that govern solid and hazardous waste disposal. This is EDIS document FE441, a publication of the Department of Food and Resource Economics, Florida Cooperative Extension Service, UF/IFAS, University of Florida, Gainesville, FL. Published December 2003.
https://edis.ifas.ufl.edu/fe441
Florida Solid and Hazardous Waste Regulation Handbook: Overview
Authors: Olexa Michael T. , Leviten Aaron , Samek Kelly 
Published: March 2021

Federal law regulating the management of solid and hazardous wastes can be found in many different acts of Congress. The Resource Conservation and Recovery Act (RCRA) affects waste management, as does the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA). No single comprehensive federal law for solid and hazardous waste management exists, although RCRA touches on most of the major issues. This is EDIS document FE442, a publication of the Department of Food and Resource Economics, Florida Cooperative Extension Service, UF/IFAS, University of Florida, Gainesville, FL. Published December 2003.
https://edis.ifas.ufl.edu/fe442
The Future of Aging is Florida
Authors: Dwyer Jeffrey 
Published: March 2021

Currently, Florida ranks first in the United States in the percent of the population who is full-time and seasonal residents over the age of 65. Older Floridians, their families and communities face a myriad of issues related to aging. This document is FCS2209 FY624, one of a series of publications from the distance education in-service "Aging in the 21st Century." First published: September 2003.
FCS2209/FY624: The Future of Aging Is Florida (ufl.edu)
Mosquito Control Devices and Services for Florida Homeowners
Authors: Rutledge-Connelly C. Roxanne 
Published: March 2021

There are many devices on the market advertised to control mosquitoes. The advertisements for these devices are aimed at the average homeowner. How do you know if they will work? It is unfortunate that many advertisements take advantage of the concerns we have to protect family members from mosquito-borne disease. This factsheet is provided to assist homeowners in smart decision-making when it comes to protecting the health of you and your family. This document is ENY-692, one of a series of the Entomology & Nematology Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. First published: December 2003.
https://edis.ifas.ufl.edu/in171
Oriental Cockroach, Blatta orientalis Linnaeus (Insecta: Blattaria: Blattidae:)
Authors: McCanless Kim 
Published: March 2021

The origin of the oriental cockroach, Blatta orientalis Linnaeus, is uncertain, but it is thought to be from Africa or south Russia. It is a major household pest in parts of the northwest, mid-west, and southern United States. It is also sometimes referred to as the "black beetle" or a "water bug" because of its dark black appearance and tendency to harbor in damp locations. This document is EENY-159, one of a series of Featured Creatures from the Entomology and Nematology Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. Published: October 2000.
EENY159/IN316: Oriental Cockroach, Blatta orientalis Linnaeus (Insecta: Blattodea: Blattidae) (ufl.edu)
Melonworm, Diaphania hyalinata Linnaeus (Insecta: Lepidoptera: Pyralidae)
Authors: Capinera John L. 
Published: March 2021

Melonworm, Diaphania hyalinata Linnaeus, occurs throughout most of Central and South America and the Caribbean. The United States is the northern limit of its permanent range, and wintertime occurrence generally is limited to south Florida and perhaps south Texas. Melonworm disperses northward annually. Its distribution during the summer months is principally the southeastern states, though occasionally it disperses north to NewEngland and the Great Lakes region. This document is EENY-163, one of a series of Featured Creatures from the Entomology and Nematology Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. Published: October 2000.
EENY163/IN320: Melonworm, Diaphania hyalinata Linnaeus (Insecta: Lepidoptera: Crambidae) (ufl.edu)
Classical and Variant Avian Infectious Bronchitis Virus Strains
Authors: Butcher Gary D. , Shapiro David P. , Miles Richard D. 
Published: March 2021

Infectious bronchitis (IB) is an acute and highly contagious respiratory disease of chickens. The disease is characterized by respiratory signs including gasping, coughing, sneezing, tracheal râles, and nasal discharge. In young chickens, severe respiratory distress may occur. In layers, respiratory distress, decrease in egg production, and loss of internal egg quality and egg shell quality are reported. Some strains of the virus cause severe kidney damage and may be associated with high mortality. This document is VM127, one of a series of the Veterinary Medicine-Large Animal Clinical Sciences Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. Original publication date May 1, 2002.
VM127/PS039: Infectious Bronchitis Virus: Classical and Variant Strains (ufl.edu)
A DESCRIPTIVE STUDY OF MORPHOMETRIC DATA OF FEMORAL CONDYLES BY DIRECT METHOD TO DETERMINE DIFFERENCE ON RIGHT & LEFT SIDE IN RAJASTHAN REGION
Authors: Singh Jitendra , Chauhan Sangita , Saxena Dhiraj , Vijayvergiya Runjhun 
Published: March 2021

Background: There are no published studies on the anthropometry of the distal femur in the Indian population. Hence the results obtained from this study would provide valuable data on the average dimensions of the distal femur which can serve as guidelines for designing a suitable femoral component of total knee prostheses for this population.
Methods: After applying inclusion and exclusion criteria 41 dried femur of each side (total 82) of unknown age and sex will be selected for present study. The maximum anteroposterior distance & maximum transverse distance of lateral femoral condyle, maximum anteroposterior distance & maximum transverse distance of medial femoral condyle width was measured.
Results: In the present study the mean AP diameter of the medial condyle on right side was 54.55±6.88 mm and on left side was 54.36±3.56 mm, The mean Transverse diameter of the medial condyle was 27.33±3.09 mm and 25.03±1.99 mm on right and left side respectively. In AP diameter parameters no statistically significant difference found between right and left side because p value was >.05 for both parameters. But in Transverse diameter parameters are statistically significant found between right and left side because p value was <.05.
Conclusion: On comparison between right and left side measurements, no significant difference was found between values of parameters of right and left sided femur. This information will be useful to negate the need of side specific measurements for implant
Keywords: Femur, left, Right
Perfeccionismo e a relação com psicopatologias: Estudo integrativo
Authors: Rocha André Sousa 
Published: March 2021

O perfeccionismo é um traço latente psicológico que vem sendo compreendido de diferentes formas. Os avanços científicos e metodológicos na área sugerem que esse fenômeno possui componentes positivos e negativos. Esse estudo motivou-se pela questão problema levantada: quais as principais psicopatologias, na atualidade, relacionadas ao perfeccionismo? Algumas discussões são promovidas nesse ponto de vista. Para tanto, o presente artigo condensa, organiza e apresenta uma revisão integrativa consultada em bases nacionais e internacionais e visou investigar quais as principais psicopatologias relacionadas ao perfeccionismo. Desse modo, foram executadas buscas de artigos nas bases de dados Medline, Pubmed e Springer com os descritores perfeccionismo, psicopatologia, perfectionism e psychopathology ambos recrutados do DeCS e MeSH. Dos 226 artigos encontrados inicialmente, 213 foram descartados à medida que os critérios de inclusão e exclusão iam sendo aplicados. Desse modo, 13 artigos compuseram a amostra final. Os resultados indicaram que o perfeccionismo tem se relacionado com depressão, ansiedade, transtornos alimentares (bulimia e anorexia) bem como transtorno obsessivo compulsivo. Limitações e sugestões de futuros estudos são discutidos ao final.
EKSISTENSI HUKUM JAMINAN DALAM PROGRAM PEMULIHAN EKONOMI NASIONAL (PEN) PADA MASA PANDEMI COVID-19
Authors: Ernawati Elisatin , Syaifudin Ahmad 
Published: March 2021

Pelaksanaan program pemerintah dalam upaya Pemulihan Ekonomi Nasional sebagaimana yang telah dirumuskan dalam PP No. 23 / 2020, telah memasukkan program penjaminan sebagai salah satu skema yang berkontribusi dominan dalam keberhasilan program. Eksistensi hukum jaminan menjadi dipertanyakan sejauh mana dapat mengambil peran termasuk partisipasi Notaris dalam menjalan peran dan wewenangnya. Dalam penelitian ini penulis menggunakan metode penelitian yuridis normatif dengan memakai pendekatan konsep (conceptual approach), perundang-undangan (Statute Approach) dan pendekatan kasus (Case Approach). dari penelitian dapat disimpulkan bahwa jaminan dalam prespektif hukum jaminan membagi dalam bentuk jaminan kebendaan dan penanggungan telah berkembang dengan sangat cepat. Jaminan kebendaan yang membatasi nilai obyek jaminan berkembang sesuai dengan regulasi, sedangkan jaminan penanggungan (jaminan personal, korporasi) berkembang sesuai dengan perkembangan ekonomi dan bisnis. Keberadaan Notaris dalam kondisi apapun tetap mengambil peran sentral sesuai dengan tugas dan kewenangan terutama dalam merumuskan perjanjian pokok dan tambahan sebagai akta otentik yang mengikat para pihak.Kata kunci : PEN, Hukum Jaminan, Notaris Implementation of government programs in efforts to restore the National Economy as formulated in PP. 23/2020, has included the guarantee program as one of the schemes that have contributed dominantly to the success of the program. The existence of guarantee law becomes questionable to what extent it can take a role, including the participation of a notary in carrying out its functions and its authority. In this study the authors used a normative juridical research method using a conceptual approach, statutory approach and a case approach. From the research it can be concluded that guarantees in the perspective of security law divides into the form of property guarantees and coverage has grown very rapidly. Material guarantees that limit the value of the object of guarantee develop in accordance with regulations, while security guarantees (personal, corporate guarantees) develop according to economic and business developments. The existence of a Notary in any condition still plays a central role in accordance with the duties and authorities, especially in formulating the main and additional agreements as authentic deeds that bind the parties.Keywords: PEN, Guarantee Law, Notary
Thermodynamics and Kinetics of Sulfuric Acid Leaching Transformation of Rare Earth Fluoride Molten Salt Electrolysis Slag
Authors: Chen Lijie , Xu Jiacong , Yu Xiaoqiang , Tian Lei , Wang Ruixiang , Xu Zhifeng 
Published: March 2021

Rare earth element recovery in molten salt electrolysis is approximately between 91 and 93%, whereof 8% is lost in waste molten salt slag. Presently, minimal research has been conducted on the technology for recycling waste rare earth molten salt slag, which is either discarded as industrial garbage or mixed with waste slag into qualified molten salt. The development of a new approach toward the effective treatment of rare earth fluoride molten salt electrolytic slag, which can recycle the remaining rare earth and improve the utilization rate, is essential. Herein, weak magnetic iron separation, sulfuric acid leaching transformation, water leaching, hydrogen fluoride water absorption, and cycle precipitation of rare earth are used to recover rare earth from their fluoride molten salt electrolytic slag, wherein the thermodynamic and kinetic processes of sulfuric acid leaching transformation are emphatically studied. Thermodynamic results show that temperature has a great influence on sulfuric acid leaching. With rising temperature, the equilibrium constant of the reaction gradually increases, and the stable interval of NdF3 decreases, while that of Nd3+ increases, indicating that high temperature is conducive to the sulfuric acid leaching process, whereof the kinetic results reveal that the activation energy E of Nd transformation is 41.57 kJ/mol, which indicates that the sulfuric acid leaching process is controlled by interfacial chemical reaction. According to the Nd transformation rate equation in the sulfuric acid leaching process of rare earth fluoride molten salt electrolytic slag under different particle size conditions, it is determinable that with the decrease of particle size, the reaction rate increases accordingly, while strengthening the leaching kinetic process. According to the equation of Nd transformation rate in the sulfuric acid leaching process under different sulfuric acid concentration conditions, the reaction series of sulfuric acid concentration K = 6.4, which is greater than 1, indicating that increasing sulfuric acid concentration can change the kinetic-control region and strengthen the kinetic process.
A Machine Learning-Based Model to Predict Survival After Transarterial Chemoembolization for BCLC Stage B Hepatocellular Carcinoma
Authors: Lin Huapeng , Zeng Lingfeng , Yang Jing , Hu Wei , Zhu Ying 
Published: March 2021

ObjectiveWe sought to develop and validate a novel prognostic model for predicting survival of patients with Barcelona Clinic Liver Cancer Stages (BCLC) stage B hepatocellular carcinoma (HCC) using a machine learning approach based on random survival forests (RSF).MethodsWe retrospectively analyzed overall survival rates of patients with BCLC stage B HCC using a training (n = 602), internal validation (n = 301), and external validation (n = 343) groups. We extracted twenty-one clinical and biochemical parameters with established strategies for preprocessing, then adopted the RSF classifier for variable selection and model development. We evaluated model performance using the concordance index (c-index) and area under the receiver operator characteristic curves (AUROC).ResultsRSF revealed that five parameters, namely size of the tumor, BCLC-B sub-classification, AFP level, ALB level, and number of lesions, were strong predictors of survival. These were thereafter used for model development. The established model had a c-index of 0.69, whereas AUROC for predicting survival outcomes of the first three years reached 0.72, 0.71, and 0.73, respectively. Additionally, the model had better performance relative to other eight Cox proportional-hazards models, and excellent performance in the subgroup of BCLC-B sub-classification B I and B II stages.ConclusionThe RSF-based model, established herein, can effectively predict survival of patients with BCLC stage B HCC, with better performance than previous Cox proportional hazards models.