bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Potential Value of Texture Analysis Based on Dynamic Contrast-Enhanced MR Images in the Grading of Breast Phyllode Tumors
Authors: Li Xiaoguang , Guo Hong , Cong Chao , Liu Huan , Zhang Chunlai , Luo Xiangguo , Zhong Peng , Shi Hang , Fang Jingqin , Wang Yi 
Published: November 2021

PurposeTo explore the value of texture analysis (TA) based on dynamic contrast-enhanced MR (DCE-MR) images in the differential diagnosis of benign phyllode tumors (BPTs) and borderline/malignant phyllode tumors (BMPTs).MethodsA total of 47 patients with histologically proven phyllode tumors (PTs) from November 2012 to March 2020, including 26 benign BPTs and 21 BMPTs, were enrolled in this retrospective study. The whole-tumor texture features based on DCE-MR images were calculated, and conventional imaging findings were evaluated according to the Breast Imaging Reporting and Data System (BI-RADS). The differences in the texture features and imaging findings between BPTs and BMPTs were compared; the variates with statistical significance were entered into logistic regression analysis. The receiver operating characteristic (ROC) curve was used to assess the diagnostic performance of models from image-based analysis, TA, and the combination of these two approaches.ResultsRegarding texture features, three features of the histogram, two features of the gray-level co-occurrence matrix (GLCM), and three features of the run-length matrix (RLM) showed significant differences between the two groups (all p &lt; 0.05). Regarding imaging findings, however, only cystic wall morphology showed significant differences between the two groups (p = 0.014). The areas under the ROC curve (AUCs) of image-based analysis, TA, and the combination of these two approaches were 0.687 (95% CI, 0.518–0.825, p = 0.014), 0.886 (95% CI, 0.760–0.960, p &lt; 0.0001), and 0.894 (95% CI, 0.754–0.970, p &lt; 0.0001), respectively.ConclusionTA based on DCE-MR images has potential in differentiating BPTs and BMPTs.
A Multicenter Single-Arm Objective Performance Criteria Trial to Determine the Efficacy and Safety of High-Frequency Irreversible Electroporation as Primary Treatment for Localized Prostate Cancer: A Study Protocol
Authors: He Bi-Ming , Xue Wei , Yan Wei-Gang , Yin Lei , Dong Bai-Jun , Zhou Zhi-En , Lin Heng-Zhi , Zhou Yi , Wang Yan-Qing , Shi Zhen-Kai , Zhou Hai , Wang Shuai-Dong , Ren Shan-Cheng , Gao Xu , Wang Lin-hui , Xu Chuan-Liang , Wang Hai-Feng 
Published: November 2021

IntroductionThe classical pathway for the therapy of low- to intermediate-risk localized prostate cancer is radical prostatectomy or radiation therapy, which has shown a high incidence of complications, including erectile dysfunction, urinary incontinence, and bowel injury. An alternative pathway is to perform an ablation by some energy to the localized lesion, known as focal therapy. High-frequency irreversible electroporation (H-FIRE) is nonthermal energy that can be used in cancer ablation to deliver pulsed high-voltage but low-energy electric current to the cell membrane and to invoke cell death. An H-FIRE pathway has been reported to be tissue-selective, which leads to fewer side effects.Methods and AnalysisThis is a multicenter and single-arm objective performance criteria (OPC) study, in which all men with localized prostate cancer are allocated to H-FIRE ablation. This trial will assess the efficacy and safety of the H-FIRE ablation for prostate cancer. Efficacy will be assessed by prostate biopsy 6 months after treatment while safety will be assessed by adverse event reports and questionnaires. The main inclusion criteria are moderate to low-risk prostate cancer in NCCN risk classification and had no previous therapy for prostate cancer. A sample size of 110 participants is required. The primary objective is to determine whether the detection rate of clinically significant cancer by prostate biopsy is less than 20% after the H-FIRE ablation.Ethics and DisseminationThis study has obtained ethical approval by the ethics committee of all participating centers. The results of the study will be submitted for dissemination and publication in peer-reviewed journals.ConclusionsThis multicenter single-arm objective performance criteria trial will evaluate the efficacy and safety of the use of high-frequency irreversible electroporation in treating prostate cancer.Strengths and Limitations of This StudyA comprehensive evaluation of imaging and histopathology is used to determine the effect of treatment. Questionnaires were used to assess the treatment side effects. Multicenter and pragmatic designs capacitate higher generalizability. A limitation of this trial is that the prostate biopsy as an endpoint may not be as accurate as of the specimen from prostate prostatectomy. Another limitation is the 6-month follow-up time, making this trial challenging to come to firm conclusions regarding the efficacy and safety of IRE in the long term.Clinical Trial RegistrationClinicalTrials.gov, NCT03838432
Case Report: Unusual Clinical Presentation of a Rare Cardiac Inflammatory Myofibroblastic Tumor in Children: The Differential Diagnosis With Pediatric Emergencies
Authors: Bilotta Clio , Perrone Giulio , Maresi Emiliano , De Lisi Giovanni , Di Pasquale Pietro , Piro Ettore , Argo Antonina , Zerbo Stefania 
Published: November 2021

Introduction: There are still no guidelines about pediatric cardiac cancers. The purpose of this work is to provide new scientific data facilitating the differential diagnosis of a rare cardiac tumor with an unusual presentation, such as the cardiac inflammatory myofibroblastic tumor (IMT).Case Presentation: A 3-year-old male child presented with several symptoms including unconsciousness, vomiting, and drowsiness. A clinical and neurological examination revealed a unilateral (right) motor delay and positive unilateral Babinski sign. Electrocardiogram (ECG) was normal.Diagnostic Assessment: The total body computed tomography (CT) scans showed hypodensity in the left temporal–parietal lobe, a large hypodense area in the right frontal lobe, and a second area in the left frontal lobe were found with head CT. A magnetic resonance (MR) also noted cerebral areas of hypointensity. The echocardiographic images revealed an ovoid mass, adherent to the anterolateral papillary muscle. The histological exams, performed with hematoxylin–eosin, Masson's trichrome, Alcian blue PAS, Weigert and Van-Gieson stain, allowed observing the microscopic structure of the neoplastic mass. The immunohistochemical analysis was performed through subsequent antibodies: anti-vimentin, anti-actina, anti-ALK, anti-CD8, anti-CD3, anti-CD20, anti-kappa and lambda chains, and anti CD68 antibodies. The healthcare professionals diagnosed a cardiac IMT with brain embolism.Differential Diagnosis: The ventricular localization, observed through radiological exams, required a differential diagnosis with fibroma and rhabdomyoma, the presence of brain embolism with sarcoma, and its morphology with fibroma. Neurological symptoms might be attributed to encephalitis, primitive cerebral cancer, such as astrocytoma or neuroblastoma, cerebral metastases due to any malignancy, or embolic stroke.Conclusion: New studies are encouraged to better define IMT behavior and draw up guidelines confirming the crucial role of multidisciplinary approach and treatment protocol selected on the basis of the characteristics of the tumors, in the case of this rare type of cancer.
Childhood Hypercalciuric Hypercalcemia With Elevated Vitamin D and Suppressed Parathyroid Hormone: Long-Term Follow Up
Authors: Gurevich Evgenia , Levi Shelly , Borovitz Yael , Alfandary Hadas , Ganon Liat , Dinour Dganit , Davidovits Miriam 
Published: November 2021

Purpose: Hypercalcemia with low parathyroid hormone (PTH) level, hypercalciuria, nephrocalcinosis, or nephrolithiasis, was recently reported as caused by mutations in CYP24A1 and SLC34A genes. These encode for vitamin D-24A-hydroxylase and for the renal phosphate transporters NaPiIIa and NaPiIIc, respectively. We aimed to describe the clinical course of these monogenic disorders in patients with and without found mutations during long-term follow-up.Methods: Ten patients with hypercalcemia, hypercalciuria, elevated 1,25-(OH)2D levels and suppressed PTH were followed in our center during 1998–2019. Relevant laboratory and imaging data and results of genetic evaluation were retrieved from medical files.Results: The median age at presentation was 9.5 months (range 1 month−11 years), six were males, and the median follow-up time was 3.8 (1.1–14) years. Mutations in CYP24A1 and SLC34A3 were identified in three and one patients, respectively. Five patients presented with nephrocalcinosis, three with nephrolithiasis, and two had normal renal ultrasound. High blood calcium and 1,25-(OH)2D levels at presentation decreased during follow-up [11.1 ± 1 vs. 9.9 ± 0.5 mg/dl (p = 0.012), and 307 ± 130 vs. 209 ± 65 pmol/l (p = 0.03), respectively]; this paralleled an increase in suppressed PTH levels (5.8 ± 0.9 vs. 11.8 ± 7.3 pg/ml, p = 0.2). Substantial improvements in hypercalciuria and renal sonography findings were not observed. Two patients had impaired renal function (eGFR 84–88 ml/min/1/73 m2) at the last follow up. Interventions included appropriate diet, citrate supplementation, and thiazides.Conclusion: Despite improvement in hypercalcemia and 1,25-(OH)2D levels, not all the patients showed improvements in hypercalciuria and nephrocalcinosis. Deterioration of renal function was also observed. Long-term follow up and intervention to prevent nephrocalcinosis and nephrolithiasis are recommended in these children.
Psychological Distress Model Among Iranian Pre-Hospital Personnel in Disasters: A Grounded Theory Study
Authors: Azizi Maryam , Ebadi Abbas , Ostadtaghizadeh Abbas , Dehghani Tafti Abbasali , Roudini Juliet , Barati Mohammad , Khankeh Hamid Reza , Bidaki Reza 
Published: November 2021

Objective: Pre-hospital personnels (PHPs) who work in disasters under extreme pressure, uncertainty, and complex situations are victims of disasters themselves, and there is a link between experiencing such incidents and mental health problems. Because most studies focus on the injured and less on the psychological issues of PHPs, the present study aimed to develop a model to provide relief for PHPs in disasters from a psychological perspective.Methods: A grounded theory methodology recommended by Corbin and Strauss (2015) was employed. PHPs (n = 24) participated in a semi-structured interview between July 2018 to May 2020.Results: In the analysis of the pre-hospital staff interviews, three main themes were extracted, namely, providing relief with struggle (complexity of incident scenes, command-organizational and occupational challenges), psychological distress (psychological regression and psychological empowerment), and consequences (resilience and job burnout). Seven categories and 22 subcategories were explored from our data via the grounded theory approachConclusions: The PHPs managed psychological distress with two approaches: psychological self-empowerment and regression, which resulted in resilience and burnout, respectively. Due to the lack of enough support, the resilience of the PHPs was short-term, turned into burnout over time, and affected the structural factors again as a cycle.
Attachment and Therapeutic Alliance in Substance Use Disorders: Initial Findings for Treatment in the Therapeutic Community
Authors: Rübig Leonie L. , Fuchshuber Jürgen , Köldorfer Pia , Rinner Anita , Fink Andreas , Unterrainer Human-Friedrich 
Published: November 2021

Background: There is convincing evidence that individuals suffering from Substance Use Disorder (SUD) often present insecure attachment patterns. In contrast, a strong therapeutic alliance in treatment of SUD has been found to lead to a more positive treatment outcome. However, insecure attachment has been observed to be linked with weaker therapeutic alliance strength. The primary aim of this explorative study was to gain initial insights regarding the influence of attachment and personality characteristics on therapeutic alliance and therapy motivation in SUD patients undergoing treatment at a therapeutic community. Furthermore, SUD patients were compared to healthy controls regarding attachment, personality and mood pathology.Methods: A total sample of 68 participants, 34 inpatients in SUD treatment and 34 age-gender and education adjusted controls, were investigated. Both groups filled in the Adult Attachment Scale (AAS), the Inventory of Personality Organization (IPO-16), and the Brief Symptom Inventory (BSI-18) questionnaires. Additionally, SUD patients filled in the Working Alliance Inventory (WAI-SR) and the adapted German version of the University of Rhode Island Change Assessment scale (FEVER).Results: In line with our assumptions, SUD patients exhibited a decreased amount of attachment security (AAS) which was related to higher personality (IPO-16) and mood pathology (BSI-18). Furthermore, correlational analysis revealed the WAI-SR dimension Bond being positively associated with more secure attachment. A strong task alliance was linked to the Action stage of change (FEVER) and decreased mood but not personality pathology.Conclusion: Our findings confirm the putative negative effect of attachment and personality pathology on therapy motivation and therapeutic alliance in addiction therapy as well as more specifically in therapeutic community treatment. Future research in enhanced samples might focus more on the long-term effects of the interaction of attachment, personality and therapeutic alliance variables.
Programa de Educación Universitaria para jóvenes que presten servicio militar en zonas de frontera - Perú UniFFAAGoL
Authors: Bocanegra García Carlos A. , Camacho Delgado Freddy M. 
Published: November 2021

Se presenta un Programa de educación universitaria inclusiva para jóvenes que presten servicio militar en zonas de frontera, al cual se le puede denominar UniFFAAGoL, sustentado en los actores: Universidad, Fuerzas Armadas (FFAA), y Gobiernos Locales. El objetivo fue contribuir al desarrollo local utilizando sus fortalezas. El programa es una respuesta a la falta de oportunidades educativas a nivel superior en las zonas de frontera, al escaso desarrollo de las comunidades, y poco interés por el servicio militar voluntario, la creciente desocupación y con ello la delincuencia. La propuesta surge ante la pregunta como enfrentamos creativamente o desarrollamos la “imaginación” para superar esta situación. La investigación se desarrolló empleando el método etnográfico. Los resultados demuestran la factibilidad del programa y puede ser un referente bajo las condiciones descritas.
Procrastinación de valores éticos y su impacto en la corrupción sector educación Junín Perú 2020
Authors: Chamorro Mejía Rafael , Chamorro Llantoy Sara Pilar 
Published: November 2021

Actualmente la sociedad afronta una crisis social globalizante. Ante los nuevos desafíos de la sociedad en conseguir el bienestar social, se tiene la imperiosa necesidad de contribuir en el control de problemas sociales. En el estudio se planteó como objetivo, describir y explicar el impacto de la procrastinación del código de valores éticos en la globalización de la corrupción sector educación región Junín Perú. Los métodos y diseños empleados fueron: Investigación cualitativa, método científico inductivo-deductivo con el diseño fenomenológico, estrategia hermenéutica, segmentación e integración para procesar los resultados. Se entrevistó a diez informantes claves trabajadores idóneos y calificados de las diez UGELs región Junín; obteniendo los resultados: la procrastinación de valores éticos se articulan con implicancia en el crecimiento de los actos delictivos en sus diferentes formas de corrupción. Se concluyó que la procrasstinación de valores éticos, impacta fuertemente en globalización de la corrupción sector educación región Junín Perú.
Factores socioeconómicos y engagement académico en estudiantes universitarios en contextos de pandemia por SARS-CoV-2
Authors: Valero Ancco Vidnay Noel , Calderon Quino Katty Maribel , Pari Orihuela Miryam , Arpasi Mamani Uriel 
Published: November 2021

La presente investigación se guio por el objetivo de establecer si los factores socio- económicos como el acceso a la tecnología, servicio de internet y la condición laboral se relacionan con el engagement académico (EA) en estudiantes universitarios en contextos de educación remota. El trabajo se enmarca en el tipo no experimental con diseño correlacional transversal y explicativo. La muestra fue conformada por 253 estudiantes de la Facultad de Ciencias de la Educación, específicamente 222 damas y 31 varones, seleccionados por un criterio no probabilístico. Para recoger la información se empleó la técnica de la encuesta a través del cuestionario sociodemográfico y el cuestionario de Utrecht Work Engagement Scale (UWES-17) administrado vía Google Forms. Los resultados encontrados indican que no existe relación entre el acceso a la tecnología, servicio de internet y la condición laboral con el EA en universitarios en contextos de educación remota.
UPAYA HUKUM KREDITOR SEBAGAI PENANGKAL RISIKO HAPUSNYA HAK ATAS TANAH YANG DIAGUNKAN
Authors: Anand Ghansam 
Published: November 2021

ABSTRACT The creditor certainly wants a position that is not the same as other creditors, because the same position with other creditors means getting equal rights with other creditors of the proceeds from the sale of the debtor's property, if the debtor is liable to the promise. The balanced position does not provide certainty of guaranteed return of receivables. The more creditors of the debtor are concerned, the less likely it is to guarantee the return of the receivable if for some reason the debtor becomes insolvent (unable to pay its debts). The procurement of legally guaranteed copyrights is to provide a position for a particular creditor to take precedence over other creditors. It is also the objective of the existence of Mortgage Rights as regulated by Law Number 4 Year 1996 concerning the Right of Million of Land and Land Related. One of the events that eliminated the Mortgage right is mentioned in Article 18 paragraph (1d) UUHT, that as the last mentioned basis for the abolition of Mortgage right is the abolition of land rights. The abolition of land rights takes place over time, for which the right is granted. Rights that are lower in rank than property rights such as the right to use, the right to use and the right to use are limited in time, even if physically still exist. With the termination of the rights to the land concerned, the rights to the land concerned shall return to the concerned owner or owner and if such right is granted by the state, then the land is returned to the state power. Thus, the creditor of the dependent will lose his position as the preferred creditor. Keywords: Creditors, Debtors, Deposit Rights
Pemerintahan Pada Masa Transisi Pergantian Kepala DaerahDalam Perspektif Otonomi Daerah
Authors: Hasan Abdul Azis 
Published: November 2021

Abstract Two problem formulations were discussed in this study, namely the politics of law of governance in the transition period of the replacement of regional heads in Indonesia and the organizational design and governance work in the transition period of the replacement of regional heads in the perspective of regional autonomy. As a normative legal research, it used the statute and the conceptual approaches. Based on the results of the study it was concluded that the politics of law of regional governance in the transition period of the replacement of regional heads in Indonesia are partially regulated in Law Number 10 of 2016 where regional heads are prohibited from replacing officials 6 (six) months prior to the date of the nomination of candidate pairs up to the end of the term of office and 6 (six) months from the date of inauguration unless obtaining written approval from the Minister. Furthermore, in Regulation of the Minister of Home Affairs No. 86 of 2017, it is regulated that the formulation of vision, mission and program of candidates for regional head and deputy regional head must be guided by the RPJPD and if there is a time lag between the elections until the inauguration of the elected regional head exceeds a period of 6 (six) months, the draft the RPJMD technocracy can be refined by referring to the vision, mission, and program of the elected regional head. The implementation of the two regulations has the potential to violate the principles of regional government implementation, namely professionalism, public Intertest, and effectiveness. In order to minimize the potential violations of the principle of regional government implementation, it is necessary to revise Law Number 10 of2016 and Permendagri Number 86 of 2017. Keywords: Regional Government, Transition Period Substitution of RegionalHeads, Transition
Analysis of the state of preservation the historic arcaded houses in Vistula Delta listed in the National Inventory of Historical Monuments
Authors: Zybala Tomasz 
Published: November 2021

Historic arcaded houses are part of the material heritage of the Vistula Delta. Unfortunately, their number is decreasing year by year. The article is the result of a query of available sources and field research carried out by the author in 2015-2020. The paper presents the current state of preservation the historic arcaded houses in Vistula Delta listed in the National Inventory of Historical Monuments. Criteria for the selection of test objects are described. The author has prepared a tabular list of arcaded houses with information about their location, type according to Kloeppel statistics, date of construction, technical condition and functions. The summary of the analysis are pie charts with a statistical presentation of the data collected by the author during the research.
Protocolo de Gerenciamento de Risco Incisional em Cirurgia Cardí­aca: série de casos com cobertura oclusiva de Tecnologia Hydrofiber® com prata iônica.
Authors: Campana Ricardo , Lopes Sottomaior Pereira Marta , Rissato Piekarski Aline Cristina , Paladini Cavazana Carla , Datrino de Paula Mariana , Miranda Jéssica Steffany 
Published: November 2021

A mediastinite é um dos tipos de infecção de sí­tio cirúrgico (ISC) em cirurgia cardiovascular, sendo uma complicação infecciosa grave e frequentemente desastrosa. O objetivo do estudo é descrever um protocolo de gerenciamento de risco local em incisão cirúrgica através da avaliação de uma série de casos de pacientes que foram submetidos í cirurgia cardí­aca por esternotomia longitudinal. Método: série de casos com análise quantitativa e retrospectiva realizada por meio de consulta aos prontuários eletrônicos de pacientes que foram submetidos í cirurgia cardí­aca com esternotomia longitudinal que utilizaram cobertura impermeável de Tecnologia Hydrofiber® com prata iônica. Resultados: Foram analisados 75 prontuários e incluí­dos no estudo 69 pacientes, no perí­odo de 01 de janeiro de 2020 a 31 de março de 2020. Destes, a maioria eram do sexo masculino (48), com faixas etárias entre 51 a 64 anos e acima de 65 anos, tiveram o procedimento com duração média de 4 horas ou mais (95,60%) e permaneceram, em média, 10 dias internados. Conclusão: nenhum paciente apresentou sinais de ISC ao utilizar a cobertura AQUACEL® Ag SURGICAL (ConvaTec, Reino Unido), e esse resultado foi garantido a partir da implementação de um Protocolo de Gerenciamento de Risco Incisional.