bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPLEMENTASI PENDIDIKAN AGAMA ISLAM DI SMP ISLAM TERPADU DI KALANGAN NU
Authors: Zakiyah Zakiyah 
Published: August 2021

Artikel ini membahas tema pelaksanaan Pendidikan Agama Islam (PAI) di Sekolah Menengah Pertama Islam Terpadu (SMP IT) Syakur Al Marzuki yang berada di desa Nglingi Bareng Kecamatan Ngasem, Kabupaten Bojonegoro, Jawa Timur. Topik ini penting dikaji karena PAI merupakan mata pelajaran wajib yang harus diberikan kepada peserta didik dan pada saat yang sama dalam beberapa tahun terakhir perkembangan sekolah-sekolah dengan label Islam Terpadu (IT) semakin berkembang dan bermunculan, tidak saja sekolah yang masuk ke dalam jaringan Sekolah Islam Terpadu (SIT), namun juga sekolah yang berafiliasi dengan organisasi Islam seperti Muhammadiyah dan Nahdlatul Ulama (NU) membuka sekolah dengan model ini, salah satunya adalah SMP IT Syakur Al Marzuki yang berafilisasi dengan NU. Artikel ini ditulis berdasarkan hasil penelitian yang dilaksanakan pada tahun 2018. Adapun data dikumpulkan dengan beberapa metode meliputi wawancara, observasi dan studi pustaka. Hasil penelitian ini memperlihatkan bahwa SMP IT Syakur Al Marzuki melaksanakan PAI pada proses pembelajaran di dalam kelas dan melalui pembiasaan ibadah, serta perilaku. Meskipun berlabel IT, sekolah ini menyasar anak-anak dari keluarga menengah ke bawah di wilayah sekitar sekolah ini untuk dapat melanjutkan belajar dengan biaya murah dan gratis, serta mendapatkan pendidikan agama Islam secara komprehensif. Sekolah ini juga mempunyai program unggulan “tahfiz” dan menyediakan pesantren untuk siswa-siswinya.
AN INTERVENTIONAL STUDY OF LOW DOSE HUMAN MENOPAUSAL GONADOTROPIN WITH CLOMIPHENE CITRATE FOR OVULATION INDUCTION IN CLOMIPHENE RESISTANT POLYCYSTIC OVARIAN SYNDROME WOMEN IN THE DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY, SMS MEDICAL COLLEGE, JAIPUR
Authors: Gupta Deepshikha , Joshi Narendra , Mendiratta Suman 
Published: August 2021

Background:
Methods: The present study is a single arm interventional study done at a tertiary care hospital in a metropolitan city. The study participants were the females who had infertility due to PCOS and resistant to clomiphene citrate, and participants were given HMG in a sequential manner with Clomiphene citrate and ovulation was observed using the TVS.
Results: 79% of the study participants ovulated at the end of the study as a final outcome and only 25 participants who constitute 21% of the total had not ovulated. No cases of ovarian hyperstimulation and multiple gestation was reported.
Conclusion: The study thus concludes that CC with low dose HMG is an efficient and safe method for induction of ovulation in females with CC resistant PCOS related infertility without the dangers of OHSS and other adverse events, also the presence of normal BMI can help in a better rate of ovulation
Keywords: HMG, TVS, Infertility
Evolution of Freight Villages and Dry Ports from the Macro Logistics Perspective Based on European Benchmarking 2020
Authors: Oláh Judit , Nestler Steffen , Nobel Thomas , Popp József 
Published: August 2021

Being the initiator of the German and European Freight Village ranking, Deutsche GVZ-Gesellschaft (DGG) has the methodical know how to create the benchmarking studies. In this ranking approximately 100 Freight Village locations were analysed and evaluated. The research was based on the generation of an uniform understanding, which was focused on intermodality and the significant distinctive management structures. This data led to a qualitative and detailed overview. Because of the positive response, we were motivated to start the second ranking in 2015, as well as the update in 2019/2020. The results of the ranking show important basics and facts, which demonstrate the importance of the Freight Villages and strengthened their role as central, intermodal logistics nodes. Moreover, the responsible decision makers in the Freight Villages benefit from the results of the benchmarking. Many management companies use their placement in the ranking for public relations activities. Good placements or improvements are important instruments in marketing strategies.
A Facile Fabrication of ZnFe2O4/Sepiolite Composite with Excellent Photocatalytic Performance on the Removal of Tetracycline Hydrochloride
Authors: Zhang Caihong , Han Xiaoyu , Wang Fei , Wang Lijuan , Liang Jinsheng 
Published: August 2021

The excellent photo-response of ZnFe2O4 in the visible light region makes it a promising catalyst, whereas some defects like serious particle agglomeration and easy recombination of photo-generated electron-hole pairs hinder its application. In this work, the ZnFe2O4/sepiolite (ZF-Sep) composites were synthesized using a co-precipitation method. The obtained ZF-Sep composites were characterized by XRD, SEM, TEM, FT-IR, XPS, BET, VSM and DRS. Moreover, the photocatalytic performance was evaluated by the tetracycline hydrochloride removal efficiency under simulated visible light illumination. The results displayed that the ZnFe2O4 with average sizes about 20 nm were highly dispersed on sepiolite nanofibers. All the composites exhibited better photocatalytic performance than pure ZnFe2O4 due to the synergistic effect of the improvement on the agglomeration phenomenon of ZnFe2O4 and the reduction on the recombination rate of photo-generated electrons and holes. The optimum removal efficiency was that of the ZF-Sep-11 composite, which reached 93.6% within 3 h. Besides, the composite exhibited an excellent stability and reusability. Therefore, ZF-Sep composite is a promising catalyst for the treatment of wastewater contained antibiotics.
Evaluation of Magnetic Stirring and Aeration on Electrocoagulation Performance in Actual Industrial Treatment
Authors: Trinh Dang Trung Tri , Binh Quach An , Ty Tran Van , Channei Duangdao , Nakaruk Auppatham , Khanitchaidecha Wilawan 
Published: August 2021

Agitation was a significant factor in achieving the high performance of the electrocoagulation (EC) system. Three EC systems with four parellal monopolar Al electrodes were established to clarify the influence of agitation methods on pollutants removal efficiency; magnetic stirring, continuous aeration, and combination of magnetic stirring and aeration. The aim of this work was to maximize industrial wastewater treatment in a short detention time and to understand the mechanisms that occurred in different EC systems. The coolant wastewater from the aluminum product industry was represented as industrial wastewater. The hybrid stirring-aeration EC system obtained a lower COD removal compared to the stirring EC system and the aeration EC system. Although aeration can cause an increase in COD removal due to complete circulation and effective coagulant formation of Fe (OH), however, the combination of aeration and stirring negatively affected the performance of CE. The possible reason was that the excessive agitation led to a rapid mixing of the solution, and then the coagulants and pollutants obtained insufficient time to form flocs to precipitate. The best EC performance was observed in the aeration EC system, followed by the stirring EC system, control system (without agitations), and the stirring aeration EC system, respectively, in the short detention time of 15 min. Furthermore, all EC systems could achieve an excellent COD removal of 91% when the detention time was sufficient (eg, 45 min for the stirring aeration EC system). Furthermore, the decreasing number of electrodes affected the COD removal efficiency, whereas the NaCl additive was insignificantly affected.
Genetic Polymorphism of Vitamin D Family Genes CYP2R1, CYP24A1, and CYP27B1 Are Associated With a High Risk of Non-alcoholic Fatty Liver Disease: A Case-Control Study
Authors: Wang Minxian , Zhang Ru , Wang Min , Zhang Liuxin , Ding Yajie , Tang Zongzhe , Wang Hongliang , Zhang Wei , Chen Yue , Wang Jie 
Published: August 2021

BackgroundPrevious studies have highlighted the important role of vitamin D and calcium pathway genes in immune modulation, cell differentiation and proliferation, and inflammation regulation, all closely implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD).ObjectiveThis study aims to investigate whether 11 candidate single nucleotide polymorphisms (SNPs) in vitamin D and calcium pathway genes (CYP2R1, CYP24A1, and CYP27B1) are associated with the risk of NAFLD.MethodsIn this case-control study, a total of 3,023 subjects were enrolled, including 1,114 NAFLD cases and 1,909 controls. Eleven genetic variants in CYP2R1, CYP24A1, and CYP27B1 genes were genotyped. Logistic regression analysis was used to assess the effects of these variants on NAFLD risk. The functional annotations of positive SNPs were further evaluated by bioinformatics analysis.ResultsAfter adjusting for age, gender, and metabolic measures, we identified that CYP24A1 rs2296241 variant genotypes (recessive model: OR, 1.316; 95% CI, 1.048–1.653; p = 0.018), rs2248359 variant genotypes (recessive model: OR, 1.315; 95% CI, 1.033–1.674; p = 0.026), and CYP27B1 rs4646536 variant genotypes (additive model: OR, 1.147; 95% CI, 1.005–1.310; p = 0.042) were associated with an elevated risk of NAFLD. In combined effects analysis, we found that NAFLD risk significantly increased among patients carrying more rs2296241-A, rs2248359-T, and rs4646536-T alleles (ptrend = 0.049). Multivariate stepwise analysis indicated that age, visceral obesity, ALT, γ-GT, hypertriglyceridemia, hypertension, low HDL-C, hyperglycemia, and unfavorable alleles were independent predictors of NAFLD (all p &lt; 0.05). The area under the receiver operating characteristic curve was 0.789 for all the above factors.ConclusionThe polymorphisms of vitamin family genes CYP24A1 (rs2296241, CYP24A1, and rs2248359) and CYP27B1 (rs4646536) were associated with NAFLD risk in Chinese Han population, which might provide new insight into NAFLD pathogenesis and tools for screening high-risk population.
ICAM-1 and ICAM-2 Are Differentially Expressed and Up-Regulated on Inflamed Pulmonary Epithelium, but Neither ICAM-2 nor LFA-1: ICAM-1 Are Required for Neutrophil Migration Into the Airways In Vivo
Authors: Chong Deborah L. W. , Rebeyrol Carine , José Ricardo J. , Williams Andrew E. , Brown Jeremy S. , Scotton Chris J. , Porter Joanna C. 
Published: August 2021

Neutrophil migration into the airways is an important process to fight infection and is mediated by cell adhesion molecules. The intercellular adhesion molecules, ICAM-1 (CD54) and ICAM-2 (CD102) are known ligands for the neutrophil integrins, lymphocyte function associated antigen (LFA)-1 (αLβ2; CD11a/CD18), and macrophage-1 antigen (Mac-1;αMβ2;CD11b/CD18) and are implicated in leukocyte migration into the lung. However, it is ill-defined how neutrophils exit the lung and the role for ICAMs in trans-epithelial migration (TEpM) across the bronchial or alveolar epithelium. We found that human and murine alveolar epithelium expressed ICAM-1, whilst the bronchial epithelium expressed ICAM-2, and both were up-regulated during inflammatory stimulationin vitro and in inflammatory lung diseases such as cystic fibrosis. Although β2integrins interacting with ICAM-1 and -2 mediated neutrophil migration across human bronchial epitheliumin vitro, neither ICAM-2 nor LFA-1 binding of ICAM-1 mediated murine neutrophil migration into the lung or broncho-alveolar space during LPS-induced inflammationin vivo. Furthermore, TEpM of neutrophils themselves resulted in increased epithelial junctional permeability and reduced barrier functionin vitro. This suggests that although β2integrins interacting with ICAMs may regulate low levels of neutrophil traffic in healthy lung or early in inflammation when the epithelial barrier is intact; these interactions may be redundant later in inflammation when epithelial junctions are disrupted and no longer limit TEpM.
Shrimp Plasma CREG Is a Hemocyte Activation Factor
Authors: Huang Zhiqi , Yang Peng , Wang Fan 
Published: August 2021

Cytokines are a class of immunoregulatory proteins that are secreted by cells. Although vertebrate cytokine, especially mammalian cytokine has been well studied for the past decades. Much less attention has been paid to invertebrate so that only some cytokines have been identified in invertebrates. We have chosen Peaneus vannamei as a model to explore novel invertebrate cytokines. To achieve this, we previously purified shrimp plasma low abundance proteins and identified more than 400 proteins with proteomics analyses. In this study, a cellular repressor of E1A-stimulated gene (CREG)-like protein, which is highly conserved from Drosophila melanogaster to Homo sapiens, was further characterized in shrimp plasma. We found that shrimp plasma CREG was a glycoprotein which was strongly induced in hemolymph at 8 h post-LPS injection. Further function experiment unveiled that recombinant shrimp CREG protein injection significantly increased phagocytic hemocyte and lysosome-high hemocyte proportion in hemolymph. After that, hemocytes from rEGFP- and rCREG-protein injected shrimps were subjected to transcriptome analyses, which revealed that shrimp CREG protein could comprehensively promote hemocyte maturation and activation. Taken together, our data clearly indicated that shrimp plasma CREG protein is a novel hemocyte activation factor, which is probably a conserved myeloid cell lineage activation factor from invertebrate to vertebrate.
Corticosteroids for Treating Sepsis in Adult Patients: A Systematic Review and Meta-Analysis
Authors: Liang Huoyan , Song Heng , Zhai Ruiqing , Song Gaofei , Li Hongyi , Ding Xianfei , Kan Quancheng , Sun Tongwen 
Published: August 2021

ObjectiveCorticosteroids are a common option used in sepsis treatment. However, the efficacy and potential risk of corticosteroids in septic patients have not been well assessed. This review was performed to assess the efficacy and safety of corticosteroids in patients with sepsis.MethodsPubMed, Embase, and Cochrane library databases were searched from inception to March 2021. Randomized controlled trials (RCTs) that evaluated the effect of corticosteroids on patients with sepsis were included. The quality of outcomes in the included articles was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation methodology. The data were pooled by using risk ratio (RR) and mean difference (MD). The random-effects model was used to evaluate the pooled MD or RR and 95% confidence intervals (CIs).ResultsFifty RCTs that included 12,304 patients with sepsis were identified. Corticosteroids were not associated with the mortality in 28-day (RR, 0.94; 95% CI, 0.87–1.02; evidence rank, moderate) and long-term mortality (&gt;60 days) (RR, 0.96; 95% CI, 0.88–1.05) in patients with sepsis (evidence rank, low). However, corticosteroids may exert a significant effect on the mortality in the intensive care unit (ICU) (RR, 0.9; 95% CI, 0.83–0.97), in-hospital (RR, 0.9; 95% CI, 0.82–0.99; evidence rank, moderate) in patients with sepsis or septic shock (evidence rank, low). Furthermore, corticosteroids probably achieved a tiny reduction in the length of hospital stay and ICU. Corticosteroids were associated with a higher risk of hypernatremia and hyperglycemia; furthermore, they appear to have no significant effect on superinfection and gastroduodenal bleeding.ConclusionsCorticosteroids had no significant effect on the 28-day and long-term mortality; however, they decreased the ICU and hospital mortality. The findings suggest that the clinical corticosteroids may be an effective therapy for patients with sepsis during the short time.Systematic Review Registrationhttps://inplasy.com/wp-content/uploads/2021/05/INPLASY-Protocol-1074-4.pdf
Evaluating the Flame Retardancy of Shaving Super Bamboo Layer by Layer Self-Assembly With Phytic Acid-Polyethyleneimine
Authors: Lin Peng , Jiang Yingqiu , Ru Xiaolin , Che Wenbo , Zhang Xiaochun , Ma Lingfei , Hou Junfeng , Yu Youming 
Published: August 2021

To improve the flame retardancy of bamboo materials, layer by layer (LbL) self-assembly of phytic acid (PA)-polyethyleneimine (PEI) on the surface of shaving super bamboo specimens with different solution concentrations of PA-PEI and times of LbL self-assembly was completed in this study. Fourier transform infrared analysis results showed that PEI was well assembled to the surface of bamboo specimens by a hydrogen bond with PA as intermediation. The application of PA and PEI significantly promoted the formation of carbon residue, as characterized by simultaneous thermal measurements. Particularly, the peak heat release rate and total heat release rate of bamboo self-assembly with 10 wt% PA and 10 wt% of PEI solution were reduced by 19.36 and 22.3%, respectively. The treated bamboo specimen showed increases of 35.56 and 480.70% in fire performance index and residual mass, respectively, compared to the control sample. Besides, yields of CO and CO2 were decreased by 17.77 and 17.07% in comparison with the control group, respectively. The LbL self-assembly with PA-PEI can effectively improve the flame retardancy of bamboo materials by promoting the formation of a residual char layer.
A First Clinical Trial on Botulinum Toxin-A for Chronic Muscle-Related Pain in Cerebral Palsy
Authors: Jacobson Dan , Löwing Kristina , Kullander Kjell , Rydh Britt-Marie , Tedroff Kristina 
Published: August 2021

Objective: To test if botulinum toxin-A (BoNT-A) is effective in reducing chronic muscle-related pain in adults with spastic cerebral palsy (CP), as compared to placebo.Design: A single-center, double-blind, parallel, randomized placebo-controlled trial. The design included an interim analysis to allow for confirmatory analysis, as well as pilot study outcomes.Setting: Tertiary university hospital.Participants: Adults with spastic CP and chronic pain associated with spastic muscle(s).Intervention: Treatment was one session of electromyographically guided intramuscular injections of either BoNT-A or placebo normosaline.Main Study Outcomes: The primary outcome was the proportion who achieved a reduction of pain intensity of two or more steps on the Numerical Rating Scale 6 weeks after treatment.Results: Fifty individuals were screened for eligibility, of whom 16 were included (10 female, 6 male, mean age = 32 years, SD = 13.3 years). The randomization yielded eight participants per treatment arm, and all completed the study as randomized. The study was stopped at the interim analysis due to a low probability, under a preset threshold, of a positive primary outcome. Four individuals were treatment responders in the BoNT-A group for the primary outcome compared to five responders in the placebo group (p = 1.000). Adverse events were mild to moderate. In exploratory analysis, the BoNT-A group had a trend of continuing reduction of pain at the last follow-up, after the primary endpoint.Conclusions: This study did not find evidence that BoNT-A was superior to placebo at the desired effect size (number needed to treat of 2.5) at 6 weeks after treatment.Trial registration:ClinicalTrials.gov: NCT02434549
Revealing Sex Differences During Upper and Lower Extremity Neuromuscular Fatigue in Older Adults Through a Neuroergonomics Approach
Authors: Mehta Ranjana K. , Rhee Joohyun 
Published: August 2021

Background: Sex differences in neuromuscular fatigue is well-documented, however the underlying mechanisms remain understudied, particularly for the aging population.Objective: This study investigated sex differences in fatigability of the upper and lower extremity of older adults using a neuroergonomics approach.Methods: Thirty community-dwelling older adults (65 years or older; 15 M, 15 F) performed intermittent submaximal fatiguing handgrip and knee extension exercises until voluntary exhaustion on separate days. Muscle activity from prime muscles of the hand/arm and knee extensors were monitored using electromyography, neural activity from the frontal, motor, and sensory areas were monitored using functional near infrared spectroscopy, and force output were obtained.Results: While older males were stronger than females across both muscle groups, they exhibited longer endurance times and greater strength loss during knee extension exercises. These lower extremity findings were associated with greater force complexity over time and concomitant increase in left motor and right sensory motor regions. While fatigability during handgrip exercises was comparable across sexes, older females exhibited concurrent increases in the activation of the ipsilateral motor regions over time.Discussion: We identified differences in the underlying central neural strategies adopted by males and females in maintaining downstream motor outputs during handgrip fatigue that were not evident with traditional ergonomics measures. Additionally, enhanced neural activation in males during knee exercises that accompanied longer time to exhaustion point to potential rehabilitation/exercise strategies to improve neuromotor outcomes in more fatigable older adults.
Radiomic Score as a Potential Imaging Biomarker for Predicting Survival in Patients With Cervical Cancer
Authors: Li Handong , Zhu Miaochen , Jian Lian , Bi Feng , Zhang Xiaoye , Fang Chao , Wang Ying , Wang Jing , Wu Nayiyuan , Yu Xiaoping 
Published: August 2021

ObjectivesAccurate prediction of prognosis will help adjust or optimize the treatment of cervical cancer and benefit the patients. We aimed to investigate the incremental value of radiomics when added to the FIGO stage in predicting overall survival (OS) in patients with cervical cancer.MethodsThis retrospective study included 106 patients with cervical cancer (FIGO stage IB1–IVa) between October 2017 and May 2019. Patients were randomly divided into a training cohort (n = 74) and validation cohort (n = 32). All patients underwent contrast-enhanced computed tomography (CT) prior to treatment. The ITK-SNAP software was used to delineate the region of interest on pre-treatment standard-of-care CT scans. We extracted 792 two-dimensional radiomic features by the Analysis Kit (AK) software. Pearson correlation coefficient analysis and Relief were used to detect the most discriminatory features. The radiomic signature (i.e., Radscore) was constructed via Adaboost with Leave-one-out cross-validation. Prognostic models were built by Cox regression model using Akaike information criterion (AIC) as the stopping rule. A nomogram was established to individually predict the OS of patients. Patients were then stratified into high- and low-risk groups according to the Youden index. Kaplan–Meier curves were used to compare the survival difference between the high- and low-risk groups.ResultsSix textural features were identified, including one gray-level co-occurrence matrix feature and five gray-level run-length matrix features. Only the FIGO stage and Radscore were independent risk factors associated with OS (p &lt; 0.05). The C-index of the FIGO stage in the training and validation cohorts was 0.703 (95% CI: 0.572–0.834) and 0.700 (95% CI: 0.526–0.874), respectively. Correspondingly, the C-index of Radscore was 0.794 (95% CI: 0.707–0.880) and 0.754 (95% CI: 0.623–0.885). The incorporation of the FIGO stage and Radscore achieved better performance, with a C-index of 0.830 (95% CI: 0.738–0.922) and 0.772 (95% CI: 0.615–0.929), respectively. The nomogram based on the FIGO stage and Radscore could individually predict the OS probability with good discrimination and calibration. The high-risk patients had shorter OS compared with the low-risk patients (p &lt; 0.05).ConclusionRadiomics has the potential for noninvasive risk stratification and may improve the prediction of OS in patients with cervical cancer when added to the FIGO stage.