bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing consistency across functional screening datasets in cancer cells
Authors: Cai Ling , Liu Hongyu , Minna John D , DeBerardinis Ralph J , Xiao Guanghua , Xie Yang 
Published: June 2021

Abstract

Motivation
Many high-throughput screening studies have been carried out in cancer cell lines to identify therapeutic agents and targets. Existing consistency assessment studies only examined two datasets at a time, with conclusions based on a subset of carefully selected features rather than considering global consistency of all the data. However, poor concordance can still be observed for a large part of the data even when selected features are highly consistent.

Results
In this study, we assembled nine compound screening datasets and three functional genomics datasets. We derived direct measures of consistency as well as indirect measures of consistency based on association between functional data and copy number-adjusted gene expression data. These results have been integrated into a web application—the Functional Data Consistency Explorer (FDCE), to allow users to make queries and generate interactive visualizations so that functional data consistency can be assessed for individual features of interest.

Availability and implementation
The FDCE web tool and we have developed and the functional data consistency measures we have generated are available at https://lccl.shinyapps.io/FDCE/.

Supplementary information
Supplementary data are available at Bioinformatics online.
Transcriptomic analysis of human brains with Alzheimer’s disease reveals the altered expression of synaptic genes linked to cognitive deficits
Authors: Williams Jamal B , Cao Qing , Yan Zhen 
Published: June 2021

Abstract
Alzheimer’s disease is a progressive neurodegenerative disorder associated with memory loss and impaired executive function. The molecular underpinnings causing cognitive deficits in Alzheimer’s disease are loosely understood. Here, we performed cross-study large-scale transcriptomic analyses of postmortem prefrontal cortex derived from Alzheimer’s disease patients to reveal the role of aberrant gene expression in this disease. We identified that one of the most prominent changes in prefrontal cortex of Alzheimer’s disease humans was the downregulation of genes in excitatory and inhibitory neurons that are associated with synaptic functions, particularly the SNARE-binding complex, which is essential for vesicle docking and neurotransmitter release. Comparing genomic data of Alzheimer’s disease with proteomic data of cognitive trajectory, we found that many of the lost synaptic genes in Alzheimer’s disease encode hub proteins whose increased abundance is required for cognitive stability. This study has revealed potential molecular targets for therapeutic intervention of cognitive decline associated with Alzheimer’s disease.
Differential effect of ethanol intoxication on peripheral markers of cerebral injury in murine blunt traumatic brain injury
Authors: Li Zhenghui , Zhang Jin , Halbgebauer Steffen , Chandrasekar Akila , Rehman Rida , Ludolph Albert , Boeckers Tobias , Huber-Lang Markus , Otto Markus , Roselli Francesco , Heuvel Florian olde 
Published: June 2021

Abstract

Background
Blood-based biomarkers have proven to be a reliable measure of the severity and outcome of traumatic brain injury (TBI) in both murine models and patients. In particular, neuron-specific enolase (NSE), neurofilament light (NFL) and S100 beta (S100B) have been investigated in the clinical setting post-injury. Ethanol intoxication (EI) remains a significant comorbidity in TBI, with 30–40% of patients having a positive blood alcohol concentration post-TBI. The effect of ethanol on blood-based biomarkers for the prognosis and diagnosis of TBI remains unclear. In this study, we investigated the effect of EI on NSE, NFL and S100B and their correlation with blood–brain barrier integrity in a murine model of TBI.

Methods
We used ultra-sensitive single-molecule array technology and enzyme-linked immunosorbent assay methods to measure NFL, NSE, S100B and claudin-5 concentrations in plasma 3 hours post-TBI.

Results
We showed that NFL, NSE and S100B were increased at 3 hours post-TBI. Interestingly, ethanol blood concentrations showed an inverse correlation with NSE but not with NFL or S100B. Claudin-5 levels were increased post-injury but no difference was detected compared to ethanol pretreatment. The increase in claudin-5 post-TBI was correlated with NFL but not with NSE or S100B.

Conclusions
Ethanol induces an effect on biomarker release in the bloodstream that is different from TBI not influenced by alcohol. This could be the basis of investigations into humans.
Mapping and quantification of the twitter footprint of cardiologists
Authors: Kalra Ankur , Kumar Ashish , Nowacki Amy S , Shahadat Amna , Khan Muhammad Shahzeb , Jabri Ahmad , Khan Safi U , Michos Erin D , Califf Robert M , Bhatt Deepak L 
Published: June 2021

Abstract

Aims
The increasing importance placed by medical journals for dissemination of published articles on social media, such as posting Altmetric scores, has further expedited the need for differentiating bona fide science from pseudo-science. The ‘Kardashian index’ (a.k.a., K-index) was suggested, which correlates the citations of a scientist with his/her Twitter followers.

Methods and results
From a list of top 100 cardiology hospitals in accordance with the most recent US News and World Report rankings, 1500 cardiologists were selected based on institutional physician profile pages complete with cardiologists’ headshots. The K-index of cardiologists, and variables like all-time posts, and posts for the past 12 months (1 June 2019 to 31 May 2020) from cardiologists were documented and analysed. The K-index of cardiologists in our study was stratified into the following categories (upper boundary inclusive); K-index 0–1 (n = 104); K-index 1–2 (n = 30); K-index 2–3 (n = 24); K-index 3–4 (n = 14); K-index 4–5 (n = 5); and K-index &gt;5 (n = 22). There was no statistically significant difference (P = 0.94) in the citation number across the K-index categories (no consistent pattern observed, median citations ranging from 237 to 610). However, cardiologists with higher K-index categories had a higher number of 12-month posts (median 14 vs. 392 for K-index categories 0–1 and &gt;5, respectively; P-value &lt;0.001).

Conclusion
Considering no evidence of a difference in the number of citations across K-index categories, the stigma associated with higher K-index needs to be reconsidered.
The rise in inequality after pandemics: can fiscal support play a mitigating role?
Authors: Furceri Davide , Loungani Prakash , Ostry Jonathan D , Pizzuto Pietro 
Published: June 2021

Abstract
Major epidemics of the last two decades (SARS, H1N1, MERS, Ebola, and Zika) have been followed by increases in inequality [Furceri et al. (2020), COVID Economics, 12, 138–157]. In this article, we show that the extent of fiscal consolidation in the years following the onset of these pandemics has played an important role in determining the extent of the increase in inequality. Episodes marked by extreme austerity—measured using either the government’s fiscal balance, health expenditures, or redistribution—have been associated with an increase in the Gini measure of inequality three times as large as in episodes where fiscal policy has been more supportive. We survey the evidence thus far on the distributional impacts of the COVID-19 pandemic, which suggests that inequality is likely to increase in the absence of strong policy actions. We review the case made by many observers [IMF (2020), Fiscal Monitor; Stiglitz (2020), Finance & Development, Fall 2020; Sandbu (2020b), Financial Times, 26 November 2020)] that fiscal support should not be withdrawn prematurely despite understandable concerns about high public debt-to-GDP ratios.
Apathy and Anhedonia in Adult and Adolescent Cannabis Users and Controls Before and During the COVID-19 Pandemic Lockdown
Authors: Skumlien Martine , Langley Christelle , Lawn Will , Voon Valerie , Sahakian Barbara J 
Published: June 2021

Abstract

Background
COVID-19 lockdown measures have caused severe disruptions to work and education and prevented people from engaging in many rewarding activities. Cannabis users may be especially vulnerable, having been previously shown to have higher levels of apathy and anhedonia than non-users.

Methods
In this survey study, we measured apathy and anhedonia, before and after lockdown measures were implemented, in n = 256 adult and n = 200 adolescent cannabis users and n = 170 adult and n = 172 adolescent controls. Scores on the Apathy Evaluation Scale (AES) and Snaith-Hamilton Pleasure Scale (SHAPS) were investigated with mixed-measures ANCOVA, with factors user group, age group, and time, controlling for depression, anxiety, and other drug use.

Results
Adolescent cannabis users had significantly higher SHAPS scores before lockdown, indicative of greater anhedonia, compared with adolescent controls (P = .03, η p2 = .013). Contrastingly, adult users had significantly lower scores on both the SHAPS (P &lt; .001, η p2 = .030) and AES (P &lt; .001, η p2 = .048) after lockdown compared with adult controls. Scores on both scales increased during lockdown across groups, and this increase was significantly smaller for cannabis users (AES: P = .001, η p2 = .014; SHAPS: P = .01, η p2 = .008). Exploratory analyses revealed that dependent cannabis users had significantly higher scores overall (AES: P &lt; .001, η p2 = .037; SHAPS: P &lt; .001, η p2 = .029) and a larger increase in scores (AES: P = .04, η p2 =.010; SHAPS: P = .04, η p2 = .010), compared with non-dependent users.

Conclusions
Our results suggest that adolescents and adults have differential associations between cannabis use as well as apathy and anhedonia. Within users, dependence may be associated with higher levels of apathy and anhedonia regardless of age and a greater increase in levels during the COVID-19 lockdown.
Measuring the impacts of the Using Antibiotics Wisely campaign on Canadian community utilization of oral antibiotics for respiratory tract infections: a time-series analysis from 2015 to 2019
Authors: Rolf von den Baumen Teagan , Crosby Michael , Tadrous Mina , Schwartz Kevin L. , Gomes Tara 
Published: June 2021

Abstract

Background
On 1 November 2018, Choosing Wisely Canada launched their Using Antibiotics Wisely primary care campaign, which aimed to reduce unnecessary antibiotic prescriptions for respiratory tract infections (RTIs) through educational tools for patients and providers.

Objectives
We explored the impact of this campaign on antibiotic utilization in Canada.

Methods
We conducted a population-based study in Canada between January 2015 and December 2019. We used interventional autoregressive integrated moving average models to study the impact of the Using Antibiotics Wisely campaign on the prescribing rate (prescriptions per 1000 population) of RTI-indicated antibiotics. We analysed prescription rates overall and stratified by age group, drug class and province, in each month over the study period.

Results
There was a 1.5% reduction in the annual prescribing rate of RTI-indicated antibiotics over the study period, which was generally consistent across age groups and provinces. Following the 2018 Using Antibiotics Wisely clinician toolkit release, we observed no significant change in RTI-indicated antibiotic prescribing rates nationally (P = 0.13). This was consistent by age group (children, P = 0.91; adults, P = 0.58; and older adults, P = 0.67) and drug class (narrow-spectrum penicillins, P = 0.88; macrolides, P = 0.85; broad-spectrum penicillins, P = 0.60; cephalosporins, P = 0.45; tetracyclines, P = 0.55; and fluoroquinolones, P = 0.98). In our secondary analysis of prescription rates in provinces that self-identified as prioritizing Using Antibiotics Wisely, we observed no significant change following the launch of the campaign.

Conclusions
The introduction of the Using Antibiotics Wisely campaign in Canada has not caused a significant change in short-term antibiotic prescribing patterns. Community antibiotic stewardship campaigns that include components beyond education may be more impactful.
A Method That Precisely Pressurizes the Local Limb
Authors: Zhou Jinfeng , Fu Chen , Yang Wengbo , Gu Wenhua 
Published: June 2021

Abstract
Pressure garment treatment (PGT) is currently recognized as an effective method to prevent scar formation or treat scar hyperplasia. Research on PGT remains controversial. These controversies indicate that PGT lacks reliable evidence of evidence-based medicine. Different studies on PGT need to be conducted under the same “gold standard” so that different studies can be compared. We consider this “gold standard” to be that the pressure remains stable within a confidence interval during treatment. We calibrated and verified the reference value of the sensor using a cuff of sphygmomanometer. A pressure-adjustable pressure system was obtained by installing a soft tissue expander on the pressure garment. Local pressure was adjusted by charging and releasing air. Subsequently, the flexible pressure sensor was placed on the upper arm of the healthy volunteers. We validated the compression system on healthy volunteers’ forearms and AO standard prostheses (forearms). The reference value of the sensor was calibrated on Volunteer 1. Measuring repeated on Volunteers 2 and 3. The measurement was very reproducible. The test results in the experimental group showed that the local pressure gradually increased with the increase of the inflation of the airbag. However, the pressure at the opposite position of the forearm changed little. Real-time pressure monitoring and pressure adjustment enable the pressure to be maintained at a certain value. Our study provides a new idea for the production of elastic clothing with the function of pressure measurement and pressure regulation, which may promote the accuracy and reliability of PGT.
How to manage emotional problems
Authors: Budson Andrew E. , O’Connor Maureen K. 
Published: June 2021

Abstract
It is important to address your loved one’s emotional problems. Learn to recognize the signs of depression and anxiety. Common symptoms of depression include feelings of sadness, worthlessness or guilt; fixating on past failures; being tearful; irritability or frustration, even over small matters; memory difficulties; trouble concentrating; sleep difficulties; daytime fatigue and lack of energy; changes in appetite; often wanting to stay home; physical slowing; physical aches or pains; loss of interest in activities; loss of interest in sex; loss of interest in living; hopelessness about the future; frequent thoughts of death. Help them to deal with the sadness and frustration that often come with declining abilities. Start by improving your loved one’s abilities and adjust tasks to make them easier. Treat depression and anxiety with aerobic exercise, meditation, relaxation, and talk therapy.
Introduction
Authors: Rodin Gary , Hales Sarah 
Published: June 2021

Abstract
This introduction outlines the structure of the Managing Cancer and Living Meaningfully (CALM) book and presents an overview of core CALM concepts and research. Part I of the book outlines the theoretical framework and research that has informed the development of CALM. Part II contains the CALM manual, which presents the specific content and process of CALM. Our path to the development of CALM is described and the four CALM domains are introduced alongside the CALM evidence base.
Military Medical Ethics and Just War
Authors: Gross Michael L. 
Published: June 2021

Abstract
The goal of military medicine is to conserve the fighting force necessary to prosecute just wars. Just wars are defensive or humanitarian. A defensive war protects one’s people or nation. A humanitarian war rescues a foreign, persecuted people or nation from grave human rights abuse. To provide medical care during armed conflict, military medical ethics supplements civilian medical ethics with two principles: military-medical necessity and broad beneficence. Military-medical necessity designates the medical means required to pursue national self-defense or humanitarian intervention. While clinical-medical necessity directs care to satisfy urgent medical needs, military-medical necessity utilizes medical care to satisfy the just aims of war. Military medicine may, therefore, attend the lightly wounded before the critically wounded or use medical care to win hearts and minds. The underlying principle is broad, not narrow, beneficence. The latter addresses private interests, while broad beneficence responds to the collective welfare of the political community.
Transradial Approach for Stroke
Authors: Chen Stephanie H. , Jabbour Pascal M. , Peterson Eric C. 
Published: June 2021

Abstract
Performing a mechanical thrombectomy via the radial approach is a critical skill to be learned in the armamentarium of the neurointerventionalist. In addition to potential safety advantages, patient anatomy often renders femoral access to the internal carotid artery impossible. Morbid obesity, severe aortic arch tortuosity, or aortofemoral occlusive disease can cause significant delays in accessing the target vessel or even complete failure. There are unique challenges to performing mechanical thrombectomy via the radial approach, given the need for speed and qualified metrics of technical success. The technical nuances and pearls of performing a mechanical thrombectomy via the radial approach are reviewed.
Drug Treatments
Authors: Taylor Eric 
Published: June 2021

Abstract
This chapter describes the use of medication in alleviating the problems of young people with neurodevelopmental disorders. It gives special emphasis to its use in multiple overlapping conditions and to the long-term impact on functioning. Stimulant and non-stimulant medications for the control of inattention and hyperactivity are reviewed. Antipsychotics for control of agitation and aggression, as well as for the treatment of psychosis, are considered. Pharmacological management of mood and anxiety problems is covered in the context of people with neurodevelopmental disorders. Control of tics, other movement disorders, and sleep problems are included. Practical considerations of prescribing are covered, and cautions about safety include descriptions of adverse events and how to reduce them.
Properties of cold molecular gas in four type-1 active galaxies hosting outflows
Authors: Runnoe Jessie C , Gültekin Kayhan , Rupke David , López-Sepulcre Ana 
Published: June 2021

ABSTRACT
Feedback from active galactic nuclei (AGN) has proven to be a critical ingredient in the current picture of galaxy assembly and growth. However, observational constraints on AGN-driven outflows face technical challenges and as a result, the cold molecular gas outflow properties of type-1 AGN are not well known. We present new IRAM NOrthern Extended Millimeter Array observations of CO$\, (1{-}0)$ in F07599+6508, Z11598 − 0112, F13342 + 3932, and PG1440 + 356, all nearby type-1 AGN and ultraluminous infrared galaxies. We achieve spatial resolution of 1–3 arcsec corresponding to physical scales of 2–8 kpc and spectral resolution of 15–60  km s−1, which enables updated CO$\, (1{-}0)$ redshifts and a detailed morphological view of the cold molecular gas in these sources. The CO$\, (1{-}0)$ luminosities, $L_{CO}^{\prime }$, are in the range 2–12 × 109 K km s−1 pc2 and inferred molecular gas masses, M(H2), are in the range 2–9 × 109 M⊙. The velocity fields and gas distributions do not unambiguously identify any of these sources as having outflows. However, Z11598 − 0112 has signs of infalling material and after the subtraction of a rotating disc model PG 1440 + 356 shows complex kinematics in the residuals that may indicate an outflow or warped disc.
On the Nitrogen variation in ∼2 Gyr old massive star clusters in the large Magellanic Cloud
Authors: Martocchia S , Lardo C , Rejkuba M , Kamann S , Bastian N , Larsen S , Cabrera-Ziri I , Chantereau W , Dalessandro E , Kacharov N , Salaris M 
Published: June 2021

ABSTRACT
We present ESO/VLT FORS2 low resolution spectroscopy of red giant branch stars in three massive intermediate age (∼1.7–2.3 Gyr) star clusters in the Large Magellanic Cloud. We measure CH and CN index bands at 4300 Å  and 3883 Å, as well as [C/Fe] and [N/Fe] abundance ratios for 24, 21, and 12 member stars of NGC 1978, NGC 1651, and NGC 1783, respectively. We find a significant intrinsic spread in CN in NGC 1978 and NGC 1651, a signal of multiple stellar populations (MPs) within the clusters. On the contrary, we report a null CN spread in NGC 1783 within our measurement precision. For NGC 1978, we separated the two populations in the CN distribution and we translated the CN spread into an internal N variation Δ[N/Fe] = 0.63 ± 0.49 dex. For NGC 1651 and NGC 1783, we put upper limits on the N abundance variations of Δ[N/Fe] ≤ 0.2, 0.4 dex, respectively. The spectroscopic analysis confirms previous results from HST photometry, where NGC 1978 was found to host MPs in the form of N spreads, while slightly younger clusters (e.g. NGC 1783, &lt; 2 Gyr old) were not, within the limits of the uncertainties. It also confirms that intermediate age massive clusters show lower N abundance variations with respect to the ancient globular clusters, although this is in part due to the effect of the first dredge up at these stellar masses, as recently reported in the literature. We stress the importance of future studies to estimate the initial N abundance variations, free of stellar evolutionary mixing processes, by observing unevolved stars in young clusters.