bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pneumothorax in COVID-19 – A New Challenge
Authors: Bhandari Sudhir , Rankawat Govind , Singh Ajeet 
Published: October 2021

Background: Coronavirus disease 2019 mainly affect the lungs which can complicate into pneumothorax and require hospitalization. We aimed to discuss the presence of pneumothorax and its possible risk factors in vulnerable patients of COVID-19 to establish an effective preventive and therapeutic strategy for this fatal complication.
Methods: This retrospective observational study included 30 admitted patients of COVID-19 associated pneumothorax. The patient’s data concerning demography, clinical manifestation, associated medical illness, point of onset of pneumothorax, mode of oxygenation with FiO2 and PEEP, radiological imaging, and outcome were extracted from their medical records. All collected data were tabulated, compiled, and analyzed to establish possible causality of pneumothorax.
Results: All patients of the study group exhibited symptomatic presentations, 73% of patients had severe clinical conditions and 24 patients also had associated chronic medical illness. In our study pneumothorax developed 3rd week onwards after symptoms onset with a mean time of pneumothorax was found to be 23.96 days (23.96±8.06). At the point of diagnosis of pneumothorax, 22 patients were on non-invasive ventilation, 6 on high flow mask, and 2 patients on invasive ventilation, these patients required higher FiO2 (77.66%) and higher PEEP (10.83 cmH2O) to maintain PaO2 within normal range. All patients had raised COVID-related inflammatory markers viz. NLR, D-dimer, CRP, IL-6, and these markers showed a positive correlation with the duration of hospital stay in patients of pneumothorax.
Conclusion: Pneumothorax can be suspected in COVID-19 infected patients having severe COVID-19 pneumonia of longer duration with assistant ventilation and raised inflammatory markers going to rapid worsening of symptoms.
LAPROSCOPIC COMMON BILE DUCT EXPLORATION: STENT DRAINAGE VERSUS T- TUBE DRAINAGE
Authors: Kumar Gulshan 
Published: October 2021

Introduction: One of the safe & feasible methods for the management of extra-hepatic bile duct calculi is laparoscopic bile duct exploration. Around 10-15% of the subjects who have surgery due to gallstone disease have choledocholithiasis associated with it. A standard procedure to prevent bile escape from the choledochotomy site is conventionally postoperative T-tube drainage following common bile duct exploration.
Aims & Objectives: Comparative study of laproscopic common bile duct exploration using stent drainage versus t- tube drainage.
Material & Methods: The study involved a total of 46 subjects with choledocholithiasis, who were categoryed in 2 categorys. Category I as a drainage category of stents and Category 2 as a drainage category of T-tubes. The subjects in both classes underwent LCBDE surgery. Of the 46 subjects operated, 23 were in category I (stent drainage category) and 23 were in category 2 (T-tube drainage category).
Results: 23 subjects were categoryed in the stent drainage and T-tube drainage categories, respectively. In both classes, no perioperative or postoperative mortality was reported. Subjects had hypertension in stent drainage category 4 (17.39 percent) and 5 (21.73 percent) suffered from diabetes as a comorbid disease, while 2 (8.69 percent) subjects had jaundice. Four (17.39 percent) subjects with diabetes and three (13.04 percent) subjects with jaundice were found in T-tube drainage category 3 (13.04 percent) with hypertension. In both classes, no statistically significant difference was found. In terms of organisational results and outcomes, statistically significant variations were found in both categorys (Table 3). Mean operating time was 103± 22.4 in category I while 127±32.7 (P value < 0.005) in category II. In the Stent Drainage Category, blood loss during procedure was 22±3.7 ml, while in the T-tube drainage category it was 38±5.1 (P value < 0.005).
Conclusion. After laparoscopic choledochotomy, primary closure of the bile duct with spontaneously reversible biliary stent placement is a viable and practicable process. With spontaneously removable biliary stents, less surgery time, less bleeding and less intestinal complications have been observed.
Keywords: stent drainage, T- tube drainage, choledochotomy
Effect of biostimulant on yield characters of common bean cultivars under Southwestern Goiás conditions
Authors: Carvalho Ivan Ricardo , Ferreira Luiz Leonardo Ferreira , Conte Giordano Gelain , Amaral Gileade Costa Leonel , Campos Juliana Naves , Tomazele Augusto Antonio Souza , Carrijo Núbia Sousa , Pereira Valúcia Teodoro , Souza Adriano Teixeira , Loro Murilo Vieira 
Published: October 2021

This study aimed to evaluate the effect of biostimulant positioning on common bean cultivars in the southwestern Goiás conditions. The experiment was conducted in the municipality of Mineiros-GO. The experimental design was a randomized block in factorial 6x3, corresponding to the positioning of the Triplus® biostimulator (R5, R5 + R8 and water) in six common bean cultivars (BRS Campeiro, BRS Esteio, BRS Estilo, BRS Marfim, BRS Notavel and BRS Perola) in 4 replicates. The following productive attributes were evaluated: number of pod, number total of grains, number of commercial grains, number of non-commercial grains, mass of commercial grains, thousand grains mass. There was a significant interaction between cultivar x biostimulant as well as the factors alone. At the end of the experiment, it was concluded that the positioning of the biostimulant via foliar in the R5 phenological phase provided the highest yields for all common bean cultivars, especially BRS Estilo (43.87 sc ha-1) and BRS Notavel (43.02 sc ha-1). Biostimulant applications at stage R5 promoted the best results for number of non-commercial grains, mass of commercial grains, thousand grains mass. In the three stratifications used in the dendrogram, it was possible to form two groups of genotypes. Number total of grains, number of commercial grains and number of pod positively correlate with yield.
EFEKTIFITAS PENGGUNAAN HANDPHONE DALAM MENINGKATKAN MINAT BERKONSULTASI SISWA SMP (STUDI KASUS DI SMP NEGERI 2 BELO)
Authors: Khairunnisa Khairunnisa 
Published: October 2021

The implementation of guidance and counseling services should take place in comfortable and conducive conditions. Guidance and counseling is expected to develop one's potential and competence in the community to be able to fulfill their duties optimally. In addition, in helping individuals overcome various problems that can interfere with its development[1]. This research is motivated by many students who feel afraid when called by counseling and guididance teachers, let alone have to come to the counseling room to consult or sharing probem. The lack of interest in consulting students was allegedly due to various factors. One of them is due to the lack of socialization conducted by counseling and guidance teachers in introducing what and how counseling and guidance is. If this socialization can be carried out well, it will at least give a clear picture to students that the counseling and guidance is present as a forum and student's friend while studying. Efforts that can be done include: Able to familiarize yourself with students and be able to position yourself as friends, and improve counseling skills so as to improve verbal and non verbal communication skills, express problems, understand problems and accept students. So that these efforts are maximized, the counseling and guidance teacher can use the media as a tool, one of which can be through the help of media, namely mobile phones. To get rid of these feelings, the BK teacher uses mobile media as a communication tool to consult with students. This study aims to determine whether the use of mobile phones is effective in increasing the interest in consulting students of STATE 2ND JUNIOR HIGH SCHOOL. The approach used in this study is qualitative research that is shown to describe and describe existing phenomena that are scientific[2]. While the type of research used is descriptive research. This research was conducted in SMP NEGERI 2 BELO, the research subjects were 2 counseling and guidance teachers and 5 students who had used mobile phones in consulting services. The method of data collection is done by observation, interviews, and documentation. Analysis of data using qualitative descriptive by interpreting the data obtained. The research shows that the process of using mobile phones in increasing the interest in consulting students of SMP NEGERI 2 BELO is carried out in stages, starting from the preparation stage consisting of media and socialization selection, then the implementation stage consists of identification, giving outreach and evaluating both the process and the results. Based on the results of the study, the researchers can conclude that the use of mobile phones is effective in increasing the interest in consulting students of SMP Negeri 2 BELO
Efektivitas Model Experiential Learning Untuk Meningkatkan Keterampilan Mengelola Emosi Marah
Authors: Nurhayati Nurhayati , - Faijin , - Amiruddin , Indah Sulistia 
Published: October 2021

Rasa marah merupakan bagian dari emosi yang dimiliki oleh semua individu, dalam kadar tertentu hampir setiap individu pernah mengalaminya. Terkadang individu sulit untuk mengontrol emosi marah, hal itu tergantung dari keterampilan individu dalam mengelola emosi marah yang muncul, oleh karena itu, guru BK perlu memberikan latihan agar peserta didik memiliki keterampilan dalam mengelola emosi marah melalui teknik tertentu. Tujuan penelitian untuk mengetahui keefektifan model experiential learning untuk melatih keterampilan pengelolaan emosi marah. Rancangan penelitian ini menggunakan True Experimental Pre-test, Posttest Control Group Design. Populasi penelitian adalah peserta didik SMP Negeri 6 Kota Bima kelas VII. Subjek penelitian terjaring secara random sehingga diperoleh sejumlah 10 orang yang dibagi ke dalam kelompok eksperimen (n = 5) dan kelompok kontrol (n = 5). Instrumen lain yang digunakan adalah lembar penilaian diri, lembar tugas mengelola emosi marah dan pedoman observasi. Teknik statistik yang digunakan untuk menguji hipotesis adalah Two Independent Sample Test Mann Whitney untuk membandingkan perbedaan skor keterampilan pengelolaan emosi marah antara kelompok eksperimen dan kelompok kontrol. Hasil analisis menunjukkan bahwa nilai koefisien Z (-2.207) dengan signifikansi sebesar 0.027 yang berarti 0.027 di bawah nilai probabilitas yaitu (0.027 < 0.05). Berdasarkan hasil uji statistik tersebut dapat disimpulkan bahwa H0 ditolak yang berarti ada perbedaan yang signifikan antara peserta didik yang diintervensi dengan model experiential learning dan peserta didik yang diintervensi dengan bimbingan secara umum, sehingga model experiential learning efektif untuk meningkatkan keterampilan pengelolaan emosi marah peserta didik SMP. Hasil pelatihan menunjukan bahwa model experiential learning bisa untuk mengajarkan keterampilan mengelola emosi marah peserta didik SMP
Pengaruh Peer Group Terhadap Motivasi Belajar Siswa SMP Negeri 8 Kota Bima
Authors: Amin Nur Syariful , Khairunnisa Khairunnisa , Indah Sulistia 
Published: October 2021

Peer group adalah sekelompok teman sebaya yang mempunyai ikatan emosional yang kuat dan mereka dapat berinteraksi, bergaul, bertukar pikiran, dan pengalaman dalam memberikan perubahan dan pengembangan dalam kehidupan sosial dan pribadi anggota.Sedangkan motivasi pada dasarnya dapat membantu dalam memahami dan menjelaskan perilaku individu termasuk perilaku individu yang sedang belajar. Penelitian ini ditujukan untuk mengetahui pengaruh peer group terhadap motivasi belajar siswa.
Penelitian ini dilakukan di SMP Negeri 8 Kota Bima . Subyek dalam penelitian ini yaitu seluruh siswa kelas VIII yang tergabung dalam 8 peer group dengan jumlah 31 orang siswa. Penelitian ini termasuk penelitian kuantitatif karena menggunakan rancangan empiris dan gejala yang diamati telah ada secara wajar tampa harus memanipulasi terlebih dahulu. Instrumen pengumpulan data dalam penelitian ini adalah observasi, angket dan dokumentasi. Angket dianalisa dengan menggunakan analisis statistik deskriptif melalui rumus korelasi product moment. Dari hasil analisis data kualitatif diketahui bahwa nilai korelasi product moment (r) adalah 0,43 (43%). Sehingga dengan menggunakan kaidah pengambilan keputusan dalam uji statistik maka dapat disimpulkan bahwa hipotesis alternatif (Ha) yang berbunyi : ada pengaruh peer group terhadap motivasi belajar siswa di SMPN 8 Kota Bima, dapat diterima
PENGARUH PEMBERIAN PUPUPK HAYATI DAUN KERSEN TERHADAP PERTMBUHAN TANAMAN TOMAT (Solanum lyicopersicum L)
Authors: Azmin Nikman Nikman , Hartati Hartati , Bakhtiar Bakhtiar 
Published: October 2021

Tanaman tomat (Solanun lycopersicum L) merupakan tanaman holtikultura yang banyak dikembangkan oleh para petani, selain itu tanaman tomat kaya akan nutrisi dan paling banyak digemari dan dikonsumsi serta semakin tingginya permintaan pasar sehingga banyak orang yang bembudidayakan tanaman tomat, namun pada kenyataanya tomat yang dibudidayakan di Indonesia umumnya hanya digunakan satu jenis pupuk saja. Dalam rangka meningkatkan proses pertumbuhan tomat, maka diperlukan rekayasa edafik yaitu dengan Pemberian Pupuk Hayati dari Daun Kersen. Tujuan penelitian ini untuk mengetahui pertumbuhana tanaman tomat dengan pemberian berbagai dosis pupuk hayati daun kersen yang tepat, diharapkan dapat mendukung keberhasilan tumbuhan. Penelitian ini dapat dilakukan pada Februari sampai Mei 2020. Rancangan penelitian yang digunakan adalah Rancangan acak kelompok (RAK) dengan 5 perlakuan dan 3 ulangan untuk masing-masing perlakuan, sehingga terdapat 15 kombinasi percobaan. Sampel yang digunakan dalam penelitian ini adalah 150 benih tanaman tomat. Dengan parameter yang diteliti adalah tinggi tanaman, jumlah daun, jumlah cabang. Hasil penelitian menunjukan bahwa pemberian pupuk hayati dari daun kersen dengan dosis yang berbeda terhadap pertumbuhan pada tanaman tomat berpengaruh secara signifikan. Pada tanaman terbaik diperoleh pada perlakuan P4 dosis pupuk 40cc/liter air dengan hasil tinggi tanaman pada umur 28 HST 153,33 cm dan jumlah daun terbanyak diperoleh pada perlakuan dosis 40cc/liter air dengan hasil rata-rata jumlah daun pada umur 28 HST adalah 63,3 Helai
Real-Time Monitoring of Dissection Events of Single Budding Yeast in a Microfluidic Cell-Culturing Device Integrated With Electrical Impedance Biosensor
Authors: Zhu Zhen , Geng Yangye , Wang Yingying , Liu Ke , Yi Zhenxiang , Zhao Xiangwei , Ouyang Shuiping , Zheng Ke , Fan Yimin , Wang Zixin 
Published: October 2021

Microfluidic devices in combination with fluorescent microscopy offer high-resolution and high-content platforms to study single-cell morphology, behavior and dynamic process in replicative aging of budding yeast, Saccharomyces cerevisiae. However, a huge mass of recorded images makes the data processing labor-intensive and time-consuming to determine yeast replicative lifespan (RLS), a primary criterion in yeast aging. To address this limitation and pursue label-free RLS assays, electrical impedance spectroscopy (EIS) that can be easily functionalized through microelectrodes in microfluidic devices, was introduced to monitor cell growth and division of budding yeast. Herein, a microfluidic device integrated with EIS biosensor was proposed to perform in-situ impedance measurement of yeast proliferation in single-cell resolution so as to identify the momentary events of daughter dissection from its mother. Single yeast cells were reliably immobilized at the bottleneck-like traps for continuous culturing, during which daughter cells were effectively detached from their mother cells by hydraulic shear forces. Time-lapse impedance measurement was performed every 2 min to monitor the cellular process including budding, division and dissection. By using the K-means clustering algorithm to analyze a self-defined parameter “Dissection Indicator,” to our knowledge for the first time, the momentary event of a daughter removing from its mother cell was accurately extracted from EIS signals. Thus, the identification of daughter dissection events based on impedance sensing technology has been validated. With further development, this microfluidic device integrated with electrical impedance biosensor holds promising applications in high-throughput, real-time and label-free analysis of budding yeast aging and RLS.
Comprehensive Analysis of N6-Methyladenosine RNA Methylation Regulators Expression Identify Distinct Molecular Subtypes of Myocardial Infarction
Authors: Shi Xin , Cao Yaochen , Zhang Xiaobin , Gu Chang , Liang Feng , Xue Jieyuan , Ni Han-Wen , Wang Zi , Li Yi , Wang Xia , Cai Zhaohua , Hocher Berthold , Shen Ling-Hong , He Ben 
Published: October 2021

Background: Myocardial infarction (MI) is one of the leading threats to human health. N6-methyladenosine (m6A) modification, as a pivotal regulator of messenger RNA stability, protein expression, and cellular processes, exhibits important roles in the development of cardiac remodeling and cardiomyocyte contractile function.Methods: The expression levels of m6A regulators were analyzed using the GSE5406 database. We analyzed genome-wide association study data and single-cell sequencing data to confirm the functional importance of m6A regulators in MI. Three molecular subtypes with different clinical characteristics were established to tailor treatment strategies for patients with MI. We applied pathway analysis and differentially expressed gene (DEG) analysis to study the changes in gene expression and identified four common DEGs. Furthermore, we constructed the protein–protein interaction network and confirmed several hub genes in three clusters of MI. To lucubrate the potential functions, we performed a ClueGO analysis of these hub networks.Results: In this study, we identified that the levels of FTO, YTHDF3, ZC3H13, and WTAP were dramatically differently expressed in MI tissues compared with controls. Bioinformatics analysis showed that DEGs in MI were significantly related to modulating calcium signaling and chemokine signaling, and m6A regulators were related to regulating glucose measurement and elevated blood glucose levels. Furthermore, genome-wide association study data analysis showed that WTAP single-nucleotide polymorphism was significantly related to the progression of MI. In addition, single-cell sequencing found that WTAP is widely expressed in the heart tissues. Moreover, we conducted consensus clustering for MI in view of the dysregulated m6A regulators’ expression in MI. According to the expression levels, we found MI patients could be clustered into three subtypes. Pathway analysis showed the DEGs among different clusters in MI were assigned to HIF-1, IL-17, MAPK, PI3K-Akt signaling pathways, etc. The module analysis detected several genes, including BAG2, BAG3, MMP2, etc. We also found that MI-related network was significantly related to positive and negative regulation of angiogenesis and response to heat. The hub networks in MI clusters were significantly related to antigen processing and ubiquitin-mediated proteolysis, RNA splicing, and stability, indicating that these processes may contribute to the development of MI.Conclusion: Collectively, our study could provide more information for understanding the roles of m6A in MI, which may provide a novel insight into identifying biomarkers for MI treatment and diagnosis.
Green Synthesis of pH-Responsive, Self-Assembled, Novel Polysaccharide Composite Hydrogel and Its Application in Selective Capture of Cationic/Anionic Dyes
Authors: Srivastava Nandita , Roy Choudhury Anirban 
Published: October 2021

Dyes are one of the most hazardous chemicals causing significant environmental pollution and affecting water quality. Majority of the existing methods for dye removal and degradation involve synthetic membranes and use of hazardous chemicals, further resulting in secondary pollution. The present study reports polysaccharide based novel composite hydrogel as biodegradable matrix for pH-responsive selective adsorption of cationic/anionic dyes. This membrane showed pH-responsive adsorption of methyl green (MG) and methyl orange (MO) with similar adsorption equilibrium, i.e., 315 and 276 mg g−1, respectively. Interestingly, selective adsorption at different pH has allowed separation of dye mixtures that holds incredible industrial importance for dyes recovery. The hydrogel matrix was able to completely separate MG, a model cationic dye at neutral pH from the dye mixture whereas, it was possible to remove 60% MO, a model anionic dye at acidic pH. Furthermore, comprehensive isothermal and kinetic studies of adsorption revealed that Freundlich isotherm describing the multilayer coverage and pseudo-second-order kinetics were followed. Thermodynamic studies indicated that the adsorption process was spontaneous and endothermic. In fact, the membrane was reusable for at least ten cycles and exhibited desorption efficiency of 80 and 60% for MO and MG, respectively, which may be further recycled to make the process environmentally sustainable. Overall, this study proposes an inexpensive, simple, biologically safe, and efficient adsorbent material for dye effluent treatment.
Assessment of Therapeutic Response to Statin Therapy in Patients With Intracranial or Extracranial Carotid Atherosclerosis by Vessel Wall MRI: A Systematic Review and Updated Meta-Analysis
Authors: Zhou Pengyu , Wang Yuting , Sun Jie , Yu Yannan , Mossa-Basha Mahmud , Zhu Chengcheng 
Published: October 2021

Background and Aims: Statin therapy is an essential component of cardiovascular preventive care. In recent years, various vessel wall MRI (VW-MRI) techniques have been used to monitor atherosclerosis progression or regression in patients with extracranial or intracranial large-artery atherosclerosis. We aimed to perform a systematic review and meta-analysis on the effects of statin therapy on plaque evolution as assessed by VW-MRI.Materials and Methods: Prospective studies investigating carotid and intracranial atherosclerotic plaques in patients on statin therapy monitored by serial VW-MRI were systematically identified in the literature. The plaque burden and lipid-rich necrotic core (LRNC) volume of carotid plaque and the imaging features of intracranial plaques were extracted and summarized. For studies investigating carotid artery wall volume and LRNC volume, combined estimates were derived by meta-analysis.Results: The study identified 21 studies of carotid plaque and two studies of intracranial plaque. While 16 studies investigating carotid plaques that included 780 patients by High-resolution VW-MRI were included in the meta-analysis. There was no significant change in carotid wall volume from baseline to 12 months. A significant change in LRNC volume was observed at &gt; 12 months compared with baseline (Effect = −10.69, 95% CI = −19.11, −2.28, P &lt; 0.01), while no significant change in LRNC volume at 3–6 months or 7–12 months after statin therapy initiation in 6 studies. Increases in fibrous tissue and calcium and reduction in neovascularization density of the plaque were seen in 2/3 studies (including 48/59 patients), 1/3 studies (including 17/54 patients), and 2/2 studies (including 71 patients) after statin therapy, respectively. Two studies with 257 patients in intracranial atherosclerosis showed that statins could effectively decrease wall volume and plaque enhancement volume.Conclusions: Collective data indicated that statins could potentially stabilize carotid plaques by significantly reducing LRNC with 1 year of therapy as shown on serial carotid VW-MRI. There was no significant decrease in wall volume, which nonetheless indicated that plaque composition changes might be more sensitive to response monitoring than wall volume. It is likely that more sensitive, clinically relevant, and preferably quantitative indicators of therapeutic effects on intracranial vessel plaque morphology will be developed in the future.