bluuebunny/crossref_metadata_2025_split huggingface dataset:
H2S Exposure Aggravates Inflammation Induced by LPS in Chicken Liver By microRNA-216a/PKCα Axis Modulating NF-κB/TNFα Pathway
Authors: Guo Jinming , Zhu Wenjing , Yin Yilin , Shi Xu , Xu Shi-wen 
Published: November 2021

Abstract
Background: Hydrogen sulfide (H2S), a common air pollutant and toxic gas, which is harmful to organisms and the environment. Exposure to high concentrations of H2S can lead to necrosis and inflammation. However, the potential mechanism of H2S-induced hepatotoxicity and the role of microRNA (miRNA) in this process are still poorly understood. In this experiment, 80 one-day-old chickens were used as model organisms to evaluate the effects of H2S and Lipopolysaccharide (LPS) on poultry liver. Four groups (Control group, LPS group, H2S group, H2S-LPS group) were established. Liver tissue was collected after 42 days of age. Ultrastructural observation, pathological tissue observation, immunofluorescence analysis, real-time quantitative PCR analysis and Western blot analysis were used to detect.Results: The results showed that obvious pyroptosis was observed in ultrastructure. Histopathological observation showed obvious necrosis and inflammatory injury in broiler liver tissue. By detecting the expression of miR-216a in the four groups, we verified that miR-216a can target chicken PKCα. Molecular level studies showed that H2S exposure could inhibit the expression of miR-216a, promote the up-regulation of PKCα, activate the NF-κB/TNFα signaling pathway, induce cell necrosis (necrosis marker factors RIP1, RIP3, caspase8, MLKL, NLRP3) and pyroptosis-related gene expression (ASC, caspase1, GSDMD), and eventually lead to inflammatory injury of chicken liver (IL-1β, IL-6, IL-18, iNOS).Conclusions: We concluded that H2S induced the imbalance of the NF-κB/TNFα signaling pathway through miR-216a/PKCα axis, leading to chicken liver necrosis and cell pyroptosis, and further causing inflammatory injury. Notably, we also found that H2S aggravated LPS-induced liver inflammation. This study can provide reference to the pathological mechanism of animal damage and poultry poisoning caused by H2S pollution in the atmospheric environment.
Advances In The Modeling And Dynamic Simulation of Reeving Systems Using The Arbitrary Lagrangian-Eulerian Modal Method
Authors: Escalona José L. , Mohammadi Narges 
Published: November 2021

Abstract
This paper presents new advances in the arbitrary Lagrangian-Eulerian modal method (ALEM) recently developed for the systematic simulation of the dynamics of general reeving systems. These advances are related to a more convenient model of the sheaves dynamics and the use of axial deformation modes to account for non-constant axial forces within the finite elements. Regarding the sheaves dynamics, the original formulation uses kinematic constraints to account for the torque transmission at the sheaves by neglecting the rotary inertia. One of the advances described in this paper is the use of the rotation angles of the sheaves as generalized coordinates together with the rope-to-sheave no-slip assumption as linear constraint equations. This modeling option guarantees the exact torque balance the sheave without including any non-linear kinematic constraint. Numerical results show the influence in the system dynamics of the sheave rotary inertia. Regarding the axial forces within the finite elements, the original formulation uses a combination of absolute position coordinates and transverse local modal coordinates to account for the rope absolute position and deformation shape. The axial force, which only depends on the absolute position coordinates, is constant along the element because linear shape functions are assumed to describe the axial displacements. For reeving systems with very long rope spans, as the elevators of high buildings, the constant axial force is inaccurate because the weight of the ropes becomes important and the axial force varies approximately linearly within the rope free span. To account for space-varying axial forces, this paper also introduces modal coordinates in the axial direction. Numerical results show that a set of three modal coordinates in the axial direction is enough to simulate linearly varying axial forces.
Optimierung, Evidenzbasierung, Datafizierung
Authors: Altenrath Maike , Hofhues Sandra , Lange Jennifer 
Published: November 2021

Zahlen, Daten und Algorithmen optimieren Lehren und Lernen zunehmend. In der Schule werden sie u. a. genutzt, um Gestaltungs- und Steuerungsanforderungen an Schulentwicklungsprozessen zu unterstützen. Dabei kommt ein kritischer Blick auf das Verhältnis von Optimierung, Evidenzbasierung und Datafizierung vielfach zu kurz. Ziel des Beitrages ist es daher, dieses Verhältnis auf Basis eines systematischen Reviews aus Sicht kritischer Medienpädagogik in den Blick zu nehmen und für den Diskurs aufzuarbeiten. Verfolgt wird die Fragestellung: Wie gestaltet sich das Verhältnis von Daten und Schulentwicklung im internationalen Diskurs? Die Ergebnisse zeigen, dass Schwerpunktsetzungen auf evidenzbasierter Schulentwicklung liegen. Leerstellen werden in Auseinandersetzungen mit technisch erzeugten, unsystematisch erhobenen Daten gesehen. Während meist die ‹bestmögliche› Nutzung digitaler Daten fokussiert wird, werden tiefgreifende Transformationsprozesse von Schule und Schulentwicklung wenig thematisiert.
Activation of peroxymonosulfate by CuCo2O4 nano-particles towards long-lasting removal of atrazine
Authors: Yin Haoxiang , Li Jun , Yan Haoding , Cai Hanying , Wan Yanjian , Yao Gang , Guo Yong , Lai Bo 
Published: November 2021

Abstract
The effect of peroxymonosulfate (PMS) activated by nanocrystalline CuCo2O4 (NPS) on removal of atrazine (ATZ) was studied. First, the main experimental parameters were studied, including CuCo2O4 dose, PMS dose, initial pH value, and co-existing ion. The removal of ATZ (&gt;99%) was attained under the optimal conditions (i.e., 150 mg/L CuCo2O4, 0.2 mM PMS, 5 mg/L ATZ, initial pH value of 6.8, and reaction time of 30 min). However, the removal of ATZ only reached 20.9% in the PMS alone system and there was no significant ATZ removal when adding CuCo2O4 alone into the solution, proving the good performance of the CuCo2O4/PMS system. Furthermore, reusability of CuCo2O4 was tested through five consecutive runs. To confirm which main active radicals were responsible in the system, two radical quenching experiments were carried out and electron paramagnetic resonance (EPR) was tested. In addition, the characterization of fresh and reacted CuCo2O4 NPs was tested by SEM, TEM, EDS, XRD, and XPS. Subsequently, based on the characterization of CuCo2O4 NPs and identification of radicals, ≡Cu2+/ ≡ Cu+ and ≡Co3+/ ≡ Co2+ were considered to be the main catalytic species, while the synergistic effect of Cu and Co played a crucial role. Finally, the degradation pathway of ATZ was proposed.
ESPAÇO MULTIPICS: A UTILIZAÇÃO DAS PRÁTICAS INTEGRATIVAS E COMPLEMENTARES COMO ESTRATÉGIA DE CUIDADO NA ATENÇÃO À SAÚDE DO TRABALHADOR
Authors: Gondin da Silva Igor , Louise Pereira Estéfany , Fernandes da Silva Claudenir , Marcelino Soares de Brito Kézia 
Published: November 2021

Introdução: As Práticas Integrativas e Complementares em Saúde foram regulamentadas no Sistema Único de Saúde, através da portaria nº 971/2006 que aprova a implantação da Política Nacional de Práticas Integrativas e Complementares, com o objetivo de garantir cuidado continuado, humanizado e integral em saúde, com ênfase na atenção primária. Objetivo: Relatar a experiência vivenciada por uma equipe de Residentes Multiprofissionais em Saúde, através do espaço MULTIPICS em uma Unidade Hospitalar na região do Seridó, Rio Grande do Norte/RN. Metodologia: Trata-se de um estudo descritivo com abordagem quantitativa e qualitativa do tipo relato de experiência. Desenvolvido a partir da vivência de uma equipe de Residentes em Atenção Básica da (EMCM/ UFRN), atuantes no município de Caicó-RN em parceria com o Hospital Regional do Seridó (HRS). As ações foram realizadas durante os meses de março e abril de 2021 por meio do espaço MULTIPICS. As práticas desenvolvidas foram ventosaterapia, musicoterapia, arteterapia, meditação guiada e aromaterapia. Após as práticas foi aplicado um questionário semi-estruturado, sobre seu conhecimento sobre as PICS, nível de satisfação e uma descrição subjetiva da experiência e estado atual após a prática. Resultados: Participaram das ações propostas 57 profissionais, dentre eles (84,21%) mulheres e (15,79%) homens, de vários setores da unidade hospitalar. 10,53% relataram desconhecer as práticas de um modo geral e 89,47% relataram não conhecer as práticas que foram ofertadas. De acordo com a pesquisa de satisfação, 98,25% dos profissionais relataram sentir-se "muito satisfeitos" e "satisfeitos", enquanto somente 1,75% consideraram as práticas "neutras". Os profissionais referiram, também, sensação de harmonia, bem-estar e de paz interior. Conclusões: Por meio da atuação foi possível ofertar um momento de relaxamento no ambiente de trabalho. Obtendo-se após a prática um feedback positivo dos participantes sobre os resultados dessa atuação acerca do seu bem-estar.
Performance Improvement of Box Girder Construction on Toll Road Projects based on M-PERT and VE
Authors: Husin Albert Eddy , Rahmawati Diah Ika , Meisaroh Myrna , Kussumardianadewi Bernadette Detty 
Published: November 2021

Background:
According to the 2019 Global Competitiveness Index (CGI) by the World Economic Forum, the infrastructure growth of Indonesia is placed on number 72 out of 141 countries and ranked 5th in the ASEAN countries. The growth of infrastructure in Indonesia is a result of the imbalance increase of developments of 10-55% annually with only a 1.9% annual increase in road length. There was a delay of 11.95%, with the high investment in the construction of this toll road and the low-interest rate of return of around 7.79%.

Objective:
The expected goal in this research is to have cost and time efficiency in implementing infrastructure on the toll road project.

Materials and Methods:
This research is using a combination of case studies and statistical analysis; the case studies and the implementation of the M-PERT and VE on the object. Statistical analysis using simulation tools Relative Importance Index (RII) analysis based on research instruments to the success of the implementation of Manual Program Evaluation and Review Technique (M-PERT) and Value Engineering (VE) on toll road projects.

Conclusion:
The results of research with the analysis RII reveals that 10 important factors are affecting the performance of a project. The case study using the M-PERT method obtains a value of time accuracy of 98.87% of the real duration needed on site, while the VE method results in a revenue contribution outside of the toll income of 9.38% of the construction cost.
Hemorrhagic ulcerative uremic stomatitis: a case report
Authors: salha wahbi ben , moussaoui eya , jlassi karim , oualha lamia , douki nabiha 
Published: November 2021

Uremic stomatitis is a rare manifestation associated with longstanding
uremia in chronic renal failure patients. Its evolution is
favorable with earlier institution of renal replacement therapy. This
case shows that this condition should always be suspected by the
dentist when the context of advanced renal disease is present.
PENGARUH KONSENTRASI PAKLOBUTRAZOL PADA PERTUMBUHAN DAN PENAMPILAN TANAMAN SEDAP MALAM (Polyanthes tuberosa L.) DALAM POT
Authors: Rugayah Rugayah , Hendarto Kus , Ginting Yohannes C. , Ristiani Rina 
Published: November 2021

Tuberose (Polyanthus tuberosa L.) is a popular ornamental plant in Indonesia as cut flowers and sowing flowers. It can be used as potted flowers by making the flower stalks shorter. One way to get tuberose that have criteria as potted flowers is by administering growth inhibitors using Paclobutrazol. This research was conducted at the Greenhouse of the Horticultural Building, Faculty of Agriculture, University of Lampung in November to August 2017, aimed to determine the effect of the concentration of paclobutrazol on the growth and appearance of tuberose and to determine the best concentration of paclobutrazol in the appearance of potted tuberose. This study used a randomized block design (RCBD) with a single treatment with 6 levels of paclobutrazol concentration, namely 0, 75, 150, 225, 300, and 375 ppm with 3 replications. Homogeneity of variance was tested by Bartlett test and additivity was tested by Tukey test. Then, it was continued with the F test and with the Least Significant Difference test (LSD) at the 5% level. The results showed that administration of paclobutrazol was significantly affected pseudo stem circumference and all variables of generative growth except the length of the florets. The concentration of paclobutrazol up to 375 ppm has not obtained optimum results. Keywords: Concentration, growth, paclobutrazol, tuberose
PENGARUH PENYIMPANAN SAMPAI ENAM BULAN MENGGUNAKAN BUBUK DAN TANPA BUBUK LADA TERHADAP MUTU LIMABELAS LOT BENIH KEDELAI (Glycine max L.)
Authors: Kurniati Ayu , Agustiansyah Agustiansyah , Nurmiaty Yayuk , Ermawati Ermawati 
Published: November 2021

This study aims to determine the best seed quality from fifteen lots of soybean seeds that are stored for up to six months using pepper powder and without using pepper powder. The treatment was applied in a Completely Randomized Design (CRD) which was repeated three times. The combination of treatments derived from three varieties, namely Anjasmoro, Gerobogan, and Burangrang combined with 5 SP-36 fertilizer doses, namely 0, 100, 150, 200, and 250 kg / ha. The experiment consisted of two experiments. Experiment 1, the fifteen lots of seeds were stored without pepper powder. Experiment 2, the fifteen lots of seeds were ground with pepper in their storage. Storage at room temperature ranges from 28-30oC in the Seed and Plant Breeding Laboratory, Faculty of Agriculture, University of Lampung in October 2017 to April 2018 The results showed that the combination treatment of Burangrang varieties with SP-36 250 kg / ha fertilizer stored without pepper powder or pepper powder was able to maintain its higher quality compared to other treatment combinations after being stored for up to six months Key words: Fertilizer, pepper powder, soybean, storage, variety
EFEKTIVITAS FORMULASI BIOHERBISIDA EKSTRAK BUAH LERAK DENGAN PENAMBAHAN ADJUVAN TERHADAP PERKECAMBAHAN GULMA Ludwigia octovalvis
Authors: Pujisiswanto Hidayat , Sunyoto Sunyoto , Sriyani Nanik , Pratiwi Melinda Tri 
Published: November 2021

The abundance of weeds in cultivated land can directly inhibit competition of plants growth. Weed control using bioherbicides is one of eco-friendly alternative. This research aims to determine the bioherbicide formulation of lerak fruit extract with the addition of adjuvants which can inhibit the germination of Ludwigia octovalvis. The research was conducted at the Weed Laboratory of the Faculty of Agriculture, University of Lampung in December 2019 - March 2020. The researcher used Complete Randomized Design (CRD) with four replications. The research treatments consisted of lerak fruit extract + KAO adjuvant, lerak fruit extract + VCO, lerak fruit extract + Tween, pure lerak fruit extract, and control (aquades). The results showed that the application of 50% (500 g / l) lerak fruit extract with the addition of VCO, KAO, and Tween adjuvants at a concentration of 2% (20 ml/l) was able to inhibit weed germination Ludwigia octovalvis by 95%-100%. The application of lerak fruit extract with the addition of a 2% concentration of VCO adjuvant was the most effective in inhibiting weed germination Ludwigia octovalvis. Keywords : adjuvants, Bioherbicide, Sapindus rarak, Ludwigia octovalvis, weed
Pengaruh Dosis Pupuk NPK dan Jenis Pupuk Pelengkap terhadap Pertumbuhan dan Produksi Cabai (Capsicum annuum L.)
Authors: Hendarto Kus , Ginting Yohanes Cipta , Karyanto Agus , Amanda Virginia Chintya 
Published: November 2021

This study aims to determine the effect of NPK dosage, types of complementary fertilizers and their interactions on the growth and production of chilies pepper. This research was conducted in Sukabanjar Village, Gedong Tataan, Pesawaran Regency from July-December 2020. The experimental design used in this study was a two-factor randomized block design (RBD), namely the dose of NPK fertilizer and the type of complementary fertilizer (4 × 2) with 3 replications. Each plot consisted of 8 plants so that there were 192 plants. The first factor was NPK Mutiara fertilizer dose (16:16:16)(N) with N0:0 g/plant, N1:10 g/plant, N2:20 g/plant and N3:30 g/plant. The second factor is the type of complementary fertilizer (P) with P1 Plant Catalyst and P2 Gandasil D. Homogeneity of variance was tested by Bartlett test, additivity was tested by Tukey test. Then it was continued with analysist of variance and with the Least Significant Difference test (LSD) at the 5% level. Treatment of NPK fertilizer dosage significantly increases growth and yield. The interaction between the NPK dosage of 20g/plant and type of complementary fertilizers gave highest plant height (95.58 cm). The best combination was NPK dosage of 20 g/plant and Plant Catalyst fertilizer that gave highest yield (753,17 g/plant equivalent 15.06 ton/ha at population 20,000 plant/ha.Keywords : Chili pepper, complimentary fertilizer, growth, NPK, yield
Karakteristik Pertumbuhan Melada dan Lada Sambung
Authors: Anggraini Nova , Evizal Rusdi , Septiana Liska Mutiara 
Published: November 2021

Wild pepper of Piper colubrinum Link is used as rootstocks for grafted black pepper (Piper nigrum/Piper colubrinum) because its resistance to fungi that cause root rot disease. Grafted black pepper nurseries and plantations began to be developed by farmers in Lampung. This research aims to study the growth characteristics of wild pepper and grafted black pepper plants. The research was conducted in the field of wild pepper and grafted black pepper owned by farmers in Air Kubang Village, Air Naningan District, Tanggamus, Lampung, using survey method. Plant samples were determined randomly in the fields. The results showed that: (1) Wild pepper plants starts at the age of 1 year form plagiotropic branches with small diameters every 1-2 orthotropic branches, but slowly form orthotropic branches; (2) After the second pruning (of harvesting cuttings) 22% of the plants form orthotropic branches. The yield of pepper cuttings from the first to third harvests increased by 21-25% compared to the previous yield. In the third harvest, the production of cuttings reached 5066 cuttings (2 nodes) per 400 m2 land area or equivalent to 126,650 cuttings per ha of land harvested every 2 months; (3) At the age of 18 months, compared to non-grafted, grafted black pepper showed a greater greeness leaf index, larger stem diameter, larger plagiotropic branch diameter, higher number of orthotropic and plagiotropic branches, and 15.6% of grafted black pepper plants were flowering. Key words : Black pepper, cutting, flowering, growth, grafting, Piper colubrinum
Sea Prayer: An Illustrated Literary Narration on the Afflictions of Refugees
Authors: Nandi Srima 
Published: November 2021

Children have been the most sought-after artist, sculptors, creators, innovators, poets, builders, and are likely to practice many professions and become one. As curious learners from their toddler life, they try to grab any object that is around and make some sense out of them. For instance, playing on a heap of sand they construct their dream homes, getting hold of their dad’s stethoscope they try to feel the ‘lub dub’ beat on the chest of their parents; playing with the cooking vessels that they stealthily take it from their mother’s kitchen and play the role of a cook and chef by heating water on a toy gas stove etc. These little incidents in their life, as little ones, have given a giant leap for mankind in the field of discovery and inventions.
Many scientists like James Watt (watching the boiling kettle in his mother’s cottage), Archimedes (incident in his bathing tub), Isaac Newton (falling apple) and many other such scientists have invented something or the other, through observations and experiences. These inventions are taught to children in their science classes according to their syllabus that are graded by the education department and syllabus makers. This article will make an attempt to cater interest among students to get into the picturesque and fascinating world of children’s Nursery Rhymes to understand and learn many scientific and engineering concepts from it. Through the pictorial representations found in the nursery rhymes, many engineering concepts can be taught to children between the ages of six to fifteen. This can be seen as one of the innovative methods of revealing the great wonders of science through the Nursery Rhymes.
The mycobiome of the oral cavity in healthy dogs and dogs with periodontal disease
Authors: Niemiec Brook A. , Gawor Jerzy , Tang Shuiquan , Prem Aishani , Krumbeck Janina A. 
Published: November 2021

Abstract

OBJECTIVE
To investigate the mycobiome of the oral cavity in healthy dogs and dogs with various stages of periodontal disease.

ANIMALS
51 dogs without periodontal disease (n = 12) or with mild (10), moderate (19), or severe (10) periodontal disease.

PROCEDURES
The whole maxillary arcade of each dog was sampled with a sterile swab, and swabs were submitted for next-generation DNA sequencing targeting the internal transcribed spacer 2 region with a commercial sequencing platform.

RESULTS
Fungi were detected in all samples, with a total of 320 fungal species from 135 families detected in the data set. No single fungal species was found in all samples. The 3 most frequently found fungal species were Cladosporium sp (46/51 samples), Malassezia restricta (44/51 samples), and Malassezia arunalokei (36/51 samples). Certain fungi, specifically those of the family Didymellaceae, the family Irpicaceae, and the order Pleosporales, were significantly associated with different stages of periodontitis. Mycobial analysis indicated that Cladosporium sp could be considered part of the core oral cavity mycobiome.

CONCLUSIONS AND CLINICAL RELEVANCE
Results highlighted that fungi are present in the oral cavity of dogs and are characterized by substantial species diversity, with different fungal communities associated with various stages of periodontal disease. The next-generation DNA sequencing used in the present study revealed substantially more species of fungi than previous culture-based studies.