bluuebunny/crossref_metadata_2025_split huggingface dataset:
Klugee: Web-Based Application for Teaching Mathematics in English to Indonesian Elementary School Students
Authors: Amiroh Bebasari 
Published: November 2021

Despite the advancement of digital technology, there is no application specializing in teaching mathematics in English for Indonesian elementary school learners. During the pandemic, teachers need online teaching media to assist them when teaching mathematics. This article covers the project of teaching media creation for teaching Common Core mathematics to Indonesian elementary school students. The objectives of this project are creating web-based applications focusing to assist teachers to teach Mathematics in English for Indonesian Elementary students; and providing tools for the teachers in terms of material management such as curriculum and exercises; student management; and step-by-step guide during teaching in the classroom setting. Content and Language Integrated Learning (CLIL) is the teaching method supported by the teaching media. The results of the project are two web-based applications. The first application is the Learning Application which contains the mathematics teaching materials and student management. The second application is the Teaching Guide application, which contains the step-by-step-guide for teachers in CLIL classroom setting. The informal trials with 13 elementary students and 4 mathematics teachers as the participants showed positive results.
The Mediation Effect of Overall Brand Equity between Brand Superiority and Media Consumption Behaviours of Sport Team Consumers During COVID-19
Authors: Yağiz Kadir 
Published: November 2021

Background. During the COVID-19 pandemic, it is paramount to investigate how to influence professional sport team consumers’ behaviours towards media consumption, which is an indirect consumption of sports products with importance raised by the lockdown. The effect of brand superiority, one of the essential consumer judgments about the brands, on some behavioural intentions of sport team consumers was examined before; however, the role of brand superiority and overall brand equity on media consumption behaviours in pandemic conditions lacked empirical investigation. Therefore, this study aims to examine the relationship between brand superiority, overall brand equity and media consumption behaviours among professional sports teams’ consumers during the COVID-19 pandemic.
Methods. The participants of this quantitative study were 232 volunteer football (soccer) consumers who support a team in the Turkish Super Football League. The data was collected in 3 weeks using the online convenience sampling method. Confirmatory factor analysis (CFA) and structural equation modelling (SEM) were used in data analyses, and direct and indirect paths tested by the bootstrapping method.
Results. The results of the study showed that brand superiority did not have a direct effect on media consumption behaviours of sport team consumers. Besides, overall brand equity had a direct effect on media consumption behaviours and mediated the relationship between brand superiority and media consumption behaviours.
Conclusions. The evidence in this study indicates sport managers that the cognitive judgement of sport consumers, generally related to the more functional aspect of a sports product alone not an efficient way to directly influence sport team consumers toward media consumption behaviours even in COVID-19 pandemic. Brand equity, however, found to be an effective tool to address for directing sport team consumers’ behaviours toward media consumption in the extraordinary circumstance currently exist.
Keywords: branding, sports industry, spectator sports, professional sports teams, sports consumers.
Causal Association of Coffee Consumption and Total, Knee, Hip and Self-Reported Osteoarthritis: A Mendelian Randomization Study
Authors: Zhang Yangchang , Fan Jun , Chen Li , Xiong Yang , Wu Tingting , Shen Shisi , Wang Xu , Meng Xuchen , Lu Yanjun , Lei Xun 
Published: November 2021

BackgroundThe causal association between coffee consumption and the risk of OA is limited. This study was conducted to identify the potential causal effects of coffee consumption on total, knee, hip, and self-reported OA.MethodsGenome-wide association studies (GWAS) of OA were derived from the UK Biobank, comprising 50,508 participants of European ancestry (10,083 with cases and 40,425 controls), and genetic data for specific diagnosed knee OA (4462 cases and 17,885 controls), hip OA (12,625 cases and 50,898 controls), and self-reported OA (12,658 cases and 50,898 controls). Primary and secondary genetic instruments (11 SNPs and 8 SNPs) were selected as instrumental variants from GWAS among 375,833 and 91,462 participants. Two-sample Mendelian randomization (MR) analyses were performed to test the effects of the selected single nucleotide polymorphisms (SNPs) and the OA risk. The causal effects were primarily estimated using weighted median and inverse-variance weighted method with several sensitivity analyses.ResultsThe MR analyses suggested that genetically predicted 1% increase of coffee consumption was associated with an increased risk of overall OA (OR:1.009, 95% CI:1.003-1.016), knee OA (OR:1.023, 95% CI:1.009-1.038), self-reported OA (OR:1.007, 95% CI:1.003-1.011), but not hip OA (OR: 1.012, 95%CI:0.999-1.024) using primary genetic instruments. Similar results were found when using secondary genetic instruments that genetically predicted coffee consumption (cups/day). Additionally, the sensitivity analyses for leave-one-out methods supported a robust association between exposure traits and OA.ConclusionOur findings indicate that genetically predicted coffee consumption exerts a causal effect on total, knee, and self-reported OA risk, but not at the hip. Further research is required to unravel the role of coffee consumption in OA prevention.
A Novel Strategy Conjugating PD-L1 Polypeptide With Doxorubicin Alleviates Chemotherapeutic Resistance and Enhances Immune Response in Colon Cancer
Authors: Wang Maolin , Shu Xing-sheng , Li Meiqi , Zhang Yilin , Yao Youli , Huang Xiaoyan , Li Jianna , Wei Pengfei , He Zhendan , Lu Jun , Ying Ying 
Published: November 2021

BackgroundModifying the structure of anti-tumor chemotherapy drug is of significance to enhance the specificity and efficacy of drug-delivery. A novel proteolysis resistant PD-L1-targeted peptide (PPA1) has been reported to bind to PD-L1 and disrupt the PD-1/PD-L1 interaction, thus appearing as an outstanding tumor-targeting modification of synergistic drug conjugate for effective anti-tumor treatment. However, the combination regimen of coupling PD-L1 polypeptide with chemotherapeutic drug in tumoricidal treatment has not been reported thus far.MethodsWe developed a novel synergistic strategy by conjugating PPA1 to doxorubicin (DOX) with a pH sensitive linker that can trigger the release of DOX near acidic tumor tissues. The binding affinity of PPA1-DOX with PD-L1 and the acid-sensitive cleavage of PPA1-DOX were investigated. A mouse xenograft model of colon cancer was used to evaluate the biodistribution, cytotoxicity and anti-tumor activity of PPA1-DOX.ResultsPPA1-DOX construct showed high binding affinity with PD-L1 in vitro and specifically enriched within tumor when administered in vivo. PPA1-DOX exhibited a significantly lower toxicity and a remarkably higher antitumor activity in vivo, as compared with free PPA1, random polypeptide-DOX conjugate, DOX, or 5-FU, respectively. Moreover, increased infiltration of both CD4+ and CD8+ T cells was found in tumors from PPA1-DOX treated mice.ConclusionsWe describe here for the first time that the dual-functional conjugate PPA1-DOX, which consist of the PD-L1-targeted polypeptide that renders both the tumor-specific drug delivery and inhibitory PD-1/PD-L1 immune checkpoint inhibition, and a cytotoxic agent that is released and kills tumor cells once reaching tumor tissues, thus representing a promising therapeutic option for colon cancer with improved efficacy and reduced toxicity.
Endoscopic and Robotic Parotidectomy for the Treatment of Parotid Tumors: A Systematic Review and Meta-Analysis
Authors: Chen Shanwen , Zhao Mei , Wang Dong , Zhao Yi , Qiu Jianxin , Liu Yehai 
Published: November 2021

BackgroundThe goal of this review was to introduce endoscopic/robotic parotidectomy (EP/RP) and compare EP/RP against conventional parotidectomy (CP) regarding the intraoperative and postoperative parameters in the treatment of parotid tumors.MethodsA systematic literature search of medical databases (PubMed, Embase, and Cochrane Central Register of Controlled Trials) was performed from inception to November 2020 to generate relevant studies.ResultsA total of 13 eligible studies (572 patients) were included for systematic review, and 7 out of 13 comparable studies for the quantitative synthesis of outcomes. Patients who underwent EP were characterized by less intraoperative bleeding volume, shorter incision length, and higher satisfaction postoperatively (WMD, 95% CI, -42.80; - 58.23 to -27.37; p &lt; 0.01; WMD, 95% CI, -5.64; -7.88 to -3.39; p &lt; 0.01; SMD, 95% CI, 1.88; 1.46 to 2.31; p &lt; 0.01, respectively). However, operative time and risk of facial palsy exhibited no significant differences (WMD, 95% CI, -11.17; -26.71 to 4.34; p = 0.16; OR, 95% CI,0.71; 0.39 to 1.32; p = 0.28, respectively).ConclusionsOur findings suggest that the current evidence does not adequately support EP is equally safe and effective as CP. In certain selected cases, endoscopic technology has its unique advantages. For patients with strong cosmetic needs, endoscopic or robotic techniques may be an alternative through adequate preoperative evaluations.Systematic Review RegistrationInternational Prospective Register of Systematic Reviews, identifier CRD42020210299.
Mortality and Loss to Follow-Up Among HIV-Exposed Infants After Option B+ Guideline Implementation in Amhara Regional State Referral Hospitals, Ethiopia
Authors: Kassaw Mesfin Wudu , Abebe Ayele Mamo , Abate Biruk Beletew , Getu Mikiyas Amare , Kassie Ayelign Mengesha 
Published: November 2021

Background: Prevention of mother-to-child transmission of HIV program (PMTCT) is a comprehensive approach that aimed for the wellbeing of all HIV-infected women, to prevent new HIV infection among infants born to HIV-positive mothers, and providing management for HIV-positive women and infants. Nevertheless, there was considerably high attrition within the prevention of mother-to-child transmission programs that was merely because of loss to follow-up (LTFU) followed by mortality. In resource-limited countries, one-third of infected children die before 1 year, and more than half of them die before 2 years. The aim of this study was to assess the prevalence or incidence of mortality and LTFU among infants born from HIV-positive mothers in the Amhara regional state referral hospitals, Ethiopia.Methods: This study was conducted in five Amhara regional state referral hospitals' prevention of mother-to-child transmission departments. A simple random sampling technique with proportional allocation was used to assess the outcomes of 221 exposed infants. A retrospective cohort design was used in selecting the 221 exposed infants' document from the referral hospitals of the region, Amhara. The exposed infants' profiles were documented between January 1, 2014 and May 30, 2017.Results: This study described attritions (death and loss-to-follow-up) of exposed babies in PMTCT departments of Amhara regional state referral hospitals in Ethiopia. In this study, low LTFU with zero death was reported. Residence, immunization status of babies, and place of delivery were independent factors of LTFU.Conclusions: The cumulative incidence of mortality in this study was zero. This assured that the recommended option is substantial for the elimination of HIV-caused death in 2030 as per WHO plan. However, the cumulative incidence of LTFU was not zero.
Just Do It: High Intensity Physical Activity Preserves Mental and Physical Health in Elite and Non-elite Athletes During COVID-19
Authors: Casali Nicole , Cerea Silvia , Moro Tatiana , Paoli Antonio , Ghisi Marta 
Published: November 2021

Background: The COVID-19 pandemic forced most Italian athletes to cease their regular training activities, with possible consequences on both mental and physical health. The present study aimed at assessing changes in Physical Activity (PA) from pre- to lockdown, and examining the relationships among lockdown PA, quality of life (mental and physical health), motivation to exercise, psychological distress, intolerance of uncertainty, and body dissatisfaction.Methods: A total of 204 athletes of different sports (91 elite; 110 females; mean age = 22.55, SD = 5.76) answered an online survey investigating demographics, sport-related questions, PA (IPAQ-S), quality of life (SF-12), and psychological variables (BREQ-2, DASS-21, IUS-R, and EDI-3-Body dissatisfaction subscale).Results: Both elite and non-elite athletes significantly reduced their PA intensity and volume (p &lt; 0.001). Elite athletes did not differ from non-elite in terms of total PA intensity and hours of training during lockdown (p &gt; 0.05). Elite and individual athletes showed higher intrinsic motivation to exercise compared to non-elite and team sports (p &lt; 0.01). Female athletes displayed higher distress, worse mental health, and higher body dissatisfaction than males (p &lt; 0.05). Mediation models showed that vigorous PA positively affected both mental (p &lt; 0.05) and physical (p &lt; 0.001) health during lockdown, independently of distress and intolerance of uncertainty.Conclusion: The COVID-19 lockdown was taxing for athletes, particularly professionals; those who were able to practice PA at high intensity during lockdown reported better mental and physical health.
Geospatial Analysis of Food Deserts and Their Impact on Health Outcomes in Children with Cystic Fibrosis
Authors: Corbera-Hincapie Montserrat A. , Kurland Kristen S. , Hincapie Mark R. , Fabio Anthony , Weiner Daniel J. , Kim Sandra C. , Kazmerski Traci M. 
Published: November 2021

Food insecurity (FI) is defined as “the limited or uncertain access to adequate food.” One root cause of FI is living in a food desert. FI rates among people with cystic fibrosis (CF) are higher than the general United States (US) population. There is limited data on the association between food deserts and CF health outcomes. We conducted a retrospective review of people with CF under 18 years of age at a single pediatric CF center from January to December 2019 using demographic information and CF health parameters. Using a Geographic Information System, we conducted a spatial overlay analysis at the census tract level using the 2015 Food Access Research Atlas to assess the association between food deserts and CF health outcomes. We used multivariate logistic regression analysis and adjusted for clinical covariates and demographic covariates, using the Child Opportunity Index (COI) to calculate odds ratios (OR) with confidence intervals (CI) for each health outcome. People with CF living in food deserts and the surrounding regions had lower body mass index/weight-for-length (OR 3.18, 95% CI: 1.01, 9.40, p ≤ 0.05 (food desert); OR 4.41, 95% CI: 1.60, 12.14, p ≤ 0.05 (600 ft buffer zone); OR 2.83, 95% CI: 1.18, 6.76, p ≤ 0.05 (1200 ft buffer zone)). Food deserts and their surrounding regions impact pediatric CF outcomes independent of COI. Providers should routinely screen for FI and proximity to food deserts. Interventions are essential to increase access to healthy and affordable food.
teoría del todo del “Modelo universal de aprendizaje por comprensión integral significativa”
Authors: Aráuz Rodríguez Mario Roberto , Aráuz Chávez Andrea 
Published: November 2021

La investigación tuvo como objetivo optimizar el rendimiento académico y la comprensión lectora estudiantil y científica, con base en la aplicación de los adelantos científicos en diferentes ramas del Modelo universal de aprendizaje por comprensión integral significativa. Metodológicamente fue una investigación bibliográfica multicientífica, enfoque interpretativo, diseño funcional y aplicacióndecampoparasucomprobación y verificación. Los resultados develaron la optimización del rendimiento estudiantil y la comprensión lectora científica por el uso de dos condicionantes: 1. Un proceso de aprendizaje fundamentado en cibernética, psicopedagogía, informática, desarrollo del pensamiento, neurología electro química, principio macro – micro, metodologías educativas presentadas en orden cronológico según su aparición en la historia de la humanidad, y 2. La aplicación de una técnica de comprensión lectora en unaconstruccióny comprensión de nivel superior de conocimiento. Se concluyó que no hay aprendizaje óptimo si no existe la progresión y secuencialidad del proceso de aprendizaje y la aplicación de la técnica de comprensión.
Interculturalidad en el Desarrollo de la Identidad Nacional en estudiantes del Colegio Emblemático Nº 56001 “Mateo Pumacahua”, Sicuani-Cusco
Authors: Araoz Enriquez Clotilde , Blanco Ayala Luis Fernando , Obregón Alzamora Norka Inés , Ruiz Conejo Ada Lucía Gallegos 
Published: November 2021

El presente artículo contribuye al análisis e interpretación de la interculturalidad y la identidad nacional en estudiantes para reflexionar sobre las políticas educativas. El objetivo principal es determinar la influencia entre las variables. La investigación es cuantitativa. La muestra se determinó por muestreo aleatorio simple, a quienes se aplicó la fórmula para determinar el tamaño de la muestra 51 profesores y 217 estudiantes. Se diseñaron dos instrumentos de recopilación de datos y para su aplicación se sometieron a pruebas de confiabilidad estadística para ello se utilizó el procedimiento estadístico: coeficiente de Alfa de Cronbach. Los resultados demuestran que los aspectos interculturales aplicados por los maestros durante la enseñanza, son buenos y promueven el desarrollo de la Identidad Nacional de los estudiantes. Concluimos que la Interculturalidad utilizada por los maestros influye significativamente en el desarrollo de la Identidad Nacional en estudiantes del Colegio Emblemático nº 56001 “Mateo Pumacahua”, Sicuani–Cusco.
ANALISIS HUKUM TERHADAP UPAYA PERLINDUNGAN DAN PEMBERDAYAAN NELAYAN KECIL DAN PEMBUDI DAYA IKAN
Authors: Hairun Mohammad Ismail 
Published: November 2021

Most fishermen and fish breeders live in poverty, are poorly educated and live in an atmosphere of business uncertainty. As part of citizens, they are constitutionally entitled to the protection and empowerment of the state. Therefore, the Republic of Indonesia Law No. 7 of 2016 concerning the Protection and Empowerment of Fishermen, Fish Farmers, and Salt Farmers was born. Two problem statements are raised, namely first; Legis ratio of protection and empowerment of fishermen, and secondly; a form of protection and empowerment of fishers and fish breedersThe research method used is a normative juridical research method because it uses primary and secondary legal materials with a qualitative analysis approach.Based on the results of the study can be concluded first; Legis ratio of protection and empowerment of fishermen and fish cultivators because fishermen and fish breeders are generally categorized as poor, low-educated, and powerless. As part of citizens who are entitled to fair legal recognition, guarantee, protection and certainty, and equal treatment before the law. Philosophically protect fishermen and fish breeders in conducting their business so that they are free or avoiding various problems and subsequently increase capacity in various aspects that benefit them.Both forms of protection for fishermen and fish farmers in the form of providing infrastructure and means of production of business activities, in the form of fishing gear, ships and/or ports, land and water ponds, and irrigation channels, provide guarantees of business certainty, guarantees of risk of catching and cultivating fish and elimination of high-cost economic practices. While the empowerment of fishermen and fish farmers is done by increasing the capacity of fishermen and fish farmers through education and training, fostering a spirit of self-sufficiency through counseling and mentoring, providing opportunities and opportunities for marketing, capital, increasing human resources, providing financing and capital facilities. Keywords; Protection, Empowerment, Fishermen and Fish breeders
BANTUAN HUKUM TERHADAP TERSANGKA YANG DIANCAM PIDANA LIMA TAHUN ATAU LEBIH DALAM PROSES PENYIDIKAN
Authors: Sunaryo Sunaryo 
Published: November 2021

Abstract Sunaryo. 2019. Legal Assistance to Suspects who are subject to a sentence of five years or more in The Investigation Process. Under supervised by Dr. Syafruddin, S.H., M.Hum, Dr. Ilham Agang, S.H., M.H This research background was based on the law enforcement of criminal law in Indonesia where the appreciation of human rights is often ignored by investigators to the suspect by doing acts of violence both psychological and physical violence through persecution. This occurred because suspects do not have legal assistance in process investigation. Based on Criminal Code Procedures (KUHAP) guarantees the right of suspects who threatened with a sentence of five years or more must be accompanied by his/her lawyer at every level of examination as stipulated in Article 114 KUHAP in section Article 56, verse (1). The research design of this research was normative law. The statute approach and conceptual approach were used in analyzing research data. Research data were primary; written law product, and secondary; law literature and specific literature and other relevant research sources. The results showed that the fulfillment of legal assistance to the suspects, who were threatened with a sentence of five years or more, in the investigation process was necessary needed to protect their rights and avoid acts of arrogance, arbitrariness, physical acts and psychological violence. However, if the investigators do not fulfill this matter, the lawsuits or demands of the public prosecutor cannot be accepted, so the case file is returned and asked for reinvestigation is carried out in accordance with the Criminal Procedure Code. The investigators should be punished because of their negligence. This research recommends that investigators should carry out the process investigations adhere to the Criminal Procedure Code by providing legal assistance to the suspect and if investigators commit negligence in carrying out investigations can be prosecuted with the ethics code of the National Police based on the law criminal procedure. Keywords: Legal assistance, Sanctions, and suspect's rights
Gênero Arcobacter e Saúde Pública: revisão sobre sua importância na saúde humana, principais vias de transmissão e patogenicidade
Authors: Moreira Lauren Machado , Silva Júlia Rosin da , Silveira Débora Rodrigues , Timm Cláudio Dias 
Published: November 2021

É apresentada uma revisão de literatura sobre o gênero Arcobacter, tratando da sua ocorrência determinando doença em humanos, da sua presença no meio ambiente e em alimentos de origem animal contaminados, bem como dos seus prováveis fatores de patogenicidade. Estes microrganismos estão dispersos no meio ambiente, sendo comumente encontrados em animais de produção e produtos de origem animal. Já foram descritos surtos decorrentes da infecção humana a partir do consumo de carne de frango, suína e leite contaminados. Este agente, além de possuir fatores de adesão e invasão para colonizar o trato gastrintestinal, produz citotoxinas que induzem o organismo do hospedeiro à resposta inflamatória.