bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reward Dysfunction in General and Specific Psychopathology in Children and Adults
Authors: Saxena Ankita , Hartman Catharina A. , Blatt Steven D. , Fremont Wanda P. , Glatt Stephen J. , Faraone Stephen V. , Zhang-James Yanli 
Published: October 2021

AbstractBackgroundReward dysfunction has been implicated in many psychiatric disorders such as attention-deficit/hyperactivity disorders, depression, and substance use disorders. However, psychiatric comorbidities are common, and the specificity of reward dysfunction to individual psychopathologies is unknown. The objective of this study was to evaluate the association between reward functioning and specific or general psychopathologies.Methods1044 adults and their 1215 children (ages 6-12) completed various measures of the Positive Valence System domain from the Research Domain Criteria (RDoC), which included the Delayed and Probability Discounting Tasks, Energy Expenditure for Reward Task, and Iowa Gambling Task. Children also completed the Experienced Pleasure Scale for children, while adults completed the Temporal Experience of Pleasure Scale and the Behavioral Activation System tasks. Psychopathology was assessed using the Child Behavior Checklist (CBCL) for children and the Adult Self Report (ASR) for parents.ResultsOne general factor identified via principal factors factor analysis explained the majority of variance in psychopathology in both groups. Reward measures in both adults and children were significantly associated with general psychopathology as well as most specific psychopathologies. Some associations between reward and psychopathology did not hold following removal of general psychopathology; nonetheless, certain reward constructs were uniquely associated with specific disorder problems but not general psychopathology.ConclusionDisorder problem specific associations with reward functioning can be identified after removal of comorbidity. General propensity toward psychopathology is significantly but not uniquely correlated with reward dysfunction. Altogether, this may have broader implications for future study of the role of reward in disease pathogenesis.
Combining Tumor Segmentation Masks with PET/CT Images and Clinical Data in a Deep Learning Framework for Improved Prognostic Prediction in Head and Neck Squamous Cell Carcinoma
Authors: Wahid Kareem A. , He Renjie , Dede Cem , Mohamed Abdallah , Abdelaal Moamen Abobakr , van Dijk Lisanne V. , Fuller Clifton D. , Naser Mohamed A. 
Published: October 2021

AbstractPET/CT images provide a rich data source for clinical prediction models in head and neck squamous cell carcinoma (HNSCC). Deep learning models often use images in an end-to-end fashion with clinical data or no additional input for predictions. However, in the context of HNSCC, the tumor region of interest may be an informative prior in the generation of improved prediction performance. In this study, we utilize a deep learning framework based on a DenseNet architecture to combine PET images, CT images, primary tumor segmentation masks, and clinical data as separate channels to predict progression-free survival (PFS) in days for HNSCC patients. Through internal validation (10-fold cross-validation) based on a large set of training data provided by the 2021 HECKTOR Challenge, we achieve a mean C-index of 0.855 ± 0.060 and 0.650 ± 0.074 when observed events are and are not included in the C-index calculation, respectively. Ensemble approaches applied to cross-validation folds yield C-index values up to 0.698 in the independent test set (external validation). Importantly, the value of the added segmentation mask is underscored in both internal and external validation by an improvement of the C-index when compared to models that do not utilize the segmentation mask. These promising results highlight the utility of including segmentation masks as additional input channels in deep learning pipelines for clinical outcome prediction in HNSCC.
Psychometric Properties of the ASEBA Child Behaviour Checklist and Youth Self-Report in Sub-Saharan Africa: A Systematic Review
Authors: Zieff Michal R. , Fourie Claire , Hoogenhout Michelle , Donald Kirsten A. 
Published: October 2021

AbstractObjectiveBehavioural screening tools may be used to identify at-risk children in resource-limited settings in sub-Saharan Africa. The ASEBA forms (Child Behaviour Checklist and Youth Self-Report) are frequently translated and adapted for use in sub-Saharan African populations, but little is known about their measurement properties in these contexts.MethodsWe conducted a systematic review of all published journal articles that used the ASEBA forms with sub-Saharan African samples. We evaluated the reported psychometric properties, as well as the methodological quality of the psychometric evaluations, using COSMIN (COnsensus-based Standards for the selection of health Measurement INstruments) guidelines.ResultsFifty-eight studies reported measurement properties of the ASEBA forms. Most studies came from Southern (n = 29, 50%) or East African (n = 25, 43%) countries. Forty-nine studies (84%) used translated versions of the tool, but details regarding the translation process, if available, were often sparse. Most studies (n = 47, 81%) only reported internal consistency (using coefficient alpha) for one or more subscales. The methodological quality of the psychometric evaluations ranged from ‘very good’ to ‘inadequate’ across all measurement properties, except for internal consistency.ConclusionThere is limited good quality psychometric evidence available for the ASEBA forms in sub-Saharan Africa. We recommend (i) implementing a standardised procedure for conducting and reporting translation processes, and (ii) conducting more comprehensive psychometric evaluations of the translated versions of the tools.
Factors affecting use of speech testing in adult audiology
Authors: Parmar Bhavisha J , Rajasingam Saima L , Bizley Jennifer K , Vickers Deborah A 
Published: October 2021

ABSTRACTObjectiveTo investigate the factors affecting the use speech testing in adult audiology servicesDesignA mixed-methods cross-sectional questionnaire studyStudy SampleA UK sample (n=306) of hearing healthcare professionals (HHPs) from the public (64%) and private sector (36%) completed the surveyResultsIn the UK, speech testing practice varied significantly between health sector. Speech testing was carried out during the audiology assessment by 68% of private sector HHPs and 5% of those from the public sector. During the hearing aid intervention stage speech testing was carried out by 40% and 8% of HHPs from the private and public sector, respectively. Recognised benefits of speech testing included: 1) providing patients with relatable assessment information, 2) guiding hearing aid fitting, 3) supporting a diagnostic test battery. A lack of clinical time was a key barrier to uptake.ConclusionUse of speech testing varies in adult audiology. Results from the present study found the percentage of UK HHPs making use of speech tests was low compared to other countries. HHPs recognised different benefits of speech testing in audiology practice but the barriers limiting uptake were often driven by factors derived from decision makers rather than clinical rationale. Privately funded HHPs used speech tests more frequently than those working in the public sector where time and resources are under greater pressure and governed by guidance that does not include a recommendation for speech testing. Therefore, the inclusion of speech testing in national clinical guidelines could increase the consistency of use.
Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine
Authors: Peng Kah-Whye , Carey Timothy , Lech Patrycja , Vandergaast Rianna , Muñoz-Alía Miguel Á. , Packiriswamy Nandakumar , Gnanadurai Clement , Krotova Karina , Tesfay Mulu , Ziegler Christopher , Haselton Michelle , Sevola Kara , Lathrum Chase , Reiter Samantha , Narjari Riya , Balakrishnan Baskar , Suksanpaisan Lukkana , Sakuma Toshie , Recker Jordan , Zhang Lianwen , Waniger Scott , Russell Luke , Petro Christopher D. , Kyratsous Christos A. , Baum Alina , Janecek Jody L. , Lee Rachael M. , Ramachandran Sabarinathan , Graham Melanie L. , Russell Stephen J. 
Published: October 2021

AbstractAn orally active vaccine capable of boosting SARS-CoV-2 immune responses in previously infected or vaccinated individuals would help efforts to achieve and sustain herd immunity. Unlike mRNA-loaded lipid nanoparticles and recombinant replication-defective adenoviruses, replicating vesicular stomatitis viruses with SARS-CoV-2 spike glycoproteins (VSV-SARS2) were poorly immunogenic after intramuscular administration in clinical trials. Here, by G protein trans-complementation, we generated VSV-SARS2(+G) virions with expanded target cell tropism. Compared to parental VSV-SARS2, G-supplemented viruses were orally active in virus-naive and vaccine-primed cynomolgus macaques, powerfully boosting SARS-CoV-2 neutralizing antibody titers. Clinical testing of this oral VSV-SARS2(+G) vaccine is planned.
A method for quantifyingPhytophthoraoospore viability using fluorescent dyes and automated image analysis
Authors: Fairhurst Michael J. , Vink Jochem N.A. , Deslippe Julie R. , Gerth Monica L. 
Published: October 2021

AbstractPhytophthoraare eukaryotic microbes that cause disease in a wide range of agriculturally and ecologically important plants. During thePhytophthoradisease cycle, thick-walled oospores can be produced via sexual reproduction. These resting spores can survive in the soil for several years in the absence of a host plant, thus providing a long-term inoculum for disease. The ability to quantitatively evaluate oospore viability is an important part of many phytopathology studies. Here, we tested six fluorescent viability dyes for their ability to differentially stainPhytophthora agathidicidaoospores: SYTO 9, FUN-1, fluorescein diacetate (FDA), 5-carboxyfluorescein diacetate (CFDA), propidium iodide, and TOTO-3 iodide. Each dye was first tested individually with untreated or heat-treated oospores as proxies for viable and non-viable oospores, respectively. SYTO9, FUN-1, CFDA and propidium iodide stained untreated and heat-treated oospores indiscriminately. In contrast, FDA (a green-fluorescent viable cell stain) and TOTO-3 (a red-fluorescent non-viable cell stain) differentially stained untreated or heat-treated oospores with no cross-fluorescence. We then tested the efficacy of dual viability staining and in conjunction with a pipeline for automated image analysis. To validate the method, untreated and heat-treated oospores were mixed at specific ratios, dual-stained, and analyzed using the pipeline. Linear regression of the resulting data showed a clear correlation between the expected and measured oospore ratios (dy/dx=0.95,R2=0.88). Overall, the combination of dual-fluorescence staining and automated image analysis provides a high-throughput method for quantitatively assessing oospore viability and therefore can facilitate further studies on this key part of thePhytophthoradisease cycle.
Aerosolization of Mycobacterium tuberculosis by tidal breathing
Authors: Dinkele Ryan , Gessner Sophia , McKerry Andrea , Leonard Bryan , Leukes Juane , Seldon Ronnett , Warner Digby F. , Wood Robin 
Published: October 2021

AbstractRationaleInterrupting tuberculosis (TB) transmission requires an improved understanding of how – and when – the causative organism, Mycobacterium tuberculosis (Mtb), is aerosolized. Although Cough is commonly assumed to be the dominant source of Mtb aerosols, recent evidence of Cough-independent Mtb release implies the contribution of alternative mechanisms.ObjectiveTo compare the aerosolization of Mtb and particulate matter from GeneXpert-positive patients during three separate respiratory manoeuvres: Tidal Breathing (TiBr), Forced Vital Capacity (FVC), and Cough.MethodologyBioaerosol sampling and Mtb detection were combined with real-time assessments of CO2 production and particle counts from 39 confirmed TB patients.Measurements and Main ResultsTiBr and FVC produced comparable numbers of particles, with Cough producing >4-fold more. For all manoeuvres, the proportions of particles detected across size categories from 0.5 – 5 μm were similar, with minor differences observed only in particles between 1.5 – 2 μm (p = 0.014) and >5 μm (p = 0.020). Viable Mtb bacilli were detected in 66%, 70%, and 65% of TiBr, FVC, and Cough samples, respectively. Notably, while Cough produced 3-fold more Mtb than TiBr, the relative infrequency of coughing compared to breathing implies that TiBr likely contributes >90% of the daily aerosolised Mtb across a range of Cough frequencies.ConclusionsOur results suggest that, while Cough increases particle aerosolization compared to TiBr, this is not associated with increased Mtb aerosolization. Instead, TiBr produces more Mtb per particle than Cough. Assuming the number of viable Mtb organisms detected provides a proxy measure of patient infectiousness, these observations imply a significant contribution of TiBr to TB transmission.
Alone Again: Altered Activation in the Observation Execution System during Synchronization in High Loneliness Individuals
Authors: Saporta Nira , Scheele Dirk , Lieberz Jana , Nevat Michael , Kanterman Alisa , Hurlemann René , Shamay-Tsoory Simone G. 
Published: October 2021

1AbstractLonely people evaluate social exchanges negatively and display difficulties in interactions. Interpersonal synchronization is crucial for achieving positive interactions, promoting affinity, closeness, and satisfaction. However, little is known about lonely individuals’ ability to synchronize and about their brain activity while synchronizing. Following the screening of 303 participants we recruited 32 low and 32 high loneliness participants. They were scanned while engaged in movement synchronization, using a novel dyadic interaction paradigm. Results showed that high loneliness individuals exhibited a reduced ability to adapt their movement to their partner’s movement. Intriguingly, during movement adaptation periods, high loneliness individuals showed increased activation in the observation-execution (OE) system, specifically in the inferior frontal gyrus and the inferior parietal lobule. They did not show increased activation in the dorsomedial prefrontal cortex, which in the context of synchronization was suggested to be related to gap-monitoring. Based on these findings, we propose a model according to which lonely people may require stronger activation of their OE system for alignment, to compensate for some deficiency in their synchronization ability. Despite this hyper-activation, they still suffer from reduced synchronization capacity. Consequently, synchronization may be a relevant intervention area for the amelioration of chronic loneliness.
Strip1 regulates retinal ganglion cell survival by suppressing Jun-mediated apoptosis to promote retinal neural circuit formation
Authors: Ahmed Mai , Kojima Yutaka , Masai Ichiro 
Published: October 2021

AbstractIn the vertebrate retina, an interplay between retinal ganglion cells (RGCs), amacrine, and bipolar cells establishes a synaptic layer called the inner plexiform layer (IPL). This circuit conveys signals from photoreceptors to visual centers in the brain. However, the molecular mechanisms involved in its development remain poorly understood. Striatin-interacting protein 1 (Strip1) is a core component of the STRIPAK complex, and it has shown emerging roles in embryonic morphogenesis. Here, we uncover the importance of Strip1 in inner retina development. Using zebrafish, we show that loss of Strip1 causes defects in IPL formation. Instrip1mutants, RGCs undergo dramatic cell death shortly after birth. Amacrine and bipolar cells subsequently invade the degenerating RGC layer, leading to a disorganized IPL. Mechanistically, zebrafish Strip1 interacts with its STRIPAK partner, Striatin3, and both show overlapping functions in RGC survival. Furthermore, loss of Strip1 or Striatin 3, leads to activation of the pro-apoptotic marker, Jun, within RGCs, and Jun knockdown rescues RGC survival instrip1mutants. In addition to its function in RGC maintenance, Strip1 is required for RGC dendritic patterning, which likely contributes to proper IPL formation. Taken together, we propose that a series of Strip1-mediated regulatory events coordinates inner retinal circuit formation by maintaining RGCs during development, which ensures proper positioning and neurite patterning of inner retinal neurons.
Bees can be trained to identify SARS-CoV-2 infected samples
Authors: Kontos Evangelos , Samimi Aria , Hakze-van der Honing Renate W. , Priem Jan , Avarguès-Weber Aurore , Haverkamp Alexander , Dicke Marcel , Gonzales Jose L , van der Poel Wim H.M. 
Published: October 2021

AbstractThe COVID-19 pandemic has illustrated the need for the development of fast and reliable testing methods for novel, zoonotic, viral diseases in both humans and animals. Pathologies lead to detectable changes in the Volatile Organic Compound (VOC) profile of animals, which can be monitored, thus allowing the development of a rapid VOC-based test. In the current study, we successfully trained honeybees (Apis mellifera) to identify SARS-CoV-2 infected minks (Neovison vison) thanks to Pavlovian conditioning protocols. The bees can be quickly conditioned to respond specifically to infected mink’s odours and could therefore be part of a wider SARS-CoV-2 diagnostic system. We tested two different training protocols to evaluate their performance in terms of learning rate, accuracy and memory retention. We designed a non-invasive rapid test in which multiple bees are tested in parallel on the same samples. This provided reliable results regarding a subject’s health status. Using the data from the training experiments, we simulated a diagnostic evaluation trial to predict the potential efficacy of our diagnostic test, which yielded a diagnostic sensitivity of 92% and specificity of 86%. We suggest that a honeybee-based diagnostics can offer a reliable and rapid test that provides a readily available, low-input addition to the currently available testing methods. A honeybee-based diagnostic test might be particularly relevant for remote and developing communities that lack the resources and infrastructure required for mainstream testing methods.
James March: a postmodern perspective on organization without management theory
Authors: Lambert Gilles 
Published: October 2021

Purpose
In this paper, the authors look back at James March’s main contributions to the evolution of organizations and their decision-making. No other author in management science has been quoted as much. Yet, his view on these issues is often far removed from the dominant academic representations. This paper aims to evaluate the trace left by March for the future. His teachings remain of the utmost importance for both practitioners and academics in charge of modeling the real functioning of the organizations.

Design/methodology/approach
In this paper, the authors look back at James March’s main contributions to the evolution of organizations and their decision-making.

Findings
On the basis of an in-depth analysis of his study, the authors discuss the main concepts to which he has dedicated his life as a researcher. Whether it is for innovation and the process of exploration associated with it or for the ambiguity that persists in learning cycles, March always shows us the ambivalence of the concepts. The strength of March’s study is to encourage us to remain cautious in the diagnoses for the development of the companies by not venerating too strongly the notions seen exclusively as virtuous, such as innovation or by not too quickly condemning situations perceived as harmful, such as ambiguity. It is, therefore, subjective and unpredictable, making the idea of a unified theory of management inoperative (Joullié, 2018). March’s way of thinking is deeply postmodern in the sense of Foucault (1961), who saw the world as a representation.

Research limitations/implications
For this kind of paper based on a James March study’s survey, the main limitation is the variety of research methodology mobilized. Empirical confirmation sometimes is missing or is too short. The study remains essentially speculative as to its influence on future research. Some concepts, such as the concept of effectuation, which is a direct extension of March’s study, deserve to be tested empirically and theoretically in greater depth to assess their robustness.

Practical implications
All managerial implications are concerned with organizational change. His teachings remain of the utmost importance for both practitioners and academics in charge of modeling the real functioning of the organizations.

Social implications
Providing a guideline concerning research in the management of organizations. A better understanding of the real functioning of how decisions happen in companies, how they change in the real world.

Originality/value
The authors show that, contrary to the great paradigms of management sciences (Burrell and Morgan, 1979) developed since Taylor’s founding study, which remains performative in essence, March’s study initiates a viscerally postmodern vision of the organization. The authors believe that his contributions are essential because they are not based on a normative attempt to propose a universal theory but provide a compass that is essential to understanding how the organization study.
Do sponsors and democratic government influence the flipping activity of Pakistan IPO? Evidence from developing market
Authors: Anwar Ayesha , Mohd-Rashid Rasidah , Che Yahya Norliza , Ong Chui Zi 
Published: October 2021

Purpose
This study aims to examine the impact of sponsors and democratic government on the flipping activity of initial public offerings (IPOs).

Design/methodology/approach
Based on the sample of 95 IPOs listed on the Pakistan Stock Exchange between January 2000 and December 2019, this study used multiple cross-sectional regression to examine the relationship between sponsors and democratic government on flipping activity.

Findings
The findings indicate a significant negative association between sponsors and the flipping activity of IPOs. Sponsor(s) signal quality by trying to share accurate information about company values. As a result, the confidence of rational investors in the company’s future prospectus increases and they hold their shares for future gains, which reduces the flipping activity. Also, democratic government, along with sponsors' participation, provides investors with liquidity immediately after listing.

Practical limitations/implications
The findings of this study have implications for investors as they may assist them make informed decisions about whether or not to invest in an IPO with high sponsor(s) ownership. In addition, issuers should consider the disclosure of sponsor information(s) as such information may directly affect the first day’s trading volumes.

Originality/value
To the best of the authors’ knowledge, this is the first research study that explores the correlation between sponsors and democratic government and flipping activity of IPO. This study is important for investors and issuers.