bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-cell analysis identified key macrophage subpopulations associated with atherosclerosis
Authors: Zhao Zhenzhen , Qin Yuelong , Wu Rui , Li Wenwu , Dong Yujiang 
Published: December 2024

Abstract

Background
Atherosclerosis is a lipid-driven inflammatory disease characterized by plaque formation in major arteries. These plaques contain lipid-rich macrophages that accumulate through monocyte recruitment, local macrophage differentiation, and proliferation.

Objective
We identify the macrophage subsets that are closely related to atherosclerosis and reveal the key pathways in the progression of atherosclerotic disease.

Materials and methods
In this study, we characterize the single-cell landscape of atherosclerosis, identifying macrophage subsets closely related to the disease and revealing key pathways in its progression. Using analytical methods like CytoTRACE, Monocle2, Slingshot, and CellChat, we study macrophage differentiation and infer cell trajectory.

Results
The 8,417 macrophages were divided into six subtypes, macrophages: C0 C1QC+ macrophages, C1 SPP1+ macrophages, C2 FCN1+ macrophages, C3 IGKC+ macrophages, C4 FCER1A+ macrophages, C5CALD1+ macrophages. The results of gene set enrichment analysis, Monocle2, and Slingshot suggest that C2 FCN1+ macrophages may play an important role in the progression of atherosclerosis. C2 FCN1+ macrophages interact with endothelial cells via CCL, CXCL, APP, and other pathways to regulate the progression of atherosclerosis.

Conclusion
We identify a key macrophage subgroup (C2 FCN1+ macrophages) associated with atherosclerosis, which interacts with endothelial cells via CCL, CXCL, APP, and other pathways to regulate disease progression.
Immune cells in Alzheimer’s disease: insights into pathogenesis and potential therapeutic targets
Authors: Fu Xiaofeng , Cai Huimin , Quan Shuiyue , Ren Ziye , Xu Yinghao , Jia Longfei 
Published: December 2024

Abstract
Alzheimer’s disease (AD) is a chronic neurodegenerative disorder for which there are currently no effective treatment options. Increasing evidence suggests that AD is a systemic disease closely associated with the immune system, not merely a central nervous system (CNS) disorder. Immune cells play crucial roles in the onset and progression of AD. Microglia and astrocytes are the primary inflammatory cells in the brain that can sensitively detect changes in the internal environment and transform into different phenotypes to exert differing effects at various stages of AD. Peripheral immune cells, such as T cells, B cells, monocytes/macrophages, and neutrophils can also be recruited to the CNS to mediate the inflammatory response in AD. As such, investigating the role of immune cells in AD is particularly important for elucidating its specific pathogenesis. This review primarily discusses the roles of central innate immune cells, peripheral immune cells, and the interactions between central and peripheral immune cells in the development of neuroinflammation in AD. Furthermore, we listed clinical trials targeting AD-associated neuroinflammation, which may represent a promising direction for developing effective treatments for AD in the future.
Effect of friction stir spot welding parameters on the shear fracture load of AA8011/structural steel for automotive applications
Authors: Nelson Esther Edwin Paul , Sambath Srinivasan , Samraj Ravi , Chinnasamy Rajendran 
Published: December 2024

Abstract
AA8011 and mild steel are the most suitable candidates for several structural applications due to their unique properties. However, joining these two materials with fusion welding poses challenges for manufacturing engineers. As a result, it often leads to issues such as hot cracking, porosity, and alloy segregation due to incompatibilities in metallurgical factors. An alternative method, friction stir welding, is used to join these materials. While lap joint configuration is common in many sectors for joining different thicknesses, traditionally it has been performed using rivets, bolts, and fusion welding processes. In this investigation, friction stir spot welding is employed to eliminate the need for rivets. To analyse the influence of major process parameters on shear fracture load, a systematic analysis is conducted. From the experimental results, it is detected that the joint welded with a tool rotational speed of 1,000 rpm, plunge rate of 4 mm.min−1, dwell time of 5 s, and a tool shoulder to pin diameter ratio of 3.0 exhibited peak load carrying capabilities of 9.46 kN. This can be attributed to the optimum levels of hook width, hook height and balanced material flow.
Energy efficiency in materials testing by reactive power part 2: resonance method in fatigue testing
Authors: Findeisen Dietmar , Schröpfer Dirk 
Published: December 2024

Abstract
Reactive power is related to the type of power that does not consume energy but stores it. In the design of test machines, the utilization of this physical phenomenon would be very beneficial. Reactive power allows for the combination of power amplification with energy savings, making it an ideal principle for conducting long-term tests that involve high loads and prolonged energy consumption. This work focuses on testing machines operating in resonance, which allows for higher test frequencies and reduced test durations. Various types of fatigue testing machines, including those with rotating-unbalance actuators, servo-hydraulic actuators, and piezoelectric actuators, are examined through vibration analysis, methodical design, and mechatronics. Resonant testing machines provide significant advantages in energy efficiency and test accuracy for a wide range of applications in materials testing. These methods are crucial for future applications in industries where energy efficiency and precise fatigue testing are critical, such as aerospace, automotive, and civil engineering.
EU-Med Capital Market Integration and the EU’s Covered Bonds Directive
Authors: Lucke Bernd 
Published: December 2024

Abstract
I analyze the potential of the EU’s Covered Bonds Directive (EU) 2019/2162 to promote the integration of Mediterranean Partner Countries (MPCs) into the EU’s Capital Market Union. I identify legal and supervisory conditions conducive for a successful development of covered bond (CB) markets. A formal model is presented to show how covered bond finance could be introduced in a banking environment in such a way that problems of asset encumbrance and unsecured debt runs are at least mitigated. Next, I study the question to what extent the EU’s covered bond framework is compatible with Islamic concepts of banking and finance? Finally, some policy objectives of EU and MPC governments are pointed out which can be expected to benefit from secured forms of bank debt funding such as covered bonds.
LA TERRITORIALIDAD DE LOS PUEBLOS ORIGINARIOS: UNA HISTORIA DE DESPOJOS Y VIOLACIONES EN EL ABYA YALA
Authors: Gonzáles-Muños Jenny 
Published: December 2024

Resumo: El territorio para los pueblos autóctonos implica una relación de identidad y de auto-construcción y el reconocimiento de su espacio comuntario que sintetiza los elementos implicados dentro de un pasado común, es decir, histórico, es la visión del mundo como el lugar donde se desarrollan todas las relaciones sociales esenciales para la continuidad cultural en una larga eventualidad de derechos y deberes colectivos. Para los pueblos indígenas de América Latina la territorialidad tiene que ver con la herencia ancestral, y no solamente como un lote de tierra capitalizable, su valor es sagrado y comunitario, y no económico. Desde el siglo XV estos pueblos han sufrido la violencias y el despojo de sus tierras ancestrales, una situación que incluso en el siglo XXI está presente.Résumé: Le territoire pour les populations autochtones implique une relation d'identité et de l'auto-construction et la reconnaissance de soi l'espace communautaire qui synthétise les éléments impliqués dans un passé commun, c'est à dire historique, c’est la vision du monde comme l'endroit où il fait toutes les relations sociales essentielles enregistré pour la continuité culturelle dans un large éventail de droits et des devoirs collectifs. Pour les peuples indigènes d'Amérique latine, la territorialité a à voir avec l'héritage ancestral, et pas seulement un morceau de terre capitalisés, sa valeur est sacrée et communautaire, et non économique. Depuis le XVe siècle, ces peuples ont souffert le viol et la dépossession de leurs terres ancestrales, une situation que même dans le XXIe siècle reste bien réel.
RELATÓRIO DA INTERVENÇÃO DE RESTAURO DE UM LEQUE MANDARIM, ACERVO DO MUSEU MUNICIPAL PARQUE DA BARONESA, PELOTAS-RS
Authors: Torino Isabel Halfen , Lacerda Bachettini Andréa 
Published: December 2024

Resumo: O presente relatório descreve as etapas de restauração de um leque chinês do século XIX, acervo do Museu Municipal Parque da Baronesa, localizado em Pelotas-RS. O trabalho observou as técnicas construtivas, a caracterização e o comportamento dos materiais constituintes da peça, concentrando-se na diversidade de matérias primas integradas neste objeto e suas interações no processo de restauro. A intenção deste estudo foi a de contribuir para a conservação e orientar para as práticas adequadas de recuperação de acervos desta tipologia para Pelotas e região. Résumé: Ce rapport décrit les étapes de restauration d’un éventail chinois du XIXe siècle, fonds du Musée Municipal Parc de la Baronne, situé à Pelotas, RS, Brésil. Ce travail a observé les techniques constructives, la caractérisation et le comportement des materiaux constituants de la pièce, en se concentrant dans la diversité de matières premières integrées dans cet objet et ses interactions dans le procès de restauration. L’intention de cet étude a été de contribuire pour la conservation et de orienter pour les pratiques adéquates de récupération de fonds de cette typologie pour Pelotas et pour la région.Abstract: This report describes the stages of restoration of a Chinese fan of the 19th century, a collection of the Baronesa Park Municipal Museum, located in Pelotas, RS. The work observed the constructive techniques, the characterization and the behavior of the constituent materials of the piece, concentrating on the diversity of raw materials integrated into this object and their interactions in the restoration process. The intention of this study was to contribute to conservation and guide the appropriate practices of recovery of collections of this typology for Pelotas and region.
Dyspareunia is rarely assessed in rodent models of endometriosis and interstitial cystitis/bladder pain syndrome
Authors: Nunez-Badinez Paulina , Shah Razneen , Demetriou Lysia , De Leo Bianca , Meijlink Jane , Birch Judy , Schmidt Nicole , Nagel Jens , Vincent Katy 
Published: December 2024

AbstractDyspareunia, or pain during sex, is a common and often debilitating symptom in individuals with endometriosis and/or interstitial cystitis/bladder pain syndrome (IC/BPS). Despite its significant impact on quality of life, it is frequently overlooked in research. This review evaluates how dyspareunia has been addressed in preclinical investigations of these conditions. A systematic search was conducted using Embase from 1998 to 2021, identifying original in vivo preclinical studies using female rodents to model (i) endometriosis and (ii) IC/BPS. The search aimed to identify studies that assessed dyspareunia. Study quality and risk of bias were evaluated using a modified CAMARADES checklist. Our analysis found 1,286 studies modelling endometriosis and 674 modelling IC/BPS, but only 18 and 1, respectively, measured dyspareunia. The most common method involved vaginal distention in rats, assessed by either behavioural escape responses or visceromotor reflexes of abdominal muscles. Despite the high prevalence of dyspareunia in these conditions, it is rarely measured in preclinical studies. We identify a significant gap in the literature and offer succinct recommendations for future translational research to address this important symptom.Lay summaryDyspareunia describes pain occurring before, during or after sexual intercourse. This poorly understood symptom is particularly common in people suffering from two chronic pain-related conditions: endometriosis and IC/BPS, severely impacting their quality of life. Therefore, effective treatments addressing painful sex in people with these conditions are needed. To see the benefits of medical research at the patient’s bedside, it is important to build from basic science research to preclinical animal studies then to human studies. Our study aims to assess the work that has been done so far at the ‘preclinical’ stage. Developments have been made in the methodology used to investigate this symptom in animals, and a summary of all the key findings may help build a platform to design future studies. Given the urgent need to develop new therapeutic strategies, attention given to painful sex by scientific medical researchers and physicians needs to improve.
Veikalas apie XX a. antrosios pusės – XXI a. pradžios knygotyrinės mokslinės draugijos veiklą Lenkijoje
Authors: Navickienė Aušra 
Published: December 2024

Koredczuk, Bożena. Badania nad książką, biblioteką i informacją w kręgu towarzystw naukowych. Komisja Bibliologii i Bibliotekoznawstwa Wrocławskiego Towarzystwa Naukowego (1953‒2003). Wrocław-Warszawa: Wydawnictwo Uniwersytetu Wrocławskiego; Komitet Historii Nauki i Techniki Pan, 2021. 506 S.
Caregivers’ Views of a Pediatric Inpatient Intervention to Address Health-Related Social Risks
Authors: Abramsohn Emily M. , Mendoza Tania A. , Bartlett Allison H. , Glasser Nathaniel J. , Grana Mellissa , Jerome Jessica , Miller Doriane C. , Murphy Jeff , O’Malley Christine , Waxman Elaine , Tessler Lindau Stacy 
Published: December 2024

OBJECTIVE
To understand the experiences of parents and caregivers of hospitalized children with CommunityRx-Hunger, a social care intervention designed to address food insecurity and other health-related social risks (HRSRs). Perspectives on how clinicians can sensitively deliver information about HRSRs in the pediatric inpatient setting were also elicited.

METHODS
In-depth, semistructured qualitative interviews were conducted (April 2022 through April 2023) with caregivers of children hospitalized at an urban academic medical center. Caregivers (N = 23) were purposefully sampled from the intervention arm of the double-blind CommunityRx-Hunger randomized controlled trial (NCT4171999). Initiated during hospital discharge, CommunityRx-Hunger includes 3 evidence-based components: education about HRSRs, delivery of HRSR-related resource information, and ongoing support to boost the intervention over 12 months. Data were analyzed using directed content analysis.

RESULTS
Most caregivers identified as the child’s mother (n = 20) and as African American or Black (n = 19) and were partnered (n = 14). Three main themes emerged: (1) positive experiences with CommunityRx-Hunger, including the sentiment that caregivers were unaware of the amount of community resources available to address HRSRs and perceptions that caregivers “were set up for success once we left the hospital”; (2) barriers to integrating social care with medical care, including concern that clinicians “are gonna use [disclosure of HRSRs] against me”; and (3) recommendations for optimizing social care delivery, including a prevalent suggestion to “just give the information” to caregivers, without asking about risks or needs.

CONCLUSION
CommunityRx-Hunger was mostly well received by caregivers. Routinely providing resource information to all caregivers of hospitalized children, regardless of need, could help alleviate concerns about disclosing HRSRs.
Thematic review of financial education and financial literacy in the digital age
Authors: Kovács Levente , Terták Elemér 
Published: December 2024

AbstractToday's world is characterised by the rapid spread of digital technology in the financial industry. Strongly connected with this development, financial products have become increasingly complex. Globalisation has increased the number of financial products offered worldwide, and almost every daily decision has a financial aspect. Thus, for the last three decades, a widening government-level agreement has emerged that individuals, particularly young people, need appropriate financial literacy to handle their finances successfully, prevent financial exclusion, and protect themselves against possible financial fraud. This deficiency is even more severe in the CEE countries, where savings, borrowing opportunities, and financial self-care options were limited; financial markets were practically non-existent.This paper reviews the existing efforts in financial education, drawing lessons from traditional methods and established channels. It also highlights recent initiatives that aim to bolster financial literacy.
Unveiling the nutritional value: Phytochemical profiling of Greek Rosa canina L. germplasm across ripening stages and fertilization treatment
Authors: GRIGORIADOU Katerina , TANOU Georgia , KOULARMANIS Konstantinos , POLYCHRONIADOU Chrysanthi , PAPANASTASI Katerina , STAVROPOULOS Georgios , MALOUPA Eleni 
Published: December 2024

Rosa canina L. is among the woody species which thrive through diverse habitats and is distinguished for its high nutritional value. In recent years R. canina L. has raised awareness due to its high demand in cosmetology and pharmacology. This study focuses on the results of a three-year experimental site including four R. canina L. genotypes treated with two fertilization regimes (conventional, organic) and harvested under four ripening stages. Τhe results indicate the most suitable period for harvesting the rosehip fruit in terms of ascorbic acid, antioxidant capacity and total phenolic compounds. This study recommends the first two ripening stages in order to achieve the highest concentration of ascorbic acid (4.53 mg g-1 F.W.). The last ripening stage came across as being the most appropriate stage for the highest total phenolic content (31.2 mg GAE g-1 FW) and in the meantime, this study highlights that the distinct ripening stages do not fluctuate the levels of total antioxidant capacity. Overall, the current study tries to identify the nutritional potential of domesticated R. canina L. and specify which of the ripening stages and fertilization regimes maximize its post-harvest value.
A ESTRATÉGIA DA ADMINISTRAÇÃO PÚBLICA EM TORNO DAS POLÊMICAS DA LEI ROUANET
Authors: Silva Júlio César , Neto Alexandre Rabelo 
Published: December 2024

Esta pesquisa investigou, por meio de uma revisão sistemática de literatura, qual foi a estratégia da Administração Pública, nos últimos quatro anos (2019 a 2022), no sentido de minimizar os impactos decorrentes das polêmicas ao redor da Lei Rouanet. Assim, por meio de um arcabouço teórico, foram apresentadas as definições da referida norma legislativa, o contexto de crise da cultura e as estratégias da Administração Pública. Dessa forma, foi possível concluir que, independentemente de posição ideológica, as estratégias utilizadas acabaram potencializando a crise no setor cultural e por consequência interpretações equivocadas, em relação à finalidade da Lei Rouanet.
Implementation of the Peruvian Earthquake Early Warning System
Authors: Lara Pablo , Tavera Hernando , Bletery Quentin , Ampuero Jean-Paul , Inza Adolfo , Portugal David , Orihuela Benazir , Meza Fernando 
Published: December 2024

ABSTRACT
We present the implementation and testing of the seismological components of the Peruvian earthquake early warning system (Sistema de Alerta Sísmica Peruano [SASPe]). SASPe is designed to send alert messages to areas located within a given distance from the epicenter of large (magnitude ≥6.0) subduction earthquakes, with a first alert based on data available 3 s after the arrival of the P wave on the nearest station. The system comprises a dedicated network of 111 strong motion stations installed along the Peruvian coast. During over 2 yr of testing, the magnitude estimates are virtually unbiased, with no false positives or false negatives. In the most critical virtual scenarios of earthquakes occurring within 57 km of populated areas, SASPe can provide user lead times of up to 8 s. For more distant areas (from 70 to 120 km), lead times range from 10 to 20 s. Once the construction of the alert broadcasting system by the civil defense authority is finalized, SASPe will provide warning to 18 million residents of the coast of Peru. We validate the algorithm of the system on recent major earthquakes in Peru and other regions, demonstrating its effectiveness and versatility for global deployment.
Intramedullary osteosynthesis for pediatric forearm re-fractures depending on the time of occurrence
Authors: Kosimov A. A. , Hodzhanov I. Yu. 
Published: December 2024

Background Tactical and technical errors in repair of pediatric forearm fractures can be associated with various complications including refractures. There are many questions regarding diagnosis (osteoreparation at the time of the occurrence) and in surgical treatment.The objective was to improve outcomes of pediatic forearm refractures treated with intramedullary osteosynthesis considering a osteoreparation period and the time of the occurrence.Material and methods There were 48 children with forearm refractures treated in the clinic between 2010 and 2020. The patients were divided into two groups. Patients of group 1 (n = 25) were treated with intramedullary osteosynthesis neglecting the regenerative process and the timing of refracture relative to the primary fracture. Patients of group 2 (n = 23) sustained a recurrent fracture at 6 months of early osteoregeneration with developing callosity. Re-fracture occurred in 19 (76.0 %) patients of group 1 including six children (24 %) with two or greater occurrences. Recurrence was observed in 16 (69.6 %) cases of group 2 including seven patients (30.4 %) who sustained more than two fractures.Results The timing of re-fractures, immobilization and gradual removal of fixation components can facilitate improved short- and long-term results of surgical treatment and prevent complications that were evident in 22 (95.6 %) children of group 2 with good results observed at 6 months.Discussion The calluses were replete with blood vessels indicating the normal regeneration for fractures that occurred at 6 months of the initial fracture. No vessels in the callus were seen after 6 months due to resorption of the bundles and poor fracture healing.Conclusion The outcome of re-consolidation would be dependent on the stage of bone regeneration at the time of forearm refracture. The regeneration process was more effective in the early stage of re-fracture.