bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated Hydrologic Study of the Arid and Semi-arid Regions using RST and GIS in the Riyadh Metropolitan Area, Saudi Arabia
Authors: Radwan Farid , Alazba A. A. 
Published: May 2021

Abstract
Water is extremely critical for human survival. It is therefore important to efficiently manage integrated water resources, which includes basins, watersheds, and wadies. In this study, the freely available data was used, which included a digital elevation model, soil and geological maps, satellite imageries, and daily precipitation records. Furthermore, remote sensing techniques and geographic information system were also integrated in this study. The linear and areal aspects, along with the longitudinal profile were also included, and the hydrologic soil groups (HSGs), land use/land cover (LULC), and curve number (CN) were identified for the main basin of the Riyadh capital. The morphometric analysis indicated that the total area of the main basin was 8500 km2, with 40 watersheds and the highest stream order as eighth. The drainage density of the main basin was 1.57 km/km2. Impermeable surface constituted most of the basin area, as group D was the most prevalently found HSG, constituting 71% of the total basin area. Additionally, the main basin had a highly steep slope, with varying elevations. Furthermore, four types of LULC were identified in the basin namely urban-based, barren land, cultivated land, and ways. The CN for every cell of the main basin ranged from 64 to 98, and the basin weighted CN was found to be 92. The potential direct runoff ranged from 10 to 59 mm. More than 70% of the total area was found to be vulnerable to high and very high runoffs (&gt; 35 mm). These values confirmed the occurrence of flood events, particularly in urban areas and cultivated lands.
The inchworm episode: Reconstituting the phenomenon of kinesin motility
Authors: Bollhagen Andrew 
Published: May 2021

AbstractNew Mechanist philosophical models of "phenomenon reconstitution" understand the process to be driven by explanatory considerations. Here I discuss an episode of phenomenon reconstitution that occurred entirely within an experimental program dedicated to characterizing (rather than explaining) the phenomenon of kinesin motility. Rather than being driven by explanatory considerations, as standard mechanist views maintain, I argue that the phenomenon of kinesin motility was reconstituted to enhance researchers’ primary experimental tool—the single molecule motility assay.
Freshwater systems and ecosystem services: Challenges and chances for cross-fertilization of disciplines
Authors: Vári Ágnes , Podschun Simone A. , Erős Tibor , Hein Thomas , Pataki Beáta , Iojă Ioan-Cristian , Adamescu Cristian Mihai , Gerhardt Almut , Gruber Tamás , Dedić Anita , Ćirić Miloš , Gavrilović Bojan , Báldi András 
Published: May 2021

AbstractFreshwater ecosystems are among the most threatened in the world, while providing numerous essential ecosystem services (ES) to humans. Despite their importance, research on freshwater ecosystem services is limited. Here, we examine how freshwater studies could help to advance ES research and vice versa. We summarize major knowledge gaps and suggest solutions focusing on science and policy in Europe. We found several features that are unique to freshwater ecosystems, but often disregarded in ES assessments. Insufficient transfer of knowledge towards stakeholders is also problematic. Knowledge transfer and implementation seems to be less effective towards South-east Europe. Focusing on the strengths of freshwater research regarding connectivity, across borders, involving multiple actors can help to improve ES research towards a more dynamic, landscape-level approach, which we believe can boost the implementation of the ES concept in freshwater policies. Bridging these gaps can contribute to achieve the ambitious targets of the EU’s Green Deal.
New Hermite–Hadamard and Jensen inequalities for log-$$s$$-convex fuzzy-interval-valued functions in the second sense
Authors: Liu Peide , Khan Muhammad Bilal , Noor Muhammad Aslam , Noor Khalida Inayat 
Published: May 2021

AbstractIn this paper, our aim is to consider the new class of log-convex fuzzy-interval-valued function known as log-s-convex fuzzy-interval-valued functions (log-s-convex fuzzy-IVFs). By this concept, we have introduced Hermite–Hadamard inequalities (HH-inequalities) by means of fuzzy order relation. This fuzzy order relation is defined level-wise through Kulisch–Miranker order relation defined on interval space. Moreover, some new Hermite–Hadamard–Fejér inequalities (HH–Fejér-inequalities) and Jensen’s inequalities via log-s-convex fuzzy-IVFs are also established and verified with the support of useful examples. Some special cases are also discussed which can be viewed as applications of fuzzy-interval HH-inequalities. The concepts and approaches of this paper may be the starting point for further research in this area.
Hydrogen atom transfer in the photochemical isomerization of hydrazones of 1,2,4-oxadiazole derivatives
Authors: D’Auria Maurizio 
Published: May 2021

AbstractDFT calculations on the photoisomerization of hydrazones of 1,2,4-oxadiazole derivatives to 1,2,5-triazoles have been performed showing that the reaction occurred through the first excited singlet state. The Z isomer gave the reaction through a hydrogen atom transfer of the hydrazonic nitrogen atom to the nitrogen atom in four position on the oxadiazole ring. In this case, the isomerization was a concerted reaction. The E isomer could undergo the same reaction. However, it could not be a concerted reaction but required the presence of a ring opening intermediate.
The hidden impacts of the ICC: An innovative assessment using Google data
Authors: Dancy Geoffrey Thomas 
Published: May 2021

AbstractCommentators now regularly declare that the International Criminal court (ICC) – and international criminal law as a whole – is in crisis. It is certainly the case that the ICC faces a number of operational challenges, and that these challenges worry its defenders. However, one unexamined rationalist assumption is that the Court’s inability to deliver consistent outputs will mean waning influence. This article explores an alternative constructivist theory that the ICC produces diffuse social impacts that are not necessarily tied to its operating effectively. This theory is tested statistically using Google Trends data. Specifically, the article examines whether ICC intervention in a country is associated with more internet search for ‘human rights’. Taking this to be a measure of changing discourse in countries, the article finds that some types of ICC involvement are associated with a far higher interest in human rights, and that this interest only increases as ICC involvement extends in time. In short, despite its disappointments, evidence suggests that the ICC still serves a socio-pedagogical function. Though it does not fit well within a rational evaluation framework, this kind of information should be considered in ICC performance reviews.
Surgical management of congenital lobar emphysema associated with CHD
Authors: Kubo Shingo , Tanaka Toshikatsu , Oshima Yoshihiro 
Published: May 2021

AbstractCongenital lobar emphysema is often associated with CHD in early infancy; however, the surgical strategy for this condition is still controversial. We report three successful cases of emphysematous lung lobectomy before the surgical repair of associated CHD. Aggressive lobectomy preceding cardiac interventions is advised when the management of congenital lobar emphysema is difficult.
A room with a view: a special issue with a special perspective
Authors: Borghesi Simone 
Published: May 2021

AbstractThe present article describes the main insights deriving from the papers collected in this special issue which jointly provide a ‘room with a view’ on some of the most relevant issues in climate policy such as: the role of uncertainty, the distributional implications of climate change, the drivers and applications of decarbonizing innovation, the role of emissions trading and its interactions with companion policies. While looking at different issues and from different angles, all papers share a similar attention to policy aspects and implications, especially in developing countries. This is particularly important to evaluate whether and to what extent the climate policies adopted thus far in developed countries can be replicated in emerging economies.
Auroral E‐Region as a Source Region for Ionospheric Scintillation
Authors: Makarevich R. A. , Crowley G. , Azeem I. , Ngwira C. , Forsythe V. V. 
Published: May 2021

AbstractAltitudinal source regions and generation mechanisms of ionospheric scintillation are investigated by employing the incoherent scatter radar (ISR) at Poker Flat, Alaska (PFISR) and nearby global positioning system (GPS) receivers. Analysis of PFISR and GPS observations during the September 2017 geomagnetic disturbances reveals that phase scintillation is seen during auroral disturbances, and can occur at any storm phase. Statistical comparisons of the rate of change of the total electron content (TEC) index (ROTI) with the amplitude (S4) and phase (σϕ) scintillation in July‐December 2017 show a significant increase with geomagnetic activity and considerable correlations between ROTI and σϕ, whereas S4 showed no noticeable increase or correlations. The PFISR‐GPS comparisons show that scintillation occurs when the electron density is enhanced in the auroral E‐region and is stronger for larger E‐region peak density and/or lower E‐region peak altitude. This implies that scintillation is stronger for more intense and/or deeper auroral particle precipitation. A detailed analysis of an event with a well‐defined and propagating E‐region density enhancement imaged by PFISR reveals that scintillation is stronger on the trailing edge of the density enhancement. This feature is discussed in the context of the gradient‐drift instability as a potential mechanism for generation of plasma density waves that scatter GPS radio signals and lead to scintillation. The results of this study add to the growing body of evidence that ROTI can be used as a proxy for phase scintillation and that the ionospheric E‐region is an important source region for ionospheric scintillation at auroral latitudes.
Modeling colorectal cancer evolution
Authors: Niida Atsushi , Mimori Koshi , Shibata Tatsuhiro , Miyano Satoru 
Published: May 2021

AbstractUnderstanding cancer evolution provides a clue to tackle therapeutic difficulties in colorectal cancer. In this review, together with related works, we will introduce a series of our studies, in which we constructed an evolutionary model of colorectal cancer by combining genomic analysis and mathematical modeling. In our model, multiple subclones were generated by driver mutation acquisition and subsequent clonal expansion in early-stage tumors. Among the subclones, the one obtaining driver copy number alterations is endowed with malignant potentials to constitute a late-stage tumor in which extensive intratumor heterogeneity is generated by the accumulation of neutral mutations. We will also discuss how to translate our understanding of cancer evolution to a solution to the problem related to therapeutic resistance: mathematical modeling suggests that relapse caused by acquired resistance could be suppressed by utilizing clonal competition between sensitive and resistant clones. Considering the current rate of technological development, modeling cancer evolution by combining genomic analysis and mathematical modeling will be an increasingly important approach for understanding and overcoming cancer.
Interfering with hyaluronic acid metabolism suppresses glioma cell proliferation by regulating autophagy
Authors: Yan Tao , Chen Xin , Zhan Hua , Yao Penglei , Wang Ning , Yang He , Zhang Cheng , Wang Kaikai , Hu Hong , Li Jiafeng , Sun Jingxian , Dong Yu , Lu Enzhou , Zheng Zhixing , Zhang Ruotian , Wang Xiaoxiong , Ma Jichao , Gao Ming , Ye Junyi , Wang Xinzhuang , Teng Lei , Liu Huailei , Zhao Shiguang 
Published: May 2021

AbstractThe tumor microenvironment plays an important role in tumor progression. Hyaluronic acid (HA), an important component of the extracellular matrix in the tumor microenvironment, abnormally accumulates in a variety of tumors. However, the role of abnormal HA accumulation in glioma remains unclear. The present study indicated that HA, hyaluronic acid synthase 3 (HAS3), and a receptor of HA named CD44 were expressed at high levels in human glioma tissues and negatively correlated with the prognosis of patients with glioma. Silencing HAS3 expression or blocking CD44 inhibited glioma cell proliferation in vitro and in vivo. The underlying mechanism was attributed to the inhibition of autophagy flux and maintaining glioma cell cycle arrest in G1 phase. More importantly, 4-methylumbelliferone (4-MU), a small competitive inhibitor of Uridine diphosphate (UDP) with the ability to penetrate the blood-brain barrier (BBB), also inhibited glioma cell proliferation in vitro and in vivo. Thus, approaches that interfere with HA metabolism by altering the expression of HAS3 and CD44 and the administration of 4-MU potentially represent effective strategies for glioma treatment.
RNA m6A reader YTHDF2 facilitates lung adenocarcinoma cell proliferation and metastasis by targeting the AXIN1/Wnt/β-catenin signaling
Authors: Li Yin , Sheng Hao , Ma Feng , Wu Qiang , Huang Jianfang , Chen Qiang , Sheng Lianghe , Zhu Xinghai , Zhu Xiaoxi , Xu Meng 
Published: May 2021

AbstractLung adenocarcinoma (LUAD) remains a leading cause of cancer-related deaths worldwide. YTHDF2 is a reader of N6-methyladenosine (m6A) on RNA and plays a critical role in the initiation and propagation of myeloid leukemia; however, whether YTHDF2 controls the development of LUAD remains to be explored. Here, we found that YTHDF2 was significantly upregulated in LUAD compared with paracancerous normal tissues, and YTHDF2 knockdown drastically inhibited, while its overexpression promoted, cell growth, colony formation and migration of LUAD cells in vitro. In addition, YTHDF2 knockdown significantly inhibited tumorigenesis in a murine tumor xenograft model. Through the integrative analysis of RNA-seq, m6A-seq, CLIP-seq, and RIP-seq datasets, we identified a set of potential direct targets of YTHDF2 in LUAD, among which we confirmed AXIN1, which encodes a negative regulator of the Wnt/β-catenin signaling, as a direct target of YTHDF2. YTHDF2 promoted AXIN1 mRNA decay and subsequently activated the Wnt/β-catenin signaling. Knockout of AXIN1 sufficiently rescued the inhibitory effect of YTHDF2 depletion on lung cancer cell proliferation, colony-formation, and migration. These results revealed YTHDF2 to be a contributor of LUAD development acting through the upregulation of the AXIN1/Wnt/β-catenin signaling, which can be a potential therapeutic target for LUAD.
Prevention of D-GalN/LPS-induced ALI by 18β-glycyrrhetinic acid through PXR-mediated inhibition of autophagy degradation
Authors: Wu Shouyan , Lu Henglei , Wang Wenjie , Song Luyao , Liu Meng , Cao Yuhan , Qi Xinming , Sun Jianhua , Gong Likun 
Published: May 2021

AbstractAcute liver injury (ALI) has multiple causes and results in liver dysfunction. Severe or persistent liver injury eventually leads to liver failure and even death. Pregnane X receptor (PXR)-null mice present more severe liver damage and lower rates of autophagy. 18β-glycyrrhetinic acid (GA) has been proposed as a promising hepatoprotective agent. We hypothesized that GA significantly alleivates D-GalN/LPS-induced ALI, which involved in PXR-mediated autophagy and lysosome biogenesis. We found that GA can significantly decrease hepatocyte apoptosis and increase the hepatic autophagy marker LC3-B. Ad-mCherry-GFP-LC3 tandem fluorescence, RNA-seq and real-time PCR indicated that GA may stabilize autophagosomes and lysosomes and inhibit autophagosome–lysosome fusion. Simultaneously, GA markedly activates PXR, even reversing the D-GalN/LPS-induced reduction of PXR and its downstream genes. In contrast, GA has a weak protective effect in pharmacological inhibition of PXR and PXR-null mice, which significantly affected apoptosis- and autophagy-related genes. PXR knockout interferes with the stability of autophagosomes and lysosomes, preventing GA reducing the expression of lysosomal genes such as Cst B and TPP1, and suppressing autophagy flow. Therefore, we believe that GA increases autophagy by inhibiting autophagosome–lysosome fusion and blocked autophagy flux via activation of PXR. In conclusion, our results show that GA activates PXR to regulate autophagy and lysosome biogenesis, represented by inhibiting autophagosome–lysosome fusion and stabilization of lysosome. These results identify a new mechanism by which GA-dependent PXR activation reduces D-GalN/LPS-induced acute liver injury.
Balancing scientific interests and the rights of participants in designing a recall by genotype study
Authors: Mascalzoni Deborah , Biasiotto Roberta , Borsche Max , Brüggemann Norbert , De Grandi Alessandro , Goegele Martin , Frygner-Holm Sara , Klein Christine , Kösters Maria , Staunton Ciara , Pramstaller Peter P. , Krawczak Michael , Hicks Andrew A. 
Published: May 2021

AbstractRecall by genotype (RbG) studies aim to better understand the phenotypes that correspond to genetic variants of interest, by recruiting carriers of such variants for further phenotyping. RbG approaches pose major ethical and legal challenges related to the disclosure of possibly unwanted genetic information. The Cooperative Health Research in South Tyrol (CHRIS) study is a longitudinal cohort study based in South Tyrol, Italy. Demand has grown for CHRIS study participants to be enrolled in RbG studies, thus making the design of a suitable ethical framework a pressing need. We here report upon the design of a pilot RbG study conducted with CHRIS study participants. By reviewing the literature and by consulting relevant stakeholders (CHRIS participants, clinical geneticists, ethics board, GPs), we identified key ethical issues in RbG approaches (e.g. complexity of the context, communication of genetic results, measures to further protect participants). The design of the pilot was based on a feasibility assessment, the selection of a suitable test case within the ProtectMove Research Unit on reduced penetrance of hereditary movement disorders, and the development of appropriate recruitment and communication strategies. An empirical study was embedded in the pilot study with the aim of understanding participants’ views on RbG. Our experience with the pilot study in CHRIS allowed us to contribute to the development of best practices and policies for RbG studies by drawing recommendations: addressing the possibility of RbG in the original consent, implementing tailored communication strategies, engaging stakeholders, designing embedded empirical studies, and sharing research experiences and methodology.
Rational construction of a reversible arylazo-based NIR probe for cycling hypoxia imaging in vivo
Authors: Zhang Yuming , Zhao Wenxuan , Chen Yuncong , Yuan Hao , Fang Hongbao , Yao Shankun , Zhang Changli , Xu Hongxia , Li Nan , Liu Zhipeng , Guo Zijian , Zhao Qingshun , Liang Yong , He Weijiang 
Published: May 2021

AbstractReversible NIR luminescent probes with negligible photocytotoxicity are required for long-term tracking of cycling hypoxia in vivo. However, almost all of the reported organic fluorescent hypoxia probes reported until now were irreversible. Here we report a reversible arylazo-conjugated fluorescent probe (HDSF) for cycling hypoxia imaging. HDSF displays an off-on fluorescence switch at 705 nm in normoxia-hypoxia cycles. Mass spectroscopic and theoretical studies confirm that the reversible sensing behavior is attributed to the two electron-withdrawing trifluoromethyl groups, which stabilizes the reduction intermediate phenylhydrazine and blocks the further reductive decomposition. Cycling hypoxia monitoring in cells and zebrafish embryos is realized by HDSF using confocal imaging. Moreover, hypoxic solid tumors are visualized and the ischemia-reperfusion process in mice is monitored in real-time. This work provides an effective strategy to construct organic fluorescent probes for cycling hypoxia imaging and paves the way for the study of cycling hypoxia biology.
Crystallization of nanoparticles induced by precipitation of trace polymeric additives
Authors: Qian Yiwen , da Silva Alessandra , Yu Emmy , Anderson Christopher L. , Liu Yi , Theis Wolfgang , Ercius Peter , Xu Ting 
Published: May 2021

AbstractOrthogonal to guided growth of nanoparticle (NP) crystals using DNA or supramolecules, a trace amount of polymeric impurities (<0.1 wt.%) leads to reproducible, rapid growth of 3D NP crystals in solution and on patterned substrates with high yield. When polymers preferentially precipitate on the NP surfaces, small NP clusters form and serve as nuclei for NP crystal growth in dilute solutions. This precipitation-induced NP crystallization process is applicable for a range of polymers, and the resultant 3-D NP crystals are tunable by varying polymeric additives loading, solvent evaporation rate, and NP size. The present study elucidates how to balance cohesive energy density and NP diffusivity to simultaneously favor nuclei formation energetically and kinetic growth in dilute solutions to rapidly crystalize NPs over multiple length scales. Furthermore, the amount of impurities needed to grow NP crystals (<0.1%) reminds us the importance of fine details to interpret experimental observations in nanoscience.
A hierarchical 3D-motion learning framework for animal spontaneous behavior mapping
Authors: Huang Kang , Han Yaning , Chen Ke , Pan Hongli , Zhao Gaoyang , Yi Wenling , Li Xiaoxi , Liu Siyuan , Wei Pengfei , Wang Liping 
Published: May 2021

AbstractAnimal behavior usually has a hierarchical structure and dynamics. Therefore, to understand how the neural system coordinates with behaviors, neuroscientists need a quantitative description of the hierarchical dynamics of different behaviors. However, the recent end-to-end machine-learning-based methods for behavior analysis mostly focus on recognizing behavioral identities on a static timescale or based on limited observations. These approaches usually lose rich dynamic information on cross-scale behaviors. Here, inspired by the natural structure of animal behaviors, we address this challenge by proposing a parallel and multi-layered framework to learn the hierarchical dynamics and generate an objective metric to map the behavior into the feature space. In addition, we characterize the animal 3D kinematics with our low-cost and efficient multi-view 3D animal motion-capture system. Finally, we demonstrate that this framework can monitor spontaneous behavior and automatically identify the behavioral phenotypes of the transgenic animal disease model. The extensive experiment results suggest that our framework has a wide range of applications, including animal disease model phenotyping and the relationships modeling between the neural circuits and behavior.
Enantioselective access to chiral aliphatic amines and alcohols via Ni-catalyzed hydroalkylations
Authors: Wang Shan , Zhang Jian-Xin , Zhang Tian-Yi , Meng Huan , Chen Bi-Hong , Shu Wei 
Published: May 2021

AbstractChiral aliphatic amine and alcohol derivatives are ubiquitous in pharmaceuticals, pesticides, natural products and fine chemicals, yet difficult to access due to the challenge to differentiate between the spatially and electronically similar alkyl groups. Herein, we report a nickel-catalyzed enantioselective hydroalkylation of acyl enamines and enol esters with alkyl halides to afford enantioenriched α-branched aliphatic acyl amines and esters in good yields with excellent levels of enantioselectivity. The operationally simple protocol provides a straightforward access to chiral secondary alkyl-substituted amine and secondary alkyl-substituted alcohol derivatives from simple starting materials with great functional group tolerance.