bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-resolution three‑dimensional contrast‑enhanced magnetic resonance venography in children: comparison of gadofosveset trisodium with ferumoxytol
Authors: Shahrouki Puja , Khan Sarah N. , Yoshida Takegawa , Iskander Paul J. , Ghahremani Shahnaz , Finn J. Paul 
Published: December 2021

Abstract
Background
Gadofosveset is a gadolinium-based blood pool contrast agent that was approved by the United States Food and Drug Administration in 2008. Its unanticipated withdrawal from production in 2016 created a void in the blood pool agent inventory and highlighted the need for an alternative agent with comparable imaging properties.

Objective
The purpose of our study is to compare the diagnostic image quality, vascular contrast-to-noise ratio (CNR) and temporal signal characteristics of gadofosveset trisodium and ferumoxytol at similar molar doses for high-resolution, three-dimensional (3-D) magnetic resonance (MR) venography in children.

Materials and methods
The medical records and imaging data sets of patients who underwent high-resolution 3-D gadofosveset-enhanced MR venography (GE-MRV) or ferumoxytol-enhanced MR venography (FE-MRV) were retrospectively reviewed. Two groups of 20 pediatric patients (age- and weight-matched with one patient common to both groups; age range: 2 days–15 years) who underwent high-resolution 3-D GE-MRV or FE-MRV at similar molar doses were identified and analyzed. Qualitative analysis of image quality and vessel definition was performed by two blinded pediatric radiologists. Interobserver agreement was assessed with the AC1 (first-order agreement coefficient) statistic. Signal-to-noise ratio (SNR) and CNR of the inferior vena cava and aorta were measured in the steady-state venous phase. Medical records were retrospectively reviewed for any adverse reactions associated with either contrast agent.

Results
Measured SNR and CNR of the inferior vena cava were higher for FE-MRV than GE-MRV (P = 0.034 and P < 0.001, respectively). The overall image quality score and individual vessel scores of FE-MRV were equal to or greater than GE-MRV (P = 0.084), with good interobserver agreement (AC1 = 0.657). The venous signal on FE-MRV was stable over the longest interval measured (1 h, 13 min and 46 s), whereas venous signal on GE-MRV showed more variability and earlier loss of signal. No adverse reactions were noted in any patient with either contrast agent.

Conclusion
Ferumoxytol produces more uniform and stable enhancement throughout the entire venous circulation in children than gadofosveset, offering a wider time window for optimal image acquisition. FE-MRV offers a near-ideal approach to high-resolution venography in children at all levels of anatomical complexity.
Immunogenicity of the BNT162b2 mRNA COVID-19 vaccine in older residents of a long-term care facility: relation with age, frailty and prior infection status
Authors: Seiffert Piotr , Konka Adam , Kasperczyk Janusz , Kawa Jacek , Lejawa Mateusz , Maślanka-Seiffert Barbara , Zembala-John Joanna , Bugdol Monika , Romanik Małgorzata , Bułdak Rafał , Marcisz Czesław , Derejczyk Jarosław , Religa Dorota 
Published: December 2021

AbstractClinical and biological assessment of the COVID-19 vaccine efficacy in the frail population is of crucial importance. The study focuses on measuring the levels of anti-SARS-CoV-2 IgG antibodies before and after BNT162b2 mRNA COVID-19 vaccination among long-term care facility (LTCF) elderly residents. We conducted a prospective, single-center, observational study among LTCF residents. The study protocol was based on three blood sample acquisitions: first taken at baseline—5 days before the first dose of the vaccine, second—20 days after the first dose, and third—12 days after the second shot of the vaccine. The comparison was made for two cohorts: patients with and without prior COVID-19 infection. The data was collected from January to March 2021. A total number of 78 LTCF residents (55 women and 23 men) aged 62–104, 85.72 ± 7.59 years (mean ± SD), were enrolled in the study. All study participants were investigated for the presence of SARS-CoV-2 anti-spike (S) protein IgG, using a chemiluminescent immunoassay. Frailty was assessed with the Clinical Frailty Scale. Among elderly COVID-19 survivors in LTCF, a single dose of vaccine significantly increased anti-SARS-CoV-2 IgG antibody levels. IgG concentration after a single and double dose was comparable, which may suggest that elderly COVID-19 survivors do not require a second dose of vaccine. For residents without a previous history of COVID-19, two doses are needed to achieve an effective serological response. The level of anti-SARS-CoV-2 IgG antibodies after vaccination with BNT162b2 mRNA COVID-19 did not correlate with the frailty and age of the studied individuals.
50 Years of Capital Mobility in the Eurozone: Breaking the Feldstein-Horioka Puzzle
Authors: Camarero Mariam , Muñoz Alejandro , Tamarit Cecilio 
Published: December 2021

AbstractThis paper assesses capital mobility for the Eurozone countries by studying the long-run relationship between domestic investment and savings for the period 1970-2019. Our main goal is to analyze the impact of economic events on capital mobility during this period. We apply the cointegration methodology in a setting that allows us to identify endogenous breaks in the long-run saving-investment relationship. Precisely, the breaks coincide with relevant economic events. We find a downward trend in the saving-investment retention since the 70s for the so-called “core countries”, whereas this trend is not so evident in the peripheral, where the financial and sovereign crises have had a more substantial impact. In addition, our analysis captures other economic events: the Exchange Rate Mechanism (ERM) crisis, the German reunification, the European financial assistance program, and the post-crisis period. Our results also indicate that the original euro design had some flaws that remain unsolved.
Social support and health-related quality of life among the oldest old — longitudinal evidence from the multicenter prospective AgeCoDe-AgeQualiDe study
Authors: Hajek André , Brettschneider Christian , Mallon Tina , Kaduszkiewicz Hanna , Oey Anke , Wiese Birgitt , Weyerer Siegfried , Werle Jochen , Pentzek Michael , Fuchs Angela , Conrad Ines , Luppa Melanie , Weeg Dagmar , Mösch Edelgard , Kleineidam Luca , Wagner Michael , Scherer Martin , Maier Wolfgang , Riedel-Heller Steffi G. , König Hans-Helmut 
Published: December 2021

Abstract
Purpose
The aim of this study was to examine the longitudinal within-association between social support and health-related quality of life among the oldest old.

Methods
Longitudinal data (follow-up waves 7 to 9) were used from the multicenter prospective cohort study “Needs, health service use, costs and health-related quality of life in a large sample of oldest-old primary care patients (85 +)” (AgeQualiDe). n = 648 individuals were included in the analytical sample. At FU wave 7, mean age was 88.8 years (SD: 2.9 years, from 85 to 99 years). Social support was quantified using the Lubben Social Network Scale (6-item version). Health-related quality of life was assessed using the EQ-5D-3L including problems in five health dimensions, and its visual analogue scale (EQ VAS). It was adjusted for several covariates in conditional logistic and linear fixed effects regressions.

Results
Intraindividual decreases in social support were associated with an increased likelihood of developing problems in ‘self-care’, ‘usual activities’, ‘pain/discomfort’ and ‘anxiety/depression’ (within individuals over time). In contrast, intraindividual changes in social support were not associated with intraindividual changes in the EQ VAS score.

Conclusion
Findings indicate a longitudinal intraindividual association between social support and problems, but only in some health dimensions. Further research in this area based on longitudinal studies among the oldest old (from different countries) is required.
Using the dendro-climatological signal of urban trees as a measure of urbanization and urban heat island
Authors: Schneider Christoph , Neuwirth Burkhard , Schneider Sebastian , Balanzategui Daniel , Elsholz Stefanie , Fenner Daniel , Meier Fred , Heinrich Ingo 
Published: December 2021

AbstractUsing dendroclimatological techniques this study investigates whether inner city tree-ring width (TRW) chronologies from eight tree species (ash, beech, fir, larch, lime, sessile and pedunculate oak, and pine) are suitable to examine the urban heat island of Berlin, Germany. Climate-growth relationships were analyzed for 18 sites along a gradient of increasing urbanization covering Berlin and surrounding rural areas. As a proxy for defining urban heat island intensities at each site, we applied urbanization parameters such as building fraction, impervious surfaces, and green areas. The response of TRW to monthly and seasonal air temperature, precipitation, aridity, and daily air-temperature ranges were used to identify climate-growth relationships. Trees from urban sites were found to be more sensitive to climate compared to trees in the surrounding hinterland. Ring width of the deciduous species, especially ash, beech, and oak, showed a high sensitivity to summer heat and drought at urban locations (summer signal), whereas conifer species were found suitable for the analysis of the urban heat island in late winter and early spring (winter signal).The summer and winter signals were strongest in tree-ring chronologies when the urban heat island intensities were based on an area of about 200 m to 3000 m centered over the tree locations, and thus reflect the urban climate at the scale of city quarters. For the summer signal, the sensitivity of deciduous tree species to climate increased with urbanity.These results indicate that urban trees can be used for climate response analyses and open new pathways to trace the evolution of urban climate change and more specifically the urban heat island, both in time and space.
Comparison of 3R4F cigarette smoke and IQOS heated tobacco product aerosol emissions
Authors: Kärkelä Teemu , Tapper Unto , Kajolinna Tuula 
Published: December 2021

AbstractIn this study, the smoke from a 3R4F research cigarette and the aerosol generated by the Heated Tobacco Product IQOS, also referred to as the Tobacco Heating System (THS) 2.2 in the literature, were compared. The objective was to characterize the gas and suspended particulate matter compositions in the mainstream smoke from a combusted 3R4F cigarette and in the aerosol generated by IQOS during use. The results indicated that the determined aerosol emissions from IQOS were notably lower than in the cigarette smoke under a Health Canada Intense puffing regimen. As an interesting detail in this study, the maximum nicotine concentrations within a puff were practically the same in both the 3R4F smoke and the IQOS aerosol, but the average concentration was lower for the IQOS aerosol. For both products, water constituted a significant proportion of the particulate matter, although it was substantially higher in the IQOS aerosol. Furthermore, combustion-related solid particles observed in the 3R4F smoke contained elements such as carbon, oxygen, potassium, calcium, and silicon. In contrast, IQOS aerosol particulate matter was composed of semi-volatile organic constituents with some minor traces of oxygen and silicon. The particulate matter found in the IQOS aerosol was volatile, which was especially noticeable when exposed to the electron beam of the scanning electron microscope (SEM) and Transmission Electron Microscope (TEM).
Sea state from ocean video with singular spectrum analysis and extended Kalman filter
Authors: Loizou Antonis , Christmas Jacqueline 
Published: December 2021

AbstractA method for estimating key parameters of ocean waves (the dominant frequency and the significant wave height) from uncalibrated monoscopic video is proposed, based on temporal variation of the wave field, specifically time series of pixel intensities. The methodology tracks the principal component of the movement of water in the video, which we propose is associated with the dominant frequency of the ocean. To accomplish this, the singular spectrum analysis algorithm and the extended Kalman filter are used. Then, the shape of an empirical spectrum is used in order to translate the dominant frequency output into a significant wave height estimation.
Bcl2 inhibitor venetoclax +/− Anti-CD20: what do deep remissions mean?
Authors: Prochazka Katharina T. , Uhl Barbara 
Published: December 2021

SummaryIn recent years, treatment of patients exhibiting chronic lymphocytic leukemia has changed extensively due to advances in the development of targeted therapies. The Bcl‑2 inhibitor venetoclax demonstrated outstanding results when used in mono- as well as combination therapy. Minimal residual disease (MRD) measurement has become an important endpoint in most studies and shows high prognostic potential. With upcoming combination strategies, the role of MRD measurement has also increased and is likely to become a routine marker in future clinical practice.
Analyzing the correlation between stochastic fracture networks geometrical properties and stress variability: a rock and fracture parameters study
Authors: Khodaei Meysam , Biniaz Delijani Ebrahim , Hajipour Mastaneh , Karroubi Kasra , Dehghan Ali Naghi 
Published: December 2021

AbstractIn this study, the correlation between geometric properties of the fracture network and stress variability in a fractured rock was studied. Initially, discrete fracture networks were generated using a stochastic approach, then, considering the tensorial nature of stress, the stress field under various tectonic stress conditions was determined using finite-difference method. Ultimately, stress data were analyzed using tensor-based mathematical relations. Subsequently, the effects of four parameters including rock tensile strength, rock cohesion, fracture normal stiffness and fracture dilation angle on the stress perturbation distribution were evaluated. The obtained results indicated that stress perturbation and dispersion are directly related to fracture density, which is expressed as the number of fractures per unit area utilizing the window sampling approach. It was also demonstrated that they are inversely related to power-law length exponent which represents the length of fracture. It was observed that stress distribution, among the evaluated parameters, is more sensitive to the fracture normal stiffness and the effects of rock parameters on stress distribution are negligible. It was concluded that the highest stress distribution is created when the fracture network is dense with fractures having high length and low normal stiffness value.
Semi-analytical model to predict the performance of cyclic steam stimulation oil wells
Authors: Basta George , Abu El Ela Mahmoud , El-Banbi Ahmed , El-Tayeb Sayed , Desouky Saad El-Din Mohamed , Sayyouh Mohamed Helmy 
Published: December 2021

AbstractPrediction of the performance of oil wells under Cyclic Steam Stimulation (CSS) is challenging in complex and heterogeneous reservoirs, especially with limited data. Analytical and numerical simulation models do not usually give accurate predictions in such conditions. In this work, a semi-analytical model was developed to determine consistent mathematical relationships between the injected steam and some of the effective oil production parameters for more accurate prediction of oil production rates. Field investigation indicates that the change of the Cumulative Oil to Steam Ratio (COSR) to production days is related to a group of effective oil production parameters. This group of parameters includes the cumulative injected steam relative to the drainage volume, the oil net pay thickness relative to the gross pay thickness, and the vertical permeability relative to the thermal diffusivity. These parameters were arranged in two dimensionless groups. It was found that plotting these two dimensionless groups on Log–Log scale for any reservoir yields a straight line (correlation). For any reservoir under CSS, measurements of two steam cycles are sufficient to identify the constants of the proposed correlation. This method has been applied and validated on six reservoirs with different reservoir characterizations. Six different wells with a total of 43 steam cycles from these reservoirs were analyzed with the same approach. The mathematical relationships of the dimensionless groups were calculated, and the Log–Log plot was constructed for each well using the data of the first two cycles. Then, the proposed correlation was developed for each well and used to predict the well performance starting from the third steam cycle. At the end, the predicted performance of each well was compared with the corresponding actual measurements. The results showed that the average absolute percentage deviation between the actual and the predicted cumulative oil production through the well lifetime is less than 5% for the six wells. In addition, the absolute instantaneous deviation between the actual and the predicted cumulative oil production for each individual cycle in all cases is (1) less than 15% for about 42% of the tested CSS cycles, (2) between 15 to 25% for about 39% of the tested CSS cycles, and (3) higher than 25% for about 19% of the tested CSS cycles. This work is considered an original contribution to develop dimensionless relationships that can be used to predict the oil production of the CSS operations for reservoirs with limited data. The required data are the historical production rate, steam injection rate, and basic petrophysical parameters.
Indications of sandstone-type uranium mineralization from 3D seismic data: a case study of the Qiharigetu deposit, Erenhot Basin, China
Authors: Wu Qubo , Huang Yucheng 
Published: December 2021

AbstractThe primary exploration objective of Qiharigetu Sandstone-type Uranium (SU) deposit in the Erenhot Basin of China is to understand the stratigraphy, lithology and fault distribution of the target layer. Various geophysical techniques including gravity, magnetic, electromagnetic and 2D seismic have been proved not very effective due to its shallow depth of burial and small geophysical differences between layers. A specific 3D seismic survey of the Qiharigetu SU deposit has been carried out, and the inferred geological features of the uranium mineralization could provide important references for subsequent drilling programs. It is deduced that the target layer in the central part of the study area has a local "depression" through 3D seismic imaging and interpretation, which is conducive to river runoff and formation of sand body, as the sand body is a necessary precondition for mineralization. There are faults (5–50 m in throw) striking north–south for around 2 km, and it is an important ore-controlling factor, which could provide channels for the rise of reducing agents (such as gas, H2S, and coalbed methane) at depth as they can promote the redox reaction for mineralization. The 3D seismic inversion is used to estimate the impedance, lithology, sand content and porosity of the target layer. With the help of drilling verification, it is found that the area with sand content over 75% and porosity over 10% is favorable for the SU deposit. Compared with other geophysical techniques, 3D seismic method is able to provide high-resolution images for unraveling SU mineralization and thereby reduce the drilling risk of the SU deposit.
Standardisation efforts of ISO/TC 261 “Additive Manufacturing”: 17th plenary meeting of ISO/TC 261 “Additive Manufacturing”
Authors: Pei Eujin 
Published: December 2021

AbstractThe main objective of ISO/TC 261 is to standardise the processes of additive manufacturing, the process chains (data, materials, processes, hard- and software, applications), test procedures, quality parameters, supply agreements, environment, health and safety, fundamentals and vocabularies. This section provides readers with news regarding standardisation efforts of ISO/TC 261.
Blood Flow of Peripheral Nerve Effects of Dissection, Stretching and Compression
Authors: OGATA KOSUKE , NAITO MASATOSHI 
Published: December 2021

Blood flow rate of the peripheral nerve was measured using the hydrogen washout technique and the effects of dissection, stretching and compression were studied on blood flow of the rabbit sciatic nerve. Regional surgical dissections revealed that a proximal portion of the sciatic nerve receives its blood supply from gluteal vessels whereas a distal portion receives from popliteal vessels. Blood flow direction in the proximal half of the sciatic nerve in the thigh was found to be distal whereas in the distal half to be proximal. The longitudinal pathway appeared to be capable of compensating for local diminution of blood flow. The average stretching of more than 15.7% caused complete arrest of blood flow in the stretched nerve. The average stretching force at this point was 74 grams. Complete standstill of intraneural circulation was observed under compression of 50 to 70 mm Hg, or 60 to 80% of mean arterial pressure. These values of critical stretching and compression on the intraneural blood flow corresponds well with those previously reported by Lundborg, 1973; Rydevik, 1981).
The Incidence of a Palmaris Longus Tendon in Patients with Dupuytren’s Disease
Authors: POWELL B. W. E. M. , McLEAN N. R. , JEFFS J. V. 
Published: December 2021

The incidence of a palmaris longus tendon in patients with Dupuytren’s disease is significantly greater than in a control group with normal hands (p = 0.014). If a patient has a palmaris longus tendon, then there is a highly significant chance of Dupuytren’s disease developing in that hand (p<0.00l).
Studies on Tendon Healing A Comparison Between Suturing Techniques
Authors: DEFINO H. L. A. , BARBIERI C. H. , GONCALVES R. P. , PAULIN J. B. P. 
Published: December 2021

An experimental study comparing Kessler’s and Tsuge’s techniques for tendon suture was undertaken in dogs. Both second and fifth flexor digitorum profundi tendons of the left forepaw were divided in the segment corresponding to zone 2 of human hands. Following division, the tendons to the second digit were repaired by Kessler’s technique and those to the fifth digit by Tsuge’s method. Results were evaluated by means of standard and polarized – light microscopy, intravascular dye injections and tensile strength tests. Both ordinary and polarized – light microscopy showed that a microscopical gap develops between the tendon ends, being filled in with healing tissue which undergoes progressive maturation. The tensile strength tests showed that the deformation (elongation) progress directly with load, up to the point of rupture; the suture thread does not interfere with this. Furthermore, strength increases with time. Intravascular dye injection showed that a net of newly formed blood vessels develops at the site of section and suture, previously destitute of macroscopical vessels. The new vessels tended to redistribute them selves to resemble the pattern in normally vascularized regions. It was not possible to detect, by means of the methods employed, any important difference between Kessler’s and Tsuge’s techniques for tendon suture.