bluuebunny/crossref_metadata_2025_split huggingface dataset:
FEATURES OF USING THE AUTHOR'S MODEL OF SPEECH GENERATION IN ORDER TO INCREASE THE COMMUNICATIVE COMPETENCE OF UNIVERSITY STUDENTS
Authors: Гаврилов Виктор Викторович 
Published: February 2021

Исследованы особенности использования авторской модели речепорождения в рамках курса «Русский язык и культура речи». Обозначены ранее изученные аспекты проблемы: теоретические предпосылки, понятийный аппарат. Предложена и описана авторская модель речепорождения. Доказывается необходимость перехода от формальных аспектов (изучение норм русского литературного языка, формул делового общения и тестирования как основного вида контроля) к развитию мышления обучающихся на основе теории интериоризации. С целью верификации результатов работы с использованием авторской модели речепорождения были определены критерии оценки текстов выступлений обучающихся. Представлены результаты педагогического эксперимента, проведенного в 2108-2019 уч. г.: сравнивался уровень развития коммуникативной компетенции в контрольной и экспериментальной группах. Результаты демонстрируют эффективность использования предложенной модели речепорождения. Результаты исследования могут быть использованы для разработки технологий обучения русскому языку и культуре речи.
The article is devoted to the peculiarities of using the author's model of speech generation in the course «Russian language and culture of speech». The necessity of transition from formal aspects (studying the norms of the Russian literary language, formulas of business communication and testing as the main type of control) to the development of students ' thinking based on the theory of interiorization is proved. The effectiveness of the proposed method is confirmed by the ability of students to create original texts of speeches, which take into account both external factors (audience characteristics, goals, conditions of speech interaction) and the speaker's intentions.
Dampak Penggunaan Gadget Terhadap Perkembangan Anak
Authors: Nafaida Rizky , , Nurmasyitah , , Nursamsu 
Published: February 2021

Penelitian ini bertujuan untuk mengetahui penguatan gadget terhadap perkembangan karakter anak. metode penelitian adalah yang digunakan dalam penelitian berupa metode deskriptif. Pengumpulan data dilkasanakan mengunakan observasi dan angket sedangkan pada analisa data dilakukan dengan reduksi data, penyajian data, penyimpulan dan verifikasi data. Hasil penelitian dinyakan dengan nilai 76,80% dinyatakan baik karakter religius, karakter peduli sosial dengan nilai 73,87% dinyatakan baik, karakter disiplin dinyatakan baik dengan nilai 67,73%, sedangkan karakter tanggung jawab dengan nilai 76,53% dinyatakan baik. Maka dapat disimpulkan bahwa penggunaan gadget terdapat dampak positif dan negatif bagi anak
Efecto de tratamientos pregerminativos de hidratación-deshidratación sobre la viabilidad y germinación de semillas de Setaria sphacelata
Authors: Tamborelli Melina Rut , Fiant Silvina Elisabeth 
Published: February 2021

Setaria sphacelata is a tropical forage grass, cultivated in diverse regionsdue to its plasticity. Like other summer perennial forages, it has a slow establishment. Hydration-dehydration (HD) pregerminative treatments improve the germination and establishment of many species. The objective of this work was to evaluate the effect of HD with water and potassium nitrate on Setariasphacelata seeds. A factorial treatment design of 2 x 3 x 2 was applied. The first factor was the imbibitory agent: water (A) and potassium nitrate at 2 % (N); the second the imbibition time: 24, 48 and 72 hours; and the third the lot evaluated (two). Four repetitions of 50 seeds per treatment and one control (T) were sown. Germinative energy, germination percentage, fresh and dead seeds (SM) were recorded. Between lots, only significant differences were found in SM. The treatments A24, A48, A72 and N24 were better than T in speed and percentage of germination, while N48 and N72 were similar or inferior. It is concluded that HD treatment with water for 72 hours proved to be the best treatment. Immersion for more than 24 hours in potassium nitrate at 2 % impaired seed viability.
TEACHING LEARNING PROCESS OF A SYNTAX CLASS AT KRESNA ENGLISH LANGUANGE INSTITUTE PARE KEDIRI
Authors: Santoso Didik 
Published: February 2021

The study is aimed to describe the teaching learning process of Syntax Class at Kresna English Language Institute. Those are including of:The teaching learning process, the English teacher’s problem, the problem solving of teacher, the student’s response, and the appropriate material for student.This research design used descriptive qualitative. The subjects were a teacher and 25 students of Syntax Class. The methods were observation, interview, and documentation. Observation used for collecting data on the teaching learning process that consisted of: lesson plan, the material, method, and media that the teachers used in teaching. Interview used for collecting data on the teachers’ preparation, students’ response, and the teachers’ evaluation in teaching learning process. Documentation was used to collect data about a record of events that have passed. This research had some results: (1the teaching learning process was running well by some phases such as : preparation, implementation and evaluation, (2) the problems of the teacher happened in implementation and in evalution phases,(3) in implementation, the problem faced by some advices and even punishment to the student and in evaluation the problem solved by giving motivation and additional duty,(4) there were more positive responses than negative responses from the students, ( 5 ) the appropriate material in this class was Syntactic stucture and sentence analysis. Theconclusion of this reseach was that the teaching learning process ran well, but there were some activities of teacher that were not suitable with lesson plan.
ABC: How It Plays Out in A Cross-Cultural Classroom Communication
Authors: Nasution Liah Rosdiani 
Published: February 2021

Artikel ini bertujuan untuk menunjukkan pentingnya komunikasi lintas budaya di sekolah dan bagaimana komunikasi seperti ini tercermin dalam komunikasi dua mahasiswa internasional di kampus Amerika. Artikel ini juga mencoba untuk menunjukkan bagaimana konsep ABC tercermin dalam adaptasi internasional di ruang kelas Indonesia. Implikasi yang lebih besar dari temuan pada artikel ini diharapkan dapat membantu para guru di seluruh negeri untuk memberikan perhatian yang lebih besar pada penanaman strategi komunikasi lintas budaya yang lebih baik di ruang kelas mereka, baik di dalam kelas maupun di luar kelas.
Efeitos de práticas corporais no desenvolvimento motor em crianças e adolescentes com paralisia cerebral
Authors: Oliveira Miridan Rodrigues de , Nascimento Lucas Evangelista Campos do , Moraes Bruna Lethicia Jubé , Souza Wesley Salviano de , Pita Vinicius da Silva , Melo Geiziane Leite Rodrigues de , Mazzoccante Rafaello Pinheiro 
Published: February 2021

A paralisia cerebral é oriunda de lesões neurológicas com surgimentos em três diferentes condições, de acordo com a região neuroanatomica lesada, como espástica, atáxica e atetóide. Assim, crianças e adolescentes com paralisia cerebral possuem declínios no controle motor e na realização de movimentos voluntários, o grau de desempenho apresentado será intimamente relacionado a severidade da lesão cerebral. O objetivo desse estudo foi investigar por meio de uma revisão sistemática a influência de diferentes intervenções físicas e motoras no desenvolvimento motor de crianças e adolescentes com PC. Foi realizado uma busca por estudos em inglês e português produzidos de 2010 á 2020, nas bases de dados: Pubmed, Lilacs, Scielo, Elsevier e Pedro. Ao todo foram descritos 06 estudos. Todos os estudos demostram melhoras nas funções investigadas. Os achados expostos nos estudos encontrado nesta revisão, atestam que o efeito de práticas corporais de movimento corrobora de forma positiva no desenvolvimento motor de pacientes com paralisia cerebral. Sugere-se que possam ser realizados mais estudos que aborde não somente os métodos já apresentados, mas novas ferramentas que influencie para a melhora da coordenação motora e da qualidade de vida dos pacientes com paralisia cerebral em todos os seus tipos e topografias.
Comparison of the Efficacy of Glucagon-Like Peptide-1 Receptor Agonists in Patients With Metabolic Associated Fatty Liver Disease: Updated Systematic Review and Meta-Analysis
Authors: Dai Yuzhao , He He , Li Sheyu , Yang Lidan , Wang Xia , Liu Zhi , An Zhenmei 
Published: February 2021

AimsMetabolic associated fatty liver disease (MAFLD) is the most common cause of chronic liver disease and is a major health and economic burden in society. New drugs are urgently needed to treat MAFLD. This systematic review and meta-analysis was conducted to evaluate the efficacy of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in patients with MAFLD.MethodWe searched PubMed, Embase, Cochrane Library database, and Web of Science since 1977. We selected all randomized controlled trials which met the inclusion and exclusion criteria and evaluated the quality of evidence. A random-effects meta-analysis was performed to assess all the primary and second outcomes.ResultsEight randomized controlled trials, including 396 patients, of which 265 patients had type 2 diabetes mellitus, met the inclusion criteria. Compared with the placebo or active agents group, the GLP-RA group showed a significant reduction in the liver fat content [weight mean difference (WMD) -3.17%, 95%CI -5.30 to -1.03, P &lt; 0.0001], body weight (WMD -4.58 kg, 95%CI -8.07 to -1.10, P = 0.010), waist circumference (WMD -3.74 cm, 95%CI -6.73 to -0.74, P = 0.010), alanine aminotransferase (WMD -10.73 U/L, 95%CI -20.94 to -0.52, P = 0.04), γ- glutamyl transferase (WMD -12.25 U/L,95% -18.85 to -5.66, P = 0.0003, with I²=23%), fasting blood glucose (MD, -0.36 mmol/L; 95%CI, -0.69 to -0.03, P = 0.030), and hemoglobin A1c (WMD -0.36%, 95%CI -0.52 to -0.19, P &lt; 0.0001). The reported adverse events were gastrointestinal complications with no serious adverse events, and most symptoms were relieved within 1–2 weeks after dose titration.ConclusionGLP-RAs may improve liver injury and metabolic disorder in patients with MAFLD, regardless of the presence of type 2 diabetes mellitus. The benefits of GLP-RAs treatment outweigh the adverse effects of drugs in patients with MAFLD.
RETRACTED: Optimization of Pyrolysis Parameters for Production of Biochar From Banana Peels: Evaluation of Biochar Application on the Growth of Ipomoea aquatica
Authors: Te Wei Zun , Muhanin Kavinesh Nair Manor , Chu Yu-Ming , Selvarajoo Anurita , Singh Ajit , Ahmed Shams Forruque , Vo Dai-Viet N. , Show Pau Loke 
Published: February 2021

Banana peels waste can be utilized to produce high quality biochar that can be incorporated into the soil for sustainable production of crops. This research analyzed several properties of the biochar produced from the banana peel at different temperatures, residence times and heating rates. This study focuses on the biochar yield and the EDX analysis of the biochar produced. Response surface methodology using central composite design (CCD) was used to optimize these parameters in the batch reactor pyrolysis system. These factors were operated in different ranges for banana peels, in which pyrolysis temperature (200 to 600°C), residence time (60 to 180 min) and heating rate (5 to 15°C·min−1) were varied using 20 experiments respectively. Quality of the biochar was determined based on the biochar yield and O/C ratio. The optimum biochar chosen from the CCD model was applied to several pots of Ipomoea aquatica in different biochar dosage levels of 0, 3, 9 and 15 g (0, 1, 3 and 5 wt% of soil) respectively. Pot experiment was conducted with completely randomized design (CRD) of one factor with five replications to correlate the average plant heights with the biochar dosage levels. Results showed that biochar dosage of 1% yields the highest average final Ipomoea aquatica plant height of 37.04 cm.
Construction of Circular RNA–MicroRNA–Messenger RNA Regulatory Network of Recurrent Implantation Failure to Explore Its Potential Pathogenesis
Authors: Luo Jiahuan , Zhu Li , Zhou Ning , Zhang Yuanyuan , Zhang Lirong , Zhang Ruopeng 
Published: February 2021

Background: Many studies on circular RNAs (circRNAs) have recently been published. However, the function of circRNAs in recurrent implantation failure (RIF) is unknown and remains to be explored. This study aims to determine the regulatory mechanisms of circRNAs in RIF.Methods: Microarray data of RIF circRNA (GSE147442), microRNA (miRNA; GSE71332), and messenger RNA (mRNA; GSE103465) were downloaded from the Gene Expression Omnibus (GEO) database to identify differentially expressed circRNA, miRNA, and mRNA. The circRNA–miRNA–mRNA network was constructed by Cytoscape 3.8.0 software, then the protein–protein interaction (PPI) network was constructed by STRING database, and the hub genes were identified by cytoHubba plug-in. The circRNA–miRNA–hub gene regulatory subnetwork was formed to understand the regulatory axis of hub genes in RIF. Finally, the Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the hub genes were performed by clusterProfiler package of Rstudio software, and Reactome Functional Interaction (FI) plug-in was used for reactome analysis to comprehensively analyze the mechanism of hub genes in RIF.Results: A total of eight upregulated differentially expressed circRNAs (DECs), five downregulated DECs, 56 downregulated differentially expressed miRNAs (DEmiRs), 104 upregulated DEmiRs, 429 upregulated differentially expressed genes (DEGs), and 1,067 downregulated DEGs were identified regarding RIF. The miRNA response elements of 13 DECs were then predicted. Seven overlapping miRNAs were obtained by intersecting the predicted miRNA and DEmiRs. Then, 56 overlapping mRNAs were obtained by intersecting the predicted target mRNAs of seven miRNAs with 1,496 DEGs. The circRNA–miRNA–mRNA network and PPI network were constructed through six circRNAs, seven miRNAs, and 56 mRNAs; and four hub genes (YWHAZ, JAK2, MYH9, and RAP2C) were identified. The circRNA–miRNA–hub gene regulatory subnetwork with nine regulatory axes was formed in RIF. Functional enrichment analysis and reactome analysis showed that these four hub genes were closely related to the biological functions and pathways of RIF.Conclusion: The results of this study provide further understanding of the potential pathogenesis from the perspective of circRNA-related competitive endogenous RNA network in RIF.
Impact of an Intervention to Control Imipenem-Resistant Acinetobacter baumannii and Its Resistance Mechanisms: An 8-Year Survey
Authors: Chen Lida , Tan Pinghai , Zeng Jianming , Yu Xuegao , Cai Yimei , Liao Kang , Guo Penghao , Chen Yili , Wu Zongwen , Qu Pinghua , Cai Renxin , Chen Cha , Huang Bin 
Published: February 2021

BackgroundThis study aimed to examine the impact of an intervention carried out in 2011 to combat multi-drug resistance and outbreaks of imipenem-resistantAcinetobacter baumannii(IRAB), and to explore its resistance mechanism.MethodsA total of 2572 isolates ofA. baumannii, including 1673 IRAB isolates, were collected between 2007 and 2014. An intervention was implemented to controlA. baumanniiresistance and outbreaks. Antimicrobial susceptibility was tested by calculating minimal inhibitory concentrations (MICs), and outbreaks were typed using pulsed-field gel electrophoresis (PFGE). Resistance mechanisms were explored by polymerase chain reaction (PCR) and whole genome sequencing (WGS).ResultsFollowing the intervention in 2011, the resistance rates ofA. baumanniito almost all tested antibiotics decreased, from 85.3 to 72.6% for imipenem, 100 to 80.8% for ceftriaxone, and 45.0 to 6.9% for tigecycline. The intervention resulted in a decrease in the number (seven to five), duration (8–3 months), and departments (five to three) affected by outbreaks; no outbreaks occurred in 2011. After the intervention, onlyblaAMPC(76.47 to 100%) andblaTEM–1(75.74 to 96.92%) increased (P&lt; 0.0001); whereasblaGES–1(32.35 to 3.07%),blaPER–1(21.32 to 1.54%),blaOXA–58(60.29 to 1.54%),carO(37.50 to 7.69%), andadeB(9.56 to 3.08%) decreased (P&lt; 0.0001). Interestingly, the frequency of class B β-lactamase genes decreased from 91.18% (blaSPM–1) and 61.03% (blaIMP–1) to 0%, while that of class DblaOXA–23increased to 96.92% (P&lt; 0.0001). WGS showed that the major PFGE types causing outbreaks each year (type 01, 11, 18, 23, 26, and 31) carried the same resistance genes (blaKPC–1,blaADC–25,blaOXA–66, andadeABC), AdeR-S mutations (G186V and A136V), and a partially blocked porin channel CarO. Meanwhile, plasmids harboringblaOXA–23were found after the intervention.ConclusionThe intervention was highly effective in reducing multi-drug resistance ofA. baumanniiand IRAB outbreaks in the long term. The resistance mechanisms of IRAB may involve genes encoding β-lactamases, efflux pump overexpression, outer membrane porin blockade, and plasmids; in particular, clonal spread ofblaOXA–23was the major cause of outbreaks. Similar interventions may also help reduce bacterial resistance rates and outbreaks in other hospitals.
Wilms’ Tumor 1-Associated Protein Contributes to Chemo-Resistance to Cisplatin Through the Wnt/β-Catenin Pathway in Endometrial Cancer
Authors: Xie Wenli , Liu Naifu , Wang Xiangyu , Wei Ling , Xie Wenyan , Sheng Xiugui 
Published: February 2021

BackgroundCisplatin remains the mainstay of endometrial cancer (EC) chemotherapy. Wilms’ tumor 1-associated protein (WTAP), playing a critical role in transcriptional and post-transcriptional regulation, has been reported as an oncogene, and its expression is elevated in multiple types of human tumors. Recent evidence has shown that the increased expression of WTAP is also closely related to chemo-resistance. However, its specific role in the susceptibility of human EC cells to cisplatin remains largely unexplored.MethodsWTAP over-expression and WTAP depletion cell lines as well as their corresponding controls were constructed by transfection with lentivirus. Western blotting analysis and quantitative real-time polymerase chain reaction (qRT-PCR) were employed to detect the expression of WTAP. Cell proliferation assay, colony formation assay, cell cycle assay, and apoptosis analysis were adopted to evaluate the effect of WTAP on the chemo-sensitivity of EC cells to cisplatin as well as its underlying mechanism. Immunofluorescence staining was used to assess the translocation of β-catenin. Moreover, a subcutaneous xenograft tumor model was established to assess the effect of WTAP on tumor growth after cisplatin treatment.ResultsDepletion of WTAP in RL95-2 cells significantly enhanced the chemo-susceptibility of cells to cisplatin and increased the cell apoptosis, while WTAP over-expression in ARK-2 cells exhibited the opposite effects. Additionally, WTAP depletion significantly suppressed xenograft-tumor growth and enhanced sensitivity and apoptosis of tumor cells in vivo. Mechanistic analysis exhibited that WTAP over-expression facilitated the cytoplasm-to-nucleus translocation of β-catenin and enhanced the GSK3β phosphorylation at Ser9, while WTAP depletion revealed the opposite results, indicating that WTAP rendered chemo-resistance of EC cells to cisplatin by promoting the Wnt/β-catenin pathway.ConclusionsWTAP might promote the chemo-resistance of EC cells to cisplatin through activating the Wnt/β-catenin pathway. Collectively, our findings offered novel insights into EC treatment.
Chronic Metformin Therapy is Associated with a Lower Risk of Hemorrhoid in Patients with Type 2 Diabetes Mellitus
Authors: Tseng Chin-Hsiao 
Published: February 2021

Background: Metformin has anti-inflammatory property and reduces the risk of varicose vein in our previous study.Aim: To investigate the risk of hemorrhoid, another common disease involving the hemorrhoidal venous plexus, in ever vs. never users of metformin in patients with type 2 diabetes mellitus.Methods: This is a population-based retrospective cohort study. Patients with new-onset type 2 diabetes mellitus during 1999–2005 were enrolled from Taiwan’s National Health Insurance. All patients who were alive on January 1, 2006 were followed up until December 31, 2011. Analyses were conducted in both an unmatched cohort of 152,347 ever users and 19,523 never users and in 19,498 propensity score (PS)-matched pairs of ever and never users. Traditional Cox regression and Cox regression incorporated with the inverse probability of treatment weighting (IPTW) using the PS were used to estimate hazard ratios.Results: New-onset hemorrhoid was diagnosed in 8,211 ever users and 2025 never users in the unmatched cohort and in 1,089 ever users and 2022 never users in the matched cohort. The hazard ratio for ever vs. never users derived from the traditional Cox regression was 0.464 (95% confidence interval: 0.440–0.488) in the unmatched cohort; and was 0.488 (0.453–0.525) in the matched cohort. In the IPTW models, the hazard ratio was 0.464 (0.442–0.487) in the unmatched cohort and was 0.492 (0.457–0.530) in the matched cohort. A dose-response pattern was observed while comparing the tertiles of cumulative duration, cumulative dose and defined daily dose of metformin therapy to never users in all analyses. A risk reduction of approximately 40–50% was consistently observed in various sensitivity analyses.Conclusion: Chronic therapy with metformin in patients with type 2 diabetes mellitus is associated with a lower risk of hemorrhoid.
Borders as Crossroads: The Diverging Routes of Herbal Knowledge of Romanians Living on the Romanian and Ukrainian Sides of Bukovina
Authors: Mattalia Giulia , Stryamets Nataliya , Grygorovych Anya , Pieroni Andrea , Sõukand Renata 
Published: February 2021

Cross-border and cross-cultural ethnomedicine are novel ways to address the evolution of local ecological knowledge. As is widely acknowledged, ethnomedicinal knowledge is not static, but evolves according to several factors, including changes in ecological availability and socioeconomic conditions, and yet the effect of the political context on medicinal knowledge remains largely underexplored. Bukovina, a small region of Eastern Europe that has been divided by a border since the 1940s and is currently part of both Romania and Ukraine, represents a unique case study in which to address the impact of political contexts on ethnomedicinal knowledge. The aim of this study was to compare plant-based medicinal uses among Romanians living on the two sides of the Romanian–Ukrainian border. In addition, we performed cross-cultural and cross-border analysis with published data on the ethnomedicine of the neighboring ethnolinguistic group of Hutsuls. We conducted 59 semistructured interviews with conveniently selected Romanians living in both Romanian and Ukrainian Bukovina. We elicited preparations for treating different ailments and disorders by naming each part of the body. We also asked about the sources of this medicinal knowledge. We documented the medicinal use of 108 plant taxa belonging to 45 families. Fifty-four taxa were common to both Romanian communities; 20 were only found among Romanians living in Romania and 34 only among Romanians living in Ukraine. However, the number of recorded uses was higher among Romanians living in Romania, revealing that they make consistent use of local medicinal plants, and Romanians living in Ukrainian Bukovina use more taxa but less consistently. Comparison with the data published in our study on neighboring Hutsuls shows that medicinal knowledge is more homogeneous among Hutsuls and Romanians living in Ukraine, yet many similar uses were found among Romanian communities across the border. We argue that the 50 years during which Ukrainian Bukovina was part of the USSR resulted in the integration of standard pan-Soviet elements as evidenced by several plant uses common among the groups living in Ukraine yet not among Hutsuls and Romanians living in Romania.