bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of surgically diagnosed symptomatic endometriosis on women’s social lives, work and education: An inductive classical content analysis
Authors: Mastrangelo Melody , Turnbull Deborah 
Published: October 2021

Aims:The aim of this study is to extend understandings of the impact of surgically diagnosed endometriosis on women’s social lives, work and education.Methods:Participants (N = 200; average age: 27.1 years (±6.72)) were recruited from a range of sources, including social media and private women’s health clinics. They completed an online survey comprising seven open‐ended questions about how experience with endometriosis impacted (i) overall life; (ii) family relationships; (iii) friendships; (iv) attendance at social events; (v) engagement in leisure activities; (vi) work; and (vii) education. Data were analysed using inductive classical content analysis.Results:The data set contained 1400 discrete codable statements, with 19% of women reporting some form of social impact. A key result was the role of family and friends, both positive and negative, as well as the positive role that the workplace/educational institution can play (noted by 50% of participants). Findings highlight the negative impact on leisure activities, reported by 86% of women. The exhaustion of sick and unpaid leave was reported by 41% of women.Conclusion:This study highlights the impact of endometriosis on the social and economic lives of Australian women and underscores the importance of the comprehensive response recommended in the National Action Plan for Endometriosis.
Associations between aspirin prophylaxis and fetal growth and preeclampsia in women with pregestational diabetes
Authors: Shrestha Khatri Nely , White Scott W. , Graham Dorothy F. 
Published: October 2021

Background:Current guidelines recommend low‐dose aspirin for preeclampsia prophylaxis in all women with pregestational (type one and type two) diabetes mellitus. Most trials showing the efficacy of low‐dose aspirin in reducing preeclampsia risk have either excluded or included only small numbers of such women.Aim:To evaluate the association of low‐dose aspirin prophylaxis in women with pregestational diabetes with the incidence of large for gestational age (LGA) infants and preeclampsia.Materials and Methods:A retrospective observational study of pregnancies to women with pregestational diabetes. Outcomes included rates of LGA and preeclampsia. Women were prescribed low‐dose aspirin prophylaxis from early pregnancy according to physician discretion after considering preeclampsia risk. Statistical analyses assessed the group overall and with stratification by diabetes type and other preeclampsia risk factors.Results:Of 716 pregnancies, aspirin was prescribed in 296 (41%). Preeclampsia occurred more frequently in women who received aspirin (58 of 296, 20%) than those who did not (39 of 420, 9%, P < 0.001). This association was maintained after adjustment for diabetes type and other preeclampsia risk factors (adjusted odds ratio (aOR) 1.78; 95% CI 1.02–3.11). LGA infants were commoner in women with type one diabetes of short duration who took aspirin (aOR 2.21; 95% CI 1.05–4.66).Conclusion:Low‐dose aspirin use in women with pregestational diabetes may be associated with an increased risk of preeclampsia. In women with type one diabetes of short duration aspirin use may be associated with an increased risk of LGA infants. The retrospective nature of this study is acknowledged and assessment of such prophylaxis by further studies is warranted.
Defining the learning curve of transanal total mesorectal excision: a systematic review and meta‐analysis
Authors: Lau Steve Yee Chiang , Choy Kay Tai , Yang Tze Wei Wilson , Heriot Alexander , Warrier Satish K. , Guest Glenn D. , Kong Joseph C. 
Published: October 2021

AbstractBackgroundTransanal total mesorectal excision (taTME) represents a novel approach to rectal dissection. Although many structured training programs have been developed worldwide to assist surgeons in implementing this new technique, the learning curve (LC) of taTME has yet to be conclusively defined. This is particularly important given the concerns regarding the complication profile and oncological safety of taTME. The aim of this review was to provide an up‐to‐date systematic review and meta‐analysis of the LC for taTME, comparing the difference of outcomes between the LC and after learning curve (ALC) groups.MethodsAn up‐to‐date systematic review was performed on the available literature between 2010–2020 on PubMed, EMBASE, Medline and Cochrane Library databases. All studies comparing taTME procedures before and after LC were analysed.ResultsSeven retrospective studies of prospectively collected databases were included, comparing 333 (51.0%) patients in the LC group and 320 (49.0%) patients in the ALC group. There was a significantly reduced number of adverse intra‐operative events, anastomotic leaks and improved quality of mesorectal excision in the ALC group.ConclusionThis review shows that there is a significant improvement in clinical outcomes between the LC and ALC groups which supports the need for careful mastery and ongoing technical refinement during the LC in taTME. This procedure should be performed on a subset of carefully selected patients in the hands of experienced and well‐trained teams dedicated to ongoing audit.
Predictive factors for bleeding carotid artery pseudoaneurysms in patients with previous radiations for head and neck cancers
Authors: He Zhexi , Zhuang Tin Fong James , Ng Yuen Ting Rebecca , Cheng Horace , Tong Macy , Yu Chun Ho Simon , Wong George Kwok Chu 
Published: October 2021

AbstractBackgroundBleeding from carotid artery pseudoaneurysms is an emergency condition with high morbidity and mortality. We aimed to identify risk factors predicting pseudoaneurysmal bleeding as the cause of profuse epistaxis in irradiated head and neck cancer patients with suspect carotid blowout or pseudoaneurysms.MethodsWe retrospectively reviewed consecutive patients with history of radiation therapy for head and neck cancers and with nasal, oral or ear bleeding requiring in‐patient treatment from hospital database. Pseudoaneurysms were subgrouped into internal carotid artery (ICA) pseudoaneurysms, and external carotid artery (ECA) pseudoaneurysms. The treatment outcomes were evaluated using 30‐day mortality rate, recurrent bleeding, and cerebral infarction.ResultsThere were 41 admissions for suspected carotid blowout or pseudoaneurysms from 1 July 2016 to 30 June 2020 with 17 bleeding pseudoaneurysms identified, including 11 internal carotid arteries (ICA) pseudoaneurysms and 6 external carotid arteries (ECA) pseudoaneurysms. Among ICA pseudoaneurysms, six patients passed Balloon occlusion test with embolization and parent artery occlusion (trapping) of ICA performed, and all ECA pseudoaneurysms were embolized with parent artery occlusion (trapping). Baseline hypertension and hypotension on arrival were predictive for pseudoaneurysmal bleeding. The degree of haemoglobin drop was not significantly different between pseudoaneurysmal bleeding and non‐pseudoaneurysmal bleeding (2.1 ± 1.4 g/dL vs. 1.6 ± 1.4 g/dL, p = 0.234).ConclusionsWe identified baseline hypertension and hypotension on arrival as predictive factors for pseudoaneurysmal bleeding in patients with irradiated head and neck cancer. Presence of these risk factors should alert the clinicians to the possibility of carotid pseudoaneurysms.
In‐hospital survival after pancreatoduodenectomy is greater in high‐volume hospitals versus lower‐volume hospitals: a meta‐analysis
Authors: Kovoor Joshua G. , Ma Ning , Tivey David R. , Vandepeer Meegan , Jacobsen Jonathan Henry W. , Scarfe Anje , Vreugdenburg Thomas D. , Stretton Brandon , Edwards Suzanne , Babidge Wendy J. , Anthony Adrian A. , Padbury Robert T. A. , Maddern Guy J. 
Published: October 2021

AbstractBackgroundVariation in cut‐off values for what is considered a high volume (HV) hospital has made assessments of volume‐outcome relationships for pancreaticoduodenectomy (PD) challenging. Accordingly, we performed a systematic review and meta‐analysis comparing in‐hospital mortality after PD in hospitals above and below HV thresholds of various cut‐off values.MethodPubMed/MEDLINE, Embase and Cochrane Library were searched to 4 January 2021 for studies comparing in‐hospital mortality after PD in hospitals above and below defined HV thresholds. After data extraction, risk of bias was assessed using the Downs and Black checklist. A random‐effects model was used for meta‐analysis, including meta‐regressions. Registration: PROSPERO, CRD42021224432.ResultsFrom 1855 records, 17 observational studies of moderate quality were included. Median HV cut‐off was 25 PDs/year (IQR: 20–32). Overall relative risk of in‐hospital mortality was 0.37 (95% CI: 0.30, 0.45), that is, 63% less in HV hospitals. All subgroup analyses found an in‐hospital survival benefit in performing PDs at HV hospitals. Meta‐regressions from included studies found no statistically significant associations between relative risk of in‐hospital mortality and region (USA vs. non‐USA; p = 0.396); or 25th percentile (p = 0.231), median (p = 0.822) or 75th percentile (p = 0.469) HV cut‐off values. Significant inverse relationships were found between PD hospital volume and other outcomes.ConclusionIn‐hospital survival was significantly greater for patients undergoing PDs at HV hospitals, regardless of HV cut‐off value or region. Future research is required to investigate regions where low‐volume centres have specialized PD infrastructure and the potential impact on mortality.
Understanding the mechanism of retinal displacement following rhegmatogenous retinal detachment repair: A computer simulation model
Authors: Farahvash Armin , Marafon Samara B. , Juncal Verena R. , Figueiredo Natalia , Ramachandran Arun , Muni Rajeev H. 
Published: October 2021

AbstractPurposeRetinal displacement is common following rhegmatogenous retinal detachment (RRD) repair. A computer simulation was developed to assess forces applied by a gas tamponade of various sizes in the setting of pneumatic retinopexy (PnR) versus pars plana vitrectomy (PPV).DesignComputer simulation model.MethodsThe contact angle and pressure between the tamponade and the retina were calculated using interfacial tension and the densities of gas and vitreous. A simulation determined the dynamics of fluid motion in the subretinal space and calculated deformations of the retina.ResultsBulk flow of fluid away from the tamponade in a direction along gravity stretched the retina and caused displacement in the simulations. Extent of displacement is attributable to the subretinal fluid layer thickness, and area of contact and contact pressure applied by the tamponade. Larger gas tamponades have greater contact pressure applied to the retina. Reducing gas bubble size from 93% to 6.25% with PPV versus PnR, there was a 79% reduction in the mean contact pressure (1.4 mmHg–0.29 mmHg), and a 93% reduction in the surface area of contact (11 cm2–0.8 cm2). Therefore, the contact force applied to the entire retina decreases by 97% from 83 mN (PPV) to 2.9 mN (PnR). The model resembling PnR had more than three times less displacement compared to PPV.ConclusionsThis model provides a framework to study retinal displacement. Our findings suggest that proportional to their size, gas tamponades stretched the retina by displacing subretinal fluid following RRD repair.
The advantages of listening to academic content in a second language may be outweighed by disadvantages: A cognitive load theory approach
Authors: Roussel Stéphanie , Tricot André , Sweller John 
Published: October 2021

BackgroundIt is frequently implicitly assumed that advantages in language acquisition when learning content through a second language exceed the disadvantages of reduced content acquisition.AimsBased on cognitive load theory, that assumption was tested experimentally. The theory is concerned with techniques for reducing extraneous working memory load in order to facilitate learning.MaterialsThis study used a listening task.MethodsFrench students of Law and Political Science listened to an audio document about the European Court of Humans Rights under one of four experimental conditions: in their native language (French) twice; in a second language (German) twice; first in French, then in German; or first in German then in French. After the listening task, we tested students’ understanding of both the German language and of the academic content.ResultsOur results indicated that listening to the content in French before listening to it in a second language was beneficial for both content and language learning. In contrast, listening to content in a second language not only depressed content acquisition as is to be expected, but also depressed language acquisition. We discuss the relevance of cognitive load theory to frame learning tasks aimed at teaching content through a second language.
Do large losses loom larger than gains? Salience, holding periods, and the disposition effect
Authors: Kotomin Vladimir , Varma Abhishek 
Published: October 2021

AbstractIndividual investors are more likely to sell stocks with nominal gains and losses that are large relative to their brokerage portfolio value. The salience of nominal gains and losses affects stock sales in both taxable and tax‐deferred accounts and across investor groups, but the effect of nominal losses is weaker for stocks with high valuation uncertainty. The effect has a time dimension: at short holding periods, individuals are more likely to sell stocks with large nominal losses than gains of the same size, mitigating the disposition effect. Investors may be compelled to revisit their beliefs after incurring large losses quickly.
Safety and durability of cavo‐tricuspid isthmus linear ablation in the current era: Single‐center 9‐year experience from 1078 procedures
Authors: Kakehashi Shota , Miyazaki Shinsuke , Hasegawa Kanae , Nodera Minoru , Mukai Moe , Aoyama Daisetsu , Nagao Moeko , Sekihara Takayuki , Eguchi Tomoya , Yamaguchi Junya , Shiomi Yuichiro , Tama Naoto , Ikeda Hiroyuki , Ishida Kentaro , Uzui Hiroyasu , Tada Hiroshi 
Published: October 2021

AbstractBackgroundCavo‐tricuspid isthmus (CTI) linear ablation is performed not only for atrial flutter (AFL) but empirically during atrial fibrillation (AF) ablation in real‐world practice. PurposeWe sought to evaluate the safety and durability of the CTI ablation. MethodsThis retrospective study included 1078 consecutive patients who underwent a CTI ablation. AFL was documented before or during the procedure in 249 (23.1%) patients, and an empirical CTI and AF ablation were performed in 829 (76.9%) patients. ResultsCTI block was successfully created in 1051 (97.5%) patients with a 10.3 ± 6.6 min total radiofrequency time. Repeat procedures were performed for recurrent arrhythmias in 187 (17.3%) patients at a median of 11.0 (5.0–30.0) months postprocedure, and conduction resumption was identified in 68/174 (39.1%). Among those undergoing a CTI ablation with an AF ablation, the durability was significantly higher in those with than without documented AFL (78.1% vs. 58.2%, p = .031). The total radiofrequency time was significantly shorter (9.0 ± 5.3 vs. 10.0 ± 6.4 [mins], p = .024) and durability significantly higher (78.1 vs. 58.7[%], p = .043) in the large‐tip than irrigated‐tip catheter group. Iatrogenic AFL was observed after the empiric CTI ablation in 11 (1.3%) patients. Procedure‐related complications occurred in 15 (1.4%) patients. Eight patients experienced coronary artery spasms, including one with ventricular fibrillation following ST elevation on the ward. The other six patients experienced transient atrioventricular block and one experienced cardiac tamponade requiring drainage. ConclusionsDespite a high acute CTI ablation success, the conduction block durability was relatively low after the empiric ablation. An empiric CTI ablation at the time of the AF ablation is not recommended.
Association of glycated hemoglobin at an early stage of pregnancy with the risk of gestational diabetes mellitus among non‐diabetic women in Japan: The Japan Environment and Children’s Study
Authors: Sekine Tetsuo , Tsuchiya Kyoichiro , Uchinuma Hiroyuki , Horiuchi Sayaka , Kushima Megumi , Otawa Sanae , Yokomichi Hiroshi , Miyake Kunio , Akiyama Yuka , Ooka Tadao , Kojima Reiji , Shinohara Ryoji , Hirata Shuji , Yamagata Zentaro ,   The Japan Environment and Children’s Study Group
Published: October 2021

AbstractAims/IntroductionGestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and is associated with adverse pregnancy outcomes. This study aimed to explore the associations between glycated hemoglobin (HbA1c) levels at the early stage of pregnancy and the GDM risk among non‐diabetic women in a nationwide study in Japan. In addition, the relationship between GDM and adverse pregnancy outcomes was also analyzed.Materials and MethodsThis cohort study (n = 89,799) used data from the Japan Environment and Children’s Study. We stratified the participants into four groups according to HbA1c levels at an early stage of pregnancy. We investigated the association of HbA1c at an early stage of pregnancy with the risk of GDM, and of GDM with the risk of some representative adverse pregnancy outcomes, using the multiple logistic regression model with adjustment for potential confounders.ResultsThe adjusted odds ratio for GDM per 0.1 percentage point increase in HbA1c (%) was 1.20. The adjusted odds ratio for developing GDM was significantly increased in women from the HbA1c 5.0–5.4% category. GDM significantly increased the adjusted odds ratio for adverse pregnancy outcomes, such as hypertensive disorders of pregnancy, polyhydramnios and premature birth.ConclusionsHigh‐normal HbA1c levels at the early stage of pregnancy are significantly associated with GDM risk in women in Japan. GDM was significantly associated with adverse pregnancy outcomes.
Digestive proteinases from the marine fish processing wastes of the South‐West Atlantic Ocean: Their partial characterization and comparison
Authors: Friedman Ivana S. , Behrens Leonel A. , Pereira Nair de los Angeles , Contreras Edgardo M. , Fernández‐Gimenez Analia V. 
Published: October 2021

AbstractFish processing generates plenty of waste that is directly discarded in open‐air dumps and water sources, or treated in the same way as urban solid waste, causing serious pollution problems. The waste represents a significant source of high‐value bioproducts with potential applications in different industrial processes such as the production of feed, fertilizers, biodiesel and biogas, detergent additives and cosmetics. The objective of this study was to characterize and compare specific activities under different pH values and temperature conditions of acid and alkaline proteinases and viscera yield from the following fish species: Argentine hake Merluccius hubbsi, Brazilian flathead Percophis brasiliensis, Brazilian codling Urophycis brasiliensis and Stripped weakfish Cynoscion guatucupa. Individuals were fished off the coast of Mar del Plata (Argentina) by a commercial fleet and the viscera were immediately extracted and kept on ice until use. Stomach proteinases from four species had the highest activity at pH 2, with stability in the range of pH 2–4. The optimum pH was 11.5 from intestinal enzymes of C. guatucupa, M. hubbsi and P. brasiliensis and 9.5 from intestinal enzymes of U. brasiliensis. Alkaline proteinases from all species were highly stable in the range of 7–11.5. The optimum temperature of stomach proteinases from the four species studied were 30 and 50°C, with stability at 10 and 30°C during 150 min. The optimum temperature of intestinal enzymes from the tested species were 50°C with high stability at 10 and 30°C during 150 min. Alkaline proteinase from all species and acid proteinases from C. guatucupa were inactive at 70°C after 150 min, while there was a residual activity lower than 5% at 80°C on pre‐incubated stomach enzymes of M.hubbsi, P. brasiliensis and U. brasiliensis after 5, 10 and 20 min, respectively. Digestive proteinases recovered in this study could be appropriate for technological usage, reducing manufacturing costs, obtaining revenue from fishery wastes, and contributing to the reduction of environmental pollution.
Combination treatment for buttock and abdominal remodeling and skin improvement using HIFEM procedure and simultaneous delivery of radiofrequency and targeted pressure energy
Authors: Duncan Diane Irvine 
Published: October 2021

AbstractBackgroundHigh‐intensity electromagnetic field procedure (HIFEM) is an effective tool for body shaping and muscle toning. Radiofrequency (RF) combined with targeted pressure energy (TPE) provides the solution for skin laxity and cellulite.AimsTo document the effect of consecutive use of HIFEM, RF, and TPE for treatment of abdomen and buttocks.MethodsFifteen subjects (44.3 ± 14.2 years, 22.3 ± 2.3 kg/m2) finished treatments and consequent follow‐ups. They were treated over the abdomen (Group 1, N = 7) or buttocks (Group 2, N = 8), receiving four treatment procedures consisting of HIFEM treatment administered first, immediately followed by the simultaneous RF & TPE treatment. Each session took approximately 50 min (30 min of HIFEM; up to 20 min of RF & TPE) depending on the treated area. Study outcomes were assessed by the circumference measurement, satisfaction and comfort questionnaires, and digital photographs.ResultsCombined treatments were safe and comfortable. At 1 month, the abdominal circumference significantly decreased by 4.4 cm, while buttocks showed a significant increase by 1.0 cm. The abdomen (−4.1 cm) and buttocks (+1.2 cm) circumference results were sustained for three months without a significant decline. Satisfaction was high in both groups (93.3%) since most subjects noted that the appearance of the treated area has been improved, referring to both body sculpting and skin appearance.ConclusionsThe consecutive application of HIFEM, RF, and TPE treatments noticeably improved the appearance of the abdomen and buttocks. Subjects showed enhancement of abdominal body contour, buttock lifting, and improved skin quality manifested by reduced skin laxity and cellulite.