bluuebunny/crossref_metadata_2025_split huggingface dataset:
Handheld ECG Tracking of in-hOspital Atrial Fibrillation (HECTO-AF): A Randomized Controlled Trial
Authors: Mancinetti Marco , Schukraft Sara , Faucherre Yannick , Cook Stéphane , Arroyo Diego , Puricel Serban 
Published: May 2021

Background: Atrial fibrillation (AF) is frequent and causes substantial morbidity through AF-related strokes. Given the increasing prevalence of AF, screening methods are of interest given the potential to initiate timely appropriate anticoagulation.Aims: The HECTO-AF trial aims to determine the efficacy of AF screening with a single-lead electrocardiogram (ECG) handheld device in naïve in-hospital patients.Methods: The HECTO-AF is a single-center, open label, randomized controlled trial. Patients admitted to the general internal medicine ward of the University and Hospital Fribourg without previous diagnosis of AF were invited to participate in a screening program with a 1:1 allocation to either the screening group with intermittent single-lead handheld ECG recordings vs. a control group undergoing detection of AF as per routine clinical practice. The primary outcome was the prevalence of newly diagnosed AF during the hospital stay. Enrolment was terminated for poor patient recruitment and apparent futility before a sufficient sample for powered efficacy comparisons was enrolled.Results: A total of 804 patients were included of whom 381 were allocated to the intervention and 423 to the control group. Mean age was 65 ± 16 and 464 (58%) were male. Median CHA2DS2-VASc score was 3 (13% heart failure, 57% hypertension, 19% diabetes mellitus, 14% prior stroke/transient ischemic attack, and 29% arterial disease) and all CHA2DS2-VASc risk factors were equally distributed between groups. The incidence of newly detected AF was 1.4% over a median of 6 hospitalized days. Seven patients (1.8%) were diagnosed with AF in the intervention group vs. 3 (0.7%) in the control group (p = 0.20).Conclusion: There was a trend toward a higher AF detection over a median of 6 hospitalized days in the intervention group, but a definitive conclusion cannot be drawn due to the early termination of the present study. Systematic screening for AF in the hospital setting is resource-consuming, and of uncertain clinical benefit. The interpretation of single-lead handheld ECG is challenging and may result in inaccurate AF diagnosis.Clinical Trial Registration:ClinicalTrials.gov, identifier [NCT03197090].
Prevotella histicola Protects From Arthritis by Expansion of Allobaculum and Augmenting Butyrate Production in Humanized Mice
Authors: Balakrishnan Baskar , Luckey David , Bodhke Rahul , Chen Jun , Marietta Eric , Jeraldo Patricio , Murray Joseph , Taneja Veena 
Published: May 2021

Bacterial therapeutics are the emergent alternatives in treating autoimmune diseases such as Rheumatoid Arthritis [RA].P. histicolaMCI 001 is one such therapeutic bacterium that has been proven to treat autoimmune diseases such as RA and multiple sclerosis [MS] in animal models. The present study characterizedP. histicolaMCI 001 isolated from a human duodenal biopsy, and evaluated its impact on the gut microbial and metabolic profile in a longitudinal study using the collagen-induced arthritis model in HLA-DQ8.AEo transgenic mice.P. histicolaMCI 001 though closely related to the type strain ofP. histicola, DSM 19854, differed in utilizing glycerol. In culture,P. histicolaMCI 001 produced vitamins such as biotin and folate, and was involved in digesting complex carbohydrates and production of acetate. Colonization study showed that duodenum was the predominant niche for the gavaged MCI 001. A longitudinal follow-up of gut microbial profile in arthritic mice treated with MCI 001 suggested that dysbiosis caused due to arthritis was partially restored to the profile of naïve mice after treatment. A taxon-level analysis suggested an expansion of intestinal genusAllobaculumin MCI001 treated arthritic mice. Eubiosis achieved post treatment withP. histicolaMCI 001 was also reflected in the increased production of short-chain fatty acids [SCFAs]. Present study suggests that the treatment withP. histicolaMCI 001 leads to an expansion ofAllobaculumby increasing the availability of simple carbohydrates and acetate. Restoration of microbial profile and metabolites like butyrate induce immune and gut homeostasis.
Effects of Dynamic Hyperinflation on Left Ventricular Diastolic Function in Healthy Subjects — A Randomized Controlled Crossover Trial
Authors: Urban Matthias Helmut , Mayr Anna Katharina , Schmidt Ingrid , Grasmuk-Siegl Erwin , Burghuber Otto Chris , Funk Georg-Christian 
Published: May 2021

Objective:Diastolic dysfunction of the left ventricle is common in patients with chronic obstructive pulmonary disease (COPD). Dynamic hyperinflation has been suggested as a key determinant of reduced diastolic function in COPD. We aimed to investigate the effects of induced dynamic hyperinflation on left ventricular diastolic function in healthy subjects to exclude other confounding mechanisms associated with COPD.Design:In this randomized controlled crossover trial (NCT03500822,https://www.clinicaltrials.gov/), we induced dynamic hyperinflation using the validated method of expiratory resistance breathing (ERB), which combines tachypnea with expiratory resistance, and compared the results to those of tachypnea alone. Healthy male subjects (n= 14) were randomly assigned to the ERB or control group with subsequent crossover. Mild, moderate, and severe hyperinflation (i.e., ERB1, ERB2, ERB3) were confirmed by intrinsic positive end-expiratory pressure (PEEPi) using an esophageal balloon catheter. The effects on diastolic function of the left ventricle were measured by transthoracic echocardiographic assessment of the heart rate-adjusted transmitral E/A-ratio and E/e'-ratio.Results:We randomly assigned seven participants to the ERB group and seven to the control group (age 26 [24-26] vs. 24 [24-34],p= 0.81). Severe hyperinflation decreased the E/A-ratio compared to the control condition (1.63 [1.49–1.77] vs. 1.85 [0.95–2.75],p= 0.039), and moderate and severe ERB significantly increased the septal E/e'-ratio. No changes in diastolic function were found during mild hyperinflation. PEEPi levels during ERB were inversely correlated with the E/A ratio (regression coefficient = −0.007,p= 0.001).Conclusions:Our data indicate dynamic hyperinflation as a determinant of left ventricular diastolic dysfunction in healthy subjects. Therapeutic reduction of hyperinflation might be a treatable trait to improve diastolic function in patients with COPD.
Strict Surgical Repair for Bile Leakage Following the Roux-en-Y Hepaticojejunostomy
Authors: Zhang Keying , Wu Linfeng , Gao Kai , Yan Chengwei , Zheng Chao , Guo Chunbao 
Published: May 2021

Background: The optimal bile leakage management strategy in the pediatric population following the initial Roux-en-Y hepaticojejunostomy is still a matter of discussion today. Here, we assessed the roles of bile leakage management and surgical implementation on outcomes for patients with bile leakage.Materials and Methods: A revised protocol for bile leakage management with restricted surgical intervention was implemented at Chongqing Children’s Hospital on March 15, 2013 and Sanxia Hospital on April 20, 2013. We performed a retrospective, historical control analysis for the protocol implementation to compare the short- and long-term outcomes using the corresponding statistical methods.Results: There was a total of 84 patients included in the analysis, including 46 patients in the pre-protocol group and 38 patients in the post-protocol group. No statistical differences for the demographic features were found between the two groups. There was a decrease in redo surgeries in the post-protocol cohort compared to those in the pre-protocol cohort (odds ratio [OR] = 4.48 [95% CI, 1.57–12.77]; p = 0.003). Furthermore, patients in the post-protocol group were less likely to be associated with intensive care unit (ICU) admission (OR = 3.72 [95% CI, 1.11–12.49]; p = 0.024) compared to patients in the pre-protocol group, respectively. There was no mortality between the two groups.Conclusions: A restrictive surgical intervention strategy can effectively reduce the rate of redo surgery and exhibited promising outcomes for bile leakage in terms of postoperative recovery and hospitalization costs.
Analysis and Simulation of Epidemic COVID-19 Curves with the Verhulst Model Applied to Statistical Inhomogeneous Age Groups
Authors: Vandamme Lode K. J. , Rocha Paulo R. F. 
Published: May 2021

Pandemic curves, such as COVID-19, often show multiple and unpredictable contamination peaks, often called second, third and fourth waves, which are separated by wide plateaus. Here, by considering the statistical inhomogeneity of age groups, we show a quantitative understanding of the different behaviour rules to flatten a pandemic COVID-19 curve and concomitant multi-peak recurrence. The simulations are based on the Verhulst model with analytical generalized logistic equations for the limited growth. From the log–lin plot, we observe an early exponential growth proportional to et/τgrow. The first peak is often τgrow ≅ 5 d. The exponential growth is followed by a recovery phase with an exponential decay proportional to e−t/τrecov. For the characteristic time holds: τgrow< τrecov. Even with isolation, outbreaks due to returning travellers can result in a recurrence of multi-peaks visible on log–lin scales. The exponential growth for the first wave is faster than for the succeeding waves, with characteristic times, τ of about 10 d. Our analysis ascertains that isolation is an efficient method in preventing contamination and enables an improved strategy for scientists, governments and the general public to timely balance between medical burdens, mental health, socio-economic and educational interests.
Efficacy of Indole Acetic Acid and Exopolysaccharides-Producing Bacillus safensis Strain FN13 for Inducing Cd-Stress Tolerance and Plant Growth Promotion in Brassica juncea (L.)
Authors: Nazli Farheen , Wang Xiukang , Ahmad Maqshoof , Hussain Azhar , Bushra  , Dar Abubakar , Nasim Muhammad , Jamil Moazzam , Panpluem Nalun , Mustafa Adnan 
Published: May 2021

Untreated wastewater used for irrigating crops is the major source of toxic heavy metals and other pollutants in soils. These heavy metals affect plant growth and deteriorate the quality of edible parts of growing plants. Phytohormone (IAA) and exopolysaccharides (EPS) producing plant growth-promoting rhizobacteria can reduce the toxicity of metals by stabilizing them in soil. The present experiment was conducted to evaluate the IAA and EPS-producing rhizobacterial strains for improving growth, physiology, and antioxidant activity of Brassica juncea (L.) under Cd-stress. Results showed that Cd-stress significantly decreased the growth and physiological parameters of mustard plants. Inoculation with Cd-tolerant, IAA and EPS-producing rhizobacterial strains, however, significantly retrieved the inhibitory effects of Cd-stress on mustard growth, and physiology by up regulating antioxidant enzyme activities. Higher Cd accumulation and proline content was observed in the roots and shoot tissues upon Cd-stress in mustard plants while reduced proline and Cd accumulation was recorded upon rhizobacterial strains inoculation. Maximum decrease in proline contents (12.4%) and Cd concentration in root (26.9%) and shoot (29%) in comparison to control plants was observed due to inoculation with Bacillus safensis strain FN13. The activity of antioxidant enzymes was increased due to Cd-stress; however, the inoculation with Cd-tolerant, IAA-producing rhizobacterial strains showed a non-significant impact in the case of the activity of superoxide dismutase (SOD), peroxidase (POX) and catalase (CAT) in Brassica juncea (L.) plants under Cd-stress. Overall, Bacillus safensis strain FN13 was the most effective strain in improving the Brassica juncea (L.) growth and physiology under Cd-stress. It can be concluded, as the strain FN13 is a potential phytostabilizing biofertilizer for heavy metal contaminated soils, that it can be recommended to induce Cd-stress tolerance in crop plants.
Towards Understanding Relationships between Tension Property and Twinning Boundaries in Magnesium Alloy
Authors: Bai Jianhui , Yang Pengfei , Yang Zhiyuan , Sun Qi , Tan Li 
Published: May 2021

Although pre-induced {10 12¯} twins could strengthen magnesium and its alloys, the origin of such a strengthening phenomenon remains questionable. This is because twins can simultaneously change the size of grains and the texture features of the initial material. In the present work, the effect of pre-induced {101¯2} twins on the tension property of an extruded magnesium alloy has been investigated through a combination of electron backscatter diffraction, transmission electron microscope, and mechanical tests. Samples with and without {101¯2} twinning boundaries, but possessing an almost identical texture characteristic, were prepared by pre-compression perpendicular to the extrusion direction. Subsequently, these pre-strained samples were tensioned along the extrusion direction. The results indicate that the pre-induced {101¯2} twinning boundaries can indeed enhance the tension strength of magnesium alloys, but only slightly. The effect is closely associated with the amount of pre-strain. Correspondingly, the possible mechanisms behind such phenomena are given and discussed.
Effect of Extracts from Dominant Forest Floor Species of Clear-Cuts on the Regeneration and Initial Growth of Pinus sylvestris L. with Respect to Climate Change
Authors: Sirgedaitė-Šėžienė Vaida , Marčiulynas Adas , Baliuckas Virgilijus 
Published: May 2021

Climate change influences the ecological environment and affects the recruitment of plants, in addition to population dynamics, including Scots pine regeneration processes. Therefore, the impact of cover-dominant species extracts on the germination of pine seeds and morpho-physiological traits of seedling under different environmental conditions was evaluated. Increasing temperature reinforces the plant-donor allelochemical effect, reduces Scots pine seed germination, and inhibits seedling morpho-physiological parameters. Conditions unfavourable for the seed germination rate were observed in response to the effect of aqueous extracts of 2-year-old Vaccinium vitis-ideae and 1-year-old Calluna vulgaris under changing environmental conditions. The lowest radicle length and hypocotyl growth were observed in response to the effect of 1-year-old C. vulgaris and 2-year-old Rumex acetosella under increasing temperature (+4 °C) conditions. The chlorophyll a + b concentration in control seedlings strongly decreased from 0.76 to 0.66 mg g−1 (due to current environmental and changing environmental conditions). These factors may reduce the resistance of Scots pine to the effects of dominant species and affect the migration of Scots pine habitats to more favourable environmental conditions.
PROSPEK KEADILAN RESTORATIF DALAM PERATURAN PERUNDANG-UNDANGAN DI INDONESIA
Authors: Hanum Cholida 
Published: May 2021

This study aims to examine the concept of restorative justice from the point of view of Indonesian legislation. So far, studies on restorative justice have been limited to criminal law studies alone, so it is interesting to later portray restorative justice from a statutory perspective which is part of the study of constitutional law. Based on the author's investigation, the adoption of the concept of restorative justice in Indonesia is relatively new, which began after the DPR passed Law No. 11 of 2012 on an integrated criminal justice system. This law, although it was formed in 2012, came into effect two years later, namely in 2014. Restorative justice in the SPPA Law is enforced by a diversion method, namely the process of transferring children's cases from the judicial process to outside the court. There are at least two derivative regulations to carry out the mandate of the SPPA Law, first, the Supreme Court Regulation Number 4 of 2014 concerning Guidelines for the Implementation of Diversion in the Juvenile Justice System and second, the Republic of Indonesia Attorney's Regulation Number 15 of 2020 concerning Cessation of Prosecution Based on Restorative Justice.
Abstrak
Penelitian ini berusaha mengkaji konsepsi keadilan restoratif dalam sudut pandang peraturan perundang-undangan di Indonesia. Selama ini kajian mengenai keadilan restoratif terbatas pada kajian hukum pidana semata sehingga menarik untuk kemudian memotret keadilan restoratif dari perspektif perundang-undangan yang mana menjadi bagian dari kajian hukum tata negara. Berdasarkan penelusuran penulis, pengadopsian konsep keadilan restoratif di Indonesia terbilang baru yakni dimulai pasca DPR mensahkan Undang-undang Nomor 11 tahun 2012 tentang Sistem Peradilan pidana terpadu. Yang mana undang-undang ini meskipun dibentuk pada tahun 2012 namun mulai berlaku dua tahun kemudian yaitu pada tahun 2014. Keadilan restoratif dalam UU SPPA diberlakukan dengan metode diversi yaitu proses pengalihan perkara anak dari proses peradilan menjadi di luar peradilan. Setidaknya terdapat dua peraturan turunan guna melaksanakan amanah UU SPPA ini pertama, Peraturan Mahkamah Agung Nomor 4 Tahun 2014 tentang Pedoman Pelaksanaan Diversi dalam Sistem Peradilan Anak dan kedua, Peraturan Kejaksaan Republik Indonesia Nomor 15 tahun 2020 tentang Penghentian Penuntutan Berdasarkan Keadilan Restoratif.
KEDUDUKAN KEWARGANEGARAAN DJOKO CHANDRA DALAM ADMINISTRASI KEPENDUDUKAN DAN PEMBUATAN PASPOR REPUBLIK
Authors: Alamsyah Afif , Makarao Mohammad Taufik 
Published: May 2021

Djoko Tjandra involvement in corruption led him took an escape to Papuan New Guinea. During the search of Djoko Tjandra, police found new fact about Djoko Tjandra which said he gain new citizenship status from Papua New Guinea. According to Law No. 12/2006 about Indonesia Citizenship, Indonesia citizen will lose their citizenship status from Indonesia if they willing to accept another citizenship status from another country. Due to the loss of Djoko Citizenship status, government should act on this case. Government have the obligation to make sure that Djhoko does not receive any rights that belongs to Indonesia Citizen only, some of these rights are right to gain citizenship card and Indonesian passport.
Abstrak
Terjeratnya Djoko Tjandra dalam kasus tinda pidana korupsi membuatnya kabur dari Indonesia. Pada proses pencarian Djoko Tjandra, didapati bahwa ia mendapat status kewarganegaraan dari Papua Nugini. Berdasarkan UU No. 12 Tahun 2006 Tentang Kewarganegaraan Republik Indonesia dijelaskan bahwa seseorang akan kehilangan status kewarganegaraan Indonesia sesaat ia secara sukarela menerima status kewarganegaraan dari negara lain. Hilangnya status kewarganegaraan Djoko Tjandra harus ditindak tegas oleh negara. Negara harus memastikan bahwa Djoko Tjandra tidak mendapat hak yang hanya dimiliki oleh Warga Negara Indonesia, beberapa diantaranya adalah hak untuk mendapat KTP dan Paspor Indonesia.
STUDY ON CARDIOVASCULAR RISKS AND SERUM LEVELS OF NT-PROBNP IN&NBSP;
PATIENTS WITH PREECLAMPSIA
Authors: Nguyen Van Tri , Hoang Bui Bao , Huynh Van Minh 
Published: May 2021

Survey serum levels of NT-proBNP and cardiovascular risks in patients with preeclampsia. Methods: A descriptive cross-sectional study. A survey of 52 women with preeclampsia in the Department of Gynecology and Obstetrics - Hue Central Hospital, from August 2019 to September 2020. Results: In preeclampsia patients, the rate of grade 3 hypertension was 46.1%, of grade 2 hypertension was 32.7%, of grade 1 hypertension was 21.2%. The average Sokolow-Lyon index in preeclampsia group with and without severe features was respectively 22.25 ± 7.38mm; 20.16 ± 5.54mm, the average Sokolow-Lyon index were not significantly higher in severe features preeclampsia group compared with without severe features preeclampsia group. The average LVMI in patients with and without severe features preeclampsia was respectively 120.68 ± 16.47g/m2; 92.27 ± 14.56g/m2 and the average EF in patients with and without severe features preeclampsia was respectively 56.21 ± 7.12%; 65.11 ± 3.45%. The average LVMI and the average EF were significantly higher in severe features preclampsia group compared with without severe features preclampsia group (p < 0.05). In additon, the average serum levels of NT-proBNP in patients with preeclampsia were 598.22 ± 234.35pg/ml. Serum NT-proBNP levels were significantly higher in the severe features preeclampsia groups than in the without severe features group (p < 0.05). Conclusion: The NT-proBNP level were statiscally significantly increased in the patients with preeclampsia. Preeclampsia patients are at increased risks of cardivacular diseases later in life. The serum NT-proBNP level appears to be useful marker to evaluate long-term cardivascular risks.
Legal Framework to Protect the Rights of Migrant Workers: A Study with Reference to India
Authors: A Narayanaswamy 
Published: May 2021

In modern days right to life, freedom of profession and freedom of movement are recognised as a universal fundamental human rights, which are also interrelated and inter connected with each other. Universally, all human beings are equally entitled to enjoy all such rights. Indeed, migrant workers are also part of a human society who are not exceptional to enjoy all such rights. However, due to migration, migrant workers are marginalised and vulnerable groups. Perhaps, migrant workers are poor, illiterate and backward in all means. In this juncture, they have been exploited, discriminated and deprived to enjoy and access all such human rights equally compare to other non-migrant human beings across the globe. After the establishment of ILO and UNO, there are several International Declarations, Covenants and Conventional provisions etc.., which are equally applicable to all states across the globe including India to protect the rights of migrant workers. Similarly, in India also Constitutional provisions and legislative measures adopted, but due to failure to implement the above provisions effectively, migrant workers have been facing a lot of problems in inter-state and intra-state migration. Therefore, it is an attempt to know how for the rights of migrant workers have been safeguarded internationally and nationally. For this purpose the researcher has framed the following objectives.
Objectives
The Researcher has framed the following objectives,

To know the International legal frame work and how it protects the rights of migrant workers.
To examine the Indian legal system to protect the rights of migrant workers.
To know the causes, modes, problems and challenges of migrant workers.
Suitable suggestions to protect the rights of migrant workers.