bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asymptotic structure of the Rarita-Schwinger theory in four spacetime dimensions at spatial infinity
Authors: Fuentealba Oscar , Henneaux Marc , Majumdar Sucheta , Matulich Javier , Neogi Turmoli 
Published: February 2021

Abstract
We investigate the asymptotic structure of the free Rarita-Schwinger theory in four spacetime dimensions at spatial infinity in the Hamiltonian formalism. We impose boundary conditions for the spin-3/2 field that are invariant under an infinite-dimensional (abelian) algebra of non-trivial asymptotic fermionic symmetries. The compatibility of this set of boundary conditions with the invariance of the theory under Lorentz boosts requires the introduction of boundary degrees of freedom in the Hamiltonian action, along the lines of electromagnetism. These boundary degrees of freedom modify the symplectic structure by a surface contribution appearing in addition to the standard bulk piece. The Poincaré transformations have then well-defined (integrable, finite) canonical generators. Moreover, improper fermionic gauge symmetries, which are also well-defined canonical transformations, are further enlarged and turn out to be parametrized by two independent angle-dependent spinor functions at infinity, which lead to an infinite-dimensional fermionic algebra endowed with a central charge. We extend next the analysis to the supersymmetric spin-(1, 3/2) and spin-(2, 3/2) multiplets. First, we present the canonical realization of the super-Poincaré algebra on the spin-(1, 3/2) multiplet, which is shown to be consistently enhanced by the infinite-dimensional abelian algebra of angle-dependent bosonic and fermionic improper gauge symmetries associated with the electromagnetic and the Rarita-Schwinger fields, respectively. A similar analysis of the spin-(2, 3/2) multiplet is then carried out to obtain the canonical realization of the super-Poincaré algebra, consistently enhanced by the abelian improper bosonic gauge transformations of the spin-2 field (BMS supertranslations) and the abelian improper fermionic gauge transformations of the spin-3/2 field.
Is it good to be bad or bad to be good? Assessing the aggregate impact of abnormal weather on consumer spending
Authors: Sandqvist Anna Pauliina , Siliverstovs Boriss 
Published: February 2021

AbstractAlthough the influence of exceptional weather on individual behaviour has already been acknowledged in finance, psychology, and marketing, the literature examining weather effects at more aggregate level is still limited. Further, there is a lot of anecdotal evidence that weather anomalies affect consumer spending and retail business. The main aim of this analysis is to investigate and quantify the effects of unusual weather in consumer spending at macro-level. Using aggregate retail sales data for Switzerland, our findings reveal that weather deviations from seasonal norms, especially, unusually high or low temperatures in a given month, do cause sizeable intertemporal shifts in consumer spending at country level. Furthermore, the effects of abnormal weather are found to differ across seasons, both with respect to sign and magnitude. In particular, our findings indicate that weather effects manifest mainly through the seasons change channel: weather conditions in line with the coming season boost the purchases early in the season.
Mast cell proliferation in the cerebrospinal fluid after intraventricular administration of anti-B7H3 immunotherapy
Authors: Kramer Kim , Donzelli Maria A. , Pessin Melissa S. 
Published: February 2021

AbstractOmburtamab is a B7H3-specific murine monoclonal antibody. B7H3 (CD 276) is a member of the B7 family of immune checkpoint co-inhibitory receptors overexpressed on many human malignancies. Radioimmunotherapy with 124I- or 131I-omburtamab administered in the cerebrospinal fluid (CSF), intraperitoneal or intratumoral cavity is currently under investigation for the treatment of CNS malignancies. The immunologic effects of anti-B7H3 therapy are not fully elucidated. A 6-year-old male was diagnosed with metastates of neuroblastoma to the received intraventricular 131I-omburtamab on an IRB-approved protocol. A treatment cycle consisted of a 2 mCi dosimetry dose and a 50 mCi treatment dose. Dosimetry by serial imaging, pharmacokinetics and safety were investigated. Clinical status, magnetic resonance imaging, CSF cell count and cytology were evaluated pre- and post-131I-omburtamab at 5 and 26 weeks. The patient did well with cycle 1. Three hours after the dosimetry dose of cycle 2, he developed a fever (39 °C), chills and headache. Blood and CSF samples were sent for culture. CSF was notable for nucleated cell pleocytosis with profound mast cell proliferation consistent with chemical meningitis. He was treated with supportive care; symptoms resolved over 48 h. Further therapy with 131I-omburtamab was electively discontinued. CSF cell count 5 weeks later demonstrated resolution of CSF pleocytosis. Local–regional administration of intraventricular 131I-omburtamab targeting B7H3 can result in a profound nucleated CSF pleocytosis with mastocytosis consistent with an acute allergic reaction.
Historical Observations on Clamshell Thoracotomy
Authors: Ehrhardt John D. , Baroutjian Amanda , McKenney Mark , Elkbuli Adel 
Published: February 2021

AbstractBilateral transverse thoracosternotomy, known colloquially as “clamshell thoracotomy,” provides quick and extensive exposure to the thoracic organs. The origins of the radical incision are unclear, and its influence on historical developments in surgery has not been elaborated. Transsternal extension to bilateral thoracotomy likely occurred during World War I and was designated as Tuffier's method by 1922. Théodore Tuffier had already solidified his reputation as a trailblazing thoracic surgeon in Paris when the French army summoned him to design triage systems for trauma patients during the Great War. Following World War II, cardiac surgery grew tremendously during the 1950s, and many pioneering open‐heart procedures utilized the bilateral incision for safe exposures with satisfactory results. Median sternotomy became the incision of choice for open‐heart surgery by the early 1960s; however, thoracotomy remained important to the trauma surgeon's repertoire. Transsternal conversion was only briefly mentioned in trauma literature through the 1980s, although up to one‐half of reported emergency thoracotomies at busy trauma centers were clamshells. The moniker clamshell thoracotomy came in 1994 when thoracic surgical oncology and lung transplantation flourished with complex operations requiring larger incisions. The twenty‐first century has brought two iterations of evidence‐based guidelines for emergency thoracotomy, but incision choice has not been formally discussed. Renewed conversation in recent years has advocated for the clamshell as arguably the best approach for patients in extremis. Given these trends, the tortuous history of this controversial incision deserves attention.
Thymus and autoimmunity
Authors: Marx Alexander , Yamada Yosuke , Simon-Keller Katja , Schalke Berthold , Willcox Nick , Ströbel Philipp , Weis Cleo-Aron 
Published: February 2021

AbstractThe thymus prevents autoimmune diseases through mechanisms that operate in the cortex and medulla, comprising positive and negative selection and the generation of regulatory T-cells (Tregs). Egress from the thymus through the perivascular space (PVS) to the blood is another possible checkpoint, as shown by some autoimmune/immunodeficiency syndromes. In polygenic autoimmune diseases, subtle thymic dysfunctions may compound genetic, hormonal and environmental cues. Here, we cover (a) tolerance-inducing cell types, whether thymic epithelial or tuft cells, or dendritic, B- or thymic myoid cells; (b) tolerance-inducing mechanisms and their failure in relation to thymic anatomic compartments, and with special emphasis on human monogenic and polygenic autoimmune diseases and the related thymic pathologies, if known; (c) polymorphisms and mutations of tolerance-related genes with an impact on positive selection (e.g. the gene encoding the thymoproteasome-specific subunit,PSMB11), promiscuous gene expression (e.g.AIRE,PRKDC,FEZF2,CHD4), Treg development (e.g.SATB1,FOXP3), T-cell migration (e.g.TAGAP) and egress from the thymus (e.g.MTS1,CORO1A); (d) myasthenia gravis as the prototypic outcome of an inflamed or disordered neoplastic ‘sick thymus’.
Regulation of retinal membrane guanylyl cyclase (RetGC) by negative calcium feedback and RD3 protein
Authors: Dizhoor Alexander M. , Peshenko Igor V. 
Published: February 2021

AbstractThis article presents a brief overview of the main biochemical and cellular processes involved in regulation of cyclic GMP production in photoreceptors. The main focus is on how the fluctuations of free calcium concentrations in photoreceptors between light and dark regulate the activity of retinal membrane guanylyl cyclase (RetGC) via calcium sensor proteins. The emphasis of the review is on the structure of RetGC and guanylyl cyclase activating proteins (GCAPs) in relation to their functional role in photoreceptors and congenital diseases of photoreceptors. In addition to that, the structure and function of retinal degeneration-3 protein (RD3), which regulates RetGC in a calcium-independent manner, is discussed in detail in connections with its role in photoreceptor biology and inherited retinal blindness.
Use of self-expandable metallic stents for endoscopic biliary decompression decreases stent complications in pancreatic cancer patients receiving chemotherapy
Authors: Vehviläinen Sini , Seppänen Hanna , Nurmi Anna , Haglund Caj , Mustonen Harri , Udd Marianne , Kylänpää Leena 
Published: February 2021

Abstract
Background
Both plastic stents and self-expandable metallic stents (SEMSes) are used for endoscopic biliary decompression (BD) among patients with pancreatic cancer (PAC). Cholangitis or stent occlusion often interrupts or ends chemotherapy. We investigated cholangitis, stent occlusion, and chemotherapy interruption rates for SEMSes and plastic stents among patients receiving chemotherapy for PAC.

Materials and methods
We retrospectively analyzed data for 293 PAC patients who received a biliary stent at Helsinki University Hospital during 2000–2017. Patients received chemotherapy as palliative treatment (PT: n = 187) or neoadjuvant treatment (NAT: n = 106). Among participants, 229 had a plastic stent (PT: n = 138, NAT: n = 91) and 64 had a SEMS (PT: n = 49, NAT: n = 15).

Results
Overall, 15.6% (n = 10) of patients with SEMSes (PT: 20.4%, n = 10, NAT: 0%) and 53.0% (n = 121) of patients with plastic stents (PT: 69.3%, n = 95, NAT: 28.5%, n = 26) experienced one or more stent complications (p < 0.001). Cholangitis developed in 6.3% (n = 8) of PT patients with SEMSes. No patients with SEMSes receiving NAT (n = 15) experienced cholangitis. However, 31.9% (PT: 42.8%, n = 59, p = 0.001; NAT: 15.4%, n = 14, p = 0.211) of patients with plastic stents developed cholangitis. Among all patients receiving NAT or PT, cholangitis interrupted chemotherapy 6 times (9.4%) in SEMS patients and 61 times (26.6%) in plastic stent patients (p = 0.004). Stent occlusion without cholangitis interrupted NAT or PT 2 times (2.1%) in SEMS patients and 31 times (13.5%) in plastic stent patients (p = 0.023).

Conclusions
SEMS is recommended for BD among patients with PAC receiving chemotherapy. Among both PT and NAT patients, patients with SEMS experience a lower stent failure rate, lower rate of cholangitis, and fewer chemotherapy interruptions than patients with plastic stents.
Minimally invasive distal pancreatectomy: a case-matched cost-analysis between robot-assisted surgery and direct manual laparoscopy
Authors: Di Franco Gregorio , Peri Andrea , Lorenzoni Valentina , Palmeri Matteo , Furbetta Niccolò , Guadagni Simone , Gianardi Desirée , Bianchini Matteo , Pollina Luca Emanuele , Melfi Franca , Mamone Domenica , Milli Carlo , Di Candio Giulio , Turchetti Giuseppe , Pietrabissa Andrea , Morelli Luca 
Published: February 2021

Abstract
Background
Few studies have reported a structured cost analysis of robotic distal pancreatectomy (RDP), and none have compared the relative costs between the robotic-assisted surgery (RAS) and the direct manual laparoscopy (DML) in this setting. The aim of the present study is to address this issue by comparing surgical outcomes and costs of RDP and laparoscopic distal pancreatectomies (LDP).

Methods
Eighty-eight RDP and 47 LDP performed between January 2008 and January 2020 were retrospectively analyzed. Three comparable groups of 35 patients each (Si-RDP-group, Xi-RDP group, LDP-group) were obtained matching 1:1 the RDP-groups with the LDP-group. Overall costs, including overall variable costs (OVC) and fixed costs were compared using generalized linear regression model adjusting for covariates.

Results
The conversion rate was significantly lower in the Si-RDP-group and Xi-RDP-group: 2.9% and 0%, respectively, versus 14.3% in the LDP-group (p = 0.045). Although not statistically significant, the mean operative time was lower in Xi-RDP-group: 226 min versus 262 min for Si-RDP-group and 247 min for LDP-group. The overall post-operative complications rate and the length of hospital stay (LOS) were not significantly different between the three groups. In LDP-group, the LOS of converted cases was significantly longer: 15.6 versus 9.8 days (p = 0.039). Overall costs of LDP-group were significantly lower than RDP-groups, (p < 0.001). At multivariate analysis OVC resulted no longer statistically significantly different between LDP-group and Xi-RDP-group (p = 0.099), and between LDP-group and the RDP-groups when the spleen preservation was indicated (p = 0.115 and p = 0.261 for Si-RDP-group and Xi-RDP-group, respectively).

Conclusions
RAS is more expensive than DML for DP because of higher acquisition and maintenance costs. The flattening of these differences considering only the variable costs, in a high-volume multidisciplinary center for RAS, suggests a possible optimization of the costs in this setting. RAS might be particularly indicated for minimally invasive DP when the spleen preservation is scheduled.
Moving far, staying close: red fox dispersal patterns revealed by SNP genotyping
Authors: Walton Zea , Hagenlund Mari , Østbye Kjartan , Samelius Gustaf , Odden Morten , Norman Anita , Willebrand Tomas , Spong Göran 
Published: February 2021

AbstractThe genetic structure of a population can provide important insights into animal movements at varying geographical scales. Individual and social behaviors, such as philopatry and dispersal, affect patterns of relatedness, age and sex structure, shaping the local genetic structure of populations. However, these fine scale patterns may not be detected within broader population genetic structure. Using SNP genotyping for pairwise relatedness estimates, we investigated the spatial and genetic structuring of 141 red foxes within south-central Sweden at two scales. First, we looked at broad scale population structuring among red foxes at the regional level. We then estimated pairwise relatedness values to evaluate the spatial and genetic structure of male, female and mixed sex pairs for patterns of philopatry and dispersal at a more localized scale. We found limited genetic differentiation at the regional scale. However, local investigations revealed patterns of female philopatry and male biased dispersal. There were significant differences in pairwise geographic distances between highly related same sex pairs with the average distance between related males, 37.8 km, being six times farther than that of related females, averaging 6.3 km. In summary, the low levels of genetic differentiation found in this study illustrates the mobility and dispersal ability of red foxes across scales. However, relatedness plays a strong role in the spatial organization of red foxes locally, ultimately contributing to male biased dispersal patterns.
Inferentialist Truth Pluralism
Authors: Veluwenkamp Herman 
Published: February 2021

AbstractMetasemantic inferentialismhas gained popularity in the last few decades. Traditionally, inferentialism is combined with a deflationary attitude towards semantic terms such as truth and reference, i.e., many inferentialists hold that when we use these semantic terms we do not purport to refer to substantive properties. This combination makes inferentialism attractive for philosophers who see themselves as antirealists. Although the attractions of combining inferentialism and deflationism are easy to see, deflationism is also a controversial position. For one, deflationists maintain that truth is an insubstantive property, but it is not altogether clear what an insubstantive property is. Secondly, as deflationists maintain that truth does not play an explanatory role, it is incompatible with the position that truth can explain the normativity of truth talk. Given that deflationism faces these objections, it would be preferable if the success of inferentialism did not depend on the deflationist’s ability to respond to these objections. I argue that someone attracted to inferentialism for its ability to accommodate antirealist intuitions about a domain (e.g. morality) is not committed to deflationism about truth. More specifically, I will show that inferentialism combined with a straightforward account of inferentialist truth-conditions is compatible with a version of truth pluralism. I call this position Inferentialist Truth Pluralism.
Sonographic abnormalities in pregnancies conceived following IVF with and without preimplantation genetic testing for aneuploidy (PGT-A)
Authors: Riestenberg Carrie K. , Mok Thalia , Ong Jessica R. , Platt Lawrence D. , Han Christina S. , Quinn Molly M. 
Published: February 2021

AbstractPurposeTo report the rate of fetal anomalies detected on anatomy ultrasound in pregnant patients who underwent IVF with preimplantation genetic testing for aneuploidy (PGT-A) compared to patients who conceived following IVF with unscreened embryos and age-matched patients with natural conceptions.MethodsRetrospective cohort study at a single maternal-fetal medicine practice. Patients with singleton pregnancies who had a mid-trimester anatomy ultrasound between January 2017 and December 2018 were screened for inclusion. A total of 712 patients who conceived after IVF with or without PGT-A were age-matched with natural conception controls. The primary outcome was the rate of fetal and placental anomalies detected on mid-trimester anatomical survey. Secondary outcomes included the rates of abnormal nuchal translucency (NT), second trimester serum analytes, non-invasive prenatal testing (NIPT), and invasive diagnostic testing.Result(s)There were no differences in the rate of fetal anomalies in patients who underwent IVF with PGT-A compared to patients who conceived following IVF with unscreened embryos and age-matched patients with natural conceptions. Rate of abnormal NT, high-risk NIPT, and abnormal invasive diagnostic testing were also similar. Patients who conceived after IVF with or without PGT-A had higher rates of abnormal placental ultrasound findings and abnormal second trimester serum analytes compared to natural conception controls.ConclusionThe use of PGT-A was not associated with a difference in risk of fetal anomaly detection on a mid-trimester anatomical survey. The results of this study highlight the importance of improved patient counseling regarding the limitations of PGT-A, and of providing standard prenatal care for pregnancies conceived through ART, regardless of whether PGT-A was performed.
Gold nanoparticles obtained by ns-pulsed laser ablation in liquids (ns-PLAL) are arranged in the form of fractal clusters
Authors: Gentile Luigi , Mateos Helena , Mallardi Antonia , Dell’Aglio Marcella , De Giacomo Alessandro , Cioffi Nicola , Palazzo Gerardo 
Published: February 2021

AbstractGold nanoparticles (AuNPs), synthesized by ns-pulsed laser ablation in liquid (ns-PLAL) in the absence of any capping agents, are potential model systems to study the interactions with biological structures unencumbered by interference from the presence of stabilizers and capping agents. However, several aspects of the physics behind these AuNPs solutions deserve a detailed investigation. The structure in solution of ns-PLAL-synthesized AuNPs was investigated in solution by means of small-angle X-ray scattering (SAXS) and dynamic light scattering (DLS). Furthermore, the (dried) NPs have been examined using TEM. The analysis of the SAXS curve shows the presence of a large number of small aggregates with a fractal structure stabilized by strong long-range repulsive interactions. Fitting of the SAXS curve to a suitable “fractal model” allows the estimation of the features of the fractal including the fractal dimension d = 1.9. The latter allows to estimate the fraction of light scattered by fractals of different sizes and thus permits a fair comparison between the DLS and TEM data. Here, a stable abundant population of fractal clusters is reported reflecting a mechanism where primary AuNPs (size 7.6 nm) are forced to aggregate forming clusters during the collapse of the cavitation bubble. When these clusters are released in the aqueous phase, their large negative charge builds up repulsive interactions that prevent cluster-cluster aggregation imparting colloidal stability.
Bootstrapping of integer concepts: the stronger deviant-interpretation challenge (and how to solve it)
Authors: Pantsar Markus 
Published: February 2021

AbstractBeck (Cognition 158:110–121, 2017) presents an outline of the procedure of bootstrapping of integer concepts, with the purpose of explicating the account of Carey (The Origin of Concepts, 2009). According to that theory, integer concepts are acquired through a process of inductive and analogous reasoning based on the object tracking system (OTS), which allows individuating objects in a parallel fashion. Discussing the bootstrapping theory, Beck dismisses what he calls the "deviant-interpretation challenge"—the possibility that the bootstrapped integer sequence does not follow a linear progression after some point—as being general to any account of inductive learning. While the account of Carey and Beck focuses on the OTS, in this paper I want to reconsider the importance of another empirically well-established cognitive core system for treating numerosities, namely the approximate number system (ANS). Since the ANS-based account offers a potential alternative for integer concept acquisition, I show that it provides a good reason to revisit the deviant-interpretation challenge. Finally, I will present a hybrid OTS-ANS model as the foundation of integer concept acquisition and the framework of enculturation as a solution to the challenge.
Körperorientierte Intervention im Coaching
Authors: Lienhard Natascha , Künzli Hansjörg 
Published: February 2021

ZusammenfassungIn der Coaching-Literatur sind körperorientierte Interventionen untervertreten oder haben nicht den Stellenwert, der ihnen zukommen könnte. Zu der Frage, ob und in welchem Ausmaß sich dies auch in der Coachingpraxis spiegelt, führten wir im Herbst 2020 eine Online-Umfrage durch. Insgesamt 242 Coaches beantworteten 45 Fragen zu vier Themenkreisen körperorientierter Interventionen. Die meisten der befragten Coaches setzen körperorientierte Interventionen ein, betrachten sie als zielführend und sinnvoll für Coaching und wollen sie in Zukunft gleich oft oder noch intensiver einzusetzen. Große Unterschiede sind festzustellen hinsichtlich der Art der eingesetzten Interventionen. Körperhaltung und Mimik wird von fast allen Coaches als Erkenntnisquelle genutzt. Die aktive Arbeit mit dem Körper, z. B. in Form von Bewegungsübungen, wird weniger oft eingesetzt. Das Thema Körperorientierte Intervention im Coaching ist noch weitgehend unerforscht. Ebenso entsteht der Eindruck, dass der Begriff „körperorientierte Intervention“ im Coaching noch sehr unterschiedlich gedeutet wird.