bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic value of preoperative inflammation markers in non‐muscle invasive bladder cancer
Authors: Yıldız Hüseyin Alperen , Değer Müslim Doğan , Aslan Güven 
Published: February 2021

AbstractPurposeTo investigate the prediction values of the preoperative neutrophil‐lymphocyte ratio (NLR), lymphocyte‐monocyte ratio (LMR), platelet‐lymphocyte ratio (PLR), mean platelet volume (MPV) and red cell distribution width (RDW) for recurrence and progression of patients with non‐muscle invasive bladder cancer (NMIBC).MethodsIn this prospective study, 94 consecutive patients newly diagnosed with NMIBC between July 2017 and August 2018 were included. The blood samples were collected from patients before transurethral resection of bladder tumour (TURB) and NLR, LMR, PLR, RDW and MPV values were calculated. The effect of these preoperative inflammatory parameters and other clinicopathological parameters on recurrence and progression rates was evaluated. Kaplan–Meier and multivariate Cox regression analyses were performed to identify significant prognostic variables.ResultsThe mean follow‐up was 11 ± 6.4 months. Recurrence was observed in 35.1% and progression was detected in 7.4% of the patients. NLR was statistically significantly associated with both recurrence (P = .01) and progression (P = .035), whereas LMR was only associated with recurrence (P = .038). In the survival analyses, the relationship between recurrence and LMR was confirmed in both univariate (P = .021) and multivariate (P = .022) analyses. The relationship between NLR and recurrence was confirmed in univariate analysis (P = .019); however; in multivariate analysis, it was found to be statistically insignificant (P = .051).ConclusionsLMR might be an easy obtainable, non‐invasive and cost‐effective method for predicting recurrence of disease in patients with NMIBC.
Effect of liraglutide treatment on body mass index and weight parameters in children and adolescents with type 2 diabetes: Post hoc analysis of the ellipse trial
Authors: Bensignor Megan O. , Bomberg Eric M. , Bramante Carolyn T. , Divyalasya T. V. S. , Hale Paula M. , Ramesh Chethana K. , Rudser Kyle D. , Kelly Aaron S. 
Published: February 2021

SummaryBackgroundWeight loss in children and adolescents with type 2 diabetes (T2D) is associated with improved glycaemic control.ObjectivesTo assess the effects of liraglutide vs placebo on body mass index (BMI) and weight parameters in children and adolescents with T2D using data from the ellipse trial (NCT01541215).MethodsThe ellipse trial randomized participants (10‐<17 years old, BMI >85th percentile, T2D, glycated haemoglobin [HbA1c] 7.0%‐11.0% [if diet‐ and exercise‐treated] or 6.5% to 11.0% [if treated with metformin, basal insulin or both]) to liraglutide or placebo. This post‐hoc analysis evaluated changes from baseline to weeks 26 and 52 in absolute BMI, percent change in BMI and other weight‐related parameters. Changes were assessed by liraglutide overall (all doses) and liraglutide by dose (0.6, 1.2 and 1.8 mg/day) vs placebo using a pattern mixture model of observed data, with missing observations imputed from each treatment group.ResultsIn total, 134 participants were included. There were statistically significant differences between groups in certain parameters, including absolute BMI (estimated treatment difference [ETD] –0.89 kg/m2; 95% confidence interval [CI] –1.71,–0.06) and percent change in BMI (ETD –2.73%; 95% CI –5.15,–0.30) at week 52, but none at week 26. Dose‐dependent effects were not observed for liraglutide vs placebo for all BMI/weight parameters.ConclusionsCompared with placebo, liraglutide was associated with statistically significant reductions in BMI/weight parameters at week 52, but not week 26, in children and adolescents with T2D.
Managerial Jacobinism and performance in the private sector: Evidence from the Turkish shipyards for a vertical frame
Authors: Cam Surhan , Palaz Serap 
Published: February 2021

AbstractLong‐lasting euphoria of the private sector managerialism has begun to be questioned even by its ardent advocators in recent years. Substantiating a distinct concern, this paper sheds light on what one might call ‘managerial Jacobinism’ through unstructured interviews conducted in Turkey's shipyards. As its most defining characteristics, the undervaluation of managerial work by the companies and the punitive treatment of good practices by the mediocre superiors provoke ill‐concealed defensive reactions among the managers to their insecurity at work while undermining both employees' productivity and the firms' performance in the midst of regulatory deficiencies. Managerial Jacobinism also spirals around a vertical frame by being more apparent and survival‐driven in the case of immediate managers whereas more ambition‐driven and detrimental when it comes to top managers resonating with their higher influence. Empirical findings further indicate that results are officiated by the intersecting variations in age, gender, ethnicity, occupations, administrative divisions and establishment size.
Integrating modified WebQuest activities for programming learning
Authors: Wang Yi‐Hsuan 
Published: February 2021

AbstractThe study designed WebQuest activities and explored the learning performance of learners to understand the suitability of using WebQuest in a college programming course. The study modified the processes of WebQuest based on social constructivism and scaffolding learning, and included programming tasks such as debugging practice to encourage learners to develop their problem‐solving abilities. The WebQuest learning sheets include the following four parts, introduction, task, resources and evaluation, and the learners had to complete the tasks without the detailed processes. After they had tried to solve the problem for approximately two weeks, the detailed WebQuest processes were provided. A total of 109 learners (third year of college) participated in the study and were separated into two groups. The experimental group underwent WebQuest teaching, while the control group received the traditional IT‐integrated teaching. The study duration was 18 weeks (3 hr/week). The results indicated that the modified WebQuest activity gave learners scaffolding to do try‐and‐revise practice, and the processes of using provided possible information to test and debug the resulting codes encouraged them to associate and analyze learning information before programming and then to generalize the programming steps on their own instead of following the instructor's step‐by‐step instructions. The learners thus have a deep understanding of the programming concept rather than surface learning. The findings revealed that the modified WebQuest activity is a helpful form of scaffolding for promoting learners' positive learning experiences regarding organizing information and problem solving and reasoning skills. Besides, integrating debugging practice in the WebQuest activity could promote learners' intermediate and advance level programming ability. Subsequent research could further explore the effects of adding after‐practice WebQuest activities to assist and trigger learners' self‐reflection for refining their problem‐solving processes after the in‐class WebQuest activities.
Ablation Index‐guided high‐power (50 W) short‐duration for left atrial anterior and roofline ablation: Feasibility, procedural data, and lesion analysis (AI High‐Power Linear Ablation)
Authors: Zanchi Simone , Chen Shaojie , Bordignon Stefano , Bianchini Lorenzo , Tohoku Shota , Bologna Fabrizio , Tondo Claudio , Chun K. R. Julian , Schmidt Boris 
Published: February 2021

AbstractObjectivesTo evaluate the feasibility, procedural data, and lesion characteristics of the anterior line (AL) and roofline (RL) ablation by using ablation index (AI)‐guided high power (50 W) among patients with recurrent atrial fibrillation (AF) or atrial tachycardia (AT) after pulmonary vein isolation (PVI).MethodsData from 35 consecutive patients with macro‐reentrant left atrial tachycardia or substrate at the left atrium anterior wall or roof after previous PVI were collected. Ablation power was set to 50 W, targeting AI 500 for AL and 400 for RL. The first‐pass conduction block (FPB) was evaluated. The AL was arbitrarily divided into three (caudal, middle, and cranial) segments to analyze the location of conduction gaps in non‐FPB patients.ResultsA total of 32 AL and 17 RL were deployed and FPB was achieved in 24 (75%) and 14 (82%) of them, respectively. In the non‐FPB group, the most frequent gap location along the AL was the middle third. The final block of AL was achieved in 97%, and the block of RL was achieved in 100%. The radiofrequency (RF) ablation time was short (2.9 ± 0.8 min for AL and 46.2 ± 15.6 s for RL). For AL, the female gender was significantly more frequent in FPB than in non‐FPB patients (p = .028); patients with non‐FPB were associated with significantly longer RF time as compared to patients with FPB (204 ± 47 s vs. 161 ± 41 s; p = .02). No procedural complications occurred.ConclusionAI‐guided high‐power (50 W) ablation appears to be a feasible, effective, and fast technique for AL and RL ablation.
Comparison of guidelines for the management of hypertension: Similarities and differences between international and Asian countries; perspectives from HOPE‐Asia Network
Authors: Chia Yook‐Chin , Turana Yuda , Sukonthasarn Apichard , Zhang Yuqing , Shin Jinho , Cheng Hao‐Min , Tay Jam Chin , Tsoi Kelvin , Siddique Saulat , Verma Narsingh , Buranakitjaroen Peera , Sogunuru Guru P. , Nailes Jennifer , Van Minh Huynh , Park Sungha , Teo Boon W. , Chen Chen‐Huan , Wang Tzung‐Dau , Soenarta Arieska A. , Hoshide Satoshi , Wang Ji‐Guang , Kario Kazoumi ,   the Hypertension Cardiovascular Outcome Prevention, Evidence (HOPE) Asia Network
Published: February 2021

AbstractGuidelines on the management of hypertension have been developed by various professional bodies and institutions to primarily address the issues of diagnosis, treatment, and control in order to rationalize and improve the management of hypertension. Hypertension guidelines across the world have recently been updated following the new and controversial lower blood pressure threshold of ≥130/80 mmHg for the diagnosis of hypertension adopted by the Americans. While there are differences between the major as well as between the Asian national guidelines, there were also many similarities. This paper discusses and highlights the differences and similarities between the major international guidelines of the American College of Cardiology/American Heart Association, of the European Society of Cardiology/European Society of Hypertension, and of the International Society of Hypertension and also compares them with the Asian guidelines.
Interactions of anthropometric indices, rs9939609 FTO gene polymorphism and breast cancer: A case‐control study
Authors: Doaei Saeid , Bourbour Fatemeh , Rastgoo Samira , Akbari Mohammad Esmail , Gholamalizadeh Maryam , Hajipour Azadeh , Moslem Alireza , Ghorat Fereshteh , Badeli Mostafa , Bagheri Seyedeh Elaheh , Alizadeh Atieh , Mokhtari Zohreh , Pishdad Samaneh , JavadiKooshesh Sepehr , Azizi Tabesh Ghasem , Montazeri Fateme , Joola Parvin , Rezaei Shahla , Dorosti Masoomeh , Mosavi Jarrahi Seyed Alireza 
Published: February 2021

AbstractContradictory results were reported on the effect of fat mass‐ and obesity‐associated (FTO) gene and anthropometric measurements on breast cancer (BC). This study aimed to assess the interactions between rs9939609 polymorphism of FTO gene, anthropometric indices and BC risk in Iranian women. This case‐control study was performed on 540 women including 180 women with BC and 360 healthy women in Tehran, Iran. Physical activity and dietary intakes were assessed by validated questionnaires. Data on sociodemographic and pathologic factors of the participants as well as their blood samples were collected. The rs9939609 FTO gene polymorphism was genotyped using the tetra‐primer amplification refractory mutation system‐polymerase chain reaction (T‐ARMS‐PCR). No significant association was found between BC and risk allele of FTO rs9939609 polymorphism after adjustments for the confounders. However, there was a significant association between rs9939609 polymorphism risk allele and BC risk in females with overweight, even after adjusting for age, family history of BC, abortion, BMI and the number of pregnancies (P < .05). The association was disappeared after further adjustments for lifestyle factors including smoking, alcohol consumption, calorie and macronutrients intake, and physical activity. The FTO gene polymorphism was associated with the risk of BC in overweight individuals. This association was influenced by environmental factors including diet, alcohol consumption and smoking. Future studies are required to confirm the association between the FTO gene and BC in overweight females and to identify the underlying mechanisms.
Impact of language disorders on children’s everyday lives from 4 to 13 years: Commentary on Le, Mensah, Eadie, McKean, Schiberras, Bavin, Reilly and Gold (2020)
Authors: Lyons Rena 
Published: February 2021

This paper by Le et al. (2020) is a valuable addition to the literature because it provides evidence regarding the trajectories of health‐related quality of life (HRQoL) in children with language disorders from the ages of 4–13 years. The authors found that higher language scores were associated with better HRQoL particularly in the school and social domains. Of the children in the low language group, 40% were in the stable‐high HRQoL trajectory, while the others were in the reduced‐slow‐decline (26%) and low‐rapid‐decline (34%) HRQoL groups. Despite the prevalence of language disorder and its impact on many aspects of children’s everyday lives, many professionals and members of the public are still unaware of this condition and its potential consequences. The publication of the Le et al. (2020) paper is timely because it coincides with a call to action to support these children by McGregor (2020). McGregor (2020) argued that we fail children with developmental language disorders both in terms of research and service provision. In her recent discussion paper, she provided evidence that these children face significant risks with regard to academic achievement: they are 6 times more likely to have reading disabilities, 6 times more likely to have spelling difficulties, 4 times more likely to have difficulties with mathematics and 12 times more likely to present with all three difficulties.
Relational Dialectics Theory
Authors: Baxter Leslie A. , Scharp Kristina M. , Thomas Lindsey J. 
Published: February 2021

AbstractThis article first provides an overview and brief history of relational dialectics theory (RDT) before turning to a presentation of RDT's basic tenets and theoretical utility. In addition, it also examines how RDT has been applied in studying family contexts and offers suggestions for future directions of RDT‐based research.
Credit Supply and Demand in Unconventional Times
Authors: ALTAVILLA CARLO , BOUCINHA MIGUEL , HOLTON SARAH , ONGENA STEVEN 
Published: February 2021

AbstractDo borrowers demand less credit from banks with weak balance sheets, following monetary policy shocks? To answer this, we use novel bank‐specific survey data matched with balance sheet information for euro area banks. We find that, following a monetary policy shock, bank strength influences credit demand as well as credit supply. Bank resilience is important for firms when selecting a lender and it is therefore vital to control for bank‐specific demand when identifying credit supply shocks. An application using bank‐specific demand shows that—even after fully controlling for demand, borrower quality, and bank strength—unconventional monetary policies stimulate loan supply.
Stop the rot. Enzyme inactivation at brain harvest prevents artifacts
Authors: Dienel Gerald A. 
Published: February 2021

AbstractPost‐mortem metabolism is widely recognized to cause rapid and prolonged changes in the concentrations of multiple classes of compounds in brain, that is, they are labile. Post‐mortem changes from levels in living brain include components of pathways of metabolism of glucose and energy compounds, amino acids, lipids, signaling molecules, neuropeptides, phosphoproteins, and proteins. Methods that stop enzyme activity at brain harvest were developed almost 50 years ago and have been extensively used in studies of brain functions and diseases. Unfortunately, these methods are not commonly used to harvest brain tissue for mass spectrometry‐based metabolomic studies or for imaging mass spectrometry studies (IMS, also called mass spectrometry imaging, MSI, or matrix‐assisted laser desorption/ionization‐MSI, MALDI‐MSI). Instead these studies commonly kill animals, decapitate, dissect out brain and regions of interest if needed, then ‘snap’ freeze the tissue to stop enzymatic activity after harvest, with post‐mortem intervals typically ranging from ~0.5 to 3 min. To increase awareness of the importance of stopping metabolism at harvest and preventing the unnecessary complications of not doing so, this commentary provides examples of labile metabolites and the magnitudes of their post‐mortem changes in concentrations during brain harvest. Brain harvest methods that stop metabolism at harvest eliminate post‐mortem enzymatic activities and can improve characterization of normal and diseased brain. In addition, metabolomic studies would be improved by reporting absolute units of concentration along with normalized peak areas or fold changes. Then reported values can be evaluated and compared with the extensive neurochemical literature to help prevent reporting of artifactual data.
image
Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology: Annual patient report for 2017 and annual treatment report for 2012
Authors: Nagase Satoru , Ohta Tsuyoshi , Takahashi Fumiaki , Yaegashi Nobuo ,   Board members of the 2020 Committee on Gynecologic Oncology of the Japan Society of Obstetrics and Gynecology
Published: February 2021

AbstractAimTo provide information including the trend of gynecological malignancies in Japan, we hereby present the Annual Patient Report for 2017 and the Annual Treatment Report for 2012, on the outcomes of patients who started treatment in 2012.MethodsThe Japan Society of Obstetrics and Gynecology maintains an annual tumor registry, where information on gynecological malignancies from various participating institutions is gathered. The data of patients whose treatment with gynecologic malignancies was initiated in 2017 were analyzed retrospectively. Survival of the patients who started treatment with cervical, endometrial and ovarian cancer in 2012 was analyzed by using the Kaplan‐Meier, log‐rank and Wilcoxon tests.ResultsTreatment was initiated in 2017 for 7710 patients with cervical cancer; 11 120 with endometrial cancer; 7029 with ovarian, tubal and peritoneal cancer; 2164 with ovarian borderline tumors; and with the others (213 vulvar cancer, 139 vaginal cancer, 366 uterine sarcoma, 41 uterine adenosarcoma and 131 trophoblastic diseases). This clinicopathological information was summarized as the patient annual report. The 5‐year survival rates of the patients with cervical cancer were 92.9, 75.5, 58.2 and 26.7% for stages I, II, III and IV, respectively. The 5‐year survival rates for the patients with endometrial cancer were 93.6, 85.6, 72.6 and 27.3% for stages I, II, III and IV, respectively. The 5‐year survival rates for the patients with ovarian cancer (surface epithelial‐stromal tumors) were 92.5, 83.5, 49.5 and 30.8% for stages I, II, III and IV, respectively.ConclusionThe annual tumor report is an important survey that provides knowledge on gynecological malignancy trends in Japan.
Development and progression of proteinuria in dogs treated with masitinib for neoplasia: 28 cases (2010‐2019)
Authors: Kuijlaars M. , Helm J. , McBrearty A. 
Published: February 2021

ObjectivesTo describe the incidence, severity and progression of proteinuria over the first 6 months of masitinib treatment in tumour‐bearing dogs without pre‐existing proteinuria. To describe the effect of treatment on urine protein:creatinine and renal parameters in patients with pre‐existing proteinuria.Materials and MethodsRecords were reviewed from patients receiving masitinib for neoplasms between June 1, 2010, and May 5, 2019. Patients without pre‐treatment and at least one urine protein:creatinine after ≥7 days treatment were excluded. Signalment, tumours and concurrent diseases, treatments, haematology, biochemistry and urinalysis results before, during and after treatment for up to 202 days were collected. Patient visits were grouped into six timepoints for analysis.ResultsTwenty‐eight dogs were included. Eighteen percent of dogs non‐proteinuric at baseline (four of 22) developed proteinuria during treatment, all within 1 month of treatment initiation. One dog developed hypoalbuminaemia, none developed oedema or ascites, azotaemia or were euthanased/died due to proteinuria. Masitinib was immediately discontinued in both dogs in which urine protein:creatinine greater than 2.0 was detected and in both, proteinuria improved.Six dogs with pre‐treatment proteinuria were treated with masitinib, significant worsening of proteinuria did not occur. Neither azotaemia nor severe hypoalbuminaemia occurred.Clinical SignificanceProteinuria, when it occurs, tends to develop within 1 month of masitinib commencement and may progress rapidly. Weekly proteinuria monitoring should be considered for the first month and a urine protein:creatinine greater than 0.5 should prompt reassessment within 1 week. Masitinib treatment can be considered in patients with pre‐treatment proteinuria and does not inevitably cause worsening of proteinuria.
Light chain myeloma and detection of free light chains in serum and urine of dogs and cats
Authors: Harris Robert Adam , Miller Matthew , Donaghy Dillon , Ashton Laura , Langston Catherine , Shockey Todd , Moore A Russell 
Published: February 2021

AbstractBackgroundDetection of free light chains (fLC) in animals relies on protein electrophoresis or the Bence‐Jones protein test on urine.ObjectiveTo describe the detection of both serum fLC (sfLC) and urine fLC (ufLC) in 8 dogs and 2 cats using a commercially available human immunofixation (IF) kit.AnimalsArchived serum or urine samples from 27 dogs and 2 cats submitted to the Colorado State University Veterinary Diagnostic Laboratory for routine diagnostics.MethodsRetrospective study evaluating the presence of fLC in dogs and cats using agarose gel electrophoresis and routine and fLC IF performed on serum and urine. The performance of the fLC IF reagents was evaluated using samples characterized by routine IF, tandem mass spectrometry, and a combination of fLC IF and western blotting. Free light chains were documented by paired electrophoresis and fLC IF.ResultsThe fLC only myeloma case developed end‐stage renal failure 5 months post initial diagnosis. All electrophoresis‐defined urinary Bence‐Jones proteins were labeled by the anti‐free λ light chain (anti‐fλ) reagent; none were labeled by the anti‐free κ light chain (anti‐fκ); 2 of these were identified as fκ by mass spectrometry. An electrophoretically identical protein restriction that was labeled by the anti‐fλ reagent was present in the paired serum from 5/8 of cases, documenting sfLC.Conclusions and Clinical ImportanceCommercially available human IF reagents identified sfLC and ufLC in both dogs and cats. Free light chains may be nephrotoxic in dogs.