bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report on Subarachnoid Hemorrhage
Authors: Tighare Reshma , Sharma Ranjana 
Published: November 2021

Introduction: Subarachnoid haemorrhage (SAH) is caused by intracranial bleeding into the cerebrospinal fluid-filled space between the arachnoid and pia mater membranes on the surface of the brain.
Patient History: The 65-year-old female patient was hospitalised to AVBR hospital in neurosurgery ward on December 25, 2020 with the chief complaints of headache, vomiting and episodes of seizures since three days. The patients had episodes of seizures on 21/12/2020 and 24/12/2020. The day later she was admitted to the Intensive Care Unit.she underwent all routine investigations like blood tests, and CT scan. After a thorough examination, the final diagnosis was subarachnoid haemorrhage.
Past History: Patient did not have any history of communicable disease, asthma, tuberculosis, or any hereditary disease. Patient was COVID – negative and did not have any significant surgical history.
Pharmacology: Patient was treated with proton pump inhibitor, antiemetic, antiepileptic, calcium channel blocker, stool softener analgesic and antipyretic.
Management: Inj. Levipril 500 mg, Inj.pan40-40mg, cap.nimodipine 60mg every four hourly, Inj.emset 4 mg, Inj. Neomol 100 ml, Syp. glycerol 30 ml, Syp. Zincovit 2tsp and Tablet Dolo 650mg.
Nursing Management: Patient’s vital sign (including blood pressure) and neurological status were monitored with bed rest, pain management and assessment of risk of bleeding.
Conclusion: Patient was hospitalised with a threeday history of headache, vomiting, and episodes of seizures actively managed; condition satisfactory.
Physiotherapeutic Approach for Osteochondroma of 4th And 5th Ribs - A Case Report
Authors: Bhoge Shruti , Phansopkar Pratik , Chitale Neha 
Published: November 2021

The most frequent benign bone tumor is osteochondroma, which account for 45 percent of all benign bone tumours. Although not a real neoplasm, osteochondroma (exostosis) is the most common lesion and is often classed as a tumour. The majority of them develop in the metaphyseal region of long bones like the femur and tibia. A 21-year-old female presented to the orthopedic OPD with complaints of pain and swelling over dorsal spine since 2 years with left upper limb radiculopathy since 1 month. Pain was insidious in onset which started 1 month back and it aggravated ever since. On inspection swelling present over paraspinal region of approximately 5cm in length and 4cm in width. On palpation swelling was not adherent to skin, immobile and firm in consistency. Osteochondroma represent the most common bone tumor accounting for 20 to 50% of all benign osseous tumors. In osteochondroma maintaining mobility is important for activities of daily living and to maintain the quality of life. Physiotherapy plays a significant role in maintaining the mobility and improving the quality of life.
Antioxidant and Anti-Aging Activity of Green Mustard Ethanol Extract Gel
Authors: Handayani Silvia , Fachrial Edy , Amansyah Adek , Lister I. Nyoman Encrich 
Published: November 2021

The skin is the organ of the body that is frequently exposed to direct UV rays from the sun, which causes the formation of ROS (reactive oxygen species), leading to cell death and tissue damage. This health problem can be overcome by using antioxidants to stabilize the free radicals. Mustard as an organic substance which contains polysaccharide compounds, vitamin C, carotene, quercetin, routine compounds, kaempferol and β-cytostreol, all of these are beneficial to skin health and beauty. Therefore, this study aims to determine the antioxidant activity of the total flavonoids and phenol content of mustard ethanol extract using the DPPH method. Furthermore, the extract at concentrations of 2, 4, and 6% was also tested for its anti-aging activity using the following parameters: moisture and oil content, texture, collagen, wrinkles, pigment, sensitivity, and pores. The results showed that the antioxidant activity of the green mustard had an IC50 value of 170.7839 µg/ml, a total phenol content of 14.471 mg GAE/g extract and flavonoid content of 12.753 mg QE/g extract. The effectiveness of the aging activity of the extract was tested using formulation 6%, which is better than 2%, and 4%. Thus, the percentage of water content recovery, oil content, texture, collagen, wrinkles, stains, sensitivity and pores respectively was 36.41, 39.33, 64.07, 17.65, 65.28, 50.14, 49.10 and 35.09%. Consequently, it was concluded that the extract has the potential of being developed into a herbal beauty product.
Effect of Amphiphilic Graft Co-Polymer Carrier on Solubility and Dissolution Enhancement of Ambrisentan
Authors: Radke Rahul , Jain Neetesh K. 
Published: November 2021

Aim: Ambrisentan is a endothelin type A selective receptor antagonist used in the management of pulmonary arterial hypertension. Ambrisentan is BCS Class II drug haves very poor solubility in water and shows incomplete absorption after oral administration. The present work was aimed to study the effect of amphiphilic graft co-polymer carrier on enhancement of solubility and dissolution rate of poorly water soluble drug ambrisentan. To improve the aqueous solubility of ambrisentan solid dispersion was formulated by using novel carrier amphiphilic graft co-polymer (Soluplus® ).
Materials and Methods: Solid dispersion was prepared by kneading technique by utilizing various ratios of carrier. Obtained solid dispersions ware evaluated for solubility, percentage yield, drug content and in vitro dissolution study. Powder characterization was performed by infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), and X-ray diffraction (XRD).
Results: FTIR spectroscopy shows no interaction between drug and polymer. DSC study showed that endothermic peak of drug was completely disappeared in Solid dispersion suggesting complete miscibility of drug in Soluplus®. XRD study suggest the conversion of crystalline ambrisentan in to amorphous form. All solid dispersions prepared with Soluplus® as a carrier showed increase in solubility. Solubility of ambrisentan was found to be increased 7.17 fold in optimized SD formulation ASD5. In vitro dissolution study showed the faster drug release from SD formulation compare to its pure form. All solid dispersion formulation’s release more than 50% of drug in first 10 min.
Conclusion: This study conclude that the preparation of amphiphilic graft co-polymer based solid dispersion prepared by kneading technique is found to be useful in enhancement the solubility and dissolution rate of ambrisentan.
Effectiveness of Video-assisted Intervention on Perception and Anxiety among Patients Undergoing Robotic Surgery in a Selected Hospital, Mangaluru
Authors: Vineesha P. V. , Imran Syed 
Published: November 2021

Background: There are times when a procedure may have benefits, but a patient is unwilling to undergo surgery for their own reasons. Making this choice is their right. Many patients view surgery as a last option, rather than their first choice in treatments. The need for a surgery can be a confusing and frightening prospect and people may have many questions. Robotic assisted surgery has a great future in India, but majority people are not aware about robotic surgery.
Purpose: To focus on the level of anxiety and perception among robotic surgery patients and it has also identified the need for a video assisted intervention for patients undergoing robotic surgery.
Methods: A video assisted intervention on perception(perception rating scale-20 items) and anxiety (State Anxiety Inventory-20 items) among study participants(n=30) undergoing robotic surgery were selected by purposive non probability sampling by means of self administered questionnaire.
Results The perception mean difference pretest-post-test 1(18.80±7.45), pretest-post test 2 (21.83±8.00) and post-test 1- post-test 2 (3.03±7.18). The level of perception has increased from pre-test to post-test 1 and from post-test 1 to post-test 2 and it is statistically significant (p< 0.05). The anxiety mean difference pre-test-post-test 1 (11.27±12.98), pre-test-post test 2 (21.40±13.38) and post-test 1-post-test 2 (10.13±10.89). The level of anxiety has decreased from pre-test to post-test 1, from post-test 1 to post-test 2, and it is statistically significant (p< 0.05).
Conclusion: The findings of the study showed that the video assisted intervention was effective on levels of anxiety and perception among patients undergoing robotic surgery.
Sitagliptin and Acute Pancreatitis: A Systematic Review and Meta-analysis
Authors: Mirghani Hyder Osman , S. Shaman S. Shaman Salem Ahmed , Hussain Aljwah Ibrahim Mahmoud 
Published: November 2021

Background and Objectives: Sitagliptin is a dipepidyl peptidase inhibitor (DPP-4i) with gentle antidiabetic effects with a lower risk of hypoglycemia. The association with acute pancreatitis is controversial. The current meta-analysis aimed to assess the relationship of sitagliptin and acute pancreatitis.
Methods: The literature in PubMed and Google Scholar was searched for relevant articles published in the last ten years up to September 2021. The keywords sitagliptins, DPP-4i, acute pancreatitis were used with the protean AND or OR. Among the 204 articles retrieved, 24 full-texts were assessed for eligibility and only five studies (Three from the USA, one from Asia, and one from Canada) met the inclusion criteria for the systematic review. The author name, year of publication, country, type of study, number of patients, and the duration of the study were reported.
Results: There were five studies. The total number of patients were 729808 with 6459 events. The studies showed no increased rate of acute pancreatitis following sitagliptin use, odd ratio, 0.79, 95% CI, 0.29-2.15, a significant heterogeneity was observer, I2 for heterogeneity=98%, P-value, <001, the P-value for overall effect was 0.65 and the chi-square, 160.15.
Interpretation and Conclusion: Sitagliptin use is not associated with acute pancreatitis.
Effect of Prone Positioning on Oxygen Saturation in COVID-19 Patients in Sri Aurobindo Hospital, Indore
Authors: Misra Anand , Pal Akshay , Pawar Rajni 
Published: November 2021

Background: Physiotherapeutic intervention body positioning have been observed to increase oxygen saturation. In COVID-19 patients, we intended to investigate how the prone position worked in conjunction with conventional respiratory physiotherapy. The objective was to determine the effect of prone position along with conventional respiratory physiotherapy on SpO2 of COVID-19 patients in Aurobindo hospital, Indore district.
Methods: The Ministry of Health, Government of India, authorized the rules for collecting data from infected patients. In this study, 400 patients between the ages of 20 and 80 years old were recruited from Sri Aurobindo Hospital in the Indore district, all of them had a confirmed diagnosis of COVID-19 and required oxygen treatment. SpO2 data was collected as a baseline. Patients were helped into the prone position after baseline data collection and conventional respiratory physiotherapy. Clinical data was obtained again after using the prone posture in conjunction with conventional respiratory physiotherapy. To demonstrate the various prone variations, a patient information sheet was supplied. At 0 and 60 minutes after the exercise, oxygen saturation was measured.
Results: Between April 2020 to June 2020, we assessed SpO2 of 400 Patients pre and post prone position along with conventional respiratory physiotherapy. Prone positioning was feasible. Oxygenation was significantly improved from supine to prone position. The data were processed for mean and standard deviation. It was analyzed that there was difference in pre to post value of mean, from 95.685 to 98.123 with standard deviation from 1.645to 1.445. The result shows significant improvement in SpO2 after applying prone positioning in patients infected with COVID-19. The findings suggest that prone positioning is both possible and beneficial in increasing blood oxygenation in awake COVID-19 patients. Further study is needed to find the technique's potential value in terms of enhancing overall respiratory and global outcomes.
Conclusion: The difference between the saturation of the two position was significant.
A Comparative Study to Evaluate the Effect of Blood Flow Restriction Therapy and Retro Walking on Pain, Strength of Muscles and WOMAC Score in Patients of Osteoarthritis of Knee
Authors: Gurjalwar Indrani , Patil Deepali 
Published: November 2021

Aim: To assess the impact of blood flow restriction and retro walking in knee osteoarthritis subjects.
Study Design: It was a comparative study. All the participants who meet inclusion criteria gave a written consent and were allocated to Group A or Group B randomly by chit method and the pre and post test scores were derived. The scores obtained in the two groups were compared and the results were derived.
Place and Duration of the Study: This study was conducted in musculoskeletal sciences division, RNPC Sawangi, Wardha, for 12 months
Methodology: A total of 150 samples were chosen. Using the chit method, they were divided into two groups at random, Group A and Group B. Blood Flow Restriction Training was given to Group A, while retro walking training was given to Group B. The training lasted 15 days. After 15 days, the pain, strength, and WOMAC score were tested again.
Result: Out of 150 patients 75 were placed in each group, where p=.0001. Significant increase was seen in mean of group I and II in pre ad post-test NPRS score, Quadricep and hamstrings muscle strength and WOMAC score. Analysis showed significant improvement in both the groups.
Conclusion: Both the interventions included in this study, have been shown to help individuals with osteoarthritis reduce pain, enhance strength, and improve their WOMAC score. Both the interventions are easy to practice and can be easily performed by the older population. When these two interventions were compared blood flow restriction therapy was proved to be better than retro walking.
Accuracy of Impression Material During COVID-19 after Sterilization- In vitro Study
Authors: Alhaddad Abdulrahman Jafar 
Published: November 2021

Aims: The goal of this research is to assess the effect of steam autoclave sterilization due to the impact of Covid-19 on the accuracy of the elastomer impression materials.
Study Design: In vitro study.
Place and Duration of Study: Department of oral and Maxillofacial Prosthodontics, King Abdul-Aziz University, Jeddah; Saudi Arabia, between June 2021 and November 2021.
Methodology: The following materials were used in this study: fully dentate master cast, metal trays, elastomer impression material (addition silicon), type IV stone. Forte impressions made using the metal tray and elastomer impression materials. The impressions were separated equally into two groups: Control group (C.G), untreated impressions. Sterilized group (S.G): Impressions were sterilized by using the steam autoclave. To make stone castings for each group, they were poured with type IV stone. The traveling microscope was used to evaluate the impression material's dimensional accuracy and detail reproduction with and without autoclave sterilization.
Results: The cross-arch distance (X) of the master model was measured (41.29 mm), While the cross arch distance (X) in the control group (C.G) of the untreated impressions had a mean and standard deviation of 41.492 ± 0.150 mm. In the tested group (S.G) : the sterilized impression, we found the cross-arch distance (X) had a mean and standard deviation of 41.628 ± 0.223 mm. The master model's Anteroposterior distance (A-P) was measured (21.12 mm). For the control group (C.G) : we found the mean and standard deviation value reading of the A-P distance were 20.899 ± 0.79 mm. For (S.G) group: we found the mean and standard deviation reading of the A-P distance were 19.992± 0.482 mm.
Conclusion: Steam autoclave sterilization of the elastomer impression material should be considered carefully, especially when fabricating fixed partial dentures. If the impression material is to be used in making diagnostic castings, conventional steam autoclave sterilization of the elastomers impression material may be sufficient for patients.
Isolation, Identification and Antibiotic Susceptibility of Escherichia coli Isolated from Raw Meat from Modake and Ile-Ife, Osun State, Nigeria
Authors: Damilola Wilkie Eunice , Olufunke Oluduro Anthonia , Vivian Ezeani Chidinma , Teniola Sotala Toyosi 
Published: November 2021

The study reported isolation, identification and antibiotic susceptibility of Escherichia coli isolated from raw meat from Modakeke and Ile-ife, Osun State, Nigeria, with the view to determining the antibiogram profiling of the bacterial isolates.
In this study, five samples of fresh meat were collected from different abattoirs in Ile-Ife and Modakeke, Osun State. Isolates of Escherichia coli were isolated, identified morphologically based on their growth on nutrient agar and subjected to antibiotic susceptibility test on Mueller Hinton agar. The mean microbial load from the meat samples ranged from 8.85 x 102cfu/ml to 5.77 x 104cfu/ml. A total of 69 E. coli isolates were recovered from the meat sampled. All the isolates appeared cream, translucent, entire, convex, circular, smooth and glistering. The isolates were identified as Gram negative rods, non-motile, lactose fermenters, positive for indole test and negative for citrate utilization test. All the E. coli isolates were resistant to augmentin, ceftriazone, nitrofurantoin and gentamycin. 98.55% of E. coli isolated was resistant to amoxillin and the least resistant was recorded in ofloxacin (8.70%). However, 91.30% of the E. coli isolates was sensitive to ofloxacin, 81.16% to ciprofloxacin and 36.23% to pefloxacin while none was sensitive to augmentin, ceftriazone, nitrofurantoin and gentamycin. A total of 19 different multiple antibiotic resistance patterns were observed among the isolates. Thirty isolates (43.48%) showed multiple antibiotic resistance to 5 and 10 different antibiotic types each.
The study concluded that occurrence of E. coli infection is high in the study area with high level of multiple antibiotic resistance.
Effects of Remittances on Income Inequality in Bangladesh: A Macroeconomic Analysis
Authors: -Nessa Hazera-Tun 
Published: November 2021

This study attempts to examine the effects of remittances on income inequality in Bangladesh over the period of 1990 to 2016. The study period has been chosen based on data availability at macro level. To serve the purpose, Autoregressive Distributed Lag (ARDL) cointegration technique is applied since unit root test confirms a combination of variables some which are stationary at level and others become stationary after first difference. The error correction model estimated by reparametrizing the ARDL model after having confirmation about the existence of long run relationship through bound test. An inverted U-shaped relationship between the remittances and income inequality has been found by the study. Remittances increase income inequality in short run and decrease income inequality in the long run. In the long run an increase in remittances by 1 per cent reduces the income inequality by 11 per cent on an average. The adjustment coefficient has the expected negative sign at 1 per cent level of significance which ensure a monotonically convergent adjustment towards the equilibrium with the speed of 21.65 per cent. Among other control variables, private credit increases income inequality in the long run and decrease it in the short run. Exchange rate and inflation either have very negligible effects or no significant effects both in short run and in long run. Based on the findings, it could be suggested that the country should take proper steps to encourage investment of remittances in productive activities to accumulate capital which could ensure the path of accruing the beneficial impacts of remittances on income inequality in the long run.
3D Programmable Metamaterials Based on Reconfigurable Mechanism Modules
Authors: Liu Weiqi , Jiang Hanqing , Chen Yan 
Published: November 2021

AbstractMechanical metamaterials are of tremendous research interest due to their unconventional properties that arise from unit microstructure. Shape‐reconfiguration is an effective method to realize programmability on various properties for different tasks of a structure or system, while existing researches focus on multiple degree‐of‐freedom (DOF) systems or limited configurations that morph along a single kinematic path. Here, starting from a one‐DOF Wohlhart polyhedron module, its interesting topological transformation is explored along multiple motion paths through kinematic bifurcations, accompanied by tunable mechanical properties, including Poisson's ratio, chirality, and stiffness. Furthermore, these modules are tessellated into 3D metamaterials to harness their reconfigurability to independently program the Poisson's ratios in orthogonal planes within a wide range of negative Poisson's ratio, positive Poisson's ratio, and even zero Poisson's ratio. This work opens up avenues for the design of programmable metamaterials based on the perspective of kinematic bifurcation generating from single DOF systems, which can readily be applied in shape‐morphing systems in various fields, such as flexible metamaterials, morphing architectures, and deployable structures.
Nanomaterial Functionalization Modulates Hard Protein Corona Formation: Atomistic Simulations Applied to Graphitic Materials
Authors: al‐Badri Mohamed Ali , Smith Paul , al‐Jamal Khuloud T. , Lorenz Christian D. 
Published: November 2021

AbstractThe protein corona is an obstacle to exploiting exotic properties of nanomaterials in clinical and biotechnological settings. The atomic‐scale dynamic formation of the protein corona at the bio‐nano interface is impenetrable using conventional experimental techniques. Here, molecular dynamics simulations are used to study the effect of graphene‐oxide (GO) functionalization on apolipoprotein‐cIII (apo‐c3) adsorption. An analysis pipeline is developed, encompassing binding energy calculations to protein structure analyses employing uniform manifold approximation and projection (UMAP) dimensionality reduction and clustering. It is found that apo‐c3 is denatured by GO adsorption, driven by the large energetic contributions of electrostatic interactions; enthalpic contributions of such binding events outweigh the intraprotein bond enthalpy required to maintain the protein tertiary structure. Through denaturing and exposing buried hydrophobic residues, the protein backbone is stabilized by forming β‐bridges, which serve as binding motifs for protein–protein interactions that drive further protein aggregation on the nanomaterial surface. In contrast, adsorption on double‐clickable azide‐ and alkyne‐double functionalized GO (C2GO), apo‐c3 largely retains its tertiary structure. Binding with the nanomaterial surface is dominated by weaker van der Waals interactions that are dispersed over the protein surface, where charged protein residues are sterically hindered by azide functional groups. The apo‐c3 C‐terminus remains unchanged upon C2GO adsorption, conserving its lipid‐binding function.