bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic mutations and molecular mechanisms of Fuchs endothelial corneal dystrophy
Authors: Liu Xuerui , Zheng Tao , Zhao Chuchu , Zhang Yi , Liu Hanruo , Wang Liyuan , Liu Ping 
Published: June 2021

Abstract
Background
Fuchs endothelial corneal dystrophy is a hereditary disease and the most frequent cause of corneal transplantation in the worldwide. Its main clinical signs are an accelerated decrease in the number of endothelial cells, thickening of Descemet’s membrane and formation of guttae in the extracellular matrix. The cornea’s ability to maintain stromal dehydration is impaired, causing painful epithelial bullae and loss of vision at the point when the amount of corneal endothelial cells cannot be compensated. At present, apart from corneal transplantation, there is no other effective treatment that prevents blindness.

Main text
In this review, we first summarized the mutations of COL8A2, TCF4, TCF8, SLC4A11 and AGBL1 genes in Fuchs endothelial corneal dystrophy. The molecular mechanisms associated with Fuchs endothelial corneal dystrophy, such as endoplasmic reticulum stress and unfolded protein response pathway, oxidative stress, mitochondrial dysregulation pathway, apoptosis pathway, mitophagy, epithelial-mesenchymal transition pathway, RNA toxicity and repeat-associated non-ATG translation, and other pathogenesis, were then explored. Finally, we discussed several potential treatments related to the pathogenesis of Fuchs endothelial corneal dystrophy, which may be the focus of future research.

Conclusions
The pathogenesis of Fuchs endothelial corneal dystrophy is very complicated. Currently, corneal transplantation is an important method in the treatment of Fuchs endothelial corneal dystrophy. It is necessary to continuously explore the pathogenesis of Fuchs endothelial corneal dystrophy and establish the scientific foundations for the development of next-generation corneal therapeutics.
A rare case of accessory liver lobe torsion in a pediatric patient who showed recurrent epigastralgia and who was treated by elective laparoscopic resection
Authors: Nagano Ayaka , Onishi Shun , Kedoin Chihiro , Matsui Mayu , Murakami Masakazu , Sugita Koshiro , Yano Keisuke , Harumatsu Toshio , Yamada Koji , Yamada Waka , Matsukubo Makoto , Muto Mitsuru , Kaji Tatsuru , Ieiri Satoshi 
Published: June 2021

Abstract
Background
Accessory liver lobe (ALL) is a rare liver malformation. An ALL develops due to malformation of the endodermal caudal foregut and segmentation of the hepatic bud in the third week of gestation. Most ALLs are asymptomatic and are detected incidentally during abdominal surgery. The incidence of ALL is < 1% in patients who undergo abdominal surgery. However, some ALLs twist and cause acute abdomen. We experienced a pediatric case of ALL torsion in a patient who underwent elective laparoscopic surgery.

Case presentation
The 5-year-old girl had a 3-month history of epigastralgia and vomiting, which occurred every 2 weeks. Abdominal ultrasonography with color Doppler imaging revealed an 11.8 × 13.6 mm nonvascular lesion with mixed echogenicity near the round ligament of the liver. Enhanced computed tomography confirmed a 14 × 16 × 20 mm low-attenuation mass surrounded by a hyperdense line and disproportionate fat stranding on the right side of the round ligament of the liver. There was no ascites or hemorrhage. These findings suggested an abscess of the round ligament of the liver. Her symptoms improved with the administration of oral antibiotics; thus, we planned to perform elective exploratory laparoscopy and subsequent resection. Two trocars (5 mm) were inserted through a multichannel port device at the umbilicus and one trocar (3 mm) was inserted at the right lateral abdomen. Upon observation of the abdominal cavity, the omentum was observed adhering to the round ligament of the liver. Macroscopic observation revealed no apparent mass lesions. We performed adhesiolysis of the omentum from the round ligament of the liver using a vessel sealing system. We performed resection at the site at which adhesion had formed between the round ligament of the liver with the surrounding tissue using a vessel sealing system and the resected specimen was extracted through the umbilical wound. The postoperative course was uneventful. A pathological examination revealed necrotic liver tissue. The resected tissue was founded to be an ALL with ischemic change.

Conclusions
The recurrent abdominal pain was induced by torsion of the ALL. Pediatric surgeons should consider ALL torsion as a differential diagnosis for epigastralgia of unknown etiology.
Rare case of recurrent stroke in a patient with eosinophilic granulomatosis with polyangiitis: a case report
Authors: Arsenijević Mirjana , Ivančević Nikola , Jovanović Dejana , Radović Milan , Berisavac Ivana 
Published: June 2021

Abstract
Background
Central nervous system involvement is rarely described in eosinophilic granulomatosis with polyangiitis (EGPA) and occurs in 5–9% of patients. Among central nervous system manifestations, cerebral infarctions are the most common. To the best of our knowledge, a recurrent stroke in patients with EGPA without cardiac risk factors during maintenance therapy so far has not been described.

Case presentation
A previously healthy 57-year-old female during the course of 1 year developed asthma, sinusitis, polyneuropathy, muscle weakness, and rash followed by fatigue, myalgia, arthralgia, and fever. After an initial diagnostic evaluation, elevated values of eosinophils, liver enzymes, creatine kinase, lactate dehydrogenase, and inflammatory markers (sedimentation rate and C-reactive protein) were found, and renal impairment was detected. On the third day of hospitalization, she developed left-sided hemiparesis due to an ischemic stroke in the right basal ganglia. She has been diagnosed with EGPA, and oral corticosteroid, immunosuppressive, and antiplatelet therapy were applied. Despite potent treatment and initial recovery, a few weeks later, she developed recurrent ischemic stroke in the left hemisphere and pulmonary embolism as rare and potentially severe complications of EGPA. Assuming that complete disease remission had not been established previously, oral prednisone was initially substituted with intravenous methylprednisolone pulses. During follow-up, immunosuppressive therapy was slowly discontinued, oral corticosteroid therapy was reduced to a maintenance dose, and thromboembolic events were well controlled by oral anticoagulant therapy.

Conclusion
Anticoagulant therapy, in addition to immunosuppressive maintenance therapy, should be considered in any EGPA patient who has had an ischemic stroke even without cardiac risk factors.
Awake surgery for lesions near eloquent brain under scalp block and clinical monitoring: experience of single center with limited resources
Authors: Abdelhameed Esam , Abdelghany Mohamed Shebl , Abdelkhalek Hazem , Elatrozy Hytham Ibrahim Shokry 
Published: June 2021

Abstract
Background
Surgery of the brain tumors near eloquent areas carries the risk of either disabling neurological deficit or inadequate resection with bad prognosis in both situations. Awake surgery is the gold standard procedure for such lesions. However, it requires certain anesthetic drugs, advanced techniques, and trained teams that are not available in every neurosurgical institute. This work aims to evaluate safety, feasibility, and outcome of operating on patients with space occupying lesions near eloquent areas under scalp block being continuously examined by a neurologist through retrospective study of 20 cases with supratentorial lesions related to language or sensorimotor cortex.

Results
There were 12 males and 8 females with mean age 36.8 years. Forty percent of patients were presented by motor weakness. Tumors were related to motor cortex in 11 patients and to language areas in 9 patients. Mean operative time was 210 min. Gross or near total resection was achieved in 15cases, four cases had subtotal resection and biopsy only was done in 1 case. Two patients suffered from intraoperative seizures and conversion to general anesthesia was required in one patient.

Conclusion
Operating on tumors near eloquent brain areas under scalp block and continuous neurological examination during tumor resection proved to be effective in early detection and prevention of permanent major deficits especially in the developing countries with limited resources.
Aberrant expression of multiple T cell markers on diffuse large B cell lymphoma: a case report
Authors: Mehta Anurag , Chadha Prerna , Agarwal Poojan , Pasricha Sunil 
Published: June 2021

Abstract
Background
Aberrant T cell antigen expression has been well documented in diffuse large B cell lymphomas. However, co-expression of multiple T cell antigens including CD3, which has been considered a specific marker for T cells is extremely rare. Awareness about such aberrant expression is important so as not to misdiagnose or wrongly classify a lymphoma. The aim of this article is to report such a case.

Case presentation
A 68-year-old postmenopausal lady, diabetic and hypertensive, presented with an axillary lump of one week’s duration. There was no other relevant medical history. Ultrasonography revealed multiple hypoechoic cystic lesions varying in size from 3.9 to 4.2 cm3. Aspiration was suggestive of an infective pathology. Excision biopsy of the mass was diagnosed as diffuse large B cell lymphoma with aberrant T cell antigen expression. She received 4 cycles of chemotherapy after which she was lost to follow-up.

Conclusion
The case presented as a diagnostic dilemma for the pathologist. The predicament lies in classifying it as a B cell lymphoma with an aberrant expression of T cell markers versus a T cell lymphoma with an aberrant B cell marker expression which has a significant implication on the treatment offered. This can be solved by looking at the expression of the B cell specific transcription factors. The key to diagnosis lies in the knowledge of their existence and the application of a panel of markers.
Childhood Adiposity Associated With Expanded Effector Memory CD8+ and Vδ2+Vγ9+ T Cells
Authors: Looman Kirsten I M , Santos Susana , Moll Henriette A , Leijten Charlotte W E , Grosserichter-Wagener Christina , Voortman Trudy , Jaddoe Vincent V W , van Zelm Menno C , Kiefte-de Jong Jessica C 
Published: June 2021

AbstractContextAdult obesity is associated with chronic low-grade inflammation and may give rise to future chronic disease. However, it is unclear whether adiposity-related inflammation is already apparent in childhood.ObjectiveTo study associations between child adiposity measures with circulating monocytes and naive and memory subsets in CD4, CD8, and γδ T cell lineages.MethodsTen-year-old children (n = 890) from the Generation R Cohort underwent dual-energy x-ray absorptiometry and magnetic resonance imaging for body composition (body mass index [BMI], fat mass index [FMI], android-to-gynoid fat mass ratio, visceral fat index, liver fat fraction). Blood samples were taken for detailed immunophenotyping of leukocytes by 11-color flow cytometry.ResultsSeveral statistically significant associations were observed. A 1-SD increase in total FMI was associated with +8.4% (95% CI 2.0, 15.2) Vδ2+Vγ9+ and +7.4% (95% CI 2.4, 12.5) CD8+TEMRO cell numbers. A 1-SD increase in visceral fat index was associated with +10.7% (95% CI 3.3, 18.7) Vδ2+Vγ9+ and +8.3% (95% CI 2.6, 14.4) CD8+TEMRO cell numbers. Higher android-to-gynoid fat mass ratio was only associated with higher Vδ2+Vγ9+ T cells. Liver fat was associated with higher CD8+TEMRO cells but not with Vδ2+Vγ9+ T cells. Only liver fat was associated with lower Th17 cell numbers: a 1-SD increase was associated with −8.9% (95% CI −13.7, −3.7) Th17 cells. No associations for total CD8+, CD4+ T cells, or monocytes were observed. BMI was not associated with immune cells.ConclusionHigher Vδ2+Vγ9+ and CD8+TEMRO cell numbers in children with higher visceral fat index could reflect presence of adiposity-related inflammation in children with adiposity of a general population.
Newly Discovered Śaiva-Ascetic Icons from West Bengal
Authors: Ghosh Ranjusri 
Published: June 2021

Abstract
Koṭivarṣa, a sacred place and an administrative unit that is mentioned in early medieval Indian religious and epigraphic sources from 700 to 1200 ce, is the area of focus of this essay. As an administrative unit, it was almost coterminous with the old Dinajpur district of Bengal, which is now divided into the present Indian state of West Bengal and Bangladesh. At one point in time, its headquarters came to be known as Devīkoṭa, underscoring its rise as a prime place for Devī, the Mother goddess. Sculptural arrays of the Mother goddess from this place point to the domineering presence of her fearsome principles; they parallel textual descriptions about the sacred importance of a wrathful form of the Mother, normally referred to as Cāmuṇḍā. The religious texts, however, do not speak of the ascetics who might have performed the rituals to propitiate the Mother. We do not yet know if any new dimension was added to the corpus of rituals, and the Śiva-Śakti power equation after the Saiddhāntika Śaiva preceptors affiliated with Golagī great monastery of Durvāsas lineage entered Devīkoṭa at the end of the tenth century. This essay searches for answers in the visual elements on the lower registers of stone steles, such as the devotees/donors, other individuals in the service of the Mother Goddess, potfuls of offerings, and the environment of cremation grounds in which worship took place. The main deity and associated figures occupying the larger space in the middle of the steles have tantric content. Icons of Śaiva ascetics from West Bengal, including the three newly discovered examples, are important subjects for this essay, which concludes with the transformation of Devīkoṭa to Bangarh, where Śiva emerged as the chief god par excellence. The Devī had lost her koṭa, her bastion, forever.
Pressure-induced changes on the morphology and gene expression in mammalian cells
Authors: Okamoto Kazuko , Watanabe Tomonobu M. , Horie Masanobu , Nishiyama Masayoshi , Harada Yoshie , Fujita Hideaki 
Published: June 2021

ABSTRACT
We evaluated the effect of high hydrostatic pressure on mouse embryonic fibroblasts (MEFs) and mouse embryonic stem (ES) cells. Hydrostatic pressures of 15, 30, 60, and 90 MPa were applied for 10 min, and changes in gene expression were evaluated. Among genes related to mechanical stimuli, death-associated protein 3 was upregulated in MEF subjected to 90 MPa pressure; however, other genes known to be upregulated by mechanical stimuli did not change significantly. Genes related to cell differentiation did not show a large change in expression. On the other hand, genes related to pluripotency, such as Oct4 and Sox2, showed a twofold increase in expression upon application of 60 MPa hydrostatic pressure for 10 min. Although these changes did not persist after overnight culture, cells that were pressurized to 15 MPa showed an increase in pluripotency genes after overnight culture. When mouse ES cells were pressurized, they also showed an increase in the expression of pluripotency genes. These results show that hydrostatic pressure activates pluripotency genes in mammalian cells.
This article has an associated First Person interview with the first author of the paper.
Modulating the polarization of broadband terahertz pulses from a spintronic emitter at rates up to 10 kHz
Authors: Gueckstock Oliver , Nádvorník Lukáš , Seifert Tom S. , Borchert Martin , Jakob Gerhard , Schmidt Georg , Woltersdorf Georg , Kläui Mathias , Wolf Martin , Kampfrath Tobias 
Published: June 2021

Reliable modulation of terahertz electromagnetic waveforms is important for many applications. Here, we rapidly modulate the direction of the electric field of linearly polarized terahertz electromagnetic pulses with 1–30 THz bandwidth by applying time-dependent magnetic fields to a spintronic terahertz emitter. Polarity modulation of the terahertz field with more than 99% contrast at a rate of 10 kHz is achieved using a harmonic magnetic field. By adding a static magnetic field, we modulate the direction of the terahertz field between angles of, for instance, −53° and 53° at kilohertz rates. We believe our approach makes spintronic terahertz emitters a promising source for low-noise modulation spectroscopy and polarization-sensitive techniques such as ellipsometry at 1–30 THz.
Negative refraction of ultra-squeezed in-plane hyperbolic designer polaritons
Authors: Chen Qiaolu , Yang Yihao , Zhang Li , Chen Jialin , Li Min , Lin Xiao , Li Rujiang , Wang Zuojia , Zhang Baile , Chen Hongsheng 
Published: June 2021

The in-plane negative refraction of high-momentum (i.e., high-

k

) photonic modes could enable many applications such as imaging, focusing, and waveguiding in a planar platform at deep-subwavelength scales. However, its practical implementation in experiments remains elusive so far. Here we propose a class of hyperbolic metasurfaces, which is characterized by an anisotropic magnetic sheet conductivity and can support the in-plane ultra-high-

k

magnetic designer polaritons. Based on such metasurfaces, we report the experimental observation of the all-angle negative refraction of designer polaritons at extremely deep-subwavelength scales. Moreover, we directly visualize the designer polaritons with hyperbolic dispersions. Importantly, for these hyperbolic polaritons, we find that their squeezing factor is ultra-large. To be specific, it can be up to 129 in the experiments, an ultra-high value exceeding those in naturally hyperbolic materials. This work may pave a way toward exploring the extremely high confinement and unusual propagation of magnetic designer polaritons over monolayer or twisted bilayer hyperbolic metasurfaces.
SARS-CoV-2 screening among people living in homeless shelters in Brussels, Belgium
Authors: Roland Michel , Ben Abdelhafidh Louisa , Déom Victoria , Vanbiervliet Frank , Coppieters Yves , Racapé Judith 
Published: June 2021

Background
Subgroups of precarious populations such as homeless people are more exposed to infection and at higher risk of developing severe forms of COVID-19 compared to the general population. Many of the recommended prevention measures, such as social distancing and self-isolation, are not feasible for a population living in shelters characterised by physical proximity and a high population density. The objective of the study was to describe SARS-CoV-2 infection prevalence in homeless shelters in Brussels (Belgium), and to identify risk factors and infection control practices associated with SARS-CoV-2 positivity rates.

Methods
A total of 1994 adults were tested by quantitative PCR tests in 52 shelters in Brussels (Belgium) between April and June, 2020, in collaboration with Doctors of the World. SARS-CoV-2 prevalence is here described site by site, and we identify risk factors associated with SARS-CoV-2 positivity rates. We also investigate associations between seropositivity and reported symptoms.

Results
We found an overall prevalence of 4.6% for the period, and a cluster of high rates of SARS-CoV-2 positivity (20–30% in two shelters). Among homeless people, being under 40 years of age (OR (CI95%) 2.3 (1.2–4.4), p = 0.02), having access to urgent medical care (AMU) (OR(CI95%): 2.4 (1.4–4.4)], p = 0.02), and sharing a room with someone who tested positive (OR(CI95%): 5.3 (2.9–9.9), p<0.0001) were factors associated with SARS-CoV-2 positivity rates. 93% of those who tested positive were asymptomatic.

Conclusion
This study shows high rates of SARS-COV-2 infection positive tests in some shelters, with a high proportion of asymptomatic cases. The survey reveals how important testing and isolation measures are, together with actions taken by medical and social workers during the outbreak.
Disability, pain, and wound-specific concerns self-reported by adults at risk of limb loss: A cross-sectional study using the World Health Organization Disability Assessment Schedule 2.0
Authors: Roberts Derek J. , Nagpal Sudhir K. , Forster Alan J. , Brandys Timothy , Murphy Christine , Jennings Alison , Strauss Shira A. , Vishnyakova Evgeniya , Lawson Julie , McIsaac Daniel I. 
Published: June 2021

Introduction
There has been limited study of patient-reported outcomes (PROs) in patients at risk of limb loss. Our primary objective was to estimate the prevalence of disability in this patient population using the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0).

Materials and methods
We recruited patients referred to a limb-preservation clinic. Patients self-reported their disability status using the 12-domain WHODAS 2.0. Severity of disability in each domain was scored from 1 = none to 5 = extreme and the total normalized to a 100-point scale (total score ≥25 = clinically significant disability). We also asked patients about wound-specific concerns and wound-related discomfort or distress.

Results
We included 162 patients. Reasons for clinic referral included arterial-insufficient (37.4%), postoperative (25.9%), and mixed etiology (10.8%) wounds. The mean WHODAS 2.0 disability score was 35.0 (standard deviation = 16.0). One-hundred-and-nineteen (73.5%) patients had clinically significant disability. Patients reported they had the greatest difficulty walking a long distance (mean score = 4.2), standing for long periods of time (mean score = 3.6), taking care of household responsibilities (mean score = 2.7), and dealing with the emotional impact of their health problems (mean score = 2.5). In the two-weeks prior to presentation, 87 (52.7%) patients expressed concern over their wound(s) and 90 (55.6%) suffered a moderate amount or great deal of wound-related discomfort or distress. In adjusted ordinary least squares regression models, although WHODAS 2.0 disability scores varied with changes in wound volume (p = 0.03) and total revised photographic wound assessment tool scores (p<0.001), the largest decrease in disability severity was seen in patients with less wound-specific concerns and wound-related discomfort and distress.

Discussion
The majority of people at risk of limb loss report suffering a substantial burden of disability, pain, and wound-specific concerns. Research is needed to further evaluate the WHODAS 2.0 in a multicenter fashion among these patients and determine whether care and interventions may improve their PROs.
Analytical properties of the two-variables Jacobi matrix polynomials with applications
Authors: Abdalla Mohamed , Hidan Muajebah 
Published: June 2021

Abstract
In the current study, we introduce the two-variable analogue of Jacobi matrix polynomials. Some properties of these polynomials such as generating matrix functions, a Rodrigue-type formula and recurrence relations are also derived. Furthermore, some relationships and applications are reported.