bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between pancreatic fibrosis and development of pancreoprivic diabetes after pancreaticoduodenectomy
Authors: Lee Jung Min , Kim Hyung Sun , Lee Minyoung , Park Ho Seon , Kang Shinae , Nahm Ji Hae , Park Joon Seong 
Published: December 2021

AbstractThis study investigated the correlation between pancreatic fibrosis (PF) and development of pancreoprivic diabetes after pancreaticoduodenectomy (PD). Ninety-five patients who underwent PD at Gangnam Severance Hospital between 2014 and 2017 were enrolled. PF grade was evaluated with alpha-smooth muscle actin (SMA) and Masson’s trichrome (TRC) staining. New-onset pancreoprivic diabetes and recurrence of disease were evaluated using fasting blood glucose measurement and radiography taken at 3-month intervals. Sixty-one patients did not have preoperative diabetes, however, 40 (65.6%) patients developed pancreoprivic diabetes after PD. High-grade PF was more common in the diabetes group than in the normal group (SMA, 42.5% vs. 28.6%, P = 0.747; TRC, 47.5% vs. 28.6%, P = 0.361). The 1-year cumulative incidence of hyperglycemia/pancreoprivic diabetes was higher with high-grade PF than low-grade PF (SMA, 94.4% vs. 73.0%, P = 0.027; TRC, 89.3% vs. 75.0%, P = 0.074). The SMA-TRC combined high-grade group had a higher proportion of primary pancreatic disease than the combined low-grade group (90.0% vs. 37.5%, P = 0.001). The 5-year disease-free survival of patients with pancreatic cancer was worse with high-grade PF than low-grade PF (SMA, 24.5% vs. 66.3%, P = 0.026; TRC, 23.6% vs. 58.4%, P = 0.047). In conclusion, patients with severe PF are more likely to develop pancreoprivic diabetes after PD and have worse disease-free survival.
Influence of visual control on the quality of graphic gesture in children with handwriting disorders
Authors: Lopez Clémence , Vaivre-Douret Laurence 
Published: December 2021

AbstractHandwriting disorders (HD) are considered one of the major public health problems among school-aged children worldwide with significant interference on academic performances. The current study hypothesized that HD could be partly explained by a deficit in sensory feedback processing during handwriting. To explore this hypothesis, we have analyzed the effect of vision suppression on postural-gestural and on spatial/temporal/kinematic organization of drawing during an early pre-scriptural loop task with a digital pen, under two conditions: eyes open and eyes closed. Data collected from 35 children with HD were compared to data collected from typical children (typical group) from primary schools. The HD group showed significantly poorer postural control and an improvement on the spatial/temporal/kinematic organization of drawings when they closed their eyes compared to eyes opened. While in the typical group, postural-gestural organization became significantly more mature but there was no significant influence found on spatial/temporal/kinematic parameters of the loops. Thus, handwriting disorders could be explained by both proprioceptive/kinesthetic feedback disabilities and a disruptive effect of the visual control on the quality of the pre-scriptural drawings among these children who have kinesthetic memory and visuospatial disabilities. The ability of directing the strokes would remain dependent on sensory feedbacks, themselves insufficiently efficient, which would lead to difficulties in reaching a proactive control of handwriting. This current research is a liable contribution to enhance clinical practice, useful in clinical decision-making processes for handwriting disorders remediation.
Bioactive cationic peptides as potential agents for breast cancer treatment
Authors: Manrique-Moreno Marcela , Santa-González Gloria A. , Gallego Vanessa 
Published: December 2021

Abstract
Breast cancer continues to affect millions of women worldwide, and the number of new cases dramatically increases every year. The physiological causes behind the disease are still not fully understood. One in every 100 cases can occur in men, and although the frequency is lower than among women, men tend to have a worse prognosis of the disease. Various therapeutic alternatives to combat the disease are available. These depend on the type and progress of the disease, and include chemotherapy, radiotherapy, surgery, and cancer immunotherapy. However, there are several well-reported side effects of these treatments that have a significant impact on life quality, and patients either relapse or are refractory to treatment. This makes it necessary to develop new therapeutic strategies. One promising initiative are bioactive peptides, which have emerged in recent years as a family of compounds with an enormous number of clinical applications due to their broad spectrum of activity. They are widely distributed in several organisms as part of their immune system. The antitumoral activity of these peptides lies in a nonspecific mechanism of action associated with their interaction with cancer cell membranes, inducing, through several routes, bilayer destabilization and cell death. This review provides an overview of the literature on the evaluation of cationic peptides as potential agents against breast cancer under different study phases. First, physicochemical characteristics such as the primary structure and charge are presented. Secondly, information about dosage, the experimental model used, and the mechanism of action proposed for the peptides are discussed.
Type identification and time location of multiple power quality disturbances based on KF‐ML‐aided DBN
Authors: Xi Yanhui , Chen Zixuan , Tang Xin , Li Zewen , Zeng Xiangjun 
Published: December 2021

AbstractType identification and time location of power quality disturbances (PQDs) is the key to adopting corresponding measures to suppress disturbances. More complex multiple disturbances caused by the overlapping of different micro‐grids make it a challenging task. The paper proposes a hybrid approach combing KF‐ML (Kalman filter based on maximum likelihood) with deep belief network (DBN) for dealing with PQDs. To be specific, the KF‐ML is firstly applied to reduce noise from the original distorted signal, and the innovation sequence obtained by KF‐ML can be used to locate starting–ending times of PQDs. Then, the DBN, which fuses feature extraction and classification into a single block, is capable of recognizing the type of PQDs accurately. To verify the effectiveness of the proposed method, 20 classes of PQDs with noise interference are tested, and experiment results show that the detection time of the proposed method is very close to the set time, and the absolute error of time location is less than 0.3 ms. The average classification accuracy at different noise levels reaches about 95%, and is very high even with more disturbances combined. Thus, the proposed method is immune to noise and less affected with more disturbances combined relative to other methods.
Dynamic modelling and optimal control of virtual power plant driven by commercial HVACs
Authors: Gao Ciwei , Song Meng , Ma Sisi , Guo Mingxing , Lv Ran , Fei Fei 
Published: December 2021

AbstractHeating, ventilation, and air conditionings (HVACs) of commercial buildings bear a large amount of weight in total load and have emerged as a major flexible resource participating in power systems. HVACs can be aggregated in an entity to participate in power system dispatching. First, refrigeration and air systems modelling of HVACs is conducted. Second, commercial buildings with HVACs are encapsulated into a power‐smoothed and independent virtual generation unit (VGU) by using an internal integrated coordination control method, which characterizes the virtual generation capability of commercial buildings. Third, the dynamic modelling method of virtual power plant (VPP) is presented, and a local‐autonomous optimal control strategy of HVACs is proposed via centralized‐distributed architectures. The results of the analysis indicate that HVACs can be adequately regulated to participate in power system peak‐shaving.
Zeeman-Doppler imaging of five young solar-type stars
Authors: Willamo T. , Lehtinen J. J. , Hackman T. , Käpylä M. J. , Kochukhov O. , Jeffers S. V. , Korhonen H. , Marsden S. C. 
Published: December 2021

Context. The magnetic activity of the Sun changes with the solar cycle. Similar cycles are found in other stars as well, but their details are not known to a similar degree. Characterising stellar magnetic cycles is important for the understanding of the stellar and solar dynamos that are driving the magnetic activity.
Aims. We present spectropolarimetric observations of five young, solar-type stars and compare them to previous observations, with the aim to identify and characterise stellar equivalents of the solar cycle.
Methods. We use Zeeman-Doppler imaging (ZDI) to map the surface magnetic field and brightness of our targets. The magnetic field is decomposed into spherical harmonic expansions, from which we report the strengths of the axisymmetric versus non-axisymmetric and poloidal versus toroidal components, and we compare them to the Rossby numbers of the stars.
Results. We present five new ZDI maps of young, solar-type stars from December 2017. Of special interest is the case of V1358 Ori, which had gone through a polarity reversal between our observations and earlier ones. A less evident polarity reversal might also have occurred in HD 35296. There is a preference for a more axisymmetric field, and possibly a more toroidal field, for the more active stars with lower Rossby number, but a larger sample should be studied to draw any strong conclusions from this. For most of the individual stars, the amounts of toroidal and poloidal field have stayed on levels similar to those in earlier observations.
Conclusions. We find evidence for a magnetic polarity reversal having occurred in V1358 Ori. An interesting target for future observations is χ1 Ori, which may have a short magnetic cycle of a few years. The correlation between the brightness maps and the magnetic field is mostly poor, which could indicate the presence of small-scale magnetic features of different polarities that cancel one another out and are thus not resolved in our maps.
Neurodegenerative Erkrankungen – ganzheitliches Therapiekonzept mit funktioneller Ernährungsmedizin
Authors: Böhm Udo 
Published: December 2021

ZusammenfassungNeurodegenerative Erkrankungen sind in westlichen Gesellschaften auf dem Vormarsch. Sie entwickeln sich langsam und werden durch ein Zusammenspiel verschiedener Faktoren verursacht, wobei der Lebensstil und die Versorgung mit essenziellen Mikronährstoffen eine tragende Rolle spielen. Die wichtigsten der heute diskutierten Risikofaktoren und Trigger für die Entstehung und das Fortschreiten neurodegenerativer Erkrankungen werden vorgestellt sowie ihre Auswirkungen auf den gesamten Stoffwechsel und die Resilienz des Organismus. Der Beitrag konzentriert sich aufgrund der Vielfalt neurodegenerativer Erkrankungen auf das Gesamtkonzept aus Ursachenergründung und ganzheitlichen präventiven oder therapeutischen Maßnahmen. In der Praxis können direkt umsetzbare Möglichkeiten zur Stärkung der körpereigenen Ressourcen sowie zur Prävention und Therapie von neurodegenerativen Erkrankungen unter ganzheitlichen Gesichtspunkten mit Schwerpunkt auf Lebensstil-, Umwelt- und funktionelle Ernährungsmedizin angewendet werden.
Die Behandlung des M. Parkinson aus der Perspektive der Āyurveda-Medizin
Authors: Chopra Ananda Samir 
Published: December 2021

ZusammenfassungĀyurveda bietet vielfältige wirksame Behandlungsansätze zur Behandlung des idiopathischen Parkinson-Syndroms. Da es in der klassischen āyurvedischen Literatur keine direkte Entsprechung zum modern definierten Krankheitsbild des M. Parkinson gibt, muss man stets eine individuelle Einschätzung von Krankheit und Konstitution des jeweiligen Patienten nach āyurvedischen Kriterien vornehmen. Aus āyurvedischer Sicht liegt beim Parkinson-Syndrom vor allem eine Vāta-Störung sowie eine Schwäche der Verdauungskraft vor. Aufgrund dieser Einschätzung erfolgt dann eine individuelle Therapie. Der erste Schritt in der āyurvedischen Behandlung besteht aus Empfehlungen zu Ernährung und Lebensweise.Darüber hinaus verfügt der Āyurveda über eine reiche Arzneimittelkunde, insbesondere pflanzliche Arzneien. Im Zusammenhang mit der Behandlung des M. Parkinson haben die Samen der Juckbohne (Mucuna pruriens) eine gewisse Prominenz erlangt, da sie unter anderem L-Dopamin enthalten. Auch das Pañcakarma-Therapieverfahren, ein komplexes āyurvedisches Therapieverfahren aus ausleitenden und krankheitsbesänftigenden Therapieansätzen, bewährt sich in der Behandlung des M. Parkinson.
Der Einsatz von Homöopathie in der Psychiatrie
Authors: Hock Nikolaus 
Published: December 2021

SummaryHomöopathische Mittel kommen nicht nur bei physischen Beschwerden, sondern auch bei psychischen Erkrankungen zum Einsatz. Die Wahl des homöopathischen Arzneimittels orientiert sich an den Symptomen. Voraussetzung für eine sinnvolle homöopathische Behandlung ist die ausreichende Fachkenntnis des Arztes sowie die Krankheitseinsicht des Patienten. Forschung und Praxis zeigen, dass homöopathische Mittel selbst bei wiederkehrenden Beschwerden und Arzneimittelresistenz einen positiven Effekt auf den Krankheitsverlauf bewirken können.
Akupunktur in der Psychiatrie – Chancen und Grenzen
Authors: Musil Richard , Hofer Eva-Maria , Colling Christoph 
Published: December 2021

SummaryAkupunktur wird in zunehmendem Umfang an deutschen psychiatrischen Kliniken angeboten. Die Evidenz in der publizierten Literatur hat über die letzten Jahre deutlich zugenommen. Die Qualität der Studien muss sich allerdings weiterhin verbessern, um zu klaren Ergebnissen und Empfehlungen in Metaanalysen zu kommen. Insbesondere bei depressiven Erkrankungen und Traumafolgestörungen könnte Akupunktur durch seine Nebenwirkungsarmut in Zukunft einen größeren Stellenwert gewinnen. Akupunktur lässt sich in unterschiedliche Behandlungsstrategien relativ einfach integrieren. Eine große Hürde stellt allerdings die geringe Verbreitung einer ausreichenden Ausbildung bei Behandlern in psychiatrischen und psychosomatischen Kliniken dar.
Präsentation von Palliativstationen und SAPV-Teams im Internet – eine korpusbasierte Metaanalyse von Webseiten
Authors: Peters Joachim , Dykes Natalie , Heckel Maria , Ostgathe Christoph , Habermann Mechthild 
Published: December 2021

Zusammenfassung
Hintergrund Internetseiten stellen eine wichtige Säule in der Darstellungs- und Informationspolitik palliativmedizinischer Angebote dar. Sie fungieren als Anlaufstelle für Patienten und Angehörige, aber auch für medizinisch interessierte Laien.
Methoden Es wurden 488 auf dem Wegweiser Palliativmedizin (Stand 31.7.2019) verlinkte Webseiten untersucht (242 Palliativstationen; 246 SAPV-Teams). Die Selbstdarstellung von palliativmedizinischen Versorgungsangeboten auf Webseiten wurde unter Einsatz von Keyword-Recherchen und manueller Suchanfragen analysiert.
Ergebnisse Palliativmedizinische Webseiten stellen das Konzept von Palliativversorgung im Allgemeinen dar, umreißen den Anwendungsbereich palliativen Handelns, nennen wichtige Erkrankungen und Symptome und heben die Besonderheiten des eigenen Angebots hervor. Die Webseiten der SAPV und der Palliativstationen unterscheiden sich im Hinblick auf ihre Selbstdarstellung und auf die Darstellung der eigenen Professionalität.
Diskussion Eine inhaltliche Verengung der Webseiten auf Krebserkrankungen und die Symptome Schmerz, Luftnot und Übelkeit/Erbrechen spiegelt nicht die aktuelle fachliche Diskussion über u. a. neurodegenerative Erkrankungsbilder und psychosoziale Symptome wider.
Schlussfolgerung Die Webseiten könnten dahingehend ergänzt werden, Patienten und Angehörigen das Wiedererkennen ihrer eigenen Situation zu ermöglichen und das Aufgabenfeld der Palliativversorgung umfassender abzubilden.
An Approach to the Synthesis of a Hepatitis C Virus Inhibitor through a Proline-Catalyzed 1,3-Dipolar Cycloaddition Using Acrolein
Authors: Carrillo Luisa , Vicario Jose L. , Ugarriza Iratxe , Reyes Efraím , Prieto Liher , Uria Uxue 
Published: December 2021

AbstractAn efficient and easy protocol for performing 1,3-dipolar cycloaddition using azomethine ylides and acrolein is presented. The reaction catalyzed by d-proline allows the synthesis of C-3 unsubstituted pyrrolidines. The application of this methodology to the synthesis of an advanced intermediate in the preparation of a Hepatitis C virus inhibitor is presented. Final attempts to complete the synthesis of the target inhibitor results in the preparation of its C-4 epimer in good overall yield.
Complementary and Alternative Medicine Attitudes of Gynecologic Patients: Experience in a Tertiary Clinic
Authors: Yorgancı Ayçağ , Öztürk Uğur Kemal , Evliyaoğlu Bozkurt Özlem , Akyol Mesut , Pay Ramazan Erda , Engin-Ustun Yaprak 
Published: December 2021

Abstract
Objective To evaluate the knowledge, attitudes, and behaviors regarding complementary and alternative medicine methods of patients who were admitted to gynecology outpatient clinics.
Methods In the present survey, a questionnaire on complementary and alternative medicine practices was applied on 1,000 women (ages between 18 and 83 years old) who were admitted to the gynecology outpatient clinic of a tertiary maternity hospital. Demographic features and knowledge, attitudes, and behaviors about these methods were inquired in face-to-face interviews.
Results While 80.7% of the total participants thought that complementary and alternative medicine was beneficial, only 37.5% of them had used these methods previously. The rate of prior knowledge on this subject was of 59.7% and the source of information was physicians for 8.5% of the patients. However, 72.4% of all participants wanted to obtain information on these methods and 93.7% wanted to be informed by physicians. In the decision tree model, having knowledge about complementary and alternative medicine was the most effective factor determining its use (p < 0.001). Phytotherapy was found to be the most used method, with 91.4%. The most preferred plant was onion (18.9%), and the most common reasons for herbal use were stress (15.4%) and fatigue (15.2%).
Conclusion More than one-third of the patients who applied to the gynecology outpatient clinics used one of the complementary and alternative medicine methods at least once. As gynecologists and obstetricians, we need to be more knowledgeable about these methods to provide correct guidance to our patients for accessing accurate and effective information.
Polarized information ecosystems can reorganize social networks via information cascades
Authors: Tokita Christopher K. , Guess Andrew M. , Tarnita Corina E. 
Published: December 2021

SignificanceMany argue that partisan media coverage creates political polarization by pushing people’s opinions to extremes, but evidence is mixed. We instead propose that partisan media coverage can cause polarization by altering people’s social connections and reorganizing social networks along political lines. Using computational modeling and social media data, we explore how people may adjust their social ties to avoid the sharing behavior of friends who might be engaging with news from nonpreferred information sources. Our model suggests that polarization is driven to a large extent by unfollowing, which can gradually—and inadvertently—produce homogeneous online networks, known to reduce exposure to challenging information and encourage outgroup hostility. In this way, institutional polarization can reverberate through the networked mass public.
Segregation and clustering of preferences erode socially beneficial coordination
Authors: Vasconcelos Vítor V. , Constantino Sara M. , Dannenberg Astrid , Lumkowsky Marcel , Weber Elke , Levin Simon 
Published: December 2021

Significance
With different types and manifestations of polarization growing, it is crucial to understand their impact on welfare-promoting processes in society. This understanding is important when polarization interrupts both socially and individually optimal outcomes. We propose a model and framework to study and quantify the relationship between polarization and the ability to coordinate. We show, analytically, that some degree of diversity of opinions may be beneficial to coordination. Then, we explore, both computationally and through experiments, the role that properties of networks, namely segregation and biased perceptions, play in eroding coordination and moving societies away from the social optimum. We expect this work to provide the basis for upcoming research on the connection between the polarization of opinions and social outcomes.
How can register analysis inform task-based language teaching?
Authors: Crawford William J. , Zhang Meixiu 
Published: December 2021

Abstract
For over 30 years, corpus research on register variation has expanded our understanding of language use by
illustrating how linguistic features co-occur and vary in different situations of use (Biber
& Conrad 2019). Over the same period, Task-based Language Teaching (TBLT) has provided a theoretical and empirical
basis for research in instructed Second Language Acquisition/SLA (Ellis 2012). This paper
illustrates how the methods and approaches used in register analysis offer a useful framework for understanding critical issues in
TBLT (e.g., describing tasks and interpreting task performance). The paper compares register analysis and TBLT and then draws upon
recent empirical work demonstrating how a register approach (a) identifies a wider range of linguistic and non-linguistic variables
than are generally in TBLT; and, (b) provides a useful framework to functionally interpret task performance. The paper ends by
discussing how a register perspective can benefit future areas of investigation in task-based second language research.
The impact of climate change on the biology of the cattle tick, Rhipicephalus microplus: current knowledge and gaps to be filled.
Authors: Santos Isabel , Szabó Matias Pablo Juan , Caetano Alexandre Rodrigues , de Camargo Maristela Martins 
Published: December 2021

Abstract

This expert opinion revisits the factors affecting the on- and off-host ecology of Rhipicephalus microplus in the context of climate change. It also highlights how the negative effects of heat stress caused by climate change on animal welfare, productivity and health of cattle will likely become more of an issue in the future if the Earth's climate continues to warm as predicted.
Effects of climate change on babesiosis vectors.
Authors: Gray Jeremy 
Published: December 2021

Abstract

This chapter discusses the impact of climate change on the abundance and distribution of babesiosis vectors and, by implication, transmission of Babesia spp. It discusses evidence for climate change impact on the vectors Ixodes ricinus, Dermacentor reticulatus, Haemaphysalis punctata and Hyalomma spp. as well as the absence of evidence of the same climate change effects on the vectors Rhipicephalus spp. and I. scapularis.
Revisiting cosmologies in teleparallelism
Authors: D’Ambrosio Fabio , Heisenberg Lavinia , Kuhn Simon 
Published: December 2021

AbstractWe discuss the most general field equations for cosmological spacetimes for theories of gravity based on non-linear extensions of the non-metricity scalar and the torsion scalar. Our approach is based on a systematic symmetry-reduction of the metric-affine geometry which underlies these theories. While for the simplest conceivable case the connection disappears from the field equations and one obtains the Friedmann equations of general relativity, we show that inf(Q)cosmology the connection generically modifies the metric field equations and that some of the connection components become dynamical. We show thatf(Q)cosmology contains the exact general relativity solutions and also exact solutions which go beyond. Inf(T)cosmology, however, the connection is completely fixed and not dynamical.