bluuebunny/crossref_metadata_2025_split huggingface dataset:
Networks of Care: A Social Network Perspective of Distributed Multidisciplinary Care for People With Inflammatory Arthritis
Authors: Hartford Wendy , Backman Catherine L. , Li Linda C. , McQuitty Shanon , McKinnon Annette , Kherani Raheem , Nimmon Laura 
Published: October 2021

ObjectiveTo explore how multidisciplinary inflammatory arthritis (IA) care is accessed from the perspectives of people with IA and their health care network members.MethodsIn this phenomenological study, we used purposive sampling to recruit patients with IA for less than 5 years and age of more than 18 years who spoke English and reported two or more health care network members. We conducted one‐to‐one interviews with patients and their health care network members. Data were analysed using a social network perspective.ResultsWe interviewed 14 patient participants and 19 health care network members comprising health care providers and informal caregivers. An overarching theme of whole person (holistic) IA care was identified, with the following two broad multifaceted subthemes: 1) connected networks and whole person care and 2) network disconnect and disrupted access to care. The first subtheme notes how access to health care providers and social support was fundamental to holistic care and how care was facilitated by communication pathways that promoted care. The second subtheme illustrates impediments to access, including appointment time pressures, inadequacies in communication delivery modes, and family physicians’ unfamiliarity with rheumatology care. Inequities in care were also reported.ConclusionParticipants shared a goal of whole person care. Although health care networks included multiple disciplines, they did not always provide coordinated multidisciplinary care. Communication modes, linkages between network actors, and organizational structures governed the flow of information and resources through networks and influenced access to equitable whole person care. The development of health care system structures to support the flow of information and resource transfer is needed to promote network collaboration and equitable access to resources.
Achieving Super Broadband Electromagnetic Absorption by Optimizing Impedance Match of rGO Sponge Metamaterials
Authors: Sun Xianxian , Li Yibin , Huang Yixing , Cheng Yuanjing , Wang Shasha , Yin Weilong 
Published: October 2021

AbstractThe reduced graphene oxide (rGO) sponges exhibit exciting electromagnetic absorption (MA) performance in high‐frequency range. However, it is still a great challenge to realize desirable MA property at low frequency (2–4 GHz) due to the great difficulty in balancing the good interfacial impedance matching and strong dielectric loss. Herein, the MA metamaterials based on rGO sponge with different unit shapes are reported. The relationship between the unit shape and MA performance is explored by experiment and simulation. The results show that frustum pyramid metamaterial exhibits ultrabroad band MA; the qualified absorption (the reflection loss lower than −10 dB) of electromagnetic wave can be achieved at 2.4–40 GHz. The average absorption intensity is −22.9 dB in the band of 2–40 GHz. Moreover, the bandwidth for strong absorption with an absorption rate of 99% (−20 dB) is up to 32 GHz. It is significant that the reflection loss has ignorant change even though the incident angle is increased from 5° to 40°. These are contributed to the excellent impedance matching and strong dielectric loss. These lightweight frustum pyramid metamaterials are very promising in the application for broadband electromagnetic protection.
Universal Existence of Localized Single‐Photon Emitters in the Perovskite Film of All‐Inorganic CsPbBr3 Microcrystals
Authors: Feng Shengnan , Qin Qilin , Han Xiaopeng , Zhang Chunfeng , Wang Xiaoyong , Yu Tao , Xiao Min 
Published: October 2021

AbstractAll‐inorganic halide perovskites have drawn a lot of research attention very recently owing to their potential solution to the instability issue currently faced by the organic–inorganic counterparts. Meanwhile, the halide perovskites in a solid film are manifested as microscale morphologies whose functionalities are unavoidably affected by the interior or exterior presence of various nanoscale entities. Here all‐inorganic solid films are fabricated with varying densities of single CsPbBr3 microcrystals, showing that very sharp photoluminescence peaks can be universally observed at 4 K with the linewidths being as narrow as hundreds of μeV. The single‐photon emission nature is confirmed for such a photoluminescence peak, whose intensity is completely quenched above ≈30 K to suggest its possible origin from a low potential‐energy region of the single microcrystal. The discovery of such a novel emitting species in halide perovskites, with the enriched structure–property relationship, will surely impart significant influences on the advancement of relevant optoelectronic devices and quantum‐light sources.
Spatiotemporally Controllable Distribution of Combination Therapeutics in Solid Tumors by Dually Modified Bacteria
Authors: Wang Lu , Cao Zhenping , Zhang Mengmeng , Lin Sisi , Liu Jinyao 
Published: October 2021

AbstractMethods capable of distributing antitumor therapeutics uniformly and durably throughout an entire tumor would be of great significance in maximizing their treatment efficacy, but they have proven to be extremely challenging. Here, bacteria‐mediated spatiotemporally controllable distribution of combination therapeutics in solid tumors is reported to reprogram the immune microenvironment for optimizing antitumor efficacy. By combining synthetic biology and interfacial chemistry, bacteria are inside and outside concurrently modified to express photothermal melanin and to attach immune checkpoint inhibitors on their surface. Due to the nature of bacteria to colonize the hypoxia intratumoral environment, both therapeutic agents can be distributed homogenously and lastingly in tumors during ex vivo human and in vivo mouse studies. Spatiotemporally controllable localization of melanin can repeatedly generate a moderate yet uniform heating of the tumor upon light exposure in a broad treatment window. Combination with similarly localized inhibitors elicits a dual photothermally stimulated and checkpoint‐blockade‐mediated immune activation effect, synergistically reprogramming the immunosuppressive tumor microenvironment. Therapeutic values are demonstrated by significantly inhibited tumor growth and prolonged survival of mice in both subcutaneous and orthotopic murine models. Colonization of dually modified bacteria paves an avenue for spatiotemporally controllable distribution of therapeutic drugs in solid tumors.
Prediction of Nanoparticle Sizes for Arbitrary Methacrylates Using Artificial Neuronal Networks
Authors: Kimmig Julian , Schuett Timo , Vollrath Antje , Zechel Stefan , Schubert Ulrich S. 
Published: October 2021

AbstractParticle sizes represent one of the key factors influencing the usability and specific targeting of nanoparticles in medical applications such as vectors for drug or gene therapy. A multi‐layered graph convolutional network combined with a fully connected neuronal network is presented for the prediction of the size of nanoparticles based only on the polymer structure, the degree of polymerization, and the formulation parameters. The model is capable of predicting particle sizes obtained by nanoprecipitation of different poly(methacrylates). This includes polymers the network has not been trained with, indicating the high potential for generalizability of the model. By utilizing this model, a significant amount of time and resources can be saved in formulation optimization without extensive primary testing of material properties.
Liquid Crystalline Rylenediimides with Highly Order Smectic Layer Structure as a Floating Gate for Multiband Photoresponding Photonic Transistor Memory
Authors: Lin Yi‐Sa , Lin Yan‐Cheng , Yang Wei‐Chen , Li Guan‐Syuan , Ercan Ender , Hung Chih‐Chien , Chien Wen‐Chen , Chen Wen‐Chang 
Published: October 2021

AbstractWith the growing demands of light fidelity technology, photonic transistor memory has gained considerable attention for next‐generation optoelectronic devices. In this work, alkylated rylenediimides of 2,9‐diphenethylanthra[2,1,9‐def:6,5,10‐d“e”f]diisoquinoline‐1,3,8,10(2H,9H)‐tetraone (C8‐PDI) and 2,7‐dioctylbenzo[lmn][3,8]phenanthroline‐1,3,6,8(2H,7H)‐tetraone (C8‐NDI), and pyromellitic diimide of 2,6‐dioctylpyrrolo[3,4‐f]isoindole‐1,3,5,7(2H,6H)‐tetraone (C8‐PMDI) have been used as floating gate electrets in the photonic field‐effect transistor‐type memory. The structure‐optics‐performance relationship of these rod‐like molecules has been systematically studied, and the memory device exhibited a decent response to photowriting and electrical erasing processes, owing to the 3D ordered smectic layer structure and brickwork stacking. Therefore, an evenly distributed photogating moiety, efficient exciton dissociation associated with decent carrier tunneling and charge trapping can be obtained. Among them, the sought‐after C8‐NDI presents favorable energy level alignment, multiband photoresponding, and an optimal block ratio. The fabricated photonic memory with C8‐NDI electret presented a remarkable memory switchability with a memory ratio of 104 and a stable memory ratio of 105 over 10,000 s. To the best of knowledge, this is the first work to utilize rylenediimides based liquid crystals as an efficient charge blocking electret, and these findings open an avenue for designing rod‐like molecules with highly ordered liquid crystalline properties in the ultrafast photomemory devices.
The relationship of cold acclimation and extracellular ice formation to winter thermonasty in twoRhododendronspecies and their F1hybrid
Authors: Arora Rajeev , Krebs Stephen L. , Wisniewski Michael E. 
Published: October 2021

AbstractPremiseThermonastic leaf movements in evergreenRhododendronspecies have been used to study plant strategies for winter photoprotection. To add to the current fundamental understanding of this behavior, we addressed the following questions: (1) Is the cold‐acclimated (CA) state necessary for thermonasty, and do cold‐induced leaf movements also occur in non‐acclimated (NA) plants? (2) Which of the two movements, leaf rolling versus curling, is more responsive to freezing, if any, in a non‐thermonastic species? (3) What is the temporal relationship between extracellular freezing and thermonasty? (4) What genetic inferences can be drawn from leaf movement in an F1hybrid relative to its parents?MethodsA temperature‐controlled, gradual cooling regime was used to quantify freeze‐induced leaf movements. Infrared thermography was used to confirm extracellular ice‐formation in leaves.ResultsBoth NA and CA plants of thermonastic species exhibited thermonasty, but leaf rolling/curling increased significantly in CA plants. In the cold‐acclimated condition, a non‐thermonastic species showed almost no rolling during freezing, while the thermonastic species and F1hybrid did, the latter exhibiting a response intermediate to the parents. Freezing‐induced leaf curling in the non‐thermonastic species and the F1hybrid was equivalent and significantly less than the degree of curling in the thermonastic species.ConclusionsMilder thermonasty in NA than CA leaves could be associated with differential anisotropy in the rolling forces and/or response of aquaporins to freezing. Leaf movements in the hybrid suggest that leaf rolling and curling are additive and dominant genetic traits, respectively. Infrared thermography confirms that ice formation in tissues precedes cold‐induced thermonasty inR. catawbiense.
Late‐onset hematological complications post COVID‐19: An emerging medical problem for the hematologist
Authors: Korompoki Eleni , Gavriatopoulou Maria , Fotiou Despina , Ntanasis‐Stathopoulos Ioannis , Dimopoulos Meletios A. , Terpos Evangelos 
Published: October 2021

AbstractCoronavirus disease 19 (COVID‐19) is considered a multisystemic disease. Several studies have reported persistent symptoms or late‐onset complications after acute COVID‐19, including post‐COVID‐19 hematological disorders. COVID‐19‐induced coagulopathy, an immunothrombotic state, has been linked to thromboembolic and hemorrhagic events. Late‐onset thrombocytopenia related to immune system dysregulation has also been reported as a rare manifestation post COVID‐19. Close monitoring of laboratory dynamics is considered essential to identify timely abnormal values that need further investigation, providing supportive care whenever indicated. The role of hematologists is essential in terms of the multidisciplinary approach of long COVID‐19. This review summarizes all the available evidence on post‐acute COVID‐19 hematological complications.
Describing economic benefits and costs of nonstandard work hours: A scoping review
Authors: Wong Imelda S. , Quay Brian , Irvin Emma , Belzer Michael H. 
Published: October 2021

AbstractBackgroundThe benefits of nonstandard work hours include increased production time and the number of jobs. While for some sectors, such as emergency services, around‐the‐clock work is a necessary and critical societal obligation, work outside of traditional daytime schedules has been associated with many occupational safety and health hazards and their associated costs. Thus, organizational‐ and policy‐level decisions on nonstandard work hours can be difficult and are based on several factors including economic evaluation. However, there is a lack of systematic knowledge of economic benefits and costs associated with these schedules.MethodsWe conducted a scoping review of the methodology and data used to examine the economic benefits and costs of nonstandard work hours and related interventions to mitigate risks.ResultsTen studies met all our inclusion criteria. Most studies used aggregation and analysis of national and other large datasets. Costs estimated include health‐related expenses, productivity losses, and projections of future loss of earnings. Cost analyses of interventions were provided for an obstructive sleep apnea screening program, implementation of an employer‐based educational program, and increased staffing to cover overtime hours.ConclusionsA paucity of studies assess nonstandard work hours using economic terms. Future studies are needed to expand economic evaluations beyond the employer level to include those at the societal level because impacts of nonstandard work go beyond the workplace and are important for policy analysis and formulation. We pose the opportunity for researchers and employers to share data and resources in the development of more analyses that fill these research gaps.
COVID‐19 Vaccine Response in People with Multiple Sclerosis
Authors: Tallantyre Emma C. , Vickaryous Nicola , Anderson Valerie , Asardag Aliye Nazli , Baker David , Bestwick Jonathan , Bramhall Kath , Chance Randy , Evangelou Nikos , George Katila , Giovannoni Gavin , Godkin Andrew , Grant Leanne , Harding Katharine E. , Hibbert Aimee , Ingram Gillian , Jones Meleri , Kang Angray S. , Loveless Samantha , Moat Stuart J. , Robertson Neil P. , Schmierer Klaus , Scurr Martin J. , Shah Sita Navin , Simmons Jessica , Upcott Matthew , Willis Mark , Jolles Stephen , Dobson Ruth 
Published: October 2021

ObjectiveThe purpose of this study was to investigate the effect of disease modifying therapies on immune response to severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) vaccines in people with multiple sclerosis (MS).MethodsFour hundred seventy‐three people with MS provided one or more dried blood spot samples. Information about coronavirus disease 2019 (COVID‐19) and vaccine history, medical, and drug history were extracted from questionnaires and medical records. Dried blood spots were eluted and tested for antibodies to SARS‐CoV‐2. Antibody titers were partitioned into tertiles with people on no disease modifying therapy as a reference. We calculated the odds ratio of seroconversion (univariate logistic regression) and compared quantitative vaccine response (Kruskal Wallis) following the SARS‐CoV‐2 vaccine according to disease modifying therapy. We used regression modeling to explore the effect of vaccine timing, treatment duration, age, vaccine type, and lymphocyte count on vaccine response.ResultsCompared to no disease modifying therapy, the use of anti‐CD20 monoclonal antibodies (odds ratio = 0.03, 95% confidence interval [CI] = 0.01–0.06, p < 0.001) and fingolimod (odds ratio = 0.04; 95% CI = 0.01–0.12) were associated with lower seroconversion following the SARS‐CoV‐2 vaccine. All other drugs did not differ significantly from the untreated cohort. Both time since last anti‐CD20 treatment and total time on treatment were significantly associated with the response to the vaccination. The vaccine type significantly predicted seroconversion, but not in those on anti‐CD20 medications. Preliminary data on cellular T‐cell immunity showed 40% of seronegative subjects had measurable anti‐SARS‐CoV‐2 T cell responses.InterpretationSome disease modifying therapies convey risk of attenuated serological response to SARS‐CoV‐2 vaccination in people with MS. We provide recommendations for the practical management of this patient group. ANN NEUROL 20219999:n/a–n/a
Highly Ethylene‐Selective Electrocatalytic CO2 Reduction Enabled by Isolated Cu−S Motifs in Metal–Organic Framework Based Precatalysts
Authors: Wen Chun Fang , Zhou Min , Liu Peng Fei , Liu Yuanwei , Wu Xuefeng , Mao Fangxin , Dai Sheng , Xu Beibei , Wang Xue Lu , Jiang Zheng , Hu P. , Yang Shuang , Wang Hai Feng , Yang Hua Gui 
Published: October 2021

AbstractCopper‐based materials are efficient electrocatalysts for the conversion of CO2 to C2+ products, and most these materials are reconstructed in situ to regenerate active species. It is a challenge to precisely design precatalysts to obtain active sites for the CO2 reduction reaction (CO2RR). Herein, we develop a strategy based on local sulfur doping of a Cu‐based metal–organic framework precatalyst, in which the stable Cu−S motif is dispersed in the framework of HKUST‐1 (S‐HKUST‐1). The precatalyst exhibits a high ethylene selectivity in an H‐type cell with a maximum faradaic efficiency (FE) of 60.0 %, and delivers a current density of 400 mA cm−2 with an ethylene FE up to 57.2 % in a flow cell. Operando X‐ray absorption results demonstrate that Cuδ+ species stabilized by the Cu−S motif exist in S‐HKUST‐1 during CO2RR. Density functional theory calculations indicate the partially oxidized Cuδ+ at the Cu/CuxSy interface is favorable for coupling of the *CO intermediate due to the modest distance between coupling sites and optimized adsorption energy.
Be–Be π‐Bonding and Predicted Superconductivity in MBe2 (M=Zr, Hf)
Authors: Goesten Maarten G. 
Published: October 2021

AbstractBeryllium, an s‐block element, forms an aromatic network of delocalized Be–Be π bonds in alloys ZrBe2 and HfBe2. This gives rise to stacked [Be2]4− layers with tetravalent cations in between. The [Be2]4− sublattice is isoelectronic and isostructural to graphite, as well as the [B]−2 sublattice in MgB2, and it bears identical manifestations of π bonding in its electronic band structure. These come in the form of degeneracies at K and H in the Brillouin zone, separated in energy as the result of interlayer orbital interactions. Zr and Hf use their valence d orbitals to form bonds with the layers, leading to nearly identical band structures. Like MgB2, ZrBe2 and HfBe2 are computed to be phonon‐mediated superconductors at ambient pressures, with respective critical temperatures of 11.4 K and 8.8 K. The coupling strength between phonons and free electrons is very similar, so that the difference in critical temperatures is controlled by the mass of constituent interlayer ions.
Polyoxymethylene/talc composite: Investigation of warpage, mechanical and thermal properties for thin walled‐injection molding applications
Authors: Kailasanathan Chidambara Kuttalam , Saravanan Salem Thangavel , Natarajan Elango , Stalin Balasubramaniam 
Published: October 2021

AbstractThe warpage in injection‐molded thin‐walled components is a research challenge for many years. Polyoxymethylene (POM) composite was prepared with various weight fractions of talc to investigate the reduction in warpage and its effect on mechanical properties such as tensile, compressive, impact, and thermal properties like Vicat softening point and heat deflection temperature (HDT). The uniform distribution of talc fillers is confirmed in Fourier transform infrared (FTIR) examinations. The talc is found to act as a nucleation agent and affect the crystallinity of POM. It is found from differential scanning calorimetry (DSC) analysis that the percentage of crystallinity is increased with respect to the weight percent of talc fillers and reached a minimum at POM/1 wt% and maximum at POM/3 wt% Talc. The 12% of reduction in warpage is observed in POM/1 wt% Talc polymer composite but it has a 45% increase in impact strength, though it loses the tensile, compressive, and thermal properties by 2%–3%. Meanwhile, the superior mechanical properties are observed in POM/3 wt% Talc polymer composite, but with more warpage than other samples. The present study revealed that the composite with 1% wt loading is suitable to high impact application with lower warpage in thin‐walled molding. The DSC, scanning electron microscopic, X‐ray diffraction, FTIR, HDT, and Vicat softening point results are presented to support the investigations.
PROTOCOL: Effectiveness of interventions for improving educational outcomes for people with disabilities in low‐ and middle‐income countries: A systematic review
Authors: Hunt Xanthe , Saran Ashrita , White Howard , Kuper Hannah 
Published: October 2021

AbstractThe objectives of this review are to answer the following research questions: (1) What is the nature of the interventions used to support education for people with disabilities? (2) What is the size and quality of the evidence base of the effectiveness of interventions to improve educational outcomes for people with disabilities in low‐ and middle‐income countries (LMICs)? (3) What works to improve educational outcomes for people with disabilities in LMICs? (4) Which interventions appear most effective for different types of disability? (5) What are the barriers and facilitators to improving of educational outcomes for people with disabilities? Is there evidence of cumulative effects—that certain interventions are effective when done in combination with others, but are less or ineffective when done alone?
Synthesis and Biological Evaluation of Dithiobisacetamides as Novel Urease Inhibitors
Authors: Liu Mei‐Ling , Li Wei‐Yi , Fang Hai‐Lian , Ye Ya‐Xi , Li Su‐Ya , Song Wan‐Qing , Xiao Zhu‐Ping , Ouyang Hui , Zhu Hai‐Liang 
Published: October 2021

AbstractThirty‐eight disulfides containing N‐arylacetamide were designed and synthesized in an effort to develop novel urease inhibitors. Biological evaluation revealed that some of the synthetic compounds exhibited strong inhibitory potency against both cell‐free urease and urease in intact cell with low cytotoxicity to mammalian cells even at concentration up to 250 μM. Of note, 2,2′‐dithiobis(N‐(2‐fluorophenyl)acetamide) (d7), 2,2′‐dithiobis(N‐(3,5‐difluorophenyl)acetamide) (d24), and 2,2′‐dithiobis(N‐(3‐fluorophenyl)acetamide) (d8) were here identified as the most active inhibitors with IC50 of 0.074, 0.44, and 0.81 μM, showing 32‐ to 355‐fold higher potency than the positive control acetohydroxamic acid. These disulfides were confirmed to bind urease without covalent modification of the cysteine residue and to inhibit urease reversibly with a mixed inhibition mechanism. They also showed very good anti‐Helicobacter pylori activities with d8 showing a comparable potency to the clinical used drug amoxicillin. The impressive in vitro biological profile indicated their immense potential as therapeutic agents to tackle H. pylori caused infections.