bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic Review and Meta–Analysis of the Association Between Non–Steroidal Anti–Inflammatory Drugs and Operative Bleeding in the Perioperative Period
Authors: Bongiovanni Tasce , Lancaster Elizabeth , Ledesma Yeranuí , Whitaker Evans , Steinman Michael A. , Allen Isabel Elaine , Auerbach Andrew , Wick Elizabeth 
Published: January 2021

BACKGROUND:
It is increasingly recognized that non-opioid analgesia is an important analgesia in the perioperative period. Specifically, NSAIDs (nonsteroidal anti-inflammatory drugs) have been touted as an adjunct, or even replacement, for opioids. However, uptake of NSAIDs has been slow due to concern for side effects, including bleeding. We sought to understand the risk of bleeding caused by NSAIDs in the perioperative period.

STUDY DESIGN:
A physician–librarian team performed a search of electronic databases (MEDLINE, EMBASE), using search terms covering the targeted intervention (use of NSAIDs) and outcomes of interest (surgical complications, bleeding), limited to English language articles of any date. We performed a systematic review and meta-analysis of the data.

RESULTS:
A total of 2,521 articles were screened, and 229 were selected on the basis of title and abstract for detailed assessment. Including reference searching, 74 manuscripts met inclusion criteria spanning years 1987–2019. These studies included 151,031 patients. Studies included 12 types of NSAIDs, the most common being ketorolac, diclofenac, and ibuprofen, over a wide–range of procedures, from otorhinolaryngology (ENT), breast, abdomen, plastics, and more. More than half were randomized control trials. The meta-analyses for hematoma, return to the operating room for bleeding, and blood transfusions showed no difference in risk in any of 3 categories studied between the NSAID vs non-NSAID groups (p = 0.49, p = 0.79, and p = 0.49, respectively). Quality scoring found a wide range of quality, with scores ranging from lowest quality of 12 to highest quality of 25, out of a total of 27 (average = 16).

CONCLUSIONS:
NSAIDs are unlikely to be the cause of postoperative bleeding complications. This literature covers a large number of patients and remains consistent across types of NSAIDs and operations.
The state of the art and operational scenarios for urban air mobility with unmanned aircraft
Authors: Maia F. D. , Lourenço da Saúde J. M. 
Published: January 2021

ABSTRACTA state-of-the-art review of all the developments, standards and regulations associated with the use of major unmanned aircraft systems under development is presented. Requirements and constraints are identified by evaluating technologies specific to urban air mobility, considering equivalent levels of safety required by current and future civil aviation standards. Strategies, technologies and lessons learnt from remotely piloted aviation and novel unmanned traffic management systems are taken as the starting point to assess operational scenarios for autonomous urban air mobility.
EVIDENCE FOR SLINGSTONES AND RELATED PROJECTILE STONE USE BY THE ANCIENT MAYA OF THE USUMACINTA RIVER VALLEY REGION
Authors: Recinos Alejandra Roche , Firpi Omar Alcover , Rodas Ricardo 
Published: January 2021

AbstractIn this study, we present evidence for the use of slingstones and other projectile stones among the ancient Maya peoples of the Usumacinta River region. Rounded stones are frequently found across Maya archaeological sites and are given a range of interpretations, including objects for flintknapping, cooking, ritual, divination, and less often as weapons. Here we provide new evidence for the identification of rounded stones as weapons based on their morphology as well as their context of recovery. We employ data from the sites of Macabilero, Guatemala, and Budsilha, Mexico, which strongly suggest rounded stones at these sites were manufactured to be used as weapons. These findings have implications for how we understand warfare and hunting in ancient Mesoamerica and inform our interpretation of how the Maya prepared for such activities. As a class of weapon potentially accessible to most members of Maya society, the results presented here show the importance of more inclusive perspectives on Maya warfare and the necessity of contextualizing artifact analysis within the occupation history of the broader site and region.
Safe On-Boat Resuscitation by Lifeguards in COVID-19 Era: A Pilot Study Comparing Three Sets of Personal Protective Equipment
Authors: Barcala-Furelos Roberto , Abelairas-Gómez Cristian , Alonso-Calvete Alejandra , Cano-Noguera Francisco , Carballo-Fazanes Aida , Martínez-Isasi Santiago , Rodríguez-Núñez Antonio 
Published: January 2021

AbstractIntroduction:On-boat resuscitation can be applied by lifeguards in an inflatable rescue boat (IRB). Due to Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-COV-2) and recommendations for the use of personal protective equipment (PPE), prehospital care procedures need to be re-evaluated. The objective of this study was to determine how the use of PPE influences the amount of preparation time needed before beginning actual resuscitation and the quality of cardiopulmonary resuscitation (CPR; QCPR) on an IRB.Methods:Three CPR tests were performed by 14 lifeguards, in teams of two, wearing different PPE: (1) Basic PPE (B-PPE): gloves, a mask, and protective glasses; (2) Full PPE (F-PPE): B-PPE + a waterproof apron; and (3) Basic PPE + plastic blanket (B+PPE). On-boat resuscitation using a bag-valve-mask (BVM) and high efficiency particulate air (HEPA) filter was performed sailing at 20km/hour.Results:Using B-PPE takes less time and is significantly faster than F-PPE (B-PPE 17 [SD = 2] seconds versus F-PPE 69 [SD = 17] seconds; P = .001), and the use of B+PPE is slightly higher (B-PPE 17 [SD = 2] seconds versus B+PPE 34 [SD = 6] seconds; P = .002). The QCPR remained similar in all three scenarios (P >.05), reaching values over 79%.Conclusion:The use of PPE during on-board resuscitation is feasible and does not interfere with quality when performed by trained lifeguards. The use of a plastic blanket could be a quick and easy alternative to offer extra protection to lifeguards during CPR on an IRB.
Global Venus‐Solar Wind Coupling and Oxygen Ion Escape
Authors: Persson M. , Futaana Y. , Ramstad R. , Schillings A. , Masunaga K. , Nilsson H. , Fedorov A. , Barabash S. 
Published: January 2021

AbstractThe present‐day Venusian atmosphere is dry, yet, in its earlier history a significant amount of water evidently existed. One important water loss process comes from the energy and momentum transfer from the solar wind to the atmospheric particles. Here, we used measurements from the Ion Mass Analyzer onboard Venus Express to derive a relation between the power in the upstream solar wind and the power leaving the atmosphere through oxygen ion escape in the Venusian magnetotail. We find that on average 0.01% of the available power is transferred, and that the percentage decreases as the available energy increases. For Mars the trend is similar, but the efficiency is higher. At Earth, the ion escape does not behave similarly, as the ion escape only increases after a threshold in the available energy is reached. These results indicate that the Venusian induced magnetosphere efficiently screens the atmosphere from the solar wind.
On the Nature of F‐Region Bottom‐Type Echoing Layer Over Gadanki
Authors: Pavan Chaitanya P. , Patra A. K. 
Published: January 2021

AbstractBottom‐type echoing layers observed from Gadanki are presented and analyzed. The analysis is based on observations made using a substantial database of the 30 MHz Gadanki Ionospheric Radar Interferometer (GIRI) during 2017–2019, collocated digisonde observations, and a few days of overlapping volume observations made using the GIRI and the 53 MHz Advanced Indian MST Radar (AIR) . The echoes commence well before the E‐ and F‐region sunsets and last as late as 23:00 Local Time. The echoing layers occur in the height range of 220–300 km with a thickness of 10–15 km and the Doppler spectra are narrow with spectral width confined to 10 m s−1. The echoing layers are very common during the entire observational period and do not show any noticeable seasonal dependence. The zonal velocities of the irregularities responsible for the radar echoes are close to zero irrespective of the height of the echoing region. The echoes are stronger at 30 MHz than at 53 MHz indicating strong Bragg scale dependence. The height of the echoing layer agrees very well with the height of the F‐region peak electron density (hmF2). Also, early commencement of the echoing layer is found to be associated with low hmF2 and corresponding high electron density (foF2). While the results indicate toward the wind‐driven interchange instability as their origin, the early onset of the echoing layer and its relationship with the background ionospheric parameters call for explanation. The results are discussed in the light of current understanding on the bottom‐type echoing layer.
Impact of the Ionosphere Disturbed by Rocket Plume on OTHR Radio Wave Propagation
Authors: Ma Xin , Fang Hanxian , Wang Sicheng , Chang Shujie 
Published: January 2021

AbstractThe main chemicals of rocket exhaust plume are released into the ionosphere, which cause three‐dimensional (3‐D) disturbances. By simulating the disturbance, we investigate the influence of ionospheric disturbance by the chemical release on the propagation of over‐the‐horizon radar (OTHR) waves. Based on the absorption simulation model, the absorption loss of OTHR waves caused by rocket plume was simulated. Using 3‐D digital ray tracing, we simulated the propagation path of radio waves in the “ionospheric hole” region. The simulation results show that the absorption loss of short waves decreases with an increase in the frequency and elevation angle of the ray. The absorption loss in the year of high solar activity is significantly higher than that in the year of low solar activity. The absorption value is largest at noon and smallest at night. In terms of seasonal variation, the absorption of radio waves is strongest in summer and weakest in winter. Additionally, the ionospheric hole area increases with the release time. The 6 MHz high‐frequency waves cannot reach the disturbance height and are completely reflected to the ground. Most of the 8 MHz radio waves are reflected to the ground, and some of them pass through the ionosphere. The radio waves at 10, 15, and 20 MHz can pass through the hole area of the ionosphere. Moreover, the ionospheric disturbance generated by the plume has a focusing effect on the propagation of OTHR shortwaves. With the increase in radio frequency, the focusing height gradually increases, and the focusing effect gradually weakens.
Bayesian Integration Using Resistivity and Lithology for Improving Estimation of Hydraulic Conductivity
Authors: Cheng Shih‐Yang , Hsu Kuo‐Chin 
Published: January 2021

AbstractThe characterization of spatially heterogeneous hydraulic conductivity (K) is important in groundwater resources management. We propose a Bayesian statistical method that integrates multiple secondary data (continuous and category data) with primary data (K) to improve regional K field characterization. Considering the disparity of the data scale, spatial scarcity of primary and secondary data, and need for regional‐scale site characterization, the aquifer thickness is used as the scale for data integration. We transform the high‐resolution secondary data to the scale of K and perform linear/nonlinear regression analyses for the transformed secondary data and primary data. A Bayesian approach using Metropolis‐within‐Gibbs sampling is developed for jointly integrating the primary and transformed secondary data without a limitation on the type of data attribute and the number of data set. A synthetic example is first presented to demonstrate the capability of the proposed method. Results show that the correlation strength, not the relation type, is the primary factor for improving the estimates. The Bayesian method is applied to Choushui River alluvial fan in Taiwan. Resistivity logs and a lithological description are first upscaled and then simultaneously integrated in the K estimation. Results indicate that the improvement of the K estimate obtained using resistivity data is higher in the proximal and mid fans but lower in the distal fan compared to that obtained using lithofacies data. Jointly integrating two‐attribute data outperforms using one or no secondary data set for K estimates. The proposed Bayesian integration method is thus versatile and suitable for large‐scale aquifer characterization.
Probing the subcellular nanostructure of engineered human cardiomyocytes in 3D tissue
Authors: Javor Josh , Ewoldt Jourdan K. , Cloonan Paige E. , Chopra Anant , Luu Rebeccah J. , Freychet Guillaume , Zhernenkov Mikhail , Ludwig Karl , Seidman Jonathan G. , Seidman Christine E. , Chen Christopher S. , Bishop David J. 
Published: January 2021

AbstractThe structural and functional maturation of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) is essential for pharmaceutical testing, disease modeling, and ultimately therapeutic use. Multicellular 3D-tissue platforms have improved the functional maturation of hiPSC-CMs, but probing cardiac contractile properties in a 3D environment remains challenging, especially at depth and in live tissues. Using small-angle X-ray scattering (SAXS) imaging, we show that hiPSC-CMs matured and examined in a 3D environment exhibit a periodic spatial arrangement of the myofilament lattice, which has not been previously detected in hiPSC-CMs. The contractile force is found to correlate with both the scattering intensity (R2 = 0.44) and lattice spacing (R2 = 0.46). The scattering intensity also correlates with lattice spacing (R2 = 0.81), suggestive of lower noise in our structural measurement than in the functional measurement. Notably, we observed decreased myofilament ordering in tissues with a myofilament mutation known to lead to hypertrophic cardiomyopathy (HCM). Our results highlight the progress of human cardiac tissue engineering and enable unprecedented study of structural maturation in hiPSC-CMs.
Similarities and dissimilarities between psychiatric cluster disorders
Authors: Smail Marissa A. , Wu Xiaojun , Henkel Nicholas D. , Eby Hunter M. , Herman James P. , McCullumsmith Robert E. , Shukla Rammohan 
Published: January 2021

AbstractThe common molecular mechanisms underlying psychiatric disorders are not well understood. Prior attempts to assess the pathological mechanisms responsible for psychiatric disorders have been limited by biased selection of comparable disorders, datasets/cohort availability, and challenges with data normalization. Here, using DisGeNET, a gene-disease associations database, we sought to expand such investigations in terms of number and types of diseases. In a top-down manner, we analyzed an unbiased cluster of 36 psychiatric disorders and comorbid conditions at biological pathway, cell-type, drug-target, and chromosome levels and deployed density index, a novel metric to quantify similarities (close to 1) and dissimilarities (close to 0) between these disorders at each level. At pathway level, we show that cognition and neurotransmission drive the similarity and are involved across all disorders, whereas immune-system and signal-response coupling (cell surface receptors, signal transduction, gene expression, and metabolic process) drives the dissimilarity and are involved with specific disorders. The analysis at the drug-target level supports the involvement of neurotransmission-related changes across these disorders. At cell-type level, dendrite-targeting interneurons, across all layers, are most involved. Finally, by matching the clustering pattern at each level of analysis, we showed that the similarity between the disorders is influenced most at the chromosomal level and to some extent at the cellular level. Together, these findings provide first insights into distinct cellular and molecular pathologies, druggable mechanisms associated with several psychiatric disorders and comorbid conditions and demonstrate that similarities between these disorders originate at the chromosome level and disperse in a bottom-up manner at cellular and pathway levels.
Regulation of cardiomyocyte fate plasticity: a key strategy for cardiac regeneration
Authors: Gong Rui , Jiang Zuke , Zagidullin Naufal , Liu Tianyi , Cai Benzhi 
Published: January 2021

AbstractWith the high morbidity and mortality rates, cardiovascular diseases have become one of the most concerning diseases worldwide. The heart of adult mammals can hardly regenerate naturally after injury because adult cardiomyocytes have already exited the cell cycle, which subseqently triggers cardiac remodeling and heart failure. Although a series of pharmacological treatments and surgical methods have been utilized to improve heart functions, they cannot replenish the massive loss of beating cardiomyocytes after injury. Here, we summarize the latest research progress in cardiac regeneration and heart repair through altering cardiomyocyte fate plasticity, which is emerging as an effective strategy to compensate for the loss of functional cardiomyocytes and improve the impaired heart functions. First, residual cardiomyocytes in damaged hearts re-enter the cell cycle to acquire the proliferative capacity by the modifications of cell cycle-related genes or regulation of growth-related signals. Additionally, non-cardiomyocytes such as cardiac fibroblasts, were shown to be reprogrammed into cardiomyocytes and thus favor the repair of damaged hearts. Moreover, pluripotent stem cells have been shown to transform into cardiomyocytes to promote heart healing after myocardial infarction (MI). Furthermore, in vitro and in vivo studies demonstrated that environmental oxygen, energy metabolism, extracellular factors, nerves, non-coding RNAs, etc. play the key regulatory functions in cardiac regeneration. These findings provide the theoretical basis of targeting cellular fate plasticity to induce cardiomyocyte proliferation or formation, and also provide the clues for stimulating heart repair after injury.
Mercury methylation by metabolically versatile and cosmopolitan marine bacteria
Authors: Lin Heyu , Ascher David B , Myung Yoochan , Lamborg Carl H , Hallam Steven J , Gionfriddo Caitlin M , Holt Kathryn E , Moreau John W 
Published: January 2021

Abstract
Microbes transform aqueous mercury (Hg) into methylmercury (MeHg), a potent neurotoxin that accumulates in terrestrial and marine food webs, with potential impacts on human health. This process requires the gene pair hgcAB, which encodes for proteins that actuate Hg methylation, and has been well described for anoxic environments. However, recent studies report potential MeHg formation in suboxic seawater, although the microorganisms involved remain poorly understood. In this study, we conducted large-scale multi-omic analyses to search for putative microbial Hg methylators along defined redox gradients in Saanich Inlet, British Columbia, a model natural ecosystem with previously measured Hg and MeHg concentration profiles. Analysis of gene expression profiles along the redoxcline identified several putative Hg methylating microbial groups, including Calditrichaeota, SAR324 and Marinimicrobia, with the last the most active based on hgc transcription levels. Marinimicrobia hgc genes were identified from multiple publicly available marine metagenomes, consistent with a potential key role in marine Hg methylation. Computational homology modelling predicts that Marinimicrobia HgcAB proteins contain the highly conserved amino acid sites and folding structures required for functional Hg methylation. Furthermore, a number of terminal oxidases from aerobic respiratory chains were associated with several putative novel Hg methylators. Our findings thus reveal potential novel marine Hg-methylating microorganisms with a greater oxygen tolerance and broader habitat range than previously recognized.
Feasibility of photon-counting spectral CT in dental applications—a comparative qualitative analysis
Authors: Vanden Broeke L. , Grillon M. , Yeung A. W. K. , Wu W. , Tanaka R. , Vardhanabhuti V. 
Published: January 2021

Abstract
Purpose
The goal of this study was to demonstrate the feasibility of using photon-counting spectral CT for dental applications. This paper qualitatively analyzes the visibility of accessory canals (ACs) and metal artefacts from dental implants for cone-beam CT (CBCT), microtomography (microCT), and photon-counting spectral CT (PCSCT).

Materials and methods
All of the teeth in this study were extracted, and eight teeth in total were scanned on a CBCT scanner, a microCT scanner and on a PCSCT scanner. Six of the teeth that were scanned have accessory canals, one has a titanium rod attached to it, and one has a gutta-percha point inside it. Qualitative analysis was done to compare the different imaging modalities.

Results
The subjective image analysis demonstrated similar performance in AC detection and visualisation for PCSCT and CBCT (p value >0.05). Both PCSCT and microCT performed similarly for metal artefact reduction, and both were superior to CBCT (p value <0.05).

Conclusion
Although microCT provides detailed information about small anatomical structures, it is not suitable for in vivo use. However, the PCSCT scanner was able to detect small anatomical structures in teeth comparable to CBCT, as well as being superior in reducing metal artefacts from dental implants. This study showed that PCSCT is a promising modality for future dentistry applications.
The DNA-helicase HELLS drives ALK− ALCL proliferation by the transcriptional control of a cytokinesis-related program
Authors: Tameni Annalisa , Sauta Elisabetta , Mularoni Valentina , Torricelli Federica , Manzotti Gloria , Inghirami Giorgio , Bellazzi Riccardo , Fragliasso Valentina , Ciarrocchi Alessia 
Published: January 2021

AbstractDeregulation of chromatin modifiers, including DNA helicases, is emerging as one of the mechanisms underlying the transformation of anaplastic lymphoma kinase negative (ALK−) anaplastic large cell lymphoma (ALCL). We recently identified the DNA-helicase HELLS as central for proficient ALK−ALCL proliferation and progression. Here we assessed in detail its function by performing RNA-sequencing profiling coupled with bioinformatic prediction to identify HELLS targets and transcriptional cooperators. We demonstrated that HELLS, together with the transcription factor YY1, contributes to an appropriate cytokinesis via the transcriptional regulation of genes involved in cleavage furrow regulation. Binding target promoters, HELLS primes YY1 recruitment and transcriptional activation of cytoskeleton genes including the small GTPases RhoA and RhoU and their effector kinase Pak2. Single or multiple knockdowns of these genes reveal that RhoA and RhoU mediate HELLS effects on cell proliferation and cell division of ALK−ALCLs. Collectively, our work demonstrates the transcriptional role of HELLS in orchestrating a complex transcriptional program sustaining neoplastic features of ALK−ALCL.