bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amitriptyline functionally antagonizes cardiac H2 histamine receptors in transgenic mice and human atria
Authors: Neumann Joachim , Binter Maximilian Benedikt , Fehse Charlotte , Marušáková Margaréta , Büxel Maren Luise , Kirchhefer Uwe , Hofmann Britt , Gergs Ulrich 
Published: February 2021

AbstractWe have previously shown that histamine (2-(1H-imidazol-4-yl)ethanamine) exerted concentration-dependent positive inotropic effects (PIE) or positive chronotropic effects (PCE) on isolated left and right atria, respectively, of transgenic (H2R-TG) mice that overexpress the human H2 histamine receptor (H2R) in the heart; however, the effects were not seen in their wild-type (WT) littermates. Amitriptyline, which is still a highly prescribed antidepressant drug, was reported to act as antagonist on H2Rs. Here, we wanted to determine whether the histamine effects in H2R-TG were antagonized by amitriptyline. Contractile studies were performed on isolated left and right atrial preparations, isolated perfused hearts from H2R-TG and WT mice and human atrial preparations. Amitriptyline shifted the concentration-dependent PIE of histamine (1 nM–10 μM) to higher concentrations (rightward shift) in left atrial preparations from H2R-TG. Similarly, in isolated perfused hearts from H2R-TG and WT mice, histamine increased the contractile parameters and the phosphorylation state of phospholamban (PLB) at serine 16 in the H2R-TG mice, but not in the WT mice. However, the increases in contractility and PLB phosphorylation were attenuated by the addition of amitriptyline in perfused hearts from H2R-TG. In isolated electrically stimulated human atria, the PIE of histamine that was applied in increasing concentrations from 1 nM to 10 μM was reduced by 10-μM amitriptyline. In summary, we present functional evidence that amitriptyline also acts as an antagonist of contractility at H2Rs in H2R-TG mouse hearts and in the human heart which might in part explain the side effects of amitriptyline.
Ultrasound-Guided Minimal Invasive Carpal Tunnel Release: An Optimized Algorithm
Authors: Loizides Alexander , Honold Sarah , Skalla-Oberherber Elisabeth , Gruber Leonhard , Löscher Wolfgang , Moriggl Bernhard , Konschake Marko , Gruber Hannes 
Published: February 2021

Abstract
Purpose
To present a safety-optimized ultrasound-guided minimal invasive carpal tunnel release (CTR) procedure.

Materials and Methods
104 patients (67 female, 37 male; mean age 60.6 ± 14.3 years, 95% CI 57.9 to 63.4 years) with clinical and electrophysiological verified typical carpal tunnel syndrome were referred for a high-resolution ultrasound of the median nerve and were then consecutively assigned for an ultrasound-guided CTR after exclusion of possible secondary causes of carpal tunnel syndrome such as tumors, tendovaginitis, ganglia and possible contraindications (e.g., crossing collateral vessels, nerve variations). Applying a newly adapted and optimized algorithm, basing on the work proposed by Petrover et al. CTR was performed using a button tip cannula which has several safety advantages: On the one hand, the button tip cannula acts as a blunt and atraumatic guiding splint for the subsequent insertion of the hook-knife, and on the other hands, it serves as a “hydro-inflation”-tool, i.e., a fluid-based expansion of the working-space is warranted during the whole procedure whenever needed.

Results
In all patients, successful releases were confirmed by the depiction of a completely transected transverse carpal ligament during and in the postoperative ultrasound-controls two weeks after intervention. All patients reported markedly reduction of symptoms promptly after this safety-optimized ultrasound-guided minimal invasive CTR and at the follow-up examination. No complications were evident.

Conclusion
The here proposed optimized algorithm assures a reliable and safe ultrasound-guided CTR and thus should be taken into account for this minimal invasive interventional procedure.
Histamine, mast cell tryptase and post-exercise hypotension in healthy and collapsed marathon runners
Authors: Parsons I. T. , Stacey M. J. , Faconti L. , Hill N. , O’Hara J. , Walter E. , Farukh B. , McNally R. , Sharp H. , Patten A. , Grimaldi R. , Gall N. , Chowienczyk P. , Woods D. R. 
Published: February 2021

Abstract
Purpose
Heat stress exacerbates post-exercise hypotension (PEH) and cardiovascular disturbances from elevated body temperature may contribute to exertion-related incapacity. Mast cell degranulation and muscle mass are possible modifiers, though these hypotheses lack practical evidence. This study had three aims: (1) to characterise pre–post-responses in histamine and mast cell tryptase (MCT), (2) to investigate relationships between whole body muscle mass (WBMM) and changes in blood pressure post-marathon, (3) to identify any differences in incapacitated runners.

Methods
24 recreational runners were recruited and successfully completed the 2019 Brighton Marathon (COMPLETION). WBMM was measured at baseline. A further eight participants were recruited from incapacitated runners (COLLAPSE). Histamine, MCT, blood pressure, heart rate, body temperature and echocardiographic measures were taken before and after exercise (COMPLETION) and upon incapacitation (COLLAPSE).

Results
In completion, MCT increased by nearly 50% from baseline (p = 0.0049), whereas histamine and body temperature did not vary (p > 0.946). Systolic (SBP), diastolic (DBP) and mean (MAP) arterial blood pressures and systemic vascular resistance (SVR) declined (p < 0.019). WBMM negatively correlated with $$\Delta $$
Δ
SBP (r = − 0.43, p = 0.046). For collapse versus completion, there were significant elevations in MCT (1.77 ± 0.25 μg/L vs 1.18 ± 0.43 μg/L, p = 0.001) and body temperature (39.8 ± 1.3 °C vs 36.2 ± 0.8 °C, p < 0.0001) with a non-significant rise in histamine (9.6 ± 17.9 μg/L vs 13.7 ± 33.9 μg/L, p = 0.107) and significantly lower MAP, DBP and SVR (p < 0.033).

Conclusion
These data support the hypothesis that mast cell degranulation is a vasodilatory mechanism underlying PEH and exercise associated collapse. The magnitude of PEH is inversely proportional to the muscle mass and enhanced by concomitant body heating.
Perinatal risk factors for pediatric onset type 1 diabetes, autoimmune thyroiditis, juvenile idiopathic arthritis, and inflammatory bowel diseases
Authors: Räisänen Laura , Viljakainen Heli , Sarkkola Catharina , Kolho Kaija-Leena 
Published: February 2021

AbstractType 1 diabetes mellitus (DM), autoimmune thyroiditis (AIT), juvenile idiopathic arthritis (JIA), and inflammatory bowel diseases (IBD) are common pediatric autoimmune diseases with unknown risk factors. Using nationwide registers, we searched for their perinatal risk factors. Our study followed up 11,407 children (born 2000–2005) for a median of 16.6 years (from birth to 2018). Of them, 2.15% received primary diagnosis and 0.08% also secondary: 0.89% had DM, 0.60% had AIT, 0.48% had JIA, and 0.25% had IBD. The incidences per 100,000 children/year were 106.1 for DM, 46.0 for AIT, 55.0 for JIA, and 23.7 for IBD. There were more preterm births (< 37 weeks) among children with studied autoimmune diseases compared with the rest of the cohort (8.6% vs. 5.3%, p = 0.035). Among those born preterm, children with studied autoimmune diseases received more postnatal antibiotics compared with other preterm children in the cohort (47.6% vs. 27.7%, p = 0.046). Children with IBD were born to older mothers compared with those without studied diagnoses (33.0 vs 30.2, p = 0.004).Conclusion: Preterm birth was a shared risk factor for autoimmune diseases in our study, especially when combined with postnatal antibiotic treatments. High maternal age was associated with IBD.

What is Known:• Type 1 diabetes (DM), autoimmune thyroiditis (AIT), juvenile idiopathic arthritis (JIA), and inflammatory bowel diseases (IBD) are common pediatric autoimmune diseases• It is unclear whether these diseases have shared risk factors, since there are no previous simultaneous epidemiological nor follow-up studies on them in one cohort

What is New:• Preterm births were more common in children with DM, AIT, JIA, or IBD compared with other children in the cohort, and preterm children who developed these diseases recieved more postnatal antibiotics compared with other preterm children• High maternal age was associated with IBD
Ökodesign von Stahlwerksschlacken durch thermochemische Behandlung zur Erhöhung der Recyclingfähigkeit
Authors: Vollprecht Daniel , Pomberger Roland 
Published: February 2021

ZusammenfassungÖkodesign ist ein Konzept zur Gestaltung von Produkten, dessen Ziel es ist, die Umweltbelastung zu verringern. Theoretische, praktische und reale Recyclingfähigkeit sind Eigenschaften eines Produktes, am Ende seines Lebenszyklus stofflich verwertet werden zu können, wobei „Recycling“ stets impliziert, dass das Produkt zeitweilig zu Abfall wird.Stahlwerksschlacken werden im pyrometallurgischen Prozess gezielt durch die Zugabe von Schlackenbildnern erzeugt und erfüllen dort eine Funktion, indem sie die im Stahl unerwünschten Begleitelemente der eingesetzten geogenen oder anthropogenen Erze aufnehmen. Stahlwerksschlacken sind somit jedenfalls im Hinblick auf die metallurgische Nutzungsphase Produkt, können aber an deren Ende – je nach Judikatur – Abfall werden oder Nebenprodukt sein. In beiden Fällen handelt es sich um Reststoffe, die als industriell hergestellte Gesteinskörnungen Sekundärrohstoffe für den Straßenbau darstellen.Die thermochemische Behandlung von Stahlwerksschlacken im flüssigen Zustand kann die Freisetzung umweltrelevanter Elemente in Poren- und Grundwässer und damit die Umweltbelastung verringern, indem diese Elemente in stabilen Mineralphasen eingebaut und/oder nach einer anfänglichen Freisetzung wieder an deren Oberflächen adsorbiert werden können.Diese gezielte Steuerung der Produktionsbedingungen von Stahlwerksschlacken stellt somit ein Beispiel für Ökodesign dar und ist zudem für jene Fälle, in denen die Schlacke zu Abfall wird, ein wesentlicher Beitrag zur Erhöhung der theoretischen Recyclingfähigkeit der Schlacke, die in diesem Spezialfall mit der praktischen und realen Recyclingfähigkeit zusammenfällt.
Vinorelbine as substitute for vincristine in patients with diffuse large B cell lymphoma and vincristine-induced neuropathy
Authors: Hatzl Stefan , Posch Florian , Rezai Arwin , Gornicec Maximilian , Beham-Schmid Christine , Magnes Theresa , Wangner Sandro , Deutsch Alexander , Greinix Hildegard , Uhl Barbara , Prochazka Katharina T. , Egle Alexander , Greil Richard , Melchardt Thomas , Linkesch Werner , Schulz Eduard , Neumeister Peter 
Published: February 2021

Abstract
Background
A combination of rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is the standard first-line therapy for diffuse large B cell lymphoma (DLBCL), the most common aggressive lymphoma in adults. One of the major adverse effects of this regimen is vincristine-induced polyneuropathy which leads to discontinuation of vincristine in up to 30% of DLBCL-patients. Dose reduction of vincristine might worsen treatment outcomes of DLBCL but identification of treatment alternatives for patients exhibiting peripheral neuropathy during R-CHOP is an unmet need in hematology.

Methods
In this retrospective cohort study, comprising 987 patients with de novo DLBCL, we delineated the role of vinorelbine as a substitute for vincristine in R-CHOP by measuring improvements in neuropathy and outcome variables.

Results
Five-year overall survival (OS) and progression-free survival (PFS) were 72.6% and 63.1% in patients who received regular doses of vincristine, as compared to 60.6% and 51.7% in patients who received reduced doses of vincristine (p = 0.022 and p = 0.003, respectively). Of 199 patients who switched to vinorelbine, the majority experienced an improvement of neuropathy Furthermore, vinorelbine-switched patients showed favorable oncologic outcomes.

Conclusion
Replacement of vincristine by vinorelbine due to neuropathy is effective and safe, and results in a significant improvement in neuropathy as compared to treatment with R-CHOP.
Modellierung der küstennahen Grundwasserversalzung in Niedersachsen abgeleitet aus aeroelektromagnetischen Daten
Authors: González Eva , Deus Nico , Elbracht Jörg , Siemon Bernhard , Steuer Annika , Wiederhold Helga 
Published: February 2021

ZusammenfassungDie Bundesanstalt für Geowissenschaften und Rohstoffe (BGR) führte in den Jahren 2000–2014 umfangreiche (etwa 5900 km2) aerogeophysikalische Erkundungen an der niedersächsischen Nordseeküste durch. Die Aeroelektromagnetik liefert Informationen über die elektrisch leitfähigen Strukturen im Erduntergrund und ermöglicht die Unterscheidung von Süß- und Salzwasser wie auch von Tonen und Sanden. Im Landesamt für Bergbau, Energie und Geologie (LBEG) sowie am Leibniz Institut für Angewandte Geophysik (LIAG) wurden diese Daten zur Kartierung der Tiefenlage der Süß‑/Salzwassergrenze genutzt. Dadurch ist unter anderem eine detaillierte Karte der Grundwasserversalzung innerhalb der küstennahen Aquifere entlang der niedersächsischen Nordseeküste im Maßstab 1:50.000 entstanden. Diese zeigt den aktuellen Stand der Grundwasserversalzung, abgeleitet aus den gewonnenen Elektromagnetik-Modellen. Die Modelle waren auch Grundlage für eine hydraulische Modellierung der Süßwasserlinse der Nordseeinsel Borkum. Darauf aufbauende Simulationen zeigen die Entwicklung der Grundwassersituation für den Zeitraum bis 2100.
Adjusted productivity costs of stroke by human capital and friction cost methods: a Northern Finland Birth Cohort 1966 study
Authors: Rissanen Ina , Ala-Mursula Leena , Nerg Iiro , Korhonen Marko 
Published: February 2021

Abstract
Background
Productivity costs result from loss of paid and unpaid work and replacements due to morbidity and mortality. They are usually assessed in health economic evaluations with human capital method (HCM) or friction cost method (FCM). The methodology for estimating lost productivity is an area of considerable debate.

Objective
To compare traditional and adjusted HCM and FCM productivity cost estimates among young stroke patients.

Methods
The Northern Finland Birth Cohort 1966 was followed until the age of 50 to identify all 339 stroke patients whose productivity costs were estimated with traditional, occupation-specific and adjusted HCM and FCM models by using detailed, national register-based data on care, disability, mortality, education, taxation and labour market.

Results
Compared to traditional HCM, taking into account occupational class, national unemployment rate, disability-free life expectancy and decline in work ability, the productivity cost estimate decreased by a third, from €255,960 to €166,050. When traditional FCM was adjusted for occupational class and national unemployment rate, the estimate more than doubled from €3,040 to €7,020. HCM was more sensitive to adjustments for discount rate and wage growth rate than FCM.

Conclusions
This study highlights the importance of adjustments of HCM and FCM. Routine register-based data can be used for accurate productivity cost estimates of health shocks.
Innovative passive reinforcements for the gradual stabilization of a landslide according with the observational method
Authors: Brezzi Lorenzo , Bisson Alberto , Pasa Davide , Cola Simonetta 
Published: February 2021

AbstractA large number of landslides occur in North-Eastern Italy during every rainy period due to the particular hydrogeological conditions of this area. Even if there are no casualties, the economic losses are often significant, and municipalities frequently do not have sufficient financial resources to repair the damage and stabilize all the unstable slopes. In this regard, the research for more economically sustainable solutions is a crucial challenge. Floating composite anchors are an innovative and low-cost technique set up for slope stabilization: it consists in the use of passive sub-horizontal reinforcements, obtained by coupling a traditional self-drilling bar with some tendons cemented inside it. This work concerns the application of this technique according to the observational method described within the Italian and European technical codes and mainly recommended for the design of geotechnical works, especially when performed in highly uncertain site conditions. The observational method prescribes designing an intervention and, at the same time, using a monitoring system in order to correct and adapt the project during realization of the works on the basis of new data acquired while on site. The case study is the landslide of Cischele, a medium landslide which occurred in 2010 after an exceptional heavy rainy period. In 2015, some floating composite anchors were installed to slow down the movement, even if, due to a limited budget, they were not enough to ensure the complete stabilization of the slope. Thanks to a monitoring system installed in the meantime, it is now possible to have a comparison between the site conditions before and after the intervention. This allows the evaluation of benefits achieved with the reinforcements and, at the same time, the assessment of additional improvements. Two stabilization scenarios are studied through an FE model: the first includes the stabilization system built in 2015, while the second evaluates a new solution proposed to further increase the slope stability.
Polish students’ knowledge of dietary supplements
Authors: Brodziak-Dopierała Barbara , Fischer Agnieszka , Ahnert Bożena 
Published: February 2021

Abstract
Background
The increasing intake of dietary supplements (DS) can be observed worldwide. These preparations are classified as a special category of foods and are subject to food law, not pharmaceutical regulations. As a result, the requirements for DS are much less restrictive than for medications.

Methodology
This research was conducted in a group of young Polish students of pharmacy at the Medical University of Silesia in Katowice (SUM) and of finance and accounting at the University of Economics in Katowice (UE). The survey contained questions concerning DS, such as difference to drugs, scope of use, and safety.

Results
The respondents answered questions about taking DS and the effects of their use. DS were used either currently or in the past by about 70% of the respondents, while about 30% of the surveyed population declared that they did not use these preparations. Women and UE students predominated among those not taking DS.

Conclusion
Multi-component products taken for a period of less than 3 months to supplement a deficit for a given component were used the most often. One product was taken at a time. The respondents read product information and followed the recommended doses. Over 50% of the studied population was aware of the negative effects of DS. Adverse symptoms of DS use were observed by 5% of the respondents.
Associations Between Key Psychosocial Stressors and Viral Suppression and Retention in Care Among Youth with HIV in Rural South Africa
Authors: Filiatreau Lindsey M. , Pettifor Audrey , Edwards Jessie K. , Masilela Nkosinathi , Twine Rhian , Xavier Gómez-Olivé F. , Haberland Nicole , Kabudula Chodziwadziwa Whiteson , Lippman Sheri A. , Kahn Kathleen 
Published: February 2021

AbstractDespite improvements in access to antiretroviral treatment over the past decade, sub-optimal HIV care outcomes persist among youth with HIV (YWH) in rural South Africa. Psychosocial stressors could impede improved HIV treatment outcomes within this population. We linked self-reported psychosocial health and demographic data from a cross-sectional survey conducted among YWH aged 12–24 in rural South Africa to individual medical record data, including facility visit history and viral load measurements. Poisson regression with robust standard errors was used to estimate the associations between five psychosocial stressors- heightened depressive symptoms (Center for Epidemiological Studies-Depression scale scores ≥ 16), lower social support (Medical Outcomes Social Support Scale scores ≤ 38), lower resilience (Conner-Davidson Resilience Scale scores ≤ 73), lower self-esteem (Rosenberg Self-Esteem Scale scores ≤ 21), and higher perceived stress (Sheldon Cohen Perceived Stress Scale scores ≥ 10)- and viral non-suppression (viral load ≥ 400 copies/mL) and loss to care (no documented clinic visits within the 90 days prior to survey), separately. A total of 359 YWH were included in this analysis. The median age of study participants was 21 (interquartile range: 16–23), and most were female (70.2%), single (82.4%), and attending school (54.7%). Over a quarter of participants (28.1%) had heightened depressive symptoms. Just 16.2% of all participants (n = 58) were lost to care at the time of survey, while 32.4% (n = 73) of the 225 participants with viral load data were non-suppressed. The prevalence of non-suppression in individuals with lower self-esteem was 1.71 (95% confidence interval: 1.12, 2.61) times the prevalence of non-suppression in those with higher self-esteem after adjustment. No meaningful association was observed between heightened depressive symptoms, lower social support, lower resilience, and higher perceived stress and viral non-suppression or loss to care in adjusted analyses. Retention in care and viral suppression among YWH in rural South Africa are below global targets. Interventions aimed at improving viral suppression among YWH should incorporate modules to improve participant’s self-esteem as low self-esteem is associated with viral non-suppression in this setting. Future studies should longitudinally explore the joint effects of co-occurring psychosocial stressors on HIV care outcomes in YWH and assess meaningful differences in these effects by age, gender, and route of transmission.
Real-world evidence from a University Hospital system regarding the uptake of adjuvant pertuzumab and/or neratinib before and after their FDA approval
Authors: Stoen Ericson , Kagihara Jodi , Shagisultanova Elena , Fisher Christine M. , Nicklawsky Andrew , Kabos Peter , Borges Virginia F. , Diamond Jennifer R. 
Published: February 2021

Abstract
Purpose
Adjuvant pertuzumab and neratinib are independently FDA-approved for treatment of early-stage HER2-positive breast cancer in combination with or following trastuzumab for one year, respectively. Both agents reduce the risk of recurrence; however, the absolute benefit is modest for many patients with added risk of adverse effects. The purpose of this study was to evaluate the clinical use of adjuvant pertuzumab and neratinib in patients with early-stage HER2-positive breast cancer.

Methods
Patients diagnosed with stage I–III HER2-positive breast cancer treated with trastuzumab at four University of Colorado Health hospitals between July 2016 and April 2019 were identified. Patient demographics, cancer stage, treatment, and administration of pertuzumab and/or neratinib were obtained.

Results
We identified a total of 350 patients who received adjuvant trastuzumab for stage I–III HER2-positive breast cancer; 253 (73.1%) had tumors that were ≥ T2 or node-positive disease. The rate of adjuvant pertuzumab use increased following FDA approval; pertuzumab was administered to the majority of patients with node-positive HER2-positive breast cancer. The use of adjuvant pertuzumab was associated with younger age, premenopausal status, and node-positive disease. Rates of administration of adjuvant neratinib were lower, with only 15.2% of patients receiving this therapy within 3 months of completing adjuvant trastuzumab.

Conclusion
In our cohort of patients treated within a diverse healthcare network, the majority of patients with node-positive HER2-positive breast cancer received adjuvant pertuzumab following FDA approval. The use of adjuvant neratinib was less common, potentially as a result of adverse effects, prolongation of therapy, previous administration of adjuvant pertuzumab, and modest benefit.