bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient Provider Continuity and Prostate Specific Antigen Testing: Impact of Continuity on Receipt of a Non-recommended Test
Authors: Mainous Arch G. , Rooks Benjamin J. , Mercado Elvira S. , Carek Peter J. 
Published: March 2021

Background: Continuity of care with a regular physician has been associated with treatment adherence but it is unclear if continuity of care may lead to inappropriate treatments. We assessed the relationship between the receipt of prostate-specific antigen (PSA) screening, a non-recommended test, and having continuity with a single personal doctor.Methods: We analyzed the 2016 and 2018 Behavioral Risk Factor Surveillance System (BRFSS). Responses from men aged 40 and older with no symptoms or family history of prostate cancer were analyzed (unweighted n = 232,548, representing 36,919,766 individuals). Continuity with one doctor was analyzed in relation to discussions of advantages and disadvantages of PSA tests, provider recommendation to receive a test and receipt of a PSA test.Results: 39.5% of men received PSA screening during the time that the test was not recommended. Having a single personal doctor was associated with discussion of both advantages (53.3 vs. 29.7%, p &lt; 0.001) and disadvantages (24.2 vs. 13.5%, p &lt; 0.001) of PSA tests but also a recommendation to receive a PSA test (45.3 vs. 29.3%, p &lt; 0.001). The adjusted odds of receiving a PSA test was higher among those with a single personal doctor compared to those without (OR 2.31; 95% CI, 2.17–2.46).Conclusion: In a nationally representative sample during the time when PSA screening was not recommended by the US Preventive Services Taskforce, having a single personal doctor was associated with both recommendations for the test and receipt of the test. These findings emphasize the importance of the patient physician relationship and the need for evidence-based care.
Analysis of Ovarian Injury Associated With COVID-19 Disease in Reproductive-Aged Women in Wuhan, China: An Observational Study
Authors: Ding Ting , Wang Tian , Zhang Jinjin , Cui Pengfei , Chen Zhe , Zhou Su , Yuan Suzhen , Ma Wenqing , Zhang Minli , Rong Yueguang , Chang Jiang , Miao Xiaoping , Ma Xiangyi , Wang Shixuan 
Published: March 2021

Objective: This study was intended to investigate the relationship between COVID-19 disease and ovarian function in reproductive-aged women.Methods: Female COVID-19 patients of reproductive age were recruited between January 28 and March 8, 2020 from Tongji Hospital in Wuhan. Their baseline and clinical characteristics, as well as menstrual conditions, were recorded. Differentials in ovarian reserve markers and sex hormones (including anti-Müllerian hormone [AMH], follicle-stimulating hormone [FSH], the ratio of FSH to luteinizing hormone [LH], estradiol [E2], progesterone [P], testosterone [T], and prolactin [PRL] were compared to those of healthy women who were randomly selected and individually matched for age, region, and menstrual status. Uni- and multi-variable hierarchical linear regression analyses were performed to identify risk factors associated with ovarian function in COVID-19 women.Results: Seventy eight patients agreed to be tested for serum hormone, of whom 17 (21.79%) were diagnosed as the severe group and 39 (50%) were in the basal level group. Menstrual status (P = 0.55), menstrual volumes (P = 0.066), phase of menstrual cycle (P = 0.58), and dysmenorrhea history (P = 0.12) were similar without significant differences between non-severe and severe COVID-19 women. Significant lower serum AMH level/proportion (0.19/0.28 vs. 1.12 ng/ml, P = 0.003/0.027; AMH ≤
1.1 ng/ml: 75/70.4 vs. 49.7%, P = 0.009/0.004), higher serum T (0.38/0.39 vs. 0.22 ng/ml, P &lt; 0.001/0.001) and PRL (25.43/24.10 vs. 12.12 ng/ml, P &lt; 0.001/0.001) levels were observed in basal level and the all-COVID-19 group compared with healthy age-matched control. When adjusted for age, menstrual status and parity variations in multivariate hierarchical linear regression analysis, COVID-19 disease was significantly associated with serum AMH (β = −0.191; 95% CI: −1.177–0.327; P = 0.001), T (β = 0.411; 95% CI: 11.154–22.709; P &lt; 0.001), and PRL (β = 0.497; 95% CI: 10.787–20.266; P &lt; 0.001), suggesting an independent risk factor for ovarian function, which accounted for 3.2% of the decline in AMH, 14.3% of the increase in T, and 20.7% of the increase in PRL.Conclusion: Ovarian injury, including declined ovarian reserve and reproductive endocrine disorder, can be observed in women with COVID-19. More attention should be paid to their ovarian function under this pandemic, especially regarding reproductive-aged women.Clinical Trial Number: ChiCTR2000030015.
Knockdown of SNORA47 Inhibits the Tumorigenesis of NSCLC via Mediation of PI3K/Akt Signaling Pathway
Authors: Yu Huiqing , Tian Ling , Yang Liejun , Liu Shihong , Wang Sixiong , Gong Juan 
Published: March 2021

BackgroundNon-small cell lung cancer (NSCLC) is a frequently diagnosed aggressive cancer all over the world. Small nucleolar RNAs (snoRNAs) are a group of non-coding mediatory RNAs. A previous report indicated that small nucleolar RNA 47 (SNORA47) is upregulated in NSCLC. However, the role of SNORA47 in NSCLC is unclear.Material and MethodsCell proliferation was measured by immunofluorescence staining. Cell apoptosis and cycle of NSCLC were tested by flow cytometry and the protein expressions were investigated by Western-blot. Meanwhile, cell migration and invasion were detected by transwell assay. Xenograft mice model was established to detect the effect of SNORA47 knockdown on tumor growth of NSLC in vivo.ResultsKnockdown of SNORA47 significantly inhibited the proliferation of NSCLC cells via inducing cell apoptosis. Moreover, migration and invasion of NSCLC cells were notably decreased by SNORA47 shRNA. SNORA47 knockdown significantly induced G1 arrest in NSCLC cells via regulation of p27 Kip1, CDK2, and cyclin D1. Meanwhile, SNORA47 shRNA inhibited EMT process and PI3K/Akt signaling in NSCLC cells. Finally, silencing of SNORA47 significantly inhibited the tumor growth of NSCLC in vivo.ConclusionKnockdown of SNORA47 significantly inhibited the tumorigenesis of NSCLC via inhibition of PI3K/Akt signaling and EMT process. Thereby, our finding might shed a new light on exploring the strategies for the treatment of NSCLC.
Complementing Prostate SBRT VMAT With a Two-Beam Non-Coplanar IMRT Class Solution to Enhance Rectum and Bladder Sparing With Minimum Increase in Treatment Time
Authors: Sharfo Abdul Wahab M. , Rossi Linda , Dirkx Maarten L. P. , Breedveld Sebastiaan , Aluwini Shafak , Heijmen Ben J. M. 
Published: March 2021

PurposeEnhance rectum and bladder sparing in prostate SBRT with minimum increase in treatment time by complementing dual-arc coplanar VMAT with a two-beam non-coplanar IMRT class solution (CS).MethodsFor twenty patients, an optimizer for automated multi-criterial planning with integrated beam angle optimization (BAO) was used to generate dual-arc VMAT plans, supplemented with five non-coplanar IMRT beams with individually optimized orientations (VMAT+5). In all plan generations, reduction of high rectum dose had the highest priority after obtaining adequate PTV coverage. A CS with two most preferred directions in VMAT+5 and largest rectum dose reductions compared to dual-arc VMAT was then selected to define VMAT+CS. VMAT+CS was compared with automatically generated i) dual-arc coplanar VMAT plans (VMAT), ii) VMAT+5 plans, and iii) IMRT plans with 30 patient-specific non-coplanar beam orientations (30-NCP). Plans were generated for a 4 x 9.5 Gy fractionation scheme. Differences in PTV doses, healthy tissue sparing, and computation and treatment delivery times were quantified.ResultsFor equal PTV coverage, VMAT+CS, consisting of dual-arc VMAT supplemented with two fixed, non-coplanar IMRT beams with fixed Gantry/Couch angles of 65°/30° and 295°/-30°, significantly reduced OAR doses and the dose bath, compared to dual-arc VMAT. Mean relative differences in rectum Dmean, D1cc, V40GyEq and V60GyEq were 19.4 ± 10.6%, 4.2 ± 2.7%, 34.9 ± 20.3%, and 39.7 ± 23.2%, respectively (all p&lt;0.001). There was no difference in bladder D1cc, while bladder Dmean reduced by 17.9 ± 11.0% (p&lt;0.001). Also, the clinically evaluated urethra D5%, D10%, and D50% showed small, but statistically significant improvements. All patient VX with X = 2, 5, 10, 20, and 30 Gy were reduced with VMAT+CS, with a maximum relative reduction for V10Gy of 19.0 ± 7.3% (p&lt;0.001). Total delivery times with VMAT+CS only increased by 1.9 ± 0.7 min compared to VMAT (9.1 ± 0.7 min). The dosimetric quality of VMAT+CS plans was equivalent to VMAT+5, while optimization times were reduced by a factor of 25 due to avoidance of individualized BAO. Compared to VMAT+CS, the 30-NCP plans were only favorable in terms of dose bath, at the cost of much enhanced optimization and delivery times.ConclusionsThe proposed two-beam non-coplanar class solution to complement coplanar dual-arc VMAT resulted in substantial plan quality improvements for OARs (especially rectum) and reduced irradiated patient volumes with minor increases in treatment delivery times.
Impact of the COVID-19 Pandemic on Patients and Staff in Radiation Oncology Departments in Belgium: A National Survey
Authors: Vaandering Aude , Ben Mustapha Selma , Lambrecht Maarten , Van Gestel Dirk , Veldmeman Liv 
Published: March 2021

Purpose: COVID-19 reached Belgium in February and quickly became a major public health challenge. It is of importance to evaluate the actual impact of COVID-19 on patients and staff in Belgian radiotherapy departments (RTDs). This was evaluated through a weekly national survey sent to departments measuring key factors that were affected by the pandemic.Materials and Methods: The Belgian SocieTy for Radiation Oncology (BeSTRO) together with the Belgian College for physicians in Radiation Oncology invited all 26 RTD to participate in a survey that started on March 2nd and was re- submitted weekly for 4 months to assess variations in time. The survey focused on: (1) the COVID-19 status of patients and staff; (2) the management of clinically suspected COVID patients and COVID positive patients; (3) the impact of COVID-19 on RTD activities; (4) its impact in radiotherapy indications and fractionation schemes.Results: Seventy-three percent of 26 RTDs completed the first survey and 57% responded to all weekly surveys. In the RTD staff, 24 members were COVID-positive of whom 67% were RTTs. Over the study period, the number of patients treated dropped by a maximum of 18.8% when compared to March 2nd. In 32.3% of COVID-positive and 54% of COVID suspected patients, treatment was continued without any interruptions. Radiotherapy indications were adapted within the 1st weeks of the survey in 47.4% of RTD, especially for urological and breast tumors. Fractionation schemes were changed in 68.4% of RTD, mainly for urological, breast, gastro-intestinal, and lung tumors.Conclusions: Between March and June 2020, the COVID-19 pandemic resulted in an important decrease in treatment activity in RTD in Belgium (18.8%). The COVID-19 infection status of patients influenced the continuity of the radiotherapy schedule. Changes in indications and fractionation schedules of radiotherapy were rapidly incorporated in the different RTD.
Mother-to-Infant Bonding in Women With a Bipolar Spectrum Disorder
Authors: Boekhorst Myrthe G. B. M. , Beerthuizen Annemerle , Hillegers Manon , Pop Victor J. M. , Bergink Veerle 
Published: March 2021

Purpose: Offspring of mothers with a bipolar disorder are at high-risk for impaired developmental outcomes and psychopathology (e. g., mood, anxiety, sleep disorders) later in life. This increased risk of psychopathology is not only because of genetic vulnerability, but environmental factors may play an important role as well. The often long and debilitating mood episodes of mothers with bipolar disorder might hamper their qualities as a caregiver and may impact the child. We examined early mother-to-infant bonding 1 year postpartum in mothers with bipolar spectrum disorder as compared to mothers of the general population. The association between mother-to-infant bonding and the type of bipolar spectrum diagnosis (bipolar I, bipolar II, bipolar Not Otherwise Specified) as well as relapse within 12 months postpartum was also assessed.Methods: In total, 75 pregnant women with a bipolar spectrum disorder participated in the current study. The participants were included in a longitudinal cohort study of women with bipolar spectrum disorder and were prospectively followed from pregnancy until 1 year postpartum. Mother-to-infant bonding was assessed using the Pre- and Postnatal Bonding Scale. A longitudinal population-based cohort of 1,419 pregnant women served as the control group. Multiple linear regression analyses were used to assess the association between bipolar spectrum disorder and mother-to-infant bonding scores, controlling for several confounders.Results: Women with bipolar spectrum disorder perceived the bonding with their child as less positive compared to the control group. The type of bipolar spectrum disorder was not associated with poorer bonding scores. Relapse during the 1st year after delivery also did not affect bonding scores in women with bipolar spectrum disorder.Conclusions: Our findings could imply that women with bipolar spectrum disorder are more vulnerable to impairments in bonding due to the nature of their psychopathology, regardless of the occurrence of postpartum relapse. Careful follow-up including monitoring of mother-to-infant bonding of pregnant women with a history of bipolar spectrum disorder should be a standard to this vulnerable group of women. In addition, regardless of severity and mood episode relapse, an intervention to improve bonding could be beneficial for all mothers with bipolar spectrum disorder and their newborns.
A Process-Model for Minimizing Adverse Effects when Using Head Mounted Display-Based Virtual Reality for Individuals with Autism
Authors: Schmidt Matthew , Newbutt Nigel , Schmidt Carla , Glaser Noah 
Published: March 2021

Interest in the use of virtual reality technologies for individuals with autism spectrum disorders has been increasing for over two decades. Recently, research interest has been growing in the area of head mounted display-based virtual reality technologies, thanks to increased availability and affordability. Affordances and theorized benefits of headset-based virtual reality for individuals with autism spectrum disorders are quite promising. However, very little attention has been given in the literature to implementation safety and ethics. This is a particular concern in light of documented adverse effects associated with headset-based virtual reality. To approach this gap, this article details how the authors approached the issue of minimizing adverse effects with related and overlapping methods, but from two separate, independent research sites—one in the United States and one in the United Kingdom. A structured within- and across-case analysis of the two independent studies was conducted to identify central implementation processes and procedures. Analysis resulted in development of a model for minimizing potential adverse effects of headset-based virtual reality for this population. We assert that our model could provide clarity in terms of design and implementation of headset-based virtual reality for individuals with autism spectrum disorders, guide implementations of future researchers and practitioners, and contribute to minimizing and controlling for potential adverse effects.
Abstrakcja, obiekty i cywilizacja globalna
Authors: Janusz Robert 
Published: March 2021

The article is about an interaction between philosophy and informatics. The discussion is based on a complex example - a country, which has an evolving domain. In contemporary computer science very complex systems are modeled. However it would be impossible to model such systems with every detail, because it would be too difficult, it would be as complex as the reality itself. Frequently complex domains don't have an exact description of their behavior: some have an inadequate description, some have a contradictory one. To model such complex domains a computer science specialist acts like a philosopher: makes classifications, explanations, etc. On the other hand there have to be some philosophical presuppositions - a conviction that a logical analysis and design will work in the domain being modeled: a postulate is introduced that logos is able to capture-in the reality. The descriptions
are continuously purified from irrational influences.
Józef Alojzy Dmowski SJ (1799-1879) Precursor of the Renewal of Thomism
Authors: Darowski Roman 
Published: March 2021

Józef Alojzy [Josephus Aloisius] Dmowski was one of the precursors of the nineteenth century renewal of Thomism and this was a few dozen years before the promulgation of Pope Leo XIII's encyclical, Aeterni Patris (1879). He was one of the most famous Christian philosophers of the nineteenth century. His work was also the first extensive philosophy textbook of that time which included a l l the disciplines of the time, published by the Jesuits after the re-establishment of the Order in 1814. (The suppression took place in 1773). Until now Dmowski's philosophy has not been the subject of an extensive study. I aim to remedy this in the present article.
Dan Lloyd. Radiant Cool. A Novel Theory of Consiousness [Promienienny chłód. Nowa teoria świadomości]
Authors: Bremer Józef 
Published: March 2021

Dan Lloyd jest profesorem filozofii w Trinity College (Hartford w Connecticut). Tytuł i motto omawianej książki nawiązuje do wiersza Allena Ginsberga „Skowyt" [„Widziałem najwspanialsze umysły mego pokolenia, zniszczone obłędem, ... którzy ukończyli uniwersytety chłodnym promiennym okiem..." (with radiant cool eyes)]. Książka Radiant Cool jest napisana prostym językiem, chociaż pojawia się w niej wiele neurofenomenologicznego „żargonu", co może zniechęcać do dalszej lektury. Książka dostarcza dobrego wprowadzenia do fenomenologii Husserla i do debat obecnych we współczesnej, angloamerykańskiej filozofii świadomości, odwołujących się do wyników badan neurologicznych. Można ją polecić studentom filozofii, psychologii oraz neurologii. Wprowadzający charakter książki podkreślają liczne schematy, wytłuszczenia, wcięcia tekstu, tabelki itp., mające unaocznić główne toki rozumowania. Cechy ujemny takich schematów i rysunków jest to, ze równocześnie zawyżają one pole rozumienia i sprawiają wrażenie, że tak naprawdę, to problem świadomości już został rozwiązany. Dlatego podczas czytania Radiant Cool należy ciągle pamiętać, że tezy Lloyda są z założenia „optymistyczne" i mają informacyjno-komercyjny (infomercial) charakter.
Wojciech Słomski. W stronę człowieka, Wokół koncepcji filozofii Antoniego Kępińskiego [In the direction of man. About Antoni Kępiński's conception of philosophy]
Authors: Czarnecki Paweł Stanisław 
Published: March 2021

Assuming, according to Jaspers, that the measure of truth of a philosophical system is the lifestyle of its creator as well as his ability at drawing conclusions resulting from philosophical speculation to the requirements of practical action, the question must be asked, to what extent, if at all Wojciech Słomski's book tries to recognise and name the philosophically characteristic merging of theory and practise. Despite this, it shouldn't be the superior aim of any biography, let alone the biography of a philosopher (where this kind of behaviour would force the author to take up the position of a judge for whom the reproducing of a true biography is a process coming close to producing a final verdict). However in the case of Professor Antoni Kępiński, the connection between theoretical views and real life holds meaning not only for judging the truth of these views but most of all for a correct understanding of them.
II concetto di legge nella Summa theologiae di San Tommaso d'Aquino
Authors: Majkrzak Henryk 
Published: March 2021

San Tommaso d'Aquino ha trattato della legge in generale e della legge naturale in particolare in numerosi scritti, ma soprattutto nella Summa theologiae. Egli ha posto in evidenza il carattere razionale della legge: se la legge esprime un ordine dell'essere, essa non puo non essere l'espressione di un'intelligenza: „rationis est enim ordinare ad finem''. Secondo lui la legge e un comando della ragione ordinato al bene comune, promulgato da chi e incaricato di una comunita: „Quaedam rationis ordinatio ad bonum commune, ab eo qui curam communitatis habet promulgata''. Questa definizione della legge si realizza, analogicamente, nei diversi tipi di legge. Nella sua definizione l'Aquinate da grande rilievo a due caratteri fondamentali della legge: la razionalita e l'universalitä. La legge e opera della ragione (rationis ordinatio). Infatti la legge e una norma direttiva dell'agire umano in ordine al fine dell'uomo. Bisogna conoscere il fine e il rapporto dei mezzi al fine, in modo da scegliere i piu adatti e stabilire il miglior piano di esecuzione: e questo e compito proprio della ragione. La legge deve avere di mira il bene comune e per questo deve possedere carattere universale. II bene comune e il bene di una comunita di persone ed e quindi relative alla natura della comunita, a cui si riferisce.
History of Philosophy in Lithuania (I)
Authors: Plečkaitis Romanas 
Published: March 2021

The academic History of Philosophy in Lithuania in three volumes will be published by the Institute of Culture, Philosophy and Art. The first presented volume covers the development of Lithuanian philosophy from the 16th to the 18th centuries. It includes late medieval and Renaissance philosophy, the second scholasticism and modern philosophy. The first Lithuanians to be introduced to philosophy were young members of the gentry who studied in European universities at the end of the 14th century. The recently baptized Lithuania strove to adopt Western culture and to present itself as a Western state. Some graduated from the universities as bachelors or masters of philosophy and returned to their country. At the end of the 14th century, Vilnius Cathedral School was founded. The elements of logic were probably taught there. The growth of the political and economic power of the Grand Duchy
of Lithuania brought about the need for higher education. That need was significantly increased by the growing activity of various religious orders. In 1507 the Dominicans started teaching philosophy and theology
to their novices. They were able to teach late medieval philosophy in its thomistic interpretation. We can regard 1507 as the year Lithuania benefited form a new phenomenon, professional philosophy, and the Dominicans
as its initiators. They taught not only the disciplines of late medieval philosophy but also the basics of the other sciences. The Dominicans, and later the Jesuits, Franciscans, Bernardines, Carmelites, Trinitarians and other monastic orders, enriched intellectual life in Lithuania by teaching philosophy in their schools.
Powszechna Encyklopedia Filozofii
Authors: Ziemiański Stanisław 
Published: March 2021

The fifth volume of the Universal Encyclopaedia of Philosophy [Powszechna Encyklopedia Filozofii] has been edited in September 2004 by the St. Thomas Aquinas Society in Poland (Section of Societa Internazionale Tommaso d'Aquino) under the auspices of the Department of Metaphysics at the Catholic University in Lublin. The grand volume of 934 pages contains entries beginning with the letters Iq-J-Ko. The Universal Encyclopaedia of Philosophy [UEP] has been out since 2000 in Lublin. It is the first philosophical encyclopaedia in the whole history of Polish academic activity, and the fifth such publication world-wide.