bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Workplace Social Capital and Neck Pain
Authors: Tezuka Masato , Saeki Kenta , Nakatsuka Kiyomasa , Uchida Kazuaki , Horibe Kana , Goto Ryo , Encho Haruhi , Tamura Kazuya , Mukaijo Mao , Yamada Naoki , Ono Rei 
Published: December 2021

Objective:
We examined the association between workplace social capital (WSC) and presence of neck pain (NP) among workers.

Methods:
This cross-sectional study included 595 workers. Presence of NP was assessed using Numerical Rating scale. WSC (overall, bonding, bridging, and linking) was divided into three categories (low, middle, and high) based on tertile distributions. We used logistic regression analysis to investigate the association between WSC and presence of NP.

Results:
Low overall, bonding, and linking social capital were significantly associated with presence of NP in comparison with each high social capital (overall: adjusted odds ratio [aOR] = 1.76, 95% confidence interval [CI] = 1.14 to 2.73; bonding: aOR = 1.78, 95% CI = 1.19 to 2.67, linking: aOR = 2.18, 95% CI = 1.32 to 3.63).

Conclusion:
Lower WSC had an association with higher prevalence of NP among workers.
Guided growth: indications and techniques for correction of knock knees and bowlegs
Authors: Tuca María , Franz Pia , Guerra Daniela , Sepúlveda Matías 
Published: December 2021

Purpose of review
Lower extremities axis alterations are a frequent cause for consultation in the medical practice of the care of paediatric patients. When it corresponds to pathological situations, guided growth surgery has been positioned as a possibility of well tolerated, reproducible and predictable resolution. For this reason, its use has increased significantly in recent years. In this review, its current indications, preoperative study, results and complications described in the updated literature will be discussed.

Recent findings
The success of the technique remains high in the current literature, expanding the technique to other segments and disorders, and describing new ways of performing tension band with sutures. In addition, there is an increase in its incidence and a decrease in the associated hospitalized days, which can associate with techniques of lower morbidity.

Summary
As guided growth surgery allows for successful correction of axis alterations, to achieve this, it is important to know the main indications, preoperative analysis and theoretical bases on which this technique is based, to carry it out in an adequate and timely manner, seeking an adequate resolution of the child's problem.
Coccidioides immitis
Authors: Amoth Haley , Kemp Walter L. 
Published: December 2021

Abstract

Coccidioides immitis is a dimorphic fungus, growing as a fungus in the soil and as a yeast in the human body, that is geographically limited in the United States, being most commonly associated with the San Joaquin Valley and found in California and Arizona. In most individuals, infection with C. immitis causes an asymptomatic, self-limited pulmonary infection; however, in a small percentage of individuals, the infection is disseminated and can involve any organ. We present the case of a 50-year-old man who was found unresponsive in his home in the northern portion of the United States. Autopsy revealed a 2163-g spleen. The initial differential diagnosis for the splenomegaly was an infection or a neoplastic process, such as leukemia. Because of the geographic location where the body was found, C. immitis was not initially considered; however, microscopic examination confirmed the presence of C. immitis spherules, which were found in the spleen and other organs. Granulomatous inflammation, often associated with spherules, was also present in a kidney, the pancreas, the thyroid gland, a parathyroid gland, and the heart. Additional investigation after the autopsy revealed that the decedent had spent time in the past in California, which would have allowed for exposure to C. immitis. The decedent had a rare form of a disease process not normally associated with the geographic location in which he was found, which highlights the need for continued diligence in death investigation so as to not allow a first impression to impair the correct final determination.
Flow-Through Arterialized Posterior Interosseous Nerve Grafts for Digital Neurovascular Bundle Defects: Anatomical Study
Authors: Claro Gilles , Zelenski Nicole A. , Balaguer Thierry , Chaput Benoit , Isola Nicolas , Baqué Patrick , Bronsard Nicolas , Camuzard Olivier 
Published: December 2021

Background:
Digital neurovascular bundle defects are often encountered during crush or avulsion injuries and require complex reconstruction. Use of an arterialized nerve graft (neurovascular graft) serving both as an interpositional arterial conduit and as a nerve graft could be a reconstructive option in these cases. In this anatomical study, the authors aimed to describe a neurovascular graft of the posterior interosseous nerve and a branch of the anterior interosseous artery for neurovascular bundle reconstruction of the fingers.

Methods:
Eighteen forearms were injected with red latex in order to collect the anatomical characteristics of the posterior interosseous nerve and the artery running near it.

Results:
In all cases, the posterior interosseous nerve was followed by a branch of the anterior interosseous artery: the distal dorsal branch of the anterior interosseous nerve. The origin of this artery was proximal to the radiocarpal joint, at an average of 56.5 ± 11.1 mm. The proximal and distal diameters of the branch of the anterior interosseous artery were 1.6 ± 0.2 and 1.1 ± 0.2 mm, respectively. The proximal and distal diameters of the posterior interosseous nerve were 1.2 ± 0.3 mm and 1.1 ± 0.3 mm, respectively.

Conclusions:
These results show that a potential free neurovascular graft using the posterior interosseous nerve as nerve graft and the anterior interosseous artery as an arterial bypass to reconstruct both the nerve and arterial tree of the finger could be a useful approach. The authors speculate that this graft could be used to reconstruct the neurovascular bundle of amputated or devascularized digits.
Should Antiplatelet Therapy Be Withheld Perioperatively? The First Study Examining Outcomes in Patients Receiving Dual Antiplatelet Therapy in the Lower Extremity Free Flap Population
Authors: Mishu Mark D. , Zolper Elizabeth G. , Dekker Paige K. , Fleury Christopher M. , Bekeny Jenna C. , Fan Kenneth L. , Attinger Christopher E. , Evans Karen K. 
Published: December 2021

Background:
Antiplatelet agents are typically withheld perioperatively because of bleeding concerns. Dual antiplatelet therapy, such as aspirin and clopidogrel, has significant morbidity and mortality benefits in patients with ischemic heart disease or peripheral vascular disease. This study aims to evaluate the impact of perioperative dual antiplatelet therapy in the lower extremity free tissue transfer population.

Methods:
Lower extremity free tissue transfers performed by the senior author (K.K.E.) from 2011 to 2019 were retrospectively reviewed. Demographics, comorbidities, perioperative dual antiplatelet therapy, and free tissue transfer characteristics were recorded. Outcomes of interest included flap success, hematoma formation, blood transfusion requirements, and cardiac event occurrence.

Results:
One hundred ninety-five free tissue transfers were included. Median age at the time of free tissue transfer was 56.5 years. Median Charlson Comorbidity Index was 3. Thirty-four patients were on clopidogrel, which was either withheld (n = 20) or continued (n = 14) on the day of free tissue transfer. Incidence of blood transfusion was significantly higher in both the withheld and continued versus nonclopidogrel groups. Flap success was statistically equivalent between groups (withheld, 90.0 percent; continued, 92.9 percent; nonclopidogrel, 95.0 percent; p = 0.346). Cardiac events occurred most often in the continued group (21.4 percent) compared to the withheld (5.0 percent) and nonclopidogrel (0.6 percent) groups. On multivariate analysis, holding clopidogrel remained significant for increased odds of postoperative transfusion. The clopidogrel group was no longer significant for intraoperative transfusion.

Conclusions:
Despite increases in volume of blood products transfused, free tissue transfer can be performed safely with perioperative dual antiplatelet therapy. Withholding dual antiplatelet therapy on the day of free tissue transfer was not associated with decreased intraoperative transfusion; thus, dual antiplatelet therapy can safely be continued throughout the operative course to minimize cardiovascular risk.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, III.
Anatomy of the Breast Fascial System: A Systematic Review of the Literature
Authors: Duncan Anna M. , Al Youha Sarah , Joukhadar Nadim , Konder Ricarda , Stecco Carla , Wheelock Margaret E. 
Published: December 2021

Background:
Understanding the anatomy of the fascial and ligamentous structures of the breast is important in both aesthetic and reconstructive breast surgery. Several structures have been identified that play a significant role in the aesthetic qualities and support of the breast warranting consideration in the context of breast reconstruction.

Methods:
The authors performed a systematic review of anatomical, clinical, histologic, and radiologic studies that have described, characterized, and named these structures. The authors have summarized and critically appraised prior research to clarify and define the key fascial structures of the breast, their anatomical function, and their clinical significance in aesthetic and reconstructive breast surgery.

Results:
Through their review, six distinct breast fascial structures were encountered consistently in the literature. The authors have organized them into intraglandular and extraglandular structures and have reviewed their significance in the context of reconstructive breast surgery.

Conclusions:
The primary fascial structures of the breast are important anatomical landmarks with numerous clinical applications. Cooper ligaments divide the breast parenchyma. The superficial and deep layers of the superficial fascia encase the breast in a “pocket,” condensing into one thickened layer of fascia along the peripheral breast footprint. The inframammary fold supports and defines the inferior pole. The horizontal septum is a reliable neurovascular landmark. The vertical septum is a newly discovered fascial structure. There are certainly clinical implications that have yet to be described because of the relatively limited and disputed information on the fascia of the female breast and, ultimately, more research is warranted.
Exercise after Breast Augmentation: A Randomized Controlled Trial
Authors: Basile Filipe V. , Oliveira Thais S. 
Published: December 2021

Background:
There are limited scientific data regarding the impact of exercise after breast augmentation surgery. Recommendations range from a few weeks to a few months of physical activity avoidance. To decide whether early exercise after breast augmentation is safe, a prospective randomized trial was designed to measure complications, scar quality, and patient-reported outcomes in this setting.

Methods:
The present study was a randomized controlled trial to investigate the effects of early exercise (1 week after surgery) on postoperative complications, scar quality, and patient-reported outcome (BREAST-Q). All women undergoing primary breast augmentation surgery in the authors’ institution were randomized to either standard restrictions or exercise. The three primary outcomes measured were the presence of a complication and reoperation, scar quality, and patient-reported outcome.

Results:
A total of 225 participants were included in the final analysis. No differences were found among the groups for age (p = 0.66), implant size (p = 0.56), or implant pocket (p = 0.29); complication rates did not change between the control (7.5 percent) and exercise groups (6.9 percent). When assessed 12 months after surgery, the scar quality was comparable between the groups (29.9 control and 29.6 exercise, p = 0.204). Intervention groups (exercise) performed better on the BREAST-Q Augmentation Module: Satisfaction with Outcome score (66.3 control and 83.4 exercise, p < 0.01).

Conclusions:
Early exercise following primary breast augmentation does not increase complication or reoperation rates or cause a reduction in scar quality after 1 year. In addition, a patient-reported outcome showed improvement in the exercise groups.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, II.
TULUA Male High-Definition Abdominoplasty
Authors: Babaitis Ricardo , Villegas Francisco J. , Hoyos Alfredo E. , Perez Mauricio , Mogollon Ivan R. 
Published: December 2021

Background:
Abdominoplasty is a surgical technique for body contouring that has been shown to improve the patient’s quality of life. It has become more common among male patients, so clear differences between procedures for men and women have to be stated. The authors present their experience with high-definition lipoabdominoplasty with transverse plication in men.

Methods:
Records of male patients undergoing transverse plication full abdominoplasty in addition to high-definition liposculpture were analyzed. A total of 24 consecutive cases were found between January of 2017 and June of 2019. Patient ages ranged from 24 to 60 years. Patients aged 18 years or younger were excluded. Body mass index ranged from 25 to 33 kg/m2. Photographic records were taken before and during follow-up at 2 days and 1, 3, 6, and 12 months after surgery.

Results:
Male TULUA (transverse plication, no undermining, full liposuction, neoumbilicoplasty, and low transverse abdominal scar) with high-definition lipoabdominoplasty was successfully achieved in 24 cases. No major complications were reported. Six minor complications were reported (25 percent). Rectus abdominis diastases are less common in men compared to women, as pregnancy is the most determining factor in its development. Fat distribution is also a key difference when performing lipoabdominoplasty for the male or the female patient. The authors recommend a transverse plication of the abdominal wall, instead of a vertical one, as flap viability is preserved and enhanced muscular definition can be accomplished.

Conclusions:
Combining transverse plication with high-definition lipoabdominoplasty (transverse plication, no undermining, full liposuction, neoumbilicoplasty, and low transverse abdominal scar plus high-definition lipoabdominoplasty) is a safe and reproducible technique for the male patient. It offers higher aesthetic results in line with modern beauty ideals.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, IV.
Anal cancer incidence in men with HIV who have sex with men: are black men at higher risk?
Authors: McNeil Candice J. , Lee Jennifer S. , Cole Stephen R. , Patel Shivani A. , Martin Jeffrey , Mathews William C. , Moore Richard D. , Mayer Kenneth H. , Eron Joseph J. , Saag Michael S. , Kitahata Mari M. , Achenbach Chad J. 
Published: December 2021

Objective:
To assess differences in anal cancer incidence between racial/ethnic groups among a clinical cohort of men with HIV who have sex with men.

Design:
Clinical cohort study

Methods:
We studied men who have sex with men (MSM) in the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) who initiated antiretroviral therapy (ART) under HIV care in CNICS. We compared anal cancer incidence between Black and non-Black men and calculated hazard ratios controlling for demographic characteristics (age, CNICS site, year of ART initiation), HIV disease indicators (nadir CD4+, peak HIV RNA), and co-infection/behavioral factors including hepatitis B virus (HBV), hepatitis C virus (HCV), tobacco smoking and alcohol abuse.

Results:
We studied 7473 MSM with HIV who contributed 41 810 person-years of follow-up after initiating ART between 1996 and 2014 in CNICS. Forty-one individuals had an incident diagnosis of anal cancer under observation. Crude rates of anal cancer were 204 versus 61 per 100 000 person-years among Black versus non-Black MSM. The weighted hazard ratio for anal cancer in Black MSM (adjusting for demographics, HIV disease factors, and co-infection/behavioral factors) was 2.37 (95% confidence interval: 1.17, 4.82) compared to non-Black MSM.

Conclusions:
In this large multicenter cohort, Black MSM were at significantly increased risk for anal cancer compared to non-Black MSM. Further detailed studies evaluating factors impacting anal cancer incidence and outcomes in Black men with HIV are necessary. Inclusion of more diverse study cohorts may elucidate modifiable factors associated with increased anal cancer risk experienced by Black MSM.
Incidence of lung and human papilloma virus-associated malignancies in HIV-infected patients
Authors: Chaussade Hélène , Le Marec Fabien , Coureau Gaëlle , Leleux Olivier , Neau Didier , Lazaro Estibaliz , Amadeo Brice , Duffau Pierre , Ferrand Hélène , Courtault Carine , Foucan Anne-Sophie , Wittkop Linda , Bonnet Fabrice 
Published: December 2021

Objective:
Cancers represent one of the leading cause of mortality/morbidity in patients with HIV (PWH) in industrialized countries. The objective of our study was to compare incidence of lung and human papilloma virus (HPV)-related cancers among PWH with general population over the 2010–2017 period.

Design:
Prospective and multicenter cohort study.

Methods:
The study included patients with lung and HPV-related cancers from the ANRS CO3 Aquitaine cohort (PWH) and the general population-based cancer registry in Gironde area. We calculated incidence rates for 100 000 person-years and incidence rate ratios (IRR).

Results:
Among the 3572 PWH, 70 cancers were diagnosed in 68 patients including 35 lung and 35 HPV-related cancers (18 oropharyngeal, 11 anal, 6 cervix). Incidence rates of lung and HPV-related-cancers were 311.1 in PWH and 209.8 in general population for 100 000 person-years, respectively. IRR were significantly increased in PWH for lung 1.8 [1.4–2.2] and HPV-related cancer 1.3 [1.0–1.6] and particularly high for patients between 40 and 49 years old [IRR 4.4 (2.3–8.4) for lung cancer and 3.7 (2.1–6.5) for HPV-related cancer].

Conclusion:
We emphasized the persistent high risk of lung and HPV-related cancer despite advent of antiretroviral therapies, particularly in the age strata of 40–49 years. Screening procedures should take into account this finding.
Deep Learning Algorithm for Fully Automated Detection of Small (≤4 cm) Renal Cell Carcinoma in Contrast-Enhanced Computed Tomography Using a Multicenter Database
Authors: Toda Naoki , Hashimoto Masahiro , Arita Yuki , Haque Hasnine , Akita Hirotaka , Akashi Toshiaki , Gobara Hideo , Nishie Akihiro , Yakami Masahiro , Nakamoto Atsushi , Watadani Takeyuki , Oya Mototsugu , Jinzaki Masahiro 
Published: December 2021

Objectives
Renal cell carcinoma (RCC) is often found incidentally in asymptomatic individuals undergoing abdominal computed tomography (CT) examinations. The purpose of our study is to develop a deep learning-based algorithm for fully automated detection of small (≤4 cm) RCCs in contrast-enhanced CT images using a multicenter database and to evaluate its performance.

Materials and Methods
For the algorithmic detection of RCC, we retrospectively selected contrast-enhanced CT images of patients with histologically confirmed single RCC with a tumor diameter of 4 cm or less between January 2005 and May 2020 from 7 centers in the Japan Medical Image Database. A total of 453 patients from 6 centers were selected as dataset A, and 132 patients from 1 center were selected as dataset B. Dataset A was used for training and internal validation. Dataset B was used only for external validation. Nephrogenic phase images of multiphase CT or single-phase postcontrast CT images were used. Our algorithm consisted of 2-step segmentation models, kidney segmentation and tumor segmentation. For internal validation with dataset A, 10-fold cross-validation was applied. For external validation, the models trained with dataset A were tested on dataset B. The detection performance of the models was evaluated using accuracy, sensitivity, specificity, and the area under the curve (AUC).

Results
The mean ± SD diameters of RCCs in dataset A and dataset B were 2.67 ± 0.77 cm and 2.64 ± 0.78 cm, respectively. Our algorithm yielded an accuracy, sensitivity, and specificity of 88.3%, 84.3%, and 92.3%, respectively, with dataset A and 87.5%, 84.8%, and 90.2%, respectively, with dataset B. The AUC of the algorithm with dataset A and dataset B was 0.930 and 0.933, respectively.

Conclusions
The proposed deep learning–based algorithm achieved high accuracy, sensitivity, specificity, and AUC for the detection of small RCCs with both internal and external validations, suggesting that this algorithm could contribute to the early detection of small RCCs.
Does healthy lifestyle attenuate the detrimental effects of urinary polycyclic aromatic hydrocarbons on phenotypic aging? An analysis from NHANES 2001–2010
Authors: Yang Zhenqing , Pu Fan , Cao Xingqi , Li Xueqin , Sun Sudan , Zhang Jingyun , Chen Chen , Han Liyuan , Yang Yongli , Wang Wei , Zhang Yawei , Liu Zuyun 
Published: December 2021

AbstractObjectivesIt remains unknown whether healthy lifestyle attenuates the detrimental effects of urinary monohydroxy polycyclic aromatic hydrocarbons (OH-PAHs) on aging. This study aims: 1) to examine the associations of OH-PAHs and lifestyle with Phenotypic Age Acceleration (PhenoAge.Accel), a novel aging measure, respectively; and 2) to evaluate the potential interaction effects of OH-PAHs and lifestyle on PhenoAge.Accel.MethodsCross-sectional data of 2579 participants (aged 20-84 years, n=1292 females) from the National Health and Nutrition Examination Survey for years 2001-2010 were analyzed. A lifestyle index was constructed based on five components (drinking, smoking, body mass index, physical activity, and diet), ranging from 0 to 5. We calculated PhenoAge.Accel using algorithms developed previously. General linear regression models were used to examine the associations.ResultsWe observed strong associations of OH-PAHs and lifestyle with PhenoAge.Accel. For instance, one unit increase in ∑NAP (sum of 1- and 2-hydroxynaphthalene) was associated with 0.37 year (95% confidence interval [CI]: 0.26, 0.48) increase in PhenoAge.Accel. We did not observe statistically significant interaction effects between OH-PAHs and lifestyle on PhenoAge.Accel. After stratified by sex, we observed strong associations as well as statistically significant interactions of OH-PAHs and lifestyle with PhenoAge.Accel among females.ConclusionsBoth OH-PAHs and lifestyle were independently associated with phenotypic aging and there were statistically significant interactions between OH-PAHs and lifestyle on phenotypic aging among females. The findings highlight the importance of adherence to a healthy lifestyle to attenuate the detrimental effects of exposures to PAHs on phenotypic aging among females.