bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful Closure of the Tip of the “J” Fistula of the Ileal Pouch With Double Over-the-Scope Clips
Authors: Lescaille Yaniuska , Rosh Joel R. , Kiran Ravi P. , Shen Bo 
Published: May 2021

ABSTRACT
Ileal pouch-anal anastomosis is the surgical procedure of choice for patients who require colectomy for complicated ulcerative colitis with or without associated dysplasia and familial adenomatous polyposis. Leaks from the suture lines or anastomosis can lead to pouch failure. Treatment options have been radiographic drainage and surgical intervention. Endoscopic therapy has emerged a viable nonsurgical treatment option for some of the complications associated with J-pouch surgery. Here, we present a case of endoscopic management of a leak from the tip of the J-pouch with sequential application of 2 over-the-scope clips.
Rumbos de la tecnoescena pandémica
Authors: Hernández Moira Gisela , Catrihuala Carlos Omar 
Published: May 2021

El COVID 19 y la consecuente política de aislamiento adoptada por los países del mundo tuvieron distintas repercusiones en la vida social.
En el campo del teatro y las artes escénicas, existen dos modos de mirar el mismo evento: una mirada tecnofóbica que proclama la naturaleza del teatro como una coexistencia efectiva entre actor y público, reivindicando ese vínculo casi como estado aurático; y por otro lado, la mirada de quienes ven en esta situación una posibilidad de explorar textualidades virtuales, es decir, una evolución teatral ligada a la tecnología. Los primeros sostienen que esta desmaterialización del teatro provoca una pérdida de sentido que socava su carácter social y los segundos, una alternativa poco explorada por la escena teatral, pero no para la performance o la poética liminal.
La obra que analizamos, La maldición de la corona del grupo catalán La Fura Dels Baus, considera a la tecnología inseparable de la evolución social y por lo tanto teatral. De los pensamientos teatrales más puristas anclados en la convivencia pasamos a la noción de tecnoescena y la consecuente vida virtual de las obras artísticas.
La política educativa de la democracia en España (1978-2019): Escolarización, conflicto Iglesia-Estado y calidad de la educación
Authors: Merchán Iglesias F. Javier 
Published: May 2021

Se estudia en este artículo la trayectoria de la política educativa en España desde los primeros pasos de la restauración de la democracia hasta nuestros días. Partiendo de la situación heredada del régimen franquista, se desarrolla la tesis de que esa política ha girado en torno a tres grandes asuntos. Por una parte, la escolarización, por otra, el conflicto entre el Estado y la Iglesia por el control del sistema educativo y, en fin, la cuestión de la denominada calidad de la educación. Tras examinar el proceso que conduce a la plena escolarización hasta los dieciséis años, se analizan las circunstancias en las que se desarrolla la pugna entre la enseñanza pública y la privada, las posiciones que al respecto mantuvieron los principales grupos políticos y sociales, así como el pacto implícito que provisionalmente resolvió la confrontación y configura la actual estructura de la educación en España. En cuanto a la mejora de la calidad, se analizan las dos grandes estrategias desarrolladas en estos años, la que llamamos reforma pedagógica – vinculada al modelo de la escuela comprensiva – y la que identificamos como gestión empresarial de la escuela, relacionada con la hegemonía del pensamiento conservador y la mundialización de la política educativa.
Positive radial symmetric solutions for a class of elliptic problems with critical exponent and -1 growth
Authors: Lei Chun-Yu , Liao Jia-Feng 
Published: May 2021

Abstract
In this paper, we consider a class of semilinear elliptic equation with critical exponent and -1 growth. By using the critical point theory for nonsmooth functionals, two positive solutions are obtained. Moreover, the symmetry and monotonicity properties of the solutions are proved by the moving plane method. Our results improve the corresponding results in the literature.
Templated α-Synuclein Inclusion Formation Is Independent of Endogenous Tau
Authors: Stoyka Lindsay E. , Mahoney Casey L. , Thrasher Drake R. , Russell Drèson L. , Cook Anna K. , Harris Anner T. , Narayanan Ashwin , Janado Tiara P. , Standaert David G. , Roberson Erik D. , Volpicelli-Daley Laura A. 
Published: May 2021

AbstractSynucleinopathies including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are characterized by neuronal intracellular inclusions of α-synuclein. PD dementia (PDD) and DLB are collectively the second most common cause of neurodegenerative dementia. In addition to associated inclusions, Lewy body diseases (LBDs) have dopaminergic neurodegeneration, motor defects and cognitive changes. The microtubule-associated protein tau has been implicated in LBDs, but the exact role of the protein and how it influences formation of α-synuclein inclusions is unknown. Reducing endogenous tau levels is protective in multiple models of Alzheimer’s disease (AD), tauopathies, and in some transgenic synucleinopathy mouse models. Recombinant α-synuclein and tau proteins interactin vitro. Here, we show tau and α-synuclein colocalize at excitatory presynaptic terminals. However, tau heterozygous and tau knock-out mice do not show a reduction in fibril-induced α-synuclein inclusions formation in primary cortical neurons, or after intrastriatal injections of fibrils at 1.5 month or six months later. At six months following intrastriatal injections, wild-type, tau heterozygous and tau knock-out mice showed a 50% reduction in dopamine neurons in the substantia nigra pars compacta (SNc) compared with mice injected with α-synuclein monomer, but there were no statistically significant differences across genotypes. These data suggest the role of tau in the pathogenesis of LBDs is distinct from AD, and Lewy pathology formation may be independent of endogenous tau.
Detection of NDM-1 producing Klebsiella pneumoniae ST15 and ST147 in Iran during 2019–2020
Authors: Rad Zohreh Riahi , Rad Zahra Riahi , Goudarzi Hossein , Goudarzi Mehdi , Alizade Hesam , Mazraeh Fariba Naeimi , Sharahi Javad Yasbolaghi , Ardebili Abdollah , Hashemi Ali 
Published: May 2021

AbstractCarbapenems are employed to treat infections caused by Gram-negative bacteria including Klebsiella pneumoniae. This research is aimed to perform phenotypic detection of β-lactamases and molecular characterization of NDM-1 positive K. pneumoniae isolates. Another objective is to investigate NDM-1 producing K. pneumoniae among children in Iran. From 2019 to 2020, altogether 60 K. pneumoniae isolates were acquired from various patients in certain Iranian hospitals. Antimicrobial susceptibility testing was performed by disk diffusion and broth microdilution methods. In addition, mCIM and eCIM were used to confirm the production of carbapenemases and metallo-beta-lactamases (MBLs), respectively. Detection of resistance genes namely, blaNDM-1, blaIMP, blaVIM, blaKPC, blaOXA-48-like, blaCTX-M, blaSHV, blaTEM, and mcr-1 was performed by PCR and confirmed by DNA sequencing. Multilocus sequence typing (MLST) was employed to determine the molecular typing of the strains. According to the findings, the highest rate of carbapenem resistance was detected against doripenem 83.3% (50). Moreover, 31.7% (19) were resistant to colistin. Further to the above, altogether 80% (48) were carbapenemase-producing isolates and among them 46.7% (28) of the isolates were MBL and 33.3% (20) isolates were serine β-lactamase producer. According to the PCR results, 14 isolates produced blaNDM-1. Remarkably, four blaNDM-1 positive isolates were detected in children. In addition, these isolates were clonally related as determined by MLST (ST147, ST15). Altogether ten blaNDM-1 positive isolates were ST147 and four blaNDM-1 positive isolates were ST15. Based on the results, the emergence of NDM-producing K. pneumoniae among children is worrying and hence, it is necessary to develop a comprehensive program to control antibiotic resistance in the country.
Masonry walls retrofitted with natural fibers under tsunami loads
Authors: Fabbrocino Francesco , Belliazzi Stefano , Ramaglia Giancarlo , Lignola Gian Piero , Prota Andrea 
Published: May 2021

AbstractIn the last decades, several tsunamis hit international coasts and engaged scientific awareness to the retrofit of coastal buildings against tsunami loads. Structural design under tsunami loads is difficult due to the high uncertainties of the phenomenon. Local collapse mechanisms of masonry walls, like as out of plane mechanisms, have an high probability due to flexural actions; a higher flexural capacity can be reached using specific retrofit systems; in particular, this paper aims to deepen the behavior of masonry walls retrofitted with innovative retrofit systems like as natural fibers applied with inorganic mortar matrices. The retrofit of structures under tsunami actions could be an innovative research topic for international research community dealing with coastal buildings located in areas characterized by a high tsunami risk. Recent engineering applications demonstrated the innovative strengthening systems to be effective for the retrofit of existing masonry buildings. These strengthening systems are of great interest in the practical applications due to the low costs and their sustainability. In fact, the lower costs compared to the synthetic fibers allow their diffusion in emerging countries. In a first part the impact of constituents on the structural capacity of masonry elements strengthened with natural systems has been discussed. Important results have been provided in order to improve the knowledge and encourage the development of these systems in many engineering applications. Finally, the effects of retrofit systems on masonry walls under tsunami loads will be discussed in terms of critical inundation depth variations before and after the interventions.
Analysis of stress block parameters for high strength concrete
Authors: Singh Brijesh , Patel Vikas , Ohja P N , Arora V V 
Published: May 2021

In Indian Standard code IS: 456-2000 for concrete of grades higher than M55, the design parameters given may not be applicable as structural behaviour of concrete changes as strength of concrete increases. Different international standards give different stress block parameters which can be reduced to these two basic factors. In this paper, stress block parameters K (strength reduction factor) and k2 (factor for the depth of resultant compressive force) were calculated from experimental strain values considering the stress-strain curve as parabolic for lower grades and as linear for higher grades. Also, the method and approach for the calculation of stress block parameters have been worked out. The method so proposed is compared with the model proposed in European design standard EC: 02-2004 by transforming the European stress block parameters to the basic parameters used. Also, the effect of the shape of the stress-strain curve and value of ultimate strain in concrete on stress block parameters and moment capacity of the members was analyzed by working on the representative section. The method or approach so proposed will be useful to understand and compare flexural design philosophies used in different international standards by reducing the stress block parameters to two basic factors.
Effect of clay as deleterious material on properties of normal-strength concrete
Authors: Chaudhary Harish R. , Dauji Saha , Siddiqui Arham 
Published: May 2021

Sustainability concerns prompted use of crushed aggregates in concrete, wherein deleterious materials might get inadvertently included. Some deleterious materials are allowed up to limiting values by most standards, which, however, are silent about the quantification of their effects on properties of concrete – which would be site specific. For an important Indian infrastructure, this study quantifies effects of clay fines as deleterious material in concrete, on workability (slump) and strength (cube compression; split tensile; flexural tensile tests) around the limit (1% of fine aggregates by weight) stipulated by the Indian standard. The novelty of the study is that, contrary to the literature in this domain, the effects are studied without alteration of the mix proportions – a different practical scenario. The limit of clay fines in concrete allowed by Indian standard was found to be adequate considering strength parameters, but for maintaining target workability, the limit would be revised to 0.5% of the fine aggregates. Generally, the variations of concrete properties with the increasing clay fines were: (1) the workability and split tensile strength reduced monotonically, in non-linear fashion; (2) compressive strength (beyond 7 days) and the flexural tensile strength (modulus of rupture) reduced monotonically in linear manner.
AVALIAÇÃO DO PERFIL EPIDEMIOLÓGICO DOS CASOS DE DENGUE NO MUNICÍPIO DE PORTO NACIONAL, TOCANTINS.
Authors: Cardoso Lucena Letícia , Souto Alexandre Arguelio , Lucena Larissa Cardoso , Marques Tathiana Nascimento 
Published: May 2021

Introdução – A dengue é uma doença viral infecciosa, transmitida principalmente pelo mosquito Aedes aegypt e de grande incidência no Brasil. É uma enfermidade de grande potencial epidêmico, representando um grave problema de saúde pública. Objetivo – avaliar o perfil dos casos de dengue no município de Porto Nacional - TO no período de janeiro de 2010 a outubro de 2018. Metodologia – Este é um estudo descritivo, quantitativo e transversal realizado através da avaliação de dados do SINAN sobre a dengue no período de 2010-2018 e de levantamento bibliográfico em bases de dados eletrônicas. Resultados – Com a análise dos dados observou-se a notificação de 5.085 casos de dengue no período, a maioria no ano de 2010. A prevalência foi no sexo feminino (53,9%) e na faixa etária de 20-29 anos (22%), com maior ocorrência no período de janeiro a abril, época de índices pluviométricos mais altos, facilitando a procriação do vetor. Outrossim, as localidades com os maiores números de notificação são áreas mais abastadas e com menos condições sanitárias. Conclusão – Ainda há ocorrência de subnotificação, além de problemas nos serviços de saúde, sendo necessária adoção de medidas de prevenção e combate, e melhorias nos serviços de saúde.
Palavras-chave: Dengue; Arboviroses; Saúde pública; Epidemia.
ABSTRACT
Introduction – Dengue is an infectious viral disease, transmitted mainly by the Aedes aegypt mosquito and of great incidence in Brazil. It is a disease of great epidemic potential, representing a serious public health problem. Objective – To evaluate the profile of dengue cases in the municipality of Porto Nacional - TO from January 2010 to October 2018. Methodology – This is a descriptive, quantitative and cross - sectional study carried out through the evaluation of SINAN data on dengue in period of 2010-2018 and a bibliographic survey in electronic databases. Results – Data were analyzed in a study of 5,085 dengue cases in the period, most of them in 2010. The prevalence was in the female sex (53.9%) and in the age group of 20-29 years (22 %), with higher occurrence in the period from January to April, season of higher rainfall indexes, facilitating the procreation of the vector. In addition, the locations with the highest reporting numbers are more affluent areas with less sanitary conditions. Conclusion – There is still an underreporting, besides problems in the health services, being necessary to adopt measures of prevention and combat, and improvements in health services.
Keywords: Dengue; Arboviruses; Public health; Epidemic.
CARCINOMA ESOFÁGICO DE CÉLULAS ESCAMOSAS - RELATO DE CASO
Authors: Anjos Luana Silva e Silva dos , Akowanou Gboado Emmanuella Richenel Hermine , Isecke Nickolas Cezar , Medeiros Luiz Guilherme Pereira , Pedreira Raymundo do Espírito Santo 
Published: May 2021

A neoplasia de esôfago é relativamente rara e marcada por alta mortalidade. Com maior incidência em homens acima de 50 anos, está fortemente associada ao tabagismo e etilismo. Seu diagnóstico na maioria das vezes é tardio devido aos sintomas iniciais que são vagos podendo sugerir outas patologias do trato digestivo. Existem 20 tipos histológicos porem dois são mais importantes: o tipo epidermóide e o adenocarcinoma. O local mais acometido é o terço-médio do esôfago associado à doença do refluxo e esôfago de Barret. O prognóstico varia conforme o tipo histológico e o estágio do tumor. É necessária uma abordagem minuciosa dos pacientes da população de risco, mesmo que apresentem queixas esofágicas incipientes, para esta doença. Em razão disso, a descrição epidemiológica científica, fatores como idade, história familiar e fatores extrínsecos como álcool e tabagismo devem ser de alerta para pesquisa desta neoplasia para um diagnóstico e tratamento o mais precoce possível e aumento da sobrevida desses pacientes.
Palavras-chave: Neoplasias esofágicas; fatores de risco; diagnóstico precoce.
ABSTRACT
Esophageal neoplasia is relatively rare, with a high mortality. With greater incidence in men over 50 years old, associated with smoking and alcohol consumption. Its diagnosis is most often late due to initial symptoms that are vague and may suggest other pathologies of the digestive tract. There are 20 histological types, but two are more important: the carcinoma of scaly cells and adenocarcinoma. The most affected place is the middle third of the esophagus associated with reflux disease and Barrett's esophagus. The prognosis varies according to the histological type and tumor stage. A thorough approach is required for patients in the at-risk population, even if they have incipient esophageal complaints, for this disease. Therefore, the scientific epidemiological description, the factors like age, family history and extrinsic factors such as alcohol and tobacco should be alert to research of this neoplasm for a diagnosis and treatment as early as possible and increase survival of these patients.
Keywords: Esophageal Neoplasms; Risk factors; early diagnosis.
PENFIGÓIDE BOLHOSO, DESAFIO TERAPÊUTICO EM PACIENTE COM MÚLTIPLAS COMORBIDADES
Authors: Torga de Lima e Silva Camila , Costa Milena Katrini , Araújo Fellipe Magela de , Pugliesi Yasmin , Tavares Luciane Prado e Silva , Guedes Virgilio Ribeiro 
Published: May 2021

O Pênfigóide bolhoso (PB) é uma bulose autoimune, mais comum em idosos, caracterizada por bolhas subepidérmicas, tensas e grandes. Este trabalho apresenta uma paciente idosa, portadora de Diabetes melitus e Hipertensão arterial sistêmica, com queixa de bolhas difusas pelo corpo. Ao exame laboratorial demonstrou eosinofilia de 742/mm3 e aumento de IgE equivalente a 469 kU/L; anatomopatológico com bolha subepidérmica e infiltrado inflamatório rico em eosinófilos; e imunofluorescência com imunodepósitos na junção dermo-epidérmica constituídos por IgG e C3. Mediante esses achados, paciente recebeu diagnóstico de PB. Devido as comorbidades apresentadas, a corticoterapia não foi a primeira opção, a tetraciclina apresentou falha terapêutica e a dapsona 100mg/dia, por 6 meses, foi resolutiva. Conclui-se que cada paciente deve ter seu manejo individualizado para melhores resultados.
Palavras-chave: penfigóide bolhoso; bulose; doença autoimune.
ABSTRACT
Bullous pemphigoid (BP) is an autoimmune bulge, more common in the elderly, characterized by subepidermal, tense and large blisters. This study presents an elderly patient with diabetes mellitus and systemic arterial hypertension, with diffuse blisters on the body. Laboratory examination showed eosinophilia of 742/mm3 and an increase of IgE equivalent to 469 kU/L; anatomopathological with subepidermal bubble and inflammatory infiltrate rich in eosinophils; and immunofluorescence with immunodeposits at the dermo-epidermal junction consisting of IgG and C3. Based on these findings, the patient was diagnosed with BP. Due to the comorbidities of the patient, corticotherapy was not the first option, tetracycline presented therapeutic failure, and dapsone 100mg / day for 6 months was resolution. It is concluded that each patient should have their individualized management for best results.
Keywords: Ashy pemphigoid; bulge; autoimune disease.
HEMANGIOMA TESTICULAR CAVERNOSO
Authors: Albuquerque Ingrid Lima , Da Costa Benito Júnior Santos , Costa Marcus Vinícius Silva 
Published: May 2021

Hemangioma testicular é extremamente raro e ocorre principalmente em pacientes com menos de vinte anos de idade. Devido à semelhança com lesões malignas, a orquiectomia radical geralmente é o tratamento estabelecido. No presente relato de caso, apresentamos um paciente com quinze anos de idade, apresentando tumoração testicular unilateral, com contornos irregulares, alto fluxo na ultrassonografia com Doppler e marcadores tumorais negativos. Submetido a orquiectomia radical, sendo evidenciado hemangioma testicular cavernoso, um tumor raro, de evolução benigna, cujo diagnóstico histopatológico é considerado o padrão ouro. Com base neste relato, foi feita uma revisão de literatura com os principais aspectos sobre esse diagnóstico.
Palavras chave: hemangioma testicular; neoplasia testicular benigna; orquiectomia.
Tratamento não-operatório de diverticulite complicada com pneumoperitônio: um relato de caso e revisão da literatura.
Authors: Barbosa Junior Antonio Rozeni Gomes , Brito Maria Luiza Silva , Araújo Luiz Henrique Moraes Sampaio , Bitencourt Evandro Leite , Sousa Bruno de Oliveira Araújo 
Published: May 2021

A doença diverticular dos cólons é uma patologia frequente no nosso meio, mais comumente encontrada nos prontos-socorros em sua forma complicada de diverticulite aguda. Há algum tempo o tratamento conservador vem ganhando espaço na condução desta complicação, inclusive nas formas avançadas. Este artigo relata um caso de uma paciente de 47 anos, apresentando quadro de diverticulite aguda complicada com pneumoperitôneo, onde foi realizado tratamento conservador com sucesso terapêutico. Apesar de existir tratamento menos agressivo do que a cirurgia aberta, como a videolaparoscopia e a punção por agulha, a abordagem cirúrgica versus tratamento conservador ainda é assunto controverso dentro das discussões clínicas. Estudos recentes vem corroborando cada vez mais com o tratamento conservador e resseção cirúrgica eletiva.
ASPERGILLUS FUNGUS BALL: HEMOPTYSIS IN PATIENT WITH PRIOR HISTORY OF CURED PULMONARY TUBERCULOSIS
Authors: Castro Ana Flávia de Oliveira , Dos Santos Júnior José Manoel , Rocha Cardoso Káritas 
Published: May 2021

ABSTRACT
Lung aspergilloma consists of a fungal mass composed predominantly by Aspergillus fumigatus formed within a prior lung cavity, in greater numbers in healed tuberculosis caverns. Clinically, it is marked by patients in their fourth or fifth decade of life presenting most commonly repeating episodes of small volume of hemoptysis. The present report describes the case of a 66-year-old male patient, admitted with hemoptysis of large amount associated with dyspnea, and past pathological history of hemoptysis episodes more than 24 years after diagnosis and treatment of tuberculosis in 1994. Data were obtained through analysis the patient’s medical records and laboratory and imaging exams performed on the patient during the hospitalization period. This paper highlights a relevant cause of hemoptysis in patients with previous history of tuberculosis and clarifies the clinical and imaging investigation for timely diagnosis and appropriate therapy in such cases.