bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacological Characterization of Toludesvenlafaxine as a Triple Reuptake Inhibitor
Authors: Zhu Haibo , Wang Wenyan , Sha Chunjie , Guo Wei , Li Chunmei , Zhao Fengjuan , Wang Hongbo , Jiang Wanglin , Tian Jingwei 
Published: September 2021

Toludesvenlafaxine hydrochloride dihydrate is a novel chemical entity and a potential triple monoamine reuptake inhibitor. This study characterized the in vitro triple reuptake inhibition activity, antidepressant-like activity in animals, and pharmacokinetic profiles in rats of toludesvenlafaxine. Binding affinity was determined using human serotonin transporter (SERT) protein, norepinephrine transporter (NET) protein and dopamine transporter (DAT) protein, and the reuptake inhibition was determined using Chinese hamster ovary cells expressing human SERT, NET and DAT. The antidepressant-like activity was examined in rat chronic unpredictable mild stress model and olfactory bulbectomized model. In rats, the tissue distribution and pharmacokinetic parameters were determined. Toludesvenlafaxine had high binding affinity on SERT, NET and DAT, and significantly inhibited the reuptake of serotonin (IC50 = 31.4 ± 0.4 nM), norepinephrine (IC50 = 586.7 ± 83.6 nM) and dopamine (IC50 = 733.2 ± 10.3 nM) in vitro. Toludesvenlafaxine demonstrated significant antidepressant-like effects in rat models at 8–16 mg/kg. In addition, toludesvenlafaxine significantly reduced serum corticosterone and significantly increased testosterone levels in rats. Toludesvenlafaxine was quickly absorbed and converted to O-desvenlafaxine (ODV) after oral administration, both of which were selectively distributed into the hypothalamus with high concentration. Plasma ODV exposure was proportionally related to the doses after oral dosing. These results suggest that toludesvenlafaxine is a triple reuptake inhibitor with relatively fast-acting antidepressant-like activity and good therapeutic profile including improvement of anhedonia and sexual function.
A Structural Equation Model of Self-Regulation and Healthy Habits as an Individual Protective Tool in the Context of Epidemics–Evidence From COVID-19
Authors: Sousa Sónia S. , Ferreira Marisa M. , Cruz Sara , Sampaio Adriana , Silva-Fernandes Anabela 
Published: September 2021

Objective: The present study aims to explore the mediation role of self-regulation on health-related behaviors adoption or maintenance, mental health, and well-being during the COVID-19 confinement in a sample of adults in Portugal.Design: One-hundred fifty individuals (118 females, 32 males; Mage = 33.57 year; SD = 12.71) filled an online survey to assess self-regulation, healthy behaviors, mental health, and well-being perception, during the early months of the pandemic (June–August, 2020).Main Outcome Measures: Self-regulation capacity, adoption or maintenance of healthy habits, mental health, including stress management, and the perception of one’s well-being were evaluated using a structural equation model (SEM).Results: Self-regulation had direct effects on healthy habits and mental health and indirect effects on well-being and mental health mediated by healthy habits. In specific, a positive direct effect on healthy habits (β = 0.497, p &lt; 0.001) and a negative direct effect on mental health (β = −0.428, p &lt; 0.001); and a positive indirect effect on well-being perception, mediated by healthy behaviors and mental health (β = 0.253, p = 0.003), and a negative indirect effect on mental health, mediated by healthy habits (β = −0.208, p = 0.003). Additionally, healthy habits exerted direct effects on well-being perception and mental health. A positive direct effect on well-being perception (β = 0.254, p = 0.012), and a negative direct effect on mental health (β = −0.418, p &lt; 0.001) were further observed. No direct effect of mental health was observed in well-being perception (β = −0.199, p = 0.068). Finally, a negative correlation was observed between self-regulation and weeks of confinement (r = −0.208, p = 0.021).Conclusion: Self-regulation seems to be a good indicator of adopting a healthy lifestyle and better mental health and well-being in the context of the COVID-19 pandemic. Future preventive actions and interventions to build long-term global preparedness for future health emergencies, such as COVID-19, should explore the importance of self-regulation as an important individual and collective protective factor.
Impact of the COVID-19 Pandemic on Child and Adolescent Mental Health Policy and Practice Implementation
Authors: Palinkas Lawrence A. , De Leon Jessenia , Salinas Erika , Chu Sonali , Hunter Katharine , Marshall Timothy M. , Tadehara Eric , Strnad Christopher M. , Purtle Jonathan , Horwitz Sarah McCue , McKay Mary M. , Hoagwood Kimberly E. 
Published: September 2021

Background: The impact of the 2019 coronavirus pandemic on the mental health of millions worldwide has been well documented, but its impact on prevention and treatment of mental and behavioral health conditions is less clear. The COVID-19 pandemic also created numerous challenges and opportunities to implement health care policies and programs under conditions that are fundamentally different from what has been considered to be usual care. Methods: We conducted a qualitative study to determine the impact of the COVID-19 pandemic on implementation of evidence-based policy and practice by State Mental Health Authorities (SMHA) for prevention and treatment of mental health problems in children and adolescents. Semi-structured interviews were conducted with 29 SMHA representatives of 21 randomly selected states stratified by coronavirus positivity rate and rate of unmet services need. Data analysis with SMHA stakeholders used procedures embedded in the Rapid Assessment Procedure—Informed Community Ethnography methodology. Results: The need for services increased during the pandemic due primarily to family stress and separation from peers. States reporting an increase in demand had high coronavirus positivity and high unmet services need. The greatest impacts were reduced out-of-home services and increased use of telehealth. Barriers to telehealth services included limited access to internet and technology, family preference for face-to-face services, lack of privacy, difficulty using with young children and youth in need of substance use treatment, finding a Health Insurance Portability and Accountability Act (HIPAA)-compliant platform, training providers and clients, and reimbursement challenges. Policy changes to enable reimbursement, internet access, training, and provider licensing resulted in substantially fewer appointment cancellations or no-shows, greater family engagement, reduction in travel time, increased access for people living in remote locations, and increased provider communication and collaboration. States with high rates of coronavirus positivity and high rates of unmet need were most likely to continue use of telehealth post-pandemic. Despite these challenges, states reported successful implementation of policies designed to facilitate virtual services delivery with likely long-term changes in practice. Conclusions: Policy implementation during the pandemic provided important lessons for planning and preparedness for future public health emergencies. Successful policy implementation requires ongoing collaboration among policy makers and with providers.
Arteriovenous Fistula Nonmaturation: What’s the Immune System Got to Do with It?
Authors: Farrington Crystal A. , Cutter Gary , Allon Michael 
Published: September 2021

Key Points

Arteriovenous fistula (AVF) nonmaturation is a persistent problem, and there are some notable disparities in AVF maturation outcomes by sex and race.Panel reactive antibodies (PRA) are markers of immune system reactivity that tend to be higher among female and Black patients, and are associated with greater cardiovascular mortality outside the transplant setting.On multivariable analysis, class II PRA were independently associated with greater rates of AVF nonmaturation in this study population, suggesting a possible role for the adaptive immune system in AVF maturation outcomes.

Background
Arteriovenous fistula (AVF) nonmaturation is a persistent problem, particularly among female and Black patients. Increasingly, the immune system has been recognized as an important contributor to vascular disease, but few studies have examined immune factors relative to AVF maturation outcomes. This study evaluated the association of serum panel reactive antibodies (PRA), a measure of immune system reactivity assessed in patients undergoing kidney transplant evaluation, with AVF nonmaturation.

Methods
We identified 132 patients at our institution who underwent surgical AVF placement between 2010–2019 and had PRA testing within 1 year of AVF creation. Multivariable logistic regression was used to determine the association of patient demographic and clinical factors, class I and class II PRA levels, and preoperative arterial and venous diameters with AVF maturation outcomes.

Results
AVF nonmaturation was more likely in females than males (44% versus 20%, P=0.003) and in Black than white patients (40% versus 13%, P=0.001). Class II PRA was higher in females than males (12%±23% versus 4%±13%, P=0.02). In the multivariable model, AVF nonmaturation was associated with class II PRA (adjusted odds ratio [aOR], 1.34 per 10% increase; 95% confidence interval [95% CI], 1.04 to 1.82, P=0.02) and Black race (aOR, 3.34; 95% CI, 1.02 to 10.89, P=0.03), but not with patient sex or preoperative arterial or venous diameters.

Conclusions
The association of elevated class II PRA with AVF nonmaturation suggests the immune system may play a role in AVF maturation outcomes, especially among female patients.
Approaches Towards Tannery Modernization and Up-Gradation: Leather Industry 4.0
Authors: Sivakumar Venkatasubramanian 
Published: September 2021

Analysis of various approaches for tannery modernization and up-gradation as leather industry 4.0 need to be analyzed keeping in view of significant advancements made in different disciplines of relevance to leather sector. Holistic views and plans for cleaner image with better environmental aspects are essential for the sustainable growth of the leather sector. in this paper, various plans and strategies for the next phase of tannery modernization denoted as TAN MOD 4.0 have been presented with the main objectives of near zero discharge of chemicals, waste minimization, value addition, productivity enhancement and safe & healthy environment in tannery. Different components such as basic up-gradation concepts, modern leather processing techniques and engineering inputs for leather sector such as process control systems, necessary automation tools and Internet of Things (IoT) are discussed.
Polyurethane Electrospun Fiber Biomimetics Membrane for Constructing the Structure of Grain Layer with Good Breathability for Cattle Split Leather
Authors: Chen Nan , Li Yanchun , Qu Jianbo , Wang Jian-Yong 
Published: September 2021

The traditional thick coating on split leather does not have the ability to breathe like full grain leather. The air and water vapor permeabilities of full grain leather are well known properties due to its fiber woven structure. Simulating the fiber morphology and weaving structure of the dermis or grain layer is very important to construct a top surface layer for split leather. In this paper, a PU (polyurethane) foam layer is put first on the split to enhance the adhesion of a second application of a superfine fibrous PU resin. This foam uses well-known waterborne polyurethane foaming technology. This dried foam has good breathability because of high porosity. A superfine fiber membrane is next put atop of the foam layer by using an electro-spun polyurethane resin. This second resin imitates collagen fibers in the network structure of the leathers’ grain layer. Thus, this resultant electrospun fiber biomimetics membrane simulated the grain layer of natural leather. SEM showed the morphology and structure of this electrospun fiber biomimetic membrane to be like that of the grain layer of natural leather. The porosity and apparent density were basically the same as the grain of leather, which were 63.65% and 583.878 kg/m3 respectively. The air and water vapor permeability of the biomimetics membrane were also as high as 2250 mL·cm-2·h-1 and 8753.02 μg·cm-2·h-1 respectively. Therefore, the biomimetics membrane largely restored the ability to breathe of split leather. Thus, this method simulates the performance and structure of full grain leather and is a novel method for industrial production
Habilidades motrices en la infancia y su desarrollo desde una educación física animada
Authors: Gil Madrona Pedro , Contreras Jordán Onofre Ricardo , Gómez Barreto Isabel 
Published: September 2021

En la etapa de educación infantil los niños hallan en su cuerpo y en el movimiento las principales vías para entrar en contacto con la realidad que los envuelve y, de esta manera, adquirir los primeros conocimientos acerca del mundo en el que están creciendo y desarrollándose. Sin duda, el progresivo descubrimiento del propio cuerpo como fuente de sensaciones, la exploración de las posibilidades de acción y funciones corporales, constituirán experiencias necesarias sobre las que se irá construyendo el pensamiento infantil. Asimismo, las relaciones afectivas establecidas en situaciones de actividad motriz, y en particular mediante el juego, serán fundamentales para el crecimiento emocional. En este sentido, en el presente artículo nos ocuparemos de justificar la necesaria presencia de la educación física y de presentar un diseño de intervención en la praxis en esta etapa educativa.Por otra parte, es precisamente a esta asignatura, y para la etapa que nos ocupa, que le corresponde la tarea de dar respuestas a las cuestiones planteadas, y a otras tales como el excesivo sedentarismo o la obesidad infantil. Para ello es necesario que los maestros y educadores de este nivel educativo se cuestionen, de forma responsable, las intenciones y las formas de intervención didáctica en el ámbito motor. Es por ello que en este artículo recogemos conceptos y supuestos en torno al desarrollo motor, los contenidos motrices, la expresión corporal, el juego motor y el planteamiento metodológico y programador de la motricidad en la etapa de educación infantil.
La netnografía: un método de investigación en Internet
Authors: Turpo Gebera Osbaldo Washington 
Published: September 2021

La netnografía se presenta como un nuevo método investigativo para indagar sobre lo que sucede en las comunidades virtuales, mas propiamente de lo que acontece en Internet. El método deviene de la aplicación de la etnografía al estudio del ciberespacio. Su pretensión transita por erigirse como ciencia de lo que ocurre en la red de redes, esta pretensión, reclamada por toda disciplina emergente, aún es difusa; se presenta más como una técnica de investigación de las vivencias en los espacios virtuales.
Sus orígenes se sitúan en los Estados Unidos, su aplicación actual más evidente es la expresada por el marketing, en los estudios de mercado. Considerando para ello, unas determinadas fases que reúnen lo artificial, proporcionado por los ordenadores con el trabajo natural, de los seres humanos, a fin de determinar las decisiones más apropiadas para brindar óptimamente el consumo de un producto o servicio.
A Educação em tempos de globalização. Modernização e hibridismo nas políticas educativas em Portugal
Authors: Teodoro António , Aníbal Graça 
Published: September 2021

O artigo pretende apresentar uma reflexão sobre as políticas educativas e os discursos que as justificam, num tempo de procura de integração de Portugal no espaço europeu após a década de sessenta e especialmente no quadro democrático do pós-revolucionário de 1974, identificando uma relevância gradual no entendimento do papel primordial do sistema educativo no desenvolvimento económico. Defende que, especialmente a partir da década de 80, e a partir de uma análise empírica das palavras-chave, revela-se um carácter híbrido nos discursos dos responsáveis políticos que associa uma orientação construtivista numa perspectiva crítica com a apologia da eficácia do sistema, entendida como necessária à produtividade económica.
Considera-se a importância do contexto nacional e do sentido que as suas características conferem ao modelo globalizado de modernização para explicar por que a tendência homogeneizante da regulação internacional é mitigada por preocupações de cariz emancipatório.
Después de la tormenta neoliberal: La política educativa latinoamericana entre la crítica y la utopía
Authors: Torres Carlos Alberto 
Published: September 2021

Este artículo, que tiene como marco referencial la extensión de oportunidades educativas a niños, a jóvenes e incluso a adultos de todos los sectores sociales en América Latina que marcó el siglo xx, muestra cómo el ideario de la Ilustración benefició la ampliación de los servicios educativos en pre-escolar, primaria, secundaria y universidad, generando una expansión educativa de envergadura. Unidad en la diver­sidad de experiencias educativas en la región puede ser la divisa de esta conversación sobre grandezas y miserias en la educación latinoamericana en el siglo pasado. Haciendo un balance de su expansión y crisis, se sintetizan aquí algunas de las grandes propuestas neoliberales en la educación, especialmente la agenda de la privatización que contraviene profundamente los principios de extensión de oportunidades educativas, calidad de la educación, igualdad y acceso predicados por los gobiernos liberales de la región. Con razón el sociólogo y educador argentino Daniel Filmus, quien fuera ministro de Educación, en los comentarios finales de su artículo titulado «Liberales eran los de antes» (Filmus, 1996), ofrece algunas perspectivas críticas sobre las opciones utópicas de la educación a partir de la constatación de que hay una serie de hechos interrelacionados: a) una crisis endémica de los sistemas que se refleja en una dislocación real y simbólica entre los discursos de los maestros y los alumnos; b) una dislocación entre los discursos de las nuevas generaciones y los adultos, y c) una fuerte crisis de legitimidad de los sistemas educativos en términos de su efectividad.
Se concluye que la lucha por la educación no es una mera actividad tecnocrática, implementada en los escritorios burocráticos o negociada en los salones escolares, claustros ministeriales y traspatios sindicales. Tampoco es, simplemente, una lucha por mejorar las oportunidades educativas de los individuos, sino que la lucha por la educación es una cuestión de Estado y una lucha por la defensa del pacto democrático.
Design Design of Information System Monitoring Complaints Targeting COVID-19 Vaccination for the General Public Based on the Web (Case Study of Bandung Health Office)
Authors: Aldiansyah Reihan Fazri , Ramadhan Syams Syair , Arifin Jaenal , Agustin Cahyadi 
Published: September 2021

Bandung Health Office as a Health Agency that always provides quality services is currently focused on handling pandemics, especially in the implementation of vaccination programs as a strategy to combat the COVID-19 outbreak. Therefore, monitoring of complaints experienced by the community after vaccination is required. The problem experienced today is the unavailability of containers to accommodate and manage data on COVID-19 vaccination complaints using the information system. The purpose of this research is to design a website-based information system that supports the process of monitoring and handling COVID-19 vaccination complaints in the Bandung Health Office by presenting informative and transparent data so as to facilitate the public in reporting and obtaining complaint information easily. The system development method uses waterfall model, while the system functional design method uses object-oriented modeling approach with Unified Modelling Language (UML). Black box test results obtained a 100 percentage of system functionality success. Evaluation test results with System Usability Scale (SUS) questionnaire obtained the final test score of 77.6 with Acceptable category and B Grade Scale. So based on the test results, the system can run easily according to the needs of the user. This research resulted in a web-based information system that makes it easier for health workers to efficiently manage COVID-19 vaccination complaint reporting data.
COMPOSITIONAL PROCESS OF MOBILE APPLICATION DEVELOPMENT BASED ON HETEROGENEOUS SOFTWARE OBJECTS
Authors: Дорошенко Ю.Н. , Кравец О.Я. , Акинина Ю.С. 
Published: September 2021

Несмотря на множество доступных мобильных приложений с различными формами реализации (например, компонент, услуга или приложение), потребности пользователя отличаются от одного к другому. Кроме того, мобильные устройства характеризуются разнородными программными и аппаратными конфигурациями. Таким образом, важной проблемой при разработке мобильных приложений является их развертывание на доступных разнородных устройствах. Для решения этих проблем необходим процесс композиции, позволяющий повторно использовать существующие разнородные объекты для разработки мобильных приложений в соответствии с требованиями пользователя, и чтобы поведение желаемых приложений можно было настраивать в соответствии с их различной контекстной информацией. В статье эта проблема решается на основе процесса создания мобильных приложений с учетом контекста на основе существующих гетерогенных программных объектов.
Despite the many mobile applications available with different forms of implementation (for example, a component, service or application), the user's needs differ from one to another. In addition, mobile devices are characterized by heterogeneous software and hardware configurations. Thus, an important problem in the development of mobile applications is their deployment on available heterogeneous devices. To solve these problems, we need a composition process that allows us to reuse existing heterogeneous objects for developing mobile applications in accordance with the user's requirements, and so that the behavior of the desired applications can be customized according to their different contextual information. In the article, this problem is solved on the basis of the process of creating mobile applications taking into account the context on the basis of existing heterogeneous program objects.
ANALYSIS OF THE AGRICULTURAL VEHICLE ROBOTIC SYSTEM EFFECTIVENESS
Authors: Яковлева А.Е. , Сусарев С.В. , Орлов С.П. 
Published: September 2021

В статье предлагается методика оценки комплекса параметров, характеризующих функционирование роботизированной системы сельскохозяйственных автомобилей. Для сравнения роботизированных автомобилей различных моделей предложено использовать метод анализа среды функционирования. В результате решения задачи линейного программирования с интегральным критерием эффективности построены границы эффективности в пространстве входных и выходных параметров оцениваемых автомобилей. Приведены результаты экспериментального исследования, позволяющие получить целевые изменения параметров транспортных средств.
The article proposes a methodology for assessing a set of parameters that characterize the functioning of an agricultural robotic vehicle system. It is proposed to use the Data Envelopment Analysis method to compare robotic vehicles of various models. The efficiency frontiers in the evaluated cars' input and output parameter space are constructed by solving a linear programming problem with an integral criterion of efficiency. The experimental results are presented to obtain target changes in the vehicle parameters.