bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interleukin-10-592 polymorphism: impact on relapse and survival after allogeneic hematopoietic stem cell transplantation in children with hematological malignancies
Authors: Schwenk Laura , Wittig Susan , Gruhn Bernd 
Published: June 2021

AbstractPurposeInterleukin-10 (IL-10) potentially can promote the development of alloimmunity. The aim of this study was to investigate if the IL-10-592 CC genotype in the donor reduces the risk of relapse after hematopoietic stem cell transplantation (HSCT) and if that has an impact on event-free survival (EFS) and overall survival (OS).MethodsA cohort of 211 children with acute lymphoblastic leukemia (n = 99), acute myeloid leukemia (n = 69), myelodysplastic syndrome (n = 31) or chronic myeloid leukemia (n = 12) who underwent hematopoietic stem cell transplantation (HSCT) in a single center and their respective donors were genotyped of IL-10 gene for rs1800872 using TaqMan real-time polymerase chain reaction.ResultsThe IL-10-592 CC genotype was detected in 107 of the 211 donors (50.7%) and in 106 of the 211 patients (50.2%). Genotype AC was found in 95 donors (45.0%) and in 90 patients (42.7%). Nine donors (4.3%) and 15 patients (7.1%) were homozygous for AA. Ultimately, we observed a significantly reduced incidence of relapse rate (RR) in patients who were transplanted from a donor with the IL-10-592 CC genotype (19% versus 43% (AC) versus 49% (AA);P = 0.0007). In addition, a significant increase of EFS (P = 0.004) and OS (P = 0.006) was detected if the IL-10-592 CC genotype is present in the donor. The occurrence of the IL-10-592 CC genotype, in either donors or recipients, had no significant impact on acute and chronic graft-versus-host disease. In addition, the IL-10-592 genotype of the recipients was not relevant for the RR (P = 0.47434), the EFS (P = 0.840), and the OS (P = 0.535).ConclusionThe IL-10-592 CC genotype in the donor was associated with a significant decrease of RR which led to a significant increase of EFS and OS after HSCT. This is the first study to describe an association of the IL-10 gene polymorphism with RR, EFS, and OS after HSCT. Selecting a donor with the IL-10-592 CC genotype could be a useful therapeutic strategy for improving the outcome after allogeneic HSCT.
Ecological traps: evidence of a fitness cost in a cavity-nesting bird
Authors: Krams Ronalds , Krama Tatjana , Brūmelis Guntis , Elferts Didzis , Strode Linda , Dauškane Iluta , Luoto Severi , Šmits Agnis , Krams Indrikis A. 
Published: June 2021

AbstractHabitat quality has direct effects on the evolutionary fitness of breeding organisms, which is why it is believed that animals tend to have an evolved preference for the best possible habitats. However, some animals may mistakenly choose to reproduce in habitats that decrease their fitness, resulting in ‘ecological traps’. In this study, we tested whether great tits (Parus major) attracted to areas affected by outbreaks of the great web-spinning sawfly (Acantholyda posticalis) had fitness detriments characteristic of ecological traps. Sawfly larvae consume pine needles, which decreases resource availability for birds co-habiting the forest. Using artificial nesting sites, we found that great tits inhabiting areas of sawfly outbreaks had similar clutch sizes as tits breeding in healthy forest patches; however, the fledgling number was significantly lower, and fledgling condition was worse in the damaged forests. While moth larvae are the most important food for bird nestlings, the forest patches damaged by sawflies had lower larval biomass. Although most ecological traps occur in environments altered by humans, this study shows that pest insects can lower habitat quality, forming ecological traps. Our results indicate that attracting cavity-nesting birds should be done with caution because it may negatively impact birds’ nutritional status and reproductive fitness.
Linear or circular: Anastomotic ulcer after gastric bypass surgery
Authors: Schäfer Aline , Gehwolf Philipp , Kienzl-Wagner Katrin , Cakar-Beck Fergül , Wykypiel Heinz 
Published: June 2021

Abstract
Background
After laparoscopic Gastric Bypass Procedure (GBP), anastomotic ulcers (AU) at the gastrojejunostomy (GJ) occur in up to 16% of the patients. Surgical techniques seem to influence the development of AU, but this is still a matter of discussion. This study aims to compare the incidence of AU in circular-stapled (CS) versus linear-stapled (LS) gastrojejunostomy.

Methods
Single-centre retrospective analysis of 241 (m 77 /f 164) consecutive patients (126 CS, 115 LS) with primary or revisional GBP including Roux-Y-Gastric Bypass (RYGB) and One-Anastomosis Gastric Bypass (OAGB) between 01/2014 and 01/2018. Follow-up with oesophagogastroduodenoscopy was only performed in symptomatic patients. Age, body mass index (BMI), comorbidities, smoking and medication were analyzed in both groups. The data are reported as total numbers (%) and mean ± standard deviation.

Results
AU occurred significantly more often in the CS group than in the LS group (p = 0.0034). Moreover, refractory AU and the need for revisional surgery were higher in the CS group. Smoking correlates significantly with the development of AU, whereas other risk factors had no impact on its incidence.

Conclusion
Linear-stapled gastrojejunostomy with a long and narrow pouch should be the preferable procedure for reducing AU development risk. Smoking cessation minimizes the risk for AU and is a necessary part of the treatment.
A simulator for both manual and powered wheelchairs in immersive virtual reality CAVE
Authors: Genova C. , Biffi E. , Arlati S. , Redaelli D. F. , Prini A. , Malosio M. , Corbetta C. , Davalli A. , Sacco M. , Reni G. 
Published: June 2021

AbstractA large number of people in the world need to use a wheelchair because of different disabilities. Driving a wheelchair requires complex physical and cognitive abilities which need to be trained. Virtual training helps users acquire driving skills in a safe environment. The aim of this paper is to describe and technically validate simulation models for both manual (MW) and powered wheelchairs (PW) based on immersive virtual reality CAVE (VR). As VR system, the Gait Real-time Analysis Interactive Lab (GRAIL) was used, a CAVE equipped with a motion platform with two degrees of freedom and an optoelectronic motion capture system. A real wheelchair was positioned onto the motion platform with rear wheels free to turn in MW modality, and a commercial joystick was installed on an armrest to simulate the PW modality. Passive markers were used to track the wheel rotation, the joystick and the user hand motion. Custom D-flow applications were developed to manage virtual scene response to user actions. Overground tests, based on single wheel rotation, were performed to verify the simulation model reliability. Quantitative results demonstrated that the MW simulator kinematics was consistent with a real wheelchair overground in the absence of wheel slip and inertia (median error for MW 0.40 °, no systematic bias p = 0.943, high correlation rho > 0.999, p < 0.01). The proposed solution is flexible and adaptable to different wheelchairs, joysticks and optoelectronic systems. The main limitation is the absence of force feedback. Nevertheless, it is a reliable prototype that can be used to validate new virtual scenarios as well as for wheelchair training. The next steps include the system validation with real end users and assessment of the simulator effectiveness as a training tool.
Silvicultural prescriptions for mixed-species forest stands. A European review and perspective
Authors: Pretzsch Hans , Poschenrieder Werner , Uhl Enno , Brazaitis Gediminas , Makrickiene Ekaterina , Calama Rafael 
Published: June 2021

AbstractCompared with far-developed measures and methods for mono-specific forest stands, the silvicultural prescriptions for mixed-species stands are at their early beginning. However, they are essential for the well-conceived establishment, design, and control of mixed-species stands, currently promoted in many countries worldwide. Here, we review the state of the art and we further develop silvicultural prescriptions for mixed-species stands for steering of experiments, stand modeling, and silviculture. We review which aspects of tree species mixing are most relevant for management goal achievement. We found the maintenance of species diversity and structural heterogeneity for ecological purpose, stabilizing productivity, and social-economic performance as main objectives. We give an overview of quantitatively formulated silvicultural prescriptions for steering mixed-species stands for forest practice, long-term experiments, forest stand models. Compared with the sophisticated guidelines for mono-specific stands, prescriptions for mixed stand are often mainly qualitative and vague. Then, we introduce methodological approaches in development for steering mixture: measures for spatial and temporal separation, species-specific growing space requirements for crop trees, coefficients for equivalence and density modification, and basic relationships for steering tree number and area-based mixing proportions. Finally, we draw conclusions for further development of methodological approaches for silvicultural steering of experiments, implementation in stand simulators, and for silvicultural operations. We see the need for improving the quantitative spatially explicit rules based at tree or cohort level, for substantiating the knowledge on species-specific allometry, growing area, tree-to-tree distances, and position-dependent competition indices for steering tree removal. We discuss the prospects and limitations of establishing silvicultural prescriptions for mixed-species stands that inevitably will be more complicated than those for mono-specific stands, and we draw conclusions for next steps in science and practice.
On the Sensitivity Analysis of Porous Finite Element Models for Cerebral Perfusion Estimation
Authors: Józsa T. I. , Padmos R. M. , El-Bouri W. K. , Hoekstra A. G. , Payne S. J. 
Published: June 2021

AbstractComputational physiological models are promising tools to enhance the design of clinical trials and to assist in decision making. Organ-scale haemodynamic models are gaining popularity to evaluate perfusion in a virtual environment both in healthy and diseased patients. Recently, the principles of verification, validation, and uncertainty quantification of such physiological models have been laid down to ensure safe applications of engineering software in the medical device industry. The present study sets out to establish guidelines for the usage of a three-dimensional steady state porous cerebral perfusion model of the human brain following principles detailed in the verification and validation (V&V 40) standard of the American Society of Mechanical Engineers. The model relies on the finite element method and has been developed specifically to estimate how brain perfusion is altered in ischaemic stroke patients before, during, and after treatments. Simulations are compared with exact analytical solutions and a thorough sensitivity analysis is presented covering every numerical and physiological model parameter. The results suggest that such porous models can approximate blood pressure and perfusion distributions reliably even on a coarse grid with first order elements. On the other hand, higher order elements are essential to mitigate errors in volumetric blood flow rate estimation through cortical surface regions. Matching the volumetric flow rate corresponding to major cerebral arteries is identified as a validation milestone. It is found that inlet velocity boundary conditions are hard to obtain and that constant pressure inlet boundary conditions are feasible alternatives. A one-dimensional model is presented which can serve as a computationally inexpensive replacement of the three-dimensional brain model to ease parameter optimisation, sensitivity analyses and uncertainty quantification. The findings of the present study can be generalised to organ-scale porous perfusion models. The results increase the applicability of computational tools regarding treatment development for stroke and other cerebrovascular conditions.
How Do Trees Grow in Girth? Controversy on the Role of Cellular Events in the Vascular Cambium
Authors: Wilczek-Ponce Anna , Włoch Wiesław , Iqbal Muhammad 
Published: June 2021

AbstractRadial growth has long been a subject of interest in tree biology research. Recent studies have brought a significant change in the understanding of some basic processes characteristic to the vascular cambium, a meristem that produces secondary vascular tissues (phloem and xylem) in woody plants. A new hypothesis regarding the mechanism of intrusive growth of the cambial initials, which has been ratified by studies of the arrangement of cambial cells, negates the influence of this apical cell growth on the expansion of the cambial circumference. Instead, it suggests that the tip of the elongating cambial initial intrudes between the tangential (periclinal) walls, rather than the radial (anticlinal) walls, of the initial(s) and its(their) derivative(s) lying ahead of the elongating cell tip. The new concept also explains the hitherto obscure mechanism of the cell event called ‘elimination of initials’. This article evaluates these new concepts of the cambial cell dynamics and offers a new interpretation for some curious events occurring in the cambial meristem in relation to the radial growth in woody plants.
The Structure of the Sarvadarśanasaṃgraha
Authors: Bronkhorst Johannes 
Published: June 2021

AbstractThis article shows in detail that the widely held view according to which the Sarvadarśanasaṃgraha has a hierarchical structure is mistaken. It further argues that at least some parts of the texts were independent essays before being incorporated into the Sarvadarśanasaṃgraha.
$$L^2$$-Betti numbers arising from the lamplighter group
Authors: Ara Pere , Claramunt Joan 
Published: June 2021

AbstractWe apply a construction developed in a previous paper by the authors in order to obtain a formula which enables us to compute $$\ell ^2$$

ℓ
2

-Betti numbers coming from a family of group algebras representable as crossed product algebras. As an application, we obtain a whole family of irrational $$\ell ^2$$

ℓ
2

-Betti numbers arising from the lamplighter group algebra $${\mathbb Q}[{\mathbb Z}_2 \wr {\mathbb Z}]$$

Q
[

Z
2

≀
Z
]

. This procedure is constructive, in the sense that one has an explicit description of the elements realizing such irrational numbers. This extends the work made by Grabowski, who first computed irrational $$\ell ^2$$

ℓ
2

-Betti numbers from the algebras $${\mathbb Q}[{\mathbb Z}_n \wr {\mathbb Z}]$$

Q
[

Z
n

≀
Z
]

, where $$n \ge 2$$

n
≥
2

is a natural number. We also apply the techniques developed to the generalized odometer algebra $${\mathcal {O}}({\overline{n}})$$

O
(

n
¯

)

, where $${\overline{n}}$$

n
¯

is a supernatural number. We compute its $$*$$

∗

-regular closure, and this allows us to fully characterize the set of $${\mathcal {O}}({\overline{n}})$$

O
(

n
¯

)

-Betti numbers.
Writers and politics: Gisèle Sapiro’s advances within the Bourdieusian sociology of the literary field
Authors: Fowler Bridget 
Published: June 2021

AbstractThis article undertakes a critical analysis of the work of Gisèle Sapiro, with reference to sociology of literature. From 1999 (Sapiro, 2014a), Sapiro has developed the Bourdieusian research tradition, amplifying especially Bourdieu’s theory of crisis. Focusing on the antagonisms between literary “prophets” and “priests”, she has drawn on a rich sample of 184 writers to elucidate the struggles inherent in World War II between writers from different field positions and literary habitus. Further, her historical analyses of the ethical commitments of nineteenth century writers via a fresh microsociology of literary trials (Sapiro, 2011) has reminded us of the importance of popular poets in articulating the suffering of the subordinate classes. Her most recent book (Sapiro, 2018) has expanded on her earlier themes, whilst identifying the recuperation of certain 1930s’ fascist worldviews within contemporary literature. This article notes that there is a telling divergence between Bourdieu and Sapiro on the issue of interests behind disinterestedness, exemplified in the case of Zola. On this issue, Sapiro’s reading (Sapiro, 2011) is found convincing. Finally, the dialectic of avant-garde consecration and routinisation is questioned as a universal structure. It is suggested that certain avant-garde – the Harlem Renaissance, for example – did not undergo swift consecration or routinisation, although this contention deserves greater research. The paper concludes by showing that Sapiro’s conception of writers’ responsibility owes its origins less to Sartre than to the Durkheimian/ Bourdieusian notion of the expertise of the “specific intellectual”. It welcomes Sapiro’s concern for literature as a potential force for social change.
The clinical significance of anomalous experience in the explanation of monothematic delusions
Authors: Noordhof Paul , Sullivan-Bissett Ema 
Published: June 2021

AbstractMonothematic delusions involve a single theme, and often occur in the absence of a more general delusional belief system. They are cognitively atypical insofar as they are said to be held in the absence of evidence, are resistant to correction, and have bizarre contents. Empiricism about delusions has it that anomalous experience is causally implicated in their formation, whilst rationalism has it that delusions result from top down malfunctions from which anomalous experiences can follow. Within empiricism, two approaches to the nature of the abnormality/abnormalities involved have been touted by philosophers and psychologists. One-factor approaches have it that monothematic delusions are a normal response to anomalous experiences whilst two-factor approaches seek to identify a clinically abnormal pattern of reasoning in addition to anomalous experience to explain the resultant delusion. In this paper we defend a one-factor approach. We begin by making clear what we mean by atypical, abnormal, and factor. We then identify the phenomenon of interest (monothematic delusion) and overview one and two-factor empiricism about its formation. We critically evaluate the cases for various second factors, and find them all wanting. In light of this we turn to our one-factor account, identifying two ways in which ‘normal response’ may be understood, and how this bears on the discussion of one-factor theories up until this point. We then conjecture that what is at stake is a certain view about the epistemic responsibility of subjects with delusions, and the role of experience, in the context of familiar psychodynamic features. After responding to two objections, we conclude that the onus is on two-factor theorists to show that the one-factor account is inadequate. Until then, the one-factor account ought to be understood as the default position for explaining monothematic delusion formation and retention. We don’t rule out the possibility that, for particular subjects with delusions there may be a second factor at work causally implicated in their delusory beliefs but, until the case for the inadequacy of the single factor is made, the second factor is redundant and fails to pick out the minimum necessary for a monothematic delusion to be present.
Knowledge and reasoning
Authors: Simion Mona 
Published: June 2021

AbstractThis paper develops a novel, functionalist, unified account of the epistemic normativity of reasoning. On this view, epistemic norms drop out of epistemic functions. I argue that practical reasoning serves a prudential function of generating prudentially permissible action, and the epistemic function of generating knowledge of what one ought to do. This picture, if right, goes a long way towards normatively divorcing action and practical reasoning. At the same time, it unifies reasoning epistemically: practical and theoretical reasoning will turn out to be governed by the same epistemic norm—knowledge—in virtue of serving the same epistemic function: generating knowledge of the conclusion.
Should I Stay, or Should I Go? Job satisfaction as a moderating factor between outcome expectations and entrepreneurial intention among academics
Authors: Blaese Richard , Noemi Schneider , Brigitte Liebig 
Published: June 2021

AbstractBoth psychological and entrepreneurship research have highlighted the pivotal role of job satisfaction in the process of entrepreneurial career decisions. In support of this, mounting evidence point to inter-relationships between entrepreneurial intention, job satisfaction, and organizational commitment. Prior research operationalized entrepreneurial careers as an escape from poor work environments; thus, there is a lack of understanding regarding how job-satisfaction can trigger entrepreneurship within and related to the environment of universities. This study, draws on Social Cognitive Career Theory and the concept of entrepreneurial intention, to address whether the role of job satisfaction is a moderating factor between outcome expectations and entrepreneurial intention. Furthermore, we examine to what extent (I) entrepreneurial intention and (II) spin-off intention are determined by certain outcome expectations and perceived behavioral control. To address these questions this study examined academic researchers in specialized and non-technical fields and builds on a survey of 593 academic researchers at Swiss Universities of Applied Science. The results showed that outcome expectations are a significant predictor for entrepreneurial intentions, in general, and spin-off intentions, in particular. A multi-group analysis corroborated that job satisfaction operates as a motivational factor in entrepreneurial transition and interactions with entrepreneurial outcome expectations. In conclusion, the concept of job satisfaction and Social Cognitive Career Theory were powerful constructs to better the understand the process of entrepreneurial career decisions by academic researchers.
Krisendiagnosen aus sozialpädagogischer Sicht
Authors: Dollinger Bernd 
Published: June 2021

ZusammenfassungKrisendiagnosen begleiten die Soziale Arbeit seit ihren Anfängen. Gerade derzeit wird umfassend von Krisen gesprochen. Allerdings sollte beachtet werden, welche Voraussetzungen und – möglicherweise unbeabsichtigten – Folgen dies mit sich bringt.
Current Status of Human Papillomavirus-Related Head and Neck Cancer: From Viral Genome to Patient Care
Authors: Dong Haoru , Shu Xinhua , Xu Qiang , Zhu Chen , Kaufmann Andreas M. , Zheng Zhi-Ming , Albers Andreas E. , Qian Xu 
Published: June 2021

AbstractHuman papillomavirus (HPV) infection identified as a definitive human carcinogen is increasingly being recognized for its role in carcinogenesis of human cancers. Up to 38%–80% of head and neck squamous cell carcinoma (HNSCC) in oropharyngeal location (OPSCC) and nearly all cervical cancers contain the HPV genome which is implicated in causing cancer through its oncoproteins E6 and E7. Given by the biologically distinct HPV-related OPSCC and a more favorable prognosis compared to HPV-negative tumors, clinical trials on de-escalation treatment strategies for these patients have been studied. It is therefore raised the questions for the patient stratification if treatment de-escalation is feasible. Moreover, understanding the crosstalk of HPV-mediated malignancy and immunity with clinical insights from the proportional response rate to immune checkpoint blockade treatments in patients with HNSCC is of importance to substantially improve the treatment efficacy. This review discusses the biology of HPV-related HNSCC as well as successful clinically findings with promising candidates in the pipeline for future directions. With the advent of various sequencing technologies, further biomolecules associated with HPV-related HNSCC progression are currently being identified to be used as potential biomarkers or targets for clinical decisions throughout the continuum of cancer care.