bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis POM QM V5.2 For Windows pada Penerapan Metode ABC dan EOQ Dalam Pengendaliaan Persediaan Bahan Baku PVC Compound (Studi Kasus PT.SMI)
Authors: Widodo Amin Widodo 
Published: April 2021

<p>Abstrak : </p><p>PT. SMI Perusahaan konsisten dalam menerapkan ISO 9001: 2015 dalam upaya tersebut yang dilakukan perusahaan yaitu menginginkan pengendalian persediaan lebih terpola. Tujuan penelitian untuk mengetahui bahan baku yang membutuhkan monitoring sangat ketat dengan Metode <em>ABC</em> dan <em>EOQ</em>. Metode penelitian yang digunakan kuantitatif, diskriptif dengan cara observasi dan wawancara, metode untuk penyeselesaian Riset Operasi menggunakan perangkat lunak berbasis <em>POM QM V5.2 For Windows</em>. Hasil observasi data kebutuhan bahan baku, biaya persediaan akan di lakukan proses pengolahan data dengan menggunakan metode <em>inventory ABC</em> dan <em>EOQ</em> dengan bantuan Tools teknologi informasi <em>POM QM V5.2 For Windows</em>, Hasil penelitian <em>ABC</em> Analisys menujukan bahan baku yang membutuhkan monitoring sangat ketat yaitu <em>PVC</em> 66, <em>Stabilizer</em>, dan <em>PVC</em> 71, <em>Lubricant</em> 16A, dan <em>Lubricant 15 </em>. Hasil penelitian Metode <em>EOQ</em> berpengaruh positif, keuntungan perusahaan akan meningkat karena terjadi efisiensi biaya pembelian bahan baku yaitu <em>PVC</em> 66 menghemat biaya rata-rata Rp 96.321.440,00 atau 44%, <em>Stabilizer</em> menghemat biaya rata-rata Rp 4.634.959,00 atau 57%, <em>PVC</em> 71 menghemat biaya rata-rata Rp 49.304.566.00 atau 38%, <em>Lubricant</em> 16A menghemat biaya rata-rata Rp 869.640,7 atau 38%, <em>Lubricant 15 </em> menghemat biaya rata-rata Rp 1.663.651,38 atau 60%.</p><p>_________________________________</p><p>Abstract :</p><div class="WordSection1"><p><em>PT. The SMI of the Company is consistent in the application of ISO 9001: 2015, in this effort the company does, namely wanting a more patterned inventory control. The research objective is to find out the raw materials that require very strict monitoring with the ABC and EOQ methods. The research method used is quantitative, descriptive by means of observation and interviews, the method for completing Operations Research using software based on POM QM V5.2 For Windows. The results of the observation of data on raw material requirements, inventory costs will be processed using the ABC and EOQ inventory methods with the help of information technology tools POM QM V5.2 For Windows, the results of ABC Analisys research show that raw materials that require very strict monitoring are PVC 66. , Stabilizer, and PVC 71, Lubricant 16A, and Lubricant 15 . The results of the EOQ method research have a positive effect, company profits will increase due to the efficiency of the cost of purchasing raw materials, namely PVC 66 which saves an average of Rp. 96,321,440.00 or 44%, Stabilizer saves an average of IDR 4,634,959.00 or 57%, PVC 71 saves an average of IDR 49,304,566.00 or 38%, Lubricant 16A saves an average of IDR 869,640.7 or 38%, Lubricant 15 saves costs an average of IDR 1,663,651.38 or 60%.</em></p></div>
Ability to Use DFIT to Replace the Minifrac in Sandstone Formations for Reservoir Characterizations
Authors: A. Gabry Mohamed , A. Thabet Samuel , Abdelhaliem Emad , Algarhy Ahmed , Palanivel Maharaja 
Published: April 2021

Abstract
One of essential parts of hydraulic fracture job design optimization in deep sandstone formations is to conduct a minifrac test using fracture fluid to identify the closure pressure for calibration of the stress profile and to calibrate the leak-off coefficient of the fracturing fluid, but the test could not provide good understanding for reservoir properties of permeability, reservoir pressure, and intensity of natural fractures.
By conducting the actual DFIT (Diagnostic Fracture Injection Test) and minifrac in more than thirty wells in different formations from different fields, several leak-off behaviors are observed and several conclusions can be reached by integrating minifrac, DFIT, geologic settings information, and production data.
With the experience of conducting high rate and low rate DFIT before minifrac jobs, we can conclude that there are several benefits for the DFIT by replacing the minifrac, which conventionallyusesg a polymer fracturing fluid, with a non-wall-building fluid consisting mainly of water from the operations and job design perspective, and from the post frac production perspective. DFIT with water can introduce the best methodology to detect the induced complexity that may cause hydraulic fracture job cancellation in cases of detecting high complexity value early before rig movement. Implementing DFIT in a complete hydraulic fracturing design, execution and evaluation workflow can provide a deep understanding of the fracture geometry propagation and reservoir characterization. The main disadvantages of the DFIT is that it requires a long leak-off observation period but that can be minimized in the mD range of sandstone permeability.
This paper introduces DFIT in sandstone formations as a good method for integration between the geology, reservoir management, and fracture operations. The paper provides the operational and integral benefits of replacing minifrac and fracturing fluid with DFIT and water in deep sandstone formations, which provides more accurate data analysis because testing is done with same fluid. In addition, it can reduce fracture operations cost by 10%.
Selection for CD26- and CD49A+ cells from pluripotent stem cells-derived islet-like clusters improves therapeutic activity in diabetic mice
Authors: Molakandov Kfir , Berti Denise A. , Beck Avital , Elhanani Ofer , Walker Michael D. , Soen Yoav , Yavriyants Karina , Zimerman Michal , Volman Ella , Toledo Itzik , Eruhimovich Anna , Levy Alon M. , Hasson Arik , Itskovitz-Eldor Joseph , Chebath Judith , Revel Michel 
Published: April 2021

Abstract
Background. Cell therapy of diabetes aims at restoring the physiological control of blood glucose by transplantation of functional pancreatic islet cells. A potentially unlimited source of cells for such transplantations would be islet cells derived from an in vitro differentiation of human pluripotent stem cells (hESC/hiPSC). The islet-like clusters (ILC) produced by the known differentiation protocols contain various cell populations. Among these, the β-cells that express both insulin and the transcription factor Nkx6.1 seem to be the most efficient to restore normoglycemia in diabetes animal models. Our aim was to find markers allowing selection of these efficient cells. Methods. Functional Cell-Capture Screening (FCCS) was used to identify markers that preferentially capture the cells expressing both insulin and Nkx6.1, from hESC-derived ILC cells. In order to test whether selection for such markers could improve cell therapy in diabetic mouse models, we used ILC produced from a clinical-grade line of hESC by a refined differentiation protocol adapted to up-scalable bioreactors. Re-aggregated MACS sorted cells were encapsulated in microspheres made of alginate modified to reduce foreign body reaction. Implantation was done intraperitoneally in STZ-treated C57BL/6 immuno-competent mice. Results. CD49A (integrin alpha1) was identified by FCCS as a marker for cells that express insulin (or C-peptide) as well as Nkx6.1 in ILC derived by hESC differentiation. The ILC fraction enriched in CD49A+ cells rapidly reduced glycemia when implanted in diabetic mice, whereas mice receiving the CD49A depleted population remained highly diabetic. CD49A-enriched ILC cells also produced higher levels of human C-peptide in the blood of transplanted mice. However, the difference between CD49A-enriched and total ILC cells remained small. Another marker, CD26 (DPP4), was identified by FCCS as binding insulin-expressing cells which are Nkx6.1 negative. Depletion of CD26+ cells followed by enrichment for CD49A+ cells increased insulin+/Nkx6.1+ cells fraction to ~70%. The CD26-/CD49A+ enriched ILC exhibited improved function over non-sorted ILC or CD49A+ cells in diabetic mice and maintain prolonged blood C-peptide levels.Conclusions. Refining the composition of ILC differentiated from hPSC by negative selection to remove cells expressing CD26 and positive selection for CD49A expressing cells could enable more effective cell therapy of diabetes.
Role of pre-transplant corneal injective anti VEGF treatment in high risk transplantation corneas
Authors: Fasciani Romina , crincoli Emanuele , Mosca Luigi , Guccione Laura , Caristia Alice , Rizzo Stanislao 
Published: April 2021

Abstract
Background

In “high-risk” corneal graft recipients, like those with neovascularization of the cornea, the failure rate can exceed 35% at three years, the main cause being graft rejection. The main purpose of the study is to demonstrate the efficacy of pre-transplant Bevacizumab corneal injection in long term lowering of the prevalence of graft failure and rejection in high risk corneal transplantations.

Methods

This retrospective single-centre case-control study analyzed 37 eyes with significant corneal neovascularization and eligible for corneal transplantation at baseline. One group (BT group) included patients who were treated with a 3 months preoperative cycle of subconjunctival and/or intrastromal 5 mg/0.2 ml Bevacizumab injected at the limbus with a 27 G needle. The control group (NT group) didn’t receive the preoperative treatment. The main outcome was the prevalence of graft failures and rejections during the follow up period. Secondary outcomes included the prevalence of adverse events and the prevalence of patients who avoided corneal transplantation due to the treatment.

Results

BT group included 24 eyes with a follow up duration of 61.2 ± 24 months. Eight patients (33.3%) avoided transplant surgery after the injection. In the BT group 5 cases of graft failure (20.8%), 1 of which due to graft rejection (4%), occurred during the follow up. The NT group registered 6 cases (46.1%) of immune rejection of the graft and no additional graft failures from other causes.

Conclusions

Pre-transplant bevacizumab corneal injections are a safe and effective method to prevent graft rejection in neovascularized corneas.
Breathing modulates cortico-hippocampal dynamics during offline states
Authors: Karalis Nikolaos , Sirota Anton 
Published: April 2021

Abstract
Network dynamics have been proposed as a mechanistic substrate for the information transfer across cortical and hippocampal circuits. During sleep and offline states, synchronous reactivation across these regions underlies the consolidation of memories. However, little is known about the mechanisms that synchronize and coordinate these processes across widespread brain regions. Here we address the hypothesis that breathing acts as an oscillatory pacemaker, persistently coupling distributed brain circuit dynamics. Using large-scale recordings from seven cortical and subcortical brain regions in quiescent and sleeping mice, we identified a novel global mechanism, termed respiratory corollary discharge, that co-modulates neural activity across these circuits. Analysis of inter-regional population activity and optogenetic perturbations revealed that breathing rhythm couples hippocampal sharp-wave ripples and cortical DOWN/UP state transitions by jointly modulating excitability in these circuits. These results highlight breathing, a perennial brain rhythm, as an oscillatory scaffold for the functional coordination of the limbic circuit, supporting the segregation and integration of information flow across neuronal networks during offline states.
Stimulating Lifestyle is associated with Maintenance of White Matter Integrity with Age
Authors: Ducharme-Laliberté Gabriel , Mellah Samira , Belleville Sylvie 
Published: April 2021

Abstract
Brain maintenance refers to the fact that some older adults experience few age-related changes in the brain, which helps maintain their cognition. Objectives. The goals of this study are to assess maintenance of white matter integrity, test whether lifestyle factors affect the maintenance of white matter integrity, and measure whether maintenance of white matter integrity explains inter-individual differences in working memory (WM). Methods. Forty-one cognitively healthy older adults received a structural magnetic resonance imaging (MRI) examination to measure white matter lesions. They completed an n-back WM task with different loads (1- & 2-back), along with a questionnaire on their lifestyle. Results. There was a positive association between age and volume of white matter lesions. This association was no longer found in those with higher lifestyle scores. In addition, smaller volumes of white matter lesions were associated with better performance than expected for age in the 1-back WM task. Discussion. Better WM in older adults is associated with maintenance of white matter integrity, which in turn is linked to a more stimulating lifestyle throughout life.
FLAG: Fuzzy Logic Augmented Game Theoretic Hybrid Hierarchical Clustering Algorithm for Wireless Sensor Networks
Authors: Naik Chandra , D Pushparaj Shetty 
Published: April 2021

Abstract
Stability of the Wireless Sensor Network(WSN) is the most critical factor in real-time and data-sensitive applications like military and surveillance systems. Many energy optimization techniques and algorithms have been proposed to extend the stability of a wireless sensor network. Clustering is a well regarded method in the research communities among them. Hence, this paper presents hybrid hierarchical artificial intelligence based clustering techniques, named FLAG and I-FLAG. The first phase of these algorithms use game theoretic technique to elect suitable cluster heads(CHs) and later phase of the algorithms use fuzzy inference system to select appropriate super cluster heads(SCHs) among CHs. The I-FLAG is an improved version of FLAG where additional parameters like energy and distance are considered to elect CHs. Simulations are performed to check superiority of the proposed algorithms over the existing protocols like LEACH, CHEF, and CROSS. Simulation results show that the average stability period of WSN is better in FLAG and I-FLAG compared to other protocols, and so is the throughput of WSN during the stability period.
The Deceleration of Radio/Light Transmission; A Collision Mechanism Dependent Radio Signal Emission, Transmission, and Reception
Authors: Zhang Jing 
Published: April 2021

Abstract
The fast and slow fading of radio signal transmissions or laser beam itself and its spare light confirm the presence of two kinds of collisions --- electron-photon and photon-photon collision. Photon transmissions of radio signals are either in consecutive dense photon groups in slow fading process or widespread group pattern in fast fading form. The photon transmission shapes are irregular and dynamical changes. The radio frequency shift and the wavelength reduction by the calculation demonstrate decelerations of radio/light transmission speeds due to the gradual reduced distance between two consecutive photon groups along the transmission pathway. Photons from radio signals are able to affect electron movements in radio signal receiving process and electrons able to kick photons into space during radio signal emission. The pattern of free electron movement under the influence of local electromagnetic force in antenna is consistent with the randomly dynamic changes of radio signal in space. The fast fading is due to the collision of consecutive photon groups of signals in slow fading with free photons in space. The mathematical equation for the relationship between light/radio transmission speeds before and after photons collisions is established. The equation is confirmed by the calculations of well-known difference of light transmission speeds in different media. The gravities from Earth and Sun play little role during light/radio transmission.
Drilling Vibration Modes and Penetration Rate Modeling using Artificial Neural Network and Multiple Linear Regression Analysis in Khoman Formation at the Egyptian Western Desert
Authors: Ezz Sherif A. , Farahat Mohamed S. , Kamel Said , Nouh Ahmed Z. 
Published: April 2021

Abstract
Drill string vibrations are one of the most serious problems encountered while drilling as the bit and drill string interaction with formations under certain drilling conditions usually induces complex shocks and vibrations into the drill string components resulting in premature failure of the equipment and reduced drilling penetration rate. In severe cases where shocks and vibrations accumulated into drill string till exceeded its maximum yield or torsional strength, fatigue will occur and thereby increase the field development costs associated with replacing damaged components, fishing jobs, lost-in-hole situations, and sidetracks. Thus, real-time monitoring for downhole generated vibrations and accordingly adjusting drilling parameters including weight on bit, rotary speed, and circulation rate play a vital role in reducing the severity of these undesirable conditions. Vibration optimization must be done incorporation with the penetration rate, as a minimum economical penetration rate is required by the operator. In this study, three penetration rate and vibration level models were developed for axial, lateral, and stick-slip drilling modes using both MATLAB™ Software neural network and multiple regression analysis. It is found that the three models' results for vibration level and penetration rate; as compared with those recorded drilling data; showed an excellent match within an acceptable error of average correlation coefficient (R) over 0.95. The prediction of penetration rate and vibration level is thoroughly investigated in different axial, lateral, and stick-slip vibration drilling modes to be able to best select the optimum safe drilling zone. It is found that the axial vibration could be dampened by gradually increasing the weight on bit and increasing rotary speed while both the lateral and torsional vibrations are enhanced by increasing the rotary speed and decreasing the weight on bit.
Porous Covalent Organic Nanotubes and Toroids: A Carbon Nanotube Analogue
Authors: Banerjee Rahul , Koner Kalipada , Karak Shayan , Kandambeth Sharath , Karak Suvendu , Thomas Neethu , Leanza Luigi , Perego Claudio , Pesce Luca , Capelli Riccardo , Moun Monika , Bhakar Monika , Ajithkumar T. G. , Pavan Giovanni 
Published: April 2021

Abstract
Despite the noteworthy progress made in the nanotubular architectures with well-defined lengths and diameter, the synthesis of a purely covalent bonded organic nanotube, so far, proved to be elusive. Our work includes a hitherto unavailable structure, "Covalent Organic Nanotubes (CONTs)," to the repertoire. Strong covalent bonds between C, N, and O imparts high thermal and chemical stability of CONTs. This novel bottom-up approach provides an edge over the carbon nanotubes (CNTs) in functionalization, synthetic conditions, and porosity. CONT-1 exhibits a BET surface area of 321 m2g-1. These flexible CONTs intertwine with each other. The computational studies establish the role of solvent as the critical driving force for this type of convolution. Upon ultrasonication, the intertwined CONT-1 coil to form the toroidal superstructure.
Polymorphism of MMP-3 Gene and Imbalance Expression of MMP-3 / TIMP-1 in Articular Cartilage Are Associated With an Endemic Osteochondropathy, Kashin- Beck Disease
Authors: Shi Bohui , Guo Xiong , lv Aili , Zhang Zengtie , Shi Xiaowei 
Published: April 2021

Abstract
Background: The etiology of Kashin-Beck disease (KBD), an endemic osteochondropathy, is largely unknown. Matrix metalloproteinase-3 (MMP-3) plays a central role in the initiation and progression of cartilage destruction, however，no study has reported on the relationship between KBD and MMP-3. The objective of this study was to explore the polymorphism of MMP-3 gene and expression of MMP-3 / TIMP-1(Tissue inhibitors of matrixmetalloproteinases-1) in the pathogenesis of KBD.Methods: Single nucleotide polymorphism (SNP) genotyping was conducted in 274 KBD cases and 248 healthy controls for eight SNPs in MMP-3 using the Sequenom MassARRAY system. Additionally, the expression of MMP-3、TIMP-1 in different layers of the articular cartilage was analyzed by immunohistochemistry for 22 KBD patients, 15 osteoarthritis (OA) patients and 21 controls.Results: The results showed that six SNPs (rs520540、rs591058、rs679620、rs602128、rs639752 and rs678815) in MMP-3 were associated with the increased risk of KBD, however, after Bonferroni correction, only the SNP rs679620 in the recessive model remained significant difference (OR=2.31, 95%CI=1.29-4.14, P=0.0039), homozygous for “T” allele have a risk for KBD than "C" allele carriers. Moreover, the percentages of cells expressing MMP-3 in articular cartilage were significantly higher in the KBD and OA groups than in the controls (t=5.37 and 4.19，P＜0.01).While the KBD and OA groups had lower levels of TIMP-1 positive staining compared with the controls (t=5.23and 5.06，P＜0.01). And there was no significant different between KBD and OA for the levels of MMP-3 and TIMP-1 positive staining (t=0.05and 0.28，P＞0.05). Conclusions: MMP-3 is associated with the susceptibility of KBD, and the imbalance expression of MMPs / TIMPs leading to cartilage degradation may play an important role in cartilage degradation and osteoarthritis formation in OA and KBD.
Validation of Molecular Markers Linked to Fusarium Wilt Resistance in Recombinant Inbred Lines of Chickpea (Cicer arietinum L.)
Authors: Lal Dalpat , Ravikumar Rampura Lakshmipathi , Jingade Pavankumar , Subramanya Sunil 
Published: April 2021

Abstract
Molecular markers closely linked to Fusarium wilt resistance in chickpea were identified from earlier studies with an objective to validate them. The recombinant inbred line (RIL) mapping population (F11) derived from JG62 (FW susceptible) and WR315 (FW resistant) was used for validation of linked markers. The RILs were phenotyped for FW resistance over two seasons in a wilt sick field at ICRISAT and in wilt sick pots under the green house condition. A total of 42 markers linked to Fusarium wilt (FW) resistance in chickpea were selected from earlier reports for validation. Among 42 markers selected 23 markers were polymorphic among the parental lines of RIL population and hence these markers were used for genotyping the mapping population. The genotyping data together with phenotyping data over two seasons and wilt sick pots identified 12 markers linked to wilt resistance by single marker analysis. The markers TA96, CS27, TA110 and TA59 were more consistently related to FW resistance in this and previous studies. The composite interval mapping has identified two major loci; one each in LG1 and LG2 flanked by markers H4G11 and CaM1402 and H3A12 and CS27, respectively. These two loci are considered as major loci for FW resistance explaining up to 76.66% of phenotypic variation for FW resistance. The results presented here and those published earlier confirm the emerging picture of two hotspots in chickpea genome for resistance to Fusarium wilt. The QTL flanking markers, H4G11, CaM1402, CS27, and H3A12 are most promising and reliable for deployment in chickpea breeding.