bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Validated Method for the Estimation of Capecitabine and Docetaxel Using RP-UPLC
Authors: Devi Potturi. Rama , Rambabu Kantipudi 
Published: October 2021

Aims: Study on degradation of Capecitabine and Docetaxel based on a new, validated method using UPLC.
Place and Duration of Study: Department of Chemistry, RVR & JC College of Engineering, Chowdavaram, Guntur, Andhra Pradesh, between February 2021 and August 2021.
Methodology: With a flow rate of 1 mL/min and a wave length of 255 nm, the proposed method successfully separated the target metabolite using a Symmetry C18 column (150 mm x 4.6mm,3.5 µm), acetonitrile, and 0.1 percent ortho phosphoric acid (OPA) as the mobile phase. The retention times for Capecitabine and Docetaxel were 1.223 minutes and 1.864 minutes, respectively. The isocratic chromatography procedure took about ten minutes to complete at room temperature.
Results: The analysis was completed in three minutes with a concentration range of 5-75 µg/mL capecitabine and 2-30 µg/mL docetaxel that was honest in linearity. The system's suitability parameters were examined mathematically, and the outcomes fell within acceptable ranges. Stages with regression coefficients of 0.999 were used in the linear analysis. Capecitabine's LOD and LOQ concentrations were 1.5 µg/mL and 5 µg/mL, respectively, while Docetaxel was 0.6 µg/mL and 2 µg/mL. 98-102% of the drug was recovered, which means the recovery was within acceptable limits.
Conclusion: The approach was found to be suitable for bulk and formulation analysis after the validation results were satisfactory. According to ICH guidelines, the recommended procedure was found to be justified.
Validated Capillary Zone Electrophoretic Determination of Avanafil and Dapoxetine Hydrochloride in their Pure form and Pharmaceutical Preparation
Authors: Ali Mohamed B. , Talaat Wael , Omran Gamal A. , Hendawy Hassan A. M. , Morshedy Samir 
Published: October 2021

Aims: In this study, a simple, green, and rapid capillary zone electrophoresis (CZE) method coupled with a diode array detector (DAD) was applied for the analysis of avanafil (AVA) and dapoxetine hydrochloride (DAP) as a binary mixture using vardenafil (VAR) as an internal standard (IS) in pure form and pharmaceutical formulation.
Methodology: The separation was done using fused silica capillary (58.5 cm total length, 50 cm effective length, and 50 μm internal diameter) and the running background electrolyte (BGE) was 100 mM acetate buffer at pH 3.6. During the separation process, the applied voltage was 30 KV, while the temperature was 25 °C. The sample injection was applied at a pressure of 50 mbar for 10 s, and detection was carried out at 210 nm for DAP and 248 nm for AVA and VAR.
Results: Analysis of the tested drugs and the internal standard was carried out in less than 6.5 min, where the migration times were 4.29, 4.90, and 6.02 min for IS, DAP and AVA respectively. The proposed method showed linearity in the concentration range 5-80 and 5-70 μg/mL with correlation coefficients 0.9996 and 0.9999 for AVA and DAP respectively. The limit of detection (LOD) was 0.523 and 0.531 for AVA and DAP respectively, while the limit of quantification (LOQ) was 1.585 and 1.608 in respective order. The Peak purity and identity in the proposed method were validated by DAD.
Conclusion: The proposed CZE method was validated according to ICH guidelines and applied successfully for the estimation of AVA and DAP in their combined pharmaceutical preparation.
Directional Chiral Exciton Emission via Topological Polarization Singularities in all Van der Waals Metasurfaces
Authors: Wang Yuefeng , Huang Di , Xia Meng , Zhou Jiaxin , Chen Yuhua , Liao Yinchang , Zhang Xingwang 
Published: December 2024

AbstractMonolayer transition metal dichalcogenides (TMDs) with strong exciton effects have enabled diverse light emitting devices, however, their Ångstrom thickness makes it challenging to efficiently manipulate exciton emission by themselves. Although their nanostructured multi‐layer counterparts can effectively manipulate optical field at deep subwavelength thickness scale, these indirect band gap multi‐layer TMDs are lack of strong luminescence, hindering their applications in light emitting devices. Here, the integration of monolayer TMDs is presented with nanostructured multi‐layer TMDs, combining both strong exciton emission and optical manipulation in a single ultra‐thin platform. Leveraging the topological polarization singularities in the all van der Waals metasurfaces, chiral exciton emission is experimentally demonstrated whose directionality can be controlled by tailoring metasurface's symmetry. These results provide an approach that can realize exciton emitting devices fully based on 2D materials with controllable polarization and directionality, and may unfold a new avenue for multi‐functional 2D semiconductor light sources.
Development and Applications of Polypyrrole‐Based Conductive Inks: An Overview
Authors: Meenakshy Suresh , Jesslyn John , Anas Saithalavi 
Published: December 2024

AbstractDue to their flexibility, high conductivity, stability, monodispersity, and ease of processing; polypyrrole‐based conductive inks hold significant advancements in printing, biomedical and electronic applications. These inks enable innovative solutions in flexible electronics, wearable devices, sensors, and energy storage systems and also facilitate high‐quality printed films on various rigid and flexible substrates, supporting diverse applications from flexible circuits to smart textiles. Notably, in biomedicine, they exhibit excellent biocompatibility, and cell adhesion, aiding in tissue engineering and stem cell therapies. They serve as bioinks for 3D printing free‐standing scaffolds, showing potential for creating electrically active tissue constructs. Additionally, polypyrrole inks are crucial for developing highly specific and sensitive sensors for detecting gases, chemicals, and biological analytes and efficient energy storage devices like supercapacitors. As research progresses, these inks are pivotal in the future of lightweight, flexible, portable, and wearable electronic materials and devices. This review covers a general overview of various types of polypyrrole‐based conductive inks, highlighting their major applications and impacts.
Itraconazole Reversing Acquired Resistance to Osimertinib in NSCLC by Inhibiting the SHH/DUSP13B/p‐STAT3 Axis
Authors: Zheng Hongmei , Tang Yaoxiang , Zang Hongjing , Luo Jiadi , Zhou Hanqiong , Zhan Yuting , Zou Ying , Wen Qiuyuan , Ma Jian , Fan Songqing 
Published: December 2024

AbstractThere is an urgent necessity to devise efficient tactics to tackle the inevitable development of resistance to osimertinib, which is a third‐generation epidermal growth factor receptor (EGFR) inhibitor used in treating EGFR‐mutant nonsmall cell lung cancer (NSCLC). This study demonstrates that combining itraconazole with osimertinib synergistically reduces the proliferation and migration, enhances the apoptosis of osimertinib‐resistant cells, and effectively inhibits the growth of osimertinib‐resistant tumors. Mechanistically, itraconazole combined with osimertinib promotes the proteasomal degradation of sonic hedgehog (SHH), resulting in inactivation of the SHH/Dual‐specificity phosphatase 13B (DUSP13B)/p‐STAT3 and Hedgehog pathways, suppressing Myc proto‐oncogene protein (c‐Myc). Additionally, DUSP13B interacts with signal transducer and activator of transcription 3 (STAT3) and modulates its phosphorylation. Interestingly, it is observed that SHH overexpression partially rescues the synergistic effects of this combination treatment strategy through the SHH/DUSP13B/p‐STAT3 signaling axis. Moreover, it is found that SHH, (GLI1), p‐STAT3, and DUSP13B play significant predictive roles in osimertinib resistance. In lung adenocarcinoma, p‐STAT3 is positively correlated with SHH but negatively correlated with DUSP13B. Together, these results highlight the crucial role of itraconazole in reversing the acquired resistance to osimertinib and provide a scientific rationale for the therapeutic strategy of combining osimertinib with itraconazole.
Circular‐Gate Nanoscale Air Channel Transistors: Achieving ultralow Subthreshold Swing and Working Voltage
Authors: Zhao Haiquan , Chen Feiliang , Wei Yazhou , Sun Lixin , Huang Ruihan , Wang Xiangdong , Yang Fan , Jiang Hao , Liu Yang , Li Mo , Zhang Jian 
Published: December 2024

AbstractAs electronics advance toward higher performance and adaptability in extreme environments, traditional metal‐oxide‐semiconductor field‐effect transistors (MOSFETs) face challenges due to physical constraints such as Boltzmann's law and short‐channel effects. Nanoscale air channel transistors (NACTs) present a promising alternative, leveraging their vacuum‐like channel and Fowler–Nordheim tunneling characteristics. In this study, a novel circular gate NACT (CG‐NACT) is purposed, fabricated on a 4‐inch silicon‐based wafer using a CMOS‐compatible process. By employing an innovative gate control mechanism, the transistors achieve an ultralow SS of only 0.15 mV dec−1 and maintain the average SS remained at 1.5 mV dec−1 over three decades of drain current. Additionally, our CG‐NACTs deliver milliamper‐level drain current at a low drain voltage of 0.7 V, with a maximum on/off ratio of 7.82×106. Notably, CG‐NACTs remain highly stable even at high temperatures of up to 150 °C and under irradiation. Furthermore, the practical application of CG‐NACTs is successfully implemented by designing an inverter circuit for the first time.
Room‐Temperature Processable Stretchable Conductive Composite Material for Electrical Interfacing in Stretchable Printed Circuit Boards
Authors: Cho Duho , Jang Donggoo , Chae Changju , Kim Sun Hong , Kim Taesu , Lee Su Yeon , Park Jang‐Ung , Choi Youngmin , Jung Sungmook 
Published: December 2024

AbstractThis study introduces a novel Room‐Temperature Processable Stretchable Conductive Composite (RTPSC), uniquely combining room‐temperature processability, stretchability, and conductivity. Unlike traditional conductive materials requiring thermal or UV curing, which can damage heat‐sensitive components or cause substrate distortion, RTPSC uses a Styrene‐Butadiene‐Styrene (SBS) elastomer blended with silver conductive fillers and paraffin oil. This composition enables rapid solidification within five minutes at room temperature, mitigating thermal risks. Surface ligands on silver flakes are replaced with oleylamine, resulting in uniform silver distribution and enhanced resistance to acids, bases, and oxidation. The composite exhibits low contact resistance (0.1 Ω across 7.7 mm2) and maintains robust mechanical and electrical properties under extensive deformation, thanks to its high adhesion force (704.5 gF/25 mm). Notably, contact resistance change remains within 0.15 Ω even after 1800 cycles at 50% strain. RTPSC's viscosity can be finely tuned by adding solvents and secondary fluids, enabling various printing techniques from spray to omni‐directional printing. This adaptability allows intricate patterning on delicate structures via spray printing and versatile connections between stretchable electrodes and rigid components through omni‐directional printing. These capabilities provide extensive design flexibility and ease of repair, making RTPSC highly suitable for innovative development and maintenance of stretchable electronic devices.
Navigating immigrant paths: A case study of unaccompanied youth in foster care
Authors: García María Fernanda , Birman Dina 
Published: December 2024

AbstractUnderstanding the experiences of unaccompanied youths in refugee foster care is important to tailor such systems to support the complex needs and desires of these youth. This instrumental case study sought to understand how a cohort of unaccompanied refugee youth experience refugee foster care as they navigate the “in‐betweenness” of adolescence. Eight youth (ages 17–21) from Guatemala and Honduras, nine foster parents, and two staff were interviewed. A constructivist grounded theory analytic approach was implemented, which resulted in a substantive theory, Growing up to be independent but alone: Navigating tension between paths. This tension results from youth being pulled to adult and child‐like paths by different forces. As youth come of age in the United States, they are expected to fulfill the US vision of adulthood by becoming independent and self‐sufficient. However, definitions of adulthood in their cultures of origin involve interdependence and the responsibility to provide for their families. They experience the pressure to become independent as being alone. Findings underscore the need for comprehensive support systems tailored to address the unique challenges faced by unaccompanied youth during their complex migration journey and transition into independence.
Using community organizing to build a system of care: A mixed methods evaluation
Authors: Santiago Catherine DeCarlo , Biggs Jessica , Serrano Jasmine , Rompala Vikki , Bustos Yvita , Jolie Sarah 
Published: December 2024

AbstractThe purpose of this study was to utilize mixed methods to evaluate the initial implementation of a system of care (SOC) developed and implemented from a community organizing framework. Surveys were conducted with partners (navigators, community partners, parents) to examine changes pre‐ and post‐implementation of the SOC. Surveys assessed care coordination, effectiveness of communication across organizations, quality of services and relationships, barriers, health‐related stressors, and distrust. Surveys were conducted at baseline and follow‐up approximately 1 year later. At baseline, 160 parents and 40 community partners completed surveys. At follow‐up, 125 parents and 33 community partners participated. Qualitative interviews and focus groups were conducted with participating community‐based organization staff (n = 10), community navigators (n = 13), school staff (n = 10), and recipients of services (n = 13). Parent surveys suggested promising improvements in care coordination, communication, and quality of services. These results were supported by qualitative themes describing increased communication, care coordination, relationships, and access to services driven by community navigators. Despite these encouraging findings, surveys completed by community partners did not reveal significant changes. Findings must also be understood within the context of COVID‐19.
Frugality is the new sexy
Authors: Drolet Aimee , Silamahakul Jaijai , Sood Sanjay , Davis Cassandra D. 
Published: December 2024

AbstractThe overarching goal of this article is to spur fresh interest in the topic of frugality and new empirical research on it. To do so, this article presents a series of research propositions that are based on the discussions provided in each section. In particular, the second section of this article reviews philosophical and religious accounts of the concept of frugality. The third and fourth sections focus on consumer psychological research on dispositional frugality. The sixth section reflects on two popular consumer lifestyles, miserliness and simple living, that require certain frugal behaviors but are inspired by non‐frugal values. The seventh section links both frugal and non‐frugal values to two sociological variables: generational cohort and social class. Last, the eighth and ninth sections review new obstacles that consumers face in today's marketplace and how consumers can practice frugality in spite of them.
Mucoadhesive Enhancement of Gelatine by Tannic Acid Crosslinking for Buccal Application
Authors: Ahmady Amina , Anuar Nor Khaizan , Ariffin Siti Alwani , Abu Samah Nor Hayati 
Published: December 2024

ABSTRACTThis study aims to evaluate the impact of formulation parameters on tannic acid‐crosslinked gelatine (GelTA) films, intended as a mucoadhesive matrix for extended buccal drug delivery. GelTA films were prepared using the solvent evaporation technique and screened based on their mucoadhesive and dissolution characteristics. The formulation variables included the source of gelatine (bovine and fish), tannic acid concentration, pH of the film‐forming solutions, and the type and concentration of plasticisers. Subsequently, selected films underwent further characterisation (e.g., crosslinking density, stability) to elucidate their features as a drug delivery matrix. GelTA films exhibited a significantly improved dissolution time compared to the non‐crosslinked film (BG‐GLY20), while maintaining a substantial water uptake capacity conducive to a matrix system with extended action. The bovine GelTA film containing 5% w/w tannic acid and 20% w/w glycerine, prepared at pH 7 (BG‐GLY20‐7), exhibited a 1.6‐fold increase in mucoadhesivity and an extended dissolution time of up to 6 h compared to BG‐GLY20 (control), along with superior antioxidant and antimicrobial properties. However, stability studies indicate the need for an oxygen‐free environment for film storage. In conclusion, GelTA films show promise as a buccal film matrix, offering extended dissolution times, substantial water uptake, and enhanced adhesive strength.
Highly Efficient and Stable Potassium‐Doped g‐C3N4/Zn0.5Cd0.5S Quantum Dot Heterojunction Photocatalyst for Hydrogen Evolution
Authors: Ye Chenxi , Guo Peiyuan , Chen Xiya , Zhang Zining , Guo Yudong , Chen Zhenjun , Yang Huakang , Luo Dongxiang , Liu Xiao 
Published: December 2024

ABSTRACTThe advancement of efficient and robust photocatalysts for water splitting is pivotal for the sustainable production of clean hydrogen energy. This study introduces a novel photocatalyst, synthesized by integrating 0D Zn0.5Cd0.5S quantum dots (ZCS QDs) onto 2D K+‐doped graphitic carbon nitride (K‐CN) microribbons, via an in‐situ hydrothermal growth method. A comprehensive characterization was performed to assess the optical characteristics, structural attributes, and charge transfer efficacy of the prepared photocatalysts. Our findings reveal that the incorporation of K+ ions effectively modulates the bandgap and valence band positions of g‐C3N4, facilitating an optimal energy level alignment with ZCS QDs. Moreover, the integration of ZCS QDs improves the photon capture ability and concurrently diminishes the recombination rate of photogenerated charge carriers. The optimized ZCS 51%/K‐CN photocatalyst demonstrates a promising simulated sunlight‐driven hydrogen production rate of 9.606 mmol·h−1·g−1, surpassing that of pristine ZCS QDs by nearly three times, without the need for noble metal co‐catalysts. Most notably, the photocatalyst maintains its hydrogen evolution performance consistently over five photocatalytic cycles, underscoring its stability. The remarkable photocatalytic activity is primarily ascribed to the formation of a type‐II heterojunction between K‐CN and ZCS QDs, which enhances charge separation and transfer. This research represents a significant step forward in the design of heterojunction photocatalysts by merging QDs with g‐C3N4, offering a highly effective and durable solution for photocatalytic hydrogen production.
Electronic Buffering Mechanism Enhances Stability and Water Oxidation Efficiency of CeO2@NiFe‐LDH
Authors: Shi Junyu , Wang Dandan , Liang Yun , Xu Qunjie , Li Qiaoxia 
Published: December 2024

AbstractNickel‐iron layered double hydroxide shows significant promise as an electrocatalyst in facilitating oxygen evolution reactions. But its development is hindered by low conductivity and insufficient cycling stability. Herein, the synthesis of a hierarchically structured heterostructure catalyst, CeO2@NiFe LDH, is reported through a straightforward two‐step process involving hydrothermal treatment. The catalyst realizes a significant breakthrough in OER catalytic performance and stability. At a current density of 100 mA cm−2, the overpotentials amount to 255 mV in 1 M KOH, 263 mV in simulated seawater with alkaline conditions, and 346 mV in actual alkaline seawater. After 200 hours of continuous operation under high current density in simulated alkaline seawater, the morphology with no significant alterations observed, highlighting its high stability in complex seawater environments. Introducing CeO2 optimizes the binding energy of the OH intermediate, which facilitates the formation and dissociation of the OOH intermediate. In situ Raman analysis demonstrates the positive impact of CeO2 on the generation of active species. This research emphasizes the efficacy of CeO2 in improving the performance and durability of NiFe LDH for oxygen evolution reactions.
Domestic Lentil Production in Bangladesh Is More Advantageous Than Using Overseas Imports
Authors: Sultana Monira , Kazal Mohammad Mizanul Haque , Jalil Gazi M. A. , Shetu Jannatul Ferdous , Sarkar Md. Abdur Rouf , Sujan Md. Hayder Khan 
Published: December 2024

ABSTRACTLentils (Lens culinaris), often referred to as the “meat of the poor,” are essential for ensuring food and nutrition security worldwide, including in Bangladesh. Despite being a staple food, Bangladesh remains heavily dependent on lentil imports to meet domestic demand. However, comprehensive economic analyses comparing domestic lentil production with imports are scarce. This study fills a critical research gap by providing evidence‐based insights into the financial and economic advantages of domestic lentil production over overseas imports, using primary data collected from 196 farmers in central Bangladesh between March and April 2022. The financial profitability analysis revealed a total cost of USD 979.13/ha, generating a net profit of USD 423.55/ha and yielding a benefit–cost ratio of 1.43. However, the economic profitability analysis indicated a lower total cost of USD 692.00/ha, with a net profit of USD 119.37/ha and a benefit–cost ratio of 1.17. Domestic resource cost analysis revealed that local farmers enjoyed a comparative advantage in lentil production. Similarly, the constructed policy analysis matrix (PAM) demonstrated that, at import parity prices, revenue transfers were positive, affirming the economic viability of domestic lentil production. The estimated indicators—including the nominal protection coefficient on output, nominal protection coefficient on input, effective protection coefficient, and private cost ratio—suggest that existing policies effectively safeguard the interests of domestic farmers. To capitalize on this comparative advantage, measures should be implemented to encourage farmers to expand lentil cultivation. Additionally, further research is essential to develop and integrate improved short‐duration lentil varieties within the prevailing rice‐dominated cropping patterns.