bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transnasal Esophagoscopy Examination in Outpatient Unit, Department of Otorhinolaryngology Head and Neck Surgery, Dr. Soetomo Hospital, Surabaya
Authors: Perdana Rizka Fathoni 
Published: January 2021

Esophagoscopy is the standard examination standard for evaluation, diagnosis, screening and surveillance of esophageal diseases. Although it is often done, esophagoscopy costs a lot, is inconvenient, and risks complications, including cardiopulmonary complications because patients usually require routine sedation in the implementation of conventional esophagoscopic procedures. The purpose of this study is to get an overview of the results of the implementation of transnasal esophagoscopy in Department of Otorhinolaryngology Head and Neck Surgery, Division of Broncho-oesophagology, Dr. Soetomo Hospital, Surabaya, between 1 September 2012 and 30 April 2015. This study was a retrospective descriptive study with a population of all patients undergoing esophagoscopic examinations during this period. Data is taken from medical records of new patients undergoing transnasal esophagoscopy. Inclusion criteria were all patients who had been tested for transnasal esophagoscopy, and exclusion criteria were incomplete medical record data. There were 35 patients who underwent transnasal esophagoscopy examination at Department of Otorhinolaryngology Head and Neck Surgery, Division of Broncho-oesophagology, Dr. Soetomo Hospital, Surabayaduring the study period. The mean of patients who participated in the study was 54.17 ± 14.02. 23 male patients (63.89%), while 12 female patients or 34.11%. Indications of dysfagi are found in all age groups, most in the age group 51-70 years. Metastases in head and neck malignancies are found in the age group 31 - 50 years and 51 - 70 years. Indications for heartburn are found in the age group 21-50 years and 51-70 years. In conclusion, the results of transnasal esophagoscopic examination showed that most patients had a normal picture (60%) and a positive picture with an esophageal abnormality of 40%. The most common features are lesions in the mucosal esophagus lumen, scar, masses and stenosis.
Quantity of Antibiotic Use and Resistance Pattern of Gut Normal Flora Escherichia coli at Intensive Care Unit and Tropic Infection Ward, Dr Soetomo Hospital, Surabaya, Indonesia
Authors: Sholeh Mohammad Akbaruddin , Kuntaman Kuntaman , Hadi Usman 
Published: January 2021

Resistance to antibiotics is increasing worldwide, including in Indonesia. The use of antibiotics is the most common cause of microorganism resistance. Individuals who received antibiotic therapy impacton changes of normal micro-flora resistance through selective pressure. This study aims to analyze the relationship of the quantity of antibiotic use with the pattern of resistance of gut normal flora Escherichia coliamong patients in Intensive Care Unit (ICU) and Tropic Infection Ward, Dr. Soetomo Hospital, Surabaya. This study was cross-sectional design with 64 samples (32 the ICU and 32 in Tropic Infection Ward). The total sample were collected for three Months. Identification of intestinal microflora was done with McConkey differential selective medium, followed by IMViC biochemical test, and sensitivity test by antibiotic disc diffusion method. Data were analyzed with Chi square test and Fisher'sExact test. There was no significant difference (p=0.441) in the quantity of antibiotic use between ICU and Tropic Infection Ward. There was no significant difference (p>0.05) in normal intestinal flora Escherichia coli resistance pattern between Tropic Infection Ward and ICU against12 types of antibiotics. Ceftriaxone was the most widely used antibiotic in the Tropic Infection Ward of 54 DDD and ICU of 100 DDD. The highest percentage of intestinal flora Escherichia coli resistance at the ICU was ceftriaxone as manyas 18 (56.3%) and at Tropic Infection Ward on ciprofloxacin and levofloxacin 20 (62.5%). The other study in Primary Health center, showed that theresistance rates of both wards were significantly different as compared to intestinal flora of patients in primary health center (p <0.001), in whichthe use of antibiotics in primary health center was also lower (1.6 DDD). There was no significant difference (p>0.05) The pattern of bacterial resistance between patient with and without antibiotic use at Tropic Infection Ward and ICU Conclusion: the quantity of antibiotic use was not significantly different against resistnt gut flora between patients in ICU and Tropic Infection ward. The pattern of bacterial resistance between patient with and without antibiotic use was also not significantly different.
The Role of Cyclin D1 and VEGF in Radiotherapy Response of Advance Stage Undifferentiated Nasopharyngeal Carcinoma
Authors: Nurhidayat Ade Apon , Afiati Afiati , Usman Hermin Aminah , Hernowo Bethy Suryawathy 
Published: January 2021

Nasopharyngeal carcinoma has a high incidence and mortality rate in Southeast Asia and Indonesia. Radioresistance is a major obstacle to successful treatment of nasopharyngeal carcinoma. DNA repair in the cell cycle and angiogenesis factors affects the response of tumor cells to radiotherapy. Cyclin D1 that functions in the cell cycle process and VEGF as an angiogenesis factor are considered to play a role in the occurrence of radioresistance. The objective of this study is to find the association between immunoexpression of Cyclin D1 and VEGF with radiotherapy response in undifferentiated nasopharyngeal carcinoma. This study used a retrospective case control analysis design, secondary data from medical records of patients diagnosed as undifferentiated nasopharyngeal carcinoma who received complete radiotherapy at the Radiation Oncology Department Dr Hasan Sadikin Bandung were taken. There were 44 samples divided into radiosensitive (22 samples) and radioresistant (22 samples) groups. Immunohistochemical examination of Cyclin D1 and VEGF was performed on paraffin blocks of patients' biopsy. Data analysis using Chi-Square test (p ≤0.05) , OR 95% CI. Cyclin D1 expressed strongly in 86.4% of the radioresistant group and 59.1% in the radiosensitive group (p<0.05) and the OR 4,385 (0.993-19.356), VEGF was strongly expressed in 77.3% of the radioresistant group and 54.5% in the radiosensitive group (p>0.05). As conclusion, there were significant association between Cyclin D1 with radiotherapy respons in undifferentiated nasopharyngeal carcinoma. The stronger immunoexpression of Cyclin D1, the higher likelihood of radioresistancy. VEGF immunoexpression showed no significant association with radiotherapy response.
Defeating JUUL’s Effort to Rewrite San Francisco’s E-Cigarette Regulations
Authors: Sircar Neiloy R. , Glantz Stanton A. 
Published: January 2021

In 2019, San Francisco, California, prohibited the sale of electronic cigarettes lacking US Food and Drug Administration authorization. JUUL then promoted a ballot initiative (Proposition C) to replace San Francisco’s e-cigarette legislation with legislation JUUL wrote that required future legislation to be approved by the voters. JUUL promoted Proposition C as a way to reduce youth e-cigarette use while allowing adult choice. Health groups argued that JUUL’s measure could nullify San Francisco’s prohibition on selling flavored tobacco products. Health groups benefitted from having an established campaign network that recently defended the flavor ban. They successfully framed Proposition C as a tobacco industry ploy to undo San Francisco’s e-cigarette regulations, particularly the prohibition on selling flavored tobacco products. JUUL ended its campaign on September 30, 2019, and the measure failed on election day, with 82% voting against it. Lessons learned from the campaign include the importance of framing an industry initiative as a threat to local public health lawmaking and the potential for the e-cigarette issue to attract parents as new leaders and engage a powerful constituency to support tobacco control measures.
Monitoring Sexual Violence Trends in Emergency Department Visits Using Syndromic Data From the National Syndromic Surveillance Program—United States, January 2017–December 2019
Authors: D'Inverno Ashley Schappell , Idaikkadar Nimi , Houry Debra 
Published: January 2021

Objectives. To report trends in sexual violence (SV) emergency department (ED) visits in the United States. Methods. We analyzed monthly changes in SV rates (per 100 000 ED visits) from January 2017 to December 2019 using Centers for Disease Control and Prevention’s National Syndromic Surveillance Program data. We stratified the data by sex and age groups. Results. There were 196 948 SV-related ED visits from January 2017 to December 2019. Females had higher rates of SV-related ED visits than males. Across the entire time period, females aged 50 to 59 years showed the highest increase (57.33%) in SV-related ED visits, when stratified by sex and age group. In all strata examined, SV-related ED visits displayed positive trends from January 2017 to December 2019; 10 out of the 24 observed positive trends were statistically significant increases. We also observed seasonal trends with spikes in SV-related ED visits during warmer months and declines during colder months, particularly in ages 0 to 9 years and 10 to 19 years. Conclusions. We identified several significant increases in SV-related ED visits from January 2017 to December 2019. Syndromic surveillance offers near-real-time surveillance of ED visits and can aid in the prevention of SV.
First-Destination Outcomes for 2015–2018 Public Health Graduates: Focus on Employment
Authors: Plepys Christine M. , Krasna Heather , Leider Jonathon P. , Burke Emily M. , Blakely Craig H. , Magaña Laura 
Published: January 2021

Objectives. To improve understanding of the future public health workforce by analyzing first-destination employment outcomes of public health graduates. Methods. We assessed graduate outcomes for those graduating in 2015–2018 using descriptive statistics and the Pearson χ2 test. Results. In our analysis of data on 53 463 graduates, we found that 73% were employed; 15% enrolled in further education; 5% entered a fellowship, internship, residency, volunteer, or service program; and 6% were not employed. Employed graduates went to work in health care (27%), corporations (24%), academia (19%), government (17%), nonprofit (12%), and other sectors (1%). In 2018, 9% of bachelor’s, 4% of master’s, and 2% of doctoral graduates were not employed but seeking employment. Conclusions. Today’s public health graduates are successful in finding employment in various sectors. This new workforce may expand public health’s reach and lead to healthier communities overall. Public Health Implications. With predicted shortages in the governmental public health workforce and expanding hiring because of COVID-19, policymakers need to work to ensure the supply of public health graduates meets the demands of the workforce.
Disrupting the COVID-19 Misinfodemic With Network Interventions: Network Solutions for Network Problems
Authors: Young Lindsay E. , Sidnam-Mauch Emily , Twyman Marlon , Wang Liyuan , Xu Jackie Jingyi , Sargent Matthew , Valente Thomas W. , Ferrara Emilio , Fulk Janet , Monge Peter 
Published: January 2021

Amid the COVID-19 global pandemic, a highly troublesome influx of viral misinformation threatens to exacerbate the crisis through its deleterious effects on public health outcomes and health behavior decisions. This “misinfodemic” has ignited a surge of ongoing research aimed at characterizing its content, identifying its sources, and documenting its effects. Noticeably absent as of yet is a cogent strategy to disrupt misinformation. We start with the premise that the diffusion and persistence of COVID-19 misinformation are networked phenomena that require network interventions. To this end, we propose five classes of social network intervention to provide a roadmap of opportunities for disrupting misinformation dynamics during a global health crisis. Collectively, these strategies identify five distinct yet interdependent features of information environments that present viable opportunities for interventions.
Bone Marrow Aspirate Concentrate Combined with in Situ Forming Bioresorbable Gel Enhances Intervertebral Disc Regeneration in Rabbits
Authors: Ukeba Daisuke , Yamada Katsuhisa , Tsujimoto Takeru , Ura Katsuro , Nonoyama Takayuki , Iwasaki Norimasa , Sudo Hideki 
Published: January 2021

Background:
The current surgical procedure of choice for intervertebral disc (IVD) herniation is discectomy, which induces postoperative IVD degeneration. Thus, cell-based therapies, as a 1-step simple procedure, are desired because of the poor capacity of IVDs for self-repair. The aim of this study was to investigate the repair efficacy of ultra-purified alginate (UPAL) gels containing bone marrow aspirate concentrate (BMAC) for the treatment of discectomy-associated IVD degeneration in rabbits.

Methods:
The mechanical properties of 3 types of gels—UPAL, UPAL containing bone marrow-derived mesenchymal stem cells (BMSCs), and UPAL containing BMAC—were evaluated. Forty rabbits were assigned to 5 groups: intact control, discectomy (to make the cavity), UPAL (implantation of the UPAL gel after discectomy), BMSCs-UPAL (implantation of a combination of autogenic BMSCs and UPAL gel after discectomy), and BMAC-UPAL (implantation of a combination of BMAC and UPAL gel after discectomy). The gels were implanted at 4 weeks after induction of IVD degeneration. At 4 and 12 weeks, magnetic resonance imaging (MRI) as well as histological and immunohistochemical analyses were performed to analyze IVD degeneration qualitatively and the viability of the implanted cells.

Results:
There was no significant difference among the 3 types of gels in terms of the results of unconfined compression tests. The implanted cells survived for 12 weeks. The histological grades of the BMSCs-UPAL (mean and standard deviation, 2.50 ± 0.53; p < 0.001) and BMAC-UPAL (2.75 ± 0.64, p = 0.001) showed them to be more effective in preventing degeneration than UPAL gel alone (3.63 ± 0.52). The effectiveness of BMAC-UPAL was not significantly different from that of BMSCs-UPAL, except with respect to type-II collagen synthesis.

Conclusions:
BMAC-UPAL significantly enhanced the repair of IVD defects created by discectomy. This approach could be an effective therapeutic strategy owing to its simplicity and cost-effectiveness compared with cell therapy using culture-expanded BMSCs.

Clinical Relevance:
Local administration of the BMAC combined with UPAL gel could be an effective therapeutic strategy to enhance IVD repair after discectomy.
An improved high-precision Jacob's staff with laser sighting and topographic capabilities for the high-resolution stratigrapher
Authors: Xu Qiang , Yue Yahui 
Published: January 2021

ABSTRACTAccurate and quick high-resolution measurements of stratigraphic thicknesses and geologic profiles exposed in surface outcrops are critically important for interpreting depositional environments, basin development, and tectonic evolution. Therefore, a high-precision instrument is required for high-resolution stratigraphic measurements. Herein, a new version of the Jacob's staff incorporating an Abney level or a geological compass, a laser pointer, and a handheld GPS is presented. Both the Abney level and the laser pointer are oppositely positioned side by side at the 1.5 m position on the 1.6-m-long fiberglass rod, and they can synchronously slide vertically and rotate horizontally. Because accurate sighting of bedding surfaces is facilitated with both the sighting tube of the Abney level and straight-line beam of the laser pointer, this novel design greatly improves the precision and speed of stratigraphic thickness measurements. More importantly, when the section requires a lateral shift, the straight-line beam can easily and precisely identify the new start point without rotating the rod, which greatly reduces potential changes in the angle of the rod. The GPS unit installed at the top of the rod synchronously records the track of the measured section and coordinates of each measurement, which enables acquisition of a topographic profile along the stratigraphic section. Uncertainties in stratigraphic thickness measurements are minimized when observations are made through the sight tube of the Abney level when the rod is oriented perpendicular to the bedding surface.
Genetic diversity and population structure of Vernonia [Vernonia galamensis (Cass.) Less] populations from Ethiopia revealed by SSR markers
Authors: Egu Alemneh Mideksa , Tesfaye Kassahun , Dagne Kifle , Hu Xuebo 
Published: January 2021

Abstract
Background: Vernonia (Vernonia galamensis) is a potential novel industrial crop due to high demand for its natural epoxidized oil, which can be used for the manufacturing of oleochemicals such as paints, plastic formulations (polyvinyl chloride), and pharmaceutical products. Assessment of the extent of genetic diversity in V. galamensis was the first and the most step in cultivation, breeding and genetic resource conservation. Hence, this study was aimed to assess the genetic diversity and population structure of this plant from different agro-ecologies in Ethiopia using SSR markers. Results: Twenty SSR markers were used for genetic diversity analyses of 150 individual V. galamensis accessions representing 10 populations, from which a total of 79 bands were identified for the 20 loci. All the loci used showed high polymorphism that ranged from 0.50 to 0.96, while the mean observed heterozygosity (Ho) was 0.15 across all the 20 markers evaluated. The molecular variance analysis (AMOVA) showed significant variations among populations which accounted for 11% of the variations. Populations clustering showed that the dendrogram and principal coordinate’s analysis roughly classified the accessions into four groups. However, the Bayesian model-based clustering (STRUCTURE) grouped into 6 (K = 6) major gene pools. Since, the cluster and the STRUCTURE analyses did not group the populations into sharply distinct clusters, due to presence of gene flow and mode of reproduction of the plant. Conclusions: The SSR molecular markers used in this study are highly polymorphic. Among the ten populations, East Showa and East Hararghe revealed higher genetic diversity, signaled that these areas are the hotspots for in-situ conservation of V. galamensis. In addition, the values of SSR markers such as heterozygosity, Shannon‘s index, polymorphic information content, and population clusters are important baseline information for future V. galamensis cultivation, breeding and genetic resource conservation endeavors in Ethiopia.
In silico comparative study of SARS-CoV-2 proteins and antigenic proteins in BCG, OPV, MMR and other vaccines: evidence of a possible putative protective effect
Authors: Haddad-Boubaker Sondes , Othman Houcemeddine , Touati Rabeb , Ayouni Kaouther , Lakhal Marwa , Mustapha Imen Ben , Ghedira Kais , Kharrat Maher , Triki Henda 
Published: January 2021

Abstract
Background: Coronavirus Disease 2019 (COVID-19) is a viral pandemic disease that may induce severe pneumonia in humans. In this paper, we investigated the putative implication of 12 vaccines, including BCG, OPV and MMR in the protection against COVID-19. Sequences of the main antigenic proteins in the investigated vaccines and SARS-CoV-2 proteins were compared to identify similar patterns. The immunogenic effect of identified segments was, then, assessed using a combination of structural and antigenicity prediction tools.Results: A total of 14 highly similar segments were identified in the investigated vaccines. Structural and antigenicity prediction analysis showed that, among the identified patterns, three segments in Hepatitis B, Tetanus, and Measles proteins presented antigenic properties that can induce putative protective effect against COVID-19. Conclusions: Our results suggest a possible protective effect of HBV, Tetanus and Measles vaccines against COVID-19, which may explain the variation of the disease severity among regions.
Coping Response to Workplace Violence Among Healthcare Workers in the Emergency Department: A Qualitative Study
Authors: Salim Noor Hafizah Abdul , Isa Mohd Hisham , Chew Keng Sheng , Noor Mohd Zairul Mohd , Samat Azlan Helmy Abd 
Published: January 2021

Abstract
Background Workplace violence faced in the Emergency Department is well documented. However, there is minimal local data found in the literature. An exploration regarding workplace violence in a local setting is undertaken. This study examined the coping response to the occurrence of workplace violence encountered by an Emergency and Trauma Department healthcare workers. Method The study was done in one of the Emergency and Trauma Department of a tertiary government hospital in Malaysia. A period of a month was taken for data collection. Inclusion criteria includes healthcare workers who had exposure to work- place violence and agreeable to participate in the study. Incident reports were examined and semi-structured in-depth interview of various level of healthcare staff were conducted. Results Three final themes were identified in the way healthcare workers response to workplace violence; First, coping in pre-crisis phase to prevent a violent incident from occurring -mental and behavioural preparedness; Two, coping during crisis to prevent escalation of violence- self-restraint, constructive confrontation, seeking instrumental support; Three, coping after crisis to adapt emotionally and improve knowledge in managing workplace violence-seeking emotional support, disengagement, adaptation. Conclusions The method of coping response employed by participants corresponded to the level of violence exhibited by perpetrator. Multicentre study will help to broaden the understanding of WPV in Malaysia
Establishment and Validation of The Axillary Lymph Node Burden Using Cone-Beam Computerized Tomography and Ultrasound-Based Prediction Models in T1-2 Breast Cancer Patients
Authors: Chen Shen , Li Jiao , Cai Peiqiang , Meng Tiebao , Ma Weimei , Chen Jieting , Xie Chuanmiao , Pei Shengting , Zhou Chunyan , Liu Lizhi , He Ni , Wu Yaopan , Liang Jianye 
Published: January 2021

Abstract
Background: This study aimed to develop and validate models to preoperatively predict the risk of the lymph node (LN) burden based on the Z0011 clinical trial to assist breast cancer surgical decision-making.Methods: Data on 1394 consecutive patients who presented at Sun Yat-sen University Cancer Center for Cone-beam breast computerized tomography (CBBCT) examinations between April 3, 2019, and July 17, 2020, were retrospectively collected. 387 patients who met the inclusion criteria were included and randomly divided into training and validation cohorts. Clinical-pathological information of all patients was recorded, and images were reinterpreted in this study. A bidirectional stepwise method followed by multi-variable analysis was used to incorporate preoperative features and build optimal model sets with the training cohort for prediction of N0 versus N+ and N＜3 versus N≥3.Results: The ROC curves of two models were generated with the training cohort, and their calibration abilities were estimated using 1000 bootstrap resamples. The bias-corrected C-index of the models were 0.779 (95% CI, 0.752–0.793) in model one and 0.809 (95% CI, 0.794–0.833) in model two for the training cohort. Decision curves and clinical impact curves were plotted to evaluate prediction performance for further clinical application. Delong’s test showed comparable performance of both cohorts.Conclusions: Our models were developed as reliable and noninvasive tools for the preoperative prediction of nodal status, and we hope that they can serve as useful tools for the early planning of treatment strategies for breast cancer patients.