bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a new CO2 liquefaction system using the Linde–Hampson process, Kalina power generation unit, and flat plate solar collectors with Al2O3/H2O nanofluid
Authors: Ghorbani Bahram , Khatami Jouybari Alireza 
Published: December 2021

AbstractGreenhouse gas emissions into the atmosphere have had devastating environmental effects, including ozone depletion and global warming. Carbon dioxide (CO2) is widely used in oil and gas plants, the food industry, and as a working fluid in the power industry. Carbon dioxide is liquefied for long‐term storage, to be transported to remote areas, and is used for peak shaving in the power plants. Solar flat plate collectors and wasted heat from the CO2 liquefaction system can be used in power plant systems. Also, the use of nanoparticles in the collectors improves the thermal properties of the working fluid and increases the efficiency of solar collectors. This study has developed a new hybrid system for CO2 liquefaction using Linde–Hampson system, Kalina power generation unit, and flat plate solar collectors. The Linde–Hampson system's dissipated heat and solar collectors are used to supplying part of the power of the CO2 liquefaction system. The combined system produces 9416 kmol/h of liquid CO2 by absorbing 35.97 MW of power. The Kalina power generation unit provides 9.546 MW of power by absorbing 76.98 MW of the CO2 liquefaction cycle's dissipated heat and 91.18 MW from flat plate collectors. Based on the output of exergy assessment, exergy efficiency and exergy degradation of the developed integrated structure are 44.16% and 118.3 MW, respectively. Moreover, significant portions of exergy destruction in the combined process belong to solar collectors (74.68%), heat exchangers (12.47%), and compressors (7.157%), respectively. The use of Al2O3 nanoparticles in pure water has been investigated for heat transfer in flat panel solar collectors. According to the sensitivity analysis results, as the volume ratio of particles in nanofluid increases to 6%, the production capacity of the Kalina cycle and exergy efficiency improves to 9.56 MW and 9.522%, respectively. Also, as the pressure of the pumped fluid in the Kalina cycle increases from 800 to 1600 kPa, the exergy yield of the Kalina cycle and the exergy yield of the whole combined system increase to 36.34% and 44.26%, respectively.
COVID‐19 and access to cancer care in Kenya: patient perspective
Authors: Umar Shahid , Chybisov Andriy , McComb Kristie , Nyongesa Catherine , Mugo‐Sitati Christine , Bosire Anastacia , Muya Charles , Leach Corinne R. 
Published: December 2021

AbstractCOVID‐19 disruptions severely impacted access to health services for noncommunicable diseases, including cancer, but few studies have examined patient perspectives of COVID‐19‐induced barriers to care in low/middle‐income countries. Data come from a survey completed online, over the phone or in person of 284 adult people with cancer in Kenya. One‐third (36%) of participants had primary or no education and 34% had some or complete secondary education. Half of the participants (49%) were aged 40 to 59, 21% were 18 to 39 and 23% were 60 or older. Two‐thirds were female (65%) and most visited a national referral hospital in Nairobi to receive care (84%). Mean travel time to Nairobi from the respondent county of residence was 2.47 hours (±2.73). Most participants reported decreased household income (88%) and were worried about their ability to afford cancer treatment due to COVID‐19 (79%). After covariate adjustment, participants who lost access to hospitals due to COVID‐19 travel restrictions were 15 times more likely to experience a cancer care delay (OR = 14.90, 95% CI: 7.44‐29.85) compared to those with continued access to hospitals. Every additional hour of travel time to Nairobi from their county of residence resulted in a 20% increase in the odds of a cancer care delay (OR = 1.20, 95% CI: 1.06‐1.36). Transportation needs and uninterrupted access to cancer care and medicines should be accounted for in COVID‐19 mitigation strategies. These strategies include permits for cancer patients and caregivers to travel past curfew time or through block posts to receive care during lockdowns, cash assistance and involving patient navigators to improve patient communication.
mdm2 gene amplification is associated with luminal breast cancer progression in humanized PDX mice and a worse outcome of estrogen receptor positive disease
Authors: Wege Anja Kathrin , Rom‐Jurek Eva‐Maria , Jank Paul , Denkert Carsten , Ugocsai Peter , Solbach Christine , Blohmer Jens‐Uwe , Sinn Bruno , van Mackelenbergh Marion , Möbus Volker , Trumpp Andreas , Marangoni Elisabetta , Pfarr Nicole , Irlbeck Christoph , Warfsmann Jens , Polzer Bernhard , Weber Florian , Ortmann Olaf , Loibl Sibylle , Vladimirova Valentina , Brockhoff Gero 
Published: December 2021

AbstractEstrogen receptor‐positive breast cancer is a highly prevalent but heterogeneous disease among women. Advanced molecular stratification is required to enable individually most efficient treatments based on relevant prognostic and predictive biomarkers. First objective of our study was the hypothesis‐driven discovery of biomarkers involved in tumor progression upon xenotransplantation of Luminal breast cancer into humanized mice. The second objective was the marker validation and correlation with the clinical outcome of Luminal breast cancer disease within the GeparTrio trial. An elevated mdm2 gene copy number was associated with enhanced tumor growth and lung metastasis in humanized tumor mice. The viability, proliferation and migration capacity of inherently mdm2 positive breast cancer cells in vitro were significantly reduced upon mdm2 knockdown or anti‐mdm2 targeting. An mdm2 gain significantly correlated with a worse DFS and OS of Luminal breast cancer patients, albeit it was also associated with an enhanced preoperative pathological response rate. We provide evidence for an enhanced Luminal breast cancer stratification based on mdm2. Moreover, mdm2 can potentially be utilized as a therapeutic target in the Luminal subtype.
Phosphorus‐nitrogen compounds part 59. The syntheses of tetrachloro and tetraamino‐2‐pyridylmethylspiro(N/N)ethylenediaminocyclotriphosphazenes: Structural characterization, bioactivity, and molecular docking studies
Authors: Bozkurt Bilge , Elmas Gamze , Yakut Mehtap , Okumuş Aytuğ , Çerçi Nebahat Aytuna , Zeyrek Celal Tuğrul , Kılıç Zeynel , Açık Leyla , Hökelek Tuncer 
Published: December 2021

AbstractIn this study, primarily, tetrachloro‐2‐pyridylmethylspiro‐N/N‐ethylenediamino‐cyclotriphosphazenes (4 and 5) were prepared from the reactions of equimolar amounts of N‐alkyl‐N′‐2‐pyridylmethylethylenediamines, [PyCH2NH(CH2)2NHR (R:CH3, 2 and R:C2H5, 3)], and hexachlorocyclotriphosphazene [(HCCP, trimer), N3P3Cl6 (1)]. Compounds 4 and 5 react with secondary amines to yield the fully substituted tetraamino‐2‐pyridylmethylspiro‐N/N‐ethylenediamino‐cyclotriphosphazenes (4a–5c) in dry THF, respectively. These derivatives were obtained by both conventional and microwave‐assisted reactions, and their yields were compared. In addition, it should also be noted that these cyclotriphosphazenes were obtained for use in the investigation of their spectral, crystallographic, antimicrobial, and anticancer properties. The structures of the compounds were elucidated by spectral data. The crystal structures of 4, 5a, and 5c were clarified by the single crystal X‐ray diffraction technique. Antibacterial activities and biofilm preventions of 4a–c and 5a–c against bacteria, and their antifungal activities against fungi were investigated. According to broth microdilution method, the results showed that all compounds were highly effective against C. albicans. The interactions of these compounds with DNA and their cytotoxic activities against L929 fibroblast and A549 lung cancer cell lines were investigated. In addition, Density Functional Theory (DFT) calculations of 4, 5a, and 5c were made, and molecular docking studies with DNA and cytochrome P450 enzyme were presented.
The effect of casirivimab with imdevimab on disease progression in nonsevere COVID‐19 patients in a single hospital in Japan
Authors: Komagamine Junpei , Yabuki Taku , Yoshihara Satsuki , Tanaka Nao 
Published: December 2021

AbstractBackgroundRecent randomized trials have revealed that neutralizing monoclonal antibodies can reduce disease progression in mild–moderate COVID‐19 patients. However, no studies have investigated the effect of neutralizing monoclonal antibodies on clinical outcomes in Japan.MethodsA single‐center retrospective and prospective cohort study was conducted. All consecutive febrile nonsevere COVID‐19 patients with at least one risk factor were included. The primary outcome was progression to severe COVID‐19. Severe COVID‐19 cases were defined as patients requiring oxygen therapy and dexamethasone. The differences in the primary outcomes between the patients who were treated with casirivimab with imdevimab (treatment group) and those who were not (control group) were compared using the chi‐squared test.ResultsA total of 128 patients were included. Of those, the mean age was 53.6 years old (SD 9.9), and 52 (40.6%) were women. Fifty‐three patients were treated with casirivimab with imdevimab, and 75 patients were given the standard treatment only. The primary outcome occurred in eight (15.1%) of the 53 patients in the treatment group and 33 (44.0%) of the 75 patients in the control group (odd ratio [OR] 0.23, 95% CI 0.09 to 0.55). The multivariate analysis revealed that the use of casirivimab with imdevimab (OR 0.21, 95% CI 0.08 to 0.54) was the only independent risk factor associated with progression to severe COVID‐19. No patients died during hospitalization in either group.ConclusionSimilar to other countries, casirivimab with imdevimab significantly reduced disease progression in early nonsevere COVID‐19 patients with fever and risk factors in Japan.
Can augmented reality satisfy consumers' need for touch?
Authors: Gatter Shirin , Hüttl‐Maack Verena , Rauschnabel Philipp A. 
Published: December 2021

AbstractConsumers with a high autotelic need for touch tend to experience deprivation because they cannot touch products while shopping online. Augmented reality (AR) in retail allows consumers to explore products virtually as if they were present in the physical environment, except the fact that they are not touchable. This study investigates whether AR can compensate for this lack of touch or whether, on the contrary, these consumers are skeptical because they crave even more real haptic input. The results of four studies consistently show that consumers' autotelic need for touch is associated with benefits that positively impact various managerially relevant outcomes such as store and product attitudes or purchase intentions. However, the results also point to differences between expected and experienced hedonic and utilitarian benefits along the customer journey. Hedonic benefits prevail when consumers with a high need for touch actually experience AR, while they instead expect utilitarian benefits. The findings contribute to the AR marketing and online retailing literature by demonstrating that AR features can mimic touchable features of products. They also highlight the practical benefits of AR as a powerful tool in digital marketing.
A new phosphorus flame‐retard curing agent for epoxy resin/anhydride system
Authors: Han Yichen , Zhao Hui , Chen Jichuan , Wang Xinlong , Chen Lixin , Ran Di , Wang Zhenyu , Zeng Panjin 
Published: December 2021

AbstractA new phosphorus containing anhydride (DPO‐MA) curing agent is successfully synthesized via the addition reaction between diphenylphosphinoxid (DPO) and maleic anhydride (MA). It can improve the flame retardancy of epoxy resin (EP) without significantly deteriorating its mechanical properties. Due to the high efficiency of the gas phase flame‐retard mechanism, only 1.0 wt% of phosphorus is sufficient to increase the LOI value to 33.1% and UL‐94 to V0 rating. Cone calorimetry data shows that the peak of heat release decreases more than 42% than that of neat EP during combustion. Besides, the rigid DPO skeleton in the molecular chain can greatly improve the Tg value of the DPO‐MA/EP‐1.0, which is as high as 125°C, much higher than that of neat EP. Thus, this work exhibits a great potential value for EP materials.
Quantitative features to assist in the diagnostic assessment of chronic lymphocytic leukemia progression†
Authors: Merino Anna , Rodellar José 
Published: December 2021

AbstractThe use of artificial intelligence methods in the image‐based diagnostic assessment of hematological diseases is a growing trend in recent years. In these methods, the selection of quantitative features that describe cytological characteristics plays a key role. They are expected to add objectivity and consistency among observers to the geometric, color, or texture variables that pathologists usually interpret from visual inspection. In a recent paper in The Journal of Pathology, El Hussein, Chen et al proposed an algorithmic procedure to assist pathologists in the diagnostic evaluation of chronic lymphocytic leukemia (CLL) progression using whole‐slide image analysis of tissue samples. The core of the procedure was a set of quantitative descriptors (biomarkers) calculated from the segmentation of cell nuclei, which was performed using a convolutional neural network. These biomarkers were based on clinical practice and easily calculated with reproducible tools. They were used as input to a machine learning algorithm that provided classification in one of the stages of CLL progression. Works like this can contribute to the integration into the workflow of clinical laboratories of automated diagnostic systems based on the morphological analysis of histological slides and blood smears. © 2021 The Pathological Society of Great Britain and Ireland.
Deciphering the fluorescence quenching mechanism of a flavonoid drug following interaction with human hemoglobin
Authors: Sett Riya , Paul Bijan K. , Guchhait Nikhil 
Published: December 2021

AbstractThe present work demonstrates comprehensive spectrofluorometric characterization of interaction of a bioactive flavonoid quercetin (QCT) with the transport protein human hemoglobin (Hb) by protein‐induced quenching phenomenon. Interaction between such a pharmacologically essential drug and Hb has been enlightened by means of steady‐state and time‐resolved fluorescence spectroscopy. The protein‐induced Stern–Volmer quenching study of QCT depicts an upward curvature that cannot be an outcome of only the static quenching arising from ground‐state complexation. Therefore, an extensive time‐resolved fluorescence characterization of the quenching process has been performed to discern the actuating quenching mechanism. However, the estimated value of bimolecular quenching constant (kq) from the diffusion‐controlled quenching study hints for dynamic quenching phenomenon. Finally, the significant amplification of the average lifetime of QCT as a function of protein concentration aids to resolve this conflict affirming the quenching phenomenon to be an exquisite drug–protein binding interaction. Not only the quenching mechanism has been established, but also the binding parameters and location of binding within the microheterogeneous cavity of Hb has been explicated. AutoDock‐based “blind docking” simulation has been employed to conquer probable binding location of the drug within protein cavity. Nevertheless, circular dichroism (CD) spectroscopy depicts the modification of the native conformation of Hb, which is indicative of this binding phenomenon.
Differentiation of leucine and isoleucine residues in peptides using charge transfer dissociation mass spectrometry (CTD‐MS)
Authors: Edwards Halle M. , Wu Hoi‐Ting , Julian Ryan R. , Jackson Glen P. 
Published: December 2021

RationaleThe function of a protein or the binding affinity of an antibody can be substantially altered by the replacement of leucine (Leu) with isoleucine (Ile), and vice versa, so the ability to identify the correct isomer using mass spectrometry can help resolve important biological questions. Tandem mass spectrometry approaches for Leu/Ile (Xle) discrimination have been developed, but they all have certain limitations.MethodsFour model peptides and two wild‐type peptide sequences containing either Leu or Ile residues were subjected to charge transfer dissociation (CTD) mass spectrometry on a modified three‐dimensional ion trap. The peptides were analyzed in both the 1+ and 2+ charge states, and the results were compared to conventional collision‐induced dissociation spectra of the same peptides obtained using the same instrument.ResultsCTD resulted in 100% sequence coverage for each of the studied peptides and provided a variety of side‐chain cleavages, including d, w and v ions. Using CTD, reliable d and w ions of Xle residues were observed more than 80% of the time. When present, d ions are typically greater than 10% of the abundance of the corresponding a ions from which they derive, and w ions are typically more abundant than the z ions from which they derive.ConclusionsCTD has the benefit of being applicable to both 1+ and 2+ precursor ions, and the overall performance is comparable to that of other high‐energy activation techniques like hot electron capture dissociation and UV photodissociation. CTD does not require chemical modifications of the precursor peptides, nor does it require additional levels of isolation and fragmentation.
Demarcating transdisciplinary research in sustainability science—Five clusters of research modes based on evidence from 59 research projects
Authors: Jahn Stephanie , Newig Jens , Lang Daniel J. , Kahle Judith , Bergmann Matthias 
Published: December 2021

AbstractThe discourse revolving around “new modes of knowledge production”—particularly in sustainability‐oriented research—seems to suggest a duality of transdisciplinary versus non‐transdisciplinary research. Yet, in reality, a spectrum of transdisciplinary research modes may be expected. This article offers an empirically grounded distinction of five research modes, based on a cluster analysis of 59 completed sustainability‐oriented research projects. Projects in one cluster approximate a transdisciplinary ideal type, while another cluster combines almost purely practice‐oriented projects. Among the three remaining clusters with varying degrees of practitioner interaction, one cluster assembles projects with strictly academic research, while realizing substantial societal impact. Furthermore, our analyses indicate that the choice of research mode strongly depends on the funding context, with mission‐oriented funding encouraging more collaborative modes. Overall, clusters with more practitioner interaction display stronger societal outputs and impacts at the cost of academic outputs and impacts. Beyond the demarcation of transdisciplinary research modes in sustainability science, our empirical analysis revealed three important tensions related to the theory and practice of this research approach: the duality of science and society (and scholars and practitioners); imbalances in the involvement and influence of different societal actor groups; and tensions between societal and academic outputs and impacts.
The Evolution of the Charge Transport Mechanism in Single‐Molecule Break Junctions Revealed by Flicker Noise Analysis
Authors: Pan Zhichao , Chen Lichuan , Tang Chun , Hu Yong , Yuan Saisai , Gao Tengyang , Shi Jie , Shi Jia , Yang Yang , Hong Wenjing 
Published: December 2021

AbstractThe electronic noise characterization of single‐molecule devices provides insights into the mechanisms of charge transport. In this work, it is reported that flicker noise can serve as an indicator of the time‐dependent evolution of charge transport mechanisms in the single‐molecule break junction process. By introducing time‐frequency analysis, the authors find that flicker noise components of the molecule junction show time evolution behavior in the dynamic break junction process. A further investigation of the power‐law dependence of flicker with conductance during the dynamic break junction process reveals that the mechanism of charge transport transits from the through‐space transport to the through‐bond transport, and is dominated by through‐space transport again when the junction is about to rupture. The authors’ results provide a flicker noise‐based way to characterize the time‐dependent evolution of charge transport mechanisms in single‐molecule break junctions.
Phylogenomic analysis confirms polyphyly of Leptospermum and delineates five major clades that warrant generic recognition
Authors: Binks Rachel M. , Heslewood Margaret , Wilson Peter G. , Byrne Margaret 
Published: December 2021

AbstractLeptospermum is an ecologically and economically important genus with a long unresolved taxonomic issue concerning polyphyly, as indicated from early molecular analysis on two chloroplast regions. To resolve this, we used genome skimming to obtain high‐copy chloroplast and nuclear ribosomal DNA for a comprehensive phylogenomic analysis of 110 accessions comprising of 38 Leptospermum taxa, 6 closely allied genera and 5 outgroup genera. Maximum likelihood and Bayesian analyses resolved congruent clades for the chloroplast (132,143 bp: 80 CDSs, 4 rRNA genes, 29 tRNA genes, 17 introns and 97 IGSs) and nuclear (1219 bp: ITS1, ITS2, ETS, 5.8S) alignments to provide a robust interpretation of evolutionary relationships. Together, these data confirmed extensive polyphyly of Leptospermum that separated the genus into five monophyletic clades spread amongst clades representing six closely allied genera: Agonis, Asteromyrtus, Homalospermum, Kunzea, Neofabricia and Pericalymma. These five Leptospermum clades share some similarities with morphological and genetic groupings identified previously but provide greater resolution to inform a clear pathway to taxonomic revision. The evidence presented here provides support for resolution of the current polyphyly of Leptospermum through the recognition of five genera, while retaining all other genera of Leptospermeae in their current circumscription.
A high-protein total diet replacement alters the regulation of food intake and energy homeostasis in healthy, normal-weight adults
Authors: Oliveira Camila L. P. , Boulé Normand G. , Elliott Sarah A. , Sharma Arya M. , Siervo Mario , Berg Aloys , Ghosh Sunita , Prado Carla M. 
Published: December 2021

Abstract
Purpose
Dietary intake can affect energy homeostasis and influence body weight control. The aim of this study was to compare the impact of high-protein total diet replacement (HP-TDR) versus a control (CON) diet in the regulation of food intake and energy homeostasis in healthy, normal-weight adults.

Methods
In this acute randomized controlled, cross-over study, participants completed two isocaloric arms: a) HP-TDR: 35% carbohydrate, 40% protein, and 25% fat; b) CON: 55% carbohydrate, 15% protein, and 30% fat. The diets were provided for 32 h while inside a whole-body calorimetry unit. Appetite sensations, appetite-related hormones, and energy metabolism were assessed.

Results
Forty-three healthy, normal-weight adults (19 females) participated. Appetite sensations did not differ between diets (all p > 0.05). Compared to the CON diet, the change in fasting blood markers during the HP-TDR intervention was smaller for peptide tyrosine-tyrosine (PYY; − 18.9 ± 7.9 pg/mL, p = 0.02) and greater for leptin (1859 ± 652 pg/mL, p = 0.007). Moreover, postprandial levels of glucagon-like peptide 1 (1.62 ± 0.36 pM, p < 0.001) and PYY (31.37 ± 8.05 pg/mL, p < 0.001) were higher in the HP-TDR. Significant correlations were observed between energy balance and satiety (r = − 0.41, p = 0.007), and energy balance and PFC (r = 0.33, p = 0.033) in the HP-TDR.

Conclusion
Compared to the CON diet, the HP-TDR increased blood levels of anorexigenic hormones. Moreover, females and males responded differently to the intervention in terms of appetite sensations and appetite-related hormones.

Trial registration
NCT02811276 (retrospectively registered on 16 June 2016) and NCT03565510 (retrospectively registered on 11 June 2018).