bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nilai-Nilai Publik dalam Kebijakan Pelestarian Cendana (Santalum Album L) di Kabupaten Timor Tengah Selatan
Authors: Nursalam Nursalam 
Published: October 2021

Nilai-nilai publik adalah nilai yang memberikan konsensus normatif tentang: hak, manfaat, dan hak prerogatif; kewajiban warga negara kepada masyarakat, negara, dan satu sama lain; serta prinsip-prinsip yang menjadi landasan pemerintah dan kebijakan (Bozeman: 2007). nilai publik sebagai cara untuk memahami aktivitas pemerintah, menginformasikan pembuatan kebijakan dan membangun penyampaian layanan (O’Flynn, 2007)
Penelitian ini bertujuan untuk mengetahui penerapan nilai-nilai publik dalam kebijakan pelestarian Cendana (santalum album L) di kabupaten Timor Tengah Selatan. Metode yang digunakan adalah metode penelitian kualitatif dengan teknik pengumpulan data melalui wawancara, observasi, dan dokumentasi. Pemilihan informan ditetapkan dengan menggunakan teknik purposif kepada tokoh-tokoh masyarakat sebagai pemangku kepentingan adat, pengambil kebijakan dan pelaksana kebijakan.
Hasil penelitian menunjukkan bahwa nilai publik sangat penting dijadikan sebagai landasan dalam proses perumusan dan pelaksanaan kebijakan pelestarian Cendana. Nilai-nilai seperti nilai keadilan sosial, akuntabiltas, dan nilai keberlanjutan, belum maksimal diakomodir pada kebijakan pelestarian Cendana. Beberapa implikasi yang muncul akibat terabaikannya nilai adalah; masyarakat (publik) tidak mempunyai semangat untuk ikut terlibat dalam upaya pelestarian dan masih adanya pandangan bahwa Cendana sebagai sumber daya alam lokal yang bernilai tinggi, namun menuai juga banyak masalah.
Rekomendasi penelitian adalah perlunya revitalisasi nilai-nilai publik (public values) agar kebijakan pelestarian dapat meningkatkan populasi cendana.
Outcome Comparison Between Open and Endovascular Aortic Repair for Retrograde Type A Intramural Hematoma With Intimal Tear in the Descending Thoracic Aorta: A Retrospective Observational Study
Authors: Yang Kelvin Jeason , Chi Nai-Hsin , Yu Hsi-Yu , Chen Yih-Sharng , Wang Shoei-Shen , Wu I-Hui 
Published: October 2021

Objective: The optimal treatment modality for retrograde type A intramural hematoma (IMH) remains debatable. This study evaluated and compared surgical outcomes and aortic remodeling after open aortic repair and thoracic endovascular aortic repair (TEVAR) in patients with retrograde type A IMH with a primary intimal tear or ulcer like projection in the descending aorta.Methods: A single center, retrospective observational study was performed on patients with retrograde type A IMH undergoing either open aortic repair and TEVAR. From June 2009 and November 2019, 46 patients with retrograde type A IMH who received either open aortic repair or TEVAR at our institution were reviewed for clinical outcomes, including post-operative mortality/morbidity, re-intervention rate and aortic remodeling.Results: 33 patients underwent open aortic repair and 13 underwent TEVAR. Median age was 68 years (interquartile range [IQR] 15.2 years) and 63 years (IQR 22.5 years) for the open repair group and TEVAR group, respectively. The median duration of follow-up for TEVAR patients was 37.6 months and 40.3 months for open aortic repair. No difference in the 5-year estimated freedom from all-cause mortality (82.1 vs. 87.8%, p = 0.34), re-intervention (82.5 vs. 93.8%, p = 0.08), and aortic-related mortality (88.9 vs. 90.9%, p = 0.88) were observed between the TEVAR and open repair group, respectively; however, the open repair group had a significantly higher 30-day composite morbidity (39.4 vs. 7.7%, p = 0.037). All patients from both treatment groups had complete resolution of the IMH in the ascending aorta. With regard to the descending thoracic aorta, TEVAR group had a significantly greater regression in the diameter of the false lumen or IMH thickness when compared to the open repair group [median 14mm (IQR 10.1) vs. 5mm (IQR 9.5), p &lt; 0.001].Conclusion: TEVAR and open aortic repair were both effective treatments for retrograde type A IMH, in which no residual ascending aortic IMH was observed during follow-up. TEVAR was also associated with lower post-operative composite morbidities and better descending aortic remodeling. In selected patients with retrograde type A IMH, TEVAR might be a safe, effective alternative treatment modality.
A Comparative Transcriptional Landscape of Two Castor Cultivars Obtained by Single-Molecule Sequencing Comparative Analysis
Authors: Zhou Yaxing , Zhu Guoli , Wang Yun , He Zhibiao , Zhou Wei 
Published: October 2021

Background and Objectives: Castor (Ricinus communis L.) is an important non-edible oilseed crop. Lm-type female strains and normal amphiprotic strains are important castor cultivars, and are mainly different in their inflorescence structures and leaf shapes. To better understand the mechanisms underlying these differences at the molecular level, we performed a comparative transcriptional analysis.Materials and Methods: Full-length transcriptome sequencing and short-read RNA sequencing were employed.Results: A total of 76,068 and 44,223 non-redundant transcripts were obtained from high-quality transcripts of Lm-type female strains and normal amphiprotic strains, respectively. In Lm-type female strains and normal amphiprotic strains, 51,613 and 20,152 alternative splicing events were found, respectively. There were 13,239 transcription factors identified from the full-length transcriptomes. Comparative analysis showed a great variety of gene expression of common and unique transcription factors between the two cultivars. Meanwhile, a functional analysis of the isoforms was conducted. The full-length sequences were used as a reference genome, and a short-read RNA sequencing analysis was performed to conduct differential gene analysis. Furthermore, the function of DEGs were performed to annotation analysis.Conclusion: The results revealed considerable differences and expression diversity between the two cultivars, well beyond what was reported in previous studies and likely reflecting the differences in architecture between these two cultivars.
Development of a 3 RNA Binding Protein Signature for Predicting Prognosis and Treatment Response for Glioblastoma Multiforme
Authors: Sun Ruohan , Pan Yujun , Mu Long , Ma Yaguang , Shen Hong , Long Yu 
Published: October 2021

Purpose: Glioblastoma multiforme (GBM) is the most widely occurring brain malignancy. It is modulated by a variety of genes, and patients with GBM have a low survival ratio and an unsatisfactory treatment effect. The irregular regulation of RNA binding proteins (RBPs) is implicated in several malignant neoplasms and reported to exhibit an association with the occurrence and development of carcinoma. Thus, it is necessary to build a stable, multi-RBPs signature-originated model for GBM prognosis and treatment response prediction.Methods: Differentially expressed RBPs (DERBPs) were screened out based on the RBPs data of GBM and normal brain tissues from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression Program (GTEx) datasets. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses on DERBPs were performed, followed by an analysis of the Protein-Protein Interaction network. Survival analysis of the DERBPs was conducted by univariate and multivariate Cox regression. Then, a risk score model was created on the basis of the gene signatures in various survival-associated RBPs, and its prognostic and predictive values were evaluated through Kaplan-Meier analysis and log-rank test. A nomogram on the basis of the hub RBPs signature was applied to estimate GBM patients’ survival rates. Moreover, western blot was for the detection of the proteins.Results: BICC1, GNL3L, and KHDRBS2 were considered as prognosis-associated hub RBPs and then were applied in the construction of a prognostic model. Poor survival results appeared in GBM patients with a high-risk score. The area under the time-dependent ROC curve of the prognostic model was 0.723 in TCGA and 0.707 in Chinese Glioma Genome Atlas (CGGA) cohorts, indicating a good prognostic model. What was more, the survival duration of the high-risk group receiving radiotherapy or temozolomide chemotherapy was shorter than that of the low-risk group. The nomogram showed a great discriminating capacity for GBM, and western blot experiments demonstrated that the proteins of these 3 RBPs had different expressions in GBM cells.Conclusion: The identified 3 hub RBPs-derived risk score is effective in the prediction of GBM prognosis and treatment response, and benefits to the treatment of GBM patients.
Anti-gout Medications and Risk of Cardiovascular Disease: A Nested Case-Control Study
Authors: Chuang Tsung-Ju , Wang Yu-Hsun , Wei James Cheng-Chung , Yeh Chih-Jung 
Published: October 2021

Introduction: Gout is the leading cause of inflammatory arthritis and is also correlated with multiple comorbidities, including cardiovascular disease (CVD), whose future risk can be lowered by urate-lowering therapy (ULT) in gout patients. It is, however, still not clear whether its effect is associated with the days of usage and the adherence rate of ULT.Methods: Data were collected from Taiwan's National Health Insurance Research Database. The study period was from 1999/1/1 to 2013/12/31. In addition, patients with newly diagnosed gout from 2000 to 2012 and usage of antigout preparations (allopurinol or benzbromarone) within half a year among age ≥20 years old were enrolled in the study. The outcome of interest is CVD. New diagnosis of CVD after half a year of diagnosis of gout was included in the CVD group. Moreover, conditional logistic regression was used to evaluate the odds ratio of CVD in relation to the days of usage and to the adherence rate of ULT after the adjustment for potentially confounding variables.Results: A total of 3,706 gout patients with and without CVD have been included in the final analysis after a 1:1 propensity score that matched for age, sex, comorbidities, aspirin, and statin. The days of usage of allopurinol was &lt;180 days and benzbromarone, in its turn, presupposed a higher risk of CVD. The adherence rate of allopurinol and benzbromarone at ≥ 0.7 both have a lower CVD risk: allopurinol (adjusted OR: 0.66 95% CI: 0.46–0.96), benzbromarone (adjusted OR: 0.68 95% CI: 0.50–0.91). The subgroup analysis revealed an adherence rate of ≥0.7 of ULT with a lower CVD was only found to be present in males and at age &lt;65. Furthermore, the correlations were more pronounced in the ischemic heart disease subgroup than in the cerebrovascular disease group.Conclusion: This study reveals that gout patients taking ULT (allopurinol and benzbromarone) with an adherence rate of ≥0.7 are at a lower risk of developing CVD, especially with a younger age (&lt;65) and if they are male. On top of this, the benefit is more pronounced in ischemic heart disease. Despite further prospective trials needing to be warranted to confirm our findings, health care providers may, bearing these conclusions in mind, emphasize the importance of adherence to ULT in gout patients.
Theta and Alpha Oscillatory Activity During Working Memory Maintenance in Long-Term Cannabis Users: The Importance of the Polydrug Use Context
Authors: Binkowska Alicja Anna , Jakubowska Natalia , Krystecka Klaudia , Galant Natalia , Piotrowska-Cyplik Agnieszka , Brzezicka Aneta 
Published: October 2021

Background: Impairments in various subdomains of memory have been associated with chronic cannabis use, but less is known about their neural underpinnings, especially in the domain of the brain’s oscillatory activity.Aims: To investigate neural oscillatory activity supporting working memory (WM) in regular cannabis users and non-using controls. We focused our analyses on frontal midline theta and posterior alpha asymmetry as oscillatory fingerprints for the WM’s maintenance process.Methods: 30 non-using controls (CG) and 57 regular cannabis users—27 exclusive cannabis users (CU) and 30 polydrug cannabis users (PU) completed a Sternberg modified WM task with a concurrent electroencephalography recording. Theta, alpha and beta frequency bands were examined during WM maintenance.Results: When compared to non-using controls, the PU group displayed increased frontal midline theta (FMT) power during WM maintenance, which was positively correlated with RT. The posterior alpha asymmetry during the maintenance phase, on the other hand, was negatively correlated with RT in the CU group. WM performance did not differ between groups.Conclusions: Both groups of cannabis users (CU and PU), when compared to the control group, displayed differences in oscillatory activity during WM maintenance, unique for each group (in CU posterior alpha and in PU FMT correlated with performance). We interpret those differences as a reflection of compensatory strategies, as there were no differences between groups in task performance. Understanding the psychophysiological processes in regular cannabis users may provide insight on how chronic use may affect neural networks underlying cognitive processes, however, a polydrug use context (i.e., combining cannabis with other illegal substances) seems to be an important factor.
Long-Term Use of Statins Lowering the Risk of Rehospitalization Caused by Ischemic Stroke Among Middle-Aged Hyperlipidemic Patients: A Population-Based Study
Authors: Yin Jiu-Haw , Peng Giia-Sheun , Chen Kang-Hua , Chu Chi-Ming , Chien Wu-Chien , Kao Li-Ting , Wu Chia-Chao , Yang Chih-Wei , Tsai Wen-Chiuan , Lin Wei-Zhi , Wu Yi-Syuan , Lin Hung-Che , Chang Yu-Tien 
Published: October 2021

Background: The long-term effects of statin use on rehospitalization due to ischemic stroke (reHospIS) in hyperlipidemic patients are still unknown. Therefore, we aimed to assess the long-term risks of reHospIS for hyperlipidemic patients who were taking statins and nonstatin lipid-lowering medicines on a regular basis.Methods and Materials: The National Health Insurance Research Database in Taiwan was used to conduct a 6-year cohort study of patients &gt;45 years old (n = 9,098) who were newly diagnosed with hyperlipidemia and hospitalized for the first or second time due to ischemic stroke (IS). The risk of reHospIS was assessed using Cox proportional hazards regression model.Results: Nonstatin lipid-lowering medicines regular users were associated with a higher risk of reHospIS compared to stains users (hazard ratio, HR = 1.29–1.39, p &lt; 0.05). Rosuvastatin was the most preferred lipid-lowering medicine with lower HRs of reHospIS in hyperlipidemic patients whether they developed diabetes or not. Bezafibrate regular users of hyperlipidemic patients developing diabetes (HR = 2.15, p &lt; 0.01) had nearly 50% lower reHospIS risks than those without diabetes (HR = 4.27, p &lt; 0.05). Age, gender, drug dosage, comorbidities of diabetes and heart failure (HF), and characteristics of the first hospitalization due to IS were all adjusted in models. Moreover, increasing trends of HRs of reHospIS were observed from Rosuvastatin, nonstatin lipid-lowering medicines, Lovastatin, and Gemfibrozil to Bezafibrate users.Conclusion: Statins were associated with long-term secondary prevention of reHospIS for hyperlipidemic patients. Rosuvastatin seemed to have the best protective effects. On the other hand, Bezafibrate appears to be beneficial for hyperlipidemic patients developing diabetes. Further research into the combination treatment of statin and nonstatin lipid-lowering medicines in hyperlipidemic patients developing diabetes is warranted.
Explore the Bereavement Needs of Families of Children With Cancer From the Perspective of Health Caregivers: A Qualitative Study
Authors: Pakseresht Maryam , Rassouli Maryam , Rejeh Nahid , Rostami Shahnaz , Barasteh Salman , Molavynejad Shahram 
Published: October 2021

Introduction: The experience of bereavement is associated with severe physical, psychological, social and spiritual reactions in the parents of children with cancer. Because of that, the families of these children need to receive bereavement services. The aim of this study was to explore the bereavement needs of families of children with cancer from the perspective of health caregiver as people who have a close relationship with the child and the family.Methods: This qualitative descriptive study design in. In total 15 semi-structured interviews were conducted using a purposive sampling in 2018. Interviews were recorded and transcribed and conventional content analysis was used to analysis the data. The Trustworthiness of the data were assessed according to the criteria of Lincoln and Guba.Results: From the data analysis, needs of the bereaved family were categorized in three dimension including “achieving peace,” “Abandoned family access to care,” and “continuing care.” The category of “achieving peace” includes spiritual and existential support, companionship with the family, contact with other bereaved families, support in passing and accepting the bereaved and continuing empathetic communication with the family, the category “Abandoned family access to care” includes the promotion of family self-control, awareness of end-of-life care to the family, and the category of “continuing care,” includes formal and informal family care and individualized care.Conclusion: It is necessary for the care team to pay special focus to family considering the needs of the family about the death of the patient and the challenges of the family bereavement period. It is recommended that members of the health care team should be trained in assessing family needs, identifying risks of adverse outcomes, continuing care, and providing resources during bereavement. The needs of the bereaved family should also be addressed in their care plan.
The Design and Rationale of a Multicentre Randomised Controlled Trial Comparing Transperineal Percutaneous Laser Ablation With Transurethral Resection of the Prostate for Treating Benign Prostatic Hyperplasia
Authors: Zhang Wei , Zhang Weituo , Guo Qian , Chen Lei , Meng Zheying , Xu Yanjun , Cao Nailong , Hu Bing , Qian Biyun 
Published: October 2021

Background: Transurethral resection of the prostate (TURP) is regarded as the “gold standard” for the treatment of benign prostatic hyperplasia (BPH) in elderly men. However, ~15% of patients who had undergone TURP had intraoperative and postoperative complications, such as bleeding, urinary incontinence and urethral stricture. Transperineal percutaneous laser ablation (TPLA) is a method that places the optical fibre directly into the prostate with the guidance of ultrasound imaging, and the percutaneous transperineal approach is performed distal to the urethra and rectum to protect these structures and reduce urethral or postoperative infection. Several studies on TPLA for BPH treatment have been reported recently; however, high-quality randomised controlled trial (RCT) to evaluate its efficacy, safety, and long-term follow up remain absent.Methods: This study is a multicentre, open-label RCT to assess the efficacy and safety of TPLA vs. TURP to treat BPH. We hypothesise that the TPLA has non-inferior efficacy to TURP in the International Prostate Symptom Score (IPSS) at 3 months changing from the baseline and lower incidence of post-surgery complications. One hundred and fourteen patients with BPH will be recruited at 19 sites and randomly assigned at 1:1 to TPLA or TURP groups. The patients will be followed up at 1, 3, 6, 12, and 24 months after the procedure.Discussion: The study will be the first multicentre clinical trial including 16 participating centres in China, Italy, Switzerland, and Poland with relatively large sample size 114. By comprehensively compare the safety and efficacy of TPLA with TURP in patients with BPH, especially concerning the improvement of lower urinary tract symptoms (LUTS) and complication incidence, the study will help to illustrate the clinical value of TPLA and provide a beneficial alternative treatment for BPH patients.Clinical Trial Registration: The study has been registered on Chinese Clinical Trial Registry (http://www.chictr.org.cn), identifier [ChiCTR1900022739].
Definición y manejo inicial del Trauma craneoencefálico leve
Authors: Watson Hernandez Rebeca Alina , Soto Rodríguez Rebeca 
Published: October 2021

El trauma craneoencefálico es una de las consultas más frecuentes del Servicio de Emergencias, este se divide en leve, moderado y severo según la escala de Glasgow, siin embargo, predomina el trauma leve. Los principales síntomas suelen ser pérdida de consciencia, bradipsiquia y amnesia. Estos pueden persistir por un par de días en lo que se conoce como Síndrome Posconmocional. No todo paciente con TCE leve amerita estudios de imagen, ya que esto sería una exposición innecesaria a la radiación y se daría un uso inadecuado a esta herramienta tan importante.
Application of the Natural Cellulosic Supports for the Treatment of the Industrial Effluents
Authors: BONDAREV Andreea 
Published: October 2021

Wastewater treatment is one of the most important concerns of the research studies in the field of environmental protection. The current study relates to the removal of Crystal violet dye from aqueous solutions through adsorption experiments onto natural cellulosic supports.
Various waste materials that have in their composition lignocellulose are adsorbent supports with low costs for the removal of heavy metal ions and dyes from aqueous solutions.
The use of chemically modified sawdust to obtain an inexpensive adsorbent for removing the Crystal violet dye (CV) from synthetic aqueous solutions has been presented in this research paper. The influence of some important parameters such as: initial dye concentration, adsorbent dose, contact time and temperature on adsorption efficiency for this dye removal have been studied. The Freundlich, Langmuir and Temkin mathematical models have been used to evaluate the data of Crystal violet adsorption from aqueous media using wood sawdust.
The research study shows that beech wood sawdust (Fagus sylvatica), as an agricultural waste which is readily available and relatively inexpensive has the potential to be an applicable alternative adsorbent for Crystal violet dye removal from industrial effluents.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI PERILAKU KONSUMEN DALAM PENGAMBILAN KEPUTUSAN PEMBELIAN PRODUK ROTI ISI KRIM DURIAN (JORDAN BAKERY) DI DESA RANTAU SIALANG KECAMATAN SUNGAI KERUH
Authors: Mindari Ellisyah 
Published: October 2021

Penelitian ini bertujuan untuk untuk menganalisa faktor-faktor yang mempengaruhi perilaku konsumen dalam pengambilan keputusan pembelian. Penelitian ini menggunakan pendekatan kuantitatif. Dalam penarikan sampel yang peneliti lakukan dengan menggunakan rumus slovin. Sampel dalam penelitian ini adalah warga Desa Rantau Sialang dengan jumlah responden sebanyak 97 orang. Metode analisis dengan menggunakan alat analisis dengan bantuan program IBM SPSS Statistics 24. Hasil penelitian ini menunjukan bahwa ada pengaruh yang positif dan signifikan faktor budaya, faktor sosial, faktor pribadi dan faktor psikologis secara bersama-sama terhadap keputusan pembelian dengan nilai Fhitung (146,337) Ftabel (2,471) dan nilai signifikan 0,000. Selanjutnya berdasarkan hasil uji t untuk variabel faktor budaya (X1) diperoleh nilai thitung (-0,119) nilai ttabel (-1,985), nilai signifikan t sebesar 0,905 nilai α (0,05), sehingga dapat disimpulkan bahwa faktor budaya (X1) secara parsial tidak berpengaruh secara signifikan terhadap keputusan pembelian (Y). Sementara itu, variabel faktor sosial (X2) diperoleh nilai thitung (4,771) nilai ttabel (1,985) dan nilai signifikan t sebesar 0,000 nilai α (0,05); variabel faktor pribadi (X3) diperoleh nilai thitung (10,631) nilai ttabel (1,985) dan nilai signifikan t sebesar 0,000 nilai α (0,05); variabel faktor psikologis (X4) diperoleh nilai thitung (-2,713) nilai ttabel (-1,985) dan nilai signifikan t sebesar 0,008 nilai α (0,05). Dengan hasil tersebut berarti bahwa faktor sosial (X2), faktor pribadi (X3) dan faktor psikologis (X4) secara parsial berpengaruh secara signifikan terhadap keputusan pembelian (Y). Kata kunci: Budaya, Sosial, Pribadi, Psikologis dan Keputusan Pembelian.