bluuebunny/crossref_metadata_2025_split huggingface dataset:
French fashion and textile during COVID-19. Once again, flying to high quality and innovation to survive
Authors: Blancheton Bertrand 
Published: December 2021

AbstractThis article studies the consequences of the COVID-19 global health crisis on the fashion and textile industry in France. This crisis is only part of an already long, slow decline in the industry. The paper analyzes the composition and organization of textile industry. It offers data related to: sales, consumption, employees, company size, as well as imports and exports - all highlighting the importance of fashion and textiles in France today. The paper shows how lockdown has asphyxiated production and retail sales. COVID-19 caused the appearance of new challenges: mask production, new aspects of CSR in luxury textiles and the development of antiviral fabrics. Mask production can be considered as a case study useful in the analysis of textile challenges. In this context, the French textile industry should continue to improve on innovation and quality. Promoting labelling on the global market can help the sector to develop its high-end. France is credible to expanding its fashion and textile supply in luxury.
The link between atopic dermatitis and asthma- immunological imbalance and beyond
Authors: Yaneva Martina , Darlenski Razvigor 
Published: December 2021

AbstractAtopic diseases are multifactorial chronic disturbances which may evolve one into another and have overlapping pathogenetic mechanisms. Atopic dermatitis is in most cases the first step towards the development of the atopic march and represents a major socio-economic burden in the industrialized countries. The treatment of atopic diseases is often long-lasting and in some cases with lower effectiveness than expected.In order to prevent the development of the atopic march, the links between the atopic diseases have to be understood. The aim of this review is to present some major points outlining the link between atopic dermatitis and asthma, through a research in the medical literature from recent years.Stratifying patient populations according to the clinical phenotype of their disease and according to specific measurable values (biomarkers) can help to establish the main etiopathogenetic mechanisms of the disease in these populations. This will add predictive value for the evolution of the disease, and will allow the use and research of more targeted therapy in order to stop this evolution and comorbidities.
Squamous cell carcinoma of the uterine cervix metastasising to the thyroid gland: a case report
Authors: Ravindrakumar Sanjeevan , Thalahitiyage Nanduni , Harivallavan Nagenthiram , Jayarajah Umesh , Rodrigo Vitharanage Srimantha Dewsiri 
Published: December 2021

AbstractBackgroundCarcinoma of the uterine cervix (cervical cancer) metastasising to the thyroid gland is a rare phenomenon and only a few cases have been reported. We discuss a patient with cervical cancer presenting with thyroid and cervical lymph node metastasis, exploring the diagnostic difficulty, evaluation and treatment options.Case presentationA previously well 56-year-old female presented with multiple neck lumps for 4 months duration. Examination of the neck revealed multiple firm/hard left cervical lymph nodes with a hard thyroid nodule. There were no abdominal masses however, vaginal examination revealed a hard, unhealthy cervix. Contrast enhanced computed tomography revealed a growth in the uterine cervix with lymph node enlargement in the abdomen, chest and neck along with multiple thyroid nodules. Biopsy of the cervix and cervical lymph node and fine needle aspiration cytology of the thyroid nodules were performed, all revealing a squamous cell carcinoma. Pan-endoscopy performed to rule out any concurrent cancer of the upper aerodigestive tract was negative. The patient was started on palliative therapy, but succumbed to the disease after 6 months.Discussion and conclusionPatients who present with a thyroid nodule along with multiple cervical lymph nodes should be thoroughly assessed for possible metastatic cancers. Metastasis to the thyroid gland indicates a poor prognosis in the background of carcinoma or the uterine cervix. More awareness among the public and primary care providers is necessary regarding freely available screening programmes for early detection of cervical cancer.
Supraceliac aortic cross-clamping to control bleeding from the celiac axis during pancreatic surgery: a case report
Authors: Takano Yuki , Fujioka Shuichi , Shozaki Hironori , Toya Naoki , Ikegami Toru 
Published: December 2021

Abstract
Background
Intraoperative bleeding from the celiac axis (CA) can occur during pancreatic surgery, and appropriate management is essential to avoid critical complications. Here, we have reported a case that was managed with supraceliac aortic cross-clamping (SAC) for arterial bleeding from the CA during pancreatic surgery.

Case presentation
A 70-year-old man was diagnosed with pancreatic cancer located in the pancreatic head and body. Preoperative computed tomography showed a stricture at the root of the CA, which may have been caused by a median arcuate ligament. Pancreaticoduodenectomy with division of the median arcuate ligament was scheduled. Uncontrollable bleeding from the root of the CA was observed during surgery. The bleeding was controlled by performing SAC, and a defect in the CA was confirmed. Arterial wall repair was successfully performed under temporal blood control using SAC. The aortic clamp time was 2 min and 51 s, and the intraoperative blood loss was 480 ml.

Conclusions
Although SAC is primarily a procedure for ruptured abdominal aortic aneurysm, it can be useful for the management of CA injuries during pancreatic surgery.
Molecular characterization of enterotoxigenic Escherichia coli toxins and colonization factors in children under five years with acute diarrhea attending Kisii Teaching and Referral Hospital, Kenya
Authors: Kipkirui Erick , Koech Margaret , Ombogo Abigael , Kirera Ronald , Ndonye Janet , Kipkemoi Nancy , Kirui Mary , Philip Cliff , Roth Amanda , Flynn Alexander , Odundo Elizabeth , Kombich Janeth , Daud Ibrahim 
Published: December 2021

Abstract
Background
Enterotoxigenic Escherichia coli (ETEC) is one of the leading causes of infectious diarrhea in children. There are no licensed vaccines against ETEC. This study aimed at characterizing Escherichia coli for ETEC enterotoxins and colonization factors from children < 5 years with acute diarrhea and had not taken antibiotics prior to seeking medical attention at the hospital.

Methods
A total of 225 randomly selected archived E. coli strains originally isolated from 225 children with acute diarrhea were cultured. DNA was extracted and screened by multiplex polymerase chain reaction (PCR) for three ETEC toxins. All positives were then screened for 11 colonization factors by PCR.

Results
Out of 225 E. coli strains tested, 23 (10.2%) were ETEC. Heat-stable toxin (ST) gene was detected in 16 (69.6%). ETEC isolates with heat-stable toxin of human origin (STh) and heat-stable toxin of porcine origin (STp) distributed as 11 (68.8%) and 5 (31.2%) respectively. Heat-labile toxin gene (LT) was detected in 5 (21.7%) of the ETEC isolates. Both ST and LT toxin genes were detected in 2 (8.7%) of the ETEC isolates. CF genes were detected in 14 (60.9%) ETEC strains with a majority having CS6 6 (42.9%) gene followed by a combination of CFA/I + CS21 gene detected in 3 (21.4%). CS14, CS3, CS7 and a combination of CS5 + CS6, CS2 + CS3 genes were detected equally in 1 (7.1%) ETEC isolate each. CFA/I, CS4, CS5, CS2, CS17/19, CS1/PCFO71 and CS21 genes tested were not detected. We did not detect CF genes in 9 (39.1%) ETEC isolates. More CFs were associated with ETEC strains with ST genes.

Conclusion
ETEC strains with ST genes were the most common and had the most associated CFs. A majority of ETEC strains had CS6 gene. In 9 (39.1%) of the evaluated ETEC isolates, we did not detect an identifiable CF.
Nonlinear analysis of heart rhythm in preeclampsia: a route for translational clinical applications in neuroinflammation
Authors: Reyes-Lagos José Javier , Abarca-Castro Eric Alonso 
Published: December 2021

AbstractPreeclampsia is a pregnancy-specific condition which gets detected through hypertension and excessive protein excretion in urine. While preeclampsia used to be regarded as a self-limiting maternal condition which resolved with the delivery of the placenta, it is nowadays considered a complex and multifactorial disease that affects the offspring. Unfortunately, the etiology and pathophysiology of this multifaceted disorder remain elusive. Recent findings have confirmed that an altered maternal autonomic function may play a vital role in developing preeclampsia in conjunction with an imbalanced maternal immune system. Additionally, further evidence supports the crucial role of an exacerbated immune response driven by a non-infectious trigger during preeclampsia. Therefore, as a sterile inflammation, the elucidation of the neuroinflammatory mechanisms of preeclampsia warrants obtaining relevant knowledge suitable for translational clinical applications.Heart rate variability (HRV) is an affordable and non-invasive method for indirectly assessing the autonomic nervous system and the cholinergic anti-inflammatory pathway (CAP). Notably, the nonlinear analysis of HRV offers novel indexes to explore the neuroimmune interactions in diverse preclinical and clinical settings of inflammation. Given that the dynamics of HRV is nonlinear in health, we hypothesized that a neuroinflammatory condition in preeclampsia might be associated with changes in nonlinear features of maternal and fetal HRV. Thus, the present review aims to present evidence of the potential changes in maternal-fetal HRV associated with neuroinflammatory modifications in preeclamptic women. We considered that there is still a need for assessing the nonlinear features of maternal and fetal HRV as complementary biomarkers of inflammation in this population in future studies, being a potential route for translational clinical applications.
Effect of dietary selenium intake on gut microbiota in older population in Enshi region
Authors: Zhang Zi-xiong , Xiang Hua , Sun Guo-gen , Yang Yan-hua , Chen Chen , Li Tuo 
Published: December 2021

Abstract
Background
The microbial ecosystem in the human gut varies between individuals with differences in diet. Selenium is one of most common trace elements in everyday diet, and selenium intake affects the human gut microbiota. We studied the effect of selenium intake on the gut microbiota in regions of Enshi with different distributions of selenium.

Methods
One hundred elderly subjects (>65 years) were recruited from high-selenium and low-selenium areas in Enshi and blood, nail, and fecal specimens were obtained. The selenium contents in these samples were determined in triplicate by hydride generation atomic fluorescence spectrometry. DNA was extracted from fecal specimens and the microbial diversity was analyzed by 16 S RNA.

Results
The selenium contents in the blood and nails were significantly different between the high- and low-selenium areas, and the composition of the intestinal microbiota, including abundance and extent of intestinal flora, was altered. The function and metabolic pathways of the gut microbiota showed clear differences.

Conclusions
As a trace element in human diet, selenium intake is an important factor that affects the intestinal microbiota and is likely involved in many human diseases. This study provides new clues and ideas for studying the correlation between selenium and human health.
Educational chatbots for project-based learning: investigating learning outcomes for a team-based design course
Authors: Kumar Jeya Amantha 
Published: December 2021

AbstractEducational chatbots (ECs) are chatbots designed for pedagogical purposes and are viewed as an Internet of Things (IoT) interface that could revolutionize teaching and learning. These chatbots are strategized to provide personalized learning through the concept of a virtual assistant that replicates humanized conversation. Nevertheless, in the education paradigm, ECs are still novel with challenges in facilitating, deploying, designing, and integrating it as an effective pedagogical tool across multiple fields, and one such area is project-based learning. Therefore, the present study investigates how integrating ECs to facilitate team-based projects for a design course could influence learning outcomes. Based on a mixed-method quasi-experimental approach, ECs were found to improve learning performance and teamwork with a practical impact. Moreover, it was found that ECs facilitated collaboration among team members that indirectly influenced their ability to perform as a team. Nevertheless, affective-motivational learning outcomes such as perception of learning, need for cognition, motivation, and creative self-efficacy were not influenced by ECs. Henceforth, this study aims to add to the current body of knowledge on the design and development of EC by introducing a new collective design strategy and its pedagogical and practical implications.
Estimating SHmax azimuth with P sources and vertical geophones: Use P-P reflection amplitudes or use SV-P reflection times?
Authors: Hardage Bob , Graul Mike , Hall Tim , Hall Chris , Kelley Mark , Smith Valerie , Modroo Allen 
Published: December 2021

We compared two methods for extracting the azimuth of maximum horizontal stress (SHmax) from 3D land-based seismic data generated by a P source and recorded with vertical geophones. In the first method, we used the direct-SV mode that is produced by all land-based P sources. P sources generate SV illumination that radiates in all azimuth directions from a source station and creates SV-P reflections that are recorded by vertical geophones. Unless stratigraphy has steep dip, SV-P raypaths recorded by vertical geophones are the reverse of P-SV raypaths recorded by horizontal geophones. Thus, SV-P data provide the same S-wave sensitivity to stress fields as popular P-SV data do. In the second method, we retrieved P-P reflections and then performed an amplitude-variation-with-azimuth (AVA) analysis of the amplitude-gradient behavior of P-P reflection wavelets. We did this analysis in narrow azimuth corridors to determine the gradient of reflection-wavelet amplitudes as a function of azimuth. This P-P AVA amplitude-gradient method has been of great interest in the reflection seismology community since it was introduced in the late 1990s. Each of these methods, AVA analysis of the gradient of P-P reflection amplitudes and azimuth-dependent arrival times of SV-P reflections, can be used to determine the azimuth of SHmax stress. We compare the results of the two methods with ground truth measurements of SHmax azimuth at a CO2 sequestration site in the Michigan Basin. SHmax azimuths were determined from P-P and SV-P data at three major boundaries at depths of approximately 3500 ft (1067 m), 5500 ft (1676 m), and 7500 ft (2286 m). Two estimates of SHmax azimuth (one using SV-P data and one using P-P data) were made at each stacking bin inside a 24 mi2 (62 km2) image space. The result was approximately 98,000 estimates of SHmax azimuth across each of these three boundaries for each of these two prediction strategies. Histogram displays of PP AVA gradient estimates had peaks at correct azimuths of SHmax at all three depths, but the spread of the distributions widened with depth and split into two peaks at the deepest boundary. In contrast, each histogram of SHmax azimuth predicted by azimuth-dependent SV-P traveltimes had a single, definitive peak that was positioned at the correct SHmax azimuth at all three boundary depths.
A randomized controlled trial of supplemental oxygen versus air in cancer patients with dyspnea
Authors: Bruera Eduardo , Sweeney Catherine , Willey Jie , Palmer J Lynn , Strasser Florian , Morice Rodolfo C , Pisters Katherine 
Published: December 2021

Context: The symptomatic benefits of oxygen in patients with cancer who have nonhypoxic dyspnea are not well defined. Objective: To determine whether or not oxygen is more effective than air in decreasing dyspnea and fatigue and increasing distance walked during a 6-minute walk test. Patients and methods: Patients with advanced cancer who had no severe hypoxemia (i.e., had an O2 saturation level of] / 90%) at rest and had a dyspnea intensity of] / 3 on a scale of 0–10 (03/4/no shortness of breath, 103/4/worst imaginable shortness of breath) were recruited from an outpatient thoracic clinic at a comprehensive cancer center. This was a double-blind, randomized crossover trial. Supplemental oxygen or air (5 L/min) was administered via nasal cannula during a 6-minute walk test. The outcome measures were dyspnea at 3 and 6 minutes, fatigue at 6 minutes, and distance walked. We also measured oxygen saturation levels at baseline, before second treatment phase, and at the end of study. Results: In 33 evaluable patients (31 with lung cancer), no significant differences between treatment groups were observed in dyspnea, fatigue, or distance walked (dyspnea at 3 minutes: P = 0.61; dyspnea, fatigue, and distance walked at 6 minutes: P = 0.81, 0.37, and 0.23, respectively). Conclusions: Currently, the routine use of supplemental oxygen for dyspnea during exercise in this patient population cannot be recommended.
Cancer pain management in Lanarkshire: a communitybased audit
Authors: Oxenham David , Duncan Robert , Fischbacher Moira 
Published: December 2021

Background: A prospective, longitudinal audit of pain management in patients with cancer was conducted in an unselected community population in Lanarkshire, Scotland. Methods:Using a modified Delphi technique, a recording form was developed and a dedicated project manager was appointed to oversee the development and implementation of the audit. Community staff recorded pain level and analgesic prescribing on consecutive home visits to patients with cancer-related pain. Areas of good and poor prescribing were assessed using standards previously developed for the Scottish Cancer Pain Audit. These results were fed back to prescribers in a variety of ways and used as a focus for a programme of primary care-based education. Results: Five hundred and forty-one patients have been entered in the audit between May 1999 and end October 2002. A total of 3259 visits have been recorded and 88% of general practices in Lanarkshire submitted forms during this period. Pain scores were recorded in 90% of visits. Specific gaps in prescribing practice were identified. Conclusion: The audit demonstrated that it is possible to engage primary care teams in a continuing audit of cancer pain management, which is achievable within the context of normal care. It provided a means to collect and analyse serial data on pain level and pain management and to identify areas of prescribing in need of improvement. Concerted efforts to establish the legitimacy and relevance of the project in the eyes of key stakeholders proved fundamental to encouraging longer-term behavioural change in the management of cancer pain.
Measurable Residual Disease Response and Prognosis in Treatment-Naïve Acute Myeloid Leukemia With Venetoclax and Azacitidine
Authors: Pratz Keith W. , Jonas Brian A. , Pullarkat Vinod , Recher Christian , Schuh Andre C. , Thirman Michael J. , Garcia Jacqueline S. , DiNardo Courtney D. , Vorobyev Vladimir , Fracchiolla Nicola S. , Yeh Su-Peng , Jang Jun Ho , Ozcan Muhit , Yamamoto Kazuhito , Illes Arpad , Zhou Ying , Dail Monique , Chyla Brenda , Potluri Jalaja , Döhner Hartmut 
Published: December 2021

PURPOSE There is limited evidence on the clinical utility of monitoring measurable residual disease (MRD) in patients with acute myeloid leukemia treated with lower-intensity therapy. Herein, we explored the outcomes of patients treated with venetoclax and azacitidine who achieved composite complete remission (CRc; complete remission + complete remission with incomplete hematologic recovery) and MRD < 10–3 in the VIALE-A trial. METHODS The patients included in this report were treated with venetoclax and azacitidine. Bone marrow aspirate samples for multiparametric flow cytometry assessments were collected for central analysis at baseline, end of cycle 1, and every three cycles thereafter. MRD-negative response was defined as < 1 residual blast per 1,000 leukocytes (< 10–3 or 0.1%) with an estimated analytic sensitivity of 0.0037%-0.0027%. CRc, duration of remission (DoR), event-free survival (EFS), and overall survival (OS) were assessed. A multivariate Cox regression analysis identified prognostic factors associated with OS. RESULTS One hundred sixty-four of one hundred ninety (86%) patients with CRc were evaluable for MRD. MRD < 10–3 was achieved by 67 of 164 (41%), and 97 of 164 (59%) had MRD ≥ 10–3. The median DoR, EFS, and OS were not reached in patients with CRc and MRD < 10–3, and the 12-month estimates for DoR, EFS, and OS in this group were 81.2%, 83.2%, and 94.0%. Among patients with CRc and MRD ≥ 10–3, the median DoR, EFS, and OS were 9.7, 10.6, and 18.7 months. Multivariate analysis showed that CRc with MRD < 10–3 was a strong predictor of OS (adjusted hazard ratio = 0.285; 95% CI, 0.159 to 0.510; P < .001). CONCLUSION Patients who achieved CRc and MRD < 10–3 with venetoclax and azacitidine had longer DoR, EFS, and OS, than responding patients with MRD ≥ 10–3.
Upgrading the Chemotherapy Consent: Trading in Paper for Tablet
Authors: Wu Lesley , Smith Cardinale B. , Parra Jessica , Liu Mark , Theroux Haley Hines , Bhardwaj Aarti S. 
Published: December 2021

PURPOSE: Our institution participated in the Oncology Care Model, which required us to include many of the 13 elements of the National Academy of Medicine (NAM) care plan into care pathways for our patients. We optimized our existing chemotherapy consent process to meet this need and maximized completion. METHODS: Our multidisciplinary committee developed a three-phase Plan-Do-Study-Act process in our breast cancer clinic: (1) update and educate providers on our paper chemotherapy form with multiple components of the NAM care plan including prognosis and treatment effects on quality of life; (2) piloted an electronic chemotherapy consent form to decrease the administrative burden; and (3) autopopulated fields within the electronic consent. We assessed feedback after cycle 1 and created a Pareto chart. The outcome measure was percent completion of chemotherapy consent documents. RESULTS: Baseline monthly random chart audit of 40 patients revealed 20% of paper chemotherapy consent forms were completed in their entirety among patients. When we re-educated clinicians about the new paper consent containing the NAM elements, compliance rose to nearly 30%. A Pareto chart confirmed that content redundancy and wordiness were leading to under-completion. After creating and piloting the electronic consent, compliance increased to 90%. Finally, autopopulation with drop-down selections increased and sustained completion to 100%. CONCLUSION: Incorporating regulatory requirements into an existing workflow using Plan-Do-Study-Act methodology can reduce administrative burden on clinicians. Additional use of innovative technology can further increase clinician compliance with regulatory requirements while delivering high-value quality care to patients with cancer.