bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preventing Type 2 Diabetes in Women with Previous Gestational Diabetes: Reviewing the Implementation Gaps for Health Behavior Change Programs
Authors: Lim Siew , Chen Mingling , Makama Maureen , O'Reilly Sharleen 
Published: January 2021

AbstractGestational diabetes mellitus (GDM) places a woman at high risk of developing subsequent type 2 diabetes mellitus (T2DM), particularly in the first 5 years postpartum. Engaging women in health behavior change during this period is challenging and current diabetes prevention programs were developed for middle-aged adults, all of which have limited the evidence on successful implementation for this high-risk population. In this review, we will first summarize the effects of existing diabetes prevention programs in women with a history of GDM. Second, we suggest that the programs need to be modified according to the facilitators and barriers faced by this population. Third, we propose that improving program penetration, fidelity, and participation is critical for population-level success. Finally, we outline the research priorities to improve the implementation of diabetes prevention programs for postpartum women with a history of GDM.
Premature and Early Menopause in Relation to Cardiovascular Disease
Authors: Schipper Izaäk , Louwers Yvonne V. 
Published: January 2021

AbstractPostmenopausal women have an increased risk for cardiovascular diseases. It has been postulated that the loss of ovarian function and subsequent deficiency of endogenous estrogens after menopause contributes to this elevated risk of cardiovascular disease in postmenopausal women. Compared with woman entering menopause at the mean age of 51 years, in women with early menopause or premature ovarian insufficiency the risk for cardiovascular disease is even greater. These women lack the cardioprotective effect of endogenous estrogens for many more years than do women entering natural menopause. The majority of data assessing the risk of cardiovascular disease in relation to age at menopause and specifically premature menopause are derived from large epidemiological cohort studies. In addition, observations in women undergoing bilateral oophorectomy at an early age provide convincing evidence regarding association between early menopause or POI and the development of cardiovascular events and mortality. Moreover, genetic variants associated with earlier age at menopause have also been found to increase the risk of cardiovascular events in women. It has been substantiated that hormone replacement therapy (HRT) decreases the risk for ischemic heart disease and eliminates the increased cardiovascular disease mortality. It is therefore crucial to start HRT as soon as possible, particularly in women with premature ovarian insufficiency.
Comparison of Cases with Anterior Cruciate Ligament Reconstruction Accompanied by Simultaneous Medial Meniscus Bucket Handle Tear Repair and Isolated Medial Meniscus Bucket Handle Tear Repair
Authors: Akalın Yavuz , Avcı Özgür , İnce Savaş İ. , Çevik Nazan , Şahin İsmail G. , Öztürk Alpaslan 
Published: January 2021

AbstractThe aim of this study was to evaluate the success of the all-inside repair technique for medial bucket-handle meniscus tear (BHMT) and the factors affecting healing. A total of 36 patients with BHMT who were operated between 2012 and 2018 and completed final follow-up examinations were included in the study. Functional evaluation was made with the International Knee Documentation Committee (IKDC) score, Lysholm score, and Tegner score. Healing was evaluated on magnetic resonance imaging (MRI) slices. The patients were evaluated with respect to the effect on healing of factors such as demographic data, body mass index (BMI), smoking status, anterior cruciate ligament tear reconstruction (ACLTR) applied at the same time as BHMT repair, and the tear being chronic or acute. The mean age of the patients was 28.6 ± 8.6 years (range,18–46 years), the mean follow-up period was 25.8 ± 13.9 months (range, 13–59 months), and BMI was mean 25.6 ± 3.5 kg/m2 (range, 20.1–30.5 kg/m2). The meniscus tears were acute in 16 (44.4%) patients and chronic in 20 (55.6%). ACLTR was applied together with BHMT repair in 25 patients. The hybrid technique, as the outside-in technique in addition to the all-inside technique, was applied to 12 (33.3%) patients, where there was seen to be extension to the anterior horn. The failure rate was determined as 27.8% according to the postoperative MRI evaluation and the Barrett criteria. No positive or negative statistically significant effect on healing was determined of chronic BHMT or of simultaneous application of ACLTR (p = 1.00 and 0.457, respectively). Cigarette smoking and high BMI were determined to have a statistically significant negative effect on healing (p = 0.026 and 0.007, respectively). In conclusion, it can be seen that the success of the all-inside technique for BHMT remains controversial. Due to the features of the application, it can be used in meniscus tears of the posterior horn only. In the current study, with the success rate of 72.2% of the all-inside technique in meniscus body tears, it was seen that a high success rate could not be achieved.
The Adjustment of the Rotational Alignment of the Distal End of the Extramedullary Guide to the Anteroposterior Axis of the Proximal Tibia in Total Knee Arthroplasty
Authors: Mizu-uchi Hideki , Kido Hidehiko , Chikama Tomonao , Kamo Kenta , Kido Satoshi , Nakashima Yasuharu 
Published: January 2021

AbstractThe optimal placement within 3 degrees in coronal alignment was reportedly achieved in only 60 to 80% of patients when using an extramedullary alignment guide for the tibial side in total knee arthroplasty (TKA). This probably occurs because the extramedullary alignment guide is easily affected by the position of the ankle joint which is difficult to define by tibial torsion. Rotational direction of distal end of the extramedullary guide should be aligned to the anteroposterior (AP) axis of the proximal tibia to acquire optimal coronal alignment in the computer simulation studies; however, its efficacy has not been proven in a clinical setting. The distal end of the guide can be overly displaced from the ideal position when using a conventional guide system despite the alignment of the AP axis to the proximal tibia. This study investigated the effect of displacement of the distal end of extramedullary guide relative to the tibial coronal alignment while adjusting the rotational alignment of the distal end to the AP axis of the proximal tibia in TKA. A total of 50 TKAs performed in 50 varus osteoarthritic knees using an image-free navigation system were included in this study. The rotational alignment of the proximal side of the guide was adjusted to the AP axis of the proximal tibia. The position of the distal end of the guide was aligned to the center of the ankle joint as viewed from the proximal AP axis (ideal position) and as determined by the navigation system. The tibial intraoperative coronal alignments were recorded as the distal end was moved from the ideal position at 3-mm intervals. The intraoperative alignments were 0.5, 0.9, and 1.4 degrees in valgus alignment with 3-, 6-, and 9-mm medial displacements, respectively. The intraoperative alignments were 0.7, 1.2, and 1.7 degrees in varus alignment with 3-, 6-, and 9-mm lateral displacements, respectively. In conclusion, the acceptable tibial coronal alignment (within 2 degrees from the optimal alignment) can be achieved, although some displacement of the distal end from the ideal position can occur after the rotational alignment of the distal end of the guide is adjusted to the AP axis of the proximal tibia.
Specific Cognitive Changes due to Hippocalcin Alterations? A Novel Familial Homozygous Hippocalcin Variant Associated with Inherited Dystonia and Altered Cognition
Authors: Siegert Sandy , Schmidt Wolfgang M. , Pletschko Thomas , Bittner Reginald E. , Gobara Sonja , Freilinger Michael 
Published: January 2021

Abstract
Background Recent research suggested an hippocalcin (HPCA)-related form of DYT2-like autosomal recessive dystonia. Two reports highlight a broad spectrum of the clinical phenotype. Here, we describe a novel HPCA gene variant in a pediatric patient and two affected relatives.
Methods Whole exome sequencing was applied after a thorough clinical and neurological examination of the index patient and her family members. Results of neuropsychological testing were analyzed.
Results Whole exome sequencing revealed a novel homozygous missense variant in the HPCA gene [c.182C>T p.(Ala61Val)] in our pediatric patient and the two affected family members. Clinically, the cases presented with dystonia, dysarthria, and jerky movements. We observed a particular cognitive profile with executive dysfunctions in our patient, which corresponds to the cognitive deficits that have been observed in the patients previously described.
Conclusion We present a novel genetic variant of the HPCA gene associated with autosomal recessive dystonia in a child with childhood-onset dystonia supporting its clinical features. Furthermore, we propose specific HPCA-related cognitive changes in homozygous carriers, underlining the importance of undertaking a systematic assessment of cognition in HPCA-related dystonia.
Initial Experience with the NAVIO Robotic-Assisted Total Knee Replacement—Coronal Alignment Accuracy and the Learning Curve
Authors: Collins Kade , Agius Paul A. , Fraval Andrew , Petterwood Josh 
Published: January 2021

AbstractOne of the primary aim of total knee arthroplasty (TKA) is restoration of the mechanical axis of the lower limb. Maintenance of the mechanical axis within 3 degrees of neutral has been shown to result in improved clinical results and implant longevity. The aim of this study was to investigate the efficacy of this robotic-assisted system in coronal plane component positioning in TKA. We also describe the learning curve associated with adoption of this technology. A total of 72 total knee replacements were completed between November 2017 and September 2018 by a single surgeon using the robotic-assisted surgery (RAS) system. Cases were recorded from the time the study surgeon first adopted this technology and represent the “learning curve.” Pre- and postoperative coronal weight-bearing alignments were measured and intraoperative robotic-assisted registration data and duration of use were collected. Of the 72 TKAs in this series, 93.3% were corrected to the desired alignment of within 3 degrees of neutral. The knees that were not corrected to neutral had a mean preoperative alignment of 11.57 degrees of deformity as compared with 4.29 degrees for those that were corrected to neutral. A learning curve effect during adoption of this new technology was not found when analyzing RAS usage time. The RAS system produced accurate coronal alignment in TKA in more than 93% of cases with no learning curve effect. Our study suggests that this system is easily adopted, safe, and accurate.
Mobile Stroke Units: Current and Future Impact on Stroke Care
Authors: Bowry Ritvij , Grotta James C. 
Published: January 2021

AbstractIschemic stroke is a leading cause of death and major disability that impacts societies across the world. Earlier thrombolysis of blocked arteries with intravenous tissue plasminogen activator (tPA) and/or endovascular clot extraction is associated with better clinical outcomes. Mobile stroke units (MSU) can deliver faster tPA treatment and rapidly transport stroke patients to centers with endovascular capabilities. Initial MSU trials in Germany indicated more rapid tPA treatment times using MSUs compared with standard emergency room treatment, a higher proportion of patients treated within 60 minutes of stroke onset, and a trend toward better 3-month clinical outcomes with MSU care. In the United States, the first multicenter, randomized clinical trial comparing standard versus MSU treatment began in 2014 in Houston, TX, and has demonstrated feasibility and safety of MSU operations, reliability of telemedicine technology to assess patients for tPA eligibility without additional time delays, and faster door-to-groin puncture times of MSU patients needing endovascular thrombectomy in interim analysis. Scheduled for completion in 2021, this trial will determine the cost-effectiveness and benefit of MSU treatment on clinical outcomes compared with standard ambulance and hospital treatment. Beyond ischemic stroke, MSUs have additional clinical and research applications that can profoundly impact other cohorts of patients who require time-sensitive neurological care.
Assessment of Depression, Anxiety, and Sleep Disturbance in COVID-19 Patients at Tertiary Care Center of North India
Authors: Yadav Ramakant , Yadav Prashant , Kumar Sushil Shukla , Kumar Raj 
Published: January 2021

Abstract

Background and Objective The novel Coronavirus pandemic surfaced in Wuhan, China in December 2019 and spread rapidly across the globe. In recent available literature, most of the studies were done to estimate the burden of psychiatric problems among general population due to this pandemic, Therefore, this study was planned to assess depression, anxiety, and sleep disturbance among Coronavirus disease-2019 (COVID-19) patients.

Materials and Methods A hospital-based, cross-sectional study was done from June 2020 to August 2020 among 100 COVID-19 patients who were admitted and fulfilled the inclusion criteria. Assessment of depression, anxiety, and sleep disturbance were done by patient health questionnaire-9 (PHQ-9) scale, generalized anxiety disorder-7 (GAD-7) scale and Pittsburg sleep quality index (PSQI), respectively.

Results In this study, 73% were males and 27% were females. The mean age of the patients in present study was 42.90 ± 16.33 years. This study reveals that depression was in 27%, anxiety in 67%, and sleep disturbance in 62% of patients. Depression and anxiety were found significantly associated with presence of comorbidity and severity of illness (p < 0 0.05). The association of sleep disturbance with severity of illness was also found statistically significant (p < 0.05).

Conclusion The risk of psychological stress is high in COVID-19 patients. The psychological problems among COVID-19 patients are commonly related to the consequences of disease, and severity and contagiousness of the disease. Therefore, in this present pandemic situation, it is more important to identify these psychological problems among COVID-19 patients, so that better care and timely interventions can be done with respect to psychological issues.
Radiofrequency Rejuvenation of the “Tweener” Patient: Under, Over, or Through the Skin
Authors: Kam Joanna , Frost Ariel , Bloom Jason D. 
Published: January 2021

AbstractThe demand for noninvasive facial rejuvenation continues to increase as younger, well-informed patients enter the aesthetic market. We refer to a subset of these patients as “tweeners,” those who present with early signs of neck and facial aging, but who have not yet developed changes significant enough to warrant a traditional excisional surgery approach. Many of these patients are in search of a minimally invasive intervention, a bridge in between observation and surgery. The authors describe their experience with radiofrequency (RF) technology as an in-office tool to address the aging face in a select patient population. This review also attempts to comprehensively search the existing body of literature to describe the RF technologies and devices available for facial rejuvenation. The efficacy and safety profiles of the devices are discussed, and the devices are categorized by their method of RF delivery—over (contact), through (microneedle), and under (percutaneous) the skin.
Permittivity order modulation by intrinsic dielectric coupling
Authors: Yang Qirui , Li Yongqiang , Zhang Jiarui , Qi Qi , Chen Kai , Wang Ying , Liu Junming , Zhu Jinsong 
Published: January 2021

The room-temperature permittivity is reduced by one order of magnitude in a wide frequency range during each step, when the stoichiometric proportion of Cu in CaCu3Ti4O12 is decreased from 3 to 2 and then to 1. The frequency-independent reduction can be applied down to 140 K. Such an almost frequency- and temperature-independent decrease in the permittivity magnitude order suggests the existence of intrinsic dielectric coupling between binary dielectric polarization species, by which the less polaron-like 3d electrons from B-site copper ions more strongly depress the permittivity contribution from one-dimensional, anti-parallel, mutually independent, and finite length dipole chains of thermally activated off-center displacements of A-site titanium ions.
A glycan FRET assay for detection and characterization of catalytic antibodies to theCryptococcus neoformanscapsule
Authors: Crawford Conor J. , Wear Maggie P. , Smith Daniel F. Q. , d’Errico Clotilde , McConnell Scott A. , Casadevall Arturo , Oscarson Stefan 
Published: January 2021

SignificanceCryptococcus neoformansis a global fungal pathogen that is a frequent cause of a life-threatening meningoencephalitis. There is a need for new therapies and vaccines. A better understanding of antibodies associated with its major virulence factor, the capsule, will allow the development of new antibody therapeutics, inform vaccine design, and further basic knowledge of antibody structure-function. Here, we demonstrate several antibodies against the capsule have innate glycosidase activity, and these antibodies can cause hydrolysis of the native capsule. This catalytic activity results in a disruption of cellular integrity and increased ease of phagocytosis by macrophages. To date, identifying this elusive quality in antibodies has been difficult. We have simplified this process by the development of a high-throughput FRET assay. This approach could be generalized to identify other antibodies catalytic against glycans.
The cognitive poetics of English-Chinese advertisement translation
Authors: Cui Ying 
Published: January 2021

AbstractAdvertisements often use poetic methods to increase aesthetic value, evoke emotion, and strengthen recipients’ impression. This study explores the cognitive poetics of English-Chinese advertisement translation and investigates how poetic methods are treated in translation. It draws upon poetics, psychology, and translation to study a corpus of 198 English-Chinese poetic advertisements. Two major poetic methods in the advertising discourse – repetition and image establishment – will be outlined, as well as their functions in invoking an emotional response and lasting impression. Then, analysis of a representative example will demonstrate how the poetic elements are transferred across languages, and the results of two surveys confirm their effects. The discussion is intended to shed light on the audience’s reception and perception of advertisements and provide translators with practical reference regarding poetic methods and the importance of the audience’s emotion and impression.
Influence of aerosol injection on the liquid chemistry induced by an RF argon plasma jet
Authors: Sremački Ivana , Bruno Giuliana , Jablonowski Helena , Leys Christophe , Nikiforov Anton , Wende Kristian 
Published: January 2021

Abstract
A radio-frequency driven plasma jet in annular geometry coupled with an aerosol injection into the effluent is proposed for the controllable reactive oxygen species (ROS)/reactive nitrogen species (RNS) production and delivery on biological targets in the context of plasma medicine, e.g. wound care. The role of the aqueous aerosol in modulating the reactive species production is investigated by combining physical and chemical analytics. Optical emission spectroscopy, electron paramagnetic resonance spectroscopy, and a biochemical model based on cysteine as a tracer molecule have been applied, revealing that aerosol injection shifts the production of ROS from atomic and singlet oxygen toward hydroxyl radicals, which are generated in the droplets. Species generation occurred mainly at the droplets boundary layer during their transport through the effluent, leading to a limited cysteine turnover upon introduction into the aerosol solution. The subsequent delivery of unmodified cysteine molecules at a target suggested the application of the plasma source for the topical delivery of drugs, expanding the potential applicability and effectiveness. The presence of RNS was negligible regardless of aerosol injection and only traces of the downstream products nitrate and nitrate were detected. In summary, the aerosol injection into the effluent opens new avenues to control UV radiation and reactive species output for the biomedical applications of non-thermal plasma sources, reaching out toward the regulation, safety, and efficacy of targeted applications.
The dependence of the emission from MQWs on the indium content in the underlying InGaN templates: experimental and modeling results
Authors: Abdelhamid Mostafa , Routh Evyn L , Bedair S M 
Published: January 2021

Abstract
The effect of underlying highly relaxed In
y
Ga1-y
N templates on In
x
Ga1-x
N multiple quantum wells (MQWs), where x> y, is investigated. Photoluminescence (PL) measurements and tested light emitting diodes (LEDs) show that relaxed In
y
Ga1-y
N templates with y ∼ 10% can cause a red shift in MQWs emission of

Δ

E
∼
0.33

eV

. This red shift is attributed to the reduced strain in the MQWs, resulting in a decrease in the MQWs band gap, along with an increase in indium incorporation in the QWs due to composition pulling effect. Theoretical modeling was applied to study the effect of the template’s indium content and its degree of relaxation on the observed red shift in MQW emission. The proposed model uses the PL emission data from the MQW to predict the indium content in the MQWs grown on GaN and on InGaN templates. Using this model, we are able to predict the dependence of both the amount of the red shift and the indium incorporation enhancement in the QWs on the In-content in the underlying templates. We are not aware of any similar modeling activities that reported such predictions. LED devices were fabricated using the In
y
Ga1-y
N templates and compared to conventional LED structure grown on GaN, showing a red shift in electroluminescence that agrees with the PL results.
Polydopamine–cellulose nanofiber composite for flexible electrode material
Authors: Muthoka Ruth M , Roy Sunanda , Kim Hyun Chan , Yoon Hargsoon , Zhai Lindong , Kim Jaehwan 
Published: January 2021

Abstract
This research is intended to develop a flexible and dopamine-based electrode material by blending polydopamine (PDA) with cellulose nanofiber (CNF). Inspired by its unique adhesion behavior, dopamine, a biomimetic protein, was utilized to form a strong adhesion between the CNFs. Herein, we report PDA concentration’s effect to produce PDA-CNF composite showing good electrochemical redox response, good mechanical properties, and improved thermal stability. The PDA-CNF composite with CNF:PDA = 5:2.5 showed the highest Young’s modulus, the strain at break, and toughness among other CNF:PDA combination composites. A PDA-CNF working electrode was made using a microfabrication process. Cyclic voltammetry analysis showed high ion permeability through the CNF backbone structure and oxidation process by PDA in PDA-CNF electrode. These findings indicate the feasibility of the PDA-CNF composite for enhanced longevity in flexible electrode applications utilizing the combination of high mechanical flexibility and thermal stability.