bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved survival in multiple Myeloma patients undergoing autologous stem cell transplantation is entirely in the standard cytogenetic risk groups
Authors: Afram Gabriel , Susek Katharina Helene , Uttervall Katarina , Wersäll Johanna Dehlsen , Wagner Arnika Kathleen , Luong Vincent , Lund Johan , Gahrton Gösta , Alici Evren , Nahi Hareth 
Published: January 2021

AbstractIntroductionNovel drugs and drug combinations have improved outcomes for multiple myeloma patients. However, subgroups of patients still have a poor progression‐free survival (PFS) and overall survival (OS). In an attempt to identify how the novel drugs affect the outcome in standard‐risk and high‐risk patients, respectively, we have investigated 715 multiple myeloma (MM) patients who have undergone high dose treatment followed by autologous stem cell transplantation at our center during 1995 ‐ 2020. Outcomes during three time periods, 1995‐1999 (period I), 2000‐2009 (period II), and 2010‐2020 (period III), were compared separately for standard‐risk and high‐risk patients. Risk stratification was based on chromosome analysis for periods II and III.ResultsThe whole cohort of patients showed significantly improved OS with time during the three periods being at a median of 5.8, 7.0, and 10.0 years, respectively. There is also a weak tendency for improved PFS, that is, a median of 2.4, 2.6, and 2.9 years, respectively, during the same periods. However, the separate analysis of standard‐risk and high‐risk patients showed that the overall improvement with time was due to improved standard‐risk patients (median OS 8.4 years for the period I and not reached for period II and III). In contrast, no significant improvement was seen in high‐risk patients. For patients with del17p, PFS was even worse during period III as compared to period II (median 1.6 vs 3.2 years respectively).ConclusionOur results show that the dramatic improvement in outcome for MM patients during the last 20 years only applies for standard‐risk patients, while high‐risk MM patients still are doing poorly, indicating that the novel drugs developed during this time are preferentially effective in standard‐risk patients. New treatment modalities like CAR‐T cells, CAR‐NK cells, and/or bispecific antibodies should be tried in clinical studies early in the course of the disease, especially in patients with high‐risk cytogenetics.
Democracy and bureaucracy in newly industrialized countries: A systematic comparison between Latin America and East Asia
Authors: de Avila Gomide Alexandre 
Published: January 2021

AbstractThis article analyzes the political‐institutional determinants of bureaucracy quality among a group of newly industrialized countries in Latin America and East Asia democratized in the Third Wave. Four causal conditions are examined for the occurrence of higher levels of bureaucratic “weberianess” in the selected cases: historical sequence, political parties' institutionalization, electoral competition, and ethnic politics. The study employs the fuzzy‐set qualitative comparative analysis to explore the expectation that each of these conditions' implications depends on other conditions' presence or absence. The findings disconfirm claims about the critical role of party system institutionalization for Weberian bureaucracies in new democracies. Besides, the analysis did not declare a professional public administration's prior existence before democratization as a necessary or sufficient condition for the outcome of interest. Finally, although the electoral competition was declared necessary for the outcome occurrence, it does not imply the same result if combined with ethnic politics.
Littering behaviour: A systematic review
Authors: Chaudhary Abdul Haseeb , Polonsky Michael Jay , McClaren Nicholas 
Published: January 2021

AbstractLittering is a widespread problem that has negative consequences for the wellbeing of society and has been discussed in a wide range of subject areas. However, the lack of a unified understanding of the literature on littering presents an opportunity for a synthesis of the literature. This systematic review integrated the findings from 70 journal articles spanning 48 years. The articles were analysed for use of theories, models, methods, locations of study, variables and study findings. The researchers also undertook a content analysis of the literature to understand the evolution of approaches across time. The findings show that situational and psychological factors have often been studied using the ‘Focus Theory of Normative Conduct’ and the ‘Integrative Behaviour Model’. However, the findings have been inconsistent, with varying results for some of the situational, psychological and administrative factors. The content analysis identified that the literature from 1971 to 2006 was mostly confined to developed countries (80%) with the majority of studies examining situational and psychological factors. The gaps in the literature provided a basis for proposing five future research directions including the development of social marketing interventions by improving the theoretical groundings of previous works. As littering is consumer behaviour, it is also important to investigate the role of businesses as an integral part of the consumer exchange process to assist in improving the situation. The detailed future research directions and the conclusions of the review are presented.
Protecting children: Testing a stop‐and‐take‐a‐break advergame intervention strategy
Authors: Cho Eunji , Riddle Karyn 
Published: January 2021

AbstractResearch suggests information‐based advertising literacy efforts do not consistently reduce the persuasive effects of advergames on young children. Therefore, the present study builds upon prior research, suggesting a distraction might reduce children's engagement with advergames, lowering their effectiveness through more affective routes. In an experiment conducted on 134 children ages 8–11 in South Korea, we randomly assigned participants to play an advergame either with or without a “stop‐and‐take‐a‐break” intervention. Results suggest the stop‐and‐take‐a‐break intervention strategy works by decreasing player presence, which is subsequently correlated with decreases in mood, game liking and positive attitudes towards the advertised brand. Theoretical and practical implications of the findings are discussed.
Analysis of 3702 patients with acne vulgaris and concomitant comorbidities in Turkey: a multi‐centered, prospective, controlled study
Authors: Ünal Emine , Karadağ Ayşe Serap , Şikar Aktürk Aysun , Dizen Namdar Nazlı , Kelekçi Kıymet Handan , Aksoy Berna , Özlü Emin , Baykal Leyla , Karaman Göksun , Sarıcaoğlu Hayriye , Zindancı İlkin , Balta İlknur , Turan Çağrı , Can Kuru Burçe 
Published: January 2021

AbstractBackgroundAcne vulgaris is a chronic inflammatory skin disease that affects the pilosebaceous unit. Although it is considered to be a skin‐limited disease, different clinical studies have recently been published in which the disease is accompanied by systemic symptoms. In this study, systemic comorbidities accompanying acne vulgaris and the relationship between existing comorbidities and disease severity are investigated.MethodsThis prospective multicenter study was conducted by the Turkish Society of Dermatology Acne Study Group. Twelve dermatology clinics and 14 clinicians throughout Turkey participated in the study. A structured physician‐administered questionnaire was used to collect patient demographics, clinical findings, and lifestyle data. Physicians recorded each participant’s medical history, including current and past comorbidities, duration of any comorbidity, smoking, and drinking. Body mass index (BMI) was calculated.ResultsThere were 3022 patients in the adolescent acne group and 897 in the control group. The incidence of nonmigraine headache in adolescents with acne was significantly higher than in the nonacne group (P = 0.019). There were 680 patients in the postadolescent acne group and 545 in the control group. In the postadolescent group, incidence of metabolic disease was lower than the control group (P = 0.003). In the postadolescent group, premenstrual syndrome (P < 0.001) and PCOS (P = 0.007) were more common than the control group.ConclusionsIn this study, we observed that acne vulgaris does not cause systemic comorbidities. There is also a need for new studies involving a large number of patients to illuminate systemic diseases accompanying acne vulgaris.
Chemical, thermal and structural properties of alkaline‐cooked (nixtamalised) chickpea (Cicer arietinum) flours
Authors: Mariscal‐Moreno Rosa María , Figueroa‐Cárdenas Juan de Dios , Santiago‐Ramos David , Aguilar Arteaga Karina , Flores Casamayor Verónica , Rincón‐Aguirre Alexandra 
Published: January 2021

SummaryThe present study examined how the alkaline cooking process affects the chemical, thermal and structural properties of the chickpea, evaluating different lime concentrations. Cooking was carried out at 94 °C, with two times of water for 15 min with five different lime concentrations. Regarding chemical composition, a decrease in protein and fat was observed: from 23.64% to a range of 18.26–19.93% for protein and from 8.20% to a range of 6.05–7.74% for fat. However, an increase was observed for ash and mineral content. The same pattern was observed for potassium. Raw chickpea did not present endotherm retrogradation, but a higher endotherm retrogradation was presented in chickpea cooked without lime, denoting that nixtamalisation decreased retrogradation. Additionally, V‐amylose relative crystallinity increased with concentration of lime. Protein digestibility increases by β‐sheet dismissing structure. Finally, it was observed that steeping time plays a key role in the nixtamalisation process.
What is the most anticipated change induced by treatment using gender‐affirming hormones in individuals with gender incongruence?
Authors: Masumori Naoya , Baba Tsuyoshi , Abe Teruo , Niwa Koji 
Published: January 2021

ObjectivesTo identify the most eagerly anticipated change resulting from hormone therapy using gender‐affirming hormones for patients with gender incongruence undergoing a clinical trial.MethodsPatients diagnosed with gender identity disorders based on the International Classification of Diseases 10th revision classification at three institutions in Japan for whom hormone therapy using gender‐affirming hormones was initiated were analyzed. They were asked what the most anticipated change was due to gender‐affirming hormone that they had thought of between giving informed consent and the first administration of the drug.ResultsThe responders were 336 transgender men who were administered androgens and 48 transgender women who received estrogens. The median age at commencement of hormone therapy was 24 years for transgender men and 28 years for transgender women. For transgender men, the most frequent answer was cessation of menses (52.7%) followed by a deepened voice (32.4%). For transgender women, breast development (35.4%) was the most anticipated change, followed by gynoid fat deposition (29.2%).ConclusionsCessation of menses in transgender men and breast development/gynoid fat deposition in transgender women might represent primary end‐points in clinical trials evaluating the efficacy of hormonal treatment in these patients.
Bisphenol A at a human exposed level can promote epithelial‐mesenchymal transition in papillary thyroid carcinoma harbouring BRAFV600E mutation
Authors: Li Liuli , Li Hao , Zhang Jun , Gao Xin , Jin Hao , Liu Renqi , Zhang Zhen , Zhang Xuan , Wang Xichang , Qu Peng , Zhao Yuejiao , Lu Xiaobo 
Published: January 2021

AbstractBisphenol A (BPA), a ubiquitous endocrine‐disrupting chemical, alters the function of endocrine system and enhances the susceptibility to tumorigenesis in several hormone‐dependent tumours as thyroid carcinoma. About 50% of papillary thyroid cancers (PTC), the most common type of thyroid malignancy, harbours the BRAFV600E mutation. This study aimed to investigate a potential combined effect of BPA exposure and BRAFV600E mutation on epithelial‐mesenchymal transition (EMT) in PTC. Firstly, the level of BPA in plasma, the evaluation of BRAFV600E mutation and the level of EMT‐related proteins in PTC samples were individually determined. Additionally, the migration, invasion, colony formation capacity and the expression of EMT‐related proteins after exposure to BPA were precisely analysed in vitro thyroid cells genetically modified by the introduction of BRAFV600E mutation. Moreover, ERK‐Cox2 signalling pathway was also introduced to explore the possible mechanism in PTC development. As expected, whether the clinical investigation or cultured thyroid cells demonstrated that BPA at a concentration compatible with human exposed levels (10‐7 M) synergized with the BRAFV600E mutation promoted EMT via the activation of ERK‐Cox2 signalling pathway. Our findings offer some evidence that BPA as an environmental risk factor can facilitate the progression of PTC harbouring BRAFV600E mutation.
BIBLIOMETRIC TECHNIQUES AND THEIR USE IN BUSINESS AND ECONOMICS RESEARCH
Authors: Rousseau Sandra , Rousseau Ronald 
Published: January 2021

AbstractBibliometric indicators and bibliometric techniques have been used in the domains of business and economics (BE) in the context of network studies and the evaluation of universities, journals and researchers, among other purposes. Using a strengths, weaknesses, opportunities and threats analysis as a general framework, we present an overview of the strengths, weaknesses, opportunities and threats related to the use of mainstream bibliometrics in BE. Several weaknesses in the use of bibliometric indicators for research evaluation in BE, and, in general, are discussed. Misuse of bibliometric indicators may lead to goal displacement and gender bias. Yet, being aware of possible problems leads to opportunities for further developments and applications of bibliometrics in the field of BE. We propose that traditional research evaluation should evolve into evaluative inquiry, a method where bibliometric indicators play a role, but in which all aspects of life and work of a scientific professional can be taken into account and assessment is relabelled in positive terms such as organizational and individual development, care and support.
A case of ovarian stimulation for fertility preservation in a patient with Philadelphia chromosome‐positive acute lymphoblastic leukemia after treatment with dasatinib
Authors: Ogawa Tatsuyuki , Ogi Maki , Hirata Shuji 
Published: January 2021

AbstractTyrosine kinase inhibitors (TKIs) are effective for treating Philadelphia chromosome‐positive acute lymphoblastic leukemia (Ph+ALL). However, the use of TKIs may decrease the number of collected oocytes during fertility preservation procedures. We report the case of a 19‐year‐old patient with Ph+ALL for whom 21 oocytes were frozen after controlled ovarian stimulation was initiated 2 days after the completion of 28 days of remission induction therapy with dasatinib. After collecting the oocytes, consolidation therapy was initiated immediately, and a hematopoietic stem cell transplant from her younger brother was scheduled. It is believed that a 2‐day withdrawal period is sufficient for fertility preservation or that the effect of dasatinib on the number of oocytes obtained is minimal.
Criminal Justice Contact, Residential Independence, and Returns to the Parental Home
Authors: Warner Cody , Remster Brianna 
Published: January 2021

AbstractObjectiveThe authors investigate whether criminal justice contact is associated with residential transitions—both home‐leaving and home‐returning—among contemporary young adults.BackgroundMore young adults live with their parents today than live independently. Despite the prevalence of criminal justice contact among young Americans, and research suggesting that such contact can reshape the life course, it is unknown whether the criminal justice system is associated with patterns of home‐leaving and home‐returning.MethodData are drawn from the National Longitudinal Survey of Youth 1997, a sample of 8,984 young adults born between 1980 and 1984. Event history analyses are used to examine the timing of home‐leaving (n = 810,274 person‐months), and among those who leave, the timing of home‐returning (n = 630,394 person‐months). Criminal justice contact is measured via self‐reported arrests and spells of incarceration.ResultsAcross both the short term and long term, there is a robust association between criminal justice contact and residential transitions out of and back into the parental home. The risk of experiencing home‐leaving or home‐returning is considerably higher in the month an individual is arrested or completes a spell of incarceration, compared to individuals with no contact. Additionally, especially for arrest, the risk of each residential transition remains elevated in the months and years that follow contact.ConclusionFindings highlight how the criminal justice system may complicate the transition to adulthood by contributing to unstable residential trajectories.
Effect of immunized egg proteins on the performance and neonatal diarrhoea incidence in newborn calves
Authors: van Kuijk Sandra , Kinkead Ruth , Scoley Gillian , Morrison Steven , Han Yanming 
Published: January 2021

AbstractThe aim of this study was to assess the effects of feeding immunized egg proteins (IEP) on the health and performance of newborn dairy calves. Sixty‐four Holstein calves, both male and female, were divided over two treatments. Calves either received IEP or a placebo (PCB) in their colostrum and calf milk replacer (CMR) for the first 14 days of their life. Until day 49, CMR was offered at 15% of birth weight (BW), at 10% on days 49–57 and at 5% on days 57–63. In addition, calves received starter concentrate, chopped straw and water from 3 days old until 70 days old at the end of study. Individual CMR and concentrate intake were measured daily whilst BW was recorded weekly. Visual faecal scoring and health observations were conducted daily. Faecal samples were collected weekly up to 4 weeks and during the first 4 days of scouring to screen for presence ofCryptosporidium parvum, rotavirus, coronavirus,E. coliandSalmonella. Results indicated that feeding IEP increased BW (p < .05) at 42 and 56 days old, and BW also tended (p = .06) to be higher after weaning at 63–70 days old compared to the PCB group. When analysed using a repeated measures model, compared to feeding PCB, feeding IEP increased total concentrate consumption (p = .001) by 3.6kg/calf. Over the entire study, daily water intake was higher (p = .002) for the IEP group when compared with the PCB group. In the IEP group, 12 calves were scored as scouring whereas there were 14 calves in the PCB group. There were no significant differences between treatments in faecal pathogen load of neither healthy nor scouring calves. In conclusion, supplementing IEP during the first 14 days of calf life improved the performance of newborn calves. Further work is warranted to understand the mode of action of IEP in calves.
Stable isotope analysis suggests low trophic niche partitioning among co‐occurring land snail species in a floodplain forest
Authors: Němec T. , Líznarová E. , Birkhofer K. , Horsák M. 
Published: January 2021

AbstractLand snails are abundant invertebrates in many terrestrial ecosystems, playing an essential role in food webs and nutrient cycling. Although snails are commonly considered general grazers with a strong tendency to omnivory, their foraging strategy is well documented only for a few species. Virtually no data exist on trophic niche partitioning within snail assemblages. To fill this gap, we analyzed naturally occurring stable isotope (δ13C, δ15N), an approach widely applied in ecological research, but only rarely in terrestrial snail studies. We collected ten individuals of the dominant co‐occurring land snails (i.e.,Aegopinella nitidula,Fruticicola fruticum,Oxyloma elegans,Succinea putris,Trochulus villosulusandZonitoides nitidus) in a floodplain forest floor, along with their potential food sources and other invertebrates. All species, except forA. nitidula, showed high intraspecific variation in isotope signatures, indicating their opportunistic feeding behavior. Such a high intraspecific variation combined with the active movement range of all the species allows switching between food sources based on their accessibility. We observed that the trophic niches of the studied species highly overlapped, except forZ. nitidus. This suggests that trophic niche compartmentalization among co‐occurring species does not seem to be the mechanism to avoid competition for food. Virtually unlimited resources for snail food are assumed to explain the coexistence of many species in high‐density populations. Our results add to this concept of assembly rules in snail species by the finding of highly variable and overlapping trophic niches among the majority of the studied species.
A Keynesian model of aggregate demand in the long‐run
Authors: McDonald Ian M. 
Published: January 2021

AbstractThis paper develops the Keynesian theory of aggregate demand in the long‐run in which persistently low levels of aggregate demand can generate persistently low levels of activity with the associated persistently high rates of unemployment. Wages are determined by firm‐worker bargaining/sharing. Investment is influenced by monopoly power, aggregate demand and the interest rate. Decreasing rates of deflation of money wages and prices even at high rates of unemployment are prevented by workers being assumed to be loss averse with respect to reductions in their wages below a reference real wage.
Viral inosine triphosphatase: A mysterious enzyme with typical activity, but an atypical function
Authors: James Amy M. , Seal Susan E. , Bailey Andy M. , Foster Gary D. 
Published: January 2021

AbstractPlant viruses typically have highly condensed genomes, yet the plant‐pathogenic viruses Cassava brown streak virus, Ugandan cassava brown streak virus, and Euphorbia ringspot virus are unusual in encoding an enzyme not yet found in any other virus, the “house‐cleaning” enzyme inosine triphosphatase. Inosine triphosphatases (ITPases) are highly conserved enzymes that occur in all kingdoms of life and perform a house‐cleaning function by hydrolysing the noncanonical nucleotide inosine triphosphate to inosine monophosphate. The ITPases encoded by cassava brown streak virus and Ugandan cassava brown streak virus have been characterized biochemically and are shown to have typical ITPase activity. However, their biological role in virus infection has yet to be elucidated. Here we review what is known of viral‐encoded ITPases and speculate on potential roles in infection with the aim of generating a greater understanding of cassava brown streak viruses, a group of the world's most devastating viruses.