bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of Sociodemographic and Clinical Factors with Late Presentation for Early Infant HIV Diagnosis (EID) Services in Kenya
Authors: Langat Agnes , Callahan Tegan , Yonga Isabella , Ochanda Boniface , Waruru Anthony , Ng'anga Lucy , Katana Abraham , Onyango Brian , Singa Benson , Oyule Stephen , Githuka George , Omoto Lennah , Muli Jane , Tylleskar Thorkild , Modi Surbhi 
Published: December 2021

Background: Understanding the missed opportunities in early infant HIV testing within the PMTCT program is essential to address any gaps. The study set out to describe the clinical and sociodemographic characteristics of the infants presenting late for early infant diagnosis in Kenya.
Methods: We abstracted routinely collected clinical and sociodemographic characteristics, in a cross-sectional study, on all HIV-infected infants with a positive polymerase chain reaction (PCR) test from 1,346 President’s Emergency Plan for AIDS Relief (PEPFAR) supported health facilities for the period October 2016 to September 2018. We used multivariate logistic regression to examine the association of sociodemographic and clinical characteristics with late (>2 months after birth) presentation for infant HIV testing.
Results: Of the 4,011 HIV-infected infants identified, the median infant age at HIV diagnosis was 3 months [interquartile range (IQR), 1-16 months], and two-thirds [2,669 (66.5%)] presented late for infant HIV testing. Factors that were associated with late presentation for infant testing were: maternal ANC non-attendance, adjusted odds ratio (aOR) 1.41 (95% confidence interval (CI) 1.18 -1.69); new maternal HIV diagnosis, aOR 1.45, (95%CI 1.24 -1.7); and lack of maternal antiretroviral therapy(ART), aOR 1.94, (95% CI 1.64 - 2.30). There was a high likelihood of identifying HIV-infected infants among infants who presented for medical services in the outpatient setting (aOR 18.9; 95% CI 10.2 - 34.9) and inpatient setting (aOR 12.2; 95% CI 6.23-23.9) compared to the infants who presented late in maternity.
Conclusion and Global Health Implications: Gaps in early infant HIV testing suggest the need to increase maternal pre-pregnancy HIV diagnosis, timely antenatal care, early infant diagnosis services, early identification of mothers who seroconvert during pregnancy or breastfeeding and improved HIV screening in outpatient and inpatient settings. Early referral from the community and access to health facilities should be strengthened by the implementation of national PMTCT guidelines.

Copyright © 2021 Langat et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0.
Development of the knowledge test of medical instruments and materials for cancer chemotherapy
Authors: Tanabe Kouichi , Nitta Atsumi , Origasa Hideki , Nishitani Miyuki , Yatsuduka Miki , Yasuda Tomomi , Yasuda Hatsuna , Hosoya Kenichi 
Published: December 2021

Abstract
Background: Focusing on medical instruments and materials used for high-risk medicines for cancer treatments, a test on knowledge of medical instruments requiring acquisition of basic knowledge and materials was developed for students in pharmacy school. The aim of the study is to investigate the reliability and validity of the test (medical instruments and materials for cancer treatment-Questionnaire 45; MIMCT-Q45) we developed.Patients and Methods: Focus group discussion was performed by participants consisting of medical staff considered to have abundant experience of cancer chemotherapy. Content analysis was performed and a list of extracted medical instruments and materials was prepared. A questionnaire survey was performed twice in pharmacy students to confirm reliability employing the retest method. Responses were also collected from nurses and pharmacists to investigate discriminative validity on comparison with the students. Furthermore, difficulty and discrimination were estimated using the item response theory (IRT).Results: Thirteen types of medical instruments and materials were extracted and listed in the knowledge test. In the questionnaire survey, the overall Cronbach’s α and interclass correlation coefficient were high, but Cronbach’s α was slightly low (0.56-0.58) in some categories. The range of discrimination estimated based on IRT was 0.98-3.09, and that of difficulty was -0.91-3.00.Conclusions: A knowledge test on cancer chemotherapy-related medical instruments and materials including palliative care at home (MIMCT-Q45) was prepared, and its reliability and validity were confirmed. MIMCT-Q45 might serve as a guidance on basic knowledge to be acquired by students and resident pharmacists and be useful to confirm the level of acquired knowledge.
Real-world Data Analysis of Immunotherapy in Advanced Lung Cancer
Authors: Sun Meiling , Ji Huaijun , Xu Ning , Jiang Peng , Qu Tao , Li Yu 
Published: December 2021

Abstract
BackgroundThis study was designed to investigate the clinical application, efficacy, and safety of immune checkpoint inhibitors (ICIs) in the treatment of lung cancer in the real world. MethodsA retrospective, observational analysis was conducted on patients treated with ICIs in four tertiary hospitals in the region from January 2015 to March 2021, to evaluate the clinical efficacy of ICI single-agent or combined chemotherapy and anti-vascular drugs in the first-line or second-line treatment of patients with advanced lung cancer. ResultsThree hundred and fifteen patients were enrolled in this study. The objective response rate (ORR) and disease control rate (DCR) were 36.5% (115/315) and 94.0% (296/315), respectively, the median progression-free survival (PFS) was 10.8 months, and the median overall survival (OS) was not reached. A total of 165 patients received ICI as the first-line treatment, the median treatment cycle was 8 cycles (2-20 cycles), the short-term efficacy ORR was 41.2%, DCR was 94.5%, and the median PFS was 12.0 months. 150 patients received ICI treatment as second-line treatment, the median treatment cycle was five cycles (2-10 cycles), the short-term efficacy ORR was 31.3%, DCR was 93.3%, and the median PFS was 10.0 months. There were no statistically significant differences in ORR, DCR, or median PFS with ICI as the first-line treatment compared with the second-line treatment(P>0.05). The results of subgroup analysis showed that Karnofsky performance status (KPS) score, EGFR mutation status, and number of treatment lines were not correlated with median PFS((P>0.05). However, there were statistically significant differences in programmed death-ligand 1(PD-L1) expression, pathological types, hormone interference, and antibiotic (Abx) treatment among all groups (P< 0.05). In terms of safety, the overall incidence of adverse reactions in 315 patients was 62.5%, and the incidence of immune-related adverse events(irAEs) was 13.7%. Grade 1-2 and 3-4 incidence of adverse events were 34.9% and 27.65%, respectively. There were four patients who experienced fatal irAEs, two cases were liver damage leading to liver failure, one case was immune related pneumonia, and one case was immune related myocarditis. ConclusionIn the real world, immunotherapy has a good effect on patients with advanced lung cancer and significantly improves ORR and PFS.
Effect of Low-dose Lidocaine on Motor Evoked Potentials in Patients Undergoing Intracranial Tumor Resection With Propofol Anesthesia
Authors: Liu Meijuan , Wang Ning , Wang Dong , Liu Juan , Jin Wenjie 
Published: December 2021

Abstract
ObjectTo investigate the effect of low-dose lidocaine on motor evoked potentials (MEP) in patients undergoing intracranial tumor resection with propofol anesthesia.MethodsForty patients undergoing intracranial tumor resection and required MEP monitoring were selected.They were randomly divided into the lidocaine group (Group L, n=20) and control group (Group C, n=20) by computer generated randomization. All patients were given propofol anesthesia under the guidance of bispectral index (BIS).In Group L, lidocaine 1 mg/kg was injected intravenously during anesthesia induction. Then, lidocaine was continuously pumped at the speed of 1 mg/kg·h until the operation start. Group C was given the equal volume of normal saline. Heart rate (HR), mean artery pressure (MAP), and BIS were recorded before anesthesia induction (T0), 2 min after tracheal intubation (T1), 35 min (T2) and 50 min (T3) after anesthesia induction. The amplitude and latency of MEP at T2 and T3, the total dosage of propofol, and adverse events before T3 were recorded.ResultsCompared with Group C, HR and MAP were significantly decreased at T1 in Group L. No significant difference was observed in HR and MAP at T0, T2 and T3 between Group L and Group C. The total dosage of propofol and the incidence of adverse events were significantly lower in Group L than in Group C before T3. There was no significant difference in the amplitude and latency of MEP between the two groups at each time point.ConclusionLow-dose lidocaine has no effect on MEP in patients undergoing intracranial tumor resection. In addition, it increased hemodynamic stability, reduced propofol use, and decreased the incidence of adverse events.
Risk of Developing Depression among Breast Cancer Patients in Palestine
Authors: Sadaqa Dana , Farraj Ahlam , Naseef Hani , Alsaid Hamza , Alshami Nimeh , Abukhalil Abdallah 
Published: December 2021

Abstract
Background: Breast cancer (BC) is the most common cancer among women. Studies have shown that cancer patients can develop depression impacting their quality of life, treatment outcomes, and survival rates. This study aimed to determine the risk factors, severity and prevalence of depression among females diagnosed with BC in multiple hospitals across Palestine.Methods: a cross-sectional study was conducted at different cancer treatment centers in Palestine using a previously developed questionnaire consisting of 23 questions to assess the severity of major depressive disorder among females diagnosed with breast cancer. The Patient Health Questionnaire-9 (PHQ-9) was included in the questionnaire. Results: Out of 223 respondents, 79 (35.4%) have developed moderate to severe depression. Chi-square results revealed that the risk of developing moderate to severe depression was higher among females who suffer from side-effects related to BC treatment (P<0.011), females who knew the BC stage at the diagnosis step (P<0.031), and negative implications on BC patients in Palestine (P<0.009).Conclusion: Breast cancer patients have an increased risk of developing major depressive disorder. Patient assessment and treatment for depression at the time of BC diagnosis, during the treatment journey, and monitoring after treatment completion is essential for patient quality of life and BC treatment outcomes.
Study of Prevalence and Characteristics of Long Covid in Spanish Children
Authors: Bergia María , Sanchez-Marcos Elena , Gonzalez-Haba Blanca , Hernaiz Ana Isabel , de Ceano-Vivas María , López-Hortelano Milagros García , García María Luz García , Jimenez-García Raquel , Calvo Cristina 
Published: December 2021

Abstract
ObjectivesProlonged symptoms after acute COVID-19 have been described in the pediatric population. Our objective was to know the prevalence of prolonged symptoms in children with confirmed SARS-CoV-2 infection, and to describe their clinical characteristics and possible risk factors.Patients & methodsMulticentre retrospective study carried by telephone questionnaire of all children under 18 years old diagnosed of symptomatic COVID-19, both hospitalized and outpatient attended in three hospitals in Spain between March and December 2020. Long-COVID was defined as the presence of symptoms longer than 12 weeks. A control group of children attended by other causes was also contacted and compared.Results451 children met criteria and agreed to participate; 370/451 (82%) presented mild outpatient infection, and 23 required admission in PICU (5.1%). The mean age was 5.9 years old (SD 5.3). A control group of 98 children was included.In 66 cases (14.6%) at least one symptom lasted longer than 12 weeks. Insomnia, concentration problems, apathy or sadness and anxiety were the longest (median >90 days). Age above 5 years (48/66; 72.7%, OR: 3, CI 95% (1.8-5)); admission (OR 3.9 CI 95% (2.2-6.8)), the need for PICU (OR 4.3 CI 95% (1.8-10.4)), and to have a relative with prolonged symptoms (OR 2.8 CI 95% (1.5-5.2)) were significantly associated with Long-COVID. When comparing with controls age above 5 years old, myalgia, asthenia, and loss of appetite were significantly associated with Long-COVID.ConclusionsOur study shows that children also suffer prolonged symptoms after COVID-19 infection, and require specific attention.
Urban Flooding Risk Assessment Based on Numerical Simulation of Sub-catchment Area: A Case Study From Chengdu, China
Authors: Ying Xuejin , Ni Ting , Lu Mingxia , Li Zongmin , Lu Yi , Bamisile Olusola 
Published: December 2021

Abstract
Urbanization and climate change usually result in frequent urban flooding. Since the floods cannot be avoided, the scenario simulation combined with risk analysis is an effective way to assess the disaster level and reduce direct damage loss when facing the emergency management problems. Different from the whole city dimension, the paper proposed a sub-catchment multi-index hesitant fuzzy evaluation model for the community planning level, and takes Jinjiang District of Chengdu city as the research object. Firstly, based on the PSR (Pressure-State-Response) model, the risk assessment system has been established in three aspects, including the current situation of urban drainage, the basic geographic information, and the social influence. Secondly, A total of 14 evaluation indexes were selected, among which the pressure index came from the calculation results of ArcGIS and EPASWMM5 model such as runoff coefficient, maximum water depth, etc. Thirdly, the expert hesitate fuzzy evaluation method was used to obtain the weight of 14 indexes of each sub-catchment. Finally, the 224 evaluation results were compared, and the urban flooding disaster risk map has been drawn. It is mainly concluded that 160 medium-higher risk areas were mainly concentrated in high built-up area in study area. Furthermore, the evaluation model is very useful as a decision-making tool for mitigation of the flood hazard and its associated risk.
Outcomes and Risk Factors for Failed Trial of Labor After Cesarean Delivery (TOLAC) in Women with One Previous Cesarean Section: A Chinese Population-Based Study
Authors: He Xiaobo , Dai Qiaona , Wu Xiaoli , Zhou Junjun , Li Jie 
Published: December 2021

Abstract
Background

To evaluate the outcomes and risk factors for trial of labor after cesarean delivery (TOLAC) failure in patients in China.
Methods

Consecutive patients who had a previous cesarean delivery (CD) and were scheduled for TOLAC were included from 2014 to 2020. Patients who successfully delivered were classified into the TOLAC success group. Patients who were scheduled for TOLAC and had a repeat CD due to medical issues were classified into the TOLAC failure group. Multiple logistic regression analyses were performed to examine the risk factors for TOLAC failure.
Results

In total, 720 women who had a previous CD and were scheduled for TOLAC were identified and included. The success rate of TOLAC was 84.17% (606/720). Seven patients were diagnosed with uterine rupture, none of whom underwent hysterectomy. Multiple logistic regression analysis showed that the gestational weeks at pregnancy termination (odds ratio [OR] = 3.046, 95% confidence interval [CI]: 0.962-9.642, P = 0.005) and induction of labor (OR = 2.843, 95% CI: 1.571-5.145, P = 0.001) were positively associated with TOLAC failure. In contrast, the thickness of the lower uterine segment (LUS) (OR = 0.215, 95% CI: 0.103-0.448, P = 0.001) was negatively related to TOLAC failure.
Conclusions

This study suggests that TOLAC is effective in decreasing CD rates in the Chinese population. The gestational weeks at pregnancy termination and induction of labor were positively associated with TOLAC failure. Our findings need to be confirmed in larger samples with patients of different ethnicities.
Characterization and Prediction of Dengue Virus Targeting Peptides Based on Combined Amino Acid Composition Descriptors Using Random Forest Algorithm.
Authors: Elumalai Elakkiya , Muthuvel Suresh Kumar 
Published: December 2021

Abstract
Dengue virus peptides are emerging as potential therapeutics for dengue infection. Due to the important role of dengue peptides in curbing dengue infection, their identification has proven crucial in terms of infection biology. To calculate differences between amino acids and physiochemical attributes, statistical tests and F-scores were used in this work. The random forest algorithm was used to predict dengue peptides using grouped amino acid composition, transition and distribution. Here, we have used three descriptors; Amino acid content, Grouped Amino acid composition and Composition, transition and distribution features (CTDC). We have created models and compared with combined model. Using the grouped amino acid composition as input parameters for the random forest algorithm, Our classifier's overall accuracy increased to 88.80%, which was the greatest overall accuracy found in this investigation. Our classifier produced superior predicting outcomes when compared to previously developed algorithms. In conclusion, we looked at the differences in amino acids and physiochemical properties between dengue viral peptides, using the grouped amino acid composition to build a classifier that predicts these dengue virus inhibitory peptides.
Growth, respiratory activity and chlorpyrifos biodegradation in cultures of Azotobacter vinelandii ATCC 12837
Authors: Avila Victoria Conde , Peña Carlos , Armendáriz Beatriz Pérez , Loera Octavio , Valenzuela Carmen Martínez , Leyva Belisario , Bastidas Pedro de Jesús Bastidas , Lugo Holjes Salgado , Ortega Luis Daniel 
Published: December 2021

Abstract
This study aimed to evaluate the growth, respiratory activity, and biodegradation of chlorpyrifos in cultures of Azotobacter vinelandii ATCC 12837. A strategy based on the modification of culture media and aeration conditions was carried out to increase the cell concentration of A. vinelandii , in order to favor and determine its tolerance to chlorpyrifos and its degradation ability. The culture in shaken flasks, using sucrose as a carbon source, significantly improved the growth compared to media with mannitol. When the strain was cultivated under oxygen-limited (5.5, 11.25 mmol L- 1 h- 1 ) and no-oxygen-limited conditions (22 mmol L -1 h -1 ), the growth parameters were not affected. In cultures in a liquid medium with chlorpyrifos, the bacteria tolerated a high pesticide concentration (500 ppm) and the growth parameters were improved even under conditions with a reduced carbon source (sucrose 2 g L -1 ). The strain degraded 99.6 % of chlorpyrifos at 60 h of cultivation, in co-metabolism with sucrose; notably, A. vinelandii ATCC 12837 reduced by 50% the initial pesticide concentration in only 6 h (DT 50 ).
NOTCH4 Single-Nucleotide Polymorphism Is Associated With Brain Arteriovenous Malformation in a Chinese Han Population
Authors: Zhang Jianbo , Li Zhenjun , Fan Haiyan , Su Hengxian , Meng Hongliang , Zhang Xin , Li XiFeng , Duan Chuanzhi , He Xuying , Zhong Ming , Liu Ziying 
Published: December 2021

Abstract
Background: Brain arteriovenous malformations (BAVMs) are high-flow intracranial vascular malformations characterized by the direct connection of arteries to veins without an intervening capillary bed. It is one of the main causes of intracranial hemorrhage and epilepsy though morbidity is low. Angiogenesis, heredity, inflammation, and arteriovenous malformation syndromes play important roles in BAVM formation. Animal experiments and previous studies have confirmed that NOTCH4 may be associated with BAVM development. Our study identifies a connection between NOTCH4 gene polymorphisms and BAVM in a Chinese Han population.Methods: We enrolled 150 patients with BAVMs confirmed by digital subtraction angiography (DSA) in the Department of Neurosurgery, Zhujiang Hospital, Southern Medical University from June 2017 to July 2019. Simultaneously, 150 patients without cerebrovascular disease were confirmed by computed tomography angiography/magnetic resonance angiography/DSA. DNA was extracted from peripheral blood and NOTCH4 genotypes were identified by PCR-ligase detection reaction. Chi-square test or Fisher’s exact test was used to evaluate the difference in allele and genotype frequencies between the BAVM group, control group, bleeding, and other complications.Results: Two single-nucleotide polymorphisms (SNPs), rs443198 and rs438475, were significantly associated with BAVM. No SNP genotypes were significantly associated with hemorrhage and epilepsy. SNPs rs443198_ AA-SNP and rs438475_ AA-SNP may be associated with lower risk of BAVM (P = 0.011, OR = 0.459, 95% CI 0.250–0.845; P = 0.033, OR = 0.759, 95% CI 0.479–1.204).Conclusion: NOTCH4 gene polymorphisms were associated with BAVM and may be a risk factor in a Chinese Han population.
Impacts of Fracture Roughness and Near-wellbore Tortuous on Proppant Transport Within Hydraulic Fractures
Authors: Wang Di , Bai Bingyang , Wang Bin , Wei Dongya , Liang Tianbo 
Published: December 2021

Abstract
For unconventional reservoirs hydraulic fracturing design, a greater fracture length is a prime factor to optimize. However, core observation results from Hydraulic Fracturing Test Site (HFTS) show the propped fractures are far less or shorter than expected which suggests the roughness and tortuous of hydraulic fractures are crucial to sand transport. In this study a transport model of sands is first built based on experimental measurements on the height and transport velocity of sand bank in fractures with predetermined width and roughness. The fracture roughness is quantified by using surface height integral. Then, three-dimensional simulations are conducted with this modified model to further investigate the impact of fractures tortuous on sand transport, from which an analytical model is established to estimate the propped length of hydraulic fractures at a certain pumping condition. Experiments results show that height of sand bank in roughness fracture is 20-50% higher than that in smooth. The height of sand bank decreases with the reduction of slurry velocity and increases with the sand diameters increasing. Sand sizes do little effect on the transport velocity of sand bank but the increase in slurry velocity and sand volume fraction can dramatically enhance the migration velocity of sand bank. The appearance of tortuous decreases the horizontal velocity of suspended particles and results in a higher sand bank compared with that in straight fractures. When the sand bank gets equilibrium at the tortuous position, it is easy to produce vortices. So, there is a significant height of sand bank change at the tortuous position. Moreover, sand plugging can occur at the entrance of the fractures, making it difficult for the sand to transport deep in fractures. This study explains why the propped length of fractures in HFTS is short and provides an analytical model that can be easily embedded in the fracturing simulation to fast calculate dimensions of the propped fractures network to predict length and height of propped fractures during fracturing.