bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laryngeal mask airway protector generates higher oropharyngeal leak pressures compared to the laryngeal mask airway supreme
Authors: Acx Emilie , Van Caelenberg Els , De Baerdemaeker Luc , Coppens Marc 
Published: July 2021

Background and Aims:
The Laryngeal Mask Airway (LMA) Protector™ is one of the latest introduced supraglottic airway devices. It provides access and functional separation of the respiratory and digestive tracts. Compared to the LMA Supreme™, it has two digestive ports, one to provide suction in the pharyngeal region and one for gastric tube insertion. High oropharyngeal leak pressure is a marker for safe ventilation when using LMA devices. We hypothesized that oropharyngeal leak pressure of the LMA Protector™ is 5 cm H2O higher than the oropharyngeal leak pressure of the LMA Supreme™ at various cuff volumes. Secondary outcome measures were ease of insertion of both masks, fiberoptic confirmation of correct positioning, failures of insertion, presence of blood staining, sore throat, presence of air leak and insertion time.

Material and Methods:
American Society of Anesthesiologists (ASA) I-III patients aged >18 years, scheduled for elective minor ambulatory surgery under general anesthesia with a LMA were included. Patients were randomized in the LMA Protector™ or LMA Supreme™ group based on a computer-generated random sequence table. After general anesthesia induction, oropharyngeal leak pressures were measured.

Results:
Oropharyngeal leak pressures were significantly higher (P < 0.0001) for LMA Protector™ compared to LMA Supreme™ at different cuff volumes and a cuff pressure of 65 cm H2O. Insertion time was significantly higher for the LMA Protector™ (29 sec) [interquartile range (IQR) 23, 35] compared to the LMA Supreme™ (19 sec) (IQR 16, 22) (P < 0.0001). There were no statistically significant differences in ease of insertion (number of attempts for succesful positioning), failures of insertion, presence of blood staining, sore throat or presence of air leak.

Conclusion:
Oropharyngeal leak pressures were consistently higher (>5 cm H2O) for LMA Protector™ compared to LMA Supreme™. LMA Protector™, therefore, allows effective ventilation at higher airway pressures than LMA Supreme™.

Trial Registration:

http://clinicaltrials.gov.NCT03462550.
A randomized control led study comparing CMAC video laryngoscope and Macintosh laryngoscope for insertion of double lumen tube in patients undergoing elective thoracotomy
Authors: Mathew Amit , Chandy Jacob , Punnoose Joseph , Gnanamuthu Birla Roy , Jeyseelan L. , Sahajanandan Raj 
Published: July 2021

Background and Aims:
Double lumen tube (DLT) insertion for isolation of lung during thoracic surgery is challenging and is associated with considerable airway trauma. The advent of video laryngoscopy has revolutionized the management of difficult airway. Use of video laryngoscopy may reduce the time to intubate for DLTs even in patients with normal airway.

Material and Methods:
A total of 87 ASA 1–3 adults, scheduled to undergo elective thoracotomy, requiring a DLT were randomly allocated to videolaryngoscope (CMAC) arm or Macintosh laryngoscope arm. It was on open label study, and only the patient was blinded. The primary objective of this study was to compare the mean time taken for DLT intubation with CMAC (Mac 3) and Macintosh laryngoscope blade and the secondary objectives included the hemodynamic response to intubation, the level of difficulty using the intubation difficulty scale (IDS), and complications associated with intubation. Data was analysed using the statistical software SPSS (version 18.0).

Results:
The time taken for intubation was not significantly different (42.8 ± 14.8 s for CMAC and 42.5 ± 11.5 s for Macintosh laryngoscope P -0.908). The CMAC video laryngoscope was associated with an improved laryngoscopy grade (Grade I in 81.8% with CMAC and in 46.5% with Macintosh), less pressure applied on the tongue, and less external laryngeal pressure required. Hemodynamic responses to intubation were similar in both groups.

Conclusion:
Macintosh blade is as good as CMAC (mac 3) blade to facilitate DLT intubation in adult patients with no anticipated airway difficulty, however CMAC was superior as it offers better laryngoscopic view, needed less force, and fewer external laryngeal manipulations.
Retinal Vascular Abnormalities in Different Types of Inherited Retinal Dystrophies Assessed by Optical Coherence Tomography Angiography
Authors: Sabbaghi Hamideh , Daftarian Narsis , Hassanpour Kiana , Fekri Sahba , Nourinia Ramin , Suri Fatemeh , Kheiri Bahareh , Yaseri Mehdi , Rajabpour Mojtaba , Sheibani Kourosh , Ahmadieh Hamid 
Published: July 2021

Purpose:
To investigate the retinal vascular characteristics among patients with different types of inherited retinal dystrophies (IRDs).

Methods:
This comparative cross-sectional study was conducted on 59 genetically confirmed cases of IRD including 37 patients with retinitis pigmentosa (RP) (74 eyes), 13 patients with Stargardt disease (STGD) (26 eyes), and 9 patients with cone-rod dystrophy (CRD) (18 eyes). Both eyes of 50 age- and sex-matched healthy individuals were investigated as controls. All participants underwent optical coherence tomography angiography to investigate the vascular densities (VDs) of superficial and deep capillary plexus (SCP and DCP) as well as foveal avascular zone area.

Results:
In RP, significantly lower VD in whole image (P = 0.001 for DCP), fovea (P = 0.038 for SCP), parafovea (P < 0.001 for SCP and DCP), and perifovea (P < 0.001 for SCP and DCP) was observed compared to controls. In STGD, VD of parafovea (P = 0.012 for SCP and P = 0.001 for DCP) and fovea (P = 0.016 for DCP) was significantly lower than controls. In CRD, the VD of parafovea (P = 0.025 for DCP) was significantly lower than controls. Whole image density was significantly lower in RP compared to STGD (P < 0.001 for SCP) and CRD (P = 0.037 for SCP). VD in parafovea (P = 0.005 for SCP) and perifovea (P < 0.001 for SCP and DCP) regions was significantly lower in RP compared with STGD. Also, foveal VD in STGD was significantly lower than RP (P = 0.023 for DCP).

Conclusion:
Our study demonstrated lower VDs in three different IRDs including RP, STGD, and CRD compared to healthy controls. Changes were more dominant in RP patients.
Serous Retinal Detachment Resolution Following Trabeculectomy in a Patient with Sturge–Weber Syndrome
Authors: Barbosa Gabriel Castilho Sandoval , Susanna Bianca Nicolela , Okuno Regis Kassai , Junior Remo Susanna 
Published: July 2021

Purpose:
To report a case of Sturge–Weber syndrome (SWS) complicated with uncontrolled glaucoma and serous retinal detachment (SRD) in the left eye that evolved with complete resolution after trabeculectomy.

Methods:
We report the case of a 10-year-old boy with SWS complicated with uncontrolled glaucoma and SRD in the left eye. In primary evaluation, he presented with a left-sided nevus flammeus affecting upper eyelid and best corrected visual acuity of 20/50 on the affected eye. Fundus examination revealed glaucomatous optic nerve neuropathy and diffuse choroidal hemangioma with overlying SRD, which were confirmed with spectral domain optical coherence tomography. Right eye was unremarkable.

Results:
The patient underwent trabeculectomy with mitomycin-C on the affected eye. Two weeks later, he presented with normalization of the intraocular pressure and substantial resolution of subretinal fluid (SRF), which improved to complete resolution of the SRD at 2 months of follow-up. In addition, there was an improvement of visual acuity from 20/50 to 20/40.

Conclusion:
This is the first report to describe a case of SWS associated with SRD and resolution of SRF after trabeculectomy.
Prepapillary Arterial Loop Associated with Central Retinal Artery Occlusion
Authors: Susanna Bianca Nicolela , Barbosa Gabriel Castilho Sandoval , de Almeida Luciana , Neto Julio Zaki Abucham 
Published: July 2021

Purpose:
To report a case of central retinal artery (CRA) occlusion secondary to prepapillary loop in a 13-year-old girl.

Methods:
A 13-year-old girl presented with a history of sudden visual loss in her left eye.

Results:
Fundus examination confirmed thrombosis in a prepapillary arterial loop causing CRA occlusion and extensive retinal ischemia. Macular region was watered by an anomalous macular branch, which explained her 20/20 vision central vision.

Conclusion:
Congenital prepapillary vascular loops are rare and usually asymptomatic. We report a case of central artery occlusion confirmed by multimodal imaging.
Characteristics of Central Serous Chorioretinopathy without Leakage
Authors: Parameswarappa Deepika C , Maltsev Dmitrii S , Goud Abhilash , Singh Sumit Randhir , Chhablani Jay 
Published: July 2021

Purpose:
To describe optical coherence tomography (OCT) characteristics of central serous chorioretinopathy (CSCR) without any hyperfluorescent leakage on fundus fluorescein angiography (FFA).

Methods:
This was a multicentric, retrospective, observational study of ten eyes of ten patients with CSCR without any hyperfluorescence leakage on FFA. Baseline patient characteristics, best corrected visual acuity, and OCT parameters like relative retinal pigment epithelium (RPE) reflectivity at the presumed leak site and control site were measured.

Results:
Increased macular thickness, neurosensory detachment, and choroidal thickness were seen at the site of maximum subretinal fluid (SRF). Out of ten eyes, nine had photoreceptor outer segment (PROS) disruption (46% ± 26.33%) at the site of SRF pocket, and five had presumed former leak site characterized by PROS thinning. The presumed leak site demonstrated higher RPE reflectivity compared to the control site (0.92 ± 0.04 vs. 0.87 ± 0.04; P = 0.0058).

Conclusion:
CSCR without hyperfluorescent leakage on FFA may have PROS damage and changes in RPE hyperreflectivity.
ИССЛЕДОВАНИЕ ВЛИЯНИЯ РЕЖИМОВ ТЕПЛОВОЙ ОБРАБОТКИ
СОУСОВ НА СОДЕРЖАНИЕ ВИТАМИНА С ДЛЯ ФИРМЕННОГО
БЛЮДА «ЗОЛОТО БАЛТИКИ»
Authors: Горшкова А.В. , Белова М.П. 
Published: July 2021

В статье приведены результаты исследования по установлению режима тепловой обработки облепихового соуса к фирменному блюду «Золото Балтики», при котором происходит максимальное сохранение экстрагируемого витамина С. Показана технологическая схема
фирменного блюда и его схематическое представление. Обоснован выбор ингредиентов рецептуры для облепихового соуса. Определено количество витамина С в замороженной облепихе, не подвергшейся тепловой обработке, что составляет 96 % от количества аскорбиновой кислоты в свежих плодах. Рассчитаны потери аскорбиновой кислоты при выбранных режимах тепловой обработки, количество витамина С в порции соуса и процент удовлетворения суточной потребности в данном витамине. Доказано, что порция облепихового соуса (30 г) обеспечивает суточную потребность в витамине С для взрослого человека на 42,6 %.
РАЗРАБОТКА ТЕХНОЛОГИИ КАРАМЕЛИ С НАЧИНКОЙ
ПОВЫШЕННОЙ ПИЩЕВОЙ ЦЕННОСТИ
Authors: Павлова Э.С. , Землякова Е.С. 
Published: July 2021

Представлен способ приготовления карамели с начинкой, обогащенной
биологически активными веществами растений, которые способствуют укреплению
иммунитета за счет содержания витамина С и биофлавоноидов.
В статье представлены результаты исследования предпочтений жителей
г. Калининграда и Калининградской области при выборе кондитерских изделий. Путем
моделирования и оптимизации рецептуры и параметра процесса экстрагирования
определены оптимальные значения факторов, влияющих на процесс приготовления
карамели с начинкой. Приведены данные оценки качества готового продукта по
органолептическим и физико-химическим показателям, произведен расчет показателей,
повышающих его пищевую ценность. Разработаны профилограммы вкуса и запаха для
нового продукта.
Epidemiología delcáncer de ovario en el hospital nacional de clínicas. Universidad nacional de córdoba, 2014-2020.
Authors: Guerrero Claudia , Pelliccioni Patricia , Brunotto Mabel Brunotto , Imahorn Julieta , Saavedra Natalia , Ruggieri María E , Cabalier María Elisa Dionisio 
Published: July 2021

Introducción: El objetivo del presente trabajo fue describir características anatomopatológicas, imagenológicas y clínicas de pacientes diagnosticadas de cáncer de ovario (CO) del Hospital Nacional de Clínicas (HNC) dependiente de la Universidad Nacional de Córdoba (UNC) entre 2014 a 2020. Métodos: Estudio retrospectivo, descriptivo. Basado en la revisión de 26 historias clínicas de pacientes diagnosticadas de tumores sólidos de ovario, las muestras se colorearon con técnicas de hematoxilina-eosina y se utilizaron los inmuno marcadores ck7, ck20, EMA, cd20. De este grupo se detectó y estudió un caso con diagnóstico de CO.
Resultados: En la serie de tumores estudiados la mediana etaria correspondió a 63 años. La ocurrencia de CO en este estudio fue 3,8%. La imagenología evidenció compromiso poliorgánico y los subtipos histológicos establecieron el pronóstico. Conclusión: La interpretación de los resultados debe tener en cuenta: clínica, imagenología, histología e inmunohistoquímica. Dado lo complejo del diagnóstico el consejo genético cobra importancia.
Analisis Konsumsi Daya Mobil Listrik Dengan Penggerak Motor Brushed DC
Authors: Hendra Rusaldi , Yadie Erry , Arbain Arbain 
Published: July 2021

Abstrak- Penelitian ini bertujuan untuk menganalisis konsumsi daya pada mobil listrik yang menggunakan mesin penggerak motor brushed DC. Dengan diketahui konsumsi dayanya pada kecepatan konstan tertentu dan kapasitas baterai yang digunakan, maka dapat dihitung jarak maksimum yang dapat ditempuh. Pada penelitian ini digunakan motor Brushed DC 1000 Watt sebagai penggerak utama. Untuk sumber energy digunakan baterai berjenis Lead Acid dengan kapasitas 48 Volt 30 Ampere hour (Ah). Untuk mengendalikan kecepatan digunakan pedal throttle yang menggunakan hall sensor. Keluaran sensor dihubungkan dengan Arduino Uno yang berfungsi untuk mengendalikan rangkaian driver. Untuk mengukur tegangan suplai, konsumsi arus, dan kecepatan motor, masing-masing menggunakan sensor tegangan (opto coupler dan pembagi tegangan), sensor arus (ACS712), dan sensor kecepatan (Phototransistor dan resistor). Hasil pengukuran diproses oleh dua buah Arduino yang kemudian mengirimkan data ke laptop malalui transceiver LoRa. Dengan alat ukur buatan sendiri yang mempunyai toleransi kesalahan di bawah 3 % dibanding alat ukur referensi, diperoleh hasil bahwa untuk mendapat kecepatan konstan 4 m/s diperlukan tambahan daya sebesar 11 % dibanding pada kecepatan 2 m/s. Tetapi dengan kapasitas baterai yang sama, dan tambahan daya 11 % tersebut, jarak yang ditempuh mencapai hampir dua kali lipat yang dapat ditempuh dengan kecepatan 2 m/s.
The impact of T2T therapy on the treatment of the patients with the early rheumatoid arthritis (data from OREL registry)
Authors: Rybakova V. V. , Avdeeva A. S. , Dibrov D. A. , Nasonov E. L. 
Published: July 2021

Aim – to analyze long-term results of intensive treatment initiated at rheumatoid arthritis (RA) onset in real clinical practice.Material and methods. 93 RA patients were included. Subcutaneous MTX was initiated at 10–15 mg per week with further dose escalation up to 20–30 mg per week. If MTX monotherapy did not allow to achieve treatment target of remission or low disease activity, biologics were added.Results. Against the background of observation, there was a significant decrease in the activity of diseases and the level of acute phase indicators, after 12 months of treatment, the values of the DAS28-ESR indices were 2.76 [2; 3.7], SDAI – 5.34 [1.8; 9.7], CDAI – 5 [1.5; 9.5], corresponded to low disease activity; remission was achieved in 48.6%, low activity – in 17.5%, moderate activity remained in 31%, high activity – in 2.7% of patients. After 6 years the median age of patients was 58 [49; 66] years, the disease duration – 84 [79; 89] months, the low disease activity was documented in 21.3%, and remission – in 7.8% of patients. After 6 years, the value of the activity indices was: DAS28 – 4 [3.4; 4.59], SDAI – 15.06 [9.32; 21], CDAI – 15 [9; 21]; remission – in 7.7%, low disease activity – in 21.1%, moderate activity – in 60%, high activity – in 11.1% of patients.Conclusion. Intensive therapy initiated at RA onset demonstrates high effectiveness, allowing to achieve remission/low disease activity in about 30% of patients. Adherence to this strategy allowed to discontinue biologics in and synthetic DMARDs after achieving treatment target.
Statistically based algorithm for differential diagnosis of arthropathies based on quantitative osteoscintigraphy
Authors: Prokhorova E. G. , Shikina E. A. , Zhilyaev G. E. , Zhilyaev E. V. 
Published: July 2021

Background. EULAR experts include osteoscintigraphy of joints in the list of promising methods for the diagnosis of joint diseases. However, the method remains little used in rheumatology in our country.Aim of the study – to develop an algorithm for differential diagnosis for the most common arthropathies based on quantitative osteoscintigraphy.Materials and methods. 3 hours after the injection of pyrophosphate labeled with Tc-99m, scintigraphy of skeletal bones was performed according to the “whole body” program. The joint/adjacent bone uptake ratio was calculated. The CHAID algorithm was used for classification tree constructing.Results. The study included 266 patients aged 46.6±14.3 years, 134 men (50.4%). Axial spondyloarthritis (including ankylosing spondylitis) was diagnosed in 40 patients, peripheral spondyloarthritis (including reactive arthritis) – in 87, rheumatoid arthritis– in 45, osteoarthritis – in 68, psoriatic arthritis – in 26 people. A total of 2279 joints were included in the analysis. A classification tree algorithm for differential diagnosis of arthropathies was constructed. Key indicators for identifying subgroups in the algorithm were the intensity of radiopharmaceutical uptake in the wrist, knee and hip joints. The significance level of differences between the resulting groups at all points of the algorithm branching, taking into account the Bonferroni adjustment, was p=0.001 or less. In the training sample, 51.5% of the observations were correctly classified. According to results of the cross-validation, the expected rate of correct classifications in the actual application of the algorithm is 38.0%.Conclusions. An algorithm for differential diagnosis of the most common inflammatory diseases of the joints has been developed. It allows the use of quantitative osteoscintigraphy data in the diagnosis of arthritis.
Mevalonate kinase deficiency syndrome: Single center experience
Authors: Kozlova A. L. , Bludova V. O. , Burlakov V. I. , Raykina E. V. , Varlamova T. V. , Kurnikova М. А. , Remizov А. N. , Tereshchenko G. V. , Moiseeva А. А. , Dibirova S. А. , Khoreva А. L. , Roppelt А. А. , Rodina Yu. А. , Kuzmenko N. B. , Mukhina А. А. , Каlashnikova Е. I. , Igisheva L. N. , Martynova N. V. , Zhogova О. V. , Zimin S. B. , Barabanova О. V. , Kotova Yu. V. , Novichkova G. А. , Shcherbina А. Yu. 
Published: July 2021

The aimof this study was to analyze the clinical, laboratory and molecular genetic data of 26 patients (15 boys, 11 girls) diagnosed with mevalonate kinase deficiency syndrome (MKD).Subjects and methods. The age of MKD manifestation ranged from 0 to 30.0 months (M – 1.5 months). Clinical manifestations and their severity were extremely diverse: from symptoms resembling Marshall’s syndrome to severe systemic manifestations with respiratory failure, hepatosplenomegaly and pancytopenia.Results/Conclusion. All patients had homozygous/compound-heterozygous mutations in theMVKgene, including 10 newly described variants. In all 20 patients, who have been treated with IL-1 inhibitors long enough to assess the effect of the treatment, drastic improvement of the condition was noted, but only in 17/20 patients achieved full remission.
Long-term results of hip arthroplasty and determination of unfavorable risk factors for early development of osteonecrosis in patients with systemic lupus erythematosus
Authors: Mukhanov V. V. , Makarov S. A. , Makarov M. A. , Popkova T. V. 
Published: July 2021

Aim of the study – to determine the risk factors for the early development of osteonecrosis and to analyze the results of surgical treatment of patients with systemic lupus erythematosus in the long term after total hip arthroplasty.Materials and methods. The study group included 42 patients with systemic lupus erythematosus (SLE) complicated by osteonecrosis (ON) of the femoral head, who underwent 59 total hip arthroplasty (THA) operations. Before surgery and 6–21 years after THA, in order to assess the long-term results of surgical treatment of patients, the following was assessed: activity of the underlying disease – according to the SLEDAI-2K (Systemic Lupus Erythematosus Disease Activity Index 2000); the severity of irreversible changes in internal organs – according to the SLICC/ACR index of damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology); the clinical and functional state of the hip joint – according to the HHS (Harris Hip Score); the intensity of pain syndrome – according to the visual analogue scale (VAS); quality of life (QOL) – using the SF-36 questionnaire. The concentration of antibodies to cardiolipin (aCL) of IgM and IgG isotypes was determined by enzyme-linked immunosorbent assay (normal range – 0.0–10.0 GPL for IgM, 0–7 MPL for IgG).Results. After 6–21 years of follow-up after THA, there was a statistically significant decrease in pain intensity according to VAS, improvement according to the HHS from 40.0±14.9 to 83.3±17.4 points, SLE activity according to the SLEDAI-2K from 0 to 20 points (median – 4 [4; 8] points) before surgery and from 0 to 41 points (median – 0 [0; 4] points) after a long period of observation. There was a pronounced statistically significant positive dynamics for all QOL indicators studied (p≤0.005 in all cases). The most significant changes were found on the scales RE (Role-Emotional), RP (Role-Physical Functioning) and BP (Bodily Pain). The early development of ON was associated with the degree of activity of the underlying disease, the cumulative dose of glucocorticoids, kidney damage and arthritis in the first year from the onset of SLE, as well as hematological disorders and the presence of aCL in the blood serum 3 years before the onset of ON. The total number of complications was 10.2%.Conclusion. Total hip arthroplasty in patients with systemic lupus erythematosus can achieve a statistically significant reduction in pain intensity, increase functional activity and improve their quality of life.