bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of an Integrated Irrigation Water Quality Index (IIWQIndex) model
Authors: Islam Md. Shajedul , Mostafa M. G. 
Published: November 2021

Abstract
There are many irrigation water quality indices used to assess water suitability, despite having limitations. It is therefore imperative to develop a water quality index to evaluate irrigation water more accurately. This study highlights an Integrated Irrigation Water Quality Index (IIWQIndex) using the sub-index and aggregated equations. This proposed index model was improved and updated across four characteristics: the verified desirable and permissible value of parameters, maximum hazard class, and modified rating system of diversified parameters. The proposed IIWQIndex model classified irrigation water into five categories: rejection, poor, moderate, good, and excellent. This model assessed two types of water to justify the model by categorizing the irrigation waters. The calculated results showed that the index values were 75.77 and 36.51, and the water category was ‘good’ and ‘rejected’ for the calcite (Ca–HCO3) and sodic (Na–Cl) water, respectively. This index model also satisfactorily evaluated different types of water datasets of eight geographic locations in the world. The study illustrated that the IIWQIndex evaluated values and water categories were rational and comprehensive at predicting the suitability of irrigation water.
Correlation of Oxidative Stress with Melasma: An Overview
Authors: Katiyar Shweta , Yadav Dhananjay 
Published: November 2021

:
Melasma is a hypermelanotic skin disorder characterized by dark brown macules of symmetrical
sizes and shapes that develop over time. Apart from the multiple etiological factors for melasma, such as hormonal
imbalances, thyroid dysfunction, drugs, and contraceptive pills, a new and significant cause has been discovered:
the effect of oxidative stress. Oxidative stress is the result of disequilibrium between reactive oxygen species
and antioxidants in the cells. It is a key element that can cause skin hypopigmentation or hyperpigmentation.
The physiological significance of reactive oxygen species and its function in skin health are addressed in
this study. The development process and pathophysiology of reactive oxygen species with melasma disorder
are also highlighted and the advantages of integrating antioxidants in clinical and experimental environments
are discussed.
Inhalable Polymeric Micro and Nano-immunoadjuvants for Developing Therapeutic Vaccines in the Treatment of Non-small Cell Lung Cancer
Authors: Dondulkar Ayusha , Akojwar Natasha , Katta Chanti , Khatri Dharmendra K. , Mehra Neelesh K. , Singh Shashi B. , Madan Jitender 
Published: November 2021

:Non-small cell lung cancer (NSCLC) is a leading cause of death in millions of cancer patients. Lack of diagnosis at an early stage in addition to no specific guidelines for its treatment, and a higher rate of treatment- related toxicity further deteriorate the conditions. Current therapies encompass surgery, chemotherapy, radiation therapy, and immunotherapy according to the pattern and the stage of lung cancer. Among all, with a longlasting therapeutic action, reduced side-effects, and a higher rate of survival, therapeutic cancer vaccine is a new, improved strategy for treating NSCLC. Immunoadjuvants are usually incorporated into the therapeutic vaccines to shield the antigen against environmental and physiological harsh conditions in addition to boosting the immune potential. Conventional immunoadjuvants are often associated with an inadequate cellular response, poor target specificity, and low antigen load. Recently, inhalable polymeric nano/micro immunoadjuvants have exhibited immense potential in the development of therapeutic vaccines for the treatment of NSCLC with improved mucosal immunization. The development of polymeric micro/nano immunoadjuvants brought a new era for vaccines with increased strength and efficiency. Therefore, in the present review, we explained the potential application of micro/nano immunoadjuvants for augmenting the stability and efficacy of inhalable vaccines in the treatment of NSCLC. In addition, the role of biodegradable, biocompatible, and non-toxic polymers has also been discussed with case studies.
Interleukin-6: Important Mediator of Vasospasm Following Subarachnoid
Hemorrhage
Authors: Lucke-Wold Brandon , Hosaka Koji , Dodd William , Motwani Kartik , Laurent Dimitri , Martinez Melanie , Hoh Brian 
Published: November 2021

:
The correlation of neuroinflammation with the development of cerebral vasospasm following
subarachnoid hemorrhage has been well documented in the literature; both clinical and preclinical.
The exact mechanisms by which this process occurs, however, are poorly elucidated. Recent
evidence indicates that interleukin-6 is not only an important prognostic biomarker for
subarachnoid hemorrhage and subsequent vasospasm development but also an integral component
in the progression of injury following initial insult. In this review, we briefly highlight other pathways
under investigation and focus heavily on what has been discovered regarding the role of interleukin
6 and cerebral vasospasm following subarachnoid hemorrhage. A proposed mechanistic
pathway is highlighted in written and graphical format. A discussion regarding the human correlative
findings and initial pre-clinical mechanistic studies is addressed. Finally, in the future investigation
section, innovative developments and a clear description of areas warranting further scientific
inquiry are emphasized. This review will catalyze continued discovery in this area of emerging
significance and aid in the quest for effective vasospasm treatment where limited clinical therapeutics
currently exist.
Plasma Apolipoprotein-AIV Downregulated in Patients with Major Depressive
Disorder having Suicidal Ideation Compared to those without Suicidal
Ideation
Authors: Mandal Amit Kumar , Mathew Boby , Srinivasan Krishnamachari , Pradeep Johnson , Thomas Tinku 
Published: November 2021

Background:
Identification of a peripheral biological marker might aid in identifying patients
at high risk of attempting suicide and might help in effective early intervention.

Objective:
In the present study, we extend the findings of our previous multidimensional proteomics
study by examining the levels of plasma Apolipoprotein-AIV in patients diagnosed with
major depression with and without suicidal ideation compared to age and gender-matched controls.

Methods:
Using the mass spectrometry platform, we quantified the levels of plasma Apolipoprotein-
AIV in patients with major depressive disorder with and without suicidal ideation compared to
matched controls with isotope-labelled peptides-based quantitative proteomics approach.

Results:
The targeted quantitative proteomics approach with isotope-labelled peptides showed that
plasma Apolipoprotein-AIV was significantly downregulated in depressed patients having suicidal
ideation 1.45 (CI:1.11-1.90) compared to those without suicidal ideation 0.88 (CI:0.77-1.003).

Conclusion:
These findings extend our earlier observation of downregulation of plasma Apolipoprotein-
AIV in patients with suicidal attempts to depressed patients with suicidal ideation. The consistent
downregulation of plasma Apolipoprotein-AIV observed in both the proteomics studies
suggests Apolipoprotein-AIV might be a plasma-based biomarker for suicidal behaviour.
Omega 3 Supplementation Improves Inflammation and Antioxidant
Defense in Women with Polycystic Ovary Syndrome
Authors: Mekki Khedidja , Benharrat Latifa Imen , Senouci Azzeddine , Benhabib Wassila 
Published: November 2021

Background:
Polycystic ovary syndrome (PCOS) is the most common female
endocrine disorder and is accompanied by metabolic syndrome (MS), a risk factor for cardiovascular
disorders.

Objective:
To evaluate the effect of Omega 3 on the improvement of some metabolic parameters.

Materials/Methods:
Sixty women (29±6 years) with PCOS and MS were randomized into two
groups: 30 received supplementation with omega-3 (Doppelherz, Activ, Germany), 3g/day (1g
per capsule and 3 capsules/day), (180mg Eicosapentaenoic Acid (EPA)/ 120mg Docosahexaenoic
Acid DHA per day), and 30 were used as controls. Blood samples were drawn at baseline
(T0), 3 weeks (T1) and 6 weeks (T2) after start of treatment. We analysed glycemia, lipid
profile, markers of inflammation and oxidative stress.

Results:
In omega-3 group compared to control, a reduction (p<0.05) in glucose levels was
noted at T1 and T2. C-reactive protein (CRP) concentrations were decreased (-25%) at T2. Oxidative
stress remain unchanged, but the activity of superoxide dismutase increased as well as
the concentrations of Catalase and thiols at T1 and T2 (p<0.001).

Conclusion:
Omega 3 supplementation improves hyperglycemia, inflammation, and antioxidant
defense in PCOS women with MS, and may lead to decreased cardiovascular complications.
Withdrawal Notice: Developing a Nanoemulsion for Permeation of Peptides of Bee Venom through the Skin
Authors: Yousefpoor Yaser , Amani Amir , Divsalar Adeleh , Vafadar Mohammad Reza 
Published: November 2021

The article has been withdrawn at the request of the authors of the journal Current Nanoscience.

Bentham Science apologizes to the readers of the journal for any inconvenience this may cause.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

BENTHAM SCIENCE DISCLAIMER:
It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.
High-frequency Repetitive Transcranial Magnetic Stimulation (rTMS) Accelerates
onset Time of Beneficial Treating Effects and Improves Clinical
Symptoms of Depression
Authors: Zou Shaohong , Dai Lilei , Wang Peng , Du Hui , Guo Qingshan , Li Fen , He Xinfu 
Published: November 2021

Background:
In recent years, more and more patients with depression demonstrate suicidal
intention and suicidal behavior.

Objective:
To evaluate the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in
treating depression with suicidal ideation.

Methods:
Eighty-nine depression patients with suicide intention were administrated drugs combined
with four weeks of Active rTMS (n=40) or sham (n=49) rTMS treatment. The 24-item Hamilton
Depression Rating Scale for Depression (HAMD-24) and Self-rating Idea of Suicide Scale
(SIOSS) were used to evaluate suicide risk and depression severity at baseline, weeks 2 and 4. A
25% reduction in HAMD-24 score from baseline was defined as treatment response. More than a
20% reduction in HAMD-24 score from baseline within the first 2 weeks of treatment was defined
as an early improvement.

Results:
No statistical significance was found for baseline sociodemographic and illness characteristics
between the two groups (P >0.05). There was a significant difference for HAMD-24 and
SIOSS scores between the two groups at weeks 2 and 4. Active rTMS group demonstrated a more
significant score reduction compared to the Sham rTMS group at weeks 2 and 4. There was a significantly
greater number of patients with early improvement observed in the Active rTMS group compared
to those in the Sham rTMS group at weeks 2 (P <0.05). There was a significant difference in
responder rates between the two groups at weeks 4 for HAMD-24 scores (P <0.05).

Conclusion:
rTMS could accelerate the onset time of beneficial treating effects and improve clinical
symptoms of depression. During the treatment course, cognitive disorder, sleep disorder, anxiety/
somatization, retardation, and hopelessness symptoms were improved dramatically, and suicidal
ideation was reduced.
Pelaksanaan Moodle di Masa Pandemi Covid-19 pada Mata Pelajaran Matematika Kelas 11 IPA
Authors: Altania Ega , Sungkono Sungkono 
Published: November 2021

Penelitian ini bertujuan untuk: (1) Menganalisis pelaksanaan e-learning Moodle. (2) Menganalisis manfaat dan dampak pelaksanaan e-learning Moodle.(3) Menganalisis faktor pendukung, faktor penghambat dan solusi dalam pelaksanaan e-learning Moodle. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kualitatif. Hasil penelitian menunjukkan bahwa: (1) Perencanaan e-learning moodle meliputi perencanaan sarana dan prasarana, keadaan sumber daya manusia, RPP, Kurikulum Darurat pandemi covid 19, bahan ajar, dan materi pembelajaran. (2) Pelaksanaan e-learning Moodle meliputi kegiatan belajar mengajar yang dimulai dengan pengingat whatsapp grup, presensi, mengupload materi, mempelajari materi, mengumpulkan tugas, dan mendapatkan feedback berupa nilai dari guru. Model pembelajaran yang digunakan adalah problem based learning dengan metode penugasan, tanya jawab, dan diskusi. (3) Evaluasi yang dilakukan menggunakan evaluasi formatif dan evaluasi sumatif. (4). E-learning moodle memberikan manfaat pembelajaran menjadi lebih terorganisir serta dampaknya motivasi belajar stagnan dan keterbatasan komunikasi. (5) Faktor yang mendukung yaitu: kemandirian belajar, kesiapan belajar, kesehatan jasmani, bantuan paket data, materi pembelajaran ,dukungan keluarga, dan sarana prasarana. Faktor yang menghambat yaitu: keterbatasan jaringan dan server down, solusinya dapat mengikuti susulan dan refresh web. Kata kunci: E-Learning Moodle, Pembelajaran Matematika
Adoption of the Website and Mobile App of a Preventive Health Program Across Neighborhoods With Different Socioeconomic Conditions in the Netherlands: Longitudinal Study
Authors: Agachi Elena , Bijmolt Tammo H A , Mierau Jochen O , van Ittersum Koert 
Published: November 2021

Background
Socioeconomic disparities in the adoption of preventive health programs represent a well-known challenge, with programs delivered via the web serving as a potential solution. The preventive health program examined in this study is a large-scale, open-access web-based platform operating in the Netherlands, which aims to improve the health behaviors and wellness of its participants.

Objective
This study aims to examine the differences in the adoption of the website and mobile app of a web-based preventive health program across socioeconomic groups.

Methods
The 83,466 participants in this longitudinal, nonexperimental study were individuals who had signed up for the health program between July 2012 and September 2019. The rate of program adoption per delivery means was estimated using the Prentice, Williams, and Peterson Gap–Time model, with the measure of neighborhood socioeconomic status (NSES) used to distinguish between population segments with different socioeconomic characteristics. Registration to the health program was voluntary and free, and not within a controlled study setting, allowing the observation of the true rate of adoption.

Results
The estimation results indicate that program adoption across socioeconomic groups varies depending on the program’s delivery means. For the website, higher NSES groups have a higher likelihood of program adoption compared with the lowest NSES group (hazard ratio 1.03, 95% CI 1.01-1.05). For the mobile app, the opposite holds: higher NSES groups have a lower likelihood of program adoption compared with the lowest NSES group (hazard ratio 0.94, 95% CI 0.91-0.97).

Conclusions
Promoting preventive health programs using mobile apps can help to increase program adoption among the lowest socioeconomic segments. Given the increasing use of mobile phones among disadvantaged population groups, structuring future health interventions to include mobile apps as means of delivery can support the stride toward diminishing health disparities.
Penerapan Metode Probing Prompting Untuk Meningkatkan Aktivitas dan Hasil Belajar Matematika Mahasiswa AMIK Mitra Gama
Authors: Tambunan Novidawaty 
Published: November 2021

In attending mathematics lectures, new students are often passive due to the non-uniform background of understanding concepts and adjustment factors for the new campus environment. This research is a Classroom Action Research (CAR) that aims to determine the increase in activity and learning outcomes of Discrete Mathematics in the first semester students of the Computer Management Skills Program to apply the Probing Prompting learning method. The research was conducted on 2018/2019 odd semester students with a total of 30 students. Data were collected through observation and learning outcomes tests. The application of the probing prompting method on the subject of the Matrix can increase the learning activities of new students; it can be seen that the average value of student learning activities from cycle I to cycle II has increased significantly. Student mathematics learning outcomes on the Matrix subject also experienced a significant increase from cycle I to cycle II. It can be concluded that the use of the probing prompting learning model in mathematics learning in the Matrix subject can increase student activity and learning outcomes.
PEMODELAN GENERATOR YANG EFEKTIF YANG DIPASANGKAN DENGAN IMPACT WRENCH SEBAGAIUSAHA UNTUK MENINGKATKAN DAYA PADA PEMBANGKIT LISTRIK TENAGA SAMPAH
Authors: Ngaderman Hubertus , Sinaga Ego Srivajawaty 
Published: November 2021

The amount of waste can be overcome, some efforts are needed to reduce it. This research will focus on the numerical model of a solid waste power plant. Researchers replace turbine with an impact which have a specification certain pressure, the impact rotates the generator The purpose of this research is to get the rms voltage of a generator, where the generator is a generator capable of supplying a rms voltage. This effort is made to convert waste energy into electrical energy. Generators which are the main topic in this research are synchronous generators and permanent magnet generators. Water with a mass of requires a temperature of to provide the required stress, while water with a mass of , its temperature is Water with a mass of requires a temperature of to provide the required voltage, while water with a mass of has a temperature of . For a water mass of , a temperature of , the synchronous rotor speed is , the rms voltage is . To reach the rms voltage of , the rotor on the generator must rotate at a synchronous speed of .
IDENTIFIKASI LIMBAH PALM OIL MILL EFFLUENT (POME) MENGGUNAKAN BIOSENSOR BERBASIS ALGA
Authors: Maryani Dina , Umar Lazuardi 
Published: November 2021

Palm Oil Mill Effluent (POME) merupakan limbah minyak kelapa sawit yang memiliki kadar Chemical Oxygen Demand (COD) dan Biochemical Oxygen Demand (BOD) yang tinggi dan sehingga merusak ekosistem periairan serta menurunkan kadar oksigen terlarut (DO). Namun, POME memiliki nutrisi untuk sel alga dalam memproduksi oksigen. Berdasarkan hal tersebut diperlukan identifikasi POME yang jatuh kebadan air berdasarkan fotosintesis Chlorella sp. menggunakan biosensor. Biosensor telah banyak dikembangkan dalam aplikasi bidang lingkungan dengan melihat kadar oksigen terlarut sebagai kualitas perairan. Penelitian ini menggunakan biosensor dengan prinsip sensor amperometris tipe Biochip-G. Sensor amperometris mengukur perubahan arus dari reaksi reduksi dan oksidasi dan menghasilkan potensial keluaran yang terukur. Potensial keluaran yang terukur merupakan kadar oksigen terlarut dari penambahan POME terhadap Chlorella sp. ketika proses fotosintesis terjadi. Identifikasi POME berdasarkan proses fotosintesis Chlorella sp. menggunakan cahaya artifisial LED Putih 380 nm-780 nm dengan tingkat variasi konsentrasi POME sebanyak 10%, 20%, dan 30%. Berdasarkan pengukuran kadar oksigen terlarut (DO) menghasilkan nilai DO sebesar 174.15%, 154.66%, dan 138.98% serta nilai sensitivitas sebesar 4mV/%POME.
PENINGKATAN FITUR-FITUR MS.WORD DAN SOFTWARE MENDELEY UNTUK MEMBANTU MAHASISWA DALAM PENYUSUNAN TUGAS AKHIR
Authors: Deswardani Frastica , Nurhidayah Nurhidayah , Pebralia Jesi , Rustan Rustan , Restianingsih Tika 
Published: November 2021

Penulisan tugas akhir menjadi kewajiban setiap mahasiswa sebelum menyelesaikan masa studinya. aplikasi yang sering digunakan dalam penulisan adalah Microsoft Word. Beberapa mahasiswa masih terlalu asing dalam menggunakan fitur-fitur advanced dalam Microsoft Word. Selain itu, dalam penulisan tugas akhir membutuhkan referensi sebagai tinjauan pustaka tentang topik penelitian yang dipilih. Beberapa mahasiswa masih mengalami kesalahan dan kebingungan dalam menulis daftar pustaka dan menulis kutipan secara rapi di tulisannya. Oleh karena itu, dilakukan kegiatan pengabdian kepada masyarakat oleh tim dosen prodi fisika Universitas Jambi dengan tema â€œPeningkatan Advanced Skill pada Fitur Microsoft Word dan Software Mendeley untuk Membantu Mahasiswa dalam Penyusunan Tugas Akhirâ€. Program pengabdian ini ditujukan untuk mahasiswa di lingkungan Fakultas Sains dan Teknologi. Metode kegiatan yang dilakukan berupa workshop pemaparan materi dan diikuti dengan bimbingan intensif kepada beberapa mahasiswa. Kegiatan workshop dilakukan secara daring pada tanggal 5 September 2020 dan diikuti oleh 50 mahasiswa yang sedang atau akan melaksanakan tugas akhir. Setelah pelatihan selesai, dipilih beberapa mahasiswa dari peserta yang sedang melaksanakan Tugas Akhir untuk mengikuti pendampingan intensif. Dalam kegiatan ini mahasiswa memahami dan dapat mempraktekkan secara langsung fitur-fitur microsoft word dan software mendeley dalam tugas akhir mereka. Pelatihan ini memberikan banyak manfaat kepada mahasiswa terutama dalam penulisan daftar pustaka, penyusunan halaman, dan membuat gambar atau tabel.
Kata Kunci: tugas akhir, pelatihan, microsoft word, mendeley
Stateless Person dalam tinjauan Hukum Nasional dan Hukum Internasional di Indonesia
Authors: Khalid Fadjri , Ardianto Budi 
Published: November 2021

Penelitian ini bertujuan untuk mengetahui bagaimana pengaturan Orang Tanpa Kewarganegaraan atau Stateless Person berdasarkan instrumen hukum internasional maupun instrumen hukum nasional di Indonesia. Indonesia yang terdampak dalam globalisasi karena gencarnya promosi pariwisata memiliki pengaturan terhadap lalu lintas orang asing melalui Undang-undang Nomor 6 Tahun 2011 tentang Keimigrasiaan dan disisi lain Indonesia tidak mengakui keberadaan Orang Tanpa Kewarganegaraan berbeda dengan pengaturan sebagaiman tercantum dalam Convention Relating To The Status of Stateless Persons 1954. Penelitian ini bertujuan untuk mengetahui bahwa pengaturan mengenai Orang Tanpa Kewarganegaraan di Indonesia untuk saat ini belum diatur secara khusus. Walaupun Indonesia telah meratifikasi International Covenant on Civil and Political Rights. Hal ini menunjukkan bahwa Indonesia belum mengatur dengan tegas dan dalam penanganannya terhadap Orang Tanpa Kewarganegaraan cenderung lambat yang mengakibatkan pendetensian melebihi ambang dari batas yang ditentukan. Adapun rumusan masalah yang diangkat yakni bagaimana pengaturan Orang Tanpa Kewarganegaraan dalam Hukum Internasional dan dalam hukum keimigrasian Indonesia beserta konsukuensi hukum yang di dapat. Metode penelitian yang digunakan adalaha tipe normative dengan cara studi pustaka. Hasil penelitian ini menunjukkan bahwa pengaturan Orang Tanpa Kewarganegaraan di lingkup Internasional berbeda dengan pengaturan di Indonesia karena tidak adanya peraturan yang tegas mengenai hal ini.