bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Factors and Long-Term Outcome with ANCA-Associated Kidney Vasculitis in Childhood
Authors: Calatroni Marta , Consonni Filippo , Allinovi Marco , Bettiol Alessandra , Jawa Natasha , Fiasella Susanna , Curi Dritan , Abu Rumeileh Sarah , Tomei Leonardo , Fortunato Laura , Gelain Elena , Gianfreda Davide , Oliva Elena , Jeannin Guido , Salviani Chiara , Emmi Giacomo , Bodria Monica , Sinico Renato A. , Moroni Gabriella , Ramirez Giuseppe A. , Bozzolo Enrica , Tombetti Enrico , Monti Sara , Bracaglia Claudia , Marucci Giulia , Pastore Serena , Esposito Pasquale , Catanoso Maria G. , Crapella Barbara , Montini Giovanni , Roperto Rosa , Materassi Marco , Rossi Giovanni M. , Badalamenti Salvatore , Yeung Rae S.M. , Romagnani Paola , Ghiggeri Gian M. , Noone Damien , Vaglio Augusto 
Published: May 2021

Background and objectives
ANCA-associated vasculitis is extremely rare in children. We report the clinicopathologic features, long-term outcomes, and prognostic factors of a large pediatric cohort of patients with ANCA-associated kidney vasculitis.

Design, setting, participants, & measurements
This retrospective study included 85 consecutive patients with kidney biopsy specimen–proven ANCA-associated vasculitis from tertiary referral centers in Italy and Canada. Kidney biopsy specimens were categorized as focal, crescentic, sclerotic, or mixed, according to the Berden classification. The prognostic significance of baseline clinical, laboratory, and histologic findings was analyzed with respect to kidney failure or CKD stage 3–5/kidney failure.

Results
A total of 53 patients had microscopic polyangiitis (62%), and 32 had granulomatosis with polyangiitis (38%). Rapidly progressive GN was the most frequent presentation (39%); a third of the patients also had nephrotic-range proteinuria. Kidney biopsy specimens were classified as focal in 21% of the patients, crescentic in 51%, sclerotic in 15%, and mixed in 13%. Remission-induction therapies included cyclophosphamide in 78% of patients. A total of 25 patients (29%) reached kidney failure. The median (interquartile range) time to kidney failure or last follow-up was 35 (6–89) months in the whole cohort, and 73 (24–109) months among the patients who did not reach this outcome. Patients whose biopsy specimens showed sclerotic histology had significantly shorter kidney survival (hazard ratio, 11.80; 95% confidence interval, 2.49 to 55.99) and survival free of CKD stage 3–5 (hazard ratio, 8.88; 95% confidence interval, 2.43 to 32.48), as compared with those with focal/mixed histology. Baseline eGFR, low serum albumin, hypertension, central nervous system complications, and sclerotic histology, which reflected severe kidney involvement, were associated with both kidney failure and CKD stage 3–5/kidney failure at unadjusted analysis; no independent prognostic factors emerged at multivariable analysis.

Conclusions
Children with ANCA-associated kidney vasculitis often have aggressive presentation; a third of such children progress to kidney failure and this usually occurs early during follow-up. A severe clinical presentation is associated with the development of CKD or kidney failure.
EFEITO DA LACUNA PREENCHIDA E PLAUSIBILIDADE SEMÂNTICA NO PROCESSAMENTO DE FRASES EM PORTUGUÊS BRASILEIRO
Authors: Maia Marcus 
Published: May 2021

Investiga-se o efeito da lacuna preenchida (ELP) em português brasileiro através de experimentos de rastreamento ocular e de leitura automonitorada. Os resultados detectam a presença do ELP e indicam que o parser atua de modo estritamente sintático em sua fase inicial. As medidas das fases finais integrativas dos dois experimentos são divergentes e motivam uma discussão sobre efeitos do tipo good-enough.
Finding Information Framework: A Tool to Teach Life-Long Learning Skills
Authors: Cohen-Osher Molly , Davies Theresa A. , Flynn David B. , Young Megan E. , Hoffman Miriam 
Published: May 2021

Introduction: In this age of rapid information expansion, medical education can no longer be taught solely by information acquisition, but rather requires information management and information mastery at both the point of learning as well as at the clinical point of care. We must teach our trainees how to ask, categorize, and answer their own questions—skills required to be a life-long learner. We developed the Finding Information Framework (FIF), a conceptual algorithm as well as web-based tool and app, to guide medical students in asking and categorizing their questions and to link them directly to the most appropriate information resource for their questions. Here we assess the functionality of the FIF following its implementation in the first-year medical school curriculum problem-based learning (PBL) course.
Methods: First-year medical students (n=126) utilized the FIF in their longitudinal problem-based learning course discussion groups and completed an anonymous survey.
Results: Qualitative and quantative data suggest that the FIF was easy to use (86.5%), supported the course curriculum (80%), and helped students find relevant information to answer their questions (77%) from trusted reliable resources (70%). Qualitative comments also suggest that the FIF is initially a helpful tool during the PBL course but becomes less useful over time as students become more familiar with resources.
Conclusion: The FIF assists students in identifying trusted resources and in efficiently and effectively finding answers to questions at the point of learning. These data suggest that students are internalizing the tool’s conceptual algorithm over time, reinforcing the teaching of information management and information mastery.
Meta-Analysis of Seven Standard Experimental Paradigms Comparing Student to Non-student
Authors: Zumaeta Jorge N. 
Published: May 2021

This study embarked on the very challenging proposition of systematically organizing and classifying an assortment of experimental economics essays pertinent to seven experiments performed with both non-student and student populations. The experiments were the Dictator game, Stag Hunt – Coordination game, Risk Aversion Measurement (as measured by the players type of lottery choice), Trust game, Guessing game, Prudence Measurement, and the Guessing game. This meta-analysis reviewed 126 published and unpublished papers collected from several journals and papers provided by several authors via the Google Groups "Economic Science Association - Experimental Methods Discussion" group. Ultimately, only 39 studies were utilized due to methodological alignment. While some studies showed statistically significant differences between non-students and students as indicated by their respective 95% confidence intervals, the overall random-effects model of each of the seven games showed not to be statistically significant. This study contributes to the literature in three important ways. First, the study generates a comprehensive inventory and review of experiments comparing student to non-student populations for the last four decades; second, the study points out a possible limitation when combining several studies of the same game, despite following similar protocols, suggesting that compounded contextual complexities might diminish aggregate effects of the individuals’ behavioral responses to the financial incentives, and third, the study indicates that generalizations from one experimental economic study, may not render a solid base for extending statistical extrapolations applicable to the total population since the aggregate effects do not indicate substantial differences.
The Theme of Love in Paulo Coelho’s Select Novels
Authors: Punitha J. , UmaSamundeeswari Dr.J. 
Published: May 2021

Coelho’s popular `The Alchemist` is not a novel on the roles of men and women and it is not making any statement about mundane love except talking about a mystical Universal love. But it does say about love being one of the most important and valuable treasures that can be found. The other novels are equally mystical leaning much on Erosand Agape. Rather they try to show the inner lanes of agape. This is a brief attempt to show the author’s experience of agape is not only universal but also personal.
INTOXICAÇÃO POR MEDICAMENTOS EM TRÊS MICRORREGIÕES DO INTERIOR DE SÃO PAULO: PERFIL EPIDEMIOLÓGICO
Authors: FACHINCONI Gleice Karen Nogueira , RIBEIRO Veridiane Alves , AQUINO Rafael Guerra 
Published: May 2021

A intoxicação por medicamentos é o tipo de intoxicação exógena de maior incidência no Brasil. Este estudo tem como objetivo descrever e analisar o perfil epidemiológico das vítimas de intoxicação por medicamentos das microrregiões de Santa Fé do Sul, Jales e Fernandópolis no período de 2015 a 2019. É um estudo retrospectivo, descritivo e exploratório, com abordagem quantitativa. Os dados secundários foram fornecidos pelo Grupo de Vigilância Epidemiológica XXX. Durante o período, foram registrados 1855 casos, com uma média de 371 casos ao ano. O ano com maior ocorrência foi 2019, com 451 casos registrados. Houve uma maior incidência no sexo feminino (76,3%). Em relação à raça, destacou-se a branca (78%). A faixa etária com maior ocorrência foi de 20 a 29 anos, nos primeiros anos, porém, em 2019, houve um aumento de casos na faixa de 10 a 19 anos. Conclui-se que houve um aumento de 17,7% dos casos em 2019, com prevalência entre mulheres e adolescentes. Há necessidade de incentivo da notificação e prevenção dessas intoxicações, visto que sugerem que a maior causa sejam as tentativas de suicídio, sendo este um problema de saúde pública.

MEDICATION POISONING IN THREE MICRO-REGIONS OF SÃO PAULO COUNTRYSIDE: EPIDEMIOLOGIC PROFILE

ABSTRACT
Medication poisoning is the kind of exogenous poisoning with the highest incidence in Brazil. This paper aims at describing, and analyzing the epidemiologic profile of medication poisoning victims in the micro-regions of Santa Fé do Sul, Jales, and Fernandópolis in the period from 2015 to 2019. It is a retrospective, descriptive and exploratory study, quantitative approach. Secondary data was provided by Grupo de Vigilância Epidemiológica XXX. During that period 1855 cases were reported with an average of 371 cases per year. The year with the highest occurrence was 2019 when 451 cases were reported. The highest incidence was in females (76,3%). Regarding race, the Caucasian race stood out (78%). The age group with the highest incidence was the 20-29 years old, in the early years, although, in 2019, there was an increase of cases in the 10-19 age group. We conclude that there was an increase of 17,7% in cases in 2019, with the prevalence of women and teenagers. It is necessary to encourage the notification and prevention of poisoning, since they suggest that the main cause of them were due to suicide attempts, which makes it a public health problem.

Descriptors: Emergency; Nursing and emergency. Poisoning. Epidemiology. Surveillance.
Reply to a letter from Robert Colebunders entitled COVID-19: The African Enigma
Authors: Guerrero Rodrigo , Bravo Luis Eduardo , Muñoz Edgar , Grillo Ardila Elvia Karina , Guerrero Esteban 
Published: May 2021

We thank Dr. Colebunders for his comments regarding our manuscript. Our study was an ecological study prompted by the low frequency of cases and deaths from the SARS-CoV-2 COVID-19 virus in some African countries. We agree with Dr. Colebunders that other factors could explain the observed association between APOC countries and COVID-19 mortality. However, these unmeasured confounders would have to be strongly associated with Covid-19 mortality to explain the observed 28% reduction. In updated information, as of 12-17-20, APOC countries had a 42% lower risk of death than the non-APOC countries, adjusted for confounders. (Not published)
Hellwig et al., in addition to reporting similar findings to ours for African and Asian countries, surmised that they may be connected to ivermectin’s ability to inhibit SARS-CoV-2 replication suggesting other pathways must exist to explain the persistence of such an inhibitory effect after serum levels of ivermectin have declined. As mentioned by Mbow et al. “, it is increasingly recognized that the immune system is shaped not only by genetics but also by environmental factors, such as exposure to microorganisms and parasites. This educates the immune system to protect against invading pathogens not only specifically but also nonspecifically through, for example, “trained immunity,” which involves the reprogramming of innate cells that, on secondary encounter with a pathogen, can show a stronger response.” Those infections, such as onchocerciasis, may downregulate immune responses and potentially inactivate the inflammatory signalling pathways that may induce acute respiratory distress syndrome (ARDS), one of the causes of death in COVID-19 infected persons, seems very attractive explanation.
Assessing the Role of the Green Finance Index in Environmental Pollution Reduction
Authors: Iqbal Sajid , Taghizadeh-Hesary Farhad , Mohsin Muhammad , Iqbal Wasim 
Published: May 2021

A substantial amount of green finance is required for the transition to green energy, in order to control global warming. We used a common weight DEA composite indicator to develop a green finance index to measure the combined effects of energy, environment, and financial variables. The resulting green finance index values range from 0.98 to 0.71. According to results, Iceland and Nepal both have a score of 1.00, while Australia is third with 0.98 and Malta the lowest value of 0.71. The UK has a score of 0.23 and India has a score of 0.15. The findings of this study offer an understanding of the role of green finance in environmental pollution reduction. We suggest several policy implications or solutions for governments, institutions, industries and the public to work towards environmental pollution reduction.A substantial amount of green finance is required for the transition to green energy, in order to control global warming. We used a common weight DEA composite indicator to develop a green finance index to measure the combined effects of energy, environment, and financial variables. The resulting green finance index values range from 0.98 to 0.71. According to results, Iceland and Nepal both have a score of 1.00, while Australia is third with 0.98 and Malta the lowest value of 0.71. The UK has a score of 0.23 and India has a score of 0.15. The findings of this study offer an understanding of the role of green finance in environmental pollution reduction. We suggest several policy implications or solutions for governments, institutions, industries and the public to work towards environmental pollution reduction.
Determination of Kinetic Properties in Unimolecular Dissociation of Complex Systems from Graph-Theory Based Analysis of an Ensemble of Reactive Trajectories.
Authors: Perez-Mellor Ariel F. , Spezia Riccardo 
Published: May 2021

We describe and apply a general approach based on graph-theory to obtain kinetic and structural properties from direct dynamics simulations. In particular, we focus on the unimolecular fragmentation of complex systems in which, prior to dissociation, different events can take place, and notably isomerizations and formation of ion-molecule complex.3-state and 4-state kinetic models are thus obtained and rate constants for global or specific pathways are obtained from direct counting and flux calculation, both being in agreement.Finally, we show how a theoretical mass spectrum can also be obtained automatically.
Clinical characteristics and risk factors associated with severe COVID-19: prospective analysis of 1,045 hospitalised cases in North-Eastern France, March 2020
Authors: Kaeuffer Charlotte , Le Hyaric Coralie , Fabacher Thibaut , Mootien Joy , Dervieux Benjamin , Ruch Yvon , Hugerot Antonin , Zhu Yves-Jean , Pointurier Valentin , Clere-Jehl Raphael , Greigert Valentin , Kassegne Loic , Lefebvre Nicolas , Gallais Floriane ,   Covid Alsace Study Group, Meyer Nicolas , Hansmann Yves , Hinschberger Olivier , Danion François 
Published: May 2021

Background
In March 2020, the COVID-19 outbreak was declared a pandemic by the World Health Organization.

Aim
Our objective was to identify risk factors predictive of severe disease and death in France.

Methods
In this prospective cohort study, we included patients ≥ 18 years old with confirmed COVID-19, hospitalised in Strasbourg and Mulhouse hospitals (France), in March 2020. We respectively compared patients who developed severe disease (admission to an intensive care unit (ICU) or death) and patients who died, to those who did not, by day 7 after hospitalisation.

Results
Among 1,045 patients, 424 (41%) had severe disease, including 335 (32%) who were admitted to ICU, and 115 (11%) who died. Mean age was 66 years (range: 20–100), and 612 (59%) were men. Almost 75% of patients with body mass index (BMI) data (n = 897) had a BMI ≥ 25 kg/m2 (n = 661). Independent risk factors associated with severe disease were advanced age (odds ratio (OR): 1.1 per 10-year increase; 95% CrI (credible interval): 1.0–1.2), male sex (OR: 2.1; 95% CrI: 1.5–2.8), BMI of 25–29.9 kg/m2 (OR: 1.8; 95% CrI: 1.2–2.7) or ≥ 30 (OR: 2.2; 95% CrI: 1.5–3.3), dyspnoea (OR: 2.5; 95% CrI: 1.8–3.4) and inflammatory parameters (elevated C-reactive protein and neutrophil count, low lymphocyte count). Risk factors associated with death were advanced age (OR: 2.7 per 10-year increase; 95% CrI: 2.1–3.4), male sex (OR: 1.7; 95% CrI: 1.1–2.7), immunosuppression (OR: 3.8; 95% CrI: 1.6–7.7), diabetes (OR: 1.7; 95% CrI: 1.0–2.7), chronic kidney disease (OR: 2.3; 95% CrI: 1.3–3.9), dyspnoea (OR: 2.1; 95% CrI: 1.2–3.4) and inflammatory parameters.

Conclusions
Overweightedness, obesity, advanced age, male sex, comorbidities, dyspnoea and inflammation are risk factors for severe COVID-19 or death in hospitalised patients. Identifying these features among patients in routine clinical practice might improve COVID-19 management.
Developing Psychological Empowerment and Patient Safety Culture: A Pre-experimental Study
Authors: YILMAZ Ayşegül , DUYGULU Sergül 
Published: May 2021

Aims: This study aimed to examine the development of the perceptions of the psychological empowerment and patient safety culture among Turkish nurses by implementing a training-based empowerment program for unit charge nurses.
Methods: A pre-experimental, one-group pretest-posttest test design was used. The sample consisted of (n = 38) unit charge nurses and (n = 174) staff nurses; the program included theoretical components, group work, and individual study assignments. Data was collected using the Demographic Data Sheet, Psychological Empowerment Scale and Hospital Survey on Patient Safety Culture before, immediately after, and four months after the program. Data were analysed by percentages, repeated measures analysis of variance, and the Friedman analysis was used for the abnormally distributed data. The Cochran's Q test was used to analyze the number of events reported.
Results: There was a statistically significant increase found in the results of the Psychological Empowerment Scale's scores on the competence and meaning subscales, the mean positive response to teamwork within the unit’s composite of Hospital Survey on Patient Safety Culture (p < 0.05), and event reporting (p < 0.001).
Conclusion: The results of this study suggest that creating a positive patient safety culture requires a review of the structures and processes of an organization. Creating, maintaining a desirable patient safety culture in health institutions is a long and hard process. The duration of future empowerment programs may be determined to allow for the long-term monitoring of their effects.
Pengantar Redaksi
Authors: Mujiburohman Dian Aries 
Published: May 2021

Puji syukur kepada Tuhan Yang Maha Esa, karena edisi ketiga Jurnal Tunas Agraria (JTA) ini, dapat kembali terbit ke hadapan para pembaca dengan segala kelebihan dan kekurangannya. Edisi ini mengangkat tema sekitar Tata Ruang, Pengadaan Tanah, Pendaftaran Tanah, dan Pengukuran.
Inkonsistensi Kebijakan antara Penghentian Pemberian Izin Baru (PPIB) dengan Percepatan Pendaftaran Tanah Sistematis Lengkap (PTSL) di Kabupaten Siak Provinsi Riau
Authors: Dwi Saputra Maryono 
Published: May 2021

Salah satu masalah dalam pelaksanaan Pendaftaran Tanah Sistematis Lengkap (PTSL) di Kabupaten Siak adalah adanya Peta Indikatif Penghentian Pemberian Izin Baru (PIPPIB) yang menyebabkan Kantor Pertanahan yang terkena dampak dari kebijakan tersebut. Tujuan dari penelitian ini adalah untuk mengetahui pelaksanaan PTSL di dalam PIPPIB, terjadinya inkonsistensi kebijakan, serta memberikan rekomendasi kebijakan PTSL yang berada di alamPIPPIB. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif dengan pendekatan yuridis normatif dan spasial. Hasil penelitian diketahui sebanyak 634 bidang tanah PTSL tahun 2020 masuk di dalam PIPPIB. Inkonsistensi antara kebijakan penghentian pemberian izin baru dengan kebijakan PTSL terjadi karena kurang hati-hati dan koordinasi antar pihak terkait dalam perumusan kebijakan. Rekomendasi kebijakan PTSL dengan memperhatikan peraturan yang lebih tinggi, peraturan terkait dan koordinasi dengan pihak terkait menjadi mekanisme dalam perumusan kebijakan PTSL.
WRITTEN CORRECTIVE FEEDBACK IN ACADEMIC WRITING CLASS: HOW DOES EXPERIENCED TEACHER LEAD THE EFFECTIVE PRACTICE?
Authors: Dayat Dayat 
Published: May 2021

<p class="StyleAuthorBold"><strong>Abstract</strong></p><p>The research aimed to investigate an Indonesian academic writing teacher’s practice on written corrective feedback (WCF) in academic writing class. A case study involving an experienced Indonesian academic writing teacher and teacher students were employed. To gather data, a semi-structured interview was conducted. The data were then analyzed using the content analysis method. The findings indicated that the teacher’s practice on WCF was mediated by her language learning experience. Thus, the teacher provided WCF on her students’ writing drafts by considering the students’ personalities and their level of writing ability. In correcting student writing errors, the teacher used several types of WCF; direct and indirect correction; metalinguistic clues to the errors; and the reformulation of the wrong words. The relevant pedagogical implications for teachers in conceptualizing WCF and in learning and practicing it on their daily instruction based on their knowledge, experience, and reflection-on-practice.</p><p> </p><p class="StyleAuthorBold"><strong><em>Abstrak</em></strong></p><p><em>Penelitian bertujuan untuk mendeskripsikan praktik dosen Indonesia dalam penulisan akademik tentang umpan balik korektif tertulis (WCF) di kelas penulisan akademik. Penelitian termasuk studi kasus yang melibatkan seorang dosen Indonesia dalam menulis akademik yang berpengalaman dan mahasiswa. Untuk mengumpulkan data, dilakukan wawancara semi-terstruktur. Data tersebut kemudian dianalisis dengan menggunakan metode analisis isi. Temuan menunjukkan bahwa praktik dosen pada WCF dimediasi oleh pengalaman belajar bahasanya. Dosen memberikan WCF pada draf tulisan mahasiswanya dengan mempertimbangkan kepribadian mahasiswa dan tingkat kemampuan menulisnya. Dalam mengoreksi kesalahan menulis mahasiswa, dosen menggunakan beberapa jenis WCF; koreksi langsung dan tidak langsung; petunjuk kesalahan metalinguistik; dan perumusan ulang kata yang salah. Implikasi pedagogis yang relevan bagi dosen dalam membuat konsep WCF dan dalam mempelajari serta mempraktikkannya pada instruksi harian berdasarkan pada pengetahuan, pengalaman, dan refleksi pada praktik yang dilaksanakan.</em></p>