bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between the number of prosthetic crowns and periodontitis: a cross-sectional study
Authors: Kim Yun-Jeong , Lee Jae-Young , Ku Young , Cho Hyun-Jae 
Published: February 2021

Abstract
BackgroundAlthough the presence of prosthetic restorations has been associated with plaque accumulation, gingivitis, and periodontitis, there is a lack of large epidemiological investigations providing credible evidence on the association of prosthetic crowns with periodontitis. The purpose of the study was to analyze the association between the number of prosthetic crowns and the presence of periodontitis.MethodsThis study was based on the Seventh Korea National Health and Nutrition Examination Survey (2016-2018). A total of 12,689 participants over the age of 19 years were surveyed. Multivariate logistic regression analyses were used to identify the association between the number of prosthetic crowns and periodontitis after adjusting for potential confounders, including demographic variables, socio-economic characteristics, oral health-related variables, and oral and systemic clinical variables. ResultsThe odds ratio of periodontitis showed statistically significant differences in the anterior and posterior regions, and the prevalence of periodontal disease increased as the number of crown prostheses increased. Participants with 6–10 and 11 prosthetic crowns had 1.24 and 1.28 times higher prevalence of periodontitis, respectively, than patients with no prosthetic crown.ConclusionsThe results of this study show that the number of prosthetic crowns present in adults is related to the prevalence of periodontitis.
Recoverable acrylamide-vinylamine copolymer immobilized TEMPO mediated oxidation of cellulose with good catalytic performance and low cellulose degradation
Authors: Sun Tingting , Wang Huimin , Liu Jiaye , Chu Xiaomeng , Xing Xuteng , Liu Shaojie , Tang Erjun , Liu Xinying , Hildebrandt Diane 
Published: February 2021

Abstract
In this work, a recoverable acrylamide-vinylamine copolymer immobilized TEMPO (P(AM-co-VAm)-T) catalyst for selective oxidation of cellulose with good catalytic performance and low cellulose degradation was developed. Firstly, the acrylamide-vinylamine copolymer (P(AM-co-VAm)) was prepared by Hofmann degradation of polyacrylamide (PAM). Then, the condensation reduction reaction between amine groups of P(AM-co-VAm) and carbonyl groups of 4-oxo-TEMPO yielded P(AM-co-VAm)-T. P(AM-co-VAm)-T was used as a catalyst for selective oxidation of C6 primary hydroxyl groups of cellulose to carboxyl groups. The carboxyl content of obtained oxidized cellulose was up to 1.114 mmol/g, which was equivalent to 76% of the free TEMPO level. This macromolecular catalyst was easily recycled and the recycling performance was excellent. Interestingly, it was found that P(AM-co-VAm)-T could effectively reduce the degradation of oxidized cellulose. The corresponding degradation degree was 21%-27%, which was much lower than the degradation degree of free TEMPO (61%-66%) and other macromolecular TEMPO catalysts, such as polyacrylic acid immobilized-TEMPO (41%-53%) and polyamidoamine supported TEMPO (28%-44%). P(AM-co-VAm)-T with positive charge and suitable size could effectively inhibit the formation of C6 aldehydes and C2/C3 ketones, which was the main reason that it could significantly inhibit cellulose degradation.
Sub-Clinical Mastitis and Reproduction: Season, Parity and Stage of Lactation Effects on Conception Rate and Milk Somatic Cell Count
Authors: Mirzaei Abdolah , Ararooti Tahereh , Ghavami Mohsen , Tamadon Amin 
Published: February 2021

Abstract
The aim of the present study was to investigate the effect of subclinical mastitis (somatic cell count (SCC)>250000 cells/ml) on the fertility of Holstein dairy cows in different parities, lactation stages and seasons. Data of 2437 SCC in a dairy farm including number of insemination, pregnancy detection, date of calving and insemination, SCC after insemination (maximum of 30 days), and parity were evaluated. The rate of subclinical mastitis in the first, second, third and fourth and more lactation number was 18.8%, 25.7%, 26.5% and 35.4%, respectively and in spring, summer, autumn and winter was 24.5%, 19.7%, 18.5% and 33.6%, respectively. Conception rate of cows with subclinical mastitis (24.6%) was lower than cows without subclinical mastitis (30.9%; P=0.003). In addition, the conception rate in the second and third lactation in cows with subclinical mastitis was significantly lower than in cows without subclinical mastitis. The conception rate of cows with subclinical mastitis in summer in the second lactation and in winter in the second and third lactation was significantly lower than in cows without subclinical mastitis. Therefore, subclinical mastitis in mid lactation stage and also in the second and third parities especially in summer and winter can disturb fertility more than the other conditions. Also, considering these facts during these periods of times in managing of subclinical mastitis can improve fertility outcome of the herd.
Computational Study on Novel Natural Inhibitors Targeting BCL2
Authors: Lv Xiaye , Jiang Yuting , Wang Xinhui , Dou Gaojing , Wang Jing , Yang Wenzhuo , Xie HaoQun , Wang Hongyu , Li Zijian 
Published: February 2021

Abstract
Object: Ideal lead compounds and candidate drugs with inhibitory effect on BCL2 were screened from ZINC database, which laid a foundation for drug development and compound improvement of drug treatment for diffuse large B-cell lymphoma (DLCBL). Methods: Identification of potential BCL2 inhibitors by computer-aided virtual screening. Libdock was applied to value 17931 compounds and top20 were selected for further analysis. Selected compounds were performed absorption, distribution, metabolism, and excretion (ADME) and toxicity prediction. The binding affinity between the selected ligands and BCL2 was confirmed by Molecular docking. Results: The new natural compounds ZINC00000255131 and ZINC00013298233 were found to bind closely with BCL2. Furthermore, they all scored lower in ames-induced mutagenicity, rodent carcinogenicity, non-developmental toxicity potential, and cytochrome P4502D6 tolerance. Molecular dynamics simulation shows that the combinations of ZINC00000255131 and ZINC00013298233 with BCL2 in the natural environment are more stable. Conclusion: Two new compounds ZINC00000255131 and ZINC00013298233 were found to be potential inhibitors of BCL2. These compounds have been proved to be safe, which is of great significance for the development and improvement of DLCBL drugs.
Eating Disorders and Non-suicidal Self-injury: Cluster Analysis Considering Eating Pathology, Emotion Dysregulation, and Negative Urgency
Authors: Gonçalves Sónia Ferreira , Ramalho Sofia , Machado Bárbara , Vieira Ana Isabel 
Published: February 2021

Abstract
Purpose:Research on the interplay between eating pathology, difficulties in emotion regulation and negative urgency is needed to better inform and tailor the current intervention approaches for patients with eating disorders and non-suicidal self-injury. The current study aimed to investigate the phenotypic characterization of patients with eating disorders and history of lifetime non-suicidal self-injury when considering eating pathology, emotion dysregulation and negative urgency. Methods: This is a cross-sectional study evaluating 73 patients with eating disorders and history of lifetime non-suicidal self-injury (14-55 years; 68 Female). A cluster analysis (K-means) was performed using eating pathology, difficulties in emotion regulation and negative urgency. Differences between clusters were explored on sociodemographic/psychological variables, distribution of the DSM-5 eating disorder diagnostics and past/current non-suicidal self-injury engagement Results: Three clusters were identified. Cluster 1 (n = 29) (moderate severity) was characterized by high levels of eating pathology, but moderate emotion dysregulation and negative urgency. Cluster 2 (n = 29) (high severity) was characterized by the highest scores in eating pathology, emotion dysregulation and negative urgency. Within this cluster there was the highest prevalence of patients with current non-suicidal self-injury. Cluster 3 (n = 15) (low severity) was characterized by the lowest levels of eating pathology, emotion dysregulation and negative urgency and included more patients with past non-suicidal self-injury. Conclusion: The three distinctive profiles highlights the importance of emotion dysregulation and negative urgency as a personalized treatment target for eating disorders patients with current NSSI. Level III: Evidence obtained from well-designed cohort or case-control analytic studies
Supramalleolar Fornix Osteotomy Combined Fibular Segamental Resection for Varus Ankle Osteoarthritis
Authors: Weng Nengyuan , Li Kainan , Hu Zhengxia , Liu Xuan , Zhang Tao , Lan Hai 
Published: February 2021

Abstract
Background: To investigate the safety and clinical effect of supramalleolar fornix osteotomy combined with fibular segmental resection in the treatment of varus ankle osteoarthritis (VAO). Methods: from July 2014 to July 2020, 38 patients with Takakura stage II - III VAO in Affiliated Hospital of Chengdu University were retrospectively analyzed, including 31 males and 7 females, 21 left ankles and 17 right ankles. They were divided into open osteotomy group (21 cases) and fornix osteotomy group (17 cases). According to the American Society of foot and ankle surgery ankle and hindfoot score (AOFAS) and visual analogue scale (VAS) for pain function and pain score; weight-bearing ankle acupoints and lateral X-ray imaging evaluation. Results: 38 patients were followed up for 16-54 months (mean 41 months). The healing time of the supramalleolar osteotomy group (3.33 ± 0.90 months) was significantly shorter than that of the open osteotomy group (6.09 ± 1.74 months) (t = -5.932, P = 0.000). The postoperative FAS score of fornix osteotomy group (85.65 ± 6.49) was significantly better than that of open osteotomy group (63.05 ± 6.42), and the postoperative VAS score of fornix osteotomy group (2.12 ± 1.05) was significantly better than that of open osteotomy group (4.38 ± 1.60) (P < 0.05). The improvement of anterior angle of distal tibia, talus inclination angle and talus lateral displacement in the fornix osteotomy group was significantly better than that in the open osteotomy group (P < 0.05); the postoperative lateral angle of distal tibia in the fornix osteotomy group was 82.05 ± 1.74 ° on average, and that in the open osteotomy group was 80.17 ± 1.34 ° on average, with no significant difference between the two groups (P > 0.05). Conclusion: The treatment of VAO with supramalleolar fornix osteotomy combined fibular segamental resection can effectively solve the anterior and talus lesions. The deformity correction around CORA can avoid the lateral displacement of the talus and effectively reduce the incidence of postoperative ankle degeneration. Short term follow up convinced better function restoration compared with open supramalleolar osteotomy.
Synthesis, Crystal Structures, Hirshfeld Surfaces Analysis and Physico-Chemical Characterization of Two New ZnII and CdII Halidometallates
Authors: rayes ali , moncer Manel , Ara Irene , Necmi Dege , Ayed Brahim 
Published: February 2021

Abstract
Two new organic-inorganic hybrid materials, based on 1,3-CycloHexaneBis-(Methyl Amine), abbreviated CHBMA, namely(H2CHBMA)ZnCl4.2H2O (CP1) and (H2CHBMA)CdI4.2H2O (CP2), have been synthesized under mild conditions in acidic media and characterized by single-crystal X-ray diffraction, spectroscopic techniques (13C NMR, FT-IR, RAMAN) and thermal analysis. The crystal structures of the two compounds were solved by single-crystal X-ray diffraction methods. Both compounds show a 3-dimensional supramolecular structure directed by various interactions between tetrahalidometallate anions (ZnCl42-, CdI42-), water molecule and organic cations (H2CHBMA)2+. For both compounds, the cyclohexane ring of the template cation is in a chair conformation with the methyl-ammonium substituent in the equatorial positions and the two terminal ammonium groups in a cis conformation but with two different orientations (upward for CP1 and downward for CP2) which influences the supramolecular architecture of the two structures. Hirshfeld surface analysis and the associated two-dimensional finger print plots were used to explore and quantify the intermolecular interactions in the crystals.
Biomimetic hygroscopic nanofibrous membrane with gradient honeycomb-like network structure for efficient atmospheric water harvesting
Authors: Zhang Yufei , Wu Lei , Zhao Xinglei , Wang Xianfeng , Yu Jianyong , Ding Bin 
Published: February 2021

Abstract
Honeycomb-like nanofibrous membranes (NFMs) are promising nanomaterials that can be used in tissue engineering, drug delivery, and water harvesting; however, enhancing the mechanical properties of these nanomaterials has proven extremely challenging. Herein, we report a biomimetic, super-flexible, highly elastic, and tough NFM-based water/fog harvester with a highly-ordered gradient honeycomb-like network structure self-assembled from electrospun spider-silk-like humped nanofibers. The resultant NFM exhibits super flexibility, strengthening (2.9 MPa), high elasticity, and toughening (3.39 MJ m− 3), allowing it to be used as the framework of hygroscopic materials. The resulting hygroscopic NFM displays excellent moisture absorption performance. It can be used as a water/fog harvester with superhigh equilibrium moisture absorption capacity of 4.60 g g− 1 at 95% RH, fast moisture absorption and transport rates, and long-term durability, achieving directional transport and collection of tiny water droplets. This work paves the way for the design and development of multifunctional NFMs with gradient honeycomb-like network structure.
The circular economy concept in the municipal wastewater and sewage sludge management – site-specific cases from Poland
Authors: Kacprzak Małgorzata Jadwiga 
Published: February 2021

Abstract
Introduction of the circular economy package as a result of the necessity to protect natural resources has also forced a new approach for effective wastewater and biowaste treatment and management. Wastewater treatment plants (WWTPs) have become crucial elements of regional bioeconomy - mainly through energy (waste to energy) and matter (nutrients-energy-water) recovery as an element of sustainable development of a smart city. In Poland in 2019 operated 3278 municipal wastewater treatment plants. To achieve specific effluent goals for BOD, nitrogen and phosphorus, different adaptations and modifications have been made. Modernization of technological lines of wastewater treatment has led to a significant improvement in the quality of treated sewage, at the largest WWTPs in Warsaw, Cracow or Gdansk. Eleven WWTPs produce approx. 34% of the total volume of approx. 337 GWh of electricity from biogas in Poland. The potential of producing electricity from biogas in WWTPs in Poland can be estimated at approx. 700–850 GWh per year. According to the data of the Statistics Poland in 2019 in Poland approx. 25% of sewage sludge was used directly in agriculture and for land reclamation. Simultaneously more than 100 WWTPs produce compost at high quality. However only few produce organic/organic-mineral fertilizers, mainly with addition of calcium.
Working Conditions in Primary Care: A Qualitative Interview Study with Physicians in Sweden Informed by the Effort-Reward-Imbalance Model
Authors: Nilsen Per , Fernemark Hanna , Seing Ida , Schildmeijer Kristina , Ericsson Carin , Skagerström Janna 
Published: February 2021

Abstract
Background: Many problems with primary care physicians’ psychosocial working conditions have been documented. Many studies on working condition have used the Effort-Reward-Imbalance (ERI) model, which posits that poor health and well-being may result from imbalances between the level of effort employees perceive that they put into their work and the rewards they receive. The model has not been used in qualitative research or applied to investigate primary care physicians’ working conditions. The aim of this study was to apply the ERI model to explore the perceived efforts and rewards by primary care physicians in Sweden and approaches they take to cope with potential imbalances between these efforts and rewards.Methods: The study has a qualitative design, using semi-structured interviews. A purposeful sampling strategy was used to achieve a heterogeneous sample of primary care physicians who represented a broad spectrum of experiences and perceptions. We recruited 21 physicians; 15 were employed in public health care and 6 by private health care companies.Results: The analysis of the interviews yielded 11 sub-categories: 6 were mapped to the efforts category, 3 were attributed to the rewards category and 2 were approaches to coping with effort/reward imbalances. Many of the statements concerned efforts in the form of high workload, restricted autonomy and administrative work burden. They also perceived resource restrictions, unpredictability of work and high expectations in their role as physicians as efforts. Three reward factors emerged; the physicians found their job to be stimulating and meaningful, and the work climate to be supportive. The physicians coped with imbalances by means of job enrichment and using decisional latitude.Conclusions: This study of primary care physicians suggests a lack of reciprocity in terms of high costs and low gains, providing a plausible explanation for work stress and associated consequences that have been shown in previous primary care research. We found the ERI model to be useful to explore physicians’ primary care work and working conditions and to identify effort and reward factors as well as approaches to managing effort/reward imbalances of relevance for their job satisfaction.
The Death Risk Factors of Patients Undergoing Re-Exploration For Bleeding or Tamponade After Isolate Off-Pump Coronary Artery Bypass Grafting: A Case-Control Study
Authors: Luan Tongxiao , Zhuang Yingzhu , Nie Weihong , Yang Sumin , Wu Yuhui , Wang Rongmei , Dai Yunyan , Zhang Hong 
Published: February 2021

Abstract
Background: The purpose of this study is to analysis the death risk factors of re-exploration for bleeding or tamponade after isolate off-pump coronary artery bypass grafting (OPCABG).Methods: We analyzed the data of 3256 consecutive patients undergoing isolate OPCABG in our heart center from 2013 through 2020. Fifty-eight patients undergonere-exploration after OPCABG. The 58 patients were divided into death group and survival group according to their discharge status, and the risk factors of death were analyzed.Results: The mortality rate was 27.59% (16/58).We found the patients indeath group had higherbody mass index (BMI) (P=0.03), higher cardiac troponin T (cTnT) (P =0.028) and higher incidence of heart failure before OPCABG (P = 0.003). The levels of lactic acid before and after re-exploration (P =0.011 and P <0.001) were higher in death group. And the levels of creatinine (P = 0.003) and partial pressure of carbon dioxide (PCO2) (P = 0.021) were higher in the death group after re-exploration. The death group had longer reoperation time (P = 0.002).In addition, the perioperative utilization rate of intra-aortic ballon pump (IABP) (P = 0.029), continuous renal replacement therapy (CRRT) (P = 0.001) and platelet transfusion (P = 0.009) were higher than survival group. Conclusions: The mortality rate of patients undergoing re-exploration for bleeding or tamponade after isolate OPCABG is high. More attention should be paid to patients withabove risk factors and appropriate measures should be taken in time.
Selection and Validation of Appropriate Reference Genes for qRT-PCR Analysis of Flowering Stages and Different Genotypes of Iris Germanica L.
Authors: Wang Yinjie , Zhang Yongxia , Liu Qingquan , Tong Haiying , Zhang Ting , Gu Chunsun , Liu Liangqin , Huang Suzhen , Yuan Haiyan 
Published: February 2021

Abstract
Iris germanica L. is a perennial herbaceous plant that has been widely cultivated worldwide and is popular for its elegant and vibrantly colorful flowers. Selection of appropriate reference genes is the prerequisite for accurate normalization of target gene expression by quantitative real-time PCR. However, to date, the most suitable reference genes for flowering stages have not been elucidated in I. germanica. In this study, eight candidate reference genes were examined for the normalization of qRT-PCR in three I. germanica cultivars, and their stability were evaluated by four different algorithms (GeNorm, NormFinder, BestKeeper, and Ref-finder). The results revealed that IgUBC and IgGAPDH were the most stable reference genes in ‘00246’ and ‘Elizabeth’, and IgTUB and IgUBC showed stable expression in ‘2010200’. IgUBC and IgGAPDH were the most stable in all samples, while IgUBQ showed the least stability. Finally, to validate the reliability of the selected reference genes, the expression patterns of IgFT (Flowering Locus T gene) was analyzed and emphasized the importance of appropriate reference gene selection. This work presented the first systematic study of reference genes selection during flower bud development and provided guidance to research of the molecular mechanisms of flowering stages in I. germanica.
The Discovery of Asian Fish Tapeworm (Schyzocotyle Acheilognathi) and Schyzocotyle Sp. In Western Australia May Pose a Threat to the Health of Endemic Native Fishes
Authors: Palermo Cindy Joanna , Morgan David L. , Beatty Stephen J. , Elliot Aileen , Greay Telleasha L. 
Published: February 2021

Abstract
PurposeThe Asian fish tapeworm (Schyzocotyle acheilognathi) is an important fish parasite with a wide host range that infects over 300 species of fish worldwide. Schyzocotyle acheilognathi has been reported from eastern coastal areas of Australia, but has not been previously reported in Western Australia (WA). MethodsDuring a control program for invasive freshwater fishes in south-western WA, a region with a unique and highly endangered freshwater fish fauna, tapeworms identified as S. acheilognathi from their distinctive scolex morphology were found at a prevalence of 3.3% in goldfish (Carassius auratus), 37.0% in koi carp (Cyprinus carpio haematopterus), and 65.0% in eastern mosquitofish (Gambusia holbrooki). For molecular confirmation, the 18S rRNA gene was targeted at hypervariable region V4 using conventional PCR and Sanger sequencing.ResultsKoi carp isolates were 100.0% identical to S. acheilognathi isolated from varying hosts including the red shiner (Cyprinella lutrensis) and a human sample. Sequences from two eastern mosquitofish were identified as S. acheilognathi, but formed a discrete subclass and may represent a novel genotype. Isolates from two other eastern mosquitofish and two goldfish formed a distinct clade with only 91.9% similarity to previously sequenced isolates of S. acheilognathi, indicating a potentially novel Schyzocotyle species. ConclusionThis emphasises the importance of molecular identification methods in addition to morphological identification. The presence and potential for spread of these parasites in south-western WA may threaten the health of native fishes, which are immunologically naïve to this introduced parasite. Immediate control or containment measures should be implemented to halt the spread of these parasites.