bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shock digitalisation of education: The perception of participants of the educational process
Authors: Nazarov V. L. , Zherdev D. V. , Averbukh N. V. 
Published: January 2021

Introduction. The relevance of the study is determined both by the importance of the problem of digital transformation of education in general, and by the specific conditions, which arose during the crisis caused by COVID-19. The long-termconsequences of the emergency transition of Russian education to the distance format, taking into account the ongoing pandemic, have yet to be assessed, but the reaction ofthe participants in the educational process to the first period of the total distance learning should be analysed immediately as a basis for future management decisions.Aim. The aim of the present research is a comprehensive analysis of the perception of the experience of an emergency transition to a distant education format by the main participants in the educational process.Methodology and research methods. Online survey based on Google forms was employed as the main method. The respondents to the survey included participants in the educational process, mostly permanently residing in the Sverdlovsk region (99% of the respondents). The survey was conducted in September – October 2020. The survey participation was voluntary and completely anonymous. As a result of the survey conducted, more than 24,500 original responses were received and processed. The data obtained were compared with the results of secondary studies (primarily, with the monitoring studies of the Higher School of Economics).Results. The research findings demonstrate a number of significant shortcomings in the strategy of digital transformation of education, such as the insufficient development of the digital communication infrastructure in the regions, the technological and competence-based digital inequality, the lack of well-developed methods of using digitaleducational tools, the lack of high-quality content, the lack of full-fledged integrated educational resources on the market. The shortcomings mentioned above apparently led to a decrease in the quality of education during the period of self-isolation and provoked a reaction of rejection of digital educational forms and an increase in technological pessimism among a significant part of the respondents. The results are presented in correlation with secondary studies, which confirms the reliability of the general conclusions.Scientific novelty. The scientific novelty of the research lies in the attraction, systematisation and analytical generalisation of original material on the urgent problem of digital transformation of education, collected in one of the largest and technologically advanced regions of the Russian Federation.Practical significance. The current article makes it possible to more accurately assess the situation in regional education and provides reference points both for conducting longitudinal research and for making current and strategic management decisions in Russian education at the regional and federal level.
Level of Adherence to GOLD Guidelines for Management of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Is There a Difference Between Patient Management in Different Hospital Wards?
Authors: Paknejad Omolbanin , Shiri Akram , Naderpour Zeinab 
Published: January 2021

Background: The purpose of this study was to evaluate the implementation of GOLD guideline in patients with an acute exacerbation of Chronic Obstructive Pulmonary Disease (COPD).
Methods: In a cross-sectional study, all patients with COPD exacerbation referred to Shariati hospital from January 2014 to March 2015 were investigated. The level of adherence to GOLD guideline in three areas of hospital admission, therapeutic components of inpatient management (pharmacologic treatments, respiratory support) and discharge plan was assessed via reviewing patients’ medical profile. Each subject was classified as complete, non-complete and not evaluated in terms of adherence to the guideline.
Results: In this study, 125 patients with mean age of 67.64±1.71 years including 100 (80%) males were studied. Also, 104 and 21 patients were hospitalized in pulmonology and general medicine wards, respectively. In the present study, the adherence to GOLD recommendations for hospital admission, pharmacologic treatment and non-pharmacologic management were 92, 97.6 and 44.2%, respectively. Despite the high level of adherence to pharmacologic management, total adherence to non-pharmacologic interventions was poor.
Conclusion: Although high level of adherence to pharmacological management of COPD was observed, there was overtreatment particularly in case of antibiotics prescription. In addition, non-pharmacological management was not considered in over half of the patients.
Monitoring Prediabetes Screening in Two Primary Care Offices in Rural Appalachia: A Quality Improvement Process
Authors: Clark Rebecca T. , Mullins Christine M. , Hemphill Jean C. 
Published: January 2021

BackgroundOne-third of the U.S. population has prediabetes, but 90% remain undiagnosed because healthcare providers are not screening for this condition.ObjectiveThe purpose of this quality improvement project was to monitor prediabetes screening and identification, and implement evidence-based recommendations including registered dietician referral.MethodsThis project involved using an evidence-based screening tool to measure individual risk of prediabetes. Aggregate data was collected to evaluate screening implementation, evidence-based recommendations offered by providers, and assess patient risk factors.ResultsThe percentage of patients at risk for prediabetes was 41.3% (n = 111). The most frequent risks were identified as overweight, history of hypertension, family history of type 2 diabetes mellitus (T2DM), and older age. Providers offered education on weight loss 68.5% (n = 76) and exercise 76.6% (n = 85) but referred 33.3% (n = 37) patients for nutrition education. The screening rates were 52.3% (n = 176) and 72.5% (n = 244) in clinics A and B respectively.ConclusionsA gap remains in using evidence-based recommendations to decrease risk of prediabetes. Prediabetes screening identified a greater percentage of persons in this population.Implications for NursingThere is a need for consistent practice of evidence-based recommendations. This project set the benchmark for future efforts to educate, encourage, and measure providers successes.
Analisis Tingkat Pelayanan Terminal Transjakarta Pada Stasiun Harmoni Central Busway Berdasarkan Persepsi Penumpang
Authors: Anggoro Aditya Galih , Hadi Winoto , Daryati Daryati 
Published: January 2021

The result of this research show that level of service (LOS) obtained at Harmoni Central Busway Station for Friday July 14th, 2017, corridor which included with category LOS A (very good) was corridor 8A. Then, corridors with category LOS B (good) were corridors 1A, 2, 2A, 3, 5C, and 8, while for corridors with category LOS D (bad) were corridors 1 and 9B. For Monday July 16th, 2017, corridors which included with category LOS A (very good) were corridors 1A, 2, 2A, 3, 5C, 8, and 8A, while for corridors with category LOS C (good enough) were corridors 1 and 9B. For Sunday July 17th, 2017, corridor which included with category LOS A (very good) was corridor 8A. For the next, corridors with category LOS B (good) were corridors 2, 5C, and 8. Then, corridors with category LOS C (good enough) were corridors 1A, 2A, and 3, while for corridors with cateogry LOS D (bad) were corridors 1 and 9B. Value of satisfaction index to 4 factor dimensions of serivce is 66,028%, enter good criteria according to Transjakarta passengers perception at Harmoni Central Busway Station.
Peran Majelis Ulama Indonesia Kabupaten Enrekang dalam Penyadaran Masyarakat Menunaikan Zakat, Infaq, dan Sedekah
Authors: Syandri Syandri , Iskandar Azwar 
Published: January 2021

The aim of this research is to understand the role of Majelis Ulama Indonesia (Ulama Council of Indonesia, MUI) in promoting the fulfilment of zakat, infaq, and sedekah among Muslims in Enrekang Regency. This paper applied descriptive method with qualitative approach. Findings reveal that the MUI of Enrekang Regency has implemented several strategic steps regarding its’ advising and guiding roles pertaining to the fulfilment of zakat, infaq, and sedekah. Those steps are: (1) Advocating the collection of zakat, infaq, and sedekah funds, (2) educating the community about zakat, infaq, and sedekah gradually, (3) maintaining good cooperation with Badan Amil Zakat Nasional (BAZNAS) in the regency, and (4) delivering targeted explanation on the importance of the zakat of profession. Keywords: Infaq, Majelis Ulama Indonesia Enrekang, sedekah, and zakat.
Cost-Effective and Functional Alternatives to Thermanox&nbsp;Cover Rings for Tumor Xenotransplantation on Fertilized Chicken Eggs
Authors: Bauer Sonja , Gladkich Jury , Schäfer Michael , Herr Ingrid 
Published: January 2021

Abstract
Tumor xenotransplantation to the chorioallantois membrane (CAM) of fertilized chicken eggs is excellently suited to short-time analysis of xenograft growth and can reduce mouse experiments. However, the limiting factor with egg xenograft experiments is the high price and limited availability of Thermanox plastic cell culture coverslips, which are often sold out and unavailable for weeks. According to the regular protocol, rings are punched from Thermanox plastic cell culture coverslips 13 mm ø and sticked to the CAM. The xenografts are then sown into these rings in order to prevent that they slide around on the CAM. Thermanox rings are well tolerated and do not interfere with the development of chicken embryos. Here we present a method for preparation of comparable, cheaper and always available alternative rings. We evaluated self-made rings from agar and PVC tube and compared their suitability to Thermanox rings. We found that rings of agar and PVC tube achieved the same xenograft sizes and had no side effects on chick embryonal growth, and therefore seem to be as as good as Thermanox rings.
WITHDRAWN: Health and Human Rights Linkage in Bangladesh: Stakeholders’ views from the grassroots
Authors: Rahman Redwanur , Qattan Ameerah 
Published: January 2021

Abstract
Background: Bangladesh has attained substantial progress in healthcare services and population health. This study examines the knowledge and awareness about the linkage between human rights and healthcare among patients, healthcare providers and members of civil society in Bangladesh. Methods: A questionnaire was distributed between May and August 2018 to 483 respondents among patients (health service users), providers, and other groups (includes members of civil society, politicians, social and religious elites, media personnel, and rights-based groups) in a regional area in Bangladesh. Of these participants, 58% were from urban areas and 42% from rural areas. As many as 78% were male and 22% female. A survey method and descriptive data analysis was performed to complete the study. Results: Participants in the study were aware and had knowledge about the linkage between human rights and health service provision, but they claimed the right to health has not been implemented in practice. The non-implementation of the right to healthcare is suggestive of a lack of political will, which negatively contributes to the social well-being of the larger population. It has undesirable effects on the development of the health system and the population’s health status. This reflects poor monitoring and performance of public institutions which has ramifications on the wider social parameters of social justice, equity, democratic values, transparency, and accountability. Conclusion: The development of population health is rooted in maintaining and promoting the right to healthcare. The ethical principle of human rights lies in the notions of human dignity, equity, equality, and social justice. The government should adhere to these values at societal levels and engage multiple stakeholders to promote the right to health for the benefit of a wider population.
Single Pt atoms on Ru nanoparticles for CO-resistant methanol oxidation reaction electrocatalysis
Authors: Poerwoprajitno Agus , Gloag Lucy , Watt John , Cheong Soshan , Henson Aaron , Subhash Bijil , Bedford Nicholas , Miller Benjamin , O'Mara Peter , Benedetti Tania , Huber Dale , Gooding John , Schuhmann Wolfgang , Tilley Richard 
Published: January 2021

Abstract
Single Pt atom catalysts on non-active carbon supports have been key targets for electrochemical reactions because the high exposure of active Pt leads to record-high activities. PtRu alloy catalysts are the most active for the methanol oxidation reaction (MOR) as the Ru atoms decrease CO poisoning of the active Pt. To combine the exceptional activity of single atom Pt catalysts with the benefits of an active Ru support we must overcome the synthetic challenge of forming single Pt atoms on noble metal nanoparticles. We have developed a concept to grow and spreads Pt islands on faceted Ru branched nanoparticles to make single Pt atom on Ru catalysts. By following the spreading process with in situ TEM, we show that the formation of single atoms is thermodynamically driven by the formation of strong Pt-Ru bonds and a lowering of surface area. The single Pt atom on Ru catalysts successfully limit CO poisoning during MOR to produce record current density and mass activity over time.
Perceptions and Experiences of New Mothers Diagnosed With Tokophobia; Regarding the Quality of Maternal Healthcare Services in Public Hospitals: A Qualitative Study
Authors: Onchonga David , Keraka Margaret , MoghaddamHosseini Vahideh , Várnagy Ákos 
Published: January 2021

Abstract
Background: Quality of maternal care offered in hospitals significantly determines the health outcomes of expectant women and their newborns. The study aimed at understanding the perceptions and experiences of new mothers diagnosed with tokophobia; regarding the quality of maternal services offered in public hospitals in Kenya.Methods: This was a qualitative study consisting of in-depth interviews with 29 women who had given birth recently in a referral hospital in Kenya; and had been screened and found with high fear of childbirth at 22 weeks’ gestation period. The framework for assessing the quality of care of institutional maternity services developed by the University of Southampton was adopted in this study. Thematic analysis was used in this study. Results: The identified challenges were categorized into two: the provision of care and the actual experience of care. In the provision of care, there were perceptions and experiences relating to human and physical resources, inadequate referral systems, and inadequate management of emergencies. In regards to the actual experience of care, there were perceptions and experiences relating to inadequacies in human and physical resources, lack of cognition, lack of respect, dignity and equity, and inadequacies in emotional support.Conclusion: The study identified systemic challenges related to the provision of maternal care and actual experience of care contributing to tokophobia. In this regard, there is a need to judiciously analyze all the critical steps identified in the framework for assessing the quality of maternal care, as this will reduce the intangible challenges identified in this study.
The design of a novel arthroscopy shaver
Authors: Yuan Shiting , Xiao Shanshe , Liu Wentao , Gu Xuelian , Lai Weiguo , Chen Zhi , Liang Peng , Zhao Gaiping 
Published: January 2021

Abstract
Background: Cases of arthroscopic surgery have increased over the past two decades, and arthroscopic shaver systems have become a commonly used orthopedic tool. Nevertheless, most shavers generally have problems such as the cutting edge is not sharp enough and easy to wear. Design and validation: This paper aims to discuss the structural characteristics of BJKMC’s (Bojin◊ Kinetic Medical) novel arthroscopic shaver, the double serrated blade. The product's design and verification process are outlined. BJKMC’s articular arthroscopy shaver has a “tube in a tube” structure, comprising a stainless steel outer sleeve and a rotating hollow inner tube. The outer sleeve and inner tube have corresponding suction and cutting windows, and there are serrated teeth on the inner and outer casing. To verify the design rationality, it was compared to Dyonics◊’s equivalent product, the Incisor◊ Plus Blade. The appearance, cutting tool hardness, metal pipe roughness, cutting tool wall thickness, tooth profile, and angle, overall structure, and the key dimensions were examined and compared.Conclusion: Compared with Dyonics◊’s Incisor◊ Plus Blade, BJKMC’s Double Serrated Blade had a smoother working surface, harder and thinner blade head. Therefore, BJKMC’s product may have satisfactory performance when it comes to surgery.
Undergraduate Medical Education during Coronavirus Disease 2019: Scope and Limitations
Authors: Parveen Mosammat Kohinoor , Hannan Md Jafrul , Ghouri Muhammad Hashim , Anwar Wardah , Arif Muhammad , Naseeb Aeman 
Published: January 2021

Abstract
Background: COVID-19 has highly impacted the education system and has created trends in online classes. To fill in the gap created by lockdown and to continue the uninterrupted learning process, educational institutions worldwide started organizing online classes. Although medical education is mostly practical, it is not safe to conduct on campus classes. This study aimed to measure the scope and limitations of online education and the overall impact of COVID-19 on the medical education system.Methodology: This was a cross-sectional study. Ethical approval was obtained from the ethical committee of the South Point Hospital. Informed consent was obtained. Self-administered questionnaires were administered to participants.Results: E-Learning opportunities were made available in 98.69% of cases; some student forums also participated. Among survey respondents, females predominated (57.39%), and 42% of respondents belonged to rural areas and small towns. Access and quality of internet during online classes was average to poor in 54%, and only 10% said it was good. Zoom was the platform for classes in 98% of situations, followed by Facebook live (41.05%), prerecorded video upload, YouTube link, etc. Sixty percent graded the quality of online classes as good, 10% excellent, and 5% bad. Approximately 43% of the participants evaluated online assessments as good. Of the respondents, 17% faced substantial stress, and 18% did not. Twenty-eight percent of the students faced huge mental stress during COVID-19.Conclusions: E-learning is a new normal during the COVID-19 pandemic. Given the opportunity, medical students benefited greatly, but there was a technological divide. There were also financial and mental stresses to a certain extent.
&nbsp;Genome-wide Analysis of Long Noncoding RNA Expression Profile in Nasal Mucosa with Allergic Rhinitis
Authors: Wei Xian , Xu Man , Wang Chao , Fang Shengjian , Zhang Yu , Wang Weihua 
Published: January 2021

Abstract
Background: Long noncoding RNAs (lncRNAs) are involved in a variety of human immune diseases. However, the expression profile and precise function of lncRNAs in allergic rhinitis (AR) remain unknown. In the present study, genome-wide analysis of lncRNA expression was performed in the nasal mucosa tissue and mRNA regulatory relationship was examined among patients with or without AR. Methods: Microarray assays were performed and the differential expressions of lncRNAs or mRNA were verified through RT-PCR. The lncRNA functions were annotated using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). The potential regulatory relationships between lncRNAs and the co-expressed mRNAs were analyzed using Cytoscape software. The expressions of specific lncRNAs and mRNAs were examined using an in vitro cell model. Results: A total of 57 lncRNAs and 127 mRNAs were dysregulated in the nasal mucosa tissue of patients with AR, compared to those of patients without AR (fold change ＞2.0 and P ＜0.05). GO and pathway analysis indicated that the lncRNA–co-expressed mRNAs were enriched in several biological processes and cellular signaling pathways related to AR, such as positive regulation of the integrin biosynthetic process, cell adhesion, and leukocyte transendothelial migration. Some lncRNAs regulated the co-expressed genes in a cis- and/or trans-regulatory manner. Furthermore, allergen exposure significantly increased the expression of lnc-CXCL12-4, CXCL12, and CXCR4 in BEAS-2B cells compared to untreated cells (P ＜0.01). Conclusion: The results of the present study suggest that lncRNAs participate in the biological pathways related to AR. Leukocyte transepithelial migration may be a potential target for lncRNAs to regulate allergic inflammation and CXCL12/CXCR4 axis plays an important role in the inflammatory process of AR.
Human Amniotic Mesenchymal Stem Cells Inhibit aGVHD in Humanized NPG Mice by Regulating Balance of Treg Versus T Effector Cells
Authors: Gao Ya , Li Weiru , Bu Xiaoyin , Xu Ying , Cai Shengchun , Zhong Jinman , Du Meixue , Sun Haitao , Huang Liping , He Yongjian , Hu Xiumei , Liu Qifa , Jin Hua , Wang Qian , Ping Baohong 
Published: January 2021

Abstract
Background: Acute graft versus host disease(aGVHD) occurs when immunocompetent T cells in the donated tissue recognize the recipient as foreign after allo-HSCT, which can severely affect quality of life. Although previous studies indicated that MSC may be a salvage therapeutic agent for aGVHD, the mechanism is not yet fully clear. The aim of this study was to explore the therapeutic efficacy and underlying mechanisms of hAMSCs transplantation for humanized aGVHD mouse model.Methods: We established a novel xenogeneic (xeno)-aGVHD humanized mouse models by transplanting purified human T cells from peripheral blood into immunodeficient NOD-PrkdcscidIl2rγnull (NPG) mouse. In those mouse models, lymphocyte infiltration of target organs was detected by HE staining method and immunohistochemistry respectively. The biological characteristics of hAMSCs were investigated. hAMSCs labeled with GFP were administered to NPG mice to explore the homing ability of hAMSCs. Mice are divided into normal(control) group, aGVHD group and hAMSCs treatment group. After 3 days of injection of PBMC, hAMSCs and PBS were given into the different groups. T effector and Treg cells levels of each group in target organs were detected by flow cytometry and cytometric bead array (CBA).Results: We successfully established xenogeneic aGVHD “humanized model” by using NOD-PrkdcscidIl2rγnull (NPG) mice, which showed lymphocytes infiltration in the liver, spleen and lung. hAMSCs therapy improved systemic inflammation and inhibited aGVHD in humanized mouse through reduced villous blunting and lymphocyte infiltration into the lamina propria of the gut while reducing vascular endothelialitis and lymphocyte infiltration into the parenchyma of the liver and lung. In addition, hAMSCs suppresses xenogenesis CD3+/CD4+ and CD3+/CD8+ T cell concentration and increases the proportion of Treg cells. Our data also show that hAMSC can reduce the level of IL-17A, INF-γ, TNF and IL-2 that involved in the pathogenesis of aGVHD target organs.Conclusions: NPG murine environment is capable of activating human T cells to produce aGVHD pathology to mimic aGVHD in humans. hAMSCs controlled aGVHD by decreasing inflammatory cytokine secretion within target organs through modulating balance of Treg versus T effector cells in humanized mice.