bluuebunny/crossref_metadata_2025_split huggingface dataset:
Governance nell’innovazione: Sanità Digitale, Mobile Health, Big Data, Virtual Reality
Authors: Burrai Francesco , Micheluzzi Valentina , Apuzzo Luigi 
Published: April 2021

The introduction of modern Information and Communication Technologies (ICT) was one of the most remarkable innovations of recent decades. ICT brings with it a remarkable technological background that conveys all kinds of information and multimedia content with a significant change in human-technology interaction and significant implications also in the health sector. The constant process of digitization is increasingly affecting national health systems (SSN) and they turn out to be influenced by the process itself, where the literature shows itself in favor of the use of technologies in health, improving their effectiveness and efficiency. These include eHealth, Telemedicine, Electronic Health File, Big Data, Virtual Reality, Augmented Reality, ePrescription. The technologies allow, even remotely, to have an always active and direct contact, between the various professionals, and between professionals and users, and are also useful for the training of both healthcare professionals and users themselves. The use of technology in the healthcare sector should therefore be encouraged as it allows direct contacts between users and healthcare personnel, speed and correlation of data analysis, tracking, time and cost savings, reduction of errors and a positive environmental impact with a reduction in the use of printed paper. For all the points listed, the technological revolution in hospital and territorial care can no longer be postponed.
Synthesis of triazole-containing ciprofloxacin conjugate and its in silico test as a cytochrome P450 ligand
Authors: Фалетров Ярослав Вячеславович , Глинская Лилия Игоревна , Хорецкий Матвей Сергеевич , Панада Ян Владимирович , Фролова Нина Степановна , Шкуматов Владимир Макарович 
Published: April 2021

Cytochromes P450 are hem-containing monooxygenases which catalyse biosynthesis of many compounds playing an essential role in cellular functions as well as degradation of drugs and xenobiotics. Some P450s (e. g., human CYP19 and CYP17, fungal CYP51) are valid target proteins for some drugs. The others P450s are also interesting for pharmacology-related researches. Aiming to design new fluorescent inhibitor of P450s we have synthesised the azole-bearing conjugate of ciprofloxacin (CPF-bab-Z1). To estimate potential of the compound as a ligand for CYPs we performed high-throughput virtual screening (multiple docking calculations) for CPF-bab-Z1 and multiple known 3D structures of P450s. The best affinity for CPF-bab-Z1 (the smallest value of energy of binding is equal -12.5 kcal/mol) were found for protein with PDB code 5esh among 28 structures of CYP51. The calculated pose of CPF-bab-Z1 in the active site of the protein is characterised by cyclopropyl (but not azole) proximity to the heme iron of the CYP51. The data obtained demonstrate perspectives for in vitro investigations of CPF-bab-Z1 with P450s.
Керамічний комплекс Борисфена періоду ранньої архаїки (за матеріалами колекції В.В. Лапіна)
Authors: Gavrylyuk Nadiya 
Published: April 2021

У статті йдеться про керамічний комплекс перших поселенців на о. Березань і визначення ролі ліпного посуду у ньому. Вирішується питання кому належала ліпна кераміка з матеріалів найраніших шарів Борисфену – варварам чи грекам. Джерельною базою статті є матеріал з колекції В.В. Лапіна. Показані перспективи використання статистичних методів у вивченні масового керамічного матеріалу. Показана різниця між керамічними комплексами об’єктів, котрі були створені «до стихійного лиха» та «після стихійного лиха» у межах другої половина VII – початку VI ст. до н.е.
Outcomes After Repair of Pulmonary Atresia With Ventricular Septal Defect and Major Aortopulmonary Collateral Arteries: A Tailored Approach in a Developing Setting
Authors: Zou Ming-Hui , Ma Li , Cui Yan-Qing , Wang Huai-Zhen , Li Wen-Lei , Li Jia , Chen Xin-Xin 
Published: April 2021

Objectives: Pulmonary atresia with ventricular septal defect and major aortopulmonary collateral arteries (PA/VSD/MAPCAs) is complex and diverse that has led to a variety of treatment strategies. Experience has been largely obtained in the advanced countries. The clinical diversity is greater in China. We evaluated our surgical approaches and outcomes of these patients.Methods: We reviewed 127 patients undergoing varied surgeries in our center in 2010–2019.Results: Thirty patients underwent single-stage complete repair by unifocalizing MAPCAs and VSD closure (aged 3.9–131.4 months, median 22) with 3 (10%) early deaths. Ninety-seven underwent the first-stage rehabilitation strategy including systemic-to-pulmonary shunt in 29 (aged 0.5–144 month, median 8), and palliative RV-PA conduit in 68 (aged 2.2–209.6 months, median 14) with 5 (5.2%) early deaths. Eight-one patients (63.8%) eventually achieved complete repair with a median right/left ventricular (RV/LV) pressure ratio of 0.7 (ranged 0.4–1.0). Fourteen patients (11.0%) accepted palliation as final destination. Survival for the entire cohort was 89.5, 85.2, and 76.1% at 1, 5, and 10 years, respectively. Survival for those undergoing complete repair was 88.2 and 76.6% at 1 and 5 year, respectively. RV/LV pressure ratio ≥0.8 was risk factor for mortality (HR10.3, p = 0.003).Conclusions: Our cohort, the largest from China, had distinctive clinical features with substantially wider age range and higher RV/LV pressure ratio. Using the combined approaches tailored to individual patients, complete repair was achieved in 64% of patients. The early and intermediate outcomes are acceptable compared to many of the previous reports.
Can Inhibin B Reflect Ovarian Reserve of Healthy Reproductive Age Women Effectively?
Authors: Wen Jingyi , Huang Kecheng , Du Xiaofang , Zhang Hanwang , Ding Ting , Zhang Cuilian , Ma Wenmin , Zhong Ying , Qu Wenyu , Liu Yi , Li Zhiying , Deng Song , Luo Aiyue , Jin Yan , Zhang Jinjin , Wang Shixuan 
Published: April 2021

ObjectiveThe reference range and potential value of inhibin B are still unclear and controversial. This study aimed to define the variation trend of inhibin B in healthy women with age and explore its value in the reflection of ovarian reserve.MethodsA total of 2524 healthy reproductive age women from eight medical institutes nationwide were recruited. The variation tendency of inhibin B with age was primarily established in the first group of 948 women and validated in another 605. We evaluated the relationship between inhibin B and classic ovarian reserve and function markers. The potency of inhibin B in predicting AFC &lt;5-7 was also estimated and compared with FSH.ResultsThe nomogram showed that serum levels of inhibin B rapidly decreased after the age of 40. Inhibin B was positively correlated with AMH (R = 0.57, P &lt; 0.001), AFC (R = 0.34, P &lt; 0.001) and testosterone (R = 0.10, P = 0.002), and negatively correlated with FSH (R = -0.41, P &lt; 0.001) and LH (R = -0.20, P &lt; 0.001) and FSH/LH (R=-0.18, P &lt; 0.001), while no correlation was found with PRL. Unexpectedly, Inhibin B (AUC = 0.74, P &lt; 0.001 for the establishment population; AUC = 0.78, P &lt; 0.001 for the validation population) had a slightly higher value than FSH (AUC = 0.71, P &lt; 0.001 for the establishment population; AUC = 0.72, P &lt; 0.001 for the validation population) in diagnosing AFC &lt;5-7.ConclusionsFor healthy reproductive age women, the decline of inhibin B can reflect decreased ovarian reserve effectively, having a good consistency with AMH and AFC. More importantly, inhibin B had an advantage in predicting AFC &lt;5-7 compared with FSH, which suggested the potential of inhibin B in predicting ovarian response. These results will be helpful to the clinical application of inhibin B in the evaluation of female ovarian reserve and the assessment of their reproductive capacity. Trial registration: http://clinicaltrials.gov; NCT02294500.
Electrochemical Double-Layer Capacitor Containing Mixtures of Ionic Liquid, Lithium Salt, and Organic Solvent as an Electrolyte
Authors: Li Xiangyuan , Li Hao , Feng Rui , He Long , Lu Hai 
Published: April 2021

A modified ionic liquid (IL)-based electrolyte, with conventional carbonates as the support solvent and lithium salt as the additive, was designed for a high-voltage electrochemical double-layer capacitor (EDLC). It is found that the employment of carbonate solvents enhances the ionic conductivity and decreases the viscosity of the electrolyte. At the same time, the addition of lithium salt plays a key role in the stabilization of the operating potential window and the modification of the passivation layer on the electrode. As a result, increased specific capacitance, improved cycle stability, and rate capability are demonstrated in the EDLC with an EMI-BF4/LiPF6/PC/DMC electrolyte at the upper voltage of 3 V, in contrast to that with pure IL and IL/carbonate mixture. This study primarily stresses the combination effect of Li salt and organic solvent in an IL electrolyte system for constructing advanced 3 V-class EDLC with excellent overall performance.
Performance Evaluation of BD Phoenix NMIC-413 Antimicrobial Susceptibility Testing Panel for Imipenem, Meropenem, and Ertapenem Against Clinical Carbapenem-Resistant and Carbapenem-Susceptible Enterobacterales
Authors: Zhang Jingjia , Jia Peiyao , Zhu Ying , Zhang Ge , Xu Yingchun , Yang Qiwen 
Published: April 2021

Purpose: The infection of carbapenem-resistant Enterobacterales (CRE) has become a major clinical and healthcare problem worldwide. The screening methods of CRE have been extensively developed but still need improving [e.g., tests with accurate and simple minimum inhibitory (MICs)]. In this study, the performance of the BD Phoenix NMIC-413 AST panel was evaluated against clinical CRE and carbapenem-susceptible Enterobacterales (CSE) in China. The panel was first evaluated in the Chinese clinical lab.Methods: Antimicrobial susceptibility testing of 303 clinical Enterobacterales isolates were conducted by broth microdilution (BMD), Phoenix NMIC-413 AST panel, and disk diffusion method for imipenem, ertapenem, and meropenem. Considering BMD is a gold standard, essential agreement (EA), categorical agreement (CA), minor error (MIE), major error (ME), and very major error (VME) were determined according to CLSI guidelines. CA and EA &gt; 90%, ME &lt;3%, and VME &lt;1.5% were considered as acceptable criteria. Polymerase chain reaction and sanger sequencing were performed to determine the β-lactamase genotypes of CRE isolates.Results: Three hundred and three isolates included 195 CREs and 108 CSEs were enrolled according to the BMD-MIC values of three carbapenems. Tested CREs showing 100 blaKPC−2-positive organisms, 31 blaIMP-positive organisms, 28 blaNDM-positive organisms, 5 blaVIM-positive organisms, 2 both blaIMP and blaVIM-positive organisms, 2 blaOXA−48-positive organisms, and 27 isolates without carbapenemase genes. For the Phoenix NMIC-413 method, CA and EA rates &gt;93%, MIE rates &lt;5%, ME rates &lt;1.75%, and VME rates were 0%, across the three drugs. For the disk diffusion method, the CA rates for three drugs were all &gt;93%, while the MIE and ME rates were all &lt;5 and &lt;3%, respectively. VME rate was 3.28% for imipenem, exceeded the cut-off value specified by CLSI M52, 0 and 0.56% for ertapenem and meropenem, separately.Conclusion: Based on the genomic data, the detection of CRE and CSE was more reliable using the BD Phoenix NMIC-413 panel compared to the BMD and disk approaches. Therefore, our study supports the use of BD Phoenix NMIC-413 panel as a suitable alternative to BMD for the detection of carbapenem resistant isolates in a clinical setting.
Examining the Research Criteria for Traumatic Encephalopathy Syndrome in Middle-Aged Men From the General Population Who Played Contact Sports in High School
Authors: Iverson Grant L. , Merz Zachary C. , Terry Douglas P. 
Published: April 2021

Objective: There are no validated or agreed upon diagnostic clinical criteria for chronic traumatic encephalopathy or traumatic encephalopathy syndrome. This study examines the leading research criteria for traumatic encephalopathy syndrome (TES) in middle-aged men in the general population.Method: Participants were 409 men between the ages of 35 and 55 recruited through an online crowdsourcing platform. Participants provided demographic information, medication history, concussion history, contact sport history, current medication use, and current symptoms. Research criteria for TES were applied to the sample.Results: Over half of the total sample met TES symptom criteria (56.2%), without applying the neurotrauma exposure criteria. Those with 4+ prior concussions had higher rates of meeting TES criteria compared to those with 0–3 prior concussions, but the results were not statistically significant (69.8 vs. 54.6%; χ2 = 3.58, p = 0.06). Exposure to contact sports was not related to higher rates of TES (ps ≥ 0.55). In a binary logistic regression predicting the presence of mild or greater TES, significant predictors were sleep difficulties [Odds ratio (OR) = 6.68], chronic pain (OR = 3.29), and age (OR = 1.04). Neurotrauma exposure was not a significant predictor (p = 0.66). When analyzing those with no prior concussions or contact sport histories (n = 126), 45.2% met symptom criteria for mild or greater TES; chronic pain and sleep difficulties were associated with a higher prevalence of meeting criteria for TES in this subgroup (ps &lt; 0.001).Conclusions: Men who participated in contact sports in high school or college were not more likely to meet criteria for TES than men who participated in non-contact sports or no sports. In a multivariable model, sleep problems and chronic pain were predictive of meeting the symptom criteria for TES, but the repetitive neurotrauma exposure criterion was not a significant predictor of meeting the TES symptom criteria.
Association of Birth Order With Mental Health Problems, Self-Esteem, Resilience, and Happiness Among Children: Results From A-CHILD Study
Authors: Fukuya Yoshifumi , Fujiwara Takeo , Isumi Aya , Doi Satomi , Ochi Manami 
Published: April 2021

Objective: This study aimed to investigate the association of birth order with mental health problems, self-esteem, resilience, and happiness among children aged 9–10 years.Methods: This was a cross-sectional study using data from the Adachi Child Health Impact of Living Difficulty (A-CHILD) study, which was a population-based study of children in fourth grade in public schools in Adachi City, Tokyo, Japan in 2018 (N = 3,744). Parent-rated Strengths and Difficulties Questionnaire (SDQ) and self-rated resilience, happiness, and self-esteem score were used to assess child mental health. Multiple regression analysis for continuous outcomes and logistic regression for dichotomous outcomes were used to examine the association of birth order with mental health problems, resilience, happiness, and self-esteem. The analysis was controlled for child sex, mother's age, mother's education, caregiver's depressive symptoms, household income, and living with grandparents.Results: Last-borns showed the lowest total difficulties score in the SDQ, while only children showed the highest (p &lt; 0.001). The highest prosocial behaviors score was found among last-borns (p &lt; 0.001). Resilience score was also highest among last-borns, followed by first-borns, middle-borns, and only children. The lowest happiness score was found among middle-borns. Self-esteem score did not differ by sibling types. These associations were similar in the adjusted model and dichotomized outcomes model.Conclusions: Differential impacts of birth order on child mental health, for both positive and negative sides, were found. Further research is warranted to elucidate the mechanism of the association between birth order and the development of behavior problems and the positive aspects such as resilience, happiness, and self-esteem among children.
AI-Based Estimation of End-Systolic Elastance From Arm-Pressure and Systolic Time Intervals
Authors: Bikia Vasiliki , Adamopoulos Dionysios , Pagoulatou Stamatia , Rovas Georgios , Stergiopulos Nikolaos 
Published: April 2021

Left ventricular end-systolic elastance (Ees) is a major determinant of cardiac systolic function and ventricular-arterial interaction. Previous methods for the Ees estimation require the use of the echocardiographic ejection fraction (EF). However, given that EF expresses the stroke volume as a fraction of end-diastolic volume (EDV), accurate interpretation of EF is attainable only with the additional measurement of EDV. Hence, there is still need for a simple, reliable, noninvasive method to estimate Ees. This study proposes a novel artificial intelligence—based approach to estimate Ees using the information embedded in clinically relevant systolic time intervals, namely the pre-ejection period (PEP) and ejection time (ET). We developed a training/testing scheme using virtual subjects (n = 4,645) from a previously validated in-silico model. Extreme Gradient Boosting regressor was employed to model Ees using as inputs arm cuff pressure, PEP, and ET. Results showed that Ees can be predicted with high accuracy achieving a normalized RMSE equal to 9.15% (r = 0.92) for a wide range of Ees values from 1.2 to 4.5 mmHg/ml. The proposed model was found to be less sensitive to measurement errors (±10–30% of the actual value) in blood pressure, presenting low test errors for the different levels of noise (RMSE did not exceed 0.32 mmHg/ml). In contrast, a high sensitivity was reported for measurements errors in the systolic timing features. It was demonstrated that Ees can be reliably estimated from the traditional arm-pressure and echocardiographic PEP and ET. This approach constitutes a step towards the development of an easy and clinically applicable method for assessing left ventricular systolic function.
Xogo de reflexividades
Authors: Marey-Castro Cristina 
Published: April 2021

Nunha investigación anterior1, propuxérame reflexionar sobre o que acontece cos prexuízos na interpretación social, en particular en contextos estigmatizados como as situacións de violencia de xénero e as situacións de prostitución. Para iso, valérame de fontes documentais que proviñan dos estudos da interpretación e do campo da psicoterapia, no que dera con algúns conceptos que me permitiran nomear certos procesos que, dende o meu punto de vista, se poñen en xogo no encontro entre as intérpretes e as persoas interpretadas. Ora ben, malia que non desboto a utilidade dese enfoque nun primeiro achegamento, o obxectivo desta proposta é moverse dese marco e suxerir a antropoloxía social como un campo do que botar man para analizar as experiencias da interpretación sen perder o eixe da estrutura social e da axencia das persoas interpretadas. A través do diálogo multidisciplinario con fontes documentais e con estudos da antropoloxía social, dos estudos da interpretación e da tradución e da socioloxía, propoño a reflexividade (Guber, 2001, 2004 [1991]) como unha categoría frutífera a partir da que pensar as interaccións na interpretación social, un labor antropolóxico.
Biophenology peach twig borer (Anarsia lineatella Zell.) in the south of Ukraine
Authors: Klechkovskyi Yu. , Yudytska І. 
Published: April 2021

Goal. Clarification of certain biological features of development and seasonal dynamics of the flight of peach twig borer in peach orchards of the Southern Steppe of Ukraine.
Methods. Field — research of the biological features of peach twig borer development using pheromone-trap method was conducted in accordance with generally accepted methods in peach orchards of SPS “Naukova” of Melitopol fruit growing research station named after M.F. Sydorenko of IH of NAAS of Ukraine
Results. It was determined that in the conditions of peach orchards in the South of Ukraine restoration of feeding peach twig borer caterpillars began in the end of March — the middle of April, and the hatching — in the end of April — the beginning of May. During 2018—2020, the beginning of the flight of butterflies of the pest was observed starting from 06 to 18 May, with the accumulation of the sum of effective temperatures (SET) >8°С 154.5—254.3 and lasted continuously until September 18—30 (134—141 days) with three peaks. The appearance of the pest caterpillars was observed from the 2—3rd ten-day period of May (SET>8°С 299.0—349.5°С). The peaks of peach twig borer flight were observed in the 3rd ten-day period of May, late June — early July, and during the 3rd ten-day period of July — mid-August. The duration of the development of the first generation was 44—50 days, the next — 30—40 days, with accumulation of SET>8°С from imago to imago varying between 436.5 and 743.0°С.
Conclusions. In the south of Ukraine, three peaks of flight and development of two full generations of peach twig borer are noted, caterpillars of the third generation completed the development in the spring of the following year. Fluctuations in the number of imago during the growing season were influenced by both meteorological factors and the degree of reproduction of the pest of the previous generation. During the years of research, the highest intensity of catching of butterflies of a fruit striped moth was noted in July — August at high mean weakly air temperatures (25.0—26.9°С) and the conditions of severe drought (HTC 0.2).
Analytical control of active substances of the class of imidazolinones in herbicide formulations
Authors: Cherviakova L. , Panchenko T. , Borzykh O. 
Published: April 2021

Goal. The choice of a chromatographic method and the development of a method for the analytical determination of imazethapyr, imazamox, imazapyr in herbicide preparative forms in the joint presence.
Methods. Active substances were analyzed by thin layer chromatography. The linear range of the dependence of the area of chromatographic zones on the amount of active substance was assessed by a mathematical-statistical method.
Results. Determination of pesticides by thin-layer chromatography includes the main stages: classification of pesticides by polarity; extraction of active substances from the analyzed sample; chromatographic separation, detection and quantification. The decisive factor in the analysis stages is the dipole moment (μ, D), which characterizes the polarity of the compounds. Imazethapyr, imazamox and imazapir are polar compounds (μ≥6, D) with the corresponding values: 6.1; 6.4 and 6.8 D. Extraction of active substances is carried out with ethanol. Qualitative determination — in a thin layer of adsorbent silica gel in the mobile phase: a mixture of ethanol with acetic acid in a ratio of 4 : 1.5. Identify compounds at the wavelength of the spectrum λ 254 nm and using the developing reagent silver ammonia. The calibration dependence of the area of the chromatographic zone of the compound on its amount is linear in the detection range of 0.30—1.30 μg and is described by the regression equations for: imazethapyr S = 12.345 C + 0.7778, R2 = 0.99; imazapyr S = 9.3671 C + 1.081, R2 = 0.99; imazamox S = 7.6234 C + 1.4462, R2 = 0.98. The equation is used to quantify the active ingredients in the chromatogram.
Conclusions. The use of the method of thin layer chromatography makes it possible to select selective conditions for the analysis of imazethapyr, imazamox, and imazapyr in the presence of herbicides in preparative forms. The developed technique is an express method of control and provides determination of active substances in the course of one analysis with high accuracy (relative error is less than 5% at n = 5, P = 0.95). The analytical support of the developed and patented method allows for analytical control of active substances of the imidazolinone class in the formulation of pesticides by analytical and toxicological laboratories, testing services without the use of expensive devices.