bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accounting for skew when post-processing MOGREPS-UK temperature forecast fields
Authors: Allen Sam , Evans Gavin R , Buchanan Piers , Kwasniok Frank 
Published: June 2021

AbstractWhen statistically post-processing temperature forecasts, it is almost always assumed that the future temperature follows a Gaussian distribution conditional on the output of an ensemble prediction system. Recent studies, however, have demonstrated that it can at times be beneficial to employ alternative parametric families when post-processing temperature forecasts, that are either asymmetric or heavier-tailed than the normal distribution. In this article, we compare choices of the parametric distribution used within the Ensemble Model Output Statistics (EMOS) framework to statistically post-process 2m temperature forecast fields generated by the Met Office’s regional, convection-permitting ensemble prediction system, MOGREPS-UK. Specifically, we study the normal, logistic and skew-logistic distributions. A flexible alternative is also introduced that first applies a Yeo-Johnson transformation to the temperature forecasts prior to post-processing, so that they more readily conform to the assumptions made by established post-processing methods. It is found that accounting for the skewness of temperature when post-processing can enhance the performance of the resulting forecast field, particularly during summer and winter and in mountainous regions.
Effectiveness of Parenting Training on Emotional and Behavioral Problems in First through Fourth Grade Thai Children with ADHD: A Randomized Controlled Study
Authors: Tiwawatpakorn Nichanan , Worachotekamjorn Juthamas , Tassanakijpanich Nattaporn 
Published: June 2021

Objective To evaluate the effectiveness of parenting training on emotional and behavioral problems of first through fourth grade Thai children with ADHD compared with routine clinical care in a university hospital in southern Thailand. Material and methods Caregivers of the children were invited and assessed for eligibility. Eighty children with ADHD were randomly assigned to either a parenting training group or a routine clinical care group. The primary caregivers of the parenting training group participated in 6 120-minute weekly sessions in addition to routine clinical care. Caregiver and teacher ADHD ratings and oppositional-defiant disorder ratings were collected at the time of enrollment and after the 6 weeks of training in both groups. The differences in scores in both groups were analyzed using a mixed model ANOVA. Results Each arm had 40 participants. The mean (SD) age of the children was 8.3 (1.1) years and their mean (SD) age at the first diagnosis of ADHD was 6.8 (1.3) years. Most of them were receiving methylphenidate for treatment of their ADHD. The mother was the primary caregiver for 83.5% of the children. The ADHD symptoms and oppositional-defiant symptoms showed significant improvement after receiving the treatment in both groups; however, no significant differences were found between groups. Conclusion Adding parenting training to the routine clinical care for children with uncomplicated ADHD who are being medicated was not more effective than the routine clinical care alone. However, the power of this study is limited, and follow-up is needed to evaluate the long-term effectiveness.
Imputation of Missing Covariate Data Prior to Propensity Score Analysis: A Tutorial and Evaluation of the Robustness of Practical Approaches
Authors: Leite Walter L. , Aydin Burak , Cetin-Berber Dee D. 
Published: June 2021

Background: Propensity score analysis (PSA) is a popular method to remove selection bias due to covariates in quasi-experimental designs, but it requires handling of missing data on covariates before propensity scores are estimated. Multiple imputation (MI) and single imputation (SI) are approaches to handle missing data in PSA. Objectives: The objectives of this study are to review MI-within, MI-across, and SI approaches to handle missing data on covariates prior to PSA, investigate the robustness of MI-across and SI with a Monte Carlo simulation study, and demonstrate the analysis of missing data and PSA with a step-by-step illustrative example. Research design: The Monte Carlo simulation study compared strategies to impute missing data in continuous and categorical covariates for estimation of propensity scores. Manipulated conditions included sample size, the number of covariates, the size of the treatment effect, missing data mechanism, and percentage of missing data. Imputation strategies included MI-across and SI by joint modeling or multivariate imputation by chained equations (MICE). Results: The results indicated that the MI-across method performed well, and SI also performed adequately with smaller percentages of missing data. The illustrative example demonstrated MI and SI, propensity score estimation, calculation of propensity score weights, covariate balance evaluation, estimation of the average treatment effect on the treated, and sensitivity analysis using data from the National Longitudinal Survey of Youth.
COVID‐19 in the Clinic: Aerosol Containment Mask for Endoscopic Otolaryngologic Clinic Procedures
Authors: Ference Elisabeth H. , Kim Wihan , Oghalai John S. , Kim Jee‐Hong , Applegate Brian E. 
Published: June 2021

ObjectiveTo create an aerosol containment mask (ACM) that contains aerosols during common otolaryngologic endoscopic procedures while protecting patients from environmental aerosols.Study DesignBench testing.SettingMannequin testing.MethodsThe mask was designed in SolidWorks and 3‐dimensional printed. Mannequins were fitted with a nebulizer to generate aerosols. Commercial particle counters were used to measure mask performance.ResultsThe ACM has 2 ports on either side for instruments and endoscopes, a port for a filter, and a port that can evacuate aerosols contained within the mask via a standard suction pump. The mask contained aerosols on a mannequin with and without facial hair when the suction was set to 18.5 L/min. Other types of masks demonstrated substantial aerosol leakage under similar conditions. In a subsequent experiment, the ACM contained aerosols generated by a nebulizer up to the saturation of the particle detector without measurable leakage with or without suction.ConclusionThe ACM will accommodate rigid and flexible endoscopes plus instruments and prevent leakage of patient‐generated aerosols, thus avoiding contamination of the room and protecting health care workers from airborne contagions.Level of evidence2.
Physical activity, emotional state and socialization in the elderly: study protocol for a clinical multicentre randomized trial
Authors: Ruiz-Comellas Anna , Sauch Valmaña Glòria , Mendioroz Peña Jacobo , Roura Poch Pere , Sabata Carrera Anna , Cornet Pujol Irene , Gómez Baena Isabel , Casaldàliga Solà Àngels , Saldaña Vila Carme , Fusté Gamisans Montserrat , Boix De la Casa Carme , Rodoreda Pallàs Berta , Ramirez-Morros Anna , Vazquez Abanades Lorena , Vidal-Alaball Josep 
Published: June 2021

Objective To evaluate whether a 4-month physical activity (PA) group program and visits to sociocultural organizations improve emotional state, social support levels and health-related quality of life in elderly individuals with depression and/or anxiety and/or loneliness. Methods This will be a multicentre, randomized, two-group clinical trial with a 1-year follow-up. Participants will be 150 primary care patients aged >64 years allocated equally to a control group and an intervention group. Inclusion criteria are Beck Depression Inventory (BDI-II) score ≥14 and/or General Anxiety Disorder (GAD-7) scale score ≥10 and/or Duke-UNC-11 scale score ≥32. The intervention group will participate in a 4-month group PA program. The program will comprise two walks per week and a monthly visit to a sociocultural facility. Results Measured outcomes are clinical remission of depression (BDI-II score <14) and anxiety (GAD-7 scale score <10), improved social support (reduction in DUKE-UNC-11 score), improved quality of life and/or response to the intervention at 4 and 12 months post-intervention. Intervention satisfaction and adherence and post-intervention links with sociocultural organizations will also be assessed. Conclusion The findings could encourage the provision of activity-based community interventions for older individuals.
Achieving Successful Outcomes in High-Level Athletes With Borderline Hip Dysplasia Undergoing Hip Arthroscopy With Capsular Plication and Labral Preservation: A Propensity-Matched Controlled Study
Authors: Jimenez Andrew E. , Monahan Peter F. , Miecznikowski Kara B. , Saks Benjamin R. , Ankem Hari K. , Sabetian Payam W. , Lall Ajay C. , Domb Benjamin G. 
Published: June 2021

Background: Return to sports (RTS) rates and patient-reported outcomes (PROs) after hip arthroscopy in athletes with borderline dysplasia (BD) have not been established. Purpose: (1) To report minimum 2-year PROs and RTS rates in high-level athletes with BD who underwent hip arthroscopy for labral pathology in the setting of microinstability and (2) to compare clinical results with those of a matched control group of athletes with normal acetabular coverage. Study Design: Cohort study; Level of evidence, 3. Methods: Data were reviewed for surgery performed between January 2012 and July 2018. Patients were considered eligible if they received a primary hip arthroscopy in the setting of BD (lateral center-edge angle, 18°-25°) and competed in professional, collegiate, or high school sports. Inclusion criteria included preoperative and minimum 2-year follow-up scores for the modified Harris Hip Score, Non-arthritic Hip Score, Hip Outcome Score–Sport Specific Subscale, and visual analog scale for pain. Athletes with BD were matched to a control group of athletes with normal acetabular coverage (lateral center-edge angle, 25°-40°). Results: A total of 65 patients with BD were included in the study with a mean ± standard deviation follow-up of 47.5 ± 20.4 months. Athletes with BD showed significant improvement in all outcome measures recorded, demonstrated high RTS rates (80.7%), and achieved the minimal clinically important difference (MCID) and Patient Acceptable Symptom State (PASS) for the Hip Outcome Score–Sport Specific Subscale at high rates (MCID, 90.8%; PASS, 75.4%). When compared with a propensity-matched control group with normal acetabular coverage, capsular plication was performed more commonly in the BD group (93.8% vs 82.7%; P = .037). PROs and RTS, PASS, and MCID rates were similar between the BD and control groups ( P > .05). Conclusion: High-level athletes with BD who undergo primary hip arthroscopy for labral pathology in the setting of microinstability may expect favorable PROs and RTS rates at minimum 2-year follow-up. These results were comparable with those of a control group of athletes with normal coverage.
Predictors of Lower Depression Levels in Older Adults During COVID-19 Lockdown
Authors: Bohn Lucimere , Gomes Sérgio , Neto Elzier Sampaio de Queiroz , Lage Ana Carolina Silveira de Souza , de Freitas Maria das Dores Bezerra , Magalhães Fabíola de Paula , Mota Jorge , Soares Miranda Luisa 
Published: June 2021

Background Social distancing during the COVID-19 pandemic may lead to adverse mental health consequences, such as depression, among older adults. This study aimed to investigate the predictors of lower depression scores in older adults living under lockdown. Methods 1,123 older Brazilian adults were cross-sectionally assessed for depression, physical activity (PA), pet ownership (dogs, cats, and birds), ability to make video calls, leaving home during lockdown, and not living alone. The statistical procedures included linear regression and analysis of covariance (ANCOVA). Results After adjusting for age, sex, and race, moderate to vigorous PA (β = −0.014, p < .001), it was found that PA (β = −0.905, p < .001) and dog ownership (β = −0.545, p = .004) were associated with lower depression. No association was observed between depression and other conditions. Conclusions With the likelihood of subsequent COVID-19 waves, remotely delivered PA programs might be a strategy to counteract the negative psychological effects of lockdown on older adults.
Efficacy of Low-Intensity Cognitive Behavior Intervention for Chinese Delinquent Youth
Authors: Zhuang Xiaoyu , Lau Yin Yim , Huang Yu-Te , Tam Cherry Hau Lin , Chan Wilson Man Ho , Yeung Kenneth Kin Wa , Ng Ting Kin , Wong Daniel Fu Keung 
Published: June 2021

Purpose: Recent literature has pointed out the seriously unmet treatment needs of delinquent youth with mental health problems in Hong Kong. This study pioneers to systematically develop and evaluate the effectiveness of a structured low-intensity cognitive behavioral intervention (LICBI) to concurrently address mental health issues and delinquent behaviors among Hong Kong Chinese youth. Method: A quasi-experimental controlled design was adopted with three assessments at baseline, postintervention, and 6-week follow-up. One hundred and eighty participants were recruited to the LICBI and 123 to the control group. Results: Multilevel modeling analyses showed that the LICBI might be effective in improving mental health–related factors (impulsivity, self-esteem, negative emotions, and loneliness) and delinquent behaviors. A mediation analysis suggested that LICBI might reduce participants’ delinquent behaviors through reducing their impulsivity and enhancing their self-esteem. Discussion: The results provide preliminary evidence for the effectiveness of LICBI for Chinese delinquent youth in a community social service setting.
A Retrospective Study of 52 Patients With Primary Small Cell Carcinoma of the Esophagus Treated With Radical Surgery
Authors: Fan Ningbo , Wang Zhen , Huang Yuanheng , Tan Zihui , Yang Han , Lin Peng 
Published: June 2021

Background: Primary small cell carcinoma of the esophagus (SCCE) is a rare and extremely fatal disease. We aim to evaluate the efficacy of radical surgery for resectable SCCE and to explore potential prognostic factors. Methods: We retrospectively reviewed 52 consecutive SCCE patients who underwent radical surgery from February 1993 to November 2014 at a single institution. The Kaplan-Meier estimator with log-rank test was used to assess overall survival (OS), disease-free survival (DFS) and median survival time. Univariate and multivariable analyses were used to evaluate prognostic factors through Cox proportional hazard regression model. Results: Twenty-five (48.1%) patients were treated with surgery alone, whereas 27 (51.9%) patients underwent adjuvant therapy after surgery. The median OS time was 17.4 months (95% CI: 13.5-21.3). The median DFS time was 13.4 months (95% CI: 7.7-19.0). Patients whose tumors were located in the lower part of thoracic esophagus and the esophagogastric junction showed significantly better OS (27.0 vs. 13.2 months, P = 0.016) and DFS (27.0 vs. 11.3 months, P = 0.017) than those located in the upper and middle parts. Patients with N0 status experienced significantly better OS (21.4 vs. 11.6 months, P = 0.012) and DFS (21.4 vs. 8.6 months, P = 0.012) than those with N+ status. Patients whose tumor lengths were shorter than 5 cm had a better OS (17.4 vs. 5.7 months, P = 0.035) than those longer than 5 cm. Patients who underwent chemotherapy experienced a significantly improved OS (21.0 vs. 14.1 months, P = 0.032) compared to surgery alone. Multivariable analysis showed that lower tumor location, shorter tumor length, pN0 status and chemotherapy independently predicted better OS; lower tumor location and pN0 status independently predicted better DFS. Conclusions: Radical surgery in combination with chemotherapy has better outcomes than surgery alone for resectable SCCE. Higher tumor location, longer tumor length, lymph node metastasis and not undergoing chemotherapy independently predict worse prognoses.
Caregiver-Reported Burden in RE-KINECT: Data From a Prospective Real-World Tardive Dyskinesia Screening Study
Authors: Cutler Andrew J. , Caroff Stanley N. , Tanner Caroline M. , Shalhoub Huda , Lenderking William R. , Pagé Véronique , Franey Ericha , Yonan Chuck 
Published: June 2021

Background: RE-KINECT (NCT03062033), a real-world study of possible tardive dyskinesia (TD) in antipsychotic-treated patients, included a questionnaire to assess the effects of patients’ abnormal involuntary movements on caregivers. Aims: To capture the experiences of caregivers who assisted individuals with abnormal involuntary movements that were confirmed by clinicians as being consistent with TD. Methods: Qualified (nonpaid) caregivers were invited to complete a questionnaire that included the following: caregivers’ sociodemographic characteristics, their perceptions about the impact of abnormal involuntary movements on patients, and the impact of these movements on themselves (caregivers). Results: Of the 41 participating caregivers, 25 (61.0%) were women, 20 (48.8%) were employed full time or part time, and 35 (85.4%) were family members or friends. Based on responses from caregivers who noticed patients’ abnormal involuntary movements and were caring for individuals who also noticed those movements, 48.0% of patients had “a lot” of severity in ≥1 body region and 76.0% had abnormal involuntary movements in ≥2 regions. Caregiver ratings were significantly correlated with patient ratings (but not with clinician ratings) for maximum severity of abnormal involuntary movements and the number of affected regions (both p <.05). Based on their own judgments and perceptions, caregivers reported that the patient’s movements had “some” or “a lot” of impact on their (caregiver’s) ability to continue usual activities (50.0%), be productive (58.3%), socialize (55.6%), or take care of self (50.0%). Conclusions: Caregivers as well as patients are negatively affected by TD, and the impact of TD on caregivers’ lives should be considered when determining treatment options.
L1 congruency, word frequency, collocational frequency, L2 proficiency, and their combined effects on Chinese–English bilinguals’ L2 collocational processing
Authors: Fang Nan , Zhang Ping 
Published: June 2021

Aims: The current study investigated the effects of first language (L1) congruency, word frequency, collocational frequency, second language (L2) proficiency, and their combined effects on L2 collocational processing. Methodology: Twenty English native speakers and 60 adult Chinese–English bilinguals (intermediate and advanced) completed an online phrasal decision task. They made a judgment about whether target word pairs (congruent collocations, incongruent collocations, and non-collocational baseline items) were commonly used in English. Data and analysis: Response time and accuracy data were analyzed with mixed-effects models, with focus on the interactions of the variables of interest. Findings: Results demonstrated differential effects for the response time and accuracy data: (1) both L2 groups were significantly more accurate but not significantly faster in judging the congruent collocations than the incongruent collocations, and unexpectedly similar patterns were observed with the L1 group; (2) all participants were sensitive to word frequency and collocational frequency, but they differed in the manner and degree of such sensitivity; and (3) the processing of incongruent collocations showed greater combined effects of word frequency and collocational frequency than did the processing of congruent collocations. Originality: We specifically investigated the effects of multiple influencing factors and their combined effects. In addition, we addressed a methodological limitation regarding stimuli control by using congruent and incongruent collocational pairs that differed in only one constituent word. Implications: Our findings highlight the non-colinear relationship of L2 proficiency and (explicit and implicit) collocational knowledge as well as the semantic aspects of cross-language differences, and they also support the usage-based models.
Registration of catheter-related complications in adverse events reporting systems: a major underestimation of the real complication practice
Authors: Laan Bart J , Godfried Mieke H , Geerlings Suzanne E 
Published: June 2021

Reporting and learning from preventable adverse events is crucial to improve patient safety. Although physicians should file and analyse adverse events by law in The Netherlands, it is unknown if these reporting systems are sufficiently used in clinical practice. This study is a substudy of the multicenter RICAT trial, a successful quality improvement project to reduce inappropriate use of intravenous and urinary catheters in medical wards in seven hospitals, in which we screened 5696 patients and documented 803 catheter-related complications. We also checked the adverse events reporting systems of these patients and found that only 13 (1.6%) of 803 catheter-related complications were registered. Of the infectious complications only five (10.9%) of 46 catheter-associated bloodstream infections and urinary tract infections were registered. We conclude that the reported complications were a major underestimation of the real complication practice in medical wards in The Netherlands. The RICAT trial is registered at Netherlands Trial Register, trial NL5438.
Rush immunotherapy in two cats with atopic skin syndrome
Authors: Jones Selene , Bloom Paul 
Published: June 2021

Case series summary Two cats with feline atopic skin syndrome (FASS) were included in this case series. They were diagnosed with FASS by a combination of history, physical examination and exclusion of other pruritic diseases. They underwent rush immunotherapy (RIT) after determination of offending environmental allergens by either serum IgE or intradermal testing. Cats were premedicated with an antihistamine and hospitalized for the day to undergo the procedure and to ensure adequate observation. Allergen extracts were administered subcutaneously at increasing concentrations every 30 mins until the maintenance dose of 20,000 protein nitrogen units/ml was reached. Both cats successfully completed RIT without any adverse reactions and their clinical signs improved afterwards. RIT appears to be an alternative treatment option for cats with FASS. Larger studies are needed to more accurately assess the safety and long-term efficacy of RIT in the feline patient, as well as the incidence of adverse reactions and optimal premedication protocol. Further evaluation of the route of injections for RIT is also warranted. Relevance and novel information RIT has been reported to be a safe treatment option in canine atopic dermatitis. Its use in FASS is limited to a pilot study of four cats. The purpose of this series was to describe two additional cats that underwent RIT using a different premedication protocol.