bluuebunny/crossref_metadata_2025_split huggingface dataset:
ImmunAL: a frame to identify the immunological markers for Mild Moderated Alzheimer’s Disease applying Multiplex Network Model
Authors: Sen Sagnik , Chatterjee Agneet , Maulik Ujjwal 
Published: October 2021

AbstractIdentification of immunological markers for neurodegenerative diseases resolve issues related to diagnostic and therapeutic. Neuro-specific cells experience disruptive mechanisms in the early stages of disease progression. The autophagy mechanism, guided by the autoantibodies, is one of the prime indicators of neurodegenerative diseases. Identifying autoantibodies can show a new direction. Detecting influential autoantibodies from relational networks viz., co-expression, co-methylation, etc. is a well-studied area. However, none of the studies have considered the functional affinity among the autoantibodies while selecting them from a relational network. In this regard, a twolayered multiplex network based framework has been proposed, whereby the layers consist co-expression and co-semantic scores. The networks have been formed using three distinct cases viz., diseased, controlled, and a combination of both. Subsequently, a random walk with restart mechanism has been applied to identify the influential autoantibodies, where layer switching probability and restart probability are 0.5 and 0.4 respectively. Next, pathway semantic network has been formed considering the autoantibody associated pathways. EPO and IL1RN, associated with a maximum number of pathways, are identified as the two most influential autoantibodies. The network also provides insights into possible molecular mechanisms during the pathogenic progression. Finally, MDPI and CNN3 are also identified as important biomarkers.AvailabilityThe code is available athttps://github.com/agneet42/ImmunAL
Strategies and lessons learnt from user involvement in researching quality and safety in nursing homes and homecare
Authors: Aase Ingunn , Ree Eline , Johannessen Terese , Holen-Rabbersvik Elisabeth , Thomsen Line Hurup , Strømme Torunn , Ullebust Berit , Schibevaag Lene , Lyng Hilda Bø , O'Hara Jane , Wiig Siri 
Published: October 2021

PurposeThe purpose is to share strategies, rationales and lessons learnt from user involvement in a quality and safety improvement research project from the practice field in nursing homes and homecare services.Design/methodology/approachThis is a viewpoint paper summarizing how researchers and co-researchers from the practice field of nursing homes and homecare services (nurse counsellors from different municipalities, patient ombudsman and next-of-kin representatives/and elderly care organization representant) experienced user involvement through all phases of the research project. The project included implementation of a leadership intervention.FindingsMultiple strategies of user involvement were applied during the project including partnership in the consortium, employment of user representatives (co-researchers) and user-led research activities. The rationale was to ensure sound context adaptation of the intervention and development of tailor-made activities and tools based on equality and mutual trust in the collaboration. Both university-based researchers and Co-researchers experienced it as useful and necessary to involve or being involved in all phases of the research project, including the designing, planning, intervention implementation, evaluation and dissemination of results.Originality/valueUser involvement in research is a growing field. There is limited focus on this aspect in quality and safety interventions in nursing homes and homecare settings and in projects focussing on the leadership' role in improving quality and safety.
Information literacy as a site for anticipation: temporal tactics for infrastructural meaning-making and algo-rhythm awareness
Authors: Haider Jutta , Sundin Olof 
Published: October 2021

PurposeThe article makes an empirical and conceptual contribution to understanding the temporalities of information literacies. The paper aims to identify different ways in which anticipation of certain outcomes shapes strategies and tactics for engagement with algorithmic information intermediaries. The paper suggests that, given the dominance of predictive algorithms in society, information literacies need to be understood as sites of anticipation.Design/methodology/approachThe article explores the ways in which the invisible algorithms of information intermediaries are conceptualised, made sense of and challenged by young people in their everyday lives. This is couched in a conceptual discussion of the role of anticipation in understanding expressions of information literacies in algorithmic cultures. The empirical material drawn on consists of semi-structured, pair interviews with 61 17–19 year olds, carried out in Sweden and Denmark. The analysis is carried out by means of a qualitative thematic analysis in three steps and along two sensitising concepts – agency and temporality.FindingsThe results are presented through three themes, anticipating personalisation, divergences and interventions. These highlight how articulating an anticipatory stance works towards connecting individual responsibilities, collective responsibilities and corporate interests and thus potentially facilitating an understanding of information as co-constituted by the socio-material conditions that enable it. This has clear implications for the framing of information literacies in relation to algorithmic systems.Originality/valueThe notion of algo-rhythm awareness constitutes a novel contribution to the field. By centring the role of anticipation in the emergence of information literacies, the article advances understanding of the temporalities of information.
Management's knowledge filter: entrepreneurship theory and the historic conceptual evolution of opportunism in management studies
Authors: Muldoon Jeffrey , Bendickson Joshua S. , Gur Furkan A. , Murphy Patrick J. 
Published: October 2021

PurposeThis study aims to argue that opportunism is central to management thought and illustrate its evolution into a central element of the entrepreneurship theory. The authors show that many criticisms of opportunism tend to conflate the concept with other theoretic traditions.Design/methodology/approachThe authors trace foundational works by Taylor, Mayo, Fayol, Barnard, Follett and Simon to limit opportunism under the guise of promoting cooperation in organizations.FindingsOpportunism is conceptualized in transaction cost economics as one of the most controversial concepts in management. While modern management is based on handling opportunism, it is bad for practice, as it ignores innovation, and damages trust and goodwill among organizational members. These interventions serve as a knowledge filter, damaging organizational entrepreneurship.Originality/valueBy tracing the roots of opportunism in early management thought, the authors clarify ethical and entrepreneurial issues of mutual obligations in organizations. The authors also place workplace conflict to be a more coherent framework that better reflects the core concept of opportunism.
A turnaround fuelled by transformational leadership
Authors: Sengupta Mayuree 
Published: October 2021

PurposeThe purpose of this paper is to understand how Chairman and Managing Director (CMD) of the National Research Development Corporation, India, Hanumanthu Purushotham had facilitated a turnaround of the organization and ensured profitability during his tenure there. This is one of the series of interview-based studies that focuses on a South Asian CEO, with the goal of ascertaining his leadership and management style in a volatile situation. This brief paper expounds how leader traits and transformational leadership can positively impact an organizational turnaround and fuel growth.Design/methodology/approachThis paper uses primary interviews and complements the findings with secondary data sources such as annual reports and management literature on leadership trait, transformational leadership and organizational turnaround.FindingsThe study found that socioeconomic factors have a bearing on leadership attributes. In this instance, the CMD's early years, diverse work experiences, bright traits and transformational leadership positively impacted organizational performance. Therefore, not only the qualifications but also the qualities of a leader are pivotal in shaping success of an organization.Originality/valueThe narrative provides an instance of how decision-making driven by strategic leadership can change firm performance. The rich experiences of the India-educated CMD, a government job holder all-through, provides a veteran's view to decision-making in a state-controlled firm and helps us understand how an organization can be transformed in a limited time and with scarce resources.
Turning old foes into new allies—Harnessing drainage canals for biodiversity conservation in a desiccated European lowland region
Authors: Tölgyesi Csaba , Torma Attila , Bátori Zoltán , Šeat Jelena , Popović Miloš , Gallé Róbert , Gallé‐Szpisjak Nikolett , Erdős László , Vinkó Tamás , Kelemen András , Török Péter 
Published: October 2021

AbstractDrainage canals are widespread components of agricultural landscapes. Although canals have greatly contributed to biodiversity loss by desiccating wetlands, they have recently attracted conservation attention due to their potential to function as refugia for native species in intensively managed landscapes. However, their conservation role in complex landscapes composed of agricultural fields and desiccated but otherwise untransformed, semi‐natural habitats, on which canals still pose a heavy burden, is unknown. Improved understanding of drainage canals and related biodiversity in these landscapes could help unlock their potential and support synergistic land management for nature conservation and water resource management.We applied a multi‐taxon approach, including plants, butterflies, true bugs, spiders and birds, to (a) assess the conservation value of drainage canals with temporary water cover in a heavily drained European lowland region, (b) to test landscape‐level and local canal parameters for aiding prioritization among canals and (c) to propose a reconciliation‐based management framework that suits the interest of all stakeholders.We found that drainage canals and their banks concentrate more species across most taxa than semi‐natural, mostly grassland habitats, possibly due to micro‐environmental heterogeneity and the absence of low‐intensity annual management compared to grasslands. Canals traversing semi‐natural grasslands concentrate particularly high numbers of native species, but agricultural canals also support remarkable species richness. However, agricultural canals are important dispersal corridors for non‐native invasive plants, which may negatively affect native biodiversity. Canal size has little effect on biodiversity, but habitat stress is an important determinant. The higher the stress (due to sandiness and salinity), the higher the added value of canals to landscape‐wide biodiversity.Synthesis and applications. We show that drainage canals can harbour high biodiversity and should therefore be recognized as important novel ecosystems with high conservation value, even when cutting through semi‐natural grassland habitats. Canals have previously been considered detrimental to nature conservation due to their association with loss of wetlands. However, by reducing water loss with reversible obstructions, controlling invasive species and applying specific conservation measures, they may be turned into conservation allies without compromising long‐term interests of water management and agricultural land use.
The Anaesthetic Politics of Being Unaffected: Embodying Insecure Digital Platform Labour
Authors: Bissell David 
Published: October 2021

AbstractBuilding on critical geographic research on the embodied politics of labour that has explored how different forms of work transform bodily capacities for action, this paper argues that a body’s capacity to be affected is an overlooked aspect of a labouring body’s power. In response, the paper develops the concept of anaesthesia in relation to work by explaining how a reduced capacity to be affected can be both politically constraining and enabling for the bodies involved. Through qualitative fieldwork with digital platform workers, the paper presents three narratives that express the embodied complexities of this insecure work. Concealment, projection and resignation are explored as anaesthetic bodily tactics that constitute a refusal to inhabit certain depleting experiences. By drawing attention to such survival strategies, the paper highlights how workers’ changing capacities for feeling are just as significant for understanding worker agency as their changing capacities for action.
Combined biomechanical and tomographic keratoconus staging: Adding a biomechanical parameter to the ABCD keratoconus staging system
Authors: Flockerzi Elias , Vinciguerra Riccardo , Belin Michael Wellington , Vinciguerra Paolo , Ambrósio Renato , Seitz Berthold 
Published: October 2021

AbstractPurposeThis retrospective cross‐sectional study evaluated the potential of an additional biomechanical parameter ‘E’ as an addition to the tomographic ABCD ectasia/keratoconus (KC) staging.MethodsThe Corvis Biomechanical Factor (CBiF) represents the modified linear term of the Corvis Biomechanical Index (CBI) developed based on 448 KC corneas from the Homburg Keratoconus Center (HKC). The CBiF range was divided into five stages (E0 to E4) to create a grading system according to the ABCD stages. Stage E0 was characterized by values smaller than the 2.5 percentile. The thresholds were created by dividing the CBiF range between the 2.5 and 97.5 percentiles into four groups of equal values (E1–E4). The frequency distribution of ‘E’ was analysed and independently validated based on another 860 KC corneas dataset from Milano and Rio de Janeiro (MR). The relationship between ‘E’ and the ABCD staging was analysed by cross‐tabulation. The specificity of ‘E’ was assessed based on healthy controls (112|851) from both datasets (HKC|MR).Results‘E’ was normally distributed with E0 = 37|30, E1 = 86|200, E2 = 155|354, E3 = 101|206, E4 = 69|70 in the KC group and 96.4%|90.5% of the controls classified E0 in the HKC|MR dataset, respectively. Cross‐tabulation revealed that ‘E’ was most comparable to posterior corneal curvature (‘B’) in both datasets, while showing a trend towards more advanced stages in comparison to anterior corneal curvature (‘A’) and thinnest corneal thickness (‘C’).ConclusionThe novel Corvis‐derived parameter ‘E’ provides a biomechanical staging for ectasia/KC potentially enhancing the ABCD staging and may detect abnormalities before tomographic changes, which requires further studies.
Molecular margin status after radical prostatectomy using glutathione S‐transferase P1 (GSTP1) promoter hypermethylation
Authors: Witt Jörn H. , Friedrich Maria , Jandrig Burkhard , Porsch Markus , Baumunk Daniel , Liehr Uwe‐B. , Wendler Johann J. , Schostak Martin 
Published: October 2021

ObjectiveTo assess the potential for molecular staging in biopsies of the prostatic fossa after radical prostatectomy (RP) by searching for occult tumour cells through analysis of glutathione S‐transferase P1 (GSTP1) methylation status.Patients and MethodsWe analysed 2446 biopsies: 2286 biopsies from a group of 254 patients with clinically organ‐confined prostate cancer who underwent RP and 160 biopsies from a control group of 32 patients. After prostate gland excision, biopsies were obtained from defined areas of the prostatic fossa and bisected for histopathological and molecular genetics analyses. Results were related to clinicopathological data including tumour stage, lymph node status, resection status, tumour grading, initial PSA level, and biochemical recurrence.ResultsIn total, 34 patients (13.4%) had at least one core positive for the GSTP1 promoter hypermethylation, six of whom (17.6%) were characterised as having a clinically localised tumour stage (pT2, pN0) and 28 (82.4%) as an advanced tumour stage (≥pT3 and/or pN1). GSTP1 promoter hypermethylation significantly correlated with tumour stage (P < 0.001), International Society of Urological Pathology grading (P = 0.001), lymph node status (P < 0.001), surgical margin status (P < 0.001), and biochemical recurrence (P = 0.001). Furthermore, in 46 patients (18.1%) further analysis led to a down‐ or upgrading of conventional surgical margin status. Classical R‐status (margins of the specimen) is significantly superior to histological sampling from the fossa (P = 0.006) but not to GSTP1 analysis from the fossa (P = 0.227).ConclusionFor the detection of residual tumour in the fossa after RP in order to better predict recurrence, molecular GSTP1 promoter hypermethylation has some value; however, the classical R‐status (margins of the specimen) is simpler and more widely applicable with similar results.
The demand effect analysis of head books and tail books in book recommendation networks
Authors: Kim Jae Kyeong , Jeong Chang Geun , Li Qinglong , Choi Il Young 
Published: October 2021

AbstractMany existing studies related to recommendation systems have made great efforts to increase performance‐oriented evaluation metrics such as accuracy, recall, F1 value, MAE, diversity, and so on. However, these metrics for measuring performance do not provide any explanation of how such recommendation systems contribute to a product provider's sales. Recently, to investigate the factors affecting product sales, researchers have started to use the product recommendation network, which is a graphical presentation of the relationship between products that are purchased simultaneously. In this research, we are going to identify factors that influence the demand for head books (top sales books) and tail books (non‐top sales books) in academic and technology books, because the characteristics of specialized books are different from those of general books. To test the model, online sales data of medicine and science books of G Publishing, the leading medical book publishing and distribution company in Korea, are used. We employ social network analysis and multiple regression analysis to investigate demand effect of the book recommendation network. The former is used to measure centralities of the book recommendation network, while the latter is used to measure the demand effect. Furthermore, we inspect whether there are different attributes between head books and tail books that are related to the book demand in recommendation networks. This study is the first attempt to examine the demand effect of the recommendation network of academic and technology books. The following results are obtained general book sales of an online bookstore follow a long‐tail law, while sales of academic and technology books follow Pareto's law distribution. This study investigated attributes that might be linked to demand effect of head books and tail books in the recommendation network of academic and technology books. How to increase book sales using attributes that are differently associated with the demand of head books and tail books in the recommendation network is also presented.
Nonwearable actigraphy to assess changes in motor activity before and after rescue analgesia in terminally ill patients with cancer: A pilot study
Authors: Higami Yoko , Higuchi Akarai , Tanaka Haruka , Moriki Yuki , Utsumi Momoe , Yamakawa Miyae , Ito Yuri , Hatano Yutaka , Maeda Isseki , Fukui Sakiko 
Published: October 2021

AbstractAimsThis study aimed to investigate the usefulness of nonwearable actigraphy to assess changes in motor activity before and after rescue analgesic administration in terminally ill cancer patients.BackgroundEvaluating pain in terminally ill cancer patients is difficult; pain assessment tools are needed.MethodsThis was an exploratory descriptive study conducted within a palliative care unit. A nonwearable actigraph was used to measure the activity score and movement index of terminally ill patients with weeks‐long prognosis and pain. The actigraph and medical data were integrated, and data were compared 6 h before and after rescue analgesic administration.ResultsAmong 10 patients (age: 75.8 ± 12.3 years; six men), we evaluated 28 pain episodes (mean activity score: 130.9 ± 180.5 counts per minute; movement index: 68.8%). When pain was relieved at night following rescue analgesic administration, activity score and movement index decreased significantly (6 h before vs. 6 h after analgesics, respectively: 113.1 to 69.7 counts per minute; 64.3% to 41.8%; both p < 0.0001). With no relief after rescue analgesic administration, activity score did not differ significantly 6 h before and after analgesics: 147.3 to 137.7 counts per minute.ConclusionPain in terminally ill cancer patients could be assessed using a nonwearable actigraph to capture motor activity and improve pain assessment.
Influence of Zn2+ doping on the morphotropic phase boundary in lead‐free piezoelectric (1 – x)Na1/2Bi1/2TiO3‐xBaTiO3
Authors: Bremecker Daniel , Lalitha K. V. , Teuber Siegfried , Koruza Jurij , Rödel Jürgen 
Published: October 2021

AbstractA series of morphotropic phase boundary (MPB) compositions of (1–x)Na1/2Bi1/2TiO3‐xBaTiO3 (x = 0.05, 0.055, 0.06, 0.065, 0.07), with and without 0.5 mol% Zn‐doping was synthesized using the solid‐state route. The samples were characterized using X‐ray diffraction, dielectric analysis, and electromechanical measurements (piezoelectric d33 coefficient, coupling factor kp, mechanical quality factor Qm, and internal bias field Ebias). The increase in the ferroelectric‐relaxor transition temperature upon Zn‐doping was accompanied by a shift of the MPB toward the Na1/2Bi1/2TiO3‐rich side of the phase diagram. Higher tetragonal phase fraction and increased tetragonal distortion were noted for Zn‐doped (1 – x)Na1/2Bi1/2TiO3‐xBaTiO3. In addition, ferroelectric hardening and the presence of an internal bias field (Ebias) were observed for all doped compositions. The piezoelectric constant d33 and the coupling coefficient kp decreased by up to ∼30%, while a 4‐ to 6‐fold increase in Qm was observed for the doped compositions. Apart from establishing a structure–property correlation, these results highlight the chemically induced shift of the phase diagram upon doping, which is a crucial factor in material selection for optimal performance and commercialization.