bluuebunny/crossref_metadata_2025_split huggingface dataset:
Specific exposure of ICU staff to SARS-CoV-2 seropositivity: a wide seroprevalence study in a French city-center hospital
Authors: Vivier Emmanuel , Pariset Caroline , Rio Stephane , Armand Sophie , Doroszewski Fanny , Richard Delphine , Chardon Marc , Romero Georges , Metral Pierre , Pecquet Matthieu , Didelot Adrien 
Published: May 2021

Abstract
Background
Most hospital organizations have had to face the burden of managing the ongoing COVID-19 outbreak. One of the challenges in overcoming the influx of COVID-19 patients is controlling patient-to-staff transmission. Measuring the specific extent of ICU caregiver exposure to the virus and identifying the associated risk factors are, therefore, critical issues. We prospectively studied SARS-CoV-2 seroprevalence in the staff of a hospital in Lyon, France, several weeks after a first epidemic wave. Risk factors for the presence of SARS-CoV-2 antibodies were identified using a questionnaire survey.

Results
The overall seroprevalence was 9% (87/971 subjects). Greater exposure was associated with higher seroprevalence, with a rate of 3.2% [95% CI 1.1–5.2%] among non-healthcare staff, 11.3% [8.9–13.7%] among all healthcare staff, and 16.3% [12.3–20.2%] among healthcare staff in COVID-19 units. The seroprevalence was dramatically lower (3.7% [1.0–6.7%]) in the COVID-19 ICU. Risk factors for seropositivity were contact with a COVID-19-confirmed household (odds ratio (OR), 3.7 [1.8–7.4]), working in a COVID-19 unit (OR, 3.5 [2.2–5.7], and contact with a confirmed COVID-19 coworker (OR, 1.9 [1.2–3.1]). Conversely, working in the COVID-19-ICU was negatively associated with seropositivity (OR, 0.33 [0.15–0.73]).

Conclusions
In this hospital, SARS-CoV-2 seroprevalence was higher among staff than in the general population. Seropositivity rates were particularly high for staff in contact with COVID-19 patients, especially those in the emergency department and in the COVID-19 unit, but were much lower in ICU staff.
Clinical trial registration NCT04422977
Discontinuation rate and associated factors among contraceptive implant users in Kersa district, southwestern Ethiopia
Authors: Nega Gali , Abera Muluemebet , Tadele Afework 
Published: May 2021

AbstractBackgroundSubdermal contraceptive implant is the most widely used method of long-acting reversible contraception among Ethiopian women. Many, however, discontinue use early, which results in unwanted pregnancies and induced abortions and their associated complications. The aim of this study is to determine the rate of and reasons for discontinuation of the contraceptive implant among users in the Kersa district of southwestern Ethiopia.MethodsA mixed-method study was carried out between March and April 2019 among 475 women who had been using the contraceptive implant between January 2015 and August 2016 in the Kersa district. Systematic random sampling was used for quantitative data collection and purposive sampling was used for qualitative data collection using 8 focus group discussion and 56 In-depth interviews. A binary logistic regression was carried out for bivariate and multivariable analyses.ResultsOne hundred and ten (23.2 %) contraceptive implant users requested removal before 2.5 years of use. The main reasons for the discontinuation were side effects, followed by a desire for pregnancy or to switch to another contraceptive method and misconceptions. Implant discontinuation was associated with a lack of information prior to insertion on the effectiveness of modern contraception (adjusted odds ratio [OR] 2.0; 95 % confidence interval [CI] 1.13, 3.55), being served by a midwife or nurse (adjusted OR 1.8; 95 % CI 1.04, 3.23), and not being told to return to the health facility if any side effects were experienced (adjusted OR 1.8; 95 % CI 1.01, 3.19) (allp < 0.05).ConclusionsAlmost a quarter of the study participants discontinued use of the contraceptive implant before the due date. Public health interventions should focus on providing adequate awareness for family planning users, trainings for the health care workers on effective counselling services, especially on side effect and misconceptions.
Strain engraftment competition and functional augmentation in a multi-donor fecal microbiota transplantation trial for obesity
Authors: Wilson Brooke C. , Vatanen Tommi , Jayasinghe Thilini N. , Leong Karen S. W. , Derraik José G. B. , Albert Benjamin B. , Chiavaroli Valentina , Svirskis Darren M. , Beck Kathryn L. , Conlon Cathryn A. , Jiang Yannan , Schierding William , Holland David J. , Cutfield Wayne S. , O’Sullivan Justin M. 
Published: May 2021

Abstract
Background
Donor selection is an important factor influencing the engraftment and efficacy of fecal microbiota transplantation (FMT) for complex conditions associated with microbial dysbiosis. However, the degree, variation, and stability of strain engraftment have not yet been assessed in the context of multiple donors.

Methods
We conducted a double-blinded randomized control trial of FMT in 87 adolescents with obesity. Participants were randomized to receive multi-donor FMT (capsules containing the fecal microbiota of four sex-matched lean donors) or placebo (saline capsules). Following a bowel cleanse, participants ingested a total of 28 capsules over two consecutive days. Capsules from individual donors and participant stool samples collected at baseline, 6, 12, and 26 weeks post-treatment were analyzed by shotgun metagenomic sequencing allowing us to track bacterial strain engraftment and its functional implications on recipients’ gut microbiomes.

Results
Multi-donor FMT sustainably altered the structure and the function of the gut microbiome. In what was effectively a microbiome competition experiment, we discovered that two donor microbiomes (one female, one male) dominated strain engraftment and were characterized by high microbial diversity and a high Prevotella to Bacteroides (P/B) ratio. Engrafted strains led to enterotype-level shifts in community composition and provided genes that altered the metabolic potential of the community. Despite our attempts to standardize FMT dose and origin, FMT recipients varied widely in their engraftment of donor strains.

Conclusion
Our study provides evidence for the existence of FMT super-donors whose microbiomes are highly effective at engrafting in the recipient gut. Dominant engrafting male and female donor microbiomes harbored diverse microbial species and genes and were characterized by a high P/B ratio. Yet, the high variability of strain engraftment among FMT recipients suggests the host environment also plays a critical role in mediating FMT receptivity.

Trial registration
The Gut Bugs trial was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12615001351505).

Trial protocol
The trial protocol is available at https://bmjopen.bmj.com/content/9/4/e026174.
A meta-analysis on educational technology in English language teaching
Authors: Rahmati Jafar , Izadpanah Siros , Shahnavaz Ali 
Published: May 2021

AbstractAs more various types of computer-assisted language learning (CALL) programs have been incorporated into language classrooms over the recent decades, it has become more important to uncover whether, to what extent, and under which moderator variables CALL can be yield more effective outcomes than traditional language instruction. The issue of education is one of the most important materials addressed by technology. Instead, meta-analysis is a statistical and quantitative method that leads us to a general conclusion by integrating the results of different researches. In this study, researchers worked on the impact of educational technology in English language teaching by studying 67 articles and theses (from 1000 studies that were relevant in title and abstract). All articles and theses were included from 2009 to 2020 and 7 articles were excluded from this study due to insufficient information. Furthermore, two instruments, SPSS (mainly its sub-branch Kruskal-Wallis test) and CMA were used to calculate and evaluate data in this research. The total effect size calculated for studies under both fixed and random models was statistically significant and also the study of effects by year of publication, instruments used in research and research methods showed that their effect size was significant. Teaching English with the help of technology has an effective effect size and has shown the success of this technology in language learning.
Premorbid β1-selective (but not non-selective) β-blocker exposure reduces intensive care unit mortality among septic patients
Authors: Kuo Ming-Jen , Chou Ruey-Hsing , Lu Ya-Wen , Guo Jiun-Yu , Tsai Yi-Lin , Wu Cheng-Hsueh , Huang Po-Hsun , Lin Shing-Jong 
Published: May 2021

Abstract
Background
β-blockers may protect against catecholaminergic myocardial injury in critically ill patients. Long-term β-blocker users are known to have lower lactate concentrations and favorable sepsis outcomes. However, the effects of β1-selective and nonselective β-blockers on sepsis outcomes have not been compared. This study was conducted to investigate the impacts of different β-blocker classes on the mortality rate in septic patients.

Methods
We retrospectively screened 2678 patients admitted to the medical or surgical intensive care unit (ICU) between December 2015 and July 2017. Data from patients who met the Sepsis-3 criteria at ICU admission were included in the analysis. Premorbid β-blocker exposure was defined as the prescription of any β-blocker for at least 1 month. Bisoprolol, metoprolol, and atenolol were classified as β1-selective β-blockers, and others were classified as nonselective β-blockers. All patients were followed for 28 days or until death.

Results
Among 1262 septic patients, 209 (16.6%) patients were long-term β-blocker users. Patients with premorbid β-blocker exposure had lower heart rates, initial lactate concentrations, and ICU mortality. After adjustment for disease severity, comorbidities, blood pressure, heart rate, and laboratory data, reduced ICU mortality was associated with premorbid β1-selective [adjusted hazard ratio, 0.40; 95% confidence interval (CI), 0.18–0.92; P = 0.030], but not non-selective β-blocker use.

Conclusion
Premorbid β1-selective, but not non-selective, β-blocker use was associated with improved mortality in septic patients. This finding supports the protective effect of β1-selective β-blockers in septic patients. Prospective studies are needed to confirm it.
Development, piloting, and evaluation of an evidence-based informed consent form for total knee arthroplasty (EvAb-Pilot): a protocol for a mixed methods study
Authors: Weise Alina , Lühnen Julia , Bühn Stefanie , Steffen Felicia , Zacher Sandro , Lauberger Julia , Ates Deha Murat , Böhmer Andreas , Rosenau Henning , Steckelberg Anke , Mathes Tim 
Published: May 2021

AbstractBackgroundPractitioners frequently use informed consent forms to support the physician-patient communication and the informed consent process. Informed consent for surgery often focuses on risk centered information due to high liability risks for treatment errors. This may affect patients’ anxiety of adverse events and the nocebo effect. This study focuses on the optimization of pre-surgical information on risks and complications, and at the same time reconciles these information with legal requirements.MethodsThe development, piloting, and evaluation of evidence-based informed consent forms for total knee arthroplasty (TKA) and related anesthesia procedures will follow the UK MRC Framework for developing and evaluating complex interventions. Conducting different sub-studies, we will (I) qualitatively explore the information acquisition and decision-making processes, (II) develop and pilot test evidence-based informed consent forms on the example of TKA and related anesthesia procedures, (III) conduct a monocentric interrupted time series (ITS) pilot study to evaluate the effects of evidence-based informed consent forms in comparison with standard consent forms, and (IV) perform a process evaluation to identify barriers and facilitators to the implementation of the intervention and to analyze mechanisms of impact.DiscussionThe evidence-based and understandable presentation of risks in informed consent forms aims at avoiding distorted risk depiction and strengthening the patients’ competencies to correctly assess the risks of undergoing surgery. This might reduce negative expectations and anxiety of adverse events, which in turn might reduce the nocebo effect. At the same time, the practitioners’ acceptance of evidence-based informed consent forms meeting legal requirements could be increased.Trial registrationClinicalTrials.gov,NCT04669483. Registered 15 December 2020.German Clinical Trials Registry,DRKS00022571. Registered 15 December 2020
Study of the probable genotoxic effects of Zolone (Phosalone) exposure in mice bone marrow derived cells
Authors: Khodabandeh Zohre , Etebari Mahmoud , Aliomrani Mehdi 
Published: May 2021

Abstract
Background and aim
Approximately, 2 million tonnes of pesticides are utilized annually worldwide. Phosalone (Pln), an organophosphorus pesticide, acts as an insecticide and acaricide to control pests of crops such as nuts, citrus fruits, pomegranates, stone fruits, grapes, potatoes, and artichokes. The purpose of this study was to evaluate the possible genotoxic effects following exposure to Pln in the cells derived from mouse red bone marrow.

Materials and methods
Sixty mice were divided into 6 groups including cyclophosphamide (40 mg/kg, IP) and Pln (6, 12, 20, and 40 mg/kg) exposure by gavage. After 1 and 5 days of exposure, animals were euthanized and the genotoxicity assays were done on bone marrow extracted cells.

Results
Comet assay shows a time and dose-dependent toxicity which further DNA degradation is observed after 5-day exposure (p < 0.05). Also, Pln significantly increased the MnPCE/PCE ratio after 12 and 20 mg/kg administration while no significant difference was reported between the doses of 6 and 40 mg/kg BW with the negative control group.

Conclusion
Our results suggested a serious concern about its potential effects on biological life and related disease inductions. However further studies need to confirm the exact mechanism of Pln genotoxicity and the cause of diverse response of its activity at 40 mg/kg. This study also showed that increasing the dose of Pln reduces the MnNCE/Total cells ratio, which may indicate the possibility of bone marrow suppression. All of the above results emphasize the need to seriously limit the use of this compound as an agricultural pesticide.
Biochemical profile, non-enzymatic antioxidants and functional attributes of raw and thermally processed West African Mud Creeper, Tympanotonos fuscatus var radula (Linnaeus, 1758)
Authors: Moruf Rasheed Olatunji 
Published: May 2021

AbstractBackgroundOne of the many relevant factors that influence mollusc consumption is the quality of its meat. The meat ofTympanotonos fuscatusvarradulahas been traditionally used as a subsistence food source with high-quality nutritious culinary delicacy. The study assessed the biochemical profile, non-enzymatic antioxidants and functional attributes ofT.fuscatusvarradulafrom a brackish Creek in Southwest Nigeria.ResultsProtein formed the highest percentage both in raw and steamed samples with the mean values of 47.61 g/100 g and 46.04 g/100 g respectively. The total mineral content was higher in raw sample (237.40 mg 100 g−1) than in steamed sample (201.05 mg 100 g−1), in the decreasing order of phosphorus > sodium > calcium > potassium > magnesium. Raw sample had the highest proportion of energy contribution, which was from protein (PEP = 53.1%), while the least energy contribution was from fat (PEF = 3.1%) in steamed sample. The cholesterol content of rawT. fuscatusvarradulawas 0.15 ± 0.01 mg/100 g, being reduced by steaming to 0.12 ± 0.02 mg/100 g, while a nonsignificantly lower percentage of oleic was also observed in steamed sample (0.98 ± 0.01%). After steaming, the values of TBA, ascorbic acid and DPPH increased from 0.22 to 1.41 mg/100 g, 15.31 to 20.54 mg/100 g and 65.11 to 84.6%, respectively. Relatively, higher mean values of water absorption capacity (198.13%), oil absorption capacity (292.59%), and foam capacity (6.90%) were recorded in raw sample, while steamed sample was better in foam stability (33.33%) and emulsion stability (51.51%).ConclusionsT. fuscatusvarradulais a good source of nutrition, rich in protein and because of its good functional physiognomies, the steamed edible part will be highly desirable for preparing complimentary food.
Peuyeum: fermented cassava from Bandung, West Java, Indonesia
Authors: Cempaka Laras 
Published: May 2021

AbstractPeuyeum is a fermented cassava product from Indonesia. Peuyeum or cassava tapay is known as “Peuyeum Bandung,” whose name refers to a provincial capital in West Java, Java Island. Peuyeum is processed through fermentation and uses starter cultures in the form of yeast tapay. The word peuyeum comes from “meuyeum” or “memeram,” which in Sundanese—the native language of West Java—means an incubation. This is because the process to make it requires curing time for ripening. The cassava is peeled, cleaned, and boiled to soften the tissue, then the starter is added and incubated for a certain time. The skill of making peuyeum is a generational one, passed down so that this traditional food is still preserved, even though it has become the local specialty of West Java. Derivative products are now increasingly diverse, which are fried tapay, colenak (grilled peuyeum served with a mixture of brown sugar and coconut shavings), mixed fruit ice, peuyeum cake, and others. In fact, for all the abovementioned cuisines, it can be said that fermentation was applied in producing the various traditional food items. Philosophically, peuyeum represents societies, group solidarity, peace of mind, and language symbolism. Thus, this paper discusses the history, philosophy, process, and derivative products of peuyeum.
Organizational supports for knowledge translation in paediatric health centres and research institutes: insights from a Canadian environmental scan
Authors: Glegg Stephanie Miranda Nadine , Ryce Andrea , Miller Kimberly J. , Nimmon Laura , Kothari Anita , Holsti Liisa 
Published: May 2021

Abstract
Background
Organizational supports are thought to help address wide-ranging barriers to evidence-informed health care (EIHC) and knowledge translation (KT). However, little is known about the nature of the resources and services that exist within paediatric health care and research settings across Canada to facilitate evidence use in health care delivery. This survey examined existing supports for EIHC/KT within these organizations to inform the design of similar EIHC/KT support programmes.

Methods
A national environmental scan was conducted using a bilingual online survey distributed to leaders at Canadian paediatric academic health science centres and their affiliated research institutes. Participants were invited through email, social media and webinar invitations and snowball sampling. Supports of interest included personnel, resources, services, organizational structures or processes, and partnerships or collaborations; barriers and successes were also probed. Data were compiled by site, reported using descriptive statistics, or grouped thematically. Supports were described using the AIMD (Aims, Ingredients, Mechanism, Delivery) framework.

Results
Thirty-one respondents from 17 sites across seven provinces represented a 49% site response rate. Eleven (65%) sites reported an on-site library with variable staffing and services. Ten (59%) sites reported a dedicated KT support unit or staff person. Supports ranged from education, resource development and consultation to protocol development, funded initiatives and collaborations. Organizations leveraged internal and external supports, with the majority also employing supports for clinical research integration. Supports perceived as most effective included personnel, targeted initiatives, leadership, interdepartmental expertise, external drivers and logistical support. Barriers included operational constraints, individual-level factors and lack of infrastructure.

Conclusions
This first survey of organizational supports for EIHC/KT identified the range of supports in place in paediatric research and health care organizations across Canada. The diversity of supports reported across sites may reflect differences in resource capacity and objectives. Similarities in EIHC/KT and research integration supports suggest common infrastructure may be feasible. Moreover, stakeholder engagement in research was common, but not pervasive. Tailored support programmes can target multi-faceted barriers. Findings can inform the development, refinement and evaluation of EIHC/KT support programmes and guide the study of the effectiveness and sustainability of these strategies.
Topological turbulence in spin-orbit–coupled driven-dissipative quantum fluids of light generates high-angular-momentum states
(a)
Authors: Koniakhin S. V. , Malpuech G. , Solnyshkov D. , Nalitov A. V. 
Published: May 2021

Abstract
We demonstrate the formation of a high-angular-momentum turbulent state in an exciton-polariton quantum fluid with TE-TM Spin-Orbit Coupling (SOC). The transfer of particles from quasi-resonantly cw pumped

component to

component is accompanied with the generation of a turbulent gas of quantum vortices by inhomogeneities. We show that this system is unstable with respect to the formation of bogolons at a finite wave vector, controlled by the laser detuning. This instability can be triggered by an inhomogeneity of the pumping profile as in present calculations or by other sources like natural disorder in the cavity. In a finite-size cavity, the domains with this wave vector form a ring-like structure along the border of the cavity, with a gas of mostly same-sign vortices in the center. The total angular momentum is imposed by the sign of TE-TM SOC, the wave vector at which the instability develops, and the cavity size. This effect can be detected experimentally via local dispersion measurements or by interference. The proposed configuration thus allows simultaneous experimental studies of quantum turbulence and high-angular-momentum states in continuously pumped exciton-polariton condensates.
Quantum dot in a hybrid structure with dipolar excitons
Authors: Mahmoodian M. M. , Chaplik A. V. 
Published: May 2021

Abstract
Electron states in a quantum dot (QD) located near a 2D system of dipolar excitons are perturbed by fluctuations of the exciton density caused by the electron-exciton interaction. This results in the frequency changes of electron transitions in a QD. The frequency depends on the exciton density, as well as on the exciton gas phase state. In the present work, the shifts of the two lowest QD energy levels are found both in the normal state of the exciton system and for the Bose-Einstein condensation (BEC) regime.