bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indigenous peoples’ positive experiences of culturally safe health care: a qualitative systematic review protocol
Authors: Harding Jillian , MacKinnon Karen , Sangster-Gormley Esther , Gordon Carol 
Published: March 2021

ABSTRACT

Objective:
The purpose of this systematic review is to explore what is known about Indigenous peoples’ positive experiences with culturally safe health care.

Introduction:
Research indicates that Indigenous people often experience stigma and discrimination from non-Indigenous health care providers when accessing health care services. One approach that has been put forward to address Indigenous health inequities is cultural safety. Studies have been conducted to identify what comprises culturally safe care for Indigenous people, however, many of these studies target the health care provider's perspective, rather than the perspective of the Indigenous person who is receiving the care.

Inclusion criteria:
This review will consider studies that involve Indigenous peoples’ positive experiences with culturally safe health care from any study setting. Studies that present relevant qualitative findings including descriptions, examples, or stories about how a health care provider enacted cultural safety from Indigenous perspectives will be considered.

Methods:
MEDLINE, CINAHL, Embase, PsycINFO, First Nations Periodical Index, the Native Health Database, the Indigenous Studies Portal, and the Arctic and Antarctic Regions Database will be searched for published studies. The search for unpublished studies will include Google and Google Scholar, ProQuest Dissertations and Theses, and OpenGrey. Databases will be searched from 1988 onward and only studies published in English will be included. The JBI systematic review guidelines will be followed. The JBI process of meta-aggregation will be used to identify categories and synthesize findings. The ConQual approach will be used to assess confidence in the review findings.

Systematic review registration number:
PROSPERO CRD42020173003
Strategies for measuring prescription medication switching with pharmacy claims data: a scoping review protocol
Authors: Harris Daniel A. , Bouck Zachary , Tricco Andrea C. , Cadarette Suzanne M. , Iaboni Andrea , Bronskill Susan E. 
Published: March 2021

ABSTRACT

Objective:
This scoping review will aim to compare strategies for measuring prescription medication switching with pharmacy claims data, with a focus on psychotropic vs non-psychotropic medications.

Introduction:
Medication switching (ie, the replacement of one medication for another) is common and occurs due to several factors (such as adverse effects to a specific medication). In pharmacoepidemiology studies that use pharmacy claims data, it is important to identify and account for switches; however, due to data limitations and lack of a methodological standard, this can be challenging. The aim of this scoping review is to describe how studies have previously measured medication switching with pharmacy claims data in order to create a repository of common strategies and highlight areas for future research.

Inclusion criteria:
This review will include studies that have used pharmacy claims data to measure medication switching as their primary independent or dependent variable. Studies conducted at the individual level (ie, not ecological), published between January 1, 1980, and October 31, 2020, and investigating orally administered, non-anti-infective medications will be considered. No age, population, or context restrictions are specified as inclusion criteria.

Methods:
JBI methodology and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews were used for this protocol. MEDLINE (PubMed), Embase (Ovid), Central (Cochrane Library), CINAHL (EBSCO), and Google Scholar will be searched with the assistance of a health sciences research librarian. Two reviewers will independently screen titles, abstracts, and full-text articles. Strategies for measuring medication switching will be narratively described and summarized overall and by broad medication class.
A Robust Impedance Controller for Improved Safety in Human–Robot Interaction
Authors: Laubscher Curt A. , Sawicki Jerzy T. 
Published: March 2021

Abstract
This paper presents a novel impedance controller modified with a switching strategy for the purpose of improving safety in human–robot interactions. Under normal operating conditions, an impedance controller is enabled when adequate tracking performance is maintained in the presence of bounded disturbances. However, if disturbances are greater than anticipated such that tracking performance is degraded, the proposed controller temporarily switches modes to a control strategy better apt to limit control inputs. With disturbances returning to the prescribed bounds, tracking performance will be restored and the impedance controller will resume for nominal operation. The control parameters are constrained by a few conditions necessary for smooth operation. First, a pair of equality constraints is required for the control signal to be continuous when switching control modes. Second, a Lyapunov analysis is performed to formulate an equality constraint on the control parameters to ensure only a single switch occurs when changing control modes to avert control chatter. Third, a matrix inequality constraint is necessary to ensure a robust positive invariant set is formed for when impedance control is active. Numerical simulations are provided to illustrate the controller and conditions. The simulation results successfully validate the presented theory, demonstrating how the constraints yield a continuous control signal, eliminate switching chatter, and permit robustness to disturbances.
Leader-Following Consensus Over Acyclic Switching Digraphs
Authors: He Changran , Huang Jie 
Published: March 2021

Abstract
The existing results on the leader-following consensus problem for linear continuous-time multi-agent systems over jointly connected switching digraphs rely on the assumption that the system matrices do not have eigenvalues with positive real parts. In this paper, to remove this assumption, we first establish a stability result for a class of linear switched systems. Then, we show that the leader-following consensus problem for linear multi-agent systems with general system modes over jointly connected switching digraphs is solvable if the digraphs are acyclic. Moreover, the leader-following consensus can be achieved at a pre-assigned but arbitrarily fast convergence rate. A numerical example is provided to illustrate our design.
Pleasant Emotions Widen Thought–Action Repertoires, Develop Long-Term Resources, and Improve Reaction Time Performance: A Multistudy Examination of the Broaden-and-Build Theory Among Athletes
Authors: Thompson Mark A. , Nicholls Adam R. , Toner John , Perry John L. , Burke Rachel 
Published: March 2021

The authors investigated relationships between emotions, coping, and resilience across two studies. In Study 1a, 319 athletes completed dispositional questionnaires relating to the aforementioned constructs. In Study 1b, 126 athletes from Study 1a repeated the same questionnaires 6 months later. In Study 2, 21 athletes were randomly allocated to an emotional (e.g., pleasant or unpleasant emotions) or control group and undertook a laboratory-based reaction-time task across three time points. Questionnaires and salivary cortisol samples were collected before and after each performance with imagery-based emotional manipulations engendered during the second testing session. Partial longitudinal evidence of the broaden-and-build effects of pleasant emotions was found. Pleasant emotions may undo lingering cognitive resource losses incurred from previous unpleasant emotional experiences. In Study 2, pleasant and unpleasant emotions had an immediate and sustained psychophysiological and performance impact. Taken together, this research supports the application of broaden-and-build theory in framing emotional interventions for athletes.
Temperatures of Late Cretaceous (Campanian) methane-derived authigenic carbonates from the Western Interior Seaway, South Dakota, USA, using clumped isotopes
Authors: Gao Yang , Henkes Gregory A. , Cochran J. Kirk , Landman Neil H. 
Published: March 2021

Abstract
Methane seep deposits, comprising large, carbonate-rich mounds formed from hydrocarbon seepage, were widely distributed in the Late Cretaceous Western Interior Seaway (WIS) of North America. Well-preserved, methane-derived authigenic carbonates (MDACs) from these deposits have been shown to retain petrological, paleontological, and geochemical imprints of their ancient depositional setting, all of which are important for understanding the dynamics and evolution of the shallow, epeiric WIS. To better characterize the environmental conditions of WIS seeps, we applied clumped isotope paleothermometry to magnesium calcite MDAC samples from five seep localities in the upper Campanian Pierre Shale, South Dakota, USA. We measured 21 subsamples, including 18 micritic carbonates and demonstrated apparent clumped isotope equilibrium between MDACs and WIS bottom waters. Extreme 13C depletion in most samples (δ13C ranging to −45.44‰) indicates they were precipitated with oxidized methane as a major source of dissolved inorganic carbon, which itself implies a close association with ancient methanotrophic metabolism. The average clumped isotope paleotemperature from the micritic carbonates is 23 ± 7 °C (1σ standard deviation), which agrees with bottom water paleotemperatures inferred from δ18O measurements of MDACs and well-preserved mollusk shells at similar localities in the WIS. The calculated average δ18Ow value for these samples is −0.5 ± 1.7‰ (1σ SD), which is indistinguishable from previously reported calculation on Campanian seawater δ18Ow from fossil mollusk shells, but elevated above younger fossils collected from other locations in the WIS. Our conclusions are inconsistent with previously hypothesized disequilibrium for WIS MDAC clumped isotope and therefore we propose that fossil MDAC deposits may be used as paleotemperature archives.
Microbial Arsenal of Antiviral Defenses – Part I
Authors: Isaev Artem B. , Musharova Olga S. , Severinov Konstantin V. 
Published: March 2021

Abstract
Bacteriophages or phages are viruses that infect bacterial cells (for the scope of this review we will also consider viruses that infect Archaea). Constant threat of phage infection is a major force that shapes evolution of the microbial genomes. To withstand infection, bacteria had evolved numerous strategies to avoid recognition by phages or to directly interfere with phage propagation inside the cell. Classical molecular biology and genetic engineering have been deeply intertwined with the study of phages and host defenses. Nowadays, owing to the rise of phage therapy, broad application of CRISPR-Cas technologies, and development of bioinformatics approaches that facilitate discovery of new systems, phage biology experiences a revival. This review describes variety of strategies employed by microbes to counter phage infection, with a focus on novel systems discovered in recent years. First chapter covers defense associated with cell surface, role of small molecules, and innate immunity systems relying on DNA modification.
Small and sick newborn care during the COVID-19 pandemic: global survey and thematic analysis of healthcare providers’ voices and experiences
Authors: Rao Suman P N , Minckas Nicole , Medvedev Melissa M , Gathara David , Y N Prashantha , Seifu Estifanos Abiy , Silitonga Alfrida Camelia , Jadaun Arun Singh , Adejuyigbe Ebunoluwa A , Brotherton Helen , Arya Sugandha , Gera Rani , Ezeaka Chinyere V , Gai Abdou , Gobezayehu Abebe Gebremariam , Dube Queen , Kumar Aarti , Naburi Helga , Chiume Msandeni , Tumukunde Victor , Medhanyie Araya Abrha , Plange-Rhule Gyikua , Shabini Josephine , Ohuma Eric O , Tadele Henok , W/Gebriel Fitsum , Hadgu Amanuel , Alamineh Lamesgin , Mehta Rajesh , Molyneux Elizabeth , Lawn Joy E 
Published: March 2021

IntroductionThe COVID-19 pandemic is disrupting health systems globally. Maternity care disruptions have been surveyed, but not those related to vulnerable small newborns. We aimed to survey reported disruptions to small and sick newborn care worldwide and undertake thematic analysis of healthcare providers’ experiences and proposed mitigation strategies.MethodsUsing a widely disseminated online survey in three languages, we reached out to neonatal healthcare providers. We collected data on COVID-19 preparedness, effects on health personnel and on newborn care services, including kangaroo mother care (KMC), as well as disruptors and solutions.ResultsWe analysed 1120 responses from 62 countries, mainly low and middle-income countries (LMICs). Preparedness for COVID-19 was suboptimal in terms of guidelines and availability of personal protective equipment. One-third reported routine testing of all pregnant women, but 13% had no testing capacity at all. More than 85% of health personnel feared for their own health and 89% had increased stress. Newborn care practices were disrupted both due to reduced care-seeking and a compromised workforce. More than half reported that evidence-based interventions such as KMC were discontinued or discouraged. Separation of the mother–baby dyad was reported for both COVID-positive mothers (50%) and those with unknown status (16%). Follow-up care was disrupted primarily due to families’ fear of visiting hospitals (~73%).ConclusionNewborn care providers are stressed and there is lack clarity and guidelines regarding care of small newborns during the pandemic. There is an urgent need to protect life-saving interventions, such as KMC, threatened by the pandemic, and to be ready to recover and build back better.
Significant amelioration of hepatitis C virus infection in a hyperendemic area: longitudinal evidence from the COMPACT Study in Taiwan
Authors: Tsai Pei-Chien , Huang Ching-I , Yeh Ming-Lun , Huang Chung-Feng , Hsieh Meng-Hsuan , Yang Jeng-Fu , Hsu Po-Yao , Liang Po-Cheng , Lin Yi-Hung , Jang Tyng Yuan , Hsieh Ming-Yen , Dai Chia-Yen , Lin Zu-Yau , Chen Shinn-Chern , Huang Jee-Fu , Yu Ming-Lung , Chuang Wan-Long , Chang Wen-Yu 
Published: March 2021

ObjectivesHepatitis C virus (HCV) infection is the leading cause of cirrhosis and hepatocellular carcinoma worldwide. Tzukuan, located in the southwestern area of Taiwan, is an HCV hyperendemic area (>30%). This study aimed to assess the changing epidemiological characteristics of HCV infection and to evaluate the long-term outcomes after the implementation of public health strategies for two decades.DesignA population-based retrospective cohort study.SettingA comprehensive care programme was implemented, namely COMPACT Study, in Tzukuan since 1997.ParticipantsA total of 10 714 residents participated the screening.Outcome measuresThe HCV status, demographic and clinical profiles of the participants were recorded and validated annually from 2000 through 2019.ResultsThe HCV infection prevalence rates were 21.1% (1076/5099) in 2000–2004, 18.8% (239/1269) in 2005–2009, 14.1% (292/2071) in 2010–2014 and 10.3% (234/2275) in 2015–2019 (p for trend test <0.0001). Among them, 1614 underwent repeated tests during the follow-up period. The annual incidence rates were 0.54% in 2005–2009, 0.4% in 2010–2014 and 0.22% in 2015–2019, respectively (p=0.01). In addition to old age, lower education level was a major risk factor for HCV infection across different periods. HCV infection prevalence rate among those illiterates reached 40.9%, followed by 28.5% in those with elementary school level, and <10% in those with high school or higher levels. The major risk factor has shifted from iatrogenic exposure in 2000–2009 to household transmission after 2010.ConclusionsHCV infection has been decreasing and the epidemiological features are changing in the hyperendemic area by continuing education, prevention and treatment strategies.
Bugs and Brains, the Gut and Mental Health Study: a mixed-methods study investigating microbiota composition and function in anxiety, depression and irritable bowel syndrome
Authors: Simpson Carra A , Schwartz Orli S , Eliby Djamila , Butler Catherine A , Huang Katherine , O"Brien-Simpson Neil , Callaghan Bridget L , Dashper Stuart G , Gooley Paul R , Whittle Sarah , Haslam Nick , Simmons Julian G 
Published: March 2021

IntroductionResearch has highlighted relationships between the micro-organisms that inhabit our gastrointestinal tract (oral and gut microbiota) with host mood and gastrointestinal functioning. Mental health disorders and functional gastrointestinal disorders co-occur at high rates, although the mechanisms underlying these associations remain unclear. The Bugs and Brains Study aims to investigate complex relationships between anxiety/depression and irritable bowel syndrome (IBS) in two ways. First, its primary component will compare the gut and oral microbiota in females with anxiety/depression and/or IBS relative to controls, and investigate underlying physiological, endocrine and immune factors, as well as associations with diet and psychosocial factors. In an ancillary component, the study will also investigate gastrointestinal and mental health symptoms in a larger sample, and explore relationships with diet, exercise, oral health, substance use, medical history, early life adversity and psychosocial factors.Methods and analysisThe Bugs and Brains Study aims to recruit 160 females to the primary component: (1) 40 controls; (2) 40 participants with a depressive/anxiety disorder, but no IBS; (3) 40 participants with IBS, but no depressive/anxiety disorder and (4) 40 participants with both depressive/anxiety disorder and IBS. Participation is completed within 1 month, and involves comprehensive questionnaires, anthropometrics, a diagnostic clinical interview, collection of two saliva samples, and stool, urine and hair samples. This study aims to use a systems biology approach to characterise oral and gut microbial compositionandfunction using 16S rRNA gene sequencing and nuclear MR spectroscopy. As part of the ancillary component, it will collect questionnaire data from 1000 participants aged 18–40 years, capturing mental health, gastrointestinal health, oral health, diet and psychosocial factors.Ethics and disseminationApproval was granted by the University of Melbourne Human Research Ethics Committee (#1749221). All participants voluntarily provided informed consent. Results will be published in peer-reviewed journals and presented at scientific conferences.
Public and patient involvement in health data governance (DATAGov): protocol of a people-centred, mixed-methods study on data use and sharing for rare diseases care and research
Authors: de Freitas Cláudia , Amorim Mariana , Machado Helena , Leão Teles Elisa , Baptista Maria João , Renedo Alicia , Provoost Veerle , Silva Susana 
Published: March 2021

IntroductionInternational policy imperatives for the public and patient involvement in the governance of health data coexist with conflicting cross-border policies on data sharing. This can challenge the planning and implementation of participatory data governance in healthcare services locally. Engaging with local stakeholders and understanding how their needs, values and preferences for governing health data can be articulated with policies made at the supranational level is crucial. This paper describes a protocol for a project that aims to coproduce a people-centred model for involving patients and the public in decision-making processes about the use and sharing of health data for rare diseases care and research.Methods and analysisThis multidisciplinary project draws on an explanatory sequential mixed-methods study. A hospital-based survey with patients, informal carers, health professionals and technical staff recruited at two reference centres for rare diseases in Portugal will be conducted first. The qualitative study will follow consisting of semi-structured interviews and scenario-based workshops with a subsample of the participant groups recruited at baseline. Quantitative data will be analysed using descriptive and inferential statistics. Inductive and deductive approaches will be combined to analyse the qualitative interviews. Data from scenario-based workshops will be iteratively compared using the constant comparison method to identify cross-cutting themes and categories.Ethics and disseminationThe Ethics Committee for Health from the University Hospital Centre São João/Faculty of Medicine of University of Porto approved the study protocol (Ref. 99/19). Research findings will be disseminated at academic conferences and science promotion events, and through public meetings involving patient representatives, practitioners, policy-makers and students, a project website and peer-reviewed journal publications.
Double-blind, placebo-controlled randomised clinical trial to evaluate the effect of ASPIRIN discontinuation after left atrial appendage occlusion in atrial fibrillation: protocol of the ASPIRIN LAAO trial
Authors: Chen Mu , Wang Qunshan , Sun Jian , Zhang Peng-Pai , Li Wei , Mo Bin-Feng , Chen Tai-Zhong , Tang Xiaoli , Li Yi-Gang 
Published: March 2021

IntroductionIt is the common clinical practice to prescribe indefinite aspirin for patients with non-valvular atrial fibrillation (NVAF) post left atrial appendage occlusion (LAAO). However, aspirin as a primary prevention strategy for cardiovascular diseases has recently been challenged due to increased risk of bleeding. Therefore, aspirin discontinuation after LAAO in atrial fibrillation (ASPIRIN LAAO) trial is designed to assess the uncertainty about the risks and benefits of discontinuing aspirin therapy at 6 months postimplantation with a Watchman LAAO device in NVAF patients.Methods and analysisThe ASPIRIN LAAO study is a prospective, multicentre, randomised, double-blinded, placebo-controlled non-inferiority trial. Patients implanted with a Watchman device within 6 months prior to enrollment and without pre-existing conditions requiring long-term aspirin therapy according to current guidelines are eligible for participating the trial. Subjects will be randomised in a 1:1 allocation ratio to either the Aspirin group (aspirin 100 mg/day) or the control group (placebo) at 6 months postimplantation. A total of 1120 subjects will be enrolled from 12 investigational sites in China. The primary composite endpoint is stroke, systemic embolism, cardiovascular/unexplained death, major bleeding, acute coronary syndrome and coronary or periphery artery disease requiring revascularisation at 24 months. Follow-up visits are scheduled at 6 and 12 months and then every 12 months until 24 months after the last patient recruitment.Ethics and disseminationEthics approval was obtained from the Ethics Committee of Xinhua Hospital, Shanghai, China (reference number XHEC-C-2018-065-5). The protocol is also submitted and approved by the institutional Ethics Committee at each participating centre. Results are expected in 2024 and will be disseminated through peer-reviewed journals and presentations at national and international conferences.Trial registration numberNCT03821883.