bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rituximab and Dupilumab Improve Eosinophilic Granulomatosis With Polyangiitis With Multiple Pulmonary Thrombi
Authors: Adachi Sei , Oshikata Chiyako , Kaneko Takeshi , Tsurikisawa Naomi 
Published: September 2021

Abstract
BackgroundEosinophilic granulomatosis with polyangiitis (EGPA) is characterized by a necrotizing vasculitis with tissue and peripheral blood eosinophilia affecting small and medium-sized arteries, capillaries, and veins. Venous thromboembolic events have occurred in 19 of 232 (8.2%) patients with EGPA. However, there are only a few reported cases of EGPA complicated by pulmonary embolism or infarction. Case presentationWe report the case of a 43-year-old woman with eosinophilic granulomatosis with polyangiitis patient with acute respiratory and heart failure due to bilateral pulmonary artery thrombosis and left femoral vein thrombosis in addition to cardiac involvement as myocarditis, pericardial effusion, and diastolic dysfunction, gastrointestinal symptoms and peripheral neuropathy 12 years after disease onset. The condition was refractory to treatment with systemic corticosteroids, intravenous cyclophosphamide, and mepolizumab, but the acute cardiac failure associated with the thrombosis, cardiac and gastrointestinal symptoms, and multiple polyneuropathy improved after a switch to rituximab. But her heart failure did not improve sufficiently, she continued to need oxygen inhalation at 1 L/min and asthma exacerbations occurred. We changed the patient’s treatment with mepolizumab to dupilumab. Not only did she have no asthma attacks after switching to dupilumab, but also her vasculitis symptoms improved. Oxygen therapy was discontinued as heart failure improved five months after starting the dupilumab. ConclusionsThis may be the first case report of the successful treatment of pulmonary thromboembolism associated with EGPA by rituximab. In addition, in this patient, treatment with dupilumab was effective not only for the asthma symptoms but also for the symptoms of vasculitis.
Effective Adsorptive Removal of Methylene Blue from Water Using Wood- Plastic Composite Containing High Density Polyethylene and Wood Particles
Authors: Ranjbarha Zahra , Aliabad Javad Mokhtari , Aberoomand-Azar Parviz , Mirmohammadi Seyed Amin , Saber-Tehrani Mohammad 
Published: September 2021

Abstract
In this study, the ability to remove methylene blue cation pigment using wood-plastic composite containing high density polyethylene and wood powder as a recycled material was studied. The effect of some important parameters such as pH, adsorbent amount and contact time were investigated. Adsorption efficiencies for methylene blue was maximized at alkaline pH. Adsorption capacity increased with increasing adsorbent amount and contact time. The value of R2 in Langmuir model was equal to 1 and the separation factor for 0.5 and 1 g of adsorbent were 0.09 and 0.1, respectively. Given that the methylene blue adsorption data were more consistent with the Langmuir isotherm model, it can be stated that the wood-plastic composite probably has uniform adsorption surfaces and the adsorption process occurred in homogeneous system on the adsorbent surface. Based on the results of this study, it was observed that this composite is a suitable adsorbent for removing methylene blue from aqueous solutions and used as a purifying agent in the decolorization of effluents containing pigments. This adsorbent is recyclable and is cost-effective to remove dye from textile industry wastewater.
Adaptive Backstepping Nonsingular Terminal Sliding Mode Control of Servo System Based on New Sliding Mode and Reaching Law
Authors: zhu Qixin , Wang Jiaqi , Zhu Yonghong 
Published: September 2021

Abstract
Aiming at the problem that the control accuracy of permanent magnet synchronous motor (PMSM) servo system is easily affected by parameter uncertainty, an adaptive backstepping nonlinear nonsingular terminal sliding mode control (ABNNTSMC) method is proposed in this paper. Based on the existing fast nonsingular terminal sliding mode, a new piecewise nonlinear nonsingular terminal sliding mode is proposed to improve the convergence speed and ensure the steady-state accuracy. At the same time, a new reaching law with attenuation term is proposed to reduce the vibration gradually. Finally, the adaptive law is used to estimate the moment of inertia and viscous friction coefficient of the system to improve the robustness of the system. Simulation results show that ABNNTSMC has higher steady-state accuracy and smaller vibration compared with several existing results.
Liquid Droplet Impact on a Sonically Excited Thin Membrane
Authors: Abubakar Abba , Yilbas Bekir , Al-Qahtani Hussain , Alzaydi Ammar 
Published: September 2021

Abstract
Impacting droplet characteristics on hydrophobic surfaces can be altered by introducing surface oscillations. Impacting water droplet contact duration, spreading, retraction, and rebounding behaviors are examined at various sonic excitation frequencies of the hydrophobic membrane. Membrane oscillation and droplet behavior are analyzed by utilizing a high-speed camera. The restitution coefficient and membrane dynamics are formulated and the findings are compared with those of the experiments. It is found that the mode of membrane oscillation changes as the sonic excitation frequency is changed. The droplet spreading and retraction rates reduce while rebound height and restitution coefficient increase at a sonic excitation frequency of 75 Hz. However, further increase of the excitation frequency results in reduced rebound height because of increased energy dissipation on the impacted surface. The droplet contact (transition time) duration reduces as the excitation frequency increases. Increasing droplet Weber number enhances the droplet contact period on the membrane, which becomes more apparent at low frequencies of sonic excitation.
Optimal State Space Reconstruction via Monte Carlo Decision Tree Search
Authors: Kraemer Kai Hauke , Gelbrecht Maximilian , Pavithran Induja , Sujith R.I. , Marwan Norbert 
Published: September 2021

Abstract
A novel idea for an optimal time delay state space reconstruction from uni- and multivariate time series is presented. The entire embedding process is considered as a game, in which each move corresponds to an embedding cycle and is subject to an evaluation through an objective function. This way the embedding procedure can be modeled as a tree, in which each leaf holds a specific value of the objective function. By using a Monte Carlo ansatz the proposed algorithm populates the tree with many leafs by computing different possible embedding paths and the final embedding is chosen as that particular path, which ends at the leaf with the lowest achieved value of the objective function. The method aims to prevent getting stuck in a local minimum of the objective function and can be used in a modular way, enabling practitioners to choose a statistic for possible delays in each embedding cycle as well as a suitable objective function themselves. As a proof of concept, we demonstrate the superiority of the proposed method over the classical time delay embedding methods using a variety of application examples. We compare recurrence plot based statistics inferred from reconstructions of a Lorenz-96 system and highlight an improved forecast accuracy for map-like model data as well as for paleoclimate isotope time series. Finally we utilize state space reconstruction for the detection of causality and its strength between observables of a gas turbine type thermoacoustic combustor.
Comparative Performance of the Genolab M and Novaseq 6000 Sequencing Platforms for Transcriptome and LncRNA Analysis
Authors: Liu Yongfeng , Han Ran , Zhou Letian , Luo Mingjie , Zeng Lidong , Zhao Xiaochao , Ma Yukun , Zhou Zhiliang , Sun Lei 
Published: September 2021

Abstract
Background: GenoLab M is a recently established next-generation sequencing platform from GeneMind Biosciences. Presently, Illumina sequencers are the globally leading sequencing platform in the next-generation sequencing market. Here, we present the first report to compare the transcriptome and LncRNA sequencing data of the GenoLab M sequencer to NovaSeq 6000 platform in various types of analysis.Results: We tested 16 libraries in three species using various library kits from different companies. We compared the data quality, genes expression, alternatively spliced (AS) events, single nucleotide polymorphism (SNP), and insertions–deletions (InDel) between two sequencing platforms. The data suggested that platforms have comparable sensitivity and accuracy in terms of quantification of gene expression levels with technical compatibility. Conclusions: Genolab M is a promising sequencing platform for transcriptomics and LncRNA studies with high performance at low costs.
The Impact of Socioeconomic Status on Staging, Prognosis in Hepatocellular Carcinoma
Authors: Zhou Yongjie , Zhang Wen , Ma Jingqin , Zhang Zihan , Yang Minjie , Luo Jianjun , Yan Zhiping 
Published: September 2021

Abstract
Purpose: We conducted this large population-based study to evaluate the impact of socioeconomic status (SES) factors on cancer-specific survival (CSS) of patients with hepatocellular carcinoma (HCC). We further assessed the predictive value of a novel TNM-SES staging system which incorporated these SES factors with TNM stage.Methods: A total of 13791 patient diagnosed with HCC from 2012-2016 were retrieved from the large population database. Cox proportional hazards regression model and Harrell's concordance index (C-index) was used to identify the SES factors associated with CSS and analyze the prognostic value of TNM-SES stage. Kaplan–Meier curves and log-rank test were performed to evaluate CSS.Results: Four SES factors (marital status, insurance status, education, household income) were identified as the prognostic predictor associated with CSS. The SES-2 (lower SES) stage was significantly correlated to unfavorable CSS of the patients with HCC, with a 32.0% increased risk (HR = 1.32, 95% CI (1.26 - 1.39), P<0.001), after adjusting for several confounders. The C-index of the TNM-SES stage was 0.735(95% CI (0.729 - 0.741)) which was higher than that of the TNM stage (0.718, 95%CI (0.712 - 0.724)), indicating a high accuracy of prognostic prediction.Conclusion: Our comprehensive study revealed that SES was significantly associated with prognosis of patient with HCC after adjusting several confounders. The novel TNM-SES staging system which combined TNM stage and SES stage had more superior predictive value than traditional TNM stage. Disparity on SES should receive more attention for patients with HCC in clinical management.
The Responses of Soil Mineral-associated Organic Carbon to Exogenous Carbon Additions: a Protocol for a Systematic Review and Meta-analysis
Authors: Zhang Futao , Ye Yang , Zhang Bin 
Published: September 2021

Abstract
Background: Increased exogenous carbon inputs into soils under global climate change can induce soil organic carbon (SOC) decomposition, which has profound effects on carbon cycle and feedback on climate change. Soil mineral-associated organic carbon (MAOC) is the SOC protected from decomposition through association with minerals. Recent studies demonstrated that MAOC can be mineralized due to exogenous carbon inputs. The objective of this study is to provide the methods used to explore the effect of exogenous carbon inputs on MAOC and the controlling factors.Methods: We will search for the potential studies that evaluating the influence of carbon additions on MAOC content and decomposition through the Web of Science, Scopus and China National Knowledge Infrastructure until August 2021. If the studies searched by using keywords meet the inclusion criteria, then they were included. The STATA software (version 15.0) will be used to perform data analysis. The results include the content and decomposition intensity of MAOC induced by exogenous carbon additions and the controlling factors. Study selection, data extraction, and assessment of bias risk will be conducted by two reviewers independently. Subgroup analysis will be carried out to explore sources of heterogeneity when heterogeneity is observed. Sensitivity analysis will be used to assess the robustness of the analyses.Discussion: This study will provide useful methods for exploring the effect of carbon additions on MAOC and the controlling factors.
Evaluating Methodological Quality of Prognostic Prediction Models on Patient Reported Outcome Measurements after Total Hip Replacement and Total Knee Replacement Surgery: a systematic review protocol
Authors: Chang Wei-Ju , Naylor Justine , Natarajan Pragadesh , Menounos Spiro , Monuja Masiath , Adie Sam 
Published: September 2021

Abstract
Background

Prediction models for poor patient-reported surgical outcomes after total hip replacement (THR) and total knee replacement (TKR) may provide a method for improving appropriate surgical care for hip and knee osteoarthritis. There are concerns about methodological issues and the risk of bias of studies producing prediction models. A critical evaluation of the methodological quality of prediction modelling studies in THR and TKR is needed to ensure their clinical usefulness. This systematic review aims to: 1) evaluate and report the quality of risk stratification and prediction modelling studies that predict patient-reported outcomes after THR and TKR; 2) identify areas of methodological deficit and provide recommendations for future research; and 3) synthesise the evidence on prediction models associated with post-operative patient-reported outcomes after THR and TKR surgeries.
Methods

MEDLINE, EMBASE and CINAHL electronic databases will be searched to identify relevant studies. Title and abstract and full-text screening will be performed by two independent reviewers. We will include: 1) prediction model development studies without external validation; 2) prediction model development studies with external validation of independent data; 3) external model validation studies; and 4) studies updating a previously developed prediction model. Data extraction spreadsheets will be developed based on the CHARMS checklist and TRIPOD statement and piloted on two relevant studies. Study quality and risk of bias will be assessed using the PROBAST tool. Prediction models will be summarised qualitatively. Meta-analyses on the predictive performance of included models will be conducted if appropriate.
Discussion

This systematic review will evaluate the methodological quality and usefulness of prediction models for poor outcomes after THR or TKR. This information is essential to provide evidence-based healthcare for end-stage hip and knee osteoarthritis. Findings of this review will contribute to the identification of key areas for improvement in conducting prognostic research in this field and facilitate the progress in evidence-based tailored treatments for hip and knee osteoarthritis.
Systematic review registration:
Submitted to PROSPERO on 30 August 2021.
Abundance of colistin-resistant Escherichia coli harbouring mcr-1 and extended-spectrum β-lactamase-producing E. coli co-harbouring blaCTX-M-55 or -65 with blaTEM isolates from chicken meat in Vietnam
Authors: Nakayama Tatsuya , Hien Le Thi , Phong Ngo Thanh , Tran Doan Nguyen Minh , Nguyen Oanh Thi Hoang , Phuong Hoang Hoai , Yamaguchi Takahiro , Jinnai Michio , Nguyen Phuc Do , Dang Chinh Van , Kumeda Yuko , Hase Atsushi 
Published: September 2021

Abstract
Although the spread of plasmid-mediated antibiotic-resistant bacteria is a public health concern, food contamination with plasmid-mediated antibiotic-resistant Escherichia coli has not been well investigated in Vietnam. The aim of this study was to describe the prevalence of colistin-resistant, carbapenem-resistant and endemic blaCTX−M in extended-spectrum β-lactamase (ESBL)-producing E. coli isolates. Colistin- and carbapenem-resistant ESBL-producing E. coli were isolated from chickens in Vietnam and Japan. The results showed that 52% and 93% of Vietnamese chicken was isolated with colistin-resistant and AmpC/ESBL-producing E. coli, respectively, while 52.7% of Japanese chickens were isolated with AmpC/ESBL-producing E. coli. Carbapenem-resistant E. coli has not been isolated in Vietnam or Japan. Genotyping revealed that colistin-resistant E. coli harboured mcr-1, and most of the AmpC/ESBL-related genes were blaCTX−M−55 and blaCTX−M−65 together with blaTEM in Vietnamese chickens, and blaCMY−2 in Japanese chickens. Multidrug resistance analysis showed that ESBL-producing E. coli isolates were more resistant to quinolones, streptomycin, and chloramphenicol compared with colistin-resistant E. coli isolates from Vietnam, suggesting selection in ESBL-producing E. coli for multiple antibiotic resistance genes. In conclusion, colistin-resistant E. coli was detected in about half of the chicken meat samples, the majority of which were found to harbour mcr-1. The high prevalence of ESBL-producing E. coli has remained constant across the last five years, and the predominant blaCTX−M for ESBL-producing E. coli was found to be blaCTX−M−55 or blaCTX−M−65, with the coexistence of blaTEM in Vietnam. Our results can be implemented in monitoring systems to combat the development of antimicrobial resistance.
Environmental characteristics and changes of bacterial communities in the meltwater runoff of glacier in Ny-Alesund, Arctic
Authors: Lin Lidong , Wang Nengfei , Han Wenbing , Zhang Botao , Zang Jiaye , Li Qinxin , Qin Yiling , Wang Long , Zhang Fang , Liu Jie 
Published: September 2021

Abstract
The present study assessed the diversity and composition of bacterial communities in glacial runoff and glacial soils in the Midre Lovénbreen glacier region of Svalbard. A total of 6,593 operational taxonomic units were identified by high-throughput sequencing. The results showed differences in bacterial community composition between the upper and lower reaches of glacial runoff. The abundance of Actinobacteria, Firmicutes, Betaproteobacteria and Gammaproteobacteria in the upper reaches of glacial runoff was higher than that in the lower reaches. In contrast, the the abundance of Cyanobacteria and Alphaproteobacteria in the downstream of glacial runoff was higher than that in the upstream. In addition, we compared bacterial diversity and composition between glacial runoff areas and soils. The chart analysis showed that bacterial diversity in glacial soil was higher than that in the glacial runoff. Some typical bacteria in the soil, such as Actinobacteria, entered glacial runoff through contact between them. The abundance of Acidobacteria, Sphingobacterium and Flavobacterium was higher in glacial soil. Weighted correlation network analysis showed that the core bacteria in glacial runoff and glacial soil were typical bacteria in different habitats. Distance-based redundancy analysis revealed that NO 2 - -N was the most significant factor affecting the distribution of soil bacterial community, while NO 3 - -N was the most significant factor affecting the distribution of glacial runoff bacterial community.
Stoma location and Parastomal Hernia. A Virtual Simulation Approach.
Authors: Tuset Lluís , López-Cano Manuel , Fortuny Gerard , López Josep M. , Herrero Joan , Puigjaner Dolors 
Published: September 2021

Abstract
An ostomy is a surgical procedure by which an artificial opening in the abdominal wall, known as a stoma, is created. We assessthe effects of stoma location on the abdominal wall mechanics. We perform three–dimensional finite element simulations on ananatomy model which was generated on the basis of medical images. Our simulation methodology is entirely based on opensource software. We consider seventeen different locations for the stoma incision (trephine) and we simulate the mechanicalresponse of the abdominal wall when an intraabdominal pressure as high as 20 kPa is applied. We focus on factors relatedto the risk of parastomal hernia development such as the deformation experienced by the abdominal wall, the stress levelssupported by its tissues and the corresponding level of trephine enlargement.No significant dependence was found between stoma location and the levels of abdominal wall deformations or stress supportedby tissues, except for the case with a stoma located on the linea alba. Trephine perimeter and area respectively increased byas much as 44% and 85%. The level of trephine deformation depends on stoma location with considerably higher trephineenlargements found in stomas laterally located with respect to the rectus abdominis muscle.
Repulsive Guidance Molecule Acts in Axon Branching in Caenorhabditis elegans
Authors: Tsutsui Kaname , Kim Hon-Song , Yoshikata Chizu , Kimura Kenji , Kubota Yukihiko , Shibata Yukimasa , Tian Chenxi , Liu Jun , Nishiwaki Kiyoji 
Published: September 2021

Abstract
Repulsive guidance molecules (RGMs) are evolutionarily conserved proteins implicated in repulsive axon guidance. Here we report the function of the Caenorhabditis elegans ortholog DRAG-1 in axon branching. The axons of hermaphrodite-specific neurons (HSNs) extend dorsal branches at the region abutting the vulval muscles. The drag-1 mutants exhibited defects in HSN axon branching in addition to a small body size phenotype. DRAG-1 expression in the hypodermal cells was required for the branching of the axons. Although DRAG-1 is normally expressed in the ventral hypodermis excepting the vulval region, its ectopic expression in vulval precursor cells was sufficient to induce the branching. The C-terminal glycosylphosphatidylinositol anchor of DRAG-1 was important for its function, suggesting that DRAG-1 should be anchored to the cell surface. Genetic analyses suggested that the membrane receptor UNC-40 acts in the same pathway with DRAG-1 in HSN branching. We propose that DRAG-1 expressed in the ventral hypodermis signals via the UNC-40 receptor expressed in HSNs to elicit branching activity of HSN axons.
Diagnostic Performance of Endoscopic Ultrasound-Guided Tissue Acquisition by EUS-FNA versus EUS-FNB for Solid Pancreatic Mass Without ROSE: A Retrospective Study.
Authors: Wong Thanawin , Pattarapuntakul Tanawat , Netinatsuton Nisa , Ovartlarnporn Bancha , Sottisuporn Jaksin , Chamroonkul Naichaya , Sripong Pimsiri , Jandee Sawangpong , Kaewdech Apichart , Piratvisuth Teerha 
Published: September 2021

Abstract
Background: Endoscopic ultrasound-guided tissue acquisition (EUS-TA) is an established diagnostic procedure for solid pancreatic mass. However, the diagnostic yield between fineneedle aspiration (FNA) and fine-needle biopsy (FNB) remains unclear. Thus, we aimed to evaluate and compare the diagnostic yields between FNA and FNB using conventional FNA and Franseen needles of the same size (22 gauge), respectively, in patients with solid pancreatic mass who underwent EUS-TA without rapid onsite cytopathology evaluation (ROSE). Methods: All cases of EUS-TA by FNA or FNB for solid pancreatic mass between January 2017 and October 2020 in a single center university hospital were retrospectively reviewed. The procedure was performed without an onsite cytologist. After macroscopic onsite evaluation (MOSE), the endoscopist finished the procedure. The diagnostic yield and the average number of needle passes between FNB and FNA were then compared. Results: A total of 151 patients (FNA, n = 77; FNB, n = 74) with solid pancreatic mass detected by cross-sectional imaging underwent EUS-TA. The mean age was 62.3 ± 12.8 years, with 88 (58.3%) males. Age, gender, mass location, tumour size and disease stage from imaging were not significantly different. The diagnostic performance was dramatically higher in EUS-FNB (100%) than in EUS-FNA (89.6%). The mean number of needle passes was clearly fewer in FNB than FNA (2.8 vs. 3.8, p < 0.001). The total procedure time was less in FNB (34.7 minutes) than in FNA (41 minutes). The adverse event rate between FNB and FNA was not significantly different. Conclusions: The diagnostic performance for solid pancreatic mass without ROSE was significantly higher in FNB than in FNA. The number of needle passes and the total procedure time was also lesser in FNB.