bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular Diversity Assessment using Chemotypes
Authors: Villar Hugo O. , Mandayan Raghav , Hansen Mark R. 
Published: February 2021

Background:
Many techniques to design chemical libraries for screening have been put
forward over time. General use libraries are still important when screening against novel targets,
and their design has relied on the use of molecular descriptors. In contrast, chemotype or scaffold
analysis has been used less often.

Objective:
We describe a simple method to assess chemical diversity based on counts of the chemotypes
that offers an alternative to model chemical diversity. We describe a simple method to assess
chemical diversity based on counts of the chemotypes that offers an alternative to model chemical
diversity based on computed molecular properties. We show how chemotype counts can be used to
evaluate the diversity of a library and compare diversity selection algorithms. We demonstrate an
efficient compound selection algorithm based on chemotype analysis.

Methods:
We use automated chemotype perception algorithms and compare them to traditional
techniques for diversity analysis to check their effectiveness in designing diverse libraries for
screening.

Results:
The best type of molecular fingerprints for diversity selection in our analysis are extended
circular fingerprints, but they can be outperformed by the use of a chemotype diversity algorithm,
which can be more intuitive than traditional techniques based on molecular descriptors. Chemotype-
-based algorithms retrieve a larger share of the chemotypes contained in a library when picking a
subset of the chemicals in a collection.

Conclusions:
Chemotype analysis offers an alternative for the generation of a general-purpose
screening library as it maximizes the number of chemotypes present in a subset with the smallest
number of compounds. The applications of methods based on chemotype analysis that does not resort
to the use of molecular descriptors are a very promising but seldom explored area of chemoinformatics.
3D Shape Segmentation: A Review
Authors: Peng Qingjin , Li Rui 
Published: February 2021

Background:
Shape segmentation is commonly required in many engineering fields to separate a 3D shape into pieces for some specific applications. Although there are different methods proposed to segment the 3D shape, there is a lack of analyses of their efficiency and accuracy. It is a challenge to select an effective method to meet a particular requirement of the shape segmentation.

Objective:
This paper reviews existing methods of the shape segmentation to summarize the methods and processes to identify their pros and cons.

Method:
The process of the shape segmentation is summarized in two steps of the feature extraction and model separation.

Results:
Shape features are identified from the available methods. Different methods of the shape segmentation are evaluated. The challenge and trend of the shape segmentation are discussed.

Conclusion:
Clustering is the most used method for the shape segmentation. Machine learning methods are trend of 3D shape segmentations for identification, analysis and reconstruction of large-scale models.
Developing a Web-Based Shared Decision-Making Tool for Fertility Preservation Among Reproductive-Age Women With Breast Cancer: An Action Research Approach
Authors: Tseng Ling-Ming , Lien Pei-Ju , Huang Chen-Yu , Tsai Yi-Fang , Chao Ta-Chung , Huang Sheng-Miauh 
Published: February 2021

Background
The pregnancy rate after cancer treatment for female survivors is lower than that of the general population. Future infertility is a significant concern for patients with breast cancer and is associated with a poor quality of life. Reproductive-age patients with breast cancer have safe options when choosing a type of fertility preservation method to be applied. Better information and support resources aimed at women to support their decision making are needed.

Objective
The objective of this study was to develop a web-based shared decision-making tool for helping patients with breast cancer make decisions on fertility preservation.

Methods
We used the action research cycle of observing, reflecting, planning, and acting to develop a web-based shared decision-making tool. The following four phrases were applied: (1) observe and reflect—collect and analyze the decision-making experiences of patients and health care providers; (2) reflect and plan—apply the initial results to create a paper design and modify the content; (3) plan and act—brainstorm about the web pages and modify the content; (4) act and observe—evaluate the effectiveness and refine the website’s shared decision-making tool. Interviews, group meetings, and constant dialogue were conducted between the various participants at each step. Effectiveness was evaluated using the Preparation for Decision-Making scale.

Results
Five major parts were developed with the use of the action research approach. The Introduction (part 1) describes the severity of cancer treatment and infertility. Options (part 2) provides the knowledge of fertility preservation. The shared decision-making tool was designed as a step-by-step process (part 3) that involves the comparison of options, patient values, and preferences; their knowledge regarding infertility and options; and reaching a collective decision. Resources (part 4) provides information on the hospitals that provide such services, and References (part 5) lists all the literature cited in the website. The results show the web-based shared decision-making meets both patients’ and health providers’ needs and helps reproductive-age patients with breast cancer make decisions about fertility preservation.

Conclusions
We have created the first web-based shared decision-making tool for making fertility preservation decisions in Taiwan. We believe female patients of reproductive age will find the tool useful and its use will become widespread, which should increase patient autonomy and improve communication about fertility preservation with clinicians.

Trial Registration
Clinicaltrials.gov NCT04602910; https://clinicaltrials.gov/ct2/show/NCT04602910
The Effect of Aqueous Fraction of Clinacanthusnutans (Burm.F.) Extract Microcapsules on Rat Blood Glucose Level
Authors: Narasukma Ebta , Cahyani Intan Martha , Retnaningsih Christiana , Ananingsih Victoria Kristina , Prahasiwi Masitoh Suryaning , Nugraheni Bekti , Sari Afri Diyah Nur Indah 
Published: February 2021

Diabetes mellitus is a common metabolic disease marked by hyperglycemia. Diabetes also can be caused by oxidative stress. The administration of antioxidants, whether it’s from food or supplement can inhibit the formation of free radicals. Clinacanthus nutans is reported to possess various medicinal properties including blood glucose lowering effect, alpha-glucosidase inhibition activity, antioxidant activities, anti-cancer properties and anti-inflammatory effects. Based on research Clinacanthus nutans leaf extracts fractions has several shortcomings, amongst them are its viscosity that gave difficulties in formulation and its astringent and bitter taste that made it hard to use orally. To overcome these shortcomings, microencapsulation can be used. The purpose of this research is to find the blood glucose level lowering effect of the aqueous fraction of microcapsules and to find the effective dose on fructose and fat-induced Wistar strain rat. The induction using fructose and high-fat feed for 55 days was applied. Rats were divided into 8 groups: normal control (aquadest), negative control (Arabic gum and maltodextrin), positive control (metformin), dose I 15,89 mg/ kgBW (microcapsule of aqueous fraction of Clinacanthus nutans extract), dose II 31,78 mg/ kgBW, dose III 47,67 mg/ kgBW, dose IV 63.56 mg /kgBW, and dose V 79.45 mg/ kgBW. The result showed that the microcapsules of the aqueous fraction of Clinacanthus nutans (Burm.f) extract could lower Wistar strain rat blood glucose level in the dose of 15.89 mg/kg of the rat’s body weight.
DISTRIBUTION AND COMPOSITION OF THE MAIN ACTIVE COMPONENTS FOUND IN STINGLESS BEE PROPOLIS FROM VARIOUS REGIONS IN INDONESIA
Authors: MAHANI  , MICHELLE  , CAHYANA YANA , SULAEMAN AHMAD , HARDINSYAH  , NURJANAH NUNUNG , SUNARNO  , SARIADJI KAMBANG 
Published: February 2021

Objective: The aim of this study is to map out the distribution and composition of the main active components found in stingless bee propolis from various regions in Indonesia.
Methods: The stingless bee propolis used was obtained from ten different provinces in Indonesia and the active components analysis using Gas Chromatography-Mass Spectrometer (GC-MS) pyrolyzer.
Results: This study found 85 main types of active components with concentrations of ≥ 1%. The most frequently found active component was alpha-d-glucopyranoside, which had an average concentration of 28.20%.
Conclusion: There were differences between the main active components found in 14 samples of stingless bee propolis obtained from 10 provinces in Indonesia, which was due to the variety of bee species and plant origin.
Development of nanomodified multifunctional protection systems for wood structures
Authors: Pokrovskaya Elena N. 
Published: February 2021

Introduction. Nowadays multi-storey buildings, composed of wood structures, are built in different countries. The durabi-lity of structures depends to a large extent on the protection systems used. The most effective ones are multifunctional protection systems that rise the fire protection ability, hydrophobicity, and biostability of structural materials. The application of carbon nanotubes is expected to improve the uniformity of a protective layer and the coating performance. The purpose of the project is to develop a multifunctional protection system designated for wood structures. This system must ensure their fire resistance and hydrophobicity without deteriorating the mechanical properties of wood.
Materials and methods. Pine wood samples were used in the research. Carbon nanotubes were used as nano-modifiers. Wood samples, surface-modified with methylphosphonic (MPH) and nitrilo-trimethylphosphonic (NPH) acids, were used to develop multifunctional protection systems. Integrated protection systems were developed by adding carbon nanotubes. Fire hazard properties were assessed pursuant to GOST 27484-87, water absorption properties were analyzed pursuant to GOST 16483.20-72, mechanical properties were addressed with reference to GOST 16483.11-72 and 16483.10-73. Hydrophobicity was evaluated using the wetting angle method. The character of the sample surface and its chemical composition were studied using the double-beam scanning electron-ion microscope FEI Quanta 3D FEG with an EDAX Octane select attachment needed for the energy dispersion analysis.
Results. All studied coating systems belong to the first group of the fire retardant efficiency, the best of them reduce weight loss in the course of combustion of samples: Δweight = 3.7 – 1.34 %. Wood develops hydrophobic properties; its water absorption reduces 1.5-fold, while its across-fiber mechanical compressive strength goes up 1.6-fold. The assessment of the wood surface and its chemical composition shows that high fire resistance correlates with higher phosphorus content in the char layer formed during combustion.
Conclusions. Surface modification of wood by protection systems is recommended as an effective means of rising the durability of structures.
Pola Hubungan Guru Dan Orangtua Dalam Pendidikan Pada Madrasaah Aliyah Negeri Di Aceh Tamiang
Authors: Saleh Muhammad 
Published: February 2021

Community paradigm of education has changed, one of the things that changes the learning paradigm is the application of cooperation between parents and teachers in learning. Applying the pattern of teacher and parent relations in education at Madrasah Aliyah Negeri in Aceh Tamiang, is a relationship pattern that can establish communication between teachers and parents in education in MAN ManyakPayed and MAN Kualasimpang. This study aims to determine the roles and functions, form of communication, shared responsibility, form of cooperation, form of effort between teachers and parents in MAN ManyakPayed and MAN Kualasimpang in Aceh Tamiang. This research uses qualitative approach. Subjects in this study were teachers and parents at MAN Aceh Tamiang. As for data collection techniques in this study include observation and interviews. Furthermore, Based on the results of data analysis, it is known that the role and function of teachers and parents as partners, guide, direct and supervise. Form of communication is by through an official letter from the school and a visit to the home of his parents in order to know the true condition of the students. The efforts of teachers and parents in MAN and MAN Kualasimpang provide motivation to learn, create a harmonious atmosphere in the family, providing for the needs of children.
Standardizing Sign-out With I-PASS Handoff in Family Medicine Residency
Authors: Sonoda Kento , Nakaishi Lindsay , Salter Cynthia 
Published: February 2021

Introduction: Handoff miscommunications are a leading cause of medical errors. A structured handoff is an effective communication tool. We introduced the I-PASS Handoff Bundle for resident sign-out in the inpatient setting. We aimed to reduce preventable adverse events and unexpected floor calls while also improving residents’ confidence and preparedness to care for patients overnight.
Methods: We conducted an observational study at a single-site family medicine residency between April 2019 and March 2020. Residents received trainings in the I-PASS standardized handoff through didactic lectures and on-the-job sessions in September and November 2019. We evaluated the effectiveness of the I-PASS Handoff Bundle by comparing pre- and postimplementation data including number of medical errors and unexpected floor calls, along with residents’ reported levels of preparedness and confidence to care for patients overnight.
Results: Prior to the I-PASS intervention, more than half of resident surveys included at least one unexpected floor call whereas postintervention about one-third of resident surveys included unexpected floor calls (P&lt;.05). However, the intervention did not significantly affect residents’ confidence level in caring for patients overnight and residents’ rating of the usefulness of anticipatory guidance for managing night floor calls. We did not identify any medical errors related to communication issues at patient handoff within the family medicine service.
Conclusion: I-PASS intervention significantly reduced unexpected floor calls. However, the intervention did not improve residents’ reported confidence and preparedness to care for patients overnight.
EFEKTIVITAS MEDIA E-LEARNING DENGAN MODEL BLENDED LEARNING PADA MATA PELAJARAN GEOGRAFI KELAS X DI SMA NEGERI 2 BANJAR
Authors: Utami Gusti Ayu Indah , Sugihartini Nyoman , Wahyuni Dessy Seri 
Published: February 2021

Penelitian ini bertujuan untuk mengembangkan dan mengimplementasikan media e-laerning, serta mengetahui bagaimana respons guru dan peserta didik terhadap media e-learning dengan model blended learning pada mata pelajaran geografi kelas X di SMA Negeri 2 Banjar. Penelitian ini menggunakan model pengembangan ADDIE dan penelitian ini termasuk jenis penelitian dan pengembangan (R & D). Adapun tahapan dari model pengembangan ADDIE yaitu, analyze, design, development, implementation, evaluasion. Penelitian ini dilakukan di kelas X Bahasa dan Budaya 2 SMA Negeri 2 Banjar dengan jumlah 10 peserta didik. Dalam pengambilan data dalam penelitian ini menggunakan beberapa instrument di antaranya yaitu angket validasi ahli isi, desain pembelajaran dan media pembelajaran, angket uji perorangan, kelompok kecil dan lapangan, serta angket respons guru dan peserta didik. Hasil dari uji kevalidan media e-learning yang dihitung dari hasil validasi ahli yaitu ahli isi, desain pembelajaran, dan media mendapatkan rata-rata skor sebesar 1,00 dengan kriteria sangat valid. Hasil rata-rata dari respons guru mendapatkan skor sebesar 47 dan untuk hasil rata-rata respons peserta didik medapatkan rata-rata sebesar 60,3 dengan kriteria sangat praktis. Simpulan dari penelitian ini yaitu media e-learning pada mata pelajaran geografi telah memenuhi kriteria kualitas produk yaitu kevalidan dan kepraktisan. Kata kunci: Blended Learning, Media Pembelajaran, Model ADDIE
METHOD OF TELEPORTATION BASED ON NATURE-LIKE USING OF BIOLOGICAL OBJECTS
Authors: Gavrilov Vladimir , Antipova Tatyana , Vlasov Yan , Ardatov Sergey , Ardatova Anastasia 
Published: February 2021

SEFER hA MINAGIM, p. 574 (photo 1), on behalf of an older book, writes that according to Jewish tradition, the navel does not close completely after childbirth, but remains partially open to extract various infections from the body. "From the "greenness" called "gable- zaht" (די קרענק איז דזשאָנדאַס – disease jaundice), he will take a male pigeon for a man, and a dove for a woman; and put it on the navel, and the pigeon (dove), having drained all the infection from it (the patient), will die. Well-known veterinarian, Dr. Yekutiel Sharabi, owner of an elite veterinary clinic in Northern Tel Aviv, studied the causes of pigeon death after such a session. He found that immediately after treatment with pigeons, the patient's blood bilirubin level decreases by 25%, and recovery lasts an average of 3 days (as opposed to 28 days with conventional treatment). Autopsies of pigeons that died after the session showed liver enlargement and dysfunction. If the session was applied to a healthy person, not a single pigeon died. [1]
In this paper, we consider a heuristic method for using quantum teleportation protocols in convergent dual-use biotechnologies based on new physical principles of operation [1-80]. The features of these biotechnologies will be considered within the framework of the possibilities of convalescence of pathological conditions (for example, nosological form: liver damage (lat. jecur, jecor, hepar, etc. Greek - ἧπαρ) by the hepatitis "C" virus (non-A, non-B hepatitis, or NANBH, or HCV infection). A hypothetical convalescence technology can be implemented by preparing cascades of entangled states of biological objects. In fact, this paper implies a certain information exchange in the planet's biogeosphere, hypotheses, protocols, and schemes for implementing these mechanisms based on new physical principles of action [1-80].
Issues of coreection of intestinal microbiocenosis in different aspects of treatment of liver oncological diseases
Authors: Sorokina Leya , Kubyshkin Anatoliy , Fomochkina Iryna , Gorbunov Alexander , Regan Olga , Rebik Anastasia 
Published: February 2021

Introduction. The relevance of the topic presented is due to the increased interest of the
scientific world to the issue of the functioning of the «microbiota-intestine-liver» axis.
Aims. To study the biochemical and molecular aspects of the functioning of the network
«microbiota-intestine-liver» as a potential target for the treatment of liver cancer.
Materials and methods. The HCC model was created in C57Bl/6 mice using the Hera 1-6 cell
line. The study used molecular, morphological, instrumental methods and statistical analysis.
Results. In the course of the work, the level of expression of molecular markers, reflecting the
degree of changes in the hepatic parenchyma and the level of the antitumor immune response when
modifying the composition of the intestinal microflora, was determined, and the dynamics of the
development of the tumor process during the pharmacological correction of the revealed changes in
primary liver cancer by the use of various groups of drugs was assessed.
Conclusion. It has been shown that a violation of the intestinal microflora can contribute to
chronic inflammation, the progression of changes in the liver parenchyma with its replacement by
fibrous tissue or accumulation of fat, as well as directly suppress antitumor immune responses.
Аcknowledgments. This work was financially supported by state task № FZEG-2020-0060 of
the Russian Ministry of Science «Algorithms for molecular genetics diagnosis of malignant neoplasms
and approaches to their targeted therapy using cellular and genetic technologies» and partially
supported by the V.I. Vernadsky Crimean Federal University Development Program for 2015-2024
Robert SERVICE, «La balada de la piel del zorro negro»
Authors: Quirosa Emma 
Published: February 2021

Robert Service nació en el seno de una familia escocesa en el año 1874, en Preston al norte de Inglaterra. Cuando cumplió veintiún años se fue a vivir a Canadá. Allí trabajó en varias sucursales de un banco a lo largo de todo el país norteamericano. Dos de dichas sucursales estaban en el Territorio del Yukón. Primero, en 1904, el banco le trasladó a la ciudad de Whitehorse. Para entonces él ya tenía cierto éxito con sus poemas y como comenzaba a ser famoso, los lugareños le visitaban en el banco solo para verle. Más tarde, en 1908, el banco le trasladó a la ciudad de Dawson, también en el Territorio del Yukón. Esto fue poco después de la época de la fiebre de oro, la cual le inspiró a Robert Service para escribir más poemas sobre las tierras del norte.
Sin embargo, no era Robert Service un hombre de costumbres o de vida salvajes. En realidad, según Wallace Lockhart (1999: p. 50), sus lectores se extrañaban de encontrar a un hombre tímido con una vida tranquila. De hecho, durante su época en la ciudad de Whitehorse ejercía de ministro a tiempo parcial como decano de una iglesia episcopal, puesto para el que fue propuesto por el jefe de su banco.
Después de ocho años en el norte de Canadá, entre 1904 y 1911, Robert Service dejó la ciudad de Dawson para viajar por todo el mundo. En el año 1913 se casó con la francesa Germaine Bourgoin. Vivieron quince años en París a partir del año 1913. En el año 1914, debido a su mala salud, Robert Service fue rechazado por el ejército, para luchar en la Primera Guerra Mundial. Debido a este contratiempo, en el año 1916 se unió al Servicio Americano de la Cruz Roja en Francia.
En Bretaña, Francia, la pareja se compró una casa a la que denominaron «Dream Haven» (Refugio de ensueño) y tiempo después fueron padres de dos niñas gemelas. En 1921 visitaron Hollywood donde convirtieron una de sus novelas en una película. A partir del año 1929 vivieron una vida más tranquila y familiar en la Costa Azul francesa, siempre escribiendo y publicando. Robert Service murió en el año 1958 en Francia.
Muchas veces le han llamado el «Bardo del Yukón» ya que es famoso por los poemas suyos que describen ese lugar. En total, Robert Service escribió más de mil poemas durante su vida. El poema aquí traducido: «The Ballad of the Black Fox Skin» (Service, 1993: pp. 18-22), data del año 1909. Originalmente escrito en inglés este también elige como escenario el Territorio del Yukón. Robert Service lo escribió mientras vivía en la ciudad de Dawson. El poema cuenta una historia, describe los personajes peculiares de la zona y la vida bárbara del lugar. El poema tiene un final muy atractivo y termina con una moraleja.