bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone marrow mesenchymal stem cells transfer in patients with ST-segment elevation myocardial infarction: single-blind, multicenter, randomized controlled trial
Authors: Zhang Runfeng , Yu Jiang , Zhang Ningkun , Li Wensong , Wang Jisheng , Cai Guocai , Chen Yu , Yang Yong , Liu Zhenhong 
Published: January 2021

Abstract
Objective
Our aim was to evaluate the efficacy and safety of intracoronary autologous bone marrow mesenchymal stem cell (BM-MSC) transplantation in patients with ST-segment elevation myocardial infarction (STEMI).

Methods
In this randomized, single-blind, controlled trial, patients with STEMI (aged 39–76 years) were enrolled at 6 centers in Beijing (The People’s Liberation Army Navy General Hospital, Beijing Armed Police General Hospital, Chinese People’s Liberation Army General Hospital, Beijing Huaxin Hospital, Beijing Tongren Hospital, Beijing Chaoyang Hospital West Hospital). All patients underwent optimum medical treatment and percutaneous coronary intervention and were randomly assigned in a 1:1 ratio to BM-MSC group or control group. The primary endpoint was the change of myocardial viability at the 6th month’s follow-up and left ventricular (LV) function at the 12th month’s follow-up. The secondary endpoints were the incidence of cardiovascular event, total mortality, and adverse event during the 12 months’ follow-up. The myocardial viability assessed by single-photon emission computed tomography (SPECT). The left ventricular ejection fraction (LVEF) was used to assess LV function. All patients underwent dynamic ECG and laboratory evaluations. This trial is registered with ClinicalTrails.gov, number NCT04421274.

Results
Between March 2008 and July 2010, 43 patients who had underwent optimum medical treatment and successful percutaneous coronary intervention were randomly assigned to BM-MSC group (n = 21) or control group (n = 22) and followed-up for 12 months. At the 6th month’s follow-up, there was no significant improvement in myocardial activity in the BM-MSC group before and after transplantation. Meanwhile, there was no statistically significant difference between the two groups in the change of myocardial perfusion defect index (p = 0.37) and myocardial metabolic defect index (p = 0.90). The LVEF increased from baseline to 12 months in the BM-MSC group and control group (mean baseline-adjusted BM-MSC treatment differences in LVEF 4.8% (SD 9.0) and mean baseline-adjusted control group treatment differences in LVEF 5.8% (SD 6.04)). However, there was no statistically significant difference between the two groups in the change of the LVEF (p = 0.23). We noticed that during the 12 months’ follow-up, except for one death and one coronary microvascular embolism in the BM-MSC group, no other events occurred and alanine transaminase (ALT) and C-reactive protein (CRP) in BM-MSC group were significantly lower than that in the control group.

Conclusions
The present study may have many methodological limitations, and within those limitations, we did not identify that intracoronary transfer of autologous BM-MSCs could largely promote the recovery of LV function and myocardial viability after acute myocardial infarction.
Ultraprotective ventilation allowed by extracorporeal CO2 removal improves the right ventricular function in acute respiratory distress syndrome patients: a quasi-experimental pilot study
Authors: Goursaud Suzanne , Valette Xavier , Dupeyrat Julien , Daubin Cédric , du Cheyron Damien 
Published: January 2021

Abstract
Background
Right ventricular (RV) failure is a common complication in moderate-to-severe acute respiratory distress syndrome (ARDS). RV failure is exacerbated by hypercapnic acidosis and overdistension induced by mechanical ventilation. Veno-venous extracorporeal CO2 removal (ECCO2R) might allow ultraprotective ventilation with lower tidal volume (VT) and plateau pressure (Pplat). This study investigated whether ECCO2R therapy could affect RV function.

Methods
This was a quasi-experimental prospective observational pilot study performed in a French medical ICU. Patients with moderate-to-severe ARDS with PaO2/FiO2 ratio between 80 and 150 mmHg were enrolled. An ultraprotective ventilation strategy was used with VT at 4 mL/kg of predicted body weight during the 24 h following the start of a low-flow ECCO2R device. RV function was assessed by transthoracic echocardiography (TTE) during the study protocol.

Results
The efficacy of ECCO2R facilitated an ultraprotective strategy in all 18 patients included. We observed a significant improvement in RV systolic function parameters. Tricuspid annular plane systolic excursion (TAPSE) increased significantly under ultraprotective ventilation compared to baseline (from 22.8 to 25.4 mm; p < 0.05). Systolic excursion velocity (S’ wave) also increased after the 1-day protocol (from 13.8 m/s to 15.1 m/s; p < 0.05). A significant improvement in the aortic velocity time integral (VTIAo) under ultraprotective ventilation settings was observed (p = 0.05). There were no significant differences in the values of systolic pulmonary arterial pressure (sPAP) and RV preload.

Conclusion
Low-flow ECCO2R facilitates an ultraprotective ventilation strategy thatwould improve RV function in moderate-to-severe ARDS patients. Improvement in RV contractility appears to be mainly due to a decrease in intrathoracic pressure allowed by ultraprotective ventilation, rather than a reduction of PaCO2.
Self-determination theory interventions versus usual care in people with diabetes: a protocol for a systematic review with meta-analysis and trial sequential analysis
Authors: Mathiesen Anne Sophie , Rothmann Mette Juel , Zoffmann Vibeke , Jakobsen Janus Christian , Gluud Christian , Lindschou Jane , Due-Christensen Mette , Rasmussen Bodil , Marqvorsen Emilie , Thomsen Thordis 
Published: January 2021

Abstract
Background
Existing self-management and behavioural interventions for diabetes vary widely in their content, and their sustained long-term effectiveness is uncertain. Autonomy supporting interventions may be a prerequisite to achieve ‘real life’ patient engagement and more long-term improvement through shared decision-making and collaborative goal setting. Autonomy supportive interventions aim to promote that the person with diabetes’ motivation is autonomous meaning that the person strives for goals they themselves truly believe in and value. This is the goal of self-determination theory and guided self-determination interventions. Self-determination theory has been reviewed but without assessing both benefits and harms and accounting for the risk of random errors using trial sequential analysis. The guided self-determination has not yet been systematically reviewed. The aim of this protocol is to investigate the benefits and harms of self-determination theory-based interventions versus usual care in adults with diabetes.

Methods/design
We will conduct the systematic review following The Cochrane Collaboration guidelines. This protocol is reported according to the PRISMA checklist. A comprehensive search will be undertaken in the CENTRAL, MEDLINE, EMBASE, LILACS, PsycINFO, SCI-EXPANDED, CINAHL, SSCI, CPCI-S and CPCI-SSH to identify relevant trials. We will include randomised clinical trials assessing interventions theoretically based on guided self-determination or self-determination theory provided face-to-face or digitally by any healthcare professional in any setting. The primary outcomes will be quality of life, mortality, and serious adverse events. The secondary will be diabetes distress, depressive symptoms and adverse events not considered serious. Exploratory outcomes will be glycated haemoglobin and motivation. Outcomes will be assessed at the end of the intervention and at maximum follow-up. The analyses will be performed using Stata version 16 and trial sequential analysis. Two authors will independently screen, extract data from and perform risk of bias assessment of included studies using the Cochrane risk of bias tool. Certainty of the evidence will be assessed by GRADE.

Discussion
Self-determination theory interventions aim to promote a more autonomous patient engagement and are commonly used. It is therefore needed to evaluate the benefit and harms according to existing trials.

Systematic review registration
PROSPERO CRD42020181144
The use of theories, frameworks, or models in knowledge translation studies in healthcare settings in China: a scoping review protocol
Authors: Zhao Junqiang , Li Xuejing , Yan Lijiao , Yu Yamei , Hu Jiale , Li Shelly-Anne , Chen Wenjun 
Published: January 2021

AbstractBackgroundKnowledge translation (KT) theories, frameworks, and models (TFMs) can help guide and explain KT processes, and facilitate the evaluation of implementation outcomes. They play a critical role in conducting KT research and practice. Currently, little is known about the usage of TFMs in KT in Chinese healthcare settings. The aim of this scoping review is to identify which TFMs had been used for KT in healthcare settings in China, and how these TFMs were used.MethodsThe protocol for this scoping review is in accordance with the Arksey and O’Malley framework and further enhanced by the recommendations suggested by Levac et al. We will search 8 databases (4 Chinese and 4 English) to identify relevant studies. Four reviewers (2 for Chinese, 2 for English) will independently screen studies based on the eligibility criteria. The basic characteristic of studies and the TFMs utilization (i.e., what, why, and how) will be extracted. Methodological quality and reporting quality will be assessed using the Mixed Method Appraisal Tool (MMAT) and the Standards for Reporting Implementation Studies (StaRI) (or Standards for Quality Improvement Reporting Excellence, SQUIRE 2.0 for quality improvement studies), respectively. All the retrieved TFMs will be categorized into Nilsen’s classifications of TFMs for KT research. We will employ the qualitative content analysis approach to summarize how these TFMs have been used, and the rationale. A consultation will be conducted through a 1-h interactive virtual meeting with an expert panel of knowledge users.DiscussionBy conducting this scoping review, we expect to gain a comprehensive and in-depth understanding of why and how TFMs have been used in KT research and practice in China, and to identify gaps and provide recommendations for more efficient and meaningful use of TFMs in the future.Systematic review registrationThis review has been registered with the Open Science Framework (10.17605/OSF.IO/8NXAM).
Steady state for a predator–prey cross-diffusion system with the Beddington–DeAngelis and Tanner functional response
Authors: Luo Demou 
Published: January 2021

AbstractThe main goal of this paper is investigating the existence of nonconstant positive steady states of a linear prey–predator cross-diffusion system with Beddington–DeAngelis and Tanner functional response. An analytical method and fixed point index theory plays a significant role in our main proofs.
The q-Sumudu transform and its certain properties in a generalized q-calculus theory
Authors: Al-Omari Shrideh Khalaf 
Published: January 2021

AbstractIn this paper we consider a generalization to the q-calculus theory in the space of q-integrable functions. We introduce q-delta sequences and develop q-convolution products to derive certain q-convolution theorem. By using the concept of q-delta sequences, we establish various axioms and set up q-spaces of generalized functions named q-Boehmian spaces. The new assigned spaces of q-generalized functions are acceptable and compatible with the classical spaces of the ordinary functions. Consequently, we extend the generalized q-Sumudu transform to the sets of q-Boehmian spaces. On top of that, we nominate the canonical q-embeddings between the q-integrable sets of functions and the q-integrable sets of q-Boehmians. Furthermore, we address the general properties of the generalized q-Sumudu transform and its inversion formula in some detail.
On the weighted fractional integral inequalities for Chebyshev functionals
Authors: Rahman Gauhar , Nisar Kottakkaran Sooppy , Khan Sami Ullah , Baleanu Dumitru , Vijayakumar V. 
Published: January 2021

AbstractThe goal of this present paper is to study some new inequalities for a class of differentiable functions connected with Chebyshev’s functionals by utilizing a fractional generalized weighted fractional integral involving another function$\mathcal{G}$Gin the kernel. Also, we present weighted fractional integral inequalities for the weighted and extended Chebyshev’s functionals. One can easily investigate some new inequalities involving all other type weighted fractional integrals associated with Chebyshev’s functionals with certain choices of$\omega (\theta )$ω(θ)and$\mathcal{G}(\theta )$G(θ)as discussed in the literature. Furthermore, the obtained weighted fractional integral inequalities will cover the inequalities for all other type fractional integrals such as Katugampola fractional integrals, generalized Riemann–Liouville fractional integrals, conformable fractional integrals and Hadamard fractional integrals associated with Chebyshev’s functionals with certain choices of$\omega (\theta )$ω(θ)and$\mathcal{G}(\theta )$G(θ).
Mathematical analysis of tuberculosis control model using nonsingular kernel type Caputo derivative
Authors: Ahmad Saeed , Ullah Rafi , Baleanu Dumitru 
Published: January 2021

AbstractThis research work investigates some theoretical and semi-analytical results for the mathematical model of tuberculosis disease via derivative due to Caputo and Fabrizio. The concerned derivative involves exponential kernel and very recently it has been adapted for various applied problems. The required results are established by using some fixed point approach of Krasnoselskii and Banach. Further, by the use of iterative tools of Adomian decomposition and Laplace, the semi-analytical results are studied. Some graphical results are given with discussion.
Quantum variant of Montgomery identity and Ostrowski-type inequalities for the mappings of two variables
Authors: Ali Muhammad Aamir , Chu Yu-Ming , Budak Hüseyin , Akkurt Abdullah , Yıldırım Hüseyin , Zahid Manzoor Ahmed 
Published: January 2021

AbstractIn this investigation, we demonstrate the quantum version of Montgomery identity for the functions of two variables. Then we use the result to derive some new Ostrowski-type inequalities for the functions of two variables via quantum integrals. We also consider the particular cases of the key results and offer some new integral inequalities.
A study of a coupled system of Hadamard fractional differential equations with nonlocal coupled initial-multipoint conditions
Authors: Ahmad Bashir , Ntouyas Sotiris K. , Alsaedi Ahmed , Albideewi Amjad F. 
Published: January 2021

AbstractIn this paper, we obtain the existence results for a coupled system of Hadamard fractional differential equations supplemented with nonlocal coupled initial-multipoint conditions via fixed point theorems. An example is constructed for the illustration of the uniqueness result.
Disentangling depression in Belgian higher education students amidst the first COVID-19 lockdown (April-May 2020)
Authors:   for the Belgian COVID-19 International Student Well-being Study (C19 ISWS) team, De Man Jeroen , Buffel Veerle , van de Velde Sarah , Bracke Piet , Van Hal Guido F. , Wouters Edwin 
Published: January 2021

Abstract
Background
The surge of COVID-19 infections has prompted many countries to take unprecedented policy measures. In Belgium, the authorities implemented a nation-wide stay-at-home order for several months. Evidence of the mental health effect of such measures is scarce. A recent review by Brooks et al. has compiled a defined list of stressors affecting people’s mental health under quarantine during previous epidemic settings. This study aims to test the association between these stressors and the mental health of students attending higher education during the stay-at-home order in Belgium.

Methods
In this cross-sectional study, 18,301 students from 13 higher education institutions (HEI) participated in an online survey between 26 April and 11 May 2020. We assessed the association between potential stressors and depressive symptoms severity scores and structural equation modeling was used to assess how stressors may mediate the association between duration of exposure and depressive symptoms severity.

Results
The stressors proposed by Brooks et al. were found to be associated with depressive symptoms severity. The stressors ‘perceived academic stress’, ‘institutional dissatisfaction’ and ‘fear of being infected’ were associated with substantially higher depressive symptoms severity scores. The association between duration of exposure and depressive symptoms severity was mediated by ‘academic stress’. Being in a steady relationship and living together with others were both associated with a lower depressive symptoms severity.

Conclusion
Findings underline the need for a student-centered approach and mental health prevention. Authorities and HEIs should consider whether and if so, how a stay-at-home order should be implemented.
Context matters in understanding the vulnerability of women: perspectives from southwestern Uganda
Authors: Murembe Neema , Kyomuhangi Teddy , Manalili Kimberly , Beinempaka Florence , Nakazibwe Primrose , Kyokushaba Clare , Tibanyendera Basil , Brenner Jennifer L. , Turyakira Eleanor 
Published: January 2021

Abstract
Background
Vulnerability at the individual, family, community or organization level affects access and utilization of health services, and is a key consideration for health equity. Several frameworks have been used to explore the concept of vulnerability and identified demographics including ethnicity, economic class, level of education, and geographical location. While the magnitude of vulnerable populations is not clearly documented and understood, specific indicators, such as extreme poverty, show that vulnerability among women is pervasive. Women in low and middle-income countries often do not control economic resources and are culturally disadvantaged, which exacerbates other vulnerabilities they experience. In this commentary, we explore the different understandings of vulnerability and the importance of engaging communities in defining vulnerability for research, as well as for programming and provision of maternal newborn and child health (MNCH) services.

Methodology
In a recent community-based qualitative study, we examined the healthcare utilization experiences of vulnerable women with MNCH services in rural southwestern Uganda. Focus group discussions were conducted with community leaders and community health workers in two districts of Southwestern Uganda. In addition, we did individual interviews with women living in extreme poverty and having other conventional vulnerability characteristics.

Findings and discussion
We found that the traditional criteria of vulnerability were insufficient to identify categories of vulnerable women to target in the context of MNCH programming and service provision in resource-limited settings. Through our engagement with communities and through the narratives of the people we interviewed, we obtained insight into how nuanced vulnerability can be, and how important it is to ground definitions of vulnerability within the specific context. We identified additional aspects of vulnerability through this study, including: women who suffer from alcoholism or have husbands with alcoholism, women with a history of home births, women that have given birth only to girls, and those living on fishing sites.

Conclusion
Engaging communities in defining vulnerability is critical for the effective design, implementation and monitoring of MNCH programs, as it ensures these services are reaching those who are most in need.
The Clean pilot study: evaluation of an environmental hygiene intervention bundle in three Tanzanian hospitals
Authors: Gon Giorgia , Kabanywanyi Abdunoor M. , Blinkhoff Petri , Cousens Simon , Dancer Stephanie J. , Graham Wendy J. , Hokororo Joseph , Manzi Fatuma , Marchant Tanya , Mkoka Dickson , Morrison Emma , Mswata Sarah , Oza Shefali , Penn-Kekana Loveday , Sedekia Yovitha , Virgo Sandra , Woodd Susannah , Aiken Alexander M. 
Published: January 2021

Abstract
Background
Healthcare associated infections (HAI) are estimated to affect up to 15% of hospital inpatients in low-income countries (LICs). A critical but often neglected aspect of HAI prevention is basic environmental hygiene, particularly surface cleaning and linen management. TEACH CLEAN is an educational intervention aimed at improving environmental hygiene. We evaluated the effectiveness of this intervention in a pilot study in three high-volume maternity and newborn units in Dar es Salaam, Tanzania.

Methods
This study design prospectively evaluated the intervention as a whole, and offered a before-and-after comparison of the impact of the main training. We measured changes in microbiological cleanliness [Aerobic Colony Counts (ACC) and presence of Staphylococcus aureus] using dipslides, and physical cleaning action using gel dots. These were analysed with descriptive statistics and logistic regression models. We used qualitative (focus group discussions, in-depth interviews, and semi-structured observation) and quantitative (observation checklist) tools to measure why and how the intervention worked. We describe these findings across the themes of adaptation, fidelity, dose, reach and context.

Results
Microbiological cleanliness improved during the study period (ACC pre-training: 19%; post-training: 41%). The odds of cleanliness increased on average by 1.33 weekly during the pre-training period (CI = 1.11–1.60), and by 1.08 (CI = 1.03–1.13) during the post-training period. Cleaning action improved only in the pre-training period. Detection of S. aureus on hospital surfaces did not change substantially. The intervention was well received and considered feasible in this context. The major pitfalls in the implementation were the limited number of training sessions at the hospital level and the lack of supportive supervision. A systems barrier to implementation was lack of regular cleaning supplies.

Conclusions
The evaluation suggests that improvements in microbiological cleanliness are possible using this intervention and can be sustained. Improved microbiological cleanliness is a key step on the pathway to infection prevention in hospitals. Future research should assess whether this bundle is cost-effective in reducing bacterial and viral transmission and infection using a rigorous study design.