bluuebunny/crossref_metadata_2025_split huggingface dataset:
High prevalence of latent tuberculosis using the QuantiFERON-TB Gold Plus test in Takayasu arteritis
Authors: Luisa Souza Pedreira Ana , Pinheiro Leal Costa Rodrigo , Filipe Pitanga Silva Josenor , Barreto Santiago Mittermayer 
Published: December 2021

Objectives: This study aims to investigate latent tuberculosis using the QuantiFERON-TB Gold Plus method in patients with Takayasu arteritis (TA).
Patients and methods: This case-control study included 22 patients with TA (3 males, 19 females; median age: 36.5 years; IQR, 32 to 50 years), 22 healthy individuals (3 males, 19 females; median age: 38.5 years; IQR, 32.5 to 50 years), and 66 patients with diffuse connective tissue diseases (DCTDs) (4 males, 62 females; median age: 41 years; IQR, 29.8 to 54 years). Two control groups were formed: (i) age- and sex-matched healthy individuals and (ii) patients with other DCTDs. Epidemiological data were collected, and the QFT-Plus test was performed. The QFT-plus positivity was compared among the groups.
Results: A higher prevalence of QFT-Plus positive cases was observed in the TA group (8/22) than in the healthy control group (1/22) (p=0.020) or in the group with other DCTDs (3/66) (p=0.001). There was a statistically significant difference in the past pulmonary tuberculosis prevalence between the TA and DCTD groups (p=0.013).
Conclusion: The prevalence of latent tuberculosis in TA patients (36.4%) was higher than that in both control groups and higher than the prevalence of latent tuberculosis among the general Brazilian population. Although a positive association was found, it is not possible to establish a direct cause-effect relationship. Given the increasing use of anti-cytokine therapies in TA, it is necessary to thoroughly screen patients with TA before initiating immunosuppressive therapy to avoid tuberculosis reactivation.
Is COVID-19 multisystem inflammatory syndrome a new variant of Kawasaki Disease?
Authors: Abu Hammour Khawla , Abu Farha Rana , Manaseer Qusai , Dawoud Tasnim , Abu Hammour Walid 
Published: December 2021

Objectives: In this systematic review, we aimed to evaluate the clinical features, therapeutic options, and outcomes of children with multisystem inflammatory syndrome in children (MIS-C) and to investigate whether MIS-C is a new variant of Kawasaki disease.
Materials and methods: Adhering to PRISMA principles, we searched for eligible studies between December 2019 and June 2020 through the following databases: PubMed, ISI Web of Science, SCOPUS, and Science Direct. Studies including original data of patients aged <21 years with MIS-C and descriptions of clinical signs, laboratory or radiological investigations were selected.
Results: A total of 84 studies were identified, for which 48 were eligible for full screening and only 13 studies (n=657) met our inclusion criteria. More than 70% of patients with MIS-C tested positive for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). The most common symptoms were gastrointestinal (80 to 100%) and most patients presented with fever for >4 days. Mucocutaneous manifestations are similar to Kawasaki disease presented in up to 64% in some studies. Almost all patients had significant elevations in inflammatory markers, and up to 50 to 100% had elevated troponin suggesting myocardial damage. Intravenous immunoglobulin (IVIG) was administered to 60% of patients in 12 studies and 80 to 100% in five studies. Steroids were administered to 10 to 95% of patients. The overall mortality rate was 0.9%.
Conclusion: The temporal association between novel coronavirus disease 2019 (COVID-19) onset and Kawasaki-like disease and MIS-C suggests a causal link. Both syndromes have similar cascades of symptoms and hyperinflammation, which likely explain their response to the same immunomodulatory agents. However, it is unclear yet why some children appear more susceptible to develop MIS-C.
LncRNA cardiac autophagy inhibitory factor is downregulated in rheumatoid arthritis and suppresses the apoptosis of fibroblast-like synoviocytes by promoting the maturation of miRNA-20a
Authors: Xu Dongming , Lin Ling , Chen Zhen 
Published: December 2021

Objectives: In this study, we aimed to investigate the effects of LncRNA cardiac autophagy inhibitory factor (CAIF) and miR-20a on the apoptosis of synovial cells in rheumatoid arthritis (RA) and the regulatory mechanism.
Patients and methods: Between May 2018 and March 2020, a total of 62 RA patients (24 males, 38 females; mean age: 55.2±4.9 years; range, 42 to 68 years) and 62 controls (24 males, 38 females; mean age: 55.3±4.8 years; range, 41 to 68 years) were included in this study. Plasma samples were collected from all participants. The expression levels of CAIF, mature miR-20a, and miR-20a precursor in these plasma samples were determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Correlations were analyzed using linear regression analysis. Overexpression of CAIF was achieved in human fibroblast-like synoviocytes (HFLSs) and the expression levels of mature miR-20a and miR-20a precursor were determined using RT-qPCR. Cell apoptosis was analyzed by cell apoptosis assay.
Results: The CAIF was downregulated in RA and positively correlated with the expression of mature miR-20a. In HFLSs, LPS treatment resulted in downregulation of both CAIF and miR-20a in a dose-dependent manner. In HFLSs, overexpression of CAIF did not affect the expression of miR-20a precursor, but upregulated the expression of mature miR-20a. Cell apoptosis analysis showed that overexpression of CAIF and miR-20a inhibited the apoptosis of HFLSs induced by LPS. The combination of overexpression of CAIF and miR-20a showed a stronger effect.
Conclusion: The CAIF may suppress the apoptosis of HFLSs in RA by promoting the maturation of miR-20a.
Implementation of Reciprocal Teaching Strategies: Improving Reading Skills and Academic Performance of Secondary Students
Authors: Dadabhoy Kiran , Dadabhoy Marium 
Published: December 2021

Proficiency in reading comprehension is very important especially for secondary English language students. In this mixed methods study, the research proven methodological intervention “reciprocal teaching” is introduced to improve the reading skills and academic performance of 30 secondary students of grade 11. Reciprocal teaching is a scaffold dialogue technique that is built upon four strategies which competent readers use to understand text namely predicting, questioning, clarifying and summarizing. The four strategies of reciprocal teaching were each part of the four interrelated cycles that comprised the related activities implemented during the intervention. A general plan inclusive of activities, teaching resources, observation schedules, checklists and assessments was constructed and used for data collection. When the scores of pre and post assessments were compared using paired samples t test, they showed a significant amount of improvement in grades of students as well as their ability to effectively understand the text. The outcomes proved reciprocal teaching to be a significant technique for improving reading comprehension skills and academic performance. In addition, the implication for teachers who teach reading comprehension is that through modeling and implementation of the reciprocal strategies like predicting, clarifying, questioning and summarizing they can enhance the academic performance of students.
Penggunaan Aplikasi Canva Untuk Pembelajaran Ilmu Pengetahuan Sosial Kelas VI di SDN 02 Tarantang
Authors: Putri Revina Junia , Mudinillah Adam 
Published: December 2021

Khusus di SD-SMP-SMA/SMK pembelajaran ilmu pengetahuan sosial ini adalah pelajaran yang harus ada ikut masing-masing tingkatan pendidikan. Pendidikan ilmu pengetahuan sosial adalah suatu bentuk sederhana atau olahan dari pengetahuan sosial dan humanisme, dan juga suatu bentuk tindakan dasar manusia yang di wadahi dan di sampaikan secara faktual dan psikologis atau pedagogi untuk tujuan pendidikan.Untuk pelajaran IPS ini pasti sudah banyak yang megetahuinya bahwa pelajaran ini membahas tentang materi hafalan yang mana sering kali dapat mambuat siswa merasa bosan. Maka dari itu akan lebih baik dan menarik jika untuk pembelajaran ilmu pengetahuan sosial kelas vi tema sub tema 2 pembelajaran 1 di sdn 02 tarantang menngunakan aplikasi Canva. Pada masa pendemi Covid 19 ini sangat banyak mendatangkan perubahan baru didalam kehidupan manusia pada saat ini termaksud dalam dunia pendidikan. Metode penelitian yang digunakan penelitian yang di modifikasi menjadi empat tingkat sebagai berikut kajian awalan, pengenalan entitas, pembuatan produksi, dan percobaan. Belajar dengan menggunakan yang namanya tidak tatap muka atau daring adalah suatu bentuk hal baru didalam dunia pendidikan maupun bagi mahasisswa diperguruan tinggi di Indonesia, khususnya bagi mahasiswa untuk dapat menyesuaikan dengan keperluan atau kebutuhan pengajaran di kelas seperti, membuat sebuah video presentase yang menarik. Oleh karena itu, untuk memenuhi kebutuhan tersebut pendidik bisa menggunakan aplikasi canva. Penggunaan aplikasi canva untuk pembelajaran pada ilmu pengetahuan sosial mendukung untuk meningkatkan ketertarikan siswa dalam proses belajar, salah satu aplikasi yang naik daun yaitu canva yang banyak di gunakan, aplikasi tersebut berukuran kurang lebih 24 MB dan dapat di download dengan gratis tetapi memang ada beberapa vitur di dalamnya yang tidak tersedia dengan gratis. Meskipun demikian, aplikasi tersebut tetap worth it digunakan editor media pembelajaran online.
ORTAOKUL ÖĞRENCİLERİNİN YAZDIĞI ÖYKÜLEYİCİ METİNLERİN EĞİTSEL İLETİLER AÇISINDAN İNCELENMESİ
Authors: ŞEN Erhan , ÖBÜZ Ekrem 
Published: December 2021

Bu araştırmanın amacı ortaokul öğrencilerinin yazdığı öyküleyici metinleri eğitsel iletiler açısından incelemektir. Bu çalışmada verilerin toplanması için doküman incelemesi yönteminden, verilerin çözümlenmesi için de içerik analizinden yararlanılmıştır. Çalışmaya Siirt ili Merkez 80.Yıl Ortaokulunda öğrenim gören 125 ortaokul öğrencisi katılmıştır. Bu öğrencilerin ürettiği 125 öyküleyici metin de çalışmanın veri kaynağını oluşturmaktadır.
Çalışmada ortaokul öğrencilerinin yazdığı öykülerin çözümlenmesi için farklı bir araştırmacı tarafından hazırlanmış bir kod listesinden yararlanılmıştır. Araştırma sonucunda ortaokul öğrencilerinin oluşturduğu öyküleyici metinlerde toplamda 358 eğitsel ileti belirlenmiştir. Ortaokul öğrencilerinin yazdığı öyküleyici metinlerde en fazla psikolojik iletilere (f: 277) yer verildiği görülmektedir. Bunu da sıklık düzeyi açısından sırasıyla sosyolojik iletiler (f: 61) ekonomik iletiler (f: 15 ve etik iletiler (f: 5) izlemektedir. Bu bulguların birçok çalışmanın sonuçlarıyla örtüştüğü tespit edilmiştir. Bunun dışında ortaokul öğrencilerinin yazdığı öyküleyici metinlerdeki eğitsel iletilerin Türkçe Dersi Öğretim Programında (2019) dikkat çekilen kök değerleri içerdiği ve “Değerlerimiz” temasıyla da uyumlu bir nitelik sergilediği görülmüştür.
Lighting design: a creative, technological and collaborative pursuit
Authors: Dwyer Simon 
Published: December 2021

The lighting design is often the most compromised element of a theatrical production as it is traditionally the last of many designs to be realised before opening night. Lighting, however, is vital because without artistic lighting, a production, regardless of how ingeniously and skilfully it is devised, will remain, if not in literal, then at least in figurative darkness. The lighting design is also the aspect of a production most constrained by time: the script lies waiting to be redeployed or re-imagined; the director’s notes are archived or reused; sets and costumes are put on display or into storage; sound is remixed or replayed; and the actors are photographed for advertising and programmes. In sharp contrast light is cued, it illuminates, and then it is gone. The creative processes that underpin lighting designs are changing. This paper highlights some of the technological changes the discipline has witnessed over recent years to provide an overview of the praxis of lighting designer’s craft and, in the context of these innovations, to ask how this has impacted upon creative processes. Are lighting designers more, or less, creative as tools become increasingly advanced? Does conflict between traditional and modern approaches to lighting facilitate a new type of creativity?
Social creativity at the coalface: a heuristic case study incorporating non-human agency
Authors: Holmes Ashley M 
Published: December 2021

The safe operation of an underground coal mine is coordinated in a control room where data from a range of sensory equipment, and indeed, all communication between underground personnel and the surface, is monitored. It is here that response to any emergency is initiated. Specific hazard management plans and emergency procedures will be triggered by any one of a number of automatic or manual alarms. The complex array of information to be processed has the potential to overwhelm the cognitive capacity of the control room operator, particularly in a potentially catastrophic emergency scenario. A proprietary computer software-based system (Nexsys™) uses a rules engine to assist with real time monitoring and response affording control via a single interface. This paper arises from the experience of a designer charged with proposing a user interface design at a specific site, enabling efficient monitoring of prevalent operational conditions and prioritised, context-relevant access to technical documents, procedures and communications. It is a reflective case study account that draws on trans-disciplinary literature in order to theorise the nature of the creativity involved in implementing a user centered design approach. The heuristic analysis, from the perspective of a creative industry practitioner working in an industrial situation not commonly associated with creativity, proposes that Csikszentmihalyi’s (1999) “systems perspective for the study of creativity” be appended to include non-human agency before a convincing account of the sources of creativity involved may be proposed.
Supporting creativity in architectural education: examining the impact of leadership, management and staff development
Authors: Williams Anthony , Ostwald Michael J 
Published: December 2021

Universities in Australasia, as they drive curriculum innovation, face a range of challenges that inhibit their momentum. A number of these challenges have arisen in response to the federal government’s compliance monitoring entities, which are focussed on academic standards and quality assurance. In addition to this, there is an increased emphasis on research performance, innovation and postgraduate education. Against this backdrop, the present paper examines academic leadership, management and staff development and considers the implications of these overarching processes for supporting creativity (and associated curriculum innovation) in architectural education. Through surveys, interviews and focus groups, with leaders in architecture and design schools across Australasia, this paper provides a critical review of their attitudes and concerns. As part of this study, eleven recurring themes are identified as being relevant to leadership and management issues. These include workload, skills, management, support, health and succession planning. In combination these themes effectively articulate the pressures and concerns of academic leaders. In light of these findings, this paper considers the impact of these leadership and management issues on curriculum initiatives that have the potential to advance and build creativity in contemporary architectural education. The paper concludes that the situation, as revealed through the study, does not auger well for the future even though, through enhanced staff development, some potential exists for producing innovative curriculum structures and learning environments.
Effects of Aqueous Leaf Extract of Simarouba glauca DC (Simaroubaceae) on Lipoprotein Homeostasis and Oxidative Stress Biomarkers
Authors: Osagie-Eweka Sammydavies E. , Orhue Noghayin J. , Omogbai Eric I. 
Published: December 2021

Background and Purpose: Simarouba glauca is widely reported to contain a number of biologically active compounds with potentials in the treatment of numerous diseases. The study was conducted to evaluate the sub-acute effects of the aqueous leaf extract of Simarouba glauca (AESG) on lipoproteins and oxidative stress biomarkers in male Wistar rats.
Methods: Oral administration of AESG was carried out in line with the guidelines of the Organization for Economic Co-operation and Development (OECD), No. 425 using a total of 24 male Wistar rats allotted to four groups (n=6); given distilled water, 500, 1000, and 2000 mg/kg/day of AESG respectively for 30 days.
Results: In plasma, there was a significant reduction (P?0.05) in HDL-cholesterol; elevated (P?0.05) triglycerides (TG) at 1000 and 2000 mg/kg/day; elevated (P?0.05), and LDL-cholesterol at 500 and 1000 mg/kg/day, relative to the control. While the level of liver total cholesterol (TC) reduced significantly, it increased in the heart. Catalase (CAT) activity in the liver increased significantly (P?0.05) at all doses. The dose of 1000 mg/kg/day significantly (P?0.05) elevated kidney CAT activity. The activities of superoxide dismutase (SOD) in liver and heart reduced (P?0.05) at 500 mg/kg/day. At all doses, the levels of reduced glutathione (GSH) in plasma, liver and heart were comparable with the control. Although, there were no significant changes in plasma and liver glutathione peroxidase (GSH-PX) activity at all doses, animals given 500 mg/kg had reduction (P?0.05) in the heart GSH-PX activity compared to the control.
Conclusion: Oral sub-acute AESG at high doses altered lipid homeostasis in plasma and heart without lipid peroxidation or oxidative stress. The extract has the potential to cause hyperlipidemia.
مرحلة الحكم الخلقي السائدة لدى عينة من طلبة جامعة اليرموك وفقا لنظرية "رست" للنمو الخلقي
Authors: محمد فرحان,محمد عثمان  ,حاتم محمد القصاء،   المحيسي، الصمدي، 
Published: December 2021

مرحلة الحكم الخلقي السائدة لدى عينة من طلبة جامعة اليرموك وفقا لنظرية "رست" للنمو الخلقي
هدفت هذه الدراسة إلى التعرف على مرحلة الحكم الخلقي السائدة لدى عينة من طلبة جامعة اليرموك وفقا لنظرية رست للنمو الخلقي لدى عينة من طلبة جامعة اليرموك تبعا لاختلاف (الجنس و التخصص و المستوى الدراسي).
و قد تكونت عينة الدراسة من (765) طالبا و طالبة من جامعة اليرموك المسجلين للفصل الدراسي الثاني 2005 / 2006 و البالغ عددهم (19394) و تم اختيارهم بالطريقة الطبقية العشوائية.
و لأغراض تطبيق هذه الدراسة قام فريق البحث باستخدام أداة مقياس الحكم الخلقي لرست.
و لقد كشفت نتائج الدراسة بأن مرحلة الحكم الخلقي الرابعة قد جاءت في المرتبة الأولى ثم تلاها في المرحلة الثانية مرحلة الحكم الخلقي الثالثة، و كشفت نتائج الدراسة عن وجود فروق ذات دلالة إحصائية بيم مراحل الحكم الخلقي تعزى لاختلاف (جنس الطالب و تخصصه و مستواه الدراسي).
تقدير نموذج الاستيراد في السودان خلال الفترة 1960-2008م
Authors: عماد عمر أبكر أحمد 
Published: December 2021

تقدير نموذج الاستيراد في السودان خلال الفترة 1960-2008م
The research objectives are building, estimating and analyzing the model of import.
The research follows the analytical descriptive methodology and applies the econometrics approach.
The determinants included are: gross domestic production, investment, exchange rate and customs (tariff), regarding the simultaneous relationships between the variables.
The results shwed that individual estimators are significantly different from zero.
Also the import model is significantly different from zero.
The proportion of the total variation in the import explained by the model is 77%
Peningkatan Motivasi Belajar Matematika Melalui Discovery Learning Dengan Aplikasi Google Suite For Education
Authors: Wahyuni Sri 
Published: December 2021

Pembelajaran konvensional kurang mendukung motivasi belajar matematika siswa dimasa pandemi Covid-19. Tujuan penelitian ini untuk meningkatan motivasi belajar matematika melalui penerapan pembelajaran jarak jauh dengan discovery learning-google suite for education. Penelitian dilakukan di kelas VIII SMP Negeri 109 Jakarta semester genap tahun pelajaran 2019-2020 menggunakan Penelitian Tindakan Kelas yang terdiri dari perencanaan, pelaksanaan, pengamatan, refleksi. Berdasarkan analisis data ditemukan: 1) rata-rata motivasi belajar matematika pada siklus 1 = 73,17 meningkat menjadi 77,72 pada siklus 2, Peningkatan motivasi siswa tersebut meliputi; tekun dalam menghadapi tugas; ulet dalam menghadapi kesulitan; menunjukkan minat; senang bekerja mandiri; cepat bosan pada tugas-tugas rutin; dapat mempertahankan pendapat; tidak mudah melepas hal yang diyakini; senang mencari dan memecahkan masalah; 2) rata-rata aktivitas meningkat dari siklus1 = 83,4% menjadi 92,6% pada siklus 2, peningkatan aktivitas siswa tersebut meliputi: hadir tepat waktu; kumpulkan tugas tepat waktu; senang memecahkan soal; terlibat aktif; menyampaikan ide. Simpulan penelitian ini adalah melalui discovery learning-google suite for education dapat meningkatkan motivasi belajar dan aktivitas siswa pada pembelajaran matematika jarak jauh.
Penggunaan Know What Learned (K-W-L) Strategy untuk Meningkatkan Kemampuan Siswa Membaca Report Text
Authors: Zulaikah Atik 
Published: December 2021

Penelitian ini bertujuan meningkatkan kemampuan membaca teks ilmiah dengan menggunakan Strategi K-W-L (Know-What-Learned) pada siswa SMA kelas XI IPA. Partisipan penelitian ini berjumlah 36 siswa dipilih menggunakan teknik purposive sampling. lnstrumen penelitian terdiri atas terdiri atas tes dan non-tes. Adapun instrumen tes berupa pilihan ganda yang berjumlah 20 item. Sedangkan instrumen non-tes lembar pengamatan. Prosedur pengumpulan data melalui pemberian tes tertulis dan pengamatan. Prosedur analisis data berdasarkan siklus (di setiap akhir siklus). Temuan penelitian menunjukkan bahwa hasil tes tentang kemampuan menulis siswa diperoleh nilai rata-rata siklus I sebesar 74,14 hasil rata-rata siklus II sebesar 83,06 hasil tersebut menunjukkan kenaikan sebesar 8,92 point dari siswa yang tuntas belajar pada siklus I 66,65% dan pada siklus II siswa yang tuntas belajar sebesar 83,32% terjadi kenaikan sebesar 16,67% berarti hasil belajar siswa dapat meningkat, dengan menggunakan strategi pembelajaran K-W-L. Hasil dari kedua siklus ini didukung oleh data hasil pengamatan selama proses penelitian berlangsung. Berdasarkan hasil penelitian tersebut dapat disimpulkan bahwa strategi K-W-L dapat meningkatkan hasil belajar siswa pada Aspek Membaca Report Text.