bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementasi Metode Profile Matching Pada Penjurusan Bidang Minat Siswa (Studi kasus di SMA 12 Semarang)
Authors: Muljono Muljono , Permatasari Wulanda Yuniar 
Published: December 2021

Siswa kelas X SMA belum dapat menentukan bidang minat apa yang harus mereka pilih disebabkan oleh pengetahuan yang kurang. Meskipun kepala sekolah serta guru telah memberikan pengarahan pada siswa, namun tidak sepenuhnya memberikan solusi masalah yang dihadapi siswa kelas X SMA. Selain itu sekolah juga dituntut untuk terus saling bersaing untuk memiliki kualitas siswa yang baik dan memajukan kualitas sekolah, sehingga sistem atau teknologi yang mendukung penjurusan juga harus diadakan untuk mendukung akreditas sekolahan. Kemampuan penalaran berbasis kemiripan data atau profile matching adalah salah satu elemen utama pada sistem berbasis pengetahuan. Kemampuan pada sistem berbasis pengetahuan mampu mendefinisikan kemiripan dengan sangat baik. Hasil percobaan yang dilakukan perhitungan profile matching dapat memberikan perbandingan, pada peminatan kelas IPA siswa sebanyak 192 hanya 84% saja yang positif bisa masuk. Sedangkan jika peminatan kelas IPS seluruh siswa sebanyak 192 semuanya bisa masuk. Sehingga dengan adanya sistem yang diterapkan dengan metode Profile Matching ini akan dapat membantu sekaligus menjadi tambahan dukungan dalam siswa SMA kelas X yang ingin mendaftar peminatan sekolah
Effect of pH Variation on Cross-Linking of Water-Soluble and Acid-
Soluble Chitosan with Sodium Tripolyphosphate and Gallium-67
Authors: Alishahi Alireza , Heidarieh Marzieh , Kamali Narjes D. , Rajabifar Saeed , Mirsadeghi Hojat , Kordjazi Moazame 
Published: December 2021

Background:
Chitosan is a cationic biopolymer obtained from deacetylating chitin, a natural compound present in crustacean shell, fungi and exoskeleton of insects. Chitosan involves various applications, including as drug and gene delivery systems, as wound dressing material and scaffolds for tissue engineering, agriculture, textile, food and feed nanotechnology, and in wastewater treatments. Chitosan-TPP particle has been figured out as the most important and sta-ble nanoparticle for chitosan application in various fields.

Objective:
In this study, chitosan was chemically modified by sodium tripolyphosphate (TPP). Af-terward, TPP-chitosan was radiolabeled with the gallium-67 radionuclide. The effect of several factors on labeling yield, such as chitosan solubility, acidity and concentration of TPP-chitosan so-lution, and incubation time with gallium-67, were investigated.

Methods:
To prepare [67Ga] gallium-chitosan complex, chitosan (0.5 ml) was dissolved in 2.2 mCi of [67Ga] gallium chloride solution. The obtained solution was stirred for 5 min and then kept for 30 min at room temperature. The radiochemical purity and radiolabeling yield were measured via radiochromatography, which was performed by using a radio thin-layer chromatography (TLC) scanner instrument. To investigate the effect of chitosan kind and concentration on the labeling yield, two kinds of chitosan (acid-soluble chitosan and water-soluble chitosan) at two different concentrations (1% and 0.5%) and different pH were used. In addition, labeling efficiency and sta-bility of the 67Ga-TPP-chitosan complex (acidic/water soluble chitosan) at both concentrations (0.5 and 1%) and at room temperature were assessed for 30, 45 and 60 min.

Results:
The incubation time did not have any significant effect on labeling yield. The acidic solu-ble chitosan exhibited the highest radiolabeling yield at pH=9.3-10.4, while water-soluble chitosan showed the highest radiolabeling yield at pH > 5. Also, the prepared complex was stable in the fi-nal solution at room temperature and could even be used 24 hours after preparation for further ap-plication.

Conclusion:
Taken together, the TPP-modified water-soluble chitosan at the concentration of 0.5 % depicted the highest radiochemical yield (>95 %) in the optimized condition (pH= 6.2–7.6). Therefore, TPP modified water-soluble chitosan can prove to be an effective carrier for therapeutic radionuclides in tumor treatment.
Health System Strategies and Adolescent Sexual Health: A Systematic Review of the Literature using Rodgers Concept Analysis Framework
Authors: Nunu Wilfred Njabulo , Makhado Lufuno , Mabunda Jabu Tsakani , Lebese Rachel Tsakani 
Published: December 2021

Background:
Health Systems Strategies play a key role in determining Adolescent Sexual Health outcomes. This study aims to review the literature on the relationship between Health Systems Strategies and Adolescent Sexual Health issues guided by Rodger's evolutionary concept analysis framework. The study further develops a Conceptual Framework that would guide a study that seeks to “Develop strategies to facilitate safe sexual practices in adolescents through Integrated Health Systems in selected Districts in Zimbabwe.”

Methods:
Adolescents, Health Systems, Sexual Health, and Strategies were used to search for published literature (in English) on Google Scholar, PUBMED, EBSCO, Cochran Library, and Science Direct. A total of 142 Articles and 11 reports were obtained, and the content was screened for relevance. This led to 42 articles and 03 reports being found suitable and relevant, and thus, the content was reviewed. Thematic analysis was done to identify attributes, antecedents, and consequences of Health Systems Strategies on Adolescent Sexual Health. These findings were then used to inform the development of the Conceptual Framework.

Results:
Key attributes, antecedents and consequences of Health System Strategies on Adolescent Sexual Health were identified. Strategies to Improve Adolescent Sexual Health outcomes were also identified.

Conclusions:
Different contextual factors influence policy changes and the consequences are mixed, with both positive and negative outcomes.
Peptide Functionalised Nanocarriers for Bone Specific Delivery of PTH (1-34) in Osteoporosis
Authors: Salave Sagar , Rana Dhwani , Benival Derajram 
Published: December 2021

:
Osteoporosis represents a major public health burden especially considering the aging population worldwide. Treatment modalities for osteoporosis are classified into two categories based on the effect on bone remodelling: anabolic drugs and antiresorptive drugs. Anabolic drugs are preferred as it stimulates new bone formation. Currently, PTH (1-34) is the only peptide-based drug approved as an anabolic agent for the treatment of osteoporosis by both USFDA as well as EMA. However, its non-specific delivery results in prolonged kidney exposure, causing hypercalcemia. Nanotechnology-based drug delivery systems functionalized by conjugating it with homing moieties, such as peptides, offer an advantage of targeted delivery with reduced off-target effects. Here, we propose an innovative and targeted nanovesicle approach to efficiently deliver PTH (1-34) to the bone surface using peptides as a homing moiety. The proposed innovative delivery approach will augment the specific interaction between the drug and bone surface without producing side effects. This will reduce the off-target effects of PTH (1-34), and at the same time, it will also improve the outcome of anabolic therapy. Therefore, we postulate that the proposed innovative drug delivery approach for PTH (1-34) will establish as a promising therapy for osteoporotic patients, specifically in postmenopausal women who are at greater risk of bone fracture.
Antidiabetic Potential of Silver/Chitosan/Ascorbic Acid Nanocomposites
Authors: Abu El Qassem Mahmoud Esraa Ahmed , Mohamed Ayman S , Fahmy Sohair R. , Soliman Amel Mahmoud , Gaafar Khadiga 
Published: December 2021

Background:
Diabetes mellitus is the most common health problem in the world. Silver nanoparticles (AgNPs) exposed great intrinsic anti-inflammatory, antibacterial, antiviral, and antifungal activities. Chitosan is an oligosaccharide biopolymer with a great ability to lower hyperglycemia, and ascorbic acid is a water-soluble vitamin with strong antioxidant activity.

Objective:
The present study aimed to estimate AgNPs/chitosan/ascorbic acid nanocomposite (Ag-NCs) anti-diabetic properties in streptozotocin-induced diabetic rats.

Method:
Eighteen male Wistar albino rats were divided into three main groups (6 rats/group); control, diabetic, and Ag-NCs groups. Control group: after a single dose of citrate buffer at PH 4.5 (0.1 mol/L, i.p), the rats orally received 1 ml distilled water daily for four weeks. The diabetic model was induced by a single dose of streptozotocin (60 mg/kg, i.p) for type 1 diabetes and the rats orally received 1 ml distilled water daily for four weeks. The diabetic group was treated orally with Ag-NCs (0.25 mg/Kg body weight) daily for four weeks.

Results:
AgNPs/chitosan/ascorbic acid nanocomposite group showed a reduction in the concentrations of glucose, NO, MDA, LDL, and the activities of AST, ALT, ALP, and GGT. At the same time, it caused a general increase in insulin, albumin, TB, TC, TG, HDL, CAT, SOD, and GSH levels. The histopathological investigation illustrated regeneration of damaged pancreatic beta cells and a clear improvement in the hepatic architecture.

Conclusion:
The suggested mechanism of action for Ag-NCs in decreasing diabetic complications in the liver involved two pathways; the hypoglycemic activity and the antioxidant role of AgNPs, chitosan, and ascorbic acid.
Charting the Information and Misinformation Landscape to Characterize Misinfodemics on Social Media: COVID-19 Infodemiology Study at a Planetary Scale
Authors: Chen Emily , Jiang Julie , Chang Ho-Chun Herbert , Muric Goran , Ferrara Emilio 
Published: December 2021

Background
The novel coronavirus, also known as SARS-CoV-2, has come to define much of our lives since the beginning of 2020. During this time, countries around the world imposed lockdowns and social distancing measures. The physical movements of people ground to a halt, while their online interactions increased as they turned to engaging with each other virtually. As the means of communication shifted online, information consumption also shifted online. Governing authorities and health agencies have intentionally shifted their focus to use social media and online platforms to spread factual and timely information. However, this has also opened the gate for misinformation, contributing to and accelerating the phenomenon of misinfodemics.

Objective
We carried out an analysis of Twitter discourse on over 1 billion tweets related to COVID-19 over a year to identify and investigate prevalent misinformation narratives and trends. We also aimed to describe the Twitter audience that is more susceptible to health-related misinformation and the network mechanisms driving misinfodemics.

Methods
We leveraged a data set that we collected and made public, which contained over 1 billion tweets related to COVID-19 between January 2020 and April 2021. We created a subset of this larger data set by isolating tweets that included URLs with domains that had been identified by Media Bias/Fact Check as being prone to questionable and misinformation content. By leveraging clustering and topic modeling techniques, we identified major narratives, including health misinformation and conspiracies, which were present within this subset of tweets.

Results
Our focus was on a subset of 12,689,165 tweets that we determined were representative of COVID-19 misinformation narratives in our full data set. When analyzing tweets that shared content from domains known to be questionable or that promoted misinformation, we found that a few key misinformation narratives emerged about hydroxychloroquine and alternative medicines, US officials and governing agencies, and COVID-19 prevention measures. We further analyzed the misinformation retweet network and found that users who shared both questionable and conspiracy-related content were clustered more closely in the network than others, supporting the hypothesis that echo chambers can contribute to the spread of health misinfodemics.

Conclusions
We presented a summary and analysis of the major misinformation discourse surrounding COVID-19 and those who promoted and engaged with it. While misinformation is not limited to social media platforms, we hope that our insights, particularly pertaining to health-related emergencies, will help pave the way for computational infodemiology to inform health surveillance and interventions.
The Pilgrimage Concept in the Caribbean?
Authors: Hayward Michele , Cinquino Michael , Schieppati Frank , Smith Donald 
Published: December 2021

Espenshade (2014) has argued that pre-Columbian major ballcourts/plazas on Puerto Rico, particularly with rock art, could be considered special religious places. He proposes that these precincts were being transformed from locations of communal social and ceremonial activities integrating diverse population segments to increasingly restricted-to-religious functions as shrines or pilgrimage centers serving a greatly reduced local population by the end of the pre-colonial period. The extent of incorporation of pre-colonial late phase plazas into a formal pilgrimage round for the Puerto Rico island will be examined employing archaeological data from both the Greater and Lesser Antilles. We conclude that while Espenshade’s particular argument for enclosures-as-pilgrimage sites may or may not be appropriate, simply raising the issue prompts a wider consideration of the region’s ritual structure involving rock art and non-rock art sites.
Objeciones al sistema interamericano de protección de derechos humanos
Authors: Manrique Jorge Isaac Torres 
Published: December 2021

Acerca del mismo, es preciso dejar constancia de dos puntos neurálgicos a abordarse. En primer lugar, los excesivos tiempos que toma la Corte IDH para resolver los casos bajo su jurisdicción, así como, para ejecutar las mismas, en los términos dispuestos por la misma.
Ello, en el marco de la paradoja que se presenta entre la quintaesencia de la SIDH, CIDH y Corte IDH, para controlar y asegurar la salvaguarda de los derechos fundamentales y el objetivo desempeño de sus funciones, que va en contra de la propia naturaleza de la que fueron concebidos y puestos en vigencia.
The state of biogenic monoamine metabolism and processes of their oxidative deamination in patients with gastrocancerogenesis
Authors: I. M. Vasylieva  , E. A. Shevchenko  , Yu. A. Vinnyk  , V. I. Zhukov  , A. S. Tkachenko  
Published: December 2021

Biogenic monoamines metabolism and activity of oxidative deamination and their prognostic significance were investigated in patients with gastrocarcinogenesis. Investigation showed dynamic changes in serum levels of biogenic monoamines and activity of platelet MAO-B. Serum dopamine, epinephrine, norepinephrine, DOPA levels decreased, respectively, for II, III and IV stages of gastric cancer. An increase of serotonin and monoamine oxidase activity was observed. Analysis of obtained data showed inhibition of ergotropic body functions, activation of trophotropic processes and processes of biogenic amines deamination were observed in gastric cancer, which might be one of the major reasons for the accumulation of serum ammonia, aldehydes and peroxides-oxidizing agents and endotoxins.
Optimization of a hip replacement technology
Authors: Y. M. Vasylchyshyn  
Published: December 2021

A new cemented hip prosthesis was designed and clinically probed which takes into consideration the neckshaft angle variability. Femoral component with inclination angle of 125° was implanted in 22,64 % of patients, with angle 135° in 62,26 % cases, and 145° in 15,09 %. Follow-up results in 160 cases divided into three clinical groups showed mean Harris hip score in main group 84,94±2,28, whereas in two control groups 85,49±1,55 and 82,39±2,56. No statistically significant difference was found; however, mean age in the main clinical group was higher than in the control groups by 9,99 years and by 10,65 years, respectively (p<0,05). Therefore, regardless the fact that mean Harris hip score showed no significant difference in the three clinical groups while mean age in the main group was 10 years higher than in the control groups, conclusion about superiority of the designed prosthesis received indirect confirmation.
Effective application of Quercetin as a maintenance therapy for complete denture in patients with type ii diabetes
Authors: O. O. Maksymiv  
Published: December 2021

The efficacy of using Quercetin as maintenance therapy in complete dentures for prevention of inflammatory and degenerative disorders. High efficiency of the proposed preventive measures concerning the preparation of the mucous membrane in patients with diabetes type ІІ has been approved. Application of Quercetin combined in enteral and topical manner (application on the tissue of the prosthetic bed) significantly reduces the clinical manifestations of inflammation, leading to the restoration of the balance of oxidant-antioxidation system and, on the effectiveness of the above conventional enteral administration. Given the fact that the effect of therapeutic measures is unstable and get reduced by some values within 6 months after the treatment twice a year, the patients in this category are indicated repeated courses.
Leptinemia, parameters of heart rate variability, and prognosis in patients with essential arterial hypertension with obesity
Authors: O. Radchenko  , N. Bek  , V. Potapov  
Published: December 2021

An examination of 103 patients with essential hypertension and obesity showed the dependence of autonomic cardioregulation, electrical ventricular systole, and prediction of adverse cardiovascular events on the serum leptin concentration (hyper-, normo – or hypoleptinemia).
Some aspects of stable angina treatment: risk of complications assessment in a combined course with COPD
Authors: V. K. Tashchuk  , T. N. Amelinа  , A. S. Polianska  , О. I. Hulaga  
Published: December 2021

The effect of carvedilol on indices of pulmonary ventilation in patients with stable angina in combination with chronic obstructive pulmonary disease and the expediency of its function during stable remission comorbidity has been studied.
Correction of blood aggregation disturbances in girls with uterine bleedings at the age of puberty
Authors: A. H. Khodan  
Published: December 2021

We have studied the effect of combined treatment with the use of Arnica montana tincture and mefenamic acid on the characteristics of platelet-vascular and general hemocoagulation potential of the blood, system of fibrinolysis and eicosanoid regulation of primary hemostasis in girls with uterine bleedings at the age of puberty. The implementation of our scheme of combined treatment of girls with anovulatory uterine bleedings at the age of puberty, accelerates regression of disease symptoms, reduces the duration and intensity of bleeding and reduces the duration of treatment.
Plasma proteolytic and fibrinolytic activity in non-alcoholic steatohepatitis, combined with chronic obstructive pulmonary disease
Authors: T. P. Tsyntar  
Published: December 2021

The study involved 30 patients with NASH, 30 patients with chronic obstructive pulmonary disease and 30 patients with non-alcoholic steatohepatitis in combination with chronic obstructive pulmonary disease. A substantial enhancement of proteolysis low and high molecular weight proteins, of colagenolytic activity of plasma and nonenzymatic fibrinolysis against reduction of content of α2-macroglobulin in serum and more pronounced decrease in activity of the enzymatic fibrinolysis in this combined pathology.
A case of successful swyer syndrome treatment in two sisters
Authors: L. I. Sehediy  
Published: December 2021

A case of successful Swyer syndrome treatment in two sisters has been described. Phenotypically both patients were women with 46, XY karyotype. Anamnesis: primary amenorrhea and infertility in both cases, an USG scan revealed decrease in size of the uterus and ovaries, laboratory findings: essentially elevated concentration of gonatropins in the blood serum. Laparoscopic gonadectomy has been performed. Hormone replacement therapy has been administered, regular period has developed in both patients under the received hormone replacement therapy. Infertility treatment was provided by an egg donor IVF cycle. The fact of a singleton and twin pregnancies occurrence which resulted respectively in one mature and two premature children confirms effectiveness of the applied treatment method.
University Educational-Practical Centres of the primary medical care – a step to the improvement of the family doctors training
Authors: Sydorchuk L. P. , Biletskyi S. V. , Petrynych O. A. , Ivashchuk S. I. , Kazantseva T. V. , Mel’nychuk L. V. , Nykyfor L. V. , Sokolenko A. A. , Flyundra I. G. 
Published: December 2021

The information about the University Educational-Practical Centres of the primary medical care of Bukovinian State Medical University and the peculiarities of the teaching process in present conditions is given.
論胚胎的道德地位——儒家倫理的視角
Authors: SHEN Xiuqin , PAN Feng 
Published: December 2021

LANGUAGE NOTE | Document text in Chinese; abstract also in English.
For 40 years, international rules have limited human embryo research to the first 14 days of embryonic development. On May 26, 2021, in its latest guidelines for stem cell research and its medical applications, the International Society for Stem Cell Research eased the 14-day restriction. This raises myriad ethical issues. At their core is the debate over the moral status of embryos, which exposes ethical conflicts between cultural perspectives. This article discusses the moral status of embryos and argues from the perspective of Confucian ethics that the 14-day limit should not be waived at the present moment.
論人體胚胎研究“軟法”修改之正當性
Authors: DING Chunyan 
Published: December 2021

LANGUAGE NOTE | Document text in Chinese; abstract also in English.
This commentary briefly discusses the substantive and procedural justifications for amending the longstanding 14-day rule, a soft-law limitation on the culturing of human embryos. The 14-day rule was established on the basis of general recognition of the human embryo's special status, accompanied by widespread public conversation and engagement. In principle, amending this rule would require the same substantive and procedural justifications. However, such justifications were absent prior to the lifting of the rule by the ISSCR in its 2021 guidelines. This article also discusses the value and importance of the 14-day rule to the development of human embryo research in the last three decades. Discarding the rule without the proper substantive and procedural justifications is likely to damage public trust and confidence in future human embryo research.
人類自然的身體性狀是不應被技術改造的嗎？
Authors: LIU Yue Shu 
Published: December 2021

LANGUAGE NOTE | Document text in Chinese; abstract also in English.
Human beings always try to transcend their limitations. Emerging technologies provide a set of powerful tools that promise to significantly improve human performance, stimulating the desire of some technical experts to transform the human body. Against this backdrop, superhumanism has come into being in today's society and is flourishing. Superhumanism has been criticized by some Chinese scholars on the basis of traditional Chinese thought. Their criticism of superhumanism is a difficult task that involves multi-level reflection on human nature, technology, and value. I argue that for the issue of superhumanism, theoretical innovation is more important than continuing to invoke traditional thought.