bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular Disease Risk in Calcium Pyrophosphate Deposition Disease: A Nationwide Study of Veterans
Authors: Bashir Maaman , Sherman Katherine A. , Solomon Daniel H. , Rosenthal Ann , Tedeschi Sara K. 
Published: September 2021

ObjectiveCalcium pyrophosphate deposition (CPPD) disease represents a common crystalline arthritis with a range of manifestations. Our goal was to investigate risks for cardiovascular events in patients with CPPD.MethodsWe performed a retrospective matched cohort analysis in the Veterans Health Administration Corporate Data Warehouse, 2010–2014. CPPD was defined by ≥1 International Classification of Diseases, Ninth Revision codes for chondrocalcinosis or calcium metabolism disorder. CPPD patients were age‐ and sex‐matched to approximately 4 patients without codes for CPPD; we excluded patients with a cardiovascular event during the 365 days prior to the index date. Demographic information, traditional cardiovascular risk factors, medications, and health care utilization were assessed at baseline. The primary outcome was a major adverse cardiovascular event (MACE: myocardial infarction, acute coronary syndrome, coronary revascularization, stroke, or death). Secondary outcomes included individual components of MACE. Cox proportional hazards models estimated fully adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs).ResultsWe identified 23,124 CPPD patients matched to 86,629 non‐CPPD patients with >250,000 person‐years of follow‐up. The study population was 96% male, mean age was 78 years, and 75% were White. The frequency of traditional cardiovascular risk factors was similar between the 2 cohorts. CPPD was not significantly associated with risk for MACE (HR 0.98 [95% CI 0.94–1.02]) in fully adjusted models, though risks of myocardial infarction, acute coronary syndrome, and stroke were significantly higher in the CPPD cohort compared to the non‐CPPD cohort.ConclusionCPPD did not confer an increased risk for MACE, a composite end point including all‐cause mortality. Our results propose CPPD as a novel risk factor for MACE components, including myocardial infarction, acute coronary syndrome, and stroke.
Patient Empowerment and Associations with Disease Activity and Pain‐Related and Lifestyle Factors in Patients With Rheumatoid Arthritis
Authors: Larsson Ingrid , Bremander Ann , Andersson Maria 
Published: September 2021

BackgroundEmpowerment is important to patients with rheumatoid arthritis (RA) because most care is in the form of self‐management. The aim was to study levels of empowerment and associated variables in patients with RA and to investigate longitudinal clinical data in patients with low and high empowerment.MethodsA postal survey was sent in 2017 to patients with RA from the BARFOT (Better Anti‐Rheumatic Pharmacotherapy) cohort that included questions about disease activity, pain‐related factors, lifestyle habits, and contained the Swedish Rheumatic Disease Empowerment Scale (SWE‐RES‐23). The 844 patients who answered the SWE‐RES‐23 made up the cohort of the present study. Differences in level of empowerment between groups (low, moderate, and high empowerment) were analyzed with ANOVA. Logistic regression analysis was used to study variables associated with low empowerment. Thirdly, we performed comparisons in longitudinal data (15 years) of disease activity, pain, and physical function between the three empowerment groups (low, moderate, and high empowerment).ResultsPatients with low empowerment (n = 282) were significantly older, more often women, and reported worse pain‐related factors and physical function and lower moderate and vigorous physical activity compared with those with high empowerment (n = 270). An analysis of longitudinal data found that patients with low empowerment had worse pain and physical function at all time points.ConclusionPatients with low empowerment have more pain‐related symptoms, poorer physical function, and are less physically active. To promote patient empowerment in rehabilitation interventions it is important to identify and support self‐management.
High‐Performance Solution‐Processed Nondoped Circularly Polarized OLEDs with Chiral Triptycene Scaffold‐Based TADF Emitters Realizing Over 20% External Quantum Efficiency
Authors: Wang Yin‐Feng , Li Meng , Teng Jin‐Ming , Zhou He‐Ye , Chen Chuan‐Feng 
Published: September 2021

AbstractRecently, circularly polarized organic light‐emitting diodes (CP‐OLEDs) fabricated with thermally activated delayed fluorescence (TADF) emitters are developed rapidly. However, most devices are fabricated by vacuum deposition technology, and developing efficient solution‐processed CP‐OLEDs, especially nondoped devices, is still a challenge. Herein, a pair of triptycene‐based enantiomers, (S,S)‐/(R,R)‐TpAc‐TRZ, are synthesized. The novel chiral triptycene scaffold of enantiomers avoids their intermolecular π–π stacking, which is conducive to their aggregation‐induced emission characteristics and high photoluminescence quantum yield of 85% in the solid state. Moreover, the triptycene‐based enantiomers exhibit efficient TADF activities with a small singlet‐triplet energy gap (ΔEST) of 0.03 eV and delayed fluorescence lifetime of 1.1 µs, as well as intense circularly polarized luminescence with dissymmetry factors (|gPL|) of about 1.9 × 10−3. The solution‐processed nondoped CP‐OLEDs based on (S,S)‐/(R,R)‐TpAc‐TRZ not only display obvious circularly polarized electroluminescence signals with gEL values of +1.5 × 10−3 and −2.0 × 10−3, respectively, but also achieve high efficiencies with external quantum, current, and power efficiency up to 25.5%, 88.6 cd A−1, and 95.9 lm W−1, respectively.
Low‐Cost and Large‐Area Hybrid X‐Ray Detectors Combining Direct Perovskite Semiconductor and Indirect Scintillator
Authors: Li Weijun , Liu Lulu , Tan Mingrui , He Yuhong , Guo Chunjie , Zhang Huimao , Wei Haotong , Yang Bai 
Published: September 2021

AbstractBoth semiconductors and scintillators have their own advantages in direct and indirect X‐ray detection, respectively. However, they are also limited by their intrinsic properties and detection mechanisms. Here, a low‐cost and large‐area flat X‐ray detector is reported by combining a cesium silver bismuth bromide (Cs2AgBiBr6) perovskite semiconductor with a ethylenebis‐triphenylphosphonium manganese (II) bromide ((C38H34P2)MnBr4) scintillator through fast tableting processes. Cs2AgBiBr6 and (C38H34P2)MnBr4 can attenuate the X‐ray photons to induce charge carriers that are collected through the continuous Cs2AgBiBr6 grains. (C38H34P2)MnBr4 blocks the Cs2AgBiBr6 ions migration paths at the grain boundaries to reduce the device dark current/noise and improves the working stability. Most charges generated by (C38H34P2)MnBr4 are transferred to the adjacent Cs2AgBiBr6, and recombined charges radiate light through scintillation, which will be further absorbed by the surrounding Cs2AgBiBr6 perovskite, and further induce collectable charges for indirect X‐ray detection, avoiding the unwanted light scattering, self‐absorption, or afterglow effects of scintillators. The hybrid X‐ray detector displays a high sensitivity of 114 µC Gyair−1 cm−2 to 120 keVp hard X‐rays with a lowest detectable dose rate of 0.2 μGyair s−1, showing 75 times lower detection limit compared to (C38H34P2)MnBr4 scintillator, which provides a new path for X‐ray flat‐panel design.
3D Printing of Black Bioceramic Scaffolds with Micro/Nanostructure for Bone Tumor‐Induced Tissue Therapy
Authors: Wang Xin , Liu Yin , Zhang Meng , Zhai Dong , Wang Yufeng , Zhuang Hui , Ma Bing , Qu Yu , Yu Xiaopeng , Ma Jingge , Ma Hongshi , Yao Qingqiang , Wu Chengtie 
Published: September 2021

AbstractIt is common to improve the relevant performance in the field of energy storage materials or catalytic materials by regulating the number of defects. However, there are few studies on the biomaterials containing defects for tissue engineering. Herein, a new type of defect‐rich scaffolds, black akermanite (B‐AKT) bioceramic scaffolds with micro/nanostructure, the thickness of which is from 0.14 to 1.94 µm, is fabricated through introducing defects on the surface of bioceramic scaffolds. The B‐AKT scaffolds have advantages on the degradation rate and the osteogenic capacity over the AKT (Ca2MgSi2O7) scaffolds due to the surface defects which stimulate the osteogenic differentiation of rabbit bone mesenchymal stem cells via activating bone morphogenetic protein 2 （BMP2） signaling pathway and further promote bone formation in vivo. In addition, the prepared B‐AKT scaffolds, the temperature of which can be over 100 °C under the near infrared （NIR） irradiation (0.66 W cm−2), possess excellent performance on photothermal and antitumor effects. The work develops an introducing‐defect strategy for regulating the biological performance of bioceramic scaffolds, which is expected to be applied in the next generation of bioceramic scaffolds for regenerative medicine.
High‐Temperature Nitridation Induced Carbon Nanotubes@NiFe‐Layered‐Double‐Hydroxide Nanosheets Taking as an Oxygen Evolution Reaction Electrocatalyst for CO2 Electroreduction
Authors: Chen Hao , Zhang Ping , Xie Ruishi , Xiong Ying , Jia Chunhui , Fu Yingke , Song Pingan , Chen Lin , Zhang Yaping , Liao Ting 
Published: September 2021

AbstractThe development of high‐efficiency catalysts for carbon dioxide reduction reaction (CO2RR) and oxygen evolution reactions (OER) is an important strategy to solve the current energy crisis. In this paper, solid‐phase exfoliation and electrostatic self‐assembly strategies are developed to couple ultrathin NiFe‐layered‐double‐hydroxide nanosheets and carbon nanotubes (CNT@NiFe‐LDH NS) as an OER catalyst. Then, NiFe nanoparticles anchored on the N‐doped CNT (CNT‐N‐NiFe) for electrocatalyst of CO2RR is synthesized via pyrolysis of a mixture of CNT@NiFe‐LDH NS and melamine in a nitrogen atmosphere at 750 °C, utilizing the ultrathin NiFe‐LDH NS as a metal source and CNT as the framework. CNT@NiFe‐LDH NS nanohybrid exhibits a better catalytic activity for OER (with an overpotential of 270 mV at the current density of 20 mA cm–2 and remarkably stable durability) than Bulk NiFe‐LDH in 1 m KOH. Moreover, the CNT‐N‐NiFe catalyst exhibits a Faradaic efficiency of ≈82.6% for the reduction of CO2 to CO at −0.7 V (vs reversible hydrogen electrode) with a current density of CO 10.2 mA cm–2. The method of preparing CO2RR catalysts provides a new idea of the preparation of bimetallic CO2RR electrocatalysts.
Highly Sensitive and Fast Responsive Humidity Sensor based on 2D PtSe2with Gamma Radiation Tolerance
Authors: Mondal Shuvra , Min Bok Ki , Yi Yoonsik , Choi Choon‐Gi 
Published: September 2021

Abstract2D transition‐metal dichalcogenides (TMDs) with their unique properties have accelerated the study of emerging sensors and nanoelectronics to embed in various industries including severe environments such as nuclear power plant, low Earth orbit, and space. Therefore, a systematic investigation of the sensing properties and ionizing radiation effect on 2D TMDs is required. This study reveals a facile humidity sensor based on 2D platinum diselenide (PtSe2), and the effect of a high dose of gamma (γ‐ray) radiation on their physical and electrical properties. The proposed humidity sensor exhibits notable variation of current signal up to 105orders under the relative humidity (RH) range of 20–85% and a fast response time of 60 ms. The real‐time electrical output of the PtSe2during irradiation by 10 kGy of γ‐rays (60Co), followed by material characterization confirms their unique stability under gamma radiation. Furthermore, precise and fast detection of moisture by the proposed PtSe2‐based humidity sensor is demonstrated as a potential leak locator application.
Magnetic Levitation Type Double Helix Self‐Powered Acceleration Sensor Based on ZnO‐RTV Film
Authors: Mu Jiliang , Han Xiaotao , Yu Junbin , Song Jinsha , He Jian , Geng Wenping , Zou Jie , Xian Shuai , Chou Xiujian 
Published: September 2021

AbstractTraditional accelerometers rely on batteries to provide energy, and the massive use of batteries caused great pressure on the natural environment. In this paper, a self‐powered acceleration sensor is designed. To more easily harvest weak vibration signals and effectively improve the sensitivity, this sensor is built on a magnetic levitation type double helix structure and ZnO‐doped triboelectric film. Experiments indicated that the open‐circuit voltage and short circuit current of the triboelectric nanogenerator (TENG) doped with ZnO are increased by 2.51 times and 2.07 times, respectively. Under shaking table test for simulating machine vibration environment, the sensor's sensitivity reaches 16.31 V (m s−2)−1 and its linearity is 0.993. The sensor power generation is 110 μW and its test range is ≈1–7 m s−2. Also, the sensor can be applied for monitoring human's movement state by installing in a sole. This design provides a new idea for the development of TENG‐based sensors.
Sonoporation: Past, Present, and Future
Authors: Rich Joseph , Tian Zhenhua , Huang Tony Jun 
Published: September 2021

AbstractA surge of research in intracellular delivery technologies is underway with the increased innovations in cell‐based therapies and cell reprogramming. Particularly, physical cell membrane permeabilization techniques are highlighted as the leading technologies because of their unique features, including versatility, independence of cargo properties, and high‐throughput delivery that is critical for providing the desired cell quantity for cell‐based therapies. Amongst the physical permeabilization methods, sonoporation holds great promise and demonstrates to deliver a variety of functional cargos, such as biomolecular drugs, proteins, and plasmids, to various cells including cancer, immune, and stem cells. However, traditional bubble‐based sonoporation methods usually require special contrast agents. Bubble‐based sonoporation methods also have high chances of inducing irreversible damage to critical cell components, lowering the cell viability, and reducing the effectiveness of delivered cargos. To overcome these limitations, several novel non‐bubble‐based sonoporation mechanisms are under development. This review will cover both the bubble‐based and non‐bubble‐based sonoporation mechanisms being employed for intracellular delivery, the technologies being investigated to overcome the limitations of traditional platforms, as well as perspectives on the future sonoporation mechanisms, technologies, and applications.
Carbonitridation Pyrolysis Synthesis of Prussian Blue Analog‐Derived Carbon Hybrids for Lithium‐Ion Batteries
Authors: Wang Yisha , Chen Ruixuan , Ang Edison Huixiang , Yan Yan , Ding Ying , Ke Longwei , Luo Yan , Rui Kun , Lin Huijuan , Zhu Jixin 
Published: September 2021

AbstractCost‐effective nanostructured carbon hybrids have received global attention in sustainable energy research due to their stable structure and high conductivity. Herein, the nickel‐cobalt nanoparticles embedded carbon nanotube hybrid (NCCH) derived from Prussian blue analogs (PBAs) has been prepared by a carbonitridation pyrolysis process. Simultaneously, the uniform NCCHs interweave to form a conductive structure. The fascinating architecture offers abundant active sites and enhanced electronic conductivity when served as an anode material in lithium‐ion batteries. As a consequence, the resulting NCCH exhibits excellent cell behaviors with a high reversible capacity and remarkable rate capability. Equally important, the study provides a unique insight into the development of high‐performance carbon hybrids electrodes derived from PBAs.
Synergistic Texturing and Bi/Sb‐Te Antisite Doping Secure High Thermoelectric Performance in Bi0.5Sb1.5Te3‐Based Thin Films
Authors: Tan Ming , Shi Xiao‐Lei , Liu Wei‐Di , Li Meng , Wang Yaling , Li Hui , Deng Yuan , Chen Zhi‐Gang 
Published: September 2021

AbstractBi2Te3‐based thin films are attracting increasing attention due to their considerable wearability and flexibility feature. However, the relatively low performance compared to their bulk counterparts limits their development and wider application. In this work, synergistic texturing and Bi/Sb‐Te antisite doping are used to achieve a high room‐temperature ZT of ≈1.5 in p‐type Bi0.5Sb1.5Te3 thin films by a magnetron sputtering method. Structural characterization confirms that carefully tuning the deposition temperature can strengthen the texture of as‐prepared polycrystalline Bi0.5Sb1.5Te3 thin films, leading to significantly enhanced carrier mobility and electrical conductivity. Simultaneously, rational engineering of the deposition temperature can induce antisite doping between Bi/Sb and Te, which can reduce the carrier concentration and make it closer to the optimized level. In turn, a high power factor of 45.3 µW cm−1 K−2 and a maximized ZT of ≈1.5 at room temperature are obtained. This high power factor and ZT are highly competitive to other state‐of‐the‐art p‐type thin‐film‐based thermoelectric materials, showing great potentials for practical applications.
Genetic and phenotypic heterogeneity in KIAA0753‐related ciliopathies
Authors: Inskeep Katherine A. , Zarate Yuri A. , Monteil Danielle , Spranger Jurgen , Doherty Dan , Stottmann Rolf W. , Weaver K. Nicole 
Published: September 2021

AbstractPrimary ciliopathies are heterogenous disorders resulting from perturbations in primary cilia form and/or function. Primary cilia are cellular organelles which mediate key signaling pathways during development, such as the sonic hedgehog (SHH) pathway which is required for neuroepithelium and central nervous system development. Joubert syndrome is a primary ciliopathy characterized by cerebellar/brain stem malformation, hypotonia, and developmental delays. At least 35 genes are associated with Joubert syndrome, including the gene KIAA0753, which is part of a complex required for primary ciliogenesis. The phenotypic spectrum associated with biallelic pathogenic variants in KIAA0753 is broad and not well‐characterized. We describe four individuals with biallelic pathogenic KIAA0753 variants, including five novel variants. We report in vitro results assessing the function of each variant indicating that mutant proteins are not fully competent to promote primary ciliogenesis. Ablation of KIAA0753 in vitro blocks primary ciliogenesis and SHH pathway activity. Correspondingly, KIAA0753 patient fibroblasts have a deficit in primary ciliation and improper SHH and WNT signaling, with a particularly blunted response to SHH pathway stimulation. Our work expands the phenotypic spectrum of KIAA0753 ciliopathies and demonstrates the utility of patient‐focused functional assays for proving causality of genetic variants.
Deciphering the Mechanisms of Electrochemiluminescence by Spatially Resolved Measurements
Authors: Wang Yafeng , Su Bin 
Published: September 2021

AbstractElucidating the mechanisms of electrochemiluminescence (ECL) generation is crucial for developing novel ECL systems, designing new luminophores and coreactants, and expanding the application of ECL in different fields. Diverse methods have been developed so far for this purpose, among which spatially resolved measurements using ECL microscopy (ECLM), scanning electrochemical microscopy (SECM) and ECL self‐interference spectroscopy (ECLIS), are particularly valuable in terms of their ability to measure the distribution of excited luminophores and coreactant radicals. This review aims to provide an overview of research progress on deciphering the mechanisms of ECL by spatially resolved measurements. The reaction pathways for ECL generation are briefly introduced and then the advances in understanding the mechanisms of ECL reaction in solutions and on the surface of microbeads are summarized. A personal perspective covering both mechanisms and challenges is finally presented.
Study molecular modeling and the effect of some biological metals on the efficiency of norfloxacin in presence of 3‐(bromoacetyl)coumarin
Authors: El‐Shwiniy Walaa H. , Gamil Manar A. , Sadeek Sadeek A. , Zordok Wael A. 
Published: September 2021

AbstractA series of new mixed ligand metal complexes of Mn(II), Fe(II), Co(II), Ni(II), Cu(II), and Zn(II) have been synthesized by the reaction of norfloxacin (NOR) with 3‐(bromoacetyl)coumarin (BAC) in 1:1:1 (Mn+:NOR:BAC) molar ratio, which characterized by elemental analysis, spectroscopic measurements (FT‐IR, UV–Vis) molar conductance, effective magnetic moments, and thermogravimetric analysis (TG) and (DTG). All the complexes soluble in DMSO and the conductivity measurement indicate that the complexes are electrolyte with ratio 1:1 for Mn(II), Fe(II), and Zn(II) and 1:2 for Co(II), Ni(II), and Cu(II). Electronic and magnetic data elucidated the octahedral structure for all complexes. Assorted thermodynamic factors are calculated, and the results are explicated. Molecular modeling calculations (bond angles, dihedral angles, total energy, heat of formation, and dipole moment) confirm the structural geometry of the complexes and indicate the very good agreement between the computed and experimental geometrical parameters. The calculated data for the hardness (η) and absolute softness (σ) showed that all complexes are soft with respect to ligands. The two ligands and their metal complexes have also been screened for their antibacterial and antifungal activity against some selected species; the data showed that the complexes have remarkable potency as compared with the parent ligands.
Convenient Unsymmetrical Disulfane Synthesis: Basic Zeolite‐Catalyzed Thiol‐Disulfane Exchange Reaction
Authors: Yamamoto Eiji , Kawai Yasutaka , Takakura Kei , Kimura Moemi , Murayama Haruno , Matsueda Hironobu , Otsuki Shujiro , Sakata Hiroshi , Tokunaga Makoto 
Published: September 2021

AbstractConvenient catalytic synthetic methods for the preparation of unsymmetrical disulfanes are described. Na‐exchanged X type zeolite (Na‐X), commercially available as MS‐13X, effectively catalyzes thiol‐disulfane exchange reactions with 1.0 equivalent of thiols and 2.5–3.0 equivalents of disulfanes at 10 °C to room temperature under air. The reactions of sterically‐hindered disulfanes or electron‐deficient thiol substrates require high temperatures under inert atmospheres to maintain the good product yields. Various functionalized thiols and disulfanes are tolerant in the present catalytic systems, affording the corresponding unsymmetrical disulfanes in good‐to‐high yields (up to 96 %). The Na‐X catalyst was successfully recycled 10 times without loss of yield. Preliminary mechanistic studies suggest the involvement of base‐catalyzed SN2‐S displacement and/or addition‐elimination mechanisms, assisted by hydrogen‐bonding interactions.