bluuebunny/crossref_metadata_2025_split huggingface dataset:
PELATIHAN PENGGUNAAN EJAAN YANG DISEMPURNAKAN DAN KALIMAT EFEKTIF PADA PENULISAN SURAT RESMI BAGI KURSUS BINTANG MULIA BATU BARA DESA PEMATANG RAMBAI KECAMATAN NIBUNG HANGUS KABUPATEN BATU BARA
Authors: Maulina Azmi Sri Rezki , Dewi Muthia , Akmal Akmal 
Published: February 2021

Abstrack: Indonesian for the Indonesian nation is the language of unity. Indonesian is also a communication tool for all Indonesian people. Therefore, Indonesian language learning is devoted to improving the ability of students to communicate using Indonesian language properly and correctly verbally or in writing. The community service activity entitled "Training on the Use of Enhanced Spelling and Effective Sentences on Writing Official Letters for the Bintang Mulia Coal Course in Pematang Rambai Village, Nibung Hangus District, Batu Bara District" aims to train students in the Guidance for Bintang Mulia Coal Village Pematang Rambai properly and correctly. The method used in this conventional activity is material exposure, discussion, and practice. The speaker conducts explanations about the use of improved spellings and arguments effectively in writing official letters. Keywords: Use of Enhanced Spelling and effective sentences on official letter writing Abstrak: Bahasa Indonesia bagi bangsa Indonesia adalah bahasa persatuan. Bahasa Indonesia juga sebagai alat komunikasi bagi seluruh rakyat Indonesia. Oleh karena itu, pembelajaran bahasa Indonesia dikhususkan untuk meningkatkan kemampuan peserta didik agar berkomunikasi menggunakan bahasa Indonesia dengan baik dan benar secara lisan maupun tulis. Kegiatan pengabdian kepada masyarakat yang diberi judul “Pelatihan Penggunaan Ejaan Yang Disempurnakan Dan Kalimat Efektif Pada Penulisan Surat Resmi Bagi Kursus Bintang Mulia Batu Bara Desa Pematang Rambai Kecamatan Nibung Hangus Kabupaten Batu Bara” bertujuan untuk melatih peserta didik yang ada padabimbingan kursus Bintang Mulia Batu Bara Desa Pematang Rambai dengan baik dan benar. Metode yang digunakan dalam kegiatan ini konvensional yaitu paparan materi, diskusi, dan latihan. Pemateri melakukan penjelasan-penjelasan tentang penggunaan ejaan yang disempurnakan dan dalimat efektifpada penulisan surat resmi. Kata kunci: Penggunaan Ejaan Yang Disempurnakan dan kalimat efektif pada Penulisan surat resmi
PELATIHAN PUBLIC SPEAKING BERBASIS TEKNOLOGI INFORMASI DI KELURAHAN JOHAR BARU
Authors: Safitri Dini 
Published: February 2021

Abstract: This community service aims to empower people who are members of the Yasayan Senyum Ibu Indonesia (YSII), so that they dare to appear to do public speaking. Empowerment needs to be done, considering the number of Foundation activities that require public speaking skills. The empowerment method used in this service has three stages. The first stage is to introduce and teach participants, how to find material or material to be delivered in public speaking, using the internet. After the material is obtained, they are asked to arrange the sentences that will be delivered in public speaking, then practice them one by one. The second method is to teach and practice the participants to hear a lot while memorizing the words that have been heard, to be memorized and repeated. This method is the basic method of public speaking, which relies a lot on memory, based on what is heard, then memorized. After memorizing, recited in public speaking activities. The third method is one by one the participants learn to recite flat voice intonation, as a basic technique in public speaking. The results of this service are public speaking modules that will be made HKI, popular articles in online media, and scientific articles in public service journals. Keywords: Public Speaking, Internet, Information Technology Abstrak: Pengabdian ini bertujuan untuk memberdayakan masyarakat yang tergabung dalam Yasayan Senyum Ibu Indonesia (YSII), agar berani tampil untuk melakukan public speaking. Pemberdayaan ini perlu dilakukan, mengingat banyaknya kegiatan Yayasan yang memerlukan keterampilan public speaking. Metode pemberdayaan yang digunakan dalam pengabdian ini ada tiga tahap. Tahap pertama, adalah mengenalkan dan mengajarkan kepada para peserta, cara mencari bahan atau materi yang akan disampaikan dalam public speaking, dengan menggunakan internet. Setelah bahan di dapatkan, mereka diminta untuk menyusun kalimat yang akan disampaikan di dalam public speaking, kemudian mempraktikannya satu-persatu. Metode kedua adalah mengajarkan dan mempraktikan kepada para peserta untuk banyak mendengar sekaligus menghafalkan kata-kata yang telah didengar, untuk dihapalkan dan diulang kembali. Metode ini adalah metode dasar public speaking, yang banyak mengandalkan daya ingat, berdasarkan dari apa yang didengar, kemudian dihapalkan. Setelah hapal, dilafalkan dalam kegiatan public speaking. Metode ketiga adalah satu persatu peserta belajar melafalkan intonasi suara datar, sebagai teknik dasar dalam public speaking. Hasil dari kegiatan pengabdian ini adalah modul public speaking yang akan dibuat HKI, artikel popular di media online, adan artikel ilmiah di jurnal pengadian masyarakat. Kata Kunci: Public Speaking, Internet, Teknologi informasi
PELATIHAN APLIKASI MICROSOFT OFFICE 2010 DAN INTERNET UNTUK PARA SISWA DAN TUTOR PADA LEMBAGA KURSUS PENDIDIKAN (LKP) MANDIRI COMPUTER KABUPATEN ASAHAN SUMATERA UTARA
Authors: Siagian Yessica , Hutahaean Jeperson , Azhar Zulfi 
Published: February 2021

Abstract: STMIK Royal Kisaran Community Service Team (PKM) provided training to students of Asahan Regency Mandiri Computer Education Course (LKP), because they saw that there were still many school children and residents around the village who were still very limited in knowledge of computer technology and its applications around the village. there is no nearest computer course. The training material taught at the Mandiri Computer Institute of Training and Education (LKP) is office administration using Microsoft Office 2010 application programs, especially Word, Excel, Power Point and the Internet. Implementation is done by direct practice accompanied by presentations and discussions and using computers to provide direct understanding to students LKP. Keywords: Computer, Institutions Educational Courses,Microsoft Office 2010, Training, Students Abstrak: Tim Pengabdian kepada masyarakat (PKM) STMIK Royal Kisaran memberikan pelatihan kepada siswa Lembaga Kursus Pendidikan (LKP) Mandiri Computer Kabupaten Asahan, karena memandang masih banyaknya anak sekolah dan penduduk disekitar desa tersebut yang masih sangat minim pengetahuan tentang teknologi komputer beserta aplikasinya dimana disekitar desa tersebut belum ada tempat kursus komputer yang terdekat. Materi pelatihan yang diajarkan di Lembaga Kursus dan Pelatihan (LKP) Mandiri Computer yaitu administrasi perkantoran dengan menggunakan program aplikasi Microsoft Office 2010 khususnya Word, Excel, Power Point dan Internet. Pelaksanaan dilakukan dengan cara praktek langsung disertai dengan presentasi dan diskusi dan menggunakan komputer untuk memberikan pemahaman langsung kepada siswa LKP. Kata kunci: Komputer, Lembaga Kursus Pendidikan, Microsoft Office 2010, Pelatihan,Siswa
PELATIHAN BLOG SEBAGAI SARANA PUBLIKASI PEMBELAJARAN GURU SMA NEGERI 2 KISARAN
Authors: Maha  Putra Guntur , Irawati Novica , Prijuna Adi 
Published: February 2021

Abstract: As a formal education institution, acculturation of techniques in Teaching and Learning Activities (KBM) is required by each lesson teacher to be able to transfer knowledge to students maximal and optimally. So far the teaching carried out by the teachers of SMA 2 Kisaran is more dominant in learning done face-to-face in the classroom, so that learning requires the mind and energy that is extra because it is done repeatedly in the classroom and the hours that different. Starting from the above, the dedication team sought solutions so that teaching can be acculturated by online learning using blog media to publish teachers' teaching materials to the internet. It is expected that online-based teaching techniques, one of which is outlined in the making and utilization of blogs can stimulate interest from students to access teaching materials that have been published online, both in the form of text, images, audio and learning videos that have been recorded and uploaded by the teacher into his blog whenever and wherever it is, so that it will create student centered learning and learning objectives can be achieved. Keywords: blogs, teaching materials, online publications, videos, student center learning. Abstrak: Sebagai institusi pendidikan formal maka diperlukan akulturasi teknik dalam Kegiatan Belajar Mengajar (KBM) yang dilakukan oleh masing-masing guru pelajaran untuk dapat mentransfer ilmu pengetahuan kepada peserta didik secara maksimal dan optimal. Selama ini pengajaran yang dilakukan oleh guru-guru SMA Negeri 2 Kisaran lebih dominan ke-pembelajaran yang dilakukan secara tatap muka di dalam kelas, sehingga pembelajaran membutuhkan pikiran dan tenaga yang ekstra karena dilakukan secara berulang-ulang pada kelas dan jam yang berbeda. Berawal dari hal diatas maka tim pengabdian mencari solusi agar pengajaran dapat diakulturasi dengan pembelajaran secara online menggunakan media blog untuk mempublikasikan bahar ajar para guru ke internet. Diharapkan dengan teknik pengajaran berbasis online salah satunya yang dituangkan dalam pembuatan dan pemanfaatan blog dapat merangsang minat dari para siswa untuk mengakses bahan ajar yang telah dipublikasikan secara online baik informasi berupa text, gambar, audio maupun video pembelajaran yang telah direkam dan diupload oleh guru ke dalam blognya kapan dan dimanapun berada, sehingga akan tercipta pembelajaran berpusat pada siswa (Student Centred Learning) dan tujuan pembelajaran dapat tercapai. Kata kunci: blog, bahan ajar, publikasi online, video, Student Center Learning.
INTERNET SEHAT DAN AMAN (INSAN)
Authors: Nasution Donni , Rahayu Elly , Rohminatin Rohminatin 
Published: February 2021

Abstract: This service activity is carried out in the form of workshop where health and safe Internet became it's theme which was aimed to increasing the knowledge of women, especially the women of Bhayangkari Polsek Porsea in using the internet in a healthy and safe manner. The target audience of this Service Program are 20 women from bhayangkari Polsek Porsea. The method used are the lecture method, direct discussion and also question and answer. The material provided includes such as Women in the Technological Era, Empowering Women through Internet Technology, and also Healthy and Safe Internet. The benefits obtained from this service are the first is to improve current knowledge of technology for the women, the second is to increase the knowledge of the women roles in technology and the third is to educate the internet ethics and its benefits for herself and the family, children especially. Keywords: Insan, health and safe, Women, Internet Abstrak: Kegiatan pengabdian ini dilaksanakan dalam bentuk kegiatan Workhshop yang bertemakan Internet sehat dan aman yang bertujuan meningkatkan pengetahuan perempuan khususnya ibu-ibu Bhayangkari dalam menggunakan internet secara sehat dan aman. Khalayak sasaran dalam kegiatan Pengabdian kepada Masyarakat ini adalah Ibu-Ibu bhayangkari yang berjumlah 20 orang. Metode yang digunakan adalah metode ceramah, diskusi dan tanya jawab secara langsung. Materi yang diberikan diantaranya seperti Perempuan di Era Teknologi, Pemberdayaan Perempuan Melalui Teknologi Internet, serta Internet Sehat dan Aman. Manfaat yang diperoleh dari kegiatan pengabdian ini pertama meningkatkan pengetahuan. Teknologi masa kini kepada perempuan, kedua meningkkat pengetahuan tentang peran perempuan dalam Teknologi dan ketiga melakukan edukasi etika berinternet serta manfaat bagi dirinya dan keluarga, terutama kepada anak-anak. Kata kunci: Insan, Sehat dan Aman, Wanita, Internet
Association of Trimethylamine N-Oxide Levels and Calcification in Culprit Lesion Segments in Patients With ST-Segment–Elevation Myocardial Infarction Evaluated by Optical Coherence Tomography
Authors: Li Jiannan , Tan Yu , Zhou Peng , Liu Chen , Zhao Hanjun , Song Li , Zhou Jinying , Chen Runzhen , Wang Ying , Zhao Xiaoxiao , Chen Yi , Yan Hongbing 
Published: February 2021

The presence of calcified plaques is one of the pathological phenotypes of acute coronary syndrome (ACS) and can be frequently found in culprit lesion segments. Trimethylamine N-oxide (TMAO) is reported to be involved in vascular calcification and plaque instability. This study investigated the relationship between plasma TMAO levels and calcified lesions in culprit lesion segments in STEMI patients. A prospective series of 179 patients with STEMI were enrolled, and calcified lesions from 127 patients were analyzed by OCT. The plasma TMAO levels were measured by using stable isotope dilution liquid chromatography tandem mass spectrometry. Patients were divided into two groups according to the median plasma TMAO level. The prevalence of intimal calcified lesions in the high TMAO group was significantly higher than that in the low TMAO group (90.6 vs. 57.1%, p &lt; 0.001; 84.4 vs. 44.4%, p &lt; 0.001). After adjustment of traditional risk factors and medication history, patients with calcification in their culprit lesion segments had higher plasma TMAO levels than those without calcification. Moreover, plasma TMAO levels were significantly positively associated with the parameters of calcium burden, including maximal calcification arc (r = 0.392, p &lt; 0.001), maximal calcification thickness (r = 0.443, p &lt; 0.001), and calcified length (r = 0.466, p &lt; 0.001). These results suggested that the level of TMAO is significantly correlated with the incidence of calcification in the culprit lesion segment, and the measurement of TMAO levels might improve clinical management in patients with heavy calcification.Clinical Trial Registration: This study is registered at ClinicalTrials.gov as NCT03593928.
Gray Matter and Regional Brain Activity Abnormalities in Subclinical Hypothyroidism
Authors: Zhang Yang , Yang Yaqiong , Tao Bo , Lv Qingguo , Lui Su , He Li 
Published: February 2021

BackgroundSubclinical hypothyroidism (SCH) brain structure and resting state of functional activity have remained unexplored.PurposeTo investigate gray matter volume (GMV) and regional brain activity with the fractional amplitude of low-frequency fluctuations (fALFF) in subclinical hypothyroidism (SCH) patients before and after treatment.Material and MethodsWe enrolled 54 SCH and 41 age-, sex-, and education-matched controls. GMV and fALFF of SCH were compared with controls and between pre- and post-treatment within SCH group. Correlations of GMV and fALFF in SCH with thyroid function status and mood scales were assessed by multiple linear regression analysis.ResultsCompared to controls, GMV in SCH was significantly decreased in Orbital part of inferior frontal, superior frontal, pre-/postcentral, inferior occipital, and temporal pole gyrus. FALFF values in SCH were significantly increased in right angular, left middle frontal, and left superior frontal gyrus. After treatment, there were no significant changes in GMV and the local brain function compared to pre-treatment, however the GMV and fALFF of the defective brain areas were improved. Additionally, decreased values of fALFF in left middle frontal gyrus were correlated with increased mood scales.ConclusionIn this study we found that patients with SCH, the gray matter volume in some brain areas were significantly reduced, and regional brain activity was significantly increased. After treatment, the corresponding structural and functional deficiencies had a tendency for improvement. These changes may reveal the neurological mechanisms of mood disorder in SCH patients.
Identification and Validation of a Novel DNA Damage and DNA Repair Related Genes Based Signature for Colon Cancer Prognosis
Authors: Wang Xue-quan , Xu Shi-wen , Wang Wei , Piao Song-zhe , Mao Xin-li , Zhou Xian-bin , Wang Yi , Wu Wei-dan , Ye Li-ping , Li Shao-wei 
Published: February 2021

Backgrounds:Colorectal cancer (CRC) with high incidence, has the third highest mortality of tumors. DNA damage and repair influence a variety of tumors. However, the role of these genes in colon cancer prognosis has been less systematically investigated. Here, we aim to establish a corresponding prognostic signature providing new therapeutic opportunities for CRC.Method:After related genes were collected from GSEA, univariate Cox regression was performed to evaluate each gene’s prognostic relevance through the TCGA-COAD dataset. Stepwise COX regression was used to establish a risk prediction model through the training sets randomly separated from the TCGA cohort and validated in the remaining testing sets and two GEO datasets (GSE17538 and GSE38832). A 12-DNA-damage-and-repair-related gene-based signature able to classify COAD patients into high and low-risk groups was developed. The predictive ability of the risk model or nomogram were evaluated by different bioinformatics‐ methods. Gene functional enrichment analysis was performed to analyze the co-expressed genes of the risk-based genes.Result:A 12-gene based prognostic signature established within 160 significant survival-related genes from DNA damage and repair related gene sets performed well with an AUC of ROC 0.80 for 5 years in the TCGA-CODA dataset. The signature includes CCNB3, ISY1, CDC25C, SMC1B, MC1R, LSP1P4, RIN2, TPM1, ELL3, POLG, CD36, and NEK4. Kaplan-Meier survival curves showed that the prognosis of the risk status owns more significant differences than T, M, N, and stage prognostic parameters. A nomogram was constructed by LASSO regression analysis with T, M, N, age, and risk as prognostic parameters. ROC curve, C-index, Calibration analysis, and Decision Curve Analysis showed the risk module and nomogram performed best in years 1, 3, and 5. KEGG, GO, and GSEA enrichment analyses suggest the risk involved in a variety of important biological processes and well-known cancer-related pathways. These differences may be the key factors affecting the final prognosis.Conclusion:The established gene signature for CRC prognosis provides a new molecular tool for clinical evaluation of prognosis, individualized diagnosis, and treatment. Therapies based on targeted DNA damage and repair mechanisms may formulate more sensitive and potential chemotherapy regimens, thereby expanding treatment options and potentially improving the clinical outcome of CRC patients.
A Novel Method for Polyacrylamide Gel Preparation Using N-hydroxysuccinimide-acrylamide Ester to Study Cell-Extracellular Matrix Mechanical Interactions
Authors: Kumai Jun , Sasagawa Satoru , Horie Masanobu , Yui Yoshihiro 
Published: February 2021

Mechanical stimulation by the extracellular matrix (ECM) controls physiological and pathological cellular responses, such as stem cell differentiation, organogenesis, and tumor progression. Polyacrylamide (PA) gels have been widely used to study cell-ECM mechanical interactions. Typically, sulfosuccinimidyl 6-(4′-azido-2′-nitrophenylamino)hexanoate (sulfo-SANPAH) is used as a protein crosslinker in these gels. However, its low solubility, unstable binding with proteins, and high cost are barriers to its application. The objective of this study was to improve and simplify the preparation of PA gels using an economical crosslinker, N-hydroxysuccinimide-acrylamide (NHS-AA) ester, to enable increased stability in protein coating. By exposing excess NHS to the gel surface, we found an optimal ratio of NHS-AA ester:AA to obtain NHS-AA ester-containing PA gels with a uniform ECM protein coating and stiffness similar to that of sulfo-SANPAH-containing PA gels. The biological behavior of MCF7 and MCF10A cells were similar on NHS-AA ester and sulfo-SANPAH gels. Acini formation in Matrigel overlay culture were also consistent on NHS-AA ester and sulfo-SANPAH gels. This novel PA gel preparation method using NHS-AA ester can effectively replace the sulfo-SANPAH method and will be immensely useful in the evaluation of cell-ECM mechanical interactions.
Extracellular Vesicle-Associated miRNAs as a Biomarker for Lung Cancer in Liquid Biopsy
Authors: He Xue , Park Sujeong , Chen Yan , Lee Heedoo 
Published: February 2021

Extracellular vesicles are cell-derived membranous vesicles that are secreted into biofluids. Emerging evidence suggests that EVs play an essential role in the pathogenesis of many diseases by transferring proteins, genetic material, and small signaling molecules between cells. Among these molecules, microRNAs (miRNAs), a type of small noncoding RNA, are one of the most important signals and are involved in various biological processes. Lung cancer is one of the leading causes of cancer-related deaths worldwide. Early diagnosis of lung cancer may help to reduce mortality and increase the 5 years survival rate and thereby reduce the associated socioeconomic burden. In the past, EV-miRNAs have been recognized as biomarkers of several cancers to assist in diagnosis or prognosis. In this review, we discuss recent findings and clinical practice for EV-miRNAs of lung cancer in several biofluids, including blood, bronchoalveolar lavage fluid (BALF), and pleural lavage.
Changes in Patients’ Desired Control of Their Deep Brain Stimulation and Subjective Global Control Over the Course of Deep Brain Stimulation
Authors: Merner Amanda R. , Frazier Thomas , Ford Paul J. , Cooper Scott E. , Machado Andre , Lapin Brittany , Vitek Jerrold , Kubu Cynthia S. 
Published: February 2021

Objective: To examine changes in patients’ desired control of the deep brain stimulator (DBS) and perception of global life control throughout DBS.Methods: A consecutive cohort of 52 patients with Parkinson’s disease (PD) was recruited to participate in a prospective longitudinal study over three assessment points (pre-surgery, post-surgery months 3 and 6). Semi-structured interviews assessing participants’ desire for stimulation control and perception of global control were conducted at all three points. Qualitative data were coded using content analysis. Visual analog scales were embedded in the interviews to quantify participants’ perceptions of control over time.Results: Participants reported significant increases in their perception of global control over time and significant declines in their desired control of the stimulation. These changes were unrelated to improvements in motor symptoms. Improvements in global control were negatively correlated with a decline in desired stimulation control. Qualitative data indicate that participants have changed, nuanced levels of desired control over their stimulators. Increased global life control following DBS may be attributed to increased control over PD symptoms, increased ability to engage in valued activities, and increased overall self-regulation, while other domains related to global control remained unaffected by DBS.Conclusions: There are few empirical data documenting patients’ desire for stimulation control throughout neuromodulation and how stimulation control is related to other aspects of control despite the growing application of neuromodulation devices to treat a variety of disorders. Our data highlight distinctions in different types of control and have implications for the development of patient-controlled neurostimulation devices.