bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacts on Quality of Life with Escitalopram Monotherapy and Aripiprazole Augmentation in Patients with Major Depressive Disorder: A CAN-BIND Report
Authors: Morton Emma , Bhat Venkat , Giacobbe Peter , Lou Wendy , Michalak Erin E. , Chakrabarty Trisha , Frey Benicio N. , Milev Roumen V. , Müller Daniel J. , Parikh Sagar V. , Rotzinger Susan , Kennedy Sidney H. , Lam Raymond W. ,   on behalf of the CAN-BIND Investigator Team
Published: March 2021

ABSTRACT
Introduction Many individuals with major depressive disorder (MDD) do not respond to initial antidepressant monotherapy. Adjunctive aripiprazole is recommended for treatment non-response; however, the impacts on quality of life (QoL) for individuals who receive this second-line treatment strategy have not been described.
Methods We evaluated secondary QoL outcomes in patients with MDD (n=179). After 8 weeks of escitalopram, non-responders (<50% decrease in clinician-rated depression) were treated with adjunctive aripiprazole for 8 weeks (n=97); responders continued escitalopram (n=82). A repeated-measures ANOVA evaluated change in Quality of Life Enjoyment and Satisfaction Short Form scores. QoL was described relative to normative benchmarks.
Results Escitalopram responders experienced the most QoL improvements in the first treatment phase. For non-responders, QoL improved with a large effect during adjunctive aripiprazole treatment. At the endpoint, 47% of patients achieving symptomatic remission still had impaired QoL.
Discussion Individuals who were treated with adjunctive aripiprazole after non-response to escitalopram experienced improved QoL, but a substantial degree of QoL impairment persisted. Since QoL deficits may predict MDD recurrence, attention to ways to support this outcome is required.
Total Synthesis of Mycocyclosin and the Herqulines
Authors: Schindler Corinna S. , Ryan Jonathon S. 
Published: March 2021

AbstractSince the first reports of their isolation, mycocyclosin and the herquline family of natural products have attracted interest from the synthetic community for their uniquely strained macrocyclic architectures. This review describes the attempted and successful total syntheses of these natural products and provides a summary of the strategies developed in the years since their isolation.1	Introduction2	Biosynthesis3	Early Studies4	Total Synthesis of Mycocyclosin5	Overview6	Wood’s Total Syntheses of Herqulines B and C7	Baran’s Total Syntheses of Herqulines B and C8	Schindler’s Total Syntheses of Herqulines B and C9	Conclusions
Unlocking the Synthetic Potential of Light-Excited Aryl Ketones: Applications in Direct Photochemistry and Photoredox Catalysis
Authors: Dell’Amico Luca , Mateos Javier , Cuadros Sara , Vega-Peñaloza Alberto 
Published: March 2021

AbstractIn this Account, we summarize the contributions of our group to the field of photochemistry and photocatalysis. Our work deals with the development of novel synthetic methods based on the exploitation of photoexcited aryl ketones. The application of new technologies, such as microfluidic photoreactors (MFPs), has enhanced the synthetic performance and scalability of several photochemical methods, e.g., Paternò–Büchi and photoenolization/Diels–Alder processes, while opening the way to unprecedented reactivity. In addition, careful mechanistic analysis of the developed methods has been instrumental in disclosing a new family of powerful organic photocatalysts that can mediate several thermodynamically extreme photoredox processes.1	Introduction1.1	Shining Light on Aryl Ketones: From the Historical Background to Recent Synthetic Applications1.2	Preliminary Mechanistic Considerations2	Synthetic Transformations Driven by Triplet State Benzophenones3	Synthetic Transformations Driven by Triplet State o-Alkyl-Substituted Benzophenones4	The Evolution of Aryl-Ketone-Derived Products: Applications in Organophotoredox Catalysis5	Conclusions and Future Directions
The Multiple Rhomboid Vector Suture—Our Experience of Two Years with a Modified Suspension Approach for SMAS Plication Facelifts
Authors: Kaye Kai , Paprottka Felix , Kaestner Sonja , Gonser Phillipp 
Published: March 2021

AbstractPurse string sutures in superficial musculoaponeurotic system (SMAS) plication facelifts may cause technique-related problems, such as soft tissue deformities, dimpling, and bulkiness inside and between the independent sutures. Therefore, the authors have developed a new approach named the multiple rhomboid vector (MRV) suture. A total of 103 patients (89 female, 14 male patients; median age: 57 years) received a primary rhytidectomy with the MRV SMAS plication suture in our clinic (2015–2017). Intraoperative time to perform the suture per side was recorded. Postoperative complications and dimpling and bulkiness of subcutaneous tissues were judged by three independent surgeons from 1 (= none) to 4 (= extreme) after 1 week, 1, 3, 6, and 12 months. A standardized survey, the FACE-Q questionnaire, was performed to evaluate postoperative patient satisfaction. Mean time to perform the suture was 5:14 minutes per side (minimum: 3:20 minutes, maximum: 5:53 minutes; standard deviation: 0:51 minutes). During the follow-up period, four complications were detected (two cases of temporary neurapraxia of the marginal branch of the mandibular nerve {n = 2 [1.9%]} and two cases of retroauricular hematoma {n = 2 [1.9%]}). Postoperative dimpling or bulkiness of subcutaneous tissues was judged as absent. Overall patient satisfaction rate, after the surgery was performed, was measured as “very high.” The MRV suture offers a combined horizontal and vertical suspension approach, which effectively addresses the different vectors of age-related facial soft tissue descent with complication rates equal to other surgical lifting techniques. Apart from that, it may help reduce the possibility of contour irregularities, whereby it must be noted that a thorough preoperative assessment together with the patient and surgical planning is crucial to ensure realistic expectations of the surgical outcome.
Vitamin B12 Deficiency and West Syndrome: An Uncommon but Preventable Cause of Neurological Disorder. Report on Three Cases, One of Them with Late Onset during Vitamin B12 Treatment
Authors: Pavone Piero , Sullo Federica , Falsaperla Raffaele , Greco Filippo , Crespo Agustina , Calvo Agustin , Caraballo Roberto 
Published: March 2021

AbstractVitamin B12 is a water-soluble vitamin that plays a fundamental role as an essential cofactor for two enzymes responsible for the production of succinyl-CoA and methionine. Vitamin B12 deficiency can occur in infants and may be related to the breastfeeding mother's adherence to a vegan diet or somatic diseases in the mother. It should be differentiated from inborn errors of vitamin B12 metabolism. Herein, we report the cases of three infants with West syndrome; all three were breastfed by mothers who followed a strict vegan diet. In one of the three infants, West syndrome developed during treatment with vitamin B12 and normalization of the vitamin B12 level. Early treatment and replacement therapy are worthwhile to prevent serious neurological problems and to improve the patient's clinical course.
Complication Rates after Endoscopic Transsphenoidal Surgery for ACTH-Secreting Pituitary Adenomas: A Comparative Analysis with GH and Nonfunctioning Adenomas
Authors: Aibar-Durán Juan Á. , Oladotun-Anka Michael , Asencio-Cortés Carlos , Valassi Elena , Webb Susan , Gras-Cabrerizo Juan R. , Monserrat-Gili Joan , Ribó Pere Tresserras , Muñoz-Hernández Fernando 
Published: March 2021

Abstract
Objectives Some complications have been more frequently reported after surgery for adrenocorticotropin hormone (ACTH)-secreting pituitary adenomas. We compared complication rates in patients with ACTH-secreting pituitary adenomas with those in patients with growth hormone secreting pituitary adenomas (growth hormone [GH] group) and nonfunctioning adenomas (nonfunctioning group).
Design A comparative three-group analysis was performed for all patients who had endoscopic transsphenoidal surgery for pituitary adenomas at our center between January 2011 and May 2019. Variables included demographics, preoperative clinical and radiological characteristics, and postoperative radiological and endocrinological outcomes. Complications were divided into four categories: endocrinological, neurosurgical, medical, and ENT (ear–nose–throat)-related complications. Univariate and multivariate statistical analysis were performed.
Results A total of 111 patients with pituitary adenomas and a mean age of 53.7 years were included (25 ACTH, 35 GH, and 51 nonfunctioning adenomas). Overall, 28 patients had microadenomas (25.2%) and 83 had macroadenomas (74.8%). Univariate statistical analysis for complications between groups showed no differences in neurosurgical and medical complications. Transient diabetes insipidus and postsurgical bacterial sinusitis were the only variables more frequently seen in the ACTH group (p = 0.01 and 0.04, respectively). Multivariate analysis for transient diabetes insipidus showed no differences between groups (p = 0.58).
Conclusion Complication rates were similar in all three adenoma groups, particularly concerning major infections, thrombotic events, postoperative cerebrospinal fluid (CSF) leak, and transient diabetes insipidus. Transient diabetes insipidus was related with adenoma size and intraoperative CSF leak. Despite postoperative bacterial sinusitis was statistically higher in the ACTH group, this data should be interpreted with caution given the low number of patients with this complication.
Contemporary Surgical Management of Juvenile Nasopharyngeal Angiofibroma
Authors: Cohen-Cohen Salomon , Scheitler Kristen M. , Choby Garret , Janus Jeffrey , Moore Eric J. , Kasperbauer Jan L. , Cloft Harry J. , Link Michael , Gompel Jamie J. Van 
Published: March 2021

Abstract
Objectives Juvenile nasopharyngeal angiofibromas (JNAs) are uncommon tumors with an evolving treatment paradigm. The objective of this study was to compare our prior experience reported in 2005 with our most contemporary series to compare practice improvements and the impact of expanded endonasal procedures.
Design Retrospective review comparing a contemporary 22 patients with JNA who underwent surgical management between 2005 and 2019, compared with a historical cohort of 65 patients from the same center.
Results The most common presenting symptom was epistaxis (68%). The median maximum tumor diameter was 4.4 cm. All patients underwent preoperative embolization. An endoscopic endonasal approach (EEA) was used in 18 patients (82%), compared with 9% in the series prior to 2005. Gross total resection was achieved in all patients. The median estimated blood loss was 175 and 350 mL for EEA and open (transfacial) cases, respectively. Only two patients (9%) required a blood transfusion compared with 52% on the previous series. The median follow-up was 19 months. The overall recurrence rate was 9% in this series and 24% in the previous series. No patient required radiation therapy in follow-up compared with 3% in our historical cohort.
Conclusion There have been significant changes regarding the management of patients with JNA compared with the previous Mayo Clinic experience. The EEA has become the preferred route over the transfacial approaches to treat JNA in selected patients who do not have intracranial extension. Preoperative embolization has aided in reducing the postoperative transfusion rates.
The Selection of Facelift Approach on the Basis of Midfacial Ptosis
Authors: Quatela Vito C. , Ahmedli Nigar N. 
Published: March 2021

AbstractFacial aging in the midface has been described to encompass both soft tissue descent and volumetric change. Currently, there is no established and widely accepted grading system for midfacial ptosis. We propose a simplified grading system for midfacial ptosis ranging from mild to severe in terms of Grades I through III. Using this classification system, we describe an algorithm to help select the facelift approach most appropriate for each patient. The sub-superficial musculoaponeurotic system rhytidectomy, deep plane rhytidectomy, and subperiosteal midface lift techniques are described in detail. The nuances of the selection process also include a discussion on the various approaches to the orbital fat, namely a transconjunctival lower lid blepharoplasty with skin pinch versus a lower lid blepharoplasty with fat transposition, as well as the aging neck. Furthermore, we integrate the addition of postoperative adjunctive procedures which include injectables, chemical peels, and dermabrasion to address facial rejuvenation from not only a gravitational aspect but also the volumetric and textural components.
Respiratory Syncytial Virus Immunoprophylaxis with Palivizumab: 12-Year Observational Study of Usage and Outcomes in Canada
Authors: Mitchell Ian , Li Abby , Bjornson Candice L. , Lanctot Krista L. , Paes Bosco A. ,   the CARESS investigators
Published: March 2021

Objective This study aimed to evaluate palivizumab (PVZ) use, trends in indications, and outcomes of respiratory illness hospitalizations (RIH) and respiratory syncytial virus hospitalizations (RSVH).
Study Design It involves a large, Canadian prospective (2005–2017) observational multicenter study of children at high risk for RSV infection.
Results A total of 25,003 infants (56.3% male) were enrolled at 32 sites; 109,579 PVZ injections were administered. Indications included: prematurity (63.3%); “miscellaneous” (17.8%); hemodynamically significant congenital heart disease (10.5%); bronchopulmonary dysplasia/chronic lung disease (8.4%). The “miscellaneous” group increased over time (4.4% in 2005–2006 to 22.5% in 2016–2017) and included: trisomy 21, airway anomalies, pulmonary disorders, cystic fibrosis, neurological impairments, immunocompromised, cardiac aged >2 years, multiple conditions, and a residual “unclassified” group. Adherence measured by expected versus actual doses plus correct interdose interval was 64.7%. A total of 2,054 RIH occurred (6.9%); 198 (9.6%) required intubation. Three hundred thirty-seven hospitalized children were RSV-positive (overall RSVH 1.6%). Risk factors for RSVH included having siblings, attending daycare, family history of atopy, smoking exposure, and crowded household. Infants with 5 risk factors were 9.0 times (95% CI or confidence interval 4.4–18.2; p < 0.0005) more likely to have RSVH than infants without risk factors. Three adverse events occurred; none were fatal.
Conclusion Results are relevant to both clinicians and decision-makers. We confirmed the safety of PVZ. Use of PVZ increased steadily for children with miscellaneous conditions and medical complexity. Medical and social factors pose a risk for severe RIH and RSVH with accompanying burden of illness. A vaccine that protects against RSV is urgently required.
Key Points
Electroencephalogram Background Predicts Time to Full Oral Feedings in Hypoxic–Ischemic Encephalopathy
Authors: Takle Mrinmayee , Conaway Mark , Burnsed Jennifer 
Published: March 2021

Objective Infants with a history of neonatal hypoxic-ischemic encephalopathy (HIE) are at risk for oral motor dysfunction. Previous studies have associated the need for gastrostomy tube at neonatal intensive care unit discharge with brainstem injury on magnetic resonance imaging (MRI). However, the factors associated with time to full oral feeds in this population have not been previously described. This study aimed to study factors associated with time to full oral feeds in this population.
Study Design This is a single-center, retrospective study that examined these factors using Cox regression.
Results A total of 150 infants who received therapeutic hypothermia from 2011 to 2017 were included in this study. The single clinical factor significantly associated with time to full oral feeds was the severity of background abnormality on electroencephalogram in the first 24 hours of age (severe vs. mild 95% confidence interval [CI]: 0.34–0.74; moderate vs. mild 95% CI: 0.19–0.45). Brainstem injury on MRI was the factor most highly associated with need for gastrostomy tube placement (p = 0.028), though the overall incidence of need for gastrostomy tube feeds in this population was low (5%).
Conclusion These findings may help clinicians counsel families on what to expect in neonates with HIE and make decisions on the need for and timing to pursue gastrostomy tube in this population.
Key Points
Observation of a superparamagnetic breakdown in gadolinium chloride filled double-walled carbon nanotubes
Authors: Ncube S. , Coleman C. , Flahaut E. , Bhattacharyya S. , Prinsloo A. R. E. , Sheppard C. J. 
Published: March 2021

In this article, the magnetic properties of gadolinium chloride-filled double-walled carbon nanotubes (GdCl3@DWNTs) in the temperature range 2-300 K are explored. The temperature-dependent phonon frequencies of the G-band were studied from 80-300 K to investigate the effect of temperature on the magnetic ordering. Temperature-dependent susceptibility measurements show that the GdCl3@DWNTs sample has a pronounced superparamagnetic phase from 83 K. The temperature dependence of the G-band frequency for filled tubes exhibited a distinct difference compared to pristine nanotubes, where a sharp phonon hardening at low temperatures was observed. A correlation between the onset temperature of superparamagnetism and the abrupt G-band phonon hardening in the filled tubes was verified. GdCl3@DWNTs were characterized by a finite remnant magnetization at 300 K which decreased as the temperature was lowered because of the presence of the discontinuous magnetic nanoparticles, providing a superparamagnetic contribution characterized by an S-shaped non-saturating hysteresis loop at 2 K. Remarkably, the onset of superparamagnetism, marked by the bifurcation point, occurred at roughly the same temperature where the G-band phonon frequency showed a pronounced hardening at approximately 80 K, indicating a close correlation between phonon modes and spin clusters.
Concordance line sorting in The Prime Machine
Authors: Jeaco Stephen 
Published: March 2021

Abstract
Corpus data provide evidence of the patterning of language, and one way word usage can be analysed is through the
study of concordance lines. While popular concordancers provide different sorting methods, they are typically only able to display
lines in the order in which they occur in the corpus, randomly, or alphabetically by words in slots to the left or right of the
word of interest. Less sophisticated users may find recognising patterns from these orderings quite challenging. This paper
considers possible needs of language learners in terms of concordance ranking and introduces two methods which have been adopted
and developed for The Prime Machine. The first method uses repeated patterns, measuring the number of matches
made with other lines in the set. The second method incorporates collocation scores, providing examples with strong collocations
from the entire corpus at the top of sampled concordance lines.
Spritz: general relativistic magnetohydrodynamics with neutrinos
Authors: Cipolletta F , Kalinani J V , Giangrandi E , Giacomazzo B , Ciolfi R , Sala L , Giudici B 
Published: March 2021

Abstract
We here present a new version of the publicly available general relativistic magnetohydrodynamic (GRMHD) code Spritz, which now includes an approximate neutrino leakage scheme able to handle neutrino cooling and heating. The leakage scheme is based on the publicly available ZelmaniLeak code, with a few modifications in order to properly work with Spritz. We discuss the involved equations, physical assumptions, and implemented numerical methods, along with a large battery of general relativistic tests performed with and without magnetic fields. Our tests demonstrate the correct implementation of the neutrino leakage scheme, paving the way for further improvements of our neutrino treatment and the first application to magnetized binary neutron star mergers. We also discuss the implementation in the Spritz code of high-order methods for a more accurate evolution of hydrodynamical quantities.
Electrostatic doping of graphene from a LiNbO3 (0001) substrate
Authors: Yue Chen , Lu Xiaomei , Zhang Junting , Huang Fengzhen , Zhu Jinsong 
Published: March 2021

Abstract
To investigate the special electrical phenomena in a graphene/ferroelectric field-effect transistor, we perform density-functional first-principles calculations on a graphene/LiNbO3 (0001) hybrid structure, and then study the effects of a Au counter electrode and water adsorption. Graphene is p-type and n-type doped by a LiNbO3 positive and negative surface, respectively, and the conductivity increases while the Dirac cone persists. The Au counter electrode introduces an additional charge injection relative to the surface polarity and weakens the electrostatic doping effect. With the help of the electrons from the Au counter electrode, water adsorption could switch the conductive type of graphene. We also find an interesting phenomenon whereby the coupling of graphene with a negative surface is significantly stronger than that with a positive surface, possibly related to the different polar terminals (LiO3/Nb).
Mechanistic study of catalytic CO2 hydrogenation in a plasma by operando DRIFT spectroscopy
Authors: Parastaev A , Kosinov N , Hensen E J M 
Published: March 2021

Abstract
Plasma-enhanced heterogeneous catalysis offers a promising alternative to thermal catalysis for many industrially relevant processes. There is only limited mechanistic understanding about the relation between the interactions of highly energetic electrons and excited molecules with heterogeneous catalysts in a plasma and their catalytic performance. Herein, a novel operando infrared spectroscopy cell is presented allowing the investigation of surface intermediates upon exposure of a catalyst to plasma. The polyether ether ketone cell enclosure embedding a quartz reactor is operated at atmospheric pressure and can be heated to 250 °C. A case study involved the characterization of surface intermediates during CO2 hydrogenation on a Co/CeZrO4 catalyst. The temperature was monitored using online UV–Vis spectroscopy. This combined approach offers new experimental insights into plasma-catalyst synergy. The most important one is the demonstration of CO2 methanation at the catalyst surface at room temperature in a plasma.