bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS CUSTOMER PREFERENCE DALAM MEMILIH LEMBAGA KURSUS BAHASA INGGRIS
Authors: Budiarti Tamara Yutika , Suyanto AMA 
Published: March 2021

Tujuan dari penelitian ini adalah untuk mengetahui preferensi konsumen dalam memilih lembaga kursus Bahasa inggris di Indonesia.
Metode kuantitatif digunakan pada penelitian ini dengan survey kepada 405 responden yaitu konsumen jasa kursus Bahasa inggris dengan pengumpulan data melalui kuesioner menggunakan skala likert. Penelitian ini menggunakan metode purposive sampling. Teknik analisis yang digunakan dalam penelitian ini adalah analisis konjoin.
Hasil penelitian menunjukan bahwa kombinasi atribut dari kartu 13 adalah yang paling disukai oleh masyarakat, yaitu metode pengajaran dengan presentation and game learning, jumlah siswa sebanyak <15 siswa, jenis program regular, harga <Rp. 1.000.000 dan tenaga pengajar yaitu 100% native speaker. Kemudian atribut yang paling dominan disukai konsumen adalah jumlah siswa sebanyak <15 siswa dengan nilai utility sebesar 0,218 dan metode pengajaran adalah atribut yang paling penting dipertimbangkan dengan nilai sebesar 21,904%.
ANALISIS PEMASARAN MEDIA SOSIAL UNTUK MENENTUKAN INFLUENCER DAN TOPIK PEMBICARAAN (Studi Kasus: Go-Pay dan OVO)
Authors: Sisilia Assyifa Reska , Giri Refi Rifaldi Windya 
Published: March 2021

Perkembangan teknologi yang semakin pesat berdampak besar bagi kehidupan sehari-hari, termasuk pada sistem pembayaran. Sistem pembayaran yang menggunakan teknologi digital dapat mempermudah transaksi pembayaran secara non-tunai. Go-Pay dan OVO merupakan dua e-wallet terbaik sejak 2017. Ditengah persaingan yang semakin ketat Go-Pay dan OVO harus menerapkan strategi pemasaran pada media sosial. Media sosial merupakan platform yang memiliki sumber informasi mengenai pasar. Pada media sosial, perusahaan dapat menentukan akun dan topik yang dibicarakan oleh konsumen. Hasil penelitian memperlihatkan bahwa akun yang berpengaruh yaitu akun @ptinka, @alfamart, @bareksacom dan topik yang sering dibicarakan yaitu informasi, promo dan keluhan pelanggan. Berdasarkan hasil penelitian, perusahaan dapat memanfaatkan strategi pemasaran pada media sosial untuk memenuhi kebutuhan konsumen dengan menggunakan metode social network analysis dan Topic Modeling.
‘Rebooting’ het mededingingsrecht – ook het mededingingsrecht ontsnapt niet aan de digitale transitie
Authors: Kohlen Janneke , van de Sanden Mariska , Cox Manuela 
Published: March 2021

‘Rebooting’ het mededingingsrecht – ook het mededingingsrecht ontsnapt niet aan de digitale transitie
Binnen Europa bestaat de wens om digitale platforms met een poortwachtersrol aan banden te leggen via onder meer ex-anteregulering. Toegangsverplichtingen zouden daar onderdeel van uitmaken. In dit artikel worden de EU-voorstellen naast een aantal concentratiebesluiten van de ACM gelegd waarin onder meer ook toegangsverplichtingen zijn opgelegd aan digitale platforms.
Protegemos as escolas: ações de urbanismo tático nos entornos escolares de Barcelona, Espanha
Authors: Fontes Adriana Sansão 
Published: March 2021

Objetivo: Abordar a contribuição sistêmica do programa Protegemos las escuelas para o incremento dos espaços públicos, da segurança viária e da qualidade ambiental, para a valorização dos equipamentos públicos e seus entornos imediatos e para a redução dos desequilíbrios socioambientais entre os bairros.Metodologia: Estudo de caso baseado na análise dos 25 entornos escolares transformados na primeira fase da ação, visando à elaboração de uma taxonomia das intervenções.Relevância: O artigo discute a importante mudança de paradigma que caracteriza Barcelona da última década, fundamentada no deslocamento da cultura da “grandiloquência oficial” para a atenção sobre a atuação no pequeno e no ordinário, um fenômeno inserido no contexto de crise econômica e sanitária, mas também política e representativa.Resultados: Verificação da existência de cinco tipologias de praças, em ocorrências isoladas ou combinadas, com melhores ou piores desempenhos. Após onze meses de operação, o programa já foi capaz de gerar aproximadamente 3.500 m2 de novos espaços públicos para pedestres nas adjacências escolares.Contribuições: O trabalho contribui para a valorização dos espaços públicos cotidianos de pequena escala, apresentando uma experiência de urbanismo tático que tem como foco a criação de espaços públicos de permanência associados à rede escolar.Conclusão: Embora o programa ainda se encontre em fase de testes e seus alcances e limitações para o campo do projeto urbano ainda não estejam completamente revelados, pode-se destacar diferentes contribuições do caso que fornecem relevo aos distintos aspectos presentes na metodologia do urbanismo tático.
Mathematical Analysis of Uncertainty in Bangladesh Agricultural Sector
Authors: Islam Mohammad Khairul , Alam Md. Mahmud , Uddin Mohammed Forhad 
Published: March 2021

This study presents three different mathematical models for profit optimization of agricultural products in Bangladesh. The prime focus of the paper has been to develop a Mixed Integer Linear Programming (MILP) model and analyze this model for two situation of demand uncertainty. Considering demand will be known before and after production. For the mentions of above two cases, we investigate the change of solution applying least demand, maximum perhaps demand and extreme demand scenarios. I think this is real life problem and this analysis will be helpful for all types of agricultural producers. The proposed MILP model is to maximize the total profit and also to estimate the profitable production locations. The formulated MILP model were solved by A Mathematical Programming Language (AMPL) and results obtained by appropriate solver MINOS. Numerical example with the sensitivity of several parameters has been deployed to validate the models. Results show that maximum perhaps demand scenario gets better solution according to our expected value compare of other two scenarios.
Synchronous primary carcinomas of the endometrium and ovary
Authors: Sheu B.‐C. , Lin H.‐H. , Chen C.‐K. , Chao K.‐H. , Shun C.‐T. , Huang S.‐C. 
Published: July 2002

AbstractObjectives: Synchronous carcinomas of the endometrium and ovary may indicate either independently developing neoplasms or metastatic disease. The clinical implications and prognosis of these two categories are quite different. The objectives of this study were to identify and evaluate the empirical criteria and significant therapeutic implications. Method: The National Taiwan University Hospital Cancer Registry records and pathological reports from 1977 to 1994 were reviewed. Empirical criteria were used to identify synchronous primary cancers. Results: A total of 322 patients had endometrial cancer and 421 patients had ovarian cancer in our Cancer Registry records. Eleven patients had simultaneous cancer involvement of both the endometrium and ovary. Six cases fulfilled the criteria of synchronous primary carcinomas of the endometrium and ovary. Of these, five were alive and free of disease for 35–144 months (median 94.2 months). The disease‐free survival rates between patients with synchronous primary and metastatic cancers of different histologic types showed a statistically significant difference (P = 0.013). No statistical significance was noted for different histologic types (P > 0.5). Conclusions: The empirical criteria used here were useful in identifying synchronous primary cancers of the endometrium and ovary. The favorable clinical outcome may relate to early detection of early‐stage disease and low‐grade malignancy with an indolent growth rate. Surgical management with or without adjuvant therapy has a satisfactory outcome in our experience.
A comparative model of facility network design methodologies
Authors: Powell Robinson E. , Swink Morgan L. 
Published: July 2002

AbstractOperations managers use a variety of decision making tools when designing facility networks. Intuition, scenario evaluation, heuristic and optimization procedures are commonly applied. This paper discusses the relative advantages and disadvantages of the alternative methodologies for network design and proposes a cost trade‐off model for choosing the best approach. Accessibility, precision and supplemental analysis are key factors to consider during the selection process. We also present the results of a laboratory experiment which measured the performance of analysts using intuition, scenario evaluation and enhanced scenario evaluation procedures to solve realistically‐sized network design problems. The test problems included several sizes of single‐echelon, multi‐activity and two‐echelon facility network design problems. The experimental results, when embedded into the cost trade‐off model, provide quantitative guidelines for selecting the appropriate decision support procedures. Implications for practitioners, researchers and decision support system developers are provided.
C‐reactive protein and the treatment of pelvic inflammatory disease
Authors: Reljič M , Gorišek B 
Published: July 2002

AbstractObjective: The significance of C‐reactive protein (CRP) in assessing the treatment of pelvic inflammatory disease (PID) was established and compared with body temperature (BT), erythrocyte sedimentation rate (ESR) and serum leukocyte concentration (L). Method: In 51 patients with PID, 20 (39%) of them with tubo‐ovarial abscess (TOA), measurement of BT and laboratory investigations were carried out on admission and during treatment on days 3–4, 6–8 and 18–21. The changes in these values were compared with the changes in clinical condition. Result: Prior to treatment, the majority — 49 patients or 96.1% — had increased CRP values. In successful treatment, the CRP values decreased significantly in PID patients without TOA on day 3–4, in patients with TOA on day 6–8 and reached normal values in both groups on day 18–21. Changes in clinical condition were most concurrent with changes in CRP. Conclusion: In assessing PID treatment, the determination of CRP has precedence over L, ESR and BT as the percentage of patients with increased CRP is higher and because the changes in value follow the changes in clinical condition more reliably.
Calcium‐phosphorus‐magnesium homeostasis in women with threatened preterm delivery
Authors: Smolarczyk R. , Wójcicka‐Jagodzińska J. , Romejko E. , Piekarski P. , Czajkowski K. , Teliga J. 
Published: July 2002

AbstractObjective: The effect of threatened preterm delivery on calcium, phosphorus, magnesium homeostasis in the third trimester of pregnancy was investigated. Methods: Serum concentrations of total and ionized calcium, inorganic phosphorus, magnesium, total protein, albumin, total estrogens and human placental lactogen were determined in women with threatened preterm delivery at 29–36 weeks of gestation (the studied group) and in women with uncomplicated pregnancy of the same duration (the control group). Additionally, activities of total alkaline phosphatase and heat‐stable alkaline phosphatase fraction were measured. Results: Patients of the studied group compared to the control group showed decreased concentration of total calcium (2.17 ± 0.09 vs. 2.28 ± 0.13 mmol/l, P < 0.0005), inorganic phosphorus (1.13 ± 0.27 vs. 1.32 ± 0.23 mmol/l, P < 0.001) and magnesium (0.64 ± 0.07 vs. 0.70 ± 0.10 mmol/l, P < 0.003); they also demonstrated decreased activity of total alkaline phosphatase (70.8 ± 23.2 vs. 81.9 ± 14.9 IU/l, P < 0.01) and its heat‐stable fraction (30.2 ± 15.6 vs. 59.6 ± 14.9 IU/l, P < 0.001). In the studied group no difference was found in concentrations of investigated ions and enzymes between women who delivered at term and women who delivered prematurely. Patients with threatened preterm delivery showed serum deficiency of total calcium, phosphorus and magnesium which might be related to premature uterine contractility but does not predict premature labor by week 36 of gestation (66% of patients delivered at term). Conclusion: The deficiency of minerals and lowered activity of total alkaline phosphatase is observed in women with threatened preterm delivery. Laboratory tests of calcium‐phosphorus‐magnesium homeostatsis have limited predictive value in regard to the term of delivery in women with threatened preterm delivery.
Manufacturing technology and strategy formulation: keys to enhancing competitiveness and improving performance
Authors: Tracey Michael , Vonderembse Mark A , Lim Jeen‐Su 
Published: July 2002

AbstractPorter [Porter, M.E., 1996. What is strategy? Harvard Business Review 74 (6), 61–78.] claims that a proper link between strategy and manufacturing operations is a key to developing sustainable competitive advantage. To be successful in this globally competitive, rapidly changing environment, organizations must formulate strategic plans that are consistent with their investment in and use of manufacturing technology. This study proposes that organizations that invest in advanced manufacturing technology and develop mechanisms for manufacturing managers to participate in strategy formulation will have improved competitive capabilities and better performance than firms that do not. Using the result from a large‐sample survey, this study develops valid and reliable measures of advanced manufacturing technology and manufacturing managers' participation in strategy formulation as well as the competitive capabilities of a firm. Linear structural equation analysis (LISREL) results show that the relationships between a firm's practices in these two areas and its competitive capabilities are found to be statistically significant and positive. Also, high levels of these competitive capabilities lead to high levels of performance as measured by customer satisfaction and marketing performance.
Quantitative variation in vascular endothelial growth factor mRNA expression during early flexor tendon healing: an investigation in a canine model
Authors: Boyer Martin I. , Watson Jeffry T. , Lou Jueren , Manske Paul R. , Gelberman Richard H. , Cai Shi Rong 
Published: July 2002

AbstractVascular endothelial growth factor (VEGF) is a potent mediator of angiogenesis, with direct mitogenic activity on cells of endothelial origin. We quantified the temporal accumulation of VEGF mRNA at the repair site of an in vivo canine intrasynovial flexor tendon repair and rehabilitation model by means of quantitative Northern blot analysis, in order to detail a molecular signal involved in the intrinsic angiogenic process that accompanies early flexor tendon healing. Significant accumulation of VEGF mRNA occurred at the flexor tendon repair site at 7 days post‐operatively, with peak levels seen at post‐operative days 7 and 10. Levels returned to baseline by day 14.Local VEGF mRNA accumulation at the repair site temporally precedes and is spatially distinct from the vascular ingrowth itself, which has been shown to occur maximally at day 17. These data suggest that cells within the flexor tendon repair site are involved in molecular processes other than the synthesis of extracellular matrix, such as modulation of angiogenesis. © 2001 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.
Isolation of neuronal precursors from differentiating P19 embryonal carcinoma cells by neuronal Tα1‐promoter‐driven GFP
Authors: Kim Joon , Choi Seung Cheol , Kim Tae Hyung , Kim Ki Dong , Cho Si Young , Park Sung Soo , Lee Sang Ho 
Published: July 2002

AbstractThe induction of pluripotent P19 embryonal carcinoma (EC) cells with retinoic acid results in their differentiation into cells that resemble neurons, glia, and fibroblasts. To isolate and enrich the developing neurons from heterogeneously differentiating P19 EC cells, we used a recently introduced protocol combining the expression of green fluorescent protein (GFP) driven by a tissue‐specific promoter and fluorescence‐activated cell sorting. Cells were transfected with the gene for GFP, which is under the control of the neuronal Tα1 tubulin promoter. After four days of retinoic acid treatment, GFP was specifically detected in cells undergoing neuronal differentiation. Sorting of fluorescent differentiating P19 EC transfectants yielded populations highly enriched in neuronal precursors and neurons. Immunoreactivity for nestin and neurofilament was observed in 80 and 25% of the sorted cell population, respectively. These results demonstrate that differentiated neuronal precursor cells can be efficiently isolated from differentiating pluripotent embryonic cells in vitro, suggesting that this method can reproducibly provide homogeneous materials for further studies on neurogenesis.
Correlation of in vitro anti‐proliferative potential with in vivo teratogenicity in a series of valproate analogues
Authors: Courage‐Maguire Carol , Bacon Christopher L. , Nau Heinz , Regan Ciaran M. 
Published: July 2002

AbstractThe prediction that an anti‐proliferative effect coupled with a pro‐differentiative action will detect a neural tube teratogen has been validated by comparison of these in vitro endpoints with in vivo teratogenicity in a series of closely allied valproate structural analogues. The majority of the compounds significantly inhibited C6 glioma proliferation, the most potent compounds being ranked as octanoic acid >2‐propylhexanoic acid≥2‐ethylhexanoic acid≥valproic acid. The anti‐proliferative potency of these compounds did not correlate strictly to their relative in vivo teratogenic potential. Valproic acid exhibited an anti‐proliferative ic50 of 1.45 mM, whereas 2‐propyl‐2‐pentenoic acid and 2‐propyl‐4‐pentenoic acid were virtually indistinguishable, exhibiting significantly lower ic50 values of 2.5 and 2.55 mM, respectively. The concanavalin A lectin affinity assay was employed to establish whether an anti‐proliferative action was coupled with an increased state of cell differentiation. In this lectin affinity assay, the most potent analogues to significantly attenuate the affinity of exposed C6 glioma cells for concanavalin A lectin‐coated plastic included 2‐butylhexanoic acid, 2‐propyl‐4‐pentenoic acid, 2‐propylhexanoic acid and 2‐ethylhexanoic acid in a manner which can be related to their relative teratogenic potencies in vivo. All compounds screened positive in both the anti‐proliferative and pro‐differentiative assays exhibited in vivo exencephalic rates of 5–44%. These included valproic acid, 2‐ethylhexanoic acid, 2‐propylhexanoic acid and 2‐butylhexanoic acid. It would appear that combined anti‐proliferative and pro‐differentiative screens provide a promising detection system for teratogenic status in a series of valproate analogues.
Immortalized cell lines from embryonic avian and murine otocysts: Tools for molecular studies of the developing inner ear
Authors: Barald K.F. , Lindberg K.H. , Hardiman K. , Kavka A.I. , Lewis J.E. , Victor J.C. , Gardner C.A. , Poniatowski A. 
Published: July 2002

AbstractRecently, our studies have focused on genes expressed at the earliest stages of inner ear development. Our aim is to identify and characterize genes that are involved in determining the axes of the semicircular canals, in otic crest delamination and in early innervation of the inner ear. Many elegant studies of auditory development have been done in animal models. However, the need for large amounts of well‐characterized embryonic material for molecular studies makes the development of otocyst cell lines with different genetic repertoires attractive. We have therefore derived immortalized otocyst cells from two of the most widely used animal models of ear development: avians and mice. Avian cell isolates were produced from quail otocysts (embryonic stage 19) that were transformed with temperature‐sensitive variants of the Rous sarcoma virus (RSV). Among the individual transformed cells are those that produce neuron‐like derivatives in response to treatment with 10−9 M retinoic acid. Mammalian cell isolates were derived from otocysts, of 9 day (post coitus) embryos of the H2kbtsA58 transgennc mouse (Immortomouse), which carries a temperature‐sensitive variant of the Simian Virus 40 Tumor antigen. The vast majority of cells of the Immortomouse are capable of being immortalized at 33°C, the permissive temperature for transgene expression, in the presence of γterferon. Several putative clones of these cells differentiated into neuron‐like cells after temperature shift and withdrawal of γ‐interferon; another isolate of cells assumed a neuron‐like morphology on exposure to brain‐derived neurotrophic factor even at the permissive temperature. We describe also a cell isolate that expresses the Pax‐2 protein product and two putative cell lines that express the protein product of the chicken equivalent of the Drosophila segmentation gene engrailed. These genes and their protein products are expressed in specific subpopulations of otocyst cells at early stages. Both mouse and quail immortalized cell lines will be used to study inner ear development at the molecular level.
In Vitro pattern formation during neurogenesis in neuroectodermal progenitor cells immortalized by p53‐deficiency
Authors: Schlett Katalin , Herberth Balázs , Madarász Emilia 
Published: July 2002

AbstractIn vitro neural differentiation was induced in a p53‐deficient immortalized neuroectodermal progenitor cell line, NE‐4C, by treatment with retinoic acid [K. Schlett and E. Madarász (1997) J. Neurosci. Res.47, 405–416]. Rearrangement of nestin filaments was an early marker of neuron‐formation. The increase in neurofilament protein content was accompanied by a decrease in the expression of nestin filaments in induced precursors. Cells with astroglial features appeared with a delay of 4–5 days compared to the appearence of neurons.Future neurons were sorted out from the substrate‐attached population of apparently non‐induced cells. The sorting out of future neurons resembled the separation of neural precursorsin vivo. The continuous changes in the shape and also in the position of the cells resulted in the formation of characteristic morphological patterns. On the basis of morphological changes, five characteristic stages of in vitro neural differentiation were distinguished.The analysis of the morphological changes revealed that cell‐to‐cell interactions played an essential role in the cell fate decision made by induced precursors. Our observations indicate that the NE‐4C cell line can serve as an in vitro model to investigate some early steps of neurogenesis.
Breath isoprene in patients with heart failure
Authors: Lawrence T. McGrath , Robin Patrick , Bernard Silke 
Published: July 2002

AbstractBackground:Chronic heart failure (CHF) is characterised by increased vascular resistance. This increased after load on the left ventricle contributes to the vicious cycle that leads to progression of myocardial failure, multiple organ failure and death. There is evidence for increased oxidative stress in heart failure, which will influence the myocardium but also peripheral vasculature endothelium.Aims:The aim of the present study was to examine the production of isoprene, reputed to reflect oxidative stress, in patients with CHF compared to control subjects.Methods:Twelve patients with CHF and thirty‐one healthy control subjects free from heart disease were studied. Breath was collected via a two‐way non‐re‐breathing valve into a 60‐l gas collection bag. A sample of ambient air was collected at the same time. A measured aliquot of patient breath and ambient air (approx. 1.5 l) was adsorbed onto a gas adsorption tube packed with poropak‐Q. Isoprene was measured using GC/MS and the production rate calculated. All samples of breath were collected at 10.00 h after subjects had been sitting at rest for 15 min.Results:Breath isoprene production in subjects with CHF was significantly reduced compared to controls 83(23) vs. 168(20) pmol min−1 kg−1.Conclusion:Breath isoprene does not directly reflect oxidative stress in CHF.