bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of kidney‐transplanted patients with history of intestinal reconstruction of the urinary tract
Authors: Gueguen Juliette , Timsit Marc‐Olivier , Scemla Anne , Boutin Jean‐Michel , Bruyere Franck , Longuet Hélène , Sberro‐Soussan Rebecca , Legendre Christophe , Anglicheau Dany , Büchler Matthias 
Published: September 2021

AbstractBackgroundDue to increased risk of pyelonephritis, patients with intestinal reconstruction of the lower urinary tract (IRLUT) have long been advised against kidney transplantation. The aim of this study was to compare the outcomes of transplantation between patients with IRLUT and patients with normal LUT (NLUT) using propensity score matching method.MethodsThe study included 23 kidney recipients with IRLUT matched to 46 kidney recipients with NLUT using known allograft survival and pyelonephritis risk factors as covariates. One‐, 5‐, and 10‐year graft survival, pyelonephritis, and surgical complications occurrence and graft function were compared.ResultsOne‐, 5‐, and 10‐year graft survival were 96%, 91%, and 63% in the IRLUT group and 96%, 88%, and 70% in the NLUT group, respectively (p = 0.72). Patients with IRLUT had increased cumulative risk of pyelonephritis at 10 years (70% vs. 19%; log‐rank < 0.01) without impacting graft function or rejection occurrence. There was no difference in overall surgical complication, but patients with IRLUT had more urological complications than patients with NLUT (62% vs. 28%; p < 0.01).ConclusionsOur case‐control study consolidates the results regarding the safety of transplantation in patients with IRLUT using a strong validated matching method and provides new insights regarding graft function, pyelonephritis, and surgical complications in this population.
Leveraging patient‐reported outcomes (PROs) in patients with pancreatic cancer: The Pancreatic Cancer Action Network (PanCAN) online patient registry experience
Authors: Gupta Arjun , Khalid Omar , Moravek Cassadie , Lamkin Anica , Matrisian Lynn M. , Doss Sudheer , Denlinger Crystal S. , Coveler Andrew L. , Weekes Colin D. , Roeland Eric J. , Hendifar Andrew E. , Nipp Ryan D. 
Published: September 2021

AbstractBackgroundThe Pancreatic Cancer Action Network (PanCAN) Patient Registry is an online, pancreatic cancer‐specific, global registry enabling patients to self‐report sociodemographics, disease/management characteristics, and patient‐reported outcomes (PROs). We sought to describe the creation, user experience, and research potential of the PanCAN Registry.MethodsWe obtained data to describe (1) the creation of the Registry (questionnaire development, marketing efforts, and regulatory considerations); (2) the user experience (user characteristics and interactions with the registry following inception); and (3) the research potential of the registry (comparing PROs and treatment patterns by age [±65 years] and treatment site [community or academic] for users with de novo metastatic disease).ResultsThe Registry was conceived as part of PanCAN’s strategic plan for a personalized therapy initiative. PanCAN staff and disease expert consultants developed questionnaires hosted on an electronic PRO platform. Users had the option to include their data in research efforts, and the Registry platform received institutional review board approval. From 7/2015 to 12/2020, 2187 patients visited the registry and 1697 (77.6%) completed at least one survey (median age = 64 years [range: 24–90], 47.9% women, 88.7% White, 34.0% metastatic disease). Among patients with metastatic disease (N = 567), 46.0% were ≥65 years old and 67.5% received treatment at community sites. Patients ≥65 years reported feeling less hopeful about the treatment plan (12.4% vs. 24.3%, p = 0.003), and patients treated at community sites reported more frequent treatment breaks of >2 weeks (58.2% vs. 28.1%, p < 0.001).ConclusionsOur findings demonstrate the feasibility, usability, and research potential of an online PRO registry for patients with cancer. This description of the PanCAN Registry should inform future registry‐building efforts to facilitate standardized PRO reporting and provide a valuable research database.Clinical trial registration number: Not applicable.
Clinical outcomes according to lesion complexity in high bleeding risk patients treated with 1‐month dual antiplatelet therapy following PCI: Analysis from the Onyx ONE clear study
Authors: Kandzari David E. , Kirtane Ajay J. , Mehran Roxana , Price Matthew J. , Simon Daniel I. , Latib Azeem , Kedhi Elvin , Abizaid Alexandre , Worthley Stephen G. , Zaman Azfar , Hudec Martin , Stoler Robert , Choi James W. , Kanitkar Mihir , Conradie Andre , Tam Chor‐Cheung Frankie , Walton Antony , Gruberg Luis , Ando Kenji , Lee Lilian C. , Lung Te‐Hsin , Windecker Stephan , Stone Gregg W. 
Published: September 2021

AbstractObjectivesTo compare clinical outcomes in high bleeding risk (HBR) patients with and without complex percutaneous coronary intervention (PCI) treated with Resolute Onyx zotarolimus‐eluting stents (ZES) after 1‐month dual antiplatelet therapy (DAPT).BackgroundPCI with 1‐month DAPT has been demonstrated to be safe in HBR patients treated with Resolute Onyx ZES. Whether these outcomes are consistent in patients with complex lesions is uncertain.MethodsAmong HBR patients who were event‐free 1 month after PCI with ZES and treated thereafter with single antiplatelet therapy (SAPT), the clinical outcomes between 1 month and 1 year were compared after complex PCI (3 vessels treated, ≥ 3 lesions treated, total stent length > 60 mm, bifurcation with ≥ 2 stents implanted, atherectomy, or left main, surgical bypass graft or chronic total occlusion PCI) versus noncomplex PCI. Propensity score adjustment was performed to adjust for baseline differences among complex and noncomplex patients.ResultsComplex patients (N = 401, 26.6% of total) had a higher prevalence of hyperlipidemia, diabetes mellitus and previous myocardial infarction (MI). Between 1 month and 1 year, rates of MI (7.1% vs. 4.0%, p = 0.02) and cardiac death/MI (9.3% vs. 6.1%, p = 0.04) were higher among complex versus noncomplex patients, although stent thrombosis rates were similar. After adjustment for baseline characteristics, differences in outcomes were no longer significant between groups.ConclusionsHigher rates of ischemic outcomes in complex PCI patients were largely explained by baseline clinical differences, rather than lesion complexity, among HBR patients treated with 1‐month DAPT following PCI with Resolute Onyx ZES.
Reversible pH‐Controlled Catenation of a Benzobisimidazole‐Based Tetranuclear Rectangle
Authors: Dekhtiarenko Maksym , Pascal Simon , Elhabiri Mourad , Mazan Valerie , Canevet David , Allain Magali , Carré Vincent , Aubriet Frédéric , Voitenko Zoia , Sallé Marc , Siri Olivier , Goeb Sébastien 
Published: September 2021

AbstractThe development of methodologies to control on demand and reversibly supramolecular transformations from self‐assembled metalla‐structures requires the rational design of architectures able to answer to an applied stimulus. While solvent or concentration changes, light exposure or addition of a chemical have been largely explored to provide these transformations, the case of pH sensitive materials is less described. Herein, we report the first example of a pH‐triggered dissociation of a coordination‐driven self‐assembled interlocked molecular link. It incorporates a pH sensitive benzobisimidazole‐based ligand that can be selectively protonated on its bisimidazole moieties. This generates intermolecular electrostatic repulsions that reduces drastically the stability of the interlocked structure, leading to its dissociation without any sign of protonation of the pyridine moieties involved in the coordination bonds. Importantly, the dissociation process is reversible through addition of a base.
A multi‐institutional study of salivary gland cytopathology: Application of the Milan System for Reporting Salivary Gland Cytopathology in Japan
Authors: Higuchi Kayoko , Urano Makoto , Akiba Jun , Nogami Miwako , Hirata Yukiya , Zukeran Yoko , Moriyoshi Koki , Tada Yuichiro , Fukushima Mana , Obayashi Mariko , Sakamoto Shinnichi , Kuraoka Kazuya , Kira Kana , Kawahara Akihiko , Kato Taku , Tanigawa Maki , Nakaguro Masato , Yamamoto Hidetaka , Nagao Toshitaka 
Published: September 2021

BackgroundThe Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) is a risk‐stratification reporting system that was introduced in 2018. The objective of this multi‐institutional study was to evaluate the utility of the MSRSGC in Japan.MethodsIn total, 1608 fine‐needle aspiration samples with matching histologic diagnoses were retrieved from 12 large institutions in Japan. The diagnostic categories of the MSRSGC were assigned prospectively or retrospectively, and the results were compared with the histologic diagnoses.ResultsThe cases were classified as follows: nondiagnostic, 18.1%; non‐neoplastic, 4.1%; atypia of undetermined significance, 11.5%; neoplasm‐benign, 43.7%; salivary gland neoplasm of uncertain malignant potential, 9.6%; suspicious for malignancy, 3.6%; and malignant, 9.4%. The risk of neoplasm and the risk of malignancy in each MSRSGC category were as follows: nondiagnostic, 72.9% and 13.4%, respectively; non‐neoplastic, 15.2% and 9.1%, respectively; atypia of undetermined significance, 77.9% and 24.9%, respectively; neoplasm‐benign, 99% and 1.8%, respectively; salivary gland neoplasm of uncertain malignant potential, 94.8% and 37%, respectively; suspicious for malignancy, 100% and 89.7%, respectively; and malignant, 100% and 99.3%, respectively. The accuracy of the MSRSGC for diagnosing neoplasms was 97.8%, and its accuracy for diagnosing malignancy was 97.3%. Institutions that used Romanowsky‐stained preparations had lower nondiagnostic rates and lower risks of neoplasm and malignancy in the non‐neoplastic category.ConclusionsThe MSRSGC is useful for risk stratification and quality control. Widespread use of the MSRSGC would improve the accuracy of salivary gland cytology and lead to better patient care in Japan.
A new hierarchy framework for feature engineering through multi‐objective evolutionary algorithm in text classification
Authors: Asgarnezhad Razieh , Monadjemi S. Amirhassan , Aghaei Mohammadreza Soltan 
Published: September 2021

SummarySentiment classification is a field of sentiment analysis concerned with analyzing opinions, emotions, evaluations, and attitudes regarding a special topic like a product, an organization, a person, or an incident. With the growth of user‐generated content on the Web, this field gained great importance in online reviews. With a wide range of reviews, customers cannot read all reviews. Considering the increasing rate of electronic documents and the urgent need manually mine for keywords that are hard and time‐consuming, doing the same automatically is of high demand. A new framework proposed here to mine and classify users' comments based on mining keywords by applying the sequence pattern mining through the Separation‐Power concept, a multi‐objective evolutionary algorithm based on decomposition with four objectives, and a neural network as the final classifier. Some modifications are made on multi‐objective evolutionary algorithm based on decomposition and Apriori algorithms to improve the text classification efficiency. To evaluate the proposed framework, three datasets applied; which compared with the two methods to measure accuracy, precision, recall, and error‐index. The results indicate that this framework provides a better outcome than its counterparts with 99.45 precision, 99.34 accuracy, 99.48 recall, and 99.28% f‐measure.
Grass carp larval density synchronised with river discharge fluctuations in the subtropical Pearl River, China
Authors: Zhang Yingqiu , Li Xinhui , Li Jie , Li Yuefei 
Published: September 2021

AbstractRiver discharge/flow exerts fundamental driving effects on the river ecosystem and larval abundance dynamics. In the subtropical Pearl River, China, the species‐specific effects of river discharge on the occurrence of grass carp larvae remain unknown. We performed cross wavelet analysis, using data on the daily density of larvae collected from 2006 to 2013 at a fixed site downstream in the Pearl River, to explore the temporal correlation between river discharge/water temperature and larval density. We further used the conditional random forest and generalised additive models to determine relevant environmental effects on their relationship. Grass carp larvae appeared from late April to early October, but mainly during June and July. River discharge, but not water temperature, showed significant coherence and in‐phase relationship with larval density. For discharge in significant coherence with larval density, it ranged from 4,740 to 28,700 m3/s, with peak discharge from 4,900 to 30,900 m3/s, and the discharge fluctuation state from −16 to 10 days (where − indicates the falling stage and + the rising stage). Maximum daily temperature/water temperature, ammonia‐nitrogen concentration, peak discharge and discharge contributed the most to the variations in coherence and phase relationships between discharge and larval densities over the short timescale (<32 days) and accounted for 22.4% of coherence variation, 19.7% of in‐phase degrees and 15% of variation in phase lagging. These suggest that a combination of ecological regulation and water environment control would be efficient to promote the recruitment of grass carp and relevant freshwater fish species.
Reactivity of Terminal Iron Borylenes and Bis(borylenes) with Carbodiimides: Cycloaddition, Metathesis, Insertion and C−H Activation Pathways
Authors: Matler Alexander , Arrowsmith Merle , Schorr Fabian , Hermann Alexander , Hofmann Alexander , Lenczyk Carsten , Braunschweig Holger 
Published: September 2021

AbstractThe reactions of carbodiimides with the iron arylborylene complex [Fe=BDur(CO)3(PMe3)] (Dur=2,3,5,6‐Me4C6H) and the iron bis(borylene) complex [Fe{=BDur}{=BN(SiMe3)2}(CO)3] yield a wide variety of temperature‐dependent products, including known FeBNC and novel FeBNB metallacycles, complexes of N‐heterocyclic boracarbene and spiro‐boracarbene ligands and a unique 1,3,2,4‐diazadiborolyl pianostool complex, characterized by NMR spectroscopy and X‐ray crystallography. The product distributions can be rationalized by considering sequences of cycloaddition, metathesis, insertion, and C−H activation pathways mainly governed by sterics.
The role of bathymetry and directional wave conditions on observed crescentic bar dynamics
Authors: de Swart Rinse L. , Ribas Francesca , Simarro Gonzalo , Guillén Jorge , Calvete Daniel 
Published: September 2021

AbstractNearshore sandbars are important features in the surf zone of many beaches because they strongly influence the mean circulation and evolving morphology. Due to variations in wave conditions, sandbars can experience cross‐shore migration and vary in shape from alongshore uniform (shore‐parallel) to alongshore rhythmic (crescentic). Sandbar dynamics have been studied extensively, but existing observational studies usually do not quantify the processes leading to crescentic bar formation and straightening. This study analyses the dynamics of crescentic bar events at the fetch‐limited beach of Castelldefels (northwestern Mediterranean Sea, Spain) using 7.5 years of hourly time‐exposure video images and detailed wave conditions. The results show that, despite the generally calm wave conditions, the sandbars were very dynamic in the cross‐shore and longshore directions. They often migrated rapidly offshore during storms (up to 70 m in one day) and more slowly onshore during post‐storm conditions. Crescentic bars were often present at the study site (48% of the time), but only when the sandbar was at least 10 m from the shoreline. They displayed a large variability in wavelengths (100–700 m), alongshore migration speeds (0–50 m/day) and cross‐shore amplitudes (5–20 m). Wavelengths increased for larger bar–shoreline distances and the alongshore migration speeds were strongly correlated with the alongshore component of the radiation stresses. Crescentic patterns typically developed during low–medium energetic waves with limited obliquity (
° at 10 m depth), while bar straightening occurred during medium–high energetic waves with strong oblique angles of incidence (
°). Overall, this study provides further proof for the important role of wave direction in crescentic bar dynamics and highlights the strong dependence of crescentic bar development on the initial bathymetric configuration.
Strategies and interventions for improving safety culture in Australian Emergency Departments: A modified Delphi study
Authors: Alshyyab Muhammad Ahmed , FitzGerald Gerard , Albsoul Rania Ali , Ting Joseph , Kinnear Frances B. , Borkoles Erika 
Published: September 2021

AbstractBackgroundPatient safety and safety culture are critical for quality healthcare delivery in general and in Emergency Departments (EDs) in particular. The aim of this study is to identify strategies that may contribute to the improvement and maintenance of patient safety culture and which are considered most feasible in the ED environment.MethodsA two‐step modified Delphi method with 11 experts' panel was performed to establish consensus. A list of potential expert participants with a background in patient safety culture in EDs was compiled through the professional networks of the supervisory team. Snowball sampling was used to identify additional possible participants. The expert panel included key leaders in the emergency medicine community in Queensland, Australia: patient safety experts and researchers, patient safety directors, and healthcare providers in an Australian ED The study ran from September 2018 to December 2018. The tool used in Round 1 in this study was developed through triangulating the outcomes of a review of literature, results from a survey of ED staff and findings from semi‐structured interviews with key stakeholders in ED. The results from Round 1 informed the development of the Round 2 tool. The responses from the Delphi Round 1 tool were analysed as both qualitative data and quantitative data. The responses from the Delphi Round 2 tool were treated as quantitative data and analysed with the SPSS software. Consensus was calculated based on more than 80% agreement in collapsed categories 1 and 2 (or 4 and 5) of the five‐point Likert scale.ResultsOnly six strategies out of 17 (35%) achieved consensus for both importance and feasibility. These strategies may therefore be considered the most important and feasible key strategies for improving safety culture in EDs. Seven strategies (41.1%) achieved consensus for importance, but not for feasibility and four strategies (23.55%) did not achieve consensus for either importance or feasibility.ConclusionsThis study offers practical solutions for safety culture improvement in the ED context. Six key strategies were seen as both important and feasible and these grouped into three main themes; leadership through agenda setting, operational management approaches to reinforce the agenda and commitment, and systems and structures to reinforce the agenda and monitor progress.
Estimation of sub‐annual inter‐catchment groundwater flow using short‐term water balance method
Authors: Egusa Tomohiro , Oda Tomoki , Sato Takanori , Kumagai Tomo'omi 
Published: September 2021

AbstractPredicting inter‐catchment groundwater flow (IGF) is essential because IGF greatly affects stream water discharge and water chemistry. However, methods for estimating sub‐annual IGF and clarifying its mechanisms using minimal data are limited. Thus, we quantified the sub‐annual IGF and elucidated its driving factors using the short‐term water balance method (STWB) for three forest headwater catchments in Japan (named here catchment A, B and As). Our previous study using the chloride mass balance indicated that annual IGF of catchment A (49.0 ha) can be negligible. Therefore, we calculated the daily evapotranspiration (ET) rate using the Priestley–Taylor expression and the 5‐year water balance in catchment A (2010–2014). The sub‐annual IGF of the three catchments was then calculated by subtracting the ET rate from the difference between rainfall and stream discharge during the sub‐annual water balance periods selected using the STWB. The IGF rates of catchment B (7.0 ha), which is adjacent to catchment A, were positive in most cases, indicating that more groundwater flowed out of the catchment than into it, and exhibited positive linear relationships with rainfall and stream discharge. This suggested that as the catchments became wetter, more groundwater flowed out of catchment B. Conversely, the IGF rates of catchment As (5.3 ha), included in catchment A, were negative in most cases, indicating that more groundwater flowed into the catchment than out from it, and exhibited negative linear relationships with rainfall and stream discharge. Given the topography of the catchments studied, infiltration into the bedrock was the probable reason for the IGF outflow from catchment B. We hypothesized that in catchment As, the discrepancy between the actual hydrological boundary and the surface topographic boundary could have caused an IGF inflow. This study provides a useful tool for determining an IGF model structure to be incorporated into rainfall‐runoff models.
Sexual health in parous women with a history of polycystic ovary syndrome: A national cross‐sectional study in Denmark
Authors: Nohr Ellen A. , Hansen Anne‐Sofie Bang , Andersen Marianne Skovsager , Hjorth Sarah 
Published: September 2021

AbstractObjectiveTo examine associations between polycystic ovary syndrome (PCOS) and sexual health in midlife.MethodsWe included 31 645 mothers from the Danish National Birth Cohort who participated in a Maternal Follow up in 2013–14. A lifetime PCOS diagnosis was self‐reported. Sexual health was assessed by specific sexual problems including reduced sexual desire, insufficient lubrication, difficulty in obtaining orgasm, vaginismus and pain during intercourse within the past year. We also generated a combined outcome which was positive if the women reported one or more sexual problems. Logistic regression was used to estimate adjusted odds ratios (aOR) for sexual problems with 95% confidence intervals (CI).ResultsParticipants were on average 44 years old, and 920 women (2.9%) had ever had PCOS. One or more sexual problems were more often reported in women with PCOS compared with other women (42.6% versus 36.3%, aOR 1.29, 95% CI 1.13–1.48). Especially reduced sexual desire (25.6% versus 21.0%, aOR 1.29, 95% CI 1.10–1.50) and dyspareunia (11.4% versus 8.7%, aOR 1.34, 95% CI 1.09–1.66) were more frequent in women with PCOS. These associations were slightly weakened when further adjusting for mental and somatic health problems.ConclusionOur data suggest that PCOS is linked to long‐term impaired sexual health, especially reduced sexual desire and dyspareunia.