bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validity of Pediatric Early Warning Score in Predicting Unplanned Pediatric Intensive Care Unit Readmission
Authors: Zoham Mojdeh Habibi , Mohammadpour Masoud , Yaghmaie Bahareh , Hadizadeh Amere , Eskandarizadeh Zahra , Beigi Effat H. 
Published: September 2021

AbstractDespite the fact that unscheduled readmission to pediatric intensive care units (PICUs) has significant adverse consequences, there is a need for a predictive tool appropriate for use in the clinical setting. The aim of this study was to assess the ability of the modified Brighton pediatric early warning score (PEWS) to identify children at high risk for early unplanned readmission. In this retrospective cohort study, all patients aged 1 month to 18 years of age discharged from PICUs of two tertiary children's hospitals during the study interval were enrolled. Apart from demographic data, the association between PEWS and early readmission, defined as readmission within 48 hours of discharge, was analyzed by multivariable logistic regression. From 416 patients, 27 patients had early PICU readmission. Patients who experienced readmission were significantly younger than the controls. (≤12 months, 70.4 vs. 39.1%, p = 0.001) Patients who were admitted from the emergency room (66.7 and 33.3% for emergency department (ED) and floor, respectively, p = 0.012) had higher risk of early unplanned readmission. PEWS at discharge was significantly higher in patients who experienced readmission (3.07 vs. 0.8, p < 0.001). A cut-off PEWS of 2, with sensitivity 85.2% and specificity 78.1%, determined the risk of unplanned readmission. Each 1-point increase in the PEWS at discharge significantly increases the risk of readmission (odds ratio [OR] = 3.58, 95% confidence interval [CI]: [2.42–5.31], p < 0.001). PEWS can be utilized as a useful predictive tool regarding predicting unscheduled readmission in PICU. Further large-scale studies are needed to determine its benefits in clinical practice.
Pulsatile Lavage Improves Tibial Cement Penetration and Implant Stability in Medial Unicompartmental Arthroplasty: A Cadaveric Study
Authors: Eckert Johannes A. , Bitsch Rudi G. , Schroeder Stefan , Schwarze Martin , Jaeger Sebastian 
Published: September 2021

AbstractCemented unicompartmental knee arthroplasty (UKA) shows good survivorship and function. However, implant failure, causing the need for revision, can occur. Aseptic loosening is still among the most common reasons for revision. The purpose of this study was to assess the influence of preimplantation lavage technique on tibial cement penetration depth, tibial cement volume, and load to fracture in the tibial component of mobile-bearing UKA. In 10 pairs of fresh frozen human tibiae, cemented UKA was implanted by an experienced surgeon. Tibial components were then implanted, left and right tibiae were randomly allocated to group A or B. Prior to implantation, irrigation was performed with either syringe lavage or pulsatile jet lavage in a standardized manner. Cement surface was 4170.2 mm2 (3271.6–5497.8 mm2) in the syringe lavage group, whereas the jet lavage group showed 4499.3 mm2 (3354.3–5809.1 mm2); cement volume was significantly higher as well (4143.4 mm3 (2956.6–6198.6 mm3) compared with 5936.9 mm3 (3077.5–8183.1 mm3)). Cement penetration depth was 2.5 mm (1.7–3.2 mm) for the jet lavage, and 1.8 mm (1.2–2.4 mm) for the syringe lavage. The mean fracture load was 4680 N in the jet lavage group and 3800 N in the syringe lavage group (p = 0.001). Subsidence was significantly higher for syringe lavage. This study suggests a correlation of cement penetration depth and cement volume to implant failure in the tibial component of a UKA using a cadaveric model. The type of bone lavage most likely influences these two key parameters.
Gonyautoxins 2/3 Local Periarticular Injection for Pain Management after Total Knee Arthroplasty: A Double-Blind, Randomized Study
Authors: Hinzpeter Jaime , Barahona Maximiliano , Aliste Julián , Barrientos Cristian , Zamorano Alvaro , Palet Miguel , Catalan Jaime , Campo Miguel del , Lagos Néstor 
Published: September 2021

AbstractThe purpose of this study was to compare the efficacy of periarticular infiltration of gonyautoxin 2/3 (GTX 2/3) and a mixture of levobupivacaine, ketorolac, and epinephrine for pain management after total knee arthroplasty (TKA). Forty-eight patients were randomly allocated to receive periarticular infiltration of 40 µg GTX 2/3 (n = 24) diluted in 30 mL of sodium chloride 0.9% (study group) or a combination of 300 mg of levobupivacaine, 1 mg of epinephrine, and 60 mg ketorolac (n = 24) diluted in 150 mL of sodium chloride 0.9% (control group). Intraoperative anesthetic and surgical techniques were identical for both groups. Postoperatively, all patients received patient-controlled analgesia (morphine bolus of 1 mg; lockout interval of 8 minutes), acetaminophen, and ketoprofen for 72 hours. A blinded investigator recorded morphine consumption, which was the primary outcome. Also, the range of motion (ROM) and static and dynamic pain were assessed at 6, 12, 36, and 60 hours after surgery. The incidence of adverse events, time to readiness for discharge, and length of hospital stay were also recorded. The median of total cumulative morphine consumption was 16 mg (range, 0–62 mg) in the GTX 2/3 group and 9 mg (range, 0–54 mg) in control group, which did not reach statistical difference (median test, p = 0.40). Furthermore, static and dynamic pain scores were similar at all time intervals. GTX 2/3 was inferior in range of motion at 6 and 12 hours; nevertheless, we noted no difference after 36 hours. No differences between groups were found in terms of complications, side effects, or length of hospital stay. No significant differences were found between groups in terms of breakthrough morphine requirement. However, local anesthetic use resulted in an increased ROM in the first 12 hours. This prospective randomized clinical trial shows that GTX 2/3 is a safe and efficient drug for pain control after TKA; nevertheless, more studies using GTX 2/3 with larger populations are needed to confirm the safety profile and efficiency. This is level 1 therapeutic study, randomized, double-blind clinical trial.
Localized Pigmented Villonodular Synovitis Originating from the Lateral Meniscus in a 17-year-old: Case Report and Literature Review of Meniscal-Associated Localized PVNS
Authors: Talley-Bruns Rachel C. , Patel Ruby G. , Mangion Jeremy E. 
Published: September 2021

AbstractTenosynovial giant cell tumors (TSGCT) are benign tumors originating from the synovial joint, bursa, or tendon sheath. Localized pigmented villonodular synovitis (PVNS), a subtype of TSGCT, commonly affects the hands and feet and has also been reported in the literature in the knee joint. There is sparse literature on localized PVNS arising specifically from meniscal tissue. We present a case report of a 17-year- old male with symptoms and MRI findings consistent with a lateral meniscus tear. Intraoperatively, the patient was found to have a mass originating from the torn meniscal tissue, which was confirmed by pathology to be a TSGCT. We performed a literature review of intra-articular localized PVNS within the knee presenting as a meniscal tear.
Who is to Blame?
Authors: Lin Chenyang 
Published: September 2021

AbstractCritical discourse analysis (CDA) has been broadly applied to understand the social implications of discourse, yet few studies have compared different forms of discourse in Chinese media, especially on the topic of race. Referencing the CDA framework, this study compares two sample news items from Mainland China and Taiwan about the killing of George Floyd and the associated social movements, analyzing their presentational forms, sourcing patterns, headlines, lexical and syntactic choices. A racial analysis is also conducted to better comprehend how racism is constructed and potentially reproduced in Chinese media. The results suggest that the two media sources bifurcate in reporting styles – due to respective journalistic environments and regulations – and their attitudes towards the cause of the reported event. However, they both explicitly identify the issue of racism in the US. This study applies CDA in a non-US context to uncover the reporting styles and racial connotations in Chinese news discourse from Mainland China and Taiwan, identifying future directions for racial discourse analysis in Chinese media.
Critical screening parameters and critical behaviors of one-electron systems with screened Coulomb potentials
Authors: Jiao Li Guang , Xie Hui Hui , Liu Aihua , Montgomery H E , Ho Yew Kam 
Published: September 2021

Abstract
The critical screening parameters for one-electron systems screened by Hulthén, Debye–Hückel, and exponential cosine screened Coulomb potentials are calculated with an accuracy close to the precision of numerical arithmetic. The results for a H atom with an infinitely heavy nucleus are reported from the ground to high-lying excited states, and those for arbitrary two-body charged systems are derived from the Zm-scaling law. A thorough comparison of the critical screening parameters for the ground and the first p-wave excited states with previous predictions is made to demonstrate the accuracy of our calculations. The critical behaviors of system-bound and pseudo-continuum eigenenergies for s- and non-s-wave states are shown to follow the quadratic and linear laws, respectively. The variation of the corresponding wave functions is analyzed in detail. For systems with non-zero orbital angular momenta, the bound states convert into shape-type resonances when the screening parameter exceeds the critical value. The resonance energy shares the same linear law as the pseudo-continuum state, while the resonance width varies by an l-dependent power law. It is further shown that the different asymptotic behaviors of the resonance energy and width are consistent with the complex analog of the Hellmann–Feynman theorem.
A low-cost and high-efficiency method for four-inch silicon nano-mold by proximity UV exposure
Authors: Sun Lei , Zou Helin , Sang Shengbo 
Published: September 2021

Abstract
Nano-mold is an essential tool for nano-imprinting. However, large-area nano-mold fabrication relies on expensive equipment or complicated processing. Silicon nano-molds were achieved by proximity ultraviolet lithography and reactive ion etching (RIE). By optimizing the parameters in the processes of exposure, development, and RIE, silicon nano-mold with nano-scale ridges were fabricated with high-precision. The achieved minimum width of nano-ridges was 263 nm. This method is capable of fabricating silicon nano-mold covering four-inch wafer, which is simple, efficient and free from costly equipment.
Quantum sensing of the electron electric dipole moment using ultracold entangled Fr atoms
Authors: Aoki T , Sreekantham R , Sahoo B K , Arora Bindiya , Kastberg A , Sato T , Ikeda H , Okamoto N , Torii Y , Hayamizu T , Nakamura K , Nagase S , Ohtsuka M , Nagahama H , Ozawa N , Sato M , Nakashita T , Yamane K , Tanaka K S , Harada K , Kawamura H , Inoue T , Uchiyama A , Hatakeyama A , Takamine A , Ueno H , Ichikawa Y , Matsuda Y , Haba H , Sakemi Y 
Published: September 2021

Abstract
We propose a method to measure the electron electric dipole moment (eEDM) using ultracold entangled francium (Fr) atoms trapped in an optical lattice, yielding an uncertainty below the standard quantum limit. Among the alkali atoms, Fr offers the largest enhancement factor to the eEDM. With a Fr based experiment, quantum sensing using quantum entangled states could enable a search for the eEDM at a level below 10−30
ecm. We estimate statistical and systematic errors attached to the proposed measurement scheme based on this quantum sensing technique. A successful quantum sensing of the eEDM could enable the exploration of new physics beyond the standard model of particle physics.
The ClearSight System for Postoperative Arterial Blood Pressure Monitoring After Carotid Endarterectomy: A Validation Study
Authors: Fassaert Leonie M M , Plate Joost D J , Westerink Jan , Immink Rogier V , de Borst Gert J 
Published: September 2021

Abstract

BACKGROUND
The majority of postoperative events in patients undergoing carotid endarterectomy (CEA) are of hemodynamic origin, requiring preventive strict postoperative arterial blood pressure (BP) control. This study aimed to assess whether BP monitoring with noninvasive beat-to-beat ClearSight finger BP (BPCS) can replace invasive beat-to-beat radial artery BP (BPRAD) in the postoperative phase.

METHODS
This study was a single-center clinical validation study using a prespecified study protocol. In 48 patients with symptomatic carotid artery stenosis, BPCS and BPRAD were monitored ipsilateral in a simultaneous manner during a 6-hour period on the recovery unit following CEA. Primary endpoints were accuracy and precision of BP derived by ClearSight (Edward Lifesciences, Irvine, CA) vs. the reference standard (Arbocath 20 G, Hospira, Lake Forest, IL) to investigate if BPCS is a reliable noninvasive alternative for BP monitoring postoperatively in CEA patients. Validation was guided by the standard set by the Association for Advancement of Medical Instrumentation (AAMI), considering a BP-monitor adequate when bias (precision) is &lt;5 (8) mm Hg. Secondary endpoint was percentage under- and overtreatment, defined as exceedance of individual postoperative systolic BP threshold by BPRAD or BPCS in contrast to BPCS or BPRAD, respectively.

RESULTS
The bias (precision) of BPCS compared to BPRAD was −10 (13.6), 8 (7.2) and 4 (7.8) mm Hg for systolic, diastolic and mean arterial pressure (MAP), respectively. Based on BPCS, undertreatment was 5.6% and overtreatment was 2.4%; however, percentages of undertreatment quadrupled for lower systolic BP thresholds.

CONCLUSIONS
Noninvasive MAP, but not systolic and diastolic BP, was similar to invasive BPRAD during postoperative observation following CEA, based on AAMI criteria. However, as systolic BP is currently leading in postoperative monitoring to adjust BP therapy on, BPCS is not a reliable alternative for BPRAD.
Transarterial chemoembolization of hepatocellular carcinoma before liver transplantation and risk of post-transplant vascular complications: a multicentre observational cohort and propensity score-matched analysis
Authors: Sneiders D , Boteon A P C S , Lerut J , Iesari S , Gilbo N , Blasi F , Larghi Laureiro Z , Orlacchio A , Tisone G , Lai Q , Pirenne J , Polak W G , Perera M T P R , Manzia T M , Hartog H 
Published: September 2021

Abstract

Background
Transarterial chemoembolization (TACE) in patients with hepatocellular cancer (HCC) on the waiting list for liver transplantation may be associated with an increased risk for hepatic artery complications. The present study aims to assess the risk for, primarily, intraoperative technical hepatic artery problems and, secondarily, postoperative hepatic artery complications encountered in patients who received TACE before liver transplantation.

Methods
Available data from HCC liver transplantation recipients across six European centres from January 2007 to December 2018 were analysed in a 1 : 1 propensity score-matched cohort (TACE versus no TACE). Incidences of intraoperative hepatic artery interventions and postoperative hepatic artery complications were compared.

Results
Data on postoperative hepatic artery complications were available in all 876 patients (425 patients with TACE and 451 patients without TACE). Fifty-eight (6.6 per cent) patients experienced postoperative hepatic artery complications. In total 253 patients who had undergone TACE could be matched to controls. In the matched cohort TACE was not associated with a composite of hepatic artery complications (OR 1.73, 95 per cent c.i. 0.82 to 3.63, P = 0.149). Data on intraoperative hepatic artery interventions were available in 825 patients (422 patients with TACE and 403 without TACE). Intraoperative hepatic artery interventions were necessary in 69 (8.4 per cent) patients. In the matched cohort TACE was not associated with an increased incidence of intraoperative hepatic artery interventions (OR 0.94, 95 per cent c.i. 0.49 to 1.83, P = 0.870)

Conclusion
In otherwise matched patients with HCC intended for liver transplantation, TACE treatment before transplantation was not associated with higher risk of technical vascular issues or hepatic artery complications.
Cumulative Childhood Adversity and Long-Term Educational Outcomes in Individuals with Out-of-Home Care Experience: Do Multiples Matter for a Population Defined by Adversity?
Authors: Forsman Hilma , Jackisch Josephine 
Published: September 2021

Abstract
Previous research has demonstrated a graded relationship between cumulative childhood adversity and adverse later outcomes. Individuals with out-of-home care (OHC) experience constitute a population characterised by both childhood and educational disadvantages. Based on a fifty-year follow-up of a Stockholm cohort born in 1953, the purpose of this study was to examine the associations between cumulative childhood adversity and long-term educational outcomes in this group. The cumulative disadvantage perspective suggests that there would be a negative association, while the disadvantage saturation perspective implies that cumulative adversity would be less consequential for disadvantaged individuals. By means of multigroup path analysis, we furthermore asked whether this association may differ in relation to individuals with child welfare contact (CWC) and to the general population (GP). Adjusting for socioeconomic conditions and cognitive ability, cumulative childhood adversity had a negative influence on midlife educational attainment in the GP. However, it did not seem to influence the educational outcomes of neither OHC experienced individuals nor individuals with other types of CWC. The results of this study thus lend support to the disadvantage saturation perspective. Further studies are needed to explore this relationship.
Adaptive divergence in the neglected alpine mossLewinskya killiasii(Orthotrichaceae), an example of vicariance on different rock types in bryophytes
Authors: Kiebacher Thomas , Köckinger Heribert , Kučera Jan 
Published: September 2021

AbstractWe provide an example of ecological vicariance among two epilithic, high mountain taxa of mosses. Phylogenetic analyses using plastid (rps4-trnS, atpB-rbcL, trnL-trnF) and nuclear (EST-115, EST-317, ITS region) markers and morphological data revealed the distinctiveness of the neglected Orthotrichum killiasii, here resurrected from the synonymy of Lewinskya speciosa and newly combined in Lewinskya. Furthermore, our data indicate a speciation process within O. killiasii related to the rock type inhabited (silicate vs. carbonate). We translate this into the recognition of two subspecies, corresponding to O. killiasii s.s. and the recently described O. simonyi. The incongruence between nuclear and plastid markers in some accessions and the partial but rare incongruence between ITS ribotypes and the morphological manifestation in phenotypes indicate incomplete lineage sorting with respect to rather recent segregation and possible gene flow between the two entities.
Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis
Authors: Taha Doaa M , Clarke Benjamin E , Hall Claire E , Tyzack Giulia E , Ziff Oliver J , Greensmith Linda , Kalmar Bernadett , Ahmed Mhoriam , Alam Aftab , Thelin Eric P , Garcia Nuria Marco , Helmy Adel , Sibley Christopher R , Patani Rickie 
Published: September 2021

Abstract
Amyotrophic lateral sclerosis is a rapidly progressive and fatal disease. Although astrocytes are increasingly recognized contributors to the underlying pathogenesis, the cellular autonomy and uniformity of astrocyte reactive transformation in different genetic forms of amyotrophic lateral sclerosis remain unresolved.
Here we systematically examine these issues by using highly enriched and human induced pluripotent stem cell-derived astrocytes from patients with VCP and SOD1 mutations.
We show that VCP mutant astrocytes undergo cell-autonomous reactive transformation characterized by increased expression of complement component 3 (C3) in addition to several characteristic gene expression changes. We then demonstrate that isochronic SOD1 mutant astrocytes also undergo a cell-autonomous reactive transformation, but that this is molecularly distinct from VCP mutant astrocytes. This is shown through transcriptome-wide analyses, identifying divergent gene expression profiles and activation of different key transcription factors in SOD1 and VCP mutant human induced pluripotent stem cell-derived astrocytes. Finally, we show functional differences in the basal cytokine secretome between VCP and SOD1 mutant human induced pluripotent stem cell-derived astrocytes.
Our data therefore reveal that reactive transformation can occur cell autonomously in human amyotrophic lateral sclerosis astrocytes and with a striking degree of early molecular and functional heterogeneity when comparing different disease-causing mutations. These insights may be important when considering astrocyte reactivity as a putative therapeutic target in familial amyotrophic lateral sclerosis.
Genome sequencing identifies rare tandem repeat expansions and copy number variants in Lennox–Gastaut syndrome
Authors: Qaiser Farah , Sadoway Tara , Yin Yue , Zulfiqar Ali Quratulain , Nguyen Charlotte M , Shum Natalie , Backstrom Ian , Marques Paula T , Tabarestani Sepideh , Munhoz Renato P , Krings Timo , Pearson Christopher E , Yuen Ryan K C , Andrade Danielle M 
Published: September 2021

AbstractEpilepsies are a group of common neurological disorders with a substantial genetic basis. Despite this, the molecular diagnosis of epilepsies remains challenging due to its heterogeneity. Studies utilizing whole-genome sequencing may provide additional insights into genetic causes of epilepsies of unknown aetiology. Whole-genome sequencing was used to evaluate a cohort of adults with unexplained developmental and epileptic encephalopathies (n = 30), for whom prior genetic tests, including whole-exome sequencing in some cases, were negative or inconclusive. Rare single nucleotide variants, insertions/deletions, copy number variants and tandem repeat expansions were analysed. Seven pathogenic or likely pathogenic single nucleotide variants, and two pathogenic deleterious copy number variants were identified in nine patients (32.1% of the cohort). One of the copy number variants, identified in a patient with Lennox–Gastaut syndrome, was too small to be detected by chromosomal microarray techniques. We also identified two tandem repeat expansions with clinical implications in two other patients with Lennox–Gastaut syndrome: a CGG repeat expansion in the 5′untranslated region of DIP2B, and a CTG expansion in ATXN8OS (previously implicated in spinocerebellar ataxia type 8). Three patients had KCNA2 pathogenic variants. One of them died of sudden unexpected death in epilepsy. The other two patients had, in addition to a KCNA2 variant, a second de novo variant impacting potential epilepsy-relevant genes (KCNIP4 and UBR5). Overall, whole-genome sequencing provided a genetic explanation in 32.1% of the total cohort. This is also the first report of coding and non-coding tandem repeat expansions identified in patients with Lennox–Gastaut syndrome. This study demonstrates that using whole-genome sequencing, the examination of multiple types of rare genetic variation, including those found in the non-coding region of the genome, can help resolve unexplained epilepsies.