bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis and assessment of defectiveness of regulations for the yellow signal at the intersection
Authors: Olejnik Krzysztof 
Published: February 2021

Abstract
Imprecise and defective regulations should be eliminated in the operation of vehicles. The article discusses and evaluates the differences in legal acts regarding the requirements for the yellow signal at intersections with traffic lights. Poland has signed the Vienna Convention on signs and signals. When implementing it into Polish legislation, the original provision was changed slightly. The reason for the ban on entering the intersection during the yellow signal has been changed. As a result, an unfavorable situation arises for the driver without a good way out. In addition, a colloquial word was introduced, undefined – “rapid braking”. The changes introduced in relation to the Vienna Convention were analyzed and evaluated. Defects were found and the need and necessity of correction of the applicable provision were reported. The necessity to consider changing the provision in the Vienna Convention was also pointed out. There is a need to provide advance information about an upcoming change. These are activities in the operation of vehicles in road traffic from the area of active safety system. It may be possible to use e.g. a flashing signal in the final phase of displaying a solid green signal on the S1 signaling device for vehicles.
Identifying Innovative Reliable Criteria Governing the Selection of Infrastructures Construction Project Delivery Systems
Authors: Nouh Meshref Ahmed , Elkasaby E.A. , Wageh Omnia 
Published: February 2021

Abstract
No doubt that the most vital issues to achieve a great success project are the choice of best suitable project delivery methods. According to the experience of project management staff, the delivery of the project is chosen. However, that leads to similar repetitive issues, for example, exceeding the cost of the project and exceeding the project's schedule, and that's what many projects face. It is difficult to develop the management of the recurring issues of the project because there is no awareness of delivery methods. The efficiency of project implementation is greatly affected by selecting the appropriate delivery method. Fuzzy data at early stages of construction projects leads to the fuzzy decision of selection a suitable type to deliver the project contract. In this study, the main purpose was to determine the comprehensive criteria that significantly influence the selection of infrastructures construction project delivery systems. These criteria will aid decision making process more comprehensive and effective innovation tool to choose the reliable Infrastructures Project Delivery System.
Piroxicam reduces acute and chronic pain response in type 1 diabetic rats
Authors: Alimoradian Abbas , Samimi Fatemeh , Aslfalah Hadise , Latifi Seied Amirhossein , Salehi Mehdi , Khodaei Maryam , Amri Jamal 
Published: February 2021

Abstract

Objectives
Pain associated with various underlying pathologies is a major cause of morbidity and diminished life quality in diabetic patients. Effective control of pain requires the use of analgesics with the best efficacy and with minimal side effects. Therefore, our aim in this study was to investigate the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on pain in diabetic rats.

Methods
In this study, we investigated the analgesic effects of drugs belonging to three different classes of NSAIDs in a rat model of diabetes. Four diabetic groups received normal saline, diclofenac, piroxicam and ketorolac, respectively, and four non-diabetic groups received normal saline, diclofenac, piroxicam and ketorolac. Type 1 diabetes was induced in rats by a single injection of streptozotocin (60 mg/kg bw). Formalin (50 µL of 2.5%) nociception assay was used to examine the effect of treatment with diclofenac, piroxicam and ketorolac on acute and chronic pain in healthy and diabetic rats.

Results
Piroxicam showed significant analgesic effects both in the acute phase of pain (5–10 min after injection of formalin into the left hind paw), and in the chronic phase (20–60 min after formalin injection) in healthy as well as diabetic rats. Diclofenac and ketorolac also reduced pain scores in healthy rats. However, these two drugs failed to diminish pain in diabetic rats.

Conclusion
Our data point for better efficacy of piroxicam in controlling pain in diabetes.
Anti-inflammatory and analgesic effects of methanol extract of red cultivar Allium cepa bulbs in rats and mice
Authors: Oyewusi Adeoye Joshua , Oridupa Olayinka Ayotunde , Saba Adebowale Bernard , Oyewusi Ibironke Kofoworola , Olukunle Jonny Olufemi 
Published: February 2021

Abstract

Objectives
Several cultivars of Allium cepa L. have been studied for anti-inflammatory and analgesic activities but there is inadequate information on such biological activities of the concentrated extracts of the Nigerian grown red cultivar A. cepa bulb.

Methods
The anti-inflammatory models used in this study were Carrageenan-induced paw oedema and formalin-induced paw lick in rats, while acetic acid-induced abdominal writhing, hot plate reaction, hot water tail flick tests in mice were the analgesic models.

Results
At 30 min post-induction (pi), the inhibition of paw oedema (62.50%) by 200 mg/kg of methanol extract of red cultivar A. cepa bulb (MERCACB) was significantly (p<0.001) higher than that of indomethacin (15.63%) at 10 mg/kg. The paw oedema inhibition at 60 min pi by MERCACB (76.92%) was significantly higher than that of indomethacin (41.03%). At the early phase of formalin paw-lick test, the pain reaction time (PRT) of rat treated with MERCACB (400 mg/kg) was significantly lower than that of indomethacin and the control groups. The hotplate test revealed that PRT of mice treated with 800 mg/kg of MERCACB were significantly (p<0.01) longer in comparism to indomethacin and control groups. The PRT of mice subjected to thermal pain due to hot water and treated with 800 mg/kg of MERCACB was significantly (p<0.05) longer than that of the control group.

Conclusions
These findings indicate that MERCACB possesses potent anti-inflammatory and analgesic properties which confirm the traditional use of the plant for the treatment of inflammatory diseases and may be useful as a future therapeutic agent.
Pharmacological investigations on efficacy of Phlorizin a sodium-glucose co-transporter (SGLT) inhibitor in mouse model of intracerebroventricular streptozotocin induced dementia of AD type
Authors: Rani Reena , Kumar Amit , Jaggi Amteshwar Singh , Singh Nirmal 
Published: February 2021

Abstract

Objectives
The study has been commenced to discover the potential of Phlorizin (dual SGLT inhibitor) in streptozotocin induced dementia of Alzheimer’s disease (AD) type.

Material and methods
Injection of Streptozotocin (STZ) was given via i.c.v. route (3 mg/kg) to induce dementia of Alzheimer’s type. In these animals learning and memory was evaluated using Morris water maze (MWM) test. Glutathione (GSH) and thiobarbituric acid reactive species (TBARS) level was quantified to evaluate the oxidative stress; cholinergic activity of brain was estimated in term of acetylcholinesterase (AChE) activity; and the levels of myeloperoxidase (MPO) were measured as inflammation marker.

Results
The mice model had decreased performance in MWM, representing impairment of cognitive functions. Biochemical evaluation showed rise in TBARS level, MPO and AChE activity, and fall in GSH level. The histopathological study revealed severe infiltration of neutrophils. In the study, Phlorizin/Donepezil (serving as positive control) treatment mitigate streptozotocin induced cognitive decline, histopathological changes and biochemical alterations.

Conclusions
The results suggest that Phlorizin decreased cognitive function via its anticholinesterase, antioxidative, antiinflammatory effects and probably through SGLT inhibitory action. It can be conferred that SGLTs can be an encouraging target for the treatment of dementia of AD.
Design of 16 × 40 Gbps hybrid PDM-WDM FSO communication system and its performance comparison with the traditional model under diverse weather conditions of Bangladesh
Authors: Choyon A. K. M. Sharoar Jahan , Chowdhury Ruhin 
Published: February 2021

Abstract
A comprehensive design is proposed for free-space optical (FSO) communication system by hybridizing polarization division multiplexing (PDM) with wavelength division multiplexing (WDM) and its performance is investigated under diverse turbulent weather conditions of Bangladesh. Here we consider gamma–gamma (G–G) distribution for the turbulent FSO channel model. Moreover, a PDM-WDM technique not only maximizes the link capacity of FSO system but also enhances the spectral efficiency (SE) of the system. Besides, the performance of this hybrid PDM-WDM FSO system is compared with the traditional model and the proposed hybrid system exhibits excellent performance under diverse atmospheric conditions of Bangladesh. Performance analysis of the proposed model as well as the comparison with the traditional model is described in terms of optical power spectrum (OPS), optical signal to noise ratio (OSNR), bit error rate (BER), Q factor, constellation diagrams, and eye diagrams.
The crystal structure of pentakis(carbonyl)-{μ-[2,3-bis(sulfanyl)propan-1-olato]}-(triphenylphosphane)diiron (Fe–Fe)C26H21Fe2O6PS2
Authors: Gao Wei , Bai Yan-Jie , Mao Jia-Le , Guo Xue-Quan 
Published: February 2021

Abstract
C26H21Fe2O6PS2, monoclinic, P21/c (no. 14), a = 9.0892(6) Å, b = 27.6631(18) Å, c = 11.3409(8) Å, β = 106.409(2)°, V = 2735.4(3) Å3, Z = 4, R

gt
(F) = 0.0670, wR

ref
(F
2) = 0.1620, T = 296(2) K.
Narratives of undergraduate research, mentorship, and teaching at UCLA
Authors: Stevens Simone L. , Phung Alice C. , Gonzalez Alejandra , Shao Yanwu , Moully Elamar Hakim , Nguyen Vinh T. , Martin Joshua L. , Mao Chantel , Saebi Azin , Mosallaei Daniel , Kirollos Monica , Chong Paul , Umanzor Alexander , Qian Kevin , Marin Gustavo , Ebrahim Omar M. , Pathuri Ramya S. , Hopp Morgan , Ramachandran Roshini , Waddington Mary A. , Spokoyny Alexander M. 
Published: February 2021

Abstract
This work describes select narratives pertaining to undergraduate teaching and mentorship at UCLA Chemistry and Biochemistry by Alex Spokoyny and his junior colleagues. Specifically, we discuss how individual undergraduate researchers contributed and jump-started multiple research themes since the conception of our research laboratory. This work also describes several recent innovations in the inorganic and general chemistry courses taught by Spokoyny at UCLA with a focus of nurturing appreciation for research and creative process in sciences including the use of social media platforms.
Magnetic particle imaging of particle dynamics in complex matrix systems
Authors: Draack Sebastian , Schilling Meinhard , Viereck Thilo 
Published: February 2021

Abstract
Magnetic particle imaging (MPI) is a young imaging modality for biomedical applications. It uses magnetic nanoparticles as a tracer material to produce three-dimensional images of the spatial tracer distribution in the field-of-view. Since the tracer magnetization dynamics are tied to the hydrodynamic mobility via the Brownian relaxation mechanism, MPI is also capable of mapping the local environment during the imaging process. Since the influence of viscosity or temperature on the harmonic spectrum is very complicated, we used magnetic particle spectroscopy (MPS) as an integral measurement technique to investigate the relationships. We studied MPS spectra as function of both viscosity and temperature on model particle systems. With multispectral MPS, we also developed an empirical tool for treating more complex scenarios via a calibration approach. We demonstrate that MPS/MPI are powerful methods for studying particle-matrix interactions in complex media.
Durability of geopolymers and geopolymer concretes: A review
Authors: Lingyu Tian , Dongpo He , Jianing Zhao , Hongguang Wang 
Published: February 2021

Abstract
Geopolymers are green materials with three-dimensional silicon and aluminum tetrahedral structures that can be serving as environmentally friendly construction materials and therefore have the potential to contribute to sustainable development. In this paper, the mechanism and research progress regarding the carbonation resistance, structural fire resistance, corrosion resistance, permeation properties and frost resistance of geopolymer concretes are reviewed, and the main problems with the durability of geopolymer concretes are discussed. Geopolymers possess the superb mechanic property and their compression strengths could be higher than 100 MPa. Generally, the higher the GPC strength, the better the carbonation-resistant. GPC has excellent fire resistance, due to geopolymers are acquired an inorganic skeleton which is affected by the alkali content, alkali cation, and Si/Ai ratio. There are a large number of Al-O and Si-O structures in geopolymers. Geopolymers do not react with acids at room temperature and can be used to make acid-resistant materials. Besides, GPC owning low porosity volume shows good resistance to permeability. The freezing-thawing failure mechanism of geopolymer concretes is mainly based on hydrostatic and osmotic pressure theory. GPC has poor frost resistance, and the freezing-thawing limit is less than 75 times.
Study of surfaces, produced with the use of granite and titanium, for applications with solar thermal collectors
Authors: Alves Albuquerque Araújo Felipe , Nivaldo Aguiar Freire Francisco , Caitano Pinho Diego , Dutra Kaio Hemerson , Rocha Paulo Alexandre Costa , Vieira da Silva Maria Eugênia 
Published: February 2021

Abstract
The present work consisted in obtaining and studying selective surfaces for applications in low-cost flat plate solar collectors, using residues from the granite industry. Five different surfaces were studied, varying the percentage by weight: 100% granite powder, 75% granite powder + 25% titanium oxide, 50% granite powder + 50% titanium oxide, 25% granite powder + 75% titanium oxide and 100% titanium oxide.
For the tests, an experimental wooden bench was built, and it was possible to simulate the conditions of a flat plate solar collector. For characterization of the surfaces, SEM techniques, infrared analysis and UV-VIS absorbance determination were used, as well as graphs with surface temperatures and with radiation in the sun tests.
The efficiency of the surfaces was determined by the ratio of the absorptivity through the emissivity, as well as the trademark MRTiNOX. An efficiency of 23.58 was obtained for this, while for the 50% granite - 50% titanium surface the value of 23.30 (closest to the trade mark) was calculated. Therefore, replacing the traditional components of selective surfaces with granite proved to be a satisfactory solution, contributing to the reduction of costs with solar energy.
Xanthene based resonance Rayleigh scattering and spectrofluorimetric probes for the determination of cyclobenzaprine: Application to content uniformity test
Authors: Abdel-Lateef Mohamed A. , Almahri Albandary , Derayea Sayed M. , Samir Ebtihal 
Published: February 2021

Abstract
In this work, a resonance Rayleigh scattering technique and a spectrofluorimetric technique were applied to the quantification of cyclobenzaprine through two validated methods. The suggested methods are based on a facile association complex formation between cyclobenzaprine and eosin Y reagent in the acidic medium. The resonance Rayleigh scattering method relied on the enhancement in the resonance Rayleigh scattering spectrum of eosin Y at 370 nm after the addition of cyclobenzaprine. On the other hand, the spectrofluorimetric quantification relied on the quenching effect of cyclobenzaprine on the fluorescence strength of the eosin Y reagent at 545 nm (excitation wavelength at 300 nm). The suggested methods were linear over the ranges of 0.07–1.75 μg/mL and 0.15–2.0 μg/mL with detection limit values of 0.023 μg/mL and 0.048 μg/mL for the resonance Rayleigh scattering method and the spectrofluorimetric method, respectively. All reaction conditions for cyclobenzaprine–eosin Y formation were experimentally evaluated and optimized. In addition, both methods were validated based on ICH rules. Furthermore, the developed methods were practically applied to the analysis of cyclobenzaprine in its commercial tablet dosage form with acceptable recoveries. Moreover, the content uniformity test of the commercial cyclobenzaprine tablets was successfully applied using the proposed spectroscopic methods based on USP rules.
The role of PKMζ in the maintenance of long-term memory: a review
Authors: Patel Hamish , Zamani Reza 
Published: February 2021

Abstract
Long-term memories are thought to be stored in neurones and synapses that undergo physical changes, such as long-term potentiation (LTP), and these changes can be maintained for long periods of time. A candidate enzyme for the maintenance of LTP is protein kinase M zeta (PKMζ), a constitutively active protein kinase C isoform that is elevated during LTP and long-term memory maintenance. This paper reviews the evidence and controversies surrounding the role of PKMζ in the maintenance of long-term memory. PKMζ maintains synaptic potentiation by preventing AMPA receptor endocytosis and promoting stabilisation of dendritic spine growth. Inhibition of PKMζ, with zeta-inhibitory peptide (ZIP), can reverse LTP and impair established long-term memories. However, a deficit of memory retrieval cannot be ruled out. Furthermore, ZIP, and in high enough doses the control peptide scrambled ZIP, was recently shown to be neurotoxic, which may explain some of the effects of ZIP on memory impairment. PKMζ knockout mice show normal learning and memory. However, this is likely due to compensation by protein-kinase C iota/lambda (PKCι/λ), which is normally responsible for induction of LTP. It is not clear how, or if, this compensatory mechanism is activated under normal conditions. Future research should utilise inducible PKMζ knockdown in adult rodents to investigate whether PKMζ maintains memory in specific parts of the brain, or if it represents a global memory maintenance molecule. These insights may inform future therapeutic targets for disorders of memory loss.
Numerical stochastic modelling of spatial and spatio-temporal fields of the wind chill index in the South of Western Siberia
Authors: Kargapolova Nina A. , Ogorodnikov Vasily A. 
Published: February 2021

Abstract
The paper presents the results of comparison of various methods of spatial interpolation of the wind chill index in two regions located in the South of Western Siberia (Russia). It is shown that stochastic interpolation provides the least interpolation error in the considered regions. The results of modelling the spatial and spatio-temporal fields of the considered bioclimatic index on a regular grid are presented.
Real time defect detection during composite layup via Tactile Shape Sensing
Authors: Elkington Michael , Almas Even , Ward-Cherrier Ben , Pestell Nick , Lloyd J. , Ward Carwyn , Lepora Nathan 
Published: February 2021

Abstract
In this study an automated composite layup end effector is presented which is the first to be able to find defects in real time during layup using tactile shape sensing. Based around an existing sensor concept developed by the Bristol Robot Laboratory known as the ‘TacTip’, a new end effector is developed, replacing the soft gel core of the original sensor was replaced by a much firmer elastomer, enabling it to apply up to 400N of compaction force. In this paper it is shown to successfully detect typical defects such as wrinkles, foreign objects, layup errors or incorrect material types while simultaneously compacting preimpregnated composite materials over complex mould shapes.
Cushioning energy absorption of paper corrugation tubes with regular polygonal cross-section under axial static compression
Authors: Kang Jianfen , Guo Yanfeng , Fu Yungang , Li Qiong , Lv Yabo 
Published: February 2021

Abstract
The paper corrugation tube is an innovative kind of energy absorbing structure and shock absorber which can play an important role on the cushioning energy absorption for airdrop equipments and transportation packaging. The deformation characteristics and failure modes of the regular triangle, quadrangle, pentagon and hexagon paper corrugation tubes were comparatively studied by a series of axial static compression experiments, the cushioning energy absorption was evaluated by the seven characteristic parameters (e.g. initial peak force, mean crush force, total energy absorption, specific energy absorption, crush force efficiency, unit area energy absorption and stroke efficiency), and the influences of tube direction, cross-sectional shape, tube length and compression rate on failure modes and cushioning energy absorption were analyzed and compared. These researches showed that the tubes along X direction only have the accordion deformation mode, yet the tubes along Y direction have four deformation modes including steady state progressive buckling, Euler buckling, angular tear and transverse shear. For the paper corrugation tubes along Y direction, the cross-sectional shape has obvious influence on the cushioning energy absorption of structures, and the specific energy absorption and unit area energy absorption of regular triangle and pentagon tubes are better than those of the tubes with regular quadrilateral and hexagonal cross-section at compression rates of 12 and 48mm/min. The tube length of 150 mm or compression rate of 72 mm/min would cause the increase of contribution proportion of non-ideal deformation mode and the decrease of cushioning properties. The paper corrugation tubes along X direction have more stable and controllable deformation mode, yet the paper corrugation tubes along Y direction have better cushioning energy absorption.
Measuring diagram quality through semiotic morphisms
Authors: Marshall Guy Clarke , Freitas André 
Published: February 2021

Abstract
This paper outlines a method to assess the effectiveness of diagrams, from semiotic foundations. In doing so, we explore the Peircian notion of signification, as applied to diagrammatic representations. We review a history of diagrams, with particular emphasis on schematics used for representing systems, and uncover the neglect of semiotic analysis of diagrammatic representations. Through application of category theory to the Peircian triadic model, we propose a set of quantitative quality measures for diagrams, and a framework for their assessment, based on the properties of their encoding, pragmatic and perceptual morphisms. These measures include diagram complexity, utility, aesthetics and expert assessment of semiotic content, together with qualitative feedback. We consider the diagrams as an aid to cognitive processes, rather than a purely communication media. This utility-focused perspective on diagram quality dimensions allows for fresh insights into the creation of effective diagrams.