bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nudging the N170 forward with prior stimulation—Bridging the gap between N170 and recognition potential
Authors: Luo Canhuang , Chen Wei , VanRullen Rufin , Zhang Ye , Gaspar Carl Michael 
Published: November 2021

AbstractEvoked response potentials are often divided up into numerous components, each with their own body of literature. But is there less variety than we might suppose? In this study, we nudge one component into looking like another. Both the N170 and recognition potential (RP) are N1 components in response to familiar objects. However, the RP is often measured with a forward mask that ends at stimulus onset whereas the N170 is often measured with no masking at all. This study investigates how inter‐stimulus interval (ISI) may delay and distort the N170 into an RP by manipulating the temporal gap (ISI) between forward mask and target. The results revealed reverse relationships between the ISI on the one hand, and the N170 latency, single‐trial N1 jitter (an approximation of N1 width) and reaction time on the other hand. Importantly, we find that scalp topographies have a unique signature at the N1 peak across all conditions, from the longest gap (N170) to the shortest (RP). These findings prove that the mask‐delayed N1 is still the same N170, even under conditions that are normally associated with a different component like the RP. In general, our results suggest greater synthesis in the study of event related potential components.
Effect of diabetes medications and glycemic control on risk of hepatocellular cancer in patients with nonalcoholic fatty liver disease
Authors: Kramer Jennifer R. , Natarajan Yamini , Dai Jianliang , Yu Xian , Li Liang , El‐Serag Hashem B. , Kanwal Fasiha 
Published: November 2021

Abstract

Background and Aims
In patients with NAFLD, those with type 2 diabetes mellitus (DM) have a high risk of progression to HCC. However, the determinants of HCC risk in these patients remain unclear.

Approach and Results
We assembled a retrospective cohort of patients with NAFLD and DM diagnosed at 130 facilities in the Veterans Administration between 1/1/2004 and 12/31/2008. We followed patients from the date of NAFLD diagnosis to HCC, death, or 12/31/2018. We used landmark Cox proportional hazards models to determine the effects of anti‐DM medications (metformin, insulin, sulfonylureas) and glycemic control (percent of follow‐up time with hemoglobin A1c < 7%) on the risk of HCC while adjusting for demographics and other metabolic traits (hypertension, obesity, dyslipidemia). We identified 85,963 patients with NAFLD and DM. In total, 524 patients developed HCC during a mean of 10.3 years of follow‐up. Most common treatments were metformin monotherapy (19.7%), metformin‐sulfonylureas (19.6%), insulin (9.3%), and sulfonylureas monotherapy (13.6%). Compared with no medication, metformin was associated with 20% lower risk of HCC (HR, 0.80; 95% CI, 0.93–0.98). Insulin had no effect on HCC risk (HR, 1.02; 95% CI, 0.85–1.22; p = 0.85). Insulin in combination with other oral medications was associated with a 1.6 to 1.7‐fold higher risk of HCC. Adequate glycemic control was associated with a 31% lower risk of HCC (HR, 0.69; 95% CI, 0.62–0.78).

Conclusions
In this large cohort of patients with NAFLD and DM, use of metformin was associated with a reduced risk of HCC, whereas use of combination therapy was associated with increased risk. Glycemic control can serve as a biomarker for HCC risk stratification in patients with NAFLD and diabetes.
Changes in surface wind speed and its different grades over China during 1961–2020 based on a high‐resolution dataset
Authors: Wu Jie , Shi Ying 
Published: November 2021

AbstractChanges in surface wind speed are important for wind energy planning, especially in China, which has the highest new and total wind power capacities globally. In this article, based on a daily high‐resolution observation dataset for the period of 1961–2020, changes in the surface wind speed and its different grades over China were analysed. The results showed that following significant declines from 1961 to 2002, the annual and seasonal mean surface wind speeds began to increase over China and most of its subregions (all subregions except for East China) after 2002. Opposite trends were found in the probabilities for most different grades of surface wind speed from 1961 to 2002 and from 2002 to 2020. In addition, we compared the results with those from NCEP‐1, JRA‐55, and ERA5, which showed that all of the reanalysis data could reasonably reproduce the observed spatial distributions of the surface wind speed and its different grades, although with bias in values and smaller interannual variabilities. The wind reversal over China was closely related to changes in the trends of the sea level pressure gradient. Moreover, the variation in the Pacific Decadal Oscillation (PDO) has a significantly negative correlation coefficient with the surface wind speed over East, Central, and South China.
Effects of chitosan and apple polyphenol coating on quality and microbial composition of large yellow croaker (Pseudosciaena crocea) during ice storage
Authors: Lan Weiqing , Zhao Xinyu , Wang Meng , Xie Jing 
Published: November 2021

AbstractBACKGROUNDLarge yellow croaker (Pseudosciaena crocea) has important commercial value because of its high nutritional value and delicious taste. However, large yellow croaker is readily affected by microorganisms during storage, which causes the corruption of muscle tissue. Both chitosan (CS) and apple polyphenols (APs) are bio‐preservatives, which can effectively inhibit the growth of microorganisms and improve the quality of large yellow croaker. The effects of 10.0 and 20.0 g L–1 CS combined with 1.0 g L–1 AP coating on the quality and microbial composition of large yellow croaker during ice storage were investigated respectively.RESULTSCS + AP coating restrained the increase of total volatile basic nitrogen (TVB‐N) and biogenic amines, slowed down the rise of K‐value and retarded the growth of microorganisms. The bacteriostatic effect was positively correlated with the concentration of CS. Through the analysis of high‐throughput sequencing (HTS), the microbial diversity was changed respectively. The proportion of Shewanella was significantly decreased by CS + AP coating treatment and Pseudomonas was the dominant microorganism in spoiled samples. Compared with the shelf‐life of the control group (8 days), 20.0 g L–1 CS combined with 1.0 g L–1 AP coating treatment could extend the shelf‐life of large yellow croaker for another 8 days.CONCLUSIONSCS combined with AP coating may be considered a promising method to delay the biochemical changes of ice stored large yellow croaker and extend its shelf life. © 2021 Society of Chemical Industry.
Lactobacillus paracasei M11‐4 isolated from fermented rice demonstrates good antioxidant properties in vitro and in vivo
Authors: Yang Jianjun , Dong Chenyang , Ren Fazheng , Xie Yuanhong , Liu Hui , Zhang Hongxing , Jin Junhua 
Published: November 2021

AbstractBACKGROUNDProbiotics are defined as microorganisms that can exert health benefits for the host. Among the recognized probiotics, Lactobacillus paracasei are one of the most frequently used probiotics in humans. The L. paracasei strain M11‐4, isolated from fermented rice (which could ferment soymilk within a short curd time) and fermented soymilk presented high viability, acceptable flavor, and antioxidant activity, which revealed that the strain maybe have a potential antioxidant value. Therefore, it is necessary to further explore the antioxidant activity of L. paracasei strain M11‐4.RESULTSThe radical scavenging activities, lipid peroxidation inhibition, and reducing power of L. paracasei M11‐4 were the highest in the fermentation culture without cells, whereas the activities of other antioxidant enzymes of L. paracasei M11‐4 were high in the cell‐free extract and bacterial suspension. Moreover, L. paracasei M11‐4 exerted its antioxidant effect by upregulating the gene expression of its antioxidant enzymes – the thioredoxin and glutathione systems – when hydrogen peroxide existed. Supplementation of rats with L. paracasei M11‐4 effectively alleviated d‐galactose‐induced oxidative damage in the liver and serum and prevented d‐galactose‐induced changes to intestinal microbiota. Supplementation with L. paracasei M11‐4 also reduced the elevated expression of thioredoxin and glutathione system genes induced by d‐galactose.CONCLUSIONL. paracasei M11‐4 has good antioxidant properties both in vitro and in vivo, and its antioxidant mechanism was studied at the molecular level. © 2021 Society of Chemical Industry.
Response of a tropical cyclone to a subsurface ocean eddy and the role of boundary layer dynamics
Authors: Kumar Arjun U. , Brüggemann Nils , Smith Roger K. , Marotzke Jochem 
Published: November 2021

AbstractWe analyse a tropical cyclone simulated for a realistic ocean‐eddy field using the global, nonhydrostatic, fully coupled atmosphere–ocean ICOsahedral Nonhydrostatic (ICON) model. After intensifying rapidly, the tropical cyclone decays following its interaction with a cold wake and subsequently reintensifies as it encounters a subsurface, warm‐core eddy. To understand the change in the azimuthal‐mean structure and intensity of the tropical cyclone, we invoke a conceptual framework, which recognises the importance of both boundary‐layer dynamics and air–sea interactions. Crucially, the framework recognises that the change in the mean radius of updraught at the boundary‐layer top is regulated by the expanding outer tangential wind field through boundary‐layer dynamics. The decrease in the average equivalent potential temperature of the boundary‐layer updraught during the early decay phase is related to an increase in the mean radius of the updraught rather than air–sea interactions. However, later in the decay phase, air–sea interactions contribute to the decrease, which is accompanied by a decrease in the vertical mass flux in the eyewall updraught and, ultimately, a more pronounced spin‐down of the tropical cyclone. Air–sea interactions are also important during reintensification, where the tendencies are reversed, that is, the mean radius of the boundary‐layer updraught decreases along with an increase in its average equivalent potential temperature and vertical mass flux. The importance of boundary‐layer dynamics to the change in the azimuthal‐mean structure is underscored by the ability of a steady‐state slab boundary‐layer model to predict an increasing and, to a lesser extent, decreasing radius of forced ascent for periods of decay and reintensification, respectively. Finally, our simulation highlights the importance of the ocean‐eddy field for tropical cyclone intensity forecasts, since the simulated warm‐core eddy does not display any sea‐surface temperature (SST) signal until it is encountered by the tropical cyclone.
Nested analysis of macroinvertebrate diversity along a river continuum: Identifying relevant spatial scales for stream communities
Authors: Doretto Alberto , Receveur Joseph P. , Baker Edward A. , Benbow M. Eric , Scribner Kim T. 
Published: November 2021

AbstractBenthic macroinvertebrates are important for stream ecosystem function and are considerable food resources for vertebrate consumers such as fish. The diversity, composition, and distribution of stream macroinvertebrate taxa are affected by factors that act at different spatial scales, from microhabitat to watershed‐level effects. While comparative studies of watershed‐level and between stream influences on benthic diversity are common, the effects of scale are less investigated within individual river segments. Benthic macroinvertebrates were systematically sampled across nested spatial scales along a 2.2‐km near‐pristine stretch of the Upper Black River (MI, USA), and analyzed in relation to near‐bed flow and substrate features. Responses of community diversity metrics to near‐bed conditions were quantified, and diversity was modeled to determine the contribution of each spatial scale to total diversity. Near‐bed conditions, especially Froude number and substrate size, were positively associated with macroinvertebrate diversity and abundance. Larger (e.g., 100 m stream reach) and finer scales (e.g., individual samples) accounted for a greater proportion of variation in taxon richness and abundance, respectively. Longitudinal variation in environmental conditions was an important driver of macroinvertebrate diversity, with replacement between sites (i.e., turnover) contributing a considerably greater proportion of variation in total diversity than nestedness. Results demonstrate that macroinvertebrate communities were shaped by both local flow and substrate conditions as well as taxa replacement over larger spatial scales. This emphasizes the importance of maintaining the hydro‐morphological integrity along stream courses as a requisite condition to further watershed and fisheries conservation and management.
Life‐cycle assessment of full‐scale membrane bioreactor and tertiary treatment technologies in the fruit processing industry
Authors: Chu Tong , Abbassi Bassim E. , Zytner Richard G. 
Published: November 2021

AbstractA life‐cycle assessment (LCA) study was completed to assess the environmental impacts of an on‐site wastewater treatment system in the fresh‐cut fruit processing industry consisting of a membrane bioreactor (MBR), followed by reverse osmosis (RO) and ultraviolet (UV) disinfection. The system boundaries comprised raw materials extraction and processing, transportation, construction, operation, and waste disposal. SimaPro 8.0.4.26 was used as the software tool, supported by two impact assessment methods (ReCiPe v1.11 and TRACI v2.1). Analysis showed that the treatment capacity of the MBR and tertiary technologies contributed the least damage to the ecosystem when compared with the other three scenarios and can provide water for reuse. Treating wastewater in municipal wastewater treatment plants (WWTPs) mitigated eutrophication like the MBR system but resulted in more environmental impacts from climate change and human health when compared with the on‐site treatment system. Findings will be informative to stakeholders in the fresh‐cut agri‐food sector seeking input into selecting the appropriate treatment approach, with water reuse a goal.Practitioner Points
Life‐cycle analysis was completed on a fruit processing facility using MBR + RO + UV.
On site treatment with MBR + RO UV provides least amount of environmental impact.
Use of MBR + RO + UV treatment on fruit wastewater allows for water reuse.
ReCiPe v1.11 and TRACI v2.1 give similar LCA results, with TRACI recommended for North American analysis.
Factors Influencing Rapid Antiretroviral Therapy Initiation at Four eThekwini Clinics, KwaZulu-Natal, South Africa
Authors: Govere Sabina M. , Kalinda Chester , Chimbari Moses J. 
Published: November 2021

AbstractTimely uptake of Antiretroviral therapy considerably improves the health of people living with the Human Immunodeficiency virus. We conducted a cross-sectional study of newly HIV diagnosed individuals in four clinics in eThekwini municipality, KwaZulu-Natal. Data was collected between June 2020 and December 2020. Participants completed an interviewer-administered questionnaire after HIV testing, on the day of HIV diagnosis. We evaluated factors influencing uptake of same-day ART initiation in eThekwini clinics, KwaZulu Natal, South Africa. Demographic information, health status, sexual behaviour, knowledge of universal test and treat (UTT), ART initiation uptake, and disclosure data was collected. Among the 403 participants, same-day initiation (SDI) was 69.2% (n = 279). We observed the number of sexual partners (aOR 0.35; 95% CI 0.15–0.81), HIV status of the partner (aOR 5.03; 95% CI 2.74–9.26) and knowledge of UTT (aOR 1.97; 95% CI 1.34–2.90) were identified as major factors influencing uptake of same-day ART initiation. More strategies are needed to achieve the SDI uptake within the framework of UTT.
Machine learning approaches for parsing comorbidity/heterogeneity in antisociality and substance use disorders: A primer
Authors: Shane Matthew S. , Denomme William J. 
Published: November 2021

Abstract
By some accounts, as many as 93% of individuals diagnosed with antisocial personality disorder (ASPD) or psychopathy also meet criteria for some form of substance use disorder (SUD). This high level of comorbidity, combined with an overlapping biopsychosocial profile, and potentially interacting features, has made it difficult to delineate the shared/unique characteristics of each disorder. Moreover, while rarely acknowledged, both SUD and antisociality exist as highly heterogeneous disorders in need of more targeted parcellation. While emerging data-driven nosology for psychiatric disorders (e.g., Research Domain Criteria (RDoC), Hierarchical Taxonomy of Psychopathology (HiTOP)) offers the opportunity for a more systematic delineation of the externalizing spectrum, the interrogation of large, complex neuroimaging-based datasets may require data-driven approaches that are not yet widely employed in psychiatric neuroscience. With this in mind, the proposed article sets out to provide an introduction into machine learning methods for neuroimaging that can help parse comorbid, heterogeneous externalizing samples. The modest machine learning work conducted to date within the externalizing domain demonstrates the potential utility of the approach but remains highly nascent. Within the paper, we make suggestions for how future work can make use of machine learning methods, in combination with emerging psychiatric nosology systems, to further diagnostic and etiological understandings of the externalizing spectrum. Finally, we briefly consider some challenges that will need to be overcome to encourage further progress in the field.
A natural example of brittle-to-viscous strain localization under constant-stress conditions: a case study of the Kellyland fault zone, Maine, USA
Authors: Sullivan Walter A. , O’Hara Emma J. 
Published: November 2021

AbstractThis article integrates field, powder X-ray diffraction and microstructural data to constrain deformation mechanisms in and the rheology of granite-derived fault rocks exposed along the SE side of the crustal-scale, strike-slip Kellyland fault zone. Deformation in this area of the Kellyland fault zone localized during cooling and is marked by (1) foliated granite, (2) a ∼50 m wide band of pulverized foliated granite, (3) a ∼2.8 m wide breccia zone hosting coeval shear zones, and (4) a >100 m wide ultramylonite zone. The earliest fabric in the foliated granite is defined by elongated quartz grains, and quartz dislocation creep was the rate-controlling deformation mechanism. Seismogenic deformation initiated when recorded flow stresses reached 96–104 MPa at temperatures of 400–450 °C and is marked by coeval pulverization and formation of breccia. Interseismic viscous creep at similar flow stresses is recorded by mutual cross-cutting relationships between breccia-hosted shear zones, brittle fractures and pseudotachylyte. Field and microstructural observations indicate that breccia-hosted shear zones are low-strain equivalents of the >100 m wide ultramylonite zone, and seismogenic deformation abated as the ultramylonite formed. The rheology of ultramylonites was governed by grain-size-sensitive creep at 112–124 MPa flow stresses. Hence, from the onset of seismogenesis, the Kellyland fault zone was likely a constant-stress system wherein the rate-controlling mechanism shifted from episodic seismogenic slip and interseismic viscous creep to steady state grain-size-sensitive creep in ultramylonites derived from brittle fault rocks. Flow stresses recorded by these rocks also imply that the whole zone was relatively weak if the brittle–viscous transition and uppermost viscous zone are the strongest part of the crust.
A Geochemical Review of Amphibolite, Granulite, and Eclogite Facies Lithologies: Perspectives on the Deep Continental Crust
Authors: Sammon Laura G. , McDonough William F. 
Published: November 2021

AbstractDebate abounds regarding the composition of the deep (middle + lower) continental crust. Exhumed medium‐ and high‐grade metamorphic rocks, which range in composition from mafic to felsic, provide information about the bulk composition of the deep crust. This study presents a global compilation of geochemical data on amphibolite (n = 6,500), granulite (n = 4,000), and eclogite (n = 200) facies lithologies and quantifies trends, uncertainties, and sources of bias in the deep crust sampling. The continental crust's Daly Gap is well documented in amphibolite and most granulite facies lithologies. Igneous differentiation processes likely control the compositional layering in the crust. Al2O3, Lu, and Yb vary little from top to bottom of the crust. In contrast, SiO2, light rare earth elements, Th, and U show a wider range of abundances throughout. Because of oversampling of mafic lithologies, our predictions are a lower bound on middle crustal composition. Additionally, the distinction between granulite facies terrains (intermediate SiO2, high heat production, high incompatibles) or granulite facies xenoliths (low SiO2, low heat production, low incompatibles) as being the best analogs of the deep crust remains disputable. We have incorporated both rock types, along with amphibolite facies lithologies, to define a deep crustal composition that approaches 57.6 wt.% SiO2. This number, however, represents a compositional middle ground; the shallower parts of the deep crust (middle crust) resemble quartz monzonite while the deepest portions (lower crust) more resemble a Ca‐rich monzonite. Future studies should analyze more closely the depth dependent trends in deep crustal composition to develop composition models that are not limited to a three‐layer crust.
Stability of a Flow Over Bottom Topography: A General Condition and a Linear Analysis in a Two‐Layer Quasi‐Geostrophic Model With a Possible Application to a Kuroshio Meander
Authors: Tanaka Yuki 
Published: November 2021

AbstractThe stability of a two‐layer quasi‐geostrophic flow over bottom topography is examined by combining a method of obtaining a sufficient condition for stability and a linear stability analysis. First, using a conserved quantity called pseudoenergy that is proportional to the square of the disturbance amplitude, a sufficient condition for stability is derived for the simplest steady background field in which the potential vorticity and the stream function are proportional to each other. The theoretically obtained condition enables us to judge the stability of various background fields by explicitly taking into account the limitation imposed on the scale of the disturbance by the domain size and/or boundary conditions. Applying the stability condition to a special case of a sinusoidal background flow and topography then shows that the stable range extends to the area where the currents flow with shallower water on their right in both the upper and lower layers. The stable range is broadened as the disturbance becomes limited to smaller horizontal scales. A linear stability analysis shows that this broadening is mainly due to the suppression of barotropic instability that works effectively at large scales. Finally, a numerical simulation is performed with a realistic situation of a Kuroshio meander over a seamount south of Japan in mind. The results suggest that the theory is useful to identify a stable flow with negative‐definite pseudoenergy, which can be achieved under realistic ocean conditions where the scale of the disturbance is moderately restricted by a basin bounded by prominent topographic features.