bluuebunny/crossref_metadata_2025_split huggingface dataset:
Universal separability criterion for arbitrary density matrices from causal properties of separable and entangled quantum states
Authors: Skorobagatko Gleb A. 
Published: August 2021

AbstractGeneral physical background of famous Peres–Horodecki positive partial transpose (PH- or PPT-) separability criterion is revealed. Especially, the physical sense of partial transpose operation is shown to be equivalent to what one could call as the “local causality reversal” (LCR-) procedure for all separable quantum systems or to the uncertainty in a global time arrow direction in all entangled cases. Using these universal causal considerations brand new general relations for the heuristic causal separability criterion have been proposed for arbitrary $$ D^{N} \times D^{N}$$

D
N

×

D
N

density matrices acting in $$ {\mathcal {H}}_{D}^{\otimes N} $$

H

D

⊗
N

Hilbert spaces which describe the ensembles of N quantum systems of D eigenstates each. Resulting general formulas have been then analyzed for the widest special type of one-parametric density matrices of arbitrary dimensionality, which model a number of equivalent quantum subsystems being equally connected (EC-) with each other to arbitrary degree by means of a single entanglement parameter p. In particular, for the family of such EC-density matrices it has been found that there exists a number of N- and D-dependent separability (or entanglement) thresholds$$ p_{th}(N,D) $$

p

th

(
N
,
D
)

for the values of the corresponded entanglement parameter p, which in the simplest case of a qubit-pair density matrix in $$ {\mathcal {H}}_{2} \otimes {\mathcal {H}}_{2} $$

H
2

⊗

H
2

Hilbert space are shown to reduce to well-known results obtained earlier independently by Peres (Phys Rev Lett 77:1413–1415, 1996) and Horodecki (Phys Lett A 223(1–2):1–8, 1996). As the result, a number of remarkable features of the entanglement thresholds for EC-density matrices has been described for the first time. All novel results being obtained for the family of arbitrary EC-density matrices are shown to be applicable to a wide range of both interacting and non-interacting (at the moment of measurement) multi-partite quantum systems, such as arrays of qubits, spin chains, ensembles of quantum oscillators, strongly correlated quantum many-body systems with the possibility of many-body localization, etc.
Alterations in plasma hyaluronic acid in patients with clinically stable COPD versus (non)smoking controls
Authors: Waeijen-Smit Kiki , Reynaert Niki L. , Beijers Rosanne J. H. C. G. , Houben-Wilke Sarah , Simons Sami O. , Spruit Martijn A. , Franssen Frits M. E. 
Published: August 2021

AbstractHyaluronic acid (HA) is a key component of the extracellular matrix. HA and its metabolism are suggested to be altered in the lungs of patients with chronic obstructive pulmonary disease (COPD). The present study explored systemic HA, and its metabolic regulators, in patients with clinically stable COPD and smoking and non-smoking controls. Furthermore, associations of HA with acute exacerbations (AECOPD), airway-related hospitalizations, systemic inflammation and cardiovascular risk were studied. In total, 192 patients with moderate to very severe COPD [aged 62.3 y (± SD 7.0)], 84 smoking controls [aged 61.8 y (± 5.7)], and 107 non-smoking controls [aged 60.1 y (± 7.0)] were included. Plasma HA was reduced in patients with COPD compared to non-smoking controls (p = 0.033), but was comparable after adjusting for age and sex. Expression of HAS-3 did not differ between groups, but was substantially less detectable in more patients with COPD than (non)smoking controls (p < 0.001). Expression of HYAL-2 was enhanced in patients with COPD versus smoking (p = 0.019) and non-smoking (p < 0.001) controls, also in the age- and sex- adjusted model (p < 0.001). Plasma HA was not associated with AECOPD, airway-related hospitalizations in the previous year, or systemic inflammation in COPD. Arterial pulse wave velocity explained some of the variance (< 10%) in plasma HA (p = 0.006). Overall, these results indicate that expression of HYAL-2, but not plasma HA nor HAS-3, is enhanced in patients with COPD compared to (non)smoking controls. Furthermore, HA was not associated with clinical outcomes, yet, cardiovascular risk might play a role in its systemic regulation in stable COPD.
The phyllosphere microbiome of host trees contributes more than leaf phytochemicals to variation in the Agrilus planipennis Fairmaire gut microbiome structure
Authors: Mogouong Judith , Constant Philippe , Legendre Pierre , Guertin Claude 
Published: August 2021

AbstractThe microbiome composition of living organisms is closely linked to essential functions determining the fitness of the host for thriving and adapting to a particular ecosystem. Although multiple factors, including the developmental stage, the diet, and host-microbe coevolution have been reported to drive compositional changes in the microbiome structures, very few attempts have been made to disentangle their various contributions in a global approach. Here, we focus on the emerald ash borer (EAB), an herbivorous pest and a real threat to North American ash tree species, to explore the responses of the adult EAB gut microbiome to ash leaf properties, and to identify potential predictors of EAB microbial variations. The relative contributions of specific host plant properties, namely bacterial and fungal communities on leaves, phytochemical composition, and the geographical coordinates of the sampling sites, to the EAB gut microbial community was examined by canonical analyses. The composition of the phyllosphere microbiome appeared to be a strong predictor of the microbial community structure in EAB guts, explaining 53 and 48% of the variation in fungi and bacteria, respectively. This study suggests a potential covariation of the microorganisms associated with food sources and the insect gut microbiome.
“Ecce Homo” by Antonello da Messina, from non-invasive investigations to data fusion and dissemination
Authors: Albertin Fauzia , Ruberto Chiara , Cucci Costanza , Callieri Marco , Potenziani Marco , Siotto Eliana , Pingi Paolo , Scopigno Roberto , Bettuzzi Matteo , Brancaccio Rosa , Morigi Maria Pia , Castelli Lisa , Taccetti Francesco , Picollo Marcello , Stefani Lorenzo , de Vita Francesca 
Published: August 2021

AbstractScientific investigations of artworks are crucial in terms of preservation since they provide a measurable evaluation of the materials and the state of conservation. This is the case of Antonello da Messina’s painting “Ecce Homo”: its delicate state of conservation, with the need for constant monitoring, required a broad and in-depth diagnostic campaign to support the restorers. The project was carried out entirely in situ using non-invasive cutting-edge techniques and proposes a multimodal and data-centric approach, integrating 3D and 2D methodologies. The surface irregularities and the support were analysed with a structured-light 3D scanner and X-ray tomography. The painting materials were investigated with X-ray fluorescence scanning (MA-XRF) and reflectance hyperspectral imaging (HSI). Primarily, the data were jointly used for a scientific scope and provided new knowledge of the painting in terms of materials and painting techniques. In addition, two web-based interactive platforms were developed: one to provide restorers and experts with a new perspective of the hidden geometries of the painting, and the other targeted at the general public for dissemination purposes. The results of the Ecce Homo scientific analysis were exhibited, using a touch-screen interface, and developed for different user levels, from adults to kids.
ACE2 protein expression within isogenic cell lines is heterogeneous and associated with distinct transcriptomes
Authors: Sherman Emily J. , Emmer Brian T. 
Published: August 2021

AbstractThe membrane protein angiotensin-converting enzyme 2 (ACE2) is a physiologic regulator of the renin-angiotensin system and the cellular receptor for the SARS-CoV-2 virus. Prior studies of ACE2 expression have primarily focused on mRNA abundance, with investigation at the protein level limited by uncertain specificity of commercial ACE2 antibodies. Here, we report our development of a sensitive and specific flow cytometry-based assay for cellular ACE2 protein abundance. Application of this approach to multiple cell lines revealed an unexpected degree of cellular heterogeneity, with detectable ACE2 protein in only a subset of cells in each isogenic population. This heterogeneity was mediated at the mRNA level by transcripts predominantly initiated from the ACE2 proximal promoter. ACE2 expression was heritable but not fixed over multiple generations of daughter cells, with gradual drift toward the original heterogeneous background. RNA-seq profiling identified distinct transcriptomes of ACE2-expressing relative cells to non-expressing cells, with enrichment in functionally related genes and transcription factor target sets. Our findings provide a validated approach for the specific detection of ACE2 protein at the surface of single cells, support an epigenetic mechanism of ACE2 gene regulation, and identify specific pathways associated with ACE2 expression in HuH7 cells.
An operator-theoretical study on the BCS-Bogoliubov model of superconductivity near absolute zero temperature
Authors: Watanabe Shuji 
Published: August 2021

AbstractIn the preceding papers the present author gave another proof of the existence and uniqueness of the solution to the BCS-Bogoliubov gap equation for superconductivity from the viewpoint of operator theory, and showed that the solution is partially differentiable with respect to the temperature twice. Thanks to these results, we can indeed partially differentiate the solution and the thermodynamic potential with respect to the temperature twice so as to obtain the entropy and the specific heat at constant volume of a superconductor. In this paper we show the behavior near absolute zero temperature of the thus-obtained entropy, the specific heat, the solution and the critical magnetic field from the viewpoint of operator theory since we did not study it in the preceding papers. Here, the potential in the BCS-Bogoliubov gap equation is an arbitrary, positive continuous function and need not be a constant.
Structural, microstructural, magnetic and electromagnetic absorption properties of spiraled multiwalled carbon nanotubes/barium hexaferrite (MWCNTs/BaFe12O19) hybrid
Authors: Rosdi Nurshahiera , Azis Raba’ah Syahidah , Ismail Ismayadi , Mokhtar Nurhidayaty , Muhammad Zulkimi Muhammad Misbah , Mustaffa Muhammad Syazwan 
Published: August 2021

AbstractMicrowave absorption properties were systematically studied for synthesised barium hexaferrite (BaFe12O19) nanoparticles and spiraled multiwalled carbon nanotubes (MWCNTs) hybrid. BaFe12O19nanoparticles were synthesised by a high energy ball milling (HEBM) followed by sintering at 1400 °C and structural, electromagnetic and microwave characteristics have been scrutinized thoroughly. The sintered powders were then used as a catalyst to synthesise spiraled MWCNTs/BaFe12O19hybrid via the chemical vapour deposition (CVD) process. The materials were then incorporated into epoxy resin to fabricate single-layer composite structures with a thickness of 2 mm. The composite of BaFe12O19nanoparticles showed a minimum reflection loss is − 3.58 dB and no has an absorption bandwidth while the spiraled MWCNTs/BaFe12O19hybrid showed the highest microwave absorption of more than 99.9%, with a minimum reflection loss of − 43.99 dB and an absorption bandwidth of 2.56 GHz. This indicates that spiraled MWCNTs/BaFe12O19hybrid is a potential microwave absorber for microwave applications in X and Ku bands.
Automated tumor proportion score analysis for PD-L1 (22C3) expression in lung squamous cell carcinoma
Authors: Liu Jingxin , Zheng Qiang , Mu Xiao , Zuo Yanfei , Xu Bo , Jin Yan , Wang Yue , Tian Hua , Yang Yongguo , Xue Qianqian , Huang Ziling , Chen Lijun , Gu Bin , Hou Xianxu , Shen Linlin , Guo Yan , Li Yuan 
Published: August 2021

AbstractProgrammed cell death ligend-1 (PD-L1) expression by immunohistochemistry (IHC) assays is a predictive marker of anti-PD-1/PD-L1 therapy response. With the popularity of anti-PD-1/PD-L1 inhibitor drugs, quantitative assessment of PD-L1 expression becomes a new labor for pathologists. Manually counting the PD-L1 positive stained tumor cells is an obviously subjective and time-consuming process. In this paper, we developed a new computer aided Automated Tumor Proportion Scoring System (ATPSS) to determine the comparability of image analysis with pathologist scores. A three-stage process was performed using both image processing and deep learning techniques to mimic the actual diagnostic flow of the pathologists. We conducted a multi-reader multi-case study to evaluate the agreement between pathologists and ATPSS. Fifty-one surgically resected lung squamous cell carcinoma were prepared and stained using the Dako PD-L1 (22C3) assay, and six pathologists with different experience levels were involved in this study. The TPS predicted by the proposed model had high and statistically significant correlation with sub-specialty pathologists’ scores with Mean Absolute Error (MAE) of 8.65 (95% confidence interval (CI): 6.42–10.90) and Pearson Correlation Coefficient (PCC) of 0.9436 ($$p < 0.001$$

p
<
0.001

), and the performance on PD-L1 positive cases achieved by our method surpassed that of non-subspecialty and trainee pathologists. Those experimental results indicate that the proposed automated system can be a powerful tool to improve the PD-L1 TPS assessment of pathologists.
Skeletal muscle is associated with exercise tolerance evaluated by cardiopulmonary exercise testing in Japanese patients with chronic obstructive pulmonary disease
Authors: Tashiro Hiroki , Takahashi Koichiro , Tanaka Masahide , Sadamatsu Hironori , Kurihara Yuki , Tajiri Ryo , Takamori Ayako , Naotsuka Hiroyuki , Imaizumi Hiroki , Kimura Shinya , Sueoka-Aragane Naoko 
Published: August 2021

AbstractDecreasing exercise tolerance is one of the key features related to a poor prognosis in patients with chronic obstructive pulmonary disease (COPD). Cardiopulmonary exercise testing (CPET) is useful for evaluating exercise tolerance. The present study was performed to clarify the correlation between exercise tolerance and clinical parameters, focusing especially on the cross-sectional area (CSA) of skeletal muscle. The present study investigated 69 patients with COPD who underwent CPET. The correlations between oxygen uptake ($${{\dot{\text{V}} \text{O}}}_{2}$$

V
˙

O

2

) at peak exercise and clinical parameters of COPD, including skeletal muscle area measured using single-section axial computed tomography (CT), were evaluated. The COPD assessment test score (ρ = − 0.35, p = 0.02) was weakly correlated with $${{\dot{\text{V}} \text{O}}}_{2}$$

V
˙

O

2

at peak exercise. In addition, forced expiratory volume in one second (FEV1) (ρ = 0.39, p = 0.0009), FEV1/forced vital capacity (ρ = 0.33, p = 0.006), and the CSA of the pectoralis muscles (PMs) (ρ = 0.36, p = 0.007) and erector spinae muscles (ECMs) (ρ = 0.39, p = 0.003) were correlated with $${{\dot{\text{V}} \text{O}}}_{2}$$

V
˙

O

2

at peak exercise. Multivariate analysis adjusted by age and FEV1 indicated that PMCSA was weakly correlated after adjustment (β value [95% confidence interval] 0.175 [0.03–0.319], p = 0.02). In addition, ECMCSA tended to be correlated, but not significantly after adjustment (0.192 [− 0.001–0.385] p = 0.052). The COPD assessment test, FEV1, FEV1/FVC, PMCSA, and ECMCSA were significantly correlated with $${{\dot{\text{V}} \text{O}}}_{2}$$

V
˙

O

2

at peak exercise.
Biological age in healthy elderly predicts aging-related diseases including dementia
Authors: Wu Julia W. , Yaqub Amber , Ma Yuan , Koudstaal Wouter , Hofman Albert , Ikram M. Arfan , Ghanbari Mohsen , Goudsmit Jaap 
Published: August 2021

AbstractApplication of biological age as a measure of an individual´s health status offers new perspectives into extension of both lifespan and healthspan. While algorithms predicting mortality and most aging-related morbidities have been reported, the major shortcoming has been an inability to predict dementia. We present a community-based cohort study of 1930 participants with a mean age of 72 years and a follow-up period of over 7 years, using two variants of a phenotypic blood-based algorithm that either excludes (BioAge1) or includes (BioAge2) neurofilament light chain (NfL) as a neurodegenerative marker. BioAge1 and BioAge2 predict dementia equally well, as well as lifespan and healthspan. Each one-year increase in BioAge1/2 was associated with 11% elevated risk (HR 1.11; 95%CI 1.08–1.14) of mortality and 7% elevated risk (HR 1.07; 95%CI 1.05–1.09) of first morbidities. We additionally tested the association of microRNAs with age and identified 263 microRNAs significantly associated with biological and chronological age alike. Top differentially expressed microRNAs based on biological age had a higher significance level than those based on chronological age, suggesting that biological age captures aspects of aging signals at the epigenetic level. We conclude that accelerated biological age for a given age is a predictor of major age-related morbidity, including dementia, among healthy elderly.
Social engagement and cognitive function among middle-aged and older adults: gender-specific findings from the Korean longitudinal study of aging (2008–2018)
Authors: Oh Sarah Soyeon , Cho Eunhee , Kang Bada 
Published: August 2021

AbstractRecent findings suggest that social disengagement in later life may result in cognitive decline and increase risk of Alzheimer’s and related dementias. However, little is known regarding the gender-specific longitudinal association between social engagement and cognition among middle-aged and older adults. Using data from a nationally representative sample of 2707 men and 5196 women from the Korean longitudinal study of aging, we examined the gender-specific association between social activity and cognitive function. Results from the generalized estimating equation model showed that compared to individuals with consistent social engagement (religious, senior center, sport, reunion, voluntary, political), individuals with inconsistent engagement had lower cognitive function. Transitioning from engagement to non-engagement was associated with lower cognitive function among men only. Not being part of a senior center was associated with decreased cognitive function among both genders, while not being part of a religious group was significant for women only. While marital status was a significant predictor of cognitive ability for women, depression was a significant predictor for men. These findings have implications for policy-makers as interventions targeting improved cognitive function among middle-aged and older adults may be more effective when gender-specific predictors are taken into consideration.
Effectiveness of an ankle–foot orthosis on walking in patients with stroke: a systematic review and meta-analysis
Authors: Choo Yoo Jin , Chang Min Cheol 
Published: August 2021

AbstractWe conducted a meta-analysis to investigate the effectiveness of ankle–foot orthosis (AFO) use in improving gait biomechanical parameters such as walking speed, mobility, and kinematics in patients with stroke with gait disturbance. We searched the MEDLINE (Medical Literature Analysis and Retrieval System Online), CINAHL (Cumulative Index to Nursing and Allied Health Literature), Cochrane, Embase, and Scopus databases and retrieved studies published until June 2021. Experimental and prospective studies were included that evaluated biomechanics or kinematic parameters with or without AFO in patients with stroke. We analyzed gait biomechanical parameters, including walking speed, mobility, balance, and kinematic variables, in studies involving patients with and without AFO use. The criteria of the Cochrane Handbook for Systematic Reviews of Interventions were used to evaluate the methodological quality of the studies, and the level of evidence was evaluated using the Research Pyramid model. Funnel plot analysis and Egger’s test were performed to confirm publication bias. A total of 19 studies including 434 participants that reported on the immediate or short-term effectiveness of AFO use were included in the analysis. Significant improvements in walking speed (standardized mean difference [SMD], 0.50; 95% CI 0.34–0.66; P < 0.00001; I2, 0%), cadence (SMD, 0.42; 95% CI 0.22–0.62; P < 0.0001; I2, 0%), step length (SMD, 0.41; 95% CI 0.18–0.63; P = 0.0003; I2, 2%), stride length (SMD, 0.43; 95% CI 0.15–0.71; P = 0.003; I2, 7%), Timed up-and-go test (SMD, − 0.30; 95% CI − 0.54 to − 0.07; P = 0.01; I2, 0%), functional ambulation category (FAC) score (SMD, 1.61; 95% CI 1.19–2.02; P < 0.00001; I2, 0%), ankle sagittal plane angle at initial contact (SMD, 0.66; 95% CI 0.34–0.98; P < 0.0001; I2, 0%), and knee sagittal plane angle at toe-off (SMD, 0.39; 95% CI 0.04–0.73; P = 0.03; I2, 46%) were observed when the patients wore AFOs. Stride time, body sway, and hip sagittal plane angle at toe-off were not significantly improved (p = 0.74, p = 0.07, p = 0.07, respectively). Among these results, the FAC score showed the most significant improvement, and stride time showed the lowest improvement. AFO improves walking speed, cadence, step length, and stride length, particularly in patients with stroke. AFO is considered beneficial in enhancing gait stability and ambulatory ability.
Effects of soil amendments on leaf anatomical characteristics of marigolds cultivated in cadmium-spiked soils
Authors: Thongchai Alapha , Meeinkuirt Weeradej , Taeprayoon Puntaree , Chelong Isma-ae 
Published: August 2021

AbstractThe marigolds (Tagetesspp.) in this study were classified as excluders for cadmium (Cd); however, their leaves also accumulated substantial Cd content. Among the experimental treatments (i.e., control, cattle manure, pig manure, and leonardite which served as soil amendments), pig manure resulted in significantly increased growth performance for all marigold cultivars as seen by relative growth rates (119–132.3%) and showed positive effects on leaf anatomy modifications, e.g., thickness of spongy and palisade mesophyll, size of vein area and diameter of xylem cells. This may be due to substantially higher essential nutrient content, e.g., total nitrogen (N) and extractable phosphorus (P), in pig manure that aided all marigold cultivars, particularly the French cultivar which exhibited the highest relative growth rate (132.3%). In the Cd-only treatment, cell disorganization was observed in vascular bundles as well as in palisade and spongy mesophyll, which may have been responsible for the lowest plant growth performance recorded in this study, particularly among the American and Honey cultivars (RGR = 73% and 77.3%, respectively).