bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Chinese Medicine Compound in the Treatment of Rheumatoid Arthritis on the Level of Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide Antibodies: A Systematic Review and Meta-Analysis
Authors: Tang Xuan , Liu Zehao , Yang Zhihua , Xu Shengmei , Wang Maojie , Chen Xiumin , Wen Zehuai , Huang Runyue 
Published: June 2021

Objectives: To evaluate the current evidence whether Chinese medicine compound (CMC) can reduce the serum levels of rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibodies (anti-CCP).Methods: We comprehensively searched PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure (CNKI), the Database for Chinese Technical Periodicals (VIP), and Wanfang data. We then performed a systematic review and meta-analysis of all randomized controlled trials (RCTs) assessing the CMC therapy methods. This study is registered with PROSPERO, number CRD42020216284.Results: In total, 65 studies were eligible for inclusion, including 6099 patients. The result of the meta-analysis showed that compared with common Western medicine therapy, CMC monotherapy or combined with Western medicine was able to reduce serum RF (SMD= −0.85, 95%CI −1.04 to −0.67) and anti-CCP (SMD= −0.56, 95%CI −0.79 to −0.32) levels to some extent. In the efficacy meta-analysis, a greater number of CMC-treated patients achieved the efficacy criteria after a period of treatment, where the relative risk (RR) was 1.20 [1.08, 1.33] for achieving ACR20, 1.57 [1.38, 1.78] for ACR50, and 2.21 [1.72, 2.84] for ACR70. At the same time, there was a statistically significant difference in the effective rate of the patient's TCM symptoms (RR = 1.22, 95%CI 1.19–1.26).Conclusions: Through this meta-analysis and systematic review, we found that CMC for the treatment of RA is effective in reducing RF and anti-CCP levels and might have better clinical efficacy than Western medicine monotherapy. Some active components are responsible for this efficacy and worth further exploring.
How to prevent iatrogenic periimplantitis? A clinical case report
Authors: Lomakin М. V. , Labutova А. V. , Soloshansky I. I. 
Published: June 2021

Relevance. Iatrogenic factors are among the significant causes of chronic peri-implantitis, the incidence of which reaches 16-28% according to various data. This article is a clinical case report which describes an approach to the treatment of iatrogenic peri-implantitis associated with a non-absorbable buried suture. Patient Sh., born in 1960, physically healthy, complained of gum bleeding in the region of implant 3.6.Diagnosis. Сhronic peri-implantitis in region 3.6. The treatment was carried out in two stages. During the first (revision) stage, the buried suture of a non-absorbable 2-0 monofilament thread with uncut ends and a loose titanium pin were removed; during the second (reconstructive) stage, a free gingival graft (FGG) was used.Results. The inflammation in the area of implant 3.6 resolved, the soft tissue condition was stable in the immediate and delayed postoperative period. In 3 months after the beginning of the treatment, the cervical bone defect repair was confirmed by the control X-ray.Conclusion. The use of non-absorbable suture material for buried sutures in dental implantation and oral reconstructive surgical interventions is classified as iatrogenesis and is defined as a “medical treatment error”. In the present clinical case, it became the cause of the development of an implant site-specific inflammatory destructive complication. The reduction of chronic peri-implantitis incidence, taking into account its prevalence and problematic nature, requires further research and optimization of the protocols of dental implant treatment.
Surgical treatment of multiple gingival recessions by the combination of autograftand allogenic lyophilized dura mater: a clinical case
Authors: Nosova M. A. , Volova L. T. , Sharov A. N. , Trunin D. A. , Postnikov M. A. 
Published: June 2021

Relevance. Gingival recession is the apical migration of the gingival tissues associated with the exposure of the roots and alveolar bone loss. The prevalence of single recessions in people over 18 years old is 86.7% whereas multiple recessions, i.e. where all teeth are affected, amount up to 28.6%. High prevalence of the pathology necessitates improvement of the approach and tactic of multiple recession treatment in patients with different phenotypes. Nowadays, the use of autograft is the gold standard of multiple recession treatment. However, the technique has its drawbacks. The purpose of the present work was to assess the response to surgery and evaluate the final result of multiple recession treatment in one subject where the combination of autogenic and allogenic grafts was used in the same study design.Materials and methods. The paper presents and describes a clinical case where auto- and allografts were used in one patient to treat multiple gingival recessions.Results. All parameters of the gingival recession assessment showed comparable clinical benefit in all sites of autograft and allograft (dura mater) application. The root coverage was more than 80% around 13 teeth and less than 80% around 11 teeth.Conclusion. The results of the autograft and allograft (dura mater) application were comparable, response to surgery was the same; besides, the allograft (dura mater) is attractive for combined and independent use during surgical treatment of multiple and especially full-mouth recessions.
The effective treatment of tooth sensitivity and adherence: two sides of the same coin
Authors: Iordanishvili A. K. 
Published: June 2021

Relevance. Oral hygiene is of primary importance in the prevention and treatment of tooth sensitivity. Modern oral care products can significantly contribute to the treatment of tooth sensitivity and prevention of its recurrence. Aim – to assess the effectiveness of tooth sensitivity treatment, taking into account the adherence while using a new remineralizing gel manufactured in Russia.Materials and methods. We evaluated the effectiveness of the tooth sensitivity treatment, satisfaction of 45 patients with the treatment and their adherence to the oral care routine. Group 1 used a special toothpaste ASEPTA "PLUS REMINERALIZATION" twice a day. Group 2 also applied a new remineralizing gel ASEPTA for two minutes after brushing.Results. The treatment of tooth sensitivity was effective and ranged between 39.46% and 95.56% during the study. The effectiveness of tooth sensitivity treatment and satisfaction with oral care products were inversely associated with the patient adherence to the medical recommendations. Most patients partially (25% to 50%) adhered to the professional recommendations throughout the study.Conclusion. The tested Russian oral care products effectively prevent tooth sensitivity. During the professional care visit, a dentist or a dental hygienist should pay more attention to increasing patient adherence to the recommendations of a dental professional.
Experimental study of the Ti-implant surfaces structured by the ytterbium-doped pulsed fiber laser
Authors: Yaremenko A. I. , Zernitskaya E. A. , Zotov P. A. , Karlagina Yu. Yu. , Egorova E. E. , Odintsova G. V. 
Published: June 2021

Relevance. Currently, there are several basic techniques for the dental implant surface structuring. Laser treatment is an extremely promising technique for the surface structuring. This technology allows creating regular implant surface without using chemicals and in just one technological step. The purpose was to present study aimed to compare and evaluate in vivo the stability and osseointegration of dental implants with 2 different surfaces structured by ytterbium-doped pulsed fiber laser operating at 1064 nm.Materials and methods. 60 dental implants were placed in the study. 2 types of dental implant surfaces, namely holes and parallel grooves, were created by the ytterbium laser operating at 1064 nm. A polished dental implant (without laser surface structuring) was also included in the experiment for comparison. The study was carried out on 15 laboratory animals (male rabbits, weight 3.5-4 kg). The implants were placed in the tibia. 4 implants with different surface types but of the same diameter and length were placed in each rabbit.Results. Laboratory animals were sacrificed 1.5 and 3 months after the surgery. The stability of the implants was assessed by RFA (Resonance Frequency Analysis), based on the registration of resonance electromagnetic oscillations of the implant and the surrounding bone when they are exposed to the electromagnetic field (Osstell ISQ). Also, nondecalcified bone blocks were histologically examined using a confocal laser scanning microscope (Carl Zeiss LSM 780) and histomorphometry was performed (BIC-index: Bone-to-implant contact). Bone blocks were prepared according to a special technique: they were soaked and embedded into the plastic and synthetic resin. The obtained blocks were cut into sections, 40-50 µm thick, and stained with toluidine blue.Conclusion. Laser surface structuring of the dental titanium implants is a promising technique. 59 in 60 (98.3%) implants were osseointegrated, there were no signs of inflammation in the bone tissue. The present results allow further studying of dental implants with various surface designs, structured by ytterbium laser.
On Possible Macro Consequences of Society Aging: Economic and Statistical Analysis on the Basis of National Transfer Accounts
Authors: Nazarova A. G. 
Published: June 2021

The article discusses research results of socio-economic challenges in modern society using selected international statistics and presented in the format of National Transfer Accounts (NTA) as a follow-up to the author’s prior publications in the journal «Voprosy Statistiki» (Issues 4 and 11 of 2019; Issue 5 of 2020). Introduction to the article rationalizes the subject matter topicality both given the pressing problem of ageing of modern society and in connection with the necessity of practical adoption of National Transfer Accounts in the system of Russian statistics as a coherent derivation and elaboration of the System of National Accounts (SNA), expanding analytical capabilities of statistics. Going into the main part of the article, the author applies statistical methods to explore the key macroeconomic consequences of the global ageing of modern societies. The article provides evidence that macroeconomic challenges and risks to sustainable development emerge primarily in the countries featuring low birth rates, a high share of seniors, and significant levels of government support to the households. The author studies how shifts in the population age distribution translate into changes in consumer spending and incomes. The article presents and analyzes initial findings of the quantitative evaluation of these correlations based on historical data on healthcare expenditures and per capita labor income. The paper identifies the factors and the extent of their impact on how people choose the economic behavior model that ultimately determines the volume and structure of consumption in high inflation economies. Finally, the article lays down a number of conclusions to the following essence: (1) empirical estimates confirm the hypothesis that ageing society presents a heavier «economic burden» for the government finances rather than for the economy as a whole and (2) further advances in macro-statistic work (SNA core sections, National Transfer Accounts, satellite accounts within SNA) become increasingly important for expanding analytical capabilities required to seek for a more effective mechanism to build-up and utilize national resources in the face of population ageing.
Public Spending on Education and Economic Growth: Cross-Country Analysis
Authors: Kolosnitsyna M. G. , Ermolina Yu. E. 
Published: June 2021

This paper aims to identify the relationship between public spending on education and GDP in two groups of countries: members and non-members of the OECD, based on statistical and econometric methods, including the methodology for international comparative analysis. The two selected groups of countries differ in their level of economic development: the OECD, the so-called ‘rich countries club’, and the second group, relatively low-income developing countries. The first part of the article deals with theoretical and information and methodological issues related to research on the relationship between educational development and economic growth, in particular the general theory of human capital investment, human capital in endogenous growth models, principles for empirical estimates of the relationship between education spending and economic growth. In the second part of the article, were tested the hypotheses concerning key factors of economic growth. The authors based them on studied theoretical sources, empirical works, and the proposed statistical base of empirical calculations. The paper substantiated the degree of impact of various factors using different groups of countries as an example. Based on panel data for 1995–2018, we estimate econometric models of the relationship between GDP and education expenditures, using time lags. The results confirm the positive impact of total education spending on GDP in the long term. However, the results differ for the two groups of countries. While in rich countries, investment in all levels of education has a positive impact on GDP, in poor countries, only primary education has a positive return, while spending on secondary and vocational education reduces GDP. This may be due to the lack of demand for high-level education in economies with poorly developed technologies and labor markets. As conclusions, the authors formulate proposals of a managerial and methodological nature regarding the need to consider the country’s development level in its educational policy and choose investment directions that are adequate to the current needs of the economy. In countries with a low level of development and a low level of education for the majority of the population, diverting public resources to finance professional education may slow economic growth in the short term. Conversely, increased coverage of mass primary education may contribute to rapid growth in the near future.
Hemodializ Hastalarında COVID-19'un klinik seyri ve mortalite öngördürücüleri, tek merkez deneyimi
Authors: EVLİCE Oğuz , ÖRS ŞENDOĞAN Damla , AK Öznur 
Published: June 2021

Özet
Giriş
Altta yatan sağlık sorunları ya da komorbiditesi olan COVİD-19 tanılı hastalar, hızlı ve şiddetli progresyon gösterme eğilimindedir. Hemodializ hastalarında üremi nedeniyle baskılanmış immun sistemleri ve eşlik eden hipertansiyon (HT), diyabetes mellitus (DM) ve koroner arter hastalığı (KAH) gibi komorbiditeleri hastalığın ağır seyretmesi için risk oluşturmaktadır. Bu çalışmada COVİD-19 tanısıyla takip edilen hemodializ hastalarının klinik ve laboratuar bulgularını ve prognozu etkileyen risk faktörlerini irdelemeyi amaçladık.
Method
01.08.2020-15.11.2020 tarihleri arasında klinik, laboratuar ve radyolojik bulgularla COVID-19 tanısı konulan 58 erişkin hemodializ hastası retrospektif olarak değerlendirildi.
Bulgular
Çalışmaya dahil edilen 58 hastanın 37'si (% 63.8) erkekti. 54’ünde (%93.1) SARS-CoV-2 PCR testi pozitifti. 4 hastanın (%6,9) PCR testi negatif saptandı, ancak radyolojik ve klinik bulguları COVID-19 pnömonisiyle uyumluydu. En sık görülen semptomlar halsizlik/vücut ağrısı, nefes darlığı ve öksürük, en sık komorbiditeler sırasıyla HT, DM ve koroner arter hastalığıydı. Hastaların 47’si (%81) hayatta kalırken, 11’i (%19) mortalite ile sonlandı. Mortalite ile sonlanan olgular ile sağ kalan olgular karşılaştırıldığında mortalite olan olgularda başvuru esnasında vücut ısısının daha yüksek, oksijen satürasyonunun (p:0,02) , lenfosit sayısının daha düşük olduğu (p:0,03) ve akciğer tomografisinde daha şiddetli tutulum bulguları saptandı. Hastaların tümünde antiviral , destek tedavi yaklaşımı benzer iken mortalite gelişen grupta daha fazla ampirik olarak geniş spektrumlu antibiyotikle birlikte ve kortikosteorid kullanımı saptandı (p
Perbandingan Kinerja Virtual Private Network Antara Vpn Tunnel Dan Internet Protocols Security
Authors: Ariyadi Tamsir , Prabowo Muhamad Agung 
Published: June 2021

Dibutuhkannya komunikasi dalam menunjang interaksi antar perusahaan yang memiliki kaitan yang sangat erat terhadap perkembangan teknologi informasi melalui jaringan komputer. Virtual Private Network atau biasa disebut VPN memiliki peran penting dalam perkembangan sistem keamanan dalam jaringan internet, terutama dalam membatasi hak akses terhadap server, database, dan sejenisnya dalam meminimalisir terjadinya akses illegal terhadap data-data penting perusahaan. VPN memiliki beberapa tipe salah seperti VPN Tunnel dan IPSec, VPN Tunnel memiliki konsep yang lebih sederhana dibandingkan dengan IPSec karena dapat menghubungkan server dan client secara remoteaccess yang hanya membutuhkan 1 router saja yang terhubung pada sisi server. IPSec memiliki tingkat keamanan yang lebih tinggi dibandingkan dengan VPN Tunnel dengan jalur komunikasi dilengkapi dengan kriptografi. IPSec yang berjalan pada L2TP memiliki tingkat kinerja yang lebih baik dibandingkan VPN Tunnel berdasarkan hasil yang telah di dapatkan, karena konsep yang mengharuskan router terkoneksi secara point-to-point. Kata Kunci - Virtual Private Network (VPN), IPSec, Tunneling, Quality of Service, Peformance
Análisis crítico multimodal de grafitis lingüísticos en la comuna de Ñuñoa post 18-O
Authors: Rosillo Villena Juan 
Published: June 2021

Este trabajo analiza nueve grafitis lingüísticos cuyas imágenes fueron fotografiadas en las Avenidas Irarrázaval y Vicuña Mackenna comuna de Ñuñoa, Santiago de Chile, entre diciembre de 2019 y julio de 2020 con el objeto de determinar de qué manera expresan los grafitis seleccionados el discurso opuesto a la dominancia social en el marco del estallido social del 18 de octubre de 2019. Aplicamos un modelo dinámico de tres dimensiones de análisis compuesto por: a) el discurso contrario a la dominancia social, b) el paisaje sociosemiótico urbano de Ñuñoa y, c) el debate sobre el Estado y la Constitución chilena. El análisis considera tres niveles de construcción de significados, a saber: textual, co-textual y contextual, con énfasis en las funciones cognitiva y poética del grafiti, abordados desde el Análisis Crítico del Discurso Multimodal. Los resultados indican que el discurso opuesto a la teoría de la dominancia social analizado se manifiesta por medio de críticas hacia el sistema económico y político imperante, desafío hacia la autoridad y cuestionamiento a la naturalización de la jerarquía social plasmados en el paisaje de una comuna de clase media-alta en el marco de las protestas nucleadas alrededor de diversos movimientos sociales a favor de una reforma constitucional.
Bursa Ataevler Mahallesi'nin LEED ND Kriterleri Kapsamında İncelenmesi
Authors: ÇOBANER Bilgen 
Published: June 2021

Ülkemizde
kentlerin hızlı gelişmesi sonucu yaşanan göçler ve kaliteli yaşam alanları
talebi sonucu köhnemiş ya da rantı
yüksek olan bölgelerde kentsel dönüşüm çalışmaları gözlenmektedir. Bursa kenti yapılaşmanın en fazla olduğu büyük
şehirlerimizdendir. Bursa Ataevler
Mahallesi 1980-90 yıllarında yapılmış olup üst ve üst-orta gelir gruplarına
hitap etmekteydi. Kentin batı ve kuzey
yönlerinde gelişmesi üst gelir gruplarını yeni yerleşim alanlarına
yönlendirdi. Ataevler Mahallesi kent
merkezine ve yeni yerleşim alanlarına toplu taşıma ve otomobillerle olan
ulaşımının kolay olması sebebiyle değerli bir alandır. Bu sebeple kentsel dönüşüm sürecine
girmiştir. Henüz tüm mahalle
dönüştürülmemiştir. Bu sebeple mahallenin kent için katkısı eski ve yeni
halleri ile birlikte incelenmiştir.Kente
bütüncül bir yaklaşım ile yaklaşılması gerekmektedir. Aksi taktirde Ataevler Mahallesi örneği gibi
yeni yerleşim alanı olarak nitelendirebileceğimiz yerler bu şekilde kentsel
dönüşüm uygulamalarına maruz kalmaktadır.
Bu sebeple sürdürülebilir mahalle tasarımları olması gerekmektedir. Ülkemizde mahalleler için bir
sürdürülebilirlik kriteri bulunmamaktadır.
Bu sebeple Amerika'da uygulanan LEED sürdürülebilirlik kriterleri
ülkemizde baz alınan en yaygın sertifika sistemidir. Ataevler Mahallesi de yarı
yeni yarı eski dokusu ile birlikte LEED Neighbourhood Development (LEED ND)
kriterleri kapsamında incelenmiştir.
Kriterler bireysel yapı bazında değil, bütüncül bir mahalle olarak var
olan hali ile incelenmiştir. Araştırmada çalışma alanının incelenmesi, mahalle
ve kentsel sürdürülebilirliğin mahalle ölçeğindeki yeri gibi kavramlar
açıklanmıştır; LEED ND kriterleri incelenmiş ve konuyla ilgili kriterler
açıklanıp ele alınmıştır. Çalışma alanından elde edilen bilgiler LEED ND
kriterlerine göre incelenmiş ve mahallenin var olan durumunun bu
sertifikalandırma sistemine göre sürdürülebilir olup olmadığı sonucuna
varılmıştır.
Kent Ormanlarının Sunduğu Ekolojik Hizmetler
Authors: KALE Bilen 
Published: June 2021

Kent peyzajında - yüzey akışı,
sel riski, partikül kirlenmesi, karbon ayakizi gibi - pekçok çevresel zorluk
daha da güçleşmektedir. Endüstrileşme hareketiyle dramatik bir ivme kazanan
kentleşme, biyoçeşitlilik, biyo-jeo-kimyasal çevrimler, hidroloji, iklim
üzerinde güçlü bir stresördür. Bu bağlamda, kent ağaçları ve kent ormanları , kentsel
su, ısı, toprak ve kirlenme döngüleri üzerine olan pozitif etkileri dolayımında
değerlendirilebilir. Kent ormanları, kentlerdeki yoğun yapılaşmanın yüklenimlerini
ekolojik olarak geri-ödemek ve tekrar kazanmak için önemli olanaklar sunarlar.
Habitat parçalanması telafi edebilirler. Kentsel gri peyzajda yeşil yamalar/koridorlar
yaratabilirler. Kent sakini için rekreatif, düşünsel, zihinsel, ruhsal,
duygusal birçok psiko-sosyal yararlar sağlarlar; sosyal kaynaşmayı geliştirir,
dış mekan aktivitesini teşvik ederler.

Bu makalede, kent ormanlarının
sunduğu çok-yönlü ekolojik hizmetler ele alınarak, kentsel yeşil altyapının
günümüzde hedeflenen direşken-sürdürülebilir kentlerin kurulması yönünde
yapabileceği katkılar değerlendirilecektir.
Kent Parklarının Kullanıcı Memnuniyeti Açısından İrdelenmesi: Çanakkale Örneği
Authors: ALKAN Yavuz 
Published: June 2021

Park
ve bahçeler, daha çok estetik yönü ile kent için, işlevsel yönü ile de toplum
için önemli kentsel yapılardandır. Her iki durumun birlikte ele alınması ve
bütüncül olarak planlamada yer alması önemlidir. Estetik yönü kentlerin kimlik
kazanımında, kullanışlılığı da toplumun yaşam kalitesinde etkilidir. Kullanışlılığın
belirleyicisi park-bahçe donatılarının birey algı ve ihtiyacına göre planlanması memnunluk
oranlarında artışı da beraberinde getirmektedir. Bu amaçla
Çanakkale kentselinde Halk Bahçesi, 500. Yıl Parkı ve Özgürlük Parkı kullanıcılarından
18 yaş üstü 100 kullanıcıyla yüz yüze gelinerek mevcut donatı ve olanaklar ile memnuniyet
oranları arasındaki ilişkinin belirlenmesi amacıyla anket uygulaması
gerçekleştirilmiştir. Elde edilen veriler SPSS 15.0 istatistiki program kapsamında
“doğrusal regresyon analizi” ile değerlendirilmiştir. Buradan bağımlı değişken
(memnunluk oranı) ve bağımsız değişkenler (güvenlik, otopark, bakım, spor,
çocuk oyun ve egzersiz park alanı, kolay ulaşım, gece aydınlatması,
bitkilendirme, donatılar, su kullanımı, mesire-çay bahçesi, wc yapıları,
gezinti yolları, bisiklet yolu, çok amaçlı salon) arasındaki istatistiksel
ilişkilerin tümü, P&lt;0,001 bulunduğundan anlamlı çıkmıştır. "R
square" değerinin 0,332 çıkması,
analizin, modeli % 33 oranında açıklayabildiğini göstermiştir. Ayrıca
memnunluk oranında etkili olan donatı ve olanaklar, etki dercesine göre çoktan
aza doğru, “wc yapısalı, spor alanları,
gezinti yolları, gece aydınlatması, güvenlik, çocuk oyun alanı, donatılar (sınır,
çöp, bank elemanları ve pergola..)” şeklinde sıralanmıştır.