bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multimodal treatments and outcomes for anaplastic thyroid cancer before and after tyrosine kinase inhibitor therapy: a real-world experience
Authors: Park Jun , Jung Hyun Ae , Shim Joon Ho , Park Woong-Yang , Kim Tae Hyuk , Lee Se-Hoon , Kim Sun Wook , Ahn Myung-Ju , Park Keunchil , Chung Jae Hoon 
Published: April 2021

Background
Anaplastic thyroid cancer (ATC) has dismal prognosis and there is no effective treatment. We aimed to evaluate the efficacy of tyrosine kinase inhibitor (TKI) therapy in real-world clinic and to suggest the most effective treatment modality according to the combination of treatments.

Methods
This retrospective study evaluated clinical outcomes and cause of death with multimodal treatments in patients with ATC at Samsung Medical Center.

Results
A total of 120 patients received anti-cancer treatment for ATC. Seventy-seven (64.2%) patients underwent surgery, 64 (53.3%) received radiotherapy, 29 (24.2%) received cytotoxic chemotherapy, and 19 (15.8%) received TKI therapy. In the TKI therapy group, eight achieved partial response (three with lenvatinib and five with dabrafenib plus trametinib), and two patients with lenvatinib showed stable disease. Median progression-free survival (PFS) of the TKI therapy group was 2.7 months (range: 0.1–12.7) and their median overall survival (OS) was 12.4 months (range: 1.7–47.7). Patients who received surgery or radiotherapy for local control showed superior OS than those who did not. In a multivariate analysis, surgery, TKI therapy, younger age, and no distant metastasis were associated with favorable OS. The combination of surgery, radiotherapy, and TKI therapy (median OS: 34.3 months, 6-month survival rates: 77.8%) was the most effective. Compared to the era without TKI therapy, distant metastasis has recently become the major cause of death in ATC over airway problems.

Conclusions
Multimodality treatment including TKI therapy demonstrated prolonged survival with dabrafenib plus trametinib as the most effective therapeutic option demonstrated for BRAF mutant ATC patients.
Assessment of the capabilities of orbital optical devices for obtaining information about space objects
Authors: Prorok Valeriy , Karytko Anatoliy , Goryanskiy Alexander , Emelyanova Ekaterina 
Published: April 2021

The purpose of the study is to select the optimal conditions for collecting non-coordinate information about a spacecraft by a space optical-electronic means at the time objects pass the vicinity of the points of the minimum distance between their orbits. The quantitative indicator is proposed that characterize the measure of the possibility of obtaining non-coordinate information about space objects with the required level of quality. The arguments of the function characterizing the indicator are the distance between spacecraft; their relative speed; phase angle of illumination of a spacecraft by the Sun in relation to the optical-electronic means; the length of the time interval during which both objects are in the vicinity of the point of a minimum distance between their orbits. The value of the indicator is computed by solving three particular research problems.
The first task is to search for neighborhoods that include the minimum distances between the orbits of the controlled spacecraft and optical-electronic means. To solve it, a fast algorithm for calculating the minimum distance between orbits used. Additionally, the drift of the found neighborhoods is taken into account on the time interval up to 60 hours.
The second task is to estimate the characteristics of motion and the conditions of optical visibility of a controlled spacecraft in the vicinity of the minimum points of the distance between the orbits of spacecraft. The solution to this problem is carried out by using the SGP4 library of space objects motion forecast.
The third task is justification and calculation of an index characterizing the measure of the possibility of obtaining an optical image of a spacecraft for given conditions of optical visibility. To solve the problem, the developed system of fuzzy inference rules and the Mamdani algorithm is used.
The presented method is implemented as a program. In the course of a computational experiment, an assessment was made of the possibility of obtaining non-coordinate information on low-orbit and geostationary space objects. The proposed indicator provides an increase in the efficiency of the procedure for collecting non-coordinate information about space objects by choosing the most informative alternatives for monitoring space objects from the available set of possible observations at a given planning interval for collecting information about space objects.
Is seminal pH and liquefaction time effective on motility and morphology?
Authors: DEMİRKOL Mehmet Kutlu , RESİM Sefa , TEMİZ Neslihan , HAMARAT Mustafa Bilal , BARUT Osman 
Published: April 2021

Objective
There are not enough reports about whether liquefaction time and semen pH values are related to sperm functions. Therefore, this study aimed to evaluate whether there is a relationship between pH and liquefaction time and major semen parameters.
Material and Methods
The data were divided into groups as normal and abnormal and compared in terms of pH and liquefaction times. The samples were also grouped according to semen pH as acidic (8.0) and liquefaction time as normal liquefying (≤30 min.) and slow liquefying (> 30 min.), and then were compared in terms of the normal/abnormal status of concentration, motility and morphology.
Results
Of the 600 semen samples, 400 (66.7%) were grouped as abnormal and 200 (33.3%) as normal. The median pH and liquefaction time of the abnormal group were statistically higher than the normal group (both, p
INFORMAL INDUSTRIES IN INDIA: PRESENT SCENARIO, GAP AND OPPORTUNITIES BY
Authors: Sankar Jyoti Nath, Dr. Biju Mani Das Krishna Kumar Thakur, 
Published: April 2021

India is one of the biggest markets in the world; here mainly two types of industry are in scenario either formal or informal. Whereas informal sector is widespread across the geography and it contributes to the economy of country. Most of the employment comes from this sector; still it is the most neglected sector in India. It is also the most exploited industry in India.
This study aims at gaining an in depth overview of the informal sector in Indian context.
ANALYTICAL INVESTIGATIONS OF MECHANICAL PROPERTIES OF SEMI SOLID PROCESSED ALUMINIUM 7075 ALLOY
Authors: Dr. S. Rajesham, Dr. M. Manzoor Hussain S.Venkata Narasimha Rao, 
Published: April 2021

At present for industries it is a challenge to produce products of good quality and should have high durability. In this engineering world there is great a great need of various engineering materials to satisfy these engineering needs. The material usage mainly depends on the material strength and properties. Aluminum-7075 alloy is primarily used for transport applications, such as aerospace, maritime and automotive industries, thanks to its good mechanical properties and a low density. For the semi-solid formation of aluminium alloys, a homogenous equiased grain structure is required. The stress mediated melting mechanism is one of the approaches used to achieve such a microstructure.
The present work describes the synthesis of Al 7075 semi solid metal matrix composite reinforced with graphene and the characterization of their mechanical properties. Graphene is added to aluminium-7075 and samples are prepared both with stirring and without stirring at varying temperatures. The samples are prepared at 6800c, 7100c, 7400c, 7700c, 8000c, 8300c, 8600c, 8900c, 9200c.
At these temperature the material is mostly semi-solid Aluminium 7075 and graphene is added to this semi-solid molten melt and stirred with stirrer. The specimens are prepared according to ASTM standards. The tests like hardness, tensile, impact and compression tests are performed and the values are compared. The tensile power, hardness, compression reduces as its temperature increases. The specimens are analysed using ANSYS software. The specimens with stirring has good mechanical properties than without stirring. Graphene has good mechanical characteristics such as strength and hardness.
SUPPLY CHAIN MANAGEMENT AND ITS PRACTICAL IMPACT
Authors: Et. al. Shreyansh Jain, 
Published: April 2021

This paper studied about the role of different independent factors on supply chain responsiveness. Here, we considered factors such as joint decision making, information quality and performance risk as three independent variables and supply chain responsiveness as a dependent variable. We tried to survey different supply chain professionals working in different sectors to have an unbiased image in our study.
After applying Pearson corelation in our study, we understood the significance of our independent variables on supply chain responsiveness. The positive significance shows the importance of these factors while working on our dependent variable. All three relationships are showcasing either positive or strong corelation. Finally, we could infer that there are a lot more factors that we can take in to consideration for calculating the impact on supply chain responsiveness in future studies. This will definitely strengthen the case and will help in practical explanation.
AWARENESS ON PENSION PLANS-A STUDY OF INVESTORS’ IN BENGALURU CITY
Authors: B.V. Pushpa 
Published: April 2021

Individuals make inconsistent, irrational financial decisions mainly due to disproportionate time preferences. Bias and procrastination prevail. Along with a default option, there is a need for a customized plan with individuals' socio-cultural and economic status. Low participation rates are mainly due to a lack of awareness of pension literacy and behavioral aspects. Individuals have failed to create a corpus to protect themselves for retirement as there is a lack of awareness to suitability of a plan to one’s situation, failure to measure income adequacy at retirement, not able to identify the link between contributions made and pension drawdown, etc. Age and gender differences prevail strongly. Defined contribution plans are likely to dominate in global pension model in the years to come. Individuals are ready to own their risk but have little control and knowledge to cover themselves. Frequent timely and prompt advice or counseling from investment advisors will enable participants to understand the need, identify suitable options and schemes, and provide themselves with sustainable long-term savings. This should convert willingness to participate to real participation.
Keywords: Financial literacy, Pension knowledge, Defined contribution pension plans (DCP), irrational decision making, demographics.
PERFORMANCE COMPARISON OF UNSUPERVISED SEGMENTATION ALGORITHMS ON RICE, GROUNDNUT, AND APPLE PLANT LEAF IMAGES
Authors: Et. al. Rajendra Prasad Bellapu, 
Published: April 2021

This paper focuses on plant leaf image segmentation by considering the aspects of various unsupervised segmentation techniques for automatic plant leaf disease detection. The segmented plant leaves are crucial in the process of automatic disease detection, quantification, and classification of plant diseases. Accurate and efficient assessment of plant diseases is required to avoid economic, social, and ecological losses. This may not be easy to achieve in practice due to multiple factors. It is challenging to segment out the affected area from the images of complex background. Thus, a robust semantic segmentation for automatic recognition and analysis of plant leaf disease detection is extremely demanded in the area of precision agriculture. This breakthrough is expected to lead towards the demand for an accurate and reliable technique for plant leaf segmentation. We propose a hybrid variant that incorporates Graph Cut (GC) and Multi-Level Otsu (MOTSU) in this paper. We compare the segmentation performance implemented on rice, groundnut, and apple plant leaf images for various unsupervised segmentation algorithms. Boundary Displacement error (BDe), Global Consistency error (GCe), Variation of Information (VoI), and Probability Rand index (PRi), are the index metrics used to evaluate the performance of the proposed model. By comparing the outcomes of the simulation, it demonstrates that our proposed technique, Graph Cut based Multi-level Otsu (GCMO), provides better segmentation results as compared to other existing unsupervised algorithms.
EMBRYOTOXICITY AND TERATOGENIC EFFECTS OF PARMOTREMA TINCTORUM (NYL) HALE ON ZEBRAFISH (DANIO RERIO) AND CYTOTOXIC ACTIVITY OF LICHEN EXTRACT ON HEK293T CELL LINE
Authors: Et. al. M. Shenbagam, 
Published: April 2021

Parmotrema tinctorum (Nyl) Hale an edible lichen, used as a spice and flavouring agent for meat and vegetable preparations by ethnic groups in India and Nepal. In Zebrafish embryos and larva, the therapeutic applications of P.tinctorum widely reported. However the teratogenic effects not reported. This study was aimed to examine the toxicity of P.tinctorum on the promising model for toxicity research, the Zebrafish, because their genetic structure is more similar to human beings. Additionally, we have demonstrated a toxic effect of P.tinctorum extract on the human normal cell line (HEK293T) by MTT assay. The methanol extract of P.tinctorum was extracted by Soxhlet and for embryotoxicity and teratogenicity activities, we use different concentrations (50µg/ml – 200µg/ml) of lichen extracts on twelve selected fertilized Zebrafish embryos. The extract did not exhibit any effect on Zebrafish Survival rate, hatching rate, heartbeat and teratogenicity which was similar to control groups. To conclude that, methanol extract of P.tinctorum is found to have a nontoxic property to zebrafish embryo and human normal cell line (HEK293T) and suggests that this might be safe for consumption
9T SRAM CELL WITH MT-SVL TECHNIQUE FOR LEAKAGE POWER REDUCTION
Authors: Et. al. Kothamasu Jyothi, 
Published: April 2021

With the technology scaling there is a decrease in transistor size and increase in number of the transistors per a chip. It causes tremendous increase in complexity and the power dissipation of circuits. This paper mainly focuses on reduction of leakage power dissipation in SRAM 9T cells by employing multi threshold self controllable voltage level circuits (LSVL & USVL). The Simulation results show that with the employment of MT-SVL technique, leakage power is being reduced compared to the improved SVL technique. The overall simulation is done with CMOS 180nm technology, using the tool of Cadence Virtuoso.
ANALYZING THE OPERATIONAL AND LOGISTICS REQUIREMENTS BY EVALUATING THE MARKET POTENTIAL FOR E-LOGISTIC SUPPORT PROVIDER
Authors: Ramkrishna Manatkar Nikhil Satpute, 
Published: April 2021

continuously 2020. The Indian government has made a declaration that it is working at the approach to build up the new logistics plan in India. The point is to build up the most prudent approach to transport products by 2035.
As we know logistics is a highly diverse gambit consisting many factors and variables, we decided to focus on Trucking segment of logistics in Mumbai region. Mumbai is a city in Maharashtra, India. To know more about the market and its potential we needed to know more about the transporters and manufacturing industries in Mumbai. As transporters in Mumbai can get us about the idea of logistical truck movements inside and outside Mumbai, and the manufacturing industries can suggest us about which type of trucks are required by them according to the raw materials they need or the final products they distribute. Apart from the logistic movement in and out of Mumbai, we also tried to capture the openness of transporter to sign up for e-logistic service provider and try to expand their business by adding a technological aspect to it.
Research contains detailed and verified information of 57 transporters and on all possible combination of types of trucks provided by transporter and their operational routes. Also, we have recognized total of 125 Manufacturing companies from various industries, having one or more plant in or around Mumbai. Also, we classified the 125 companies into 15 Industries These companies have some raw material movements into Mumbai and some finish goods movement from Mumbai to various parts of India.
By analyzing the collected data, we found out which type of truck have how much demand on which route. Also, we could figure out the willingness of transporter to work in collaboration with e-logistics company
AUGMENTED REALITY AND VIRTUAL REALITY IN RETAIL - A BIBLIOMETRIC ANALYSIS
Authors: Bardhan Anasuya 
Published: April 2021

Purpose – “Augmented and Virtual Reality” is a trend in retail that is lately catching a lot of attraction. These interactive technologies enhance the retail process by offering a better shopping experience and affects consumer's preference towards the retailers. Retailers need to align their business model to counteract the changing traffic patterns. This study will help in inferring trends, themes researched, identifying the prolific authors, researchers, and present the big picture.
Methodology - To understand the current research state, Biblioshiny and VOS viewer has been employed to conduct a quantitative study on research papers done in the field of AR/VR in retail during the period 1993-2020 from the “Web of Science core database”.

Findings - (1) Increase in publication of papers in the past 27 years, divided into 2 parts: a low exploration period and developmental period. (2) The research covers 38 countries. With respect to the research volume, the top five countries being – (i) “China”, (ii) “the United States”, (iii) “the United Kingdom”, (iv) “Germany”, and (v) “South Korea”. There has been a lot of collaboration between these countries, with maximum collaboration between the USA and China. (3) Virtual Reality, Retailing, Interactivity are amongst the trending keywords in this field in recent years. (4) The main research themes in area of AR/VR in retail mainly focuses on the research directions like – the adoption of the technology, impact on consumer behavior, and performance and user's information control.

An overview of present state of academic studies was generated by employing a knowledge-based map which recognises researcher collaboration networks. This study is riveting as it has rarely been examined in this in a new manner.
A STUDY ON THE USE OF ICT IN PRE SERVICE TEACHER EDUCATION IN DELHI
Authors: Teotia Dr. Anil Kumar 
Published: April 2021

In using technology in the classrooms, the efficiency of the teachers is directly proportional to the outcomes it follows. In the present study, the researcher tried to study the impact of ICT on the achievement level (in Mathematics Education) of elementary teacher trainees in Delhi and their opinions about using ICT in the classroom. The elementary teacher trainees of Delhi were the sample population for the current study. The opinions from various teacher educators, parents and teacher trainees were collected. The qualitative and quantitative data collected from different stakeholders were analysed and synthesised. It was found that the learning of all trainees was improved through the use of ICT in the classroom. However, the high achievers were more benefited than the low achievers.
Moreover, trainees think that the use of technology in their classrooms has a positive impact on their academic scores, and they find learning easy with the use of technology. Trainees did not accept the positive role of technology in the learning of co-curricular subjects. Further, trainees with better technological infrastructure availablein institutes performed better on achievement tests. Despite having better technological infrastructure, trainees do not like the idea of total dependency on ICT with the 'no teacher in class’ method. They preferred and voted for the active role of educators in the classrooms.However, parents (mainly mother) consider that ICT has a positive impact on trainees’ learning. The interviews with teacher educators concluded that the trainees' basic writing, reading, calculating etc., were improved significantly by using ICT. However, they refused to accept any pedagogical advantage of using computers/overhead projectors in the teacher training programme.
ROLE OF “HUMAN LIBRARY INTERVENTION” IN CREATING AWARENESS OF DIVERSITY & INCLUSION
Authors: Et. al. Dr. Kasturi R Naik 
Published: April 2021

The advent of globalization, workforce mobility, and international projects are generating demands for culturally proficient individuals and post pandemic there is scope of creating awareness of diversity & inclusion across globe using technology. Education, training, and development of these employees begin in the webroom now (Van Dyne, Ang, Livermore, 2010).
Diversity and inclusion efforts tussle since they often attempt to find a one-size-fits-all solution to eradicating bias. The Human Library is making an influence, because their approach is personalized to each individual’s own biases and prejudices. They’re tackling diversity and inclusion one person at a time and now with advent of technology they can do it on a large scale and see the benefits.
The main drive of this paper is to examine whether the education system plays an important role in developing an individual with an open outlook without any discrimination, stereotypes, and prejudice and the important use of the human library as a tool to develop this open outlook. The research objectives of this paper include focusing on the theoretical and practical concepts of emotional intelligence, stereotypes, discrimination, prejudice and establishing a relationship between these concepts and the human library utilizing thorough literature review and consolidation.
Pengaruh Pemberian Antibiotik terhadap Tanda Infeksi Daerah Operasi Superfisial dan Lama Tinggal Pasien Sectio Caesaria
Authors: Sumiartini Teulis , Laksmitawati Dian Ratih , Ramadaniati Hesti Utami , Natadidjaja Ronald Irwanto , Asmajaya Rudi 
Published: April 2021

LATAR BELAKANG
Standar Nasional Akreditasi Rumah Sakit (SNARS) edisi 1 / 2018 menjadikan kejadian Infeksi Daerah Operasi (IDO) sebagai salah satu indikator mutu untuk menilai kinerja pengendalian infeksi di rumah sakit. Pemberian antibiotik lanjutan paska operasi sectio caesaria (SC) menjadi isu yang penting untuk dikaji, mengingat operasi ini pada dasarnya tidak membutuhkan pemberian antibiotik lanjut paska operasinya. Pemberian antibiotik lanjutan paska operasi SC merupakan penggunaan antibiotik tidak bijak.

METODE
Pasien dibagi menjadi 2 kelompok dengan jumlah masing-masing sebesar 49 subjek. Kelompok pertama adalah kelompok subjek yang diberikan antibiotik lanjut paska SC dan kelompok kedua adalah kelompok subjek dengan pemberian antibiotik tidak lanjut paska SC kemudian dari masing-masing kelompok dikaji kemungkinan munculnya tanda IDO dan LOS pasien. Desain penelitian ini adalah kohort retrospektif dengan data sekunder dari rekam medis pasien Januari 2019 - Desember 2019. Uji analisa dengan chi square. Data dianalisa dengan SPSS Statistics.

HASIL
Setelah mengontrol variabel perancu, pemberian antibiotik lanjut paska SC tidak signifikan berpengaruh menurunkan kemungkinan munculnya tanda IDO (OR = 0.157; p=0.098; 0.02-1.41 IK95%), juga tidak memiliki pengaruh terhadap LOS pasien (OR=1.73; p=0.562; 0.27-10.85 IK 95%).

KESIMPULAN
Tidak terdapat pengaruh dari pemberian antibiotika lanjutan terhadap tanda kejadian IDO dan LOS pada pasien post SC sebelum dan setelah mengontrol variabel perancu. Pemberian antibiotik lanjutan paska SC merupakan pemberian antibiotik yang tidak bijak.