bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intensive multidisciplinary feeding intervention for patients with avoidant/restrictive food intake disorder associated with severe food selectivity: An electronic health record review
Authors: Volkert Valerie M. , Burrell Lindsey , Berry Rashelle C. , Waddle Caitlin , White Lydia , Bottini Summer , Murphy Meredith , Sharp William G. 
Published: September 2021

AbstractObjectiveExpert consensus increasingly recognizes intensive multidisciplinary intervention (IMI) as the standard of care to address chronic and severe feeding problems in pediatric populations. In this study, we examined the clinical presentation, intervention characteristics, and treatment outcomes for young children receiving IMI for avoidant restrictive rood intake disorder (ARFID) involving nutritional insufficiencies associated with severe food selectivity.MethodWe followed the Strengthening the Reporting of Observational Studies in Epidemiology statement to conduct this retrospective chart review. The review focused on consecutive patients (birth to age 21 years) admitted to the IMI program over a 5‐year period (June 2014 to June 2019). Inclusion criteria required micronutrient insufficiencies (vitamins A, B12, C, D, E; folic acid; calcium; iron; and zinc) and chronic mealtime refusal behavior (e.g., turning head away from food/spoon, pushing or throwing spoon, crying, screaming, and leaving the table) associated with severe food selectivity.ResultsOver the 5‐year period, 63 of the patients met study entry requirements. Of these, 60 patients (50 boys and 10 girls; mean age = 72 ± 39 months; range = 23–181) completed intervention (95% treatment completion rate). At discharge, dietary diversity improved by 16 new therapeutic foods (range: 8–22), rapid acceptance and swallowing of new foods exceeded clinical benchmarks (80% or > bites), and risk for nutritional inadequacies declined for this patient cohort.DiscussionResults of the current study support the benefits of IMI to increase dietary variety, improve mealtime behaviors, and enhance nutritional intake for children with ARFID presenting with severe food selectivity.
Importance of a turbulent river section below a giant waterfall for fish spawning: Indications from drift and dispersion patterns of early life stages
Authors: Makrakis Maristela C. , Refatti Alcione , Keckeis Hubert , da Silva Patrícia S. , de Assumpção Lucileine , Kashiwaqui Elaine A. L. , Gamaro Paulo E. , Makrakis Sergio 
Published: September 2021

AbstractSeasonal drift patterns of fish eggs and larvae were analysed along the river section downstream the Iguaçu River Falls to the confluence with Paraná River, over three spawning seasons. This river section is situated in a narrow rocky canyon characterized by a steep slope, which leads to highly turbulent and fast flowing conditions in a series of rapids. Water transit time in this river stretch of 20 km was short (5–11 h), the flow‐velocity in rapids can reach values of more than 6 m s−1. Densities of drifting eggs and larvae varied between three spawning seasons, and differences of eggs were more pronounced compared to larvae. Eggs and larvae were observed all along the river section. A spatial, longitudinal distribution pattern of larvae was found, with higher numbers in the upper section. A distinct spatial sequence of different embryonic stages was observed, with the highest abundance of early stages. Larval densities were low in comparison to egg densities, and preflexion and flexion stages predominated. High abundance of buoyant eggs in drift indicates fish spawning in rapid and turbulent waters of the Iguaçu River, particularly downstream from the Iguaçu Falls. Rainfall and turbidity may be the main trigger for spawning. Spawned eggs drifted quickly towards the confluence, most are likely to hatch in the Paraná River, while larvae disperse to nursery habitats even in the river section below the falls. Thus, inshore zones along the whole stretch provide nursery habitats for larval development of fish species exhibiting different reproductive strategies.
Using single visits into integrated occupancy models to make the most of existing monitoring programs
Authors: Lauret Valentin , Labach Hélène , Authier Matthieu , Gimenez Olivier 
Published: September 2021

AbstractA major challenge in statistical ecology consists of integrating knowledge from different data sets to produce robust ecological indicators. To estimate species distribution, occupancy models are a flexible framework that can accommodate several data sets obtained from different sampling methods. However, repeating visits at sampling sites is a prerequisite for using standard occupancy models. Occupancy models were recently developed to analyze detection/non‐detection data collected during a single visit. To date, single‐visit occupancy models have never been used to integrate several different data sets. Here, we showcase an approach that combines two data sets into an integrated single‐visit occupancy model. As a case study, we estimated the distribution of common bottlenose dolphin (Tursiops truncatus) over the northwestern Mediterranean Sea by combining 24,624 km of aerial surveys and 21,464 km of at‐sea monitoring. We compared the outputs of single‐ vs. repeated‐visit occupancy models into integrated occupancy models. Integrated models allowed a better sampling coverage of the targeted population, which provided a better precision for occupancy estimates than occupancy models using data sets in isolation. Overall, single‐ and repeated‐visit integrated occupancy models produced similar inference about the distribution of bottlenose dolphins. We suggest that single‐visit occupancy models open promising perspectives for the use of existing ecological data sets.
Systematic analysis of CD39, CD103, CD137, and PD‐1 as biomarkers for naturally occurring tumor antigen‐specific TILs
Authors: Eiva Monika A. , Omran Dalia K. , Chacon Jessica A. , Powell Daniel J. 
Published: September 2021

AbstractThe detection of tumor‐specific T cells in solid tumors is integral to interrogate endogenous antitumor responses and to advance downstream therapeutic applications. Multiple biomarkers are reported to identify endogenous tumor‐specific tumor‐infiltrating lymphocytes (TILs), namely CD137, PD‐1, CD103, and CD39; however, a direct comparison of these molecules has yet to be performed. We evaluated these biomarkers in primary human ovarian tumor samples using single‐cell mass cytometry to compare their relative phenotypic profiles, and examined their response to autologous tumor cells ex vivo. PD‐1+, CD103+, and CD39+ TILs all contain a CD137+ cell subset, while CD137+ TILs highly co‐express the aforementioned markers. CD137+ TILs exhibit the highest expression of cytotoxic effector molecules compared to PD‐1+, CD103+, or CD39+ TILs. Removal of CD137+ cells from PD‐1+, CD103+, or CD39+ TILs diminish their IFN‐γ secretion in response to autologous tumor cell stimulation, while CD137+ TILs maintain high HLA‐dependent IFN‐γ secretion. CD137+ TILs exhibited an exhausted phenotype but with CD28 co‐expression, suggesting possible receptiveness to reinvigoration via immune checkpoint blockade. Together, our findings demonstrate that the antitumor abilities of PD‐1+, CD103+, and CD39+ TILs are mainly derived from a subset of CD137‐expressing TILs, implicating CD137 as a more selective biomarker for naturally occurring tumor‐specific TILs.
Polar Lanthanide Anthracene Complexes Exhibiting Magnetic, Luminescent and Dielectric Properties
Authors: Sun Guo‐Bin , Huang Xin‐Da , Shang Tao , Yan Shuo , Bao Song‐Song , Lu Xiao‐Mei , Zhang Yi‐Quan , Zheng Li‐Min 
Published: September 2021

AbstractMultifunctional molecular materials combining magnetic, luminescent and dielectric properties are attractive for potential applications in spintronics and molecular devices. Herein we report three isostructural mononuclear lanthanide phosphonates, namely, Ln(NO3)3(2‐deap)3 [Ln=Dy (1Dy), Er (2Er), Yb (3Yb), 2‐deap=diethyl anthrancen‐2‐ylphosphonate] which crystallize in polar space group Pna21. Magnetic studies revealed field‐induced slow magnetization relaxation for 1Dy and 3Yb, but not for 2Er down to 1.8 K. Theoretical calculations were conducted to rationalize the magneto‐structural relationship. The photoluminescent properties are also dependent on the lanthanide ion. For 1Dy, luminescence was observed only in the visible region mainly originating from the ligand. For 2Er, luminescence was observed only in the near‐infrared (NIR) region due to a complete energy transfer from the ligand to the ErIII ion. Regarding to 3Yb, luminescence was observed in both visible and NIR regions suggesting a partial energy transfer from the ligand to YbIII ion. Dielectric and piezoelectric measurements were performed on single crystals of 3Yb, which confirmed the presence of high dielectric anisotropy and weak piezoelectric response.
Seismic reliability implied by behavior‐factor‐based design
Authors: Baltzopoulos Georgios , Grella Antonio , Iervolino Iunio 
Published: September 2021

AbstractForce‐based seismic design involves the reduction of elastic spectra by introducing a behavior factor, q. This approach is widespread in engineering practice; however, recent studies have shown that structures consistently designed at different sites will not share the same level of seismic risk, which can be defined as the annual rate of the structure failing to meet a seismic performance objective, despite seismic actions having the same exceedance return period at all sites. This paper investigates whether the definition of site‐specific q factors can lead to uniform risk across sites characterized by varying levels of seismic hazard, based on the pushover curves of bare frame reinforced concrete buildings. These pushover curves are used to establish the backbones of equivalent single degree of freedom systems with varying lateral resistance. These systems are fictitiously placed at several Italian sites and their seismic failure risk is computed by integrating their fragility, assessed by means of incremental dynamic analysis, with each site's hazard curve. By assuming an arbitrary risk threshold, the same for all sites, the corresponding lateral strength leading to said threshold is determined and the corresponding behavior factor is back calculated. As expected, risk‐targeted q factors tend to increase with decreasing seismic hazard and are highly sensitive to the shape of the hazard curve beyond the design return period. Coupled with the fact that at low hazard sites lateral strength is determined by detailing for gravity‐load design and minimum code requirements, rather than seismic design actions, the results suggest that q factor‐based design is unsuitable for warranting territorially uniform seismic safety, yet it may be suitable for setting an upper‐bound to the annual failure probability.
A Multi–Life Stage Comparison of Silver Nanoparticle Toxicity on the Early Development of Three Canadian Fish Species
Authors: Schultz Dayna R. , Tang Song , Miller Christie , Gagnon Danielle , Shekh Kamran , Alcaraz Alper J. G. , Janz David M. , Hecker Markus 
Published: September 2021

Abstract
Information on the effects of silver nanoparticles (AgNPs) in fish has mostly been generated from standard laboratory species and short-term toxicity tests. However, there is significant uncertainty regarding AgNP toxicity to native species of concern in North America, particularly in northern freshwater ecosystems. We assessed the chronic toxicity of AgNPs in early life stages of three North American fish species: rainbow trout (Oncorhynchus mykiss), lake trout (Salvelinus namaycush), and northern pike (Esox lucius). Newly fertilized embryos were exposed to nominal aqueous concentrations of 0.1, 0.3, 1.0, 3.0, 10.0, or 30.0 nM AgNPs for 126 (rainbow trout), 210 (lake trout), and 25 (northern pike) days. Endpoints included cumulative developmental time (°C × day or degree-days to 50% life-stage transition), mortality, fork length, embryonic malformations, cumulative survival, and histopathology of gill and liver in larvae/alevins. The results showed life stage–specific differences in responses, with endpoints during the embryonic stage occurring more often and at lower concentrations compared to larval/alevin and juvenile stages. Sensitivities among species were highly dependent on the endpoints measured, although developmental time appeared to be the most consistent endpoint across species. At embryonic and larval/alevin stages, northern pike was the most sensitive species (lowest observable effect concentration of 0.1 nM using developmental time). Rainbow trout displayed similar responses to lake trout across multiple endpoints and therefore seems to be an adequate surrogate for trout species in ecotoxicology studies. Moreover, while mortality during individual life stages was not generally affected, the cumulative mortality across life stages was significantly affected, which highlights the importance of chronic, multi-life-stage studies. Environ Toxicol Chem 2021;40:3337–3350. © 2021 SETAC
Role of stilbenes against insulin resistance: A review
Authors: Shazmeen  , Haq Iahtisham‐Ul , Rajoka Muhammad Shahid Riaz , Asim Shabbir Muhmmad , Umair Muhammad , llah Inam‐u , Manzoor Muhammad Faisal , Nemat Arash , Abid Muhammad , Khan Moazzam Rafiq , Aadil Rana Muhammad 
Published: September 2021

AbstractInsulin resistance (IR) is a state characterized by the inability of tissues to utilize blood glucose particularly liver, muscle, and adipose tissues resulting in hyperglycemia and hyperinsulinemia. A close relationship exists between IR and the development of type 2 diabetes (T2D). Therefore, therapeutic approaches to treat IR also improve T2D simultaneously. Scientific evidence has highlighted the major role of inflammatory cytokines, reactive oxygen species (ROS), environmental & genetic factors, and auto‐immune disorders in the pathophysiology of IR. Among therapeutic remedies, nutraceuticals like polyphenols are being used widely to ameliorate IR due to their safer nature compared to pharmaceutics. Stilbenes are considered important metabolically active polyphenols currently under the limelight of research to cope with IR. In this review, efforts are made to elucidate cellular and subcellular mechanisms influenced by stilbenes including modulating insulin signaling cascade, correcting glucose transport pathways, lowering postprandial glucose levels, and protecting β‐cell damage and its effects on the hyperactive immune system and proinflammatory cytokines to attenuate IR. Furthermore, future directions to further the research in stilbenes as a strong candidate against IR are included so that concrete recommendation for their use in humans is made.
Effect of protein and carbohydrate distribution among meals on quality of life, sleep quality, inflammation, and oxidative stress in patients with type 2 diabetes: A single‐blinded randomized controlled trial
Authors: Nouripour Fatemeh , Mazloom Zohreh , Fararouei Mohammad , Zamani Ali 
Published: September 2021

AbstractBackground/ObjectivesPatients with diabetes mellitus have a lower quality of life and sleep compared with healthy individuals. Nutrition therapy has an important role in the management of diabetes and can improve inflammation and quality of life in patients with diabetes. The present study aimed to evaluate the effect of high‐protein versus high‐carbohydrate intake during evening meal on quality of life, sleep quality, inflammation, and oxidative stress in subjects with type 2 diabetes.Subjects/MethodsThis is a 10‐week randomized controlled trial. 96 adult patients with type 2 diabetes were assigned into one of the following three groups: standard evening meal (ST), high‐carbohydrate evening meal (HC), and high‐protein evening meal (HP). The effect of these diets was examined on high‐sensitivity C‐reactive protein, malondialdehyde, quality of life, and sleep quality.ResultsSleep quality improved significantly in all groups (p < .05). The quality of life and high‐sensitivity C‐reactive protein improved in all groups except for the HP group (p < .05). Serum malondialdehyde level did not change significantly throughout the study (p > .05).ConclusionsSmall manipulation of protein and carbohydrate distribution among the meals might not affect sleep quality. A diet with an even distribution of macronutrients among the meals or with a higher percentage of carbohydrates in the evenings can improve the quality of life and reduce inflammation in patients with type 2 diabetes, while a diet with a higher percentage of protein in the evenings may not improve it.
On the incorporation of a micromechanical material model into the inherent strain method—Application to the modeling of selective laser melting
Authors: Noll Isabelle , Bartel Thorsten , Menzel Andreas 
Published: September 2021

AbstractWhen developing reliable and useful models for selective laser melting processes of large parts, various simplifications are necessary to achieve computationally efficient simulations. Due to the complex processes taking place during the manufacturing of such parts, especially the material and heat source models influence the simulation results. If accurate predictions of residual stresses and deformation are desired, both complete temperature history and mechanical behavior have to be included in a thermomechanical model. In this article, we combine a multiscale approach using the inherent strain method with a newly developed phase transformation model. With the help of this model, which is based on energy densities and energy minimization, the three states of the material, namely, powder, molten, and resolidified material, are explicitly incorporated into the thermomechanically fully coupled finite‐element‐based process model of the micromechanically motivated laser heat source model and the simplified layer hatch model.
Frequency of contact with friends and relatives via internet and psychosocial factors in middle‐aged and older adults during the COVID‐19 pandemic. Findings from the German Ageing Survey
Authors: Hajek André , König Hans‐Helmut 
Published: September 2021

AbstractObjectivesPrevious studies have examined the association between frequency of contact with friends and relatives via internet and psychosocial factors (in terms of loneliness, life satisfaction and depressive symptoms). However, far less is known about such a link during the COVID‐19 pandemic, particularly based on nationally representative samples. Therefore, the aim of this study was to examine this association among middle‐aged/older adults.Methods/DesignData were taken from the short survey of the German Ageing Survey (June/July 2020, 3134 individuals in the analytical sample). The De Jong Gierveld scale was used to quantify loneliness, the Satisfaction with Life Scale was used to quantify life satisfaction and the 10‐item version of the Center for Epidemiological Studies‐Depression was used to quantify depressive symptoms.ResultsRegressions showed that—compared to daily users—less frequent users of the internet for contact with friends and relatives reported increased loneliness, lower life satisfaction and more depressive symptoms. With regard to covariates, better psychosocial factors were associated with medium education (compared to low education), living with partner in the same household (compared to singles), better self‐rated health, and favourable COVID‐19 factors (in terms of decreased feeling that the Corona crisis is a threat for oneself, not having an infection with the coronavirus and an increased feeling that you can influence an infection with the coronavirus yourself).ConclusionsData suggest that individuals with a high frequency of contact with friends and relatives via internet reported better psychosocial factors. Future research in other cultural settings are required.
Oral lymphatic malformations: A multicenter study of 208 cases and literature review
Authors: Meirelles Daniela P. , do Couto Aline Maria , Silva Leni V. O. , Abreu Lucas G. , de Sousa Suzana C. O. M. , Custódio Marcos , Tarquinio Sandra B. C. , Batista Aline C. , Mendonça Elismauro F. , Libório‐Kimura Tatiana N. , Louredo Brendo V. R. , Romañach Mário J. , de Andrade Bruno A. B. , Nonaka Cassiano F. W. , Alves Pollianna M. , de Sena Luana S. B. , Mesquita Ricardo A. , de Aguiar Maria C. F. 
Published: September 2021

AbstractBackgroundTo evaluate the frequency and analyze demographic and clinical characteristics of individuals with a histopathological diagnosis of oral lymphatic malformations (OLMs).MethodsA multicenter study was performed, collecting biopsy record data from a consortium of Brazilian Oral and Maxillofacial Pathology Centers. A review was also conducted to compare this data with cases already available in the literature.ResultsThis study retrieved 208 cases of OLM in the multicenter study and 1035 cases in the literature review. In both, OLMs affected male and female individuals equally, with the most affected site being the tongue. Individuals ≥60 years of age were uncommonly affected. Symptomatic and larger lesions were more commonly reported in the literature review.ConclusionsThis study comprises the largest sample of OLMs to date. OLMs are rare conditions, without sex predilection. The elderly proved to be less frequently affected, and the tongue is the most commonly affected site.
Proteomic profiling of saliva reveals association of complement system with primary Sjögren's syndrome
Authors: Li Mingde , Qi Yajun , Wang Guizhen , Bu Su , Chen Ming , Yu Jiahui , Luo Tianyang , Meng Lulu , Dai Anran , Zhou Yong , Liu Shuai , Huo Xingxing 
Published: September 2021

AbstractIntroductionTo compare the saliva proteomes of experimental Sjögren's syndrome (ESS) model mice and healthy controls to identify potential diagnostic biomarkers for primary Sjögren's syndrome (pSS).MethodsProteins were extracted from the saliva of three ESS and three normal control mice using the data‐independent acquisition technique. R language was used to identify the differentially expressed proteins (DEPs). Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were performed to functionally annotate the DEPs. The protein–protein interaction (PPI) network was constructed and the core proteins were identified with the STRING website and Cytoscape software. The concentrations of Serpin family G member 1 (SERPING1), C3, complement factor H (CFH), fibrinogen alpha (FGA), and fibrinogen gamma (FGG) in saliva were determined by ELISA.ResultsA total of 1722 DEPs were identified in the saliva of the ESS mice relative to the controls, of which 50 showed significantly different expression levels between the two groups. SERPING1, C3, CFH, FGA, and FGG were significantly downregulated, and keratin 4 (Krt4) and transglutaminase 3 (TGM3) were upregulated in the saliva of ESS mice. The PPI network showed that SERPING1, C3, FGG, FGA, TGM3, and hemopexin (HPX) were the core proteins. ELISA results showed that the expression of C3, CFH, FGA, and SERPING1 were significantly downregulated in the saliva of ESS mice. However, the expression of FGG was a little downregulated but with no significant difference. SERPING1, FGG, and FGA may downregulate the complement C3 by inhibiting immune complement system, thereby promoting pSS progression.ConclusionsThe salivary proteome of ESS mice was markedly different from that of healthy controls, suggesting that salivary proteomics is a promising noninvasive diagnostic tool for pSS. SERPING1, C3, CFH, FGA, and FGG are potential biomarkers of pSS.