bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Dicarboxylic Acid Catalyst Structure on Hydrolysis of Cellulose
Model Compound D-Cellobiose in Water
Authors: Amarasekara Ananda S. , Fernando Harshica 
Published: November 2021

Background:
Polycarboxylic acids are of interest as simple mimics for cellulase enzyme catalyzed depolymerization of cellulose. In this study, DFT calculations were used to investigate the effect of structure on dicarboxylic acid organo-catalyzed hydrolysis of cellulose model compound D-cellobiose to D-glucose.

Methods:
Binding energy of the complex formed between D-cellobiose and acid (Ebind), as well as glycosidic oxygen to dicarboxylic acid closest acidic H distance were studied as key parameters affecting the turn over frequency of hydrolysis in water.

Result:
α-D-cellobiose - dicarboxylic acid catalyst down face approach showed high Ebind values for five of the six acids studied; indicating the favorability of down face approach. Maleic, cis-1,2-cyclohexane dicarboxylic, and phthalic acids with the highest catalytic activities showed glycosidic oxygen to dicarboxylic acid acidic H distances 3.5-3.6 Å in the preferred configuration.

Conclusion:
The high catalytic activities of these acids may be due to the rigid structure, where acid groups are held in a fixed geometry.
Mixed Sexually Transmitted Infections in Infertile Couples: Empirical Treatment and Influence on Semen Quality
Authors: Yasynetskyi Mykola , Banyra Oleg , Nikitin Oleg , Ventskivska Iryna , Kozlov Vadym , Kvach Mykola , Borzhievskyy Andrii 
Published: November 2021

Background:
Trichomonas vaginalis (TV), Mycoplasma genitalium (MG) and Ureaplasma
urealyticum (UU) are common sexually transmitted infections (STIs) that are diagnosed in infertile
couples (cps). In cases with their simultaneous presence in a patient (mixed STI, MSTIs),
treatment is complicated by the different sensitivity of microorganisms to antibacterial drugs. Moreover,
in cases of complicated infections, the empirical treatment should be started before obtaining
the results of drug susceptibilities.

Objective:
The objective of the current study is to find the effective and well-tolerated combination
of drugs for the empirical antibacterial treatment of mixed STIs presented by TV, MG and UU in
infertile couples. We also aimed to establish the influence of mixed STIs on semen quality.

Method:
Our prospective study included 154 infertile couples (308 patients) with confirmed symptomatic
MSTIs in one of the couples caused by the simultaneous presence of TV, MG and UU. All
couples were randomized on three groups for empirical treatment: Group 1 (n=49 cps, 98 pts) who
were treated by initial prescribing of anti-trichomoniasis drug Secnidazole, 2.0 g po followed by
Azythromycin 500 mg on day 1 continuing by 250 mg on days 2-7; Group 2 (n=52 cps, 104 pts:
Secnidazole, 2.0 g po followed by Josamycin 1000 mg bid for 12 days); Group 3 (n=53 cps, 106
pts: Secnidazole, 2.0 g po followed by Moxifloxacin 400 mg once daily for 12 days). The endpoints
were clinical and microbiological cure rates as well as the frequency of side-effects in analyzed
groups. We determined the basic parameters of the spermogram and Deoxyribonucleic acid
(DNA) fragmentation levels in 59 patients with MSTIs before and at the 3rd, 6th and 9th month after
pathogens eradication comparing them with results in 63 healthy sperm donors.

Result:
After the treatment, clinical cure rates in analyzed groups were 82.6% (Group 1) vs.
96.1% (Group 2) vs. 92.3% (Group 3). Microbiological cure rates (UU+MG) were 73.9% vs.
97.1% vs. 84.5% correspondingly (p < 0.05). TV microbiological cure rates were 97.8% vs. 98.0%
vs. 96.1% (p>0.05). Side-effects were registered in 28.6% vs. 12.5% vs. 18.9% cases correspondingly
(p<0.05). In MSTIs patients, we registered the increasing DNA fragmentation rates, leucocytes
count and decreasing semen volume, motility, vitality, sperm concentration, total spermatozoa
number and number of spermatozoa with normal morphology. At the 6th month after complete
pathogens eradication, these parameters approached normal values.

Conclusion:
At the present time, the combination of Secnidazole+Josamycin can be considered the
most effective and well-tolerated for the empirical treatment in patients with MSTIs presented by
TV, MG and UU. Complete eradication of these MSTIs in males improves their semen parameters.
Implementasi Pengembangan Wisata Kampung Keramat di Kota Malang
Authors: Islami Muhammad Fahmil , Hadi Krishno 
Published: November 2021

Artikel ini bertujuan untuk melihat bagaimana kolaborasi antara antara pemerintah, swasta maupun masyarakat dalam membangun sebuah relasi dan sinergitas dalam upaya melaksanakan pembangunan Kampung Keramat di Kota Malang. Konsep yang digunakan yaitu Collaborative Governance sebagai pisau analisa untuk mendeskripsikan topik yang diangkat. Kemudian metode yang digunakan oleh penulis adalah menggunakan penelitian deskriptif kualitatif, Sumber data yang digunakan adalah primer dan sekunder, kemudian teknik pengumpulan data yang digunakan adalah wawancara, observasi beserta dokumentasi. Subyek penelitian yang digunakan purposive sampling. Sebagai hasilnya, terdapat dua progam kegiatan yakni pertama pembangunan fisik contohnya museum, gapura makam, pergola, taman, fasilitas jalan umum dan kios sentra UKM, pengecatan gambar mural dan pembuatan papan branding dan denah lokasi. Kemudian yang non fisik adalah Pelatihan Pemasaran Produk melalui web. Secara monitoring dan evaluasi pada program pembangunan Kampung Keramat adalah dari sisi teknis dan kinerja para pihak tidak ditemukan kendala, dan pembangunan di RT. 07 100% teralisasi.
Effect of Biochar from Urban Waste and Eco-enzymes on Growth and Yield of Shallots (Allium ascalonicum, L)
Authors: Jaya Elisabet Restiana , Yohanes Parlindungan Situmeang  , Anak Agung Sagung Putri Risa Andriani  
Published: November 2021

Abstract
This study aims to determine the effect of biochar dose from urban waste and the concentration of eco-enzymes and their interactions on the growth and yield of shallots. The research was carried out in the greenhouse of the Faculty of Agriculture,Warmadewa University with an altitude of 25 m above sea level, and took place from April to June 2021. This study used a factorial randomized block design method consisting of two factors. The first factor is the dose of biochar with 4 levels (0; 5; 10; and 15 tons ha-1), while the second factor is the concentration of eco-enzyme which consists of 4 treatment levels (0; 7.5; 15.0; and 22.5 ml l-1). The results showed that the interaction between the dose of biochar and the concentration of eco-enzyme had a significant effect on the fresh weight of the stover per clump and had a very significant effect on the dry weight of the stover per clump, but had no significant effect on other variables. The treatment dose of biochar and eco-enzyme had a very significant effect on all observed variables. The results showed that the biochar and eco-enzyme treatments had a very significant effect on all observed variables. The application of biochar and eco-enzyme has a very significant effect on all observed variables. The provision of biochar treatment from urban waste was able to increase the fresh weight of tubers in the 15-ton ha-1 treatment, which was an increase of 39.40% compared to without biochar, while the highest fresh fruit weight was obtained in the eco-enzyme treatment of 22.5 ml l-1, which increased by 29.77% compared without eco-enzyme.
Keywords: Biochar; urban waste; eco-enzyme; shallots
Development and Invitro Evaluation of Solid Lipid Nano Particles Loaded Topical Gel Containing Combination of Drugs Used In The Better Therapy of Psoriasis
Authors: Suryakumari Chalakanti  , Narender Malothu  
Published: November 2021

The present research work was aimed to develop a Solid lipid nanoparticles (SLNs) based topical gel for the treatment of psoriasis. SLNs were prepared and then incorporated in a topical gel as a carrier. High-Pressure Homogenization method was used to improved drug loading capacity and drug release properties. Excipients like Compritol 888 ATO, Tween 80,Precirol ATO5, Poloxamer407, Cremophor RH40, Carpobol 934, Methyl Paraben, TEA, Distilled water were used. The optimized formulations were based on Zeta potential, analysis of particle size, differential scanning Colorimetery, scanning electron microscopy and study of Invitro drug release. The present research study revealed that the SLNs based Gel containing F4 formulation could potentially exploit as a carrier with improved drug loading capacity and drug release properties. Thus, tacrolimus loaded SLNs formulation can be beneficial in the treatment of psoriasis. It was concluded that the prepared formulation can be used for treatment of psoriasis by using the topical therapy of nanogel and this will attempt to increase the efficacy of the drug at the site of action.
Store as a Brand and Its Impact on Consumer Purchasing Behavior
Authors: Hashmi Abdullah , Nadeem Madiha 
Published: November 2021

Objectives: Stores of Apparel brands consider a driving force in boosting business and shaping consumer buying behaviors. The purpose of this study was to assess the impact of brand store image on consumer purchasing behavior in the Lahore district.
Method: A mixed-method study design was used in this study. Two apparel brands of male and female’s were selected conveniently as a sample of this study. Interviews and focus groups were used for data collection, from managements and stores’ staff, which was later analyzed thematically. The qualitative results then used to generate a questionnaire for consumers. For this purpose, data were collected from the 216 respondents. Quantitative data were analyzed while using SPSS.
Findings: Results revealed that different strategies used by brand stores for the attraction of their customers while the attributes of stores, elements of the brand, and customer-friendly policies were found important influential factors in determining the purchasing behavior of the customers in this study.
Implication: The findings of this study can be a source of implications for new store brands and suggestions for further researches.
PENERAPAN MODEL PEMBELAJARAN PROJECT BASED LEARNING UNTUK MENINGKATKAN AKTIVITAS DAN HASIL BELAJAR GAMBAR TEKNIK SISWA SMK NEGERI 1 PARIAMAN
Authors: Emputri Yulira , Ambiyar Ambiyar , Arwizet Arwizet , Rahim Bulkia 
Published: November 2021

Keberhasilan suatu pembelajaran dapat dilihat dari perolehan nilai hasil belajar siswa. Perolehan nilai gambar teknik siswa kelas X TPM SMK Negeri 1 Pariaman semester genap tahun pelajaran 2015/2016 menunjukkan belum tercapainya keberhasilan pembelajaran tersebut. Hal ini karena pembelajaran didominasi oleh guru karena menerapkan model pembelajaran dengan metode ceramah, sehingga membatasi aktivitas belajar siswa mengakibatkan hasil belajar siswa juga rendah. Tujuan penelitian ini untuk meningkatkan aktivitas dan hasil belajar siswa kelas X TPM melalui penerapan model pembelajaran project based learning di SMK Negeri 1 Pariaman. Penelitian ini merupakan penelitian tindakan kelas dimana peneliti bertindak sebagai guru yang melakukan tindakan. Penelitian ini dilaksanakan pada bulan Februari-Maret 2017. Penelitian ini terdiri dari tiga siklus yang masing-masing terdiri dari dua kali pertemuan. Data dikumpulkan menggunakan lembar observasi untuk melihat perubahan aktivitas belajar siswa setiap siklusnya dan untuk pengukur data hasil belajar siswa digunakan lembaran tes.
Berdasarkan hasil pengamatan, rata-rata aktivitas siklus I adalah 60, 47% dan pada siklus II adalah 70,055 siklus III adalah 80,16%. Selain aktivitas belajar siswa, hasil belajar juga mengalami peningkatan ketuntasan klasikal. Pada siklus I ketuntasan klasikal adalah 55,00% dengan 22 siswa tuntas dan pada siklus II adalah 70,00% dengan 28 siswa tuntas pada siklus III 80.00% dengan 32 siswa tuntas. Dapat disimpulkan penggunaan model pembelajaran project based learning dapat meningkatkan aktivitas dan hasil belajar siswa pada mata pelajaran gambar teknik di kelas X TPM SMK Negeri 1 Pariaman.
MINAT BERWIRAUSAHA MAHASISWA D3 FAKUTAS TEKNIK UNIVERSITAS NEGERI PADANG TAHUN MASUK 2016
Authors: Wahyudi Irwan , Erizon Nelvi 
Published: November 2021

Abstrak
Pengangguran terjadi karena jumlah penawaran kesempatan kerja berbanding terbalik dengan jumlah pencari kerja yang ada, baik yang disediakan oleh pemerintah maupun swasta. Untuk mengatasi masalah tersebut adalah mahasiswa dibekali dengan keterampilan berwirausaha. Penelitian ini menggunakan pendekatan kuantitatif dengan analisis data penyebaran angket/kuesioner. Skor diperoleh dari penyebaran angket kemudian diolah dan dianalisis dengan menggunakan statistic deskriptif yang dituangkan dalam bentuk pengkategorian dan persentase. Penelitian ini dilakukan di Fakultas Teknik Universitas Negeri Padang. Waktu pelaksanaan penelitian ini yaitu pada Semester Januari – Juni 2019. Sampel dari penelitian ini adalah sebanyak 201 orang yang terdiri dari 6 jurusan.Pengambilan data penelitian dilakukan dengan menyebarkan angket model skala Likert yang telah di uji validitas dan reliabilitasnya.Data yang dikumpul tersebut dianalisis secara statistic dengan bantuan computer program SPSS versi 17.0. Berdasarkan hasil penelitian dan pembahasan pada tiap-tiap indikator yang telah dikemukakan, maka secara garis besar penulis dapat menarik kesimpulan bahwa dari keseluruhan indikator didapatkan minat berwirausaha mahasiswa D3 Fakultas Teknik Universitas Negeri Padang tahun masuk 2016 adalah tinggi dengan nilai rata-rata 3,85. Antara indikator satu dengan lainnya saling menunjang sehingga secara utuh menunjukkan bagaimana minat berwirausaha mahasiswa D3 Fakultas Teknik Universitas Negeri Padang tahun masuk 2016.
PENGEMBANGAN MODUL PEKERJAAN DASAR TEKNIK MESIN BERBASIS PROJECT BASED LEARNING DI JURUSAN TEKNIK PEMESINAN SMK NEGERI 5 PADANG
Authors: Alfonis Winaldi , Helmi Nofri Helmi , Refdinal Refdinal , K Arwizet 
Published: November 2021

Terbatasnya media pebelajaran dapat menyebabkan tidak maksimalnya kompetensi siswa dalam pembelajaran. Tujuan penelitian ini adalah untuk menghasilkan modul pembelajaran pekerjaan dasar teknik mesin berbasis Project Based Learning yang valid, praktis dan layak digunakan di jurusan teknik mesin SMK Negeri 5 Padang. Model Project Based Learning memberikan kesempatan kepada siswa untuk meningkatkan kemampuan pemecahan masalah dan meningkatkan kompetensi pengetahuan, keterampilan, sikap dan produktifitas. Metode pengembangan yang digunakan dalam penelitian ini adalah metode pengembangan 4-D (Four D-Model) yang terdiri atas empat fase utama dalam Define (mendefenisikan), Design (merancang), Develop (mengembangkan) dan Disseminate (menyebarluaskan). Data penelitian ini diperoleh dari hasil validasi 1 orang Dosen ahli materi dan 1 orang Dosen ahli media dan data praktikalitas diperoleh dari responden 1 orang Guru dan 30 orang siswa. Berdasarkan hasil penelitian pengembangan ini diperoleh persentase hasil validasi oleh ahli materi mendapatkan nilai 86,75% termasuk kedalam kategori sangat valid dan hasil validasi oleh ahli media mendapakan nilai 85,00% termasuk kedalam kategori sangat valid. Hasil Praktisitas modul pembelajaran respon Guru mendapatkan persentase nilai 96,25% termasuk kedalam kategori sangat praktis dan hasil respon Siswa mendapatkan nilai 95,75% termasuk kedalam kategori sangat praktis. Berdasarkan hasil validasi dan praktikalitas tersebut dapat di simpulkan bahwa modul pembelajaran ini layak untuk digunakan sebagai media pembelajaran.
Kata Kunci : Pengembangan, Modul, Project Based Learning, Metode
PENGARUH MEDIA PEMBELAJARAN VIDEO TUTORIAL TERHADAP HASIL BELAJAR SISWA PADA MATA PELAJARAN GAMBAR TEKNIK MESIN DI SMK NEGERI 5 PADANG
Authors: Susanti Sasma , Ambiyar Ambiyar , Nurdin Hendri , Nabawi Rahmat Azis 
Published: November 2021

Metode belajar yang digunakan di SMK Negeri 5 Padang adalah gabungan antara tatap muka dan online atau blended learning. Metode tersebut membuat guru kesulitan dalam menyampaikan materi pembelajaran dengan menggunakan media konvensional dan juga membuat minat belajar siswa menurun faktor tersebut berdampak pada hasil belajar siswa. Hasil belajar siswa yang masih rendah menuntut guru untuk dapat membuat proses pembelajaran menjadi lebih menarik dan efektif. Penggunaan media seperti video tutorial dapat meningkatkan minat belajar siswa, proses pembelajaran lebih efektif dan guru lebih mudah dalam menyampaikan materi pembelajaran. Penelitian ini.bertujuan untuk mengetahui hasil belajar dengan menggunakan media pembelajaran video tutorial dan media konvensional. Metode penelitian yang digunakan adalah adalah metode eksperimen. Penelitian ini hanya membandingkan posttest kelas eksperimen dan kelas kontrol. Metode pengumpulan data menggunakan tes. Tes digunakan untuk memperoleh hasil belajar siswa yang menjadi populasinya adalah kelas X TPM di SMK Negeri 5 Padang yang berjumlah 58 siswa dan dijadikan sampel semuanya. Tes sebelum diujikan terlebih dahulu diuji cobakan kepada pernah mendapatkan perlakuan yang sama“yaitu kelas XI TPM setelah itu baru di ujikan ke kelas X TPM. Hasil dari pengujian Independent Samples Test nilai sig. (2 tailed) sebesar 0,002 dengan demikian jelas terlihat bahwa nilai sig. (2 tailed) < 0,05 berarti adanya perbedaan yang signifikan atau Terdapat pembedaan hasil belajar dengan menggunakan media konvensional dengan media video tutorial. Perbedaan hasil belajar tersebut dapat dikatakan bahwa adanya pengaruh media pembelajaran video tutorial terhadap hasil belajar siswa pada mata pelajaran Gambar Teknik Mesin kelas X TPM.
Von der Ostseeriviera zu grünen Wintersportorten: Deutschlandtourismus in Zeiten des Klimawandels
Authors: Knoll Gabriele M. 
Published: November 2021

Tropische Temperaturen an deutschen Küsten im Sommer – schneefreie Skipisten in den Mittelgebirgen und Alpen im Winter. Der Klimawandel verändert den Tourismus – das ist gewiss! Er wirkt sowohl auf das touristische Angebot als auch auf die Nachfrage. Zudem können touristische Dienstleistungen selbst den Klimawandel verschärfen. Gabriele M. Knoll beleuchtet das Phänomen Klimawandel aus touristischer Sicht. Dabei berücksichtigt sie gleichermaßen Forschung, Trends und Strategien von Politik und Verbänden sowie einzelner Destinationen in Deutschland. Darüber hinaus stellt sie konkret Verlierer und Gewinner der aktuellen Klimaveränderung vor und zeigt auf, wie Destinationen mit den sich verändernden Rahmenbedingungen umgehen. Daraus lassen sich viele Anregungen für die Praxis ableiten.
Does the lifestyle of patients with psoriasis affect their illness?
Authors: Owczarczyk-Saczonek Agnieszka , Kasprowicz-Furmańczyk Marta , Krajewska-Włodarczyk Magdalena , Griffiths Christopher E. M. 
Published: November 2021

Abstract
Psoriasis is one of the most common chronic, incurable inflammatory skin diseases, affecting 2–4% of the general population. Etiopathogenesis of this disease remains unclear. It is widely considered to be a multifactorial disorder caused by the interaction between inherited susceptibility alleles and environmental risk factors, such as lifestyle, diet, stimulants, foci of inflammation, and psychological factors. The widespread prevalence of psoriasis is a very significant health and socioeconomic problem. Treatment of psoriasis is based on relieving the acute symptoms of the disease. Despite the implementation of many therapeutic options, including biological treatment, effectiveness of these options is not always sufficient, or in some patients it is not satisfactory. In order to properly control the symptoms of the disease, the patient should be told that the therapeutic effect is achieved not only by pharmacotherapy but also by introducing appropriate healthy habits in everyday life. This article discusses the importance of patient-controlled factors that affect the severity of psoriasis. Theimportance of regular exercise, smoking avoidance, and reduced alcohol consumption is explained, as well as the importance for psoriasis treatment of psychotherapy and spa therapy. Understanding the essence of these factors in the treatment of psoriasis is important in achieving satisfactory therapeutic effects.
An Output Sensitivity Problem for a Class of Fractional Order Discrete-Time Linear Systems
Authors: Benfatah Youssef , El Bhih Amine , Rachik Mostafa , Lafif Marouane 
Published: November 2021

Abstract
Consider the linear discrete-time fractional order systems with uncertainty on the initial state

{

Δ

α

x

i
+
1

=
A

x

i

+
B

u

i

,

i
≥
0

x

0

=

τ

0

+

τ
⌢

0

∈

ℝ

n

,

τ
⌢

0

∈
Ω
,

y

i

=
C

x

i
,

i
≥
0

\left\{ {\matrix{{{\Delta ^\alpha }{x_{i + 1}} = A{x_i} + B{u_i},} \hfill & {i \ge 0} \hfill \cr {{x_0} = {\tau _0} + {{\mathord{\buildrel{\lower3pt\hbox{$\scriptscriptstyle\frown$}}\over \tau } }_0} \in {\mathbb{R}^n},} \hfill & {{{\mathord{\buildrel{\lower3pt\hbox{$\scriptscriptstyle\frown$}}\over \tau } }_0} \in \Omega ,} \hfill \cr {{y_i} = C{x_{i,}}\,\,\,i \ge 0} \hfill & {} \hfill \cr } } \right.

where A, B and C are appropriate matrices, x0 is the initial state, yi is the signal output, α the order of the derivative, τ0 and

τ
⌢

0

{\mathord{\buildrel{\lower3pt\hbox{$\scriptscriptstyle\frown$}}\over \tau } _0}

are the known and unknown part of x0, respectively, ui = Kxi is feedback control and Ω ⊂ ℝn is a polytope convex of vertices w1, w2, . . . , wp. According to the Krein–Milman theorem, we suppose that

τ
⌢

0

=

∑

j
=
1

p

α

j

w

j

{\mathord{\buildrel{\lower3pt\hbox{$\scriptscriptstyle\frown$}}\over \tau } _0} = \sum\limits_{j = 1}^p {{\alpha _j}{w_j}}

for some unknown coefficients α1 ≥ 0, . . . , αp ≥ 0 such that

∑

j
=
1

p

α

j

=
1

\sum\limits_{j = 1}^p {{\alpha _j} = 1}

. In this paper, the fractional derivative is defined in the Grünwald–Letnikov sense. We investigate the characterisation of the set χ(

τ
⌢

0

{\mathord{\buildrel{\lower3pt\hbox{$\scriptscriptstyle\frown$}}\over \tau } _0}

, ϵ) of all possible gain matrix K that makes the system insensitive to the unknown part

τ
⌢

0

{\mathord{\buildrel{\lower3pt\hbox{$\scriptscriptstyle\frown$}}\over \tau } _0}

, which means

χ

(

τ
⌢

0

,
∈

)

=

{

K
∈

ℝ

m
×
n

/

‖

∂

y

i

∂

α

j

‖

≤
∈
,
∀
j
=
1
,
…
,
p
,

∀
i
≥
0

}

\chi \left( {{{\mathord{\buildrel{\lower3pt\hbox{$\scriptscriptstyle\frown$}}\over \tau } }_0}, \in } \right) = \left\{ {K \in {\mathbb{R}^{m \times n}}/\left\| {{{\partial {y_i}} \over {\partial {\alpha _j}}}} \right\| \le \in ,\forall j = 1, \ldots ,p,\,\forall i \ge 0} \right\}

, where the inequality

‖

∂

y

i

∂

α

j

‖

≤
∈

\left\| {{{\partial {y_i}} \over {\partial {\alpha _j}}}} \right\| \le \in

showing the sensitivity of yi relatively to uncertainties

{

α

j

}

j
=
1

p

\left\{ {{\alpha _j}} \right\}_{j = 1}^p

will not achieve the specified threshold ϵ > 0. We establish, under certain hypothesis, the finite determination of χ(

τ
⌢

0

{\mathord{\buildrel{\lower3pt\hbox{$\scriptscriptstyle\frown$}}\over \tau } _0}

, ϵ) and we propose an algorithmic approach to made explicit characterisation of such set.