bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Recovery after Intramyocardial Injection of Adipose-Derived Stromal Cells Assessed by Cardiac Magnetic Resonance Imaging
Authors: Konstanty-Kalandyk Janusz , Sadowski Jerzy , Kędziora Anna , Urbańczyk-Zawadzka Małgorzata , Baran Jakub , Banyś Paweł , Kapelak Bogusław , Piątek Jacek 
Published: April 2021

Aims. A major clinical concern is the continuous increase in the number of patients diagnosed with advanced coronary artery disease, ischemic heart failure, and refractory angina, and one of the most promising treatment options for these conditions is stem cell-based therapy. The aim of this study was to assess the functional improvement following intramyocardial injection of adipose-derived stromal cells, using cardiac magnetic resonance. Methods and Results. Thirteen patients with ischemic heart failure, reduced left ventricular ejection fraction, refractory angina, and who have been disqualified from any form of direct revascularization were enrolled in the study with transthoracic autologous adipose-derived stromal cell implantation. All patients underwent cardiac magnetic resonance prior to the procedure and after 12 months of follow-up. A significant increase in stroke volume (

83.1
±
8.5

mL

vs

93.8
±
13.8

mL

,

p
=
0.025

) and stroke volume index (

43.3
±
7.6

mL
/

m

2

vs

48.7
±
9.1

mL
/

m

2

,

p
=
0.019

), a statistical trend toward an increase in left ventricle ejection fraction (

36.7
±
13.2

vs

39.7
±
14.9

,

p
=
0.052

), and cardiac output improvement (

5.0
±
0.7

vs

5.5
±
0.9

,

p
=
0.073

) was observed in the patient postprocedure. Enhanced relative regional thickening was noted in the segments with adipose-derived stromal cell implantation. Conclusions. Intramyocardial adipose-derived stromal cell implantation is a promising therapeutic option for selected, symptomatic patients with ischemic heart failure, who have preserved myocardial viability despite being unsuitable for direct revascularization.
Cervical Cancer Immunotherapy: Facts and Hopes
Authors: Ferrall Louise , Lin Ken Y. , Roden Richard B.S. , Hung Chien-Fu , Wu T.-C. 
Published: April 2021

AbstractIt is a sad fact that despite being almost completely preventable through human papillomavirus (HPV) vaccination and screening, cervical cancer remains the fourth most common cancer to affect women worldwide. Persistent high-risk HPV (hrHPV) infection is the primary etiologic factor for cervical cancer. Upward of 70% of cases are driven by HPV types 16 and 18, with a dozen other hrHPVs associated with the remainder of cases. Current standard-of-care treatments include radiotherapy, chemotherapy, and/or surgical resection. However, they have significant side effects and limited efficacy against advanced disease. There are a few treatment options for recurrent or metastatic cases. Immunotherapy offers new hope, as demonstrated by the recent approval of programmed cell death protein 1–blocking antibody for recurrent or metastatic disease. This might be augmented by combination with antigen-specific immunotherapy approaches, such as vaccines or adoptive cell transfer, to enhance the host cellular immune response targeting HPV-positive cancer cells. As cervical cancer progresses, it can foster an immunosuppressive microenvironment and counteract host anticancer immunity. Thus, approaches to reverse suppressive immune environments and bolster effector T-cell functioning are likely to enhance the success of such cervical cancer immunotherapy. The success of nonspecific immunostimulants like imiquimod against genital warts also suggest the possibility of utilizing these immunotherapeutic strategies in cervical cancer prevention to treat precursor lesions (cervical intraepithelial neoplasia) and persistent hrHPV infections against which the licensed prophylactic HPV vaccines have no efficacy. Here, we review the progress and challenges in the development of immunotherapeutic approaches for the prevention and treatment of cervical cancer.
The Date and Provenance of Targum Pseudo-Jonathan: The Evidence of Pirqe deRabbi Eliezer and the Chronicles of Moses
Authors: McDowell Gavin 
Published: April 2021

Abstract
The date of Targum Pseudo-Jonathan has been the occasion of much controversy, with propositions ranging from the Second Temple period to the time of the Crusades. Related to the Targum is the late midrashic work Pirqe deRabbi Eliezer (eighth century), but the nature of this relationship is disputed. The present article proposes that the Targum depends unilaterally on PRE, based on two principal arguments: 1. PRE does not refer to common Targumic traditions in Pseudo-Jonathan; and 2. Pseudo-Jonathan uses sources that post-date PRE, namely the Chronicles of Moses, which was written around the eleventh century. The Targum’s use of late sources places its redaction long after the conclusion of the first millennium. The author proposes a twelfth-century Italian origin, which corresponds to the earliest evidence for the Targum.
Myanmar’s Manufacturing Exports After the Lifting of Economic Sanctions
Authors: Taguchi Hiroyuki , Soe Thet Mon 
Published: April 2021

This article aims to evaluate Myanmar’s exports of manufacturing products by using a gravity trade model for emerging ASEAN economies. The main focus of this study is to assess whether Myanmar’s manufacturing exports have recovered in terms of the gravity trade standard of the other emerging ASEAN countries for the post-sanction period of 2013–2018. Unlike the previous studies, this article contributes to the literature by targeting the post-sanction period and by applying both in-sample and out-of-sample estimation methods to ensure the consistency and robustness of their results. The main findings from the gravity trade model estimation are summarised as follows: first, Myanmar’s manufacturing exports for the post-sanction period are still significantly below the level of the gravity trade standard. Second, the downward deviation from the standard could be explained by the two Myanmar-specific factors, that is, the low institutional quality and the Dutch Disease effect in Myanmar’s exports to Western countries, but not fully in those to Asian countries. The additional factor for the deviation against Asian countries might come from Myanmar’s sluggish participation in the international production networks. JEL Codes: F14, O53
Temporal Sensitivity and Latency During Teleoperation: Using Track Clearance to Understand Errors in Future Projection
Authors: Scholcover Federico , Gillan Douglas J. 
Published: April 2021

Objective This study investigates the role of individual differences in time perception on task performance during teleoperation with latency. Background Long distance teleoperation induces latency, causing performance issues for the operator. Previous research demonstrated that individual differences in time perception predicted performance on a similar task, having participants navigate a radio controlled (RC) car around a track. This work extends the relationship into routes of varying course width to test whether differences in time perception predict movement over-/underestimation. Method Participants completed a time estimation task and a route navigation task while experiencing latency. In the time estimation task, participants estimated the duration of multiple visual stimuli (2 s or less). In the route navigation task, participants moved a virtual cube across a route. Each trial varied in the amount of latency and the amount of horizontal clearance in the track (4–10 m for a 1.2-m-long/wide cube). Results The results showed fairly consistent latency by time estimation and latency by clearance interaction effects on a wide set of trial-level variables, such as completion time, and action-level performance variables, such as time spent moving per move event. However, the results were not consistently in the predicted direction. Conclusion Results suggest that clearance and timing affect performance across latency, at both the overall level (i.e., trial completion time) and at the action level (time spent moving). An open question remains as to how these contextual factors affect movement strategy selection.
Point-of-care testing for HIV and sexually transmitted infections reveals risky behavior among men at gambling centers in Uganda”
Authors: Kiragga Agnes N , Bwanika John M , Kyenkya Joshua , Banturaki Grace , Kigozi Joanita , Musinguzi Davis , Namimbi Florence , Chander Geetanjali , Reynolds Steven J , Manabe Yukari C 
Published: April 2021

In sub-Saharan Africa (SSA), men are generally difficult to engage in healthcare programs. However, sports gambling centers in SSA can be used as avenues for male engagement in health programs. We offered point-of-care HIV and syphilis testing for men located at five gambling centers in Uganda and assessed HIV risky sexual behavior. Among 507 men, 0.8% were HIV-positive and 3.8% had syphilis. Risky sexual behavior included condomless sex with partner(s) of unknown HIV status (64.9%), having multiple sexual partners (47.8%), engaging in transactional sex (15.5%), and using illicit drugs (9.3%). The majority at 64.5% were nonalcohol consumers, 22.9% were moderate users, and 12.6% had hazardous consumption patterns. In 12 months of follow-up, the incidence rate of syphilis was 0.95 (95% CI: 0.82-1.06) among 178 men. Thus, men in SSA have a high prevalence of syphilis and risky sexual behavior which should be more effectively addressed to reduce the risk of HIV acquisition.
Syphilis among men who have sex with men attending a large HIV clinic in Trinidad
Authors: Edwards Robert Jeffrey , John Isshad , Todd Selena , Lavia Leon-Omari , Musa David , Edwards Jonathan , Boyce Gregory 
Published: April 2021

A chart review study was conducted to determine the prevalence of syphilis and explore the associated risk factors among men who have sex with men (MSM) who attended a large HIV clinic in Trinidad during the period January–December 2019. Patients were routinely screened for syphilis annually, and demographic, clinical, and laboratory data were extracted from the medical records. Descriptive and bivariate analyses were performed, and factors significantly associated with a syphilis diagnosis were assessed using multivariate logistic regression. During the period, 218 MSM were seen, age range 19–67 years, and median age 34.0 years. The prevalence of syphilis was 41.3% (90/218), and 71.1% (64//90) of these infections were asymptomatic. Multivariate analysis using logistic regression showed that MSM living with HIV in the 30–34 years old-age group (OR, 4.32; 95% CI, 1.04–18.02), and those with a previous history of treated syphilis (OR, 10.18; 95% CI, 4.60–22.53) were more likely to be diagnosed with syphilis. The prevalence of syphilis is high among MSM attending the HIV clinic in Trinidad, and most of these infections were asymptomatic; hence, targeted and sustained interventions to reduce syphilis transmission are urgently required. Repeat episodes of syphilis may play a role in the transmission dynamics of syphilis in MSM.
ARID5B rs10821936 and rs10994982 gene polymorphism and susceptibility to juvenile systemic lupus erythematosus and lupus nephritis
Authors: Mosaad Youssef M , Hammad Ayman , AlHarrass Mohamed F , Sallam Rehab , Shouma Amany , Hammad Enas , Ahmed Engy Osman , Abdel-Azeem Heba A , Sherif Doaa , Fawzy Iman , Elbahnasawy Amany , Abdel Twab Hosam 
Published: April 2021

Background The prevalence of SLE and the spectrum of clinical manifestations vary widely in different races and geographical populations. Objective To investigate the possible role of ARID5B rs10821936 and rs10994982 polymorphism as a risk factor for the development of SLE in children (jSLE) and to evaluate their role in relation to clinical manifestations especially lupus nephritis (LN). Methods DNA extraction and Real-time PCR genotyping of ARID5B rs10821936 and rs10994982 were done for 104 jSLE and 282 healthy controls. Results The C allele and C containing genotypes (CC, CT and CC+CT) of ARID5B rs10821936 were higher in children with SLE (p = 0.009, OR = 1.56, 0.037, OR = 2.35, 0.016, OR = 1.81 and 0.008 OR = 1.88 respectively). ARID5B rs10994982 alleles, genotypes and haplotypes are not associated with jSLE (p > 0.05). The ARID5B rs10821936 and rs10994982 genotypes showed non-significant associations with LN, proliferative versus non proliferative and biopsy grades (p > 0.05). Conclusion ARID5B rs10821936 SNP may be a susceptibility risk factor for juvenile SLE in the studied cohort of Egyptian children.
Suspect AI: Vibraimage, Emotion Recognition Technology and Algorithmic Opacity
Authors: Wright James 
Published: April 2021

Vibraimage is a digital system that quantifies a subject’s mental and emotional state by analysing video footage of the movements of their head. Vibraimage is used by police, nuclear power station operators, airport security and psychiatrists in Russia, China, Japan and South Korea, and has been deployed at two Olympic Games, a FIFA World Cup and a G7 Summit. Yet there is no reliable empirical evidence for its efficacy; indeed, many claims made about its effects seem unprovable. What exactly does vibraimage measure and how has it acquired the power to penetrate the highest profile and most sensitive security infrastructure across Russia and Asia? I first trace the development of the emotion recognition industry, before examining attempts by vibraimage’s developers and affiliates scientifically to legitimate the technology, concluding that the disciplining power and corporate value of vibraimage are generated through its very opacity, in contrast to increasing demands across the social sciences for transparency. I propose the term ‘suspect artificial intelligence (AI)’ to describe the growing number of systems like vibraimage that algorithmically classify suspects/non-suspects, yet are themselves deeply suspect. Popularising this term may help resist such technologies’ reductivist approaches to ‘reading’—and exerting authority over—emotion, intentionality and agency.
The Relationship Between Maxillary Growth and Speech in Children With a Unilateral Cleft Lip and Palate at 5 Years of Age
Authors: Fell Matthew , Medina Jibby , Fitzsimons Kate , Seifert Miriam , Roberts Anne , Russell Craig , Deacon Scott 
Published: April 2021

Objective: This study sought to investigate the association between maxillary growth and speech outcomes for children with a repaired unilateral cleft lip and palate (UCLP) at 5 years of age. Participants: In all, 521 children (180 females and 341 males) with a nonsyndromic complete UCLP, born between 2007 and 2012 in England, Wales, and Northern Ireland were included in this study. Outcome Measures: Maxillary growth was analyzed using dental models scored by the 5-Year-Olds’ index, and perceptual speech analyses were scored by the Cleft Audit Protocol for Speech – Augmented rating. Results: Forty-one percent of the children achieved good maxillary growth (scores 1 and 2 on 5-Year-Old’ index). Fifty percent of the children achieved normal speech (achieving UK speech standard 1). Maxillary growth was not found to have an impact on speech outcome when described by the 3 UK National Cleft Lip and Palate Speech Audit Outcome Standards. Analysis according to individual speech parameters showed dentalizations to be less prevalent in children with good maxillary growth compared to fair and poor growth ( P = .001). The remaining speech parameters within resonance, nasal airflow, and articulation categories were not significantly associated with maxillary growth. Conclusion: The findings from this study suggest that children with a history of complete UCLP, who have poor maxillary growth, are not at a higher risk of having major speech errors compared to children with good or fair maxillary growth at 5 years of age.
Surgical outcomes of modified capsular tension ring and intraocular lens implantation in Marfan syndrome with ectopia lentis
Authors: Chen Zexu , Zhang Min , Deng Michael , Chen Tianhui , Chen Jiahui , Zheng Jialei , Jiang Yongxiang 
Published: April 2021

Objective: To evaluate surgical outcomes of modified capsular tension ring (MCTR) and intraocular lens (IOL) implantation in eyes of Marfan syndrome (MFS). Methods: This retrospective case series included MFS patients receiving MCTR transscleral fixation and IOL in-the-bag implantation. The MCTR was sutured to the sclera through a sulcus by 9–0 polypropylene with the modified knotless Z-suture technique. Main outcomes were visual acuity and postoperative complications. Results: A total of 109 MFS patients (187 eyes) had the surgery. Patients were 15.47 ± 14.36 years old and followed up for 10.07 ± 8.99 months. MCTR and IOL implantations were performed in 174 eyes (93.05%). The postoperative BCVA (LogMAR) was 0.24 ± 0.24 (1 month), 0.26 ± 0.20 (3 months), 0.22 ± 0.20 (6 months), 0.20 ± 0.19 (12 months) and 0.25 ± 0.32 (over 12 months), which was significantly better than preoperatively (0.63 ± 0.35) ( p < 0.001). Major complications included posterior capsular opacification (PCO) in 41 eyes (23.56%) and decentered anterior capsular opacification (ACO) in 15 eyes (8.62%). The mean occurrence time was 9.44 ± 7.08 and 8.87 ± 15.08 months respectively. Other complications included transient intraocular pressure elevation in seven eyes (4.02%), retinal detachment in two eyes (1.15%), cystoid macula edema in one eye (0.57%), and endophthalmitis in one eye (0.57%). No eye had suture breakage or IOL dislocation. Conclusions: The visual improvement is significant in eyes of MFS undergoing MCTR transscleral fixation and IOL in-the-bag implantation. The long-term monitoring of complications is warranted, especially in the first-two years.
Chorionic bump: Progression to a subamniotic hematoma
Authors: Galleguillos Claudia , Sepulveda Waldo 
Published: April 2021

Introduction A chorionic bump is an increasingly recognized ultrasound finding in first-trimester scans, which has been associated with early pregnancy loss. In ongoing second-trimester pregnancies, however, chorionic bumps usually resolve over time with no deleterious effect on the fetus. In this report, we describe the incidental ultrasound detection of a chorionic bump in early pregnancy and its progression to a subamniotic hematoma in the second trimester of pregnancy that persisted as such until delivery. Case Report A round, echogenic mass protruding from the choriodecidual surface measuring 13 × 11 × 8 mm was first identified during a transvaginal scan at 6.3 weeks’ gestation. Subsequent follow-up scan at 8.3 weeks revealed an increase in the size of the chorionic bump to 25 × 20 × 19 mm, which remained stable as determined by the routine late first-trimester scan. At the second-trimester scan, a subamniotic hematoma was identified in the surface of the placenta, close to the insertion of the umbilical cord. Subsequently, the pregnancy proceeded uneventfully. Discussion The etiopathology and clinical significance of a chorionic bump remain unclear. The case herein reported demonstrates that a chorionic bump can grow considerably without having a deleterious effect on the early embryo and, occasionally, can persist throughout pregnancy as a subamniotic hematoma. Conclusion A chorionic bump can occasionally progress to a subamniotic hematoma from the second trimester onwards. This observation further supports the hypothesis that a chorionic bump is the result of choriodecidual bleeding. An alternative explanation for the development of subamniotic hematomas is proposed.
Early discontinuation and dose reduction of adjuvant chemotherapy in stage III colon cancer patients
Authors: Boakye Daniel , Jansen Lina , Halama Niels , Chang-Claude Jenny , Hoffmeister Michael , Brenner Hermann 
Published: April 2021

Background: The benefit of chemotherapy in colon cancer patients is well documented but depends largely on whether patients complete the planned treatment regimen. We evaluated predictors of early discontinuation (EDChemo) and dose reduction of chemotherapy, especially the role of adverse treatment effects, in stage III patients who received adjuvant chemotherapy. Methods: Stage III colon cancer patients who were diagnosed in 2003–2014 and recruited into a population-based study in Germany and received FOLFOX [5-fluorouracil (5-FU), leucovorin (LV), and oxaliplatin], capecitabine monotherapy (CapMono), or 5-FU/LV were included. We assessed determinants of EDChemo and dose reduction using multivariable logistic regression. Also, we estimated proportions of EDChemo and dose reduction that are attributable to adverse effects using attributable fractions. Results: EDChemo and dose reduction rates were 52% and 17% for FOLFOX, 28% and 9% for CapMono, and 45% and 6% for 5-FU/LV, respectively. Predictors of EDChemo were low-grade tumor and treatment in a medium-volume hospital (for FOLFOX), obesity (for CapMono), and increasing age, T4 stage, and treatment in a medium-volume hospital (for 5-FU/LV). Adverse effects were particularly strongly associated with EDChemo and contributed to about 63%, 51%, and 32% of EDChemo of FOLFOX, CapMono, and 5-FU/LV, respectively. Of the various adverse effects, gastrointestinal events showed the strongest associations with EDChemo and accounted for about 7%, 26%, and 20% of EDChemo of FOLFOX, CapMono, and 5-FU/LV, respectively. Adverse effects were, moreover, a strong determinant of dose reduction and accounted for about 82% of all cases. Conclusions: EDChemo is common in stage III colon cancer patients receiving chemotherapy and more than half of the cases of EDChemo and dose reduction are due to adverse treatment effects. Further research should address the potential for reducing EDChemo and dose reduction rates by close monitoring of patients for early signs and enhanced management of adverse effects, especially gastrointestinal events.
Prediction Models in Degenerative Spine Surgery: A Systematic Review
Authors: Lubelski Daniel , Hersh Andrew , Azad Tej D. , Ehresman Jeff , Pennington Zachary , Lehner Kurt , Sciubba Daniel M. 
Published: April 2021

Study Design: Systematic review. Objectives: To review the existing literature of prediction models in degenerative spinal surgery. Methods: Review of PubMed/Medline and Embase databases was conducted to identify articles between January 1, 2000 and March 1, 2020 that reported prediction model performance for outcomes following elective degenerative spine surgery. Results: Thirty-one articles were included. Twenty studies were of thoracolumbar, 5 were of cervical, and 6 included all spine patients. Five studies were externally validated. Prediction models were developed using machine learning (42%) and logistic regression (42%) as well as other techniques. Web-based calculators were included in 45% of published articles. Various outcomes were investigated, including complications, infection, length of stay, discharge disposition, reoperation, readmission, disability score, back pain, leg pain, return to work, and opioid dependence. Conclusions: Significant heterogeneity exists in methods used to develop prediction models of postoperative outcomes after degenerative spine surgery. Most internally validate their scores, but a few have been externally validated. Areas under the curve for most models range from 0.6 to 0.9. Techniques for development are becoming increasingly sophisticated with different machine learning tools. With further external validation, these models can be deployed online for patient, physician, and administrative use, and have the potential to optimize outcomes and maximize value in spine surgery.