bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Hall effect and toroidal flow on the plasmoid formation and incomplete reconnection in a low resistivity plasma in tokamak
Authors: Zhang W. , Ma Z.W. , Zhang H.W. 
Published: October 2021

Abstract
The nonlinear resistive-kink mode in the low resistivity plasma in tokamak is investigated through the three-dimensional, toroidal, and nonlinear Hall-MHD code CLT. It is found that, without the two-fluid effect and the toroidal flow, the system can evolve into a steady-state with the saturated main m/n = 1/1 magnetic island and the co-existing large secondary island. The main m/n = 1/1 magnetic island cannot push the hot core plasma out of the q = 1 surface as it does in Kadomstev’s model, and the reconnection is incomplete. However, with the two-fluid effect or the toroidal flow, the nonlinear behaviors of the resistive-kink mode could be essentially different. The two-fluid effect and the toroidal flow can break the symmetry during the plasmoid formation, which destroys the balance between the main m/n = 1/1 magnetic island and the large secondary island. The large secondary island is then merged into the main m/n = 1/1 island. After that, the main m/n = 1/1 island finally occupies the whole mix region, and all magnetic flux in the mix region is reconnected. A similar simulation study has been done in periodic cylindrical geometry (Günter et al 2015 Plasma Phys. Control. Fusion
57 014017), while our work is done in tokamak toroidal geometry. The toroidal effect has also been investigated, and we find that the widths of the main 1/1 island and the secondary island slightly increase with increasing aspect ratios.
Asymptotic reversibility of thermal operations for interacting quantum spin systems via generalized quantum Stein’s lemma
Authors: Sagawa Takahiro , Faist Philippe , Kato Kohtaro , Matsumoto Keiji , Nagaoka Hiroshi , Brandão Fernando G S L 
Published: October 2021

Abstract
For quantum spin systems in any spatial dimension with a local, translation-invariant Hamiltonian, we prove that asymptotic state convertibility from a quantum state to another one by a thermodynamically feasible class of quantum dynamics, called thermal operations, is completely characterized by the Kullback–Leibler (KL) divergence rate, if the state is translation-invariant and spatially ergodic. Our proof consists of two parts and is phrased in terms of a branch of the quantum information theory called the resource theory. First, we prove that any states, for which the min and max Rényi divergences collapse approximately to a single value, can be approximately reversibly converted into one another by thermal operations with the aid of a small source of quantum coherence. Second, we prove that these divergences collapse asymptotically to the KL divergence rate for any translation-invariant ergodic state. We show this via a generalization of the quantum Stein’s lemma for quantum hypothesis testing beyond independent and identically distributed situations. Our result implies that the KL divergence rate serves as a thermodynamic potential that provides a complete characterization of thermodynamic convertibility of ergodic states of quantum many-body systems in the thermodynamic limit, including out-of-equilibrium and fully quantum situations.
Manipulation of spin transport in graphene/transition metal dichalcogenide heterobilayers upon twisting
Authors: Pezo Armando , Zanolli Zeila , Wittemeier Nils , Ordejón Pablo , Fazzio Adalberto , Roche Stephan , Garcia Jose H 
Published: October 2021

Abstract
Proximity effects between layered materials trigger a plethora of novel and exotic quantum transport phenomena. Besides, the capability to modulate the nature and strength of proximity effects by changing crystalline and interfacial symmetries offers a vast playground to optimize physical properties of relevance for innovative applications. In this work, we use large-scale first principles calculations to demonstrate that strain and twist-angle strongly vary the spin–orbit coupling (SOC) in graphene/transition metal dichalcogenide heterobilayers. Such a change results in a modulation of the spin relaxation times by up to two orders of magnitude. Additionally, the relative strengths of valley-Zeeman and Rashba SOC can be tailored upon twisting, which can turn the system into an ideal Dirac–Rashba regime or generate transitions between topological states of matter. These results shed new light on the debated variability of SOC and clarify how lattice deformations can be used as a knob to control spin transport. Our outcomes also suggest complex spin transport in polycrystalline materials, due to the random variation of grain orientation, which could reflect in large spatial fluctuations of SOC fields.
Numerical simulation and experimental research on an inductively coupled RF plasma cathode
Authors: XU Zongqi , WANG Pingyang , HUA Zhiwei , CONG Shiyuan , YU Shengnan 
Published: October 2021

Abstract
In this study, numerical simulation and discharge current tests were conducted on an inductively coupled radio frequency (RF) plasma cathode. Numerical simulations and experimental measurements were performed to study the factors influencing the electron extraction characteristics, including the gas type, gas flow, input power and extracting voltage. The simulation results were approximately consistent with the experimental results. We experimentally found that the RF input power mainly determines the extracted electron current. An electron current greater than 1 A was acquired at 270 W (RF input power), 2.766 sccm (xenon gas). Our results prove that an inductively coupled RF plasma cathode can be reasonable and feasible, particularly for low power electric propulsion devices.
Analytical application of H
2
O
2
-induced chiroptical graphitic carbon dots
Authors: Das Smita , Gogoi Sudarshan , Singh Naveen Kumar , Goswami Pranab 
Published: October 2021

Abstract
Carbon dots (CDs) have emerged as efficient peroxidase mimics in recent years. However, to further increase its efficiency as peroxidase-mimic, it is also desirable to understand the modification of CD’s geometry during the catalytic reaction. Herein, we focused on the change in material property of the CDs upon their reaction with H2O2 during the peroxidase reaction. D-(+)-glucose was transformed into chiroptical CDs bearing peroxidase-like activity and can be used to detect H2O2 with a limit of detection of 630 μM. The addition of H2O2 to the CDs resulted in its increased molecular orderliness leading to the introduction of polycrystallinity without affecting its peroxidase-like activity.
Invited Commentary: Comparing Approaches to Measuring Structural Racism
Authors: Jahn Jaquelyn L 
Published: October 2021

AbstractIn their article, Adkins-Jackson et al. (Am J Epidemiol. 2022;191(4):539–547) provide much needed insight on current approaches and challenges to epidemiologic research on structural racism. The authors encourage researchers to consider how structural racism is conceptualized in extant and future work, and whether existing measures accurately reflect the multidimensional nature of structural racism. In the spirit of continuing this conversation, I expand upon approaches to measuring structural racism. I compare the merits and challenges of scales, indexes, indicators, and policy-based measures of structural racism for use in epidemiologic research.
Effects of Antihypertensive Deprescribing Strategies on Blood Pressure, Adverse Events, and Orthostatic Symptoms in Older Adults: Results From TONE
Authors: Juraschek Stephen P , Cluett Jennifer L , Belanger Matthew J , Anderson Timothy S , Ishak Anthony , Sahni Shivani , Millar Courtney , Appel Lawrence J , Miller Edgar R , Lipsitz Lewis A , Mukamal Kenneth J 
Published: October 2021

Abstract

Background
The Trial of Nonpharmacologic Interventions in the Elderly (TONE) demonstrated the efficacy of weight loss and sodium reduction to reduce hypertension medication use in older adults. However, the longer-term effects of drug withdrawal (DW) on blood pressure (BP), adverse events, and orthostatic symptoms were not reported.

Methods
TONE enrolled adults, ages 60–80 years, receiving treatment with a single antihypertensive and systolic BP (SBP)/diastolic BP &lt;145/&lt;85 mm Hg. Participants were randomized to weight loss, sodium reduction, both, or neither (usual care) and followed up to 36 months; ~3 months postrandomization, the antihypertensive was withdrawn and only restored if needed for uncontrolled hypertension. BP and orthostatic symptoms (lightheadedness, feeling faint, imbalance) were assessed at randomization and throughout the study. Two physicians independently adjudicated adverse events, masked to intervention, classifying symptomatic (lightheadedness, dizziness, vertigo), or clinical events (fall, fracture, syncope).

Results
Among the 975 participants (mean age 66 years, 48% women, 24% black), mean (±SD) BP was 128 ± 9/71 ± 7 mm Hg. Independent of assignment, DW increased SBP by 4.59 mm Hg (95% confidence interval [CI]: 3.89, 5.28) compared with baseline. There were 113 adverse events (84 symptomatic, 29 clinical), primarily during DW. Compared with usual care, combined weight loss and sodium reduction mitigated the effects of DW on BP (β = −4.33 mm Hg; 95% CI: −6.48, −2.17) and reduced orthostatic symptoms long term (odds ratio = 0.62; 95% CI: 0.41, 0.92), without affecting adverse events (hazard ratio = 1.81; 95% CI: 0.90, 3.65). In contrast, sodium reduction alone increased risk of adverse events (hazard ratio = 1.75; 95% CI: 1.04, 2.95), mainly during DW.

Conclusions
In older adults, antihypertensive DW may increase risk of symptomatic adverse events, highlighting the need for caution in withdrawing their antihypertensive medications.

Clinical trials registration
Trial Number NCT00000535.
Cognitive task analysis-based training in surgery: a meta-analysis
Authors: Edwards Thomas C , Coombs Alexander W , Szyszka Bartosz , Logishetty Kartik , Cobb Justin P 
Published: October 2021

Abstract

Background
Reduced hands-on operating experience has challenged the development of complex decision-making skills for modern surgical trainees. Cognitive task analysis- (CTA-)based training is a methodical solution to extract the intricate cognitive processes of experts and impart this information to novices. Its use has been successful in high-risk industries such as the military and aviation, though its application for learning surgery is more recent. This systematic review aims to synthesize the evidence evaluating the efficacy of CTA-based training to enable surgeons to acquire procedural skills and knowledge.

Methods
The PRISMA guidelines were followed. Four databases, including MEDLINE, EMBASE, Web of Science and Cochrane CENTRAL, were searched from inception to February 2021. Randomized controlled trials and observational studies evaluating the training effect of CTA-based interventions on novices' procedural knowledge or technical performance were included. Meta-analyses were performed using a random-effects model.

Results
The initial search yielded 2205 articles, with 12 meeting the full inclusion criteria. Seven studies used surgical trainees as study subjects, four used medical students and one study used a combination. Surgical trainees enrolled into CTA-based training groups had enhanced procedural knowledge (standardized mean difference (SMD) 1.36 (95 per cent c.i. 0.67 to 2.05), P &lt; 0.001) and superior technical performance (SMD 2.06 (95 per cent c.i. 1.17 to 2.96), P &lt; 0.001) in comparison with groups that used conventional training methods.

Conclusion
CTA-based training is an effective way to learn the cognitive skills of a surgical procedure, making it a useful adjunct to current surgical training.
Tocilizumab suppresses the pro-carcinogenic effects of breast cancer-associated fibroblasts through inhibition of the STAT3/AUF1 pathway
Authors: Al-Jomah Naif , Al-Mohanna Falah H , Aboussekhra Abdelilah 
Published: October 2021

Abstract
Active breast cancer-associated fibroblasts (CAFs), the most influential cells in breast tumor microenvironment, express/secrete high levels of the proinvasive/metastatic interleukin-6 (IL-6). Therefore, we have tested here the effect of the IL-6 receptor (IL-6R) inhibitor tocilizumab (TCZ; Actemra) on different active breast CAFs. We have shown that TCZ potently and persistently suppresses the expression of various CAF biomarkers, namely α-SMA, SDF-1 as well as the STAT3 pathway and its downstream target AUF1. TCZ also inhibited the proliferation, migration and invasion abilities of active breast CAF cells. Additionally, TCZ repressed the ability of CAF cells in promoting epithelial-to-mesenchymal transition, and enhancing the migratory/invasive and proliferative capacities of breast cancer cells in vitro. Importantly, these findings were confirmed in orthotopic humanized breast tumors in mice. Furthermore, TCZ suppressed the expression of the pro-angiogenic factor VEGF-A and its transactivator HIF-1α in CAF cells, and consequently inhibited the angiogenic-promoting effect of active CAFs both in vitro and in orthotopic tumor xenografts. These results indicate that inhibition of the IL-6/STAT3/AUF1 pathway by TCZ can normalize active breast CAFs and suppress their paracrine pro-carcinogenic effects, which paves the way toward development of specific CAF-targeting therapy, badly needed for more efficient breast cancer treatments.
Functional assessment of somatic STK11 variants identified in primary human non-small cell lung cancers
Authors: Donnelly Liam L , Hogan Tyler C , Lenahan Sean M , Nandagopal Gopika , Eaton Jenna G , Lebeau Meagan A , McCann Cai L , Sarausky Hailey M , Hampel Kenneth J , Armstrong Jordan D , Cameron Margaret P , Sidiropoulos Nikoletta , Deming Paula , Seward David J 
Published: October 2021

Abstract
Serine/Threonine Kinase 11 (STK11) encodes an important tumor suppressor that is frequently mutated in lung adenocarcinoma. Clinical studies have shown that mutations in STK11 resulting in loss of function correlate with resistance to anti-PD-1 monoclonal antibody therapy in KRAS-driven non-small cell lung cancer (NSCLC), but the molecular mechanisms responsible remain unclear. Despite this uncertainty, STK11 functional status is emerging as a reliable biomarker for predicting non-response to anti-PD-1 therapy in NSCLC patients. The clinical utility of this biomarker ultimately depends upon accurate classification of STK11 variants. For nonsense variants occurring early in the STK11 coding region, this assessment is straightforward. However, rigorously demonstrating the functional impact of missense variants remains an unmet challenge. Here we present data characterizing four STK11 splice-site variants by analyzing tumor mRNA, and 28 STK11 missense variants using an in vitro kinase assay combined with a cell-based p53-dependent luciferase reporter assay. The variants we report were identified in primary human NSCLC biopsies in collaboration with the University of Vermont Genomic Medicine group. Additionally, we compare our experimental results with data from 22 in silico predictive algorithms. Our work highlights the power, utility and necessity of functional variant assessment and will aid STK11 variant curation, provide a platform to assess novel STK11 variants and help guide anti-PD-1 therapy utilization in KRAS-driven NSCLCs.
The stability of tastant detection by mouse lingual chemosensory tissue requires Regulator of G protein Signaling-21 (RGS21)
Authors: Schroer Adam B , Branyan Kayla W , Gross Joshua D , Chantler Paul D , Kimple Adam J , Vandenbeuch Aurelie , Siderovski David P 
Published: October 2021

Abstract
The T1R and T2R families of G protein-coupled receptors (GPCRs) initiate tastant perception by signaling via guanine nucleotide exchange and hydrolysis performed by associated heterotrimeric G proteins (Gαβγ). Heterotrimeric G protein signal termination is sped up by Gα-directed GTPase-accelerating proteins (GAPs) known as the Regulators of G protein Signaling (RGS proteins). Of this family, RGS21 is highly expressed in lingual epithelial cells and we have shown it acting in vitro to decrease the potency of bitterants on cultured cells. However, constitutive RGS21 loss in mice reduces organismal response to GPCR-mediated tastants—opposite to expectations arising from observed in vitro activity of RGS21 as a GAP and inhibitor of T2R signaling. Here, we show reduced quinine aversion and reduced sucrose preference by mice lacking RGS21 does not result from post-ingestive effects, as taste-salient brief-access tests confirm the reduced bitterant aversion and reduced sweetener preference seen using two-bottle choice testing. Eliminating Rgs21 expression after chemosensory system development, via tamoxifen-induced Cre recombination in eight week-old mice, led to a reduction in quinine aversive behavior that advanced over time, suggesting that RGS21 functions as a negative regulator to sustain stable bitter tastant reception. Consistent with this notion, we observed downregulation of multiple T2R proteins in the lingual tissue of Rgs21-deficient mice. Reduced tastant-mediated responses exhibited by mice lacking Rgs21 expression either since birth or in adulthood has highlighted the potential requirement for a GPCR GAP to maintain the full character of tastant signaling, likely at the level of mitigating receptor downregulation.
Effectiveness of BNT162b2 mRNA Coronavirus Disease 2019 (COVID-19) Vaccine Against Acquisition of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Among Healthcare Workers in Long-Term Care Facilities: A Prospective Cohort Study
Authors: Muhsen Khitam , Maimon Nimrod , Mizrahi Ami , Bodenheimer Omri , Cohen Dani , Maimon Michal , Grotto Itamar , Dagan Ron 
Published: October 2021

AbstractBackgroundWe assessed vaccine effectiveness (VE) of BNT162b2 mRNA coronavirus disease 2019 (COVID-19) vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) acquisition among healthcare workers (HCWs) of long-term care facilities (LTCFs).MethodsThis prospective study, in the framework of the “Senior Shield” program in Israel, included routine weekly nasopharyngeal SARS-CoV-2 RT-PCR testing from all LTCF HCWs since July 2020. All residents and 75% of HCWs were immunized between December 2020 and January 2021. The analysis was limited to HCWs adhering to routine testing. Fully vaccinated (14+ days after second dose; n = 6960) and unvaccinated (n = 2202) HCWs were simultaneously followed until SARS-CoV-2 acquisition or end of follow-up, 11 April 2021. Hazard ratios (HRs) for vaccination versus no vaccination were calculated (Cox proportional hazards regression models, adjusting for sociodemographics and residential-area COVID-19 incidence). VE was calculated as (1– HR) × 100. RT-PCR cycle threshold (Ct) values were compared between vaccinated and unvaccinated HCWs.ResultsAt &gt;14 days post–second dose, 40 vaccinated HCWs acquired SARS-CoV-2 (median follow-up, 66 days; cumulative incidence, 0.6%) versus 84 unvaccinated HCWs (median follow-up, 43 days; cumulative incidence, 5.1%) (HR, .11; 95% CI, .07–.17; unadjusted VE, 89%; 95% CI, 83–93%). Adjusted VE &gt;7 and &gt;14 days post–second dose were similar. The median PCR Ct targeting the ORF1ab gene among 20 vaccinated and 40 unvaccinated HCWs was 32.0 versus 26.7, respectively (P value  = .008).ConclusionsVE following 2 doses of BNT162b2 against SARS-CoV-2 acquisition in LTCF HCWs was high. The lower viral loads among SARS-CoV-2–positive HCWs suggest further reduction in transmission.
Isolation of a Novel Recombinant Canine Coronavirus From a Visitor to Haiti: Further Evidence of Transmission of Coronaviruses of Zoonotic Origin to Humans
Authors: Lednicky John A , Tagliamonte Massimiliano S , White Sarah K , Blohm Gabriela M , Alam Md Mahbubul , Iovine Nicole M , Salemi Marco , Mavian Carla , Morris J Glenn 
Published: October 2021

Abstract
We isolated a novel coronavirus from a medical team member presenting with fever and malaise after travel to Haiti. The virus showed 99.4% similarity with a recombinant canine coronavirus recently identified in a pneumonia patient in Malaysia, suggesting that infection with this virus and/or recombinant variants occurs in multiple locations.
Performance Characteristics of a Clinical Decision Support Tool for Disease Complications in Crohn’s Disease
Authors: Siegel Corey A , Siegel Lori S , Dubinsky Marla C , Targan Stephan , Braun Jonathan , Landers Carol , Bilsborough Janine , Princen Fred , Lasch Karen , Candela Ninfa , McGovern Dermot P B , Dervieux Thierry 
Published: October 2021

Abstract

Background
Patients with Crohn’s disease (CD) are at risk of complications. Performance characteristics of a decision support tool assessing the risk of CD complications were evaluated.

Methods
CDPATH (formerly called the Personalized Risk and Outcome Prediction Tool [PROSPECT]) was calibrated and validated in 2 cohorts. Tool prediction of disease characteristics was assessed using Cox regression and Harrell’s C-statistic.

Results
All associations of CD complications and CDPATH components were significant except perianal location. There was a significant association between individualized risk assessment scores and CD complications in both cohorts.

Conclusion
CDPATH is validated as a clinical decision support tool for assessing the risk of CD complications.
At-C-RNA database, a one-stop source for information on circRNAs inArabidopsis thalianain a unified format
Authors: Nowis Katarzyna , Jackowiak Paulina , Figlerowicz Marek , Philips Anna 
Published: October 2021

AbstractCircular RNAs (circRNAs) are a large class of noncoding RNAs with functions that, in most cases, remain unknown. Recent genome-wide analysis of circRNAs using RNA-Seq has revealed that circRNAs are abundant and some of them conserved in plants. Furthermore, it has been shown that the expression of circRNAs in plants is regulated in a tissue-specific manner. Arabidopsis thaliana circular RNA database is a new resource designed to integrate and standardize the data available for circRNAs in a model plant A. thaliana, which is currently the best-characterized plant in terms of circRNAs. The resource integrates all applicable publicly available RNA-seq datasets. These datasets were subjected to extensive reanalysis and curation, yielding results in a unified format. Moreover, all data were normalized according to our optimized approach developed for circRNA identification in plants. As a result, the database accommodates circRNAs identified across organs and seedlings of wild-type A. thaliana and its single-gene knockout mutants for genes related to splicing. The database provides free access to unified data and search functionalities, thus enabling comparative analyses of A. thaliana circRNAs between organs, variants and studies for the first time.Database URLhttps://plantcircrna.ibch.poznan.pl/