bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ground Motions Induced by Pore Pressure Changes at the Szentes Geothermal Area, Se Hungary
Authors: Békési Eszter , Fokker Peter , Candela Thibault , Szanyi János , Wees Jan-Diederik van 
Published: July 2021

Abstract
Excessive thermal water volumes have been extracted from porous sedimentary rocks in the Hungarian part of the Pannonian Basin. Thermal water production in Hungary increased significantly from the early 70’s. Regional-scale exploitation of geothermal reservoirs without re-injection resulted in basin-scale pressure drop in the Upper Pannonian (Upper Miocene) sediments, leading to compaction and ground subsidence.We investigated surface deformation at the Szentes geothermal filed, SE Hungary, where the largest pressure decline occurred. Subsequently, hydraulic head recovery in the western part of the geothermal reservoir has initiated from the mid-90’s. We obtained data from the European Space Agency’s Envisat satellites to estimate the ground motions for the period of 2002-2010. We applied inverse geomechanical modelling to estimate reservoir properties and processes. We constrained the model parameters using the Ensemble Smoother with Multiple Data Assimilation, which allowed us to incorporate large amounts of surface movement observations in a computationally efficient way. Ground movements together with the modelling results show that uplift of the Szentes geothermal field occurred during the observation period. Since no injection wells were operated at Szentes before 2018, and production temperatures remained relatively constant through the entire production period, we explain ground uplift with pore pressure increase due to natural recharge. Additionally, subsidence of the north-eastern part of the field exists, in agreement with a minor negative pressure source. The estimated (de)compaction coefficients suggest that permanent deformation of the geothermal reservoir occurred during the main depletion period, from ~1970 until the late 90’s. Permanent deformation associated with the prolonged decrease of reservoir pressures occurred locally in the eastern part of the field, until at least 2007. The improved parametrization enables better forecasting of the reservoir behaviour and facilitates the assessment of future subsidence scenarios. This study thus demonstrates the effectiveness of InSAR-based ground motion data and inverse geomechanical modelling for the monitoring of geothermal reservoirs and the establishment of a sustainable production scheme.
Fermented Rye With Agaricus Subrufescens and Mannan-rich Hydrolysate Based Feed Additive to Modulate Post-weaning Piglet Immune Response
Authors: de Groot Nienke , Fariñas Fernando , Faba Lluís , Hambrecht Ellen , Cabrera-Gomez Carolina Gisel , Pallares Francisco , Ramis Guillermo 
Published: July 2021

Abstract
Background The process of weaning in piglets is often associated with an increased inflammation response in the intestine and compromised intestinal integrity and morphology favoring a delay in intestinal maturation and a predisposal to diseases. Research has shown the potential of different nutritional strategies to reduce the production of pro-inflammatory cytokines, with the main goal to manipulate health and performance of pigs. Promising examples of nutritional strategies are fungal fermented products and their derivatives which are described to contain several compounds that may play a role in gastrointestinal health and pathogenic bacteria control. Products from Agaricus subrufescens mushroom are reported to contain prophylactic and therapeutic properties including antimicrobial and immunomodulatory. Results This study analysed the post-weaning immune status in intestinal tissue and blood of piglets, with the objective to evaluate the gastrointestinal health and immune modulation response induced by a blend of mannan-rich hydrolyzed copra meal and fermented rye with A. subrufescens. The results showed that in piglets post-weaning, the feed additive stimulates an immunomodulation effect most evident at 15 days post-weaning, with lower expression of cytokines Interferon (IFN) γ, Interleukin (IL) 1 α, IL-1 β, IL-6, IL-8, IL-10 and Transforming Growth Factor (TGF) β in jejunum, accompanied with an increase in peripheral blood mononuclear cells (PBMC) cytokine gene expression of IL-1β, IL-6, IL-8, IL-10, IL-12p35 (IL-12α), IL-12p40 (IL-12β), Tumor Necrosis Factor (TNF) α, IFN-α, and TGF-β. In piglets fed the feed additive, the quantity of Immunoglobulin (Ig) A producing cells in jejunum, ileum was reduced on day 15 and 30 postweaning, and on day 30 and 45 post-weaning in colon tissue. Intestinal histomorphology demonstrated a villus height reduction in jejunum and increase in ileum on day 15, while increased villous height in jejunum and ileum on day 30. Natural Killer (NK) cells were increased at day 15 post-weaning in the piglets fed the feed additive.Conclusion This study implies the potential of the blend including mannan-rich hydrolyzed copra meal and fermented rye with A. subrufescens on immune modulation in the intestine of post-weaning piglets.
Numerical Prediction and Experimental Investigation of Residual Stresses in Sequential Milling of GH4169 Considering Initial Stress Effect
Authors: Yao Gonghou , Liu Zhanqiang , Song Qinghua , Wang Bing , Cai Yukui 
Published: July 2021

Abstract
Residual stresses affect the service life and causes the deformation of machined parts. Therefore, the study on development of residual stresses during machining operation is very important. For this, an analytical and numerical models have been developed to predict the residual stresses for single-step machining operation. However, the parts are usually machined with a serial of production processes. A numerical model for predicting residual stress in sequential side milling GH4169 considering initial stress was proposed in this research. The initial residual stress distribution due to previous-step milling was considered in the proposed model. It was assumed that this initial residual stress value changed with the depth from the machined surface, while the residual stress on the identical horizontal plane was assumed with uniform distribution. The proposed numerical simulation model could predict the stress value of the machined surface, the stress value of the compression valley and the residual stress distribution in the depth direction beneath the machined surface with high accuracy. Experimental investigations of sequential side milling GH4169 were conducted and the generated residual stresses were measured. The distribution trend and influence rule of residual stress between two sequential milling steps were analyzed. The residual stress distribution beneath the surface showed a spoon-shaped pattern. The thickness of the residual stress influence layer (RSIL) after the current milling step was affected by the depth of cut and the RSIL thickness of the previous milling step. The numerical model could predict the thickness of RSIL and optimize the depth of cut in sequential side milling.
Label-free proteomic comparative analysis of cow placental proteins enzymatic hydrolysis by different proteases
Authors: Shen Liuhong , zhang yue , you liu chao , zhu ying kun , shen yu , lv shang kui , yu shu min , deng jun liang , peng guang neng , zuo zhi cai , ma xiao ping , zhong zhi jun , ren zhi hua , zong xiao lan , Cao Sui Zhong 
Published: July 2021

Abstract
Background
Novel findings in biochemical characteristics of placenta can bring new insight for further studies on the potential markers of physiological/pathological pregnancy or function of placenta. In this study, we compared the proteome of dairy cow placenta enzymatic hydrolysis by different proteases using a label-free mass spectrometry approach.
Results
In total, 541, 136 and 86 proteins were identified in trypsin group (TRY), pepsin group (PEP) and papain group (PAP), respectively. 432 differentially expressed proteins (DEPs) were identified between the proteomes of PAP and TRY. 421 DEPs were identified between PEP and TRY, while 136 DEPs were identified between PEP and PAP. Further analysis of the up-regulated DEPs and down-regulated DEPs of each comparison showed the proteins identified by papain are mostly derived from extracellular matrix and collagen and enriched in relaxin signaling pathway, advanced glycation end products-receptor of advanced glycation end products (AGE-RAGE) signaling pathway in diabetic complications. Moreover, pepsin digestion resulted in more muscle-related proteins, which enriched in lysosome, platelet activation, cardiac muscle contraction,bacterial invasion of epithelial cell and small cell lung cancer. Trypsin mainly enzymatically degrades extracellular matrix, blood particles, and cell surface proteins which enriched in arginine and proline metabolism, olfactory transduction proteasome, protein processing in endoplasmic reticulum, pyruvate metabolism and arrhythmogenic right ventricular cardiomyopathy (ARVC).
Conclusions
In summary, these data provide insights into the selection of protease in dairy cow placenta proteomics.
Ethnobotanical Investigation on Medicinal Plants Traditionally Used Against Human Ailments in Ensaro District, North Shewa Zone, Amhara Regional State, Ethiopia
Authors: Asfaw Asaye , Lulekal Ermias , Bekele Tamrat , Debella Asfaw , Abebe Abiy , Degu Sileshi 
Published: July 2021

Abstract
IntroductionPeople all over the world have been using medicinal plants to treat various ailments and diseases throughout history. It is still common in developing countries. Because is easily accessible, affordable, and trusted by the communities. Although there are several ethnobotanical studies on medicinal plants in Ethiopia, the number of medicinal plant species and indigenous knowledge documented is still low compared to the high diversity of culture and habitats.MethodsEthnobotanical data were collected during the 13th of February 2019 and the 26th of October 2020 through Semi-structured interviews, field observation, a guided field walk, and focus group discussionsResultthe study documented 142 medicinal plant species distributed in 125 genera and 56 families which used to treat 52 ailments. Most of these species were collected from wild habitats. The most used plant families were Fabaceae (14) followed by lamiaceae (9) and Solanaceae (9). Most of these medicinal plants were herbs followed by shrubs.ConclusionThe study revealed a relatively high diversity of medicinal plants that indicated the existence of indigenous knowledge of using medicinal plants to treat ailments and diseases. The findings of this study supported up the idea that indigenous knowledge of using medicinal plants is still alive in highly degraded areas. To make sustainable use of these medicinal plants in the study area, local people must collaborate with natural resource administrators to manage them before they become seriously threatened. Both ex-situ and In-situ conservation strategies should be combined and employed urgently for optimal conservation results
Diffusion Coefficient Analysis of Aluminum Electrolysis Spent Cathode as Anode Material For Lithium-ion Battery
Authors: Huang Wenlong , Peng Jiaxin , Li Jie , Hou Xueyang , Zhang Xingliang , Fang Zhao 
Published: July 2021

Abstract
The aluminum electrolysis spent cathode (SC) was treated by hydrothermal method and used as anode material for lithium-ion battery. The purified SC material shows excellent electrochemical performance. In order to understand the diffusion behavior of Li+ in the SC electrode, the diffusion coefficient of Li+ in the SC electrode was systematically analyzed by galvanostatic intermittent titration technique (GITT), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). The results show that the diffusion coefficient (DLi+) of Li+ in SC electrode is calculated by CV is 2.2292×10-11 cm2·s-1, which is calculated by GITT and EIS ranges are 4.2286×10-13-2.9667×10-10 cm2·s-1, 4.05×10-13-3.87×10-12 cm2·s-1, respectively. SC electrode exhibits better Li+ diffusion kinetics compared to commercial graphite (CG). In addition, the full cell of LiNi0.5Co0.2Mn0.3O2/SC also shows excellent cycle performance. After 80 cycles at 1 C (1 C=172 mA·g-1), the specific discharge capacity of LiNi0.5Co0.2Mn0.3O2/SC full-cell can reach 94.7 mAh·g-1, and the capacity retention can reach 98.13%. The fast lithium-ion diffusion rate and high discharge capacity provide a feasible direction for the high value utilization of aluminum electrolysis spent cathode.
Enriched Environment Priors to TET1 Hippocampal Administration for Regulating Cognitive and Psychiatric Behaviors via Glial Reactivity in Chronic Cerebral Hypoperfusion Models
Authors: Li Yaqing , Qu Chujie , Song Hao , Li Tian , Zheng Jiaxin , Wu Liyang , Yan Nao , Xu Linling , Qu Changhua , Zhang JunJian 
Published: July 2021

Abstract
Increased understanding of chronic cerebral hypoperfusion (CCH) has gradually been conscious of consisting a common etiologic mechanism for cognitive and psychiatric disturbances, and remains a matter to acquire a potential new therapeutic avenue benefiting from it. In the present study, we found genetical treatment with overexpressing a catalytic domain of human TET1 (AAV-hTET1) or enriched environment (EE) was sufficient for stimulating adult hippocampal neurogenesis (AHN). However, promoting ANH could not deal with the cognitive dysfunction and depressive-like behaviors in CCH rats. Notably, healthy local brain environment with elevated BDNF and less astroglia reaction was conducive to improve cognitive dysfunction. Meanwhile, astrocytes were involved in the regulating process of neurons, presynaptic function and microglia in the cognition. In addition, depressive disturbances were determined by glial activation containing astrocytes and microglia, BDNF levels, as well as neuronal and presynaptic function. To support this, we investigated astroglia and microglia activation was strongly correlated with severe depressive symptoms. Importantly, causal mediation analysis showed significant mediation by presence of reactive glial cells in the relation between neural plasticity and depressive symptoms. Finally, we compared the efficiency of genetical therapy and EE to treat cognitive dysfunction and depressive-related disorders in CCH rats. We showed EE performed better than hTET1 treatment for cognitive deficits and depression, and glial activation was important for the discrepancy for cognition, with glial reactivity and presynaptic function devoting to the different efficiency for depression. These results were important for our understanding of disease mechanisms and provided valuable tools for the overall management of CCH patients.
Memristive Electromagnetic Induction Effects on Hopfield Neural Network
Authors: Chen Chengjie , Min Fuhong , Zhang Yunzhen , Bao Bocheng 
Published: July 2021

Abstract
Due to the existence of membrane potential differences, the electromagnetic induction flows can be induced in the interconnected neurons of Hopfield neural network (HNN). To express the induction flows, this paper presents a unified memristive HNN model using hyperbolic-type memristors to link neurons. By employing theoretical analysis along with multiple numerical methods, we explore the electromagnetic induction effects on the memristive HNN with three neurons. Three cases are classified and discussed. When using one memristor to link two neurons bidirectionally, the coexisting bifurcation behaviors are disclosed with respect to the memristor coupling strength. When using two memristors to link three neurons, the antimonotonicity phenomena of periodic and chaotic bubbles are yielded, and initial-related multistable patterns are emerged. When using three memristors to link three neurons end to end, the extreme event owning riddled basin of attraction is demonstrated. In addition, we develop the printed circuit board (PCB)-based hardware experiments by synthesizing the memristive HNN and the experimental results well confirm the memristive electromagnetic induction effects.
Neonatal Mortality Rates in Brazilian Health Facilities: from 2005 to 2017
Authors: Baroni Lais , Salles Rebecca , Ogasawara Eduardo , Boccolini Patricia de Moraes Mello , Lima Jefferson Costa , Boccolini Cristiano Siqueira 
Published: July 2021

Abstract
Objectives: Neonatal mortality is a global public health problem. The efforts to reduce child mortality are one of the 2030 Agenda for Sustainable Development goals. The availability of neonatal mortality rates (NMR) data in Brazilian health facilities is crucial to understanding the dynamic, identify gaps, and provide information to allocate resources and actions to reduce NMR at the health facility level. The objective is to offer an integrated dataset containing monthly data in a historical series from 2007 to 2017 with information on all births, neonatal deaths, and NMR (total, early, and late components) enriched with the municipality’s information. Data description: Dataset with historical data with information on the number of births, the neonatal deaths, the neonatal mortality rate (including early and late components), and geographic information for each health facility in Brazil, comprising the years between 2005 and 2017.
An Automatic Classification Method of Sleep Apnea Events Based on EEG Frequency Sub-band Division
Authors: Wang Yao , Wang Xiaohong , Li Weiming , Ji Siyu , Yang Tianshun , Zhuangwen Xiao , Zhao Xiaoyun , Wang Jinhai 
Published: July 2021

Abstract
Sleep apnea is a kind of sleep disorder with a high prevalence rate. It is manifested as the abnormal stop of breathing during sleep and is highly dangerous to human health. The purpose of this research is to find a simple, and effective feature extraction method that can able to distinguish obstructive apnea events, central apnea events, and normal breathing events. Unlike conventional methods, the method illustrated in this study used the Infinite Impulse Response Butterworth Band pass filter to divide the Electroencephalogram (EEG) signal into 5, 7, 9 or 11 frequency sub-bands and then used the Welch method to extract the power features of these frequency sub-band signals, which were subsequently used as classifier input. Random forest, K-nearest neighbors and bagging classifiers were investigated. The results showed that in several different frequency sub-band division methods of EEG signals, the features extracted from the EEG signal that was divided into 11 frequency sub-bands were more conducive to the classification of sleep apnea events. The random forest classifier achieved the highest average accuracy, macro F1 and kappa coefficient in three types of events, which were 90.43%, 90.38% and 0.88, respectively. Compared with existing methods, the method used in the present study has higher classification performance.
Superspreading in the COVID-19 Epidemic and Autointerference of Viruses
Authors: Shlyakhover Vladimir , Iabluchanskyi Mykola , Dimaschko Juri 
Published: July 2021

Abstract
It has been shown that autointerference of viruses limiting their replication leads to the emergence of a new stable asymptomatic state of the infected organism. This state gives viruses the ability to superspread and make a main contribution to the epidemic. We assume this to be responsible for the superspreading in the COVID-19 epidemic.
The Impact of Different Arrangements of Molecular Chains in Terms of
Low and High Shear Rate’s Viscosities on Heat and Mass Flow of Nonnewtonian
Shear thinning Fluids
Authors: Hassan Mohsan , Ahmad Ashfaq , Faisal Abrar , Javid Khurram , Khan Salahuddin , Khan Rawaiz 
Published: July 2021

Background:
Non-newtonian fluids, especially shear thinning fluids, have several
applications in the polymer industry, food industry, and even everyday life. The viscosity of shear
thinning fluids is decreased by two or three orders of magnitude due to the alignment of the
molecules in order when the shear rate is increased, and it cannot be ignored in the case of polymer
processing and lubrication problems.

Objective:
So, the effects of viscosities at the low and high shear rates on the heat and mass
boundary layer flow of shear thinning fluid over moving belts are investigated in this study. For
this purpose the generalized Carreau model of viscosity relate to shear rate is used in the
momentum equation. The Carreau model contains the five parameters: low shear rate viscosity,
high shear rate viscosity, viscosity curvature, consistency index, and flow behavior index. For the
heat flow, the expression of the thermal conductivity model similar to the viscosity equation due to
the non-Newtonian nature of the fluid is used in the energy equation.

Methods:
On the mathematical model of the problem, boundary layer approximations are applied
and then simplified by applying the similarity transformations to get the solution. The solution of
the simplified equations is obtained by numerical technique RK-shooting method. The results are
compared with existing results for limited cases and found good agreement.

Results:
The results in the form of velocity and temperature profiles under the impact of all the
viscosity’s parameters are obtained and displayed in graphical form. Moreover, the boundary layer
parameters such as the thickness of the regions, momentum thickness, and displacement thickness
are calculated to understand the structure of the boundary layer flow of fluid.

Conclusion:
The velocity and temperature of the fluid are decreased and increased respectively by
all viscosity’s parameters of the model. So, the results of the boundary layer fluid flow under
rheological parameters will not only help engineers to design superior chemical equipment but also
help improve the economy and efficiency of the overall process.
Natural Products and some Semi-synthetic Analogues as Potential TRPV1
Ligands for Attenuating Neuropathic Pain
Authors: Naik Gaurav Gopal , Uniyal Ankit , Chouhan Deepak , Tiwari Vinod , Sahu Alakh N. 
Published: July 2021

:
Natural products and leads inspired by them have acted as a probe for successful drug discovery for many decades. Pain is an obnoxious sensory and emotional experience associated with potential tissue damage. It affects the quality of life of patients to a greater extent. Despite the availability of several agents targeting TRP receptors, none of them can proficiently alleviate neuropathic pain. TRPV1 is a prospective target for treating neuropathic pain as it is recognized to modulate the pain circuitry at the periphery and the central level. In this review, we have discussed several natural molecules, such as Capsaicinoids, Capsinoids, Piperine, Eugenol, Scutigeral, Ginsenosides, Cinnamaldehyde, Camphor, Shogaol, Gingerols, Zingerone, Allicin, Evodiamine, Allylisothiocyanate, Cannabidiol, Ricinoleic acid, Isovelleral, Capsazepine, Thapsigargin, Pellitorine, Yohimbine, Curcumin and some semi-synthetic analogues that activate TRPV1 channels and consequently, can be further harnessed for the treatment of neuropathic pain.
Impact of ErbB Receptors and Anticancer Drugs against Breast Cancer:
A Review
Authors: Sahu Ankita , Verma Saurabh , Varma Meena , Yadav Manoj Kumar 
Published: July 2021

:
Human EGFR (epidermal growth factor receptor) family of tyrosine kinase receptors consists of four members, ErbB1-4. Abnormalities in the ErbB family characterize a variety of human cancers, including breast cancer. Tyrosine kinase is recruited by the activated EGFR cell surface receptor, which transmitted signals from the receptor to interact with intracellular signaling pathways and regulate cellular functions and biological processes. Targeting the intracellular signaling pathways has been aided in the drug development that was already in use and more continually being developed. The review article highlights the function of ErbB receptors/ligands, their role in signaling pathways, effective targeted drugs, and a combination of targeted drug strategies in the treatment of breast cancer that could be leading to the novel combination of anticancer drug delivery systems.