bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zoledronic acid as adjuvant therapy in neovascular age-related macular degeneration: a randomised controlled pilot study
Authors: Husum Yngvil Solheim , Moe Morten Carstens , Fagerland Morten Wang , Eriksen Erik Fink , Jørstad Øystein Kalsnes 
Published: December 2024

AimsTo assess the feasibility of a study protocol for a randomised controlled trial of zoledronic acid (ZA) as adjuvant therapy for neovascular age-related macular degeneration (nAMD).MethodsIn this 1-year, randomised, double-blinded, placebo-controlled pilot study, nAMD patients were allocated 1:1 to receive intravenous ZA 5 mg or placebo at baseline and after 6 months in addition to intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy following a treat-and-extend regimen. Bevacizumab was the first-line anti-VEGF drug, but eyes with refractory nAMD were switched to aflibercept. The primary outcome was mean change in best-corrected visual acuity (BCVA).Results40 participants enrolled in the study, with 20 allocated to each treatment group. 38 participants received both study infusions, and all participants completed the final assessment. Mean (SD) change in BCVA was 7.5 (9.5) letters in the ZA group and −0.5 (11.5) letters in the control group; the between-group difference was 8.0 letters (95% CI: 1.5 to 15.0 letters). There were no between-group differences in mean change in central retinal thickness, refractory nAMD proportion or mean number of injections.ConclusionIt is feasible to conduct a randomised controlled trial of ZA as adjuvant therapy for nAMD in terms of recruitment and adherence to the pilot study protocol. We found a possible visual benefit of ZA that is worth further investigation. To clarify the relationship between ZA and the need for intravitreal injections, we recommend amending the protocol by omitting switching of the anti-VEGF drug. Due to the limited sample size of the pilot study, the estimates of treatment effect are not meant to be confirmatory and should be interpreted with caution.Trial registration number2019-001492-37 (EudraCT), 04304755 (NCT).
Reaching experts for enhanced referral (REFER) to pain psychology: a modified Delphi approach with multidisciplinary paediatric pain providers at a specialised center in the USA
Authors: Schemer Lea , Harrison Lauren E , Hess Courtney W , Neville Alexandra J , Jehl Nicole , Ma Ryan S L , Glombiewski Julia A , Simons Laura E 
Published: December 2024

BackgroundTo minimise the referral gap to pain psychology, the purpose of this study was to describe clinician-perceived patient suitability for pain psychology referral, develop a referral plan and outline essential elements of a referral conversation via a modified Delphi approach with multidisciplinary paediatric pain providers.MethodsWe employed a three-round modified Delphi approach consulting multidisciplinary paediatric pain providers (n=18) including physicians, psychologists, physical therapists, occupational therapists and nurse practitioners (PT, OT, NP). Based on the responses to an online survey (Round 1), initial statements regarding the pain psychology referral process were developed. These statements were revised in three separate panels (MD panel, PSY panel, PT, OT, NP panel; Round 2). A priori consensus criteria were verified for each statement within and between groups using anonymous responses to a concluding online survey (Round 3).ResultsApproximately one-third of the statements (35%) reached consensus across all panels. For example, paediatric pain providers agreed that referrals should be communicated verbally, along with written materials, and that pain should be explained early from a biopsychosocial perspective. Paediatric pain providers also suggested minimising barriers through a flexible, stepped-care approach that adapts the delivery of pain psychology beyond traditional models. However, most statements reached consensus in only one or two panels (52%), indicating a lack of consensus across disciplines. The data suggest that it was comparatively easier to reach an overall consensus on statements formulating an ideal referral process to pain psychology (50%) than on statements characterising patient suitability (13%).ConclusionsPaediatric pain providers developed an actionable plan for pain psychology referrals. This plan could bridge referral gaps and improve access to pain psychology treatment. Given the low provider consensus on patient suitability, further research is warranted to understand pain psychology referral decision-making, including differing perceptions of patient suitability across disciplines.
Equine-Assisted Services for Veterans with PTSD: a Meta-Analysis
Authors: Cornelius-White Jeffrey H. D. , Joyce Shea E. , Taylor Molly 
Published: December 2024

Abtract
Equine-assisted psychotherapy and therapeutic riding for veterans with posttraumatic stress disorder (PTSD) has been increasingly studied but not meta-analyzed. We identified 2,609 records from database, backward (i.e., reference), and forward (i.e., citation) searches to identify 18 studies addressing effectiveness. The studies were published from 2013–2021 with sample sizes ranging from 5–85 and quality ratings medium – high. Equine-assisted services show large significant effects for change during treatment (n = 14, d = 1.156), follow-up (n = 6, d = 0.994), and compared to waitlist control (n = 1, d = 0.842), and medium effects compared to treatment-as-usual (n = 3, d = 0.465). Examination of these four types of evidence suggests promise for the use of equine-assisted services with veterans for reduction of PTSD symptomatology and a need for more controlled studies, particularly in relation to other specialized treatments also assessed as effective in treating PTSD in veterans.
Dorobek naukowy i organizacyjny Profesor Ireny Kwileckiej
Authors: Lewaszkiewicz Tadeusz 
Published: December 2024

Academic and Organisational Achievements of Professor Irena Kwilecka
Professor Irena Kwilecka focused on Old Polish lexicography and Polish translations of the Bible against the background of Slavic and other European languages. She organised research on the lexicographic works of Bartholomeus de Bydgostia and co-authored a philological edition of his dictionary (Słownik Bartłomieja z Bydgoszczy. Wersja polsko-łacińska, vol. 1–6, Warszawa 1999–2019). She also published four books devoted to partial translations of the Bible by Tomasz Łysy (Thomas the Bald) of Zbrudzewo as well as numerous studies and articles about sixteenth-century Polish translations of the Bible.

Dorobek naukowy i organizacyjny Profesor Ireny Kwileckiej
Profesor Irena Kwilecka zajmowała się leksykografią staropolską i polskimi przekładami Biblii na tle języków słowiańskich i innych języków europejskich. Organizowała badania nad dorobkiem leksykograficznym Bartłomieja z Bydgoszczy i jest współautorką filologicznego wydania jego słownika (Słownik Bartłomieja z Bydgoszczy. Wersja polsko-łacińska, t. 1–6, Warszawa 1999–2019). Opublikowała również cztery książki poświęcone częściowym tłumaczeniom Biblii autorstwa Tomasza Łysego ze Zbrudzewa oraz liczne opracowania i artykuły na temat szesnastowiecznych polskich przekładów biblijnych.
Два малавядомыя лацінаграфічныя тэксты з рукапісу XVIII ст.: спроба моўнай праекцыі на дыялектны ландшафт усходняй часткі Рэчы Паспалітай
Authors: Шклярык [Shkliaryk] Вадзім [Vadzim] 
Published: December 2024

Two Little-Known Texts Written in the Latin Alphabet in an Eighteenth-Century Manuscript: An Attempt at Locating Them in the Dialectal Landscape of the Eastern Part of the Polish-Lithuanian Commonwealth
The article analyses a number of linguistic features of two little-known texts in the Latin alphabet under the conventional titles Krasnaia u Pani Uroda and Myleyka Swoho podkała, which are contained in an eighteenth-century manuscript from the collection of the Warsaw University Library. In one of his monographs, the Belarusian researcher Adam Malʹdzis characterised these texts as Belarusian, but in a description of the manuscript in a Polish reference book they appear as ruskie ‘Ruthenian’. The analysis of phonetic, grammatical and lexical features has shown that the texts under study could have been created in the south-western part of modern Belarus. However, it cannot be excluded that they originated in the north-west of modern Ukraine or in the neighbouring regions of Poland. This allows us to argue that the analysed texts were created in one of the territorial varieties of the language of the East Slavic population of the Polish-Lithuanian Commonwealth.

Dwa mało znane teksty pisane alfabetem łacińskim w XVIII-wiecznym rękopisie: próba ich językowego przyporządkowania do dialektalnego krajobrazu wschodniej części Rzeczypospolitej Obojga Narodów
W artykule przeanalizowano szereg cech językowych dwóch mało znanych, zapisanych alfabetem łacińskim tekstów pod umownymi tytułami Krasnaia u Pani Uroda i Myleyka Swoho podkała, które znajdują się w osiemnastowiecznym rękopisie ze zbiorów Biblioteki Uniwersyteckiej w Warszawie. W jednej ze swoich monografii białoruski badacz Adam Maldzis scharakteryzował te teksty jako białoruskie, ale w opisie rękopisu w jednym z polskich przewodników figurują one jako ruskie. Analiza cech fonetycznych, gramatycznych i leksykalnych wykazała, że teksty te rzeczywiście mogły powstać w południowo-zachodniej części współczesnej Białorusi, nie można jednak wykluczyć, że pochodziły z północno-zachodniej części współczesnej Ukrainy lub z sąsiednich regionów Polski. Pozwala to twierdzić, że analizowane teksty powstały w jednej z odmian terytorialnych języka ludności wschodniosłowiańskiej Rzeczypospolitej Obojga Narodów.
Między teologią a literaturą. „Locus theologicus” i jego rola w twórczości Klemensa Aleksandryjskiego na przykładzie „Wychowawcy”
Authors: Szczot Monika 
Published: December 2024

Between Theology and Literature: The Locus Theologicus and Its Role in the Worksof Clement of Alexandria on the Example of the Paedagogus
This article is an attempt to describe one of the works of Clement of Alexandria (c. 150 – c. 212 AD) in the context of the role played in it by references to other literary works. Clement’s Paedagogus has a complex and hybrid structure, built on numerous quotations and allusions from Christian and pagan works. An analysis of the role of the Bible and classical literature as locus theologicus not only demonstrates the formal and genological complexity of Clement’s manual of moral theology, but also reveals its aesthetic, rhetoricaland theological aims.

Między teologią a literaturą. Locus theologicus i jego rola w twórczości Klemensa Aleksandryjskiego na przykładzie Wychowawcy
Głównym celem artykułu jest próba opisania jednego z utworów Klemensa Aleksandryjskiego (ok. 150 – ok. 212) w kontekście roli, jaką odgrywają w nim odwołania do innych dzieł literackich. Wychowawca Klemensa ma skomplikowaną i hybrydyczną strukturę budowaną na bazie licznych cytatów i aluzji pochodzących z dzieł chrześcijańskich i pogańskich. Analiza roli Pisma Świętego i literatury klasycznej jako „miejsca teologicznego” nie tylko pokazuje formalną i genologiczną złożoność podręcznika teologii moralnej Klemensa, lecz także ujawnia jego estetyczne, retoryczne i teologiczne cele.
Lessons Learned from Evaluating the Climate Change Risk on a Company’s Supply Chain
Authors: Gu Peng , Beck Jacklynn K. , Ding Ruixuan , Quiring Steven M. 
Published: December 2024

Abstract
Every economic sector in the United States is directly or indirectly impacted by weather and climate events. Although the assessment of climate change risk is not a novel concept, the majority of such assessments for individual companies are not published in the peer-reviewed literature. This makes it difficult to evaluate the robustness of these analyses and to determine best practices for effectively evaluating climate change risk at the company level. Here, we outline how we collaborated with a Fortune 500 company to assess the physical risks of climate change to their supply chain. Utilizing state-of-the-art climate models, we provide a template for developing climate change report cards and climate risk maps for all of suppliers, as well as the transportation routes between them. The purpose of these evaluations is to communicate risk to local facility managers and company leadership. By sharing our experiences, we hope that climate scientists may gain insights into quantifying and communicating climate risk to the private sector, potentially assisting them in making more informed climate adaptation decisions.
Where Is the Function Allocation Boundary? The Effect of Degree of Automation on Attention Allocation and Human Performance Under Different Reliabilities
Authors: Wang Shuo , Liu Yu , Wang Xuan , Liu Zechen , You Xuqun , Li Yuan 
Published: December 2024

Objective This study investigated the effect of reliability on the function allocation (FA) boundary by examining the interaction effect of degree of automation (DOA) and reliability on routine performance, failure performance, and attention allocation. Background According to the lumberjack effect, an increase in DOA will typically improve routine performance, while failure performance may remain undeteriorated until a specific, high DOA threshold is reached. This threshold can be regarded as the FA boundary. Considering that both DOA and reliability can influence failure performance through attention allocation, it is crucial to investigate how reliability affects the FA boundary. Method Participants performed three MATB tasks, one of which, the system monitoring task, was supported by four types of automation: information acquisition (IAc), information analysis (IAn), action selection (AS), and action implementation (AI). From IAc to AI, the DOA incrementally increased. Additionally, automation reliability was set to three levels, namely, 87.50%, 68.75%, and 56.25%. Results For routine performance, participants assisted by AS reacted more rapidly to gauge malfunctions than those supported by IAc or IAn. For failure performance, participants aided by AI corrected gauge malfunctions less frequently than other participants. Correspondingly, participants supported by AI exhibited fewer fixation counts on the system monitoring task than did others. Conclusion It appears that the FA boundary lies between AS and AI. However, there is insufficient evidence to support the effect of reliability on the FA boundary. Application These findings can provide useful insights for improving the design of automated systems in complex working environments.
Unfractionated heparin monitoring by anti-factor Xa versus activated partial thromboplastin time strategies during venoarterial extracorporeal life support
Authors: Feng Iris , Powley Tanner R. , Yang Christine G. , Kurlansky Paul A. , Sutherland Lauren D. , Hastie Jonathan M. , Kaku Yuji , Fried Justin A. , Takeda Koji 
Published: December 2024

Introduction No clear guidelines exist for unfractionated heparin (UFH) monitoring in adult patients on veno-arterial extracorporeal life support (VA-ECLS) for refractory cardiogenic shock. In this study, we sought to compare outcomes between anti-factor Xa (FXa) and activated partial thromboplastin time (aPTT) strategies for UFH monitoring during VA-ECLS. Methods This is a single-center, retrospective review of VA-ECLS patients who received UFH in the cardiothoracic intensive care unit between July 2019 and November 2023. Standard protocol for UFH titration was aPTT goal of 45-60 sec ( n = 52) before September 2021, then transitioned to FXa goal of 0.1-0.2 U/mL ( n = 50) thereafter. Inverse probability of treatment weighting was used to balance baseline differences between cohorts. Results In adjusted analyses, 89.3% of FXa patients and 76.0% of aPTT patients achieved goal range for their respective assay. Total UFH duration (4.0 vs 4.0 days, p = .239) and maximum weight-adjusted UFH dose (9.3 vs 9.4 U/hr/kg, p = .823) remained comparable between adjusted FXa and aPTT cohorts. Moreover, in-hospital mortality (50.3% vs 33.9%, p = .133), major bleeding events (20.6% vs 11.2%, p = .292), and thromboembolic events (30.1% vs 30.1%, p = .998) were not significantly different. Extracorporeal circuit thrombosis and cannula site bleeding were the most frequent events in both groups. Multivariate logistic regression found the FXa strategy was not a significant risk factor for the composite outcome of major bleeding or thromboembolism (OR [95% CI]: 1.539 [0.575, 4.116], p = .393). Conclusions In adult VA-ECLS patients at our institution, bleeding and thromboembolic complications occurred at a similar rate regardless of which UFH monitoring strategy was utilized. Further studies in larger and more institutionally diverse cohorts are warranted.
Changes in Risk Tolerance for Ovarian Cancer Prevention Strategies during the COVID-19 Pandemic: Results of a Discrete Choice Experiment
Authors: Egleston Brian L. , Daly Mary B. , Lew Kaitlyn , Bealin Lisa , Husband Alexander D. , Stopfer Jill E. , Przybysz Pawel , Tchuvatkina Olga , Wong Yu-Ning , Garber Judy E. , Rebbeck Timothy R. 
Published: December 2024

Background Prior to COVID-19, little was known about how risks associated with such a pandemic would compete with and influence patient decision making regarding cancer risk reducing medical decision making. We investigated how the pandemic affected preferences for medical risk-reducing strategies among women at elevated risk of breast or ovarian cancer. Methods We conducted a discrete choice experiment. Women about to undergo genetic testing and counseling at 2 medical centers participated. Enrollment occurred between 2019 and 2022, allowing us to investigate changes in preferences from before the pandemic to after the pandemic. Women chose from permuted scenarios that specified type of surgery, age of menopause, quality of menopausal symptoms, and risk of ovarian cancer, heart disease, or osteoporosis. Results A total of 355 women, with a median age of 36 y, participated. In 2019, women were less likely to choose prevention scenarios with higher ovarian cancer risk (odds ratio [OR] = 0.42 per 10-point increase in risk, 95% confidence interval [CI] 0.22–0.61). In June 2020, the effect of higher ovarian cancer risk scenarios on choice was attenuated (OR = 0.86, 95% CI 0.68–1.04), with the effect becoming more salient again by July 2021 (OR = 0.59, 95% CI 0.52–0.67) ( P = 0.039 for test of temporal interaction). No other attribute demonstrated a temporal trend. Conclusion The risks associated with the COVID-19 pandemic may have attenuated the impact of risk of ovarian cancer on choice of risk-reducing prevention strategies for ovarian cancer. The maximum attenuation occurred at the beginning of the pandemic when access to risk-reducing surgery was most restricted. Our findings highlight how individuals evaluate competing health risks and adjust their uptake of cancer prevention strategies when faced with a future pandemic or similar global crisis. Highlights In this discrete choice experiment, women were much less likely to choose prevention scenarios that had higher ovarian cancer risk prior to the COVID-19 pandemic than after the pandemic. The attenuation of preferences may have persisted through 2022. COVID-19 may have altered the relative importance of factors that motivate women to undergo risk-reducing surgeries.
Assessing Coastal Residents Health Literacy (HL) and eHealth Literacy (eHL): Implications for Health Governance
Authors: Krishna Vijay , Pai Rajesh R. , Alathur Sreejith 
Published: December 2024

Purpose: This study aims to analyse the medical and non-medical respondents’ health literacy (HL) and eHealth literacy (eHL) across coastal Karnataka with a goal of improving health governance. Methodology: This research uses pieces of literature published on HL and eHL and sociodemographic factors to roll out a questionnaire survey for respondents from Karnataka, India. The primary study used the independent T-test to distinguish the 260 participants and Spearman’s correlation to determine HL–eHL association. Findings: Independent T-tests showed that medical respondents had a significant higher health literacy in only one scale and a higher mean score as well. The sociodemographic tests revealed that non-medical respondents showed differences based on gender, prescription use and chronic illness. Using Spearman’s correlation, HL and eHL were found to have a positive but weak correlation. Practical Implications: The participants’ varied eHL scores, coupled with their high HL scores, underscored a significant inconsistency in the economic strategies and the health governance in coastal regions. Theoretical Implications: Sustainable development framework followed in this study provides direct implications for multifaceted theories of UN Sustainable Development Goal 3: good health and well-being, Goal 4: quality education, Goal 5: gender equality, Goal 11: sustainable cities and communities and Goal 17: partnerships for the goals. Research Limitations: The study only covers Karnataka’s coastal region, which may differ from other regions in India’s coastal belt. However, the interoperability challenges identified through the differing HL and eHL parameters have broader implications. Originality/Value: Previous research found fewer sociodemographic differences in coastal HL and eHL proficiency. The relationship between HL and eHL on India’s coasts has rarely been studied.
A method for the quantitative evaluation of rail corrugation from the vertical acceleration of the axle-box
Authors: Niu Liubin , Zu Honglin , Xu Xiaodi 
Published: December 2024

Corrugation has attracted increasing attention in railways due to its destructive nature, and axle-box acceleration can provide an effective method of detecting corrugation. However, there is a lack of direct relationship between axle-box acceleration and unacceptable levels of corrugation. Based on the excitation characteristics of corrugation, this study proposes a method to quantitatively evaluate corrugation via axle-box vertical acceleration (ABVA). First, a 3D wheel-rail dynamics model was established by using parameters from China’s high-speed railway, the transfer characteristics of the wheel-rail system were investigated by steady-state response analysis, and the influence of corrugation wavelength in the range of 40 to 300 mm on ABVA was revealed; Second, ABVA excited by corrugation with grinding limit was numerically simulated at a speed of 300 km/h, the map relationship between corrugation and ABVA was obtained, and then influences of natural frequency and contact behavior of wheel-rail system on the map relationship were discussed, a method based on the intervention value was introduced to quantify the degree of corrugation to be ground. Finally, field measurements in high-speed railways were carried out to verify the feasibility of the method, the results showed that the hit rate between the intervention value and the actual scenarios of corrugations was 90.0%, indicating that the proposed method has a good performance in quantitatively evaluating corrugations. This work can provide a scientific reference for decision-makings on whether or not the corrugation is severe enough to be ground.