bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flower‐like Nitrogen‐co‐doped MoS2@RGO Composites with Excellent Stability for Supercapacitors
Authors: Li Min , Addad Ahmed , Zhang Yuan , Barras Alexandre , Roussel Pascal , Amin Mohammed A. , Szunerits Sabine , Boukherroub Rabah 
Published: August 2021

AbstractNitrogen‐co‐doped MoS2@rGO composites (named hereafter N‐MoS2@N‐RGO) are prepared by the hydrothermal method using dicyandiamide or hydrazine monohydrate as the nitrogen source. N‐MoS2@rGO is obtained by the hydrothermal reaction of thioacetamide, ammonium molybdate and GO precursors in the presence of dicyandiamide, while N‐MoS2@N‐RGO is synthesized using the same precursors in the presence of hydrazine monohydrate as the nitrogen source. On the one hand, N‐MoS2@RGO displays excellent performance and good capacitance value of 335 F/g acquired at 0.5A/g and improved stability (∼94% of the original capacitance is preserved after 5000 cycles). On the other hand, compared with N‐MoS2@RGO, N‐MoS2@N‐RGO possesses a slightly higher capacitance of 340 F/g recorded at 0.5A/g and better cycling stability (∼98% of its original value after 5000 cycles). Taken together, the results of this investigation clearly indicate that the fabricated composites have application prospect in energy storage devices.
Surface Chemistry Impact on the Light Absorption by Colloidal Quantum Dots
Authors: Giansante Carlo 
Published: August 2021

AbstractAt the size scale at which quantum confinement effects arise in inorganic semiconductors, the materials’ surface‐to‐volume ratio is intrinsically high. This consideration sets surface chemistry as a powerful tool to exert further control on the electronic structure of the inorganic semiconductors. Among the materials that experience the quantum confinement regime, those prepared via colloidal synthetic procedures (the colloidal quantum dots – and wires and wells, too –) are prone to undergo surface reactions in the solution phase and thus represent an ideal framework to study the ensemble impact of surface chemistry on the materials’ electronic structure. It is here discussed such an impact at the ground state by using the absorption spectrum of the colloidal quantum dots as a descriptor. The experiments show that the chemical species (the ligands) at the colloidal quantum dot surface induce changes to the optical band gap, the absorption coefficient at all wavelengths, and the ionization potential. These evidences point to a description of the colloidal quantum dot (the ligand/core adduct) as an indecomposable species, in which the orbitals localized on the ligands and the core mix in each other's electric field. This description goes beyond conventional models that conceive the ligands on the basis of pure electrostatic arguments (i. e., either as a dielectric shell or as electric dipoles) or as a mere potential energy barrier at the core boundaries.
The basophil activation test differentiates between patients with wheat‐dependent exercise‐induced anaphylaxis and control subjects using gluten and isolated gluten protein types
Authors: Gabler Angelika Miriam , Gebhard Julia , Eberlein Bernadette , Biedermann Tilo , Scherf Katharina Anne , Brockow Knut 
Published: August 2021

AbstractBackgroundOral food challenge using gluten and cofactors is the gold standard to diagnose wheat‐dependent exercise‐induced anaphylaxis (WDEIA), but this procedure puts patients at risk of an anaphylactic reaction. Specific IgE to ω5‐gliadins as major allergens and skin prick tests to wheat may yield negative results. Thus, we designed a proof‐of‐principle study to investigate the utility of the basophil activation test (BAT) for WDEIA diagnosis.MethodsDifferent gluten protein types (GPT; α‐, γ‐, ω1,2‐ and ω5‐gliadins, high‐molecular‐weight glutenin subunits [HMW‐GS] and low‐molecular‐weight glutenin subunits [LMW‐GS]) and gluten were used in different concentrations to measure basophil activation in 12 challenge‐confirmed WDEIA patients and 10 control subjects. The results were compared to routine allergy diagnostics. Parameters analyzed include the percentage of CD63+ basophils, the ratio of %CD63+ basophils induced by GPT/gluten to %CD63+ basophils induced by anti‐FcεRI antibody, area under the dose‐response curve and test sensitivity and specificity.ResultsGPT and gluten induced strong basophil activation for %CD63+ basophils and for %CD63+/anti‐FcɛRI ratio in a dose‐dependent manner in patients, but not in controls (p < 0.001, respectively). BAT performance differed from acceptable (0.73 for LMW‐GS) to excellent (0.91 for ω5‐gliadins) depending on the specific GPT as evaluated by the area under the receiver operating characteristic curve. Patients showed individual sensitization profiles. After determination of the best cut‐off points, ω5‐gliadins and HMW‐GS showed the best discrimination between patients and controls with a sensitivity/specificity of 100/70 and 75/100, respectively.ConclusionThis study shows the alternative role of BAT in better defining WDEIA and the causative wheat allergens. The best BAT parameters to distinguish WDEIA patients from controls were %CD63+ basophil values for ω5‐gliadins and HMW‐GS.
Identification and Classification of Technical Lignins by means of Principle Component Analysis and k‐Nearest Neighbor Algorithm
Authors: Fink Friedrich , Emmerling Franziska , Falkenhagen Jana 
Published: August 2021

AbstractInvited for this month's cover is the group of Dr. Jana Falkenhagen at the Bundesanstalt für Materialforschung und ‐prüfung in Berlin (Germany). The cover picture shows an artistic map like those found in many novels. The rivers serve as natural borders to separate different types of plants, such as softwood, hardwood, straw and grass. The idea for this abstract illustration comes from the core illustration of the work on which it is based. Read the full text of their Full Paper at 10.1002/cmtd.202100028.
Pancreas cancer and BRCA: A critical subset of patients with improving therapeutic outcomes
Authors: Momtaz Parisa , O’Connor Catherine A. , Chou Joanne F. , Capanu Marinela , Park Wungki , Bandlamudi Chaitanya , Berger Michael F. , Kelsen David P. , Suehnholz Sarah P. , Chakravarty Debyani , Yu Kenneth H. , Varghese Anna M. , Zervoudakis Alice , Li Jia , Ku Geoffrey Y. , Park Jennifer S. , Shcherba Marina , Harding James J. , Goldberg Zoe , Abou‐Alfa Ghassan K. , Salo‐Mullen Erin E. , Stadler Zsofia K. , Iacobuzio‐Donahue Christine A. , O’Reilly Eileen M. 
Published: August 2021

BackgroundPatients with germline/somatic BRCA1/BRCA2 mutations (g/sBRCA1/2) comprise a distinct biologic subgroup of pancreas ductal adenocarcinoma (PDAC).MethodsInstitutional databases were queried to identify patients who had PDAC with g/sBRCA1/2. Demographics, clinicopathologic details, genomic data (annotation sBRCA1/2 according to a precision oncology knowledge base for somatic mutations), zygosity, and outcomes were abstracted. Overall survival (OS) was estimated using the Kaplan‐Meier method.ResultsIn total, 136 patients with g/sBRCA1/2 were identified between January 2011 and June 2020. Germline BRCA1/2 (gBRCA1/2) mutation was identified in 116 patients (85%). Oncogenic somatic BRCA1/2 (sBRCA1/2) mutation was present in 20 patients (15%). Seventy‐seven patients had biallelic BRCA1/2 mutations (83%), and 16 (17%) had heterozygous mutations. Sixty‐five patients with stage IV disease received frontline platinum therapy, and 52 (80%) had a partial response. The median OS for entire cohort was 27.6 months (95% CI, 24.9‐34.5 months), and the median OS for patients who had stage IV disease was 23 months (95% CI, 19‐26 months). Seventy‐one patients received a poly(adenosine diphosphate ribose) polymerase (PARP) inhibitor (PARPi), and 52 received PARPi monotherapy. For maintenance PARPi, 10 patients (36%) had a partial response, 12 (43%) had stable disease, and 6 (21%) had progression of disease as their best response. Six patients (21%) received maintenance PARPi for >2 years. For those with stage IV disease who received frontline platinum, the median OS was 26 months (95% CI, 20‐52 months) for biallelic patients (n = 39) and 8.66 months (95% CI, 6.2 months to not reached) for heterozygous patients (n = 4). The median OS for those who received PARPi therapy was 26.5 months (95% CI, 24‐53 months) for biallelic patients (n = 25) and 8.66 months (95% CI, 7.23 months to not reached) for heterozygous patients (n = 2).Conclusionsg/sBRCA1/2 mutations did not appear to have different actionable utility. Platinum and PARPi therapies offer therapeutic benefit, and very durable outcomes are observed in a subset of patients who have g/sBRCA1/2 mutations with biallelic status.
Adolescent and young adult enrollment to a National Cancer Institute–sponsored National Clinical Trials Network Research Group over 25 years
Authors: Unger Joseph M. , Beauchemin Melissa , Hershman Dawn L. 
Published: August 2021

BackgroundAdolescent and young adult (AYA) patients with cancer have not seen the same improvements in survival as younger (pediatric) patients and older patients (adults 40 years old or older). This may be related to their lower participation in clinical trials.MethodsThis study examined AYA patient accrual to SWOG Cancer Research Network phase 1 to 3 clinical treatment trials for 29 cancers over 25 years (January 1996 to December 2020). Trial enrollments for AYA patients (15‐39 years old) were compared with trial enrollments for older patients (40 years old or older) in SWOG and with US AYA cancer population rates derived from US Census and National Cancer Institute/Surveillance, Epidemiology, and End Results data.ResultsIn total, 84,219 patients were enrolled in SWOG treatment trials, including 7109 AYA patients (8.4%); in contrast, AYAs constituted 3.8% of the US cancer population. By histology, the highest proportions of AYA patients were in trials for Hodgkin disease (825 of 1220; 67.6%) and acute lymphocytic leukemia (350 of 678; 51.6%), whereas breast cancer trials had the greatest number of AYA patients (3032 of 32,693; 9.3%). SWOG AYA patients were more often female (68.8% vs 58.7%; P < .001), Black (10.1% vs 8.2%; P < .001), and Hispanic (10.6% vs 5.6%; P < .001) than SWOG patients who were 40 years old or older, and they were more often female (68.8% vs 65.1%; P < .001) but less often Black (10.1% vs 11.8%; P < .001) or Hispanic (10.6% vs 12.8%; P < .001) than AYA patients in the US cancer population.ConclusionsAYA patients with cancer were well represented in SWOG clinical trials in comparison with US cancer population patients with the same cancers. The SWOG AYA population was more racially/ethnically diverse than older SWOG patients, although it was less diverse than the US AYA cancer population.Lay Summary

Adolescent and young adult (AYA) patients with cancer (aged 15‐39 years) have not seen the same improvements in survival as younger (pediatric) patients and older patients (adults 40 years old or older). This may be related to their lower participation in clinical trials.

This study evaluated the extent to which AYA patients were enrolled in a large, National Cancer Institute–sponsored network group over 25 years (1996‐2020).

Overall, 8.4% of the enrolled patients (7109 of 84,219) were AYAs; this was twice the corresponding rate of 3.8% in the US cancer population.

AYA patients were also more racially/ethnically diverse than older trial patients, although they were less racially/ethnically diverse than the US AYA cancer population.
The RNA‐binding protein and stress granule component ATAXIN‐2 is expressed in mouse and human tissues associated with glaucoma pathogenesis
Authors: Sundberg Chad A. , Lakk Monika , Paul Sharan , P. Figueroa Karla , Scoles Daniel R. , Pulst Stefan M. , Križaj David 
Published: August 2021

AbstractPolyglutamine repeat expansions in the Ataxin‐2 (ATXN2) gene were first implicated in Spinocerebellar Ataxia Type 2, a disease associated with degeneration of motor neurons and Purkinje cells. Recent studies linked single nucleotide polymorphisms in the gene to elevated intraocular pressure in primary open angle glaucoma (POAG); yet, the localization of ATXN2 across glaucoma‐relevant tissues of the vertebrate eye has not been thoroughly examined. This study characterizes ATXN2 expression in the mouse and human retina, and anterior eye, using an antibody validated in ATXN2−/− retinas. ATXN2‐ir was localized to cytosolic sub compartments in retinal ganglion cell (RGC) somata and proximal dendrites in addition to GABAergic, glycinergic, and cholinergic amacrine cells in the inner plexiform layer (IPL) and displaced amacrine cells. Human, but not mouse retinas showed modest immunolabeling of bipolar cells. ATXN2 immunofluorescence was prominent in the trabecular meshwork and pigmented and nonpigmented cells of the ciliary body, with analyses of primary human trabecular meshwork cells confirming the finding. The expression of ATXN2 in key POAG‐relevant ocular tissues supports the potential role in autophagy and stress granule formation in response to ocular hypertension.
Green ambidexterity and environmental performance: The role of green human resources
Authors: Úbeda‐García Mercedes , Marco‐Lajara Bartolome , Zaragoza‐Sáez Patrocinio C. , Manresa‐Marhuenda Encarnación , Poveda‐Pareja Esther 
Published: August 2021

AbstractRecent literature in the domain of environmental management suggests that employees' behavior is vital to enhance environmental performance. Despite this, little effort has been made to study how human resource management is linked with the environmental performance. Even less attention has been given to a joint consideration of green innovation and green human resources management and their contribution to environmental performance. The purpose of the current study is to investigate the interrelationship between green high performance work system (GPWS) and environmental performance through the mediation of green ambidexterity. A variance‐based structural equation modeling (partial least squares) was applied to a sample of Spanish hotel firms. The results indicate that GHPWS facilitate the development of green ambidexterity, and that this variable contributes to improved environmental performance. The results of this study make several contributions to the GHRM and green ambidexterity literature, as well as practical contributions for managers.
R&D as bridge to sustainable development? Case of Czech Republic and Slovenia
Authors: Hojnik Jana , Prokop Viktor , Stejskal Jan 
Published: August 2021

AbstractPrior studies revealed that government is key factor influencing firms' decisions about the implementation of environmental innovations and pursuit of sustainable development as well as shaping their environmental orientation. However, the role of firms' R&D within these processes remains unclear. This paper explores the relationship between firms' environmental regulation, R&D, environmental orientation, and environmental outputs to better understand the relationships and dynamics among them. We used the World Bank Enterprise Survey 2019 data on 737 firms from the Czech Republic and Slovenia and employed structural equation modeling. The results indicate that environmental orientation positively influences R&D and environmental outputs. Moreover, environmental regulations spur firms' environmental orientation as well as environmental outputs. On the other hand, the findings reveal that R&D is neither a key factor nor plays a key role as a mediator of environmental regulations and environmental orientation affecting environmental outputs based on the sample of selected countries pertaining to Central and Eastern Europe.
Efficient data uncertainty management for health industrial internet of things using machine learning
Authors: Haseeb Khalid , Saba Tanzila , Rehman Amjad , Ahmed Imran , Lloret Jaime 
Published: August 2021

SummaryIn modern technologies, the industrial internet of things (IIoT) has gained rapid growth in the fields of medical, transportation, and engineering. It consists of a self‐governing configuration and cooperated with sensors to collect, process, and analyze the processes of a real‐time system. In the medical system, healthcare IIoT (HIIoT) provides analytics of a huge amount of data and offers low‐cost storage systems with the collaboration of cloud systems for the monitoring of patient information. However, it faces certain connectivity, nodes failure, and rapid data delivery challenges in the development of e‐health systems. Therefore, to address such concerns, this paper presents an efficient data uncertainty management model for HIIoT using machine learning (EDM‐ML) with declining nodes prone and data irregularity. Its aim is to increase the efficacy for the collection and processing of real‐time data along with smart functionality against anonymous nodes. It developed an algorithm for improving the health services against disruption of network status and overheads. Also, the multi‐objective function decreases the uncertainty in the management of medical data. Furthermore, it expects the routing decisions using a machine learning‐based algorithm and increases the uniformity in health operations by balancing the network resources and trust distribution. Finally, it deals with a security algorithm and established control methods to protect the distributed data in the exposed health industry. Extensive simulations are performed, and their results reveal the significant performance of the proposed model in the context of uncertainty and intelligence than benchmark algorithms.
New topical therapies for psoriasis
Authors: Buechler Connor R. , Veenstra Jesse , Stein Gold Linda 
Published: August 2021

AbstractBackgroundPsoriasis is a debilitating autoimmune condition that causes red scaly plaques of the skin with potential to produce systemic inflammation affecting multiple organ systems. While the majority of patients can be managed with topical therapy, no one topical medication is right for everyone, and the therapeutic armamentarium continues to expand with improved delivery vehicles and new active ingredients. This review will discuss recently approved and upcoming topical medications for psoriasis.Recent advancesThe past several years have seen the advent of novel lotion and cream vehicles as well as new options for spray or foam application, fixed‐dose combined medications, and nonsteroidal options. New corticosteroid topical monotherapies in improved vehicles include halobetasol propionate (HP) 0.05% foam, HP 0.01% lotion, clobetasol propionate 0.025% cream, and betamethasone dipropionate (BD) 0.05% spray. Fixed‐dose combination topical therapies include calcipotriene 0.005% plus BD 0.064% (Cal‐BD) foam, Cal‐BD cream, and HP 0.01% plus tazarotene 0.045% lotion. Numerous nonsteroidal offerings are poised to enter the market, most notably tapinarof 1% cream, roflumilast 0.3% cream, and roflumilast 0.3% foam.SummaryRecent advancements in both delivery vehicles and medications available for topical treatment of psoriasis have the potential to allow better control of disease and increase treatment satisfaction among patients.
Method for quick DNA barcode reference library construction
Authors: Liu Yanlei , Xu Chao , Sun Yuzhe , Chen Xun , Dong Wenpan , Yang Xueying , Zhou Shiliang 
Published: August 2021

AbstractDNA barcoding has become one of the most important techniques in plant species identification. Successful application of this technology is dependent on the availability of reference database of high species coverage. Unfortunately, there are experimental and data processing challenges to construct such a library within a short time. Here, we present our solutions to these challenges. We sequenced six conventional DNA barcode fragments (ITS1, ITS2, matK1, matK2, rbcL1, and rbcL2) of 380 flowering plants on next‐generation sequencing (NGS) platforms (Illumina Hiseq 2500 and Ion Torrent S5) and the Sanger sequencing platform. After comparing the sequencing depths, read lengths, base qualities, and base accuracies, we conclude that Illumina Hiseq2500 PE250 run is suitable for conventional DNA barcoding. We developed a new “Cotu” method to create consensus sequences from NGS reads for longer output sequences and more reliable bases than the other three methods. Step‐by‐step instructions to our method are provided. By using high‐throughput machines (PCR and NGS), labeling PCR, and the Cotu method, it is possible to significantly reduce the cost and labor investments for DNA barcoding. A regional or even global DNA barcoding reference library with high species coverage is likely to be constructed in a few years.
Undergraduate student conceptions of climate change impacts on animals
Authors: Holt Emily A. , Heim Ashley B. , Sexton Julie , Hinerman Krystal 
Published: August 2021

AbstractClimate change is a critical environmental issue and is a recommended core concept in the Ecological Society of America’s 4‐Dimensional Ecology Education framework. Limited work describes K‐12 students’ conceptions of the biotic impacts of climate change, yet research is lacking to explore undergraduate students’ conceptions on this topic. Our goal was to describe undergraduate student conceptions of the biotic outcomes of climate change, and characterize how these student conceptions of animal responses to climate change align with accepted scientific ideas. We used an interpretive qualitative research design and interviewed 13 undergraduate students who were enrolled in either an introductory biology or general ecology course. Through two independent codings of the same dataset, we separately addressed each of our research goals. Prior to this study, we identified three general biotic outcomes from climate change, which were confirmed by outside experts: changes to an animal’s Growth and Survival, their Reproduction, or their Distribution. Our student interviewees as a whole mentioned all three of these outcomes, and most individuals mentioned all three in their responses. Additionally, we found that most student ideas were aligned with Scientific conceptions, while a third of student ideas contained some scientific conceptions but were incomplete. Only a small percent of conceptions voiced in our sample were identified as alternative conceptions that did not align with accepted scientific ideas. These findings are important for educators who teach climate change, as they suggest that undergraduate students come to our classes with productive resources; however, our findings also identify concepts where students may struggle or enter classrooms with a more incomplete understanding.
Electrochemiluminescence Enhanced by the Synergetic Effect of Porphyrin and Multi‐walled Carbon Nanotubes for Uric Acid Detection
Authors: Zhang Liying , Zhao Chuanrui , Bai Yujiao , Wang Qian , Ma Pan , Ma Xiaojie , Zhu Peihua 
Published: August 2021

AbstractThe design and exploration of efficient, stable and environmentally compatible organic emitters for an electrochemiluminescence (ECL) sensor is a promising topic. Herein, a novel environmentally‐friendly luminophore, ZnBCBTP@MWCNTs, were fabricated via self‐assembly of porphyrin molecules (ZnBCBTP) onto multi‐walled carbon nanotubes (MWCNTs). The resulting luminophore ZnBCBTP@MWCNTs displayed not only the highly ECL property and but also the good accelerated electron mobility. Then, a label‐free ECL biosensor based ZnBCBTP@MWCNTs was constructed for the ultrasensitive detection of uric acid. Excitingly, this proposed ECL biosensor performed a good linear relationship in the range of 0–300 μM with a low detection limit of 1.4 μM, thus offering another reliable and feasible sensing platform for clinical bioanalysis with good selectivity, stability, and repeatability.