bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Phase I Study of K-001 in Patients with Advanced Pancreatic Ductal Adenocarcinoma
Authors: Cui Jiujie , Yang Haiyan , Liu Jue , Chen Donghui , Hu Jiong , Zhang Haiyan , Wang Yu , Han Ting , Mao Tiebo , Jiao Feng , Biskup Ewelina , Pan Yaotian , Liu Min , Wang Liwei 
Published: April 2021

Abstract
Background:K-001 is an oral antitumor drug made from active ingredients of marine microorganisms. The current study aimed to evaluate safety and antitumor activity of K-001 in patients with advanced pancreatic ductal adenocarcinoma (PDAC).Methods:In this phase I, open-label trial, patients with advanced PDAC were recruited to a dose-escalation study in a standard 3+3 design. K-001 was administered twice daily in 4-week cycles, and dose escalation from 1350mg to 2160mg twice daily was evaluated. Physical examination and laboratory tests were done at screening and then weekly. The safety, dose-limiting toxicity (DLT), and maximum tolerated dose (MTD) of K-001 were assessed, and tumor response was estimated by Response Evaluation Criteria in Solid Tumor (RECIST).Results:Eighteen patients with advanced PDAC were screened, and twelve eligible patients were analyzed in the study. No DLT was observed. Totally, 47 adverse events (AEs) presented, and 14 drug-related AEs were reported in 7 patients, including 8 grade 1 events (57.1%) and 6 grade 2 events (42.9%). There was no grade 3 or 4 drug-related AE. In these 14 drug-related AEs, the most frequent ones were dyspepsia (21.4%), followed by flatulence, constipation, and haemorrhoids bleeding (above 10% of each). Among all 12 patients, 10 patients (83.3%) maintained stable disease (SD), and 2 patients (16.7%) had progressive disease (PD). The objective response rate (ORR) was 0% and the disease control rate (DCR) was 83.3%.Conclusions:K-001 has satisfactory safety and tolerability, as well as meaningful antitumor activity in advanced PDAC patients. Further evaluation of K-001 in phase II/III appears warranted.Trial registration: NCT02720666. Registered 28 Match 2016 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02720666.
Effects of Gold Nanoparticles Combined Human β-defensin 3 on The Alveolar Bone of Experimental Periodontitis
Authors: Zhou Jing , Li Lingjun , Cui Di , Xie Xiaoting , Yang Wenrong , Yan Fuhua 
Published: April 2021

Abstract
Background

Nanomaterials of biomedicine and tissue engineering have been proposed in the treatment of periodontitis recently. This study aimed to investigate the effect of gold nanoparticles (AuNPs) combined human β-defensin 3 (hBD3) on the repair of alveolar bone of experimental periodontitis in rats.
Methods

A model of experimental periodontitis was established by ligating of the maxillary second molars with silk thread in rats, which were treated with or without AuNPs combined hBD3. Micro-focus computerized tomography (micro-CT) scanning, enzyme-linked immunosorbent assay (ELISA) and histological and immunohistochemical staining, including alkaline phosphatase (ALP), osteoprotegerin (OPG) tartrate-resistant acid phosphatase (TRAP) and receptor activator of NF-κB Ligand (RANKL), were used to analyze.
Results

Micro-CT demonstrated that the alveolar bone resorption was significantly reduced after the treatment of AuNPs combined hBD3. Levels of TNF-α and IL-6 decreased markedly compared with the ligation group. HE and Masson staining showed that AuNPs combined hBD3 group had less inflammatory cell infiltration, collagen fibrosis and fracture, but higher calcification in the new bone tissue. Moreover, the administration of AuNPs combined hBD3 increased the expression of ALP and OPG (related to bone formation) expression, while decreased TRAP and RANKL (related to bone resorption) expression.
Conclusions

AuNPs combined hBD3 had a protective effect on the progress of experimental periodontitis in rats, and also played a certain role in promoting osteogenesis.
Source Tracking of Carbapenem-Resistant Enterobacteriaceae Outbreaks in Neonatal Patients Revealed Rivers Contaminated with NDM Genes
Authors: Wang Jianshjeng , Yin Changfu , Lv Yuanpeng , Yang Weiwei , Zhao Peng 
Published: April 2021

Abstract
Background

Carbapenem-resistant Enterobacteriaceae (CRE) prevalence in neonatal patients continues to rise in china. However, very few epidemiological data are available to uncover the underlying mechanisms for the increase. This study aimed to elucidate their transmission modes and explore potential sources.
Methods

The genotypic features of CRE isolates were analyzed by PCR and sequencing. The elucidation of transmission and sources involved in electronic medical record review, environmental cultures, screening cultures, and prospective case-control analysis.
Results

A total of 450 CRE isolates recovered from 369 infant patients were genotypically characterised. Carbapenemase genes NDM-1, KPC-2 and IMP-4 accounted for 86.22% (n = 388), 8.89% (n = 40) and 4.44% (n = 20), respectively. After implementation of intensified control measures, CRE rectal prevalence rates in both the 0–3 days and the 4–28 days age group were decreased from 15.53% (100/644) and 27.37% (52/190) to 11.78% (51/433) and 19.59% (19/97) (P = 0.082 and P = 0.148), respectively. Multivariate analysis showed that gastric lavage (odds ratio [OR]) 3.09, 95% confidence interval [CI] 1.49–6.39) and enema (OR 2.84, 95% CI 1.65–4.91) were independent risk factors for rectal colonisation in the 0–3 days age group, whereas Cephalosporins (OR 2.12, 95% CI 1.14–3.94), gastric lavage (OR 3.44, 95% CI 1.44–8.22) and residence in rural area (OR 2.22, 95% CI 1.19–4.13) were independently associated with rectal colonization in the 4–28 days age group. The strict management of aseptic procedures eventually halted the silent spread. The transmission tracking of neonatal NDM-1 strains outbreaks revealed rivers contaminated with NDM genes.
Conclusions

Continued vigilance for importations should be maintained to reduce CRE threat. Community awareness raising campaigns are urgently needed to reduce CRE threat.
Expression of IL-23 in gilt endometrium and oviduct after insemination with seminal plasma, spermatozoa or semen extender
Authors: Svensson Anna , Jiwakanon Jatesada , Fossum Caroline , Dalin Anne-Marie 
Published: April 2021

Abstract
Objective: Insemination with spermatozoa, seminal plasma and extender, cause a rapid inflammatory response in the pig endometrium, which is characterized by an influx of neutrophils into the uterus. The transient inflammatory response to semen involves cytokine induction. Potential functions for Interleukin-23 (IL-23) in the inflammatory response to different insemination treatments were examined by studying mRNA expression and immunostaining in gilt oviduct and endometrium 35-40 h after insemination. Insemination was performed with seminal plasma (SP), spermatozoa (SPZ) without SP in the extender Beltsville thawing solution (BTS), or BTS alone. In control gilts an insemination catheter was inserted without anything being inseminated. Results: Results showed that IL-23 mRNA was expressed in oviduct and endometrium. There was an approximate 2-4-fold increase in expression of IL-23 mRNA in catheter-only control compared with SPZ, SP and BTS treatment groups. IL-23 immunolabelling was detected in a small number of separate cells as well as in the sub-epithelial connective tissue of the endometrium, the endosalpinx of the isthmus and infundibulum. In conclusion, all fluids used for insemination decreased the expression of IL-23 mRNA in the endometrium compared to catheter-insertion alone, indicating a possible role for IL-23 in the inflammatory response after insemination in gilts.
Improved and promising fecal sludge sanitizing methods: treatment of fecal sludge using resource recovery technologies
Authors: Zewde Abraham Amenay , Li Zifu , Xiaoqin Zhou 
Published: April 2021

AbstractThe global challenges that face sustainable sanitation services in developing countries are the lack of fecal sludge (FS) management; this is due to the rapid urbanization and population growth as it generates enormous quantities of fecal sludge. The extensive use of unimproved sanitation technologies is one of the main reasons for environmental and public health concerns. In dispersed rural areas, isolated slums or in urban areas where a sewerage system is costly, a decentralized wastewater system can be used. Therefore centralized management of decentralized wastewater systems along with proper institutional framework treatment of fecal sludge can be used to enhance the economies of developing countries from resource recovery. The discovery of new ways to inactivate pathogens contained in human waste is key in improving access to sanitation worldwide and reducing the impact of conventional waste management processes on the environment. The entire FS management system should include on-site sanitary treatment methods, collection, and transportation of FS, treatment facilities as well as resource recovery or disposal of the treated end products. This review paper addresses the hygienization of fecal sludge and improved treatment technologies for safe reuse or disposal of the end products and the significant economic revenues attained from the treatments of fecal sludge.
Impacts of irrigation and nitrate fertilization scenarios on groundwater resources quantity and quality of the Almyros Basin, Greece
Authors: Lyra Aikaterini , Loukas Athanasios , Sidiropoulos Pantelis 
Published: April 2021

Abstract
Irrigation and nitrate fertilization scenarios were combined and simulated for crop water irrigation demands and nitrogen applications based on experiments on crop cultivation practices. Two irrigation practices (deficit irrigation and rainfed conditions) were applied to the main crop types of the Almyros Basin, a coastal basin located in Thessaly, Greece. The Almyros groundwater system suffers from progressive water balance deficit, nitrate contamination and seawater intrusion due to groundwater abstractions for agricultural irrigation to cover crop water demands in the dry season. The impacts of the irrigation and nitrate fertilization scenarios on groundwater resources quantity and quality were simulated using an Integrated Modelling System consisting of models of surface hydrology (UTHBAL), groundwater hydrology (MODFLOW), crop growth/nitrate leaching (REPIC), contaminant transport (MT3DMS), and seawater intrusion (SEAWAT), for the historical period of 1991–2018. The results of the scenarios were evaluated with the indicators of Crop Water Productivity (CWP) for crop yields and irrigation water, Partial Factor Productivity (PFP) for Nitrogen Use Efficiency, and Economic Water Productivity (EWP) for the gross profits of the irrigation water.
Amidation modified waste polystyrene foam as an efficient recyclable adsorbent for organic dyes removal
Authors: Pu Yanghao , Xie Zhengfeng , Ye Hao , Shi Wei 
Published: April 2021

Abstract
Modifying environmentally harmful waste polystyrene foam as an efficient recyclable adsorbent for organic dyes is important. Amidation modified polystyrene (PS-SD) was prepared by the Friedel-Crafts reaction and N,N'-dicyclohexylcarbodiimide (DCC) dehydration condensation reaction of waste polystyrene foam. PS-SD had highly efficient removal performance for organic dyes in large volume water sample solutions, and equilibrium was achieved in 0.5 h. The maximum adsorption capacities for Methylene blue (MB) and Congo red (CR) were 881.62 and 1,880.91 mg/g, respectively, at room temperature according to the Langmuir adsorption isotherm (R2 &gt; 0.99). The kinetic data of the two dyes followed pseudo-second-order kinetics. The removal percentage remained high (&gt;85%) after eight filtration-regeneration cycles. Experimental results showed that PS-SD was an excellent adsorbent for water treatment with high recyclability and long life.
Investigation of the Effect of Operating Room Environment and Cesarean
Section Orientation on Physiological Parameters (BP, Heart Rate, Respiration)
in Candidates for Cesarean Section in Shiraz: A Clinical Trial Study
Authors: Eslami Jamshid , Hatami Neda , Amiri Aazadeh , Akbarzadeh Marzieh 
Published: April 2021

Background: :
Changes in physiological parameters in pregnant women are important factors
in mothers who are candidates for cesarean section.

Objective::
The aim of the present study was to investigate the effect of an operating room and cesarean
section orientation on the physiological parameters (BP, heart rate, respiration) of pregnant
women undergoing cesarean section.

Materials and Methods::
This clinical trial study was performed on 80 pregnant women referring
to a cesarean section in hospitals affiliated to Shiraz University of Medical Sciences in 2019. The
samples were randomly divided into two control (n = 40) and intervention groups (n = 40). The intervention
group participated in 4 sessions of training classes. The control group used routine hospital
training. The parameters were measured before and after the intervention in two groups. Data
were analyzed using SPSS software (version 21), independent t-test, and analysis of covariance.

Results:
The mean of post-training blood pressure in the intervention group, i.e., 82.78(7.86), and
the control group, i.e., 84.08 (7.44), was not statistically significant (p < .487). After the intervention,
the mean heart rate in the intervention group, i.e., 82.15 (8.10) and in the control group, i.e.,
83.43 (8.54), was statistically significant (p <0.0001). After the intervention, the mean respiratory
rate in the intervention group was 94.28 (0.96) and in the control group was 75.96 (1.08) (P
<0.0001).

Conclusions:
Although the patient's operating room and cesarean section orientation did not affect
mothers' mean blood pressure, it reduced the mean of their heart rate and respiratory rate. It is important
for medical staff to play an important role in identifying important strategies in managing
the anxiety of pregnant women in order to improve their physiological indicators.
This study was also registered in the Iranian Registry of Clinical Trials (IRCT code:
20130710013940N6).
Effect of Substrate on the Performance of Flexible Energy Storage Devices based on Surface Modified C60– β Ni(OH)2 Nanocomposite
Authors: Sasi Soorya , Sugunan Sunish K. , P. Radhakrishnan Nair , Mathew Suresh 
Published: April 2021

Aim:
Aim of this study is to find the effect of the current collector on the performance of
flexible energy storage devices based on surface modified organic-inorganic composite.

Objective:
As a part of our pursuit to develop flexible supercapacitive electrodes, we recently reported
the fabrication of an electrode from an organic-inorganic composite slurry of surface functionalized
fullerene and nickel hydroxide coated onto a copper sheet substrate using simple doctor
blade method. We reported that the electrodes deliver specific energy and specific power of 661.5
Wh/kg and 8.8 KW/kg, respectively, and a specific capacitance of 675 Fg−1, which showed excellent
cycling stabilities. In an effort to search for various combinatorial combinations of the composite
and the substrate, in lieu of copper, in the present study, we incorporate nickel sheet as the current
collector.

Methods:
The structure and composition of the binder-free, flexible, super capacitive electrodes
were characterized using XRD, TEM, FTIR, XPS, BET, Raman Spectroscopy, and their electrochemical
properties were characterized using cyclic voltammetry, galvanostatic charge-discharge
measurements, chronoamperommetry and impedance spectroscopy.

Result:
The as-prepared films stuck readily onto the substrate without the need for any binder material,
exhibited remarkable flexibility, and were proven to be crack-free when subjected to repeated
bending and twisting. The developed flexible, super capacitive electrodes deliver a specific capacitance
of 296 F g−1, maximum energy density of 82.2 Wh kg−1, and a maximum power density of
1056 W kg−1. The device retains 91.2 % of its capacitance when subjected to 1000 charge-discharge
cycles.

Conclusion:
Our observations indicate that copper is the better choice as the current collector,
which can be ascribed to the better electrical conductivity of copper compared to nickel. We conclude
that the poor electrical conductivity of nickel sheet compared to copper substrate make the
bottleneck for the performance of electrodes made using nickel substrate. To recapitulate, a judicious
choice of a current collector with high electrical conductivity along with a suitable surface
modification strategy to form a composite in an amorphous form that forms smooth slurry are vital
to the fabrication of binder-free, flexible supercapacitive devices.
Evaluating the Effectiveness of NoteAid in a Community Hospital Setting: Randomized Trial of Electronic Health Record Note Comprehension Interventions With Patients
Authors: Lalor John P , Hu Wen , Tran Matthew , Wu Hao , Mazor Kathleen M , Yu Hong 
Published: April 2021

Background
Interventions to define medical jargon have been shown to improve electronic health record (EHR) note comprehension among crowdsourced participants on Amazon Mechanical Turk (AMT). However, AMT participants may not be representative of the general population or patients who are most at-risk for low health literacy.

Objective
In this work, we assessed the efficacy of an intervention (NoteAid) for EHR note comprehension among participants in a community hospital setting.

Methods
Participants were recruited from Lowell General Hospital (LGH), a community hospital in Massachusetts, to take the ComprehENotes test, a web-based test of EHR note comprehension. Participants were randomly assigned to control (n=85) or intervention (n=89) groups to take the test without or with NoteAid, respectively. For comparison, we used a sample of 200 participants recruited from AMT to take the ComprehENotes test (100 in the control group and 100 in the intervention group).

Results
A total of 174 participants were recruited from LGH, and 200 participants were recruited from AMT. Participants in both intervention groups (community hospital and AMT) scored significantly higher than participants in the control groups (P<.001). The average score for the community hospital participants was significantly lower than the average score for the AMT participants (P<.001), consistent with the lower education levels in the community hospital sample. Education level had a significant effect on scores for the community hospital participants (P<.001).

Conclusions
Use of NoteAid was associated with significantly improved EHR note comprehension in both community hospital and AMT samples. Our results demonstrate the generalizability of ComprehENotes as a test of EHR note comprehension and the effectiveness of NoteAid for improving EHR note comprehension.
Результаты тотальной артропластики по поводу прогрессирующей дисплазии тазобедренного сустава
Authors: Kanziuba A.I. , Yurchenko D.A. 
Published: April 2021

Актуальность. При прогрессирующей дисплазии тазобедренного сустава у взрослых тотальная артропластика признается безальтернативным хирургическим вмешательством. В научном и практическом аспектах главной задачей артропластики является максимальное восстановление опорно-двигательной функции или компенсация биомеханических нарушений, а также обеспечение условий для продолжительного сохранения стабильности импланта. Цель работы — исследовать факторы, которые определяют результаты тотального эндопротезирования по поводу прогрессирующей дисплазии тазобедренного сустава в средние сроки наблюдения. Материалы и методы. Обследованы 84 пациента, которые перенесли тотальное эндопротезирование по поводу прогрессирующей дисплазии тазобедренного сустава в течение 2014–2019 годов. Сроки оценивания результатов выбрали на основании наблюдений того, что определенный стабильный уровень достигнутого результата формируется в период от 1 до 3 лет в зависимости от тяжести анатомических нарушений. Результаты. Всего выполнено 116 операций тотальной артропластики. Из них по поводу дисплазии I степени по Crowе — 52 (44,8 %), II — 34 (29,4 %), III — 26 (22,4 %), IV — 4 (3,4 %). Концепция исследования заключалась в изучении факторов, которые влияют на выбор хирургической тактики, особенности послеоперационного восстановительного лечения и функциональные результаты в средние сроки наблюдения. Обобщенные результаты по шкале W. Harris: отличные (средний балл — 92,3) — у 39 (46,4 %), хорошие (средний балл — 86,6) — у 26 (30,9 %), удовлетворительные (средний балл — 78,3) — у 15 (17,9 %), неудовлетворительные (средний балл — 67,4) — у 4 (4,8 %). Состояние костных и мягких тканей в области тазобедренных суставов, а также степень анатомических нарушений являются критическим для успешного выполнения артропластики. После артропластики по поводу дисплазии II и III степени наблюдаются хромота, несоответствие длины нижних конечностей, ощущение слабости мышц. Причинные факторы — асимметричность расположения центра ротации тазобедренных суставов, нарушение бедренного офсета, сколиотическая деформация поясничного отдела позвоночника. Выводы. После артопластики по поводу дисплазии тазобедренного сустава пациенты нуждаются в более продолжительном восстановительном лечении, а результаты артропластики определяются степенью достигнутой компенсации анатомических и функциональных нарушений.
PENGEMBANGAN POTENSI TEMAJUK SEBAGAI DESTINASI PARIWISATA DI KABUPATEN SAMBAS
Authors: Evita Rossi , Rosalina Tita 
Published: April 2021

Penelitian ini bertujuan untuk mengidentifikasi potensi wisata Desa Temajuk yang dapat dikembangkan sebagai destinasi pariwisata kabupaten Sambas. Metode yang digunakan adalah penelitian deskriptif kualitatif. Analisis data yang digunakan yaitu analisis deskriptif kualitatif dan analisis SWOT. Hasil yang diperoleh yaitu potensiwisata yang ada di Temajuk di antaranya yaitu Dermaga Camar Bulan, Pasar Rakyat, Pesta Ubur-ubur, Pantai Camar Bulan, Jembatan Mangrouve, Pantai Batu Nenek, dan Teluk Atong, Tanjung Dato’, Gang Durian 8 Batang, Gerbang Perbatasan Indonesia-Malaysia. Dalam pengembangan potensi Temajuk, maka strategi yang digunakan adalah strategi maksimalisasi promosi, strategi pengembangan dan pengelolaan atraksi wisata, strategi peningkatan sumber daya manusia, dan strategi peningkatan keamanan serta pengawasan terhadap aktivitas wisata.
UPAYA PEMULIHAN PARIWISATA BUDAYA PASCA KONFLIK ETNIS DI KECAMATAN SAMBAS KABUPATEN SAMBAS
Authors: Trisnawati Hikmah 
Published: April 2021

This research aims to study get the real understanding about efforts the recovery of cultural tourism after ethnic conflict Madura-Malayu in Sambas District Sambas Regency. Then, to see the problem development cultural tourism and effort of stakeholder to develop tourism in Sambas District. This research used qualitative method. Result of this research are stakeholder have the effort to develop the cultural tourism such as increase the infrastructure, increases human resources management, keep the safety of this regions and gave the promotion of cultural tourism. They have the difficulties of increase the development likes need more integrity of stakehoder beside this; they haven’t good relationship with the Madura Ethnic although many people tried well come to all the ethnic for come to Sambas District.