bluuebunny/crossref_metadata_2025_split huggingface dataset:
Species Sensitivity Distributions of Benthic Macroinvertebrates in Fludioxonil-Spiked Sediment Toxicity Tests
Authors: Sun Jian , Xiao PengFei , Yin XH , Zhang Kun , Zhu Guonian , Brock Theo 
Published: November 2021

Abstract
In China, the fungicide fludioxonil, that accumulates and persists in sediments, has a widespread agricultural use to control various fungal diseases. Its residues may cause toxic effects to benthic aquatic fauna, thereby impacting ecosystem service functions of aquatic ecosystems. To assess the potential environmental effects of fludioxonil in the sediment compartment of edge-of-field surface waters, sediment-spiked single-species toxicity tests with benthic macroinvertebrates were performed. In all experiments artificial sediment was used with an organic carbon content of 2.43% on dry weight basis. The single-species tests were conducted with 8 benthic macroinvertebrates covering different taxonomic groups typical for the Yangtze River Delta, China. The 28d-EC10 and 28-LC10 values thus obtained were used to construct species sensitivity distributions (SSDs). In addition, our data were supplemented with similar fludioxonil-spiked sediment toxicity data for benthic invertebrates from the Netherlands. Based on SSDs constructed with 28d-EC10 values of 8 benthic species from our experiments in China, hazardous concentrations to 5% of the species tested (HC5’s) of respectively 0.57 mg fludioxonil/kg dry weight sediment and 5.4 µg fludioxonil/L pore water were obtained. Supplementing our data from China with 8 similar toxicity data for other benthic species from the Netherlands, these HC5 values became respectively 1.2 mg fludioxonil/kg dry weight sediment and 11 µg fludioxonil/L pore water.
Preoperative QRS Duration Predicts the Responsiveness of Chronic Heart Failure Patients with Pacemaker Indications To Left Bundle Branch Area Pacing Treatment
Authors: Chen Tianping , Geng Xu , Fang Yaxing , Yin Yuchun , Zhang Naiju 
Published: November 2021

Abstract
Background
This study investigated the predictive value of preoperative QRS duration (ORSd) in responsiveness of chronic heart failure (CHF) patients with pacemaker indications to the left bundle branch area pacing (LBBAP).
Methods
Thirty-one CHF patients with cardiac function categorized as NYHA class II or above and indications for pacemaker therapy who successfully underwent LBBAP treatment were enrolled in this study. Based on the 12-month postoperative responsiveness to treatment, patients were divided into a responsiveness group (n=18) and a no-responsiveness group (n=13). Data from all patients were collected for analysis. Multivariate binary logistic regression analysis was used to determine the independent factors associated with the responsiveness to LBBAP treatment.
Results
Among the 31 patients with LBBAP, 16 patients (51.6%) responded to the treatment, and 15 patients (48.4%) had no response. There were significant differences between these two groups with regard to complete left bundle branch block (CLBBB), preoperative QRSd, and preoperative left ventricular peak time (LVAT). Univariate logistic regression analysis showed that CLBBB, preoperative QRSd, and preoperative LVAT were all significantly correlated with responsiveness to LBBAP. Multivariate binary logistic regression analysis showed that ORSd was an independent predictor of responsiveness to LBBAP. The maximum area under the ROC curve for QRSd was 0.827, the maximum Youden index was 0.679, with the optimal cutoff point of QRSd ≥ 153 ms, a sensitivity of 81.3%, and a specificity of 86.7%.
Conclusion
Preoperative ORSd predicts the responsiveness of CHF patients with pacemaker indications to LBBAP.
Assessment of Energy and Environment Footprint of a Proposed Wind Farm in Western Coast of Libya Using LCA
Authors: Elmariami Abdelbari , Elosta Wedad , Elfleet Mohamed , Khalifa Yusef 
Published: November 2021

Abstract
Wind offers Libya an abundant, domestic, and currently untapped carbon free energy resource. This paper describes LCA model of assessment for the identified wind farm near the coastal city Zawia in Libya. The city has been affected by GHG emissions associated with Oil refinery facilities for the last five decades. The model study investigates the life cycle energy performance of the wind farm and the environmental impact category indicators at midpoint level, specifically; acidification and climate change. LCA was conducted to the proposed utility-scale wind farm with total estimated power of 20 MW, the assessment was conducted using the principles of the international standards ISO14040 and 14044. The results demonstrated that the amount of CO2 that can be avoided from the proposed wind farm would be about 2 MtCO2. The other emissions that could be avoided are 352.7 kg CH4 and 63.5 kg N2O. This would contribute to the alleviation of global climate change and global sustainability energy system which is recommended by UN SDG7.
A Full Coverage Reconstruction Algorithm for the Electromagnetic Map Based on Affinity Propagation Clustering
Authors: Lin Dongming , Wang Hongjun 
Published: November 2021

Abstract
Considering the reconstruction of electromagnetic maps without the prior information of electromagnetic propagation environment in the target area, a new algorithm based on affinity propagation clustering is proposed to complete the electromagnetic map reconstruction of the target area from points to surfaces and then from points and surfaces to a larger surface. Firstly, according to the actual situation, the target area is reasonably divided into grids. Electromagnetic data is sampled by distributed sensing nodes, and a certain number of sample points are selected for affinity propagation clustering to determine the locations of centers of sample points. Secondly, for the incomplete sample data, the Kriging algorithm is used to reconstruct the small circular electromagnetic maps. The class center is the center of the circle and the radius is certain. After that, the obtained small area electromagnetic map data and the data obtained from the sample points are used for domain mapping processing, and the electromagnetic data of a larger area of the target area is obtained. Finally, the overall electromagnetic map is reconstructed through data fusion. The simulation results show that the proposed algorithm is better than several interpolation algorithms. When sample points account for 0.1 of total data points, the RMSE of the result is less than 1.5.
Heatwaves and Health Risks in the Northern Part of Senegal: Analysing the Distribution of Temperature Related Diseases and Associated Risk Factors
Authors: Sy Ibrahima , Cissé Birane , Ndao Babacar , Diouf abdoul Aziz , Sarr Mamadou Adama , Ndiaye Ousmane , Ndiaye Youssoupha , Badiane Daouda , Lalou Richard , Janicot Serge , Ndione Jacques-André 
Published: November 2021

Abstract
Backgrond:
The Sahelian zone of Senegal is marked by heatwave events due to temperatures increase especially in 2013 exceeding 45 ° C with an impact on morbidity and mortality rise. In order to document health impacts of recurrent extreme temperatures in this part of the country, a study was carried out combining heatwaves detection, occurrence of climate-sensitive diseases and risk factors for exposure.
Methods
To do this, a set of climatic (temperatures) and health (morbidity, mortality) data were collected for April, May and June season from 2009 to 2019. These data were complemented by surveys on exposure risk factors of 1246 households. Statistical methods were used to carry out univariate and bivariate analyzes while cartographic techniques allowed visualization of the main climatic and health indicators.
Results
The results show an increase in temperatures compared to seasonal normal for the 1971-2000 reference period with threshold exceedances of the 90th percentiles (42°C) for the maxima and (27°C) the minima and higher temperatures during the months of May and June. From health perspective, it was noted an increase in cases of consultation on health facilities as well as a rise in declared morbidity by households especially in the departments of Kanel (17.7%), Ranérou (16.1%), Matam (13.7%) and Bakel (13.7%). The heatwaves of May 2013 were also associated with cases of death with a reported mortality (observed by medical staff) of 12.4% unevenly distributed according to the departments with a higher number of deaths in Matam (25, 2%) and in Bakel (23.5%) than in Podor (8.4%) and Kanel (0.8%). The morbidity and mortality distribution according to gender shows that women (57%) were more affected than men (43%). These health risks have been associated with a number of factors including age, access to drinkable water, type of fuel, type of housing and construction materials, existence of fan, an air conditioner, health antecedents, etc.
Conclusion
The heatwaves recurrence has led to an upsurge in certain diseases sensitive to rising temperatures, which is increasingly a public health issue in the Sahelian zone of Senegal.
Functional Screening and Biosafety Identify of the Potential Application of Let-7a in Injured Peripheral Nerve Regeneration
Authors: Chen Qianqian , Liu Qianyan , Wang Pan , Qian Tianmei , Wang Xinghui , Yi Sheng , Li Shiying 
Published: November 2021

Abstract
Proper supporting factor can possess the ability to enhance neuron regeneration, for instance, neurotrophic effects especially nerve growth factor (NGF). However, the in vivo applications of NGF are largely limited by its intrinsic disadvantages. Considering that let-7 targets and regulates NGF, and let-7 is also the core and harbor regulators in peripheral nerve repair and regeneration, we evaluated the potential application in clinical. We firstly screened the let-7a as the most ideal let-7 family molecular by gene expression analysis and functional approach. We further evaluated the in vivo safety, the cell permeability of 3 main cells in regeneration micro-environment, and the morphological and functional indicators. Our study provides an essential basis for in vivo application of let-7 and pictured a vision for the clinical translation of miRNA as a prospective alternative for regenerative medicine.
Armcx1 Alleviates Secondary Brain Injury After Traumatic Brain Injury by Reducing Apoptosis and Axonal Injury in a Mouse Model of Controlled Cortical Impact
Authors: Lu Dengfeng , Wang Yi , Liu Guangjie , Wang Shixin , Wang Jing , Sun Xiaoou , Wu Yu 
Published: November 2021

Abstract
Armcx1 is highly expressed in the brain and is located in the mitochondrial outer membrane of neurons, where it mediates mitochondrial transport. Mitochondrial transport promotes the removal of damaged mitochondria and the replenishment of healthy mitochondria, which are essential for neuronal survival after traumatic brain injury (TBI). This study investigated the role of Armcx1 and its underlying regulator(s) in secondary brain injury (SBI) after TBI. An in vivo TBI model was established in C57BL/6 mice via controlled cortical impact (CCI). Adeno-associated viruses with Armcx1 overexpression and knockdown were constructed and administered to mice by stereotactic cortical injection. Exogenous miR-223-3P mimic or inhibitor was transfected into cultured cortical neurons, which were then scratched to simulate TBI in vitro. The Armcx1 protein level was found to be decreased in peri-lesion tissue, particularly in neurons. The overexpression of Armcx1 significantly reduced TBI-induced neurological dysfunction, apoptosis, axonal injury, and mitochondrial dysfunction, while knockdown of Armcx1 had the opposite effect. Armcx1 was a direct target of miR-223-3P. The miR-223-3P mimic significantly reduced the Armcx1 protein level, while the miR-223-3P inhibitor had the opposite effect. Finally, the miR-223-3P inhibitor significantly improved mitochondrial membrane potential and increased the total length of the neurites without affecting branching numbers, while the miR-223-3P mimic had the opposite effect. In summary, our results suggest that the decreased expression of Armcx1 protein in neurons after experimental TBI aggravates secondary brain injury, which may be regulated by miR-223-3P. Therefore, this study provides a potential therapeutic approach for treating TBI.
WITHDRAWN: Preparation of Silver Nanopowders and Its Application in Low Temperature Electrically Conductive Adhesive
Authors: Zhang Xiao Min , Yang Xiao-Li , Wang Bin 
Published: November 2021

Abstract
Printable electrically conductive adhesive with high electrical conductivity and good mechanical properties has wide application prospect in electronic device. In order to explore new conductive fillers of interconnecting materials in electronic circuit and electronic packaging industries, silver nanopowders were prepared by DC arc plasma method with high pure. The silver nanopowders present a spherical structure, the particle’s diameter range from 15 to 220 nm. In this paper, a high performance electrically conductive adhesive (ECA) was prepared. This ECA was fabricated by mixing silver nanopowders with epoxy resin and was screen-printed to a required shape. It was found that the ECA can be solidified through a low temperature sintering method in the air at 150 ℃ for 10 min. The electrical and mechanical of above ECA were investigated and characterized. The ECA filled with 75% silver nanopowders exhibits excellent performances, including high electrical conductivity (9.5×10-4 Ω·cm), high bonding strength ( 8.3 MPa). Based on the performance characteristics, the ECA applications in flexible printed electrodes and interconnecting materials are demonstrated.
AURKA/NFκB Axis: A Key Determinant of Radioresistance in Cervical Squamous Carcinoma Cells
Authors: Das Salini , Ray Dilip Kumar , Mahapatra Elizabeth , Biswas Souvick , Roy Madhumita , Mukherjee Sutapa 
Published: November 2021

Abstract
Background: Cervical cancer being one of the leading gynaecological cancers, possess a major threat by its ever-increasing trend of global recurrence events. Radioresistance is one of the major challenges confronted during the treatment of cervical cancer. Radioresistance in cancer cells is manifested by increased rate of cellular proliferation, migration-invasion and cell cycle alterations. Aurora Kinase A (AURKA), a mitotic serine/threonine kinase was found to be overexpressed in cancers and is associated with development of acquired therapy resistance. The principal objective of this study revolved with exploring the mechanisms by which AURKA confers radioadaptive response in cervical cancer cells. Methods and Results: Parental cervical squamous carcinoma cell line SiHa was subjected to recurrent insult by fractionated dose of X-irradiation. Finally, a resistant subline (SiHa/RR) was isolated at 40Gy. SiHa/RR exhibited higher expression of AURKA/ pAURKA along with the signaling molecules that are favored by this kinase (HIF1α, pAkt, NFκB) vis-à-vis lower expressions of the molecules that are generally suppressed by AURKA (p53, Gadd45a). Surprisingly, inhibition of AURKA in SiHa/RR showed improved radiosensitivity by reducing the wound healing capacity, sphere forming ability and enhancing radiation induced apoptosis. Ectopic overexpression of AURKA gave rise to radioresistant phenotype in parental SiHa by stimulating nuclear translocation of NFκB. This pattern of increased nuclear localization of NFκB was also observed in resistant subline as a consequence of activation and overexpression of AURKA. Conclusion: These findings strengthened the involvement of AURKA in radioresistance via activating NFκB mediated signaling pathway to deliver radioresistant associated adaptive complexities.
PAHs Changed Epigenetics by One Carbon Metabolism in Childhood Asthma
Authors: Wu Hao , Bao Yuling , Hu Jinye , Huang Hui , Jiang Ping , Zhang Zhan , Li Lei , Wu Qian 
Published: November 2021

Abstract
Background: Epigenetic mechanisms may play a role in which PAHs exert its adverse effects in childhood asthma. However, the underlying molecular mechanism remain to be fully elucidated. This study aimed to investigate this process in view of cellular metabolism, especially one carbon metabolism. Methods: Fifty asthmatic children and fifty control subjects were recruited in this study. Serum IgE and IL-17A was detected by ELISA assay. Serum PAHs levels were measured by GC-MS. One carbon-related metabolites were determined by UPLC-Orbitrap-MS. Blood DNA methylation in long interspersed nucleotide element-1 (LINE-1) was analyzed by bisulfite sequencing PCR. ChIP assays were used to examine H3K4me3 modifications on IL-17A gene. Multivariable linear regression was performed to evaluate the associates between PAHs and DNA methylation and histone methylation mediated by one carbon metabolism. Results: The asthmatic group presented significantly higher total serum IgE and IL-17A levels. Serum Fla was associated with childhood asthma. The asthmatic group displayed a significantly decreasing in SAM abundance and a smaller but corresponding decrease in SAH, which indicated the increasing conversion from SAM to SAH and the elevated capacity of methylation reactions. Fla had a great effect on one carbon metabolites, especially SAH, SAM and Ser, which exerted significant mediation effects between the Fla level and asthma. What’s more, Fla had a positive effect on LINE-1 DNA methylation (β=0.395, P=0.000) and H3K4 tri-methylation level in the IL-17A promoter region(β=0.293, P=0.002). We did find significant mediation effect between serum Fla and asthma by LINE-1 DNA methylation and H3K4me3 level in the IL-17A promoter region.Conclusion: PAHs disturbed one carbon metabolism to influence the methyl group refill of DNA methylation and histone methylation, which may elevate serum IL-17A level in asthmatic children.
Source Apportionment and Model Applicability of Heavy Metal Pollution in Farmland Soil Based on Three Receptor Models
Authors: Liu Hong , Liao Shiyan , Wu Dongtao , Rukh Gul , Chen Zhenhua , Wu Xiangdong , Xiao Linlin , Zhong Bin , Liu Dan 
Published: November 2021

Abstract
The identification of the source of heavy metal pollution and its quantification are the prerequisite of soil pollution control. The apcs-mlr, UNMIX and PMF models were employed to apportion pollution sources of Cu, Zn, Pb, Cd, Cr and Ni of the farmland soil in vicinity of an abandoned iron and steel plant. The sources, contribution rates and applicability of the models were evaluated. The potential ecological risk index revealed greatest ecological risk from Cd. The results of source apportionment illustrated that apcs-mlr and UNMIX models can verify each other for accurate allocation of pollution sources. The industrial sources were the main sources of pollution (32.41% ~ 38.42%), followed by agricultural sources (29.35% ~ 31.65%), traffic emission sources (21.03% ~ 21.51%), and natural sources of pollution were accounted for smallest proportion (11.2% ~ 14.42%). The PMF model was easily affected by outliers, its fitting degree was not ideal, and it was unable to get more accurate results of source analysis. The combination of multiple models can effectively improve accuracy of pollution source analysis of soil heavy metals. These results can provide a scientific basis for further remediation of heavy metal pollution in farmland soil.
The aerodynamic performance of Non-planar hex-rotors aircraft subjected the horizontal wind disturbanceLei yao1,2* Ma Chensong1 Feng Zhicheng1
Authors: yao Lei , Chensong Ma , Zhicheng Feng 
Published: November 2021

Abstract
The non-planar hex-rotor aircraft mentioned in this article can change its flight status by simply changing the tilt angle of the rotor. In this paper, mainly studied the best aerodynamic performance of a non-planar hex-rotor aircraft under the influence of horizontal wind (0m/s, 2.5m/s and 4m/s). Firstly, the rotation speed of the rotor is a fixed value (2200r/min) in the low-speed wind tunnel test, the horizontal wind speed and the tilt angle of the rotor are variable values, the thrust, power consumption and power loading(PL) values of the aircraft are obtained. Secondly, the computational fluid dynamics(CFD) method is used to simulate the aerodynamic performance of a non-planar hex-rotors aircraft when subjected to a horizontal wind to obtain the simulation results. Finally, comparing the experimental values and the simulation values, it is found that the horizontal speed has a greater impact on the thrust and power consumption of the non-planar hex-rotor aircraft. From the change of PL values, it is concluded that the horizontal wind speed is 0m/s, 2.5m/s, 4m/s, the best inclination angle is 10°, 30°and 50°, and the strongest anti-wind performance.
Research on Siding Mode Controller of High-Speed Maglev Train Under Aerodynamic Load
Authors: Liu Meng-juan , Wu Han , Zeng Xiao-Hui , Yin Bo , Hao Zhan-zhou 
Published: November 2021

Abstract
The high-speed maglev train will be subjected to extremely obvious aerodynamic load during operation, it will also be subjected to instantaneous aerodynamic impact load in the case of passing, which will bring extreme challenges to the suspension stability and safe operation of the train. It is necessary to consider the influence of aerodynamic load and shock wave in the design of suspension control algorithm. Traditional proportion integration differentiation (PID) control cannot follow the change of vehicle parameters or external disturbance, which is easy to cause suspension fluctuation and instability. In order to improve the suspension stability and vibration suppression of high-speed maglev train under aerodynamic load and impact, a controller based on sliding mode technique is designed in this paper, and in this controller, the deformation of the primary suspension is introduced to replace the aerodynamic load on the electromagnet. In order to verify the control performance of the designed controller, the dynamic simulation model of train with three vehicles is established, and the dynamic response of the train under the condition of passing in open air is calculated. Compared with the PID controller, it is verified that the sliding mode control (SMC) method proposed in this paper can effectively restrain the electromagnet fluctuation of the train under aerodynamic load.