bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH STRESS KERJA TERHADAP KINERJA KARYAWAN PADA PT. PLN (PERSERO) AREA PONDOK AREN, TANGERANG SELATAN
Authors: Nelsi Mitri 
Published: May 2021

Penelitian ini bertujuan untuk mengetahui pengaruh stress kerja terhadap kinerja karyawan pada PT. PLN (Persero) Area Pondok Aren, Tangerang Selatan.Metode yang digunakan adalah explanatory research dengan sampel sebanyak 86 responden. Teknik analisis menggunakan analisis statistik dengan pengujian regresi, korelasi, determinasi dan uji hipotesis.Hasil penelitian ini variabel stress kerja diperoleh nilai rata-rata skor sebesar 3,486 dengan kriteria baik. Variabel kinerja karyawan diperoleh nilai rata-rata skor sebesar 3,076 dengan kriteria baik. Stress kerja berpengaruh positif dan signifikan terhadap kinerja karyawan dengan nilai persamaan regresi Y = 50,558 - 0,568X, dan nilai koefisien korelasi - 0,626 atau memiliki tingkat hubungan yang negatif kuat dengan nilai determinasi 39,2%. Uji hipotesis diperoleh signifikansi 0,000 < 0,05.
PENGARUH PELATIHAN TERHADAP KINERJA KARYAWAN PADA PT. ESSAR DHANANJAYA DI CIBITUNG - BEKASI
Authors: Rajak Muhammad Abdul 
Published: May 2021

Penelitian ini bertujuan untuk mengetahui pengaruh pelatihan terhadap kinerja karyawan pada PT. Essar Dhananjaya di Cibitung-Bekasi. Metode yang digunakan adalah explanatory research dengan sampel sebanyak 100 responden. Teknik analisis menggunakan analisis statistik dengan pengujian regresi, korelasi, determinasi dan uji hipotesis. Hasil penelitian ini variabel pelatihan diperoleh nilai rata-rata skor sebesar 3,41 dengan kriteria baik. Variabel kinerja karyawan diperoleh nilai rata-rata skor sebesar 3,84 dengan kriteria baik. Pelatihan berpengaruh positif dan signifikan terhadap kinerja karyawan dengan nilai persamaan regresi Y = 9,323 + 0,852X, dan nilai koefisien korelasi 0,777 atau memiliki tingkat hubungan yang kuat dengan nilai determinasi 60,3%. Uji hipotesis diperoleh signifikansi 0,000 < 0,05.
tratamento do xénero poético en Ricardo Carballo Calero. Crítica literaria, canon e historiografía
Authors: Valverde Alberte 
Published: May 2021

Nesta intervención, o obxectivo principal é a revisión da produción ensaística de Ricardo Carballo Calero centrada no xénero poético do século XX. Deste xeito, o eixe temporal que se vai abranguer transita dende os inicios na revista Nós até a presentación da súa magna obra Historia da literatura galega contemporánea, na edición definitiva de 1979. Asemade, cotexarase con diferentes calas representativas en textos do profesor e doutros axentes do campo. En concreto, este traballo pretende partir da produción deste autor para observar como se concibe e desenvolve a crítica no campo literario galego do século pasado.
Ao mesmo tempo, incidirase na proposta que realiza Carballo Calero dun canon poético para o século XX e mais a súa achega na construción dunha historiografía científica ligada ao nacionalismo literario incipiente. Desta maneira, acóutase unha obra que se considera determinante na hora de escoller uns habitus concretos na crítica e historiografía galega que se manteñen até os nosos días.
LATIHAN RELAKSASI OTOT PROGRESIF UNTUK MENURUNKAN TEKANAN DARAH PENDERITA HIPERTENSI DI RT 13 KELURAHAN 29 ILIR KECAMATAN ILIR BARAT II WILAYAH KERJA PUSKESMAS MAKRAYU PALEMBANG
Authors: . Azwaldi , . Rumentalia , Erman Imelda 
Published: May 2021

Angka kejadian hipertensi semakin meningkat setiap tahunnya. WHO memperkirakan tahun 2025 terdapat 1,15 milyar kasus atau sekitar 29% dari total penduduk dunia menderita hipertensi, dimana 333 juta berada di negara maju dan 639 sisanya berada di negara berkembang, termasuk di Indonesia. Kejadian hipertensi yang meningkat setiap tahunnya mengindikasikan bahwa hipertensi perlu dan harus segera diatasi. Oleh sebab itu, penanganan hipertensi berupa pengobatan maupun perawatan dini sangat penting karena hipertensi merupakan suatu penyakit kronis yang harus dikontrol seumur hidup. Kegiatan ini bertujuan memberi pelatihan relaksasi otot progresif untuk mengurangi ketegangan atau kecemasan dengan menciptakan suasana dan perasaan relaks bagi penderita hipertensi, sehingga menurunkan tekanan darah penderita hipertensi. Metode kegiatan berupa demonstrasi, latihan pemeriksaan tekanan darah sebelum dan setelah latihan relaksasi otot progresif dan pendidikan kesehatan. Hasil Kegiatan menunjukkan penurunan tekanan darah sebesar 10-15 mmHg setelah dilakukan latihan relaksasi otot Progresif.
Authors: Rochman Syaiful , . Nirwana , Sakti Indra , Yanuar Zukmadini Alif 
Published: May 2021

This activity was conducted to provide training to teachers of SMA Negeri 1 Bengkulu Tengah as one of the solutions in improving the ability to use Physics KIT in practicum activities. This training is expected to improve the ability of students in the school in carrying out physical practicum activities, especially in using practicum kit tools. To achieve this goal, training activities are carried out with scientific approaches conducted by means, holding workshops on the use of physical KIT tools, conducting simulations of the use of physical KIT tools, conducting coaching and evaluation. The results of the overall evaluation of the activity showed the student's response during the activity was included in the good category, and the ability of participants in using physics KIT also belonged to the good category. The conclusion in this activity is that scientific approach-based physics kit assistance training can improve students' ability to use practicum kits.

Keywords: Training, KIT, Physics, Scientific, Approach
Effect of Integrated Use of Rhizobium Inoculum and Phosphorus Fertilization on Nodulation, Growth, and Yield of Soyabean CV. Binasoybean-2
Authors: Hasan Kamrul , Hoshain Shohrab , Sharmin Tamanna , Rabbani Md Golam , Azad Md Saiful Kamal , Rahman Md Rashedur , Kar Partha Sarathi 
Published: May 2021

The experiment was carried out to investigate the effect of rhizobium inoculum and phosphorus fertilization on nodulation, growth, and yield of soyabean cv. Binasoybean-2 at the area of Chamberkella, East Subarnachar Upazila, Noakhali, Bangladesh, from mid-January to first week of May 2018. Four levels of Rhizobium inoculation viz: 0, 25, 50 and 75 g kg-1 and four levels of phosphorus viz: 0, 18, 36 and 54 kg P ha-1 were applied. The experiment was laid out in a randomized complete block design (RCBD) with three replications. The effect of interaction of different combinations of Rhizobium inoculation and phosphorus rates showed regular trend, although their effects on some of studied growth, and yield parameters were insignificant but most of the growth and yield parameters were significant. Among sixteen treatment combinations the highest grain yield (2.217 t ha-1) was obtained from the treatment combination of 50 g kg-1 Rhizobium inoculation and 36 kg ha-1 phosphorus which was statistically identical with 50 g kg-1 Rhizobium inoculation with 18 kg ha-1, the lowest yield (1.367 t ha-1) was recorded with control treatment.
Res. Agric., Livest. Fish.8(1): 9-17, April 2021
Prevalence of Visceral Schistosomiasis in Cattle Slaughtered in North-Eastern Region of Bangladesh
Authors: Abdullah SM , Mohanta Uday Kumar 
Published: May 2021

A cross sectional study was conducted to estimate the prevalence and identify possible risk factors (season, sex) of Schistosoma in three north-eastern districts of Bangladesh namely Mymensingh, Sunamganj, Kishoreganj. Mesenteric sample of cattle from different slaughter houses were collected and examined for helminths which were identified as Schistosoma on accordance with Soulbsy, 1965. Total 67 (55.83%) out of 120 randomly selected samples were found positive for schistosomiasis. Cattle of Kishoreganj were mostly infected (67.50%), followed by Sunamganj (55.00%) and Mymensingh (45.00%). Regarding seasonal prevalence, samples collected during winter (63.33%) were more infected than summer (48.33%). Moreover, 58.69% of male and 46.42% of female were found infected. In conclusion, relatively high prevalence was recorded in the study areas based on the results obtained. Hence, control measures against schistosomiasis must be designed.
Res. Agric., Livest. Fish.8(1): 165-169, April 2021
Perfil socioambiental de idosos de uma região do Pantanal Matogrossense: Um estudo das endoparasitoses
Authors: Matos Tatiane Amorim de , Zanetti Andernice dos Santos , Barros Lucas França de , Araújo Marta dos Santos Miranda de , Espinosa Omar  Ariel , Malheiros Antonio Francisco 
Published: May 2021

Como o processo natural do envelhecimento, o idoso apresenta mudanças morfofisiológicas e imunológicas deixando o mais susceptível as infecções parasitárias. As endoparasitoses constituem um problema de saúde pública no Brasil, apresentando variações de acordo com as condições de saneamento básico, nível socioeconômico, grau de escolaridade, idade e hábitos de higiene, entre outras variáveis. O objetivo geral deste trabalho foi analisar a prevalência de endoparasitas em idosos frequentadores do Centro de Convivência e idosos e funcionários da Instituição de Longa Permanência no município de Cáceres-MT. As amostras foram analisadas empregando três técnicas laboratoriais, sendo elas: Hoffmann, Ritchie e técnica de coloração Safranina modificado, no laboratório de Biologia Parasitaria da Universidade do Estado do Mato Grosso (UNEMAT). A prevalências de parasitas intestinais entre os idosos do Centro de Convivência (46,98%), idosos da Instituição de Longa Permanência (83,33%) e funcionários (84,61%). Os endoparasitas Criptosporidium sp., Cyclospora sp. e Giardia lamblia foram os mais prevalentes, com 22%, 19% e 18%, respectivamente. Esse estudo avaliou ainda as características sociodemográficas e hábitos de higiene pessoal dos idosos do Centro de Convivência e dos funcionários da ILP. Os resultados sugeriram uma condição epidemiológica preocupante da população idosa da ILP pois os altos índices de prevalência tanto nos idosos quanto nos funcionários evidenciam o alto risco de infecção e reinfecção nesse ambiente e mostra a necessidade de programas educacionais de conscientização das práticas higiênicas e de atenção básica a saúde da população idosa nessas instituições.
Autonomous Non Antioxidant Roles for Fasciola hepatica Secreted Thioredoxin-1 and Peroxiredoxin-1
Authors: Dorey Amber , Cwiklinski Krystyna , Rooney James , De Marco Verissimo Carolina , López Corrales Jesús , Jewhurst Heather , Fazekas Barbara , Calvani Nichola Eliza Davies , Hamon Siobhán , Gaughan Siobhán , Dalton John P. , Lalor Richard 
Published: May 2021

Trematode parasites of the genus Fasciola are the cause of liver fluke disease (fasciolosis) in humans and their livestock. Infection of the host involves invasion through the intestinal wall followed by migration in the liver that results in extensive damage, before the parasite settles as a mature egg-laying adult in the bile ducts. Genomic and transcriptomic studies revealed that increased metabolic stress during the rapid growth and development of F. hepatica is balanced with the up-regulation of the thiol-independent antioxidant system. In this cascade system thioredoxin/glutathione reductase (TGR) reduces thioredoxin (Trx), which then reduces and activates peroxiredoxin (Prx), whose major function is to protect cells against the damaging hydrogen peroxide free radicals. F. hepatica expresses a single TGR, three Trx and three Prx genes; however, the transcriptional expression of Trx1 and Prx1 far out-weighs (&gt;50-fold) other members of their family, and both are major components of the parasite secretome. While Prx1 possesses a leader signal peptide that directs its secretion through the classical pathway and explains why this enzyme is found freely soluble in the secretome, Trx1 lacks a leader peptide and is secreted via an alternative pathway that packages the majority of this enzyme into extracellular vesicles (EVs). Here we propose that F. hepatica Prx1 and Trx1 do not function as part of the parasite’s stress-inducible thiol-dependant cascade, but play autonomous roles in defence against the general anti-pathogen oxidative burst by innate immune cells, in the modulation of host immune responses and regulation of inflammation.
Essential Genes and MiRNA–mRNA Network Contributing to the Pathogenesis of Idiopathic Pulmonary Arterial Hypertension
Authors: Hao Shengyu , Jiang Pan , Xie Liang , Xiang Guiling , Liu Zilong , Hu Weiping , Wu Qinhan , Jiang Liyan , Xiao Yi , Li Shanqun 
Published: May 2021

Background: Idiopathic pulmonary arterial hypertension (IPAH) is a life-threatening disease. Owing to its high fatality rate and narrow therapeutic options, identification of the pathogenic mechanisms of IPAH is becoming increasingly important.Methods: In our research, we utilized the robust rank aggregation (RRA) method to integrate four eligible pulmonary arterial hypertension (PAH) microarray datasets and identified the significant differentially expressed genes (DEGs) between IPAH and normal samples. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were performed to analyze their functions. The interaction network of protein–protein interaction (PPI) was constructed to explore the correlation between these DEGs. The functional modules and hub genes were further identified by the weighted gene coexpression network analysis (WGCNA). Moreover, a miRNA microarray dataset was involved and analyzed to filter differentially expressed miRNAs (DE-miRNAs). Potential target genes of screened DE-miRNAs were predicted and merged with DEGs to explore a miRNA–mRNA network in IPAH. Some hub genes were selected and validated by RT-PCR in lung tissues from the PAH animal model.Results: A total of 260 DEGs, consisting of 183 upregulated and 77 downregulated significant DEGs, were identified, and some of those genes were novel. Their molecular roles in the etiology of IPAH remained vague. The most crucial functional module involved in IPAH is mainly enriched in biological processes, including leukocyte migration, cell chemotaxis, and myeloid leukocyte migration. Construction and analysis of the PPI network showed that CXCL10, CXCL9, CCR1, CX3CR1, CX3CL1, CXCR2, CXCR1, PF4, CCL4L1, and ADORA3 were recognized as top 10 hub genes with high connectivity degrees. WGCNA further identified five main functional modules involved in the pathogenesis of IPAH. Twelve upregulated DE-miRNAs and nine downregulated DE-miRNAs were identified. Among them, four downregulated DEGs and eight upregulated DEGs were supposed to be negatively regulated by three upregulated DE-miRNAs and three downregulated DE-miRNAs, respectively.Conclusions: This study identifies some key and functional coexpression modules involved in IPAH, as well as a potential IPAH-related miRNA–mRNA regulated network. It provides deepening insights into the molecular mechanisms and provides vital clues in seeking novel therapeutic targets for IPAH.
Circulating Carboxylated Osteocalcin Correlates With Skeletal Muscle Mass and Risk of Fall in Postmenopausal Osteoporotic Women
Authors: Vitale Jacopo Antonino , Sansoni Veronica , Faraldi Martina , Messina Carmelo , Verdelli Chiara , Lombardi Giovanni , Corbetta Sabrina 
Published: May 2021

BackgroundBone and skeletal muscle represent a single functional unit. We cross-sectionally investigated body composition, risk of fall and circulating osteocalcin (OC) isoforms in osteoporotic postmenopausal women to test the hypothesis of an involvement of OC in the bone-muscle crosstalk.Materials and MethodsTwenty-nine non-diabetic, non-obese, postmenopausal osteoporotic women (age 72.4 ± 6.8 years; BMI 23.0 ± 3.3 kg/m2) underwent to: 1) fasting blood sampling for biochemical and hormone assays, including carboxylated (cOC) and uncarboxylated (uOC) osteocalcin; 2) whole-body dual energy X-ray absorptiometry (DXA) to assess total and regional body composition; 3) magnetic resonance imaging to determine cross-sectional muscle area (CSA) and intermuscular adipose tissue (IMAT) of thigh muscles; 4) risk of fall assessment through the OAK system.ResultsAppendicular skeletal muscle index (ASMMI) was low in 45% of patients. Forty percent got a low OAK score, consistent with moderate-severe risk of fall, which was predicted by low legs lean mass and increased total fat mass. Circulating cOC levels showed significantly correlated with βCTx-I, lean mass parameters including IMAT, and OAK score. Fractured and unfractured women did not differ for any of the analyzed parameters, though cOC and uOC positively correlated with legs lean mass, OAK score and bone markers only in fractured women.ConclusionsData supported the relationship between OC and skeletal muscle mass and function in postmenopausal osteoporotic women. Serum cOC, but not uOC, emerges as mediator in the bone-muscle crosstalk. Circulating cOC and uOC levels may be differentially regulated in fractured and unfractured osteoporotic women, suggesting underlying differences in bone metabolism.
Hydrogen from Dark Fermentation of the Organic Fraction of Waste Diapers: Optimization Based on Response Surface Experiments
Authors: Sotelo-Navarro Perla X. , Poggi-Varaldo Héctor M. 
Published: May 2021

Waste diapers (WD) handling and disposal in Mexico are typically based on their burial in dumping sites and landfills. Practically reclaiming and recycling of WD are non-existent. The clean diapers are composed of cellulose fibres (37–43% db), hemicellulose (5–9%), lignin (4–7%), protein (&lt;1), plastics (polypropylene and polyethylene) (12–16%), absorbent sodium polyacrylate (14–18%), and elastic and adhesives tapes (9–12%). The latter can be valuable resources. WD composition is similar to clean diaper, although humidity is very high, and the ranges of faeces and urine are 1.5–2.5 and 6–9% dry weight, respectively. International literature searches indicate that there is some research on composting, fungal biodegradation, and methanogenic co-digestion of waste activated sludge with the organic fraction of waste diapers (OFWD.) However, research on dark fermentation of OFWD is limited. In this work, the generation of biohydrogen from dark fermentation of OFWD was optimised. We used the response surface methodology (RSM). Independent variables were the temperature of operation (37–55°C), ratio C/N of the feed (30, 40 gC/gN), and initial total solids of the feed (TSi) (15, 25%). The dependent (response) variables examined were Y’H2 (H2 produced per initial g of dry matter), contents of low molecular weight organic solvents and acids, lactic acid, the ratio A/B (acetic-to-butyric acid), and the quotient organic acids C2 to C4-to-solvents. The predicted maximum Y’H2 occurred at the combination of factors of 43 gC/gN, 12% and 31°C; its value was 2.79 mmolH2/gTS; its experimental validation gave 2.48 mmolH2/gTS, which shows a good agreement between values (11% lower than the predicted value). The maximum of Y’H2 with OFWD compared very favourably with bioH2 values obtained from a wide variety of wastes (organic municipal residues, agricultural wastes, etc.) using the same batch type fermentation with intermittent venting. Interestingly, the predicted temperature optimum fell in the lower side of the mesophilic range. Process heating savings would be in the order of 60.0 and 27.2% for thermophilic and mesophilic operation, respectively. In this way, it would be a contribution to the sustainability of the dark fermentation of OFWD. This result was somewhat counterintuitive and strongly indicates the usefulness of the response surface methodolog for analyzing the experimental results and uncovering favourable, although unexpected conditions.
Agonistic β2-Adrenergic Receptor Autoantibodies Characterize the Aqueous Humor of Patients With Primary and Secondary Open-Angle Glaucoma
Authors: Hohberger Bettina , Wörn Max , Lämmer Robert , Mahajan Aparna , Mardin Christian , Schötzer-Schrehardt Ursula , Kunze Rudolph , Herrmann Martin , Wallukat Gerd 
Published: May 2021

PurposeAgonistic β2-adrenergic receptor autoantibodies (β2-agAAbs) were recently observed in sera of patients with ocular hypertension (OHT), primary (POAG), and secondary open-angle glaucoma (SOAG), yet not in healthy controls (HCs). It was the aim of the present study to investigate the presence of β2-agAAb in aqueous humor (AH) samples of OAG patients and to correlate these with the corresponding β2-agAAb serum data.Material and MethodsThirty-nine patients (21 male, 18 female) were recruited from the Department of Ophthalmology, University of Erlangen-Nürnberg: twenty-one POAG, 18 SOAG. Aqueous humor samples were collected during minimal invasive glaucoma surgery. Serum and AH samples were analyzed for β2-agAAb by a bioassay quantifying the beating rate of cultured cardiomyocyte (cut-off: 2 U).ResultsThirty-six of 39 (92.3%) and 34 of 39 (87.2%) of OAG patients showed a β2-agAAb in their sera and AH samples, respectively. All β2-agAAb AH-positive OAG patients were also seropositive. We also observed a β2-agAAb seropositivity in 95 and 89% of patients with POAG and SOAG, respectively. Beta2-agAAbs were seen in 86% (POAG) and 78% (SOAG) of AH samples. The β2-agAAb adrenergic activity was increased in the AH of patients with POAG (6.5 ± 1.5 U) when compared with those with SOAG (4.1 ± 1.1 U; p = 0.004). Serum β2-agAAb adrenergic activity did not differ between the cohorts [POAG (4.5 ± 1.5 U); SOAG (4.6 ± 2.1 U; p=0.458)]. No correlation of the beating rates were observed between serum and AH samples for group and subgroup analyses.ConclusionThe detection of β2-agAAb in systemic and local circulations supports the hypothesis of a direct functional impact of these agAAbs on ocular G-protein coupled receptors. The high prevalence of β2-agAAb in serum and AH samples of patients with POAG or SOAG suggests a common role of these AAbs in the etiopathogenesis of glaucoma, independent of open-angle glaucoma subtype.
Prediction of Re-positivity for Coronavirus Nucleic Acid Among COVID-19 Patients in the Recovery Phase
Authors: Zhu Shu-fen , Sun Bo , Li Jin-kuang , Cai Yue , Li Peng-fei , Hong Ji-chang , Li Jin-hai , Xu Shi-wen , Li Xiao-yang , Xue Chen-wei , Gu Bin-bin , Wu Jian-fen , Zhou Xian-bin , Suo Hong , Duan Pei-lin , Wu Xin-xin , Li Shao-wei 
Published: May 2021

Background and Objectives: Although the pathogenesis and treatment of coronavirus disease 2019 (COVID-19) have been gradually revealed, the risk for re-emergence of coronavirus nucleic acids in recovered patients remains poorly understood. Hence, this study evaluated the risk predictors associated with re-positivity for virus nucleic acid.Methods: Between February 1 and March 20, 2020, we retrospectively reviewed the clinical epidemiological data of 129 COVID-19 patients who were treated at Zhongxiang People's Hospital of Hubei Province in China. Subsequently, a risk prediction model for the re-positivity of virus nucleic acid was developed, and a receiver operating characteristic (ROC) curve was drawn for further validation.Results: In this study, the rate of re-positivity for virus nucleic acid was 17.8% (23/129) where all re-positivity cases were asymptomatic. The median time interval from discharge to nucleic acid re-positivity to discharge after being cured again was 11.5 days (range: 7–23 days). Multivariate logistic regression analysis showed that leukocytopenia [odds ratio (OR) 7.316, 95% confidence interval (CI) 2.319–23.080, p = 0.001], prealbumin &lt; 150 mg/L (OR 4.199, 95% CI 1.461–12.071, p = 0.008), and hyperpyrexia (body temperature &gt;39°C, OR 4.643, 95% CI 1.426–15.117, p = 0.011) were independent risk factors associated with re-positivity. The area under the ROC curve was 0.815 (95% CI, 0.729–0.902).Conclusion: COVID-19 patients with leukocytopenia, low prealbumin level, and hyperpyrexia are more likely to test positive for virus nucleic acid after discharge. Timely and effective treatment and appropriate extension of hospital stays and quarantine periods may be feasible strategies for managing such patients.