bluuebunny/crossref_metadata_2025_split huggingface dataset:
Naturally Sourced CDK Inhibitors and Current Trends in Structure-Based Synthetic Anticancer Drug Design by Crystallography
Authors: Nandi Sisir , Dey Rishita , Dey Sudatta , Samadder Asmita , Saxena Anil Kumar 
Published: September 2021

Abstract:Cyclin-dependent kinases (CDKs) are the chief regulators in cell proliferation; the kinase activities are largely regulated by their interactions with CDK inhibitors (CKIs) and Cyclins. The association of different CDKs with CDKIs and Cyclins at the cell-cycle checkpoints of different stages of mitotic cell cycle function act more likely as the molecular switches that regulate different transcriptional events required for progression through the cell cycle. A fine balance in response to extracellular and intracellular signals is highly maintained in the orchestrated function of CDKs along with Cyclins and CDKIs for normal cell proliferation. This fine-tuning in mitotic cell cycle progression sometimes gets lost due to dysregulation of CDKs. The aberrant functioning of the CDKIs is therefore studied for its contributions as a vital hallmark of cancers. It has attracted our focus to maneuver cancer therapy. Hence, several synthetic CDKIs and their crystallography-based drug design have been explained to understand their mode of action with CDKs. Since most of the synthetic drugs function by inhibiting the CDK4/6 kinases by competitively binding to their ATP binding cleft, these synthetic drugs are reported to attack the normal, healthy growing cells adjacent to the cancer cells leading to the decrease in the life span of the cancer patients. The quest for traditional natural medicines may have a great impact on the treatment of cancer. Therefore, in the present studies, a search for naturally sourced CDK inhibitors has been briefly focused. Additionally, some synthetic crystallography-based drug design has been explained to elucidate different avenues to develop better anticancer chemotherapeutics, converting natural scaffolds into inhibitors of the CDK mediated abnormal signal transduction with lesser side effects.
Synthesis, Physicochemical, Computational and Biological Evaluation of Phenylurea Derivatives as CNS Agents
Authors: Verma Shweta , Singh Sandeep 
Published: September 2021

Background:
A series of phenylurea derivatives were designed and synthesized, The target
compounds were subjected to pharmacological studies. Various other parameters such as physicochemical
properties, computational studies, and % similarity were also calculated.

Materials and Methods:
The synthesis of the target compounds has been carried out by reaction of
Phenylurea with chloroacetyl chloride to afford 1-(2-chloroacetyl)-3-phenylurea, which further reacted
with substituted anilines. All the reactions were monitored by TLC. All the target compounds
were purified by recrystallization and characterized by spectroscopic methods. Physicochemical parameters
and Log P values of the synthesized derivatives were also calculated. It identified compounds
that have the prospect to cross the blood-brain barrier (BBB) and are CNS active. Skeletal
muscle relaxant activity was also carried out using the Rotarod method.

Results:
The data of Log P indicated that the synthesized compounds have the potential to cross
the BBB, so they are CNS active. Pharmacological activities of the derivatives showed that the
compounds containing chloro group have moderate skeletal muscle relaxant activity. The test compounds
possess significant differences between the control group and the treated group.

Conclusion:
The synthesized derivatives containing chloro group were found to be more potent
when compared to standard drug Diazepam. Various others parameters studied revealed that the
drug has the potency to cross the blood-brain barrier.
Family Members’ Understanding of the End-of-Life Wishes of People Undergoing Maintenance Dialysis
Authors: Saeed Fahad , Butler Catherine R. , Clark Carlyn , O’Loughlin Kristen , Engelberg Ruth A. , Hebert Paul L. , Lavallee Danielle C. , Vig Elizabeth K. , Tamura Manjula Kurella , Curtis J. Randall , O’Hare Ann M. 
Published: September 2021

Background and objectives
People receiving maintenance dialysis must often rely on family members and other close persons to make critical treatment decisions toward the end of life. Contemporary data on family members’ understanding of the end-of-life wishes of members of this population are lacking.

Design, setting, participants, & measurements
Among 172 family members of people undergoing maintenance dialysis, we ascertained their level of involvement in the patient’s care and prior discussions about care preferences. We also compared patient and family member responses to questions about end-of-life care using percentage agreement and the κ-statistic.

Results
The mean (SD) age of the 172 enrolled family members was 55 (±17) years, 136 (79%) were women, and 43 (25%) were Black individuals. Sixty-seven (39%) family members were spouses or partners of enrolled patients. A total of 137 (80%) family members had spoken with the patient about whom they would want to make medical decisions, 108 (63%) had spoken with the patient about their treatment preferences, 47 (27%) had spoken with the patient about stopping dialysis, and 56 (33%) had spoken with the patient about hospice. Agreement between patient and family member responses was highest for the question about whether the patient would want cardiopulmonary resuscitation (percentage agreement 83%, κ=0.31), and was substantially lower for questions about a range of other aspects of end-of-life care, including preference for mechanical ventilation (62%, 0.21), values around life prolongation versus comfort (45%, 0.13), preferred place of death (58%, 0.07), preferred decisional role (54%, 0.15), and prognostic expectations (38%, 0.15).

Conclusions
Most surveyed family members reported they had spoken with the patient about their end-of-life preferences but not about stopping dialysis or hospice. Although family members had a fair understanding of patients’ cardiopulmonary resuscitation preferences, most lacked a detailed understanding of their perspectives on other aspects of end-of-life care.
Kesantunan Berbahasa sebagai Cerminan Karakter Bangsa
Authors: Rahayu Triwati 
Published: September 2021

Prinsip yang berhubungan dengan tatanan yang bersifat sosial, estetika, moral dalam bertindak tutur akan tercermin dalam kesantunan berbahasa. Tata cara berkomunikasi dipengaruhi norma budaya kelompok masyarakat tertentu. Dalam era globalisasi sekarang ini, Indonesia dihadapkan pada kekuatan budaya raksasa yang menjungkirbalikkan norma budaya Indonesia. Hal inilah yang perlu dikembalikan agar diperoleh kearifan yang memadai dalam berkomunikasi. Penerapan prinsip kesantunan, penggunaan honorifik, dan penggunaan eufemisme secara wajar akan membentuk karakter bangsa yang bermartabat.
Participatory Design as a Tool for the Urban Environment Development
Authors: Shcherbina E. Yu. , Klochkova E. R. 
Published: September 2021

Participatory planning is widely used worldwide as a tool of involving citizens in the processes of urban development, and it has also become more popular in Russia. The projects in Russia are implemented using foreign practices of participatory planning, thus there are N theoretical and methodological bases being developed. As a result, the involvement of citizens in the processes of urban development lacks in quality. This paper is devoted to organizing the participatory practices in the design of outdoor areas on the example of Saint Petersburg.the goal of the study is to create unifed rules of organizing participatory planning in Russia.The methodology is based on a systematic approach to the assessment of the outdoor areas quality, evaluation of citizens’ readiness to participate in participatory design and assessment of the availability of the projects implementation in this feld. The assessment of the outdoor areas quality was conducted with a method of a quality rating of a living environment.The evaluation of citizens’ readiness was based on a survey of the territory users. The method of the expert interview was used to assess the availability of the participatory planning projects implementation.The research results are formulated as recommendations for organizing the practices of participatory design in Russia.The following conclusions were made: the implementation of the recommendations provided for organizing the practices of participatory planning would increase the quality of outdoor areas and decrease the number of conﬂicts between stakeholders. Moreover, it would help in creating the local community, where the participants go through the transformation from the passive user to the active designer of the area.
INSTITUIÇÕES DE LONGA PERMANÊNCIA PARA IDOSOS: CONSIDERAÇÕES DO USO DE INSTRUMENTOS DE AVALIAÇÃO PELO PROFISSIONAL TERAPEÛTA OCUPACIONAL
Authors: Varoto Vania Aparecida Gurian , Corsini Tatiana De Vasconcellos Melo 
Published: September 2021

Entre as alternativas para o cuidado não familiar, as Instituições de Longa Permanência para Idosos (ILPI) têm destaque. Diferentes profissionais que podem utilizar instrumentos de avaliação para o favorecimento do cuidado são integrados na rotina das ILPI. Este estudo identificou os terapeutas ocupacionais (TO) atuantes nas ILPI da cidade de São Carlos, os instrumentos que eles utilizam na área da gerontologia e o contexto de sua formação nesta área. Os fundamentos de pesquisa qualitativa, exploratória, descritiva, e de análise de conteúdo foram aplicados, por meio de um questionário semiestruturado sobre as ILPI, o perfil dos TO e sobre os instrumentos que utilizam para avaliar os idosos. Todos os cuidados éticos foram aplicados. Dentre as cinco TO que atuam nas 11 ILPI, todas são mulheres e com mediana de idade de 33 anos. Três delas tem menos de 10 anos de formada e duas entre 19 a 25 anos. Os instrumentos de avaliação são pouco utilizados e conhecidos. Verificou-se que uma TO utiliza alguns instrumentos indicados pelo Ministério da Saúde. Sobre a apropriação de conteúdos de gerontologia, quatro citaram o período da graduação. Há fragilidade de conteúdos na área da gerontologia dos profissionais do estudo, que corrobora com a literatura, entretanto, verificam-se reformulações nos conteúdos de cursos de graduação nesta área.
ANÁLISE DO PERFIL DE ADMISSÃO, EVOLUÇÃO E DESFECHO INTRA-HOSPITALAR DE IDOSOS: COORTE PROSPECTIVA
Authors: Flores Thamara Graziela , Lampert Melissa Agostini , Keller Gabriele Ruiz , De Paula Diogo Oliveira , Alvarenga Erica De Freitas , Dos Santos Tassiane Moreira , Guerra Renata Rojas 
Published: September 2021

O envelhecimento populacional é permeado por uma série de desafios para a saúde pública brasileira, desta forma a avaliação do perfil de idosos em internação hospitalar, considerando presença de comorbidades, parâmetros funcionais e presença de fragilidade tornam-se imprescindível. Dessa forma, busca-se avaliar o perfil de idosos na admissão, evolução hospitalar e desfecho e verificar a associação do perfil da admissão com o desfecho da internação. Trata-se de um estudo de coorte prospectiva. Utilizou-se como variáveis da admissão hospitalar o perfil sociodemográfico e perfil clínico-funcional, como variáveis da evolução, o tempo de internação hospitalar e complicações e como desfecho — alta hospitalar ou óbito. Realizou-se análise descritiva e teste do qui-quadrado ou teste exato de Fisher para associação das variáveis. Foram avaliados 493 idosos, com maioria de idosos jovens, que moravam sozinhos, admitidos no hospital devido a neoplasia. Houve associação positiva do óbito com a idade, Delirium, índice de Comorbidades de Charlson, risco sênior, Fragilidade e valores da circunferência de panturrilha. Verificou-se que a população idosa que ingressa em emergência hospitalar apresenta multimorbidades, declínios funcionais, fragilidade e maior exposição a eventos adversos, entre eles o óbito. Recomenda-se a elaboração de estratégias, para que o cuidado prestado nesse ambiente contemple as peculiaridades desse grupo etário, possibilitando melhores resultados de saúde.
INSTRUMENTOS PARA AVALIAÇÃO DO AMBIENTE DOMICILIAR DO IDOS: UMA REVISÃO SISTEMÂTICAsistemática
Authors: Nepomuceno Aroni Juliana , Correa Ribeiro Pricila Cristina , Do Nascimento Elizabeth 
Published: September 2021

O objetivo deste estudo foi identificar instrumentos utilizados por profissionais e pesquisadores para avaliação do ambiente domiciliar de idosos, bem como descrever propriedades psicométricas e dimensões avaliadas por estes instrumentos e locais da realização dos estudos. Trata-se de uma revisão sistemática da literatura, na qual foram revisados estudos publicados no período de 2006 a 2017, nos idiomas inglês, espanhol e/ou português e que tinham como público-alvo idosos com 60 anos ou mais residentes na comunidade. Foram excluídos estudos que avaliavam, exclusivamente, o ambiente externo, instituições de longa permanência para idosos e os que abordavam questões não gerontológicas. Foram encontrados 1.270 artigos, dos quais 34 foram selecionados para revisão. Verificou-se predomínio do uso de instrumentos padronizados, com evidências de validade e precisão, sendo o Housing Enabler o mais utilizado. Embora haja essa predominância, alguns estudos incluíram instrumentos q ue buscavam a percepção do indivíduo sobre o ambiente. As dimensões mais amplamente avaliadas foram as barreiras ambientais e as adaptações. Conclui-se que instrumentos objetivos para avaliação do ambiente estão sendo produzidos, o que pode facilitar a elaboração de estratégias de monitoramento e de implantação de mudanças no ambiente capazes de interferir positivamente na saúde de idosos. Ressalta-se também a importância de integrar a avaliação dos aspectos objetivos às necessidades subjetivas dos indivíduos em relação ao ambiente.
RAZVOJ VEKTORSKI UPRAVLJANOG POGONA ASINHRONOG MOTORA PRIMENOM MATLAB/SIMULINK AUTOKODING PROCEDURA
Authors: Davidović Zoran , Milićević Dragan 
Published: September 2021

U ovom radu prikazana je mogućnost korišćenja naprednih softverskih alata primenljivih u oblasti elektromotornih pogona. Praktična verifikacija je izvršena na primeru vektorskog upravljanja i na razvijenom prototipu trofaznog invertora. Model je razvijen korišćenjem MATLAB/Simulink paketa tako da je istovremeno postojala mogućnost i softverskih analiza koje su korisne u fazi projektovanja i testiranja sistema uz zadržavanje jednostavnog prelaska na stvarni sistem korišćenjem autokoding podrške. Kao osnovni doprinos rada se mogu prepoznati detaljni eksperimentalni rezultati kojim je dokazana ispravnost usvojenog pristupa u razvoju kontrole.
PROCENA STANјA AB KONSTRUKCIJE I ENERGETSKA SANACIJA ZGRADE BIVŠE MODNE KUĆE "22 DECEMBAR" U ĆUPRIJI
Authors: Stojanović Aleksandar 
Published: September 2021

Rad se sastoji iz dva dela, teorijskog i praktičnog. U teorijskom delu su obrađeni tipovi ventilisanih fasada i fasadni sistemi kompanije „Sobotec“. U praktičnom delu urađena je procena stanja objekta „22. Decembar“ u Ćupriji. Zatim je urađen proračun energetske efikasnosti za postojeće stanje objekta. Nakon predloženih mera enegetske sanacije ponovo je urađen proračun energetske efikasnosti zgrade. Na kraju, upoređeni su rezultati ova dva proračuna.
International experience in providing emergency psychological assistance to minors
Authors: Gavrilova O. Ya. , Ulyanina O. A. 
Published: September 2021

Relevance. The development of a system for providing emergency psychological assistance to minors in our country involves taking into account the leading international experience, both in terms of the practice of providing emergency psychological assistance and at the level of its methodological support.Intention. To review the key aspects of international experience in providing emergency psychological assistance to minors.Methodology. The object of the work was scientific articles indexed in the abstract-bibliographic database of the Russian Science Citation Index, and articles included in international databases.Results and Discussion. There were analyzed the main meta-analytical reviews, as well as data on the implementation of the emergency psychological assistance system in different countries. The article considers such characteristics of emergency psychological assistance as types, terms, place and agents of rendering, as well as the main modalities of psychological practice in which psychological support and assistance to minors is provided. The degree of methodological development of the problem of providing emergency psychological assistance to minors in the international community is revealed through the analysis of two main guidelines with recommendations in relation to working with stress reactions in emergency situations for children and adolescents.Conclusion. The variability of embedding the system for providing emergency psychological assistance both in the structure of the educational sphere and in various departments in different countries makes it possible to reasonably choose the optimal model, taking into account the realities of our country in general and regional characteristics in particular.
Assessment of the working conditions of medical personnel in military medical organizations during the pandemic of new coronavirus infection
Authors: Grebenkov S. V. , Batov V. E. , Kuznetsov S. M. 
Published: September 2021

Relevance. During the pandemic of new coronavirus infection, healthcare professionals have increased occupational risks of exposure to the pathogen SARS-CoV-2, as well as physical and psychological stress, especially when treating Covid patients in “red zones”. Such a change in working conditions wasn’t reflected in the results of a special assessment, which requires the development of an individual scientifically based approach to its organization in conditions equated to emergency situations. Intention. Evaluate the results of a special assessment of working conditions and their compliance with actual working conditions, taking into account the health risks for healthcare professionals taking care of Covid patients.Methodology. We retrospectively conducted a comparative analysis of 295 cards for a special assessment of the working conditions of medical personnel of military medical organizations of therapeutic and infectious profile over 2015–2019, and 266 cards from the same organizations for 2020.Results and Discussion. Study of cards for special assessment of working conditions of medical personnel of military medical organizations for 2015–2020 showed the leading role of biological factors for all categories of medical personnel. Working in the “Red zone” should be assessed as 3.3 (Degree III harmful) based on biological hazard or 4 (dangerous) due to risks of acute occupational diseases and death. This should be reflected in the results of special assessment of working conditions and compensated via reduction of working hours. However, in the context of the pandemic, actual working hours of healthcare professionals exceeded the established 39 hours per week (Article 350 of the Labor Code of the Russian Federation), and the medical personnel were allowed to work with the pathogen of Group II pathogenicity without preliminary medical examinations.Conclusion. Analysis of the results of special assessment of the working conditions of medical personnel showed that they do not reflect the actual harmful (dangerous) working conditions of employees involved in providing care to patients with new coronavirus infection in these medical and preventive institutions.
PEMANFAATAN SABUT PINANG SEBAGAI KOMBINASI LAPISAN MULTI MEDIA-FILTER SABUT PINANG (LMM-FSP) DI PERUMAHAN VALENSIA MUARO JAMBI DAN UJI KUALITAS AIR BERSIH
Authors: Deliza Deliza 
Published: September 2021

Air bersih yang langka di perumahan Valencia Muaro Jambi yang masih dihadapi masyarakat, oleh sebab itu peneliti bertujuan untuk membantu masyarakat perumahan valensia muaro jambi untuk mendapatkan air bersih menggunakan Lapisan Multi Media-Filter Sabut Pinang (LMM-FSP). LMM-FSP merupakan suatu metoda pengolahan air dengan memanfaatkan tanah sebagai media utama yang dibentuk seperti balok bata dan disusun secara selang-seling diantara zeolit. Sistem LMM-FSP terbuat dari galon bekas dicuci bersih tinggi 40 cm berdiameter 28 cm, berisikan blok bata (12x7x4) cm campuran tanah vulkanik, arang, sabut pinang, serbuk besi (70 :10 :10: 5)%, lapisan permiable digunakan zeolit (1-3 mm). Sampel berasal dari sumur warga perumahan valencia, muaro jambi kota jambi. Penelitian dilakukan dengan variasi massa sabut pinang, laju alir 5, 10, 15, 20 mL/menit dan dua cara yaitu aerasi dan non aerasi, diperoleh efisiensi proses aerasi laju alir 5 ml/menit yang paling baik untuk menurunkan kadar pH; Bau; Nitrit; Nitrat; kekeruhan; Mn; Fe pada aerasi yaitu pH 7,5 ; Tidak Berbau; Nitrit 60,30 %, Nitrat 59,33%, Mn 70,10 %, Fe 73,20% dan pada non aerasi pH 7,3 ; Tidak Berbau, Nitrit 50,82%, Nitrat 48,37% Mn 60,91%, Fe 61,20 % Dari semua nilai efisiensi penurunan parameter sudah bisa dikatakan menuhi untuk syarat air bersih[1].
Pemurnian Fikosianin dari Spirulina platensis dengan Metode Liquid Biphasic Flotation (LBF) dan Penentuan Aktivitas Antioksidannya
Authors: Elise Cori Yolanda , Syafrizayanti Syafrizayanti , Salim Marniati 
Published: September 2021

Phycocyanin from Spirulina platensis (S. Platensis) is a pigment-complex protein belong to the light-harvesting phycobiliprotein family. The pigments have high economic value as a natural blue dye as well as the source of antioxidants and anticancer. Production of pure natural phycocyanin remains in high demand. Therefore, this study aimed to obtain phycocyanin with high purity values using modified liquid biphasic flotation (LBF) system and tested for DPPH (1,1-diphenyl-2-pycrilhydrazil) radical scavenging activity. This study produced high purity phycocyanin with purification fold 3.041 ± 0.04 and recovery yields approximately about 70.881%. Purified phycocyanin showed scavenging activity with IC50 of 338.585 mg/mL. Thus, the LBF system yielded high purity phycocyanin pigments.
Laterality and site-specific distribution patterns of Lentigo Maligna and Lentigo Maligna Melanoma
Authors: Brody Gabrielle , Yale Katerina , Nguyen Alora , Juhasz Margit , Doan Linda , Mesinkovska Natasha Atanaskova 
Published: September 2021

Background: Melanoma has been described to have preferential left-sided laterality on the human body. The distribution and invasion patterns of lentigo maligna (LM) and lentigo maligna melanoma (LMM) have not been well described.
Methods: This was a cross-sectional, retrospective study at a single, academic center. LM and LMM cases from 2008-2018 in the dermatopathology registry were analyzed.
Results: A total of 392 cases were included (241 LM and 151 LMM). There was no laterality preference overall. The only exception were neoplasms located on the head/neck, which showed a left-sided laterality. LM and LMM had the highest incidence on the head/neck, followed by upper extremities, trunk, then lower extremities. Men had a higher incidence on the head/neck and trunk, while women had a higher incidence on the extremities. Interestingly, the upper extremities and the right side of the female body had a higher propensity for invasive lesions.
Conclusion: While melanomas demonstrate preferential left-sided laterality, LM and LMM only share this pattern in respect to the head/neck region. Our results complement previous study findings which characterize LM and LMM as a head/neck and upper extremity pathology. Finally, our study suggests that certain body sites and laterality have an increased propensity for invasion.
Idiopathic Aseptic Facial Granuloma
Authors: Garraway Caroline , Huynh Thy , Brodell Robert , Nahar Vinayak K. 
Published: September 2021

Pyodermite froide du visage, otherwise known as idiopathic facial aseptic granuloma (IFAG), is a benign lesion exclusively seen in children and presents as a cold abscess on the face.1 We report a case of a 14-year-old male with IFAG who failed initial treatment with oral doxycycline, but responded to treatment with oral 13-cis-retinoic acid, oral trimethoprim-sulfamethoxazole and intralesional triamcinolone injections over a 7 month period.