bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glutamine supplementation stimulates cell proliferation in skeletal muscle and cultivated myogenic cells of low birth weight piglets
Authors: Zhao Yaolu , Albrecht Elke , Stange Katja , Li Zeyang , Schregel Johannes , Sciascia Quentin L. , Metges Cornelia C. , Maak Steffen 
Published: June 2021

AbstractMuscle growth of low birth weight (LBW) piglets may be improved with adapted nutrition. This study elucidated effects of glutamine (Gln) supplementation on the cellular muscle development of LBW and normal birth weight (NBW) piglets. Male piglets (n = 144) were either supplemented with 1 g Gln/kg body weight or an isonitrogeneous amount of alanine (Ala) between postnatal day 1 and 12 (dpn). Twelve piglets per group were slaughtered at 5, 12 and 26 dpn, one hour after injection with Bromodeoxyuridine (BrdU, 12 mg/kg). Muscle samples were collected and myogenic cells were isolated and cultivated. Expression of muscle growth related genes was quantified with qPCR. Proliferating, BrdU-positive cells in muscle sections were detected with immunohistochemistry indicating different cell types and decreasing proliferation with age. More proliferation was observed in muscle tissue of LBW-GLN than LBW-ALA piglets at 5 dpn, but there was no clear effect of supplementation on related gene expression. Cell culture experiments indicated that Gln could promote cell proliferation in a dose dependent manner, but expression of myogenesis regulatory genes was not altered. Overall, Gln supplementation stimulated cell proliferation in muscle tissue and in vitro in myogenic cell culture, whereas muscle growth regulatory genes were barely altered.
Attitude tracking control for observation spacecraft flying around the target spacecraft
Authors: Su Yunzhe , Yang Yajun , Yang Xuerong , Ye Wei 
Published: June 2021

AbstractThis paper addresses the attitude tracking problem of observation spacecraft, which is traveling around the target spacecraft. To observe the target spacecraft completely, view planning technology is used to select the optimal viewpoints where the observation spacecraft need to achieve and scans the target spacecraft. The desired attitude and desired angular velocity are determined by the relative location and relative velocity of the observation spacecraft with respect to the target spacecraft. The attitude tracking model are globally and uniquely described in the space of . Based on the sliding mode method, a nonlinear feedback controller is designed to track the desired attitude and desired angular velocity. The convergence and stability of the closed‐loop system are assured by Morse‐Lyapunov theorem and LaSalle's theorem. Moreover, it is proved that the attitude error and angular velocity error converge to a tolerable error interval regardless of actuator misalignment, uncertainties of the inertia matrix and external disturbed torque. In addition, the convergence interval is determined by the parameter setting in the controller. Finally, numerical simulations are presented to illustrate the effectiveness of the proposed controller.
Assessment of distributed photovoltaic hosting capacity in integrated electricity and heat systems considering uncertainty
Authors: Zhao Lebing , Wan Can , Yu Peng , Wu Mengjing , Zhao Shen 
Published: June 2021

AbstractDistributed photovoltaics (DPVs) have been widely integrated into power systems due to their abundance, renewability and low cost, while the stochastic nature of DPVs imposes significant influence on the hosting capacity (HC) of DPVs. Here, the integrated electricity and heat system (IEHS) is explored to increase the deployment of DPVs in comparison to the power system by exploiting the interaction between electric and thermal energy. An MILP‐based HC assessment model for DPVs of the IEHS is proposed to efficiently promote the penetration level of DPV generation in distribution networks considering the uncertainty of DPV generation. To reduce the computational burden for HC assessment, the linearisation method combined with the incremental formulations of the big‐M method is developed to simplify the complex non‐linear model of energy devices and networks in IEHS. A scenario‐based uncertainty modelling approach is applied to characterise DPV uncertainty, which improves the accuracy of HC assessment for DPVs. Comprehensive case studies according to a 33‐bus electric network and a 6‐node heat network validate the superiority of the proposed assessment model.
Interpreting dissolved gases in transformer oil: A new method based on the analysis of labelled fault data
Authors: Nanfak Arnaud , Eke Samuel , Kom Charles Hubert , Mouangue Ruben , Fofana Issouf 
Published: June 2021

AbstractIn this contribution, a new dissolved gas analysis (DGA) method combining key gases and ratio approaches for power transformer fault diagnostic is presented. It is based on studying subsets and uses the five main hydrocarbon gases including hydrogen (H2), methane (CH4), ethane (C2H6), ethylene (C2H4), and acetylene (C2H2). The proposed method uses 475 samples from the dataset divided into subsets formed from the maximum and minimum(s) concentrations of the whole dataset. It has been tested on 117 DGA sample data and validated on the International Electrotechnical Commission (IEC) TC10 database. The performance of the proposed diagnostic method was evaluated and compared with the following diagnostic methods: IEC ratios method, Duval's triangle (DT), three ratios technique (TRT), Gouda's triangle (GT), and self‐organizing map (SOM) clusters. The results found were analysed by computer simulations using MATLAB software. The proposed method has a diagnosis accuracy of 97.42% for fault types, as compared to 93.16% of TRT, 96.58% of GT method, 97.25% of SOM clusters method and 98.29% of DT method. However, in terms of fault severity, the proposed method has a diagnostic accuracy of 90.59% as compared to 78.90% of SOM clusters method, 83.76% of TRT, 88.03% of DT method, and 89.74% of GT method.
Pain expression assessment based on a locality and identity aware network
Authors: Xin Xuwu , Li Xiaowu , Yang Shengfu , Lin Xiaoyan , Zheng Xin 
Published: June 2021

AbstractIn clinical medicine, the pain feeling is a significant indicator for the medical condition of patients. Of late, automatic pain assessment methods have received more and more interests. Many researchers proposed corresponding methods and achieved impressive results. However, they always ignore the locality and individual differences of painful expression. Therefore, a locality and identity aware network (LIAN) for pain assessment is presented here. Concretely, for the locality characteristic, a locality aware module consisting of a two‐branch structure, feature and attention branches, is presented. The former learns pain features by a deep network, while the latter guides the pain features to focus on the discriminational regions of pain. As for the individual differences, an identity aware module with a multi‐task method is proposed to represent identity‐related information to achieve identity‐invariant pain assessment. Extensive experiments on public databases show the superiority of LIAN in pain assessment.
RHAPSODIE: Reconstruction of High-contrAst Polarized SOurces and Deconvolution for cIrcumstellar Environments
Authors: Denneulin L. , Langlois M. , Thiébaut É. , Pustelnik N. 
Published: June 2021

Context. Polarimetric imaging is one of the most effective techniques for the high-contrast imaging and characterization of circumstellar environments. These environments can be characterized through direct-imaging polarimetry at near-infrared wavelengths. The Spectro-Polarimetric High-contrast Exoplanet REsearch (SPHERE)/IRDIS instrument, installed on the Very Large Telescope (VLT) in its dual-beam polarimetric imaging mode, offers the capability to acquire polarimetric images at high contrast and high angular resolution. However, dedicated image processing is needed to eliminate the contamination from the stellar light, instrumental polarization effects, and blurring from the instrumental point spread function.
Aims. We aim to reconstruct and deconvolve the near-infrared polarization signal from circumstellar environments.
Methods. We used observations of these environments obtained with the high-contrast imaging infrared polarimeter SPHERE-IRDIS at the VLT. We developed a new way to extract the polarimetric signal using an inverse approach method that benefits from the additional knowledge of the detected signal formation process. The method includes a weighted data fidelity term and smooth penalization, and it takes the instrumental polarization into account.
Results. This method enables us to accurately measure the polarized intensity and angle of linear polarization of circumstellar disks by taking into account the noise statistics and the convolution by the instrumental point spread function. It has the capacity to use incomplete polarimetry cycles, which enhance the sensitivity of the observations. The method improves the overall performances in particular for instances of both low signal-to-noise (S/N) and small polarized flux compared to standard methods.
Conclusions. By increasing the sensitivity and including deconvolution, our method will allow for more accurate studies of these disks morphology, especially in the innermost regions. It also will enable more accurate measurements of the angle of linear polarization at low S/N, which would lead to in-depth studies of dust properties. Finally, the method will enable more accurate measurements of the polarized intensity, which is critical for the construction of scattering phase functions.
Das Einsparpotenzial der Behandlungskosten bei COPD durch Rauchstopp – Modellierung für DMP COPD in Deutschland
Authors: Hering Thomas , Batra Anil , Mühlig Stephan , Nowak Dennis , Rüther Tobias , Schwarzkopf Larissa 
Published: June 2021

ZusammenfassungBasierend auf Real-life-Daten für die Stadien-Verteilung von COPD-Patienten (GOLD) und den faktischen Stadien-bezogenen Behandlungskosten innerhalb einer bundesweiten Kohortenstudie (COSYCONET) 1 wird modellhaft für das Szenario einer Reduktion der Raucher-Quote in dieser Patientengruppe von 26 % um 10 %-Punkte auf 16 % ermittelt, welchen Einfluss die reduzierte Raucher-Quote auf die Behandlungskosten haben dürfte. Zugrunde gelegt wird die Annahme, dass bei herabgesetzter Raucher-Quote leichtere Stadien (I/II) stärker repräsentiert sind, während sich höhere und kostenintensivere Stadien (III/IV) proportional verkleinern. Die Intervention zur Erreichung der Tabakabstinenz wird für die überschlägigen Modell-Berechnungen kalkuliert mit den typischen Kosten einer leitlinienkonformen Behandlung durch Nutzung eines verhaltenstherapeutischen Gruppen-Entwöhnungs-Programmes und der parallel eingesetzten medikamentösen Unterstützung 2 3. Im Ergebnis zeigt sich die mögliche Absenkung der Fallkosten um 10,5 %, wobei reduzierte Kosten bei Komorbiditäten nicht berücksichtigt sind.
Finite Antiviral Therapy in Chronic Hepatitis B Patients with Cirrhosis
Authors: Jeng Wen-Juei , Liaw Yun-Fan 
Published: June 2021

AbstractAntiviral therapy has greatly improved the survival and reduced the incidence of adverse liver events such as hepatic decompensation and hepatocellular carcinoma in chronic hepatitis B patients with cirrhosis (hepatitis B virus [HBV]-cirrhosis). However, hepatitis B surface antigen loss, regarded as the ultimate goal of therapy or functional cure, was rarely achieved during long-term indefinite nucleos(t)ide analogues (Nuc) treatment. Emerging issues such as medication adherence and loss-to-follow-up may lead to increased risk of hepatic decompensation, even catastrophic life-threatening events. Studies have shown that finite therapy is feasible and reasonably safe, even in patients with HBV-cirrhosis. This review critically assesses the scientific evidence of the pros and cons for finite Nuc therapy in HBV-cirrhosis and proposes how to stop Nuc therapy and monitor the off-therapy patients. It also proposes the perspective and unsolved issues to be investigated in the future.
Evaluation of Pathological Findings of COVID-19 by Minimally Invasive Autopsies: A Single Tertiary Care Center Experience from India
Authors: Vishwajeet Vikarn , Purohit Abhishek , Kumar Deepak , Parag Vijay , Tripathi Swapnil , Kanchan Tanuj , Kothari Nikhil , Dutt Naveen , Elhence Poonam Abhay , Bhatia Pradeep Kumar , Nag Vijaya Lakshmi , Garg Mahendra Kumar , Misra Sanjeev 
Published: June 2021

Abstract
Objectives The 2019 novel coronavirus (2019-nCoV) has spread across the globe with more than 6 lakh deaths. Clinical autopsies are important to understand the pathobiology of the disease.
Materials and Methods Autopsy techniques have been modified to be minimally invasive autopsies in all COVID-19 positive cases, and tissue biopsies were sampled from lungs, liver, and bone marrow within an hour after death. Detailed histological analysis was performed in the sampled tissues, along with immunohistochemistry. Patients’ clinical records were collected.
Statistical Analysis Descriptive statistics were used to summarize data.
Results Of the 21 cases studied, 76.2% patients were ≥ 60 years of age, 80.9% were males, and 85.7% had co-morbidities. Histopathological analysis revealed diffuse alveolar damage (including exudative and organizing phase) in 88.9% cases. Microthrombi were seen in 44.4% cases. Additional findings include viral cytopathic changes, metaplastic change in the epithelium, intra-alveolar hemorrhage, and pulmonary edema. Liver showed centrizonal congestion with hepatocytic loss, lobular inflammation, steatosis, Kupffer cell hypertrophy, and sinusoidal neutrophilic infiltration, while significant portal infiltrate and cholestasis were absent to minimal. Bone marrow revealed hemophagocytosis in 60% cases.
Conclusion Incorporation of minimally invasive autopsies provides an effective method to study the pathological findings in COVID-19 deaths in resource-constrained settings. Presence of pulmonary microthrombi in a significant number of cases supports the vascular events, apart from the characteristic diffuse alveolar damage, as an important pathogenic mechanism for lung injury in COVID-19 infections. Histopathological findings in the liver and bone marrow suggest indirect insult to these organs, related to circulatory and/or hyperinflammatory response to viral infections.
Parent-Administered Oral Stimulation in Preterm Infants: A Randomized, Controlled, Open-Label Pilot Study
Authors: Majoli Marta , De Angelis Laura Costanza , Panella Monica , Calevo Maria Grazia , Serveli Simona , Knoll Brenda Lessen , Ramenghi Luca Antonio 
Published: June 2021

Objective The study aimed to assess whether there was any difference in the transition time to full oral feedings between parent-administered and professional-administered premature infant oral motor intervention (PIOMI). The study also evaluated parental satisfaction with performing the intervention through an open-ended questionnaire.
Study Design A single-center, randomized, controlled, open-label pilot study was carried on between March 2017 and May 2019. A total of 39 infants born ≤32 weeks' gestation were randomly assigned to either parent-performed or professionally performed oral stimulation. The oral stimulation was performed once a day for seven consecutive days between 31 and 32 weeks' postmenstrual age.
Results There was no statistically significant difference in transition time, weight gain, or length of hospital stay between the two groups. No adverse events were observed. Parents' satisfaction was high, and their active involvement enhanced their perception of adequacy to care for their infant.
Conclusion Following adequate training, a parent-administered PIOMI may be considered in preterm infants to reduce the transition time to full oral feeding and enhance the direct involvement of parents in neonatal care.
Key Points
The circadian clock gatesDrosophilaadult emergence by controlling the timecourse of metamorphosis
Authors: Mark Brandon , Bustos-González Liliana , Cascallares Guadalupe , Conejera Felipe , Ewer John 
Published: June 2021

SignificanceIn holometabolous insects, the circadian clock restricts the time of adult emergence. Although this daily gating of behavior is one of the first circadian rhythms to be studied, little is known about the mechanism underlying the gating process itself. Here, we show that the circadian clock imposes a daily rhythmicity to the pattern of adult emergence by controlling the timing of the completion of metamorphosis. Thus, our findings reveal that the basis of gating is a developmental process and not an acute on/off activational switch and fundamentally changes our understanding of how this circadian control is accomplished. It also provides evidence of a mechanism by which the circadian clock imposes a daily rhythmicity to behavior through the control of the pace of development.
How both partners’ individual differences, stress, and behavior predict change in relationship satisfaction: Extending the VSA model
Authors: McNulty James K. , Meltzer Andrea L. , Neff Lisa A. , Karney Benjamin R. 
Published: June 2021

Significance
Understanding the factors that explain declines in marital satisfaction is one of the most pressing challenges for relationship science. Yet, several lines of recent research relying on singular theoretical models have questioned our ability to do so. The current research pooled data from 10 independent longitudinal studies of married couples to test a theoretical model that integrates multiple perspectives spanning numerous disciplines. Findings support and extend this model to indicate that both partners’ interpersonal behaviors interact with both partners’ experiences with stress over time to mediate the implications of both partners’ enduring qualities for changes in marital satisfaction. Accordingly, understanding one source of influence on relationships requires acknowledging the independent and interactive effects of the other sources of influence.
Fundamental bounds on the precision of iSCAT, COBRI and dark-field microscopy for 3D localization and mass photometry
Authors: Dong Jonathan , Maestre Dante , Conrad-Billroth Clara , Juffmann Thomas 
Published: June 2021

Abstract
Interferometric imaging is an emerging technique for particle tracking and mass photometry. Mass or position are estimated from weak signals, coherently scattered from nanoparticles or single molecules, and interfered with a co-propagating reference. In this work, we perform a statistical analysis and derive lower bounds on the measurement precision of the parameters of interest from shot-noise limited images. This is done by computing the classical Cramér–Rao bound (CRB) for localization and mass estimation, using a precise vectorial model of interferometric imaging techniques. We then derive fundamental bounds valid for any imaging system, based on the quantum Cramér–Rao formalism. This approach enables a rigorous and quantitative comparison of common techniques such as interferometric scattering microscopy (iSCAT), coherent brightfield microscopy, and dark-field microscopy. In particular, we demonstrate that the light collection geometry in iSCAT greatly increases the axial position sensitivity, and that the Quantum CRB for mass estimation yields a minimum relative estimation error of

σ
m

/

m
=
1

/

(
2

N

)

, where N is the number of collected scattered photons.
Applications of Nijenhuis geometry II: maximal pencils of multi-Hamiltonian structures of hydrodynamic type
Authors: Bolsinov Alexey V , Konyaev Andrey Yu , Matveev Vladimir S 
Published: June 2021

Abstract
We connect two a priori unrelated topics, the theory of geodesically equivalent metrics in differential geometry, and the theory of compatible infinite-dimensional Poisson brackets of hydrodynamic type in mathematical physics. Namely, we prove that a pair of geodesically equivalent metrics such that one is flat produces a pair of such brackets. We construct Casimirs for these brackets and the corresponding commuting flows. There are two ways to produce a large family of compatible Poisson structures from a pair of geodesically equivalent metrics one of which is flat. One of these families is (n + 1)(n + 2)/2 dimensional; we describe it completely and show that it is maximal. Another has dimension ⩽n + 2 and is, in a certain sense, polynomial. We show that a nontrivial polynomial family of compatible Poisson structures of dimension n + 2 is unique and comes from a pair of geodesically equivalent metrics. In addition, we generalize a result of Sinjukov (1961) from constant curvature metrics to arbitrary Einstein metrics.
Conditional variational principles of conditional entropies for amenable group actions
*
Authors: Changrong Zhu 
Published: June 2021

Abstract
Let G be an infinite discrete countable amenable group acting continuously on two compact metrizable spaces X, Y. Assume that φ : (Y, G) → (X, G) is a factor map. Using finite open covers, the conditional topological entropy of φ is defined. The conditional measure-theoretic entropy of φ equals the conditional measure-theoretic entropy of Y to X. With the aid of tiling system of G, the conditional variational principle of φ is studied when (X, G) is an asymptotically h-expansive system. If X = Y and φ is the identity map, the conditional topological entropy of system (X, G) is defined. In the Cartesian square (X × X, G), we define the conditional measure-theoretic entropy of (X, G) to be the defect of the upper semi-continuity of the conditional measure-theoretic entropy of X × X to the first axis. Then the conditional variational principle of (X, G) is obtained.
Symmetry structure of multi-dimensional time-fractional partial differential equations
Authors: Zhang Zhi-Yong , Zheng Jia 
Published: June 2021

Abstract
In this paper, we concentrate on the Lie symmetry structure of a system of multi-dimensional time-fractional partial differential equations (PDEs). Specifically, we first give an explicit prolongation formula involving Riemann–Liouville time-fractional derivative for the Lie infinitesimal generator in multi-dimensional case, and then show that the infinitesimal generator has an elegant structure. Furthermore, we present two simple conditions to determine the infinitesimal generators where one is a system of linear time-fractional PDEs, the other is a system of integer-order PDEs and plays the dominant role in finding the infinitesimal generators. We study three time-fractional PDEs to illustrate the efficiencies of the results.