bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isolated systolic hypertension in young males: a scoping review
Authors: Scott Holly , Barton Matthew J. , Johnston Amy N. B. 
Published: June 2021

AbstractIsolated systolic hypertension typically occurs in young males; however, its clinical significance is unknown. Given the prevalence of the hypertension and its contribution to global morbidity and mortality, a synthesis of the most recent available evidence around isolated systolic hypertension is warranted. This review aims firstly to review the haemodynamic and physical characteristics indicative of cardiovascular risk in young males (aged 18 to 30 years) with isolated systolic hypertension, and secondly to synthesize the associated clinical management recommendations reported in the literature. Six databases were systematically searched for all relevant peer-reviewed literature examining isolated systolic hypertension in young males. Search results were screened and examined for validity, those that did not meet the inclusion criteria were removed. A total of 20 articles were appropriate for inclusion. Key factors indicative of cardiovascular risk in isolated systolic hypertension were characterized by several distinctive haemodynamic parameters and physical characteristics. After the literature was synthesized based around these key factors, two distinct cohorts (healthy and unhealthy) were highlighted. The healthy cohort of younger males with isolated systolic hypertension was associated with a decreased cardiovascular risk and therefore no medical interventions were recommended. The second (unhealthy) cohort was, however, associated with an increased cardiovascular risk and may therefore, benefit from antihypertensive therapy.
Cantil: a previously unreported organ in wild-type Arabidopsis regulated by FT, ERECTA and heterotrimeric G proteins
Authors: Gookin Timothy E. , Assmann Sarah M. 
Published: June 2021

ABSTRACT
We describe a previously unreported macroscopic Arabidopsis organ, the cantil, named for its ‘cantilever’ function of holding the pedicel at a distance from the stem. Cantil development is strongest at the first nodes after the vegetative to reproductive inflorescence transition; cantil magnitude and frequency decrease acropetally. Cantils develop in wild-type Arabidopsis accessions (e.g. Col-0, Ws and Di-G) as a consequence of delayed flowering in short days; cantil formation is observed in long days when flowering is delayed by null mutation of the floral regulator FLOWERING LOCUS T. The receptor-like kinase ERECTA is a global positive regulator of cantil formation; therefore, cantils never form in the Arabidopsis strain Ler. ERECTA functions genetically upstream of heterotrimeric G proteins. Cantil expressivity is repressed by the specific heterotrimeric complex subunits GPA1, AGB1 and AGG3, which also play independent roles: GPA1 suppresses distal spurs at cantil termini, while AGB1 and AGG3 suppress ectopic epidermal rippling. These G protein mutant traits are recapitulated in long-day flowering gpa1-3 ft-10 plants, demonstrating that cantils, spurs and ectopic rippling occur as a function of delayed phase transition, rather than as a function of photoperiod per se.
Paternal MTHFR deficiency leads to hypomethylation of young retrotransposons and reproductive decline across two successive generations
Authors: Karahan Gurbet , Chan Donovan , Shirane Kenjiro , McClatchie Taylor , Janssen Sanne , Baltz Jay M. , Lorincz Matthew , Trasler Jacquetta 
Published: June 2021

ABSTRACT
5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in the folate metabolic pathway with a key role in generating methyl groups. As MTHFR deficiency impacts male fertility and sperm DNA methylation, there is the potential for epimutations to be passed to the next generation. Here, we assessed whether the impact of MTHFR deficiency on testis morphology and sperm DNA methylation is exacerbated across generations in mouse. Although MTHFR deficiency in F1 fathers has only minor effects on sperm counts and testis weights and histology, F2 generation sons show further deterioration in reproductive parameters. Extensive loss of DNA methylation is observed in both F1 and F2 sperm, with &gt;80% of sites shared between generations, suggestive of regions consistently susceptible to MTHFR deficiency. These regions are generally methylated during late embryonic germ cell development and are enriched in young retrotransposons. As retrotransposons are resistant to reprogramming of DNA methylation in embryonic germ cells, their hypomethylated state in the sperm of F1 males could contribute to the worsening reproductive phenotype observed in F2 MTHFR-deficient males, compatible with the intergenerational passage of epimutations.
Η θεραπευτική σχέση στην κλινική και συμβουλευτική ψυχολογία
Authors: Kalantzi-Azizi Anastasia , Malikiosi-Loizos Maria 
Published: June 2021

The introductory article of this special issue presents the therapeutic relationship in clinical and counseling psychology in order to highlight their similarities and their differences. Initially, reference is made to the particular characteristics of the therapeutic relationship from the point of view of clinical psychology followed by the specific characteristics of the therapeutic relationship as supported by counseling psychology. As can be seen from the position taken by both authors, recent developments in both applied fields show a gradual convergence in terms of the psychotherapy followed. Although at the beginning their differences seemed very obvious, through the years and their historical development, they have gradually faded away, allowing their similarities to stand out based on the philosophical movements, their theoretical views and their scientific interventions. The convergence of clinical and counseling psychology, in terms of the factors building the therapeutic relationship, emphasize their mutual acceptance of concepts, goals and processes.
Covid-19 in end-stage renal disease patients with renal replacement therapies: A systematic review and meta-analysis
Authors: Nopsopon Tanawin , Kittrakulrat Jathurong , Takkavatakarn Kullaya , Eiamsitrakoon Thanee , Kanjanabuch Talerngsak , Pongpirul Krit 
Published: June 2021

BackgroundThe novel coronavirus (COVID-19), caused by SARS-CoV-2, showed various prevalence and case-fatality rates (CFR) among patients with different pre-existing chronic conditions. End-stage renal disease (ESRD) patients with renal replacement therapy (RRT) might have a higher prevalence and CFR due to reduced immune function from uremia and kidney tropism of SARS-CoV-2, but there was a lack of systematic study on the infection and mortality of the SARS-CoV-2 infection in ESRD patients with various RRT.Methodology/Principal findingsWe searched five electronic databases and performed a systematic review and meta-analysis up to June 30, 2020, to evaluate the prevalence and case fatality rate (CFR) of the COVID-19 infection among ESRD patients with RRT. The global COVID-19 data were retrieved from the international database on June 30, 2020, for estimating the prevalence and CFR of the general population as referencing points. Of 3,272 potential studies, 34 were eligible studies consisted of 1,944 COVID-19 confirmed cases in 21,873 ESRD patients with RRT from 12 countries in four WHO regions. The overall pooled prevalence in ESRD patients with RRT was 3.10% [95% confidence interval (CI) 1.25–5.72] which was higher than referencing 0.14% global average prevalence. The overall estimated CFR of COVID-19 in ESRD patients with RRT was 18.06% (95% CI 14.09–22.32) which was higher than the global average at 4.98%.ConclusionsThis meta-analysis suggested high COVID-19 prevalence and CFR in ESRD patients with RRT. ESRD patients with RRT should have their specific protocol of COVID-19 prevention and treatment to mitigate excess cases and deaths.
Integrative Neuromuscular Training Enhances Physical Fitness in 6- to 14-Year-Old Rugby Players
Authors: Alonso-Aubin Diego A. , Picón-Martínez Moisés , Rebullido Tamara R. , Faigenbaum Avery D. , Cortell-Tormo Juan M. , Chulvi-Medrano Iván 
Published: June 2021

Abstract
Alonso-Aubin, DA, Picón-Martínez, M, Rebullido, TR, Faigenbaum, AD, Cortell-Tormo, JM, and Chulvi-Medrano, I. Integrative neuromuscular training enhances physical fitness in 6- to 14-year-old rugby players. J Strength Cond Res 35(8): 2263–2271, 2021—The purpose of this study was to assess the effects of an 8-week integrative neuromuscular training (INT) program on physical fitness measures in young rugby players. A sample of 138 male rugby players (age range, 6–14 years) was divided into 5 age-related groups: group 1 (G1) (n = 20; age, 7.05 ± 0.58), group 2 (G2) (n = 27; age, 8.57 ± 0.49), group 3 (G3) (n = 31; age, 11.02 ± 0.56), group 4 (G4) (n = 33; age, 13.12 ± 0.58, and group 5 (G5) (n = 27; age, 14.85 ± 1.53 and additionally into 2 game position groups: forwards (FOR) (n = 69) and backs (BAC) (n = 69). Physical fitness measures included the Functional Movement Screen (FMS), dominant and nondominant hand-to-eye coordination, sprint capacity, core muscular endurance, and lower- and upper-body power. Integrative neuromuscular training (INT) included progressive strength, coordination, and speed exercises performed twice per week for 20 minutes. Following INT, significant improvements in selected age-related groups (p < 0.01) were found in total FMS score G3 (effect size [ES] = 0.47), G4 (ES = 0.88), and G5 (ES = 0.58); dominant hand-to-eye coordination G1 (ES = 1.48), G2 (ES = 0.71), G3 (ES = 0.55), G4 (ES = 1.47), and G5 (ES = 1.15), nondominant hand-to-eye coordination G2 (ES = 0.74), G4 (ES = 1.34), and G5 (ES = 1.09); lower-body power G2 (ES = 0.44), G4 (ES = 0.39), and G5 (ES = 0.43); core muscular endurance G1 (ES = 0.82), G3 (ES = 0.68), and G4 (ES = 1.04); upper-body power G2 (ES = 0.53); and sprint capacity G4 (ES = 0.69). Significant improvements were also found between player's positions for all tests. These findings indicate that a progressive INT program can enhance functional movement abilities and selected physical fitness measures in young rugby players regardless of game position and age.
Accelerated UV Aging of a Wax-Based Binder Used in Synthetic Granular Composite Equine Sports Surfaces
Authors: Bridge John W. , Yeung Cham Hang , Dempsey Kaleb M. , Yoshizumi Devin A. , Weisshaupt Kristofer S. 
Published: June 2021

Abstract
A series of controlled ultraviolet (UV) exposure tests were conducted on a virgin high-oil content, paraffin-based wax binder used in an operational US Thoroughbred horse racetrack to simulate multiyear outside exposure. This type of hydrocarbon binder is commonly used in synthetic granular composite surfaces used in North American Thoroughbred horse racetracks and other equine sports surfaces. The binder coats the sand, fiber, and rubber particulate that make up the surface. Previous research on this binder, extracted yearly from the same racetrack over a six-year period, showed that environmental oxidation increased steadily (no material was added to the surface during this period). Chemical and compositional changes to the binder have been shown to affect the mechanical performance of the overall surface, which may impact the safety of both horse and jockey/rider. The results of this study demonstrate that two days of accelerated aging in the laboratory using a UV-modified convective furnace generates binder oxidation consistent with six years of natural environmental exposure. The increase in oxidation over time, determined using the 1,700 cm−1 carbonyl absorption peak in the infrared absorption spectrum, was found to be linear in nature, thus giving a practical method to correlate aging over time with other synthetic racetrack surfaces and associated wax-based binders. Results were substantiated by Fourier transform infrared spectroscopy, with supporting data from differential scanning calorimetry, and gas chromatography–flame ionization detection.
Obituario. Mario Arrubla Yepes
Authors: Jaramillo Restrepo Sandra 
Published: June 2021

El 7 de diciembre de 2020, cuando finalizaba el primer año de la pandemia, falleció Mario Arrubla Yepes en Goshen, Massachusetts, Estados Unidos. Intelectual, escritor y editor de relevancia nacional, Arrubla fue ampliamente influyente en la generación que desde la década de 1960 hacía foco en el cambio social y debatía sobre las vías “revolucionarias o reformistas” y sus más polisémicos contenidos.
Nacido en Medellín el 14 de mayo de 1936, Arrubla provenía de una familia antioqueña trabajadora que había hecho parte del proceso de transición del campo a la incipiente urbe a inicios del siglo XX. Desarrolló una atracción temprana por los libros, haciendo de la lectura y la escritura prácticas cotidianas. Hizo sus estudios primarios en la Escuela Alfonso López del barrio Manrique y para la secundaria pasó al Liceo de la Universidad de Antioquia, retirándose en tercer año de bachillerato (1952) en pro de emprender una formación intelectual autónoma junto con otro intelectual antioqueño: Estanislao Zuleta (1935-1990). Durante varios años este fue su colega y amigo con quien compartió la formación intelectual y la práctica política iniciales. Al momento del retiro de la escuela, la poesía y la literatura moderna fueron objeto de atención. Tiempo después, ambos se ocuparon del existencialismo, el marxismo y el psicoanálisis.
Edición y frustración. El fracaso de la colección Poetas Hispano-Americanos y los límites del comercio de librería en América Latina a fines del siglo XIX
Authors: Murillo Sandoval Juan David 
Published: June 2021

Objetivo: este artículo analiza el inicio, desarrollo y fracaso de la colección Poetas Hispano-Americanos, un ambicioso proyecto editorial concebido por el librero colombiano Lázaro María Pérez en 1887. A pesar de contar con el establecimiento mejor surtido y conectado de su época, el lento y dificultoso avance de este proyecto, del que logró publicar apenas un tomo, permite examinar los problemas que debían encarar los editores suramericanos para trabajar a escala continental, así como la relación no estricta entre una red de contactos transnacional y el éxito comercial. Metodología: las cartas del archivo familiar de Pérez, que revelan sus intercambios internacionales, así como su correspondencia con el bibliotecario peruano Ricardo Palma, permiten reconstruir tanto el empuje inicial del proyecto, como su estancamiento, y constituyen fuentes de relevancia para analizar las prácticas intelectuales y editoriales del librero. Originalidad: al igual que ocurre con otros itinerarios de su tipo, el de Lázaro María Pérez resulta desconocido, por lo que su reconstrucción y el análisis de este megaproyecto editorial resultan claves para examinar las dinámicas del comercio del libro en Colombia y los dominios y horizontes de sus representantes para finales del siglo XIX. Conclusiones: desde las orillas de la historia transnacional del libro, el artículo subraya, por un lado, las capacidades de Pérez como librero y editor, gracias a las cuales pudo convertirse, al menos temporalmente, en un agente del libro clave en el espacio cultural latinoamericano, y por otro, enfatiza la necesidad de atender las conexiones como elementos significativos en la construcción del mercado del libro continental, pero asimismo como mediadoras no necesariamente efectivas.
Determinants of disease acceptance in renal transplantation patients assessed with the application of Acceptance Illness Scale (AIS)
Authors: Fedorowicz Olga , Jaźwińska-Tarnawska Ewa , Adamiszak Arkadiusz , Niewiński Przemysław , Krajewska Magdalena , Wiela-Hojeńska Anna 
Published: June 2021

Purpose: Kidney transplant patients require long-term pharmacotherapy with a significant risk of drug-related complications. The disease acceptance may significantly affect the effectiveness, safety, and patient adherence to their treatment. The purpose of this study was to evaluate, for kidney transplantation patients, the essential determinants for better disease acceptance, and whether a clinical pharmacist may influence its degree. Methods: The study involved 201 renal graft patients aged 18-81 years. The diagnostic survey method with the questionnaire of the Acceptance Illness Scale (AIS) and authors' query was used to obtain sociodemographic and co-morbidities data, the number of medications taken, the therapy cost, a patient needs for more attention from medical staff, and their willingness to cooperate with a clinical pharmacist. Results: The largest group (55.2%) of patients demonstrated a high level of acceptance of their health. However, in every disease acceptance score range (low, medium, high), the score was statistically lower in patients over 50 years of age (c2=7.27, p=0.026), occupationally inactive (c2 =13.8, p<0.001), over 5 medicines taken (c2=7.77, p=0.020), and declaring too much expenditure on the therapy (c2=14.3, p<0.001). The assessment established a statistically significant negative correlation between the number of chronic conditions and the AIS score (R=-0.32, p<0.001). The lower number of coexisting chronic diseases the better disease acceptance. Moreover, patients reporting the need for more attention from the health service and willing to consult a pharmacist cope in a statistically significant way worse with accepting their health (c2=15.1 and p<0.001, c2=6.76 and p=0.034 respectively). Conclusion: For post-transplantation patients, factors affecting the acceptance of illness should be taken into consideration while planning medical care. The reported need for professional assistance indicates necessity for establishing a multidisciplinary therapeutic team in which a clinical pharmacist should play a special role.
Badania porównawcze liniowych ładunków kumulacyjnych
Authors:   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Habera Łukasz , Hebda Kamil ,   Instytut Nafty i Gazu – Państwowy Instytut Badawczy
Published: June 2021

The fireground tests are the best method for verifying the operation effectiveness of the entire shooting device or its component parts in real conditions. The purpose of the fireground tests presented herein was the physical verification of linear shaped charge (LSC) ability to perforate multi-layered target, reflecting the material and geometrical conditions of a borehole. The series of shooting tests included tests of three types of linear shaped charges selected for use in perfo-fracturing devices. The following shaped charges were tested: LSC in lead enclosure, having φ = 40 mm circular cross-section with shaped recess; LSC with copper liner in 20/30 mm steel trapezoid enclosure; LSC with liner made of solid copper, in 20/40 mm steel trapezoidal enclosure.During testing, the cumulative jet velocity was recorded using voltage type probes, arranged between the individual layers of a target composed of steel and concrete materials. The research method adapted for the project purposes was aimed at verification of the following thesis: whether the proposed shaped charges fulfil the technical and performance conditions for their effective application in the oil industry. The criterion adopted was the ability – or lack of ability – to perforate the multi-layered barrier in the form of two steel plates and concrete casting. The testing stand, single-use by its nature, was each time composed of concrete block having 400 mm ´ 250 mm ´ 150 mm dimensions and 20 MPa static compressive strength, on which two steel plates were placed parallel to each other with 20 mm spacing. The thickness of the plates was 5 mm and 10 mm respectively. The tested shaped charge was placed on the top steel plate at a distance of one calibre – that is the distance equal to the opening of the trapezoidal shaped charge and full diameter of circular cross-section charge. Furthermore, within media interface planes (steel/air, air/steel; steel/concrete), the set of voltage-type measuring probes was installed, in the form of single electric wires (φ = 0.25 mm). At an instant when they break (circuit break) as a result of cumulative jet operation, voltage drop in the subsequent measuring probes will act as a logical gate of start-stop type, or in other words the zero-one (0–1) type gate. The readings of individual probes breakage times allowed in addition to determine the velocity of the cumulative jet and to estimate its braking dynamics while passing through the subsequent elements of multi-layered target.
Use of a Tourniquet and Spinal Anesthesia Increases Satisfactory Outcomes After Total Knee Arthroplasty
Authors: Rantasalo Mikko , Palanne Riku , Vakkuri Anne , Olkkola Klaus T. , Madanat Rami , Skants Noora 
Published: June 2021

Background:
Total knee arthroplasty (TKA) is usually performed successfully with or without a tourniquet and under spinal anesthesia (SA) or general anesthesia (GA). However, 10% to 34% of patients experience dissatisfaction and pain after TKA. We aimed to compare the effects of tourniquet use and SA or GA on TKA outcomes.

Methods:
We randomly assigned 404 patients to 4 study groups: SA without a tourniquet (NT/SA), SA with a tourniquet (T/SA), GA without a tourniquet (NT/GA), and GA with a tourniquet (T/GA). The primary outcome was the change in the Oxford Knee Score (OKS) at 1 year postoperatively. Secondary outcomes included a satisfactory TKA outcome assessed using the OKS minimal important change (MIC) and OKS patient acceptable symptom state (PASS), adverse events, and quality of life using the 15-dimensional health-related quality of life tool.

Results:
At 1 year, the OKS was obtained for 381 patients. In the 2-group comparisons, the tourniquet did not affect the OKS improvement. The SA group had more substantial improvement in the OKS than the GA group (16.21 compared with 14.08 a mean difference of 2.13; 95% confidence interval [CI], 0.55 to 3.71; p = 0.008). In the 4-group comparisons, the T/SA group had more substantial improvements in the OKS than the NT/GA group (16.87 compared with 13.65, a mean difference of 3.2; 95% CI, 0.28 to 6.17; p = 0.026). The SA group reached the OKS MIC more frequently than the GA group (91.7% compared with 81.7%; odds ratio [OR] = 2.49 [95% CI, 1.32 to 4.69]; p = 0.005). The SA group also reached the OKS PASS more frequently than the GA group (86.0% compared with 75.7%; OR = 2.00 [95% CI, 1.18 to 3.39]; p = 0.010). The T/SA group had significantly more patients reaching the OKS MIC than the NT/GA group (95.7% compared with 79.6%; p = 0.005) and more patients reaching the OKS PASS than the NT/GA group (92.6% compared with 74.5%; p = 0.004). No differences were seen with respect to adverse events in any comparisons.

Conclusions:
The tourniquet had no detrimental effects on the outcomes of TKA. SA had a positive effect on the OKS. The use of SA combined with a tourniquet resulted in the best improvement in OKS and the highest proportion of satisfactory outcomes with TKA.

Level of Evidence:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Industrialization, Servicification And Environmental Kuznets Curve: Non-Linear Panel Regression Analysis
Authors: Taşdemir Fatma 
Published: June 2021

Abstract
This paper investigates whether the impact of income on CO2 emissions is invariant to endogenously estimated threshold levels for the economic structure (ES) represented by value added in manufacturing, industry and services sector shares in GDP for a panel of 54 economies over the 1971–2017 period. Our panel smooth transition regression estimation results strongly suggest that the sensitivity of CO2 emissions to income is substantially much higher in countries with higher manufacturing and industry sector shares whilst it is much lower in servicified economies. Given the argument that manufacturing is the engine of growth, this finding may not necessarily downgrade the crucial importance of an industrial policy which places the manufacturing at the core. The empirical findings in this paper suggest that countries may better to design and implement a strategic and systematic industrial policy which promote the use of emission reduction technologies and encourage manufacturing and industrial sectors with lower carbon emissions.