bluuebunny/crossref_metadata_2025_split huggingface dataset:
Armellinoite-(Ce), Ca4Ce4+(AsO4)4⋅H2O, a new mineral species isostructural with pottsite, (Pb3Bi)Bi(VO4)4⋅H2O
Authors: Cámara Fernando , Ciriotti Marco E. , Kolitsch Uwe , Bosi Ferdinando , Bittarello Erica , Brizio Piero , Vignola Pietro , Blaß Günter 
Published: December 2021

AbstractArmellinoite-(Ce), ideally Ca4Ce4+(AsO4)4⋅H2O, is a new mineral discovered in Fe–Mn ore in metaquartzites of the Montaldo mine, Corsaglia Valley, Cuneo Province, Piedmont, Italy. It occurs as very small and rare, pale yellow to brown–yellow pseudo-octahedral translucent crystals hosted by a matrix of quartz, hematite, cryptomelane/hollandite, tilasite, muscovite, braunite and montmorillonite. The mineral is translucent, with white streak and has a resinous to vitreous lustre. It is brittle with irregular fracture and fair cleavage parallel to {110} and {100}. Estimated Mohs hardness is ~3–3.5. Calculated density is 4.29 g⋅cm–3. Armellinote-(Ce) is uniaxial (–), ω = 1.795(5), ɛ = 1.765(5) (white light), non-pleochroic and non-fluorescent. Chemical point analyses by WDS-EPMA yielded the empirical formula (based on 17 O+F anions): A(Ca3.89Th0.08Sr0.02La0.03)Σ4.02B(Ce4+0.76Nd0.13Y0.08Gd0.03Sm0.02Pr0.01Dy0.01Ho0.01)Σ1.05[(As4.00P0.01)Σ4.01O4]4⋅(H2O0.85F0.15)Σ2.00. The presence of H2O was confirmed by Raman spectroscopy. The mineral is tetragonal, I41/a, with single-crystal unit-cell parameters a = 10.749(2), c = 12.030(2) Å and V = 1390.0(6) Å3, with Z = 4. The eight strongest X-ray powder diffraction lines are [d Å (Irel; hkl)]: 7.983 (36; 101), 4.443 (23; 2̄11), 2.957 (100; 3̄12), 2.398 (14; 420), 1.875 (22; 424, 325), 1.728 (19; 3̄16), 1.612 (13; 613) and 1.475 (26; 712, 552). The crystal structure (R1 = 0.0284 for 1275 unique reflections) has isolated TO4 (T = As5+) tetrahedra that link Ca2+- or Ce4+-centred polyhedra via common oxygen ligands to form 2D blocks or double-layered (DL) structural units parallel to (001). Armellinoite-(Ce) is isostructural with pottsite, ideally (Pb3Bi)Bi(VO4)4⋅H2O, and closely related to a larger number of anhydrous synthetic compounds. The mineral is named after the mineral collector Gianluca Armellino (b. 1962), who collected the discovery sample.
Light-activated Multilevel Resistive Switching Storage in Pt/Cs2AgBiBr6/ITO/Glass Devices
Authors: Zhong Tingting , Qin Yongfu , Lv Fengzhen , Qin Haijun , Tian Xuedong 
Published: December 2021

Abstract
High-density Cs2AgBiBr6 films with uniform grains were prepared by a simple one-step and low-temperature sol–gel method on indium tin oxide (ITO) substrates. An explicit tristate bipolar resistance switching behavior was observed in the Pt/Cs2 AgBiBr6/ITO/glass devices under irradiation of 10 mW/cm2 (445 nm). This behavior was stable over 1200 s. The maximum ratio of the high and low resistance states was about 500. Based on the analysis of electric properties, valence variation and absorption spectra, the resistive switching characteristics were attributed to the trap-controlled space charge-limited current mechanism due to the bromine vacancies in the Cs2AgBiBr6 layer. On the other hand, it is suggested that the ordering of the Schottky-like barrier located at Pt/Cs2AgBiBr6 affects the three-state resistance switching behavior under light irradiation. The ability to adjust the photoelectrical properties of Cs2AgBiBr6-based resistive switching memory devices is a promising strategy to develop high-density memory.

Graphical Abstract
Putative antigenic proteins identified by comparative and subtractive reverse vaccinology in necrotic enteritis-causing Clostridium perfringens isolated from broiler chickens
Authors: Meniaï Ilhem , Thibodeau Alexandre , Quessy Sylvain , Parreira Valeria R. , Fravalo Philippe , Beauchamp Guy , Gaucher Marie-Lou 
Published: December 2021

Abstract
Background
Avian necrotic enteritis (NE) caused by Clostridium perfringens is a disease with a major economic impact, generating losses estimated to 6 billion of dollars annually for the poultry industry worldwide. The incidence of the disease is particularly on the rise in broiler chicken flocks eliminating the preventive use of antibiotics. To date, no alternative allows for the efficient prevention of NE and a control of the disease using a vaccinal strategy would be mostly prized. For this purpose, comparative and subtractive reverse vaccinology identifying putative immunogenic bacterial surface proteins is one of the most promising approaches.

Results
A comparative genomic study was performed on 16 C. perfringens strains isolated from healthy broiler chickens and from broilers affected with necrotic enteritis. Results showed that the analyzed genomes were composed of 155,700 distinct proteins from which 13% were identified as extracellular, 65% as cytoplasmic and 22% as part of the bacterial membrane. The evaluation of the immunogenicity of these proteins was determined using the prediction software VaxiJen®.

Conclusions
For the most part, proteins with the highest scores were associated with an extracellular localisation. For all the proteins analyzed, the combination of both the immunogenicity score and the localisation prediction led to the selection of 12 candidate proteins that were mostly annotated as hypothetical proteins. We describe 6 potential candidates of higher interest due to their antigenic potential, their extracellular localisation, and their possible role in virulence of C. perfringens.
Proteome and secretome profiling of zinc availability in Cryptococcus neoformans identifies Wos2 as a subtle influencer of fungal virulence determinants
Authors: Ball B. , Woroszchuk E. , Sukumaran A. , West H. , Afaq A. , Carruthers-Lay D. , Muselius B. , Gee L. , Langille M. , Pladwig S. , Kazi S. , Hendriks A. , Geddes-McAlister J. 
Published: December 2021

AbstractBackgroundFungal infections impact over 25% of the global population. For the opportunistic fungal pathogen,Cryptococcus neoformans, infection leads to cryptococcosis. In the presence of the host, disease is enabled by elaboration of sophisticated virulence determinants, including polysaccharide capsule, melanin, thermotolerance, and extracellular enzymes. Conversely, the host protects itself from fungal invasion by regulating and sequestering transition metals (e.g., iron, zinc, copper) important for microbial growth and survival.ResultsHere, we explore the intricate relationship between zinc availability and fungal virulence via mass spectrometry-based quantitative proteomics. We observe a core proteome along with a distinct zinc-regulated protein-level signature demonstrating a shift away from transport and ion binding under zinc-replete conditions towards transcription and metal acquisition under zinc-limited conditions. In addition, we revealed a novel connection among zinc availability, thermotolerance, as well as capsule and melanin production through the detection of a Wos2 ortholog in the secretome under replete conditions.ConclusionsOverall, we provide new biological insight into cellular remodeling at the protein level ofC. neoformansunder regulated zinc conditions and uncover a novel connection between zinc homeostasis and fungal virulence determinants.
Effects of various artificial agarwood-induction techniques on the metabolome of Aquilaria sinensis
Authors: Zhang Ningnan , Xue Shiyu , Song Jie , Zhou Xiuren , Zhou Dahao , Liu Xiaojin , Hong Zhou , Xu Daping 
Published: December 2021

Abstract
Background
Agarwood is a highly sought-after resinous wood for uses in medicine, incense, and perfume production. To overcome challenges associated with agarwood production in Aquilaria sinensis, several artificial agarwood-induction treatments have been developed. However, the effects of these techniques on the metabolome of the treated wood samples are unknown. Therefore, the present study was conducted to evaluate the effects of four treatments: fire drill treatment (F), fire drill + brine treatment (FS), cold drill treatment (D) and cold drill + brine treatment (DS)) on ethanol-extracted oil content and metabolome profiles of treated wood samples from A. sinensis.

Results
The ethanol-extracted oil content obtained from the four treatments differed significantly (F < D < DS < FS). A total of 712 metabolites composed mostly of alkaloids, amino acids and derivatives, flavonoids, lipids, phenolic acids, organic acids, nucleotides and derivatives, and terpenoids were detected. In pairwise comparisons, 302, 155, 271 and 363 differentially accumulated metabolites (DAM) were detected in F_vs_FS, D_vs_DS, F_vs_D and FS_vs_DS, respectively. The DAMs were enriched in flavonoid/flavone and flavonol biosynthesis, sesquiterpenoid and triterpenoid biosynthesis. Generally, addition of brine to either fire or cold drill treatments reduced the abundance of most of the metabolites.

Conclusion
The results from this study offer valuable insights into synthetically-induced agarwood production in A. sinensis.
Preparation of Dräger Atlan A350 and General Electric Healthcare Carestation 650 anesthesia workstations for malignant hyperthermia susceptible patients
Authors: Heiderich Sebastian , Thoben Christian , Dennhardt Nils , Krauß Terence , Sümpelmann Robert , Zimmermann Stefan , Reitz Michael , Rüffert Henrik 
Published: December 2021

Abstract
Background
Patients at risk of malignant hyperthermia need trigger-free anesthesia. Therefore, anesthesia machines prepared for safe use in predisposed patients should be free of volatile anesthetics. The washout time depends on the composition of rubber and plastic in the anesthesia machine. Therefore, new anesthesia machines should be evaluated regarding the safe preparation for trigger-free anesthesia. This study investigates wash out procedures of volatile anesthetics for two new anesthetic workstations: Dräger Atlan A350 and General Electric Healthcare (GE) Carestation 650 and compare it with preparation using activated charcoal filters (ACF).

Methods
A Dräger Atlan and a Carestation 650 were contaminated with 4% sevoflurane for 90 min. The machines were decontaminated with method (M1): using ACF, method 2 (M2): a wash out method that included exchange of internal parts, breathing circuits and soda lime canister followed by ventilating a test lung using a preliminary protocol provided by Dräger or method 3 (M3): a universal wash out instruction of GE, method 4 (M4): M3 plus exchange of breathing system and bellows. Decontamination was followed by a simulated trigger-free ventilation. All experiments were repeated with 8% desflurane contaminated machines. Volatile anesthetics were detected with a closed gas loop high-resolution ion mobility spectrometer with gas chromatographic pre-separation attached to the bacterial filter of the breathing circuits. Primary outcome was time until < 5 ppm of volatile anesthetics and total preparation time.

Results
Time to < 5 ppm for the Atlan was 17 min (desflurane) and 50 min (sevoflurane), wash out continued for a total of 60 min according to protocol resulting in a total preparation time of 96-122 min. The Carestation needed 66 min (desflurane) and 24 min (sevoflurane) which could be abbreviated to 24 min (desflurane) if breathing system and bellows were changed. Total preparation time was 30-73 min. When using active charcoal filters time to < 5 ppm was 0 min for both machines, and total preparation time < 5 min.

Conclusion
Both wash out protocols resulted in a significant reduction of trace gas concentrations. However, due to the complexity of the protocols and prolonged total preparation time, feasibility in clinical practice remains questionable. Especially when time is limited preparation of the anesthetic machines using ACF remain superior.
Ligation-assisted endoscopic mucosal resection has high complete resection rate in rectal carcinoid tumor
Authors: Su Ming-Yao , Chiu Cheng-Tang 
Published: December 2021

Abstract
Aim
We aimed to compare the outcomes of different therapeutic modalities in rectal carcinoid tumors.

Method
We retrospectively collected 145 patients with rectal carcinoid tumors which were pathologically diagnosed from 2005/01/01 to 2016/12/31. We compared tumor size, complete resection rate and recurrent rate between different therapeutic modalities. Then, prospectively compared the treatment outcomes of 28 patients treated with ligation assisted endoscopic mucosal resection (LEMR) and 25 patients treated with endoscopic mucosal resection with cap (EMRC).

Result
The mean size of tumors was 6.5 mm (1–25 mm), and the mean follow-up duration was 26 months (6–118 months). The therapeutic modalities included ligation-assisted endoscopic mucosal resection (LEMR) (25 tumors, 17%), endoscopic mucosal resection (EMR) (31 tumors, 21%), snare polypectomy (30 tumors, 21%), biopsy forceps removal (46 tumors, 32%) and surgical resection (13 tumors, 11%), including 6 tumors treated with transanal endoscopic microsurgery (TEM) method. In view of pathologically complete resection rate, LEMR was highest (100%), followed by surgical resection (85%). However, EMR only had 42% pathologically complete resection rate. Besides, LEMR and surgical resection had no local recurrence and significantly higher clinically complete resection rate, compared to other treatments. For the further prospective study, complete resection was noted in 28 (100%) patients in LEMR group and 13 (52%) patients in EMRC group.

Conclusion
In the treatment of rectal carcinoid tumors, LEMR is safe and effective compared with traditional endoscopic treatments.
Lived experiences of Ugandan women who had recovered from a clinical diagnosis of postpartum depression: a phenomenological study
Authors: Atuhaire Catherine , Rukundo Godfrey Zari , Brennaman Laura , Cumber Samuel Nambile , Nambozi Grace 
Published: December 2021

Abstract
Background
Postpartum depression affects a significant proportion of women of childbearing age. The birth of a newborn baby is normally considered a joyful event, inhibiting mothers from expressing their depressive feelings. If the condition is not well understood and managed, mothers with postpartum depression are likely to experience suicidal ideation or even commit suicide. This study explored lived experiences of women who had recovered from a clinical diagnosis of postpartum depression in southwestern Uganda.

Methods
This phenomenological study adopted the explorative approach through in-depth interviews as guided by the biopsychosocial model of depression. It was conducted in Mbarara Regional Referral Hospital, Bwizibwera Health Centre IV and Kinoni Health Centre IV located in Mbarara and Rwampara districts, southwestern Uganda. Data were collected from 30 postpartum mothers who were purposively selected, between 9th December 2019 and 25th September 2020. We analyzed this work using thematic data analysis and this was steered by the Colaizzi’s six-step phenomenological approach of inquiry.

Results
The findings were summarized into five major themes: 1) somatic experiences including insomnia and headache, breast pain, poor breast milk production, weight loss and lack of energy; 2) difficulties in home and family life including overwhelming domestic chores, lack of social support from other family members, fighting at home and financial constraints due to COVID-19 pandemic; 3) negative emotions including anger, self-blame, despondency and feelings of loneliness and regrets of conceiving or marriage; 4) feelings of suicide, homicide and self-harm including suicidal ideation and attempt, homicidal ideations and attempt and feelings of self-harm and 5) coping with postpartum depression including spirituality, termination of or attempt to leave their marital relationships, acceptance, counselling and seeking medical treatment, perseverance.

Conclusion and recommendations
Suicidal and homicidal thoughts are important parts of the postpartum depression experience, and these may put the lives of the mothers, their spouses and their babies at a great risk. Poor relationship quality, intimate partner violence and lack of financial resources contribute significantly to the negative emotional experiences of mothers with PPD.
Visual impairment and associated factors among pregnant women attending antenatal care units at health institutions in Gondar City Administration, Northwest Ethiopia
Authors: Diress Mengistie , Belsti Yitayeh , Getnet Mihret , Fekadu Sofonias Addis , Dagnew Baye , Akalu Yonas , Seid Mohammed Abdu , Gela Yibeltal Yismaw 
Published: December 2021

AbstractBackgroundVisual impairment is a major public health concern among women of reproductive age groups in Ethiopia, which is getting worse during pregnancy. Though visual impairment has lots of serious consequences across the life course of pregnant women, there is no previous study on this topic in Ethiopia. Thus, this study determined the prevalence of visual impairment and identified associated factors among pregnant women attending antenatal care units at the governmental health institutions in Gondar City Administration, Northwest Ethiopia.MethodsAn institution-based cross-sectional study was conducted. A systematic random sampling technique was used to recruit the study participants. We used an interviewer-administered questionnaire comprising of socio-demographic, clinical and pregnancy-related variables to collect the required data. Snellen’s illiterate “E” chart was used to determine visual impairment. EpiData 3 and Stata 14 were used for data entry and statistical analysis, respectively. Both bivariable and multivariable binary logistic regression analyses were executed to identify associated factors of visual impairment. Variables with ap-value ≤0.05 in the multivariable logistic regression analysis were declared as statistically significant with visual impairment.ResultsA total of 417 (response rate = 98.6%) participants were involved in this study, with a median age of 27 years. The overall prevalence of visual impairment was 22.5% (95% CI: 18.5–26.6). Thirty (7.2%) and thirty-two (7.7%) of the study participants had moderate to severe visual impairments in their right and left eyes, respectively. Participants aged from 31 to 49 years (AOR = 2.1; 95% CI: 1.1–4.0), being 3rd trimester (AOR = 2.4; 95% CI: 1.3–4.5), multi & grand multipara (AOR = 2.3; 95% CI: 1.2–4.6), and history of contraceptive use (AOR = 2.7; 95% CI: 1.2–6.3) had higher chance ofvisual impairment.ConclusionThe magnitude of visual impairment among pregnant women was high in the study area. Therefore, routine screening and evaluation of pregnant women for visual condition during antenatal care visits is recommended. Further investigations of visual changes, particularly as a result of pregnancy, are warranted.
Acute malnutrition and its determinants of preschool children in Bangladesh: gender differentiation
Authors: Karim Md. Reazul , Al Mamun Abu Sayed Md. , Rana Md. Masud , Mahumud Rashidul Alam , Shoma Nurun Naher , Dutt Dhiman , Bharati Premananda , Hossain Md. Golam 
Published: December 2021

Abstract
Background
Children acute malnutrition (AM) is a global public health concern, especially in low and middle income countries. AM is associated with multiple physiological vulnerabilities, including immune dysfunction, enteric barrier disruption, gut microbiome dysbiosis, and essential nutrient deficits. This study aimed to determine the prevalence of AM and its associated factors among preschool children in Rajshahi district, Bangladesh.

Methods
This cross-sectional study was conducted from October to December, 2016. Children acute malnutrition was assessed using mid-upper arm circumference. Multiple binary logistic regression analyses were employed to determine the associated factors after adjusting the effect of independent factors of children AM.

Result
The prevalence of AM amongst preschool children was 8.7%, among them 2.2 and 6.5% were severe acute malnutrition and moderate acute malnutrition, respectively. Z-proportional test demonstrated that the difference in AM between girls (11.6) and boys (5.9%) was significant (p < 0.05). Children AM was associated with being: (i) children aged 6–23 months (aOR = 2.29, 95% CI: 1.20–4.37; p < 0.05), (ii) early childbearing mothers’ (age < 20 years) children (aOR = 3.06, 95% CI: 1.08–8.66; p < 0.05), (iii) children living in poor family (aOR = 3.08, 95% CI: 1.11–8.12; p < 0.05), (iv) children living in unhygienic latrine households (aOR = 2.81, 95% CI: 1.52–5.09; p < 0.01), (v) Hindu or other religion children (aOR = 0.42, 95% CI: 0.19–0.92; p < 0.05).

Conclusion
The prevalence of AM was high among these preschool children. Some modifiable factors were associated with AM of preschool children. Interventions addressing social mobilization and food security could be an effective way to prevent acute malnutrition among children in Bangladesh.
Facilitators and barriers to antiretroviral therapy adherence among HIV-positive adolescents living in Tanzania
Authors: Audi Cosette , Jahanpour Ola , Antelman Gretchen , Guay Laura , Rutaihwa Mastidia , van de Ven Roland , Woelk Godfrey , Baird Sarah J. 
Published: December 2021

Abstract
Background
Adolescents living with HIV face substandard outcomes along the continuum of care, including higher rates of poor adherence and virologic failure. Support groups have been identified as a method to improve adherence, but there is insufficient evidence regarding their effectiveness. This study seeks to examine the protective influences for and barriers to antiretroviral therapy (ART) adherence in HIV-positive adolescents living in Tanzania.

Methods
This is a qualitative study conducted in Tanzania from January to March 2018. The sample of adolescents aged 10-19 (n = 33) was purposefully selected based on age, gender, and support group attendance to capture a broad range of experiences. Participants completed an in-depth interview, covering topics such as retention in HIV services, support group experiences, and joys and challenges of adolescent life. Interviews were coded and themes related to ART adherence were identified and summarized.

Results
Support groups helped promote adherence by improving adolescents’ knowledge and confidence. Participants associated joining support groups with an improvement in health. Almost every participant described the significant positive influence a treatment supporter had on adherence. Adolescents’ daily schedules and emotional state served as a barrier to adherence. Furthermore, adherence was negatively impacted by participants’ fear of accidental disclosure.

Conclusion
Logistical and psychosocial factors can hinder adherence. Interventions that provide both education and psychosocial support, such as peer support groups, have the potential to improve health outcomes for this population, but may not address more persistent barriers to adherence rooted in lack of treatment support from family members or friends who have not been disclosed to, or lack of transportation funds/food security.