bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduction of oxidative stress and apoptosis in hyperlipidemic rats by composite oil (CO) of Sesamum indicum L. and Vicia faba L.
Authors: Khatun Holima , Mitra Mousumi , Das Koushik , Chattopadhyay Atiskumar , Nandi Dilip Kumar 
Published: January 2021

BACKGROUND: Hyperlipidemia associated with cardiovascular diseases (CVDs) is a global health issue that can be alleviated by functional foods. OBJECTIVES: The present study aimed to investigate the effect of composite oil (CO) of sesame seed oil (S SiO) and Vicia faba seed oil (S VfO) on inflammatory factors, ROS generation level, and cell apoptosis level on high lipid diet (HLD) induced hyperlipidemic rat model. METHODS: Hyperlipidemic rat model was developed by feeding HLD to the experimental rats for eight weeks. Male albino rats weighing around 200–210 g were randomly divided into three equal groups: group I: control, received a normal diet; group II: received HLD for eight weeks, and group III: received the HLD with CO orally. After 60 days of treatment, the levels of C-reactive protein (CRP), interleukin (IL)-10; tumor necrosis factor (TNF)-α, IL-18, reactive oxygen species (ROS), and cell apoptosis were serially assessed. RESULTS: After eight weeks of CO treatment, TNF- α, IL-18, CRP, and oxidative ROS generation significantly decreased in CO treated group (group III) compared to group II. On the other hand, IL-10 levels significantly increased in CO treated group compared to group II animals. It was also observed that the percentage of the late apoptotic cell reduced considerably in the CO treated group (group III) compared to HLD-fed animals (group II). CONCLUSION: The results indicate that the CO could prevent CVDs via suppressing oxidative stress, and ameliorating inflammation and apoptosis in hyperlipidemic rats.
PENGARUH KUALITAS PENGANGGARAN DAN KOMPETENSI SUMBER DAYA MANUSIA BIDANG KEUANGAN TERHADAP KINERJA KEUANGAN SEKOLAH
Authors: FAUZAN SLAMET 
Published: January 2021

This research was conducted to identity the influence of budget quality and financial human resources competence on the school financial performance.. This research is population research. The number of population in this research is among all the vocational haigh school in Pemalang Regency with totaling 42 schools. Of the 42 schools, only 37 schools who returned the questioners.
This research used quantitative approach using hypothesis testing study design. To test hypothesis using multiple linier regression analysis with the absolute different with application program SPSS. The result of analysis shows that quality of budgeting and financial human resources competence on the school have a positive significant effect on the school financial performance with simultanely or partially.
Pemilihan Ibukota Negara Republik Indonesia Baru Berdasarkan Tingkat Kebencanaan
Authors: Kurniadi Anwar 
Published: January 2021

The consideration to removal of Indonesia Republic United States capital has happened to four president’s era, Soekarno, Soeharto, Susilo Bambang Yudhoyono, and Joko Widodo, the removal of Indonesia capital were due to economical and political reasons. Other reasons was less of environment capacity to support capital’s activities. This condition It showed by rising traffic jam, polutions and often happened flood disaster. The purpose of this paper is to analize the capital requirenment from disaster analysis, disaster risk, and disaster potent. The method used literature review with using data analize of Mile and Huberman. Results and discussion showed that all provinces the South Kalimantan, the Center Kalimantan and the East Kalimantan have same disaster, like as forest fire forest especialy from peat, drought, rob flood, earthquake, and also tsunami. However, the province of the South Kalimantan, on fact, It has the most minimal of disaster risk and disaster potent. The conclusion was the South Kalimantan would be the first choice to be the new of Indonesia Capital from disaster analysis aspect at where the most minimal of risk and potent of disasters.
Measurement of T1 Mapping in Patients With Cardiac Devices: Off-Resonance Error Extends Beyond Visual Artifact but Can Be Quantified and Corrected
Authors: Bhuva Anish N. , Treibel Thomas A. , Seraphim Andreas , Scully Paul , Knott Kristopher D. , Augusto João B. , Torlasco Camilla , Menacho Katia , Lau Clement , Patel Kush , Moon James C. , Kellman Peter , Manisty Charlotte H. 
Published: January 2021

Background: Measurement of myocardial T1 is increasingly incorporated into standard cardiovascular magnetic resonance (CMR) protocols, however accuracy may be reduced in patients with metallic cardiovascular implants. Measurement is feasible in segments free from visual artifact, but there may still be off-resonance induced error.Aim: To quantify off-resonance induced T1 error in patients with metallic cardiovascular implants, and validate a method for error correction for a conventional MOLLI pulse sequence.Methods: Twenty-four patients with cardiac implantable electronic devices (CIEDs: 46% permanent pacemakers, PPMs; 33% implantable loop recorders, ILRs; and 21% implantable cardioverter-defibrillators, ICDs); and 31 patients with aortic valve replacement (AVR) (45% metallic) were studied. Paired mid-myocardial short-axis MOLLI and single breath-hold off-resonance field maps were acquired at 1.5 T. T1 values were measured by AHA segment, and segments with visual artifact were excluded. T1 correction was applied using a published relationship between off-resonance and T1. The accuracy of the correction was assessed in 10 healthy volunteers by measuring T1 before and after external placement of an ICD generator next to the chest to generate off-resonance.Results: T1 values in healthy volunteers with an ICD were underestimated compared to without (967 ± 52 vs. 997 ± 26 ms respectively, p = 0.0001), but were similar after correction (p = 0.57, residual difference 2 ± 27 ms). Artifact was visible in 4 ± 12, 42 ± 31, and 53 ± 27% of AHA segments in patients with ILRs, PPMs, and ICDs, respectively. In segments without artifact, T1 was underestimated by 63 ms (interquartile range: 7–143) per patient. The greatest error for patients with ILRs, PPMs and ICDs were 79, 146, and 191 ms, respectively. The presence of an AVR did not generate T1 error.Conclusion: Even when there is no visual artifact, there is error in T1 in patients with CIEDs, but not AVRs. Off-resonance field map acquisition can detect error in measured T1, and a correction can be applied to quantify T1 MOLLI accurately.
Postadychute-AG, Detection, and Prevention of the Risk of Falling Among Elderly People in Nursing Homes: Protocol of a Multicentre and Prospective Intervention Study
Authors: Quijoux Flavien , Bertin-Hugault François , Zawieja Philippe , Lefèvre Marie , Vidal Pierre-Paul , Ricard Damien 
Published: January 2021

Introduction: While falls among the elderly is a public health issue, because of the social, medical, and economic burden they represent, the tools to predict falls are limited. Posturography has been developed to distinguish fallers from non-fallers, however, there is too little data to show how predictions change as older adults' physical abilities improve. The Postadychute-AG clinical trial aims to evaluate the evolution of posturographic parameters in relation to the improvement of balance through adapted physical activity (APA) programs.Methods: In this prospective, multicentre clinical trial, institutionalized seniors over 65 years of age will be followed for a period of 6 months through computer-assisted posturography and automatic gait analysis. During the entire duration of the follow-up, they will benefit from a monthly measurement of their postural and locomotion capacities through a recording of their static balance and gait thanks to a software developed for this purpose. The data gathered will be correlated with the daily record of falls in the institution. Static and dynamic balance measurements aim to extract biomechanical markers and compare them with functional assessments of motor skills (Berg Balance Scale and Mini Motor Test), expecting their superiority in predicting the number of falls. Participants will be followed for 3 months without APA and 3 months with APA in homogeneous group exercises. An analysis of variance will evaluate the variability of monthly measures of balance in order to record the minimum clinically detectable change (MDC) as participants improve their physical condition through APA.Discussion: Previous studies have stated the MDC through repeated measurements of balance but, to our knowledge, none appear to have implemented monthly measurements of balance and gait. Combined with a reliable measure of the number of falls per person, motor capacities and other precipitating factors, this study aims to provide biomechanical markers predictive of fall risk with their sensitivity to improvement in clinical status over the medium term. This trial could provide the basis for posturographic and gait variable values for these elderly people and provide a solution to distinguish those most at risk to be implemented in current practice in nursing homes.Trial Registration: ID-RCB 2017-A02545-48.Protocol Version: Version 4.2 dated January 8, 2020.
MushPEC: Correcting Post-entrapment Processes Affecting Melt Inclusions Hosted in Olivine Antecrysts
Authors: Brahm Raimundo , Zellmer Georg F. , Kuritani Takeshi , Coulthard Daniel , Nakagawa Mitsuhiro , Sakamoto Naoya , Yurimoto Hisayoshi , Sato Eiichi 
Published: January 2021

Olivine-hosted melt inclusions (MIs) are widely used as a tool to study the early stages of magmatic evolution. There are a series of processes that affect MI compositions after trapping, including post-entrapment crystallization (PEC) of the host mineral at the MI boundaries, exsolution of volatile phases into a “shrinkage bubble” and diffusive exchange between a MI and its host. Classical correction schemes applied to olivine-hosted MIs include PEC correction through addition of olivine back to the melt until it reaches equilibrium with the host composition and “Fe-loss” correction due to Fe-Mg diffusive exchange. These corrections rely on the assumption that the original host composition is preserved. However, for many volcanic samples the crystal cargo is thought to be antecrystic, and the olivine composition may thus have been completely re-equilibrated during long crystal storage times. Here, we develop a novel MI correction scheme that is applicable when the original host crystal composition has not been preserved and the initial MI composition variability can be represented by simple fractional crystallization (FC). The new scheme allows correction of MI compositions in antecrystic hosts with long and varied temperature histories. The correction fits a set of MI compositions to modelled liquid lines of descent generated by FC. A MATLAB®script (called MushPEC) iterates FC simulations using the rhyolite-MELTS algorithm. In addition to obtaining the corrected MI compositions, the application of this methodology provides estimations of magmatic conditions during MI entrapment. A set of MIs hosted in olivine crystals of homogeneous composition (Fo77–78) from a basaltic tephra of Akita-Komagatake volcano was used to test the methodology. The tephra sample shows evidence of re-equilibration of the MIs to a narrow Mg# range equivalent to the carrier melt composition. The correction shows that olivine hosts were stored in the upper crust (c.125 – 150 MPa) at undersaturated H2O contents ofc. 1 – 2 wt% H2O).
Evaluation of Glacial Lake Outburst Flood Susceptibility Using Multi-Criteria Assessment Framework in Mahalangur Himalaya
Authors: Khadka Nitesh , Chen Xiaoqing , Nie Yong , Thakuri Sudeep , Zheng Guoxiong , Zhang Guoqing 
Published: January 2021

Ongoing recession of glaciers in the Himalaya in response to global climate change has far-reaching impacts on the formation and expansion of glacial lakes. The subsequent glacial lake outburst floods (GLOFs) are a significant threat to lives and livelihoods as they can cause catastrophic damage up to hundreds of kilometres downstream. Previous studies have reported the rapid expansion of glacial lakes and several notable destructive past GLOF events in the Mahalangur Himalaya, suggesting a necessity of timely and updated GLOF susceptibility assessment. Here, an updated inventory of glacial lakes across the Mahalangur Himalaya is developed based on 10-m Sentinel-2 satellite data from 2018. Additionally, the GLOF susceptibilities of glacial lakes (≥0.045 km2) are evaluated using a multi-criteria-based assessment framework where six key factors are selected and analyzed. Weight for each factor was assigned from the analytical hierarchy process. Glacial lakes are classified into very low, low, medium, high, and very high GLOF susceptibility classes depending upon their susceptibility index based on analysis of three historical GLOF events in the study area. The result shows the existence of 345 glacial lakes (&gt;0.001 km2) with a total area of 18.80 ± 1.35 km2 across the region in 2018. Furthermore, out of the 64 glacial lakes (≥0.045 km2) assessed, seven were identified with very high GLOF susceptibility. We underline that pronounced glacier-lake interaction will likely increase the GLOF susceptibility. Regular monitoring and more detailed fieldworks for these highly susceptible glacial lakes are necessary. This will benefit in early warning and disaster risk reduction of downstream communities.
Meteorological Conditions and Cloud Effects on Surface Radiation Balance Near Helheim Glacier and Jakobshavn Isbræ (Greenland) Using Ground-Based Observations
Authors: Djoumna G. , Mernild S. H. , Holland D. M. 
Published: January 2021

The surface radiation budget is an essential component of the total energy exchange between the atmosphere and the Earth’s surface. Measurements of radiative fluxes near/on ice surfaces are sparse in the polar regions, including on the Greenland Ice Sheet (GrIS), and the effects of cloud on radiative fluxes are still poorly studied. In this work, we assess the impacts of cloud on radiative fluxes using two metrics: the longwave-equivalent cloudiness, derived from long-wave radiation measurements, and the cloud transmittance factor, obtained from short-wave radiation data. The metrics are applied to radiation data from two automatic weather stations located over the bare ground near the ice front of Helheim (HG, 66.3290°N, 38.1460°W) and Jakobshavn Isbræ(JI, 69.2220°N, 49.8150°W) on the GrIS. Comparisons of meteorological parameters, surface radiation fluxes, and cloud metrics show significant differences between the two sites. The cloud transmittance factor is higher at HG than at JI, and the incoming short-wave radiation in the summer at HG is about 50.0 W m−2 larger than at JI. Cloud metrics derived at the two sites reveal partly cloudy conditions were frequent (42 and 65% of the period at HG and JI) with a high dependency on the wind direction. The total cloud radiative effect (CREnet) generally increases during melt season at the two stations due to long-wave CRE enhancement by cloud fraction. CREnet decreases from May to June and increases afterward, due to the strengthened short-wave CRE. The annually averaged CREnet were 3.0 ± 7.4 W m−2 and 1.9±15.1 W m−2 at JI and HG. CREnet estimated from AWS indicates that clouds cool the JI and HG during melt season at different rates.
Expansion of Monocytic Myeloid-Derived Suppressor Cells in Patients Under Hemodialysis Might Lead to Cardiovascular and Cerebrovascular Events
Authors: Xing Yan-Fang , Cai Jia-Rong , Qin Jun-Jian , Zhou Wen-Ying , Li Can-Ming , Li Xing 
Published: January 2021

BackgroundThe specific mechanism of cardiovascular and cerebrovascular vasculopathy in the context of end-stage renal disease has not been elucidated. In the present study, we investigated the clinical impact of myeloid-derived suppressor cells (MDSCs) on hemodialysis patients and their mechanism of action.MethodsMDSCs were tested among 104 patients undergoing hemodialysis and their association with overall survival (OS) and cardiovascular and cerebrovascular events was determined.ResultsHemodialysis patients presented a significantly higher level of monocytic MDSCs (M-MDSCs) compared to healthy controls. M-MDSC were tested 3 months after first testing among 103 hemodialysis patients, with one patient not retested due to early death. The repeated results of M-MDSC levels were consistent with the initial results. Patients with persistent high level of M-MDSCs presented decreased OS, as well as increased stroke and acute heart failure events. As illustrated by multivariate Cox regression, M-MDSC was an independent predictor for OS and stroke events of hemodialysis patients. T cell proliferations were significantly abrogated by hemodialysis-related M-MDSCs in a dose-dependent manner. Besides, M-MDSCs presented higher levels of CXCR4 and VLA-4 compared to monocytes, which indicated their enhanced capability to be recruited to atherosclerotic lesions. The expression of arginase I and activity of arginase was also significantly raised in hemodialysis-related M-MDSCs. Human coronary arterial endothelial cells (HCAECs) presented increased capability to migration by coculture with M-MDSCs, compared with monocyte group. Arginase inhibitor and L-arginine abrogated the immune suppressive function and induction of HCAECs migration of hemodialysis related M-MDSC. Plasma IFN-γ, TNF-α and IL-6 were elevated in hemodialysis patients compared with healthy control. M-MDSC level was positively related to IL-6 level among hemodialysis patients. The plasma of hemodialysis patients induced M-MDSCs significantly compared with plasma from health donors. Besides, IL-6 neutralizing antibody significantly abrogated the induction. Neutralizing antibody of IFN-γ and TNF-α partially decreased the generation of arginase of the induced M-MDSC.ConclusionsM-MDSCs were elevated in ESRD patients under hemodialysis, and they exhibited a strong association with the risk of cardiovascular and cerebrovascular diseases. Hemodialysis related M-MDSC presented enhanced recruitment to atherosclerotic lesions, promoted the migration of endothelial cells through exhaustion of local L-arginine.
Immune Responses to Gram-Negative Bacteria in Hemolymph of the Chinese Horseshoe Crab, Tachypleus tridentatus
Authors: Wang Wei-Feng , Xie Xiao-Yong , Chen Kang , Chen Xiu-Li , Zhu Wei-Lin , Wang Huan-Ling 
Published: January 2021

Chinese horseshoe crab, Tachypleus tridentatus, is an ancient marine arthropod with a long evolutionary history. As a kind of living fossil species, the pathogen defenses of horseshoe crabs entirely depend on the innate immune system. Although, there are abundant immune molecules found in the horseshoe crab hemolymph, the biological mechanisms underlying their abilities of distinguishing and defending against invading microbes are still unclear. In this study, we used high-throughput sequencing at mRNA and protein levels and bioinformatics analysis methods to systematically analyze the innate immune response to Gram-negative bacteria in hemolymph of Chinese horseshoe crab. These results showed that many genes in the complement and coagulation cascades, Toll, NF-κB, C-type lectin receptor, JAK-STAT, and MAPK signaling pathways, and antimicrobial substances were activated at 12 and 24 h post-infection, suggesting that Gram-negative bacteria could activate the hemolymph coagulation cascade and antibacterial substances release via the above pathways. In addition, we conjectured that Toll and NF-κB signaling pathway were most likely to participate in the immune response to Gram-negative bacteria in hemolymph of horseshoe crab through an integral signal cascade. These findings will provide a useful reference for exploring the ancient original innate immune mechanism.
Tregs and Mixed Chimerism as Approaches for Tolerance Induction in Islet Transplantation
Authors: Pathak Shiva , Meyer Everett H. 
Published: January 2021

Pancreatic islet transplantation is a promising method for the treatment of type 1 and type 3 diabetes whereby replacement of islets may be curative. However, long-term treatment with immunosuppressive drugs (ISDs) remains essential for islet graft survival. Current ISD regimens carry significant side-effects for transplant recipients, and are also toxic to the transplanted islets. Pre-clinical efforts to induce immune tolerance to islet allografts identify ways in which the recipient immune system may be reeducated to induce a sustained transplant tolerance and even overcome autoimmune islet destruction. The goal of these efforts is to induce tolerance to transplanted islets with minimal to no long-term immunosuppression. Two most promising cell-based therapeutic strategies for inducing immune tolerance include T regulatory cells (Tregs) and donor and recipient hematopoietic mixed chimerism. Here, we review preclinical studies which utilize Tregs for tolerance induction in islet transplantation. We also review myeloablative and non-myeloablative hematopoietic stem cell transplantation (HSCT) strategies in preclinical and clinical studies to induce sustained mixed chimerism and allograft tolerance, in particular in islet transplantation. Since Tregs play a critical role in the establishment of mixed chimerism, it follows that the combination of Treg and HSCT may be synergistic. Since the success of the Edmonton protocol, the feasibility of clinical islet transplantation has been established and nascent clinical trials testing immune tolerance strategies using Tregs and/or hematopoietic mixed chimerism are underway or being formulated.
Disease Severity, Fever, Age, and Sex Correlate With SARS-CoV-2 Neutralizing Antibody Responses
Authors: Schlickeiser Stephan , Schwarz Tatjana , Steiner Sophie , Wittke Kirsten , Al Besher Nabeel , Meyer Oliver , Kalus Ulrich , Pruß Axel , Kurth Florian , Zoller Thomas , Witzenrath Martin , Sander Leif Erik , Müller Marcel A. , Scheibenbogen Carmen , Volk Hans-Dieter , Drosten Christian , Corman Victor M. , Hanitsch Leif G. 
Published: January 2021

Clinical trials on the use of COVID-19 convalescent plasma remain inconclusive. While data on safety is increasingly available, evidence for efficacy is still sparse. Subgroup analyses hint to a dose-response relationship between convalescent plasma neutralizing antibody levels and mortality. In particular, patients with primary and secondary antibody deficiency might benefit from this approach. However, testing of neutralizing antibodies is limited to specialized biosafety level 3 laboratories and is a time- and labor-intense procedure. In this single center study of 206 COVID-19 convalescent patients, clinical data, results of commercially available ELISA testing of SARS-CoV-2 spike-IgG and –IgA, and levels of neutralizing antibodies, determined by plaque reduction neutralization testing (PRNT), were analyzed. At a medium time point of 58 days after symptom onset, only 12.6% of potential plasma donors showed high levels of neutralizing antibodies (PRNT50 ≥ 1:320). Multivariable proportional odds logistic regression analysis revealed need for hospitalization due to COVID-19 (odds ratio 6.87; p-value 0.0004) and fever (odds ratio 3.00; p-value 0.0001) as leading factors affecting levels of SARS-CoV-2 neutralizing antibody titers in convalescent plasma donors. Using penalized estimation, a predictive proportional odds logistic regression model including the most important variables hospitalization, fever, age, sex, and anosmia or dysgeusia was developed. The predictive discrimination for PRNT50 ≥ 1:320 was reasonably good with AUC: 0.86 (with 95% CI: 0.79–0.92). Combining clinical and ELISA-based pre-screening, assessment of neutralizing antibodies could be spared in 75% of potential donors with a maximal loss of 10% of true positives (PRNT50 ≥ 1:320).