bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of previous macrolide use on invasive pneumococcal disease due to erythromycin-resistant serotypes in adults over 59 years of age
Authors: Chávez Abelardo Claudio Fernández , Comas Luis García , Espinosa Luis Manzano , Lobo Jose Yuste , de Provens Octavio Corral Pazos , Andrés Jesús María Aranaz 
Published: October 2021

AbstractThe major goals of the study were to describe the invasive pneumococcal disease (IPD) cases due to erythromycin-resistant serotypes and to evaluate the association between these cases and recent macrolide use in individuals aged over 59 years. We selected cases of IPD reported between 2007 and 2016 in persons aged over 59 years living in the Community of Madrid (CM). We followed the European Committee on Antimicrobial Susceptibility Testing (EUCAST). The explanatory variables (age, sex, year of onset of symptoms, clinical presentation, serotypes, vaccination status) were taken from the Mandatory Notification System for Infectious Diseases System and from the Vaccination Information System. The cases were classified as either included in the 13-valent pneumococcal conjugate vaccine (PCV13) or not (nonPCV13). Associations between cases due to erythromycin-resistant serotypes and previous macrolide use (total, long and short-term) were adjusted with a logistic regression multivariate analysis. A total of 1,831 cases were identified, of whom 408 were erythromycin-resistant serotypes. PCV13 cases were associated with previous macrolide use (OR: 5.07), particularly long-acting types (OR: 8.61). NonPCV13 cases were associated with the use of total macrolides (OR: 3.48) and long-acting macrolides (OR: 4.26) suggesting that PCV13 did not reduce the IPD cases in patients with previous use of macrolides. Our results confirmed that previous macrolide consumption was associated with the presence of IPD due to erythromycin-resistant serotypes. The risk was higher with the use of long-term macrolides.
Deliberation Without Democracy in Multi-stakeholder Initiatives: A Pragmatic Way Forward
Authors: Barlow Rob 
Published: October 2021

AbstractPolitical CSR scholars argue that multi-stakeholder initiatives (MSIs) should be designed to facilitate deliberation among corporations, civil society groups, and others affected by corporate conduct for their decisions to be considered democratically legitimate. However, critics argue that decisions reached within deliberative MSIs will lack democratic legitimacy so long as corporations are granted a role in helping to make them. If the critics are correct, it leads to a paradox. Corporations must be excluded from holding decision-making authority within MSIs if they are to function as democratically legitimate regulatory institutions at a global level. However, this risks severely diminishing the incentive of corporations to support and participate within MSIs, which often depend heavily for their success on the visibility provided them by corporate participants. In this paper, I argue that this apparent paradox should be considered irrelevant to the future study of MSIs since it is both unnecessary and impractical for researchers to focus on establishing democratically legitimate systems of governance within them. Instead, I recommend an approach informed by three touchstones of pragmatic philosophy to guide their future study—a criterion of usefulness, wariness of category disputes and commitment to experimentalism. I conclude by drawing on research in political science and social psychology that demonstrates an important practical role for deliberation within such organizations, arguing that researchers must zero in on the role that inclusive deliberation can play in bolstering their effectiveness as regulatory instruments.
The Current Status of the World’s Primates: Mapping Threats to Understand Priorities for Primate Conservation
Authors: Fernández David , Kerhoas Daphne , Dempsey Andrea , Billany Josephine , McCabe Gráinne , Argirova Elitsa 
Published: October 2021

AbstractOver the past decades, primate populations have been declining. Four years ago, >60% of species were listed as threatened. As the rate of loss accelerates and new IUCN assessments are being published, we used IUCN Red List assessments and peer-reviewed literature published within the last 5 yr to evaluate the status of primates globally, by region and by taxonomic group. We also examined the main factors affecting a species’ conservation status to determine if we could predict the status of understudied species. We found that 65% of species are in the top three IUCN Red List categories (Vulnerable, Endangered, Critically Endangered). Globally, the main threats to primates are Biological Resource Use, including Hunting & Logging, and Agriculture. The impact of these threats varied by region and taxon. Our model showed that Malagasy and Asian primates, and those affected by Agriculture, Human Disturbance, and Climate Change were more likely to be considered at risk of extinction. The model’s predictive probability, however, was low. Our literature analysis showed that some threats, especially climate change and disease, affected more species than indicated by the IUCN Red List. As we move into the next decade, we must continue tackling hunting and agricultural expansion but also be vigilant about emerging threats. We must also aim to regularly test the effectiveness of mitigation strategies, evaluating their long-term adoption and their impact on primates; as well as to increase communication between researchers and applied conservationists to ensure IUCN assessments include current and emerging threats.
Study on low-frequency dielectric behavior of the carbon black/polymer nanocomposite
Authors: Shivashankar H. , Mathias Kevin Amith , Sondar Pavankumar R. , Shrishail M. H. , Kulkarni S. M. 
Published: October 2021

AbstractRecently, polymer-based dielectric materials have become one of the key materials to play an essential role in clean energy production, energy transformation, and energy storage applications. The end usage is the energy storage capability because it is a trade-off between dielectric permittivity, dielectric loss, and dissipation factor. Hence, it is of prime importance to study the dielectric properties of polymer materials by adding filler material at a low-frequency range. In the present study, polydimethylsiloxane/carbon black nanocomposites are prepared using the solution cast method. The dielectric properties, such as dielectric constant, dielectric loss, and dissipation factors due to the concentration of filler particles and low-frequency effect on the nanocomposites, are examined. Also, different empirical models are used to estimate the dielectric permittivity of polymer nanocomposites. The low-frequency range of 100 Hz to 1 MHz and the effect of varying volume fractions of carbon black show a significant change in the dielectric properties. It is found that the nanocomposites have a higher dielectric permittivity than the base polymer material. It is also observed that an increase in filler concentration increases the dielectric permittivity, which is confirmed with an empirical model.
MicroRNA-506 modulates insulin resistance in human adipocytes by targeting S6K1 and altering the IRS1/PI3K/AKT insulin signaling pathway
Authors: Zhong Feng-Yu , Li Jing , Wang Yu-Mei , Chen Yao , Song Jia , Yang Zi , Zhang Lin , Tian Tian , Hu You-Fang , Qin Zhen-Ying 
Published: October 2021

AbstractThe incidence of obesity has increased rapidly, becoming a worldwide public health issue that involves insulin resistance. A growing number of recent studies have demonstrated that microRNAs play a significant role in controlling the insulin signaling network. For example, miR-506-3p expression has been demonstrated to correlate with insulin sensitivity; however, the underlying mechanism remains unknown. In this study, we found that miR-506-3p enhanced glucose uptake by 2-deoxy-D-glucose uptake assays and regulated the protein expression of key genes involved in the PI3K/AKT insulin signaling pathway including IRS1, PI3K, AKT, and GlUT4. We next predicted ribosomal protein S6 kinase B1 (S6K1) to be a candidate target of miR-506-3p by bioinformatics analysis and confirmed using dual-luciferase assays that miR-506-3p regulated S6K1 expression by binding to its 3′-UTR. Moreover, modulating S6K1 expression counteracted the effects of miR-506-3p on glucose uptake and PI3K/AKT pathway activation. In conclusion, miR-506-3p altered IR in adipocytes by regulating S6K1-mediated PI3K/AKT pathway activation. Taken together, these findings provide novel insights and potential targets for IR therapy.
Enhanced TOA Estimation Using OFDM over Wide-Band Transmission Based on a Simulated Model
Authors: Obeidat Huthaifa A. , Ahmad Imran , Rawashdeh Mohammad R. , Abdullah Ali A. , Shuaieb Wafa S. , Obeidat Omar A. , Abdallhameed Raed A. 
Published: October 2021

AbstractThis paper presents the advantages of using a wideband spectrum adopting multi-carrier to improve targets localization within a simulated indoor environment using the Time of Arrival (TOA) technique. The study investigates the effect of using various spectrum bandwidths and a different number of carriers on localization accuracy. Also, the paper considers the influence of the transmitters’ positions in line-of-sight (LOS) and non-LOS propagation scenarios. It was found that the accuracy of the proposed method depends on the number of sub-carriers, the allocated bandwidth (BW), and the number of access points (AP). In the case of using large BW with a large number of subcarriers, the algorithm was effective to reduce localization errors compared to the conventional TOA technique. The performance degrades and becomes similar to the conventional TOA technique while using a small BW and a low number of subcarriers.
Novel semi-decentralised mobile system for the sanitization and dehydration of septic sludge: a pilot-scale evaluation in the Jordan Valley
Authors: Kocbek Eva , Garcia Hector A. , Hooijmans Christine M. , Mijatović Ivan , Al-Addous Mohammad , Dalala Zakariya , Brdjanovic Damir 
Published: October 2021

AbstractThe provision of effective sanitation strategies has a significant impact on public health. However, the treatment of septic sludge still presents some challenges worldwide. Consequently, innovative technologies capable of an effective and efficient sludge treatment, mostly at a decentralized level, are in high demand to improve sanitation provision. To address this problem, this study evaluates a novel semi-decentralised mobile faecal sludge treatment system, the pilot-system for which consists of a combination of several individual processes including mechanical dewatering (MD), microwave (MW) drying, and membrane filtration (ultrafiltration [UF] and reverse osmosis [RO]). The system evaluation was carried out by treating raw, partially digested faecal sludge (FS) from septic tanks—hence, septic sludge (SS)—in the Jordan Valley, Jordan. The pilot-scale system exhibited an effective and flexible treatment performance for (i) sanitizing faecal sludge and related liquid streams (MW and UF); (ii) reducing the treated sludge mass (and sludge volume) (MD and MW); and (iii) producing a high-quality treated liquid stream ideal for water reclamation applications (UF and RO). The MD process removed approximately 99% of the initial SS water content. The MW drying system completely removed E. coli and dehydrated the dewatered sludge at low energy expenditures of 0.75 MJ kg−1 and 5.5 MJ kg−1, respectively. Such energy expenditures can be further reduced by approximately 40% by recovering energy in the condensate and burning the dried sludge, which can then be reused inland applications. The membrane filtration system (UF and RO) was able to produce high-quality treated water that is ideal for the water reuse applications that irrigation requires, as well as meeting the Jordanian standard 893/2006. In addition, the system can also be powered by renewable energy sources, such as photovoltaic energy. Therefore, this research demonstrates that the evaluated semi-decentralised mobile system is technically feasible for the in situ treatment of SS (sanitization and dehydration), while also being effective for simultaneously recovering valuable resources, such as energy, water, and nutrients.
Criminal Law Exceptionalism as an Affirmative Ideology, and its Expansionist Discontents
Authors: Burchard Christoph 
Published: October 2021

AbstractCriminal law exceptionalism, or so I suggest, has turned into an ideology in German and Continental criminal law theory. It rests on interrelated claims about the (ideal or real) extraordinary qualities and properties of the criminal law and has led to exceptional doctrines in constitutional criminal law and criminal law theory. It prima facie paradoxically perpetuates and conserves the criminal law, and all too often leads to ideological thoughtlessness, which may blind us to the dark sides of criminal laws in action.
Analyzing browsing across websites by machine learning methods
Authors: Falke Andreas , Hruschka Harald 
Published: October 2021

AbstractThe increasing importance of online distribution channels is paralleled by a rising interest in gaining insights into the customer journey and browsing behavior. We evaluate several machine learning methods (latent Dirichlet allocation, correlated topic model, structural topic model, replicated softmax model) with respect to their ability to reproduce the browsing behavior of households across websites. In addition, we compare these machine learning methods to a related classical technique, singular value decomposition. In our study, the replicated softmax model outperforms latent Dirichlet allocation, but the correlated topic model attains the overall best performance. Compared to singular value decomposition both the correlated topic model and the replicated softmax model lead to a more efficient compression of web browsing data. On the other hand, singular value decomposition surpasses latent Dirichlet allocation. We interpret results of the correlated topic model and the replicated softmax model by determining combinations of topics or hidden variables that are heterogeneous with respect to visited websites. We show that decision makers should not rely on bivariate measures of site visits, as these do not agree with measures of interdependences between sites that can be inferred from the correlated topic model or the replicated softmax model. We investigate how well topics or hidden variables measured by these methods predict yearly household expenditures. The correlated topic model leads to the best predictive performance, followed by the replicated softmax model. We also discuss how the replicated softmax model can be used to support online marketing decisions of websites.
Reversibly photochromic wood constructed by depositing microencapsulated/polydimethylsiloxane composite coating
Authors: Jia Zhen , Bao Wenhui , Tao Chengyun , Song Wenlong 
Published: October 2021

AbstractPhotochromic wood was fabricated by coating microencapsulated photochromic material (MP)/polydimethylsiloxane composites onto wood using a simple drop-coating method. Urea-melamine–formaldehyde resin was used to microencapsulate the photochromic material (PM) via in situ polymerization. The concentration of the MP affected the photochromic property of the wood surface. The total color change (ΔE*) reached 82.2 when the concentration of the composite coating is 8%. Adhesion tests confirmed that the composite coating adhered firmly to the wood. This method is potentially useful for the production of functional wooden products, such as anti-counterfeiting materials and aesthetic wood.
Possible harm from glucocorticoid drugs misuse in the early phase of SARS-CoV-2 infection: a narrative review of the evidence
Authors: Sarzani Riccardo , Spannella Francesco , Giulietti Federico , Di Pentima Chiara , Giordano Piero , Giacometti Andrea 
Published: October 2021

AbstractSince the publication of the RECOVERY trial, the use of glucocorticoid drugs (GC) has spread for the treatment of severe COVID-19 worldwide. However, the benefit of dexamethasone was largest in patients who received mechanical ventilation or supplemental oxygen therapy, while no benefit was found among patients without hypoxemia. In addition, a positive outcome was found in patients who received dexamethasone after several days of symptoms, while possible harm could exist if administered early. The right time interval for GC administration is still a matter of debate. Previous studies showed that an early GC use during the first phase of the disease, when viral replication peaks, may negatively affect the innate immune response through several mechanisms, such as the inhibition of pro-inflammatory and antiviral cytokine production and signaling pathway, including type I interferon, that is fundamental to counteract the virus and that was found to be impaired in several patients with life-threatening COVID-19. The GC misuse can lead to a more severe disease even in patients who do not have the established risk factors, such as obesity and cardiovascular diseases. In our focused review, we describe the role of immune response in viral infections, especially SARS-CoV-2, and discuss the potential harms of GC misuse in COVID-19.
Timed to save: the added value of accounting for hourly incidence of electricity savings from residential space-conditioning measures
Authors: Murphy Sean , Deason Jeff , Satchwell Andrew 
Published: October 2021

AbstractPrevious research has recognized that the value of measures that reduce electricity usage depends upon the timing of the savings generated, but the lack of hourly savings shapes has limited the demonstration of this concept. We develop empirical hourly savings shapes for residential space-conditioning measures from nearly 18,000 efficiency projects in California and show how they combine with the diurnal and seasonal variation in electricity system costs. We find that these measures (cooling replacements; windows, doors, and skylights; and other envelope measures) tend to save electricity when system costs are highest and that the hourly savings account for 1.4–1.5 times as much value as non-time-sensitive estimates of efficiency would predict. We present these impact multipliers for each measure to quantify the additional value revealed by the time-sensitive approach. We show that this additional value is similar in an evolving electricity grid with storage, rather than natural gas generation, as the marginal resource.
Psychological distance towards COVID-19: Geographical and hypothetical distance predict attitudes and mediate knowledge
Authors: Blauza Simon , Heuckmann Benedikt , Kremer Kerstin , Büssing Alexander Georg 
Published: October 2021

AbstractWhile different antecedents have been examined to explain peoples’ reactions towards COVID-19, there is only scarce understanding about the role of the subjective closeness and distance to the pandemic. Within the current study, we applied the concept of psychological distance to understand the distance towards COVID-19 and investigated its (1) connection with preventive attitudes and proactive behaviors, (2) context-specific antecedents, and its (3) mediating effect of knowledge on attitudes. Using an online sample from a German quantitative cross-sectional study (N = 395, M = 32.2 years, SD = 13.9 years, 64.3% female) in July 2020, a time with a general low incidence of people infected with Sars-CoV2, we measured relevant socio-psychological constructs addressing COVID-19 and included further information from external sources. Based on a path model, we found geographical distance as a significant predictor of cognitive attitudes towards COVID-19. Furthermore, hypothetical distance (i.e., feeling to be likely affected by COVID-19) predicted not only participants’ affective, cognitive, and behavioral attitudes, but also the installation of a corona warning-app. While several variables affected the different dimensions of psychological distance, hypothetical and geographical distance mediated the effect of knowledge on attitudes. These results underline the role of geographical and hypothetical distance for health-related behaviors and education. For example, people will only comply with preventive measures if they feel geographically concerned by the disease, which is particularly challenging for fast-spreading global diseases such as COVID-19. Therefore, there is a need to clearly communicate the personal risks of diseases and address peoples’ hypothetical distance.
Cybervictimisation and depressive symptoms among adolescents: A moderated mediation model
Authors: Chamizo-Nieto María Teresa , Rey Lourdes 
Published: October 2021

AbstractRecently, there has been an increase in the problem of cyberbullying all over the world, which implies important negative consequences for adolescent victims’ mental health, such as depression. There are few research studies that analyse the role of gratitude and cognitive coping strategies for the consequences of cybervictimisation. To date, there are few studies examining the influence of both these resources in a cyberbullying context. Therefore, the objectives of this research were to analyse the mediating role of maladaptive cognitive emotion regulation strategies (CERS) in the relationship between cybervictimisation and depressive symptoms, and to explore the potential moderating role of gratitude among the study variables. A sample of 1156 students between 12 and 18 years (54.33% females) filled out self-report questionnaires measuring cybervictimisation (ECIPQ), cognitive coping strategies (CERQ-SA), depressive symptoms (DASS-21) and gratitude (GQ-5). The outcomes showed that maladaptive CERS partially mediated the relation between cybervictimisation and depressive symptoms. Furthermore, gratitude buffered the relation between maladaptive CERS and depressive symptoms. These findings provide evidence for the buffering role of gratitude in a more frequent use of maladaptive CERS and depressive symptoms in cybervictimisation. The limitations and implications of the study are discussed.
In situ alloying: investigation of the melt pool stability during powder bed fusion of metals using a laser beam in a novel experimental set-up
Authors: Wimmer Andreas , Hofstaetter Fabian , Jugert Constantin , Wudy Katrin , Zaeh Michael F. 
Published: October 2021

AbstractThe limited access to materials for the Powder Bed Fusion of Metals using a Laser Beam (PBF-LB/M) is compensated by in situ alloying. Individual melt pool characteristics can be specifically influenced to improve the mechanical properties of the final part. However, conventional PBF-LB/M machines allow only limited access for detailed observation of the process zone and, in particular, the melt pool. This paper presents a methodology for systematically analyzing the melt pool in the cross section to determine the in situ variation of the melt pool depth. A custom PBF-LB/M test bench was devised to enable investigation of the process zone using high-speed infrared cameras. The image data were processed automatically using a dedicated algorithm. The methodology was applied to analyze the effect of additives on the melt pool stability. Stainless steel 316L powder was blended with the aluminum alloy AlSi10Mg by up to 20 wt.%. It was found that the blended powder significantly reduced the variation of the melt pool depth.