bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of Wenyang Huoxue decoction combined with Baduanjin exercise on the cardiac function and quality of life of patients with Yang deficiency coronary heart disease complicated with chronic heart failure
Authors: Zhou Miao , Lai Zhi-Kun , Tao Feng , Ni Hao-Xuan , Hu Xiao-Zhen 
Published: December 2024

Background:
Heart failure (HF) caused by coronary heart disease (CHD) is becoming increasingly common, and it still has a high morbidity and mortality rate. Previous studies have found that Wenyang Huoxue decoction combined with Baduanjin exercise can improve the cardiopulmonary function of patients with CHD, but it is not clear whether the heart function of patients with CHD complicated with HF can be improved by this treatment. This study aimed to evaluate the clinical effect of Wenyang Huoxue decoction combined with Baduanjin exercise on CHD complicated with HF.

Methods:
Patients with HF who received outpatient and inpatient treatment in the Shanghai Hospital of Traditional Chinese Medicine between 2019 and 2021 were enrolled in this study. The patients were randomly divided into a control group and a treatment group. N-terminal prohormone of brain natriuretic peptide, soluble growth stimulating express gene 2, stroke volume index, Minnesota Living with Heart Failure Questionnaire scores, and cardiac ultrasound were observed after 12 weeks of treatment.

Results:
100 patients were included, 3 were lost to follow-up, 49 in the treatment group and 48 in the control group. With a 30% reduction of N-terminal prohormone of brain natriuretic peptide as the primary endpoint, the effective rate of the treatment group was 57%, while that of the control group was 35%. In the meanwhile, stroke volume index and ejection fractions increased significantly, while soluble growth stimulating express gene 2 and Minnesota Living with Heart Failure Questionnaire scores were significantly decreased in the treatment group after treatment. There was no significant improvement trend in the control group.

Conclusions:
This study confirmed that treatment with Wenyang Huoxue decoction and Baduanjin exercise can improve the cardiac function and quality of life of patients with CHD complicated with HF and that it may have certain advantages in improving ventricular remodeling.
Effects of a 12-week Baduanjin regimen on biomechanical properties of axial muscle fascia in ankylosing spondylitis
Authors: Xie Yu , Zhang Qiuchi , Xin Dong , Wang Yue 
Published: December 2024

Background:
This study aims to evaluate the effects of a 12-week Baduanjin regimen on the biomechanical properties of axial muscle fascia in patients with ankylosing spondylitis (AS) through a randomized controlled trial, and to explore the underlying mechanisms of Baduanjin in AS treatment.

Methods:
Thirty patients with AS were randomly assigned to either the Baduanjin intervention group or the nonintervention group, with 15 patients in each group. The intervention group underwent a 12-week Baduanjin fitness program, while the nonintervention group continued their usual lifestyle and medication. Biomechanical parameters of muscle fascia, including muscle stiffness (N/m), muscle tension (frequency, Hz), and muscle elasticity (logarithmic decrement of oscillation amplitude), were measured at specified spinal locations using the MyotonPRO® soft tissue tester at baseline (week 0) and after 12 weeks (week 12).

Results:
The Baduanjin group exhibited significant improvements in muscle fascia stiffness, tension, and elasticity in the lumbar and cervical spine compared to the nonintervention group, with notable differences in lumbar stiffness and tension (P < .05). Postintervention, lumbar stiffness and tension were significantly reduced, and elasticity increased in the Baduanjin group, indicating beneficial effects on the biomechanical properties of axial muscle fascia in AS patients. No significant changes were observed in the nonintervention group. The Baduanjin group reported only mild muscle pain initially, which resolved with appropriate management, with no serious adverse effects noted.

Conclusion:
The findings suggest that Baduanjin significantly enhances the biomechanical properties of axial muscle fascia in AS patients. By improving these properties, Baduanjin may reduce mechanical stress, alleviate micro-damage and inflammation at attachment points, regulate downstream signaling pathways, and potentially limit new bone formation. This study provides scientific support for the use of Baduanjin in managing AS and offers a foundation for future research.
A single epidural administration of butorphanol combined with patient-controlled intravenous analgesia relieves postpartum contraction pain after cesarean section: A randomized clinical trial
Authors: Qiu Ling , Chen Xu-Hui , Fu Jia , Hua Lu , Fan Di , Zhang Ying-Ying , Wang Xiao-Bin 
Published: December 2024

Background:
Numerous studies have shown that butorphanol exerts an inhibitory effect on visceral pain. The aim of this study was to observe the effects of a single epidural administration of butorphanol combined with patient-controlled intravenous analgesia on postpartum uterine contraction pain after cesarean section.

Methods:
We randomly allotted 121 women undergoing cesarean section surgery procedure to 3 groups: 31 cases were excluded; and 90 cases were divided into group S (blank control, n = 30), group I (intravenous butorphanol, n = 30), and group E (butorphanol administered into the epidural cavity, n = 30). We then observed changes in the indices of uterine contraction pain and intraoperative stretch pain for the 3 groups.

Results:
(1) In terms of the uterine contraction pain, the visual analog scale scores of group I were lower than those for group S at 10 minutes (P = .001), 20 minutes (P < .001), 30 minutes (P < .001), 1 hour (P < .001), 2 hours (P < .001), and 4 hours (P < .001) after the epidural administration. The visual analog scale scores of group E were lower than those of group I at 10 minutes (P < .001), 20 minutes (P < .001), 30 minutes (P < .001), 1 hour (P < .001), 2 hours (P < .001), 4 hours (P < .001), and 6 hours (P < .001) after the administration. (2) In terms of intraoperative traction reactions, sedation, and comfort during the operation, group E was superior to groups S and I at any time points (all P < .043).

Conclusions:
Butorphanol single epidural administration combined with intravenous patient-controlled analgesia can effectively reduce the pain of uterine contraction and intraoperative traction reaction and improve perioperative comfort of the parturient.
Association between potential factors and dry eye disease: A systematic review and meta-analysis
Authors: Yang Kuiliang , Wu Shangcao , Ke Lan , Zhang Han , Wan Shanshan , Lu Mingzhi , Mao Jiewen , Gao Yuelan , Yang Yanning , Xing Yiqiao , Yang Wanju 
Published: December 2024

Background:
The 2017 TFOS DEWS II report provided an overview of the epidemiology of dry eye disease (DED) and identified several potential risk factors. This study aimed to conduct a meta-analysis on these potential risk factors.

Methods:
A comprehensive systematic search was conducted in PubMed, Embase, Web of Science, and Cochrane Library databases to include observational studies. Two researchers independently extracted adjusted odds ratios (AORs) and their 95% confidence intervals (CIs), and a random-effects model was used to combine the data. Results were reported using odds ratios (ORs) and their 95% CIs.

Results:
The meta-analysis results showed that the risk factors for DED were smoking (OR 1.18, 95% CI 1.07–1.29), alcohol consumption (OR 1.18, 95% CI 1.03–1.35), rosacea or acne (OR 1.96, 95% CI 1.56–2.45), allergic conjunctivitis (OR 4.59, 95% CI 3.38–6.23), refractive surgery (OR 1.78, 95% CI 1.05–3.00), diabetes (OR 1.14, 95% CI 1.06–1.22), thyroid disease (OR 1.57, 95% CI 1.36–1.82), viral infections (OR 1.54, 95% CI 1.33–1.78), anxiety (OR 2.39, 95% CI 1.30–4.39), depression (OR 1.59, 95% CI 1.39–1.82), post-traumatic stress disorder (OR 1.43, 95% CI 1.42–1.45), and stress (OR 1.59, 95% CI 1.24–2.05). However, there was no significant association between Hispanic ethnicity, menopause, past smoking, current smoking, multivitamin use, and DED.

Conclusion:
These findings provide valuable insights for further research on the prevention and treatment of dry eye disease.
Repeated tube exposure due to masked herpes zoster ophthalmicus after Ahmed valve implantation in an eye with neovascular glaucoma: A case report
Authors: Tanabe Hirotaka , Nakakura Shunsuke , Shimizu Yoshie , Maruoka Sachiko , Shojo Tomohiro 
Published: December 2024

Rationale:
Herpes zoster ophthalmicus (HZO) occurs after the reactivation of latent varicella-zoster virus (VZV) present within the sensory spinal or cerebral ganglia and sometimes causes ocular inflammatory diseases, including neovascular glaucoma (NVG), which is one of the most devastating sequelae of virus-associated uveitis. In NVG, the synechial angle ultimately closes due to the contraction of proliferating myofibroblasts, which often requires glaucoma filtration surgery, including Ahmed glaucoma drainage device implantation, to maintain optimum intraocular pressure (IOP). Although tube exposure from the conjunctiva is a complication of glaucoma implant surgery, a case in which a glaucoma tube implant was repeatedly exposed due to masked HZO in a postoperative eye with NVG has not been reported.

Patient concerns:
A 72-year-old male with NVG in his left eye ultimately underwent Ahmed glaucoma valve implantation with sulcus fixation for uncontrolled IOP. Before surgery, acyclovir ophthalmic ointment had been applied to treat a suspected VZV infection, but the regimen was discontinued because an aqueous humor sample tested negative for VZV according to polymerase chain reaction. Postoperatively, the patient’s IOP dramatically decreased without any need for glaucoma eye drops. However, the tube was exposed when the overlying conjunctiva and allogeneic scleral grafts disintegrated.

Diagnoses:
Although the tube was covered with different types of tissues, including an allogeneic corneal graft and an autogenous conjunctival graft from the same eye, the grafts completely disintegrated again. Covering the tube with another allogeneic corneal graft and an autogenous free conjunctival graft from the contralateral eye also failed, with gradual disintegration of these tissues. During the observation period, severe HZO with Hutchinson sign and clearly demarcated pseudodendritic corneal ulceration were noted.

Interventions:
After thorough consideration, we cut and removed the tube to avoid possible scleral perforation due to prolonged inflammation.

Outcomes:
Fortunately, the patient’s IOP was controlled by resuming the continuous daily application of antiviral ointment and repeatedly injecting anti-vascular endothelial growth factor for rubeosis regularly afterward.

Lessons:
The possibility of VZV reactivation should always be considered in cases of tube exposure due to an unknown cause after Ahmed valve implantation in an eye with NVG.
Clinical efficacy analysis of cosmetic suture technique combined with tension reducer in the treatment of facial skin trauma
Authors: Gao Ya , Wang Yalin , Li Wenbo , Wu Fenglian 
Published: December 2024

Background:
This study aims to observe the clinical efficacy of cosmetic suture technique combined with tension reducer in the treatment of facial skin trauma and provide more sequential treatments for facial skin trauma.

Methods:
Sixty patients with facial skin trauma who visited our department from January 2023 to January 2024 were selected as the research subjects. Patients who received cosmetic sutures combined with tension reducers were selected as the observed group (n = 30), while patients who received simple cosmetic sutures were selected as the control group (n = 30). Follow-up at 1, 3, and 6 months after surgery to compare the condition of scar formation (using the Vancouver scar rating scale), scar width, and patient satisfaction between the 2 groups.

Results:
After 1, 3, and 6 months of follow-up, the total score of Vancouver scar rating scale in the observed group was lower than that in the control group (P < .05); The average postoperative scar width in the observed group was (0.72 ± 0.07 mm), which was narrower than that in the control group (1.03 ± 0.12 mm) (P < .05). The satisfaction rate of patients in the observed group was 93.33%, which was higher than 73.33% in the control group (P < .05).

Conclusion:
The combination of cosmetic sutures and tension reducer in the treatment of facial skin trauma can effectively improve the scar condition, narrow the scar width, and greatly improve patient satisfaction. It is worth popularizing in the treatment of facial skin trauma.
Network meta-analysis on 4 types of traditional Chinese medicine injections in the treatment of senile severe pneumonia
Authors: Tu Yangli , Wu Changbing , Chen Liang , Cen Yinzhi , Liu Jie 
Published: December 2024

Background:
As the global population ages, senile severe pneumonia has become a prominent health challenge. Conventional drug treatments have limitations. Meanwhile, 4 types of traditional Chinese medicine injections have shown potential. Thus, it’s necessary to use network meta-analysis to comprehensively evaluate their combined effect with conventional drugs on this disease.

Methods:
China National Knowledge Infrastructure, VIP shop Database, WanFang database, PubMed, and Cochrane Library were included in randomized controlled studies on traditional Chinese medicine injections for the treatment of senile severe pneumonia from the establishment of the library to January 2023. The literature was assessed for risk of bias using the Review Manager 5.3 software. Study outcome indicators were statistically analyzed using Stata 14.0 and Review Manager 5.3 software.

Results:
Thirty-three studies were included with a total of 2598 patients. The main outcome indicator was the clinical effective rate. Secondary outcome indicators were white blood cell count, procalcitonin, and C-reactive protein. The results of network meta-analysis showed that clinical efficacy of Reduning injection combined with conventional drug had the better effect. Xiyanping injection combined with conventional drug could better reduce white blood cell and C-reactive protein indicators. Xuebijing injection combined with conventional drug had better ability to reduce procalcitonin.

Conclusion:
Reduning injection, Xiyanping injection, Tanreqing injection, and Xuebijing injection combined with conventional drugs in the treatment of senile severe pneumonia can improve the clinical effect.
Sézary syndrome mimicking Steven–Johnson syndrome: A case report
Authors: Fan Sheng-Wei , Lai Kuan-Ming 
Published: December 2024

Rationale:
Sézary syndrome is a rare and subtype of non-Hodgkin T cell lymphomas. It typically presents as papules, macules, nodules, or ulcers, frequently accompanied by lymphadenopathy and systemic symptoms. This study describes uncommon clinical and diagnostic features to distinguish Sézary syndrome from serious skin and mucous membrane disorders through a detailed case report and comprehensive literature review.

Patient concerns/Diagnosis/Intervention/Outcomes:
A 70-year-old female patient was diagnosed with progressive Sézary syndrome associated with extensive cutaneous scaly and ulcerative lesions after 5 cycles of anthracycline-based chemotherapy which is initially misleading to Steven–Johnson syndrome (SJS). SJS was clinically excluded due to no mucosal involvement. She received a single agent of steroid as a lymphoma salvage treatment due to poor performance and nutrition status. Facial and left arm skin biopsy revealed T lymphoma cells infiltrating the upper dermis. Unfortunately, she died due to progressive lymphoma disease and upper gastrointestinal bleeding.

Lessons:
Unlike mycosis fungoides, Sézary syndrome involves more than bathing suit areas of skin and it may present with scaly, ulceration, or even hemorrhagic bullae and Sézary cells in peripheral blood. Sometimes, it’s hard to differentiate from SJS or toxic epidermal necrolysis (TEN). Mucosa involvement is a crucial feature shown in patients with SJS/TEN.
Association of prognostic nutritional index with long-term survival in lung cancer receiving immune checkpoint inhibitors: A meta-analysis
Authors: Wang Lei , Long Xingxia , Zhu Ying , Luo Ailin , Yang Mei 
Published: December 2024

Background:
This meta-analysis aimed to identify the association of prognostic nutritional index (PNI) with long-term survival in lung cancer patients who received the immune checkpoint inhibitors.

Methods:
The Medline, CNKI, EMBASE, and Web of Science databases were searched up to August 20, 2023. Progression-free survival (PFS) and overall survival (OS) were main outcomes and hazard ratios (HRs) and 95% confidence intervals were combined. Subgroup analysis stratified by the pathological type [non-small cell lung cancer (NSCLC) vs small cell lung cancer (SCLC)], previous treatment history and combination of other treatment was performed.

Results:
Twenty-two available studies with 2550 patients were included. Pooled results demonstrated that lower PNI was related to worse PFS (HR = 0.51, P<.001) and OS (HR = 0.43, P<.001). Furthermore, subgroup analysis based on the pathological type (non-small cell lung cancer: HR = 0.52, P<.001 for PFS, HR = 0.41, P<.001 for OS; small cell lung cancer: HR = 0.41, P = .007 for PFS, HR = 0.44, P = .007 for OS), previous treatment history (first-line treatment: HR = 0.67, P<.001 for PFS, HR = 0.52, P<.001 for OS) and combination of other treatment (No: HR = 0.54, P<.001 for PFS, HR = 0.43, P<.001 for OS; Yes: HR = 0.63, P<.001 for PFS, HR = 0.51, P<.001) showed similar findings.

Conclusion:
PNI is significantly associated with long-term survival in immune checkpoint inhibitors treated lung cancer and patients with lower PNI are more likely to experience poorer prognosis.
Synchronous pancreatic adenocarcinoma and duodenal mucosa‑associated lymphoid tissue lymphoma: A case report
Authors: Lee Yong-Pyo , Lee Jun Su , Kim Hong-Sik , Han Hye Sook , Lee Jisun , Woo Chang Gok , Lee Ok-Jun , Son Seung-Myoung 
Published: December 2024

Rationale:
Duodenal mucosa-associated lymphoid tissue (MALT) lymphoma is a rare condition. Simultaneous presence of pancreatic ductal adenocarcinoma along with duodenal MALT lymphoma has not been documented in the scientific literature. We report an exceptionally rare case of synchronous duodenal MALT lymphoma and pancreatic ductal adenocarcinoma.

Patient concerns:
A 75-year-old man was referred to our hospital with dyspepsia and weight loss.

Diagnoses:
Esophagogastroduodenoscopy was performed, revealing synchronous tumor comprising pancreatic ductal adenocarcinoma and MALT lymphoma of the duodenum.

Interventions:
Given that the pancreatic carcinoma would be the primary determinant of prognosis, we prioritized treatment of the pancreatic carcinoma. Consequently, we performed a Whipple operation first. Post-operative pathologic examination revealed metastasis of pancreatic cancer to peri-pancreatic lymph nodes, whereas the MALT lymphoma was localized to the duodenum; therefore, only adjuvant chemotherapy for pancreatic cancer was performed.

Outcomes:
To date, the patient has had no recurrence of either the pancreatic cancer or the MALT lymphoma.

Lessons:
To the best of our knowledge, this is the first case to be reported. Awareness of this co-occurrence may help diagnosis and management of similar cases.
Three Decades of Outpatient Plastic Surgery Safety: A Review of 42,720 Consecutive Cases
Authors: Rohrich Rachel , Brown Tal , Brown Stav , Burns John , Jejurikar Sameer , Meade Ricardo , Rohrich Rod J. 
Published: December 2024

Background:
Outpatient plastic surgery offers cost-effective solutions and enhanced privacy but demands careful patient assessment for suitability and vigilant anticipation of adverse events. This study provides recommendations to enhance patient safety in outpatient settings by analyzing over 40,000 consecutive cases spanning across three decades.

Methods:
We retrospectively reviewed all consecutive cases completed by board-certified plastic surgeons at an accredited outpatient surgical center between 1995-2023. Patient demographics, operative details, and postoperative complications were recorded to determine risk factors for complications and inpatient admissions. A subgroup-analysis for procedures of the face, breast and body was also performed.

Results:
42,720 consecutive cases were performed with an overall complication rate of 0.74 percent (n=318). Patients who experienced a VTE or an inpatient transfer, had a higher BMI (p<0.05), longer operative duration (p<0.05) and were more likely to have undergone combined procedures (p<0.05) compared to those who did not. Undergoing a combined procedure was the strongest predictive factor for VTE and inpatient admissions (OR=12.65, OR=3.73; p<0.05), followed by longer operative time (OR=1.45, OR=1.32; p<0.05).

Conclusion:
To our knowledge, this is the largest long-term private practice plastic surgery study in accredited outpatient settings spanning almost 30 years, further confirming that outpatient plastic surgery can be done in a consistent and safe manner with proper preoperative evaluation and patient optimization. Postoperative monitoring should be considered for high-risk patients, particularly those with a BMI exceeding 26 kg/m², operative times surpassing 3 hours, lipoaspirate volumes greater than 3 liters, and patients undergoing combined procedures - particularly in cases involving abdominoplasty.
The versatility of the Supinator to Posterior Interosseus Nerve (SPIN) transfer: Indications and outcomes, a Case Series
Authors: George Samuel , Kulenkampff Chane , Chaudhry Tahseen , Duraku Liron S. , Power Dominic M. 
Published: December 2024

Background:
Transfer of the supinator motor branches to the posterior interosseous nerve (SPIN) was first described as a reliable method of restoration of digit extension in cases of paralysis when there is retained function in the 5th and 6th cervical nerve roots with loss of function in the 8th cervical nerve root.

Methods:
We performed a retrospective review of all the SPIN transfers that were performed in our unit which included 16 limbs in 14 patients over a 6-year period. The median age was 49 years (range 22-74). The average follow-up period was 15 months (range 6-24 m). Aetiology included spinal cord injury (SCI) in 5, plexus root avulsion in 3, degenerate spondyloradiculopathy in 3 and the final three patients had paralysis from oncological resection, inflammatory and compressive neuropathy respectively.

Results:
Functional digit extension (MRC grade 3 and above) was achieved in 12/16 limbs. Patients with degenerative spine lesions had the worst outcome with a median of MRC grade 2 with a median time to surgery of 20 months (average age of 67), compared to 13 months in the SCI group (average age 32.8) and four months in the BPI group (average age 34.6).

Conclusions:
The SPIN transfer may be safely performed in a wide spectrum of pathologies including brachial plexus injuries, spinal cord injuries and neuritis. However, in degenerative spondyloradiculopathy we report inferior outcomes, which may be due to late referral, chronic denervation, possible involvement of the donor nerve and an older age group and potentially diminished rehabilitation and neural plasticity potential.