bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensitivity analysis and prediction of water supply and demand in Shenzhen based on an ELRF algorithm and a self-adaptive regression coupling model
Authors: Liu Xin , Sang Xuefeng , Chang Jiaxuan , Zheng Yang , Han Yuping 
Published: August 2021

AbstractGiven that sensitive feature recognition plays an important role in the prediction and analysis of water supply and demand, how to conduct effective sensitive feature recognition has become a critical problem. The current algorithms and recognition models are easily affected by multicollinearity between features. Moreover, these algorithms include only a single learning machine, which exposes large limitations in the process of sensitive feature recognition. In this study, an ensemble learning random forest (ELRF) algorithm, including multiple learning machines, was proposed to recognize sensitive features. A self-adaptive regression coupling model was developed to predict water supply and demand in Shenzhen in the next ten years. Results validate that the ELRF algorithm can effectively recognize sensitive features compared with decision tree and regular random forest algorithms. The model used in this study shows a strong self-adaptive ability in the modeling process of multiple regression. The water demand in Shenzhen will reach 2.2 billion m3 in 2025 and 2.35 billion m3 in 2030, which will exceeded the water supply ability of Shenzhen. Furthermore, three scenarios are designed in terms of water supply security and economic operation, and a comparative analysis is performed to obtain an optimal scenario.
Removal of pentachlorophenol from contaminated wastewater using phytoremediation and bioaugmentation processes
Authors: Werheni Ammeri Rim , Kraiem Khadija , Riahi Khalifa , Eturki Saiefeddine , Hassen Wafa , Mehri Ines , Hassen Abdennaceur 
Published: August 2021

Abstract
The phytoremediation procedure was conducted by Lemna gibba (L) and Typha angustifolia (T) and the bioaugmentation procedure used P. putida HM627618. The ability of the selected P. putida HM627618 to tolerate and remove PCP (200 mg L−1) was measured by high performance liquid chromatography analysis and optical density at 600 nm. Five different experiments were conducted in secondary treated wastewater for PCP testing removal (100 mg L−1) including two phytoremediation assays (T + PCP; L + PCP), three bioaugmentation-phytoremediation assays (T + B + PCP; L + B + PCP; L + T + B + PCP) and a negative control assay with PCP. Various analytical parameters were determined in this study such as bacterial count, chlorophylls a and b, COD, pH and PCP content. The main results showed that the average PCP removal by P. putida HM627618 was around 87.5% after 7 days of incubation, and 88% of PCP removal was achieved by treatment (T + B) after 9 days. During these experiments, pH, COD and chloride content showed a net increase in all treatments. The chlorophylls a and b in case of (T) and (L) Chlorophylls a and b for T and L phytoremediation showed a decrease with a value less than 10 μg/mg of fresh material after 20 days of cultivation.
Cerebral Microbleeds and White Matter Hyperintensities are Associated with Cognitive Decline in an Asian Memory Clinic Study
Authors: Gyanwali Bibek , Lui Benedict , Tan Chuen S. , Chong Eddie J.Y. , Vrooman Henri , Chen Christopher , Hilal Saima 
Published: August 2021

Background:
Cerebral Small Vessel Disease (SVD); lacunes, Cerebral Microbleeds (CMBs),
and White Matter Hyperintensities (WMH) have a vital role in cognitive impairment and dementia.
SVD in lobar location is related to cerebral amyloid angiopathy, whereas SVD in a deep location with
hypertensive arteriopathy. It remains unclear how different locations of SVD affect long-term cognitive
decline. The present study aimed to analyse the association between different locations and severity
of SVD with global and domain-specific cognitive decline over the follow-up interval of 3 years.

Methods:
We studied 428 participants who had performed MRI scans at baseline and at least 3 neuropsychological
assessments. Locations of lacunes and CMBs were categorized into strictly lobar,
strictly deep and mixed-location, WMH volume into anterior and posterior. The National Institute of
Neurological Disorders and Stroke-Canadian Stroke Network Harmonization Neuropsychological
Battery was used to assess cognitive function. To analyse the association between baseline location and
severity of SVD with cognitive decline, linear regression models with generalized estimated equations
were constructed to calculate the mean difference, 95% confidence interval and two-way interaction
factor between time and SVD.

Results:
Increased numbers of baseline CMBs were associated with a decline in global cognition as
well as a decline in executive function and memory domains. Location-specific analysis showed similar
results with strictly lobar CMBs. There was no association with strictly deep and mixed-location
CMBs with cognitive decline. Baseline WMH volume was associated with a decline in global cognition,
executive function and memory. Similar results were obtained with anterior and posterior WMH
volumes. Lacunes and their locations were not associated with cognitive decline.

Conclusion:
Strictly lobar CMBs, as well as WMH volume in anterior and posterior regions, were
associated with cognitive decline. Future research focuses are warranted to evaluate interventions that
may prevent cognitive decline related to SVD.
Cardiovascular Disease in Patients with Diabetes: A Comparison of Professional Society Guidelines
Authors: Sarkar Sudipa , Salazar Ilton M. Cubero , Tibuakuu Martin , Blumenthal Roger S. 
Published: August 2021

Abstract:
In this review, we compare major points given in the 2021 American Diabetes Association
and the 2020 American Association of Clinical Endocrinologists/American College of Endocrinology
guidelines, in particular, the assessment and management of cardiovascular risk in patients
with diabetes with a focus on dyslipidemia, blood pressure, and pharmacotherapy in diabetes.
Assessing the Real-time Influence of Racism-Related Stress and Suicidality Among Black Men: Protocol for an Ecological Momentary Assessment Study
Authors: Adams Leslie , Igbinedion Godwin , DeVinney Aubrey , Azasu Enoch , Nestadt Paul , Thrul Johannes , Joe Sean 
Published: August 2021

Background
Suicide is the third leading cause of death among Black adults aged 18-35 years. Although men represent a majority of suicide deaths among Black adults, less is known regarding the extent to which unique cultural stressors, such as racism-related stress (eg, racial discrimination), are salient in exacerbating suicide risk among Black men. Moreover, few studies examine the daily influence of racism-related stressors on suicide outcomes using real-time smartphone-based approaches. Smartphone-based mobile health approaches using ecological momentary assessments (EMA) provide an opportunity to assess and characterize racism-related stressors as a culturally sensitive suicide risk factor among Black young adult men.

Objective
The goal of this study is to describe a protocol development process that aims to capture real-time racism-related stressors and suicide outcomes using a smartphone-based EMA platform (MetricWire).

Methods
Guided by the Interpersonal Theory of Suicide (ITS), we developed a brief EMA protocol using a multiphased approach. First, we conducted a literature review to identify brief measures previously used in EMA studies, with special emphasis on studies including Black participants. The identified measures were then shortened to items with the highest construct validity (eg, factor loadings) and revised to reflect momentary or daily frequency. Feasibility and acceptability of the study protocol will be assessed using self-report survey and qualitative responses. To protect participants from harm, a three-tier safety protocol was developed to identify participants with moderate, elevated, and acute risk based on EMA survey response to trigger outreach by the study coordinator.

Results
The final EMA protocol, which will be completed over a 7-day period, is comprised of 15 questions administered 4 times per day and a daily questionnaire of 22 items related to sleep-related impairment and disruption, as well as racism-related stress. Study recruitment is currently underway. We anticipate the study will be completed in February 2023. Dissemination will be conducted through peer-reviewed publications and conference presentations.

Conclusions
This protocol will address gaps in our understanding of Black men’s suicide outcomes in the social contexts that they regularly navigate and will clarify the temporal role of racism-related stressors that influence suicidal outcomes.

International Registered Report Identifier (IRRID)
PRR1-10.2196/31241
La enseñanza, lo femenino y la vida. Reseña del libro: Foucault, M. (2020) La sexualidad. Seguido de El discurso de la sexualidad
Authors: Valle Vázquez Ana María 
Published: August 2021

Hasta ahora tenemos cuatro libros de Foucault dedicados a la experiencia ética del sexo: en los griegos con la aphrodisia, en los cristianos con la carne y en los modernos con la sexualidad.Hoy en 2020 celebramos el tomo cero titulado La sexualidad. Seguido de El discurso de la sexualidad, que trata de dos cursos impartidos por Foucault, el primero en 1964 y el segundo en 1969. La pregunta nodal y que puede articular a ambos cursos es: ¿qué es la sexualidad en nuestra cultura?
Niosomes as Nano-carrier Based Targeted Drug Delivery System
Authors: Joy Chanchal , Nair Smitha K. , Krishna Kumar K , Dineshkumar B 
Published: August 2021

Niosomes are considered as novel nano-carrier in the drug delivery systems. These are much more stable than other nano-carriers like liposomes and nanoparticles. It is an example for targeted and control release of medication. The drug is entrapped into lipid core so that it prevents the drug from leaching. Here the drug will be targeted only to the desired cell/tissue and not to the non-targeted cells. By giving this formulation we can thereby reduce the dose of the drug and toxicity. This review article mainly emphasizes on the potential applications of niosomes in targeted drug delivery system.
Keywords: niosomes, nanocarriers, targeted drug delivery.
Experimental Design: Approaches and Applications in Development of Pharmaceutical Drug Delivery System
Authors: Supare Vinanti , Wadher Kamlesh , Umekar Milind 
Published: August 2021

Conventionally, all the delivery systems have been prepared by methodology of trial and error concept by manipulating one variable at a Time, but attainment of optimal formulation is not achievable. The systematic approach Design of Experiments (DoE) enables researchers to provide appropriate outline to develop a best optimized delivery system. Optimization techniques using DoE helps to provide effective and economical analytical tools to find the perfect solution for a particular problem. In screening designs, there is large number of screening factors in minimum number of experiments and beneficial to minimize the variables in a desired size therefore further experimentation may be performed easily by using these variables. Experimental designs and optimization techniques are the tools which are systematically used to categorize various types of problems that may influence development of pharmaceutical delivery system. Use of experimental design is the best approach to the screening and optimization of experimental factors. In the present review article we have focused on application of practically applicable experimental designs and optimization techniques for the development of quality and efficacious of pharmaceutical formulations such as, nanoparticles, Phytosomes, microspheres, liposomes, micells, films, nanostructured lipid carriers and tablets and which type of factors to be considered while optimization are also discussed.
Keywords: Experimental design, Optimization, Applications, Drug delivery, Phytosomes, Nano delivery System.
Transdermal patches: an emerging mode of drug delivery system in pulmonary arterial hypertension
Authors: Dubey Rupal , Pothuvan Umadoss 
Published: August 2021

Transdermal Patches have been contributing important part to the pharmaceutical industry and medical practice by providing advances in delivery of treatment with existing and novel drugs. Transdermal drug delivery system has made great contribution in the medical practices but many researches are undergoing to achieve its full potential. Transdermal drug delivery system was came into existence to overcome difficulties of drug delivery especially oral route. Transdermal drug delivery refers to means of delivering drugs through the surface of the skin for local or systemic treatment. The drug functions after absorption through skin into the systemic circulation via capillary action at certain rate. Transdermal patches are now widely used as topical and transdermal delivery systems. These patches are a significant result of advancements in skin science, technology, and knowledge, which have been created via trial and error, clinical observation, and evidence-based investigations dating back to the earliest human records. A transdermal patch is a medicated adhesive patch that is applied to the skin and used to deliver a precise amount of medicine into the bloodstream via the skin. A benefit of transdermal medication administration over other forms of delivery systems such as oral, topical, intravenous (i.v.), intramuscular (i.m.), and so on is that it is non-invasive. Transdermal patches provide medication to the patient in a regulated manner, either by a porous membrane covering a reservoir of medication or by body heat melting tiny layers of drug contained in the adhesive. This review article covers the basics of transdermal patches, such as the many types of patches, how they're made, and what factors influence them, among other things.
Keyword: Skin Delivery, Transdermal Drug Delivery System, Transdermal Excipients, Pulmonary Arterial Hypertension, Sildenafil Citrate.
Phytochemical screening, mineral analysis and evaluation of the diuretic effect of aqueous extract of Pericopsis laxiflora from male Sprague Dawley rats
Authors: DOUKOUROU Dahiro Noel , KAMOU Richard , Bamba Bourahima , Ouattara Karamoko 
Published: August 2021

Pericopsis laxiflora is among the medicinal plants used by the traditional practitioner in the treatment of many diseases. However, data on its diuretic power are lacking. Moreover, the effect of the preparation of traditional galenic formulations on the composition of phytocompounds and essential minerals and metals is unknown. The aim of this study was to show the effect of treatment on the phytocompounds and minerals composition and to evaluate diuretic effect of Pericopsis laxiflora aqueous axtracts. The tube characterization reactions revealed flavonoids, sterols, terpenes, catechin tannins polyphenols and saponins in aqueous extracts. Gallic tannins and quinones are absent, All compounds were generally present in same proportions in two aqueous extracts. Chemical analysis of all aqueous extracts by atomic absorption spectrometry (AAS) showed effect of model extraction on minerals. Copper (0.3116 mg / 100g), magnesium (260.7 mg /100 g), selenium (0.00904 mg /100 g), zinc (4.52 mg /100 g), manganese (75.029 mg /100g) are more concentrated in maceration than a decoction. For decoction of same plant, the situation is reversed with sodium (58.6mg /100g), calcium (12670 mg/100g), iron (18.51mg/100g) and potassium (2781 mg /100g). For pharmacological investigation, 32 rats Sprague Dawley male weighing 385-433g are isolated each in metabolic cages from 6 pm to 8am and treated with 100mg/kg of Pericopsis laxiflora aqueous extracts. From 8am to 2pm the animals received only tap water in metabolic cages. The volumes of water intake and urine were not significantly different in the two groups (treated and untreated).The diuretic effect was not observed with 100mg/kg (b/w) . In addition polyphenols, flavonoids, saponins and minerals such as potassium, magnesium and selenium are indicators of the vasodilatory and cardioprotective functions of Pericopis laxiflora aqueous extracts. The prescription of these extracts in traditional medicine must take into account the toxicity of the plant associated with a calcium and manganese content.
Keywords: Pericopsis laxiflora, dueresis, decocted extract, macerated extract, minerals, Rats Sprague Daweley
Systematic Review of Plants Used Against Respiratory Diseases Related to COVID-19 in Africa
Authors: Agbor Gabriel A , Ndjib Rosette 
Published: August 2021

Background: Respiratory disorders are known to affect the airways including the nasal passages, bronchi and lungs causing blockages. The advent of COVID-19 has further aggravated the complications of the respiratory systems where conventional medicine is not reachable or affordable by the majority poor in Africa. Hence, the over 80% of the African population who turn to traditional medicine for their primary health care.
Objective: This review is aimed to identify plants directed against respiratory diseases which can be useful in the fight against COVID-19.
Methodology: Scientific articles selected in this study span the last ten years (2011-2021). Keywords such as “ethnobotany in Africa”, “ethnobotany and respiratory diseases” “medicinal plants and respiratory diseases”, “traditional medicine and COVID-19” were searched in open access search engines such as: Science Direct, Research Gate, Google Scholar, Pubmed, Web of Science, Scopus. The ethnobotanical indices were then calculated using Microsoft excel to determine the plants with the most therapeutic potential to be considered for the local management of COVID-19.
Results: Data obtained were classified according to country of origin of the author of the publication, the botanical family and the respiratory pathology being treated. Thirteen (13) references were finally selected with the represented country being Benin Republic. One hundred and forty-three plant species belonging to 60 families were registered. The most recurrent families were the Fabaceae and Lamiaceae (18 citations each). The plants in these families were used for the management of fifteen diseases and / or symptoms relating to the respiratory system. The most cited plants were: Ocimum gratissimum L. (4 citations), Entandrophragma cylindrium (Sprague), Scyphocephalium ochocoa Warb., Rubia cordifolia and Allium sativum L. (3 citations each).
Conclusion: Based on the data obtained in this review Ocimum gratissimum stands out as the most used plant for the treatment of respiratory disorders.
Keywords: Respiratory diseases, Medicinal plants, COVID-19
Biochemical Evaluation of Some Liverworts Pigments and Phenolics
Authors: Khalkar K.M. , Kadam V.B. 
Published: August 2021

Three genera viz. Riccia, Plagiochasma and Targionia were studied biochemically. It was found that amount of total chlorophylls and polyphenol content is more in Targionia as compared to Riccia and Plagiochasma Flavonoids are also studied adopting chromatography technique and when the spots viewed under UV were found to be of similar type in Riccia, and Plagiochasma, whereas Targionia showed the present of only one spot ,identical to the second spot isolated in Riccia, and Plagiochasma
Keywords: Biochemical, Riccia, Plagiochasma, Targionia, pigments, phenolics.
Antiulcerogenic effect of Methanolic Root Extract of Berberis lycium Linn by Pylorus ligation and Ethanol induced Ulceration
Authors: Namdeo Priyanka , Pandole Madhuri , Singh Priti 
Published: August 2021

Background: Gastric ulcer is one of the most prevalent gastrointestinal disorders, which affects approximately 5-10% of people during their life. In recent years, abundant work has been carried out on herbal medicine to clarify their potential efficacy in gastric ulcer prevention or management. The present study was carried out to evaluate the antiulcer activity of the methanolic root extract of Berberis lycium in albino rats.
Method: The methanolic root extract of Berberis lycium was prepared by hot extraction method. Anti-ulcer activity was evaluated and method employed was pylorus ligation and ethanol induced in albino rats. Preliminary methanolic extract of Berberis lycium was subjected to the acute oral toxicity study according to the OECD guideline no. 425. Animals were divided into four groups of six animals each. The animals of Group I served as normal control (vehicle) which received distilled water. Group II and III received 250 mg/kg and 500 mg/kg of methanolic root extract, respectively. In pylorus ligation induced ulcer model, various parameters were studied viz. gastric volume, pH, total acidity, free acidity, and ulcer index. Ulcer index and percentage inhibition of ulceration was determined for ethanol induced ulcer model. Group IV received Ranitidine at 50 mg/kg was used as the standard drug. Pretreatment of methanol root extract of Berberis lycium showed significant (P˂0.05) decrease in the gastric volume, total acidity and free acidity. However, pH of the gastric juice was significantly increased only at higher dose 500 mg/kg. It showed also significant (P˂0.05) decrease in number of ulcers and ulcer score index in pylorus ligation and ethanol induced ulceration models.
Results: The methanol root extract of Berberis lycium showed a significant reduction in the total acidity, free acidity and acid volume. The efficacy of plant extract at high dose was comparable with the standard drug Ranitidine.
Conclusion: Our study results support the ethnomedical use of root of Berberis lycium.
Keywords: Antiulcer activity, Berberis lycium, Pylorus ligation, Ranitidine, Ulcer Index.
Evidence-Based Therapeutic Benefits of Cupping Therapy (Ḥijāma): A Comprehensive Review
Authors: Kouser Hina V , Nayab Mohd , Tehseen Ayesha , Mahfooz Shaista , Ruqaiyya Baig , Anwar Mohd 
Published: August 2021

Ilaj bi’l tadbeer (regimenal therapy) is one of the preferred treatment methods used in Unani system of medicine since ancient times. Ḥijāma is one of the effective modalities of treatment in Ilaj bi’l tadbeer. It is a unique therapeutic procedure in which cup like vessels are placed on the body surface by creating a vacuum to either let out blood from below the skin surface or just plain suction without bloodletting. The objective of this comprehensive review paper is to address the claims of Unāni physicians and clinical studies conducted on the efficacy of Ḥijāma. Various published clinical trials showed the efficacy of Ḥijāma in the management of a number of diseases. Though, the effect showed by some clinical trials was short term. Hence, it is suggested that rigorous, well-designed, controlled, randomized and long duration follow up clinical trials on large sample size are to be conducted by trained clinicians or researchers to establish the efficacy of Ḥijāma in the management of various diseases.
Keywords: Ilaj bi’l tadbeer, Ḥijāma, Therapeutic Benefits
Biochemical profile of Boswellia serrata and Rhus mysorensis
Authors: Kadam U.B. , Khalkar K.M. , Kadam V.B. 
Published: August 2021

The seasonal variation of proteins and amino acids content have been investigated from leaves, wood and bark of Boswellia serrata and Rhus mysorensis are the medicinal important plant of Laling forest Dhule district of Maharashtra. Comparative account of protein content of leaves, wood and bark of Rhus mysorensis showed higher level (range 1.897 to 2.754 mg/g dry wt.) than Boswellia serrata (range 1.846 to 2.312 mg/g dry/wt.). Comparative account of amino acid content of leaves, wood and bark of Rhus mysorensis showed higher level (range 0.911 to 1.074 mg/g dry wt.) than Boswellia serrata (range 0.745 to 0.896 mg/g dry wt.).
Keywords: Protein, amino acid , Boswellia serrata and Rhus mysorensis