bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevention of incipient carious lesions with various interventions during fixed and removable orthodontic treatment. A systematic review and meta-analysis
Authors: Mathews Justin , Schneider Paul M. , Horvath Anita , Manton David J. , Silva Mihiri 
Published: September 2021

AbstractObjective: To systematically review and quantify the effectiveness of interventions in reducing caries development during orthodontic treatment and evaluate the quality of evidence for the development of clinical guidelines.Materials and methods: A comprehensive literature search of the Cochrane, EMBASE and MEDLINE databases was conducted to identify eligible randomised controlled trials (RCTs). The risk of bias was assessed using the Cochrane risk of bias (RoB 2) tool. In order to facilitate the development of clinical guidelines, the quality of the evidence was assessed using Grading of Recommendations, Assessment, Development and Evaluation (GRADE).Results: A total of 18 RCTs were included in the qualitative synthesis, of which 10 had a high risk of bias, and eight had minor concerns. Three RCTs that investigated the efficacy of fluoride interventions during fixed orthodontic treatment were included in the quantitative synthesis. The pooled effect size resulted in a risk reduction of 0.23 (95% CI: -0.35, -0.11,p< 0.001) in the intervention group compared to controls. The GRADE evaluation identified the evidence as moderate due to the limited number of RCTs and moderate heterogeneity (I-squared statistic of 49.3%).Conclusions: Although fluoride is the most effective evidence-based preventive intervention during orthodontic treatment, large RCTs are required to provide high quality evidence. Further studies are needed to evaluate the caries preventive effects of oral hygiene programs, chlorhexidine, CPP-ACP and other interventions.
Dental developmental stage affects the treatment outcome of maxillary protraction in skeletal Class III children: A systematic review and meta-analysis
Authors: Miao Wei , Zhou Dan , Li Chunjie , Chen Lichun , Guan Min , Peng Yiran , Mei Li 
Published: September 2021

Abstract
Background: The aim of this study was to investigate the effect of the stage of dental development on the treatment outcome of maxillary protraction in skeletal Class III children.
Materials and methods: The Medline, Web of Science, Embase, Cochrane Library, CMB and CNKI database were searched to identify all of the relevant articles published prior to 30 August 2019. The grey literature was also searched. Human controlled clinical trials in which patients with a skeletal Class III malocclusion were treated by maxillary protraction (facemask with or without rapid maxillary expansion) were considered. The quality of the included studies was assessed using ROBINS-I. Meta-analysis was performed using RevMan 5.3.
Results: A total of 19 trials were included in the systematic review and 16 trials were included in the meta-analysis, of which three studies were assessed as low risk of bias (high quality), eight were assessed as having a moderate risk of bias, and five were assessed as a high risk of bias. The treatment effect of maxillary protraction in skeletal Class III children was greater in the primary dentition than that in the early mixed dentition with respect to an increase in SNA, ANB and SN/GoGn. The treatment effect was greater in the early mixed dentition than in the late mixed dentition, with an evident decrease in SNB. The treatment effect was greater in the early mixed dentition than that which occurred in the early permanent dentition, with an increase in SNA and ANB. The treatment effect was not significantly different, either between the primary dentition and late mixed dentition, or between the late mixed dentition and early permanent dentition. No study compared the treatment effect between the primary dentition and early permanent dentition.
Conclusion: The dental developmental stage affects the treatment effect of maxillary protraction in skeletal Class III children. The treatment effect at an early dentition stage may be more effective than that at a late dentition stage in improving a skeletal Class III relationship. Although the variations in effectiveness between the various dental stage groups were generally statistically significant, most variations were small, with unclear clinical significance.
The effectiveness of Hawley and vacuum-formed retainer usage protocols on the stability of fixed orthodontic treatment results
Authors: Gorucu-Coskuner Hande , Atik Ezgi , Taner Tülin 
Published: September 2021

Abstract
Objectives: To compare the effectiveness of Hawley and vacuum-formed retainer (VFR) usage protocols on post-treatment stability.
Methods: The inclusion criteria included patients who initially presented with mild or moderate pretreatment crowding and a Class I or Class II malocclusion. The retention protocols were defined as Group 1: Hawley retainers, 12 months full-time wear; Group 2: Hawley retainers, six months full-time, six months night-only wear; Group 3: VFR, 12 months full-time wear; Group 4: VFR, six months full-time, six months night-only wear. Study models were taken prior to treatment (T0), after debonding (T1), six months after debonding (T2), and 12 months after debonding (T3). Little’s irregularity index, intercanine and intermolar widths, arch length, overjet and overbite were measured. Repeated measure ANOVA with one-fixed factor, one-way ANOVA, Kruskal Wallis or Welch’s heteroscedastic F-test, were applied.
Results: Fifty-eight patients were analysed at T2, and 52 patients at T3. There was no significant difference between the effectiveness of a Hawley appliance or VFRs on arch stability after six months. The intercanine width changes from the sixth to 12th month of retention showed a significant difference (p = 0.016) between Group 2 (-0.38 ± 0.58 mm) and Group 3 (0.39 ± 0.94 mm).
Conclusions: Different wearing regimens of a Hawley appliance or VFR retainers did not reveal any difference determined by Little’s irregularity index. Full-time usage of VFRs provided better intercanine width retention than night-only Hawley retainer wear in the maxillary arch.
Tools for improving the efficiency of corporate governance at enterprises of rocket and space engineering
Authors: Абрашкин М.С. , Хорошавина Н.С. , Гусаков М.С. 
Published: September 2021

Сложившиеся условия развития предприятий ракетно-космического машиностроения требуют переосмысления эффективности их корпоративного управления, подходов к формированию советов директоров и обоснованию привлечения независимых директоров в их составах. Специфика отрасли требует трансформации функции целеполагания, усиления роли экономических результатов над общественными, которые при условии превалирования участия государства в акционерных капиталах выступают доминирующими. По результатам исследования 62 предприятий отрасли удалось установить изменение их организационно-правовых форм в сторону нарастания акционерных обществ, а анализ выборочной совокупности из них позволил установить закономерности в корпоративном управлении и концептуализировать предложения по его совершенствованию.
The current conditions for the development of rocket and space engineering enterprises require a rethinking of the effectiveness of their corporate governance, approaches to the formation of Boards of Directors and the rationale for attracting independent directors in their composition. The specifics of the industry require the transformation of the goal-setting function, the strengthening of the role of economic results over public ones, which, given the prevalence of state participation in equity capital, are dominant. According to the results of the study of 62 enterprises in the industry, it was possible to establish a change in their organizational and legal forms towards the growth of joint-stock companies, and the analysis of a sample of them made it possible to establish patterns in corporate governance and conceptualize proposals for its improvement.
Accounting for changes in the norms of expenditure of material resources in the flow of value creation by an industrial enterprise
Authors: Мизиковский И.Е. 
Published: September 2021

Учет изменения норм материальных ресурсов представляет собой сложную и актуальную проблему, обусловленную систематическим увеличением их частоты и направленности. Актуализируется запрос менеджмента на систематизированное представление данных об этих изменениях, адекватно отражаемых в информационном пространстве менеджмента хозяйствующего субъекта промышленной сферы. В статье предложено усовершенствованная методика структурирования и ведения учетных регистров нормированных материальных ресурсов и их отражения с учетом изменений в процессе формирования себестоимости продукции (услуг, товаров) по нормам.
Accounting for changes in the norms of material resources is a complex and urgent problem due to the systematic increase in their frequency and direction. The management's request for a systematic presentation of data on these changes, which is adequately reflected in the management information space of an economic entity in the industrial sphere, is updated. The article offers an improved method of structuring and maintaining accounting registers of standardized material resources and their reflection, taking into account changes in the process of forming the cost of products (services, goods) according to the standards.
Russia's participation in processes of higher education regionalization
Authors: Алексахина В.Г. , Игнатова О.В. 
Published: September 2021

В статье рассматриваются процессы регионализации сферы высшего образования. Региональные союзы обладают существенными преимуществами в экономике и могут успешно конкурировать и на международном рынке при поддержке со стороны правительства. Авторы анализируют факторы, приведшие к активизации интеграционных процессов, а также особенности формирования образовательных консорциумов с участием Российской Федерации, а именно Славянских университетов на постсоветском пространстве, а также Сетевых университетов в рамках СНГ, ШОС и ЕАЭС.
The article deals with the regionalization processes in the sphere of higher education. Regional unions have significant economic advantages and can successfully compete in the international market with government support. The authors analyze the factors that have led to the activation of integration processes and the formation peculiarities of educational consortia with the participation of the Russian Federation. The most famous regional universities are Slavic Universities and Network universities of the CIS, the SCO and the EAEU.
Regional problems of transport and logistics system development in the Russian Federation
Authors: Федотов А.В. , Околелых А.А. 
Published: September 2021

В статье рассматриваются проблемы функционирования транспортно-логистической системы в регионах Российской Федерации. Одной из важнейших задач, стоящих перед федеральными и региональными властями является развитие транспортно-логистической системы регионов. Возникает ряд сложных проблем, таких как: транснационализация товарных рынков из-за углубления кооперации и специализации производства, увеличение количества позиций товарной номенклатуры. Учитывается параллельный рост потребляемой массы продукции, внедрение инновационных технологий в логистические цепочки поставок и другие возникающие изменения.
The article deals with the problems of functioning of the transport and logistics system in the regions of the Russian Federation. One of the most important tasks facing the federal and regional authorities is the development of the transport and logistics system of the regions. There are a number of complex problems, such as: the transnationalization of commodity markets due to the deepening of cooperation and specialization of production, an increase in the number of items in the commodity nomenclature. It takes into account the parallel growth of the consumed mass of products, the introduction of innovative technologies in the logistics supply chain and other emerging changes.
Impact of the COVID-19 pandemic on the food industry
Authors: Бурденко Е.В. , Кадиева А.Т. 
Published: September 2021

Проводится анализ и изучение степени влияния введенных карантинных мер из-за начала и вспышки коронавирусной инфекции на отрасль общественного питания в России и других странах. В статье приведены статистические данные о текущей ситуации в данной отрасли, а также описаны варианты антикризисных мероприятий для предотвращения дальнейшего ухудшения положения предприятий ресторанного бизнеса.
The analysis and study of the impact of the introduced quarantine measures due to the onset and outbreak of coronavirus infection on the catering industry in Russia and other countries is being carried out. The article provides statistical data on the current situation in this industry, as well as describes options for anti-crisis measures to prevent further deterioration of the restaurant business.
Chronological aspects of the implementation of industrial management information systems at the macro level
Authors: Веселовский М.Я. , Сидоров М.А. 
Published: September 2021

Исторический анализ цифровизации в сфере государственного управления показывает, что использование в осуществляющемся на макроуровне регулировании экономических процессов возможно широкое применение информационных систем. Данная статья посвящена изучению информационных систем управления промышленностью на макроуровне как в историческом отношении, так и существующих. В ходе исследования выполнен анализ советских информационных систем, концепции их внедрения и развития, а также системы, функционирующей в рамках рыночной экономики. Выдвинут ряд прогнозных предположений о перспективах развития данных систем.
The historical analysis of digitalization in the field of public administration shows that the use of information systems in the regulation of economic processes carried out at the macrolevel is possible. This article is devoted to the study of information systems for industrial management at the macro level. In the course of the study, the analysis of Soviet information systems, the concept of their implementation and development, as well as the system functioning within the framework of the market economy was carried out. A number of predictive assumptions have been made about the prospects for the development of these systems.
Risk assessment of additional financial costs on the example of implementation of projects of the rocket space industry
Authors: Докукина Е.В. , Парфенова Е.В. 
Published: September 2021

В работе исследуется один из возможных метод оценки риска дополнительных финансовых незапланированных затрат в рамках реализации проектов ракетно-космической отрасли, поскольку по различным причинам они не учитывались при определении технико-экономических показателей реализуемого перспективного проекта. Следовательно, предлагаемый метод позволяет на ранних стадиях проведения исследований оценить дополнительные затраты и учесть их влияние на конечные технико-экономические показатели перспективного проекта. Метод строится на основе статистического анализа затрат по этапам жизненного цикла и по проекту в целом. По итогам исследования сделан вывод о том, что риск дополнительных финансовых затрат может снизить эффективность проекта в полтора - три раза.
The paper explores one of the possible methods for assessing the risk of additional unplanned costs for the implementation of a promising project. Under additional means costs that for some reason were not planned when determining the technical and economic indicators of the prospective project being implemented. The proposed method allows for the early stages of research to assess the additional costs and take into account their impact on the final technical and economic indicators of a promising project. The method is based on a statistical analysis of costs for the stages of the life cycle and for the project as a whole. The study concluded that the risk of additional costs may reduce the effectiveness of the project in one and a half to three times.
System analysis of the echelon scheme for the formation of the switching field of the centralized video surveillance node of office infocommunication systems
Authors: Семенов А.Б. , Гончаров Д.А. , Лёвкин А.В. 
Published: September 2021

Введено понятие эшелонной схемы построения коммутационного поля центрального узла систем IP-видеонаблюдения и выполнена соответствующая ей модернизация типовых принципов расположение образующего его оборудования. Обоснована возможность размещения оборудования центрального узла в 19-дюймовом шкафу шириной 600 мм при количестве телекамер вплоть до 480. Проведена оценка средней длины коммутационных шнуров и показано, что обращение к эшелонной схеме дает практически двукратное сокращение этого параметра, что улучшает условия администрирование системы.
The concept of an echelon scheme for constructing the switching field of the central node of IP-video surveillance systems was introduced and the corresponding modernization of the standard principles of the arrangement of the equipment forming it was performed. The possibility of placing the equipment of the central unit in a 19-inch cabinet 600 mm wide with the number of cameras up to 480 was substantiated. The estimation of the average length of the patch cords was carried out and was shown that the use of the echelon scheme gave an almost double reduction of this parameter that improved the conditions for system administration.
Formation of an expanded criteria base for managing the effectiveness of the most important elements of advanced space systems for monitoring the Earth's gravitational field
Authors: Азаренко Л.Г. 
Published: September 2021

В статье рассматриваются подходы к формированию критериальной базы оценки эффективности при проектировании перспективных космических систем на примере космических систем мониторинга гравитационного поля Земли. Сформулированы основные требования к созданию критериальной базы. Дано определение критерия и обобщенного критерия эффективности применительно к элементам перспективных космических систем. Рассмотрены общие и частные критерии эффективности перспективных космических систем в зависимости от назначения конкретной системы (оборонного применения, гражданские, многоцелевые).
The article considers approaches to the formation of a criteria base for evaluating the effectiveness of the design of advanced space systems on the example of space systems for monitoring the Earth's gravitational field. The main requirements for creating a criteria base are formulated. The definition of the criterion and the generalized criterion of efficiency in relation to the elements of advanced space systems is given. General and specific criteria for the effectiveness of advanced space systems are considered, depending on the purpose of a particular system (defense, civil, multi-purpose).
Designing of a combined propulsion system for the first stage of the rocket
Authors: Щурин К.В. , Береснев С.А. , Капустин В.А. 
Published: September 2021

Статья посвящена разработке комбинированной двигательной установки первой ступени ракеты. Рассмотрены действующие системы, их преимущества и недостатки, а также задача выведения большего количества полезной нагрузки в космос за счёт уменьшения веса топлива, а также улучшения экологического фактора. Показана аналогичная разработка КДУ. Представлены расчеты веса конструкции и количества топлива.
The article is devoted to the development of the combined propulsion system of the first stage of the rocket. The current systems, their advantages and disadvantages, as well as the task of bringing more payload into space by reducing the weight of fuel, as well as improving the environmental factor are considered. A similar development of the CPS is shown. Calculations of the weight of the structure and the amount of fuel are presented.
The Roles of Signaling Pathways in Cardiac Regeneration
Authors: Valizadeh Amir , Asghari Samira , Mansouri Parinaz , Alemi Forough , Majidinia Maryam , Mahmoodpoor Ata , Yousefi Bahman 
Published: September 2021

Abstract:In recent years, knowledge of cardiac regeneration mechanisms has dramatically expanded. Regeneration can replace lost parts of organs, common among animal species. The heart is commonly considered an organ with terminal development, which has no reparability potential during post-natal life. However, some intrinsic regeneration capacity has been reported for cardiac muscle, which opens novel avenues in cardiovascular disease treatment. Different endogenous mechanisms have been studied for cardiac repairing and regeneration in recent decades. Survival, proliferation, inflammation, angiogenesis, cell-cell communication, cardiomyogenesis, and anti-aging pathways are the most important mechanisms that have been studied in this regard. Several in vitro and animal model studies focused on proliferation induction for cardiac regeneration reported promising results. These studies have mainly focused on promoting proliferation signaling pathways and demonstrated various signaling pathways such as Wnt, PI3K/Akt, IGF- 1, TGF-β, Hippo, and VEGF signaling cardiac regeneration. Therefore, in this review, we intend to discuss the connection between different critical signaling pathways in cardiac repair and regeneration.
Entrectinib: A New Selective Tyrosine Kinase Inhibitor Approved for the Treatment of Pediatric and Adult Patients with NTRK Fusionpositive, Recurrent or Advanced Solid Tumors
Authors: Osman Hind M. , Tuncbilek Meral 
Published: September 2021

Background:Entrectinib is a highly potent ATP-competitive and selective inhibitor of tyrosine kinases - Trk A B C, ALK, and ROS1. It was developed by Roche and initially approved in Japan in 2019 to treat pediatric and adult patients with NTRK fusionpositive, recurrent, or advanced solid tumors. In August 2019, entrectinib received accelerated approval by the U.S FDA for this indication. It is also the first FDA-approved drug designed to target both NTRK and ROS1.Objective:We aim to summarize recent studies related to the synthesis, mechanism of action, and clinical trials of the newly approved selective tyrosine kinase inhibitor entrectinib.Method:We conduct a literature review of the research studies on the new highly-potent small-molecule entrectinib.Conclusion:Entrectinib, based on three clinical studies (ALKA, STARTRK-1, and STARTRK-2), was well tolerated, with a manageable safety profile. It induced clinically meaningful responses in recurrent or advanced solid tumors associated with NTRK fusion- positive or ROS1+ NSCLC. It demonstrated substantial efficacy in patients with CNS metastases.
Protective Effects of Curcumin against Iron-induced Toxicity
Authors: Moinipour Nastaran , Barati Mahdi , Sahebkar Amirhossein , Iranshahy Milad , Shakeri Abolfazl 
Published: September 2021

:
Iron is an essential element in cellular metabolism that participates in many biochemical reactions. Nevertheless, iron overload in the body is the cause of damage in some organs including the liver, glands, brain, heart, gastrointestinal tract and lung. Iron chelation therapy could be con-sidered an effective approach for removing excess iron. Deferoxamine, deferiprone and deferasirox are three common iron chelators in clinical practice but cause several side effects. In this context, the use of curcumin, a dietary phytochemical derived from turmeric, as a natural and safe antioxi-dant with iron-chelating activity may be a useful strategy for the management of iron overload. This review focuses on the deleterious effect of iron accumulation in different organs of the body as well as the therapeutic potential of curcumin against iron-induced toxicity.