bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical characteristics and long-term outcomes following surgery combined with adjuvant radiotherapy for patients with frontal sinus malignancies
Authors: Wang Zekun , Zhang Jianghu , Wu Runye , Zhang Ye , Yi Junlin , Gao Li , Xu Guozhen , Luo Jingwei 
Published: May 2021

Abstract
Objective: This study aimed to determine clinicopathologic characteristics of primary frontal sinus malignancies (FSMs) and provide long-term survival results.Materials and methods: A retrospective study of six cases of primary FSMs at our center from 2006 to 2016 was performed. The demographics characteristics, tumor characteristics, treatment modalities and survival outcomes were recorded. Results: In this series, the median age was 48 years (30-53 years) and all patients were male. There were five cases with squamous cell carcinoma, and one with osteosarcoma. All cases presented with locally advanced disease without regional lymphatic metastasis, including 5 cases of stage Ⅲ and one of stage Ⅱ. The two most common pathways of tumor invasion were as follows: local tumor broke posteriorly through bone wall and invaded dura mater, followed by frontal lobe; local tumor infiltrated downward through the floor of frontal sinus into ethmoid sinus, thereafter invaded laterally orbit and orbital contents. All patients received surgery followed by postoperative radiotherapy at the total doses of 50Gy to 75.95Gy. Among them, only one patient underwent R0 resection, the rest of patients underwent R1/R2 resection. With a median survival time of 56 months (32 to 76 months), two patients receiving R1/R2 resection developed treatment failure and died within 5 years, including one case with local recurrence, and one with local recurrence thereafter distant metastasis. Conclusion: The majority of FSMs presented with peripherally invasive progression lesions, which led to a high ratio of R1/R2 resection. Surgery combined with postoperative radiotherapy might result in satisfactory efficacy.
Effect of Long-term Adjuvant Temozolomide Chemotherapy on Primary Glioblastoma Patient Survival
Authors: Huang Bin , Yu Zuan , Liang Risheng 
Published: May 2021

Abstract
Objective: Glioblastoma multiforme (GBM) is the most common primary malignant central nervous system (CNS) tumor. The Stupp regimen is the standard treatment , although the optimal number of temozolomide (TMZ) treatment cycles remains controversial. We compared the effects of standard 6 cycles versus >6 cycles of TMZ chemotherapy post-surgery with concurrent chemoradiotherapy on primary GBM patient survival. Patients and Methods: We performed a single center retrospective study of GBM patients that underwent total resection, concurrent chemoradiotherapy, and at least 6 cycles of adjuvant TMZ chemotherapy from June 2011 to August 2018. Patients were divided into 2 groups based on adjuvant TMZ treatment plan: Group A（n=27）: standard 6-cycle adjuvant TMZ therapy and Group B(n=26): >6 cycles of adjuvant TMZ therapy. Primary endpoints were progression-free survival (PFS) and overall survival (OS). Continuous variables were analyzed by ANOVA, and the Kaplan-Meier method was used to evaluate PFS and OS. Univariate and multivariate COX analyses determined correlation between survival rates and covariates.Results: After follow-up, median PFS was 15 months in in Group A (95%CI 9.5-20.5) and 20.1 months in Group B (95%CI 15.9-24.4). Group A median OS was 19.4 months (95%CI 15.5-23.2), compared to 25.6 months in Group B (95%CI 20.4-30.8). The 2-year survival rate of Groups A and B was 36% was 66%, respectively (P=0.02). and 5-year survival was 7% in both. Multivariate COX regression analysis showed association between patient PFS and long-period adjuvant chemotherapy, but not OS. Conclusions: Long-term adjuvant TMZ chemotherapy benefits PFS and 2-year survival rate but not OS. We do not suggest prolonging TMZ maintenance therapy beyond six cycles in patients with glioblastoma after total resection.
Theoretical Study on Pentiptycene Molecular Brake: Photoinduced Isomerization and Photoinduced Electron Transfer
Authors: Wang Hailong , Guan Qiuping , Wang Xueye 
Published: May 2021

Abstract
The isomerization of the double bond plays an important role in the braking and de-braking of the light-driven molecular brake. Therefore, the Pp-type light-controlled molecular brake system containing the C=C double bond was theoretically studied. Combining the 6-31G(d) basis set, the ωB97XD functional with dispersion correction was applied to implement the (E)-configuration and (Z)-configuration initial optimization. Next, using the 6-311G(d,p) basis set, the relaxed potential energy surface scans of the rotation angle were operated, and then the optimization calculations of the transition states at the extremum high points. Analyzing the stagnation points and the rotational transition state on the MEPs, the rotation mechanism and basic energy parameters of the molecular brake were obtained. Then the DFT computations at ground states and the TD-DFT computations of vertical excitation energy was put into practice at the accuracy of the def-TZVP basis set for the two configurations, and using the natural transition orbital (NTOs) analyses combining the excitation energies and absorption spectrums of the molecules, the electronic transition characteristics and electron transfer properties of light-driven molecular brake were studied. Afterwards, in order to investigate the photo-induced isomerization reaction, the C=C double bond was scanned on the relaxed potential energy surface, and the intermediates of the isomerization reaction was searched and analyzed, thus, the braking mechanism of the light-driven molecular brake was proposed.
Recanalization After False Lumen Stent Placement During Iatrogenic Coronary Dissection: A Case Report.
Authors: Li Jing , Dong Liang 
Published: May 2021

Abstract
Iatrogenic coronary artery dissection is an uncommon but life-threatening complication of coronary angiography and angioplasty. It may result in devastating consequences if not promptly treated with immediate revascularization. We report a case of recanalization after false lumen stent placement during iatrogenic coronary dissection.
Online Pregnancy-Related Information: Reliability and Worries Among Expectant Women In Qatar
Authors: Al-Dahshan Ayman , Chehab Mohamad , Selim Nagah 
Published: May 2021

Abstract
Background: Although the internet can be a source of reassurance and clarification for expectant women, it ‎could cause concerns or feelings of worry when reading about pregnancy-related ‎information. The current research sought to assess the feelings of worry and perceived reliability towards online pregnancy-related information and the associated factors among expectant women attending antenatal clinics at primary healthcare centers in Qatar.Methods: A cross-sectional study design was employed. The participants were recruited through a systematic random sampling technique. ‎A self-administered questionnaire was used to collect data from the participants. Descriptive and analytic statistics were used when appropriate‎.Results: A total of 327 expecting women completed the questionnaire. Most participants were aged between 26-34 years (74.1%), held a college/university degree (76.4%), and multigravidas (73.1%). About one-third of the women ‎(31.2‎%) reported feeling worried due to something they read online. The participants coped with these feelings by consulting their antenatal care provider at the next appointment (51.0%) or by talking with relatives and friends (47.0%). Furthermore, most women (79.2%) considered online pregnancy-related information to be reliable or highly reliable. Holding a college/university degree, primigravidae, and having no children were factors significantly associated with a high perception of reliability of online health information.Conclusion: Although online pregnancy information caused feelings of worry for some pregnant ‎women, most women perceived such information to be reliable. Thus, antenatal care providers should be equipped to guide pregnant women on how to access high-quality web-based information.
Information and Communication Technologies (ICTs) Enabling Integrated Primary Care for Complex Patients: A Protocol for a Scoping Review
Authors: Tahsin Farah , Armas Alana , Kirakalaprathapan Apery , Cunningham Heather , Kadu Mudathira , Sritha Jasvinei , Gray Carolyn Steele 
Published: May 2021

Abstract
IntroductionAn increasing number of individuals are living with multiple chronic conditions, often combined with psychosocial complexities. For these patients with complex conditions, an integrated primary care model that provides care coordination and a team-based approach can help manage their multiple needs. Information and communication technologies (ICTs) are recognized as a critical enabler of integrated primary care. A better understanding of the use of ICTs in an integrated care setting and how ICTs are being leveraged would be beneficial to identify knowledge gaps and could lead to successful implementation for ICT-based interventions.ObjectiveThis study will systematically scope the literature on the topic of ICT-enabled integrated healthcare delivery models for patients with complex care needs to identify which technologies have been used in integrated primary care settings. MethodThis study protocol outlines a scoping review of the peer-reviewed literature, using Arksey and O’Malley’s (enhanced by Levac et al.) scoping review methodology. Peer-reviewed- literature will be identified using a multi-database search strategy. The results of the search will be screened, abstracted, and charted in duplicate by 6 research team members. Discussion﻿The key findings of the study will be thematically mapped to describe the implemented ICTs aimed for complex patients within the integrated primary care model and interactions of the elements (ICT, health model, and targeted patients). This review will be the first step to formally identify how ICT is used to support integrated primary health care models. The results will be disseminated through peer-reviewed publications, conference presentations, and special interest groups.
A Jigsaw Puzzle based Reconfiguration Technique for Enhancing Maximum Power in Partial Shaded Hybrid Photovoltaic Array
Authors: M Palpandian , David Prince Winston , Elavarasan Rajvikram Madurai , Periyasamy Pounraj , Pugazhendhi Rishi , Shafiullah GM , Natarajan Sendhil Kumar 
Published: May 2021

Abstract
The authors have requested that this preprint be removed from Research Square.
The Transfer Function of the SARS-CoV-2 Spread in Different Countries with Stability, Observability, and Controllability Analysis
Authors: Šajić Jasmina Lozanović , Langthaler Sonja , Stoppacher Sara , Baumgartner Christian 
Published: May 2021

Abstract
This paper presents the determination of the transfer function of the spreading pandemic caused by SARS-CoV-2 in different countries. The methodology of system identification, well known in control system theory, based on the number of infected was used. Appropriate hypotheses have been adopted to determine the transfer function of the system. Each country is viewed as a separate system, and comparisons of determined systems are given. The systems are also presented in the state space, the stability of the systems is analysed, and the matrices of controllability and observability are determined. After analysis, it is shown that the spread of the SARS-CoV-2, for each country, can be described with the same order of transfer function and differential equation.
How Spatial Attention Affects the Decision Process: Looking through the Lens of Bayesian Hierarchical Diffusion Model &amp; EEG Analysis
Authors: Ghaderi-Kangavari Amin , Rad Jamal Amani , Parand Kourosh , Ebrahimpour Reza 
Published: May 2021

Abstract
Model-based cognitive neuroscience consolidates the cognitive processes and neurophysiological oscillations which are reflections of behavioral performance (e.g., reaction times and accuracy). Here, based on one of well-known sequential sampling models (SSMs), named the diffusion decision model, and the nested model comparison, we explore the underlying latent process of spatial prioritization in perceptual decision processes, so that for estimating the model parameters (i.e. the drift rate, the boundary separation, and the non-decision time), a Bayesian hierarchical approach is considered, which allows inferences to be done simultaneously in the group and individual level. Moreover, well-established neural components of spatial attention which contributed to the latent process and behavioral performance in a visual face-car perceptual decision are detected based on the event-related potential (ERP) analysis. Our cognitive modeling analysis revealed that the non-decision time parameter provides a better fit to the top-down attention with the measures of two powerful weapons, i.e. the deviance information criterion called DIC score and R-square. Also, using multiple regression analysis on the contralateral minus neutral N2 sub-component (N2nc) at central electrodes and contralateral minus neutral alpha power (Anc) at posterior-occipital electrodes in the voluntary attention, it can be concluded that poststimulus N2nc can predict reaction time (RT) and non-decision time parameter relating to spatial prioritization. Whereas, the poststimulus Anc only can predict the RT and not the non-decision time relating to spatial prioritization. The result suggested that the difference of contralateral minus neutral oscillations was more important to reflect the modulation of the top-down spatial attention mechanism in comparison with the difference of ipsilateral minus neutral oscillations.
Two-Photon–NIR-II Antimicrobial Graphene-Nanoagent for Ultraviolet–NIR Imaging and Photoinactivation
Authors: KUO WEN-SHUO , Chang Chia-Yuan , Wu Ping-Ching , Wang Jiu-Yao 
Published: May 2021

Abstract
BackgroundNitrogen doping and amino-group functionalization, which result in strong electron donation, can be achieved through chemical modification. Large π-conjugated systems of graphene quantum dot (GQD)-based materials acting as electron donors can be chemically manipulated with low two-photon excitation energy in a short photoexcitation time for improving the charge transfer efficiency of sorted nitrogen-doped amino acid–functionalized GQDs (sorted amino-N-GQDs). ResultsIn this study, a self-developed femtosecond Ti-sapphire laser optical system (222.7 nJ pixel−1 with 100-170 scans, approximately 0.65-1.11 s of total effective exposure times; excitation wavelength: 960 nm in the near-infrared II region) was used for chemical modification. The sorted amino-N-GQDs exhibited enhanced two-photon absorption, post-two-photon excitation stability, two-photon excitation cross-section, and two-photon luminescence through the radiative pathway. The lifetime and quantum yield of the sorted amino-N-GQDs decreased and increased, respectively. Furthermore, the sorted amino-N-GQDs exhibited excitation-wavelength-independent photoluminescence in the near-infrared region and generated reactive oxygen species after two-photon excitation. An increase in the size of the sorted amino-N-GQDs boosted photochemical and electrochemical efficacy and resulted in high photoluminescence quantum yield and highly efficient two-photon photodynamic therapy. Conclusion﻿The sorted dots can be used in two-photon contrast probes for tracking and localizing analytes during two-photon imaging in a biological environment and for conducting two-photon photodynamic therapy for eliminating infectious microbes.
miR-20a-5p/RBM24 Axis Alleviated Hypertensive Intracerebral Hemorrhage via Regulating HIF1α/VEGFA Signaling Pathway
Authors: Xu Li , Mo Chuangqi , Lu Ming , Wang Pingping , Liu Yue 
Published: May 2021

Abstract
Background: Hypertensive intracerebral hemorrhage presented high incidence and high mortality owing to its difficult to diagnose. However, the molecular mechanism of HICH remains unclear. Therefore, this study aims to investigate the key miRNAs and the mechanism of the key miRNAs in HICH. Methods: miRNAs chip was used to explore the differentially expressed miRNAs in HICH patients. In vitro and in vivo HICH models were established by Ang-II. Cell Counting Kit-8 (CCK8), flow cytometry, transwell assay and tube formation analysis were used to detect cell proliferation, apoptosis, cell migration and tube formation, respectively. Hematoxylin-eosin staining was used to evaluate the intracerebral hemorrhage in vivo HICH model. The regulatory mechanism of miR-20a-5p in HICH was confirmed by dual luciferase reporter assay, immunofluorescence, qRT-PCR, western blot and rescue experiments. Results: miR-20a-5p showed the most downregulated in HICH patients compared with healthy individuals and significantly associated with clinicopathological characteristics of HICH. Upregulation of miR-20a-5p promoted cell proliferation, migration and tube formation while inhibited apoptosis in vitro and ameliorated the development of HICH in vivo. RBM24 is a direct target of miR-20a-5p and silencing RBM24 could partially recovery the development of HICH caused by miR-20a-5p inhibition both in vivo and in vitro. miR-20a-5p regulated the development of HICH depending on HIF1α/VEGFA pathway. Conclusion: Our results demonstrated that miR-20a-5p/RBM24 axis regulated hypertensive intracerebral hemorrhage via regulating HIF1α/VEGFA signaling pathway, in support of further investigation into miR-20a-5p therapies for HICH treatment.
Classic Ciliated Muconodular Papillary Tumor of the Lung With Braf Mutation: The New We Should Know
Authors: Zhang Minfen , Zhao Li , Liu Shaoyan , Tan Xuexian , Jiang Qingping , Wang Na 
Published: May 2021

Abstract
Background Ciliated muconodular papillary tumor (CMPT) was initially recognized as three typical types of cells (ciliated cells, mucinous cells and basal cells) and two typical structures (papillary and tubular). It is found that the proportion of various cells is different and papillary structure is not necessary. So some scholars propose that CMPT is a proximal-type bronchiolar adenoma (BA) which expands the concept of CMPT. At the same time they propose revising the terminology. These morphological variations bring great challenges to the diagnosis. Case presentation: Multiple small nodules in bilateral lungs were found in 79-year old female patient. A frozen examination was performed. Grossly, there were jelly-like nodules with clear boundaries, and the maximum diameter was about 4mm. Microscopically, glandular ducts, papillary and even micropapillary structures were seen. The cavities were lined by columnar cell and mucous cells. In a low-power field the conspicuous mucin pool was observed, as well as floating tumor cells in the mucin pool. So atypical adenomatous hyperplasia of the lung was reported in intraoperative rapid diagnosis, and the surgeon performed a lobectomy for the patient. In typical HE, this tumor was made up of three kinds of cells in different proportions, including ciliated columnar cells, mucous cells, and basal cells which were confirmed by CK5/6 and P63 immunohistochemistry staining. Immunohistochemical analysis reveals thyroid transcription factor1 (TTF-1) and CK7 expression by ciliated columnar epithelial cells, basal cells, and nonciliated columnar and cuboidal epithelial cells, but not mucous cells. All the cells do not express CK20. BRAF V600E protein express in the tumor. At the same time, the tumor harbores the BRAF gene mutation, while EGFR, KRAS, ALK, HER-2, RET, ROS-1, PIK3CA and NRAS mutation are negative.Conclusion We report a classic CMPT. The tumor has BRAF mutation and BRAF protein expression. Classic lesions are easy to identify, while for morphological variant cases, the key to the diagnosis of the disease is the diversity of cell components and the presence of basal cells.
Geriatric Care Competencies for Undergraduate Medical Curriculum: a Scoping Review Protocol
Authors: Nojomi Marzieh , Goharinezhad Salime , Delavari Somayeh , Aletaha Azadeh 
Published: May 2021

Abstract
Background: Rapid demographic change and aging population demand that health professional’s especially general physicians need to be better competent around older adults' care and managing multiple conditions of them. Evidence shows that the current gap in health care professionals’ skills and the lack of medical school training for caring well the aging population. Therefore, health professions need to improve geriatric competencies in the curriculum to care for and met older adult’s preferences.Objective: The objective of this scoping review is to identify core competencies relevant to geriatric care in the undergraduate medical curriculum.Methods: This scoping review protocol is based on the Arksey and O’Malley framework and further developed by Levac et al. Four databases including PubMed, ERIC, Scopus, and Web of Science will be searched. Citation searching for identifying additional studies, through reference lists checking of studies and reviews will be applied. Studies in English and Persian language, published from 01/01/ 2015 to 12/31/2020, will be included. Data will be extracted based on ACGME (Accreditation Council for Graduate Medical Education) Core Competencies Framework. Selected studies will be reviewed and data extracted by two independent reviewers, and presented in table or chart, and synthesized in thematic format.Conclusion: All analyses in this study will be based on the previously published papers. The present scoping review will provide evidence-based information on core competencies for revising the undergraduate medical curriculum related to geriatric care.
Investigation of Nonlinear Creep Behaviour of Millettia Laurentii Wood Through Zener Fractional Rheological model
Authors: Prisca Atchounga Kuida , Michel Njankouo Jacques , Emmanuel Foadieng , Kisito Talla Pierre 
Published: May 2021

Abstract
Nowadays one of the principal difficulties that wood structural development and construction have to face is wood creep. Nevertheless, the secret to master and solve the creep deformation of wood relies on a sensible and exact rheological model for numerical analysis. In this research work our goal is to study the nonlinear creep behaviour of the Cameroonian wood species Millettia Laurentii known as Wengé wood through fractional calculus approach. So, we have conducted a nonlinear creep constitutive model of Millettia Laurentii wood, that is the Zener fractional rheological model, and the parameters of this model have been determined. We have studied the influence of stress level σ and fractional order n on the Millettia Laurentii wood creep process by a sensitivity analysis of the model parameters. The outcomes of this sensitivity analysis are of paramount importance because they can be used in reality to inspect the creep process and deformation amount of Millettia Laurentii wood in practical engineering. Moreover, guidance for the secure construction of Millettia Laurentii wood engineering can be given by the means of the findings of this research.