bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of the Yahoo-yahoo Hash-tag Tweets Using Sentiment Analysis and Opinion Mining Algorithms
Authors: Abayomi-Alli Adebayo , Abayomi-Alli Olusola , Misra Sanjay , Fernandez-Sanz Luis 
Published: April 2021

Abstract
BackgroundSocial media opinion has become a medium to quickly access large, valuable, and rich details of information on any subject matter within a short period. Twitter being a social microblog site, generate over 330 million tweets monthly across different countries. Analyzing trending topics on Twitter presents opportunities to extract meaningful insight into different opinions on various issues.AimThis study aims to gain insights into the trending yahoo-yahoo topic on Twitter using content analysis of selected historical tweets.MethodologyThe widgets and workflow engine in the Orange Data mining toolbox were employed for all the text mining tasks. 5500 tweets were collected from Twitter using the 'yahoo yahoo' hashtag. The corpus was pre-processed using a pre-trained tweet tokenizer, Valence Aware Dictionary for Sentiment Reasoning (VADER) was used for the sentiment and opinion mining, Latent Dirichlet Allocation (LDA) and Latent Semantic Indexing (LSI) was used for topic modeling. In contrast, Multidimensional scaling (MDS) was used to visualize the modeled topics. ResultsResults showed that "yahoo" appeared in the corpus 9555 times, 175 unique tweets were returned after duplicate removal. Contrary to expectation, Spain had the highest number of participants tweeting on the 'yahoo yahoo' topic within the period. The result of Vader sentiment analysis returned 35.85%, 24.53%, 15.09%, and 24.53%, negative, neutral, no-zone, and positive sentiment tweets, respectively. The word yahoo was highly representative of the LDA topics 1, 3, 4, 6, and LSI topic 1.ConclusionIt can be concluded that emojis are even more representative of the sentiments in tweets faster than the textual contents. Also, despite popular belief, a significant number of youths regard cybercrime as a detriment to society.
Fault Compensation Control of MIMO Nonlinear Systems Subject to Unknown Control Directions
Authors: Dun Yi-Fan , Wu Li-Bing , Hu Yu-Han , Fan Jun-Mei , Zhang Zhi-Guo 
Published: April 2021

Abstract
This study is primarily focused on the issue of low-complexity prescribed performance fault compensation for multi-input and multi-output (MIMO) uncertain nonlinear systems with actuator failures, coupling states, and unknown control directions. First of all, proper logarithm-type error conversion functions and smooth orientation functions are linked to design the continuous control signals in the state feedback controller. Then, based on the idea of proof by contradiction, it is shown that the state errors converge to a predictable compact aggregate at the definite rate. Meanwhile, the boundedness of any closed-loop signals might be guaranteed. The simulation example results are delivered to demonstrate the effectiveness of the developed control strategy at last.
A single-nucleotide polymorphism involved in alternative splicing of PTEN is associated with chemotherapy resistance in breast cancer in Chinese population
Authors: Wang Jing , Zhang Shasha , Zhang Zhongliang , Ma Qinglong , Chen Xiaohua , Zhao Dapeng , Zhao Meie , Wang Chunwei , Di Cuixia , xie xiaodong 
Published: April 2021

Abstract
Background

Chemoresistance is still the main reason for the failure of breast cancer treatment and is the main cause of death of breast cancer patients. Although many studies have shown the association between genetic polymorphisms of PTEN and chemotherapy resistance, the molecular mechanism of breast cancer chemotherapy has not been further studied. This study aims to investigate the potential association between PTEN gene polymorphism and breast chemotherapy resistance in the Chinese population, and explore whether alternative splicing of the PTEN gene is affected by the gene polymorphism.
Methods

The study included 234 patients with breast cancer chemotherapy, 157 chemotherapy sensitive cases and 77 chemotherapy resistant cases. rs786204926 of the PTEN gene was analysed by Sanger sequence and Sequenom MassArray typing technology. Furthermore, we used silicon analysis to predict whether polymorphism affect the process of alternative splicing and to analyze how it affects.
Results

In genotyping and allelic analysis, there was a significant association between rs786204926 polymorphism and breast cancer chemotherapy resistance. Carrying the G allele or AG genotype will reduce the risk of breast cancer-based resistance to chemotherapy with anthracyclines. Silicon analysis showed that the mutation of rs786204926 produced a new receptor site, which might affect alternative splicing of PTEN gene.
Conclusions

We speculate that the mechanism of breast cancer chemotherapy resistance might be caused by a change in the alternative splicing caused by the rs786204926 of the PTEN gene. Thus, our study might provide theoretical guidance for the individualized treatment of clinical breast cancer patients.
Multiscale Entropy Analysis of Short Signals: The Robustness of Fuzzy Entropy-Based Variants
Authors: Borin Airton Monte Serrat , Humeau-Heurtier Anne , Murta Luiz Otavio , Silva Luiz Eduardo Virgilio 
Published: April 2021

Abstract
Multiscale entropy (MSE) analysis is a fundamental approach to access the complexity of a time series by estimating its information creation over a range of temporal scales. However, MSE may not be accurate or valid for short time series. This is why previous studies applied different kinds of algorithm derivations to short-term time series. However, no study has systematically analyzed and compared their reliabilities. This study compares the MSE algorithm variations adapted to short time series on both human and rat heart rate variability (HRV) time series. The most used variations of MSE are studied: composite MSE (CMSE), refined composite MSE (RCMSE), modified MSE (MMSE), and their fuzzy versions. We also analyze the errors in MSE estimations for a range of incorporated fuzzy exponents. The results show that fuzzy MSE versions-as a function of time series length-present minimal errors compared to the non-fuzzy algorithms. The traditional multiscale entropy algorithm with fuzzy counting (MFE) has similar accuracy to alternative algorithms with better computing performance. For the best accuracy, the findings suggest different fuzzy exponents according to the time series length.
Cost and consequences of using 7.1% chlorhexidine gel for newborn umbilical cord care in Kenya
Authors: Brown Lecia , Martin Alan , Were Christopher , Biswas Nandita , Liakos Alexander , DeAngelis Elena , Evitt Lee 
Published: April 2021

Abstract
Background: Umbilical-cord infection (omphalitis) is a major cause of neonatal mortality in Kenya. Chlorhexidine 7.1% digluconate gel, (CHX), delivering 4% chlorhexidine was identified as a life-saving commodity for newborn cord care by the United Nations and is included on the World Health Organization and Kenyan Essential Medicines Lists. Methods: We employed a cost-consequence model to assess resource saving and breakeven price of implementing CHX for neonatal umbilical cord care versus dry cord care (DCC) in a Kenyan birth cohort. Firstly, the number of omphalitis cases and cases avoided by healthcare sector were estimated. Economic outcomes associated with omphalitis cases avoided were then determined, including direct, indirect and total cost of care associated with omphalitis, resource use (outpatient visits and bed days) and societal impact (caregiver workdays lost). Treatment effect inputs were calculated from a Cochrane meta-analysis of randomised clinical trials (RCTs) (base case) and 2 other RCTs. Costs and other inputs were sourced from the literature and supplemented by expert clinical opinion/informed inputs, making assumptions as necessary. Reports: The model estimated that, over 1 year, ~23,000 omphalitis cases per 500,000 births could be avoided through CHX application versus DCC, circumventing ~13,000 outpatient visits, ~43,000 bed days and preserving ~114,000 workdays. CHX was associated with annual direct cost savings of ~590,000 US dollars (USD) versus DCC (not including drug-acquisition cost), increasing to ~2.5 million USD after including indirect costs (productivity, notional salary loss). The most-influential model parameter was relative risk of omphalitis with CHX versus DCC. Breakeven analysis identified a budget-neutral price for CHX use of 1.18 USD/course when accounting for direct cost savings only, and of 5.43 USD/course when also including indirect cost savings. The estimated breakeven price was robust to parameter input changes. DCC does not necessarily represent standard of care in Kenya; other, potentially harmful, approaches may be used, meaning cost savings may be understated. Conclusions: Estimated healthcare cost savings and potential health benefits provide compelling evidence to implement CHX for umbilical cord care in Kenya. We encourage comprehensive data collection to make future models and estimates of the impacts of upscaling CHX use more robust.
Reconciling Validity and Challenges of Patient Comfort and Understanding: Guidelines to Patient-Oriented Questionnaires
Authors: Hudon Catherine , Danish Alya , Lambert Mireille , Howse Dana , Cassidy Monique , Dumont-Samson Olivier , Porter Judy , Rubenstein Donna , Sabourin Véronique , Doucet Shelley , Ramsden Vivian R. , Bisson Mathieu , Schwarz Charlotte , Chouinard Maud-Christine 
Published: April 2021

Abstract
Background: Patient-reported outcomes measures (PROMs) are widely recognized as important tools for achieving a patient-centered approach in health research. While PROMs are subject to several stages of validation during development, even questionnaires with robust psychometric properties may pose problems for targeted patients. Challenges can rise for reasons of clarity, understanding, comfort, or the complexity of the patient’s situation (e.g., their health needs). How can good practices in questionnaire development and validation on one hand, and challenges of accommodating patient comfort and understanding on the other hand be reconciled? Building on the experience of patient engagement in the PriCARE research program, this paper aims to propose: 1) steps to address challenges of patient comfort and understanding of the questionnaires and to reach consensus, and 2) patient-oriented guidelines for administrating the questionnaires. Methods: Based on a participatory approach and the patient engagement framework in the Strategy for Patient-Oriented Research of the Canadian Institutes of Health Research, team members, including patient partners, worked together to discuss the problem, review the questionnaires, and come up with different solutions. Based on literature presenting similar processes in research projects, a working group was created to produce guidelines for administering the questionnaires. We present a step-by-step description of strategies used in PriCARE, to reconcile good research practices for using validated questionnaires and the challenges in questionnaire development related to patient comfort and understanding. Results: This paper demonstrates how patient partners were engaged in PriCARE and integrated into the program’s governance structure, the challenges they raised regarding the questionnaires, and how the challenges were addressed in a six-step approach: 1) Recognizing patient partner concerns, discussing these concerns, and reframing the challenges; 2) Detailing and sharing evidence of the validity of the questionnaires; 3) Evaluating potential solutions; 4) Searching literature for guidelines; 5) Creating guidelines; 6) Sharing and refining guidelines. Conclusion: This six-step approach demonstrates how research teams can integrate patient partners as equal members, develop meaningful collaboration through recognition of individual experiences and expertise, and ensure the patient perspective is taken into consideration in questionnaire research, the development of data collection tools, and healthcare innovation in general.
Quality of Life in Patients with Stable Coronary Artery Disease Submitted to Percutaneous, Surgical and Medical Therapies: A Cohort Study
Authors: Silveira Lucas Molinari Veloso da , Almeida Adriana Silveira , Fuchs Felipe C. , Silva Aline Gonçalves , Lucca Marcelo Balbinot , Scopel Samuel , Fuchs Sandra C. , Fuchs Flávio D. 
Published: April 2021

Abstract
Background: Clinical, surgical and percutaneous strategies have been shown similar effectiveness in the prevention of major cardiovascular events in patients with stable coronary artery disease (CAD). The possibility that these strategies have differential effects over health-related quality of life (HRQoL) has been debated, particularly in patients treated outside clinical trials.Methods: 454 patients diagnosed with coronary artery disease during an elective diagnostic coronary angiography were assigned to Coronary Artery Bypass Grafting (CABG), Percutaneous Coronary Intervention (PCI) or optimal medical treatment (OMT), and followed on average for 6.0 ± 1.9 years. HRQoL was assessed by a validated Brazilian version of the 12-Item Short-Form Health Survey (SF-12) questionnaire. The association between therapeutic strategies and scores of QoL were tested by ANOVA and adjusted for confounding in a general linear model. Results: There was no difference in the Mental Component Summary (MCS) scores in the follow-up evaluation by therapeutic strategies: 51.4, 53.7 and 52.3, respectively, for MT, PCI, and CABG. Physical Component Summary (PCS) scores were higher in the PCI group, when compared to the CABG and MT (46.4 vs. 42.9 and 43.8, respectively), but these differences were no longer different after adjustment for confounding variables.Conclusion: In a long-term follow-up of patients with stable CAD, HRQoL was not different in patients treated by medical, percutaneous or surgical treatments.
A novel technique to rebuild the Valsava sinus in acute type A aortic dissection
Authors: Zhao Long , Hong Ruofeng , Fei Jianbin , Li Junpeng , Pan Jianneng , Yang Wenyu 
Published: April 2021

Abstract
Background. There has been many techniques described to preserve the integrity of the aortic root with good outcomes for those with acute type A aortic dissection. However, whether to use these technique in emergency patients presenting with AADA remains controversial.Methods. Between December 2019 and Feburary 2021, 11 patients underwent aortic root partial repair using a button technique.Results. The postoperative echocardiography 1 month after operation showed mild regurgitation in 7 cases and moderate regurgitation in 2 cases. Two patients died because of low cardiac outflow. Temporary neurological dysfunction was observed in one patient and hoarseness occurred in one patient.Conclusions. Our partial aortic root remodeling operation is very easy to operate and has a good short-term effect. It might be a useful strategy for acute type A aortic dissection in patients with one or two Valsalva sinuses affected.
Eukaryotic Initiation Factor-2, Gamma Subunit, Suppresses Proliferation and Regulates the Cell Cycle via the MAPK/ERK&nbsp;Signaling Pathway in Acute Myeloid Leukemia
Authors: Lu Jielun , CHEN SHUYI , TAN HUO , HUANG ZHENQIAN , LI BO , LIU LING , CHEN YIMIN , ZENG XIAOZHEN , ZOU YAWEI , XU LIHUA 
Published: April 2021

Abstract
Purpose The expression of eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) in patients with non-small cell lung and colorectal cancer is lower than that in healthy individuals. However, the functions of EIF2S3 remain unclear, and its study in leukemia has not been reported. The article aims to explore the role of EIF2S3 in AML (acute myeloid leukemia) and its underlying mechanism. Methods Reverse transcription-quantitative PCR was performed to evaluate the expression levels of EIF2S3, and its association with patient prognosis was determined. Inducible HEL-EIF2S3 and HL-60-EIF2S3 cell lines were established by retrovirus infection. Cellular proliferation and the cell cycle were analyzed using Cell Counting Kit 8 and flow cytometric analyses. Tumorigenic ability was evaluated using xenograft nude mouse model. Gene expression profiles were analyzed in HL-60-EIF2S3 cells by next-generation sequencing, and WB analysis was performed to detect the expression of related proteins.Results The expression of EIF2S3 in patients with AML was lower than that experiencing CR (P=0.02). Furthermore, EIF2S3 overexpression inhibited cellular proliferation, halted G0/1 to S phase cell cycle progression and inhibited tumorigenicity (P=0.015). 479 differentially expressed genes were identified between HL60-EIF2S3 DOX (-) and HL60-EIF2S3 DOX (+) cells via NGS and several of them involved in MAPK/ERK signaling pathway. The phosphorylation levels of ERK decreased when EIF2S3 was overexpressed(P＜0.050).Conclusion EIF2S3 overexpression may result in a decrease in cellular proliferation, cell cycle arrest and tumorigenic inhibition via the MAPK/ERK signaling pathway in AML cells.
The Digitally Associated Display Model For Convenience Stores: A Case Study
Authors: Jing Shuwei , Li Mingxia , Zhang Qian , Yang Fudong 
Published: April 2021

Abstract
Commodity display is one of the important means to improve customer shopping experience and enhance competitiveness in the convenience. Previous research only based on the characteristics of the commodities, but did not consider the importance of customers to display of commodities. Therefore, this paper presents the digitally associated display model that combines customer group concepts and digital means to mine customer and commodities information. First, analyze the preliminary association rules of commodities by Apriori algorithms, to provide data support, and check whether the data is true and feasible. Second, apply RFM model to analyze customers to get the importance of customers. Finally, construct a digital display model that combines customer group concepts and digital means to mine customer and commodities information. The research showed that: (1) the digitally associated display model can provide a scientific basis for the community convenience store to optimize the way of commodity display; (2) the digitally associated display model can optimize the layout of commodities to bring great room for profit growth for convenience stores. (3) the digitally associated display model can provide a reference for optimizing customer management methods, which is conducive to enhancing customers' shopping experience and satisfaction.
Identification of a Novel Interaction of FUS and Syntaphilin May Explain Synaptic and Mitochondrial Abnormalities Caused by ALS Mutations
Authors: Vance Caroline , Salam Shaakir , Tacconelli Sara , Smith Bradley N , Mitchell Jacqueline C , Glennon Elizabeth , Nikolaou Nikolas , Houart Corinne 
Published: April 2021

Abstract
BackgroundAberrantly expressed fused in sarcoma (FUS) is a hallmark of FUS-related amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Wildtype FUS localises to synapses and interacts with mitochondrial proteins while mutations have been shown to cause to pathological changes affecting mitochondria, synapses and the neuromuscular junction (NMJ) This indicates a crucial physiological role for FUS in regulating synaptic and mitochondrial function that is currently poorly understood.MethodsNeurite complexity and synaptic density were studied in rat primary neurons expressing eGFP-FUSWT, eGFP-FUSR514G or eGFP-FUSΔNLS. To investigate synaptic and neuronal changes in vivo, a motor neuron specific zebrafish over-expression model with mosaic expression of MNX1:Gal4 and UAS: eGFP-FUSWT, UAS: eGFP-FUSR514G or UAS: eGFP-FUSΔNLS was assessed for alterations to axonal growth, branching and NMJ density. Using live imaging, mitochondrial trafficking in in vitro neuronal models expressing mutant FUS was conducted. Complementary proximity ligation assays assessed endogenous protein interactions, while overexpression of mutant FUS evaluated if mutations led to alterations in this interaction. Lastly, Puromycin assays investigated how mutant FUS caused differences in global protein translation. ResultsWe found that mutant FUS alters synaptic numbers and neuronal complexity in both primary neurons and zebrafish models. The degree to which FUS is mislocalised leads to differences in the synaptic changes which is mirrored by changes in mitochondrial numbers and transport. Furthermore, we showed that FUS interacts and localises with Syntaphilin (SNPH), and that mutations in FUS affect this relationship, which may lead to the synaptic and mitochondrial phenotypes observed. Finally, we demonstrated that in primary neurons mutant FUS-driven changes in global protein translation correlate with synaptic and mitochondrial defects shown for each respective mutation. ConclusionsWe provide evidence that mislocalised cytoplasmic FUS causes mitochondrial and synaptic changes and that FUS plays a vital role in maintaining neuronal health in vitro and in vivo. Moreover, we demonstrate a novel interaction between FUS and SNPH, which could explain the synaptic and mitochondrial defects observed leading to global protein translation defects. Importantly, our results support the ‘gain-of-function’ hypothesis for disease pathogenesis in FUS-related ALS.
Impact of Reconstruction Parameters on Spatial Resolution and Its Comparison Between Cadmium-Zinc-Telluride&nbsp;SPECT/CT and Conventional SPECT/CT
Authors: Wang Miao , Dong Sheng , Zhang Ruyi , Wang Shen , Shen Yiming , Li Ning , Wang Peng , Tan Jian , Meng Zhaowei , Jia Qiang 
Published: April 2021

Abstract
Background: To evaluate the impact of reconstruction parameters on spatial resolution of tomographic image in SPECT/CT, and to compare spatial resolution between a new polyvalent whole-body Cadmium-Zinc-Telluride camera (CZT-SPECT/CT) and a conventional dual-head Anger camera (conventional SPECT/CT). Spatial resolution was evaluated with four line sources filled with 99mTc in tomographic images reconstructed by varying reconstruction parameters. Ordered-subset expectation maximization (OSEM) algorithm was performed with varying iterations (1-20), the number of subsets was fixed at 10. Butterworth filter, Gauss filter and no-filter were selected respectively. Computed tomography-based attenuation correction (CTAC), scatter correction (SC), resolution recovery (RR) and no-correction (NC) were adopted for image correction respectively. Filtered back projection (FBP) with Butterworth filter and CTAC was also performed in image reconstruction. Spatial resolution was expressed by full width at half-maximum (FWHM) value.Results: The impact of reconstruction parameters on spatial resolution was identical in both cameras: FWHM values decreased with the increase of iterations and converged uniformly when the number of iterations was over 4. FWHM values decreased with the increase of cutoff frequency of Butterworth filter and increased with the increase of Gauss filter. SC and RR improved spatial resolution, whereas CTAC had negligible effect on spatial resolution reconstructed by OSEM. FWHM was generally lower with OSEM reconstruction than FBP reconstruction. On the whole, under the same reconstruction conditions, CZT-SPECT/CT had a lower FWHM value than conventional SPECT/CT.Conclusions: The spatial resolution was improved with the increase of iterations. Increasing the cutoff frequency of Butterworth filter and decreasing the Gauss filter enhanced spatial resolution. The spatial resolution was better reconstructed by OSEM associated with AC, SC and RR than FBP. CZT-SPECT/CT had better spatial resolution than conventional SPECT/CT.