bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benefit Points for the Portfolio
Authors: Hannay Jo Erskine 
Published: June 2021

AbstractThe methodological principles for assigning benefit points to product elements within a project can also be used at the portfolio level. This allows for the management of entire portfolios towards optimizing benefit over cost. We consider bottom-up assessments from the projects at the portfolio level and top-down assessments at the portfolio level within projects. We revisit the confirmatory and exploratory modes.
Agile Uncertainty Assessment for Benefit Points and Size Points
Authors: Hannay Jo Erskine 
Published: June 2021

AbstractAgile methodology purports to deal with uncertainty through continuous monitoring and learning. To do so, we need to see how productivity is faring against our plans, as in the previous chapter. But we also need to communicate what our uncertainty is realistically. This is regularly done for cost, but must also be done for benefit to obtain a complete picture. In this chapter, we show how both benefit points and size points can be instantiated with values reflecting different levels of uncertainty.
Benefit and Cost Periodized: Stretching Your Points
Authors: Hannay Jo Erskine 
Published: June 2021

AbstractWhen you estimate the life cycle cost and benefit of your software product, your stakeholders should not only be assured that you will deliver value, but also be informed when that value is expected to manifest itself. Periodization is a common method for showing when a return of investment is expected, and one is often careful to express the present value of future cash (net present value) in such deliberations. This chapter shows how to carry out periodization using points. Periodized points then amount to plan templates that can be instantiated with monetary values according to most likely, bad-case, and good-case uncertainty assessments.
Final Remarks
Authors: Hannay Jo Erskine 
Published: June 2021

AbstractBenefit points complement the concept of points-based estimation.We showed how to use points estimates for both benefit and cost in various project and portfolio management activities. One can also adapt a range of other models that we did not cover (see e.g. [3, 1, 2]) to points-based estimates. Points-based estimates give rise to project management templates into which you can instantiate various monetary values, for example, various scenarios according to uncertainty assessments.
Moving Towards Nexus Solutions to ‘Energy’ Problems: An Inclusive Approach
Authors: Hiteva Ralitsa Petrova 
Published: June 2021

AbstractThis chapter offers an innovative approach to examining how fuel poverty in one of the most affected countries in the EU: Bulgaria can be examined as part of the urban nexus of food, water, energy and the environment. Building on bodies of literature of the nexus, fuel poverty, energy transitions and energy geographies, this chapter uses the example of energy provisioning in the capital city of Bulgaria: Sofia to illustrate how a more inclusive approach to addressing fuel poverty and air pollution can be developed. The case study unpacks the urban nexus by examining three practices: urban gardening, making zimnina, and heating and energy use in the home. It illustrates how the interdependencies between the practices of urban gardening, making zimnina and domestic heating and energy use have direct implications for the energy system of provisioning and can be important vectors in the energy transition for vulnerable citizens in the city. The chapter addresses an important research gap in urban nexus literature by offering a compelling empirical account of mapping nexus interactions through the perspective of vulnerable users, focusing on low-technological ways of managing the urban nexus (rather than technologically driven integration across sectors).
Synthesis and application of stationary phase for DNA-affinity chromatographic analysis of unmodified and antisense oligonucleotide
Authors: Studzińska Sylwia , Zawadzka Ewelina , Bocian Szymon , Szumski Michał 
Published: June 2021

AbstractThe goal of the research was the synthesis and application of an oligonucleotide immobilized stationary phase for the analysis of unmodified and antisense oligonucleotides. The method for attaching these molecules to aminopropyl silica modified with pentanedioic acid was developed. Each step of the synthesis was carefully controlled with the application of spectroscopic, elemental, and chromatographic analyses. The oligonucleotide-based stationary phase was applied for the retention studies. Unmodified oligonucleotides of different complementarity to the molecule attached as a stationary phase, as well as antisense oligonucleotides, were tested. The comparative study upon complex optimization of oligonucleotide analysis in different liquid chromatography modes was performed. Results have shown that this stationary phase may be applied for oligonucleotide analysis in hydrophilic interaction liquid chromatography and ion exchange chromatography, but no unique sequence-based selectivity was obtained. Contrary results were observed for affinity chromatography, which allowed for specific separation of the complementary strands based on hydrogen bonding and stacking interactions, where the temperature was the main factor influencing the selectivity of the separation. Furthermore, the oligonucleotide-based stationary phase may be applied for comparative antisense oligonucleotide hybridization studies to a specific RNA sequence. All of the results have shown that affinity chromatography with oligonucleotide-based stationary phases is a powerful technique for the specific base recognition of polynucleotides.
Graphical abstract
Airy Structures for Semisimple Lie Algebras
Authors: Hadasz Leszek , Ruba Błażej 
Published: June 2021

AbstractWe give a complete classification of Airy structures for finite-dimensional simple Lie algebras over$${\mathbb {C}}$$C, and to some extent also over$${\mathbb {R}}$$R, up to isomorphisms and gauge transformations. The result is that the only algebras of this type which admit any Airy structures are$$\mathfrak {sl}_2$$sl2,$$\mathfrak {sp}_4$$sp4and$$\mathfrak {sp}_{10}$$sp10. Among these, each admits exactly two non-equivalent Airy structures. Our methods apply directly also to semisimple Lie algebras. In this case it turns out that the number of non-equivalent Airy structures is countably infinite. We have derived a number of interesting properties of these Airy structures and constructed many examples. Techniques used to derive our results may be described, broadly speaking, as an application of representation theory in semiclassical analysis.
Liver lymphatic anatomy and role in systemic lymphatic disease
Authors: Smith Christopher L. , Liu Mandi , Saravanan Madhumitha , Dewitt Aaron G. , Biko David M. , Pinto Erin M. , Escobar Fernando A. , Krishnamurthy Ganesh , Brownell Jefferson N. , Mamula Petar , Glatz Andrew C. , Gillespie Matthew J. , O’Byrne Michael L. , Ravishankar Chitra , Rome Jonathan J. , Dori Yoav 
Published: June 2021

AbstractObjectivesTo characterize hepatic to systemic lymphatic connections in patients with systemic lymphatic disease using intra-hepatic lymphangiography and to compare outcomes after lymphatic intervention.MethodsIn this retrospective study, patients with intra-hepatic lymphangiography from May 2014 – April 2019 at our institution were included. Imaging review was performed and hepatic lymphatic connections and flow patterns were characterized. Clinical data were reviewed and comparisons between patients undergoing lymphatic intervention with or without abnormal hepatic lymphatics were performed.ResultsDuring the study period, 105 patients underwent intra-hepatic lymphangiography. Primary clinical presentation included ascites (19/105), chylothorax (27/105), plastic bronchitis (PB) (17/105), and protein losing enteropathy (PLE) (42/105). Five categories of hepatic lymphatic connections and flow patterns were identified (%): normal (25%, 26/105), hepatoperitoneal (12%, 13/105), hepatopulmonary (10.5%, 11/105), hepatomesenteric (7.5%, 8/105), and hepatoduodenal (41%, 43/105) with four patients having more than one abnormal pattern. A comparison between clinical presentation and imaging category revealed an increased likelihood of having ascites with hepatoperitoneal (p< .0001), chylothorax/PB with hepatopulmonary (p= .01), and PLE with hepatoduodenal (p< .001) connections. Seventy-six patients had a lymphatic intervention, 24% with normal, and 76% with abnormal liver lymphatics. There was no difference in length of hospital stay or mortality between the two groups, but there was a prolonged time to symptom resolution (p= .006) and persistent symptoms after 6 months (5% vs 44%,p= .002) in the group with abnormal liver lymphatics.ConclusionWe identified five liver lymphatic imaging categories with a substantial correlation to presenting lymphatic disease. Abnormal imaging patterns correlated with increased morbidity. Evaluation of liver lymphatics should be considered in patients with a systemic lymphatic disease if central lymphatic imaging is normal.Key Points•We identified five liver lymphatic imaging patterns: normal, hepatoperitoneal, hepatomesenteric, hepatopulmonary, and hepatoduodenal.•Imaging patterns were correlated with disease presentation (normal – chylothorax/PB, hepatoperitoneal – ascites/chylothorax, hepatopulmonary – chylothorax/PB, hepatoduodenal – PLE).•Abnormal imaging patterns correlated with increased morbidity.
Cardiovascular profiling in the diabetic continuum: results from the population-based Gutenberg Health Study
Authors: Schmitt Volker H. , Leuschner Anja , Jünger Claus , Pinto Antonio , Hahad Omar , Schulz Andreas , Arnold Natalie , Tröbs Sven-Oliver , Panova-Noeva Marina , Keller Karsten , Zeller Tanja , Beutel Manfred , Pfeiffer Norbert , Strauch Konstantin , Blankenberg Stefan , Lackner Karl J. , Prochaska Jürgen H. , Wild Philipp S. , Münzel Thomas 
Published: June 2021

Abstract
Aims
To assess the prevalence of type 2 diabetes mellitus (T2DM) and prediabetes in the general population and to investigate the associated cardiovascular burden and clinical outcome.

Methods and Results
The study sample comprised 15,010 individuals aged 35–74 years of the population-based Gutenberg Health Study. Subjects were classified into euglycaemia, prediabetes and T2DM according to clinical and metabolic (HbA1c) information. The prevalence of prediabetes was 9.5% (n = 1415) and of T2DM 8.9% (n = 1316). Prediabetes and T2DM showed a significantly increased prevalence ratio (PR) for age, obesity, active smoking, dyslipidemia, and arterial hypertension compared to euglycaemia (for all, P < 0.0001). In a robust Poisson regression analysis, prediabetes was established as an independent predictor of clinically-prevalent cardiovascular disease (PRprediabetes 1.20, 95% CI 1.07–1.35, P = 0.002) and represented as a risk factor for asymptomatic cardiovascular organ damage independent of traditional risk factors (PR 1.04, 95% CI 1.01–1.08, P = 0.025). Prediabetes was associated with a 1.5-fold increased 10-year risk for cardiovascular disease compared to euglycaemia. In Cox regression analysis, prediabetes (HR 2.10, 95% CI 1.76–2.51, P < 0.0001) and T2DM (HR 4.28, 95% CI 3.73–4.92, P < 0.0001) indicated for an increased risk of death. After adjustment for age, sex and traditional cardiovascular risk factors, only T2DM (HR 1.89, 95% CI 1.63–2.20, P < 0.0001) remained independently associated with increased all-cause mortality.

Conclusion
Besides T2DM, also prediabetes inherits a significant cardiovascular burden, which translates into poor clinical outcome and indicates the need for new concepts regarding the prevention of cardiometabolic disorders.
Factors associated with a high or low implantation of self-expanding devices in TAVR
Authors: Veulemans Verena , Maier Oliver , Piayda Kerstin , Berning Kira Lisanne , Binnebößel Stephan , Polzin Amin , Afzal Shazia , Dannenberg Lisa , Horn Patrick , Jung Christian , Westenfeld Ralf , Kelm Malte , Zeus Tobias 
Published: June 2021

Abstract
Objectives
Optimizing valve implantation depth (ID) plays a crucial role in minimizing conduction disturbances and achieving optimal functional integrity. Until now, the impact of intraprocedural fast (FP) or rapid ventricular pacing (RP) on the implantation depth has not been investigated. Therefore, we aimed to (1) evaluate the impact of different pacing maneuvers on ID, and (2) identify the independent predictors of deep ID.

Methods
473 TAVR patients with newer-generation self-expanding devices were retrospectively enrolled and one-to-one propensity-score-matching was performed, resulting in a matching of 189 FP and RP patients in each cohort. The final ID was analyzed, and the underlying functional, anatomical, and procedural conditions were evaluated by univariate and multivariate analysis.

Results
The highest ID was reached under RP in severe aortic valve calcification and valve size 26 mm. Multivariate analysis identified left ventricular outflow (LVOT) calcification [OR 0.50 (0.31–0.81) p = 0.005*], a “flare” aortic root [OR 0.42 (0.25–0.71), p = 0.001*], and RP (OR 0.49 [0.30–0.79], p = 0.004*) as independent highly preventable predictors of a deep ID. In a model of protective factors, ID was significantly reduced with the number of protective criteria (0–2 criteria: − 5.7 mm ± 2.6 vs. 3–4 criteria − 4.3 mm ± 2.0; p < 0.0001*).

Conclusion
Data from this retrospective analysis indicate that RP is an independent predictor to reach a higher implantation depth using self-expanding devices. Randomized studies should prove for validation compared to fast and non-pacing maneuvers during valve delivery and their impact on implantation depth.

Trail registration
Clinical Trial registration: NCT01805739.

Graphic abstract
Study design: Evaluation of the impact of different pacing maneuvers (fast ventricular pacing—FP vs. rapid ventricular pacing—RP) on implantation depth (ID). After one-to-one-propensity-score-matching, independent protective and risk factors for a very deep ID beneath 6 mm toward the LVOT (< − 6 mm) were identified. Stent frame pictures as a courtesy by Medtronic®. AVC aortic valve calcification.
Loss-of-function manipulations to identify roles of diverse glia and stromal cells during CNS scar formation
Authors: Wahane Shalaka , Sofroniew Michael V. 
Published: June 2021

AbstractScar formation is the replacement of parenchymal cells by stromal cells and fibrotic extracellular matrix. Until as recently as 25 years ago, little was known about the major functional contributions of different neural and non-neural cell types in the formation of scar tissue and tissue fibrosis in the CNS. Concepts about CNS scar formation are evolving rapidly with the availability of different types of loss-of-function technologies that allow mechanistic probing of cellular and molecular functions in models of CNS disorders in vivo. Such loss-of-function studies are beginning to reveal that scar formation and tissue fibrosis in the CNS involves complex interactions amongst multiple types of CNS glia and non-neural stromal cells. For example, attenuating functions of the CNS resident glial cells, astrocytes or microglia, can disrupt the formation of limitans borders that form around stromal cell scars, which leads to increased spread of inflammation, increased loss of neural tissue, and increased fibrosis. Insights are being gained into specific neuropathological mechanisms whereby specific dysfunctions of different types of CNS glia could cause or contribute to disorder-related tissue pathology and dysfunction. CNS glia, as well as fibrosis-producing stromal cells, are emerging as potential major contributors to diverse CNS disorders either through loss- or gain-of-functions, and are thereby emerging as important potential targets for interventions. In this article, we will review and discuss the effects on CNS scar formation and tissue repair of loss-of-function studies targeted at different specific cell types in various disorder models in vivo.
Oropharyngeal Dysphagia After Hospitalization for COVID-19 Disease: Our Screening Results
Authors: Marchese Maria Raffaella , Ausili Cefaro Carolina , Mari Giorgia , Proietti Ilaria , Carfì Angelo , Tosato Matteo , Longobardi Ylenia , D’Alatri Lucia ,   “Gemelli Against COVID-19 Post-Acute Care Team”
Published: June 2021

AbstractA high percentage of patients suffered symptoms also after recovery from the Coronavirus Disease—2019 (COVID-19) infection. It is not well clear what are the specific long-term sequelae (complications and symptoms). During the acute phase the patients may develop a multi-organ system pathology including aerodigestive tract. As the pathophysiology of COVID-19 emerges, the aim of our study was to describe the prevalence of oropharyngeal dysphagia after COVID-19 disease. From March to July 2020 we enrolled patients recovered from SARS-CoV-2 infection who had been previously hospitalized for the disease. They were screened for dysphagia by mean of the Eating Assessment Tool-10 (EAT-10). The cases with EAT-10 score > 3 were graded for the aspiration risk by applying the Gugging Swallowing Screen (GUSS) and were submitted to the Swal-QoL questionnaire. The cases with a GUSS score > 19 were subjected to FEES. 8/117 (7%) patients had positive screening result. 4/8 (50%) revealed an abnormal health related quality of life in oropharyngeal dysphagia with a mean Swal-QoL score of 69.73. The most affected domain was the “time of meals” (mean score 65) following by the “sleep” (mean score 66) and “eating desire” (mean score 72). 1/8 cases showed increased risk for aspiration and did not showed endoscopic signs of oropharyngeal dysphagia. Our results showed that the prevalence of upper dysphagia after hospitalization for SARS-CoV-2 is not anecdotal and that probably this long-lasting sequela has a psychogenic etiology.
Shunt performance in 349 patients with hydrocephalus after aneurysmal subarachnoid hemorrhage
Authors: Tervonen Joona , Adams Hadie , Lindgren Antti , Elomaa Antti-Pekka , Kämäräinen Olli-Pekka , Kärkkäinen Virve , von und zu Fraunberg Mikael , Huttunen Jukka , Koivisto Timo , Jääskeläinen Juha E. , Leinonen Ville , Huuskonen Terhi J. 
Published: June 2021

AbstractBackgroundShunt-dependent hydrocephalus after aneurysmal subarachnoid hemorrhage (aSAH) is a common sequelae leading to poorer neurological outcomes and predisposing to various complications.MethodsA total of 2191 consecutive patients with aSAH were acutely admitted to the Neurointensive Care at the Kuopio University Hospital between 1990 and 2018 from a defined population. A total of 349 (16%) aSAH patients received a ventriculoperitoneal shunt, 101 with an adjustable valve (2012–2018), 232 with a fixed pressure valve (1990–2011), and 16 a valveless shunt (2010–2013). Clinical timelines were reconstructed from the hospital records and nationwide registries until death (n = 120) or June 2019.ResultsComparing the adjustable valves vs. the fixed pressure valves vs. the valveless shunts, intraventricular hemorrhage was present in 61%, 44% and 100%, respectively. The median times to the shunt were 7 days vs. 38 days vs. 10 days. The rates of the first revision were 25% vs. 32% vs. 69%. The causes included infection in 11% vs. 7% vs. 25% and overdrainage in 1% vs. 4% vs. 31%. The valveless shunt was the only independent risk factor (HR 2.9) for revision. After the first revision, more revisions were required in 48% vs. 52% vs. 45%.ConclusionsThe protocol to shunt evolved over time to favor earlier shunt. In post-aSAH hydrocephalus, adjustable valve shunts, without anti-siphon device, can be installed at an early phase after aSAH, in spite of intraventricular blood, with a modest risk (25%) of revision. Valveless shunts are not recommendable due to high risk of revisions.
A phase I, single-center, open-label study of RM-1929 photoimmunotherapy in Japanese patients with recurrent head and neck squamous cell carcinoma
Authors: Tahara Makoto , Okano Susumu , Enokida Tomohiro , Ueda Yuri , Fujisawa Takao , Shinozaki Takeshi , Tomioka Toshifumi , Okano Wataru , Biel Merrill A. , Ishida Kosuke , Hayashi Ryuichi 
Published: June 2021

Abstract
Background
To determine the safety, preliminary efficacy, pharmacokinetics, and immunogenicity of a single cycle of RM-1929 photoimmunotherapy, an anti-EGFR antibody cetuximab conjugated with a light-activatable dye (IRDye®700DX), in Japanese patients with recurrent head and neck squamous cell carcinoma (rHNSCC).

Methods
Patients received a single fixed dose (640 mg/m2) of RM-1929 and a fixed light treatment dose (50 J/cm2 for superficial illumination; 100 J/cm fiber diffuser length for interstitial illumination). Safety, tumor response (modified RECIST v1.1 by central radiology review), pharmacokinetics, and immunogenicity were evaluated.

Results
Three Japanese patients were enrolled who had failed ≥ 3 prior lines of therapy including radiation, chemotherapy, cetuximab, and immunotherapy. Target lesions were: submental lesion; right superficial cervical node lesion and oropharynx lesion; and external auditory canal lesion. All patients experienced ≥ 1 treatment-emergent adverse event (TEAE), but none were considered dose-limiting. TEAEs were mild to moderate in severity except for one grade 3 application-site pain, which was transient, resolved without sequelae within 24 h, and did not affect study treatment administration. Thirteen of 17 TEAEs reported were possibly or probably related to study treatment. Three patient reports of application-site pain and localized edema were deemed probably related to study treatment. Objective response was observed in two patients (both partial responses). The third patient had disease progression. RM-1929 concentrations and pharmacokinetic parameters were similar in all patients. No patients tested positive for anti-drug antibodies.

Conclusions
RM-1929 photoimmunotherapy showed a manageable safety profile in rHNSCC. Tumor response in these heavily pre-treated patients was clinically meaningful and warrants further investigation.

Clinical trial registration
The trial was registered with the Japanese registry of clinical trials as jRCT2031200133.
Spatial clustering and meso-scale correlates of thyroid disorder among women in India: evidence from the National Family Health Survey (2015–16)
Authors: Singh Shri Kant , Aditi Aditi , Gupta Jitendra 
Published: June 2021

Abstract
Purpose
Thyroid disorders are a major public health burden. Generally, women exhibit higher differentials in the prevalence of these disorders. This study focuses on the socio-economic and behavioural correlates of thyroid disorders along with their spatial clustering among women of reproductive age in India.

Methods
The study uses dataset from the fourth National Family Health Survey (NFHS-4) carried out in 2015–16 to assess self-reported thyroid disorders. Poor–rich ratio (PRR) and concentration index (CI) were used to study the variation in thyroid disorder among women arising out of economic inequality. Moran’s I statistics and bivariate local spatial autocorrelation (BiLISA) maps were used to understand spatial dependence and clustering of thyroid disorder. Spatial lag and error models were applied to examine the correlates of the disorder.

Results
Thyroid disorder prevalence was higher among women from socio-economically better-off households. Adjusted effects showed that users of iodized salt were 1.14 times more likely to suffer from a thyroid disorder as compared to non-users, which is contrary to the general belief that a higher percentage of consumption of iodide salt leads to a lower prevalence of thyroid disorder. A higher autoregressive coefficient (0.71) indicated significantly higher spatial clustering in thyroid disorders.

Conclusions
The prevalence of thyroid disorder in India depends appreciably on spatial and various ecological factors. Sedentary lifestyles among women may be aggravating diseases, which has strong linkage with thyroid disorders. It is strongly recommended to effectively integrate universal salt iodization with activities geared towards the elimination of iodine deficiency disorders.