bluuebunny/crossref_metadata_2025_split huggingface dataset:
IPA1 regulates long anther development through miR156-mediated DNA hyper-methylation and post-transcriptional gene silencing in Oryza longistaminata
Authors: Zhang Guofang , Sun Yue , Huang Tao , Liu Yuqing , Huang Longyu , Zhang Yue , Wang Yanfang , Huang Wenyue , Shao Kuitian , Ding Zhihu , Zhang Zhiyuan , Li Bai , Chen Zhongkai , Wang Zhengjie , Cai Yicong , Zhou Dahu , Ouyang Linjuan , Zhu Changlan , Peng Xiaosong , Xu Jianlong , He Haohua 
Published: December 2024

Abstract

Background: Oryza longistaminata, despite exhibiting robust rhizomes, elongated stamen and resilience against stresses, is unable to achieve self-pollination due to its inability to produce compatible female and male gametes within the same individual plant. Although the observed sterility may appear daunting, the distinct features of elongated anthers, substantial pollen grains, and a big pollen grain count offer breeders a desirable paternal line for hybridization and the intricate biological processes and profound implications during this pivotal stage of anther development remain enigmatic, piquing the curiosity of researchers.
Results: Through a rigorous multi-omics analysis during the anther development from the OlACD to OlAP stage, we discovered intricate correlations between alterations in methylation levels, siRNA variations, and transcriptional regulation within regulatory pathways, and the development of the anther during various fertile stages. This revelation highlights the intricate interplay between epigenetic and siRNA regulation in gene expression modulation. Our analysis pinpointed seven promising candidate genes, with a particular focus on IPA1. Phenotypic alterations in ipa1 mutants and overexpression miR156 revealed contrasting patterns in anther length and abundance and size of pollen grain, while 5’-Azacytidine treatment resulted in the opposite phenotype.
Conclusion: In essence, recent advancements in rice anther development are governed by two mechanisms: miR156-mediated IPA1DNA hyper-methylation leading to transcriptional gene silencing (TGS) and miR156silencing IPA1 expression through degradation and inhibition of complementary IPA1 mRNAs, resulting in post-transcriptional gene silencing (PTGS), both working synergistically to ensure precise regulation of rice anther development.
Temporal trends in novel drug target discovery reveal the increasing importance of human genetic data
Authors: Falaguera Maria J. , McDonagh Ellen M. , Ochoa David , Rusina Polina V. , Roldan-Romero Juan Maria , Hulcoop David G. , Leach Andrew R. , Dunham Ian 
Published: December 2024

Abstract

Drug approvals involving novel mechanism-of-action targets currently account for about one-fifth of new FDA-approved drugs each year. Developing therapies for novel targets carries added risks, but they can significantly address areas with unmet medical needs, or current treatment limitations. The Open Targets Platform is a valuable, regularly updated, open resource for identifying and prioritising therapeutic targets, integrating diverse data sources with a user-friendly interface. However, it lacks assessment of target novelty and has minimal timestamping. In response, we implemented comprehensive timestamping across millions of biomedical data points and introduced a metric to summarise the novelty of a target in the context of disease(s) to discover novel drug targets within the Open Targets ecosystem. A retrospective analysis of novel drug target approvals since 2000 suggests that the genetic evidence for clinical progression is increasingly considered earlier in the pipeline, highlighting the benefit of assessing association evidence in the context of time.
Mechanisms for removing phosphorus species through sequential coagulation using inorganic coagulants and organic polymers
Authors: Koltsova Evelina , Smotraiev Roman , Nehrii Anastasiia , Zhekeev Malik , Ratnaweera Harsha 
Published: December 2024

ABSTRACT

The need for stringent phosphorus removal from domestic wastewater is increasing to mitigate eutrophication, while efficient phosphate reuse is critical due to the global phosphate crisis. Combining aluminum sulfate (ALS) with high molecular weight organic polymers achieved 95–99% removal of particles, turbidity, and phosphates, reducing ALS usage by 40%. We propose mechanisms to explain the enhanced treatment efficiency. Particle and turbidity removal is more influenced by polymer charge density than molecular weight, while orthophosphate (OP) removal is linked to a change in zeta potential from negative to positive, allowing additional OP binding through complex formation with hydrolysis products and polymers. Enhanced phospholipid (PL) removal likely results from adsorption and neutralization of micelle PL charges by intermediate positively charged aluminum hydroxyphosphate ions. Higher PL removal with low ALS doses is attributed to a two-stage dosing process that optimizes coagulant and polymer dosages. The combined removal of OP and PL improves phosphorus bioavailability, increasing the sludge's fertilizer value.
Perkembangan Embrio Ayam Kampung Unggul Balitbangtan (KUB) Dengan In-Ovo Feeding Menggunakan L-Arginin
Authors: Pranatasari Dewi , Zakariya Abu Zaenal 
Published: December 2024

Tujuan dari penelitian ini adalah untuk mengetahui perkembangan embrio ayam KUB dengan in-ovo feeding menggunakan L-Arginin. Penelitian ini dilaksanakan pada bulan Agustus hingga November 2023 di CV Sanjaya Desa Trasan, Kecamatan Bandongan dan di Laboratorium Unggas dan Aneka Ternak, Politeknik Pembangunan Pertanian Yogyakarta – Magelang. Penelitian ini menggunakan rancangan percobaan Rancangan Acak Lengkap (RAL) dengan lima perlakuan dan lima pengulangan dengan per kelompok perlakuan lima butir telur. Data yang diperoleh dianalisis menggunakan analysis of variance (ANOVA). Apabila perlakuan memperlihatkan pengaruh yang nyata maka dilanjutkan dengan uji Duncan’s multiple range test (DMRT). Penelitian ini menggunakan 300 butir telur fertil ayam KUB dengan perlakuan injeksi L-Arginin yaitu P0- sebagai kontrol negatif (tanpa injeksi), P0+ sebagai kontrol positif (injeksi NaCl Fisiologis 0,9%), P1 pemberian L-Arginin 1,5% (1,5 gram per 100 ml NaCl Fisiologis 0,9%), P2 pemberian L-Arginin 2% (2 gram per 100 ml NaCl Fisiologis 0,9%), dan P3 pemberian L- Arginin 2,5% (2,5 gram per 100 ml NaCl Fisiologis 0,9%). Injeksi dilakukan pada hari ke 10 inkubasi dengan diinjeksi 0,5 ml larutan in-ovo feeding. Variabel dalam penelitian ini adalah penyusutan bobot telur, bobot embrio, panjang sayap, panjang kaki, dan lingkar dada. Penelitian ini memberikan hasil yang signifikan (P<0,05) terhadap bobot embrio tetapi tidak signifikan (P>0,05) pada penyusutan bobot telur, panjang sayap, panjang kaki, dan lingkar dada. Kesimpulan dalam penelitian adalah injeksi L-Arginin sebanyak 2,5% dapat meningkatkan bobot embrio.
Impact of Psychological Resilience on the Fear of Pain and Activity Recovery in Postsurgical Patients: Observational Cohort Study
Authors: Luo Yang , Li Sisi , Feng Lijuan , Zheng Junyi , Peng Chunfen , Bao Lihong 
Published: December 2024

Abstract

Background
The fear of pain (FOP) and fear avoidance belief (FAB) play a crucial role in the occurrence and development of chronic pain. However, the dynamics of these factors in postsurgical pain appear to differ, with the FOP often learned from others rather than directly caused by painful experiences. Psychological resilience refers to an individual’s capacity to adapt effectively to adversity, challenges, and threats, and may play a significant role in overcoming the FOP and avoidance behavior.

Objective
The aim of this study was to investigate the role of psychological resilience in overcoming the FOP and avoidance behavior among surgical patients undergoing lung surgery.

Methods
Participants were recruited at the Wuhan Union Hospital. Psychological resilience was measured using the Connor-Davidson Resilience Scale. The FOP was assessed using the simplified Chinese version of the Fear of Pain-9 items. The FAB was measured using the Physical Activity subscale of the Fear-Avoidance Beliefs Questionnaire. Activity recovery was assessed through questions related to social activities and household responsibilities. The adaptive least absolute shrinkage and selection operator (Lasso) regression analysis under nested cross-validation was used to identify key factors affecting postoperative FOP and activity recovery.

Results
A total of 144 participants were included in the final analysis. The results showed that preoperative FOP (coefficient=8.620) and FAB (coefficient=8.560) were mainly positively correlated with postoperative FOP, while psychological resilience (coefficient=−5.822) and age (coefficient=−2.853) were negatively correlated with it. These average R2 of these models was 73% (SD 6%). Psychological resilience was the most important factor in predicting activity recovery, and these models obtained an average accuracy of 0.820 (SD 0.024) and an average area under the curve of 0.926 (SD 0.044).

Conclusions
Psychological resilience was negatively associated with the postoperative FOP and positively with activity recovery in patients who underwent lung surgery. Patients with higher resilience are more likely to cope effectively with postsurgical pain and recover activities sooner. These findings highlight the importance of assessing and potentially enhancing psychological resilience in the perioperative period to improve postoperative outcomes.
Implications of Public Disclosure of Personal Information in a Mobile Alert App for People Living With Dementia Who Go Missing: Qualitative Descriptive Study
Authors: Adekoya Adebusola , Daum Christine , Neubauer Noelannah , Miguel-Cruz Antonio , Liu Lili 
Published: December 2024

Background
People living with dementia are at risk of getting lost and going missing due to memory loss, confusion, and disorientation. Missing person incidents involving people living with dementia are increasing. Alert systems such as Community ASAP can promote community engagement in locating missing persons with dementia and aid in search and rescue efforts. However, the implications of public disclosure of personal information such as name, age, sex, and physical description within such alert systems have yet to be explored.

Objective
This study aimed to identify and discuss the implications of public disclosure of personal information in Community ASAP for people living with dementia at risk of going missing.

Methods
This study used a qualitative descriptive research design drawing from naturalistic inquiry. A total of 19 participants including people living with dementia, care partners, first responders, and service providers were recruited from Ontario, Alberta, and British Columbia, Canada. Semistructured interviews were used to explore participants’ perspectives on the perceived implications of the release of personal information when using Community ASAP. NVivo (version 12) was used to manage data, and conventional content analysis was conducted to identify key themes of the implications of public disclosure of personal information in Community ASAP.

Results
In total, 10/19 (53%) of the participants were women and 9/19 (47%) were men. Of the 19 participants, 3 (16%) were people living with dementia, 5 (26%) were care partners, 4 (21%) were first responders, and 7 (37%) were service providers. In total, 4 key themes were identified as implications of public disclosure of personal information in Community ASAP: right to autonomy, safety versus privacy, informed and knowledgeable consent, and stigmatization. Participants discussed how the public disclosure of personal information in Community ASAP could undermine a person’s choice not to be found and contribute to stigmatization. Participants emphasized a need to balance safety and privacy concerns. Informed and knowledgeable consent is important when using an alert system to locate missing persons with dementia.

Conclusions
Community ASAP can promote community engagement in locating missing persons with dementia. However, the public disclosure of personal information in alert systems has implications. Users’ right to autonomy, a balance between safety and privacy, informed and knowledgeable consent, and risks of stigmatization are perceived impacts of disclosure of personal information in alert systems.
The Impact of Human-Robot Collaboration Levels on Postural Stability During Working Tasks Performed While Standing: Experimental Study
Authors: Bibbo Daniele , Corvini Giovanni , Schmid Maurizio , Ranaldi Simone , Conforto Silvia 
Published: December 2024

Abstract

Background
The integration of collaborative robots (cobots) in industrial settings has the potential to enhance worker safety and efficiency by improving postural control and reducing biomechanical risk. Understanding the specific impacts of varying levels of human-robot collaboration on these factors is crucial for optimizing cobot use.

Objective
This study aims to investigate the biomechanical effects of different levels of human-robot collaboration on postural stability and control during simulated working tasks.

Methods
A total of 14 participants performed simulated cashier working activities under 4 different collaboration modalities, with increasing levels of cobot assistance: full (Fu), half robot touch (HRT), half robot (HRb), and full robot (FRb). Center of pressure trajectories were extracted from 2 force plates’ data to calculate 4 posturography parameters—mean distance (MDIST), mean velocity (MVELO), 95% confidence ellipse area (AREA-CE), and sway area (AREA-SW)—which were analyzed to assess the impact of cobot intervention on postural control.

Results
Nonparametric tests showed significance in the effect of the collaboration modalities on the 4 analyzed parameters. Post hoc tests revealed that FRb modality led to the greatest enhancement in postural stability, with a reduction in MDIST (4.2, SD 1.3 cm in Fu vs 1.6, SD 0.5 cm in FRb) and MVELO (16.3, SD 5.2 cm/s in Fu vs 7.9, SD 1.1 cm/s in FRb). AREA-CE and AREA-SW also decreased significantly with higher levels of cobot assistance (AREA-CE: 134, SD 91 cm² in Fu vs 22, SD 12 cm² in FRb; AREA-SW: 16.2, SD 8.4 cm²/s in Fu vs 4.0, SD 1.6 cm²/s in FRb). Complete assistance of the cobot significantly reduced interindividual variability of all center of pressure parameters. In FRb modality, as compared with all other conditions, removing the weight of the object during loading or unloading phases caused a significant decrease in all parameter values.

Conclusions
Increased cobot assistance significantly enhances postural stability and reduces biomechanical load on workers during simulated tasks. Full assistance from cobots, in particular, minimizes postural displacements, indicating more consistent postural control improvements across individuals. However, high levels of cobot intervention also reduced the natural variation in how people balanced themselves. This could potentially lead to discomfort in the long run. Midlevel cobot assistance modalities can thus be considered as a good compromise in reducing biomechanical risks associated with postural stability at the same time granting a satisfactory level of user control.
Perspectivas e interacciones entre el mundo físico y virtual para los nuevos retos del desarrollo socioeconómico
Authors: Barrera Ortegón Andrea del Pilar , Ávila García Bibiana Del Carmen , Palacio Gaviria Bibiana Patricia , Reyes Fontalvo Carlos Alberto , Pérez Pacheco Camilo Andrés , Trejos Moncayo Carlos Rubén , Valencia Flórez Catherine , Vargas Quintero Cristian Alberto , Cabrera Muñoz Dayra Ibeth , Mejía Álvarez Delvis , Martínez Santos Didier Luisinho , Molano Soto Diego Fernando , Rosado Vanegas Elda Dariana , Hernández Lache Elías , Madariaga Suárez Enilsa , Pinzón Candelario Fanny Matilde , Pulido Bohórquez Gabriel , Medina Ricaurte Germán Fernando , Catherinne Gilma , Castañeda Gilma Catherinne , Giraldo Vargas Guillermo , Paz Jairo Andrés , Fandiño Isaza Jesús Rafael , Muñoz Rojas John Harold , Bustamante Cano John Jairo , Valderrama Fernández Jonny Mauricio , Bello López Julián Felipe , Castillo Garrido Julieth , Manchego Palza Liliana , Arregocés Vanegas Marelbis , Romero Torres Mariano Esteban , Avendaño Avendaño Marilú , Avila Pérez Mario Luis , Quesada Barragán Naryi Xiomara , Celín Giraldo Natalie , Serna Porras Nelson Augusto , Gómez Pedro , Valverde Gómez Oscar Alexander , Gómez Sabogal Pedro , Gamero de la Espriella Pedro Juan , Rodríguez Sebastián , Pitre Redondo Remedios Catalina , González Yolanda 
Published: December 2024

En este libro “Perspectivas e interacciones entre el mundo físico y virtual para los nuevos retos del desarrollo socioeconómico” se presentan capítulos resultados de investigaciones realizadas por docentes investigadores y estudiantes de semilleros de investigación que han indagado sobre emprendimiento digital, mercadeo, gestión y desarrollo organizacional, infraestructura logística, marketing, implicaciones socioeconómicas, innovación tecnológica como parte productiva, social y económica dentro de las organizaciones y en los diferentes contextos regionales, profundizando en temáticas como la gestión empresarial, sociedades modernas, finanzas, donde algunos utilizan la prospectiva y diferentes modelos como complemento de la planeación estratégica para plantear posibles soluciones a las necesidades o problemáticas que se presentan a nivel local, nacional e internacional
Prevalence of Absence of Palmaris Longus in Students of a Medical College in Nepal
Authors: Manandhar Prabina , Sintakala Chandan 
Published: December 2024

Introduction: Palmaris longus is one of the most variable muscles present in the superficial layer of the anterior compartment of forearm and is phylo-genetically categorized as retrogressive muscle. It arises from the medial epicondyle of humerus and forms a long slender tendon which becomes flattened in palm to form palmar aponeurosis and helps in the flexion of hand at wrist. This muscle can be used in plastic surgery or reconstructive surgeries. The present study was carried out to find the prevalence of presence or absence of palmaris longus tendon in Nepalese population so that it would be helpful to provide a baseline data for surgeons to perform surgical procedures. Methods: This was a cross-sectional descriptive study conducted among 200 medical students after the approval from Institutional Review Committee. The presence or absence of tendon of palmaris longus was observed and confirmed on the flexor aspect of wrist by using Schafferâ€™s test and Thompsonâ€™s test. Results: The overall absence of palmaris longus was observed in 55 students (27.5%) with the prevalence of bilateral absence in 27 students (13.5%) and unilateral absence in 28 students (14.0%).The overall absence of palmaris longus was reported in 20 males (23.2%) and in 35 females (30.7%). Conclusion: Absence of palmaris longus (either unilateral or bilateral) was observed in about one fourth of the participants.
Glucose Abnormalities Detected by Continuous Glucose Monitoring in Very Old Adults With and Without Diabetes
Authors: Daya Natalie R. , Fang Michael , Wang Dan , Valint Arielle , Windham B. Gwen , Coresh Josef , Echouffo-Tcheugui Justin B. , Selvin Elizabeth 
Published: December 2024

OBJECTIVE
To characterize the prevalence of continuous glucose monitoring (CGM)-defined glucose abnormalities in a large, community-based population of very old adults (&gt;75 years).

RESEARCH DESIGN AND METHODS
A cross-sectional analysis of 1,150 older adults with and without diabetes who attended the Atherosclerosis Risk in Communities Study (2021–2022). Diabetes was based on a self-reported diagnosis of diabetes by a health care provider, use of diabetes medication, or a hemoglobin A1c (HbA1c) ≥6.5%. Prediabetes was defined as an HbA1c of 5.7% to &lt;6.5% and normoglycemia as an HbA1c of &lt;5.7%. We analyzed CGM metrics, including mean glucose, measures of hyperglycemia, and the coefficient of variation, by diabetes status.

RESULTS
Of the 1,150 participants (mean age 83 years, 59% women, 26% who are Black), 35.1% had normoglycemia, 34.5% had prediabetes, and 30.4% had diabetes. The summary 24-h ambulatory glucose profile for participants with prediabetes was very similar to those with normoglycemia. No participants with normoglycemia or prediabetes had a CGM mean glucose &gt;140 mg/dL, while 32.7% of participants with diabetes had a CGM mean glucose &gt;140 mg/dL.

CONCLUSIONS
In very old adults with normal or prediabetes HbA1c, hyperglycemia detected by CGM was rare. This suggests that HbA1c adequately captures the burden of hyperglycemia for most people in this population.
Sultan Hamengkubawana II and The Dutch In The Political Vortex of the Kasultanan Yogyakarta (1808-1811)
Authors: Mahardi Nasta Ayundra Oktavian 
Published: December 2024

The reign of Sultan Hamengkubawana II in 1808-1811 was full of political turmoil from within and outside the palace. The feud with Daendels was a cold war between the Sultan who was stubborn and unwilling to submit to the Company. The Dutch wanted to create a new order for their colony with the changes they made. Yogyakarta, with Sultan Hamengkubawana II refusing, certainly received some pressure which resulted in unprecedented turmoil. This research will focus on the conflict that occurred between the Sultan and the Dutch. In addition, this research also reviews the internal conflicts that occurred in the palace. The internal conflicts that occurred in the palace also had the role of the Dutch. This research chooses the background time between 1808 and 1811. During this period, the Kasultanan Yogyakarta was in turmoil. In no less than three years, there was a colonial leadership that occupied Java and caused changes that had never happened before. Namely by the French-Dutch envoy, Herman Willem Daendels as Governor General of the Dutch East Indies. The analysis of this period is quite important considering that Yogyakarta would experience a new era of governmental order in a relatively short period of time.