bluuebunny/crossref_metadata_2025_split huggingface dataset:
Half-Lantern Cyclometalated Platinum(II) Complexes as Anticancer Agents: Molecular
Docking, Apoptosis, Cell Cycle Analysis, and Cytotoxic Activity Evaluations
Authors: Hajipour Fatemeh , Mahdavinia Masoud , Fereidoonnezhad Masood 
Published: July 2021

Background and Objective:
In the design of modern metal-based anticancer drugs, platinum-based complexes
have gained growing interest. In this study, the anticancer activity of half-lantern cyclometalated Pt(II)‒Pt(II)
complexes was evaluated using MTT, apoptosis, cell cycle analysis, and DNA binding studies.

Materials and Methods:
The cytotoxicity of Pt(II)‒Pt(II) complexes were evaluated against different cancer cell lines,
such as human lung (A549), breast (MCF-7, and MDA-MB-231), ovarian (SKOV-3), and colon (HT-29) as well as
normal breast (MCF-10A), and human lung fibroblast (MRC-5) cells using MTT assay. BioLegend's PE Annexin, V
Apoptosis Detection Kit with 7AAD, was applied to assess the apoptotic effects of 1A and 1B compound against
MCF-7 and A549 cell lines. Cell cycle analysis was determined using the flow cytometry method. The interaction of
compounds with four different DNA structures with PDB codes (1BNA, 1LU5, 3CO3, and 198D) has been investigated
by molecular docking. To achieve binding to DNA experimentally, the electrophoresis mobility shift assay and
comet assay were applied.

Results:
In the evaluation of cytotoxic effects, 1A showed the highest cytotoxicity among the studied compounds, and
it showed higher potency with more selectivity against normal cell lines than cisplatin. This compound had IC50 of
7.24, 2.21, 1.18, 2.71, 10.65, 18.32, and 49.21 μM against A549, SKOV3, HT29, MCF-7, MDA-MB-231, MRC-5, and
MCF-10A, respectively, whereas cisplatin had IC50 of 9.75, 19.02, 107.23, 15.20, 18.09, 14.36, and 24.21 μm, respectively,
on the same cell lines. In order to check the DNA binding activity of 1A, and 1B, electrophoretic mobility was
also conducted, which indicated that the binding of these compounds led to a slight change in electrophoretic mobility
to DNA. The migration of chromosomal DNA from the nucleus in the form of a tail or comet was executed in the
comet assay of 1A on MCF-7. Examination of apoptosis of 1A and 1B on the MCF-7 cancer cell line showed that it
could increase induction of apoptosis in this cancerous cell in a concentration-dependent manner. Investigating the
effect of 1A using cell cycle analysis on MCF-7 cancer cell line showed that this complex affects stage G1 and S of the
cell cycle.

Conclusion:
1A has the potential to play a significant role in future biopharmaceutical studies.
Initial Investigation of Athletes’ Electrocardiograms Acquired by Wearable Sensors during the Pre-exercise Phase
Authors: Romagnoli Sofia , Sbrollini Agnese , Colaneri Massimo , Marcantoni Ilaria , Morettini Micaela , Zitti Gianluca , Brocchini Maurizio , Pozzi Marco , Burattini Laura 
Published: July 2021

Aim:
The aim of this study is to support large-scale prevention programs fighting sport-related sudden cardiac death by providing a set of electrocardiographic features representing a starting point in the development of normal reference values for the pre-exercise phase.

Background:
In people with underlying, often unknown, cardiovascular abnormalities, increased cardiovascular load during exercise can trigger sport-related sudden cardiac death. Prevention remains the only weapon to contrast sport-related sudden cardiac death. So far, no reference values have been proposed for electrocardiograms of athletes acquired with wearable sensors in the pre-exercise phase, consisting of the few minutes immediately before the beginning of the training session.

Objective:
To perform an initial investigation of athletes’ electrocardiograms acquired by wearable sensors during the pre-exercise phase.

Methods:
The analyzed electrocardiograms, acquired through BioHarness 3.0 by Zephyr, belong to 51 athletes (Sport Database and Cycling Database of the Cardiovascular Bioengineering Lab of the Università Politecnica delle Marche, Italy). Preliminary values consist of interquartile ranges of six electrocardiographic features which are heart rate, heart-rate variability, QRS duration, ST level, QT interval, and corrected QT interval.

Results:
For athletes 35 years old or younger, preliminary values were [72;91]bpm, [26;47]ms, [85;104]ms, [-0.08;0.08]mm, [326;364]ms and [378;422]ms, respectively. For athletes older than 35 years old, preliminary values were [71;94]bpm, [16;65]ms, [85;100]ms, [-0.11;0.07]mm, [330;368]ms and [394;414]ms, respectively.

Conclusion:
Availability of preliminary reference values could help identify those athletes who, due to electrocardiographic features out of normal ranges, are more likely to develop cardiac complications that may lead to sport-related sudden cardiac death.
Dynamic Monitoring of an Existing Reinforced Concrete Building in Naples Port Area
Authors: Bencivenga Pasquale , Chisari Corrado , Dell’Aversano Costantino , Pasquino Vittorio , Ferraioli Massimiliano , Vasaturo Adele , De Matteis Gianfranco 
Published: July 2021

Introduction:
The conservation and preservation of existing buildings, in particular public infrastructures, is currently a significant issue in Italy and Europe, considering their strategic role and the risk represented by human losses, management issues and also economic disruption in case of collapse.
In this context, the interest in conservation is not restricted to monumental or artistical buildings but also includes the several buildings composing the Italian infrastructural heritage, which in many cases are made of reinforced concrete and show signs of ageing after half a century and more from their construction.

Methods:
On the basis of these premises, in the present paper, a preliminary investigation on an infrastructural case study located in Naples port is presented. Such a study is part of a research activity aimed at defining critical structural issues of the central administrative building of the Central Tyrrhenian Sea Port System Authority.

Results:
A system of high-sensitivity and low-cost MEMS acceleration sensors were installed on the structure, with the aim of investigating its dynamic behaviour. A Finite Element model of the building was created, including information about material properties and cross-section details from prior experimental activities. A model updating procedure was carried out, based on the dynamic data collected by the monitoring system and post-processed to estimate the fundamental frequencies.

Conclusion: This has allowed highlighting the main features of the dynamic response of the building, and the critical role played by deformability of infill panels and floors on the modal properties of the structure.
Producing Sustainable Concrete using Nano Recycled Glass
Authors: Abbas Zena K. , Mahdi Hayder A. , Tayeh Bassam A. 
Published: July 2021

Background:
Many tools and techniques have been recently adopted to develop construction materials that are less harmful and friendlier to the environment. New products can be achieved through the recycling of waste material. Thus, this study aims to use recycled glass bottles as sustainable materials.

Objective:
Our challenge is to use nano glass powder by the addition or replacement of the weight of the cement for producing concrete with enhanced strength.

Methods:
A nano recycled glass powder is prepared by crushing and storming a glass bottle to obtain a Blaine surface area of approximately 28 m2/g and conforming to the chemical requirements for natural pozzolana class N, according to ASTM C618. The outcome of using nano recycled glass for theaddition and replacement of ordinary Portland cement weight on the compressive and flexural strengths of concrete at 7, 28, and 90 days is investigated.

Results:
The concrete mixes with 2.5%, 5%, 7.5%, and 10% replacements of cement by nano recycled glass powder show improvements in compressive and flexural strengths of up to 12.77% and 7.66%, respectively, at 28 days. Meanwhile, mixes with the addition of 5% nano glass powder show best improvements in compressive and flexural strengths of up to 11.49% and 7.46%, respectively.
A Novel Analog Circuit Fault Diagnosis Approach
Authors: Zhang Chaolong , Ye Lingling , Wu Jing , Zhang Bo , Yao Ningguang , Wang Yuanzhi 
Published: July 2021

Background:
Correct classifying of analog circuit faults is helpful in the health management
of the circuit. It is difficult to be implemented because of the lack of proper feature extraction
methods and accurate fault diagnosis models.

Objective:
T-SNE based core components extraction method and PSO-ELM-based fault diagnosis
model are presented to improve the diagnostic accuracy of analog circuit fault diagnosis.

Methods:
Firstly, circuit output signals are collected, and they are transformed to wavelet coefficients.
Then, the high-dimensional wavelet coefficients are processed by t-SNE to generate lowdimensional
core components as features. The Extreme Learning Machine (ELM) based diagnosing
model is constructed by using the features, and the key parameters of ELM are optimized by using
Particle Swarm Optimization (PSO) algorithm. Finally, the constructed PSO-ELM diagnosis model
is employed to identify different analog circuit faults.

Results:
Leapfrog filter circuit and three-phase bridge circuit fault diagnosis experiments are implemented
to demonstrate the proposed t-SNE based features extraction method and PSO-ELM
based fault diagnosis model. Also, comparisons are performed to verify the high performance of
proposed fault diagnosis methods.

Conclusion:
The proposed t-SNE based core components extraction method and PSO-ELM diagnosis model are effective to improve the fault diagnosis accuracy of the analog circuit.
Quantifying Online News Media Coverage of the COVID-19 Pandemic: Text Mining Study and Resource
Authors: Krawczyk Konrad , Chelkowski Tadeusz , Laydon Daniel J , Mishra Swapnil , Xifara Denise , Gibert Benjamin , Flaxman Seth , Mellan Thomas , Schwämmle Veit , Röttger Richard , Hadsund Johannes T , Bhatt Samir 
Published: July 2021

BackgroundBefore the advent of an effective vaccine, nonpharmaceutical interventions, such as mask-wearing, social distancing, and lockdowns, have been the primary measures to combat the COVID-19 pandemic. Such measures are highly effective when there is high population-wide adherence, which requires information on current risks posed by the pandemic alongside a clear exposition of the rules and guidelines in place.ObjectiveHere we analyzed online news media coverage of COVID-19. We quantified the total volume of COVID-19 articles, their sentiment polarization, and leading subtopics to act as a reference to inform future communication strategies.MethodsWe collected 26 million news articles from the front pages of 172 major online news sources in 11 countries (available online at SciRide). Using topic detection, we identified COVID-19–related content to quantify the proportion of total coverage the pandemic received in 2020. The sentiment analysis tool Vader was employed to stratify the emotional polarity of COVID-19 reporting. Further topic detection and sentiment analysis was performed on COVID-19 coverage to reveal the leading themes in pandemic reporting and their respective emotional polarizations.ResultsWe found that COVID-19 coverage accounted for approximately 25.3% of all front-page online news articles between January and October 2020. Sentiment analysis of English-language sources revealed that overall COVID-19 coverage was not exclusively negatively polarized, suggesting wide heterogeneous reporting of the pandemic. Within this heterogenous coverage, 16% of COVID-19 news articles (or 4% of all English-language articles) can be classified as highly negatively polarized, citing issues such as death, fear, or crisis.ConclusionsThe goal of COVID-19 public health communication is to increase understanding of distancing rules and to maximize the impact of governmental policy. The extent to which the quantity and quality of information from different communication channels (eg, social media, government pages, and news) influence public understanding of public health measures remains to be established. Here we conclude that a quarter of all reporting in 2020 covered COVID-19, which is indicative of information overload. In this capacity, our data and analysis form a quantitative basis for informing health communication strategies along traditional news media channels to minimize the risks of COVID-19 while vaccination is rolled out.
Using Telehealth to Deliver Primary Care to Adolescents During and After the COVID-19 Pandemic: National Survey Study of US Primary Care Professionals
Authors: Gilkey Melissa B , Kong Wei Yi , Huang Qian , Grabert Brigid K , Thompson Peyton , Brewer Noel T 
Published: July 2021

Background
The COVID-19 pandemic has led to unprecedented use of telehealth, including by primary care professionals (PCPs) who serve adolescents.

Objective
To inform future practice and policies, we sought to characterize PCPs’ recent experience using adolescent telehealth as well as their support for it after the COVID-19 pandemic is over.

Methods
From February to March 2021, we conducted a web-based survey of 1047 PCPs in the United States. Our national sample included physicians (747/1047, 71%), advanced practice providers (177/1047, 17%), and nurses (123/1047, 12%) who provided primary care to adolescents aged 11-17 years.

Results
Most PCPs reported using telehealth for a low, moderate, or high proportion of their adolescent patients in the three months prior to the survey (424/1047, 40%, 286/1047, 27%, and 219/1047, 21%, respectively); only 11% (118/1047) reported no use. A majority of respondents agreed that adolescent telehealth increases access to care (720/1047, 69%) and enables them to provide high-quality care (560/1047, 53%). Few believed that adolescent telehealth takes too much time (142/1047, 14%) or encourages health care overuse (157/1047, 15%). Most supported giving families the option of adolescent telehealth for primary care after the pandemic is over (683/1047, 65%) and believed that health insurance plans should continue to reimburse for telehealth visits (863/1047, 82%). Approximately two-thirds (702/1047, 67%) wanted to offer adolescent telehealth visits after the pandemic, with intentions being higher among those with recent telehealth experience (P<.001).

Conclusions
PCPs in our national sample reported widespread use of and predominantly positive attitudes toward adolescent telehealth. Our findings also suggest broad support among PCPs for continuing to offer adolescent telehealth after the COVID-19 pandemic ends.
DESIGN, OPTIMIZATION AND EVALUATION OF ACECLOFENAC FAST DISSOLVING TABLETS EMPLOYING STARCH VALERATE–A NOVEL SUPERDISINTEGRANT
Authors: SANTOSH KUMAR R. , KANDUKURI SHAMBHAVI , RAMYA M. , LATHA B. KUSUMA 
Published: July 2021

Objective: To synthesize, characterize and evaluate starch valerate as a superdisintegrant in the formulation of aceclofenac fast dissolving tablets by employing 23 factorial design.
Methods: Starch valerate was synthesized and its physical and micromeritic properties were performed to evaluate it. The fast dissolving tablet of aceclofenac was prepared by employing starch valerate as a superdisintegrant in different proportions in each case by direct compression method using 23 factorial design for evaluation of tablet parameters like disintegration and dissolution efficiency in 5 min.
Results: The starch valerate prepared was found to be fine, amorphous and free flowing. Starch valerate exhibited good swelling in water with swelling index (125.2%). The study of starch valerate was shown by fourier transform infrared spectra (FTIR). The drug content (200±5%), hardness (3.5–4 kg/sq. cm), and friability (<0.15%) has been effective with regard to all the formulated fast dissolving tablets employing starch valerate. The disintegration time of all the formulated tablets was found to be in the range of 14±0.04 to 25.7±0.02 sec. The optimized formulation F4 had the least disintegration time i.e., 12.8±0.02 sec. The wetting time of the tablets was found to be in the range of 76±0.21 to 217±0.17s. The In vitro wetting time was less (i.e., 28±0.02s) in optimized formulation F4. The water absorption ratio of the formulated tablets was found to be in the range of 46±0.12 to 100±0.27%. The percent drug dissolved in the optimized formulation F8 was found to be 99.93% in 5 min.
Conclusion: Starch valerate, when combined with sodium starch glycolate, croscarmellose sodium, with aceclofenac, was found to be an effective super disintegrant which improved the dissolution efficiency and could therefore be used in the formulation of quick dissolving tablets to provide immediate release of the contained drug within 5 min.
THE EFFECT OF BANGGAI YAM (DIOSCOREA ALATA L.) MODIFICATION ON FILM CHARACTERISTICS AS A FILM COATING MATERIAL FOR MODIFIED RELEASE DOSAGE FORMS
Authors: YUSRIADI  , SULASTRI EVI , ATHIYAH  , AANISAH NUUR 
Published: July 2021

Objective: This study aims to determine the effect of modification of Banggai yam (Dioscorea alata L.) as a coating agent in modified release drug based on the film characteristics.
Methods: Banggai yam starch was physically modified to produce pregelatinized Banggai yam starch (PGBYS) powder as well as chemically to produce pregelatinized Banggai yam starch phthalate (PGBYSP). Powder obtained was each physically and chemically characterized including organoleptics, morphology, tapped density, water content content and degree of substitution. Furthermore, the formulation was made to produce film-coated drug with the same coating agent concentration in 2 formulas: F1 (PGBYSP 6 %) and F2 (PGBYS 6 %).
Results: The results were then evaluated including organoleptics, film thickness, morphology, mechanical strength, and film solubility. Results of evaluation showed that film thickness values for both formulas, ​​F1 and F2 respectively, were 0.13±0.020 mm and 0.18±0.005 mm. Mechanical strength included tensile strength consecutively at values of F1= 0.08±0.005 MPa and F2= 0.27±0.05 MPa; % elongation of F1= 114.16±11.8 % and F2= 164.06±57.94%; Young's modulus of F1= 7.3×104±9.8×10-5 MPa and F2= 1.8×103±7.9×10-4 MPa. The solubility of the film-coating in HCl pH 1.2 medium for F1 was 7.9±1.92% and F2 was 25.8±2.42%. In pH 6.8 medium, F1 was 8.6±2.27% and F2 was 11.6±1.44%, while in pH 7.4 medium, F1 was 19.1±5.46% and F2 was 13.1±1.78%. Both film-coated formulas were soluble in alkaline medium, but F2 could not maintain its conditions in acid medium. This proves that the chemical modification product by esterification to form a film can withstand acidic medium.
Conclusion: Therefore, PGBYSP has potential to be used as a coating agent in controlled release drug.
A NOVEL NANOGEL FORMULATION OF FINASTERIDE FOR TOPICAL TREATMENT OF ANDROGENETIC ALOPECIA: DESIGN, CHARACTERIZATION AND IN VITRO EVALUATION
Authors: SANGANABHATLA DIVYA , SUNDER R. SHYAM 
Published: July 2021

Objective: The present paper describes the development and evaluation of a Novel Finasteride (FSD) nanogel topical delivery for the treatment of Androgenetic Alopecia. Nano-based topical formulation was chosen to enhance the solubility, permeability, biocompatibility of drug and to overcome the problems associated with the oral delivery of finasteride.
Methods: Various trails batches were prepared by using probe sonication method. Based on stability studies and particle size, NP4 trail was optimized which exhibited a spherical shape with a mean diameter of 113.80±0.72, the polydispersity of 0.28±0.01, zeta potential of-25.2 mV, drug entrapment efficiency of 92.67±0.47 %, and drug loading of 6.15±0.02 %. Storage stability studies demonstrated that the particle size and entrapment efficiency were not changed during 3 mo both at 4 °C and room temperature. Finasteride (FSD) NLCs were characterized for particle size by scanning electron microscope (SEM), chemical state by X-Ray diffraction (XRD), physical stability by centrifugation and thermodynamic stability by Freeze-thaw method. These prepared nanoparticles were transformed into topical nanogel and further evaluated.
Results: Among the different trails, C2 trail of NLC gel has shown excellent gelling capacity, clear appearance, good viscosity characteristics and was selected for further evaluation studies. Batches of topical nanogel were characterized through pH, homogeneity, spreadability, viscosity, drug content and in vitro drug release study. Based on pH (6.5-6.8), drug content (91.25±0.9%), spreadability (6.7 cm/sec), C2 batch was subjected to In vitro skin occlusivity study, in-vitro release study and In vitro heamolysis study.
Conclusion: The percent cumulative drug release for Finasteride (FSD) gel was found to be 758.52±1.49 µg at 24 h which is quite higher than plain gel and Finasteride (FSD) gel showed maximum occlusiveness and excellent spreadability and found to be stable. In conclusion, prepared Finasteride (FSD) Nanogel could be used with promising potential for the treatment of Androgenetic Alopecia.
PRELIMINARY STUDY ON THE IMPACT OF POLYMER-LIPID TYPES AND RATIO TO POLYMERIC-LIPID HYBRID NANOPARTICLE
Authors: PUSPITA OKTAVIA EKA , WIDODO FERRI , PUTRI MONICA ANDIKA , ROSSARIZA ISWA , FADHILLA AVIOLA , SARI NI PUTU JUNITA 
Published: July 2021

Objective: This study aims to determine the best lipid to polymer ratios in polymeric-lipid nanoparticles using various types and ratios of polymers and lipids.
Method: Polymeric-lipid nanoparticle was prepared using the modified one-step nanoprecipitation method. This study used chitosan and Na alginate as polymers and lecithin and egg phosphatidylcholine as lipids. The lipid was crossed-combined with polymer in various ratios, i. e 12.5%, 25.0%, and 37.5%. On its preparation, Cinnamomum burmanii extract was loaded into the resulted polymeric-lipid nanoparticle as an active substance model. The results were assessed its particle surface characteristics including particle size, polydispersity index, and zeta potential.
Results: Twelve formulas resulted from crossed-combination between the lipid and polymer were used in this study. Polymeric-lipid nanoparticles resulted from the combination of egg phosphatidylcholine/Na alginate has particle size, polydispersity index, and zeta potential of 380.07±3.52 nm, 0.66±002, and-30.6±1.15 mV, respectively.
Conclusions: The best lipid to polymer ratio and type was observed in egg phosphatidylcholine: Na alginate. The particle surface characteristics were better compared to other combinations.