bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISA MOVEMENT FUEL MENGGUNAKAN QUALITY CONTROL CIRCLE (QCC) UNTUK MENGURANGI NG NO CONECTION DI PT. INS
Authors: Dahniar Tedi 
Published: March 2021

ABSTRAK PT. Indonesia Nippon Seiki adalah perusahaan manufaktur yang sudah menerapkan sistem pengendalian mutu, tidak serta merta mencapai zero defect. Penelitian ini bertujuan untuk memperbaiki sistem pengendalian mutu menuju zero defect. Penelitian dilakukan pada sebuah perusahaan yang memproduksi komponen otomotif roda dua. Penelitian menerapkan metode Failure Methode and Effect Analysis (FMEA) untuk mengidentifikasi masalah utama cacat produk, penyebab dan dampaknya. FMEA dilakukan dengan menggunakan data produksi selama 3 tahun pada 3 pabrik perakitan disertai observasi lapangan dan wawancara dengan personil – personil kunci disetiap pabrik. Hasil penelitian menunjukan bahwa perbaikan perlu dilakukan pada unsur mesin, manusia, metode dan lingkungan, setelah perbaikan dilakukan pada ke empat unsur tersebut produk gagal atau reject dan claim pun dapat diturunkan. Kata kunci : Failure Mode and Effect Analysis (FMEA), Reject , ZeroDefect
MASYARAKAT INDUSTRI DAN HUMANIS-RELIGIUS (Studi Kasus di Balaraja Banten)
Authors: Mualif M. 
Published: March 2021

ABSTRAK Balaraja merupakan salah satu daerah sentra industri, keterlibatan penduduk sektor ekonomi di kecamatan Balaraja sebagian besar bekerja di sektor industri. Industrialisasi dan modernisasi berimplikasi pada nilai-nilai sekuleritas dan target produktifitas masyarakatnya, oleh sebagian pakar keilmuan bertolak belakang dengan nilai-nilai keagamaan yang bersifat sakral.Akan tetapi apa yang terjadi di Balaraja tepatnya di Desa Tobat justru sebaliknya, industrialisasi memang telah merubah sector ekonomi masyarakat sekitar dari masyarakat agraris tradisional dan peternak hewan menjadi masyarakat Industri yang dituntun akan target produktifitas di pabrik mereka bekerja. Namun industrialisasi tidak serta merta mengikis nilai-nilai humanis dan religiusitas dalam kehidupan masyarakat sehari-hari. Justru hasil penelitian ini menemukan bahwa nilai-nilai humanis dan religious desa Tobat Kecamatan Balaraja justru mengalami peningkatan, disamping peningkatan pendapatan dan taraf ekonomi di daerah tersebut. Kata Kunci: Masyarakat Industri, Humanis-Religius
Right Ventricular Myocardial Infarction and Adverse Events from Nitrates: A Narrative Review
Authors: Wilkinson-Stokes Matt 
Published: March 2021

Introduction There is ubiquitous belief that right ventricular myocardial infarction (RVMI) patients are pre-load dependent, and that administering nitrates to this cohort may cause adverse events – most notably hypotension. This article charts a narrative history of RVMI and nitrates: from the initial recognition of RVMI and early support of the use of nitrates, through the spread of the view against nitrates, and to the recent publication of evidence once again supporting their use. Methods Four databases were systematically searched (PubMed, Embase, Medline, Web of Science) and results screened by title, then abstract, and finally full text. Results were presented using a chronological narrative structure. Results The view against the use of nitrates during RVMI can be traced back to a single 1989 cohort study of 28 patients, then later being adopted by a series of influential secondary evidence papers, and ultimately by international guidelines. In 2016, 2017 and 2019, new cohort studies totalling 1046 patients were presented, all of which concluded that nitrates are safe to administer during RVMI. Conclusion This article charts how a single retrospective cohort study with low statistical power came to form the dominant narrative on best practice despite complex and conflicting primary evidence.
Avaliação de isolados de rizóbios tolerantes a acidez in vitro na simbiose com feijão Caupi (Vigna unguiculata L. Walp.) em Latossolo Amarelo
Authors: Hara Francisco Adilson dos Santos , Lopes Sophia Kathleen da Silva , Silva Theoderic Shay Botelho da , Vendruscolo Jhony , Mendes Angela  Maria da Silva , Inácio Ariele Cristine Ferreira , Souza Luiz Carlos Costa de 
Published: March 2021

A baixa concentração de N nos solos agrícolas da Amazônia é um fator limitante para uma agricultura econômica e ecologicamente sustentável, logo, constata-se a grande importância da fixação biológica para suprir a demanda deste macronutriente nos ecossistemas. O presente trabalho tem como objetivo, avaliar a capacidade infectiva de isolados de rizóbio e a eficiência na fixação do nitrogênio em um Latossolo Amarelo. O experimento foi instalado em delineamento inteiramente ao acaso, com esquema fatorial de 6 (4 Inoculantes e sem nitrogênio, 1 sem inoculantes e com nitrogênio, e 1 sem inoculante e sem nitrogênio) x 2 (calagem e sem calagem) em 4 repetições, perfazendo um total de 48 parcelas experimentais. A calagem aumentou a eficiência dos isolados e dos rizóbios nativos do solo em nodularem as plantas de caupi e estimularem o crescimento da biomassa. Os rizóbios nativos do solo apresentaram eficiência simbiótica semelhante aos isolados usados como inoculantes. O Isolado FCAN07B se equiparou à adubação nitrogenada em relação a proporcionar ganho de biomassa nas plantas de caupi. A dose de 20 kg ha-1 de nitrogênio foi deletéria para a nodulação do feijão caupi.
ANALISIA HIDROGRAF SATUAN DAN WIND ROSE PLOTS PADA DAERAH ALIRAN SUNGAI SEKANAK
Authors: Destania Henggar Risa , Syarifudin Achmad 
Published: March 2021

Sekanak watershed is a basin in Palembang which is often affected by flood during the rainy season. The characteristics of the watershed by the impact of changes in land-use by economic and settlement developments. Sekanak watershed has 3 retention ponds which have the function of accommodating temporary discharge during floods. The catchment capacity of the watershed soil type, storage conditions etc. Therefore we need an analysis of the transformation of rainfall data in the watershed into a flow at the watershed control point and an analysis of the transformation of runoff volume (effective rain) into a surface runoff hydrograph (unit hydrograph). Hydrographs measured at a watershed control point are the response or output from rain that falls on a watershed system. The size of the watershed depend on the watershed system. This is closely related in analyzing the availability of water that occurs in the watershed system.
Inspección y rehabilitación de puentes atirantados en la red de carreteras del Estado.
Authors: Criado Morán Emilio , Navareño Rojo Alvaro 
Published: March 2021

En este artículo se describe la experiencia de los últimos años en la inspección y la ejecución de obras de rehabilitación de puentes atirantados pertenecientes a la Red de Carreteras del Estado, que gestiona directamente la Dirección General de Carreteras dependiente del Ministerio de Transportes Movilidad y Agenda Urbana.
Durante los últimos años la Dirección General de Carreteras ha promovido la realización de numerosas inspecciones de puentes en su red de carreteras. Gracias a estas inspecciones se pudieron detectar deterioros significativos en cuatro de sus puentes atirantados más antiguos: el puente de Amposta, el puente de Fernando Reig en Alcoy, el puente del Centenario en Sevilla y el Puente Internacional sobre el río Guadiana, en Ayamonte. Esta detección precoz ha permitido realizar o proyectar en dichas estructuras las actuaciones de rehabilitación y sustitución de tirantes necesarias para garantizar la seguridad de los usuarios.
Por lo tanto, es necesario destacar la importancia de realizar inspecciones especiales en los puentes atirantados construidos en España, ya que van alcanzando sus primeros 30-40 años de vida útil, para poder detectar la necesidad de reemplazar o sustituir algunos de sus elementos más vulnerables, como puede ser el sistema de atirantamiento.
Immunogenicity Risk Profile of Nanobodies
Authors: Ackaert Chloé , Smiejkowska Natalia , Xavier Catarina , Sterckx Yann G. J. , Denies Sofie , Stijlemans Benoit , Elkrim Yvon , Devoogdt Nick , Caveliers Vicky , Lahoutte Tony , Muyldermans Serge , Breckpot Karine , Keyaerts Marleen 
Published: March 2021

Nanobodies (Nbs), the variable domains of camelid heavy chain-only antibodies, are a promising class of therapeutics or in vivo imaging reagents entering the clinic. They possess unique characteristics, including a minimal size, providing fast pharmacokinetics, high-target specificity, and an affinity in the (sub-)nanomolar range in conjunction with an easy selection and production, which allow them to outperform conventional antibodies for imaging and radiotherapeutic purposes. As for all protein theranostics, extended safety assessment and investigation of their possible immunogenicity in particular are required. In this study, we assessed the immunogenicity risk profile of two Nbs that are in phase II clinical trials: a first Nb against Human Epidermal growth factor Receptor 2 (HER2) for PET imaging of breast cancer and a second Nb with specificity to the Macrophage Mannose Receptor (MMR) for PET imaging of tumor-associated macrophages. For the anti-HER2 Nb, we show that only one out of 20 patients had a low amount of pre-existing anti-drug antibodies (ADAs), which only marginally increased 3 months after administering the Nb, and without negative effects of safety and pharmacokinetics. Further in vitro immunogenicity assessment assays showed that both non-humanized Nbs were taken up by human dendritic cells but exhibited no or only a marginal capacity to activate dendritic cells or to induce T cell proliferation. From our data, we conclude that monomeric Nbs present a low immunogenicity risk profile, which is encouraging for their future development toward potential clinical applications.One Sentence SummaryNanobodies, the recombinant single domain affinity reagents derived from heavy chain-only antibodies in camelids, are proven to possess a low immunogenicity risk profile, which will facilitate a growing number of Nanobodies to enter the clinic for therapeutic or in vivo diagnostic applications.
A Comparative Study for License Application Regulations on Proprietary Chinese Medicines in Hong Kong and Canada
Authors: Zhong Linda L. D. , Lam Wai Ching , Lu Fang , Tang Xu Dong , Lyu Aiping , Bian Zhaoxiang , Boon Heather 
Published: March 2021

Ethnopharmacological Relevance: Chinese Medicine plays a symbolic role among traditional medicines. As Chinese Medicine products are widely used around the globe, regulations for Chinese Medicine products are often used as models for the efficient regulation of natural products that are safe, and high-quality.Aim of the Study: We aimed to compare the regulatory registration requirements for Proprietary Chinese Medicines in Hong Kong and Canada.Materials and Methods: We compared registration requirements for Proprietary Chinese Medicine in Hong Kong and Canada based on publicly available information provided by the respective Regulators. A marketed product, Zhizhu Kuanzhong Capsule (SFDA approval number Z20020003; NPN approval number 80104354), was used as a case study to demonstrate the similarities and differences of the requirements in both Hong Kong and Canada.Results: There were similarities and differences between the two regulatory systems in terms of the quality, safety and efficacy requirements. Despite the superficial appearance of similar categories and groups/classes, Hong Kong requires significantly more primary test data compared to Canada's reliance on attestation to manufacturing according the standards outlined in approved reference pharmacopeias/texts.Conclusion: Improved understand of the similarity and differences will enable applicants to plan appropriate strategies for gaining product approval. Exploring ways to harmonize the regulatory process has the potential to benefit manufacturers, regulators, and patients by increasing efficiency and decreasing costs.
Clinical Characteristics and Outcome of Neuronal Surface Antibody-Mediated Autoimmune Encephalitis Patients in a National Cohort
Authors: Hayden Zsófia , Bóné Beáta , Orsi Gergely , Szots Monika , Nagy Ferenc , Csépány Tünde , Mezei Zsolt , Rajda Cecília , Simon Diána , Najbauer József , Illes Zsolt , Berki Timea 
Published: March 2021

Background: In our previous single-center study of autoimmune encephalitis (AE) related autoantibody test results we found positivity in 60 patients out of 1,034 with suspected AE from 2012 through 2018 as part of a Hungarian nationwide program. In our current multicenter retrospective study, we analyzed the clinical characteristics and outcome of AE patients with positive neuronal cell surface autoantibody test results.Methods: A standard online questionnaire was used to collect demographic and clinical characteristics, laboratory and imaging data, therapy and prognosis of 30 definitive AE patients in four major clinical centers of the region.Results: In our study, 19 patients were positive for anti-NMDAR (63%), 6 patients (20%) for anti-LGI1, 3 patients for anti-GABABR (10%) and 3 patients for anti-Caspr2 (10%) autoantibodies. Most common prodromal symptoms were fever or flu-like symptoms (10/30, 33%). Main clinical features included psychiatric symptoms (83%), epileptic seizures (73%) and memory loss (50%). 19 patients (63%) presented with signs of central nervous system (CNS) inflammation, which occurred more frequently in elder individuals (p = 0.024), although no significant differences were observed in sex, tumor association, time to diagnosis, prognosis and immunotherapy compared to AE patients without CNS inflammatory markers. Anti-NMDAR encephalitis patients were in more severe condition at the disease onset (p = 0.028), although no significant correlation between mRS score, age, sex and immunotherapy was found. 27% of patients (n = 8) with associated tumors had worse outcome (p = 0.045) than patients without tumor. In most cases, immunotherapy led to clinical improvement of AE patients (80%) who achieved a good outcome (mRS ≤ 2; median follow-up 33 months).Conclusion: Our study confirms previous publications describing characteristics of AE patients, however, differences were observed in anti-NMDAR encephalitis that showed no association with ovarian teratoma and occurred more frequently among young males. One-third of AE patients lacked signs of inflammation in both CSF and brain MRI, which emphasizes the importance of clinical symptoms and autoantibody testing in diagnostic workflow for early introduction of immunotherapy, which can lead to favorable outcome in AE patients.
Fish Protein Ingestion Induces Neural, but Not Muscular Adaptations, Following Resistance Training in Young Adults
Authors: Watanabe Kohei , Holobar Aleš , Uchida Kenji , Mita Yukiko 
Published: March 2021

Purpose: Nutritional supplementation in conjunction with exercise is of interest for the prevention or improvement of declines in motor performances in older adults. An understanding of the effects on both young and older adults contributes to its effective application. We investigated the effect of fish protein ingestion with resistance training on neural and muscular adaptations in young adults using interventions and assessments that have already been tested in older adults.Methods: Eighteen young adults underwent 8 weeks of isometric knee extension training. During the intervention, nine participants ingested 5 g of fish protein (n = 9, Alaska pollack protein, APP), and the other nine participants ingested casein as a control (n = 9, CAS) in addition to daily meals. Before, during, and after the intervention, the isometric knee extension force, lower extremity muscle mass, and motor unit firing pattern of knee extensor muscles were measured.Results: Maximum voluntary contraction (MVC) was significantly increased in both APP and CAS groups from 0 weeks to 4, 6, and 8 weeks of intervention (p &lt; 0.001), but there were no significant differences between the groups (p = 0.546–0.931). Muscle mass was not significantly changed during the intervention in either group (p = 0.250–0.698). Significant changes in motor unit firing rates (p = 0.02 and 0.029 for motor units recruited at 20–40% of MVC and at 40–60%) were observed following the intervention in the APP but not CAS (p = 0.120–0.751) group.Conclusions: These results suggest that dietary fish protein ingestion changes motor unit adaptations following resistance training in young adults.
Identification of Survival-Associated Gene Signature in Lung Cancer Coexisting With COPD
Authors: Miao Ti-wei , Du Long-yi , Xiao Wei , Mao Bing , Wang Yan , Fu Juan-juan 
Published: March 2021

Background: Chronic obstructive pulmonary disease (COPD) and lung cancer often coexist, which is associated with a worse prognosis. Thousands of biomarkers related to the survival of lung cancer have been investigated. However, those which can predict the survival of lung cancer coexisting with COPD are currently lacking. The present study aimed to identify novel gene signatures to predict the survival of patients with lung cancer coexisting COPD.Method: RNA-sequence data of lung cancer and control accompanying with matched clinical information were retrieved from the Cancer Genome Atlas (TCGA). Differently expressed genes (DEGs) associated with lung cancer coexisting COPD were screened. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were performed. Univariate and multivariate Cox regression analyses were applied to identify survival-associated DEGs and to construct survival-associated gene signature. Kaplan-Meier survival analysis and calibration plots of the nomogram were performed to test the predictive accuracy of the gene signature. qPCR was performed to validate the genes in the prognostic signature.Results: Sequence data from 70 patients with lung cancer coexisting COPD, 127 with lung cancer alone and 108 control tissues were included for analysis. A total of 2424 DEGs were identified when comparing lung cancer coexisting COPD with controls. The biological process was primarily associated with DNA-binding transcription activator activity, peptidase inhibitor activity, endopeptidase inhibitor activity, et al. KEGG pathways were mainly enriched in neuroactive ligand-receptor interaction, cell cycle, and Staphylococcus aureus infection. A survival-associated gene signature consisting of CEACAM5, RASAL1, CSTL1, CNGB1, and SLC4A3 was identified and represented as risk score. The high-risk score group had significantly worse survival than the low-risk score group (P &lt; 0.001). Areas under receiver operating characteristic curves were 0.943, 0.773, 0.888 for predicting overall survival at 1-, 3-, and 5-year, respectively. The risk score was an independent predictor of survival, independent of clinical factors. High conformity of the actual survival and the nomogram–predicted probability of survival by applying the risk score. Upregulation of the five genes in patients with lung cancer coexisting COPD were confirmed by qPCR in an independent cohort.Conclusion: Our study constructed and validated a novel prognostic gene signature for predicting survival of patient with lung cancer coexisting COPD, which may contribute to the clinical treatment decisions.
Glycogen Synthase Kinase-3 Beta Expression Correlates With Worse Overall Survival in Non-Small Cell Lung Cancer—A Clinicopathological Series
Authors: Alves Marclesson , Borges Daniela de Paula , Kimberly Aline , Martins Neto Francisco , Oliveira Ana Claudia , Sousa Juliana Cordeiro de , Nogueira Cleto D. , Carneiro Benedito A. , Tavora Fabio 
Published: March 2021

BackgroundGlycogen Synthase Kinase-3 beta (GSK-3β) regulates diverse cell functions including metabolic activity, signaling and structural proteins. GSK-3β phosphorylates target pro-oncogenes and regulates programmed cell death-ligand 1 (PD-L1). This study investigated the correlation between GSK-3β expression and clinically relevant molecular features of lung adenocarcinoma (PDL1 score, PTEN expression and driver mutations).MethodsWe evaluated 95 lung cancer specimens from biopsies and surgical resections. Immunohistochemistry was performed to analyze the expression of GSK-3β, PTEN, and PDL1. Epidemiological data, molecular characteristics and staging were evaluated from medical records. The histologic classification was performed by an experienced pulmonary pathologist.ResultsMost patients were female (52.6%) and the majority had a positive smoking history. The median age was 68.3 years, with individuals over 60 years accounting for 82.1%. The predominant histological subtype was adenocarcinoma (69.5%), followed by squamous cell carcinoma (20.0%). GSK-3β expression in tumors was cytoplasmic with a dotted pattern and perinuclear concentration, with associated membranous staining. Seven (7.3%) tumors had associated nuclear expression localization. Seventy-seven patients (81.1%) had advanced clinical-stage tumors. GSK-3β was positive in 75 tumors (78%) and GSK3-positive tumors tended to be diagnosed at advanced stages. Among stage III/IV tumors, 84% showed GSK3 positivity (p= 0.007). We identified a statistically significant association between GSK-3β and PTEN in the qualitative analysis (p 0.021); and when comparing PTEN to GSK-3β intensity 2+ (p 0.001) or 3+ expression (&gt; 50%) – p 0.013. GSK-3β positive tumors with a high histological score had a worse overall survival.ConclusionWe identified the histological patterns of GSK-3β expression and evaluated its potential as marker for overall survival, establishing a simple histological score to measure the evaluated status in resected tissues. The use of GSK-3β expression as an immune response biomarker remains a challenge. Future studies will seek to explain the role of its interaction with PTEN.
Prognostic Value of an Autophagy-Related Five-Gene Signature for Lower-Grade Glioma Patients
Authors: Guo Jin-Cheng , Wei Qing-Shuang , Dong Lei , Fang Shuang-Sang , Li Feng , Zhao Yi 
Published: March 2021

Background: Molecular characteristics can be good indicators of tumor prognosis and have been introduced into the classification of gliomas. The prognosis of patients with newly classified lower-grade gliomas (LGGs, including grade 2 and grade 3 gliomas) is highly heterogeneous, and new molecular markers are urgently needed.Methods: Autophagy related genes (ATGs) were obtained from Human Autophagy Database (HADb). From the Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA), gene expression profiles including ATG expression information and patient clinical data were downloaded. Cox regression analysis, receiver operating characteristic (ROC) analysis, Kaplan–Meier analysis, random survival forest algorithm (RSFVH) and stratification analysis were performed.Results: Through univariate Cox regression analysis, we found a total of 127 ATGs associated with the prognosis of LGG patients from TCGA dataset and a total of 131 survival-related ATGs from CGGA dataset. Using TCGA dataset as the training group (n = 524), we constructed a five-ATG signature (including BAG1, BID, MAP1LC3C, NRG3, PTK6), which could divide LGG patients into two risk groups with significantly different overall survival (Log Rank P &lt; 0.001). Then we confirmed in the independent CGGA dataset that the five-ATG signature had the ability to predict prognosis (n = 431, Log Rank P &lt; 0.001). We further discovered that the predictive ability of the five-ATG signature was better than the existing clinical indicators and IDH mutation status. In addition, the five-ATG signature could further classify patients after receiving radiotherapy or chemotherapy into groups with different prognosis.Conclusions: We identified a five-ATG signature that could be a reliable prognostic marker and might be therapeutic targets for autophagy therapy for LGG patients.