bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finding associations in a heterogeneous setting: statistical test for aberration enrichment
Authors: Mezlini Aziz M. , Das Sudeshna , Goldenberg Anna 
Published: April 2021

AbstractMost two-group statistical tests find broad patterns such as overall shifts in mean, median, or variance. These tests may not have enough power to detect effects in a small subset of samples, e.g., a drug that works well only on a few patients. We developed a novel statistical test targeting such effects relevant for clinical trials, biomarker discovery, feature selection, etc. We focused on finding meaningful associations in complex genetic diseases in gene expression, miRNA expression, and DNA methylation. Our test outperforms traditional statistical tests in simulated and experimental data and detects potentially disease-relevant genes with heterogeneous effects.
Application of systems biology-based in silico tools to optimize treatment strategy identification in Still’s disease
Authors: Segú-Vergés Cristina , Coma Mireia , Kessel Christoph , Smeets Serge , Foell Dirk , Aldea Anna 
Published: April 2021

Abstract
Background
Systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease (AOSD) are manifestations of an autoinflammatory disorder with complex pathophysiology and significant morbidity, together also termed Still’s disease. The objective of the current study is to set in silico models based on systems biology and investigate the optimal treat-to-target strategy for Still’s disease as a proof-of-concept of the modeling approach.

Methods
Molecular characteristics of Still’s disease and data on biological inhibitors of interleukin (IL)-1 (anakinra, canakinumab), IL-6 (tocilizumab, sarilumab), and glucocorticoids as well as conventional disease-modifying anti-rheumatic drugs (DMARDs, methotrexate) were used to construct in silico mechanisms of action (MoA) models by means of Therapeutic Performance Mapping System (TPMS) technology. TPMS combines artificial neuronal networks, sampling-based methods, and artificial intelligence. Model outcomes were validated with published expression data from sJIA patients.

Results
Biologicals demonstrated more pathophysiology-directed efficiency than non-biological drugs. IL-1 blockade mainly acts on proteins implicated in the innate immune system, while IL-6 signaling blockade has a weaker effect on innate immunity and rather affects adaptive immune mechanisms. The MoA models showed that in the autoinflammatory/systemic phases of Still’s disease, in which the innate immunity plays a pivotal role, the IL-1β-neutralizing antibody canakinumab is more efficient than the IL-6 receptor-inhibiting antibody tocilizumab. MoA models reproduced 67% of the information obtained from expression data.

Conclusions
Systems biology-based modeling supported the preferred use of biologics as an immunomodulatory treatment strategy for Still’s disease. Our results reinforce the role for IL-1 blockade on innate immunity regulation, which is critical in systemic autoinflammatory diseases. This further encourages early use on Still’s disease IL-1 blockade to prevent the development of disease or drug-related complications. Further analysis at the clinical level will validate the findings and help determining the timeframe of the window of opportunity for canakinumab treatment.
Helicobacter cinaedi bacteraemia secondary to enterocolitis in an immunocompetent patient
Authors: Rasmussen Sofie Larsen , Ørsted Iben , Tarpgaard Irene Harder , Nielsen Hans Linde 
Published: April 2021

AbstractBackgroundHelicobacter cinaediare motile, gram-negative spiral rods with a natural reservoir in the intestinal tract of hamsters and rhesus monkeys. In humans,H. cinaedihas been reported in different human infections like fever, abdominal pain, gastroenteritis, proctitis, diarrhoea, erysipelas, cellulitis, arthritis, and neonatal meningitis typically diagnosed by positive blood cultures. Even thoughH. cinaedihas been detected from human blood and stool the entry ofH. cinaediinto the blood stream was undocumented until quite recently. The use of pulse-field gel electrophoresis (PFGE) demonstrated that stool- and blood-derivedH. cinaedistrains were consistent.Case presentationHere, we describe a rare Danish case ofH. cinaedibacteraemia in an immunocompetent 44-year-old male with diarrhoea. We isolatedH. cinaedifrom a blood culture taken at admission, and from a FecalSwab taken at day six despite ongoing antibiotic therapy. Next, we made a genetic comparison of both isolates by use of Multi-locus sequence typing (MLST)- and Single nucleotide polymorphism (SNP)-analysis. The two isolates were identical with zero SNPs and by use of MLST the isolate was identified as a novel ST20, confirming previous data of the intestinal tract as a route ofH. cinaedibacteraemia. The results of our AST showed a resistance pattern with higher MICs for ciprofloxacin and clarithromycin than for ampicillin, amoxicillin, gentamicin, and imipenem. The patient was cured with targeted therapy with pivampicillin; however, the primary source of transmission was unknown.ConclusionsIn conclusion, this case ofH. cinaedibacteraemia secondary to enterocolitis in an immunocompetent patient provide clear evidence that one route of infection occurs through translocation from the intestinal tract to the bloodstream.Helicobacter cinaedifrom blood and faeces were identical with a novel ST20, resistant to ciprofloxacin and clarithromycin however, the patient was cured with oral pivampicillin.
Network slicing: a next generation 5G perspective
Authors: Subedi Prashant , Alsadoon Abeer , Prasad P. W. C. , Rehman Sabih , Giweli Nabil , Imran Muhammad , Arif Samrah 
Published: April 2021

AbstractFifth-generation (5G) wireless networks are projected to bring a major transformation to the current fourth-generation network to support the billions of devices that will be connected to the Internet. 5G networks will enable new and powerful capabilities to support high-speed data rates, better connectivity and system capacity that are critical in designing applications in virtual reality, augmented reality and mobile online gaming. The infrastructure of a network that can support stringent application requirements needs to be highly dynamic and flexible. Network slicing can provide these dynamic and flexible characteristics to a network architecture. Implementing network slicing in 5G requires domain modification of the preexisting network architecture. A network slicing architecture is proposed for an existing 5G network with the aim of enhancing network dynamics and flexibility to support modern network applications. To enable network slicing in a 5G network, we established the virtualisation of the underlying physical 5G infrastructure by utilising technological advancements, such as software-defined networking and network function virtualisation. These virtual networks can fulfil the requirement of multiple use cases as required by creating slices of these virtual networks. Thus, abstracting from the physical resources to create virtual networks and then applying network slicing on these virtual networks enable the 5G network to address the increased demands for high-speed communication.
An integrated scheduling algorithm for multi-device-processes with the strategy of exchanging adjacent parallel processes of the same device
Authors: Wang Zhen , Zhang Xiaohuan , Cao Yuxiao , Lai Guoming 
Published: April 2021

AbstractAt present, Multi-Devices-Process Integrated Scheduling Algorithm with Time-Selective Strategy for Process Sequence (MISATPS) is an advanced algorithm in the field of integrated scheduling with multi-devices-process problems. This algorithm ignores the influence of the pre-process on the post-process when solving the multi-devices-process integrated scheduling problem, which leads to the problem of poor closeness between serial processes and poor parallelism between parallel processes. This paper points out that there is no restriction of scheduling sequence between parallel processes on the same processing device. It can be scheduled flexibly of the sequence between parallel processes of the same device. Therefore, based on the scheduling scheme of MISATPS, the algorithm is improved by applying the interchange strategy and the interchange adjustment strategy of multi-device adjacent parallel process. In this way, the influence of the pre-process on the post-process is avoided, the compactness of the serial process and the parallelism of the parallel process are improved, and the scheduling result is optimized.
Intraoperative and postoperative outcomes of robot-assisted cholecystectomy: a systematic review
Authors: Shenoy Rivfka , Mederos Michael A. , Ye Linda , Mak Selene S. , Begashaw Meron M. , Booth Marika S. , Shekelle Paul G. , Wilson Mark , Gunnar William , Maggard-Gibbons Melinda , Girgis Mark D. 
Published: April 2021

Abstract
Background
Rapid adoption of robotic-assisted general surgery procedures, particularly for cholecystectomy, continues while questions remain about its benefits and utility. The objective of this study was to compare the clinical effectiveness of robot-assisted cholecystectomy for benign gallbladder disease as compared with the laparoscopic approach.

Methods
A literature search was performed from January 2010 to March 2020, and a narrative analysis was performed as studies were heterogeneous.

Results
Of 887 articles screened, 44 met the inclusion criteria (range 20–735,537 patients). Four were randomized controlled trials, and four used propensity-matching. There were variable comparisons between operative techniques with only 19 out of 44 studies comparing techniques using the same number of ports. Operating room time was longer for the robot-assisted technique in the majority of studies (range 11–55 min for 22 studies, p < 0.05; 15 studies showed no difference; two studies showed shorter laparoscopic times), while conversion rates and intraoperative complications were not different. No differences were detected for the length of stay, surgical site infection, or readmissions. Across studies comparing single-port robot-assisted to multi-port laparoscopic cholecystectomy, there was a higher rate of incisional hernia; however, no differences were noted when comparing single-port robot-assisted to single-port laparoscopic cholecystectomy.

Conclusions
Clinical outcomes were similar for benign, elective gallbladder disease for robot-assisted compared with laparoscopic cholecystectomy. Overall, the rates of complications were low. More high-quality studies are needed as the robot-assisted technique expands to more complex gallbladder disease, where its utility may prove increasingly beneficial.

Systematic review registration
PROSPERO CRD42020156945
New characterizations of weights on dynamic inequalities involving a Hardy operator
Authors: Saker S. H. , Alzabut J. , Saied A. I. , O’Regan D. 
Published: April 2021

AbstractIn this paper, we establish some new characterizations of weighted functions of dynamic inequalities containing a Hardy operator on time scales. These inequalities contain the characterization of Ariňo and Muckenhoupt when $\mathbb{T}=\mathbb{R}$
T
=
R
, whereas they contain the characterizations of Bennett–Erdmann and Gao when $\mathbb{T}=\mathbb{N}$
T
=
N
.
On superstability of exponential functional equations
Authors: Noori Batool , Moghimi M. B. , Najati Abbas , Park Choonkil , Lee Jung Rye 
Published: April 2021

AbstractThe aim of this paper is to prove the superstability of the following functional equations:
$$\begin{aligned}& f \bigl(P(x,y) \bigr)= g(x)h(y), \\& f(x+y)=g(x)h(y). \end{aligned}$$

f

(
P
(
x
,
y
)
)

=
g
(
x
)
h
(
y
)
,

f
(
x
+
y
)
=
g
(
x
)
h
(
y
)
.
Stability analysis of swarming model with time delays
Authors: Himakalasa Adsadang , Wongkaew Suttida 
Published: April 2021

AbstractA swarming model is a model that describes the behavior of the social aggregation of a large group of animals or the community of humans. In this work, the swarming model that includes the short-range repulsion and long-range attraction with the presence of time delay is investigated. Moreover, the convergence to a consensus representing dispersion and cohesion properties is proved by using the Lyapunov functional approach. Finally, numerical results are provided to demonstrate the effect of time delay on the motion of the group of agents.
Validation of the Arabic version of the “12-item short-form health survey” (SF-12) in a sample of Lebanese adults
Authors: Haddad Chadia , Sacre Hala , Obeid Sahar , Salameh Pascale , Hallit Souheil 
Published: April 2021

Abstract
Background
In clinical practice, quality of life measures can be used alongside some types of assessment to give valuable information that can identify areas that influence an individual and help the clinician make the best healthcare choices. This study aimed to investigate the psychometric properties of the Arabic version of the 12-item short-form health survey (SF-12) in a sample of Lebanese adults.

Methods
This cross-sectional study performed between July and November 2019 recruited 269 participants. Cronbach’s alpha was used to assess the reliability of the SF-12 questionnaire, and a factor analysis using the principal component analysis was performed to confirm its construct validity.

Results
The mean score for the “physical component summary (PCS-12)” was 50.27 ± 8.94 (95 % CI: 49.18–51.36) and for the “Mental component summary (MCS-12)” was 44.95 ± 12.17 (95 % CI: 43.47–46.43). A satisfactory Cronbach’s alpha was found for the two components: MCS (α = 0.707) and PCS (α = 0.743). The principal component analysis converged over a two-factor solution (physical and mental), explaining a total variance of 55.75 %. Correlations between the SF-12 scales and single items were significant, showing a good construct validity. The “physical functioning”, “role physical”, “bodily pain”, and “general health” subscales were highly associated with “PCS-12”, while the “vitality”, “social functioning”, “role emotional”, and “mental health” subscales were more associated with MCS-12.

Conclusions
The Arabic version of the SF-12 is a reliable, easy-to-use, and valid tool to measure health-related quality of life in the general population. Future studies using a larger sample size and focusing on questionnaire psychometric properties are necessary to confirm our findings.
Effect of low salicylate diet on clinical and inflammatory markers in patients with aspirin exacerbated respiratory disease – a randomized crossover trial
Authors: Sowerby Leigh J. , Patel Krupal B. , Schmerk Crystal , Rotenberg Brian W. , Rocha Taciano , Sommer Doron D. 
Published: April 2021

Background Aspirin-exacerbated respiratory disease (AERD) is characterized by eosinophilic rhinosinusitis, nasal polyposis, and bronchial asthma, along with the onset of respiratory reactions after the ingestion of nonsteroidal anti-inflammatory drugs (NSAIDs) or acetylsalicylic acid (ASA). In addition to the therapeutic routines and surgical options available, a low dietary intake of food salicylate has been suggested as adjunctive therapy for this condition. This study aimed to assess the influence of a short-term low salicylate diet on inflammatory markers in patients with AERD and whether that would result in symptomatic improvement. Methods Prospective study with randomization to either a high or low salicylate diet for 1 week, followed by cross-over to the other study arm. Participants were asked to record their dietary salicylate for each week of the study. Urinary creatinine, salicylate and leukotriene levels were measured at the time of recruitment, end of week one and end of week two and the SNOT-22 questionnaire was filled out at the same time points. Results A total of seven participants completed the study. There was no statistical difference in the urinary salicylate and leukotriene levels between the two diets; nevertheless, participants on low salicylate diet reported improved SNOT-22 symptoms scores ( p = 0.04), mainly in the rhinologic, ear/facial, and sleep dysfunction symptom domains. In addition, these last two domains outcomes were more significant than the minimal clinically important difference. Conclusions A short-term low salicylate diet may not result in biochemical outcomes changes but seems to provide significant symptomatic relief for patients with AERD. Trial registration NCT01778465 ( www.clinicaltrials.gov ) Graphical abstract
Application of modified green algae Nannochloropsis sp. as adsorbent in the simultaneous adsorption of Methylene Blue and Cu(II) cations in solution
Authors: Buhani  , Wijayanti Tri Agus , Suharso  , Sumadi  , Ansori Muslim 
Published: April 2021

AbstractBiomass of algae is a very potent adsorbent for absorbing aqueous waste containing heavy metals and organic dyes. This study purposes to confirm the ability of adsorbents from green algae Nannochloropsis sp. modified with silica (ASN) and followed by coating magnetite particles (ASN-MPs) to absorb simultaneously the mixture of Methylene Blue (ME) and Cu(II) cations in aqueous solution. Simultaneous sorption of ME and Cu(II) cations to ASN and ASN-MPs was carried out by the batch method with the interaction pH condition 7, contact time 90 min, and initial concentrations of ME and Cu(II) cations (0.1–1.0 mM). Based on adsorption data, Cu(II) cations have a greater adsorption rate and capacity (qm) compared to ME at the same contact time and initial concentration. The adsorption capacity (qm) values of the bi-component ME and Cu(II) cation mixture in ASN and ASN-MPs were 1.39 × 10− 1 and 5.32 × 10− 1 mmol g− 1, respectively, with the binary Langmuir adsorption isotherm constant for Cu(II) cations greater than ME. Modified adsorbent from algae Nannochloropsis sp. with silica matrix and magnetite particle coating is an adsorbent that has a high effectiveness in the collective sorption of ME and Cu(II) cations. Therefore, these adsorbents can be used for the adsorption of cation mixtures of heavy metals and organic dyes that are cationic in solution.
Icariin protects against cage layer osteoporosis by intervening in steroid biosynthesis and glycerophospholipid metabolism
Authors: Yu Zhengwang , Huang Jie , Zhou Zhongxin 
Published: April 2021

AbstractCage layer osteoporosis (CLO) is a common bone metabolism disease in the breeding industry of China. However, effective prevention for CLO has not been developed. Icariin (ICA), the main bioactive component of the Chinese herb Epimedium, has been shown to have good therapeutic effects on bone-related diseases. In this study, the effects of ICA were further evaluated in a low-calcium diet-induced CLO, and a serum metabolomics assay was performed to understand the underlying mechanisms. A total of 144 31-wk-old Lohmann pink-shell laying hens were randomly allocated to 4 groups with 6 replicates of 6 hens per replicate. The 4 dietary treatment groups consisted of a basal diet (3.5% calcium), a low-calcium diet (2.0% calcium), and a low-calcium diet supplemented with 0.5 or 2.0 g/kg ICA. The results showed that ICA exerted good osteoprotective effects on low-calcium diet-induced CLO. ICA significantly increased femur bone mineral density, improved bone microstructure, decreased bone metabolic level, and upregulated mRNA expression of bone formation genes in femoral bone tissue. Serum untargeted metabolomics analysis showed that 8 metabolite levels were significantly changed after ICA treatment, including increased contents of 7-dehydrocholesterol, 7-oxocholesterol, desmosterol, PC (18:1(9Z)/18:1(9Z)), PS (18:0/18:1(9Z)), N,N-dimethylaniline and 2-hydroxy-butanoic acid and decreased N2,N2-dimethylguanosine. Metabolic pathway analysis based on the above 8 metabolites indicated that ICA mainly perturbed steroid biosynthesis and glycerophospholipid metabolism. These findings suggest that ICA can effectively prevent bone loss in low-calcium diet-induced CLO by mediating steroid biosynthesis and glycerophospholipid metabolism and provide new information for the regulation of bone metabolic diseases.
Assessing recovery in treatment as usual provided by community child and adolescent mental health services
Authors: Gibbons Naomi , Harrison Emma , Stallard Paul 
Published: April 2021

Background
Despite the importance of routinely assessing the outcomes of everyday practice, few studies have reported outcome metrics for child and adolescent mental health services (CAMHS).

Aims
Our aim is to investigate reliable change and recovery rates for treatment as usual, provided by one community CAMHS over two time periods.

Method
We prospectively audited accepted consecutive referrals from November 2017 to January 2018, and April to September 2019. Cases with paired outcomes were identified, and reliable change and recovery rates were calculated.

Results
Baseline outcome data were obtained for 672 (78.2%) and 744 (77.5%) young people in 2018 and 2019, respectively. Of eligible participants, 174 (59.2%) and 155 (45.7%) completed at least one follow-up outcome measure in 2018 and 2019, respectively. Pre- and post-test scores on the Revised Child Anxiety and Depression Scale (RCADS) and Strengths and Difficulties Questionnaire (SDQ) showed a reduction in symptoms. Total RCADS scores showed 21–25% of participants reliably improved, with 44–49% showing reliable improvement on one or more subscale. On the SDQ, 11 (15.5%) and 19 (25.3%) participants reported reliable improvement on at least one subscale in 2018 and 2019, respectively. Reliable recovery rates ranged from 48 to 51% for youth-completed and 40 to 42% for parent-completed RCADS.

Conclusions
Half of young people receiving treatment as usual from CAMHS reliably improved on at least one routine outcome measure subscale, improvement rates comparable with adult psychological therapies services. Our findings indicate that reliable change and recovery on subscale rather than total scores may be a better indication of outcomes.