bluuebunny/crossref_metadata_2025_split huggingface dataset:
Culprit site extracellular DNA and microvascular obstruction in ST-elevation myocardial infarction
Authors: Mangold Andreas , Ondracek Anna S , Hofbauer Thomas M , Scherz Thomas , Artner Tyler , Panagiotides Noel , Beitzke Dietrich , Ruzicka Gerhard , Nistler Sonja , Wohlschläger-Krenn Evelyne , Winker Robert , Quehenberger Peter , Traxler-Weidenauer Denise , Spannbauer Andreas , Gyöngyösi Mariann , Testori Christoph , Lang Irene M 
Published: June 2021

Abstract

Aims
Extracellular chromatin and deoxyribonuclease (DNase) have been identified as important players of thrombosis, inflammation, and homeostasis in a murine model. We previously demonstrated that activated neutrophils release neutrophil extracellular traps (NETs) at the culprit site in ST-elevation myocardial infarction (STEMI), which significantly contribute to extracellular chromatin burden, and are associated with larger infarcts. To understand the correlation between neutrophil activation, extracellular chromatin, and infarct size (IS), we investigated these parameters in a porcine myocardial infarction model, and at different time points and sites in a prospective STEMI trial with cardiac magnetic resonance (CMR) endpoints.

Methods and results
In a prospective STEMI trial (NCT01777750), 101 STEMI patients were included and blood samples were obtained from first medical contact until 6 months after primary percutaneous coronary intervention (pPCI) including direct sampling from the culprit site. CMR was performed 4 ± 2 days and 6 months after pPCI. Neutrophil counts, markers of extracellular chromatin, and inflammation were measured. Double-stranded deoxyribonucleic acid (dsDNA), citrullinated histone 3, nucleosomes, myeloperoxidase, neutrophil elastase, and interleukin (IL)-6 were significantly increased, while DNase activity was significantly decreased at the culprit site in STEMI patients. High neutrophil counts and dsDNA levels at the culprit site correlated with high microvascular obstruction (MVO) and low ejection fraction (EF). High DNase activity at the culprit site correlated with low MVO and high EF. In correspondence, dsDNA correlated with IS in the porcine myocardial infarction model. In porcine infarcts, neutrophils and extracellular chromatin were detected in congested small arteries corresponding with MVO. Markers of neutrophil activation, extracellular chromatin, DNase activity and CMR measurements correlated with markers of systemic inflammation C-reactive protein and IL-6 in patients.

Conclusions
NETs and extracellular chromatin are important determinants of MVO in STEMI. Rapid degradation of extracellular chromatin by DNases appears to be crucial for microvascular patency and outcome.
Chromosome-Scale Genome Assembly of the Resurrection Plant Acanthochlamys bracteata (Velloziaceae)
Authors: Gao Zhi-Yuan , Li Zhang-Hai , Lin Dong-Liang , Jin Xiao-Hua 
Published: June 2021

Abstract
Acanthochlamys bracteata (Velloziaceae) is a resurrection plant with cold tolerance. Herein, a chromosome-level reference genome of A. bracteata based on Nanopore, Illumina, and Hi-C data is reported. The high-quality assembled genome was 197.97 Mb, with a scaffold N50 value of 8.64 Mb and a contig N50 value of 6.96 Mb. We annotated 23,509 protein-coding genes. Eight contracted gene families and three expanded gene families were detected. Repeat sequences accounted for approximately 28.63% of the genome. The LEA1 and Dehydrin gene families, which are involved in desiccation resistance, expanded in A. bracteata. We identified genes involved in chilling tolerance, COLD1.
Unmet Expectations About Work at Age 62 and Depressive Symptoms
Authors: Abrams Leah R , Clarke Philippa J , Mehta Neil K 
Published: June 2021

Abstract

Objectives
Exiting the labor force earlier or later than planned is common, with predictable economic consequences. However, the mental health ramifications of such off-time events are not known but are important to promoting well-being in retirement.

Methods
Using the Health and Retirement Study (1992–2016), we created 6 groups based on the alignment of expectations about full-time work at age 62 (reported at ages 51–61) with realized labor force status after reaching age 62 (N = 10,421). Negative binomial models estimated the adjusted association between unmet expectations about work and depressive symptoms.

Results
Unexpectedly not working was associated with higher depressive symptoms than working as expected after adjusting for sociodemographic, economic, and health factors at the time of expectations (incidence rate ratio = 1.35, 95% confidence interval: 1.17–1.56). Additionally, adjusting for health declines and marriage dissolution between expectations and age 62 partially attenuated the association, but unexpectedly not working remained significantly associated with a 1.16 increase in the incidence rate of depressive symptoms. Unexpectedly working at 62 was not associated with depressive symptoms. Race/ethnicity interacted with expectation alignment (F(15,42) = 2.44, p = .0118) in that Hispanic respondents experienced an increase in depressive symptoms when working after unmet and unsure expectations compared to met expectations, whereas White respondents did not.

Discussion
Unlike working longer than expected, unexpectedly not working at age 62 was associated with depressive symptoms, even after accounting for health declines. Public and employer policies should assist workers in remaining in the labor force as long as planned and offer mental health supports for unexpected work exits.
A Controlled Pilot Study of the Wish Outcome Obstacle Plan Strategy for Spouses of Persons With Early-Stage Dementia
Authors: Monin Joan K , Oettingen Gabriele , Laws Holly , David Daniel , DeMatteo Lyndsay , Marottoli Richard 
Published: June 2021

Abstract

Objectives
Behavioral interventions can reduce distress for couples coping with early-stage dementia. However, most interventions are limited in accessibility and fail to address individualized goals. This pilot study examined the dyadic effects on multiple indicators of well-being of the Wish Outcome Obstacle Plan (WOOP) intervention, which guides participants to use Mental Contrasting with Implementation Intentions to achieve attainable goals in their daily lives.

Methods
This randomized controlled trial included 45 older persons with early-stage dementia (PWD) and their spousal care partners (CPs: n = 90 individuals). CPs were assigned randomly to WOOP training immediately after baseline (WOOP) or after a 3-month follow-up interview (Control; CON). Both groups received a dementia care education booklet. WOOP CPs were instructed to practice WOOP at least once a day for 2 weeks. All CPs and PWDs completed home surveys (baseline, 2 weeks, and 3 months), measuring perceived stress, depressive symptoms, quality of life, and affect.

Results
Mixed-effects models showed significant intervention × time interaction effects with large effect sizes for CPs on three of the five outcomes over 3 months. Compared with CON, WOOP CPs had decreased perceived stress (δ = 1.71) and increased quality of life (δ = 1.55) and positive affect (δ = 2.30). WOOP PWD showed decreased perceived stress (δ = 0.87) and increased quality of life (δ = 1.26), but these effects were not statistically significant.

Discussion
WOOP is a promising, brief intervention to improve dementia CPs’ well-being that may also positively affect their partners with dementia.
A Single Method for 127 Recommended and Additional DUID Drugs in Blood and Urine by LC–MS-MS
Authors: Farley Megan , Tran Helena , Towler Steven , Gevorkyan Jirair , Pearring Sue , Rodda Luke N 
Published: June 2021

Abstract
Driving under the influence of drug (DUID) cases continue to challenge forensic toxicologists as both the volume and complexity of casework increases. Comprehensive DUID testing should also meet the drafted Academy Standards Board (ASB)/ American National Standard Institute (ANSI) standard and the National Safety Council’s Alcohol, Drugs and Impairment Division (NSC-ADID) recommendations. A simple method using protein precipitation followed by filtration extraction with an 8 minute run time by liquid chromatography–tandem mass spectrometry (LC–MS-MS) was developed, and a comprehensive ASB/ANSI validation was performed. Target drugs and metabolites were quantitatively assessed in blood and qualitatively assessed in urine. Included were 127 target analytes including cannabinoids (12), amphetamines (11), cocaine and metabolites (6), benzodiazepines (36), Z-drugs (5), opioids (27), anticonvulsants (3), first-generation antihistamines (6), muscle relaxants (2), dissociatives and hallucinogens (6), barbiturates (10), and miscellaneous substances (3). Limits of detection are appropriate for DUID and other forensic casework such as drug-facilitated crime (DFC) and postmortem investigations. To demonstrate applicability, 78 proficiency test blood and urine samples and 1,645 blood and urine samples from authentic cases samples demonstrated effective detection of target analytes in forensic casework. By increasing the analytical scope of multiple drug classes via a single method, this technique detects drugs that may have previously gone undetected, such as flualprazolam, etizolam, mitragynine, gamma-hydroxybutyric acid and psilocin and improves laboratory efficiency by reducing the number of tests required. The described method is, to the authors’ best knowledge, the only published single procedure to meet all drugs listed in the drafted ASB/ANSI standard and recommended Tier 1 and traditional drugs from Tier 2 for DUID screening, while also achieving many drug scope and sensitivity recommendations for DFC and postmortem testing.
The case of ‘A Rhino Horn’: case report and proposal for modification to the Hetsroni and Kelly classification
Authors: Marín-Pena Oliver , Ayeni Olufemi R , Tey-Pons Marc , Mas-Martinez Jesús , Dantas Pedro , Khanduja Vikas 
Published: June 2021

Abstract
Subspine impingement syndrome by definition involves a prominent antero-inferior iliac spine (AIIS) which can lead to impingement on the femoral neck thereby causing symptoms. We present the case of a 22-year-old semi-professional athlete who presented with a Type III AIIS morphology leading to subspine impingement syndrome and was managed via a mini open anterior approach. Radiological examination revealed a fairly prominent left AIIS resembling the ‘horn of a rhino’ extending to the trochanteric region anteriorly. A mini-anterior surgical approach was utilized for the resection of the ‘rhino horn’ and the rectus femoris was reattached. The patient remained asymptomatic at the one-year follow-up and had resumed weightlifting. Following this case, we propose a new classification of the type III AIIS morphology in view of the clinical presentation. The AIIS type III-Standard represents an extension from the acetabular rim to less than 1 cm (type III-S) and type III-Large, with an extension from the acetabular rim beyond 1 cm (type III-L). The type III-L will further be divided into two groups based on its relation to the ilium, type III-Lr (‘rib shape’) and type III-Lrh (‘rhino horn’).
Democratizing the Senate from Within
Authors: Gould Jonathan S , Shepsle Kenneth A , Stephenson Matthew C 
Published: June 2021

AbstractThis article proposes that the U.S. Senate adopt a “popular-majoritarian cloture rule,” under which a motion to close debate and proceed to a final vote would carry if but only if supported by a majority of Senators who collectively represent a larger share of the population than those Senators in opposition. This rule, which would be a constitutional exercise of the Senate’s power to set the rules of its proceedings, would make the body more democratic and more functional, and would be preferable both to the current filibuster rule and to simple majority rule.
Seasonal fires shape the germinable soil seed bank community in eastern Mediterranean woodlands
Authors: Manela Neta , Shemesh Hagai , Osem Yagil , Carmel Yohay , Soref Chanoch , Tsafrir Anat , Ovadia Ofer 
Published: June 2021

AbstractWe explored if and how seasonal fires interact with microhabitat type (i.e. under Pistacia shrub, under Cistus shrub or a canopy gap) to influence the composition of the germinable soil seed bank (GSSB) community in a typical eastern Mediterranean woodland. We conducted a field experiment, involving prescribed spring and autumn burns, and thereafter quantified the seed germination patterns using soil samples collected from both burned and adjacent unburned control plots. Soil temperature was significantly higher during autumn burns, while being more variable during spring burns. Fire caused overall reductions in GSSB density, richness and diversity. The reductions in GSSB richness and diversity were significantly stronger under Pistacia and Cistus shrubs located within plots subjected to autumn burns, and these patterns were mainly evident among annuals. GSSB density of dwarf shrubs was higher in samples collected from burned plots, and this pattern was more pronounced in samples collected under Pistacia and Cistus shrubs. Together with the appearance of unique species, seasonal fires led to significant changes in the composition of the GSSB community. Our results illustrate that seasonal fires interact with spatial heterogeneity to influence the composition of the GSSB community mostly via differential effects on the germination densities of annuals and dwarf shrubs. These findings imply that the increase in the frequency of seasonal fires, which has occurred in the eastern Mediterranean basin during the last few decades, may translate into a shift in eco-evolutionary selection pressures, operating on plants inhabiting this unique ecosystem.
Rumors, Pescado Podrido and Disinformation in Interwar Argentina
Authors: Ablard Jonathan D , Bohoslavsky Ernesto 
Published: June 2021

Abstract
This article identifies how and why Argentine political rumors were created, spread, and legitimized by government officials, military officers and the press in the interwar years. In that period, the practice of what we now call “fake news”—known as pescado podrido (rotten fish) in Argentina for it poisons the one who hears or repeats it—became more common and took on international proportions. In Argentina, a variety of forces drove the increase in disinformation, including political instability, the rising (and later the banning) of the majoritarian Radical Party, elite anxiety about the threat of communism, and a long-lasting nationalist fear about the integrity of borders. Authorities and right-wing politicians were inclined to see any anti-government actions as linked to international communism and, in some cases, imaginary Jewish conspiracies. The article offers two case studies: One refers to the anti-Radical Party rumors, especially those spread in the days immediately before and after the coup d’état in 1930; and the other to a more generalized atmosphere of anti-communist inspired rumors and fake news in the interwar period. This article is based on research in government archives and newspaper collections in Patagonian cities, Buenos Aires, and Washington, D.C. Argentine official sources included records from the Ministry of the Interior, the Gobernación del Neuquén, President Agustín P. Justo’s papers and recently declassified army and navy documents.
Homeowner preferences drive lawn care practices and species diversity patterns in new lawn floras
Authors: Fuentes Tracy L 
Published: June 2021

Abstract
Households intensively manage lawns to create uniformly green, low diversity plant communities. Because lawns occupy a large proportion of urban green space, they are a crucial case for understanding how people manipulate urban vegetation. In this study, I focused on 58 homeowners who purchased a newly constructed home and yard in the Seattle Metropolitan Statistical Area, USA, to see how preferences, lawn care regimes and new lawn floras develop within a multi-scalar urban environment. A typical homeowner watered 3 times in spring, watered 24 times in summer, applied fertilizer twice, mowed 21 times and edged 15 times. Most new lawn turfgrasses were Lolium perenne, Poa pratensis and/or Festuca spp. Mean species richness was 6.5 ± 5.3 species. The most frequent species were non-native and cosmopolitan (turfgrasses, Hypochaeris radicata, Taraxacum officinale and Trifolium repens). Five variables increased the probability of homeowners managing their lawns as turfgrass monocultures: living in a neighborhood with larger yards, summer watering frequency, fertilizer frequency, valuing space for children and valuing wildlife habitat. Valuing an easy to manage yard decreased the turfgrass monoculture probability. In polyculture yards, having a larger lawn was positively correlated with non-turfgrass species richness, but elevation was negatively correlated. Homeowners who valued space for children appeared to have more intensive lawn care regimes than those who valued wildlife habitat or easy to manage yards. Although lawn floras result from complex interactions of the environment and households, urban characteristics appeared to be weaker drivers of diversity than homeowner preferences and lawn care.
The Discourse on Customary International Law
Authors: d'Aspremont Jean 
Published: June 2021

Abstract
This book argues that it does not suffice to simply invoke and demonstrate the two constitutive elements of customary international law, practice and opinion juris, to successfully and plausibly make a claim under the doctrine of customary international law. Behind what may look like a very crude dualist type of legal reasoning, a fine variety of discursive constructions are at work. By unpacking these discursive constructions, the book depicts the discursive splendour of customary international law. It reviews eight discursive performances at work in the discourse on customary international law and makes a number of original and provocative claims about this aspect of law. For example, the book claims that customary international law is not the surviving trace of an ancient law-making mechanism that used to be found in traditional societies. Indeed, as is shown throughout, the splendour of customary international law is everything but ancient. In fact, there is hardly any doctrine of international law that contains so many of the features of modern thinking. The book also puts forward the idea that all discursive performances of customary international law are shaped by texts, are articulated around texts, echo and continue pre-existing texts, unfold in a textual space, or, more simply, originate in a text-constituted environment.
The Enabling Constraint
Authors: d'Aspremont Jean 
Published: June 2021

Abstract
This chapter recounts the rise, consolidation, and fluctuation of the enabling constraint of the discourse on customary international law. It sets the stage for the discussion of the discursive performances that enabling constraint has prompted in international legal thought and practice. It also talks about the distinction between the two elements of customary international law: practice and opinio juris, which corresponds to a form of dualist thinking that came to thrive with modernity. The chapter describes dualist thinking about customary international law as a constraint that was formalized in the middle of the 20th century and that does not necessarily correspond to any ancient mode of thinking about customary international law. It shows that the dualist approach to the identification of customary international law has undergone a few variations over the last hundred years but uncontested in international legal thought and practice.
The Practicians
Authors: d'Aspremont Jean 
Published: June 2021

Abstract
This chapter reviews the dominant approach in which customary international law gets in validity, its legality, its consistency, and its factuality from practice and opinio juris. It investigates the presumptive character of the moment where practice and opinio juris coalesce and generate customary international law, which must be ascribed a genitor. It also emphasizes that as long as practice and opinio juris have a sufficient number of genitors, they can be conducive to the formation of customary international law. The chapter talks about practicians as the genitors of the practice which customary international law must emanate from, such as those that produce the actual behaviours (practice sensu stricto) and the beliefs (opinio juris) that are generative of customary international law. It outlines the determination of the practicians of customary international law as a discursive performance that is commonly and repeatedly witnessed in debates about customary international law.
Singling out modified gravity parameters and data sets reveals a dichotomy between Planck and lensing
Authors: Garcia-Quintero Cristhian , Ishak Mustapha 
Published: June 2021

ABSTRACT
An important route to testing general relativity (GR) at cosmological scales is usually done by constraining modified gravity (MG) parameters added to the Einstein perturbed equations. Most studies have analysed so far constraints on pairs of MG parameters, but here, we explore constraints on one parameter at a time while fixing the other at its GR value. This allows us to analyse various models while benefiting from a stronger constraining power from the data. We also explore which specific data sets are in tension with GR. We find that models with (μ = 1, η) and (μ, η = 1) exhibit a 3.9σ and 3.8σ departure from GR when using Planck18 + Supernovae type Ia (SNe) + Baryon acoustic oscillation (BAO), while (μ, η) shows a tension of 3.4σ. We find no tension with GR for models with the MG parameter Σ fixed to its GR value. Using a Bayesian model selection analysis, we find that some one-parameter MG models are moderately favoured over ΛCDM when using all data set combinations except Planck cosmic microwave background lensing and dark energy survey data. Namely, Planck18 shows a moderate tension with GR that only increases when adding any combination of redshift space distortion, SNe, or BAO. However, adding lensing diminishes or removes these tensions, which can be attributed to the ability of lensing in constraining the MG parameter Σ. The two overall groups of data sets are found to have a dichotomy when performing consistency tests with GR, which may be due to systematic effects, lack of constraining power, or modelling. These findings warrant further investigation using more precise data from ongoing and future surveys.
Secular resonance of inner test particles in hierarchical planetary systems
Authors: Lei Hanlun 
Published: June 2021

ABSTRACT
This work studies the secular resonance associated with the critical argument σ = ϖ (ϖ is the longitude of pericentre) for inner test particles moving in low-eccentricity region with inclination i smaller than 39°. To formulate the dynamical model, the double-averaged Hamiltonian is formulated up to an arbitrary order in the semimajor axial ratio, and then those high-order periodic terms are removed from the double-averaged Hamiltonian by means of Hori–Deprit transformation technique. The resulting Hamiltonian determines a resonant model with a single degree of freedom. Based on the resonant model, it becomes possible to explore the phase-space structure, resonant centre, and resonant width in an analytical manner. In particular, an excellent correspondence is found between the resonant width in terms of the eccentricity variation and the maximum variation of eccentricity (Δe) for test particles initially placed on quasi-circular orbits. It means that the secular dynamics in the low-eccentricity space with i &lt; 39° is dominantly governed by the secular resonance associated with σ = ϖ.