bluuebunny/crossref_metadata_2025_split huggingface dataset:
Box-Behnken Design Optimized TPGS Coated Bovine Serum Albumin Nanoparticles Loaded with Anastrozole
Authors: Kumar Ashish , Singh Ajit , Flora S.J.S. , Shukla Rahul 
Published: February 2021

Purpose:
In this study, a novel D-α-tocopheryl polyethylene glycol succinate (TPGS)
modified bovine serum albumin (BSA) nanoparticles (NPs) were developed for delivery of Anastrozole
(ANZ) which is optimized by Box-Behnken design (BBD). Fabricated TPGS-ANZ-BSA NPs
were evaluated for their physicochemical and drug release characteristics.

Methods:
TPGS-ANZ-BSA NPs were prepared by desolvation thermal gelation method and the effects
of critical process parameter (CPP) which are BSA amount, TPGS concentration and stirring
speed on the critical quality attributes (CQA) such as % drug loading (%DL) and particle size were
studied using BBD. TPGS-ANZ-BSA NPs were characterized using different spectroscopic techniques
including UV-Visible and FTIR is used to confirm the entrapment of ANZ in BSA. DSC
and PXRD revealed the amorphization of ANZ in the TPGS-ANZ-BSA NPs after freeze drying.
Scanning electron microscopy (SEM) analysis was performed for the surface morphology analyses
NPs. In vitro release studies were performed at pH 5.5 and pH 7.4 for 48h to mimic tumour microenvironment.

Results:
The BBD optimized TPGS-ANZ-BSA NPs showed 107 nm particle size with %DL 8.5±
0.5%. The spectroscopic and thermal characterizations revealed the successful encapsulation of
ANZ inside the NPs. The TPGS-ANZ-BSA NPs were found to exhibit burst release at pH 5.5 and
sustained release at pH 7.4. The short-term stability displayed no significant changes in physical
properties TPGS-ANZ-BSA NPs at room temperature for a period one month.

Conclusion:
The BBD optimized TPGS-ANZ-BSA nanoparticles showed enhanced physiochemical
properties for ANZ and potential candidates for anticancer agent drugs delivery.
Simple Way for Ag-NPs Preparation based on Starch Macromolecule
Authors: Fahmy H.M. , Aly A.A. , Abou-Okeil A. 
Published: February 2021

:Finding a sustainable, inexpensive way for Ag-NPs synthesis is considered as one of the most important requirements for industrial application. Oxidized starch was prepared using sodium periodate. Oxidized starch (DAS) was characterized by measuring aldehyde content and using FTIR spectroscopy. DAS was used as reducing and stabilizing agent for the preparation of Ag nanoparticles (Ag-NPs). Factors that may affect the preparation of Ag-NPs include pH, AgNO3/DAS molar ratio, temperature and time were studied. UV-Vis. spectroscopy and particle size analysis showed that DAS can act as reducing and stabilizing agent for the preparation of Ag-NPs and the mean particle size was 19 nm. The so prepared AgNPs were used as antibacterial agent for cotton fabric using the pad dry cure method. The results of antibacterial test showed that the presence of Ag-NPs enhanced the antibacterial properties of the treated cotton fabrics.
Novel Applications for Invasive and Non-invasive Tools in the Era of Contemporary
Percutaneous Coronary Revascularisation
Authors: Alkhalil Mohammad 
Published: February 2021

:
Percutaneous coronary intervention (PCI) is an expanding treatment option for patients with coronary artery disease (CAD). It is considered the default strategy for unstable presentation of CAD. PCI techniques have evolved over the last 4 decades with significant improvements in stent design, increase in functional assessment of coronary lesions, and the use of intra-vascular imaging. Nonetheless, the morbidity and mortality related to CAD remain significant. Advances in technology have allowed better understanding of the nature andprogression of CAD. New tools are now available that reflect the pathophysiological changes at the level of the myocardium and coronary atherosclerotic plaque. Certain changes within the plaque would render it more prone to rupture leading to acute vascular events. These changes are potentially detected using novel tools invasively, such near infra-red spectroscopy, or non-invasively using T2 mapping cardiovascular magnetic resonance imaging (CMR)and18F-Sodium Fluoride positron emission tomography/computed tomography. Similarly, changes at the level of the injured myocardium are feasibly assessed invasively using index microcirculatory resistance or non-invasively using T1 mapping CMR. Importantly, these changes could be detected immediately with the opportunity to tailor treatment to those considered at high risk. Concurrently, novel therapeutic options have demonstrated promising results in reducingfuture cardiovascular risks in patients with CAD. This Review article will discuss the role of these novel tools and their applicability in employing mechanical and pharmacological treatment to mitigate cardiovascular risk in patients with CAD.
Beta-Caryophyllene, a CB2R Selective Agonist, Protects Against Cognitive Impairment Caused by Neuro-inflammation and Not in Dementia Due to Ageing Induced by Mitochondrial Dysfunction
Authors: Kanojia Urja , Chaturbhuj Shrikant Gyaneshwar , Sankhe Runali , Das Maushami , Surubhotla Raviteja , Krishnadas Nandakumar , Gourishetti Karthik , Nayak Pawan Ganesh , Kishore Anoop 
Published: February 2021

Background:
Dementia is a neurodegenerative disorder majorly evidenced by cognitive
impairment. Although there are many types of dementia, the common underlying etiological factors
in all the types are neuro-inflammation or aging induced apoptosis. β-caryophyllene, a cannabinoid
type-2 receptor agonist, has been reported to have promising neuroprotective effects in cerebral
ischemia and neuro-inflammation.

Objective:
In the present study, we evaluated the effects of β-caryophyllene against animal models
of dementia whose etiology mimicked neuro-inflammation and aging.

Methods:
Two doses (50 and 100 mg/kg of body weight) of β-caryophyllene given orally were tested
against AlCl3-induced dementia in male Sprague Dawley (SD) rats using the Morris water maze
test. Subsequently, the effect of the drug was assessed for episodic memory in female SD rats using
novel object recognition task in doxorubicin-induced neuro-inflammation and chemobrain model.
Moreover, its effects were evaluated in D-galactose-induced mitochondrial dysfunction leading to
dementia.

Results:
β-caryophyllene, at both doses, showed significant improvement in memory when assessed
using parameters like target quadrant entries, escape latency and path efficiency in the Morris
water maze test for spatial memory. In the doxorubicin-induced chemobrain model, β-caryophyllene
at 100 mg/kg significantly elevated acetylcholinesterase and catalase levels and lowered lipid
peroxidation compared to the disease control. In the novel object recognition task, β-caryophyllene
at 100 mg/kg significantly improved recognition index and discrimination index in the treated animals
compared to the disease control, with a significant increase in catalase and a decrease in lipid
peroxidation in both hippocampus and frontal cortex. However, in the D-galactose-induced mitochondrial
dysfunction model, β-caryophyllene failed to show positive effects when spatial memory
was assessed. It also failed to improve D-galactose-induced diminished mitochondrial complex I
and II activities.

Conclusion:
Hence, we conclude that β-caryophyllene at 100 mg/kg protects against dementia induced
by neuro-inflammation with no effect on neuronal aging induced by mitochondrial dysfunction.
REFORMULATING THE APPLICABLE STRATEGIES IN IMPROVING FINANCIAL LITERACY AND INCLUSION INDEX TOWARD ISLAMIC CAPITAL MARKET
Authors: Syafril Syafwendi 
Published: February 2021

Indonesia’s financial inclusion and literacy index level in the Islamic capital market sector is quietly low at around 0.02% and 0.01%. Though Indonesia is known as a country with the largest Muslim population in the world with more than 85%. Furthermore, the fact of Indonesia is the 4th highest growth country in the capital market industry in Asia-Pacific throughout 2017. The potential for growth and development of the Islamic capital market in Indonesia is very high, but this fact is not followed by the growth rate of financial literacy and inclusion index especially in the capital market sector. The aim of this paper is to identify the new applicable strategic approach to improve Islamic financial literacy and inclusion in term of Islamic capital market sector. This research uses qualitative methods with a literature review from the article journal, government report, news report, and others in reviewing, identifying, and knowing the strategies that will be implemented. The results show there are six specific strategies used in improving Islamic capital market literacy and inclusion indexes namely, rebranding investment negative stereotype, building a sustainable promotion and campaign through offline and online platform, creating an online integrated marketplace for Islamic capital market products, improving corporate Sukuk and introducing a new SRI Sukuk product, forming agents & groups of Islamic capital market lovers, and monitoring & evaluating the applied strategy.
Perlindungan Hukum Terhadap Nasabah Mobile Banking dalam Transaksi Perbankan
Authors: Trisna Dewi Ni Made 
Published: February 2021

This essay discusses the legal protection for mobile banking custumers, because the mobile banking product as one of the delivery many benefits but contain many risk on the other side that could cause losses for the custumers. Therefore, the protection for mobile banking custumers is requiered in order to protect the rights of the custumers banking servise. The study was conducted to determine how the indonesian low and regulations that protect mobile banking custumers in banking transaction in case of the error transaction electronic in review of low number 11 of 2008 on information and electronic transactionsas well as the bank’s responsibility for the mobile banking custumers in case of a transaction error. This study is a normative study with the literature research method to analyze the book of legal literature and the low number 8 of 1999 about the custumers protection, low number 10 of 1998 about the indonesia banking sistem, low number 11 of 2008 about the transaction and electronic information. The result showed that although there is no customers legislation that specificaly regulates mobile banking, but in indonesia positive legal order there are laws and regulation which has provided legal protection for mobile banking custumers. There are law number 11 of 2008 about information and electronic transaction as contained in article 1.2 and 3. The bank’s responsibility to the custumer in case of error transaction. The loss is a proxy of fullfillment of one custumers protection law. Right to copensation in accordance with the treaty law in article 1313 civil law. Then the current legislation already includes aspects of legal protection for mobile banking custumers.
GAYA BAHASA DALAM CERITA PENDEK “AKU ADA” KARYA DEWI LESTARI: TINJAUAN STILISTIKA
Authors: UTAMI WIWIK SURYA 
Published: February 2021

Penelitian ini bertujuan untuk mendeskripsikan bentuk-bentuk gaya bahasa yang terdapat dalam cerita pendek “Aku ada” karya Dewi Lestari dengan menggunakan tinjauan stilistika. Penelitian ini menggunakan metode deskriptif kualitatif serta pengumpulan datanya menggunakan metode simak dan pendekatan stilistika. Hasil analisis data menunjukkan bahwa terdapat 2 gaya bahasa yang digunakan dalam cerpen “Aku Ada” yaitu 1. Gaya bahasa perbandingan ada 6 jenis gaya bahasa perbandingan yaitu simile, hiperbola, personifikasi, depersonifikasi,metafora, antropomorfisme. Yang paling dominan dalam gaya bahasa perbandingan adalah simile terdapat 9 buah ungkapan yang digunakan, hiperbola terdapat 3 buah, personifikasi dan depersonifikasi terdapat 2 buah, yang terakhir pada gaya bahasa perbandingan metafora terdapat 1 buah. 2. Gaya bahasa penegasan ada 3 jenis yaitu paralelisme, retoris dan klimaks. Yang paling dominan pada gaya bahasa penegasan adalah paralelisme yang terdiri dari 6 buah, retoris terdiri dari 4 buah, dan klimaks terdiri dari satu buah. Kata kunci: stilistika, gaya bahasa, novel
ATIKAN UNPAD: UPAYA PENINGKATAN PARTISIPASI DAN PENYELESAIAN SEKOLAH TINGKAT DASAR DAN MENENGAH DI PEDESAAN JAWA BARAT
Authors: - D. Chaerani , - Kurnia, D , - Darmayanti, N. 
Published: February 2021

Masyarakat (PPM) Prioritas Universitas Padjadjaran 2014 ini, berbagai kegiatan telah dilakukan dalamrangka mewujudkan capaian kegiatan dalam hal upaya peningkatan partisipasi dan penyelesaian sekolahtingkat dasar dan tingkat menengah di pedesaan Jawa Barat. Dalam hal ini yang menjadi perhatian kamiadalah apa yang dapat dilakukan tim PPM Prioritas Atikan Unpad untuk membantu Unit PelaksanaanTeknis Daerah untuk TK/SD dan Pendidikan Non Formal dalam hal menangani masyarakat putussekolah dan anak-anak usia pra sekolah dasar di pedesaan Jawa Barat. Target masyarakat yangmenjadi sasaran kegiatan kami adalah Pusat Kegiatan Belajar Masyarakat (PKBM), Kelompok Belajar,Pendidikan Usia Dini dan Taman Kanak-kanak/ Raudhatul Athfal. Lokasi PPM yang kami pilih adalahDesa Jatimukti Kecamatan Jatinangor Kabupaten Sumedang. Pelatihan Learning Skills diberikan untukmeningkatkan kemampuan para tutor dan guru dalam mengelola diri serta warga belajar didikannya.Secara umum, hasil dari kegiatan ini menunjukkan peningkatan antusiasme belajar dari warga belajar,tutor, pengelola PKBM serta para guru TK/PAUD.Diharapkan kegiatan ini dapat meningkatkan angka partisipasi dan penyelesaian sekolah tingkat dasar danmenengah.Kata Kunci: atikan unpad, angka partisipasi kasar, putus sekolah, kejar paket, PKBM,
UPAYA PENINGKATAN KUALITAS TANAH DI DESA SUKAMANAH DAN DESA NANGGERANG KECAMATAN CIGALONTANG KABUPATEN TASIKMALAYA JAWA BARAT MELALUI SOSIALISASI PUPUK HAYATI, PUPUK ORGANIK DAN OLAH TANAH KONSERVASI
Authors: Herdiyantoro Dian 
Published: February 2021

Pemakaian pupuk anorganik dalam jumlah berlebihan dan pengolahan tanah secara intensif dapat merusakkualitas tanah. Alternatif yang dapat digunakan untuk mengurangi dampak penggunaan pupuk anorganik danpengolahan tanah intensif adalah dengan pupuk hayati dan pupuk organik serta olah tanah konservasi. Tujuandari kegiatan KKNM-PPMD Integratif dengan judul Upaya Peningkatan Kualitas Tanah di Desa Sukamanahdan Desa Nanggerang Kecamatan Cigalontang Kabupaten Tasikmalaya Jawa Barat Melalui SosialisasiPupuk Hayati, Pupuk Organik dan Olah Tanah Konservasi adalah meningkatkan pengetahuanmasyarakat tentang manfaat penggunaan pupuk hayati dan pupuk organik serta pentingnya penerapan olahtanah konservasi untuk menjaga kelestarian tanah. Kegiatan KKNM-PPMD Integratif dilaksanakan daritanggal 7 Januari 2014 sampai dengan tanggal 6 Februari 2014. Pengenalan pupuk hayati, pupuk organik danolah tanah konservasi dilakukan melalui pertemuan dan diskusi dengan masyarakat Desa Sukamanah dan DesaNanggerang serta demonstrasi plot pembuatan kompos dari jerami padi. Peningkatan pengetahuan masyarakatdianalisis berdasarkan hasil ujian sebelum mengikuti kegiatan pre test dan setelah mengikuti kegiatan posttest. Data dianalisis menggunakan Uji t Dua Sampel Berpasangan (Paired Sample t Test) pada taraf 5%. Hasilkegiatan menunjukkan bahwa terjadi peningkatan pengetahuan masyarakat secara nyata khususnyapetani di Desa Sukamanah tentang pupuk hayati, pupuk organik dan olah tanah konservasi.
PENDAMPINGAN HUKUM UNTUK MENINGKATKAN KETERAMPILAN MASYARAKAT DALAM PEMBUATAN PERJANJIAN UNTUK MENUNJANG KEGIATAN USAHA DI DESA GEMPOL DAN RANCADAKA KECAMATAN PUSAKANAGARA KABUPATEN SUBANG
Authors: Zamil Yusuf Saiful 
Published: February 2021

Berdasarkan hasil survey ke lapangan, sebagian besar mata pencaharian masyarakat Desa Gempol danRancadaka Kecamatan Pusakanagara Kabupaten Subang adalah sebagai petani sawah dan petanipenghasil buah-buahan terutama buah mangga. Desa Rancadaka bahkan sebagai salah satu desa penghasilpadi terbesar di Kabupaten Subang, sedangkan desa Gempol merupakan desa dengan penghasil buahmangga terbesar di Kabupaten Subang. Oleh karena potensi pertanian yang cukup besar tersebut harusditopang dengan keahlian masyarakat dalam membuat perjanjian tertulis agar lebih menjamin kepastianhukum usaha masyarakat yang tujuan akhirnya dapat meningkatkan kesejahteraan masyarakat.Pendampingan Hukum Untuk Meningkatkan Keterampilan Masyarakat Dalam Pembuatan PerjanjianUntuk Menunjang Kegiatan Usaha Di Desa Gempol Dan Rancadaka Kecamatan Pusakanagara KabupatenSubang dilakukan pada Hari Kamis Tanggal 03 Juli 2014 di Sekolah Dasar Negeri Desa Gempol. Pendampinganhukum dihadiri oleh sekitar 50 (lima puluh) orang, pendampingan hukum ini sangat penting dilakukanuntuk memberikan keterampilan kepada masyarakat bagaimana caranya membuat perjanjian tertulis.Pada saat dilakukan pendampingan hukum, hampir sebagian besar masyarakat Desa Gempol danRancadaka, Kecamatan Pusakanagara, Kabupaten Subang tidak menggunakan perjanjian tertulis dalammelakukan transaksi jual beli, sewa menyewa dan transaksi-transaksi lainnya. Setelah dilakukan pendampinganhukum masyarakat menjadi sadar akan pentinganya menggunakan perjanjian tertulis untukmemberikan kepastian hukum terhadap aktivitas usahanya. Setelah dilakukan pendampingan hukummasyarakat Desa Gempol dan Rancadaka Kecamatan Pusakanagara, Kabupaten Subang menjadi terampildan sekurang-kurangnya mempunyai gambaran bagaimana membuat perjanjian tertulis, karena dalampendampingan hukum diberikan pelatihan langsung bagaimana praktek dan tahapan dalam pembuatanperjanjian tertulis mulai dari kepala perjanjian, para pihak dalam perjanjian, maksud dan tujuan dibuatnyaperjanjian, sampai kepada pasal-pasal yang harus ada dalam perjanjian dan penutup dari suatu perjanjian.
PEMBUATAN BERGER FEED UNTUK PAKAN SAPI PEDAGING, PEMANFAATAN KOTORAN UNTUK BIO GAS DAN PUPUK ORGANIK DI DESA SUKAMULYA DAN DESA KUDANGWANGI, KECAMATAN UJUNG JAYA, KABUPATEN SUMEDANG
Authors: Setiyatwan Hendi 
Published: February 2021

Kecamatan Ujung Jaya merupakan salah satu kecamatan yang terletak di sebelah utara Kabupaten Sumedang.Desa Sukamulya dan Desa Kudangwangi merupakan desa berbasis pertanian. Iklim di kedua wilayah tersebutadalah iklim tropis dengan curah hujan rata-rata 2.550 mm per tahun, suhu udara berkisar antara 18-33o C dengankelembaban 50-70%. Wilayah tersebut merupakan salah satu wilayah yang potensial untuk pengembanganternak sapi pedaging. Ketersediaan hijauan pakan ternak dan limbah pertanian cukup potensial untuk dijadikanpakan sapi pedaging. Berdasarkan hal demikian perlu dilakukan penyuluhan mengenai pembuatan bergerfeed untuk pakan sapi pedaging, pemanfaatan kotoran untuk biogas dan pupuk organik di Desa Sukamulya danDesa Kudangwangi Kecamatan Ujungjaya Kabupaten Sumedang. Pengabdian Kepada Masyarakat telahdilaksanakan selama empat bulan mulai bulan Januari sampai dengan April 2014. Serangkaian program telahdilaksanakan mulai dari pengenalan bahan pakan lokal, pembuatan berger feed, membuat bio gas, dan pembuatanpupuk organik. Penyuluhan dilakukan di Desa Sukamulya dan Desa Kudangwangi. Hasil kegiatan disimpulkanbahwa secara umum masyarakat Desa Sukamulya dan Desa Kudangwangi lebih antusias dalam mengikutiprogram penyuluhan dengan metode pendampingan langsung di lokasi, hal demikian tercermin dari aktifitaspeserta yang lebih responsip dan terarah.
LITERASI MEDIA BAGI GURU PAUD DI KECAMATAN CICALENGKA
Authors: Saepudin Encang , Agustini Damayani Ninis , Sukaesih - 
Published: February 2021

ABSTRAKPengabdian Kepada Masyarakat 2016 ini berjudul Pelatihan Literasi Informasi Media Pembelajaran Bagi Guru PAUD di Kecamatan Tanjungsari. Kegiatan Pelatihan literasi media ini bertujuan untuk menambah wawasan dan memberikan pengetahuan terbaru tentang pemanfaatan media sebagai sumber belajar bagi para guru dan siswa, terutama bagi guru yang harus membuat sebuah kegiatan pengajaran kepada siswanya. Kegiatan Pengabdian Kepada Masyarakat dilaksanakan bekerja sama dengan Pihak UPTD Dinas Pendidikan Kecamatan Cicalengka Kabupaten Bandung. Pelaksanaan Kegiatan Pengabdian Kepada Masyarakat yaitu pada tanggal 1 September 2016. Materi utama yang disampaikan dalam pelatihan ini yakni literasi media dan langkah-langkah membangun literasi media. Metode yang digunakan adalah ceramah, diskusi, dan simulasi. Hasil yang dicapai menujukan adanya peningkatan pengetahuan dan keterampilan dari seluruh peserta.Hal ini terlihat dari hasil pretest dan posttest yang dilaksanakan.Jumlah peserta mencapai target, dengan animo peserta cukup tinggi menghasilkan diskusi mengalir dan simulasi dilaksanakan dengan sangat antusias. Dari hasil refleksi kegiatan, diperoleh kesimpulan bahwa peserta memahami dan mampu membuat rancangan pembelajaran berbasis literasi media. ABSTRACT This 2016 Community Services is entitled Learning Media Information Literacy Training for Teachers of PAUD in District Cicalengka. Media literacy training activities aim to broaden and provide the latest knowledge about the use of media as a source of learning for teachers and students, especially for teachers who have to make teachingactivities for their students. The community service activities were carried out in collaboration with the UPTD (Department of Education of Subdistrict) Bandung District of Cicalengka. The Community Services Activity was conducted on 1 September 2016. The main materials presented were the media literacy training and steps to build media literacy. The methods used were lectures, discussions, and simulation. The result showed an increase in knowledge and skills of all participants. This was shown from the results of pretest and posttest conducted. The number of participants achieving the target, with the participants' high interest had generated discussion flowed, and simulations were carried out with great enthusiasm. From the results of activities reflection, it was concluded that participants understood and were able to create media literacy based learning design.
C2 quad-screws facilitate 4-rod fixation across the cervico-thoracic junction
Authors: Cady-McCrea Clarke I. , Galgano Michael A. 
Published: February 2021

Background:
Cervical spine deformity is a potentially devitalizing problem. Contemporary techniques for repair and reconstruction include fusion using rods of tapered diameter alone, or quadruple-rod constructs in which primary rods are joined to floating accessory rods by connectors. Here, we present how we utilized a quadruple-rod construct to perform five C2 to thoracic spine fusions.

Methods:
Our hospital electronic medical record revealed five patients who underwent the four rod C2-thoracic spine fixation. Patients ranged in age from 14-years-old to 78-years-old. The mean operative time was 715.8 min (range 549–987 min), and average estimated blood loss was 878 cc (range 40–1800 cc).

Results:
None of the five patients sustained any intraoperative complications, and none demonstrated progressive kyphotic deformity over the average follow-up interval of 8 months.

Conclusion:
We successfully treated five patients with degenerative or oncologic cervical pathology requiring fixation across the cervicothoracic junction utilizing a 4-rod C2-cervicothoracic fusion technique.