bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solvent Impregnated Polymers Loaded with Liquid‐Like Nanoparticle Organic Hybrid Materials for Enhanced Kinetics of Direct Air Capture and Point Source CO2 Capture
Authors: Rim Guanhe , Feric Tony G. , Moore Thomas , Park Ah‐Hyung Alissa 
Published: March 2021

AbstractHybrid CO2 capture materials, solvent impregnated polymers (SIPs), are developed based on a simple and scalable encapsulation technique to enhance CO2 capture kinetics of water‐lean solvents with high viscosity. Liquid‐like nanoparticle organic hybrid materials functionalized with polyethylenimine (NOHM‐I‐PEI) are incorporated into a shell material and UV‐cured to produce gas‐permeable solid sorbents with uniform NOHMs loading (NPEI‐SIPs). The CO2 capture kinetics of NPEI‐SIPs show a remarkable 50‐fold increase compared to that of neat NOHM‐I‐PEI due to a large increase in the NOHMs‐CO2 interfacial surface area provided by the SIP design. The optimum NOHM‐I‐PEI loading and sorption temperature are found to be ≈49 wt% and 50 °C, respectively, and NPEI‐SIPs exhibit great thermal stability over 20 CO2 capture/sorbent regeneration temperature swing cycles. The pseudoequilibrium CO2 loadings of NPEI‐SIPs under humid conditions are as high as 3.1 mmol CO2 g−1NPEI − SIPs for 15 vol% CO2 (postcombustion capture) and 1.7 mmol CO2 g−1NPEI − SIPs for 400 ppm (direct air capture). These findings suggest that NPEI‐SIPs can effectively capture CO2 from a wide range of CO2 concentrations including direct air capture while allowing the flexible design of CO2 capture reactors by combining the benefits of liquid solvents and solid sorbents.
Lithiation MXene Derivative Skeletons for Wide‐Temperature Lithium Metal Anodes
Authors: Wang Jinming , Yang Meng , Zou Guodong , Liu Di , Peng Qiuming 
Published: March 2021

AbstractLithium (Li) metal, as an appealing candidate for the next‐generation of high‐energy‐density batteries, is plagued by its safety issue mainly caused by uncontrolled dendrite growth and infinite volume expansion. Developing new materials that can improve the performance of Li‐metal anode is one of the urgent tasks. Herein, a new MXene derivative containing pure rutile TiO2 and N‐doped carbon prepared by heat‐treating MXene under a mixing gas, exhibiting high chemical activity in molten Li, is reported. The lithiation MXene derivative with a hybrid of LiTiO2‐Li3N‐C and Li offers outstanding electrochemical properties. The symmetrical cell assembling lithiation MXene derivative hybrid anode exhibits an ultra‐long cycle lifespan of 2000 h with an overpotential of ≈30 mV at 1 mA cm−2, which overwhelms Li‐based anodes reported so far. Additionally, long‐term operations of 34, 350, and 500 h at 10 mA cm−2 can be achieved in symmetrical cells at temperatures of −10, 25, and 50 °C, respectively. Both experimental tests and density functional theory calculations confirm that the LiTiO2‐Li3N‐C skeleton serves as a promising host for Li infusion by alleviating volume variation. Simultaneously, the superlithiophilic interphase of Li3N guides Li deposition along the LiTiO2‐Li3N‐C skeleton to avoid dendrite growth.
Stabilization of Damaged Articular Cartilage with Hydrogel‐Mediated Reinforcement and Sealing
Authors: Patel Jay M. , Loebel Claudia , Saleh Kamiel S. , Wise Brian C. , Bonnevie Edward D. , Miller Liane M. , Carey James L. , Burdick Jason A. , Mauck Robert L. 
Published: March 2021

AbstractCartilage injuries and subsequent tissue deterioration impact millions of patients. Since the regeneration of functional hyaline cartilage remains elusive, methods to stabilize the remaining tissue, and prevent further deterioration, would be of significant clinical utility and prolong joint function. Finite element modeling shows that fortification of the degenerate cartilage (Reinforcement) and reestablishment of a superficial zone (Sealing) are both required to restore fluid pressurization within the tissue and restrict fluid flow and matrix loss from the defect surface. Here, a hyaluronic acid (HA) hydrogel system is designed to both interdigitate with and promote the sealing of the degenerated cartilage. Interdigitating fortification restores both bulk and local pericellular tissue mechanics, reestablishing the homeostatic mechanotransduction of endogenous chondrocytes within the tissue. This HA therapy is further functionalized to present chemo mechanical cues that improve the attachment and direct the response of mesenchymal stem/stromal cells at the defect site, guiding localized extracellular matrix deposition to “seal” the defect. Together, these results support the therapeutic potential, across cell and tissue length scales, of an innovative hydrogel therapy for the treatment of damaged cartilage.
Synthetic Antigen‐Presenting Cells for Adoptive T Cell Therapy
Authors: Dahotre Shreyas N. , Romanov Anna M. , Su Fang‐Yi , Kwong Gabriel A. 
Published: March 2021

AbstractAdoptive T cell therapies are transforming the treatment of solid and liquid tumors, yet their widespread adoption is limited in part by the challenge of generating functional cells. T cell activation and expansion using conventional antigen‐presenting cells (APCs) is unreliable due to the variable quality of donor‐derived APCs. As a result, engineered approaches using nanomaterials presenting T cell activation signals are a promising alternative due to their ability to be robustly manufactured with precise control over stimulation cues. Here, synthetic APCs that consist of liposomes surface‐functionalized with peptide‐major histocompatibility complexes are designed. Synthetic APCs selectively target and activate antigen‐specific T cell populations to levels similar to conventional protocols using nonspecific αCD3 and αCD28 antibodies without the need for costimulation signals. T cells treated with synthetic APCs produce effector cytokines and demonstrate cytotoxic activity when co‐cultured with tumor cells presenting target antigen in vitro. Following adoptive transfer into tumor‐bearing mice, activated cells control tumor growth and improve overall survival compared to untreated mice. Synthetic APCs can potentially be used in the future to improve the accessibility of adoptive T cell therapies by removing the need for conventional APCs during manufacturing.
Controllable Design Coupled with Finite Element Analysis of Low‐Tortuosity Electrode Architecture for Advanced Sodium‐Ion Batteries with Ultra‐High Mass Loading
Authors: Lv Zhiqiang , Yue Meng , Ling Moxiang , Zhang Huamin , Yan Jingwang , Zheng Qiong , Li Xianfeng 
Published: March 2021

AbstractElectrode design enabling more active materials makes it possible to improve the energy density for sodium‐ion batteries (SIBs) on the device level, yet suffer from sluggish ion transport. Herein, a low‐tortuosity Na3V2(PO4)3‐based cathode is demonstrated based on a nonsolvent‐induced phase separation method. The targeted low‐tortuosity morphology can be achieved by thermodynamic and kinetic modulation. Benefiting from the structural advantages, the electrode with an ultra‐high mass loading (60 mg cm−2) and areal capacity (4.0 mAh cm−2) is successfully achieved. Even at a high rate of 10 C, the areal capacity remains 1.0 mAh cm−2. Comprehensive understanding on the effects of low‐tortuosity architecture to the spatial and temporal distribution of the multi‐physical field parameters has been elucidated by the finite element method. A homogeneous Na+ distribution, gentle and uniform local current density, and polarization inside the electrode are illustrated. Combining numerical simulations and experiments, it reveals that the low‐tortuosity architecture can contribute to an impressive ion transport capability and consequently significant improvements in electrochemical performance. This study exhibits a prospective solution for the design and optimization of the low‐tortuosity electrodes with ultra‐high mass loading, which opens a new door for developing advanced SIBs with high energy/power density.
A Review of Existing and Emerging Methods for Lithium Detection and Characterization in Li‐Ion and Li‐Metal Batteries
Authors: Paul Partha P. , McShane Eric J. , Colclasure Andrew M. , Balsara Nitash , Brown David E. , Cao Chuntian , Chen Bor‐Rong , Chinnam Parameswara R. , Cui Yi , Dufek Eric J. , Finegan Donal P. , Gillard Samuel , Huang Wenxiao , Konz Zachary M. , Kostecki Robert , Liu Fang , Lubner Sean , Prasher Ravi , Preefer Molleigh B. , Qian Ji , Rodrigues Marco‐Tulio Fonseca , Schnabel Manuel , Son Seoung‐Bum , Srinivasan Venkat , Steinrück Hans‐Georg , Tanim Tanvir R. , Toney Michael F. , Tong Wei , Usseglio‐Viretta Francois , Wan Jiayu , Yusuf Maha , McCloskey Bryan D. , Nelson Weker Johanna 
Published: March 2021

AbstractWhether attempting to eliminate parasitic Li metal plating on graphite (and other Li‐ion anodes) or enabling stable, uniform Li metal formation in ‘anode‐free’ Li battery configurations, the detection and characterization (morphology, microstructure, chemistry) of Li that cannot be reversibly cycled is essential to understand the behavior and degradation of rechargeable batteries. In this review, various approaches used to detect and characterize the formation of Li in batteries are discussed. Each technique has its unique set of advantages and limitations, and works towards solving only part of the full puzzle of battery degradation. Going forward, multimodal characterization holds the most promise towards addressing two pressing concerns in the implementation of the next generation of batteries in the transportation sector (viz. reducing recharging times and increasing the available capacity per recharge without sacrificing cycle life). Such characterizations involve combining several techniques (experimental‐ and/or modeling‐based) in order to exploit their respective advantages and allow a more comprehensive view of cell degradation and the role of Li metal formation in it. It is also discussed which individual techniques, or combinations thereof, can be implemented in real‐world battery management systems on‐board electric vehicles for early detection of potential battery degradation that would lead to failure.
Dithienylethene‐Based Photochromic Siloles: A Straightforward and Divergent Synthetic Strategy
Authors: Devillard Marc , Nour Eddine Nour , Cordier Marie , Alcaraz Gilles 
Published: March 2021

AbstractA straightforward synthetic methodology for the preparation of photochromic siloles based on the dithienylethene motif is developed. It relies upon an efficient palladium‐catalyzed annulation reaction of a 2,3‐bis(3‐thienyl)‐silirene with terminal alkynes in mild conditions. The reaction is functional group‐tolerant and can be performed in high yields with a variety of functional terminal alkynes. It can even be extended to a polymeric polypropargylmethacrylamide (PPMA) substrate affording the corresponding photochromic polymer with different degree of photochromic unit incorporation by simply adjusting the polymer/ silirene stoichiometric ratio.
Trimetallic Spinel NiCo2−xFexO4 Nanoboxes for Highly Efficient Electrocatalytic Oxygen Evolution
Authors: Huang Yi , Zhang Song Lin , Lu Xue Feng , Wu Zhi‐Peng , Luan Deyan , Lou Xiong Wen (David) 
Published: March 2021

AbstractThe development of efficient and low‐cost electrocatalysts toward the oxygen evolution reaction (OER) is critical for improving the efficiency of several electrochemical energy conversion and storage devices. Here, we report an elaborate design and synthesis of porous Co‐based trimetallic spinel oxide nanoboxes (NiCo2−xFexO4 NBs) by a novel metal‐organic framework engaged strategy, which involves chemical etching, cation exchange, and subsequent thermal oxidation processes. Owing to the structural and compositional advantages, the optimized trimetallic NiCo2−xFexO4 NBs (x is about 0.117) deliver superior electrocatalytic performance for OER with an overpotential of 274 mV at 10 mA cm−2, a small Tafel slope of 42 mV dec−1, and good stability in alkaline electrolyte, which is much better than that of Co‐based bi/monometallic spinel oxides and even commercial RuO2.
Eating disturbances in adults with autism spectrum disorder without intellectual disabilities
Authors: Demartini Benedetta , Nisticò Veronica , Bertino Vincenzo , Tedesco Roberta , Faggioli Raffaella , Priori Alberto , Gambini Orsola 
Published: March 2021

AbstractThere is a growing interest in the relationship between autism spectrum disorders (ASDs) and eating disorders (EDs), two relatively common conditions lying on a spectrum from mild to severe clinical features. However, only limited data are available about pathological eating behaviors throughout adults on the autistic spectrum. The aim of the present study is to assess dysfunctional eating behaviors, including EDs manifestations and ASDs‐related eating disturbances, in a population of adults with ASDs without intellectual disabilities. We recruited 106 adults on the autistic spectrum, without intellectual disability and 103 neurotypical adults (NAs). Participants completed the “Eating Attitude Test” (EAT‐26), to measure symptoms and concerns characteristic of EDs, and the “Swedish Eating Assessment for Autism Spectrum Disorders” (SWEAA), to assess eating behaviors frequently observed within the autistic spectrum. Participants with ASDs scored significantly higher than NA at the EAT‐26 and at the SWEAA. Moreover, participants with ASDs scored higher than NA at the EAT‐26 subscales Dieting and Bulimia. The difference between groups remained significant after controlling for the effect of age, biological sex, and BMI. These results suggest that adults with ASDs without intellectual disability presented not only a higher prevalence of eating disturbances typical of the autistic spectrum, but also other symptoms of EDs in comparison to NA.Lay SummaryFor both scales assessing eating disturbances (EAT‐26 and SWEAA), participants with ASDs scored higher than NA, presenting a higher prevalence both of eating disturbances typical of ASDs and of ED symptoms (distorted body image, tendency toward bulimic behaviors, and self‐control of eating).
Biosynthesis of Sinapigladioside, an Antifungal Isothiocyanate from Burkholderia Symbionts
Authors: Dose Benjamin , Niehs Sarah P. , Scherlach Kirstin , Shahda Sophie , Flórez Laura V. , Kaltenpoth Martin , Hertweck Christian 
Published: March 2021

AbstractSinapigladioside is a rare isothiocyanate‐bearing natural product from beetle‐associated bacteria (Burkholderia gladioli) that might protect beetle offspring against entomopathogenic fungi. The biosynthetic origin of sinapigladioside has been elusive, and little is known about bacterial isothiocyanate biosynthesis in general. On the basis of stable‐isotope labeling, bioinformatics, and mutagenesis, we identified the sinapigladioside biosynthesis gene cluster in the symbiont and found that an isonitrile synthase plays a key role in the biosynthetic pathway. Genome mining and network analyses indicate that related gene clusters are distributed across various bacterial phyla including producers of both nitriles and isothiocyanates. Our findings support a model for bacterial isothiocyanate biosynthesis by sulfur transfer into isonitrile precursors.
Calcium activity in response to nAChR ligands in murine bone marrow granulocytes with different Gr‐1 expression
Authors: Serov Dmitriy , Tikhonova Irina , Safronova Valentina , Astashev Maksim 
Published: March 2021

AbstractPolymorphonuclear neutrophilic granulocytes (PMNs) are the largest proportion of leukocytes in adult human blood that perform numerous functions, including phagocytosis, degranulation, generation of reactive oxygen species, and NETosis. Excessive neutrophil activity associates with hyperinflammation and tissue damage during pathologies such as inflammatory bowel disease, diabetes mellitus, tuberculosis, and coronavirus disease 2019. Nicotinic acetylcholine receptors (nAChRs) can modulate immune cells, including neutrophils, functions, therefore, nAChR ligands are considered as the potent agents for therapy of inflammation. Earlier it was shown, that about 30% of PMNs from the acute inflammatory site responded to nicotine by calcium spikes. In this study, we studied the generation of calcium spikes in murine granulocytes with different maturity level (evaluated by Gr‐1 expression) isolated from bone marrow in response to ligands of nAChRs in control and under chronic nicotine consumption. It was found that nearly 20%–25% cells in the granulocyte population responded to nicotine or selective antagonists of different type of nAChRs (α‐cobratoxin, GIC, and Vc1.1). We demonstrated that in the control group Ca2+‐mobilizing activity was regulated through α7 and α9α10 nAChRs in immature granulocytes (Gr‐1int), whereas in mature granulocytes (Gr‐1hi) it was regulated through α7, α3β2, and α9‐contained nAChRs. Sensitivity of PMNs to nicotine depended on their maturity level after chronic nicotine consumption. Gr‐1int cells responded to nicotine through α7 and α9‐contained nAChRs, while Gr‐1hi did not respond to nicotine. Thus, calcium response to nAChR ligands in bone marrow PMNs depends on their maturity level.
Targeted organizational capability development: Comparative analysis of operational and dynamic capabilities
Authors: Slaouti Abdenour 
Published: March 2021

AbstractManagers often face the need to renew their capabilities in dynamic markets. To increase their chances of success, we first offer a model of the capability‐building process that details five interconnected phases as well as the precautions and conditions to be taken into account for its completion. Our subsequent analysis of 29 empirical studies shows the advantages of integrating the routines of new capabilities, and this, for a successful process. Finally, we identify four situations around the formation of distinct capabilities, which should enlighten managers in their decision‐making in relation to the construction of new organizational capabilities.
Asymmetric Synthesis of Chiral 1,3‐Disubstituted Allylsilanes via Copper(I)‐Catalyzed 1,4‐Conjugate Silylation of α,β‐Unsaturated Sulfones and Subsequent Julia‐Kocienski Olefination
Authors: Wang Xian‐Liang , Yin Xing‐Hao , Xiao Jun‐Zhao , Jia Xue‐Shun , Yin Liang 
Published: March 2021

Main observation and conclusionA general synthesis of chiral 1,3‐disubstituted allylsilanes is established through copper(I)‐catalyzed asymmetric 1,4‐conjugate silylation of α,β‐unsaturated sulfones and subsequent Julia‐Kocienski olefination. By modification of McQuade's NHC ligand, the catalytic asymmetric conjugate silylation with a broad substrate scope is achieved in high enantioselectivity. The following Julia‐Kocienski olefination proceeds smoothly at room temperature to deliver an array of chiral allylsilanes in moderate yields. More interestingly, a one‐pot asymmetric synthesis with high synthetic efficiency is successfully realized. Utility of the prepared chiral 1,3‐disubsituted allylsilanes is demonstrated in the asymmetric allylation of both aldehyde and aldimine. Finally, an interesting “match and mismatch” phenomenon is observed in the asymmetric allylation of chiral aldehydes.
Molecular and clinical predictors of improvement in progression‐free survival with maintenance PARP inhibitor therapy in women with platinum‐sensitive, recurrent ovarian cancer: A meta‐analysis
Authors: Lee Chee Khoon , Friedlander Michael L. , Tjokrowidjaja Angelina , Ledermann Jonathan A. , Coleman Robert L. , Mirza Mansoor R. , Matulonis Ursula A. , Pujade‐Lauraine Eric , Bloomfield Ralph , Goble Sandra , Wang Ping , Glasspool Rosalind M. , Scott Clare L. ,   the Gynecologic Cancer Intergroup Meta‐Analysis Committee
Published: March 2021

BACKGROUNDThe authors performed a meta‐analysis to better quantify the benefit of maintenance poly(ADP‐ribose) polymerase inhibitor (PARPi) therapy to inform practice in platinum‐sensitive, recurrent, high‐grade ovarian cancer for patient subsets with the following characteristics: germline BRCA mutation (gBRCAm), somatic BRCA mutation (sBRCAm), wild‐type BRCA but homologous recombinant‐deficient (HRD), homologous recombinant‐proficient (HRP), and baseline clinical prognostic characteristics.METHODSRandomized trials comparing a PARPi versus placebo as maintenance treatment were identified from electronic databases. Treatment estimates of progression‐free survival were pooled across trials using the inverse variance weighted method.RESULTSFour trials included 972 patients who received a PARPi (olaparib, 31%; niraparib, 35%; or rucaparib, 34%) and 530 patients who received placebo. For patients who had germline BRCA1 mutation (gBRCAm1) (N = 471), the hazard ratio (HR) was 0.29 (95% CI, 0.23‐0.37); for those who had germline BRCA2 mutation (gBRCAm2) (N = 236), the HR was 0.26 (95% CI, 0.17‐0.39); and, for those who had sBRCAm (N = 123), the HR was 0.22 (95% CI, 0.12‐0.41). The treatment effect was similar between the gBRCAm and sBRCAm subsets (P = .48). In patients who had wild‐type BRCA HRD tumors (excluding sBRCAm; N = 309), the HR was 0.41 (95% CI, 0.31‐0.56); and, in those who had wild‐type BRCA HRP tumors (N = 346), the HR was 0.64 (95% CI, 0.49‐0.83). The relative treatment effect was greater for the BRCAm versus HRD (P = .03), BRCAm versus HRP (P < .00001), and HRD versus HRP (P < .00001) subsets. There was no difference in benefit based on age, response after recent chemotherapy, and prior bevacizumab.CONCLUSIONSIn platinum‐sensitive, recurrent, high‐grade ovarian cancer, maintenance PARPi improves progression‐free survival for all patient subsets. PARPi therapy has a similar magnitude of benefit for sBRCAm and gBRCAm. Although patients with BRCAm derive the greatest benefit, the absence of a BRCAm or HRD could not be used to exclude patients from maintenance PARPi therapy.
How to distinguish red coloring matter used in prehistoric time? The contribution of visible near‐infrared diffuse reflectance spectroscopy
Authors: Chalmin Emilie , Schmitt Bernard , Chanteraud Claire , de Kergommeaux Aurélie Chassin , Soufi Fayçal , Salomon Hélène 
Published: March 2021

AbstractAlthough the main prehistoric color used for paintings is red, knowledge of this coloring matter often boils down to saying that it is “ochre.” However, the red coloring matter of Prehistory is numerous and may have been the subject of various preparations, mixtures, or even alterations. Understanding the use and transformation of coloring matter raises questions about the technical processes but also about the supply strategies of these ancient societies. In the case of analysis of solid archaeological remains, we can access the petrography, mineralogy and chemistry of these ferruginous rocks. But, when it is about deposited powder, the means of investigation become limited. We therefore propose to test the complementarity of spectro‐radiometry, a non‐invasive method that allows us to obtain a spectral signature of the material whatever its mode of preparation. From six geological reference samples chosen for their color (from red to yellow) and for their mineralogical composition, spectra in the visible and near‐infrared were recorded under several experimental conditions and several modes of preparation of the matter, using two spectro‐gonio radiometers. It is then possible to discriminate these different coloring matter on the basis of their spectral signature and to understand the link with their mineral composition.