bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early innovations in opioid use disorder treatment and harm reduction during the COVID-19 pandemic: a scoping review
Authors: Krawczyk Noa , Fawole Adetayo , Yang Jenny , Tofighi Babak 
Published: November 2021

Abstract
Background
The COVID-19 pandemic has exerted a significant toll on the lives of people who use opioids (PWUOs). At the same time, more flexible regulations around provision of opioid use disorder (OUD) services have led to new opportunities for facilitating access to services for PWUOs. In the current scoping review, we describe new services and service modifications implemented by treatment and harm reduction programs serving PWUO, and discuss implications for policy and practice.

Methods
Literature searches were conducted within PubMed, LitCovid, Embase, and PsycInfo for English-language studies published in 2020 that describe a particular program, service, or intervention aimed at facilitating access to OUD treatment and/or harm reduction services during the COVID-19 pandemic. Abstracts were independently screened by two reviewers. Relevant studies were reviewed in full and those that met inclusion criteria underwent final data extraction and synthesis (n = 25). We used a narrative synthesis approach to identify major themes around key service modifications and innovations implemented across programs serving PWUO.

Results
Reviewed OUD treatment and harm reduction services spanned five continents and a range of settings from substance use treatment to street outreach programs. Innovative service modifications to adapt to COVID-19 circumstances primarily involved expanded use of telehealth services (e.g., telemedicine visits for buprenorphine, virtual individual or group therapy sessions, provision of donated or publicly available phones), increased take-home medication allowances for methadone and buprenorphine, expanded uptake of long-acting opioid medications (e.g. extended-release buprenorphine and naltrexone), home delivery of services (e.g. MOUD, naloxone and urine drug screening), outreach and makeshift services for delivering MOUD and naloxone, and provision of a safe supply of opioids.

Conclusions
The COVID-19 pandemic has posed multiple challenges for PWUOs, while simultaneously accelerating innovations in policies, care models, and technologies to lower thresholds for life-saving treatment and harm reduction services. Such innovations highlight novel patient-centered and feasible approaches to mitigating OUD related harms. Further studies are needed to assess the long-term impact of these approaches and inform policies that improve access to care for PWUOs.
Comprehensive well-being scale: development and validation among Chinese in recovery of mental illness in Hong Kong
Authors: Sham Will W. L. , Yeung Gladys T. Y. , Mak Winnie W. S. , Powell Candice L. Y. M. 
Published: November 2021

Abstract
Background
Given the absence of a brief scale that reconciles and encompasses different conceptual definitions of well-being (physical, psychological, social and spiritual), the present research aimed at developing and validating a Comprehensive Well-Being Scale (CWBS) that encompasses these different conceptual definition and extend the definition of well-being to transcendental well-being among individuals in recovery of mental illness. The present research focuses on testing the scale among people in recovery of mental illness so that a brief and theoretically comprehensive scale would be available for mental health organization to evaluate the well-being of service users, and to develop and evaluate well-being related services.

Methods
A 56-item preliminary well-being scale was developed by a professional panel. In Study 1, 300 mental health service users in Hong Kong were recruited. Twenty items were selected through principal component analysis to form the CWBS. In Study 2, another sample of 300 service users was recruited. Confirmatory factor analysis was done to confirm a two-factor structure. Validity of the scale was also examined.

Results
The CWBS yielded good internal consistency (Cronbach’s alphas = .79–.91). The finding supported a two-factor structure, namely Intrapersonal Well-Being, and Transpersonal Well-Being, χ2 (169) = 335.61, p < .001, CFI = .90, RMSEA = .06, SRMR = .06.

Conclusions
The CWBS established concurrent and construct validity in assessing well-being among Chinese in recovery of mental illness in Hong Kong. It provided theoretical and practical implications for measuring well-being. Theoretically, it extended the concept of well-being to encompass transcendental well-being in model of recovery among individuals recovery from mental illness. Practically, it provided a tool for evaluation of well-being and service development in mental health organization.
A novel fragmented anode biofilm microbial fuel cell (FAB–MFC) integrated system for domestic wastewater treatment and bioelectricity generation
Authors: Atnafu Tesfalem , Leta Seyoum 
Published: November 2021

Abstract
Background
The critical MFC design challenge is to increase anode surface area. A novel FAB–MFC integrated system was developed and evaluated for domestic wastewater treatment. It was operated in fed-batch flow mode at 1–3 days of HRT with 755 mg/L CODIN and 0.76 kg-COD/m3/day. The study includes anaerobic-MFC and aerobic-MFC integrated systems. Microbial electrode jacket dish (MEJ-dish) with hybrid dimension (HD) was invented, first time to authors’ knowledge, to boost anode biofilm growth. The treatment system with MEJ+ (FAB) and MEJ− (MFC) anode are called FAB–MFC and MFC, respectively.

Results
Fragmented variable anode biofilm thickness was observed in FAB than MFC. The FAB–MFC (FAB+) simple technique increases the anode biofilm thickness by ~ 5 times MFC. Due to HD the anode biofilm was fragmented in FAB+ system than MFC. At the end of each treatment cycle, voltage drops. All FAB+ integrated systems reduced voltage drop relative to MFC. FAB reduces voltage drops better than MFC in anaerobic-MFC from 6 to 20 mV and aerobic-MFC from 35–47 mV at 1 kΩ external load. The highest power density was achieved by FAB in anaerobic-MFC (FAB = 104 mW/m2, MFC = 98 mW/m2) and aerobic-MFC integrated system (FAB = 59 mW/m2, MFC = 42 mW/m2).

Conclusions
The ∆COD and CE between FAB and MFC could not be concluded because both setups were inserted in the same reactor. The integrated system COD removal (78–97%) was higher than the solitary MFC treatment (68–78%). This study findings support the FAB+ integrated system could be applied for real applications and improve performance. However, it might depend on influent COD, the microbial nature, and ∆COD in FAB+ and MFC, which requires further study.

Graphic abstract
True grit: ingestion of small stone particles by hummingbirds in West Mexico
Authors: Maya-García Omar , Ortega-Flores Mauricio , Schondube Jorge E. 
Published: November 2021

AbstractBackgroundGrit is used by birds mainly for grinding hard food items but can also serve a nutritional role as a source of minerals. Ingestion of grit by birds has been documented primarily in species that feed on seeds and invertebrates. Although feeding mainly on nectar and small arthropods, hummingbirds also ingest grit, but why they do so is unclear. We quantified the number of grit particles in the stomachs of six species of hummingbirds during an annual cycle in a seasonal ecosystem of West Mexico.MethodsWe compared the number of grit particles in the stomachs of different hummingbird species (Mexican VioletearColibri thalassinus, Amethyst-throated MountaingemLampornis amethystinus, White-eared HummingbirdBasilinna leucotis, Rivoli’s HummingbirdEugenes fulgens, Broad-tailed HummingbirdSelasphorus platycercus, and Rufous HummingbirdS. rufus), and between sex and age categories during the different seasons of a year. To determine if grit was used to grind ingested arthropods, we examined the relationships between the number of grit particles, the biomass of arthropods ingested, and their chitin content.ResultsAlthough species did not differ in the number of grit particles in their stomachs, we found that grit was mostly ingested by female individuals, with only one male of one species (Mexican Violetear) presenting grit in its stomach. We also found that female hummingbirds had grit in their stomachs during the rainy and the cold-dry season (June–February) but not during the warm-dry season (March–May). Our analyses revealed no relationship between the number of grit particles and the amount of ingested arthropods and arthropod chitin content. However, high grit consumption was related to wasp ingestion on Mexican Violetears.ConclusionsOur results indicate that grit is used mainly by female hummingbirds. The seasonal variation in the ingestion of grit by female individuals suggests that it can be used to meet mineral requirements related to breeding; however, this topic needs further exploration. Additionally, the use of grit was proportionally higher in juvenile individuals, suggesting it is used for grinding arthropods during a period of fast development.
Treatment outcomes of implant-assisted removable partial denture with distal extension based on the Kennedy classification and attachment type: a systematic review
Authors: Putra Wigianto Adityakrisna Yoshi , Goto Takaharu , Iwawaki Yuki , Ishida Yuichi , Watanabe Megumi , Ichikawa Tetsuo 
Published: November 2021

Abstract
Background
Implant-assisted removable partial dentures (IARPDs) have recently become popular, but little information is available on the treatment outcomes based on the Kennedy classification and attachment types.

Objective
The objective of this review was to evaluate the treatment outcomes of IARPD delivered for distal extension edentulous areas based on the differences in the Kennedy classification and attachment type.

Materials and methods
English-language clinical studies on IARPD published between January 1980 and February 2020 were collected from MEDLINE (via PubMed), the Cochrane Library (via the Cochrane Central Register of Controlled Trials), Scopus online database, and manual searching. Two reviewers selected the articles based on pre-determined inclusion and exclusion criteria, followed by data extraction and analysis.

Results
Eighty-one studies were selected after evaluating the titles and abstracts of 2410 papers. Nineteen studies were finally included after the perusal of the full text. Fourteen studies focused on Class I, 4 studies investigated both Class I and II, and only 1 study was conducted on Kennedy’s class II. Eight types of attachments were reported. The ball attachment was the most frequently used attachment, which was employed in 8 of the included studies. The implant survival rate ranged from 91 to 100%. The reported marginal bone loss ranged from 0.3 mm to 2.30 mm. The patient satisfaction was higher with IARPD than with conventional RPDs or that before treatment. The results of prosthetic complications were heterogeneous and inconclusive.

Conclusion
IARPD exhibited favorable clinical outcomes when used as a replacement for distal extension edentulous areas. The comparison between the clinical outcomes of Kennedy’s class I and II was inconclusive owing to the lack of studies focusing on Kennedy Class II alone. The stud attachment was the most commonly used type in IARPDs. Overall, the different attachment systems did not influence the implant survival rate and patient satisfaction. Further high-quality studies are needed to investigate the attachment systems used in IARPD.
Enhancing banknote authentication by guiding attention to security features and manipulating prevalence expectancy
Authors: van der Horst Frank , Snell Joshua , Theeuwes Jan 
Published: November 2021

AbstractAll banknotes have security features which are intended to help determine whether they are false or genuine. Typically, however, the general public has limited knowledge of where on a banknote these security features can be found. Here, we tested whether counterfeit detection can be improved with the help of salient elements, designed to guide bottom-up visuospatial attention. We also tested the influence of the participant’s a priori level of trust in the authenticity of the banknote. In an online study (N = 422), a demographically diverse panel of Dutch participants distinguished genuine banknotes from banknotes with one (left- or right-sided) counterfeited security feature. Either normal banknotes (without novel design elements) or banknotes that contained a salient element (a pink rectangular frame) were presented for 1 s. To manipulate the participant’s level of trust, trials were administered in three blocks, whereby at the start of each block, participants were instructed that either one third, one half, or two thirds of the upcoming banknotes were counterfeit (though the true ratio was always 1:1). We hypothesized (i) that in the presence of a salient element, counterfeits would be better detected when the location of the salient element aligned with the location of the counterfeited security feature—i.e. that it would act as an attentional cue; and (ii) that this effect would be stronger with lower trust. Our hypotheses were partly confirmed: counterfeit detection improved with ‘valid cues’ and decreasing trust, but the level of trust did not modulate the cueing effect. As the overall detection performance was rather poor, we replicated the study with a sample of university students (N = 66), this time presenting stimuli until response. While indeed observing better overall performance, all other patterns were replicated. Our results provide evidence that attention can be guided to enhance banknote authentication.
Evaluation of insecticidal potential of organochemicals on SF9 cell line
Authors: Pandya Nishi , Thakkar Bhumi , Pandya Parth , Parikh Pragna 
Published: November 2021

Abstract
Background
Organophosphates and Pyrethroids are the most widely used pesticides worldwide and are known to have significant toxicity on the nervous system of the target pest. Assessment for combined toxicity of Organophosphate and Pyrethroid on Sf9 (Spodoptera frugiperda) cells is less explored. The present study demonstrates and compares the two organochemicals whose trade names are Ammo and Profex, for its cytotoxic potential on the insect Sf9 cells. Ammo and Profex were selected as the test chemicals as toxicity of these insecticides at molecular and cellular level is poorly understood.

Results
The results of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay demonstrated that Ammo and Profex exhibited significant cytotoxicity to Sf9 cells in a time- and dose-dependent manner. In our study, the IC50 value was obtained by MTT assay and the sub-lethal concentrations (IC50/20-17.5 µg/ml, IC50/10-35 µg/ml, and IC50/5–70 µg/ml for Ammo and IC50/20-20 µg/ml, IC50/10-40 µg/ml, and IC50/5-80 µg/ml for Profex) were selected for further tests. Acridine orange/ethidium bromide staining proved the apoptotic cell death on exposure of both the insecticides confirming its toxic potential. Furthermore, antioxidant status was assessed using DCF-DA staining and both the insecticides resulted into an increased reactive oxygen species (ROS) generation. A dose- and time-dependent significant (p < 0.05) alterations in lipid peroxidase (LPO), glutathione (GSH) and catalase (CAT) activity were observed.

Conclusion
The results showed that both Ammo and Profex triggered apoptosis in Sf9 cells through an intrinsic mitochondrial pathway via the generation of ROS. Of the two insecticides, Ammo was found to be more toxic compared to Profex. The present study is important to evaluate the environmental safety and risk factors of Organochemicals’ exposure to crops and livestock.
Regulated free banking in Switzerland (1881–1907)
Authors: Herger Nils 
Published: November 2021

AbstractThe free-banking history of Switzerland is subdivided into periods with unfettered competition (1826–1881), and strict banknote regulation (1881–1907). This paper suggests that the Federal Banknote Act of 1881 was introduced to remedy the fragmentation of the unfettered-competition period, during which private note-issuing banks were unable to issue standardised paper money. Although the corresponding minimum-reserve and mutual-acceptance rules led to a standardisation, they created new problems. For example, these regulatory interventions reduced the flexibility (or “elasticity”) of the paper-money supply. It turned out that a central note-issuing bank is needed to supply adequate amounts of standardised banknotes.
A comprehensive review on RAGE-facilitated pathological pathways connecting Alzheimer’s disease, diabetes mellitus, and cardiovascular diseases
Authors: Chakraborty Agnila , Sami Saad Ahmed , Marma Kay Kay Shain 
Published: November 2021

Abstract
Background
Alzheimer’s disease (AD), cardiovascular disease (CVD), and diabetes are some of the most common causes of morbidity and mortality among the aging populations and cause a heavy burden on the worldwide healthcare system. In this review, we briefly highlighted cellular inflammation-based pathways of diabetes mellitus and CVD through receptor for advanced glycation end products AGEs or RAGE leading to Alzheimer’s disease and interrelation between these vascular and metabolic disorders. The articles were retrieved from Google Scholar, Science Direct, and PubMed databases using the following terms: Alzheimer’s; AGEs; RAGE; RAGE in Alzheimer’s; AGEs in Alzheimer’s; RAGE in diabetes; RAGE related pathways of CVD; RAGE in hypertension; RAGE and RAS system; RAGE and oxidative stress.

Main body of the abstract
AD is a neurodegenerative disease characterized by cognitive dysfunction and neuronal cell death. Vascular complications like hypertension, coronary artery disease, and atherosclerosis as well as metabolic syndromes like obesity and diabetes are related to the pathophysiology of AD. RAGE plays significant role in the onset and progression of AD. Amyloid plaques and neurofibrillary tangles (NFT) are two main markers of AD that regulates via RAGE and other RAGE/ligands interactions which also induces oxidative stress and a cascade of other cellular inflammation pathways leading to AD. Though AD and diabetes are two different disorders but may be inter-linked by AGEs and RAGE. In long-term hyperglycemia, upregulated AGEs interacts with RAGE and produces reactive oxygen species which induces further inflammation and vascular complications. Aging, hypercholesterolemia, atherosclerosis, hypertension, obesity, and inflammation are some of the main risk factors for both diabetes and dementia. Chronic hypertension and coronary artery disease disrupt the functions of the blood-brain barrier and are responsible for the accumulation of senile plaques and NFTs.

Short conclusion
RAGE plays a role in the etiology of Aβ and tau hyperphosphorylation, both of which contribute to cognitive impairment. So far, targeting RAGE may provide a potential sight to develop therapies against some metabolic disorders.
Evaluation of tool performance and wear through vibration signature analysis in drilling of IS3048 steel
Authors: Sridhar Annavarapu Venkata , Prasad Balla Srinivasa , Mouli K. V. V. N. R. Chandra 
Published: November 2021

AbstractIn this paper, a connection between vibration amplitude and tool wear when drilling of IS3048 steel utilizing different dimensioned tools is dissected through tests. Discriminant features, which are sensitive to drill wear and breakage, were developed. These were discovered to be somewhat impervious toward sensor location and cutting conditions. In the process, the vibration amplitude features a checking highlight dependent on ascertaining both the tools and their performance over vibrations, which was discovered to be somewhat powerful for on-line identification of drill tool breakage in both frequency and time domains. These vibrational amplitude signal features are directly affected, related to the tool geometry, which give higher chances of tool selection criteria during the drilling process. The experiments were carried out using solid carbide tool with change in tool geometry under dry conditions where the vibration amplitude for both is evaluated. The results revealed that cutting tool vibrational amplitude and tool wear were relatively dependent showing the tool selection of suitable tool geometry.
Distinct Survival Outcomes in Subgroups of Stage III Pancreatic Cancer Patients: Taiwan Cancer Registry and Surveillance, Epidemiology and End Results registry
Authors: Lu Tzu-Pin , Wu Chien-Hui , Chang Chia-Chen , Chan Han-Ching , Chattopadhyay Amrita , Lee Wen-Chung , Chiang Chun-Ju , Lee Hsin-Ying , Tien Yu-Wen 
Published: November 2021

Abstract
Purpose
Pancreatic cancer is one of the most malignant cancers with poor survival. The latest edition of the American Joint Committee on Cancer (AJCC) staging system classifies the majority of operable pancreatic cancer patients as stage-III, while dramatic heterogeneity is observed among these patients. Therefore, subgrouping is required to accurately predict their prognosis and define a treatment plan. This study conducts a cohort study to provide a more precise classification system for stage-III pancreatic cancer patients by utilizing clinical variables.

Methods
We analyzed survival using log-rank tests, univariate Cox-regression models, and Kaplan-Meier survival curves for stage-III pancreatic ductal adenocarcinoma (PDAC) patients from the Taiwan Cancer Registry (TCR). Patients were further divided into subgroups using classification and regression tree (CART) algorithm. All results were validated using the SEER database.

Results
Among stage-III PDAC patients, lymph node and tumor grade showed significant association with survival. Patients with N2 stage had higher mortality risks (hazard ratio [HR] = 2.30, 95% confidence interval [CI] 1.71–3.08, p < 0.0001) than N0 patients. Patients with grade 3 also had higher risk of mortality (HR = 3.80, 95% CI 2.25–6.39, p < 0.0001) than grade 1 patients. The CART algorithm stratified stage-III patients into four subgroups with significantly different survival rates. The median survival of the four subgroups was 23.5, 18.4, 14.5, and 9.0 months, respectively (p < 0.0001). Similar results were observed with SEER data.

Conclusions
Lymph node involvement and tumor grade are predictive factors for survival in stage-III PDAC patients. This new precise classification system can be used to guide treatment planning in advanced-stage pancreatic cancer.