bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a new hybrid model to enhance streamflow estimation using artificial neural network and reptile search algorithm
Authors: Bahmani Mohammad Javad , Kayhomayoon Zahra , Milan Sami Ghordoyee , Hassani Farhad , Malekpoor Mohammadreza , Berndtsson Ronny 
Published: February 2025

Abstract
A new metaheuristic optimizer combined with artificial neural networks is proposed for streamflow prediction. Hence, the study aimed to forecast monthly streamflow of the main rivers in Urmia, Iran, by considering data shortage and using artificial neural network (ANN) models. By combining three variables: temperature, precipitation, and streamflow, we formulated five patterns, where 70% of the data were used for model training, and 30% for model testing. To improve the performance of ANN, we evaluated a new optimization algorithm, reptile search algorithm (RSA), and compared the results with combinations of ANN, particle swarm optimization algorithm (PSO), and whale optimization algorithm (WOA) models. The results of the ANN + RSA were promising at most stations and patterns. At Band station streamflow simulation testing gave RMSE, MAE, and NSE of 1.65, 1.21 MCM/month, and 0.80, respectively. At Babaroud station they were 4.01, 3.0 MCM/month and 0.68, respectively, at Nazlo station 5.62, 3.79 MCM/month, and 0.69, respectively, and at Tapik station 5.69, 3.82 MCM/month, and 0.59, respectively. However, the results of the ANN + PSO hybrid model were better than ANN + RSA. The impact of different parameters on the accuracy of streamflow prediction varied depending on model and streamflow station, indicating that the models do not perform consistently across different locations, times, and conditions. The inclusion of lagged monthly streamflow in the model was an influential input parameter. The results demonstrated that the new algorithm consistently improved predictions, enhancing the performance of traditional algorithms. The findings of this study highlight advantage of the ANN + RSA hybrid model for specific areas, suggesting its potential application in other similar hydrological problems for further validation.
Glucose-derived receptors for photo-controlled binding of amino acid esters in water
Authors: Most Mario M. , Boll Linus B. , Gödtel Peter , Pianowski Zbigniew L. , Lewandowski Bartosz 
Published: February 2025

Abstract
Selective receptors of amino acids in aqueous media are highly sought after as they may enable the creation of novel diagnostic and sensing tools. Photoswitchable receptors are particularly attractive for such purposes as their response and selectivity towards bioanalytes can be modulated using light. Herein we report glucose-based photoswitchable receptors of amino-acid methyl esters and biogenic amines in water. The tetra-ortho-fluoroazobenzene unit in the receptors structure allows to control the distance between their binding sites using light. The Z-isomers of both receptors, having these sites in closer proximity, bind lysine, ornithine and arginine esters significantly stronger compared to E-isomers, where the binding sites are further apart.
Targeting cIAP2 in a novel senolytic strategy prevents glioblastoma recurrence after radiotherapy
Authors: Tomimatsu Nozomi , Di Cristofaro Luis Fernando Macedo , Kanji Suman , Samentar Lorena , Jordan Benjamin Russell , Kittler Ralf , Habib Amyn A , Espindola-Netto Jair Machado , Tchkonia Tamara , Kirkland James L , Burns Terry C , Sarkaria Jann N , Gilbert Andrea , Floyd John R , Hromas Robert , Zhao Weixing , Zhou Daohong , Sung Patrick , Mukherjee Bipasha , Burma Sandeep 
Published: February 2025

Abstract
Glioblastomas (GBM) are routinely treated with high doses of ionizing radiation (IR), yet these tumors recur quickly, and the recurrent tumors are highly therapy resistant. Here, we report that IR-induced senescence of tumor cells counterintuitively spurs GBM recurrence, driven by the senescence-associated secretory phenotype (SASP). We find that irradiated GBM cell lines and patient derived xenograft (PDX) cultures senesce rapidly in a p21-dependent manner. Senescent glioma cells upregulate SASP genes and secrete a panoply of SASP factors, prominently interleukin IL-6, an activator of the JAK-STAT3 pathway. These SASP factors collectively activate the JAK-STAT3 and NF-κB pathways in non-senescent GBM cells, thereby promoting tumor cell proliferation and SASP spreading. Transcriptomic analyses of irradiated GBM cells and the TCGA database reveal that the cellular inhibitor of apoptosis protein 2 (cIAP2), encoded by the BIRC3 gene, is a potential survival factor for senescent glioma cells. Senescent GBM cells not only upregulate BIRC3 but also induce BIRC3 expression and promote radioresistance in non-senescent tumor cells. We find that second mitochondria-derived activator of caspases (SMAC) mimetics targeting cIAP2 act as novel senolytics that trigger apoptosis of senescent GBM cells with minimal toxicity towards normal brain cells. Finally, using both PDX and immunocompetent mouse models of GBM, we show that the SMAC mimetic birinapant, administered as an adjuvant after radiotherapy, can eliminate senescent GBM cells and prevent the emergence of recurrent tumors. Taken together, our results clearly indicate that significant improvement in GBM patient survival may become possible in the clinic by eliminating senescent cells arising after radiotherapy.
Skills Associated With Atypical Phonological Errors in English: A Scoping Review
Authors: Roepke Elizabeth 
Published: February 2025

Purpose:
Few clinicians report incorporating error type in their assessment of speech sound disorders, despite research reporting differences between children who produce typical and atypical phonological errors. The purpose of this scoping review was to map what is currently known about the related skills of English-speaking children who produce typical versus atypical phonological errors in order to summarize currently available evidence for clinical decision making concerning atypical phonological errors.

Method:
A systematic search of databases was completed, including PubMed, Scopus, and APA PsycInfo. Studies that were published between 1985 and 2023, were peer-reviewed, and reported on a related skill for typical and atypical phonological errors were included. The scoping review was reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines.

Results:
Twenty-seven studies were included in the review. These studies were organized into six themes: persistence of speech errors, emergent literacy difficulties, executive function difficulties, language skills, speech perception and auditory processing, and motor skills. Atypical but not typical phonological errors were related to persistence of speech errors. Emergent literacy difficulties, particularly phonological awareness difficulties, and executive function difficulties were frequently reported to be associated with atypical but not typical phonological errors. Motor skills were similar for children who produced typical and atypical errors. More research is needed for speech perception, auditory processing, and language skills.

Conclusions:
Children who produce atypical phonological errors have different strengths and weaknesses in related skills than children who produce typical phonological errors. Children who produce atypical phonological errors may benefit from phonological awareness and/or early literacy assessments and intervention.
Antithrombotic Treatment for Left Ventricular Assist Devices: One Does Not Fit All
Authors: Scala Emmanuelle , Othenin-Girard Alexandra 
Published: February 2025

AbstractAs the prevalence of heart failure is increasing globally, left ventricular assist devices (LVADs) have become essential therapeutic options in managing advanced heart failure. This review explores the development of LVAD technology, with a focus on the shift from pulsatile to continuous-flow devices, particularly the HeartMate 3, the most advanced generation of LVADs. The evolution in design has significantly enhanced patient survival and quality of life. However, hemocompatibility-related adverse events (HRAEs)—such as pump thrombosis, ischemic and hemorrhagic strokes, and gastrointestinal bleeding—remain major clinical challenges. Striking the delicate balance between preventing thromboembolic events and minimizing hemorrhagic risks remains critical in LVAD patient management. Current therapeutic strategies typically involve long-term anticoagulation with vitamin K antagonists and antiplatelet therapy, though optimal management must be individualized based on patient-specific factors and device characteristics. Emerging alternatives, including low-dose anticoagulation, direct oral anticoagulants such as apixaban, and aspirin-free regimens, offer promising potential to reduce adverse outcomes. This review also highlights the role of innovative mechanical designs in minimizing shear stress and alternative treatments in preventing complications like gastrointestinal bleeding. Despite these advancements, personalized treatment strategies are critical, as no single therapeutic regimen fits all LVAD recipients. Ongoing research into both device technology and pharmacological therapies is essential to further reduce HRAEs and improve long-term outcomes for LVAD patients.
Guidance-Based Appropriateness of Hemostasis Testing in the Acute Setting
Authors: Devis Luigi , Arachchillage Deepa J. , Hardy Michael , Mansour Alexandre , Catry Emilie , Closset Mélanie , Gouin-Thibault Isabelle , Frere Corinne , Lecompte Thomas , Alberio Lorenzo , Cadamuro Janne , Lippi Giuseppe , Mullier François 
Published: February 2025

AbstractIn this review, we aim to highlight the extent of inappropriate hemostasis testing and provide practical guidance on how to prevent it. We will focus on the acute setting, including but not limited to the emergency department and intensive care unit. To this end, we will first discuss the significance of inappropriateness, in the general context of laboratory medicine. This includes acknowledging the importance of the phenomenon and attempting to define it. Next, we describe the harmful consequences of inappropriate testing. Finally, we focus on the inappropriate use of hemostasis testing in the acute setting. The second section describes how interventions―in particular, the implementation of guidance for testing—can efficiently reduce inappropriateness. In the third section, we summarize the available recommendations for rational use of hemostasis testing (platelet count, activated partial thromboplastin time, prothrombin time/international normalized ratio, fibrinogen, thrombin time, D-dimer, anti-Xa assay, antithrombin, ADAMTS13 activity, antiheparin-PF4 antibodies, viscoelastometric tests, coagulation factors, and platelet function testing), as supported by guidelines, recommendations, and/or expert opinions. Overall, this review is intended to be a toolkit in the effort to promote the appropriate use of hemostasis testing. Hopefully, the new In Vitro Diagnostic Medical Device Regulation (EU) 2017/746 (IVDR) should help in improving the availability of evidence regarding clinical performance of hemostasis assays.
Rhodium(III)-Catalyzed C–C Bond Formation by Direct C–H Activation
Authors: Luo Haiqing , Li Xiaolan 
Published: February 2025

AbstractTransition-metal-catalyzed functionalizations of C–H bonds to construct C–C bonds represent an ideal route in the synthesis of valuable organic molecules. In particular, rhodium(III)-catalyzed C–H bond activation offers an attractive strategy due to its efficiency and step economy for direct functionalization in organic synthesis. Consequently, recent developments in this area have assured a high level of regioselectivity in C–H functionalization reactions. In this Account, we have summarized our recent achievements in the functionalizations of sp2- and sp3-C–H bonds using rhodium catalyst. The scope, limitation, and mechanism of these reactions have been described briefly.1	Introduction2	C–H Arylation2.1	Aromatic C(sp2)–H Arylation2.2	Benzylic C(sp3)–H Arylation2.3	Olefinic C(sp2)–H Arylation3	Olefinic C(sp2)–H Alkenylation and Alkylation4	Olefinic C(sp2)–H Heteroarylation5	Conclusion
Deep learning enabled photonic Nyquist folding receiver for wideband RF spectral analysis
Authors: Murray Matthew J. , Schermer Ross T. , Hart Joseph , Murray Joseph B. , Redding Brandon 
Published: February 2025

The need for real-time wideband radio frequency (RF) spectral analysis is driven by continued advances in modern wireless communications and RADAR systems used both for military and civilian applications. However, wideband RF sensing presents a challenge for typical high-speed analog to digital converters (ADC) since ADCs capable of operating continuously are typically limited to monitoring less than 1 GHz bands. Here, we leverage the high bandwidth of photonics to build a Nyquist folding receiver (NYFR) that uses an asymmetric optical frequency comb and a deep convolutional neural network to monitor a ∼5 GHz bandwidth using a 1 GS/s ADC with a 1 MHz update rate. We tested the deep-learning assisted NYFR on several signal classes, including linear chirps, nonlinear chirps, and continuous wave signals. The system presented here tackles many of the limitations of typical NYFR systems, including the ability to recover signals that cross Nyquist zones and the ability to detect multiple signals simultaneously. We also show that using a non-linear encoding to map the RF signal into the optical domain can improve the accuracy of the recovered RF spectrum.
Optimizing food management: Effective strategies for minimizing food loss and waste
Authors: Jaswal Anita , Mehta Chandra Mohan , Kaur Sawinder , El Kadili Sara , Assouguem Amine , Lahlali Rachid 
Published: February 2025

Abstract
Yearly, more than 33% of the food produced for human use is lost or discarded. This statement serves as a critical signal regarding the exhaustion of natural resources utilized in the food supply chain (FSC), which could potentially have adverse consequences on food security. Food wastage predominantly occurs at the consumer level, namely in the retail and food service industries. It is more prevalent in affluent nations compared to food loss, which occurs between manufacturing and distribution and is more common in low-income countries. Hence, the prevention of food loss and waste (FLW) can contribute to a more equitable equilibrium between food supply and demand. This is of utmost importance in enhancing food security, mitigating environmental consequences, and yielding financial advantages for the many stakeholders engaged in the FSC. This article provides a comprehensive analysis of case studies, legislative examples from different countries, and initiatives undertaken by non-profit organizations and industry actors in the food chain to efficiently prevent and/or decrease FLW. Furthermore, it enumerates the current limitations and prospective avenues for further investigation. To optimize the allocation of resources, it is essential to analyze and combine information, while also being cognizant of the specific locations in the food chain, categories of food, and countries experiencing the greatest losses.
High Quality Single Crystal of Kitaev Spin Liquid Candidate Material RuBr3 Synthesized under High Pressure
Authors: Zhang Bowen , Li Xiangjun , Yan Limin , Li Wenbo , Li Nana , Zhao Jianfa , Liu Xiaobing , Yu Shun-Li , Hu Zhiwei , Yang Wenge , Yu Runze 
Published: February 2025

Abstract
Kitaev quantum spin liquids have attracted significant attention in condensed matter physics over the past decade. To understand their emergent quantum phenomena, high-quality single crystals of substantial size are essential. Here, we report the synthesis of single crystals of the Kitaev quantum spin liquid candidate RuBr3, achieving millimeter-sized crystals through a self-flux method under high pressure and high temperature conditions. The crystals exhibit well-defined cleavage planes with a lustrous appearance. Transport characterizations exhibit a narrow band-gap semiconducting behavior with 0.13 eV and 0.11 eV band-gap in ab plane and along c axis, respectively. Magnetic measurement shows a transition to antiferromagnetic (AFM) state at approximately 29 K both in ab plane and along c axis. Notably, the Néel temperature increases to 34 K with an applied magnetic field of up to 7 T in the ab plane, but without any change along c axis. The large size and high quality of RuBr3single crystals provide a valuable platform for investigating various interactions, particularly the Kitaev interaction, and for elucidating the intrinsic physical properties of Kitaev quantum spin liquids.
AV3Sb5 kagome superconductors: a review with transport measurements
Authors: Xu Zhuokai , Le Tian , Lin Xiao 
Published: February 2025

Abstract
Kagome systems have garnered considerable attention due to the unique features of the sublattice structure and band topology. The recently discovered kagome metals AV3Sb5 (where A = K, Rb, Cs) host a rich array of symmetry-breaking phases, including exotic charge density waves (CDW), electronic nematicity, pair density waves (PDW) and superconductivity. Despite extensive experimental and theoretical investigations into the diverse phases, several key issues remain contentious, such as a solid clarification of the time-reversal symmetry breaking (TRS-breaking) in the CDW order and its implications for the nature of superconducting (SC) pairing symmetry. This review aims to shed light on the transport properties of these intertwined phases, emphasizing the pivotal role that transport measurements play in uncovering the non-trivial quantum states of matter.
Geometric Inequality for Axisymmetric Black Holes With Angular Momentum
Authors: Feng Xuefeng , Yan Ruodi , Gao Sijie , Lau Yun-Kau , Yau Shing-Tung 
Published: February 2025

Abstract
In an effort to understand the Penrose inequality for black holes with&#xD; angular momentum, an axisymmetric, vacuum, asymptotically Euclidean initial data&#xD; set subject to certain quasi stationary conditions is considered for a case study. A new&#xD; geometric definition of angular velocity of a rotating black hole is defined in terms of&#xD; the momentum constraint, without any reference to a stationary Killing vector field.&#xD; The momentum constraint is then shown to be equivalent to the dynamics of a 2d&#xD; steady compressible fluid flow governed by a quasi-conformal mapping. In terms of&#xD; spinors, a generalised first law for rotating black holes (possibly with multi-connected&#xD; horizon located along the symmetry axis) is then proven and may be regarded as a&#xD; Penrose type inequality for black holes with angular momentum.
A MIMO system identification approach for the longitudinal control of the filter cavity of the advanced virgo gravitational-wave detector
Authors: Tapia San Martín Enzo Nicolás , Guo Yuefan , Vardaro Marco , Zhao Yuhang , Capocasa Eleonora , Flaminio Raffaele , Tacca Matteo 
Published: February 2025

Abstract
The sensitivity of the second generation ground-based gravitational-wave detectors is mostly limited by quantum noise. The injection of frequency-dependent squeezed vacuum states into the output port of the interferometer has been shown to reduce quantum noise across the entire detector bandwidth. Frequency dependent squeezed states are generated by reflecting a frequency independent squeezed states off a detuned optical cavity: the phase response of the cavity rotates the squeeze angle as a function of frequency. The precision of the longitudinal control of the such cavity, known as filter cavity, is one of the key parameters affecting the quantum noise suppression factor. The target longitudinal control precision was achieved by simultaneously acting on both the cavity length and the frequency of the squeezing main laser. In this scenario, the analysis of this system requires a Multiple-Input Multiple-Output (MIMO) system model. In this work, we demonstrate that a MIMO model is required and show that a MIMO system identification technique is effective to characterize the system and improve its robustness. Ultimately we show that these techniques allow the design of robust filters that can keep the cavity residual length fluctuations below 1 pm, allowing for a quantum noise reduction of 4.5 dB at high frequencies and 2 dB at low frequencies in the Advanced Virgo interferometer.
Multistep transferable prediction of shield attitude and position in shield tunneling based on PCA and deep learning method
Authors: Zhang Jian , Ding Xiaobin , Deng Tao , Zheng Lu , Chen Guangqi 
Published: February 2025

Abstract
Maintaining the alignment of the shield tunneling axis with the designed tunnel axis is crucial in urban subway construction. However, previous studies have only verified the accuracy of the models in a specific project, ignoring model transferability. This paper proposes a multistep transferable prediction method (PCA-GRU) for shield attitude and employs feature importance analysis of the PCA-GRU model through feature dimensionality reduction experiments. Datasets obtained from the Guangzhou and Fuzhou Metro Line X Projects were used to validate the accuracy of the proposed method. The results revealed that PCA can unify the model input, enabling the model to be applied to different projects, and the proposed model could produce an accurate prediction within 24 steps, with an average R2
of 0.94 and 0.97 in the Guangzhou and Fuzhou projects. This indicates that the proposed model possesses transferability and generalization ability, which can aid decision-making during urban subway construction.
Multi-technique-based electrochemical sensing of lipoarabinomannan (LAM) antigen as a biomarker for early-stage tuberculosis diagnosis
Authors: Rotake Dinesh Ramkrushna , Anjankar Shubham C , Singh Shiv Govind 
Published: February 2025

Abstract
Tuberculosis (TB) remains a pressing global health challenge, necessitating precise and reliable biomarkers for early detection. Lipoarabinomannan (LAM), an FDA-approved biomarker (Monoclonal Antibody-MBS320597), holds significant potential due to its association with the Mycobacterium tuberculosis cell wall. This study systematically evaluates LAM concentrations ranging from 1 pg/mL to 6 ng/mL using Square Wave Voltammetric (SWV) analysis, achieving an exceptional detection limit (LOD) of 0.077 pg/mL. A comprehensive review of current diagnostics highlights critical gaps, including limitations in speed and accuracy, underscoring the urgency for advanced methodologies. In this study, LAM’s performance is assessed by analyzing spiked urine samples, demonstrating its high sensitivity, specificity, and reliability as an early-stage TB biomarker. By comparing findings with existing diagnostic tools and addressing identified limitations, this study emphasizes LAM's potential to transform TB diagnostic strategies. These results contribute to global efforts to improve early detection, enhance patient outcomes, and pave the way for future advancements in TB diagnostics.