bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetic Thermoresponsive Nanocomposite for Targeted PARP-1&nbsp;in Colorectal Adenocarcinoma, an Approach for Tumor Dual Therapy
Authors: Gamal Alaa , El-sayed El-Sayed , El-Hamoly Tarek , Kahil Heba 
Published: March 2021

Abstract
Background

The current study presents a bimodal therapeutic platform for cancer treatment. Bimodal implies that the presented drug loaded core-shell structure is capable of elevating the tumor tissue temperature (hyperthermia) through the superparamagnetic iron oxide core and simultaneously release a Poly (ADP-ribose) polymerase-1(PARP-1)-modifying agent from the thermoresponsive shell. The capability of Superparamagnetic iron oxide nanoparticles (SPIONs) as successful hyperthermia agents is well established. Likewise, poly-n-isopropylacrylamide (PNIPAAm) is a widely used thermoresponsive polymer. Together, they constitute the magnetic thermoresponsive nanocomposite (MTN). To the authors knowledge, the combination of magnetic nanocomposites with PARP-1 modifying agents has not been investigated. Therefore, in this work, 5-aminoisoquinoline (5-AIQ) is loaded on the thermoresponsive polymer to constitute MTN.5-AIQ.
Results

Structural characterization of the formed composite is studied via various experimental tools. The lower critical solution temperature (LCST) is determined by differential scanning calorimetry (DSC) method. The results confirm the formation of magnetic thermoresponstive nanocomposite (MTN) with excellent potential for hyperthermia. A high drug loading efficiency (85.72%) is obtained with convenient temperature dependent drug release kinetics. Biocompatibility and cytotoxic efficacy are tested on an in vivo and in vitro colorectal-adenocarcinoma models, respectively. MTN.5-AIQ administration exhibits normal hepatic and renal functions as well as lower toxic effect on normal tissue. In addition, the composite effectively inhibits Caco-2 cells viability upon incubation.
Conclusions

Based on the obtained results, the proposed therapeutic platform can be considered as a novel, promising candidate as dual therapy for colorectal adenocarcinoma exhibiting a PARP-1 overexpression.
A New Scheme To Enhance The Performance Of Permutation Index-Differential Chaos Shift Keying Communications System
Authors: Albassam Nizar , Al-Jerew Oday 
Published: March 2021

Abstract
In this paper, a new scheme based on permutation index-differential chaos shift keying is proposed, modeled, and evaluated in AWGN channel environment. Data is sent by frames, each frame is headed by a single reference signal and followed by some information bearing signals. Modulation is performed through permutations of a reference signal according to the mapped data. At the receiver, each incoming information bearing signal undergoes all inverse permutation possibilities to perform a correlation with the delayed and stored version of the received reference signal. To decode the information bits, the detector selects the highest correlator outputs.

The proposed scheme named Single Reference-Permutation Index-Differential Chaos Shift Keying (SR-PI-DCSK) is an enhanced version of PI-DCSK, and uses a single reference signal for multiple information bearing ones. Hence, the energy requirement is saved by almost a half. The bit error performance is studied using the baseband system model and analytically tested using Gaussian Approximation (GA) method. Results show the BER performance outperforms other standard and recently developed differentially coherent chaos systems, including Permutation Index-DCSK by an average of $2.25$~db. Moreover, the analytical form which is developed to predict the Bit Error Rate (BER) is validated by simulation. Results demonstrate the performance in AWGN is closely matching with the simulation results, particularly at high SNR.
Challenges, coping responses and supportive interventions for international and migrant students in academic nursing programs in major host countries: A scoping review with a gender lens
Authors: Merry Lisa , Vissandjée Bilkis , Verville-Provencher Kathryn 
Published: March 2021

Abstract
Background: International and migrant students face specific challenges which may impact their mental health, well-being and academic outcomes, and these may be gendered experiences. The purpose of this scoping review was to map the literature on the challenges, coping responses and supportive interventions for international and migrant students in academic nursing programs in major host countries, with a gender lens.Methods: We searched 10 databases to identify literature reporting on the challenges, coping responses and/or supportive interventions for international and migrant nursing students in college or university programs in Canada, the United-States, Australia, New Zealand or a European country. We included peer-reviewed research (any design), discussion papers and literature reviews. English, French and Spanish publications were considered and no time restrictions were applied. Drawing from existing frameworks, we critically assessed each paper and extracted information related to gender.Results: 114 publications were included. Overall the literature mostly focused on international students, and migration history/status and length of time in country were not considered with regards to challenges, coping or interventions. Females and males, respectively, were included in 69% and 59% of studies with student participants, while those students who identify as other genders were not named or identified in any of the research. Several papers suggest that foreign-born nursing students face challenges associated with different cultural roles, norms and expectations for men and women. Other challenges included perceived discrimination due to wearing a hijab and being a ‘foreign-born male nurse’, and in general nursing being viewed as a feminine, low-status profession. Only two strategies, accessing support from family and other student mothers, used by female students to cope with challenges, were identified. Supportive interventions considering gender were also limited; these included matching students with support services personnel by sex, involving male family members in admission and orientation processes, and using patient simulation as a method to prepare students for care-provision of patients of the opposite-sex.Conclusion: Future research and discussion papers in nursing higher education, especially those regarding supportive interventions, need to address the intersections of gender/gender identity and migration/international status, and also consider the complexity of students’ migration contexts.
Sperm cryopreservation and in vitro fertilization techniques for the African turquoise killifish Nothobranchius furzeri
Authors: Dolfi Luca , Suen Tsz Kin , Ripa Roberto , Antebi Adam 
Published: March 2021

Abstract
Over the last decade, the African turquoise killifish, Nothobranchius furzeri, has emerged as an important model system for the study of vertebrate biology and ageing. N. furzeri propagation, however, can pose challenges due to the short window of fertility, the efforts and space requirements involved in continuous strain maintenance, and the risks of inbreeding. The current method for long term strain preservation relies on arrest of embryos in diapause. Though useful, it remains unclear how long embryos can survive in this state. To create an alternative for long term maintenance, we developed a robust protocol to cryopreserve and revive sperm for in vitro fertilization (IVF). We tested a variety of extender and activator buffers for sperm IVF, as well as cryoprotectants to achieve feasible long-term storage and fertilization conditions tailored to this species. Our protocol enabled sperm to be preserved in a cryogenic condition for months and to be revived an average of 40% viability upon thawing. Thawed sperm were able to fertilize nearly the same number of eggs as natural fertilization, with an average of ~25% and peaks of ~55% fertilization. This technical advance will greatly facilitate the use of N. furzeri as a model organism.
Research on Enterprise Business Model and Technology Innovation Based on Artificial Intelligence
Authors: Qu Sunping , Shi Hongwei , Zhao Huanhuan , Yu Lin , Yu Yunbo 
Published: March 2021

Abstract
Small and medium-sized enterprises (SEMs) are the important part of economic society whose innovation activities are of have great significance for building innovative country. In order to investigate how technological innovation (TI) and business model design (BMD) affect the business performance (BP) of SMEs, samples of 268 SMEs in the artificial intelligence industry and hierarchical regression models are used in the analysis. The results indicate that TI, BMD, and the matching of them have different effects on the innovation of SMEs of different sizes. These findings are helpful for enriching the theory of the fit between TI and BMD and providing theoretical guidance for the innovation activities in SEMs.
Nogo-A mediated endoplasmic reticulum stress during myocardial ischemic-reperfusion injury in diabetic rats
Authors: xiong yonghong , leng yan , li wei , li wenyuan , chen rong , xue rui , xia zhongyuan 
Published: March 2021

Abstract
Background: Diabetic myocardial ischemia reperfusion (MI/R) injury is aggravated after myocardial infarction, which leads to myocardial damage. Molecular mechanisms associated with the diabetic ischemia-related cardiac diseases are not yet fully understood. Nogo-A is an endoplasmic reticulum (ER) protein ubiquitously expressed in tissues including in the heart. However, the mechanisms that account for the Nogo-A in MI/R injury remain unknown. Methods: SD (Sprague Dawley) rats were subjected to 45 min of ischemia, followed by 3 h reperfusion. Rats were injection with streptozotocin (60mg/kg), tauroursodeoxycholic acid injection (100mg/kg) or corresponding controls just prior to MI/R. Blood and heart samples were collected at 3 h post-reperfusion. Serum LDH and CK-MB, myocardial infarct size, histopathologic changes, apotosis and ER stress were analyzed to evaluate MI/R injury. Signaling pathways were also investigated in vitro using embryonic rat cardiomyocyte-derived H9c2 cells cultures to identify underlying mechanisms for Nogo-A in diabetic MI/R injury. Results: TUDCA treatment significantly reduced Nogo-A, GRP78 and CHOP levels, diminished myocardial infarct areas, attenuated ER stress and decreased myocardial apoptosis after MI/R. ER stress signaling was significantly decreased in the TUDCA-treated MI/R group compared with controls. The effect of Nogo-A was abrogated by pretreatment with knockdown CHOP. A positive feedback loop between Nogo-A and CHOP was found leading to an enhanced ER stress in diabetic MI/R injure. Conclusions: Our data suggest that Nogo-A mediated ER stress plays a major role in diabetic MI/R injury and Nogo-A might be a key regulator of ER stress.
The Impact of Tenderness on Prefrontal Cortical Hemodynamics: An Objective Measurement of Wrist-ankle Acupuncture Analgesic Bracelet
Authors: Du Jiahao , Liu Junwen , Fang Fanfu , Yu Hongliu , Shi Ping 
Published: March 2021

Abstract
Background: Determining an objective measure for pain is one of the most significant challenges in neuroscience and clinical medicine. The response of the cerebral cortex to noxious stimuli/pain can be detected by functional near infrared spectroscopy (fNIRS). The study aimed to examine the law of pain relief and cerebral blood volume dynamics based on the wrist-ankle acupuncture (WAA) analgesic bracelet, and determined the reliability of the cortical activation patterns as objective measurements of pain. Methods: Tenderness was performed on the left point Jianyu of volunteers (age, 23.9 ± 1.9 years, mean ± SD) suffering from the cervical-shoulder syndrome (CSS) as tasks. A transcutaneous electrical nerve stimulation analgesic bracelet based on WAA in traditional Chinese medicine (TCM) was used for treatment. A 24-channel fNIRS system was used for measuring cerebral oxygenated hemoglobin (Oxy-Hb) levels. Oxy-Hb concentration changes in each channel were determined by calculating the differences of Oxy-Hb levels between task and rest. Paired t-tests (p< 0.05) were used to assess the difference in data during tasks and rest. Results: A significant increase in Oxy-Hb was found in all 12 channels of the participants’ right hemisphere during the three tenderness tasks. The mean ± SD of Oxy-Hb levels changes in three tenderness were 0.50±1.22 mM mm, 0.28±1.36 mM mm, 0.09±0.81 mM mm, respectively, and the amount of the change gradually decreased with the participation of the analgesic bracelet. Group analysis of the three tenderness tasks showed that the main activation channels of the cerebral cortex for tenderness were CH6, CH11, CH12, and cortical regions response to tenderness were the frontopolar area, dorsolateral prefrontal cortex, and includes frontal eye fields. With the participation of the analgesic bracelet, the activation area of the cerebral cortex for tenderness gradually decreases. Conclusions: These findings describe the cerebral blood volume dynamics and cortical activation patterns during shoulder tenderness measured by fNIRS, which can not only be used to assess patients with CSS and other shoulder pain, but also to determine the reliability of the cerebral blood volume dynamics and cortical activation patterns pain assessment indicators. Further, this research explores the objective evaluation of the efficacy of an analgesic bracelet based on WAA in TCM for the first time, and provides a new research direction for further pain relief. Trial registration: Chinese Clinical Trial Registry, ChiECRCT20200243. Registered 12 May 2020.
Nanostructured Ag3PO4 from natural phosphate: High-efficient catalytic reduction of 4-nitrophenol and antibacterial studies.
Authors: DÄNOUN KARIM , Tabit Rida , Laghzizil Abdelaziz , Zahouily Mohamed 
Published: March 2021

Abstract
In this paper, a novel approach was successfully developed for preparing nanostructured Ag3PO4 using Moroccan phosphate as a source for phosphorus precursor. The as-synthetized nanomaterial was characterized using various techniques. A pure crystalline Ag3PO4 phase was obtained after drying, exhibiting a mesoporous structure with specific surface area of 35 m2 g− 1. The use of this simple, environmentally friendly, and inexpensive procedure can be useful for the development of nanostructured Ag3PO4 catalyst with excellent catalytic activity for reduction of 4-nitrophenol to 4-aminophenol in the presence of NaBH4 as reducing agent. Furthermore, the Ag3PO4 material was also used as an antibacterial agent against Escherichia-coli and Staphylococcus-aureus bacteria.
Bibliometric Analysis of Studies on Tumor Organoids
Authors: Chen Qiwei , Zhang Yu , Li Kun , Zhang Zhikai , Wang Ya , Mu Guoyu 
Published: March 2021

Abstract
Background: Organoid is an artificially grown mass of cells or tissues, which is similar to an organ. It can replicate the complexity of an organ and can be used for gaining a better understanding of diseases. In this study, the hot spots of “organoids” were classified into 6 categories and 10 aspects, and organoids used for studying genetic mechanisms, drug effect, and metabolism of tumors showed the greatest potential for future development.Methods: A total of 1550 articles relevant to organoid in tumor research field were recruited as research samples. High-frequency words and text/co-word matrix were constructed by BICOMB software. gCLUTO software was applied to analyze the matrix by double-clustering and visual analysis subsequently to identify the hotspot in this area.Results: We constructed a text and co-word matrix composed of 21 high-frequency words and 1550 articles and generated a hotspot “peak map” based on double-clustering analysis. The strategic coordinates approach was used to assess the research prospects of each hotspot and the connections between these hotspots.Conclusions: In this study, we classified the hot-spots of “organoid” into 6 categories and 10 aspects. Calculation and analysis revealed that the field of tumor organoid shows a slight trend of polarization, and organoid for studying the genetic mechanisms, drug effects and metabolism of tumor shows the greatest potential for future development.
Identification, Characterization&nbsp;and Site-Saturation Mutagenesis&nbsp;of a&nbsp;Thermostable ω-Transaminase From Chloroflexi&nbsp;Bacterium
Authors: Wang Chen , Tang Kexin , Dai Ya , Jia Honghua , Li Yan , Gao Zhen , Wu Bin 
Published: March 2021

Abstract
In present study, we have mined a ω-transaminase (ω-TA) from Chloroflexi bacterium from genome database by using an ω-TA sequence ATA117 Arrmut11 from Arthrobacter sp . KNK168 and an amine transaminase from Aspergillus terreus as templates in a BLASTP search and motif sequence alignment. The protein sequence of the ω-TA from C. bacterium shows 38% sequence identity to ATA117 Arrmut11. The gene sequence of the ω-TA was inserted into pRSF-Duet1 and functionally expressed in E. coli BL21(DE3). Results showed that the recombinant ω-TA has a specific activity of 1.19 U/mg at pH 8.5, 40 °C. The substrate acceptability test showed that ω-TA has significant reactivity to aromatic amino donors and amino receptors. More importantly, the ω-TA also exhibited a good affinity towards some cyclic substrates such as 1-Boc-3-piperidone. The homology model of the ω-TA was built by Discovery Studio and docking was performed to describe the relative activity towards some substrates. The ω-TA was evolved by site-saturation mutagenesis and found that the Q192G mutant increased the activity to the (R)-α-methylbenzylamine (MBA) by around seven-fold. The Q192G mutant was then used to convert two cyclic ketones, N -Boc-3-pyrrolidinone and N -Boc-3-aminopiperidine, and the conversions were both improved compared to the parental ω-TA.
The Role of Maternal Ideations on Breastfeeding Practices in Northwestern Nigeria: a Cross-sectional Analysis
Authors: Anaba Udochisom , Johansson Emily White , Abegunde Dele , Adoyi Gloria , Umar-Farouk Olayinka , Abdu-Aguye Shittu , Hewett Paul C , Hutchinson Paul L 
Published: March 2021

Abstract
Background Early initiation of breastfeeding (EIBF) within the first hour of birth and exclusive breastfeeding (EBF) for the first six months of life are beneficial for child survival and long-term health. Yet breastfeeding rates remain sub-optimal in Northwestern Nigeria, and such practices are often influenced by complex psychosocial factors at cognitive, social and emotional levels. To understand these influences, we developed a set of breastfeeding-related ideational factors and quantitatively examined their relationship with EIBF and EBF practices. Methods A cross‐sectional population‐based survey was conducted in Kebbi, Sokoto, and Zamfara states from September through October 2019. A random sample of over 3000 women with at least one child under 2 years was obtained. Respondents were asked about their health behaviors including breastfeeding practices for their youngest child under 2 years. Breastfeeding-related ideations were developed using the Ideation Model of Strategic Communication and Behavior Change. Mixed-effects logistic regression models were used to derive predicted probabilities for EIBF and EBF while adjusting for ideations and socio-demographic variables. Results Among 3039 women with a child under 2 years of age, 42.1% (95% CI: 35.1% - 49.4%) practiced EIBF, while 37.5% (95% CI: 29.8% - 46.0%) out of 721 infants aged 0-5 months were exclusively breastfed. Women who knew that EIBF was protective on the health of the newborn had 7.9 and 7.0 percentage points (pp) higher likelihood of EIBF and EBF practices respectively. Women who believed colostrum was harmful both had 8.4 pp lower likelihood of EIBF and EBF practices. We found a higher likelihood of practicing EIBF (5.1 pp) and EBF (13.3 pp) among women who knew at least one benefit of breastfeeding. Knowledge of the appropriate time to introduce complementary feeding and having self-efficacy to practice EBF were positively associated with 11.2 pp and 13.1 pp increased likelihood of practicing EBF alone. Household wealth, maternal occupation and attending ANC4+ times were associated with EIBF, while health provider’s influence was associated with EBF. Conclusion Social and Behavior Change (SBC) programs should focus on improving women’s knowledge about breastfeeding and its benefits, dispelling myths around colostrum as bad milk, building women’s confidence to exclusively breastfeed, and improving antenatal care uptake to support breastfeeding promotion.
Infanticide, Neonaticide and Post-neonaticide: Racial/ethnic Disparities in the United States.
Authors: Salihu Hamisu M. , Gonzales Danielle N , Dongarwar Deepa 
Published: March 2021

Abstract
This study aims to assess recent trends and characteristics for infanticide and the sub-groups: neonaticide and post-neonaticide during the time period 2003–2017. Multiple Cause-of-Death Mortality Data were used to identify infanticides in the United States based on ICD-10 codes. Joinpoint regression analysis was used to calculate trends in the rates of infanticide, neonaticide and post-neonaticide during the study period. Logistic regression was used to examine the association between the socio-demographic characteristics and each of the outcomes. During the study period, 4,545 (1.2%) infants were identified as being victims of infanticide. The rates of neonaticide declined by 4.2% over the study period, whereas that of infanticide and post-neonaticide remained statistically unchanged. Males and Non-Hispanic (NH) Blacks were more likely to be victims of infanticide and post-neonaticide, compared to females and NH-Whites respectively, but had similar likelihood of neonaticide. While foreign-born residents exhibited nearly a four-fold increased likelihood of neonaticide, they had about 70% lesser likelihood of post-neonaticide than US born residents. Conclusion: Reasons for the disparities found in this study are multifactorial. We believe that access to healthcare needs to be improved and community resources need to be made more available to address the proposed mechanisms that lead to infanticide.