bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telmisartan use and risk of dementia in type 2 diabetes patients with hypertension: A population-based cohort study
Authors: Liu Chi-Hung , Sung Pi-Shan , Li Yan-Rong , Huang Wen-Kuan , Lee Tay-Wey , Huang Chin-Chang , Lee Tsong-Hai , Chen Tien-Hsing , Wei Yi-Chia 
Published: July 2021

BackgroundAngiotensin receptor blockers (ARBs) may have protective effects against dementia occurrence in patients with hypertension (HTN). However, whether telmisartan, an ARB with peroxisome proliferator-activated receptor γ (PPAR-γ)–modulating effects, has additional benefits compared to other ARBs remains unclear.Methods and findingsBetween 1997 and 2013, 2,166,944 type 2 diabetes mellitus (T2DM) patients were identified from the National Health Insurance Research Database of Taiwan. Patients with HTN using ARBs were included in the study. Patients with a history of stroke, traumatic brain injury, or dementia were excluded. Finally, 65,511 eligible patients were divided into 2 groups: the telmisartan group and the non-telmisartan ARB group. Propensity score matching (1:4) was used to balance the distribution of baseline characteristics and medications. The primary outcome was the diagnosis of dementia. The secondary outcomes included the diagnosis of Alzheimer disease and occurrence of symptomatic ischemic stroke (IS), any IS, and all-cause mortality. The risks between groups were compared using a Cox proportional hazard model. Statistical significance was set atp< 0.05. There were 2,280 and 9,120 patients in the telmisartan and non-telmisartan ARB groups, respectively. Patients in the telmisartan group had a lower risk of dementia diagnosis (telmisartan versus non-telmisartan ARBs: 2.19% versus 3.20%; HR, 0.72; 95% CI, 0.53 to 0.97;p= 0.030). They also had lower risk of dementia diagnosis with IS as a competing risk (subdistribution HR, 0.70; 95% CI, 0.51 to 0.95;p= 0.022) and with all-cause mortality as a competing risk (subdistribution HR, 0.71; 95% CI, 0.53 to 0.97;p= 0.029). In addition, the telmisartan users had a lower risk of any IS (6.84% versus 8.57%; HR, 0.79; 95% CI, 0.67 to 0.94;p= 0.008) during long-term follow-up. Study limitations included potential residual confounding by indication, interpretation of causal effects in an observational study, and bias caused by using diagnostic and medication codes to represent real clinical data.ConclusionsThe current study suggests that telmisartan use in hypertensive T2DM patients may be associated with a lower risk of dementia and any IS events in an East-Asian population.
Emergent canine visceral leishmaniasis in Argentina: Comparative diagnostics and relevance to proliferation of human disease
Authors: Fujisawa Kyoko , Silcott-Niles Charlotte , Simonson Poppy , Lamattina Daniela , Humeres Cristian A. , Bhattacharyya Tapan , Mertens Pascal , Thunissen Caroline , O’Rourke Victoria , Pańczuk Magdalena , Whitworth James A. , Salomón Oscar Daniel , Miles Michael A. 
Published: July 2021

Background
Visceral leishmaniasis (VL) is a zoonotic protozoal vector-borne disease that is a major public health challenge. In Argentina, canine (CVL) and human visceral leishmaniasis (HVL) have recently emerged. There is a lack of standardised diagnostic tests for CVL, which hinders control of CVL and HVL.

Methodology/Principal findings
Sampling was carried out in Puerto Iguazú, Argentina, comprising 190 asymptomatic, oligosymptomatic and polysymptomatic dogs. The following diagnostics were applied: microscopy of lymph node aspirate (LNA); three immunochromatographic rapid diagnostic tests (RDTs), prototype rK28-ICT, rK39-ICT (both Coris BioConcept), commercial rK39 (InBios); ELISA for IgG, IgG1 and IgG2, against rK28, rK39 or crude lysate antigen. DNA detection and analysis, with 30 dogs, was of the ITS1 region using skin samples, and loop-mediated isothermal amplification (LAMP; Eiken Loopamp) of buffy coat, skin scrape or LNA. 15.4% of dogs were positive by LNA microscopy. The rK28 RDT had higher seropositivity rate (61%) than either a prototype rK39 RDT (31.4%) or commercial rK39 RDT (18.8%), without cross-reactivity with six other pathogens. IgG anti-rK39 ELISA antibody titres, but not IgG2, were positively correlated with number of clinical signs. LAMP with LNA had a higher positivity rate than PCR; buffy coat sampling was more sensitive than skin scrape. ITS1 confirmed Leishmania (Leishmania) infantum as the agent of CVL. Leishmania (Viannia) spp. was detected in skin samples from two dogs, compatible with Leishmania (Viannia) braziliensis.

Conclusions/Significance
Seroprevalence confirmed rapid increase in CVL in Puerto Iguazú. The rK28 RDT test potentially has great value for improved point-of-care diagnosis. Given cost reduction and accessibility, commercial LAMP may be applicable to buffy coat. RDT biomarkers of CVL clinical status are required to combat spread of CVL and HVL. The presence of Viannia, perhaps as an agent of human mucocutaneous leishmaniasis (MCL), highlights the need for vigilance and surveillance.
The impact of dengue illness on social distancing and caregiving behavior
Authors: Schaber Kathryn L. , Morrison Amy C. , Elson William H. , Astete-Vega Helvio , Córdova-López Jhonny J. , Ríos López Esther Jennifer , Flores W. Lorena Quiroz , Santillan Alfonso S. Vizcarra , Scott Thomas W. , Waller Lance A. , Kitron Uriel , Barker Christopher M. , Perkins T. Alex , Rothman Alan L. , Vazquez-Prokopec Gonzalo M. , Elder John P. , Paz-Soldan Valerie A. 
Published: July 2021

Background
Human mobility among residential locations can drive dengue virus (DENV) transmission dynamics. Recently, it was shown that individuals with symptomatic DENV infection exhibit significant changes in their mobility patterns, spending more time at home during illness. This change in mobility is predicted to increase the risk of acquiring infection for those living with or visiting the ill individual. It has yet to be considered, however, whether social contacts are also changing their mobility, either by socially distancing themselves from the infectious individual or increasing contact to help care for them. Social, or physical, distancing and caregiving could have diverse yet important impacts on DENV transmission dynamics; therefore, it is necessary to better understand the nature and frequency of these behaviors including their effect on mobility.

Methodology and principal findings
Through community-based febrile illness surveillance and RT-PCR infection confirmation, 67 DENV positive (DENV+) residents were identified in the city of Iquitos, Peru. Using retrospective interviews, data were collected on visitors and home-based care received during the illness. While 15% of participants lost visitors during their illness, 22% gained visitors; overall, 32% of all individuals (particularly females) received visitors while symptomatic. Caregiving was common (90%), particularly caring by housemates (91%) and caring for children (98%). Twenty-eight percent of caregivers changed their behavior enough to have their work (and, likely, mobility patterns) affected. This was significantly more likely when caring for individuals with low “health-related quality of well-being” during illness (Fisher’s Exact, p = 0.01).

Conclusions/Significance
Our study demonstrates that social contacts of individuals with dengue modify their patterns of visitation and caregiving. The observed mobility changes could impact a susceptible individual’s exposure to virus or a presymptomatic/clinically inapparent individual’s contribution to onward transmission. Accounting for changes in social contact mobility is imperative in order to get a more accurate understanding of DENV transmission.
Compliance, practices, and attitudes towards VTIs (Vehicle Technical Inspections) in Spain: What prevents Spanish drivers from checking up their cars?
Authors: Alonso Francisco , Useche Sergio A. , Gene-Morales Javier , Esteban Cristina 
Published: July 2021

ObjectiveMechanical conditions of vehicles may play a determinant role in driving safety, the reason why vehicle periodical technical inspections (VTIs) are mandatory in many countries. However, the high number of drivers sanctioned for not complying with this regulation is surprisingly high, and there is not much evidence on what kind(s) of motives may explain this concerning panorama. This study aimed to identify the aspects that modulate the relationship between complying (or not) with VTI’s standards in a nationwide sample of Spanish drivers. The study design also addressed the drivers’ awareness regarding different risky behaviors while driving, depending on their sex and their crash record.Methods1,100 Spanish drivers completed a survey on the aforementioned issues. An analysis of variance (ANOVA) with Bonferroni post-hoc adjustment was conducted to assess significant differences (p<0.05) in the study variables.ResultsMost of the surveyed drivers (99.18%) reported that they always comply with VTI’s requirements. The main reasons to comply were related to compliance with traffic regulation and fear of penalties, while the reasons attributed to its incompliance are, instead, stated as involuntary.ConclusionThe findings of this study support the idea that more actions are needed to increase drivers’ awareness of the relevance of VTIs for road safety, as well as warning them about the dangers of neglecting vehicle checking beyond merely punishing measures. For this reason and given the greater prevalence of the issue among younger segments of the driving population, it is suggested that more emphasis on the matter could be made during novice driver’s training.
A longitudinal course pilot to improve surgical resident acquisition of quality improvement skills
Authors: Ahuja Vanita , Gorecka Jolanta , Yoo Peter , Emerson Beth L. 
Published: July 2021

Problem
Despite mounting evidence that incorporation of QI curricula into surgical trainee education improves morbidity and outcomes, surgery training programs lack standardized QI curricula and tools to measure QI knowledge. In the current study, we developed, implemented, and evaluated a quality improvement curriculum for surgical residents.

Intervention
Surgical trainees participated in a longitudinal, year-long (2019–2020) curriculum based on the Institute for Healthcare Improvement’s online program. Online curriculum was supplemented with in person didactics and small group projects. Acquisition of skills was assessed pre- and post- course via self-report on a Likert scale as well as the Quality Improvement Knowledge Application Tool (QIKAT). Self-efficacy scores were assessed using the General Self-Efficacy Scale. 9 out of 18 total course participants completed the post course survey. This first course cohort was analyzed as a pilot for future work.

Context
The project was developed and deployed among surgical residents during their research/lab year. Teams of surgical residents were partnered with a faculty project mentor, as well as non-physician teammates for project work.

Impact
Participation in the QI course significantly increased skills related to studying the process (p = 0.0463), making changes in a system (p = 0.0167), identifying whether a change leads to an improvement (p = 0.0039), using small cycles of change (p = 0.0000), identifying best practices and comparing them to local practices (p = 0.0020), using PDSA model as a systematic framework for trial and learning (p = 0.0004), identifying how data is linked to specific processes (p = 0.0488), and building the next improvement cycle upon success or failure (p = 0.0316). There was also a significant improvement in aim (p = 0.037) and change (p = 0.029) responses to one QIKAT vignette.

Lessons learned
We describe the effectiveness of a pilot longitudinal, multi component QI course based on the IHI online curriculum in improving surgical trainee knowledge and use of key QI skills.
The Evaluation of Parental Acceptance Towards Children with Sex Chromosomal Disorders of Sex Development Using A Mixed-Method
Authors: Fitrianingrum Iit , Ediati Annastasia , Winarni Tri Indah , Faradz Sultana MH 
Published: July 2021

Background: Sex chromosomal Disorder of sex development (DSD) is an atypical abnormality of external genitalia which is mismatched with its sex chromosome traits. The condition of children with DSD affects the dynamics in the family. Parents’ reactions after discovering this health problem vary greatly, such as being in a state of shock, confusion, or self-blame. However, parents’ acceptance is extremely important for better quality of caring, to the healthy social and emotional child development, and to make the best decisions regarding gender assignment.Objective: To describe the acceptance process of parents that have children with sex chromosomes mosaicism DSD.Methods: This study used a mixed-method with a sequential explanatory approach, which was preceded by quantitative data collection followed by qualitative. The total respondents consisted of 14 mothers and 12 fathers of 14 sex chromosome mosaicism DSD patients with XX/XY, X/XY, XYY or XXY variants. Quantitative data were collected using the Indonesian version of the Parental Acceptance-Rejection Questionnaire (PARQ), and interviews were conducted to determine the acceptance process.Results: Most acceptance cases were based on the surgical stage completion in which a higher number of mothers (71.43%) than fathers (50%).Conclusion: It is uneasy for parents to accept children with sex chromosome mosaicisms DSD, hence the fathers struggle more than mothers in accepting those affected. To the best of our knowledge this is the first study in Indonesia to help parent understand and accept their child condition.
Deamidation and glycation of a Bacillus licheniformis α-amylase during industrial fermentation can improve detergent wash performance
Authors: Pontoppidan Connie , Kaasgaard Svend G. , Sønksen Carsten P. , Andersen Carsten , Svensson Birte 
Published: July 2021

Abstract
The industrial thermostable Bacillus licheniformis α-amylase (BLA) has wide applications, including in household detergents, and efforts to improve its performance are continuously ongoing. BLA during the industrial production is deamidated and glycated resulting in multiple forms with different isoelectric points. Forty modified positions were identified by tandem mass spectrometric peptide mapping of BLA forms separated by isoelectric focusing. These modified 12 asparagine, 9 glutamine, 8 arginine and 11 lysine residues are mostly situated on the enzyme surface and several belong to regions involved in stability, activity and carbohydrate binding. Eight residues presumed to interact with starch at the active site and surface binding sites (SBSs) were subjected to mutational analysis. Five mutants mimicking deamidation (N→D, Q→E) at the substrate binding cleft showed moderate to no effect on thermostability and k
cat and K
M for maltoheptaose and amylose. Notably, the mutations improved laundry wash efficiency in detergents at pH 8.5 and 10.0. Replacing three reducing sugar reactive side chains (K→M, R→L) at a distant substrate binding region and two SBSs enhanced wash performance especially in liquid detergent at pH 8.5, slightly improved enzymatic activity and maintained thermostability. Wash performance was most improved (5-fold) for the N265D mutant near substrate binding subsite +3.
Decomposing Employment Trends of Disabled Workers
Authors: Koning Pierre , Vethaak Heike 
Published: July 2021

Abstract
This paper estimates Age–Period–Cohort models on employment rates of Dutch Disability Insurance (DI) applicants. We find that the substantial decrease in employment between 1999 and 2013 is explained by year-of-application cohort effects and that period effects are negligible. In turn, application cohort effects partly stem from increasing shares of applicants without permanent contracts. Changes in application cohort effects are largely confined to the years following two DI reforms that increased self-screening among workers. We next analyze changes in employment rates of awarded and rejected applicants and follow a Difference-in-Differences approach. Assuming common compositional cohort effects, we infer negligible effects of changes in benefit conditions.
IUPAC first Virtual World Chemistry Congress and General Assembly
Authors: Burford Neil 
Published: July 2021

Abstract
On behalf of the Organizing Committee for IUPAC|CCCE 2021, I am delighted to invite you to the 51st IUPAC General Assembly (GA) and 48th World Chemistry Congress (WCC), in conjunction with the 104th Canadian Chemistry Conference and Exhibition (CCCE). The IUPAC|CCCE 2021 events will be hosted by the Canadian Society for Chemistry (CSC), the Canadian National Committee for IUPAC (CNC-IUPAC) and the National Research Council Canada (NRC). Canada has previously hosted the IUPAC GA & WCC in Vancouver (1981) and Ottawa (2003). The original plans for IUPAC|CCCE 2021 were for the events to take place in Montréal, QC, Canada, 13-20 August 2021. Unfortunately, as travel to Montréal are impeded by the global pandemic, all events associated with IUPAC|CCCE 2021 will occur virtually. As chemical sciences professionals, we know conferences are a key venue for professional development, networking, and scientific advancement, and we will work to ensure that these principles stand true for the virtual event as well. While not a replacement for in-person events, this new endeavour will synthesize the best of our in-person events, with the convenience and accessibility of a virtual event. Beyond that, a virtual experience provides unique opportunities to engage a global audience, reach more young professionals, reduce our environmental impact, and stay safe.
Strategies for Success as an Industrial Chemist
Authors: Ribes Carolyn 
Published: July 2021

Abstract
Chemists find careers in the chemical industry very rewarding. The focus is on applied chemistry and in delivering solutions that meet customer needs, whether the customers are other industrial companies or individual consumers. Chemistry provides solutions to the global challenges facing our society, including the need for clean water, nutritious food, improved healthcare and wellness, affordable housing, and sustainable infrastructure. Within industry, chemists serve in a wide variety of roles. The largest fraction may be in research and development (R&D), although opportunities in manufacturing, technical service and development, supply chain, marketing, intellectual property protection, sales and commercial functions, and many other options are also open to chemists who want to apply their skills [1]. I was drawn to a career in industry because I’m results oriented and I wanted my work to be applied immediately and have an impact.
COMEST: Ethical Advice across Scientific and Geographic Borders
Authors: Sydnes Leiv K. 
Published: July 2021

Abstract
COMEST, an acronym for the French name of the World Commission on the Ethics of Scientific Knowledge and Technology [1], is an advisory body within United Nations Educational, Scientific and Cultural Organization (UNESCO) and a forum of reflection, “mandated to formulate ethical principles that could provide decision-makers with criteria that extend beyond purely economic considerations.” [2] Over the years, the Commission has addressed ethical issues in many areas where science and technology have an impact on people, nature, and society. The deliberations result in reports, which are put forward to the biannual General Conference of UNESCO for discussion and adoption. The outcome has often been ethical recommendations and guidelines to consider and hopefully abide to so that science can interact with society in a responsible way and without adverse consequences.
Topological Formulae for the Zeroth Cohomology of Line Bundles on del Pezzo and Hirzebruch Surfaces
Authors: Brodie Callum R. , Constantin Andrei , Deen Rehan , Lukas Andre 
Published: July 2021

Abstract
We show that the zeroth cohomology of effective line bundles on del Pezzo and Hirzebruch surfaces can always be computed in terms of a topological index.
A dossier on COVID-19 chronicle
Authors: Rufaida  , Mahmood Tarique , Kedwai Ismail , Ahsan Farogh , Shamim Arshiya , Shariq Mohammad , Parveen Saba 
Published: July 2021

Abstract
The dissemination of the 2019 novel coronavirus (2019-nCoV) is presenting the planet with a new health emergency response or threat to health. The virus emerged in bats and was disseminated to humans in December 2019 via still unknown intermediate species in Wuhan, China. It is disseminated by inhalation or breaks out with infected droplets and the incubation period is between 2 and 14 days. The symptoms usually include high body temperature, cough, sore throat, dyspnea, low energy or tiredness, and weakness. The condition is moderate in most people; but in the elderly and those with comorbidities, it advances to pneumonia, acute respiratory distress syndrome (ARDS), and multiple organ failure. Popular research work includes normal/low WBC with upraised C-reactive protein (CRP). Treatment is generally supportive and requires home seclusion of suspected persons and rigorous infection control methods at hospitals. The Covid-19 has lower fatality than SARS and MERS. Among the proposed therapeutic regimen, hydroxychloroquine, chloroquine, remdisevir, azithromycin, toclizumab, and cromostat mesylate have shown promising results, and the limited benefit was seen with lopinavir–ritonavir treatment in hospitalized adult patients with severe COVID-19. Early development of the SARS-CoV-2 vaccine started based on the full-length genome analysis of severe acute respiratory syndrome coronavirus. Several subunit vaccines, peptides, nucleic acids, plant-derived, and recombinant vaccines are under pipeline. Research work, development of new medicines and vaccines, and efforts to reduce disease morbidity and mortality must be encouraged to improve our position in the fight against this disease and to protect human life.
In vitro anticoagulant activity of selected medicinal plants: potential interactions with warfarin and development of new anticoagulants
Authors: Leite Paula Mendonça , Freitas Aline , Amorim Juliana , Figueiredo Rita Carolina Duarte , Bertolucci Suzan , Faraco André , Martins Maria , Carvalho Maria G. , Castilho Rachel 
Published: July 2021

Abstract

Objectives
Warfarin is the most widely used anticoagulant in the world, but it has several limitations including its narrow therapeutic range, need for dose adjustment and high potential for interactions. The simultaneous use of other drugs or even medicinal plants and certain foods could interfere with its therapeutic activity. In this context, this study aims to investigate the in vitro anticoagulant potential and phytochemical constitution of 17 plants selected from a previous clinical cross-sectional study (2014), that investigated the habits of plant utilization among patients taking warfarin.

Methods
Ethanol extracts and essential oils were evaluated, in vitro, as to their effect in the prothrombin time (PT) and activated partial thromboplastin time (aPTT) tests. Four species that presented aPTT >50 s were selected for phytochemical evaluation.

Results
Thirteen of the 17 plants selected demonstrated a significant anticoagulant effect in at least one of the evaluated parameters. Citrus sinensis (PT=14.75 and aPTT=53.15), Mentha crispa (aPTT=51.25), Mikania laevigata (PT=14.90 and aPTT=52.10), and Nasturtium officinale (aPTT=50.55) showed greater anticoagulant potential compared to normal plasma pool (PT=12.25 and aPTT=37.73). Chemical profiles of these four species were obtained, and certain compounds were identified: rosmarinic acid from M. crispa and isoorientin from N. officinale.

Conclusions
Thus, the results of this study could be a useful indicator for clinical practice towards the possibility of interaction between these plants and anticoagulants, although further clinical research is needed taking into consideration the limitations of in vitro studies. These findings also suggest that further research into the action of these plants could be of real clinical value in identifying potential alternative anticoagulant therapies.