bluuebunny/crossref_metadata_2025_split huggingface dataset:
Аrterial stiffness and diastolic function of the left ventricle in patients with arterial hypertension and frailty
Authors: Fomina E. S. , Nikiforov V. S. 
Published: October 2021

Introduction. Increased arterial stiffness is one of the key links in the formation of cardiovascular pathology in older age groups. At the same time, the effect of vascular stiffness on myocardial function in cardiac patients with frailty remains insufficiently studied.Aim of study. Тo analyze the data of arterial stiffness and diastolic function of left ventricle (LV) in patients older than 65 years with arterial hypertension and frailty.Materials and methods. The study included 90 outpatient and inpatient patients older than 65 years with the presence of arterial hypertension. All patients were divided into two groups: with the presence and absence of frailty. To identify frailty, we used the questionnaire “Age is not a hindrance”, a short battery of physical activity tests. Methods of volumetric sphygmometry, echocardiography, including tissue Doppler were used. The obtained data were analyzed using a package of statistical programs.Results. The results of a comparative simultaneous non-randomized descriptive study of two groups of patients are presented. The study found that the systolic function, diastolic dysfunction of the left ventricle by the type of slowing down of LV relaxation in both groups did not significantly differ in their indicators. In the group of patients with frailty, LV diastolic dysfunction was significantly more often detected by the type of pseudonormalization – with an increase in filling pressure. When analyzing data of arterial stiffness, differences were obtained in both groups in the left cardio-ankle vascular index (LCAVI), systolic blood pressure (LB SAD), pulse pressure (LB PD) in the left shoulder area, and the delta of average blood pressure in the left ankle area (LA% IDA), which were significantly higher in patients with frailty.Conclusion. In the group of patients with hypertension older than 65 years with frailty, a violation of the LV diastolic function by the type of pseudonormalization with an increase in filling pressure prevails. An increase in filling pressure in the group of patients older than 65 years with hypertension and the presence of frailty is associated with an increase in the complex of indicators characterizing arterial stiffness – the cardio-ankle vascular index, systolic blood pressure, pulse pressure in the left shoulder area, the delta of average blood pressure in the left ankle area.
The thickness of the ventricles and interventricular septum in males with overweight according to echocardiography
Authors: Martirosyan L. P. , Balandina I. A. 
Published: October 2021

Introduction. Mortality from cardiovascular disease ranks first in the world. New and high requirements are required for the anatomical substantiation of emerging methods and methods of treatment. In modern literature, there are many publications on the issues of heart morphology, but data on the influence of gender, age, body weight on heart parameters are insufficient, fragmentary and often contradictory.Objective. To determine the thickness of the ventricles and interventricular septum in overweight men when performing echocardiography and to assess the presence or absence of the relationship of these parameters with age and body mass index (BMI) of the subjects. Patients and methods. The analysis of the protocols of ultrasound examination of the heart of 68 apparently healthy men of adolescence, the first and second periods of adulthood with a body mass index of 25.0–29.9 kg/m², with no pulmonary and cardiac pathology and the risk of cardiovascular diseases was carried out. Ultrasound examination was performed on an Aloka ProSound Alpha 6 ultrasound scanner. Results and discussion. When comparing the mean values of heart parameters in overweight men in three age groups according to the Kruskell – Wallis criterion, no statistically significant differences were found between the mean values (p > 0.05). Revealed a moderate strength relationship between the thickness of the anterior wall of the right ventricle with the age of the subject (r = 0.375; p = 0.020) and moderate strength relationship between the thickness of the posterior wall of the left ventricle and BMI (r = 0.352; p = 0.030).Conclusions. The results of the study supplement the information available in the scientific literature on the thickness of the ventricles of the heart and the interventricular septum in healthy men with overweight in three age groups. The data obtained will be useful to doctors of functional diagnostics when performing echocardiography in matters of differentiation between norm and pathology.
Features of atherosclerosis in carotid and coronary arteries
Authors: Konstantinova E. V. , Bogdanova A. A. , Sagatelyan A. A. , Kovaikin A. I. , Pershina E. S. , Gilyarov M. Yu. 
Published: October 2021

Atherothrombosis is a leading cause of myocardial infarction and ischemic atherothrombotic stroke. It represents a stage of atherosclerosis which is a pathologic process throughout the circulatory system. However, atherosclerosis has specific development characteristics in different vascular beds. Multiple factors contribute to atherosclerosis formation and progression such as genetic factors, vessel hemodynamics, and vessel anatomy. A better understanding of differences in vessels would improve prevention and treatment of atherosclerosis and its complication. In this article we review features of atherosclerosis in carotid and coronary vessels. We discuss specific conditions of local hemodynamics in the areas of bifurcation which promote atherosclerotic plaque progression, and review characteristics of unstable plaques in carotid and coronary vessels. We analyze immunologic and inflammatory processes, extracellular matrix degradation and remodeling, cellular apoptosis and autophagy occurring during atherosclerotic plaque destabilization as well as the possibility of diffuse plaque instability in systemic atherosclerosis. We review association and interaction of atherosclerotic processes in coronary and carotid arteries, and its significance for a patient. Improvement in understanding of atherosclerosis pathogenesis can lead to advances in atherosclerosis prevention. Timely and effective interventions would promote prevention of myocardial infarction and ischemic stroke which is highly important taking into account high mortality and morbidity rates.
8-year follow-up of a successful outcome of massive pulmonary embolism with cardiogenic shock
Authors: Semigolovskii N. Yu. , Mazurenko S. O. , Shabalina M. O. , Semigolovskii S. N. 
Published: October 2021

Currently pulmonary embolism (PE) is already on the 3rd place in terms of the frequency of occurrence among vascular diseases, and there is a global trend towards an increase in its frequency. PE is also considered as the most common cause of preventable death in the hospital. In the countries of Europe, Asia and the USA, there is a tendency to reduce the cases of fatal PE due to the use of more effective conservative therapy, invasive interventions and following the Recommendations. Since 2019, the European Guidelines for the diagnosis and treatment of PE have made the use of direct oral anticoagulants preferable in comparison with oral vitamin K antagonists.A case of massive PE in a 42-year-old patient developed in the specialized department of the hospital shortly after being transferred from the intensive care unit with verified PE of small branches (D-dimer, lung scintigraphy, Echo-cardiography) is presented. The debut of a massive PE in the form of a syncopal state with cardiogenic shock, required an urgent transfer of the patient to artificial lung ventilation, the use of vasopressors and systemic thrombolysis. During Echo-cardiography, a mobile blood clot was located in the right atrium. An emergency thrombectomy was performed from the pulmonary trunk and pulmonary arteries in conditions of artificial blood circulation, later a cava filter was installed. The features of anamnesis characteristic of PE (hormonal contraceptives), complaints (sudden shortness of breath, heaviness behind the sternum at admission) and concomitant pathology (drug-induced thyrotoxicosis) are analyzed.The results of the subsequent 8-year follow-up without relapses of PE are considered, the feature of which was the use of Rivaroxaban as an anticoagulant and angiovit (B vitamins – 6, 9 and 12) for the correction of hereditary hyperhomocysteinemia. Risk factors and modern standards of treatment of massive PE in the acute period and in the long term are discussed.
Effect of single and combined exposures to UV-C and UV-A LEDs on the inactivation of Klebsiella pneumoniae and Escherichia coli in water disinfection
Authors: Galezzo María-Angélica , Susa Manuel Rodríguez 
Published: October 2021

Abstract
A system consisting of one UV-A (365 nm) and two UV-C (265 nm) light-emitting diodes (LEDs) was built to evaluate the effect of single and combined exposures to UV-A and UV-C LEDs on Klebsiella pneumoniae and Escherichia coli inactivation and subsequent reactivation. The dose was measured by actinometry using potassium ferrioxalate. Of laboratory prepared samples, 10 mL were irradiated for 20, 30, 45, 60 and 90 s. Logarithmic inactivation and percentages of photoreactivation and dark repair were calculated. E. coli and K. pneumoniae were reduced by more than 7 and 4 logs, respectively, at a dose of 21.5 mJ cm−2 using UV-C. No positive synergistic effect on the inactivation of the two bacteria was observed when using a simultaneous combination of UV-C and UV-A, probably due to a reactivation of the bacteria in the presence of UV-A light, which was not observed in irradiated samples under an individual exposure of 265 nm. For E. coli under 265 nm, the percentage of photoreactivation amounted to 10%, 3 h after irradiation. The results of this study demonstrated the capacity to inactivate E. coli and K. pneumoniae up to a considerable level and provide information for the application of UV LEDs in point-of-use systems.
Effects of mixed irrigation using brackish water with different salinities and reclaimed water on a soil-crop system
Authors: Liu Chuncheng , Cui Bingjian , Hu Chao , Wu Haiqing , Gao Feng 
Published: October 2021

AbstractTo explore the effects of mixed irrigation on soil and crops, a pot experiment was conducted in two salinity levels of brackish water, four levels of mixed brackish-reclaimed water and freshwater irrigation as the control. The soil Na-Cl to Ca-SO4 contents changed, and activities of soil alkaline phosphatase and polyphenol oxidase changed, exhibiting a ‘V’-shaped curve with increasing the proportion of reclaimed water in the mixture. At the same brackish-reclaimed water level, there were no significant differences in alkaline phosphatase and polyphenol oxidase activities except for soil alkaline phosphatase activity decreasing significantly with the increase in salinity under brackish water irrigation. Mixed irrigation obviously improved superoxide dismutase activity but no significant influences on aboveground dry weight, underground biomass or crop physiological indexes (chlorophyll, soluble protein, malondialdehyde, peroxidase, catalase). Based on the integrated biological response index version 2 (IBRv2), the deviation of reclaimed water irrigation was the smallest, followed by 1:1 and 1:2 (3, 5 g/L brackish water salinities, respectively), with IBRv2 values of 7.94, 12.55 and 16.04. Therefore, considering the soil-crop characteristics, limited daily water amount and inadequate pipeline facilities for reclaimed water, the brackish-reclaimed water ratio should be 1:1 and 1:2 at 3, 5 g/L of brackish water, respectively.
Binary adsorption of [Pb(II) + Co(II)] from aqueous solution using thiolated saw dust
Authors: Dhiman Neha 
Published: October 2021

Abstract
Technology advancement has contributed to an increase in industrial activities, resulting in the introduction of metal ions into water resources at concentrations well above the WHO limits. Heavy metals are highly toxic and carcinogenic; they usually occur as multicomponent mixtures in the aquatic environment. In the present study, batch experiments have been conducted to study the dependence of varying concentration, time, pH and temperature on the uptake of Pb(II) as a pure component under equilibrium conditions using thiolated saw dust. Saw dust has been chemically modified with thioglycolic acid and characterised using proximate and FTIR analyses, the degree of thiolation has also been determined. To determine the effect of the presence of Co(II) ions on the uptake of Pb(II) ions, batch experiments for [Pb(II) + Co(II)] mixture have been carried out for concentration ratios of 1:0, 1:1, 1:2, 1:3, 1:4 of Pb:Co at pH 5 and data has been interpreted using Langmuir competitive isotherm, which shows that adsorption of Pb(II) has been suppressed by the presence of Co(II) ions in the binary solution, hence the adsorption process is antagonistic in nature. The study also indicates the possibility of simultaneous removal of both metal ions using low cost bioadsorbent, which is economical especially for application in small-scale industries.
Organocatalytic Synthesis and Antitumor Activity of Novel 1,2,3-triazoles
Derived from Fatty β-ketoesters
Authors: Seixas Fabiana K. , Alves Diego , Gomes Carolina B. , Corrêa Caroline L. , Cabrera Diego C. , D'Oca Marcelo G. M. , Ruiz Martha , Collares Tiago , Savegnago Lucielli 
Published: October 2021

Background:
Developing methods to synthesize highly functionalized and complex 1,2,3-triazoles from various combinations of substrates remains a significant challenge in organic synthesis. Thus, to the best of our knowledge, an organocatalytic approach to synthesize 1,2,3-triazoles derived from fatty acids has not been explored.

Objective:
In this sense, we describe here the organocatalyzed synthesis and preliminary results of antitumor and cytotoxic activity of a range of 1,2,3-triazoles derived from fatty esters.

Methods:
To synthesize 1,2,3-triazoles 3 derived from fatty β-ketoesters, we performed the reaction of appropriate aryl azides 2a-j with β-ketoesters 1a-c in the presence of 5 mol% of DBU using DMSO as a solvent at 70 °C for 24 h. The viability of 5637 cells was determined by measuring the reduction of soluble MTT to water-insoluble formazan. The IC50 concentration that inhibits 50% of cell growth and the results were obtained by at least three independent experiments in triplicate for each test.

Results:
Through enolate-mediated organocatalysis, 1,2,3-triazoles 3 derived from fatty β-ketoesters were synthesized in moderate to excellent yields by reacting fatty esters 1 with aryl azides 2 in the presence of a catalytic amount of 1,8-diazabicyclo[5.4.0]undec-7-ene (5 mol%). All compounds derived from palmitic acetoacetate 1a were evaluated regarding induced cytotoxicity in vitro in a human bladder cancer cell line, and compounds 3a, 3d, 3e, and 3g were shown to be promising alternatives for bladder cancer treatment and presented the lowest inhibitory concentration of IC50.

Conclusion:
We described a synthetic procedure to prepare 1,2,3-triazoles derived from fatty β-ketoesters by DBU-catalyzed 1,3-dipolar cycloaddition reactions of fatty esters with different aryl azides. Compounds derived from palmitic acetoacetate were screened for antitumor and cytotoxic activity in vitro in human bladder cancer cell lines, and compounds 3a, 3d, 3e, and 3g showed potential to treat bladder cancer.
The First Reported Case of Juvenile Dermatomyositis in an Adolescent with Down Syndrome and the Clinical Considerations for Therapy
Authors: Jones Jordan T. , Smith Chelsey 
Published: October 2021

Background:
Down Syndrome (DS) is one of the most common birth conditions in the United States of America, with approximately 5300 births annually, resulting in an estimated birth prevalence of 12.6 per 10,000 live births and a population prevalence in the USA since 2010 of 6.7 per 10,000 inhabitants. Children with DS have complex medical challenges that present due to changes in their immune system that results in increased rates of infection, malignancy, and autoimmune disease. Juvenile Dermatomyositis (JDM) is a rare, autoimmune disease, and the most common inflammatory myopathy of childhood. Reports suggest an increased incidence of arthritis in children with DS, but there have been no reports of JDM in children with DS. Additionally, those with DS pose unique challenges with an increase in adverse effects and ineffectiveness of immunosuppressive therapy.

Case :
We describe the first case of an adolescent female with DS who developed JDM with a positive anti-p155/140 antibody and characteristic clinical phenotype. We discuss increased awareness of autoimmune disease in adolescents with DS and clinical considerations for therapy with immunosuppression.

Conclusion:
Adolescents with DS are at increased risk for autoimmune disease, including JDM. Awareness, early recognition of the signs and symptoms of autoimmune disease in those with DS is important, so appropriate therapy can be implemented.
Efektivitas Senam Jantung Sehat dalam Menurunkan Tekanan Darah pada Lansia Hipertensi
Authors: Anggraini Dyah Annisa , Nadiyah Nadiyah , Jus'at Idrus , Nuzrina Rachmanida , Gifari Nazhif 
Published: October 2021

Hipertensi disebut sillent killer sebab merupakan penyakit mematikan serta dapat memicu terjadinya penyakit lain. Menurut Riskesdas (2018) prevalensi hipertensi di IndonesiaÂ mencapai 34,1%. Di antara upaya pencegahan non farmakologis pada lansia hipertensi adalah senam jantung sehat. Senam jantung sehat dapat membantu dalam penurunan tekanan darah. Tujuan dari penelitian ini yaitu untuk mengetahui efektivitas senam jantung sehat dalam menurunkan tekanan darah pada lansia hipertensi. Desain penelitian yang digunakan adalah quasi eksperimen. Sampel dalam penelitian ini merupakan pralansia dan lansia yang berjumlah 55 orang dan dibagi menjadi 2 kelompok. SebanyakÂ 30 orang responden dipilih sebagai kelompok intervensi dan 25 orang sisanya dipilih sebagai kelompok kontrol. Uji paired sample T test digunakan untuk melihat perbedaan dari tekanan darah sebelum dan sesudah intervensi. Penelitian ini telah mendapat persetujuan dari Komisi Etik Penelitian Universitas Esa Unggul. Untuk kelompok intervensi, hasil pengukuran tekanan darah sistolik sebelum dan setelah intervensi berturut-turut adalah 159,73 Â± 18,39 dan 130,00 Â± 20,01 (p <0.05). Sedangkan untuk tekanan darah diastolik berturut-turut adalah 92,47 Â± 10,97 dan 79,60 Â± 9,94 (p <0.05). Untuk hasil pengukuran pada kelompok kontrol yaitu tekanan darah sistolik menunjukkan 150,28 Â± 10,18 dan 144,40 Â± 7,54 (p <0.05) secara berturut â€“ turut. Sedangkan untuk tekanan darah diastolik menunjukkan 75,88 Â± 14,03 dan 80,40 Â± 2,00 (p <0.05) secara berturut â€“ turut. Dari hasil penelitian menunjukkan bahwa senam jantung sehat dapat menurunkan TDD dan TDS.
Examining the Trends in Online Health Information–Seeking Behavior About Chronic Obstructive Pulmonary Disease in Singapore: Analysis of Data From Google Trends and the Global Burden of Disease Study
Authors: Fang Yang , Shepherd Thomas A , Smith Helen E 
Published: October 2021

Background
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally, and timely health care seeking is imperative for its prevention, early detection, and management. While online health information–seeking behavior (OHISB) is increasingly popular due to widespread internet connectivity, little is known about how OHISB for COPD has changed in comparison with the COPD disease burden, particularly at a country-specific level.

Objective
This study aimed to examine the trends in OHISB for COPD and how that compared with the estimates of COPD disease burden in Singapore, a highly wired country with a steadily increasing COPD disease burden.

Methods
To examine the trends in OHISB for COPD, we performed Prais-Winsten regression analyses on monthly search volume data for COPD from January 2004 to June 2020 downloaded from Google Trends. We then conducted cross-correlational analyses to examine the relationship between annualized search volume on COPD topics and estimates of COPD morbidity and mortality reported in the Global Burden of Disease study from 2004 to 2017.

Results
From 2004 to 2020, the trend in COPD search volume was curvilinear (β=1.69, t194=6.64, P<.001), with a slope change around the end of 2006. There was a negative linear trend (β=–0.53, t33=–3.57, P=.001) from 2004 to 2006 and a positive linear trend (β=0.51, t159=7.43, P<.001) from 2007 to 2020. Cross-correlation analyses revealed positive associations between COPD search volume and COPD disease burden indicators: positive correlations between search volume and prevalence, incidence, years living with disability (YLD) at lag 0, and positive correlations between search volume and prevalence, YLD at lag 1.

Conclusions
Google search volume on COPD increased from 2007 to 2020; this trend correlated with the upward trajectory of several COPD morbidity estimates, suggesting increasing engagement in OHISB for COPD in Singapore. These findings underscore the importance of making high-quality, web-based information accessible to the public, particularly COPD patients and their carers.
ANALISIS PENGARUH ISLAMOPHOBIA TERHADAP KEBIJAKAN LUAR NEGERI AMERIKA SERIKAT DI PEMERINTAHAN DONALD TRUMP
Authors: Zulian Ibnu 
Published: October 2021

Semenjak Amerika Serikat dipimpin oleh pemerintahan Donald Trump kebijakan yang dibuat cukup kontroversial, karena abstrakan dan absurdan dalam memahami, berbicara, hingga membuat sebuah kebijakan yang berlandaskan pada isu Islamophobia. Donad Trump identik dengan wujud orkestra Islmophobia Amerika Saat ini, bukan tanpa alasan kebijakan pemindahan Duta Besar Amerika di Yesrusalem, pelarangan visa untuk negara-negara mayoritas Muslim dan pendataan warga negara Muslim di Amerika juga menjadi fenomena hangat baik tingkat nasional mau pun internasional. Dengan penelitian kualitatif diskriptif penulis menemukan adanya pengaruh Islampohobia dalam proses pembuatan kebijakan pemerintahan Donald Trump terhadap warga dan negara mayoritas Muslim. Penemuan ini dikuatkan dengan pendekatan teori kontruktivis yaitu segala sesuatu fenomena yang terjadi berdasarkan hasil kontruksi dengan berbagai kepentingan nasional dan aktor dibaliknya. Dengan adanya tulisan ini, kita bisa melihat indikasi dan tujuan dari kebijakan luar negeri Amerika Serikat saat ini, hingga yang akan datang.