bluuebunny/crossref_metadata_2025_split huggingface dataset:
Profiling of driver mutations in lung adenocarcinoma patients identifies rare compound EGFR mutations sensitive to second-generation EGFR-TKIs
Authors: Li Jun , Zhang Cuiyun , Guan Yuping , Wang Siyu , Zheng Jiawen , Feng Junnan , Han Sile , Ma Ruijuan , Ren Pengfei , Li Shasha , Groen Harry J. M. , Kok Klaas , van den Berg Anke , Wei Bing , Ma Jie , Li Hongle , Guo Yongjun 
Published: December 2024

Abstract
Background
Lung adenocarcinoma (LUAD) is the most predominant histological subtype of lung cancer characterized by driver mutations detected in a substantial proportion of the cases. Tyrosine kinase inhibitors (TKIs) are standard care for the patients with these mutations. In this study, we evaluated the efficiency of an NGS-based 8-gene test in selecting TKIs-sensitive patients in a cohort of treatment-naive Chinese LUAD patients and evaluated the sensitivity of rare compound mutations to different EGFR-TKIs in vitro.

Material and methods
Targeted sequencing covering the hotspot regions of eight LUAD driver genes was performed across 853 treatment-naive LUAD patients admitted in Henan Cancer Hospital (HNCH cohort). The mutational landscape of HNCH patients was compared with TCGA patients. Logistic regression analysis was used to determine the factors associated with presence of these mutations. Genetically modified LUAD PC9 cells were established to evaluate the sensitivity of selected EGFR rare compound mutations to different EGFR-TKIs.

Results
A total of 574 single nucleotide variants (SNVs), 270 indels, 88 amplifications, and 87 rearrangements were identified in this study, with EGFR and KRAS being the most frequently mutated genes. Females, mostly life-long non-smokers, had significantly higher EGFR mutation rates than males. Males, primarily smokers, more frequently had KRAS mutations. HNCH patients in general had a higher mutation count than TCGA patients (1.09 vs 0.93 mutations per patient (m/p)), in consistent with its higher proportion of patients with advanced disease. Rare EGFR compound mutations identified in this study, including Exon19del plus L747S/I744V and L858R plus V843I/T854A/G873, conferred genetically modified PC9 cells more sensitive to second-generation EGFR-TKI afatinib in-vivo.

Conclusion
This NGS-based 8-gene test efficiently identified over 70% of Chinese treatment-naive LUAD patients who are targetable for TKIs. Patients with rare EGFR compound mutations might consider second-generation EGFR-TKIs for treatment.
Framing climate risk: the role of local and international media in reporting on Japan’s omiwatari ice tradition
Authors: Fukumura Yoshimi 
Published: December 2024

AbstractThis study examines how local media in Japan report on the risks of climate change through the lens of a cultural tradition, focusing on the Shinto ritual of omiwatari in Nagano Prefecture. Omiwatari celebrates ice ridges on Lake Suwa that are believed to be the footprints of a local deity, but are increasingly threatened by warming winters. By analyzing online news articles from Japanese and international media, supplemented by fieldwork and interviews with local journalists, the research highlights contrasting media frames. International media emphasize the disappearance of the ice ridges as a symbol of global climate change, aiming to promote broader awareness and mitigation efforts. In contrast, Japanese national and local media focus their coverage on the observations of the shrine community and predict the formation of the ridges without framing these changes in the context of climate change. Despite this divergence, the resilience of omiwatari storytelling offers opportunities to adapt the tradition to changing environmental challenges, preserving cultural continuity even as its iconic ice ridges fade.
A mixed methods study of zootherapy practices and associated risks for zoonotic disease spillover in Rwanda
Authors: Hall Hayley , Majyambere Denis , Sibomana Eric , Uwase Shadia , Mahoro Janvier , Amuguni Hellen J. 
Published: December 2024

Abstract
Background
Zootherapy, the use of animals for human medicine and related cultural purposes, is an important component of traditional medicine, which is used by 80% of the global population. Human-animal interaction within zootherapy practices is a potential pathway for zoonotic disease spillover, and understanding these interactions is integral to the One Health approach. The objectives of this study were to assess and document zootherapy practices in Rwanda and identify sociocultural factors driving zootherapy use.

Methods
Using a mixed methods approach, 12 traditional healers were interviewed, 11 focus group discussions with community members were held, and 75 people were surveyed in 4 sectors of the Nyagatare District, Rwanda. Methods of preparation and administration of zootherapies were detailed and analyzed, highlighting methods that pose a risk for zoonotic transmission and calculating salience and fidelity levels. The demographic, educational, and cultural factors that shape human-animal interactions in Rwanda were evaluated via thematic analysis and chi-squared testing.

Results
This study identified 60 animal species used in zootherapy, including high-risk taxa for zoonoses, for a total of 336 zootherapeutic practices divided into 273 medical uses and 63 cultural uses. Of the survey participants, 57.1% reported the use of traditional medicine involving zootherapies, indicating that the general population partakes in self-treatment using animal parts/products. Cattle, the species identified as most salient by traditional healers, were used in the greatest number of zootherapies and were rated as the most important by focus group discussion participants. There is a significant relationship between sex and knowledge of zoonotic disease, with men more likely to declare knowledge of zoonotic disease (p = 0.0095). Preparation and administration methods are highly variable and generate diverse opportunities for zoonotic spillover. Across the survey and key informant populations, 85.1% indicated knowledge of zoonotic disease but nearly all participants had a desire to learn more about disease prevention.

Conclusions
Zootherapy use is a potential pathway for zoonotic spillover due to high-risk behaviors dictating usage. Interventions aimed at mitigating zoonoses should consider the risk of zootherapy practices and create policies that take into account sociocultural contexts.
Topical application of emu oil and menthol alleviates inflammation via modulation of NF-κB pathway in mouse model
Authors: Huang Jing , Yao Lan , Sun Jialin , Huang Ying , Chen Xi , Beng Liew Choong , Yang Xiao 
Published: December 2024

Abstract
Objective
The anti-inflammatory effects of emu oil and menthol as functional foods and topical medicinal formulations have been established both in vivo and through topical application. However, the mechanisms underlying their anti-inflammatory effects during in vitro transdermal application remain elusive. Thus, this study aimed to evaluate the anti-inflammatory effects of a composite cream enriched with emu oil and menthol in a mouse ear swelling model and investigate its mechanisms underlying the local anti-inflammatory actions.

Methods
The xylene-induced ear swelling model was utilized to evaluate the topical anti-inflammatory efficacy of the composite cream. Histopathological assessments of ear tissue were conducted using hematoxylin and eosin staining. Additionally, real-time quantitative PCR was performed to quantify the mRNA levels of NF-κB, IL-6, and IL-1β in ear tissues. Lastly, immunohistochemistry staining was performed to measure the protein expression levels of NF-κB p65 and IL-6.

Results
The application of the composite cream effectively alleviated ear swelling elicited by xylene exposure. Moreover, it relieved ear tissue edema and microvascular bleeding induced by xylene and reversed alterations in the mRNA and protein expression levels of NF-κB and IL-6 in the same tissues. Additionally, emu oil and menthol exerted anti-inflammatory effects in mice, mitigating xylene-induced ear inflammation and exhibiting a synergy between these two.

Conclusions
The composite cream may serve as a promising topical formulation for alleviating localized inflammation, which is associated with the modulation of NF-κB pathway. Additionally, emu oil and menthol can be used as active anti-inflammatory ingredients in cosmetic formulations.
Precision autofocus in optical microscopy with liquid lenses controlled by deep reinforcement learning
Authors: Zhang Jing , Fu Yong-feng , Shen Hao , Liu Quan , Sun Li-ning , Chen Li-guo 
Published: December 2024

AbstractMicroscopic imaging is a critical tool in scientific research, biomedical studies, and engineering applications, with an urgent need for system miniaturization and rapid, precision autofocus techniques. However, traditional microscopes and autofocus methods face hardware limitations and slow software speeds in achieving this goal. In response, this paper proposes the implementation of an adaptive Liquid Lens Microscope System utilizing Deep Reinforcement Learning-based Autofocus (DRLAF). The proposed study employs a custom-made liquid lens with a rapid zoom response, which is treated as an “agent.” Raw images are utilized as the “state”, with voltage adjustments representing the “actions.” Deep reinforcement learning is employed to learn the focusing strategy directly from captured images, achieving end-to-end autofocus. In contrast to methodologies that rely exclusively on sharpness assessment as a model’s labels or inputs, our approach involved the development of a targeted reward function, which has proven to markedly enhance the performance in microscope autofocus tasks. We explored various action group design methods and improved the microscope autofocus speed to an average of 3.15 time steps. Additionally, parallel “state” dataset lists with random sampling training are proposed which enhances the model’s adaptability to unknown samples, thereby improving its generalization capability. The experimental results demonstrate that the proposed liquid lens microscope with DRLAF exhibits high robustness, achieving a 79% increase in speed compared to traditional search algorithms, a 97.2% success rate, and enhanced generalization compared to other deep learning methods.
Putting piezoelectric sensors into Fano resonances
Authors: Wang Mengting , Huang Jianqiu , Huang Qing-An 
Published: December 2024

AbstractPiezoelectric resonance sensors are essential to many diverse applications associated with chemical and biological sensing. In general, they rely on continuously detecting the resonant frequency shift of piezoelectric resonators due to analytes accreting on their surfaces in vacuum, gas or fluid. Resolving the small analyte changes requires the resonators with a high quality factor. Here, we propose theoretically and demonstrate experimentally a scheme using a physics concept, i.e., a Fano resonance, to enhance the quality factor rather than optimizing the structure and material of the resonator itself though these are important. The Fano resonance arises due to the interference between a discrete mode and a continuum of modes, leading to the asymmetric and steep dispersion. In our scheme, the as-fabricated piezoelectric sensors are put into the Fano resonance by connecting an external shunt capacitor to them. As a verification case, one-port surface acoustic wave (SAW) resonators on LiNbO3 substrate, incorporating a composite of polymethyl methacrylate (PMMA) and graphene oxide (GO) for humidity sensing, have been fabricated and characterized. We enhance the quality factor by up to a factor of about 8, from 929 for the as-fabricated sensor to 7682 for that with the external shunt capacitor. Our results pave the way for the practical development of piezoelectric resonance sensors with high quality factor.
Planetary migration in wind-fed non-stationary accretion disks in binary systems
Authors: Nekrasov A. D. , Zhuravlev V. V. , Popov S. B. 
Published: December 2024

Context. An accretion disk can be formed around a secondary star in a binary system when the primary companion leaves the main sequence and starts to lose mass at an enhanced rate.
Aims. We study the accretion disk evolution and planetary migration in wide binaries.
Methods. We used a numerical model of a non-stationary alpha disk with a variable mass inflow. We took into account that the low- mass disk has an extended region that is optically thin along the rotation axis. We considered irradiation by both the host star and the donor. The migration path of a planet in such a disk is determined by the migration rate varying during the disk evolution.
Results. Giant planets may open and close the density gap several times over the disk lifetime. We identify a new type of migration specific to parts of the growing disk with a considerable radial gradient of an aspect ratio. Its rate is enclosed between the type II and the fast type I migration rates determined by the ratio of time and radial derivatives of the disk aspect ratio. Rapid growth of the wind rate just before the envelope loss by the donor leads to the formation of a zone of decretion, which may lead to substantial outward migration. In binaries with an initial separation of a ≲ 100 AU, migration becomes most efficient for planets with 60–80 Earth masses. This results in approaching the distance from the host star, where the tidal forces become non-negligible. Less massive Neptune-like planets at the initial orbits rp ≲ 2 AU can reach these internal parts in binaries with a ≲ 30 AU.
Conclusions. In binaries, mass loss by the primary component at late evolutionary stages can significantly modify the structure of a planetary system around the secondary component, resulting in mergers of relatively massive planets with a host star.
Retraction Note: The Role of Customer Relationship Management to Strengthen Customer Satisfaction Using Product Innovation and Customer Value as Intervening Variable
Authors: Dananjoyo Radyan , Udin Udin , Wibowo Annisa Ayuningtyas 
Published: December 2024

The authors report an unintentional error in publishing an incorrect version of their article in ICTCED 2024 when another final version was already published online. The authors sincerely apologize for any inconvenience this careless conduct might have caused to the journal.
Request approved by the proceedings Editors and the Publisher on October 28, 2024.
Tout dire
Authors: Avrane Patrick 
Published: December 2024

La psychanalyse avec les enfants demande une adaptation de la technique analytique. Certaines règles appliquées abruptement peuvent empêcher la compréhension de l’origine du symptôme. C’est le cas ici quand une exigence de « tout dire » ne permit pas à une cure de s’engager, mais au contraire, a fait le jeu de la résistance. Une parole ne tenant pas compte d’une possibilité d’inscription dans un temps du transfert, introduit de la confusion. C’est au psychanalyste de repérer dans le transfert le moment où il peut dire. Il le sait de sa propre expérience.
Dans l’absence des mots, un enfant donne à voir
Authors: Matha Catherine 
Published: December 2024

En quoi le dispositif de la consultation thérapeutique, et les limites qu’il comprend, peut s’avérer propice au passage d’un état à l’autre, du voir au dire, du dire au parler ? C’est cette interrogation que cet article se propose de mettre au travail à partir de moments cliniques choisis et extraits des trois premières consultations avec un jeune enfant et ses parents.
Du fait de sa spécificité, la consultation thérapeutique avec un jeune enfant permet l’actualisation des courants pulsionnels, des fantasmes et des différents régimes d’angoisse qui traversent les liens parents-enfant. La prise en compte du langage de l’enfant, dans toutes ses formes expressives, pris dans la dynamique associative des échanges avec les parents, et l’attention de l’analyste portée à ses propres mouvements transférentiels, permettent la confrontation à la présence actuelle de ce qui tente de se traiter, de ce qui était sans parole, dans l’actualité de l’évènement et de l’inédit de temps confondus.
Dans la situation présentée, la temporalité d’une séance à l’autre, entre attentes et résistances de la famille, montre l’advenue possible d’une rencontre entre l’infans de l’enfant et celui de la mère, autour du fantasme de l’enfant mort, venant éclairer autrement le symptôme d’appel : des troubles importants du sommeil.
Is Pregnancy a Risk Factor for Progression of Diabetic Retinopathy and Nephropathy in Type 1 Diabetes? A Matched Cohort Study
Authors: Mimouni Francis , Khoury Jane C. , Ehrlich Shelley , Sheffer-Mimouni Galit , Rosenn Barak , Miodovnik Menachem 
Published: December 2024

Objective This study aimed to test the hypothesis that the development or deterioration of nephropathy and retinopathy over time is not affected by pregnancy in women with pregestational type 1 diabetes mellitus (T1DM).
Study design Prospective, observational study of nephropathy and retinopathy follow-up during pregnancy and in a subsequent period of 2 years in a group of pregnant women with T1DM (study group) that we compared with pair-matched non-pregnant women with T1DM (control group) who underwent similar intensive follow-up.
Results The rate of renal microvascular complications was similar at entry, 17.4% (4/23) in the study group and 21.7% (5/23) in the control group. At the last visit, both groups had nephropathy rates of 17.4% (4/23) and paired p-value of 1.00. Similarly, the rate of retinal microvascular complications of any grade was similar in both groups and remained so at the last follow-up examination.
Conclusion Pregnancy per se does not appear to increase the risk for the development of, or the acceleration of the progression of retinopathy and nephropathy during a follow-up of at least 2 years in relatively healthy T1DM patients. This information is important for counseling young women with T1DM who are considering becoming pregnant.
Key Points
In Defense of Desflurane: Is There a Specific Role for Desflurane in Neuroanesthesia?
Authors: Joshi Shailendra , Joshi Vidur 
Published: December 2024

AbstractIt is challenging to counter the widespread criticism of desflurane as the volatile anesthetic agent with the most significant greenhouse gas effect, one which is likely to exacerbate global warming. In 2022, the journal “Anaesthesia” published guidelines for minimizing the impact of anesthetic gases on global warming, which the anesthetic community has largely embraced. One of its recommendations was the removal of desflurane from drug formularies. However, this review underlines the likely benefits of desflurane in the context of actual and potential neurological injuries. With an estimated 13.8 million neurosurgical operations performed annually, desflurane could offer advantages to some of these patients. Therefore, it is imperative to develop an environmentally safe approach for its use rather than remove it from formularies. We discuss desflurane's environmental impact, its unique anesthetic and chemical properties, and its specific application in neuroanesthesia practice. Based on existing evidence, we argue that desflurane could hasten the wake-up of neurosurgical patients. We propose switching to desflurane toward the end of surgery for patients at risk of, or with, neurological injuries. Predictable, early, and monitorable wake-up in these cases could prevent surgical delays, avoid additional investigations, or enable early detection of new deficits. Instead of a blanket ban, desflurane's use should be investigated—systematically and carefully. With education, well-defined indications, limited use, intelligent vaporizers, scavenging, and recycling systems, the use of desflurane could be justified under specific circumstances. Moreover, the problem of environmental damage from inhaled anesthetics must be comprehensively evaluated. Minimizing the use of desflurane is a positive step to protect the environment, but anesthesiologists should enforce other measures to protect the environment with equal urgency.
Anesthesia in PET/MRI. Challenges for the Anesthesiologist: A Narrative Review
Authors: Venkataramaiah Sudhir , Venkatapura Ramesh J. , Nagaraj Chandana 
Published: December 2024

AbstractPositron emission tomography magnetic resonance imaging (PET/MRI) is an advanced imaging modality that combines metabolic information obtained from PET with anatomical and functional details obtained from MRI. This hybrid imaging technique offers superior spatial and temporal resolutions, making it invaluable in clinical and research settings. This review explores the considerations and strategies for administering anesthesia during PET/MRI procedures. Key aspects include patient immobilization to minimize motion artifacts, optimization of anesthetic agents and techniques, and maintenance of physiological stability throughout the imaging session. The review also addresses specific physiological and anesthetic necessities that may influence or interfere with the effective functioning of the injected radiotracer. Apart from strategies and protocols that can be adapted for the safe delivery of anesthesia, this review highlights vital aspects of radiation safety for anesthesiologists working in PET/MRI.
Analysis and experiment of conductive rod of high voltage casing considering creep condition
Authors: Zhou Xiu , Tian Tian , Li Liang , Bai Jin , Luo Yan , Ma Kui , Zhang Heng , Jiang Kaiji , Chen Dezhi 
Published: December 2024

Transformer bushings are used in large quantities in substations, and their operational reliability directly affects the operational safety of equipment and the power grid. The conductor rod is a crucial component of a high-voltage (HV) casing, and any breakage can trigger line protection actions and lead to significant economic losses. Since the conductive rod is subjected to the tension exerted by the compression spring for a long time and the influence of other external tensions, it is in a state of slow creep, and thus the conductive rod gradually fails. Therefore, this paper investigates the stress and deformation of the conductor rod in a 750 kV HV casing under service conditions that take creep characteristics into account. First, a finite element model of the rod connector considering creep characteristics is established. Second, stress and deformation experiments of the sample are carried out, considering the effect of creep characteristics. Finally, the experimental results are compared with the simulation results to verify the accuracy of the simulation.