bluuebunny/crossref_metadata_2025_split huggingface dataset:
Momentum transfer driven by fluctuations in relativistic counter-propagating electron beams
Authors: Ghizzo A , Del Sarto D 
Published: February 2021

Abstract
A semi-Lagrangian relativistic Vlasov–Maxwell solver is used to describe the non-linear momentum transfer between electron beams, which is driven by spontaneous fluctuations in the oblique filamentation instability (a type of Weibel mode) in two-dimensional plasmas. For counter-streaming plasmas, these filamentation instabilities may strengthen the generation of a fine structure of the distribution function in phase space. Properties of such counter-streaming beams are investigated using full-kinetic simulations and a Hamiltonian reduction technique based on the invariance of the transverse canonical momentum, the so-called multi-stream model. In the regime where

k

d

e

≫
1

,

k

being the wavevector and d

e
the electron skin depth, a momentum transfer takes place when a mesoscale current filamentation mode couples with microscopic phase-space fluctuations. This regime is characterized by the appearance of filamentation modes with large wavenumbers and large amplitude fluctuations, which induce variations of the L
2-norm of the plasma in link with the self-organization of counter-streaming electron beams. We also discuss some theoretical aspects of information theory that highlight the role of the (reversible) entropy production in momentum transfer, thus by clarifying the connections between (microscopic) fluctuations of the distribution function and the fundamental aspects of the filamentation in Vlasov theory. The momentum transfer between beams is quantitatively analyzed by means of both theoretical estimations and numerical experiments.
Scattering in the Ising model with the quantum Lanczos algorithm
*
Authors: Yeter-Aydeniz Kübra , Siopsis George , Pooser Raphael C 
Published: February 2021

Abstract
Time evolution and scattering simulation in phenomenological models are of great interest for testing and validating the potential for near-term quantum computers to simulate quantum field theories. Here, we simulate one-particle propagation and two-particle scattering in the one-dimensional transverse Ising model for 3 and 4 spatial sites with periodic boundary conditions on a quantum computer. We use the quantum Lanczos algorithm to obtain all energy levels and corresponding eigenstates of the system. We simplify the quantum computation by taking advantage of the symmetries of the system. These results enable us to compute one- and two-particle transition amplitudes, particle numbers for spatial sites, and the transverse magnetization as functions of time. The quantum circuits were executed on various IBM Q superconducting hardware. The experimental results are in very good agreement with the values obtained using exact diagonalization.
Creep properties and microstructure of a Mg-6Al-1Nd-1.5Gd alloy at temperatures above 150 °C
Authors: Wang Wuxiao , Liu Jian , Wang Na , Qin Zihe , Qin Shaoyong , Guan Shuwen 
Published: February 2021

Abstract
Compressive creep behavior of a Mg-Al alloy containing a small amount of Nd and Gd (Mg-6Al-1Nd-1.5Gd) was investigated at temperatures from 150 °C to 200 °C under a constant applied stress of 90 MPa, and its microstructure before and after creep testing was compared. Results showed that steady-state creep rate of the alloy was only 1.946 × 10−8 /s at 150 °C, and was increased by four times and almost one order of magnitude at 175 °C and 200 °C, respectively. The microstructure of the alloy mainly consists of α-Mg, β-Mg17Al12 phases, and Al2RE phases, which were distributed both in dendrites of α-Mg and at grain boundaries originally. After creep for 120 h, more Al2RE phases were aggregated at grain boundaries. The continuous β-Mg17Al12 phase turned into dispersed dot-like or blocky particles. As the test temperature increased, the number of dislocation lines gradually increased due to the increase of creep strain. Meanwhile, dislocation tangle and dislocation pile-ups occurred near grain boundaries. However, obvious slip traces and slip lines appeared inside α-Mg dendrites at 175 °C and 200 °C, respectively, indicating that 〈c + a〉 non-basal slip system was activated, creep resistance decreased dramatically.
Diagnostic software proposal for bone scan follow-up using false color based on the gammagrams analysis from gray tone histograms
Authors: Jaramillo Núñez Alberto , Arriaga Hernández Jesús Alonso , Cuevas Otahola Bolivia , Pérez Meza Mónica , Sánchez Rinza Bárbara 
Published: February 2021

Abstract
In this work we introduce a technique to speed up the interpretation of bone scans with the aim of determining the presence or absence of metastatic disease. We use gray tone histograms, resembling the use of band-pass filters, in order to ensure a reliable interpretation of the bone scan, therefore providing an accurate diagnosis. We draw particular attention to three cases. The first case corresponds to shifted histograms. If the histogram is shifted toward the origin, the bone scan is free of metastasis. If it is shifted to the right and slightly broadened, this indicates the presence of a bone scan anomaly other than metastasis. On the other hand, if the histogram is broadened and shifted to the left, this suggests the presence of metastatic disease. The second case corresponds to a histogram with noticeable fluctuations, indicating the presence of metastasis. Such fluctuations could become local maxima peaks, indicating the advance of the metastasis. The third case corresponds to the false color results, displayed in terms of the gray tones, observed in the histogram. Such false color is assigned from the construction of a 7-color palette and is selected in terms of the gray tones range. This eases the ad hoc false color assignation for visualization purposes. The final diagnosis is carried out in terms of the color, geometry, extension, and location of the region of interest in the images. Our proposed technique has the potential to be used in high-demand oncology centers due to its simplicity and diagnostic efficiency, confirmed and tested by specialists in the Centro Medico Siglo XXI (XXI Century Medical Center), CDMX-México.
Space survivability for printed electronics applications
Authors: Ouchen Fahima , Aga Roberto , Harvey Malia , Heckman Emily 
Published: February 2021

Abstract
The effects of atomic oxygen (AO) in low earth orbit and the physical effects of space launch on printed materials were studied for aerosol-jet printed Au and Ag through a 6 month exposure period on the Materials International Space Station Experiment (MISSE). RF and DC test platforms were designed for two printed electronics-compatible substrates (Rogers CLTE-XT and Ferro L8) to assess the amount of degradation caused by AO exposure in space. A passivation layer of CORIN-XLS applied over the printed metal traces was also studied for its effectiveness. Both bare and passivated test structures of printed Ag and Au traces were exposed to low earth orbit on the 10th MISSE mission. The effects of AO and the 6 month space exposure on the samples are reported here.
Asymmetrical reproductive barriers in sympatric jewelflowers: are floral isolation, genetic incompatibilities and floral trait displacement connected?
Authors: Christie Kyle , Doan Jonathan P , Mcbride Wendy C , Strauss Sharon Y 
Published: February 2021

AbstractFloral visitors influence reproductive interactions among sympatric plant species, either by facilitating assortative mating and contributing to reproductive isolation, or by promoting heterospecific pollen transfer, potentially leading to reproductive interference or hybridization. We assessed preference and constancy of floral visitors on two co-occurring jewelflowers [Streptanthus breweri and Streptanthus hesperidis (Brassicaceae)] using field arrays, and quantified two floral rewards potentially important to foraging choice – pollen production and nectar sugar concentration – in a greenhouse common garden. Floral visitors made an abundance of conspecific transitions between S. breweri individuals, which thus experienced minimal opportunities for heterospecific pollen transfer from S. hesperidis. In contrast, behavioural isolation for S. hesperidis was essentially absent due to pollinator inconstancy. This pattern emerged across multiple biotic environments and was unrelated to local density dependence. S. breweri populations that were sympatric with S. hesperidis had higher nectar sugar concentrations than their sympatric congeners, as well as allopatric conspecifics. Previous work shows that S. breweri suffers a greater cost to hybridization than S. hesperidis, and here we find that it also shows asymmetrical floral isolation and floral trait displacement in sympatry. These findings suggest that trait divergence may reduce negative reproductive interactions between sympatric but genetically incompatible relatives.
The evolving role of MUC16 (CA125) in the transformation of ovarian cells and the progression of neoplasia
Authors: Giamougiannis Panagiotis , Martin-Hirsch Pierre L , Martin Francis L 
Published: February 2021

AbstractMUC16 (the cancer antigen CA125) is the most commonly used serum biomarker in epithelial ovarian cancer, with increasing levels reflecting disease progression. It is a transmembrane glycoprotein with multiple isoforms, undergoing significant changes through the metastatic process. Aberrant glycosylation and cleavage with overexpression of a small membrane-bound fragment consist MUC16-related mechanisms that enhance malignant potential. Even MUC16 knockdown can induce an aggressive phenotype but can also increase susceptibility to chemotherapy. Variable MUC16 functions help ovarian cancer cells avoid immune cytotoxicity, survive inside ascites and form metastases. This review provides a comprehensive insight into MUC16 transformations and interactions, with description of activated oncogenic signalling pathways, and adds new elements on the role of its differential glycosylation. By following the journey of the molecule from pre-malignant states to advanced stages of disease it demonstrates its behaviour, in relation to the phenotypic shifts and progression of ovarian cancer. Additionally, it presents proposed differences of MUC16 structure in normal/benign conditions and epithelial ovarian malignancy.
Effective Human Immunodeficiency Virus Molecular Surveillance Requires Identification of Incident Cases of Infection
Authors: Little Susan J , Chen Tom , Wang Rui , Anderson Christy , Pond Sergei Kosakovsky , Nakazawa Masato , Mathews William C , DeGruttola Victor , Smith Davey M 
Published: February 2021

Abstract

Background
Ending the human immunodeficiency virus (HIV) epidemic requires knowledge of key drivers of spread of HIV infection.

Methods
Between 1996 and 2018, 1119 newly and previously diagnosed, therapy-naive persons with HIV (PWH) from San Diego were followed. A genetic distance–based network was inferred using pol sequences, and genetic clusters grew over time through linkage of sequences from newly observed infections. Cox proportional hazards models were used to identify factors associated with the rate of growth. These results were used to predict the impact of a hypothetical intervention targeting PWH with incident infection. Comparison was made to the Centers for Disease Control and Prevention (CDC) Ending the HIV Epidemic (EHE) molecular surveillance strategy, which prioritizes clusters recently linked to all new HIV diagnoses and does not incorporate data on incident infections.

Results
Overall, 219 genetic linkages to incident infections were identified over a median follow-up of 8.8 years. Incident cluster growth was strongly associated with proportion of PWH in the cluster who themselves had incident infection (hazard ratio, 44.09 [95% confidence interval, 17.09–113.78]). The CDC EHE molecular surveillance strategy identified 11 linkages to incident infections a genetic distance threshold of 0.5%, and 24 linkages at 1.5%.

Conclusions
Over the past 2 decades, incident infections drove incident HIV cluster growth in San Diego. The current CDC EHE molecular detection and response strategy would not have identified most transmission events arising from those with incident infection in San Diego. Molecular surveillance that includes detection of incident cases will provide a more effective strategy for EHE.
Doxycycline Versus Azithromycin for the Treatment of Rectal Chlamydia in Men Who Have Sex With Men: A Randomized Controlled Trial
Authors: Dombrowski Julia C , Wierzbicki Michael R , Newman Lori M , Powell Jonathan A , Miller Ashley , Dithmer Dwyn , Soge Olusegun O , Mayer Kenneth H 
Published: February 2021

Abstract

Background
Azithromycin and doxycycline are both recommended treatments for rectal Chlamydia trachomatis (CT) infection, but observational studies suggest that doxycycline may be more effective.

Methods
This randomized, double-blind, placebo-controlled trial compared azithromycin (single 1-g dose) versus doxycycline (100 mg twice daily for 7 days) for the treatment of rectal CT in men who have sex with men (MSM) in Seattle and Boston. Participants were enrolled after a diagnosis of rectal CT in clinical care and underwent repeated collection of rectal swabs for nucleic acid amplification testing (NAAT) at study enrollment and 2 weeks and 4 weeks postenrollment. The primary outcome was microbiologic cure (CT-negative NAAT) at 4 weeks. The complete case (CC) population included participants with a CT-positive NAAT at enrollment and a follow-up NAAT result; the intention-to-treat (ITT) population included all randomized participants.

Results
Among 177 participants enrolled, 135 (76%) met CC population criteria for the 4-week follow-up visit. Thirty-three participants (19%) were excluded because the CT NAAT repeated at enrollment was negative. Microbiologic cure was higher with doxycycline than azithromycin in both the CC population (100% [70 of 70] vs 74% [48 of 65]; absolute difference, 26%; 95% confidence interval [CI], 16–36%; P &lt; .001) and the ITT population (91% [80 of 88] vs 71% [63 of 89]; absolute difference, 20%; 95% CI, 9–31%; P &lt; .001).

Conclusions
A 1-week course of doxycycline was significantly more effective than a single dose of azithromycin for the treatment of rectal CT in MSM.

Clinical Trials Registration
NCT03608774.
Computational investigation of heat energy interaction for a residential building with a normal clay brick and sinicon brick
Authors: Kummitha Obula Reddy , Kumar R Vijay 
Published: February 2021

AbstractMost of the building energy is mainly contributing to the achievement of thermal comfort. The cooling load on air conditioners will increase with increased heat transfer into the building from the surroundings. The amount of heat transfer into the building mainly depends on building materials used in construction. In this research, an attempt has been made to analyse the self-sufficient homes’ concept by visualizing variation in heat transfer of the building concerning ordinary clay brick and brick with sinicon composition. The temperature distribution of airflow, time lag, decrement factor, and comfort conditions are investigated concerning these materials with computational fluid dynamics. Numerical modeling has been defined by selecting three-dimensional fluid flow governing equations and the k–ε turbulence model. All the fluid flow governing equations have been solved with the finite-volume second-order upwind discretization and SIMPLE algorithm for pressure–velocity coupling. Numerical results have been analysed for both the materials and we identified that the sinicon brick material for the considered wall thickness (9 inches) had registered an increased time lag (∼2 hrs) and a decreased decrement factor (0.05). This research investigation shows that the sinicon-brick wall strongly decreases heat transfer through it compared to the normal-red brick wall. The sinicon brick significantly reduces the air conditioner’s cooling load by decreasing heat energy penetration into the building.
The Introductive Baka/Bāki in Rural Palestinian Arabic
Authors: Shachmon Ori , Marmorstein Michal 
Published: February 2021

Abstract
The article explores the structure and use of the existential verb baka in Rural Palestinian Arabic for the introduction of orientation sections and fragments in narrative discourse. In clause-initial position the existential verb presents a non-inflecting form, either the 3MSG perfect baka or the MSG active participle bāki. We argue that the noninflectability of baka and bāki is indicative of their syntactic detached-ness from the following unit and is explained by their discourse-disjunctive function. We show that the existential baka/bāki serves to introduce both narrative-initial and narrative-embedded orientation. It may initiate utterances containing simple nominals or whole clauses. The distribution of the specific patterns is determined, inter alia, by the genre of the narrative told. Finally, we propose that the preference of the participle bāki over baka in folktales and in less committed instances of personal narratives may be related to the evidential function of the active participle in the dialects under examination.
MicroRNA319a regulates plant resistance to Sclerotinia stem rot
Authors: Dong Weiguo , Ren Wenqing , Wang Xuan , Mao Yanfei , He Yuke 
Published: February 2021

Abstract
MicroRNA319a (miR319a) controls cell division arrest in plant leaves by inhibiting the expression of TCP (TEOSINTE BRANCHED 1/CYCLOIDEA/PCF) family genes. However, it is unclear whether miR319a influences infection by necrotrophic pathogens and host susceptibility. In this study, we revealed that miR319a affects plant resistance to stem rot disease caused by Sclerotinia sclerotiorum. In Brassica rapa plants infected with S. sclerotiorum, miR319a levels increased while the expression levels of several BraTCP genes significantly decreased compared with those of uninfected plants. Overexpression of BraMIR319a in B. rapa increased the susceptibility of the plants to S. sclerotiorum and aggravated stem rot disease, whereas overexpression of BraTCP4-1 promoted plant resistance. RNA sequencing data revealed a potential relationship between miR319a and pathogen-related WRKY genes. Chromatin immunoprecipitation, electrophoretic mobility shift, and reporter transaction assays showed that BraTCP4-1 could bind to the promoters of WRKY75, WRKY70, and WRKY33 and directly activate these pathogen-related genes. Moreover, the expression levels of WRKY75, WRKY70, and WRKY33 in plants overexpressing BraMIR319a decreased significantly, whereas those of plants overexpressing BraTCP4-1 increased significantly, relative to the wild type. These results suggest that miR319a and its target gene BraTCP4 control stem rot resistance through pathways of WRKY genes.
Topic modelling on archive documents from the 1970s: global policies on refugees
Authors: Grant Philip , Sebastian Ratan , Allassonnière-Tang Marc , Cosemans Sara 
Published: February 2021

Abstract
This study conducts a historical analysis of global policies on refugees within typewritten and digitally born documents (c. 55,000 pages) from international and national archives. The data originate from the 1970s and are stored in archives from the UK and US governments, plus the United Nations High Commissioner for Refugees (UNHCR). The overarching theme is to analyse the involvement of the UK, the USA, and the UNHCR in different refugee cases that occurred during the 1970s. To do so, we (1) identify the main topics in each document; (2) investigate the transmission of topics horizontally (between organizations) and vertically (through time); and (3) suggest targeted areas of the document set for further close reading by historians. Standard Optical Character Recognition and object detection are used to extract information from documents and categorize them. Then, natural language processing (NLP) methods like topic modelling and clustering are used to identify topics and the relationships between them across time. The results identify several main themes covered by different organizations and how the focus of each organization changes diachronically. Besides its academic contribution, this study also demonstrates how, through the use of existing techniques with limited customization, digital technologies in the hands of the historian can augment and complement qualitative methods in bringing to light the themes and trends demonstrated in large bodies of historical documents.
Extension for Community Healthcare Outcomes (ECHO) Telementoring in the Military: Where We Are Now, Opportunities and Challenges
Authors: Katzman Joanna , Tomedi Laura , Swift Robin , Castillo Erick , Morrow Connie , Lutz Laurie , Galloway Kevin T , McCoy-Stafford Kimberly , Klein Zachary , Turner Greg , Beckman Darrick J , Terrell Jennifer , Forde Shannon , Martin Chamron , Morgan Sharon 
Published: February 2021

ABSTRACT

Introduction
In collaboration with the ECHO (Extension for Community Healthcare Outcomes) Institute since 2012, the Army, Navy, and Air Force have developed medical teleECHO programs to address various health and safety issues affecting military personnel. This article describes and compares the current state of military teleECHOs as well as the growth and change over time.

Materials and Methods
This study evaluated continuing education units (CEUs) offered, average session attendance, and number of spoke sites for current military teleECHO programs across the service branches.

Results
Between 2012 and 2019, the military teleECHO initiative grew from one program to seven different teleECHO programs, covering topics from pain to diabetes to amputee care. Military ECHOs now provide training to 10 countries and 27 states in the United States. Between October 2018 and September 2019, the military ECHO programs provided a total of 51,769 continuing medical education (CME) hours to a total of 3,575 attendees from 223 spoke sites.

Conclusions
The military has successfully used the ECHO model to improve the health and safety of active-duty military, retirees, and dependents.
Application of counter-selectable marker PIGA in engineering designer deletion cell lines and characterization of CRISPR deletion efficiency
Authors: Li Donghui , Sun Xiaoji , Yu Fangzhou , Perle Mary Ann , Araten David , Boeke Jef D 
Published: February 2021

Abstract
The CRISPR/Cas9 system is a technology for genome engineering, which has been applied to indel mutations in genes as well as targeted gene deletion and replacement. Here, we describe paired gRNA deletions along the PIGA locus on the human X chromosome ranging from 17 kb to 2 Mb. We found no compelling linear correlation between deletion size and the deletion efficiency, and there is no substantial impact of topologically associating domains on deletion frequency. Using this precise deletion technique, we have engineered a series of designer deletion cell lines, including one with deletions of two X-chromosomal counterselectable (negative selection) markers, PIGA and HPRT1, and additional cell lines bearing each individual deletion. PIGA encodes a component of the glycosylphosphatidylinositol (GPI) anchor biosynthetic apparatus. The PIGA gene counterselectable marker has unique features, including existing single cell level assays for both function and loss of function of PIGA and the existence of a potent counterselectable agent, proaerolysin, which we use routinely for selection against cells expressing PIGA. These designer cell lines may serve as a general platform with multiple selection markers and may be particularly useful for large scale genome engineering projects such as Genome Project-Write (GP-write).