bluuebunny/crossref_metadata_2025_split huggingface dataset:
Análisis comparativo de juntas soldadas mediante el proceso GMAW con técnicas de inspección visual e inspección visual mediante visión artificial
Authors: Escorcia-Barrios Federico , Medina-Cárdenas Armando , Cuello-Navarro José , Velázquez Gutiérrez Kevin , Escorcia-Gutiérrez José , Soto-Díaz Roosvel 
Published: December 2021

En este trabajo se realizó un análisis comparativo entre inspección visual (IV) y la inspección visual mediante visión artificial (IVA), para la evaluación de la calidad superficial de uniones soldadas de acero inoxidable austenítico AISI 304, mediante el proceso GMAW. Para determinar los criterios de evaluación se tuvieron en cuenta los códigos AWS D1.6 y guías de inspección AWS parte B, conociéndose así los tipos de discontinuidades y defectos que se pueden presentar en una unión de soldadura, los criterios de aceptación y aplicación de las técnicas de inspección. Posteriormente se diseñaron y generaron muestras soldadas a las cuales se les indujeron discontinuidades y defectos, identificándose como principales el exceso de penetración, falta de penetración, falta de continuidad, porosidad y salpicaduras. Teniendo las placas soldadas se realizó, de manera inicial, la evaluación de estas aplicando técnicas y normas de inspección visual.
En segundo lugar, se implementó el método de evaluación mediante inspección visual y mediante visión artificial (IVA) para las probetas evaluadas anteriormente, a través de inspección visual (IV). Como resultado se realizó el respectivo análisis comparativo de los resultados obtenidos con ambas técnicas y se determinó que las probetas evaluadas por ambos métodos de inspección presentaron resultados similares y confiables, la inspección visual sigue siendo el método tradicional para evaluar la soldadura, sin embargo, la inspección visual mediante visión artificial demostró ser un método novedoso en el que se pudo resaltar de manera más eficiente la identificación de los poros, salpicadura, falta de continuidad y falta de penetración.
Identification of high protein kinase CK2α in HPV(+) oropharyngeal squamous cell carcinoma and correlation with clinical outcomes
Authors: Trembley Janeen H. , Li Bin , Kren Betsy T. , Peltola Justin , Manivel Juan , Meyyappan Devi , Gravely Amy , Klein Mark , Ahmed Khalil , Caicedo-Granados Emiro 
Published: December 2021

Background
Oropharyngeal squamous cell carcinoma (OPSCC) incidence is rising worldwide, especially human papillomavirus (HPV)-associated disease. Historically, high levels of protein kinase CK2 were linked with poor outcomes in head and neck squamous cell carcinoma (HNSCC), without consideration of HPV status. This retrospective study examined tumor CK2α protein expression levels and related clinical outcomes in a cohort of Veteran OPSCC patient tumors which were determined to be predominantly HPV(+).

Methods
Patients at the Minneapolis VA Health Care System with newly diagnosed primary OPSCC from January 2005 to December 2015 were identified. A total of 119 OPSCC patient tumors were stained for CK2α, p16 and Ki-67 proteins and E6/E7 RNA. CK2α protein levels in tumors and correlations with HPV status and Ki-67 index were assessed. Overall survival (OS) analysis was performed stratified by CK2α protein score and separately by HPV status, followed by Cox regression controlling for smoking status. To strengthen the limited HPV(−) data, survival analysis for HPV(−) HNSCC patients in the publicly available The Cancer Genome Atlas (TCGA) PanCancer RNA-seq dataset was determined for CSNK2A1.

Results
The patients in the study population were all male and had a predominant history of tobacco and alcohol use. This cohort comprised 84 HPV(+) and 35 HPV(−) tumors. CK2α levels were higher in HPV(+) tumors compared to HPV(−) tumors. Higher CK2α scores positively correlated with higher Ki-67 index. OS improved with increasing CK2α score and separately OS was significantly better for those with HPV(+) as opposed to HPV(−) OPSCC. Both remained significant after controlling for smoking status. High CSNK2A1 mRNA levels from TCGA data associated with worse patient survival in HPV(−) HNSCC.

Conclusions
High CK2α protein levels are detected in HPV(+) OPSCC tumors and demonstrate an unexpected association with improved survival in a strongly HPV(+) OPSCC cohort. Worse survival outcomes for high CSNK2A1 mRNA levels in HPV(−) HNSCC are consistent with historical data. Given these surprising findings and the rising incidence of HPV(+) OPSCC, further study is needed to understand the biological roles of CK2 in HPV(+) and HPV(−) HNSCC and the potential utility for therapeutic targeting of CK2 in these two disease states.
Profile Analysis of Tribal Farmers of Vidarbha Region
Authors: Gandhale A. A. , Tekale V. S. 
Published: December 2021

In Maharashtra 10.33 million population belonged to tribal’s. Tribal people constitute the most deprived and neglected section of the population of the state, hence the research objective was formulated to study the profile of tribal farmers of Vidarbha region. An exploratory research design of social science was used for the present investigation. Study was conducted in Gadchiroli and Yavatmal districts in the year 2020, with 280 respondents. The findings suggested that, relatively high per cent (44.28%) of the respondents were belonged to middle age (36 to 50 years) group category, more than one fourth (29.30%) of the respondents were educated up to primary school level, nearly half (48.92%) of the respondents concentrated in medium size of family with 5 to 6 members in the family, majority (54.64%) of the respondent tribal farmers were belonged to nuclear type of family, relatively high per cent of the respondents (46.43%) involved in agriculture, majority of the respondent tribal farmers (72.14%) had annual earning up to Rs. 80,000/-, more than half (51.78%) of the respondents had small size of land holding (1.01 to 2.00 ha.), majority (52.85%) of the respondents had medium (24 to 43 years) farming experience, majority (71.43%) of the respondents had medium level of social participation, majority (73.92%) of the respondents were using medium level of sources of information, majority (54.64%) of the respondent tribal farmers belonged to medium innovativeness category, majority (63.92%) of the respondents had medium cosmopolitness in nature, majority (75.71%) of the respondent tribal farmers had medium level of change orientation, whereas 56.07 per cent had medium level of fatalism, more than three fourth of the respondents (78.21%) had derived medium level of benefits.
Analysis of Students' Mathematical Reasoning Ability with the Constructivism Approach through Mobile Learning System
Authors: Wahyuni Yusri , Jamaris . 
Published: December 2021

Aims: To analyze the mathematical reasoning ability of mathematics education students.
Study Design: Qualitative research with a descriptive approach.
Place and Duration of Study: The population of all 3rd-semester mathematics education students at Bung Hatta University who take geometry courses is 25 students.
Methodology: This research is qualitative research with a descriptive approach. Researchers directly measure the mathematical reasoning ability of students in the mathematics education study program. Judging from the research subjects, the population of all 3rd-semester mathematics education students at Bung Hatta University who took geometry courses was 25 students.
Results: From the analysis results, it was found that the achievement of mathematical reasoning abilities for indicators of students' ability to present mathematical statements orally, in writing, pictures, and diagrams indicated by question number 1 was 74% (Good Category). The indicators of mathematical manipulation ability shown in questions number 2 and 5 are 41% (Category Enough), and 42% (Category Enough). And the indicators of students' ability to conclude, compile evidence, provide comments, or evidence from several solutions shown by questions number 3 and 4 are 67% (Good Category) and 58% (Enough Category).
Conclusion: The conclusion of this study is to be able to determine the category of mathematical reasoning of the 3rd-semester students of the Bung Hatta University Mathematics Education Study Program.
Aqueous Extract of Alstonia boonei Bark Reduces Chronic Hyperglycemia and Prevents its Complications through Increase of Hepatic Global Dna Methylation in Diabetic Wistar Rats
Authors: Fonkoua Martin , Arnold W. Tazon , Ntentié R. Françoise , Kingue B. Azantsa , Nguemto G. Takuissu , Judith L. Ngondi , Enyong J. Oben 
Published: December 2021

Aim: DNA methylation profile is involved in several physiological processes. Its alterations in the liver of diabetic patients characterized by global hypomethylation are associated with the pathophysiology of type 2 diabetes and its complications. The present study has evaluated the effect of the aqueous extract of Alstonia boonei barks on the global methylation of hepatic DNA in association with hyperglycemia and diabetes complications induced by high-fat diet (HFD) feeding and administering of streptozotocin (STZ) which mimics the metabolic abnormalities very similar to those seen in human Type 2 diabetes.
Methods: A. boonei barks were harvested, processed, dried, ground and an aqueous extraction was prepared (ratio 1/10 w/v). An in vivo study was conducted in an animal model of high-fat-streptozotocin (HF-STZ) induced diabetes. Rats were divided into five groups of five rats each: a normoglycemic group, an untreated hyperglycemic group, three hyperglycemic groups including two test groups receiving aqueous extract of A. boonei barks (AEAB) by esophageal gavage at the doses of 200 and 400 mg/kg body weight once daily and a reference group receiving metformin at 10 mg/kg body weight. After 28 days of experimentation during which fasting blood glucose levels were taken every 14 days under fasting conditions, the animals were sacrificed. Plasma and liver homogenate samples from the sacrificed rats were used for biochemical assays (markers of oxidative stress such as malondialdehyde level, superoxide dismutase (SOD) and catalase activity, and markers of lipid profile such as total cholesterol, and triglycerides, HDL-c, LDL-c and VLDL-c). The analysis of the global DNA methylation profile was performed by the immunoprecipitation. Pearson's correlation was used to evaluate the relationship between the values.
Results: The aqueous extract increased the hepatic DNA methylation by 0.41% and 0.63% at 200 and 400 mg/kg body weight, respectively, compared to metformin (0.47%±0, 05). This effect was significantly associated with the hypoglycemic effect obtained at 400 mg/kg body weight with a decrease in initial blood glucose level of -29.87%.
Conclusion: AEAB reduces chronic hyperglycemia and prevents its complications by increasing global hepatic DNA methylation.
Influence of Nutrient Concentration on Growth, Yield And Quality of Spinach (Spinacia oleracea L.) in Hydroponic System
Authors: Sutnga Baiamonlangki , Bahadur Vijay , Kerketta Anita 
Published: December 2021

The present experiment entitled “Influence of nutrient concentration on Growth, Yield and Quality of Spinach (Spinacia oleracea L.) in Hydroponic system” was carried out in Shade net, Research Field, Department of Horticulture, SHUATS, Prayagraj during March- April,2020.. The experiment was laid out in complete randomized design (CRD), with eight treatments, replicated thrice with nutrient field technique hydroponics system and variety Mulayam of Spinach, the treatments were T1 (NPK 6.25 ml/plant), T2 (NPK 8.33 ml/plant), T3 (NPK 10.41 ml/plant), T4 (NPK 12.5 ml/plant), T5 (NPK 14.58 ml/plant), T6 (NPK 16.66 ml/plant), T7 (NPK 18.75 ml/plant) and T0 (NPK 0 ml/plant). From the present experimental findings, it is found that structure with treatment T4 was found best in terms of Growth and yield parameters of spinach in NFT hydroponic system followed by structure with T3 and T1 due to appropriate supply of plant nutrients and the water treated plants had the lowest values. Maximum gross return (1871.30Rs) and net return (746.30 Rs) and maximum benefit cost ratio (1.66) was also observed in treatment T4. As seen from the experiment, it was observed that the treatment T4 was ideal nutrient for Spinach good growth and yield. Therefore, an ideal nutrient concentration helps the plants in good growth and yield.
Synergistic Effect of Docetaxel Plus Saponin Fraction of Vitex doniana on Prostate Specific Antigen and p53 in Nitrsobis (2-oxopropyl) Amine-induced Prostate Toxicity
Authors: Abireh Ifeanacho Ezeteonu , Anyanwu Godson Emeka 
Published: December 2021

Aim: This study investigated the synergistic effect of docetaxel plus saponin fraction of Vitex doniana on prostate specific antigen and p53 in nitrsobis (2-oxopropyl) amine-induced prostate toxicity in Wistar rat.
Methodology: Twenty-four (24) male Wistar rats with elevated serum prostate specific antigen level were selected from a group of sixty (60) rats pretreated with subcutaneous Nitrosobis (2-oxopropyl) amine 5 mg/kg daily for 4 weeks. The selected 24 male Wistar rats were then grouped into 6 groups of four (4) rats each. Group 1 was given 1ml normal saline daily from day 1-28. Groups 2, 3, 4, 5, and 6 further received subcutaneous nitrosobis (2-oxopropyl) amine 5 mg/kg daily from day 1-28. In addition, groups 3, 4, 5, and 6 were given weekly intravenous docetaxel 8 mg/kg on day 15 and 22. In addition to docetaxel, groups 4, 5, and 6 were further treated with oral saponin at 250 mg/kg, 500 mg/kg, and 750 mg/kg, respectively, daily, from day 15-28. Immunoenzymometric assay method was used for analysis of blood sample for prostate specific antigen. The prostate tissues were subjected to immuno study using the ImmunoCruz Staining System (Lab Vision Corporation, Fremont, CA, USA). The quantitative evaluation of p53 was done by calculating the percentages of p53-immunostained nuclei (labeling index).
Results: Significant increase in prostate specific antigen and p53 expression were observed in group 2 (treated with Nitrsobis (2-oxopropyl) amine alone) when compared with group 1 (control). Dose dependent decrease in prostate specific antigen and p53 expression were observed in groups 4, 5, and 6, treated with docetaxel 8 mg/kg plus 250 mg/kg, 500 mg/kg, and 750 mg/kg of saponin respectively.
Conclusion: Docetaxel plus Saponin fraction of Vitex doniana significantly reduced the serum prostate specific antigen concentration and p53 expression in a dose dependent manner, with the group treated with 750 mg/kg showing the highest decrease in the parameters tested.
Impact of Placenta Previa on Fetal Growth
Authors: Elrewany Hassan Abubakr , El Namori Mohamed Mohsen , Elshourbagy Shahinaz Hamdy , Awarah Ahmed Mahmoud 
Published: December 2021

Background: Placenta Previa refers to the presence of placental tissue that extends over the internal cervical is during pregnancy. The incidence of this condition is reported to be 2% at 20 weeks of gestation and decreases to around 4–6 per 1000 births between 34 and 39 weeks through trophotropism. The aim of the work is to evaluate fetal growth in pregnancies complicated by placenta Previa.
Methods: This cross-sectional study was done on 100 pregnant females with placenta Previa aged 18-35 years. Cases were defined as patients with gestational age 24-40 weeks, BMI 18-30 kg/m2, Singleton fetus and diagnosed having placenta Previa; confirmed by trans-vaginal ultrasound in the second and third trimester. Complete history, vital signs and complete obstetric examination, laboratory and radiological investigations (ultrasound done trans-abdominally to evaluate fetal weight, biometry and Doppler studies) were taken.
Results: The gestational age ranged from 34-39 weeks with a mean value 36.03 ± 1.23 weeks and a median value 36 weeks (IQR = 35-37 weeks). The femur length ranged from 33.14-39.14 weeks with a mean value 35.44 ± 1.56 weeks and a median value 35.14 weeks (IQR = 34-36.9 weeks).The abdominal circumference ranged from 32.86-39.14 weeks with a mean value 35.43 ± 1.65 weeks with a median value 35.14 weeks (IQR = 33.9-36.7 weeks).
As regard to umbilical (UA) and middle cerebral (MCA) arteries Doppler resistant index (RI), UA ranged from 0.48-0.58 with a mean value 0.53 ± 0.03 and a median value 0.53 (IQR = 0.51-0.55). MCA ranged from 0.75-0.85 with a mean value 0.80 ± 0.03 and a median value 0.79 (IQR = 0.77-0.82).
Conclusion: Placenta Previa led to preterm delivery (<36 weeks) in about one third of the study cases. Femur length was <36 weeks in 65 patients. Abdominal circumference was <36 weeks in 61 patients. Placenta Previa had insignificant effect on umbilical (UA) and middle cerebral arteries Doppler resistant index.
A Prospective Observational Study on Diabetic Induced Complications and their Prone towards Surgery
Authors: Chetty C. Madhusudhana , Mabichan K. , Sandhya H. Raga , Mallikarjuna K. 
Published: December 2021

Background: This study was mainly aimed to find out the diabetic complications that had been lead to surgey. The Diabetes mellitus describes a metabolic disorder of multiple aetiology characterized by chronic hyperglycaemia with disturbances of carbohydrate,fat and protein metabolism resulting from defects in insulin secretion,insulin action, or both.The effects of diabetes mellitus include long-term damage,dysfunction and failure of various organs.
Materials and Methods: A prospective observational study was conducted in the Santhiram college & general hospital for 6 months (December 2020 – May 2021)to assess the macro vascular and micro vascular complications of diabetes mellitus and prone to surgery of diabetic complications by using case sheets, prescriptions in tertiary care teaching hospital.
Results: A total of 150 patients are included in this study.In patients with diabetic complications we have observed: Diabetic ulcer with cellulitis in 19, gangrene in 19, peripheral vascular disease in 6, gangrene with cellulitis in 11,Non healing diabetes foot ulcer in 35, Coronary artery disease 24, diabetic retinopathy 25, MI in 11 patients.Among all complications, non healing diabetic foot was observed to be more when compared to other diabetic complications.In the study performed in diabetic induced complications of patients, debridement was performed in 30% patients, Amputation were performed in 13%, skin grating was performed in 13% patients, Angioplasty were performed in 23% patients and lasix surgery performed in 13% patients.
Conclusion: In our study we conclude that out of 150 cases, male patients are more prone to diabetic complications than females.The patient counselling should involve in minimizing the incidence and prevalence of diabetes by conducting the continuing health education and other health programms.
Effective Treatment of a Post-renal Transplantation Patient with Early Recurrent Focal Segmental Glomerulosclerosis and Concomitant Hemolytic Uremic Syndrome, a Case Report
Authors: Alsawadi Abdullah , Aloufi Majed , Fatta Ahmed , Almowaina Sahar , Elami Mugahid , Albahili Hamad , Zahid Rafat , Alyami Ali 
Published: December 2021

While recurrence of primary Focal Segmental Glomerular Sclerosis (FSGS) is common post renal transplantation (30%-80%), a concomitant presentation of hemolytic uremic syndrome (HUS) and recurrent FSGS has never been reported. In addition, treatment of recurrent FSGS and HUS post-renal transplantation is challenging; and usually individualized based on center's experience. Here, we reported a case of a pediatric patient with early recurrence of FSGS and concomitant HUS post-renal transplantation. This patient had a complete hematological and renal response following the administration of Eculizumab and Rituximab, respectively. Withdrawal of Tacrolimus as well as plasmapheresis did not improve kidney function. Therefore, we concluded that both Eculizumab and Rituximab could achieve remission in comparable cases when administered at fixed intervals.
Phytochemicals against COVID -19, Pharmacological Perspectives: A Systematic Review
Authors: Ali Ahmed S. , Saied Ekram A. , Theeban Sharifa M. , Humayran Mazen M. , Shaker Assmaa Ahmed , Alfadil Abdelbagi , Almuhayawi Mohammed S. 
Published: December 2021

Background: Many publications discussed the potential role of medicinal plants in the management of COVID-19. However, clinical studies of the efficacy and safety of specified phytochemical(s) are limited.
Objectives: To explore the pharmacological profile of specified compounds against COVID-19
Method: Systematic literature search of academic databases to explore specified phytochemicals for the management of COVID-19 using appropriate search terms. Rayyan software was used to organize 786 citations of which. 236 articles were included in this review.
Results: Initially 70 compounds were identified to have a potential role in the management of COVID-19. In this review, 18 compounds were selected for further search
Conclusion: In vitro anti-SARS-CoV-2activity has been demonstrated for a variety of natural compounds. However, preclinical research for most phytochemicals is scarce, and only a few compounds have been evaluated in clinical trials against COVID-19. A comprehensive pharmacological profile of these phytochemicals is urgently needed.
Effect of Ayurvedic Interventions on Toxemia of Pregnancy (Preeclampsia) & Fetal Outcome- A Randomized Placebo-Controlled Trial
Authors: Rathi Renu , Sharma Geeta , Sastry C. H. S , Kumar Abhimanyu , Verma Jitesh , Rathi Bharat , Khedekar Sumod 
Published: December 2021

Background: Toxemia of pregnancy also known as preeclampsia is a common clinical condition affecting 8-10% pregnancies worldwide. It has adverse outcome both for mother and fetus. The management options are mainly targeted to prevent adverse outcomes associated to premature births, such as administration of antenatal corticosteroids and magnesium sulphate infusions.
Aim & Objectives: The main aim of the study was to evaluate efficacy of Ayurvedic interventions in management of toxemia and in prevention of premature delivery as well as fetal hazards due to pre-eclampsia.
Methods: It was an open ended, parallel group, randomized placebo controlled clinical trial with equal allocation in both the groups. Sample size was 15 in each group. Trial group was administered Gokshura Siddha Yavagu(Green gram gruel medicated with Tribulus terrestris Linn) and Dhatryavaleha (linctus prepared with Ayurveda medicines like Phyllanthus emblica L.)while control group was treated with similar looking placebo-linctus.
Results: Both ayurvedic parameters-Shotha(edema), Avil mutrata (Discolored urine) & clinical features of toxemia have shown excellent relief while control group patients either show poor or no relief when assessed by USG scan and needed further treatment with induction of labor.
Conclusion: This study concludes that Ayurvedic interventions in the form of Gokshura siddha Yavagu and Dhatri Avleha can provide significant symptomatic relief (p<0.0001) in toxemia of pregnancy and can also promote normal growth and development in fetus.