bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbon intensity of corn ethanol in the United States: state of the science
Authors: Scully Melissa J , Norris Gregory A , Alarcon Falconi Tania M , MacIntosh David L 
Published: January 2021

Abstract
The carbon intensity (CI) of corn ethanol, the primary renewable fuel used in transportation, has been actively researched and quantified over the last three decades. Reliable estimates of greenhouse gas (GHG) emissions for corn ethanol are important since these values help determine significant policy and market decisions on state, national, and international levels. We reviewed well-to-wheel GHG life cycle analyses (LCAs) for corn ethanol and evaluated models, input data, and results for farming, fuel production, co-product credit, land use change (LUC), transport of feedstock and fuel, tailpipe, and denaturant. Compared to earlier analyses, recent LCAs for corn ethanol contain updates to modeling systems and data that reflect: (a) market-driven changes in corn production that lowered the intensity of fertilizer and fossil fuel use on farms; (b) more efficient use of natural gas and recent electric generation mix data for energy consumed at ethanol refineries, and (c) LUC analyses based on hybrid economic-biophysical models that account for land conversion, land productivity, and land intensification. LCAs that include these latest developments yield a central best estimate of CI for corn ethanol of 51.4 gCO2e MJ−1 (range of 37.6–65.1 gCO2e MJ−1) which is 46% lower than the average CI for neat gasoline. The largest components of total CI are ethanol production (29.6 gCO2e MJ−1, 58% of total) and farming practices net of co-product credit (13.2 gCO2e MJ−1, 26%), while LUC is a minor contributor (3.9 gCO2e MJ−1, 7%). Market conditions that favor greater adoption of precision agriculture systems, retention of soil organic carbon, and demand for co-products from ethanol production may lower the CI of corn ethanol further. Continued refinement of models to account for co-products, conservation of soil carbon, and direct and indirect LUC is expected to produce ever more accurate estimates in the future.
Hydrogen production by the photoreforming of methanol and the photocatalytic water–gas shift reaction
Authors: Kennedy Julia , Hayward James , Davies Philip R , Bowker Michael 
Published: January 2021

Abstract
We have examined the reforming of methanol and CO on Pd/P25 TiO2 catalysts for hydrogen production, and compared it with rates for similarly supported Au and Cu catalysts. Both reactions proceed, but the photocatalytic water–gas shift (WGS) reaction is much slower than for methanol reforming. CO2 is evolved as expected, but the yields can be much lower than for the expected stoichiometry (CH3OH + H2O → CO2 + 3H2). We show that this is due to dissolution of the carbon dioxide into the aqueous phase. We have also carried out both reactions in the gas phase. Both proceed at a higher rate in the gas phase, and for methanol reforming, there is some CO evolution. In H2 + CO2 reactions, there is little sign of the reverse WGS reaction, but some photo-methanation does occur. Of the three catalysts Pd is the best for the methanol reforming reaction, while Au is best for the water–gas shift. Nonetheless, Cu works reasonably well for methanol reforming and makes a much cheaper, earth-abundant catalyst.
Enhanced electrochemical performance of hierarchical porous carbon/polyaniline composite for supercapacitor applications
Authors: Rawal Sangeeta , Mandal U K , Kumar Ashwani , Kumar Yogesh , Joshi Bhawana 
Published: January 2021

Abstract
In this work, activated carbon/polyaniline (AC/PANi) composites were synthesized by low temperature in situ polymerization and their electrochemical performance was investigated. Microstructure and morphology examination of the samples confirmed a uniform coating of polyaniline on AC surfaces without any change in the structure. The electrochemical studies of the samples confirmed the improvement in the electrochemical performance of AC/PANi composites. Despite a decrease in the specific surface area a substantial increase in electrochemical performance is recorded for the AC/PANi composites due to the synergistic effect between the pseudocapacitance and double layer capacitance. The highest specific capacitance of 1021 F g−1 was calculated for the APA-29.4 composite in neutral aqueous electrolyte (1 M Na2SO4) which is many times greater than the specific capacitance values for AC (253 F g−1) and PANi (389 F g−1). The enhancement in the electrochemical performance of AC after polymerization with PANi in composites favours its use as a favourable electrode material for the energy storage devices.
Trouton-Noble-like experiments on suspended capacitors
Authors: Porcelli Elio B , Filho Victo S 
Published: January 2021

Abstract
We performed several measurements of angular velocities on a suspended monolayer capacitor subjected to high electric voltages. The experimental setup is similar to that reported by Trouton and Noble, but which presented negative results for the rotation of the device. The measurements were made without or with electromagnetic shielding in the capacitor. We measured a small torque on the device which caused its rotation in both configurations. The runs performed with and without electromagnetic shielding covering the capacitor, more or less insulation covering the elements of setup, several changes in the space separation between those elements and the small magnitude of the monitored current in the capacitor indicates that ion wind, electrostatic interaction and also the interaction with the Earth's magnetic field via leakage current cannot explain the magnitude of angular velocity or rotation effect. We hope that the data of our experiments can contribute for enhancement of understanding of the old puzzle.
Implementation of a formal pharmacy residency research certificate program
Authors: Darko William , Seabury Robert W , Miller Christopher D , Spinler Sarah A , Probst Luke A , Cleary Lynn M , Kelly Courtney , Kufel Wesley D 
Published: January 2021

Abstract

Purpose
We describe the structure, implementation, and initial evaluation of a formal residency research certificate program (RRCP) designed to further advance residents’ knowledge and skills in research in an effort to better prepare residents for research involvement during their careers.

Summary
Pharmacy residency programs vary in the degree of emphasis on research education and training and the structure of resident research activities. Limited data describing formal research education and training for pharmacy residents are available. To better educate and prepare residents in the research process, State University of New York Upstate University Hospital developed and implemented a formal RRCP designed to educate and train residents in essential areas of the research process. Research seminars are delivered by preceptors with experience and training in research throughout the academic year to align with residency project tasks. Residents are also required to complete at least 1 residency project and submit a manuscript suitable for publication in a peer-reviewed journal. Upon successful completion of the program and project requirements, residents earn a certificate of completion. Initial data collected through formal resident assessments before and after RRCP completion demonstrated significant improvement in research knowledge (from an average score of 61.3% out of 100% to an average score of 84.7%, P = 0.002).

Conclusion
Post-RRCP assessment showed improvements in residents’ confidence in several areas of research, including but not limited to research project design, ethical and regulatory principles of research, data collection, selection of appropriate statistical tests, manuscript writing, and the publication process. Residents strongly agreed that the RRCP improved their overall knowledge and perceptions of research.
Standards for Surgical Respirators and Masks: Relevance for Protecting Healthcare Workers and the Public During Pandemics
Authors: Jones Rachael M , Rempel David 
Published: January 2021

Abstract
National standards for surgical respirators and masks are written and enforced to protect healthcare workers from particles and microorganisms such as Severe Acute Respriatory Syndrome Coronavirus 2 (SARS-CoV-2). In addition to the ability to filter particles (e.g. filtration efficiency, FE), the standards address breathability (e.g. differential pressure), how well the mask seals to a worker’s face (e.g. fit test), the level of protection from a fluid splash, and other factors. Standards used in the USA, European Union (EU), and China were compared with respect to testing methods and certification criteria. Although there are substantial similarities in standards for respirators, such as surgical N95, FFP2, and KN95 filtering facepiece respirators (FFRs), there are differences with respect to who performs that testing and fit-testing requirements that influence certification. There is greater variation in test methods between countries for surgical (USA) or medical (EU and China) masks than for FFRs. Surgical/medical masks can be certified to different levels of protection. The impact of the similarities and differences in testing methods and certification criteria on FFR and mask performance for protecting healthcare workers from SARS-CoV-2 are discussed, as well as the value of a new standard in the EU for testing fabrics for masks used by the public. Health and safety personnel in healthcare settings must understand the differences between standards so that they can select respirators and masks that provide appropriate protection for healthcare workers.
The leaf economics spectrum’s morning coffee: plant size-dependent changes in leaf traits and reproductive onset in a perennial tree crop
Authors: Martin Adam R , Isaac Marney E 
Published: January 2021

Abstract

Background and Aims
Size-dependent changes in plant traits are an important source of intraspecific trait variation. However, there are few studies that have tested if leaf trait co-variation and/or trade-offs follow a within-genotype leaf economics spectrum (LES) related to plant size and reproductive onset. To our knowledge, there are no studies on any plant species that have tested whether or not the shape of a within-genotype LES that describes how traits covary across whole plant sizes, is the same as the shape of a within-genotype LES that represents environmentally driven trait plasticity.

Methods
We quantified size-dependent variation in eight leaf traits in a single coffee genotype (Coffea arabica var. Caturra) in managed agroecosystems with different environmental conditions (light and fertilization treatments), and evaluated these patterns with respect to reproductive onset. We also evaluated if trait covariation along a within-genotype plant-size LES differed from a within-genotype environmental LES defined with trait data from coffee growing in different environmental conditions.

Key Results
Leaf economics traits related to resource acquisition – maximum photosynthetic rates (A) and mass-based leaf nitrogen (N) concentrations – declined linearly with plant size. Structural traits – leaf mass, leaf thickness, and leaf mass per unit area (LMA) – and leaf area increased with plant size beyond reproductive onset, then declined in larger plants. Three primary LES traits (mass-based A, leaf N and LMA) covaried across a within-genotype plant-size LES, with plants moving towards the ‘resource-conserving’ end of the LES as they grow larger; in coffee these patterns were nearly identical to a within-genotype environmental LES.

Conclusions
Our results demonstrate that a plant-size LES exists within a single genotype. Our findings indicate that in managed agroecosystems where resource availability is high the role of reproductive onset in driving within-genotype trait variability, and the strength of covariation and trade-offs among LES traits, are less pronounced compared with plants in natural systems. The consistency in trait covariation in coffee along both plant-size and environmental LES axes indicates strong constraints on leaf form and function that exist within plant genotypes.
Discrimination of a single nucleotide polymorphism in the haptoglobin promoter region, rs5472, using a competitive fluorophore-labeled probe hybridization assay following loop-mediated isothermal amplification
Authors: Michiyuki Satoru , Tomita Norihiro , Mori Yasuyoshi , Kanda Hidetoshi , Tashiro Kosuke , Notomi Tsugunori 
Published: January 2021

ABSTRACT
Personalized peptide vaccination, which involves activation of the host immune system against cancer cells using personalized peptide vaccines (PPVs), can improve overall survival in multiple cancer types. However, the clinical efficacies of PPVs vary for unknown reasons. Recently, a single nucleotide polymorphism (NG_012651.1:g.4461_5460[4960A&gt;G]) in the haptoglobin promoter region, rs5472, was significantly associated with clinical response of PPV. Therefore, rs5472 is expected to be a predictive biomarker for PPV therapy. Here, we described a single nucleotide discrimination method for rs5472 analysis by combining the loop-mediated isothermal amplification and quenching probe methods. In evaluation of saliva samples, this method showed high concordance with the results of Sanger sequencing (100%, n = 36). Importantly, this method did not require calculation of melting temperature for single nucleotide discrimination and could therefore be carried out on a simple instrument. Accordingly, this method may be more robust and applicable to near-patient testing.
Role of gambogenic acid in regulating PI3K/Akt/NF-kβ signaling pathways in rat model of acute hepatotoxicity
Authors: Ding Zhongyang , Li Ying , Tang Zhangfeng , Song Xiaoyi , Jing Fa , Wu Haotian , Lu Bei 
Published: January 2021

ABSTRACTThe purpose of this study is to investigate the protective effect of gambogenic acid (GA) in acetaminophen (APAP)-induced hepatotoxicity in rat models. GA (10 mg/kg) was administered intraperitoneal (i.p.) to rats for 7 consecutive days followed by APAP (500 mg/kg) single dose (i.p.) on the final day after GA administration. The levels of MDA, GSH, SOD, CAT, GPx, GST, ALP, AST, ALT, proinflammatory cytokines (TNF-α, IL-1β, IL-6), apoptosis markers (caspase-3 and -9, Bax, Bcl-2), 4-hydroxynonenal (4-HNE), and prostaglandin E2 (PGE2) were evaluated. Results exhibited protective effects of GA by inhibiting inflammation, preventing oxidative stress and apoptosis in APAP-induced liver. Histopathological changes caused by APAP were attenuated, protein expressions of phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) were upregulated, and nuclear factor–kappa β (NF-kβ) was downregulated by GA. In summary, GA significantly exerted anti-inflammatory and antiapoptotic effects against APAP-induced hepatotoxicity potentially through regulation of PI3K/Akt and NF-kβ signaling pathways.
Vitamin C affects G0/G1 cell cycle and autophagy by downregulating of cyclin D1 in gastric carcinoma cells
Authors: Ren Chenxia , Wu Cuiling , Yang Changqing , Lian Changhong 
Published: January 2021

ABSTRACT
Vitamin C has re-emerged as a promising anticancer agent. This study attempts to analyze the differential gene expression of profiles GSE11919 to look for some clues, and the most significant cell cycle pathway caused by vitamin C was identified by integrated bioinformatics analysis. Inspired by this, we investigated the effect of vitamin C treatment on gastric carcinoma cells by detection of cell cycle, apoptosis, and autophagy. Vitamin C significantly elevated the percentage of cells at G0/G1 phase, whereas the percentage of S phase cells was decreased. Meanwhile, vitamin C treatment resulted in downregulation of cell cycle-related protein Cyclin D1. We deduced that the downregulation of Cyclin D1 by vitamin C accompanied by significantly increased 5′AMP-activated protein kinase and induced autophagy in MKN45 cells. These results suggest that vitamin C has the antiproliferation effect on gastric carcinoma cells via the regulation of cell cycle and autophagy by Cyclin D1.
Single-use negative-pressure wound therapy versus conventional dressings for closed surgical incisions: systematic literature review and meta-analysis
Authors: Saunders C , Nherera L M , Horner A , Trueman P 
Published: January 2021

Abstract

Background
Surgical-site complications (SSCs) remain a significant cause of morbidity and mortality, particularly in high-risk patients. The aim of this study was to determine whether prophylactic use of a specific single-use negative-pressure wound therapy (sNPWT) device reduced the incidence of SSCs after closed surgical incisions compared with conventional dressings.

Methods
A systematic literature review was performed using MEDLINE, Embase and the Cochrane Library to identify articles published from January 2011 to August 2018. RCTs and observational studies comparing PICO™ sNPWT with conventional dressings, with at least 10 patients in each treatment arm, were included. Meta-analyses were performed to determine odds ratios (ORs) or mean differences (MDs), as appropriate. PRISMA guidelines were followed. The primary outcome was surgical-site infection (SSI). Secondary outcomes were other SSCs and hospital efficiencies. Risk of bias was assessed.

Results
Of 6197 citations screened, 29 studies enrolling 5614 patients were included in the review; all studies included patients with risk factors for SSCs. sNPWT reduced the number of SSIs (OR 0.37, 95 per cent c.i. 0.28 to 0.50; number needed to treat (NNT) 20). sNPWT reduced the odds of wound dehiscence (OR 0.70, 0.53 to 0.92; NNT 26), seroma (OR 0.23, 0.11 to 0.45; NNT 13) and necrosis (OR 0.11, 0.03 to 0.39; NNT 12). Mean length of hospital stay was shorter in patients who underwent sNPWT (MD −1.75, 95 per cent c.i. −2.69 to −0.81).

Conclusion
Use of the sNPWT device in patients with risk factors reduced the incidence of SSCs and the mean length of hospital stay.
Electronic collection of patient-reported outcomes following discharge after surgery: systematic review
Authors: Tsang C , Lee K S , Richards H , Blazeby J M , Avery K N L 
Published: January 2021

Abstract

Background
Little is known about the electronic collection and clinical feedback of patient-reported outcomes (ePROs) following surgical discharge. This systematic review summarized the evidence on the collection and uses of electronic systems to collect PROs after discharge from hospital after surgery.

Method
Systematic searches of MEDLINE, Embase, PsycINFO, CINAHL and Cochrane Central were undertaken from database inception to July 2019 using terms for ‘patient reported outcomes’, ‘electronic’, ‘surgery’ and ‘at home’. Primary research of all study designs was included if they used electronic systems to collect PRO data in adults after hospital discharge following surgery. Data were collected on the settings, patient groups and specialties, ePRO systems (including features and functions), PRO data collected, and integration with health records.

Results
Fourteen studies were included from 9474 records, including two RCTs and six orthopaedic surgery studies. Most studies (9 of 14) used commercial ePRO systems. Six reported types of electronic device were used: tablets or other portable devices (3 studies), smartphones (2), combination of smartphones, tablets, portable devices and computers (1). Systems had limited features and functions such as real-time clinical feedback (6 studies) and messaging service for patients with care teams (3). No study described ePRO system integration with electronic health records to support clinical feedback.

Conclusion
There is limited reporting of ePRO systems in the surgical literature, and ePRO systems lack integration with hospital clinical systems. Future research should describe the ePRO system and ePRO questionnaires used, and challenges encountered during the study, to support efficient upscaling of ePRO systems using tried and tested approaches.
Safety and feasibility of laparoscopic surgery for elderly rectal cancer patients in Japan: a nationwide study
Authors: Seishima R , Miyata H , Okabayashi K , Hasegawa H , Tsuruta M , Shigeta K , Monno M , Yamashita Y , Inomata M , Wakabayashi G , Kakeji Y , Kitagawa Y , Watanabe M 
Published: January 2021

Abstract

Background
This study aimed to analyse the perioperative results from a national dataset of rectal cancer resections in elderly patients.

Methods
The clinical records of patients undergoing rectal cancer surgery between 2012 and 2014 were retrieved from the Japanese National Clinical Database and analysed retrospectively. Patients were categorized according to age and those 80 years or older were defined as elderly. Subgroups were also defined according to the surgical approach (laparoscopy versus open surgery). The short-term outcomes, including mortality, anastomotic leak, surgical site infections and medical complications were compared between subgroups.

Results
Of 56 175 patients undergoing rectal cancer surgery, some 6717 patients were elderly and laparoscopy was performed in 46.8 per cent of the sample. When comparing laparoscopy and open surgery in elderly patients, the operative mortality rate (1.5 versus 2.8 per cent; P &lt; 0.001), the incidence of anastomotic leakage (5.2 versus 6.5 per cent; P = 0.026), surgical site infections (6.0 versus 8.0 per cent; P = 0.001), pneumonia (1.4 versus 2.5 per cent; P = 0.001), renal failure (0.7 versus 1.3 per cent; P = 0.016) and cardiac events (0.3 versus 0.8 per cent; P = 0.008) were lower for laparoscopy than for open surgery. The overall complication rate in elderly patients (19.5 per cent) was comparable to that in the younger group (P = 0.07). However, incidence of systemic complications was significantly higher in elderly than in younger patients (all P &lt; 0.001).

Conclusion
Laparoscopy was safe and feasible in elderly patients compared with open surgery. However, the rates of systemic complications were significantly higher than in younger patients.
‘A World to Win’: In Defence of (Dissenting) Social Work—A Response to Chris Maylea
Authors: Michael Garrett Paul 
Published: January 2021

AbstractThis article is a response to Chris Maylea’s lively call to ‘end of social work’. Whilst welcoming the publication of his polemic, I maintain that there are substantial problems with his lines of analysis. Problematic facets of his article are enmeshed with questions of timing, tonality and positionality. It is also possible to identify significant evidential flaws in the bald assertion that social workers present a ‘real threat to people’. What is more, Maylea’s inadvertently risks aiding the project of the neoliberal Right. Critically engaging with the notion that there are ‘four key reasons’ necessitating the abolition of profession, I make an alternative case for reanimated and re-energised forms of ‘dissenting social work’.