bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, docking studies, and pharmacological evaluation of 2‐hydroxypropyl‐4‐arylpiperazine derivatives as serotoninergic ligands
Authors: Magli Elisa , Kędzierska Ewa , Kaczor Agnieszka A. , Bielenica Anna , Severino Beatrice , Gibuła‐Tarłowska Ewa , Kotlińska Jolanta H. , Corvino Angela , Sparaco Rosa , Esposito Giovanna , Albrizio Stefania , Perissutti Elisa , Frecentese Francesco , Leśniak Anna , Bujalska‐Zadrożny Magdalena , Struga Marta , Capasso Raffaele , Santagada Vincenzo , Caliendo Giuseppe , Fiorino Ferdinando 
Published: February 2021

AbstractA new series of norbornene and exo‐N‐hydroxy‐7‐oxabicyclo[2.2.1]hept‐5‐ene‐2,3‐dicarboximide derivatives was prepared, and their affinities to the 5‐HT1A, 5‐HT2A, and 5‐HT2C receptors were evaluated and compared with a previously synthesized series of derivatives characterized by the same nuclei, to identify selective ligands for the subtype receptors. Arylpiperazines represent one of the most important classes of 5‐HT1AR ligands, and the research of new derivatives has been focused on the modification of one or more portions of this pharmacophore. The combination of structural elements (heterocyclic nucleus, hydroxyalkyl chain, and 4‐substituted piperazine), known to be critical for the affinity to 5‐HT1A receptors, and the proper selection of substituents resulted in compounds with high specificity and affinity toward serotoninergic receptors. The most active compounds were selected for further in vivo assays to determine their functional activity. Finally, to rationalize the obtained results, molecular docking studies were performed. The results of the pharmacological studies showed that 3e, 4j, and 4n were the most active and promising derivatives for the serotonin receptor considered in this study.
Ground‐penetrating radar analysis of the Drimolen early Pleistocene fossil‐bearing palaeocave, South Africa
Authors: Armstrong Brian J. , Edwards‐Baker Stephanie , Penzo‐Kajewski Paul , Herries Andy I. R. 
Published: February 2021

AbstractThe cave systems of the Malmani Dolomite, Gauteng, South Africa, have over the decades yielded numerous specimens of Pliocene to early Pleistocene hominin fossils which are critical for our understanding of human evolution. The geomorphological and geological context of these fossils is complex. An understanding of cave formational processes coupled with effective surface and subsurface mapping of different strata and soil depths has the potential to provide new insights. A technique that has not previously been employed to the fossil sites of South Africa is the use of ground‐penetrating radar (GPR). Applied in combination with ground‐truthing data from excavations and 3D scanning and photogrammetry the combined technique highlights the capacity for GPR to help characterise various deposits. Results indicate the potential of the method to identify new void spaces, depth of colluvium as well as mapping structurally important chert bedding. This paper focuses on the Paranthropus and early Homo‐bearing cave complex of Drimolen but highlights the potential for applying these methods throughout the region.
The LUX‐ZEPLIN dark matter experiment
Authors: Parveen Nishat ,   the LZ collaboration
Published: February 2021

AbstractDark matter is one of the greatest mysteries of the Universe. The attributes of the dark matter particles, which make up about 86% of the mass of our Universe, are still obscure. LUX‐ZEPLIN (LZ) will be the most sensitive direct detection dark matter experiment to detect the faint interactions between the dark and ordinary matter. The LZ experiment employs the technology of a dual‐phase xenon time projection chamber (TPC) in combination with a novel active neutron veto to detect Weakly Interacting Massive Particles (WIMPs), one of the propitious dark matter candidates. For a 1,000 live day run, the projected spin‐independent cross‐section sensitivity of LZ is 1.6 × 10−48 cm2 for a 40 GeV c−2 mass WIMP. LZ will also probe the sensitivity to neutrinoless double beta (0νββ) decay of 136Xe. For 1,000 live days, the median exclusion sensitivity to the half‐life of 0νββ decay of 136Xe is predicted to be 1.06 × 1026 years. The LZ experiment is currently under construction and it will start commissioning by the end of 2020.
Optimal surgical margin for penile‐sparing surgery in management of penile cancer—Is 2 cm really necessary?
Authors: Anderson Elliot , Yao Henry Han‐I , Chee Justin 
Published: February 2021

AbstractIntroductionClassical teaching of a 2 cm macroscopic surgical margin for surgical treatment of primary penile cancer is overly aggressive. Contemporary evidence suggests narrow but clear margins have similar survival outcomes for localized disease. This study aims to determine the oncological outcome of using a risk‐adapted algorithm to selection of macroscopic surgical margin based on biopsy grade of disease: 5 mm margin for grade 1, 10 mm margin for grade 2, and 20 mm margin for grade 3.MethodsThis is a retrospective case series of patients who underwent penile‐sparing surgery for biopsy‐proven penile SCC by a single surgeon from May 2010 through to January 2019. Clinicopathological data were extracted from medical records. Primary outcome was the positive margin rate. Secondary outcomes were overall survival (OS), cancer‐specific survival (CSS), metastasis‐free survival (MFS), and local recurrence‐free survival (RFS). Kaplan‐Meier survival analysis was used to determine survival outcomes.ResultsA total of 21 patients were included in this study. The median age was 65. Pre‐operative biopsy grade was grade 1 in 19.1% of patients, grade 2 in 47.6%, and grade 3 in 33.3%. The median size of tumor on examination was 20 mm. Using a grade‐stratified algorithm for macroscopic surgical margin, only one patient (4.8%) had a positive margin. This patient had G1T3 disease and proceeded to have a total penectomy for oncological clearance. The median margin clearance was 7 mm. The 12‐month OS, CSS, MFS, and local RFS were 94.6%, 94.6%, 81.0%, and 92.3%, respectively.ConclusionThis study suggests that using a grade‐stratified approach to aim for a narrower macroscopic surgical margin does not appear to significantly alter the oncological outcome, with a negative margin rate of 95.2% in our this series. This enables more men to be eligible for organ preserving surgery and thereby improve their quality of life in the urinary function and sexual function domain. Larger prospective studies are warranted to confirm these findings.
Instandsetzung von chloridbelasteten Bauteilen durch Applikation einer Beschichtung
Authors: Dauberschmidt Christoph , Breit Wolfgang , Becker Felix , Celebi Ayhan 
Published: February 2021

AbstractDie im Januar 2021 eingeführte Technische Regel des Deutschen Instituts für Bautechnik (DIBt) „Instandhaltung von Betonbauwerken“ (TR‐IH) ermöglicht zwei Verfahren zur Instandsetzung von chloridbelasteten Bauwerken durch Applikation eines Oberflächenschutzsystems bei einem (weitgehenden) Belassen der Chloride im Beton. Das Instandsetzungsverfahren 7.7 „Beschichten von chloridhaltigem Beton“ kann angewendet werden, wenn der Betonstahl noch passiv ist und, u. a., die in der Betondeckung befindliche Chloridfracht einen Abstand des kritischen Chloridgehalts vom Betonstahl von 10 mm sicherstellt. Durch Entwicklung einer geschlossenen Lösung der diffusionsgesteuerten Chloridumverteilung nach Aufbringen der Beschichtung auch bei wasserteilgesättigten Betonen und einer Parameterstudie konnte gezeigt werden, dass der maximal verbleibende Chloridgehalt in der Betondeckung 2,0 M.‐%/z betragen darf. Das Instandsetzungsverfahren 8.3 „Erhöhung des elektrischen Widerstands durch Beschichtung“ darf dagegen auch bei aktiver Bewehrungskorrosion angewendet werden. Dabei wurden durch umfangreiche Untersuchungen die in der TR‐IH genannten Anwendungsgrenzen weitgehend bestätigt und hinsichtlich der Betongüte und der Art des Oberflächenschutzsystems weiter zugeschärft. Letztlich ist das Verfahren nur bei Chloridgehalten unter 1,0 M.‐%/z auch nach Chloridumverteilung mit einem geringen Risiko anwendbar.
A novel prognostic nomogram for colorectal cancer liver metastasis patients with recurrence after hepatectomy
Authors: Liang Jie‐ying , Lin Hao‐cheng , Liu Jingwen , Wang De‐shen , Yuan Yun‐fei , Li Bin‐kui , Zheng Yun , Wu Xiao‐jun , Chen Gong , Wang Feng‐hua , Wang Zhi‐qiang , Pan Zhi‐zhong , Wan De‐sen , Xu Rui‐hua , Li Yu‐hong 
Published: February 2021

AbstractPurposeWe aimed to construct a nomogram to predict personalized post‐recurrence survival (PRS) among colorectal cancer liver metastasis (CRLM) patients with post‐hepatectomy recurrence.MethodsColorectal cancer liver metastasis patients who received initial hepatectomy and had subsequent recurrence between 2001 and 2019 in Sun Yat‐sen University Cancer Center from China were included in the study. Patients were randomly assigned to a training cohort and a validation cohort on a ratio of 2:1. Univariable analysis was first employed to select potential predictive factors for PRS. Then, the multivariable Cox regression model was applied to recognize independent prognostic factors. According to the model, a nomogram to predict PRS was established. The nomogram's predictive capacity was further assessed utilizing concordance index (C‐index) values, calibration plots, and Kaplan–Meier curves.ResultsAbout 376 patients were finally enrolled, with a 3‐year PRS rate of 37.3% and a 5‐year PRS rate of 24.6%. The following five independent predictors for PRS were determined to construct the nomogram: the largest size of liver metastases at initial hepatectomy, relapse‐free survival, CEA level at recurrence, recurrent sites, and treatment for recurrence. The nomogram displayed fairly good discrimination and calibration. The C‐index value was 0.742 for the training cohort and 0.773 for the validation cohort. Patients were grouped into three risk groups very well by the nomogram, with 5‐year PRS rates of 45.2%, 23.3%, and 9.0%, respectively (p < 0.001) in the training cohort and 36.0%, 9.2%, and 4.6%, respectively (p < 0.001) in the validation cohort.ConclusionA novel nomogram was built and validated to enable the prediction of personal PRS in CRLM patients with post‐hepatectomy recurrence. The nomogram may help physicians in decision making.
Disparities in colorectal cancer screening among breast and prostate cancer survivors
Authors: Dash Chiranjeev , Lu Jiachen , Parikh Vicky , Wathen Stacey , Shah Samay , Shah Chaudhari Ruchi , Adams‐Campbell Lucile 
Published: February 2021

ABSTRACTBackgroundColorectal cancer (CRC) screening is recommended as an integral part of cancer survivorship care. We compared the rates of CRC screening among breast and prostate cancer survivors by primary cancer type, patient, and geographic characteristics in a community‐based health‐care system with a mix of large and small metro urban areas.Materials and MethodsData for this retrospective study were abstracted from medical records of a multi‐specialty practice serving about 250,000 individuals in southern Maryland. Breast (N = 1056) and prostate (N = 891) cancer patients diagnosed prior to 2015 were followed up till June 2018. Screening colonoscopy within the last 10 years was considered to be guideline concordant. Multivariate logistic regression was used to determine the prevalence odds ratios of being concordant on CRC screening by age, gender, race, metro area type, obesity, diabetes, and hypertension.ResultsOverall 51% of survivors had undergone a screening colonoscopy. However, there was a difference in CRC screening rate between prostate (54%) and breast (44%) cancer survivors. Older age (≥65 years), being a breast cancer survivor compared to prostate cancer, and living in a large compared to small metropolitan area were associated with a lower probability of receiving CRC screening. Having hypertension was associated with higher likelihood of being current on colonoscopy screening guidelines among survivors; but diabetes and obesity were not associated with CRC screening.ConclusionsLow levels of CRC screening utilization were found among breast and prostate cancer survivors in a single center in Southern Maryland. Gender, comorbidities, and residential factors were associated with receipt of CRC screening.
Effect of antitumor therapy on cancer patients infected by SARS‐CoV‐2: A systematic review and meta‐analysis
Authors: Li Piao , Li Lingling , Wang Shennan , Liu Yu , Li Zhou , Xia Shu 
Published: February 2021

AbstractBackgroundCancer patients are at a high risk of being infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), and are more likely to develop severe illness and have higher mortality once infected. In the COVID‐19 pandemic, it is urgent to understand the effects of antitumor therapy on the prognosis of patients with COVID‐19.MethodsA systematic literature search was conducted in PubMed, Cochrane Library, Embase, MedRxiv, and Chinese National Knowledge Infrastructure (CNKI) until 21 June 2020. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were evaluated using a random effects model to analyze the effects of antitumor therapies on COVID‐19 patients.ResultsFor cancer patients with COVID‐19, the death events related to antitumor treatment were higher than those with no antitumor treatment (OR = 1.55; 95% CI 1.07–2.25; p = 0.021). Compared with patients in the survival group, the non‐survival group showed no significant differences in patients who received antitumor therapy. Compared with patients in the non‐severe group, the severe group was more likely to receive antitumor therapy (OR = 1.50; 95% CI 1.02–2.19; p = 0.037) and there was a significant difference. The incidence of severe events was higher in the subgroup of chemotherapy (OR = 1.73; 95% CI 1.09–2.73).ConclusionThe synthesized evidence suggests that cancer patients with COVID‐19 who received antitumor treatment shortly before symptom onset are more likely to experience severe symptoms and have high mortality. Receiving chemotherapy is an unfavorable factor for the prognosis of cancer patients with COVID‐19.
Circ‐UBAP2 functions as sponges of miR‐1205 and miR‐382 to promote glioma progression by modulating STC1 expression
Authors: Wang Jianxin , Li Tianxiao , Wang Bin 
Published: February 2021

AbstractBackgroundCircular RNAs (circRNAs) exert vital functions in glioma pathogenesis. CircRNA ubiquitin‐associated protein 2 (circ‐UBAP2, hsa_circ_0008344) has been illuminated as a tumor driver in glioma. Nevertheless, the mechanisms underlying the oncogenic regulation of circ‐UBAP2 in glioma are still undefined.MethodsCirc‐UBAP2, miR‐1205, miR‐382, and GPRC5A were quantified using qRT‐PCR and western blot. Cell viability was detected using a CCK‐8 assay. Cell migration and invasion were measured using the would‐healing and transwell assays. Flow cytometry and colony formation assay were applied to evaluate cell apoptosis and colony formation, respectively. The xenograft model assays were used to examine the impact of circ‐UBAP2 on tumorigenic effect in vivo. Direct relationships among circ‐UBAP2, miR‐1205, miR‐382, and GPRC5A were confirmed using dual‐luciferase reporter assays.ResultsCirc‐UBAP2 expression was upregulated in glioma. The reduced level of circ‐UBAP2 hampered cell proliferation, migration, invasion, and enhanced apoptosis in vitro and weakened tumor growth in vivo. Mechanistically, circ‐UBAP2 directly bound to miR‐1205 and miR‐382. miR‐1205 and miR‐382 mediated the regulation of circ‐UBAP2 silencing on glioma cell behaviors. Moreover, GPRC5A was a functional target of miR‐1205 and miR‐382 in regulating glioma cell behaviors. Furthermore, circ‐UBAP2 mediated GPRC5A expression through miR‐1205 or miR‐382 in glioma cells.ConclusionOur current findings identified that circ‐UBAP2 silencing impeded glioma malignant progression partially by downregulating GPRC5A through targeting miR‐1205 and miR‐382.
Sex difference in long‐term clinical outcomes after percutaneous coronary intervention: A propensity‐matched analysis of National Health Insurance data in Republic of Korea
Authors: Lee Seung‐Hwa , Choi Jungmin , Chang Yoo‐Jung , Shin Eun‐Seok , Choi Ki‐Hong , Lee Joo Myung , Park Taek Kyu , Yang Jeong Hoon , Song Young Bin , Hahn Joo‐Yong , Choi Seung‐Hyuk , Gwon Hyeon‐Cheol , Lee Sang‐Hoon , Choi Jin‐Ho 
Published: February 2021

AbstractObjectiveWe investigated the gender difference in the 5‐year outcome after percutaneous coronary intervention (PCI) using an unselected population data.BackgroundSex‐specific outcome after percutaneous coronary intervention (PCI) is not consistent among studies.MethodsA total of 48,783 patients were enrolled from a Korean nationwide cohort of PCI in year 2011. Outcomes adjusted with age and propensity for clinical characteristics were compared. Primary outcome was 5‐year cumulative incidence of all‐cause death. Nonfatal major adverse clinical event (MACE) consisting of revascularization, shock, or stroke was also assessed.ResultsIn unadjusted analysis, women were older and had higher frequency of comorbidities including hypertension, hyperlipidemia, and diabetes compared to men (p < .001, all). Women had higher 5‐year death risk than men (21.8 vs. 17.3%; hazard ratio [HR] 1.29, 95% confidential interval [CI] 1.23–1.34). In propensity score‐matched analysis (N = 28,924), women had lower 5‐year death risk (20.2 vs. 26.1%, HR 0.75, 95% CI 0.71–0.78). This lower death risk in women was consistent in subgroup analyses of age, risk factors, and clinical diagnosis including angina or acute myocardial infarction (p < .05, all).ConclusionsOlder age and more common comorbidities in women contributed to the apparent worse outcome after PCI in women. After adjusting these disadvantages, women had better outcome after PCI than men.
Effect of acid‐soluble wheat protein addition on the quality of bread prepared from molded frozen dough
Authors: Arai Chiaki , Hirose Rieko , Tozaki Mikiko , Nakamura Satoshi , Yamaguchi Satoshi , Suzuki Minoru , Miyamori Kiyokatsu , Noguchi Tomohiro , Takano Katsumi 
Published: February 2021

AbstractBackgrounds and objectivesThe structure of molded frozen dough cannot be reconstructed before baking; therefore, molding directly affects bread quality. The effect of the addition of acid‐soluble wheat protein (ASP), which consists mainly of gliadin, to molded frozen dough on molding conditions was examined.FindingsMolded (unfermented) frozen dough samples were prepared from the same dough batch at different floor times (assumed potential time differences during dividing). Scanning electron microscopy revealed the presence of cracks in the microstructure of the molded dough. The cracks were caused by gluten damage owing to changes in rheological properties and appeared when the floor time was extended from 5 to 20 min. The addition of ASP maintained the uniformity of the gluten sheet regardless of floor time.ConclusionsThe added ASP increased shape uniformity of bread rolls prepared from molded frozen dough and also crumb grain structure and crust appearance uniformity.Significance and noveltyThe addition of ASP to molded frozen dough improved bread quality and prevented manufacturing problems that can occur during mechanized bread‐making. Therefore, we anticipate that ASP could also be added to pre‐fermented and par‐baked frozen doughs.
Unexpected urological presentation of COVID‐19 in a 41‐year‐old female: A case report
Authors: Haghighi Ramin , Hashemi Seyed Ahmad , Abaszade Ganji Ali , Haghighi Ashkan , Mollazadeh Samaneh 
Published: February 2021

AbstractHematuria and urinary discomfort may be the first manifestations of COVID‐19 infection. Nevertheless, more researches are needed to be done in this field to clarify the exact mechanism by which SARS‐CoV‐2 affects the urological system.
Serum progranulin level is a novel tool for monitoring disease activity of dermatomyositis with antimelanoma differentiation‐associated protein 5 antibodies
Authors: Fujii Asami , Mizutani Yuki H. , Kawamura Miho , Matusyama Kanako , Mizutani Yoko , Shu En , Seishima Mariko 
Published: February 2021

AbstractObjectivesDermatomyositis (DM) is an autoimmune disease that presents with a wide variety of clinical manifestations. Patients with DM or clinically amyopathic dermatomyositis (CADM) with antimelanoma differentiation‐associated protein 5 (anti‐MDA5) antibodies are frequently associated with interstitial pneumonia, especially rapidly progressive interstitial lung disease. Progranulin (PGRN) is an autocrine growth factor involved in inflammation. Elevated serum PGRN levels have been reported in the patients with systemic lupus erythematosus and rheumatoid arthritis. However, they have not been precisely studied in DM/CADM. We assessed PGRN levels as a potential biomarker for DM/CADM with anti‐MDA5 antibodies.MethodsTwenty‐four DM/CADM patients with anti‐MDA5 antibodies, 12 patients without anti‐MDA5 antibodies, and eight healthy volunteers were enrolled. We measured serum PGRN levels and compared them between the anti‐MDA5 antibody‐positive and antibody‐negative groups. They were also measured before and after the start of treatment in anti‐MDA5 antibody‐positive patients. We examined the correlations between serum PGRN levels and laboratory data such as serum KL‐6 and ferritin levels.ResultsPatients with DM/CADM, especially those with anti‐MDA5 antibodies, had significantly higher serum PGRN levels than healthy individuals. They decreased after the start of treatment. Serum PGRN levels were positively correlated with serum KL‐6 and ferritin levels, and anti‐MDA5 antibody titers.ConclusionsThis is the first study to show that PGRN levels were significantly elevated in the sera of DM/CADM patients, particularly in those with anti‐MDA5 antibodies. PGRN may be a useful biomarker of disease activity. However, further studies are required to reveal the mechanisms of PGRN in DM/CADM more precisely.
Lüften, wenn der Sensor anschlägt
Authors: Kegele Johann , Altmann Frank 
Published: February 2021

AbstractDas Coronavirus verbreitet sich unter anderem durch Tröpfcheninfektionen und Aerosole. Dabei lässt sich eine mögliche Ansteckungsgefahr in Innenräumen durch rechtzeitiges, regelmäßiges und ausreichendes Lüften deutlich verringern. Was im Sommer noch angen
Eine einfache Sache, aber…
Authors: Aust Alexander 
Published: February 2021

AbstractDie Überdruckkapselung ist eine effektive Methode, um elektrische Betriebsmittel bei der Verwendung in explosionsgefährdeten Bereichen zu schützen. Trotz der simplen Handhabung bedarf es vor dem Einsatz dieser Technik jedoch einer professionellen Planung.