bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatal intoxication with U-47700 in combination with other NPS (N-ethylhexedrone, adinazolam, 4-CIC, 4-CMC) confirmed by identification and quantification in autopsy specimens and evidences
Authors: Nowak Karolina , Szpot Paweł , Zawadzki Marcin 
Published: January 2021

Abstract
Purpose
We present a case of fatal intoxication with U-47700 in combination with other NPS (N-ethylhexedrone, adinazolam, 4-chloro-N-isopropylcathinone (4-CIC), 4-chloromethcathinone (4-CMC) and sertraline) confirmed by identification and quantification in biological materials and evidences found at the scene in 2017 in Poland.

Methods
Blood and urine samples were extracted with ethyl acetate from alkaline medium (pH 9); powders/crystals were diluted with methanol. The analysis was carried out using ultra-high-performance liquid chromatography–tandem mass spectrometry. Validation criteria were evaluated for blood and urine at the concentrations of 10 and 100 ng/mL.

Results
The validation parameters of the method were within acceptable ranges. In the presented case, the determined concentrations of drugs were as follows, in blood: U-47700, 1470 ng/mL; N-ethylhexedrone, 58 ng/mL; adinazolam, 18 ng/mL; 4-CIC, 8.0 ng/mL; 4-CMC, 1.7 ng/mL; in urine: U-47700, 3940 ng/mL; N-ethylhexedrone, 147 ng/mL; adinazolam, 82 ng/mL; 4-CIC, 130 ng/mL; 4-CMC, 417 ng/mL. Sertraline (blood, 89 ng/mL; urine, 32 ng/mL) was also determined in both materials. The same substances were also found in 5 powders/crystals: U-47700 (12% by weight), N-ethylhexedrone (54%), adinazolam (14%), 4-CIC (23%), 4-CMC (26%). After 775 days of storage, biological samples at + 4 °C, the most stable substance was sertraline and the less, synthetic cathinones, especially 4-CIC and 4-CMC.

Conclusions
The described case of fatal intoxication with NPS presented postmortem concentrations of U-47700, 4-CMC, N-ethylhexedrone, adinazolam and 4-CIC for the first time in the literature. The paper also showed stability study of these substances stored at + 4 °C for 775 days.
Inner transformation to sustainability as a deep leverage point: fostering new avenues for change through dialogue and reflection
Authors: Woiwode Christoph , Schäpke Niko , Bina Olivia , Veciana Stella , Kunze Iris , Parodi Oliver , Schweizer-Ries Petra , Wamsler Christine 
Published: January 2021

AbstractThis article provides a rationale for inner transformation as a key and hitherto underresearched dimension of sustainability transformations. Inner transformation relates to various aspects of human existence and interactions such as consciousness, mindsets, values, worldviews, beliefs, spirituality and human–nature connectedness. The article draws on Meadows’ leverage points approach, as places to intervene in a system, to reveal the relevance of inner transformation for system change towards sustainability. Based on insights from a series of dialogue and reflection workshops and a literature review, this article provides three important contributions to sustainability transformations research: first, it increases our conceptual understanding of inner transformation and its relevance for sustainability; second, it outlines concrete elements of the inner transformation-sustainability nexus in relation to leverage points; and third, it presents practical examples illustrating how to work with leverage points for supporting inner transformation. In sum, the paper develops a systematized and structured approach to understanding inner transformation, including the identification of deep, i.e., highly influential, leverage points. In addition, it critically discusses the often contentious and divergent perspectives on inner transformation and shows related practical challenges. Finally, current developments in inner transformation research as well as further research needs are identified.
Serum inhibin B for differentiating between congenital hypogonadotropic hypogonadism and constitutional delay of growth and puberty: a systematic review and meta-analysis
Authors: Gao Yuting , Du Qin , Liu Liyi , Liao Zhihong 
Published: January 2021

Abstract
Purpose
The distinction between congenital hypogonadotropic hypogonadism (CHH) and constitutional delay of growth and puberty (CDGP) in patients with delayed puberty is difficult to distinguish, but important for timely treatment. The aim of this study is to perform a systematic review and meta-analysis to determine the diagnostic performance of serum inhibin B (INHB) levels for differentiating CHH and CDGP.

Methods
PubMed, EMBASE, and Cochrane Library databases were systematically searched from the date of database inception to November 10, 2019 for studies examining the use of serum INHB to discriminate between CHH and CDGP. Pooled odds ratios (OR), sensitivity, specificity, and 95% confidence intervals (CI) were calculated. The Quality Assessment of Diagnostic Studies-2 (QUADAS-2) was used to assess the quality of the included studies. Sub-analyses were performed including that based on testicular volume (TV) and study design.

Results
Seven studies, comprising of 349 patients (96 CHH and 253 CDGP), were included in the meta-analysis. For differentiating between CHH and CDGP, INHB level exhibited good diagnostic accuracy with a pooled sensitivity of 92% (95% confidence interval [CI]: 0.86–0.96, I2 = 0.4%, p = 0.4343), specificity of 92% (95% CI: 0.88–0.94, I2 = 68.1%, p = 0.0009), and pooled area under the receiver operating characteristic curve (AUC) of 0.9619. The cut-off values of INHB for boys were 56, 66, 80, 96, 94.7, 111, and 113 pg/ml (assay method standardized to Gen II ELISA). Sub-analyses showed that testicular volume and study design could be a source of statistically significant heterogeneity in specificity. In boys with a testicular volume of ≤3 ml, INHB performed well with a sensitivity of 92%, specificity of 98%, and AUC of 0.9956.

Conclusion
INHB exhibits excellent diagnostic efficiency in distinguishing CHH from CDGP, especially in boys with severe puberty deficiency (TV ≤ 3 ml).
On the Adaptive Value of Paranormal Beliefs - a Qualitative Study
Authors: Betsch Tilmann , Jäckel Paul , Hammes Mareike , Brinkmann Babette Julia 
Published: January 2021

AbstractTen female and five male participants (age range 28–50 years) were recruited at esoteric fairs or via esoteric chatrooms. In a guided face-to-face interview, they reported origins and contents of their beliefs in e.g. esoteric practices, supernatural beings, rebirthing, channeling. Transcripts of the tape-recorded reports were subjected to a qualitative analysis. Exhaustive categorization of the narratives’ content revealed that paranormal beliefs were functional with regard to two fundamental motives – striving for mastery and valuing me and mine (striving for a positive evaluation of the self). Moreover, paranormal beliefs paved the way for goal-setting and leading a meaningful life but, on the negative side, could also result in social exclusion. Results are discussed with reference to the adaptive value of paranormal beliefs.
Lay theories of grandiose and vulnerable narcissism
Authors: Koepernik Tatjana , Jauk Emanuel , Kanske Philipp 
Published: January 2021

AbstractIn public discourse, narcissism is often portrayed one-sidedly and overly negative, rendering a picture of narcissistic individuals as “toxic people” or “evil characters”. Beyond these salient associations, psychological theories point to a more complex phenomenon, and different developmental mechanisms are being discussed in relation to it. We investigated the prevalence of different implicit theories on narcissism including beliefs about its developmental antecedents. We put forward the question whether grandiose and vulnerable narcissistic behaviors are regarded as congruent or incongruent expressions of underlying feelings and motives, that is whether grandiose behavior is attributed to underlying grandiosity or underlying vulnerability, and vice versa. Results of an online survey (N = 177) show higher agreement with congruent rather than incongruent theories (i.e., grandiose narcissism is attributed to feelings of superiority rather than inferiority, vulnerable narcissism is attributed to inferiority rather than superiority). In line with this, participants displayed predominant beliefs in parental overvaluation as a developmental antecedent of grandiose narcissism/parental coldness as an antecedent of vulnerable narcissism. With higher self-reported prior knowledge of narcissism, endorsement of theories assuming incongruencies increased. The likability of narcissism was not associated with endorsement of the different implicit theories, but instead with perceivers’ own narcissism levels. Results suggest that laypeople employ an “it is what it seems” – heuristic facing both grandiose and vulnerable narcissistic behaviors and are less likely to attribute grandiose or vulnerable behavior to incongruent motivational states. Findings might help to better understand the public image of narcissism and its social consequences.
Development and characterization of an all-in-one gamma probe with auto-peak detection for sentinel lymph node biopsy based on NEMA NU3-2004 standard
Authors: Radnia Aram , Abdollahzadeh Hamed , Teimourian Behnoosh , Farahani Mohammad Hossein , Akbari Mohammad Esmaeil , Zaidi Habib , Ay Mohammad Reza 
Published: January 2021

Abstract
Background
A gamma probe is a handheld device used for intraoperative interventions following interstitial injection of a radiotracer to locate regional lymph nodes through the external detection of radiation. This work reports on the design and performance evaluation of a novel fully integrated gamma probe (GammaPen), recently developed by our group.

Materials and methods
GammaPen is an all-in-one pocket gamma probe with low weight and adequate dimensions, consisting of a detector, a control unit and output all together. The detector module consists of a cylindrical Thallium-activated Cesium Iodide [CsI (Tl)] crystal optically coupled to a Silicon photomultiplier (SiPM), shielded using Tungsten housing on side and back faces. The electronics of the probe consists of two small boards to handle signal processing and analog peak detection tasks. A number of parameters, including probe sensitivity in air/water, spatial resolution in air/water, angular resolution in air/water, and side and back shielding effectiveness, were measured to evaluate the performance of the probe based on NEMA NU3-2004 standards.

Results
The sensitivity of the probe in air at distances of 10, 30, and 50 mm is 18784, 3500, and 1575 cps/MBq. The sensitivity in scattering medium was also measured at distances of 10, 30, and 50 mm as 17,680, 3050, and 1104 cps/MBq. The spatial and angular resolutions in scattering medium were 47 mm and 87 degree at 30 mm distance from the probe, while they were 40 mm and 77 degree in air. The detector shielding effectiveness and leakage sensitivity are 99.91% and 0.09%, respectively.

Conclusion
The performance characterization showed that GammaPen can be used effectively for sentinel lymph node localization. The probe was successfully used in several surgical interventions by an experienced surgeon confirming its suitability in a clinical setting.
Method Development and Determination of Chlorinated Polycyclic Aromatic Hydrocarbons in Different Matrices
Authors: Schörnick Carsten , Lüth Anja , Wobst Birgit , Rotard Wolfgang 
Published: January 2021

AbstractThe aim of this study was to develop an analytical method, which separates selected chlorinated polycyclic aromatic hydrocarbons (Cl-PAHs) from fat, and fat-free or vegetable matrices. The method contains extraction-, cleanup-, and quantification steps. Integration of automated analysis actions, as in extraction and cleanup, should enhance the reproducibility, precision, and efficiency of the method. This was confirmed by validation of the overall analytical process. In the end, as a performance check, the developed method was applied on different matrices, e.g., tea, rice, grilled pork, and eel and predator eggs, as a non-food example. An inter-laboratory check was initiated as replacement for the lack of proficiency tests. Due to the high level of automation, both personnel and time effort are very low. In addition, the method is very robust with regard to the variability of the solvent selection and the loss of analytes by evaporation to dryness. It could be demonstrated that the developed method is applicable to different matrices with reproducible and precise results. This applies also to low-fat food and feed.
Characteristics of interstitial lung disease in patients from post-marketing data on metastatic breast cancer patients who received abemaciclib in Japan
Authors: Chen Yucherng , Noma Satoshi , Taguchi Yoshio , Takahashi Masashi , Tsurutani Junji , Mori Shiho , Sakaguchi Sachi , Asou Hiroya , Tomii Keisuke 
Published: January 2021

Abstract
Background
This study evaluated characteristics of patients treated with abemaciclib and diagnosed with interstitial lung disease (ILD), using 12-month post-marketing data from the real-world setting in Japan.

Methods
Spontaneous reports of adverse events in patients receiving abemaciclib were collected regularly from healthcare providers (HCPs) from November 30, 2018, to November 29, 2019. Detailed follow-up was requested on suspected ILD cases via questionnaires and/or interviews. Radiological images (when available) were reviewed by an ILD adjudication committee of specialists. The age distribution of patients prescribed abemaciclib in Japan was estimated based on insurance claims data.

Results
Of 4700 patients estimated to be exposed to abemaciclib, 82 cases of ILD were reported (46 serious, 13 fatal). Most (91%) had ≥ 1 symptom at diagnosis, commonly dyspnea/shortness of breath (59%), cough (44%), and/or fever (37%). The majority (68%) received steroid therapy (24 [56%] recovered/recovering; 5 [12%] not recovered; 13 [30%] deaths, 1 [2.3%] unknown). No specific imaging patterns or sites of predilection were identified, but a diffuse alveolar damage (DAD) pattern was observed at outcome in 3 of 4 evaluated fatal cases (16 in total evaluated). Features of fatal cases included advanced age, pre-existing interstitial change, and advanced Eastern Cooperative Oncology Group Performance Status.

Conclusion
Advanced age and a DAD pattern were identified as potential risk factors for cases with poorer outcomes, as previously reported for drug-induced ILD. HCPs should consider the benefit–risk profile when prescribing abemaciclib, informing patients of risks and regularly monitoring treated patients to ensure early detection and treatment of ILD.
The best of all possible coexistence
Authors: Fortelius Mikael , Myrdal Peter , Zliobaite Indre 
Published: January 2021

AbstractThe writings of Gottfried Wilhelm Leibniz (1646–1716) provide a window on early evolutionary thinking of a kind interestingly different from the roots of modern evolutionary theory as it emerged in the years following the French Revolution. Here we relate aspects of Leibniz’s thinking to methods of modern palaeoecology and show that, despite a different terminology and a different hierarchic focus, Leibniz emerges as a strikingly modern theoretician, who viewed the living world as dynamic and capable of adaptive change. The coexistence approach of palaeoecological reconstruction, developed by Volker Mosbrugger and collaborators, with its core assumption of harmoniously co-adapted communities with strong historical legacy, represents, in a positive sense, a more Leibnizian view than functionally based and theoretically history-free approaches, such as ecometrics. Recalling Leibniz’s thinking helps to highlight how palaeoecological reconstruction is about much more than reliably establishing the ecological and climatic situation of a given fossil locality. While reliable reconstructions of past conditions are certainly of great value in research, it is arguably the need to think deeply about how the living world really works that keeps palaeoecological reconstruction such a long-running and central aspect of evolutionary science. And while we struggle to understand the coexistence and dynamic interaction of endless levels of living agents of the living world, simultaneously large and small, global and local, the coexistence approach of palaeoecological reconstruction remains both an outstandingly operational method and part of a philosophical tradition reaching back to the very earliest evolutionary thinking.
Comparative evaluation of concrete sand-control fences used for railway protection in strong wind areas
Authors: Shi Long , Wang Dongyuan , Cui Kai , Xue Chunxiao 
Published: January 2021

AbstractConcrete-plate fences have been widely adopted for windblown sand control and mitigation along railways. However, the inclination angles of inserting the concrete plate with respect to the vertical direction, i.e., straight or obliquely inserted concrete plates (SIP or OIP), significantly influence the efficiency of sand-control. This study performs a comparative evaluation of the SIP and OIP sand-control fences using wind tunnel testing and field monitoring data collected from the Lanzhou–Wulumuqi High-Speed Railway Project. The results show that the fence’s ability to reduce the wind speed and the sand-retaining efficiency gradually weakens with the increasing wind speed. Compared with the SIP fence, the OIP fence has a better wind speed reduction capability, stronger ability to capture fine particles below the top of the fence; it is more efficient for sand-retaining and induces stronger eddy intensity. Generally, the wind tunnel test and field monitoring results are consistent, whereas wind tunnel tests incline to overestimate wind speed reduction and sand-control efficiency. The study also finds that the aeolian sand accumulated around the fence can weaken the protection efficiency, and hence cleaning the aeolian sand accumulated around the fence should be done periodically to ensure the designed functions.
Gold Nanostars-AIE Theranostic Nanodots with Enhanced Fluorescence and Photosensitization Towards Effective Image-Guided Photodynamic Therapy
Authors: Tavakkoli Yaraki Mohammad , Wu Min , Middha Eshu , Wu Wenbo , Daqiqeh Rezaei Soroosh , Liu Bin , Tan Yen Nee 
Published: January 2021

AbstractDual-functional aggregation-induced photosensitizers (AIE-PSs) with singlet oxygen generation (SOG) ability and bright fluorescence in aggregated state have received much attention in image-guided photodynamic therapy (PDT). However, designing an AIE-PS with both high SOG and intense fluorescence via molecular design is still challenging. In this work, we report a new nanohybrid consisting of gold nanostar (AuNS) and AIE-PS dots with enhanced fluorescence and photosensitization for theranostic applications. The spectral overlap between the extinction of AuNS and fluorescence emission of AIE-PS dots (665 nm) is carefully selected using five different AuNSs with distinct localized surface plasmon (LSPR) peaks. Results show that all the AuNSs can enhance the 1O2 production of AIE-PS dots, among which the AuNS with LSPR peak at 585 nm exhibited the highest 1O2 enhancement factor of 15-fold with increased fluorescence brightness. To the best of our knowledge, this is the highest enhancement factor reported for the metal-enhanced singlet oxygen generation systems. The Au585@AIE-PS nanodots were applied for simultaneous fluorescence imaging and photodynamic ablation of HeLa cancer cells with strongly enhanced PDT efficiency in vitro. This study provides a better understanding of the metal-enhanced AIE-PS nanohybrid systems, opening up new avenue towards advanced image-guided PDT with greatly improved efficacy.
Cavitation patterns in high-pressure homogenization nozzles with cylindrical orifices: Influence of mixing stream in Simultaneous Homogenization and Mixing
Authors: Gall V. , Rütten E. , Karbstein H. P. 
Published: January 2021

AbstractHigh-pressure homogenization is the state of the art to produce high-quality emulsions with droplet sizes in the submicron range. In simultaneous homogenization and mixing (SHM), an additional mixing stream is inserted into a modified homogenization nozzle in order to create synergies between the unit operation homogenization and mixing. In this work, the influence of the mixing stream on cavitation patterns after a cylindrical orifice is investigated. Shadow-graphic images of the cavitation patterns were taken using a high-speed camera and an optically accessible mixing chamber. Results show that adding the mixing stream can contribute to coalescence of cavitation bubbles. Choked cavitation was observed at higher cavitation numbersσwith increasing mixing stream. The influence of the mixing stream became more significant at a higher orifice to outlet ratio, where a hydraulic flip was also observed at higherσ. The decrease of cavitation intensity with increasing back-pressure was found to be identical with conventional high-pressure homogenization. In the future, the results can be taken into account in the SHM process design to improve the efficiency of droplet break-up by preventing cavitation or at least hydraulic flip.
The Inventory Routing Problem with Demand Moves
Authors: Baller Annelieke C. , Dabia Said , Desaulniers Guy , Dullaert Wout E. H. 
Published: January 2021

AbstractIn the Inventory Routing Problem, customer demand is satisfied from inventory which is replenished with capacitated vehicles. The objective is to minimize total routing and inventory holding cost over a time horizon. If the customers are located relatively close to each other, one has the opportunity to satisfy the demand of a customer by inventory stored at another nearby customer. In the optimization of the customer replenishments, this option can be included to lower total costs. This is for example the case for ATMs in urban areas where an ATM-user that wants to withdraw money could be redirected to another ATM. To the best of our knowledge, the possibility of redirecting end-users is new to the operations research literature and has not been implemented, but is being considered, in the industry. We formulate the Inventory Routing Problem with Demand Moves in which demand of a customer can (partially) be satisfied by the inventory of a nearby customer at a service cost depending on the quantity and the distance. We propose a branch-price-and-cut solution approach which is evaluated on problem instances from the literature. Cost improvements over the classical IRP of up to 10% are observed with average savings around 3%.