bluuebunny/crossref_metadata_2025_split huggingface dataset:
A PROPORCIONALIDADE DA LEI DO ABATE
Authors: Mantuani Matheus 
Published: October 2021

O presente artigo visa dissecar criticamente a chamada Lei do Abate (Lei n.º 9614/98), assim conhecida devido à possibilidade de, em seu uso, derrubar-se aeronaves, independentemente destas estarem ou não com homens a bordo. Utilizou-se aqui o método de ponderação à moda alemã através do chamado princípio da proporcionalidade e seus subprincípios. Munido da necessária filtragem constitucional, pôde-se constatar da invalidade da supracitada Lei perante o ordenamento jurídico brasileiro: resta importante a perda de sua eficácia.

Palavras-chave: Lei do Abate. Juízo de Proporcionalidade. Fórmula de Radbruch.
Anlotinib-Induced Hypertension: Current Concepts and Future Prospects
Authors: Lv Bing , Chen Jing , Liu Xiao-Liang 
Published: October 2021

Background:
Anlotinib is a new tyrosine kinase inhibitor developed in China that targets the receptors
for vascular endothelial growth factor, platelet-derived growth factor, fibroblast growth factor, and stem
cell factor. Therefore, anlotinib inhibits tumor angiogenesis, representing a new therapeutic alternative for lung
cancer. Hypertension is one of its most common adverse effects, leading to discontinuation of the drug and
limited clinical usefulness.

Objective:
The present review aims to summarize the evidence on the prevalence, physiopathology, and management
of anlotinib-induced hypertension, as well as its effect on the cancer prognosis.

Method:
Searches in Medline, Cochrane Central Library, and Embase were performed using the following
terms: anlotinib, adverse effect, hypertension, clinical trial, vascular endothelial growth factor, and anti-angiogenic
drugs. Citations were also identified by checking the reference sections of selected papers.

Results:
Except for a phase I clinical trial with a small sample size (n = 6), almost all the clinical trials on anlotinib
have reported the development of anlotinib-induced hypertension. In these trials, the incidence of hypertension
ranged from 13% to 67.7%, and that of grade 3/4 hypertension ranged from 4.8% to 16%. Alterations in nitric
oxide, endothelin-1, microvascular rarefaction, selective vasoconstrictions, and renal injury have been cited
as potential mechanisms leading to anlotinib-induced hypertension. When needed, treatment may include general
hygienic measures and pharmacotherapy in some cases.

Conclusions:
To effectively manage anlotinib-induced hypertension, early prevention, a reasonable dosage regimen,
and appropriate treatment are critical to effectively manage anlotinib-induced hypertension. Additionally,
anlotinib-induced hypertension may be considered a marker for predicting efficacy.
Repurposing Drugs to Combat Drug Resistance in Leprosy: A Review of
Opportunities
Authors: Singh Pushpendra , Sharma Mukul 
Published: October 2021

Abstract:
Leprosy is caused by extremely slow-growing and uncultivated mycobacterial pathogens,
namely Mycobacterium leprae and M. lepromatosis. Nearly 95% of the new cases of leprosy
recorded globally are found in India, Brazil, and 20 other priority countries (WHO, 2019), of
which nearly two-third of the cases are reported in India alone. Currently, leprosy is treated with
dapsone, rifampicin, and clofazimine, also known as multi-drug therapy (MDT), as per the recommendations
of WHO since 1981. Still, the number of new leprosy cases recorded globally has remained
constant in last one-decade, and resistance to multiple drugs has been documented in various
parts of the world, even though relapses are rare in patients treated with MDT. Antimicrobial
resistance testing against M. leprae or the evaluation of the anti-leprosy activity of new drugs remains
a challenge as leprosy bacilli cannot grow in vitro. Besides, developing a new drug against
leprosy through conventional drug development process is not economically attractive or viable for
pharma companies. Therefore, a promising alternative is the repurposing of existing
drugs/approved medications or their derivatives for assessing their anti-leprosy potential. It is an
efficient method to identify novel medicinal and therapeutic properties of approved drug molecules.
Any combinatorial chemotherapy that combines these repurposed drugs with the existing
first-line (MDT) and second-line drugs could improve the bactericidal and synergistic effects
against these notorious bacteria and can help in achieving the much-cherished goal of “leprosy-free
world”. This review highlights novel opportunities for drug repurposing to combat resistance to
current therapeutic approaches.
The Synthesis and Chemistry of Quinolinediones and their Carbocyclic
Analogs
Authors: Egu Samuel Attah , Onoabedje Efeturi Abraham , Okoro Uchechukwu Chris , Khan Khalid Mohammed , Hameed Abdul , Ali Irfan , Iftekhar Shafia , Odin Eboh Monday , Shamim Shahbaz 
Published: October 2021

Abstract:
Quinoline-5,8-dione and naphthoquinone nuclei are very important substructures in industrial
chemicals and pharmaceuticals. These compounds exhibit a wide variety of activities, including
antifungal, antibacterial, antimalarial, antineoplastic, anticoagulant, anticancer, antiviral, radical scavenging,
antiplatelet, trypanocidal, cytotoxic, and antineoplastic activities. Currently, several research
articles on the importance of many natural and synthetic drugs containing quinolinequinone have
been reported. This review covers the progress in quinolinequinone and naphthoquinone chemistry
over the last five decades.
Development of a Quality Index Method Scheme for Sensory Assessment
of Chilled Yellowfin Tuna
Authors: Mai Nga T.T. , Olanrewaju Akin Y. , Le Luan V. 
Published: October 2021

Background:
Quality monitoring and/or assessment are parts of a freshness/quality
control system, which is of utmost importance for fresh seafood, especially Scombridae fish.
The quality index method (QIM) is a simple, convenient, unique, and reliable tool to determine
the sensory status and estimate the remaining shelf life of aqua products.

Objective:
This study aimed to develop a QIM scheme for chilled stored yellowfin tuna and
apply the protocol in the fish quality evaluation and storage time estimation.

Method:
Eight gutted yellowfin tuna of 20, 30, and 40 kg up were used in the study. Five panelists
participated in the QIM development, training and application. Control and/or validation
analyses were sensory assessment by a control sheet, total volatile basic nitrogen (TVB-N)
quantification, and total viable count (TVC) determination. Chilled storage of tuna was performed
in liquid ice and traditional crushed block ice. Partial least square regression (PLS-R)
was conducted on quality index (QI) dataset over storage time to find the regression line and
prediction accuracy.

Results:
The established QIM protocol for gutted yellowfin tuna comprised 6 attributes (namely,
color of whole fish, odor of whole fish and flesh, eyes, appearance of whole fish, flesh color
and flesh texture) and a maximal QI of 15. The PLS-R showed that QI could be used to estimate
the remaining time with a precision of ± 2.0 and 1.4 days for fish stored in slurry ice and
crushed ice, respectively. The TVB-N content in the fish flesh maintained below the acceptable
level of 25 mg N/100 g throughout the storage period, which made the parameter impractical to
detect the fish shelf life. The TVC overreached the allowable level of 107 CFU/g around the
time of fish rejection by the sensory method.

Conclusion:
The developed QIM scheme for yellowfin tuna showed to be more advantageous
in detecting fish quality changes compared to the control sensory method and could be used to
estimate the fish's remaining shelf life.
BAPST. A Combo of Common Use Drugs as Metabolic Therapy for
Cancer: A Theoretical Proposal
Authors: Romo-Perez Adriana , Dominguez-Gomez Guadalupe , Chavez-Blanco Alma , Taja-Chayeb Lucia , Gonzalez-Fierro Aurora , Garcia-Martinez Elisa , Correa-Basurto Jose , Duenas-Gonzalez Alfonso 
Published: October 2021

:
Cancer therapy advances have yet to impact global cancer mortality. One of the factors
limiting mortality burden reduction is the high cost of cancer drugs. Cancer drug repurposing has already
failed to meet expectations in terms of drug affordability. The three FDA-approved cancer
drugs developed under repurposing: all-trans-retinoic acid, arsenic trioxide, and thalidomide do not
differ in price from other drugs developed under the classical model. Though additional factors affect
the whole process from inception to commercialization, the repurposing of widely used, commercially
available, and cheap drugs may help. This work reviews the concept of the malignant
metabolic phenotype and its exploitation by simultaneously blocking key metabolic processes altered
in cancer. We elaborate on a combination called BAPST, which stands for the following
drugs and pathways they inhibit: Benserazide (glycolysis), Apomorphine (glutaminolysis), Pantoprazole
(Fatty-acid synthesis), Simvastatin (mevalonate pathway), and Trimetazidine (Fatty-acid
oxidation). Their respective primary indications are:
• Parkinson's disease (benserazide and apomorphine).
• Peptic ulcer disease (pantoprazole).
• Hypercholesterolemia (simvastatin).
• Ischemic heart disease (trimetazidine).
When used for their primary indication, the literature review on each of these drugs shows that
they have a good safety profile and lack predicted pharmacokinetic interaction among them. Based
on that, we propose that the BAPST regimen merits preclinical testing.
Green and Sustainable Technology: Efficient Strategy for the Synthesis of
Biologically Active Pyrimidine Derivatives
Authors: Sahoo Biswa Mohan , Kumar B.V.V Ravi , Panda Krishna Chandra , Sruti Jammula , Tiwari Abhishek , Patra Srimanta 
Published: October 2021

:
Green chemistry is also referred to as sustainable technology, which involves the design,
synthesis, processing and the use of chemical substances by reducing or eliminating the chemical
hazards. This strategy focuses on atom economy, use of safer solvents or chemicals, use of raw materials
from renewable resources, consumption of energy and decomposition of the chemical substances
to non-toxic material which are eco-friendly. So, this technology is utilized for the sustainable
development of novel heterocyclic scaffold like pyrimidine derivatives. Pyrimidine is a six
membered heterocyclic aromatic compound with two nitrogen atoms at positions 1 and 3 in the
ring system. Among the other heterocyclic compounds, pyrimidine derivatives play a major role
due to their diverse promising biological activities, such as antimicrobial, antifungal, anti-viral, anti-
tubercular, anti-diabetic, anti-hypertensive, anticancer, anthelmintic, antioxidant, anti-epileptic,
antipsychotic, anti-anxiety, antimalarial, antihistaminic, anti-parkinsonian, analgesic and anti-inflammatory
etc. The various green methods used for the synthesis of pyrimidine derivatives include
microwave assisted synthesis, ultrasound induced synthesis, ball milling technique, grinding
technique and photo-catalysis. These processes enhance the rate of the reaction that leads to high selectivity
with improved product yields as compared to the conventional synthetic methods. This review
is focused on the green synthesis of biologically active pyrimidine derivatives.
An Evidence-Based Review of Medicinal Plants in the Overall Management of Chronic Fatigue
Authors: Tyagi Sakshi , Shekhar Nikhila , Thakur Ajit Kumar 
Published: October 2021

Background:
Fatigue is generally a normal response to physical exertion
or any stressful situation. Its prevalence rates have reached the level of
1.5-3% among the general population. Due to the unclear etiology, diagnostic ambiguity,
and resultant heterogeneousness among the population, there is a lack of
a solid treatment regimen for fatigue. As the absolute treatment option is vague,
patients are moving towards complementary and alternative medicines. Hence it
is mandatory to review the efficiency of complementary and alternative therapies
along with herbal medicines.

Objective:
The purpose of this review is to carry out an evidence-based exploration
of the potentiality of medicinal plants in the treatment and management of fatigue.

Methods:
This evidence-based review was performed by conducting a literature
review of the available studies from the PubMed database.

Results:
The study was based on 23 pre-clinical and clinical studies. It showed
that medicinal herbs including Andrographis paniculata, Angelina sinensis, Astralagus
membranaceus, Cordyceps sinensis, Panax ginseng, Gymnostemma pentaphyllum,
Holy Basil, Lepidium meyenii, Rhodiola rosea, and Withania somnifera
that belong to various traditional medicinal systems such as Ayurveda and
Chinese Traditional Medicines can be a promising strategy to manage the various
forms of fatigue.

Conclusion:
On the basis of these studies, it was concluded that the medicinal
herbs and the phytochemicals within have a possible role in improving the symptoms
associated with fatigue which can be further validated to produce targeted
therapy for fatigue.
Electronic Properties and Pseudo-Electromagnetic Fields of Highly Conjugated Carbon Nanostructures
Authors: Bracamonte Angel Guillermo , Hutchinson William 
Published: October 2021

:In this communication, we discuss the particular electronic and quantum properties from graphene and carbon allotropes to highly conjugated carbon chemical structures from recent research. Moreover, the chemical modifications of these types of materials were analyzed against the concept of their inert properties, thus identifying that their surfaces could be modified to incorporate different properties, functionalities, and couple electronic effects, among others. Their versatility has been shown based on simple chemical reactions in controlled and targeted conditions of synthesis. Variable designs could be tuned from proof of concepts to functional materials for targeted applications. In addition, a proof of concept was discussed for Electron Transfer (ET) applications to show their electronic properties. Finally, the use of highly conjugated chemical structures to higher hierarchical ordered carbon structures, carbon nanotubes, graphene and carbon allotropes in electron and opto-responsive metamaterials, has been analyzed. Thus, new insights into multi-modal characteristics of materials have been discussed.
Advances in New Matter Properties and Applications of Hybrid Graphene-
Based Metamaterials
Authors: Bracamonte Angel Guillermo 
Published: October 2021

:
Graphene as an organic material has attracted special attention due to its electronic
and conductive properties. Moreover, its highly conjugated chemical structures and relatively
easy modification have allowed varied design and control of targeted properties and applications.
In addition, this nanomaterial with pseudo-electromagnetic fields has led to the emergence
of photonics, electronics and quantum interactions with their surroundings, generating new
properties of materials. This short review aims at discussing many of these studies of new materials
based on graphene for light and electronic interactions, conductions and new modes of nonclassical
light generation. These new materials and metamaterials are being developed. For this
reason, some representative examples from research with potential applications have been
shown and discussed, in addition to their incorporation in real advanced devices and miniaturized
instrumentation. Accordingly, this special issue entitled “Design and Synthesis of Hybrid
Graphene-based Metamaterials” is intended to review the state-of-the-art in this multidisciplinary
field.
Electronic Records With Tablets at the Point of Care in an Internal Medicine Unit: Before-After Time Motion Study
Authors: Pérez-Martí Montserrat , Casadó-Marín Lina , Guillén-Villar Abraham 
Published: October 2021

Background
There are many benefits of nursing professionals being able to consult electronic health records (EHRs) at the point of care. It promotes quality and patient security, communication, continuity of care, and time dedicated to records.

Objective
The aim of this study was to evaluate whether making EHRs available at the point of care with tablets reduces nurses’ time spent on records compared with the current system. The analysis included sociodemographic and qualitative variables, time spent per patient, and work shift. This time difference can be used for direct patient care.

Methods
A before-after time motion study was carried out in the internal medicine unit. There was a total of 130 observations of 2 hours to 3 hours in duration of complete patient records that were carried out at the beginning of the nurses' work shifts. We calculated the time dedicated to measuring vital signs, patient evaluation, and EHR recording. The main variable was time spent per patient.

Results
The average time spent per patient (total time/patients admitted) was lower with the tablet group (mean 4.22, SD 0.14 minutes) than with the control group (mean 4.66, SD 0.12 minutes); there were statistically significant differences (W=3.20, P=.001) and a low effect (d=.44) between groups. The tablet group saved an average of 0.44 (SD 0.13) minutes per patient. Similar results were obtained for the afternoon shift, which saved an average of 0.60 (SD 0.15) minutes per patient (t34=3.82, P=.01) and high effect (d=.77). However, although there was a mean difference of 0.26 (SD 0.22) minutes per patient for the night shift, this was not statistically significant (t29=1.16, P=.25). The “nonparticipating” average age was higher (49.57, SD 2.92 years) compared with the “afternoon shift participants” and “night shift participants” (P=.007). “Nonparticipants” of the night shift had a worse perception of the project.

Conclusions
This investigation determined that, with EHRs at the point of care, the time spent for registration by the nursing staff decreases, because of reduced movements and avoiding data transcription. It eliminates unnecessary work that does not add value, and therefore, care is improved. So, we think EHRs at the point of care should be the future or natural method for nursing to undertake. However, variables that could have a negative effect include age, night shift, and nurses’ perceptions. Therefore, it is proposed that training in the different work platforms and the participation of nurses are fundamental axes that any institution should consider before their implementation.
An App-Based Just-in-Time Adaptive Self-management Intervention for Care Partners (CareQOL): Protocol for a Pilot Trial
Authors: Carlozzi Noelle E , Choi Sung Won , Wu Zhenke , Miner Jennifer A , Lyden Angela K , Graves Christopher , Wang Jitao , Sen Srijan 
Published: October 2021

Background
Care partners (ie, informal family caregivers) of individuals with health problems face considerable physical and emotional stress, often with a substantial negative impact on the health-related quality of life (HRQOL) of both care partners and care recipients. Given that these individuals are often overwhelmed by their caregiving responsibilities, low-burden self-management interventions are needed to support care partners to ensure better patient outcomes.

Objective
The primary objective of this study is to describe an intensive data collection protocol that involves the delivery of a personalized just-in-time adaptive intervention that incorporates passive mobile sensor data feedback (sleep and activity data from a Fitbit [Fitbit LLC]) and real time self-reporting of HRQOL via a study-specific app called CareQOL (University of Michigan) to provide personalized feedback via app alerts.

Methods
Participants from 3 diverse care partner groups will be enrolled (care partners of persons with spinal cord injury, care partners of persons with Huntington disease, and care partners of persons with hematopoietic cell transplantation). Participants will be randomized to either a control group, where they will wear the Fitbit and provide daily reports of HRQOL over a 3-month (ie, 90 days) period (without personalized feedback), or the just-in-time adaptive intervention group, where they will wear the Fitbit, provide daily reports of HRQOL, and receive personalized push notifications for 3 months. At the end of the study, participants will complete a feasibility and acceptability questionnaire, and metrics regarding adherence and attrition will be calculated.

Results
This trial opened for recruitment in November 2020. Data collection was completed in June 2021, and the primary results are expected to be published in 2022.

Conclusions
This trial will determine the feasibility and acceptability of an intensive app-based intervention in 3 distinct care partner groups: care partners for persons with a chronic condition that was caused by a traumatic event (ie, spinal cord injury); care partners for persons with a progressive, fatal neurodegenerative disease (ie, Huntington disease); and care partners for persons with episodic cancer conditions that require intense, prolonged inpatient and outpatient treatment (persons with hematopoietic cell transplantation).

Trial Registration
ClinicalTrials.gov NCT04556591; https://clinicaltrials.gov/ct2/show/NCT04556591

International Registered Report Identifier (IRRID)
DERR1-10.2196/32842
Astaxanthin-Producing Microalgae Identification Using 18S rRNA : Isolates from Bangkalan Mangrove Waters and Sowan Tuban Northern Waters, East Java, Indonesia
Authors: Ermavitalini Dini , Rukhmana Siska Yulia , Meidina Thalita , Baskoro Leonardo Pascalis Dimas Cahyo , Saputro Triono Bagus , Ni’matuzahroh Ni’matuzahroh , Purnobasuki Hery 
Published: October 2021

Microalgae are a group of micro-sized photosynthetic organisms that range from prokaryotic cyanobacteria to eukaryotic algae. Microalgae are widely used as a source of natural food, cosmetic ingredients, food ingredients, and a source of pigments. This study aims to identify species of four microalgae isolates named B1, B2, B3, and S2 from Bangkalan Mangrove Waters and Sowan Tuban Northern Waters, and to determine their astaxanthin pigment concentration under 1 M NaCl. Species identification was carried out through a molecular approach by utilization of an 18S rRNA gene marker. A quantitative test of astaxanthin concentration was carried out by spectrophotometric analysis. Molecular identification results show that isolates B1 and B3 are closely related to Chlorella sp., while isolates B2 and S2 are closely related to Picochlorum maculatum. Moreover, under salinity stress condition of 1 M NaCl shown a significant decrement of astaxanthin production compared to the control treatment. At 1 M NaCl, the astaxanthin content of isolate B1 was 4x10-5 mgL-1, isolate B2 was 2x10-5 mgL-1, isolate B3 was 1x10-5 mgL-1, and isolate S2 was 6x10-6 mgL-1. All in all, isolate S2 has the highest astaxanthin among the other isolates at normal conditions, while under salt stress regime, isolate B1 shown to be the best source for astaxanthin.