bluuebunny/crossref_metadata_2025_split huggingface dataset:
ACL Injuries and Meniscal Lesion: Hand in Hand?
Authors: Nivetha U. , Vignesh . , Anvesh . , Munis . , Balasubramaniam Navin 
Published: December 2021

Objective: To assess the incidence, nature and pattern of meniscal tear in ACL injury. Methodology: A retrospective study was conducted among the patients who were admitted and treated for ACL tear in Saveetha Medical And College And Hospital over a 2-year period from August 2019-August 2021. There were 52 patients admitted and treated for the same. The case records of each of the patients were reviewed to find the incidence of meniscal lesion in ACL tear and were then analyzed using appropriate statistical tests.
Results: 52 patients with ACL tear were reviewed in this study. ACL tear was most commonly reported in younger age group of 20-29 (46.15%). Out of which, 19(36.54%) patients had meniscal tears. About 9(47.37%) patients had lateral meniscus tear, 6(31.58%) had medial meniscus tear and 4(21.05%) had bilateral meniscal tear. It was seen that bucket handle injury (n=12) was the most common meniscus tear overall. Radial tear was most specifically common in bilateral meniscus injury (N=4).
Conclusion: Meniscal tears are the most common intra articular lesions associated with ACL tear. It was most commonly reported in the age group of 20-29. We found that the incidence of lateral meniscal tear was significantly higher in the patients rather than medial meniscal tear. Bucket handle injury was the most commonly reported tear in meniscal injury. Therefore, the surgeon needs to equip himself with the necessary meniscal repair instruments in his armamentarium
An In vitro Evaluation of Antidiabetic Activity of Alpinia galangal and Alpinia calcarata
Authors: Revathi V. Miss , Anuradha G. , Sumathy S. 
Published: December 2021

Background: The herbs, genus Alpinia calcarata and Alpinia galanga that underneath the family Zingiberaceae are rhizomatous and extremely aromatic. The study is to investigate the anti-diabetic activity of Alpinia galanga and Alpinia calcarata in-vitro.
Material and Methods: The inhibitory effect of Alpinia galanga and Alpinia calcarata on α-amylase and α-glucosidase activities were evaluated.
Results: The results revealed that both Alpinia galanga and Alpinia calcarata inhibited α-amylase and α-glucosidase activities in a dose-dependent manner (200–1000 μg/mL). However, Alpinia calcarata possess better antidiabetic activity than Alpinia galangal.
Conclusion: The presence of phenolic and other phytochemical content in the herbs might be the reason for their ability to inhibit α-amylase and α-glucosidase activities. Thus, the drug formulating from the herbs, Alpinia galanga and Alpinia calcarata could be part of the potential alternative for synthetic anti-diabetic drug.
Cytotoxic Effect of Hydroethanolic Extract of Citrullus colocynth (L) Fruit against Human Lung Cancer Cell Line
Authors: Sowmya K. P. , S Preetha , Selvaraj J. , Prathap Lavanya 
Published: December 2021

Citrullus colocynthis is a traditional medicinal plant that belongs to the cucurbitaceae family. The extract of the fruit is rich in therapeutic phytochemicals. Lung cancer is a disease with high mortality and morbidity rates. Recently the research has been focused on herbal medicine as a treatment approach for cancer because of its no or less side effects. The aim of the study is to know about the anticancer effect of hydroethanolic extract of Citrullus colocynthis fruit against human lung cancer cell line through apoptosis pathway. Cell viability test was done by MTT assay. The mRNA expression of Bcl2 and Bcl-xL was done using the real-time PCR. The obtained data was analysed statistically by one way analysis of variance and Duncan multiple range test with graph prism version 5 to analyse the significance. The significance was considered at p<0.05 level in Duncan’s test. Citrullus colocynthis fruit extract increased the inhibition of growth of lung cancer cells. The activity of Bcl2 and Bcl xL was significantly down regulated at 400μg. The study concludes that Citrullus colocynthis fruit extract has anticancer activity on A549 human lung cancer cell line through apoptosis pathway.
A case report on Severe Acute Respiratory Infection
Authors: Bawane Shiva , Mahakalkar Manjusha , Ankar Ruchira 
Published: December 2021

Introduction: Severe Acute Respiratory Syndrome is a zootoxic viral respiratory illness caused by the severe acute respiratory syndrome corona virus (SARS-CoV or SARS-The syndrome was the cause of the Severe Acute Respiratory Syndrome outbreak in 2002–2004. The virus was traced back to cave-dwelling horseshoe bats via Asian palm civets in late 2017 by Chinese scientists in Xizang Yi Ethnic Township, Yunnan. SARS was a rare illness; there were 8,422 cases at the end of the pandemic in June 2003, with an 11 percent case fatality rate (CFR) (CoV-1), the initial strain of the SARS corona virus species (SARSr-CoV).
Clinical Finding: Swelling over Right. Half of face, Breathlessness.
Diagnostic Evaluation: Blood test: Hb – 9.2gm%, Total RBC count- 3.22 millions/cu.mm, HCT- 26.6%, Total WBC count – 6600/cu.mm, Monocytes-02%, granulocytes-85%, lymphocytes-10000 /mcl. HRCT Scan OF Thorax: Multiple ill defined patchy ground glass opacities with consolidation and sepal thickening in bilateral lungs filled s/o infective etiology possibility of atypical viral pneumonia. View of covid positive PCR test; imagine grading corad-6 with CT severity score – 03\25 (Mild).
Therapeutic Intervention: Inj.Amphotericin-B 500mg IV, Inj.Piptaz 4.4gm IV x TDS, Inj.levoflox 500 mg x OD, Inj.Clindamycin 300mg x BD, Inj.pantaprazol 40 mg x OD, Inj.Emset 4mg x TDS, Tab. limcee 500 mg x BD.
Outcome: After Treatment, the patient shows improvement. His swelling over face decrease, and breathlessness decrease.
Conclusion: My patient was admitted in SARI-HDU, AVBRH with complaint of swelling over face Right side, and breathlessness. After getting appropriate treatment his condition was improved.
Comparison of Random Blood Sugar and pH of Blood- A Clinicopathological Study
Authors: Antony P. Titus Lalith , Sinduja Palati , Priyadharshini R. 
Published: December 2021

Aim: This study aims to compare the random blood sugar pH of the blood.
Introduction: Hyperglycemia is a risk factor for the impairment of periodontal health while periodontal disease, in turn, is responsible for the adverse effects on glycemic control and the pathophysiology of diabetes-related complications. An increase in blood sugar levels has a direct effect on pH with respect to age. Hence this study deals with the association of random blood sugar levels and pH with age, gender, and dental complaints.
Materials and Methods: 20 random blood samples were collected from the patients in Saveetha Dental College. The random blood sugar level was analyzed by the semi-quantitative method and the pH was analyzed by using a multi reagent strip. And the results were statistically analyzed using SPSS software and represented as pie charts and bar graphs.
Results and Discussion: The overall mean value of RBS and blood pH was found to be 138.4 mg/dl and 7.06 respectively. The mean RBS value is higher in the 41-50 years age group of people than in other age categories and the mean pH value is same for all age categories. In the present study, samples with periodontic complaints have higher mean value of RBS values (193) than other dental complaints and the mean pH value is same for all dental complaints.
Conclusion: Within the limits of the study, it can be observed that there is a significant association between the age group, gender, and dental complaints with RBS and pH of the patients. However, further studies must be conducted to have more accurate results and elicit the association between pH and RBS with age and gender.
Use of Chlorhexidine on Umbilicus in Prevention of Neonatal Sepsis
Authors: Mohsin Rimsha , Khan Palwasha , Naveed Maryum 
Published: December 2021

Objectives: The main objective of the study is to analyse the use of chlorhexidine on umbilicus in prevention of neonatal sepsis.
Materials and Methods: This cross sectional study was conducted in Sheikh Zaid hospital Rahim Yaar Khan during March 2020 till September 2020. The data was collected through non-probability consecutive sampling technique. The data was collected from 100 infants. Arrangements with a grouping of 4.0% free chlorhexidine were set up by weakening 20% chlorhexidine digluconate to the proper fixation with cleaned water.
Results: The data was collected from 100 neonates. All the demographic values which include age, gender, gestational age and mode of delivery were calculated. According to baseline values the birth weight of chlorhexidine group was 1.87 ± 0.463 kg and dry cord group was 1.69 ± 0.421 kg. Umbilical sepsis is observed in only 1 patient in group I and in 3 patients in group II. Only single mortality was observed in group I and in 6 neonates in group II.
Conclusion: It is concluded that chlorhexidine umbilical cord care is more appropriate than the currently WHO recommended dry cord care.
Overview on Diagnosis and Management of Polymyositis
Authors: Hussein Mohammed Salah , Almandeil Atyaf Khalid , Alsulami Sarah Shujaa , Alwayli Amaal Abdulrahman , Alwayli Amal Abdulrahman , Mubarak Ataa Salem , AlEnazi Nawaf Talal , Alrashidi Abdulaziz Mansour H. , Alomran Sarh abdulhameed , Haddad Habeeb Abdullah Al , Alshehri Turki Mohammed 
Published: December 2021

Polymyositis (PM) is an autoimmune disorder; result from abnormal activation of cytotoxic T lymphocytes (CD8 cells) and macrophages against muscular antigens as well as the strong extrafusal muscular expression of major histocompatibility complex class 1 causing damage to the endomysium of the skeletal muscles. Polymyositis develops over the months as compared to inclusion body myositis (IBM), which is a slowly progressive chronic myopathy developing in older individuals over a period of months to years with more severe symptoms. Many patients require treatment for many years. Polymyositis affects the distal musculature of the esophagus in the late stage of disease in up to 70% of the patients leading to the inability to swallow, as well as regurgitation problems that can cause aspiration pneumonia. The principal goals of therapy are to improve strength and improve physical functioning. Many patients require treatment for several years. The 5-year survival rate for treated patients is in the order of 95%. Up to one-third of PM patients may be left with some degree of residual muscle weakness.
The awareness of Cervical Cancer Screening among Appalachian Women: Review Article
Authors: Algaows Faisal Suliman , Jazzar Yara Saeed , Almalki Mohammed Hassan , Almeqbel Shahad Bandar , Almughazzawi Raghad Abdulrahman , Aljaber Maitham Jaber Abdullah , Mousali Reem Yahya , Alharbi Mohammed Falah , Alshahrani Abdullah Mohammed , Alkhonain Issa Mohammad , Alharbi Fahad Obaidallah B. 
Published: December 2021

There is a long tradition of negative experiences with cancer among Appalachian women that manifests as avoidance behaviors in seeking screening and follow up because of fear of a cancer diagnosis. The avoidance is usually seen as ‘passive refusal,’ but also occurs in an active form as refusal to obtain services even when offered. This problem is compounded by poverty, which influences many parts of life and is associated with lack of transportation, child care, and exclusive reliance on public health departments and other safety net health care providers to seek cancer screening. Pap tests have reduced the annual incidence cervical cancers.
The study aims to overview cervical cancer methods and recommendations among women in reproductive age.
A Case Report on Acute Transient’s Psychotic Disorders
Authors: Wawre Sonali , Dhengare Archana , Wagh Pranali , Bikade Kanchan , Raut Aarti , Gujar Samruddhi 
Published: December 2021

Background: Little is known about acute and transient psychotic disorders (ATPD), a diagnostic category introduced with ICD-10.
Case Presentation: Acute transient psychotic disorder is a heterogeneous group of disorders characterised by the acute onset of psychotic symptoms such as delusion, hallucination and perceptual disturbances, and by the severe disruption of ordinary behaviour. Patient history: The Male patient 48 year old who was apparently admitted in AVBRH on date 08/05/2021 with chief complaint was Abnormal behaviour( taking clothes off in public ), irritability, aggressive, muttering and smiling to self from 10 days back. His parents once locked him in a room as they fear he might hurt him. He was taken to a faith healer in Pandarkawda twice by his parents. The Baba gave him some mysterious beats like bracelet to wear which eventually decreased his symptoms for 3 days but the symptoms persisted from the fourth day. This time, the Baba mixed a lemon juice, turmeric powder & kumkuma (a powder made from dried turmeric with a bit of slaked lime) and applied all over him eyes which severely inflamed & burnt his eyes. His eye injury elevated his psychotic symptoms which is why his parents took him to psychiatric OPD in AVBRH.
Past History: Patient was apparently asymptomatic 2 yrs back. He was married to a woman of his parent’s choice. His marriage life was stressful and unhealthy. He was underestimated by his wife due to his low qualification and health problem.
Clinical Finding: The patient has been undergone with various investigations like culture, blood tests, Physical examination and mental status examination symptomatically with antipsychotic agent and anticonvulsant such as Tab Olanzapine 10mg- HS, Tab Clonazepam 0.5mg – SOS.
Medical Management: Antibiotic eye drop homatropine and eye ointment ciprofloxacin.
Nursing Management: Administered fluid replacement i.e DNS and RL, eye care was done with betadine and Normal Saline solutions, eye care by administering eye drops and monitored all vital signs hourly.
Conclusion: Patient was admitted to hospital with the chief complaint of muttering to self, irritability and eye injury, blisters, pus discharge from eyes and his condition was very critical and patient was admitted in AVBR Hospital ,immediate treatment was started by health team member and all possible treatment were given and now the patient condition is satisfactory.
Evolutionary Sequence of Spacetime and Intrinsic Spacetime and Associated Sequence of Geometries in Metric Force Fields I
Authors: Joseph O. Akindele Adekugbe 
Published: December 2021

Two classes of three-dimensional metric spaces are identified. They are the conventional three-dimensional metric space and a new ‘three-dimensional’ absolute intrinsic metric space. Whereas an initial flat conventional proper metric space IE′3 can transform into a curved three-dimensionalRiemannian metric space IM′3 without any of its dimension spanning the time dimension (or in the absence of the time dimension), in conventional Riemann geometry, an initial flat ‘three-dimensional’ absolute intrinsic metric space ∅IˆE3 (as a flat hyper-surface) along the horizontal, evolves into a curved ‘three-dimensional’ absolute intrinsic metric space ∅IˆM3, which is curved (as a curved hyper-surface) toward the absolute intrinsic metric time ‘dimension’ along the vertical, and it is identified as ‘three-dimensional’ absolute intrinsic Riemannian metric space. It invariantly projects a flat ‘three-dimensional’ absolute proper intrinsic metric space ∅IE′3ab along the horizontal, which is made manifested outwardly in flat ‘three-dimensional’ absolute proper metric space IE′3ab, overlying it, both as flat hyper-surfaces along the horizontal. The flat conventional three-dimensional relative proper metric space IE′3 and its underlying flat three-dimensional relative proper intrinsic metric space ∅IE′3 remain unchanged. The observers are located in IE′3. The projective ∅IE′3ab is imperceptibly embedded in ∅IE′3 and IE′3ab in IE′3. The corresponding absolute intrinsic metric time ‘dimension’ is not curved from its vertical position simultaneously with ‘three-dimensional’ absolute intrinsic metric space. The development of absolute intrinsic Riemannian geometry is commenced and the conclusion that the resulting geometry is more all-encompassing then the conventional Riemannian geometry on curved conventional metric space IM′3 only is reached.
Supramolecular Reinforcement of Polymer–Nanoparticle Hydrogels for Modular Materials Design
Authors: Bovone Giovanni , Guzzi Elia A. , Bernhard Stéphane , Weber Tim , Dranseikiene Dalia , Tibbitt Mark W. 
Published: December 2021

AbstractMoldable hydrogels are increasingly used as injectable or extrudable materials in biomedical and industrial applications owing to their ability to flow under applied stress (shear‐thin) and reform a stable network (self‐heal). Nanoscale components can be added to dynamic polymer networks to modify their mechanical properties and broaden the scope of applications. Viscoelastic polymer–nanoparticle (PNP) hydrogels comprise a versatile and tunable class of dynamic nanocomposite materials that form via reversible interactions between polymer chains and nanoparticles. However, PNP hydrogel formation is restricted to specific interactions between select polymers and nanoparticles, resulting in a limited range of mechanical properties and constraining their utility. Here, a facile strategy to reinforce PNP hydrogels through the simple addition of α‐cyclodextrin (αCD) to the formulation is introduced. The formation of polypseudorotoxanes between αCD and the hydrogel components resulted in a drastic enhancement of the mechanical properties. Furthermore, supramolecular reinforcement of CD–PNP hydrogels enabled decoupling of the mechanical properties and material functionality. This allows for modular exchange of structural components from a library of functional polymers and nanoparticles. αCD supramolecular binding motifs are leveraged to form CD–PNP hydrogels with biopolymers for high‐fidelity 3D (bio)printing and drug delivery as well as with inorganic NPs to engineer magnetic or conductive materials.
Cross‐age peer mentoring for youth: A meta‐analysis
Authors: Burton Samantha , Raposa Elizabeth B. , Poon Cyanea Y. S. , Stams Geert Jan J. M. , Rhodes Jean 
Published: December 2021

AbstractAlthough most mentoring programs for youth are structured around intergenerational relationships, a growing number of programs rely on cross‐age peer mentoring. Such programs capitalize on the availability of youth mentors to promote positive outcomes in younger peers. This study used a multilevel meta‐analytic approach to estimate the effect size of cross‐age peer mentoring programs and evaluate potential moderators of peer mentoring program effectiveness. Analyses included six studies and revealed a medium‐sized overall effect of cross‐age peer mentoring programs (g = 0.45). Several characteristics moderated effect sizes, with larger effects for programs that were conducted outside of the school setting (i.e., weekend, summer, or in community settings), conducted in urban settings, and had moderate/high levels of adult oversight and supervision. Results highlight the potential benefits of cross‐age peer mentoring for youth.
Exciting progress in the transition metal‐catalyzed synthesis of oxepines, benzoxepines, dibenzoxepines, and other derivatives
Authors: Rafiee Fatemeh , Hasani Samira 
Published: December 2021

AbstractFrom the past decade so far, the synthesis of seven‐membered oxacycles especially natural monocyclic oxepines and their annulated derivatives has received considerable attention. Due to the importance of these valuable scaffolds in natural products, pharmaceuticals, and prospective drugs, as well as their strong potential for use in the biosynthesis and metabolism of monocyclic and polycyclic aromatic compounds, a variety of synthesis strategies have been proposed to afford oxepine moiety. Among the versatile and attractive approaches, this review article focuses on the exciting developments in transition metal‐mediated reactions as the key step in the synthesis of oxepine derivatives from 2010 to early 2021.
Different kelp species support unique macroinvertebrate assemblages, suggesting the potential community‐wide impacts of kelp harvesting along the Humboldt Current System
Authors: Carbajal Patricia , Gamarra Salazar Alex , Moore Pippa J. , Pérez‐Matus Alejandro 
Published: December 2021

Abstract

Kelp forests provide habitat for myriad species yet remain poorly studied in some ecoregions, including where there is increasing interest in commercial kelp harvesting for the lucrative alginate industry.
To identify indicators for monitoring the impacts of kelp harvesting, the structure and composition of macrobenthic invertebrate assemblages associated with large brown macroalgae, Eisenia cokeri, Lessonia trabeculata and Macrocystis pyrifera, from the Humboldt Current System of Peru were determined.
Within kelp habitats two distinct habitats were sampled: (a) adult kelp holdfasts; and (b) the benthos adjacent to the kelp sporophyte (hereafter under‐canopy rock). For each sample, organisms were identified, enumerated and weighed.
Totals of 108, 102 and 113 different species were found associated with Eisenia cokeri, M. pyrifera and L. trabeculata, respectively comprising distinct assemblages associated with each kelp forest. Both habitat types (holdfasts and under‐canopy rock) supported diverse, but different, macroinvertebrate assemblages, with richness, abundance and functional trophic groups in general higher in holdfasts compared with on under‐canopy rock. Lastly, macroinvertebrate abundance, biomass, and species richness significantly increased with holdfast size.
Results confirm that each kelp species is unique in terms of associated assemblage composition and indicate that kelp harvesting for the alginate industry may have large impacts. We suggest that these effects on associated biodiversity should be incorporated within kelp harvesting management plans.
We suggest that holdfast diameter is a good ecological indicator as reductions in holdfast size across the population will indicate a decline in the diversity of macroinvertebrates that are important food sources for higher order organisms. We therefore suggest that monitoring studies include morphological measurements as well as measurement of kelp density.