bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plenty of big projections imply big pieces of Lipschitz graphs
Authors: Orponen Tuomas 
Published: June 2021

AbstractI prove that closed n-regular sets $$E \subset {\mathbb {R}}^{d}$$

E
⊂

R

d

with plenty of big projections have big pieces of Lipschitz graphs. In particular, these sets are uniformly n-rectifiable. This answers a question of David and Semmes from 1993.
Midtrophic fish feeding modes at the poles: an ecomorphological comparison of polar cod (Boreogadus saida) and Antarctic silverfish (Pleuragramma antarctica)
Authors: Carlig Erica , Christiansen Jørgen S. , Di Blasi Davide , Ferrando Sara , Pisano Eva , Vacchi Marino , O’Driscoll Richard L. , Ghigliotti Laura 
Published: June 2021

AbstractThe polar cod (Boreogadus saida) and the Antarctic silverfish (Pleuragramma antarctica) are pelagic fish endemic to the Arctic and Antarctica sea, respectively. Both species are abundant and play a central role as midtrophic wasp-waist species in polar ecosystems. Due to their biological and ecological characteristics (small size, complex life histories, relatively short generation cycles, movement capability, planktivorous diet, and importance as prey), the polar cod and the Antarctic silverfish are potentially good sentinels of ecosystem change. Changes in polar zooplankton communities are well documented. How changes impact ecosystems as a whole largely depend on the degree of diet specialization and feeding flexibility of midtrophic species. Here, we provide the ecomorphological characterization of polar cod and Antarctic silverfish feeding performances. A comparative functional ecology approach, based on the analysis of morpho-anatomical traits, including calculation of suction index and mechanical advantage in jaw closing, was applied to profile the feeding modes and flexibility of the two species. Ecomorphological evidence supports differences in food acquisition: the polar cod appears able to alternate particulate ram-suction feeding to a pump filter feeding, and the Antarctic silverfish results be both a particulate ram and a tow-net filter feeder. Both species exhibit opportunistic feeding strategies and appear able to switch feeding mode according to the abundance and size of the available prey, which is a clue of potential resilience to a changing environment.
High spatial resolution photo mosaicking for the monitoring of coralligenous reefs
Authors: Casoli E. , Ventura D. , Mancini G. , Pace D. S. , Belluscio A. , Ardizzone G. 
Published: June 2021

AbstractCoralligenous reefs are characterized by large bathymetric and spatial distribution, as well as heterogeneity; in shallow environments, they develop mainly on vertical and sub-vertical rocky walls. Mainly diver-based techniques are carried out to gain detailed information on such habitats. Here, we propose a non-destructive and multi-purpose photo mosaicking method to study and monitor coralligenous reefs developing on vertical walls. High-pixel resolution images using three different commercial cameras were acquired on a 10 m2 reef, to compare the effectiveness of photomosaic method to the traditional photoquadrats technique in quantifying the coralligenous assemblage. Results showed very high spatial resolution and accuracy among the photomosaic acquired with different cameras and no significant differences with photoquadrats in assessing the assemblage composition. Despite the large difference in costs of each recording apparatus, little differences emerged from the assemblage characterization: through the analysis of the three photomosaics twelve taxa/morphological categories covered 97–99% of the sampled surface. Photo mosaicking represents a low-cost method that minimizes the time spent underwater by divers and capable of providing new opportunities for further studies on shallow coralligenous reefs.
Nanopore creation in MoS2 and graphene monolayers by nanoparticles impact: a reactive molecular dynamics study
Authors: Noori Hamidreza , Mortazavi Bohayra , Keshtkari Leila , Zhuang Xiaoying , Rabczuk Timon 
Published: June 2021

AbstractIn this work, extensive reactive molecular dynamics simulations are conducted to analyze the nanopore creation by nanoparticles impact over single-layer molybdenum disulfide (MoS2) with 1T and 2H phases. We also compare the results with graphene monolayer. In our simulations, nanosheets are exposed to a spherical rigid carbon projectile with high initial velocities ranging from 2 to 23 km/s. Results for three different structures are compared to examine the most critical factors in the perforation and resistance force during the impact. To analyze the perforation and impact resistance, kinetic energy and displacement time history of the projectile as well as perforation resistance force of the projectile are investigated. Interestingly, although the elasticity module and tensile strength of the graphene are by almost five times higher than those of MoS2, the results demonstrate that 1T and 2H-MoS2 phases are more resistive to the impact loading and perforation than graphene. For the MoS2nanosheets, we realize that the 2H phase is more resistant to impact loading than the 1T counterpart. Our reactive molecular dynamics results highlight that in addition to the strength and toughness, atomic structure is another crucial factor that can contribute substantially to impact resistance of 2D materials. The obtained results can be useful to guide the experimental setups for the nanopore creation in MoS2or other 2D lattices.
The ACURATE neo2 valve system for transcatheter aortic valve implantation: 30-day and 1-year outcomes
Authors: Möllmann Helge , Holzhey David M. , Hilker Michael , Toggweiler Stefan , Schäfer Ulrich , Treede Hendrik , Joner Michael , Søndergaard Lars , Christen Thomas , Allocco Dominic J. , Kim Won-Keun 
Published: June 2021

Abstract
Background
Transcatheter aortic valve implantation (TAVI) has become standard treatment for elderly patients with symptomatic severe aortic valve stenosis. The ACURATE neo AS study evaluates 30-day and 1-year clinical and hemodynamic outcomes in patients treated with the ACURATE neo2 valve.

Methods
The primary endpoint of this single-arm multicenter study is 30-day all-cause mortality. Other key endpoints include device performance, echocardiographic measures assessed by an independent core laboratory, and VARC-2 clinical efficacy and safety endpoints through 12 months.

Results
The study enrolled 120 patients (mean age 82.1 ± 4.0 years; 67.5% female, mean baseline STS score 4.8 ± 3.8%). The VARC-2 composite safety endpoint at 30 days occurred in 13.3% of patients. All-cause mortality was 3.3% at 30 days and 11.9% at 1 year. The 30-day stroke rate was 2.5% (disabling stroke 1.7%); there were no new strokes between 30 days and 12 months. The rate of permanent pacemaker implantation was 15.0% (18/120) at 30 days and 17.8% (21/120) at 1 year. No patients required re-intervention for valve-related dysfunction and there were no cases of valve thrombosis or endocarditis. Patients demonstrated significant improvement in mean aortic valve gradient (baseline 38.9 ± 13.1 mmHg, 1 year 7.8 ± 3.5 mmHg; P < 0.001 in a paired analysis). In the overall population, paravalvular leak was evaluated at 1 year as none/trace in 60.5%, mild in 37.0%, and moderate in 2.5%; no patients had severe PVL.

Conclusions
One-year outcomes from the ACURATE neo AS study support the safety and performance of TAVI with the ACURATE neo2 valve.

Graphic Abstract
A third hand to the surgeon: the use of an endoscope holding arm in endonasal sinus surgery and well beyond
Authors: Hintschich Constantin A. , Fischer René , Seebauer Caroline , Schebesch Karl-Michael , Bohr Christopher , Kühnel Thomas 
Published: June 2021

Abstract
Background
Extended endoscopic endonasal operations of the sinuses and the frontal skull base require a bimanual action of the surgeon in many cases. Thus, typically an assistant guides the endoscope and centers the field of view. In this study, we investigate in which cases an endoscope holding arm can be used alternatively.

Materials and methods
The electromagnetic system ENDOFIXexo was used in different surgical interventions of the paranasal sinuses and beyond questioning ergonomics and geometrical limitations. The realized degrees of freedom were documented, and a topography of possible applications compiled.

Results
The presented system is limited by the anatomy of the anterior ethmoid and dynamic working conditions in the sagittal direction. Especially in extended interventions in the posterior ethmoid, in which parts of the nasal septum have been resected and a static position of the endoscope is desired the surgeon can greatly benefit from the robotic arm. Moreover, through the high flexibility of the endoscopic arm surgeries of the pharynx and larynx were performed, questioning the current gold standard of microscope-assisted surgical procedures.

Conclusion
Under the impression of an urging staff shortage and due to its unlimited patience, the ENDOFIXexo arm seems promising. Taking into account the complex anatomy and the limited access, we especially see a favorable field of application in the surgery of the pituitary gland and skull base tumors.
Analysis of barley mutants ert-c.1 and ert-d.7 reveals two loci with additive effect on plant architecture
Authors: Lu Qiongxian , Dockter Christoph , Sirijovski Nick , Zakhrabekova Shakhira , Lundqvist Udda , Gregersen Per L. , Hansson Mats 
Published: June 2021

Abstract
Main conclusion
Both mutant ert-c.1 and ert-d.7 carry T2-T3 translocations in the Ert-c gene. Principal coordinate analyses revealed the translocation types and translocation breakpoints. Mutant ert-d.7 is an Ert-cErt-d double mutant.

Abstract
Mutations in the Ert-c and Ert-d loci are among the most common barley mutations affecting plant architecture. The mutants have various degrees of erect and compact spikes, often accompanied with short and stiff culms. In the current study, complementation tests, linkage mapping, principal coordinate analyses and fine mapping were conducted. We conclude that the original ert-d.7 mutant does not only carry an ert-d mutation but also an ert-c mutation. Combined, mutations in Ert-c and Ert-d cause a pyramid-dense spike phenotype, whereas mutations in only Ert-c or Ert-d give a pyramid and dense phenotype, respectively. Associations between the Ert-c gene and T2-T3 translocations were detected in both mutant ert-c.1 and ert-d.7. Different genetic association patterns indicate different translocation breakpoints in these two mutants. Principal coordinate analysis based on genetic distance and screening of recombinants from all four ends of polymorphic regions was an efficient way to narrow down the region of interest in translocation-involved populations. The Ert-c gene was mapped to the marker interval of 2_0801to1_0224 on 3HL near the centromere. The results illuminate a complex connection between two single genes having additive effects on barley spike architecture and will facilitate the identification of the Ert-c and Ert-d genes.
fGAAM: A fast and resizable genetic algorithm with aggressive mutation for feature selection
Authors: Rejer Izabela , Jankowski Jarosław 
Published: June 2021

AbstractThe paper introduces a modified version of a genetic algorithm with aggressive mutation (GAAM) called fGAAM (fast GAAM) that significantly decreases the time needed to find feature subsets of a satisfactory classification accuracy. To demonstrate the time gains provided by fGAAM both algorithms were tested on eight datasets containing different number of features, classes, and examples. The fGAAM was also compared with four reference methods: the Holland GA with and without penalty term, Culling GA, and NSGA II. Results: (i) The fGAAM processing time was about 35% shorter than that of the original GAAM. (ii) The fGAAM was also 20 times quicker than two Holland GAs and 50 times quicker than NSGA II. (iii) For datasets of different number of features, classes, and examples, another number of individuals, stored for further processing, provided the highest acceleration. On average, the best results were obtained when individuals from the last 10 populations were stored (time acceleration: 36.39%) or when the number of individuals to be stored was calculated by the algorithm itself (time acceleration: 35.74%). (iv) The fGAAM was able to process all datasets used in the study, even those that, because of their high number of features, could not be processed by the two Holland GAs and NSGA II.
Long-term efficacy and safety of CT-P6 versus trastuzumab in patients with HER2-positive early breast cancer: final results from a randomized phase III trial
Authors: Stebbing Justin , Baranau Yauheni V. , Baryash Valery , Manikhas Alexey , Moiseyenko Vladimir , Dzagnidze Giorgi , Zhavrid Edvard , Boliukh Dmytro , Pikiel Joanna , Eniu Alexandru E. , Li Rubi K. , Tiangco Beatrice , Lee Sang Joon , Kim Sunghyun 
Published: June 2021

Abstract
Purpose
Equivalent efficacy was demonstrated for the biosimilar CT-P6 and trastuzumab following neoadjuvant therapy for patients with human epidermal growth factor receptor-2 (HER2)-positive early breast cancer. Following adjuvant treatment, efficacy and safety were comparable between treatments. We report updated safety and efficacy data after up to 3 years’ follow-up.

Methods
Following neoadjuvant chemotherapy with CT-P6/trastuzumab, patients underwent surgery and continued receiving adjuvant CT-P6/trastuzumab. The primary endpoint (previously reported) was pathological complete response. Time-to-event analyses (disease-free survival [DFS], progression-free survival [PFS], and overall survival [OS]), study drug-related and cardiac adverse events, and immunogenicity were assessed during post-treatment follow-up.

Results
Most patients entered the follow-up period (CT-P6: 259 [95.6%]; trastuzumab: 269 [96.8%]). After a median follow-up of 38.7 (CT-P6) and 39.6 (trastuzumab) months, medians were not reached for time-to-event parameters; estimated hazard ratios (HRs) and 3-year survival rates were similar between groups. Estimated HRs (95% confidence intervals) for CT-P6 versus trastuzumab were 1.23 (0.78–1.93) for DFS, 1.31 (0.86–2.01) for PFS, and 1.10 (0.57–2.13) for OS (intention-to-treat population). Safety findings were comparable between groups for the overall study and follow-up period, including study drug-related cardiac disorders (CT-P6: 22 [8.1%] patients; trastuzumab: 24 [8.6%] patients [overall]) and decreases in left ventricular ejection fraction. Immunogenicity was similar between groups.

Conclusion
The similarity of the time-to-event analyses between CT-P6 and trastuzumab supports the equivalence in terms of efficacy established for the primary endpoint. CT-P6 was well tolerated, with comparable safety and immunogenicity to trastuzumab.
ClinicalTrials.gov: NCT02162667 (registered June 13, 2014)
Regional inequality of resident income and its determinants: A case study of Zhejiang Province, China
Authors: Zhang Qinchen 
Published: June 2021

AbstractThis paper focuses on the regional inequality of resident income in local China at the county or district level, and Zhejiang Province is set as the empirical case. It takes a geographic approach to detect the spatial distribution pattern of resident income, and explore the relationship with regional-specific socio-economic factors. The analytical framework proposed by us has been proved appropriate by the case study. Our study results show that in terms of the resident income level, there exists great regional gap in Zhejiang with the northeast wealthy cluster and much poorer cluster in the southwest. The disposable income of residents is mainly determined by commerce prosperity, urban intensity and technological capacity of local areas, while the effect of regional income, household deposits and industrial production are much less or no significant. Our findings for Zhejiang lead us to suggest that those local states seeking to improve people’s livelihood and income should not solely rely on the industrial or manufacturing expansion, but pay more attention to business environment, urban construction and indigenous innovation. Also, to narrow the significant regional gap of resident income, extra efforts should be made to push the regional cooperation system in economic development.
Questioning Racial and Gender Bias in AI-based Recommendations: Do Espoused National Cultural Values Matter?
Authors: Gupta Manjul , Parra Carlos M. , Dennehy Denis 
Published: June 2021

AbstractOne realm of AI, recommender systems have attracted significant research attention due to concerns about its devastating effects to society’s most vulnerable and marginalised communities. Both media press and academic literature provide compelling evidence that AI-based recommendations help to perpetuate and exacerbate racial and gender biases. Yet, there is limited knowledge about the extent to which individuals might question AI-based recommendations when perceived as biased. To address this gap in knowledge, we investigate the effects of espoused national cultural values on AI questionability, by examining how individuals might question AI-based recommendations due to perceived racial or gender bias. Data collected from 387 survey respondents in the United States indicate that individuals with espoused national cultural values associated to collectivism, masculinity and uncertainty avoidance are more likely to question biased AI-based recommendations. This study advances understanding of how cultural values affect AI questionability due to perceived bias and it contributes to current academic discourse about the need to hold AI accountable.
Oesophageal balloon positioning by echocardiography to guide positive pressure ventilation
Authors: Betello Marco , Giraud Raphael , Bendjelid Karim 
Published: June 2021

AbstractUnderstanding the respiratory mechanics of ARDS patients is crucial to avoid ventilator-induced lung injury (VILI), and this is much more challenging if not only lung compliance is altered but the whole compliance of the respiratory system is abnormal, as in obese patients. We face this problem daily in the ICU, and to optimize ventilation, we estimate respiratory mechanics using an oesophageal balloon. The balloon position is crucial to assess reliable values. In the present technical note, we describe the use of echocardiography to confirm the correct position of this instrument.
The missing asymmetry in the Polish house price cycle: an analysis of the behaviour of house prices in 17 major cities
Authors: Brzezicka Justyna , Łaszek Jacek , Olszewski Krzysztof , Wisniewski Radoslaw 
Published: June 2021

AbstractThis paper investigates the house price cycle in 17 major cities in Poland, analysing separately prices of newly constructed housing and prices in the existing stock. We apply the Andre, Gupta and Mwamba (2019) framework and test the deepness and steepness of the cycles. Deepness concerns the relative magnitude of peaks and downturns, while steepness determines, how fast peaks or downturns are reached. When at least one of those measures is not symmetric, there is asymmetry in the cycle. We apply the triples test and the entropy test and find little evidence for asymmetry, mostly only in small cities. This seems to be intriguing, because usually there are asymmetries, for example slow price increases end in sudden drops. The explanation for the smooth cycle in the Polish housing market are a still not satisfied demand for housing and continuously growing wages. Banks issued mortgages only to the more affluent people, which were able to pay back the mortgage. Additionally, two housing subsidy schemes helped to keep house prices stable, when the situation in the global economy worsened, which might have led to price drops.
Thermal decomposition of tris(O-ethyldithiocarbonato)-antimony(III)—a single-source precursor for antimony sulfide thin films
Authors: Eensalu Jako S. , Tõnsuaadu Kaia , Adamson Jasper , Oja Acik Ilona , Krunks Malle 
Published: June 2021

AbstractThermal decomposition of tris(O-ethyldithiocarbonato)-antimony(III) (1), a precursor for Sb2S3thin films synthesized from an acidified aqueous solution of SbCl3and KS2COCH2CH3, was monitored by simultaneous thermogravimetry, differential thermal analysis and evolved gas analysis via mass spectroscopy (TG/DTA-EGA-MS) measurements in dynamic Ar, and synthetic air atmospheres.1was identified by Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR) measurements, and quantified by NMR and elemental analysis. Solid intermediates and final decomposition products of1prepared in both atmospheres were determined by X-ray diffraction (XRD), Raman spectroscopy, and FTIR.1is a complex compound, where Sb is coordinated by three ethyldithiocarbonate ligands via the S atoms. The thermal degradation of1in Ar consists of three mass loss steps, and four mass loss steps in synthetic air. The total mass losses are 100% at 800 °C in Ar, and 66.8% at 600 °C in synthetic air, where the final product is Sb2O4.1melts at 85 °C, and decomposes at 90–170 °C into mainly Sb2S3, as confirmed by Raman, and an impurity phase consisting mostly of CSO22−ligands. The solid-phase mineralizes fully at ≈240 °C, which permits Sb2S3to crystallize at around 250 °C in both atmospheres. The gaseous species evolved include CS2, C2H5OH, CO, CO2, COS, H2O, SO2, and minor quantities of C2H5SH, (C2H5)2S, (C2H5)2O, and (S2COCH2CH3)2. The thermal decomposition mechanism of1is described with chemical reactions based on EGA-MS and solid intermediate decomposition product analysis.
The clinical relevance of laboratory prognostic scores for patients with radiosurgically treated brain metastases of non-pulmonary primary tumor
Authors: Cho Anna , Untersteiner Helena , Fitschek Fabian , Khalaveh Farjad , Pruckner Philip , Pavo Noemi , Rössler Karl , Dorfer Christian , Gatterbauer Brigitte , Höller Christoph , Schmidinger Manuela , Frischer Josa M. 
Published: June 2021

Abstract
Purpose
To investigate the clinical value of the inflammation based prognostic scores for patients with radiosurgically treated brain metastases (BM) originating from non-pulmonary primary tumor (PT).

Methods
A retrospective analysis of 340 BM patients of different PT origin (melanoma, breast, gastrointestinal, or genitourinary cancer) was performed. Pre-radiosurgical laboratory prognostic scores, such as the Neutrophil-to-Lymphocyte Ratio (NLR), the Platelet-to-Lymphocyte Ratio (PLR), Lymphocyte-to-Monocyte Ratio (LMR), and the modified Glasgow Prognostic Score (mGPS), were investigated within 14 days before the first Gamma Knife radiosurgical treatment (GKRS1).

Results
In our study cohort, the estimated survival was significantly longer in patients with NLR < 5 (p < 0.001), LMR > 4 (p = 0.001) and in patients with a mGPS score of 0 (p < 0.001). Furthermore, univariate and multivariate Cox regression models revealed NLR ≥ 5, LMR < 4 and mGPS score ≥ 1 as independent prognostic factors for an increased risk of death even after adjusting for age, sex, KPS, extracranial metastases status, presence of neurological symptoms and treatment with immunotherapy (IT) or targeted therapy (TT).

Conclusions
Summarizing previously published and present data, pre-radiosurgical mGPS and NLR groups seem to be the most effective and simple independent prognostic factors to predict clinical outcome in radiosurgically treated BM patients.