bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of adjuvant drugs on the analgesic activity of opioid morphine analgesics and compound RU-1205
Authors: Spasov Alexander A. , Grechko Olesya Iu. , Eliseeva Natalya V. , Lifanova Yuliya V. , Aleksandrenkova Angelina N. 
Published: September 2021

Introduction: Adjuvant medications can be used to increase the analgesic effect of opioid analgesics, reduce the manifestation of side effects, and also for premedication. This paper provides information on the effect of clonidine, haloperidol, metocloparmide, diazepam, midazolam on opioid analgesics: - morphine and the selective kappa-opioid agonist compound RU-1205.
Materials and methods: A probable interaction between RU-1205, morphine and adjuvant drugs in pain behaviors was carried out on the model of somatogenic pain. 95 male mice received either RU-1205 (5 mg/kg, i.p.) and morphine (1 mg/kg, i.p.) separately or in combination with haloperidol (0.45 mg/kg, i.p.); midazolam (0.3 mg/kg, i.p.); diazepam (1 mg/kg, i.p.); metoclopramide (5 mg/kg, i.p.), and clonidine (1 mg/kg, i.p.). The analgesic effect was assessed by tail flick test. Registration of the latent period of the reaction was carried out 30, 60 and 90 minutes after the adjuvant drug administration.
Results: When studying the interaction with morphine, it was found that clonidine, haloperidol and metoclopramide enhanced the effects; diazepam offset them, and midazolam had no affect on the analgesic properties. In the course of the studies, RU-1205 showed an increase in analgesic activity when combined with clonidine, a slight increase with midazolam, and a decrease when co-administered with diazepam. Haloperidol had no influence on the effect of RU-1205, while metoclopramide both potentiated and reduced the analgesic effect.
Discussion: Pharmacodynamic and pharmacokinetic interactions of RU-1205 with an α2AR agonist, benzodiazepine receptor agonists, D2P antagonist, and σ-receptor blocker were established.
Conclusion: The presented data make it possible to more accurately formulate ideas about the localization and action mechanism of the kappa-agonist of opioid receptors, the compound RU-1205.
The Influence of Sex, Body Mass Index, and Age on Cartilage Metabolism Biomarkers in Patients After Anterior Cruciate Ligament Injury and Reconstruction
Authors: Rodriguez Kazandra M. , Curran Michael Thomas , Palmieri-Smith Riann M. 
Published: September 2021

Context
Serum biomarkers may allow for the early identification of posttraumatic osteoarthritis after anterior cruciate ligament (ACL) injury and reconstruction. Homeostasis of matrix-metalloproteinase-3 (MMP-3) and type II collagen turnover biomarkers (C2C:CPII ratio) is believed to be compromised in individuals with ACL injury, yet the influence of sex, body mass index (BMI), and age on these biomarkers before and after ACL reconstruction remains unknown.

Objective
To determine the relationship of sex, BMI, and age with serum levels of MMP-3 and C2C:CPII before and after ACL reconstruction.

Design
Descriptive laboratory study.

Setting
Laboratory.

Patients or Other Participants
Thirty-two (females = 18, males = 14) individuals with ACL injuries.

Main Outcome Measure(s)
Demographic variables and blood samples were collected before surgery and at return to activity. Serum was extracted from the blood and assays were used to quantify MMP-3 and C2C:CPII. Generalized linear mixed-effects regression models were used to assess the relationships between sex, BMI, age, time, and participant on the outcome variables.

Results
A significant time × sex interaction was identified for MMP-3 levels (P = .021), whereby MMP-3 levels were higher in males at return to activity (males, 2.71 ± 0.59 ng/mL; females, 1.92 ± 0.60 ng/mL; P = .017). Males also had higher MMP-3 levels at return to activity when compared with presurgery levels (P = .009). A main effect for age demonstrated that older age was associated with higher MMP-3 levels. No significant main or interaction effects were noted for C2C:CPII levels.

Conclusions
Upregulation of MMP-3 serum levels may occur after ACL reconstruction, particularly in males, which may have deleterious consequences for the cartilage matrix. Sex, BMI, and time did not influence C2C:CPII ratios, but further research with larger sample sizes is needed to confirm these findings.
Increased Detection of Mycobacterium tuberculosis Disease Using a Tissue-Based Laboratory-Developed Polymerase Chain Reaction Assay Compared to Standard Diagnostics
Authors: Mackow Natalie A. , Abi-Raad Rita , Kerantzas Christopher A. , Hui Pei , Malinis Maricar , Azar Marwan M. 
Published: September 2021

ABSTRACT.
Standard diagnostics for Mycobacterium tuberculosis (MTB) including acid-fast bacilli (AFB) smear and culture, and Xpert™ MTB/RIF real-time Polymerase Chain Reaction (RT-PCR; Xpert) have variable sensitivity and/or long turnaround times. We describe the clinical performance of a laboratory-developed tissue-based MTB PCR compared with AFB culture and Xpert using a composite reference standard (CRS). Over an 8-year period, MTB PCR was performed on pulmonary, pleural, or lymph node specimens for 36 patients. Of these, 11 met criteria for confirmed/probable MTB using CRS. MTB PCR was positive in 100% (11/11), AFB cultures were positive in 73% (8/11), and Xpert in 0% (0/4). MTB PCR was negative in 25 cases of “No MTB” (100% specific). The MTB PCR assay resulted faster than positive AFB culture (mean time 4.3 versus 21.2 days). Tissue-based MTB PCR was associated with increased and rapid detection of MTB, improving clinical sensitivity in strongly suspected MTB cases.
Linguagem de programação visual para avaliação de modelos BIM na concepção do projeto
Authors: Brígitte Giovanna Tomczinski Novellini , Ruschel Regina Coeli 
Published: September 2021

Apesar da crescente difusão do BIM no Brasil, sua aplicação continua arraigada às etapas mais avançadas do desenvolvimento projetual, desperdiçando o enorme impacto que a tecnologia possui ao subsídio de decisões qualificadas tomadas ainda na fase de concepção. Neste sentido, este artigo discute o uso combinado de ferramentas de autoria de modelos e de ferramentas baseadas em linguagem de programação visual no auxílio à etapa de concepção, objetivando favorecer, com ênfase na relação humano-ambiente, a avaliação das derivações apresentadas pelos sistemas generativos. A proposta foi validada no contexto do projeto de habitação de interesse social e investigou a influência das alternativas de modelagem BIM na avaliação através de um indicador de projeto específico, o Gradiente de Intimidade. Em termos metodológicos, esta pesquisa baseia-se num estudo exploratório estruturado em duas etapas: (i) desenvolvimento de rotina na ferramenta Dynamo® e sua aplicação no Autodesk Revit; (ii) a avaliação dos resultados quanto a limitações, potencialidades e usabilidade. A proposição destas rotinas mostrou-se muito promissora ao avanço da pesquisa no propósito de estabelecer um processo no qual um conjunto de rotinas será aplicado de forma automatizada sobre inúmeros modelos de informação, gerados pelo computador, objetivando auxiliar o projetista a escolher o melhor resultado através da sobreposição dos indicadores de patterns aplicáveis ​​à algoritmização.
Propiedades psicométricas del cuestionario de autoeficacia académica (CAA) en universitarios del área de la actividad física
Authors: Flores Rico Francisco Javier , Ordonez Bencomo Edgar Francisco , Medina López Héctor Luis , Santos Sambrano Gilberto 
Published: September 2021

Para comprender los aspectos cognitivos y afectivos depende en gran medida por el gran interés que le imprimen las instancias educativas al ofrecer estrategias didácticas que permita alcanzar el máximo de los conocimientos pero sin duda alguna, la participación decidida del estudiante será determinante en su proceso de enseñanza aprendizaje favoreciendo en gran medida sus competencias académicas como parte elemental y coadyuvar su desarrollo profesional e integral. En el apartado de la Psicología educativa, los aspectos de autoeficacia y ansiedad por el simple hecho de su definición muestra un sentido controversial en el sujeto al no identificar puntualmente el estado del comportamiento que deriva dicha actitud. Esto ha generado importantes avances de investigación que contribuyan a elevar sustancialmente los métodos de enseñanza que se requiere en la actualidad.
Abstract
To understand the cognitive and affective aspects depends to a great extent on the great interest that the educational institutions print when offering didactic strategies that allow to reach the maximum of the knowledge but without doubt, the participation Determined by the student will be decisive in their teaching learning process by favoring to a large extent their academic competencies as an elementary part and to contribute to their professional and integral development. In the section of the educational psychology, the aspects of self-efficacy and anxiety by the simple fact of its definition show a controversial sense in the subject by not identifying punctually the state of the behavior that derives this attitude. This has generated important research advances that contribute to substantially elevating the teaching methods currently required.
A INCLUSÃO NA EDUCAÇÃO SUPERIOR: ACESSO E PERMANÊNCIA DE ESTUDANTES COM DEFICIÊNCIA EM INSTITUIÇÕES DE ENSINO SUPERIOR PÚBLICAS
Authors: Santos Bassi Tânia Mara dos 
Published: September 2021

O artigo discute a inclusão de estudantes público- alvo da Educação Especial, especialmente com deficiência, em Instituições Públicas de Educação Superior (IES). Aborda as políticas públicas nacionais materializadas em documentos legais que fundamentam a educação formal desse alunado nesse nível de ensino. Além de tratar sobre o acesso e permanência, traz outro aspecto concernente a esses: a acessibilidade, que compreende o ambiente físico, a comunicação, os materiais pedagógicos, as metodologias a fim de garantir a equidade que pressupõe os preceitos inclusivos. A metodologia seguiu abordagem qualitativa, a partir de pesquisa bibliográfica e documental, bem como o levantamento de dados das sinopses estatísticas do Instituto Nacional de Estudos e Pesquisas Educacionais Anísio Teixeira (INEP) acerca do número de matrículas desse grupo nas IES, entre 2014-2019. Os resultados expressaram que, a inclusão na Educação Superior está em curso, haja vista o crescente quantitativo de matrículas desses estudantes a nível nacional e estadual nas IES. Todavia, de 2018 para 2019, enfocando as IES públicas de Mato Grosso do Sul, houve diminuição matrículas desses educandos. Em suma, as IES vêm adequando-se às políticas públicas de inclusão, sobretudo no que tange à acessibilidade neste nível de ensino. Acesso e permanência estão atrelados, a Lei n.º 13.409/2016 favorece o acesso a alguns grupos minoritários, como em voga, à Educação Superior; entretanto, deve-se atentar às condições de permanência a fim de oportunizar a esses estudantes participação nas ações do ensino, pesquisa e extensão próprias da Educação Superior. Este estudo traduz a necessidade de pesquisas na temática inclusão.
Understanding The Simpsons
Authors: Fink Moritz 
Published: September 2021

Accolades such as "the best TV show of the twentieth century" or "the longest-running scripted series on American prime-time television" have elevated The Simpsons to the pop culture pantheon, while also suggesting the very vintage character of the program. But the label "The Simpsons" refers not just to a show that seems to belong to a bygone television era, it implies a rich narrative universe, including a set of iconic figures, familiar across continents and generations.
Through the lens of transmedia studies, Understanding The Simpsons traces the franchise’s trajectory, exploring how one of the most popular comedy series of all time has redefined the intersections between corporate media and participatory culture, as the kernel of its cult meaning.
Cuándo y cómo iniciar la insulinización
Authors: Ezcurra Loiola Patxi 
Published: September 2021

La insulinización en las personas con diabetes mellitus tipo 2 (PDM2) debe realizarse en el momento del diagnóstico cuando existe clínica de insulinopenia y cifras elevadas de glucemia basal (> 300 mg/dl) o hemoglobina glucosilada (HbA1c  )> 10 %. También cuando no se logran los objetivos individualizados del paciente tras triple terapia con antidiabéticos no insulínicos (ADNI), valorando previamente las comorbilidades de la PDM2 y sus preferencias. El comienzo se realizará preferentemente con insulina basal 10 UI o 0,2 UI/kg de peso en obesos administrada antes de acostarse. El ajuste de la dosis se realiza en función de las glucemias basales, priorizando el autoajuste de la dosificación por parte de la PDM2. Deben mantenerse los tratamientos con ADNI al comenzar con insulina basal y se aconseja retirar la sulfonilurea y las meglitinidas con la introducción de la insulina prandial. Debieran contemplarse estrategias para las distintas barreras al inicio de la insulinización por parte de las PDM2.
EDUCAÇÃO CATÓLICA DA INFÂNCIA ÍTALO-BRASILEIRA EM COLOMBO-PARANÁ (1915 – 1965)
Authors: Motin Mara Francieli , Souza Gizele de 
Published: September 2021

O propósito deste artigo abarca uma discussão sobre a infância da cidade de Colombo/PR, entre 1915 e 1965, perpassando temáticas da educação, imigração italiana e congregações católicas. A partir deste contexto, objetivamos elencar quais as ações educacionais, além dos muros escolares, que os Padres Passionistas, em conjunto com congregações femininas, propuseram à infância. Utilizamos como fontes o Livro Tombo da Igreja Matriz, uma carta de paroquianos colombenses destinada ao Bispo de Curitiba, além de fotografias e jornais, analisados não só pelo prisma das representações desta instituição, mas também em como ela precisou se adaptar ao lugar e produzir. Percebe-se que Igreja e comunidade, amparadas em características étnicas, trabalharam juntas, projetando e ampliando ações para a formação educacional católica da infância.
PALAVRAS-CHAVE: Educação Católica. Imigração Italiana. História da Infância. Congregações Católicas.
COTIDIANO DE CRIANÇAS POMERANAS NA EDUCAÇÃO INFANTIL
Authors: Berwaldt Myrna Gowert Madia , Nogueira Gabriela Medeiros 
Published: September 2021

Este artigo apresenta dados de uma pesquisa que teve por objetivo conhecer como um grupo de crianças pomeranas vivenciou a cultura lúdica e enfrentou os desafios no cotidiano, em uma turma de nível II da Educação Infantil de uma escola de Ensino Fundamental, ao longo de 2019. A investigação foi realizada por meio da análise de documentos e da etnografia, tendo a sociologia da infância como referencial teórico. Dentre os resultados encontrados, observamos que a língua foi um fator impactante no processo de inserção na escola, pois dois terços das crianças falavam apenas a Língua Pomerana e um terço era bilíngue em português e pomerano. No decorrer do ano, a Língua Portuguesa foi prevalecendo, o que teve como consequência o silenciamento da Língua Pomerana, caracterizando uma relação de subordinação de uma cultura à outra.
PALAVRAS-CHAVE: Crianças e Infância. Comunidade Pomerana. Educação Infantil. Cultura Lúdica.
DAMPAK PANDEMI COVID-19 TERHADAP EKONOMI DAN LINGKUNGAN FISIK DI DESA WISATA DI BALI
Authors: Lily Dianasari Dewa Ayu Made 
Published: September 2021

The COVID-19 pandemic had a very significant impact on tourism in Bali, as evidenced by decreasing tourist visits to Bali. The decline of tourist visits had an impact on the economy and the physical environment in Bali, especially in Tourism Villages.
The survey was conducted on the local communities involved in the management of tourist villages in Bali as many as 100 respondents to get the community's perception of the impact given to the economy and the physical environment during the COVID-19 pandemic. The sampling technique used was proportionally stratified random sampling and analyzed by using confirmatory factor analysis.
Community perceptions in tourist villages in Bali about the impact of the COVID-19 pandemic on the economy have a negative impact. This can be seen from the highest average value which has the highest loading factor matrix value of 0,773. The perception of communities in tourist villages in Bali about the impact of covid 19 on the environment tends to have a positive impact. This can be seen from the results of the highest loading factor value in a positive statement with a value of 0,868; that is cleaner water conditions in the tourist village.
PENGARUH MEDIA SOSIAL DAN DAYA TARIK WISATA TERHADAP KEPUTUSAN BERKUNJUNG WISATAWAN DOMESTIK DI PANTAI MELASTI, BALI
Authors: Krisnayani Ni Komang , Liestiandre Hanugerah Kristiono , Pranjaya I Gusti Putu Ade 
Published: September 2021

The emergence of various kinds of social media has an impact on the industrial revolution in the tourism sector, marked by the ease of accessing information through social media. The tourism transformation of the 4.0 era changes the entire cycle of the tourism ecosystem, especially in terms of the dissemination and consumption of information on social media related to travel activities. The purpose of this research is to see the impact of media social and tourist attraction on the domestic tourist visit-decision in Melasti Beach, Badung. This research was designed using quantitative methods with multiple linear regression analysis. Using qualitative and quantitative data, with total sample of 250 respondents from domestic tourists visiting Melasti Beach. Sampling was done by distributing 30 questionnaires to visitors at Melasti Beach. The analysis technique was tested using the classical assumption test. Most of the respondents came from Jakarta, most of whom were women. The results of this study indicate that there is an influence between social media and tourist attraction on the decision to visit domestic tourists classified as positive.
NSOF AND ROTARY-WING PLATFORMS – INTEGRATED OR JOINT?
Authors: UNGUREANU Dan-Marian , MOLDOVAN Ioan 
Published: September 2021

Abstract: There is today a burgeoning discussion about how Romanian Naval Special Operations Forces (RNSOF) is supported in maritime operations by the conventional means of the Romanian Navy rotary-wing platforms. As part of this approach, we set out to analyze the regulatory framework for ensuring the support of naval aviation in the execution of NSOF missions. Thus, we will study the evolution of the cooperation of the ROU Navy Helicopter Group and NSOF from the perspective of regulations on cooperation, training, common standard operating procedures, references on standardization and safety in the execution of training and missions in the maritime environment. This research addresses an aspect of special operations that has yet to be explained adequately. To achieve this goal, we will describe how these operations are conducted in NATO countries, which have integrated maritime aviation in support of naval forces for special operations in the maritime environment. According to the specified causes to achieve our objectives, we will search for solutions to compensate or reduce the gap between necessity and reality. Through comparative analysis and documentation on the strategies used by foreign military forces, with similar roles and missions, we will provide solutions that will cover an area that can vary from adapting procedures to establishing the need to develop certain regulations. Our study is addressed to persons involved or interested in the military field and special naval operations and aims to highlight the importance of developing the NSOF capacity to cooperate with integrated maritime aviation and adjusted to the requirements of the execution of special maritime operations. Taking these recommendations into account will increase the effectiveness of NSOF maritime operations with the support of rotary-wing platforms while ensuring the transition to a robust/ real joint NSOF capability in response to existing threats in the Black Sea.
Rancang Bangun Mekanisme Peningkat Putaran Bertenaga Sepeda Statis Dengan Keluaran 2700 Rpm Pada Sistem Alternator
Authors: Sindu Artha Gede Andhika , Herwanto Djoko , Amal Fatkhulloh  
Published: September 2021

Dalam engine run, dapat disimulasikan memanfaatkan putaran roda sepeda statis untuk memenuhi kebutuhan putaran alternator. Namun, keterbatasan kayuhan otot kaki manusia belum mampu mencapai rpm yang diinginkan. Dengan demikian dibutuhkan mekanisme peningkat putaran. Berdasarkan beberapa identifikasi masalah yang akan menjadi batasan masalah adalah bagaimana merancang mekanisme peningkat putaran bertenaga sepeda statis dengan keluaran 2700 rpm. Dari hasil rancangan ini, didapatkan knurling wheel dengan permukaan diamond pattern knurling berdiameter 60 mm sebagai penerus putaran roda sepeda berdiameter 660 mm. Roda gigi yang dipilih adalah roda gigi lurus dimana roda gigi penggerak berjarak bagi 120 mm, jumlah gigi 60 dan roda gigi yang digerakkan berjarak bagi 60 mm dengan jumlah gigi 30 untuk menaikkan putaran dari knurling wheel. Poros yang digunakan berdiameter 20 mm dengan ukuran pasak 7x7. Bearing yang digunakan adalah tipe ball bearing dengan nomor bantalan 6004. Pada sabuk dan puli, perancang memilih sabuk v tipe A nomor 35 dengan panjang keliling sabuk 889 mm dan puli penggerak berdiameter 127 mm. Penyangga (roda gigi, puli dan alternator) yang digunakan bermaterial S45C dengan yield strength 343 N/mm2. Dari hasil perhitungan dan perancangan yang telah dilakukan, alat yang dibuat bekerja dengan baik sesuai kriteria perancang. Sehingga rancangan ini dapat digunakan untuk membantu menaikkan putaran dari input putaran roda sepeda.