bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative exploration of eye movement desensitisation and reprocessing versus cognitive behavioural therapy for post‐traumatic stress disorder in Pakistan: Insights from a full‐fledged randomised controlled trial
Authors: Khan Anwar , Madihie Amalia bt , Ullah Faseeh , Abid Omer , Awan Khizra Hafeez 
Published: January 2025

AbstractBackground and AimPost‐traumatic stress disorder (PTSD) is a psychiatric disorder, triggered by traumatic events. Modern evidence‐based psychotherapies, such as eye movement desensitisation and reprocessing (EMDR) and cognitive behavioural therapy (CBT), have been widely used for the treatment of PTSD. However, limited evidence is available regarding their comparative efficacy, especially in the context of Pakistan. Given this context, a single‐blinded, two‐group randomised controlled trial was conducted to compare the efficacy of EMDR and CBT in treating patients with PTSD in Pakistan.MethodsA consecutive sample of 80 patients was selected. Patients were randomly allocated to EMDR and CBT in accordance with covariate‐adaptive stratified randomisation. This study was carried out at two mental health rehabilitation centres in the capital city of Peshawar, Pakistan. Data on PTSD symptoms and other related aspects were collected through the Clinician‐Administered PTSD Scale for DSM‐5. Data were analysed using descriptive statistics, non‐inferiority analysis and a general linear model repeated measures ANOVA.ResultsResults regarding treatment fidelity revealed that both therapies were carried out in adherence to treatment protocols. Treatment efficacy results showed that PTSD symptoms were high during the baseline stage of therapy (CAPS‐5 mean score of 98.80 for EMDR and 100.50 for CBT) but decreased to low in the follow‐up stage (CAPS‐5 mean score of 30.20 for EMDR and 34.20 for CBT); however, overall, EMDR therapy was found to be non‐inferior and more efficacious than CBT.ConclusionThe findings of this study hold significant implications at both individual and policy levels. EMDR therapy emerges as a viable alternative to CBT for the treatment of PTSD in Pakistan. Therefore, the study recommends the adoption of EMDR therapy as an effective treatment option for PTSD in Pakistan.
Examining Artificial Intelligence Policies in Counsellor Education
Authors: Campbell Laurie O. , Frawley Caitlin , Lambie Glenn W. , Cabrera Karina S. , Vizcarra Bryanna D. 
Published: January 2025

ABSTRACTAimsThis study investigated counsellor education Council for Accreditation of Counseling and Related Educational Programs (CACREP) programs generative artificial intelligence (AI) policies in doctoral‐level counselor education programs. We aimed to contribute to emerging research on the use of generative AI within counselor education.MethodsA content analysis of the policies was conducted along with a linguistic analysis of the policies to determine the authenticity, tone, and analytical nature of the University, and program policies.ResultsA content analysis of generative artificial intelligence usage policies within doctoral counselor education programs indicated that only five programs had program‐specific generative artificial intelligence policies. Most programs utilized University policies or usage guidance.ConclusionSuggestions for practice include providing definitional clarity of the different types of AI to reduce potential frustration for learners. Further, programs should consider developing a program‐specific policy since the counseling profession requires a high level of ethical responsibility to best serve clients.
Assessment of the Effects of Harvesting Period of Clusia fluminensis Planch. and Triana Fruits on Neutralization of the Toxic Activities of Bothrops jararacussu Snake Venom
Authors: Rodrigues da Silva Aldo , Pietroluongo Márcia , Rodrigues da Silva Ana Cláudia , Sanchez Eladio Flores , do Amaral Bruno Sérgio , Anholeti Maria Carolina , Lobão Adriana Quintella , Valverde Alessandra Leda , de Paiva Selma Ribeiro , Fuly André Lopes 
Published: January 2025

ABSTRACTSnakebite envenomation is a public health issue that can lead to mortality and physical consequences. It is estimated that 5.4 million venomous snake bites occur annually, with 130 000 deaths and 400 000 amputations. The available treatment is serotherapy, which is inefficient in preventing physical sequelae. Thus, it is critical to seek efficient treatments. Here, we assessed the efficacy of fruits from Clusia fluminensis harvested at different time periods over 1 year against the toxicity of Bothrops jararacussu venom. The extracts were incubated with B. jararacussu venom, and the in vitro (coagulant and proteolytic) and in vivo (hemorrhagic, edematogenic, and lethal) activities of the venom were assessed. Moreover, B. jararacussu venom was injected 30 min before the extract injection to evaluate hemorrhagic activity. Little variation in the chemical composition of the fruit extracts from C. fluminensis or their ability to inhibit the toxic effects of B. jararacussu venom was observed. When administered after venom injection, the C. fluminensis extracts inhibited hemorrhage caused by B. jararacussu venom. Thus, the plant collection period should be considered to achieve the highest antivenom potential.
Mechanochemical Deracemization: A Sustainable Approach to Enantiopurity
Authors: Gieling Job , Wéry Guillaume , Lopes Chrystal , de Meester Joséphine , Brandel Clément , Cartigny Yohann , Leyssens Tom , Baier Daniel M. 
Published: January 2025

AbstractWe introduce mechanochemical deracemization (MCDR) as a novel strategy for obtaining enantiopure compounds. This study demonstrates the successful transposition of six archetypical deracemization reactions from a solvent‐based to a solvent‐minimized ball milling environment. The scope includes a ketone, isoindolinones, imines, an ester, and an inorganic compound, all of which deracemized successfully. Key parameters such as milling material, ball number and size, the use of a bulk material and liquid‐assisted grinding (LAG) were systematically investigated, revealing their crucial role. Quantitative enantiomeric excesses (ee) were achieved, while reaction times were reduced by up to 97 % and solvent consumption by as much as 100 %. This work establishes MCDR as a versatile, sustainable pathway to enantiopure compounds. By highlighting the generalizability of this approach and its huge potential for minimizing waste, this study provides the foundation for future advancements in mechanochemical deracemization.
Conceptualizing Coproduced Climate Research as Care: Practical Lessons Learned With Women Farmland‐Owners in the Central Midwest United States
Authors: Shenk Linda , Eells Jean , Gutowski William J. , Franz Kristie , Robinson Danielle 
Published: January 2025

ABSTRACTThis article's team of interdisciplinary researchers and conservation educator‐practitioners learned with, and from, a group of women farmland‐owners regarding how to conceptualize coproduced climate research by putting “care” at the center—care for the soil, for relationships, for data. We outline the creation and evolution of a storytelling‐based conservation program that allowed our diverse group to discover how the language of care could integrate climate analysis, conservation, and relationship‐building to foster tangible solutions. As a result of the project, the women landowners took actions that supported social‐environmental resilience—from planting cover crops to fostering watershed/neighborhood relationships. Our diverse group of women landowners and researchers had very different experiences with conservation and often very different views on climate change itself, but, through storytelling and the language of care, we not only coproduced knowledge but also created relationships and action. This article outlines specific practices for how to inflect a coproduced process for climate resilience with practices that promote care and yield action projects.
Prevalence and determinants of metabolic syndrome in 2338 childhood cancer survivors: A Dutch Childhood Cancer Survivor LATER 2 study
Authors: Bolier Melissa , de Winter Demi T.C. , Pluimakers Vincent G. , Fiocco Marta , van den Berg Sjoerd A.A. , Bresters Dorine , van Dulmen‐den Broeder Eline , van der Heiden‐van der Loo Margriet , Höfer Imo , Janssens Geert O. , Kremer Leontien C.M. , Loonen Jacqueline J. , Louwerens Marloes , van der Pal Heleen J. , Pluijm Saskia M.F. , Tissing Wim J.E. , van Santen Hanneke M. , de Vries Andrica C.H. , van der Lely Aart‐Jan , van den Heuvel‐Eibrink Marry M. , Neggers Sebastian J.C.M.M. 
Published: January 2025

AbstractBackgroundBecause the occurrence of metabolic syndrome (MetS) might contribute to childhood cancer survivor’s excess risk of cardiovascular disease, the authors assessed the prevalence and determinants of MetS in the Dutch Childhood Cancer Survivor Study (DCCSS‐LATER2) cohort.MethodsIn total, 2338 adult childhood cancer survivors (CCS) were cross‐sectionally assessed for the prevalence of MetS, using the Lifelines cohort (N = 132,226 adults without a history of cancer) as references. The prevalence of MetS was clinically assessed using existing classifications, as well as an alternative method using dual‐energy x‐ray absorptiometry fat% instead of waist circumference to define abdominal adiposity. Logistic regression models, adjusted for age and sex, were used to investigate the association between the presence of MetS and both cohorts. Demographic, lifestyle, and treatment determinants of MetS were identified through multivariable logistic regression.ResultsThe survivor cohort (median age, 34.7 years, median follow‐up time, 27.1 years) showed increased adjusted odds ratio (aOR) for MetS (modified National Cholesterol Education Program Adult Treatment Panel III criteria), as compared to the reference cohort (aOR, 2.07; 95% confidence interval [CI], 1.85–2.32). Compared to these criteria, the alternative method identified 57 additional survivors with MetS (395 of 2070 [19.1%] vs. 452 of 1960 [23.1%], respectively). Age (odds ratio [OR], 1.07; 95% CI, 1.04–1.10, per year increase), smoking (OR, 1.46; 95% CI, 1.04–2.04), low physical activity (OR, 1.48; 95% CI, 1.05–2.09), abdominal radiotherapy (OR, 2.13; 95% CI, 1.01–4.31; >30 Gy), cranial radiotherapy (OR, 2.89; 95% CI, 1.67–4.96; 1–25 Gy; and OR, 2.44; 95% CI, 1.30–4.47; >25 Gy), total body irradiation (OR, 6.17; 95% CI, 3.20–11.76), and underlying central nervous system tumor (OR, 1.78; 95% CI, 1.21–2.60) were associated with MetS.ConclusionThe high risk of MetS in CCS, combined with several potential modifiable factors, underscores the need for timely identification and intervention strategies to mitigate the long‐term cardiovascular risks in CCS.
Comorbid conditions and survival among Black women with ovarian cancer
Authors: Richards Alicia R. , Johnson Courtney E. , Montalvo Nachalie Ramos , Alberg Anthony J. , Bandera Elisa V. , Bondy Melissa , Collin Lindsay J. , Cote Michele L. , Hastert Theresa A. , Haller Kristin , Khanna Namita , Marks Jeffrey R. , Peters Edward S. , Qin Bo , Staples Jeanine , Terry Paul D. , Lawson Andrew , Schildkraut Joellen M. , Peres Lauren C. 
Published: January 2025

AbstractBackgroundBlack women with epithelial ovarian cancer (EOC) have worse survival and a higher burden of comorbid conditions compared with other racial groups. This study examines the association of comorbid conditions and medication use for these conditions with survival among Black women with EOC.MethodsIn a prospective study of 592 Black women with EOC, the Charlson comorbidity index (CCI) based on self‐reported data, three cardiometabolic comorbidities (type 2 diabetes, hypertension, and hyperlipidemia), and medication use for each cardiometabolic comorbidity were evaluated. Cox proportional hazards regression models were used to examine the association of comorbid conditions and related medication use with all‐cause mortality while adjusting for relevant covariates overall and by histotype (high‐grade serous [HGS]/carcinosarcoma vs. non‐HGS/carcinosarcoma) and stage (I/II vs. III/IV).ResultsA CCI of ≥2 was observed in 42% of the cohort, and 21%, 67%, and 34% of women had a history of type 2 diabetes, hypertension, and hyperlipidemia, respectively. After adjusting for prognostic factors, a CCI ≥2 (vs. 0; hazard ratio [HR], 1.33; 95% confidence interval [CI], 1.04–1.71) and type 2 diabetes (HR, 1.42; 95% CI, 1.10–1.84) were associated with an increased risk of mortality. The increased risk of mortality for type 2 diabetes was present specifically among women with HGS/carcinosarcoma (HR, 1.47; 95% CI, 1.10–1.97) and among women with stage III/IV disease (HR, 1.47; 95% CI, 1.10–1.98). The authors did not find evidence that hypertension, hyperlipidemia, or medication use for the cardiometabolic comorbidities meaningfully impacted survival.ConclusionComorbid conditions, especially type 2 diabetes, had a significant adverse impact on survival among Black women with EOC.
National Cancer Institute comprehensive cancer centers: Significant improvement in mortality and symptom control, further opportunities remain toward health equity
Authors: Barrett Nadine , Mesa Ruben 
Published: January 2025

The article by Thamm et al. reports that studies predominantly reported superior outcomes at comprehensive cancer centers (CCCs) compared to non CCCs in metrics related to patient mortality and survival, with non‐CCCs potentially being both more accessible and lower cost. In this editorial, the authors discuss bidirectional collaborative learning opportunities between both type of cancer center that may benefit cancer patients at both types of centers.
Unveiling loose smut resistance in Indian bread wheat germplasm: Gene postulation and pedigree analysis
Authors: Bhandhari Divya , Bala Ritu , Srivastava Puja , Kaur Jaspal , Sharma Vineet Kumar 
Published: January 2025

AbstractThe present study is aimed at the postulation of Ut genes in loose smut‐resistant bread wheat (Triticum aestivum L.) genotypes and establishing a correlation with their pedigree. Loose smut caused by Ustilago segetum tritici (Ust) is an internal seed‐borne disease of wheat that can be managed through chemical seed treatment. However, due to the absence of evident symptoms, seed treatment is not a regular practice in the farming community. Thus, the use of resistant cultivars is an efficient and sustainable approach for the management of loose smut of wheat. The majority of current wheat cultivars are susceptible to loose smut. Therefore, there is a pressing need for the development of resistant cultivars, which requires the identification of resistant donors with known resistant genes. In this study, field screening for 3 years resulted in the identification of 124 bread wheat genotypes conferring stable resistance against Ust race T11. Molecular marker‐based identification of Ut genes (Ut4–Ut11) revealed the presence of these genes either singly or in combination in 118 genotypes. Among them, six genotypes showed different combinations of five Ut genes, namely, WH 1218 and HI 1633 (Ut4, Ut6, Ut8, Ut9, Ut11), HD 3377 (Ut4, Ut6, Ut8, Ut9, Ut10), WH 1218 and HI 1633 (Ut4, Ut6, Ut9, Ut10, Ut11), and HD 3226 (Ut4, Ut5, Ut6, Ut9, Ut11). The genotypes with multiple genes for loose smut resistance can be used as donors for transferring the resistance into the high‐yielding cultivars. Furthermore, the pedigree of each genotype was analyzed to find the gene source of the postulated Ut genes. None of the genotypes showed consistent association with the gene source of the postulated Ut gene present in the pedigree. Thus, no association between molecular marker‐based postulation and pedigree of genotypes was inferred. However, the root pedigree of common parents revealed five putative sources of loose smut resistance, that is, Chris, Thatcher, Federation, New‐Thatch, and Ostka‐Galicyjska, in most of the genotypes under evaluation in the present study.
Pipeline ShiftAddNet: An FPGA‐Based CNN Implementation With Low Hardware Consumption Targeting Constrained Devices
Authors: Kiat Wei‐Pau , Kong Lee Wai , Tan Hung‐Khoon , Ng Hui‐Fuang 
Published: January 2025

ABSTRACTShiftAddNet is a recently proposed multiplier‐less CNN that replaces conventional multiplication with cheaper shift and add operations, which makes it suitable for hardware implementation. In this paper, we present the first implementation of ShiftAddNet FPGA inference core, which achieves low area consumption and fast computation. ShiftAddNet combined the convolutional layer of the DeepShift‐PS (denoted as Shift‐Accumulate, sac) and AdderNet (denoted as Add‐Accumulate, aac) into a single computational stage. Due to this reason, there are data dependencies between the sac and aac, which prohibits them from being executed in parallel, resulting in more operations compared to other multiplier‐less CNNs like DeepShift‐PS and AdderNet. To overcome this performance bottleneck, we proposed a novel technique to allow pipeline processing between sac and aac, effectively reducing the latency. The proposed ShiftAddNet‐18 was evaluated on a small ResNet‐18, achieving 11.37 ms of latency per image, which is 69.21% faster than the original version that takes 19.24 ms. On a denser network, the proposed pipeline ShiftAddNet‐101 requires only 61.92 ms as compared to the original version of 98.85 ms, showing a latency reduction of 37.1%. Compared to the state‐of‐the‐art multiplier‐less CNN core (e.g., AdderNet), our work is 20% slower in latency but provides higher accuracy and consumes less DSP.
Endobronchial Ultrasound Guided Transbronchial Needle Aspiration of Solitary Lung Nodules and the Triple Diagnosis Technique: Does Triple Diagnosis Improve Diagnostic Accuracy?
Authors: Sinclair Jason , Preston Peace , Esebua Magda , Nguyen Van , Caruso Carla , Kunin Jeffrey , Layfield Lester J. 
Published: January 2025

ABSTRACTBackgroundEndobronchial ultrasound guided Transbronchial Needle Aspiration (EBUS‐TBNA) is the predominant method for investigation of centrally located solitary pulmonary nodules. The method is associated with good to excellent diagnostic sensitivity and specificity with the positive predictive value of the test reaching 100% and reported negative predictive values for FNA of pulmonary nodules ranging from 53% to 97%. The impact of correlating cytologic results with imaging and clinical findings for improvement of negative predictive value has been poorly studied.Materials and MethodsAn electronic search of the cytology records of the University of Missouri was made for all EBUS‐TBNA specimens with surgical pathology follow‐up. The associated imaging and clinical impressions were obtained. The clinical impression/assessment was the assessment given in the clinical summary section of the clinical note. Results of each technique were designated as benign, indeterminate, or malignant. Diagnostic triplets were constructed, and calculation of sensitivity, specificity, positive predictive value and negative predictive value was performed for each modality as well as the triplets.ResultsSearch revealed a total of 254 cases with definitive surgical follow up. Thirty‐two of these were excluded because they were either cytologically non‐diagnostic or fell into one of the intermediate categories. One hundred sixty‐three and 84 of these cases had definitive imaging or clinical interpretive results respectively. Definitive diagnostic triplets were obtained in 58 cases (22.8%). Cytology was associated with a sensitivity of 66.7% and specificity of 81.1%. Its positive predictive value was 87.7% and its negative predictive value was 54.5%. Imaging was associated with a sensitivity of 90.7%, a specificity of 22.2%, a positive predictive value of 75.4% and a negative predictive value of 47.6% and these statistics were 96.7%, 33.3%, 78.4%, and 80.0% respectively for clinical analysis. The positive predictive value of a triplet analysis was 92.9% and the negative predictive value was 100%.ConclusionsDiagnostic triplets were obtainable in only a minority of cases, but they resulted in significant improvement in positive and negative predictive values.
An Inducible Neural Stem Progenitor Cell Model for Testing Therapeutic Interventions Against Neurodegeneration FENIB
Authors: Giustini Alessandro , Maiocchi Alice , Serangeli Ilaria , Pedrini Martina , Quintiliani Anna , Sabato Valentina , Bonato Francesca , Seneci Pierfausto , Lupo Giuseppe , Passarella Daniele , Miranda Elena 
Published: January 2025

ABSTRACTFamilial encephalopathy with neuroserpin inclusion bodies (FENIB) is a neurodegenerative pathology caused by accumulation of mutant neuroserpin (NS) polymers inside the endoplasmic reticulum (ER) of neurons, leading to cellular toxicity and neuronal death. To date, there is no cure for FENIB, and only palliative care is available for FENIB patients, underlining the urgency to develop therapeutic strategies. The purpose of this work was to create a cellular system designed for testing small molecules able to reduce the formation of NS polymers. Our results show the generation and characterisation of a novel cell culture model for FENIB based on neural stem progenitor cells (NPCs) with inducible expression of either wild type (WT) or G392E NS, a variant that causes severe FENIB. We also report the use of these novel cell lines to explore the effects of four different proteolysis targeting chimaera (PROTAC) compounds, small bivalent molecules engineered to bind to the E3 ubiquitin ligase cereblon, and to NS through a recruiting motif based on the small molecule embelin. This approach aims to enhance the degradation of mutant NS after retro‐translocation to the cytosol by facilitating its targeting to the proteasome. Our results show little toxicity and no variation in NS levels with any of the compounds tested. In conclusion, this work sets the basis for future attempts to identify molecules able to prevent NS accumulation inside the ER of cultured cells.
Compartmentalization Device of Microenvironment for Analyzing iPSCs Differentiation
Authors: Fukai Daiki , Toyoda Taro , Takao Hidekuni , Shimokawa Fusao , Terao Kyohei 
Published: January 2025

ABSTRACTThis paper reports on a microdevice for compartmentalizing the solution microenvironment that can fractionate the space surrounding spheroids during the culture and differentiation processes, with the aim of verifying the effects of cell–cell interactions in the solution microenvironment on iPS cell differentiation. In this paper, we demonstrated that spheroids of iPS cells were successfully formed on the device and fractionated their microenvironment by a detachable compartmentalization frame (DCF) formed by 3D printing technology.
Comparative Context of Hard‐Tissue Sexual Dimorphism in Early Hominins: Implications for Alpha Taxonomy
Authors: Balolia Katharine L. , Wood Bernard 
Published: January 2025

ABSTRACTSexual dimorphism is one of the main factors confounding attempts to generate sound alpha taxonomic hypotheses in the early hominin fossil record. To better understand how between‐sex variation may confound alpha taxonomic assessments, we consider some of the factors that drive hard‐tissue sexual dimorphism in extant primates. We review the socioecological correlates of body size sexual dimorphism, how sexual selection may be associated with craniofacial sexual dimorphism in the context of visual signaling, and how sex‐specific patterns of growth and development in primates contribute to intra‐specific variation. To illustrate how variation associated with inferred sexual dimorphism has the potential to confound alpha taxonomic assessments in early hominins, we focus on its impact on our understanding of a single taxon, Paranthropus boisei. We suggest that regions of the skeleton likely to be influenced by sexual selection should be avoided when generating alpha taxonomic hypotheses.