bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tailored Risk Management In Drilling & Completion: Illustrative Case Study Of A Well Campaign
Authors: Zausa F. , Masi S. , Repetto C. , Michelez J. , Rossi N. 
Published: May 2021

Risk Management (RM) is awell recognised approach to addressprojects uncertainties, to provideaccurate CAPEX estimates and tohave proactive responses tounplanned events.However, RM is often presented asa standard and repetitive process,disregard to projects diversechallenges. This acceptance is amain obstacle to its successfulimplementation, because this canlead to over complex risk studies forsimple matter or, on the contrary,scarce results for intricate issues.Drilling & Completion projectspresent a high versatility ofsituations (from a standard onshoreworkover to a very challenging deepoffshore exploratory campaign).Project challenges can be verydifferent: technical (HP/HT, newtechnologies, etc), environmental(sensitive areas, deep offshoreconditions, etc), economic (marketconditions, etc), or strategic(partnership, etc).The natural consequence is thateach project requires an adequateresponse in terms of RM. Actually,RM toolbox encompasses a numberof different studies, such as riskregisters, risk mapping, probabilisticCAPEX/schedule, fault trees, etc.Not all studies should besystematically performed. Thus, theRM approach must be tailored toeach project challenges, in order tobring the highest added value to thedecision makers.
eni Drilling, Completion &Production optimization departmenthas built an integrated RM systemthat provides a properly designedworkflow for treating each projectwith a suitable approach accordingto its maturity and other technical,environmental, economic or strategiccriteria.This paper takes advantage of aneni experience on a well campaignand describes how RM approachsupported strategic decisions on theimplementation of technologies(RSS, continuous circulating system,aluminium drill pipe, ceramicprotectors and centralisers) to reducewell operations uncertainties. Thiscase study encompasses thecomplete decision loop, from thecost/benefit analysis of eachtechnology to the measured benefitsfrom the rig operations in terms ofperformance enhancement.Finally, it substantiates the values ofRM in investment decision byaddressing RM in a practical way.This case study will definitely helpto spread a RM culture withinproject management organizations.
Developed Equation For Fitting ASTM Distillation Curves
Authors: Chasib Dr. Khalid Farhod 
Published: May 2021

The present work deals with fitting literature data of ASTM Distillation curves and obtain a new correlation suitable to use in modeling when optimizing the refining processes, such as distillation, FCC, catalytic reforming, hydrotreating, etc.
The results showed that the values predicted by a new correlation are very good agreement with data of literature and the range of mean overall deviation (%MOD) is (0.305-0.585).
Improvement Of Rheological Properties Of Al-Dura Asphaltic Binders Using Chemical Modifiers
Authors: Ammouri Dr. Qays Mothanna 
Published: May 2021

Treating Iraqi asphaltic binder produced from Al – Dura refinery by either oxygenation or 4% sulfur or 4% nitric acid improved the penetration from 241 mm down to 92 mm, and from (68 - 63 ) mm also it and improved the softening point from 39 OC up to 49 OC, 50 OC, 52 OC respectively and it, improved the ductility from 73 cm up to 100 cm, 102 cm, 106 cm respectively.
When subjecting these treated asphaltic binders to Iraqi environmental conditions, the rheological properties will not changed during 14 months. The studied environmental conditions
were included when subjecting the treated asphaltic binder samples to (sunlight, water immersion, 1kg load, both sunlight and 1kg load, both water immersion and 1kg load, both sunlight and water immersion and both sunlight, water immersion and 1kg load). Compared with base asphaltic binder supplied directly from refinery without treatment which failed immediately during one week.
Pengembangan Sistem Informasi Pengolahan Stok Barang Toko Dual Comm Tanjungpinang Berbasis Client Server
Authors: Setiawan Hendi 
Published: May 2021

Pengolahan stok barang di Toko Dual Comm saat ini dalam pengolahan data barang masuk dan keluar meliputi barang pembelian atau penambahan stok barang dan juga untuk keluar sebagai penjualan. Agar proses pengolahan data barang masuk dan keluar dapat berjalan dengan efektif dan efisien, maka sudah seharusnya untuk menggunakan aplikasi sistem informasi pengolahan data barang masuk dan keluar yang dapat menangani proses barang masuk dan keluar. Dengan dibentuknya suatu sistem dengan proses terkomputerisasi berbasis client server, maka diharapkan dapat mengatasi masalah-masalah yang telah terjadi.Dalam melakukan penelitian ini, metode pengembangan perangkat lunak yang digunakanadalah metode waterfall yang terdiri dari rekayasa sistem, analisis, desain, implementasi, pengujian dan pemeliharaan. Aplikasi ini dibangun dengan Bahasa pemograman Netbeans dan PhpMyAdmin. Hasil dari penelitian ini adalah sistem perangkat lunak yang berbasis client server untuk proses pengolahan data barang masuk dan keluar. Dengan adanya aplikasi ini diharapkan untuk mempermudah dan mempercepat kinerja pihak Toko Dual Comm terutama dibagian accounting dalam proses barang masuk dan keluar.
Business intelligence and analytics to support management in construction: a systematic literature review
Authors: Lopes Anderson Brunheira , Boscarioli Clodis 
Published: May 2021

Management is essential to meet the requirements defined in a project, such as business objectives and stakeholder expectations. The computational tools in the Business Intelligence and Analytics category have great potential to contribute to management, providing important managerial information about the business. Tools of this type are widely used in the most varied sectors of the industry, but in the construction industry, the scenario is different, with much to move foward. Therefore, the present work presents a survey of the Business Intelligence and Analytics tools applicable to the civil construction sector and its uses. To this end, a systematic literature review was conducted, which analyzed 1407 articles from six databases, where several applications were identified, the most relevant in the area of cost management, budget preparation and work safety.
Austeridade em Portugal: medidas implementadas e seu impacto no acesso, eficiência e qualidade do serviço nacional de saúde
Authors: Nunes Alexandre Morais , Matos Andreia Afonso de 
Published: May 2021

Em abril de 2011, uma grave crise econômica e social eclodiu em Portugal, levando o país a solicitar ajuda financeira ao Fundo Monetário Internacional, à Comissão Europeia e ao Banco Central Europeu que, em troca, exigiu o cumprimento de um conjunto de várias medidas de austeridade constante de um memorando. Parte dessas medidas focalizaram o Serviço Nacional de Saúde, ao qual foi exigido um corte na despesa e um conjunto de reformas promotoras de eficiência que gerassem economias por meio da melhor realocação dos recursos e da redução do investimento. Este artigo pretende, através da análise da literatura e das políticas de saúde implementadas, mostrar os resultados/efeitos da austeridade e os passos já dados no período pós crise. Como resultados se verificou algumas melhorias ao nível da eficiência, mas graves problemas no acesso aos serviços de saúde. Em conclusão pode-se afirmar que a austeridade foi necessária, mas foi pensada apenas para aquele momento e não numa perspectiva de construção da política de saúde para o futuro.
Émergence et trajectoire des controverses entourant l’enseignement de l’histoire au Québec et au Canada
Authors: Lanoix Alexandre , Warren Jean-Philippe 
Published: May 2021

L’article s’intéresse aux débats entourant l’enseignement de l’histoire au Québec et au Canada en puisant dans les écrits qui portent sur les controverses scientifiques et publiques. Il présente l’émergence et l’évolution de controverses au Canada et au Québec de la fin des années 1980 à nos jours. Il propose une réflexion sur les facteurs qui ont fait en sorte que la controverse a été soulevée avec beaucoup plus de force au Québec et qu’elle a mené à des changements significatifs dans les programmes de formation.
L’impact des représentations sociales de l’enseignement de l’histoire et de ses finalités sur les pratiques des enseignant⋅e⋅s au Québec : recherche exploratoire
Authors: Jadoulle Jean-Louis 
Published: May 2021

Cette étude multicas porte sur les pratiques observées de cinq enseignant⋅e⋅s d’histoire et leurs représentations de l’enseignement de leur discipline et de ses finalités. Elle suggère un tableau enrichi des finalités attribuées par les enseignante⋅s d’histoire du Québec en mettant en évidence trois profils : polyvalent, intellectuel et pratique. Elle invite à remettre en question le constat généralement admis à propos de la prédominance des pratiques magistrocentrées au Québec. Selon nos observations, trois enseignants sur cinq développent des pratiques qui relèvent de l’apprentissage-recherche. Cette étude montre également l’existence d’écarts entre les paradigmes de référence qui marquent les représentations et les pratiques observées. Les finalités assignées à l’enseignement de l’histoire semblent de meilleurs prédicteurs des pratiques.
Construction of an immune-related signature with prognostic value for colon cancer
Authors: Lv Yunxia , Wang Xinyi , Ren Yu , Fu Xiaorui , Li Taiyuan , Jiang Qunguang 
Published: May 2021

Background
Colon cancer is the third most common malignant tumor in the world. Although immunotherapy has been used in cancer treatment, there is still no first-line immunotherapy method for colon cancer. Therefore, it is essential to search for potential immunotherapy targets and molecular biomarkers for early diagnosis and prognosis.

Methods
In this study, we downloaded transcriptome data from The Cancer Genome Atlas (TCGA) and immune-related genes from the ImmPort database. Then we filtered genes with prognostic value and constructed an immune-related signature. Patients were classified into low- and high-risk groups, and we exerted a series of analysis between the signature and clinical phenotypes. Additionally, we used protein-protein interaction networks, gene set enrichment analysis (GSEA) and single-sample gene-set enrichment analysis (ssGSEA) to explore the underlying mechanism of this signature. Furthermore, the accuracy of this signature was verified, using two data sets from Gene Expression Omnibus (GEO).

Results
We selected 12 immune-related genes to construct the immune-related signature. Low-risk group had a higher level of immunity compared to high-risk group. The expression level of HLA genes and checkpoint-related genes were statistically different in low- and high-risk groups. This signature showed its prognostic value in TCGA cohort and 2 GEO data sets. The signature also had strong correlation with TNM classification, stage, survival state and lymphatic invasion. The mechanism of the signature may be related to several transcription factors and CD8+ T cell in the tumor microenvironment.

Conclusion
In conclusion, this immune-related signature is of great prognosis value for colon cancer and its biofunction might be correlated with HLA genes, checkpoint-related genes and high-infiltrating T cells in tumor tissues.
Variance of vegetation coverage and its sensitivity to climatic factors in the Irtysh River basin
Authors: Han Feifei , Yan Junjie , Ling Hong-bo 
Published: May 2021

Background
Climate change is an important factor driving vegetation changes in arid areas. Identifying the sensitivity of vegetation to climate variability is crucial for developing sustainable ecosystem management strategies. The Irtysh River is located in the westerly partition of China, and its vegetation cover is more sensitive to climate change. However, previous studies rarely studied the changes in the vegetation coverage of the Irtysh River and its sensitivity to climate factors from a spatiotemporal perspective.

Methods
We adopted a vegetation sensitivity index based on remote sensing datasets of high temporal resolution to study the sensitivity of vegetation to climatic factors in the Irtysh River basin, then reveal the driving mechanism of vegetation cover change.

Results
The results show that 88.09% of vegetated pixels show an increasing trend in vegetation coverage, and the sensitivity of vegetation to climate change presents spatial heterogeneity. Sensitivity of vegetation increases with the increase of coverage. Temperate steppe in the northern mountain and herbaceous swamp and broadleaf forest in the river valley, where the normalized difference vegetation index is the highest, show the strongest sensitivity, while the desert steppe in the northern plain, where the NDVI is the lowest, shows the strongest memory effect (or the strongest resilience). Relatively, the northern part of this area is more affected by a combination of precipitation and temperature, while the southern plains dominated by desert steppe are more sensitive to precipitation. The central river valley dominated by herbaceous swamp is more sensitive to temperature-vegetation dryness index. This study underscores that the sensitivity of vegetation cover to climate change is spatially differentiated at the regional scale.
TCF7L2 rs7903146 polymorphism association with diabetes and obesity in an elderly cohort from Brazil
Authors: Bride Lais , Naslavsky Michel , Lopes Yamamoto Guilherme , Scliar Marilia , Pimassoni Lucia HS , Sossai Aguiar Paola , de Paula Flavia , Wang Jaqueline , Duarte Yeda , Passos-Bueno Maria Rita , Zatz Mayana , Imbroisi Valle Errera Flávia 
Published: May 2021

Background
Type 2 diabetes mellitus (T2DM) and obesity are complex pandemic diseases in the 21st century. Worldwide, the T allele rs7903146 in the TCF7L2 gene is recognized as a strong GWAS signal associated with T2DM. However, the association between the C allele and obesity is still poorly explored and needs to be replicated in other populations. Thus, the primary objectives of this study were to evaluate the TCF7L2 rs7903146 association with T2DM according to BMI status and to determine if this variant is related to obesity and BMI variation in a cohort of elderly Brazilians.

Methods
A total of 1,023 participants from an elderly census-based cohort called SABE (Saúde, Bem Estar e Envelhecimento—Health, Well-Being and Aging) were stratified by BMI status and type 2 diabetes presence. The TCF7L2 genotypes were filtered from the Online Archive of Brazilian Mutations (ABraOM—Online Archive of Brazilian Mutations) database, a web-based public database with sequencing data of samples of the SABE’s participants. Logistic regression models and interaction analyses were performed. The BMI variation (∆BMI) was calculated from anthropometric data collected in up to two time-points with a ten-year-assessment interval.

Results
The association between the rs7903146 T allele and T2DM was inversely proportional to the BMI status, with an increased risk in the normal weight group (OR 3.36; 95% CI [1.46–7.74]; P = 0.004). We confirmed the T allele association with risk for T2DM after adjusting for possible confound ing variables (OR 2.35; 95% CI [1.28–4.32]; P = 0.006). Interaction analysis showed that the increased risk for T2DM conferred by the T allele is modified by BMI (Pinteraction = 0.008), age (Pinteraction = 0.005) and gender (Pinteraction = 0.026). A T allele protective effect against obesity was observed (OR 0.71; 95% CI [0.54–0.94]; P = 0.016). The C allele increased obesity risk (OR 1.40; 95% CI [1.06–1.84]; P = 0.017) and the CC genotype showed a borderline association with abdominal obesity risk (OR 1.28; 95% CI [1.06–1.67]; P = 0.045). The CC genotype increased the obesity risk factor after adjusting for possible confounding variables (OR 1.41; 95% CI [1.06–1.86]; P = 0.017). An increase of the TT genotype in the second tertile of ∆BMI values was observed in participants without type 2 diabetes (OR 5.13; 95% CI [1.40–18.93]; P = 0.009) in the recessive genetic model.

Conclusion
We confirmed that the rs7903146 is both associated with T2DM and obesity. The TCF7L2 rs7903146 T allele increased T2DM risk in the normal weight group and interacted with sex, age and BMI, while the C allele increased obesity risk. The TT genotype was associated with a lesser extent of BMI variation over the SABE study’s 10-year period.
Magnetic Assembly of a Multifunctional Guidance Conduit for Peripheral Nerve Repair
Authors: Antman‐Passig Merav , Giron Jonathan , Karni Moshe , Motiei Menachem , Schori Hadas , Shefi Orit 
Published: May 2021

AbstractNerve growth conduits are designed to support and promote axon regeneration following nerve injuries. Multifunctionalized conduits with combined physical and chemical cues, are a promising avenue aimed at overcoming current therapeutic barriers. However, the efficacious assembly of conduits that promote neuronal growth remains a challenge. Here, a biomimetic regenerative gel is developed, that integrates physical and chemical cues in a biocompatible “one pot reaction” strategy. The collagen gel is enriched with magnetic nanoparticles coated with nerve growth factor (NGF). Then, through a remote magnetic actuation, highly aligned fibrillar gel structure embedded with anisotropically distributed coated nanoparticles, combining multiple regenerating strategies, is obtained. The effects of the multifunctional gels are examined in vitro, and in vivo in a 10‐mm rat sciatic nerve injury model. The magneto‐based therapeutic conduits demonstrate oriented and directed axonal growth, and improve nerve regeneration in vivo. The study of multifunctional guidance scaffolds that can be implemented efficiently and remotely provides the foundation to a novel therapeutic approach to overcome current medical obstacles for nerve injuries.
Advanced High Entropy Perovskite Oxide Electrocatalyst for Oxygen Evolution Reaction
Authors: Nguyen Thi Xuyen , Liao Yi‐Cheng , Lin Chia‐Chun , Su Yen‐Hsun , Ting Jyh‐Ming 
Published: May 2021

AbstractA new type of lanthanum‐based high entropy perovskite oxide (HEPO) electrocatalyst for the oxygen evolution reaction is reported. The B‐site lattices in the HEPO consist of five consecutive first‐row transition metals, including Cr, Mn, Fe, Co, and Ni. Equimolar and five non‐equimolar HEPO electrocatalysts are studied for their OER electrocatalytic performance. In the five non‐equimolar HEPOs, the concentration of one of the five transition metals is doubled in individual samples. The performances of all the HEPOs outperform the single perovskite oxides. The optimized La(CrMnFeCo2Ni)O3 HEPO exhibits an outstanding OER overpotential of 325 mV at a current density of 10 mA cm−2 and excellent electrochemical stability after 50 h of testing.
An Engineered Protein Adhesive with Properties of Tissue Integration and Controlled Release for Efficient Cartilage Repair
Authors: Zhang Jinrui , Li Bo , Zuo Jianlin , Gu Rui , Liu Bin , Ma Chao , Li Jingjing , Liu Kai 
Published: May 2021

AbstractCartilage damage is a prevalent health concern among humans. The inertness of cartilage, the absence of self‐healing properties, and the lack of appropriate repair materials that integrate into the tissue pose a significant challenge for cartilage repair. Thus, it is important to develop novel soft biomaterials with strong tissue adhesion and chondrogenic capabilities for cartilage repair. Herein, a new type of protein adhesive is reported that exhibits superior cartilage repair performance. The material is fabricated by the electrostatic combination of chondroitin sulfate (CS) and positively charged elastin‐like protein, which is derived from natural components of the extracellular matrix (ECM). The adhesive showed robust adhesion properties on different tissue substrates, offering a favorable environment for cartilage tissue integration. Noncovalent bonding between CS molecules in the glue allows for its controlled release, which is required for efficient chondrogenic differentiation. When implanted into a rat model of cartilage defect, this protein adhesive exhibited beneficial healing effects, as evidenced by enhanced chondrogenesis, sufficient ECM production, and lateral integration. Therefore, this engineered protein complex is a promising candidate for translational application in the field of cartilage repair.
Preparation, Structure, and Reactivity of Pseudocyclic β‐Trifluorosulfonyloxy Vinylbenziodoxolone Derivatives
Authors: Yoshimura Akira , Huss Christopher D. , Liebl Mackenzie , Rohde Gregory T. , Larson Scott M. , Frahm Gunnar B. , Luedtke Mattew W. , Schumacher Tanner J. , Gardner Zachary S. , Zhdankin Viktor V. , Postnikov Pavel S. , Yusubov Mekhman S. , Kitamura Tsugio , Saito Akio 
Published: May 2021

AbstractPseudocyclic β‐trifluorosulfonyloxy vinylbenziodoxolones were prepared starting from hydroxybenziodoxolones and alkynes in the presence of trifluoromethanesulfonic acid. The reaction of these compounds with azide anion leads to β‐azido vinylbenziodoxolones as products of vinylic nucleophilic substitution in which addition‐elimination reactions occur and the double bond configuration is retained. The structures of β‐trifluorosulfonyloxy vinylbenziodoxolone and β‐azido vinylbenziodoxolone were established by single crystal X‐ray diffraction.magnified image
Visible Light‐Mediated Functionalization of Selenocystine‐Containing Peptides
Authors: Lapcinska Sindija , Dimitrijevs Pavels , Lapcinskis Linards , Arsenyan Pavel 
Published: May 2021

AbstractA straightforward and atom‐economic method for the functionalization of short selenocystine‐containing peptides is presented. This method is shown to be tolerant to unprotected peptides. The detailed protocol is based on the generation of a selenium radical via visible light‐initiated reaction in the presence of transition metal‐free photocatalyst. The selenium radical is further oxidized to an electrophile and trapped by N‐heterocycles. The mechanism is confirmed by NMR, HRMS, UV, EPR and cyclic voltammetry (CV) experiments and photocatalyst emission quenching studies. A visible light‐initiated reaction is employed for the synthesis of selenocysteine‐containing indole‐based macrocycles via intramolecular Se−C bond formation.magnified image
The Effects of Airfoil Thickness on Dynamic Stall Characteristics of High‐Solidity Vertical Axis Wind Turbines
Authors: Bangga Galih , Hutani Surya , Heramarwan Henidya 
Published: May 2021

AbstractThe flow physics of high solidity vertical axis wind turbines (VAWTs) is influenced by the dynamic stall effects. The present study is aimed at investigating the effects of airfoil thickness on the unsteady characteristics of high solidity VAWTs. Seven different national advisory committee for aeronautics (NACA) airfoils (0008, 0012, 0018, 0021, 0025, 0030, 0040) are investigated. A high fidelity computational fluid dynamics (CFD) approach is used to examine the load and flow characteristics in detail. Before the study is undertaken, the CFD simulation is validated with experimental data as well as large eddy simulation results with sound agreement. The investigation demonstrates that increasing the airfoil thickness is actually beneficial not only for suppressing the dynamic stall effects but also to improve the performance of high solidity turbines. Interestingly this is accompanied by a slight reduction in thrust component. The strength and radius of the dynamic stall vortex decrease with increasing airfoil thickness. The airfoil thickness strongly influences the pressure distributions during dynamic stall process, which is driven by the suction peak near the leading edge. The knowledge gained might be used by blade engineers for designing future turbines and for improving the accuracy of engineering models.