bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensitivity and Concurrent validity of the Japanese Version of the Euthymia Scale: A Clinimetric Analysis
Authors: Sasaki Natsu , Carrozzino Danilo , Nishi Daisuke 
Published: January 2021

Abstract
Background: The present study was conducted to examine the clinimetric sensitivity of the Japanese version of the Euthymia Scale (ES-J). The concurrent validity of the ES-J was also tested.Methods: A cross-sectional online survey was conducted. The Mini-International Neuropsychiatric Interview was used to determine the presence of past or current major depressive episodes (MDE). Pearson’s correlation coefficients were performed to examine the concurrent validity of the ES-J. At the same time, its clinimetric sensitivity was evaluated using both the Analysis of Variance (ANOVA) and multivariate regression models. Results: A total of 1030 eligible participants completed the survey. The ES-J differentiated healthy subjects from those with a past or current history of MDE, subjects with current MDE from those with sub-threshold symptoms of depression, and healthy participants from subjects with moderate to severe symptoms of psychological distress. The associations between the ES-J and measures of psychological well-being, resilience, life satisfaction, and social support were significantly positive. A negative relationship between the ES-J and measures of psychological distress was also found. Limitations: The main limitations included utilizing the cross-sectional design, excluding Item Response Theory analyses, using the population-based sample, and using only self-reported online questionnaires.Conclusions: The findings of the present study indicated that the ES-J is a valid and highly sensitive clinimetric index, which can be used as a screening measure in the clinical process of assessment of recovery, particularly when symptoms are expected to be mild and/or when dealing with subclinical symptoms of psychological distress and depression.
Comparative Efficacy of Intraoperative Extracorporeal Irradiated and Alcohol Inactivated Autograft Reimplantation in Management of Osteosarcomas– A Multicentre Retrospective Study.
Authors: Xu Meitao , Xu Ming , Zhang Shuai , Li Hanqing , AI Qiuchi , Yu Xiuchun , wang xuquan 
Published: January 2021

Abstract
Background: The biologic bone reconstruction in the treatment of malignant bone tumours for the limb salvage surgery has always been a controversial strategie. Vary inactivation methods, convenient, stable, curative effect and economy need to be considered. This study aims to compare the clinical efficacy between intraoperative extracorporeal irradiated and alcohol inactivated autograft reimplantation methods for limb salvage surgery with osteosarcomas. Methods: We retrospectively analysed 28 patients with osteosarcomas, 14 patients treated with intraoperative cobalt 60 irradiation and reimplantation treatment (Group A), 14 patients treated by alcohol-inactivated autograft reimplantation (Group B). The postoperative complications and clinical efficacy was compared by statistical analysis. Results: The local recurrence rate was 14.3% in each group. Complete bony union was achieved in 64.3% in group A and 71.4% in group B. The overall 5-year survival rate was 71.4% in group A and 78.6% in group B. The mean MSTS score was 25.33 ± 4.72 (range 15–30 ) in group A and 24.00 ± 5.85 (range 15–30 ) in group B. The mean ISOLS score was 25.79 ± 5.13 (range 20–36 ) in group A and 26.14 ± 5.33 (range 20–30 ) in group B. P < 0.05 was considered to indicate a significant difference, there was no difference in the long-term clinical efficacy between the extracorporeal irradiation and alcohol-inactivated methods.Conclusions: For limb salvage surgery with osteosarcomas, either intraoperative extracorporeal irradiation or alcohol-inactivated autograft repimlantation had equivalent outcomes for biological reconstruction. The alcohol-inactivated technology could be a much more convenient and cheap treatment to reconstruct bone defects. Additional studies and more case studies are needed to fully evaluate the clinical efficacy and safety of the alcohol-inactivated surgical approach.
Exogenous L-carnitine a meliorated burn-induced cellular and mitochondrial injuries of hepatocytes via recovering CPT1 activity
Authors: Li Pengtao , Xia Zhengguo , Kong Weichang , Wang Qiong , Zhao Ziyue , Ashley Arnold , Xu Jiegou , Xu Qinglian 
Published: January 2021

Abstract
Background : Impaired liver fatty acid metabolism and persistent mitochondrial dysfunction are common phenomena and associated with liver failure. Decreased serum L-carnitine, a vitamin involved in fatty-acid and energy metabolisms, has been reported in severe burn patients. The current research aimed to study the effects and mechanism of L-carnitine on mitochondrial damage and other hepatocytic injuries. Methods : Serum carnitine and indicators for hepatocytic injuries including AST, ALT, LDH, TG and OCT in severe burn patients and healthy controls were analyzed. The burn model in rats was established by skin scalding, and the carnitine was administered to the rats. The indicators mentioned above in the serum, and oil red staining, TUNEL staining and TEM observation, mitochondrial membrane potential, and CPT1 activity as well as CPT1 expression of the liver tissue were examined. HepG2 cells, treated with the CPT1 inhibitor etomoxir, were supplied with/without carnitine for 24h. The indicators mentioned above were examined, and apoptotic cells were analyzed by flow cytometry. Transcriptom high throughput sequencing of the rat liver tissues was performed, and differentially expressed genes Fabp4, Acacb, Acsm5 and Pnpla3 were further determined by RT-qPCR. Results : Significantly decreased carnitine and increased AST, ALT, LDH and OCT in the serum were detected in the severe burn patients and the scalded rats. Accumulation of TG, obvious mitochondrial shrinking, altered mitochondrial membrane potential, decreased ketogenesis and declined CPT1 activity were found in the liver tissue of the scalded rats. Administration of carnitine recovered CPT1 activity and improved all the parameters for cellular, fatty acid metabolic and mitochondrial injuries. Inhibition of CPT1 activity with etomoxir in vitro induced similar hepatocytic injuries found in the burn patients and the scalded rats, and supplementation of carnitine restored CPT1 activity and ameliorated these injuries. Differentially expressed genes Fabp4, Acacb, Acsm5 and Pnpla3 in the liver tissue and in the etomoxir-treated hepatocytes were also restored by exogenous carnitine. Conclusion : Exogenous carnitine exerts its protective effect on severe burn-induced cellular, fatty-acid metabolic and mitochondrial dysfunction of the hepatocytes via restore of CPT1 activity.
miR-548ac Inhibit Wnt5a Expression and Promotes Proliferation of Glioma Cells through the AKT/ERK Pathway
Authors: Shan Wen , Li Haonan , Lu Xu , Wu Xuting , Zhang Xinhua 
Published: January 2021

Abstract
Background

Glioma is one of the most frequently occurring and lethal primary malignant tumors. MicroRNAs (miRNAs) are a newly identified modulator involved in the formation and progression of glioma.
Methods

Stable knockdown or over-expression of miR-548ac in U87 glioblastoma multiforme (GBM) cells was used to explore the function of miR-548ac in the expression of Wnt5a. Luciferase reporter constructs were used to investigate the correlation between Wnt5a expression and miR-548ac. Cell Counting Kit-8 assays, Transwell assays, colony formation assays and flow cytometry were used to investigate the functions of Wnt5a and miR-548ac in glioma. Xenograft experiments were used to evaluate tumor growth and metastasis in vivo. Western blotting was used to assess the function of the Wnt/β-catenin pathway.
Results

miR-548ac overexpression down-regulated the proliferation, migration and invasion of GBM cells. In addition, knockdown of miR-548ac promoted expression of Wat5a, a direct target of miR-548ac, which plays an oncogenic role in glioblastoma stem cells. Reduced Wan5a expression partially rescued the miR-548ac-induced enhancement of GBM cell proliferation, migration and invasion. Kaplan–Meier curve analysis revealed that high miR-548ac expression was associated with poor prognosis of patients with GBM.
Conclusions

miR-548ac suppresses GBM progression by targeting Wan5a. The miR-548ac/Wnt5a axis may be a new potential strategy for glioma therapy.
The associations among individual factors, eHealth literacy, depression symptoms and health related quality of life among Chinese elderly: a cross-section study
Authors: Zhu Xinhong , Yang Fen 
Published: January 2021

Abstract
Background: The higher level of eHealth literacy the elderly has, the easier it is to acquire benefits of health-seeking information online. The aim of this study is to evaluate the psychometric properties of the eHealth Literacy Scale (eHEALS) and examine the associations of eHEALS scores with depression, health-related quality of life (HRQoL), lifestyles among the elderly. Methods: A survey of 6183 participants (age 60 years and above) from 17 communities were conducted in June, 2019. Participants answered questions related to socio-demographics, eHEALS, geriatric depression scale and the short-form health survey (SF-36, assessing health-related quality of life). Two mediation models were conducted. A multi-linear regression analysis was performed to explore the association between the eHEALS scores and associated factors using Statistical Package for Social Science version 20.0. Significance was obtained at 95% CI and P < 0.05.Results: Exploratory factor analysis identified one component structure, accounting for 78.52% of the total variance. The factor loadings of eHEALS ranked from 0.832 to 0.905. The Cronbach α of overall scale was 0.961. eHEALS was significant higher in men (B = 0.616, 95%CI 0.235~0.997, P = 0.002), those with living in the city (B = 1.471, 95%CI 1.064~1.878, P < 0.000), those with high educated (B = 1.713, 95%CI 1.581~1.844, P < 0.000), and those with living with family (B = 6.436, 95%CI 4.574~8.298, P < 0.000), as compared to their counterparts, respectively. Moreover, chronic diseases (B = -2.218, 95%CI -2.632~-1.804, P < 0.000) and depression symptoms (B = -0.116, 95%CI 0.153~0.078, P < 0.000) were found negatively associated with eHEALS, while actively obtaining health information positively influenced eHEALS (B = 3.350, 95%CI 2.950~3.749, P < 0.000) after adjusting socio-demographics, lifestyles and HRQoL. Furthermore, depression symptoms had direct and indirect effects on HRQoL, as mediated by eHealth literacy.Conclusions: The eHEALS was a valid and reliable survey tool. As eHealth literacy was a protector for the aged, efforts to improve the older adults’ eHEALS scores can help to main health status. Therefore, healthcare providers formulate effective programs to improve eHealth literacy for the elderly, which can bring benefits for health aging.
Big Data Analytics &amp; Artificial Intelligence in Healthcare
Authors: KUMAR PRANJAL , Chauhan Siddhartha 
Published: January 2021

Abstract
Big data analysis and Artificial Intelligence have received significant attention recently in creating more opportunities in the health sector for aggregating or collecting large-scale data. Today, our genomes and microbiomes can be sequenced i.e., all information exchanged between physicians and patients in Electronic Health Records (EHR) can be collected and traced at least theoretically. Social media and mobile devices today obviously provide many health-related data regarding activity, diets, social contacts, and so on. However, it is increasingly difficult to use this information to answer health questions and, in particular, because the data comes from various domains and lives in different infrastructures and of course it also is very variable quality. The massive collection and aggregation of personal data come with a number of ethical policy, methodological, technological challenges. It should be acknowledged that large-scale clinical evidence remains to confirm the promise of Big Data and Artificial Intelligence (AI) in health care. This paper explores the complexities of big data & artificial intelligence in healthcare as well as the benefits and prospects.
Dietary Quality Indices Modify the Effects of Apolipoprotein B Polymorphisms on Cardio-Metabolic Risk Factors in type 2 Diabetes Mellitus: A Cross-Sectional Study
Authors: Karimi Elmira , Sotoudeh Gity , Rafiee Masoumeh , Koohdani Fariba 
Published: January 2021

Abstract
Background: We tried to identify the interaction between dietary quality indices and apolipoprotein B Ins/Del and EcoR1 polymorphisms on cardio-metabolic risk factors in patients with type 2 diabetes mellitus (T2DM). Methods: This cross-sectional study recruited 700 adults with T2DM who visited diabetes referral centers in Tehran. The genotypes of Ins/Del and EcoR1 single nucleotide polymorphisms (SNP) were explored via polymerase chain reaction (PCR). Dietary quality index-international (DQI-I), healthy eating index-2015 (HEI-2015) and dietary phytochemical index (DPI) were calculated by semi-quantitative food frequency questionnaire (FFQ). Lipid, inflammatory, oxidative, hormonal and anthropometric variables were determined by standard methods. Results: We observed a significant interaction between DQI-I and Ins/Del SNP on leptin (P= 0.02 for crude model and P=0.01 for adjusted model (for age, physical activity, gender, smoking and alcohol intake) and 8-iso-prostaglandin F2 α (8-iso-PGF2α) (P=0.01 for both models), DPI and EcoR1 SNP on total cholesterol (TC) (P=0.03 for both models) and between Ins/Del SNP and HEI-2015 on interleukin-18 (IL-18) (P= 0.02 for crude model and P=0.03 for adjusted model). Furthermore, in crude but not in adjusted model there were close to meaningful interactions between EcoR1 SNP and DQI-I on total antioxidant capacity (TAC) (P=0.06) and between EcoR1 SNP and HEI-2015 on serum leptin (P=0.05) and superoxide dismutase (SOD) (p=0.05) levels. Conclusion: For the first time, our finding indicated that the association between DQI-I, HEI-2015 and DPI with IL-18, TC, leptin and 8-iso-PGF2α in patients with T2DM might be dependent on Ins/Del and EcoR1 variants in ApoB gene.
Identifying diverging sustainability meanings for water policy: a Q-method study in Phoenix, Arizona
Authors: Iribarnegaray M. A. , Sullivan A. , Rodriguez-Alvarez M. S. , Brannstrom C. , Seghezzo L. , White D. D. 
Published: January 2021

Abstract
We identify and describe social perspectives on the sustainability of the water sector in the metropolitan area of Phoenix, Arizona. Using Q methodology, we find evidence for different meanings of sustainability when stakeholders are presented with concrete policy options and applications in spite of an apparently widespread agreement on the concept of sustainability itself. We put the social perspectives articulated by local stakeholders in perspective by analyzing whether they adhere to a commonly used set of sustainability principles when applied to water management and governance. The analysis indicates that although there is some level of acceptance of sustainability principles among the social perspectives identified, there are important discrepancies in the salience of different principles. Results suggest that when people are interacting in policy-making processes they tend to support their previously held own vision of the problems and that their normative considerations may be opposed to broadly accepted sustainability discourses. The different visions of water sustainability may have a direct impact on the water policy-making process depending on the position and influence of the actors involved in the governance scheme.
The Utilisation of LEGO and Other Materials as Prototyping Tools in the Co-Creation Process
Authors: Isa Siti Salwa , Liem Andre , Ali Abu , Isa Siti Suriawati 
Published: January 2021

This paper aims to investigate the usefulness of LEGO and other materials as prototyping tools in the co-creation process involving multiple stakeholders. The results demonstrate that using LEGO and other materials as prototypes in the co-creation process helps designers and stakeholders to explore, evaluate and modify ideas three-dimensionally to validate design solutions, idea generation and evaluation. This study believes that LEGO and other materials are efficient co-design prototyping tools to ensure its main purpose for team and strategy building in enhancing participant's ability to deliver more contribution during group discussions.
Keywords: Co-creation; prototyping tools; prototypes; LEGO
eISSN: 2398-4287© 2020. The Authors. Published for AMER ABRA cE-Bsby e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v5iSI3.2548
The TPSACK Framework Implementation in Measuring the Technological, Pedagogical, Skills and Content Knowledge by Using Courseware
Authors: Anuar Roslaili , Zainal Abidin Shahriman , Wan Zakaria Wan Zamani , Che Din Sharkawi 
Published: January 2021

This study examines the implementation of the TPSACK courseware, which was developed with artistic skills practice to discover the Technological, Pedagogical and Content Knowledge of the Art and Design Education (ADE) students. The courseware was developed based on Dick and Carey Instructional Design Model (2009), which addresses instruction as an entire system, focusing on the interrelationship between context, content, learning and instruction. Respondents from 130 students were gathered to analyze the courseware. Quantitative method was used to conduct a survey which is explored through SPSS. Results show a significant role in integrating technology with specific artistic skills to improve the students’ knowledge.
Keywords: TPACK framework; TPSACK framework; artistic skills
eISSN: 2398-4287© 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v5iSI3.2553
Interdisciplinary Online Hackathons as an Approach to Combat the COVID-19 Pandemic: Case Study
Authors: Braune Katarina , Rojas Pablo-David , Hofferbert Joscha , Valera Sosa Alvaro , Lebedev Anastasiya , Balzer Felix , Thun Sylvia , Lieber Sascha , Kirchberger Valerie , Poncette Akira-Sebastian 
Published: January 2021

Background
The COVID-19 outbreak has affected the lives of millions of people by causing a dramatic impact on many health care systems and the global economy. This devastating pandemic has brought together communities across the globe to work on this issue in an unprecedented manner.

Objective
This case study describes the steps and methods employed in the conduction of a remote online health hackathon centered on challenges posed by the COVID-19 pandemic. It aims to deliver a clear implementation road map for other organizations to follow.

Methods
This 4-day hackathon was conducted in April 2020, based on six COVID-19–related challenges defined by frontline clinicians and researchers from various disciplines. An online survey was structured to assess: (1) individual experience satisfaction, (2) level of interprofessional skills exchange, (3) maturity of the projects realized, and (4) overall quality of the event. At the end of the event, participants were invited to take part in an online survey with 17 (+5 optional) items, including multiple-choice and open-ended questions that assessed their experience regarding the remote nature of the event and their individual project, interprofessional skills exchange, and their confidence in working on a digital health project before and after the hackathon. Mentors, who guided the participants through the event, also provided feedback to the organizers through an online survey.

Results
A total of 48 participants and 52 mentors based in 8 different countries participated and developed 14 projects. A total of 75 mentorship video sessions were held. Participants reported increased confidence in starting a digital health venture or a research project after successfully participating in the hackathon, and stated that they were likely to continue working on their projects. Of the participants who provided feedback, 60% (n=18) would not have started their project without this particular hackathon and indicated that the hackathon encouraged and enabled them to progress faster, for example, by building interdisciplinary teams, gaining new insights and feedback provided by their mentors, and creating a functional prototype.

Conclusions
This study provides insights into how online hackathons can contribute to solving the challenges and effects of a pandemic in several regions of the world. The online format fosters team diversity, increases cross-regional collaboration, and can be executed much faster and at lower costs compared to in-person events. Results on preparation, organization, and evaluation of this online hackathon are useful for other institutions and initiatives that are willing to introduce similar event formats in the fight against COVID-19.
Bupivacaine-Fentanyl vs Ropivacaine-Fentanyl: Evaluation of two Spinal Anesthesia Protocols for Emergency Cesarean Section
Authors: Diedhiou Moustapha , Ba E.B. , Barboza D , Diouf A. , Dieng M. , Thiam O , Dia C.A. , Sarr N , Fall M.L. , Beye M.D. , Diouf E. 
Published: January 2021

Objective: Evaluation of the hemodynamic, respiratory and fetal side effects of two protocols for spinal anesthesia (P1: bupivacaine-fentanyl; P2: ropivacaine-fentanyl).
Material and Method: Prospective pseudo-randomized study comparing two spinal anesthesia protocols for emergency cesarean section conducted in the operating room of the regional hospital center of Saint Louis in Senegal. Study duration was 4 months. We studied, age, indication for Caesarean section, medical and surgical history, P1 and P2 protocols, hypotension, bradycardia, Apgar scores at birth and at 5min. Univariate and bivariate analysis was performed on the R software.
Result: A total of 115 patients were collected, with a mean age of 27.1 years (E: 15 - 45) and a standard deviation of 7.6. Indications for Caesarean section were maternal and fetal dystocia for 67 patients (58%), fetal distress for 39 parturients (34%), and pre-eclampsia for 5 patients (4%). The P1-Bupi spinal protocol was used in 42 patients (36.5%) and the P2-Ropi spinal protocol was used in 73 patients (63.5%). Anesthetic complications such as low blood pressure, bradycardia and desaturation were found in a total of 30 patients, i.e. in 26% of cases. The mean Apgar score at birth for newborns from the P1-Bupi protocol was 8 (Extremes: 7, 9); the mean Apgar score at birth for newborns from the P2-Ropi protocol was 7.5 (Extremes: 2, 10). There was a significantly negative correlation between the P1-bupi protocol and the appearance of hypotension with p-value: 0.04 and a significantly positive correlation between the P2-ropi protocol and the appearance of hypotension with p-value: 0.04.
Discussion/ Conclusion: Ropivacaine certainly has a better cardiovascular and neurological tolerance and a better efficacy in terms of analgesia. However, during caesarean sections, it is important to consider the risk of hypotension and possible fetal complications related to its use.
Keywords: Ropivacaine - Bupivacaine - Spinal anesthesia - Caesarean section