bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-translational regulation of the membrane transporters contributing to salt tolerance in plants
Authors: Gupta Amber , Shaw Birendra Prasad , Sahu Binod Bihari 
Published: October 2021

This review article summarises the role of membrane transporters and their regulatory kinases in minimising the toxicity of Na+ in the plant under salt stress. The salt-tolerant plants keep their cytosolic level of Na+ up to 10–50 mM. The first line of action in this context is the generation of proton motive force by the plasma membrane H+-ATPase. The generated proton motive force repolarises the membrane that gets depolarised due to passive uptake of Na+ under salt stress. The proton motive force generated also drives the plasma membrane Na+/H+ antiporter, SOS1 that effluxes the cytosolic Na+ back into the environment. At the intracellular level, Na+ is sequestered by the vacuole. Vacuolar Na+ uptake is mediated by Na+/H+ antiporter, NHX, driven by the electrochemical gradient for H+, generated by tonoplast H+ pumps, both H+ATPase and PPase. However, it is the expression of the regulatory kinases that make these transporters active through post-translational modification enabling them to effectively manage the cytosolic level of Na+, which is essential for tolerance to salinity in plants. Yet our knowledge of the expression and functioning of the regulatory kinases in plant species differing in tolerance to salinity is scant. Bioinformatics-based identification of the kinases like OsCIPK24 in crop plants, which are mostly salt-sensitive, may enable biotechnological intervention in making the crop cultivar more salt-tolerant, and effectively increasing its annual yield.
Influence of rotation on axisymmetric plasma equilibria: double-null DTT scenario
Authors: Del Prete Matteo , Montani Giovanni 
Published: October 2021

Abstract
We study the influence of toroidal plasma rotation on some relevant tokamak equilibrium quantities. The Grad–Shafranov equation generalised to the rotating case is analytically solved employing two different representations for the homogenous solution. Using an expression in terms of polynomials, we describe the separatrix shape by a few geometrical parameters, reproducing different plasma scenarios such as double-null and inverse triangularity. In this setting, the introduction of toroidal rotation corresponds to variations on relevant plasma quantities, most notably an enhancement of the poloidal beta. Using a more general expression in terms of Bessel functions, we reconstruct the full plasma boundary of the double-null configuration proposed for the upcoming Divertor Tokamak Test experiment, demonstrating how said configuration is compatible with different values of the plasma velocity.
Characterization of the (Cu,C)Ba2Ca3Cu4O

11+δ

single crystals grown under high pressure
Authors: He Chengping , Ming Xue , Si Jin , Zhu Xiyu , Wang Jinhua , Wen Hai-Hu 
Published: October 2021

Abstract
By using a high pressure and high temperature (3.7 GPa, 1120 ∘C) synthesis technique, we have grown (Cu,C)Ba2Ca3Cu4O

11
+
δ

single crystals. X-ray diffraction, scanning electron microscopy, resistivity, and magnetization measurements are carried out and all show that the samples have good quality. The single crystal has onset and zero-resistance transition temperatures of about 111 and 109.6 K, indicating a very narrow transition width, which is consistent with a rather sharp magnetization transition. Magnetization hysteresis loops (MHLs) are also measured, showing a pronounced second peak effect in the intermediate temperature region. The magnetic critical current density calculated from the MHLs at 77 K and 1.5 T is about 6.4 × 104 A cm−2. By using a criterion of 1

%

normal state resistivity, we have determined the irreversibility line which exhibits an irreversibility field of about 8 T at 77 K. Compared with other layered systems, it is easy to find that the irreversibility line is rather high and could be further improved with the optimized transition temperature of about 118 K as previously discovered in polycrystalline samples.
Phase transitions in four-dimensional AdS black holes with a nonlinear electrodynamics source
Authors: Bécar Ramón , González P A , Saavedra Joel , Vásquez Yerko , Wang Bin 
Published: October 2021

Abstract
In this work we consider black hole solutions to Einstein’s theory coupled to a nonlinear power-law electromagnetic field with a fixed exponent value. We study the extended phase space thermodynamics in canonical and grand canonical ensembles, where the varying cosmological constant plays the role of an effective thermodynamic pressure. We examine thermodynamical phase transitions in such black holes and find that both first- and second-order phase transitions can occur in the canonical ensemble while, for the grand canonical ensemble, Hawking–Page and second-order phase transitions are allowed.
Shell evolution in neutron-rich nuclei: the single particle perspective *
Authors: Ma Wei-Qiang , Qian Yi-Bin 
Published: October 2021

Abstract
The isospin dependence of spin-orbit (SO) splitting becomes increasingly important as N/Z increases in neutron-rich nuclei. Following the initial independent-particle strategy toward explaining the occurrence of magic numbers, we systematically investigated the isospin effect on the shell evolution in neutron-rich nuclei within the Woods-Saxon mean-field potential and the SO term. It is found that new magic numbers N = 14 and N =16 may emerge in neutron-rich nuclei if one changes the sign of the isospin-dependent term in the SO coupling, whereas the traditional magic number, N = 20, may disappear. The magic number N = 28 is expected to be destroyed despite the sign choice of the isospin part in the SO splitting, corresponding to the strength of the SO coupling term. Meanwhile, the N = 50 and 82 shells may persist within the single particle scheme, although there is a decreasing trend of their gaps toward extreme proton-deficient nuclei. Besides, an appreciable energy gap appears at N = 32 and 34 in neutron-rich Ca isotopes. All these results are more consistent with those of the interacting shell model when enhancing the strength of the SO potential in the independent particle model. The present study may provide a more reasonable starting point than the existing one for not only the interacting shell model but also other nuclear many-body calculations toward the neutron-dripline of the Segrè chart.
Geopolymerization: a promising technique for membrane synthesis
Authors: Sadiq Muhammad , Naveed Amir , Arif Muhammad , Hassan Saima , Afridi Shaista , Asif Muhammad , Sultana Sabeeh , Amin Noor-ul , Younas Mohammad , Khan Muhammad Naeem , Jiang Heqing , Gul Saeed 
Published: October 2021

Abstract
Ceramic membranes are considered superior over their polymeric counterparts for applications at high temperature, pressure, and in aggressive environments with additional advantages of cleaning at high temperature. Preparation of porous ceramic membrane is expensive because the ceramic materials cannot be processed in a liquid state as polymers. Ceramic membrane synthesis involved solid powder preparation, consolidation, suspension formation, calcination, and sintering temperature which makes its synthesis very expensive. Geopolymerization is a heterogeneous reaction of aluminosilicate materials and chemical activators to form a three-dimensional structure having high mechanical strength without sintering. The overall percent energy and cost-saving of geopolymeric membranes were compared with conventional ceramic membranes. Recently, the geopolymerization technique has been used for membrane synthesis to replace conventional ceramic membrane synthesis. The objective of this review article is to discuss the potential opportunities and challenges in the synthesis and application of geopolymeric membranes.
Linking the Morphology of Sternal Glands to Rubbing Behavior byVespa soror(Hymenoptera: Vespidae) Workers During Recruitment for Group Predation
Authors: Mattila Heather R , Shimano Satoshi , Otis Gard W , Nguyen Lien T P , Maul Erica R , Billen Johan 
Published: October 2021

AbstractThe activities of social insect colonies are supported by exocrine glands and the tremendous functional diversity of the compounds that they secrete. Many social wasps in the subfamilies Vespinae and Polistinae have two sternal glands—the van der Vecht and Richards’ glands—that vary in their features and function across the species in which they are found. Field observations suggest that giant hornets use secretions from the van der Vecht gland to chemically mark targeted nests when workers initiate group attacks on social insect prey. However, descriptions of giant hornets’ sternal glands and details about their recruitment behavior are lacking. We describe the morphology of the sternal glands of the giant hornet Vespa soror du Buysson and consider their potential to contribute to a marking pheromone. We also assess the gastral rubbing behavior of workers as they attacked Apis cerana F. (Hymenoptera: Apidae) colonies. V. soror workers have well-developed van der Vecht and Richards’ glands on their terminal gastral sternites, with morphologies that robustly support the synthesis, storage, and dissemination of their secretory products. Observations confirm that the van der Vecht gland is exposed during gastral rubbing, but that the Richards’ gland and glands associated with the sting apparatus may also contribute to a marking pheromone. Workers briefly but repeatedly rubbed their gasters around hive entrances and on overhead vegetation. Colonies were heavily marked over consecutive attacks. Our findings provide insight into the use of exocrine secretions by giant hornets as they recruit nestmates to prey colonies for group attacks.
Rapid Review of Dermal Penetration and Absorption of Inorganic Lead Compounds for Occupational Risk Assessment
Authors: Niemeier Richard Todd , Maier Andrew , Reichard John F 
Published: October 2021

Abstract
Lead (Pb) exposure continues to be a significant public health issue in both occupational and non-occupational settings. The vast majority of exposure and toxicological studies have focused on effects related to inhalation and gastrointestinal exposure routes. Exposure to inorganic Pb compounds through dermal absorption has been less well studied, perhaps due to the assumption that the dermal pathway is a minor contributor to aggregate exposures to Pb compounds. The aim of this rapid review was to identify and evaluate published literature on dermal exposures to support the estimation of key percutaneous absorption parameters (Kp, flux, diffusion rate) for use in occupational risk assessment. Eleven articles were identified containing information from both in vitro and in vivo systems relevant to percutaneous absorption kinetics. These articles provided 24 individual study summaries and information for seven inorganic Pb compounds. The vast majority of study summaries evaluated (n = 22, 92%) reported detectable amounts of dermal absorption of inorganic Pb. Data were identified for four Pb compounds (Pb acetate, Pb nitrate, Pb oxide, and Pb metal) that may be sufficient to use in evaluating physiologically based pharmacokinetic models. Average calculated diffusion rates for the pool of animal and human skin data ranged from 10−7 to 10−4 mg cm−2 h−1, and Kp values ranged from 10−7 to 10−5 cm h−1. Study design and documentation were highly variable, and only one of the studies identified was conducted using standard test guideline-compliant methodologies. Two studies provided quality estimates on the impacts of dermal absorption from water-insoluble Pb compounds on blood Pb levels. These two studies reported that exposures via dermal routes could elevate blood Pb by over 6 µg dl−1. This estimation could represent over 100% of 5 µg dl−1, the blood Pb associated with adverse health effects in adults. The utility of these estimates to occupational dermal exposures is limited, because the confidence in the estimates is not high. The literature, while of limited quality, overall strongly suggests inorganic Pb has the potential for dermal uptake in meaningful amounts associated with negative health outcomes based on upper bound diffusion rate estimates. Future standard test guideline-compliant studies are needed to provide high-confidence estimates of dermal uptake. Such data are needed to allow for improved evaluation of Pb exposures in an occupational risk assessment context.
Simulated herbivory enhances leaky sex expression in the dioecious herbMercurialis annua
Authors: Villamil Nora , Li Xinji , Seddon Emily , Pannell John R 
Published: October 2021

AbstractBackground and AimsPlant reproductive traits are widely understood to be responsive to the selective pressures exerted by pollinators, but there is also increasing evidence for an important role for antagonists such as herbivores in shaping these traits. Many dioecious species show leaky sex expression, with males and females occasionally producing flowers of the opposite sex. Here, we asked to what extent leakiness in sex expression in Mercurialis annua (Euphorbiaceae) might also be plastically responsive to simulated herbivory. This is important because enhanced leakiness in dioecious populations could lead to a shift in both the mating system and in the conditions for transitions between combined and separate sexes.MethodsWe examined the effect of simulated herbivory on the sexual expression of males and females of M. annua in two experiments in which different levels of simulated herbivory led to enhanced leakiness in both sexes.Key ResultsWe showed that leaky sex expression in both males and females of the wind-pollinated dioecious herb M. annua is enhanced in response to simulated herbivory, increasing the probability for and the degree of leakiness in both sexes. We also found that leakiness was greater in larger females but not in larger males.ConclusionsWe discuss hypotheses for a possible functional link between herbivory and leaky sex expression, and consider what simulated herbivory-induced leakiness might imply for the evolutionary ecology of plant reproductive systems, especially the breakdown of dioecy and the evolution of hermaphroditism.
Artificial intelligence in the prediction of protein–ligand interactions: recent advances and future directions
Authors: Dhakal Ashwin , McKay Cole , Tanner John J , Cheng Jianlin 
Published: October 2021

AbstractNew drug production, from target identification to marketing approval, takes over 12 years and can cost around $2.6 billion. Furthermore, the COVID-19 pandemic has unveiled the urgent need for more powerful computational methods for drug discovery. Here, we review the computational approaches to predicting protein–ligand interactions in the context of drug discovery, focusing on methods using artificial intelligence (AI). We begin with a brief introduction to proteins (targets), ligands (e.g. drugs) and their interactions for nonexperts. Next, we review databases that are commonly used in the domain of protein–ligand interactions. Finally, we survey and analyze the machine learning (ML) approaches implemented to predict protein–ligand binding sites, ligand-binding affinity and binding pose (conformation) including both classical ML algorithms and recent deep learning methods. After exploring the correlation between these three aspects of protein–ligand interaction, it has been proposed that they should be studied in unison. We anticipate that our review will aid exploration and development of more accurate ML-based prediction strategies for studying protein–ligand interactions.
Adding Tree Rings to North America's National Forest Inventories: An Essential Tool to Guide Drawdown of Atmospheric CO2
Authors: Evans Margaret E K , DeRose R Justin , Klesse Stefan , Girardin Martin P , Heilman Kelly A , Alexander M Ross , Arsenault André , Babst Flurin , Bouchard Mathieu , Cahoon Sean M P , Campbell Elizabeth M , Dietze Michael , Duchesne Louis , Frank David C , Giebink Courtney L , Gómez-Guerrero Armando , García Genaro Gutiérrez , Hogg Edward H , Metsaranta Juha , Ols Clémentine , Rayback Shelly A , Reid Anya , Ricker Martin , Schaberg Paul G , Shaw John D , Sullivan Patrick F , GaytÁn Sergio Armando Villela 
Published: October 2021

AbstractTree-ring time series provide long-term, annually resolved information on the growth of trees. When sampled in a systematic context, tree-ring data can be scaled to estimate the forest carbon capture and storage of landscapes, biomes, and—ultimately—the globe. A systematic effort to sample tree rings in national forest inventories would yield unprecedented temporal and spatial resolution of forest carbon dynamics and help resolve key scientific uncertainties, which we highlight in terms of evidence for forest greening (enhanced growth) versus browning (reduced growth, increased mortality). We describe jump-starting a tree-ring collection across the continent of North America, given the commitments of Canada, the United States, and Mexico to visit forest inventory plots, along with existing legacy collections. Failing to do so would be a missed opportunity to help chart an evidence-based path toward meeting national commitments to reduce net greenhouse gas emissions, urgently needed for climate stabilization and repair.
Machine learning for the life-time risk prediction of Alzheimer’s disease: a systematic review
Authors: Rowe Thomas W , Katzourou Ioanna K , Stevenson-Hoare Joshua O , Bracher-Smith Matthew R , Ivanov Dobril K , Escott-Price Valentina 
Published: October 2021

Abstract
Alzheimer’s disease is a neurodegenerative disorder and the most common form of dementia. Early diagnosis may assist interventions to delay onset and reduce the progression rate of the disease. We systematically reviewed the use of machine learning algorithms for predicting Alzheimer’s disease using single nucleotide polymorphisms and instances where these were combined with other types of data. We evaluated the ability of machine learning models to distinguish between controls and cases, while also assessing their implementation and potential biases. Articles published between December 2009 and June 2020 were collected using Scopus, PubMed and Google Scholar. These were systematically screened for inclusion leading to a final set of 12 publications. Eighty-five per cent of the included studies used the Alzheimer's Disease Neuroimaging Initiative dataset. In studies which reported area under the curve, discrimination varied (0.49–0.97). However, more than half of the included manuscripts used other forms of measurement, such as accuracy, sensitivity and specificity. Model calibration statistics were also found to be reported inconsistently across all studies. The most frequent limitation in the assessed studies was sample size, with the total number of participants often numbering less than a thousand, whilst the number of predictors usually ran into the many thousands. In addition, key steps in model implementation and validation were often not performed or unreported, making it difficult to assess the capability of machine learning models.
Cross-task adaptation effects of bilingual language control on cognitive control: a dual-brain eeg examination of simultaneous production and comprehension
Authors: Liu Huanhuan , Li Wanqing , Zuo Mingyue , Wang Fenqi , Guo Zibin , Schwieter John W 
Published: October 2021

AbstractFor bilinguals, speaking and listening are assisted by complex control processes including conflict monitoring and inhibition. However, the extent to which these processes adapt to linguistic and situational needs has been examined separately for language production and comprehension. In the present study, we use a dual-EEG to record the carry-over effects of language control on general cognitive control in three language contexts (single-first language [L1], single-second language [L2], and mixed). Chinese learners of English were placed in dyads in which one participant was asked to name pictures while the other listened. Interleaved after each naming/listening trial were flanker trials. The results from picture naming and listening revealed higher delta and theta synchronization in the single-L2 and mixed contexts compared with the single-L1 context and higher theta synchronization in the mixed context compared with the single-L2 and single-L1 contexts. The results from the interleaved flanker trials demonstrated that inhibition was adaptively generalized in the single-L2 and mixed contexts. Altogether, the findings support the natural adaptation of language control to cognitive control and underscore the importance of linguistic context. We argue that these adaptive patterns have the potential to affect corresponding control processes across language and cognitive control tasks.
Evidence of Brain Alterations in Noncerebral Falciparum Malaria
Authors: Mohanty Sanjib , Sahu Praveen K , Pattnaik Rajyabardhan , Majhi Megharay , Maharana Sameer , Bage Jabamani , Mohanty Akshaya , Mohanty Anita , Bendszus Martin , Patterson Catriona , Gupta Himanshu , Dondorp Arjen M , Pirpamer Lukas , Hoffmann Angelika , Wassmer Samuel C 
Published: October 2021

Abstract

Background
Cerebral malaria in adults is associated with brain hypoxic changes on magnetic resonance (MR) images and has a high fatality rate. Findings of neuroimaging studies suggest that brain involvement also occurs in patients with uncomplicated malaria (UM) or severe noncerebral malaria (SNCM) without coma, but such features were never rigorously characterized.

Methods
Twenty patients with UM and 21 with SNCM underwent MR imaging on admission and 44–72 hours later, as well as plasma analysis. Apparent diffusion coefficient (ADC) maps were generated, with values from 5 healthy individuals serving as controls.

Results
Patients with SNCM had a wide spectrum of cerebral ADC values, including both decreased and increased values compared with controls. Patients with low ADC values, indicating cytotoxic edema, showed hypoxic patterns similar to cerebral malaria despite the absence of deep coma. Conversely, high ADC values, indicative of mild vasogenic edema, were observed in both patients with SNCM and patients with UM. Brain involvement was confirmed by elevated circulating levels of S100B. Creatinine was negatively correlated with ADC in SNCM, suggesting an association between acute kidney injury and cytotoxic brain changes.

Conclusions
Brain involvement is common in adults with SNCM and a subgroup of hospitalized patients with UM, which warrants closer neurological follow-up. Increased creatinine in SNCM may render the brain more susceptible to cytotoxic edema.
Successful treatment of calciphylaxis with vitamin K in a patient on haemodialysis
Authors: Wajih Zainab , Singer Richard 
Published: October 2021

Abstract
Calciphylaxis has high mortality. Vitamin K deficiency is common in haemodialysis patients and may be a trigger for calciphylaxis due to its role in activating a tissue inhibitor of calcification, matrix Gla protein. We report a second case of a female haemodialysis patient who developed calciphylaxis twice and was successfully treated with vitamin K supplementation on both occasions. She did not receive sodium thiosulphate or bisphosphonates nor was there a change made to her dialysis time or prescription. This case highlights how supplementation with vitamin K may improve the outcome of this condition.