bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fractal analysis of 11C-methionine PET in patients with newly diagnosed glioma
Authors: Maeda Yukito , Yamamoto Yuka , Norikane Takashi , Mitamura Katsuya , Hatakeyama Tetsuhiro , Miyake Keisuke , Nishiyama Yoshihiro , Kudomi Nobuyuki 
Published: November 2021

Abstract
Background
The present study tested the possible utility of fractal analysis from l-[methyl-11C]-methionine (MET) uptake in patients with newly diagnosed gliomas for differentiating glioma, especially in relation to isocitrate dehydrogenase 1 (IDH1) mutation status, and as compared with the conventional standardized uptake value (SUV) parameters.

Methods
Investigations of MET PET/CT were performed retrospectively in 47 patients with newly diagnosed glioma. Tumors were divided into three groups: lower grade glioma (IDH1-mutant diffuse astrocytoma and IDH1-mutant anaplastic astrocytoma), higher grade glioma (IDH1-wildtype diffuse astrocytoma and IDH1-wildtype anaplastic astrocytoma), and glioblastoma. The fractal dimension for tumor, maximum SUV (SUVmax) for tumor (T) and mean SUV for normal contralateral hemisphere (N) were calculated, and the tumor-to-normal (T/N) ratio was determined. Metabolic tumor volume (MTV) and total lesion MET uptake (TLMU) were also measured.

Results
There were significant differences in SUVmax (p = 0.006) and T/N ratio (p = 0.02) between lower grade glioma and glioblastoma. There were no significant differences among any of the three groups in MTV or TLMU. Significant differences were obtained in the fractal dimension between lower grade glioma and higher grade glioma (p = 0.006) and glioblastoma (p < 0.001).

Conclusions
The results of this preliminary study in a small patient population suggest that the fractal dimension using MET PET in patients with newly diagnosed gliomas is useful for differentiating glioma, especially in relation to IDH1 mutation status, which has not been possible with SUV parameters.
Attention to social stratification in the public discourse: An empirical study based on big data of books (1949–2008)
Authors: Liu Jiankun , Chen Yunsong 
Published: November 2021

AbstractUsing the Chinese corpus of Google Books Ngram in line with other macro-level socioeconomic data, this paper examines and analyzes the trend of change in public discourse about social structure in China from 1949 to 2008, as well as the mechanism that influences this trend. We find that since the reform and opening-up, the official discourse on “class,” as constructed by the official ideology, has gradually declined, while the importance of a “stratum” discourse oriented toward the mass population has increased. Using principal component analysis, we generate an index for public attention on social strata and run it through a Granger causality test along with time-series data such as macro-level economic and political indicators. The results show that since the reform and opening-up, public attention to stratum has been influenced by the general trend of the economy, income disparity, and level of political participation. Income disparity influences public attention on stratum-related topics more than macro-level economic indicators do. Official intervention on public opinions does not affect public attention on the stratum, but the former is affected by the latter.
Associations between ADIPOQ rs2241766 SNP and breast cancer risk: a systematic review and a meta-analysis
Authors: Hu Xue , Cui Chunguo , Sun Tong , Wang Wan 
Published: November 2021

Abstract
Purpose
We aimed to conduct a meta-analysis to accurately evaluate the potential association between ADIPOQ rs2241766 gene SNP and breast cancer risk.

Methods
A systematic literature search on Cochrane Library, PubMed, Embase, Web of Science and China National Knowledge Infrastructure (CNKI) identified 8 articles with 1692 cases and 1890 controls. Strength of association was evaluated by pooled odds ratio (OR), 95 % confidence interval (CI) and p value. Funnel plots and Begger’s regression test were applied for testing the publication bias. Statistical analysis of all data was performed by Stata 12.0.

Results
The meta-analysis results indicated that the ADIPOQ rs2241766 gene polymorphism did not significantly associated with the risk of breast cancer for these genetic models (TT vs. TG + GG: OR = 1.20, 95 % CI = 0.77–1.89, p=0.417; TT + TG vs. GG: OR = 1.05, 95 % CI = 0.71–1.56, p=0.805; T vs. G: OR =1.17, 95 % CI = 0.79–1.74, p=0.437).

Conclusions
This study indicated that no significant relationship between the ADIPOQ rs2241766 SNP and breast cancer. Further large-scale and well-designed studies will be indispensable to confirm our result.
Recognizing duration effects in multistate population models
Authors: Schoen Robert 
Published: November 2021

AbstractThe risk of many demographic events varies by both current state and duration in that state. However, the use of such semi-Markov models has been substantially constrained by data limitations. Here, a new specification of the semi-Markov transition probability matrix in terms of the underlying rates is provided, and a general procedure is developed to estimate semi-Markov probabilities and rates from adjacent population data.Multistate models recognizing marriage and divorce by duration in state are constructed for United States Females, 1995. The results show that recognizing duration in the married and divorced states adds significantly to the model’s analytical value. Extending the constant-α method to semi-Markov models, 2000–2005 U.S. population data and 1995 cross-product ratios are employed to estimate 2000–2005 duration-dependent transfer probabilities and rates.The present analyses provide new relationships between probabilities and rates in semi-Markov models. Extending the constant cross-product ratio estimation approach opens new sources of data and expands the range of data susceptible to state-duration analyses.
Development and equivalence of new faces for inclusion in the Childhood Asthma Control Test (C-ACT) response scale
Authors: Sully Kate , Bonner Nicola , Bradley Helena , von Maltzahn Robyn , Arbuckle Rob , Walker-Nthenda Louise , Mahon Aoife , Becker Brandon , O’Hara Louise , Bevans Katherine B. , Kosinski Mark , Zeiger Robert S. , Mackenzie Ross , Nelsen Linda 
Published: November 2021

Abstract
Background
Accurate symptom monitoring is vital when managing pediatric asthma, providing an opportunity to improve control and relieve associated burden. The CHILDHOOD ASTHMA CONTROL TEST (C-ACT) has been validated for asthma control assessment in children; however, there are concerns that response option images used in the C-ACT are not culturally universal and could be misinterpreted. This cross-sectional, qualitative study developed and evaluated alternative response option images using interviews with children with asthma aged 4–11 years (and their parents/caregivers) in the United States, Spain, Poland, and Argentina. Interviews were conducted in two stages (with expert input) to evaluate the appropriateness, understanding and qualitative equivalence of the alternative images (both on paper and electronically). This included comparing the new images with the original C-ACT response scale, to provide context for equivalence results.

Results
Alternative response option images included scale A (simple faces), scale B (circles of decreasing size), and scale C (squares of decreasing quantity). In Stage 1, most children logically ranked images using scales A, B and C (66.7%, 79.0% and 70.6%, respectively). However, some children ranked the images in scales B (26.7%) and C (58.3%) in reverse order. Slightly more children could interpret the images within the context of their asthma in scale B (68.4%) than A (55.6%) and C (47.5%). Based on Stage 1 results, experts recommended scales A (with slight modifications) and B be investigated further. In Stage 2, similar proportions of children logically ranked the images used in modified scales A (69.7%) and B (75.7%). However, a majority of children ranked the images in scale B in the reverse order (60.0%). Slightly more children were able to interpret the images in the context of their asthma using scale B (57.6%) than modified scale A (48.5%). Children and parents/caregivers preferred modified scale A over scale B (78.8% and 90.9%, respectively). Compared with the original C-ACT, most children selected the same response option on items using both scales, supporting equivalency. Following review of Stage 2 results, all five experts agreed modified scale A was the optimal response scale.

Conclusions
This study developed alternative response option images for use in the C-ACT and provides qualitative evidence of the equivalency of these response options to the originals.
Dexmedetomidine versus fentanyl in intraoperative neuromuscular monitoring using propofol based total intravenous anesthesia regimen in kyphoscoliosis correction surgery
Authors: Panse Neha Amey , Kale Jyoti Vishnu , Phalke Tejaswini Lalasaheb , Bhojane Utkarsha Pradeep 
Published: November 2021

AbstractBackgroundIntraoperative neuromuscular monitoring (IONM) is used to reduce the risk of postoperative neurological deficit in patients undergoing kyphoscoliosis correction surgery. Somatosensory evoked potentials (SSEPs) are among the several techniques developed by neurophysiologists to increase the sensitivity of intraoperative monitoring. We administered total intravenous anesthesia (TIVA) to 20 patients undergoing kyphoscoliosis deformity correction surgeries: group A: propofol and dexmedetomidine and group B: propofol and fentanyl. The primary objective of our study was to compare the effect of dexmedetomidine and fentanyl on intraoperative hemodynamic parameters and their interference with SSEP’s readings. The secondary objective was to assess the total intraoperative requirement of inhalational anesthetic agents, quality of surgical field, and the cost-effectiveness of either regimen.ResultsIntraoperative hemodynamic stability, analgesia, surgical field, and cost-effectiveness (due to reduced requirement of sevoflurane) were better with dexmedetomidine than fentanyl. SSEPs were successfully recorded with both the drugs while the requirement of inhalation anesthetic agents was significantly reduced in the dexmedetomidine group than in the fentanyl group. There were no injuries while recording SSEPs. The latency and amplitude of SSEPs were maintained throughout either group. No intraoperative awakening or awareness was noted (bispectral index was maintained in the range of 40 to 60). No postoperative neurological deficit was noted in any patient.ConclusionsBoth dexmedetomidine and fentanyl can be successfully used in propofol-based TIVA for SSEP monitoring in kyphoscoliosis correction surgeries, but the better analgesic profile, ease of maintaining stable hemodynamics with a significant reduction in inhalational agent requirement, and opioid-sparing effect by dexmedetomidine make it a more desirable agent to be used in propofol-based TIVA.
The impact of a low-calorie, low-glycemic diet on systemic lupus erythematosus: a systematic review
Authors: Imoto Aline Mizusaki , Gottems Leila Bernarda , Salomon Ana Lúcia , Silva Helbert Eustáquio Cardoso e , Júnior Império Lombardi , Peccin Maria Stella , Amorim Fábio Ferreira , Santana Levy Aniceto 
Published: November 2021

Abstract
Background
Diet plays a critical role in Systemic Lupus Erythematosus (SLE) patients, impacting on the microbiota composition and, consequently, on the immune response. The objective was to analyze and verify the diet effect on SLE patients.

Methods
This is a systematic review performed at the Evidences-based Health Lab, Escola Superior em Ciências da Saúde, Brasília (DF), Brazil. In March, 2021, five databases, and grey literature, through JSTOR, Open Grey, and Google Scholar were searched. Randomized Clinical Trials in which SLE patients with calorie restricted, low glycemic index or other diet involving the joint adequacy of these aspects, compared with placebo or different types of diet, were included.

Results
It was identified in the databases 758 articles; 132 were duplicated; 616 references were screened, and 604 were excluded. After reading the title and abstract, 12 articles were included for full-text reading. After the full-text reading, three studies were included for quantitative analysis. The diet improved the quality of life at 6 (MD 16.30; 5.91;26.69) and 12 weeks (MD 14.60; 0.88;28.32). The GRADE was used to evaluate the quality of evidence.

Conclusion
There is low evidence that the diet has a positive impact on the quality of life of SLE patients.
Trial registration PROSPERO—CRD4202012208.
Mobile health interventions for HIV/STI prevention among youth in low- and middle-income countries (LMICs): a systematic review of studies reporting implementation outcomes
Authors: Nwaozuru Ucheoma , Obiezu-Umeh Chisom , Shato Thembekile , Uzoaru Florida , Mason Stacey , Carter Victoria , Manu Sunita , Modi Karan , Parker Jessica , Ezechi Oliver , Iwelunmor Juliet 
Published: November 2021

Abstract
Background
Advances and proliferation of technologies such as mobile phones may provide opportunities to improve access to HIV/STI services and reach young people with high risk for HIV and STI. However, the reach, uptake, and sustainability of mobile health (mHealth) HIV/STI interventions targeting young people aged 10–24 years in low- and middle-income countries (LMICs) are largely unknown. To address this gap and to inform implementation science research, a review was conducted to summarize what is known, and what we need to know about implementing mhealth interventions for HIV/STI prevention targeting young people in LMICs.

Methods
We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for this review. Drawing upon Proctor’s eight implementation outcome measures, we evaluated the acceptability, adoption, appropriateness, cost, feasibility, fidelity, penetration, and sustainability of m-health HIV/STI interventions targeting young people in LMICs. The search was performed from September 2020–January 2021 and updated on March 1, 2021, in Cumulative Index to Nursing and Allied Health Literature (CINAHL), PubMed, SCOPUS, Global Health, and Web of Science. Eligible studies were required to include an HIV/STI prevention outcome, target young people aged 10–24 years, include a comparison/control group, and reporting of atleast one implementation outcome as outlined by Proctor.

Results
A total of 1386 articles were located, and their titles and abstracts were screened. Of these, 57 full-text articles were reviewed and subsequently, and 11 articles representing 6 unique interventions were included in the systematic review. Acceptability 6 (100%), appropriateness 6 (100%), and feasibility 5(83%) were the most frequently evaluated implementation outcomes. Adoption 2 (33%), fidelity 1 (17%), and cost 1 (17%) were rarely reported; penetration and sustainability were not reported.

Conclusions
This review contributes to implementation science literature by synthesizing key implementation outcomes of mHealth HIV/STI interventions targeting young people in LMICs. Future research is needed on m-health HIV/STI implementation outcomes, particularly the penetration, cost, and long-term sustainability of these interventions. Doing so will enhance the field’s understanding of the mechanisms by which these interventions lead or do not lead to changes in high HIV/STI risk and vulnerability among young people in LMICs.
Investigation of flexible pavement maintenance patching factors using a finite element model
Authors: Lu Yujia , Hajj Ramez 
Published: November 2021

AbstractPatching of flexible pavements is one of the most important functions of pavement maintenance. Although finite element modeling has become commonplace in the world of pavement engineering, modeling has not yet been significantly leveraged for maintenance applications which improve safety, ride quality, and pavement service life. The objective of this study was to model viscoelastic properties of pavement and patching materials to determine the effect of various repair factors on pavement performance using the finite element method. Specifically, surface permanent deformation, local shear stress concentration, and horizontal strain distribution were investigated. Two types of models were simulated; the first model applied static loading to a surface layer fixed on a plate and the second model applied cyclic traffic loading to a two-layered flexible pavement system. The results demonstrate the importance of patching using a semi-permanent method. The results also demonstrated the accumulated effect of repeated loading using a time-dependent material response. Results also indicated that a larger patching area resulted in less influence of the shape of the area, while a circular area proved superior to a conventional rectangular patch for sizes near the tire footprint and smaller than it. Different responses were observed depending on the type of patching material modeled, demonstrating the effect of material choice in maintenance applications. Finally, mesh optimization was performed to ensure appropriate mesh sizes are used in future studies to accurately represent the pavement layers and patches.
The detection of earnings management through a decrease of corporate income tax
Authors: Wali Kawa 
Published: November 2021

AbstractThis paper explores the manner in which Dutch and German listed companies were able to manage earnings by the decline in corporate income tax toward the end of the 2000s. In addition, a recent article examines the existing state of earnings management at a European level in the Netherlands and Germany. This empirical study sampled 1350 firm-years for the Netherlands and 1850 firm-years for Germany between 2000 and 2018. The study indicated that those firms with larger prospect tax savings appeared to exercise earnings management to hasten discretionary accruals. In view of the income-reducing impact these discretionary deductions have on financial statements, the findings show corporate income taxes are a significant incentive. Since companies can reduce tax costs by deferring income tax to a subsequent year and lower the tax tariff cycle, theoretically, this tax reform incentivizes management to manage their earnings with the purpose of minimize tax payments. More research is needed into the impact of tax compliance on declining earnings management in this area.
Method development and validation for Cabotegravir and Rilpivirine by using HPLC and its degradants are characterized by LCMS and FTIR
Authors: Vejendla Anuradha , Talari Subrahmanyam , Moturu Raju , Boddapati S. N. Murthy , Kola A. Emmanuel 
Published: November 2021

Abstract
Background
Using a Symmetry C18 (4.6 × 150 mm, 3.5) column, a high-performance liquid chromatographic method for quantification of Rilpivirine and Cabotegravir in active pharmaceutical ingredients was developed and validated. The mobile phase is made up of buffer, acetonitrile, and 0.1 percent formic acid in a 20:80v/v ratio. The flow rate was kept constant at 1.0 ml/min, and detection was accomplished through absorption at 231 nm with a photodiode array detector.

Results
The calibration curve was linear, with a regression coefficient (R2) value of 0.999 and concentrations ranging from 30 to 450 g/ml of Rilpivirine and 20–300 g/ml of Cabotegravir. The method's LOD and LOQ were 0.375 g/ml, 1.238 g/ml, and 0.25 g/ml, 0.825 g/ml for Rilpivirine and Cabotegravir, respectively.

Conclusions
In the forced degradation studies, the degradants were characterized by using LCMS and FTIR. The current application was found to be simple, economical, and suitable, and validated according to ICH guidelines.
The incidence of dysgraphia in Arabic language in children with attention-deficit hyperactivity disorder
Authors: Lotfy Amira Salah , Darwish Mohammed El Sayed , Ramadan Ehab Sayed , Sidhom Rania Makram 
Published: November 2021

Abstract
Background
Attention-deficit/hyperactivity disorder (ADHD) is a brain disorder marked by an ongoing pattern of inattention and/or hyperactivity-impulsivity that interferes with functioning or development. Although children with ADHD made much more spelling errors, they had a distinct pattern of letter insertions, replacements, transpositions, and omissions. This mistake type is sometimes referred to as graphemic buffer errors, and it is caused by a lack of attention required for motor planning. The aim of study was to assess the incidence of dysgraphia in Arabic language in children with ADHD for better helping, diagnosis and management of those children.

Results
Ten percent of ADHD children had normal handwriting with no disability, 40% had excellent handwriting with a minimum of disability and 50% of ADHD children showed mild to moderate disability. There were significant differences between ADHD children and control children regarding results of each item on the subtest of handwriting of dysgraphia disability scale (DDS), respecting lines, spacing between words, letter direction, spelling a sentence, and punctuation. Drawing affected in ADHD children. The finger tapping speed was affected in almost ADHD children.

Conclusions
Dysgraphia highly presents in our sample of ADHD children with poor fine motor skills in ADHD children than normal children. ADHD children have illegible handwriting, not respecting lines, insufficient space between and within words, multiple spelling errors, and omissions of letters or words. Graphesthesia and stereognosis are affected more in ADHD children than in control children drawing and finger tapping speed affected in ADHD children.
Weight Change, Lifestyle, and Mortality in Patients With Type 2 Diabetes
Authors: Hu Jinbo , Hu Yang , Hertzmark Ellen , Yuan Chen , Liu Gang , Stampfer Meir J , Rimm Eric B , Hu Frank B , Wang Molin , Sun Qi 
Published: November 2021

Abstract

Context
The association between weight change and mortality among participants with incident type 2 diabetes (T2D) was unclear.

Objective
To examine above association and evaluate the impact of lifestyle on it.

Methods
This prospective analysis included 11 262 incident T2D patients from Nurses’ Health Study and Health Professionals Follow-up Study. We assessed weight change bracketing T2D diagnosis in relation to mortality. We also examined potential effect modification by a healthy lifestyle consisting of high-quality diet, regular physical activity, nonsmoking status, and moderate alcohol consumption.

Results
On average, T2D patients lost 2.3 kg during a 2-year time window spanning the T2D diagnosis, and body weight increased afterwards following a trajectory similar to that of nondiabetics. Compared with patients with a stable weight, T2D patients who lost ≥10% body weight had a 21% (95% CI, 9%-35%) increased all-cause mortality. Lifestyle significantly modified these associations: the hazard ratios (95% CIs) of all-cause mortality comparing ≥10% weight loss with stable weight were 1.63 (1.26-2.09) among participants with a deteriorated lifestyle, 1.27 (1.11-1.46) for a stable lifestyle, and 1.02 (0.81-1.27) for an improved lifestyle (Pinteraction &lt; 0.001). Major weight loss was associated with increased cause-specific mortality and similar effect modifications by lifestyle were also observed.

Conclusion
Significant weight loss upon T2D incidence was associated with increased mortality, although improved lifestyle quality abolished these associations. These results highlight the role of adopting a healthy lifestyle for newly diagnosed T2D patients, especially among those who might lose weight unintentionally, and improving long-term survival.