bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modularity of total hip prosthesis and its tribological implications
Authors: Badita Liliana-Laura , Florescu Virgil , Tiganesteanu Constantin , Capitanu Lucian 
Published: November 2021

Purpose
The study aims to analyze the fretting phenomenon, manifested at the taper junctions of modular total hip prostheses (THP). Modularity of prostheses implies the micro-movement occurrence. Fractures can arise as a result of the fretting cracking of the prostheses components, affecting durability of modular THPs. Fretting corrosion is associated with the decrease in the clinical acceptance of hip modular implants.

Design/methodology/approach
Starting from the fretting phenomenon influence on modularity, monoblock THPs and prostheses with modular femoral head recovered from some review surgeries were investigated. Modular prostheses have a taper junction femoral head – femoral stem neck. Investigation consisted in the analysis of fretting wear and fretting corrosion, of the femoral heads’ taper and of the femoral stems’ trunnions.

Findings
The main result was that the micro-movement that provokes the fretting of the femoral head-femoral stem taper junction analyzed does not have the same direction. It is manifesting in the direction of the axis of the femoral head taper, around this axis or as a composed movement. The authors suspect that this is due to the different design of the taper. In this way, the inclination of the stem’s trunnion into the head hole has a different angular misalignment and may cause greater damages of the taper.

Originality/value
This result can be a starting point from the improvement of the future taper junctions design that will improve the quality, durability and modularity of THPs.
Effect of quality of governance on the relationship between illicit financial flows and economic growth
Authors: Mohd Padil Hazlina , Kasim Eley Suzana , Mohd Razali Fazlida , Atan Ruhaya , Aminullah Haziq 
Published: November 2021

Purpose
The purpose of this paper is twofold. First, the study aims to examine the direct effect of illicit financial flows (IFF) and quality of governance (QoG) on economic growth. Second, this study seeks to examine the moderating effect of QoG on the economic consequences of IFF.

Design/methodology/approach
This study collected data from nine The Association of Southeast Asian Nations (ASEAN) countries for the period of 10 years from 2008 to 2019. The study concerned an analysis of the testing of a conceptual framework which based on secondary data which may lack a comprehensive substantiation on the grounds of measurement theory. A partial least squares (PLS) modelling using the SmartPLS 3.2.8 version was used as a statistical tool to examine the measurement and structural model.

Findings
Key findings provide empirical support on the effect of IFF and QoG on economic growth. It also confirmed that QoG significantly moderated the relationship between IFF and economic growth by reducing the negative impact of IFF on economic growth.

Practical implications
Immediate corrective action needs to be implemented by policymakers of ASEAN countries to strengthen QoG to effectively curb IFF activities.

Originality/value
This study provides current empirical evidence on the relationship of IFF, QoG and economic growth within ASEAN countries.
Corporate social responsibility as a legitimation strategy in a merger
Authors: Thelisson Anne-Sophie , Meier Olivier 
Published: November 2021

PurposeThe objective of the study is to explore legitimation dynamics in a public–private integration process and to gain insights on the specific role of CSR in triggering public–private logics.Design/methodology/approachCorporate social responsibility (CSR) is part of firms' strategy in gaining legitimacy from their stakeholders in a merger context. However, little is known about the role of CSR in triggering diverse dynamics from public or private logics during post-merger integration. This study aims at exploring the specific role of CSR in triggering such diverse logics. A qualitative research design based on a single case study of a public–private merger of two French listed companies in the urban planning sector was opted for. The analysis was pursued in real time from the signing of the agreement and then over two years.FindingsThe results show that public–private legitimation is a process that proceeds in stages. The authors emphasize the key factors that characterize it: align on external concerns: reflecting societal and institutional pressures (public legitimation); readapt to make sense internally in relation to the merger through managerial innovation (private legitimation) and CSR as a form of corporate self-storying: combining the social and societal aspects of CSR within the organization (hybrid legitimation). Three major actions were identified in activating a CSR legitimation strategy: identifying and responding to local needs; building a unified brand, culture, and employee commitment to the organization; and creating sustainable programs.Research limitations/implicationsThe first major contribution is linked to triggers influencing legitimation dynamics and in particular the role of CSR operating as a legitimation strategy in the merger integration process. A second theoretical contribution is linked to the evolutionary nature of the post-merger integration process. The processual study shows how stakeholder legitimacy demands can escalate and change over time.Practical implicationsFirst, three major actions were identified as key steps in activating a CSR legitimation strategy (identifying and responding to local needs; building a unified brand, culture, and employee commitment to the organization; and creating sustainable programs). These missions can be understood as key steps for managers in implementing CSR within an organization in a post-merger integration context. Second, this study increases our comprehension of legitimation as a dynamic micro-process. The different stages described in the study can be considered by the managers involved in the merger process as learning experiences to understand the complex phenomenon that is the integration process.Originality/valueThis study enriches the legitimacy-as-process perspective in providing insights on the specific role of CSR in triggering public–private logics.
Cloud computing and ERP assimilation in the public sector: institutional perspectives
Authors: Alsharari Nizar Mohammad 
Published: November 2021

PurposeThis study aims to explore the influence of contingent factors on the assimilation of the cloud enterprises resources plan (ERP) system in the UAE’s public sector. It explains the relationship between institutional logics and institutional work while implementing ERP-based cloud computing (CC) to transform the government.Design/methodology/approachThis study uses qualitative methods and an interpretive approach to provide an in-depth explanation for a detailed case study in the public sector. The institutional logics framework has been used to inform the integration between ERP system and CC in the public sector case.FindingsFindings show that the UAE public sector could align institutional work processes with the inbuilt logics of ERP-based CC, resulting in successful assimilation of the cloud version. This study concludes that institutional pressures in highly institutionalized environments will generate organizational responses, but those responses are dependent upon and influenced by aspects of organizational culture. This study found that the organizational culture has led to a radical change by implementing the cloud ERP system and institutionalizing its usage toward transforming government. Moreover, ERP assimilation is the extent to which an organization has developed from understanding the ERP system’s functionalities to mastering and deploying them in their processes.Research limitations/implicationsThis study has important implications and contributions to the literature in three ways. First, this study examines an understudied topic, the interaction between CC and institutional logics. Second, this study contributes to the public sector research by providing a fine-tuned interpretation of the organization’s strategic behavior in response to a new information technology (IT) trend. Finally, this study also focuses on this new trend of CC which can influence the global IT industry, and it is worthy of being considered.Originality/valueExplanatory case study research has a value to the public sector that one might be discovering new phenomena while analyzing the public sector case. The implementation of cloud ERP is one of the best methods of integrating technology with the public sector’s organizational, technical, economic, social, cultural and other environmental domains.
What's in a Name? The Length of Westminster Constituency Titles, 1950–2024
Authors: Cowley Philip , Bailey Matthew 
Published: November 2021

AbstractParliamentary constituencies in the UK are named after the areas they cover. Over the last seventy years, the titles given to these constituencies have been getting longer and more cumbersome. They are now less likely to consist of single words and are more likely to be compounds of multiple places. The article demonstrates these changes, including the differences across the constituent nations of the UK, and discusses the possible reasons for the changes. The boundary changes proposed for the next election would result in the longest and most cumbersome constituency names since Britain first began with single‐member, one person, one vote constituencies in 1950.
Caesarean birth in women with infertility: population‐based cohort study
Authors: Richmond E , Ray JG , Pudwell J , Djerboua M , Gaudet L , Walker M , Smith GN , Velez MP 
Published: November 2021

ObjectiveCaesarean section (CS) is more common following infertility treatment (IT) but the reasons why remain unclear and confounded. The Robson 10‐Group Classification System (TGCS) may further explain variation in CS rates. We assessed the association between mode of conception and CS across Robson groups.DesignPopulation‐based cohort study.SettingOntario, Canada, in a public healthcare system.Population921 023 births, 2006–2014.MethodsModified Poisson regression produced relative risks (RR) and 95% confidence intervals, comparing the risk of CS among women with (1) subfertility without IT, (2) non‐invasive IT (OI, IUI) or (3) invasive IT (IVF)—each relative to (4) spontaneous conception (SC).Main outcome measuresCS rate according to one of four modes of conception, overall and stratified by each of the TGCS groups.ResultsRelative to SC (26.9%), the risk of CS increased in those with subfertility without IT (RR 1.17, 95% CI 1.16–1.18), non‐invasive IT (RR 1.21, 95% CI 1.18–1.24) and invasive IT (RR 1.39, 95% CI 1.36–1.42). Within each Robson group, similar patterns of RRs were seen, but with markedly differing rates. For example, in Group 1 (nulliparous, singleton, cephalic at ≥37 weeks, with spontaneous labour), the respective rates were 15.0, 19.4, 18.7 and 21.9%; in Group 2 (nulliparous, singleton, cephalic at ≥37 weeks, without spontaneous labour), the rates were 35.9, 44.4, 43.2 and 54.1%; and in Group 8 (multiple pregnancy), they were 55.9, 67.5, 65.0 and 69.3%, respectively.ConclusionsCS is relatively more common in women with subfertility and those receiving IT, an effect that persists across Robson groups.Tweetable abstractCaesarean delivery is more common in women with infertility independent of demographics and prenatal conditions.
Untargeted lipidomics analysis in women with intrahepatic cholestasis of pregnancy: a cross‐sectional study
Authors: Sun X , Qu T , Wang W , Li C , Yang X , He X , Wang Y , Xing G , Xu X , Yang L , Zhang H 
Published: November 2021

ObjectiveTo compare the plasma lipid profiles in women with normal pregnancies and those with mild or severe intrahepatic cholestasis of pregnancy (ICP). Our goal was to reveal lipidome‐wide alterations in ICP and delve into the pathogenesis of ICP from a lipid metabolism perspective.DesignCross‐sectional study, including women with normal pregnancies, women with mild ICP and women with severe ICP.SettingGansu Provincial Hospital.PopulationWomen with ICP were recruited from October 2019 to March 2020 in Gansu, China.MethodsUntargeted lipidomics was used to analyse differentially expressed plasma lipids in controls, in women with mild ICP and in women with severe ICP (n = 30 per group). For lipidomics, liquid chromatography and Q‐Exactive Plus Orbitrap mass spectrometry were performed.Main outcome measuresDifferentially expressed lipids.ResultsThirty‐three lipids were differentially expressed in the severe and mild ICP groups, compared with the control group, and 20 of those were sphingolipids (ceramide, six species; sphingomyelin, 14 species). All differentially expressed sphingolipids in women with mild ICP were also differentially expressed in women with severe ICP; the fold change and significance of the differential expression were positively correlated with disease severity.ConclusionsWe systematically characterized the lipidome‐wide alterations in mild and severe ICP groups. The results indicated a link between ICP and disordered sphingolipid homeostasis.Tweetable abstractAbnormal sphingolipid metabolism is involved in the pathogenesis of ICP.
Dielectric properties of calamansi (Citrus microcarpa) under high‐temperature treatment
Authors: Yu Zhongliang , Li Lili , Wang Zhizhong 
Published: November 2021

AbstractHigh‐temperature treatment of fruit is a developing way of decreasing nutrient loss and preventing decay. Its effect on calamansi (Citrus microcarpa) has not yet been reported. This study aims to study the effects of high‐temperature treatment via dielectric properties. The results show that high‐temperature treatment of calamansi suppresses the dielectric constant between 200 MHz and 20 GHz and alters loss factor between 200 MHz and 10 GHz. Storage at room temperature can affect loss factor between 4.5 and 10 GHz. These results may indicate that the dehydration process first affects the loss factor from 4.5 to 10 GHz, and then from 200 MHz to 4.5 GHz. This study may be favorable for evaluating calamansi's quality during storage and transportation. Moreover, the loss factor under 10 GHz is promising as an index for monitoring the water deficit and for assessing the adopted pre‐treatment on calamansi.Practical ApplicationThe quality inspector can use nondestructive examination ways to measure the dielectric property for evaluating Citrus microcarpa’s quality and storage time after harvest. Moreover, the adopted pre‐treatment may be speculated.
Multiplying the heterologous production of spinosad through tandem amplification of its biosynthetic gene cluster in Streptomyces coelicolor
Authors: Li Hong , Pan Yuanyuan , Liu Gang 
Published: November 2021

SummaryHeterologous expression of the biosynthetic gene cluster (BGC) is important for studying the microbial natural products (NPs), especially for those kept in silent or poorly expressed in their original strains. Here, we cloned the spinosad BGC through the Cas9‐Assisted Targeting of Chromosome segments and amplified it to five copies through a ZouA‐dependent DNA amplification system in Streptomyces coelicolor M1146. The resulting strain produced 1253.9 ± 78.2 μg l−1 of spinosad, which was about 224‐fold compared with that of the parent strain carrying only one copy of the spinosad BGC. Moreover, we further increased spinosad to 1958.9 ± 73.5 μg l−1 by the dynamic regulation of intracellular triacylglycerol degradation. Our study indicates that tandem amplification of the targeted gene cluster is particularly suitable to enhance the heterologous production of valuable NPs with efficiency and simplicity.
Anti‐ribosomal P protein antibodies in patients with systemic lupus erythematosus is associated with hyperferritinemia
Authors: Arinuma Yoshiyuki , Hirohata Shunsei , Isayama Takuya , Hasegawa Yasuhiro , Muramatsu Takumi , Kondo Junichi , Kanayama Yoshiro , Ino Kazuma , Matsueda Yu , Oku Kenji , Yamaoka Kunihiro 
Published: November 2021

AbstractAimAnti‐ribosomal P protein antibodies (anti‐ribo P) have been reported as one of the specific autoantibodies in patients with systemic lupus erythematosus (SLE) and has been demonstrated to bind and activate macrophages in vitro. Clinically, hyperferritinemia has been known to be a biomarker for macrophage activation. The aim of this study is to clarify the relationship of anti‐ribo P and clinical characteristics and biomarkers including serum ferritin in patients with SLE.MethodsClinical parameters and laboratory data were measured in patients with active SLE (N = 127) in our university hospital. The risk factors affected by anti‐ribo P were retrospectively calculated by logistic regression analysis, and the correlation of anti‐ribo P and clinical factors was demonstrated.ResultsAnti‐ribo P was significantly elevated in active SLE compared to non‐SLE diseases (P < .0001). Sensitivity and the specificity of anti‐ribo P in patients with SLE were 32.0% and 99.3%, respectively. Patients positive for anti‐ribo P had the highest risk for elevated serum ferritin (odds ratio: 8.432). Accordingly, anti‐ribo P positive patients had significantly elevated serum ferritin compared to negative patients (P = .024). A significant positive correlation was observed between the anti‐ribo P titer and the serum ferritin level (r2 = .07, t = 5.22, P = .0081), but not serum interleukin (IL)‐6 in SLE patients.ConclusionThe presence of anti‐ribo P is a risk factor for higher ferritin levels that is independent of systemic inflammation regulated by IL‐6. We speculate that anti‐ribo P could be directly associated with macrophage activation leading to hyperferritinemia in patients with SLE.
Predictive factors for concomitant pulmonary arterial hypertension at diagnosis of systemic lupus erythematosus in a Chinese population
Authors: Pan Ying , Sun Yining , He Lan 
Published: November 2021

AbstractAimTo investigate the predictive factors of pulmonary arterial hypertension (PAH) in systemic lupus erythematosus (SLE) patients.MethodThis chart review study included 408 SLE patients. We defined PAH as 2 consecutive systolic pulmonary arterial pressure (PAP) values ≥40 mm Hg by echocardiography. Demographic characteristics, clinical symptoms, autoantibodies, and laboratory tests were studied.ResultsThirty‐four patients in the SLE/PAH+ group and 374 patients in the SLE/PAH− group were analyzed. The prevalence of PAH in SLE is 8.3% in this study. The occurrences of interstitial pneumonitis, polyserositis and myocardial damage were higher in the SLE/PAH+ group (P = .001, P = .033 and P < .001, respectively). The occurrence of anti‐double‐stranded DNA and anti‐ribosomal RNA protein (anti‐rRNP) antibodies were lower in the SLE/PAH+ group (P = .003, .010). Positive rates of anti‐Sjögren’s syndrome antigen A (anti‐SSA)/Ro52 antibodies and anti‐SSB antibodies were higher in the SLE/PAH+ group (P = .046, .021). C‐reactive protein and immunoglobin G (IgG) were higher in the SLE/PAH+ group (P = .009, .005). Ejection fraction and SLE disease activity index between the 2 groups had no differences. Multivariable logistic regression indicated that interstitial pneumonitis, myocardial damage and high IgG are predictive factors for SLE‐associated PAH patients.ConclusionFrom this study, we found that interstitial pneumonitis, myocardial damage, and high IgG were predictive factors of PAH in SLE patients.
Outcomes following out‐of‐hospital cardiac arrest in the aeromedical retrieval population of the remote Top End of the Northern Territory, Australia
Authors: Urquhart Colin , Martin Jodie , Ross Mark 
Published: November 2021

AbstractObjectiveOut‐of‐hospital cardiac arrest is an event with an extremely poor prognosis. There is limited literature on the outcomes for regional Australia, with none specifically addressing remote populations. We aimed to assess out‐of‐hospital cardiac arrest outcomes in the aeromedical retrieval population of the Top End Medical Retrieval Service.DesignWe retrospectively identified all cardiac arrests, deaths and patients who had cardiopulmonary resuscitation within the aeromedical retrieval database for a 5‐year period from January 2012 to December 2016.SettingRetrieval patients across the Top End of the Northern Territory, Australia.ParticipantsAll patients within the cohort with a non‐traumatic out‐of‐hospital cardiac arrest.Main outcome measuresData were collected on outcomes as per Utstein definitions, along with patient demographics, retrieval timings and interventions.ResultsSeventy‐five patients suffering cardiac arrest were identified, with 58 having a non‐traumatic arrest in an out‐of‐hospital setting. The median age of the cohort was 40 years, and 53% had an initial shockable rhythm. Return of spontaneous circulation was achieved in 55% and 43% survived to hospital. The survival to hospital discharge and 28 days were 31% and 29%, respectively.ConclusionsAlthough the study has a small sample size and limitations on generalisability due to the restricted nature of the cohort selection, the results suggest a 28‐day survival rate is potentially comparable to other regions of Australia and the rest of the world. Further research needs to be undertaken in out‐of‐hospital cardiac arrest in remote regions to establish a true population–based cohort and ascertain where improvements can be made.
Minimal clinically important difference in days at home up to 30 days after surgery
Authors: Ferguson M. T. , Kusre S. , Myles P. S. 
Published: November 2021

SummaryPatient‐centred outcomes are increasingly recognised as crucial measures of healthcare quality. Days alive and at home up to 30 days after surgery (DAH30) is a validated and readily obtainable patient‐centred outcome measure that integrates much of the peri‐operative patient journey. However, the minimal difference in DAH30 that is clinically important to patients is unknown. We designed and administered a 28‐item survey to evaluate the minimal clinically important difference in DAH30 among adult patients undergoing inpatient surgery. Patients were approached pre‐operatively or within 2 days postoperatively. We did not study patients undergoing day surgery or nursing home residents. Patients ranked their opinions on the importance of discharge home using a Likert scale (from 1, not important at all to 6, extremely important) and the minimum number of extra days at home that would be meaningful using this scale. We recruited 104 patients; the survey was administered pre‐operatively to 45 patients and postoperatively to 59 patients. The mean (SD) age was 53.5 (16.5) years, and 51 (49%) patients were male. Patients underwent a broad range of surgery of mainly intermediate (55%) to major (33%) severity. The median minimal clinically important difference for DAH30 was 3 days; this was consistent across a broad range of scenarios, including earlier discharge home, complications delaying hospital discharge and the requirement for admission to a rehabilitation unit. Discharge home earlier than anticipated and discharge home rather than to a rehabilitation facility were both rated as important (median score = 5). Empirical data on the minimal clinically important difference for DAH30 may be useful to determine sample size and to guide the non‐inferiority margin for future clinical trials.