bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulated Wound Care as a Competence Assessment Method for Student and Registered Nurses
Authors: Kielo-Viljamaa Emilia , Ahtiala Maarit , Suhonen Riitta , Stolt Minna 
Published: October 2021

ABSTRACT

OBJECTIVE
To describe the development and use of a wound care simulation assessing RNs’ and graduating student nurses’ practical wound care competence and to describe observations of participants’ wound care competence.

METHODS
A descriptive, qualitative design was used. Data were collected in 2019 from 50 healthcare professionals and students using a simulated wound care situation and an imaginary patient case. The simulation was based on a previously developed and tested wound care competence assessment instrument, which included a 14-item checklist that assesses practical wound care competence of chronic wounds. The data were analyzed and described based on the 14 competence areas or as other competencies.

RESULTS
Participants showed competence in identification of wound infection, debridement, dressing selection, tissue type identification, and consultation. Participants’ shortcomings were related to pain assessment and management, asepsis, offloading, and documentation. Simulation was shown to be a promising tool to assess healthcare professionals’ and students’ practical wound care competence in a safe and standardized situation.

CONCLUSIONS
This study provided new information about simulation as a method to assess student nurses’ and RNs’ wound care competence. The results could be used in wound care education planning and development in both undergraduate nursing education and continuing education for nursing professionals.
Comparison of Minimally Invasive Transforaminal and Anterolateral Lumbar Interbody Fusion for Treatment of Low-grade Lumbar Spondylolisthesis
Authors: Zhu Lei , Wang Pingchuan , Zhang Liang , Feng Xinmin , Zhang Wenjie 
Published: October 2021

Study Design:
This was a retrospective cohort study.

Objective:
The aim was to compare the clinical outcomes, radiographic parameters and perioperative complications of minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) and anterolateral lumbar interbody fusion (ALLIF) for the treatment of low-grade lumbar spondylolisthesis.

Summary of Background Data:
Both MIS-TLIF and ALLIF are minimally invasive surgical methods for the treatment of lumbar degenerative diseases. However, few studies have compared the results of MIS-TLIF and ALLIF for the treatment of low-grade lumbar spondylolisthesis.

Materials and Methods:
A total of 112 patients with low-grade lumbar spondylolisthesis were divided as MIS-TLIF group (n=59, mean age 61.7 y) or ALLIF group (n=53, mean age 60.1 y) according to the treatment method. The operative time, intraoperative blood loss, and length of hospital stay were recorded. Besides, clinical outcomes were evaluated by visual analog scale and Oswestry disability index score. Radiographic parameters were assessed by disc height, lumbar lordosis, segmental lordosis, and fusion rate.

Results:
ALLIF significantly reduced operative time, intraoperative blood loss, and length of hospital stay compared with MIS-TLIF. Moreover, ALLIF was superior to MIS-TLIF in the early postoperative relief of back pain and recovery of lumbar function. However, there were no significant differences in the clinical outcomes at final follow-up between the 2 groups. The amount of change between preoperative and postoperative disc height, lumbar lordosis and segmental lordosis in ALLIF group were significantly higher than those in MIS-TLIF group (P<0.05). However, there were no significant differences in fusion rate and incidence of complications between the 2 groups.

Conclusions:
This study indicated that the final follow-up clinical outcomes, complication rate of ALLIF were similar to MIS-TLIF for the treatment of low-grade lumbar spondylolisthesis. However, ALLIF showed advantages in less surgical trauma, faster recovery, early postoperative relief of back pain, and radiographic parameters improvement.
Treatment of acute pulmonary edema by blocking VEGF-induced vascular leakage
Authors: Cao Yihai 
Published: October 2021

Abstract
Pulmonary edema induces local and systemic hypoxia in lungs and other tissues and organs, entailing the development of acute respiratory distress syndrome (ARDS). Hypoxia triggers a myriad of pathological responses, including angiogenesis and hyperpermeability of blood vessels in the lung and other tissues. Vascular endothelial growth factor, also named vascular permeability factor (VPF), is one of the key hypoxia-targeted genes. It is probably the most potent VPF in the body. In this article, I will discuss the possibilities and mechanistic insights of blocking the VEGF signaling pathway for treating acute pulmonary edema. In particular, anti-VEGF drugs for treating Covid-19-induced pulmonary edema will be discussed.
Malignant hyperthermia in severe COVID-19: 2 case reports
Authors: Ehteshami-Afshar Solmaz , Nikooie Roozbeh , Reddy Pranav , Chichra Astha , Siegel Mark D. 
Published: October 2021

Abstract
Malignant hyperthermia is a rare but potentially fatal condition. We present 2 cases of young patients with coronavirus disease 2019 (COVID-19) requiring intubation for hypoxic respiratory failure who both developed significant hyperthermia post intubation and were suspected to have malignant hyperthermia. However, the 2 patients had different responses to conservative management and dantrolene. These cases highlight the increased challenge imposed by intubation complications when managing patients with COVID-19.
Nerve pathology and neuropathic pain after whiplash injury: a systematic review and meta-analysis
Authors: Fundaun Joel , Kolski Melissa , Baskozos Georgios , Dilley Andrew , Sterling Michele , Schmid Annina B. 
Published: October 2021

Abstract
There is no clear understanding of the mechanisms causing persistent pain in patients with whiplash-associated disorder (WAD). The aim of this systematic review was to assess the evidence for nerve pathology and neuropathic pain in patients with WAD. EMBASE, PubMed, CINAHL (EBSCO), and MEDLINE were searched from inception to September 1, 2020. Study quality and risk of bias were assessed using the Newcastle–Ottawa Quality Assessment Scales. Fifty-four studies reporting on 390,644 patients and 918 controls were included. Clinical questionnaires suggested symptoms of predominant neuropathic characteristic in 34% of patients (range 25%-75%). The mean prevalence of nerve pathology detected with neurological examination was 13% (0%-100%) and 32% (10%-100%) with electrodiagnostic testing. Patients independent of WAD severity (Quebec Task Force grades I-IV) demonstrated significantly impaired sensory detection thresholds of the index finger compared with controls, including mechanical (SMD 0.65 [0.30; 1.00] P < 0.005), current (SMD 0.82 [0.25; 1.39] P = 0.0165), cold (SMD −0.43 [−0.73; −0.13] P = 0.0204), and warm detection (SMD 0.84 [0.25; 1.42] P = 0.0200). Patients with WAD had significantly heightened nerve mechanosensitivity compared with controls on median nerve pressure pain thresholds (SMD −1.10 [−1.50; −0.70], P < 0.0001) and neurodynamic tests (SMD 1.68 [0.92; 2.44], P = 0.0004). Similar sensory dysfunction and nerve mechanosensitivity was seen in WAD grade II, which contradicts its traditional definition of absent nerve involvement. Our findings strongly suggest a subset of patients with WAD demonstrate signs of peripheral nerve pathology and neuropathic pain. Although there was heterogeneity among some studies, typical WAD classifications may need to be reconsidered and include detailed clinical assessments for nerve integrity.
Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain
Authors: Wang Yaomin , Scarneo Scott A. , Kim Shin Hyung , Zhang Xin , Chen Jiegen , Yang Kelly W. , Hughes Philip , Haystead Timothy , Nackley Andrea G. 
Published: October 2021

Abstract
Heat shock protein 90 (Hsp90) is a ubiquitously expressed integral cellular protein essential for regulating proteomic stress. Previous research has shown that Hsp90 regulates critical signaling pathways underlying chronic pain and inflammation. Recent discovery of membrane bound ectopic Hsp90 (eHsp90) on tumor cells has shown that Hsp90 induction to the plasma membrane can stabilize disease-relevant proteins. Here, we characterize eHsp90 expression in a mouse model of inflammation and demonstrate its role in nociception and pain. We found that intraplantar complete Freund adjuvant (CFA) induced robust expression of eHsp90 on the cell membranes of primary afferent nociceptors located in the L3-L5 dorsal root ganglia (DRG), bilaterally, with minimal to no expression in other tissues. Complete Freund adjuvant–induced increases in eHsp90 expression on lumbar DRG were significantly greater in females compared with males. Furthermore, exogenous Hsp90 applied to primary Pirt-GCaMP3 nociceptors induced increases in calcium responses. Responses were estrogen-dependent such that greater activity was observed in female or estrogen-primed male nociceptors compared with unprimed male nociceptors. Treatment of mice with the selective eHsp90 inhibitor HS-131 (10 nmol) significantly reversed CFA-induced mechanical pain, thermal heat pain, and hind paw edema. Notably, a higher dose (20 nmol) of HS-131 was required to achieve analgesic and anti-inflammatory effects in females. Here, we provide the first demonstration that inflammation leads to an upregulation of eHsp90 on DRG nociceptors in a sex-dependent manner and that inhibition of eHsp90 reduces nociceptor activity, pain, and inflammation. Thus, eHsp90 represents a novel therapeutic axis for the development of gender-tailored treatments for inflammatory pain.
Disruption of working memory and contralateral delay activity by nociceptive stimuli is modulated by task demands
Authors: Wagenaar-Tison Alice , Deldar Zoha , Northon Stéphane , Brisson Benoit , Blanchette Isabelle , Piché Mathieu 
Published: October 2021

Abstract
Top–down processes allow the selection and prioritization of information by limiting attentional capture by distractors, and these mechanisms depend on task demands such as working memory (WM) load. However, bottom–up processes give salient stimuli a stronger neuronal representation and provoke attentional capture. The aim of this study was to examine the effect of salient nociceptive stimuli on WM while manipulating task demands. Twenty-one healthy participants performed a change detection task during which they had to determine whether 2 successive visual arrays were different or the same. Task demands were modulated by manipulating the WM load (set size included 2 or 4 objects to recall) and by the correspondence between the 2 successive visual arrays (change vs no change). Innocuous stimuli (control) or nociceptive stimuli (distractors) were delivered during the delay period between the 2 visual arrays. Contralateral delay activity and laser-evoked potentials were recorded to examine neural markers of visual WM and nociceptive processes. Nociceptive stimuli decreased WM performance depending on task demands (all P < 0.05). Moreover, compared with control stimuli, nociceptive stimuli abolished the increase in contralateral delay activity amplitude for set size 4 vs set size 2 (P = 0.04). Consistent with these results, laser-evoked potential amplitude was not decreased when task demands were high (P = 0.5). These findings indicate that WM may shield cognition from nociceptive stimuli, but nociceptive stimuli disrupt WM and alter task performance when cognitive resources become insufficient to process all task-relevant information.
Can Quetiapine Prolong the Antidepressant Effect of Ketamine?
Authors: Amiaz Revital , Saporta Rachel , Noy Adam , Berkenstadt Haim , Weiser Mark 
Published: October 2021

Abstract

Purpose
Ketamine, a noncompetitive, high-affinity antagonist of the N-methyl-d-aspartate-type glutamate receptor, has a rapid effect in patients with treatment-resistant disorder, but many patients who respond to intravenous ketamine relapse within several days. The objective of this study was to examine the long-term outcome of patients' mood 5 years after ketamine treatment.

Methods
Sixteen electroconvulsive therapy referrals received at least 1 intravenous ketamine treatment in addition to their stable antidepressant medications. Depression was evaluated using the Inventory of Depressive Symptomatology–Clinician-Rated, Hamilton Rating Scales for Depression, and Montgomery-Åsberg Depression Rating Scale. Anxiety was measured using the Hamilton Rating Scale.

Results
Of 16 patients treated, 6 achieved complete remission, 3 partially responded, and 7 did not respond. At baseline, all patients were treated with antidepressants, 14 patients were also treated with neuroleptics, of whom 5 patients were treated with quetiapine. The time to relapse in the 5 patients taking quetiapine was significantly longer than in patients who were taking other neuroleptics (965.83 ± 824.68 vs 80.5 ± 114.3, Z = 7.001, P = 0.0001). At the 5-year follow-up, 3 of the patients taking quetiapine maintained their remission. Overall levels of depression and anxiety at all times were improved in comparison to baseline.

Conclusions
Our follow-up results suggest that the combination of quetiapine and ketamine can prolong time to relapse after ketamine treatment in patients with treatment-resistant disorder.
Ductus Reuniens and Its Possible Role in Menière's Disease
Authors: Hornibrook Jeremy , Mudry Albert , Curthoys Ian , Smith Christopher M. 
Published: October 2021

Objective:
After 160 years the true underlying cause of Meniere's disease remains enigmatic. The aim of our study is to discuss the possible implication of an obstruction of the ductus reuniens as a cause in Menière's disease.

Methodology:
We first conducted an historical study of the description of the ductus reuniens. We then reviewed the literature regarding ductus reuniens obstruction in animal experiments, human post-mortem studies and living ear imaging. We completed its description by modern microCT imaging. Limited knowledge on the fate of dislodged saccular otoconia is summarized. The possible implications for Meniere's attacks are discussed.

Results:
Victor Hensen was the first to describe the ductus reuniens in 1863. He described its length and width and predicted that saccular otoconia might enter the ductus and the cochlea. On microCT the narrowest width of the human ductus reuniens was 0.14 mm. The literature reports cochlear endolymphatic hydrops occurring after animal experimental obstruction of the duct. Human postmortem studies have confirmed saccular otoconial clumps entering the ductus and the cochlea. A postmortem study has shown sites of endolymphatic obstruction, and imaging speculates on blockages in ears with Meniere's disease. Dislodged utricular otoconia can be in clumps of otolithic membranes.

Conclusion:
Blockages of the ductus reuniens and at other endolymphatic system sites appear to be a feature in Meniere's disease ears. The blockages have been postulated to be saccular otoconia either causing or aggravating hydrops. This could be consistent with observed nystagmus reversals during attacks as the endolymphatic sac attempts to clear the hydrops and the otoconia.
Neuroimaging Systematic Review in Persistent Postural-Perceptual Dizziness: The Elaborate Alterations in the Delicate Network to Remain Balanced
Authors: Teh Carren Sui-Lin , Mah Michelle Clare , Rahmat Kartini , Prepageran Narayanan 
Published: October 2021

Objectives:
Persistent postural-perceptual dizziness (PPPD) is a chronic functional vestibular disorder that may have normal physical examination, clinical laboratory testing and vestibular evaluation. However, advances in neuroimaging have provided new insights in brain functional connectivity and structure in patients with PPPD. This systematic review was aimed at identifying significant structural or alterations in functional connectivity in patients with PPPD.

Databases Reviewed:
Science Direct, Pubmed, Embase via Ovid databases, and Cochrane library.

Methods:
This review following the guidelines of PRISMA, systematically and independently examined papers published up to March 2021 which fulfilled the predetermined criteria. PROSPERO Registration (CRD42020222334).

Results:
A total of 15 studies were included (MRI = 4, SPECT = 1, resting state fMRI = 4, task-based fMRI = 5, task-based fMRI + MRI = 1). Significant changes in the gray matter volume, cortical folding, blood flow, and connectivity were seen at different brain regions involved in vestibular, visual, emotion, and motor processing.

Conclusion:
There is a multisensory dimension to the impairment resulting in chronic compensatory changes in PPPD that is evident by the significant alterations in multiple networks involved in maintaining balance. These changes observed offer some explanation for the symptoms that a PPPD patient may experience.
Systematic Review Registration: This study is registered with PROSPERO (CRD42020222334).
Relationship Between Handgrip Strength and Metabolic Syndrome Among Middle-Aged and Elderly Cancer Survivors
Authors: Kim Ji-Su , Seo Yeji 
Published: October 2021

Background
The number of middle-aged and elderly cancer survivors is rising. Metabolic syndrome, which has been established as an important risk factor for mortality and cardiovascular disease, has also been linked to quality of life in middle-aged and elderly cancer survivors. Recent studies documented a relationship between handgrip strength and metabolic syndrome.

Objective
The aim of this study was to investigate the relationship between relative handgrip strength in middle-aged and elderly cancer survivors and metabolic syndrome in a national population-based sample from Korea.

Methods
This was a cross-sectional, secondary descriptive analysis of data from the sixth to seventh (2014–2018) Korea National Health and Nutrition Examination Survey (KNHANES VI-VII). A final total of 1096 cancer survivors aged 45 years and older were selected.

Results
Lower relative handgrip strength was linked to a higher risk of metabolic syndrome. For men, the adjusted odds ratio for having metabolic syndrome in individuals with a relative handgrip strength score of the 2 Quartile was 4.43 (95% confidence interval, 2.25–8.71) compared with the 4 Quartile (reference) (P < .001), whereas for women, this was 3.67 (95% confidence interval, 2.06–6.53) (P < .001).

Conclusions
Lower relative handgrip strength is correlated with components of metabolic syndrome and is a risk factor for metabolic syndrome among middle-aged and elderly cancer survivors.

Implications for Practice
Physicians and nurses need to identify and monitor the handgrip strength for managing the risk of metabolic syndrome among middle-aged and elderly cancer survivors. Preventive and therapeutic programs that focus on handgrip strength should be developed to prevent metabolic syndrome during their rehabilitation.
Characteristics of Asian-American Breast Cancer Survivors Retained in a 3-Month Technology-Based Intervention
Authors: Yi Jee-Seon , Chee Wonshik , Im Eun-Ok 
Published: October 2021

Background
Technology-based intervention programs are known to be effective in approaching socially excluded groups or racial/ethnic minorities, including this specific population. However, the retention of participants in technology-based intervention studies is far more complicated and challenging compared with conventional studies targeting racial/ethnic minorities.

Objective
This study aimed to identify the complex characteristics of the groups within Asian American breast cancer survivors who were successfully retained in a 3-month technology-based intervention study.

Methods
This secondary analysis of the data from a larger ongoing intervention study included 155 Asian American breast cancer survivors. Major variables were measured using multiple instruments including the questions on characteristics of the participants, the Personal Resource Questionnaire, perceived isolation, Memorial Symptom Assessment Scale-Short Form, Cancer Behavior Inventory, 34-item Supportive Care Needs Survey Short Form, and Functional Assessment of Cancer Therapy Scale–Breast Cancer. Data analyses were done through χ
2 tests, t tests, and decision tree analyses.

Results
The retention rates differed by subethnicity (P = .025), immigration age (P < .001), and stage of breast cancer (P = .003). The decision tree indicated four groups with the highest probability of retention: (a) those who were diagnosed with stage II, III, or IV breast cancer, (b) those who immigrated to the United States after turning 31 years old, and (c) those who had high perceived barriers.

Conclusion
This study provides directions for future retention strategies for technology-based interventions among Asian American breast cancer survivors.

Implications for Practice
Participants’ characteristics need to be considered in developing retain strategies for technology-based interventions among Asian American breast cancer survivors.
Nursing Students' Intention to Report Medication Errors
Authors: Secginli Selda , Nahcivan Nursen O. , Bahar Zuhal , Fernandez Ritin , Lapkin Samuel 
Published: October 2021

Background
Reporting, investigating, and full disclosure of medication errors (MEs) is a fundamental component of patient safety. Therefore, determining nursing students' intention to report MEs is important.

Purpose
This study examined the factors related to nursing students' intention to report MEs and the use of the Turkish version of the Theory of Planned Behavior Medication Safety Questionnaire (TPB-MSQ-T).

Methods
A descriptive cross-sectional design was used with a sample of 227 undergraduate nursing students in Istanbul, Turkey. Students' intentions to report MEs were measured using an online TPB-MSQ-T. Quantitative analysis was conducted.

Results
Attitudes and perceived behavioral control (PBC) were significant predictors of intention to report MEs (P = .05 and P = .01, respectively), but subjective norms did not predict it (P = .11). The Cronbach's α of the questionnaire was 0.88.

Conclusions
Attitude and PBC are important determinants of nursing students' intention to report MEs. The TPB-MSQ-T can be used for identifying the main determinants of intention to report MEs.
Universal Design for Learning
Authors: Davis Diane , McLaughlin Maureen Kirkpatrick , Anderson Kelley M. 
Published: October 2021

Background:
Blended learning (BL), the combining of face-to-face and online learning, is gaining prominence in nursing education in response to advances in evidence-based learning using technology, the diverse and evolving needs of nursing learners, and unpredictable events impacting nursing education.

Problem:
Blended learning requires nursing learners and educators to adapt to new modalities and educators to re-envision learning environments. However, BL lacks an educational framework to guide implementation and is not well explored in the nursing literature.

Approach:
Universal design for learning (UDL) is applied as a framework for BL in nursing education.

Conclusions:
Universal design for learning provides a framework for BL to enable nursing educators, learners, and educational institutions to reimagine teaching and learning in novel ways that incorporate emerging evidence and address new challenges. Blended learning, within the context of UDL, offers opportunities for diverse and inclusive learning. Research is needed to guide the implementation of BL best practices within a UDL framework.