bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety Monitoring of Mpox Vaccines in Adults Aged 18–64 Years during the 2022 Mpox Outbreak in the U.S.
Authors: Gruber Joann F. , Matuska Kathryn , Zelaya Carla E. , Wang Jing , McMahill-Walraven Cheryl N , Peetluk Lauren , Secora Alex , Krishnakumar Shwetha , Hu Mao , Amend Kandace L. , Song Jennifer , Beachler Daniel C. , Lloyd Patricia C. , Chillarige Yoganand , Gwira Jane A. , Tarazi Wafa , Clarke Tainya C. , Djibo Djeneba Audrey , Forshee Richard A. , Shoaibi Azadeh , Anderson Steven A. 
Published: December 2024

AbstractTwo vaccines (JYNNEOS; ACAM2000) were available in the United States to prevent mpox during the 2022 clade II mpox outbreak with the majority of people receiving JYNNEOS. As part of the Biologics Effectiveness and Safety (BEST) Initiative, FDA monitored the safety of JYNNEOS using three commercial health plan claims databases supplemented with local and state Immunization Information System data. We assessed vaccine uptake, described the vaccinated population, monitored rates of 11 potential adverse events (AEs) following vaccination, and compared the observed AE rates to expected background rates. There were 152,001 JYNNEOS doses administered. Of the 92,340 people receiving at least one JYNNEOS dose, most were males (93.1%), aged 25–44 years (63.3%), lived in urban areas (98.7%), and 64.2% received a second dose. AE rates following JYNNEOS doses were similar to expected background rates. Additional safety studies of larger vaccinated populations may be needed to evaluate rare AEs including myocarditis/pericarditis.
Metabolomic profiling reveals grade-specific niacinamide accumulation and its therapeutic Potential via SIRT1-CD38-EMT axis modulation in cervical cancer progression
Authors: Jaiswal Shivani , Mishra Vivek , Majumder Srija , Wangikar Pramod P. , Sengupta Shinjinee 
Published: December 2024

AbstractDespite the availability of new therapies for cervical cancer, innovative strategies are essential to address challenges related to drug resistance and high toxicity. The present study focuses on the metabolic profiling of cervical carcinoma using non-targeted metabolomics approach using liquid chromatography-mass spectrometry. Our study identified over 100 metabolites in cervical tissue samples (both cancerous and adjacent normal) using HILIC and reversed-phase chromatography in the positive and negative ionization modes. The major metabolic alterations included changes in glycolysis, the citric acid cycle, amino acid metabolism, nucleotide metabolism, and nicotinamide metabolism in a grade-dependent manner. Interestingly, metabolic differences between HPV-positive and HPV-negative tumors included elevated arginine and proline metabolism, nicotinamide metabolism, and phosphatidylcholine biosynthesis. We further validated our findings by analyzing transcriptomics datasets from the Gene Expression Omnibus database to understand the expression patterns of the underlying genes involved in the dysregulated pathways. We observed that nicotinamide metabolism exhibits significant effects in lower-grade cervical cancers and specific HPV genotypes. We treated cervical cancer cell lines with niacinamide (NAM), an amide form of niacin, to evaluate its potential therapeutic efficacy. NAM treatment modulated NAD+ metabolism with key players such as CD38, PARP, NAMPT, and SIRT1, promoting apoptosis and inhibiting cell proliferation in cervical cancer cells. Importantly, the metabolic responses differed between the HPV-positive SiHa cells and HPV-negative C33A cells, reflecting distinct NAD+ metabolic adaptations. The study highlights the metabolic adaptation or shifts in cancer progression and provides insights into NAM’s molecular mechanisms and therapeutic potential for precision medicine in cervical cancer.
Eukaryotic composition across seasons and social groups in the gut microbiota of wild baboons
Authors: Chege Mary , Ferretti Pamela , Webb Shasta , Macharia Rosaline W. , Obiero George , Kamau Joseph , Alberts Susan C. , Tung Jenny , Akinyi Mercy Y. , Archie Elizabeth A 
Published: December 2024

AbstractBackgroundAnimals coexist with complex microbiota, including bacteria, viruses, and eukaryotes (e.g., fungi, protists, and helminths). While the composition of bacterial and viral components of animal microbiota are increasingly well understood, eukaryotic composition remains neglected. Here we characterized eukaryotic diversity in the microbiomes in wild baboons and tested the degree to which eukaryotic community composition was predicted by host social group membership, sex, age, and season of sample collection.ResultsWe analyzed a total of 75 fecal samples collected between 2012 and 2014 from 73 wild baboons in the Amboseli ecosystem in Kenya. DNA from these samples was subjected to shotgun metagenomic sequencing, revealing members of the kingdoms Protista, Chromista, and Fungi in 90.7%, 46.7%, and 20.3% of samples, respectively. Social group membership explained 11.2% of the global diversity in gut eukaryotic species composition, but we did not detect statistically significant effect of season, host age, and host sex. Across samples, the most prevalent protists wereEntamoeba coli(74.66% of samples),Enteromonas hominis(53.33% of samples), andBlastocystis subtype3 (38.66% of samples), while the most prevalent fungi includedPichia manshurica(14.66% of samples), andOgataea naganishii(6.66% of samples).ConclusionsProtista, Chromista, and Fungi are common members of the gut microbiome of wild baboons. More work on eukaryotic members of primate gut microbiota is essential for primate health monitoring and management strategies.
Statins inhibit onco-dimerization of the 4Ig isoform of B7-H3
Authors: Sutton Margie N. , Glazer Sarah E. , Zaki Ajlan Al , Napoli Arianna , Yang Ping , Bhosale Priya , Liu Jinsong , Gammon Seth T. , Piwnica-Worms David 
Published: December 2024

AbstractB7-H3 (CD276), a member of the B7-family of immune checkpoint proteins, has been shown to have immunological and non-immunological effects promoting tumorigenesis [1, 2] and expression correlates with poor prognosis for many solid tumors, including cervical, ovarian and breast cancers [3–6]. We recently identified a tumor-cell autochthonous tumorigenic role for dimerization of the 4Ig isoform of B7-H3 (4Ig-B7-H3) [7], where 4Ig-B7-H3 dimerizationin cisactivated tumor-intrinsic cellular proliferation and tumorigenesis pathways, providing a novel opportunity for therapeutic intervention. Herein, a live cell split-luciferase complementation strategy was used to visualize 4Ig-B7-H3 homodimerization in a high-throughput small molecule screen (HTS) to identify modulators of this protein-protein interaction (PPI). Notably, the HTS identified several compounds that converged on lipid metabolism (including HMG-CoA reductase inhibitors, also known as statins) as significant inhibitors of 4Ig-B7-H3 dimerization (p < 0.01).In vitroandin vivomurine studies provided evidence that statin-mediated disruption of 4Ig-B7-H3 dimerization was associated with anti-tumor effects. Statin-mediated anti-cancer efficacy was selective for B7-H3-expressing tumors and retrospective analysis of clinical tumor specimens supported the hypothesis that concurrent statin use enhanced clinical outcomes for patients in a B7-H3 restricted manner. Thus, disruption of 4Ig-B7-H3 dimerization provides an unanticipated molecular mechanism linking statin use in cancer therapy and prevention with immune checkpoint.
The first comorbidity networks in companion dogs in the Dog Aging Project
Authors: Fang Antoinette , Kumar Lakshin , Creevy Kate E ,   the Dog Aging Project Consortium, Promislow Daniel E.L. , Ma Jing 
Published: December 2024

AbstractComorbidity and its association with age are of great interest in geroscience. However, there are few model organisms that are well-suited to study comorbidities that will have high relevance to humans. In this light, we turn our attention to the companion dog. The companion dog shares many morbidities with humans. Thus, a better understanding of canine comorbidity relationships could benefit both humans and dogs. We present an analysis of canine comorbidity networks from the Dog Aging Project, a large epidemiological cohort study of companion dogs in the United States. We included owner-reported health conditions that occurred in at least 60 dogs (n=166) and included only dogs that had at least one of those health conditions (n=26,523). We constructed an undirected comorbidity network using a Poisson binomial test, adjusting for age, sex, sterilization status, breed background (i.e., purebred vs. mixed-breed), and weight. The comorbidity network reveals well-documented comorbidities, such as diabetes with blindness and hypertension with chronic kidney disease. In addition, this network also supports less well-studied comorbidity relationships, such as proteinuria with anemia. A directed comorbidity network accounting for time of reported condition onset suggests that diabetes occurs before cataracts, which is consistent with the canine literature. Analysis of age-stratified networks reveals that global centrality measures increase with age and are the highest in the Senior group compared to the Young Adult and Mature Adult groups. Our results suggest that comorbidity network analysis is a promising method to enhance clinical knowledge and canine healthcare management.
Tiled Amplicon Sequencing Enables Culture-free Whole-Genome Sequencing of Pathogenic Bacteria From Clinical Specimens
Authors: Kalinich Chaney C , Gonzalez Freddy L , Osmaston Alice , Breban Mallery I , Distefano Isabel , Leon Candy , Sheen Patricia , Zimic Mirko , Coronel Jorge , Tan Grace , Crudu Valeriu , Ciobanu Nelly , Codreanu Alexandru , Solano Walter , Ráez Jimena , Allicock Orchid M , Chaguza Chrispin , Wyllie Anne L , Brandt Matthew , Weinberger Daniel M , Sobkowiak Benjamin , Cohen Ted , Grandjean Louis , Grubaugh Nathan D , Redmond Seth N 
Published: December 2024

AbstractPathogen sequencing is an important tool for disease surveillance and demonstrated its high value during the COVID-19 pandemic. Viral sequencing during the pandemic allowed us to track disease spread, quickly identify new variants, and guide the development of vaccines. Tiled amplicon sequencing, in which a panel of primers is used for multiplex amplification of fragments across an entire genome, was the cornerstone of SARS-CoV-2 sequencing. The speed, reliability, and cost-effectiveness of this method led to its implementation in academic and public health laboratories across the world and adaptation to a broad range of viral pathogens. However, similar methods are not available for larger bacterial genomes, for which whole-genome sequencing typically requiresin vitroculture. This increases costs, error rates and turnaround times. The need to culture poses particular problems for medically important bacteria such asMycobacterium tuberculosis,which are slow to grow and challenging to culture. As a proof of concept, we developed two novel whole-genome amplicon panels forM. tuberculosisandStreptococcus pneumoniae. Applying our amplicon panels to clinical samples, we show the ability to classify pathogen subgroups and to reliably identify markers of drug resistance without culturing. Development of this work in clinical settings has the potential to dramatically reduce the time of diagnosis of drug resistance for multiple drugs in parallel, enabling earlier intervention for high priority pathogens.
Pressure weakens coupling strength in In and Sn elemental superconductors
Authors: Khasanov Rustem , Ummarino Giovanni A. 
Published: December 2024

The pressure dependence of the thermodynamic critical field Bc in elemental indium (In) and tin (Sn) superconductors was studied by means of muon-spin rotation/relaxation. Pressure enhances the deviation of Bc(T) from the parabolic behavior expected for a typical type-I superconductor, suggesting a weakening of the coupling strength α=〈Δ〉/kBTc (〈Δ〉 is the average value of the superconducting energy gap, Tc is the transition temperature, and kB is the Boltzmann constant). As pressure increases from 0.0 to ≃3.0 GPa, α decreases linearly, approaching the limiting weak-coupling Bardeen-Cooper-Schrieffer (BCS) value αBCS≃1.764. Analysis of the data within the framework of Eliashberg theory reveals that only part of the pressure effect on α can be attributed to the hardening of the phonon spectra, reflected by a decrease in the electron-phonon coupling constant. Nearly 40% of the effect is caused by an increased anisotropy of the superconducting energy gap.

Published by the American Physical Society
2024
Superposition of
CP
-even and
CP
-odd Higgs resonances: Explaining the 95 GeV excesses within a two-Higgs-doublet model
Authors: Benbrik Rachid , Boukidi Mohammed , Moretti Stefano 
Published: December 2024

We propose an explanation for the observed excesses around 95 GeV in the diphoton and ditau invariant mass distributions, as reported by the CMS collaboration at the Large Hadron Collider. These findings are complemented by a long-standing discrepancy in the bb¯ invariant mass at the Large Electron-Positron Collider. Additionally, the ATLAS collaboration has reported a corroborative excess in the diphoton final state within the same mass range, albeit with slightly lower significance. Our approach involves the superposition of CP-even and CP-odd Higgs bosons within the type-III two-Higgs doublet model to simultaneously explain these excesses at 1σ confidence level, while remaining consistent with current theoretical and experimental constraints.

Published by the American Physical Society
2024
Identifying facilitators and barriers associated with caring for individuals with intellectual disability who were at risk of hospital admission
Authors: Morris Rohan , Chadwick Laura , Hasan Syeda , Iqbal Ameera , Patil Dipti 
Published: December 2024

Purpose
This study aims to explore the experiences of professional carers for people with intellectual disabilities who were “at risk” of hospital admission and to identify factors which were helpful or restrictive in the support received from health-care services during this time.

Design/methodology/approach
Semi-structured interviews were conducted with eight professional carers from NHS trusts. Data was analysed using thematic analysis.

Findings
Three main themes and 11 subthemes were identified. The first theme discusses the processes implemented to facilitate change while the person was at risk of hospital admission. The second theme identifies social and environmental factors increasing risk of hospitalisation. The third theme was the support received by staff.

Originality/value
To the best of the authors’ knowledge, this study was the first to gather and analyse data on carer’s experiences in supporting an individual with intellectual disability who is at risk of hospital admission within the locality of Greater Manchester.
Modelling the future of meat consumption in Poland: an agent-based approach
Authors: Akhavan Hezaveh Shahriar , Adamczyk Dominika , Stasiuk Katarzyna , Maison Dominika 
Published: December 2024

PurposeThe global dietary landscape is increasingly witnessing a shift in meat consumption patterns. However, an important question still concerns the direction in which these changes will continue and to what extent, in the near future, most consumers will completely give up meat products in their diet or will only limit their consumption. The second question is who is most susceptible to reducing meat in their diet and who will resist this trend. When looking for an answer to those questions, we employed an agent-based model (ABM) to analyse the data from a nationally representative survey conducted in Poland.Design/methodology/approachThe model takes into account key factors influencing dietary choices through the channel of social influence, including health and ethical concerns, locus of control, food neophobia and meat eating justification.FindingsOur simulations indicate the future dominance of reducetarianism, an upswing in vegan/vegetarianism, and a decline in omnivorism. Additionally, distinct dietary trajectories are emerging among different demographic groups, often echoing initial disparities or unveiling new patterns. The study further confirms the importance of individuals as embedded actors in the transformation of the food system.Originality/valueThe results offer a micro-based understanding of the evolution of dietary patterns, highlighting the value of the ABM in forecasting eating behaviour.
The application of unmanned aerial vehicles (UAVs) for health and safety management in the construction industry
Authors: Pittri Hayford , Godawatte Godawatte Arachchige Gimhan Rathnagee , Agyekum Kofi , Dompey Annabel Morkporkpor Ami , Botchway Benjamin , Narh Evans 
Published: December 2024

PurposeAs construction project designs grow in complexity, the challenges associated with project monitoring also escalate. Therefore, it is recommended that cutting-edge technologies like unmanned aerial vehicles (UAVs) be incorporated to alleviate some of the issues encountered during the execution of construction projects. This paper examines the utilisation and barriers of UAV applications for health and safety (H&S) management in the construction industry.Design/methodology/approachAdopting a quantitative method for the study, data were collected from 408 construction professionals in the Ghanaian construction industry (GCI) with a questionnaire using the convenience and snowball sampling techniques. The collected data were analysed using both descriptive and inferential statistics.FindingsThe study reveals a low level of UAV adoption in the GCI, with most firms not using UAVs for H&S management. Key barriers identified include technical challenges, high costs, lack of training, limited government support and resistance to new technologies. Despite the recognised potential of UAVs in improving construction safety, their adoption remains limited due to these obstacles. Conclusively, this study recommends measures that would propel the espousal of UAVs for H&S management in the construction industry.Originality/valueThe results of this research shed light on a relatively unexplored area within the construction sector, particularly in a developing country like Ghana. By providing empirical evidence and insights, the study contributes to the broader understanding of how innovative technologies can be leveraged for H&S management in emerging economies.
The linkage of frontline employees’ neuroticism, rumination and negative affect: a moderated moderated mediation model
Authors: Hu Wan-Hsien , Lin Chen-Ju 
Published: December 2024

Purpose
Drawing on response style theory and conservation of resources theory, this study aims to examine how neuroticism indirectly influences negative affect via rumination, and whether this mediating effect is moderated directly by individual resources (i.e. emotion regulation) and indirectly by social resources (i.e. perceived organizational support [POS]).

Design/methodology/approach
A total of 181 valid responses were collected using two-wave self-reported questionnaires in Taiwan, and the research hypotheses were tested using partial least squares regression.

Findings
The results showed that when both emotion regulation and POS are low, neuroticism has a positive indirect effect on negative affect via rumination. However, this effect weakens or becomes insignificant under other conditions.

Originality/value
The findings of this study offer a more in-depth examination of the relationships among the traits, rumination, negative affect and both internal and external resources of frontline employees in the service industries. Neuroticism, as a personality trait, is not easily changed. Therefore, helping frontline employees at service sites improve their rumination, training them to regulate their emotions and enhancing the POS can be useful strategies for managers and human resource departments to pursue.
Is income inequality – conflicts nexus moderated by the quality of governance? Insight from sub-Saharan Africa
Authors: Olaoye Olumide Olusegun , Omokanmi Olatunde Julius , Tabash Mosab I. 
Published: December 2024

PurposeThe aim of this study is twofold. First, the study examines the effect of income inequality on conflicts in sub-Saharan Africa (SSA). Second, the study unveils the role of governance in income inequality – conflicts in sub-Saharan Africa (SSA).Design/methodology/approachThe study adopts the ordinary least square estimation technique (OLS) as the baseline model. However, given that so many panel data models exhibit some form of cross-sectional and temporal dependence, the study also adopts the Driscoll–Kraay cross-sectional and spatial-consistent covariance matrix estimator.FindingsThe study finds that income inequality fuels conflicts in SSA. Similarly, the results show that an increase in the quality of governance reduces conflicts. Importantly, the result shows that the quality of governance mitigates the negative effects of income inequality on conflicts in SSA. The research and policy implications are discussed.Originality/valueThe study examines the role governance in income inequality – conflicts nexus in SSA.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-01-2024-0055
An interpersonal perspective to study workplace favoritism and employees’ motivation to hold multiple jobs
Authors: Mishra Sovanjeet , Singh Anupriya , Srivastava Shalini 
Published: December 2024

PurposeThe reasons for employees’ multiple jobholding have often been explored from economic and aspirational standpoints, and the role of workplace conditions that may encourage employees’ multiple jobholding remains largely overlooked. We examine the linkage between workplace favoritism and employees’ multiple jobholding motivations. Utilizing the conservation of resources as our theoretical framework, we also explored the underlying role of job insecurity and psychological contract violation.Design/methodology/approachWe collected data using qualitative and quantitative methods. To gauge multiple jobholding motivations, we collected data from employees in Indian organizations using both qualitative (N = 44) and quantitative (N = 180, N = 205, N = 251) methods. A mediation model was tested using two-wave data gathered from 251 employees working with varied organizations located in North India. Variance-based SmartPLS was used to test the hypothesized relationships.FindingsA positive and significant association was found between workplace favoritism and employees’ multiple jobholding motivations. Job insecurity and psychological contract violation emerged as significant mediators in this process.Originality/valueThrough qualitative and quantitative studies, we developed and tested a measure of employees’ motivations to hold multiple jobs. The study uncovers the role of adverse workplace conditions in encouraging these motivations and sheds light on how workplace favoritism translates into employees’ holding multiple jobs.