bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in transdermal fentanyl utilisation and fatal fentanyl overdose across Australia (2003–2015)
Authors: Rahman Shafkat , Trussell Alex , Pearson Sallie‐Anne , Buckley Nicholas A. , Karanges Emily A. , Cairns Rose , Litchfield Melisa , Todd Adam , Gisev Natasa 
Published: October 2021

AbstractIntroductionFentanyl‐related overdose is an ongoing concern among countries with high prescription opioid utilisation. This study examines trends in transdermal fentanyl utilisation and fatal fentanyl overdose across Australia between 2003 and 2015, overall, and by age/sex.MethodsThis was a retrospective nationwide study of prescription dispensings and coronial records. Transdermal fentanyl utilisation was examined using Pharmaceutical Benefits Scheme dispensing records. Details of fatal fentanyl overdoses were extracted from the National Coronial Information System.ResultsTransdermal fentanyl utilisation increased 5.1‐fold between 2003 and 2015, from 0.28 to 1.39 mg/1000 population/day and was consistently higher among females and adults aged ≥85 years. The utilisation of higher strength patches (75 and 100 mcg/h) was more common among males aged 25–44 years. A total of 291 fatal fentanyl overdoses were recorded, increasing from no recorded deaths in 2003 to 2.23 deaths/1 000 000 population in 2015. Rates were higher among males (increasing from 0 to 3.72 deaths/1 000 000 population) and for adults aged 25–44 years (increasing from 0 to 5.34 deaths/1 000 000 population). The number of deaths/kg fentanyl dispensed was highest among males aged <25 years (45.45, 95% confidence interval 21.80–83.59). Most deaths (70.1%) involved the intravenous administration of fentanyl from transdermal patches.Discussion and ConclusionsRates of transdermal fentanyl utilisation and fatal fentanyl overdose across Australia increased between 2003 and 2015. Although transdermal fentanyl utilisation was consistently greater among females and older adults, rates of fatal fentanyl overdose were highest among younger males. Interventions to reduce extramedical use among this high‐risk population group are necessary to minimise fentanyl‐related harms.
How does supplier CSR performance help to expand exchange relationships with major buyers? The moderating role of supply‐side and demand‐driven uncertainty
Authors: Liu Xiaojin , Kou Ying , Shockley Jeff , Smith Jeffery S. 
Published: October 2021

AbstractMost studies of corporate social responsibility (CSR) performance in a supply chain context have been conducted from the buyer's perspective. Few have paid attention to how suppliers leverage this kind of performance to expand exchange relationships with major customers. From a resource dependence and social exchange perspective, this article specifically examines whether two supplier CSR performance dimensions—environmental and product performance—can serve as a mechanism to expand a supplier's relationships with a smaller number of major buyers, where its increasing exchange dependence often measures this factor. Moreover, these dependent relationships may further develop and change under different conditions of uncertainty. Using large‐scale longitudinal data to test the proposed model, we find empirical evidence that a supplier's environmental and product performance relate positively to greater customer dependence and improved financial performance across diverse sets of industries. However, the findings also reveal that both demand‐driven and supply‐side uncertainty can weaken the effect. Specifically, the positive effect of environmental performance tends to weaken in the face of supply‐side uncertainty, whereas the positive effect of product performance tends to weaken amid demand‐driven uncertainty. Accordingly, we note important nuances and contingencies for suppliers to consider when considering how investments in these CSR performance dimensions affect exchange dependence.
Measuring the water retention curve of rock fragments: A novel repacked core methodology
Authors: Robertson Balin B. , Gillespie Julie D. , Carrick Sam T. , Almond Peter C. , Payne John , Chau Henry W. , Smith Carol M. S. 
Published: October 2021

AbstractWe describe a novel suction plate experiment that uses large, repacked soil cores comprising clasts and a fine‐textured matrix to accurately measure the water retention curve of rock fragments (RFs) of high and low porosity. The method incorporates a suction plate‐core containment system that can be weighed as a unit, to overcome typical core size restrictions. The method relies on analysing the relationship between total core volumetric water content and RF concentration. Cores are packed with a mix of glass and RFs to maintain a uniform volumetric total clast proportion of 30% while RF concentration varies. A constant total clast volume improves accuracy and precision by ensuring the water‐holding characteristics of the matrix varies as little as possible among cores.Highlights
We determine the water retention curve of greywacke‐pumice clasts in large, repacked soil cores.
A suction plate‐core containment system that is weighed as a unit allows large cores to be used.
WRC is determined with cores of varying rock%, but total clast% stays constant by adding glass.
By using the above, the WRC of low and high porosity rocks can be measured precisely.
Family Trouble: Changing (Dis)Orders and Psychotherapeutic Interventions in Uganda
Authors: Vorhölter Julia 
Published: October 2021

AbstractThe recent popularization of psychotherapy in Uganda, while reflecting a global trend, is also a response to the far‐reaching political, economic, and social transformations the country has undergone since 1986. These have caused new forms of stress and uncertainty and triggered desires for new forms of sense‐making and care, particularly among middle‐class Ugandans who are struggling with lifestyle‐related suffering and family conflicts. Psychotherapy in Uganda is intimately, but paradoxically, entangled with neoliberal capitalism. By helping individuals adapt to capitalist modernity, psychotherapists help to reproduce the very system whose ills they are treating. However, they also believe that psychotherapy can produce critical counternarratives and a new form of care that challenges conventional hierarchies, ideologies, and norms. Based on an ethnographic case study of a symposium on family therapy, this article investigates the complex position of Ugandan therapists as mediators of social change and translators of new forms of knowledge.
Tooth loss, dental prostheses use and cognitive performance in older Brazilian adults: The SABE cohort study
Authors: Bof de Andrade Fabiola , de Oliveira Cesar , de Oliveira Duarte Yeda Aparecida , Sabbah Wael , Bernabé Eduardo 
Published: October 2021

AimTo investigate the within‐ and between‐person longitudinal effects of tooth loss and the use of dentures, clinically assessed by dentists, on cognitive decline in a representative sample of community‐dwelling older Brazilian adults.MethodsData came from 1265, 1112 and 1021 individuals aged ≥60 years who participated in the second (2006), third (2010) and fourth (2015) waves, respectively, of the Health, Well‐being and Aging study (SABE). Cognitive performance was evaluated with the abbreviated version of the Mini‐Mental State Examination (MMSE). The number of natural teeth was classified according to three categories: none, 1–19 and ≥20 teeth. The presence of removable full or partial dentures in each dental arch (yes/no) was recorded. Hybrid regression models, adjusted for sociodemographic, behavior and health‐related covariates, were used to estimate the between‐ and within‐person effects of the longitudinal association between cognitive performance and oral health.ResultsParticipants with 1–19 and no teeth had, respectively, 1.15 (95% CI 0.65–1.66) and 1.54 (95% CI 0.99–2.09) units lower MMSE score than those with ≥20 teeth. Denture wearers had 1.54 (95% CI 1.13–1.95) units greater MMSE score than non‐denture wearers, and those who started wearing dentures during the follow up had 0.83 (95% CI 0.21–1.45) units greater MMSE score after the transition.ConclusionOur main findings showed that the use of dental prostheses might be a protective factor for cognitive decline. Geriatr Gerontol Int 2021; 21: 1093–1098.
Thrombomodulin in patients with mild to moderate bleeding tendency
Authors: Mehic Dino , Tolios Alexander , Hofer Stefanie , Ay Cihan , Haslacher Helmuth , Downes Kate , Haimel Matthias , Pabinger Ingrid , Gebhart Johanna 
Published: October 2021

AbstractIntroductionA massive increase of soluble thrombomodulin (sTM) due to variants in the thrombomodulin gene (THBD) has recently been identified as a novel bleeding disorder.AimTo investigate sTM levels and underlying genetic variants as a cause for haemostatic impairment and bleeding in a large number of patients with a mild to moderate bleeding disorder (MBD), including patients with bleeding of unknown cause (BUC).Patients and methodsIn 507 MBD patients, sTM levels, thrombin generation and plasma clot formation were measured and compared to 90 age‐ and sex‐matched healthy controls. In patients, genetic analysis of the THBD gene was performed.ResultsNo difference in sTM levels between patients and controls was found overall (median ([IQR] 5.0 [3.8‐6.3] vs. 5.1 [3.7‐6.4] ng/ml, p = .762), and according to specific diagnoses of MBD or BUC, and high sTM levels (≥95th percentile of healthy controls) were not overrepresented in patients. Soluble TM levels had no impact on bleeding severity or global tests of haemostasis, including thrombin generation or plasma clot formation. In the THBD gene, no known pathogenic or novel disease‐causing variants affecting sTM plasma levels were identified in our patient cohort.ConclusionTM‐associated coagulopathy appears to be rare, as it was not identified in our large cohort of patients with MBD. Soluble TM did not arise as a risk factor for bleeding or altered haemostasis in these patients.
Adaptation of an in‐house PCR for the detection of Helicobacter pylori and the mutations associated with macrolide resistance into ready‐to‐use PCR microwell strips
Authors: Bénéjat Lucie , Ducournau Astrid , Domingues‐Martins Chloé , Lecoeur Mélanie , Blosse Alice , Mégraud Francis , Bessède Emilie , Lehours Philippe 
Published: October 2021

AbstractBackground and ObjectivesThe present study describes the successful adaptation of an in‐house Polymerase Chain Reaction (PCR) for Helicobacter pylori detection coupled with the main mutations associated with resistance to clarithromycin in ready‐to‐use PCR microwell strips.Materials and MethodsThese microwell strips can be used on LightCycler® 480, and are delivered with nine microliters of the reaction mixture dispensed into 8‐well microwell strips. An extraction control PCR targeting the β‐globin household gene is amplified in the same run as H pylori detection.Results and ConclusionThese microwell strips can be stored at −20°C for 1 year and left at room temperature and in the light for up to 4 h with no impact on the PCR results. Microwell strips can also undergo a thaw and refreeze cycle without impacting the PCR results. These PCR microwell strips are available for purchase from Eurogentec.
Identifying local barriers to access to healthcare services in Chile using a communitarian approach
Authors: Núñez Alicia , Manzano Carlos A. 
Published: October 2021

AbstractIntroductionPrevious research has used proxy variables or a unique construct to quantify healthcare access. However, there is a need for a different model that can handle this multivariable problem. This study seeks to develop a way to measure access to the local healthcare system with higher local resolution.MethodsA new survey was developed based on communitarian claims, following a behavioural model and an ontological framework. The survey was used to identify local barriers to healthcare services and the local preferences for priority settings. The results were analysed using multiattribute utility functions and individual weights were assigned by a panel of experts. National and regional indexes of access to healthcare were developed.ResultsThe survey contained seven modules and 104 questions. It was conducted on 1885 participants at 42 rural and 231 urban locations in three regions of Chile. The total disutility of the identified barriers to healthcare access at the national level was low (0.1448; values ranged between 0 and 1, with 1 representing a higher barrier) and was higher in the northern region (0.1467). The barriers associated with the health‐policy component showed the highest disutility value, and specific barriers for each community were identified.ConclusionsThese results have the potential to improve health decision‐making in Chile and can be used to assess the impacts of new health policy reforms. Although this model was tested in Chile, it can be adapted for use in any other country.Patient or Public ContributionParticipants contributed to this study by completing a survey, participating in general talks and receiving brochures with the results obtained from this study.
Framing gender in Mughal South Asia
Authors: Kalb Emma 
Published: October 2021

AbstractResearch on gender in Mughal South Asia has tended to focus either on the nature of the harem and elite female seclusion or, alternately, on constructions of elite masculinity. The first body of literature centers on debates as to the degree to which the harem functioned to limit (elite) women and constrain their political, economic, and social roles. The second analyzes how normative masculinity took shape during different reigns, according to both the preferences of the emperor and his advisors as well as the broader socio‐political context. Taken as a whole, this body of work provides nuanced, contextualized accounts of how gender functioned to shape the lives and/or representations of elite men and women, even as it echoes archival sources in focusing on Mughal elites and tends to be framed primarily in terms of the Persianate or Islamicate world. Recent research suggests not only the value of examining questions of gender in relation to non‐elites, but also the relevance of the household and the family, the influence of the Indic, the relationship of notions of gender to understandings of the body itself, and alternatives to a narrowly defined gender binary.
Diagnostic value of white blood cell parameters for COVID‐19: Is there a role for HFLC and IG?
Authors: Myari Alexandra , Papapetrou Evangelia , Tsaousi Christina 
Published: October 2021

AbstractIntroductionAs the Coronavirus disease 2019 (COVID‐19) pandemic is still ongoing with patients overwhelming healthcare facilities, we aimed to investigate the ability of white blood cell count (WBC) and their subsets, high fluorescence lymphocyte cells (HFLC), immature granulocyte count (IG), and C‐reactive protein (CRP) to aid diagnosis of COVID‐19 during the triage process and as indicators of disease progression to serious and critical condition.MethodsWe collected clinical and laboratory data of patients, suspected COVID‐19 cases, admitted at the emergency department of University General Hospital of Ioannina (Ioannina, Greece). We selected 197 negative and 368 positive cases, confirmed by polymerase chain reaction test for severe acute respiratory syndrome coronavirus 2. COVID‐19 cases were classified into mild, serious, and critical disease. Receiver operating characteristic curve and binary logistic regression analysis were utilized for assessing the diagnosing ability of biomarkers.ResultsWBC, neutrophil count (NEUT), and HFLC can discriminate efficiently negative cases from mild and serious COVID‐19, whereas eosinopenia and basopenia are early indicators of the disease. The combined WBC‐HFLC marker is the best diagnostic marker for both mild (sensitivity: 90.6% and specificity: 64.1%) and serious (sensitivity: 90.3% and specificity: 73.4%) disease. CRP and Lymphocyte count are early indicators of progression to serious disease whereas WBC, NEUT, IG, and neutrophil‐to‐lymphocyte ratio are the best indicators of critical disease.ConclusionLymphopenia is not useful in screening patients with COVID‐19. HFLC is a good diagnostic marker for mild and serious disease either as a single marker or combined with WBC whereas IG is a good indicator of progression to critical disease.
Where Does the Holy Spirit Proceed To?
Authors: Lombardo Nicholas E. 
Published: October 2021

AbstractFollowing suggestions from Karl Rahner and Gilles Emery, this article looks to the economy for answers about where, within the immanent Trinity, the Holy Spirit proceeds to. After discussing the theological legitimacy of the question and drawing some initial conclusions – namely, that the Spirit proceeds from the Father to the Son, and then through the Son back to the Father – it discusses indications in the economy that conflict with these initial conclusions, and then proposes a resolution. It proposes that, by holding the Holy Spirit to be identical with the Spirit's very act of proceeding, and by understanding the Spirit's act of proceeding to be a circular movement from Father to Son and then back to the Father, the conflicting indications of the economy can be resolved.
Long‐term effect of extracorporeal magnetic innervation for post‐prostatectomy urinary incontinence: 1‐year follow‐up
Authors: Terzoni Stefano , Ferrara Paolo , Mora Cristina , Destrebecq Anne 
Published: October 2021

AbstractUrinary incontinence after radical prostatectomy is a common and bothersome problem. Pelvic floor muscle training (PFMT) is supported by strong recommendations in the European guidelines as the first‐choice rehabilitation method. Extracorporeal magnetic innervation (ExMI) has been studied in a previous pilot investigation by our team and seemed useful for shortening the duration of the rehabilitation programme, although patients still need to perform maintenance PFMT regardless of the method chosen for rehabilitation. Very few data exist in literature about its long‐term effects on men; the need for additional evidence therefore remains. To investigate the long‐term effects of ExMI associated with maintenance PFMT, compared to PFMT alone, in maintaining continence after the end of a rehabilitation programme. Follow‐up study on 83 rehabilitated patients (67 PFMT, 16 ExMI). All patients were instructed by a nurse specialist to perform the same maintenance PFMT exercises, based on the literature. Pad‐test was performed by all patients after 3, 6 and 12 months from the end of the rehabilitation programme. As in previously published studies, rehabilitation was defined as leakages <10 g/day based on a literature definition. A mixed effects linear model was used to assess differences between residual leakages over time. Both PFMT and ExMI gave clinically satisfactory results during the whole follow‐up period, without statistically significant differences in the leakages. However, the correlation coefficients suggest that the results are more stable in the PFMT group over time, with less variations in the residual leakages. ExMI can be used during rehabilitation to speed up recovery, but PFMT are still needed for maintenance and provide better results in the long run, even though ExMI also provides satisfactory continence outcomes at follow‐up. Studies on larger samples are needed to confirm these findings.
Using video observation in the family context: The association between camera‐related behaviors and parental sensitivity
Authors: Flameling L. Jacob , Mesman Judi 
Published: October 2021

AbstractResearch on parental sensitivity often relies on video observation of parent–infant dyads. However, to date, no study has assessed both infants’ and parents’ interactions with the camera, and how this relates to parental sensitivity levels. This exploratory study micro‐coded camera‐related behaviors (CRB) by 4‐month olds and their mothers and fathers on a 1‐s time base, and examined the associations between those behaviors and parental sensitivity in 75 Dutch families. While parents’ CRB made up only 0.8% of total interaction time, infants’ made up 12%. Multi‐level time‐series analyses showed that infants’ CRB predicted mothers’. Infants’ CRB predicted fathers’ CRB, and vice versa. Maternal sensitivity was significantly lower when children looked at the camera for over one‐third of total interaction time (Cohen's d = 1.26). These findings indicate further research is required to better understand how video observation might threaten ecological validity.
Final clinical practicum shapes the transition experience and occupational commitment of newly graduated nurses in Europe—A longitudinal study
Authors: Kaihlanen Anu‐Marja , Gluschkoff Kia , Koskinen Sanna , Salminen Leena , Strandell‐Laine Camilla , Fuster Linares Pilar , Sveinsdóttir Herdís , Fatkulina Natalja , Ní Chianáin Linda , Stubner Juliane , Leino‐Kilpi Helena ,   the ProCompNurse Consortium
Published: October 2021

AbstractAimsThe aim of the study was to examine the association between the characteristics of a nursing student’s final clinical practicum and the success of transition of newly graduated nurses (NGNs) in six European countries.DesignA longitudinal design with two data collections points (pre‐ and post‐graduate).MethodsThe data were collected with an online survey between May 2018 and April 2020 from graduating nursing students (n = 1796) in Finland, Germany, Iceland, Ireland, Lithuania and Spain. Altogether, 642 NGNs responded to the second questionnaire 1 year after graduation. Logistic and linear regression analyses were used to examine the associations between five clinical practicum characteristics and three indicators for the success of transition (ease of transition, turnover intentions and occupational commitment). Models were adjusted for demographic and background/workplace factors and professional competence.ResultsSeveral associations were observed between the different clinical practicum characteristics and the indicators for a successful transition. Good pedagogical atmosphere and good supervisory relationship were associated with higher likelihood of an easy transition. Good leadership style of the ward manager, good premises of nursing care on the ward and a good supervisory relationship were associated with higher occupational commitment. No consistent association with turnover intention was found.ConclusionHaving a good final clinical practicum before graduation can contribute to an easier transition experience for newly NGNs and strengthen their commitment to the nursing profession.ImpactThis study adds to the limited existing knowledge about the importance of final clinical practicums in shaping the transition process and occupational commitment of NGNs. Investing in creating a good final practicum experience could help healthcare organizations engage new nursing professionals and thus alleviate the existing shortage of nurses.