bluuebunny/crossref_metadata_2025_split huggingface dataset:
Registration of ‘ND Grano’ durum wheat
Authors: Elias Elias M. , Manthey Frank A. , Kumar Ajay , Salsman Evan 
Published: September 2021

AbstractDurum wheat [Triticum turgidum L. ssp. durum (Desf.)] is mainly used for the production of pasta, couscous, and bulgur. Spring durum wheat cultivar ‘ND Grano’ (Reg. no. CV‐1186, PI 687795) was released in 2017 and is adapted to North Dakota and surrounding regions. It was developed by the durum breeding program at North Dakota State University and released by the North Dakota Agricultural Experiment Station. ND Grano was tested as D09557 in the yield trials and has the pedigree D00752/DH01146. In field trials, ND Grano showed high grain yield potential, disease resistance, excellent end‐use qualities, and low cadmium uptake. Based on data from 34 location‐years of testing in the Uniform Regional Durum Nursery, the average grain yield of ND Grano was 4,008 kg ha–1, compared with 3,867 kg ha–1 for ‘Divide’ and 3,978 kg ha–1 for ‘Joppa’. ND Grano has very strong dough mixing characteristics and a high gluten index. Fusarium head blight (FHB) tolerance of ND Grano is similar to Divide. ND Grano is also resistant to predominant races of stem rust.
SGLT2‐Inhibition reverts urinary peptide changes associated with severe COVID‐19: An in‐silico proof‐of‐principle of proteomics‐based drug repurposing
Authors: Latosinska Agnieszka , Siwy Justyna , Cherney David Z. , Perkins Bruce A. , Mischak Harald , Beige Joachim 
Published: September 2021

AbstractSevere COVID‐19 is reflected by significant changes in urine peptides. Based on this observation, a clinical test predicting COVID‐19 severity, CoV50, was developed and registered as in vitro diagnostic in Germany. We have hypothesized that molecular changes displayed by CoV50, likely reflective of endothelial damage, may be reversed by specific drugs. Such an impact by a drug could indicate potential benefits in the context of COVID‐19. To test this hypothesis, urinary peptide data from patients without COVID‐19 prior to and after drug treatment were collected from the human urinary proteome database. The drugs chosen were selected based on availability of sufficient number of participants in the dataset (n > 20) and potential value of drug therapies in the treatment of COVID‐19 based on reports in the literature. In these participants without COVID‐19, spironolactone did not demonstrate a significant impact on CoV50 scoring. Empagliflozin treatment resulted in a significant change in CoV50 scoring, indicative of a potential therapeutic benefit. The study serves as a proof‐of‐principle for a drug repurposing approach based on human urinary peptide signatures. The results support the initiation of a randomized control trial testing a potential positive effect of empagliflozin for severe COVID‐19, possibly via endothelial protective mechanisms.
Potato plant variety affects the performance and oviposition preference of Phthorimaea operculella Zeller (Lepidoptera: Gelechiidae)
Authors: Zhang Mengdi , Yan Junjie , Ali Abid , Gao Yulin 
Published: September 2021

AbstractBACKGROUNDDamage by the potato tuber moth Phthorimaea operculella is one of the major constraints to commercial production of potato in many areas of the world. To promote effective pest management practices for P. operculella based on host plant, larval and adult performance of P. operculella fed on Lishu 6, Hezuo 88, Yunshu 304, and Qingshu 9 potato varieties was compared by examining their survival rate, larval feeding, pupal weight, and oviposition preference.RESULTSCompared with larvae fed on the other three potato plants, those fed on Lishu 6 exhibited the highest survival rate, with almost 61.67% developing to the adult stage. Females also preferred to lay their eggs on Lishu 6 over Hezuo 88, Yunshu 304 and Qingshu 9; and the weight of P. operculella pupa on Lishu 6 plant (0.0085 g) was significantly heavier than that of on others, especially on Qingshu 9 (0.0062 g). Moreover, first instar larvae fed on Lishu 6 showed host preference to Qingshu 9.CONCLUSIONThis study demonstrated that Lishu 6 is susceptible to P. operculella, and Qingshu 9 is not relatively susceptible to P. operculella, which suggested that the P. operculella feeding responses to dominant potato varieties in China is different. This variation can be applied for the potato breeding and pest management practice. © 2021 Society of Chemical Industry.
Event‐based output feedback control of periodic systems: A piecewise impulsive method
Authors: Yang Liu , Gao Yabin , Feng Zhiguang , Wu Ligang 
Published: September 2021

AbstractIn this article, an event‐triggered control with periodic time‐varying parameters is designed to stabilize a class of periodic systems with exogenous disturbances in a network environment. The continuous‐time periodic system is approximated by some linear subsystems with finite‐number constant matrices based on a piecewise method. It can thus reduce the complexity of theoretical analysis. To tackle the reduction of unnecessary data transmission between the sensor (or controller) and the controller (or actuator), new event‐triggering mechanisms are designed via output feedback. Special parameters are designed to eliminate Zeno behavior, and the minimum triggering interval is obtained according to the designed condition. Then, an event‐triggered periodic piecewise system is modeled as an impulsive periodic piecewise system. The bounded stability, as well as the performance of the impulsive periodic piecewise system, are analyzed. Furthermore, the gains of the event‐triggered controller are obtained by a method of variable substitution. Finally, the validity of the proposed control is demonstrated by an application example.
Chemotaxis of Oil Droplets and Their Phase Transition to Aggregates with Membrane Structures in Surfactant Solution Containing Metal Salts
Authors: Nakayama Sepia , Kojima Tomoya , Kaburagi Mari , Kikuchi Takanori , Asakura Kouichi , Banno Taisuke 
Published: September 2021

AbstractThe movement of supramolecular self‐assemblies has been induced by the application of external stimuli that cause a shift to non‐equilibrium conditions. However, few supramolecular chemical systems exist in which multiple different functions are associated with movement. Herein, we observed multiple phase transition of micrometer‐sized lauronitrile oil droplets in a solution of cationic surfactants with aniline skeletons in the presence of metal ions. These dynamics include tactic motion and subsequent formation of aggregates with membrane structures, in a linear‐type channel. These dynamic behaviors result from variations in the interfacial tension at the droplet surface and the chemical compositions owing to the interactions between system components. The current findings may provide a methodology for designing molecular systems in which multi‐step phase transitions of supramolecular self‐assemblies are coupled to movement in non‐equilibrium conditions.
Corynoline protects lipopolysaccharide‐induced mastitis through regulating AKT/GSK3β/Nrf2 signaling pathway
Authors: Wu Yunhao , He Tao , Fu Yunhe , Chen Jie 
Published: September 2021

AbstractInflammation has been known to be involved in the pathogenesis of mastitis. And anti‐inflammatory agent is proposed to be a possible efficient therapeutic strategy for mastitis. Corynoline, a bioactive compound extracted from Corydalis bungeana Turcz., has been reported to have anti‐inflammatory effect. However, whether corynoline has protective effect against mastitis remains unclear. The aim of this study was to evaluate the protective effect of corynoline on LPS‐induced mastitis in mice. Inflammatory cytokine production was measured by ELISA. The proteins of signaling pathways were detected by western blot analysis. The results showed that treatment of corynoline at the doses of 15, 30, and 60 mg/kg significantly attenuated LPS‐induced pathological damage of mammary tissues. Corynoline also ameliorated LPS‐induced MPO activity, MDA content, and inflammatory cytokine TNF‐α and IL‐1β production in mammary tissues. LPS‐induced NF‐κB activation was inhibited by corynoline. Furthermore, our results showed corynoline significantly increased the expression of Nrf2 and the phosphorylation levels of AKT and GSK3β. In conclusion, our results indicated that corynoline protected against LPS‐induced mastitis through regulating AKT/GSK3β/Nrf2 signaling pathway, which subsequently led to the inhibition of NF‐κB and inflammatory response.
An approach for management modeling of a tropical wetland
Authors: López‐Calatayud Nereida Coromoto , Márquez‐Romance Adriana Mercedes , Guevara‐Pérez Edilberto , Buroz‐Castillo Eduardo 
Published: September 2021

AbstractThis article has proposed an approach for management modeling of a tropical wetland. The model is based on the combination of the components and criteria established in the 4th Strategic Plan (SP4) 2016–2024 of the Ramsar Convention on Wetlands with Bloom's Taxonomy. The management modeling of a tropical wetland consists of the formulation of a multiple criteria matrix of wetland management strategic plan (WMSP) for 18 Latin countries based an integral wetland management model index (WMMI‐integral) associated with Bloom's Taxonomy. The WMMI‐integral is categorized into five levels that include knowledge, comprehension, application, evaluation, and creation, which are influenced by the implementation in the Latin‐countries of targets linked to the goals of SP4. The results are fitting a multiple linear regression model to describe the relationship between WMMI‐Integral and five parameters. The proposed wetland management model constitutes a tool to contribute a decision for assessing sustainability by coupling an approach that considers wetland management components and attributes for wetland inventory, diagnosis, assessment, creation.
The Workgroup Serrated Polyps and Polyposis (WASP) classification for optical diagnosis of colorectal diminutive polyps with iScan and the impact of the revised World Health Organization (WHO) criteria
Authors: Soons Elsa , Bisseling Tanya M. , van der Post Rachel S. , Nagtegaal Iris D. , Hazewinkel Yark , van Kouwen Mariette C. A. , Siersema Peter D. 
Published: September 2021

AbstractBackground and aimsThe Workgroup Serrated Polyps and Polyposis (WASP) developed criteria for optical diagnosis of colorectal polyps. The aims of this study were: (1) to improve optical diagnosis of diminutive colorectal polyps, especially SSLs, after training endoscopists in applying WASP criteria on videos of polyps obtained with iScan and (2) to evaluate if the WASP criteria are still useful when polyps are pathologically revised according to the World Health Organization (WHO) 2019 criteria.MethodsTwenty‐one endoscopists participated in a training session and predicted polyp histology on 30 videos of diminutive polyps, before and after training (T0 and T1). After three months, they scored another 30 videos (T2). Primary outcome was overall diagnostic accuracy (DA) at T0, T1 and T2. Polyps were histopathologically classified according to the WHO 2010 and 2019 criteria.ResultsOverall DA (both diminutive adenomas and SSLs) significantly improved from 0.58 (95% CI 0.55–0.62) at T0 to 0.63 (95% CI 0.60–0.66, p = 0.004) at T1. For SSLs, DA did not change with 0.51 (95% CI 0.46–0.56) at T0 and 0.55 (95% CI 0.49–0.60, p = 0.119) at T1. After three months, overall DA was 0.58 (95% CI 0.54–0.62, p = 0.787, relative to T0) while DA for SSLs was 0.48 (95% CI 0.42–0.55, p = 0.520) at T2. After pathological revision according to the WHO 2019 criteria, DA of all polyps significantly changed at all time points.ConclusionA training session in applying WASP criteria on endoscopic videos made with iScan did not improve endoscopists' long‐term ability to optically diagnose diminutive polyps. The change of DA following polyp revision according to the revised WHO 2019 criteria suggests that the WASP classification may need revision.
Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases
Authors: Salminen Antero , Kaarniranta Kai , Kauppinen Anu 
Published: September 2021

Abstract
Background
The insulin/IGF-1 signaling pathway has a major role in the regulation of longevity both in Caenorhabditis elegans and mammalian species, i.e., reduced activity of this pathway extends lifespan, whereas increased activity accelerates the aging process. The insulin/IGF-1 pathway controls protein and energy metabolism as well as the proliferation and differentiation of insulin/IGF-1-responsive cells. Insulin/IGF-1 signaling also regulates the functions of the innate and adaptive immune systems. The purpose of this review was to elucidate whether insulin/IGF-1 signaling is linked to immunosuppressive STAT3 signaling which is known to promote the aging process.

Methods
Original and review articles encompassing the connections between insulin/IGF-1 and STAT3 signaling were examined from major databases including Pubmed, Scopus, and Google Scholar.

Results
The activation of insulin/IGF-1 receptors stimulates STAT3 signaling through the JAK and AKT-driven signaling pathways. STAT3 signaling is a major activator of immunosuppressive cells which are able to counteract the chronic low-grade inflammation associated with the aging process. However, the activation of STAT3 signaling stimulates a negative feedback response through the induction of SOCS factors which not only inhibit the activity of insulin/IGF-1 receptors but also that of many cytokine receptors. The inhibition of insulin/IGF-1 signaling evokes insulin resistance, a condition known to be increased with aging. STAT3 signaling also triggers the senescence of both non-immune and immune cells, especially through the activation of p53 signaling.

Conclusions
Given that cellular senescence, inflammaging, and counteracting immune suppression increase with aging, this might explain why excessive insulin/IGF-1 signaling promotes the aging process.
Sex-dependent effects of amyloid precursor-like protein 2 in the SOD1-G37R transgenic mouse model of MND
Authors: Truong Phan H. , Crouch Peter J. , Hilton James B. W. , McLean Catriona A. , Cappai Roberto , Ciccotosto Giuseppe D. 
Published: September 2021

AbstractMotor neurone disease (MND) is a neurodegenerative disorder characterised by progressive destruction of motor neurons, muscle paralysis and death. The amyloid precursor protein (APP) is highly expressed in the central nervous system and has been shown to modulate disease outcomes in MND. APP is part of a gene family that includes the amyloid precursor-like protein 1 (APLP1) and 2 (APLP2) genes. In the present study, we investigated the role of APLP2 in MND through the examination of human spinal cord tissue and by crossing APLP2 knockout mice with the superoxide dismutase 1 (SOD1-G37R) transgenic mouse model of MND. We found the expression of APLP2 is elevated in the spinal cord from human cases of MND and that this feature of the human disease is reproduced in SOD1-G37R mice at the End-stage of their MND-like phenotype progression. APLP2 deletion in SOD1-G37R mice significantly delayed disease progression and increased the survival of female SOD1-G37R mice. Molecular and biochemical analysis showed female SOD1-G37R:APLP2−/− mice displayed improved innervation of the neuromuscular junction, ameliorated atrophy of muscle fibres with increased APP protein expression levels in the gastrocnemius muscle. These results indicate a sex-dependent role for APLP2 in mutant SOD1-mediated MND and further support the APP family as a potential target for further investigation into the cause and regulation of MND.
Optimization of a protocol for contrast-enhanced four-dimensional computed tomography imaging of thoracic tumors using minimal contrast agent
Authors: Dai Hongya , Yang Dingqiang , Chen Lu , Zhou Yibing , Wen Xiaojing , Sun Jianguo , Li Guanghui 
Published: September 2021

Abstract
Purpose
The accuracy of target delineation for node-positive thoracic tumors is dependent on both four-dimensional computed tomography (4D-CT) and contrast-enhanced three-dimensional (3D)-CT images; these scans enable the motion visualization of tumors and delineate the nodal areas. Combining the two techniques would be more effective; however, currently, there is no standard protocol for the contrast media injection parameters for contrast-enhanced 4D-CT (CE-4D-CT) scans because of its long scan durations and complexity. Thus, we aimed to perform quantitative and qualitative assessments of the image quality of single contrast-enhanced 4D-CT scans to simplify this process and improve the accuracy of target delineation in order to replace the standard clinical modality involved in administering radiotherapy for thoracic tumors.

Methods
Ninety consecutive patients with thoracic tumors were randomly and parallelly assigned to one of nine subgroups subjected to CE-4D-CT scans with the administration of contrast agent volume equal to the patient’s weight but different flow rate and scan delay time (protocol A1: flow rate of 2.0 ml/s, delay time of 15 s; A2: 2.0 ml/s, 20 s; A3: 2.0 ml/s, 25 s; B1: 2.5 ml/s, 15 s; B2: 2.5 ml/s, 20 s; B3: 2.5 ml/s, 25 s; C1: 3.0 ml/s, 15 s; C2: 3.0 ml/s, 20 s; C3: 3.0 ml/s, 25 s). The Hounsfield unit (HU) values of the thoracic aorta, pulmonary artery stem, pulmonary veins, carotid artery, and jugular vein were acquired for each protocol. Both quantitative and qualitative image analysis and delineation acceptability were assessed.

Results
The results revealed significant differences among the nine protocols. Enhancement of the vascular structures in mediastinal and perihilar regions was more effective with protocol A1 or A2; however, when interested in the region of superior mediastinum and supraclavicular fossa, protocol C2 or C3 is recommended.

Conclusion
Qualitatively acceptable enhancement on contrast-enhanced 4D-CT images of thoracic tumors can be obtained by varying the flow rate and delay time when minimal contrast agent is used.
On the probability of lymph node negativity in pN0-staged prostate cancer—a theoretically derived rule of thumb for adjuvant needs
Authors: Paulsen Frank , Bedke Jens , Wegener Daniel , Marzec Jolanta , Martus Peter , Nann Dominik , Stenzl Arnulf , Zips Daniel , Müller Arndt-Christian 
Published: September 2021

Abstract
Purpose
The extent of lymphadenectomy and clinical features influence the risk of occult nodes in node-negative prostate cancer. We derived a simple estimation model for the negative predictive value (npv) of histopathologically node-negative prostate cancer patients (pN0) to guide adjuvant treatment.

Methods
Approximations of sensitivities in detecting lymph node metastasis from current publications depending on the number of removed lymph nodes were used for a theoretical deduction of a simplified formulation of npv assuming a false node positivity of 0.

Results
A theoretical formula of npv = p(N0IpN0) = (100 − prevalence) / (100 − sensitivity × prevalence) was calculated (sensitivity and preoperative prevalence in %). Depending on the number of removed lymph nodes (nLN), the sensitivity of pN0-staged prostate cancer was derived for three sensitivity levels accordingly: sensitivity = f(nLN) = 9 × nLN /100 for 0 ≤ nLN ≤ 8 and f(nLN) = (nLN + 70) /100 for 9 ≤ nLN ≤ 29 and f(nLN) = 1 for nLN ≥ 30.

Conclusion
We developed a theoretical formula for estimation of the npv in pN0-staged prostate cancer patients. It is a sine qua non to use the formula in a clinically experienced context before deciding to electively irradiate pelvic lymph nodes or to intensify adjuvant systemic treatment.
Non-negatively curved GKM orbifolds
Authors: Goertsches Oliver , Wiemeler Michael 
Published: September 2021

AbstractIn this paper we study non-negatively curved and rationally elliptic GKM$$_4$$

4

manifolds and orbifolds. We show that their rational cohomology rings are isomorphic to the rational cohomology of certain model orbifolds. These models are quotients of isometric actions of finite groups on non-negatively curved torus orbifolds. Moreover, we give a simplified proof of a characterisation of products of simplices among orbit spaces of locally standard torus manifolds. This characterisation was originally proved in Wiemeler (J Lond Math Soc 91(3): 667–692, 2015) and was used there to obtain a classification of non-negatively curved torus manifolds.
Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra
Authors: Jarusintanakorn Salinthip , Phechkrajang Chutima , Khongkaew Putthiporn , Mastrobattista Enrico , Yamabhai Montarop 
Published: September 2021

AbstractAntibody titer and viable cell density (VCD) are two important parameters that need to be closely monitored during the process of cell line development and manufacturing of therapeutic antibodies. Typically, determination of each parameter requires 10–100 μL of supernatant sample, which is not suitable for small scale cultivation. In this study, we demonstrated that as low as 2 μL of culture supernatants were sufficient for the analysis using UV-Vis spectrum assisted with partial least squares (PLS) model. The results indicated that the optimal PLS models could be used to predict antibody titer and VCD with the linear relationship between reference values and predicted values at R2 values ranging from 0.8 to > 0.9 in supernatant samples obtained from four different single clones and in polyclones that were cultured in various selection stringencies. Then, the percentage of cell viability and productivity were predicted from a set of samples of polyclones. The results indicated that while all predicted % cell viability were very similar to the actual value at RSEP value of 6.7 and R2 of 0.8908, the predicted productivity from 14 of 18 samples were closed to the reference measurements at RSEP value of 22.4 and R2 of 0.8522. These results indicated that UV-Vis combined with PLS has potential to be used for monitoring antibody titer, VCD, and % cell viability for both online and off-line therapeutic production process.
Graphical abstract