bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resident Exposure to Aesthetic Surgical and Nonsurgical Procedures During Canadian Residency Program Training
Authors: Quong Whitney L , Shih Jessica G , Knox Aaron D C , Zhygan Nick , Fish Joel S , Courtemanche Douglas J , Brown Mitchell H 
Published: February 2021

Abstract
North American residency programs are transitioning to competency-based medical education (CBME) to standardize training programs, and to ensure competency of residents upon graduation. At the centre of assessment in CBME are specific surgical procedures, or procedural competencies, that trainees must be able to perform. A study previously defined 31 procedural competencies for aesthetic surgery. In this transition period, understanding current educational trends in resident exposure to these aesthetic procedures is necessary.
The aim of this study was to characterize aesthetic procedures performed by Canadian plastic surgery residents during training, as well as to describe resident performance confidence levels and degree of resident involvement during those procedures.
Case logs were retrieved from all 10 English-language plastic surgery programs. All aesthetic procedures were identified, and coded according to previously defined core procedural competencies (CPCs) in the aesthetic domain of plastic surgery. Data extracted from each log included the procedure, training program, resident academic year, resident procedural role, and personal competence.
From July 2004 to June 2014, 6113 aesthetic procedures were logged by 55 graduating residents. Breast augmentation, mastopexy, and abdominoplasty were the most commonly performed CPCs, and residents report high levels of competence and surgical role in these procedures. Facial procedures, in particular rhinoplasty, as well as nonsurgical CPCs are associated with low exposure and personal competence levels.
Canadian plastic surgery residents are exposed to most of the core aesthetic procedural competencies, but the range of procedures performed is variable. With the implementation of CBME, consideration should be given to supplementation where gaps may exist in aesthetic case exposure.
DDX21 interacts with nuclear AGO2 and regulates the alternative splicing of SMN2
Authors: Gong Mengting , Zhang Xi , Wang Yaru , Mao Guiyan , Ou Yangqi , Wei Chenxi , Hu Xiang , Xiang Shuanglin 
Published: February 2021

ABSTRACT
AGO2 is the only member of mammalian Ago protein family that possesses the catalytic activity and plays a central role in gene silencing. Recently researches reported that multiple gene silencing factors, including AGO2, function in the nuclei. The molecular mechanisms of the gene silencing factors functioning in nuclei are conducive to comprehend the roles of gene silencing in pretranslational regulation of gene expression. Here, we report that AGO2 interacts with DDX21 indirectly in an RNA-dependent manner by Co-IP and GST-Pulldown assays and the 2 proteins present nuclei foci in the immunofluorescence experiments. We found that DDX21 up-regulated the protein level of AGO2 and participated in target gene, SNM2, alternative splicing involved in AGO2 by the indirect interaction with AGO2, which produced different transcripts of SMN2 in discrepant expression level. This study laid important experiment foundation for the further analysis of the nuclear functions of gene silencing components.
Contribution of structural accessibility to the cooperative relationship of TF-lncRNA in myopia
Authors: Wang Hong , Li Jing , Wang Siyu , Lu Xiaoyan , Zhang Guosi , Zhuang Youyuan , Li Liansheng , Wang Wencan , Lin Peng , Chen Chong , Wang Hao , Chen Qi , Jiang Yongshuai , Qu Jia , Xu Liangde 
Published: February 2021

Abstract
Transcriptional regulation is associated with complicated mechanisms including multiple molecular interactions and collaborative drive. Long noncoding RNAs (lncRNAs) have highly structured characteristics and play vital roles in the regulation of transcription in organisms. However, the specific contributions of conformation feature and underlying molecular mechanisms are still unclear. In the present paper, a hypothesis regarding molecular structure effect is presented, which proposes that lncRNAs fold into a complex spatial architecture and act as a skeleton to recruit transcription factors (TF) targeted binding, and which is involved in cooperative regulation. A candidate set of TF-lncRNA coregulation was constructed, and it was found that structural accessibility affected molecular binding force. In addition, transcription factor binding site (TFBS) regions of myopia-related lncRNA transcripts were disturbed, and it was discovered that base mutations affected the occurrence of significant molecular allosteric changes in important elements and variable splicing regions, mediating the onset and development of myopia. The results originated from structureomics and interactionomics and created conditions for systematic research on the mechanisms of structure-mediated TF-lncRNA coregulation in transcriptional regulation. Finally, these findings will help further the understanding of key regulatory roles of molecular allostery in cell physiological and pathological processes.
Long-term results of thoracoscopic ablation of paroxysmal atrial fibrillation: is the glass half full or half empty?
Authors: Belluschi Igor , Lapenna Elisabetta , Carino Davide , Trumello Cinzia , Cireddu Manuela , Ruggeri Stefania , Schiavi Davide , Monaco Fabrizio , Pozzoli Alberto , Agricola Eustachio , Alfieri Ottavio , De Bonis Michele , Benussi Stefano 
Published: February 2021

Abstract

OBJECTIVES
Previous series showed the outcomes of thoracoscopic ablation of stand-alone symptomatic paroxysmal atrial fibrillation (AF) for up to 7 years of follow-up. The goal of this study was to assess the long-term durability of surgical pulmonary vein isolation (PVI) beyond 7 years.

METHODS
Fifty consecutive patients {mean age 55 [standard deviation (SD): 11.2] years, previous catheter ablation in 56%, left ventricular ejection fraction 60% (SD: 4.6), left atrium volume 65 ml (SD: 17)} with stand-alone symptomatic paroxysmal AF underwent PVI through bilateral thoracoscopy ablation between 2005 and 2014. The CHA2DS2-VASc score was ≥2 in 12 patients (24%).

RESULTS
No hospital deaths occurred. At hospital discharge all patients but 1 (2%) were in sinus rhythm (SR). Follow-up was 100% complete [mean 8.4 years (SD: 2.3), max 15]. The 8-year cumulative incidence function of AF recurrence, with death as a competing risk, on or off class I/III antiarrhythmic drugs (AADs)/electrocardioversion/re-transcatheter ablation (TCA) was 20% (SD: 5; 95% confidence interval: 10, 32); and off class I/III AADs/electrocardioversion/re-TCA was 52% (SD: 7; 95% confidence interval: 0.83, 8.02). At 8 years, the predicted prevalence of patients in SR was 87% and 53% were off class I/III AADs/electrocardioversion/re-TCA. The recurrent arrhythmia was AF in all patients except 2, who had atypical atrial flutter (4%). No predictors of AF recurrence were identified. At the last follow-up, 76% of the patients showed European Heart Rhythm Association class I. No strokes or thromboembolic events were documented and 76% of the subjects were off anticoagulation therapy.

CONCLUSIONS
Despite a considerable AF recurrence rate, our single-centre, long-term outcome of surgical PVI showed encouraging data, with the majority of patients remaining in SR, although many of them were on antiarrhythmic therapy.
The management of secondary mitral regurgitation in patients with heart failure: a joint position statement from the Heart Failure Association (HFA), European Association of Cardiovascular Imaging (EACVI), European Heart Rhythm Association (EHRA), and European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC
Authors: Coats Andrew J S , Anker Stefan D , Baumbach Andreas , Alfieri Ottavio , von Bardeleben Ralph Stephan , Bauersachs Johann , Bax Jeroen J , Boveda Serge , Čelutkienė Jelena , Cleland John G , Dagres Nikolaos , Deneke Thomas , Farmakis Dimitrios , Filippatos Gerasimos , Hausleiter Jörg , Hindricks Gerhard , Jankowska Ewa A , Lainscak Mitja , Leclercq Christoph , Lund Lars H , McDonagh Theresa , Mehra Mandeep R , Metra Marco , Mewton Nathan , Mueller Christian , Mullens Wilfried , Muneretto Claudio , Obadia Jean-Francois , Ponikowski Piotr , Praz Fabien , Rudolph Volker , Ruschitzka Frank , Vahanian Alec , Windecker Stephan , Zamorano Jose Luis , Edvardsen Thor , Heidbuchel Hein , Seferovic Petar M , Prendergast Bernard 
Published: February 2021

Abstract
Secondary (or functional) mitral regurgitation (SMR) occurs frequently in chronic heart failure (HF) with reduced left ventricular (LV) ejection fraction, resulting from LV remodelling that prevents coaptation of the valve leaflets. Secondary mitral regurgitation contributes to progression of the symptoms and signs of HF and confers worse prognosis. The management of HF patients with SMR is complex and requires timely referral to a multidisciplinary Heart Team. Optimization of pharmacological and device therapy according to guideline recommendations is crucial. Further management requires careful clinical and imaging assessment, addressing the anatomical and functional features of the mitral valve and left ventricle, overall HF status, and relevant comorbidities. Evidence concerning surgical correction of SMR is sparse and it is doubtful whether this approach improves prognosis. Transcatheter repair has emerged as a promising alternative, but the conflicting results of current randomized trials require careful interpretation. This collaborative position statement, developed by four key associations of the European Society of Cardiology—the Heart Failure Association (HFA), European Association of Percutaneous Cardiovascular Interventions (EAPCI), European Association of Cardiovascular Imaging (EACVI), and European Heart Rhythm Association (EHRA)—presents an updated practical approach to the evaluation and management of patients with HF and SMR based upon a Heart Team approach.
The draft genome sequence of the grove snail Cepaea nemoralis
Authors: Saenko Suzanne V , Groenenberg Dick S J , Davison Angus , Schilthuizen Menno 
Published: February 2021

Abstract
Studies on the shell color and banding polymorphism of the grove snail Cepaea nemoralis and the sister taxon Cepaea hortensis have provided compelling evidence for the fundamental role of natural selection in promoting and maintaining intraspecific variation. More recently, Cepaea has been the focus of citizen science projects on shell color evolution in relation to climate change and urbanization. C. nemoralis is particularly useful for studies on the genetics of shell polymorphism and the evolution of “supergenes,” as well as evo-devo studies of shell biomineralization, because it is relatively easily maintained in captivity. However, an absence of genomic resources for C. nemoralis has generally hindered detailed genetic and molecular investigations. We therefore generated ∼23× coverage long-read data for the ∼3.5 Gb genome, and produced a draft assembly composed of 28,537 contigs with the N50 length of 333 kb. Genome completeness, estimated by BUSCO using the metazoa dataset, was 91%. Repetitive regions cover over 77% of the genome. A total of 43,519 protein-coding genes were predicted in the assembled genome, and 97.3% of these were functionally annotated from either sequence homology or protein signature searches. This first assembled and annotated genome sequence for a helicoid snail, a large group that includes edible species, agricultural pests, and parasite hosts, will be a core resource for identifying the loci that determine the shell polymorphism, as well as in a wide range of analyses in evolutionary and developmental biology, and snail biology in general.
On Spectral Properties of Compact Toeplitz Operators on Bergman Space with Logarithmically Decaying Symbol and Applications to Banded Matrices
Authors: Koïta Mahamet , Kupin Stanislas , Naboko Sergey , Touré Belco 
Published: February 2021

Abstract
Let $L^2({{\mathbb{D}}})$ be the space of measurable square-summable functions on the unit disk. Let $L^2_a({{\mathbb{D}}})$ be the Bergman space, that is, the (closed) subspace of analytic functions in $L^2({{\mathbb{D}}})$. $P_+$ stays for the orthogonal projection going from $L^2({{\mathbb{D}}})$ to $L^2_a({{\mathbb{D}}})$. For a function $\varphi \in L^\infty ({{\mathbb{D}}})$, the Toeplitz operator $T_\varphi : L^2_a({{\mathbb{D}}})\to L^2_a({{\mathbb{D}}})$ is defined as $$\begin{align*} & T_\varphi f=P_+\varphi f, \quad f\in L^2_a({{\mathbb{D}}}). \end{align*}$$The main result of this article are spectral asymptotics for singular (or eigen-) values of compact Toeplitz operators with logarithmically decaying symbols, that is, $$\begin{align*} & \varphi(z)=\varphi_1(e^{i\theta})\, (1+\log(1/(1-r)))^{-\gamma},\quad \gamma&gt;0, \end{align*}$$where $z=re^{i\theta }$ and $\varphi _1$ is a continuous (or piece-wise continuous) function on the unit circle. The result is applied to the spectral analysis of banded (including Jacobi) matrices.
The Determinants of Uncertainty in International Relations
Authors: Kaplow Jeffrey M , Gartzke Erik 
Published: February 2021

Abstract
Uncertainty about military power is widely considered an important determinant of international conflict, but research in international relations provides relatively little guidance about the origins of uncertainty. What factors influence the validity of actors’ assessments of military capabilities? When would one expect uncertainty about military capabilities to be particularly high, or especially low? We examine a series of factors capable of explaining the sources of uncertainty in international relations, positing that the uncertainty of assessments is a function of both characteristics of the state being assessed and the overall strategic environment. We test our theory using new measures of uncertainty that we derive from analyzing publicly available estimates of national military capabilities. Our findings offer a novel set of implications both for research that relies on uncertainty as a key cause of conflict and for policymakers faced with evaluating foreign military assessments.
When Disasters Hit Civil Wars: Natural Resource Exploitation and Rebel Group Resilience
Authors: Tominaga Yasutaka , Lee Chia-yi 
Published: February 2021

AbstractExisting literature on the relationship between natural disasters and conflicts provides mixed findings. In this article, we argue that whether natural disasters hurt rebel group resilience depends on their funding source and the mode of resource extraction. Rebel groups that obtain their funding from natural resources are more susceptible to natural disasters because this funding source could be easily disrupted by rapid-onset disasters. How rebel groups exploit natural resource wealth also conditions the effect of natural disasters on rebel group resilience. Rebel groups that depend on extorting resource production, despite having a seemingly stable revenue stream, are more likely to face funding cuts after a severe natural disaster. In contrast, rebel groups that rely on smuggling natural resources, due to a higher level of flexibility and mobility, are more likely to survive natural disasters. We test our arguments using data on armed groups, natural disasters, and rebel contraband, and the results of the logit models with interaction terms support our hypotheses. Our findings bridge the environmental conflict literature and the resource curse literature, and offer important policy implications.
Comparison of Narrow-angle and Wide-angle Digital Breast Tomosynthesis Systems in Clinical Practice
Authors: Winter Andrea M , Moy Linda , Gao Yiming , Bennett Debbie L 
Published: February 2021

AbstractDigital breast tomosynthesis (DBT) is a pseudo 3D mammography imaging technique that has become widespread since gaining Food and Drug Administration approval in 2011. With this technology, a variable number of tomosynthesis projection images are obtained over an angular range between 15° and 50° for currently available clinical DBT systems. The angular range impacts various aspects of clinical imaging, such as radiation dose, scan time, and image quality, including visualization of calcifications, masses, and architectural distortion. This review presents an overview of the differences between narrow- and wide-angle DBT systems, with an emphasis on their applications in clinical practice. Comparison examples of patients imaged on both narrow- and wide-angle DBT systems illustrate these differences. Understanding the potential variable appearance of imaging findings with narrow- and wide-angle DBT systems is important for radiologists, particularly when comparison images have been obtained on a different DBT system. Furthermore, knowledge about the comparative strengths and limitations of DBT systems is needed for appropriate equipment selection.
Pyrethroid Exposure Reduces Growth and Development of Monarch Butterfly (Lepidoptera: Nymphalidae) Caterpillars
Authors: Krueger Annie J , Hanford Kathryn , Weissling Thomas J , Vélez Ana M , Anderson Troy D 
Published: February 2021

Abstract
Insecticide exposure has been identified as a contributing stressor to the decline in the North American monarch butterfly Danaus plexippus L. (Lepidoptera: Nymphalidae) population. Monarch toxicity data are currently limited and available data focuses on lethal endpoints. This study examined the 72-h toxicity of two pyrethroid insecticides, bifenthrin and β-cyfluthrin, and their effects on growth and diet consumption. The toxicity of bifenthrin to caterpillars was lower than β-cyfluthrin after 72 h. Survival was the most sensitive endpoint for bifenthrin, but diet consumption and caterpillar growth were significantly reduced at sublethal levels of β-cyfluthrin. Using AgDRIFT spray drift assessment, the aerial application of bifenthrin or β-cyfluthrin is predicted to pose the greatest risk to fifth-instar caterpillars, with lethal insecticide deposition up to 28 m for bifenthrin and up to 23 m for β-cyfluthrin from treated edges of fields. Low boom ground applications are predicted to reduce distances of lethal insecticide exposure to 2 m from the treated field edge for bifenthrin and β-cyfluthrin. Growth and survival of fifth-instar monarch caterpillars developing within the margins of a treated field may be significantly impacted following foliar applications of bifenthrin or β-cyfluthrin. These findings provide evidence that pyrethroid insecticides commonly used for soybean pest control are a potential risk to monarch caterpillars in agricultural landscapes.
The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy
Authors: Bieniek Kevin F , Cairns Nigel J , Crary John F , Dickson Dennis W , Folkerth Rebecca D , Keene C Dirk , Litvan Irene , Perl Daniel P , Stein Thor D , Vonsattel Jean-Paul , Stewart William , Dams-O’Connor Kristen , Gordon Wayne A , Tripodis Yorghos , Alvarez Victor E , Mez Jesse , Alosco Michael L , McKee Ann C ,   the TBI/CTE Research Group, Babcock Debra , Bellgowan Patrick , Crane Paul , Edlow Brian , Huber Bertrand Russ , Kiernan Patrick , Koroshetz Walter 
Published: February 2021

Abstract
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder associated with exposure to head trauma. In 2015, a panel of neuropathologists funded by the NINDS/NIBIB defined preliminary consensus neuropathological criteria for CTE, including the pathognomonic lesion of CTE as “an accumulation of abnormal hyperphosphorylated tau (p-tau) in neurons and astroglia distributed around small blood vessels at the depths of cortical sulci and in an irregular pattern,” based on review of 25 tauopathy cases. In 2016, the consensus panel met again to review and refine the preliminary criteria, with consideration around the minimum threshold for diagnosis and the reproducibility of a proposed pathological staging scheme. Eight neuropathologists evaluated 27 cases of tauopathies (17 CTE cases), blinded to clinical and demographic information. Generalized estimating equation analyses showed a statistically significant association between the raters and CTE diagnosis for both the blinded (OR = 72.11, 95% CI = 19.5–267.0) and unblinded rounds (OR = 256.91, 95% CI = 63.6–1558.6). Based on the challenges in assigning CTE stage, the panel proposed a working protocol including a minimum threshold for CTE diagnosis and an algorithm for the assessment of CTE severity as “Low CTE” or “High CTE” for use in future clinical, pathological, and molecular studies.
How to Capture Reciprocal Communication Dynamics: Comparing Longitudinal Statistical Approaches in Order to Analyze Within- and Between-Person Effects
Authors: Thomas Fabian , Shehata Adam , Otto Lukas P , Möller Judith , Prestele Elisabeth 
Published: February 2021

Abstract
Choosing an appropriate statistical model to analyze reciprocal relations between individuals’ attitudes, beliefs, or behaviors over time can be challenging. Often, decisions for or against specific models are rather implicit and it remains unclear whether the statistical approach fits the theory of interest. For longitudinal models, this is problematic since within- and between-person processes can be confounded leading to wrong conclusions. Taking the perspective of the reinforcing spirals model (RSM) focusing on media effects and selection, we compare six statistical models that were recently used to analyze the RSM and show their ability to separate within- and between-person components. Using empirical data capturing respondents’ development during adolescence, we show that results vary across statistical models. Further, Monte Carlo simulations indicate that some approaches might lead to wrong conclusions if specific communication dynamics are present. In sum, we recommend using approaches that explicitly model and clearly separate within- and between-person effects.
Modulation of multiple cellular signalling pathways as targets for anti-inflammatory and anti-tumorigenesis action of Scopoletin
Authors: Sakthivel Kunnathur Murugesan , Vishnupriya Selvaraj , Priya Dharshini Loganathan Chandramani , Rasmi Rajan Radha , Ramesh Balasubramanian 
Published: February 2021

Abstract

Objectives
Scopoletin (6-methoxy-7-hydroxycoumarin) is a naturally occurring coumarin belonging to the category of secondary metabolites. Coumarins are commonly found in several herbs and play a prominent role in the defense mechanism of plants. Beneficial effects of scopoletin including antioxidant, anti-diabetic, hepatoprotective, neuroprotective and anti-microbial activity induced via numerous intracellular signalling mechanisms have been widely studied. However, anti-inflammation and anti-tumorigenesis properties of scopoletin are not well documented in the literature. Therefore, the primary focus of the present review was to highlight the plethora of research pertaining to the signalling mechanisms associated with the prevention of the progression of disease condition by scopoletin.

Key findings
Multiple signalling pathways like nuclear erythroid factor-2 (NEF2)-related factor-2 (NRF-2), apoptosis/p53 signalling, nuclear factor-κB (NF-κB) signalling, autophagy signalling, hypoxia signalling, signal transducer and activator of transcription-3 (STAT3) signalling, Wnt-β signalling, Notch signalling are coupled with the anti-inflammation and anti-tumorigenesis potential of scopoletin.

Summary
Understanding crucial targets in these molecular signalling pathways may support the role of scopoletin as a promising naturally derived bioactive compound for the treatment of several diseases.