bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mismatch Repair Deficiency, Chemotherapy and Survival for Resectable Gastric Cancer: an Observational Study from the German staR Cohort and a Meta-Analysis
Authors: Stolze Thilo , Franke Sabine , Haybaeck Johannes , Moehler Markus , Grimminger Peter P. , Lang Hauke , Roth Wilfried , Gockel Ines , Kreuser Nicole , Bläker Hendrik , Wittekind Christian , Lordick Florian , Vieth Michael , Veits Lothar , Waidmann Oliver , Lingohr Philipp , Peitz Ulrich , Schildberg Claus , Kruschewski Martin , Vassos Nikolaos , Goni Elisabetta , Bruns Christiane J. , Ridwelski Karsten , Wolff Stefanie , Lippert Hans , Schumacher Johannes , Malfertheiner Peter , Venerito Marino 
Published: December 2021

Abstract
Purpose. In a post hoc analysis of the MAGIC trial, patients with curatively resected gastric cancer (GC) and mismatch repair (MMR) deficiency (MMRd) had better median overall survival (OS) when treated with surgery alone but worse median OS when treated with additional chemotherapy. Further data are required to corroborate these findings.Methods. Between April 2013 and December 2018, 458 patients with curatively resected GC, including cancers of the esophagogastric junction Siewert type II and III, were identified in the German centers of the staR consortium. Tumor sections were assessed for expression of MLH1, MSH2, MSH6 and PMS2 by immunohistochemistry. The association between MMR status and survival was assessed. Similar studies published up to January 2021 were then identified in a MEDLINE search for a meta-analysis. Results. MMR-status and survival data were available for 223 patients (median age 66 years, 62.8% male), 23 patients were MMRd (10.3%). After matching for baseline clinical characteristics, median OS was not reached in any subgroup. Compared to perioperative chemotherapy, patients receiving surgery alone with MMRd and MMRp had a HR of 0.67 (95% CI: 0.13-3.37, P=0.63) and 1.44 (95% CI: 0.66-3.13, P=0.36), respectively. The meta-analysis included pooled data from 385 patients. Compared to perioperative chemotherapy, patients receiving surgery alone with MMRd had an improved OS with a HR of 0.36 (95% CI: 0.14-0.91, P=0.03), whereas those with MMRp had a HR of 1.18 (95% CI: 0.89-1.58, P=0.26).Conclusion. Our data support a positive prognostic effect for MMRd in GC patients treated with surgery only and a differentially negative prognostic effect in patients treated with perioperative chemotherapy. MMR status determined by preoperative biopsies may be used as a predictive biomarker to select patients for perioperative chemotherapy in curatively resectable GC.
Structural, Optical, Magnetic and Photon Attenuation of Novel Potassium Lead Borate Glasses Doped with MnO
Authors: Abouhaswa A. S. , Rammah Y. S. 
Published: December 2021

Abstract
Potassium lead borate glasses doped with MnO (40B2O3+40PbO+(20-x)K2O+xMnO: x= 0-5 mol%) have been prepared via standard melting quenching process. The impact of MnO on the structure, optical, magnetic and gamma-ray protection properties of pottisium lead borate glasses have been examined. The density was increased from 4.83±0.01 to 5.23±0.01 g/cm3 as MnO content increased. The obtained direct optical gap (Eg) values were 2.84, 2.59, 2.41, 2.19, 1.95, and 1.84 eV for the Mn-x (x=0, 1, 2, 3, 4, and 5) glass samples, respectively. FTIR spectra demonstrated that as the MnO concentration increases in the glass network the intensity and width of the IR bands were increased. The magnetic measurement revealed that the magnetic situation (Ms) was decreased while the magnetic coercivity (Hc) was increased with increasing MnO substitution ratio. The linear attenuation coefficient of the follows the order: µMn-0 < µMn-1 < µMn-2 < µMn-3 < µMn-4 < µMn-5. Half value layer (HVL) rises as µ decreases and vice versa. The range of the HVL is 0.002 – 3.378, 0.002 – 3.334, 0.002 – 3.291, 0.002 – 3.248, 0.002 – 3.176, and 0.002 – 3.106 cm for Mn-x (x=0, 1, 2, 3, 4, and5). The trend of Zeff variation is related to that of both linear and mass attenuation coefficients (µ and µm). The produced Mn-glasses can be employed in a variety of optical, magnetic and radiation protective applications.
Intranasal inhibitor blocks omicron and other variants of SARS-CoV-2
Authors: Mäkelä Anna R. , Uğurlu Hasan , Hannula Liina , Salminen Petja , Kant Ravi , Fagerlund Riku , Haveri Anu , Strandin Tomas , Kareinen Lauri , Hepojoki Jussi , Levanov Lev , Pasternack Arja , Naves Rauno A. , Ritvos Olli , Österlund Pamela , Sironen Tarja , Vapalahti Olli , Kipar Anja , Huiskonen Juha T. , Rissanen Ilona , Saksela Kalle 
Published: December 2021

Abstract
The emergence of the SARS-CoV-2 Omicron variant capable of escaping neutralizing antibodies emphasizes the need for prophylactic strategies to complement vaccination in fighting the COVID-19 pandemic. Nasal epithelium is rich in the ACE2 receptor and important for SARS-CoV-2 transmission by supporting early viral replication before seeding to the lung1. Intranasal administration of SARS-CoV-2 neutralizing antibodies or antibody fragments has shown encouraging potential as a protective measure in animal models2-5. However, there remains a need for SARS-CoV-2 blocking agents that are more economical to produce in large scale, while less vulnerable to mutational variation in the neutralization epitopes of the viral Spike glycoprotein. Here we describe TriSb92, a highly manufacturable trimeric human nephrocystin SH3 domain-derived antibody mimetic targeted against a conserved region in the receptor-binding domain of the Spike. TriSb92 potently neutralizes SARS-CoV-2 and its variants of concern, including Delta and Omicron. Intranasal administration of a modest dose of TriSb92 (5 or 50 micrograms) as early as eight hours before the challenge with SARS-CoV-2 B.1.351 efficiently protected mice from infection. The target epitope of TriSb92 was defined by cryo-EM, which revealed triggering of a conformational shift in the Spike trimer rather than competition for ACE2 binding as the molecular basis of its strong inhibitory action. Our results highlight the potential of intranasal inhibitors in protecting susceptible individuals from SARS-CoV-2 infection, and describe a novel type of inhibitor that could be of use in addressing the challenge posed by the Omicron variant.
The Component of the TAC Complex, TCD7, Controls Rice Chloroplast Development at the Early Seedling Stage under Cold Stress
Authors: Lin Dongzhi , Kang Licheng , Zhou Wenhao , Wang Yulu , Chen Yu , Xu Jianlong , Dong Yanjun 
Published: December 2021

Abstract
Transcriptionally active chromosome (TAC) is a component of protein-DNA complexes with RNA polymerase activity found in chloroplasts. Although TAC in Arabidopsis thaliana has been extensively investigated, how the rice (Oryza sativa L.) TAC complex functions remains largely unknown. We report the characterization of the mutant thermosensitive chlorophyll-deficient7 (tcd7) and the cloning of TCD7. tcd7 mutant seedlings displayed an albino phenotype specifically at low temperatures and before the four-leaf stage. We identified TCD7 by map-based cloning followed by transgenic rescue and genome editing tests, showing that TCD7 encodes the putative TAC component FRUCTOKINASE-LIKE 2 (OsFLN2). TCD7 transcripts were highly abundant in green tissues, and the protein localized to chloroplasts. In agreement with the albino phenotype, transcript levels of genes controlling chloroplast development and the establishment of photosynthetic capacity were severely reduced in tcd7 seedlings at low temperatures, but were expressed as in the wild type at high temperatures, implying that TCD7 regulates the PEP pathway and chloroplast development. Moreover, TCD7 interacted with the thioredoxin OsTRXz to form an OsTRXz-TCD7 regulatory module, which might regulate plastid transcription under cold stress. Our results demonstrate that the nucleus-encoded TAC protein TCD7 protects chloroplast development from cold stress via a TRXz-FLN regulatory module.
Customer satisfaction with Tokyo Metropolitan Government ward office counter services: confirmatory factor analysis of question grouping and principal component regression analysis
Authors: Moteki Yasutoshi 
Published: December 2021

Abstract
This study examines the determinants of service satisfaction among users of a ward office in Tokyo using a two-part questionnaire. The questionnaire comprised three main categories of multiple-choice questions: A) facility equipment (physical elements in the government office), B) staff responses, and C) service delivery (e.g., promptness of services, whether visitors completed their scheduled errands). In addition, three groups of questions related to the personalities of the users of each facility were investigated. During a one-day survey period, responses were collected from 400 women, aged 30–59 years, who had visited a ward office in the Tokyo Metropolitan Area over a one-month period. This age segment was studied because it is the major segment of the panel of the Internet research firm used. First, factor analysis was used to check the appropriateness of the grouping of questions, and it was confirmed that the three groups were appropriate based on eigenvalues and scree plots. Then, to examine the determinants of counter service customer satisfaction, principal component analysis and multiple regression analysis were conducted for each question category. The regression analysis using the three main question groups and three other respondents’ personality-related question groups indicated that group C (service delivery quality) had the strongest influence on the dependent variable, followed by group B and group A. The adjusted R2 value was .70. This result is consistent with the results of the author’s surveys of government offices in urban areas conducted for Higashihiroshima City Hall and of ward offices in Osaka.
The spatially homogeneous Hopf bifurcation induced jointly by memory and general delays in a diffusive system
Authors: Lv Yehu 
Published: December 2021

Abstract
In this paper, by incorporating the general delay to the reaction term in the memory-based diffusive system, we propose a diffusive system with memory delay and general delay (e.g., gestation, hunting, migration and maturation delays, etc.). We first derive an algorithm for calculating the normal form of Hopf bifurcation in a diffusive system with memory and general delays. The developed algorithm for calculating the normal form can be used to investigate the direction and stability of Hopf bifurcation. Then, we consider a diffusive predator-prey model with ratio-dependent Holling type-3 functional response, which includes with memory and gestation delays. The Hopf bifurcation analysis without considering gestation delay is first studied, then the Hopf bifurcation analysis with memory and gestation delays is studied. Furthermore, by using the developed algorithm for calculating the normal form, the supercritical and stable spatially homogeneous periodic solutions induced jointly by memory and general delays are found theoretically. The stable spatially homogeneous periodic solutions are also found by the numerical simulations which confirms our analytic result.
Epidemiologic Factors and Ocular Manifestations of Twin Children Compared with Controls
Authors: Rajavi Zhale , Sabbaghi Hamideh , Hasani Reza , Behradfar Narges , Abdi Saeid , Kheiri Bahareh 
Published: December 2021

Abstract
Purpose: To compare the epidemiological and ocular findings of twin children with non- twin age matched individuals as their control.Methods: In this cross sectional study, a total of 92 twins (184 cases) were compared with 182 non- twin matched children. The comprehensive ophthalmic examinations including measurement of the best corrected visual acuity (BCVA), cycloplegic refraction, ocular deviation, strabismus as well as the anterior and posterior ophthalmic examinations were conducted. An organized questionnaire was also filled out for both groups to record their demographic information. Monozygotic twins were considered if there were similarity of their phenotypic characteristics and gender, otherwise the twins were considered as dizygotic. The mirror- image twins (MIT) was defined based on the laterality of symmetrical ocular characteristics of twins.Results: In this study, the mean age of the study subjects was 7.08±4.68 and 7.56±4.02 years in the twins and non-twins groups, respectively. Among the twins 27 (30%) were monozygotic. Refractive form of MIT was seen in 5 twins (5%). BCVA in the twins group (0.07±0.16LogMAR) was significantly worse than non-twins (0.03±0.08LogMAR, P<0.001) and higher percentage of them were amblyopic (21.8% versus 10.5%, P=0.005). Twin and controls had history of strabismus surgery in 7.8% and 3.3%, respectively (P=0.009). Multivariate analysis showed significant correlation among low gestational age and female gender, low birth weight and seizure. Conclusion: Female sex, less gestational age, low birth weight, amblyopia and strabismus were significantly higher in twins. Therefore, it is important to check their refractive error, anisometropia, MIT phenomenon and amblyopia to prevent their further complications.
Extraction and Characterization of Chitin, Chitosan, and Protein Hydrolysate From the Invasive Pacific Blue Crab, Portunus Segnis (Forskål, 1775) Having Potential Biological Activities
Authors: Jabeur Fadoua , Mechri Sondes , Mensi Fethi , Gharbi Ines , Naser Yosri Ben , Kriaa Mouna , Bejaoui Nejla , Bachouche Samir , Badis Abdelmalek , Annane Rachid , Djellali Mostapha , Sadok Saloua , Jaouadi Bassem 
Published: December 2021

Abstract
The diversity of marine biomasses is a set of exploitable and renewable resources with application in several sectors. In this context, a co-culture based on three protease-producing bacterial isolates namely; Aeribacillus pallidus VP3, Lysinibacillus fusiformis C250R, and Anoxybacillus kamchatkensis M1V strains, was carried out in a medium based on the blue swimming crab Portunus segnis bio-waste. Proteases production was optimized using a central composite design (CCD). The highest level of proteases production obtained was 8,809 U/mL in a medium comprising 75 g/L of Portunus segnis by-product powder (Pspp). The biological value of Pspp and its obtained derivates were evidenced via accredited protocols. The recovered protein hydrolysate (PHyd) was found to be active towards radical scavenging power, and against angiotensin I-converting enzyme (ACE). The blue crab chitin (BC) extraction efficiency was achieved with a yield of 32%. Afterward, chitosan was prepared through chitin N-deacetylation with a yield of 52%, leading to an acetylation degree (AD) of 19% and solubility of 90%. In addition, chitosan is found to be active against the growth of all pathogenic bacteria tested.
The determinants of Islamic social reporting disclosure and its impact on the profitability of sharia banks
Authors: Mubarok Sultan Mubarok 
Published: December 2021

Purpose - This study aims to determine of disclosure level of Islamic Social Reporting (ISR) and its impact on profitability at Sharia Commercial Bank in Indonesia.Method - This study uses Good Corporate Governance (GCG), which is proxied with self-assessment, number of commissioners, and number of Sharia Supervisory Board (DPS), financial is proxied with company size, company age, DER, Social Cost, BOPO, FDR, and NPF. Profitability is proxied with ROA and ROE. The sampling technique used a purposive sampling method. There are 12 Sharia Banks that meet the criteria of the study sample period 2013-2017.The result - The results showed that: first, GCG hurt ISR. Second, financial factors have a positive effect on ISR. Third, GCG negative affects profitability; the greater the number of commissioners and DPS will have an impact on the material costs of the Bank. Fourth, financial factors have a positive effect on profitability. Fifth, ISR hurts profitability. Sixth, ISR mediates the relationship between GCG and financial factors with profitability.Implication - This study helps sharia banks to maintain Islamic Social Reporting as a tool to get stakeholders’ trustOriginality - This study uses a corporate social responsibility report, which also presents the aspect of religiosity.
Factors affecting public housing credit choice of sharia property developer in Central Java
Authors: Lailyah Nurzahroh 
Published: December 2021

Purpose – This study analyses the various factors that affect the probability of consumers choosing public housing credit (PHC) of Sharia Property Developer (SPD) in Central Java.Method – The data of this study are primary data obtained through questionnaires to 252 people from a population of 1,269 PHC SPD consumers in Central Java (Boyolali Regency, Magelang Regency, Pati Regency, Semarang City, and Wonosobo Regency). Furthermore, consumer data were analysed using a binary logit regression model with SPSS software.Result – The results of this study state that the variable price and religiosity have a significant negative effect on the probability of choosing a PHC in Islamic Property Developer. In comparison, the variables of income, location, and facilities do not significantly affect the likelihood of selecting a PHC on a Sharia Property Developer. Wonosobo Regency is the region with the most significant probability of choosing a PHC on a Sharia Property Developer compared to Boyolali, Pati, Magelang, and Semarang City Regencies. Meanwhile, Pati Regency is the region with the least probability of choosing a PHC as a Sharia Property Developer. Implication – The Central Java SPD can use the finding of this research to consider the evaluation and improvement of PHC products in the future. So that consumers do not turn to competitors, have more confidence, and are satisfied with Sharia Property Developer services.Originality – The originality of this research lies in the object under study, test analysis, and research location.
SEREBRAL PALSİLİ ÇOCUKLARDA ORAL MOTOR VE YUTMA BOZUKLUKLARI İLE İLİŞKİLİ ÖZELLİKLERİN İNCELENMESİ: TANIMLAYICI BİR ÇALIŞMA
Authors: İNAL Özgü , SEREL ARSLAN Selen , DEMIR Numan , KARADUMAN Aynur Ayşe 
Published: December 2021

Amaç: Serebral Palsili (SP) çocuklarda oral motor problemler ve yutma bozukluğu yaygın olarak görülmektedir. Bu çalışma, SP’li çocukların oral motor ve yutma bozukluğu ile ilgili tanımlayıcı özelliklerini incelemek amacı ile planlandı.
Yöntem: Bu çalışma, yaş ortalaması 70.35±28.30 ay olan 90 SP’li çocuk (39 kız, 51 erkek) ile gerçekleştirildi. Motor fonksiyonel seviye için Kaba Motor Fonksiyon Sınıflandırma Sistemi (KMFSS) kullanıldı. Dil itme şiddetinin değerlendirilmesi için Dil İtme Derecelendirme Ölçeği (TTRS), salya problemi için Salya Şiddet ve Frekans Ölçeği, çiğneme performans seviyesi için Karaduman Çiğneme Performans Ölçeği (KCPS) ve yutma bozukluğu için Pediatrik Yeme Değerlendirme Aracı (PEDI-EAT-10) kullanıldı.
Sonuçlar: KMFSS’ye göre çocukların % 55,6'sı seviye V düzeyindeydi. Çocukların %87,8'inde patolojik dil itme refleksi vardı. Ortalama PEDI-EAT-10 skoru 15,42±11,41 idi. SP’li çocukların %87,8'inde çiğneme bozukluğu ve % 87,8'inde salya problemi saptandı. GMFCS düzeyi, klinik SP tipi, open mouth varlığı, besin kıvamı ve pnömoni sayısı tüm oral motor ve yutma değerlendirmeleri ile korelasyon gösterdi (p
TÜRKİYE’DE FİZYOTERAPİ VE REHABİLİTASYON ALANINDA YAPILAN DOKTORA TEZLERİNİN TEMATİK ve METODOLOJİK AÇIDAN İNCELENMESİ ARAŞTIRMA MAKALESİ
Authors: ÇINAR Murat Ali , TURHAN Begümhan , BADAT Tuğba , BAYRAMLAR Kezban , YAKUT Yavuz 
Published: December 2021

Amaç: Doktora eğitimi, her mesleğin gelişiminde olduğu gibi fizyoterapi mesleğinin gelişimi için de oldukça önemlidir. Bu araştırma Türkiye’de fizyoterapi alanında yapılan doktora tezlerinin tematik ve metodolojik açıdan özelliklerini değerlendirmek amacıyla yapılmıştır.
Yöntem: Bu çalışma kapsamında Türkiye Cumhuriyeti Yüksek Öğretim Kurulu’nun “Ulusal Tez Merkezi” resmi web sitesinde yer alan Fizyoterapi ve Rehabilitasyon alanında yapılan tezler tarandı. 1971 yılı ile 15 Ekim 2020 tarihleri arasında fizyoterapi ve rehabilitasyon alanında yapılan ve Yükseköğretim Kurumu elektronik tez arşivinde kayıtlı olan 422 doktora tezi incelenmiştir. Tezleri incelemede araştırmacılar tarafından geliştirilen tez inceleme formu kullanılmıştır.
Sonuçlar: Türkiye’de fizyoterapi ve rehabilitasyon alanında doktora eğitimi verilen üniversite sayısı 19’dur. Doktora eğitimi veren 4 vakıf üniversitesi bulunmaktadır. İncelenen doktora tezlerinde, tez danışmanlarının %81 (n=341) profesör unvanına sahip olduğu belirlendi. Yapılan tezlerin örneklem sayı aralığının 8-1563 arasında değiştiği gözlendi. Alanlar açısından tezlere bakıldığında, en fazla tezin nöroloji alanında yapıldığı görüldü. Tüm araştırmacıların 329’unun kadın (%78), 93’ünün (%22) de erkek olduğu belirlendi.
Tartışma: Doktora eğitimi alan ya da alacak olan fizyoterapi öğrencilerinin tez konusu seçiminde Yükseköğretim Kurulunun belirlemiş olduğu öncelikli alanlar ile ulusal ve uluslararası kabul gören alanları dikkate almalarının önemli olduğu görüşündeyiz. Sonuç olarak bu çalışmanın ileride yapılacak olan doktora tezlerinin niteliğini arttırmaya katkı sağlayacağı düşünülmektedir.
Comparative Genomics and Evolution of Avian Specialized Traits
Authors: Wu Lei , Jiao Xiaolu , Zhang Dezhi , Cheng Yalin , Song Gang , Qu Yanhua , Lei Fumin 
Published: December 2021

Abstract:
Genomic data are important for understanding the origin and evolution of traits. Under the context of rapidly developing sequencing technologies and more widely available genome sequences, researchers are able to study evolutionary mechanisms of traits via comparative genomic methods. Compared with other vertebrates, bird genomes are relatively small and exhibit conserved synteny with few repetitive elements, which makes them suitable for evolutionary studies. Increasing genomic progress has been reported on the evolution of powered flight, body size variation, beak morphology, plumage coloration, high-elevation colonization, migration, and vocalization. By summarizing previous studies, we demonstrate the genetic bases of trait evolution, highlighting the roles of small-scale sequence variation, genomic structural variation, and changes in gene interaction networks. We suggest that future studies should focus on improving the quality of reference genomes, exploring the evolution of regulatory elements and networks, and combining genomic data with morphological, ecological, behavioral, and developmental biology data.