bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of intra-operative tracheal injuries during transhiatal esophagectomy
Authors: Ganie Farooq Ahmad , Lone Ghulam Nabi , Manzoor Syed Mohsin , Ashraf Hakeem Zubair , Kawoosa Nadeem ul Nazir , Gul Rouf 
Published: June 2021

Background and objective: In transhiatal esophagectomy, iatrogenic injuries to trachea are very uncommon but when it happens it is potentially lethal and has high morbidity. This study aimed to investigate the incidence and outcome of tracheal injuries during transhiatal esophagectomy.
Methods: The medical records of 608 patients who underwent transhiatal esophagectomy for esophageal cancer from January 2000 to January 2019 were analyzed.
Results: Out of 608 transhiatal esophagectomy, four (0.66%) patients sustained injuries to major airway. Three injuries occurred during transhiatal and one injury during transcervical part of dissection. All the injuries occurred in trachea proximal to carina. All four injuries were closed primarily, re-enforced by muscle and fascial pledgets.
Conclusion: Tracheobronchial injury is a rare complication of transhiatal esophagectomy, mostly seen in patients who receive neo-adjuvant therapy or have locally advanced growth with dense adhesions. Its immediate recognition and closure decreases the mortality and morbidity associated with this rare but fatal intra-operative complication. It can be managed effectively by primary closure, with or without muscle and fascial pledget reinforcement.
Ibrahim Med. Coll. J. 2021; 15(1): 26-30
Cambio de uso de suelo en la Amazonía norte del Ecuador:un análisis a través de imágenes satelitales nocturnas VIIRS e imágenes LANDSAT
Authors: Mejia Veronica , Orellana Diana , Cabrera Pablo 
Published: June 2021

Se ha visto que estos últimos años las presiones sobre el territorio y los pueblos amazónicos se han vuelto cada vez más visibles debido a las transformaciones del suelo y las dinámicas territoriales sobre estas zonas antes consideradas remotas y en las que habitan pueblos primigenios. Frente a este contexto, se ha querido cuantificar los cambios en el territorio por actividades antrópicas cuantificando las transformaciones del suelo y los impactos sobre suelo no artificializado. En este sentido, se emplean imágenes satelitales nocturnas y diurnas que nos permiten cuantificar la evolución de los niveles de radiancia y los cambios en los NDVI. Estos dos indicadores nos permiten visualizar de manera clara las trasformaciones en los usos del suelo y los impactos de radiancia sobre el territorio. En este sentido, se ha corroborado que los impactos vinculados con la expansión de la frontera agrícola y urbana incrementan anualmente sus superficies a tasas que superan los 4,5% y que las actividades antrópicas se vinculan con las temperaturas más elevadas del territorio propiciando un cambio de las características propias de los ecosistemas selváticos. Estos resultados evidencian la perdida de bosques tropicales, pero también y los impactos sobre los pueblos primigenios que habitan estos territorios.
Palabras clave: Landsat, VIIRS, cambio de suelo, NDVI, Amazonía.
AbstractIn the last years the pressures on the Amazon have increasingly become visible due to the transformations of the land and alteration of territorial dynamics in areas previously considered remote and only inhabited by indigenous nations. In this context, we evaluate anthropic-based changes by quantifying the transformations of land use and the impacts on non-artifcialized areas. Using night and day satellite images, we quantify the evolution of radiance levels and changes in NDVI since 2012. We obtained a visualization of the transformations in land use and the radiance impacts on the territory. In this sense, this study found that the impacts related tothe expansion of the agricultural and urban frontier increase their infuence areas at rates that exceed 4.5%/year and that anthropic activities are linked to the highest temperatures in the territory, motivating a change of the characteristics of rainforest ecosystems. These results show the loss of tropical forests, but also suggests impacts on the indigenous inhabitants of these territories.
Keywords: Landsat, VIIRS, soil change, NDVI, Amazon.
Efek Komposisi Biochar dan Pasir pada Media Tanam Hidroganik serta Dosis Vermikompos Terhadap Pertumbuhan dan Hasil Tanaman Selada Keriting (Lactuca sativa L.)
Authors: Hartina Siti , Nurhidayati Nurhidayati , Murwani Indiyah 
Published: June 2021

This study aims to determine the interaction of the composition of planting media and vermicompost dosage on the growth and yield of lettuce plants. This study is a pot experiment conducted by green house located on Jl. MT. Haryono, Dinoyo Subdistrict, Lowokwaru Subdistrict, Malang with a altitude of ± 550 meters above sea level, the average air temperature ranges from 20 °C - 28 °C, which starts in February to June 2019. The study uses experimental Randomized Block Design (RBD) arranged in factorial and consists of 2 factors. The first factor was the composition of the planting medium consisting of 2 levels, namely M1: Cocopit (55%), Biochar (15%), Sand (30%) and M2: Cocopit (55%), Biochar (30%), Sand (15%) The second factor is the vermicompost dose which consists of five types, namely V1: 50 gram / pot, V2: 100 gram / pot, V3: 150 gram / pot, V4: 200 gram / pot, and V5: 250 gram / pot. Based on the two factors, 10 treatments were obtained and each treatment was repeated 3 times with 5 plant samples per treatment, until a sample of 150 lettuce plants was obtained. The results showed that the composition of the planting medium gave growth and yield of different lettuce plants, where the composition of M1 planting media (cocopeat 55%, 15% biochar and 30% sand) gave the highest growth and yield of plants at the dosage application of 200-250 g / pot while the composition of M2 planting media (55% cocopeat, 30% biochar and 15% sand), gave the highest growth and yield at 150-250 g / pot vermicompost doses. This is caused by the influence of the composition of the planting medium and vermicompost dosage on the total fresh weight of plants, fresh weight of roots and fresh weight economically valuable curly lettuce M2V4 treatment (55% cocopeat growing media, 30% biochar and 15% sand, with vermicompost 200 gram / pot), M2V1 (planting media, 55% cocopeat, 15% biochar and 30% sand, with 50 gram vermicompost / pot dose) and M2V4 (planting media, 55% cocopeat, 30% biochar and 15% sand, with dosage 200 gram vermicompost / pot) with values of 66.06, 6.24 and 61.62 grams giving the highest results. Keywords: planting media composition, vermicompost dosage
Respon Dua Varietas Tanaman Kentang (Solanum tuerosum L.) Terhadap Aplikasi Pupuk Majemuk NPK
Authors: Quraisyin Dian Nitami , Sugiarto Sugiarto , Nurhidayati Nurhidayati 
Published: June 2021

Demand for potatoes from time to time is increasing. Therefore it is necessary to increase the productivity of potatoes through appropriate cultivation techniques especially in new potato varieties. This study aims to determine the effect of NPK (16:16:16) fertilizer dosage on the growth and yield of two potato varieties in the highlands.The design used was factorial Randomized Block Design (RAK) using 2 factors. The first factor was the aplication of NPK fertilizer with 3 levels, namely P0 = without fertilizer, P1 = 400 kg fertilizer NPK ha-1 and P2 = 800 kg NPK fertilizer ha-1. The second factor is the type of variety with 2 levels, V1 = Granola L and V2 = Granolla Arjuno. Of these two factors, there were six treatment, Each treatment was repeated 3 times. There are two observed variables which are growth variables (plant height, number of stems, number of leaves and stem diameter) and yield variables (number of tubers, weight of , tuber per plot and per hectare). The data collected was analyzed based on F Test at the level of 5% and LSD test 5%. The results showed that the best plant growth was Granolla Arjuno variety with a dose of NPK fertilizer 400 kg ha-1 (P1V2). While the treatment that gives the highest results is Granolla Arjuno variety with a dose of N-P-K fertilizer 400 kg ha-1 (P1V2)
PENGARUH PEMBERIAN PROBIOTIK Bacillus subtillis DAN Saccharomyces cerevisiae TERHADAP PRODUKSI AYAM LAYER UMUR 48 MINGGU
Authors: Hanani Rizal Nurhanani , Lisnanti E. F. , Rudiono D. 
Published: June 2021

2000 ekor lapisan Isa Brown digunakan untuk mengetahui pengaruh bakteri Bacillus subtilis dan Saccharhomyces cerevisiae yang menggunakan 'siap dicampur dalam bentuk pakan probiotik' terhadap kinerja bertelur pada umur 48 minggu. Evaluasi dilakukan selama 4 minggu masa peletakan yang berlokasi di Desa Mbakung , Kecamatan Kademangan S ub, Kota Blitar. Perlakuan pakan dibagi menjadi dua kelompok yaitu: P0 (dedak padi 15% + jagung 45% + konsentrat 35% + mineral 3% + toksin 2% + premiks 5%) dan P1 ( dedak padi 15% + jagung 45%). + 35% konsentrat + probiotik); Maka untuk analisisnya menggunakan uji t. Perlakuan diulang sebanyak 20 kali dan masing-masing terdiri dari 50 ekor ayam. Parameter tersebut meliputi: Konsumsi Pakan (g / ekor / hari); Produksi Hari Induk (%); Produksi Rumah Induk (%); Berat Telur (g / ekor / hari); Massa Telur (g); Rasio Konversi Pakan; dan Income Over Feed Cost (Rp / hari). Hasil penelitian menunjukkan terdapat pengaruh yang signifikan (P <0,05) terhadap parameter: Produksi Hen Day (85,29% vs 81,27%); Produksi Rumah Induk (84,49% vs 80,09%); Konsumsi Pakan (117,65 g / ekor / hari vs 118,47 g / ekor / hari); Rasio Konversi Pakan (2,16 vs 2,29); Massa Telur (54,78g vs 52,30g); Pendapatan Over Feed Cost (Rp 233,10 / hari vs Rp 185,25 / hari). Namun tidak terdapat pengaruh yang signifikan (P> 0,05) terhadap Bobot Telur (64,26g vs 64,40g). Kesimpulannya adalah penggunaan Bacillus subtilis dan Saccharomyces Cerevisae dapat meningkatkan kinerja petelur pada minggu ke 48. Disarankan perlu dilakukan penelitian lebih lanjut agar dapat digunakan dalam peningkatan produksi ayam petelur.
PENGARUH PEMBERIAN PROBIOTIK Bacillus subtilis DAN Saccharomyces cerevisiae TERHADAP PRODUKSI AYAM LAYER UMUR 51 MINGGU
Authors: Alfani Rizal , Lisnanti E. F. , Rudiono D. 
Published: June 2021

2000 ekor ayam isa brown untuk menentukan efek dari bakteri Bacillus subtilis dan Saccharomyces cerevisiae yang digunakan dalam bentuk probiotik tercampur dalam pakan untuk menghasilkan produksi pada umur 51 minggu. Evaluasi dilakukan selama 8 minggu masa peletakan di Desa mronjo, kecamatan Selopuro, Kabupaten blitar. Perlakuan dibagi menjadi dua kelompok, yaitu; P0 (jagung 50% + konsentrat 35% + bekatul 15% + premix 0,2%) dan P1 (Jagung 50% + konsentrat 35% + bekatul 15% + probiotik 0,1%) dianalisis menggunakan t test. Perlakuan diulang 20 kali dengan masing masing terdapat 50 ekor ayam. Parameter meliputi: Konsumsi Pakan (g/ekor), Feed Convertion Ratio, Berat telur (g/butir), Hen Day Production (%), Hen House Production (%), Egg Mass (g/ekor), Income Over Feed Cost (Rp/day). Hasil penelitian menunjukan bahwa berbeda nyata (P>0,05) pada Konsumsi Pakan (114,35 vs 113,78 g/ekor/hari); Feed Convertion Ratio (2,43 vs 2,51); Hen Day Production (75,91 vs 73,72%); Hen House Production (74,96 vs 72,53%); Egg Mass (48,21 vs 46,74 g/ekor/hari); Income Over Feed Cost (157,26 vs 123,50 Rp/ekor) tetapi tidak berbeda nyata pada berat telur ( 63,50 vs 63,50 g/butir). Kesimpulan hasil penelitian pemberian bakteri Bacillus subtilis dan Saccharomyces cerevisiae pada hasil produksi masih belum bisa optimal. Disarankan perlunya penelitian lebih lanjut agar dapat digunakan dalam meningkatkan produksi ayam petelur.
EVALUASI SINERESIS DAN SENSORI YOGURT DENGAN PENAMBAHAN STABILIZER PATI TALAS LOKAL (Colocasia esculenta) PADA MASA INKUBASI 18 JAM SUHU RUANG
Authors: Krisnaningsih Aju Tjatur Nugroho , Kustyorini Tri Ida Wahyu , Selviana Revi 
Published: June 2021

Tujuan dari penelitian untuk mengetahui pengaruh penambahan stabilizer pati talas lokal (Colocasia esculenta) terhadap sineresis dan sensori yogurt pada masa inkubasi 18 jam suhu ruang.Materi yang digunakan dalam penelitian ini adalah susu sapi segar, pati talas, susu skim, dan starter (Lactobacillus bulgaricus,Streptococcus thermophillus dan Lactobacillus acidhopilus). Metode penelitian yang digunakan adalah percobaan Laboratorium dengan menggunakan Rancangan Acak Lengkap (RAL). Perlakuan penelitian yakni penambahan pati talas, yaitu: P0 (0%), P1 (0,50%), P2 (1%), P3 (1,50%), P4 (2%) masing-masing perlakuan diulang sebanyak 4 kali. Data yang diperoleh dianalisis dengan analisis ragam, apabila terdapat perbedaan maka dilanjutkan dengan uji duncan. Variabel yang diamati meliputi: Sineresis dan Sensori yogurt. Hasil penelitian menunjukan bahwa penambahan level pati talas lokal (Colocasia esculenta) yang berbeda sebagai stabilizer memberikan pengaruh perbedaan yang sangat nyata (P<0,01) terhadap sineresis dan tekstur yogurt. Nilai Sineresis tertinggi dengan penambahan pati P0 (0%) sebesar 4,5% kemudian berturut-turut P1 (0,50%), P2 (1%), P3 (1,50%), P4 (2%) sebesar 4,23%, 4%, 3,72%, 3,48%. Pada kesukaan tekstur yogurt nilai tertinggi pada P3 dengan skor 3,8% dan nilai terendah yaitu P0 dengan skor nilai 3,13%. Penambahan pati tidak memberikan pengaruh (P>0,05) terhadap warna, rasa dan aroma yogurt. Berdasarkan hasil penelitian dapat disimpulkan bahwa penambahan pati talas 1,50% pada masa inkubasi 18 jam suhu ruang dapat menghasilkan yogurt yang optimal ditinjau dari sineresis dan sensori yogurt.
АМИШИ СТАРОГО ПОРЯДКА: КОНСЕРВАТИВНАЯ РЕЛИГИОЗНОСТЬ, ОСТАНОВИВШАЯ ВРЕМЯ
Authors: Казьмина Ольга Евгеньевна 
Published: June 2021

В статье исследуются механизм формирования и сохранения очень своеобразной конфессиональной группы – амишей старого порядка и влияние религиозного учения на их повседневные практики. По существу, весь жизненный уклад амишей старого порядка определяется Орднунгом – сводом правил, позволяющим сохранять самобытность и приверженность традициям. В Орднунге выделяется письменная часть (составленные религиозными лидерами документы, содержащие основные догматические положения, обусловившие особенности религиозной и повседневной жизни) и устная (неписанные правила, постепенно складывавшиеся и определяющие отдельные детали быта). Устная часть Орднунга может несколько различаться в разных общинах и меняться с течением времени. Однако к любым переменам амиши старого порядка подходят очень осторожно – изменения могут касаться лишь незначительных частностей. Вся жизнь этой группы предполагает жесткую регламентацию норм поведения внутри общины и отношений с внешним миром; определены не только допустимые технологии, но и конкретные предметы хозяйства, быта и личного пользования. Амиши старого порядка верят, что Орднунг наставляет их на праведный путь и оберегает от грехов внешнего мира. Следование своему религиозному учению и своим традициям обеспечило формирование и воспроизводство амишей старого порядка как особой группы, сильно отличающейся от своего окружения не только религиозной принадлежностью. The article studies the formation and conservation of a very specific religious group – Old Order Amish, and how their religious doctrine affected their everyday practices. In fact, the whole life style of Old Order Amish is determined by Ordnung – a scope of rules that allowed them to preserve their distinctiveness and devotion to traditions. Ordnung consists of its written part (documents written by religious leaders that contain dogmatic statements determining specifics of religious and daily life) and oral part (unwritten rules that gradually developed in each community and determined particular details of daily life, not recorded in the written documents). Unwritten rules of the Ordnung may lightly vary in different communities and change over time. Yet, Old Order Amish are very cautious about any changes, which can only affect minor details. All their life is strictly regulated by the rules of conduct inside and outside the community and permitted technologies, tools and personal use items. Old Order Amish believe that Ordnung sets them on the right path and helps them not to let sins of the outside world into their lives. Following both religious doctrine and traditions determined by the oral part of Ordnung ensured the formation and reproduction of Old Order Amish as a particular group that dramatically differs from its neighboring population.
Рецензия на: Зубова А.В., Моисеев В.Г., Кульков А.М., Ободовский А.В. Новые результаты изучения краниологических и одонтологических материалов верхнепалеолитической стоянки Костенки 15 // Camera praehistorica, 2020. 2 (5): 147–155*
Authors: Герасимова Маргарита Михаайловна 
Published: June 2021

Рецензия на: Зубова А.В., Моисеев В.Г., Кульков А.М., Ободовский А.В. Новые результаты изучения краниологических и одонтологических материалов верхнепалеолитической стоянки Костенки 15 // Camera praehistorica, 2020. 2 (5): 147–155*
Review: Zubova, Alisa V., Moiseyev, Vyacheslav G., Kulkov Aleksandr M. and Anatoliy V. Obodovskiy. Reassessment of the cranial and dental data from the Upper Paleolithic site of Kostenki 15. Camera praehistorica 2 (5): 147–155
Cardiomyocyte Proliferative Capacity Is Restricted in Mice With Lmna Mutation
Authors: Onoue Kenji , Wakimoto Hiroko , Jiang Jiangming , Parfenov Michael , DePalma Steven , Conner David , Gorham Joshua , McKean David , Seidman Jonathan G. , Seidman Christine E. , Saito Yoshihiko 
Published: June 2021

LMNA is one of the leading causative genes of genetically inherited dilated cardiomyopathy (DCM). Unlike most DCM-causative genes, which encode sarcomeric or sarcomere-related proteins, LMNA encodes nuclear envelope proteins, lamin A and C, and does not directly associate with contractile function. However, a mutation in this gene could lead to the development of DCM. The molecular mechanism of how LMNA mutation contributes to DCM development remains largely unclear and yet to be elucidated. The objective of this study was to clarify the mechanism of developing DCM caused by LMNA mutation.Methods and Results: We assessed cardiomyocyte phenotypes and characteristics focusing on cell cycle activity in mice with Lmna mutation. Both cell number and cell size were reduced, cardiomyocytes were immature, and cell cycle activity was retarded in Lmna mutant mice at both 5 weeks and 2 years of age. RNA-sequencing and pathway analysis revealed “proliferation of cells” had the most substantial impact on Lmna mutant mice. Cdkn1a, which encodes the cell cycle regulating protein p21, was strongly upregulated in Lmna mutants, and upregulation of p21 was confirmed by Western blot and immunostaining. DNA damage, which is known to upregulate Cdkn1a, was more abundantly detected in Lmna mutant mice. To assess the proliferative capacity of cardiomyocytes, the apex of the neonate mouse heart was resected, and recovery from the insult was observed. A restricted cardiomyocyte proliferating capacity after resecting the apex of the heart was observed in Lmna mutant mice.Conclusions: Our results strongly suggest that loss of lamin function contributes to impaired cell proliferation through cell cycle defects. The inadequate inborn or responsive cell proliferation capacity plays an essential role in developing DCM with LMNA mutation.
Tumor Mutation Burden Predicts Relapse in Papillary Thyroid Carcinoma With Changes in Genes and Immune Microenvironment
Authors: Guo Mengli , Chen Zhen , Li Yayi , Li Sijin , Shen Fei , Gan Xiaoxiong , Feng Jianhua , Cai Wensong , Liu Qingzhi , Xu Bo 
Published: June 2021

BackgroundThe risk factors of papillary thyroid carcinoma (PTC) recurrence are meaningful for patients and clinicians. Tumor mutation burden (TMB) has been a biomarker for the effectiveness of immune checkpoint inhibitor (ICI) and prognosis in cancer. However, the role of TMB and its latent significance with immune cell infiltration in PTC are still unclear. Herein, we aimed to explore the effect of TMB on PTC prognosis.Material and MethodsRNA-seq and DNA-seq datasets of PTC patients were downloaded from The Cancer Genome Atlas (TCGA) database. The Gene Ontology (GO) and gene set enrichment analysis (GSEA 4.0.1) were applied further to explore potential differences in PTC patients’ biological functions. The differentially expressed genes (DEGs) and immune microenvironment between the high and low TMB groups were determined.ResultsTMB had the highest AUC score than other clinical indicators in ROC analysis on recurrence-free survival, and a higher TMB score was related to a worse prognosis. Further, GSEA showed a higher level of oxidative phosphorylation (OXPHOS) in the high TMB group, and four genes correlated with recurrence-free survival rate were identified. The abundance of CD8+ T cells and M1 macrophages in the high TMB group was significantly lower than that in the low TMB group.ConclusionsOur study found that TMB was a better predictor variable at evaluating the risk of PTC recurrence. Moreover, TMB-related genes conferred dramatically correlated prognosis, which was worth exploring in guiding postoperative follow-up and predicting recurrence for PTC patients.
Transient Thermal Analysis of a Solar-Assisted AHU by Focusing on Heat Recovery and Nanoparticles: Jeddah Climate Zone
Authors: Khetib Yacine 
Published: June 2021

In the Jeddah climate region, a lot of energy is assigned to the air handling unit (AHU) sector, which should be reduced by using energy-efficient solutions. As the air passes through the cooling coil, a lot of energy is consumed to reduce the temperature along with humidity so that if the air is precooled in the previous stages, energy consumption in this energy-intensive section will be diminished. Using the coldness of the return air in the heat recovery unit (HRU), the incoming air is precooled. Based on the thermodynamic calculations, in June, July, and August, the cooling coil power demand reduces by 11.6, 13.3, and 12%, respectively. In summer, owing to using HRU, an energy-saving by 76.08 MWh is achieved (12.34% reduction in energy demand). By the incorporation of the solar collectors in the AHU, heating coil demand diminishes by 1,206, 1,399, and 1,367 kWh in June, July, and August, respectively. To improve the solar-assisted AHU effectiveness, the MWCNT nanoparticles are injected into the collectors, and it is found that the saving-energy capability improves by 17.7% using MWCNT-water at 0.1 vol.%.
Boron Isotopic Analysis of Representative Atmospheric Aerosols Derived From Long-Range Transported/Local Emission on an Islet Offshore NE Taiwan
Authors: Lin Yen-Po , You Chen-Feng , Kao Tsung-Yu , Chung Chuan-Hsiung , Hung Chung-Chieh Gary 
Published: June 2021

To identify pollutant origins and their potential sources from either long-range transported (LRT) or local emissions, the Boron (B) concentrations and the B isotopic compositions (δ11B) in the water-soluble fraction of aerosols were determined. These aerosols were collected from an islet offshore in northeastern Taiwan, Peng Chia Yu (PCY), a non-residential islet, from January 1998 to March 2000. This islet may be influenced by various pollutants or chemical transport during monsoon periods, but suffers minimal human perturbation locally. The B in the specimens falls to 0.3–1.63 ng m−3 during the SW monsoon seasons when compared to 0.46–2.56 ng m−3 in the NE monsoon. However, the δ11B results show no clear variations in both monsoon seasons (10.7–24.3‰), regardless of differences in air mass origin. A two end-member mixing scenario is proposed to explain our observations using the obtained δ11B and 1/[B] results. The ocean endmember is characterized by high 1/[B] and high δ11B; while other endmember is from continental endmember or anthropogenic contributions that are characterized by of 1/[B] and lowδ11B (δ11B &lt; 10‰). Based on these chemical and isotopic results, we found aerosol emissions in northern Taiwan are characterized as low B with nearly constant δ11B, when compared with long-range transported continental endmembers derived from nearby regions. This study provides preliminary B and δ11B levels in aerosols derived from LRT/local emissions and discusses potential monsoonal effects on aerosols offshore of NE Taiwan.