bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Novel Peptide AEDPPE Alleviates Trophoblast Cell Dysfunction Associated With Preeclampsia by Regulating the NF-κB Signaling Pathway
Authors: Wang Yixiao , Cao Yan , Ji Xiaohong , Li Ting , Xue Lu , Li Chanjuan , Jia Ruizhe , Ding Hongjuan 
Published: December 2021

Background: Preeclampsia (PE) is a serious risk to the health of pregnant women and fetuses during pregnancy, and there is no effective treatment for this condition. Although many reports have confirmed the therapeutic effects of peptides in diseases, the role of peptides in PE remains poorly understood.Methods: A differentially expressed peptide in PE (AEDPPE) is derived from heat-shock protein beta-1 (HSPB1), amino acids 100 to 109 (DVNHFAPDEL), which we identified in a previous study. We synthesized AEDPPE and investigated its effect on HTR-8/SVneo cell function using a Cell Counting Kit-8, flow cytometric assay, and Transwell and wound-healing assays. Quantitative reverse transcription-PCR and ELISA were used to determine cytokine expression. Pull-down assay, mass spectrometry, Western blot analysis, and immunofluorescence were used to explore the potential targets and signaling pathways regulated by AEDPPE. Finally, we assessed the effect of AEDPPE in the lipopolysaccharide (LPS)-induced PE-like rat model.Results: AEDPPE significantly promoted the migration and invasion of HTR-8/SVneo cells, and it decreased the expression of interleukins 1 beta (IL-1β), interleukin 6 (IL-6), and interleukin 8 (IL-8). These functions performed by AEDPPE remained evident after injury to HTR-8/SVneo cells with tumor necrosis factor-alpha (TNF-α), and AEDPPE reversed the elevated sFlt-1/PlGF ratio induced by TNF-α. AEDPPE may exert these biological effects by binding to heat-shock protein 90β (HSP 90β) and, thus, affect the NF-κB signaling pathway. In an LPS-induced PE-like rat model, AEDPPE significantly improved PE symptoms and fetal rat outcomes.Conclusion: Our study showed that AEDPPE enhanced trophoblast migration and invasion and reduced inflammatory cytokine expression, and we hypothesized that these actions involved the NF-κB signaling pathway. The use of AEDPPE may thus develop into a novel modality in the treatment of PE.
Physical Activity, Sport Practice and Cardiovascular Risk Factors in Workers From a Public Hospital: A Trajectory Analysis
Authors: Marques Elias Rui Gonçalves , Ieker Ana Silvia Degasperi , Reis Lucas Lopes dos , Stabelini Neto Antônio , Sasaki Jeffer Eidi , Lopes Wendell Arthur , Costa Carla Eloise , Rinaldi Wilson 
Published: December 2021

Background: Studies have demonstrated the positive effects of physical activity on cardiovascular risk factors. Longitudinal studies using modeled trajectories are necessary to understand patterns of physical activity and association with cardiovascular risk factors.Objective: To analyze the association between sports practice in young people and current physical activity with the trajectory of cardiovascular risk factors in workers at a public hospital.Methods: Four hundred and seventeen workers was followed for four years reporting Physical Activity, health status, lifestyle behaviors and socio-demographic characteristics. Group-based trajectory modeling identified the trajectories of PA and associations with time-stable and time-varying covariates. We considered a range of sociodemographic and health and lifestyle factors as potential covariates.Results: The results shows the association between participation in sports activities in youth and current physical activity and trajectories of cardiovascular risk, adjusted for sex and age (p &lt; 0.05). Adults who reported having played sports in their youth and are currently active have a lower risk of having a history of obesity and low HDL-c than workers who did not play sports in their youth and are currently sedentary 0.690 (0.565–0.844) obesity, 0.647 (0.500–0.837) low HDL-c.Conclusion: The practice of sports in youth and current physical activity is a protective factor against the trajectory of obesity and low HDL-c, mainly in female workers. Programs to encourage the practice of physical activity should be carried out in order to reduce cardiovascular risk factors and prevent chronic diseases in workers.
Vitamin D and Lipid Profiles in Postmenopausal Women: A Meta-Analysis and Systematic Review of Randomized Controlled Trials
Authors: Liu Weiting , Wu Zezhen , Zhu Dan , Chen Genben , Yan Guiming , Zhang Shuo , Chen Fengwu , Khan Barkat Ali , Hou Kaijian 
Published: December 2021

Background and Aim: It is known that hyperlipidemia and low vitamin D level are risk factors associated with cardiovascular disease (CVD). However, the effect of vitamin D administration on lipid profiles in postmenopausal women remains unclear. This study aims to evaluate the effect of vitamin D on lipid profiles in postmenopausal women based on meta-analysis and systemic review.Methods: The literature search was performed in multiple databases (Scopus, PubMed/Medline, Web of Science, and Embase) from 1997 to 2021. The statistical analysis was performed using the Stata software version 14 (Stata Corp. College Station, Texas, United States). The effects of vitamin D administration of the lipid profiles, including Triacylglycerol (TG), LDL-Cholesterol (LDL-C), HDL-Cholesterol (HDL-C), and Total Cholesterol (TC) were evaluated by the Der Simonian and Laird random effects model. The weighted mean difference (WMD) and 95% confidence intervals (CI) were calculated.Results: The level of TG changed significantly by −3.76 mg/dl (CI: −6.12 to −1.39, p = 0.004) and HDL-C by 0.48 mg/dl (CI: −0.80 to −0.15, p = 0.004) in vitamin D administration group [11 eligible trials (placebo = 505 participants, vitamin D intervention = 604 participants)] compared to the control group in the postmenopausal women. Taking into account this comparison between groups, in contrast, the level of LDL-Cholesterol (LDL-C) (WMD: 0.73 mg/dl, 95% CI: −1.88, 3.36, p = 0.583) and TC (WMD: 0.689 mg/dl, CI: −3.059 to 4.438, p = 0.719) did not change significantly.Conclusion: In conclusion, the vitamin D administration in postmenopausal women, decreased the concentrations of TG, and HDL-C, but have no effects on LDL-C and TC.
Uniportal Video-Assisted Thoracoscopic Resection and Lobectomy for Infants With Pulmonary Sequestration: Case Series and Initial Experience
Authors: Huang Jin-Xi , Chen Qiang , Hong Song-Ming , Hong Jun-Jie , Cao Hua 
Published: December 2021

Background: The present study aimed to evaluate the safety and feasibility of uniportal video-assisted thoracoscopic surgery (U-VATS) for infants with pulmonary sequestration (PS).Methods: From January 2019 to July 2020, 19 infants with PS were admitted to a provincial hospital in the Fujian Province of China. A 1.5-cm utility port was created in the fifth intercostal space at the anterior axillary line. A rigid 30° 5-mm optic thoracoscope was used for vision, and two or three instruments were utilized through the port. Surgical options include standard lobectomy, wedge resection, and resection of the extralobar sequestration. Only one intercostal space was entered, and a chest tube was inserted through the same skin incision if necessary.Results: The procedure was successful in all patients with an average operation duration of 58.3 ± 31.5 min. The length of post-operative hospital stay was 5.4 ± 1.5 days, and no post-operative deaths or serious complications were observed. The mean post-operative drainage volume was 164.6 ± 45.9 mL, and the mean post-operative thoracic tube indwelling duration was 5.5 ± 1.0 days. No intraoperative conversion, surgical mortality, or major complications were identified among the patients.Conclusion: Our preliminary experience presented a series of U-VATS lobectomy, wedge resection, and resection of the PS for infants with satisfactory perioperative results.
Cerebral Oxygenation and Activity During Surgical Repair of Neonates With Congenital Diaphragmatic Hernia: A Center Comparison Analysis
Authors: Costerus Sophie A. , Hendrikx Dries , IJsselmuiden Joen , Zahn Katrin , Perez-Ortiz Alba , Van Huffel Sabine , Flint Robert B. , Caicedo Alexander , Wijnen René , Wessel Lucas , de Graaff Jurgen C. , Tibboel Dick , Naulaers Gunnar 
Published: December 2021

Background and aim: Neonatal brain monitoring is increasingly used due to reports of brain injury perioperatively. Little is known about the effect of sedatives (midazolam) and anesthetics (sevoflurane) on cerebral oxygenation (rScO2) and cerebral activity. This study aims to determine these effects in the perioperative period.Methods: This is an observational, prospective study in two tertiary pediatric surgical centers. All neonates with a congenital diaphragmatic hernia received perioperative cerebral oxygenation and activity measurements. Patients were stratified based on intraoperatively administrated medication: the sevoflurane group (continuous sevoflurane, bolus fentanyl, bolus rocuronium) and the midazolam group (continuous midazolam, continuous fentanyl, and continuous vecuronium).Results: Intraoperatively, rScO2 was higher in the sevoflurane compared to the midazolam group (84%, IQR 77–95 vs. 65%, IQR 59–76, p = &lt; 0.001), fractional tissue oxygen extraction was lower (14%, IQR 5–21 vs. 31%, IQR 29–40, p = &lt; 0.001), the duration of hypoxia was shorter (2%, IQR 0.4–9.6 vs. 38.6%, IQR 4.9–70, p = 0.023), and cerebral activity decreased more: slow delta: 2.16 vs. 4.35 μV2 (p = 0.0049), fast delta: 0.73 vs. 1.37 μV2 (p = &lt; 0.001). In the first 30 min of the surgical procedure, a 3-fold increase in fast delta (10.48–31.22 μV2) and a 5-fold increase in gamma (1.42–7.58 μV2) were observed in the midazolam group.Conclusion: Sevoflurane-based anesthesia resulted in increased cerebral oxygenation and decreased cerebral activity, suggesting adequate anesthesia. Midazolam-based anesthesia in neonates with a more severe CDH led to alarmingly low rScO2 values, below hypoxia threshold, and increased values of EEG power during the first 30 min of surgery. This might indicate conscious experience of pain. Integrating population-pharmacokinetic models and multimodal neuromonitoring are needed for personalized pharmacotherapy in these vulnerable patients.Trial Registration:https://www.trialregister.nl/trial/6972, identifier: NL6972.
Extensive Abdominal Skin Necrosis Following Anterior Component Separation for a Large Ventral Hernia: A Case Report
Authors: Bakula Branko , Sever Marko , Karačić Andrija , Bakula Mirko , Grbavac Martin , Romic Ivan , Bogut Ante , Zadro Zvonko 
Published: December 2021

Introduction: Hernia surgery is one of the most common operative procedures, performed in about 20 million cases per year all over the world, with ventral hernia accounting for about 30% of the cases. Although the introduction of the anterior component separation (ACS) method, popularized primarily by Oscar Ramirez, has greatly facilitated the closure of the largest abdominal wall defects, the 30-year experience in this technique has pointed to the risk of ischemic skin complications consequential to the major subcutaneous tissue dissection required. The aim of this case presentation of a patient who developed extensive necrosis of the abdominal wall skin following ACS procedure is to emphasize the importance of preserving rectus abdominis perforator blood vessels in order to preserve skin vitality.Case Presentation: We present a case of a 58-year-old female patient with a large recurrent ventral hernia. The hernial defect was closed by placing a large (30 × 25 cm) polypropylene mesh in the retro-rectus space using the Rives-Stoppa technique. To facilitate upper fascia closure ACS according to Ramirez was performed bilaterally. The rectus perforator vessels were not preserved. Recovery of the patient was complicated with the extensive abdominal skin necrosis which was successfully treated with negative pressure wound therapy.Discussion: Transection of the musculocutaneous perforators of the epigastric artery during ACS results with the compromised blood supply of the abdominal skin depending solely upon the intercostal arteries. Skin ischemia following ACS is a serious complication that can be presented with extensive necrosis associated with high morbidity and even mortality, while the treatment is long lasting, complex, and expensive. Considering the ever-increasing prevalence of large ventral hernias, ever greater popularity of the ACS technique, and the growing proportion of surgeons performing large ventral hernia operations independently, we think that the role of preserving perforated rectus vessels has not been emphasized enough. Therefore, the objective of this case study is to stimulate surgeons to preserve skin vascularity and promote it in their routine in order to avoid these severe postoperative complications.
Serum Tie-1 is a Valuable Marker for Predicting the Progression and Prognosis of Cervical Cancer
Authors: Bai Rui , Diao Bowen , Li Kaili , Xu Xiaohan , Yang Ping 
Published: December 2021

Objective: To investigate whether serum Tie-1 (sTie-1) is a valuable marker for predicting progression and prognosis of cervical cancer.Methods: Enzyme-linked immunosorbent assay (ELISA) was used to detect serum sTie-1 concentrations in 75 cervical cancer patients, 40 cervical intraepithelial neoplasia (CIN) patients, and 55 healthy controls without cervical lesions, and sTie-1 levels were compared between the groups. Receiver operating characteristic curves was used to evaluate the diagnostic value of sTie-1. The relationship between sTie-1 concentrations in patients with cervical cancer and clinicopathological features and prognosis were analyzed, and the risk factors for postoperative recurrence were determined using univariate and multivariable Cox proportional hazards regression.Results: We found that sTie-1 concentrations gradually increased according to lesion severity (i.e., cancer vs. CIN; p &lt; 0.05) and were significantly elevated in adenocarcinoma compared with healthy controls. sTie-1 levels strongly distinguished between cervical cancer patients and the healthy controls (area under the curve = 0.846; cut-off value = 1,882.64 pg/ml; sensitivity = 74.6%; specificity = 96.4%). Moreover, sTie-1 levels in cervical cancer patients were significantly associated with tumor size, advanced tumor stage, lymph node metastasis, and reduced 4-years progression-free survival. Cervical cancer patients with high sTie-1 concentrations had a 3.123-fold [95% confidence interval (CI): 1.087–8.971, p = 0.034] higher risk for tumor recurrence.Conclusions: Elevated sTie-1 levels in patients with cervical carcinoma were associated with tumor progression and poor prognosis, indicating that sTie-1 may be a valuable marker for predicting progression and prognosis of cervical cancer.
THE CONCEPT OF IOT SYSTEMS FOR AGRICULTURAL SERVICES WITH A HIGH DEGREE OF AUTONOMY
Authors: Хаджиева Л. К. , Хаджиев М. Р. , Исрахимова А. Т. 
Published: December 2021

В статье рассматриваются вопросы, связанные с использованием новейшей технологии IOT в сельском хозяйстве, показана основная роль Интернета вещей в сельском хозяйстве, которая заключается в том, чтобы можно было контролировать всю важную информацию благодаря оснащённому последними передовыми технологиями оборудованию. А также проанализированы возможности внедрения технологии IOT в агропромышленности, благодаря которой можно с легкостью отслеживать необходимые данные, такие как влажность, качество почвы, температура воздуха, также показаны возможности, которые появляются благодаря использованию дистанционных датчиков. Цель использования технологии, ее необходимость для повышения урожайности и планирования более результативной системы полива и составления прогнозов. Описана необходимость, технологии Интернета вещей в исследовании биологов, для воздействия геномов и микроклимата на степень урожайности, для возможного увеличения качества и производительности продукции. Идет описание вопросов касательно экологических проблем.
The article examines the issues related to the use of the latest IOT technology in agriculture, shows the main role of the Internet of Things in agriculture, which is to control all important information thanks to the equipment equipped with the latest advanced technologies. It also analyzed the possibilities of introducing IOT technology in the agricultural industry, thanks to which it is possible to easily track the necessary data, such as moisture, soil quality, air temperature, and also shows the possibilities that arise due to the use of remote sensors. The purpose of using the technology is its need for increasing yields and planning a more efficient irrigation system and making forecasts. The necessity of the Internet of Things technology in the study of biologists, for the influence of genomes and microclimate on the degree of productivity, for a possible increase in the quality and productivity of products is described. There is a description of questions regarding environmental issues.
mandatos de masculinidad en la cotidianeidad de la prisión
Authors: Marengo Malvina 
Published: December 2021

En este escrito, se toman aportes de los estudios de género y del psicoanálisis para analizar los efectos que tiene la institución penitenciaria como productora y reproductora de mandatos patriarcales, a partir del relato teórico y vivencial de algunos aspectos de la cotidianeidad de la vida en la prisión. Para ello, será fundamental contemplar cómo se construyen las masculinidades de quiénes habitan esos espacios (detenidos y agentes penitenciarios) y qué roles desempeñan los otros hombres y las mujeres, entendiendo que tanto la violencia como el ejercicio de poder se constituyen en elementos ineludibles para un análisis institucional. Finalmente, se abre el siguiente interrogante: si no se cuestionan las estructuras patriarcales, ¿es este un lugar eficaz para enfrentar y tratar la violencia machista?
Trabajo profesional de les trabajadores sociales en contexto de pandemia por COVID-19.
Authors: Escurra María Isabel 
Published: December 2021

Proponemos aproximarnos a caracterizar aspectos del trabajo profesional de les trabajadores sociales en el marco de la pandemia por COVID-19, específicamente durante el año 2020 y centrándonos en las posibilidades de construcción de autonomía profesional. Concibiendo la pausa reflexiva y colectiva como instancia necesaria para construir mayor autonomía profesional, pues el encuentro y el diálogo permiten compartir estrategias, imprimir direcciones y formas de encaminar colectivamente las intervenciones, resistencias y las luchas por la materialización de derechos. El recorte tempo-espacial señalado responde a los cambios en los procesos de trabajo en contexto de pandemia, sin desconocer cuestiones que van más allá de su irrupción. Por lo tanto intentamos esbozar aspectos centrales en torno a la crisis societal contemporánea, su relación con la pandemia y el trabajo profesional. Para abordar el tema propuesto, retomamos reflexiones de compañeras que se desempeñan en instituciones de salud de una ciudad media de la provincia de Buenos Aires y de Ciudad Autónoma de Buenos Aires en torno a: sus espacios socio profesionales, limitaciones, posibilidades y desafíos presentes. Dichas reflexiones fueron compartidas en el “Ciclo de Diálogos desde la experiencia en contextos de pandemia: Estado, Políticas Sociales y Prácticas profesionales. Realidades y desafíos”, convocado por las cátedras de Trabajo Social 1 y Estado y Política de Social de la Lic. en Trabajo Social, FCH, UNCPBA durante noviembre de 2020.
Defender la vida desde las trincheras:
Authors: Fernández Gonzalo Juan José 
Published: December 2021

En el presente texto se tematiza sobre los modos de organización comunitaria llevados adelante desde Villa Floresta, un Barrio Popular de Salta capital. Se tratará de describir y analizar los singulares modos que tienen las comunidades más pobres de hacer trinchera, en post de la subsistencia, como potencia para la defensa de la vida. Teniendo como trasfondo la ineluctable crisis por pandemia de COVID-19 y luego de haber transitado un tiempo de resistencias condicionadas por la depresión económica global que esta provocó, queremos “tomar el pulso”: la palabra y la acción de quienes habitan los barrios, para aproximar desde esos suelos, al horizonte de las luchas cotidianas que desarrollan las comunidades populares del norte de nuestro país. Nos interesa pensar las prácticas llevadas adelante en los barrios desde una analítica que se liga con el actual debate por desandar complejas tramas en torno a la asistencia como derecho. El tratamiento de este trabajo se desarrolla codificando prácticas discursivas y extra-discursivas: tanto de las personas que habitan los barrios, como de referentes de la administración del gobierno provincial; plasmadas en documentos periodísticos, consultando páginas del gobierno, programas y planes focalizados dirigidos a las poblaciones pobres.
Numerical analysis of optical phase modulator operating at 2 μm wavelength using graphene/III–V hybrid metal-oxide-semiconductor capacitor
Authors: Piyapatarakul Tipat , Tang Hanzhi , Toprasertpong Kasidit , Takagi Shinichi , Takenaka Mitsuru 
Published: December 2021

Abstract
We propose an optical phase modulator with a hybrid metal-oxide-semiconductor (MOS) capacitor, consisting of single-layer graphene and III–V semiconductor waveguide. The proposed modulator is numerically analyzed in conjunction with the surface conductivity model of graphene. Since the absorption of graphene at a 2 μm wavelength can be suppressed by modulating the chemical potential of graphene with the practical gate bias, the phase modulation efficiency is predicted to be 0.051 V·cm with a total insertion loss of 0.85 dB when an n-InGaAs waveguide is used, showing the feasibility of the low-loss, high-efficiency graphene/III–V hybrid MOS optical phase modulator, which is useful in the future 2 μm optical fiber communication band.
Verification of influence of tail states and interface states on sub-threshold swing of Si n-channel MOSFETs over a temperature range of 4–300 K
Authors: Kang Min-Soo , Toprasertpong Kasidit , Takenaka Mitsuru , Oka Hiroshi , Mori Takahiro , Takagi Shinichi 
Published: December 2021

Abstract
We experimentally characterize sub-threshold swing (SS) of Si n-channel MOSFETs with a substrate boron concentration of 2 × 1016 cm−3 as a function of drain current (I
DS) and temperatures from 4 to 300 K in order to verify the validity of the physical model of SS. The minimum SS are obtained experimentally at 4 K of around 4 mV dec−1. The physical model including mobile band tail states and localized interface states with a Gaussian distribution, proposed by Beckers at el., is employed to represent the experimental SS from 4 to 300 K. The impact of each parameter included in the physical model on the SS behavior is examined by changing the value of the parameters in simulation. It is found that the proposed physical model can quantitatively represent experimental SS in a wide range of I
DS and temperature under a given set of the parameters regarding the band tail states and the interface states. This finding indicates the validity of the present physical model and the correctness of the physical picture.
The exceptional advantages of channeling implantation into 4H-SiC to make abrupt deep profiles
Authors: Wada Ryota , Nagayama Tsutomu , Tokoro Nobuhiro , Kuroi Takashi , Das Hrishikesh , Sunkari Swapna , Justice Joshua 
Published: December 2021

Abstract
We investigated the channeling implantation of dopant ions into 4H-SiC in detail. The advantages of channeling implantation were clarified by both experimental and Monte Carlo simulation. Extremely abrupt deep profile with box-like can be formed by channeling implantation of Al and P ions. In the case of B and N ions, retrograde-like profile can be obtained by channeling implantation. The unique dopant profile can be realized by channeling implantation. Both vertical and lateral straggling becomes small by using channeling implantation for Al ions. This technique should contribute to improving the device performance such as gate pitch scaling and low specific on-resistance.