bluuebunny/crossref_metadata_2025_split huggingface dataset:
Testing a breast cancer prevention and a multiple disease prevention weight loss programme amongst women within the UK NHS breast screening programme—a randomised feasibility study
Authors: Harvie Michelle , French David P. , Pegington Mary , Cooper Grace , Howell Anthony , McDiarmid Sarah , Lombardelli Cheryl , Donnelly Louise , Ruane Helen , Sellers Katharine , Barrett Emma , Armitage Christopher J. , Evans D. Gareth 
Published: December 2021

Abstract
Background
Excess weight and unhealthy behaviours (e.g. sedentariness, high alcohol) are common amongst women including those attending breast screening. These factors increase the risk of breast cancer and other diseases. We tested the feasibility and acceptability of a weight loss/behaviour change programme framed to reduce breast cancer risk (breast cancer prevention programme, BCPP) compared to one framed to reduce risk of breast cancer, cardiovascular disease (CVD) and diabetes (T2D) (multiple disease prevention programme, MDPP).

Methods
Women aged 47-73 years with overweight or obesity (n = 1356) in the NHS Breast Screening Programme (NHSBSP) were randomised (1:2) to be invited to join a BCPP or a MDPP. The BCPP included personalised information on breast cancer risk and a web and phone weight loss/behaviour change intervention. The MDPP also included an NHS Health Check (lipids, blood pressure, HbA1c and personalised feedback for risk of CVD [QRISK2] and T2D [QDiabetes and HbA1c]). Primary outcomes were uptake and retention and other feasibility outcomes which include intervention fidelity and prevalence of high CVD and T2D risk. Secondary outcomes included change in weight.

Results
The BCPP and MDPP had comparable rates of uptake: 45/508 (9%) vs. 81/848 (10%) and 12-month retention; 33/45 (73%) vs. 53/81 (65%). Both programmes had a high fidelity of delivery with receipt of mean (95% CI) 90 (88-98% of scheduled calls, 91 (86-95%) of scheduled e-mails and 89 (76-102) website entries per woman over the 12-month period. The MDPP identified 15% of women with a previously unknown 10-year CVD QRISK2 of ≥ 10% and 56% with 10-year Qdiabetes risk of ≥ 10%. Both groups experienced good comparable weight loss: BCPP 26/45 (58%) and MDPP 46/81 (57%) with greater than 5% weight loss at 12 months using baseline observation carried forward imputation.

Conclusions
Both programmes appeared feasible. The MDPP identified previously unknown CVD and T2D risk factors but does not appear to increase engagement with behaviour change beyond a standard BCPP amongst women attending breast screening. A future definitive effectiveness trial of BCPP is supported by acceptable uptake and retention, and good weight loss.

Trial registration
ISRCTN91372184, registered 28 September 2014.
The effect of silicone oil tamponade on retinal layers and choroidal thickness in patients with rhegmatogenous retinal detachment: a systematic review and meta-analysis
Authors: Ghanbari Heshmatollah , Kianersi Farzan , Jamshidi Madad Alireza , Dehghani Alireza , Rahimi Alireza , Feizi Awat , Naderi Beni Afsaneh 
Published: December 2021

Abstract
Background
To evaluate the effects of intravitreal silicone oil (SO) on the retinal and choroidal thickness in eyes with rhegmatogenous retinal detachment (RRD).

Methods
A literature search was performed in Web of Science, Scopus, ProQuest, Embase, Clinical Key, Science Direct, Cochrane Library, and Springer, as well as Persian databases, including IranDoc, MagIran, SID, MOH thesis, and MOH articles until June 2020. Two reviewers independently searched and extracted the data.

Results
Sixteen studies (n = 391) met the inclusion criteria. The meta-analysis showed that the SO tamponade could significantly reduce the central macular thickness (CMT) in patients with RRD as compared to gas tamponade WMD = − 14.91; 95% CI: − 22.23, − 7.60; P < 0.001, I2 = 71%). No significant change was found in CMT between the eye with SO tamponade (after SO removal) and the fellow healthy eye in patients with RRD (WMD = − 3.52; 95% CI: − 17.63, 10.59; I2 = 68.6%). Compared to the preoperative stage, the SO tamponade could significantly reduce the subfoveal choroidal thickness in patients with RRD (WMD = − 18.67, 95% CI: − 30.07, − 1.28; I2 = 80.1%). However, there was no significant difference in the subfoveal choroidal thickness before and after SO removal (WMD = − 1.13, 95% CI: − 5.97, 3.71; I2 = 87.6%).

Conclusion
The SO tamponade had a significant effect on the reduction of retinal layers and the subfoveal choroidal thickness.
Characteristics of COVID and post COVID polyneuropathies in adults and pediatrics: an Egyptian sample
Authors: Elshebawy Haidy , Ezzeldin Mohamed Y. , Elzamarany Eman Hassan 
Published: December 2021

Abstract
Background
The aim of this study is to describe the different forms of polyneuropathy associated with coronavirus disease 2019 (COVID-19) as a secondary neurological complication for (COVID-19) and the outcome from different therapeutic regimens in adults and pediatrics in first and second waves of the pandemic.

Case presentation
This study was conducted on 42 patients, they were divided into two groups, group (A) and group (B) in first and second waves respectively. Twenty-five patients presented by ascending weakness preceded by fever, dry cough and respiratory distress, electromyography (EMG) and nerve conduction (NC) studies done and confirmed the clinical diagnosis of demyelinating polyneuropathy. Eight patients presented by acute flaccid quadriparesis, more severe in upper limbs preceded by fever and diarrhea diagnosed as acute axonal polyneuropathy. Five patients presented by severe fatigue and progressive weakness of both lower and upper limbs, they developed fever and cough 10 days after the neurological symptoms. EMG and NC done and confirmed clinical diagnosis of polyneuropathy of demyelinating with secondary axonal picture. Four patients presented 30 to 40 days after their recovery form corona virus infection with gradual progressive weakness of both upper and lower limbs over 2 to 3 months duration, mainly the proximal muscles of lower limbs were affected with areflexia. EMG and NC done and confirmed the diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP).

Conclusion
We should gain a better understanding of the underlying pathophysiology and therapeutic options of polyneuropathies related to COVID-19, which will have an impact on the treatment of the COVID related respiratory failure presenting with neuropathy.
Implementation factors for patient navigation program success: a qualitative study
Authors: Pratt-Chapman Mandi L. , Silber Rachel , Tang Jeffrey , Le Phuong Thao D. 
Published: December 2021

Abstract
Background
Patient navigation (PN) is an evidence-based practice that involves assessing and addressing individual barriers to care for patients. While PN has shown effectiveness in numerous studies, designing successful, sustainable PN programs has remained challenging for many healthcare organizations. The purpose of the present study was to examine implementation factors for successful PN programs to optimize the sustainability of PN services across cancer care settings in the USA.

Methods
Data were collected via semi-structured interviews with PN stakeholders (n=17) from diverse cancer care settings. Thematic content analysis was conducted by deductively coding major themes based on constructs from the Exploration-Preparation-Implementation-Sustainability framework and by inductively coding emergent themes.

Results
Facilitators in the outer context included payer guidelines, accreditation requirements, community partnerships, and demonstrated need and demand for services. Inner context factors such as alignment with organizational and leadership priorities, appropriate staff support and workloads, and relative advantage were important to program success. Innovation characteristics such as the presence of innovation champions, clear role and scope of practice, clear protocols, strong communication channels, and innovation fit were facilitators of program success. Community-Academic partnerships and funding stability also emerged as facilitators for program sustainability.

Conclusion
Our qualitative analysis from a diverse sample of PN stakeholders and programs across the USA supports intentional use of implementation theory to design PN programs to optimize implementation success.
ANGPT1 methylation and delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage patients
Authors: Liu Dongjing , Arockiaraj Annie I. , Shaffer John R. , Poloyac Samuel M. , Sherwood Paula R. , Alexander Sheila A. , Crago Elizabeth A. , Weeks Daniel E. , Conley Yvette P. 
Published: December 2021

Abstract
Background
Delayed cerebral ischemia (DCI) is a common secondary complication and an important cause of disability and mortality among patients who survive aneurysmal subarachnoid hemorrhage (aSAH). Knowledge on DCI pathogenesis, risk factors, and biomarkers are essential for early detection and improved prognosis. To investigate the role of DNA methylation in DCI risk, we conducted an epigenome-wide association study (EWAS) in 68 patients followed up to 1 year after the initial aneurysm rupture. Blood samples were collected within 48 h post hemorrhage and used for DNA methylation profiling at ~ 450k CpG sites. A separate cohort of 175 patients was sequenced for the top CpG sites from the discovery analysis for a replication of the EWAS findings.

Results
EWAS did not identify any epigenome-wide significant CpGs. The top signal, cg18031596, was annotated to ANGPT1, a gene with critical functions in angiogenesis after vascular injury. Post hoc power calculations indicated a well-powered discovery analysis for cg18031596. Analysis of the replication cohort showed that four out of the five CpG sites sequenced at the ANGPT1 locus passed a Bonferroni-adjusted significance threshold. In a pooled analysis of the entire sample, three out of five yielded a significant p-value, and the top association signal (p-value = 0.004) was seen for a CpG that was not originally measured in the discovery EWAS. However, four ANGPT1 CpG sites had an opposite effect direction in the replication analysis compared to the discovery EWAS, marking a failure of replication. We carefully examined this observed flip in directions and propose several possible explanations in addition to that it was a random chance that ANGPT1 ranked at the top in the discovery EWAS.

Conclusions
We failed to demonstrate a significant and consistent effect of ANGPT1 methylation in DCI risk in two cohorts. Though the replication attempt to weaken the overall support of this gene, given its relevant function and top rank of significance in the EWAS, our results call for future studies of larger aSAH cohorts to determine its relevance for the occurrence of DCI.
Memory and witness testimony: what the psychiatrist cannot know
Authors: Poole Norman A. 
Published: December 2021

SUMMARYPsychiatrists called on to assess the reliability of witness testimony in the courts enter an arena fraught with uncertainties. This commentary discusses Commane & Kopelman's exploration of both the ‘normal’ fallibility of memory and disordered memory and considers the unavoidable limitations of their guidance on memory assessment and medico-legal work.
Attention-deficit/hyperactivity disorder as a risk factor for dementia and mild cognitive impairment: A population-based register study
Authors: Dobrosavljevic Maja , Zhang Le , Garcia-Argibay Miguel , Du Rietz Ebba , Andershed Henrik , Chang Zheng , Faraone Stephen , Larsson Henrik 
Published: December 2021

AbstractBackgroundPrevious research has indicated that attention-deficit/hyperactivity disorder (ADHD) is associated with an increased risk for dementia, but studies are scarce and inconclusive. We aimed to investigate the association between ADHD, and dementia and mild cognitive impairment (MCI). Additionally, we aimed to investigate the impact of comorbid conditions, educational attainment, head injuries, other developmental disorders, and sex on the association.MethodsThe study population consisted of 3,591,689 individuals born between 1932 and 1963, identified from Swedish population-based registers. Cases of ADHD, dementia and MCI were defined according to ICD diagnostic codes and ATC codes for medication prescriptions. A Cox proportional hazards model was used to test the associations between ADHD, and dementia and MCI.ResultsIndividuals with ADHD had an increased risk for dementia and MCI. After adjusting for sex and birth year, a hazard ratio (HR) was 2.92 (95% confidence interval 2.40–3.57) for dementia, and 6.21 (5.25–7.35) for MCI. Additional adjustment for psychiatric disorders (depression, anxiety, substance use disorder, and bipolar disorder) substantially attenuated the associations, HR = 1.62 (1.32–1.98) for dementia, and 2.54 (2.14–3.01) for MCI. Common metabolic disorders (hypertension, type 2 diabetes, and obesity), sleep disorders, head injuries, educational attainment, and other developmental disorders, had a limited impact on the association. The association between ADHD and dementia was stronger in men.ConclusionsADHD is a potential risk factor for dementia and MCI, although the risk significantly attenuates after controlling for psychiatric disorders. Further research is needed to confirm these findings and to explore underlying mechanisms of the associations.
Secretin Stimulation Test and Early Diagnosis of Gastrinoma in MEN1 Syndrome: Survey on the MEN1 Florentine Database
Authors: Giusti Francesca , Cioppi Federica , Fossi Caterina , Marini Francesca , Masi Laura , Tonelli Francesco , Brandi Maria Luisa 
Published: December 2021

AbstractContextMultiple endocrine neoplasia type 1 (MEN1) is a rare inherited endocrine cancer syndrome. Multiple gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) affect 30% to 80% of MEN1 patients, with the most common functioning GEP-NET being gastrinoma. Biochemical identification of hypergastrinemia may help to recognize the presence of gastrinomas before they are detectable by instrumental screening, enabling early diagnosis and start of therapy, preferably before tumor progression and metastases occurrence.ObjectiveEvaluate the effectiveness of secretin stimulation test to precociously diagnose the presence of gastrin-secreting tumors.DesignResults of secretin stimulation tests, performed between 1991 and February 2020, were retrospectively analyzed, as aggregate, in a cohort of MEN1 patients with GEP-NETs.SettingData were extracted from the MEN1 Florentine database.PatientsThe study included 72 MEN1 patients with GEP-NETs who underwent a secretin stimulation test for the evaluation of gastrin secretion.OutcomesA positive secretin stimulation test was assumed with a difference between basal fasting serum gastrin (FSG) and the maximum stimulated value of gastrin over 120 pg/mL.ResultsThe secretin stimulation test showed a secretin-induced hypergastrinemia in 27.8% (20/72) of patients with GEP-NETs, and a positive test in 18 cases. The test allowed the identification of a positively stimulated hypergastrinemia in 75.0% (3/4) of patients who presented a basal FSG within the normal range.ConclusionsDiagnosis of gastrinoma is complex, difficult, and controversial. Results of this study confirm that a positive secretin stimulation test allows early diagnosis of gastrinomas, even in the presence of borderline or normal levels of nonstimulated FSG.
Protocol for an exploratory, longitudinal single case study of a novel palliative care rehabilitative service
Authors: Ní Chéileachair Fódhla N. , Johnston Bridget M. , Payne Cathy , Cahill Fiona , Mannion Lisa , McGirr Lisa , Ryan Karen 
Published: December 2021

Background: Early access to rehabilitation can improve quality of life for those with life-limiting illnesses and is highlighted as a core component of the Adult Palliative Care Services Model of Care for Ireland. Despite this, palliative rehabilitation remains under-utilised and under-developed. In 2020, the Sláintecare Integration Fund provided opportunity to pilot a novel rehabilitative palliative care service, “Palliat Rehab”. This protocol proposes a case study, which aims to advance understanding of the form, content, and delivery of the pilot service. Methods: A prospective, longitudinal, mixed-methods, case study design will be used to describe the service and to explore the experiences of patients, informal carers and clinicians. Additionally, data collection instruments will be tested and the utility of outcome measures will be examined. Data will be collected from documentary, survey, and interview sources. Quantitative data will be analysed using descriptive statistics, including chi-square tests for categorical variables, Mann-Whitney U tests for ordinal data, and t-tests/ ANOVA for continuous data. Qualitative data will be analysed using thematic analysis. Conclusions: New pathways are required to advance service provision to ensure that patients receive the ‘right care, in the right place, at the right time’. The development of ‘‘Palliat Rehab’’ offers opportunity to study an innovative service and consider its potential contribution to the achievement of Sláintecare goals. Investigating the service within its environmental context will lead to a better understanding of ‘how’ and ‘why’ things happen. Findings will be of value in assessing whether there is evidence that supports the service, and will be used to inform efforts to further develop and tailor the intervention.
Government plans in the 2016 and 2021 Peruvian presidential elections: A natural language processing analysis of the health chapters
Authors: Carrillo-Larco Rodrigo M. , Castillo-Cara Manuel , Lovón-Melgarejo Jesús 
Published: December 2021

Background:While clinical medicine has exploded, electronic health records for Natural Language Processing (NLP) analyses, public health, and health policy research have not yet adopted these algorithms. We aimed to dissect the health chapters of the government plans of the 2016 and 2021 Peruvian presidential elections, and to compare different NLP algorithms.Methods:From the government plans (18 in 2016; 19 in 2021) we extracted each sentence from the health chapters. We used five NLP algorithms to extract keywords and phrases from each plan: Term Frequency–Inverse Document Frequency (TF-IDF), Latent Dirichlet Allocation (LDA), TextRank, Keywords Bidirectional Encoder Representations from Transformers (KeyBERT), and Rapid Automatic Keywords Extraction (Rake).Results:In 2016 we analysed 630 sentences, whereas in 2021 there were 1,685 sentences. The TF-IDF algorithm showed that in 2016, 22 terms appeared with a frequency of 0.05 or greater, while in 2021 27 terms met this criterion. The LDA algorithm defined two groups. The first included terms related to things the population would receive (e.g., ’insurance’), while the second included terms about the health system (e.g., ’capacity’). In 2021, most of the government plans belonged to the second group. The TextRank analysis provided keywords showing that ’universal health coverage’ appeared frequently in 2016, while in 2021 keywords about the COVID-19 pandemic were often found. The KeyBERT algorithm provided keywords based on the context of the text. These keywords identified some underlying characteristics of the political party (e.g., political spectrum such as left-wing). The Rake algorithm delivered phrases, in which we found ’universal health coverage’ in 2016 and 2021.Conclusion:The NLP analysis could be used to inform on the underlying priorities in each government plan. NLP analysis could also be included in research of health policies and politics during general elections and provide informative summaries for the general population.
Lutsi speakers and rememberers in the late 20th and early 21st centuries
Authors: Balodis Uldis 
Published: December 2021

This article describes the language of the last speakers of Lutsi as well as their family background and the sources of their language knowledge, in order to show the paths by which Lutsi language knowledge – even if only of a fragmentary sort – has survived up to the present day. The language knowledge of these last speakers is described using observations taken from the field notes and memories of other researchers as well as from my own encounters with them. This information is placed in a historical and regional context by providing a detailed overview of the historical extent of the Lutsi community, theories about Lutsi origins and how this connects with the memory of Lutsi families and observed language variation within the Lutsi speech area, changes in Lutsi speaker numbers and language use, and the history of Lutsi documentation and the observations of the researchers who documented them.
Kokkuvõte. Uldis Balodis: Lutsi keele kõnelejad ja mäletajad 20. ja 21. sajandi vahetusel. Lutsi keelt räägiti mitu sajandit Kagu-Lätis Ludza linna ümbritsevates valdades ja külades. Lutsi keel ja kultuur said tähtsaks osaks nii Latgali kui ka kogu Läti kultuuriajaloost. Lutsi keel on ühendanud Eestit ja Lätit ning saanud nende ühise pärandi sümboliks. Selle artikli esimeses osas kirjeldatakse lutsi keele uurijate (Oskar Kallas, Heikki Ojansuu, Paulopriit Voolaine, August Sang) mälestusi ja tähelepanekuid ajast, kui seda keelt veel räägiti igapäevaselt. Artikli teises osas antakse ülevaate Põlda valla Jaani küla Nikonovide perekonnast, kes olid viimaseid lutsi keele oskajaid. Samuti vaadeldakse viimaseid lutsi keelepärandi kandjaid tänapäeval – nn mäletajaid –, käsitledes nii nende elulugusid kui ka teadmisi lutsi keelest.
Kokkovyteq Lutsi kielehn. Uldis Balodis: Lutsi kiele kynelejaq ni mälehäjäq 20. ni 21. sā-āstaga vaihtusel. Mitu sā-āstakka kyneldi lutsi kīlt Ludzi ümbre valdohn ni küllihn. Lutsi kīļ um nī Lätkalihn ku kaq kȳ Lätihn kultūri aolū tähtsä oza. Lutsi kīļ um kaq tähtsä köüdüs Läti ni Ēstimā vaihel ni noide ütidze perändüze tunnismärķ. Sjōl kirotuzel um katș ossa. Edimädzehn ozahn ma selledä lutsi kiele ūŗjide (Oskar Kallas, Heikki Ojansuu, Paulopriit Voolaine, August Sang) mälehüizi ni tähelepandmizi aost, ku tūd kīlt vīl egä päiv kyneldi. Tȳz̦ ehn ozahn tī ülekaehuze Pylda valla Jāni külä Nikonovi perrest, kohn elliq perämädze lutsi kiele myistjaq. Ma ka kynele perämädzist Lutsi inemizist tǟmbädzel pǟväl – nm mälehäjidest –, kiä viļ tīdväq veidüq lutsi kīlt, ni kaq noide elolūst ni kiele tīdmizest.
Sociocultural Functional Literacy As a Planned Learning Outcome of a Primary Schoolchild
Authors: Fedorova N. 
Published: December 2021

The article highlights the problem of the formation of socio-cultural literacy in a junior schoolchild, which is considered as the planned result
of his education in primary school. The characteristic of the concept of “socio-cultural literacy” is given, the difficulties of the formation of its
individual components are discussed: civic identity; legal and financial culture; tolerance, etc. The examples of methods and techniques aimed at the development of socio-cultural literacy are given, the expediency of using different forms of organization of education is revealed, which contributes to the formation of the ability of primary schoolchildren to constructively build relationships in children’s society and successfully interact.