bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-negative Martingale Solutions to the Stochastic Thin-Film Equation with Nonlinear Gradient Noise
Authors: Dareiotis Konstantinos , Gess Benjamin , Gnann Manuel V. , Grün Günther 
Published: July 2021

AbstractWe prove the existence of non-negative martingale solutions to a class of stochastic degenerate-parabolic fourth-order PDEs arising in surface-tension driven thin-film flow influenced by thermal noise. The construction applies to a range of mobilites including the cubic one which occurs under the assumption of a no-slip condition at the liquid-solid interface. Since their introduction more than 15 years ago, by Davidovitch, Moro, and Stone and by Grün, Mecke, and Rauscher, the existence of solutions to stochastic thin-film equations for cubic mobilities has been an open problem, even in the case of sufficiently regular noise. Our proof of global-in-time solutions relies on a careful combination of entropy and energy estimates in conjunction with a tailor-made approximation procedure to control the formation of shocks caused by the nonlinear stochastic scalar conservation law structure of the noise.
Stoichiometric Modeling of Artificial String Chemistries Reveals Constraints on Metabolic Network Structure
Authors: Moyer Devlin , Pacheco Alan R. , Bernstein David B. , Segrè Daniel 
Published: July 2021

AbstractUncovering the general principles that govern the structure of metabolic networks is key to understanding the emergence and evolution of living systems. Artificial chemistries can help illuminate this problem by enabling the exploration of chemical reaction universes that are constrained by general mathematical rules. Here, we focus on artificial chemistries in which strings of characters represent simplified molecules, and string concatenation and splitting represent possible chemical reactions. We developed a novel Python package, ARtificial CHemistry NEtwork Toolbox (ARCHNET), to study string chemistries using tools from the field of stoichiometric constraint-based modeling. In addition to exploring the topological characteristics of different string chemistry networks, we developed a network-pruning algorithm that can generate minimal metabolic networks capable of producing a specified set of biomass precursors from a given assortment of environmental nutrients. We found that the composition of these minimal metabolic networks was influenced more strongly by the metabolites in the biomass reaction than the identities of the environmental nutrients. This finding has important implications for the reconstruction of organismal metabolic networks and could help us better understand the rise and evolution of biochemical organization. More generally, our work provides a bridge between artificial chemistries and stoichiometric modeling, which can help address a broad range of open questions, from the spontaneous emergence of an organized metabolism to the structure of microbial communities.
MRI features of ERSA (exercise-related signal abnormality) lesions in professional soccer players
Authors: Kho James S. B. , Botchu Rajesh , Rushton Alison , James Steven L. 
Published: July 2021

Abstract
Objective
This study aims to describe the prevalence, anatomy and morphology of ERSA (exercise-related signal abnormality) lesions, a previously undescribed pattern of muscle signal changes on MRI in professional soccer players with suspected acute thigh muscle injury.

Methods
A multicenter retrospective review was performed of 287 MRIs of professional soccer players referred for suspected acute thigh injury from August 2017 to February 2020. MR images were reviewed for muscle signal abnormalities corresponding to a peritendinous ovoid region or a subfascial ring of faint increased signal on fluid-sensitive MR images. Imaging features including anatomical site, morphology, and craniocaudal length were recorded. Concomitant acute muscle injury was graded in accordance with the British Athletics Muscle Injury Classification (BAMIC).

Results
ERSA lesions comprising a peritendinous ovoid region, a subfascial ring, or both, were identified in 40 muscles across 31/287 studies (10.8%). These lesions had a mean length of 15.8 cm and were predominantly located in the proximal or mid-portions of muscles. Affected muscles were rectus femoris (n = 22), adductor longus (n = 11), semitendinosus (n = 6) and biceps femoris (n = 1). 21/31 studies (67.7%) had a BAMIC grade 1–4 injury in a separate muscle, which were largely (81%) in a separate anatomic compartment or contralateral.

Conclusion
ERSA lesions were evident on MRI in 10.8% of our cohort of professional soccer players referred for suspected acute thigh muscle injury. Characteristic morphology and the longitudinal length (mean 15.8 cm) distinguish ERSA lesions from recognized patterns of acute muscle injury.
Hyaluronic Acid Fillers Enriched with Glycine and Proline in Eyebrow Augmentation Procedure
Authors: Scarano Antonio , Rapone Biagio , Amuso Domenico , Inchingolo Francesco , Lorusso Felice 
Published: July 2021

Abstract
Background
The eyebrow area is a clinically critical district due to the anatomical complexity and the propensity to aging-related atrophy. Hyaluronic acid fillers have been proposed to recover the dermal volume of the facial and lips regions.

Aim
The aim of the present investigation was to evaluate hyaluronic acid fillers enriched with glycine and proline for the treatment of eyebrow augmentation.

Methods
A total of 15 healthy patients were treated with eyebrow augmentation procedure. The distance between mid-bipupil to lateral eyebrow and mid-eyebrow to the medial eyebrow was measured before, immediately after treatment and at follow-up of 6 months.

Results
The healing period was uneventful, and no evidence of inflammation or swelling associated with the treatment was reported. No macroscopical alteration was reported in the surrounding tissues with no evidences of visible wheals or lumps in the treated sites at the follow-up. Before treatment, the angle was equal to 9.32 ± 0.2°, while after treatment it was 11.21 ± 0.4° (p < 0.01); after three and 6 weeks, it was, respectively, 10.66 ± 0.2° (p<0.05) and 10.02 ± 0.3°(p > 0.05).

Conclusions
The study results suggest that the hyaluronic acid fillers enriched with glycine and proline treatment resulted as being a useful procedure for augmentation, contour and volume definition and elevation of the eyebrow region with a high-level aesthetic result.

Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
CIRSE Clinical Practice Manual
Authors: Mahnken Andreas H. , Boullosa Seoane Esther , Cannavale Allesandro , de Haan Michiel W. , Dezman Rok , Kloeckner Roman , O’Sullivan Gerard , Ryan Anthony , Tsoumakidou Georgia 
Published: July 2021

Abstract
Background
Interventional radiology (IR) has come a long way to a nowadays UEMS-CESMA endorsed clinical specialty. Over the last decades IR became an essential part of modern medicine, delivering minimally invasive patient-focused care.

Purpose
To provide principles for delivering high quality of care in IR.

Methods
Systematic description of clinical skills, principles of practice, organizational standards and infrastructure needed for the provision of professional IR services.

Results
There are IR procedures for almost all body parts and organs, covering a broad range of medical conditions. In many cases IR procedures are the mainstay of therapy, e.g. in the treatment of hepatocellular carcinoma. In parallel the specialty moved from the delivery of a procedure towards taking care for a patient’s condition with the interventional radiologists taking ultimate responsibility for the patient’s outcomes.

Conclusions
The evolution from a technical specialty to a clinical specialty goes along with changing demands on how clinical care in IR is provided. The CIRSE Clinical Practice Manual provides interventional radiologist with a starting point for developing his or her IR practice as a clinician.
Complex network approach for detecting tropical cyclones
Authors: Gupta Shraddha , Boers Niklas , Pappenberger Florian , Kurths Jürgen 
Published: July 2021

AbstractTropical cyclones (TCs) are one of the most destructive natural hazards that pose a serious threat to society, particularly to those in the coastal regions. In this work, we study the temporal evolution of the regional weather conditions in relation to the occurrence of TCs using climate networks. Climate networks encode the interactions among climate variables at different locations on the Earth’s surface, and in particular, time-evolving climate networks have been successfully applied to study different climate phenomena at comparably long time scales, such as the El Niño Southern Oscillation, different monsoon systems, or the climatic impacts of volcanic eruptions. Here, we develop and apply a complex network approach suitable for the investigation of the relatively short-lived TCs. We show that our proposed methodology has the potential to identify TCs and their tracks from mean sea level pressure (MSLP) data. We use the ERA5 reanalysis MSLP data to construct successive networks of overlapping, short-length time windows for the regions under consideration, where we focus on the north Indian Ocean and the tropical north Atlantic Ocean. We compare the spatial features of various topological properties of the network, and the spatial scales involved, in the absence and presence of a cyclone. We find that network measures such as degree and clustering exhibit significant signatures of TCs and have striking similarities with their tracks. The study of the network topology over time scales relevant to TCs allows us to obtain crucial insights into the effects of TCs on the spatial connectivity structure of sea-level pressure fields.
Potenziale und Herausforderungen von sozialen Robotern für Beziehungen älterer Menschen: eine Bestandsaufnahme mittels „rapid review“
Authors: Zöllick Jan C. , Rössle Susanna , Kluy Lina , Kuhlmey Adelheid , Blüher Stefan 
Published: July 2021

ZusammenfassungHintergrundSoziale Beziehungen sind bedeutsame Ressourcen für psychisches Wohlbefinden und physische Gesundheit. Im höheren Lebensalter treffen zunehmende Vulnerabilität und Funktionsverluste häufig auf reduzierte soziale Netzwerke. Mangelnde soziale Kontakte und fehlende Netzwerke bergen dabei psychische und physische Risiken für die Betroffenen, die durch den Einsatz sozialer Roboter möglicherweise abgemildert werden können.FragestellungWelche Potenziale und Herausforderungen ergeben sich für ältere Menschen aus ihrer Interaktion mit sozialen Robotern?Material und MethodenDie Forschungsfrage wird mittels eines „rapid review“ beantwortet. Eine systematische Literatursuche ergab 433 unikale Treffer, aus denenn = 11 Artikel in die Analysen eingingen.ErgebnissePotenziale sozialer Roboter bestehen in der Reduktion von Einsamkeit, Stärkung der (zwischenmenschlichen) Kommunikation und Stimmungsaufhellung bei gleichzeitiger Stressreduktion. Herausforderungen bestehen in der sozialen Einbettung der Roboter. Diese sei durch Aspekte wie Wohltätigkeit, Autonomie und Privatheit als Grundsätze zu gestalten, an denen sich Design und Einsatz von sozialen Robotern orientieren können, um einem Verlust von sozialen Beziehungen vorzubeugen.DiskussionDie Ergebnisse zeigen einen Korridor auf, der die potenzialausschöpfende Anwendung sozialer Roboter für ältere Menschen ermöglicht. Im Vordergrund steht die Analyse der Herausforderungen für den Einzelfall, da soziale Beziehungen älterer Menschen positiv sowie negativ beeinflusst werden können. Dabei orientieren sich die eingeschlossenen Artikel größtenteils am Setting Pflege. Forschung zum Einsatz sozialer Roboter bei nicht oder wenig funktionseingeschränkten Personen sollte die bestehende Literatur ergänzen.
The (pro)renin receptor (ATP6ap2) facilitates receptor-mediated endocytosis and lysosomal function in the renal proximal tubule
Authors: Figueiredo Marta , Daryadel Arezoo , Sihn Gabin , Müller Dominik N. , Popova Elena , Rouselle Anthony , Nguyen Genevieve , Bader Michael , Wagner Carsten A. 
Published: July 2021

AbstractThe ATP6ap2 (Pro)renin receptor protein associates with H+-ATPases which regulate organellar, cellular, and systemic acid–base homeostasis. In the kidney, ATP6ap2 colocalizes with H+-ATPases in various cell types including the cells of the proximal tubule. There, H+-ATPases are involved in receptor-mediated endocytosis of low molecular weight proteins via the megalin/cubilin receptors. To study ATP6ap2 function in the proximal tubule, we used an inducible shRNA Atp6ap2 knockdown rat model (Kd) and an inducible kidney-specific Atp6ap2 knockout mouse model. Both animal lines showed higher proteinuria with elevated albumin, vitamin D binding protein, and procathepsin B in urine. Endocytosis of an injected fluid-phase marker (FITC- dextran, 10 kDa) was normal whereas processing of recombinant transferrin, a marker for receptor-mediated endocytosis, to lysosomes was delayed. While megalin and cubilin expression was unchanged, abundance of several subunits of the H+-ATPase involved in receptor-mediated endocytosis was reduced. Lysosomal integrity and H+-ATPase function are associated with mTOR signaling. In ATP6ap2, KO mice mTOR and phospho-mTOR appeared normal but increased abundance of the LC3-B subunit of the autophagosome was observed suggesting a more generalized impairment of lysosomal function in the absence of ATP6ap2. Hence, our data suggests a role for ATP6ap2 for proximal tubule function in the kidney with a defect in receptor-mediated endocytosis in mice and rats.
Intra-abdominal EWSR1/FUS-CREM-rearranged malignant epithelioid neoplasms: two cases of an emerging aggressive entity with emphasis on misleading immunophenotype
Authors: Agaimy Abbas , Stoehr Robert , Otto Mike , Bräsen Jan Hinrich , Pfarr Nicole , Konukiewitz Björn , Kasajima Atsuko , Hartmann Arndt , Klöppel Günter 
Published: July 2021

AbstractCREB family (CREB1, ATF1, and CREM) gene fusions are defining markers in diverse mesenchymal neoplasms (clear cell sarcoma, angiomatoid fibrous histiocytoma, and others). However, neoplasms harboring EWSR1-CREM/FUS-CREM fusions are rare and poorly characterized. We describe two cases (55-year-old male with 7.5 cm renal mass and 32-year-old female with 5.5 cm mesenteric mass) illustrating their misleading immunophenotypes. Histologically, both showed eosinophilic and focally clear epithelioid cells arranged into sheets, nests, and trabeculae. Immunohistochemistry showed ALK, EMA, and AE1/AE3 immunoreactivity suggesting ALK-rearranged renal cell carcinoma (Case 1) and coexpression of keratin, EMA, synaptophysin, and chromogranin-A, suggesting neuroendocrine neoplasm (Case 2). Targeted RNA sequencing revealed EWSR1-CREM (Case 1) and FUS-CREM (Case 2) fusions. These cases add to the spectrum of CREM fusion-positive intra-abdominal epithelioid neoplasms. Their unusual immunophenotype and unexpected sites represent major pitfalls, underline a wide differential diagnosis, and emphasize the value of molecular testing in correctly diagnosing them.
Linguistic methods in healthcare application and COVID-19 variants classification
Authors: Ogiela Marek R. , Ogiela Urszula 
Published: July 2021

AbstractOne of the most important goals of modern medicine is prevention against pandemic and civilization diseases. For such tasks, advanced IT infrastructures and intelligent AI systems are used, which allow supporting patients’ diagnosis and treatment. In our research, we also try to define efficient tools for coronavirus classification, especially using mathematical linguistic methods. This paper presents the ways of application of linguistics techniques in supporting effective management of medical data obtained during coronavirus treatments, and possibilities of application of such methods in classification of different variants of the coronaviruses detected for particular patients. Currently, several types of coronavirus are distinguished, which are characterized by differences in their RNA structure, which in turn causes an increase in the rate of mutation and infection with these viruses.
On infinite groups in which all abelian subgroups are locally cyclic
Authors: Delizia Costantino , Nicotera Chiara 
Published: July 2021

AbstractThe structure of locally soluble periodic groups in which every abelian subgroup is locally cyclic was described over 20 years ago. We complete the aforementioned characterization by dealing with the non-periodic case. We also describe the structure of locally finite groups in which all abelian subgroups are locally cyclic.
The impact of preschool child and maternal attention-deficit/hyperactivity disorder (ADHD) symptoms on mothers’ perceived chronic stress and hair cortisol
Authors: Szép Anna , Skoluda Nadine , Schloß Susan , Becker Katja , Pauli-Pott Ursula , Nater Urs M. 
Published: July 2021

AbstractProviding care for a child with attention-deficit/hyperactivity disorder (ADHD) is associated with parenting stress. Moreover, adults with elevated ADHD symptoms report increased perceived stress. Despite this, it has rarely been examined whether and how child and maternal ADHD symptoms may affect maternal perceived stress and the stress-sensitive hypothalamic–pituitary–adrenal axis. This study therefore investigated the possible impact of child and maternal ADHD symptoms on mothers' perceived chronic stress and hair cortisol concentration (HCC), while simultaneously considering the effects of child oppositional defiant/conduct disorder (ODD/CD) and maternal depressive symptomatology. In total, 124 mothers (35.96 ± 5.21 years) of preschool children were included. Maternal perceived stress, ADHD and depressive symptoms were assessed using self-report measures. Child ADHD symptoms were assessed using an interview and questionnaires completed by mothers and teachers. Additionally, mothers provided information about their children’s ODD/CD symptoms. Hair samples were taken from mothers to assess HCC. Child and maternal ADHD, child ODD/CD, and maternal depressive symptoms accounted for 50% of the variance in perceived chronic stress (F(4, 119) = 30.24; p < 0.01), with only maternal ADHD (β = 0.52, p < 0.01) and depressive symptoms (β = 0.49, p < 0.01) being uniquely significant. Maternal ADHD symptoms did not moderate the relationship between child ADHD symptoms and maternal perceived chronic stress (b = − 0.01; SE b = 0.17; t(5, 118) = − 0.05; p = 0.96). Mother’s age became the only significant predictor of maternal HCC (β = 0.29; p < 0.01). Based on these findings, practitioners are advised to be aware of and take into account possible maternal ADHD and depressive symptomatology and perceived chronic stress when treating children diagnosed with ADHD.
Facial emotion recognition in adopted children
Authors: Paine Amy L. , van Goozen Stephanie H. M. , Burley Daniel T. , Anthony Rebecca , Shelton Katherine H. 
Published: July 2021

AbstractChildren adopted from public care are more likely to experience emotional and behavioural problems. We investigated two aspects of emotion recognition that may be associated with these outcomes, including discrimination accuracy of emotions and response bias, in a mixed-method, multi-informant study of 4-to-8-year old children adopted from local authority care in the UK (N = 42). We compared adopted children’s emotion recognition performance to that of a comparison group of children living with their birth families, who were matched by age, sex, and teacher-rated total difficulties on the Strengths and Difficulties Questionnaire (SDQ, N = 42). We also examined relationships between adopted children’s emotion recognition skills and their pre-adoptive histories of early adversity (indexed by cumulative adverse childhood experiences), their parent- and teacher-rated emotional and behavioural problems, and their parents’ coded warmth during a Five Minute Speech Sample. Adopted children showed significantly worse facial emotion discrimination accuracy of sad and angry faces than non-adopted children. Adopted children’s discrimination accuracy of scared and neutral faces was negatively associated with parent-reported behavioural problems, and discrimination accuracy of angry and scared faces was associated with parent- and teacher-reported emotional problems. Contrary to expectations, children who experienced more recorded pre-adoptive early adversity were more accurate in identifying negative emotions. Warm adoptive parenting was associated with fewer behavioural problems, and a lower tendency for children to incorrectly identify faces as angry. Study limitations and implications for intervention strategies to support adopted children’s emotion recognition and psychological adjustment are discussed.
A simple approach to dynamic material balance for a dry-gas reservoir
Authors: Jongkittinarukorn Kittiphong , Last Nick , Jokhio Sarfaraz Ahmed , Escobar Freddy Humberto , Chewaroungroaj Jirawat 
Published: July 2021

AbstractThe dynamic material balance methodology can be used to estimate gas initially-in-place using only production and PVT data. With this methodology, reservoir pressure is obtained without requiring the well to be shut in; it is therefore superior to the static material balance method since there is no loss of production. However, the technique requires iterative calculations and numerical integration of gas pseudotime and is quite complex to implement in practice. A simpler and equally accurate methodology is proposed in this study. It requires only production and PVT data and also does not rely on a shut-in pressure survey. In addition, it requires neither iterative calculations nor numerical integration of gas pseudotime. The results of the analysis include gas initially-in-place and gas productivity index, and can easily be extended to production forecasting. Gas initially-in-place is evaluated with a high degree of reliability. The methodology is successfully tested with two simulated cases and one field case, giving high-accuracy results.