bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sharing information about health‐related resources: Observations from a community resource referral intervention trial in a predominantly African American/Black community
Authors: Lindau Stacy Tessler , Makelarski Jennifer A. , Abramsohn Emily M. , Beiser David G. , Boyd Kelly , Huang Elbert S. , Paradise Kelsey , Tung Elizabeth L. 
Published: July 2021

AbstractCommunityRx is a theory‐driven, information technology‐based intervention, developed with and in a predominantly African American/Black community, that provides patients with personalized information (a “HealtheRx”) about self‐management and social care resources in their community. We described patient and clinician information sharing after exposure to the intervention during a clinical trial. Survey data from 145 patients (ages 45–74) and 121 clinicians were analyzed. Of patients who shared information at least once (49%), 47% reported sharing ≥3 times (range 1–14). Patient sharers were in poorer physical health (mean PCS 37.6 vs. 40.8, p = .05) than nonsharers and more likely to report going to a resource on their HealtheRx (79 vs. 41%, p ≤ .05). Most patient sharers provided others a look at or copy of their HealtheRx, keeping the original. Patients used the HealtheRx to promote credibility of the information and communicate that resources were disease‐specific and local. Half of clinicians shared HealtheRx resource information with peers; sharers were 3 times more likely than nonsharers to feel they were well‐informed about resources to address social needs (55 vs. 18%, p < .01). Information sharing by clinicians and patients is an understudied mechanism that could amplify the effects of a growing class of community resource referral information technologies.
A Simple Effective SCF Method for Computing Optical Gaps in Organic Chromophores
Authors: Roy Raj , Ghosal Abhisek , Roy Amlan K. 
Published: July 2021

AbstractPhotoluminescence effects in organic chromophores are of significant importance and requires precise description of low lying excited states. In this communication, we put forward an alternative time‐independent DFT scheme for computing lowest single‐particle excitation energy, especially for singlet excited state. This adopts a recently developed “virial“‐theorem based model of singlet‐triplet splitting which requires a DFT calculation on closed shell ground state and a restricted open‐shell triplet excited state, followed by a simple
integral evaluation. This produces vertical excitation energies in small molecules, linear and non‐linear polycyclic aromatic hydrocarbon and organic dyes in comparable accuracy to the TDDFT. We also explore the functional dependency of present method with three different functionals (B3LYP, wB97X and CAM‐B3LYP) for polyenes and linear acenes. A systematic comparison with literature value illustrates the validity and usefulness of the present scheme in determining optical gap with fair computational cost.
Impurity profiling and stability‐indicating method development and validation for the estimation of assay and degradation impurities of midostaurin in softgel capsules using HPLC and LC–MS
Authors: Lakka Narasimha Swamy , Kuppan Chandrasekar , Ravinathan Poornima 
Published: July 2021

AbstractMidostaurin (MDS) is used for the treatment of acute myeloid leukemia, myelodysplastic syndrome, and advanced systemic mastocytosis. MDS softgel capsule samples were subjected to stress testing per International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use guidelines for impurity profiling study. MDS underwent extensive degradation under stress testing (acid, alkaline, oxidative, photolytic, thermolytic, and hydrolysis conditions) and formed four degradation products (DPs). MDS and its DPs were separated well from one another with good resolution using reserved‐phase HPLC using an Inertsil ODS‐3V column (250 × 4.6 mm, 5 μm) and a mobile phase of ammonium formate (40 mM) and acetonitrile. The stability‐indicating characteristic of the newly developed method was proven for the estimation of MDS assay, and its organic impurities were free from interference. The validated method exhibited excellent linearity, accuracy, precision, specificity, detection limit, and quantitation limit within 25 min run time. Stress testing, robustness, and solution stability were performed to ensure the continuous performance of the developed method. The peak fractions of DPs formed under stress testing were isolated and characterized using LC–MS, 1H and 13C NMR, IR, and UV–Vis. The structure of the major DPs was predicted as DP1 based on the spectral data. The proposed method is effectively used for MDS in bulk drug and finished formulations in the pharmaceutical industry.
Justifying environmental sustainability in small‐ and medium‐sized enterprises: An analysis of complementary assets in the printing industry
Authors: Reyes‐Rodríguez Juan Felipe , Ulhøi John Parm 
Published: July 2021

AbstractContrary to large enterprises, the environmental impact from small‐ and medium‐sized enterprises (SMEs) has not, to the same extent, attracted stakeholder attention and engagement. A similar lack of attention seems to have dominated management scholars who seem to have predominantly focused on the competitive implications of environmental sustainability of large enterprises. To fill up some of that gap, this study draws on the resource‐based view of the firm and the innovation‐value‐capturing‐framework to identify and characterise complementary assets utilised to materialise the competitive advantage of environmental management practices (EMP) in SMEs. Based on a multifirm case study among Danish SMEs in the printing and graphic industry, we demonstrate why and how SMEs' strategic involvement in EMP can be justified. This research complements existing insights in the field by exposing how SMEs operating under conditions of weak appropriability can justify investment in EMP thus highlighting their role in pursuing corporate sustainability.
Characterizing the relationships between tertiary and community cancer providers: Results from a survey of medical oncologists in Southern California
Authors: Salgia Nicholas J. , Chehrazi‐Raffle Alexander , Hsu JoAnn , Zengin Zeynep , Salgia Sabrina , Chawla Neal S. , Meza Luis , Malhotra Jasnoor , Dizman Nazli , Muddasani Ramya , Ruel Nora , Cianfrocca Mary , Gong Jun , Anand Sidharth , Chiu Victor , Yeh James , Pal Sumanta K. 
Published: July 2021

AbstractBackgroundTertiary cancer centers offer clinical expertise and multi‐modal approaches to treatment alongside the integration of research protocols. Nevertheless, most patients receive their cancer care at community practices. A better understanding of the relationships between tertiary and community practice environments may enhance collaborations and advance patient care.MethodsA 31‐item survey was distributed to community and tertiary oncologists in Southern California using REDCap. Survey questions assessed the following attributes: demographics and features of clinical practice, referral patterns, availability and knowledge of clinical trials and precision medicine, strategies for knowledge acquisition, and integration of community and tertiary practices.ResultsThe survey was distributed to 98 oncologists, 85 (87%) of whom completed it. In total, 52 (61%) respondents were community practitioners and 33 (38%) were tertiary oncologists. A majority (56%) of community oncologists defined themselves as general oncologists, whereas almost all (97%) tertiary oncologists reported a subspecialty. Clinical trial availability was the most common reason for patient referrals to tertiary centers (73%). The most frequent barrier to tertiary referral was financial considerations (59%). Clinical trials were offered by 97% of tertiary practitioners compared to 67% of community oncologists (p = 0.001). Most oncologists (82%) reported only a minimal‐to‐moderate understanding of clinical trials available at regional tertiary centers.ConclusionsCommunity oncologists refer patients to tertiary centers primarily with the intent of clinical trial enrollment; however, significant gaps exist in their knowledge of trial availability. Our results identify the need for enhanced communication and collaboration between community and tertiary providers to expand patients’ access to clinical trials.
Identification of the prognostic value of elevated ANGPTL4 expression in gallbladder cancer‐associated fibroblasts
Authors: Wang Fang‐Tao , Li Xin‐Ping , Pan Mu‐Su , Hassan Mohamed , Sun Wei , Fan Yue‐Zu 
Published: July 2021

AbstractBackgroundCancer‐associated fibroblasts (CAFs) with different gene profiles from normal fibroblasts (NFs) have been implicated in tumor progression. Angiopoietin‐like protein 4 (ANGPTL4) has been shown to regulate tumor angiogenesis and metastasis, and predict poor prognosis. However, the ANGPTL4 expression in CAFs, especially in gallbladder CAFs (GCAFs) and its relationship with patient prognosis is unclear.MethodsAffymetrix gene profile chip analysis in vitro was performed to detect the different gene expression profiles between GCAFs and NFs. RT‐qPCR, immunohistochemistry, and western blotting were performed to investigate the different expression levels of ANGPTL4 in GCAFs/NFs in vitro and in an in vivo nude mouse model of xenograft tumors. Finally, the ANGPTL4 expression was investigated in the stroma of different lesion tissues of the human gallbladder by immunohistochemistry, especially the expression in GCAFs in vivo by co‐immunofluorescence, and their prognostic significance in patients with gallbladder cancer (GBC) was assessed.ResultsANGPTL4 was upregulated in both GCAFs in vitro and in the xenograft stroma of nude mice in vivo, and its expression was also significantly upregulated in human GBC stroma co‐localized with the interstitial markers fibroblast secreted protein‐1 and α‐smooth muscle actin. In addition, the elevated ANGPTL4 expression in GCAFs was correlated with tumor differentiation, liver metastasis, venous invasion and Nevin staging, and GBC patients with an elevated ANGPTL4 expression in GACFs were found to have a lower survival rate.ConclusionsIncreased ANGPTL4 expression in GCAFs correlates with poor patient prognosis, which indicates a potential therapeutic target for human GBCs.
Expression and prognostic potential of PLEK2 in head and neck squamous cell carcinoma based on bioinformatics analysis
Authors: Wang Jingyun , Sun Zhuang , Wang Jing , Tian Qihai , Huang Runda , Wang Hanyu , Wang Xiaohui , Han Fei 
Published: July 2021

AbstractBackgroundPLEK2 (pleckstrin) could bind to membrane‐bound phosphatidylinositols and further promote cell spread. Recently, several studies have noted the importance of PLEK2 in tumor metastasis. However, the role of PLEK2 in head and neck squamous cell carcinoma (HNSCC) remains to be elucidated.MethodsThe PLEK2 expression in HNSCC was identified using Oncomine, Gene Expression Omnibus (GEO), UALCAN databases, and western blot analysis. Prognosis analysis was performed using Kaplan–Meier plotter, DriverDBv3, UALCAN, UCSC Xena, and GEO databases. Single‐cell functional analysis was further performed using the cancerSEA database. The PLEK2‐related co‑expressed genes were identified, and gene set enrichment analysis was performed using LinkedOmics. Furthermore, the top 10 hub genes were identified using the cytoHubba plug‐in of Cytoscape. Then, gene enrichment analysis, pathway activity, and drug sensitivity analyses of the hub genes were performed using the R package “clusterProfiler” and GSCAlite. Finally, the UCSC Xena browser was utilized to explore the hub gene most likely to play a synergic role with PLEK2 in HNSCC.ResultsElevated expression of PLEK2 was observed in HNSCC and even in HNSCC subgroups based on diverse clinicopathological features, portending a poor prognosis in HNSCC. PLEK2 was correlated with metastasis and hypoxia in HNSCC, and the PLEK2‐related co‐expressed genes were mainly involved in the focal adhesion pathway. The top 10 hub genes were primarily enriched in focal adhesion, HPV infection, ECM‐receptor interaction, and PI3K‐AKT signaling pathway, and epithelial–mesenchymal transition pathway was activated. Furthermore, the expression levels of the hub genes were associated with sensitivity and resistance to various small molecules and anti‐cancer drugs. Further study suggested that ITGA3 and PLEK2 might be viewed as inextricably linked in facilitating HNSCC metastasis.ConclusionsIn general, PLEK2 might serve as a potential biomarker for the diagnosis of HNSCC and guide the development of targeted therapies for HNSCC.
Treating eating disorders in groups: A pilot study on the role of a structured intervention on perfectionism on group climate
Authors: Margherita Giorgia , Gargiulo Anna , Gaudioso Rosita , Esposito Giovanna 
Published: July 2021

AbstractSeveral studies have shown the efficacy of group treatments for patients with eating disorders (EDs) who have negative attitudes towards their bodies, also using the group climate as an indicator of process. Within this field of study, perfectionism has been examined as a factor that maintains eating disorders. This study proposes to comprehend what kind of treatment favours a better group climate, by providing a within‐person comparison between two short group treatments of ED patients, where one was not focused on a specific topic and the other was structured around the topic of clinical perfectionism. Two groups of young adult patients with eating disorders were monitored for three months. Group climate was measured both with the Group Climate Questionnaire, which was administered at the end of each session, and through the clinical accounts written by an observer. The findings revealed that the perfectionism group, in comparison with the control group, presented a significantly higher level of engagement and avoidance, along with a lower level of conflict. In particular, the engagement of the perfectionism group increased in accordance with the therapeutic process, whilst in the control group, it remained relatively constant. The conflict decreased in both groups whilst avoidance increased alongside the sessions of the perfectionism group and decreased in the control group. The group on perfectionism, despite its enhanced high levels of avoidance, was effective in promoting a positive group climate. The clinical implications of structured group treatment for eating disorders, which manage the theme of mind‐body splitting, will be discussed.
Interventions for benzodiazepine withdrawal: Perceptions of benzodiazepine counsellors
Authors: Wurf Gerald , Swing Alice 
Published: July 2021

AbstractGovernments have been urged to adopt real‐time prescription monitoring in order to manage and reduce risks associated with the long‐term use of sleep and anti‐anxiety medications. Given this imperative, accessible psychological interventions for benzodiazepine (BZD) dependency and withdrawal are essential. The aim of this study was to understand how counsellors support clients assessed as suitable for community‐based drug withdrawal services to reduce their BZD use. Six BZD counsellors and two service coordinators were interviewed. Counsellors collaborated with their clients and prescribing doctors to develop individualised taper schedules that were in line with recommended clinical guidelines. Psychoeducation underscored a range of evidence‐based interventions, and a trauma‐informed approach was considered essential in working with clients to reduce their use of BZDs. Continuity in care was affected by the degree of prescribing doctor support for the taper. Counsellors reported that workforce sustainability was enhanced by quality clinical supervision and professional development opportunities. The role of counsellors in providing accessible, community‐based interventions for clients to reduce their use of BZDs was supported. Psychosocial support, combined with a medically supervised taper, has a strong evidence base and implications for client‐centred interventions are discussed.
Final 3‐year clinical outcomes following transcatheter aortic valve implantation with a supra‐annular self‐expanding repositionable valve in a real‐world setting: Results from the multicenter FORWARD study
Authors: Van Mieghem Nicolas M. , Windecker Stephan , Manoharan Ganesh , Bosmans Johan , Bleiziffer Sabine , Modine Thomas , Linke Axel , Scholtz Werner , Tchétché Didier , Finkelstein Ariel , Ito Saki , Eisenberg Ruth , Grube Eberhard 
Published: July 2021

AbstractObjectivesThe Evolut R FORWARD study confirmed safety and effectivenesss of the Evolut R THV in routine clinical practice out to 1 year. Herein, we report the final 3‐year clinical follow up of the FORWARD study.BackgroundTranscatheter aortic valve replacement (TAVR) is a proven alternative to surgery in elderly patients with symptomatic severe aortic stenosis. Long‐term clinical outcome data with the Evolut R platform are scarce.MethodsFORWARD is a prospective multicenter observational study that evaluated the Evolut R system in routine clinical practice at 53 centres. Eligible patients had symptomatic native aortic valve stenosis or failed surgical aortic bioprosthesis and elevated operative risk per Heart‐Team assessment. TAVR was attempted in 1039 patients.ResultsMean age was 81.8 ± 6.2 years, 64.9% were women, STS score was 5.5 ± 4.5% and 34.2% were frail. Rates of all‐cause mortality and disabling stroke were 24.8% and 4.8% at 3 years. Early need for a new pacemaker implantation after TAVR (all‐cause mortality: with new PPI; 21.0% vs. without; 22.8%, p = 0.55) and the presence of > trace paravalvular regurgitation (all‐cause mortality: no or trace; 22.0% vs. ≥ mild; 25.5%, p = 0.29) did not affect survival. Between 1 and 3 years incidence rates of valve related intervention, endocarditis and clinically relevant valve thrombosis were low.ConclusionsThe Evolut R valve maintained a favorable safety profile through 3 years in routine clinical practice. Rates of transcatheter heart valve‐related adverse events were low.
Ultrahigh Rate Capability and Lifespan MnCo2O4/Ni‐MOF Electrode for High Performance Battery‐Type Supercapacitor
Authors: Yang Fan , Guo Hao , Chen Yuan , Xu Mengni , Yang Wenhu , Wang Mingyue , Yang Meng , Zhang Junye , Sun Lei , Zhang Tingting , Yang Wu 
Published: July 2021

AbstractMnCo2O4 is derived from a Co/Mn bimetallic metal‐organic framework (MOF). Then Ni‐MOF is directly grown on the surface of the obtained MnCo2O4 to form a nano‐flower structure with small balls. A large surface area, abundant active sites of MnCo2O4 and porosity of Ni‐MOF allow the prepared MnCo2O4/Ni‐MOF composite material to deliver an excellent electrochemical performance. At the same time, an appropriate thermal treatment temperature of the MnCo2O4 precursor is also very important for controlling the morphology of the obtained MnCo2O4 and electrochemical performances of the resulted composite material including electric conductivity, specific capacitance and rate performance. The prepared MnCo2O4‐600/Ni‐MOF shows an ultrahigh rate performance (when the current density increases from 1 to 10 A g−1, the capacitance retention rate is as high as 93.41 %) and good cycle stability (the assembled asymmetric supercapacitor advice delivers a capacitance retention rate of 94.74 % after 20 000 charge and discharge cycles) as well as a relatively high specific capacitance. These excellent electrochemical properties indicate that MnCo2O4/Ni‐MOF has a good application prospect in the market.
Mathematical Modeling of Drying Processes of Selected Fruits and Vegetables
Authors: Reppich Marcus , Jegla Zdeněk , Grondinger Jakob , Azouma Yaovi Ouézou , Turek Vojtěch 
Published: July 2021

AbstractThis study investigates the behavior of fruit and vegetable samples during drying. The experimental data are fitted to several different thin‐layer drying models. Regression analysis is used to determine model parameters, while statistical indicators serve to evaluate the goodness of fit. The power function model gives the best fit for all examined samples. Based on this model, different drying and heat storage technologies can be combined to ensure that the required residual moisture content of an agricultural product is reached. It is demonstrated on the case of a specific Togolese processing plant that under favorable conditions, fossil fuel consumption can be decreased by 33 %.
Improved bilayer convolution transfer learning neural network for industrial fault detection
Authors: Wang Jing , Zhang Wenqian , Wu Haiyan , Zhou Jinglin 
Published: July 2021

AbstractMachine learning methods have achieved outstanding results in the fault detection of industrial processes when the training and test data follow the same distribution or originate from the same situation. However, the pre‐trained detection model fails when the operation status changes or unknown fault occurs during the actual production. Therefore, this paper proposes a novel bilayer convolutional transfer learning neural network (BCTLNN) to improve the generalization of detection model. BCTLNN is a bilayer network (local and global level) in order to extract the fault features. Transfer learning strategies (fine‐tuning and domain adaptation) are introduced to learn the domain invariant features by minimizing the divergence between different domain data. Experiments on the benchmark bearing data and the agglomeration fault data from an actual polyethylene process are employed to verify the effectiveness of the proposed method.
Myosin's powerstroke occurs prior to the release of phosphate from the active site
Authors: Scott Brent , Marang Christopher , Woodward Mike , Debold Edward P. 
Published: July 2021

AbstractMyosins are a family of motor proteins responsible for various forms of cellular motility, including muscle contraction and vesicular transport. The most fundamental aspect of myosin is its ability to transduce the chemical energy from the hydrolysis of ATP into mechanical work, in the form of force and/or motion. A key unanswered question of the transduction process is the timing of the force‐generating powerstroke relative to the release of phosphate (Pi) from the active site. We examined the ability of single‐headed myosin Va to generate a powerstroke in a single molecule laser trap assay while maintaining Pi in its active site, by either elevating Pi in solution or by introducing a mutation in myosin's active site (S217A) to slow Pi‐release from the active site. Upon binding to the actin filament, WT myosin generated a powerstoke rapidly (≥500 s−1) and without a detectable delay, both in the absence and presence of 30 mM Pi. The elevated levels of Pi did, however, affect event lifetime, eliminating the longest 25% of binding events, confirming that Pi rebound to myosin's active site and accelerated detachment. The S217A construct also generated a powerstroke similar in size and rate upon binding to actin despite the slower Pi release rate. These findings provide direct evidence that myosin Va generates a powerstroke with Pi still in its active site. Therefore, the findings are most consistent with a model in which the powerstroke occurs prior to the release of Pi from the active site.