bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D free-hand ultrasound to register anatomical landmarks at the pelvis and localize the hip joint center in lean and obese individuals
Authors: Horsak Brian , Schwab Caterine , Durstberger Sebastian , Thajer Alexandra , Greber-Platzer Susanne , Kainz Hans , Jonkers Ilse , Kranzl Andreas 
Published: May 2021

Abstract3D free-hand ultrasound (3DFUS) is becoming increasingly popular to assist clinical gait analysis because it is cost- and time-efficient and does not expose participants to radiation. The aim of this study was to evaluate its reliability in localizing the anterior superior iliac spine (ASIS) at the pelvis and the hip joint centers (HJC). Additionally, we evaluated its accuracy to get a rough estimation of the potential to use of 3DFUS to segment bony surface. This could offer potential to register medical images to motion capture data in future. To evaluate reliability, a test–retest study was conducted in 16 lean and 19 obese individuals. The locations of the ASIS were determined by manual marker placement (MMP), an instrumented pointer technique (IPT), and with 3DFUS. The HJC location was also determined with 3DFUS. To quantify reliability, intraclass correlation coefficients (ICCs), the standard error of measurement (SEm), among other statistical parameters, were calculated for the identified locations between the test and retest. To assess accuracy, the surface of a human plastic pelvic phantom was segmented with 3DFUS in a distilled water bath in 27 trials and compared to a 3D laser scan of the pelvis. Regarding reliability, the MMP, but especially the IPT showed high reliability in lean (SEm: 2–3 mm) and reduced reliability in obese individuals (SEm: 6–15 mm). Compared to MMP and IPT, 3DFUS presented lower reliability in the lean group (SEm: 2–4 mm vs. 2–8 mm, respectively) but slightly better values in the obese group (SEm: 7–11 mm vs. 6–16 mm, respectively). Correlations between test–retest reliability and torso body fat mass (% of body mass) indicated a moderate to strong relationship for MMP and IPT but only a weak correlation for the 3DFUS approach. The water-bath experiments indicated an acceptable level of 3.5 (1.7) mm of accuracy for 3DFUS in segmenting bone surface. Despite some difficulties with single trials, our data give further rise to the idea that 3DFUS could serve as a promising tool in future to inform marker placement and hip joint center location, especially in groups with higher amount of body fat.
Germination response to water availability in populations of Festuca pallescens along a Patagonian rainfall gradient based on hydrotime model parameters
Authors: López Aldana S. , López D. R. , Arana M. V. , Batlla D. , Marchelli P. 
Published: May 2021

AbstractSensitivity to water availability is a key physiological trait for grassland species located in arid and semiarid environments, where successful germination is closely related to rainfall dynamics. Festuca pallescens inhabits diverse environments along a steep precipitation gradient in North Patagonia, thus offering a suitable model for the study of germination behavior in response to water availability. By analyzing germination in nine populations using a hydrotime model approach, we aimed to find within-species variation. Seed population behavior was analyzed under different hydric conditions using hydrotime model parameters (hydrotime, mean base water potential and its standard deviation). We estimated the mean base water potential for F. pallescens (ψb(50) = − 2.79 ± 0.45 MPa), which did not differ significantly between populations. However, the hydrotime parameter (θH) varied markedly, suggesting physiological adaptation to local environments. Higher values of θH were found in populations located at the extremes of the distribution gradient, indicating that germination may be prevented or delayed in conditions that are suboptimal for the species. Since the variation in hydrotime model parameters did not follow a cline, micro-environmental cues may have the greatest influence on the physiological behavior of the species, rather than the macroscale rainfall gradient.
Impact of soil water regimes and partial root-zone drying in field-grown papaya in semi-arid conditions
Authors: Santos Dionei Lima , Coelho Eugênio Ferreira , de Oliveira Rubens Alves , Filgueiras Roberto , da Silva Alves Márcio , Rodrigues Weverton Pereira , Campostrini Eliemar , Sampaio Antônio Hélder Rodrigues , da Silva Reis João Batista Ribeiro , da Cunha Fernando França 
Published: May 2021

AbstractThis study aimed to evaluate in the papaya Tainung genotype, the effects of partial root-zone drying (PRD) technique on soil water regimes by using different frequencies of shifting irrigation-side of plant row and the effects of PRD technique on (1) crop agronomic performance, (2) titratable fruit acidity (TA), (3) total soluble solids (TSS), and TSS/TA ratio. Also, we analyze the spatial dynamic of papaya condition using normalized difference vegetation index (NDVI) from different satellite images. The study was conducted in the semi-arid region of Bahia (BA) and Minas Gerais (MG), Brazil. The combination of 100% (Full irrigation—FU), 50%, and 35% in the irrigation depth (WID) and frequencies of shifting plant-row side irrigation of 0 (Fixed Irrigation—FX), 7, 14, and 21 days were applied. Nine treatments were studied in BA and five in MG. The water available in the soil was reduced to 44% for frequencies of shifting plant-row side irrigation of 7 days, 50% for 14 days, and 85% for 21 days, compared to the soil water availability at field capacity. Partial water deficit in the soil through the PRD technique did not significantly reduce the total root length, effective root depth, and root effective horizontal distance of the papaya Tainung genotype. However, PRD treatments showed leaf abscission, which resulted in reduced leaf area and NDVI values, especially in the MG experiment. Papaya yield and fruit quality were not affected. However, except for PRD 21 35%, irrigation water depth reduced to 50 and 35% under PRD increased crop water productivity (CWP) in papaya plants. Thus, the PRD technique may save 35% of WID using the alternation of lateral shift irrigation of crop row every 7 days under water scarcity in semi-arid regions. The NDVI index was important to compare the papaya canopy vigor between the experimental areas studied. We also confirmed the potential of NDVI to monitor the vigor of papaya canopy, since we could notice the sensibility of NDVI to identify water stress in papaya in higher vapor pressure deficit (VPD) conditions occurred in October 2016 and January 2017 in Bom Jesus da Lapa-BA. Therefore, the PRD strategy can be a useful tool to save water in papaya cultivation under semi-arid conditions.
Contrasting metabolic strategies of two co-occurring deep-sea octocorals
Authors: Rakka M. , Maier S. R. , Van Oevelen D. , Godinho A. , Bilan M. , Orejas C. , Carreiro-Silva M. 
Published: May 2021

AbstractThe feeding biology of deep-sea octocorals remains poorly understood, as attention is more often directed to reef building corals. The present study focused on two common deep-water octocoral species in the Azores Archipelago, Dentomuricea aff. meteor and Viminella flagellum, aiming at determining their ability to exploit different food sources. We adopted an experimental approach, with three different food sources, including live phytoplankton, live zooplankton and dissolved organic matter (DOM), that were artificially enriched with 13C and 15N (C and N tracers). The presence of tracers was subsequently followed in the coral tissue, C respiration and particulate organic C and N (POC and PON) release. In both species, feeding with zooplankton resulted in significantly higher incorporation of tracers in all measured variables, compared to the other food sources, highlighting the importance of zooplankton for major physiological processes. Our results revealed contrasting metabolic strategies between the two species, with D. aff. meteor acquiring higher amounts of prey and allocating higher percentage to respiration and release of POC and PON than V. flagellum. Such metabolic differences can shape species fitness and distributions and have further ecological implications on the ecosystem function of communities formed by different octocoral species.
Extracts from Pulsatilla patens target cancer-related signaling pathways in HeLa cells
Authors: Łaska Grażyna , Maciejewska-Turska Magdalena , Sieniawska Elwira , Świątek Łukasz , Pasco David S. , Balachandran Premalatha 
Published: May 2021

AbstractThe purpose of this study was to determine if a methanolic extract of the Pulsatilla patens (L.) Mill. can inhibit the progression of cancer through the modulation of cancer-related metabolic signaling pathways. We analyzed a panel of 13 inducible luciferase reporter gene vectors which expression is driven by enhancer elements that bind to specific transcription factors for the evaluation of the activity of cancer signaling pathways. The root extract of P. patens exhibited strong inhibition of several signaling pathways in HeLa cells, a cervical cancer cell line, and was found to be the most potent in inhibiting the activation of Stat3, Smad, AP-1, NF-κB, MYC, Ets, Wnt and Hdghog, at a concentration of 40 µg/mL. The methanolic extracts of P. patens enhanced apoptotic death, deregulated cellular proliferation, differentiation, and progression towards the neoplastic phenotype by altering key signaling molecules required for cell cycle progression. This is the first study to report the influence of Pulsatilla species on cancer signaling pathways. Further, our detailed phytochemical analysis of the methanolic extracts of the P. patens allowed to deduce that compounds, which strongly suppressed the growth and proliferation of HeLa cancer cells were mainly triterpenoid saponins accompanied by phenolic acids.
Primary sclerosing cholangitis and the risk of cancer, cardiovascular disease, and all-cause mortality: a systematic review and meta-analysis of cohort studies
Authors: Aune Dagfinn , Sen Abhijit , Norat Teresa , Riboli Elio , Folseraas Trine 
Published: May 2021

AbstractA diagnosis of primary sclerosing cholangitis (PSC) has been associated with increased risk of hepatobiliary cancers, colorectal cancer and all-cause mortality in several studies, while associations with cardiovascular disease have been inconsistent. We conducted a systematic review and meta-analysis of published cohort studies on the topic to summarize these associations. PubMed and Embase databases were searched up to January 13th, 2020. Cohort studies on PSC and risk of cancer, cardiovascular disease, or mortality were included. Summary relative risks (RRs) and 95% confidence intervals (95% CIs) were estimated using random effects models. The summary RR (95% CI) comparing persons with PSC to persons without PSC was 584.37 (269.42–1267.51, I2 = 89%, n = 4) for cholangiocarcinoma (CCA), 155.54 (125.34–193.02, I2 = 0%, n = 3) for hepatobiliary cancer, 30.22 (11.99–76.17, I2 = 0%, n = 2) for liver cancer, 16.92 (8.73–32.78, I2 = 88%, n = 4) for gastrointestinal cancer, 7.56 (2.42–23.62, I2 = 0%, n = 3) for pancreatic cancer, 6.10 (4.19–8.87, I2 = 14%, n = 7) for colorectal cancer (CRC), 4.13 (2.99–5.71, I2 = 80%, n = 5) for total cancer, 3.55 (2.94–4.28, I2 = 46%, n = 5) for all-cause mortality, and 1.57 (0.25–9.69, I2 = 79%, n = 2) for cardiovascular disease. Strong positive associations were observed between PSC and risk of CCA, hepatobiliary cancer, liver cancer, gastrointestinal cancer, pancreatic cancer, CRC, total cancer, and all-cause mortality, but not for cardiovascular disease.
Prognostic value of low skeletal muscle mass in patient treated by exclusive curative radiochemotherapy for a NSCLC
Authors: Mallet R. , Decazes P. , Modzelewski R. , Lequesne J. , Vera P. , Dubray B. , Thureau S. 
Published: May 2021

AbstractLow skeletal muscle mass is a well-known prognostic factor for patients treated for a non-small-cell lung cancer by surgery or chemotherapy. However, its impact in patients treated by exclusive radiochemotherapy has never been explored. Our study tries to evaluate the prognostic value of low skeletal muscle mass and other antropometric parameters on this population. Clinical, nutritional and anthropometric date were collected for 93 patients treated by radiochemotherapy for a NSCLC. Anthropometric parameters were measured on the PET/CT by two methods. The first method was a manual segmentation at level L3, used to define Muscle Body Area (MBAL3), Visceral Fat Area (VFAL3) and Subcutaneous Fat Area (SCFAL3). The second method was an software (Anthropometer3D), allowing an automatic multislice measurement of Lean Body Mass (LBMAnthro3D), Fat Body Mass (FBMAnthro3D), Muscle Body Mass (MBMAnthro3D), Visceral Fat Mass (VFMAnthro3D), and Sub-Cutaneous Fat Mass (SCFMAnthro3D) on the PET/CT. All anthropometrics parameters were normalised by the patient's height. The primary end point was overall survival time. Univariate and then stepwise multivariate cox analysis were performed for significant parameters. Finally, Spearman's correlation between MBAL3 and MBMAnthro3D was assessed. Forty-one (44%) patients had low skeletal muscle mass. The median overall survival was 18 months for low skeletal muscle mass patients versus 36 months for non-low skeletal muscle mass patients (p = 0.019). Low skeletal muscle mass (HR = 1.806, IC95% [1.09–2.98]), serums albumin level < 35 g/l (HR = 2.203 [1.19–4.09]), Buzby Index < 97.5 (HR = 2.31 [1.23–4.33]), WHO score = 0 (HR = 0.59 [0.31–0.86] and MBMAnthro3D < 8.56 kg/m2 (HR = 2.36 [1.41–3.90]) were the only significant features in univariates analysis. In the stepwise multivariate Cox analysis, only MBMAnthro3D < 8.56 kg/m2 (HR = 2.16, p = 0.003) and WHO score = 0 (HR = 0.59, p = 0.04) were significant. Finally, muscle quantified by MBAL3 and MBMAnthro3D were found to be highly correlated (Spearman = 0.9). Low skeletal muscle mass, assessed on the pre-treatment PET/CT is a powerful prognostic factor in patient treated by radiochemotherapy for a NSCLC. The automatic software Anthropometer3D can easily identify patients a risk that could benefit an adapted therapy.
RETRACTED ARTICLE: Impact of daily high dose oral vitamin D therapy on the inflammatory markers in patients with COVID 19 disease
Authors: Lakkireddy Maheshwar , Gadiga Srikanth Goud , Malathi R. D. , Karra Madhu Latha , Raju I. S. S. V. Prasad Murthy , Ragini  , Chinapaka Sangeetha , Baba K. S. S. Sai , Kandakatla Manohar 
Published: May 2021

AbstractCOVID 19 is known to cause immune dysregulation and vitamin D is a known immunomodulator. This study aims to objectively investigate the impact of Pulse D therapy in reducing the inflammatory markers of COVID-19. Consented COVID-19 patients with hypovitaminosis D were evaluated for inflammatory markers (N/L ratio, CRP, LDH, IL6, Ferritin) along with vitamin D on 0th day and 9th/11th day as per their respective BMI category. Subjects were randomised into VD and NVD groups. VD group received Pulse D therapy (targeted daily supplementation of 60,000 IUs of vitamin D for 8 or 10 days depending upon their BMI) in addition to the standard treatment. NVD group received standard treatment alone. Differences in the variables between the two groups were analysed for statistical significance. Eighty seven out of one hundred and thirty subjects have completed the study (VD:44, NVD:43). Vitamin D level has increased from 16 ± 6 ng/ml to 89 ± 32 ng/ml after Pulse D therapy in VD group and highly significant (p < 0.01) reduction of all the measured inflammatory markers was noted. Reduction of markers in NVD group was insignificant (p > 0.05). The difference in the reduction of markers between the groups (NVD vs VD) was highly significant (p < 0.01). Therapeutic improvement in vitamin D to 80–100 ng/ml has significantly reduced the inflammatory markers associated with COVID-19 without any side effects. Hence, adjunctive Pulse D therapy can be added safely to the existing treatment protocols of COVID-19 for improved outcomes.
Inhibitory synaptic transmission is impaired at higher extracellular Ca2+ concentrations in Scn1a+/− mouse model of Dravet syndrome
Authors: Uchino Kouya , Kawano Hiroyuki , Tanaka Yasuyoshi , Adaniya Yuna , Asahara Ai , Deshimaru Masanobu , Kubota Kaori , Watanabe Takuya , Katsurabayashi Shutaro , Iwasaki Katsunori , Hirose Shinichi 
Published: May 2021

AbstractDravet syndrome (DS) is an intractable form of childhood epilepsy that occurs in infancy. More than 80% of all patients have a heterozygous abnormality in the SCN1A gene, which encodes a subunit of Na+ channels in the brain. However, the detailed pathogenesis of DS remains unclear. This study investigated the synaptic pathogenesis of this disease in terms of excitatory/inhibitory balance using a mouse model of DS. We show that excitatory postsynaptic currents were similar between Scn1a knock-in neurons (Scn1a+/− neurons) and wild-type neurons, but inhibitory postsynaptic currents were significantly lower in Scn1a+/− neurons. Moreover, both the vesicular release probability and the number of inhibitory synapses were significantly lower in Scn1a+/− neurons compared with wild-type neurons. There was no proportional increase in inhibitory postsynaptic current amplitude in response to increased extracellular Ca2+ concentrations. Our study revealed that the number of inhibitory synapses is significantly reduced in Scn1a+/− neurons, while the sensitivity of inhibitory synapses to extracellular Ca2+ concentrations is markedly increased. These data suggest that Ca2+ tethering in inhibitory nerve terminals may be disturbed following the synaptic burst, likely leading to epileptic symptoms.
Wnt signaling in lung development, regeneration, and disease progression
Authors: Aros Cody J. , Pantoja Carla J. , Gomperts Brigitte N. 
Published: May 2021

AbstractThe respiratory tract is a vital, intricate system for several important biological processes including mucociliary clearance, airway conductance, and gas exchange. The Wnt signaling pathway plays several crucial and indispensable roles across lung biology in multiple contexts. This review highlights the progress made in characterizing the role of Wnt signaling across several disciplines in lung biology, including development, homeostasis, regeneration following injury, in vitro directed differentiation efforts, and disease progression. We further note uncharted directions in the field that may illuminate important biology. The discoveries made collectively advance our understanding of Wnt signaling in lung biology and have the potential to inform therapeutic advancements for lung diseases.
Notch–Rho–cGMP interaction: common point of convergence in microvascular aging-related disease
Authors: Roks Anton J.M. , Cheng Caroline , Shanahan Catherine M. 
Published: May 2021

Abstract
Vascular smooth muscle biology is increasingly exploited as an interventional target in vascular disease. Vascular smooth muscle Notch3–Rho kinase–cGMP interaction has been implicated in brain and peripheral arteriopathy in CADASIL. In the present commentary, we discuss the potential implications for other, more common non-atherosclerotic microvascular diseases: INOCA and HFpEF. The relation to mechanotransduction, to cellular senescence and to sGC activators as potential intervention agents are described.
Comprehensive platform for distribution transactive energy markets
Authors: Sabillon Carlos , Mohamed Amr A. , Golriz Ali , Venkatesh Bala 
Published: May 2021

AbstractReducing the cost of distributed energy resources (DERs) such as renewables, storage, electric vehicles and smart loads is driving their increased connection to distribution systems. Extracting maximum benefits from DERs require liberalising distribution systems by allowing: (1) a distribution transactive energy market (DTEM) operated by a local distribution operator (LDO) and (2) peer‐to‐peer (P2P), peer‐to‐LDO (P2LDO) and Transmission‐to‐LDO (T2LDO) type transactions. A DTEM will bring several benefits such as: (1) enhanced economic opportunity for DERs, making them more profitable and (2) increased social welfare benefiting both buyers and sellers. To achieve this objective, we develop a comprehensive three‐phase DTEM platform that provides maximum economic opportunities for DERs and maximises social welfare that benefits all market participants, while considering P2P, P2LDO and T2LDO transactions, for both energy and ancillary services. Interaction between bulk electricity market independent system operator (ISO) and LDO controlled DTEM is presented. The DTEM model is implemented as a practical mixed‐integer linear programming formulation that includes a network reconfiguration feature. The DTEM model is studied on three‐phase 5‐bus and 34‐bus systems, demonstrating its effectiveness to settle energy and ancillary service transactions, while obtaining distribution locational marginal prices. Results show that P2P transactions, when allowed, increase social welfare and increases profitability of DERs.
Optimal short‐circuit current control of the grid‐forming converter during grid fault condition
Authors: Liu Chang , Cai Xu , Li Rui , Yang Renxin 
Published: May 2021

AbstractA considerable amount of rotating synchronous machines are being replaced by the increasing capacity of converter‐based resources, which has stimulated a demand for grid‐forming converters (GFCs) for grid supporting. The inertia and frequency responses of GFC are remarkably similar to those of synchronous generator (SG), but the inadequate capability of sourcing short‐circuit current of GFCs during grid fault can lead to several serious consequences. The low short‐circuit current level fails to trigger protection relays and cannot provide sustained voltage support during the fault or more effectively support the recovery of voltage after fault clearance. The short‐term overcurrent capability of GFC can be promoted either from the point of view of the power devices or from the topology of it. The overcurrent capability of converter is hard‐earned, so full use of it should be made. This paper proposes an optimal control strategy of short‐circuit current of GFC, which can enable the GFC to source the short‐circuit current with an optimal angle within the allowable magnitude. A detailed simulation model of the proposed method here is set up in PSCAD/EMTDC. The simulation results show that the proposed method can achieve better voltage supporting results compared with the traditional reactive support control.
A survey on blockchain‐enabled smart grids: Advances, applications and challenges
Authors: Liu Chao , Zhang Xiaoshuai , Chai Kok Koeng , Loo Jonathan , Chen Yue 
Published: May 2021

AbstractElectric power grid infrastructure has revolutionized our world and changed the way of living. So has blockchain technology. The hierarchical electric power grid has been shifting from a centralized structure to a decentralized structure to achieve higher flexibility and stability, and blockchain technology has been widely adopted in the energy sector to deal with grid management, billing, metering, and so on, because of its nature of decentralization. Here, the aim is to provide a multi‐dimensional review on the technological advances of the blockchain in smart grids. Its corresponding applications based on these advances, including company projects and use cases, are summarized. Furthermore, the security threat issues in smart grids, Ethereum Virtual Machine (i.e. the operating environment of consensus mechanisms), and smart contracts are analysed, with a brief conclusion to manifest the prior tasks in building secure blockchain‐based infrastructures in smart grids. As such, the challenges and features of different protocols and their applicability in each use case are identified to provide an insightful guide for future research studies.