bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eye Movements and Cognitive Functioning in Patients With Schizophrenia Spectrum Disorders: Network Analysis
Authors: Shmukler Alexander , Latanov Alexander V. , Karyakina Maria , Anisimov Victor N. , Churikova Marina A. , Sukhachevsky Ivan S. , Spektor Valery A. 
Published: November 2021

Background: Eye movement parameters are often used during cognitive functioning assessments of patients with psychotic spectrum disorders. It is interesting to compare these oculomotor parameters with cognitive functions, as assessed using psychometric cognitive tests. A network analysis is preferable for understanding complex systems; therefore, the aim of this study was to determine the multidimensional relationships that exist between oculomotor reactions and neurocognition in patients with schizophrenia spectrum disorders.Materials and Methods: A total of 134 subjects (93 inpatients with schizophrenia spectrum disorders (ICD-10) and 41 healthy volunteers) participated in this study. Psychiatric symptom severity was assessed using the Positive and Negative Syndrome Scale, the Calgary Depression Scale for Schizophrenia, and the Young Mania Rating Scale. Extrapyramidal symptoms were assessed using the Simpson-Angus Scale, and akathisia was assessed using the Barnes Akathisia Rating Scale. Eye movements were recorded using an eye-tracker SMI RED 500, and cognitive function was assessed using the Brief Assessment of Cognition in Schizophrenia. The statistical analyses were conducted using Minitab 17 Statistical Software, version 17.2.1. Data visualization and additional analyses were performed in the R 4.0.3 environment, using RStudio V 1.3.1093 software.Results: A network model of neurocognitive and oculomotor functions was constructed for the patients. In the full network (which includes all correlations) the median antisaccade latency value is the central element of the oculomotor domain, and the Symbol Coding test, the Digit Sequencing test, and the Verbal Fluency test are central elements in the neurocognitive domain. Additionally, there were connections between other cognitive and oculomotor functions, except for the antisaccade error latency in the oculomotor domain and the Token Motor Task in the neurocognitive domain.Conclusion: Network analysis provides measurable criteria for the assessment of neurophysiological and neurocognitive abnormalities in patients with schizophrenic spectrum disorders and allows to select key targets for their management and cognitive remediation.
Assessment of the Influence of Selected Procurement Practices on the Performance of Devolved Government Units in Kenya: A Case of Machakos County Government
Authors: Mutuku Diana Mutete , Agusioma Nickson Lumwagi , Wambua Julius 
Published: November 2021

In the devolved units in Kenya, despite the formulation of strategic plans, majority of the counties remain underdeveloped with the employees remaining reluctant thus citizens’ demand for better services remain un met. The devolved systems of governments in Kenya have also been experiencing major challenges in the execution of procurement practices. Counties continue to be criticized for corruption cases, stalled projects, under-development and massive wastage of public resources. All these aspects have been strongly linked to weak procurement management practices which raises concern. The purpose of the study was to determine the influence of contract management practices and procurement policies practices, on performance of Machakos County government. The methodology was descriptive research design that guided the study. The study was carried out in County government offices. The target population and unit of observations was 77 employees in procurement department in Machakos County comprising of senior managers and procurement employees, head of other departments as well budget committee members who were selected using a purposeful sampling approach. Data for the study was collected using questionnaires which were self-administered. The collected data was analyzed using descriptive and inferential analysis using SPSS version 24. Tables and figures were used in presenting the data. The study found out that Contract Monitoring and, Procurement policies had a positive influence on the performance of Machakos County. The study also concluded that for Machakos County to perform, the procurement department must be able to properly implement, monitor and evaluate these practices. The study recommends that the management of the county to improve on the level of compliance with procurement regulations compliance.
Impacto de los inhibidores de la bomba de protones en los niveles de vitamina B12 en pacientes con erc estadio 5 en hemodiálisis
Authors: Restrepo Duque Carlos Hernan , Botello Jaimes Jhon Jairo , Lopez Castro Lina Maria , Aguirre Arango Jose Vicente , Restrepo Cesar Augusto 
Published: November 2021

Objetivo: Establecer si en pacientes con enfermedad renal crónica (ERC) estadio 5 en terapia de hemodiálisis y uso crónico de inhibidores de bomba de protones (IBPs) se presenta deficiencia de VITAMINA B 12.
Métodos: Pacientes con ERC estadio 5 mayores de 18 años, en terapia de hemodiálisis crónica, quienes se encontraban recibiendo terapia con IBPs. En ellos se evaluaron variables demográficas, antropométricas y clinicas, tambien etiología de la enfermedad renal crónica, tiempo en diálisis, tipo de IBP que el paciente estaba recibiendo, dosis y tiempo que llevaban usando el medicamento. Las variables de laboratorio relacionadas fueron concentraciones séricas de vitamina B12, ácido fólico, KTV, hemoglobina y volumen corpuscular medio
Tipo de estudio: Analítico de corte transversal. Para el análisis estadístico se utilizaron medidas de tendencia central y de dispersión (media, desviación estándar) en las variables cuantitativas y frecuencias relativas en las cualitativas. Para determinar la correlación entre los niveles de vitamina B12 y las variables se utilizo el método de regresión lineal simple para cada una de las variables continuas y el de regresión logística para las categóricas
Resultados: 37 pacientes cumplieron con los criterios de inclusion, 45,9% mujeres, edad promedio 63,6 años, etiología de la ERC 48,6 % idiopática. Tiempo en diálisis 56,7% de las personas menos de 4 años, el resto entre 4 y 19 años. Consumo de IBPs 15 pacientes (40,5%) menos ó igual a 3 años y 22 pacientes (59,5%) mas de 3 años. 100 % de los pacientes exhibían cifras normales ó por encima de lo normal de niveles séricos de acido fólico. Se encontró correlación positiva (aunque no estadísticamente significativa) entre los niveles séricos de vitamina B12 y la dosis de IBPs, tiempo de consumo de IBPs y tiempo en diálisis.
Conclusiones: Contrariamente a lo planteado en la hipótesis de trabajo los valores séricos de vitamina B12, tienden a aumentar a medida que aumenta el tiempo en diálisis y el consumo de IBPs, tanto en tiempo, como en dosis
Nuevo Dispositivo de Micronebulización con Control Continuo de la Fracción Inspirada de Oxígeno ("CONTROLizer")
Authors: Orozco-Levi Mauricio , Ramírez-Sarmiento Alba , Espitia Angela , Saavedra Maria Fernanda , Mogollón Melissa , Cáceres Diana Isabel , Serrano Norma , Rodriguez Leonardo , Sarmiento Eugenio , Pizarro Camilo , Gea Joaquim 
Published: November 2021

Una de las técnicas más comunes de tratamiento respiratorio es la nebulización de medicamentos para administrarlos por vía inhalada utilizando oxígeno como propelente, el cual a su vez es considerado un fármaco que puede generar efectos adversos relacionados con la dosificación. El objetivo de esta investigación fue diseñar, desarrollar y analizar un sistema dual de micronebulización con control preciso de la FIO2.
Métodos: Se diseñó, construyó y evaluó un modelo virtual y un prototipo funcional siguiendo la metodología de bioingeniería de un nuevo dispositivo de micronebulización con control de FIO2. Se evaluó el funcionamiento del dispositivo y su impacto en voluntarios sanos y pacientes hospitalizados mediante escalas psicométricas específicas.
Resultados: Se conceptualizó, diseñó y construyó un dispositivo que integra un micronebulizador (cazoleta), que permite nebulizar suero fisiológico o soluciones de diversos fármacos basado en la presurización de un gas propelente (aire u oxígeno) junto a un mecanismo de ajuste de la fracción inspirada de O2 (mínimo, 21%; máximo de 99%). Los límites (máximo y mínimo) de flujo recomendado para generar el aerosol son 6-8 l/min. En ningún caso de uso se presentaron complicaciones.
Conclusiones: CONTROLizer es un dispositivo integrado dual y no-invasivo para la micronebulización de soluciones respiratorias y control continuo de la fracción inspirada de oxígeno. Por sus cualidades y funcionamiento, el dispositivo fue percibido como adecuado y seguro para aplicarse en individuos sanos y pacientes ingresados tanto en salas de cuidados intensivos como de hospitalización convencional.
Comorbidities and risk factors for COVID-19 in a group of Iraqi patients confirmed by real-time PCR test
Authors: Abbas Z , Manhal F 
Published: November 2021

The aim of the study was to identify characteristic risk factors predisposing to coronavirus disease 2019 (COVID-19) outbreak in a group of Iraqi patients in Baghdad City. In this study, we included a total of 13411 persons who had been tested for COVID-19, supervised by Al-Razi Medical Center in Baghdad City during the period from June 20 to November 13, 2020. Cases were tested and divided into two groups according to the result of real-time RT-PCR test for COVID-19. A total of 1781 positive cases were detected with confirmed COVID-19. Comorbidities in the study patients were identified as hypertension, diabetes mellitus and respiratory disorders. Hypertension was the most common comorbidity in COVID-19 patients followed by diabetes mellitus. The results of this study showed that patients with comorbidities were significantly associated with positive RT-PCR results related to COVID-19. It was concluded that understanding the comorbidities enhance defining patients with COVID-19 at higher risk. Further research is needed to confirm and clarify the impact of the association of co-morbidities that accompany COVID-19.
Saúde sexual e infecções sexualmente transmissí­veis na adolescência: Uma revisão integrativa
Authors: De Sousa Alves Letí­cia , Saraiva Aguiar Ricardo 
Published: November 2021

Objetivo: avaliar o conhecimento e o comportamento sexual dos adolescentes acerca das infecções sexualmente transmissí­veis. Método: trata-se de uma revisão integrativa da literatura realizada nas bases de dados SCIELO, LILACS e BDENF por meio da estratégia PICO para definição da pergunta norteadora e do fluxograma PRISMA para seleção dos artigos. As buscas abrangeram o perí­odo de 2014 a 2019, sendo selecionados os artigos disponí­veis em português, na í­ntegra e no formato original. Resultados: foram selecionados 10 artigos para a composição do estudo que demostraram déficit no conhecimento dos adolescentes acerca das infecções sexualmente transmissí­veis, bem como não utilização do preservativo de modo rotineiro devido acreditarem que este inibe o prazer sexual. Conclusão: necessita-se orientar os adolescentes acerca das circunstâncias que acarretam í s infecções sexualmente transmissí­veis e sobre o uso correto do preservativo por meio de intervenções e educação em saúde nas escolas e nos serviços de saúde.
PENGARUH SUNGKUP DAN JENIS MEDIA TANAM TERHADAP PERTUMBUHAN BIBIT ANGGREK Dendrobium SAAT AKLIMATISASI
Authors: Sudartini Tini , Zumani Darul , Diantini Della 
Published: November 2021

Salah satu upaya untuk meningkatkan pertumbuhan seedling anggrek invitro dalam fase aklimatisasi adalah penggunaan sungkup dan media tanam yang sesuai. Penelitian ini bertujuan: mempelajari pengaruh interaksi antara sungkup dan jenis media tanam terhadap pertumbuhan anggrek Dendrobium selama aklimatisasi Metode penelitian yang digunakan adalah metode penelitian eksperimental dengan menggunakan Rancangan Petak Terbagi. Perlakuan sungkup merupakan faktor utama yang terdiri dari 2 taraf yaitu tanpa menggunakan sungkup dan memakai sungkup serta perlakuan jenis media tanam merupakan anak petak yang terdiri dari 5 taraf yaitu pakis cacah, sabut kelapa, arang sekam, kulit pohon akasia, limbah sabut batang aren. Percobaan diulang 3 kali. Hasil penelitian menunjukkan bahwa terdapat pengaruh keterkaitan antara pemakaian sungkup dan jenis media tanam terhadap pertumbuhan anggrek selama aklimatisasi. Pemakaian sungkup dan jenis media arang sekam menghasilkan pertumbuhan bibit anggrek yang terbaik selama aklimatisasi.
EFFECT OF LEIOMYOMA ON MATERNAL AND FETAL OUTCOMES DURING PREGNANCY
Authors: OLUKLU Deniz , AKAR Serra , ÇAĞLAR Ali 
Published: November 2021

Aim: The study aimed to determine the effects of leiomyoma size, number, location, and type on obstetric and fetal outcomes, retrospectively.
Materials and Method: A total of 292 singleton pregnancies, who were attended to perinatology unit of Zekai Tahir Burak Women’s Health Training and Research Hospital in Ankara as part of routine antenatal follow-up between January 2007 and 2014 and delivered at or beyond 24 weeks were included. The study group consisted of patients with leiomyoma of 4 cm or more. Patients who underwent myomectomy during cesarean delivery, who had co-morbidities, uterine anomalies, or fetal malformations were excluded from the study. Obstetric and fetal outcomes were recorded.
Results: Vaginal delivery rate was significantly higher in patients with a single leiomyoma when compared to patients with 2 or more leiomyoma (p=0.009). Diagnosis of preterm labor was significantly higher in patients with leiomyoma size larger than 10 cm when compared to patients with leiomyoma sizes 4-7 cm and 7-10 cm (p =0.005 and p=0.002, respectively). The presentation anomaly rate was significantly higher in patients with leiomyoma sizes bigger than 10 cm when compared to patients with leiomyoma sizes 4-7 cm (p=0.008) and 7-10 cm (p =0.045). The need for transfusion was lower in the group with leiomyoma measuring 4-7 cm when compared to leiomyoma measuring 7-10 cm and those larger than 10 cm (p=0.010 and p = 0.011, respectively). Cesarean delivery rate was higher in patients with leiomyoma localized to the cervix and corpus in comparison to those localized to the corpus only (p =0.008). Vaginal delivery rate (40.9%) was higher in patients with intramural leiomyoma when compared to subserous (p=0.002) and combined (p=0.004) leiomyoma.
Conclusion: The prevalence of leiomyoma during pregnancy is increasing due to women planning pregnancy later in life, the increasing incidence of fibroids with age, and the rise of cesarean delivery rates which enables us to diagnose more cases in recent years. Patients with leiomyoma should be placed on close surveillance for possible complications during pregnancy, delivery and postpartum.
EVALUATION OF MATERNAL AND FETAL OUTCOMES OF PREGNANT WOMEN WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Authors: TURGUT Ezgi , TURAN Gökçe , KOOHNAVARD Soheil , KÜÇÜK Hamit , TUFAN Abdurrahman , KARÇAALTINCABA Deniz 
Published: November 2021

Aim: To evaluate obstetrical and perinatal outcomes of pregnancies with systemic lupus erythematosus (SLE).
Materials and Method: This was a retrospective study evaluating obstetric outcomes of 35 patients with SLE who were followed up between 2010 and 2020. Lupus activity was based on SLE Disease Activity Index (SLEDAI) criteria and pregnancy outcomes were evaluated by grouping as active and inactive SLE.
Results: The mean maternal age was 29 (21-39). The rate of antiphospholipid syndrome and active disease was 5% and 40% respectively. There were 30 live births. Two elective abortions were reported, one with major cardiac anomaly and the other with renal agenesis. One spontaneous abortion and 2 stillbirths were observed in the active SLE group. Overall rates of intrauterine growth retardation, preeclampsia, and preterm delivery were 8%, 20%, and 26%, respectively. Fetal loss and preterm delivery were significantly higher in the active SLE group (p=0,018, p=0,023). A higher rate of neonatal intensive care unit (NICU) admission was observed in the active SLE group (p=0,034) but Apgar scores less than 0,05).
Conclusion: Despite advances in the medical sciences, an active disease with SLE has an elevated risk of inducing adverse pregnancy outcomes. Close follow-up could helps reduce pregnancy complications, especially preterm deliveries.
Preeklampsi ve HELLP Sendromlu Olgularda Nötrofil-Lenfosit Oranı (NLO), Platelet-Lenfosit Oranı (PLO) ve Ortalama Platelet Hacminin (OPH) Karşılaştırılması
Authors: TAŞIN Cuma , AKCAN Serhat 
Published: November 2021

Amaç: Bu çalışmada hem HELLP sendromlu hem de preeklampsili hastaların NLO ve PLO değerleri normal sağlıklı kontrol grubu ile karşılaştırıldı.
Metod: Bu çalışma, 2012-2020 yılları arasında Mersin Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum servisine yatan 50 HELLP sendromu, 110 şiddetli Preeklampsi (PE) ve 61 kontrol hastasının dosyaları taranarak retrospektif olarak yapıldı. Çalışmada HELLP sendromu ve preeklampsi hastaları, sağlıklı kontrol grubu ile karşılaştırıldı. Ek hastalığı olan hastalar çalışma dışı bırakıldı. Hasta gruplarının venöz kan hemogram parametreleri ve doğum sırasında alınan biyokimyasal değerleri kaydedildi. Hastaların yaşı, gebelik haftası, karaciğer fonksiyon testleri, böbrek fonksiyon testleri, hemogram parametreleri, NLO ve PLO değerleri ve oluşan komplikasyonlar karşılaştırıldı. Çalışmanın etik onamı alındı (Karar tarihi:28/04/2021; Karar sayısı: 343)
Sonuçlar: Çalışmada nötrofil sayısı, HELLP sendromu grubunda, kontrol grubuna göre anlamlı olarak yüksek bulundu (sırası ile 9493 ve 7210 p=0,04). NLO, hem HELLP sendromu hem de PE grubunda, kontrol grubuna göre yüksek bulundu (HELLP sendromu grubunda kontrol grubuna göre anlamlı olarak yüksekti (sırası ile 5,47 ve 3,66, p=0,02)). PLO, hem HELLP sendromu hem de PE grubunda, kontrol grubuna göre düşük bulundu (HELLP sendromu grubunda, kontrol grubuna (sıra ile 72 ve 111,18, p=0,0001) ve PE grubuna göre (sırası ile 72 ve 107,75 p=0,0002) anlamlı olarak düşük bulundu). Platelet sayısında tüm gruplar arasında anlamlı fark vardı (HELLP sendromu grubunda, PE grubuna (sıra ile 139,181 ve 196,222, p=0,0002) ve kontrol grubuna (sıra ile 139,181 ve 222,639, p=0,0001) göre anlamlı olarak düşük bulundu. Ayrıca PE grubunda, kontrol grubuna göre (sırası ile 196,222 ve 222,639 p=0,003) anlamlı olarak düşük bulundu). OPH, HELLP sendromu grubunda kontrol grubuna göre (sıra ile 9,95 ve 11,13, p=0,04) anlamlı olarak düşük bulundu.
Sonuç: Çalışmamızda inflamatuar belirteçlerden NLO’nun artışının ve PLO ve OPH’nin azalmasının hem HELLP sendromu tanısında hem de HELLP sendromu ile PE ayrımında kullanılabileceği sonucuna ulaşıldı
Bilateral Lenticule Creation Followed by Bilateral Lenticule Separation Improves Visual Outcomes After SMILE
Authors: Ma Jiaonan , Wang Yan , Jhanji Vishal 
Published: November 2021

PURPOSE:
To explore the impact of different surgical sequences on the visual and refractive outcomes of bilateral small incision lenticule extraction (SMILE) surgery using propensity score matching (PSM) analysis.

METHODS:
Participants who underwent uneventful SMILE between March 2018 and September 2019 were retrospectively analyzed and were divided into two groups: Sequence A (laser scanning [LS] of the right eye, manual separation lenticule [MSL] of the right eye, and LS and MSL of the left eye) and Sequence B (LS of the right eye, LS of the left eye, MSL of the left eye, and MSL of the right eye). PSM was conducted to minimize the effect of confounding factors on postoperative visual outcomes at days 1 and 7 and months 1, 3, and 6. Safety, efficacy, predictability, and stability were compared between groups.

RESULTS:

Overall, 1,854 eyes of 927 participants were included (Sequence A, n = 280; Sequence B, n = 647). After PSM, there were no significant differences in baseline characteristics, and 534 eyes (267 patients) in the Sequence A group were matched (1:1) to the Sequence B group. The postoperative corrected distance visual acuity significantly differed between groups at 3 months (adjusted
P
= .007). The uncorrected distance visual acuity significantly differed between groups at all follow-up visits (adjusted
P
< .01). The safety index (1.341 ± 0.265 and 1.413 ± 0.294) and efficacy index (1.173 ± 0.191 and 1.251 ± 0.269) were different in the Sequence A and Sequence B groups, respectively, at 3 months (adjusted
P
< .01). No difference in visual outcomes was found between right and left eyes.

CONCLUSIONS:
Patients who had bilateral lenticule creation followed by bilateral lenticule separation had better postoperative visual outcomes than those who underwent complete SMILE surgery in each eye separately. Regardless of the surgical sequence chosen for the SMILE procedure, there was no impact on outcomes between the right and left eyes. Adjusting the sequence of the surgical procedure may be a way to improve the visual results.

[
J Refract Surg
. 2021;37(11):726–733.]
Should Artificial Tears Be Used During the Preoperative Assessment of Toric IOLs Before Age-Related Cataract Surgery? The TORIDE Study
Authors: Rochet Elsa , Levron Antoine , Agard Emilie , Chehab Hussam El , Plas Hélène , Bouvarel Hugo , Chirpaz Nicolas , Billant Jérémy , Dot Corinne 
Published: November 2021

PURPOSE:
To assess the impact of the use of artificial tears during the preoperative work-up performed before age-related cataract surgery, when a toric intraocular lens (IOL) was indicated.

METHODS:
This was a monocentric prospective study assessing 73 eyes of 51 patients, included consecutively after a preoperative work-up performed without artificial tears (no artificial tears group), when a toric IOL was indicated. Each included patient underwent a second series of examinations: biometry using the IOLMaster 700 (Carl Zeiss Meditec AG) and topography using the OPD-Scan II (Nidek), 1 minute after artificial tears instillation (artificial tears group; hyaluronate de sodium 0.15%, threalose 3% [Théalose; Théa]). Changes in anterior corneal astigmatism and subsequent changes in toric IOL calculation were analyzed. The error in predicted residual astigmatism was calculated.

RESULTS:

Anterior corneal astigmatism and total corneal astigmatism measured with the IOLMaster 700 were significantly modified when artificial tears were instilled before the examinations (1.51 ± 0.57 diopters [D], range: 0.75 to −3.55 vs 1.42 ± 0.63 D, range: 0.42 to 3.35 D;
P
= .043 and 1.59 ± 0.54 D, range: 0.87 to 3.48 vs 1.51 ± 0.59 D, range: 0.56 to 3.27 D,
P
= .038, respectively). This modification led to a change in IOL cylinder calculation in 43.8% of cases and to a change in implantation axis greater than 10° in 17.7% of cases. These changes were significantly greater in patients with a breakup time (BUT) less than 5 seconds (57.5% and 27.8%, with
P
= .009 and .029, respectively). In the subgroup of patients with a BUT of less than 5 seconds, the mean absolute error in predicted astigmatism was significantly lower after artificial tears instillation (0.48 ± 0.50 D, range: 0.00 to 2.79 vs 0.37 ± 0.25 D, range: 0.00 to 1.10 D,
P
= .048).

CONCLUSIONS:
Dry eye significantly impacted toric IOL calculations and should be taken into account during the preoperative assessments. Using artificial tears reduced the number of refractive errors.

[
J Refract Surg
. 2021;37(11):759–766.]