bluuebunny/crossref_metadata_2025_split huggingface dataset:
About 4-day Rhythm of Proliferative Activity of Fibroblast-like Cell Cultures Depends on the Environmental Factor
Authors: Diatroptova Marina A. , Kosyreva Anna M. , Diatroptov Mikhail E. 
Published: November 2021

Abstract
A study of the 4-day rhythm of the proliferative activity of the embryonic fibroblast-like cells in the logarithmic growth phase was carried out. It was shown that in cell cultures obtained on different days from embryos of different ages, the phase of the 4-day rhythm coincides. In vitro the maxima of the proliferative activity were consistent with the minima of the motor activity of mice. Freezing the culture for 2 or 6 days does not cause a shift in the phase of the 4-day rhythm of cell proliferative activity compare with the unfreezing culture. That indicates the existence of an external synchronizer, which determines the 4-day infradian rhythm of the proliferative activity of embryonic cells. Then we daily thawed samples of single L-929 culture of mice fibroblast-like cells for 22 and 17 days and researched the dynamics of its proliferative activity. We also showed 4-day rhythm of the simultaneous increase in the number of cells for all thawed samples. Taking into account that deep freezing of a culture leads to the cessation of all life processes, the fact we obtained indicates an exogenous mechanism of the formation of about a 4-day rhythm of the proliferative activity of cell culture.
Drivers, Facilitators, and Sources of Stigma Among Akha and Lahu Hill Tribe People who used Methamphetamine in Thailand: A Qualitative Approach
Authors: Udplong Anusorn , Apidechkul Tawatchai , Sric Peeradone , Mulikaburt Thanatchaporn , Wongnuch Pilasinee , Kitchanapaibul Siwarak , Upala Panupong , Chomchoei Chalitar , Yeemard Fartima , Tamornpark Ratipark , Singkhorn Onnalin 
Published: November 2021

Abstract
Background: The stigma related to drug use has several impacts, including effects on users’ physical and mental health. Methamphetamine is the major drug that is used among hill tribes living in the border areas of Thailand and Myanmar. This study aimed to understand the drivers, facilitators, sources and outcomes of the stigma surrounding drug use, including the expectations among Akha and Lau hill tribe people who use methamphetamine in Thailand.Methods: Qualitative data were used to elicit information from the key informants, members of the hill tribes who used methamphetamine. Questions guild was developed from a literature review and tested for validity before use. In-depth interviews were used to gather information confidentially from the participants in private rooms in villages. Each interview lasted 45 minute, and a thematic analysis was conducted to examine the findings.Results: A total of 46 participants were recruited to provide information; 95.7% were male, and 50.0% were aged between 15-34 years. The majority were married (47.8%), 76.1% were Christian, and 45.7% graduated high school. Six drivers of stigma were detected, being: poor, illiterate, unemployed, working age, female sex, and marital status. Culture and tribe acted as facilitators of the stigma attached to methamphetamine use. Four sources of stigma were found: self, family members, peers, and community members. Three outcomes stigma were determined, poor: physical health, mental health, and relationships with others. There were four levels of expectations: no expectations, expectations for themselves, expectations for their family members, and expectations for their community members.Conclusions: Many personal traits, people living nearby, and socioeconomic factors, including culture and tribes, act as drivers, facilitators, and sources of stigma among hill tribe people who use methamphetamine. A program to reduce methamphetamine use among hill tribes should be implemented, which could eventually minimize stigma.
Impact of Same Day Screening Mammogram Results on Patient Satisfaction and Overall Breast Cancer Screening Experience - A Quality Improvement Survey Analysis
Authors: Shah Biren A. , Mirchandani Anicia , Abrol Srishti 
Published: November 2021

Abstract
Background: An increasing number of breast cancer cases and associated mortality due to delayed diagnosis warrants improved methods to provide a timely and convenient breast cancer screening experience.Objective: To study the impact of same appointment mammogram results on breast cancer screening experience and patient satisfaction.Materials and methods: A 6-question survey with questions focused on breast cancer screening experience with our new service of same appointment mammogram results was distributed to 200 patients, with 185 patients returning their responses. Patients evaluated their current experience on receiving their screening results during the same appointment with their prior breast cancer screening experience. Patients who did not respond to their satisfaction score either before or after same appointment results were excluded from the patient cohort analyzing satisfaction score. Remaining questions were analyzed separately as additional satisfaction assessment tools.Results: About 48% of the patients indicated an improvement in their screening experience with same appointment mammography results service, while 47% of the patients reported no significant difference in their experience.Conclusion: Although not statistically significant, same appointment mammogram results were able to make a positive impact on breast cancer screening experience among 48% of the patients. Further research elucidating barriers to screening and other ways to improve patient satisfaction will be required to increase breast cancer screening compliance.
Rigid-Flexible Coupling Fatigue Life Reliability Study on Bonic Fish Driving Shaft
Authors: LI Ming-hao , QIAO Jie , ZHAO Li-juan 
Published: November 2021

Abstract
Due to the complex loads on a bionic robotic fish operating underwater, the reliability of its working mechanism has an important effect on its overall performance. By establishing a virtual prototype model for the rigid–flexible coupling of a bionic robotic fish, we obtained the instantaneous load on the caudal fin of the robotic fish based on the flapping-wing propulsion theory with MATLAB. A rigid–flexible coupled virtual prototype model for the caudal fin drive as a flexible member of the bionic robotic fish was established, and dynamic simulations were conducted on the model. The simulations revealed the weak links in the drive shaft and established a damage level indicator and fatigue reliability analysis method based on damage theory. The behavior of fatigue reliability for different stress cycles was established, and a dynamic reliability design method with great engineering application value was proposed for virtual prototypes of rigid–flexible coupled underwater bionic robots by combining the virtual prototype technology of rigid–flexible coupling with the theory of flapping wing propulsion and the theory of random load fatigue reliability.
Sliding Mode Control of Interval Type-2 T-S Fuzzy Systems with Redundant Channels
Authors: Zhang Zhina , Niu Yugang 
Published: November 2021

Abstract
This paper investigates the sliding mode control (SMC) of interval type-2 (IT2) T-S fuzzy systems. The measurement outputs are propagated via redundant channels for reducing the probability of packet loss and improving the reliability of data transmission. A key feature for the above problem is that the premise variables and the measurement signals may not be available by the controller, which brings difficulty to stabilize the nonlinear systems. Accordingly, a crucial issue is how to synthesize an implementable SMC law under the redundant channels. To this end, the characteristic of the redundant channels is firstly analyzed and the model of available measurement output signals is established. By employing these available measurements as the premise variables and utilizing the upper and lower bounds of the system membership functions (MFs), new MFs are constructed and the sliding mode controller is synthesized. By introducing some null terms carrying the information of MFs, sufficient conditions are derived in terms of nonlinear matrix inequalities to ensure the stochastically ultimate boundedness of the closed-loop system and the reachability of the specified sliding surface. Besides, a binary genetic algorithm (GA) is introduced to solve the nonlinear criteria via the objective function reflecting the control performance. Finally, a numerical example illustrates the effectiveness of the proposed methods.
Analysis of the Expression and Clinical Significance of VIPR1 in Lung Adenocarcinoma Based on TCGA Database
Authors: Li Xiaobo , Wang Yunfei , Wei Xiaowan , Zhang Guojun , Wang Huaqi 
Published: November 2021

Abstract
Background: The expression of VIPR1 is associated with the prognosis of many malignant tumors. To analyze the expression and clinical significance of vasoactive intestinal peptide Types I (VIPR1) in lung adenocarcinoma based on The Cancer Genome Atlas (TCGA)database. Methods and results：The RNASeq data, clinical data and prognosis data of lung adenocarcinoma and normal lung tissue were downloaded from TCGA database. The expression difference of VIPR1 mRNA in lung adenocarcinoma and normal lung tissue（p<0.05）, and the correlations of the expression levels of VIPR1 in lung adenocarcinoma with clinical pathological characteristics and prognosis were analyzed. The possible regulatory signaling pathways of VIPR1 were predicted by the gene set enrichment analysis (GSEA). CIBERSORT was used to analyze the expression of immune cells in tumor tissues and normal tissues. TIMER was used to analyze the relationship between VIPR1 and immune cell expression. The expression levels of VIPR1 mRNA in lung adenocarcinoma tissues were significantly lower than that in normal lung tissues. The expression levels of VIPR1 mRNA were significantly correlated with gender, T staging，N staging and pathological grade（p<0.05）but not with age, M staging and survival status. Survival analysis showed that the survival time of patients with low expression of VIPR1 was significantly lower than that of patients with high expression. In addition, the expression level of VIPR1 in lung adenocarcinoma was negatively correlated with the infiltration level of myeloid inhibitory cells (r = -0.448, p < 0.01). Through GSEA functional enrichment analysis, it was found that VIPR1 was mainly related to cell cycle pathway, p53 signal pathway, DNA replication pathway, RNA degradation pathway and so on.Conclusions：VIPR1 gene may be a new target for the clinical prognosis and targeted therapy of lung adenocarcinoma.
Associations Between Dietary Inflammatory Index Scores And The Increased Disease Activity of Rheumatoid Arthritis: A Cross-Sectional Study
Authors: Nayebi Atiyeh , Soleimani Davood , Mostafaei Shayan , Elahi Negin , Pahlavani Naseh , Bagheri Amir , Elahi Homayoun , Mahmoudi Mahdi , Nachvak Seyed Mostafa 
Published: November 2021

Abstract
Background: Diet plays an important role in regulating inflammation, which is a hallmark of rheumatoid arthritis (RA). Our aim was to investigate the association between the inflammatory potential of diet and RA activity.Methods: This cross-sectional study was conducted on 184 patients with RA in rheumatology clinic in Kermanshah city, Iran, in 2020. RA was diagnosed according to the criteria of the 2010 American College of Rheumatology/ European League against Rheumatism. The overall inflammatory potential of the diet was extracted from a validated 168-item food frequency questioner (FFQ) using the Dietary Inflammatory Index (DII). RA disease activity was assessed using Disease Activity Score 28 (DAS28) scores. Logistic regression and one-way ANOVA/ ANCOVA were conducted. Results: Individuals in the highest DII quartile had the significantly higher odds of positive C-reactive protein (CRP) than those in the lowest quartile of the DII scores (OR: 4.5; 95% CI: 1.16 – 17.41; P-value: 0.029). A statistically significant downward linear trend in fat-free mass and weight were observed with increasing the DII quartiles (P-value=0.003, P-value=0.019, respectively). Patients in the highest DII quartile had higher DAS 28 scores than those in the first quartile (Mean difference: 1.16; 95% CI: 0.51 – 1.81; P-value <0.001) and second quartile of the DII scores (Mean difference: 1.0; 95% CI: 0.34 – 1.65; P-value <0.001).Conclusion: Our results indicated that reducing inflammation through diet might be one of the therapeutic strategies to control and reduce the disease activity in RA patients.
Alternative Labeling Tool: a minimal algorithm for denoising single-subject resting-state fMRI data with ICA-MELODIC
Authors: Zhukovsky Peter , Coughlan Gillian , Dickie Erin W , Hawco Colin , Voineskos Aristotle N 
Published: November 2021

Abstract
Subject-level independent component analysis (ICA) is a well-established and widely used approach in denoising of resting-state functional magnetic resonance imaging (fMRI) data. However, approaches such as ICA-FIX and ICA-AROMA require advanced setups and/or are computationally intensive. Here, we aim to introduce a user-friendly, computationally lightweight toolbox for labeling independent signal and noise components, termed Alternative Labeling Tool (ALT). ALT uses two features that require manual tuning: proportion of an independent component’s spatial map located inside gray matter and positive skew of the power spectrum. ALT is tightly integrated with the commonly used FMRIB’s statistical library (FSL). Using the Open Access Series of Imaging Studies (OASIS-3) ageing dataset (n=30), we found that ALT shows a high degree of inter-rater agreement with manual labeling (over 86% of true positives for both signal and noise components on average). Crucially, denoising using ALT-generated labels significantly reduced mean framewise displacement (p<0.001). In conclusion, ALT can be extended to small and large-scale datasets when the use of more complex tools such as ICA-FIX is not possible. ALT will thus allow for more widespread adoption of ICA-based denoising of resting-state fMRI data.
Spatial and Temporal Variations of Climate on Different Flanks and Elevations in the Qinling-Daba Mountains of China from 1969 to 2018
Authors: Lan Xincan , Li Wuyang , Tang Jiale , Shakoor Abdul , Zhao Fang , Fan Jiabin 
Published: November 2021

Abstract
Climate change presents great variations on different flanks and elevations in the same mountain range. Analysis of the spatial and temporal variations of climate on different flanks and elevations in the north-south transition zone--the Qinling-Daba Mountains (QDM) are of great significance for exploring the complexity of climate geography pattern and phenology in China. This paper collected 118 weather stations data on daily temperature and precipitation during 1969-2018 from the National Meteorological Information Center, and then explored the temporal and spatial distribution characteristics of climate on different flanks and elevations. The results showed that: 1) On the whole, there was a significant warming trend in the four seasons in the past 50 years. Precipitation did not show significant variation at most stations with an exception to 8 weather stations having significant changes in trend in different seasons. 2) The temperature showed an increasing trend in different seasons, but its increasing rate varied greatly on different flanks. Generally speaking, climate change was greater on the northern flanks than that on the southern flanks in the four seasons in the QDM. Temperature tendency is greater in spring and winter than in summer and autumn on different flanks in the QDM. 3) The increase rate of temperature varied greatly at different elevations in different seasons. The warming rate was greater in the higher altitude regions than that of the lower altitude regions in summer, autumn and winter, while, in spring, however, it is higher in the lower altitudes than in the higher altitudes.
What Older Patients and their Relatives Say is Important During Acute Hospitalisation: A Qualitative Study
Authors: Weldingh Nina Mickelson , Kirkevold Marit 
Published: November 2021

Abstract
Background: Due to the growing elderly population across the world, providing safe and effective care to older people is an increasing concern. Hospitals need to adapt to ensure high-quality care for older patients. Several age-friendly frameworks and models aiming at reducing risks and complications have been promoted. However, care for the elderly must be based on the patients’ reported needs, and relatives are often an important part of the patients’ resources. The primary aim of this study was to explore elderly patients’ and their relatives’ experiences of acute hospitalisation and determine what is important for them to experience a good hospital stay. Methods: This study has a qualitative research design in which patients aged 75 years or older and their relatives were interviewed during their acute hospitalisation. The study was conducted at two medical bed wards at a large university hospital in Norway. All interviews were thematically analysed.Results: Four major themes were identified in patients’ and relatives’ descriptions of how they experienced the hospital stay and what was important for them during the hospital stay: being seen and valued as a person, individualised care, patient-adapted communication and information, and collaboration with relatives. The themes span both positive and negative experiences, reflecting great variability in the experiences described.Conclusions: The results underscore how small things matter in relation to how we meet and communicate with older patients and their relatives. How health personnel get to know the patient’s individual values, need for care, information and involvement of relatives affects their experiences of the hospital stay.
Nonvolatile ferroelectric domain wall memory integrated on silicon
Authors: Nie Yuefeng , Sun Haoying , Wang Jierong , Wang Yushu , Gu Jiahui , Yang Jiangfeng , Liu Yuwei , Gao Tianyi , Fu Hanyu , Hao Yufeng , Gu Zhenbin 
Published: November 2021

Abstract
Ferroelectric domain wall memories have been proposed as a promising candidate for nonvolatile memories, given their intriguing advantages including low energy consumption and high-density integration. Perovskite oxides possess superior ferroelectric prosperities but perovskite-based domain wall memory integrated on silicon has rarely been reported due to the technical challenges in the sample preparation. Here, we demonstrate a domain wall memory prototype utilizing freestanding BaTiO3 membranes transferred onto silicon. While as-grown BTO films on (001) SrTiO3 substrate are purely c-axis polarized, we find they exhibit distinct in-plane multidomain structures after released from the substrate and integrated onto silicon due to the collective effects from depolarizing field and strain relaxation. Based on the strong in-plane ferroelectricity, conductive domain walls with reading currents reaching 2 nA are observed and can be created artificially, highlighting the great potential of the integration of perovskite oxides with silicon for ferroelectric domain wall memories.
Quantum-assisted distortion-free audio signal sensing
Authors: Zhang Chen , Dasari Durga , Widmann Matthias , Meinel Jonas , Vorobyov Vadim , Kapitanova Polina , Nenasheva Elizaveta , Nakamura Kazuo , Sumiya Hitoshi , Onoda Shinobu , Isoya Junichi , Wrachtrup Jörg 
Published: November 2021

Abstract
Quantum sensors are keeping the cutting-edge sensitivities in metrology. However, for high-sensitive measurements of arbitrary signals, limitations in linear dynamic range could introduce distortions when sensing the frequency, magnitude and phase of unknown signals. Here, we overcome these limitations with advanced sensing protocol that combines quantum phase-sensitive detection with the heterodyne readout. We present theoretical and experimental investigations using nitrogen-vacancy centers in diamond, showing the ability to sense audio signals with a 98 dB linear dynamic range, a 31 pT/Hz1/2 sensitivity, and arbitrary frequency resolution. Further, we perform the quantum-assisted distortion-free audio signal (melody, speech) sensing with high fidelity. The methods developed here could broaden the horizon for quantum sensors towards applications in telecommunication, where high-fidelity and low-distortion at multiple frequency bands within small sensing volumes are required.
Precision Allocation Method of Large-Scale CNC Hobbing Machine Based On Precision-Cost Comprehensive Optimization
Authors: Hu Zongyan , Wang Shilong , Ma Chi 
Published: November 2021

Abstract
In modern machine tool design, precision is an important index to characterize machine tool performance. and precision allocation has become a key task. Since middle 20th century, the precision allocation method using optimization technology to balance manufacturing cost and quality has gradually developed. But most methods mainly take the cost minimization as the goal to optimize the precision allocation. As the precision and manufacturing cost are a pair of factors to be comprehensively considered, balance between them is needed to meet different design requirements. This paper proposes a comprehensive optimization method to trade-off between precision and cost. A multi-object precision allocation optimization model aiming at minimizing fuzzy manufacturing cost and comprehensive precision of machine tool is constructed. A multi-object optimization algorithm to solve the model is designed, combining the multi-objective grey wolf optimization algorithm with multi-objective decision analysis method TOPSIS. A case study based on a large-scale hobbing machine shows that the comprehensive optimization of manufacturing cost and machining precision is realized by using the proposed multi-object precision allocation optimization method.