bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visualizing risk factors of dementia from scholarly literature using knowledge maps and next-generation data models
Authors: Fahd Kiran , Venkatraman Sitalakshmi 
Published: June 2021

AbstractScholarly communication of knowledge is predominantly document-based in digital repositories, and researchers find it tedious to automatically capture and process the semantics among related articles. Despite the present digital era of big data, there is a lack of visual representations of the knowledge present in scholarly articles, and a time-saving approach for a literature search and visual navigation is warranted. The majority of knowledge display tools cannot cope with current big data trends and pose limitations in meeting the requirements of automatic knowledge representation, storage, and dynamic visualization. To address this limitation, the main aim of this paper is to model the visualization of unstructured data and explore the feasibility of achieving visual navigation for researchers to gain insight into the knowledge hidden in scientific articles of digital repositories. Contemporary topics of research and practice, including modifiable risk factors leading to a dramatic increase in Alzheimer’s disease and other forms of dementia, warrant deeper insight into the evidence-based knowledge available in the literature. The goal is to provide researchers with a visual-based easy traversal through a digital repository of research articles. This paper takes the first step in proposing a novel integrated model using knowledge maps and next-generation graph datastores to achieve a semantic visualization with domain-specific knowledge, such as dementia risk factors. The model facilitates a deep conceptual understanding of the literature by automatically establishing visual relationships among the extracted knowledge from the big data resources of research articles. It also serves as an automated tool for a visual navigation through the knowledge repository for faster identification of dementia risk factors reported in scholarly articles. Further, it facilitates a semantic visualization and domain-specific knowledge discovery from a large digital repository and their associations. In this study, the implementation of the proposed model in the Neo4j graph data repository, along with the results achieved, is presented as a proof of concept. Using scholarly research articles on dementia risk factors as a case study, automatic knowledge extraction, storage, intelligent search, and visual navigation are illustrated. The implementation of contextual knowledge and its relationship for a visual exploration by researchers show promising results in the knowledge discovery of dementia risk factors. Overall, this study demonstrates the significance of a semantic visualization with the effective use of knowledge maps and paves the way for extending visual modeling capabilities in the future.
Study of HOTAIR LncRNA in AML patients in context to FLT3-ITD and NPM1 mutations status
Authors: Salah Mona , Zawam Hamdy , Fouad Neven Bahaa , Soliman Nohair , Maksoud Fatma Abdel Wahab Abdel 
Published: June 2021

Abstract
Background
Long non-coding RNAs (LncRNAs) have recently been considered promising biomarkers for oncogenesis due to their epigenetic regulatory effects. HOTAIR is one of the oncogenic LncRNAs that was previously studied in different non-hematological malignancies. The current study set out to detect the expression level of HOTAIR LncRNA in AML patients concerning their clinical characteristics, laboratory data, FLT3-ITD, and NPM1 mutations, as well as treatment outcome. This study included quantitative detection of HOTAIR gene expression in 47 cases of AML using quantitative reverse transcription polymerase chain reaction, as well as NPM1 and FLT3-ITD genotyping.

Results
The HOTAIR expression was significantly higher in AML patients 6.87 (0.001) than in normal controls 1.66 (0.004–6.82) (p 0.007). The HOTAIR expression level was affected by chemotherapy, and it was correlated to hemoglobin level (p 0.001), age, total leukocytic count (p 0.022), and NPM1 mutation (p 0.017). HOTAIR gene expression level showed a correlation to relapse-free survival in the study group (p 0.04).

Conclusion
HOTAIR is overexpressed in patients with acute myeloid leukemia (AML). HOTAIR pre-treatment and post-chemotherapy gene expression levels can predict chemosensitivity and relapse.
Genomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report From an International Consortium
Authors: Shern Jack F. , Selfe Joanna , Izquierdo Elisa , Patidar Rajesh , Chou Hsien-Chao , Song Young K. , Yohe Marielle E. , Sindiri Sivasish , Wei Jun , Wen Xinyu , Rudzinski Erin R. , Barkauskas Donald A. , Lo Tammy , Hall David , Linardic Corinne M. , Hughes Debbie , Jamal Sabri , Jenney Meriel , Chisholm Julia , Brown Rebecca , Jones Kristine , Hicks Belynda , Angelini Paola , George Sally , Chesler Louis , Hubank Michael , Kelsey Anna , Gatz Susanne A. , Skapek Stephen X. , Hawkins Douglas S. , Shipley Janet M. , Khan Javed 
Published: June 2021

PURPOSE Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood. Despite aggressive therapy, the 5-year survival rate for patients with metastatic or recurrent disease remains poor, and beyond PAX-FOXO1 fusion status, no genomic markers are available for risk stratification. We present an international consortium study designed to determine the incidence of driver mutations and their association with clinical outcome. PATIENTS AND METHODS Tumor samples collected from patients enrolled on Children's Oncology Group trials (1998-2017) and UK patients enrolled on malignant mesenchymal tumor and RMS2005 (1995-2016) trials were subjected to custom-capture sequencing. Mutations, indels, gene deletions, and amplifications were identified, and survival analysis was performed. RESULTS DNA from 641 patients was suitable for analyses. A median of one mutation was found per tumor. In FOXO1 fusion-negative cases, mutation of any RAS pathway member was found in > 50% of cases, and 21% had no putative driver mutation identified. BCOR (15%), NF1 (15%), and TP53 (13%) mutations were found at a higher incidence than previously reported and TP53 mutations were associated with worse outcomes in both fusion-negative and FOXO1 fusion-positive cases. Interestingly, mutations in RAS isoforms predominated in infants < 1 year (64% of cases). Mutation of MYOD1 was associated with histologic patterns beyond those previously described, older age, head and neck primary site, and a dismal survival. Finally, we provide a searchable companion database ( ClinOmics ), containing all genomic variants, and clinical annotation including survival data. CONCLUSION This is the largest genomic characterization of clinically annotated rhabdomyosarcoma tumors to date and provides prognostic genetic features that refine risk stratification and will be incorporated into prospective trials.
Effect of boundary conditions in turbulent thermal convection
(a)
Authors: Urban P. , Králík T. , Macek M. , Hanzelka P. , Věžník T. , Skrbek L. 
Published: June 2021

Abstract
We report an experimental study aiming to clarify the role of boundary conditions (BC) in high Rayleigh number

turbulent thermal convection of cryogenic helium gas. We switch between BC closer to constant heat flux (CF) and constant temperature (CT) applied to the highly conducting bottom plate of the aspect-ratio-one cylindrical cell 30 cm in size, leading to dramatic changes in the temperature probability density function and in power spectral density of the temperature fluctuations measured at the bottom plate, while the dynamic thermal behaviour of the top plate and bulk convective flow remain unaffected. Within our experimental accuracy, we find no appreciable changes in Reynolds number Re(Ra) scaling, in the dimensionless heat transfer efficiency expressed via Nusselt number Nu(Ra) scaling, nor in the rate of direction reversals of large scale circulation.
Effects of Lorentz symmetry violation on a relativistic scalar particle in quantum systems
Authors: Ahmed Faizuddin 
Published: June 2021

Abstract
In this paper, the relativistic quantum dynamics of a scalar particle under the effect of Lorentz symmetry violation determined by a tensor

out of the Standard Model Extension is investigated. We see that the bound-state solutions of the modified Klein-Gordon equation can be obtained, and the spectrum of energy and the wave function depends on the Lorentz symmetry breaking parameters.
Stochastic entropies and fluctuation theorems for a generic 1D KPZ system: Internal and external dynamics
Authors: Rodríguez Miguel A. , Gallego Rafael , Wio Horacio S. 
Published: June 2021

Abstract
In a recent numerical study, we have analyzed the stochastic entropies and fluctuation theorems in a 1D KPZ system. Such a study only considered saturated fluctuations around the spatial mean value of the interface. In this way stationary solutions exist and besides, with some particular discrete version, those solutions are exactly known. In this paper we extend these previous results in two ways. On the one hand, the dynamics of the spatial mean value is taken into account. We then distinguish between the entropies associated with internal fluctuations (of the interface around the spatial mean), and external fluctuations (of the spatial mean around the sample mean) dynamics. On the other hand, a broader region of parameters is analysed. Two distinct behaviors appear depending on whether after saturation the system overcomes the Edward-Wilkinson crossover towards the KPZ regime or not.
Body, Bones, and All
Authors: Goswami Uddipana 
Published: June 2021

Abstract
A reflection on the different forms that violence against women takes in militarized societies like that in Assam in Northeast India. A young girl living with an abusive father is married off to an abusive husband. Like other women living with quotidian violence, she devises coping mechanisms: often the lines between reality and fantasy become blurred. The unbearable burden of a life abused (and its grim ending) can be made bearable only through recourse in the unreal and the magical.
Afro-Asian Peoples’ Solidarity Organization (AAPSO) Presidium Committee Nairobi Preparations
Authors: Wiley-Yancy Destiny 
Published: June 2021

Abstract
The Afro-Asian People’s Solidarity Organization’s (AAPSO) Presidium Committee on Women met to prepare for the United Nations Conference on Women in Nairobi, Kenya. The committee aimed to tackle the impact of colonialism and imperialism and the ways they disproportionately impacted the lives of women. The AAPSO wanted to do this through a series of workshops focusing on the status of women in apartheid South Africa, the destabilization of women and children in Africa and Asia, the burden of debt in developing countries, and the subversive role of transnational corporations in mass media. The committee also recognized that women, particularly in Africa and Asia, formed the forefront of resistance movements, driving the struggle. This meeting shows that the Presidium Committee on Women optimistically saw women’s social justice as an integral component to the larger anticolonial and anti-imperial project.
Electrically injected InGaAsP/AlGaAs optical parametric oscillator: design and technology
Authors: Gerini Andrea , Ravaro Marco , Théveneau Claire , Garcia Michel , Gérard Bruno , Krakowski Michel , Leo Giuseppe 
Published: June 2021

We propose an original architecture for a monolithic electrically injected optical parametric oscillator based on a high-power distributed feedback laser diode and a nonlinear waveguide. In the epitaxial structure, the two optical cavities are set apart to avoid free carrier loss for the nonlinear interaction and coupled through a vertical modal converter. We discuss the constitutive elements of the device for which we estimate a parametric oscillation threshold of the order of 1 mW.
Mycophenolate mofetil versus azathioprine in kidney transplant recipients on steroid-free, low-dose cyclosporine immunosuppression (ATHENA): A pragmatic randomized trial
Authors: Ruggenenti Piero , Cravedi Paolo , Gotti Eliana , Plati Annarita , Marasà Maddalena , Sandrini Silvio , Bossini Nicola , Citterio Franco , Minetti Enrico , Montanaro Domenico , Sabadini Ettore , Tardanico Regina , Martinetti Davide , Gaspari Flavio , Villa Alessandro , Perna Annalisa , Peraro Francesco , Remuzzi Giuseppe 
Published: June 2021

Background
We compared protection of mycophenolate mofetil (MMF) and azathioprine (AZA) against acute cellular rejection (ACR) and chronic allograft nephropathy (CAN) in kidney transplant recipients on steroid-free, low-dose cyclosporine (CsA) microemulsion maintenance immunosuppression.

Methods and findings
ATHENA, a pragmatic, prospective, multicenter trial conducted by 6 Italian transplant centers, compared the outcomes of 233 consenting recipients of a first deceased donor kidney transplant induced with low-dose thymoglobulin and basiliximab and randomized to MMF (750 mg twice/day, n = 119) or AZA (75 to 125 mg/day, n = 114) added-on maintenance low-dose CsA microemulsion and 1-week steroid. In patients without acute clinical or subclinical rejections, CsA dose was progressively halved. Primary endpoint was biopsy-proven CAN. Analysis was by intention to treat.
Participants were included between June 2007 and July 2012 and followed up to August 2016. Between-group donor and recipient characteristics, donor/recipient mismatches, and follow-up CsA blood levels were similar. During a median (interquartile range (IQR)) follow-up of 47.7 (44.2 to 48.9) months, 29 of 87 biopsied patients on MMF (33.3%) versus 31 of 88 on AZA (35.2%) developed CAN (hazard ratio (HR) [95% confidence interval (CI)]: 1.147 (0.691 to 1.904, p = 0.595). Twenty and 21 patients on MMF versus 34 and 14 on AZA had clinical [HR (95% CI): 0.58 (0.34 to 1.02); p = 0.057) or biopsy-proven subclinical [HR (95% CI): 1.49 (0.76 to 2.92); p = 0.249] ACR, respectively. Combined events [HR (95% CI): 0.85 (0.56 to 1.29); p = 0.438], patient and graft survival, delayed graft function (DGF), 3-year glomerular filtration rate (GFR) [53.8 (40.6;65.7) versus 49.8 (36.8;62.5) mL/min/1.73 m2, p = 0.50], and adverse events (AEs) were not significantly different between groups.
Chronicity scores other than CAN predict long-term graft outcome. Study limitations include small sample size and unblinded design.

Conclusions
In this study, we found that in deceased donor kidney transplant recipients on low-dose CsA and no steroids, MMF had no significant benefits over AZA. This finding suggests that AZA, due to its lower costs, could safely replace MMF in combination with minimized immunosuppression.

Trial registration
ClinicalTrials.gov NCT00494741; EUDRACT 2006-005604-14.
Vancomycin resistant Enterococci and its associated factors among HIV infected patients on anti-retroviral therapy in Ethiopia
Authors: Regasa Dadi Belayneh , Solomon Zerihun , Tesfaye Mheret 
Published: June 2021

BackgroundThe emergence of vancomycin resistant Enterococci (VRE) has alarmed the global community due to its tendency for colonization of the gastrointestinal tract. Human Immunodeficiency Virus (HIV) patients are colonized by vancomycin resistant Enterococci than other groups. The aim of this study was to determine the incidence of vancomycin resistant Enterococci and its associated factors among HIV infected patients on Anti-Retroviral Therapy (ART).MethodsInstitution based cross sectional study was conducted among HIV infected patients on ART at from June 1 to August 30, 2020. Socio-demographic and clinical data were collected by pre-tested structured questionnaire. Stool sample was collected and processed by standard microbiological techniques. Kirby Bauer Disc diffusion method was used to perform antimicrobial susceptibility testing. Data were entered by Epi data version 4.6.0.2 and analyzed by SPSS version 25. Bivariable and multivariable logistic regression model was used to analyze the association between dependent and independent variables. P-values in the multivariable analysis, adjusted odds ratio (AOR) and 95% confidence interval (CI) were used to determine the strength of association. P-value ≤0.05 was considered as significant.ResultsEnterococcispp was isolated on 123/200 (61.50%) patients. Among these isolates, the incidence of vancomycin resistant Enterococci was 11.4% [95% CI: (6.0–17.0)]. Antimicrobial susceptibility patterns againstEnterococcishowed highest rate of resistance to ampicillin (69.9%). Multidrug resistances were observed in 49.59% ofEnterococciisolates. Study participants who had prior antibioticexposurer more than two weeks [AOR = 7.35; 95% CI: (1.2144.64)] and hospitalization for the last six months [AOR = 5.68; 95% CI: (1.09 29.74)] were significantly associated with vancomycin resistantEnterococci.ConclusionsIn our study high incidence of vancomycin resistantEnterococciwas found. Previous exposure to antibiotics for more than two weeks and hospitalization for more than six months were significantly associated with vancomycin resistantEnterococci. The isolatedEnterococcihad variable degrees of resistance to commonly prescribed antibiotics. Therefore, periodic surveillance on antimicrobial resistance pattern, adhering to rational use of antibiotics and implementing infection prevention protocols may reduce colonization by VRE.
Association between specific antiarrhythmic drug prescription in the post-procedural blanking period and recurrent atrial arrhythmias after catheter ablation for atrial fibrillation
Authors: Malladi Chaitanya L. , Darden Douglas , Aldaas Omar , Mylavarapu Praneet S. , Eskander Michael , Lupercio Florentino , Han Frederick T. , Hoffmayer Kurt S. , Raissi Farshad , Ho Gordon , Krummen David , Feld Gregory K. , Hsu Jonathan C. 
Published: June 2021

Purpose
To evaluate if specific AADs prescribed in the blanking period (BP) after catheter ablation of atrial fibrillation (AF) may be associated with reduced risk of early recurrence (ER) and/or late recurrence (LR) of atrial arrhythmias.

Methods
A total of 478 patients undergoing first-time ablation at a single institution were included. Outcomes were: ER, LR, discontinuation of AAD less than 90 days post-ablation, and second ablation. ER was defined as AF, atrial flutter (AFL), or atrial tachycardia (AT) > 30 seconds within BP. LR was defined as AF/AFL/AT > 30 seconds after BP.

Results
Of 478 patients, 14.9% were prescribed no AAD, 26.4% propafenone/flecainide, 34.5% sotalol/dofetilide, 10.7% dronedarone, and 13.6% amiodarone. Patients prescribed amiodarone were more likely to have persistent AF, hypertension, diabetes, and other comorbidities. In unadjusted analyses, there were no differences between groups in relation to ER (log rank P = 0.171), discontinuation of AAD before ninety days post-ablation (log rank P = 0.235), or freedom from second ablation (log rank P = 0.147). After multivariable adjustment, patients prescribed amiodarone or dronedarone were more likely to experience LR than those prescribed no AAD [Adjusted Hazard Ratio (AHR) 1.83, 95% CI 1.10–3.04, p = 0.02; AHR 1.79, 95% CI 1.05–3.05, p = 0.03, respectively].

Conclusion
Following first-time catheter ablation, there were no differences between specific AAD prescription and risk of ER, while those prescribed amiodarone or dronedarone in the BP were more likely to experience LR than those prescribed no AAD, which may represent an association due to confounding by indication.
Capacity building of healthcare workers: Key step towards elimination of viral hepatitis in developing countries
Authors: Rastogi Aayushi , Chauhan Sapna , Ramalingam Archana , Verma Madhavi , Babu Seena , Ahwal Sarita , Bansal Akanksha 
Published: June 2021

Background
Lack of awareness about viral hepatitis (VH) potentially predisposes the healthcare workers (HCWs) to a higher risk of infection and may in turn increase the risk of transmission of the infection to their families and in the community. Thus, combating VH, requires adequate and updated training to the HCWs. With this objective, Project PRAKASH designed a meticulously planned training program, aimed to assess the effect of a one-day training on VH among in-service nurses.

Methods and material
The content and schedule of scientific sessions of the training program were decided by subject experts to improve knowledge, attitude and practice(KAP) related to VH among in-service nurses. A 54-item questionnaire divided into four domains: Transmission and Risk Factors; Prevention; Treatment; Pathophysiology and Disease Progression were used to assess the KAP related to VH. The questionnaire consisted of four sections: demographic details, knowledge(30-items), attitude(12-items) and practice(12-itmes) with a total score of 30, 60 and 24 respectively in each section. The pre-post knowledge assessment was done and impact assessment survey was undertaken among the participants who completed six months post-training period. Paired-t-test was used to assess the effect of training on knowledge using SPSSv-22.

Results
A total of 5253 HCWs were trained through 32 one-day trainings, however data for 4474 HCWs was included in final pre-post knowledge analysis after removing the missing/incomplete data. Mean age of participants was 33.7±8.4 with median experience of 8(IQR: 3–13). Mean improvement in knowledge score was found to be significant (p<0.001) with mean knowledge score of 19.3±4.4 in pre-test and 25.7±3.9 in the post-test out of 30. Impact assessment survey suggested change in attitude and practice of HCWs.

Conclusion
The one-day training programs helped the in-service nurses to enhance their knowledge related to viral hepatitis. The study provided a roadmap to combating viral hepatitis through health education among HCWs about viral hepatitis.
Discontinuation of oral anticoagulation therapy after successful atrial fibrillation ablation: A systematic review and meta-analysis of prospective studies
Authors: Liu Xue-Hui , Xu Qiang , Luo Tao , Zhang Lei , Liu Hong-Jun 
Published: June 2021

Background
The safety of discontinuing oral anticoagulant (OAC) therapy after atrial fibrillation (AF) ablation remains controversial. A meta-analysis was performed to assess the safety and feasibility of discontinuing OAC therapy after successful AF ablation.

Methods
PubMed and Embase were searched up to October 2020 for prospective cohort studies that reported the risk of thromboembolism (TE) after successful AF ablation in off-OAC and on-OAC groups. The primary outcome was the incidence of TE events. The Mantel-Haenszel method with random-effects modeling was used to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs).

Results
A total of 11,148 patients (7,160 in the off-OAC group and 3,988 in the on-OAC group) from 10 studies were included to meta-analysis. No significant difference in TE between both groups was observed (OR, 0.73; 95%CI, 0.51–1.05; I2 = 0.0%). The risk of major bleeding in off-OAC group was significantly lower compared to the on-OAC group (OR, 0.18; 95%CI, 0.07–0.51; I2 = 51.7%).

Conclusions
Our study suggests that it may be safe to discontinue OAC therapy in patients after successful AF ablation. Additionally, an increased risk of major bleeding was observed in patients on OAC. However, the results of this meta-analysis should be interpreted with caution because of the heterogeneity among the included study designs. Large-scale and adequately powered randomized controlled trials are warranted to confirm these findings.