bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐Assembling Nanofibers Inhibit Inflammation in a Murine Model of Crohn's‐Disease‐Like Ileitis
Authors: Bury Matthew I. , Fuller Natalie J. , Clemons Tristan D. , Sturm Renea M. , Morrison Christopher D. , Lisy‐Snow Devon C. , Nolan Bonnie G. , Tarczynski Christopher , Ayello Emily M. T. , Boyce Amber , Muckian Bridget , Ahmad Nida , Hunter Catherine J. , Karver Mark R. , Stupp Samuel I. , Sharma Arun K. 
Published: February 2021

AbstractInflammatory bowel diseases are characterized by chronic inflammation, leading to the destruction of gastrointestinal tract tissue. Strategies specifically utilized to manage intestinal inflammation in patients afflicted with Crohn's disease (CD) are met with numerous obstacles. These include treatment‐specific physiological side effects and the development of resistance to biological and pharmacological therapies. As an alternative treatment approach, high aspect ratio supramolecular anti‐inflammatory peptide amphiphiles (AIF‐PAs) are engineered to mitigate small intestinal inflammation within the established, preclinical CD‐like ilieitis senescence accelerated mouse (SAMP1)/YitFcsJ murine model. Data derived from this study demonstrate ileitis that the direct injection of AIF‐PAs into inflammatory small intestinal skip lesions minimizes pathologic change in tissue architecture and intestinal physiology. When compared to untreated or saline injected control animals, AIF‐PAs substantially reduce lesion size and tissue‐specific inflammation, inciting cytokines tumor necrosis factor alpha (TNFα), interferon gamma (IFNγ), interleukin (IL)‐1β, and IL‐13 along with a concomitant decrease including in tissue proinflammatory innate and adaptive immune cells. Finally, this is accompanied by increased small bowel intestinal transit that aligns with improved gross intestinal pathology scoring. Taken together, this study provides evidence that AIF‐PAs may serve as a novel stand‐alone or combinatorial therapy to enhance efficacy in order to treat localized intestinal inflammation related to CD.
A Cyclodextrin‐Hosted Ir(III) Complex for Ratiometric Mapping of Tumor Hypoxia In Vivo
Authors: Xiao Peng , Liu Chunyan , Ma Tiancong , Lu Xiuhong , Jing Lihong , Hou Yi , Zhang Peisen , Huang Gang , Gao Mingyuan 
Published: February 2021

AbstractHypoxia is considered as a key microenvironmental feature of solid tumors. Luminescent transition metal complexes particularly those based on iridium and ruthenium have shown remarkable potentials for constructing sensitive oxygen‐sensing probes due to their unique oxygen quenching pathway. However, the low aqueous solubility of these complexes largely retards their sensing applications in biological media. Moreover, it remains difficult so far to use the existing complexes typically possessing only one luminescent domain to quantitatively detect the intratumoral hypoxia degree. Herein, an Ir(III) complex showing red emissions is designed and synthesized, and innovatively encapsulated within a hydrophobic pocket of Cyanine7‐modified cyclodextrin. The Ir(III) complex enables the oxygen detection, while the cyclodextrin is used not only for improving the water solubility and suppressing the luminescence quenching effect of the surrounding aqueous media, but also for carrying Cyanine7 to establish a ratiometric oxygen fluorescence probe. 2D nuclear magnetic resonance is carried out to confirm the host–guest structure. The oxygen‐responsive ability of the resulting ratiometric probe is evaluated through in vitro cell and multicellular experiments. Further animal studies about tumor oxygen level mapping demonstrate that the probe can be successfully used for quantitatively visualizing tumor hypoxia in vivo.
Seed yield, seed quality, profitability, and risk analysis among double crop soybean maturity groups and seeding rates
Authors: Rod Katherine S. , Shockley Jordan , Knott Carrie A. 
Published: February 2021

AbstractDouble crop soybean [Glycine max (L.) Merr.] production is common after soft red winter wheat (Triticum aestivum L.) harvest in the Upper Mid‐South and Ohio River Valley regions. However, optimal maturity group and seeding rate information is needed because most double crop soybean research is at least 45‐yr old. Relative maturity groups (rMG) 2.8, 3.5, 4.1, and 4.7, which ranged from a very short to an adapted long maturity group for the area, were evaluated at five seeding rates (123,600, 247,100, 370,700, 494,200, and 617,800 seeds ha−1) in a double crop soybean study at Princeton KY, from 2017 to 2019. The longest rMG (4.7) had the greatest seed yield and seeds m−2. However, rMG did not influence V2 and R8 plant population. The highest seeding rates of 494,200 and 617,800 seeds ha−1 had the greatest yield and seeds m−2 as well as the greatest V2 and R8 plant populations. Seeding rate did not affect protein or oil concentrations. Partial budget analysis determined that the combinations of rMG 4.1 at 494,200 seeds ha−1, rMG 4.7 at 494,200 seeds ha−1, and rMG 4.7 at 617,800 seeds ha−1 had similar economic net benefits as the University of Kentucky recommendation of rMG 4.7 at 370,000 seeds ha−1. However, the risk analysis predicted that rMG 4.7 at 494,200 seeds ha−1 would have the highest probability of a positive net return. These findings support the use of a longer rMG for the region as well as an increased seeding rate to maximize yield and economic net benefit.
Amyloid cranial polyneuropathy: A rare neurological presentation of immunoglobulin light‐chain amyloidosis
Authors: Agarwal Abhinav , Paul Wilson Benny , Kuruvilla Mathews Prasad , Viggeswarpu Surekha , Kango Gopal Gopinath 
Published: February 2021

AbstractAmyloidosis, a disease with extracellular tissue deposition of fibrils, results in clinical manifestations based on deposition of these fibrils in multiple organ systems. Usual manifestations include nephrotic‐range proteinuria, cardiac failure, hepatosplenomegaly, and skin manifestations. Common neurological manifestations include peripheral and autonomic neuropathies. Cranial neuropathy has been seldom reported and is an unusual clinical feature of amyloidosis. Here, we report an older man who presented with cranial nerve palsies along with other clinical features, including heart failure, proteinuria, weight loss, anorexia and distal symmetric polyneuropathy and was diagnosed with immunoglobulin light‐chain (AL) amyloidosis.
A novel heterotaxy gene: Expansion of the phenotype of TTC21B‐spectrum disease
Authors: Strong Alanna , Li Dong , Mentch Frank , Hakonarson Hakon 
Published: February 2021

AbstractTTC21B encodes the protein IFT139, a critical component of the retrograde transport system within the primary cilium. Biallelic, pathogenic TTC21B variants are associated with classic ciliopathy syndromes, including nephronophthisis, Jeune asphyxiating thoracic dystrophy, and Joubert Syndrome, with ciliopathy‐spectrum traits such as biliary dysgenesis, primary ciliary dyskinesia, and situs inversus, and also with focal segmental glomerulosclerosis. We report a 9‐year‐old male with focal segmental glomerulosclerosis requiring kidney transplant, primary ciliary dyskinesia, and biliary dysgenesis, found by research‐based exome sequencing to have biallelic pathogenic TTC21B variants. A sibling with isolated heterotaxy was found to harbor the same variants. This case highlights the phenotypic spectrum and unpredictable manifestations of TTC21B‐related disease, and also reports the first association between TTC21B and heterotaxy, nominating TTC21B as an important new heterotaxy gene.
Expansion of the ophthalmic phenotype of SPINT2‐related syndromic congenital sodium diarrhea
Authors: Ernst Julia , Hiasat Jamila , Alabek Michelle L. , Scanga Hannah L. , Motley William , Nischal Ken K. 
Published: February 2021

AbstractA 5‐year‐old girl presented with treatment‐refractory dry eye and recurrent episodes of eye pain. She had been previously diagnosed with syndromic congenital sodium diarrhea (SCSD) caused by a pathogenic variant in SPINT2. Her local pediatric ophthalmologist had made the diagnosis of severe dry eye with corneal erosions, based on which, we arranged an eye exam under anesthesia (EUA) and punctal plug placement. Anterior segment optical coherence tomography (OCT) and corneal photographs were taken during the procedure. There are reports describing similar ophthalmic findings in this syndrome. However, to the best of our knowledge, this is the first case report to document OCT imaging and corneal photographs in a patient with SCSD, which we feel expands the ophthalmic phenotype of this rare genetic disorder.
Effects of two dietary fiber levels on nutrient digestibility and intestinal fermentation products in captive brown howler monkeys (Alouatta guariba)
Authors: de Andrade Carneiro Lucas , Moreno Tatiane B. , Fernandes Barbara D. , Souza Camilla M. M. , Bastos Tais S. , Félix Ananda P. , da Rocha Chayane 
Published: February 2021

AbstractHerbivorous primates present a selective consumption profile and morphological adaptations to use the fibrous fraction of their diets. Brown howler monkeys (Alouatta guariba) are generalist herbivores; however, when kept under human care, they usually receive diets rich in fruits and with insufficient amounts of fiber. Thus, the objective of this study was to evaluate the effects of two levels of neutral detergent fiber (NDF) in howlers on apparent total tract digestibility coefficients (ATTDC), fecal consistency, and intestinal fermentation products. A group of 26 adult howler monkeys, 13 males and 13 females, were fed two diets formulated to have 33% or 40% NDF for 11 days, according to a randomized block design (N = 26). The block factor was the enclosures with one, two, or three individuals (each enclosure corresponded to an experimental unit), totaling in eight replicates per treatment. There were no differences in dry matter and nutrients intake between treatments (p > 0.05). The diet with 33% NDF resulted in higher (p < 0.05) ATTDC of crude protein and crude energy. However, lower fecal concentrations of short‐chain fatty acids (SCFA) and dry matter were observed in the treatment with 33% NDF in contrast to the 40% NDF group (p < 0.05). We recommend the inclusion of higher fiber levels (40% NDF) in the diet of howler monkeys since there is evidence of greater production of SCFA and improvement in fecal consistency.
Oncologic emergency in patients with skeletal metastasis of unknown primary
Authors: Torigoe Tomoaki , Imanishi Jungo , Yazawa Yasuo , Koyama Tadaaki , Kadono Yuho , Oda Hiromi , Saita Kazuo 
Published: February 2021

AimPatients with skeletal metastasis from prediagnosed primary malignancy sometimes have concurrent oncologic emergency (OE) during the first visit. This study aims to investigate the types of OEs and treatment outcome in such patients.MethodsWe have experienced 359 patients with skeletal metastasis from unknown primary malignancy. Among them, 130 patients required immediate admission for OE treatment (OE group), 229 patients had no OE and did not required immediate admission (non‐OE group).ResultsThe recognized types of OE were spinal cord compression in 60 patients, cancer pain in 30, hypercalcemia in 19, delirium in 16, deep vein thrombosis in 13, acute renal failure in 6, respiratory failure in 3, gastrointestinal hemorrhage in 3, and disseminated intravascular coagulation in 1. The overall 5‐year survival rates were 28% and 37% in the OE and non‐OE groups, respectively (P < 0.001). The multivariate analysis revealed that delirium (hazard ratio 4.2; 95% confidence interval, 1.6–12.5; P < 0.005) and respiratory failure (hazard ratio 22.6; 95% confidence interval, 4.5–92.8; P < 0.001) were significant prognostic factors in patients with OEs, whereas other OEs did not confer a significant risk for patient outcomes.ConclusionIn this study, OE was observed in as many as 36% of patients with skeletal metastasis from unknown primary malignancy. Delirium and respiratory failure were only two significant prognostic risk factors, which suggest that many of the OEs in untreated advanced cancer patients have probable chance to resolve. Early detection followed by appropriate treatment of such OEs is recommended.
Continuous discrete cubature quadrature Kalman filter
Authors:   Swati
Published: February 2021

AbstractIn this paper, cubature quadrature Kalman filter algorithm has been reformulated for nonlinear state space model of continuous‐discrete nature. The developed method is named as continuous‐discrete cubature quadrature Kalman filter (CD‐CQKF). The formulated algorithm has been applied to track the trajectory of an aircraft. The process is described with coordinated turn model. From the simulation result, it has been observed that the developed CD‐CQKF provides better estimation compared with continuous‐discrete cubature Kalman filter.
Precession of triaxially deformed neutron stars
Authors: Gao Yong , Shao Lijing 
Published: February 2021

AbstractA deformed neutron star (NS) will precess if the instantaneous spin axis and the angular momentum are not aligned. Such a precession can produce continuous gravitational waves (GWs) and modulate electromagnetic pulse signals of pulsars. In this contribution, we extend our previous work in a more convenient parameterization. We treat NSs as rigid triaxial bodies and give analytical solutions for angular velocities and Euler angles. We summarize the general GW waveforms from freely precessing triaxial NSs and use Taylor expansions to obtain waveforms with a small wobble angle. For pulsar signals, we adopt a simple cone model to study the timing residuals and pulse profile modulations. In reality, the electromagnetic torque acts on pulsars and affects the precession behavior. Thereof, as an additional extension to our previous work, we consider a vacuum torque and display an illustrative example for the residuals of body‐frame angular velocities. Detailed investigations concerning continuous GWs and modulated pulsar signals from forced precession of triaixal NSs will be given in future studies.
Green spectrofluorimetric determination of salmeterol xinafoate in its pure forms, medicinal commercial formula, and human plasma: Application for stability studies
Authors: Omar Mahmoud A. , Nagy Dalia M. , Ahmed Hoda S. , Attia Tamer Z. 
Published: February 2021

AbstractA natural, accurate, extremely rapid, and precise spectrofluorometric method has been developed and validated for determination of salmeterol (SAL) xinafoate in its medicinal commercial form and spiked human plasma. The native SAL fluorescence has been measured at 415 nm (after 340 nm as excitation) in distilled water. Different factors affecting the native fluorescence consistency of SAL were surveyed and optimized. The suggested procedure was capable of SAL determination over concentrations ranging 200–2000 ng.mL−1 with excellent correlation coefficient of 0.9995. The limits of detection and quantification were estimated as 44.44 ng mL−1 and 134.66 ng mL−1, respectively. The method has good accuracy and precision. The green spectrofluorometric method was used for determination of SAL in its commercial preparations and the results were in accordance with other reported methods regarding accuracy and precision. Moreover, the proposed procedure was enforced for stability indicating assay of SAL and for SAL determination in spiked human plasma. Nearly no cost, high sensitivity, and wide application make the proposed method ideally suited for analysis of SAL in quality control laboratories.
Being pro‐environmentally oriented SMEs: Understanding the entrepreneur's explicit and implicit power motives
Authors: Handrito Radityo Putro , Slabbinck Hendrik , Vanderstraeten Johanna 
Published: February 2021

AbstractThe increased number of environmental problems caused by business activities put higher pressures on entrepreneurs to implement pro‐environmental policies within their businesses. However, studies show that SMEs are less engaged with sustainable and pro‐environmental policies. Hence, it is important to understand the barriers and drivers of implementing a pro‐environmental strategy in SMEs from an entrepreneur's perspective. In a study with Indonesian SME owners, we find that environmental sustainability orientation (ESO) is driven by an entrepreneur's explicit and implicit power motives. Using polynomial regression with surface analysis, we also reveal that a high level of SME's ESO is affected by power motive discrepancy. We discuss implementations for policymakers, entrepreneurs, and educational programs in entrepreneurship.
Sustaining the sustainable development: How do firms turn government green subsidies into financial performance through green innovation?
Authors: Hu Die , Qiu Lu , She Maoyan , Wang Yu 
Published: February 2021

AbstractThe impact of government green subsidies on firms' green innovation behaviors and sustainable development has been recognized in the existing literature, but the deep relationship remains poorly understood. This study aims to examine the mechanism of how government green subsidies influence firms' financial performance via green innovation and how the mediating effect varies under different contingent conditions. Empirical results based on data of Chinese listed companies between 2006 and 2018 reveal that green subsidies have positive effects on green process and product innovation, but only green product innovation can rise higher financial performance, which further verifies that green subsidies positively influence financial performance through green product innovation rather than green process innovation. In addition, both higher absorptive capacity and higher market turbulence strengthen the indirect effect of green subsidies on firms' financial performance via green product innovation. Our study provides useful implications for enterprises by revealing the influence mechanism of green subsidies on financial performance through green innovation under different leveraging levels of internal and external conditions. It also provides basis for the government to formulate relevant environmental policies.
Influence of the change of methodology in the practical laboratories of the power electronics subject
Authors: Cabrera‐Peña Jose. M. , Quevedo Eduardo , Fabelo Himar , Ortega Samuel , Marrero‐Callicó Gustavo , Zapatera‐Llinares Alberto 
Published: February 2021

AbstractBackgroundThe use of novel didactic approaches in Science, Technology, Engineering, Arts and Mathematics (STEAM) academic programs is a relevant topic in current educational research. In this context, Project‐Based learning is shown as a promising didactic tool for improving the motivation of engineering students.ObjectiveTo propose an adapted project‐based approach for lecturing on Power Electronics. The main objective of the project‐based approach is to enhance the attention and motivation of the students in the practical lessons, increasing their knowledge about the subject and, hence, improving results in the theoretical part of the subject.MethodsFirst, we propose a project which combines all the theoretical aspects related to the subject Power Electronics, namely. “Power, Control, Monitoring and Supervision System of an Electric Motor.” Second, each subsystem of the final project is analyzed during each practical lesson, and simulation environments and real circuit manipulations are used for introducing complex Power Electronics concepts to undergraduate students.ResultsThis project‐based methodology has been compared with the demonstration method followed in the previous course by using the validated Students' Evaluations of Educational Quality survey (SEEQ).ConclusionsThe results show that the adopted methodology has clearly improved the SEEQ results with respect to the demonstration method.
Nutrition intervention is beneficial to the quality of life of patients with gastrointestinal cancer undergoing chemotherapy in Vietnam
Authors: Nguyen Linh Thuy , Dang Anh Kim , Duong Phuong Thi , Phan Hanh Bich Thi , Pham Chinh Tuyet Thi , Nguyen Anh Tuan Le , Le Huong Thi 
Published: February 2021

AbstractIntroductionThe best treatment therapy for gastrointestinal cancer patients is assessed by the improvement of health status and quality of life (QoL) after treatments. Malnutrition is related to loss of muscle strengths which leads to lower physical performance and emotional status. Thus, this study aimed to estimate the effects of nutritional interventions on the improvement of QoL among gastrointestinal patients undergoing chemotherapy in Vietnam.MethodsA quasi‐experiment with intervention and control groups for pre‐ and post‐intervention assessment was carried out at the Department of Oncology and Palliative Care—Hanoi Medical University Hospital from 2016 to 2019. Sixty gastrointestinal cancer patients were recruited in each group. The intervention regimen consisted of nutritional counseling, a specific menu with a recommended amount of energy, protein, and formula milk used within 2 months. Nutritional status and QoL of patients were evaluated using The Scored Patient‐Generated Subjective Global Assessment (PG‐SGA) and The European Organization for Research and Treatment of Cancer (EORTC). The difference in differences (DiD) method was utilized to estimate the outcome between control and intervention groups.ResultsAfter the intervention, patients of the intervention group had better changes in scores of global health status (Coef =16.68; 95% CI =7.90; 25.46), physical (Coef =14.51; 95% CI =5.34; 23.70), and role functioning (Coef =14.67; 95% CI =1.63; 27.70) compared to the control group. Regarding symptom scales, the level of fatigue, pain, and insomnia symptoms significantly reduced between pre‐ and post‐intervention in the intervention group. In addition, living in urban areas, defined as malnourished and having low prealbumin levels, were positively associated with the lower global health status/QoL score.ConclusionNutritional therapy with high protein was beneficial to the improvement in QoL, physical function and the reduction of negative symptoms among gastrointestinal cancer patients. Early individualized nutritional support in consultation with professional dietitians during chemotherapy plays an integral part in enhancing the QoL and better treatment prognosis.Clinical trial registration number: NCT04517708.