bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brazilian society of surgical oncology: Guidelines for the surgical treatment of mid‐low rectal cancer
Authors: Valadão Marcus , Cesar Daniel , Véo Carlos Augusto Rodrigues , Araújo Rodrigo Otávio , do Espirito Santo Gilmar Ferreira , Oliveira de Souza Rafael , Aguiar Samuel , Ribeiro Reitan , de Castro Ribeiro Héber Salvador , de Souza Fernandes Paulo Henrique , Oliveira Alexandre Ferreira 
Published: September 2021

AbstractBackgroundColorectal cancer (CRC) is the third leading cause of cancer in North America, Western Europe, and Brazil, and represents an important public health problem. It is estimated that approximately 30% of all the CRC cases correspond to tumors located in the rectum, requiring complex multidisciplinary treatment. In an effort to provide surgeons who treat rectal cancer with the most current information based on the best evidence in the literature, the Brazilian Society of Surgical Oncology (SBCO) has produced the present guidelines for rectal cancer treatment that is focused on the main topics related to daily clinical practice.ObjectivesThe SBCO developed the present guidelines to provide recommendations on the main topics related to the treatment of mid‐low rectal cancer based on current scientific evidence.MethodsBetween May and June 2021, 11 experts in CRC surgery met to develop the guidelines for the treatment of mid‐low rectal cancer. A total of 22 relevant topics were disseminated among the participants. The methodological quality of a final list with 221 sources was evaluated, all the evidence was examined and revised, and the treatment guideline was formulated by the 11‐expert committee. To reach a final consensus, all the topics were reviewed via a videoconference meeting that was attended by all 11 of the experts.ResultsThe prepared guidelines contained 22 topics considered to be highly relevant in the treatment of mid‐low rectal cancer, covering subjects related to the tests required for staging, surgical technique‐related aspects, recommended measures to reduce surgical complications, neoadjuvant strategies, and nonoperative treatments. In addition, a checklist was proposed to summarize the important information and offer an updated tool to assist surgeons who treat rectal cancer provide the best care to their patients.ConclusionThese guidelines summarize concisely the recommendations based on the most current scientific evidence on the most relevant aspects of the treatment of mid‐low rectal cancer and are a practical guide that can help surgeons who treat rectal cancer make the best therapeutic decision.
Cysteine‐rich intestinal protein 1 enhances the progression of hepatocellular carcinoma via Ras signaling
Authors: He Hong‐Yu , Hu Li 
Published: September 2021

AbstractThe present study aimed to explore the expression and clinical significance of cysteine‐rich intestinal protein 1 (CRIP1) mRNA in the serum of patients with hepatocellular carcinoma (HCC). Reverse transcription polymerase chain reaction (RT‐PCR) was performed to explore the level of CRIP1 mRNA in the tissues and serum of patients with HCC. Our data showed that the mRNA level of CRIP1 was significantly elevated in the serum and tissues of HCC patients. Moreover, serum CRIP1 mRNA was significantly elevated in HCC patients with larger tumor sizes and higher tumor node metastasis (TNM) stages. Receiver operating characteristic analysis showed that compared with a single marker, the combined detection of alpha‐fetoprotein, carcinoembryonic antigen, and CRIP1 had the highest accuracy, sensitivity, and specificity. Further study showed that the overexpression of CRIP1 enhanced the proliferation and migration of HepG2 cells, but the inhibition of CRIP1 decreased the proliferation and migration of HepG2 cells. Microarray assays and KyotoEncyclopedia of Genes and Genomes (KEGG) pathway analysis showed that overexpression of CRIP1 induced the activation of Ras signaling. Co‐immunoprecipitation (Co‐IP) assays indicated that CRIP1 could interact with Ras. To further evaluate whether CRIP1 interacts with Ras, a specific siRNA targeting Ras was selected. We found that Ras knockdown reduced the activation of Ras/AKT signaling even in HepG2 cells transfected with CRIP1. Moreover, elevated expression of CRIP1 increased the proliferation of HepG2 cells, but such effects could be abolished by silencing Ras. In summary, elevated CRIP1 levels enhanced the progression of CRIP1 via Ras signaling.
Hollow Microporous Organic Nanospheres with an Organocatalyst and a Metal Catalyst for Tandem Reactions
Authors: Zhang Li , Meng Guojie , Yu Haitao , Zhang Hui , Huang Kun 
Published: September 2021

AbstractAmino‐functionalized hollow microporous organic nanospheres supported palladium catalysts (Pd@NH2‐H‐MONs) are prepared via the integration of hyper‐crosslinking induced self‐assembly strategy and a simple impregnation method by employing polylactide‐b‐poly(Boc‐aminoethyl acrylamide)‐b‐polystyrene (PLA‐b‐PBOCa‐b‐PS) triblock copolymers as precursors, in which Pd nanoparticles are uniformly anchored on NH2‐H‐MONs based on the strong interaction between Pd nanoparticles and amino functional groups. Combining with the unique micro/mesoporous structure derived from hyper‐crosslinking shell and the degradation of PLA block, the coexistence of free amine moieties produced by the deprotection of PBOCa block and well‐dispersed Pd nanoparticles endows the Pd@NH2‐H‐MONs with excellent catalysis activity for various cascade reactions. The present strategy opens a novel avenue for the multifunctional H‐MONs acting as a superior candidate for the heterogeneous tandem catalysis reactions.
Catalyst Type Effects on Structure/Property Relations of Polypropylene Random Copolymers
Authors: Paulik Christian , Tranninger Cornelia , Wang Jingbo , Shutov Pavel , Mileva Daniela , Gahleitner Markus 
Published: September 2021

AbstractPolypropylene (PP) random copolymers are an important class of commercial materials that can be tuned for a wide range of different applications. The structure–property relations are mainly discussed in this article focusing on two major influencing factors, the catalyst system and the type and amount of comonomer. Ziegler–Natta (ZN) catalyst systems still dominate the production of polypropylene and todays sixth‐generation ZN catalysts are based on postphthalate donor systems. Metallocene (MC) catalysts offer possibilities to exactly control the microstructure of the polymer even better. Mostly, ethylene is used as comonomer being randomly distributed for up to 7.3 mol% when using ZN catalysts. For single site catalysts, homogenous (single phase) materials can be achieved up to ethylene contents of 20.8 mol%. The incorporated comonomer reduces the crystallization speed and the lamellar thickness of the polymer thus affording soft and highly transparent materials. Random copolymers and terpolymers with higherα‐olefins only play a minor role but offer an additional possibility for property adjustments. PP random copolymers can also be varied in their performance through multistage polymerizations, altering the comonomer content and or the molecular weight in the different polymerization reactors.
Contribution of uniparental disomy in a clinical trio exome cohort of 2675 patients
Authors: Wang Lei , Liu Pengfei , Bi Weimin , Sim Teresa , Wang Xia , Walkiewicz Magdalene , Leduc Magalie Sophie , Meng Linyan , Xia Fan , Eng Christine M. , Yang Yaping , Yuan Bo , Dai Hongzheng 
Published: September 2021

AbstractBackgroundUniparental disomy (UPD) is the inheritance of two homologous chromosomes from the same parent. UPD may result in clinical phenotypes when occurring on chromosomes with specific imprinting pattern, when leading to homozygosity of a deleterious recessive allele inherited from one carrier parent, or when associated with a mosaic aneuploidy. Due to the importance of UPD in genetic disease etiology, UPD analysis has started to be implemented in the context of exome sequencing (ES) or genome sequencing.MethodsWe developed an in‐house algorithm TRIPS (Trio Parentage/UPD Studies) to identify UPD events in trio ES cases. This method identifies regions with uniparental inheritance by utilizing the trio genotyping data obtained from the concurrent SNP array to delineate the parental origin of the SNPs in the proband.ResultsWe identified 16 UPD events from 2675 ES trios. Among those, four events led to imprinting disorders, seven unmasked a pathogenic/likely pathogenic variant in a recessive disease gene, and two were consistent with a mosaic genome wide paternal UPD pattern. Twelve of these UPD events directly contributed to the molecular diagnosis of the patients.ConclusionOur study demonstrated the contribution of UPD to the molecular diagnosis in one clinical ES cohort, thus UPD analysis should be incorporated into routine clinical ES interpretation.
The impact of exercise intended for fitness or sport on the prevalence of non‐specific neck pain in adults: A systematic review
Authors: Ireland Josh , Window Peter , O’Leary Shaun P. 
Published: September 2021

AbstractObjectiveThis study systematically reviewed the literature investigating the relationship between participation in exercise intended to improve fitness or sport and the prevalence of non‐specific neck pain in adults. A secondary objective evaluated if exercise characteristics (frequency, and total duration of weekly exercise) impacted any observed relationship between this form of exercise and neck pain prevalence.DesignNarrative systematic review.Literature SearchSix databases including Pubmed/Medline, Scopus, EMBASE, SPORTDiscus, CINAHL, and the Cochrane Library were searched from their inception up to April 2021.Study Selection CriteriaStudies were deemed eligible if they investigated the relationship between exercise participation and prevalence of non‐specific neck pain. Only full‐text, cross‐sectional and longitudinal studies in an adult population were included.Data SynthesisDue to heterogeneity of characteristics in the included studies, a meta‐analysis was not deemed feasible. Data were synthesised using narrative synthesis with subgroup analysis of exercise themes including frequency, and total weekly duration.ResultsFair to good quality evidence from eight studies indicated that regular participation in exercise intended for fitness or sport was associated with a reduced prevalence of neck pain in adults. Three cross‐sectional studies reported a positive relationship between greater weekly exercise duration and reduced neck pain prevalence.ConclusionThe results of this review provide preliminary evidence of a potential protective effect of participation in exercise intended for fitness or sport on the prevalence of non‐specific neck pain in the community. This protective relationship appeared to be stronger when exercise was undertaken for a greater total weekly duration.
History of bariatric surgery and COVID‐19 outcomes in patients with type 2 diabetes: Results from the CORONADO study
Authors: Blanchard Claire , Perennec Tanguy , Smati Sarra , Tramunt Blandine , Guyomarch Béatrice , Bigot‐Corbel Edith , Bordier Lyse , Borot Sophie , Bourron Olivier , Caussy Cyrielle , Coffin‐Boutreux Christine , Dutour Anne , Germain Natacha , Gonfroy‐Leymarie Céline , Meyer Laurent , Prevost Gaëtan , Roussel Ronan , Seret‐Bégué Dominique , Thivolet Charles , Vergès Bruno , Pichelin Matthieu , Gourdy Pierre , Hadjadj Samy , Wargny Matthieu , Pattou François , Cariou Bertrand ,   for the CORONADO investigators
Published: September 2021

AbstractObjectiveThis study assessed the impact of a history of metabolic and bariatric surgery (MBS) on the clinical outcomes in patients with type 2 diabetes (T2D) and severe obesity hospitalized for COVID‐19.MethodsIn this post hoc analysis from the nationwide observational CORONADO (Coronavirus SARS‐CoV2 and Diabetes Outcomes) study, patients with T2D and a history of MBS were matched with patients without MBS for age, sex, and BMI either at the time of MBS or on admission for COVID‐19. The composite primary outcome (CPO) combined invasive mechanical ventilation and/or death within 7 and 28 days following admission.ResultsOut of 2,398 CORONADO participants, 20 had a history of MBS. When matching for BMI at the time of MBS and after adjustment for diabetes duration, the CPO occurred less frequently within 7 days (3 vs. 17 events, OR: 0.15 [0.01 to 0.94], p = 0.03) and 28 days (3 vs. 19 events, OR: 0.11 [0.01 to 0.71], p = 0.02) in patients with MBS (n = 16) vs. controls (n = 44). There was no difference in CPO rate between patients with MBS and controls when matching for BMI on admission.ConclusionsThese data are reassuring regarding COVID‐19 prognosis in patients with diabetes and a history of MBS compared with those without MBS.
The nature of the exceptional impact of ultra‐low silica contents on the properties of cyanate ester resin‐based nano‐ and subnanocomposites
Authors: Bershtein Vladimir A. , Grigoryeva Olga P. , Yakushev Pavel N. , Fainleib Alexander M. 
Published: September 2021

AbstractOur study clarifies the nature of the exceptional impact of the ultra‐low content of silica (SiO2) units on the properties of the heterocyclic cyanate ester resin (CER) network matrix in the subnano‐ or nanocomposites. To this effect, we have performed a series of calculations of average distances between SiO2 units and the interfacial area values in the composites as functions of the content and size of SiO2 units. The estimates were made for the CER composites with SiO2 and POSS additives, based on these calculations and the composites' previously measured structural characteristics. It was found that the aforementioned unusual effect was controlled by the constrained interfacial matrix dynamics in the composites. Thus, when (a) the SiO2 content was 0.03–0.1 wt%, (b) SiO2 units and the matrix network had covalent bonding, and (c) SiO2 units had quasi‐regular distribution in the amorphous matrix (as found for the subnanocomposites), we found that distances between SiO2 units equaled 6 and 10 nm, that is, these distances were commensurable with the lengths of Kuhn segments in heterocyclic macromolecules.
Effect of curcumin on C‐reactive protein as a biomarker of systemic inflammation: An updated meta‐analysis of randomized controlled trials
Authors: Gorabi Armita Mahdavi , Abbasifard Mitra , Imani Danyal , Aslani Saeed , Razi Bahman , Alizadeh Shahab , Bagheri‐Hosseinabadi Zahra , Sathyapalan Thozhukat , Sahebkar Amirhossein 
Published: September 2021

It has been suggested that curcumin is a potential agent for lowering the levels of C‐reactive protein (CRP) and high‐sensitivity CRP (hs‐CRP), as markers of inflammation. In the current meta‐analysis, we attempted to clarify the efficacy of curcumin supplementation in lowering the concentrations of CRP and hs‐CRP in patients with autoinflammatory conditions. Nine studies were found evaluating the effect of curcumin on CRP levels, while 23 studies were identified for hs‐CRP. CRP concentration was decreased significantly compared to the placebo (WMD = ‐3.67 mg/L, 95% CI = −6.96 to −0.38, p = 0.02). There was a significant effect of curcumin at dose ≤1,000 mg/day on the CRP concentration. CRP concentration significantly decreased after >10‐week intervention compared with placebo.hs‐CRP concentration in the intervention group was significantly lower than that of placebo group. A significant effect of curcumin consumption was detected on the serum level of hs‐CRP in studies with prescribing ≤1,000 mg/day, and those with ≤10‐week duration of intervention. Curcumin consumption resulted in a reduction of hs‐CRP in a non‐linear fashion with stronger effects with less than 2000 mg curcumin per day. Curcumin seems to be beneficial in decreasing the hs‐CRP and CRP levels in proinflammatory settings.
Environmental management of waters and riparian areas to protect biodiversity through River Contracts: The experience of Tiber River (Rome, Italy)
Authors: Caneva Giulia , Ceschin Simona , Lucchese Fernando , Scalici Massimiliano , Battisti Corrado , Tufano Massimo , Tullio Maria Cristina , Cicinelli Emanuela 
Published: September 2021

AbstractUrban rivers may perform important ecological roles and provide many ecosystem services, especially in urban contexts. Considering this, River Contracts were officially introduced in 2000, during the Second Forum of the World Water Council, as participative agreements aimed at managing the complexity of fluvial ecosystems. Collecting data on fluvial and riparian biodiversity, establishing ecological relationships among biological components, and evaluating their resistance and resilience to anthropic impacts are needed to assess the ecological sustainability of the anthropic actions. Here, we provide a review of literature and regulation on River Contracts, and a methodological contribution to the evaluation of different environmental components, their ecological connections, and the role of anthropic impacts. To address the aim, we performed a critical analysis of the existing data on the Tiber River close to Rome. We used the information to identify the actions that should be included in the Tiber River Contract to improve its natural value and its potential ecosystem services. Several areas emerged where information was lacking such as the human impact on these ecosystems. Data highlight the disappearance of rare Mediterranean species and of those linked to wetland habitats, as well as an increase in alien species and species typical of disturbed areas. Further research on biodiversity and management is required to support nature conservation.
Organizational unlearning and inclusive innovation: The moderating role of green control ambidexterity
Authors: Zhao Yunhui , Wang Zhimin , Feng Taiwen , Kong Ting , Zhang Qiansong 
Published: September 2021

AbstractInclusive innovation is critical for poverty eradication and literature has identified several factors affecting inclusive innovation. However, our understanding of how organizational unlearning affects inclusive innovation is still limited. This study explores how organizational unlearning affects two dimensions of inclusive innovation (i.e., symbolic and substantive) via supply chain green learning and the moderating role of green control ambidexterity. We develop hypotheses based on organizational learning theory and organizational control theory and test hypotheses using survey data from 217 Chinese firms. The results indicate that supply chain green learning mediates the impacts of non‐environmental forgetting and environmental change on symbolic and substantive inclusive innovation. The results also reveal that the balanced dimension of green control ambidexterity strengthens the positive impact of supply chain green learning on substantive inclusive innovation, while the combined dimension of green control ambidexterity weakens the positive impact of supply chain green learning on symbolic inclusive innovation. This study enriches the literature and practice in the field of inclusive innovation and organizational control.
Nanoarchitectonics of Metal–Organic Frameworks for Capacitive Deionization via Controlled Pyrolyzed Approaches
Authors: Wang Hao , Chen Biaohua , Liu Di‐Jia , Xu Xingtao , Osmieri Luigi , Yamauchi Yusuke 
Published: September 2021

AbstractNext‐generation desalination technologies are needed to meet the increasing demand for clean water. Capacitive deionization (CDI) is a thermodynamically efficient technique to treat non‐potable water with relatively low salinity. The salt removal capacity and rate of CDI are highly dependent on the electrode materials, which are preferentially porous to store ions through electrosorption and/or redox reactions. Metal–organic frameworks (MOFs) with “infinite” combinations of transition metals and organic linkers simplify the production of carbonaceous materials often with redox‐active components after pyrolysis. MOFs‐derived materials show great tunability in both compositions and structures but require further refinement to improve CDI performance. This review article summarizes recent progress in derivatives of MOFs and MOF‐like materials used as CDI electrodes, focusing on the structural and compositional material considerations as well as the processing parameters and electrode architectures of the device. Furthermore, the challenges and opportunities associated with this research area are also discussed.
Dataset or Not? A Study on the Veracity of Semantic Markup for Dataset Pages
Authors: Alrashed Tarfah , Paparas Dimitris , Benjelloun Omar , Sheng Ying , Noy Natasha 
Published: September 2021

AbstractSemantic markup, such as , allows providers on the Web to describe content using a shared controlled vocabulary. This markup is invaluable in enabling a broad range of applications, from vertical search engines, to rich snippets in search results, to actions on emails, to many others. In this paper, we focus on semantic markup for datasets, specifically in the context of developing a vertical search engine for datasets on the Web, Google’s Dataset Search. Dataset Search relies on to identify pages that describe datasets. While was the core enabling technology for this vertical search, we also discovered that we need to address the following problem: pages from 61% of internet hosts that provide markup do not actually describe datasets. We analyze the veracity of dataset markup for Dataset Search’s Web-scale corpus and categorize pages where this markup is not reliable. We then propose a way to drastically increase the quality of the dataset metadata corpus by developing a deep neural-network classifier that identifies whether or not a page with markup is a dataset page. Our classifier achieves 96.7% recall at the 95% precision point. This level of precision enables Dataset Search to circumvent the noise in semantic markup and to use the metadata to provide high quality results to users.
Introduction
Authors: Kelly Ashley Scott , Lu Xiaoxuan 
Published: September 2021

AbstractThe book’s introduction, Landscape as Development, introduces the distinct positions of critic and planner in development and offers initial justifications for a “critical” practice of ecological planning, as construed by landscape architecture. Landscape architecture has the most substantial ecological mandate among its sister disciplines of architecture and urban planning and has made significant recent historical contributions to development planning, including being the origin of modern landscape ecology and geographic information systems science. In order to become “critical,” landscape architecture, as planning, must recognize the contradictions between urban or economic sustainability and the critical social theory undercurrents in sustainable development. We introduce a working definition of “critical landscape planning” as it is developed throughout the book: A practice of critical landscape planning, routed in landscape architecture, uses multiple forms of sustainability to plan for landscapes engaging in (or encountering) development. The critical landscape planner holds a cultural-technological position and simultaneously applies science to specific site conditions, is critical of that science, and in the process and practice of applying it, refines and deepens the relevant scope of work. This introduction finishes by covering the structure of this book.