bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Structural Neural Markers of MRI in Response to Mechanical Thrombectomy for Basilar Artery Occlusion
Authors: Liu Chang , Song Jia-Xin , Guo Zhang-Bao , Chen Lu-Ming , Zhao Chen-Hao , Zi Wen-Jie , Yang Qing-Wu 
Published: June 2021

Objective: Mechanical thrombectomy (MT) has been an effective first-line therapeutic strategy for ischemic stroke. With impairment characteristics separating it from anterior circulation stroke, we aimed to explore prognostic structural neural markers for basilar artery occlusion (BAO) after MT.Methods: Fifty-four BAO patients with multi-modal magnetic resonance imaging at admission from the multicenter real-world designed BASILAR research were enrolled in this study. Features including volumes for cortical structures and subcortical regions, locations and volumes of infarctions, and white matter hyperintensity (WMH) volumes were recorded from all individuals. The impact features were identified using ANCOVA and logistic analysis. Another cohort (n = 21) was further recruited to verify the prognostic roles of screened prognostic structures.Results: For the primary clinical outcome, decreased brainstem volume and total infarction volumes from mesencephalon and midbrain were significantly related to reduced 90-day modified Rankin score (mRS) after MT treatment. WMH volume, WMH grade, average cortex thickness, white matter volume, and gray matter volume did not exhibit a remarkable relationship with the prognosis of BAO. The increased left caudate volume was obviously associated with early symptomatic recovery after MT. The prognostic role of the ratio of pons and midbrain infarct volume in brainstem was further confirmed in another cohort with area under the curve (AUC) = 0.77.Conclusions: This study was the first to provide comprehensive structural markers for the prognostic evaluation of BAO. The fully automatic and semiautomatic segmentation approaches in our study supported that the proportion of mesencephalon and midbrain infarct volume in brainstem was a crucial prognostic structural neural marker for BAO.
Latamoxef for Neonates With Early-Onset Neonatal Sepsis: A Study Protocol for a Randomized Controlled Trial
Authors: Qi Hui , Wu Yue-E , Liu Ya-Li , Kou Chen , Wang Ze-Ming , Peng Xiao-Xia , Chen Liang , Cui Hong , Wang Ya-Juan , Li Jie-Qiong , Zhao Wei , Shen A-Dong 
Published: June 2021

Early-onset neonatal sepsis (EONS), a bacterial infection that occurs within 72 h after birth, is associated with high likelihood of neonatal mortality. Latamoxef, a semi-synthetic oxacephem antibiotic developed in 1980s, has been brought back into empirical EONS treatment in recent years. In the preliminary work, we established a population pharmacokinetics (PPK) model for latamoxef in Chinese neonates. Moreover, in order to better guide clinical treatment, we conducted dose simulation and found that ascending administration frequency could improve the target rate of 70% of patients having a free antimicrobial drug concentration exceeding the MIC during 70% of the dosing interval (70% fT &gt; MIC). Accordingly, this study is aimed to compare the 70% fT &gt; MIC, efficacy and safety between conventional regimen and PPK model regimen for rational use of latamoxef in EONS treatment. A single-blind, multicenter randomized controlled trial (RCT) for latamoxef will be conducted in Chinese EONS patients. Neonates (≤3 days of age, expected number = 114) admitted to the hospital with the diagnosis of EONS and fulfilling inclusion and exclusion criteria will be randomized (ratio of 1:1) to either a conventional regimen (30 mg/kg q12h) or model regimen (20 mg/kg q8h) latamoxef treatment group for at least 3 days. Primary outcome measure will be 70% fT &gt; MIC and secondary outcome indicators will be the latamoxef treatment failure, duration of antibiotic therapy, changes of white blood cell count (WBC), C-reactive protein (CRP) and procalcitonin (PCT), blood culture results during administration and incidence of adverse event (AE)s. Assessments will be made at baseline, initial stage of latamoxef treatment (18–72 h) and before the end of latamoxef treatment. Ethical approval of our clinical trial has been granted by the ethics committee of the Beijing Children’s Hospital (ID: 2020-13-1). Written informed consent will be obtained from the parents of the participants. This trial is registered in the Chinese Clinical Trial Registry (ChiCTR 2000040064).It is hoped that our study will provide a clinical basis for the rational clinical use of latamoxef in EONS treatment.
Relationship Between Critical Power and Different Lactate Threshold Markers in Recreational Cyclists
Authors: Valenzuela Pedro L. , Alejo Lidia B. , Montalvo-Pérez Almudena , Gil-Cabrera Jaime , Talavera Eduardo , Lucia Alejandro , Barranco-Gil David 
Published: June 2021

Purpose: To analyze the relationship between critical power (CP) and different lactate threshold (LT2) markers in cyclists.Methods: Seventeen male recreational cyclists [33 ± 5 years, peak power output (PO) = 4.5 ± 0.7 W/kg] were included in the study. The PO associated with four different fixed (onset of blood lactate accumulation) and individualized (Dmaxexp, Dmaxpol, and LTΔ1) LT2 markers was determined during a maximal incremental cycling test, and CP was calculated from three trials of 1-, 5-, and 20-min duration. The relationship and agreement between each LT2 marker and CP were then analyzed.Results: Strong correlations (r = 0.81–0.98 for all markers) and trivial-to-small non-significant differences (Hedges’ g = 0.01–0.17, bias = 1–9 W, and p &gt; 0.05) were found between all LT2 markers and CP with the exception of Dmaxexp, which showed the strongest correlation but was slightly higher than the CP (Hedges’ g = 0.43, bias = 20 W, and p &lt; 0.001). Wide limits of agreement (LoA) were, however, found for all LT2 markers compared with CP (from ±22 W for Dmaxexp to ±52 W for Dmaxpol), and unclear to most likely practically meaningful differences (PO differences between markers &gt;1%, albeit &lt;5%) were found between markers attending to magnitude-based inferences.Conclusion: LT2 markers show a strong association and overall trivial-to-small differences with CP. Nevertheless, given the wide LoA and the likelihood of potentially meaningful differences between these endurance-related markers, caution should be employed when using them interchangeably.
Internet Use and Problematic Use in Seniors: A Comparative Study in Switzerland and Poland
Authors: Rochat Lucien , Wilkosc-Debczynska Monika , Zajac-Lamparska Ludmila , Rothen Stéphane , Andryszak Paulina , Gaspoz Julie , Colombo Laura , Khazaal Yasser , Achab Sophia 
Published: June 2021

Background: Seniors have been only little considered in studies examining problematic internet use and associated health issues, although they may present risk factors that make them particularly vulnerable for the development of problematic internet use.Objectives: (1) To compare Internet use and problematic use among seniors in Switzerland and Poland; (2) To examine the relationships between problematic internet use, impulsivity traits and well-being as previous studies showed that internet can be used to cope with negative emotions or life dissatisfaction.Methods: A cross-sectional survey conducted between June 2016 and April 2017 with 264 older internet users aged above 60 years old recruited in Switzerland (88) and Poland (176) assessing sociodemographic variables, online activities, problematic internet use, impulsivity traits and well-being.Results: The two groups differed in their reported online activities in that Polish participants reported more searching for information and buying, whereas Swiss participants reported significantly greater problematic internet use than Polish participants. Finally, a multiple linear regression analysis performed on the whole sample indicated that lower well-being and being a Swiss participant were both significantly associated with greater problematic internet use, after age, gender, level of education, impulsivity traits have been controlled for.Discussion: Swiss seniors showed a more problematic internet use than Polish participants who focused more in their online activities on utility use of internet. The relationships between problematic internet use and well-being suggest that older adults use internet mainly to cope with negative emotion or life dissatisfaction. Socio-cultural differences that could account for these group differences as well as difference with young adults are discussed.
Emotional Reactivity and Family-Related Factors Associated With Self-Injurious Behavior in Adolescents Presenting to a Child and Adolescent Psychiatric Emergency Service
Authors: Kandsperger Stephanie , Jarvers Irina , Ecker Angelika , Schleicher Daniel , Madurkay Joseph , Otto Alexandra , Brunner Romuald 
Published: June 2021

Background: Adolescents presenting in a child and adolescent psychiatric emergency service show various psychiatric disturbances, most commonly suicidal ideation, suicide attempts, and non-suicidal self-injury (NSSI). It was postulated that especially disturbed emotion regulation contributes to self-injurious behavior of young people. This study aims to investigate the relevance of emotional reactivity (ER), as part of emotion regulation, during an acute crisis, how it relates to self-injurious behavior reinforcement and how a family as well as peers' history of self-injurious behavior are associated with self-injurious behavior of presenting adolescents. Additionally, crisis-triggering background factors were evaluated from the perspective of patients and their caregivers.Methods: A consecutive sample of 86 adolescents aged 11–18 years presenting to the emergency outpatient department due to self-injurious thoughts and behavior received a pretreatment psychiatric evaluation. Among other psychometric measures and structured clinical interviews, ER was measured via the Emotion Reactivity Scale (ERS). Family-related aspects were collected both through evaluation of history and through questionnaires filled in by custodians or parents.Results: Data analysis revealed that suicidal ideation was significantly related to family history with self-injurious behavior in comparison with a family background without such a history. A significant positive correlation was apparent between the ERS sensitivity score and occurrence of NSSI within the past year. A relationship between the ERS and distinct types of reinforcement as a motivation factor for NSSI was found. Post-hoc tests revealed a significant difference between boys and girls when no positive peers' history is present with boys having lower ERS scores than girls, but no difference when both groups had friends engaging in self-injurious behavior. There was only moderate agreement between parents and their children in naming reasons for the current crisis involving NSSI.Conclusion: Emotional regulation, especially ER, has an influence on patients' acute psychiatric symptomatology and when experiencing an acute crisis should be brought into focus early at psychiatric assessment. A history of self-injurious behavior taken from patient's family members and close circle of friends and agreement on reasons for the crisis should be routinely included in the exploration of a patient presenting with self-injurious behavior.
Public Continuum Beliefs for Different Levels of Depression Severity
Authors: Makowski Anna C. , Schomerus Georg , von dem Knesebeck Olaf 
Published: June 2021

Introduction: The notion that depression is a disorder that moves along a continuum is well-established. Similarly, the belief in the continuity of mental illness is considered an important element in the stigma process. Against this background, it is the aim of this study to examine whether public continuum beliefs vary with the severity of depressive symptoms.Methods: Analyses were based on computer-assisted telephone interviews (CATIs) conducted in winter 2019/2020 in Germany (N = 1,009, response rate 46.8%). Using three vignettes representing mild, moderate, and severe depressive symptoms, beliefs regarding the continuity of symptoms, specifically a fundamental difference, were assessed with seven items. Sociodemographic characteristics and own experiences with depression (affliction and contact) were introduced as covariates.Results: Significant differences between the three groups of severity were found for the majority of the items measuring continuum beliefs or perceived fundamental difference. However, only few items showed a linear trend indicating a parallel between symptom severity and beliefs. Multivariate regression models showed that a moderate degree of depression was positively associated with stronger continuum beliefs but also with greater perceived difference compared to the mild degree, while no significant associations emerged for the severe vignette.Limitations: Although a comparison of our sample with official statistics supports the external validity, we cannot rule out a selection bias. It is arguable in how far short case vignettes convey a holistic picture of a person affected by depressive symptoms.Conclusion: Our results do not indicate a parallel between symptom severity and public continuum beliefs.
Urban-Rural Disparities in Dental Services Utilization Among Adults in China's Megacities
Authors: Qi Xiang , Qu Xiaomin , Wu Bei 
Published: June 2021

Objective: China's dental care system is bifurcated between urban and rural areas. However, very few studies have examined the dental services utilization inequities in China's megacities, particularly in these urban and rural areas. This study aims to examine the urban-rural disparities in dental services utilization among adults living in China's megacities based on the Andersen dental services utilization model.Methods: This study used data from 4,049 residents aged 18–65 who participated in the “2019 New Era and Living Conditions in Megacities Survey.” Multivariate logistic regressions were employed to examine the associations between place of residence and dental services utilization for individuals from ten megacities in China. Predisposing variables (age, gender, marital status, living arrangement, and education), enabling variables (socioeconomic status, occupational status, income, insurance coverage, health attitude, and health behavior), and need variables (self-rated health, oral health status, gum bleeding) were controlled for.Results: The mean age of the 4,049 adults was 45.2 (standard deviation = 13.0), and 30.4% (n = 1,232) had no dental visits at all. Adults who resided in urban areas were more likely to use dental services [odds ratio (OR) = 1.57, 95% confidence interval (CI) = 1.30 to 1.91] than those residing in rural areas after controlling for key covariates. Factors associated with higher odds of visiting dentists include having a higher income (OR = 1.44, P &lt; 0.001), higher education level (OR = 1.53, P = 0.042), being covered by insurance for urban residents/employees (OR = 1.49, P = 0.031), having a positive attitude toward healthy diets (OR = 1.43, P &lt; 0.001), attending regular physical examination (OR = 1.66, P &lt; 0.001), having more tooth loss (OR = 1.05, P &lt; 0.001), and having frequent gum bleeding (OR = 2.29, P &lt; 0.001).Conclusion: The findings confirm that place of residence is associated with dental services utilization while adjusting for key covariates. Despite rapid economic development in China, many adults had never visited dentists at all. More efforts should be taken to encourage widespread dental care, such as providing more dental coverage and better access to dental care services.
Characterizing Spectral Channels of Visible Emission Line Coronagraph of Aditya-L1
Authors: Patel Ritesh , Megha A. , Shrivastav Arpit Kumar , Pant Vaibhav , Vishnu M. , Sankarasubramanian K. , Banerjee Dipankar 
Published: June 2021

Aditya-L1 is India’s first solar mission with the Visible Emission Line Coronagraph (VELC), which consists of three spectral channels taking high-resolution spectroscopic observations of the inner corona up to 1.5 Rʘ at 5,303, 7,892, and 10,747 Å. In this work, we present a strategy for the slit width optimization of the VELC using synthetic line profiles by taking into account the instrument characteristics and coronal conditions for log(T) varying from 6 to 6.5. The synthetic profiles are convolved with simulated instrumental scattered light and noise to estimate the signal-to-noise ratio (SNR), which will be crucial to designing the future observation plans. We find that the optimum slit width for VELC turns out to be 50 μm, providing sufficient SNR for observations in different solar conditions. We also analyzed the effect of plasma temperature on the SNR at different heights in the VELC field of view for the optimized slit width. We also studied the expected effect of the presence of a CME on the spectral channel observations. This analysis will help to plan the scientific observations of VELC in different solar conditions.
Characterization and Use of a Crop-Residue-Based Mat Mulch in the Production of Pepper (Capsicum annuum) during Dry Season
Authors: Hernández-Aranda Víctor , Rojas-Tortolero Diego , Álvarez-Barreto José , Arias-Vega Carlos , Proaño-Saraguro Jaime , Portalanza-Chavarria Alexandra , Sosa Daynet 
Published: June 2021

Agricultural mulches from plant waste constitute an ecological alternative due to their capacity to biodegrade and incorporate into the soil. This work aimed at evaluating, during a drought, the effects of a mat mulch, based on banana rachis and rice straw, on bell pepper (Capsicum annuum) production, and to characterize the material, both mechanically (traction resistance) and physical-chemically (water retention capacity, organic and inorganic components). Two contrasting irrigation regimes were used to determine the effect of the mat mulch on edaphic and productive parameters such as plant height, basal stem diameter, number of fruits and flowers, harvest, plant biomass, macro- and micronutrients in leaves, weeds/m2, and soil temperature. Treatments with the mat mulch resulted in increased height, number of fruits and flowers, biomass, and P, Zn and Cu concentrations. The mat mulch contributes to soil water retention, improves pepper agronomic variables response in plant’s height, basal stem diameter, and the number of flowers and fruits, especially with a low water irrigation regime. Furthermore, a 95% reduction in weed/m2, and soil temperature (18 °C) compared to air temperature (26.8 °C) was found. The characteristics of the waste-based mat mulch in soils offer new possibilities for environmentally friendly, efficient, and sustainable agricultural practices.
High Hydrostatic Pressure Treatment Ensures the Microbiological Safety of Human Milk Including Bacillus cereus and Preservation of Bioactive Proteins Including Lipase and Immuno-Proteins: A Narrative Review
Authors: Billeaud Claude 
Published: June 2021

Breast milk is the nutritional reference for the child and especially for the preterm infant. Breast milk is better than donated breast milk (DHM), but if breast milk is not available, DHM is distributed by the Human Milk Bank (HMB). Raw Human Milk is better than HMB milk, but it may contain dangerous germs, so it is usually milk pasteurized by a Holder treatment (62.5 °C 30 min). However, Holder does not destroy all germs, and in particular, in 7% to 14%, the spores of Bacillus cereus are found, and it also destroys the microbiota, lipase BSSL and immune proteins. Another technique, High-Temperature Short Time (HTST 72 °C, 5–15 s), has been tried, which is imperfect, does not destroy Bacillus cereus, but degrades the lipase and partially the immune proteins. Therefore, techniques that do not treat by temperature have been proposed. For more than 25 years, high hydrostatic pressure has been tried with pressures from 100 to 800 MPa. Pressures above 400 MPa can alter the immune proteins without destroying the Bacillus cereus. We propose a High Hydrostatic Pressure (HHP) with four pressure cycles ranging from 50–150 MPa to promote Bacillus cereus germination and a 350 MPa Pressure that destroys 106 Bacillus cereus and retains 80–100% of lipase, lysozyme, lactoferrin and 64% of IgAs. Other HHP techniques are being tested. We propose a literature review of these techniques.
FEBID 3D-Nanoprinting at Low Substrate Temperatures: Pushing the Speed While Keeping the Quality
Authors: Hinum-Wagner Jakob , Kuhness David , Kothleitner Gerald , Winkler Robert , Plank Harald 
Published: June 2021

High-fidelity 3D printing of nanoscale objects is an increasing relevant but challenging task. Among the few fabrication techniques, focused electron beam induced deposition (FEBID) has demonstrated its high potential due to its direct-write character, nanoscale capabilities in 3D space and a very high design flexibility. A limitation, however, is the low fabrication speed, which often restricts 3D-FEBID for the fabrication of single objects. In this study, we approach that challenge by reducing the substrate temperatures with a homemade Peltier stage and investigate the effects on Pt based 3D deposits in a temperature range of 5–30 °C. The findings reveal a volume growth rate boost up to a factor of 5.6, while the shape fidelity in 3D space is maintained. From a materials point of view, the internal nanogranular composition is practically unaffected down to 10 °C, followed by a slight grain size increase for even lower temperatures. The study is complemented by a comprehensive discussion about the growth mechanism for a more general picture. The combined findings demonstrate that FEBID on low substrate temperatures is not only much faster, but practically free of drawbacks during high fidelity 3D nanofabrication.
PENINGKATAN KUALITAS PEMBELAJARAN KULIAH LAPANGAN GEOLOGI PADA MAHASISWA GEOGRAFI FKIP UNDANA MELALUI LESSON STUDY
Authors: Hasan Muhammad Husain 
Published: June 2021

Geology is one of subject course in Geography Study which requires field studiy. Field studies that have been carried out so far are considered less effective because it has weaknesses from various aspects. The research method used was a descriptive survey. Data collection techniques by observation and interviews. The results showed that the geology topic field lecture activity at the first location was not optimal with a mean score of 80 pre-field observations, 60 on field activities, and 65 on activity reporting followed by learning reflections. Geological field course activities at the second location showed improvements where the results of the reflections at the first location were used to improve the quality at the second location so that observations were obtained with an average score of 80 in the pre-field, 77 in field activities, and 75 in activity reporting
EFEKTIVITAS MEDIA SOSIAL TERHADAP PENGETAHUAN REMAJA TENTANG NAPZA
Authors: Munadiah Wahyuddin  , Irfan Irfan , Aswar Aswar , Nurpadila Nurpadila 
Published: June 2021

Latar belakang : Penyalahgunaan NAPZA atau narkoba di kalangan remaja menjadi salah satu yang paling meresahkan di berbagai belahan dunia termasuk Indonesia. Penggunaan NAPZA memiliki dampak yang sangat membahayakan terhadap kesehatan baik fisik maupun mental serta di ikuti dengan gangguan interaksi sosial yang tidak di inginkan. Penyalahgunaan NAPZA jika tidak mendaptkan penanganan yang tepat dapat menjadi ancaman bagi kesejahteraan generasi yang akan datang karena semakin banyaknya remaja yang menggunakan NAPZA.
Tujuan : Penelitian ini bertujuan untuk mengetahui efektivitas penggunaan media sosial terhadap pengetahuan remaja tentang NAPZA.
Metode: Penelitian ini menggunakan metode observasional analitik dengan pendekatan Crossectional Study. Sampel penelitan sebanyak 45 orang remaja yang memenuhi criteria inklusi.
Hasil : hasil penelitian ini menunjukkan efek penggunaan media sosial terhadap pengetahuan remaja tentang NAPZA setelah dilakukan uji statistik Chi Square dengan nilai p=0.000 (α <0.05) Kesimpulan: penggunaan media sosial efektif dalam meningkatkan pengetahuan remaja tentang NAPZA