bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical impacts of copy number variations in B-cell differentiation and cell cycle control genes in pediatric B-cell acute lymphoblastic leukemia: a single centre experience
Authors: Crepinsek Klementina , Marinsek Gasper , Kavcic Marko , Prelog Tomaž , Kitanovski Lidija , Jazbec Janez , Debeljak Marusa 
Published: December 2021

Abstract

Background

IKZF1 gene deletions have been identified as a poor prognostic factor in pediatric B-cell acute lymphoblastic leukemia (B-ALL), especially in the presence of co-occurring deletions (IKZF1
plus profile). This study aimed to determine the frequency of IKZF1 deletions and deletions in other B-cell differentiation and cell cycle control genes, and their prognostic impact in Slovenian pediatric B-ALL patients.

Patients and methods
We studied a cohort of 99 patients diagnosed with B-ALL from January 2012 to December 2020 and treated according to the ALL IC-BFM 2009 protocol. Eighty-eight bone marrow or peripheral blood samples were analysed for copy number variations (CNVs) using the SALSA MLPA P335 ALL-IKZF1 probemix.

Results
At least one CNV was detected in more than 65% of analysed samples. The most frequently altered genes were PAX5 and CDKN2A/B (30.7%, 26.1%, and 25.0%, respectively). Deletions in IKZF1 were present in 18.2% of analysed samples and were associated with an inferior 5-year event-free survival (EFS; 54.8% vs. 85.9%, p = 0.016). The IKZF1
plus profile was identified in 12.5% of the analysed samples, and these patients had an inferior 5-year EFS than those with deletions in IKZF1 only and those without deletions (50.8% vs. 75.0% vs. 85.9%, respectively, p = 0.049). Overall survival (OS) was also worse in patients with the IKZF1
plus profile than those with deletions in IKZF1 only and those without deletions (5-year OS 76.2% vs. 100% vs. 93.0%, respectively). However, the difference between the groups was not statistically significant.

Conclusions
Our results are in concordance with the results obtained in larger cooperative clinical trials. Copy number variations analysis using the SALSA MLPA kit is a reliable tool for initial diagnostic approach in children with B-ALL, even in smaller institutions in low- and middle-income countries.
Lack of association between cortical amyloid deposition and glucose metabolism in early stage Alzheimer´s disease patients
Authors: Ehrlich Daniela , Dunzinger Andreas , Malsiner-Walli Gertraud , Grün Bettina , Topakian Raffi , Hodolic Marina , Kainz Elmar , Pichler Robert 
Published: December 2021

Abstract

Background
Beta amyloid (Aβ) causes synaptic dysfunction leading to neuronal death. It is still controversial if the magnitude of Aβ deposition correlates with the degree of cognitive impairment. Diagnostic imaging may lead to a better understanding the role of Aβ in development of cognitive deficits. The aim of the present study was to investigate if Aβ deposition in the corresponding brain region of early stage Alzheimer´s disease (AD) patients, directly correlates to neuronal dysfunction and cognitive impairment indicated by reduced glucose metabolism.

Patients and methods
In 30 patients with a clinical phenotype of AD and amyloid positive brain imaging, 2-[18F] fluoro-2-deoxy-d-glucose (FDG) PET/CT was performed. We extracted the average [18F] flutemetamol (Vizamyl) uptake for each of the 16 regions of interest in both hemispheres and computed the standardized uptake value ratio (SUVR) by dividing the Vimazyl intensities by the mean signal of positive and negative control regions. Data were analysed using the R environment for statistical computing and graphics.

Results
Any negative correlation between Aβ deposition and glucose metabolism in 32 dementia related and corresponding brain regions in AD patients was not found. None of the correlation coefficient values were statistically significant different from zero based on two-sided p- value.

Conclusions
Regional Aβ deposition did not correlate negatively with local glucose metabolism in early stage AD patients. Our findings support the role of Aβ as a valid biomarker, but does not permit to conclude that Aβ is a direct cause for an aberrant brain glucose metabolism and neuronal dysfunction.
Cervix-Online computer program: 27 years of hospital-based clinical registry for cervical cancer at the University Medical Centre Maribor
Authors: Lovrec Vida Gavric , Arko Darja , Takac Iztok 
Published: December 2021

Abstract

Background
Clinical registries are designed to collect quality data about the care for cancer patients in order to improve it. They gather data that are generated during diagnosis and cancer treatment and also post-treatment follow-up. Analysis of collected data allows an improvement in the quality of patient care and a comparison with other health care providers. The aim of the present article is to describe the current version and practice of hospital-based cervical cancer registry in UKC Maribor.

Materials and methods
The first questionnaire for monitoring patients with cervical cancer was introduced at the Department of Gynecologic and Breast Oncology of the Maribor General Hospital in 1994. Since then, the principles for treating cervical cancer have been revised on several occasions. Therefore, based on our experience and new approaches to treatment, we have frequently amended the questionnaire content. It was redesigned into a form that is currently in use and transformed into a Cervix-Online computer program in 2014.

Results
Over the last 27 years, we have collected data on cervical cancer patients treated at the University Medical Centre Maribor and former Maribor General Hospital. The Cervix-Online computer program that was developed for this purpose enabled a rapid and reliable collection, processing and analysis of 116 different data of patients with cervical cancer, including general data, history, diagnostic procedures, histopathological examination results, treatment methods, and post-treatment follow-ups.

Conclusions
The hospital-based cervical cancer registry with Cervix-Online computer program enables the collection of data to enhance diagnosis and the treatment of cervical cancer patients, the organization of day-to-day service, as well as the comparison of our treatment results with national and international standards. Incomplete or incorrect data entry, however, might pose a limitation of the clinical registry, which depends on several healthcare professionals involved in the diagnostic procedures, treatment, and follow-up of cervical cancer patients.
Educating to corporeity in DaD: the formative and expressive potential of the body in movement
Authors: Pallonetto Lucia , Palumbo Carmen 
Published: December 2021

Abstract
The present contribution aims to reflect on the fundamental importance of the promotion of corporeal education in educational contexts, in the light of adoption of distance teaching, due to the current and dramatic pandemic emergency. In rethinking and redesigning teaching, increasingly digitised, the fundamental question refers to the impossibility of thinking of a contemporary teaching that does not make use of technology and, at the same time, make use of a technology linked to the traditional principles of pedagogy and teaching.
Research was conducted on a sample of 78 children between the ages of 9 and 11, first through a bodily meaningful approach to promote the involvement of online students, resilience, motivation and then through the administration of the questionnaire Physical Activity Enjoyment Scale (Carraro, Young & Robazza, 2008), to confirm the role and importance of practice and pleasure in motor and sports activities. It is necessary to think of new models of teaching, mediated by technology and corporeity, which becomes a playful educational medium that allows education, logical and analytical thought to be able to best deploy its potential (MIUR, 2018).
The academic use of plagiarism software in Physical Therapy educational research: a case study
Authors: Panagiotis Gkrilias , Stefanos Armakolas , Irida Grigoropoulou , Anastasia Griva 
Published: December 2021

Abstract
Recently, cases of plagiarism in education have been on the rise with the underlying causes of their appearance being numerous. Due to the large extent of this phenomenon, specialised software has been developed and is available for users to check the presence or absence of plagiarism. The purpose of this paper is to study cases of plagiarism in education, as well as the available plagiarism software. Also, this case study presents a practical example of the implementation of the control process using plagiarism software, as well as its results, in an already published article. This case study points out the importance of performing a further quality control to those parts of the text where a textual coincidence was spotted by the plagiarism detection software.
Teaching digital skills to future teachers: a distance workshop experience
Authors: Falcinelli Floriana , Moscetti Caterina 
Published: December 2021

Abstract
In the school year 2020–2021, the Covid-19 pandemic imposed distance learning (in Italian, the DAD acronym is used). Therefore, the Degree Course in Primary Education Sciences of the University of Perugia has proposed an innovative programme for the training of future teachers by developing a distance learning laboratory focusing coding and computational thinking applied to teaching in kindergarten and primary school. During the educational technologies laboratory, held by Prof. Floriana Falcinelli, the students experimented coding both without computer (unplugged) and using the Scratch software. The programmed animations and video games were in direct connection with the Lifelong Kindergarten of the Massachusetts Institute of Technology (MIT) in Boston, where Scratch was created. The highly innovative aspects concerned both the proposed contents and the dimension of interaction and collaboration as entirely developed in online environments.
Variation in cone, seed, and kernel nutritional components traits of Pinus koraiensis
Authors: Hou Dan , Zhang Li , Wang Jinning , Li Jinquan , Zhao Changhai , Li Zhixin , Zhang Hanguo 
Published: December 2021

Abstract

Pinus koraiensis Sieb. et Zucc. (Korean pine) is an evergreen coniferous tree species with significant therapeutic and nutritional value in northeastern China. To assess variation and select highly productive and nutritionally valuable materials, 25 cone, seed, and kernel nutritional components traits were measured and analyzed. Coefficients of variation for phenotypic traits ranged from 6.32 % to 161.51 %, and the coefficients of most traits were approximately 10 %. Most traits showed significant or extremely significant differences among clones or groups, especially for amino acid content. Cone numbers were under moderate genetic control, and their repeated ability ranged from 0.42 to 0.53. Most other traits were under high genetic control, and their repeated ability was higher than 0.70. Despite the weak correlation with seed traits, cone number had strong correlations with other characters. Four principal components were obtained with a cumulative variance contribution of 93.51 %. The selected elite material will provide a theoretical basis for selection and breeding of P. koraiensis.
Swimming Attenuates Blood Pressure and Oxidative Stress in Hypertensive Rats
Authors: Petkovic Anica , Ravic Marko , Plecevic Sasa , Jeremic Jovana , Srejovic Ivan , Bolevich Sergey , Rankovic Goran , Turnic Tamara Nikolic , Jakovljevic Vladimir , Jeremic Nevena 
Published: December 2021

Abstract
Hypertension presents one of the main risk factors for cardiovascular diseases which are the leading cause of morbidity and mortality worldwide. Structural and mechanical changes of the heart and blood vessels as well as overproduction of reactive oxygen species may occur due to the increased blood pressure. Therewith, the goal of our study was to estimate the effects and duration of swimming as a possible therapy approach on blood pressure and oxidative stress parameters in normotensive and hypertensive rats. The study was conducted on 60 male Wistar albino rats divided into two groups, normotensive and hypertensive rats. Each of these groups was divided into three subgroups according to the swimming protocol. The swimming training was kept constant (60 min/day, for five days a week) with two days of rest. After six or nine weeks of the swimming protocol, blood pressure and oxidative stress markers were measured. The control group rats were put in water for one minute a day, in order to avoid water-induced stress. Training significantly reduced systolic blood pressure in hypertensive rats, while diastolic pressure did not change in the group that swam six or nine weeks. The results showed that swimming increases the activity of all measured antioxidative parameters, while values of prooxidants varied depending on the training protocol. Our results confirmed that swimming, as an aerobic exercise, decreases blood pressure and has time-dependent positive system adaptations, especially on the antioxidant parameters.
Проблемы систематизации международных избирательных стандартов
Authors: Любарев А. Е. 
Published: December 2021

Обсуждаются проблемы систематизации и классификации международных избирательных стандартов. Сравнивается классификация международных избирательных стандартов, предложенная в четырех документах («Свод рекомендуемых норм при проведении выборов» Европейской комиссии «За демократию через право»; отчет группы экспертов Бюро по демократическим институтам и правам человека ОБСЕ (БДИПЧ ОБСЕ) «Существующие обязательства по проведению демократических выборов в государствах – участниках ОБСЕ»; проект Европейской конвенции о стандартах выборов, избирательных прав и свобод; аналитический доклад Независимого института выборов «Российские выборы в контексте международных избирательных стандартов»). Обсуждаются также некоторые проблемы содержания международных избирательных стандартов, в частности проблема исключения из правил и декларативный характер многих стандартов.
Features of conducting an objective structured practical exam in the discipline “Technology of drug”
Authors: Yarema І. О. , Fedorovska М. І. , Grytsyk L. М. , Sinichenko А. V. 
Published: December 2021

The aim of the work: features elucidation of the objective structured practical exam (OSPE) on the discipline of “Technology of Drug”, conducting a survey among students to determine the main benefits of OSPE, as well as identifying difficulties that arose during the preparation and passing the exam.
Materials and methods: question papers, checklists for examiners and students, questionnaire, questionnaire results, analytical and statistical evaluation of the obtained data.
Results. The article presents OSPE features in the discipline “Technology of Drug”. The structure of the question paper by the stations 1, 2, 3 is considered, as well as checklists for examiners and students are presented. To determine the main advantages and disadvantages of the organization and conduction of OSPE, a survey was conducted among graduates of the Faculty of Pharmacy of Ivano-Frankivsk National Medical University.
Conclusions. According to the results of the survey, it was found that students noted the high level of organization and conduction of OSPE in the discipline of “Technology of Drug”. At the same time, the difficulties encountered during the preparation for and passing the exam were outlined, including the lack of time to prepare for the exam and the mixed form of education during the year due to the Covid-19 pandemic.
Key words: OSPE; technology of drugs; checklists; questionnaire; respondents.
Fundamental Aspects, Mechanical Behaviour and Mathematical Understanding of Friction Spot Stir Welds: A Review
Authors: Fattahi Arash , Supeni E.E. , Ariffïn M.K.A. , Ishak M.R. , Zolfaghari Sahar , Sharaf Hussein kadhim 
Published: December 2021

The energy-saving and environmental conservation are increasingly important issues in manufacturing and service industries worldwide that have received considerable attention in recent years. Most importantly, this process eliminates the grain solidification errors generated by the standard fusion process. Thus, in this papers types and methods of stir welding will be explained and discussed accordingly . Friction stir spot welding is a tunable method as it allows an effective control and amendment of processing parameters using refill and powder-assisted schemes that can solve the problem of the keyhole and mechanical weaknesses in the joining of light metals processed by conventional Friction stir spot welding. This comprehensive review mainly focuses on the fundamental aspects of Friction stir spot welding processes and their impacts on the microstructural features and mechanical performance and mathematical understanding of various similar and dissimilar systems. To conclude, the challenges in further modification of Friction stir spot welding and future outlooks in different engineering applications are presented.
Recognizing the better autograft and the factors influencing outcomes of revision anterior cruciate ligament reconstruction
Authors: Supreeth Sam , Al Ghanami Suwailim , Al Riyami Masoud , Al Habsi Ismail , Panchatcharam Sathiya M. , Abdelmasih Shenouda R. 
Published: December 2021

Objectives:
The outcome of revision anterior cruciate ligament reconstruction (ACLR) is inferior to that of the primary reconstruction and is influenced by multiple factors. The purpose of this study was to identify the better autograft suited for revision ACLR and to assess the factors influencing the outcome of revision.

Methods:
A total of 102 patients who underwent revision ACLR were enrolled in this study. The patients were grouped based on the type of autograft used for revision. The mechanism of injury and the cause of the primary ACLR failure, meniscal, and chondral status were noted. All patients’ Tegner Lysholm functional scores were assessed at 2 years of follow-up.

Results:
Almost 37.3% of the patients underwent revision ACLR with bone-patellar tendon bone, 41.3% with semitendinosus-gracilis, and 21.3% with quadriceps tendon autografts. The mean Tegner-Lysholm score was 85.4 ± 15.8, with the majority achieving good to excellent scores. Chondral defect of Grade 3/4 was associated with an inferior poorer functional outcome (P = 0.03). At a 2-year follow-up, the non-contact mechanism of primary ACLR failure was associated with worse scores compared to the contact mechanism of failure (P = 0.03). On comparison of Lysholm functional score between different autografts using the Kruskal-Wallis test, the p-value was insignificant (P = 0.9).

Conclusion:
Non-contact mechanism of primary ACLR failure and Grade 3/4 chondral defects was associated with a poorer functional outcome at 2 years post-revision ACLR. The overall functional outcome of revision ACLR was good to excellent in our Middle East Asian population, with no one autograft found to be superior to the other.
Direitos Indígenas no Baixo Tapajós, entre o Reconhecimento e a Negação
Authors: Tapajós Ib Sales 
Published: December 2021

Este trabalho trata da luta pela demarcação da Terra Indígena Maró, no Município de Santarém-Pará, e os obstáculos enfrentados pelos indígenas Borari e Arapium para alcança-la. Destaca-se neste sentido uma sentença de mérito da Justiça Federal em Santarém, proferida em novembro de 2014, que negou legitimidade Ã autoidentificação das comunidades do Maró como indígenas. O presente trabalho busca analisar criticamente os fundamentos da referida sentença, investigando se a tese acolhida pela Justiça Federal está em consonância com os direitos fundamentais assegurados aos povos indígenas nas normas jurídicas de direito interno e nas normas de direito internacional ratificadas pelo Estado brasileiro, especialmente a Convenção nº 169 da Organização Internacional do Trabalho.
relação entre a redução das ocupações de terra e as mudanças no confronto em torno da reforma agrária no Brasil
Authors: Araujo Ramon Torres 
Published: December 2021

Este trabalho tem como objetivo compreender a redução das ocupações de terra no Brasil. Na década de 1990, houve uma tendência Ã intensificação das ocupações, que alcançou seu ápice em 1999, quando foram realizadas 856 ações. Mas a partir de 2005 esta tendência se inverteu, atingindo a marca de 116 ocupações em 2010. Verificou-se que este fenômeno está relacionado a quatro condições sociais que expressam as mudanças no confronto em torno da reforma agrária: a mudança na orientação política da organização que mais empregou este repertório; a emergência de governos que não reconhecem a ocupação enquanto um repertório legítimo; a diminuição de um contingente de pessoas dispostas a se engajar nas ocupações; o arrefecimento do apoio de diversos atores relevantes Ã bandeira da reforma agrária.
“Vocês mataram o nosso rio!” Os Grandes Empreendimentos e a Produção da Morte do Rio São Francisco
Authors: Favero Celso Antonio 
Published: December 2021

O objetivo deste artigo é apresentar resultados de pesquisa realizada no trecho baiano da Bacia do Rio São Francisco, em ambas as margens, com a finalidade de identificar, caracterizar, hierarquizar e valorar danos com fortes impactos no equilíbrio ambiental da região. Esses danos são praticados por trinta empreendimentos econômicos vinculados a atividades como o agronegócio, a mineração, a produção de carvão vegetal, o represamento de águas (barragens) e a produção de energia elétrica (hídrica e eólica). A pesquisa foi realizada por uma equipe multidisciplinar compreendendo engenheiros, biólogos, cientistas sociais e economistas, com apoio de profissionais da área do direito. Os seus resultados foram apresentados em trinta relatórios, um para cada empreendimento, desdobrados, todos eles, em duas partes: na primeira, fez-se a identificação, a caracterização e a hierarquização das ações lesivas/ilícitas e dos danos ambientais; na segunda, com base em uma matriz (modelo matricial multicriterial), produziu-se a valoração desses danos e apresentou-se propostas para a restauração, na região, do equilíbrio ambiental violado. Neste artigo são apresentados os resultados da pesquisa contidos na primeira parte dos relatórios (identificação, caracterização e hierarquização das ações lesivas/ilícitas e dos danos ambientais), além de sua tipificação e de uma análise sócio/antropológica desses danos, principalmente na medida em que envolvem comunidades tradicionais da região.
Proposta de Emenda Ã Constituição (PEC) 215
Authors: Silva Liana Amin Lima da 
Published: December 2021

A Proposta de Emenda Ã Constituição (PEC 215/ 2000) é de autoria do Deputado Amir Morais Sá (PL/ RR) e tem como objetivo a transferência das responsabilidades do Poder Executivo na demarcação e titulação de terras indígenas e quilombolas para o Poder Legislativo. O direito originário dos povos indígenas sobre as terras que tradicionalmente ocupam está consagrado no artigo 231 da Constituição Federal brasileira. O artigo 68 do Ato das Disposições Constitucionais Transitórias (ADCT) reconhece expressamente os direitos das comunidades remanescentes dos quilombos Ã propriedade permanente das terras que ocupam. O processo legislativo da PEC 215 deve ser considerado eivado de vício porque desrespeita o direito Ã participação e Ã consulta prévia no que toca os atos legislativos que afetem os povos indígenas e comunidades tradicionais. A PEC 215 ameaça os direitos garantidos na Constituição, representando um retrocesso nas normas constitucionais que tratam de direitos fundamentais, o que é inadmissível em termos de cláusulas pétreas.