bluuebunny/crossref_metadata_2025_split huggingface dataset:
KEMAMPUAN KEPEMILIKAN INSTITUSIONAL MEMODERASI PENGARUH EARNING POWER, LEVERAGE, DAN UKURAN PERUSAHAAN TERHADAP MANAJEMEN LABA
Authors: Raka Raka , Suhartono Sugi 
Published: May 2021

This study aims to determine whether earnings power, leverage, and firm size affect earnings management and whether institutional ownership moderate the effect of earning power, leverage, and size of the company on earnings management. The theory underlying this research is agency theory and positive accounting theory. Based on both theories, the conflict of interest that occurs between the owner and the manager where each will tend to emphasize personal interests or certain parties. The sample in this study consists of 93 manufacturing companies listed on the Indonesia Stock Exchange for the period 2014-2016. Sampling was done by purposive sampling method. The data analysis technique used to test the hypothesis is Moderated Regression Analysis. The results of this study indicate earnings power, leverage, and firm size have a positive effect on earnings management. Institutional ownership weakens the effect of earning power on earnings management.

Keywords : Earning management, earning power, leverage, company size
Influencia de las variaciones climáticas en la producción de sacha inchi (Plukenetia volubilis L.)
Authors: Núñez-Rodríguez José de Jesús , Carvajal-Rodríguez Julio César , Ramírez-Novoa Luisa Lorena 
Published: June 2021

La producción de sacha inchi (Plukenetia volubilis L.) en los países tropicales de América del Sur ha experimentado un rápido aumento por la alta calidad y aportes nutricionales del aceite en sus componentes Omegas 3, 6 y 9. Su potencial para el desarrollo de nuevos emprendimientos está llevando a numerosos agricultores a convertirse en sachicultores, reemplazando cultivos tradicionales y, en otros casos, siendo una alternativa para la sustitución de cultivos ilícitos. Al revisar la literatura disponible sobre sacha inchi se evidencia que la mayor cantidad de investigaciones realizadas sobre esta especie promisoria ha estado enfocada en el aceite y sus derivados, con una escasa atención sobre los procesos agronómicos, en los cuales se aplican modelos de transferencia tecnológica predeterminados y no adaptados a las condiciones medioambientales, culturales y económicas particulares de las zonas de producción. En este artículo se presenta una revisión de artículos e informes técnicos publicados en Google Académico y Scopus relacionados con la influencia de las variaciones climáticas en la producción de sacha inchi, abarcando las fases de germinación, crecimiento, floración y reproducción, presencia de plagas y enfermedades, cosecha, postcosecha y extracción del aceite. Se pretende poner a disposición de los lectores una mirada actualizada de las implicaciones que los aumentos o disminuciones de las temperaturas y precipitaciones tienen sobre el cultivo de sacha inchi, las cuales constituyen áreas de conocimiento poco exploradas en esta especie oleaginosa promisoria.
OSCILLATION THEORY FOR A CLASS OF SECOND ORDER QUASILINEAR DIFFERENCE EQUATIONS
Authors: THANDAPANI E. , ARUL R. 
Published: May 2021

In this paper the authors establish necessary and sufficient conditons for the second order quasilinear difference equation
\[\Delta (\alpha_n(\Delta y_n)^{\alpha*})+f(n, y_{n+1})=0\qquad\qquad n\in N(n_0)\qquad\qquad \text{(E)}\]

to have various types of nonoscillatory solutions. In addition, in the case when (E) is either strongly superlinear or strongly sublinear, they establish necessary and su伍 c1ent conditions for all solutions to oscillate.
Implantação de sistema de IOT para rastreamento de máquinas de terraplanagem a serviço de uma indústria de celulose
Authors: Sousa Barbara Martins de , Longhini Tatielle Menolli 
Published: June 2021

A telemetria satelital tem sido utilizada como uma alternativa para obter diferentes informações, em tempo real, de equipamentos, elevando a produtividade dos processos. Este trabalho visa implantar de sistema de IoT para rastreamento em máquinas de terraplanagem a serviço de uma indústria de celulose, demonstrando os impactos de tal tecnologia. Para isso, buscou-se substituir formulário manual de controle de uso de máquinas por desenvolvimento de sistema de telemetria satelital, que permitiam o acompanhamento em tempo real dos equipamentos usados. Obteve-se êxito na implementação do sistemas e alcançou-se ganho de produtividade de 1,0% na motoniveladora, 0,33% na pá carregadeira e 0,81% na retroescavadeira, comprojeção de redução de custo de 0,8% da hora-máquina – resultado replicável às outras classes de máquinas de terraplanagem. Em termos teóricos, reforçou-se a importânca do uso de sistema de IoT, uma vez que possibilita controle operacional à distância, monitoramento de indicadores-chave em tempo real, levantamento de não conformidades, facilidade de armazenamento de dados e diminuição de documentos físicos e requisitou mudanças organizacionais e culturais entre os colaboradores. Trata-se de um sistema facilmente replicável a empresas com tais tipos de operação.
Telemedicina
Authors: Lovo Javier 
Published: May 2021

la telemedicina encarna la unión entre tecnología y medicina puestas al servicio de la persona. El avance de las nuevas herramientas para la información y comunicación han tenido su impacto en todas las áreas de la medicina. Particularmente en la medicina de familia, abre múltiples oportunidades en áreas como: teleconsulta, telemonitoreo de enfermedades crónicas, teleatención de problemas cutáneos, teleatención al niño, teleatención en embarazo y puerperio, teleatención mental, teleprevención, telerehabilitación, así como posibilidades en formación, referencia, interconsulta y atención domiciliar. La telemedicina no puede ser un sustituto, sino un poderoso acompañante de la atención médica, que permita brindar los servicios integrales que la especialidad ofrece a su población.
Associação entre a abordagem médica centrada na pessoa e a satisfação com a consulta em atenção primária à saúde
Authors: Castro Rodrigo Caprio Leite de , Knauth Daniela Riva 
Published: May 2021

Introdução: A aplicação do método clínico centrado na pessoa (MCCP) busca alcançar a compreensão da pessoa e da sua doença por meio da abordagem de duas perspectivas: a do médico e a da pessoa. A satisfação dos usuários é considerada um importante indicador de avaliação dos serviços. Objetivo: O presente artigo tem como objetivo investigar se há associação entre o grau de orientação ao MCCP, segundo a percepção da pessoa, e a satisfação com a última consulta médica em um serviço de atenção primária à saúde (APS). Metodologia: Trata-se de estudo transversal, realizado com pessoas com hipertensão e/ou diabetes nas 12 unidades de um serviço de APS, em Porto Alegre, RS (n = 408). O grau de orientação ao MCCP foi medido pelo instrumento “Percepção do Paciente sobre o Centramento da Consulta” (PPCC). Resultados: O baixo escore geral do PPCC (o que corresponde à alta orientação ao MCCP) esteve associado significativamente com a maior satisfação das pessoas com aspectos relacionados ao serviço (forma de agendamento e cordialidade da recepção) e ao atendimento médico (atenção dada às queixas pelo médico, exame físico do médico, explicações sobre problema e explicações sobre prognóstico), com a consulta em geral e com o tratamento da hipertensão arterial sistêmica e/ou do diabetes mellitus na unidade de saúde. Discussão: O médico de APS deve ser mais orientado à pessoa para que possa atingir, portanto, níveis mais altos de satisfação. Nessa perspectiva, a incorporação da satisfação dos usuários na avaliação dos serviços de saúde deve se constituir em indicador de qualidade, sobretudo, da abordagem praticada pelo médico.
Evaluation of Bacterial Species in Patients with Skin Infection and their Antibiogram
Authors: Nwankwo Immaculata U. , Edward Kelechi C. , Nwoba Chinedu N. , Okwudiri Chinyere V. 
Published: June 2021

Introduction: The skin is a barrier that limits invasion and growth of pathogenic bacteria. Bacterial species in patients with skin infection and their antibiogram were evaluated for the presence of inhabiting bacteria.
Method: The sample obtained with swab sticks were streaked on their respective culture plates containing nutrient agar, MacConkey agar and blood agar, incubated 370 for 24h. The recovered bacteria after incubation were characterized and identified according to standard microbiological criteria.
Results: Five bacteria species were isolated which includes Staphylococus aureus; Escherichia coli, Klebsiella specie, Proteus sp and Pseudomonas aeruginosa. Staphylococus aureus (33.03%) had the highest percentage occurrence while Proteus Sp (9.17%) had the lowest percentage occurrence. The highest number of isolates were recovered from male patients (61.47%). Age wise the least percentage of isolates were gotten from age group 31-40 (1.83%) while the highest was obtained from those within the age range of 11-20 (40.37%) followed by 1-10 years of age (25.69%). More isolates were recovered from in-patients (68.81%) than from Out-patients (31.19%). The antibiotic sensitivity test showed that Klebsiella sp, Proteus spp and Staphylococcus aureus were sensitivity to all the antibiotics tested while pseudomonas aeruginosa had 30% activity (sensitivity to only 3 drugs) for the antibiotics used in this study.
Conclusion: From this study, it can be said that Staphylococcus aureus, Escherichia coli, Klebsiella sp, Proteus sp and Pseudomonas aeruginosa are implicated in the skin infections in humans and their presence if not treated will lead to long term disease in human affected.
A radical change in our autism research strategy is needed: Back to prototypes
Authors: Mottron Laurent 
Published: June 2021

AbstractThe evolution of autism diagnosis, from its discovery to its current delineation using standardized instruments, has been paralleled by a steady increase in its prevalence and heterogeneity. In clinical settings, the diagnosis of autism is now too vague to specify the type of support required by the concerned individuals. In research, the inclusion of individuals categorically defined by over‐inclusive, polythetic criteria in autism cohorts results in a population whose heterogeneity runs contrary to the advancement of scientific progress. Investigating individuals sharing only a trivial resemblance produces a large‐scale type‐2 error (not finding differences between autistic and dominant population) rather than detecting mechanistic differences to explain their phenotypic divergences. The dimensional approach of autism proposed to cure the disease of its categorical diagnosis is plagued by the arbitrariness of the dimensions under study. Here, we argue that an emphasis on the reliability rather than specificity of diagnostic criteria and the misuse of diagnostic instruments, which ignore the recognition of a prototype, leads to confound autism with the entire range of neurodevelopmental conditions and personality variants. We propose centering research on cohorts in which individuals are selected based on their expert judged prototypicality to advance the theoretical and practical pervasive issues pertaining to autism diagnostic thresholds. Reversing the current research strategy by giving more weight to specificity than reliability should increase our ability to discover the mechanisms of autism.Lay SummaryScientific research into the causes of autism and its mechanisms is carried out on large cohorts of people who are less and less different from the general population. This historical trend may explain the poor harvest of results obtained. Services and intervention are provided according to a diagnosis that now encompasses extremely different individuals. Last, we accept as a biological reality the constant increase over the years in the proportion of autistic people among the general population. These drifts are made possible by the attribution of a diagnosis of autism to people who meet vague criteria, rather than to people who experienced clinicians recognize as autistic. We propose to change our research strategy by focusing on the study of the latter, fewer in number, but more representative of the “prototype” of autism. To do this, it is necessary to clearly distinguish the population on which the research is carried out from that to which we provide support. People must receive services according to their needs, and not according to the clarity of their diagnosis.
Lipase immobilization on biodegradable film with sericin
Authors: de Castro Michael da Conceição , Garcia Patrícia Salomão , Andrade Milena Martins , Grossmann Maria Victória Eiras , Simões Bruno Matheus , Samulewski Rafael Block , Baron Alessandra Machado 
Published: May 2021

AbstractAn ecofriendly and low‐cost film composed by cassava starch, polyvinyl alcohol, and sericin blend (CS–PVA–SS) was synthesized, characterized, and applied as a novel support for Botryosphaeria ribis EC‐01 lipase immobilization by enzyme–film–enzyme adsorption. Film revealed thickness between 230 and 309 μm and higher flexibility and malleability in comparison with film without SS. Based on p‐nitrophenyl palmitate hydrolysis reaction, the activity retention of immobilized lipase was 987%. For optimal conditions, the yield in ethyl oleate was 95% for immobilized enzyme. Maximum yield was obtained at 49°C, molar ratio oleic acid:ethanol of 1:3, 1.25 g lipase film or 50 U (1.03 ± 0.03 mg protein) and 30 h. Even after seven cycles of use, immobilized lipase showed 52% reduction in ester yield. Biodegradable and biorenewable film is a promising material as a support to immobilize lipases and application in biocatalysis.
Production and stability of pigments by Talaromyces purpurogenus LC128689 in an alternating air phase–liquid phase cultivation system
Authors: Ugwu Cosmas T. , Ogbonna Christiana N. , Ogbonna James C. , Aoyagi Hideki 
Published: May 2021

AbstractEffects of carbon source, nitrogen source, and alternatingly submerging the cells and exposing to gaseous oxygen on pigment production by Talaromyces purpurogenus LC128689, as well as pH, temperature, and UV stability of the pigments were investigated. Although fructose supported higher cell growth, a mixture of glucose and glycerol resulted in higher pigment production. Out of the organic and inorganic nitrogen sources investigated, peptone gave the highest cell concentration (7.2 ± 1.1 g/L) and pigment production (p ≤ 0 .05). The cells were then immobilized in loofa sponge and cultivated under alternating liquid phase–air phase (ALAP) system whereby the cells were alternatingly submerged and exposed to gaseous oxygen. After 20 days of cultivation, the concentrations of the red, orange, and yellow pigments were 30.15 AU500 nm, 15 AU460 nm, and 6.25 AU400 nm, respectively. In comparison with submerged culture in flasks, the red and orange pigments were 100% and 50% higher (p ≤ 0.05) in ALAP system. On the other hand, the yellow pigment was 100% higher in flask cultures than in ALAP. The three pigments were stable within a pH range of 2–12, retained more than 80% of their color intensity after autoclaving at (121°C and 1.0 atm) for 15 min and exposure to UV (3 uW/cm2) for 24 h.
Stable overexpression of mutated PTEN in Chinese hamster ovary cells enhances their performance and therapeutic antibody production
Authors: Zhou Qin , Zhang Yujie , Lu Xiaoxiang , Wang Chang , Pei Xinxin , Lu Yafang , Cao Cheng , Xu Changzhi , Zhang Buchang 
Published: May 2021

AbstractChinese hamster ovary (CHO) cells with a high viable cell density (VCD), resilience to culture stress, and the capacity to continuously express recombinant proteins are highly desirable. Phosphatase and tension homology deleted on chromosome ten (PTEN) functions as a key negative regulator of the PI3K/Akt signaling pathway, mediating cell growth and survival. Its oncogenic mutant endows cells with an enhanced proliferation rate and resistance to death. In this study, the role of oncogenic PTEN C124S or G129E on the performance of CHO‐K1 and CHO‐IgG cells was investigated. Our results showed that CHO‐K1 cells stably expressing PTEN C124S or G129E exhibited enhanced proliferation, reduced apoptosis rate, and increased transient expression of therapeutic antibodies compared to the control cells. Moreover, the stable overexpression of PTEN C124S or G129E endowed CHO‐IgG cells with higher cell viability, VCD, and antibody titers (yield increased by approximately 0.77‐fold) in the fed‐batch culture process and enhanced their performance in response to the addition of sodium lactate. Moreover, the engineering of mutated PTEN in CHO‐IgG cells did not alter antibody quality. Collectively, our data suggest that mutated PTEN is a potential target for improving the manufacture of therapeutic antibodies.
An improved lentiviral system for efficient expression and purification of β‐defensins in mammalian cells
Authors: Ahmed Shiraz , Tao Jiang , Wang Miaochen , Zhai Yue , Liu Wenhai , Jayachandran Muthukumaran , Chu Chen , Qu Shen , Zhang Jin , Zhang Yonglian , Fei Zhaoliang 
Published: May 2021

Abstractβ‐Defensins are a family of conserved small cationic antimicrobial peptides with different significant biological functions. The majority of mammalian β‐defensins are expressed in epididymis, and many of them are predicted to have post‐translational modifications. However, only a few of its members have been well studied due to the limitations of expressing and purifying bioactive proteins with correct post‐translational modifications efficiently. Here we developed a novel Fc tagged lentiviral system and Fc tagged prokaryotic expression systems provided new options for β‐defensins expression and purification. The novel lentiviral system contains a secretive signal peptide, an N‐terminal IgG Fc tag, a green fluorescent protein (GFP), and a puromycin selection marker to facilitate efficient expression and fast purification of β‐defensins by protein A magnetic or agarose beads. It also enables stable and large‐scale expression of β‐defensins with regular biological activities and post‐translational modification. Purified β‐defensins such as Bin1b and a novel human β‐defensin hBD129 showed antimicrobial activity, immuno‐regulatory activity, and expected post‐translational phosphorylation, which were not found in Escherichia coli (E. coli) in expressed form. Furthermore, we successfully applied the novel system to identify mBin1b interacting proteins, explaining Bin1b in a better way. These results suggest that the novel lentiviral system is a powerful approach to produce correct post‐translational processed β‐defensins with bioactivities and is useful to identify their interacting proteins. This study has laid the foundation for future studies to characterize function and mechanism of novel β‐defensins.
Efficacy of combination therapy of steroid and methotrexate for refractory pemphigus
Authors: Kanaoka Miwa , Matsukura Setsuko , Okawa Tomoko , Nakamura Kazuko , Takahashi Kazuo , Aihara Michiko 
Published: May 2021

AbstractThe first line of treatment for pemphigus is systemic corticosteroids. When steroids alone do not result in remission, additional immunosuppressants are recommended. Twenty‐two patients with pemphigus vulugris were treated with steroids and other immunomodulators. However, they were refractory, and hence, methotrexate (MTX) was administered. The efficacy of MTX was assessed for 16 patients who were able to continue MTX therapy for 1 year. Steroid dose reduction was possible in 11 patients. One patient with severe infections had diabetes and was elderly. Our results suggested that MTX was useful as a steroid‐sparing agent in treating recalcitrant pemphigus, when an initial immunosuppressant treatment had failed. However, adverse effects should be closely monitored.
Influences of adversity across the lifespan on respiratory sinus arrhythmia during pregnancy
Authors: Kaliush Parisa R. , Terrell Sarah , Vlisides‐Henry Robert D. , Lin Betty , Neff Dylan , Shakiba Nila , Conradt Elisabeth , Crowell Sheila E. 
Published: May 2021

AbstractThere is limited understanding of factors across the lifespan that influence pregnant women's respiratory sinus arrhythmia (RSA), which could have implications for their health and offspring development. We examined associations among 162 English‐ and Spanish‐speaking pregnant women's childhood maltreatment history, emotion dysregulation, recent life stress, and resting RSA during the third trimester. Moderated mediation analyses indicated that more severe childhood maltreatment history (95% confidence interval (CI) [0.26, 0.63]) and higher emotion dysregulation (95% CI [0.001, 0.006]) predicted more stress during pregnancy, and childhood maltreatment history interacted with emotion dysregulation to predict resting RSA (95% CI [−0.04, −0.0003]). Exploratory analyses revealed that women's health‐related stress during pregnancy mediated the relation between emotion dysregulation and RSA regardless of childhood maltreatment severity (95% CI [−0.007, −0.002]). These findings suggest that women's resting RSA during pregnancy may reflect physical and emotional stress accumulation across the lifespan and that relations between early life adversity and prenatal psychophysiology may be buffered by protective factors, such as emotion regulation. In addition, these findings underscore the importance of distinguishing between types of prenatal stress. Given the implications for women's health and offspring development, we urge researchers to continue exploring factors associated with pregnant women's psychophysiology.
Pubertal transition with current life stress and support alters longitudinal diurnal cortisol patterns in adolescents exposed to early life adversity
Authors: Reid Brie M. , DePasquale Carrie E. , Donzella Bonny , Leneman Keira B. , Taylor Heather , Gunnar Megan R. 
Published: May 2021

AbstractCurrent and early life stress (ELS) are associated with diurnal cortisol patterns, which themselves are associated with mental and physical health. The pubertal recalibration hypothesis suggests that the social environment can impact dysregulated cortisol patterns for previously ELS‐exposed youth as they transition through puberty. This study examined longitudinal change in cortisol awakening response (CAR) and diurnal slope (DS) across puberty as a function of ELS in infancy, current stress, and social support (N = 290, 7–17 years). The CAR and DS were examined thrice annually with an accelerated longitudinal design with nurse‐assessed puberty to assess associations between diurnal cortisol and pubertal recalibration with ELS and the current social environment. Exposure to ELS was associated with less steep DS but not changes in CAR, and no evidence of pubertal calibration was found. The DS became less steep for youth in later pubertal stages and as youth progressed through puberty. The CAR was steeper for youth in later pubertal stages. Across the cohort, current life stress and support were associated with changes in the DS and the CAR through the pubertal transition. The pubertal stage and the peripubertal and pubertal social environment may have important implications for adrenocortical functioning with or without exposure to ELS.