bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D tumor spheroid microarray for high-throughput, high-content natural killer cell-mediated cytotoxicity
Authors: Gopal Sneha , Kwon Seok-Joon , Ku Bosung , Lee Dong Woo , Kim Jungeun , Dordick Jonathan S. 
Published: July 2021

AbstractImmunotherapy has emerged as a promising approach to treating several forms of cancer. Use of immune cells, such as natural killer (NK) cells, along with small molecule drugs and antibodies through antibody dependent cell-mediated cytotoxicity (ADCC) has been investigated as a potential combination therapy for some difficult to treat solid tumors. Nevertheless, there remains a need to develop tools that support co-culture of target cancer cells and effector immune cells in a contextually relevant three-dimensional (3D) environment to provide a rapid means to screen for and optimize ADCC-drug combinations. To that end, here we have developed a high throughput 330 micropillar-microwell sandwich platform that enables 3D co-culture of NK92-CD16 cells with pancreatic (MiaPaCa-2) and breast cancer cell lines (MCF-7 and MDA-MB-231). The platform successfully mimicked hypoxic conditions found in a tumor microenvironment and was used to demonstrate NK-cell mediated cell cytotoxicity in combination with two monoclonal antibodies; Trastuzumab and Atezolizumab. The platform was also used to show dose response behavior of target cancer cells with reduced EC50 values for paclitaxel (an anti-cancer chemotherapeutic) when treated with both NK cells and antibody. Such a platform may be used to develop more personalized cancer therapies using patient-derived cancer cells.
The Horseshoe Abyssal plain Thrust could be the source of the 1755 Lisbon earthquake and tsunami
Authors: Martínez-Loriente Sara , Sallarès Valentí , Gràcia Eulàlia 
Published: July 2021

AbstractThe southwest Iberia margin is widely believed to have hosted the 1755 Great Lisbon earthquake and ensuing tsunami, one of the most destructive natural events in European history. Here we combine geophysical data and numerical tsunami modelling to investigate the source and mechanism responsible for this event. We find that an intra-plate, lithospheric¬-scale thrust fault located at the Horseshoe Abyssal Plain coincides with the location and focal mechanisms of the largest regional earthquakes and is likely to have suitable dimensions and fault-rock properties to account for the magnitude of the 1755 event. We present tsunami simulations with this fault as the source, and find that they reproduce reported tsunami energy propagation patterns, arrival-times and run up heights more successfully than other modelled sources. We propose that a reverse dip-slip mechanism on the northwest verging Horseshoe Abyssal plain Thrust, combined with the two-state mechanical behaviour of serpentinite, is the most likely candidate for the source of the 1755 Great Lisbon earthquake and for other recent large regional earthquakes.
Exploration of the molecular targets and mechanisms of suxiao xintong dropping pills for myocardial infarction by network pharmacology method
Authors: Chen Daqiu , Wu Yanqing , Chen Yixing , Chen Qiaoxing , Ye Xianhua , Xu Shanghua , Luo Shunxiang 
Published: July 2021

Abstract
Background: Suxiao Xintong dropping pills (SXXTDP), a traditional Chinese medicine, is widely applied for treating myocardial infarction (MI). However, its therapy mechanisms are still unclear. Therefore, this research is designed to explore the molecular mechanisms of SXXTDP in treating MI.
Methods: The active ingredients of SXXTDP and their corresponding genes of the active ingredients were retrieved from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. MI-related genes were identified via analyzing the expression profiling data (accession number: GSE97320). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed to study the shared genes of drug and disease. Through protein–protein interaction (PPI) network and the Cytoscape plugin cytoHubba, the hub genes were screened out. The compounds and hub targets binding were simulated through molecular docking method.
Results: We obtained 21 active compounds and 253 corresponding target genes from TCMSP database. 1833 MI-related genes were identified according to P&lt;0.05 and |log2FC| ≥ 0.5. 27 overlapping genes between drug and disease were acquired. GO analysis indicated that overlapping genes were mainly enriched in MAP kinase activity and antioxidant activity. KEGG analysis indicated that overlapping genes were mainly enriched in IL-17 signaling pathway and TNF signaling pathway. We obtained 10 hub genes via cytoHubba plugin. Six of the 10 hub genes, including PTGS2, MAPK14, MMP9, MAPK1, NFKBIA, and CASP8, were acted on molecular docking verification with their corresponding compounds of SXXTDP.
Conclusion: SXXTDP may exert cardioprotection effect through regulating multiple targets and multiple pathways in MI.
Graduate Students' Perspectives Toward Telepractice at the COVID-19 Global Pandemic Onset
Authors: McGill Megann , Dennard Qiana 
Published: July 2021

Purpose
The purpose of this article was to describe a cross-sectional research study exploring the perceived knowledge, skills, and attitudes of telepractice service delivery use among speech-language pathology graduate students during the onset of the COVID-19 global pandemic.

Method

Students' perceived knowledge, skills, and attitudes toward telepractice were examined through an online questionnaire that contained 23 questions, including five demographic questions and 18 Likert scale questions. Participants were 189 graduate students (96% female, 60% first-year graduate students) currently enrolled in speech-language pathology graduate programs. Statistical analyses on students' responses, including independent-samples
t
tests and correlations, were conducted.

Results
Only 20% of respondents stated they had provided services via telepractice. Most participants reported slightly more confidence in their perceived skills related to telepractice as compared to their perceived knowledge of telepractice. Students who had prior experience with telepractice were more likely to provide higher ratings compared to those with no experience. Higher ratings of perceived telepractice knowledge and skills were observed for second-year and third-year graduate students compared to first-year students. Positive correlations were observed between students' higher confidence in perceived knowledge and skills related to telepractice and their attitudes toward the service delivery model. Despite positive responses related to perceived telepractice knowledge and skills, the majority of participants reported preferring in-person services over telepractice.

Conclusions
Taken together, results of this study demonstrate there is an ongoing need for additional telepractice training programs in speech-language pathology focusing on areas in which students feel least comfortable. Telepractice clinical implications and graduate program training recommendations are discussed.
A Review of Mindfulness and Communication Sciences and Disorders Students
Authors: Beck Ann R. 
Published: July 2021

Purpose
The purpose of this review article was to define mindfulness and discuss its use with college students, students majoring in clinical programs, and communication sciences and disorders (CSD) students in particular.

Method
Literature was reviewed regarding mindfulness, stress, perfectionism, and self-compassion. Furthermore, how these issues relate to college students in general, students in clinically related majors, and specifically to CSD students was discussed. Research using a mindfulness practice with CSD students was reviewed and two methods of incorporating a mindfulness practice into an ongoing CSD curriculum (i.e., as part of a graduate course on counseling and as part of an undergraduate course on the graduate application process) were discussed.

Results
A short mindfulness practice has been found to decrease the perceived and biological stress levels of CSD undergraduate and graduate students. Participation in this practice has also been found to help CSD students ameliorate negative aspects of perfectionism and to increase self-compassion. Use of the mindfulness practice within the curriculum was accepted by students.

Conclusion
The use of a short mindfulness practice can successfully be incorporated into an ongoing CSD curriculum and appears to be an effective method of improving students' overall well-being.
Linearised three‐phase optimal power flow for coordinated optimisation of residential solid‐state power substations
Authors: Liu Guodong , Moorthy Radha S. , Choi Jongchan , Chinthavali Madhu S. 
Published: July 2021

AbstractWith the increasing integration of single‐phase resources, for example, PV, batteries and solid‐state power substations (SSPSs), in residential distribution networks, voltage regulation and phase balancing of distribution feeders are facing growing challenges. To solve these challenges, a linearised three‐phase optimal power flow (OPF) model is proposed to coordinate the operation of residential solid‐state power substations for voltage regulation and phase balancing of distribution feeders. The proposed three‐phase OPF model schedules both real and reactive power of each components in the SSPSs with the purpose of minimising the total operating cost as well as improving the grid performance, for example, voltage regulation and phase balancing. Results of case studies validate the accuracy of the proposed three‐phase OPF model. In addition, the effectiveness of coordinating multiple SSPSs for voltage regulation and phase balancing has been demonstrated.
Magnetic microswimmers with infrared‐induced shape transformation
Authors: Yang Runhuai , Zhu Shilu , Zhang Lijiu , Niu Fuzhou , Liu Shuang 
Published: July 2021

AbstractSoft untethered microswimmers have recently been demonstrated to be capable of transporting and delivering cargos by external control while maintaining biocompatibility and safety. However, such microswimmers still suffer from complex and inconvenient fabrication processes and control methods, which impedes their clinical translation. In this paper, an easy‐to‐fabricate, magnetic‐driven and IR‐induced shape transformative microswimmer is presented. This microswimmer can be fabricated in a fast, low‐cost and high‐throughput manner. Besides, the soft body of the microswimmer can provide an inherent friendly contact with the biological environment, and its components are biocompatible and biodegradable. Being magnetically‐drivable allows the microswimmer to provide untethered movement and targeted therapy in the human body, and its IR‐induced shape transformability enables penetrable regulation of the movement and function. Furthermore, the shape of the untethered microswimmer can be transformed due to its combination of low melting behaviours and multi‐response materials, suggesting that other materials with similar properties can also be adopted in a similar method. The proposed method validates the feasibility to integrate polymers for fabricating magnetic‐driven, infrared‐responsive and shape transformative microswimmers.
Extending the horizontal transmission range of an inductive wireless power transfer system using passive elliptical resonators
Authors: Alexandru Cristina A. , Zhu Dibin 
Published: July 2021

AbstractThis paper investigates the development of a passive elliptical planar coil for extending the horizontal transmission distance in an inductive transmitter‐receiver wireless‐power transfer system (WPT). The passive base coil partially overlaps the transmitter coil and extends the horizontal wireless link between the transmitter and receiver. The base coil models investigated are divided into three categories based on their length. Moreover, for each length category, the optimum number of turns is determined. All proposed models are analysed through the electromagnetic simulation (EMF) software Ansys–Maxwell and Simplorer as well as validated experimentally. For the entire analysis, the maximum efficiency principle is followed in this system. Therefore, impedance matching networks are used across all three terminals in order to tune the system to the operating frequency of 200 kHz to achieve maximum efficiency. The maximum achievable efficiency is determined for each coil prototype (in both simulation and experiment) and the results are compared. The extent to which the EMF software is a valuable tool in developing a planar passive base for an inductive WPT system is discussed. Overall, the proposed concept behind the passive base coil is proved to be successful in extending the horizontal distance between the transmitter and receiver.
Constraining bright optical counterparts of fast radio bursts
Authors: Núñez C. , Tejos N. , Pignata G. , Kilpatrick C. D. , Prochaska J. X. , Heintz K. E. , Bannister K. W. , Bhandari S. , Day C. K. , Deller A. T. , Flynn C. , Mahony E. K. , Majewski D. , Marnoch L. , Qiu H. , Ryder S. D. , Shannon R. M. 
Published: July 2021

Context.Fast radio bursts (FRBs) are extremely energetic pulses of millisecond duration and unknown origin. To understand the phenomenon that emits these pulses, targeted and un-targeted searches have been performed for multiwavelength counterparts, including the optical.Aims.The objective of this work is to search for optical transients at the positions of eight well-localized (< 1″) FRBs after the arrival of the burst on different timescales (typically at one day, several months, and one year after FRB detection). We then compare this with known optical light curves to constrain progenitor models.Methods.We used the Las Cumbres Observatory Global Telescope (LCOGT) network to promptly take images with its network of 23 telescopes working around the world. We used a template subtraction technique to analyze all the images collected at differing epochs. We have divided the difference images into two groups: In one group we use the image of the last epoch as a template, and in the other group we use the image of the first epoch as a template. We then searched for optical transients at the localizations of the FRBs in the template subtracted images.Results.We have found no optical transients and have therefore set limiting magnitudes to the optical counterparts. Typical limits in apparent and absolute magnitudes for our LCOGT data are ∼22 and −19 mag in therband, respectively. We have compared our limiting magnitudes with light curves of super-luminous supernovae (SLSNe), Type Ia supernovae (SNe Ia), supernovae associated with gamma-ray bursts (GRB-SNe), a kilonova, and tidal disruption events (TDEs).Conclusions.Assuming that the FRB emission coincides with the time of explosion of these transients, we rule out associations with SLSNe (at the ∼99.9% confidence level) and the brightest subtypes of SNe Ia, GRB-SNe, and TDEs (at a similar confidence level). However, we cannot exclude scenarios where FRBs are directly associated with the faintest of these subtypes or with kilonovae.
Bindungsförderung
Authors: Krahl Astrid 
Published: July 2021

Was Frauen und Eltern beim Umgang mit dem Neugeborenen und beim Bindungsaufbau unterstützt
Wie können wir Mütter und Eltern beim Bindungsaufbau unterstützen? Dieser Frage gehen die Autorinnen der Schwerpunktartikel der vorliegenden Ausgabe nach.
Conventional tagging of sharks in Western Australia: the main commercial species exhibit contrasting movement patterns
Authors: Bartes Saia , Simpfendorfer Colin , Walker Terence I. , King Carissa , Loneragan Neil , Braccini Matías 
Published: July 2021

Understanding movement patterns underlies effective management and conservation measures. The current study summarises the main findings from a tagging program of Western Australian sharks to provide insights into the movement patterns of the main commercial shark species: dusky (Carcharhinus obscurus), sandbar (C. plumbeus), gummy (Mustelus antarcticus) and whiskery (Furgaleus macki) sharks. Between 1993 and 2020, >12 000 individuals from 52 taxonomic groups were implanted with conventional tags in Western Australia, of which 8.5% were recaptured. Most of the tagged (74.5%) and recaptured (95.8%) individuals belong to the four main commercial shark species. Recaptured individuals of these species, as well as tiger (Galeocerdo cuvier) and bronze whaler (C. brachyurus) sharks showed displacements of >1000 km and rates of movement (ROMs) of >10 km day–1, with the exception of whiskery sharks, which showed much slower ROMs (<3 km day–1). Despite tagged dusky and sandbar sharks being predominately small individuals and gummy and whiskery sharks being large individuals, dusky and sandbar sharks had faster ROMs and a greater proportion of recaptures outside the release zone. Our study provided the information required for estimating movement rates across different fishing zones and therefore defining the spatial scale for managing these shark species.
Experience Design for the Dutch Fort, Batticaloa, Sri Lanka
Authors: Pathirana Madura , Scott Noel 
Published: July 2021

Abstract
The Batticaloa Dutch Fort is over 400 years old and has been occupied by the Portuguese, Dutch, British and Sri Lankan governments. The local government wants to develop the fort as a cultural heritage tourist attraction, displaying the history and traditional culture of the Batticaloa region. Attracting international and domestic visitors requires designing an activity that is of interest to these visitors. Develop a proposal for a 1–2-hour experiential activity at the fort.

Information
© CAB International 2021
Exploring the Case Solar Technology Lowers the Noise Level in the Waters Surrounding Bora Bora
Authors: Ward-Perkins David 
Published: July 2021

Introduction
The management of coastal and marine environments is of interest to all professionals and students of tourism. Such environments are particularly attractive to tourists; indeed, they have in many cases been ‘loved to death’ – damaged beyond repair by tourist activity. There is an evident link between protection from tourist activity and the biodiversity and ecological health of the waters that tourists swim in, and from which are caught the fish and crustaceans they dine on.
It is therefore encouraging to read about technical solutions that can assist in this protection. In this Exploring the Case, we make reference to the Soel Yachts Case Study but also to an article by Douglas McCauley, a professor of marine biology who has written about the use of tracking technologies, such as by satellite.
These two sources are a good starting point for research into the protection of ocean environments.
Simulating the evolution of bipedalism and the absence of static bipedal hexapods
Authors: Rong Chunyan , Zhu Jiahui , Giardina Fabio , Rosendo Andre 
Published: July 2021

Abstract
In nature, very few animals locomote on two legs. Static bipedalism can be found in four limbed and five limbed animals like dogs, cats, birds, monkeys and kangaroos, but it cannot be seen in hexapods or other multi-limbed animals. In this paper, we present a simulation with a novel perspective on the evolution of static bipedalism, with a virtual creature evolving its body and controllers, and we apply an evolutionary algorithm to explore the locomotion transition from octapods to bipods. We find that the presence of four limbs in the evolutionary trajectory of the creature scaffolds a parametric jump that enables bipedalism, and shows that hexapods, without undergoing such transformation, struggle to evolve into bipeds. An analysis of the transitional parameters points to the role of a shorter femur length in helping maintain the stability of the body, and the tibia length is responsible for improving the forward speed.
Improved modelling of soil NO
x
emissions in a high temperature agricultural region: role of background emissions on NO2 trend over the US
Authors: Wang Yi , Ge Cui , Castro Garcia Lorena , Jenerette G Darrel , Oikawa Patty Y , Wang Jun 
Published: July 2021

Abstract
EPA reports a steady decline of US anthropogenic NO
x
emissions in 2005–2019 summers, while NO2 vertical column densities (VCDs) from the OMI satellite over large spatial domains have flattened since 2009. To better understand the contributing factors to a flattening of the OMI NO2 trends, we investigate the role of soil and lightning NOx emissions on this apparent disagreement. We improve soil NO
x
emissions estimates using a new observation-based temperature response, which increases the linear correlation coefficient between GEOS-Chem simulated and OMI NO2 VCDs by 0.05–0.2 over the Central US. Multivariate trend analysis reveals that soil and lightning NO
x
combined emissions trends change from −3.95% a−1 during 2005–2009 to 0.60% a−1 from 2009 to 2019, thereby rendering the abrupt slowdown of total NO
x
emissions reduction. Non-linear inter-annual variations explain 6.6% of the variance of total NO
x
emissions. As background emissions become relatively larger with uncertain inter-annual variations, the NO2 VCDs alone at the national scale, especially in the regions with vast rural areas, will be insufficient to discern the trend of anthropogenic emissions.
Habeas Corpus: A Very Short Introduction
Authors: Tyler Amanda L. 
Published: July 2021

Abstract
For nearly eight hundred years, the writ of habeas corpus has limited the executive in the Anglo-American legal tradition from imprisoning persons with impunity. Writing in the eighteenth century, William Blackstone declared the writ a “bulwark” of personal liberty. Across the Atlantic, in the lead up to the American Revolution, the Continental Congress declared that the habeas privilege and the right to jury trial were among the most important rights in a free society. This Very Short Introduction chronicles the storied writ of habeas corpus and how it spread from England throughout the British Empire and beyond, witnessing its use today all around the world. Beginning with the English origins of the writ, the book traces its historical development as a part of the common law and as grounded in the English Habeas Corpus Act of 1679, a statute that dramatically limited the executive's power to detain and that Blackstone called no less than a “second Magna Carta.” The book then takes the story forward to explore how the writ has functioned in the centuries since, including its controversial suspension by President Abraham Lincoln during the Civil War. It also explores the role of habeas corpus during World War II and the War on Terror. The story told in these pages reveals the immense challenges that the habeas privilege faces today and suggests that in confronting them, we would do well to remember how the habeas privilege brought even the king of England to his knees before the law.
Civil war and suspension
Authors: Tyler Amanda L. 
Published: July 2021

Abstract
This chapter details the American Civil War and President Abraham Lincoln’s role in acting quickly—and controversially—to protect critical areas in the North by claiming the unilateral power to suspend habeas. As is explored in the chapter, Lincoln proclaimed suspensions on his own and without congressional approval for some two years until the US Congress finally enacted suspension legislation. Along the way, Lincoln’s actions provoked a rebuke from the Chief Justice of the United States in Ex parte Merryman and raised important separation of powers questions. The chapter also explores how after the war, the Supreme Court held in Ex parte Milligan that the laws of war could not be applied to “citizens in states which have upheld the authority of the government, and where the courts are open and their process unobstructed.” Finally, the chapter discusses the precedent established by Lincoln’s actions.