bluuebunny/crossref_metadata_2025_split huggingface dataset:
НАТРИЙ ДИТИОФОСФАТЫНЫҢ МАРГАНЕЦ РУДАЛАРЫНЫҢ ҮЛГІЛЕРІНЕ ҚАТЫСТЫ ФЛОТАЦИЯЛЫҚ ҚАБІЛЕТІНЕ ЖИНАҒЫШТАР ШЫҒЫМЫНЫҢ ӘСЕРІ
Authors: Султанова Л. , Мусина Г. , Аманжолова А. , Ерланова К. , Аяпберген М. 
Published: December 2024

Мақалада натрий дитиофосфатының марганец рудаларын байыту кезіндегі флотациялық қабілетіне жинағыш реагенттердің мөлшерінің әсері зерттелген. Қазіргі кезде минералды шикізаттарды байыту және өңдеу маңызды орын алады, себебі олардың құрамындағы пайдалы заттарды тиімді пайдалану үшін арнайы әдістер қолдану қажет. Жұмыста минералдарды физика-химиялық қасиеттері бойынша бөлу үшін кеңінен қолданылатын флотациялық процестерге баса назар аудара отырып, пайдалы қазбаларды байыту әдістері қарастырылады. Жұмыстың мақсаты - марганец кендерінің флотациялық қабілетіне натрий дитиофосфатының әртүрлі концентрациясының әсерін зерттеу және оның байыту процесінде тиімділігін бағалау. Зерттеу барысында әртүрлі реагенттерді қолдану арқылы флотация процесінің көрсеткіштері анықталды. Сонымен қоса, марганец рудаларының флотациялық процестері мен реагенттердің әсері талданды, соның ішінде натрий дитиофосфатының байытудағы рөлі мен оның тиімділігіне ерекше назар аударылды. Тәжірибелік бөлімде флотациялық процестердің әдістемесі және электромагниттік өріспен әсер ету арқылы байыту жолдары қарастырылған. Мақалада натрий дитиофосфатын және басқа реагенттерді қолдана отырып флотациялық тәжірибелер жүргізу, сондай-ақ байыту процесін жақсарту үшін электромагниттік өрісті қолдану ұсынылған. Флотациялық комплекс «флотореагент-бөлшек» поляризацияланады және бағыттаушы немесе қозғаушы күш болатын магнитті өрістің әсеріне ұшырайды. Бұл комплекс оң зарядталады, сондықтан теріс электродта разрядталады. Жұмыстың нәтижелері бойынша реагенттерді тұтынуды оңтайландыру соңғы өнімнің сапасын жақсарту және байыту шығындарын азайту арқылы флотация процесінің тиімділігін айтарлықтай арттыра алатынын көрсетеді. Электромагниттік өріс әсерінен байыту артықшылығы көпірткіш қосылмайды және флотореагенттің шығымы аз. Флотация процесіне қарағанда процесс ұзақтығы төменірек. Сондықтан байытудың бұл түрін қолдану экономикалық тұрғыдан тиімді.
ISLAMIC COUNSELING (BEHAVIOUR THEORY) IN DEALING WITH TRUANT BEHAVIOUR
Authors: Hafsoh Fadilla Fariza , Subhi Muhamad Rifa'i 
Published: December 2024

Truancy behavior in students is a problem that often occurs in schools, with many factors behind it. The urgency of this research is to discuss ideal lessons, aspects of truancy, the impact of truancy. Uniquely, this research is based on one of the theories in psychology, namely the behavior theory coined by Burrhus Federick Skinner. Behaviorism theory is also applied to group guidance and individual counseling. The research method used in this research is qualitative, field research type with data collection techniques using interviews, the analysis method used is descriptive analytical. The results after interviews with BK teachers at SMP Darul Hikam skipping class have various causes both internal and external. Prevention of skipping class by creating a pleasant learning atmosphere such as interspersed with games. After several times of group guidance and individual counseling by applying behavior theory to children who skipped class, the child began to leave his habit of skipping class. According to the counseling teacher, the counseling above will be more effective coupled with other theories such as humanistic, CBT and REBT.
Study on Stunting, Underweight and Wasting among Under-Five Children in India: Changes with Respect to Age
Authors: Bharati Susmita , Pal Manoranjan , Hossain Md Golam , Bharati Premananda 
Published: December 2024

Nutrition is a basic need of human life and a prerequisite for a healthy life, good health of children is very important for future development of the country. This paper examines the nutritional status of under-five children in India. A total number of 168942 under-five children in India have been considered in the sample for the study. The data has been taken from the fifth national family health survey of 2019-21, India. Children who fall below –2SD from the median of the respective Z-scores of ‘weight for age’ (WAZ), ‘height for age’ (HAZ) and ‘weight for height’ (WHZ) are considered as underweight, stunted and wasted respectively. Prevalence of underweight, stunted and wasted children are 29.2%, 35.4% and 18.7% respectively and boys were more prevalent than girls. Also, child undernutrition tends to decrease with the mother's level of education, the mother's health status, and the wealth index of the family. Child’s health is also directly related with oropharyngeal administration of colostrum to baby. The results show that the mean values of height and weight steadily increase all along the ages up to 59 months. Growth patterns and the prevalence of undernutrition are almost the same among girls and boys. The prevalence of undernutrition (WAZ and HAZ) increases up to the child’s age group of 12-23 months, and then decreases slightly thereafter or remains more or less same, but for WHZ it decreases throughout. It is seen from our study that in both the sexes of under-five children, underweight is directly and wasting is indirectly related with the ages, but no clear association is seen in stunting. The study also points out the necessity of improving mothers' education, awareness of health, in addition to the economic condition of the families, to overcome the undernutrition of under-five children.
IJSS, Vol. 24(2)s (Special Issue), December, 2024, pp 137-148
Implementasi Media Kartu Bergambar Untuk Meningkatkan Kemampuan Membaca Permulaan Pada Anak Usia Dini 5-6 Tahun Di PAUD SPS Bougenvil Desa Mekarsari Kecamatan Ciracap Kabupaten Sukabumi
Authors: Nurajijah Nurajijah , Munajat Asep , Hurri Ibnu 
Published: December 2024

Kemampuan membaca permulaan merupakan bagian penting dari perkembangan anak usia dini. Di jenjang pendidikan usia dini, guru mengajarkan kemampuan membaca permulaan. Dalam rangka meningkatkan kemampuan membaca permulaan anak usia dini banyak media yang dapat digunakan salah satunya media kartu bergambar. Berdasarkan hal tersebut maka pada penelitian ini akan diteliti mengenai penerapan media kartu bergambar untuk meningkatkan kemampuan membaca permulaan. Metode penelitian yang digunakan adalah penelitian kualitatif dengan desain penelitian studi kasus. Teknik pengumpulan data yang digunakan dalam penelitian ini dengan menggunakan observasi, wawancara, studi dokumentasi, dan partisipan. Analisis data menggunakan Miles dan Huberman. Hasil dari penggunaan media kartu bergambar untuk meningkatkan kemampuan anak dalam membaca permulaan menunjukkan hasil yang baik. Di mana berdasarkan hasil observasi maupun wawancara menunjukkan dari 22 orang anak di PAUD SPS Bougenvil sebagian besar anak sudah dapat membaca permulaan. 17 anak setara dengan 77,27% sudah mahir membaca dan sisanya sebanyak 5 anak setara dengan 22,73% belum mahir membaca permulaan.
Growth Performance, Digestive Enzymes Activities and Gut Microbiota of Malaysian Mahseer, Tor tambroides Fingerlings Affected by Various Probiotics Concentrations
Authors: CHUA SING YING , MUNIR MOHAMMAD BODRUL , LANANAN FATHURRAHMAN , ASDARI ROSLIANAH 
Published: December 2024

The most valued freshwater fish in Malaysia is the Malaysian mahseer, Tor tambroides, also known as Empurau. Due to the extended growing period, innovative feeding management is required to maintain fish health. This study looked at the effect of Lacto-sacc, a feed additive and antibiotic replacement made up of Lactobacillus acidophilus, Saccharomyces cerevisiae and Enterococcus faecium, on T. tambroides fingerlings’ growth performance, digestive enzyme activities and gut microbiota. A total of 600 fingerlings, each weighing 6.53 g ± 0.17 g, were allocated into twelve 650 L tanks, with 50 fingerlings per tank. Over a period of 20 weeks, the fish were fed four different diets: 0% Lacto-sacc as control (A), 0.5% Lacto-sacc (B), 1.0% Lacto-sacc (C), and 1.25% Lacto-sacc (D), with each diet replicated in three tanks. Although statistic revealed no significant differences in growth performance among treatment group (p>0.05), but it is noteworthy that fingerlings of T. tambroides were fed a diet containing 0.5% Lacto-sacc exhibited a trend toward improved growth performance with value higher SGR, along with elevated lipase and protease activities than other groups. Fusobacteria, Proteobacteria, Bacteroidetes, Firmicutes were the top four phyla in the gut microbiota of T. tambroides, accounting for more than 95%, with Fusobacteria dominating at around 70% of the gut microbiota. Cetobacterium, ZOR0006, Brevinema, and Aeromonas were the most common genera detected. T. tambroides fed a 0.5% Lacto-sacc (B) diet had lower Fusobacteria abundance while increasing other dominating bacteria compared to other treatments. Although there is no significant difference in gut microbiota, the gut microbiota of T. tambroides fed probiotics was more consistently disturbed and diversified, indicating less species dominance. The addition of Lacto-sacc, particularly at a concentration of 0.5%, appeared to enhance growth performance and increase the activity of digestive enzymes compared to the diet without Lacto-sacc, although the results were not statistically significant.
Analysis Of The Effect Of Leverage On Company Value (Study PT case. Gajah Tunggal Tbk 2019-2022)
Authors: Wijaya S. , Masniah A. 
Published: December 2024

Company PT. Gajah Tunggal Tbk is the largest tire in Asia especially in Asia southeast . Founded in 1971 and in 1990 officially has offices at the Jakarta Stock Exchange and the Surabaya Stock Exchange . This company located in Jakarta and has factory in town attack and tangerang For support activity the production . objective study This This is For analyze the effect of leverage on mark company PT. Gajah Tunggal Tbk 2020-2022 . Method writing this paper using Grand Theory where to be base the theory are Leverage and Company Value. Grand Theory is something that becomes base birth theory Where theory the Still nature macro or wide Then formulated at the next level . In this paper using quantitative data Where data sources used is secondary data that comes from from report PT finance . Gajah Tunggal Tbk . 2019-2022 . Based on Measurable Leverage serving with Debt to Assets Ratios and Company Value are measured with using the Price to Book Value (PBV) of The years 2019 – 2022 show that PT. Gajah Tunggal Tbk has Debt to Assets The ratio (DAR) is in the GOOD CATEGORY based on category Cashmere (2016) in Fitria (2022). However Debt to Asset value The ratio (DAR) is still ≥ 0.5 according to moneyduck.com.id (2022) including . This matter show that part big asset company financed by debt . Whereas mark company PT. Gajah Tunggal Tbk is calculated through Price to Book Value (PBV) is in the UNDERVALUED CATEGORY .
Efficacy and safety of pegylated liposomal doxorubicin and epirubicin as neoadjuvant chemotherapy for breast cancer
Authors: Shen Yuanyuan , Hua Qingling , Dong Menghao , Jin Wei , Hu Xueyang , Gu Kangsheng 
Published: December 2024

AimThis study aims to compare the efficiencies and toxicities of pegylated liposomal doxorubicin (PLD) based and epirubicin based chemotherapeutic regimens as neoadjuvant chemotherapy (NAC) for early breast cancer.Patients and methodsWe retrospectively analyzed 391 patients with stage II-III breast cancer who received NAC in multiple centers. The efficiencies and toxicities of PLD and epirubicin based NAC regimens were compared by using both propensity-score matched (PSM) and unmatched data. The status of relevant gene loci was detected through next-generation sequencing (NGS) technology and the correlation between mutations of genes and serious adverse events (AEs) was preliminarily analyzed.ResultsA total of 391 patients were included in this study. Among them, 235 patients received PLD based NAC (PLD group), and the other 156 patients were administrated with EPI based NAC (EPI group). The pathological complete response (pCR) rate of patients in PLD group was significantly higher than EPI group (before PSM:32.3% vs. 23.1%; after PSM:42.5% vs. 24.7%). Most severe AEs of patients in EPI group were more than PLD group (before PSM: 1.3%–37.8% vs. 0%–10.6%; after PSM: 1.4%–37.0% vs. 0%–9.6%). Mutation rates of 7 gene (MTHFR, DPYD, NQO1, ERCC1, UGT1A1, TYMS and TP53) of patients with severe AEs were significantly higher compared with patients with slight AEs (grade 1/2) or without AEs.ConclusionPLD based chemotherapeutic regimen is a viable option for NAC of breast cancer. Epirubicin should be avoided for patients with mutations of some specific genes considering the potential severe AEs.
Efficacy of natural NF-κB inhibitors in the treatment of fibrosarcoma: an in vitro model study
Authors: Radzka Justyna , Gizak Agnieszka , Drąg-Zalesińska Małgorzata , Haczkiewicz-Leśniak Katarzyna , Kulus Michał , Szewczyk Anna , Szlasa Wojciech , Podhorska-Okołów Marzenna , Kulbacka Julita 
Published: December 2024

IntroductionNF-κB plays a pivotal role in the progression of cancers, including myosarcomas such as fibrosarcoma. Plants possess considerable potential for the provision of chemotherapeutic effects against cancer. The present study assessed, among others, the cytotoxicity, migration capacity and DNA damage induced by several natural compounds (berberine, curcumin, biochanin A, cucurbitacin E (CurE) and phenethyl caffeic acid (CAPE)) in cancer cells (WEHI-164) and normal muscle cells (L6).MethodsIC50 parameter was determined for all substances after 24-hour incubation. Molecular docking studies were performed to assess compound binding to cytoskeletal proteins. Neutral comet assay and immunocytochemical analysis were used to assess the intensity of apoptosis, and transmission electron microscopy was employed to validate these results at the ultrastructural level.Results and DiscussionThe results showed that the tested compounds had a significantly increased cytotoxic effect on cancer cells compared to normal cells. Furthermore, molecular docking studies indicated that CAPE, biochanin A, and CurE could inhibit actin polymerization, suggesting their potential role in disrupting the cytoskeleton of cancer cells. Increased expression of caspase-3 and PARP-1 in WEHI-164 cells after treatment indicated the induction of apoptosis. Transmission electron microscopy confirmed the presence of cellular stress and vacuolation in cells treated with these compounds, with more pronounced effects observed in cancer cells compared to normal cells. The results indicate that natural NF-κB inhibitors may be capable of selectively targeting cancer cells, reducing their viability and inducing apoptosis while sparing normal cells. This selectivity is of great importance for the development of safer anticancer therapies. The results of this research support the hypothesis that these natural compounds may be effective anticancer agents, particularly in the treatment of fibrosarcoma. Further, in vivo studies and clinical trials are required to gain a full understanding of their mechanisms of action and potential synergies with existing chemotherapeutic agents.
Zebrafish as a model system for studying reproductive diseases
Authors: Zha Wenwen , Hu Weitao , Ge Chenkai , Chen Jianjun , Cao Zigang 
Published: December 2024

Reproductive system diseases have become a major health challenge facing humans, so extensive investigations are needed to understand their complex pathogenesis and summarize effective treatments. In the study of reproductive diseases, mice are the most commonly used animal model. However, the cost and time required to establish mouse animal models are high. The existing zebrafish model can solve this problem well. Zebrafish is an animal model with great application prospects and has lots of advantages, including high degree of genetic conservation with humans, short reproductive cycle, transparent embryos, and rapid growth, providing unique opportunities for high-throughput drug screening and identification of potential treatments. Researchers have successfully used chemical induction, physical damage, gene editing technology, etc., to induce reproductive system damage in zebrafish to study the biological processes related to its reproductive diseases. Therefore, in this review, the main models and related advantages of zebrafish in reproductive diseases are summarized, the pathological mechanisms of zebrafish as a reproductive disease model are clarified, and new perspectives and valuable insights are provided for the treatment of human reproductive diseases. The literature and data cited in the review are all from PubMed, covering important research results on zebrafish reproductive diseases in the past 10 years.
A non-linear association of low-density lipoprotein cholesterol with all-cause and cardiovascular mortality among patients with hypertension
Authors: Liang Guoliang , Zhang Wenhao , Gu Xinxin , Zhang Qiong , Liu Ankang , Qing Xinran , Ma Jiangwei 
Published: December 2024

BackgroundAlthough a few studies have examined the correlation between low-density lipoprotein cholesterol (LDL-C) and mortality, no study has explored these associations in hypertensive populations. This study aims to investigate the relationship between low-density lipoprotein cholesterol and cardiovascular and all-cause mortality in adults with hypertension.MethodsHypertensive participants aged ≥18 years from the National Health and Nutrition Examination Survey 1999–2018 with blood lipid testing data and complete follow-up data until 31 December 2019 were enrolled in the analysis. Univariate and multivariate Cox regression were conducted for the calculation of hazard ratios and 95% confidence intervals. A restricted cubic spline curve was performed to visually represent the relationship between LDL-C and mortality. Kaplan–Meier survival analysis and stratification analysis were also carried out.ResultsWe finally analysed a cohort of 9,635 participants (49.6% male, mean age of 59.4 years). After a median follow-up of 98 months, there were 2,283 (23.7%) instances of all-cause fatalities, with 758 (7.9%) cases attributed to cardiovascular disease. Multivariate Cox regression analysis showed that lower levels of LDL-C were associated with a higher risk of all-cause and cardiovascular mortality; the LDL-C group’s lowest level (&lt;2.198 mmol/L) still showed a 19.6% increased risk of all-cause mortality (p = 0.0068) in the model that was completely adjusted. Both all-cause mortality and cardiovascular mortality showed a non-linear association with LDL-C concentration in restricted cubic spline regression analysis.ConclusionsIn individuals with hypertension, LDL-C was linked to cardiovascular and all-cause mortality. It was further demonstrated that this relationship was non-linear.
Association of frailty with cardiovascular and all-cause mortality in community-dwelling older adults: insights from the Chinese longitudinal healthy longevity survey
Authors: Gao Hui , Ma Qiaoli , Li Jiahai , Zhang Qinghui 
Published: December 2024

BackgroundPrevious studies suggest that frailty increases the risk of mortality, but the risk of cardiovascular disease (CVD) and all-cause mortality in Chinese community-dwelling older adults remains understudied. Our aim was to explore the effect of frailty on cardiovascular and all-cause mortality in older adults based on a large-scale prospective survey of community-dwelling older adults in China.MethodsWe utilized the 2014–2018 cohort of the Chinese Longitudinal Healthy Longevity Survey and constructed a frailty index (FI) to assess frailty status. Propensity score matching was used to equalize the baseline characteristics of participants to strengthen the reliability of the findings. Hazard ratios and 95% confidence intervals (CIs) were estimated using multivariate Cox models, adjusting for potential confounders, to assess the association between frailty and cardiovascular and all-cause mortality. The relationship between frailty and cardiovascular mortality was further explored using a competing risk model considering death as a competing event. The dose–response relationships between them were estimated using restricted cubic spline models.ResultsThe results of the multivariate Cox model found that the frailty group had a higher risk of CVD mortality (1.94, 95% CI: 1.43–2.63) and all-cause mortality (1.87, 95% CI: 1.63–2.14) in compared with the non-frailty group. The multivariate competing risks model suggested a higher risk of CVD mortality in the frailty group (1.94, 95% CI: 1.48–2.53). The analysis found no non-linear relationship between FI and the risk of CVD mortality but a non-linear dose–response relationship with the risk of all-cause mortality.ConclusionsFrail older adults demonstrated a stronger risk of CVD and all-cause mortality. Reversing frailty in older adults is therefore expected to reduce the risk of death in older adults.
Adaptability evaluation of the FIRST model in Hobq Desert, northern China
Authors: Zheng Xinqian , Yang Fan , Wang Jingshu , Xu Lishuai , Abudukade Silalan , Ma Mingjie , Sun Yingwei 
Published: December 2024

Obtaining high temporal and spatial resolution spectral data is the key to revealing the influencing factors, effects, and mechanisms of land-atmosphere interactions in deserts. This study, we used MODIS and Sentinel-2 data as data sources to calculate daily reflectance and Normalized Difference Vegetation Index (NDVI) data with a spatial resolution of 10 m, based on the Spatiotemporal Fusion Incorporating Spectral Autocorrelation (FIRST) model, across different climatic zones in the Hobq Desert, northern China, in March. Then, we evaluated the adaptability of the FIRST model in the Hobq Desert based on spatial and textural characteristics, as well as spatial-temporal distribution characteristics, using qualitative analysis, quantitative analysis, and geographic detectors. The results show that the correlation coefficients of First fused data and Sentinel-2 data in red, green, blue, near-infrared bands, and NDVI were 0.574 (p &lt; 0.01), 0.448 (p &lt; 0.01), 0.485 (p &lt; 0.01), 0.573 (p &lt; 0.01), and 0.625 (p &lt; 0.01), and the scatter points were evenly distributed on both sides of y = x. Meanwhile, FIRST NDVI and Sentinel-2 NDVI maintained consistency in spatial texture and hue changes, with similar value ranges. The daily scale coefficient of variation (CV) of FIRST NDVI in different desert types were less than that of MODIS NDVI. Among them, the variability of FIRST NDVI in fixed dunes was significantly smaller than that of MODIS NDVI, with the former’s CV being 0.034 smaller than the latter’s. Besides, it was found that there were significant differences in First NDVI among different desert types based on risk detection, while MODIS NDVI showed insignificant differences between fixed dunes and semi-fixed dunes. This suggests that First model integrated effectively various types of remote sensing data and had strong applicability in the eastern part of Hobq Desert, which could distinguish between fixed dunes and semi-fixed dunes, providing a more accurate monitoring tool for environmental zoning management in desert areas.