bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age, time from injury to surgery and hop performance after primary ACLR affect the risk of contralateral ACLR
Authors: Cristiani Riccardo , Forssblad Magnus , Edman Gunnar , Eriksson Karl , Stålman Anders 
Published: October 2021

Abstract
Purpose
To evaluate factors affecting the risk of contralateral anterior cruciate ligament reconstruction (ACLR) within 5 years of primary ACLR.

Methods
Primary ACLRs performed at Capio Artro Clinic, Stockholm, Sweden, during the period 2005–2014, were reviewed. The outcome of the study was the occurrence of contralateral ACLR within 5 years of primary ACLR. Univariable and multivariable logistic regression analyses were employed to identify preoperative [age, gender, body mass index (BMI), time from injury to surgery, pre-injury Tegner activity level], intraoperative [graft type, medial meniscus (MM) and lateral meniscus (LM) resection or repair, cartilage injury] and postoperative [limb symmetry index (LSI) for quadriceps and hamstring strength and single-leg-hop test performance at 6 months] risk factors for contralateral ACLR.

Results
A total of 5393 patients who underwent primary ACLR were included. The incidence of contralateral ACLR within 5 years was 4.7%. Univariable analysis revealed that age ≥ 25 years, BMI ≥ 25 kg/m2, time from injury to surgery ≥ 12 months and the presence of a cartilage injury reduced the odds, whereas female gender, pre-injury Tegner activity level ≥ 6, quadriceps and hamstring strength and a single-leg-hop test LSI of ≥ 90% increased the odds of contralateral ACLR. Multivariable analysis showed that the risk of contralateral ACLR was significantly affected only from age ≥ 25 years (OR 0.40; 95% CI 0.28–0.58; P < 0.001), time from injury to surgery ≥ 12 months (OR 0.48; 95% CI 0.30–0.75; P = 0.001) and a single-leg-hop test LSI of ≥ 90% (OR 1.56; 95% CI 1.04–2.34; P = 0.03).

Conclusion
Older age (≥ 25 years) and delayed primary ACLR (≥ 12 months) reduced the odds, whereas a symmetrical (LSI ≥ 90%) 6-month single-leg-hop test increased the odds of contralateral ACLR within 5 years of primary ACLR. Knowledge of the factors affecting the risk of contralateral ACLR is important when it comes to the appropriate counselling for primary ACLR. Patients should be advised regarding factors affecting the risk of contralateral ACLR.

Level of evidence
Level III.
Characterisation of contact twinning for cerussite, $$\hbox {PbCO}_3$$, by single-crystal NMR spectroscopy
Authors: Zeman Otto E. O. , Steinadler Jennifer , Hochleitner Rupert , Bräuniger Thomas 
Published: October 2021

AbstractCerussite, $$\hbox {PbCO}_3$$

PbCO
3

, like all members of the aragonite group, shows a tendency to form twins, due to high pseudo-symmetry within the crystal structure. We here demonstrate that the twin law of a cerussite contact twin may be established using only $$^{207}$$

207

Pb-NMR spectroscopy. This is achieved by a global fit of several sets of orientation-dependent spectra acquired from the twin specimen, allowing to determine the relative orientation of the twin domains. Also, the full $$^{207}$$

207

Pb chemical shift tensor in cerussite at room temperature is determined from these data, with the eigenvalues being $$\delta _{11} = (-2315\pm 1)$$

δ
11

=

(
-
2315
±
1
)

ppm, $$\delta _{22} = (-2492 \pm 3)$$

δ
22

=

(
-
2492
±
3
)

ppm, and $$\delta _{33} = (-3071 \pm 3)$$

δ
33

=

(
-
3071
±
3
)

ppm.
Phase I/II study to assess the clinical pharmacology and safety of single ascending and multiple subcutaneous doses of PF-06881894 in women with non-distantly metastatic breast cancer
Authors: Yao Hsuan-Ming , Jones Sarah Ruta , Morales Serafin , Moosavi Shahrzad , Zhang Jeffrey , Freyman Amy , Ottery Faith D. 
Published: October 2021

Abstract
Purpose
To evaluate the pharmacodynamics (PD), pharmacokinetics (PK), and safety of single and multiple doses of PF-06881894 (pegfilgrastim-apgf; Nyvepria™), a biosimilar to reference pegfilgrastim (Neulasta®), in women with non-distantly metastatic breast cancer.

Methods
In Phase I (Cycle 0) of this Phase I/II study, the PD response (absolute neutrophil count [ANC]; CD34 + count), PK profile, and safety of a single 3- or 6-mg subcutaneous dose of PF-06881894 were assessed in chemotherapy-naïve patients before definitive breast surgery. In Phase II (Cycles 1–4), the PD response (duration of severe neutropenia [DSN, Cycle 1], ANC [Cycles 1 and 4]) and PK profile (Cycles 1 and 4) of single and multiple 6-mg doses of PF-06881894 concomitant with chemotherapy and after definitive breast surgery were assessed.

Results
Twenty-five patients (mean age 59 years) were enrolled (Cycle 0, n = 12; Cycles 1–4, n = 13). In Cycle 0, PD responses and PK values were lower with 3-mg versus 6-mg PF-06881894. In Cycles 1 and 4, mean DSN was 0.667 days after single or multiple 6-mg doses of PF-06881894, respectively. In Cycle 4 versus Cycle 1, PD responses were more robust; PK values (mean area under the curve, maximum concentration) were lower; and clearance values were higher. The safety profile of PF-06881894 was similar to that for reference pegfilgrastim.

Conclusion
PF-06881894 as a single 3- or 6-mg dose prior to definitive surgery, or multiple 6-mg/cycle doses postoperatively, with/without myelosuppressive chemotherapy, was consistent with the clinical pharmacology and safety profile of reference pegfilgrastim.

Trial registration
October 2017. ClinicalTrials.gov Identifier: NCT02650193. EudraCT Number: 2015-002057-35.
Co-clustering of Time-Dependent Data via the Shape Invariant Model
Authors: Casa Alessandro , Bouveyron Charles , Erosheva Elena , Menardi Giovanna 
Published: October 2021

AbstractMultivariate time-dependent data, where multiple features are observed over time for a set of individuals, are increasingly widespread in many application domains. To model these data, we need to account for relations among both time instants and variables and, at the same time, for subject heterogeneity. We propose a new co-clustering methodology for grouping individuals and variables simultaneously, designed to handle both functional and longitudinal data. Our approach borrows some concepts from thecurve registrationframework by embedding theshape invariant modelin thelatent block model, estimated via a suitable modification of the SEM-Gibbs algorithm. The resulting procedure allows for several user-defined specifications of the notion of cluster that can be chosen on substantive grounds and provides parsimonious summaries of complex time-dependent data by partitioning data matrices into homogeneous blocks. Along with the explicit modelling of time evolution, these aspects allow for an easy interpretation of the clusters, from which also low-dimensional settings may benefit.
Künstliche Intelligenz-unterstützte Behandlung in der Rheumatologie
Authors: Hügle Thomas , Kalweit Maria 
Published: October 2021

ZusammenfassungComputergesteuerte klinische Entscheidungssysteme finden seit Längerem Einzug in die Praxis. Deren primäre Ziele sind die Verbesserung der Behandlungsqualität, Zeitersparnis oder Fehlervermeidung. Meist handelt es sich um regelbasierte Algorithmen, die in elektronische Patientenakten integriert werden, z. B. um Medikamenteninteraktionen zu erkennen. Durch künstliche Intelligenz (KI) können klinische Entscheidungssysteme disruptiv weiterentwickelt werden. Aus Daten wird durch maschinelles Lernen konstant neues Wissen geschaffen, um individuelle Krankheitsverläufe bei Patienten vorherzusagen, Probleme schneller zu erkennen, Phänotypen zu identifizieren oder die Therapieentscheidung zu unterstützen. Solche Algorithmen für rheumatologische Erkrankungen gibt es bereits. Am weitesten fortgeschritten hierbei sind die automatisierte Bilderkennung sowie Vorhersagen zum Krankheitsverlauf bei der rheumatoiden Arthritis. Von nutzerfreundlichen, durch Schnittstellen vernetzten KI-Entscheidungssystemen kann aber noch nicht gesprochen werden. Zudem sind die Algorithmen oft noch nicht genügend validiert und reproduzierbar. Anstatt die KI-unterstützte Wahl der Behandlung dem Arzt oder der Ärztin vorzugeben, wird KI eher als hybride Entscheidungsunterstützung dienen – immer unter Einbezug sowohl des Experten als auch des Patienten. Es gibt zudem ein großes Bedürfnis nach Sicherheit durch nachvollziehbare und auditierbare Algorithmen, um die Qualität und Transparenz von KI-unterstützten Therapieempfehlungen nachhaltig zu gewährleisten.
Telemedizinische Betreuung und IT-gestützte Verfahren in der Rheumatologie
Authors: McCutchan Rick , Bosch Philipp 
Published: October 2021

Zusammenfassung
Hintergrund
Die COVID-19-Pandemie, aber auch die immer größere werdende Beanspruchung des Gesundheitssystems führen dazu, dass die Weiterentwicklung von telemedizinischen Angeboten auch in der Rheumatologie in den Vordergrund gerückt ist.

Fragestellung
Welche Evidenz existiert zu telemedizinischen Angeboten in der Rheumatologie?

Material und Methode
Es erfolgt ein narrativer Review zu bestehenden Arbeiten über Telemedizin in der Rheumatologie.

Ergebnisse
Elektronische „patient reported outcomes“ (ePROs) können von PatientInnen von zu Hause aus bestimmt und dem betreuenden Rheumatologen elektronisch geschickt werden. ePROs könnten in Zukunft dabei helfen zu entscheiden, wann eine klinische Visite notwendig ist. Telemedizinische Visiten wurden bereits durchgeführt bei gut eingestellten PatientInnen mit rheumatischen Erkrankungen mit guten Ergebnissen hinsichtlich Sicherheit und Krankheitsverlauf im Vergleich zu konventionellen Face-to-face-Visiten. Telemedizinische Visiten stellen ein interessantes Tool für Terminpriorisierung und Triage dar, wobei automatisierte, algorithmusbasierte Applikationen derzeit für die klinische Routine noch zu ungenau sind. Die Rolle von Smartphone-Applikationen in der Betreuung von PatientInnen mit rheumatischen Erkrankungen ist noch unklar.

Diskussion
Telemedizin stellt eine interessante Option für bestimmte PatientInnengruppen mit rheumatischen Erkrankungen dar. Abgesehen von Forschung an Effektivität und Sicherheit telemedizinischer Maßnahmen, müssen Entscheidungsträger klare Regeln vorgeben, wie Telemedizin eingesetzt werden soll, um dem individuellen Patienten die bestmögliche Behandlung zukommen zu lassen.
Apps in der Rheumatologie
Authors: Strunz Patrick-Pascal , Maire Maxime Le , Heusinger Tobias , Hammel Ludwig , Gernert Michael , Schwaneck Eva C. , Callhoff Johanna , Portegys Jan , Schmalzing Marc , Tony Hans-Peter , Froehlich Matthias 
Published: October 2021

Zusammenfassung
Hintergrund
Digitale Gesundheitsanwendungen (DiGA) halten in vielen Bereichen der Medizin Einzug und haben das Potenzial, die Patientenversorgung zu revolutionieren. In der Rheumatologie wäre der Einsatz bei der axialen Spondyloarthritis (axSpA) in Form einer Trainings- und Bewegungs-App denkbar. In einer repräsentativen Umfrage unter Patienten mit axSpA sollte daher ermittelt werden, ob eine solche App aktuell benötigt wird.

Methodik
Durchführung einer anonymen Onlinebefragung bei axSpA-Patienten der Deutschen Vereinigung Morbus Bechterew e. V. mittels eines Fragebogens; Datenauswertung mittels Excel und GraphPad Prism.

Ergebnisse
Es nahmen 435 axSpA-Patienten an der Befragung teil. Von den Befragten sehen 84 % die Entwicklung einer speziell auf axSpA abgestimmten Bewegungs-App als notwendig an und genauso viele wollen diese auch nutzen. Patienten unter 60 Jahre, Patienten unter 60-Jahre mit Biologika- oder Januskinase-Inhibitor-Therapie und Patienten mit häufigen Rückenschmerzen geben im Vergleich zur jeweiligen Kontrollsubgruppe einen höheren Bedarf an (jeweils p < 0,001).

Schlussfolgerung
Die Entwicklung einer Bewegungs-App für die axSpA wird von einem Großteil der Betroffenen als notwendig angesehen, wobei jüngere und intensiver medikamentös therapierte Patienten einen höheren Bedarf zu haben scheinen.
Prostatic tissue: an unexpected finding in a mature ovarian teratoma
Authors: Pecorella Irene , Framarino dei Malatesta Maria Luisa , Riganelli Lucia , Ciardi Gaia , Porpora Maria Grazia 
Published: October 2021

Abstract
Purpose
Prostatic
tissue in an ovarian teratoma is an unusual finding, whose initiation in a 46, XX karyotype tissue is yet to be clarified. We present a case from our files and review the literature for this intriguing finding.

Methods
Unstained histology sections of the ovarian teratoma containing prostatic tissue were evaluated using immunohistochemistry for PSA and androgen receptor.

Results
Both PSA and androgen receptor immunostainings were positive in the prostatic tissue. From the literature review, it appears that most of the patients (74%) with similar findings were either pregnant or experiencing a miscarriage, menopausal or infertile at presentation, showing that an imbalanced hormone status is frequently associated with the presence of male structures in ovarian teratomas.
Splenorenal shunt for reconstruction of the gastric and splenic venous drainage during pancreatoduodenectomy with resection of the portal venous confluence
Authors: Al-Saeedi Mohammed , Frank-Moldzio Leonie , Contin Pietro , Mayer Philipp , Loos Martin , Schmidt Thomas , Schneider Martin , Müller-Stich Beat P. , Berchtold Christoph , Mehrabi Arianeb , Hackert Thilo , Büchler Markus W. , Strobel Oliver 
Published: October 2021

Abstract

Background

Resection of the portal venous confluence is frequently necessary for radical resection during pancreatoduodenectomy for cancer. However, ligation of the splenic vein can cause serious postoperative complications such as gastric/splenic venous congestion and left-sided portal hypertension. A splenorenal shunt (SRS) can maintain gastric and splenic venous drainage and mitigate these complications.

Purpose

This study describes the surgical technique, postoperative course, and surgical outcomes of SRS after pancreatoduodenectomy.

Methods
Ten patients who underwent pancreatoduodenectomy and SRS between September 2017 and April 2019 were evaluated. After resection an end-to-side anastomosis between the splenic vein and the left renal vein was performed. Postoperative shunt patency, splenic volume, and any SRS-related complications were recorded.

Results
The rates of short- and long-term shunt patency were 100% and 60%, respectively. No procedure-associated complications were observed. No signs of left-sided portal hypertension, such as gastrointestinal bleeding or splenomegaly, and no gastric/splenic ischemia were observed in patients after SRS.

Conclusion
SRS is a safe and effective measure to mitigate gastric congestion and left-sided portal hypertension after pancreatoduodenectomy with compromised gastric venous drainage after resection of the portal venous confluence.
Effects of ambient temperature during the nestling stage on a stress indicator in nestling pied flycatchers Ficedula hypoleuca
Authors: Skwarska Joanna , Podstawczyńska Agnieszka , Bańbura Mirosława , Glądalski Michał , Kaliński Adam , Markowski Marcin , Wawrzyniak Jarosław , Zieliński Piotr , Bańbura Jerzy 
Published: October 2021

AbstractLong-term and short-term changes in ambient temperature can cause stress in birds, leading to changes in the level of hematological parameters. The H:L ratio (heterophil-to-lymphocyte ratio) is a hematological index that allows for the assessment of the stress induced by environmental changes, including weather conditions. In this paper, we examined the influence of temperatures and the sum of precipitation on the health of nestling pied flycatchers (Ficedula hypoleuca) by using the H:L ratio reflecting the body’s response to stress. All examined temperature indicators influenced the H:L ratio, yet the average value of daily minimum temperature during the first 12 days of nestling life had the strongest influence, maximum temperature had the weakest effect, while precipitation had no significant influence. Our research indicates that even a small increase in temperature caused a stress reaction in nestling pied flycatchers, which was reflected by an increase in the H:L ratio. The increase in the stress index (H:L ratio) was probably a result of poor weather conditions (precipitation, low temperature), which prevented the adult birds from actively foraging and properly feeding the nestlings.
A machine learning-based clustering approach to diagnose multi-component degradation of aircraft fuel systems
Authors: Liu Haochen , Zhao Yifan , Zaporowska Anna , Skaf Zakwan 
Published: October 2021

AbstractAccurate fault diagnosis and prognosis can significantly reduce maintenance costs, increase the safety and availability of engineering systems that have become increasingly complex. It has been observed that very limited researches have been reported on fault diagnosis where multi-component degradation are presented. This is essentially a challenging Complex Systems problem where features multiple components interacting simultaneously and nonlinearly with each other and its environment on multiple levels. Even the degradation of a single component can lead to a misidentification of the fault severity level. This paper introduces a new test rig to simulate the multi-component degradation of the aircraft fuel system. A machine learning-based data analytical approach based on the classification of clustering features from both time and frequency domains is proposed. The scope of this framework is the identification of the location and severity of not only the system fault but also the multi-component degradation. The results illustrate that (a) the fault can be detected with accuracy > 99%; (b) the severity of fault can be identified with an accuracy of almost 100%; (c) the degradation level can be successfully identified with the R-square value > 0.9.
Solid-phase synthesis of imprinted nanoparticles as artificial antibodies against the C-terminus of the cannabinoid CB1 receptor: exploring a viable alternative for bioanalysis
Authors: Gómez-Caballero Alberto , Elejaga-Jimeno Ainhoa , García del Caño Gontzal , Unceta Nora , Guerreiro Antonio , Saumell-Esnaola Miquel , Sallés Joan , Goicolea M. Aránzazu , Barrio Ramón J. 
Published: October 2021

AbstractThe production of artificial anti-CB1 antibodies in nanoparticle format is described using the solid-phase imprinting approach. Instead of whole protein imprinting, a linear C-terminus sequence of the receptor comprising 15 amino acids (458-KVTMSVSTDTSAEAL-472) has been used as template, in accordance with the epitope imprinting approach. This sequence is located intracellularly, and it is involved in coupling to Gi/o proteins, being responsible for CB1 receptor desensitisation and internalisation. Developed molecularly imprinted materials were found to be in the nanometre scale, with a particle size of 126.4 ± 10.5 nm at pH 3 (25 ºC) and spherical shape. It was also observed that the size was sensible to temperature changes being reduced to 106.3 ± 15.2 nm at 35 °C. Lower critical solution temperature of this polymer was found to be ≈ 33.4 °C. The affinity and selectivity of the artificial antibody were assessed through dot blot and Western blot experiments. For the latter, recombinant fusion proteins GST-CB1414-472 and GST-CB1414-442 were produced to work respectively as target and negative control proteins. The control protein did not carry the target epitope for being devoid of last 30 amino acids at the C-terminus. The results demonstrated that the anti-CB1 material recognised selectively the target protein, thanks to the presence of the 15-amino acid sequence selected as epitope, which revealed that binding occurred at the C-terminus of the receptor itself. The methodology presented may pave the way for the development of novel imprinted nanomaterials for other proteins included in the superfamily of the G-protein-coupled receptors (GPCR).
Graphical abstract
A historical review of multiple system atrophy with a critical appraisal of cellular and animal models
Authors: Marmion David J. , Peelaerts Wouter , Kordower Jeffrey H. 
Published: October 2021

AbstractMultiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by striatonigral degeneration (SND), olivopontocerebellar atrophy (OPCA), and dysautonomia with cerebellar ataxia or parkinsonian motor features. Isolated autonomic dysfunction with predominant genitourinary dysfunction and orthostatic hypotension and REM sleep behavior disorder are common characteristics of a prodromal phase, which may occur years prior to motor-symptom onset. MSA is a unique synucleinopathy, in which alpha-synuclein (aSyn) accumulates and forms insoluble inclusions in the cytoplasm of oligodendrocytes, termed glial cytoplasmic inclusions (GCIs). The origin of, and precise mechanism by which aSyn accumulates in MSA are unknown, and, therefore, disease-modifying therapies to halt or slow the progression of MSA are currently unavailable. For these reasons, much focus in the field is concerned with deciphering the complex neuropathological mechanisms by which MSA begins and progresses through the course of the disease. This review focuses on the history, etiopathogenesis, neuropathology, as well as cell and animal models of MSA.
The association between coffee consumption and periodontitis: a cross-sectional study of a northern German population
Authors: Struppek Julia , Walther Carolin , Bunte Kübra , Zyriax Birgit-Christiane , Wenzel Jan-Per , Senftinger Juliana , Nikorowitsch Julius , Heydecke Guido , Seedorf Udo , Beikler Thomas , Borof Katrin , Mayer Carola , Aarabi Ghazal 
Published: October 2021

Abstract
Background
Positive and negative influences on oral health are attributed to coffee consumption. The aim of the current study is to evaluate the association between coffee consumption and periodontitis in the general population of Hamburg.

Methods
A total of 6,209 participants from the Hamburg City Health Study were included in this cross-sectional study. Information on coffee consumption was collected using a food frequency questionnaire. Periodontal examination included assessment of dental care ability via Plaque Index, measurement of pocket depth, gingival recession, and bleeding on probing. Classification was based on the criteria of Eke and Page. Ordinal logistic regression models were performed unadjusted and adjusted for confounding variables.

Results
Periodontal cohort consists of 6,209 participants, presenting either none/mild (n = 1,453, 39.6% men, 2.4% strong coffee drinkers), moderate (n = 3,580, 49.3% men, 3.3% strong coffee drinkers), or severe (n = 1,176, 60.9% men, 5.0% strong coffee drinkers) periodontitis. There was a significant association between strong coffee consumption (≥ 7or more cups/day) and periodontitis (OR: 1.51; CI: 1.07, 2.12; p > 0.001), compared with low coffee consumption. Conversely, moderate coffee consumption was not associated with periodontitis, compared with low coffee consumption.

Conclusion
and clinical relevance.
In this cross-sectional study of a northern German population, strong coffee consumption was significantly associated with periodontitis. Influence of changes in coffee consumption on periodontal disease etiology/progression should be investigated in future prospective study designs, in order to identify strong coffee consumption as a potential risk factor of periodontitis.