bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anesthesia Management of Congenital Diaphragmatic Hernia in Neonates
Authors: Pranata Harry , Kurniyanta Putu 
Published: February 2021

Abstract
Congenital diaphragmatic hernia (CDH) is an emergency case in neonates. The prevalence of CDH is 1 in 2500 births and occurs 4–8 times more commonly on left side than right side. CDH is usually worsened by pulmonary hypoplasia and pulmonary hypertension. It is characterized by respiratory failure and bowel sound in the chest area and mostly requires surgical procedure. This case report discusses a neonate with congenital left diaphragmatic hernia who underwent surgical procedure to close the defect. Patients present with cyanosis and shortness of breath, are early intubated, and are mechanically ventilated in neonatal intensive care unit (NICU). In the present case, the surgical procedure lasted approximately 2 h with general anesthesia, with hemodynamic stability during the surgery. The patient was thereafter intubated and treated at the NICU for close monitoring.
Audit of principal investigator's compliance for submission of continue review application and decisions taken on lapses in validity of approval by the Institutional Ethics Committee at tertiary oncology center in Navi Mumbai
Authors: Bandekar Bhavesh , Awatagiri Kasturi , Kannan Sadhana , Rane Pallavi , Parikh Prafulla 
Published: February 2021

Context:
A failure to obtain continued Institutional Ethics Committee (IEC) approval for the study before the expiry date assigned by the IEC is considered as “lapse of the IEC approval” to continue the study at the site by the Investigator. Considering this, we had conducted an audit of principal investigators (PI ') compliance for Continuing Review Application (CRA) submission timelines and decision taken on the lapses in the validity of IEC approval continuation.

Aim:
The aim of this study is to assess the pre- and post-policy trends of non-compliance management of delayed CRA submission and compare the PI's compliance for submission of CRA between Investigator Initiated trial (IIT) and Pharma studies.

Setting and Design:
The present study was a retrospective audit of CRAs of ongoing projects submitted by PIs to IEC, ACTREC.

Materials and Methods:
The data from total 199 CRAs submitted for review to the IEC between the year January 2016 and December-2017 were collected and maintained in Microsoft Excel sheet, and later, the data were exported into the SPSS software version 21 for the analysis.

Statistical Analysis:
All categorical data were presented in numbers and percentage. The first primary objective was assessed by calculating the duration between the dates of approval for any study to the date of next CRA submission. The CRAs submitted after the project expiry date were considered as a lapse in following the IEC SOP.

Results:
This retrospective audit revealed that CRA reminder sent by the IEC to the PI played an important role in compliance w. r. t timely in following the IEC SOPof the CRA by the PI. As a result, overall, 90% of CRAs showed compliance in submitting CRAs to IEC in both IIT and Pharma study. The number of lapses were reduced to 7 in the postpolicy period as compared to 15 lapses in the prepolicy period.

Conclusion:
This retrospective audit reveals that CRA reminder sent by the IEC to the PI played an important role in improving the compliance of PIs in submitting CRA to IEC. Each IEC should develop the policy to minimize the delays in CRA submission by the PI and prevent lapses in following the IEC SOP.
Chemoprotective Antimalarial Activity of P218 against Plasmodium falciparum: A Randomized, Placebo-Controlled Volunteer Infection Study
Authors: Chughlay Mohamed Farouk , El Gaaloul Myriam , Donini Cristina , Campo Brice , Berghmans Pieter-Jan , Lucardie Alexander , Marx Michael W. , Cherkaoui-Rbati Mohammed H. , Langdon Grant , Angulo-Barturen Iñigo , Viera Sara , Rosanas-Urgell Anna , Van Geertruyden Jean-Pierre , Chalon Stephan 
Published: February 2021

ABSTRACTP218 is a highly selective dihydrofolate reductase inhibitor with potent in vitro activity against pyrimethamine-resistant Plasmodium falciparum. This single-center, randomized, double-blind, placebo-controlled phase Ib study evaluated P218 safety, pharmacokinetics, and chemoprotective efficacy in a P. falciparum sporozoite (PfSPZ) volunteer infection study (VIS). Consecutive dose safety and tolerability were evaluated (cohort 1), with participants receiving two oral doses of P218 1,000 mg 48 hours apart (n = 6), or placebo (n = 2). P218 chemoprotective efficacy was assessed (cohorts 2 and 3) with direct venous inoculation of 3,200 aseptic, cryopreserved PfSPZ (NF54 strain) followed 2 hours later with two P218 doses of 1,000 mg (cohort 2, n = 9) or 100 mg (cohort 3, n = 9) administered 48 hours apart, or placebo (n = 6). Parasitemia was assessed from day 7 using quantitative PCR targeting the var gene acidic terminal sequence (varATS qPCR). By day 28, all participants in cohort 2 (P218 1,000 mg) and 8/9 in cohort 3 (P218 100 mg) were sterilely protected post-PfSPZ VIS, confirming P218 P. falciparum chemoprotective activity. With placebo, all six participants became parasitemic (geometric mean time to positive parasitemia 10.6 days [90% CI: 9.9–11.4]). P218 pharmacokinetics were similar in participants with or without induced infection. Adverse events of any cause occurred in 45.8% (11/24) of participants who received P218 and 50.0% (4/8) following placebo; all were mild/moderate in severity, transient, and self-limiting. There were no clinically relevant changes in laboratory parameters, vital signs, or electrocardiograms. P218 displayed excellent chemoprotective efficacy against P. falciparum with favorable safety and tolerability.
Diversité végétale et usages des plantes dans une zone de savane soudanienne : Cas de la localité de Ferkessédougou (Nord, Côte d'Ivoire)
Authors: Cisse Abdoulaye , Ouattara Mevanly , N’guessan Estelle Anny , Abrou Joël Emmanuel N’Gouan 
Published: February 2021

En Côte d’Ivoire, principalement dans le nord, on observe la présence de plusieurs formations végétales très variées allant des forêts claires et aux différents faciès de savanes. Dans la localité de Ferkessédougou, une étude a été menée dans le but de connaître la flore, la végétation et de l’usage des plantes. Cette étude a permis de recenser 192 espèces de végétales. Elles se répartissent en 148 genres et 64 familles. Parmi ces espèces, certaines ont été identifiées comme alimentaires, médicinales ou à divers autres usages. Aussi, vingt sont considérées comme des espèces ayant un statut particulier et qui nécessite une attention particulière en vue de leur protection ainsi que les habitats où elles se rencontrent. La présence de ces espèces peut constituer des indicateurs clés pour le suivi environnemental de la zone d’étude.Mots clés : Diversité végétale, Services écosystémiques, savane soudanienne, Ferkessédougou, Côte d’Ivoire.

English Title: Plant diversity and plant uses in a Sudanese savannah area: Case of the locality of Ferkessédougou (North, Côte d'Ivoire)In Ivory Coast, mainly in the north, we observe the presence of several very varied plant vegetations anging from open forests to different facies of savannah. In the locality of Ferkessédougou, a study was carried out to learn about the flora, vegetation and the use of plants. This study identified 192 species of plants. They are divided into 148 genera and 64 families. Among these species, some have been identified as food, medicinal or various other uses. Also, twenty are considered to be species with a special status and which requires very special attention for their protection as well as the habitats where they occur. The presence of these species can constitute key indicators for the environmental monitoring of the study area.
Keywords: Plant diversity, Ecosystem services, Sudanese savannah, Ferkessédougou, Ivory Coast.
Tax Appeal Proceedings before the Federal Tax Appeal Commission in Ethiopia: Critical Reflections
Authors: Byness Aschalew Ashagre 
Published: February 2021

Under the 2016 Federal Tax Administration Proclamation (FTAP), it is by way of appeal that taxpayers reach the judiciary when they can show that the Federal Tax Appeal Commission (FTAC) has committed an error of law. As far as factual issues are concerned, the decision of the FTAC is thus final and conclusive. Ethiopia’s tax dispute resolution system has made improvements although there has been discontent on the part of taxpayers. This article examines the tax appeal processes at the federal level to see whether the processes enhance fair play between taxpayers and the tax authority. Specifically, the article evaluates whether there are clear and adequate procedural rules that ensure access to justice for aggrieved taxpayers and fair treatment by the Federal Tax Appeal Commission (FTAC). I argue that although there have been certain improvements made by the FTAP (as far as administrative appeal before the FTAC is concerned), there are still some critical shortcomings that have to be reconsidered.
AfCFTA’s Notification Options to WTO: Enabling Clause or Article XXIV Exception
Authors: Tegegn Yehualashet Tamiru 
Published: February 2021

Since the formation of the Organization of African Unity (OAU), African countries envisage regional integration to enhance trade among themselves. This effort was preceded by the formation of the sub-regional economic groups which serve as building blocks towards a larger integration. Africa Continental Free Trade Agreement (hereinafter AfCFTA) came into force in May 2019. As per the procedural requirements of the WTO, AfCFTA should be notified either to WTO’s Committee on Trade and Development (CTD) if AfCFTA opts to use enabling clause exception; or it should be notified to the Committee on Regional Trade Agreement if AfCFTA opts to use Article XXIV of GATT/WTO exception. This comment examines under which exception AfCFTA should notify its integration. I argue that it is better for AfCFTA to notify its integration under Article XXIV of GATT/WTO to the Committee on Regional Trade Agreement rather than under enabling clause to the Committee on Trade and Development.
Bridgeland Stability Conditions on Fano Threefolds
Authors: Bernardara Marcello , Macrì Emanuele , Schmidt Benjamin , Zhao Xiaolei 
Published: February 2021

We show the existence of Bridgeland stability conditions on all Fano threefolds, by proving a modified version of a conjecture by Bayer, Toda, and the second author. The key technical ingredient is a strong Bogomolov inequality, proved recently by Chunyi Li. Additionally, we prove the original conjecture for some toric threefolds by using the toric Frobenius morphism.Comment: 24 pages, 1 figure. Fifth version: Official version of the journal
Smoothing cones over K3 surfaces
Authors: Coughlan Stephen , Sano Taro 
Published: February 2021

We prove that the affine cone over a general primitively polarised K3 surface of genus g is smoothable if and only if g ≤ 10 or g = 12. We also give several examples of singularities with special behaviour, such as surfaces whose affine cone is smoothable even though the projective cone is not.Nous montrons que le cône affine sur une surface K3 primitivement polarisée générale de genre g est lissable si et seulement si g≤ 10 ou g = 12. Nous exhibons également plusieurs exemples de singularités affichant des comportements spécifiques, tels que des surfaces dont le cône affine est lissable alors même que le cône projectif ne l'est pas.
Algebraic models of the Euclidean plane
Authors: Blanc Jérémy , Dubouloz Adrien 
Published: February 2021

We introduce a new invariant, the real (logarithmic)-Kodaira dimension, that allows to distinguish smooth real algebraic surfaces up to birational diffeomorphism. As an application, we construct infinite families of smooth rational real algebraic surfaces with trivial homology groups, whose real loci are diffeomorphic to $\mathbb{R}^2$, but which are pairwise not birationally diffeomorphic. There are thus infinitely many non-trivial models of the euclidean plane, contrary to the compact case.Comment: 16 pages
Socle pairings on tautological rings
Authors: Janda Felix , Pixton Aaron 
Published: February 2021

We study some aspects of the $\lambda_g$ pairing on the tautological ring of $M_g^c$, the moduli space of genus $g$ stable curves of compact type. We consider pairing kappa classes with pure boundary strata, all tautological classes supported on the boundary, or the full tautological ring. We prove that the rank of this restricted pairing is equal in the first two cases and has an explicit formula in terms of partitions, while in the last case the rank increases by precisely the rank of the $\lambda_g\lambda_{g - 1}$ pairing on the tautological ring of $M_g$.Comment: 18 pages, 1 figure; v3: journal version; v2: minor revisions to sections 1.1 and 4.1, results unchanged
Higher rank sheaves on threefolds and functional equations
Authors: Gholampour Amin , Kool Martijn 
Published: February 2021

We consider the moduli space of stable torsion free sheaves of any rank on a smooth projective threefold. The singularity set of a torsion free sheaf is the locus where the sheaf is not locally free. On a threefold it has dimension $\leq 1$. We consider the open subset of moduli space consisting of sheaves with empty or 0-dimensional singularity set. For fixed Chern classes $c_1,c_2$ and summing over $c_3$, we show that the generating function of topological Euler characteristics of these open subsets equals a power of the MacMahon function times a Laurent polynomial. This Laurent polynomial is invariant under $q \leftrightarrow q^{-1}$ (upon replacing $c_1 \leftrightarrow -c_1$). For some choices of $c_1,c_2$ these open subsets equal the entire moduli space. The proof involves wall-crossing from Quot schemes of a higher rank reflexive sheaf to a sublocus of the space of Pandharipande-Thomas pairs. We interpret this sublocus in terms of the singularities of the reflexive sheaf.Comment: 29 pages. Published version
Smooth affine group schemes over the dual numbers
Authors: ROMAGNY Matthieu , Tossici Dajano 
Published: February 2021

We provide an equivalence between the category of affine, smooth group schemes over the ring of generalized dual numbers $k[I]$, and the category of extensions of the form $1 \to \text{Lie}(G, I) \to E \to G \to 1$ where G is an affine, smooth group scheme over k. Here k is an arbitrary commutative ring and $k[I] = k \oplus I$ with $I^2 = 0$. The equivalence is given by Weil restriction, and we provide a quasi-inverse which we call Weil extension. It is compatible with the exact structures and the $\mathbb{O}_k$-module stack structures on both categories. Our constructions rely on the use of the group algebra scheme of an affine group scheme; we introduce this object and establish its main properties. As an application, we establish a Dieudonné classification for smooth, commutative, unipotent group schemes over $k[I]$.Nous construisons une équivalence entre la catégorie des schémas en groupes affines et lisses sur l'anneau des nombres duaux généralisés k[I], et la catégorie des extensions de la forme 1 → Lie(G, I) → E → G → 1 où G est un schéma en groupes affine, lisse sur k. Ici k est un anneau commutatif arbitraire et k[I] = k ⊕ I avec I 2 = 0. L'équivalence est donnée par la restriction de Weil, et nous construisons un foncteur quasi-inverse explicite que nous appelons extension de Weil. Ces foncteurs sont compatibles avec les structures exactes et avec les structures de champs en O k-modules des deux catégories. Nos constructions s'appuient sur le schéma en algèbres de groupe d'un schéma en groupes affines, que nous introduisons et dont nous donnons les propriétés principales. En application, nous donnons une classification de Dieudonné pour les schémas en groupes commutatifs, lisses, unipotents sur k[I] lorsque k est un corps parfait.
Weighted Projective Lines and Rational Surface Singularities
Authors: Iyama Osamu , Wemyss Michael 
Published: February 2021

In this paper we study rational surface singularities R with star shaped dual graphs, and under very mild assumptions on the self-intersection numbers we give an explicit description of all their special Cohen-Macaulay modules. We do this by realising R as a certain Z-graded Veronese subring S^x of the homogeneous coordinate ring S of the Geigle-Lenzing weighted projective line X, and we realise the special CM modules as explicitly described summands of the canonical tilting bundle on X. We then give a second proof that these are special CM modules by comparing qgr S^x and coh X, and we also give a necessary and sufficient combinatorial criterion for these to be equivalent categories. In turn, we show that qgr S^x is equivalent to qgr of the reconstruction algebra, and that the degree zero piece of the reconstruction algebra coincides with Ringel's canonical algebra. This implies that the reconstruction algebra contains the canonical algebra, and furthermore its qgr category is derived equivalent to the canonical algebra, thus linking the reconstruction algebra of rational surface singularities to the canonical algebra of representation theory.Comment: Final version
Analisa Pendapatan Jasa Angkut Barang dan Beban Usaha Terhadap Laba Usaha pada BMT Darussalam
Authors: Zaelani Rizal , Ruswandi Wawan 
Published: February 2021

Penelitian dilakukan karena ada masalah mengenai analisa pendapatan jasa dan beban usaha terhadap laba usaha pada BMT DARUSSALAM selama periode 2019 yaitu sangat stabil.
Teknik analisis data yang digunakan dalam penelitian ini adalah dengan menggunakan metode expost facto merupakan penelitian yang bertujuan menemukan penyebab yang memungkinkan perubahan perilaku, gejala atau fenomena yang di sebabkan oleh suatu peristiwa, perilaku atau hal-hal yang menyebabkan perubahan pada variabel bebas yang secara keseluruhan sudah terjadi.
Hasil dari penelitian menunjukkan pendapatan jasa, beban usaha dan laba usaha cenderung stabil pada periode 2019 tidak ada kenaikan yang signifikan atau penurunan yang signifikan.
Implementasi Model MPI untuk Pengembangan Modul Mata Kuliah Analisis dan Desain Sistem Informasi di S1 Pendidikan Teknik Informatika UM
Authors: Aditya Muhammad , Wibawanto Slamet , Gunawan Gunawan 
Published: February 2021

Penelitian ini bertujuan untuk mengembangkan bahan ajar modul cetak pada mata kuliah ADSI di S1 Pendidikan Teknik Informatika UM dengan menerapkan kompetensi berdasarkan kurikulum Pendidikan Teknik Informatika UM tahun 2019. Pengembangan bahan ajar modul cetak dirasa tepat karena sesuai dengan karakterisik mahasiswa yang akan mengambil mata kuliah ADSI. Model penelitian dan pengembangan yang diterapkan adalah Model Pengembangan Instruksional (MPI). Model ini dipilih karena langkah pengembangannya lengkap namun fokus untuk mengembangkan bahan ajar hingga siap digunakan. Selain itu, model ini dipilih karena menyediakan rancangan urutan kegiatan pembelajaran yang sesuai dengan karakteristik mata kuliah ADSI. Teknik analisis data dilakukan dengan menggunakan teknik deskriptif kuantitatif. Hasil menunjukkan secara keseluruhan produk bahan ajar modul cetak yang dikembangkan mendapatkan persentase 88,15%, yang berarti sangat valid, atau sudah dapat digunakan
Pemetaan Prospek Pasar Wisatawan Nusantara di Indonesia
Authors: Maulana Addin 
Published: February 2021

Utilizing the Tourism Potential Market Matrix (PPP) which is a modification of the Boston Consulting Group (BCG) Matrix, this study resulted in a mapping of the prospects of the domestic tourist market in Indonesia. From this study, it was identified the market potential that besides on the ability of a provinces to produce the number of trips for domestic tourists, and also has the potential of the prospect of spending while traveling. There are 5 Provinces which are included in the most potential market quadrant in the development of domestic tourist because they have a high average income, and the high on travel propensity, namely: Bangka Belitung Islands, DKI Jakarta, Riau Islands, North Sulawesi and DI Yogyakarta. These provinces can be optimized by other provinces to be developed as a tourism market, so that they are expected to bring quality tourists.
Analisis Profil Wisatawan Mancanegara Yang Keluar Melalui Pintu Soekarno Hatta Dan Ngurah Rai
Authors: Juwita Hapsari Veronika , Nuryakin Chaikal 
Published: February 2021

Indonesia has enormous tourism potential. This potential is spread throughout almost all regions of Indonesia. However, until now Indonesian tourism is only synonymous with Bali. Development of other destinations besides Bali (non-Bali destinations) has begun to take place in almost all parts of Indonesia due to the economic potential of tourism which can drive the region's economy.
Although not as many as Bali, foreign tourists have visited non-Bali destinations. This proves that non-Bali destinations also have the potential to be developed due to tourism demand from tourists. This research aims to profile foreign tourists for non-Bali destinations as one of the steps in developing tourism marketing according to the National Tourism Development Master Plan 2010-2025.
In conclusion, tourists who visit non-Bali destinations are predominantly male and repeater
Karakteristik Wisatawan Nusantara yang Berkunjung ke Kota Solo
Authors: Nugroho Rizky 
Published: February 2021

Solo City located in Central Java Province with potential cultural tourism. Tourist objects in Solo City were varied from traditional, namely Kasunanan Solo Palace, to modern, such as Beteng Trade Center. Tourists are freely to visit those tourist objects and bought souvenirs that were easily to found around the city. This study aim to describe touristâ€™s characteristics who visited Solo City. The characteristics were divided into demographic aspect, physiologic aspect, and tourist trip pattern. Method used in this study was mixed and questionnaires were distributed among 100 respondents, then result was describe into preferred aspects. The results were clustered into specific aspects. Demographic aspect showed that most of the tourist was woman, aged between 15-24 years old, the majority of respondents were not civil servant or industrial labor, high school graduated, and not married. Physiologic aspect showed majority of respondents visited Solo City no more than 12 hours, and spend mostly on trip cost. Lastly, from tourist trip pattern, majority were traveled with non-family group, for holiday purposed, and arranged independently. Key words: characteristic, demographic, physiologic, tourism, trip
Dampak Pariwisata Terhadap Kondisi Sosial Budaya Masyarakat di Banda Aceh
Authors: Swesti Woro 
Published: February 2021

Various conditions are force the tourism development in Banda Aceh, one of them is tsunami wave in 2006. The condition of the people of Aceh who had been in a bad political and security with the presence of military operations and prolonged conflict, affected the way the Aceh community interacts with migrant (tourists). The study of the impact of tourism on socio-cultural is important to ensure that tourism development in Aceh does not disturb the sustainability of the socio-cultural aspects. The interaction between tourists and local people in Banda Aceh has a social and cultural impact. The socio-cultural impact of tourism development can be seen from the preservation of local culture such as traditional dances, Aceh's cultural history, preservation of various historic buildings in Aceh. While the negative impact of tourism on socio-cultural conditions can be seen from the response of local communities to the existence of tourism such as the emergence of conflicts of interest among stakeholders, and social problems such as gambling and prostitution. Some of part of the communities who think that tourism development is against Islamic law is become a challenge for tourism policy makers in Aceh. To anticipate this, it is necessary to change the strategy in developing tourism in Aceh. The community needs to be involved in determining policies and decisions related to tourism in their area.