bluuebunny/crossref_metadata_2025_split huggingface dataset:
Universal quantum phase transition from superconducting to insulating-like states in pressurized Bi2Sr2CaCu2O8+δ superconductors
Authors: Sun Liling , Zhou Yazhou , Guo Jing , Cai Shu , Zhao Jinyu , Gu Genda , Lin Chengtian , Yan Hongtao , Huang Cheng , Yang Chongli , Long Sijin , Gong Yu , Li Yanchun , Li Xiaodong , Wu Qi , Hu Jiangping , Zhou Xingjiang , Xiang Tao 
Published: June 2021

Abstract
Copper oxide superconductors have been continually fascinating the communities of condensed matter physics and material sciences because they host the highest ambient-pressure superconducting transition temperature ( T c ) and mysterious physics 1–3. Searching for the universal correlation between the superconducting state and its normal state or neighboring ground state is believed to be an effective way for finding clues to elucidate the underlying mechanism of the superconductivity. One of the common pictures for the copper oxide superconductors is that a well-behaved metallic phase will present after the superconductivity is entirely suppressed by chemical doping 4–8 or application of the magnetic field 9. Here, we report the first observation of universal quantum phase transition from superconducting state to insulating-like state under pressure in the under-, optimally- and over-doped Bi2Sr2CaCu2O8+δ (Bi2212) superconductors with two CuO2 planes in a unit cell. The same phenomenon has also been found in the Bi2Sr1.63La0.37CuO6+δ (Bi2201) superconductor with one CuO2 plane and the Bi2.1Sr1.9Ca2Cu3O10+δ (Bi2223) superconductor with three CuO2 planes in a unit cell. These results not only provide fresh information on the cuprate superconductors but also pose a new challenge for achieving unified understandings on the mechanism of the high-Tc superconductivity.
Development And Assessment Of Machine Learning Models For Predicting Recurrence Risk After Endovascular Treatment In Patients With Intracranial Aneurysms
Authors: Lin Shiteng , Zou Yang , Hu Jue , Xiang Lan , Guo Leheng , Lin Xinping , Zou Daizun , Gao Xiaoping , Liang Hui , Dai Xiaoming , Zhao ZhiHong , Zou JianJun 
Published: June 2021

Abstract
Intracranial aneurysms (IAs) remains a major public health concern and endovascular treatment (EVT) has become a major tool for managing IAs. However, the recurrence rate of IAs after EVT is relatively high, which may lead to the risk for aneurysm re-rupture and re-bleed. Thus, we aimed to develop and assess prediction models based on machine learning (ML) algorithms to predict recurrence risk among patients with IAs after EVT in 6 months. Patient population included patients with IAs after EVT between January 2016 and August 2019 in Hunan Provincial People's Hospital, and the data was randomly divided into a training set and a testing set. We developed five ML models and assessed the models. In addition, we used SHapley Additive exPlanations (SHAP) and local interpretable model-agnostic explanation (LIME) algorithms to determine the importance of the selected features and interpret the ML models. A total of 425 IAs were enrolled into this study, and 66 (15.5%) of which recurred in 6 months. Among the five ML models, gradient boosting decision tree (GBDT) model performed best. The area under curve (AUC) of the GBDT model on the testing set was 0.842 (sensitivity: 81.2%; specificity: 70.4%). Our study firstly demonstrated that ML-based models can serve as a reliable tool for predicting recurrence risk in patients with IAs after EVT in 6 months and the GBDT model showed the optimal prediction performance.
Interaction of Chemotherapy and Radiotherapy in Altering the Morphology of Subcortical Structures in Patients With Nasopharyngeal Carcinoma
Authors: Nan Feibiao , Zhang You-ming , Gao Jian-ming , Li Li , Zhang Yuanchao , Liao Wei-hua 
Published: June 2021

Abstract
Neuroimaging studies have found significant structural alterations of the cerebral cortex in patients with nasopharyngeal carcinoma (NPC) following radiotherapy (RT) or concomitant chemoradiotherapy (CCRT), while their effects on the morphology of subcortical structures remain largely unknown. In this study, we investigated the subcortical morphological alterations between three groups: 56 untreated NPC patients (pre-RT group), 37 RT-treated NPC patients (post-RT group), and 108 CCRT-treated NPC patients (post-CCRT group). Using FSL-FIRST, we found that, compared with the pre-RT group, the post-CCRT group exhibited morphological atrophy in the bilateral thalamus, bilateral putamen, left pallidum, and left caudate and morphological inflation in the left caudate, while the post-RT group only exhibited morphological atrophy in the bilateral thalamus. We also found a significant negative correlation between the maximum dosage of RT for temporal lobes and the morphological changes of the bilateral thalamus in treated NPC patients. These results indicated that there may be an interaction between RT and CT that can cause subcortical damage.
Sex Differences In The Association Between Hemoglobin A1c And Cerebral White Matter Lesions In The General Japanese Population
Authors: Li Honghao , Yu Jing , Guo Shougang 
Published: June 2021

Abstract
The influence of diabetes and associated sex differences on cerebral white matter lesions (WMLs) is unclear. We used data from a cross-sectional study uploaded to the DATADRYAD website by Shinkawa et al. to investigate differences in the association between hemoglobin A1c (HbA1c) levels and cerebral WMLs between men and women. The average age of all participants was56.4±11.5years old, and approximately 51.89 % of them were men. A linear relationship between HbA1c and cerebral WMLs was detected in men. Fully adjusted binary logistic regression showed no association of HbA1c with cerebral WMLs in men. A nonlinear relationship between HbA1c and cerebral WMLs was detected in women, whose cutoff point was 5.6%. The effect sizes and confidence intervals of the left and right sides of the inflection point were OR=0.21 (95%CI 0.06, 0.69, P=0.0098) and OR=3.5 (95%CI 1.50, 8.15, P=0.0037), respectively. In the higher HbA1c group, further subgroup analysis showed a stronger association between HbA1c and cerebral WMLs in women (OR=3.83, 95%CI 1.68, 8.72 P=0.0014) than in men (OR=1.02, 95%CI 0.76, 1.36 P=0.8986) (P for interaction with sex was 0.0004). A stronger effect of HbA1c on the risk of cerebral WMLs in women than in men was found in the higher HbA1c group.
Assessment of Spatiotemporal Variability and Rising Trends of Surface Ozone Over India
Authors: Kunchala Ravi Kumar , Singh Bhupendra Bahadur , Krishna Karumuri Rama , Attada Raju , Seelanki Vivek , Kumar Kondapalli Niranjan 
Published: June 2021

Abstract
With rising anthropogenic activities, surface ozone levels have increased across different parts of the world including India. Studies have shown that surface ozone shows distinct characteristics across India, however these studies are mostly based on isolated locations. Any comprehensive and spatiotemporally consistent study on surface ozone is lacking thus far. Keeping these facts in mind, we utilize ground-based observations and reanalysis datasets to investigate the surface ozone variability, seasonality, and linkages with meteorology over India. A validation exercise shows that the Copernicus Atmosphere Monitoring Service Reanalysis (CAMSRA) reasonably compares against the ground-based observations. Results show that the CAMSRA ozone is in good agreement with the observations across India, where it shows better correlations (r>0.7) over southern regions and relatively lesser (> 0.5) over northern and eastern regions indicating larger variability and spread over these regions. We further quantify this agreement in terms of range, mean absolute error (MAE), and root mean square error (RMSE). Time series analysis shows that the CAMSRA captures seasonal variations irrespective of location. Spatial distribution of surface ozone shows higher (lower) concentrations of about 40-60 ppb (15-20 ppb) during pre-monsoon (monsoon) months over a broad region covering northern and western parts, and peninsular India. A prominent increase during May is noted over the northern region especially over Indo-Gangetic Plains (IGP). These seasonal variations are linked to solar radiation (SR), temperature, low-level circulation, and boundary layer height (BLH). Furthermore, Principal Component Analysis (PCA) is performed to understand the dominant patterns of spatiotemporal variability for different seasons. It is seen that the first (second) mode shows a high percentage variance explained ranging between 30-50% (10-20%). The time series of PCA-1 mode indicates an overall increasing trend across India with a notable increase over south and central India. The second mode indicates prominent variability over the IGP (southern India) in the pre-monsoon (post-monsoon) season, which shows significant interannual variability. During the monsoon season, an interesting dipole pattern is seen which closely resembles the active and break spell patterns of the Indian summer monsoon. Overall, the spatiotemporal variations in surface ozone are closely tied to meteorology while the rising trends indicate the potential role of increasing precursors across India.
Geospatial Approach for Assessment of Groundwater Quality
Authors: Gauns Arvind Sharadchandra , Nagarajan M. , Lalitha R. , Baskar M. 
Published: June 2021

Abstract
Increasing population, erratic distribution of rainfall, and their rising demand for water in domestic and irrigation is fulfilled by groundwater resources. Due to overexploitation, there is the deterioration of groundwater quality and hence to evaluate the groundwater quality, a study was undertaken to understand the water suitability for drinking as well as for irrigation purposes. For this study, five villages namely Kumulur, Tachankurunchi, Pudurutamanur, Pandaravadai, and Poovalur were selected from Trichy District, Tamil Nadu, India with an areal extent of 45.1 km2. For the water quality assessment, samples were drawn from 53 locations from the sources like open well, bore well and hand pumps, etc., Parameters of pH, EC, TDS, Anions - CO3 2−, HCO3−, Cl−, SO4 2−, Cations - Ca2+, Mg2+, B3+, Na+ and potassium (K+) were estimated using the standard analytical procedure in three different seasons Viz., S-I (September 2019), S-II (December 2019) and S-III (March 2020). The WQI was computed for drinking water quality and it was found that 25% samples in S-I, 80% samples in S-II, and 83% samples in S-III were above the permissible limit for drinking purposes. Indices like Sodium Percentage, Sodium Adsorption Ratio, Permeability Index, Kelly’s Ratio, Magnesium Hazard Ratio, Potential Salinity, USSL Diagram, Wilcox Plot, Piper Diagram, and Gibbs plot were evaluated for examining irrigation water quality. The results revealed that 90% of the area, the water is suitable for irrigation purposes and a few locations (10%) wherein the salt content of water are relatively higher than the entire study area.
Stability of Fixed Points in an Approximate Solution of the Spring-mass Running Model
Authors: Wróblewska Zofia , Płociniczka Łukasz , Kowalczyk Piotr 
Published: June 2021

Abstract
We consider a classical spring-mass model of human running which is built upon an inverted elastic pendulum. Based on our previous results concerning asymptotic solutions for large spring constant (or small angle of attack), we construct analytical approximations of solutions in the considered model. The model itself consists of two sets of differential equations - one set describes the motion of the centre of mass of a runner in contact with the ground (support phase), and the second set describes the phase of no contact with the ground (flight phase). By appropriately concatenating asymptotic solutions for the two phases we are able to reduce the dynamics to a one-dimensional apex to apex return map. We find sufficient conditions for this map to have a unique stable fixed point. By numerical continuation of fixed points with respect to energy, we find a transcritical bifurcation in our model system.
Autologous Mesenchymal Stem Cell Therapy for Idiopathic Pulmonary Fibrosis and Comprehensive Assessment of Circulating Immune Populations Cells
Authors: Atanasova Elena , Milosevic Dragana , Bornschlegl Svetlana , Krucker Karen , Jacob Eapen , Porquera Eva Carmona , Anderson Dagny , Egan Ashley , Limper Andrew , Dietz Allan 
Published: June 2021

Abstract
BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic, progressive pulmonary disease characterized by aberrant tissue remodeling, formation of scar tissue within the lungs and continuous loss of lung function. The areas of fibrosis seen in lungs of IPF patients share many features with normal aging lung with cellular senescence being one. The contribution of the immune system to the etiology of IPF remains poorly understood. Evidence obtained from animal models and human studies suggests that innate and adaptive immune processes can orchestrate existing fibrotic responses. Currently, there is only modestly effective pharmacotherapy for IPF. Mesenchymal stem cells (MSCs)-based therapies have emerged as a potential option treatment of IPF. This study explores the possibility of using autologous MSCs as an IPF therapy and present an attempt to determine if the disease occurring in the lungs can be reflected on peripheral blood immune status. MethodsComprehensive characterization of autologous adipose derived MSCs (aMSCs) from five IPF patients and five age and gender matched Healthy Controls (HC) was done using flow cytometry, Droplet Digital PCR (ddPCR), Multiplex Luminex xMAP technology and confocal microscopy. For assessing the self renewal capacity and osteogenic differentiation IncuCyte Live Cell Imaging technology was used. Multi-parameter quantitative flow cytometry of un-manipulated whole blood of another group of 15 IPF patients and 87 (30 age and gender matched) HC was used to analyze 110 peripheral phenotypes.ResultsThere are no differences between autologous aMSCs from IPF patients and HC in their stem cell properties, self renewal capacity, plasticity for osteogenic differentiation, secretome content, cell cycle inhibitor marker levels and mitochondrial health. IPF patients had altered peripheral blood immunophenotype including reduced B cells subsets, increased T cell subsets, and increased granulocytes among others demonstrating clear and significant differences.ConclusionsOur results indicate that there is no difference in aMSCs properties from IPF patients and HC, suggesting that autologous aMSCs may be an acceptable option for IPF therapy.Characterization of peripheral immune phenotype may be a valuable indicator for successful therapy, and for potentially staging the disease.
MiR-582-3p Participates in the Regulation of Biological Behaviors of A549 Cells by Ambient PM2.5 Exposure
Authors: Ju Liangliang , Yang Mei , Li Changlian , Cheng Han , Li Na , Zhang Qi , Sun Shu , Ding Liu , Sui Xinmiao , Zhang Chao , Yang Mingwei , Cao Jiyu , Ding Rui 
Published: June 2021

Abstract
Background Ambient fine particulate matter (PM2.5) is one of the main environmental air pollutants that closely related to the development of lung cancer, but the mechanisms are unclear. Results In this study, A549 cells were exposed to ambient PM2.5 to investigate the alterations of biological behaviors, and the possible role of miR-582-3p in the effects was further explored. The findings showed that that PM2.5 exposure could significantly enhance the biological behaviors of A549 cells, and promote their EMT transformation, especially at relatively low doses. Over-activation of Wnt/β-catenin signaling pathway and increased expression of miR-582-3p were also found in A549 cells after PM2.5 exposure. After the knockdown of miR-582-3p in A549 cells, the effects of PM2.5 on malignant biological behavior changes, EMT and the activation of Wnt/β-catenin signaling pathway were all significantly alleviated. Furthermore, the inhibition of Wnt/β-catenin signaling pathway also inhibited the EMT process of A549 cells, which was rescued by the overexpression of miR-582-3p. Conclusion This study showed that ambient PM2.5 can up-regulate the expression of miR-582-3p, consequently activate the Wnt/β-catenin signaling pathway, thereby enhance EMT transformation and promote the malignant biological behaviors of A549 cells. These findings provide evidence for further research into the mechanisms by which exposure to PM2.5 in the environment promotes lung cancer.
Assessment on Environmental Quality Management of Coal Stockpile for Environmental Sustainability
Authors: Ambarita Novitasari , Juniah Restu , Syarifudin Syarifudin , Zakir Syaifudin , Rahmi Hisni 
Published: June 2021

Abstract
The positive impact of coal mining has been reported to increase the country's economy and community income. However, the negative impact is found to be reducing the physical and chemical parameters of air, noise, soil and spontaneous combustion quality, therefore, having the potential to decrease environmental quality. Environmental management is often carried out to improve the physical and chemical parameters of societal quality, in order to match the required standards, therefore, resulting in sustainable coal mining. The management has also created environmental costs, as an externality of coal mining activities. Based on the technical assessment conducted, the results showed that environmental management at Tarahan Port Unit of PT BUKIT ASAM Persero Tbk, has been implemented in accordance with the Environmental Management/Monitoring Plan (RKL/RPL) documents, as well as the prevailing Indonesian laws and regulations. The physical and chemical parameters were observed to have met the standards of environmental quality, for a sustainable community. However, the economical assessment showed a mismatch between planned and realized environmental management costs. The funds used in the second quarter increased by IDR. 121,183,548 or 102.02%, compared to the realization program in that of the first. This increase was due to the construction of a dust suppression system and an operational chimney for the 2X8 MW Steam Power Plant, via the use of Electrostatic Precipitators. This research recommended a detailed inventory of environmental cost plans and escalation, in order to anticipate risk factors. And also help in carrying out machine maintenances, which are known to produce emissions on a regular basis. Therefore the emission produced were observed to be decreased, with the funds for managing and monitoring the environment also reduced.
Prognostic Utility of Optical Coherence Tomography for Visual Outcome After Extended Endoscopic Endonasal Surgery for Adult Craniopharyngiomas
Authors: Qiao Ning , Li Chuzhong , Xu Jing , Ma Guofo , Kang Jie , Jin Lu , Cao Lei , Liu Chunhui , Zhang Yazhuo , Gui Song-Bai 
Published: June 2021

Abstract
Optical coherence tomography (OCT) serving as a novel high resolution imaging technique can assess the retinal morphology. At present, a few studies are reported with limited evidence on the predictive value of OCT for visual outcome after optic nerve decompression. This study aims to utilize the largest series of adult craniopharyngiomas to evaluate the association between OCT parameters and visual outcome following the extended endoscopic endonasal surgery (EEES). From October 2018 to October 2020, one hundred and seventy eyes in 88 adult patients with craniopharyngiomas were retrospectively reviewed. Gross total resection was performed in 82 (93.2%) patients. The median follow-up time was 10.9 months. Our study showed that increased temporal circumpapillary retinal nerve fiber layer (cpRNFL) thickness was associated with higher odds of visual acuity (VA) improvement and maintenance (OR=1.070; P=0.035), and greater inferior cpRNFL thickness was significantly associated with visual field (VF) improvement and maintenance (OR=1.034; P=0.046). Tight adhesion was demonstrated as an independent adverse factor for either postoperative VA or VF (P=0.048, P=0.030, respectively). Receiver operating characteristic (ROC) analysis further verified the robustness of the prediction model either in VA (AUC=0.842; P<0.001) or VF (AUC=0.849; P<0.001). Preoperative OCT can effectively predict visual outcome after EEES for adult craniopharyngiomas. It can also serve as a reliable alternative to evaluate preoperative visual filed defects, especially for patients with lower compliance. Tight adhesion was confirmed as an independent risk factor for postoperative visual outcome. The OCT-based multivariable prediction models developed in present study may contribute to patient counseling on visual prognosis.
Spectral Behavior and Photophysical Parameters of Dihydrophenanthro[9,10-e][1,2,4]Triazine Derivative Dyes in Sol–gel and Methyl Methacrylate Polymer Matrices
Authors: Sakr Mahmoud , Kana Maram T. H. Abou , Elwahy Ahmed H.M. , El-Daly Samy A. El-Daly A. , Ebeid El-Zeiny M. 
Published: June 2021

Abstract
This paper deals the optical and photophysical properties of dihydrophenanthro [9,10-e] [1,2,4] triazine fluorescent derivative dyes doped in Silicate based sol–gel, homo-poly methyl methacrylate (PMMA). Solid hosts effect on the optical and photophysical parameters such as molar absorptivity, cross sections of singlet–singlet electronic absorption and emission spectra, excited state lifetime, quantum yield of fluorescence. Also the dipole moment of electronic transition, the length of attenuation and Oscillator strength of electronic transition from So →S1 have been detected. The dyes with different pumping power were pumped by 3rd harmonic Nd:YAG pulsed laser 8ns pulse duration, with a repetition rate at (10Hz). Good Photo stability of compound 1 and 2 were obtained that was decreased to 49%, 54% and 46%, 40% of the initial ASE of dyes in sol gel and PMMA respectively, after 55000 pumping pulses at (10 mJ/pulse). The dyes in sol-gel show improved Photo stability compared with those in organic polymeric matrices.
Latitudinal- and Height- Dependent Long-Term Climatology of Propagating Quasi-16-day in the Troposphere and Stratosphere
Authors: Tang Wentao , ZHANG Shao Dong , HUANG Chun Ming , HUANG Kai Ming , Gong Yun , Gan Quan 
Published: June 2021

Abstract
The global amplitude of the westward propagating quasi-16-day wave (16DW) with wavenumber 1 (Q16W1), the strongest component of 16DW, is derived from European Centre for Medium-Range Weather Forecasts ERA-Interim reanalysis temperature data set from February 1979 to January 2018. The strong climatological mean amplitudes of the Q16W1 appear in winter in the upper stratosphere at high latitudes in both hemispheres, and the wave amplitude is stronger in the Northern Hemisphere (NH) than in the Southern Hemisphere (SH). Multivariate linear regression is applied to calculate responses of the Q16W1 amplitude to QBO (quasi-biennial oscillation), ENSO (El Niño-Southern Oscillation), solar activity and the linear trend of the Q16W1 amplitude. The QBO signatures of the Q16W1 amplitude are mainly located in the stratosphere. In addition to the significant QBO response in the low latitude and low stratosphere, the largest QBO response occurs in the region with the strongest Q16W1 climatology amplitude. There no significant responses to ENSO and solar activity are observed. The linear trend of the monthly mean Q16W1 amplitude is generally positive, especially in the mid-high latitudes of the stratosphere. The trend is asymmetric about the equator and significantly stronger in the NH than in the SH. The trend shows obvious seasonal changes, that is, stronger in winter, weaker in spring and autumn. Further investigation suggests that the background and local instability trends contribute most of the increasing trend of the Q16W1 amplitude. In winter in both hemispheres, the weakening trend of eastward zonal wind provide more favourable background wind for Q16W1 upward propagation, in autumn and winter in the NH and in spring, autumn and winter in the SH, the increasing trend of local instability may enhance the wave excitation.