bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variations in cardiac implantable electronic device surveillance and ancillary testing in the paediatric and congenital heart disease population: an international multi-centre survey from the Paediatric and Congenital Electrophysiology Society
Authors: Olen Melissa M. , Dechert Brynn E. , Foster Anne , Kanter Ronald J. , Silka Michael J. , Shah Maully J. 
Published: October 2021

AbstractBackground:Expert guidance from scientific societies and regulatory agencies recommend a framework of principles for frequency of in-person evaluations and remote monitoring for patients with cardiac implantable electronic devices. However, there are limited data regarding adherence to recommendations among paediatric electrophysiologists, and there are no data regarding cardiac implantable electronic device-related ancillary testing.Methods:To assess current clinical practices for cardiac implantable electronic device in-person evaluation, remote monitoring, and cardiac implantable electronic device-related ancillary testing, the Paediatric and Congenital Electrophysiology Society members were surveyed. The main outcome measures were variations in frequency of in person evaluation, frequency of remote monitoring, and cardiac implantable electronic device-related ancillary testing.Results:All respondents performed in-person evaluation at least once a year, but <50% of respondents performed an in-person evaluation within 2 weeks of cardiac implantable electronic device implantation. Remote monitoring was performed every 3 months for pacemakers and implantable cardioverter defibrillators by 71 and 75% respondents, respectively. Follow-up echocardiography was performed every 2–3 years by 53% respondents for patients with >50% ventricular pacing. Majority of respondents (75%) did not perform either an exercise stress test or ambulatory Holter monitoring or chest X-ray (65%) after cardiac implantable electronic device implantation.Conclusion:This survey identified significant practice variations in cardiac implantable electronic device in- person evaluation, remote monitoring, and ancillary testing practices among paediatric electrophysiologists. Cardiac implantable electronic device management may be optimised by development of a paediatric-specific guidelines for follow-up and ancillary testing.
Benchmarking for accountability on obesity prevention: evaluation of the Healthy Food Environment Policy Index (Food-EPI) in Australia (2016–2020)
Authors: Kwon Janelle , Reeve Erica , Mann Davina , Swinburn Boyd , Sacks Gary 
Published: October 2021

AbstractObjective:Despite broad agreement on the need for comprehensive policy action to improve the healthiness of food environments, implementation of recommended policies has been slow and fragmented. Benchmarking is increasingly being used to strengthen accountability for action. However, there have been few evaluations of benchmarking and accountability initiatives to understand their contribution to policy change. This study aimed to evaluate the impact of the Healthy Food Environment Policy Index (Food-EPI) Australia initiative (2016–2020) that assessed Australian governments on their progress in implementing recommended policies for improving food environments.Design:A convergent mixed methods approach was employed incorporating data from online surveys (conducted in 2017 and 2020) and in-depth semi-structured interviews (conducted in 2020). Data were analysed against a pre-defined logic model.Setting:Australia.Participants:Interviews: twenty stakeholders (sixteen government, four non-government). Online surveys: fifty-three non-government stakeholders (52 % response rate) in 2017; thirty-four non-government stakeholders (36 % response rate) in 2020.Results:The Food-EPI process involved extensive engagement with government officials and the broader public health community across Australia. Food-EPI Australia was found to support policy processes, including as a tool to increase knowledge of good practice, as a process for collaboration and as an authoritative reference to support policy decisions and advocacy strategies.Conclusions:Key stakeholders involved in the Food-EPI Australia process viewed it as a valuable initiative that should be repeated to maximise its value as an accountability mechanism. The highly collaborative nature of the initiative was seen as a key strength that could inform design of other benchmarking processes.
Arctic Amplification of Precipitation Changes—The Energy Hypothesis
Authors: Pithan Felix , Jung Thomas 
Published: October 2021

AbstractTemperature and precipitation change more strongly in the Arctic than at lower latitudes, with central Arctic boreal winter precipitation projected to double in the 21st century in a high‐emission scenario. This enhanced hydrological sensitivity has been explained in terms of the Arctic moisture budget and attributed to either moisture advection or surface evaporation. Here, we show that boreal winter moisture availability is less sensitive to surface temperature change in the Arctic than at lower latitudes, questioning a central role of the moisture budget. Hydrological sensitivity, that is, precipitation change per unit temperature change, is similar in models with or without sea‐ice changes, suggesting a secondary role of surface flux changes. Instead, we propose that the Arctic's larger hydrological sensitivity is energetically driven. Increases in latent heat release from precipitation locally balance increased atmospheric radiative cooling in Arctic winter, consistent with process‐level understanding of radiatively driven cloud and precipitation formation.
Long‐Lasting Marine Heatwaves Instigated by Ocean Planetary Waves in the Tropical Indian Ocean During 2015–2016 and 2019–2020
Authors: Zhang Ying , Du Yan , Feng Ming , Hu Shijian 
Published: October 2021

AbstractMarine heatwaves (MHWs) in the tropical Indian Ocean (TIO) showed remarkable increases in duration and frequency during the satellite observing era, responding to rising sea surface temperature. Long‐lasting MHWs were found in three upwelling regions of the TIO in 2015–2016 and 2019–2020, closely related to persistent downwelling oceanic planetary waves. In 2015, a prolonged MHW (149 days) in the western TIO was initiated by the downwelling Rossby waves associated with the co‐occurring super El Niño and positive Indian Ocean dipole (IOD) events. In the following year, the negative IOD sustained the longest MHW (372 days) in the southeastern TIO, prompted by the eastward‐propagating equatorial Kelvin waves. In 2019–2020, the two longest MHWs recorded in the southwestern TIO (275 days in 2019 and 149 days in 2020) were maintained by the downwelling Rossby waves associated with the 2019 extreme IOD. This study revealed the importance of ocean dynamics in long‐lasting MHWs in the TIO.
Risk evaluation at municipality level of a COVID-19 outbreak incorporating relevant geographic data: the study case of Galicia
Authors: Carballosa Alejandro , Balsa-Barreiro José , Garea Adrián , García-Selfa David , Miramontes Ángel , Muñuzuri Alberto P. 
Published: October 2021

AbstractThe COVID-19 pandemic was an inevitable outcome of a globalized world in which a highly infective disease is able to reach every country in a matter of weeks. While lockdowns and strong mobility restrictions have proven to be efficient to contain the exponential transmission of the virus, its pervasiveness has made it impossible for economies to maintain this kind of measures in time. Understanding precisely how the spread of the virus occurs from a territorial perspective is crucial not only to prevent further infections but also to help with policy design regarding human mobility. From the large spatial differences in the behavior of the virus spread we can unveil which areas have been more vulnerable to it and why, and with this information try to assess the risk that each community has to suffer a future outbreak of infection. In this work we have analyzed the geographical distribution of the cumulative incidence during the first wave of the pandemic in the region of Galicia (north western part of Spain), and developed a mathematical approach that assigns a risk factor for each of the different municipalities that compose the region. This risk factor is independent of the actual evolution of the pandemic and incorporates geographic and demographic information. The comparison with empirical information from the first pandemic wave demonstrates the validity of the method. Our results can potentially be used to design appropriate preventive policies that help to contain the virus.
Measuring the effect of distance on the network topology of the Global Container Shipping Network
Authors: Tsiotas Dimitrios , Ducruet César 
Published: October 2021

AbstractThis paper examines how spatial distance affects network topology on empirical data concerning the Global Container Shipping Network (GCSN). The GCSN decomposes into 32 multiplex layers, defined at several spatial levels, by successively removing connections of smaller distances. This multilayer decomposition approach allows studying the topological properties of each layer as a function of distance. The analysis provides insights into the hierarchical structure and (importing and exporting) trade functionality of the GCSN, hub connectivity, several topological aspects, and the distinct role of China in the network’s structure. It also shows that bidirectional links decrease with distance, highlighting the importance of asymmetric functionality in carriers’ operations. It further configures six novel clusters of ports concerning their spatial coverage. Finally, it reveals three levels of geographical scale in the structure of GCSN (where the network topology significantly changes): the neighborhood (local connectivity); the scale of international connectivity (mesoscale or middle connectivity); and the intercontinental market (large scale connectivity). The overall approach provides a methodological framework for analyzing network topology as a function of distance, highlights the spatial dimension in complex and multilayer networks, and provides insights into the spatial structure of the GCSN, which is the most important market of the global maritime economy.
Development and evaluation of pH-sensitive biodegradable ternary blended hydrogel films (chitosan/guar gum/PVP) for drug delivery application
Authors: Ghauri Zunaira Huma , Islam Atif , Qadir Muhammad Abdul , Gull Nafisa , Haider Bilal , Khan Rafi Ullah , Riaz Tabinda 
Published: October 2021

AbstractpH responsive hydrogels have gained much attraction in biomedical fields. We have formulated ternary hydrogel films as a new carrier of drug. Polyelectrolyte complex of chitosan/guar gum/polyvinyl pyrrolidone cross-linked via sodium tripolyphosphate was developed by solution casting method. Fourier transform infrared spectroscopy, scanning electron microscopy and thermogravimetric analysis were conducted to examine the interactions between the polymeric chains, surface morphology and thermal stability, respectively. The swelling tests resulted that the swelling was reduced with the increase in the concentration of crosslinker due to the more entangled arrangement and less availability of pores in hydrogels. Ciprofloxacin hydrochloride was used as a model drug and its release in simulated gastric fluid, simulated intestinal fluid and phosphate buffer saline solution was studied. pH responsive behaviour of the hydrogels have subjected these hydrogels for drug release applications.
Feature fusion network based on strip pooling
Authors: Wang Gaihua , Zhai Qianyu 
Published: October 2021

AbstractContextual information is a key factor affecting semantic segmentation. Recently, many methods have tried to use the self-attention mechanism to capture more contextual information. However, these methods with self-attention mechanism need a huge computation. In order to solve this problem, a novel self-attention network, called FFANet, is designed to efficiently capture contextual information, which reduces the amount of calculation through strip pooling and linear layers. It proposes the feature fusion (FF) module to calculate the affinity matrix. The affinity matrix can capture the relationship between pixels. Then we multiply the affinity matrix with the feature map, which can selectively increase the weight of the region of interest. Extensive experiments on the public datasets (PASCAL VOC2012, CityScapes) and remote sensing dataset (DLRSD) have been conducted and achieved Mean Iou score 74.5%, 70.3%, and 63.9% respectively. Compared with the current typical algorithms, the proposed method has achieved excellent performance.
Lactate dehydrogenase activity staining demonstrates time-dependent immune cell infiltration in human ex-vivo burn-injured skin
Authors: Cuddihy Joshua , Wu Gongjie , Ho Laptin , Kudo Hiromi , Dannhorn Andreas , Mandalia Sundhiya , Collins Declan , Weir Justin , Spencer Ashley , Vizcaychipi Marcela , Takats Zoltan , Nagy Istvan 
Published: October 2021

AbstractBurn injuries constitute one of the most serious accidental injuries. Increased metabolic rate is a hallmark feature of burn injury. Visualising lactate dehydrogenase (LDH) activity has been previously used to identify metabolic activity differences, hence cell viability and burn depth in burn skin. LDH activity was visualised in injured and uninjured skin from 38 sub-acute burn patients. LDH activity aided the identification of spatially correlating immunocompetent cells in a sub-group of six patients. Desorption Electrospray Ionisation Mass Spectrometry Imaging (DESI MSI) was used to describe relative lactate and pyruvate abundance in burned and uninjured tissue. LDH activity was significantly increased in the middle and deep regions of burnt skin compared with superficial areas in burnt skin and uninjured tissue and positively correlated with post-burn time. Regions of increased LDH activity showed high pyruvate and low lactate abundance when examined with DESI-MSI. Areas of increased LDH activity exhibited cellular infiltration, including CD3 + and CD4 + T-lymphocytes and CD68 + macrophages. Our data demonstrate a steady increase in functional LDH activity in sub-acute burn wounds linked to cellular infiltration. The cell types associated are related to tissue restructuring and inflammation. This region in burn wounds is likely the focus of dysregulated inflammation and hypermetabolism.
A fan-attached jacket worn in an environment exceeding body temperature suppresses an increase in core temperature
Authors: Hashimoto Kahori , Horie Seichi , Nagano Chikage , Hibino Hiroyuki , Mori Kimiyo , Fukuzawa Kimie , Nakayama Masashi , Tanaka Hiroyuki , Inoue Jinro 
Published: October 2021

AbstractWe examined whether blowing hot air above body temperature under work clothing may suppress core temperature. Nine Japanese men engaged in two 30-min bicycle ergometer sessions at a workload of 40% VO2max at 40 °C and 50% relative humidity. The experiment was conducted without wearing any cooling apparatus (CON), wearing a cooling vest that circulated 10.0 °C water (VEST), and wearing a fan-attached jacket that transferred ambient air underneath the jacket at a rate of 30 L/s (FAN). The VEST and FAN conditions suppressed the increases of rectal temperature (CON, VEST, FAN; 38.01 ± 0.19 °C, 37.72 ± 0.12 °C (p = 0.0076), 37.54 ± 0.19 °C (p = 0.0023), respectively), esophageal temperature (38.22 ± 0.30 °C, 37.55 ± 0.18 °C (p = 0.0039), 37.54 ± 0.21 °C (p = 0.0039), respectively), and heart rate (157.3 ± 9.8 bpm, 136.9 ± 8.9 bpm, (p = 0.0042), 137.5 ± 6.5 bpm (p = 0.0023), respectively). Two conditions also reduced the estimated amount of sweating and improved various subjective evaluations. Even in the 40 °C and 50% relative humidity environment, we may recommend wearing a fan-attached jacket because the heat dissipation through evaporation exceeded the heat convection from the hot ambient air.
Protected areas are not effective for the conservation of freshwater insects in Brazil
Authors: Dias-Silva Karina , Vieira Thiago Bernardi , Moreira Felipe Ferraz Figueiredo , Juen Leandro , Hamada Neusa 
Published: October 2021

AbstractBiodiversity conservation has faced many challenges, especially the conversion of natural areas that compete with use for agriculture, energy production and mineral extraction. This problem is further aggravated by lack of knowledge of the biodiversity that exists and the geographical distribution of different groups. The objectives of our study were to examine the distributional pattern of Gerromorpha diversity in Brazil, create a map of conservation priority areas, estimate the degree of protection that the current network of protected areas guarantees to this insect group, and identify the size thresholds in geographical distributions that would allow species to be protected. We used species occurrences from the Water Bugs Distributional Database, and we used 19 bioclimatic variables to build models of the potential distributions of species using the MaxEnt program. Using the potential model results, we calculated diversity metrics and overlapped them with the current state and federal “conservation units” (protected areas for biodiversity) in Brazil. Total beta diversity and turnover portions were separated into two faunistic groups, one in northern and the other in southern Brazil. The Amazon has higher beta diversity than what was predicted by the null models. We detected a positive relationship between species distribution area and occurrence in conservation units. Conservation units with less than 250 km2do not protect Gerromorpha species. Our results reinforce the necessity of formulating new conservation strategies for this group, contemplating species with both restricted and ample distributions, because rare and specialist species are the most harmed by habitat reduction, given that they are more sensitive to environmental disturbance.
Surface energy balance of the Sygyktinsky Glacier, south Eastern Siberia, during the ablation period and its sensitivity to meteorological fluctuations
Authors: Osipov Eduard Y. , Osipova Olga P. 
Published: October 2021

AbstractThe physically based melt of the low elevation Eastern Siberian glaciers is poorly understood due to the lack of direct micrometeorological studies. We used an automatic meteorological station to record the meteorological and energy characteristics of the Sygyktinsky Glacier, south Eastern Siberia (56.8° N, 117.4° E, 2,560 m a.s.l.), during two ablation seasons and computed the surface energy balance (SEB) for 30-min intervals. The glacier ablation was both modeled and measured by stakes and a thermistor cable. The net radiation (Rnet) was the main contributor (71–75 W m−2, 89–95%) to the SEB (79 W m−2, 100%), followed by sensible (2–4 W m−2, 3–5%) and latent (2–3 W m−2, 2–4%) heat fluxes. The net shortwave radiation was the main positive component of Rnet, while the net longwave radiation was weak and either negative (− 15 W m−2in 2019) or positive (4 W m−2in 2020). The small proportion of turbulent fluxes in the SEB is explained by the low wind speed (1.2 m s−1). The glacier ablation was found to be more sensitive to changes in shortwave radiation and wind speed, suggesting the need to consider the atmospheric conditions of the ablation period (summer snowfalls, cloudiness, wind speed) when analyzing long-term trends in glacial changes.
Epithelial–mesenchymal transition and its transcription factors
Authors: Debnath Pallabi , Huirem Rohit Singh , Dutta Paloma , Palchaudhuri Santanu 
Published: October 2021

Abstract
Epithelial–mesenchymal transition or EMT is an extremely dynamic process involved in conversion of epithelial cells into mesenchymal cells, stimulated by an ensemble of signaling pathways, leading to change in cellular morphology, suppression of epithelial characters and acquisition of properties such as enhanced cell motility and invasiveness, reduced cell death by apoptosis, resistance to chemotherapeutic drugs etc. Significantly, EMT has been found to play a crucial role during embryonic development, tissue fibrosis and would healing, as well as during cancer metastasis. Over the years, work from various laboratories have identified a rather large number of transcription factors (TFs) including the master regulators of EMT, with the ability to regulate the EMT process directly. In this review, we put together these EMT TFs and discussed their role in the process. We have also tried to focus on their mechanism of action, their interdependency, and the large regulatory network they form. Subsequently, it has become clear that the composition and structure of the transcriptional regulatory network behind EMT probably varies based upon various physiological and pathological contexts, or even in a cell/tissue type-dependent manner.
SOLIS
Authors: Evans L. , Fontani F. , Vastel C. , Ceccarelli C. , Caselli P. , López-Sepulcre A. , Neri R. , Alves F. , Chahine L. , Favre C. , Lattanzi V. 
Published: October 2021

Context. Isotopic fractionation is an important tool for investigating the chemical history of our Solar System. In particular, the isotopic fraction of nitrogen (14N/15N) is lower in comets and other pristine Solar System bodies with respect to the value measured for the protosolar nebula, suggesting a local chemical enrichment of 15N during the formation of the Solar System. Therefore, interferometric studies of nitrogen fractionation in Solar System precursors are needed for us to obtain clues about our astrochemical origins.
Aims. In this work we have investigated the variation in the 14N/15N ratio in one of the closest analogues of the environment in which the Solar System was born: the protocluster OMC-2 FIR4. We present the first comparison at high angular resolution between HCN and N2H+ using interferometric data.
Methods. We analysed observations of the HCN isotopologues H13CN and HC15N in the OMC-2 FIR4 protocluster. Specifically, we observed the transitions H13CN (1−0) and HC15N (1−0) with the NOrthern Extended Millimeter Array (NOEMA) within the context of the IRAM Seeds Of Life In Space (SOLIS) Large Program. We combined our results with analysis of archival data obtained with the Atacama Large Millimeter Array of N2H+ and its 15N isotopologues.
Results. Our results show a small regional variation in the 14N/15N ratio for HCN, from ~250 to 500. The ratios in the central regions of FIR4, where the candidate protostars are located, are largely consistent with one another and within that range (~300). They also show little variation from the part of the protocluster known to harbour a high cosmic-ray ionisation rate to the portion with a lower rate. We also found a small variation in the 14N/15N ratio of N2H+ across different regions, from ~200 to ~400.
Conclusions. These results suggest that local changes in the physical parameters occurring on the small linear scales probed by our observations in the protocluster do not seem to affect the 14N/15N ratio in either HCN or N2H+ and hence that this is independent of the molecule used. Moreover, the high level of irradiation due to cosmic rays does not affect the N fractionation either.
SOP CRS und HIPEC für peritoneale Metastasen mit gastrointestinalem Ursprung
Authors: Blaj Sebastian , Piso Pompiliu 
Published: October 2021

ZusammenfassungDie peritoneal metastasierten Malignome des Gastrointestinaltrakts stellen eine therapeutische Herausforderung dar. Die makroskopisch komplette zytoreduktive Chirurgie (CRS) gefolgt von hyperthermer intraperitonealer Chemotherapie (HIPEC) ermöglicht eine substanzielle Verbesserung des Outcomes bei hochselektionierten Patienten gegenüber alleiniger systemischer Chemotherapie 1. Diese SOP beschreibt die Auswahlkriterien und das Vorgehen.