bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative analysis of the outcome of malaria case surveillance strategies in Sri Lanka in the prevention of re‐establishment phase
Authors: Gunasekera W. M. Kumudunayana T. de A. W. , Premaratne Risintha , Fernando Deepika , Munaz Muzrif , Piyasena M. G. Y. , Perera Devika , Wickremasinghe Rajitha , Ranaweera K. D. N. Prasad , Mendis Kamini 
Published: February 2021

Abstract
Background
Sri Lanka sustained its malaria-free status by implementing, among other interventions, three core case detection strategies namely Passive Case Detection (PCD), Reactive Case Detection (RACD) and Proactive Case Detection (PACD). The outcomes of these strategies were analysed in terms of their effectiveness in detecting malaria infections for the period from 2017 to 2019.

Methods
Comparisons were made between the surveillance methods and between years, based on data obtained from the national malaria database and individual case reports of malaria patients. The number of blood smears examined microscopically was used as the measure of the volume of tests conducted. The yield from each case detection method was calculated as the proportion of blood smears which were positive for malaria. Within RACD and PACD, the yield of sub categories of travel cohorts and spatial cohorts was ascertained for 2019.

Results
A total of 158 malaria cases were reported in 2017–2019. During this period between 666,325 and 725,149 blood smears were examined annually. PCD detected 95.6 %, with a yield of 16.1 cases per 100,000 blood smears examined. RACD and PACD produced a yield of 11.2 and 0.3, respectively. The yield of screening the sub category of travel cohorts was very high for RACD and PACD being 806.5 and 44.9 malaria cases per 100,000 smears, respectively. Despite over half of the blood smears examined being obtained by screening spatial cohorts within RACD and PACD, the yield of both was zero over all three years.

Conclusions
The PCD arm of case surveillance is the most effective and, therefore, has to continue and be further strengthened as the mainstay of malaria surveillance. Focus on travel cohorts within RACD and PACD should be even greater. Screening of spatial cohorts, on a routine basis and solely because people are resident in previously malarious areas, may be wasteful, except in situations where the risk of local transmission is very high, or is imminent. These findings may apply more broadly to most countries in the post-elimination phase.
Effects of reverse deployment of cone-shaped vena cava filter on improvements in hemodynamic performance in vena cava
Authors: Chen Ying , Xu Zaipin , Deng Xiaoyan , Yang Shibo , Tan Wenchang , Fan Yubo , Han Yong , Xing Yubin 
Published: February 2021

Abstract
Background
Cone-shaped vena cava filters (VCFs) are widely used to treat venous thromboembolism. However, in the long term, the problem of occlusion persists even after the filter is deployed. A previous study hypothesized that the reverse deployment of a cone-shaped VCFs may prevent filter blockage.

Methods
To explore this hypothesis, a comparative study of the traditional and reverse deployments of VCFs was conducted using a computational fluid dynamics approach. The distribution of wall shear stress (WSS) and shear stress-related parameters were calculated to evaluate the differences in hemodynamic effects between both conditions. In the animal experiment, we reversely deployed a filter in the vena cava of a goat and analyzed the blood clot distribution in the filter.

Results
The numerical simulation showed that the reverse deployment of a VCF resulted in a slightly higher shear rate on the thrombus, and no reductions in the oscillating shear index (OSI) and relative residence time (RRT) on the vessel wall. Comparing the traditional method with the reversely deployed cases, the shear rate values is 16.49 and 16.48 1/s, respectively; the minimal OSI values are 0.01 and 0.04, respectively; in the vicinity of the VCF, the RRT values are both approximately 5 1/Pa; and the WSS is approximately 0.3 Pa for both cases. Therefore, the reverse deployment of cone-shaped filters is not advantageous when compared with the traditional method in terms of local hemodynamics. However, it is effective in capturing thrombi in the short term, as demonstrated via animal experiments. The reversely deployed cone-shaped filter captured the thrombi at its center in the experiments.

Conclusions
Thus, the reverse deployment of cone-shaped filters is not advantageous when compared with the traditional method in terms of local hemodynamics. Therefore, we would not suggest the reverse deployment of the cone-shaped filter in the vena cava to prevent a potentially fatal pulmonary embolism.
Guild-based analysis for understanding gut microbiome in human health and diseases
Authors: Wu Guojun , Zhao Naisi , Zhang Chenhong , Lam Yan Y. , Zhao Liping 
Published: February 2021

AbstractTo demonstrate the causative role of gut microbiome in human health and diseases, we first need to identify, via next-generation sequencing, potentially important functional members associated with specific health outcomes and disease phenotypes. However, due to the strain-level genetic complexity of the gut microbiota, microbiome datasets are highly dimensional and highly sparse in nature, making it challenging to identify putative causative agents of a particular disease phenotype. Members of an ecosystem seldomly live independently from each other. Instead, they develop local interactions and form inter-member organizations to influence the ecosystem’s higher-level patterns and functions. In the ecological study of macro-organisms, members are defined as belonging to the same “guild” if they exploit the same class of resources in a similar way or work together as a coherent functional group. Translating the concept of “guild” to the study of gut microbiota, we redefine guild as a group of bacteria that show consistent co-abundant behavior and likely to work together to contribute to the same ecological function. In this opinion article, we discuss how to use guilds as the aggregation unit to reduce dimensionality and sparsity in microbiome-wide association studies for identifying candidate gut bacteria that may causatively contribute to human health and diseases.
Neonatal mortality rates in Brazilian municipalities: from 1996 to 2017
Authors: Baroni Lais , Salles Rebecca , Salles Samella , Pedroso Marcel , Lima Jefferson , Morais Igor , Carraro Lucas , Saldanha Raphael de Freitas , Sousa Carlos , Cardoso Carlos , Paixño Balthazar , Cruz Sérgio , Ogasawara Eduardo , Boccolini Patrícia de Morais Mello , Boccolini Cristiano Siqueira 
Published: February 2021

Abstract
Objectives
Neonatal mortality is a global public health problem, and the efforts to reduce child mortality is one of the goals of the 2030 Agenda for Sustainable Development, launched in 2015 by the United Nations. The availability of historical neonatal mortality rates (NMR) data in Brazilian municipalities is crucial to evaluate trends at local, regional and national level, identifying gaps and vulnerable territories. Therefore, the objective of this article is to offer an integrated dataset containing monthly data in a historical series from 1996 to 2017 with information on all births, neonatal deaths, and NMR (total, early and late components) enriched with information related to the municipality.

Data description
It is a dataset of historical data with information on the number of births, the number of neonatal deaths, the neonatal mortality rate (including early and late), and geographic information for each month (between January 1996 and December 2017) and Brazilian municipality.
A nomenclature for fossil and living turtles using phylogenetically defined clade names
Authors: Joyce Walter G. , Anquetin Jérémy , Cadena Edwin-Alberto , Claude Julien , Danilov Igor G. , Evers Serjoscha W. , Ferreira Gabriel S. , Gentry Andrew D. , Georgalis Georgios L. , Lyson Tyler R. , Pérez-García Adán , Rabi Márton , Sterli Juliana , Vitek Natasha S. , Parham James F. 
Published: February 2021

AbstractOver the last 25 years, researchers, mostly paleontologists, have developed a system of rank-free, phylogenetically defined names for the primary clades of turtles. As these names are not considered established by the PhyloCode, the newly created nomenclatural system that governs the naming of clades, we take the opportunity to convert the vast majority of previously defined clade names for extinct and extant turtles into this new nomenclatural framework. Some previously defined names are converted with minor adjustments. We also define a number of new clade names to close apparent nomenclatural gaps. In total, we establish 113 clade names, of which 79 had already received phylogenetic definitions and 34 are new.ZooBank LSID: urn:lsid:zoobank.org:pub:43B418C2-BE9A-4BD5-91B7-8A9E0C8CB79D.
Potential synergy between PSMA uptake and tumour blood flow for prediction of human prostate cancer aggressiveness
Authors: Jochumsen Mads Ryø , Sörensen Jens , Tolbod Lars Poulsen , Pedersen Bodil Ginnerup , Frøkiær Jørgen , Borre Michael , Bouchelouche Kirsten 
Published: February 2021

AbstractBackgroundBoth prostate-specific membrane antigen (PSMA) uptake and tumour blood flow (TBF) correlate with International Society of Urological Pathology (ISUP) Grade Group (GG) and hence prostate cancer (PCa) aggressiveness. The aim of the present study was to evaluate the potential synergistic benefit of combining the two physiologic parameters for separating significant PCa from insignificant findings.MethodsFrom previous studies of [82Rb]Rb positron emission tomography (PET) TBF in PCa, the 43 patients that underwent clinical [68Ga]Ga-PSMA-11 PET were selected for this retrospective study. Tumours were delineated on [68Ga]Ga-PSMA-11 PET or magnetic resonance imaging. ISUP GG was recorded from 52 lesions.Results[68Ga]Ga-PSMA-11 maximum standardized uptake value (SUVmax) and [82Rb]Rb SUVmax correlated moderately with ISUP GG (rho = 0.59 and rho = 0.56, both p < 0.001) and with each other (r = 0.65, p < 0.001). A combined model of [68Ga]Ga-PSMA-11 and [82Rb]Rb SUVmax separated ISUP GG > 2 from ISUP GG 1–2 and benign with an area-under-the-curve of 0.85, 96% sensitivity, 74% specificity, and 95% negative predictive value. The combined model performed significantly better than either tracer alone did (p < 0.001), primarily by reducing false negatives from five or six to one (p ≤ 0.025).ConclusionPSMA uptake and TBF provide complementary information about tumour aggressiveness. We suggest that a combined analysis of PSMA uptake and TBF could significantly improve the negative predictive value and allow non-invasive separation of significant from insignificant PCa.
A sample decreasing threshold greedy-based algorithm for big data summarisation
Authors: Li Teng , Shin Hyo-Sang , Tsourdos Antonios 
Published: February 2021

AbstractAs the scale of datasets used for big data applications expands rapidly, there have been increased efforts to develop faster algorithms. This paper addresses big data summarisation problems using the submodular maximisation approach and proposes an efficient algorithm for maximising general non-negative submodular objective functions subject tok-extendible system constraints. Leveraging a random sampling process and a decreasing threshold strategy, this work proposes an algorithm, named Sample Decreasing Threshold Greedy (SDTG). The proposed algorithm obtains an expected approximation guarantee of$$\frac{1}{1+k}-\epsilon $$11+k-ϵfor maximising monotone submodular functions and of$$\frac{k}{(1+k)^2}-\epsilon $$k(1+k)2-ϵin non-monotone cases with expected computational complexity of$$O\left(\frac{n}{(1+k)\epsilon }\ln \frac{r}{\epsilon }\right)$$On(1+k)ϵlnrϵ. Here,ris the largest size of feasible solutions, and$$\epsilon \in \left(0, \frac{1}{1+k}\right)$$ϵ∈0,11+kis an adjustable designing parameter for the trade-off between the approximation ratio and the computational complexity. The performance of the proposed algorithm is validated and compared with that of benchmark algorithms through experiments with a movie recommendation system based on a real database.
Impact of hypothermia on the biomechanical effect of epithelium-off corneal cross-linking
Authors: Abdshahzadeh Hormoz , Abrishamchi Reyhaneh , Torres-Netto Emilio A. , Kling Sabine , Hafezi Nikki L. , Hillen Mark , Hafezi Farhad 
Published: February 2021

Abstract
Background
The corneal cross-linking (CXL) photochemical reaction is essentially dependent on oxygen and hypothermia, which usually leads to higher dissolved oxygen levels in tissues, with potentially greater oxygen availability for treatment. Here, we evaluate whether a reduction of corneal temperature during CXL may increase oxygen availability and therefore enhance the CXL biomechanical stiffening effect in ex vivo porcine corneas.

Methods
One hundred and twelve porcine corneas had their epithelium manually debrided before being soaked with 0.1% hypo-osmolaric riboflavin. These corneas were equally assigned to one of four groups. Groups 2 and 4 underwent accelerated epithelium-off CXL using 9 mW/cm2 irradiance for 10 min, performed either in a cold room temperature (group 2, 4 °C) or at standard room temperature (group 4, 24 °C). Groups 1 and 3 served as non-cross-linked, temperature-matched controls. Using a stress-strain extensometer, the elastic moduli of 5-mm wide corneal strips were analyzed as an indicator of corneal stiffness.

Results
Accelerated epithelium-off CXL led to significant increases in the elastic modulus between 1 and 5% of strain when compared to non-cross-linked controls (P < 0.05), both at 4 °C (1.40 ± 0.22 vs 1.23 ± 0.18 N/mm) and 24 °C (1.42 ± 0.15 vs 1.19 ± 0.11 N/mm). However, no significant difference was found between control groups (P = 0.846) or between groups in which CXL was performed at low or standard room temperature (P = 0.969).

Conclusions
Although initial oxygen availability should be increased under hypothermic conditions, it does not appear to play a significant role in the biomechanical strengthening effect of epithelium-off CXL accelerated protocols in ex vivo porcine corneas.
Decomposition and stabilization of organic matter in an old-growth tropical riparian forest: effects of soil properties and vegetation structure
Authors: de Godoy Fernandes Pedro Henrique , de Souza Andréa Lúcia Teixeira , Tanaka Marcel Okamoto , Sebastiani Renata 
Published: February 2021

Abstract
Background
Nutrient cycling in tropical forests has a large importance for primary productivity, and decomposition of litterfall is a major process influencing nutrient balance in forest soils. Although large-scale factors strongly influence decomposition patterns, small-scale factors can have major influences, especially in old-growth forests that have high structural complexity and strong plant-soil correlations. Here we evaluated the effects of forest structure and soil properties on decomposition rates and stabilization of soil organic matter using the Tea Bag Index (TBI) in an old-growth riparian forest in southeastern Brazil. These data sets were described separately using Principal Components Analysis (PCA). The main axes for each analysis, together with soil physical properties (clay content and soil moisture), were used to construct structural equations models that evaluated the different parameters of the TBI, decomposition rates and stabilization factor. The best model was selected using Akaike’s criterion.

Results
Forest structure and soil physical and chemical properties presented large variation among plots within the studied forest. Clay content was strongly correlated with soil moisture and the first PCA axis of soil chemical properties, and model selection indicated that clay content was a better predictor than this axis. Decomposition rates presented a large variation among tea bags (0.009 and 0.098 g·g− 1·d− 1) and were positively related with forest structure, as characterized by higher basal area, tree density and larger trees. The stabilization factor varied between 0.211–0.426 and was related to forest stratification and soil clay content.

Conclusions
The old-growth forest studied presented high heterogeneity in both forest structure and soil properties at small spatial scales, that influenced decomposition processes and probably contributed to small-scale variation in nutrient cycling. Decomposition rates were only influenced by forest structure, whereas the stabilization factor was influenced by both forest structure and soil properties. Heterogeneity in ecological processes can contribute to the resilience of old-growth forests, highlighting the importance of restoration strategies that consider the spatial variation of ecosystem processes.
Improving health benefits with considering traditional and modern health benefits of Peganum harmala
Authors: Shahrajabian Mohamad Hesam , Sun Wenli , Cheng Qi 
Published: February 2021

Abstract
Background
Medicinal plants are potential source of natural products that play an important role in preventing different human diseases. P. harmala is used traditionally as emmenagogue and an abortifacient agent in the Middle East, North of Africa and West of China. It belongs to the family of Zygophyllaceae and it is a wild growing flowering plant. Its seeds are main medicinal part of the plant.

Methods
The current searching was done by the keywords in main indexing systems including PubMed/MEDLINE, Scopus, and Institute for Scientific Information Web of Science as well as the search engine of Google Scholar. The keywords were wild rue, traditional medicine, Harman, health benefits, and pharmaceutical science.

Results
The most important uses of P. harmala in traditional pharmaceutical sciences are in cardiovascular, gasterointestinal, nervous, endocrine, neoplasm and tumors, pain relieving, organisms, diabetes, respiratory, disinfectant, anti-pyretic, skin and hair, rheumatism, arthritis and inflammation, and ulcers. Pharmacological effects of P. harmala are in cardiovascular system, nervous system, antimicrobial effects, antineoplasm, nervous system, endocrine, gastrointestinal effects, osteocytes, endocrine and respiratory system. Phenolic compounds are the main reason of antioxidant capacity.

Conclusions
Due to its pharmacological activities, P. harmala is a high potential medicinal herb and the suggestion is to increases by doing research in efficacy and safety.
Sorghum halepense (L.) Pers rhizomes inhibitory potential against diabetes and free radicals
Authors: Shah Muhammad Abdur Rehman , Khan Rahmat Ali , Ahmed Mushtaq 
Published: February 2021

AbstractBackgroundOwing to the side effects of synthetic medicine and less effectiveness against different syndromes, the researchers have focused on phytotherapy to overcome these problems. The purpose of this project was to study the in vitro phytochemical, cytotoxic, total phenolic, antioxidant and antidiabetic activities of the methanol extract of the rhizome ofSorghum halepense(L.) Pers and itsn-hexane, chloroform and aqueous fractions. Thereafter, to conduct in vivo evaluation of the effective extract for its antidiabetic and antioxidant characteristics.MethodsCytotoxic, total phenolic content and antidiabetic properties were ascertained by brine shrimps lethality, Folin- Ciocalteu reagent and alpha-amylase inhibition assays respectively while antioxidant activities were investigated through DPPH, ABTS and H2O2assays. The methanolic extract was assessed in vivo for its antidiabetic and antioxidant activities by using Wistar albino rats.ResultsThe phytochemical investigation of the methanolic extract and its unlike fractions revealed the availability of alkaloids, cardiac glycosides, flavonoids, terpenes, steroids, carbohydrate and proteins while lack of saponins and gums in methanolic extract. Steroids and carbohydrates were only present in aqueous and chloroform fraction respectively while both fractions contained proteins and alkaloids. Cardiac glycosides and flavonoids were absent in aqueous and chloroform fractions respectively. The highest brine shrimps lethality (70.5 ± 1.2), total phenolic content (28.30 ± 1.3 mg GAE/g), free radicals scavenging potential i.e. DPPH (40.02%), ABTS (40.48%) and H2O2(50.85%) and alpha amylase inhibition (61.87%) was shown by the methanolic extract. The in vivo results did not disclose any sign of acute toxicity. The diabetic control showed a noteworthy (P < 0.05) decline in weight, HDL and glutathione and a raised level of bilirubin, blood glucose, urea, creatinine, triglyceride, LDL, VLDL, ALT, ALP, AST, SOD, catalase. The mentioned alterations were restored considerably (P < 0.05) by treatment of diabetic rats with methanolic extract ofSorghum halepense(L.) Pers (150 and 300 mg/kg b.w.).ConclusionIt is concluded that the extract of rhizomes ofSorghum halepense(L.) Pers is an effective fount of antioxidant and anti-diabetic compounds. Further analysis is needed to sharpen its pharmacological activities.
Applications of 3D printing in breast cancer management
Authors: Galstyan Arpine , Bunker Michael J. , Lobo Fluvio , Sims Robert , Inziello James , Stubbs Jack , Mukhtar Rita , Kelil Tatiana 
Published: February 2021

AbstractThree-dimensional (3D) printing is a method by which two-dimensional (2D) virtual data is converted to 3D objects by depositing various raw materials into successive layers. Even though the technology was invented almost 40 years ago, a rapid expansion in medical applications of 3D printing has only been observed in the last few years. 3D printing has been applied in almost every subspecialty of medicine for pre-surgical planning, production of patient-specific surgical devices, simulation, and training. While there are multiple review articles describing utilization of 3D printing in various disciplines, there is paucity of literature addressing applications of 3D printing in breast cancer management. Herein, we review the current applications of 3D printing in breast cancer management and discuss the potential impact on future practices.
Organizational structure and CEO dominance
Authors: Schumacher Christian 
Published: February 2021

AbstractWe explore the effects of chief executive officers’ (CEOs’) personal dominance—an idiosyncratic character trait strongly associated with a desire for influence and control—on two fundamental organizational design decisions: the CEO’s span of control (1) and her delegation of responsibilities as reflected in the appointment of a chief operating officer (COO) (2). Linking three original measures of CEO dominance based on quarterly earnings calls with manually collected data on span of control and COO positions for a sample of CEOs presiding over large US corporations, we demonstrate that CEOs who are high in dominance have a significantly larger personal span of control and delegate fewer decision rights than less-dominant CEOs. We discuss implications of our findings and future questions from an organizational design perspective.