bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age- and sex-matched comparison of diet quality in patients with heart failure to similarly aged healthy older adults
Authors: Kang JungHee , Moser Debra K. , Biddle Martha J. , Oh GYeon , Lennie Terry A. 
Published: August 2021

AbstractThe aims of this study were to (1) compare diet quality between patients with heart failure (HF) and age- and sex-matched community-dwelling healthy older adults and (2) determine whether having HF was associated with a lower Healthy Eating Index-2015 (HEI-2015) score and risk of micronutrient deficiency. The HEI-2015 and macro- and micronutrient intakes of patients with HF were compared with healthy older adults (N102; 55–92 years old; 53 % female). A pairedt-test or Wilcoxon singed-rank test, McNemar's test, and conditional logistic regression were used to assess the association between diet quality and HF status. Median values for HEI-2015 and the number of micronutrient deficiency were used to dichotomise into groups in the conditional logistic regression. There was no significant between-group difference in the HEI-2015 total score (P0⋅059), whereas the whole grain component was lower in patients with HF than in healthy older adults (3⋅1 ± 3⋅5v.4⋅5 ± 3⋅1,P0⋅037; respectively). Total caloric intake was lower in patients with HF than in healthy older adults (1683 ± 595v.2104 ± 670 kcal;P< 0⋅001). Patients with HF had a higher average number of micronutrient deficiencies than healthy older adults (4[2, 6]v.1[0, 4], respectively,P< 0⋅001). Patients with HF had four times higher odds of being in a high micronutrient deficiency group than healthy older adults, controlling for socio-demographics and body mass index (adjusted odds ratio [95 % confidence interval]: 4⋅04[1⋅06, 15⋅41]). Our findings demonstrate that diet quality measured by nutritional intake identifies patients with HF with lower caloric intake and higher micronutrient deficiencies compared with age- and sex-matched healthy older adults.
On sectoriality of degenerate elliptic operators
Authors: Do Tan Duc 
Published: August 2021

AbstractLet $c_{kl} \in W^{1,\infty }(\Omega , \mathbb{C})$ for all $k,l \in \{1, \ldots , d\};$ and $\Omega \subset \mathbb{R}^{d}$ be open with uniformly $C^{2}$ boundary. We consider the divergence form operator $A_p = - \sum \nolimits _{k,l=1}^{d} \partial _l (c_{kl} \partial _k)$ in $L_p(\Omega )$ when the coefficient matrix satisfies $(C(x) \xi , \xi ) \in \Sigma _\theta$ for all $x \in \Omega$ and $\xi \in \mathbb{C}^{d}$, where $\Sigma _\theta$ be the sector with vertex 0 and semi-angle $\theta$ in the complex plane. We show that a sectorial estimate holds for $A_p$ for all $p$ in a suitable range. We then apply these estimates to prove that the closure of $-A_p$ generates a holomorphic semigroup under further assumptions on the coefficients. The contractivity and consistency properties of these holomorphic semigroups are also considered.
Comparative study of four known species of the genus Acrobeles von Linstow, 1877 (Nematoda, Cephalobidae) with ‘single’ and ‘double’ cuticle from coastal dunes in Spain
Authors: Ruiz-Cuenca A.N. , Abolafia J. 
Published: August 2021

Abstract
The nematode genus Acrobeles is composed of two morphological groups distinguished by the presence (‘double’ cuticle) or absence (‘single’ cuticle) of the refringent inner layer of the cuticle. In the present study, four species of this genus, two with ‘single’ cuticle (Acrobeles ciliatus and Acrobeles cylindricus) and two with ‘double’ (Acrobeles aenigmaticus and Acrobeles complexus) are studied from coastal dunes in Spain. This study provides detailed morphological and morphometrical analyses for the four species, while molecular analysis, based on 18S and 28S ribosomal DNA, is provided for A. complexus. The four species are studied with scanning electron microscopy, which is obtained for the first time for A. cylindricus. These analyses revealed morphological and molecular differentiations between both groups, appearing as two related monophyletic entities. The subgenera Acrobeles and Seleborca, formerly considered as separate genera, are proposed to accommodate both groups.
Impact on patients of the coronovirus disease 2019 pandemic and postponement of cochlear implant surgery: a qualitative study
Authors: Abrar R , Bruce I A , O'Driscoll M , Freeman S , de Estibariz U Martinez , Stapleton E 
Published: August 2021

AbstractObjectiveThis study aimed to explore the impact of the coronavirus disease 2019 pandemic and postponement of elective surgical procedures for profoundly deaf patients awaiting cochlear implantation.MethodOpen-ended questionnaires were sent to all adult patients awaiting cochlear implantation surgery. Qualitative analysis was performed using a grounded theory approach.ResultsParticipants described a primarily negative impact on wellbeing from the surgery delay, expressing feelings of isolation or loneliness. Low mood, depression or hopelessness were commonly expressed by elderly participants; frustration and anxiety were described by young adults. Participants described a negative impact on their general daily life, describing difficulties communicating with facemasks and struggles with reliance on telephone communication because of social distancing. Despite these significant psychosocial challenges, only a minority described adaptive coping strategies.DiscussionProfoundly deaf patients may be at greater psychosocial risk because of unique challenges from their hearing disability. Our findings can be used to develop evidence-driven strategies to improve communication, wellbeing and quality of life.
Ear fullness characteristics and prognosis in patients with all-frequency sudden sensorineural hearing loss
Authors: Zhou E , Xiao X-P , Liu B , Tan Z-Q , Miao G-Y , Liu X-B , Bu M-X , Cao X , Zhong J-Y 
Published: August 2021

AbstractObjectiveThis study investigated the characteristics and prognosis of the feeling of ear fullness in patients with unilateral all-frequency sudden sensorineural hearing loss.MethodsOur study included 56 patients with a diagnosis of unilateral all-frequency sudden sensorineural hearing loss accompanied by a feeling of ear fullness and 48 patients without a feeling of ear fullness. The condition of these patients was prospectively observed.ResultsPositive correlations were observed between grading of feeling of ear fullness and hearing loss in patients with a feeling of ear fullness (r = 0.599, p < 0.001). No significant differences were observed in the total effective rate of hearing recovery between patients with and without a feeling of ear fullness after one month of treatment (Z = −0.641, p = 0.521). Eighty-six per cent of patients (48 out of 56) showed complete recovery from the feeling of ear fullness. There was no correlation between feeling of ear fullness recovery and hearing recovery (r = 0.040, p = 0.769).ConclusionThe prognosis of feeling of ear fullness is good. There was no correlation between feeling of ear fullness recovery and hearing recovery for all-frequency sudden sensorineural hearing loss patients.
‘100 metres to the liquor store and 300 meters to the cemetery’ – individual, social, environmental and organisational facilitators and barriers to thriving in Swedish sheltered housing models
Authors: Corneliusson Laura , Sköldunger Anders , Sjögren Karin , Edvardsson David 
Published: August 2021

AbstractIn Sweden, sheltered housing is a housing model that provides accessible apartments with elevated social possibilities for older people. The environment within sheltered housing is expected to support resident health and reduce the need for care services. A previous study has shown that with increasing levels of depressive mood and decreasing levels of self-rated health and functional status, those residing in sheltered housing report higher levels of thriving compared to those ageing in place. Therefore, the aim of this study was to illuminate aspects of sheltered housing that are facilitators and/or barriers to thriving. Seven semi-structured group interviews in five different sheltered housing accommodations in Sweden were conducted between April 2019 and January 2020 (N = 38). The results, analysed using qualitative content analysis and presented in a model developed by Grol and Wensing, illuminate the four main categories of facilitators and barriers to thriving: individual factors, social context, environmental factors and organisational context. The results of this study show that the factors that influence experiences of thriving in sheltered housing are multifaceted and interconnected. Although the supportive environment provided in sheltered housing seems to contribute to thriving, the limited consideration towards the shifting health of residents is a barrier to thriving. The results of this study may assist in implementing tailored interventions to help support thriving on various levels.
The influence of floral traits on insect foraging behaviour on medicinal plants in an urban garden of eastern India
Authors: Chakraborty Pushan , Mukherjee Poulami Adhikary , Laha Supratim , Gupta Salil Kumar 
Published: August 2021

AbstractUnderstanding the pollination biology of medicinal plants and their important insect pollinators is necessary for their conservation. The present study explored the complex interactions between pollinator visitation and effect of floral traits on pollinator behaviour on seven medicinal plant species grown in an urban garden in West Bengal, an eastern Indian state. The observations revealed 30 morphospecies of insect flower visitors (Diptera, Lepidoptera and Hymenoptera) that touched floral reproductive parts on the selected plants during visitation. Additionally, it was observed that floral traits (e.g., corolla length and corolla opening diameter) were important predictors of the behaviour of insects when visiting the flowers. Plant–pollinator interactions were analysed using a bipartite network approach which explored the important links between insect and plants in the network revealing the key interactions, and species which are crucial to system maintenance. This piece of work contributes to our ability to understand and maintain a stable medicinal plant–pollinator network which will support efforts to conserve native flora and insects.
Contrasting effects of the Toll-like receptor 4 in determining ovarian follicle endowment and fertility in female adult mice
Authors: Gonçalves Júlio Panzera , Magalhães Breno Augusto , Campos-Junior Paulo Henrique Almeida 
Published: August 2021

AbstractToll-like receptor 4 (TLR4) is best known for its role in bacteria-produced lipopolysaccharide recognition. Regarding female reproduction, TLR4 is expressed by murine cumulus cells and participates in ovulation and in cumulus–oocyte complex (COC) expansion, maternal–fetal interaction and preterm labour. Despite these facts, the role of TLR4 in ovarian physiology is not fully understood. Therefore, the aim of the present study was to investigate the effects of TLR4 genetic ablation on mice folliculogenesis and female fertility, through analysis of reproductive crosses, ovarian responsiveness and follicular quantification in TLR4−/−(n =94) and C57BL/6 mice [wild type (WT),n =102]. TLR4-deficient pairs showed a reduced number of pups per litter (P =0.037) compared with WT. TLR4−/−mice presented more primordial, primary, secondary and antral follicles (P <0.001), however there was no difference in estrous cyclicity (P >0.05). A lower (P =0.006) number of COC was recovered from TLR4−/−mice oviducts after superovulation, and in heterozygous pairs, TLR4−/−females also showed a reduction in the pregnancy rate and in the number of fetuses per uterus (P =0.007) when compared with WT. Altogether, these data suggest that TLR4 plays a role in the regulation of murine folliculogenesis and in determining ovarian endowment. TLR4 deficiency may affect ovulation and pregnancy rates, potentially decreasing fertility, therefore the potential side effects of its blockade have to be carefully investigated.
Modulation of lipid metabolism through multiple pathways during oocyte maturation and embryo culture in bovine
Authors: Oliveira Clara Slade , Feuchard Viviane Luzia da Silva , Marques Sheila Costa de Souza , Saraiva Naiara Zoccal 
Published: August 2021

AbstractLipid accumulation occurs in cultured embryos and is associated with reduced cryotolerance. Here we report the use of a multiple pathway lipid modulator cocktail (l-carnitine, linoleic acid and forskolin) to improve cryosurvival. First, we stained oocytes and embryos with Oil Red to examine the time course of lipid accumulation duringin vitrofertilization (IVF) and embryo culture. Then we evaluated the effects of the lipid modulators cocktail on lipid content, developmental rates and survival after vitrification. In our conditions, lipid accumulation was detected (P <0.05) at the end ofin vitromaturation (IVM) and after 4 days of embryo culture (D4-D5). In experiment 1, we used lipid modulator cocktail during IVM. Reduced (P <0.05) lipid accumulation was detected in oocytes (Control: 49.9 ± 1.6, Lip. Mod. IVM: 45.0 ± 1.8) but no changes were present at blastocyst stage (Control: 62.4 ± 2.6, Lip. Mod. IVM: 66.8 ± 2.7). Treated oocytes presented decreased (P <0.05) blastocyst rates and lower (P <0.05) re-expansion after vitrification. In experiment 2, lipid modulators cocktail was used during embryo culture (from D4–D7 or D6–D7). Treatment had an effect on lipid metabolism, as lipid content was increased (P <0.05) in D7 blastocysts in treated groups (Control: 52.7 ± 3.1a, D4: 65.9 ± 2.6b, D6: 78.1 ± 2.7b). However, no effect was present for cleavage, blastocyst and cryosurvival rates. No difference was detected in mean cell number comparing the three groups (Control: 78.9 ± 9.6, D4: 82.6 ± 16.5, D6: 68.3 ± 7.8), but apoptosis rate was increased (P <0.05) in vitrified-warmed blastocysts from treated groups (Control: 14.77*, D4: 22.28, D6: 22.22). We concluded that the combined use of lipid modulators was efficient to promote changes in lipid content of oocytes and embryos in bovine, but those changes did not reflect positively on embryo development or cryosurvival.
Unmet mental health needs in patients with advanced B-cell lymphomas
Authors: Marte Chrystal , George Login S. , Rutherford Sarah C. , Ouyang Daniel Jie , Martin Peter , Leonard John P. , Trevino Kelly M. 
Published: August 2021

AbstractContextExisting research on psychological distress and mental health service utilization has focused on common types of solid tumor cancers, leaving significant gaps in our understanding of patients experiencing rare forms of hematologic cancers.ObjectiveTo examine distress, quality of life, and mental health service utilization among patients with aggressive, refractory B-cell lymphomas.MethodPatients (n = 26) with B-cell lymphomas that relapsed after first- or second-line treatment completed self-report measures of distress (Hospital Anxiety and Depression Scale) and quality of life (Short-Form Health Survey, SF-12). Patients also reported whether they had utilized mental health treatment since their cancer diagnosis.ResultsApproximately 42% (n = 11) of patients reported elevated levels of psychological distress. Of patients with elevated distress, only one quarter (27.2%; n = 3) received mental health treatment, while more than half did not receive mental health treatment (54.5%; n = 6), and 18.1% (n = 2) did not want treatment. Patients with elevated distress reported lower mental quality of life than patients without elevated distress [F (1, 25) = 15.32, p = 0.001].Significance of the resultsA significant proportion of patients with advanced, progressive, B-cell lymphomas may experience elevated levels of distress. Yet, few of these distressed patients receive mental health treatment. Findings highlight the need to better identify and address barriers to mental health service utilization among patients with B-cell lymphoma, including among distressed patients who decline treatment.
Breaking the silence about illness and death: Potential effects of a pilot study of the family talk intervention when a parent with dependent children receives specialized palliative home care
Authors: Weber Falk Megan , Eklund Rakel , Kreicbergs Ulrika , Alvariza Anette , Lövgren Malin 
Published: August 2021

AbstractObjectiveThe entire family is affected when a parent is severely ill. Parents often need and appreciate professional support when talking to children about illness and death. The family talk intervention (FTI) is family-centered and intends to promote communication about the illness and its consequences, support parenting to enhance family coping and help family members share experiences with each other to create a shared family history. This study aimed to explore potential effects of FTI in specialized palliative home care, as reported by parents.MethodThis pre-post test intervention pilot was conducted in specialized palliative home care. A convergent mixed-method design was used to analyze interview and questionnaire data. Twenty families with dependent children were recruited from two specialized palliative home care units in Stockholm, Sweden.ResultsParents reported that family communication improved after participation in FTI as family members learned communication strategies that facilitated open sharing of thoughts and feelings. Increased open communication helped family members gain a better understanding of each other's perspectives. Parents reported that relationships with their partner and children had improved as they now shared several strategies for maintaining family relationships. Parents were also less worried following participation in FTI. The ill parents stated that they gained a sense of security and were less worried about the future.Significance of resultsThis study adds to the evidence that FTI may be a useful intervention for families with dependent children and an ill parent in a palliative care setting. This trial is registered at ClinicalTrials.gov Identifier NCT03119545.
Revealing High‐Manganese Material on Mars at Microscale
Authors: Zeng Xiaojia , Wu Yanxue , Zhao Yuyan S. , Pang Runlian , Mo Bing , Wen Yuanyun , Li Xiongyao , Liu Jianzhong 
Published: August 2021

AbstractHigh‐manganese materials would provide valuable information about the history of a water‐rich and oxidizing environment on early Mars. However, the detailed texture and components of these high‐manganese materials are unknown. In martian breccia meteorite NWA 11220, one unique lithic clast enriched in high‐manganese material (~5 vol%) has been recognized. Here, we report the morphological, micro‐textural, mineralogical, and geochemical features of the martian high‐manganese material at the microscale for the first time. Our results show that (a) high‐manganese materials are characterized by micron‐sized grain (<50 μm), complex associated‐phase (i.e., apatite, enstatite, magnetite, ilmenite, and amorphous matrix), and chemical heterogeneity; (b) nano‐sized (<500 nm) amorphous manganese‐oxide veins or grains are the only manganese‐bearing phases in the high‐manganese materials. These new observations provide new evidence for revealing the geological processes related to the high‐manganese materials on Mars and provide important information for future in‐situ exploration and data interpretation of high‐manganese materials on Mars.
Grain Fabric Heterogeneity in Strained Shales: Insights From XCT Measurements
Authors: Saur H. , Moonen P. , Aubourg C. 
Published: August 2021

AbstractUnderstanding the fabric of rigid grains in strained shales is essential for predicting transport or mechanical properties. Fabric analysis of rigid grains is also key to infer deformation mechanisms in fine‐grained materials. In this study, we investigate the quartz shape fabric of two millimeter‐sized drill cores of tectonically deformed shales by means of X‐ray microtomography. The samples originate from the Jaca basin (Spain) and present a slaty cleavage perpendicular to the bedding. The representativeness of fabric data and heterogeneities are characterized at the microscale and compared with published magnetic fabric data. We extract both the individual grain data and the bulk data in sub‐volumes of increasing dimensions, and focus on identifiers, such as feature size, anisotropy, and shape. In the second step, the spatial heterogeneity of the matrix is assessed. We show that the bulk quartz fabric of a single millimeter‐sized sample is consistent with the magnetic fabric obtained based on a large number of centimeter‐sized samples. Yet, the individual grain analysis demonstrates that this bulk fabric hides a competition between two planar fabrics (bedding and cleavage), where both act differently depending on the grain size and morphology. Inter‐sample comparison reveals the existence of a petrofabric with a characteristic length that exceeds the sample size. These insights are directly applicable to the study of the bulk fabric at a larger scale. In this way, X‐ray microtomography complements petrophysical measurements in shales and helps to avoid misinterpretation of the rock fabric based on bulk measurements.
LINC00319 promotes cancer stem cell-like properties in laryngeal squamous cell carcinoma via E2F1-mediated upregulation of HMGB3
Authors: Yuan Linlin , Tian Xiufen , Zhang Yanfei , Huang Xinhui , Li Qing , Li Wencai , Li Shenglei 
Published: August 2021

AbstractLaryngeal squamous cell carcinoma (LSCC) is one of the most common subtypes of head and neck malignancies worldwide. Long intervening/intergenic noncoding RNAs (LINCRNAs) have been recently implicated in various biological processes that take place in the setting of laryngeal cancer, but the regulatory role of LINC00319 in LSCC remains largely unknown. The current study aimed to elucidate the regulatory effect of LINC00319 on the development and progression of LSCC via high-mobility group box 3 (HMGB3). Microarray-based analysis was initially conducted to identify differentially expressed long noncoding RNAs, after which the expression of LINC00319 and HMGB3 in LSCC tissues and cells was determined accordingly. CD133+CD144+ TU177 cells were subsequently isolated and transfected with LINC00319 overexpression vector (oe-LINC00319), short hairpin RNA (sh)-LINC00319, sh-HMGB3, sh-E2F transcription factor 1 (E2F1), and oe-E2F1, as well as their corresponding controls. The proliferative, invasion, self-renewal, and tumorigenic abilities of CD133+CD144+ TU177 cells were then evaluated. Our in vitro findings were further confirmed following subcutaneous injection of cells expressing the corresponding plasmids into nude mice. LINC00319 and HMGB3 expressions were elevated in LSCC cells and tissues. LINC00319 increased HMGB3 expression by recruiting E2F1. Furthermore, the stimulatory role of LINC00319 on the proliferation, invasion, self-renewal ability, and tumorigenicity of CD133+CD144+ TU177 cells was achieved by upregulating HMGB3 via recruitment of E2F1. The in vitro findings were also confirmed by in vivo experiments. Taken together, these data show that downregulating LINC00319 in CD133+CD144+ TU177 cells may serve as a potential anticancer regimen by inhibiting the proliferation and invasion of cancer stem cells in LSCC.