bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formation mechanisms of ringwoodite: clues from the Martian meteorite Northwest Africa 8705
Authors: Zhang Ting , Hu Sen , Wang Nian , Lin Yangting , Gu Lixin , Tang Xu , Zou Xinyu , Zhang Mingming 
Published: August 2021

AbstractRingwoodite and wadsleyite are the high-pressure polymorphs of olivine, which are common in shocked meteorites. They are the major constituent minerals in the terrestrial mantle. NWA 8705, an olivine-phyric shergottite, was heavily shocked, producing shock-induced melt veins and pockets associated with four occurrences of ringwoodite: (1) the lamellae intergrown with the host olivine adjacent to a shock-induced melt pocket; (2) polycrystalline assemblages preserving the shapes and compositions of the pre-existing olivine within a shock-induced melt vein (60 μm in width); (3) the rod-like grains coexisting with wadsleyite and clinopyroxene within a shock-induced melt vein; (4) the microlite clusters embedded in silicate glass within a very thin shock-induced melt vein (20 μm in width). The first two occurrences of ringwoodite likely formed via solid-state transformation from olivine, supported by their morphological features and homogeneous compositions (Mg# 64–62) similar to the host olivine (Mg# 66–64). The third occurrence of ringwoodite might fractionally crystallize from the shock-induced melt, based on its heterogeneous and more FeO-enriched compositions (Mg# 76–51) than those of the coexisting wadsleyite (Mg# 77–67) and the host olivine (Mg# 66–64) of this meteorite. The coexistence of ringwoodite, wadsleyite, and clinopyroxene suggests a post-shock pressure of 14–16 GPa and a temperature of 1650–1750 °C. The fourth occurrence of ringwoodite with compositional variation (Mg# 72–58) likely crystallized from melt at 16–18 GPa and 1750–1850 °C. The presence of the four occurrences of ringwoodite was probably due to their very fast cooling rates in and/or adjacent to the thin shock-induced melt veins and small pockets. In addition, the higher Fa-contents of the host olivine (Fa35–39) in NWA 8705 than those in ordinary chondrites (Fa16–32) makes the olivine–ringwoodite transformation prolong to a lower pressure.
Liquefaction in Palu: the cause of massive mudflows
Authors: Jalil Abdul , Fathani Teuku Faisal , Satyarno Iman , Wilopo Wahyu 
Published: August 2021

AbstractThe 7.5Mwtectonic earthquake that hit Palu City on 28 September 2018 was followed by tsunami and liquefaction, triggered massive mudflows in Balaroa, Petobo, and Jono Oge areas. This study focuses on the generating factors of liquefaction such as the condition of soil lithology, depth of water table, the distance to the focal mechanism, and the thickness of soft sediment. Microtremor data, including the Horizontal Vertical Spectral Ratio (HVSR), geological condition, and borehole data, were examined to conduct the liquefaction analysis. The analysis results based on the microtremor data showed that the distribution of ground shear strain values in Palu City ranged from 0.75 × 10–4to 2.56 × 10–4. The distribution of the locations of the liquefaction was correlated to the distribution of ground shear strain values. High ground shear strain values and a shallow groundwater level were discovered in Palu City valley, which indicates that liquefaction in Palu City will undoubtedly occur. The semi-empirical method confirmed that Balaroa, Petobo, and Jono Oge had undergone large-scale liquefaction at a maximum depth of 16 m below the ground level. The average peak of water runoff that generated the mudflow was estimated to be at 11.31 cm3/s. Since the soil has loose soil grain with high water content, the soil will turn into a massive amount of mud during the liquefaction.
Do Rates of Mental Health Symptoms in Currently Competing Elite Athletes in Paralympic Sports Differ from Non-Para-Athletes?
Authors: Olive Lisa S. , Rice Simon , Butterworth Matt , Clements Matti , Purcell Rosemary 
Published: August 2021

Abstract
Background
This study addresses the lack of comparative data on the mental health of athletes in Paralympic sports (‘para-athletes’) and non-para athletes by examining the prevalence and correlates of mental health symptoms in a national sample of elite athletes representative of the population from which it was drawn on age and para-status.

Methods
A cross-sectional, anonymous, online-survey was provided to all categorised (e.g. highest level) athletes, aged 17 years and older, registered with the Australian Institute of Sport (n = 1566). Measures included psychological distress, mental health caseness, risky alcohol consumption, body weight and shape dissatisfaction, self-esteem, life satisfaction, and problem gambling. Correlates of outcomes included individual (e.g. demographic and psychosocial) and sport-related variables.

Results
The participation rate was 51.7% (n = 810), with valid data available from 749 athletes. No significant differences were observed between athletes from para- and non-para-sports on most mental health symptoms, with the exception of alcohol consumption (p < .001) and self-esteem (p = .007), both lower in athletes from para-sports. A trend for an interaction was found for anxiety and insomnia (p = .018), whereby the difference between athletes from para- and non-para-sports was qualified by gender.

Conclusions
In a large sample of elite athletes, mental health and wellbeing symptoms are comparable between athletes from para- and non-para-sports, with the exception of para-athletes reporting lower alcohol consumption but also lower self-esteem. While overall mental health and wellbeing symptom profiles are largely similar, attention to areas of differences will help to better address the unmet and distinct mental health needs of athletes from para-sports.
The global molecular epidemiology of microsporidia infection in sheep and goats with focus on Enterocytozoon bieneusi: a systematic review and meta-analysis
Authors: Taghipour Ali , Bahadory Saeed , Javanmard Ehsan 
Published: August 2021

AbstractBackgroundMicrosporidia is a zoonotic pathogen with health consequences in immunocompromised patients. Small ruminants are a potential reservoir of microsporidia for humans in their vicinity. Hence, we aimed to evaluate the molecular prevalence of microsporidian infections with emphasis onEnterocytozoon bieneusigenotypes among sheep and goats at a global scale through systematic review and meta-analysis approach.MethodsThe standard protocol of preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines were followed. Eligible prevalence studies on small ruminant microsporidiosis, published from 1 January 2000 until 15 April 2021 were gathered using systematic literature search in PubMed, Scopus, Web of Science and Google Scholar databases. Inclusion and exclusion criteria were applied. The point estimates and 95% confidence intervals were calculated using a random-effects model. The variance between studies (heterogeneity) was quantified byI2index.ResultsIn total, 25 articles (including 34 datasets) were included for final meta-analysis. The pooled molecular prevalence of microsporidia in sheep and goats was estimated to be 17.4% (95% CI: 11.8–25%) and 16% (95% CI: 11.2–22.4%), respectively. Likewise, the overall prevalence ofE. bieneusiwas estimated to be 17.4% (95% CI: 11.8–25%) for sheep and 16.3% (95% CI: 11.3–22.8%) for goats. According to internal transcribed spacer (ITS) gene analysis,E. bieneusiwith genotypes BEB6 (15 studies) and COS-1 (nine studies) in sheep, and CHG3 (six studies) and BEB6 (five studies) in goats were the highest reported genotypes.ConclusionThe present results highlight the role of sheep and goats as reservoir hosts for human-infecting microsporidia. Therefore, this global estimate could be beneficial on preventive and control measures.
Ebola and COVID-19 in Democratic Republic of Congo: grappling with two plagues at once
Authors: Khan Fatima Muhammad Asad , Hasan Mohammad Mehedi , Kazmi Zohra , dos Santos Costa Ana Carla , Aborode Abdullahi Tunde , Ahmad Shoaib , Essar Mohammad Yasir 
Published: August 2021

AbstractIn February 2021, a new Ebola virus disease outbreak was confirmed amid the COVID-19 pandemic in the Democratic Republic of Congo. Although the country has successfully contained the outbreak amid its fight against the COVID-19 pandemic, the epidemiological situation is still concerning, primarily due to the risk of an increase in the number of COVID-19 cases. The coexistence of both outbreaks increased the burden on the country’s health system mainly because Ebola response programs were redirected to the COVID-19 national response. Strategies adopted and lessons learned from previous Ebola outbreaks were crucial to developing the COVID-19 national response. To tackle the challenges of combating both the viruses, it is essential to adopt multidisciplinary measures such as prevention, education, and vaccination campaigns, promoting hygiene and social distancing practices, and improving diagnostic and management protocols. This paper discusses the efforts, challenges, and possible solutions to grapple with Ebola amid the COVID-19 crisis in DRC successfully.
Linsitinib (OSI-906) modulates brain energy metabolism and seizure activity in the lithium-pilocarpine rat model
Authors: Jiang Guohui , Wang Shenglin , Chen Mingyue , Ding Xiaomi , He Weiwei , Wang Li , Wang Shunxian , Yu Juming , Wang Xiaoming 
Published: August 2021

Abstract
Background
Epileptic seizure is a process of energy accumulation, bursting, and depletion accompanied by the production, spread, and termination of epileptic discharges. The energy required for a seizure is mainly provided through mitochondrial production of ATP. Mitochondrial diseases often lead to epileptic seizures, and energy depletion caused by seizures can lead to mitochondrial dysfunction. The energy metabolism has become a key target for treatment of epileptic diseases.

Method
The effect of OSI-906, an insulin receptor (IR)/ insulin-like growth factor 1 receptor (IGF-1R) inhibitor, on behaviors and electroencephalographic activity in the lithium-pilocarpine rats were tested. 18F-FDG positron emission tomography (PET)/ computed tomography (CT) was performed to detect the relative whole-brain glucose uptake values. Electron microscopy was performed to observe the ultrastructure of neuronal and mitochondrial damage. The changes in blood glucose at different time points before and after the intervention were tested and the effects of OSI-906 on IR/IGF-1R and downstream Akt signaling in the context of seizures were evaluated.

Results
The OSI-906 treatment applied 3 days before the pilocarpine-induced seizures significantly reduced the seizure severity, prolonged the seizure latency and decreased the EEG energy density. MicroPET/CT revealed that 50 mg/kg of OSI-906 inhibited the 18F-FDG glucose uptake after epileptic seizures, suggesting that OSI-906, through inhibiting IR/IGF-1R and the downstream AKT signaling, may regulate the excessive energy consumption of the epileptic brain. The OSI-906 treatment also reduced the mitochondrial damage caused by epileptic seizures.

Conclusion
The IR/IGF-1R inhibitor OSI-906 can significantly reduce the sensitivity and severity of pilocarpine-induced seizures by inhibiting the IR/IGF-1R and the downstream Akt signaling pathway.
Vertical migration in theory and in practice
Authors: Rice Gary K. 
Published: August 2021

We use the term vertical migration to describe the mechanism of mass transport that moves trace petroleum hydrocarbons from subsurface accumulations to the surface. Vertical migration is the heart of geochemical exploration for petroleum. Although our use of geochemical exploration for petroleum has been accelerating, our understanding of the mechanism that makes the process successful lagged behind. Early vertical migration models were based on a molecular process called diffusion. Diffusion remained the accepted mechanism during the early years of geochemical exploration even though the diffusion mechanism could not explain many observations, including migration that appeared to be predominately vertical. Approximately 30 years ago, buoyancy-driven migration mechanisms were modeled. The models predicted how gases below the water table could migrate vertically as a gas phase with buoyancy providing a mechanism for predominately vertical gas migration. Buoyancy models explained how surface expressions observed from vertical migration measurements related to petroleum reservoirs including small lateral offsets. Buoyancy models also explained the gradients and data contrasts observed in many surface geochemical features including what they mean and predicted fast vertical migration rates that have been verified by field observations. In addition, buoyancy models predicted how petroleum reservoirs could be mapped using gas data and how surface expressions of faults and fractures could be mapped using liquid data. Those data can be obtained from direct measurement of trace hydrocarbons in near-surface fluid samples. Because reservoir rock samples are not required, vertical migration provides a way to obtain information about a reservoir prior to exploratory drilling. The characteristics of these migrating fluids and their surface patterns are the foundation of modern geochemical exploration for petroleum.
Airborne and ground geophysical evaluation of potential mineralized zone in parts of Ilesha schist belt, southwestern Nigeria
Authors: Ogungbemi Oluwaseun S. , Amigun John O. , Olayanju Gbenga M. , Olabode Badmus Ganiyu 
Published: August 2021

Integrated airborne and ground geophysical studies were conducted in parts of Ilesha schist belt, southwestern Nigeria. The goal was to provide a useful guide for mineral prospecting, with the hope of considerably narrowing down the future search for mineral deposits within the study area. Aeromagnetic and aeroradiometric data were analyzed for the reconnaissance study. In addition, the reduction-to-equator transform, analytic signal, tilt derivative, and Euler deconvolution filters were applied to the aeromagnetic data to enhance shallow and deep geologic features. The aeroradiometric data were used to determine spatial variations in the concentrations of uranium (U), thorium (Th), and potassium (K) in near-surface rocks and to map spatial lithologic changes. The 2D-magnetic sections, radiometric profiles, inverted resistivity, and induced polarization (IP) sections were generated from the integrated geophysical data. The electrical resistivity tomography (ERT) results reveal the subsurface heterogeneity (to a depth of approximately 197 m) and varied geoelectric layers (topsoil, lateritic-clay, weathered rock, and basement rock). The IP sections show varying degrees of chargeability and features that suggest the presence of disseminated mineralized bodies concealed in some areas. The overburden thickness varies between 4 and 85 m as determined from the 2D-magnetic and electric resistivity sections. Anomalous peaks on profiles of elemental ratios (eTh/K, eTh/eU, and K/eU) correlate with the results of IP and ERT. Data sets are well correlated and highlight areas with relevant structural and lithologic signatures favorable for mineral deposition. The methodology adopted in our research is well adapted, and the interpretation techniques provided insight into regional and local lithostructural settings. These anomalous areas are suggested as targets for future exploration works.
Individual and Combined Cardiometabolic Morbidities and the Subsequent Risk of Cardiovascular Events in Chinese Adults
Authors: Wang Jiao , Wang Zhimin , Guo Feng , Zhang Yinghui , Ji Hongfei , Chen Gang , Wan Qin , Yan Li , Wang Guixia , Qin Yingfen , Luo Zuojie , Tang Xulei , Huo Yanan , Hu Ruying , Ye Zhen , Shi Lixin , Gao Zhengnan , Su Qing , Mu Yiming , Zhao Jiajun , Chen Lulu , Zeng Tianshu , Yu Xuefeng , Li Qiang , Shen Feixia , Chen Li , Zhang Yinfei , Wang Youmin , Deng Huacong , Liu Chao , Wu Shengli , Yang Tao , Li Mian , Xu Yu , Xu Min , Zhao Zhiyun , Wang Tiange , Lu Jieli , Bi Yufang , Wang Weiqing , Ning Guang , Zhao Yanyan , Qin Guijun 
Published: August 2021

Abstract

Context
Diabetes, hypertension and dyslipidemia accelerates the incidence of cardiovascular disease (CVD) events. However, data regarding the association between main cardiometabolic morbidities such as diabetes, hypertension, and dyslipidemia and the subsequent risk of CVD events in Chinese adults are still limited.

Objective
To investigate the associations between individual and combined cardiometabolic morbidities and incident cardiovascular events in Chinese adults.

Methods
Baseline data were obtained from a prospective, nationwide, and population-based cohort study in China during 2011–2012. A total of 133 572 participants aged ≥40 years were included in the study. The main outcome measures were CVD events.

Results
Compared with participants without diabetes, hypertension and dyslipidemia, participants with only diabetes (hazard ratio [HR], 1.58; 95% CI, 1.32-1.90) or only hypertension (2.04; 1.82-2.28) exhibited significantly higher risk for CVD events, while participants with only dyslipidemia (0.97; 0.84-1.12) exhibited no significantly higher risk for CVD events. When analyzed collectively, participants with diabetes plus hypertension (HR, 2.67; 95% CI, 2.33-3.06), diabetes plus dyslipidemia (1.57; 1.32-1.87), and hypertension plus dyslipidemia (2.12; 1.88-2.39) exhibited significantly higher risk for CVD. Moreover, participants with the combination of diabetes, hypertension, and dyslipidemia exhibited the highest risk for CVD events (HR, 3.06; 95% CI, 2.71-3.46). Multivariable-adjusted HRs (95% CIs) for CVD associated with diabetes based on fasting glucose ≥7.0 mmol/L, oral glucose tolerance test 2-hour glucose ≥11.1 mmol/L, and hemoglobin A1c ≥6.5% were 1.64 (1.51-1.78), 1.57 (1.45-1.69), and 1.54 (1.42-1.66), respectively; associated with hypertension based on systolic blood pressure ≥140 mmHg and diastolic blood pressure ≥90 mmHg were 1.89 (1.76-2.03) and 1.74 (1.60-1.88), respectively; associated with dyslipidemia based on total cholesterol ≥6.22 mmol/L, low-density lipoprotein cholesterol ≥4.14 mmol/L, high-density lipoprotein cholesterol &lt;1.04 mmol/L, and triglycerides ≥2.26 mmol/L were 1.18 (1.08-1.30), 1.30 (1.17-1.44), 1.00 (0.92-1.09), and 1.10 (1.01-1.20), respectively.

Conclusion
Diabetes, hypertension and dyslipidemia showed additive associations with the risk of CVD events in middle-aged and elderly Chinese adults.
Changes in Circulating Kisspeptin Levels During Each Trimester in Women With Antenatal Complications
Authors: Abbara Ali , Al-Memar Maya , Phylactou Maria , Daniels Elisabeth , Patel Bijal , Eng Pei C , Nadir Rans , Izzi-Engbeaya Chioma , Clarke Sophie A , Mills Edouard G , Hunjan Tia , Pacuszka Ewa , Yang Lisa , Bech Paul , Tan Tricia , Comninos Alexander N , Kelsey Tom W , Kyriacou Christopher , Fourie Hanine , Bourne Tom , Dhillo Waljit S 
Published: August 2021

Abstract

Context
Antenatal complications such as hypertensive disorders of pregnancy (HDP), fetal growth restriction (FGR), gestational diabetes (GDM), and preterm birth (PTB) are associated with placental dysfunction. Kisspeptin has emerged as a putative marker of placental function, but limited data exist describing circulating kisspeptin levels across all 3 trimesters in women with antenatal complications.

Objective
We aimed to assess whether kisspeptin levels are altered in women with antenatal complications.

Methods
Women with antenatal complications (n = 105) and those with uncomplicated pregnancies (n = 265) underwent serial ultrasound scans and blood sampling at the Early Pregnancy Assessment Unit at Hammersmith Hospital, UK, at least once during each trimester (March 2014 to March 2017). The women with antenatal complications (HDP [n = 32], FGR [n = 17], GDM [n = 35], PTB [n = 11], and multiple complications [n=10]) provided 373 blood samples and the controls provided 930 samples. Differences in circulating kisspeptin levels were assessed.

Results
Third-trimester kisspeptin levels were higher than controls in HDP but lower in FGR. The odds of HDP adjusted for gestational age, maternal age, ethnicity, BMI, smoking, and parity were increased by 30% (95% CI, 16%-47%; P &lt; 0.0001), and of FGR were reduced by 28% (95% CI, 4-46%; P = 0.025), for every 1 nmol/L increase in plasma kisspeptin. Multiple of gestation-specific median values of kisspeptin were higher in pregnancies affected by PTB (P = 0.014) and lower in those with GDM (P = 0.020), but not significantly on multivariable analysis.

Conclusion
We delineate changes in circulating kisspeptin levels at different trimesters and evaluate the potential of kisspeptin as a biomarker for antenatal complications.
Population Numbers and Reproductive Health
Authors: Suvorov Alexander 
Published: August 2021

AbstractA recent study published in The Lancet predicts a remarkable drop in population numbers following a peak that will be reached by 2064. A unique feature of the upcoming population drop is that it will be almost exclusively caused by decreased reproduction, rather than factors that increase rates of mortality. The reasons for decreased reproduction are also unique, as, unlike previous centuries, limited reproduction today is hardly due to a shortage in resources. In other words, the predicted population drop is almost exclusively due to changes in reproductive behavior and reproductive physiology. Today, global changes in reproductive behavior are mostly explained by social sciences in a framework of demographic transition hypotheses, while changes in reproductive physiology are usually attributed to effects of endocrine-disrupting pollutants. This review outlines a complementary/alternative hypothesis, which connects reproductive trends with population densities. Numerous wildlife and experimental studies of a broad range of animal species have demonstrated that reproductive behavior and reproductive physiology are negatively controlled via endocrine and neural signaling in response to increasing population densities. The causal chain of this control system, although not fully understood, includes suppression of every level of hypothalamic-pituitary-gonadal cascade by hypothalamic-pituitary-adrenal axis, activated in response to increasing stress of social interactions. This paper discusses evidence in support of a hypothesis that current trends in reproductive physiology and behavior may be partly explained by increasing population densities. Better understanding of the causal chain involved in reproduction suppression by population density–related factors may help in developing interventions to treat infertility and other reproductive conditions.