bluuebunny/crossref_metadata_2025_split huggingface dataset:
The expression of POMC and AgRP in brain and kidney tissues at different stages of diabetic nephropathy rats
Authors: Liu Shasha , Da Jingjing , Li Jiayu , Dong Rong , Yuan Jing , Zha Yan 
Published: August 2021

Abstract

Objective
To explore the changes of proopiomelanocortin (POMC) and Agouti-Related Peptide (AgRP) expression in brain and kidney tissues under insulin intervention at different stages of diabetic nephropathy (DN) rats.

Methods
The male Sprague-Dawley (SD) rats of DN were treated with high-fat diet for 8 weeks and induced by intraperitoneally injection of streptozotocin (30 mg/kg) for one time. Then DN rats were also injected insulin subcutaneously at 2–5 U/(kg·24 h) from initiation of the streptozotocin. Kidney tissue, blood sample, and 24 h-urine were collected to detect the ratio of kidney/body weight, blood glucose and 24-h urinary albumin excretion rate at different stages (4, 8, 12, and 16 weeks). Immunohistochemistry assay was used to measure the expression of POMC and AgRP at different stages of DN rats.

Results
The DN rats were established successfully. With the progression of DN, blood glucose, 24-h urinary albumin excretion rate and kidney body weight ratio increased significantly, while decreased when insulin was injected. Immunohistochemistry showed that the expression levels of POMC were decreased gradually in brain and kidney tissues. Conversely, the expression of AgRP in kidney was highest at week 8 and then decreased gradually. The effect of insulin on normalizing POMC and AgRP expression in brain and renal tissues was also observed in DKD rats.

Conclusion
With the progression of DN, the expression of POMC and AgRP in kidney tissues was observed at different stages of disease, and their expressions were significantly normalized by insulin. The mechanism of in situ expression of POMC and AGRP in kidney to the progression of DN needs further investigations.
Simultaneous membranous nephropathy and diabetic nephropathy occurrence in a patient: A case report
Authors: Tian Binyao , Liu Nan , Xu Tianhua , Liu Xiaodan , Yao Li 
Published: August 2021

Abstract
Membranous nephropathy (MN) is the most common glomerular disease in adults and is constantly associated with the occurrence of nephrotic syndrome. While diabetic kidney disease (DKD) and diabetic nephropathy (DN), which often occur in diabetic patients, are considered as the major causes of end-stage kidney disease. Actually, MN often occurs in patients with diabetes mellitus (DM), but to obtain a clear differential diagnosis without a renal biopsy has become difficult. Here we report the case of a female diabetic patient who developed both MN and DN simultaneously.
Laparoscopic Retrieval of Abdominal Cysts in Sheep and Goat
Authors: Handoo Nida , Fazili Mujeeb , Gayas Mohmmad Abrar , Shah Riyaz Ahmad , Athar Hakim , Allaie Idrees Mehraj , Kashani Bisma , Mir Masood Saleem 
Published: August 2021

Abstract
The study was planned to evaluate the use of laparoscopy for the diagnosis and retrieval of abdominal cysts in sheep and goats. The abdominal cysts were located in 10 of 135 adult, healthy small ruminants by using ultrasonography (USG). Percutaneous Puncture-Aspiration-Injection-Reaspiration (PAIR) technique was used for six animals. Thirty animals, including four diagnosed with abdominal cysts by USG, were subsequently subjected to laparoscopy under diazepam sedation (0.1 mg/kg, IV) and lumbosacral epidural regional anesthesia using 2% lignocaine hydrochloride (1.0 ml/5 kg). The animals were restrained in dorsal recumbency and two-port paramedian laparoscopy was performed. Abdominal cysts were located in seven animals (one cyst/animal). The cysts were grasped carefully, lifted close to the abdominal wall, and evacuated percutaneously under laparoscopic vision. The collapsed cysts were then retrieved. In two animals enlarged ports were sutured, treated with an antibiotic and an analgesic, resulting in uneventful healing. Five cysts were nonparasitic, two were parasitic, one extracted from a sheep, and one from a goat. In conclusion, laparoscopy has higher diagnostic accuracy in detecting unattached abdominal cysts in sheep and goats compared to USG. It is also a reliable, minimally invasive, and safe procedure for cyst retrieval. However, a larger-scale study is necessary for ascertaining long-term complications and the recurrence rate.
Discontinuation of Eculizumab treatment after hematological remission in patients with atypical and drug-induced hemolytic uremic syndrome
Authors: Yeter Hasan H. , Derici Ulver , Arinsoy Turgay , Altok Kadriye , Erten Yasemin , Guz Galip 
Published: August 2021

Abstract

Introduction. The aim was to evaluate the effect of therapeutic plasma exchange (TPE) and eculizumab on hematological and renal survival in atypical hemolytic uremic syndrome (aHUS), and additionally, to examine the reliability of discontinuation of eculizumab treatment.

Methods. This was an observational and retrospective study of 18 patients diagnosed with aHUS.

Results. The median age of the study population was 30 (22–66) years. Four of 18 patients achieved hematological remission with the TPE alone. However, one patient died after three sessions of TPE. Eculizumab was used in 13 patients and no death was observed. One year after treatment, improved kidney function was observed in 2 of 3 (66%) patients for TPE and 5 of 9 (56%) patients for Eculizumab. We discontinued eculizumab treatment in 9 patients. One of the patients who had a C3 gene mutation experienced disease relapse after Eculizumab discontinuation. None of the patients who had drug associated aHUS developed disease relapse after Eculizumab discontinuation.

Conclusion. Eculizumab treatment is a life-saving therapy in aHUS. Treatment discontinuation may be considered at least six months after hematologic remission in patients who had stable renal function or no expectancy for renal survival. Moreover, drug-associated cases seem to tend not to develop disease relapse in the long term.
EDUKASI CARA MENJADI JUMANTIK MANDIRI UNTUK MENCEGAH DBD DI TENGAH PANDEMI COVID-19 PADA KADER POSYANDU DI DUSUN JETIS, BAKUNGAN, KARANGDOWO, KLATEN
Authors: Kusumawati Aisya , Ayu Ajeng Kusumaning , Saputri Anggita Mutiara , Putriadi Priska Bintang , Qurrohman Muhammad Taufiq , Dewi Noviana 
Published: August 2021

Penyakit demam berdarah dengue (DBD) merupakan salah satu masalah kesehatan masyarakat di Indonesia yang jumlah penderitanya cenderung meningkat dan penyebarannya semakin luas. Penyakit DBD merupakan penyakit menular yang terutama menyerang anak-anak. Penyakit DBD mempunyai perjalanan yang sangat cepat dan sering menjadi fatal karena banyak pasien yang meninggal akibat penanganannya yang terlambat. Kegiatan penyuluhan ini bertujuan untuk mengedukasi warga di Dusun Jetis, Bakungan tentang pencegahan Demam Berdarah Dengue. Dari hasil kegiatan, peserta bisa memahami materi dengan baik dan mereka merasa puas dengan materi yang telah disampaikan.
Kata kunci: DBD, Imunitas, Pencegahan
ABSTRACT
Dengue hemorrhagic fever (DHF) is a public health problem in Indonesia where the number of sufferers tends to increase and its spread is increasingly widespread. DHF is a contagious disease that mainly affects children. DHF, which travels very quickly and often becomes fatal because many patients die due to late treatment. This outreach activity aims to educate residents in Jetis , Bakungan about preventing Dengue Hemorrhagic Fever. From the results of the activity, participants can understand the material well and they feel satisfied with the material that has been delivered.
Keywords: DBD, Immunity, Prevention
PENGUATAN EKONOMI BUMDES LUBUK KERTANG MELALUI PEMETAAN POTENSI DESA SECARA PARTISIPATIF
Authors: Absah Yeni , Rini Endang Sulistya , Aulia Farid 
Published: August 2021

Pengurus BUMDes harus memiliki kemampuan memahami potensi desa, menyusun tata kelola yang baik dimulai dari rencana sumberdaya yang dibutuhkan, jenis usaha yang dikembangkan, proses pelaksanaan secara partisipatif, transparan dan akuntabel. Kondisi eksisting BUMDes Lubuk Kertang masih perlu pembenahan dari pemahaman potensi desa, tata kelola, pemilihan dan pengembangan jenis usaha yang dikelola BUMDes secara berkelanjutan.Metode dalam kegiatan ini adalah melalui sosialisasi kegiatan pelatihan penguatan ekonomi BUMDes Lubuk Kertang Melalui Pemetaan potensi desa secara partisipatif, pelatihan penguatan ekonomi BUMDes Lubuk Kertang melalui pemetaan potensi desa secara partisipatif, penguatan tata Kelola melalui pengembangan unit usaha BUMDes Lubuk Kertang, serta monitoring dan evaluasi. Hasil dari program kemitraan kepada masyarakat ini adalah kelompok mitra dapat meningkatkan kemampuan dalam mengelola BUMDes dengan memilih dan mengembangkan jenis-jenis usaha yang ada berdasarkan potensi sumberdaya lokal desa melalui pemetaan potensi desa secara partisipatif dalam melakukan tata kelola BUMDes yang baik dan benar, sehingga mampu bersinergi dengan Pemerintah Desa Lubuk Kertang dan masyarakat sebagai pelaku wirausaha desa.
Kata Kunci: Peningkatan Kemampuan, Tata Kelola, Potensi Desa, Pemilihan dan
Pengembangan Unit Usaha
ABSTRACT
Administrators must have the ability to understand the potential of the village, formulate good governance starting from the resource plan needed, the type of business developed, the implementation process in a participatory, transparent and accountable manner. The existing condition of BUMDes Lubuk Kertang still needs improvement from the understanding of village potential, governance, selection and development of types of businesses managed by BUMDes in a sustainable manner. The method in this activity is through the dissemination of training activities for economic strengthening of the Lubuk Kertang BUMDes through participatory mapping of village potentials, training on strengthening the economy of the Lubuk Kertang BUMDes through participatory mapping of village potential, strengthening governance through the development of the Lubuk Kertang BUMDes business unit, and monitoring and evaluation. The result of this partnership program with the community is that partner groups can improve their ability to manage BUMDes by selecting and developing existing types of businesses based on the potential of village local resources through participatory mapping of village potentials in carrying out good and correct BUMDes governance, so that they can work together. with the Lubuk Kertang Village Government and the community as village entrepreneurs.
Keywords: Capacity Building, Village Potential, Selection and Development Business Unit
PEDULI DAN TANGGAP ANAK JALANAN DI MASA PANDEMI COVID-19 DI PEKANBARU
Authors: Hotmauli Hotmauli , Fitri Imelda , Yusmaharani Yusmaharani , Anita Fenny 
Published: August 2021

Jumlah anak jalan di Indonesia menunjukkan angka yang memperihatinkan mencapai 135.983 jiwa dan Provinsi Riau tergolong tinggi mencapai 256 orang anak terlantar.Komunitas Bahu Jalanan (KBJ) merupakan salah satu komunitas sosial peduli anak jalanan yang ada di kota pekanbaru. Kegiatan pengabdian masyarakat ini bertujuan meningkatkan pengetahuan dan kesadaran anak jalanan tentang menggunakan masker, mencuci tangan, menjaga jarak untuk memutus mata rantai penularan penyakit corona.Program ini dilaksanakan selama 2 kali tanggal 24 Januari dan 29 April 2020 dalam bentuk penyuluhan kesehatan kepada anak jalanan dan KBJ dengan jumlah peserta sebanyak 20 orang yang diakhiri dengan Tanya jawab.Tim pengabdi mengharapkan partisipasi KBJ dalam melakukan pendampingan kepada anak jalanan untuk tetap disiplin menjaga kesehatan terutama selama pandemic covid-19.
Kata Kunci: Peduli, Tanggap, Anak Jalanan, Covid-19
ABSTRACT
The number of street children in Indonesia show an alarming number reaching 135.983 people and Riau Province is classified as high, reaching 256 neglected. Komunitas Bahu Jalanan (KBJ) is a social community that cares for street children in the city of Pekanbaru. This community service activity aims ti increase the knowledge and awareness of street children about using masks, washing hands, maintaining distance to break the chain of transmission of the corona disease. This program was implemented 2 time on January 24 th and April 29 th 2020 in the form of health education to street children and KBJ with a total of 20 participants ending with a question and answer. The service team hopes that KBJ’s participation in providing assistance to street children to remain disciplined in maintaining health, especially during the covid-19 pandemic.
Keywords: Care giving, Responsive, Street Children, Covid-19
PENERAPAN TEKNOLOGI BUDIDAYA IKAN LELE BIOFLOK SEBAGAI UPAYA PENINGKATAN PENDAPATAN MASYARAKAT DI DESA PANDAN ARANG, KABUPATEN OGAN ILIR
Authors: Rarassari Madyasta Anggana , Wijayanti Marini , Dwinanti Sefti Heza , Mukti Retno Cahya , Yonarta Danang 
Published: August 2021

Biofloc Technology (BFT) menjadi salah satu teknologi alternatif dalam akuakultur yang bertujuan untuk memperbaiki kualitas air dan meningkatkan efesiensi pemanfaatan nutrisi. Tujuan dari Pengabdian Kepada Masyarakat ini adalah untuk memperkenalkan dan memberikan informasi kepada masyarakat dan petani tentang budidaya ikan Lele dengan sistem bioflok. Kegiatan ini dilakukan di Desa Pandan Arang, Kabupaten Ogan Ilir dengan menggunakan metode pemberdayaan partisipati aktif kelompok pembudidaya ikan pada mitra yang diajak kerjasama dengan transfer ilmu dan teknologi, meliput beberapa tahapan yaitu: 1) Persiapan; 2) Penyuluhan pembuatan pakan dan budidaya ikan; 3) Pembuatan demplot dan pendampingan; 4) Evaluasi dan pembuatan laporan hasil kegiatan. Hasil yang didapat bahwa kegiatan budidaya ikan lele dengan menerapkan sistem bioflok memberikan hasil dapat memperbaiki kualitas air pada budidaya ikan lele, terutama dalam menurunkan nilai ammonia dalam media budidaya. Serta memberikan pertumbuhan optimal pada ikan lele dengan bobot mutlak 8,4 gram/ekor dan pertumbuhan panjang mutlak 8,6 cm/ekor.
Kata kunci: Biofloc Technology, Ikan Lele, Desa Pandan Arang, Budidaya Ikan
ABSTRACT
Biofloc Technology (BFT) is an alternative technology in aquaculture that aims to improve water quality and increase the efficiency of nutrient utilization. The purpose of this social dedication are to introduce and provide information to the public and farmers with biofloc system. This activity is carried out in Pandan Arang Village, Ogan Ilir District with an active participatory empowerment method for farmers fish in partners who are invited to collaborate with the transfer of knowledge and technology, covering several stages, 1) preparation; 2) counseling for feed and fish cultivation; creating demonstration plots and assistance; 4) evaluation and making reports on the results of activities. The results showed that catfish culture using the biofloc technology could improve water quality in catfish aquaculture, particularly in reducing the value of ammonia in the culture medium. As well as providing optimal growth in catfish witn an absolute weight of 8,4 gr and absolute length growth of 8,6 cm.
Keywords: Biofloc Technology, Catfish, Pandan Arang Village, Aquaculture
Розрахунок обсягу пам’яті відеореєстратора системи відеоспостереження
Authors: Дубина Олександр Федорович , Нікітчук Тетяна Миколаївна , Андреєв Олександр Володимирович , Чухов Владислав Вікторович , Морозов Дмитро Сергійович , Нікітчук Сергій Миколайович 
Published: August 2021

У статті проведено аналіз сучасних форматів відеостиснення, наведено та обґрунтовано алгоритм розрахунку необхідного обсягу накопичувача відеореєстратора для надання можливості зберігання даних системи відеоспостереження певний термін, наведено порядок вибору жорсткого диску з точки зору форм-фактора накопичувача, його енергоспоживання та швидкості обертання дискових пластин.
Під час проєктування сучасних систем відеоспостереження необхідно враховувати досить значну кількість чинників. Одними із основних є: тип відеокамер, їх кількість, формат відеостиснення, якість зображення, активність у кадрі, термін зберігання, надійність накопичувача. Перевагою системи відеоспостереження є можливість зберігання відеоданих на необхідний термін з можливістю їх перегляду. Як пристрій зберігання застосовуються SD-карта пам’яті на відеокамері, накопичувач у відеореєстраторі, хмарні технології. У статті розглядаються питання збереження даних на жорсткому диску відеореєстратора. На сьогоднішній день широкого застосування набули як аналогові, так і цифрові або IP-відеокамери, які відрізняються принципами формування відеосигналу і можливостями підключення до мережі. Кількість відеокамер визначається характеристиками і параметрами об’єкта, що охороняється. Кожна сучасна IP-відеокамера підтримує декілька форматів стиснення даних, які різняться за принципами дії, коефіцієнтом стиснення, якістю зображення, а для аналогових відеокамер стиснення проводиться у відеореєстраторі. Ці фактори у кінцевому підсумку впливають на необхідний загальний обсяг пам’яті відеореєстратора. Крім цього, значущим є забезпечення надійності накопичувача, особливо для спостереження за важливими об’єктами.
An Assessment of the Smart COVID-19 Approach to Lockdown and its Empirical Evidence
Authors: Ghaffar Abdul , Munir Mubbasher , Aziz Osama , Alhajj Rada , Sanaullah Asif 
Published: August 2021

COVID-19 is a new and contagious disease that has changed human lifestyle and habits globally according to the directions provided by the World Health Organization (WHO). Until some authentic remedy or vaccine becomes available, every country is providing instructions to its public to follow precautionary measures. These measures may include lockdown, social distancing, restricting movement, and educating public about COVID-19. Lockdown is the most applied and successful way to control the virus spread and it remains helpful in curtailing the spike. However, it adversely affects developing countries like Pakistan. All types of lockdown disrupt the life of the poor and the middle class. In this paper, an intelligent-smart approach is suggested for developing countries as against complete lockdown to handle the pandemic. This approach will show the long-term results needed for controlling COVID-19 without creating any major disturbance in the economy. In this paper, evidence based approaches were used to evaluate the short-term and long-term effects of the daily increasing number of cases of COVID-19 in Pakistan. The results showed that Sindh, which has the maximum number of COVID-19 cases, is better in implementing smart lockdown as compared to other administrative regions of Pakistan. As the risk of the second wave of COVID-19 is enhanced, it would be effective to continue the intelligent-smart approach with mild SOPs to avoid the disastrous effects of COVID-19 in the future.
Received Date: May 14, 2020, Last Received: December 10, 2020 Acceptance: December 25, 2020
Causality between Macroeconomic Indicators and Stock Market: An Econometric Analysis
Authors: Akbar Muhammad Imad ud Din , Butt Abdul Rauf , Chaudhry Ali Farhan 
Published: August 2021

We attempt to examine the causality between economic growth and stock market performance of Pakistan for the years 1992M01-2012M12. For this purpose, the test devised by Granger (1988) has been employed. The results reveal a bi-directional causality between economic growth and stock market performance of Pakistan proxied by Karachi Stock Exchange capitalization (KSECAP). Once this bidirectional causality is established, a system of simultaneous equations has been specified and estimated by 2SLS to find the impact of economic growth and selected macroeconomic indicators on the stock market of Pakistan. The estimated results lead to the conclusion that economic growth affects the stock market of Pakistan and vice versa. The implications of the study are of paramount importance, especially for the emerging economies. Hence, bearing in mind the role of macroeconomic indicators in the performance of stock market a better policy can be formulated to enhance the growth of capital markets that in turn will increase the economic growth of emerging economies such as Pakistan and vice versa.
Responding to Sexual Boundary Notifications: The Evolving Regulatory Approach in Australia
Authors: Gee Christine , Tonkin Anne , Gaby Sharon , Urh Veronika , Anderson Sarah , Hardy Matthew , Fletcher Martin 
Published: August 2021

ABSTRACT
A sexual boundary violation by a health practitioner has an immense impact on a patient, and the trust and confidence in the health care system and the health care regulator are negatively affected. The Australian Health Practitioner Regulation Agency (Ahpra) and the Medical Board of Australia (MBA) in 2017 commissioned an independent review in response to a specific high-profile case of multiple physician-patient* sexual boundary violations. In response to recommendations for process improvement, Ahpra and the MBA worked to transform the regulatory management of sexual boundary notifications.The purpose of this paper is to explore the structural and cultural changes that have been made to manage sexual boundary violation notifications and lessons learned through the process. Three factors — specialized decision-making, training for investigators and policy and cultural changes — were identified as key elements of the change process. Since the changes in 2017, the rate of immediate regulatory action taken in response to sexual boundary notifications has increased substantially, with a higher proportion of decisions resulting in suspension of a physician’s registration. Further work on the experience of those who are part of the notification process and supporting people to share their stories and experiences through the notification and tribunal process is ongoing.
EFEKTIFITAS SELF-MANAGEMENT PROGRAM DALAM MENGELOLA STRES BELAJAR SISWA DI SMA NEGERI 2 BANJARMASIN
Authors: Jannah Salawatil 
Published: August 2021

Tujuan penelitian ini adalah untuk mengetahui gambaran tingkat stres belajar sebelum dan sesudah diberikan konseling dengan teknik self-management program pada siswa kelas akselerasi, serta untuk mengetahui efektivitas teknik konseling ini dalam mengelola stres belajar siswa kelas akselerasi di SMA Negeri 2 Banjarmasin. Penelitian ini merupakan penelitian kuantitatif dengan menggunakan metode eksperimen yang dilaksanakan di SMA Negeri 2 Banjarmasin. Populasi dalam penelitian ini adalah siswa kelas X MIPA dan XI MIPA. Sampel pada penelitian ini diperoleh melalui kriteria inklusi dengan menggunakan teknik stratified sampling purposive yang berjumlah 10 orang. Teknik analisis data menggunakan rumus t-test. Berdasarkan pengujian dari data yang didapatkan thit > ttab (3,71 > 1,86) maka Ho ditolak, yang artinya ada perbedaan tingkat persentasi stres siswa sebelum diberikan konseling dengan menggunakan teknik self-management program dan sesudah diberikan konseling.