bluuebunny/crossref_metadata_2025_split huggingface dataset:
Behavioural Symptoms of Mental Health Disorder such as Depression among Young People using Instagram: A Systematic Review
Authors: Adeyanju Gbadebo Collins , Solfa Ron Patrick , Tran Thuy Linh , Wohlfarth Sophia , Büttner Jonas , Osobajo Oluyomi A. , Otitoju Afolabi 
Published: April 2021

Abstract
There is a growing debate on the linkage between social networking platforms and mental health disorder, such as depressive behaviour or depression. However, the relationship between Instagram use and depression or depressive behaviour has not been exhaustively examined. This review aims to examine these two variables. Only peer-reviewed journal articles that are published between October 2010 and December 2018 were sought in central and journal databases. Studies were selected based on predefined criteria and assessed for risk of bias and quality of evidence using GRADE. 1,856 studies were the outcome of the search, out of which 9 meets all eligible criteria. Of the 9 studies, three-quarter was published between 2017 and 2018, covering five continents: (North America: 3; Asia: 2; Australia: 2; South America: 1, Europe: 1). The final included studies broadly examined young Instagram users between the age of 19 and 35. The synthesis affirmed a linkage between Instagram and symptoms of depression or depressive behaviour. Variables that moderate this relationship are social comparison, self-esteem built on validation and approval of others, social media dependence, gender, negative or insufficient feedback, poor self-rated attractiveness, Instagram broadcasting and loneliness, younger users and risk of anxiety, and the number of strangers that users follow. There is a strong relationship between Instagram use and mental health disorders such as depression or depressive behaviour; however, no in-depth direct causality is proven yet. Further studies are needed to unravel the direct causality puzzles.
NR2F2-AS1 Suppressed Trastuzumab Effects on Esophageal Cancer By Inhibiting miR-4429 and miR-425-5p Expression Through Targeting IGF1R
Authors: Zhang Zhibin , Zhao Xu , Zhu Rui , Ren Hong 
Published: April 2021

Abstract
Aim:In this manuscript, we aimed to investigate the involvement of non-coding RNAs in mediating trastuzumab effects in EAC. Background: Scarce evidences supported that targeted drugs, like Trastuzumab, can be applied to esophageal adenocarcinoma patients (EAC). Objective: Evaluating the role and mechanism of NR2F2-AS1 in regulating Trastuzumab effects in EAC patients. Method: RNA sequencing to screen IGF1R related lncRNAs. qRT-PCR and western blot were used to evaluate the expression level of genes. CCK-8 was used to test the cell proliferation ability. Dual luciferase reporter gene assay and RNA pull-down were used for crosstalk evaluation. Results: NR2F2-AS1 was identified to be associated with HER2 expression by RNA sequencing and its expression related to worse prognosis and advanced T and N stage.NR2F2-AS1 expression induced by Trastuzumab through mediating H3K27ac. Furtherly, miR-4429 and miR-425-5p, which were predicted and proved to interact with NR2F2-AS1 and IGF1R, expressed lowly in esophageal cancer both in vivo and in vitro and suppressed cell viability. Most importantly, miR-4429 and miR-425-5p overexpression could increase trastuzumab’s inhibitory effect on cell viability. Conclusion: Trastuzumab has the potential to suppress EAC progression mainly in the presence of miR-4429 and miR-425-5p overexpression targeting HER2. However, Trastuzumab induces exosomal NR2F2-AS1 expression, which binds to miR-4429 and miR-425-5p to suppress their expression, resulting in the failure of trastuzumab treatment. Therefore, targeting exosomes might be a novel way to develop auxiliary drugs for trastuzumab in EAC.
FIN Junctionless Field Effect Transistor (FIN-JLFET) With Ground Plane For Surpassing Parasitic BJT Action
Authors: Kumar Bhaskar , Gupta Bharat , Singh Sangeeta , Kumar Pankaj 
Published: April 2021

Abstract
The leakage mechanism due to lateral band-to-band tunneling (L-BTBT) results in increased off state current and hinders the scaling of the junctionless transistor. The effect of L-BTBT on FIN shaped gate Junctionless field effect transistor (JLFET) with the ground plane (GP) in oxide has been investigated. The proposed device is simulated using 3-D Silvaco TCAD and shows that it can mitigate the L-BTBT and leads to efficient volume depletion which relaxes the requirements of ultra-thin silicon thickness and high workfunction of the gate electrode. The results show significantly reduced OFF-state current and high Ion /Ioff ratio even at scaled gate length beyond 10 nm along with the reduction in drain induced barrier lowering and threshold voltage roll-off . Thus, the proposed device shows better performance at sub-10 nm node.
The diagnostic performance of 18F-FDG PET/CT and MRI in differentiating benign and malignant ovarian tumors: an indirect comparative analysis
Authors: Hu Xianwen , Li Dandan , Liang Zhigang , Liao Yan , Yang Ling , Wang Rui , Wang Pan , Cai Jiong 
Published: April 2021

Abstract
Objective: To compare the value of Fluorodeoxyglucose positron emission tomography (FDG-PET)/computed tomography (CT) and magnetic resonance imaging(MRI) in differentiating benign and malignant ovarian tumors.Material and Methods: Retrieved the research on the diagnostic performance of MRI or 18F-FDG PET/CT in identifying benign and malignant ovarian tumors published in PubMed and Embase from January 2000 to January 2021. Two authors independently extracted the data of the characteristics of each study. If the data of the study report can be used to construct a 2X2 contingency table comparing 18F-FDG PET/CT and MRI, these studies were selected. The Quality Assessment of Diagnostic Accuracy Studies were used to evaluate the quality of the studies. According to the sensitivity and specificity of 18F-FDG PET/CT and MRI, forest plots is generated.Results：A total of 27 articles including 1118F-FDG PET/CT studies and 17 MRI studies on the differentiation of benign and malignant ovarian or accessory tumors were included for this meta-analysis. The pooled sensitivity and specificity for 18F-FDG PET/CT in differentiating benign and malignant ovarian tumors were 0.92 (95% CI, 0.86-0.96) and 0.86 (95% CI, 0.79-0.91), respectively, and the pooled sensitivity and specificity for MRI were 0.92 (95% CI: 0.89-0.95) and 0.85 (95% CI: 0.79-0.89), respectively.Conclusion：MRI and 18F-FDG PET/CT have the same diagnostic performance in the differential diagnosis of ovarian benign and malignant tumors. However, MRI is more worthy of clinical application because of its lack of radiation, shorter scanning time, and lower medical costs.
Serum miRNA-204-5p as a potential noninvasive biomarker for the diagnosis of endometrial cancer with sentinel lymph node mapping
Authors: Wu Cailiang , Zhou Xuexin , Li Jiayong , Xiao Ruiying , Yang Ye , Xin Haomin , Dai Lei , Zhu Yaping , Wu Sufang , Bao Wei 
Published: April 2021

Abstract
Background

Lymph node status is one of the most important prognosis factors in determining adjuvant treatment in endometrial cancer (EC). However, lymphadenectomy bears significant surgical and postoperative risks. The use of the sentinel lymph node mapping (SLNM) has emerged as an alternative method to complete lymphadenectomy in EC. There remains controversy surrounding the SLNM in high-risk disease and its false negative rate (3%). We previously identified miR-204-5p is tumor suppressor miRNA associated with lymph node metastasis in endometrial cancer tissues. Here, we report serum miR-204-5p in EC patients have potential early diagnostic value combined with sentinel lymph node mapping.
Methods

The relative expression levels of miR-204-5p were detected by quantitative RT-PCR in the serum of 52 EC patients (total SLNM), 20 benign ovarian cyst patients and 20 myoma patients. The miR-204-5p expression was also detected in endometrial cancer tissues by in situ hybridization.
Results

Our results showed that serum miR-204-5p expression was down-regulated in EC patients than that in the benign ovarian cyst or myoma patients (p < 0.01).In accordance with final pathological evaluation, positive SLN EC patients have a significant lower level of miR-204-5p compared with negative SLN EC patients. The area under the ROC curve of miR-204-5p was 0.923, 95% CI(0.847, 1.000), and the diagnostic value with a sensitivity of 87.2% specificity of 80.0%.
Conclusions

Lower miR-204-5p expression is associated with lymph node metastasis in these SLN(+) EC tissues, indicate that down-regulation of serum miR-204-5p in EC patients have potential early diagnostic value combined with sentinel lymph node mapping.
Comparative and Phylogenetic Analyses of Complete Plastomes of Aucuba (Garryaceae)
Authors: Chen Xiong , Fan Linyuan , Huang Jian , Zhou Guohua , Huang Yuan 
Published: April 2021

Abstract
Backgroud: Aucuba (Garryaceae), which includes approximately 10 evergreen woody species, is a genus endemic to East Asia. Their striking morphological features give Aucuba species remarkable ornamental value. Owing to high levels of morphological divergence and plasticity, species definition of Aucuba remains perplexing and problematic. Here, we sequenced and characterized the complete plastid genomes (plastomes) of three Aucuba species: Aucuba chlorascens, Aucuba eriobotryifolia, and Aucuba japonica. Results: Comparative analyses revealed that Aucuba plastomes are highly conserved in size, structure, gene content, and organization, and exhibit high levels of sequence similarity. We recommend 11 plastid DNA regions as potential DNA barcodes for species identification and genotyping of Aucuba germplasm. Phylogenetic reconstruction based on 71 plastid protein-coding genes from taxa encompassing a wide phylogenetic diversity in the lamiids strongly supported the sister relationship between Garryaceae and Eucommiaceae. Conclusion: Plastome tree revealed the monophyly of Garryales, offering plastid phylogenomic evidence for the acceptance of Garryales as outlined by the updated Angiosperm Phylogeny Group. Under a comparative framework within Garryales, we detected massive plastome arrangements between Aucuba and Eucommia. In summary, our study provides useful genomic resources for further study of the taxonomy, evolution, conservation, and exploitation of Aucuba species.
Title Health Priority-Setting For Overseas Development Assistance in Low-Income and Middle-Income Countries: A Comparative Case Study of Ethiopia, Nigeria and Tanzania
Authors: Kwete Xiaoxiao Jiang , Berhane Yemane , Mwanyika-Sando Mary , Oduola Ayo , Liu Yuning , Workneh Firehiwot , Hagos Smret , Killewo Japhet , Mosha Dominic , Chukwu Angela , Salami Kabiru , Yusuf Bidemi , Tang Kun , Zheng Zhi-Jie , Atun Rifat , Fawzi Wafaie 
Published: April 2021

Abstract
Background Priority setting process for the health care sector in low- and middle-income countries involves multiple agencies, each with their unique power, decision-making and funding mechanisms. Methods This paper developed and applied a new framework to analyze priority setting processes in Ethiopia, Nigeria, and Tanzania, from a scoping review of literature. Interviews were then conducted using a pre-determined interview guide developed by the research team. Transcripts were reviewed and coded based on the framework to identify what principles, players, processes, and products were considered during priority setting. Those elements were further used to identify where the potential capacity of local decision-makers could be harnessed. Results a framework was developed based on 40 articles selected from 6860 distinct search records. 21 interviews were conducted in three case countries from 12 institutions. Transcripts or meeting notes were analyzed to identify common practices and specific challenges faced by each country. We found that multiple stakeholders working around one national plan was the preferred approach used for priority setting in the countries studied. Conclusions Priority setting process can be further strengthened through better use of analytical tools, such as the one described in our study, to enhance local ownership and improve aid effectiveness.
Factors Influencing the Utilization of Community Cultural and Leisure Services for the Older Adults From The Perspective of Supply and Demand: Based on the Case of Shaanxi Province
Authors: Niu Qing , Zhang Chi , Yu Zhao , Zhang Sifeng 
Published: April 2021

Abstract
Background

Along with the increasing number of older adults in China, the demand for older adults services of China's aging population has been transformed and upgraded, and the demand for community cultural and leisure services of the older adults has become increasingly prominent. The research on the influencing factors of the utilization of community cultural and leisure services of the older adults can help improve the service effect and enhance the quality of life of the older adults. Based on Anderson's model, we constructed an analytical framework of the influencing factors of the utilization of community cultural and leisure services for the older adults from both the supply and demand sides, and then used Poisson regression method to empirically test the analytical framework based on the survey data of three cities in Shaanxi Province in 2019.
Results

The results found that supply-side factors significantly influenced the utilization of community cultural and leisure services by the older adults, mainly including service facility supply, service content supply, and service location accessibility; demand-side factors significantly influenced the utilization of community cultural and leisure services by the older adults, mainly including service acceptability, service satisfaction, and service need. The study also found that, unlike the results of previous studies, the use of community cultural and leisure services by older adults was not constrained by economic level.
Conclusions

Both supply-side factors and demand-side factors significantly affect the utilization of community spiritual culture services by the older adults. In strengthening and improving the supply of community cultural and leisure services, the previous "top-down" and "service-centered" approach should be changed to a "bottom-up" and "demand-centered" approach. In the past, the supply of community spiritual culture services should be changed from a "top-down" and "service-centered" approach to a "bottom-up" and "demand-centered" approach, and attention should be paid to the urban-rural differences in supply.
Facile Synthesis of Micro CuO Crystals for Li Ion Full Battery
Authors: Song Y.Z. , Liu Z.J. , Qi B.X. , Li Mengting , Xie Jimin , Song W.H. 
Published: April 2021

Abstract
One step facile synthesis of micro CuO crystals is carried out by hydrothermal method. The porous lithium foil/Li-graphite is used as the anode for CuO-Li ion full battery. The micro CuO crystals are characterized by scanning electron micro porousscopy, X-ray powder diffractometer, Fourier Transform infrared spectrometer, thermogravimeter and differential scanning calorimeter. The battery with porous lithium foil/graphite anode is tested by the galvanostatic current charge-discharge technology at higher current densities of 0.25～0.5 mA/cm2. The porous lithium foil-graphite anode can effectively improve the discharge capacity of the CuO crystal battery.
Altered N-/O-Glycosylation Sites On The Receptor-Binding Domain (RBD) in COVID-19 Are Related To Coronavirus Infection And Pathogenesis.
Authors: Wang Shiwei , Xiao Fan , He Lingling , Yang Junru , Wei Hongshan 
Published: April 2021

Abstract
Objective: To discuss the possible significances of N-Linked and O-Linked glycosylation on the RBD of COVID-19Methods: Amino acid sequences multiple alignments of RBD used Clustal Omega (v.1.2.4) using default parameters. Prediction of potential N-linked glycosylation sites by NetNGlyc 1.0 server. Prediction of potential O-linked glycosylation sites by NetOGlyc 4.0 Server.Result: COVID-19 Spike glycoprotein has 22 potential N-linked glycosylation sites and 3 O-linked glycosylation sites. 2 of 22 N-linked glycosylation sites distributed in RBD. None of the 3 O-linked glycosylation sites distributed in RBD, which is markedly different from SARS and other bat coronavirus using ACE2 as a receptor. Comparing with its close coronavirus, but which can’t use ACE2 as a receptor, the COVID-19 has little N- and O-linked glycosylation sites.Conclusion: we show the obvious differences in glycosylation sites in RBD between COVID-19 and other coronaviruses. We speculate that altered N-/O-glycosylation sites on RBD in COVID-19 are related to its infection and pathogenesis.
Gender Differences in Dietary Behaviours, Health-Related Habits and Prevalence of Non-Communicable Diseases: A Cross-Sectional Study in Botswana
Authors: Letamo Gobopamang , Keetile Mpho , Navaneetham Kannan , Medupi Keitumetse 
Published: April 2021

Abstract
Background

There is scanty information regarding sex or gender differences in health-related habits, NCD risk factors, and prevalence of NCDs in Botswana. The purpose of this study is to assess the influence of gender differences on health-related habits, weight status, common NCD risk factors, and on the prevalence of non-communicable diseases.
Methods

A cross-sectional, population-based survey called the Botswana STEPS Survey II which was conducted in 2014 based on people aged 15–64 years. The survey used a multi-stage cluster sampling methodology to arrive at nationally representative sample. As such during analysis of data, a complex sample module from SPSS was adopted to account for the multiple stages of sampling. The predicted probabilities of outcome variables were derived by controlling the covariates. A total sample size of 2947 participants aged 25–64 years were used in this study.
Results

The study results showed that a statistically significant high predicted percentage of men compared to women smoked tobacco (34.4%, 95% CI: 33.5–35.1 vs. 4.4%, 95% CI: 4.3–4.5). Men were also consistently engaging in heavy alcohol use and low consumption of fruit and/or vegetables, and these differences were statistically significant. On the other, physical inactivity among women was higher than men. Controlling other covariates, a higher predicted probability of women than men were overweight (28.7%, 95% CI: 28.6–28.8 vs. 18.3%, 95% CI: 18.0-18.6) and obese (25.8%, 95% CI: 25.4–26.2 vs. 10.2%, 95% CI: 9.9–10.5). Women are at the greater risk of developing NCDs compared to men since the adjusted prevalence of at least 3 common risk factors were more among women than men. A higher adjusted predicted prevalence of women than men suffered from hypertension (39.4%, 95% CI: 38.9–40.0 vs. 26.1%, 95% CI: 25.5–26.8).
Conclusions

Overall, the study observed that there were gender differences in health-related habits, malnutrition, NCD risk factors and NCD prevalence. Appropriate policies and programmes need to be adopted in order to urgently address the problem of NCDs.
Effect of Liquid Volume And Microflora Source On Degradation Rate And Microbial Community In Corn Stover Degradation
Authors: Wang Jingjing , Zhu Dan , Zhao Siqi , Xu Song , Yang Rong , Zhao Wei , Zhang Xiaoxia , Huang Zhiyong 
Published: April 2021

Abstract
Degradation is the bottleneck in the utilization of crop straw. In this paper, we screened the microbial consortia degrading corn stover from straw degrading consortia MC1 (M), sheep feces (Y), and mixtures of M, Y, and cattle feces (Q). The effects of microflora source and liquid volume (representing dissolved oxygen) on the microbial community and degradation rate of corn stover were investigated. The results showed that the degradation rate and cellulase activity of a 200 mL liquid volume (L2) were significantly higher than that of 100 mL (L1). Microflora source had a significant effect on bacterial and fungal diversity, composition and taxa. Q and Y had higher bacterial and fungal α-diversity than that of M. The degradation rate was significantly correlated with cellulase activity but not with microbial diversity. This indicated that liquid volume had a greater impact on degradation rate and lesser impact on microbial community than microflora source in corn stover degradation.
Are Calcium-Channel Blockers the Most Effective Anti-hypertensive Agent in Black Women With Hypertensive Disorders of Pregnancy? A Systematic Review
Authors: John Jeeva Reeba , Curry Gwenetta 
Published: April 2021

Abstract
BackgroundBlack women are four times more likely to die than White women due to complications during pregnancy or childbirth in the U.K. This cohort are also more prone to Hypertensive Disorders in Pregnancy (HDP). Outside of pregnancy, there are race based differences in the management of hypertension as Calcium-Channel Blockers (CCB) are more effective in reducing blood pressure in Black patients. It is unclear whether these differences in anti-hypertensive management extend to the management of hypertension in pregnancy. The primary objective was to address this gap in evidence by undertaking a systematic review of randomised control trials, where one treatment arm comprised of CCBs, investigating pharmacological management of HDP to assess whether CCBs are the most effective anti-hypertensive agent in Black pregnant women.MethodsThe following electronic databases were searched: MEDLINE and Embase. We used MeSH and free text terms in conjunction to increase sensitivity to potentially relevant studies. Inclusion criteria included: (1) study involved drug treatment of HDP; (2) study was of randomised control trial design; (3) one of the treatment arms involved CCBs (4) English full-text and (5) outcome data was stratified by race, and included Black women. Information regarding baseline participant data, type of anti-hypertensive, and clinical outcomes was extracted from each study.ResultsThis review highlighted four randomised control trials, which published race or ethnicity demographics, with only one trial that stratified HDP outcomes by ethnicity. ConclusionsThere is a lack of evidence to draw definite conclusions as to whether CCBs are the most effective anti-hypertensive agent for Black patients with HDP, highlighting the need for further research in this area. However, this review demonstrates some evidence to support the hypothesis that CCBs could be more effective in the management of HDP in Black patients and that Labetalol, which is the current first-line management of HDP, may not represent the gold standard of treatment in this cohort.