bluuebunny/crossref_metadata_2025_split huggingface dataset:
FORMULATION AND EVALUATION OF SUSTAINED-RELEASE PELLETS OF LORNOXICAM
Authors: AMIN MILIND J. , PATEL KEYUR S. , PATEL DEEPA R. , PATEL ZIL P. , BAJAG JAYANTI V. 
Published: July 2021

Objective: The aim of the study was to develop sustained release pellets of lornoxicam using Eudragit RLPO and Eudragit RSPO to reduce the dosing frequency.
Methods: The sustained release pellets of lornoxicam were prepared by extrusion–spheronization technique using Eudragit RLPO and Eudragit RSPO as release retardant polymers and microcrystalline cellulose as spheronizing agent. A 32 Full factorial design was applied to investigate the combined effect of the two independent variables i.e. concentration of Eudragit RLPO (X1) and concentration of Eudragit RSPO (X2) on the dependent variables, In vitro drug release at 1h (Y1), In vitro drug release at 4 h (Y2) and In vitro drug release at 12 h. (Y3).
Results: The optimized formulation (F0) show in vitro drug release 11.24±1.21 %, 43.69±1.28 %, 82.69±1.74 % and 100.24±1.56 % at 1 h, 4 h, 12 h and 24 h respectively. Drug excipients compatibility study by FTIR showed no interaction between drug and excipients. Eudragit RLPO and Eudragit RSPO had a significant effect on in vitro drug release.
Conclusion: From all parameters and experimental design evaluation, it was concluded that the drug release rate decreased with an increase the concentration of Eudragit RLPO and Eudragit RSPO. SEM Photomicrograph of pellets revealed that the surface was rough and the pellets were spherical shaped in nature. The in vitro release kinetics revealed higuchi model is followed and drug release is by anamolous diffusion.
TARGETING NUCLEAR FACTOR KAPPA B WITH CHELATED ZINC COMPOUNDS TOWARDS ANTICANCER DRUG DESIGN
Authors: K. NAGALAKSHMI , S. SHILA , L. INBATHAMIZH , A. THENMOZHI , P. RASAPPAN , P. T. SRINIVASAN 
Published: July 2021

Objective: The objective of the study was to analyse the target-ligand interactions between nuclear factor-κB (NF-κB) and chelated Zinc compounds and to explore the anticancer drug potential of these ligands by a bio computational approach.
Methods: Bioinformatics databases and tools were applied for the study. Three dimensional structure of the target NF-κB was retrieved from Protein Data Bank (PDB). The optimized structures of two chelated Zinc compounds, Zinc acetate and Zinc orotate were taken for docking studies with the target using docking tool AutoDock 4.2. Drug properties of the ligands were further assessed by Molinspiration server.
Results: Docking results as predicted by AutoDock and as visualized by PyMol viewer were effective for both the ligands. Comparatively, Zinc orotate showed minimum energy and more interactions with the target. Both the ligands satisfied the Lipinski’s rule of five with zero violations.
Conclusion: The findings emphasized the promising role of chelated Zinc compounds as potent drug candidates in anti-cancer drug design against NF-κB.
Hukum Vaksin MR: Teori Istihalah dan Istihlak versus Fatwa MUI
Authors: Abubakar Alyasa' , Abubakar Ali 
Published: July 2021

Measles and rubella are infectious diseases that cause very dangerous diseases throughout the world. Both diseases are incurable; can only be prevented by administering the MR (Measles Rubella) vaccine. However, in Indonesia, the implementation of vaccination for these two diseases did not run smoothly due to the circulation of information that the basic ingredients or the process of making vaccines involved elements of pigs. On that basis, the Indonesian Ulema Council issued Fatwa Number 33 of 2018 concerning the Use of Mr (Measles Rubella) Vaccine Products from SII (Serum Institute Of India) for Immunization which stipulates that "the use of vaccines that utilize pig elements and their derivatives is unlawful". The MUI equates the involvement of pork as the main ingredient and as a medium for making vaccines. This paper relates the fatwa to the prohibition of certain objects in the Qur'an, hadith, and interpretations made by scholars, especially related to the theory of istihālah (perfect change) and istihlāk (mixing). Both of these theories are used in the thought of the scholars of schools and at the present time, especially in objects that are changed through fermentation and synthetic processes, which can be called chemical engineering. Campak dan rubella merupakan penyakit infeksi yang mengakibatkan pernyakit sangat berbahaya di seluruh dunia. Kedua penyakit tidak dapat diobati; hanya dapat dicegah dengan pemberian vaksin MR (Measles Rubella). Namun demikian, di Indonesia, pelaksanaan vaksinasi untuk kedua penyakit ini tidak berjalan lancar karena beredarnya informasi bahwa bahan dasar atau proses pembuatan vaksin terlibat unsur babi. Atas dasar itu, Majelis Ulama Indonesia menerbitkan Fatwa Nomor 33 Tahun 2018 tentang Penggunaan Vaksin Mr (Measles Rubella) Produk dari SII (Serum Intitute Of India) untuk Imunisasi yang menentukan bahwa “penggunaan vaksin yang memanfaatkan unsur babi dan turunannya hukumnya haram”. MUI menyamakan keterlibatan unsur babi sebagai bahan utama dan sebagai media pembuatan vaksin. Tulisan ini mengubungkan fatwa tersebut dengan keharaman benda tertentu dalam al-Qur'an, hadis, dan penafsiran yang dilakukan para ulama, terutama terkait dengan teori istihālah (perubahan sempurna) dan istihlāk (percampuran). Kedua teori ini digunakan dalam pemikiran para ulama mazhab dan pada masa sekarang, terutama sekali pada benda-benda yang berubah melalui proses fermentasi dan sintetis, yang dapat disebut sebagai rekayasa kimiawi.
The Dynamics Of The Atmospheric Pollutants During The Covid-19 Pandemic 2020 And Their Relationship With Meteorological Conditions In Moscow
Authors: Chubarova N. Ye. , Androsova Ye. Ye. , Lezina Ye. A. 
Published: July 2021

The relationship between the dynamics of the atmospheric pollutants and meteorological conditions has been analyzed during the COVID-19 pandemic in Moscow in spring, 2020. The decrease in traffic emissions during the lockdown periods from March 30th until June 8th played an important role in the decrease (up to 70%) of many gaseous species and aerosol PM10 concentrations and in the increase of surface ozone (up to 18%). The analysis of the pollutant concentrations during the lockdown showed much smoother diurnal cycle for most of the species due to the reduced intensity of traffic, especially during rush hours, compared with that before and after the lockdown. The specific meteorological conditions with low temperatures during the lockdown periods as well as the observed smoke air advection have made a considerable contribution to the air quality. After removing the cases with smoke air advection the decrease in concentration of many pollutants was observed, especially in NOx and PM10. The analysis of Pearson partial correlation coefficients with fixed temperature factor has revealed a statistically significant negative correlation between the Yandex self-isolation indices (SII), which can be used as a proxy of traffic intensity, and daily concentrations of all pollutants, except surface ozone, which has a statistically significant positive correlation with SII caused by specific photochemical reactions. In situations with SII>2.5 more favorable conditions for surface ozone generation were observed due to smaller NOx and the higher O3 /NOx ratios at the same ratio of VOC/NOx. In addition, this may also happen, since during the Arctic air advection, which was often observed during the lockdown period, the growth of ozone could be observed due to the downward flux of the ozone-rich air from the higher layers of the atmosphere.
Gradedness of the set of rook placements in A

n−1
Authors: Ignatev Mikhail V. 
Published: July 2021

Abstract
A rook placement is a subset of a root system consisting of positive roots with pairwise non-positive inner products. To each rook placement in a root system one can assign the coadjoint orbit of the Borel subgroup of a reductive algebraic group with this root system. Degenerations of such orbits induce a natural partial order on the set of rook placements. We study combinatorial structure of the set of rook placements in An−

1 with respect to a slightly different order and prove that this poset is graded.
Conservative algebras of 2-dimensional algebras, III
Authors: Arzikulov Farhodjon , Umrzaqov Nodirbek 
Published: July 2021

Abstract
In the present paper we prove that every local and 2-local derivation on conservative algebras of 2-dimensional algebras are derivations. Also, we prove that every local and 2-local automorphism on conservative algebras of 2-dimensional algebras are automorphisms.
Actions of the additive group Ga
on certain noncommutative deformations of the plane
Authors: Kaygorodov Ivan , Lopes Samuel A. , Mashurov Farukh 
Published: July 2021

Abstract
We connect the theorems of Rentschler [18] and Dixmier [10] on locally nilpotent derivations and automorphisms of the polynomial ring A
0 and of the Weyl algebra A
1, both over a field of characteristic zero, by establishing the same type of results for the family of algebras

A
h

=

〈

x
,
y
|
y
x
−
x
y
=
h

(
x
)

〉

,

{A_h} = \left\langle {x,y|yx - xy = h\left( x \right)} \right\rangle ,

, where h is an arbitrary polynomial in x. In the second part of the paper we consider a field 𝔽 of prime characteristic and study 𝔽[t]-comodule algebra structures on Ah
. We also compute the Makar-Limanov invariant of absolute constants of Ah
over a field of arbitrary characteristic and show how this subalgebra determines the automorphism group of Ah
.
Using the PIV Techniques in the Expertise of Gas Explosions
Authors: Vlasin Nicolae Ioan , Găman George Artur , Ghicioi Emilian , Floarea Gheorghe Daniel , Șimon-Marinică Adrian Bogdan 
Published: July 2021

Abstract
Given the possibilities offered by PIV systems, it was considered appropriate to test them in the study of the formation of explosive atmospheres. In this sense, within the INCD INSEMEX Petroșani laboratories, a test stand was created subject to the conditions of applying PIV techniques. Thus, this stand was built of transparent materials, having the possibility to introduce, in the inner volume, the suspended particles and the combustible gas, being at the same time able to be sectioned by the light plane generated by a laser source and to provide the recording conditions using a CMOS camera. The physical experiments concerned both the situation of a normal atmosphere inside the test stand and the situations of the appearance of a fuel gas leak and an efficient source of initiation of the formed explosive atmosphere.
ANALISIS KAPASITAS SALURAN DRAINASE TAMAN CIBODAS TANGERANG
Authors: Supiono Tirto Wijaya , Sutandi Arianti , Kurniawan Vittorio 
Published: July 2021

Flood is a natural disaster which is caused by various factors and causes many losses. In Cibodas Park, Tangerang, especially Sangiang Jaya Village, it is recorded that it experiences flooding almost every year. This study aims to determine the factors that cause flooding in the area under study and provide a solution. The analysis carried out includes secondary and tertiary channels, which will be calculated by the Manning method to determine the discharge value of each channel, and then will be compared with the discharge value due to the maximum rainfall that occurs. Based on the calculation 36 of the 137 channels reviewed were not able to accommodate the discharge from rainfall that occurred during the 2 year return period. After analyzing it, it can be concluded that the flood in Taman Cibodas Tangerang, especially Sangiang Jaya Village, was caused by the lack of capacity of the existing channel to accommodate the discharge caused by the maximum rainfall. The solution for this is to redesign the existing channel, namely increasing the width and depth of the unsafe channel, as well as routine maintenance of the existing channel. ABSTRAKBanjir adalah sebuah bencana alam yang disebabkan oleh berbagai faktor-faktor dan menimbulkan banyak kerugian. Di Taman Cibodas Tangerang khususnya Kelurahan Sangiang Jaya tercatat mengalami banjir hampir pada setiap tahunnya. Penelitian ini bertujuan untuk mengetahui faktor penyebab terjadinya banjir pada daerah yang diteliti serta memberikan solusinya. Analisis yang dilakukan mencakup saluran sekunder dan tersier, yang akan dihitung dengan metode Manning untuk mengetahui nilai debit dari setiap saluran, dan kemudian akan dibandingkan dengan nilai debit akibat curah hujan maksimum yang terjadi. Berdasarkan perhitungan 36 dari 137 saluran yang ditinjau tidak mampu menampung debit dari curah hujan yang terjadi selama periode ulang 2 tahun. Setelah dianalisis dapat disimpulkan bahwa banjir di Taman Cibodas Tangerang khususnya Kelurahan Sangiang Jaya disebabkan oleh kurangnya kapasitas saluran eksisting untuk menampung debit yang disebabkan oleh curah hujan maksimum. Solusi untuk hal tersebut adalah melakukan desain ulang pada saluran yang ada yaitu memperbesar ukuran lebar dan kedalaman saluran yang tidak aman , serta pemeliharaan saluran yang ada secara rutin.
Improving Heat Transfer from Peltier Devices Used in an Atmospheric Water Generation
Authors: Summers Mark , Asiabanpour Bahram 
Published: July 2021

Present Atmospheric Water Generation (AWG) systems are useful for providing water in areas with limited water supplies. Many industrial AWG systems use VCR (vapor-compression refrigeration) to achieve a large amount of cooling to extract liquid water out of the air. These systems require large amounts of energy to operate, usually in the form of diesel or AC-powered generators. The systems also have many moving parts that require maintenance and use refrigerants that can leak and cause problems with the environment. An alternative AWG solution is to use DC-powered Peltier devices (thermoelectric coolers) to reduce the temperature of condensation plates to extract water from the air. This solution eliminates the issues with traditional industrial AWG systems since the Peltier devices are solid-state, have very long mean-time between failure (MTBF) performance, and can be powered by solar panels that eliminate the need to burn hydrocarbon-based fuels or have access to a reliable power grid. Also eliminated is the need to use chlorofluorocarbon (CFC) or hydrochlorofluorocarbons (HCFC) refrigerants that have been shown to deplete the ozone layer. This paper will present methods to improve the efficiency of the thermoelectric coolers by more efficiently extracting heat from the hot side of the device. This efficiency will be quantified by evaluating the coefficient of performance (COP) of the thermoelectric cooler under the various operating conditions. Different combinations of conductive heat transfer using aluminium heatsinks, convection heat transfer using forced airflow, and phase change heat transfer using copper heat pipes filled with distilled water will be investigated and evaluated.
Development of Aluminium Based Mango Seed Mangiferaindica Shell Ash (MSSA) Particulate Metal Matrix Composite
Authors: Ochuokpa Ezekiel Otor , Sumaila D. S. , Adebisi Abdulmumin 
Published: July 2021

A composite material is a combination of two or more chemically distinct and insoluble phases; its properties and structural performance are superior to those of the constituents acting independently. MMCs are made by dispersing a reinforcing material into a metal matrix to improve their properties. They are prepared by powder metallurgy and casting, although several technical challenges exist with casting technology. Achieving a homogeneous distribution of reinforcement within the matrix is one such challenge, and this affects directly on the properties and quality of composite. In this work a composite is developed by adding Mango seed shell Ash (MSSA) particulate in Al- Si-Mg Alloy by mass ratio 5%, 10%, 15% and 20%. The composite was prepared by stir casting technique. It is proposed to use this material for production of motorcycle wheel hub which are subjected to continuous wear as the hubs are in direct contact with the brakes and rotating sprockets. The MSSA, was characterized using X- ray fluorescent (XRF). The result reveals SiO2, has the highest percentage composition followed by CaO, Al2O3, Fe2O3 and Mg2O as major phases. The presents of these hard constituent compounds suggests that the mango seed shell ash can be used as particulate reinforcement in various metal matrices since the chemical composition has similarity with the XRF analysis of Periwinkle shell ash, rice husk, fly ash, and bagasse ash currently used in metal matrix composite. Mechanical tests such as hardness test and impact test were conducted. The results revealed that increase in the percentage of MSSA progressively increased the hardness of the material from 5% wt to a maximum hardness of 43.2 HV at 15% addition of MSSA. This represents a 26.16% improvement over the unreinforced alloy. However, the impact energy progressively decreases of the material from 5%wt of MSSA and later increased to optimum energy at 15% addition of MSSA. From the results it is concluded that composite material such as Al- Si-Mg/ MSSA is one of the options as a material for production of motorcycle hub. The wear test of the composite was then carried out using Taguchi design to optimize the range of MSSA from 5% wt -15% wt., Sliding speed of 5cm/s -20cm/s, sliding distance from 50m to 200m, and the load of 2N, 4N, 6N, & 8N respectively. Analysis of the result of SN ratio for wear rate shows the optimum wear resistant value is in the combination of Load=4N, sliding speed = 10cm/s sliding distance=200m and MSSA=15 wt% These also correspond with the analysis of wear maps & wear rate presented in the diagrams of dynamic friction coefficient (COF) for Al-Si- Mg/ MSSA Composite.
HUBUNGAN TINGKAT PARTISIPASI MASYARAKAT DENGAN DAMPAK EKONOMI LOKAL DALAM PENGEMBANGAN KAWASAN WISATA MANDEH
Authors: Vifian Rasyadi  , Fredian Tonny Nasdian  
Published: July 2021

Kekayaan sumber daya alam Indonesia menjadi peluang dalam meningkatkan perekonomian melalui sektor pariwisata. Partisipasi masyarakat diperlukan dalam pengembangan pariwisata guna meningkatkan dampak dan keuntungan yang dihasilkan dari pariwisata tersebut. Tujuan penelitian ini adalah menganalisis tingkat partisipasi masyarakat, menganalisis dampak ekonomi lokal, dan menganalisis hubungan antara tingkat partisipasi dengan dampak ekonomi lokal dalam pengembangan Kawasan Wisata Mandeh. Metode yang digunakan adalah metode survei dengan menggunakan pendekatan kuantitatif didukung data kualitatif. Pemilihan responden menggunakan teknik simple random sampling dengan jumlah responden sebanyak 30 orang dan pemilihan informan dilakukan secara sengaja. Hasil penelitian ini menunjukkan bahwa masyarakat Kampung Baru memiliki partisipasi yang tinggi dalam mengembangkan Kawasan Wisata Mandeh. Dampak ekonomi yang dirasakan pun tergolong tinggi, tetapi tidak berhubungan dengan tingkat partisipasi masyarakat Kampung Baru karena pihak yang paling berperan dalam pengembangan Kawasan Wisata Mandeh adalah pihak eksternal (pemerintah, pihak swasta, dan donatur).
Kata kunci: Keikutsertaan, kesejahteraan, pariwisata.
The Utilization of Family Planning Methods Among Rural Women In Ogun State, Nigeria
Authors: Oyewole Mojisola 
Published: July 2021

Family planning implies spacing and timing of child births. However, despite many actions put in place by government at all levels to sensitize citizen on the need for family planning; most Nigeria population still does not practice it as expected. Thus, the study assessed the utilization of family planning methods among rural women in Ogun State. Multistage sampling technique was used to select 120 respondents and structured questionnaire schedule was used for the data collection. Data collected were analysed using both descriptive and inferential analysis.Result shows that majority of the rural women had mean age of 33±10, 45.0% were Muslims, 57.5% had secondary education, 77.5% married, 50.0% traders, 39.1% had between 5 and 6 persons in their households, 42.5% earned between 35,001 and 60,000 monthly and 66.7% of the were member of social association. Also, 60.8% had low awareness of contraceptive methods. In addition, 56.7% had high knowledge of family planning methods, most of the rural women sourced information on family planning through television. Also, increase in weight experienced by the respondents were the health factors militating against the utilization of family planning methods by the rural women as 50.8% had high utilization of family planning methods used by the rural women. There was a significant relationship between member of social association (?2=4.268, p<0.05), awareness of contraceptive method utilize by rural women (r=0.761, p<0.05), knowledge (r=0.617, p<0.002), source of information (r=-0.119, p<0.05), factors (r=0.201, p<0.05) and level of utilization of family planning methods.It is therefore concluded that most of the women had high knowledge of family planning methods but only utilized the commons ones available to them. It is therefore recommended that educative trainings should be organized for the women to enhance their usage of other methods to ensure a secured child bearing.
Impact of Work From Home Policy on Behavior and Productivity of Lecturers and Education Staff
Authors: Sirait Afni , Murdianingrum Sri Luna 
Published: July 2021

Policy Work From Home (WFH ) is enforce within the FEB UPN "Veteran" Yogyakarta is one manifestation of breaking the chain of the COVID-19 virus. This research purpose is to identify the influence of WFH on the behavior and productivity of lecturers and education staff during this policy. This research is something new in education. The productivity assessment of the implementation of this policy has never be analyzed. This study uses quantitative methods with the number of respondents 96 respondents. The data was collected using a questionnaire, then tested the validity, reliability, and evaluation of the model structure using data analysis tools SmartPLS 3.0.0. The results of data processing explained that there was no relationship between WFH and technology-mediated behavior (P-Value = 0.297; T-Statistic = 1.043). A different yield of WFH data processing with productivity. It was found positive and significant influence but mediated partially competitive by technology. The path coefficient value of the direct relationship between WFH and productivity is 0.206 (P-Value 0.034; T-Statistic = 2.132) that the indirect relationship between WFH and productivity is mediating by the technology of 0.353. The limitation of this research is that it is only carried out in the FEB environment, not yet in a comprehensive manner at the “Veteran” National Development University, Yogyakarta.