bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for renal alterations in patients with hematological cancer undergoing antineoplastic treatment
Authors: Travassos Priscila Nunes Costa , Silva Paulo Goberlânio Barros , Freitas Milena Oliveira , Braga Marcus Davis Machado , Duarte Fernando Barroso , Maia Jéssica Karen de Oliveira , Pitombeira Helena , de Sousa Jacqueline Holanda , Alves Ana Paula Negreiros Nunes 
Published: May 2021

Abstract
Purpose Antineoplastic treatments, mainly chemotherapy, affect the kidneys, causing toxicity, and can trigger acute and long-term chronic kidney injury. The objective of this study was to analyze the prevalence of renal disorders in patients with oncohematological neoplasms under antineoplastic treatment. Methods This is a retrospective cohort study involving 75 patients affected by hematological cancer who underwent chemotherapy between 2012 and 2108 in the Hematology Sector of the Walter Cantídeo University Hospital of the Federal University of Ceará. Sociodemographic and clinical data, blood biochemical assessment, and Glomerular Filtration Rate (GFR) were analyzed using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. The data were tabulated, transferred to the Statistical Package for the Social Sciences software, version 20.0, and analyzed using Fisher's exact test or Pearson's chi-square test, followed by the Mann-Whitney test. Additionally, the variables were treated using a multinomial logistic regression model (p <0.05). Results The prevalence of renal disorders was 52.4%, considering the episodes of GFR through the CKD-EPI equation. There was an association between the reduction in GFR and the variables: female gender (p = 0.002), diagnosis of multiple myeloma (p = 0.008), start of treatment within 40 days (p = 0.005), protocol Cyclophosphamide, Oncovin, Prednisone (p = 0.026), Idarubicin (p = 0.032), Vidaza protocol, Dexamethasone, Cyclophosphamide (p <0.001), Zoledronate (p <0.001) and Pamidronate (p = 0.012). It was also observed that the Cancer and Leukemia Group B protocol (p <0.001) is inversely associated with a reduction in GFR. Conclusions The prevalence of renal disorders is high in the service evaluated, requiring periodic monitoring of the evaluation of renal function, since the reduction in GFR is statistically associated with different protocols used.
Theoretical Band and Confinement Interpretation of 1D Electrons: Impact on Plasmons and Exchange-Correlation Functionals
Authors: Sharma Akariti 
Published: May 2021

Abstract
Theoretical band and confinement interpretation of electron gas in lowest energy sub-band of quasi- 1D metallic wire have been done. Counter effects have been investigated on electrostatic oscillations (plasmons) determined by the electron density response function. Carrier correlations are treated by incorporating the local exchange-correlation (XC) effects within mean- field approximation. Results obtained are in quantitative agreement with experiments data of Nagao et al. (2006 Phys. Rev. Lett. 97 116802). Variation in both degeneracy and confinement potential cause a clear energy- shift in the electrostatic oscillations accomplished by asymmetry in band effective mass. Resultant massasymmetry is attributed to the greater strength of XC- effects. These contributions turns out to be quite logical in describing the splitting of 1D-bands over ad-hoc spin-orbital splitting idea of Nagao et al. Calculated XC-functionals agreed well with the lattice regularized diffusion Monte Carlo (LRDMC) simulation data (2006 Phys. Rev. B 74, 245427, 2009 J. Phys. A:Math.Theor.42 214021). Competition among XC-functionals and kinetic energy tendencies decides a criterion by satisfying which a metallic quasi-1D wire may undergo an instability at certain critical temperature (Tc).
Collider bias in administrative workers’ compensation claims data: A challenge for cross-jurisdictional research
Authors: Lane Tyler J 
Published: May 2021

Abstract
Purpose Workers’ compensation claims consist of occupational injuries severe enough to meet a compensability threshold. Theoretically, systems with higher thresholds should have fewer claims but greater average severity. For research that relies on claims data, particularly cross-jurisdictional comparisons of compensation systems, this results in collider bias that can lead to spurious associations and confound analyses. In this study, I use real and simulated claims data to demonstrate collider bias and problems with methods used to account for it. Methods Using Australian claims data, I used a linear regression to test the association between claim rate and mean disability durations across Statistical Areas. Analyses were repeated with nesting by state/territory to account for variations in compensability thresholds across compensation systems. Both analyses are repeated on left-censored data. Simulated claims data are analysed with Cox survival analyses to illustrate how left-censoring can reverse effects.Results The claim rate within a Statistical Area was inversely associated with disability duration. However, this reversed when Statistical Areas were nested by state/territory. Left-censoring resulted in an attenuation of the unnested association to non-significance, while the nested association remained significantly positive. Cox regressions on simulated data showed left-censoring can also reverse effects. Conclusions Collider bias can seriously confound work disability research, particularly cross-jurisdictional comparisons. Work disability researchers must grapple with this challenge by using appropriate study designs and analytical approaches, and considering how collider bias affects interpretation of results.
Response Mechanism of Metro Tunnel Structure under Local Collapse in Loess Stratum
Authors: Qiu Junling , Fan Feifei , Zhang Chengping , Lai Jinxing , Wang Ke , Niu Fangyuan 
Published: May 2021

Abstract
Due to the frequent occurrence of large-scale water inrush accidents in metro tunnels under the condition of local collapse of loess stratum, there are few reports on the response mechanism of loess metro tunnel under the condition of local collapse. Based on the actual project of tunnel water gushing in a certain section of Xi'an Metro Line 4, the research method of combining theoretical derivation with numerical simulation is adopted, the expressions of internal force and deformation of loess metro tunnel structure under different collapsibility conditions are derived and verified by finite difference method . The results show that the development of water transport channels and the law of collapsibility morphology of loess under local collapsibility are analyzed. Based on the elastic foundation beam model, the structural response model and analytical solutions of internal force and deformation of metro tunnel under different collapsibility conditions (upper collapsibility, side collapsibility and bottom collapsibility) are derived. Combined with the actual data of water inrush accident, the calculation case of the supporting project under the upper collapsible condition is analyzed. When the water head height is 7.5 m, the internal force and deformation of the tunnel structure only occur at about 20 m of the collapsible center. The internal force and deformation of the segment in the main influence range show an obvious non-linear trend, and the strong, weak and no influence zones are defined. Moreover, the numerical simulation results are consistent with the theoretical results under the supporting conditions, which verifies that the theoretical results can effectively predict the influence range of metro tunnel structure under local collapsibility of loess stratum. This research can provide new ideas for the construction, operation and disaster prevention of metro tunnels under the condition of local collapsibility in loess stratum.
LncRNA LINC00665 promotes ovarian cancer cell proliferation and inhibits apoptosis via targeting miR-181a-5p/FHDC
Authors: Wang Suli , Wang yingchun , Wang Jinhua , Lu Jin , Li Ke 
Published: May 2021

Abstract
Previous reports indicate that LINC00665, a lincRNA, which is a naturally occurring long intergenic non-coding RNA exerts vital effect in a variety of cancers. Herein, we explore the role of LINC00665 in ovarian cancer. RT-qPCR was taken into the experiment to determine the expression level of LINC00665. Cell Counting Kit-8 (CCK-8), flow cytometry, wound healing, transwell, and EdU are employed to evaluate the effect of LINC00665 on cell proliferation, apoptosis, and migration in SKOV-3 and OVCAR-3 cells. The axis of LINC00665 and its specific miRNA, the miRNA target gene is explored in dual-luciferase reporter assay. Firstly, we find that LINC00665 is upregulated in ovarian cancer cell lines. Furthermore, not only the cell viability and in SKOV-3 and OVCAR-3 was reduced by LINC00665 knockdown but also cell proliferation and migration were inhibited. Afterwards, the bioinformatics analysis suggested that LNC00665 specifically binds to miR-181a-5p. Then, several studies confirmed that LINC00665 downregulated the miR-181a-5p in SKOV-3 and OVCAR-3 cells. The knockdown of miR-181a-5p evidently reverses the inhibitory effect of sh-LINC00662. Besides, FH2 Domain Containing 1 (FHDC1) has been proved to deed as an effective target of miR-181a-5p. In conclusion, the knockdown of LINC00665 facilitates ovarian cancer via development by sponging miR-181a-5p and upregulating FHDC1 expression.
Extradural Glomus Tumor of the Thoracic Spine: Case Report and Literature Review
Authors: Zheng Jihui , Li Xinxing 
Published: May 2021

Abstract
Background: Glomus tumors are rare lesions that can arise anywhere along the spinal axis. Only thirteen cases have been reported. We report a case of a patient with a rare glomangioma of the thoracic spine. Following a review of the twelve previous cases is a discussion of a spinal glomus tumor with regard to clinical presentation, diagnosis, and treatment. Methods: A single, recent case arising from the extradural space of the thoracic spine is described, followed by a literature review of spinal glomus tumors.Results: Including our case, thirteen cases of a glomus tumor have been reported. The mean age at the time of diagnosis was 44.6 years (range: 22–73 years) and the male-to-female (M:F) ratio was 1.17:1. The lesion was located in the cervical spine in 1 patient, the thoracic spine in 7 patients, the lumbar spine in 4 patients, and the sacrum in 1 patient. All the tumors were benign; however, there was one report of local recurrence because of incomplete removal. There were no malignant transformations, metastases, or deaths reported with a mean follow-up of 20.09 ± 28.43 months (range: 2–90 months).Conclusions: Spinal glomus tumor are rare, and the preoperative diagnosis is difficult. An overwhelming majority of glomus tumors are benign and are cured by simple local excision. Patients undergoing complete resection have an excellent long-term prognosis.Trial registration: Not applicable.
Cancer immunoediting by melanocyte differentiation antigen-specific T cells determines response to immune checkpoint inhibition
Authors: Flatz Lukas , Ring Sandra , Pop Oltin , Poźniak Joanna , Berner Fiamma , Ali Omar , Abdou Marie-Therese , Diem Stefan , Bomze David , Niederer Rebekka , Fässler Mirjam , Landeloos Ewout , Rambow Florian , Bervoets Greet , Freiberger Sandra , Mayr Thomas , Muders Michael , Broek Maries van den , Bald Tobias , Lansdberg Jennifer , Dietrich Dimo , Mangana Joanna , Cozzio Antonio , Garbe Claus , Dummer Reinhard , Levesque Mitchell , Jochum Wolfram , Ludewig Burkhard , Bechter Oliver , Marine Jean-Christophe , Tüting Thomas , Hölzel Michael 
Published: May 2021

Abstract
T cells are critical in cancer immune surveillance but they can also shape tumor immunogenicity, described as cancer immunoediting. Melanoma patients commonly harbor T cells recognizing melanocyte differentiation antigens (MDAs). However, the roles of MDA-specific T cells in shaping melanoma immunogenicity and the response to immune checkpoint inhibition remain elusive. Here, we prospectively profiled peripheral CD8+ T cells from 27 stage IV patients before initiation of checkpoint inhibitor therapy. Clinical failure was associated with increased MDA-specific CD8+ T cells and reduced tumor MDA expression pretreatment. In nonresponders, decreased tumor MDA expression was concomitant with a dedifferentiated melanoma phenotype. We confirmed in 30 stage III patients that individuals with relapse disease during adjuvant anti-PD-1 therapy demonstrated a significantly higher incidence of dedifferentiated tumors pretreatment than individuals without recurrence. Thus, MDA-directed CD8+ T cells are associated with a dedifferentiated phenotype and reduced clinical response to checkpoint inhibitor therapy suggesting immunoediting as an important resistance mechanism.
Multi-level and Precise Evaluation of Slope Stability in Large Open-pit Mines: a Case Study at Dexing Copper Mine, China
Authors: Du Shigui , Saroglou Charalampos , Chen Yifan , Lin Hang , Rui Yong 
Published: May 2021

Abstract
As the mining industry developed significantly in the last decades and the depth of open-pit mining has increased, the stability of large open-pit slopes has become a major problem directly related to the safety production and development of a mine. However, the overall slope is indeed safer than the local slope based on the existing stability estimation methods. So the existing methods of directly analyzing the stability of the overall slope will produce some errors in the calculation results of the safety factor, and cannot comprehensively reflect the stability of the mine slope. Based on these problems, this paper adopted the idea of gradual analysis and the precise determination of discontinuity properties to perform a limit equilibrium analysis for the evaluation of mine slope stability. A case study slope, referred to as Yangtaowu Slope in Dexing Copper Mine, was selected for the demonstration of the accuracy of this approach. The results indicate that the adopted method can accurately reflect the actual stability of the slope, especially when the mine slope is near the critical state of stability.
Developing a theory-based behavior change intervention to improve the prescription of surgical prophylaxis in an Egyptian University Hospital.
Authors: Lohiniva Anna-Leena , Heweidy Iman , Abdu Samiha , Omar Abouelata , Ackley Caroline , Khairy Amr , Hassan ElZaher , Samir Shady , Talaat Maha 
Published: May 2021

Abstract
Background: Antimicrobial resistance (AMR) is increasingly pervasive due to multiple, complex prescribing and consuming behaviours. Accordingly, behaviour change is an important component of response to AMR. Little is known about the best approaches to change antibiotic use practices and behaviours. This project aims to develop a context-specific behaviour change strategy focusing on promoting appropriate prescription practices following the World Health Organization recommendations for surgical prophylaxis in an orthopaedic surgery unit in Egypt.Methods: The project included a formative qualitative research study was based on the Theoretical Domains Framework (TDF) to explore the determinants for inappropriate prescription of surgical antibiotic prophylaxis at an orthopaedic unit. The intervention was developed to following the Behaviour Change Wheel (BCW) in a knowledge co-production workshop with infection prevention and control experts that ensured that the theory based intervention was a culturally acceptable, practical and implementable intervention. Results: The prescription of surgical prophylaxis was influenced by five TDF domains including, knowledge, belief in consequences (mistrust towards infection prevention and control measures), environmental factors (lack of prescription guidelines) , professional role and reinforcement (a lack of appropriate follow up actions influenced prescription of surgical prophylaxis). The appropriate set of behaviour change functions of BCW and related activities to improve the current practices included education, enablement, persuasion, environmental restructuring and restriction. Conclusions The study showed that a theory based and context specific intervention can be created by using the TDF and BCW together with knowledge-co creation to improve the prescription of surgical prophylaxis in and Egyptian orthopaedic unit. The intervention need to piloted and scaled up.
A Cell-Based Subtractive Panning Strategy for Selection of Conformation-Specific Single-Chain Variable-Fragment (Scfv) Against Dimerization Domain of EGFR
Authors: Valadan Reza , Dabiri Mina , Tehrani Mohsen , Tabar Gholamreza Hashemi , Rafiei Alireza 
Published: May 2021

Abstract
Background and Objective:
Overexpression of the EGFR, from the ErbB receptor family, has been observed in several cancers and causes resistance to therapeutic antibodies, such as Herceptin. In this study, we produced a recombinant single-chain variable fragment (scFv) antibody against the EGFR dimerization domain.
Methods
The recombinant scFv was generated using a cell-based subtractive panning strategy. Subtractive panning was performed on genetically engineered VERO/EGFR cells and cancerous MDA-MB-468 cells. Phage cell-ELISA was used to monitor the binding of the selected scFvs to the dimerization domain of EGFR. Inhibition of EGFR and HER2 dimerization by the produced scFvs were finally evaluated using the dimerization inhibition test.
Results
PCR fingerprinting results showed a uniform digestion pattern following the third round of panning that confirmed the success of subtractive panning. Moreover, cell-ELISA validated the reactivity of the produced scFvs to EGFR after stimulation with EGF. The dimerization inhibition test showed the capacity of the scFvs to inhibit EGFR and HER2 dimerization.
Conclusions
Directed HER2 targeting showed to be more effective to target the functional domain of the cell receptor for the complete blockade of the intracellular signaling pathway. The subtractive panning strategy used in this study could control the process of directed selection of specific antibodies against the dimerization domain of EGFR. The selected antibodies might then be functionally tested for antitumor effects in both in vitro and in vivo studies.
A case-control Study on Blood Lipid Profile in Patients with COVID-19
Authors: Changaripour Shahab , Sarvazad Hosna , Barghi Maryam , Sajadi Elham , Sadeghian Mahdi Hashempour , Roozbahani Narges Eskandari 
Published: May 2021

Abstract
Background Dyslipidemia has been reported in patients with virus infections. This study was performed to evaluate the blood lipid profile in the patients with coronavirus disease 2019 (COVID-19), and exploring the underlying factors in its development and their predictive value for the severity of COVID-19.Methods In a case-control study, the lipid profile of patients with COVID-19 at the first admitted to two clinical centers in the west of Iran (July 2020 to Dec. 2020) and age- and gender-matched healthy people were explored. Three groups of controls, patients with the severe form of Covid-19 (admitted to the intensive care unit (ICU)), patients with Covid-19 with less intensity (outpatient admission), were defined for the subjects included in the study. The predictive values of different variables obtained from medical records for COVID-19 severity were analyzed.Results Generally, 48 outpatients and 49 ICU patients, including 70 men and 23 women with a mean age of 62.4±13.5 years, were included in the study. The control group consisted of 32 people, match sex and age with the patient groups. The mean triglyceride (TG) in the Covid-19 groups was higher than the control group, but there was no significant difference between them. The mean cholesterol in the patient groups was lower than the control group (p=0.001). The mean of low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) was significantly different in the patient groups; HDL-C in the ICU group was more than outpatient, and LDL-C in the outpatient group was more than ICU (P<0.05). LDL-C and HDL-C in the ICU group were less than the control group, but there was no statistically significant difference between the two mentioned groups. The frequency of diabetes and hypertension was higher in the ICU group than in the outpatient group (P<0.001). Furthermore, LDL-C level was associated with disease severity (odds ratio (OR): 0.966, 95% confidence interval (CI): 0.944-0.989, P= 0.004).Conclusion Lipid profiles in Covid-19 patients have different faces from healthy individuals. In the severe form, the lipid status has a different profile from the less severe form of Covid-19 disease. LDL-C level can be used as an indicator to determine the severity of Covid-19 disease.
Quantifying vanadium-vacancy clusters in V2O3 towards ultra-long cycling aqueous zinc-ion battery
Authors: Kefu Zhu , Wei Shiqiang , Shou Hongwei , Shen Fei-Ran , Chen Shuangming , Pengjun Zhang , Changda Wang , Yuyang Cao , Xin Guo , Luo Mi , Zhang Hongjun , Ye Bang-Jiao , Wu Xiaojun , He LunHua , Song Li 
Published: May 2021

Abstract
Defect engineering has been attracted widespread attention for promoting the stability of the electrodes. However, accurately quantifying and defining the effect of defects is extremely difficult. Here, the Rietveld analysis with combined neutron powder diffraction (NPD) and X-ray powder diffraction (XRD) patterns reveal vanadium defect (Vd) clusters in the V2O3 lattice up to 5.7% in aqueous zinc-ion batteries (ZIBs), further confirmed by positron annihilation spectroscopy (PAS) and synchrotron-based X-ray analysis. Benefitting from the Vd clusters, the V2O3 cathode achieves excellent cycle life with 81% capacity retention at 5.0 A g-1 after 30,000 cycles that is the most superb stable cathode for aqueous ZIBs at this current density. Besides, the density functional theory (DFT) calculations strongly indicate that the Vd clusters not only provide permanent sites for Zn2+ anchormen to enhance the integrity of V2O3 after the first discharging process, but also make Zn2+ de/intercalation in complex oxide, contributing collectively and effectively reducing the strong electrostatic interaction between host multivalent ions, resulting in the remarkable storage performance of Zn2+. This work highlights accurately quantifying and identifying the significant effect of defects for designing cathodes with ultra-long cycle life in future intelligent devices.
Characterization of Klebsiella pneumoniae isolated from patients suspected of pulmonary or bubonic plague during the Madagascar epidemic in 2017
Authors: Rakotondra Andriniaina , Andrianonimiadana Lova , Rahajandraibe Soloandry , Razafimahatratra Solohery , Andrianaivoarimanana Voahangy , Rahelinirina Soanandrasana , Crucitti Tania , Brisse Sylvain , Jeannoda Victor , Rajerison Minoarisoa , Collard Jean-Marc 
Published: May 2021

Abstract
Klebsiella pneumoniae can lead to a wide range of diseases including pneumonia, bloodstream, and urinary tract infections. During a short period of a plague epidemic in October 2017 in Madagascar, 12 K. pneumoniae isolates were identified in ten sputum and two buboes aspirate samples. These isolates were from 12 patients suspected of plague, without epidemiological relationships, but were negative for Yersinia pestis in culture. Data were collected from the plague national surveillance system. The isolates were characterized by antimicrobial susceptibility testing and whole-genome sequencing. Real-time PCR was performed to confirm the presence of K. pneumoniae DNA in buboes. All isolates were identified as K. pneumoniae sensu stricto. Five isolates were extended-spectrum β-lactamases producers; eight different sequence types were identified. Five isolates belonged to known hypervirulent sequence types. Our results demonstrate community-acquired pneumonia caused by K. pneumoniae isolates in patients suspected of plague, showing that plague epidemics can hide other etiologies.