bluuebunny/crossref_metadata_2025_split huggingface dataset:
CARDIOVASCULAR DISEASES AND HYPERTENSION: A POPULATION-BASED OBSERVATIONAL STUDY
Authors: Rigon Giulio , Albrigi Martina , Tebaldi Giacomo , Giontella Alice , Fava Cristiano , Minuz Pietro 
Published: April 2021

Abstract

Objective:
Overt cardiovascular diseases and diabetes mellitus occuring in the population of hypertensive subjects may be a related to the effectiveness of antihypertensive treatment. Aim of the study was to obtain information concerning drug utilisation, the clinical characteristics of hypertensive patients and blood pressure control in a large population.

Design and method:
We performed ad observational study aimed at defining prevalence of diabetes mellitus, heart failure, chronic kidney disease, atrial fibrillation previous myocardial infarction among hypertensive patients living in the province of Verona (approximately one third of the estimated total number). Information concerning antihypertensive treatment (the number of different drugs concomitantly prescribed over a period of 12 months among 13 drug categories), age, sex, blood pressure (categorical variable, cutoff 140/90 mmHg) was collected from their electronic records (database MySQL, Centro Studi FIMMG) by the 150 General Practitioners taking part in the study. Chi-square test was used in the subgroup analysis. Logistic regression analysis was performed to define which variables were independent predictors of blood pressure control.

Results:
The total number of studied hypertensives was 43526 (females 52.7%), 19.3% of them also had diabetes mellitus, 9.4% atrial fibrillation, chronic kidney disease, 2.9% heart failure and 2.2% a previous myocardial infarction. Data concerning blood pressure control in the previous 12 months was available for 26949 patients (females 51.%). By logistic regression analysis, predictors of inadequate blood pressure control were, not being treated (n = 2013), female sex, coexistent diabetes mellitus and chronic kidney disease (P < 0.0001). When only patient that could ben defined as resistant to medication were considered (uncontrolled blood pressure control with 3 drugs or treated with 4 drugs or more, n = 6472), the prevalence of diabetes mellitus (32.8%), atrial fibrillation (20.1%), heart failure (9.1%), chronic kidney disease (7.8%) myocardial infarction (4.4%) was higher than in patients treated (P < 0.0001).

Conclusions:
In a large part of the population of hypertensives blood pressure control is not achieved. Overt cardiovascular diseases or diabetes mellitus in hypertensive patients are associated with poor blood pressure control, independently of the number of prescribed drugs, suggesting a vicious circle that could result in worsening of organ damage.
HYPERTENSION- A REAL WORLD SETTING ANALYSIS
Authors: Mihailescu Anamaria , Balahura Ana Maria , Japie Cristina , Weiss Emma , Bartos Daniela , Badila Elisabeta 
Published: April 2021

Abstract

Objective:
Hypertension (HTN) represents a public health problem and blood pressure (BP) control rates have remained poor worldwide leading to an increasing number of hospital admission. The purpose of the current study is to describe the pattern of anti-HTN drug therapy in the Department of Internal Medicine of a tertiary care emergency hospital.

Design and method:
We retrospectively analysed all the charts of patients admitted for HTN in the Internal Medicine department of a tertiary care emergency hospital during 3 months (August-October 2019). We retrieved demographic, clinical and treatment approach data from the charts of patients presenting for HTN defined as

JOURNAL/jhype/04.03/00004872-202104001-00695/inline-graphic1/v/2024-05-29T151720Z/r/image-tiff

. We compared different characteristics between female patients (FM) and male (ML) patients.

Results:
69 patients admitted for HTN in 3 months (4.64% from all admissions), 43 female patients (62.3%) mean age 65.51±1.41. The FM, when compared with ML, were more frequently older, with a higher mean systolic BP with the same mean diastolic BP. The calcium channel blockers were more frequently use in female than in their male counterparts, the same use of angiotensin-converting-enzyme inhibitors (ACEi), angiotensin -receptor-blockers (ARB), Loop diuretics and beta blocker was preferred as antihypertensive drug medication in male. See table.

Conclusions:
Hypertensive disease remains one of the main causes for hospital admission. Patients are more frequently women, have an advanced age, a higher systolic blood pressure making them more likely to have a more severe clinical picture. ACEI, CCB, and beta blocker are the preferred antihypertensive therapy. The number of patients with HTN is the expected to rise with the increase life expectancy if a correct antihypertensive therapy is not applied.
DYSLIPIDEMIA IN TREATED AND UNTREATED PATIENTS WITH HYPERTENSION, DIABETES OR BOTH
Authors: Miao Chaoying , Zhang Wei , Liu Changyuan , Wang Jiguang 
Published: April 2021

Abstract

Objective:
We investigated the prevalence of dyslipidemia in patients with hypertension and diabetes mellitus alone or both and the association between dyslipidemia and the use of antihypertensive and antidiabetic agents.

Methods:
Our study participants were treated and untreated hypertensive and diabetic patients enrolled in a China nationwide registry. Dyslipidemia was defined as a serum concentration of triglycerides ?2.3 mmol/L, total cholesterol ?6.2 mmol/L, low-density lipoprotein (LDL) cholesterol ?4.1 mmol/L and high-density lipoprotein (HDL) cholesterol ?1.00 mmol/L.

Design and method:
Serum triglycerides and HDL cholesterol, but not total and LDL cholesterol were significantly different between patients with hypertension alone (n = 860), diabetes alone (n = 473) or both (n = 1090). The prevalence of dyslipidemia was not significantly different between patients with hypertension and diabetes or both for either component or overall (P = 0.34), except that in the subgroup younger than 50 years of age. It was higher in patients with hypertension and diabetes than those with either disease alone. However, treated, compared with untreated hypertensive patients had significantly lower serum total, LDL and HDL cholesterol, and similar serum triglycerides. And treated, compared with untreated diabetic patients had significantly lower serum triglycerides, total and LDL cholesterol but similar HDL cholesterol. The result remained similar for various forms of dyslipidemia. After adjustment for confounding factors, the results were confirmatory, with a significantly odds ratio of 0.76 (95% CI 0.58 - 0.997, P = 0.048) for hypercholesterolemia and 1.56 (95% CI 1.19 - 2.03, P = 0.001) for low HDL cholesterol associated with antihypertensive treatment, and of 1.50 (95% CI 1.18 - 1.89, P = 0.0008) for low HDL cholesterol associated with antidiabetic treatment. Further analyses showed that the odds for low HDL cholesterol was significantly (P?0.02) higher with the use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (n = 927), diuretics/?-blockers (n = 547) and insulin (n = 460).

Results:
The prevalence of dyslipidemia was only sightly different between patients with hypertension and diabetes mellitus alone or both, but differed significantly between treated and untreated hypertension and diabetes in favour of treatment in spite of some compromise in HDL cholesterol with the use of some of medications.
NEGLECT OF HYPERTENSION AND HYPERLIPEMIA DURING MEDICAL HISTORY INQUIRY NEED MORE CONCERN
Authors: Ma Zhiyi , Chen Yuanyuan , Sun Ningling 
Published: April 2021

Abstract

Objective:
The neglect of hypertension and hyperlipemia is a further question while their awareness rates are increasing. Our observation is to estimate the neglect rate of hypertension and hyperlipemia for diagnosed patients during outpatient service.

Design and method:
In 2019, from May 06th to Nov 19th, we collected medical history inquiry information during outpatients service in cardiovascular department in our hospital. Patients inclusion criteria: those for symptoms or diseases. Patients exclusion criteria: those only for routine prescription. Initiative-providing-hypertension-history patients (IPHH) were defined as initiatively providing hypertension history during disease history inquiry. Passive-providing-hypertension-history patients (PPHH) were defined as providing antihypertension therapy during medication history inquiry without providing hypertension history. Initiative-providing-hyperlipemia-history patients (IPLH) were defined as initiatively providing hyperlipemia history during disease history inquiry. Passive-providing-hyperlipemia-history patients (PPLH) were defined as providing lipid-lowering therapy during medication history inquiry without providing hyperlipemia history. (see Table)

Results:
1. There were 459 hypertension patients among total 883 patients. IPHH patients were 412 and the complaints of 198 patients among them were hypertension unrelated. All the complaints of 47 PPHH patients were hypertension unrelated. The percentage of PPHH patients among hypertension patients without hypertension related complaints was 19.18%. 2. There were 245 hyperlipemia patients among total 883 patients. IPLH patients were 122 and the complaints of 92 patients among them were hyperlipemia unrelated. All the complaints of 123 PPLH patients were hyperlipemia unrelated. The percentage of PPLH patients among hyperlipemia patients without hyperlipemia related complaints was 57.21%. 3. The percentage of PPLH patients among hypertension patients without hyperlipemia related complaints was 19.73% (89/451). 4. The age of PPHH patients was significantly younger than that of IPHH patients without hypertension complaints (p = 0.023322). 5. PPHH patients had a higher female percentage than IPHH without hypertension complaints, but there was no statistical significance (p = 0.05365). (see Table)

Conclusions:
We need pay more attention to medication history inquiry to avoid omitting hypertension and hyperlipemia history. Particularly for application in artificial intelligence, man-machine conversation in the area of medicine should design the feedback from medication history inquiry to disease history inquiry.
HIGH BLOOD PRESSURE SCREENING DURING MAY MEASUREMENT MONTH (MMM) 2019: TIME FOR ADOLESCENTS?
Authors: Lopez-Sublet Marilucy , Ghouiles-Zeblah Sabrina , Benramedane Ghouti , Hahashy Jean -Kyrellos , Rouabhi Aicha , Gourara Helene , Mouterde Anne Laure , Benainous Ruben , Leprieur Benedicte Giroux , Suhl Jaehyo , Foudi Farid , Litout Marylene , Le Jeune Sylvain , Dhote Robin 
Published: April 2021

Abstract

Objective:
Every year, may 17th is dedicated to the World Hypertension Day (WHD). This is an initiative of the World Hypertension League, an affiliate of the International Society of Hypertension. These united forces have expanded to make May Measurement Month (MMM), a month of campaigning to raise awareness against hypertension. The objective of this study was to introduce the data obtained from a sample of adults and adolescents during the 2019 WHD.

Design and method:
Screening was conducted at a French hospital (Hôpital Avicenne) with the voluntary and volunteer assistance of physicians, interns, pharmacy and nursing students of our service, while following the standard MMM protocol. The support of the French Society of Hypertension (in partnership with Omron France) has been proposed to provide our centre with blood pressure (BP) monitors (Omron HEM-FL31/M3 Comfortâ).

Results:
Anonymous general data for this population of 140 subjects, including 66 adolescents, are summarized in the table. The majority of adult participants reported that their last BP measurement was more than a year ago, or was never even taken. All adolescents had measured their BP for the first time during this campaign. The number of known hypertensive adults 15 (20,3%). No adolescents were known to have high BP.
In this population, 10 (13,5%) adults and 3 (4,5 %) adolescents have an unknown high normal BP. As for new hypertensive patients, there are 6 adults (8,1%) and 4 adolescents (6,1%) broken down as follows: Grade 1 hypertension: 4 adults and 4 adolescents, Grade II: only 2 adults, and Grade III: no one.

Conclusions:
Hypertension in children and adolescents is underestimated and under-diagnosed in clinical practice. European and American guidelines tend to simplify adult hypertension classifications to apply it in adolescents, but data from intervention and screening trials are not yet available. Although our screening approach remains modest in France (or at the European level), it aims to place young people at the centre of screening actions. A sustainable and methodical model for hypertension screening campaigns must make it possible to involvement the future generations in the fight against cardiovascular risk.
PREVALENCE AND PREDICTION OF SECONDARY HYPERTENSION IN YOUNG MALE MILITARY PERSONNEL
Authors: Kim Kihyun , Kim Jong-Youn , Choi Eui-Young , Kwon Hyuck Moon , Rim Se-Joong 
Published: April 2021

Abstract

Objective:
Current guidelines suggest screening for secondary causes in the early onset of hypertension (HTN) before 30 years. However, there have been few studies on secondary HTN in young adults. We aimed to investigate the prevalence and predictors of secondary HTN in young male military personnel.

Design and method:
This study used data from the Defense Medical Information System (DEMIS) database between January 2011 and June 2017. Of 6373 hypertensive males (19–29 years) from 19 military hospitals in South Korea, we comprehensively reviewed the medical records of 638 cases with any diagnosis associated with secondary HTN.

Results:
Secondary HTN was confirmed only in 140 subjects (2.2%) as a final diagnosis through detailed chart review. The most common causes were polycystic kidney disease (0.74%) and renal parenchymal diseases (0.38%). Other endocrinologic causes were very rare. The independent predictors for secondary HTN were abnormal thyroid function test (odds ratio [OR], 9.50; 95% confidence interval [CI], 4.84 to 19.45; P < 0.001), proteinuria (> trace) (OR, 6.13; 95% CI, 2.97 to 12.99, P < 0.001), hematuria (> trace) (OR, 4.37; 95% CI, 2.15 to 9.01; P < 0.001), severe HTN (>180/110 mmHg) (OR, 3.07; 95% CI, 1.42 to 6.65; P = 0.004), and overweight (body mass index > 23 kg/m2) (OR, 0.33; 95% CI, 0.19 to 0.59; P < 0.001). However, there were no significant differences in the family history of HTN, headache, total cholesterol level and diabetic state between primary and secondary HTN.

Conclusions:
Secondary HTN is very rare in young male military personnel. To ensure cost-effectiveness, screening for secondary HTN should be performed selectively considering various predictive factors.
GENETICALLY, DIETARY SODIUM INTAKE IS CAUSALLY ASSOCIATED WITH SALT-SENSITIVE HYPERTENSION RISK IN A COMMUNITY-BASED COHORT STUDY: A MENDELIAN RANDOMIZATION APPROACH
Authors: Choi Jung Ran , Jeong Seongmun , Kim Jae-Yoon , Cho Youngbum , Kim Namshin 
Published: April 2021

Objective:
Excessive dietary salt intake is associated with an increased risk of hypertension. Salt sensitivity, i.e., an elevation in blood pressure in response to high dietary salt intake, has been associated with a high risk of cardiovascular disease and mortality. We investigated whether a causal association exists between dietary sodium intake and hypertension risk using Mendelian randomization (MR).

Design and method:
We performed an MR study using data from a large genome-wide association study comprising 15,034 Korean adults in a community-based cohort study. A total of 1,282 candidate single nucleotide polymorphisms associated with dietary sodium intake, such as rs2960306, rs4343, and rs1937671, were selected as instrumental variables. The inverse variance weighted method was used to assess the evidence for causality.

Results:
Higher dietary sodium intake was associated with salt-sensitive hypertension risk. The variants of SLC8E1 rs2241543 and ADD1 rs16843589 were strongly associated with increased blood pressure. In the logistic regression model, after adjusting for age, gender, smoking, drinking, exercise, and body mass index, the GRK4 rs2960306TT genotype was inversely associated with hypertension risk (OR = 0.356, 95% CI = 0.236–0.476). However, the 2350GG genotype (ACE rs4343) exhibited a 2.11-fold increased hypertension risk (OR = 2.114, 95% CI = 2.004–2.224) relative to carriers of the 2350AA genotype, after adjusting for confounders. MR analysis revealed that the odds ratio for hypertension per 1 mg/day increment of dietary sodium intake was 2.24 in participants with the PRKG1 rs12414562 AA genotype.

Conclusions:
Our findings suggest that dietary sodium intake may be causally associated with hypertension risk.
DETERMINANTS FOR THE DEVELOPMENT OF HYPERTENSION AMONG INDONESIAN ADULTS: A PROSPECTIVE COHORT STUDY
Authors: Mashuri Yusuf Ari , Ng Nawi , Santosa Ailiana 
Published: April 2021

Objective:
Hypertension is one most important contributors to disability, morbidity and all-cause mortality. The prevalence of hypertension is predicted to increase over time, not least in Indonesia. However, there is no longitudinal study investigating the factors determined the incidence of hypertension in Indonesia. This study aimed to assess the factors associated with the development of hypertension among adult Indonesian population.

Design and method:
This study used longitudinal data from the Indonesian Family Life Survey study (IFLS-4 and IFLS-5) consisting of individuals aged 15 years and over. We followed respondents who did not have hypertensive at the baseline during a 7-year follow-up period. Mixed method analysis was used to examine the determinants associated with the development of hypertension, controlling for sociodemographic, smoking behaviour, body mass index, and mental health status and socioeconomic status. The principal component analysis was conducted to construct the socioeconomic index

Results:
Out of the total 18,342 individuals who were followed up, 5,449 individuals (29.7%) were developed hypertension. The annual incidence rate of hypertension was 235.9 per 10,000 individuals. Being older, widow/divorcee, former smoker and had BMI > 25 kg/m2 were significantly associated with the development of hypertension (p < 0.05). Men had higher odds of developing hypertension compared to women (OR = 1.17, 95% CI = 1.02–1.34). In contrast, BMI < 18.5 kg/m2 (OR = 0.62, 95% CI:0.51–0.75) and in the 2nd tertile of mental health (OR = 0.83, 95% CI: 0.75–0.92) were protective factors for developing hypertension. While socioeconomic status, education level, working status, and residence area were not significantly associated with the development of hypertension.

Conclusions:
This study highlights the high burden of hypertension among Indonesian adults. Understanding factors associated with the development of hypertension in Indonesia setting helps to create a comprehensive preventive health program. Findings from this study suggest the need for strategic programmes and health policies for reducing the burden of hypertension regardless of any socioeconomic condition.
STUDY OF THE EUROPEAN SOCIETY OF HYPERTENSION ON BLOOD PRESSURE CONTROL IN ESH EXCELLENCE CENTERS (BP CON ESH) - THE FIRST PRELIMINARY REPORT
Authors: Jelakovic Bojan , Triantafyllou Areti , Doumas Michael , Kalaitzidis Rigas , Protogerou Athanase , Kallistratos Emmanouil , Stergiou George , Moloberti Alessandro , Giannattasio Cristina , Marketou Maria , Papadakis Ioannis , Papadopoulos Dimitrios , Pengo Martino , Parati Gianfranco , Sarafidis Pantelis , Stojanov Vesna , Triantafyllidi Eleni , Manta Eleni , Tsioufis K. , Agabiti-Rosei Enrico , Kreutz Reinhold , Polonia Jorge , Januszewicz Aandrzei , Mancia Giuseppe 
Published: April 2021

Objective:
To determine the BP control and identify associated global and local risk factors in ESH Excellence centers.

Design and method:
The first 4 consecutive adult patients coming to the visit in an Excellence center on a particular day who fulfill inclusion/exclusion criteria and singed informed consent were enrolled. Structured questionnaire was applied, BP and heart rate were measured using the same validated device with appropriate cuff. In centers with capability to perform unattended BP measurements (Omron HEM-907 XL) both methods were done in a random sequence. Body weight, height and waist circumference, laboratory data, ABPM and ECG done in past 3 months and BP values from medical records were entered into the eCRF.

Results:
After the start in 12/2018 from overall 189 ESH Excellence centers, 80 centers (42.3%) from 24 different countries agreed to participate. Currently, 29 centers (36.3%) from 11 countries (45.8%) enrolled their patients. Patients’ demographics and clinical characteristics are shown in Table 1, and average BP and heart rate values are presented in Table 2.

Conclusions:
This first interim analyses confirmed the feasibility of conducting BP CON ESH study among ESH Excellence centers. The preliminary data for attended BP measurements indicated mean BP values above the recommended targets in the 2018 ESC/ESH guidelines.
IMPACT OF INTERVENTIONAL TECHNIQUES IN HYPERTENSIVE PATIENTS
Authors: Ali Muhammad , Shaheen Sumera 
Published: April 2021

Objective:
These co morbidities such as metabolic diseases and kidney problems could not only alter the course of circulatory system but also may be the major reason behind the epidemiological association with hypertension because of systemic changes leads to potential nephropathic toxic risk which directly relate to hypertension. Proper identification of metabolic disorder is very important for suitable management and treatment of hypertension and its related disease. Heart problem, obesity and unhealthy diet and life style also contribute in high prevalence of hypertension in Pakistan. Social habits also link to high prevalence of hypertension. There for, current study based on different factors which associate to hypertension and their treatment.

Design and method:
The descriptive, interventional study was carried out at various hospitals and clinics. The samples were enrolled via purposive sampling method. The duration o f study was 02 years. The total number of control patients were 500 and 500 were of case patients in which interventional techniques were applied based on JNC VIII guidelines.

Results:
Out of total patients, 78.4% of the patients were under the category of sedentary lifestyle. 22.8% hypertensive patients with 30–39 kg/m2 were observed. The interventional technique was applied and results were assessing based on JNC VIII guidelines. In adding, contribution through patients, query along with follow up calls, recommend some additional education, and varying of therapy or dose, can be assist out the Patient as well as ultimately direct to an add to in drug compliance and disease situation upgrading. The significant value were come less than 0.5.

Conclusions:
Post interventions results show that patients upgraded their practice significant improvement of positive attitudes by intermittently checking their blood pressure level, lipid profile, control smoking habit, maintain their life styles and disease management of hypertension in patients.