bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vascular plants occurrences in Dokdo Islands, Korea, based on herbarium collections and legacy botanical literature
Authors: Chang Chin-Sung , Kwon Shin Young , Shin Hyun Tak , Jung Su-Young , Kim Hui 
Published: December 2021

The vascular flora of the Dokdo Islands has been reported, based on primary collections made in 2012 and 2013 and legacy botanical literature. The Dokdo Islands are the remotest islands of Korea, located in the East Sea approximately 87 km from Ulleungdo Islands. They comprise two main volcanic islands, Dongdo (east islands) and Seodo (west islands) and minor islets surrounding the two main islands. This research was conducted to document vascular plant species inhabiting Korea's most inaccessible islands. We present a georeferenced dataset of vascular plant species collected during field studies on the Dokdo Islands over the past seven decades.
In the present inventory of the flora of Dokdo, there are listed 108 species belonging to 78 genera and 39 families, including 93 native species and 15 newly human-induced naturalised species for these Islands' flora. The Poaceae and Asteraceae families are the most diverse, with 22 and 15 taxa, respectively. Some of the previously-listed taxa were not found on Dokdo probably because they are rare and the limited time did not allow collectors to find rare species. The spread of introduced species, especially the invasive grass Bromus catharticus Vahl., affects several native species of Dokdo flora.
Design and evaluation of pharmacological properties of a new 1,3,4-thiadiazolylamide derivative of 2-propylpentanoic acid
Authors: Malygin Alexandr S. , Yasnetsov Victor V. 
Published: December 2021

Introduction: The use of the pharmacophoric approach is a promising direction for modifying the chemical structure of 2-propylpentanoic (valproic) acid in order to obtain new drugs.
Materials and methods: In the experiments on mice, acute toxicity, neurotoxicity, antiepileptic activity and analgesic effect of N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-propylpentanamide (valprazolamide) were evaluated. LD50 was determined by probit analysis. Neurotoxicity was determined in a rotarod test and a bar test in mice. The effects of valprazolamide on the exploratory behavior of mice in open field test and in a light/dark transition test were evaluated. Its antiepileptic activity was tested in mice against seizures induced by maximal electroshock, pentylenetetrazole(scPTZ); isoniazid, thiosemicarbazide, pilocarpine, and camphor. The analgesic effect was studied in a hot plate test.
Results and discussion: N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-propylpentanamide was obtained by introducing pharmacophores into the structure of 2-propylpentanoic acid: a substituted amide group and an electron-donor domain of 1,3,4-thiadiazole. The LD50 value for intraperitoneal administration of a new 2-propylpentanoic acid: derivative to mice was 924.8 mg/kg, and the TD50 value in the rotarod test and the bar test were 456.7 mg/kg and 546.7 mg/kg, respectively. The suppression of orienting responses in the animals was noted when it was administered in neurotoxic doses. Valprazolamide showed the most antiepileptic activity on models of MES, scPTZ and isoniazid antagonism tests. The ED50 values were 138.4 mg/kg, 74.5 mg/kg, and 126.8 mg/kg, respectively. The therapeutic indices for these models of epilepsy were 6.7; 12.4; 7.3, and protective index – 3.3; 6.1 and 3.6, respectively. In the hot plate test, valprazolamide increased the latency period before a defensive response to a thermal stimulus (ED50 165 mg/kg).
Conclusion: N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-propylpentanamide is a new 1,3,4-thiadiazolylamide derivative of 2-propylpentanoic acid with antiepileptic and analgesic activities, which belongs to the group of low-toxic agents.
Impact of organotin compounds on the growth of epidermoid Lewis carcinoma
Authors: Dodokhova Margarita A. , Safronenko Andrei V. , Kotieva Inga M. , Alkhuseyn-Kulyaginova Margarita S. , Shpakovsky Dmitry B. , Milaeva Elena R. 
Published: December 2021

Introduction: Search for new compounds with a broad antitumor and antimetastatic potency due to multiple targeting remains important in medicinal chemistry, pharmacology and oncology. We report the efficacy of hybrid organotin agents bis-(3,5-di-tert-butyl-4-hydroxyphenylthiolate) dimethyltin (Ме3) and (3,5-di-tert-butyl-4-hydroxyphenylthiolate) triphenyltin (Ме5).
Materials and methods: The compounds were administered to mice bearing the spontaneously metastatic epidermoid Lewis lung carcinoma (LLC). The efficacy of the treatment was evaluated by mean life span, percentage of tumor growth inhibition, number of lung metastases, frequency of metastasis, tumor weight 21 days after tumor cell inoculation, and a degree of lung damage according to the method of D. Tarin and J.E. Price.
Results and discussion: For new organotin compounds containing an antioxidant protective fragment of 2,6-di-tert-butylphenol, moderate antitumor and pronounced antimetastatic effects were revealed in the Lewis model of epidermoid lung carcinoma; more active for Me5. Some features of the development of the process of metastasis were recorded with the introduction of various doses of hybrid organotin compounds.
Conclusion: Substances Ме3 and Ме5 possess specific activity on the model under investigation, which allows one to suggest these organotins as promising series of antitumor and antimetastatic agents with multiple targeting mode of action.
Fluid-Shifting Technique for Preventing Argentinian Flag Sign
Authors: Coassin Marco , Mori Tommaso , Antonini Marco , Di Zazzo Antonio , Bonini Stefano , Kohnen Thomas 
Published: December 2021

PURPOSE:
To present a novel technique to prevent Argentinian flag sign in intumescent white cataracts.

METHODS:
Surgical technique.

RESULTS:
After puncturing the anterior lens capsule, the liquefied cortical material is easily shifted from the retronuclear space to the anterior chamber by gently injecting viscoelastic above the mid periphery of the anterior capsule (not inside the bag). After depressurizing the intracapsular forces, capsulorhexis can be safely completed.

CONCLUSIONS:
This is a convenient strategy when at risk of observing Argentinian flag sign during the removal of mature cataracts.

[
Journal of Refractive Surgery Case Reports.
2021;1(3):e45–e46.]
Enfermagem em nefrologia
Authors: Alcântara Alencar Melo Geórgia , Fernandes de Oliveira Caio Victor , Fernandes Pereira Francisco Gilberto , Lins de Alencar Filho Wellington , Gomes de Melo Diogo , Borges de Morais Jamine , Áfio Caetano Joselany 
Published: December 2021

Objetivo: compreender as percepções de enfermeiros especialistas em nefrologia quanto às competências necessárias para o cuidado a pessoas com injúria renal aguda.
Método: estudo qualitativo, realizado com seis enfermeiros especialistas em nefrologia, tendo como técnica o grupo focal,com a questão norteadora:fale sobre suas percepções quanto às competências necessárias ao enfermeiro que cuida de pessoas com insuficiência renal aguda. Os áudios foram gravados, transcritos na íntegra e submetidos à análise de conteúdo. Resultados: emergiram três categorias: conhecimento fisiopatológico da lesão renal aguda como estratégia de prevenção e cuidados na pré-diálise; operacionalização e gerenciamento de máquinas durante a terapia dialítica e dificuldades para operacionalização do cuidado com transferência de responsabilidade de cuidados aos técnicos em enfermagem.
Conclusão: conhecimento fisiopatológico da injúria renal aguda, habilidade no manuseio de máquinas, intervenção nas intercorrências, atenção acurada aos exames, cuidados com aspectos nutricionais e manejo de cateteres são as principais competências necessárias para operacionalização do cuidado. No entanto, a fragilidade da legislação a este público dificulta a operacionalização do cuidado com segurança.
PENGENALAN UNIT PENANGGULANGAN KEADAAN DARURAT DI BANDARA BAGI SISWA SMK PENERBANGAN DI WILAYAH LAMPUNG DAN SIDOARJO
Authors: Kalbuana Nawang , Hendra Oke , Rizkina Aswia Pangsa , Lestary Dwi , Kardi Kardi , Solihin Solihin 
Published: December 2021

PKP-PK unit is an emergency response unit at the airport whose location is within the air-side area that not everyone can enter. The community around the airport and many vocational aviation students have not received comprehensive information related to this PKP-PK Unit. This Unit has a vital role, especially at the time of the accident at the airport. Community Service Activities (PKM) is one of the activities of Tridharma Higher Education that the academic community must carry out at the Polytechnic of Aviation Indonesia Curug. Because it is still in the pandemic condition, Covid-19 PKM activity is done through Webinar with Zoom. This webinar activity was attended by Vocational Aviation Students in Lampung and Sidoarjo regions in collaboration with Karang Taruna Sedati Gede Sidoarjo village, East Java. After this activity is completed, it is expected that it will increase the knowledge and insight of the students of SmK Flight regarding emergency management units at the airport.
Giá trị của siêu âm bơm nước buồng tử cung trong chẩn đoán khối choán chỗ buồng tử cung ở bệnh nhân hiếm muộn
Authors: Võ Hữu Bình , Hồ Ngọc Anh Vũ , Phan Thị Ngọc Minh , Lê Tiểu My , Phạm Thị Phương Anh , Vương Thị Ngọc Lan 
Published: December 2021

Mục tiêu: Xác định độ nhạy, độ đặc hiệu, giá trị tiên đoán dương, giá trị tiên đoán âm của SIS trong chẩn đoán khối choán chỗ buồng tử cung ở bệnh nhân hiếm muộn.
Phương pháp: Nghiên cứu thử nghiệm chẩn đoán dọc tiến cứu. Bệnh nhân nữ hiếm muộn có chỉ định phẫu thuật nội soi do nguyên nhân vòi trứng, u buồng trứng, lạc nội mạc tử cung, khối choán chỗ buồng tử cung được nhận vào nghiên cứu. Bệnh nhân được thực hiện SIS trong vòng 1 tháng trước ngày nội soi, kết quả được mù với bác sĩ phẫu thuật. Tiêu chuẩn vàng chẩn đoán khối choán chỗ buồng tử cung là giải phẫu bệnh lý hay nội soi buồng tử cung.
Kết quả: Từ tháng 7/2015 đến tháng 3/2016, có 433 bệnh nhân được nhận vào nghiên cứu. Tỉ lệ có khối choán chỗ buồng tử cung được ghi nhận là 49,6%, (polyp nội mạc tử cung là 45,7% và nhân xơ tử cung dưới niêm là 3,9%). Siêu âm bơm nước buồng tử cung có độ nhạy là 87% và độ đặc hiệu là 85% trong chẩn đoán polyp nội mạc tử cung và 78% và 98% trong chẩn đoán nhân xơ tử cung dưới niêm mạc. Phân tích đa biến cho thấy kích thước polyp nội mạc tử cung theo kết quả SIS là yếu tố độc lập liên quan đến độ chính xác trong chẩn đoán khối choán chỗ buồng tử cung.
Kết luận: Siêu âm bơm nước buồng tử cung có giá trị chẩn đoán tốt đối với khối choán chỗ buồng tử cung với độ nhạy và độ đặc hiệu lần lượt cho chẩn đoán polyp nội mạc tử cung và nhân xơ tử cung dưới niêm là 87%, 85% và 78%, 98%. Thực hiện SIS cho bệnh nhân hiếm muộn trước nội soi giúp định hướng cho bác sĩ và tư vấn cho bệnh nhân trước phẫu thuật nhằm chủ động hơn cho xử trí trong quá trình phẫu thuật.
So sánh thai diễn tiến cộng dồn giữa chuyển phôi ngày 3 so với chuyển phôi ngày 5 ở bệnh nhân thụ tinh trong ống nghiệm
Authors: Hà Thị Diễm Uyên , Nguyễn Ngọc Quỳnh , Phạm Dương Toàn , Huỳnh Gia Bảo , Hồ Mạnh Tường 
Published: December 2021

Mục tiêu: Đánh giá tỷ lệ thai diễn tiến cộng dồn của chuyển 2 phôi ngày 3 so với chuyển 2 phôi ngày 5 nhằm xác định chiến lược chuyển phôi tốt nhất cho các bệnh nhân đến thực hiện thụ tinh trong ống nghiệm.
Đối tượng và phương pháp nghiên cứu: Nghiên cứu đoàn hệ hồi cứu được thực hiện tại IVFMD, bệnh viện Mỹ Đức trong thời gian từ tháng 7 năm 2014 đến tháng 6 năm 2015. Tiêu chuẩn nhận bệnh: tuổi từ 18 - 42 tuổi, kích thích buồng trứng bằng GnRH antagonist, số chu kỳ điều trị thụ tinh trong ống nghiệm ≤ 2, số phôi hữu dụng ngày 3 (loại I và II) ≥ 8, chuyển 2 phôi ngày 3 hoặc ngày 5. Tiêu chuẩn loại: Các chu kỳ trưởng thành noãn trong ống nghiệm (IVM), chu kỳ xin-cho trứng, kích thích trưởng thành noãn bằng GnRH agonist.
Yếu tố đánh giá kết quả chính: tỷ lệ thai diễn tiến cộng dồn và yếu tố phụ: tỷ lệ làm tổ, tỷ lệ đa thai, tỷ lệ sảy thai, tỷ lệ thai ngoài tử cung. Kết quả: 210 bệnh nhân thỏa điều kiện được chọn vào nghiên cứu được chia làm 2 nhóm với 78 bệnh nhân thực hiện chuyển phôi vào ngày 3 và 132 bệnh nhân chuyển phôi ngày 5. Không có sự khác biệt đáng kể giữa 2 nhóm bệnh nhân về các thông số độ tuổi, BMI, thời gian vô sinh, độ dày nội mạc tử cung (32,2 so với 31,9; 21,3 so với 21,2; 4,3 so với 4,3; 11,8 so với 11,9; tương ứng với mỗi nhóm). Tỷ lệ thai diễn tiến ở các trường hợp chuyển phôi ngày 5 cao hơn đáng kể có ý nghĩa thống kê so với chuyển phôi ngày 3 (29,5% so với 46,2%; P=0,02). Tỷ lệ thai diễn tiến cộng dồn không có sự khác biệt đáng kể giữa 2 nhóm chuyển phôi ngày 3 và ngày 5 (60,3 so với 71,2; P>0,05).
Kết luận: Mặc dù tỷ lệ thai diễn tiến ở trường hợp chuyển phôi ngày 5 là cao hơn đáng kể so với chuyển phôi ngày 3, nhưng tỷ lệ thai diễn tiến cộng dồn là tương đương ở cả 2 nhóm.
RISK OF POST STROKE PNEUMONIA DURING HOSPITALIZATION
Authors: Massie Juliana Gracia G.E.P , Sitorus Ratna , Kariasa I Made , Gultom Yunisar , Khairani Maya , Wulandari Noor 
Published: December 2021

Introduction: Post-stroke pneumonia is the most a common complication during the first few weeks after a stroke. Thus, a score is needed for the early identification of stroke patients with an increased risk of pneumonia to assist the nursing team in preventing the onset of pneumonia in stroke patients during hospitalization. This study aimed to assess the application of the A2DS2 score to predict pneumonia in acute ischemic stroke patients.
Method: This is a diagnostic study that used a cross-sectional method conducted among adult acute ischemic stroke patients. Data analysis was performed to assess the calibration and discrimination performance of the A2DS2 score.
Results: A total of 16 respondents were followed up. The incidence of post-stroke pneumonia was observed in 6 patients (37.5%).
Conclusion: This scoring proved clinically accurate to predict the incidence of pneumonia in acute ischemic stroke patients.
SYNERGISM TEST OF DATE (PHOENIX DACTYLIFERA L.) AND RAW TEMPE ON ANTIOXIDANT ACTIVITY
Authors: Putri Intan Kurnia , Rani Aynna Sufana 
Published: December 2021

Introduction: Dates and tempeh are foods that both contain antioxidant compounds. Antioxidant compounds such as flavonoids and isoflavones are known to be found in dates and tempeh. This study was conducted to see how much antioxidant activity contained in dates and tempeh and how the effect of dates and tempeh consumed simultaneously on the increase in total antioxidant activity.
Method: This study uses a direct experimental design with prospective data collection. The selected samples were dates with the type of sukkari and tempeh wrapped in plastic. Data processing was carried out using a simple linear regression statistical method.
Results: The DPPH test method with UV-Visible Spectrophotometry instrument showed the results of the % inhibition value of dates fruit of 39.99% and tempeh of 24.52%. Testing the synergistic effect using 7 treatments showed that the treatment with a ratio of 50:50 had a higher % inhibition value than the other treatments, which showed that consuming dates and tempeh in a ratio of 50:50 could provide a synergistic effect on antioxidant activity.
Conclusion The results obtained indicate that both samples, both dates and tempeh have high antioxidant activity, consuming both simultaneously can increase antioxidant activity. So it can be concluded that there is an effect on the synergistic effect of antioxidant activity of dates and tempeh which are consumed simultaneously. It is recommended to conduct research on the antioxidant activity of dates and tempeh using other test methods, and further research on the formulation of the preparation or clinical trials using mice.
THE CORRELATION OF MOTHER’S KNOWLEDGE AND ATTITUDE WITH BREASTFEEDING PRACTICES IN TULANG BAWANG BARAT DISTRICT AT 2021
Authors: Yulianty Anik , Irianto Sugeng Eko , Kustiani Ai 
Published: December 2021

Introduction:Breast milk is a liquid formed from a mixture of two substances, namely fat and water contained in a solution of protein, lactose and inorganic salts produced by the mother's breast glands, and is useful as baby food. Mother's knowledge and attitude in exclusive breastfeeding plays an important role in increasing the growth and development of children. The purpose of this study was to determine the relationship between the level of knowledge (cognitive factors) and attitudes (affective factors) of mothers in the practice of exclusive breastfeeding in Tulang Bawang Barat District in 2021.
Method: This research is a quantitative research, with a cross sectional approach. The population in this study were all mothers who had babies > 6 months-12 months as many as 2285 with samples taken as many as 93 respondents. The object of this research is exclusive breastfeeding, knowledge and attitude. The research was conducted in June 2021 in the District of Tulang Bawang Barat. Collecting data using a questionnaire, data analysis is univariate, bivariate and multivariate.
Results: The results showed that there was a relationship between knowledge (p value = 0.016, OR = 3.264), and attitudes (p value = 0.001, OR = 7.848) towards exclusive breastfeeding in Tulang Bawang Barat District in 2021. Dominant factors related to exclusive breastfeeding in Tulang Bawang Barat District in 2021, namely the attitude with a p-value of 0.000 OR 10.197.
Conclusion: The dominant factor related to the practice of exclusive breastfeeding in Tulang Bawang Barat is the attitude of the mother. To improve the attitude of mothers in the Practice of Exclusive Breastfeeding, the Health Office needs to carry out health promotions with a more frequent frequency by using more attractive health promotion media in collaboration with the health promoter team at the puskesmas.
Penerapan Senam Kaki Diabetik Untuk Peningkatan Sensitivitas Kaki Pada Pasien Diabetes Mellitus Tipe 2
Authors: Ismiyati I , Rejeki Herni 
Published: December 2021

AbstractDiabetes mellitus is a disorder characterized by elevated blood sugar levels, due to abnormalities in insulin secretion. This results in nerve cells edema and triggers the stimulation of various enzymes that can damage nerve cell through both metabolic and neurovascular factors. This condition will interfere with the supply of blood and oxsygen to the nerve cells, especially in the peripheral areas of the feet and hands. To prevent this, it is neccesary to do diabetic foot exsercises in people with diabetes mellitus. This scientific paper focused on two famillies with diabetes mellitus. the result stated applying diabetic food exercises for the patient is the efective and it could be done once a day. Furthermore, it also can help improve blood circulation in the legs. Through movements in diabetic food exercises, the muscles will contract so that it will increase the sensitivity of the feet in poeple with diabetes mellitus. Even if it is done routinely, it can prevent the occurrence of non-ulcer wounds or ulcers. Therefore, it is expected for the familly to support the patient in applying the exercises.Keywords: Diabetic Foot Exercises, Foot Sensitivity
Abstrakkadar gula dalam darah yang diakibatkan karena kelainan sekresi insulin akibatnya edema sel saraf serta memicu stimulasi berbagai enzim yang dapat merusak sel saraf baik melalui faktor metabolik maupun faktor neurovaskular, hal terdebut akan mengganggu suplai darah dan oksigen menuju sel saraf terutama di daerah perifer kaki dan tangan. Untuk mencegah akibat tersebut dilakukan senam kaki diabetik pada penderita Diabetes Mellitus. Fokus karya tulis ilmiah adalah 2 keluarga dengan Diabetes Mellitus Hasil penerapan senam kaki diabetik yang di lakukan untuk meningkatkan sensitivitas kaki pada penderita Diabetes Mellitus efektif untuk di terapkan pada penderita Diabetes Melitus bila dilakukan secara rutin satu kali sehari, senam kaki diabetik dapat membantu melancarkan sirkulasi darah pada kaki, melalui gerakan pada senam kaki diabetik otot-otot akan berkontraksi sehingga akan meningkatkan sensitivitas kaki pada penderita Diabetes Mellitus. Bahkan jika dilaukan secara rutin dapat mencegah terjadinya luka non ulkus ataupun luka ulkus. Di harapkan keluarga memberikan dukungan pada keluarga yang sakit dengan mendampingi saat melakukan latihan senam kaki diabetik.Kata kunci: Senam Kaki, Sensitivitas Kaki
Penerepan Kompres Dingin Pada Anak Usia Sekolah (6-12 Tahun) Untuk Mengatasi Nyeri Pemasangan Infus: Literature Review
Authors: Saputri Khofifah Tya , Rofiqoh Siti 
Published: December 2021

AbstractOne of the non-pharmocological therapis to treat infusion pain is cold compress therapy. This study aims to investigate how cold compress therapy can overcome infusion pain. It is a literature review with three articles taken from Google Scholar, with cold compress, school age children, and infusion pain as the key. Those are full text article and published in 2013-2020. It took from 86 respondents, male (65%) and female (35%), with the age from 6 to 12 yers old. The result show to those who were given the therapy has light pain with the avarage value 2,50. Otherwise, those who were not given the one, has a light pain with the avarage value 6,09. Therefore, it can be concluded the cold compress therapy can overcome infusion pain in school age children (6-12) yers old. And, it is expected for health services to apply this therapy.Keywords: school age children, cold compress, infusion pain
AbstrakSalah satu terapi non farmakologi untuk mengatasi nyeri pemasangan infus adalah terapi pemberian kompres dingin. Penelitian ini bertujuan untuk menggambarkan terapi kompres dingin pada anak untuk mengatasi nyeri pemasangan infus. Desain karya tulis ilmiah berupa literatur review dengan jumlah tiga artikel yang diambil dari laman google scholar dengan kata kunci “kompres dingin”, “anak usia sekolah”, dan “nyeri pemasangan infus” berupa artikel fulltex, terbit tahun 2013-2020. Hasil analisa karekteristik responden dari ketiga artikel menunjukkan jumlah responden 86, sebagian besar laki-laki (65%) dan (35%) perempuan, umur 6-12 tahun. Nyeri pada kelompok yang diberikan kompres dingin yaitu nyeri ringan dengan nilai rata-rata (2,50) dan yang tidak diberikan kompres dingin yaitu nyeri sedang dengan nilai rata-rata (6,09). Kesimpulannya adalah terapi kompres dingin dapat mengatasi nyeri saat pemasangan infus pada anak usia sekolah (6-12 tahun). Saran bagi pelayanan kesehatan untuk menerapkan terapi kompres dingin untuk mengatasi nyeri saat pemasangan infus pada anak usia sekolah (6-12 tahun). Kata kunci: Anak usia sekolah; Kompres dingin; Nyeri pemasangan infus