bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduction principle at work
Authors: Pötzsche Christian , Russ Evamaria 
Published: April 2021

Abstract
The purpose of this informal paper is three-fold: First, filling a gap in the literature, we provide a (necessary and sufficient) principle of linearized stability for nonautonomous difference equations in Banach spaces based on the dichotomy spectrum. Second, complementing the above, we survey and exemplify an ambient nonautonomous and infinite-dimensional center manifold reduction, that is Pliss’s reduction principle suitable for critical stability situations. Third, these results are applied to integrodifference equations of Hammerstein- and Urysohn-type both in C- and Lp
-spaces. Specific features of the nonautonomous case are underlined. Yet, for the simpler situation of periodic time-dependence even explicit computations are feasible.
Large birth size, infancy growth pattern, insulin resistance and β-cell function
Authors: Huang Rong , Dong Yu , Nuyt Anne Monique , Levy Emile , Wei Shu-Qin , Julien Pierre , Fraser William D , Luo Zhong-Cheng 
Published: April 2021

Objective
Large birth size programs an elevated risk of type 2 diabetes in adulthood, but data are absent concerning glucose metabolic health impact in infancy. We sought to determine whether the large birth size is associated with insulin resistance and β-cell function in infancy and evaluate the determinants.

Design and participants
In the Canadian 3D birth cohort, we conducted a nested matched (1:2) study of 70 large-for-gestational-age (LGA, birth weight >90th percentile) and 140 optimal-for-gestational-age (OGA, 25th–75th percentiles) control infants. The primary outcomes were homeostasis model assessment of insulin resistance (HOMA-IR) and beta-cell function (HOMA-β) at age 2-years.

Results
HOMA-IR and HOMA-β were similar in LGA and OGA infants. Adjusting for maternal and infant characteristics, decelerated growth in length during early infancy (0–3 months) was associated with a 25.8% decrease (95% confidence intervals 6.7–41.0%) in HOMA-β. During mid-infancy (3–12 months), accelerated growth in weight was associated with a 25.5% (0.35–56.9%) increase in HOMA-IR, in length with a 69.3% increase (31.4–118.0%) in HOMA-IR and a 24.5% (0.52–54.3%) increase in HOMA-β. Decelerated growth in length during late infancy (1–2 years) was associated with a 28.4% (9.5–43.4%) decrease in HOMA-IR and a 21.2% (3.9–35.4%) decrease in HOMA-β. Female sex was associated with higher HOMA-β, Caucasian ethnicity with lower HOMA-IR, and maternal smoking with lower HOMA-β.

Conclusions
This study is the first to demonstrate that large birth size is not associated with insulin resistance and β-cell function in infancy but infancy growth pattern matters. Decelerated infancy growth may be detrimental to beta-cell function.
Apoplexy of microprolactinomas during pregnancy: report of five cases and review of the literature
Authors: Kuhn Emmanuelle , Weinreich Alexandra A , Biermasz Nienke R , Jorgensen Jens Otto L , Chanson Philippe 
Published: April 2021

Context
Prolactinomas frequently cause amenorrhoea, galactorrhoea and infertility and require dopamine agonist (DA) treatment to normalize prolactin levels and hence, restore ovulation. The vast majority of female patients harbour microprolactinomas in whom DA treatment is usually discontinued at the time of pregnancy diagnosis and surveillance is generally limited as the symptomatic growth is considered very rare.

Case descriptions
We report five cases of women harbouring a microprolactinoma in whom symptomatic pituitary apoplexy occurred during pregnancy. Only one necessitated surgery during pregnancy, while the others were treated conservatively by reintroducing DAs in three. A systematic literature review found reports of four additional cases among 20 cases of prolactinomas (both macro- and micro-prolactinomas) complicated by apoplexy during pregnancy.

Conclusion
During pregnancy, pituitary apoplexy may occur in pre-existing microprolactinomas, causing tumour enlargement and headache, which may be self-limiting but may require intervention by re-initation of dopamine agonists or surgery. Our literature review confirms that this clinical event is rare; nevertheless, physicians managing pregnant patients with microprolactinomas must be aware that symptomatic pituitary apoplexy may incidentally occur in all trimesters of pregnancy and require prompt radiological, endocrine and ophthalmological assessment and treatment.
Long-term Quality of Life After Intensive Care Unit Admission (a Single-Center Observational Study)
Authors: Leggieri C. , Dezza L. , Oltolini B. , Lembo R. , Noto B. , Villa S. M. , Belletti A. , Lombardi G. , Battaini A. , Pedrini E. , Zuccato C. F. , Zangrillo A. 
Published: April 2021

Patients may experience long-term physical, psychological and cognitive impairment after intensive care unit (ICU) discharge, a condition commonly described as post-intensive care syndrome. The relative contribution of each of these components to long-term quality of life was never investigated.The aim of this studyis to identify the type and severity of disability and QoL at the discharge from ICU and up to following 6 months.Material and Methods. All patients (n=218) discharged from a university hospital ICU between April 2016 and July 2017 were eligible. Exclusion criteria included: age <18 years, brain or spinal injury, life expectancy <90 days, and ICU stay <12 hours. The Short Form Health Survey (SF-36), and 5-level EuroQoL-5D (EQ-5D-5L) questionnaires were administered at ICU discharge, and at 30-, 90- and 180-days. We compared patients requiring short-term ICU monitoring (IM, Intensive Monitoring,n=109) or patients requiring ICU treatment (IT, Intensive Treatment,n=109).Results. All dimensions of SF-36 and EQ-5D-5L parameters increased from ICU discharge to 180-days, except for the SF-36 Synthetic index linked to mental health (P=0.08). All EQ-5D-5L parameters improved significantly in the IT group, while only Visual Analog Scale Health Perception improved in the IM group.Conclusion. ICU survivors suffer long-term physical and psychological sequelae. The perception of Quality of Life is reduced after ICU discharge. The psychological and cognitive dimensions were more compromised than physical ones. Patients discharged from the ICU may benefit from specific intensive care follow-up clinics addressing their needs in term of psychological and cognitive support.
Causes, occupational risk and socio-economic determinants of eye injuries: a literature review
Authors: Kyriakaki Elli DO , Symvoulakis Emmanouil K , Chlouverakis Gregory , Detorakis Efstathios T 
Published: April 2021

Purpose. This review provides literature views on ocular trauma, with emphasis on common causes of injury, occupational risk, socio-economic factors, management peculiarities and some implications on overall care approach, from prevention to treatment.
Methods. A literature search was performed using key words in PubMed to extract the most relevant articles on ocular injuries, from an occupational point of view. Seventeen relevant articles were included out of seventy-two. Eight relevant articles were found from the references of the articles included and were also added. The total number of articles for this systematic search analysis was twenty-five. Collected information was tabulated in the Appendix.
Results. Most of the included publications were original articles. Many studies were retrospective and cross-sectional with a satisfactory rate of participant recruitment when reported. Most of eye injuries occurred in the workplace. Common eye injuries were due to foreign bodies and corneal abrasions. High-risk occupations included welders, farmers, metalworkers and grinding, construction and manufacturing workers. Most of the injuries could be preventable by using suitable protective eye devices (PED) but appropriate protection is a more complex process than it appears.
Conclusions. Findings of this review showed that it is compulsory to inform people about the risk and consequences of eye injuries. Eye care services should be designed keeping in mind geo-epidemiologic trauma etiology patterns and local health system capacity. Issues of adherence to prevention measures remain object of knowledge dissemination, educational planning and cultural appraisal. Modernizing equipment and respecting workplace regulations are tasks that deserve continuous attention.
Spatial Issues and Covid-19 Dispersion in Small Cities of The Amazon River Delta
Authors: Costa Sandra Maria Fonseca da , Lima Viviana Mendes , Carmos Monique Bruna Silva do , Montoia Gustavo Rodrigo Milaré 
Published: April 2021

The COVID - 19 virus emerged in China and has spread to all areas in Brazil, including the Amazon River Delta, where the population lacks essential services. Thus, this article aims to characterize the dispersion of COVID-19 in the small municipalities of the Amazon River Delta, which have fewer than 50,000 inhabitants, detailing the towns' situation. Covid-19 data provided by the health departments of the states of Amapá and Pará, and census data from the IBGE, were used to create maps of the disease for the Delta's municipalities. The virus circulated rapidly to the smallest localities, where the health service and sanitary conditions are precarious, leading to a severe contamination rate. Together with other known aspects, this is yet another opportunity to show the regional needs and the importance of public policies for this population.
Predicting High Risk Patients for Negative Appendectomy and Severe Appendicitis Using Inflammatory Biomarkers
Authors: ERDOĞAN Alirıza , ÇINAROĞLU Selim 
Published: April 2021

Objective: The aim of the present study is to evaluate the value of inflammatory parameters and indices of complete blood count (CBC) and C-reactive protein (CRP) in predicting negative laparotomies and severity of acute appendicitis in adults.
Material and Methods: A total of 1389 patients who had undergone appendectomy between January 2015 and November 2020 were enrolled in this observational and cross-sectional study. Age, gender, preoperative CRP values, inflammatory parameters of CBC and the pathologic diagnosis were recorded.
Multivariate analysis and logistic regression analysis were performed.
Results: In multivariate model white blood cell (WBC), platelet count (PLT), mean platelet volume (MPV), absolute neutrophil and lymphocyte counts, neutrophil percentage (NEU%), lymphocyte percentage (LYM%), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio and CRP-to-lymphocyte
ratio (CLR) were significant discriminators of negative laparotomy (p
Analysis of acquisition and the monthly cost of antihypertensive therapy with modern fixed-dose combinations in the Far Eastern Federal District
Authors: Soboleva M. S. , Loskutova E. E. 
Published: April 2021

Objective: analyzing the acquisition and monthly costs for patients on modern fixed-dose antihypertensive combinations in three regions of the Far Eastern Federal District.Material and methods. Intra-group analysis of retail of antihypertensive drugs for 2019 in drugstores of the Khabarovsk Region, Sakhalin Region, Amur Region (n=100) was carried out. The calculation of the monthly cost of therapy was performed and total sales indicators were identified. Statistical analysis: dispersion analysis, Spearman's rank correlation coefficient, Kruskal–Wallis test.Results. The maximum demand in patients among combinations of -blockers in the price range of 100-500 rubles: atenolol+chlortalidone; bisoprolol+amlodipine. In the grope of combinations of angiotensin-converting enzyme inhibitors with diuretics/calcium channel blockers, the most often acquired were: perindopril/ramipril+indapamide/amlodipine, enalapril+hydrochlorothiazide – in the price segment of 500–1000 rubles. Preferences for the use of combinations of angiotensin II receptor blockers+diuretic/calcium channel blockers: valsartan+amlodipine with a monthly cost of therapy of 300–500 rubles; losartan+hydrochlorothiazide – 100–500 rubles and azilsartan+chlortalidonee – 500–1000 rubles. The most popular three-component drugs were valsartan+amlodipine+hydrochlorothiazide, perindopril+amlodipine+indapamide with a monthly cost over 500 rubles. Differences in the acquisition structure of fixed-dose antihypertensive combinations between regions were statistically significant.Conclusion. The share of sales of combined antihypertensive drugs remains insignificant. The main selection criteria within an international nonproprietary name are affordability or trust in a brand. The presence of a reliable correlation of the acquisition structure with the region proves the influence of regional preferences of specialists in drug prescribing.
Dendrochronological study of Cedrus deodar Grown at Kumrat valley Dir Upper KPK, Pakistan: Evaluation of Tree Age and Increment Based on Increment Core
Authors: Sajad Sajad , Jawad Jawad , Ul Haq Ikram 
Published: April 2021

The present research was conducted for tree-rings study in a mixed stand of Himalayan Species Credur deodar in Kumrat valley Dir Upper KPK, Pakistan. Tree-rings analysis was related to the counting of tree ring. Random sampling method was used, and 70 sample trees were selected, tree heights and diameters were measured, and increment cores were collected from each sample-tree diameter at the height at breast point to be analyzed and studied in the laboratory. The objectives of the study were to determine the exact age of tree and to evaluate total and mean annual increment in the basal area and tree volume based on the increment cores. Regression models revealed the impacts of tree age on the basal area and tree-volume increment. Results showed the minimum basal-area increment was 0.0028 m2 at the age of 10 years, the maximum basal-area increment was 2.658 m2 at the age of 60 years, with mean was 0.95±0.677 m2 at the age of 36 years and R2 was 0.9593. The maximum tree-volume increment was 1.42 m3 at the age of 60 years, the minimum tree-volume increment was 0.010 m3 at the age of 10 years, with mean was 1.35±0.96 m3 at the age of 36 years and R2 was 0.9167. The minimum mean annual-basal area increment was 0.0027 m2, the maximum mean annual-basal area increment was 0.048 m2, and the average increment was 0.022±0.010 m2. The maximum mean-annual increment in tree volume was 0.068 m3 at the age of 60 years, the minimum mean-annual increment was 0.0039 m3 at the age of 10 years, with mean was 0.032±0.014 m3 at the age of 36 years and R2 was 0.8903. Results showed a strong positive relationship of tree age with area and volume increment.
Keywords: Basal area, increment, tree age, volume
“WINS” untuk Pengelolaan Kawasan Lindung Berdasarkan Sistem Agroforestri Aren (Arenga pinnata) di Zona Rehabilitasi Taman Nasional Meru Betiri
Authors: Rahmatan Rahmatan , Zahro Yulia Raudhatul Balaqis , Azizah Safira 
Published: April 2021

WINS" (Win-Win Strategy) in the management of protected areas is the strategy that benefit both parties. Agroforestry with forest trees accompanied by agricultural crops may benefits the community if it is implemented in line with the management of Meru Betiri National Park (TNMB) policies. The agroforestry plants proposed in this study were aren (Arenga pinnata), java chili (Piper retrofractum), and porang (Amorphophallus muelleri). This study recommends four strategies for better agroforestry practice in TNMB, i.e.,g. 1) strategy I, increasing public awareness of the urgency of the preservation of national park areas; 2) strategy II, formulating policies to support agroforestry as a strategic management effort; 3) strategy III, education and counseling, as a strengthening of the role of extension workers; and 4) strategy IV, facilitating access to relevant data across all participating institutions and is supported in a multidisciplinary manner. This model may be used as a reference for agroforestry models in conservation areas, especially in TNMB, which will optimize the development of native plants in an area.
Keywords: agroforestry, Arenga pinnata, Meru Betiri National Park, SWOT analysis, win-win strategy
Hasil Padi dan Kelimpahan Gulma dengan Aplikasi Jenis Pupuk Berbeda di Lahan Kering Tadah Hujan pada Musim Kemarau
Authors: Ahadiyat Yugi Rahayu , Sisno Sisno 
Published: April 2021

Rice yield and proper weed control need to be increased through an environmentally friendly agricultural system approach in rainfed land during the dry season by reducing the dosage of synthetic fertilizers. This study aims to determine the effect of different fertilizer applications on rice yield and weed abundance in rainfed land during the dry season. The study used a split-plot design, with the main plot of rice variety, i.e., Situ Bagendit and IR-64, and subplots of fertilizer, namely synthetic fertilizers (N, P, K), organic fertilizers + P60 + ½ dose of synthetic fertilizers, organic fertilizers + PGPR + ½ dose of synthetic fertilizer and organic fertilizer + P60 + PGPR + ½ dose of synthetic fertilizer with three replications. The variables observed were rice yield components, namely panicle length, total empty grain and content per panicle, grain weights per hill, effective plot and hectare, 1000 grain weight, harvest index, and weeds summed dominance ratio (SDR). The synthetic fertilizers and three various organic fertilizers, biological fertilizers, and synthetic fertilizers gave different results on the SDR of weeds. The weeds of Sphenoclea zeynalica and Cyperus difformis showed consistent dominance with higher SDR than other weeds, i.e.,> 15 and > 10, respectively. The application of organic and biological fertilizers with half the recommended dosage of the synthetic fertilizers is equivalent to applying the recommended dosage of synthetic fertilizers on rice yield during the dry season on the rainfed dryland with low rainfall intensity and a low yield of 1.3–1.7 t/ha.
Keywords: biological fertilizer, inorganic fertilizer, organic fertilizers, rice, weeds
Seleksi Generasi F2 untuk Mendapatkan Jagung dengan Kandungan Antosianin
Authors: Adrianto Hari Isnaini , Mustikarini Eries Dyah , Prayoga Gigih Ibnu 
Published: April 2021

Purple corn is one type of corn plant with high anthocyanin content, which is good for health. Hybridization activities can obtain purple corn with anthocyanin content and yield power of 9.85 tons/ha with selection. This study aims to select F2 generation corn strains that have a purple color. The genetic materials were planted without replicated design. The lines used are derived from the F2 seed results of a cross between purple corn of Marassempulu and white corn of Magetan. There were 120 plant samples. The results showed about 24 lines that had purple seeds in the F2 generation. The selection results with a selection intensity of 50% obtained 12 lines of corn which could be continued for the next generation, namely F2-PxU11-14, F2-PxU11-20, F2-PxU11-21, F2-PxU6-15, F2-PxU11-2, F2-PxU6-16, F2-PxU11-13, F2-PxU11-11, F2-PxU6-5, F2-PxU6-8, F2-PxU11-6, and F2-PxU11-16.
Kata kunci: corn, free-based, hybridization, purple, selection
Analysis of the Impact of RCEP on China’s Mining Market
Authors: Lu Zhiwei 
Published: April 2021

<p>RCEP (Regional Comprehensive Economic Partnership), a modern, comprehensive, high-level and mutually beneficial agreement was signed<span style="font-family: 'Times New Roman';">, which</span> marks the official establishment of the free trade zone with the largest participating population, the most diverse membership structure and the greatest development potential in the world. Benefit<span style="font-family: 'Times New Roman';">ed</span> from RCEP<span style="font-family: 'Times New Roman';">, the</span> regional trade liberalization <span style="font-family: 'Times New Roman';">can be achieved and the</span> rising global inflation expectations <span style="font-family: 'Times New Roman';">can be reached</span>. The mining industry, especially the metal industry, may usher in a new period of development opportunities. However, potential risks still need to be paid attention to. For example, the implementation of RCEP is <span style="font-family: 'Times New Roman';">far less than expectations; </span>the situation of Sino-US trade has further deteriorated<span style="font-family: 'Times New Roman';">;</span> and the implementation of economic stimulus policies in Europe and the United States falls <span style="font-family: 'Times New Roman';">out</span> of expectations.</p>
The Construction of the Protection Mechanism of Rural Landscape in the Process of Urbanization
Authors: Xia Siyi 
Published: April 2021

<p>With the accelerated development of urbanization, China’s rural landscape is declining. To create a “beautiful countryside”, the first thing is to protect the existing rural landscape. There are three aspects that need to be <span style="font-family: 'Times New Roman';">considered </span>to structure the protection mechanism of rural landscape. Cultivated land is an essential part of the rural landscape. It is the basis of protecting the existing cultivated land in the countryside to establish and implement the cultivated land protection system. Rural cultural landscape is the cultural embodiment of the integration of rural society and natural environment. It should follow the principles of integrity, living and authenticity to protect the macro ecological environment and micro internal elements of the cultural landscape. Ecological conditions are closely related to the livability of the human settlement environment and cultural attribute of rural landscape. The construction of ecological civilization requires the government to take the lead and the masses to support, and then balance the benefits between ecologic and economic in the urbanization development.</p>
УТИЛИЗАЦИЯ ОТРАБОТАННОЙ ГЕРМЕТИЗИРУЮЩЕЙ ЖИДКОСТИ В СОСТАВЕ АСФАЛЬТОБЕТОННЫХ ПОКРЫТИЙ
Authors: Дюрягина Антонина Николаевна , Бызова Юлия Сергеевна , Островной Кирилл Александрович , Тюканько Виталий Юрьевич 
Published: April 2021

Актуальность настоящего исследования продиктована необходимостью решений в области вторичной переработки различных промышленных отходов с целью их использования в составе нового продукта. Объект исследования – отработанный герметик АГ-4И, который применяется большими объемами на объектах энергетики, нефтегазодобывающих предприятиях, машиностроительных заводах, городских коммунальных хозяйствах и других отраслях промышленности в системах теплофикации. Вторичная переработка экономит природные ресурсы, сокращает количество твердых отходов, уменьшает загрязнение воздуха и воды и вредные выбросы в атмосферу. Дорожно-строительная отрасль может использовать переработанные материалы в составе асфальтобетонных покрытий. Модифицирование асфальтобетонных смесей отходами производства выступает в качестве приоритетного направления с целью сокращения огромного объема отходов, образующихся из различных источников. Целью настоящей работы явилось исследование возможности утилизации отработанной герметизирующей жидкости АГ-4И в составе асфальтобетонных композиций с целью модифицирования. Методы: реологические методы, структурно-механические методы оценки качества пленок и покрытий. Результаты. Были определены физико-химические и реологические характеристики отработанной герметизирующей жидкости в составе битумных композиций. В результате проведенных исследований выявлено, что консервация исследуемой герметизирующей жидкости в предпочтительном твердом виде является невозможной, т. к. попытки полимеризации полиизобутилена в составе отхода герметизирующей жидкости не привели к изменениям состава. Определено, что введение исследуемой герметизирующей жидкости в состав асфальтобетонных композиций позволяет использовать ее в качестве стабилизирующей и гидрофобизирующей добавки. Как следствие, улучшаются показатели адгезии к минеральным наполнителям и прочность покрытий.