bluuebunny/crossref_metadata_2025_split huggingface dataset:
Middle Jurassic to Early Cretaceous tectonic evolution of the western Klamath Mountains and outboard Franciscan assemblages, northern California–southern Oregon, USA
Authors: Chapman* Alan D. , Yule Doug , Schmidt William , LaMaskin Todd 
Published: December 2021

ABSTRACT
The Klamath Mountains province and adjacent Franciscan subduction complex (northern California–southern Oregon) together contain a world-class archive of subduction-related growth and stabilization of continental lithosphere. These key elements of the North American Cordillera expanded significantly from Middle Jurassic to Early Cretaceous time, apparently by a combination of tectonic accretion and continental arc– plus rift-related magmatic additions. The purpose of this field trip is twofold: to showcase the rock record of continental growth in this region and to discuss unresolved regional geologic problems. The latter include: (1) the extent to which Mesozoic orogenesis (e.g., Siskiyou and Nevadan events plus the onset of Franciscan accretion) was driven by collision of continental or oceanic fragments versus changes in plate motion, (2) whether growth involved “accordion tectonics” whereby marginal basins (and associated fringing arcs) repeatedly opened and closed or was driven by the accretion of significant volumes of material exotic to North America, and (3) the origin of the Condrey Mountain schist, a composite low-grade unit occupying an enigmatic structural window in the central Klamaths—at odds with the east-dipping thrust sheet regional structural “rule.” Respectively, we assert that (1) if collision drove orogenesis, the requisite exotic materials are missing (we cannot rule out the possibility that such materials were removed via subduction and/or strike slip faulting); (2) opening and closure of the Josephine ophiolite-floored and Galice Formation–filled basin demonstrably occurred adjacent to North America; and (3) the inner Condrey Mountain schist domain is equivalent to the oldest clastic Franciscan subunit (the South Fork Mountain schist) and therefore represents trench assemblages underplated &gt;100 km inboard of the subduction margin, presumably during a previously unrecognized phase of shallow-angle subduction. In aggregate, these relations suggest that the Klamath Mountains and adjacent Franciscan complex represent telescoped arc and forearc upper plate domains of a dynamic Mesozoic subduction zone, wherein the downgoing oceanic plate took a variety of trajectories into the mantle. We speculate that the downgoing plate contained alternating tracts of smooth and dense versus rough and buoyant lithosphere—the former gliding into the mantle (facilitating slab rollback and upper plate extension) and the latter enhancing basal traction (driving upper plate compression and slab-shallowing). Modern snapshots of similarly complex convergent settings are abundant in the western Pacific Ocean, with subduction of the Australian plate beneath New Guinea and adjacent island groups providing perhaps the best analog.
Ultrahigh-temperature granulite-facies metamorphism and exhumation of deep crust in a migmatite dome during late- to post-orogenic collapse and extension in the central Adirondack Highlands (New York, USA)
Authors: Metzger Ellen P. , Leech Mary L. , Davis Michael W. , Reeder Jackson V. , Swanson Brandon A. , Waring Heather V. 
Published: December 2021

AbstractThis study combines field observations, mineral and whole-rock geochemistry, phase equilibrium modeling, and U-Pb sensitive high-resolution ion microprobe (SHRIMP) zircon geochronology to investigate sillimanite-bearing felsic migmatites exposed on Ledge Mountain in the central Adirondack Highlands (New York, USA), part of an extensive belt of mid-crustal rocks comprising the hinterland of the Mesoproterozoic Grenville orogen. Phase equilibrium modeling suggests minimum peak metamorphic conditions of 960–1025 °C and 11–12.5 kbar during the Ottawan orogeny—significantly higher pressure-temperature conditions than previously determined—followed by a period of near-isothermal decompression, then isobaric cooling. Petrography reveals abundant melt-related microstructures, and pseudosection models show the presence of at least ~15%–30% melt during buoyancy-driven exhumation and decompression. New zircon data document late Ottawan (re)crystallization at ca. 1047 ± 5 to 1035 ± 2 Ma following ultrahigh-temperature (UHT) metamorphism and anatexis on the retrograde cooling path. Inherited zircon cores give a mean date of 1136 ± 5 Ma, which suggests derivation of these felsic granulites by partial melting of older igneous rocks. The ferroan, anhydrous character of the granulites is similar to that of the ca. 1050 Ma Lyon Mountain Granite and consistent with origin in a late- to post-Ottawan extensional environment. We present a model for development of a late Ottawan migmatitic gneiss dome in the central Adirondacks that exhumed deep crustal rocks including the Snowy Mountain and Oregon anorthosite massifs with UHT Ledge Mountain migmatites. Recognition of deep crustal meta-plutonic rocks recording UHT metamorphism in a migmatite gneiss dome has significant implications for crustal behavior in this formerly thickened orogen.
Mapping global trends in vaccine sales before and during the first wave of the COVID-19 pandemic: a cross-sectional time-series analysis
Authors: Zeitouny Seraphine , Suda Katie J , Mitsantisuk Kannop , Law Michael R , Tadrous Mina 
Published: December 2021

BackgroundWhile the COVID-19 pandemic may have substantially hindered the provision of routine immunisation services worldwide, we have little data on the impact of the pandemic on vaccine supply chains.MethodsWe used time-series analysis to examine global trends in vaccine sales for a total of 34 vaccines and combination vaccines using data from the IQVIA MIDAS Database between August 2014 and August 2020 across 84 countries. We grouped countries into three income-level categories, and we modelled the changes in vaccine sales from April to August 2020 versus April to August 2019 using autoregressive integrated moving average models.ResultsIn March 2020, global sales of vaccines dropped from 1211.1 per 100 000 to 806.2 per 100 000 population in April 2020, an overall decrease of 33.4%; however, the vaccine sales interruptions recovered disproportionately across economies. Between April 2020 and August 2020, we found a significant decrease of 20.6% (p<0.001) in vaccine sales across high-income countries (HICs), in contrast with a significant increase of 10.7% (p<0.001) across lower middle-income countries (LMICs), relative to the same period in 2019. From August 2014 through August 2020, monthly per capita vaccine sales across HICs remained, on average, at least four times higher than in LMICs and nearly three times higher than in upper middle-income countries.ConclusionOur study revealed the heterogeneous impact of COVID-19 on vaccine sales across economies while underlining the substantial consistent disparities in per capita vaccine sales before and during the first wave of the COVID-19 pandemic. Action to ensure equitable distribution of vaccines is needed.
Stress, development and mental health study, the follow-up study of Finnish TAM cohort from adolescence to midlife: cohort profile
Authors: Berg Noora , Kiviruusu Olli , Grundström Jenna , Huurre Taina , Marttunen Mauri 
Published: December 2021

PurposeThis cohort profile describes the Stress, development and mental health study (TAM), which is a cohort study investigating risk and protective factors as well as longitudinal associations regarding mental health and well-being from adolescence to midlife. This interdisciplinary cohort study operates, for example, in the fields of public health, social medicine, psychiatry and the life course perspective.ParticipantsIn 1981 (n=2242, 98.0% of the target population), 1982 (n=2191, 95.6%) and 1983 (n=2194, 96.7%) during school classes, surveys were conducted to all Finnish-speaking pupils (mostly born 1967) in the Tampere region in Finland. Participants of the school study at age 16 in 1983 (n=2194) comprised the base population for the longitudinal data and were followed-up using postal questionnaires in the years 1989, 1999, 2009 and 2019 at ages 22 (n=1656, 75.5% of the age 16 participants), 32 (n=1471, 67.0%), 42 (n=1334, 60.8%) and 52 (n=1160, 52.9%).Findings to dateThe self-reported questionnaires include information on physical and mental health (eg, depression and mood disorders, anxiety disorders), health behaviour and substance misuse (eg, alcohol, tobacco and exercise), socioeconomic conditions, psychosocial resources (eg, self-esteem), social relationships and support, life events, etc. The numerous studies published to date have examined mental health and various factors from several perspectives such as risk and protective factors, individual developmental paths (eg, trajectories) and pathway models (mediation and moderation).Future plansCurrent and future research areas include, for example, longitudinal associations between mental health (eg, depressive symptoms, self-esteem) and (1) substance use (alcohol and tobacco), (2) family transitions (eg, parenthood, relationship status) and (3) retirement. Next follow-up is planned to be conducted at the latest at age 62 in 2029. Before that it is possible to link the data with cause-of-death register.
Understanding attitudes and norms related to sexual and gender-based violence among youth in Jordan: an egocentric social network study protocol
Authors: Gausman Jewel , Abu Sabbah Eman , Othman Areej , Hamad Iqbal Lutfi , Dabobe Maysoon , Langer Ana 
Published: December 2021

IntroductionSexual and gender-based violence (SGBV) is a major public health concern in Jordan, especially among youth. Social acceptance of SGBV is alarmingly high, including among youth. Refugee populations may be at particular risk given limited social support and access to health services combined with increased social and economic pressure and vulnerability. Further research is needed to understand how norms are embodied and reproduced at individual, interpersonal and community levels through relationships between partners, families, peers and community leaders. This study seeks to provide data on attitudes and norms in communities and across youth social networks in order to support gender transformative approaches that seek to change harmful social norms that perpetuate acceptance of SGBV.Methods and analysisThis study will collect egocentric data from 960 youth in Jordan (480 men and 480 women) aged between 18 years and 24 years. Individuals will be asked about their perceptions of norms relating to SGBV in their community as well as their perceptions of the attitudes held by up to 15 individuals within their social network. Data will also be collected on the social, economic and demographic variables, refugee status, experience of depression and anxiety, and social support. We will use multilevel analysis to examine individual and group-level associations. We will also assess other network attributes, such as homophily, the role of social engagement, social learning and social support in the transmission of norms and attitudes.Ethics and disseminationEthical approval was obtained from the Institutional Review Boards of the Harvard T.H. Chan School of Public Health and the University of Jordan. Rigorous ethical protections will be followed with regard to confidentiality and respondent safety. We intend to publish peer-reviewed papers of our findings in addition to a variety of tools and resources targeting diverse audiences, including policy and technical briefs.
Efficacy and safety of bevacizumab in the treatment of adult gliomas: a systematic review and meta-analysis
Authors: Wang Huan , Guo Jianxin , Wang Tianze , Wang Kai , Wu Zhuojun , Sun Tianze 
Published: December 2021

ObjectiveTo assess the efficacy and safety of bevacizumab (BEV) in patients with glioma.DesignSystematic review and meta-analysis.ParticipantsAdults aged 18 years and above, whose histology was confirmed to be malignant glioma.Primary and secondary outcome measuresThe main indicators included progression-free survival (PFS) rate and overall survival (OS) rate, and the secondary indicators were adverse reactions.ResultsA total of 11 clinical centre trials were included in this study for meta-analysis, including 2392 patients. The results of the meta-analysis showed that the median PFS rate of the BEV group was significantly higher than that of the non-BEV group (p<0.00001). When comparing PFS between two groups, we found that the PFS in the BEV group was higher than that in the non-BEV group at 6 months (OR 3.31, 95% CI 2.74 to 4.00, p<0.00001), 12 months (OR 2.05, 95% CI 1.70 to 2.49, p<0.00001) and 18 months (OR 1.31, 95% CI 1.02 to 1.69, p=0.03). But at 24 months (OR 0.83, 95% CI 0.50 to 1.37, p=0.47), there was no significant difference between the two groups. At 30 months (OR 0.62, 95% CI 0.39 to 0.97, p=0.04), the PFS of the BEV group was lower than that of the non-BEV group. Moreover, The results showed that BEV had no significant effect on improving OS, but the adverse reaction in BEV group was significantly higher than that in non-BEV group.ConclusionThe evidence suggests that BEV can significantly prolong the PFS of patients with glioma within 18 months and shorten the PFS of patients after 30 months. This limitation may be related to the subgroup of patients, the change of recurrence mode, the optimal dose of drug, the increase of hypoxia, the enhancement of invasiveness and so on. Therefore, it is necessary to carry out more samples and higher quality large-scale research in the future.
Prognostic accuracy of antenatal Doppler ultrasound for adverse perinatal outcomes in low-income and middle-income countries: a systematic review
Authors: Ali Sam , Heuving Simelina , Kawooya Michael G , Byamugisha Josaphat , Grobbee Diederick E , Papageorghiou Aris T , Klipstein-Grobusch Kerstin , Rijken Marcus J 
Published: December 2021

ObjectivesThis systematic review examined available literature on the prognostic accuracy of Doppler ultrasound for adverse perinatal outcomes in low/middle-income countries (LMIC).DesignWe searched PubMed, Embase, Cochrane Library and Scopus from inception to April 2020.SettingObservational or interventional studies from LMICs.ParticipantsSingleton pregnancies of any risk profile.InterventionsUmbilical artery (UA), middle cerebral artery (MCA), cerebroplacental ratio (CPR), uterine artery (UtA), fetal descending aorta (FDA), ductus venosus, umbilical vein and inferior vena cava.Primary and secondary outcome measuresPerinatal death, stillbirth, neonatal death, expedited delivery for fetal distress, meconium-stained amniotic fluid, low birth weight, fetal growth restriction, admission to neonatal intensive care unit, neonatal acidosis, Apgar scores, preterm birth, fetal anaemia, respiratory distress syndrome, length of hospital stay, birth asphyxia and composite adverse perinatal outcomes (CAPO).ResultsWe identified 2825 records, and 30 (including 4977 women) from Africa (40.0%, n=12), Asia (56.7%, n=17) and South America (3.3%, n=01) were included. Many individual studies reported associations and promising predictive values of UA Doppler for various adverse perinatal outcomes mostly in high-risk pregnancies, and moderate to high predictive values of MCA, CPR and UtA Dopplers for CAPO. A few studies suggested that the MCA and FDA may be potent predictors of fetal anaemia. No randomised clinical trial (RCT) was found. Most studies were of suboptimal quality, poorly powered and characterised by wide variations in outcome classifications, the timing for the Doppler tests and study populations.ConclusionLocal evidence to guide how antenatal Doppler ultrasound should be used in LMIC is lacking. Well-designed studies, preferably RCTs, are required. Standardisation of practice and classification of perinatal outcomes across countries, following the international standards, is imperative.PROSPERO registration numberCRD42019128546
Validating machine learning models for the prediction of labour induction intervention using routine data: a registry-based retrospective cohort study at a tertiary hospital in northern Tanzania
Authors: Tarimo Clifford Silver , Bhuyan Soumitra S , Li Quanman , Mahande Michael Johnson J , Wu Jian , Fu Xiaoli 
Published: December 2021

ObjectivesWe aimed at identifying the important variables for labour induction intervention and assessing the predictive performance of machine learning algorithms.SettingWe analysed the birth registry data from a referral hospital in northern Tanzania. Since July 2000, every birth at this facility has been recorded in a specific database.Participants21 578 deliveries between 2000 and 2015 were included. Deliveries that lacked information regarding the labour induction status were excluded.Primary outcomeDeliveries involving labour induction intervention.ResultsParity, maternal age, body mass index, gestational age and birth weight were all found to be important predictors of labour induction. Boosting method demonstrated the best discriminative performance (area under curve, AUC=0.75: 95% CI (0.73 to 0.76)) while logistic regression presented the least (AUC=0.71: 95% CI (0.70 to 0.73)). Random forest and boosting algorithms showed the highest net-benefits as per the decision curve analysis.ConclusionAll of the machine learning algorithms performed well in predicting the likelihood of labour induction intervention. Further optimisation of these classifiers through hyperparameter tuning may result in an improved performance. Extensive research into the performance of other classifier algorithms is warranted.
Scoping review to identify and map non-pharmacological, non-surgical treatments for dysphagia following moderate-to-severe acquired brain injury
Authors: Eskildsen Signe Janum , Poulsen Ingrid , Jakobsen Daniela , Riberholt Christian Gunge , Curtis Derek John 
Published: December 2021

IntroductionDysphagia is a common and critical consequence of acquired brain injury (ABI) and can cause severe complications. Dysphagia rehabilitation is transforming from mainly compensatory strategies to the retraining of swallowing function using principles from neuroscience. However, there are no studies that map interventions available to retrain swallowing function in patients with moderate-to-severe ABI.ObjectiveTo systematically map the accessible research literature to answer the research question:Which non-surgical, non-pharmacological interventions are used in the treatment of dysphagia in patients with moderate and severe ABI in the acute and subacute phase?DesignScoping review based on the methodology of Arksey and O’Malley and methodological advancement by Levacet al.Data sourcesMEDLINE, Embase, Cochrane Library, CINAHL, PsycINFO, Web of Science, OTseeker, speechBITE and PEDro were searched up until 14 March 2021.Eligibility criteriaAll studies reporting rehabilitative interventions within 6 months of injury for patients with moderate-to-severe ABI and dysphagia were included.Data extraction and synthesisData was extracted by two independent reviewers and studies were categorised based on treatment modality.ResultsA total of 21 396 records were retrieved, and a final of 26 studies were included. Interventions were categorised intocorticalornon-corticalstimulation of the swallowing network. Cortical stimulation interventions were repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation. Non-cortical were complex swallowing interventions, neuromuscular electrical stimulation, pharyngeal electrical stimulation (PES), sensory stimulation, strengthening exercises and respiratory muscle training.ConclusionThis scoping review provides an overview of rehabilitative dysphagia interventions for patients with moderate and severe ABI, predominantly due to stroke, in the acute and subacute phase. Positive tendencies towards beneficial effects were found for rTMS, complex swallowing interventions, PES and cervical strengthening. Future studies could benefit from clear reporting of patient diagnosis and disease severity, the use of more standardised treatment protocols or algorithms and fewer but standardised outcome measures to enable comparison of effects across studies and interventions.
Loneliness and its predictors among older adults prior to and during the COVID-19 pandemic: cross-sectional and longitudinal survey findings from participants of the Atherosclerosis Risk in Communities (ARIC) Study cohort in the USA
Authors: Kucharska-Newton Anna , Matsushita Kunihiro , Mok Yejin , Minotti Melissa , Oelsner Elizabeth C , Ring Kim , Wagenknecht Lynne , Hughes Timothy M , Mosley Thomas , Palta Priya , Lutsey Pamela L , Coresh Joe 
Published: December 2021

ObjectivesWe aimed to ascertain the prevalence of perceived loneliness among older adults following the onset of the COVID-19 pandemic and to examine factors contributing to the perception of loneliness.DesignCross-sectional and longitudinal data from the Atherosclerosis Risk in Communities (ARIC) Study cohort.SettingThe ARIC Study cohort, a prospective cohort that recruited (1987–1989) participants from four distinct communities in the USA.Participants2984 ARIC cohort members.Primary and secondary outcomesPerceived loneliness assessed using the University of California at Los Angeles (UCLA) UCLA three-item Loneliness Scale telephone interviews conducted May–October 2020 and prior to March 2020.ResultsOf the total 5037 participants alive in 2020, 2984 (56.2%) responded to the UCLA three-item questionnaire (mean age 82.6 (SD 4.6) years, 586 (19.6%) black participants, 1081 (36.2%) men), of which 66 (2.2%) reported having had a COVID-19 infection during the observation period. The proportion of participants reporting feeling lonely was 56.3% (n=1680). Among participants with repeat measures of loneliness (n=516), 35.2% (n=182) reported feeling more lonely following pandemic onset. Self-rated health and emotional resilience were strongly associated with self-perceived loneliness. The burden of COVID-19 infections, concern about the pandemic and decreased self-reported physical activity were greater among black as compared with white participants and among those with an educational attainment of less than high school as compared with high school or more.ConclusionFindings from this study document the increase in perceived loneliness among older adults during the COVID-19 pandemic in the USA.