bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Effects of Innovation Ecosystem Models on Innovative Performances of Start-Ups: The Contingent Role of Open Innovation
Authors: Zhang Jing , Yu Bo , Lu Chang 
Published: July 2021

Abstract
A firm’s participation in an innovation ecosystem can increase its competitiveness and potentiality in turbulent circumstances. From a resource-based view (RBV) and the value proposition perspective, this study explored how participation in heterogeneous innovation ecosystems affects the innovative performances (IPs) of start-ups. We studied the adaptability between innovation ecosystem models and open innovation (OI) strategies, as well as examined their effects on new ventures. Specifically, innovation ecosystem models were classified into platform- and product-based innovation ecosystems according to the structural logic of accessing resources. Then, we examined the effects of these ecosystems on the IPs of start-ups and analyzed the moderating effects of the breadth and depth of OI on these ecosystems. The findings revealed that the participation of start-ups in such ecosystems had positive effects on their IPs and OI breadth’s inverted U-shape moderated the relationships between product-based innovation ecosystems and the IPs while strengthening the positive relationships between platform-based innovation ecosystems and the IPs. In addition, OI depth enhanced the positive effects of both ecosystems on the IPs of start-ups. This study has enlightening implications for research on innovation ecosystems, OI, and entrepreneurs.
Efficacy of Ḥammām-i-yābis (dry bath) in metabolic syndrome: a single arm, open-labelled clinical trial
Authors: Ahmad Mohammad Zaki , Ansari Abdul Nasir , Nayab Mohd 
Published: July 2021

Abstract

Objectives
This study intended to evaluate the efficacy of Ḥammām-i-yabis (dry bath) in metabolic syndrome as primary objective and perceived improvement and changes in quality of life as secondary objective.

Methods
The study was designed as single arm, open-labelled, pre and post without control clinical trial comprising 30 diagnosed cases of metabolic syndrome belonging to 20–50 years of age of either sex. The enrolled patients were exposed to the dry heat of Ḥammām-i-yābis for 15 min at a temperature of 60 degree centigrade on every third day for a duration of 30 days (a total of 10 sittings). Objective parameters comprising systolic and diastolic blood pressure and waist circumference were assessed on every follow up, while other objective parameters (FBS, HDL and Serum Triglycerides) were assessed before and after the study.

Results
Significant statistical difference was observed in objective parameters. Two tailed paired Student’s t-test, (for pre and post) and repeated measure ANOVA (for 0, 15th and 30th day) were used to find the significance of mean change in study parameters. No significant adverse change appeared in safety parameters.

Conclusions

Ḥammām-i-yābis was found effective, safer, more feasible and less expensive regimenal modality for the patients of metabolic syndrome.
Association of antimullerian hormone with the size of the appendix testis, the androgen and estrogen receptors and their expression in the appendix testis, in congenital cryptorchidism
Authors: Sinopidis Xenophon , Kostopoulou Eirini , Rojas-Gil Andrea Paola , Panagidis Antonios , Kourea Eleni , Skiadopoulos Spyros , Georgiou George , Spiliotis Bessie E. 
Published: July 2021

Abstract

Objectives
Antimullerian hormone (AMH) causes regression of the mullerian ducts in the male fetus. The appendix testis (AT) is a vestigial remnant of mullerian duct origin, containing both androgen (AR) and estrogen (ER) receptors. The role of both AMH and AT in testicular descent is yet to be studied. We investigated the possible association of AMH with AT size, the AR and ER, and their expression in the AT, in congenital cryptorchidism.

Methods
A total of 26 patients with congenital unilateral cryptorchidism and 26 controls with orthotopic testes were investigated, and 21 ATs were identified in each group. AMH and insulin-like three hormone (INSL3) concentrations were measured with spectrophotometry. AR and ER receptor expression was assessed with immunohistochemistry using monoclonal antibodies R441 for AR and MAB463 for ER. For the estimation of receptor expression, the Allred Score method was used.

Results
AMH concentrations did not present significant differences between patients with congenital cryptorchidism and the controls. Also, no correlation was found between AMH, INSL3, and AT length. Allred scores did not present significant differences. However, expression percentiles and intensity for both receptors presented significant differences. Three children with cryptorchidism and the highest AMH levels also had the highest estrogen receptor scores in the AT.

Conclusions
No association was found between AMH and the studied major parameters. However, higher AMH concentrations, in combination with higher estrogen receptor scores in the AT, may play a role in cryptorchidism in some children. Larger population samples are needed to verify this observation.
New obstetric systemic inflammatory response syndrome criteria for early identification of high-risk of sepsis in obstetric patients
Authors: Rojas-Suarez Jose , Paternina-Caicedo Angel , Miranda Jezid , Cuello María , Piñerez María , Santacruz José , Anichiarico Walter , Bello-Muñoz Camilo , Gonzalez-Hernandez Jeniffer , Tymon Jennifer , Coronado Jorge , Tolosa Jorge , Meza Camila , Iriarte Nicole , Ramos Alfonso , Soto Oscar , Maza Fabian , Viloria Mariam , Dueñas-Castell Carmelo 
Published: July 2021

Abstract

Objectives
We aimed to establish new cut-off values for SIRS (Systemic Inflammatory Response Syndrome) variables in the obstetric population.

Methods
A prospective cohort study in pregnant and postpartum women admitted with systemic infections between December 2017 and January 2019. Patients were divided into three cohorts: Group A, patients with infection but without severe maternal outcomes (SMO); Group B, patients with infection and SMO or admission to the intensive care unit (ICU); and Group C, a control group. Outcome measures were ICU admission and SMO. The relationship between SIRS criteria and SMO was expressed as the area under the receiver operating characteristics curve (AUROC), selecting the best cut-off for each SIRS criterion.

Results
A total of 541 obstetric patients were enrolled, including 341 with infections and 200 enrolled as the reference group (Group C). The patients with infections included 313 (91.7%) in Group A and 28 (8.2%) in Group B. There were significant differences for all SIRS variables in Group B, compared with Groups A and C, but there were no significant differences between Groups A and C. The best cut-off values were the following: temperature 38.2 °C, OR 4.1 (1.8–9.0); heart rate 120 bpm, OR 2.9 (1.2–7.4); respiratory rate 22 bpm, OR 4.1 (1.6–10.1); and leukocyte count 16,100 per mcl, OR 3.5 (1.6–7.6).

Conclusions
The cut-off values for SIRS variables did not differ between healthy and infected obstetric patients. However, a higher cut-off may help predict the population with a higher risk of severe maternal outcomes.
Radiometric analysis of micas used in many industries and evaluation of radiological hazards
Authors: Gezer Ferhat , Turhan Şeref , Ufuktepe Yüksel 
Published: July 2021

Abstract
Mica group minerals have been utilized in various industries such as paint, cement, rubber, plastic, paper, automotive, cosmetics, textile, etc. due to their unique electrical, thermal, and mechanical properties. In this study, the radiometric properties of 58 mica samples collected from three quarries operated commercially in Turkey were investigated using gamma-ray spectroscopy with an HPGe detector. The average activity concentrations of 226Ra, 232Th, and 40K analyzed in mica samples were found as 12, 44, and 2763 Bq kg−1, respectively. The radon emanation coefficient and radon mass exhalation rate of mica samples varied from 4 to 22% with an average of 10% and 0.4–5.9 µBq kg−1 s−1 with an average of 2.6 µBq kg−1 s−1, respectively. The radiological hazard caused by the utilization of mica samples as raw materials in the cement and concrete industry was evaluated for adults by calculating the gamma index and annual effective dose due to external exposure indoor. The study results revealed that there are no significant radiological hazards associated with the utilization of mica samples as building raw materials.
Historia de 20 años de trabajo visionario en la publicación científica
Authors: Vega Villalobos Nora Agnes 
Published: July 2021

La Revista Enfermería Actual en Costa Rica inició hace veinte años como un proyecto de docencia para crear una revista electrónica. El objetivo inicial de la revista fue publicar los trabajos de graduación realizados por estudiantes e investigaciones del personal docente de la Escuela de Enfermería y de otros profesionales en el campo de la salud.
Se propuso como una innovación de la acción pedagógica, basada en la generalización de las redes teleinformáticas. De esta forma se aprovechaban las tecnologías de la información y la comunicación, para favorecer el aprendizaje interactivo y dinámico del estudiantado. Así como la divulgación de resultados de investigación en enfermería. Pero también permitiría ser utilizada por cualquier profesional que lo requiriera y en cualquier lugar del mundo.
Antes de que esta inquietud naciera, la Escuela de Enfermería de la Universidad de Costa Rica no contaba con ningún medio de difusión para su producción, como las tesis de licenciatura o de los trabajos de graduación. A nivel nacional, enfermería solo utilizaba la Revista del Colegio de Enfermeras. Además, la divulgación de las experiencias de la práctica de Enfermería, estaba limitado al interés de publicación de unos pocos profesionales en esta área.
La génesis de la revista fue una inspiración de la fundadora principal, la Dra. Ligia Rojas Valenciano, después de su egreso del Doctorado en Educación, de donde conoció involucró a la Mag. en Planificación Curricular, Ana Guzmán Aguilar, en esta aventura.
El inicio estuvo marcado por recursos humanos muy limitados, solo las dos docentes gestoras del proyecto que asumieron la edición y la dirección. Además, al inicio del proceso, asumieron las labores secretariales, junto a un diseñador gráfico y, luego, estudiantes becados, que abarcaron diversos trabajos dentro del proceso de edición.
Identificación sociodemográfica de familias con hijos de una institución educativa. Pereira, Risaralda. 2018
Authors: Velásquez Restrepo Luz Enith , Jaramillo Sanabria Liana Mayerly 
Published: July 2021

Introducción Este trabajo habla de la manera de analizar la población de la comuna de villasantana en instituciones educativas donde se estudió los integrantes década familia, la tipología familiar y los antecedentes.
Objetivo Identificar las características, antecedentes, sistemas de apoyo, factores de riesgos y la tipología de las familias con niños que asisten en un Centro de Desarrollo Infantil, con el fin de plantear intervenciones de Enfermería e Instrumentación quirúrgica en el municipio de Pereira, Risaralda 2017-2018.
Metodología Estudio descriptivo transversal aplicado a 154 familias con hijos en etapa de escolarización, al cual se les aplicó el instrumento de valoración familiar.
Resultados Se encontró una población femenina con el 55.4%, se observan familias conformadas entre 4 y 6 personas (50.9%), el 29 %, corresponde a hogares reconstituidos, lo que significa que existe la presencia importante de padrastro o madrastra al interior de las familias
Conclusión La intervención realizada fue satisfactoria para los objetivos planteados, estos datos evidencian que el cuidado de la familia es asumido por madres, tías o abuelas que llevan a sus hijos e hijas al centro de desarrollo integral de Tokio.
Fracaso del control de legalidad en la adjudicación de contratos públicos en Colombia
Authors: Heras Montes Felipe Andrés , Mendoza Vásquez Jhonny 
Published: July 2021

Con la promulgación de la Ley 80 de 1993 en Colombia, se consideró que sería la solución legal definitiva para el tema de la contratación pública, tópico de suma importancia para cualquier país, por tratarse del medio que tiene a la mano cualquier gobierno de turno para la implementación de sus políticas. El contrato público pasa a convertirse en una pieza fundamental o angular de la administración pública, sin él no se podrían ejecutar muchas de las obras que fueron trazadas en los Planes de Desarrollo. Pasados casi 20 años del nuevo siglo el problema con la legalidad acerca de los contratos se encuentra en entredicho, para muchos no ha mejorado, por el contrario, cada día se encuentran mayores dificultades al celebrar un contrato entre el Estado colombiano y los contratistas, incluso se ha prestado para motivar la corrupción en este país. Es esta situación la que conduce a preguntarse en que se está fallando para que la adjudicación de contratos presente tantos problemas.
Microcirculatory Liver Bloodstream in Hyperhomocysteinemia and Administration of Tautomeric Forms of Orotic Acid
Authors: Chuchkova N. N. , Pazinenko K. A. , Smetanina M. V. , Pazinenko O. A. , Panteleev K. E. , Chuchkov V. M. , Kormilina N. V. , Kanunnikova O. M. 
Published: July 2021

The aim of the study was to analyze the microvasculation of the liver in administration of tautomeric forms of orotic acid for a methionine-induced liver pathology to assess the efficacy of the modified drugs and the potentialof their clinical use.Material and methods. The study included 30 white outbred rats, that were simulated methionine induced hyperhomocysteinemia by the administration of methionine, dosage 0.15 g/100 g of the body we ight, via food during 4 weeks. Animals with hyperhomocysteinemia were divided into 4 groups: animals of group 1 received orotic acid (OA) in the initial form (oxo-tautomer), animals of group 2 received hydroxy–tautomer OA after mechanomodification for 1 hour, animals of group 3 received dihydroxy-tautomer OA after mechanomodification for 6 hours. Histological preparations of the liver were used to evaluate the area of hepatocytes; diameters and areas of the central vein, the interlobular vein and artery, the bile duct, and the Visotto coefficient were calculated.Results. Morphometric data of the hepatic microvascular bloodstream with simulated hyperhomocysteinemia evidenced a general increase in the diameter and area of blood vessels, changes affected the system of blood inflow and outflow at the organ level. Administration of OA had a normalizing effect on the liver bloodflow, but the effects were different: the most pronounced effect was detected in administration of the hydroxy-form of the preparation, this can be explained by a modificationin the dispersion of the preparation (without changing the crystal lattice), an increase in the rate of dissolution in water and aqueous solutions, an increasein the number of functionally active groups in the heterocycle of the hydroxy-form of OA. Thus, the hydroxy-tautomer of orotic acid had the greatest efficacy relating to vasodilation of microvessels of the liver bloodstream in hyperhomocysteinemia; the fact suggesting feasibility of its further study in the clinical environment.
​​Genetic Divergence in Leafy Mustard (Brassica juncea var. rugosa) Germplasm Grown under Tarai Condition of Uttarakhand
Authors: Bhandari Dhiraj , Singh Anita 
Published: July 2021

Background: Mustard represents a rich diversity and widely cultivated in 23 states and union territories of India. However, much of this diversity is concentrated in the Indo-Gangetic plains and the sub-mountain Himalayas. Genetic diversity plays a significant role in plant improvement because a hybrid between the lines of diverse origin usually display a greater heterosis than those between closely related ones which permit the selection of genetically divergent plants to obtain the desirable recombination of segregating generation. Therefore, the present study was undertaken to assess “Genetic Divergence in Leafy Mustard (Brassica juncea. var. rugosa) germplasm grown under Tarai condition of Uttarakhand” and to identify divergent parents for hybridization program, which would provide superior transgressive segregants from collected germplasm. Methods: The present investigation consisted of thirty-two genotypes of leafy mustard and the research was carried out at Vegetable Research Centre (VRC), G.B. Pant University of Agriculture and Technology, Pantnagar, U.S. Nagar (Uttarakhand) in rabi season of 2015-2016. Mustard genotypes were sown in randomized block design with three replications in field and data were observed for seventeen quantitative and qualitative characters. The estimation of genetic divergence was done with the help of Mahalonobis D2 statistic as suggested by Rao (1952). Cluster analysis by Tocher method for all the traits was done. Result: Thirty two germplasm of leafy mustard for different characters and grouped them into six clusters using Mahalanobis D2 statistic. The analysis revealed the maximum inter cluster distance was (20534.12) between cluster V and cluster VI so, we can create variation by inter mating genotypes from these two clusters to each other and the maximum intra cluster distance in cluster III (441.91) with six germplasm. It means we can intermate genotypes of this cluster with each other (2014/MGVAR-2, FS-13-1, FS-13-4, 2014/MGVAR-4, PRHC-12-9-1, PRHC-12-7-2, FS-13-3 and Pusa Sag 1) to create variation in next generations. The clustering pattern could be utilized in selection of parents for crossing and deciding the best cross combinations which may generate the highest possible variability for various traits.
Cytotoxicity test of 0,78% xanthone from mangosteen pericarp (Garcinia mangostana L.) and 0,2% chlorhexidine gluconate toward BHK-21 fibroblast cells
Authors: Ummah Afin Aslihatul , Setyowati Laksmiari , Suardita Ketut 
Published: July 2021

Background. Chlorhexidine gluconate is one of endodontic irrigants that has excellence capability to penetrate into dentin tubules and kill the pathogenic bacteria there. On the other hand, chlorhexidine gluconate has side effects to cause allergic reactions of the tissue and discoloration of the teeth. Xanthone from mangosteen pericarp can be considered as a natural alternative irrigant that usually has a good tolerance to the body. Purpose. The aim of this study compared the cytotoxicity between 0,78% xanthone from mangosteen pericarp and 0,2% chlorhexidine gluconate toward BHK-21 fibroblast cells. Methods. This study used experimental post-test only control group design. Xanthone from mangosteen pericarp preliminary cytotoxicity tested in various concentrations. Xanthone from mangosteen pericarp classified as a non-toxic concentration at 0,78%. Cytotoxicity of 0,78% xanthone from mangosteen pericarp compare with cytotoxicity of 0,2% chlorhexidine gluconate using MTT assay method. Cytotoxicity of material can be seen from % of cell viability. Viable cell measured by the result of optical density that read by ELISA reader 620 nm. Result. 0,78% xanthone from mangosteen pericarp showed lower cytotoxicity than 0,2% chlorhexidine gluconate toward BHK-21fibroblast cells. One-way ANOVA showed a significant difference between the study groups (P<0,05). Conclusion. 0,78% xanthone from mangosten pericarp showed lower cytotoxicity than 0,2% chlorhexidine gluconate toward BHK-21 fibroblast cells.
Ohmic heating for polyphenol extraction from grape berries: an innovative prefermentary process
Authors: Junqua Rémy , Carullo Daniele , Ferrari Giovanna , Pataro Gianpiero , Ghidossi Rémy 
Published: July 2021

High energy consumption is often required to increase the extraction of phenolic compounds from grapes during alcoholic fermentation. Processes such as thermovinification require significant temperature changes over a long period of time to ensure the diffusion of phenolic compounds from the grape skin layer to the must. In this study, the capability of the ohmic heating (OH) process (E = 55 V/cm, t = 60–90 s, T = 72 °C) to improve the extractability of valuable intracellular compounds from grape skins of Aglianico and Barbera grape matrices before the alcoholic fermentation stepAs similarly reported by Donsì et al. (2010), any tissue damage to grape skins occurring after the application of either conventional or ohmic heating was not found to influence the rate of fermentation. was investigated and compared with both untreated and conventional thermally (CH) treated (T = 72 °C, t = 90 s) samples. Total phenolics and antioxidant capacity were monitored during fermentation (10 days). In comparison to the conventional thermal treatment, the results showed that the phenolic compound content of musts was twice as high immediately after OH treatment. This process could drastically improve the classic prefermentary maceration (thermovinifications, cold macerations, etc.) time. In finished wines produced from the treated musts, the total polyphenolic content of OH wines was up to 17 % higher than that of CH wines, and 30 % higher than that of untreated wines. No differences in concentrations of total tannins and anthocyanins were observed between conventional and ohmic heated musts. However, an increase of 30 to 200 % for some aromatic esters was observed in wines from ohmic heated musts. Overall, the outcomes of this work proved that, in addition to the thermal effect, the moderate electric field (MEF) applied during ohmic heating has the potential to induce an instantaneous release of polyphenolic compounds due to the electroporation phenomenon of cell membranes, thus saving energy and reducing processing time.
Penelusuran dan Isolasi Fungi Tanah Muara Pelabuhan Besuki Serta Skrining Aktivitas Antibakteri Terhadap Pseudomonas aeruginosa ATTCC 27853
Authors: Kibthiyyah Mariatul , Triatmoko Bawon , Nugraha Ari Satia 
Published: July 2021

<p>Penyakit infeksi merupakan salah satu penyebab utama kematian di dunia. Terapi infeksi bakteri dengan antibiotik yang tidak tepat penggunaannya dapat menyebabkan resistensi. Penemuan antibiotik baru dapat berasal dari bahan alam, salah satunya fungi. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak etil asetat hasil fermentasi fungi khamir tanah muara terhadap <em>Pseudomonas aeruginosa.</em>Isolasi fungi tanah dilakukan menggunakan media <em>Potato dextrose Agar </em>(PDA) dilarutkan dalam air laut. Proses tersebut menghasilkan 7 isolat fungi kemudian disebut IS-PB-A1, IS-PB-A2, IS-PB-A3, IS-PB-T1, IS-PB-T2, IS-PB-B1, IS-PB-B2. Semua isolat fungi memiliki potensi dalam menghambat pertumbuhan bakteri dengan uji antagonis. Pengujian aktivitas antibakteri dilanjutkan menggunakan metode mikrodilusi. Aktivitas antibakteri disajikan dalam bentuk persen penghambatan. Hasil uji antibakteri dari tujuh ekstrak konsentrasi 100 µg/mL menunjukkan persen penghambatan tertinggi dari kode IS-PB-A2 (84,7 ± 1,4%) dan terendah dari kode IS-PB-T2 (30,5 ± 3,3 %). Senyawa yang berperan menghambat pertumbuhan bakteri dalam penelitian ini belum bisa dipastikan sehingga diperlukan penelitian lebih lanjut.</p>