bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of High Flow Nasal Cannula on the Coordination between Swallowing and Breathing in Postextubation Patients, a Randomized Crossover Study
Authors: Rattanajiajaroen Pornpan , Kongpolprom Napplika 
Published: June 2021

Abstract
Background: Timing of swallows in relation to respiratory phases is associated with aspiration events. Oxygen therapy possibly affects the timing of swallows, which may alter airway protective mechanisms.Objectives: To compare the coordination between swallowing and respiration during water infusion in post-extubation patients using high flow nasal oxygen(HFNO) with the coordination in those using low flow nasal oxygen(LFNO).Methods: We conducted a randomized controlled crossover study in post-extubation patients. The patients extubated within 48 hours were randomly assigned into two groups, namely HFNO and LFNO. The eligible patients in each group received either HFNO with FiO2 35%, flow 50 LPM and temperature 34˚ C or LFNO 5 LPM for 5 minutes. The coordination between swallowing and respiration was observed during continuous infusion of 10 ml of water in one minute for three times. Respiratory phases and swallowing were monitored using ECG-derived respiratory signals and submental EMG, respectively. The swallowing frequency and timing of swallows in relation to respiratory phases were recorded. The coordination between swallowing and respiration was classified into 4 patterns, namely I ,E ,I-E and E-I swallows. (I; inspiration and E; expiration) Subsequently, after the 5 minute washout period, the patients were switched to receive the other type of oxygen therapy with the same procedure. Wilcoxon Signed Ranks Test was used for statistical analysis.Results: A total of 22 patients with the mean age of 55.8 years were enrolled into the study. The major indication for invasive mechanical ventilation was pneumonia with the median duration of endotracheal intubation of 2.5 days. The median of total swallowing numbers (three minutes) were 18.5 in the HFNO period and 21 in the LFNO period (p = 0.158). The most common swallowing pattern was E swallow. The patients using HFNO had higher numbers of E-swallow pattern (74.3% in HFNO vs 67.6% in LFNO; p = 0.048) and lower numbers of I-swallow pattern (14.3% in HFNO vs 23.1% in LFNO; p = 0.044). The numbers of other swallowing patterns were not different between 2 groups.Conclusions: Compared with LFNO, HFNO significantly increased the E-swallow and decreased the I- swallow in post-extubation patients. The findings indicated that HFNO might reduce the risk of aspiration during the post-extubation period.
Evaluation of Prediction Effect of Perfusion Index for Supraclavicular Brachial Plexus Block in Children
Authors: Wang Jinxu , Deng Lingli , Xu Aijun 
Published: June 2021

Abstract
Background: Pulse perfusion index (PI) is a reflection of blood perfusion. It has been reported that PI can be used to evaluate the effect of nerve block, but currently it is mostly focused on awake adults. In pediatric general anesthesia, it has been reported that PI can evaluate the effect of sacral block, but there is a lack of relevant research on the effect of brachial plexus blocks (BPB).Methods/Design: This is a mono-center, prospective, single-blinded, randomized controlled trial (RCT). 104 children aged 1 month to 12 years who undergo upper limb surgery will be enrolled in this study. According to anesthesia induction and maintenance medication, they will be divided into propofol group and sevoflurane group. Record the PI values of the index finger and little finger on the blocked and non-blocked sides of supraclavicular brachial plexus block (SCB) in all children. First, analyze the two groups of patients with complete blockage respectively, and observe whether the PI values of the index finger and the little finger have the same changes by comparing the baseline values. Secondly, the cases of failed or partial block will be analyzed to understand the relationship between the PI values of the index and little fingers. Thirdly, a comparative analysis of nerve block cases in the sevoflurane and propofol groups will find that PI in what kind of general anesthesia can better judge the effect of SCB in children. So as to provide a theoretical basis for PI to estimate the effect of SCB under general anesthesia in children.Discussion: After sevoflurane or propofol administration, changes in PI after BPB may exist in different situations at different periods. PI values in the blocked and non-blocked sides may vary with the metabolism of anesthetics. The surgery time is about 1h or so and the effects of nerve block still exist, so the PI value changes on the blocking side and the contralateral side can basically rule out the influence of general anesthetics on the PI value. Trial registration: ClinicalTrials.gov NCT04216823. Registered on 15 July, 2020.
Radiomics Methods to Differentiate Metastasis and Primary Lung Cancer of Breast Cancer Patients in PET/CT
Authors: Zhou Xinglu , Peng Yunsong , Li Yingci , Zhang Jiarui , Liu Tianyi , Jiang Huijie , Zheng Jian 
Published: June 2021

Abstract
Purpose：Positron emission tomography (PET) with integrated computed tomography (PET/CT) is a whole-body imaging method providing information the entire body. When it was used in staging breast cancer patients, quite a few patients were found to have a second primary lung cancer(PLC), which was has few distinguishing features from breast cancer metastasis(MBC). Therefore, based on CT, LDCT and PET images, combined with pathological features, we established radiomics models to distinguish between MBC and PLC.Methods：We retrospectively collected CT, LDCT, and PET images, and pathology features of 100 breast cancer patients, including 60 metastases of breast cancer(MBC) and 40 primary lung cancers(PLC). The two radiologists manually drew a region of interest around the whole visible tumor in consensus. Python 3.8 and Pyradiomics toolkit are used to extract features from CT, LDCT, and PET. The linear discriminant analysis (LDA) classifier was used to build the radiomics model. The receiver operating characteristic (ROC) curve and area under the ROC curve (AUC) were used to evaluate the classification performance.Results：Total 12, 13, and 9 features were selected from the CT, LDCT, and PET respectively. The model based on the LDCT and PET obtained the same highest AUC (0.9479). The combination with CT and pathology features showed a highest AUC of 0.9583 with a sensitivity of 1.000 and a specificity of 0.8333. Conclusion：Overall, the results are encouraging that radiomics models based on CT, LDCT and PET can differentiate between MBC and PLC pathological features could significantly improve the AUC and ACC of CT model.
Prevalence of ophthalmological manifestations in pediatric and adolescent populations with Down syndrome: a systematic review of the literature
Authors: Muñoz-Ortiz Juliana , Charry-Sánchez Jesús David , Bechara-Arango Isabella , Blanco-Becerra Mariana , Talero-Gutiérrez Claudia , Gomez-Suarez Marcela , de-la-Torre Alejandra 
Published: June 2021

Abstract
Background: Down syndrome (DS) is a chromosomal anomaly that is characterized by an extra chromosome 21. Ophthalmological manifestations have a high prevalence in patients with DS.Purpose: To review the scientific evidence and estimate the prevalence of ophthalmological manifestations in the pediatric population with DS.Data Sources: Electronic databases including MEDLINE, Cochrane Library, EMBASE, ScienceDirect, and LILACS.Study Eligibility Criteria: Published observational studies with available and original data were included. Articles were excluded if the study design was a review, letter to the editor, case report, case series, or systematic review and if the subjects had ophthalmological manifestations secondary to other conditions.Participants and Interventions: Pediatric and adolescent population with DS and with ophthalmological evaluation.Study Appraisal and Synthesis Methods: A data collection form was designed in Excel. Five reviewers extracted relevant details about the design and results of each study. The quality of the studies was assessed by applying the tools of systematic reviews of prevalence and incidence of the Joanna Briggs Institute. We calculated the weighted prevalence of ophthalmological manifestations, considering only the studies reporting the measurement of each manifestation.Results: Twenty-two articles (from 15 countries, published during 1994–2020) were included in the present systematic review. Ocular manifestations were observed in 85% of the studied pediatric and adolescent populations with DS. The most frequent ones were slanting fissures, oblique fissures, epicanthus, and epiblepharon.Conclusion: The ocular manifestations in the pediatric and adolescent population with DS are varied, and some can irreversibly affect visual development. Screening of the pediatric population with DS should be conducted from the first months of age and continued annually.Systematic Review Registration Number: PROSPERO ID CRD42019127717
Handwashing Adherence and the Trajectory of COVID-19 Pandemic: Findings from 14 Countries
Authors: Szczuka Zofia , Abraham Charles , Baban Adriana , Brooks Sydney , Cipolletta Sabrina , Danso Ebrima , Dombrowski Stephan U. , Gan Yiqun , Gaspar Tania , Matos Margarida Gaspar , Griva Konstadina , Jongenelis Michelle , Keller Jan , Miah Mohammad Abdul Awal , Morgan Karen , Peraud William , Quintard Bruno , Shah Vishna , Schenkel Konstantin , Scholz Urte , Schwarzer Ralf , Siwa Maria , Szymanski Kamil , Taut Diana , Tomaino Silvia C. M. , Vilchinsky Noa , Wolf Hodaya , Luszczynska Aleksandra , Ma Jinjin , Knoll Nina 
Published: June 2021

Abstract
Background: The COVID-19 pandemic has affected people’s engagement in health behaviors, especially those that protect individuals from SARS-CoV-2 transmission, such as handwashing/sanitizing. Associations between the pandemic’s trajectory and engagement in the protective behavior of handwashing are unclear. This study investigated whether adherence to the World Health Organization’s (WHO) handwashing guidelines is associated with (i) total cases of COVID-19 morbidity/mortality accumulated since the onset of the pandemic, (ii) recent cases (country-level COVID-19 morbidity/mortality in the 14 days prior to data collection), (iii) increases/acceleration in recent cases (country-level COVID-19 morbidity/mortality in the previous 14 days minus cases recorded 14-28 days earlier), and (iv) stringency of the national containment-and-health policies (in the 7 days prior to data collection).Methods: The observational study (#NCT04367337) enrolled 6,064 adults residing in Australia, Canada, China, France, Gambia, Germany, Israel, Italy, Malaysia, Poland, Portugal, Romania, Singapore, and Switzerland. Data on cross-situational handwashing adherence were collected via an online survey (March–July 2020). Individual data were matched with the WHO daily reports of COVID-19 and indices of containment-and-health policies. Country-level human development index and sociodemographic variables were controlled.Results: Multilevel regression models indicated that as the total cases of COVID-19 morbidity and mortality grew higher, handwashing adherence decreased. As increases in recent cases of COVID-19 morbidity and mortality occurred, handwashing adherence increased. Higher levels of containment-and-health policy index were associated with lower handwashing.Conclusions: Research investigating protective behaviors should account for indicators of fluctuations of COVID-19 morbidity/mortality, besides accounting for time since the beginning of the pandemic.Trial Registration: Clinical Trials.Gov, #NCT04367337, first registration date: 29/04/2020
A New Sight In The Key Prognosis-Related Proto-Oncogene FYN In Hepatocellular Carcinoma Based On WCGNA Hub-Gene Screening Strategy
Authors: Huang Chenkai , Zhou Juanjuan , Nie Yuan , Guo Guihai , Wang Anjiang , Zhu Xuan 
Published: June 2021

Abstract
Background: Hepatocellular Carcinoma (HCC) is the third deadly cancer worldwide. More breakthroughs are needed in the clinical practice of liver cancer, and new treatment strategies are required to carry out to benefit patients. This study aims to screen out other significant differences in genes associated with LIHC and analyze its prognostic value further. Methods: Here, we use the TCGA-LIHC database and the profiles of GSE25097 from GEO to explore the differential co-expression genes in HCC tissues compared with para-tumor (or healthy) tissues. Then, we utilized WGCNA to screen out differential co-expression genes. Finally, we explored the function of FYN in HCC cells and xenograft tumor models.Results: We identified ten hub genes in the protein-protein interaction (PPI) network, but only three (COLEC10, TGFBR3, and FYN) of them seem to have a close-related to the prognosis. The expression of FYN was negatively correlated with the prognosis of HCC patients. The xenograft model showed that overexpression of FYN could significantly inhibit malignant tumor behaviors and promote tumor cell apoptosis.Conclusion: Thus, FYN may be central to the development of LIHC and maybe a novel biomarker for clinical diagnosis and treatment.
Development and Validation of a One-Step RT-qPCR Assay for Identifying Common Fusion Gene Transcripts Associated with the Prognosis of Mexican Children with B-Lineage Acute Lymphoblastic Leukemia
Authors: Mejía-Aranguré Juan Manuel , Mata-Rocha Minerva , Rangel-López Angelica , Núñez-Enríquez Juan Carlos , Jiménez-Hernández Elva , Morales-Castillo Blanca Angélica , Sánchez-Escobar Norberto , Sepúlveda-Robles Omar Alejandro , Bravata-Alcántara Juan Carlos , Nájera-Cortés Alan Steve , Pérez-Saldivar María Luisa , Flores-Lujano Janet , Duarte-Rodríguez David Aldebarán , de Anda Norma Angélica Oviedo , Verson Carmen Alaez , Martín-Trejo Jorge Alfonso , Campo-Martínez María de Los Ángeles Del , Muñoz-Medina José Esteban , González-Bonilla César Raúl , Cueto Maria de los Angeles Hernandez , Medina-Sansón Aurora , Amador-Sánchez Raquel , Peñaloza-González José Gabriel , Torres-Nava José Refugio , Espinosa-Elizondo Rosa Martha , Cortés-Herrera Beatriz , Flores-Villegas Luz Victoria , Merino-Pasaye Laura Elizabeth , Solís-Labastida Karina Anastacia , Velázquez-Aviña Martha Margarita , Santillán-Juárez Jessica Denisse , Gurrola-Silva Alma , García-Velázquez Alejandra Jimena , Echáurregui Gabriela Alicia Hernández , Rosas-Vargas Haydeé 
Published: June 2021

Abstract
The aims of the present study were to optimize the detection of common fusion gene transcripts associated with childhood B-ALL prognosis through the development and validation of a one-step RT-qPCR assay and to identify the prevalence of these genes in a cohort of pediatric patients attended in public hospitals in Mexico City. The one-step RT-qPCR assay was sensitive, specific, easy to use, fast and cost efficient. The standard curves were linear, with amplification efficiencies between 97-107%; coefficients of variation were 2.1-3.0% in reproducibility and 2.6-3.8% in repeatability, with agreement between two different laboratories. The prevalence of fusion gene transcripts was ETV6-RUNX1, 10.3%; TCF3-PBX1, 7.5%; BCR-ABL1p190, 3.6%; and KMT2A-AFF1, 2.8%. The prevalence of the ETV6-RUNX1 fusion was low, consistent with the findings in Hispanics. The KMT2A-AFF1 fusion was not exclusively present in infants, as we also found it in patients 4-16 years of age, in whom it was related to a poor prognosis. TCF3-PBX1 patients were associated with an intermediate outcome. The present study highlights the importance of the detection of common genetic fusions in Mexican children with ALL, taking into account that some have molecular subtypes associated with a poor prognosis.
Research on a Dynamic Equilibrium Mechanism of Core Layer Interests in the Mobile Medical Platform Business Ecosystem
Authors: Shenghua Zheng , Shijie Wang , Jue Chen 
Published: June 2021

Abstract
In recent years, with the development of the mobile Internet, big data and cloud computing, by aggregating platform ecological resources, mobile medical platforms such as the one operated by Ding Xiang Yuan have played an irreplaceable role in improving efficiency, optimizing resource allocation and promoting the transformation and upgrading of the medical industry. Despite this, most of the domestic mobile medical platforms in China still experience problems, such as an immature business model, stagnation of the interaction of knowledge and information among platform members, and weak platform competitiveness. Based on a review of platform and commercial ecosystems, this paper, by using the evolutionary game method and simulation, analyses the evolutionary stability strategy of operators, partners and users in the core layer of the platform during pre-flow and post-flow periods of a mobile medical platform; this study thereby constructs a benefit dynamic equilibrium model of a platform business ecosystem under the optimal decisions made by all parties involved in the platform. The research helps reveal the inherent law of the development of mobile medical platforms and provides recommendations for policy-making and strategy formulation in building an appropriate business ecosystem and achieving sustainable development in mobile medical platforms.
Optimal Load Balancing in Cloud using ANFIS and MGWO based Polynomial Neural Network
Authors: Chourasia Uday , Silakari Sanjay 
Published: June 2021

Abstract
In recent years, cloud computing provides a spectacular platform for numerous users with persistent and alternative varying requirements. Here providing an appropriate service is considered a major challenge in the heterogeneous environment. In the cloud environment, security and service availability are the two most significant factors during the data encryption process. In order to provide optimal service availability, it is necessary to establish a load balancing technique that is capable of balancing the request from diverse nodes present in the cloud. This paper aims in establishing a dynamic load balancing technique using the APMG approach. Here in this paper, we integrated adaptive neuro-fuzzy interference system-polynomial neural network as well as memory-based grey wolf optimization algorithm for optimal load balancing. The memory-based grey wolf optimization algorithm is employed to enhance the precision of ANFIS-PNN and to maximize the locations of the membership functions respectively. In addition to this, two significant factors namely the turnaround time and CPU utilization involved in optimal load balancing scheme are evaluated. In addition to this, the performance evaluation of the proposed MG-ANFIS based dynamic load balancing approach is compared with various other load balancing approaches to determine the system performances.
Phase II Feasibility Study of Adjuvant Chemotherapy With Docetaxel/Cisplatin/S-1 Followed By S-1 For Stage III Gastric Cancer
Authors: Hirahara Noriyuki , Matsubara Takeshi , Kaji Shunsuke , Yamamoto Tetsu , Hyakudomi Ryoji , Takai Kiyoe , Ishitobi Kazunari , Uchida Yuki , Tajima Yoshitsugu 
Published: June 2021

Abstract
BackgroundTo evaluate the feasibility, safety, and efficacy of postoperative adjuvant chemotherapy with docetaxel/cisplatin/S-1 (DCS) following S-1 therapy in patients with stage III gastric cancer after curative gastrectomy.Methods Patients with stage III gastric cancer who underwent D2 gastrectomy were enrolled. Adjuvant chemotherapy was initiated within 8 weeks of gastrectomy. The first cycle of chemotherapy consisted of S-1 monotherapy (day 1–14), followed by a 7-day rest period. Cycles 2 and 3 consisted of the following: S-1 (day 1–14) administration, followed by a 14-day rest period, and an intravenous infusion of cisplatin and docetaxel on days 1 and 15. After 2 cycles, S-1 was administered for up to 1 year.Results Thirty patients were enrolled between 2013 and 2017. Febrile neutropenia of grade 3 or higher was the most common hematological toxicity with 4 patients (13.3%). Other hematological toxicities of grade 3 or higher were as follows: neutropenia in 3 (10.0%), leukopenia in 3 (10.0%), and anemia in 2 (6.7%). Most frequent non-hematological toxicity of grade 3 was anorexia (n=4, 13.3%) and general fatigue (n=3, 10.0%); no grade 4 non-hematological toxicities were observed. Twenty-five patients (83.3%) completed 2 cycles of DCS treatment and 18 (60.0%) completed subsequent S-1 treatment for 1 year. The relative dose intensity of docetaxel and cisplatin was 0.86 and that of S-1 was 0.88. Conclusion The DCS regimen can be acceptable as an adjuvant chemotherapy and offers an effective postoperative treatment option for stage III gastric cancer patients.Trial registration number: UMIN000012785 Date of registry: 08/01/2014
The Effect of Transactional Analysis Training On Emotional Intelligence In Health Professions Students
Authors: Yean Seow Hui , Wu Mabel Huey Lu , Mohan Mandakini , Mamat Norul Hidayah binti , Kutzsche Hildegunn Ellinor , Pau Allan Kah Heng 
Published: June 2021

Abstract
BackgroundWe evaluated the effect of psycho-educational training in emotional intelligence (EI) and transactional analysis (TA) (TEITA) on EI in health professions undergraduates, post-training and at 1-month follow-up. MethodsA total of 34 participants participated in the study where 17 participants were in TEITA group and another 17 were in control group. A quasi-experimental nonrandomised, controlled cohort was conducted, in which participants in TEITA group were introduced to EI and TA concepts on a weekly basis for four weeks, at 90 minutes each time, and provided with opportunities for experiential sharing of emotions and coping mechanisms experienced in the previous week. Both TEITA and control groups received weekly EI and TA reading materials. All completed the 16-item Wong and Law EI Scale at baseline and post-training. Training group also completed the questionnaire at 1-month follow-up. Wilcoxon Signed Ranks and Mann Whitney tests were used to analyse within group and between group changes in EI scores. ResultsBaseline EI scores in TEITA group were lower than control group. On completion of TEITA, EI scores in TEITA group increased, and differences were not detected between groups. Within TEITA group, paired increases in all domains were statistically significant, whereas in the control group, paired increase was only detected in the domain addressing regulations of emotion (ROE). Pre to post-training increases in EI scores were statically significantly greater in TEITA compared to control groups. At the 1-month follow-up, EI were sustained. ConclusionThe psycho-educational training based on EI and TA is effective in enhancing EI in health professions students. Future research should investigate the effect of such training on observable inter-personal and socio-economic behaviours.