bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Welcome to the End of the World!”
Authors: Jiménez Jiménez Leonel Iván 
Published: October 2021

AbstractAs the COVID‐19 pandemic is shattering the world, it can also be considered a “dress rehearsal” for the next crisis: climate change. The pandemic showed the worst faces of the global hegemonic system, but the next crisis will signify a crisis that is unthinkable. The global discourse has been demonstrated as a fiction, as global treaties, organizations, and systems were not able to respond to the global crisis, leaving local communities to survive a global problem through their own means. After the failure of the global, we must turn to the local as a way of transforming every paradigm into a culture of life. Homodiversity – against hegemonic identities – needs to emerge. The existence of many coexisting identities, epistemologies, and ways of living must be recognized in order to imagine another reality after the pandemic. It is in the local arena that real transformation can be made. Ecumenism is transcendental in this task as a model of communitarian relationships that can also transform political and economic systems. Karl Barth’s ecumenical theology is of key importance.
Future applications of 3D bioprinting: A promising technology for treating recessive dystrophic epidermolysis bullosa
Authors: Popp Courtney M. , Miller William C. , Eide Cindy R. , Tolar Jakub 
Published: October 2021

AbstractThree‐dimensional (3D) bioprinting is a rapidly developing technology that has the potential to initiate a paradigm shift in the treatment of skin wounds arising from burns, ulcers and genodermatoses. Recessive dystrophic epidermolysis bullosa (RDEB), a severe form of epidermolysis bullosa, is a rare genodermatosis that results in mechanically induced blistering of epithelial tissues that leads to chronic wounds. Currently, there is no cure for RDEB, and effective treatment is limited to protection from trauma and extensive bandaging. The care of chronic wounds and burns significantly burdens the healthcare system, further illustrating the dire need for more beneficial wound care. However, in its infancy, 3D bioprinting offers therapeutic potential for wound healing and could be a breakthrough technology for the treatment of rare, incurable genodermatoses like RDEB. This viewpoint essay outlines the promise of 3D bioprinting applications for treating RDEB, including skin regeneration, a delivery system for gene‐edited cells and small molecules, and disease modelling. Although the future of 3D bioprinting is encouraging, there are many technical challenges to overcome–including optimizing bioink and cell source–before this approach can be widely implemented in clinical practice.
Development methodologies for ontology‐based knowledge management systems: A review
Authors: Mora Manuel , Wang Fen , Gómez Jorge Marx , Phillips‐Wren Gloria 
Published: October 2021

AbstractKnowledge management systems (KMS) are computer‐based systems highly valued in business organizations because they support knowledge management (KM) processes. Most KMS have been developed using non‐intelligent computer technology—that is, DMS, CMS, DBMS, and CIS—, and thus, they cannot provide advanced capabilities. Consequently, enhanced KMS using intelligent technologies of ontologies with inference engines—called ontology‐based knowledge management systems (OKMS)—have been proposed in the last three decades. Nowadays, however, the implementation of OKMS in real‐world settings is still scarce. Lack of comprehensive and systematic development methodologies including Project Management and Technical Systems Engineering processes—as the Systems and Software Systems Engineering standards propose—have been suggested as a factor that inhibits OKMS implementations. In this study, we review the OKMS literature (1990–2021 period)—from six seminal studies located using a research search engine—to assess OKMS development methodologies that can be considered comprehensive and systematic. Five methodologies were identified and assessed using an evaluation subset from the ISO/IEC/IEEE 15288:2015 Systems and Software Engineering standard. Two of them—CommonKADS and NeON—were found with a high comprehensive and systematic level and both are suggested for organizations interested in OKMS implementations, but none of them qualified as agile, which is a current development approach for systems and software systems. Hence, further empirical research toward the realization of comprehensive and systematic OKMSs development methodologies, including agile versions, is suggested for fostering the implementation of OKMS in real‐world settings.
Crack evolution law and failure mode of red sandstone under fatigue–creep interaction
Authors: Wang Ju , Li Jiangteng , Shi Zhanming 
Published: October 2021

AbstractTo explore the fracture characteristics of rock under the interaction of fatigue load and creep load, fatigue–creep interactive loading experiments were performed on red sandstone with prefabricated cracks. The crack evolution process and failure mode were analyzed using acoustic emission technology and digital image correlation. The results showed that crack growth mainly occurred in the fatigue loading stage; the crack evolution of the sample could be divided into three stages: nucleation and initiation (
), stable expansion (
), and unstable fracture (
). There were distinct differences in the crack propagation modes of the rock samples with different prefabricated crack angles. The relationship between the crack initiation angle and prefabricated crack angle was analyzed based on the maximum circumferential stress theory. Moreover, with an increase in the prefabricated crack angle, the rock sample gradually changed from compression–shear failure to tension–shear failure.
Experimental method for determining the fracture toughness of concrete based on the modified two‐parameter model and DIC technique
Authors: Qing Longbang , Cao Guorui , Guan Junfeng , Li Shuguang 
Published: October 2021

AbstractAn experimental method, based on the modified two‐parameter model and digital image correlation technique, was proposed for determining the mixed mode fracture toughness (KI+II) of concrete. Three‐point bending tests on notched concrete beam specimens of different sizes, maximum aggregate sizes, and aggregate volume contents were conducted, and the values of KI+II were evaluated considering the crack deflection. The values of KI+II and KI under mode I loading were compared. The results show that KI+II increases with the specimen size and gradually stabilizes. In addition, KI+II decreases with the maximum aggregate size, but the aggregate volume content has little effect on KI+II. Higher values of KI+II are presented after considering the effect of crack deflection. Only a monotonic loading process is required for the proposed method to determine KI+II.
Bitcoin intraday time series momentum
Authors: Shen Dehua , Urquhart Andrew , Wang Pengfei 
Published: October 2021

AbstractThis study examines intraday time series momentum in Bitcoin. Unlike stock markets, Bitcoin trades 24 h a day and therefore has not got a clear opening and closing period. Therefore, we use trading volume as a proxy for the market trading time and show that the first half‐hour positively predicts the last half‐hour return. We find that the first trading sessions with the highest volume or volatility are associated with the greatest predictability for intraday time series momentum. We also show that intraday momentum‐based trading yields substantial economic gains in terms of market timing and asset allocation, especially in periods of a market downturn in Bitcoin. Consistent with the finding in foreign exchange markets, our results also show that the Bitcoin intraday momentum is driven by liquidity provision rather than late‐informed trading.
“Let my hands be your hands”: Constructions of intimacy among Filipina migrants in the care of the elderly in Japan
Authors: Navallo Katrina 
Published: October 2021

AbstractThe activities of care are often regarded as intimate and highly dependent on personal, relational and cultural contexts of care provision. In this paper, I explore how migrant care workers who do not share in the cultural logic and norms understand and mediate the expectations of intimacy in care work with their personal meanings and values in caregiving. Through multiple in‐depth interviews with 50 Filipino care workers and 1‐month of intensive fieldwork in a long‐term care facility, this paper unpacks the meanings and negotiations of intimacy in the care work of Filipino migrants in Japan. This paper analyzes intimacy in four dimensions: spatial, cultural, corporeal, and relational. It finds that Filipina care workers understand and negotiate intimacy in the care of the elderly Japanese by embodying cultural intimacy, mediating vulnerability and maintaining boundedness, attuning with the aged body, and articulating familial care. The findings offer the possibility for transformative caring relations when migrant care workers exercise intimacy in their care of the elderly residents in the institutional setting.
Regulatory function of interferon‐inducible 44‐like for hepatitis B virus covalently closed circular DNA in primary human hepatocytes
Authors: Nosaka Takuto , Naito Tatsushi , Murata Yosuke , Matsuda Hidetaka , Ohtani Masahiro , Hiramatsu Katsushi , Nishizawa Tsutomu , Okamoto Hiroaki , Nakamoto Yasunari 
Published: October 2021

AbstractAimCuring hepatitis B virus (HBV) infection requires elimination of covalently closed circular DNA (cccDNA). Interferon (IFN)‐γ has noncytolytic antiviral potential; however, elimination of cccDNA could not be achieved. To enhance the regulatory effect, we comprehensively analyzed the host factors associated with cccDNA amplification and IFN‐γ and IFN‐α effects using an in vitro HBV infection system showing various transcription levels.MethodsPrimary human hepatocytes were infected with HBV using genomic plasmids carrying the basic core promoter mutation A1762T/G1764A and/or the precore mutation G1896A and treated with IFN‐γ and IFN‐α. Comprehensive and functional studies involving microarray and small interfering RNA analysis revealed the host factors related to cccDNA regulation.ResultsThe HBV infection system reproduced the HBV life cycle and showed various propagation levels. Microarray analysis revealed 53 genes correlated with the cccDNA levels. Of the 53 genes, expression of IFN‐induced protein 44‐like (IFI44L) was significantly upregulated by IFN‐γ and IFN‐α. The anti‐HBV effect of IFI44L is exerted regardless of IFN‐γ or IFN‐α by inhibiting the activation of nuclear factor‐κB and signal transducer and activator of transcription 1 pathways.ConclusionsUsing the in vitro HBV infection system, an IFN‐inducible molecule, IFI44L, associated with cccDNA amplification, was identified. These results suggest an innovative molecular strategy for the regulation of HBV cccDNA by controlling a novel host factor, IFI44L.
Data practices in quality evaluation and assessment: Two universities at a glance
Authors: Raffaghelli Juliana E. , Grion Valentina , de Rossi Marina 
Published: October 2021

AbstractAs the debate on data in the society and in education grows the attention on data‐trace as ‘primary material’ for governance, educational quality and innovation falls under the spotlights. In this context, HEIs have been put under pressure to adopt quantitative metrics and evaluation approaches enhancing the massive collection of trace data. Nonetheless, each university overall, and the academics specifically, might respond differently to this context of innovation. The present article aims to explore data practices in two higher education institutions. Two relevant areas for the imaginaries related to data and quantification were explored: (a) evaluation of quality in teaching and learning; (b) data to support assessment. The study is based on a survey distributed to the whole university teaching staff of two institutions. Descriptive and inferential statistics comparing multivariate sample means (MANOVA) were applied to 601 responses collected. The results indicated the prevalence of institutionally consolidated data practices relative to quality teaching evaluation, with fragmentation and isolation in some emerging data practices connected to decision‐making and teaching and learning. Moreover, each of the universities revealed distinct institutional profiles which could be put in connection with the organisational culture. The results are discussed in light of the potential strategies at the institutional level, particularly regarding faculty development as means to build a visible, contextualised data culture.
Using inpatient electronic medical records to study influenza for pandemic preparedness
Authors: Fuller Candace C. , Cosgrove Austin , Sands Kenneth , Miller Karla M. , Poland Russell E. , Rosen Edward , Sorbello Alfred , Francis Henry , Orr Robert , Dutcher Sarah K. , Measer Gregory T. , Cocoros Noelle M. 
Published: October 2021

AbstractBackgroundWe assessed the ability to identify key data relevant to influenza and other respiratory virus surveillance in a large‐scale US‐based hospital electronic medical record (EMR) dataset using seasonal influenza as a use case. We describe characteristics and outcomes of hospitalized influenza cases across three seasons.MethodsWe identified patients with an influenza diagnosis between March 2017 and March 2020 in 140 US hospitals as part of the US FDA's Sentinel System. We calculated descriptive statistics on the presence of high‐risk conditions, influenza antiviral administrations, and severity endpoints.ResultsAmong 5.1 million hospitalizations, we identified 29,520 hospitalizations with an influenza diagnosis; 64% were treated with an influenza antiviral within 2 days of admission, and 25% were treated >2 days after admission. Patients treated >2 days after admission had more comorbidities than patients treated within 2 days of admission. Patients never treated during hospitalization had more documentation of cardiovascular and other diseases than treated patients. We observed more severe endpoints in patients never treated (death = 3%, mechanical ventilation [MV] = 9%, intensive care unit [ICU] = 26%) or patients treated >2 days after admission (death = 2%, MV = 14%, ICU = 32%) than in patients treated earlier (treated on admission: death = 1%, MV = 5%, ICU = 23%, treated within 2 days of admission: death = 1%, MV = 7%, ICU = 27%).ConclusionsWe identified important trends in influenza severity related to treatment timing in a large inpatient dataset, laying the groundwork for the use of this and other inpatient EMR data for influenza and other respiratory virus surveillance.
Treatment and control of modifiable cardiovascular risk factors among patients with diabetes mellitus and hypertension in Inner Mongolia: A cross‐sectional study
Authors: Bi Yanqing , Tian Zixuan , Yan Wenyan , Liu Min , Zhao Yuqian , Bao Han , Yan Tao , Zhang Nan , Xia Yuan , Zhang Xingguang 
Published: October 2021

AbstractThe authors assessed treatment and control of blood glucose, blood pressure (BP), and blood lipids among patients from Inner Mongolia with diabetes mellitus (DM) and hypertension (HTN) and identified the modifiable factors associated with treatment and achievement of blood glucose, BP, and blood lipid targets. The authors used a multistage stratified cluster sampling method according to geographical location and level of economic development in Inner Mongolia. Among patients with DM and HTN, the crude rates of fasting plasma glucose (FPG) treatment and control was 30.76% and 4.73%, respectively. Crude rates of BP treatment and control were 50.81% and 8.70%, respectively. The authors found that treatment rates of HTN and DM and control rates of BP and FPG showed a gradually increasing trend with increased age. Among patients with DM and HTN, the likelihood of treatment for HTN and DM was significantly increased among participants who were older, non‐Mongolian, male, obese, smokers, and those with previous cardiovascular disease. The authors found that control of BP, FPG, and low‐density lipoprotein cholesterol was far from optimal among study participants. Medical and health departments in Inner Mongolia should take appropriate measures to reduce the burden of DM and HTN in the population, such as by promoting and improving the quality of HTN and DM treatment to achieve control goals and reduce the risk of cardiovascular disease.
Modified conditioning regimen with chidamide and high‐dose rituximab for triple‐hit lymphoma
Authors: Kang Junnan , Zhang Yizhuo , Ding Sa , Yasheng Kalbinur , Li Yueyang , Yu Yong , Wang Yafei , Tian Chen 
Published: October 2021

AbstractTriple‐hit lymphoma (THL), which is classified into high‐grade B‐cell lymphoma with rearrangements of MYC, BCL2 and BCL6, presents aggressive biological behaviour. High‐dose chemotherapy followed by autologous hematopoietic stem cell transplantation (auto‐HSCT) is considered to be one of the recommended treatment options. Here, we reported 3 THL patients received carmustine, etoposide, cytarabine and cyclophosphamide (BEAC) combined with chidamide and high‐dose rituximab conditioning regimen and found that this conditioning showed good efficacy and tolerance without increase of adverse events.
Cutaneous ischemia‐reperfusion injury is exacerbated by IL‐36 receptor antagonist deficiency
Authors: Tanaka Y. , Iwata Y. , Saito K. , Fukushima H. , Watanabe S. , Hasegawa Y. , Akiyama M. , Sugiura K. 
Published: October 2021

AbstractBackgroundLoss‐of‐function homozygous or compound heterozygous mutations in IL36RN, which encodes interleukin‐36 receptor antagonist (IL‐36Ra), has been implicated in the pathogenesis of skin disorders. However, the pathogenic role of IL‐36Ra in cutaneous ischemia‐reperfusion (I/R) injury remains unclear.ObjectivesWe investigated the role of IL36Ra in cutaneous I/R injury.MethodsWe examined I/R injury in Il36rn−/− mice. The area of wounds, numbers of infiltrated cells, apoptotic cells and neutrophil extracellular trap (NET) formation were assessed. The expression levels of various genes were analysed using real‐time RT‐PCR. The expression of high mobility group box 1 (HMGB1), an endogenous toll‐like receptor (TLR) 4 ligand, was confirmed using immunohistology, and serum HMGB1 levels were measured by ELISA. Cytokine production by stimulated cultured J774A.1 and HaCaT cells was examined.ResultsIL‐36Ra deficiency resulted in significantly delayed wound healing and increased neutrophil and macrophage infiltration into the wound tissues. Il36rn−/− mice had increased mRNA expression levels of CXCL1, CXCL2, CCL4, TNF‐α, TGF‐β, IL‐1β, IL‐6 and IL‐36γ relative to wild‐type mice. Apoptosis was identified in keratinocytes by TUNEL assay. HMGB1 expression in the I/R site was decreased in both keratinocytes and adnexal cells, while serum HMGB1 levels were significantly elevated after reperfusion. The mRNA levels of various cytokines, including IL‐1β, were elevated in J774A.1 cells through TLR4 signalling by HMGB1 stimulation. In addition, HaCaT cells stimulated with IL‐1β showed significantly increased CXCL1, TNF‐α, IL‐6, IL‐36β and IL‐36γ mRNA expression. Furthermore, NET formation was increased by IL‐36Ra deficiency. Finally, either the blockade of TLR4 signalling by TAK‐242 or inhibition of NET formation by Cl‐amidine normalized exacerbated I/R injury in Il36rn−/− mice.ConclusionsThis study indicated that IL‐36Ra deficiency exacerbates cutaneous I/R injury due to excessive inflammatory cell recruitment, NET formation, and excessive cytokine and chemokine production via the TLR4 pathway by HMGB1 released from epidermal apoptotic cells.
Biosecurity and the ornamental fish trade: A stakeholder perspective in England
Authors: Wood Louisa E. , Guilder James , Brennan Marnie L. , Birland Nicola J. , Taleti Virginia , Stinton Nicholas , Taylor Nick G. H. , Thrush Mark A. 
Published: October 2021

AbstractThe freshwater and marine ornamental fish industry is a primary route of hazard introduction and emergence, including aquatic animal diseases and non‐native species. Prevention measures are key to reducing the risk of hazard incursion and establishment, but there is currently little understanding of the biosecurity practices and hazard responses implemented at post‐border stages of the ornamental fish supply chain. This study addresses this knowledge gap, using questionnaires to collate information on actual biosecurity behaviours and hazard responses practised by ornamental fish retailers and hobbyist communities in England. Actual behaviours varied considerably within retailers and hobbyists, suggesting that reliance on preventative practices by individuals in the post‐border stages of the ornamental fish supply chain is likely to be ineffective in minimizing the risk of hazard incursion and establishment. Resources should be allocated towards improving and enforcing robust pre‐ and at‐border control measures, such as risk‐based surveillance of ornamental fish imports at border controls. In addition, these findings should be used to implement targeted awareness‐raising campaigns and help create directed training on biosecurity practices for individuals involved in the post‐border stages of the ornamental supply chain.
Osteology‐focused redescription and description of the blood‐feeding candirus Paracanthopoma parva and Paravandellia alleynei sp.n. (Trichomycteridae: Vandelliinae)
Authors: Henschel Elisabeth , Bernt Maxwell J. , Baskin Jonathan N. , Schmidt Robert E. , Lujan Nathan K. 
Published: October 2021

AbstractThis study resolves a significant impediment to the taxonomy of the Neotropical endemic hematophagous candirus by providing the first high‐resolution, CT‐based osteological descriptions of type and nontype specimens of Paracanthopoma parva, type species of the genus. We also describe the distinctive new species Paravandellia alleynei based on specimens that were previously misidentified as Parac. parva in the only taxonomic study of that species since its 1935 description. Paracanthopoma parva is distinguished from all nominal congeners by its parietosupraoccipital and caudal skeleton morphology and by various meristics, including numbers of teeth on median premaxilla, vertebrae, and procurrent and principal caudal‐fin rays. Paravandellia alleynei differs from both nominal congeners (Paravandellia oxyptera and Paravandellia phaneronema) by the unique morphology of its maxilla, mesethmoid and opercular apparatus, relative position of the pelvic‐ and anal‐fin origins, orientation of the opercular odontodes, and various meristics, including numbers of vertebrae, median premaxillary teeth, medial teeth on premaxilla, branchiostegal rays, opercular and interopercular odontodes, distal claw‐like premaxillary teeth, dorsal‐fin rays and dentary teeth. This is the first species of Paravandellia recognized from Guyana and the Essequibo River basin. It is currently known only from two type specimens from the lower Essequibo River basin and 43 nontype specimens from the upper Branco River basin. By providing the first skeletal observations for type specimens of the type species Parac. parva and for topotypic specimens of all three nominal species of Paravandellia, we clarify and confirm the diagnosis of Parac. parva and establish a robust foundation for ongoing taxonomic revisions of these two small‐sized and species‐poor, yet trans‐continentally distributed genera, both of which contain considerable unrecognized diversity.