bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel method for intelligent operation and maintenance of transformers using deep visual large model DETR + X and digital twin
Authors: Zhang Xuedong , Sun Wenlei , Chen Ke , Song Shijie 
Published: January 2025

AbstractTo achieve real-time monitoring and intelligent maintenance of transformers, a framework based on deep vision and digital twin has been developed. An enhanced visual detection model, DETR + X, is proposed, implementing multidimensional sample data augmentation through Swin2SR and GAN networks. This model converts one-dimensional DGA data into three-dimensional feature images based on Gram angle fields, facilitating the transformation and fusion of heterogeneous modal information. The Pyramid Vision Transformer (PVT) is innovatively adopted as the backbone for image feature extraction, replacing the traditional ResNet structure. A Deformable Attention mechanism is employed to handle the complex spatial structure of multi-scale features. Testing results indicate that the improved DETR + X model performs well in transformer state recognition tasks, achieving a classification accuracy of 100% for DGA feature maps. In object detection tasks, it surpasses advanced models such as Faster R-CNN, RetinaNet, YOLOv8, and Deformable DETR in terms of overall mAP50 scores, particularly demonstrating significant enhancements in small object detection. Furthermore, the Llava-7b model, fine-tuned based on domain expertise, serves as an expert decision-making tool for transformer maintenance, providing accurate operational recommendations based on visual detection results. Finally, based on digital twin and inference models, a comprehensive platform has been developed to achieve real-time monitoring and intelligent maintenance of transformers.
Design and numerical simulation of CuBi2O4 solar cells with graphene quantum dots as hole transport layer under ideal and non-ideal conditions
Authors: Panachikkool Muhammad , Aparna E. T. , Asaithambi Perumal , Pandiyarajan T. 
Published: January 2025

AbstractThe simulation of ideal and non-ideal conditions using the SCAPS-1D simulator for novel structure Ag/FTO/CuBi2O4/GQD/Au was done for the first time. The recombination of charge carriers in CuBi2O4 is an inherent problem due to very low hole mobility and polaron transport in the valence band. The in-depth analysis of the simulation result revealed that Graphene Quantum Dots (GQDs) can act as an appropriate hole transport layer (HTL) and can enhance hole transportation. The simulation was done under ideal and nonideal conditions. The non-ideal conditions include parasitic resistances, reflection losses, radiative, and Auger recombination whereas the ideal condition was studied without the inclusion of any losses. Under ideal conditions, the cell Ag/FTO/CuBi2O4/GQD/Au exhibited a photovoltaic (PV) parameter such as open circuit voltage (Voc), short circuit current (Jsc), fill factor (FF), photo conversion efficiency (PCE) are 1.39 V, 25.898 mA/cm2, 90.92%, and 32.79%, respectively. The effect of various cell parameters such as the thickness of the absorber layer, HTL layer, and FTO, acceptor and defect density, the bandgap of the absorber and HTL layer, series and shunt resistance, back and front contact materials, radiation and Auger recombination of the absorber layer, reflection losses on the efficiency of the proposed cell is analysed. The drastic reduction in all PV parameters was observed under non-ideal conditions and the PV parameters are Voc (1.22 V), Jsc (2.904 mA/cm2), FF (86.3), and PCE of 3.06%. The charge kinetics such as impedance, conductivity, and capacitance plots, and possible reasons for reductions in PV parameters are discussed in detail.
Very low prevalence of Plasmodium falciparum histidine-rich protein 2 (pfhrp2) gene deletion in the Brazil, Venezuela, and Guyana tri-border
Authors: Pereira Mascarenhas Maria Eduarda , Louzada Jaime , Amorim Rosa Renato , de Assis Gabriela Maíra Pereira , Satiko Kano Flora , Oliveira-Ferreira Joseli , de Sousa Tais Nobrega 
Published: January 2025

AbstractRapid Diagnostic Tests (RDTs) have been an important diagnostic tool for detecting P. falciparum malaria in resource-limited settings. Most tests are designed to detect the Histidine-rich Protein 2 (HRP2). Parasites lacking pfhrp2 and its homologous pfhrp3 have been reported in several regions, with prevalence reaching 100% in certain areas. To better characterize P. falciparum isolates circulating in the Brazil-Venezuela-Guyana tri-border region, we performed a comprehensive analysis of 365 samples collected between 2016 and 2018. Molecular and immunological methods were employed to detect HRP2 and confirm pfhrp2/3 deletions. Our findings point to a low prevalence (1%) of pfhrp2-deleted parasites confirmed by the lack of HRP2 detection. Among false-negative HRP2-RDT tests (6%), most were attributed to low parasite densities. A merozoite surface protein 2 (msp2)-based intra-host diversity analysis suggested overall low genetic diversity. The pattern of HRP2 sequences resembled that has been previously described in areas along the Brazil and French Guiana border. In conclusion, we have found a low prevalence of pfhrp2-deleted parasites in the north-central Guiana Shield, which contrasts with the findings reported at the Peru border. Continued surveys are necessary to monitor the prevalence of pfhrp2 deletion in this area characterized by a high number of cross-border malaria cases.
Regulation of meristem and hormone function revealed through analysis of directly-regulated SHOOT MERISTEMLESS target genes
Authors: Lechon Tamara , Kent Nicholas A. , Murray James A. H. , Scofield Simon 
Published: January 2025

AbstractThe Arabidopsis Knotted1-like homeobox (KNOX) gene SHOOT MERISTEMLESS (STM) encodes a homeodomain transcription factor that operates as a central component of the gene regulatory network (GRN) controlling shoot apical meristem formation and maintenance. It regulates the expression of target genes that include transcriptional regulators associated with meristem function, particularly those involved in pluripotency and cellular differentiation, as well as genes involved in hormone metabolism and signaling. Previous studies have identified KNOX-regulated genes and their associated cis-regulatory elements in several plant species. However, little is known about STM-DNA interactions in the regulatory regions of target genes in Arabidopsis. Here, we identify and map STM binding sites in the Arabidopsis genome using global ChIP-seq analysis to reveal potential directly-regulated STM target genes. We show that in the majority of target loci, STM binds within 1 kb upstream of the TSS, with other loci showing STM binding at more distal enhancer sites, and we reveal enrichment of DNA motifs containing a TGAC and/or TGAT core in STM-bound target gene cis-regulatory elements. We further demonstrate that many STM-bound genes are transcriptionally responsive to altered levels of STM activity, and show that among these, transcriptional regulators with key roles in meristem and hormone function are highly represented. Finally, we use a subset of these target genes to perform Bayesian network analysis to infer gene regulatory associations and to construct a refined GRN for STM-mediated control of meristem function.
Age-related morphological changes of the pubic symphyseal surface: using three-dimensional statistical shape modeling
Authors: Kim Yuyoung , Lee Kang-Woo , Lee Sookyoung , Woo Eun Jin , Hu Kyung-Seok 
Published: January 2025

AbstractComputational analysis of the pubic symphyseal surface is widely used for accurate age estimation, offering quantitative precision through the detection of subtle morphological changes. However, these methods often lack insights into the underlying morphological changes across different age groups. To bridge this gap, the study utilizes statistical shape modeling (SSM), a versatile tool capable of describing diverse morphological variations within populations. This study aimed to elucidate the direction and extent of these morphological changes, identify the contributing factors, and pinpoint key variations crucial for distinguishing between age groups. Computed tomography (CT) scans of 252 subjects from the National Forensic Service of South Korea were employed, subjected to preprocessing and landmark-based alignment. Through this approach, the study visualized and validated significant age-related morphological changes and highlighted the shape variations essential for differentiating between consecutive age groups. This study holds significance in elucidating the intricate nature of age-related morphological changes in the pubic symphyseal surface. Thus, these findings can serve as valuable cornerstones for enhancing age-at-death estimation techniques in forensic anthropology.
Differential effects of structurally different lysophosphatidylethanolamine species on proliferation and differentiation in pre-osteoblast MC3T3-E1 cells
Authors: Makiyama Fumiaki , Kawase Shiori , Omi Aoi William , Tanikawa Yusuke , Kotani Taishi , Shirayama Teruki , Nishimura Naoyuki , Kurihara Taiga , Saito Naoto , Takahashi Jun , Uemura Takeshi 
Published: January 2025

AbstractLysophosphatidylethanolamine (LPE) is a bioactive lipid mediator involved in diverse cellular functions. In this study, we investigated the effects of three LPE species, 1-palmitoyl LPE (16:0 LPE), 1-stearoyl LPE (18:0 LPE), and 1-oleoyl LPE (18:1 LPE) on pre-osteoblast MC3T3-E1 cells. All LPE species stimulated cell proliferation and activated the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) 1/2. MAPK/ERK1/2 activation by 16:0 LPE and 18:1 LPE was inhibited by the Gq/11 inhibitor YM-254890, while activation by 18:0 LPE was blocked by the Gi/o inhibitor pertussis toxin. Intracellular Ca2+ transients were triggered by 16:0 LPE and 18:1 LPE but not by 18:0 LPE, with YM-254890 suppressing these responses. These results suggest that 16:0 and 18:1 LPE act via Gq/11-coupled G protein coupled receptors (GPCRs), and 18:0 LPE acts via Gi/o-coupled GPCRs. Furthermore, receptor desensitization experiments suggested that each LPE acts through distinct GPCRs. Interestingly, 18:0 LPE suppressed osteogenic differentiation, reducing mineralization, alkaline phosphatase activity, and osteogenic gene expression, whereas 16:0 LPE and 18:1 LPE had no such effects. These results suggest the physiological significance of LPEs in bone formation and indicate that different LPE species and their receptors play distinctive roles in this process.
Association between systemic immune inflammation index and cataract incidence from 2005 to 2008
Authors: Li Xiang , Du Guo-lei , Wu Shi-Nan , Sun Yi-qing , Zhang Si-Qi , Zhang Zhi-Jie , Tang Jia-feng 
Published: January 2025

AbstractThe objective of this study is to investigate the association between the Systemic Immune-Inflammation Index (SII) and cataracts. This cross-sectional study analyzed data from the 2005–2008 NHANES to examine the relationship between the SII and cataract prevalence. Covariates included age, race/ethnicity, gender, education level, marital status, Body Mass Index (BMI), smoking, alcohol consumption, hypertension, hyperlipidemia, and diabetes. Multivariable logistic regression was used to assess the association, while spline curve fitting explored potential non-linear relationships. Threshold analysis identified critical inflection points. To address age-related bias, Propensity Score Matching (PSM) was performed, aligning cataract patients with comparable non-cataract individuals for further evaluation. Our study included 3,623 participants, of whom 730 (20.15%) were diagnosed with cataracts. After adjusting for all covariates, multivariable logistic regression analysis demonstrated that elevated levels of the SII were significantly associated with increased odds of cataracts (Model1: OR = 1.56; 95%CI [1.33–1.85]; Model2: OR = 1.55; 95%CI [1.32–1.84]; Model3: OR = 1.57; 95%CI [1.33–1.86]). In the spline curve fitting model, the relationship between ln-SII and cataract prevalence was non-linear (P < 0.001), with a critical inflection point identified at an SII of 428.38. SII levels remained significantly associated with cataract prevalence following PSM adjustments (Model 1: OR = 1.48; 95% CI [1.21–1.80]; Model 2: OR = 1.48; 95% CI [1.21–1.80]; Model 3: OR = 1.46; 95% CI [1.20–1.78]). Elevated SII levels are associated with a higher prevalence of cataracts, underscoring the pivotal role of systemic inflammation in cataract development. These findings indicate that SII could serve as a valuable biomarker for assessing cataract risk, further emphasizing the significance of managing systemic inflammation as a potential strategy for cataract prevention.
Identification of deposits from modern and ancient large tsunamis by means of environmental DNA
Authors: Shinozaki Tetsuya , Iguchi Akira , Nishijima Miyuki , Goto Kazuhisa , Fujino Shigehiro 
Published: January 2025

AbstractWe examined the potential of environmental DNA (eDNA) for identifying tsunami deposits in the geological record using lake-bottom sediments in the Tohoku region, Japan. The presence of eDNA from marine organisms in a lacustrine event deposit provides very strong evidence that the deposit was formed by an influx of water from the ocean. The diverse DNA assemblage in the deposit formed by the 2011 Tohoku-oki tsunami included DNA of marine origin indicating that eDNA has potential as an identifying proxy for tsunami deposits. Subsequently, we examined the applicability of eDNA for recognizing paleo-tsunami events using the deposits formed by the 869 CE Jogan tsunami and a prehistoric event (2400–2900 cal year BP). The taxa detected in the tsunami deposits were markedly different from those of the background sediments. Many taxa that were represented in the Jogan tsunami deposit were also detected in the layer immediately above the tsunami deposit. This layer was indistinguishable from the overlying peat by visual observation, but the eDNA results suggest that it is likely to be a muddy tsunami deposit. The results of this study indicate that eDNA has the potential to elucidate the origin of event deposits that have been difficult to identify.
All-electrical recursive generation and time-domain mode division multiplexing of Hermite–Gaussian pulses for optical, THz and RF links
Authors: Yu Xiaonan , Meier Janosch , Mandal Paulomi , Hosni Mohamed I. , Venugopalan Abhinand , Wang Lingfei , Schneider Thomas 
Published: January 2025

AbstractSpace division multiplexing (SDM) with Hermite Gaussian (HG) modes, for instance, can significantly boost the transmission link capacity. However, SDM is not suitable in existing single mode fiber networks, and in long-distance wireless, microwave, THz or optical links, the far-field beam distribution may present a problem. Recently it has been demonstrated, that time domain HG modes can be employed to enhance the link capacity. However, implementing this method in wireless or fiber-based transmission systems is impractical due to the need for highly complex setups involving specialized lasers, wave shapers and other advanced devices. We propose a simple and fully electrical time-domain mode-division-multiplexing (TD-MDM) method based on the recursive generation of Hermite–Gaussian (HG) modes. It utilizes Gaussian pulse sequences, sawtooth signals, RF multipliers, adders, amplifiers, and Mach–Zehnder modulators for efficient multiplexing and demultiplexing. We show the time and bandwidth performance of 4 multiplexed orthogonal modes in transmitting 8 Gbps communication data (4 × 2 Gbit/s), demonstrating the feasibility of the recursive generation and multiplexing technique for TD-MDM with HG modes. The data rates were restricted by our experimental capabilities. With state-of-the-art equipment the method can easily be scaled to the terabit per second range.
Congestion avoidance in 6G networks with V Gradient Geocast Routing Protocol
Authors: Sahoo Arundhati , Tripathy Asis Kumar 
Published: January 2025

AbstractThis is a moment of heavy necessity for a dependable internet connection in the modern world, which is used to engage in business dealings, communicate with other people, entertain oneself, and lead a daily life. Therefore, a Wi-Fi 6 router must have an internal wire-free connection within a house or business. However, as they depend on the weather and are installed in ways that expose them to infiltration, they are vulnerable. The increased demand for Internet services for business, communication, and leisure activities due to poor weather puts added stress on the network, slowing down the speeds and increasing congestion. The bottom line is to prioritize traffic and lower latency and convergence time to improve network performance under less-than-ideal weather conditions. This will be realized using highly technical approaches such as the mini-batch gradient descent optimization algorithm for network optimization and the V Gradient Geocast Routing Protocol for effective routing. The proposed enhanced congestion avoidance model with V Gradient Geocast Routing Protocol in 6G networks under unfavorable weather conditions attains an accuracy of 98.85%.
Microstructure and mechanical properties of highly porous Hastelloy-X nickel superalloy produced by a space holder approach
Authors: Bętkowska Aleksandra , Podsiadło Marcin , Polkowska Adelajda , Włoch Grzegorz , Polkowski Wojciech 
Published: January 2025

AbstractHighly porous nickel-based superalloys appear as attractive candidates to be applied e.g. as seals in gas turbine engines instead of honeycomb structures. Among various methods of producing open-porous materials, a space holder approach provides number of benefits regarding economic and ecological aspects of production. In this work, the pioneering results of microstructure and mechanical properties analyses of highly porous Hastelloy-X nickel superalloy produced by the space holder approach, are presented. The materials were fabricated by using spherical fine Hastelloy-X powders and carbamide particles as batch materials. A multi-step powder metallurgy and thermomechanical processing was applied to produce open porous samples having a total volumetric porosity of 50, 60 and 70%. The produced materials were subjected to non-destructive (X-ray computed tomography) and metallographic inspections. Mechanical properties of the porous Hastelloy-X samples were examined in static room temperature compression tests, to discuss the effect of obtained porosity on compressive response.
Prevalence of metal implants among US adults aged 40 years and older
Authors: Wang Qiu-Fu , Tang Yu-Chen , Liao Hao-Ran , Lei Miao , Dong Wei , Liu Ze-Yu , Hao Jie , Hu Zhen-Ming 
Published: January 2025

AbstractMetal implants are commonly used in clinical practice. However, little is known regarding the prevalence of metal implants. Therefore, this study aimed to evaluate the prevalence of metal implants in the United States (US) among individuals aged ≥ 40 years. This study conducted a serial cross-sectional analysis of US adults aged ≥ 40 years who participated in the National Health and Nutrition Examination Survey (NHANES) (2015–2016 and 2017–March 2020). Self-reported questionnaires were used to assess whether the participants had metal implants inside their bodies. The primary outcome was the prevalence of metal implants among adults aged 40 years and older. Furthermore, weighted logistic regression analysis was employed to determine the changes in the prevalence of metal implants from 2015 to March 2020. Moreover, this study investigated the variation in metal implant prevalence by demographic factors based on the pooled NHANES cycles. All analyses were conducted based on 3,736 participants from the NHANES 2015–2016 and 6,387 participants from the NHANES 2017–March 2020. This study observed a high prevalence of metal implants among adults aged 40 and older (2015–2016: 27.23%; 2017–March 2020: 31.53%). Moreover, the results of the weighted logistic regression analysis showed that the prevalence of metal implants significantly increased from 2015 to March 2020, especially among older individuals, men, and White individuals. In addition, the results of the weighted logistic regression analysis indicated that the metal implant prevalence differed by age and race/ethnicity, in which older individuals and White individuals showed a significantly higher prevalence of metal implants than younger individuals and non-White individuals, respectively. There was a high prevalence of metal implants among US adults aged 40 and older, and the prevalence of metal implants significantly increased from 2015 to March 2020. Therefore, more attention needs to be paid to this special population, and it may be necessary to ensure accessibility and affordability and assess the potential long-term health impacts of metal implants, considering the increased prevalence of metal implants.
lncRNA CHAF1B-2 contributes to the tumorigenesis of gastric cancer by activating the Wnt/β-catenin pathway
Authors: Tian Shao-Qi , Shen Jun-Jie , Sun Dao-Ping , Chen Wen-Ming 
Published: January 2025

AbstractLnc-CHAF1B-2, a newly discovered long noncoding RNA (lncRNA), plays a significant role in the evolution and prognosis of diverse neoplasms. However, its role in the development of gastric cancer is not yet fully understood. Using bioinformatics analysis of gastric cancer RNA-seq data from The Cancer Genome Atlas (TCGA) database, we investigated the expression of lnc-CHAF1B-2 in gastric carcinoma and its associated molecular signalling pathways. Verification through an array of in vivo and in vitro experiments—namely, EdU incorporation, flow cytometry, trans-well migration and invasion assays, subcutaneous tumour formation in nude mice, and western blot analysis—was conducted. We revealed notable upregulation of lnc-CHAF1B-2 in gastric cancer tissues. Furthermore, a positive correlation was detected between lnc-CHAF1B-2 levels and the occurrence of distant metastases in patients, which was inversely related to their prognostic outlook and survival rates. Moreover, our findings confirmed that lnc-CHAF1B-2 enhanced the proliferation, invasion, and migration of gastric cancer cells while inhibiting apoptosis both in vitro and in vivo. Mechanistically, lnc-CHAF1B-2 promoted the progression of gastric cancer through activating the Wnt/β-catenin signalling pathway. Thus, lnc-CHAF1B-2 and its regulation of the Wnt/β-catenin signalling pathway have emerged as prospective therapeutic targets in gastric cancer management.
Fascicle differentiation of upper extremity nerves on high-resolution ultrasound with multimodal microscopic verification
Authors: Pušnik Luka , Radochová Barbora , Janáček Jiří , Saudek František , Serša Igor , Cvetko Erika , Umek Nejc , Snoj Žiga 
Published: January 2025

AbstractThis study aimed to compare the fascicular anatomy of upper limb nerves visualized using in situ high-resolution ultrasound (HRUS) with ex vivo imaging modalities, namely, magnetic resonance microscopy (MRM), histological cross-sections (HCS), and optical projection tomography (OPT). The median, ulnar, and superficial branch of radial nerve (n = 41) were visualized in 14 cadaveric upper limbs using 22-MHz HRUS. Subsequently, the nerves were excised, imaged with different microscopic techniques, and their morphometric properties were compared. HRUS accurately differentiated 51–74% of fascicles, while MRM detected 87–92% of fascicles when compared to the referential HCS. Among the compared modalities, HRUS demonstrated the smallest fascicular ratios and fascicular cross-sectional areas, but the largest nerve cross-sectional areas. The probability of a fascicle depicted on HRUS representing a cluster of multiple fascicles on the referential HCS increased with the fascicular size, with some differences observed between the larger median and ulnar nerves and the smaller radial nerves. Accordingly, HRUS fascicle differentiation necessitates cautious interpretation, as larger fascicles are more likely to represent clusters. Although HCS is considered the reference modality, alterations in nerve cross-sectional areas or roundness during sample processing should be acknowledged.