bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dapagliflozin exerts anti-apoptotic effects by mitigating macrophage polarization via modulation of the phosphoinositide 3-kinase/protein kinase B signaling pathway
Authors: Xiong Sheng-Xi , Huang Lin-Juan , Liu Han-Shuang , Zhang Xiao-Xiao , Li Min , Cui Yu-Bing , Shao Chen , Hu Xiao-Lei 
Published: December 2024

BACKGROUND
Macrophages are central to the orchestration of immune responses, inflammatory processes, and the pathogenesis of diabetic complications. The dynamic polarization of macrophages into M1 and M2 phenotypes critically modulates inflammation and contributes to the progression of diabetic nephropathy. Sodium-glucose cotransporter 2 inhibitors such as dapagliflozin, which are acclaimed for their efficacy in diabetes management, may influence macrophage polarization, thereby ameliorating diabetic nephropathy. This investigation delves into these mechanistic pathways, aiming to elucidate novel therapeutic strategies for diabetes.
AIM
To investigate the inhibitory effect of dapagliflozin on macrophage M1 polarization and apoptosis and to explore its mechanism of action.
METHODS
We established a murine model of type 2 diabetes mellitus and harvested peritoneal macrophages following treatment with dapagliflozin. Concurrently, the human monocyte cell line cells were used for in vitro studies. Macrophage viability was assessed in a cell counting kit 8 assay, whereas apoptosis was evaluated by Annexin V/propidium iodide staining. Protein expression was examined through western blotting, and the expression levels of macrophage M1 surface markers, inflammatory cytokines, and apoptotic factors were quantified using flow cytometry, enzyme linked immunosorbent assay, and quantitative real-time polymerase chain reaction analyses.
RESULTS
Dapagliflozin attenuated M1 macrophage polarization and mitigated apoptosis in the abdominal macrophages of diabetic mice, evidenced by the downregulation of proapoptotic genes (Caspase 3 ), inflammatory cytokines [interleukin (IL)-6, tumor necrosis factor-α, and IL-1β], and M1 surface markers (inducible nitric oxide synthase, and cluster of differentiation 86), as well as the upregulation of the antiapoptotic gene BCL2 . Moreover, dapagliflozin suppressed the expression of proteins associated with the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway (PI3K, AKT, phosphorylated protein kinase B). These observations were corroborated in vitro , where we found that the modulatory effects of dapagliflozin were abrogated by 740Y-P, an activator of the PI3K/AKT signaling pathway.
CONCLUSION
Dapagliflozin attenuates the polarization of macrophages toward the M1 phenotype, thereby mitigating inflammation and promoting macrophage apoptosis. These effects are likely mediated through the inhibition of the PI3K/AKT signaling pathway.
Association between body mass index and lumbar spine volumetric bone mineral density in diabetic and non-diabetic patients
Authors: Lv Fang , Cai Xiao-Ling , Zhang Xiu-Ying , Zhou Xiang-Hai , Han Xue-Yao , Li Yu-Feng , Ji Li-Nong 
Published: December 2024

BACKGROUND
The association between body mass index (BMI) and bone mineral density (BMD) has shown inconsistent results, varying by sex and skeletal site. Despite normal or elevated bone mass, individuals with type 2 diabetes have an increased risk of hip and vertebral fractures.
AIM
To assess lumbar spine trabecular volumetric BMD (vBMD) across different BMI categories in individuals with and without diabetes.
METHODS
This cross-sectional study included 966 men over 50 years old and 1001 postmenopausal women from the Pinggu Metabolic Disease Study. The vBMD of lumbar vertebrae 2 through 4 was measured using quantitative computed tomography. Total adipose tissue, subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and lumbar skeletal muscle area were also quantified.
RESULTS
In men with obesity (P = 0.038) and overweight (P = 0.032), vBMD was significantly higher in the diabetes group compared to non-diabetic men. After adjusting for age and sex, no significant saturation effect between BMI and BMD was found in participants with diabetes or in women without diabetes. However, a BMI threshold of 22.33 kg/m² indicated a saturation point for vBMD in non-diabetic men. Independent predictors of vBMD in men included age (r = -0.387, P < 0.001), BMI (r = 0.130, P = 0.004), and VAT (r = -0.145, P = 0.001). For women, significant predictors were age (r = -0.594, P < 0.001), BMI (r = 0.157, P = 0.004), VAT (r = -0.112, P = 0.001), and SAT (r = -0.068, P = 0.035).
CONCLUSION
The relationship between BMI and trabecular vBMD differs in individuals with and without diabetes. Overweight and obese men with diabetes exhibit higher vBMD.
Clinical significance of Ki-67 in patients with lung adenocarcinoma in situ complicated by type 2 diabetes
Authors: Chen Ke , Wang Ge , Hu Jing-Cheng , Zhou Ying-Yi , Ma Hai-Tao 
Published: December 2024

BACKGROUND
The increasing number of type 2 diabetes mellitus (T2DM) patients leads to higher rates of morbidity and mortality related to lung cancer.
AIM
To investigate the utility of the proliferating cell nuclear antigen Ki-67 in patients with lung adenocarcinoma in situ (AIS) complicated by T2DM.
METHODS
One hundred patients with AIS and T2DM (group A), 100 patients with AIS alone (group B), and 60 patients with benign lung lesions (group C) admitted to the Department of Thoracic Surgery and Endocrinology of the First Affiliated Hospital of Soochow University from November 2021 to December 2022 were enrolled. Ki-67 expression was compared among the groups.
RESULTS
Group A had significantly higher levels of fasting plasma glucose (FPG), total cholesterol (TC), total triglyceride, low-density lipoprotein cholesterol, glycosylated hemoglobin (HbA1c), and insulin than groups B and C (P < 0.01). Meanwhile, group B had higher insulin levels than group C (P < 0.01). Group A exhibited a significantly higher average Ki-67 positivity rate than group B (P < 0.01). The Ki-67 positivity rate in group A was 86.87%, while the positivity rate in group B was 77%. Ki-67 was positively correlated with FPG (P < 0.01) and HbA1c levels (P < 0.01). Ki-67, FBG, insulin, HbA1c, high-density lipoprotein cholesterol and TC were independent factors for patients with AIS complicated by T2DM.
CONCLUSION
Ki-67 expression was higher in patients with AIS complicated by T2DM than in patients with AIS alone. Therefore, detecting the Ki-67 level might assist in the diagnosis of AIS in patients with T2DM.
Las vidas paralelas de dos emprendedores inmigrantes: Torcuato Di Tella y Ezra Teubal
Authors: Aisenberg Igal , Rein Raanan 
Published: December 2024

Este artículo arroja nueva luz sobre los derroteros de Ezra Teubal, el inmigrante judío de origen alepino que fue un protagonista de referencia en la industria textil argentina, y Torcuato Di Tella, que creó el emporio industrial más emblemático de la Argentina a mediados del siglo XX. No pretende comparar dos empresas alineadas en sectores radicalmente diferentes. Tampoco aspira a confrontar el talento o el carácter individual de ambos. La brecha entre ellos abarca rasgos culturales, formación profesional, afinidades políticas y sobre todo identidades étnicas y religiosas. Sin embargo, la pertenencia a una misma generación y la condición de inmigrantes y emprendedores durante el mismo período formativo de la industrialización en Argentina, revelan varios puntos en común. El texto se centra en el desarrollo de las empresas que fundaron hasta la muerte prematura de Di Tella en 1948. Aunque Di Tella y Teubal no hayan sido rechazados por las élites de sus propios grupos étnicos, los dos no ejercieron funciones en instituciones líderes de sus respectivas comunidades. Marginados o auto-marginados, ambos eran rara aves, el primero por su aislamiento de los grupos económicos italianos dominantes, el segundo por su enajenación idiosincrática y cultural del 90% de la judeidad argentina de origen askenazí. En cualquier caso, sin haber renegado sus profundas identidades italianas y judías, su liderazgo empresarial no tuvo manifestaciones de liderazgo étnico.
La Universidad de Buenos Aires y el Consejo Nacional de Educación: los instrumentos para el gobierno de la instrucción pública en los Centenarios
Authors: Guic Laura S. 
Published: December 2024

El trabajo de investigación profundiza los instrumentos de gobierno que implementa el Consejo Superior de la Universidad de Buenos Aires y el Consejo Nacional de Educación, hacia el novecientos, un período en el que se consolida el sistema educativo argentino. Para el diseño e implementación de las políticas públicas educativas, la dirigencia formula y ejecuta estrategias de intervención, por un lado, e intervenciones estratégicas, por otro, a través de instrumentos de gobierno, definidos en forma primigenia como las herramientas con las que se articulan ambas dimensiones de la política. Se emplea como metodología el enfoque rizomático que enlaza, en el examen de las políticas, el estudio de los instrumentos de gobierno, la hemerografía y la reconstrucción biográfica para las trayectorias políticas. La utilización articulada favorece el análisis y luego la comparación primera entre dos publicaciones entendidas como instrumentos de gobierno, que son producidas por dos organismos gubernamentales de la educación. Las fuentes primarias son la Revista de la Universidad de Buenos Aires y El Monitor de la Educación Común. Los datos exhiben que las revistas oficiales y educativas han sido instrumentos de gobierno que permiten conocer formas de instrumentar el funcionamiento de las políticas y las trayectorias de quienes las formulaban y publicaban.
Television and Women Empowerment: How Pakistani Private Channels portray Pakistani Women
Authors: Maleeha Hashmi  
Published: December 2024

The continuous decline of Pakistan on Global Gender Gap Index calls for serious measures to curb the situation. Entertainment media appears as one among the major stake holders in this regard and women Empowerment is major tool to reduce the gap between genders. This research was designed to find the patterns in which women empowerment is being showcased through Pakistani Private Channels. The existing literature in the niche suggests the use of somehow stereotypical yard to measure empowerment i.e., level of education and job status. However, indicators to measure women empowerment, devised by institutions who are putting their effort to curb the gender gap such as World Bank, are often ignored. This researcher has utilised those indicators to measure women empowerment in Pakistani entertainment industry. ARY Digital, GEO Entertainment and HUM TV were selected for the research. Their prime-time dramas were analysed to explore the approaches of these channels. One of the key findings includes absence of political empowerment from drama content. Child bearing decisions were found as least attended indicator of women empowerment. Majority of the characters coded as empowered belonged to ARY.
THE PRESENCE OF SALMONELLA ENTERICA AND LISTERIA MONOCYTOGENES ON POULTRY SLAUGHTER PLANT EQUIPMENT AFTER SANITATION PROCEDURES
Authors: Vidaković Knežević Suzana , Pelić Miloš , Žekić Marina , Knežević Slobodan , Vranešević Jelena , Ljubojević Pelić Dragana , Savić Sara 
Published: December 2024

The persistence of Salmonella enterica and Listeria monocytogenes on poultry slaughter plant equipment and food contact surfaces is an important factor for food contamination. Both bacterial foodborne pathogens can form biofilms and survive stress caused by sanitation procedures. The aim of this study was to evaluate the degree of contamination of poultry slaughter plant equipment by Salmonella enterica and Listeria monocytogenes after cleaning and disinfection. Samples were taken from four areas of the poultry slaughter plant (i.e., slaughter line, cutting line, meat processing, and packing area) and evaluated using real-time quantitative PCR. In total 32.5% of samples were positive for Salmonella enterica, while 37.5% were positive for Listeria monocytogenes. Both Salmonella enterica and Listeria monocytogenes were most detected on the slaughter line, mostly after evisceration. Evisceration, or removal of the birds’ internal organs, may present a high-risk step of cross-contamination due to gut breakage and transfer of the contents to the skin, other carcass surfaces, and on equipment surfaces. This study indicates that poultry slaughter plant equipment may harbor foodborne pathogens like Salmonella enterica and Listeria monocytogenes after applying standard sanitation procedures.
An Analysis of President Joko Widodo's Economic Diplomacy from 2014 to 2024: Results in Foreign Investment and Global Trade Volume
Authors: Setiawan Asep 
Published: December 2024

This research aims to analyze the economic diplomacy strategies undertaken by President Joko Widodo’s administration from 2014 to 2024, focusing on their effectiveness in enhancing Indonesia’s trade volume, attracting foreign direct investment (FDI), and addressing global economic challenges. By examining key initiatives, this study explores the interplay between trade agreements, regulatory reforms, and international partnerships that shaped Indonesia’s economic trajectory. The theoretical framework of this research is rooted in the concept of economic diplomacy, which encompasses the use of economic policies as instruments of foreign policy to advance national interests. Economic diplomacy involves negotiating trade agreements, attracting FDI, and leveraging international partnerships to foster economic growth and geopolitical influence. This study employs qualitative research methods, analyzing secondary data from scholarly journals, government reports, trade and FDI statistics, and publications by international institutions such as the World Bank and the IMF. The findings indicate that President Joko Widodo’s economic diplomacy led to significant advancements in Indonesia’s economic standing. Between 2014 and 2022, Indonesia saw a notable increase in FDI attributed to regulatory reforms such as the Omnibus Law, which simplified business processes and reduced bureaucratic hurdles. Additionally, Indonesia’s active participation in multilateral agreements like the Regional Comprehensive Economic Partnership (RCEP) expanded trade opportunities. This paper contributes to the field of international economic diplomacy by providing a comprehensive analysis of Indonesia’s strategies under President Joko Widodo. It offers valuable insights for policymakers in Indonesia and other emerging economies, demonstrating how domestic reforms, international trade agreements, and strategic partnerships can bolster economic growth.
Dampak Instagram terhadap Implementasi Metode Al-Arba’in Finnahwi Wassorfi Wallughah di Pondok Pesantren Baitussakhi
Authors: Fatimatuzzahra Fatimatuzzahra , Gumiandari Septi 
Published: December 2024

Metode dan media adalah hal yang sangat berpengaruh dalam proses pembelajaran, oleh karena itu guru hendaknya menggunakan metode serta media yang memadai cara belajar para muridnya. Oleh karena itu tujuan penelitian ini untuk mengenal metode al-arba’in finnahwi wassorfi wallugoh, mengetahui dampak Instagram sebagai media pembelajaran terhadap implementasi metode al-arba’in finnahwi wassorfi wallugoh, serta mengetahui peningkatan intelektual para santri dengan metode al-arba’in finnahwi wassorfi. Metode penelitian yang digunakan adalah studi kasus dengan pendekatan kualitatif , melibatkan 3 santri dan 1 pengajar di pondok pesaantren Baitussakhi yang dipilih secara purposive. Hasil penelitian menunjukkan bahwa adanya sebuah peningkatan intelektual para santri setelah mengikuti atau mempelajari nahwu shorof dengan metode al-arba’in finnahwi wassorfi wallugoh dengan Instagram sebagai media belajarnya dengan adanya kemajuan yaitu adanya penambahan wawasan, dan dapat mengimplementasikan apa yang telah santri pelajari. Adapun dampak negatif dari penggunaan Instagram dalam pembelajaran metode al-arba’in finnahwi wassorfi wallugoh yaitu penggunaan kuota yang boros menjadi kendala bagi para pelajar dalam menggunakan Instagram sebagai media pembelajaran. Salah satu solusinya adalah dengan menyediakan fasilitas wifi di pondok pesantren Baitussakhi. Kesimpulan dari penelitian ini menunjukkan bahwa integrasi teknologi dalam pembelajaran dapat meningkatkan efektivitas pendidikan di pondok pesantren. Implikasinya, penyediaan fasilitas internet yang memadai menjadi kebutuhan mendesak agar pembelajaran berbasis media sosial dapat berlangsung tanpa hambatan. Studi ini merekomendasikan pengembangan metode pembelajaran berbasis teknologi lainnya untuk meningkatkan kualitas pendidikan Islam di era digital.
Nutrient balance and productivity of crop rotations as affected by their structure and fertilisation
Authors: Ivanina V. V. , Prokopiuk T. P. 
Published: December 2024

Purpose. To investigate the influence of fertilisation systems on the productivity of short crop rotations and the formation of the balance of nutrients in the soil.
Methods. Long-term field and analytical.
Results. The productivity of crop rotations and the balance of nutrients in the soil depending on their structure and fertilisation systems are presented. It was established that organic-mineral fertilisation systems formed the highest fodder productivity of crop rotations and the best indicators of the balance of nutrients in the soil.
Conclusions. Application of N53Р42K42 + 6.7 t of manure per 1 ha of arable land in crop rotation provided the highest fodder productivity of 9.2 t/ha with an advantage over control without fertilisers of 3.8 t per 1 ha of crop rotation area. The application of conventional and alternative organic-mineral fertilisation systems was determined to be effective in row crop rotation: the productivity of crop rotation was 8.4 and 8.3 tons of fodder units per 1 ha of crop rotation area, respectively. Organic-mineral fertilisation systems formed an optimal balance of nitrogen in grass and grain and row crop rotations with the intensity of the balance of 94–95% and 100–103%, respectively. In the grain and row crop rotation, the nitrogen balance was negative at the intensity of 82–84%. In all crop rotations, the combined application of organic and mineral fertilisers contributed to the accumulation of phosphorus in the soil and formed a positive phosphorus balance at an intensity of 103–115%. None of the fertilisation systems provided a positive balance of potassium in the soil. The best indicators of potassium balance in crop rotations were formed by applying N53Р42K42 per 1 ha of arable land + by-products with a potassium deficit of 33–41 kg/ha of the crop rotation area and the intensity of its balance of 73–78%.
The name of the compound and allelopathic effect of metabolites produced by common ragweed (Ambrosia artemisiifolia L.)
Authors: Storozhyk L. I. , Mykhailovyn Yu. M. 
Published: December 2024

Purpose. To identify the phytochemical composition of the aboveground biomass of Ambrosia artemisiifolia L., the effect of its root exudates on major crops within agroecosystems, and the competitiveness of this weed species compared to other plants.
Methods. Allelopathic, chemical, physiological-biochemical, analytical, and statistical methods.
Results. The biomass of A. artemisiifolia contains a high concentration of essential physiologically active components, with coumarins being the most prevalent at 2.97%. The roots of A. artemisiifolia release protocatechuic acid, n-hydroxybenzoic acid, vanillic acid, syringic acid, n-coumaric acid, and ferulic acid into the rhizosphere. Phytotoxic extracts from the vegetative organs of A. artemisiifolia reduced seed germination in winter pea by an average of 37–50%, in maize by 27–40%, in sorghum by 17–22%, and in sugar beet by 12–28%. Root phytotoxic extracts and rhizosphere soil extracts significantly decreased seed germination in the studied crops: in winter pea by 71% and 78%, respectively, in maize by 42% and 38%, respectively, in sugar beet by an average of 26%, and in sorghum by 33% and 16%. Sunflower demonstrated the highest resistance, with seed germination reduced by only 7%, 5%, and 4% when treated with phytotoxic extracts from the stems, leaves, and inflorescences of A. artemisiifolia, respectively. Phytotoxic extracts from the soil and roots reduced sunflower seed germination by 11% and 6%, respectively. The highest competitiveness against the allelopathically active components of the weed species was exhibited by yellow mustard (Sinapis alba), sorghum, and creeping couch grass (Elymus repens), as their phytotoxic soil extracts reduced A. artemisiifolia seed germination by 75%, with creeping couch grass and sorghum extracts reducing germination by 88% and 68%, respectively.
Conclusions. Water extracts from the vegetative and generative organs of A. artemisiifolia contain significant amounts of physiologically active components that impact the quality of seed germination in the studied crops. It was found that sunflower seeds are resistant to the allelopathically active substances of the A. artemisiifolia. Yellow mustard, sorghum, and creeping couch grass demonstrate resistance to the phytotoxic components of A. artemisiifolia, due to their high levels of phytochemical compounds capable of inhibiting seed germination of this highly allelopathic weed.
Edukasi kepada Masyarakat terkait Pola Makan Sehat untuk Penderita Gastritis
Authors: Sabrina Alifa , Aisyah Siti 
Published: December 2024

Gastritis atau yang biasa disebut dengan maag ialah kondisi dimana lapisan dinding lambung (mukosa lambung) mengalami inflamasi atau peradangan Persentase dari angka kejadian gastritis di Indonesia menurut WHO adalah 40,8%. Angka kejadian gastritis pada beberapa daerah di Indonesia cukup tinggi dengan prevalensi 274,396 kasus dari 238,452,952 jiwa penduduk. Studi di Indonesia menyatakan 550 pasien yang melakukan pemeriksaan endoskopi, 44,7% diantaranya memiliki gastritis akut. Selain disebabkan oleh bakteri helicobacter pylori, gastritis ini juga bisa diakibatkan dari penyakit lain yaitu penggunaan obat NSAID (Nonsteroidal anti- inflammatory drug) seperti aspirin dan ibuprofen, konsumsi alkohol yang berlebihan, penggunaan kokain, stress fisik, dan merokok. Kegiatan Pengabdian kepada Masyarat (PkM) ini bertujuan untuk mengedukasi masyarakat dalam menambah pengetahuan terkait pola makan sehat untuk penderita gastritis. Metode yang digunakan dalam menganalisis data hasil kegiatan ini menggunakan metode kuantitatif untuk melihat peningkatan pengetahuan masyarakat. Sampel atau responden dalam kegiatan ini merupakan perwakilan warga di kelurahan durensawit yang diambil menggunakan Accidental Sampling dengan jumlah responden sebanyak 34 responden. Pengambilan data dilakukan menggunakan kuesioner pola makan sehat untuk penderita gastritis. Hasil pengolahan data menunjukkan bahwa sebelum kegiatan penyuluhan dilakukan sebanyak 12% responden berpengetahuan baik, 21% responden berpengetahuan cukup sebanyak dan sebanyak 67% responden berpengetahuan kurang. Setelah kegiatan penyuluhan dilakukan sebanyak 62% responden berpengetahuan baik, 23% responden berpengetahuan cukup sebanyak dan sebanyak 15% responden berpengetahuan kurang. Berdasarkan hasil tersebut dapat disimpulkan bahwa penyuluhan yang dilakukan mampu meningkatkan pengetahuan peserta mengenai pola makan sehat untuk penderita gastritis.