bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Value of PD-L1 Expression on Immune Cells or Tumor Cells for Locally Advanced Esophageal Squamous Cell Carcinoma in Patients Treated With Neoadjuvant Chemoradiotherapy
Authors: Huang Ta-Chen , Liang Cher-Wei , Li Yu-I , Guo Jhe-Cyuan , Lin Chia-Chi , Chen Ya-Jhen , Cheng Ann-Lii , Hsu Chih-Hung 
Published: June 2021

Abstract
Purpose Programmed death-ligand 1 (PD-L1) expression may influence the prognosis of patients with localized esophageal cancer. The current study compared the prognostic value of PD-L1 expression between tumor cells and immune cells. Methods Archival esophageal tumor tissue samples were collected from patients who received paclitaxel and cisplatin-based neoadjuvant chemoradiotherapy (CRT) for locally advanced esophageal squamous cell carcinoma (ESCC) in 3 prospective phase II trials. PD-L1 expression on tumor and immune cells was examined immunohistochemically by using the SP142 antibody and scored by 2 independent pathologists. The association of PD-L1 expression with patients’ outcomes was analyzed using a log-rank test and Cox regression multivariate analysis. Results A total of 100 patients were included. PD-L1 expression on tumor cells was positive (≥1%, TC-positive) in 55 patients; PD-L1 expression on immune cells was high (≥5%, IC-high) in 30 patients. TC-positive status was associated with poor overall survival (OS) (HR: 1.63, P = .035), whereas IC-high status was associated with improved OS (HR: 0.44, P = .0024). Multivariate analysis revealed that TC-positive, IC-high, and performance status were independent prognostic factors for progression-free survival and that IC-high and performance status were independent factors for OS. Furthermore, the combination of IC-high and TC-negative status was associated with the optimal OS, whereas that of TC-positive and IC-low status was associated with the worst OS. Conclusion PD-L1 expression on tumor and immune cells may have different prognostic value for patients with locally advanced ESCC receiving neoadjuvant CRT. A combination of these 2 indexes may further improve the prognostic prediction.
“I Need the Company of My Peers”: A Mixed-method Study Among Community-dwelling Elderly in China Running Title: I Need the Company of My Peers
Authors: Fu Jingjing , Huang Jinyu , Hong Yan , Liu Siqi , Zhong Zhu , Kong Dehui , Tan Jing , Luo Yu 
Published: June 2021

Abstract
Background: To study the importance of peers in Chinese older adults’ lives and explore their peer interaction perceptions. Methods: A mixed-methods study was undertaken among the community-dwelling elderly in Chongqing, China. First, a self-administered nomination survey was carried out (n=340) to detect current peer network features. Second, we conducted semi-structured interviews (n=19) to explore the experience and perspectives on peer interaction of the elderly. Results: 67.10% of social network members who have the most contact with participants were peers, and 85.47% of these peers were within the age difference of 10 years old compared with participants. In the interview, three themes were revealed: motivation, preference and barriers, and impact of peer interaction on the individual's health.Conclusions: Peers make up the vast majority of Chinese older people’s social networks. Older people’s preference for the company of peers deserves greater attention and community support to improve their health and well-being.
Comparative Analysis of Small Moleclues and Natural Plants Compounds as Therapeutic Inhibitors Targeting RdRp and Nucleocapsid Proteins of SARS CoV 2: An in Silico Approach
Authors: POLEBOYINA PAVAN KUMAR 
Published: June 2021

Abstract
Nucleocapsid protein and RNA-dependent RNA polymerase (RdRp) activity in viral structural membrane, transcription and replication has been recognized as an attractive target to design novel antiviral strategies. The essential feature of the N protein of SARS COV 2 is to bind to the viral genome to promote the exact folding of the hammerhead ribozyme averting unproductive RNA confirmations and lead them to right into a helical capsid shape or RNP complex, whose packaging is crucial to viability. RdRp is an essential enzyme that helps in RNA synthesis by catalyzing the RNA template-dependent development of phosphodiester bonds. RdRp makes a complex with two cofactors nsp7 and nsp8 to play a key role in RNA synthesis, transcription and replication of the SARS-CoV-2. In our study we used small molecules and natural plants compounds as therapeutic inhibitors targeting RdRp and N proteins of SARS COV 2. Their structures were geometrically optimized and energetically minimized using Hyperchem software. Molecular docking was performed using Molegro virtual docker and top ligands were selected based on MolDock score,Rerank score and H-bonding energy. Our results showed that 9 compounds against N protein and 7 compounds against RdRp protein forming better inhibitory effect with most lowest MolDock score − 285.68kcal/mol and − 201.5kcal/mol respectively. we hope that these small molecules and natural plants compounds can inhibit the viral enzymes and helps the patients in reducing specific symptoms of SARS-CoV-2 infection. However in vivo experimental studies and clinical trials need to get that more favorable result.
Efficient trapping of cesium ions in water by titanate nanosheets: experimental and theoretical studies
Authors: Lin Luyao , Li Ye , Wan Jie , Liu Cong , Wang Xiaoli , Yin Yixin 
Published: June 2021

Abstract
In recent years, TNS has attracted wide attention because of its simplicity in synthesis and high efficiency in ion exchange. The adsorption of cesium ions in aqueous solution by TNS was investigated in this study. Results show that the removal rate of Cs (I) is about 88% when pH = 5.00 ± 0.05, C0 = 10 ppm and CTNS = 0.1 g/L. The adsorption equilibrium is reached in about 20 minutes and best fits the pseudo-second order model, R2 = 0.9998; compared with the Freundlich isotherm adsorption model and Temkin model, the Langmuir model has the best fitting effect, R2 = 0.9903. The fitting results show the maximum adsorption capacity of TNS for Cs (I) is 200.00 mg/g. The main adsorption mechanism of TNS to cesium ion is ion exchange. Therefore, TNS can be used as a potential adsorbent for effectively adsorbing Cs-containing wastewater.
Bioinformatics Analysis of Autophagy-related lncRNAs in Esophageal
Carcinoma
Authors: Fan JunBai , Wu Dan , Ding Yi 
Published: June 2021

Background:
Esophageal carcinoma (ESCA) is a malignant tumor with high
invasiveness and mortality. Autophagy has multiple roles in the development of cancer; however,
there are limited data on autophagy genes associated with long non-coding RNAs (lncRNAs) in
ESCA. The purpose of this study was to screen potential diagnostic and prognostic molecules and
to identify gene co-expression networks associated with autophagy in ESCA.

Methods:
We downloaded transcriptome expression profiles from The Cancer Genome Atlas and
autophagy-related gene data from the Human Autophagy Database, and analyzed the co-expression
of mRNAs and lncRNAs. In addition, the diagnostic and prognostic value of autophagy-related
lncRNAs was analyzed by multivariate Cox regression. Furthermore, Kyoto Encyclopedia of
Genes and Genomes analysis was carried out for high-risk patients, and enriched pathways were
analyzed by gene set enrichment analysis.

Results:
The results showed that genes of high-risk patients were enriched in protein export and
spliceosome. Based on Cox stepwise regression and survival analysis, we identified seven
autophagy-related lncRNAs with prognostic and diagnostic value, with the potential to be used as a
combination to predict the prognosis of patients with ESCA. Finally, a co-expression network
related to autophagy was constructed.

Conclusion:
These results suggest that autophagy-related lncRNAs and the spliceosome play
important parts in the pathogenesis of ESCA. Our findings provide new insight into the molecular
mechanism of ESCA and suggest a new method for improving its treatment.
Hemp Seeds, Flaxseed, and Açaí Berries: Health Benefits and Nutritional
Importance with Emphasis on the Lipid Content
Authors: Magalhães Pedro , Domingues Rosário M. , Alves Eliana 
Published: June 2021

Abstract:
Some plant seeds and berries have gained increased recognition due to their wide
variety of bioactive compounds. Many of these foods are rich in lipids with high nutritional
value, of which n-3 and n-6 essential fatty acids stand out. However, knowledge of the chemical
composition and biological activity of these compounds and their value as a source of
healthy lipids is far from being fully explored.
The benefits of the intake of hemp seeds, flaxseed, and açaí berries, considered functional
foods, have been compiled in this review. Likewise, their general chemical composition will be
described to evaluate their relevance in a healthy diet, highlighting their lipid components and
health lipid indices.
The fibres and essential fatty acids of hemp seeds and flaxseed and the antioxidant properties
of açaí berries provide them protective roles against several chronic non-communicable diseases
and represent significant beneficial effects that add value to these healthy natural products.
More research is needed to deepen the knowledge on their lipids’ molecular composition and
bioactivity.
Synergistic Role of Thymoquinone on Anticancer Activity of 5-Fluorouracil in Triple
Negative Breast Cancer Cells
Authors: Zheng Meiling , Mei Zhiqiang , Junaid Md. , Tania Mousumi , Fu Junjiang , Chen Han-Chun , Khan Md. Asaduzzaman 
Published: June 2021

Background:
Triple Negative Breast Cancer (TNBC) is considered as the most deadly subtype of breast
cancer, because of heterogeneity, less treatment options and resistance to chemotherapy.

Objective:
To find out an efficient chemotherapeutic options, in this study we have investigated the combined therapy
of 5-Fluorouracil (5-FU) and thymoquinone (TQ) against TNBC cell lines BT-549 and MDA-MB-231.

Methods:
We have tested 5-FU and TQ alone and in combination (5-FU + TQ) to observe the cellular growth, cell
cycle and apoptosis status of BT-549 and MDA-MB-231 cells. Also we have measured the mRNA level expression of
genes related to cell cycle and apoptosis.

Results:
Experimental results suggest that both of 5-FU and TQ are effective in controlling cell growth, cell cycle and
inducing apoptosis, but their combination is much more effective. 5-FU was found to be more effective in controlling
cell growth, while TQ was found to be more effective in inducing apoptosis, but in both cases, their combination was
most effective. TQ was found more effective in increasing and BAX/BCL-2 ratio, while 5-FU was more effective in
inhibiting thymidylate synthase. They showed significant increasing effects on caspases and P53 and decreasing effect
on CDK-2, where their combination was found most effective.

Conclusions:
Thus, TQ and 5-FU probably showed synergistic effect on both of cell cycle and apoptosis of tested
TNBC cell lines. Our study reveals that TQ can synergise 5-FU action, and increase its anticancer efficiency against
TNBC cells, which might be good choice in drug development for TNBC treatment.
ConA-Coated Liposomes as a System to Delivery β-Lapachone to Breast Cancer Cells
Authors: Magalhães Nereide Stela Santos , Lira-Nogueira Mariane , Franca Larissa , Ferraz Milena , Barros Maria Clara , Gibson Victor , Xavier-Júnior Francisco Humberto 
Published: June 2021

Background:
Target treatment using site-specific nanosystems is a hot topic for treating several diseases,
especially cancer.

Objective:
The study was set out to develop site-specific liposomes using ConcanavalinA (ConA) to target β-
lapachone(β-lap) to human breast cancer cells.

Methods:
Liposomes were prepared and characterized according to diameter size, zeta potential, ConA conjugation(%)
and β-lap encapsulation efficiency (%). Isothermal Titration Calorimetry evaluated the binding energy between the
biomolecules, which compose of the liposomes. ConA avidity was assessed before and after conjugation. Cytotoxicity
was evaluated, and fluorescence microscopy was performed to investigate the influence of ConA influenced on MCF-7
uptake.

Results:
Uncoated and ConA-coated liposomes presented size, and zeta potential values from 97.46 ± 2.01 to 152.23 ±
2.73 nm, and -6.83 ± 0.28 to -17.23 ±0.64 mV, respectively. Both ConA conjugation and β-lap encapsulation efficiency
were approximately 100%. The favorable and spontaneous process confirmed the binding between ConA and the
lipid. Hemagglutination assay confirmed ConA avidity once Lipo-ConA and Lipo-PEG-ConA were able to hemagglutinate
the red blood cells at 128-1 and 256-1, respectively. Lipo-ConA was not cytotoxic, and the site-specific liposomes
presented the highest toxicity. ConA-coated liposomes were more internalized by MCF7 than uncoated-liposomes.

Conclusion:
Therefore, the presence of ConA on the surface of liposomes influenced MCF7 uptake, in that way could
be used as a promising site-specific system to target β-lap to cancer cells.
In Vitro and In Silico Determination of Some N-ferrocenylmethylaniline Derivatives as Anti-Proliferative Agents Against MCF-7 Human Breast Cancer Cell Lines
Authors: Zegheb Nadjiba , Boubekri Cherifa , Lanez Touhami , Lanez Elhafnaoui , Küçükkılınç Tuba Tüylü , Öz Esin , Khennoufa Ali , Khamouli Saida , Belaidi Salah 
Published: June 2021

Background:
Since the binding of estradiol to its receptor promotes breast cancer cell proliferation (in the
ER+ tumours), many molecules targeting this protein have been synthesized to counteract the estradiol action. Ferrocene
derivatives have proved their efficiency against hormone-dependent breast cancer cells (MCF-7).

Objective:
In this study, we aimed to find new ferrocene derivatives having pharmacochemistry properties as potential
drugs against human breast cancer cells.

Methods:
A series of 29 N-ferrocenylmethylaniline derivatives A0-A28 were synthesised, and their anti-proliferative
activity against both hormone-dependent (MCF-7) and independent (MDA-MB 231) human breast cancer cell lines
were performed using the MTT test. Molecular docking and drug-likeness prediction were also performed for the five
most active derivatives towards MCF-7. A QSAR model was also developed for the perdition of the anti-proliferative
activity against MCF-7 cell lines using molecular descriptors and MLR analysis.

Results:
All studied derivatives demonstrated better cytotoxicity against MCF-7 compared to the MDA-MB-231 cell
lines, and compounds A2, A9, A14, A17 and A27 were the most potent ones but still less active than the standard anticancer
drug, crizotinib. The QSAR study revealed good predictive ability, as shown by R2
cv = 0.848.

Conclusion:
In vitro and in silico results indicated that derivatives A2, A9, A14, A17, and A27 possess the highest
anti-proliferative activity; these results can be used to design more potent N-ferrocenylmethylaniline derivatives as
anti-proliferative agents.
Analysis of Contributing Factors Enhancing Rural Transportation System: A Case Study of South-Eastern Provinces of Vietnam
Authors: Hai Dinh Tuan , Quyet Nguyen Xuan 
Published: June 2021

Background:Under-developed countries like Vietnam are facing sustainability problems in developing transportation infrastructure for rural and remote areas. The lack of financial resources and public support is the causative factor of the problem. Rural community participation is considered crucial to resolving these problems. Even demographics strongly influenced, but how they should interact with community participation is still under study in the South-eastern provinces of Vietnam.Methods:South-eastern provinces of Vietnam, including HoChiMinh City and BaRia-VungTau, BinhDuong, BinhPhuoc, DongNai and TayNinh provinces, were selected for the study due to the high requirement of rural transportation infrastructure in these provinces. Questionnaires were sent to local households for data collection. Data analysis was conducted descriptively with the model of logistic regression.Results:Community participation is identified as contributions in terms of finance, labor, material, and land. Household composition, education, income, and a member in the household as a community leader are among the chief contributing factors to community participation.Conclusion:The study can be beneficial for policymakers and local governors in planning and predicting local rural development programs. It aims to enhance rural community participation and increase rural transportation infrastructure in the South-eastern provinces of Vietnam.
Digital Community Inclusion of Individuals With Serious Mental Illness: A National Survey to Map Digital Technology Use and Community Participation Patterns in the Digital Era
Authors: Shpigelman Carmit Noa , Tal Amir , Zisman-Ilani Yaara 
Published: June 2021

Background
Despite the growing interest in developing and using mobile health (mHealth) and digital technologies in mental health, little is known about the scope and nature of virtual community inclusion.

Objective
The overarching goal of this study was to understand and conceptualize virtual community inclusion of individuals with serious mental illness (SMI). Specific objectives of this study were as follows: (1) mapping the prevalence, trends, and experiences related to mHealth and digital technology use among individuals with SMI; (2) comparing patterns of technology use by individuals with and those without SMI; and (3) examining whether use of mHealth and digital technologies predicts recovery among individuals with SMI.

Methods
A web-based survey of technology use and virtual participation was developed and distributed among adults with and those without SMI via social media, national email discussion lists, nonprofit organizations, and advocacy groups.

Results
A total of 381 adults aged 18 years or older participated in the survey, of whom 199 (52%) identified as having a SMI. Participants with SMI reported significantly greater access to technology and significantly fewer days of face-to-face participation in community activities than those without SMI. Among participants with SMI, greater technology use was positively associated with positive emotions and significantly predicted recovery.

Conclusions
This study is the first to explore, map, and conceptualize virtual community inclusion among adults with SMI. Our findings indicate a gap in the literature and research on community inclusion and participation, and emphasize the need for virtual community inclusion, particularly during the COVID-19 pandemic and its future implications.
«¿Mírasme? pues mírote»: mirada y subjetividad en algunas adivinanzas populares medievales
Authors: Cervantes-Espinosa Rodrigo 
Published: June 2021

In recent decades, the critics who have been concerned with the interpretation of the riddles of medieval Hispanic popular lyric have adopted critical approaches oriented towards psychology and pedagogy, without taking into account the stylistic features they present due to their belonging to a specific lyric tradition. Nor have they paid much attention to the analysis of the lyrical subject and its poetic implications. Through the interpretation, from an informed stylistic analysis, some popular riddles fundamental characteristics of subjectivity are evaluated in this lyric form whose main feature is a poetics of dissimulation and obscurity based on the symbolism of the gaze.
Presentación
Authors: Editorial Coordinación 
Published: June 2021

FIGURAS REVISTA ACADÉMICA DE INVESTIGACIÓN sets and builds up –through an act of writing- the act of transforming, tracing or representing in each publication the findings that authors lay on each of the three sections covered in this publication.
In this issue, the Perspectives section includes four articles, two of which are based on the analysis of the phenomenon of racism. One focuses on the racist processes of the Spanish colonial system in the territories of America, and the second takes this reflection towards the questioning of current public policies on public education in the indigenous Ralámuli communities of Sierra Tarahumara, located in northern Mexico. From another field of knowledge, the other two articles -situated in a context prior to modernity- focus on the semiotic content that allows us to approach the Judeo-Spanish mortuary practices, and the other invites us to rethink the riddles of Hispanic medieval popular poetry, beyond the traditional didactic and ludic approaches with which the subject has been treated.
In the section Scenarios, four essays are grouped together which, on this ocassion, have as their axis of reflection the conceptualization of the essay itself. Four looks at the meaning and the sense of the essay as a way of fixing ideas as a manifestation of free thought, as a means to express criticism, as a genre of writing that adapts to a unique writer, or essay writing as a process of self-knowledge.
The Resonances section includes two critiques of recently published books: one addresses the urban development in the city of Mexicali, Baja California, Mexico, highlighting the role of prostitution as a trigger for the urbanization of a border city, and the second -in a compilation of 35 articles-, emphazises the multidisciplinary view of Covid-19 in the context of global governance in the 21st century. Two reviews that encompasses Innovation Projects: one devotes its efforts to the critical decolonial analysis of the practices of the digital Biodiversity Heritage Library (BHL) and proposes a change based on the decolonization of the digital media with which this Library works. In the second, the creation of elaboraHD is reviewed within the framework of the implementation of Digital Humanities that incorporate current technological innovation in the wide field of knowledge that, at the beginning, was not identified with these processes. Finally, within the field of plastic arts, an inspiring review of the pictorial work of an artist whose work is nourished by the political history and the art history of the 20th century.
FIGURAS REVISTA ACADÉMICA DE INVESTIGACIÓN provides free and immediate access to its contents so that research articles, essays and reviews are available, free of charge in order to join the promotion that the Universidad Nacional Autónoma de México is giving to the exchange of research content carried out in the country, through Open Access (OA) template, understood as a way of sharing scientific information at no cost or restriction for the user and in which each article, essay or review appears in a unique way.
Love wave in porous layer under initial stress over heterogeneous elastic half-space under gravity and initial stress
Authors: Gupta Asit Kumar , Mukhopadhyay Anup Kumar , Kundu Santimoy , Patra Pulak 
Published: June 2021

In the present paper, effect of initial stresses and gravity on the propagation of Love waves has been studied in porous layer surface over a heterogeneous half-space. We have considered two types of boundary on free surfaces: (a) rigid boundary and (b) traction free boundary. The propagation of Love waves has been investigated under assumed media in both the cases of boundary and discusses a comparison study of two cases. The dispersion equations and phase velocities have been obtained in both the cases. The numerical calculations have been done and presented graphically. This study of Love waves in the assumed medium reveals that the presence of initial stress in the half-space and absence of initial stress in the layer, the displacement of phase velocity in rigid boundary is more than the traction free boundary.