bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of honey authenticity in Lebanon by analysis of carbon stable isotope ratio using elemental analyzer and liquid chromatography coupled to isotope ratio mass spectrometry
Authors: El Hawari Khaled , Al Iskandarani Mohamad , Jaber Farouk , Ezzeddine Raed , Ziller Luca , Perini Matteo , Bontempo Luana , Pellegrini Maura , Camin Federica 
Published: April 2021

AbstractHoney is one of the most valuable sweeteners consumed by humans all over the world. Consequently, it is often a target for adulteration through the addition of different sugar syrups during or after honey production, resulting in a reduction in its nutritive value. For the first time, this study analyzes honey samples of various botanical species collected from different Lebanese regions using element analyzer (EA) and liquid chromatography (LC) coupled with isotope ratio mass spectrometry (IRMS). The δ13C of bulk honey, its protein fraction, and the main individual sugars (glucose, fructose, disaccharides, and trisaccharide) were determined, in order to characterize and evaluate the authenticity of honey consumed in Lebanon. The results showed that the δ13C values for bulk honey and its protein range from −26.5‰ to −24.5‰ and from −26.4‰ to −24.7‰, respectively, for authentic samples. δ13C values for samples adulterated with sugar syrups range from −11.2‰ to −25.1‰ for bulk honey and from −26.6‰ to −23.7‰ for its proteins, with a difference between bulk and protein values between −1 and −8.7‰. Using LC‐C‐IRMS techniques, the δ13C of individual sugars provides additional information on the presence of undeclared sugars. We found that all authentic samples had Δδ13Cf‐g and Δδ13C max values within the naturally occurring range of ±1‰ and ±2.1‰, respectively, while the adulterated samples fall outside the Δδ13C ranges. The oligosaccharide peak was detected in most adulterated samples.
Bioinformatics and immunoinformatics to support COVID‐19 vaccine development
Authors: Ishack Stephanie , Lipner Shari R. 
Published: April 2021

AbstractSevere acute respiratory syndrome coronavirus 2 has infected over 109 000 000 people with 2 423 443 deaths as of February 17, 2021. Currently, there are no approved or consistently effective treatments, and conventional vaccines may take several years for development and testing. In silico methods of bioinformatics, vaccinogenomics, immunoinformatics, structural biology, and molecular simulations can be used for more rapid and precise vaccine design. This paper highlights two major immunoinformatics strategies that are used in designing novel and effective vaccines and therapeutics: reverse vaccinology and structural vaccinology.
Synergistic corrosion inhibition of A3steel in hydrochloric acid by Sodium dodecyl sulfate and 2‐mercaptopyridine: Experimental and theoretical calculations
Authors: Han Peng , Du Fei , Wang Xiuzhi , Xu Chenyang , Liu Ruiping , Shi Liqing , Song Liying , Zhang Junqing , Zhang Lei , He Yang 
Published: April 2021

AbstractThe inhibition performance of sodium dodecyl sulfate (SDS) and 2‐mercaptopyridine (2MP) corrosion inhibitors on A3steel in 0.5 M HCl increase with increasing of the inhibitor concentration (50–200 mg L−1). SDS and 2MP inhibitor follow Freundlich adsorption isotherm and Langmuir adsorption isotherm, respectively. These two inhibitors exhibit good synergistic inhibition effect on the corrosion of A3steel in 0.5 M HCl solution when the mass ratio of SDS:2MP is 1:4. Gibbs free energy of the mixture is lower and the mixture exhibit good adsorption stability. 2MP molecule are adsorbed on metal surface through N atom and sulfhydryl group. SDS molecule interacts with metal through O atoms while the alkyl chain pointing to the test solution. This adsorption configuration is beneficial to the formation of the inhibitor film, the migration of the corrosive particles to the metal surface was hindered and thus the metal surface was protected.
Joining of plastic‐metal hybrid components by overmoulding of specially designed form‐closure elements
Authors: Wurzbacher S. , Gach S. , Reisgen U. , Hopmann C. 
Published: April 2021

AbstractEcological and economic aspects nowadays increasingly require the development of weight‐reduced designs and energy‐efficient production processes. Particularly in the field of modern vehicle or aircraft construction, developers endeavour to take into account the ever more extensive customer requirements for safety and comfort by using lightweight construction. In many lightweight construction applications, alongside the classic material steel, plastics and the light metals aluminium, magnesium and titanium are being used. Due to a wide variety of requirements, the combination of different material classes to form hybrids will become even more important in the future. Injection moulding is an established method to join plastic‐metal hybrid components. In the present study, the potentials of electron beam structuring by means of surfi‐sculpt, an electron beam material processing technology, on different lightweight materials for the generation of form‐fit elements in plastic‐metal‐hybrid components to be used to join both materials by overmoulding are analysed. The analysis is performed by means of tensile shear test specimens.
Design, Synthesis and Biological Evaluation of Tetrahydrodibenzo[b,g][1,8]napthyridinones as Potential Anticancer Agents and Novel Aurora Kinases Inhibitors
Authors: Chate Asha V. , Tagad Pramod A. , Bondle Giribala M. , Sarkate Aniket P. , Tiwari Shailee V. , Azad Rajaram 
Published: April 2021

AbstractAurora kinases inhibitors A and B have elucidated a vital role within the carcinogenesis and metastases of assorted sort of cancer. Variety of novel methodologies of drug style and support of potential enzyme inhibitors square measure listed in clinical trials, probably there‘s no advanced clinical role for kinases because the key targets for developing drug than in cancer medical care until date. Therefore, we have designed and synthesized novel tetrahydrodibenzo[b,g] [1,8]naphthyridinone molecules victimisation L‐Proline in ethanol as associate adept organocatalyst for one‐pot synthesis. This methodology is delicate, competent, high yielding, and also the product was directly crystallized from hot ethanol, in addition to this synthesized compounds were biologically evaluated for anticancer activity against human respiratory organ cancer (A549), human hepatocellular liver cancer (HepG2) and human cervical cancer animal tissue (HeLa) cells victimisation MTT assay victimisation VX‐680 as normal drug, specifically inhibiting Aurora A and Aurora B kinases. The compounds 4 f,4 h and 4k were found to be sensible anticancer agents against the complete selected cancer cell lines. The compound 4k was found to be the foremost potent anticancer compound among the synthesized derivatives with IC50 value 16.22 μM, 20.14 μM and 5.32 μM against A549, HepG2 and Hela cell lines. The potent compounds 4 f,4 h and 4k were specifically inhibiting Aurora A and Aurora B kinases. The compound 4k was found to be potent Aurora kinases substance with IC50 value 24 nM and 58 nM against Aurora A and Aurora B, respectively. The results of Aurora enzymes restrictive activities recommend that the synthesized compounds exert their anticancer activity by inhibiting aurora kinase inhibitors.
Multi‐Functional Cerium Modification to Accelerate the Oxygen Reduction Reaction of Spinel Co3O4
Authors: Wang Lemiao , Liu Qianfeng , Ta Na , Fan Hefei , Wang Erdong 
Published: April 2021

AbstractTo enhance the oxygen reduction reaction (ORR) activity of spinel Co3O4, in this work, a novel strategy of cerium (Ce) modification is developed via the co‐precipitation and followed annealing method. The Ce modification not only diminishes the critical size, but also increases the surface content of Co3+ and elevates the conductivity of the Co3O4 electrocatalysts, working together to enhance the ORR activity. Moreover, the adsorptive CeO2 on the surface of Co3O4 further promotes the ORR activity by the synergistic effect between CeO2 and Co3O4. Typically, the optimized 0.5 % Ce−Co3O4 exhibits a half‐wave potential of 0.665 V versus reversible hydrogen electrode (RHE) and low Tafel slope of −60 mV dec−1 as well as long‐term stability.
Nanotheranostics for the Management of Hepatic Ischemia‐Reperfusion Injury
Authors: Guan Yu , Yao Weifeng , Yi Ke , Zheng Chunxiong , Lv Shixian , Tao Yu , Hei Ziqing , Li Mingqiang 
Published: April 2021

AbstractHepatic ischemia‐reperfusion injury (IRI), in which an insufficient oxygen supply followed by reperfusion leads to an inflammatory network and oxidative stress in disease tissue to cause cell death, always occurs after liver transplantations and sections. Although pharmacological treatments favorably prevent or protect the liver against experimental IRI, there have been few successes in clinical applications for patient benefits because of the incomprehension of complicated IRI‐induced signaling events as well as short blood circulation time, poor solubility, and severe side reactions of most antioxidants and anti‐inflammatory drugs. Nanomaterials can achieve targeted delivery and controllable release of contrast agents and therapeutic drugs in desired hepatic IRI regions for enhanced imaging sensitivity and improved therapeutic effects, emerging as novel alternative approaches for hepatic IRI diagnosis and therapy. In this review, the application of nanotechnology is summarized in the management of hepatic IRI, including nanomaterial‐assisted hepatic IRI diagnosis, nanoparticulate systems‐mediated remission of reactive oxygen species‐induced tissue injury, and nanoparticle‐based targeted drug delivery systems for the alleviation of IRI‐related inflammation. The current challenges and future perspectives of these nanoenabled strategies for hepatic IRI treatment are also discussed.
Precision SMEFT bounds from the VBF Higgs at high transverse momentum
Authors: Araz Jack Y. , Banerjee Shankha , Gupta Rick S. , Spannowsky Michael 
Published: April 2021

Abstract
We study the production of Higgs bosons at high transverse momenta via vector-boson fusion (VBF) in the Standard Model Effective Field Theory (SMEFT). We find that contributions from four independent operator combinations dominate in this limit. These are the same ‘high energy primaries’ that control high energy diboson processes, including Higgs-strahlung. We perform detailed collider simulations for the diphoton decay mode of the Higgs boson as well as the three final states arising from the ditau channel. Using the quadratic growth of the SMEFT contributions relative to the Standard Model (SM) contribution, we project very stringent bounds on these operators that far surpass the corresponding bounds from the LEP experiment.
Comments on the quantum field theory of the Coulomb gas formalism
Authors: Kapec Daniel , Mahajan Raghu 
Published: April 2021

Abstract
The holomorphic Coulomb gas formalism, as developed by Feigin-Fuchs, Dotsenko-Fateev and Felder, is a set of rules for computing minimal model observables using free field techniques. We attempt to derive and clarify these rules using standard techniques of quantum field theory. We begin with a careful examination of the timelike linear dilaton. Although the background charge of the model breaks the scalar field’s continuous shift symmetry, the exponential of the action remains invariant under a discrete shift because the background charge is imaginary. Gauging this symmetry makes the dilaton compact and introduces winding modes into the spectrum. One of these winding operators corresponds to the anti-holomorphic completion of the BRST current first introduced by Felder, and the full left/right cohomology of this BRST charge isolates the irreducible representations of the Virasoro algebra within the degenerate Fock space of the linear dilaton. The “supertrace” in the BRST complex reproduces the minimal model partition function and exhibits delicate cancellations between states with both momentum and winding. The model at the radius $$ R=\sqrt{pp^{\prime }} $$
R
=

pp
′

has two marginal operators corresponding to the Dotsenko-Fateev “screening charges”. Deforming by them, we obtain a model that might be called a “BRST quotiented compact timelike Liouville theory”. The Hamiltonian of the zero-mode quantum mechanics of this model is not Hermitian, but it is PT-symmetric and exactly solvable. Its eigenfunctions have support on an infinite number of plane waves, suggesting an infinite reduction in the number of independent states in the full quantum field theory. Applying conformal perturbation theory to the exponential interactions reproduces the Coulomb gas calculations of minimal model correlation functions. In contrast to spacelike Liouville, these “resonance correlators” are finite because the zero mode is compact. We comment on subtleties regarding the reflection operator identification, as well as naive violations of truncation in correlators with multiple reflection operators inserted. This work is part of an attempt to understand the relationship between the JT model of two dimen- sional gravity and the worldsheet description of the (2, p) minimal string as suggested by Seiberg and Stanford.
Evaluating EYM amplitudes in four dimensions by refined graphic expansion
Authors: Tian Hongxiang , Gong Enze , Xie Chongsi , Du Yi-Jian 
Published: April 2021

Abstract
The recursive expansion of tree level multitrace Einstein-Yang-Mills (EYM) amplitudes induces a refined graphic expansion, by which any tree-level EYM amplitude can be expressed as a summation over all possible refined graphs. Each graph contributes a unique coefficient as well as a proper combination of color-ordered Yang-Mills (YM) amplitudes. This expansion allows one to evaluate EYM amplitudes through YM amplitudes, the latter have much simpler structures in four dimensions than the former. In this paper, we classify the refined graphs for the expansion of EYM amplitudes into N k MHV sectors. Amplitudes in four dimensions, which involve k + 2 negative-helicity particles, at most get non-vanishing contribution from graphs in N k′ (k′ ≤ k) MHV sectors. By the help of this classification, we evaluate the non-vanishing amplitudes with two negative-helicity particles in four dimensions. We establish a correspondence between the refined graphs for single-trace amplitudes with $$ \left({g}_i^{-},{g}_j^{-}\right) $$

g
i
−

g
j
−

or $$ \left({h}_i^{-},{g}_j^{-}\right) $$

h
i
−

g
j
−

configuration and the spanning forests of the known Hodges determinant form. Inspired by this correspondence, we further propose a symmetric formula of double-trace amplitudes with $$ \left({g}_i^{-},{g}_j^{-}\right) $$

g
i
−

g
j
−

configuration. By analyzing the cancellation between refined graphs in four dimensions, we prove that any other tree amplitude with two negative-helicity particles has to vanish.
Maritime vessel re-identification: novel VR-VCA dataset and a multi-branch architecture MVR-net
Authors: Ghahremani Amir , Alkanat Tunc , Bondarev Egor , de With Peter H. N. 
Published: April 2021

AbstractMaritime vessel re-identification (re-ID) is a computer vision task of vessel identity matching across disjoint camera views. Prominent applications of vessel re-ID exist in the fields of surveillance and maritime traffic flow analysis. However, the field suffers from the absence of a large-scale dataset that enables training of deep learning models. In this study, we present a new dataset that includes 4614 images of 729 vessels along with 5-bin orientation and 8-class vessel-type annotations to promote further research. A second contribution of this study is the baseline re-ID analysis of our new dataset. Performances of 10 recent deep learning architectures are quantitatively compared to reveal the best practices. Lastly, we propose a novel multi-branch deep learning architecture, Maritime Vessel Re-ID network (MVR-net), to address the challenging problem of vessel re-ID. Evaluation of our approach on the new dataset yields 74.5% mAP and 77.9% Rank-1 score, providing a performance increase of 5.7% mAP and 5.0% Rank-1 over the best-performing baseline. MVR-net also outperforms the PRN (a pioneering vehicle re-ID network), by 2.9% and 4.3% higher mAP and Rank-1, respectively.
Digitalisierung und Organisationsethik. Ethische und technikphilosophische Skizzen
Authors: Manzeschke Arne 
Published: April 2021

ZusammenfassungOrganisationen sind wichtige Intermediäre in modernen ausdifferenzierten und pluralen Gesellschaften. In ihnen und durch sie werden ein Großteil der Entscheidungen verfertigt. Das betrifft nicht zuletzt Organisationen des Gesundheitssektors. Durch Digitalisierung und Vernetzung werden solche organisationalen Prozesse erneut und in erheblichem Maße herausgefordert, was auch die Organisationsethik zu Rekonzeptualisierungen zwingt. Der Artikel skizziert einige Grundprobleme einer der Digitalisierung angemessenen Organisationsethik.
Assessing the potential of online ICP–MS analysis to optimize Ca/matrix separation using DGA Resin for subsequent isotopic analysis
Authors: Retzmann Anika , Walls Dorothy , Miller Kerri , Wieser Michael , Irrgeher Johanna , Prohaska Thomas 
Published: April 2021

AbstractCa isotopes have gained increasing interest as a diagnostic tool for bone diseases due to the variations in abundances as a consequence of changes in bone-mineral balance. Optimized Ca/matrix separation prior to analysis is a prerequisite for reliable isotope ratio measurements in complex biological matrices such as blood, serum, or urine. The online analysis of analyte/matrix separation by ICP-MS enables direct assessment of elution profiles supporting the optimization process. The integration of transient signals and signal suppression challenge the quantification and interpretation of the elution profiles. Mn and Co remain unretained by the DGA Resin (TrisKem International) from nitric acid. Hence, in the present study, these elements were investigated for their application as standards to monitor signal suppression. Successful analyte quantification was accomplished using a dynamic correction strategy applying a linear gradient of a suppression factor based on Mn and Co intensities. An optimized Ca/matrix separation procedure using DGA Resin is proposed based on the results during online ICP-MS analysis.
Graphic abstract
A device for rainfall simulation in geotechnical centrifuges
Authors: Wang Shun , Idinger Gregor 
Published: April 2021

AbstractRainfall-induced slope instabilities are ubiquitous in nature, but simulation of this type of hazards with centrifuge modelling still poses difficulties. In this paper, we introduce a rainfall device for initiating slope failure in a medium-sized centrifuge. This rainfall system is simple, robust and affordable. An array of perforated hoses is placed close above the model slope surface to generate the raindrops. The rainfall intensity depends on the centrifuge acceleration and the flow rate of the water supply, which is controlled by the size and number of the tiny pinholes in the hose walls. The rainfall intensities that are tested range from 2.5–30 mm/h, covering the intensity range of moderate, heavy and torrential rainfall events. Our model test with rainfall-induced slope failure shows that this system is capable of generating relatively uniform rainfall of wide intensities and leads to various patterns of slope failure.
Long-Term Non-progression in Metastatic Breast Cancer Beyond 5 Years: Case Series and Review
Authors: Sytov Alexander , Brenin Christiana , Millard Trish , Showalter Shayna , Dillon Patrick 
Published: April 2021

Abstract
Purpose of review
Metastatic breast cancer (MBC) was traditionally viewed as homogeneously progressive and incurable among all comers, but there is new evidence that MBC harbors a range of tumor molecular/immune subtypes and degrees of aggressiveness. Thus, MBC is not rapidly fatal in all affected patients.

Recent findings
A small subset of patients will attain long-term disease control, or undetectable disease, and will enjoy a prolonged survival with little disability from their disease or treatment. Though the term is controversial, some patients with long-term non-detectable disease may effectively be considered “cured”. To best advise treatment options in these patients, it is imperative to identify patients most likely to benefit from aggressive treatment.

Summary
In this review, we delineate the clinical, pathologic, and disease characteristics associated with long-term non-progression in MBC. We include a single institution case series of long-term non-progressive MBC patients and their characteristics as an example of the frequency of this sub-population of MBC. Future prospective trials are warranted to examine the utility of clinical characteristics as predictors of long-term survival in MBC.
Tracking eye-gaze in smart home systems (SHS): first insights from eye-tracking and self-report measures
Authors: Cassioli Federico , Angioletti Laura , Balconi Michela 
Published: April 2021

AbstractHuman–computer interaction (HCI) is particularly interesting because full-immersive technology may be approached differently by users, depending on the complexity of the interaction, users’ personality traits, and their motivational systems inclination. Therefore, this study investigated the relationship between psychological factors and attention towards specific tech-interactions in a smart home system (SHS). The relation between personal psychological traits and eye-tracking metrics is investigated through self-report measures [locus of control (LoC), user experience (UX), behavioral inhibition system (BIS) and behavioral activation system (BAS)] and a wearable and wireless near-infrared illumination based eye-tracking system applied to an Italian sample (n = 19). Participants were asked to activate and interact with five different tech-interaction areas with different levels of complexity (entrance, kitchen, living room, bathroom, and bedroom) in a smart home system (SHS), while their eye-gaze behavior was recorded. Data showed significant differences between a simpler interaction (entrance) and a more complex one (living room), in terms of number of fixation. Moreover, slower time to first fixation in a multifaceted interaction (bathroom), compared to simpler ones (kitchen and living room) was found. Additionally, in two interaction conditions (living room and bathroom), negative correlations were found between external LoC and fixation count, and between BAS reward responsiveness scores and fixation duration. Findings led to the identification of a two-way process, where both the complexity of the tech-interaction and subjects’ personality traits are important impacting factors on the user’s visual exploration behavior. This research contributes to understand the user responsiveness adding first insights that may help to create more human-centered technology.