bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges in simulating economic effects of climate change on global agricultural markets
Authors: Gurgel Angelo C. , Reilly John , Blanc Elodie 
Published: June 2021

AbstractMany approaches have been used to investigate climate change impacts on agriculture. However, several caveats remain in this field: (i) analyses focus only on a few major crops, (ii) large differences in yield impacts are observed between projections from site-based crops models and Global Gridded Crop Models (GGCMs), (iii) climate change impacts on livestock are rarely quantified, and (iv) several causal relations among biophysical, environmental, and socioeconomic aspects are usually not taken into account. We investigate how assumptions about these four aspects affect agricultural markets, food supply, consumer well-being, and land use at global level by deploying a large-scale socioeconomic model of the global economy with detailed representation of the agricultural sector. We find global welfare impacts several times larger when climate impacts all crops and all livestock compared to a scenario with impacts limited to major crops. At the regional level, food budget can decrease by 10 to 25% in developing countries, challenging food security. The role of land area expansion as a major source of adaptation is highlighted. Climate impacts on crop yields from site-based process crop models generate more challenging socioeconomic outcomes than those from GGCMs. We conclude that the agricultural research community should expand efforts to estimate climate impacts on many more crops and livestock. Also, careful comparison of the GGCMs and traditional site-based process crop models is needed to understand their major implications for agricultural and food markets.
Changes in energetic metabolism and lysosomal destruction in the skeletal muscle and cardiac tissues of pigeons (Columba livia f. urbana) from urban areas of the northern Pomeranian region (Poland)
Authors: Tkachenko Halyna , Kurhaluk Natalia , Hetmański Tomasz , Włodarkiewicz Agnieszka , Tomin Vladimir 
Published: June 2021

AbstractThe aim of the present study was to evaluate the biochemical responses of the skeletal muscle and cardiac tissues of the urban pigeon as a bioindicator organism tested in diverse environments (Szpęgawa as a rural environment and Słupsk as an urban environment, Pomeranian Voivodeship, northern Poland), resulting in changes in the level of lipid peroxidation at the initial and final stages of this process and the activities of Krebs cycle enzymes (succinate dehydrogenase, pyruvate dehydrogenase, isocitrate dehydrogenase, and alfa-ketoglutarate dehydrogenase). Szpęgawa village was chosen due to the intensive use of the European motorway A1 with significant traffic and pollution levels. The concentration of Pb was higher in the soil and feathers of pigeons nesting in the polluted areas (Szpęgawa). Our studies have shown that the presence of lead in soil and feathers of the pigeons resulted in the activation of lipid peroxidation, destabilization and increased activity of lysosomal membranes, and activation of mitochondrial enzymes of the Krebs cycle with energy deficiency (reduction of ATP levels) in cardiac and skeletal muscle tissues simultaneously.
The morendo of the Anthropocene
Authors: Blok Vincent 
Published: June 2021

AbstractThis essay engages with Bernard Stiegler’s discussion with Martin Heidegger in The ordeal of Truth, published in Foundations of Science 2020 (this volume). It appreciates Stiegler’s progressive reading of Heidegger’s work but critically reflects on several elements in his work. A first element is the methodological aspect of Heidegger’s being historical thinking, which is missed by Stiegler and confirms the indifference towards philosophical method that can be found in the work of many contemporary philosophers. A second element concerns Heidegger’s and Stiegler’s remaining humanism and the necessity to move beyond humanism and post-humanism in the era of global warming. A third element of reflection concerns Stiegler’s idea of the obligation of making our being-in-default come true, which shows a hidden metaphysical orientation in his work.
“If I won the lottery…”: work orientations of low-qualified young adults in Albania and Switzerland
Authors: Kallciu Nada , Zhilla Eralda , Fedrigo Laurence , Nano Livia , Masdonati Jonas 
Published: June 2021

AbstractA qualitative study was carried out to portray the work orientations of 30 low-qualified working young adults in two contrasted economies: Albania and Switzerland. The analysis of their answers to the “lottery question” showed that most participants would continue to work, either to be busy, feed a passion, feel useful, or grow. In contrast to participants from Switzerland, Albanian participants would more easily modify some aspects of their work. Globally, findings reveal that participants’ current situations tend to differ from what they expect from work, which impacts the quality of their work integration and has critical implications for career counseling.
Technological problem solving: an investigation of differences associated with levels of task success
Authors: Morrison-Love David 
Published: June 2021

AbstractResearch into technological problem solving has shown it to exist in a range of forms and draw upon different processes and knowledge types. This paper adds to this understanding by identifying procedural and epistemic differences in relation to task performance for pupils solving a well-defined technological problem. The study is theoretically grounded in a transformative epistemology of technology education. 50 pupils in small groups worked through a cantilever problem, the most and least successful solutions to which were identified using a Delphi technique. Time-interval photography, verbal interactions, observations and supplementary data formed a composite representation of activity which was analysed with successively less contrasting groups to isolate sustained differences. Analyses revealed key differences in three areas. First, more successful groups used better and more proactive process-management strategies including use of planning, role and task allocation with lower levels of group tension. Second, they made greater use of reflection in which knowledge associated with the technological solution was explicitly verblised. This was defined as ‘analytical reflection’ and reveals aspects of pupils’ qualitative technical knowledge. Third, higher-performing groups exhibited greater levels of tacit-procedural knowledge within their solutions. There was also evidence that less successful groups were less affected by competition and not as comprehensive in translating prior conceptual learning into their tangible technological solutions. Overall findings suggest that proactive management, and making contextual and technical connections, are important for pupils solving well-defined technological problems. This understanding can be used to support classroom pedagogies that help pupils learn to problem solve more effectively.
Disruptive Behavior Disorders and Psychopathic Traits in Adolescents: Empathy-Related Responses to Witnessing Animal Distress
Authors: de Wied Minet , Meeus Wim , van Boxtel Anton 
Published: June 2021

AbstractCruelty to animals is a symptom of conduct disorder and associated with psychopathic traits in childhood. One of the factors thought to contribute to animal cruelty is reduced empathy and concern for the well-being of animals. A first aim of this study was to examine empathy towards animals in distress in male adolescents with disruptive behavior disorders (DBD) and high or low psychopathic traits, and normal controls (NC). Psychopathic traits were assessed by the Antisocial Process Screening Device (APSD). Respondents were exposed to a short film clip depicting a baby bear in distress. Heart rate (HR) responses were monitored during film exposure. Afterwards, respondents were asked to report the emotions they had observed and experienced. Contrary to expectations based on research on human empathy, no group differences were found in empathy-related responses to witnessing animal distress. Both DBD groups and normal controls observed equal levels of distress in the baby bear, experienced as much empathy and sympathy, and showed similar levels of HR reduction during the most dramatic scene. Results suggest that empathy for humans does not generalize to animals, and vice versa. A second aim was to examine the associations between empathy-related responses and the broad concept of psychopathy as well as its dimensions. The relationships were different and for the most part reversed in the NC and DBD groups. Group proved to be an important moderating factor, indicating that results obtained within a sample of healthy adolescents do not generalize to adolescents with DBD, and vice versa.
Kinetic aspects of virus targeting by nanoparticles in vivo
Authors: Zhdanov Vladimir P. 
Published: June 2021

AbstractOne of the suggested ways of the use of nanoparticles in virology implies their association with and subsequent deactivation of virions. The conditions determining the efficiency of this approach in vivo are now not clear. Herein, I propose the first kinetic model describing the corresponding processes and clarifying these conditions. My analysis indicates that nanoparticles can decrease concentration of infected cells by a factor of one order of magnitude, but this decrease itself (without feedback of the immune system) is insufficient for full eradication of infection. It can, however, induce delay in the progress of infection, and this delay can help to form sufficient feedback of the immune system.
Lineage-Specific Chimerism and Outcome After Hematopoietic Stem Cell Transplantation for DOCK8 Deficiency
Authors: Raedler Johannes , Magg Thomas , Rohlfs Meino , Klein Christoph , Vallée Tanja , Hauck Fabian , Albert Michael H. 
Published: June 2021

AbstractBi-allelic variants in the dedicator of cytokinesis 8 (DOCK8) gene cause a combined immunodeficiency, characterized by recurrent sinopulmonary and skin infections, food allergies, eczema, eosinophilia, and elevated IgE. Long-term outcome is poor given susceptibility to infections, malignancy, and vascular complications. Allogeneic hematopoietic stem cell transplantation is currently the only curative treatment option and has shown promising outcome. The impact of mixed chimerism on long-term outcome is unclear. We reasoned that reversal of disease phenotype would depend on cell lineage-specific chimerism. DOCK8 variants were confirmed by Sanger and/or exome sequencing and immunoblot and/or intracellular flow cytometry. Donor chimerism was analyzed by XY-fluorescence in situ hybridization or quantitative short tandem repeat PCR. Outcome was assessed by laboratory tests, lymphocyte subsets, intracellular DOCK8 protein flow cytometry, T-cell proliferation analysis, and multiparameter immunoblot allergy screening. We report on nine patients, four of whom with mixed chimerism, with a median follow-up of 78 months after transplantation. Overall, we report successful transplantation with improvement of susceptibility to infections and allergies, and resolution of eczema in all patients. Immunological outcome in patients with mixed chimerism suggests a selective advantage for wild-type donor T-cells but lower donor B-cell chimerism possibly results in a tendency to hypogammaglobulinemia. No increased infectious and allergic complications were associated with mixed chimerism. Aware of the relatively small cohort size, we could not demonstrate a consistent detrimental effect of mixed chimerism on clinical outcomes. We nevertheless advocate aiming for complete donor chimerism in treating DOCK8 deficiency, but recommend reduced toxicity conditioning.
Low-rank matrix recovery with Ky Fan 2-k-norm
Authors: Doan Xuan Vinh , Vavasis Stephen 
Published: June 2021

AbstractLow-rank matrix recovery problem is difficult due to its non-convex properties and it is usually solved using convex relaxation approaches. In this paper, we formulate the non-convex low-rank matrix recovery problem exactly using novel Ky Fan 2-k-norm-based models. A general difference of convex functions algorithm (DCA) is developed to solve these models. A proximal point algorithm (PPA) framework is proposed to solve sub-problems within the DCA, which allows us to handle large instances. Numerical results show that the proposed models achieve high recoverability rates as compared to the truncated nuclear norm method and the alternating bilinear optimization approach. The results also demonstrate that the proposed DCA with the PPA framework is efficient in handling larger instances.
On a Certain Operator Related to Blackwell’s Markov Chain
Authors: Nieznaj Ernest 
Published: June 2021

AbstractWe present an example of a densely defined, linear operator on the $$l^{1}$$

l
1

space with the property that each basis vector of the standard Schauder basis of $$l^{1}$$

l
1

does not belong to its domain. Our example is based on the construction of a Markov chain with all states instantaneous given by D. Blackwell in 1958. In addition, it turns out that the closure of this operator is the generator of a strongly continuous semigroup of Markov operators associated with Blackwell’s chain.
Asymmetric and chaotic responses of dry friction oscillators with different static and kinetic coefficients of friction
Authors: Csernák Gábor , Licskó Gábor 
Published: June 2021

AbstractThe responses of a simple harmonically excited dry friction oscillator are analysed in the case when the coefficients of static and kinetic coefficients of friction are different. One- and two-parameter bifurcation curves are determined at suitable parameters by continuation method and the largest Lyapunov exponents of the obtained solutions are estimated. It is shown that chaotic solutions can occur in broad parameter domains—even at realistic friction parameters—that are tightly enclosed by well-defined two-parameter bifurcation curves. The performed analysis also reveals that chaotic trajectories are bifurcating from special asymmetric solutions. To check the robustness of the qualitative results, characteristic bifurcation branches of two slightly modified oscillators are also determined: one with a higher harmonic in the excitation, and another one where Coulomb friction is exchanged by a corresponding LuGre friction model. The qualitative agreement of the diagrams supports the validity of the results.
Epistemology without guidance
Authors: Hughes Nick 
Published: June 2021

AbstractEpistemologists often appeal to the idea that a normative theory must provide useful, usable, guidance to argue for one normative epistemology over another. I argue that this is a mistake. Guidance considerations have no role to play in theory choice in epistemology. I show how this has implications for debates about the possibility and scope of epistemic dilemmas, the legitimacy of idealisation in Bayesian epistemology, uniqueness versus permissivism, sharp versus mushy credences, and internalism versus externalism.
Standard set of patient-reported outcomes for personality disorder
Authors: Prevolnik Rupel Valentina , Jagger Beth , Fialho Luz Sousa , Chadderton Lisa-Marie , Gintner Timea , Arntz Anroud , Baltzersen Åse-Line , Blazdell Julia , van Busschbach Jan , Cencelli Marika , Chanen Andrew , Delvaux Charlotte , van Gorp Fieke , Langford Lucie , McKenna Brian , Moran Paul , Pacheco Karla , Sharp Carla , Wang Wei , Wright Karen , Crawford Mike J. 
Published: June 2021

AbstractPurposeThe purpose of the article is to present standard set of outcomes for people with personality disorder (PD), in order to facilitate patient outcome measurement worldwide.MethodsThe International Consortium for Health Outcomes Measurement (ICHOM) gathered a multidisciplinary international working group, consisting of 16 experts, including clinicians, nurses, psychologists, methodologists and patient representatives, to develop a standard set of outcome measures for people with PD. The Delphi method was used to reach consensus on the scope of the set, outcome domains, outcome measures, case-mix variables and time points for measuring outcomes in service users. For each phase, a project team prepared materials based on systematic literature reviews and consultations with experts.ResultsThe working group decided to include PD, as defined by International Classification of Diseases 11th revision (ICD-11). Eleven core outcomes and three optional outcomes across four health domains (mental health, behaviour, functioning and recovery) were defined as those relevant for people with PD. Validated measures for the selected outcomes were selected, some covering more than one outcome. Case-mix variables were aligned to other ICHOM mental health standard sets and consisted of demographic factors and those related to the treatment that people received. The group recommended that most outcomes are measured at baseline and annually.ConclusionThe international minimum standard set of outcomes has the potential to improve clinical decision making through systematic measurement and comparability. This will be key in improving the standard of health care for people with PD across the world.
Studying the Microstructural Effect of Selective Laser Melting and Electropolishing on the Performance of Maraging Steel
Authors: Ahmadkhaniha D. , Möller H. , Zanella C. 
Published: June 2021

AbstractSelective laser melting is one of the additive manufacturing technologies that have been known for building various and complicated shapes. Despite numerous advantages of additive manufacturing technologies, they strongly influence the microstructure and typically show a relatively high surface roughness. In this study, maraging steel was produced by selective laser melting (SLM), and its microstructure, hardness and corrosion behavior before and after heat treatment were studied and compared to traditionally manufactured ones (wrought, forged samples). In addition, the effect of electropolishing on the surface roughness was evaluated. The microstructural study was carried out by scanning electron microscopy equipped with electron backscattered diffraction in three different sections: parallel to the top surface (xy), transverse cross section (xz) and longitudinal cross section (yz). The same characterization was applied to heat-treated samples, austenitized and quenched as well as the aged ones. The results showed that selective laser melting produced a fine grain martensitic structure (in the as-printed condition) with a surface roughness (Ra) of about 10 µm. There was no sign of preferred texture or anisotropy in the microstructure of as-print SLM materials. The SLM microstructure was similar in all 3 sections (xy, xz and yz). Despite finer microstructure, nano-hardness and corrosion behavior of SLM and conventional wrought maraging steel in heat-treated conditions were similar. Aging resulted in the maximum nano-hardness and the minimum corrosion potential values. Precipitation has the main role in both hardness and corrosion behavior. Electropolishing was optimized and reduced the surface roughness (Ra) by 65%.
Growth Differentiation Factor-15 Produces Analgesia by Inhibiting Tetrodotoxin-Resistant Nav1.8 Sodium Channel Activity in Rat Primary Sensory Neurons
Authors: Lin Wei , Zhang Wen-Wen , Lyu Ning , Cao Hong , Xu Wen-Dong , Zhang Yu-Qiu 
Published: June 2021

AbstractGrowth differentiation factor 15 (GDF-15) is a member of the transforming growth factor-β superfamily. It is widely distributed in the central and peripheral nervous systems. Whether and how GDF-15 modulates nociceptive signaling remains unclear. Behaviorally, we found that peripheral GDF-15 significantly elevated nociceptive response thresholds to mechanical and thermal stimuli in naïve and arthritic rats. Electrophysiologically, we demonstrated that GDF-15 decreased the excitability of small-diameter dorsal root ganglia (DRG) neurons. Furthermore, GDF-15 concentration-dependently suppressed tetrodotoxin-resistant sodium channel Nav1.8 currents, and shifted the steady-state inactivation curves of Nav1.8 in a hyperpolarizing direction. GDF-15 also reduced window currents and slowed down the recovery rate of Nav1.8 channels, suggesting that GDF-15 accelerated inactivation and slowed recovery of the channel. Immunohistochemistry results showed that activin receptor-like kinase-2 (ALK2) was widely expressed in DRG medium- and small-diameter neurons, and some of them were Nav1.8-positive. Blockade of ALK2 prevented the GDF-15-induced inhibition of Nav1.8 currents and nociceptive behaviors. Inhibition of PKA and ERK, but not PKC, blocked the inhibitory effect of GDF-15 on Nav1.8 currents. These results suggest a functional link between GDF-15 and Nav1.8 in DRG neurons via ALK2 receptors and PKA associated with MEK/ERK, which mediate the peripheral analgesia of GDF-15.
Photonics of human saliva: potential optical methods for the screening of abnormal health conditions and infections
Authors: Lukose Jijo , M. Sanoop Pavithran , N. Mithun , Barik Ajaya Kumar , Pai Keerthilatha M. , Unnikrishnan V. K. , George Sajan D. , Kartha V. B. , Chidangil Santhosh 
Published: June 2021

AbstractHuman saliva can be treated as a pool of biological markers able to reflect on the state of personal health. Recent years have witnessed an increase in the use of optical devices for the analysis of body fluids. Several groups have carried out studies investigating the potential of saliva as a non-invasive and reliable clinical specimen for use in medical diagnostics. This brief review aims to highlight the optical technologies, mainly surface plasmon resonance (SPR), Raman, and Fourier transform infrared (FTIR) spectroscopy, which are being used for the probing of saliva for diverse biomedical applications. Advances in bio photonics offer the promise of unambiguous, objective and fast detection of abnormal health conditions and viral infections (such as COVID-19) from the analysis of saliva.