bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of Endometrial Cancer and Frequencies of Invasive Endometrial Procedures in Young Breast Cancer Survivors Treated With Tamoxifen: A Nationwide Study
Authors: Choi Soojeong , Lee Young Jae , Jeong Jae Ho , Jung Jinhong , Lee Jong Won , Kim Hee Jeong , Ko Beom Seok , Son Byung Ho , Ahn Sei Hyun , Lee Yura , Chung Il Yong 
Published: June 2021

BackgroundAlthough the guidelines recommend gynecological assessment and close monitoring for symptoms of endometrial cancer in postmenopausal breast cancer survivors taking tamoxifen (TAM), the risk of endometrial cancer in young breast cancer survivors has not yet been fully assessed. This study aimed to investigate the risk of developing endometrial cancer and the frequencies of gynecological examinations in young breast cancer survivors taking TAM in South Korea.MethodsA nationwide retrospective cohort study was conducted using the Health Insurance Review and Assessment Service claims data. Kaplan–Meier analyses and log-rank tests were used to assess the probability of endometrial cancer, benign endometrial conditions, and the probability of invasive endometrial procedure. To analyze the risk of endometrial cancer and benign endometrial conditions, we used a multivariable Cox proportional hazards regression model.ResultsBetween 2010 and 2015, 60,545 newly diagnosed female breast cancer survivors were included. The total person–years were 256,099 and 140 (0.23%) patients developed endometrial cancer during the study period. In breast cancer survivors aged ≥60 years [hazard ratio (HR), 5.037; 95% confidence interval (CI), 2.185–11.613], 50–59 years (HR, 4.343; 95% CI, 2.122–8.891), and 40–49 years (HR, 2.121; 95% CI, 1.068–4.213), TAM was associated with an increased risk of endometrial cancer. In subjects aged below 40 years, TAM did not significantly increase the risk of endometrial cancer. However, among the TAM subgroups, breast cancer survivors aged below 40 years [1.61 per 1,000 person–years (PY); HR, 12.460; 95% CI, 2.698–57.522] and aged 40–49 years (2.22 per 1,000 PY; HR, 9.667; 95% CI, 4.966–18.819) with TAM-related endometrial diseases showed significantly increased risks of endometrial cancer. Among the TAM subgroup with benign endometrial conditions, the ratios of the frequency of invasive diagnostic procedures to the incidence of endometrial cancer were higher in subjects under 40 than subjects aged 60 or more.ConclusionYoung breast cancer survivors with TAM-related benign endometrial diseases are at a higher risk of developing endometrial cancer. Gynecological surveillance should be tailored to the risk of endometrial cancer in young breast cancer survivors to improve the early detection of endometrial cancer and avoid unnecessary invasive procedures.
Chrysin Induced Cell Apoptosis Through H19/let-7a/COPB2 Axis in Gastric Cancer Cells and Inhibited Tumor Growth
Authors: Chen Lin , Li Qirong , Jiang Ziping , Li Chengshun , Hu Haobo , Wang Tiedong , Gao Yan , Wang Dongxu 
Published: June 2021

BackgroundChrysin is a natural flavone that is present in honey and has exhibited anti-tumor properties. It has been widely studied as a therapeutic agent for the treatment of various types of cancers. The objectives of this present study were to elucidate how chrysin regulates non-coding RNA expression to exert anti-tumor effects in gastric cancer cells.MethodsThrough the use of RNA sequencing, we investigated the differential expression of mRNAs in gastric cancer cells treated with chrysin. Furthermore, COPB2, H19 and let-7a overexpression and knockdown were conducted. Other features, including cell growth, apoptosis, migration and invasion, were also analyzed. Knockout of the COPB2 gene was generated using the CRISPR/Cas9 system for tumor growth analysis in vivo.ResultsOur results identified COPB2 as a differentially expressed mRNA that is down-regulated following treatment with chrysin. Moreover, the results showed that chrysin can induce cellular apoptosis and inhibit cell migration and invasion. To further determine the underlying mechanism of COPB2 expression, we investigated the expression of the long non-coding RNA (lncRNA) H19 and microRNA let-7a. Our results showed that treatment with chrysin significantly increased let-7a expression and reduced the expression of H19 and COPB2. In addition, our results demonstrated that reduced expression of COPB2 markedly promotes cell apoptosis. Finally, in vivo data suggested that COPB2 expression is related to tumor growth.ConclusionsThis study suggests that chrysin exhibited anti-tumor effects through a H19/let-7a/COPB2 axis.
A Poliovirus Receptor (CD155)-Related Risk Signature Predicts the Prognosis of Bladder Cancer
Authors: Luo Cong , Ye Wenrui , Hu Jiao , Othmane Belaydi , Li Huihuang , Chen Jinbo , Zu Xiongbing 
Published: June 2021

BackgroundBladder cancer is an aggressive and heterogeneous disease associated with high morbidity and mortality. And poliovirus receptor (PVR or CD155) played crucial roles in tumor immune microenvironment and cancer development. However, their association remains obscure.MethodsA total of 797 patients from TCGA and GEO databases were employed in our study, in which 285 cases were set as the training cohort and 512 were defined as the validation cohort. Our own Xiangya cohort with 57 samples was also used for the validation. Survival differences were evaluated by Kaplan-Meier analysis between groups. The immune infiltration was evaluated by ESTIMATE, TIMER, and CIBERSORT algorithms. The risk signature was constructed by LASSO Cox regression analysis. And a nomogram model was generated subsequent to the multivariate Cox proportional hazards analysis to predict 3- and 5-year survival of patients with bladder cancer.ResultsPVR was overexpressed across various cancers including bladder cancer and related to poorer overall survival in bladder urothelial carcinoma (BLCA). Samples with higher World Health Organization (WHO) grade or higher tumor stage tended to express higher level of PVR. And PVR-related genes were involved in several immune processes and oncological pathways. When the patients were divided into low- and high-risk groups based on their risk scores, we found that patients in the high-risk group had shorter overall survival time. Besides, samples with high risk were consistently correlated with tumor hallmarks and higher abundance of immune infiltration. Additionally, chemotherapy showed potent efficacy in high-risk group. Moreover, a nomogram including clinicopathologic features and the established risk signature could predict 3- and 5-year survival in patients with bladder cancer.ConclusionOur study revealed that PVR was overexpressed and related to poor prognosis in bladder cancer. A risk signature and nomogram model based on PVR-related genes could predict the prognosis and therapeutic efficacy and were also associated with the immune infiltration in bladder cancer.
Clinical Benefits and Safety of FMS-Like Tyrosine Kinase 3 Inhibitors in Various Treatment Stages of Acute Myeloid Leukemia: A Systematic Review, Meta-Analysis, and Network Meta-Analysis
Authors: Xu Qingyu , He Shujiao , Yu Li 
Published: June 2021

BackgroundGiven the controversial roles of FMS-like tyrosine kinase 3 inhibitors (FLT3i) in various treatment stages of acute myeloid leukemia (AML), this study was designed to assess this problem and further explored which FLT3i worked more effectively.MethodsA systematic review, meta-analysis and network meta-analysis (NMA) were conducted by filtering PubMed, Embase, Cochrane library, and Chinese databases. We included studies comparing therapeutic effects between FLT3i and non-FLT3i group in AML, particularly FLT3(+) patients, or demonstrating the efficiency of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in FLT3(+) AML. Relative risk (RR) with 95% confidence intervals (CI) was used for estimating complete remission (CR), early death and toxicity. Hazard ratio (HR) was used to assess overall survival (OS), event-free survival (EFS), relapse-free survival (RFS) and cumulative incidence of relapse (CIR).ResultsAfter addressing all criteria, 39 studies were eventually analyzed. Better CR was accomplished by FLT3i in untreated AML (RR 0.88, p = 0.04) and refractory and relapsed FLT3(+) AML (rrAML) (RR 0.61, p &lt; 0.01) compared to non-FLT3i arm, followed by improved survival (untreated AML: OS, HR 0.76; EFS, HR 0.67; RFS, HR 0.72; all p &lt; 0.01; FLT3(+) rrAML: OS, HR 0.60, p &lt; 0.01; RFS, HR 0.40, p = 0.01). In addition, allo-HSCT improved survival in FLT3(+) AML (OS, HR 0.53; EFS, HR 0.50; RFS, HR 0.57; CIR, HR 0.26; all p &lt; 0.01), which was further prolonged by FLT3i administrated after allo-HSCT (OS, HR 0.45; RFS, HR 0.34; CIR, HR 0.32; all p &lt; 0.01). Additionally, FLT3i consistently improved OS (p &lt; 0.05) regardless of FLT3-ITD ratio, when compared to non-FLT3i group. Besides, FLT3i showed significantly increased risk of thrombocytopenia, neutropenia, anemia, skin- and cardiac-related adverse effects, increased alanine aminotransferase, and increased risk of cough and dyspnea (p &lt; 0.05). In NMA, gilteritinib showed the highest probability for improved prognosis.ConclusionsFLT3i safely improved prognosis in induction/reinduction stage of FLT3(+) AML and further boosted survival benefits from allo-HSCT as maintenance therapy, suggesting better prognosis if FLT3i is combined before and after allo-HSCT. In NMA, gilteritinib potentially achieved the best prognosis, which should be identified in direct trials.
Metformin Adjunct With Antineoplastic Agents for the Treatment of Lung Cancer: A Meta-Analysis of Randomized Controlled Trials and Observational Cohort Studies
Authors: Luo Xiaofeng , Chen Xi , Wang Lin , Yang Bowen , Cai Shuang 
Published: June 2021

Objective: Resistance to anticancer agents ensures a poor prognosis in patients with lung cancer. Metformin could enhance the anticancer effects of standard antineoplastic agents [traditional chemotherapy drugs, epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), or immune checkpoint inhibitors (ICIs)]; however, it is unclear whether metformin can be combined with antineoplastic agents in the treatment of lung cancer. To explore the efficacy of combinational strategies, we performed a systematic review and meta-analysis for diabetic and non-diabetic patients with lung cancer.Method: An electronic literature search was performed to obtain relevant randomized controlled trials (RCTs) and observational cohort studies. Hazard ratios (HR) with 95% confidence intervals (CI) of overall survival (OS) and progression-free survival (PFS) outcomes were extracted. Subgroup analysis by antineoplastic agents, study type, histology and clinical stage were investigated.Results: 14 studies (three RCTs and eleven observational cohort studies) consisting 3,856 patients were included in the meta-analysis. Compared to standard antineoplastic agents alone (traditional chemotherapy drugs, EGFR-TKIs or ICIs), the antineoplastic agents combined with metformin significantly improved OS (HR 0.73, 95% CI 0.66–0.81, p &lt; 0.00001) and PFS (HR 0.72, 95% CI 0.59–0.88, p = 0.001); a similar association was found in observational evidence. Limited data from RCTs showed no differences in OS or PFS.Conclusion: Metformin plus antineoplastic agents may improve survival outcomes of patients with lung cancer. Further investigation is needed.
Aerobic Exercise During Advance Stage of Uncontrolled Arterial Hypertension
Authors: Pagan Luana U. , Gomes Mariana J. , Damatto Ricardo L. , Lima Aline R. R. , Cezar Marcelo D. M. , Damatto Felipe C. , Reyes David R. A. , Campos Dijon H. S. , Caldonazo Tulio M. M. , Polegato Bertha F. , Fernandes Denise C. , Laurindo Francisco R. , Fernandes Ana A. H. , Lloret Ana , Cicogna Antonio C. , Okoshi Marina P. , Okoshi Katashi 
Published: June 2021

AimTo evaluate the influence of physical training on myocardial function, oxidative stress, energy metabolism, and MAPKs and NF-κB signaling pathways in spontaneously hypertensive rats (SHR), at advanced stage of arterial hypertension, which precedes heart failure development.MethodsWe studied four experimental groups: normotensive Wistar rats (W, n = 27), trained W (W-EX, n = 31), SHR (n = 27), and exercised SHR (SHR-EX, n = 32). At 13 months old, the exercise groups underwent treadmill exercise 5 days a week for 4 months. In vitro myocardial function was analyzed in left ventricular (LV) papillary muscle preparations. Antioxidant enzyme activity and energy metabolism were assessed by spectrophotometry. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity was analyzed by lucigenin reduction and protein expression by Western blot. Statistical analyzes: ANOVA and Tukey or Kruskal–Wallis and Dunn tests.ResultsSHR-EX had a lower frequency of heart failure features than SHR. Myocardial function and antioxidant enzyme activity were better in SHR-EX than SHR. Lipid hydroperoxide concentration, and phosphorylated JNK and total IkB protein expression were higher in hypertensive than control groups. Malondialdehyde, NADPH oxidase activity, total JNK, phosphorylated p38, phosphorylated and total p65 NF-κB, and phosphorylated IkB did not differ between groups. Protein expression from total p38, and total and phosphorylated ERK were higher in SHR than W. Lactate dehydrogenase and phosphorylated ERK were lower and citrate synthase and β-hydroxyacyldehydrogenase were higher in SHR-EX than SHR.ConclusionExercise improves physical capacity, myocardial function, and antioxidant enzyme activity; reduces the frequency of heart failure features and ERK phosphorylation; and normalizes energy metabolism in SHR.
Resilience in Adult Health Science Revisited—A Narrative Review Synthesis of Process-Oriented Approaches
Authors: Hiebel Nina , Rabe Milena , Maus Katja , Peusquens Frank , Radbruch Lukas , Geiser Franziska 
Published: June 2021

Purpose: This article aims to identify how the term “resilience” is addressed in adult health science due to ongoing criticism about the lack of consistency in its conceptualization.Method: Two databases (PubMed and PsycArticles) were searched to retrieve reviews published from 2015 up until 2020 on the general conceptualization of resilience. All reviews had to meet specific inclusion criteria, which resulted in the inclusion of 18 articles. After discussing different conceptualizations regarding the process-oriented approach of resilience in adult health research, we will highlight some mechanisms that are supposed to be involved in the resilience process.Results: Research on resilience in health sciences confronts three core difficulties: defining positive outcome for a processual construct, describing different trajectories within the process, and identifying mechanisms that mediate resilience.Conclusion: The definition of resilience in mental health research as a multidimensional adaptation process is widely accepted, and multiple research paradigms have contributed to a better understanding of the concept. However, the definition of a processual construct in a way that allows for high expert consensus and a valid operationalization for empirical studies remains a challenge. Future research should focus on the assessment of multiple cross-domain outcomes and international and interdisciplinary prospective mixed-method longitudinal designs to fill in the missing links.
Alpha2-Adrenoblockers Regulate Development of Oxidative Stress and Cognitive Behaviour of Rats under Chronic Acoustic Stress Conditions
Authors: Melkonyan Magdalina , Manukyan Ashkhen , Hunanyan Lilit , Grigoryan Artem , Harutyunyan Hayk , Sukiasyan Lilit , Danielyan Lusine , Yenkoyan Konstantin 
Published: June 2021

Noise is a wide-spread stress factor in modern life produced by urbanization, traffic, and an industrialized environment. Noise stress causes dysfunction and neurotransmission impairment in the central nervous system, as well as changes in hormone levels. In this study, we have examined the level of α-Tocopherol (α-T) and malondialdehyde (MDA) in plasma and the erythrocytes’ membrane (EM), as well as the behavioral characteristics of a noise-induced stress model in rats. In addition, the modulating effect of α2-adrenoblockers, beditin, and mesedin on the aforementioned parameters has been investigated. For these purposes, albino male rats were divided into four groups: (1) untreated; (2) noise-exposed, (3) noise-exposed and beditin-treated (2 mg/kg, i.p.), and (4) noise-exposed and mesedin-treated (10 mg/kg, i.p.) animals. Noise-exposed groups were treated with 91dBA noise on 60 days with a daily duration of 8 h. Increased MDA and decreased α-T levels in plasma and EM were observed upon chronic high-level noise exposure. Locomotor and behavioral activity assessed with a Y-maze revealed disorientation and increased anxiety under chronic noise exposure. Prominently, α2-adrenoblockers alleviated both behavioral deficits and oxidative stress, providing evidence for the involvement of α2-adrenoceptor in the pathophysiology of noise-induced stress.
PENGARUH PENKES TERHADAP KECEMASAN IBU PADA BALITA YANG DILAKUKAN PEMASANGAN INFUS DI RS SILOAM SRIWIJAYA PALEMBANG
Authors: Hartati Sri , Maharani Shinta , Gultom Pebrin , Aini Lela 
Published: June 2021

ABSTRACT
One of the invasive procedures performed on children is therapy via intravenous (intravenous infusion). Anxiety experienced by parents can immediately be seen from changes in their behavior disorders. In this situation, the nurse's role as a source of information and support for the family. Information from medical personnel is needed for parents to monitor their child's condition time after time. Support for mothers as parents of children admitted to hospitals explains that parents feel calmer when the nursing team is able to provide support so that they
are able to form positive coping. This type of research is quantitative with pre-experimental research design using one group pretest posttest approach. The population in this study were all mothers who have children under five years old at Siloam Sriwijaya Hospital Palembang in 2019, while the number of samples taken in this study were 20 respondents. The results of the analysis showed that the average score of maternal anxiety in infants who had infused infants before being given health education was 59.00 and a standard deviation of 3.00. The maternal anxiety score for toddlers who underwent infusion before being given the lowest health education was 55 and the highest score was 65. The average anxiety score of mothers in toddlers who underwent infusion after being given health education was 52.90 and the standard deviation was 4.45. The maternal anxiety score for toddlers who performed infusion of toddlers after being given the lowest health education was 45 and the highest score was 61. There was an influence of health education on maternal anxiety for toddlers who performed infusion of toddlers at Siloam Sriwijaya Hospital Palembang in 2019 (ρ = 0,000) , with a difference in average score of 6.1 .. As for the advice given to the Officer not only focuses on physical assessment but also assesses the psychological parent of the child so that mothers who have abnormal anxiety get the right treatment.

Key Words

:

Health Education, Anxiety, Toddler Infusion Installation
PERBEDAAN TINGKAT KECEMASAN IBU HAMIL PRIMIGRAVIDA DAN MULTIGRAVIDA TRIMESTER III DENGAN PERILAKU IBU DALAM MENGHADAPI PERSALINAN DI KLINIK BERSALIN SRI KESUMA STR. KEB
Authors: Farizal Ekry binti 
Published: June 2021

Anxiety happens in almost maternal, in society. People still have the paradigm if considering that birth is the survival of life and death, so that the women who will give a birth get seared and frightened. Based on the purpose of this research. I want to find the differentiation of anxiety level of maternal behavior primigravida and multigravida in trimester III with thw behaviour of maternal in faching birth in Klinik bersalin Sri Kesuma STr. Keb Pangkalan Kerinci 2014. Based on the taken November 2019 the amount of maternal visit in clinic sri kesuma str. keb in 2018 is 396. The kind of research is analitycal and the design is cross sectional based on accidental sampling. It is used the frequency distribution and chi-square of statistical analytic. The result of this research is 66 maternal, 33 maternal of primigravida wich answered the quisioner (66,7%) including anxiety and negative behaviour is (54,5%) mean while the 33 maternal of multigravida wich got anxiety is (51,5%) with positive behaviour (57,6%). Based on the result of this research, most of maternal primigravida is got anxiety more with negative behaviour than maternal of multigravida with positive behaviour. Regarding that result, it is need the medical staff to give the information and midwifery especially to maternal of primigravida related to maternal behaviour in facing birth.
HUBUNGAN TINGKAT STRES DENGAN SIKLUS MENSTRUASI PADA REMAJA PUTRI DI SMAN 5 PEKANBARU TAHUN 2019
Authors: Angrainy Rizka , Yanti Penti Dora , Oktavia Elvi 
Published: June 2021

ABSTRACT

menstrual cycle are a series of events that are complexly affecting each other and occur simultaneously. Menstrual cycle can be influenced by stress factors. Stress is a perception of a threat or from a shadow of displeaseru that moves, alerts or activates an organism. Based on data obtained from the department of education the city of pekanbaru, it is known that schools which have the highest number of girls at SMAN 5 pekanbaru with the highest number of 639 people, while classes X and XI total 395 people and obtain information 8 people claimed to experince menstrual cycles that are not normal and as many as 6 of them experienced symptoms of stress. The purpose of this study was to determine the relationship between stress levels and menstrual cycle in young women at SMAN 5 pekanbaru. This type of research is quantitative with cross sectional design. The population is all young women and a sample of 80 people, taken by stratified random sampling technique. Data analysis was performed univariately and bivariately. The results obtained bye the majority of respondents had a moderate stress level of 31 people (38.8%) and for the menstrual cycle variable obtained the majority of respondents had a short menstrual cycle of 33 people (41.2%). Chi sqaure test results obtained p.value=0.012 <0.05, which means there is a relationship between the level of stress with the menstrual cycle in girls in SMAN 5 pekanbaru in 2019. being input and learning materials that add insight and increase knowledge for students at SMAN 5 cities pekanbaru.

Keywords: Stress, Menstrual Cycle
Reference: 19 (2004-2017)
Gestión de calidad y su relación con la formación académica del Piloto civil
Authors: Muñoz-Quintana Jonathan Franco , Napán-Yactayo Ana Cecilia 
Published: June 2021

El objetivo del estudio fue determinar la relación entre la gestión de calidad y la formación académica del piloto civil en las Escuelas de Aviación Civil del Perú. Esta investigación tuvo un enfoque cuantitativo, método hipotético deductivo, tipo aplicada, nivel correlacional, con diseño no experimental y corte transversal. La muestra estuvo conformada por 80 colaboradores de tres áreas, pilotos comerciales, pilotos de Línea Aérea y pilotos instructores. Los instrumentos obtuvieron un alfa de cronbach, GC (0.898) y FA (0.962). Los resultados indicaron una relación positiva moderada, con un Rho de Spearman (0.509), siendo la prueba significativa con un p valor = 0.000 <0.05. Esto quiere decir que algunos puntos están cerca de la línea, pero otros puntos están lejos de ella, lo que indica que solo existe una relación lineal moderada entre las variables. Se concluyó que a una mayor gestión de calidad existe una alta formación académica.