bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasound as a diagnostic tool for femoral head containment disorders in children between one and 12 years of age
Authors: Berger-Groch Josephine , Jandl Nico Maximilian , Strahl Andre , Bechler Ulrich , Beil Frank Timo , Stuecker Markus H.F. 
Published: August 2021

Purpose Ultrasound has been used to diagnose hip dysplasia in neonates and to screen until the end of their first year. For older children, femoral head containment disorders such as developmental dysplasia of the hip, Legg-Calvé-Perthes disease or cerebral palsy are usually diagnosed with plain radiographs. The aim of the present study was to evaluate ultrasound in comparison with radiographic imaging in children up to age 12 years and to determine reference values for sonographic containment parameters. Methods Hip ultrasound and radiographic imaging were acquired on the same day and then compared. As a reference, normal acetabular angle and acetabulum head index were determined on radiographs. Lateral cartilage distance (LCD), lateral head distance (LHD) and femoral head extrusion angle (HA) were measured on ultrasound images. Results We included 96 patients with 167 healthy hips in the study. A total of 55 patients were female and 41 male. The mean age was 5.2 years (sd 3.3; 1.0 to 11.9). LCDultrasound, LHDultrasound and HAultrasound correlated significantly with radiographic parameters. The following ultrasound values were calculated as limits for impending loss of containment: LCDultrasound ≥ 6.5 mm, LHDultrasound ≥ 3.3 mm and HAultrasound ≥ 27.6°. Conclusion Ultrasound is a simple, radiation-free diagnostic tool to detect femoral head containment disorders, even in children older than one year. This study provides reference values for hip ultrasound in children up to 12 years. Level of evidence III
<em>In vivo</em> model of Hirschsprung-associated enterocolitis using benzalkonium chloride
Authors: Budianto Iskandar Rahardjo , Firmansyah Agus , Moenadjat Yefta , Jusuf Ahmad Aulia , Soetikno Vivian 
Published: August 2021

BACKGROUND Hirschsprung-associated enterocolitis (HAEC) is a life-threatening complication of Hirschsprung’s disease. Studies using animal models on the pathogenesis of HAEC are limited. Thus, this study aimed to establish a rat model of HAEC using topical application of 0.1% benzalkonium chloride (BAC) in the sigmoid colon.
METHODS 55 male Sprague Dawley rats aged 10−12 weeks old were separated into 11 groups. The control group (n = 5) was euthanized on day-7, and the other 10 groups (n = 5 in each group) treated with 0.1% BAC in the sigmoid colon for 15 min to induce Hirschsprung’s disease were euthanized on day-7, -10, -12, -14, -17, -19, -21, -23, -25, and -28. The sigmoid colon was excised, fixed in formalin, and sectioned for histological examinations with hematoxylin and eosin staining. The degree of HAEC was compared within all groups.
RESULTS Rats that were sacrificed on day-7 to -12 showed the 1st degree or early HAEC, which was most likely caused by BAC application. The 2nd degree of HAEC occurred in rats that were sacrificed on day-14 that showed a macrophage infiltration in the sigmoid colon, thus fulfilled the initial criteria for HAEC (p = 0.0025 versus control). The degree of enterocolitis increased with time, and the highest degree was found in rats that were sacrificed on day-28 (p<0.001 versus control).
CONCLUSIONS Topical application of 0.1% BAC for 15 min was successfully produced HAEC model in rats, which was occurred on day-14 after the application. This model provides a useful resource for further research on the pathogenesis of HAEC.
Magnetic field vector sensor based on a cascaded structure of core-offset Fabry–Perot interferometer and a magnetic fluid infiltrated glass capillary
Authors: Zhang Junying , Jiang Yuanyuan , Zhang Xiongxing , Chen Haibin , Guo Zilong , Wang Wei 
Published: August 2021

A magnetic field vector sensor based on a cascaded structure composed of a core-offset Fabry–Perot interferometer (FPI) and a magnetic fluid (MF) infiltrated glass capillary (GC) is proposed and demonstrated. An air-gap FPI with a cavity length of 85 µm is formed by core-offset fusing two single-mode fibers separated by a short hollow-core fiber (HCF). The FPI is cascaded with an MF-infiltrated GC. By the directional bending effect of the core-offset FPI caused by magnetic field force on the MF-filtrated GC, the magnetic field can be monitored in strength and direction. Experimental results show that, in a magnetic field strength range of 0–9 mT, the sensor can achieve sensitivities of 4.63 and 4.25 pm/mT in two opposite directions.
Polarization-dependent broadband absorber based on composite metamaterials in the long-wavelength infrared range
Authors: Yu Haihong , Meng Dejia , Liang Zhongzhu , Xu Haiyang , Qin Zheng , Su Xuemei , Smith David R. , Liu Yichun 
Published: August 2021

Capturing polarization information has long been an important topic in the field of detection. In this study, two polarization-dependent broadband absorbers based on a composite metamaterial structure were designed and numerically investigated. Unlike in conventional metamaterial absorbers, the bottom metallic film is functionalized to achieve a polarization response or broadband absorption. The simulation results show that the type I absorber exhibits TM polarization-dependent broadband absorption (absorptivity>80%) from 8.37 µm to 12.12 µm. In contrast, the type II absorber presents TE polarization-dependent broadband absorption (absorptivity>80%) from 8.23 µm to 11.93 µm. These devices are extremely sensitive to the change of polarization angle. The absorptivity changes monotonically with an increase of the polarization angle, but it is insensitive to oblique incidence. This design paves the way for realizing broadband polarization-dependent absorption via a simple configuration. It has bright prospects in thermal detection applications and imaging fields.
“Designing high-performance nighttime thermoradiative systems for harvesting energy from outer space” by Zhang et  al.: comment
Authors: Pusch Andreas , Nielsen Michael P. , Sazzad Muhammad H. , Reece Peter J. , Ekins-Daukes Nicholas J. 
Published: August 2021

The current–voltage characteristics presented by Zhang et al. in their recent work [Opt. Lett.
45, 5929 (202010.1364/OL.400349)] on
designing thermoradiative systems overestimate the achievable power
using the proposed material by several orders of magnitude.
Original antigenic sin responses to Betacoronavirus spike proteins are observed in a mouse model, but are not apparent in children following SARS-CoV-2 infection
Authors: Lapp Stacey A. , Edara Venkata Viswanadh , Lu Austin , Lai Lilin , Hussaini Laila , Chahroudi Ann , Anderson Larry J. , Suthar Mehul S. , Anderson Evan J. , Rostad Christina A. 
Published: August 2021

Background
The effects of pre-existing endemic human coronavirus (HCoV) immunity on SARS-CoV-2 serologic and clinical responses are incompletely understood.

Objectives
We sought to determine the effects of prior exposure to HCoV Betacoronavirus HKU1 spike protein on serologic responses to SARS-CoV-2 spike protein after intramuscular administration in mice. We also sought to understand the baseline seroprevalence of HKU1 spike antibodies in healthy children and to measure their correlation with SARS-CoV-2 binding and neutralizing antibodies in children hospitalized with acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome (MIS-C).

Methods
Groups of 5 mice were injected intramuscularly with two doses of alum-adjuvanted HKU1 spike followed by SARS-CoV-2 spike; or the reciprocal regimen of SARS-Cov-2 spike followed by HKU1 spike. Sera collected 21 days following each injection was analyzed for IgG antibodies to HKU1 spike, SARS-CoV-2 spike, and SARS-CoV-2 neutralization. Sera from children hospitalized with acute COVID-19, MIS-C or healthy controls (n = 14 per group) were analyzed for these same antibodies.

Results
Mice primed with SARS-CoV-2 spike and boosted with HKU1 spike developed high titers of SARS-CoV-2 binding and neutralizing antibodies; however, mice primed with HKU1 spike and boosted with SARS-CoV-2 spike were unable to mount neutralizing antibodies to SARS-CoV-2. HKU1 spike antibodies were detected in all children with acute COVID-19, MIS-C, and healthy controls. Although children with MIS-C had significantly higher HKU1 spike titers than healthy children (GMT 37239 vs. 7551, P = 0.012), these titers correlated positively with both SARS-CoV-2 binding (r = 0.7577, P<0.001) and neutralizing (r = 0.6201, P = 0.001) antibodies.

Conclusions
Prior murine exposure to HKU1 spike protein completely impeded the development of neutralizing antibodies to SARS-CoV-2, consistent with original antigenic sin. In contrast, the presence of HKU1 spike IgG antibodies in children with acute COVID-19 or MIS-C was not associated with diminished neutralizing antibody responses to SARS-CoV-2.
Implementation of evidence-based practice: The experience of nurses and midwives
Authors: Dagne Asrat Hailu , Beshah Mekonnen Haile 
Published: August 2021

Background
Implementation of evidence-based practice in clinical practice is crucial. Nurses and midwives play a vital role in using updated evidence. However, limited support and barriers to implementing evidence-based practice hamper the use of up-to-date evidence in clinical decision-making practice. Therefore, this study aimed to explore the implementation of evidence-based practice of nurses and midwives working in public hospitals.

Methods
A qualitative descriptive study was conducted to explore the experience of implementing evidence-based practice among nurses and midwives working in public hospitals. A total of 86 participants, of which, 25 in-depth interviews, 5 FGDs having 47 participants and 14 participants were involved during observations, were considered in Amhara Region public hospitals from November 17, 2019 to April 25, 2020. The observational data, interview and FGD transcripts were imported into NVivo 12 plus to manage and analyze the data using the Computer-Assisted Data Analysis Software Program (CAQDAS). The data were analyzed through thematic content analysis.

Results
Nurses and midwives perceived that implementation of evidence-based practice is the use of research findings, guidelines, hospital protocols, books, and expert experience in clinical decision-making practice. However, there was limited support for the implementation of evidence-based practice by nurses and midwives. The lack of knowledge and skill to use evidence like research findings, time mismanagement, the lack of motivation, the lack of resources and training were the perceived barriers to the implementation of evidence-based practice. Stick to the traditional practice due to lack of incentive and unclear job description between diploma and BSc nurses and midwives were the perceived causes of the lack of motivation.

Conclusions
The experience of evidence-based practice of nurses and midwives indicated that there was limited support for the implementation of evidence-based practice. However, research findings were rarely used in clinical decision-making practice The Knowledge, attitude towards implementing evidence-based practice, lack of resources and training, time mismanagement and lack of motivation were the barriers to the implementation of evidence-based practice. Therefore, the promotion of adopting the implementation of evidence-based practice and training on the identified barriers are mandatory.
Gender effects on outcomes of psychosomatic rehabilitation are reduced
Authors: Burghardt Juliane , Riffer Friedrich , Sprung Manuel 
Published: August 2021

Objective
The study examined whether psychiatric/psychosomatic rehabilitation continues to have a better course of treatment for women than men.

Methods
We compared the course of global symptom severity, health-related quality of life and functioning between admission and discharge in patients (848 men, 1412 women) at an Austrian psychiatric/psychosomatic rehabilitation clinic.

Results
Gender-specific differences in the course of treatment were all too small to be clinically relevant. The differences were smallest in the middle-aged cohort. However, at the time of admission, women reported a slightly higher symptom burden.

Conclusion
Overall, the results show a gender-fair effectiveness of the rehabilitation. The new findings could be explained by changes in living conditions, gender roles, or better treatment methods.
Introduced marine macroalgae: new perspectives on species recognition and distribution in New Zealand
Authors: Nelson Wendy A. , D’Archino Roberta , Neill Kate F. , Robinson Nestor M. 
Published: August 2021

Abstract
The recognition of non-indigenous marine macroalgae in New Zealand and the potential pathways and vectors contributing to their arrival were discussed by Nancy Adams in 1983 along with a list of 14 species she considered to be “possibly naturalised”. In the following 38 years many more species have been identified as non-indigenous, a few of which have become widespread and invasive around New Zealand. We present an updated list of 61 taxa that we consider to have been introduced to the archipelago, and highlight a range of issues associated with the recognition of non-indigenous species, particularly increased taxonomic knowledge, the impact of an expanded collection baseline, as well as targeted investigations in New Zealand, increasing data availability globally, and the role of molecular tools for confirming species identifications and distinguishing cryptic species.
Clean-AR: Using Augmented Reality for Reducing the Risk of Contamination from Airborne Disease Agents on Surfaces
Authors: Yu Kevin , Ostler Daniel , Fuchtmann Jonas , Zapaishchykova Anna , Berlet Maximilian , Navab Nassir , Feussner Hubertus , Wilhelm Dirk 
Published: August 2021

Abstract
A core principle of modern health care is the compliance of hygienic and aseptic techniques in areas that are sensitive to contamination through bacteria, dust, aerosols, and fallout, primarily in operating theatres or around patients with contagious diseases. Keeping track of potentially contaminated surfaces in an environment is a major concern, especially when protecting from COVID-19. This work proposes a novel concept in using 3D sensing technology to track human movement within an indoor area and identifying high-risk contaminated surfaces in real-time. It combines recent Augmented Reality display technology, which allows keeping track of decontaminated surfaces during the cleaning process using an interactive visualization method. The proposed concept of Clean- AR is implemented in a clinical environment used for observation in COVID-19 scenarios. We discuss key challenges and outline further research direction in effectively reducing the risk of contamination using the proposed concept.
Usability of Haptic Volumetric Assistance for Surgical Navigation Tasks
Authors: Drobinsky Sergey , Lindeman Till , Schleer Philipp , Radermacher Klaus 
Published: August 2021

Abstract
Manual control of surgical instruments represents a sensorimotor control task with at least 3-6 degrees of freedom (DoF). The impact of haptic guidance on volumetric navigation tasks, such as milling of planned volumes for prosthesis fits or preserving sensitive tissues, is investigated. Interaction centered studies are performed to evaluate the usability of the assistance modes for navigation within a volume, along the surface of a volume and around forbidden regions. Results show that haptic assistance can reduce the number of constraint violations, if the virtual stiffness is high enough. However, haptic assistance also can increase error rates when counterforces are close to the absolute perception threshold, as a false sense of security can arise. For navigation along complex surfaces bilateral haptic constraints should be preferred, while unilateral constraints are sufficient for simple geometries. This study complements previous publications as a basis for a flexible rule-based selection or adaptation of modular haptic assistance systems.
AR visualization of automated access path planning for percutaneous interventions
Authors: Schwenderling Lovis , Hansen Christian , Heinrich Florian 
Published: August 2021

Abstract
Minimally invasive interventions, e.g., percutaneous needle interventions, have many advantages compared to traditional surgery. However, they may require complex and time-consuming planning with experience-dependent success. Automated access path planning is faster and more consistent but individual preferences and situational circumstances are not considered. To this end, displaying the path planning results directly on the patient’s skin, using projector-based augmented reality (AR), was investigated. A constraint-based path planning was implemented to evaluate the quality of every path, taking into account risk structures and path length. A visualization was developed to display the results on the skin and to allow for path selection. The choice of the path followed by a navigated insertion was evaluated in a pilot study (n=5), considering four levels of the visualization with different amounts of displayed insertion points. Participants stated that they preferred to have multiple potential puncture points displayed. However, the results for the considered variables show only small differences. Overall, it has been shown that projectorbased AR visualization of automated access path planning is possible and enables individual, situation-adapted insertion point selection. More research is required to further explore optimal display of paths.
A novel tool for monitoring and assessing the outcome of thermal ablations of hepatic lesions
Authors: Hille Georg , Brokmann Felicitas , Hensen Bennet , Alpers Julian , Wacker Frank , Saalfeld Sylvia 
Published: August 2021

Abstract
This paper presents a proof-of-concept intervention monitoring and outcome assessment tool for thermal ablative strategies like microwave ablation of hepatic tumours. For this purpose, simulated 3D+t temperature maps of the ablation progress are combined with liver MR imaging, as well as corresponding segmentations of the lesion and other relevant anatomical structures. The proposed tool mainly consists of a monitoring and validation part, each comprising 2D and 3D visualisations and various modifiable settings. With the aid of the monitoring features, the heat propagation during the ablation progress could be visually tracked, while the validation part of the tool provides the radiologist with comprehensible and detailed feedback to assess the treatment result. Hence, it could enable an immediate validation of the ablation progress and support interventional decision-making. For evaluation purposes, we used an exemplary patient case to demonstrate the benefits of the proposed prototype. This tool could represent a crucial step towards a suitable computerassisted and more accurate workflow of thermal ablations, with benefits for both, patients and radiologists.
Segmentation of the Scaphoid Bone in Ultrasound Images
Authors: Hohlmann Benjamin , Brößner Peter , Welle Kristian , Radermacher Klaus 
Published: August 2021

Abstract
For the percutaneous fixation of scaphoid fractures, navigated approaches have been proposed to facilitate screw placement. Based on ultrasound imaging, navigation can be carried out in a cost-effective and fast manner, furthermore avoiding harmful radiation. For this purpose, a fast and efficient architecture for the automated segmentation of scaphoid bone in ultrasound volume images is needed. Methods: For 2D segmentation of the scaphoid, two architectures are taken into account: 2D nnUNet and Deeplabv3+. These architectures are trained and evaluated on a newly created dataset consisting of 67 annotated in-vivo ultrasound volume images (4576 slice images). Results: In terms of Dice coefficient, the 2D nnUNet achieves 0.67 compared to 0.57 for the Deeplabv3+. In terms of distance metrics, the 2D nnUNet shows an average symmetric surface distance error of 0.66mm, while the Deeplabv3+ achieves 0.55mm. Conclusion: Fast and accurate segmentation of the scaphoid in ultrasound volumes is feasible. Both architectures show competitive results.
Superimposing holograms on real world objects using HoloLens 2 and its depth camera
Authors: Haxthausen Felix von , Chen Yenjung , Ernst Floris 
Published: August 2021

Abstract
Augmented Reality glasses such as HoloLens 2 may provide visual guidance during surgical interventions. To superimpose the holograms on real world objects (RWO), for instance a patient, spatial registration is required. In this work, we propose an approach to automatically register a hologram to the according RWO. To this end, the framework utilizes the depth camera of HoloLens 2 to acquire the point cloud (PC) of the RWO. A novel and recently published PC registration algorithm allows to register the PC of the RWO and the hologram after a rough initial placement without any need for pre-processing or outlier removal. The approach is evaluated by measuring displacements between certain known positions of the hologram and the RWO. The first metric relies on measuring points using an optically tracked stylus while the second is based on visually perceived positions. The median displacements were 22.3 mm, 35.6 mm, and 13.3 mm for the x-, y-, and z-axes in the first metric and 8.1 mm, 4.3 mm, and 11.9 mm for the second metric. Even though the accuracy is not yet adequate for many surgical interventions, the framework provides an initial step for a convenient marker less registration of holograms to an RWO.
Towards a companion system for collision avoidance during robot-assisted needle placement
Authors: Currle Eva , Hemm Johannes , Schäfer Armin , Beckerle Philipp , Horsch Johannes , Stallkamp Jan , Kühne Markus 
Published: August 2021

Abstract
Robotic assistance systems for surgery enable fast and precise interventions with reduced complication rates. However, these benefits are accompanied by a more complex operating room (OR) and the risk of collision with robotic assistance systems. Current strategies for collision avoidance and minimizing possible injuries require the adaptation of robotic trajectories and a computational model of the surroundings. In contrast, this work presents a novel companion system for collision avoidance without influencing robotic trajectories. The companion system consists of a preoperative planning application and an augmented reality application for intraoperative support. The companion system visualizes the workflow within the OR and allows robot movements to be seen virtually, before they are executed by the actual robotic assistance system. Preliminary experiments with users imply that the companion system leads to a positive user experience, enables users to follow a predefined workflow in the OR, but requires further refinement to improve accuracy for practical collision avoidance.