bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Dan Implementasi Sistem Pendukung Keputusan Dengan Metode Topsis Mengidentifikasi Kecamatan Terbaik Di Kota Tanjungbalai
Authors: Pratama M Rizky , Yesputra Rolly , Sudarmin Sudarmin 
Published: August 2021

Abstract: The Tanjungbalai City Government annually conducts an assessment of the best sub-district using existing indicators. So far, the assessment has only used Microsoft Excel calculations so that the time used to carry out the assessment process seems long and slow. To overcome these problems, a solution method with accuracy and speed in making the best district assessment decisions is needed. The Decision Support System was made using the Laravel framework and the MariaDB database and the method used was TOPSIS. The results of the best sub-district assessment using a Decision Support System with the TOPSIS method are needed to assist the assessment team in carrying out a faster assessment process so that the results obtained are much better. Analysis and implementation of a decision support system using the TOPSIS method to classify the best sub-districts in Tanjungbalai City facilitates the decision-making process to be faster and better for the Tanjungbalai City Regional Secretariat, especially in the Government section in choosing the best District based on existing criteria. The results of processing the system are 100% the same as the results of manual processing. Therefore this system is very helpful in speeding up work.Keyword: Decision support system; TOPSIS; Best District Assessment. Abstrak: Pemerintah Kota Tanjungbalai setiap tahunnya mengadakan penilaian Kecamatan terbaik dengan menggunakan indikator-indikator yang ada. Selama ini penilaian yang dilakukan hanya menggunakan perhitungan Microsoft Excel sehingga waktu yang digunakan untuk melakukan proses penilaian terkesan lama dan lambat. Untuk mengatasi permasalahan tersebut maka diperlukanlah metode penyelesaian dengan ketepatan dan kecepatan pada pengambilan keputusan penilaian kecamatan terbaik. Sistem Pendukung Keputusan tersebut dibuat menggunakan framework Laravel dan basis data MariaDB serta metode yang digunakan adalah TOPSIS. Hasil dari Penilaian kecamatan terbaik menggunakan Sistem Pendukung Keputusan dengan metode TOPSIS sangat dibutuhkan untuk membantu tim penilai dalam melaksanakan proses penilaian yang lebih cepat agar hasil yang akan didapatkan jauh lebih baik. Analisis dan implementasi sistem pendukung keputusan dengan metode TOPSIS mengklasifikasi kecamatan terbaik di Kota Tanjungbalai memudahkan proses pengambilan keputusan menjadi lebih cepat dan lebih bagus kepada Sekretaraiat Daerah Kota Tanjungabalai khususnya dibagian Pemerintahan dalam memilih Kecamatan terbaik berdasarkan kriteria/indikator yang ada. Hasil pengolahan sistem 100 % sama dengan hasil pengolahan secara manual. Maka dari itu sistem ini sangat membantu dalam mempercepat pekerjaan.Kata Kunci : Sistem Pendukung Keputusan;TOPSIS;Penilaian Kecamatan Terbaik.
Dose cardíaca nos tratamentos radioterápicos para câncer de mama esquerda: uso da técnica Deep Inspiration Breath Hold
Authors: Silva Charlene da , Dorow Patrícia Fernanda , Müller Juliana dos Santos , Piedade Pedro Argôlo 
Published: August 2021

Introdução: o tratamento radioterápico para câncer de mama esquerda tem como consequência a cardiotoxicidade induzida por radiação. A partir da necessidade de minimizar as doses cardíacas, surgiu a técnica Deep Inspiration Breath Hold (DIBH). Objetivo: descrever as doses nas estruturas cardíacas por meio do Histograma Dose Volume (DVH) no tratamento radioterápico para câncer de mama esquerda com a técnica DIBH. Metodologia: a pesquisa se caracterizada como estudo de caso com múltiplas unidades de análise, do tipo descritivo, de natureza retrospectiva e com abordagem quantitativa. Resultados: a amostra foi composta por cinco unidades de análise. A dose média cardíaca para a técnica DIBH foi de 6 Gy; e para a artéria coronária descendente anterior esquerda, esta foi de 14,8 Gy. Quatro unidades de análise foram mais beneficiadas com a técnica, o resultado é justificado pela modalidade cirúrgica conservadora, enquanto uma unidade apresentou o menor benefício, uma vez que realizou mastectomia. Conclusão: a DIBH é uma alternativa para reduzir a toxicidade cardíaca em mulheres que realizam radioterapia para câncer de mama esquerda, principalmente em indivíduos que possuem outros fatores de risco associados à doença cardíaca.
Xenogeneic collagen matrix for the treatment of multiple gingival recessions in esthetics areas: a case series with 24-month follow-up
Authors: Michel Raphaella Coelho , Ferreira Rafael , Carvalho Erika Beatriz Spada de , Jurkevicz Talyta Sasaki , Damante Carla Andreotti , Sant’Ana Adriana Campos Passanezi , Zangrando Mariana Schutzer Ragghianti 
Published: August 2021

Introduction: Multiple gingival recessions (GR) are often associated with high hypersensitivity and esthetics concerns due to exposed roots. The collagen matrix (CM) associated with coronally advanced flap (CAF) may be a suitable treatment for multiple GR in esthetic areas. However, there is a lack of long term follow up investigations. Objective: To evaluate a 24-month follow-up of the CM + CAF treatment for multiple RT1 GRs in esthetics areas. Materials and Methods: Six patients presenting 6 adjacent Cairo’s gingival recessions type 1 (RT1) in the anterior maxilla were treated with CM + CAF, and based on these patients a brief statistical analysis was conduct. The evaluated parameters included gingival recession depth (GRD), gingival recession width (GRW), probing depth (PD), clinical attachment level (CAL), keratinized tissue width (KTW), gingival thickness (GT), and mean root coverage (MRC). Patient-related outcomes measurements (PROMs) were assessed using an oral health impact profile (OHIP-14) questionnaire and visual analogue scale (VAS). Results: There was significant improvement in GRD, GRW, and CAL measurements at 3 months postoperatively (p<0.05). Besides, CAL also increased from 12 months to 24 months’ follow-up (p=0.0023). The MRC percentage was 82%. PD, GT, and KTW presented no statistical difference. PROMs revealed a high score for esthetics (82.2%) and a significant reduction in hypersensitivity and surgical pain/discomfort. Conclusions: Considering the limitations of a case series, the use of CM + CAF on RT1 multiple gingival recessions in esthetic areas demonstrated positive outcomes after 24 months.
Efeito do treinamento combinado de baixa intensidade e o controle da glicemia em idosos diabéticos tipo 2
Authors: Costa Ruth  Silva Lima da , Souza Juliana Magalhães de , Bussons Luiz Fernando de Souza , Carneiro Rafyck Mohamed Almeida , Silva João Rafael Valentim 
Published: August 2021

O objetivo foi investigar o efeito do treinamento combinado de baixa intensidade duas vezes por semana sobre a glicemia de idosos diabéticos tipo 2. Trata-se de um estudo semi-experimental, longitudinal, quantitativo, de dados primários que fez uma comparação entre momentos pré-intervenção com momentos pós-intervenção. Foi selecionado de maneira conveniente um grupo voluntário de 26 idosos, de ambos os sexos, diabéticos tipo 2, acompanhados em uma unidade básica de saúde. Foram realizadas análises quantitativas e qualitativas das coletas de glicemia capilar pós-prandial, por período de 30 dias e realizadas sessões de exercícios duas vezes por semana, de aproximadamente 50 minutos, de intensidade baixa, estimada pela escala de Borg. Para se comparar os resultados intragrupo e entre sujeitos do sexo feminino e masculino foram utilizados os testes de Shapiro-Wilks para se determinar a normalidade dos dados em seguida a Anova Ane Way com o Post Hoc de Tukey’s todo com significância de 5% por meio do programa PrismStat 5.0. Após as comparações do grupo total do momento pré-intervenção com os momentos após o início da intervenção, não houve diferença estatística entre eles, efeito semelhante quando comparados por sexo, onde os resultados não demostraram diferenças (p>0,05). Sendo assim, o exercício de baixa intensidade, duas vezes por semana aplicados à idoso diabético não foi capaz de causar efeitos adicionais nos níveis glicêmicos dos participantes.
Comentários sobre o TDAH na educação de jovens e adultos: uma mini revisão.
Authors: Trevisan Kaynara , Mesquita Ana Paula Bond , Pereira Renata Cristina , Aversi-Ferreira Tales Alexandre 
Published: August 2021

O transtorno de déficit de atenção [TDAH] é considerado como um problema que ocorre principalmente em crianças e que dificulta a vida do estudante pela falta de compreensão do problema pelos professores e família do individuo afetado por esse transtorno, o que gera problemas comportamentais e de convivência social. Esse problema pode persistir no adulto e, além de ser negligenciado em crianças e jovens, o é ainda mais no adulto. Dentro desse escopo, essa revisão sistemática foi efetuada para verificar e alertar sobre o TDAH em adultos e os problemas que afetam os estudantes universitários que sofrem o transtorno. Em conclusão, foi verificado que o TDAH em adultos é, de fato, negligenciado e que problemas no relacionamento social e com professores afetam as atividades acadêmicas e que o professores universitários, em geral, principalmente aqueles que não possuem formação pedagógica, não estão preparados para compreender a situação dos estudantes afetados, podendo levar à evasão escolar e problemas psicológicos mais graves do que o próprio TDAH.
Importância da nova lei para higienização de carrinhos de supermercados: questões diretas e indiretas
Authors: Rachid Lorena Queiroz , Dualibi Sandra , Araújo Bruna Silva 
Published: August 2021

O objetivo deste estudo é discutir a importância da segurança do alimento e a proteção do consumidor na utilização dos carrinhos de supermercado. Trata-se de uma revisão de literatura na busca de artigos realizada na Biblioteca Virtual (Scielo) e CAPES, utilizando descritores referentes à micro-organismos, contaminação cruzada, Boas Práticas de Fabricação, higienização de carrinhos em supermercados, segurança do alimento e fiscalização sanitária. Ainda, foram consultadas as referências dos artigos selecionados, a fim de identificar outros estudos. O presente estudo caracteriza-se quanto ao objetivo em uma pesquisa explicativa que tenha como propósito identificar fatores que determinam ou contribuam para a ocorrência de fenômenos. Quanto ao delineamento, a pesquisa configura um estudo bibliográfico, esta se caracteriza pelo estudo de materiais já elaborados. A pesquisa bibliográfica também é utilizada para catalogar as produções científicas. Quanto à natureza, o estudo se classifica como qualitativo, pois é procedida uma análise sobre o conteúdo escrito dos artigos, para se averiguar as principais metodologias adotadas nos estudos investigados. A técnica de coleta é uma documentação indireta com documento e bibliografia, juntamente com técnicas de análise de dados qualitativas. Os dados encontrados contribuíram para resultados sobre avaliações realizadas no meio alimentício e os diversos patógenos encontrados nos diversos ambientes. O que remete as questões diretas e indiretas sobre contaminações advindas de higiene pessoal, ambiente de trabalho, animais no local, microrganismo de feira livres, condições higiêncio-sanitário, ou seja, esses requesitos mencionados contribuem para a proliferação de contaminantes. Sendo de muita importância a prevenção através da higienização e sanitização de ambientes, equipamentos e mãos. Conclui-se que é necessário o acompanhamento em longo prazo e de treinamentos em Boas Práticas de Fabricação nos estabelecimentos alimentícios para melhor alcance da padronização e controle da qualidade.
Lumbar Disc Herniation Automatic Detection in Magnetic Resonance Imaging Based on Deep Learning
Authors: Tsai Jen-Yung , Hung Isabella Yu-Ju , Guo Yue Leon , Jan Yih-Kuen , Lin Chih-Yang , Shih Tiffany Ting-Fang , Chen Bang-Bin , Lung Chi-Wen 
Published: August 2021

Background: Lumbar disc herniation (LDH) is among the most common causes of lower back pain and sciatica. The causes of LDH have not been fully elucidated but most likely involve a complex combination of mechanical and biological processes. Magnetic resonance imaging (MRI) is a tool most frequently used for LDH because it can show abnormal soft tissue areas around the spine. Deep learning models may be trained to recognize images with high speed and accuracy to diagnose LDH. Although the deep learning model requires huge numbers of image datasets to train and establish the best model, this study processed enhanced medical image features for training the small-scale deep learning dataset.Methods: We propose automatic detection to assist the initial LDH exam for lower back pain. The subjects were between 20 and 65 years old with at least 6 months of work experience. The deep learning method employed the YOLOv3 model to train and detect small object changes such as LDH on MRI. The dataset images were processed and combined with labeling and annotation from the radiologist’s diagnosis record.Results: Our method proves the possibility of using deep learning with a small-scale dataset with limited medical images. The highest mean average precision (mAP) was 92.4% at 550 images with data augmentation (550-aug), and the YOLOv3 LDH training was 100% with the best average precision at 550-aug among all datasets. This study used data augmentation to prevent under- or overfitting in an object detection model that was trained with the small-scale dataset.Conclusions: The data augmentation technique plays a crucial role in YOLOv3 training and detection results. This method displays a high possibility for rapid initial tests and auto-detection for a limited clinical dataset.
GADD45B Is a Potential Diagnostic and Therapeutic Target Gene in Chemotherapy-Resistant Prostate Cancer
Authors: Wang Qiong , Wu Wanhua , Gao Ze , Li Kaiwen , Peng Shirong , Fan Huiyang , Xie Zhongqiu , Guo Zhenghui , Huang Hai 
Published: August 2021

BackgroundChemoresistance is the major cause of death in advanced prostate cancer (PCa), especially in metastatic PCa (mPCa). However, the molecular mechanisms underlying the chemoresistance of PCa remain unclear. Understanding the reason behind the drug resistance would be helpful in developing new treatment approaches.MethodsThe Cancer Genome Atlas, Gene Expression Omnibus datasets, and clinical samples were used to examine the correlation between growth arrest and DNA damage-inducible 45 beta (GADD45B) with clinical characteristics and prognosis. Lentiviral transfection was used to construct GADD45B overexpression cell lines. Hypoxic incubator, low serum medium, or docetaxel was used to build environmental stress model or chemotherapy cell model. The MTS assay and colony formation assay were used to test cell viability. Apoptosis and cell cycle were detected by flow cytometry. The RNA and protein levels of related biomarkers were tested by Western blotting and quantitative polymerase chain reaction. Bioinformatics analysis after RNA sequencing was performed to identify the possible mechanism of how GADD45B regulates chemotherapy resistance.ResultsGADD45B was related to distant metastasis but not to Gleason score, prostate-specific antigen level, T stage, or lymph node metastasis and indicated a good prognosis. The level of GADD45B increased significantly in PCa cells that faced environmental stress. It was found that a high level of GADD45B significantly enhanced the chemosensitivity. Furthermore, high GADD45B promoted cell apoptosis via mitogen-activated protein kinase (MAPK) pathway.ConclusionGADD45B promoted chemosensitivity of prostate cancer through MAPK pathway. GADD45B could serve as a diagnostic biomarker and therapeutic target for mPCa or chemotherapy-resistant patients.
Perivascular Adipose-Derived Exosomes Reduce Foam Cell Formation by Regulating Expression of Cholesterol Transporters
Authors: Liu Yan , Sun Yan , Lin Xuze , Zhang Dai , Hu Chengping , Liu Jinxing , Zhu Yong , Gao Ang , Han Hongya , Chai Meng , Zhang Jianwei , Zhou Yujie , Zhao Yingxin 
Published: August 2021

Background: Accumulating evidence demonstrates that perivascular adipose tissue (PVAT) plays an important role in maintaining vascular homeostasis. The formation of macrophage foam cells is a central feature of atherosclerosis. This study aimed to evaluate the effect of PVAT-derived exosomes (EXOs) on the lipid accumulation of macrophages and verify the anti-atherogenic characteristics of PVAT.Methods and Results: We extracted EXOs from the PVAT and subcutaneous adipose tissue (SCAT) of wild-type C57BL/6J mice. After coincubation, the EXOs were taken up by RAW264.7 cells. Oil Red O staining revealed that macrophage foam cell formation and intracellular lipid accumulation were ameliorated by PVAT-EXOs. Flow cytometry showed that PVAT-EXOs significantly reduced macrophage uptake of fluorescence-labelled oxidised low-density lipoprotein (ox-LDL). In addition, high-density lipoprotein-induced cholesterol efflux was promoted by PVAT-EXOs. Western blot analysis showed the downregulation of macrophage scavenger receptor A and the upregulation of ATP-binding cassette transporter A1 and ATP-binding cassette transporter G1, which could be mediated by the overexpression of peroxisome proliferator-activated receptor γ and was independent of liver X receptor α.Conclusion: Our findings suggest that PVAT-EXOs reduce macrophage foam cell formation by regulating the expression of cholesterol transport proteins, which provides a novel mechanism by which PVAT protects the vasculature from atherosclerosis.
Observations of the Effects of Maternal Fasting Plasma Glucose Changes in Early Pregnancy on Fetal Growth Profiles and Birth Outcomes
Authors: Guo Fei , Liu Yindi , Ding Zheng , Zhang Yong , Zhang Chen , Fan Jianxia 
Published: August 2021

IntroductionAlthough the role of maternal hyperglycemia on birth outcomes is clear, literature regarding fetal growth is scarce. We examined the possible associations between maternal fasting plasma glucose (FPG) and fetal growth.Materials and MethodsA total of 35,981 singleton-pregnant women with FPG in the first trimester were included. Fetal growth parameters were measured during pregnancy by ultrasound at mid and late pregnancy. Information on birth characteristics was retrieved from medical records. We used multivariable linear and logistic regression to determine the associations between FPG and z-scores of fetal parameters and risks of birth outcomes and to assess effect modification by maternal characteristics.ResultsA per-unit increase in FPG levels was negatively associated with fetal parameters in mid pregnancy but positively correlated with those in late pregnancy and with birth characteristics. The effect estimates in late pregnancy were attenuated by maternal pre-pregnancy body mass index (BMI). A significant relationship between FPG and abdominal circumference (AC), an indicator of fetal adiposity, was sustained in subgroups of women with advanced age, positive family history of diabetes, and multiparity in fully adjusted models. After stratification by BMI, high FPG was associated with accelerated AC only in normal controls (0.044 SD; 95% CI: 0.010, 0.079) and overweight/obese women (0.069 SD; 95% CI: -0.002, 0.140) but not in underweight women. High FPG was an independent risk factor for large-for-gestational age in the whole group and stratified subgroups.ConclusionsIncreased FPG in early pregnancy is closely related to fetal growth. Maternal characteristics may modify the associations between FPG and fetal adiposity in late pregnancy.
Towards Good E-Flows Practices in the Small-Scale Hydropower Sector in Uganda
Authors: O’Brien G. C. , Dickens C. W. S. , Mor C. , England M. I. 
Published: August 2021

Stakeholders of the small-scale (&lt;50 MW generation capacity) hydropower sector in Uganda recognise the importance of sustainable development of the resources that have social and ecological importance. Uganda is experiencing a boom in hydropower projects resulting in over generation of electricity and its exportation to neighbouring nations. Limited policies are currently available in Uganda to direct the sustainable development of this sector. Environmental flows (e-flows) practices established for the Nile Basin region and international good e-flows practices can contribute to sustainable management of hydropower developments in Uganda. The paper defines and explains e-flows, identifies water resource attributes of importance for e-flows determination associated with hydropower and threat associated with this activity in Uganda, and provides good e-flows determination and management practices based on regional and international information. The determination and management of e-flows in the hydropower sector in Uganda is largely dependent on the availability of and quality of hydrology, hydraulic and flow-ecosystem and flow-ecosystem service relationship information. This review of good-practice e-flows practice for the small hydropower sector in Uganda provides guidance to support multiple stakeholders of water resources in Uganda for a better future for all of its vulnerable communities and the environments they depend on.
Co-Designing Urban Carbon Sink Parks: Case Carbon Lane in Helsinki
Authors: Tammeorg Priit , Soronen Päivi , Riikonen Anu , Salo Esko , Tikka Suvi , Koivunen Minja , Salonen Anna-Reetta , Kopakkala Topi , Jalas Mikko 
Published: August 2021

In order to achieve the goals of carbon (C) neutrality within next 20 year, municipalities worldwide need to increasingly apply negative emission technologies. We focus on the main principles of urban demonstration areas using biochars for C sequestration and explore the lessons learned from a co-creation process of one such park, Hyväntoivonpuisto in Helsinki, Finland. Demonstration sites of urban C sinks in public parks must be safe, visible and scientifically sound for reliable and cost-effective verification of carbon sequestration. We find that different interests can be arbitrated and that synergy that emerges from co-creation of urban C sink parks between stakeholders (scientists, city officials, companies, and citizens) can result in demo areas with maximized potential for impact, dissemination and consideration of principles of scientific experimentation.