bluuebunny/crossref_metadata_2025_split huggingface dataset:
Traditional Chinese Mind and Body Exercises for Neck Pain: A Meta-Analysis of Randomized Controlled Trials
Authors: Xie Yu-Hua , Liao Man-Xia , Wang Mao-Yuan , Fernando W. C. Hewith A. , Gu Yue-Ming , Wang Xue-Qiang , Liao Lin-Rong 
Published: October 2021

Background. Neck pain is common and can have a significant impact on patients’ physical functionality, mobility, and quality of life (QOL). In clinical practice, traditional Chinese mind and body exercise (TCMBE) is a combination of different types of exercise based on traditional Chinese medicine, including qigong, tai chi, the 12-words-for-life-nurturing exercise, and so on, and many studies have found that it is safe and effective at helping patients with neck pain. Objective. The aim of this study was to investigate the effectiveness of TCMBE on pain intensity, functional mobility, and QOL in individuals with neck pain. Methods. The PubMed, MEDLINE, PEDro, and Embase databases were systematically searched for relevant studies. Randomized controlled trials reporting the effects of TCMBE on pain intensity, functional mobility, and QOL in individuals with neck pain were included. Screening, data extraction, and literature quality assessments were performed independently by two reviewers. RevMan5.4 software was used for data analysis. Results. Six studies with 716 participants met the inclusion criteria. Compared with the control groups, TCMBE had no therapeutic advantage in improving pain intensity (visual analogue scale: mean difference (MD) = 1.8, 95% confidence interval (CI): −7.70 to 11.46, and

P

= 0.70); functional mobility (neck disability index: MD = 0.15, 95% CI: −6.37 to 6.66, and

P

= 0.96; neck pain and disability scale: MD = 1.31, 95% CI: −4.10 to 6.71, and

P

= 0.64); or 36-item short-form health survey (SF-36) scores for physical function (MD = 5.58, 95% CI: −8.03 to 19.18, and

P

= 0.42), general health (MD = 1.87, 95% CI: −4.99 to 8.72, and

P

= 0.59), body pain (MD = 2.26, 95% CI: −3.80 to 8.32, and

P

= 0.46), vitality (MD = 6.24, 95% CI: −1.49 to 13.98, and

P

= 0.11), social function (MD = 8.06, 95% CI: −4.85 to 20.98, and

P

= 0.22), role physical (MD = –1.46, 95% CI: −8.54 to 5.62, and

P

= 0.69), or role emotional (MD = 6.5, 95% CI: −3.45 to 16.45, and

P

= 0.2). However, TCMBE was less effective at improving mental health results based on the SF-36 survey (MD = 3.37, 95% CI: 0.5 to 6.24, and

P

= 0.02). Conclusions. Based on the meta-analysis, there is insufficient evidence to support the clinical use of TCMBE in improving pain intensity and enhancing functional mobility and QOL in individuals with neck pain.
The Hecke Group
H

λ

4

Acting on Imaginary Quadratic Number Fields
Authors: Deajim Abdulaziz 
Published: October 2021

Let

H

λ

4

be the Hecke group

x
,
y
:

x

2

=

y

4

=
1

and, for a square-free positive integer

n

, consider the subset

ℚ

∗

−
n

=

a
+

−
n

/
c

|

a
,
b
=

a

2

+
n

/
c

∈
ℤ
,

c
∈
2
ℤ

of the quadratic imaginary number field

ℚ

−
n

. Following a line of research in the relevant literature, we study the properties of the action of

H

λ

4

on

ℚ

∗

−
n

. In particular, we calculate the number of orbits arising from this action for every such

n

. Some illustrative examples are also given.
Preparation, Characterization, and Evaluation of Rutin Nanocrystals as an Anticancer Agent against Head and Neck Squamous Cell Carcinoma Cell Line
Authors: Bohlouli Sepideh , Jafarmadar Gharehbagh Faezeh , Dalir Abdolahinia Elaheh , Kouhsoltani Maryam , Ebrahimi Ghasem , Roshangar Leila , Imani Amir , Sharifi Simin , Maleki Dizaj Solmaz 
Published: October 2021

The reports show that rutin has good potentials as an anticancer agent; however, rutin has poor bioavailability due to its low aqueous solubility. The present study was aimed at preparing and evaluating physicochemical properties as well as the anticancer activities of rutin nanocrystals (RNs). RNs were prepared via the ultrasonication method. The prepared nanocrystals then were physicochemically characterized by the conventional techniques. The cytotoxic effect of RNs and free rutin on the HN5 head and neck squamous carcinoma cell line was assessed. The HGF1-PI1 cells as normal oral cells were treated by RNs. Cells were also exposed to rutin and RNs to determine their effects on the expression of caspase-8, caspase-9, Bcl-2, and Bax genes. The prepared RNs have a mean particle size of

75
±
0.16

nm and quasispherical morphology. Rutin displayed no significant cytotoxic effect on HN5 cells to 2000 μM. However, RNs displayed a cytotoxic effect with IC50 of 30.51 μM and 27.34 μM in 24 and 48 h incubation times, respectively (

p
<
0.05

). RNs had cytotoxic effect 100 times more than rutin on HN5 cells. There was no significant cytotoxic effect on HGF1-PI1 treated by RNs in 24 and 48 h. The expression of Bcl-2 mRNA was significantly decreased in attendance of RNs compared to the control group (

p
<
0.05

). The increase in Bax/Bcl-2 ratio was revealed within IC50 of RNs in 24 h. Our results confirm that the anticancer effect of RNs is significantly more than that of rutin. The activation of the mitochondria-dependent apoptotic pathway of RNs occurred via modulation of Bcl-2 and Bax expression. These results suggest that RNs may be useful in the development of a cancer therapy protocol.
Response to Rucaparib in BRCA-Mutant Metastatic Castration-Resistant Prostate Cancer Identified by Genomic Testing in the TRITON2 Study
Authors: Loehr Andrea , Patnaik Akash , Campbell David , Shapiro Jeremy , Bryce Alan H. , McDermott Ray , Sautois Brieuc , Vogelzang Nicholas J. , Bambury Richard M. , Voog Eric , Zhang Jingsong , Piulats Josep M. , Hussain Arif , Ryan Charles J. , Merseburger Axel S. , Daugaard Gedske , Heidenreich Axel , Fizazi Karim , Higano Celestia S. , Krieger Laurence E. , Sternberg Cora N. , Watkins Simon P. , Despain Darrin , Simmons Andrew D. , Dowson Melanie , Golsorkhi Tony , Chowdhury Simon , Abida Wassim 
Published: October 2021

AbstractPurpose:The PARP inhibitor rucaparib is approved in the United States for patients with metastatic castration-resistant prostate cancer (mCRPC) and a deleterious germline and/or somatic BRCA1 or BRCA2 (BRCA) alteration. While sequencing of tumor tissue is considered the standard for identifying patients with BRCA alterations (BRCA+), plasma profiling may provide a minimally invasive option to select patients for rucaparib treatment. Here, we report clinical efficacy in patients with BRCA+ mCRPC identified through central plasma, central tissue, or local genomic testing and enrolled in TRITON2.Patients and Methods:Patients had progressed after next-generation androgen receptor–directed and taxane-based therapies for mCRPC and had BRCA alterations identified by central sequencing of plasma and/or tissue samples or local genomic testing. Concordance of plasma/tissue BRCA status and objective response rate and prostate-specific antigen (PSA) response rates were summarized.Results:TRITON2 enrolled 115 patients with BRCA+ identified by central plasma (n = 34), central tissue (n = 37), or local (n = 44) testing. Plasma/tissue concordance was determined in 38 patients with paired samples and was 47% in 19 patients with a somatic BRCA alteration. No statistically significant differences were observed between objective and PSA response rates to rucaparib across the 3 assay groups. Patients unable to provide tissue samples and tested solely by plasma assay responded at rates no different from patients identified as BRCA+ by tissue testing.Conclusions:Plasma, tissue, and local testing of mCRPC patients can be used to identify men with BRCA+ mCRPC who can benefit from treatment with the PARP inhibitor rucaparib.
An Evolving Role for AXL in Metastatic Renal Cell Carcinoma
Authors: Hahn Andrew W. , George Daniel J. , Agarwal Neeraj 
Published: October 2021

Abstract
High tumoral expression of AXL was associated with inferior response to anti–PD-1 therapy and increased tumoral programmed death ligand 1 (PD-L1) expression in patients with metastatic renal cell carcinoma, with particularly poor outcomes in those with high AXL and PD-L1. AXL expression has potential as a biomarker and therapeutic target.
See related article by Terry et al., p. 6749
Pretreatment With P2Y12 Inhibitors in Patients With Chronic Coronary Syndrome Undergoing Percutaneous Coronary Intervention: A Report From the Swedish Coronary Angiography and Angioplasty Registry
Authors: Jurga Juliane , Szummer Karolina Elizabeth , Lewinter Christian , Mellbin Linda , Götberg Matthias , Zwackman Sammy , Nilsson Johan , Völz Sebastian , Erlinge David , Persson Jonas , Omerovic Elmir , Jernberg Tomas , Venetsanos Dimitrios 
Published: October 2021

Background:
In patients with chronic coronary syndrome undergoing percutaneous coronary intervention, the optimal timing of P2Y12 inhibitors’ administration is uncertain. We compared pretreatment versus treatment in the catheterization laboratory (In-Cathlab) in a real-world population.

Methods:
In Swedish Coronary Angiography and Angioplasty Registry, all patients with chronic coronary syndrome undergoing coronary angiography and ad hoc percutaneous coronary intervention, between 2006 and 2017 were identified. Pretreatment was defined as P2Y12 inhibitor administration before coronary angiography, outside the catheterization laboratory. Outcomes were net adverse clinical events including death, myocardial infarction, stroke, or bleeding within 30 days of the index procedure and in-hospital bleeding.

Results:
We included 26 814 patients, 8237 in the In-Cathlab, and 18 577 in the pretreatment group. In-Cathlab treatment compared with pretreatment was associated with lower risk for net adverse clinical event (4.2 versus 5.1%, adjusted hazard ratio 0.79 [0.63–0.99]), bleeding (2.3 versus 2.6%, adjusted hazard ratio, 0.76 [0.57–1.01]). and in-hospital bleeding (1.9 versus 2.1%, adjusted odds ratio, 0.70 [0.51–0.96]). The risk for death, myocardial infarction, or stroke did not significantly differ between the groups. Among the In-Cathlab treated patients, 41% received ticagrelor or prasugrel and 59% clopidogrel. Treatment with ticagrelor or prasugrel was associated with higher risk for net adverse clinical events (5.4% versus 3.4%, adjusted hazard ratio, 1.66 [1.12–2.48]), bleeding (3.4 versus 1.6%, adjusted hazard ratio, 2.14 [1.34–3.42]), and in-hospital bleeding (2.9 versus 1.2%, adjusted odds ratio, 2.24 [1.29–3.90]) but similar risk for death, myocardial infarction, or stroke, compared with clopidogrel.

Conclusions:
In patients with chronic coronary syndrome undergoing coronary angiography and ad hoc percutaneous coronary intervention, pretreatment with P2Y12 inhibitors, before arrival to the catheterization laboratory, was not associated with improved clinical outcomes but was associated with increased risk for bleeding. Our data support clopidogrel administration in the catheterization laboratory as the standard of care.

Graphic Abstract:

A
graphic abstract
is available for this article.
Conscious sedation versus general anesthesia for transcatheter aortic valve implantation in patients with severe chronic obstructive pulmonary disease
Authors: Aslan Serkan , Güner Ahmet , Demir Ali Rıza , Yılmaz Emre , Aslan Ayşe Feyza , Çelik Ömer , Uzun Fatih , Ertürk Mehmet 
Published: September 2021

Introduction: Chronic obstructive pulmonary disease (COPD) is considered a major risk factor for postoperative complications after transcatheter aortic valve implantation (TAVI). To date, there is no clear consensus on the best anesthesia management for these patients. We aimed to investigate the effects of types of anesthesia on clinical outcomes in patients with severe COPD undergoing TAVI. Methods: This is a single-center, retrospective study comparing conscious sedation (CS) versus general anesthesia (GA) in 72 patients with severe COPD who underwent TAVI. The primary endpoints were 30-day all-cause mortality and postoperative pulmonary complications. Results: The main outcome of interest of this study was that the frequency of pulmonary complications was statistically higher in the GA group (21.4% vs 3.3%, p = 0.038). These differences are most likely attributed to the GA because of prolonged mechanical ventilation, and longer ICU stay (2 (1.2–3) vs 2.5 (2–4) days, p = 0.029) associated with an increased risk of nosocomial infections. There were no significant differences in procedure complications and 30-day mortality between the two groups (GA; 19% vs CS; 13.3%, p = 0.521). One-year survival rates, compared by Kaplan-Meier analysis, were similar between groups (log-rank p = 0.733). Conclusion: In aortic stenosis patients with severe COPD undergoing TAVI, the use of GA compared with CS was associated with higher incidences of respiratory-related complications, and longer ICU length of stay. CS is a safe and viable option for these patients and should be considered the favored approach.
Expression and related mechanisms of miR-330-3p and S100B in an animal model of cartilage injury
Authors: Wu Wenming , Liang Dongming 
Published: September 2021

Objective To investigate the roles of and relationship between microRNA (miR)-330-3p and S100 calcium-binding protein B (S100B) in an animal model of cartilage injury. Methods This study included 30 New Zealand male rabbits randomly divided into three groups: an intervention group, a model group and a sham surgery control group. Modelling was performed in the intervention and model groups, but in the sham surgery group, only the skin was cut. After modelling, the intervention and model groups were injected with the miR-330-3p overexpression vector GV268-miR-330-3p or the control GV268-N-ODN vector, respectively, twice a week for 7 weeks. Results Levels of interleukin-1β and tumour necrosis factor-α in the synovial fluid were significantly higher in the model group than in the intervention and control groups. The level of miR-330-3p in the cartilage tissue was significantly higher in the control group than in the model group but it was significantly lower compared with the intervention group. Levels of S100B, fibroblast growth factor receptor 1 and fibroblast growth factor-2 in the cartilage tissue of rabbits in the model group were significantly higher compared with the control and intervention groups. Conclusion These findings demonstrate that the upregulation of miR-330-3p can inhibit the expression of S100B.
Puerarin induces platinum-resistant epithelial ovarian cancer cell apoptosis by targeting SIRT1
Authors: Duan Jianxiu , Yin Mingyuan , Shao Yaqin , Zheng Jiao , Nie Shengdan 
Published: September 2021

Objective Previous investigations indicated the anticancer activity of puerarin. The current study aimed to evaluate the effect and molecular mechanisms of puerarin in chemotherapy-resistant ovarian cancer cells. Methods We examined the effects of puerarin in platinum-resistant epithelial ovarian cancer cells in vitro and in vivo. We also analyzed the molecular mechanism underlying Wnt/β-catenin inhibition and sirtuin 1 (SIRT1) regulation following puerarin treatment. Results Our study demonstrated that puerarin effectively inhibited cell growth in vitro and in vivo by increasing apoptosis in ovarian cancer cells. More importantly, puerarin sensitized cisplatin-resistant ovarian cancer cells to chemotherapy. Puerarin treatment decreased SIRT1 expression, which attenuated the nuclear accumulation of β-catenin to inhibit Wnt/β-catenin signaling. In addition, SIRT1 overexpression diminished the effects of puerarin treatment on cisplatin-resistant ovarian cancer cells. Further analysis supported SIRT1/β-catenin expression as a candidate biomarker for the disease progression of epithelial ovarian cancer. Conclusions Puerarin increased the apoptosis of platinum-resistant ovarian cancer cells. The mechanism is partly related to the downregulation of SIRT1 and subsequent inhibition of Wnt/β-catenin signaling.
D-dimer Level and Diabetes in the COVID-19 Infection
Authors: Miri Chaymae , Charii Hajar , Bouazzaoui Mohammed-Amine , Laouan Brem Falmata , boulouiz Soumia , Abda Naima , Kouismi Hatim , Bazid Zakaria , Ismaili Nabila , El Ouafi Noha 
Published: September 2021

Introduction Diabetes is the most common of comorbidity in patients with SARS-COV-2 pneumonia. Coagulation abnormalities with D-dimer levels are increased in this disease. Objectifs We aimed to compare the levels of D-dimer in diabetic and non-diabetic patients with COVID 19. A link between D-dimer and mortality has also been established. Materials A retrospective study was carried out at the University Hospital Center of Oujda (Morocco) from November 01st to December 01st, 2020. Our study population was divided into two groups: a diabetic group and a second group without diabetes to compare clinical and biological characteristics between the two groups. In addition, the receiver operator characteristic curve was used to assess the optimal D-dimer cut-off point for predicting mortality in diabetics. Results 201 confirmed-COVID-19-patients were included in the final analysis. The median age was 64 (IQR 56-73), and 56% were male. Our study found that D-dimer levels were statistically higher in diabetic patients compared to non-diabetic patients. (1745 vs 845 respectively, P = 0001). D-dimer level > 2885 ng/mL was a significant predictor of mortality in diabetic patients with a sensitivity of 71,4% and a specificity of 70,7%. Conclusion Our study found that diabetics with COVID-19 are likely to develop hypercoagulation with a poor prognosis.
The Application of the ThroLy Risk Assessment Model to Predict Venous Thromboembolism in Patients with Diffuse Large B-Cell Lymphoma
Authors: Abdel-Razeq Hikmat , Ma’koseh Mohammad , Mansour Asem , Bater Rayan , Amarin Rula , Abufara Alaa , Halahleh Khalid , Manassra Mohammad , Alrwashdeh Mohammad , Almomani Mohammad , Zmaily Mais 
Published: September 2021

Background Patients with aggressive lymphomas are at higher risk for venous thromboembolism (VTE). ThroLy is a risk assessment model (RAM) derived to predict the occurrence of VTE in various types of lymphomas. In this study, we assess the clinical application of ThroLy RAM in a unified group of patients with diffuse large B-cell lymphoma (DLBCL). Methods Hospital databases were searched for patients with DLBCL and radiologically-confirmed VTE. Items in the ThroLy RAM, including prior VTE, reduced mobility, obesity, extranodal disease, mediastinal involvement, neutropenia and hemoglobin < 10.0 g/dL, were retrospectively reviewed. Results A total of 524 patients, median age 49 (range: 18-90) years were included. Patients had high disease burden; 57.3% with stage III/IV and 34.0% with bulky disease. All were treated on unified guidelines; 63 (12.0%) had primary refractory disease. Venous thromboembolic events were reported in 71 (13.5%) patients. Among 121 patients with high (> 3) ThroLy score, 22.3% developed VTE compared to 8.4% and 12.4% in those with low and intermediate risk scores, respectively ( P = .014). Simplifying the ThroLy model into two risk groups; high-risk (score ≥ 3) and low risk (score < 3) can still segregate patients; VTE developed in 44 (17.2%) high-risk patients ( n = 256) compared to 27 (10.1%) in the low-risk group ( n = 268), P = .038. Neutropenia, a component of the ThroLy, was encountered in only 14 (2.7%) patients. Conclusions ThroLy RAM can identify patients with DLBCL at high risk for VTE. Model can be modified by dividing patients into two, rather than three risk groups, and further simplified by omitting neutropenia.
Lenalidomide-induced arthritis: A case report and review of literature and pharmacovigilance databases
Authors: Icard Charlotte , Mocquot Pauline , Nogaro Jean-Claude , Despas Fabien , Gauthier Martin 
Published: September 2021

Introduction Lenalidomide is an immunomodulatory agent with multiple mechanisms of action, and treatment with lenalidomide is associated with adverse events such as thrombosis and abdominal pain; nonetheless, other rarer adverse events do exist, with few knowledge from physicians and pharmacists. For such adverse events, pharmacovigilance databases are of great interest. Case report A 71-year-old patient with no rheumatologic history, in complete remission of a mantle-cell lymphoma following rituximab, doxorubicin, vincristine, cyclophosphamide, and prednisone induction, received a maintenance treatment with rituximab and lenalidomide. After each course of lenalidomide and with no other new medication, the patient presented with fever and high inflammatory markers level, and a scapular-belt arthritis. Management and outcome The patient was managed with non-steroidal anti-inflammatory drugs and colchicine, with symptomatology and inflammation improvement. After discontinuation of lenalidomide, he had no arthritis relapse; it was then concluded that the patient had a lenalidomide-induced arthritis. We interrogated the national and international (VigiBase®) pharmacovigilance databases and found that arthritis in the context of lenalidomide exposure is a rare finding, with only three reported cases in France; 0.13% of adverse events reported with lenalidomide in the international database VigiBase® were arthritis. Discussion Our case then reports an uncommon finding, of which both pharmacists and physicians should be aware due to the wide and increasing use of lenalidomide.
Health professionals’ attitude and associated factors toward cytotoxic drug handling in University of Gondar specialized hospital: Institution-based cross-sectional study
Authors: Simegn Wudneh , Dagnew Baye , Dagne Henok , Weldegerima Berhanemeskel 
Published: September 2021

Background Studies have shown that cytotoxic drugs are dangerous to health care workers. Health care professionals’ attitude to cytotoxic drugs is vital to apply safety protocols in the prevention of cytotoxicity. The current study aimed to assess health professionals’ desirable attitude and associated factors toward cytotoxic drugs handling in the University of Gondar Specialized Hospital. Methods An institution-based cross-sectional study was conducted on 412 health professionals from June to August 2019. Simple random sampling was used to select participants and a self-administered questionnaire was used to collect data. Epi Info and SPSS 20 were used for data entry and analysis, respectively. Variables with a p value < 0.05 were declared as determinants. Results The number of health professionals included was approximately 412. The mean age of participants was 29.9 ± 5.4 years. The proportion of participants with desirable attitude toward cytotoxic drugs handling was 224 (54.4%) (95% confidence interval: 51.95–56.85). Male (adjusted odds ratio = 1.69, 95% confidence interval:[1.08–2.65]), work experience of 5–8 years (adjusted odds ratio = 1.92, 95% confidence interval: [1.10–3.34]), weekly working hours of 44–55 (adjusted odds ratio = 2.25, 95% confidence interval: [1.02–4.96]), medium work stress (adjusted odds ratio = 1.67, 95% confidence interval: [1.01–2.69]), and good practice of cytotoxic drug handling (adjusted odds ratio = 1.67, 95% confidence interval: [1.04–2.67]) were significantly associated with the attitude of health professionals. Conclusion A significant proportion of health care workers did not have desirable attitude to handle cytotoxic drugs. Thus, strategies are suggested to improve the positive attitude of health professionals to cytotoxic drug handling. Female health professionals, those who had work experience of less than 2 years and those with higher work stress demand special attention.