bluuebunny/crossref_metadata_2025_split huggingface dataset:
Signs of late infall and possible planet formation around DR Tau using VLT/SPHERE and LBTI/LMIRCam
Authors: Mesa D. , Ginski C. , Gratton R. , Ertel S. , Wagner K. , Bonavita M. , Fedele D. , Meyer M. , Henning T. , Langlois M. , Garufi A. , Antoniucci S. , Claudi R. , Defrère D. , Desidera S. , Janson M. , Pawellek N. , Rigliaco E. , Squicciarini V. , Zurlo A. , Boccaletti A. , Bonnefoy M. , Cantalloube F. , Chauvin G. , Feldt M. , Hagelberg J. , Hugot E. , Lagrange A.-M. , Lazzoni C. , Maurel D. , Perrot C. , Petit C. , Rouan D. , Vigan A. 
Published: November 2021

Context. Protoplanetary disks around young stars often contain substructures like rings, gaps, and spirals that could be caused by interactions between the disk and forming planets.
Aims. We aim to study the young (1–3 Myr) star DR Tau in the near-infrared and characterize its disk, which was previously resolved through submillimeter interferometry with ALMA, and to search for possible substellar companions embedded into it.
Methods. We observed DR Tau with VLT/SPHERE both in polarized light (H broad band) and total intensity (in Y, J, H, and K spectral bands). We also performed L′ band observations with LBTI/LMIRCam on the Large Binocular Telescope (LBT). We applied differential imaging techniques to analyze both the polarized data, using dual beam polarization imaging, and the total intensity data, using angular and spectral differential imaging.
Results. We found two previously undetected spirals extending north-east and south of the star, respectively. We further detected an arc-like structure north of the star. Finally a bright, compact and elongated structure was detected at a separation of 303 ± 10 mas and a position angle 21.2 ± 3.7 degrees, just at the root of the north-east spiral arm. Since this feature is visible both in polarized light and total intensity and has a blue spectrum, itis likely caused by stellar light scattered by dust.
Conclusions. The two spiral arms are at different separations from the star, have very different pitch angles, and are separated by an apparent discontinuity, suggesting they might have a different origin. The very open southern spiral arm might be caused by infalling material from late encounters with cloudlets into the formation environment of the star itself. The compact feature could be caused by interaction with a planet in formation still embedded in its dust envelope and it could be responsible for launching the north–east spiral. We estimate a mass of the putative embedded object of the order of few MJup.
Injecting Green Innovation Reporting into Sustainability Reporting
Authors: Khan Parvez Alam , Pritam Singh Satirenjit Kaur Johl , Johl Shireenjit Kaur , Shamim Amjad , Nurhayadi Yadi , Wijiharjono N. , Al-Azizah Ummu S. 
Published: November 2021

Reporting is a method for businesses to communicate with their various stakeholders. While the factors contributing to sustainability reporting and disclosure have been thoroughly investigated, the findings are inconclusive. Similarly, the non-financial reporting literature is disclosed of operational and non-operational activities related to ecological as well as social disclosure of firm. However, in recent years, stakeholders have increased their demand for green innovation practices (GIPs) to be included as a new component of ecological reporting. Thus, companies' proactivity in adopting green innovation reporting is reflected (GIR). This research propounds enhancing transparency in sustainability reporting by including corporations' GIPs, which will increase the transparency level of firm operations and instil greater stakeholder confidence. To accomplish this study, the legitimacy and signalling theories were used as an environmental solution.
Additionally, an exhaustive assessment of the literature was conducted in order to develop a GIR framework for enterprises to use when integrating GIPs into sustainability reporting. The outcome of this study indicates that current sustainability reporting takes a minimalist approach, with GIR being presented superficially. This non-financial reporting approach does not accurately reflect a company's genuine GIPs or the environmental effect of existing business operations. As such, this study calls for the integration of GIR into firms' sustainability reporting to accurately reflect their actual firm sustainable practices.
Langfristentwicklungen in der Kinder- und
Jugendrheumatologie
Authors: Haas Johannes-Peter , Minden Kirsten 
Published: November 2021

ZusammenfassungIm Gebiet der Kinderrheumatologie gab es in den letzten Jahrzehnten immense
Fortschritte, die sowohl die Diagnostik, als auch die Therapie nachhaltig
verbessert haben. Obwohl erst seit 2003 in Deutschland offiziell als
Zusatzbezeichnung anerkannt, stehen heutzutage über 200 Kinder- und
Jugendrheumatologen (d. h. 1,4 Kinderrheumatologen pro 100 000
Kinder) für die Erkennung und Behandlung von rheumatischen Erkrankungen
bei Kindern und Jugendlichen bundesweit zur Verfügung. Neue Erkenntnisse
in der Pathogenese rheumatischer Erkrankungen und die sich stetig
weiterentwickelnde genetische Diagnostik haben das rheumatische
Krankheitsspektrum und die Behandlungsmöglichkeiten dramatisch erweitert
Internationale Forschungsnetzwerke und eine spezielle Gesetzgebung für
die Entwicklung von pädiatrischen Medikamenten führten zur
Zulassung von zahlreichen neuen Rheumamedikamenten, deren Sicherheit im
klinischen Alltag seit der Jahrtausendwende systematisch in Deutschland
untersucht wird. Maßnahmen zur Sicherung der Versorgungsqualität
wurden implementiert, Standardinstrumente zur Bewertung der
Krankheitsaktivität und Krankheitslast aus Patientensicht
eingeführt sowie Initiativen zur Verbesserung der Versorgung Betroffener
(z. B. die ProKind-Initiative) auf den Weg gebracht. Diese
Veränderungen haben die Prognose und Lebensperspektive rheumakranker
Kinder und Jugendlicher verbessert, wenngleich noch weiterer Optimierungsbedarf
besteht.
Gefühlte und reale Arbeitsfähigkeit von
Patient*innen mit Post-COVID Symptomatik nach mildem Akutverlauf: eine
Analyse des Rehabilitation Needs Questionnaire (RehabNeQ)
Authors: Lemhöfer Christina , Best Norman , Gutenbrunner Christoph , Loudovici-Krug Dana , Teixido Lidia , Sturm Christian 
Published: November 2021

Zusammenfassung
Hintergrund Das Beschwerdebild der Folgeerscheinungen, die nach einer
COVID-19-Erkrankung auch nach Monaten existieren können, wird immer
deutlicher: das Post-COVID-Syndrom. Neben verschiedenen Symptomen können
auch funktionellen Zusammenhänge bestehen, die die
Arbeitsfähigkeit einschränken. Derzeitige Untersuchungen gehen
von 10% der Infizierten aus, die dies betrifft. In Deutschland
würde dies nach aktuellen Zahlen 380 000 Menschen betreffen. Das
Ziel dieser Analyse war es zu zeigen, wie sich die reale und gefühlte
Arbeitsfähigkeit bei Patient*innen mit Post-COVID Syndrom
darstellt.
Methode Der Rehabilitation Needs Questionnaire wird
routinemäßig bei Patient*innen mit
Post-COVID-Symptomatik bei Vorstellungen in der Medizinischen Hochschule
Hannover bzw. dem Universitätsklinikum Jena ausgefüllt. Es
erfolgte eine deskriptive Analyse der Fragebögen ab April 2021 unter
besonderer Berücksichtigung der Arbeitsfähigkeit. Ausgeschlossen
wurden Patient*innen, die nicht im arbeitsfähigen Alter waren,
oder bereits vor der COVID-19-Infektion arbeitsunfähig.
Ergebnisse 75 von 81 Fragebögen wurden im entsprechenden Zeitraum
von einer Stichprobe im arbeitsfähigen Alter in die Auswertung mit
einbezogen (68% von Frauen, 32% von Männern). Das
Durchschnittsalter lag bei 42,5 Jahren, die Zeit seit der Infektion im Mittel
bei 3 Monaten. 44 der 75 Personen (58,7%) waren zum Zeitpunkt der
Befragung arbeitsfähig. Die empfundene Arbeitsfähigkeit wurde im
Schnitt mit 5,1 von 10 möglichen Punkten angegeben. Frauen zeigten hier
durchschnittlich 6,2 Punkte und Männer 4,7 Punkte. 59,1%
(n=26) der Befragten gaben Schwierigkeiten beim Erhalt von notwendigen
Therapien an. 31 (41,3%) Personen waren zum Zeitpunkt der Befragung
aufgrund der POST-COVID-19-Erkrankung arbeitsunfähig. Das mittlere Alter
der Gruppe lag bei 46,6 Jahren. 16 (51,6%) der 31 Proband*innen
gaben an ununterbrochen seit der Infektion arbeitsunfähig zu sein.
Schwierigkeiten beim Erhalt von notwendigen Therapien hatten in dieser Gruppe
64,5% (n=20).
Diskussion Die Rate derer, die nach einer COVID-19-Erkrankung auch nach
Monaten noch arbeitsunfähig sind, ist hoch. Notwendige therapeutische
Maßnahmen stehen entweder in nicht genügender Anzahl zur
Verfügung oder werden trotz entsprechender Indikation nicht ausreichend
verordnet. Weitere Untersuchungen sind notwendig, um die Wirksamkeit von
Therapien zu belegen und welche Barrieren zur Rückkehr an den
Arbeitsplatz bestehen. Die Auswirkungen können bei weiter steigenden
Fallzahlen noch über Jahre hinweg Einfluss auf die Wirtschaftskraft des
Landes haben.
Therapeutic Effects of Azithromycin on Spinal Cord Injury in Male Wistar Rats: A Role for Inflammatory Pathways
Authors: Rismanbaf Ali , Afshari Khashayar , Ghasemi Mehdi , Badripour Abolfazl , Haj-Mirzaian Arvin , Dehpour Ahmad Reza , Shafaroodi Hamed 
Published: November 2021

Abstract
Background Inflammatory responses, including macrophages/microglia imbalance, are associated with spinal cord injury (SCI) complications. Accumulating evidence also suggests an anti-inflammatory property of azithromycin (AZM).
Material and Methods Male Wistar rats were subjected to T9 vertebra laminectomy. SCI was induced by spinal cord compression at this level with an aneurysmal clip for 60 seconds. They were divided into three groups: the sham-operated group and two SCI treatment (normal saline as a vehicle control vs. AZM at 180 mg/kg/d intraperitoneally for 3 days postsurgery; first dose: 30 minutes after surgery) groups. Locomotor scaling and behavioral tests for neuropathic pain were evaluated and compared through a 28-day period. At the end of the study, tissue samples were taken to assess neuroinflammatory changes and neural demyelination using ELISA and histopathologic examinations, respectively. In addition, the proportion of M1/M2 macrophage polarization was assessed by using flow cytometry.
Results Post-SCI AZM treatment (180 mg/kg/d for 3 days) significantly improved locomotion (p < 0.01) and decreased sensitivity to mechanical (p < 0.01) and thermal allodynia (p < 0.001). Moreover, there was a significant tumor necrosis factor-α (TNF-α) decline (p < 0.01) and interleukin-10 (IL-10) elevation (p < 0.01) in the spinal cord tissue of the AZM-treated group compared with the control groups 28 days post-SCI. AZM significantly improved neuroinflammation as evidenced by reduction of the M1 expression, elevation of M2 macrophages, and reduction of the M1/M2 ratio in both the dorsal root ganglion and the spinal cord tissue after SCI compared with controls (p < 0.01).
Conclusion AZM treatment can be considered a therapeutic agent for SCI, as it could reduce neuroinflammation and SCI sensory/locomotor complications.
Surviving a Self-inflicted Transorbital Pen Intrusion to the Cerebellum: Case Report
Authors: Breuskin David , Ketter Ralf , Oertel Joachim 
Published: November 2021

Abstract
Background Although intracranial traumas by penetrating foreign objects are not absolute rarities, the nature of trauma, the kind of object, and its trajectory make them a one of a kind case every time they occur. Whereas high-velocity traumas mostly result in fatalities, it is the low-velocity traumas that demand an individualized surgical strategy.
Methods We present a case report of a 33-year-old patient who was admitted to our department with a self-inflicted transorbital pen injury to the brain. The authors recall the incident and the technique of the pen removal.
Results Large surgical exposure of the pen trajectory was considered too traumatic. Therefore, we opted to remove the pen and have an immediate postoperative computed tomography (CT) scan. Due to its fragility, the pen case could only be removed with a screwdriver, inserted into the case. Post-op CT scan showed a small bleeding in the right peduncular region, which was treated conservatively. The patient was transferred back to intensive care unit and woken up the next day. She lost visual function on her right eye, but suffered from no further neurologic deficit.
Conclusion Surgical management of removal of intracranial foreign bodies is no routine procedure. Although some would favor a large surgical exposure, we could not think of an approach to do so without maximum surgical efforts. We opted for a minimal surgical procedure with immediate CT scan and achieved an optimal result. We find this case to be worth considering when deciding on a strategy in the future.
The Efficacy of Local Flaps in the Treatment of Traumatic Scalp Defects
Authors: Stepniewski Adam , Lehmann Wolfgang , Schilderoth Maximilian , Behringer Dominik , Emmerich Nadine , Daugardt Julian , von der Brelie Christian , Kauffmann Philipp , Felmerer Gunther 
Published: November 2021

Abstract
Background Scalp defects represent a therapeutic challenge. The aim of this study is to present our experience with local and regional flaps in the treatment of trauma-induced scalp defects. Furthermore, a comparison with other surgical techniques was performed.
Methods A retrospective evaluation of patient records was performed. Only patients who underwent surgery using local flaps between January 2010 and September 2020 due to traumatic scalp defects were included in the study.
Results In all, 10 cases were identified (3 females, 7 males, average age at surgery of 46.5 years [range: 18–82 years]). Six patients underwent surgery due to tissue defects and four due to scar keloids. Three patients experienced minor postoperative complications, one of which required additional surgery. The mean defect size was 35.75 cm2 (range: 4–79 cm2) among the four patients where the defect size could be determined retrospectively. The mean inpatient follow-up was 12.4 days (range: 2–34 days).
Conclusions Local flaps can be widely used. In carefully selected cases, they have the fewest disadvantages of all surgical techniques. In our experience, large angiosomes of the main scalp arteries allow the treatment of defects larger than 30 cm2 with local flaps. Our experience also suggests that the dimensions of flap length to flap width can exceed a ratio of 2:1 in the scalp.
Oral Iron Supplementation in Pregnancy: Current Recommendations and Evidence-Based Medicine
Authors: Duarte Ana Filipa Moreira , Carneiro Ana Catarina Simões Viana , Peixoto Ana Teresa Barbosa Maciel Meira , Montenegro Daniela Filipa Pereira , Campos Débora Sofia Carvalho , Alves Ana Patrícia Ribeiro , Costa Ana Rita Mota Magalhães , Fino Andreia Patrícia Machado 
Published: November 2021

Abstract
Objective To review the evidence about universal iron supplementation in pregnancy to prevent maternal anemia.
Methods Bibliographic research of randomized and controlled clinical trials, meta-analyses, systematic reviews, and clinical guidelines, published between August 2009 and August 2019, using the MeSH terms: iron; therapeutic use; pregnancy; anemia, prevention and control.
Results We included six clinical guidelines, three meta-analyses and one randomized controlled clinical trial.
Discussion Most articles point to the improvement of hematological parameters and reduction of maternal anemia risk, with supplementary iron. However, they do not correlate this improvement in pregnant women without previous anemia with the eventual improvement of clinical parameters.
Conclusion Universal iron supplementation in pregnancy is controversial, so we attribute a SORT C recommendation strength.
The Impact of the COVID-19 Pandemic on Depression and Sexual Function: Are Pregnant Women Affected More Adversely?
Authors: Denizli Ramazan , Sakin Önder , Koyuncu Kazibe , Çiçekli Nayif , Farisoğulları Nihat , Özdemir Mikail 
Published: November 2021

Abstract
Objective To investigate depression and sexual function among pregnant and non-pregnant women throughout the COVID-19 pandemic.
Methods A total of 188 women, 96 pregnant and 92 non-pregnant were included. The Beck Depression Inventory (BDI) and the Arizona Sexual Experience Scale (ASEX) were applied to the participants after obtaining sociodemographic data.
Results The depression scores of pregnant and non-pregnant women were similar (p = 0.846). We found that the depression scores were significantly higher among the group of participants who have lower economic status (p = 0.046). Moreover, the depression score was significantly higher among women who lost their income during the pandemic (p = 0.027). The score on the ASEX was significantly higher, and sexual dysfunction was more prevalent among women who have lower levels of schooling and income (p < 0.05). Likewise, the ASEX scores were significantly higher (p = 0.019) among the group who experienced greater income loss throughout the pandemic. Upon comparing the pregnant and non-pregnant groups, we detected that sexual dysfunction had a significantly higher rate among pregnant women (p < 0.001).
Conclusion In times of global crisis, such as the current pandemic, low-income families have an increased risk of experiencing depression and sexual dysfunction. When we compared pregnant women with non-pregnant women, depression scores were similar, but pregnant women were at a 6.2 times higher risk of developing sexual dysfunction.
A Policy Framework to Support Shared Decision-Making through the Use of Person-Generated Health Data
Authors: Petersen Carolyn , Edmunds Margo , McGraw Deven , Priest Elisa L. , Smith Jeffery R.L. , Kemp Eagan , Campos Hugo 
Published: November 2021

Abstract
Background Individuals increasingly want to access, contribute to, and share their personal health information to improve outcomes, such as through shared decision-making (SDM) with their care teams. Health systems' growing capacity to use person-generated health data (PGHD) expands the opportunities for SDM. However, SDM not only lacks organizational and information infrastructure support but also is actively undermined, despite public interest in it.
Objectives This work sought to identify challenges to individual–clinician SDM and policy changes needed to mitigate barriers to SDM.
Methods Two multi-stakeholder group of consumers, patients, caregivers; health services researchers; and experts in health policy, informatics, social media, and user experience used a consensus process based on Bardach's policy analysis framework to identify barriers to SDM and develop recommendations to reduce these barriers.
Results Technical, legal, organizational, cultural, and logistical obstacles make data sharing difficult, thereby undermining use of PGHD and realization of SDM. Stronger privacy, security, and ethical protections, including informed consent; promoting better consumer access to their data; and easier donation of personal data for research are the most crucial policy changes needed to facilitate an environment that supports SDM.
Conclusion Data protection policy lags far behind the technical capacity for third parties to share and reuse electronic information without appropriate permissions, while individuals' right to access their own health information is often restricted unnecessarily, poorly understood, and poorly communicated. Sharing of personal information in a private, secure environment in which data are shared only with individuals' knowledge and consent can be achieved through policy changes.
Adjusting Insert Thickness and Tibial Slope Do Not Correct Internal Tibial Rotation Loss Caused by PCL Resection: In Vitro Study of a Medial Constraint TKA Implanted with Unrestricted Calipered Kinematic Alignment
Authors: Nedopil Alexander J. , Thadani Peter J. , McCoy Thomas H. , Howell Stephen M. , Hull Maury L. 
Published: November 2021

AbstractMost medial stabilized (MS) total knee arthroplasty (TKA) implants recommend excision of the posterior cruciate ligament (PCL), which eliminates the ligament's tension effect on the tibia that drives tibial rotation and compromises passive internal tibial rotation in flexion. Whether increasing the insert thickness and reducing the posterior tibial slope corrects the loss of rotation without extension loss and undesirable anterior lift-off of the insert is unknown. In 10 fresh-frozen cadaveric knees, an MS design with a medial ball-in-socket (i.e., spherical joint) and lateral flat insert was implanted with unrestricted calipered kinematic alignment (KA) and PCL retention. Trial inserts with goniometric markings measured the internal–external orientation relative to the femoral component's medial condyle at maximum extension and 90 degrees of flexion. After PCL excision, these measurements were repeated with the same insert, a 1 mm thicker insert, and a 2- and 4-mm shim under the posterior tibial baseplate to reduce the tibial slope. Internal tibial rotation from maximum extension and 90 degrees of flexion was 15 degrees with PCL retention and 7 degrees with PCL excision (p < 0.000). With a 1 mm thicker insert, internal rotation was 8 degrees (p < 0.000), and four TKAs lost extension. With a 2 mm shim, internal rotation was 9 degrees (p = 0.001) and two TKAs lost extension. With a 4 mm shim, internal rotation was 10 degrees (p = 0.002) and five TKAs lost extension and three had anterior lift-off. The methods of inserting a 1 mm thicker insert and reducing the posterior slope did not correct the loss of internal tibial rotation after PCL excision and caused extension loss and anterior lift-off in several knees. PCL retention should be considered when using unrestricted calipered KA and implanting a medial ball-in-socket and lateral flat insert TKA design, so the progression of internal tibial rotation and coupled reduction in Q-angle throughout flexion matches the native knee, optimizing the retinacular ligaments' tension and patellofemoral tracking.
The Current Role of Induced Endometrial Trauma (Endometrial Scratch) in Women Undergoing Infertility Treatment
Authors: Metwally Mostafa , Walters Stephen , Chatters Robin 
Published: November 2021

AbstractInduced endometrial trauma, otherwise known as endometrial scratch is a simple technique that has been rapidly adopted into clinical practice, mainly for women having IVF treatment, in an attempt to increase pregnancy rates. The introduction of endometrial scratch followed early reports of improved clinical pregnancy rates in women with repetitive implantation failure after having the procedure and follows on from evidence from animal models in the early 20th century suggesting that mechanical trauma to the endometrium can induce decidual changes. Due to the ease and low cost of the procedure, it has been rapidly adopted as an add-on to fertility treatments, in many cases where evidence is still lacking. Despite the initial publication of a large number of studies that demonstrated encouraging improvements in pregnancy rates in women who underwent this procedure, these studies were mainly limited by the small sample sizes and heterogeneity of their study populations, leading to limited validity of the evidence provided by these studies. More recently, three large randomized controlled studies have been published that paint a different picture regarding the value of this procedure. This article explores the evolution of the evidence and the current state of endometrial scratch as an adjuvant therapy for women undergoing IVF treatment.