bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Model Latihan Kebugaran Jasmani Berbasis Permainan Tradisional Sebagai Aktivitas Belajar Siswa Dalam Pembelajaran PJOK
Authors: Bile Robertus Lili , Tapo Yohanes Bayo Ola , Desi Avelina Kurniati 
Published: October 2021

Inovasi pembelajaran penjas yang efektif dan menyenangkan perlu dilakukan secara berkala agar menambah alternatif model pembelajaran yang dapat memacu peningkatan motivasi belajar siswa. Penelitian ini merupakan jenis penelitian dan pengembangan yang bertujuan untuk: (1) mengembangkan model latihan kebugaran jasmani berbasis permainan tradisional, (2) menguji kelayakan penggunaan produk pengembangan. Desain penelitian meliputi (1) penelitian produk yang telah ada, (2) perencanaan pengembangan produk, (3) Pengujian internal desain tahap I, (4) revisi produk I, (5) pengujian internal desain tahap II, (6) revisi produk II, (7) produk akhir. Tempat dan subyek penelitian yaitu siswa SMP Citra Bakti berjumlah 9 orang. Data penelitian dikumpulkan menggunakan angket skala nilai. Analisis data menggunakan teknik analisis deskriptif kualitatif dan kuantitatif. Hasil penelitian adalah (1) model latihan kebugaran jasmani berbasis permainan tradisional sebagai aktivitas belajar siswa yang diberi nama Model Latihan Play4Fit. (2) model latihan kebugaran jasmani berbasis permainan tradisional (Play4Fit) memenuhi kategori “sesuai” (layak) digunakan sebagai bentuk aktivitas belajar siswa pada materi latihan kebugaran jasmani dalam pembelajaran penjas.
Qualitative findings from a Housing First evaluation project for homeless Veterans in Canada
Authors: Forchuk Cheryl , Richardson Jan , Atyeo Heather , Serrato Jonathan 
Published: October 2021

LAY SUMMARY This two-year study implemented a Housing First approach among homelessness services for Veterans in four cities across Canada (Victoria, Calgary, London, and Toronto). This approach included peer support and harm reduction resources for Veterans. To obtain a detailed evaluation of personal experiences and opinions, focus groups were held with Veterans, housing staff, and stakeholders at three time points during the study: July-September 2012, May-June 2013, and January 2014. Harm reduction and peer support were regarded as positive aspects of this new approach to housing and homelessness. It was suggested that greater mental health support, support from peers with military experience, and issues regarding roommates should be considered in future implementations of housing services for Veterans. It was also noted that to support personal stabilization, permanent housing is preferred over transitional or temporary housing. Future housing programs serving Veterans experiencing homelessness should consider the addition of harm reduction and peer support to further enhance services and help maintain housing stability.
Analysis of the Electronic Implementation of A Malaria Surveillance Information System (E-SISMAL) in the Lahat District
Authors: Nuraini Eni , Hasyim Hamzah , Idris Haerawati , Ghiffari Ahmad , Chairil Anwar  
Published: October 2021

Background: The requirement for malaria elimination to be recognized is to prove API lower than 1 per 1000 in the population, together with no indigenous case. Lahat Regency is an area of low-endemicity for malaria, where the target for elimination is projected for 2024. Since 2019, Lahat Regency has received socialization about E-SISMAL, which was developed as a web-based basis to speed up the reporting process. However, there are still delays in reporting malaria on E-SISMAL.
Methods: Descriptive research with a qualitative approach was designed. The study subjects were the malaria person in charge, the head of seven selected community health centers (Puskesmas) and the Lahat District Health Office. Primary data came from observation, focus group discussion (FGD) and in-depth interviews with eighteen informants selected by the purposive sampling method.
Results: The available inputs are inadequate, such as the human resource education was not up to standard, the internet network was not smooth, and there were no guidelines on E-SISMAL in the health centers. Malaria person in charge does not understand how to use E-SISMAL. In the process, there was the involvement of cross-sectoral and networked establishments. The output shows that the report indicators on E-SISMAL are not up to standard with less than 80%.
Conclusions: The use of E-SISMAL in the Lahat district has not been maximized. It has an impact on delays in reporting. It is recommended that training and practice of E-SISMAL occur to improve officers' ability through socialization and that the Lahat Health Office establishes partnerships with telecommunications companies to ensure the smooth running of the network. Developing specific guidelines on E-SISMAL and a mobile phone-based malaria surveillance information system to speed up the malaria reporting process in the Lahat district is also advisable.
Metagenomic Analysis of Dental Plaque on Pit and Fissure Sites With and Without Caries Among Adolescents
Authors: Pang Liangyue , Wang Yinuo , Ye Yun , Zhou Yan , Zhi Qinghui , Lin Huancai 
Published: October 2021

Caries is one of the most prevalent infectious diseases worldwide and is driven by the dysbiosis of dental biofilms adhering to tooth surfaces. The pits and fissured surfaces are the most susceptible sites of caries. However, information on the taxonomic composition and functional characteristics of the plaque microbiota in the pit and fissure sites is very limited. This study aimed to use metagenomic sequencing analyses to investigate the relationship between the plaque microbiome in the pit and fissure site and caries in adolescents. A total of 20 adolescents with active pit and fissure surface caries were involved as well as 20 age-matched, caries-free teenagers for control tests. Plaque samples were collected from the pit and fissure site and were subjected to metagenomic analyses, in which the microbial communities were investigated. Our results showed that the microbiota diversity was similar between those two groups. At the species level, the relative abundances of A. gerencseriae, P. acidifaciens, P. multisaccharivorax, S. oralis, S. mutans, and P. denticolens were higher in the caries-active group. N. elongata, C. hominis, and A. johnsonii were relatively more abundant in the caries-free groups. Functional analysis suggested that the metabolic pathway was the most abundant pathway, and the functional traits of the level 2 pathways included amino acid metabolism, metabolism of cofactors, and vitamins and carbohydrate metabolism. Our results also revealed that the caries group displayed several alterations in metabolic pathways, including enriched functions in carbohydrate digestion and absorption. This study suggested that in addition to the specific anatomical structures of the pit and fissured surfaces, the fundamental differences in the plaque microbiome may also be related to the susceptibility of pit and fissure caries.
Evaluation of the MGISEQ-2000 Sequencing Platform for Illumina Target Capture Sequencing Libraries
Authors: Lang Jidong , Zhu Rongrong , Sun Xue , Zhu Siyu , Li Tianbao , Shi Xiaoli , Sun Yanqi , Yang Zhou , Wang Weiwei , Bing Pingping , He Binsheng , Tian Geng 
Published: October 2021

Illumina is the leading sequencing platform in the next-generation sequencing (NGS) market globally. In recent years, MGI Tech has presented a series of new sequencers, including DNBSEQ-T7, MGISEQ-2000 and MGISEQ-200. As a complex application of NGS, cancer-detecting panels pose increasing demands for the high accuracy and sensitivity of sequencing and data analysis. In this study, we used the same capture DNA libraries constructed based on the Illumina protocol to evaluate the performance of the Illumina Nextseq500 and MGISEQ-2000 sequencing platforms. We found that the two platforms had high consistency in the results of hotspot mutation analysis; more importantly, we found that there was a significant loss of fragments in the 101–133 bp size range on the MGISEQ-2000 sequencing platform for Illumina libraries, but not for the capture DNA libraries prepared based on the MGISEQ protocol. This phenomenon may indicate fragment selection or low fragment ligation efficiency during the DNA circularization step, which is a unique step of the MGISEQ-2000 sequence platform. In conclusion, these different sequencing libraries and corresponding sequencing platforms are compatible with each other, but protocol and platform selection need to be carefully evaluated in combination with research purpose.
Prospective Evaluation of the Association Between Arthritis and Cognitive Functions in Middle-Aged and Elderly Chinese
Authors: Liu Wenyu , Yang Xue , Jin Xingzhong , Xiu Peng , Wen Ying , Wu Nianwei , Zhao Jian , Zhou Dong , Pan Xiong-Fei 
Published: October 2021

Background: Assessing the relation between arthritis and cognitive impairment could expand the understanding of health consequences of arthritis. The aim was to prospectively examine the association between arthritis and cognitive functions among middle-aged and elderly Chinese.Methods: Our analyses were based on data from the nationwide China Health and Retirement Longitudinal Study (2011–2016). Arthritis was ascertained by self-reported doctor diagnosis during the baseline survey. Cognitive functions were evaluated in three domains including episodic memory, mental status, and global cognition. Linear mixed models were employed to assess the association between baseline arthritis and cognition functions.Results: Of 7,529 Chinese adults, 49.79% were men, and mean age was 57.53 years. During a follow-up of 4 years, participants with baseline arthritis showed lower scores of episodic memory [β = −0.08; 95% confidence interval (CI): −0.14, −0.03], mental status (β = −0.14; 95% CI: −0.22, −0.05), and global cognition (β = −0.22; 95% CI: −0.34, −0.11), compared to those without arthritis. In addition, participants with arthritis showed increased rates of decline in mental status and global cognition by 0.04 (95% CI: 0.01, 0.08) and 0.05 (95% CI: 0.01, 0.09) units per year, respectively.Conclusion: Arthritis was associated with subsequent risk of poorer cognitive functions and slightly faster declines in cognitive functions among Chinese middle-aged and elderly adults. Our findings should be confirmed in future large prospective studies in Chinese and other populations.
Reorganization of Brain Functional Connectivity Network and Vision Restoration Following Combined tACS-tDCS Treatment After Occipital Stroke
Authors: Xu Jiahua , Wu Zheng , Nürnberger Andreas , Sabel Bernhard A. 
Published: October 2021

Objective: Non-invasive brain stimulation (NIBS) is already known to improve visual field functions in patients with optic nerve damage and partially restores the organization of brain functional connectivity networks (FCNs). However, because little is known if NIBS is effective also following brain damage, we now studied the correlation between visual field recovery and FCN reorganization in patients with stroke of the central visual pathway.Method: In a controlled, exploratory trial, 24 patients with hemianopia were randomly assigned to one of three brain stimulation groups: transcranial direct current stimulation (tDCS)/transcranial alternating current stimulation (tACS) (ACDC); sham tDCS/tACS (AC); sham tDCS/sham tACS (Sham), which were compared to age-matched controls (n = 24). Resting-state electroencephalogram (EEG) was collected at baseline, after 10 days stimulation and at 2 months follow-up. EEG recordings were analyzed for FCN measures using graph theory parameters, and FCN small worldness of the network and long pairwise coherence parameter alterations were then correlated with visual field performance.Result: ACDC enhanced alpha-band FCN strength in the superior occipital lobe of the lesioned hemisphere at follow-up. A negative correlation (r = −0.80) was found between the intact visual field size and characteristic path length (CPL) after ACDC with a trend of decreased alpha-band centrality of the intact middle occipital cortex. ACDC also significantly decreased delta band coherence between the lesion and the intact occipital lobe, and coherence was enhanced between occipital and temporal lobe of the intact hemisphere in the low beta band. Responders showed significantly higher strength in the low alpha band at follow-up in the intact lingual and calcarine cortex and in the superior occipital region of the lesioned hemisphere.Conclusion: While ACDC decreases delta band coherence between intact and damaged occipital brain areas indicating inhibition of low-frequency neural oscillations, ACDC increases FCN connectivity between the occipital and temporal lobe in the intact hemisphere. When taken together with the lower global clustering coefficient in responders, these findings suggest that FCN reorganization (here induced by NIBS) is adaptive in stroke. It leads to greater efficiency of neural processing, where the FCN requires fewer connections for visual processing.
Neurophysiological Examinations as Adjunctive Tool to Imaging Techniques in Spontaneous Intracerebral Hemorrhage: IRONHEART Study
Authors: Fekete Klára , Tóth Judit , Horváth László , Márton Sándor , Héja Máté , Csiba László , Árokszállási Tamás , Bagoly Zsuzsa , Sulina Dóra , Fekete István 
Published: October 2021

Introduction: Intracerebral hemorrhage (ICH) is a devastating disease, which may lead to severe disability or even death. Although many factors may influence the outcome, neurophysiological examinations might also play a role in its course. Our aim was to examine whether the findings of electroencephalography (EEG) and transcranial magnetic stimulation (TMS) can predict the prognosis of these patients.Methods: Between June 1 2017 and June 15 2021, 116 consecutive patients with ICH were enrolled prospectively in our observational study. Clinical examinations and non-Contrast computed tomography (NCCT) scan were done on admission for ICH; follow-up NCCT scans were taken at 14 ± 2 days and at 3 months ± 7 days after stroke onset. EEG and TMS examinations were also carried out.Results: Of the patients in the study, 65.5% were male, and the mean age of the study population was 70 years. Most patients had a history of hypertension, 50.8% of whom had been untreated. In almost 20% of the cases, excessive hypertension was measured on admission, accompanied with &gt;10 mmol/L blood glucose level, whereas their Glasgow Coma Scale was 12 on average. Presence of blood in the ventricles or subarachnoid space and high blood and perihematomal volumes meant poor prognosis. Pathological EEG was prognostic of a worse outcome. With TMS examination at 14 days, it might be possible to estimate outcome in a univariate model and the absence, or reduction of the amplitude of the motor evoked potentials was associated with poor prognosis.Conclusion: Together with the clinical symptoms, the volume of bleeding, perihematomal edema (or their combined volume), and neurophysiological examinations like EEG and TMS play an important role in the neurological outcome of patients with ICH. This might affect the patients' rehabilitation plans in the future, since with the help of the examinations the subset of patients with potential for recovery could be identified.
Assessment of Food Supplement Consumption in Polish Population of Adults
Authors: Stoś Katarzyna , Woźniak Agnieszka , Rychlik Ewa , Ziółkowska Izabela , Głowala Aneta , Ołtarzewski Maciej 
Published: October 2021

Introduction: In recent years, there has been a great interest in food supplements. However the use of food supplements can be associated with the risk of excessive intake of vitamins or minerals which may have adverse health effects.Objective: Assessment of food supplement consumption in the adult population in Poland.Materials and Methods: The study was conducted on 1,831 adults (913 men, 918 women) from which 178 (59 men, 119 women) food supplement users were selected. The consumption of food supplements were assessed by the 24-h recall repeated two times and the food propensity questionnaire (FPQ).Results: 10% of the subjects consumed food supplements during the 12 months prior to the study (6% of men, 13% of women) and among users 68% (79% of men and 88% of women) in the day before the survey. Most respondents (44%) used vitamin supplements during the year. More men than women (27 vs. 11%, p = 0.0059) used mineral supplements while more women than men used vitamin and mineral supplements (31 vs. 8%, p = 0.0008). The most frequently supplemented vitamins were: B6 (58%), C (53%), and D (47%) and minerals were: magnesium (43%), zinc (34%), and iron (29%). More women than men supplemented vitamin B6 (71 vs. 40%, p = 0.0012), vitamin D (54 vs. 36%, p = 0.0061) and magnesium (49 vs. 34%, p = 0.0075). Intake of riboflavin, pantothenic acid and manganese were higher in the group of men (respectively: 3.3 mg ± 6.0 vs. 1.4 mg ± 0.3, p = 0.0329; 9.4 mg ± 5.6 vs. 6.1 mg ± 2.0, p = 0.0357; 2.2 mg ± 0.9 vs. 1.3 mg ± 0.6, p = 0.0080) but intake of vitamin D was higher in the group of women (15.7 μg ± 20.4 vs. 33.1 μg ± 26.4, p = 0.0085). In many cases, the intake of vitamins and minerals from food supplements covered the Dietary Reference Values for these nutrients in 100%. In some persons the intake of biotin, vitamin B12, C, B6, riboflavin, niacin was higher than the reference values several dozen times. The intake of vitamins and minerals exceed UL in a few cases relating to vitamin B6 and magnesium.Conclusions: A minority of adults in Poland used food supplements. However, those products were a significant source of vitamins and minerals. Intake of vitamins and minerals from food supplements should be monitored.
College Students' Perception of Snacks Sold in Vending Machines in the US: A Mixed-Methods Study
Authors: Mengarelli Cristiana Assumpção , Kirchoff Christie , Palacios Cristina 
Published: October 2021

Introduction: Food in vending machines in US colleges contain limited nutritious foods available for purchase, which could affect the food choices made by students leading to poor diet quality. Interventions to improve college foodscapes usually follow a top-down approach and fail to affect dietary behavioral changes ultimately. This research aims to uncover what students want and ways to achieve change.Methods: The mixed-methods approach included peer-led qualitative focus group discussions and a brief quantitative questionnaire on satisfaction from foods available in vending machines. A convenience sample of 20 students (15 females) was recruited from a Hispanic serving institution for this study.Results: Vending machines were perceived as convenient, plentiful, and unhealthy. Students expressed dissatisfaction with both the variety and nutritional quality of snacks in vending machines. Suggestions for improvement included more fresh items (fruits and vegetables) and refrigerated items with higher protein content (low-fat yogurt, hummus, and peanut butter). To implement these improvements, participants discussed the cost and feasibility of perishable items. Increasing awareness and partnering strategies were proposed to mediate potential cost and buy-in obstacles as was elevating the appeal of healthy vending machines with technological enhancements that draw customers in and educate.Conclusion and Implication for Practice: This group of college students was eager for positive changes in foods sold in vending machines and understand the major difficulties. The suggested changes may help this and other colleges develop policies to regulate the foods in vending machines to promote overall health and help prevent chronic diseases in the future.
Can Ketogenic Diet Improve Alzheimer's Disease? Association With Anxiety, Depression, and Glutamate System
Authors: de la Rubia Ortí Jose Enrique , Fernández David , Platero Félix , García-Pardo María Pilar 
Published: October 2021

Background: Alzheimer's disease is the most common neurodegenerative disorder in our society, mainly characterized by loss of cognitive function. However, other symptoms such as anxiety and depression have been described in patients. The process is mediated by alterations in the synaptic and extrasynaptic activity of the neurotransmitter glutamate, which are linked to a hypometabolism of glucose as the main source of brain energy. In that respect, Ketogenic diet (KD) has been proposed as a non-pharmacological treatment serving as an alternative energy source to the neurons increasing the fat percentage and reducing the carbohydrates percentage, showing promising results to improve the cognitive symptoms associated with different neurodegenerative disorders, including AD. However, the association of this type of diet with emotional symptoms and the modulation of glutamate neurotransmission systems after this dietary reduction of carbohydrates are unknown.Objective: The aim of this short review is to provide update studies and discuss about the relationship between KD, anxiety, depression, and glutamate activity in AD patients.Discussion: The main results suggest that the KD is an alternative energy source for neurons in AD with positive consequences for the brain at different levels such as epigenetic, metabolic and signaling, and that the substitution of carbohydrates for fats is also associated with emotional symptoms and glutamate activity in AD.
Laparoscopic Pancreaticoduodenectomy Versus Conventional Open Approach for Patients With Pancreatic Duct Adenocarcinoma: An Up-to-Date Systematic Review and Meta-Analysis
Authors: Feng Qingbo , Liao Wenwei , Xin Zechang , Jin Hongyu , Du Jinpeng , Cai Yunshi , Liao Mingheng , Yuan Kefei , Zeng Yong 
Published: October 2021

BackgroundTo compare perioperative and oncological outcomes of pancreatic duct adenocarcinoma (PDAC) after laparoscopic versus open pancreaticoduodenectomy (LPD vs. OPD), we performed a meta-analysis of currently available propensity score matching studies and large-scale retrospective cohorts to compare the safety and overall effect of LPD to OPD for patients with PDAC.MethodsA meta-analysis was registered at PROSPERO and the registration number is CRD42021250395. PubMed, Web of Science, EMBASE, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov databases were searched based on a defined search strategy to identify eligible studies before March 2021. Data on operative times, blood loss, 30-day mortality, reoperation, length of hospital stay (LOS), overall morbidity, Clavien–Dindo ≥3 complications, postoperative pancreatic fistula (POPF), blood transfusion, delayed gastric emptying (DGE), postpancreatectomy hemorrhage (PPH), and oncologic outcomes (R0 resection, lymph node dissection, overall survival, and long-term survival) were subjected to meta-analysis.ResultsOverall, we identified 10 retrospective studies enrolling a total of 11,535 patients (1,514 and 10,021 patients underwent LPD and OPD, respectively). The present meta-analysis showed that there were no significant differences in overall survival time, 1-year survival, 2-year survival, 30-day mortality, Clavien-Dindo ≥3 complications, POPF, DGE, PPH, and lymph node dissection between the LPD and OPD groups. Nevertheless, compared with the OPD group, LPD resulted in significantly higher rate of R0 resection (OR: 1.22; 95% CI 1.06–1.40; p = 0.005), longer operative time (WMD: 60.01 min; 95% CI 23.23–96.79; p = 0.001), lower Clavien–Dindo grade ≥III rate (p = 0.02), less blood loss (WMD: −96.49 ml; 95% CI −165.14 to −27.83; p = 0.006), lower overall morbidity rate (OR: 0.65; 95% CI 0.50 to 0.85; p = 0.002), shorter LOS (MD = −2.73; 95% CI −4.44 to −1.03; p = 0.002), higher 4-year survival time (p = 0.04), 5-year survival time (p = 0.001), and earlier time to starting adjuvant chemotherapy after surgery (OR: −10.86; 95% CI −19.42 to −2.30; p = 0.01).ConclusionsLPD is a safe and feasible alternative to OPD for patients with PDAC, and compared with OPD, LPD seemed to provide a similar OS.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/#recordDetails.