bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective comparison of the diagnostic accuracy of 18F-FDG PET/MRI, MRI, CT, and bone scintigraphy for the detection of bone metastases in the initial staging of primary breast cancer patients
Authors: Bruckmann Nils Martin , Kirchner Julian , Umutlu Lale , Fendler Wolfgang Peter , Seifert Robert , Herrmann Ken , Bittner Ann-Kathrin , Hoffmann Oliver , Mohrmann Svjetlana , Antke Christina , Schimmöller Lars , Ingenwerth Marc , Breuckmann Katharina , Stang Andreas , Buchbender Christian , Antoch Gerald , Sawicki Lino M. 
Published: April 2021

Abstract
Objectives
To compare the diagnostic performance of [18F]FDG PET/MRI, MRI, CT, and bone scintigraphy for the detection of bone metastases in the initial staging of primary breast cancer patients.

Material and methods
A cohort of 154 therapy-naive patients with newly diagnosed, histopathologically proven breast cancer was enrolled in this study prospectively. All patients underwent a whole-body [18F]FDG PET/MRI, computed tomography (CT) scan, and a bone scintigraphy prior to therapy. All datasets were evaluated regarding the presence of bone metastases. McNemar χ2 test was performed to compare sensitivity and specificity between the modalities.

Results
Forty-one bone metastases were present in 7/154 patients (4.5%). Both [18F]FDG PET/MRI and MRI alone were able to detect all of the patients with histopathologically proven bone metastases (sensitivity 100%; specificity 100%) and did not miss any of the 41 malignant lesions (sensitivity 100%). CT detected 5/7 patients (sensitivity 71.4%; specificity 98.6%) and 23/41 lesions (sensitivity 56.1%). Bone scintigraphy detected only 2/7 patients (sensitivity 28.6%) and 15/41 lesions (sensitivity 36.6%). Furthermore, CT and scintigraphy led to false-positive findings of bone metastases in 2 patients and in 1 patient, respectively. The sensitivity of PET/MRI and MRI alone was significantly better compared with CT (p < 0.01, difference 43.9%) and bone scintigraphy (p < 0.01, difference 63.4%).

Conclusion
[18F]FDG PET/MRI and MRI are significantly better than CT or bone scintigraphy for the detection of bone metastases in patients with newly diagnosed breast cancer. Both CT and bone scintigraphy show a substantially limited sensitivity in detection of bone metastases.

Key Points
• [18F]FDG PET/MRI and MRI alone are significantly superior to CT and bone scintigraphy for the detection of bone metastases in patients with newly diagnosed breast cancer.
• Radiation-free whole-body MRI might serve as modality of choice in detection of bone metastases in breast cancer patients.
A systematic review about long-term results after meniscus repair
Authors: Petersen Wolf , Karpinski Katrin , Bierke Sebastian , Müller Rath Ralf , Häner Martin 
Published: April 2021

Abstract
Purpose
Aim of this systematic review was to analyze long-term results after meniscus refixation.

Methods
A systematic literature search was carried out in various databases on studies on long-term results after meniscus refixation with a minimum follow-up of 7 years. Primary outcome criterion was the failure rate. Secondary outcome criteria were radiological signs of osteoarthritis (OA) and clinical scores.

Results
A total of 12 retrospective case series (level 4 evidence) were identified that reported about failure rates of more than 7 years follow-up. There was no statistical difference in the failure rates between open repair, arthroscopic inside-out with posterior incisions and arthroscopic all-inside repair with flexible non-resorbable implants. In long-term studies that examined meniscal repair in children and adolescents, failure rates were significantly higher than in studies that examined adults. Six studies have shown minor radiological degenerative changes that differ little from the opposite side. The reported clinical scores at follow-up were good to very good.

Conclusion
This systematic review demonstrates that good long-term outcomes can be obtained in patients after isolated meniscal repair and in combination with ACL reconstruction. With regard to the chondroprotective effect of meniscus repair, the long-term failure rate is acceptable.

Level of evidence
IV.
The Relationships Between Radiation Dosage and Long-term Swallowing Kinematics and Timing in Nasopharyngeal Carcinoma Survivors
Authors: Pu Dai , Lee Victor H. F. , Chan Karen M. K. , Yuen Margaret T. Y. , Quon Harry , Tsang Raymond K. Y. 
Published: April 2021

AbstractThis study aimed to investigate the relationship between intensity-modulated radiation therapy (IMRT) dosimetry and swallowing kinematic and timing measures. Thirteen kinematic and timing measures of swallowing from videofluoroscopic analysis were used as outcome measures to reflect swallowing function. IMRT dosimetry was accessed for thirteen swallowing-related structures. A cohort of 44 nasopharyngeal carcinoma (NPC) survivors at least 3 years post-IMRT were recruited. The cohort had a mean age of 53.2 ± 11.9 years, 77.3% of whom were male. There was an average of 68.24 ± 14.15 months since end of IMRT; 41 (93.2%) had undergone concurrent chemotherapy. For displacement measures, female sex and higher doses to the cricopharyngeus, glottic larynx, and base of tongue were associated with reduced hyolaryngeal excursion and pharyngeal constriction, and more residue. For timing measures, higher dose to the genioglossus was associated with reduced processing time at all stages of the swallow. The inferior pharyngeal constrictor emerged with a distinctly different pattern of association with mean radiation dosage compared to other structures. Greater changes to swallowing kinematics and timing were observed for pudding thick consistency than thin liquid. Increasing radiation dosage to swallowing-related structures is associated with reduced swallowing kinematics. However, not all structures are affected the same way, therefore organ sparing during treatment planning for IMRT needs to consider function rather than focusing on select muscles. Dose-response relationships should be investigated with a comprehensive set of swallowing structures to capture the holistic process of swallowing.
Was kann das Konzept der Diskriminierung für die Medizinethik leisten? – Eine Analyse
Authors: Hädicke Maximiliane , Wiesemann Claudia 
Published: April 2021

ZusammenfassungKaum ein Begriff der ethischen Debatten der letzten Jahre hat eine solche Konjunktur erlebt wie der Begriff der Diskriminierung. Eine vergleichende Erörterung des Konzepts einschließlich seiner begrifflichen Nuancen und seiner ethischen Bedeutung für das Gesundheitswesen fehlte jedoch bislang. Ziel dieses Beitrags ist die Entwicklung eines differenzierten Verständnisses von Diskriminierung auf der Basis der philosophischen und soziologischen Literatur vor dem Hintergrund ethisch relevanter medizinischer und pflegerischer Szenarios. Anhand von praktischen Beispielen aus dem Gesundheitswesen erörtern wir die Besonderheiten direkter, indirekter und statistischer Diskriminierung, wir untersuchen die Bedeutung von Absichten und die Rolle von kollektiven Akteuren. Zudem diskutieren wir, welche sozialen Gruppen diskriminiert werden können und welche Rolle Formen epistemischer Ungerechtigkeit dabei spielen. Argumentiert wird, dass das Konzept trotz seiner Komplexität einen signifikanten Mehrwert bietet, weil es erlaubt, Formen der Benachteiligung aufzuzeigen, die über die Verletzung einzelner spezifischer Rechte oder Interessen hinausgehen. Als wissensbasiertes System von großem gesellschaftlichen Einfluss weist das Gesundheitswesen einige Eigenschaften auf, die Diskriminierung begünstigen können. Dies zu erkennen ist unerlässlich, um Diskriminierung wirksam entgegentreten zu können.
Integrated economic and environmental building classification and optimal seismic vulnerability/energy efficiency retrofitting
Authors: Caruso Martina , Pinho Rui , Bianchi Federica , Cavalieri Francesco , Lemmo Maria Teresa 
Published: April 2021

AbstractA life cycle framework for a new integrated classification system for buildings and the identification of renovation strategies that lead to an optimal balance between reduction of seismic vulnerability and increase of energy efficiency, considering both economic losses and environmental impacts, is discussed through a parametric application to an exemplificative case-study building. Such framework accounts for the economic and environmental contributions of initial construction, operational energy consumption, earthquake-induced damage repair activities, retrofitting interventions, and demolition. One-off and annual monetary expenses and environmental impacts through the building life cycle are suggested as meaningful performance metrics to develop an integrated classification system for buildings and to identify the optimal renovation strategy leading to a combined reduction of economic and environmental impacts, depending on the climatic conditions and the seismic hazard at the site of interest. The illustrative application of the framework to an existing school building is then carried out, investigating alternative retrofitting solutions, including either sole structural retrofitting options or sole energy refurbishments, as well as integrated strategies that target both objectives, with a view to demonstrate its practicality and to explore its ensuing results. The influence of seismic hazard and climatic conditions is quantitatively investigated, by assuming the building to be located into different geographic locations.
Impacts of invasive annual grasses and their litter vary by native functional strategy
Authors: LaForgia Marina L. 
Published: April 2021

AbstractInvasive species may act as a functional filter on native communities by differentially affecting species with different trait values. Across environments, invasive plants typically display traits associated with high resource acquisition and fast growth. Conversely, native plants, especially those in water-limited environments, tend to adopt one of two functional strategies: fast growth during high resource availability to avoid stress (resource-acquisitive), or slow growth during resource-poor conditions to tolerate stress (resource-conservative). While invasive competition can be a strong filter on these groups, many invaders also alter the structure of native communities through their accumulation of litter. How fast-growing invaders with litter shift native functional communities remains unknown. To elucidate these functional shifts, I manipulated invasive annual grasses and their litter in an annual grassland and followed the demographic rates of six native annual forb species that varied in their functional strategy. Live grass competition alone decreased per capita growth rates of resource-acquisitive natives and had no effect on resource-conservative natives. The presence of litter, however, decreased growth rates in both functional types of natives, with stronger declines in resource-acquisitive species through differential effects on seed set and germination. Invaders in this system thus create an unfavorable environment for natives through litter, limiting the capacity of both resource-acquisitive and resource-conservative native forbs to maintain high population growth. These findings suggest that grass invasions have the potential to dramatically shift the functional composition of native communities through the time-lagged effects of their litter.
Parental occupation and childhood germ cell tumors: a case–control study in Denmark, 1968–2016
Authors: Hall Clinton , Hansen Johnni , Olsen Jørn , He Di , von Ehrenstein Ondine S. , Ritz Beate , Heck Julia E. 
Published: April 2021

Abstract
Purpose
To examine associations between parental occupation and childhood germ cell tumors (GCTs) in offspring while distinguishing by common histologic subtype (i.e., yolk sac tumor and teratoma).

Methods
This population-based case–control study included childhood GCT cases in Denmark diagnosed 1968–2015 (< 16 years old at diagnosis) and sex and birth year-matched controls. Demographic information and parental employment histories were obtained from Danish registries. Parental occupation was assessed by industry; job-exposure matrices were used to examine specific occupational exposures (i.e., potentially carcinogenic organic solvents and social contact). Conditional multivariable logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CIs).

Results
Overall, 178 childhood GCT cases (50 yolk sac tumors; 65 teratomas) and 4,355 controls were included for analysis. Maternal employment in education during pregnancy was associated with offspring GCTs (OR 2.45, 95% CI 1.23–4.90), especially yolk sac tumors (OR 5.27, 95% CI 1.94–14.28). High levels of both maternal and paternal occupational social contact were also associated with offspring yolk sac tumors across all exposure periods (ORs 2.30–4.63). No signals were observed for paternal occupational solvent exposure, while imprecise associations were estimated for maternal exposure (e.g., dichloromethane exposure during pregnancy, OR 1.51, 95% CI 0.77–2.95).

Conclusion
Our findings suggest that parental occupation is associated with offspring GCTs, with most consistent evidence supporting an association between maternal employment in education or other high social contact jobs and offspring yolk sac tumors.
Grouping-Induced Numerosity Biases Vary with Autistic-Like Personality Traits
Authors: Pomè Antonella , Caponi Camilla , Burr David Charles 
Published: April 2021

AbstractIndividuals with autism spectrum disorder are thought to have a more local than global perceptual style. We used a novel paradigm to investigate how grouping-induced response biases in numerosity judgments depend on autistic-like personality traits in neurotypical adults. Participants judged the numerosity of clouds of dot-pairs connected by thin lines, known to cause underestimation of numerosity. The underestimation bias correlated strongly with autism-spectrum quotient (r = 0.72, Bayes factor > 100), being weaker for participants with high autistic traits. As connecting dots probably activates global grouping mechanisms, causing dot-pairs to be processed as an integrated whole rather than as individual dots, the results suggest that these grouping mechanisms may be weaker in individuals self-reporting high levels of autistic-like traits.
Growing Old in a Transnational Setting: Investigating Perceptions of Ageing and Changing Filial Ties Among Older Indians in Saskatoon
Authors: Gangopadhyay Jagriti 
Published: April 2021

AbstractNumerous studies have examined the experience of growing old in a transnational context among Indians. However, in most of these studies, the older adults had immigrated as senior citizens to be with their adult children. Indians who have grown old in transnational settings have not been examined in detail in the gerontological scholarship. Adopting a cross-cultural lens, the present study focusses on perceptions of ageing among older Indians who have grown old in the city of Saskatoon. The study demonstrates how these older Indians refute the Successful Ageing model and accept their physical weaknesses in their course of ageing. Additionally, the study also examines how caregiving arrangements and intergenerational relationships are shaped among these older Indians and their adult children, in a transnational city, such as Saskatoon. Finally, the study highlights how later life gender roles are constructed in a transnational backdrop.
Fatty Acids and Oxylipins in Osteoarthritis and Rheumatoid Arthritis—a Complex Field with Significant Potential for Future Treatments
Authors: Mustonen Anne-Mari , Nieminen Petteri 
Published: April 2021

AbstractPurpose of ReviewOsteoarthritis (OA) and rheumatoid arthritis (RA) are characterized by abnormal lipid metabolism manifested as altered fatty acid (FA) profiles of synovial fluid and tissues and in the way dietary FA supplements can influence the symptoms of especially RA. In addition to classic eicosanoids, the potential roles of polyunsaturated FA (PUFA)-derived specialized pro-resolving lipid mediators (SPM) have become the focus of intensive research. Here, we summarize the current state of knowledge of the roles of FA and oxylipins in the degradation or protection of synovial joints.Recent FindingsThere exists discordance between the large body of literature from cell culture and animal experiments on the adverse and beneficial effects of individual FA and the lack of effective treatments for joint destruction in OA and RA patients. Saturated 16:0 and 18:0 induce mostly deleterious effects, while long-chain n-3 PUFA, especially 20:5n-3, have positive influence on joint health. The situation can be more complex for n-6 PUFA, such as 18:2n-6, 20:4n-6, and its derivative prostaglandin E2, with a combination of potentially adverse and beneficial effects. SPM analogs have future potential as analgesics for arthritic pain.SummaryAlterations in FA profiles and their potential implications in SPM production may affect joint lubrication, synovial inflammation, pannus formation, as well as cartilage and bone degradation and contribute to the pathogeneses of inflammatory joint diseases. Further research directions include high-quality randomized controlled trials on dietary FA supplements and investigations on the significance of lipid composition of microvesicle membrane and cargo in joint diseases.
Evaluation of a novel particle-based multi-analyte technology for the detection of anti-fibrillarin antibodies
Authors: Mahler Michael , Kim Grace , Roup Fabrece , Bentow Chelsea , Fabien Nicole , Goncalves David , Palterer Boaz , Fritzler Marvin J. , Villalta Danilo 
Published: April 2021

AbstractSystemic sclerosis (SSc) is a heterogeneous autoimmune disease associated with several anti-nuclear antibodies (ANA), including those in the classification criteria (anti-centromere, anti-topoisomerase I (Scl-70), anti-RNA Pol III). However, the presence of less common antibodies such as anti-fibrillarin (U3-RNP) that generate a clumpy nucleolar pattern by HEp-2 indirect immunofluorescence assay (IFA, ICAP AC-9) are considered disease specific and are with clinical subsets of SSc, therefore playing a role in diagnosis and prognosis. A specific and sensitive anti-fibrillarin assay would be an important addition to serological diagnosis and evaluation of SSc. The goal of this study was to evaluate a new particle-based multi-analyte technology (PMAT) for the measurement of anti-fibrillarin antibodies. A total of 149 patient samples were collected including 47 samples from France (Lyon and Paris, n = 32) and Italy (Careggi Hospital, Florence, n = 15) selected based on AC-9 HEp-2 IFA staining (> 1:640, clumpy nucleolar pattern) and 102 non-SSc controls (inflammatory bowel disease (IBD) n = 20, Sjögren’s syndrome (SjS) n = 20, infectious disease (ID) n = 7, systemic lupus erythematosus (SLE) n = 17, rheumatoid arthritis (RA) n = 17, and healthy individuals (HI) n = 21). All samples were tested on the anti-fibrillarin PMAT assay (research use only, Inova Diagnostics, USA). Additionally, the 47 anti-fibrillarin positive samples were also tested on PMAT assays for detecting other autoantibodies in ANA-associated rheumatic diseases (AARD). Anti-fibrillarin antibody data performed by fluorescence enzyme immunoassay (FEIA, Thermo Fisher, Germany) was available for 34 samples. The anti-fibrillarin PMAT assay was positive in 31/32 (96.9%, France) and 12/15 (80.0%, Italy) of samples preselected based on the AC-9 IIF pattern (difference p = 0.09). Collectively, the PMAT assay showed 91.5% (95% confidence interval (CI): 80.1–96.6%) sensitivity with 100.0% (95% CI: 96.4–100.0%) specificity in non-SSc controls. Strong agreement was found between PMAT and FEIA with 100.0% positive qualitative agreement (34/34) and quantitative agreement (Spearman’s rho = 0.89, 95% CI: 0.77.9–0.95%, p < 0.0001). Although most anti-fibrillarin positive samples were mono-specific (69.8%), some expressed additional antibodies (namely Scl-70, centromere, dsDNA, Ro52, Ro60, SS-B, Ribo-P, DFS70, and EJ). In conclusion, this first study on anti-fibrillarin antibodies measured using a novel PMAT assay shows promising results where the new PMAT assay had high level of agreement to FEIA for the detection of anti-fibrillarin antibodies. The availability of novel AFA assays such as PMAT might facilitate the clinical deployment, additional studies, standardization efforts, and potentially consideration of AFA for next generations of the classification criteria.
Influence of transgenesis on genome variability in cucumber lines with a thaumatin II gene
Authors: Skarzyńska Agnieszka , Pawełkowicz Magdalena , Pląder Wojciech 
Published: April 2021

AbstractThe development of new plant varieties by genetic modification aims at improving their features or introducing new qualities. However, concerns about the unintended effects of transgenes and negative environmental impact of genetically modified plants are an obstacle for the use of these plants in crops. To analyze the impact of transgenesis on plant genomes, we analyze three cucumber transgenic lines with an introduced thaumatin II gene. After genomes sequencing, we analyzed the transgene insertion site and performed variant prediction. As a result, we obtained similar number of variants for all analyzed lines (average of 4307 polymorphisms), with high abundance in one region of chromosome 4. According to SnpEff analysis, the presence of genomic variants generally does not influence the genome functionality, as less than 2% of polymorphisms have high impact. Moreover, analysis indicates that these changes were more likely induced by in vitro culture than by the transgenesis itself. The insertion site analysis shows that the region of transgene integration could cause changes in gene expression, by gene disruption or loss of promoter region continuity.