bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multimodality imaging of an interventricular septum hydatid cyst
Authors: Prasad Krishna , Kumar Rupesh , Halder Vikram , Raju Muni , Negi Sunder Lal , Naganur Sanjeev 
Published: March 2021

Abstract
Background
Cardiac hydatid over the interventricular septum is extremely rare. Echinococcus infests humans as an accidental host. Echocardiography usually clinches the diagnosis of cardiac hydatid. However, multimodality imaging including cardiac magnetic resonance (CMR) imaging, computed tomography (CT), and positron emission tomography (PET) helps in supporting the diagnosis and surgical planning.

Case presentation
We present a 29-year-old male who presented with dyspnea and was found to have cardiac hydatid on the interventricular septum on echocardiography. CT and CMR clinched the diagnosis. CT pulmonary angiography showed extensive pulmonary thromboembolization and cavitary consolidation in lungs. PET showed no active uptake in cardiac hydatid. Post-surgical enucleation of the cyst his hypotension worsened and succumbed.

Conclusion
Cardiac hydatid has poor prognosis. Multimodality imaging helps in confirming the diagnosis and surgical planning.
Predictors and outcome of customer satisfaction: moderating effect of social trust and corporate social responsibility
Authors: Javed Sara , Rashidin Md. Salamun , Jian Wang 
Published: March 2021

AbstractThe study is to present an integrative model of predictors and outcome of customer satisfaction in the fast food sector of Pakistan and also examine its effects. Moreover, we also examined the contingent effect of social trust and corporate social responsibility (CSR) on the relationship between customer satisfaction and brand loyalty. Offline and online survey was conducted with four hundred fast food customers; valid data were assessed and analyzed through structural equation modeling and moderation step-by-step approach. Results demonstrate that restaurant stimuli such as food quality, service quality, atmosphere, price, restaurant location and a variety of food have strong significant effects on customer satisfaction, and customer satisfaction engendered brand loyalty. Social trust has a positive significant impact on the relationship between customer satisfaction and brand loyalty, whereas on the other side CSR has insignificant impact on the association. The study has practical implications for both restaurateurs and government. Restaurateurs should ensure the safety standards of foods, and the government can take an initiative to set proper policy and maintain the food safety standards by regulation.
The safety and efficacy of the trans-umbilical approach for pyloroplasty in the management of post-acid corrosive gastric outlet obstruction in children
Authors: Elhalaby Essam A. , Halawa Nezar Abd Erouf Abo , Elhalaby Ismael E. , Shawky Dina , Hassan Hussam , Almetaher Hisham A. 
Published: March 2021

Abstract
Background
Gastric outlet obstruction (GOO) may follow acid corrosive ingestion. Several surgical techniques have been reported after the failure of endoscopic dilatation. The aim of this study was to evaluate the feasibility and safety of Heinecke-Mikulicz pyloroplasty (HMP) through a circum-umbilical skin incision in children with pyloric stricture after accidental acid corrosive ingestion.

Results
Seven patients were males and 4 were females, their ages ranged from 17 months to 6 years at the time of definitive treatment. The surgery was completed successfully in all patients through the circum-umbilical incision. Vertical extension of skin incision was needed in one patient. The pylorus was grossly affected in 9 patients. Both pylorus and gastric antrum were involved in 2 patients. Nine patients had an excellent postoperative course with the cessation of vomiting and progressive weight gain. One patient developed postoperative recurrent stricture treated by gastrojejunostomy. Another patient with associated esophageal stricture responded to repeated endoscopic dilatation for the esophageal stricture and pyloroplasty for the pyloric stricture. No surgical site infection or wound dehiscence occurred in any patient.

Conclusion
Heinecke-Mikulicz pyloroplasty through a circum-umbilical approach is both feasible and safe in the majority of children with post-acid corrosive GOO. It is associated with satisfactory wound healing and excellent cosmetic outcome. Different techniques are recommended in cases of severe pyloric stricture associated with significant proximal gastric antral scarring.
Ligand Binding Prolongs Androgen Receptor Protein Half-Life by Reducing its Degradation
Authors: Astapova Olga , Seger Christina , Hammes Stephen R 
Published: March 2021

Abstract
Androgens are important in female reproduction, but the molecular actions of androgens in female reproductive tissues are not fully understood. We investigated the androgen-responsive transcriptome in human and mouse granulosa cells (GCs) and surprisingly found that the gene-regulation activity of androgen receptor (AR) in these cells is negligible. We then investigated extranuclear actions of AR and found that in human and mouse GCs, as well as in prostate cancer cells, dihydrotestosterone (DHT) dramatically increases the half-life of its own receptor protein. Using the human granulosa-like KGN cells, we show that this effect is not the result of increased AR gene transcription or protein synthesis, nor is it fully abrogated by proteasome inhibition. Knockdown of PTEN, which contributes to degradation of cytoplasmic AR, did not diminish AR accumulation in the presence of DHT. Using immunofluorescence cellular localization studies, we show that nuclear AR is selectively protected from degradation in the presence of DHT. Knockdown of importin 7 expression, a potential regulator of AR nuclear import, does not affect DHT-mediated nuclear accumulation of AR, suggesting importin 7-independent nuclear import of AR in GCs. Further, DNA binding is not required for this protective mechanism. In summary, we show that ligand binding sequesters AR in the nucleus through enhanced nuclear localization independent of DNA binding, thereby protecting it from proteasome degradation in the cytoplasm. This phenomenon distinguishes AR from other sex steroid receptors and may have physiological significance through a positive feedback loop in which androgen induces its own activity in male and female reproductive tissues.
Chance-Constrained Multiple Bin Packing Problem with an Application to Operating Room Planning
Authors: Wang Shanshan , Li Jinlin , Mehrotra Sanjay 
Published: March 2021

We study the chance-constrained bin packing problem, with an application to hospital operating room planning. The bin packing problem allocates items of random sizes that follow a discrete distribution to a set of bins with limited capacity, while minimizing the total cost. The bin capacity constraints are satisfied with a given probability. We investigate a big-M and a 0-1 bilinear formulation of this problem. We analyze the bilinear structure of the formulation and use the lifting techniques to identify cover, clique, and projection inequalities to strengthen the formulation. We show that in certain cases these inequalities are facet-defining for a bilinear knapsack constraint that arises in the reformulation. An extensive computational study is conducted for the operating room planning problem that minimizes the number of open operating rooms. The computational tests are performed using problems generated based on real data from a hospital. A lower-bound improvement heuristic is combined with the cuts proposed in this paper in a branch-and-cut framework. The computations illustrate that the techniques developed in this paper can significantly improve the performance of the branch-and-cut method. Problems with up to 1,000 scenarios are solved to optimality in less than an hour. A safe approximation based on conditional value at risk (CVaR) is also solved. The computations show that the CVaR approximation typically leaves a gap of one operating room (e.g., six instead of five) to satisfy the chance constraint. Summary of Contribution: This paper investigates a branch-and-cut algorithm for a chance-constrained bin packing problem with multiple bins. The chance-constrained bin packing provides a modeling framework for applied operations research problems, such as health care, scheduling, and so on. This paper studies alternative computational approaches to solve this problem. Moreover, this paper uses real data from a hospital operating room planning setting as an application to test the algorithmic ideas. This work, therefore, is at the intersection of computing and operations research. Several interesting ideas are developed and studied. These include a strengthened big-M reformulation, analysis of a bilinear reformulation, and identifying certain facet-defining inequalities for this formulation. This paper also gives a lower-bound generation heuristic for a model that minimizes the number of bins. Computational experiments for an operating room planning model that uses data from a hospital demonstrate the computational improvement and importance of the proposed approaches. The techniques proposed in this paper and computational experiments further enhance the interface of computing and operations research.
As razões da permanência escolar no Proeja: narrativas dos trabalhadores-estudantes do sertão de Alagoas
Authors: Silva Jailson Costa da , Freitas Marinaide Lima de Queiroz , Silva Suzi Cristiane Soares da 
Published: March 2021

O artigo tem por objetivo apresentar as razões da permanência escolar dos sertanejos-trabalhadores-estudantes que, motivados pelo sonho e pela determinação, permaneceram no Curso técnico de nível médio integrado em alimentos, no âmbito do Proeja, doInstituto Federal de Alagoas (Ifal) – campus Piranhas. Utilizamos o método de história de vida como ponte entre o individual e o social com base em Cipriani (1988) e Paulilo (1999). As narrativas foram construídas por meio da técnica da entrevista de História de vida (Queiroz, 1988). As vozes dos narradores, utilizadas como fontes, demonstraram que os motivos da permanência são oriundos da cooperação e solidariedade entre os colegas, apoio familiar, incentivo de alguns professores, e pela existência material de: transporte, materiais didáticos e auxílio financeiro. Nesse sentido, envolveu as permanências simbólica e material. .
A aplicação dos royalties na educação dos municípios da Região Metropolitana do Estado do Rio de Janeiro
Authors: Souza Fábio Araujo de , Menezes Janaina Specht da Silva 
Published: March 2021

Este artigo objetiva analisar a aplicação em educação dos recursos das compensações financeiras advindas da exploração de recursos naturais, sobretudo as do petróleo, xisto betuminoso e gás natural, realizada pelos municípios da Região Metropolitana do Estado do Rio de Janeiro (RMRJ). A partir das pesquisas bibliográfica e documental, é apresentada uma análise dos dados disponíveis nos sites dos Tribunais de Contas do Estado e do Município, bem como no da Transparência e/ou das Secretarias de Fazenda Municipais. Entre outros resultados, o trabalho revela que dos 22 municípios integrantes da RMRJ, apenas oito (36,4%) declararam investir parte desses recursos em educação, e, destes, apenas cinco disponibilizaram a descrição das despesas pagas, fato que dificulta a investigação e análise do destino desses recursos. Revela, ainda, que a destinação à educação, disposta no ordenamento jurídico, de 75% dos recursos dos royalties, vem sendo refreada por processos de judicialização, os quais aguardam julgamento no Supremo Tribunal Federal.
Potencialidades da História Oral na pesquisa e na form(ação) docente: percurso metodológico
Authors: Borges Vilmar José , Borges Jullizze Maia 
Published: March 2021

O presente artigo tem por objeto de estudo os pressupostos metodológicos de pesquisa da História Oral, e, por objetivo, desvelar e socializar as potencialidades dessa abordagem como alternativa para investigar as especificidades da relação entre os diferentes saberes/fazeres que envolvem a formação e a atuação docente. Para tanto, apoiados na abordagem da pesquisa bibliográfica, destaca a necessidade de investigações que voltem seus olhares para a internalidade do processo educativo, desvelando saberes e fazeres dos sujeitos em seus dinâmicos processos formativos. Nessa direção, enfatiza as potencialidades da História Oral. Conclui-se que essa abordagem se mostra ainda mais potente ao permitir ao pesquisador adotar, em suas pesquisas, um híbrido constituído por dois ou mais procedimentos, que podem se relacionar sem causar danos teórico-metodológicos a cada um separadamente.
Os atravessamentos da saúde na educação e os efeitos da governamentalidade
Authors: Porto Roberta Mendonça , Amado Luiz Antonio Saléh 
Published: March 2021

Este artigo objetiva discutir os efeitos da implementação da Política Nacional de Educação Especial de 2008 no município de Linhares, ES, a partir do encontro entre educação e saúde. Os dados dessa pesquisa referem-se ao ano de 2010 e foram analisados sob as lentes da Análise Institucional. Com base nesses pressupostos, nos voltamos para a nova organização da rede, após a implementação da PNEE 2008, que estabeleceu uma parceria entre saúde e educação. A partir disso, observou-se o aumento da demanda de avaliação das dificuldades de aprendizagem e de problemas comportamentais dos estudantes por parte das escolas e de seus profissionais. Este efeito emergiu neste trabalho como um analisador histórico: Aumento da demanda por avaliação, apontando para como tem se constituído a relação entre saúde e educação no âmbito da escola e abrindo espaços para novas organizações desta relação. Questões até então corriqueiras no cotidiano escolar passaram a ser consideradas disfunções neuropsicológicas dos estudantes, demandando, assim, a avaliação de uma equipe de saúde. Diante disso, a equipe de trabalho elaborou uma série de estratégias que pudessem minimizar o processo de medicalização escolar que estava se instituindo naquela rede. Essas estratégias aproximaram os profissionais da saúde e da educação, permitindo que os profissionais da escola colocassem suas práticas em análise e produzissem mudanças nas relações e práticas da escola.
Pregnancy intention and gestational age at first antenatal care visit in Lesotho
Authors: Mkandawire Paul , Kangmennaang Joseph , Walker Chad , Antabe Roger , Atuoye Kilian , Luginaah Isaac 
Published: March 2021

Background/aims With coverage of antenatal care in sub-Saharan Africa approaching a universal level, attention is now turning to maximising the life-saving potential of antenatal care. This study assessed the gestational age at which pregnant mothers make their first antenatal visit in the context of high antenatal coverage in Lesotho. Methods For the purposes of this study, secondary data from the Demographic and Health Survey of 2014 was analysed. These data were collected in 2014, via an interviewer administered questionnaire. Survival analysis was applied to the data, using Stata SE 15 to compute time ratios that estimate time to first antenatal visit in Lesotho. Results Despite near universal coverage, only 24% of mothers start antenatal care before 12 weeks of gestation, as recommended by the World Health Organization. In addition, mothers with unwanted pregnancies are most likely to delay antenatal care until later in gestation, followed by mothers with mistimed pregnancies. Education, but not wealth, correlates with the start of antenatal care. Conclusions Having achieved near universal coverage, emphasising a prompt start and adherence to recommended visits could optimise the life-saving potential of antenatal care in Lesotho.
The heart: an amazing organ
Authors: Peate Ian 
Published: March 2021

This article provides an overview of the anatomy and physiology of the heart. The heart is an amazing organ that continuously pumps oxygenated blood throughout the body to sustain the life of the various organs. The heart pumps out around 7500 litres of blood per day. The heart functions without us having to think about it, beating around 70 times per minute, this equates to just over 100 000 heart beats each day. This article discusses the structure of the heart, along with its various functions. The conduction system is outlined, as well as the blood flow through the heart. A glossary of terms is provided and a short test to check your knowledge.
Platelet-derived extracellular vesicles promote osteoinduction of mesenchymal stromal cells
Authors: Antich-Rosselló Miquel , Forteza-Genestra Maria Antònia , Calvo Javier , Gayà Antoni , Monjo Marta , Ramis Joana M. 
Published: March 2021

AimsPlatelet concentrates, like platelet-rich plasma (PRP) and platelet lysate (PL), are widely used in regenerative medicine, especially in bone regeneration. However, the lack of standard procedures and controls leads to high variability in the obtained results, limiting their regular clinical use. Here, we propose the use of platelet-derived extracellular vesicles (EVs) as an off-the-shelf alternative for PRP and PL for bone regeneration. In this article, we evaluate the effect of PL-derived EVs on the biocompatibility and differentiation of mesenchymal stromal cells (MSCs).MethodsEVs were obtained first by ultracentrifugation (UC) and then by size exclusion chromatography (SEC) from non-activated PL. EVs were characterized by transmission electron microscopy, nanoparticle tracking analysis, and the expression of CD9 and CD63 markers by western blot. The effect of the obtained EVs on osteoinduction was evaluated in vitro on human umbilical cord MSCs by messenger RNA (mRNA) expression analysis of bone markers, alkaline phosphatase activity (ALP), and calcium (Ca2+) content.ResultsOsteogenic differentiation of MSCs was confirmed when treated with UC-isolated EVs. In order to disprove that the effect was due to co-isolated proteins, EVs were isolated by SEC. Purer EVs were obtained and proved to maintain the differentiation effect on MSCs and showed a dose-dependent response.ConclusionPL-derived EVs present an osteogenic capability comparable to PL treatments, emerging as an alternative able to overcome PL and PRP limitations. Cite this article: Bone Joint Res 2020;9(10):667–674.
FPGA-based implementation of two-step schedulers for modular optical interconnection networks
Authors: Borromeo Justine Cris , Cerutti Isabella , Castoldi Piero , Reyes Rosula , Andriolli Nicola 
Published: March 2021

Optical interconnection networks promise to overcome the limitations of current electronic switching fabrics, enabling higher throughput, lower latency, and lower power consumption. Multi-plane architectures, based on multiple optical switching domains (e.g., space, time, wavelength, orbital angular momentum), are gaining research attention because of their modularity and scalability compared to single-domain switches. An effective scheduler, namely, the two-step scheduler (TSS), has been proposed for multi-plane optical interconnection networks, exploiting their modularity to speed up computations while satisfying the peculiar scheduling constraints. In this paper, a hardware implementation of TSS for modular optical interconnection networks is presented and thoroughly assessed. Both scheduling steps are parallelized with the aim of optimizing the execution time. iSLIP and longest queue first (LQF) scheduling algorithms are exploited in each step, resulting in four TSS configurations that are compared among each other and with classical single-step schedulers (SSSs) in terms of scheduling and hardware performance. TSS outperforms SSS in terms of the number of iterations, maximum operating frequency, worst-case scheduling duration, and required logic resources (i.e., scalability) at the expense of a slight latency penalty. Among all TSS configurations, LQF-based TSS guarantees the lowest scheduling latency, while iSLIP-based TSS minimizes the scheduling duration and the use of field programmable gate array (FPGA) resources.
Sensitivity enhancement of a difference interferometer refractive index sensor based on a silicon-on-insulator hybrid plasmonic waveguide
Authors: Okda Hesham A. , Rabia Sherif I. , Shalaby Hossam M. H. 
Published: March 2021

A refractive index (RI) sensor using a silicon-on-insulator hybrid plasmonic waveguide (HPWG) difference interferometer is proposed. We first provide a rigorous analysis that enables the construction of the modal characteristic equations of the TM- and TE-polarized modes in a HPWG. These equations are solved to get the modes’ complex effective indices in addition to their electromagnetic power distributions. The feature of polarization spatial diversity in HPWGs is then exploited to design a difference interferometer with a superior sensing capability. Our results reveal that the proposed device has a lower limit of detection of

1.32
×

10

−
6

refractive index unit (RIU) and a sensitivity of

756.2
π

r
a
d

/

R
I
U

at a wavelength of 1550 nm, accounting for a greater than 50% improvement to the sensitivities of recently published all-dielectric interferometers. Moreover, the sensing interactive length in this work is shown to be 1396 µm, acquiring more than a threefold reduction compared to those reported in the literature. In addition, the propagation loss is reduced by more than

5
×

10
2

times compared to its value in the case of a surface plasmon interferometer, which is found to enhance the detectable power level by 13.6 dB. Furthermore, the proposed HPWG difference interferometer is investigated with a broadband interrogation. Our findings come out with a high density of local extrema of the light interference intensity, for a short sensing interactive length, in the spectral range of interest (from 1490 to 1610 nm), which is favorable for accurate statistical analysis of the interference intensity signal.