bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sarcopenia Measured by Temporalis Muscle Thickness Independently Predicts Early Relapse and Short Survival in Primary CNS Lymphoma
Authors: Bonm Alipi , Menghini Anthony , Graber Jerome J. 
Published: November 2021

Abstract
Introduction: Primary CNS lymphoma (PCNSL) outcomes diverge between a majority of patients who achieve long term remission and a smaller minority who have aggressive disease course and die in the first year. Sarcopenia is increasingly recognized as a powerful predictor of mortality in brain and systemic cancers. Temporalis muscle thickness (TMT) is a validated radiographic measure of sarcopenia. We hypothesized that patients with TMT less than one standard deviation below the mean (“very thin TMT”) would go on to have shorter survival. Methods: Two blinded operators retrospectively measured TMT in 99 consecutive pretreatment brain MRIs from patients that were subsequently diagnosed with PCNSL. Results: On univariate analysis TMT predicted early progression (HR 4.25, 95% CI 1.95 – 9.29, p<0.001) and early mortality (HR 4.38, 95% CI 2.25 – 8.53, p<0.001), and these effects were maintained in subgroups of patients both <65 and ³65 years of age. Very thin TMT predicted mortality more robustly than IELSG or MSKCC scores. Patients with very thin TMT received fewer cycles of high-dose methotrexate (HD-MTX) and were less likely to receive consolidation. On multivariate analysis which included the covariates age, sex, TMT, ECOG, BMI, lifetime doses of HD-MTX, and consolidation, very thin TMT was independently associated with both early progression (HR = 7.87, 95% CI = 3.55 – 17.45, p<0.001) and short survival (HR 4.49, 95% CI = 1.94 – 10.40, p<0.001). Conclusions: We conclude that PCNSL patients with very thin TMT are at high risk for relapse and early mortality. Future trials should stratify patients by TMT to avoid potential confounding.
The Effects of Ram Exposure, Progestogen and eCG on Reproductive Performance of Fat Tail Ewes in Non-Breeding Season
Authors: Garoussi Massoud - Talebkhan , Mavadati Omid , Bahonar Mohammad Ali , Dabiri Mehran 
Published: November 2021

Abstract
Sheep are considered short-day breeders. Exposure of rams to anestrus ewes results in an increase in LH secretion. The aims of this study was to determine whether the presence and exposure of rams can effect on reproductive performance such as: pregnancy rate, litter size, sex of lamb, fecundity rate and prolificacy rate of fat tail Iranian Shaal breed ewes in non-breeding season using progesterone (p4) analogue with or without equine chorionic gonadotropin (eCG). Totally, 100 ewes out of 138 non-cyclic ewes with <0.5ng/ml P4 were selected for this study. They were aged 2 to >7 years old. They were stratified to two groups (control and treatment). The ewes in treatment and control groups received 13 days a sponge containing 60 mg medroxyprogesterone acetate (MPA). The treatment group consists of 3 subgroups and each group contains 25 ewes equally. They were included: 1- P4, eCG and Ram exposure. 2- P4 and ram exposure. 3- P4 and eCG. Ewes in control group received only P4. The ewes were located in isolated corrals for 40 days. The ram to ewe ratio was 1 to 5. Twenty healthy rams were housed in an isolated pen from ewes with distance 1500 m during 40 days. Rams exposed three days before sponge withdraw (day 10). They were separated by considerable distance (2 meters) using fence. The related groups received 500 IU eCG on the day of sponge removal (day 13). The rams were released into the ewe flock after removing the sponge in treatment and control groups. Pregnancy diagnosis performed using transabdominal ultrasonography. The obtained data analyzed using SPSS version 16. The conception rate in treatment and control groups were differed significantly (P<0.01). The conception rate in P4+ram exposure+ eCG, P4+ramexposure and P4+ eCG were 96%(no.24), 80%(no.20) and 88%(no.22), respectively. However, the conception rate in control group was 60% (no. 15). The fecundity rates were 136%, 100% and 124% in treatment subgroups, however, it was 84% in control group, respectively. There were no significant differences among genus and weight of lambs in treatments subgroups and control group (P>0.05). It is concluded that ram exposure can increase significantly reproductive performance in non-breeding season fat tailed ewes Shaal breed.
Nestin+ Mesenchymal Precursors Generate Distinct Spleen Stromal Cell Subsets and Have Immunomodulatory Function
Authors: Huang Jing , Li Minrong , Deng Ronghai , Li Weiqiang , Jiang Meihua , Xiang Andy Peng , Zhang Xiaoran 
Published: November 2021

Abstract
Background
Mesenchymal stromal cells (MSCs) are known to be widespread in many tissues and possess a broad spectrum of immunoregulatory properties. They have been used in the treatment of a variety of inflammatory diseases; however, the therapeutic effects are still inconsistent owing to their heterogeneity. Spleen stromal cells have evolved to regulate the immune response at many levels as they are bathed in a complex inflammatory milieu during infection. Therefore, it is unknown whether they have stronger immunomodulatory effects than their counterparts derived from other tissues.
Methods
Here, using a transgenic mouse model expressing GFP driven by the Nestin (Nes) promoter, Nes-GFP+ cells from bone marrow and spleen were collected. Artificial lymphoid reconstruction in vivo was performed. Cell phenotype, inhibition of T cell inflammatory cytokines, and in vivo therapeutic effects were assessed.
Results
We observed Nes-GFP+ cells colocalized with splenic stromal cells and further demonstrated that these Nes-GFP+ cells had the ability to establish ectopic lymphoid-like structures in vivo. Moreover, we showed that the Nes-GFP+ cells possessed the characteristics of MSCs. Spleen-derived Nes-GFP+ cells exhibited greater immunomodulatory ability in vitro, and more remarkable therapeutic efficacy in inflammatory diseases, especially inflammatory bowel disease (IBD) than bone marrow-derived Nes-GFP+ cells.
Conclusions
Overall, our data showed that Nes-GFP+ cells contributed to subsets of spleen stromal populations and possessed the biological characteristics of MSCs with a stronger immunoregulatory function and therapeutic potential than bone marrow-derived Nes-GFP+ cells.
Screening and Evaluating Novel Autoantibodies Based on Proteomic Chips in Diagnosis of Esophageal Squamous Cell Carcinoma
Authors: Han Zhuo , Wu Jinyu , Sun Guiying , Cui Chi , Qiu Cuipeng , Ye Hua , Dai Liping , Wang Keyan , Shi Jianxiang , Wang Peng 
Published: November 2021

Abstract
Background

More and more studies have confirmed that TAAbs could be used as potential biomarkers for tumor patients. The aim of this study is to identify novel TAAbs through proteomic chips and construct a diagnostic model to discriminate esophageal squamous cell carcinoma (ESCC) cases from benign esophageal diseases cases and normal controls (NCs).
Methods

The human proteomic chips were used to screen TAAbs. Enzyme-linked immunosorbent assay (ELISA) was adopted to verify and validate the candidate TAAbs which were screened by the chips in verification phase (90 ESCC cases and 90 NCs) and validation phase (126 ESCC cases, 237 benign esophageal diseases cases and 126 NCs). Based on the candidate TAAbs, then the diagnostic model for ESCC was constructed by logistic regression analysis in the training group and validated in the testing group.
Results

Firstly, thirteen potential candidate TAAbs were identified by proteomic chips. In verification phase, the titers of six TAAbs (anti-MAGEA1, anti-VCL, anti-PRKCZ, anti-TP53, anti-NFKB1 and anti- MAGEA4) in ESCC cases were higher than those in NCs while other seven TAAbs showed no difference. Subsequently, six candidate TAAbs were validated further in validation phase. Finally, the logistic regression model with 3 TAAbs (anti-MAGEA1, anti-VCL, anti-TP53) could discriminate ESCC cases from NCs with area under curve(AUC)of 0.80 in the training group and 0.73 in the testing group, respectively. Meanwhile, the model could discriminate ESCC cases from benign esophageal diseases cases with AUC of 0.74.
Conclusion

The study has identified six novel TAAbs through protein chips and constructed a diagnostic model. The panel showed great performance to distinguish ESCC cases from benign esophageal diseases cases and NCs.
Predicting Value of Perirenal Fat Thickness for Metabolic Syndrome in Patients with Newly-Diagnosed Type 2 Diabetes
Authors: Guo Xiu Li , Tu Mei , Chen Yang , Wang Wei 
Published: November 2021

Abstract
Objective

Increasing evidences suggested that perirenal fat thickness (PrFT) was associated with metabolic risk factors, this study aimed to assess the association between PrFT with components of metabolic syndrome (MetS) and explore the value of PrFT in predicting MetS among Newly-Diagnosed type 2 diabetes(T2DM).
Method

A total of 445 patients with Newly-Diagnosed T2DM from southern China were enrolled into this study. Demographic and anthropometric information were collected. PrFT was evaluated by CT scanning on Revolution VCT 64. Binomial logistic regression analysis and receiver operating characteristics (ROC) curves were conducted to assess the value and optimal cutoff of PrFT for predicting MetS divided by sex.
Results

The prevalence of MetS was 58.2% in Newly-Diagnosed T2DM.Correlation analysis showed that PrFT was significantly correlated with metabolic risk factors (BMI, WC, TG, HDL-c, SBP, DBP, UA and HOMA-IR). PrFT was also shown to be independently associated with MetS after adjustment for other confounders, the ORs(95%CI) were 1.33(1.01~1.74) in men and 1.53(1.08~2.17) in women(P<0.05). ROC curves showed a good predictive value of PrFT for MetS, the the areas under the curve of ROC values of PrFT predicting MetS were 0.895(95% CI 0.852~0.939) in men and 0.910(95% CI 0.876~0.953) in women(P<0.001). The optimal cut-off values of PrFT were 14.6 mm (sensitivity: 83.8%, specificity: 89.6%) for men and 13.1 mm (sensitivity: 87.6%, specificity: 91.1%) for women.
Conclusions

PrFT was significantly independent with MetS and showed a powerful predictive value for MetS, which suggested PrFT could be a potential indicator to help clinicians to screen high-risk groups in Newly-Diagnosed T2DM.
Clinical Trial Registration:

This study was registered in Clinical Trials. Gov (ChiCTR2100052032).
Association of Diabetes Complications With Depression and Suicidality in Hospitalized Patients: a Multicenter Cross-sectional Study
Authors: Pakdin Majid , Ebrahimi Alireza , Jahromi Mohammadsaeed Gharaati , Firoozabadi Ali 
Published: November 2021

Abstract
Background: Diabetes mellitus and depression are both considered the most prevalent diseases of the recent century. On the other hand, it is estimated that the rate of depression is nearly doubled in diabetic patients compared with the general population.Method: A total of 89 patients, who were admitted to the hospital because of the complications of the disease, were voluntarily and conveniently participated in the study. The participants were given the questionnaires of Beck Depression Inventory-2nd-edition and Beck Scale for Suicide Ideation. They were divided into two age groups: 18-50 years old and 50-75 years old. Control group, consisting of 89 individuals without any underlying disease, were randomly selected from the patients’ visitors, matched with the participants according to the age group and gender. Statistical analysis was performed between the two groups based on scores obtained. Results: Beck Depression Inventory Scale score was significantly higher, regardless of age, in the patient group compared to the control group. However, there was no significant difference between the scores of Beck Scale for Suicide Ideation between the patient group and the control group. In the patient group, it was found that among the variables, female gender, and diabetic foot were associated with higher severity of depression symptoms. Conclusion: It is vitally essential for diabetic patients to undergo periodic psychiatric evaluation. Early diagnosis of depression could help them to better cope with their mental health issue, and as a result, it will decrease risk of suicidal ideation and other consequences.
Photon-Pair Generation from Chip-Scale Cs Atomic Vapor Cell
Authors: Kim Heewoo , Park Jiho , Hong Hyun-Gue , Kwon Taeg Yong , Park Jongchenol , Moon Han Seb 
Published: November 2021

Abstract
The realization of a narrowband photonic quantum source based on a chip-scale atomic device is considered essential in the practical development of photonic quantum information science and technology. In this study, we present the first step toward the development of a photon-pair source based on a microfabricated chip-scale Cs atomic vapor cell. Time-correlated photon pairs from the millimeter-scale Cs vapor cell are emitted via the spontaneous four-wave mixing process of the cascade-type 6S1/2–6P3/2–8S1/2 transition of 133Cs. The maximum normalized cross-correlation value between the signal and idler photons is measured as 622(8) under a weak pump power of 10 mW. Our photon source violates the Cauchy–Schwartz inequality by a factor of >105. We believe that our approach has very important applications in the context of realizing practical scalable quantum networks based on atom–photon interactions.
Joint Effects of Co-Exposure to Polycyclic Aromatic Hydrocarbons Exposure and Smoking with XPC Polymorphisms on Damage in Exon 2 of KRAS Gene Among Young Coke-Oven Workers
Authors: Chen Siqin , He Yuefeng , Yin Xingyue , He Qinghua , Li Xiaomei , Yan Maosheng , Huang Suli , Yang Binyao 
Published: November 2021

Abstract
Background

Genetic polymorphisms may contribute to variable individual susceptibility to DNA damage induced by co-exposure to polycyclic aromatic hydrocarbons (PAHs) and smoking. Here, we evaluate the joint effects of co-exposure to PAHs and smoking with polymorphisms in XPC, alone or combined, on damage in exons.
Methods

288 healthy male coke-oven workers were enrolled into this study, urinary 1-hydroxypyrene (1-OH-pyr), as an indirect and sensitive indicator of PAHs exposure, was detected. Base modification in exons of KRAS and BRAF gene, and polymorphisms of XPC were determined by real-time PCR in plasma samples.
Results

We observed urinary 1-OH-pyr was positively related to damage index of exon 2 of KRAS gene (KRAS-2) and damage index of exon 15 of BRAF gene (BRAF-15) (both p < 0.001), and KRAS-2 and BRAF-15 were both significantly associated with increased urinary 1-OH-pyr (both p trend < 0.001). A stratified analysis found that urinary 1-OH-pyr was found to be significantly associated with KRAS-2 in both smokers (p < 0.001) and nonsmokers (p < 0.05), while urinary 1-OH-pyr was significantly associated with BRAF-15 only in smokers (p < 0.001). Additionally, rs2228001 in the XPC gene was positively associated with KRAS-2 (p trend < 0.001), and the high levels of 1-OH-pyr were linearly associated with KRAS-2 only in rs2228001 GG+GT genotype carriers (p < 0.001); However, another SNP rs3731055 in the XPC gene was associated with lower KRAS-2 (p trend = 0.006), and the high levels of 1-OH-pyr were linearly associated with KRAS-2 only in rs3731055 GG genotype carriers (p < 0.001). Moreover, KRAS-2 significantly increased with high levels of 1-OH-pyr exposure, smoking, rs2228001 G-allele, and rs3731055 GG homozygote genotype, and we found the most severe KRAS-2 among subjects carrying all 4 of the above risk factors.
Conclusions

Our findings indicated that the co-exposure effect of PAHs and cigarette smoking could increase the risk of damage in exon 2 of KRAS by a mechanism partly involving XPC polymorphisms.
The Expression of YKL-40 in Peripheral Blood of Colorectal Cancer and Its Effect on the Proliferation and Angiogenesis of Colorectal Cancer Cells
Authors: Yang Shaohui , Shen Jie , Zhao Yibin 
Published: November 2021

Abstract
Objective To observe the expression of YKL-40 in the serum of patients with colorectal cancer, and to study the effect of YKL-40 gene on the proliferation and angiogenesis of colon cancer cell lines. Methods The serum of patients with colorectal cancer, precancerous lesions, and healthy controls were collected, and the expression of YKL-40 was detected by enzyme-linked immunosorbent assay (ELISA) technology. Screened cell lines with high expression of YKL-40 from colon cancer cell lines HCT-15, HCT-116, SW480, interfered with YKL-40 gene expression through siRNA technology, and co-cultured with bevacizumab, and detected cells with CCK8 method Proliferation, cell formation test to detect blood vessel formation. Results The mean values of serum YKL-40 in the colorectal cancer group, precancerous lesion group and control group were (178.50±71.91) μg/L, (91.37±35.79) μg/L and (78.23±26.52) μg/L, respectively. The colorectal cancer group (preoperative) was significantly higher than the precancerous lesion group and the control group (P <0.01). The precancerous lesion group was higher than the control group, but the difference between the two was not statistically significant (P = 0.244). The expression of YKL-40 was positively correlated with the stage of colorectal cancer (P <0.05). There was no significant difference in the expression of serum YKL-40 before and after surgery (p=0.07). HCT-116 is a YKL-40 highly expressing cell line. After inhibiting the expression of this gene, the survival rate of the experimental group was 78.75%, which was significantly lower than that of the control group (p<0.05). The angiogenesis test is used to detect the angiogenesis ability. siRNA interference with YKL-40 gene and the addition of bevacizumab can inhibit the angiogenesis ability in vitro. Moreover,the vascular inhibitory effect of bevacizumab in the experimental group was stronger than that in the control group. Conclusion YKL-40 is highly expressed in the peripheral blood of patients with colorectal cancer and is related to the tumor stage. The HCT-116 colon cancer cell line has a high expression of YKL-40. Interfering with the expression of YKL-40 can inhibit cell proliferation and angiogenesis. It suggests that YKL-40 plays an important role in the occurrence and development of colorectal cancer.
The Cross Talk Between ROS And NO In The Viability Decline of Cryopreserved Pollen From Paeonia Lactiflora
Authors: Ren Ruifen , Zhang Lingling , Zhou Hao , Jiang Xueru , Liu Yan 
Published: November 2021

Abstract
Reactive oxygen species (ROS) and nitric oxide (NO), two common active molecules, are both involved in changes in viability after liquid nitrogen (LN) storage, but the relationship between these two molecules has not been examined in plant cryopreservation until now. In this study, the pollen of Paeonia lactiflora 'Fen Yu Nu' with significantly decreased viability after cryopreservation was used as the material. We studied the effects of the two regulators on each other and their biosynthesis and scavenging indices to explore the interaction between ROS and NO in pollen cryopreservation and its mechanism. The results showed that the contents of ROS and NO increased significantly with the decrease of pollen viability after cryopreservation, and changes in the ROS and NO content had a significant effect on post-LN pollen viability. The ROS content positively regulated the endogenous NO content and had significant effects on the expression level of NOS-like enzyme regulation gene CSU2 and its activity. Down-regulated NO had a positive effect on the ROS content, and it significantly affected the expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and its regulatory gene RBOHJ. It also significantly affected catalase (CAT) and substrates related to the ascorbic acid (AsA)-glutathione (GSH) antioxidant cycle system. These results indicate that there was a positive interaction between ROS and NO in pollen cryopreservation. The NOS biosynthesis pathway is one of the ROS-regulated NO pathways, and the NADPH oxidase, CAT and AsA-GSH antioxidant cycle systems are the key sites of regulation of the ROS content by NO.
Extrauterine Growth Restriction in Preterm Infants: How to Achieve Optimal Catch-Up Growth During Hospitalization?
Authors: Lan Si-Yuan , Zhang Rui , Zhong Gui-Mei , Pan Li-Ya , Fu Huan-Huan , Bei Fei , Hong Li 
Published: November 2021

Abstract
Extrauterine growth restriction (EUGR), a serious risk that potentially impairs the growth of preterm infants after birth and during childhood, triggers a thought of how to achieve optimal catch-up growth during hospitalization.We aimed to access the incidence of optimal catch-up growth in small-for-gestational-age (SGA), appropriate-for-gestational age (AGA) and large-for-gestational-age (LGA) infants, and identify the factors for optimal catch-up growth in preterm infants during hospitalization. Premature infants admitted to Shanghai Children’s Medical Center within 24 hours after birth from January 1,2016 to December 31, 2018 were enrolled. Prenatal, neonatal etiological, and nutrition data were collected and analyzed to identify factors associated with optimal catch-up growth during hospitalization. 105 (9.9%) of 1065 preterm newborns achieved predischarge optimal catch-up growth, including 27 (17.2%) of 157 SGA, 74 (8.5%) of 868 AGA, and 4 (10.0%) of 40 LGA infants. Logistic regression analysis indicated SGA, avoiding BPD and less days to regain birth weight as the contributing factors of optimal catch-up growth during hospitalization.Conclusion: SGA infants showed greater potential in predischarge optimal catch-up growth. Early abundant nutrition and avoiding BPD are essential for achieving optimal catch-up growth during hospitalization.
Modeling the Effects of the Factors Affecting IGF in Coastal Areas and Variation of IGF in Jiaodong Peninsula of China Based on Finite Element Method
Authors: Chu Hong-Xu , Xing Zan-Yang , Wang Yan-Ling , Nanan Balan , Zhang Qing-He , Liang Li-Kai , Wang Han 
Published: November 2021

Abstract
Based on finite element method, we develop a model of the induced geoelectric field (IGF) occurring in land-sea boundary regions during large geomagnetic field disturbances. The model is used first to study the effects of the changes in the lithospheric conductivity, ionospheric current, and ocean depth on the distribution of IGF in a typical land-sea boundary region. The results show that the changes in the lithospheric conductivity and ionospheric current (frequency, magnitude and direction) have major effects and ocean depth has minor effect on IGF in coastal areas. Then by incorporating a realistic 3-D conductivity variation of Jiaodong Peninsula (JDP) in China obtained from measured data, the model is used to simulate the IGF variation in JDP covering its land-sea boundaries for east-west and north-south ionospheric currents. The results show a new aspect that extremely large IGF development on the land side of the coastal bay areas perpendicular to the currnet compared to plane coastal areas. The results can stimulate detailed investigations of IGF (and GIC, geomagnetically induced current) in coastal areas.