bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometric properties of the original and short Hungarian version of the Iowa infant feeding attitude scale
Authors: Ungváry Renáta , Ittzés András , Bóné Veronika , Török Szabolcs 
Published: July 2021

Abstract
Background
The Iowa Infant Feeding Attitude Scale (IIFAS) is a widely used tool to assess attitudes towards infant feeding. Attitudes towards breastfeeding are one of the main influencing factors of feeding choice and breastfeeding duration. Adaptation of the IIFAS to the Hungarian context provides an opportunity for cross-cultural comparisons and helps to target breastfeeding support interventions. The growing number of shortened scales in various fields of research, demonstrates the necessity to adapt to a changing context of data collection to avoid fatigue and dropout among respondents. However, international comparisons are difficult due to the lack of a consensual shortened form of the scale.
The aim of our study was to examine the psychometric properties of the Hungarian version of the IIFAS (IIFAS-H) and propose an 8-item short version that has appropriate construct validity.

Methods
The original IIFAS was translated into Hungarian and then translated back to English. A cross-sectional study based on an internet survey in 2019 was conducted among 553 mothers whose most recent child’s age was between 6 and 36 months. Psychometric properties of the Hungarian IIFAS were determined and compared with international results. In order to obtain a shorter version of the Hungarian scale, we preferably kept those items that are common with other international abbreviated IIFAS versions and deleted items with a corrected item-total correlation or factor loading of less than 0.3, where factor loadings came from a principal component analysis forcing the extraction of one principal component (factor).

Results
The 17-item IIFAS-H showed good psychometric properties with a Cronbach’s alpha of0.73. Further analyses proved that the examined three shortened versions of the IIFAS consisting of 11, 9, and 8 items also showed good properties (Cronbach’s alpha = 0.79, 0.79, 0.76, respectively).

Conclusions
The Hungarian version of the original 17-item long IIFAS proved to be a good measurement tool with good psychometric properties. Based on our analyses, we suggest the use of the 8-item short version (IIFAS-H8) of the scale.
Gene therapies and COVID-19 vaccines: a necessary discussion in relation with viral vector-based approaches
Authors: Aledo-Serrano Angel , Gil-Nagel Antonio , Isla Julian , Mingorance Ana , Mendez-Hermida Fernando , Hernandez-Alcoceba Ruben 
Published: July 2021

AbstractThe COVID-19 pandemic is adding an unanticipated concern for those affected by genetic diseases. Most of the new treatment achievements for these patients are made possible as a result of advances in viral-based products. Among them, adenoviruses (AdV) and especially adeno-associated viruses (AAV) are important players. The concerns and the conversation around this issue have increased as COVID-19 vaccines approach the market. What if the viral vectors become the mainstream strategy for vaccine development? Will the immune response elicited against the vector compromise the efficacy of future gene therapies? Patients with genetic diseases and patient advocacy groups are requesting information to the medical community about the potential impact of these vaccines in future gene therapy treatments, and physicians and scientists are not able to provide satisfactory answer yet. Importantly, the frequency of cross-reactivity among different AAV serotypes can be as high as 50%. This would have potential implications for patients with genetic disorders who could benefit from gene therapies, often coming in the form of AAV-based gene therapies. As in many other aspects, this pandemic is challenging our capacity to coordinate, plan ahead and align different medical objectives. In this case, having such conversation early on might allow us to make the right choices while we are still on time.
Circular RNA circ_001422 promotes the progression and metastasis of osteosarcoma via the miR-195-5p/FGF2/PI3K/Akt axis
Authors: Yang Bingsheng , Li Lutao , Tong Ge , Zeng Zhirui , Tan Jianye , Su Zexin , Liu Zhengwei , Lin Jiezhao , Gao Wenwen , Chen Jianping , Zeng Sisi , Wu Guofeng , Li Lin , Zhu Shuang , Liu Qiuzhen , Lin Lijun 
Published: July 2021

Abstract
Background
Circular RNAs (circRNAs) are involved in diverse processes that drive cancer development. However, the expression landscape and mechanistic function of circRNAs in osteosarcoma (OS) remain to be studied.

Methods
Bioinformatic analysis and high-throughput RNA sequencing tools were employed to identify differentially expressed circRNAs between OS and adjacent noncancerous tissues. The expression level of circ_001422 in clinical specimens and cell lines was measured using qRT-PCR. The association of circ_001422 expression with the clinicopathologic features of 55 recruited patients with OS was analyzed. Loss- and gain-of-function experiments were conducted to explore the role of circ_001422 in OS cells. RNA immunoprecipitation, fluorescence in situ hybridization, bioinformatics database analysis, RNA pulldown assays, dual-luciferase reporter assays, mRNA sequencing, and rescue experiments were conducted to decipher the competitive endogenous RNA regulatory network controlled by circ_001422.

Results
We characterized a novel and abundant circRNA, circ_001422, that promoted OS progression. Circ_001422 expression was dramatically increased in OS cell lines and tissues compared with noncancerous samples. Higher circ_001422 expression correlated with more advanced clinical stage, larger tumor size, higher incidence of distant metastases and poorer overall survival in OS patients. Circ_001422 knockdown markedly repressed the proliferation and metastasis and promoted the apoptosis of OS cells in vivo and in vitro, whereas circ_001422 overexpression exerted the opposite effects. Mechanistically, competitive interactions between circ_001422 and miR-195-5p elevated FGF2 expression while also initiating PI3K/Akt signaling. These events enhanced the malignant characteristics of OS cells.

Conclusions
Circ_001422 accelerates OS tumorigenesis and metastasis by modulating the miR-195-5p/FGF2/PI3K/Akt axis, implying that circ_001422 can be therapeutically targeted to treat OS.
Prediction of combination therapies based on topological modeling of the immune signaling network in multiple sclerosis
Authors: Bernardo-Faura Marti , Rinas Melanie , Wirbel Jakob , Pertsovskaya Inna , Pliaka Vicky , Messinis Dimitris E. , Vila Gemma , Sakellaropoulos Theodore , Faigle Wolfgang , Stridh Pernilla , Behrens Janina R. , Olsson Tomas , Martin Roland , Paul Friedemann , Alexopoulos Leonidas G. , Villoslada Pablo , Saez-Rodriguez Julio 
Published: July 2021

Abstract
Background
Multiple sclerosis (MS) is a major health problem, leading to a significant disability and patient suffering. Although chronic activation of the immune system is a hallmark of the disease, its pathogenesis is poorly understood, while current treatments only ameliorate the disease and may produce severe side effects.

Methods
Here, we applied a network-based modeling approach based on phosphoproteomic data to uncover the differential activation in signaling wiring between healthy donors, untreated patients, and those under different treatments. Based in the patient-specific networks, we aimed to create a new approach to identify drug combinations that revert signaling to a healthy-like state. We performed ex vivo multiplexed phosphoproteomic assays upon perturbations with multiple drugs and ligands in primary immune cells from 169 subjects (MS patients, n=129 and matched healthy controls, n=40). Patients were either untreated or treated with fingolimod, natalizumab, interferon-β, glatiramer acetate, or the experimental therapy epigallocatechin gallate (EGCG). We generated for each donor a dynamic logic model by fitting a bespoke literature-derived network of MS-related pathways to the perturbation data. Last, we developed an approach based on network topology to identify deregulated interactions whose activity could be reverted to a “healthy-like” status by combination therapy. The experimental autoimmune encephalomyelitis (EAE) mouse model of MS was used to validate the prediction of combination therapies.

Results
Analysis of the models uncovered features of healthy-, disease-, and drug-specific signaling networks. We predicted several combinations with approved MS drugs that could revert signaling to a healthy-like state. Specifically, TGF-β activated kinase 1 (TAK1) kinase, involved in Transforming growth factor β-1 proprotein (TGF-β), Toll-like receptor, B cell receptor, and response to inflammation pathways, was found to be highly deregulated and co-druggable with all MS drugs studied. One of these predicted combinations, fingolimod with a TAK1 inhibitor, was validated in an animal model of MS.

Conclusions
Our approach based on donor-specific signaling networks enables prediction of targets for combination therapy for MS and other complex diseases.
Incidence of anterior uveitis in patients with axial spondyloarthritis treated with anti-TNF or anti-IL17A: a systematic review, a pairwise and network meta-analysis of randomized controlled trials
Authors: Roche Damien , Badard Martin , Boyer Laurent , Lafforgue Pierre , Pham Thao 
Published: July 2021

Abstract
Background
Anterior uveitis (AU) is the most frequent extra-articular feature of axial spondyloarthritis (axSpA). We aimed to assess and compare the incidence of AU in axSpA patients treated with anti-TNF or anti-IL17A.

Methods
We systematically reviewed PubMed, EMBase, and Cochrane from inception to May 3, 2020, and searched for placebo-controlled and head-to-head randomized controlled trials (RCTs) assessing anti-TNF monoclonal antibodies (mAb) or soluble receptor fusion protein or anti-IL17A in patients with axSpA according to ASAS criteria and reporting safety data on AU. Data were extracted following a predefined protocol. We did pairwise and network meta-analyses for the primary outcome of AU flares (relapse or de novo) incidence and estimated summary odds ratios (ORs). We assessed the quality of evidence using the Cochrane risk-of-bias 2.0 tool. We ranked treatments according to their effectiveness in preventing AU flare using the P-score.

Results
We identified 752 citations and included 33 RCTs, comprising 4544 treated patients (anti-TNF mAb 2101, etanercept [ETN] 699, anti-IL17A 1744) and 2497 placebo-receiving patients. Incidence of uveitis was lower with anti-TNF mAb versus placebo (OR = 0.46; CI 95% [0.24; 0.90]) and versus anti-IL17A (OR = 0.34; CI 95% [0.12; 0.92]. According to the P-score, the ranking from the most to the least preventive treatment of uveitis flare was as follows: anti-TNF mAb, ETN, placebo, and anti-IL17A.

Conclusion
In RCTs assessing anti-TNF and anti-IL17A in axSpA, incident uveitis are rare events. However, this network meta-analysis demonstrates that anti-TNF mAb are associated with a lower incidence of uveitis compared to placebo and anti-IL17A.
The dynamics of a Leslie type predator–prey model with fear and Allee effect
Authors: Vinoth S. , Sivasamy R. , Sathiyanathan K. , Unyong Bundit , Rajchakit Grienggrai , Vadivel R. , Gunasekaran Nallappan 
Published: July 2021

AbstractIn this article, we discuss the dynamics of a Leslie–Gower ratio-dependent predator–prey model incorporating fear in the prey population. Moreover, the Allee effect in the predator growth is added into account from both biological and mathematical points of view. We explore the influence of the Allee and fear effect on the existence of all positive equilibria. Furthermore, the local stability properties and possible bifurcation behaviors of the proposed system about positive equilibria are discussed with the help of trace and determinant values of the Jacobian matrix. With the help of Sotomayor’s theorem, the conditions for existence of saddle-node bifurcation are derived. Also, we show that the proposed system admits limit cycle dynamics, and its stability is discussed with the value of first Lyapunov coefficient. Moreover, the numerical simulations including phase portrait, one- and two-parameter bifurcation diagrams are performed to validate our important findings.
Tropospheric dispersive phase anomalies during heavy rain detected by L-band InSAR and their interpretation
Authors: Setiawan Naufal , Furuya Masato 
Published: July 2021

AbstractThe split-spectrum method (SSM) can largely isolate and correct for the ionospheric contribution in the L-band interferometric synthetic aperture radar (InSAR). The standard SSM is performed on the assumption of only the first-order ionospheric dispersive effect, which is proportional to the total electron content (TEC). It is also known that during extreme atmospheric events, either originated from the ionosphere or in the troposphere, other dispersive effects do exist and potentially provide new insights into the dynamics of the atmosphere, but there have been few detection reports of such signals by InSAR. We apply L-band InSAR into heavy rain cases and examine the applicability and limitation of the standard SSM. Since no events such as earthquakes to cause surface deformation took place, the non-dispersive component is apparently attributable to the large amount of water vapor associated with heavy rain, whereas there are spotty anomalies in the dispersive component that are closely correlated with the heavy rain area. The ionosonde and Global Navigation Satellite System (GNSS) rate of total electron content index (ROTI) map both show little anomalies during the heavy rain, which suggests few ionospheric disturbances. Therefore, we interpret that the spotty anomalies in the dispersive component of the standard SSM during heavy rain are originated in the troposphere. While we can consider two physical mechanisms, one is runaway electron avalanche and the other is the dispersive effect due to rain, comparison with the observations from the ground-based lightning detection network and rain gauge data, we conclude that the rain dispersive effect is spatiotemporally favorable. We further propose a formulation to examine if another dispersive phase than the first-order TEC effect is present and apply it to the heavy rain cases as well as two extreme ionospheric sporadic-E events. Our formulation successfully isolates the presence of another dispersive phase during heavy rain that is in positive correlation with the local rain rate. In comparison with other dispersive phases during Sporadic-E episodes, the dispersive heavy rain phases seem to have the same order of magnitude with the ionospheric higher order effects.
Forest management for optimizing soil protection: a landscape-level approach
Authors: Rodrigues Ana Raquel , Marques Susete , Botequim Brigite , Marto Marco , Borges José G. 
Published: July 2021

Abstract
Background
Soil erosion is still identified as the main cause of land degradation worldwide, threatening soil functions and driving several research and policy efforts to reverse it. Trees are commonly associated to some of the most successful land-use systems to achieve soil protection goals, but the extent to which forest ecosystems reduce erosion risks can largely depend on management decisions and associated silvicultural practices. Optimization tools can assist foresters in solving the complex planning problem they face, concerning the demand for different, and often conflicting, ecosystem services. A resource capability model (RCM), based on a linear programming approach, was built and solved for a forest landscape management problem in Northwest Portugal, over a 90-years planning horizon, divided in 10-years periods.

Results
Timber provision and soil erosion were found to be in trade-off. The management alternatives included in the model were proven to be sufficiently flexible to obtain the desired level of timber yield, both in volume and even distribution along the planning horizon, while ensuring lower levels of soil loss estimates (below 35 Mg∙ha− 1∙year− 1). However, under climate change conditions, compatible with an increasing greenhouse gases emission scenario, potential landscape soil erosion may be enhanced up to 46 Mg∙ha− 1∙year− 1 in critical periods.

Conclusions
Soil conservation concerns in landscape-level forest management planning can be addressed by LP-based optimization methods. Besides providing an optimal management solution at landscape level, this approach enables a comprehensive analysis of the RCM, possible trade-offs and potential changes towards uncertainties.
Metabolism and biomarkers of heterocyclic aromatic amines in humans
Authors: Bellamri Medjda , Walmsley Scott J. , Turesky Robert J. 
Published: July 2021

AbstractHeterocyclic aromatic amines (HAAs) form during the high-temperature cooking of meats, poultry, and fish. Some HAAs also arise during the combustion of tobacco. HAAs are multisite carcinogens in rodents, inducing cancer of the liver, gastrointestinal tract, pancreas, mammary, and prostate glands. HAAs undergo metabolic activation by N-hydroxylation of the exocyclic amine groups to produce the proposed reactive intermediate, the heteroaryl nitrenium ion, which is the critical metabolite implicated in DNA damage and genotoxicity. Humans efficiently convert HAAs to these reactive intermediates, resulting in HAA protein and DNA adduct formation. Some epidemiologic studies have reported an association between frequent consumption of well-done cooked meats and elevated cancer risk of the colorectum, pancreas, and prostate. However, other studies have reported no associations between cooked meat and these cancer sites. A significant limitation in epidemiology studies assessing the role of HAAs and cooked meat in cancer risk is their reliance on food frequency questionnaires (FFQ) to gauge HAA exposure. FFQs are problematic because of limitations in self-reported dietary history accuracy, and estimating HAA intake formed in cooked meats at the parts-per-billion level is challenging. There is a critical need to establish long-lived biomarkers of HAAs for implementation in molecular epidemiology studies designed to assess the role of HAAs in health risk. This review article highlights the mechanisms of HAA formation, mutagenesis and carcinogenesis, the metabolism of several prominent HAAs, and the impact of critical xenobiotic-metabolizing enzymes on biological effects. The analytical approaches that have successfully biomonitored HAAs and their biomarkers for molecular epidemiology studies are presented.
Is fast-food consumption a problem among adolescents in Malaysia? An analysis of the National School-Based Nutrition Survey, 2012
Authors: Man Cheong Siew , Hock Lim Kuang , Ying Chan Ying , Cheong Kee Chee , Kuay Lim Kuang , Huey Teh Chien , Baharudin Azli , Aziz Nur Shahida Abdul 
Published: July 2021

Abstract
Background
Fast-food consumption is an unhealthy dietary behaviour because it increases the risk of diet-related chronic diseases. We aimed to investigate factors associated with fast-food consumption, namely sociodemographic characteristics, body mass index-for-age, meal away from home habit, and intake of various food groups among adolescents in Malaysia.

Methods
We analysed data from the National School-Based Nutrition Survey (NSNS). The NSNS was a nationwide, cross-sectional survey. Multiple-stage stratified cluster random sampling method was applied to obtain a representative sample of adolescents’ population. This study recruited adolescents aged 10–18 years who were attending schools. Pre-tested self-administered questionnaires in Malay language were used to obtain relevant information. Frequency of fast-food consumption per week was classified into three groups: “consumed fast-food four to seven days”, “consumed fast-food one to three days”, and “did not consume fast-food”. Intake of food groups was assessed by self-administered food frequency questionnaire. Descriptive and complex sample multinomial logistic regression analyses were performed in data analysis.

Results
A total of 26,383 from 40,012 selected adolescents completed all the relevant questions for this study. Of those surveyed, 13.5% of the respondents consumed fast-food 4 to 7 days, 69.3% of the respondents consumed fast food 1 to 3 days, and 17.2% of them did not consume fast-food in a typical week. Frequency of fast-food consumptions (4 to 7 days and 1 to 3 days per week) was significantly associated with age; sex; ethnicity; locality of schools; frequency of eating out; and not consuming recommended intake of cereals or grains, vegetables, and meat or poultry or eggs.

Conclusion
In conclusion, age; sex; ethnicity; locality of schools; frequency of eating out per week; imbalanced intake of cereals or grains, meat, or poultry or eggs; and inadequate vegetable intake were significantly associated with fast-food consumption among adolescents in Malaysia. The findings of this study will be useful for policy makers in promoting healthy food choices among adolescents in Malaysia.
Analysis of outcomes of endovascular embolisation: A cross-sectional two-center study on 46 visceral artery pseudoaneurysms
Authors: Omar Mohammad Koriem Mahmoud , Othman Moustafa H M , Morgan Robert , Abdallah Abdelkarem Hasan , Seif Hany , Zidan Mohamed , Khairallah Mahmoud , El-Aleem Reham Abd 
Published: July 2021

Abstract
Purpose
Visceral artery pseudoaneurysms (VAPAs) are uncommon in clinical practice but may have serious clinical outcomes up to death. Endovascular management is a safe effective alternative option to traditional surgical procedures. This study assesses the outcome of different embolic materials and techniques used in the endovascular management of VAPAs.

Materials and methods
This is a two-center retrospective analysis of endovascular embolisation of 46 VAPAs, with a mean pseudoaneurysm size of 13 ± 11.35 mm, that were urgently managed between July 2018 and March 2020. Patients’ presentations were GIT hemorrhage, intrabdominal hemorrhage, hematuria, and abdominal pain in 34.78%, 30.43%, 23.91%, and 10.87% respectively. Management using coils only was done in 28/46 patients (60.87%), NBCA glue only in 16/46 patients (34.78%), combined coils and NBCA glue in 1/46 patient (2.17%), and Amplatzer plugs only in 1 patient (2.17%). The management techniques were sac packing in 9/46 patients (19.57%), inflow occlusion in 28/46 patients (60.87%) and trapping in 9/46 patients (19.57%). All patients were followed-up for 1 year after the procedure.

Results
The overall clinical success and periprocedural complication rates were 93.48%, and 15.22% respectively, and 30-day mortality was zero. Clinical success was 92.86% in the coil subgroup (n = 28), and 93.75% in the NBCA glue subgroup (n = 16). The technical success rate was 100%. Effectiveness of the procedures during the follow-up was 97.83%. Target lesion re-intervention rate was 2.17%.

Conclusion
Transarterial embolisation can provide high technical and clinical success rates with low periprocedural complication and re-intervention rates, as well as satisfactory procedure effectiveness in the management of VAPAs.