bluuebunny/crossref_metadata_2025_split huggingface dataset:
Public Health Ethics in Covid-19 Scenario
Authors: Giripunje Pranay 
Published: February 2021

Due to the pandemic, authorities of India followed public health measures to include its unfold within the India. a number of measures were imposed on public like obligatory home and institution quarantine, and social distancing. Although it being a public fitness emergency, the measures observed required crucial appraisal and use of an ethics and human rights technique. The goal of paper is to give an ethics and human rights standards to compare public fitness measures and use it to reflect on the ethical sides of these adopted through the authorities of India to consist of the unfold of pandemic.
first we discuss all the measure taken for ethics in the human rights concerns for public and their fitness measures with all the emergencies. We then brief India’s social and economic conditions and some of the measures followed to include the unlock of pandemic. After that, some moral duty of some of India’s responses to pandemic. We then do evaluation to discover the measures adopted by the authorities of India to slow the spread of pandemic, the ethics and human rights issues typically given for public health responder . we analysed that some of the measures violated ethics and human rights ideas. despite the fact that a some human rights can on occasion be legitimately lowered and constrained to meet public fitness dreams at some stage in public fitness emergencies, measures that infringe on human rights have to fulfil positive way of ethics and human rights standards. Other of the ones requirements i being powerful, strictly critical, proportionate to the value of the danger, questionable in the conditions, least restrictive. We tell about India’s primary measures to fight the pandemic and tell that a variety of them fell incomplete of those criteria, and were not effective at all.
Overview of therapeutic options in COVID-19
Authors: Dr. Swarupa Chakole Sarthak Katyal, 
Published: February 2021

Coronavirus is essentially a respiratory sickness brought about by a newfound rSARS-CoV-2 infection and distinguished in the city of Wuhan, China in December 2019. The emerging outbreak of Covid disease 2019 (COVID-19) brought about because ofthe severe respiratory disorder Covid 2 (SARS-CoV-2) presents a phenomenal test for medical services frameworks around the world.WHO has proclaimed this illness as a pandemic, and cautioned different nations. Like other Covids, this may create respiratory plot contaminations in the patients range from gentle to lethal ailment like pneumonia and ARDS(acute respiratory distress syndrome).The features of coronavirus and the capacity to quickly make far reaching contamination has significant ramifications, justifying vivacious disease avoidance and the preventive measures. While the affirmed quantity of the cases have outperformed 10.3 million throughout the world and keeps on developing, as the possible seriousness related to infection along with its destructive confusions needs critical advancement of the novel restorative specialists to both forestall and cure the COVID-19 illness . In spite of the fact that antibodies and explicit medication treatments presently can't seem to be found, progressing investigation and subjective preliminaries have led to the examination of viability of the reused medications for curing COVID-19 illness .According to the current audit, some of the medication competitors have been recommended to cure COVID-19 will be talked about. While these incorporate enemy of the viral specialists (remdesivir ,rebetol, lopinavir-ritonavir,choloroquine, favipiravir, hydroxychloroquine, umifenovir ,oseltamivir,), immunomodulating based specialists (interferons, plasma bondings , tocilizumab), (azithromycin, corticosteroids), along with other random specialists. With components of activity and further pharmacology based property which should be investigated, within a specific spotlight on the proof base wellbeing with viability of a every specialist.
Covid-19 – Lockdown Efficacy in Different Countries
Authors: Dr. Swaroopa Chakole Shaik Sarwar Allam, 
Published: February 2021

BACKGROUND
COVID-19 or coronavirus disease 2019 is seriously affecting the day-to-day life of all the people on the planet. To add to the woes more virulent mutated strain has been discovered and more study is being carried out.
SUMMARY
Treating COVID-19 is a challenge in itself as the containment is tough due to high spreading capacity and its deadly nature. The initial phase of the disease has taken aback almost all the countries due to its high virulent nature. Therefore, blanket measures like lockdown and physical distancing were adopted by different countries after the COVID-19 was declared as pandemic by WHO. Various studies on its efficacy has been done and more needs to be done in order to obtain holistic approach.
CONCLUSION
Lockdown as a preventive measure during COVID-19 pandemic was proved to be effective in containing the viral spread. But only lockdown was not the only factor and other NPI’s was supplementing the containment measures. More study across the nation’s border is needed so that greater clarity can emerge from the datasheet.
Preventive Measures for Health Professionals in COVID-19
Authors: Dr. Swaroopa Chakole Subhendu Pradhan, 
Published: February 2021

BACKGROUND
COVID-19 or coronavirus disease 2019 is affecting all inhabitants on the earth and most affected section of the society which is also a crucial aspect of the mitigation measures is health care professionals.
SUMMARY
COVID-19 or coronavirus disease 2019 is raging across the world with increasing number of infected cases and associated case fatalities. Health care professionals are among worst hit section and several of them laid their live in the line of duty of COVID-19 mitigation. It is therefore importantto safeguard them through this pandemic and ensure proper care of them is taken.
CONCLUSION
Best practices must be followed in order to ensure the safety of the front-line workers such as doctors and allied health care givers. More study can be done to broaden the base of available empirical data of factors affecting the safety of them.
Perceptions about COVID-19 and their Myths and Belief: The Need to Provide Knowledge and Guidance to Public.
Authors: Dr. Swarupa Chakole Tejas H. L. Kawre, 
Published: February 2021

Background: Efforts to promote COVID-19 will actually be in vain without a proper understanding of the perceptions and beliefs that prevail in society. That is why this study sought to identify the gaps in Ethiopia about COVID-19 false interpretation and lack of knowledge.Methods: A survey was conducted online in Ethiopia from 22 April to 4 May 2020. The connection to the questionnaire were announced via email, digital media and the Jimma University website. The perception of COVID-19 was based on World Health Organisation (WHO) sources and knowledge. The Statistical Package for the Social Sciences (SPSS) version 20.0 software was used to analyse the data. A list of categories and factors was developed for facilitators' perceptions, barriers and information needs. An explanatory factor analysis (EFA) was conducted to support the categorization. Standardized category means were compared using analysis of variance (ANOVA) and t-test. The p<0.05 value and significant differences were claimed as they were supposed to be taken as the very result of this article and further discussed in a manner of strategy to identify the false belief and superstitions regarding COVID-19.Inference: The assumption that youth are at minimal chance of contracting COVID-19 requires continuous monitoring and attention. Communication chances and social participation activities need to take into account local and community variations in misbelief and fake assurances. Local efforts must be designed to meet source needs and increase community ownership of anti-viral measures, and should support efforts to address standard precautions. Various methods of communication must be used and appropriately understood to make out the misbelief and fake information.
The Effect of Mental Fatigue on Half-Marathon Performance: a Pragmatic Trial
Authors: Gattoni Chiara , O’Neill Barry Vincent , Schena Federico , Marcora Samuele Maria 
Published: February 2021

Abstract
Purpose It is well established that mental fatigue impairs performance during lab-based endurance tests lasting < 45 min. However, the effects of mental fatigue on longer-duration endurance events and in field settings are unknown. The aim of this study was to investigate the effect of mental fatigue on performance during a half-marathon race.Methods Forty-six male amateur runners (means ± SD: age 43.8 ± 8.6 years, V̇O2max 46.0 ± 4.1 ml/kg/min) completed an half-marathon after being randomly allocated to performing a 50-min mentally-fatiguing task (mental fatigue group) or reading magazines for 50 min (control group). Running speed, heart rate, and perceived effort were measured during the race.Results The mental fatigue group completed the half-marathon approximately four minutes slower (106.2 ± 12.4 min) than the control group (102.4 ± 10.2 min), but this difference was not statistically significant (Cohen’s d = 0.333; p = 0.265). However, equivalence was not established (t(40.88) = 0.239, p = 0.594) and equivalence testing analysis excluded a worthwhile positive effect of mental fatigue on half-marathon performance.Conclusion Due to its posttest-only design and the achievable sample size, the study did not have enough power to provide evidence that the observed 4-minute increase in half-marathon time is statistically significant. However, equivalence testing suggests that mental fatigue has no beneficial effects on half-marathon performance in male amateur runners, and harmful effects cannot be excluded. Overall, it seems prudent for endurance athletes to avoid mentally-fatiguing tasks before competitions.
Fine Mapping and Candidate Gene Analysis of a Major Locus Controlling Ovule Abortion and Seed Number Per Silique in Brassica Napus L.
Authors: Jiao Yangmiao , Zhang Kunpeng , Cai Guangqin , Yu Kaidi , Amoo Olalekan , Han Shaoqing , Zhao Xiang , Zhang Hao , Hu Limin , Wang Bingrui , fan chuchuan , Zhou Yongming 
Published: February 2021

Abstract
Key message A major QTL controlling ovule abortion and SN was fine-mapped to a 80.1-kb region on A8 in rapeseed, and BnaA08g07940D and BnaA08g07950D are the most likely candidate genes.Abstact The seed number per silique (SN), an important yield determining trait of rapeseed, is the final consequence of a complex developmental process including ovule initiation and the subsequent ovule/seed development. To elucidate the genetic mechanism regulating the natural variation of SN and its related components, quantitative trait locus (QTL) mapping was conducted using a doubled haploid (DH) population derived from the cross between C4-146 and C4-58B, which showed signiﬁcant differences in SN and aborted ovule number (AON), but no obvious differences in ovule number (ON). QTL analysis identiﬁed 19 consensus QTLs for six SN-related traits across three environments. A novel QTL on chromosome A8, un.A8, which pleiotropically controls all these traits except for ON, was stably detected across the three environments.This QTL explained more than 50% of the SN, AON and percentage of aborted ovule (PAO) variations as well as a moderate contribution on silique length (SL) and thousand seed weight (TSW). The C4-146 allele at the locus increases SN and SL but decreases AON, PAO and TSW. Further fine mapping narrowed down this locus into a 80.1-kb interval flanked by markers BM1668 and BM1672, and six predicted genes were annotated in the delimited region. Expression analyses and DNA sequencing showed that two homologs of Arabidopsis photosystem I subunit F (BnaA08g07940D) and zinc transporter 10 precursor (BnaA08g07950D) were the most promising candidate genes underlying this locus. These results provide a solid basis for cloning un.A8 to reduce the ovule abortion and increase SN in the yield improvement of rapeseed.
Bioinformatics Analysis in Different Expression Genes and Potential Pathways of CD4+ Cells in Childhood Allergic Asthma
Authors: Li Chenbei , Kan Ao , Zeng Xianjun 
Published: February 2021

Abstract
Background: Asthma is one of the most common chronic respiratory diseases in children. CD4+T cell plays a key role in the immune response which affects the pathogenesis of asthma. Genetic level of CD4+T cells on childhood allergic asthma remains unclear. In our study, we aimed to identify potential different expressed genes (DEGs) and pathways related to childhood allergic asthma by performing bioinformatics analysis of dataset.Methods: GSE40887 dataset from Gene Expression Omnibus (GEO) was used for bioinformatics analysis. Limma package in R was used to detect DEGs. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were carried by Database for Annotation, Visualization and Integrated Discovery (DAVID). The construction of protein-protein interaction (PPI) network of the DEGs was performed by Search Tool for the Retrieval of Interacting Genes (STRING) and Cytoscape. Hub genes were identified through cytoHubba in Cytoscape. Results: In all, 200 up-regulated genes and 69 down-regulated genes were identified. Up-regulated genes were mainly enriched in: protein self-association, cellular response to hydrogen peroxide, plasma membrane. As for down-regulated genes, enzyme binding and detection of chemical stimulus involved in sensory perception of smell, nucleolus were enriched. Only one KEGG pathway was enriched: olfactory transduction. In addition, top 10 hub genes were found including: PRPF19, CCAR1, CWC15, PRPF38A, PRCC, KRR1, RPS3, PDCD11, MKI67, and NUF2. Conclusion: Several DEGs (SNORD46, RPS3, OR5E1P, OR56A5 and OR51B6, and PDCD11), one pathway (olfactory transduction) and one biological process (cellular response to hydrogen peroxide) were found might associate to childhood allergic asthma. Our results may provide inspiration for other researchers on DEGs and pathways in CD4+T cells of childhood allergic asthma.
Apolipoprotein C-II induces EMT to Promote Gastric Cancer Peritoneal Metastasis via PI3K/AKT/mTOR Pathway
Authors: Wang Chao , Yang Zhi , Xu En , Wang Xingzhou , Li Zijian , Yu Heng , Chen Kai , Liu Song , Guan Wenxian 
Published: February 2021

Abstract
Background: Peritoneal metastasis (PM) occurs frequently in patients with gastric cancer (GC) and confers poor survival. Lipid metabolism and epithelial-mesenchymal transition (EMT) play an important role in GC metastasis. As Apolipoprotein C-II (APOC2) is a key protein in lipid metabolism, few studies have investigated the role of APOC2 in PM. This study aims to elucidate the potential molecular mechanism of APOC2 in the PM of GC.Methods: The Tandem Mass Tagging (TMT) method followed by liquid chromatography-tandem mass spectrometry-based proteomics analysis was used to compare the levels of differentially expressed proteins between human PM and GC tissues. APOC2 expression was evaluated by immunoblotting, and immunohistochemistry analysis (n = 111). APOC2 over-expression and knock-down expression cell models were developed and tested in vitro. RNA sequencing analysis evaluated the changes in gene expression after APOC2 knockdown in GC cells. The Agilent Seahorse XF platform and lipid staining assay were used to evaluate the role of APOC2 in lipid metabolism of GC cells. Spheroid cell invasion assay, apoptosis assay, colony formation assay, wound-healing assays, and transwell assays were performed and peritoneal implants into nude mice were done to assess the biological effects of APOC2. The underlying mechanisms were investigated using Western blot, inhibitor or activator treatment assays.Results: APOC2 was highly abundant in GC cells and PM tissues. And high APOC2 levels in GC tissues correlated with poor patient prognosis. Knockdown of APOC2 inhibited the malignant phenotype of cancer cells and EMT significantly. Massive gene expression alterations after APOC2 knockdown, which were associated with various signaling pathways, especially the PI3K/AKT signaling pathway and lipid metabolism. Furthermore, the regulatory effects of APOC2 on the EMT were partially attributed to the PI3K/AKT/mTOR signaling pathway. The results in vivo also showed that APOC2 modulated GC PM.Conclusions: We verified that knockdown of APOC2 suppressed GC cell Lipid metabolism, proliferation, migration, invasion, and EMT, accompanied by inactivation of PI3K/AKT/mTOR signaling pathway. APOC2 overexpression had the opposite effects GC cell phenotypes and mechanisms. Collectively, our results identified APOC2 in PM as a potential therapeutic target.
Removal of Methylene Blue Dye From Aqueous Solution Using PDADMAC Modified ZSM-5&nbsp;Zeolite as a Novel Adsorbent&nbsp;
Authors: Radoor Sabarish , Karayil Jasila , Jayakumar Aswathy , Parameswaranpillai Jyotishkumar , Siengchin Suchart 
Published: February 2021

Abstract
In the present work, we modified ZSM-5 zeolite using a bio polymer poly (diallyl dimethyl ammonium chloride) and employed it for the removal of cationic dye, methylene blue from aqueous solution. The chemical and physical properties of the modified ZSM-5 zeolite were investigated using XRD, FTIR, SEM, TEM, nitrogen adsorption, TGA and 27Al NMR. Modified ZSM-5 zeolite possesses high surface area and pore diameter which was confirmed from SEM, TEM and nitrogen adsorption analysis. Adsorption of methylene blue on zeolite was investigated by batch adsorption technique. The effect of different parameters such as zeolite dosage, initial methylene blue concentration, temperature, pH and contact time on the adsorption process was discussed. Maximum adsorption capacity (4.31 mg/g) was achieved using 0.1g of modified ZSM-5 zeolite at the optimum conditions (initial dye concentration: 10 mg/L, pH: 10, temperature:30oC and contact time: 300 min). The experimental data were fitted into Langmuir and Freundlich models and the results indicate that the adsorption process followed Freundlich isotherm. Kinetic data were investigated using pseudo-first-order and pseudo-second-order models. Kinetic analysis indicates that pseudo-second-order model is more suitable to describe adsorption of MB on modified ZSM-5 zeolite. The reusability test suggests that the adsorbent could be reused at least six times without significant loss in removal efficiency.
Climate Transition From Warm-dry to Warm-wet in Eastern Northwest China
Authors: Yang Jinhu , Zhang Qiang , Lu Guoyang , Liu Xiaoyun , Wang Youheng , Wang Dawei , Liu Weiping , Yue Ping , Zhu Biao 
Published: February 2021

Abstract

During the second half of the 20th century, eastern Northwest China experienced a warming and drying climate change. To determine whether this trend has continued or changed during the present century, this study systematically analyzes the characteristics of warming and dry–wet changes in eastern Northwest China based on the latest observational data and World Climate Research Programme (WCRP) Coupled Model Intercomparison Project Phase 6 (CMIP6) collection data. The results show that eastern Northwest China has warmed continuously during the past 60 years with a sudden temperature change occurring in the late 1990s. However, the temperature in the 2000s decreased slowly, and that in the 2010s showed a warming trend. The amount of precipitation began to increase in the late 1990s, which indicates a contemporary climate transition from warm-dry to warm-wet in eastern Northwest China. The contribution of precipitation to humidity is significantly more than that of temperature. Long-term and interannual variations dominate the temperature change, with the contribution of the former much stronger than that of the latter. However, interannual variation dominates the precipitation change. The warming accelerates from period to period, and the temperature spatial consistently increased during the three most recent climatic periods. The precipitation decreased from 1961–1990 to 1981–2010, whereas its spatial consistency increased from 1981–2010 to 1991–2019. The significant warming and humidification that began in the late 1990s and is expected to continue until the end of the 21st century in the medium emission scenario. However, the current sub-humid climate will not easily be changed. The warming could cause a climate transition from warm temperate to subtropical by 2040. The dry-to-wet climate transition in eastern Northwest China could be related to synergistic enhancement of the East Asian summer monsoon and the westerly circulation. This research provides a scientific decision-making basis for implementing western development strategies, ecological protection, and high-quality development of the Yellow River Basin Area as well as that for ecological construction planning and water resource management of eastern Northwest China.
Challenges of the Blue Economy: Evidence and Research Trends&nbsp;&nbsp;
Authors: Vázquez Rosa María Martínez , García Juan Milán , Valenciano Jaime de Pablo 
Published: February 2021

Abstract
BackgroundThe Blue Economy is a recent field of study that encompasses economic activities that depend on the sea, often associated with other economic sectors, including tourism, maritime transport, energy and fishing. Blue growth supports the sustainable growth of the maritime and marine sectors as the oceans and seas are engines of the global economy and have great potential for growth and innovation. This article undertakes a bibliometric analysis in the terms of blue economy, maritime economy, ocean economy, marine economy, and Blue Growth to analysis the scientific production of this field of study. The main objective is to find out if there is a link between the blue economy and the circular economy.ResultsThe results show an evolving and growing trend during the last decade regarding the number of published articles and citations. Nascent and future research trends include terms such as small-scale fisheries, blue degrowth, aquatic species, biofuel, growth of the coastal blue economy, and internationalization. New researchers, experts, public institutions, and private companies who wish to understand the roots of the Blue Economy and its evolution over time may find this article useful to design and develop strategies that lead to its efficient management, preservation, and sustainability.ConclusionsIn conclusion, it highlights the need for alliances between the sectors that compose blue growth with the incorporation of the circular economy in order to achieve a sustainable blue economy.