bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on discriminant method of rock type for porous carbonate reservoirs based on Bayesian theory
Authors: Fang Xinxin , Feng Hong 
Published: September 2021

AbstractRock typing is an extremely critical step in the estimation of carbonate reservoir quality and reserves in the Middle East. In order to recognize the rock types of carbonate reservoirs in the Mishrif Formation better, classify the reservoirs accurately, and establish the permeability model in line with the study area precisely, it is necessary to study the recognition method conforming to the actual situation of the study area. The practice shows that the current recognition methods based on capillary pressure curve, flow unit and NMR logging data can effectively distinguish rock types, but a large number of accurate experimental data are required, which can only be applied in a few cored well, however, cannot be applied in the whole oil field. In this study, based on core, thin section, logging data, the sedimentary characteristics of carbonate reservoir, logging response of four rock types as well as porosity and permeability characteristics of Mishrif Formation in W are comprehensively studied. Based on Bayesian stepwise discriminant theory in multivariate statistics, the Bayesian discrimination model based on conventional logging data is established. The examining results showed that, compared with the description of logging and coring, the accuracy of Bayesian discriminant model and cross confirmation rate have achieved more than 80% for the original sample. Reliability verification showed that the matching degree of the rock type recognized in the non-cored well with the core and mud logging was as high as 90%, which matched the depositional environment of the entire region. The study results confirm the validity and generalizability of the Bayesian method to identify and predict rock types, which can be applied to the entire Middle East region to solve the problem of the lack of core data to accurately evaluate the quality of non-cored wells and accurately predict production, meeting the needs of actual reservoir evaluation and production development in the Middle East.
Relative risk of functional dyspepsia in patients with sleep disturbance: a population-based cohort study
Authors: Su Hsu-Han , Sung Fung-Chang , Kao Kai-Liang , Chen Shu-Chin , Lin Chen-Ju , Wu Shu-I , Lin Cheng-Li , Stewart Robert , Chen Yi-Shin 
Published: September 2021

AbstractIncreased prevalence of sleep disorders has been found in patients with functional dyspepsia; however, direction of causality remains unclear. Our aim was to compare the risk of incident functional dyspepsia between patients with and without sleep disturbance from a large population-based sample. Utilizing a nation-wide health insurance administrative dataset, we assembled an 11-year historic cohort study to compare subsequent incidence of diagnosed functional dyspepsia between adult patients with any diagnosis of sleep disturbance and age- and gender-matched controls. Hazard ratios adjusted for other relevant comorbidities and medications were calculated using Cox regression models. 45,310 patients with sleep disorder and 90,620 controls were compared. Patients with sleep apnea had a 3.3-fold (95% confidence interval: 2.82 ~ 3.89) increased hazard of functional dyspepsia compared with controls. This increased risk persisted regardless of previously diagnosed depression coexisted. Sleep disturbance was associated with an increased risk of subsequent functional dyspepsia. Potential mechanisms are discussed.
Simulation studies on electrical characteristics of silicon nanowire feedback field-effect transistors with interface trap charges
Authors: Yang Yejin , Park Young-Soo , Son Jaemin , Cho Kyoungah , Kim Sangsig 
Published: September 2021

AbstractIn this study, we examine the electrical characteristics of silicon nanowire feedback field-effect transistors (FBFETs) with interface trap charges between the channel and gate oxide. The band diagram, I–V characteristics, memory window, and operation were analyzed using a commercial technology computer-aided design simulation. In an n-channel FBFET, the memory window narrows (widens) from 5.47 to 3.59 V (9.24 V), as the density of the positive (negative) trap charges increases. In contrast, in the p-channel FBFET, the memory window widens (narrows) from 5.38 to 7.38 V (4.18 V), as the density of the positive (negative) trap charges increases. Moreover, we investigate the difference in the output drain current based on the interface trap charges during the memory operation.
DEVOLUTION—A method for phylogenetic reconstruction of aneuploid cancers based on multiregional genotyping data
Authors: Andersson Natalie , Chattopadhyay Subhayan , Valind Anders , Karlsson Jenny , Gisselsson David 
Published: September 2021

AbstractPhylogenetic reconstruction of cancer cell populations remains challenging. There is a particular lack of tools that deconvolve clones based on copy number aberration analyses of multiple tumor biopsies separated in time and space from the same patient. This has hampered investigations of tumors rich in aneuploidy but few point mutations, as in many childhood cancers and high-risk adult cancer. Here, we present DEVOLUTION, an algorithm for subclonal deconvolution followed by phylogenetic reconstruction from bulk genotyping data. It integrates copy number and sequencing information across multiple tumor regions throughout the inference process, provided that the mutated clone fraction for each mutation is known. We validate DEVOLUTION on data from 56 pediatric tumors comprising 253 tumor biopsies and show a robust performance on simulations of bulk genotyping data. We also benchmark DEVOLUTION to similar bioinformatic tools using an external dataset. DEVOLUTION holds the potential to facilitate insights into the development, progression, and response to treatment, particularly in tumors with high burden of chromosomal copy number alterations.
Size and profile of skyrmions in skyrmion crystals
Authors: Wu Haitao , Hu Xuchong , Jing Keyu , Wang X. R. 
Published: September 2021

AbstractSize is a fundamental quantity of magnetic skyrmions. A magnetic skyrmion can be a local circular object and in an isolated form. A skyrmion can also coexist with a group of its siblings in a condensed phase. Each skyrmion in a condensed phase takes a stripe shape at low skyrmion density and a circular shape at high skyrmion density. Skyrmions at high density form a skyrmion crystal (SkX). So far, skyrmion size in an SkX has not been seriously studied. Here, by using a generic chiral magnetic film, it is found that skyrmion size in an SkX has a different parameter dependence as those for isolated skyrmions and stripes. A size formula and a good spin profile for skyrmions in SkXs are proposed. These findings have important implications in searching for stable smaller skyrmions at the room temperature.
Modelling and analysis of half‐/full‐bridge hybrid MMC when riding through DC‐side pole‐to‐ground fault
Authors: He Zhen , Hu Jiabing , Lin Lei , Zeng Pingliang 
Published: September 2021

AbstractIn a modular multilevel converter‐based high‐voltage direct current (MMC‐HVDC) system, the dc fault ride through (FRT) control is an effective way to deal with a dc‐side pole‐to‐ground (PTG) fault. However, the setting of FRT duration brings potential hazards: 1) MMC will face the risk of “secondary short circuit” if FRT duration is short; 2) ac grid may have power angle stability issue if FRT duration is long. To avoid these hazards and provide theoretical guidance for the FRT duration setting, transient behaviour of dc fault current during the PTG FRT stage is explored in this work. Firstly, challenges of the transient analysis are summarised as non‐linearity and high‐order issues. In light of this, numerical and Hilbert‐Huang Transformation methods are introduced to evaluate the non‐linearity issue. It is found that the path of MMC from dc current to dc internal voltage is weakly non‐linear. Hence, a linear transient model is built to analyse the dc fault current. By participation factor analysis, the order of the proposed model is further reduced, so that an analytical expression of the dc fault current is approximately derived. Based on the analytical expression, regularities and mechanism of dc fault current are fully revealed. Application of the transient analysis to the setting of FRT duration is elaborated in detail. Finally, the PSCAD/EMTDC simulation verifies the validity of the proposed model and analytical expression.
LMI‐based passivation of LTI systems with application to marine structures
Authors: Faedo Nicolás , Peña‐Sanchez Yerai , Carapellese Fabio , Mattiazzo Giuliana , Ringwood John V. 
Published: September 2021

AbstractDue to the inherent relevance of passive (physically representative) models for control, state‐estimation, and motion simulation in the field of marine systems, in this paper, an optimisation‐based approach to passivation of linear time‐invariant (LTI) systems is proposed with application to physically consistent dynamical modelling of marine structures. In particular, the presented strategy is based upon the introduction of a suitably designed perturbation, computed via minimisation of a linear objective subject to a specific set of linear matrix inequalities (LMIs). The performance of the passivation technique is showcased in terms of two case studies: An offshore platform, with a frequency‐domain response computed by means of hydrodynamic codes, and a 1:20 scale wave energy converter (WEC), is characterised in terms of real experimental data.
An embedded discontinuous Galerkin method for the Oseen equations
Authors: Han Yongbin , Hou Yanren 
Published: September 2021

In this paper, thea priorierror estimates of an embedded discontinuous Galerkin method for the Oseen equations are presented. It is proved that the velocity error in theL2(Ω) norm, has an optimal error bound with convergence orderk + 1, where the constants are dependent on the Reynolds number (orν−1), in the diffusion-dominated regime, and in the convection-dominated regime, it has a Reynolds-robust error bound with quasi-optimal convergence orderk + 1/2. Here,kis the polynomial order of the velocity space. In addition, we also prove an optimal error estimate for the pressure. Finally, we carry out some numerical experiments to corroborate our analytical results.
Percutaneous CT Guided Vertebral Biopsy: Anatomy and Technical Considerations
Authors: Gala Kunal Bharat , Shetty Nitin S. , Janu Amit Kumar , Shetty Neeraj , Kulkarni Suyash S. 
Published: September 2021

AbstractIn this review article, the authors discuss the anatomy and technical aspects of CT-guided biopsy of vertebral lesions. CT guidance is highly useful for vertebral biopsies, as the anatomy of the spine is complex and varies widely across the levels. Prebiopsy imaging should be reviewed and later correlated with the final histopathological diagnosis. The majority of the spine biopsies are performed under local anesthesia, except those in critical locations and pediatric age groups. The biopsy sample is sent for histopathological analysis and/or microbiological analysis depending on the indications. It is preferable to use a coaxial system for biopsies, so multiple cores can be obtained with a single needle puncture, thus minimizing the negative yield and complications. Complications after image-guided percutaneous biopsy are rare and can be managed easily.
N-Butyl Cyanoacrylate Embolization in Management of Iatrogenic Renal Hemorrhages—Single-Center Study Evaluating Safety and Efficacy
Authors: Narkhede Amey , Yadav Ajit Kumar , Gupta Arun 
Published: September 2021

Abstract
Objectives The aim of the study was to evaluate the efficacy of endovascular N-butyl cyanoacrylate (NBCA)/glue embolization alone in the management of iatrogenic renal injuries and its effect on renal function.
Methods Thirty-one patients who presented with significant iatrogenic renal injuries over a time period ranging from June 2013 to June 2018 were evaluated. The clinical features, lab parameters, and imaging findings were recorded. The embolizing agent used was exclusively NBCA. The success rate was calculated along with the effect of glue embolization on kidney in the form of postembolization ischemia and change in the serum creatinine levels in immediate pre- and postembolization period. The time between the iatrogenic injury and angioembolization as well as the time from angioembolization to discharge was also calculated. Recurrence was evaluated at 1 and 6 months follow-up.
Results NBCA embolization showed 100% technical and clinical success in our study and no recurrence was noted at follow-up. Glue was also able to achieve complete embolization in patients with coagulopathy (n = 14, 45.1%). Percentage area deficit of normal renal blush in the postembolization check angiogram varied from 4 to 15.7% with a mean deficit of 7.65%. No significant difference in the serum creatinine was noted in immediate postembolization period.
Conclusions We conclude that glue is an effective embolizing agent for management of iatrogenic renal injuries even in coagulopathy patients with minimal area of parenchymal loss, no significant effect on renal functions, and no recurrence on 6 months follow-up.
Optimizing Fluid Resuscitation and Preventing Fluid Overload in Patients with Septic Shock
Authors: Ravi Chandni , Johnson Daniel W. 
Published: September 2021

AbstractIntravenous fluid administration remains an important component in the care of patients with septic shock. A common error in the treatment of septic shock is the use of excessive fluid in an effort to overcome both hypovolemia and vasoplegia. While fluids are necessary to help correct the intravascular depletion, vasopressors should be concomitantly administered to address vasoplegia. Excessive fluid administration is associated with worse outcomes in septic shock, so great care should be taken when deciding how much fluid to give these vulnerable patients. Simple or strict “recipes” which mandate an exact amount of fluid to administer, even when weight based, are not associated with better outcomes and therefore should be avoided. Determining the correct amount of fluid requires the clinician to repeatedly assess and consider multiple variables, including the fluid deficit, organ dysfunction, tolerance of additional fluid, and overall trajectory of the shock state. Dynamic indices, often involving the interaction between the cardiovascular and respiratory systems, appear to be superior to traditional static indices such as central venous pressure for assessing fluid responsiveness. Point-of-care ultrasound offers the bedside clinician a multitude of applications which are useful in determining fluid administration in septic shock. In summary, prevention of fluid overload in septic shock patients is extremely important, and requires the careful attention of the entire critical care team.
Clinical Spectrum of TGM6-Related Movement Disorders: A New Report with a Pooled Analysis of 48 Patients
Authors: Sharawat Indar Kumar , Panda Prateek Kumar , Bhunia Niladri Sekhar , Dawman Lesa 
Published: September 2021

Abstract

Background Spinocerebellar ataxias (SCAs) are a diverse group of progressive neurodegenerative disorders. Until now, more than 20 genes have been implicated to be associated with this phenotype and TGM6 is one of these genes, associated with spinocerebellar ataxia-35 (SCA-35). The majority of disease-causing variants in the TGM6 gene predominantly have been reported from China and Taiwan and the association with Parkinson's disease (PD) have also been reported recently.

Methods We report the first Indian case with SCA-35 in a 16-year-old-boy with atypical age of onset at 9 years, prominent extrapyramidal features, intellectual disability, and a novel missense mutation in the TGM6 gene. We also reviewed and collated all previously published cases with pathogenic TGM6 variants.

Results Including the index case, 54 cases were identified from 10 relevant articles in literature and 48 cases had adequate clinical details to be included in the pooled analysis. Around two-thirds of reported cases had SCA-35 phenotype, with cerebellar atrophy. Onset in the majority of cases was the fourth decade of life onwards. A proportion of SCA-35 cases also had spasmodic torticollis, impaired proprioception, extrapyramidal features, and myoclonic jerks. The patients with PD had often early-onset milder symptoms, slower progression, and favorable response to levodopa/carbidopa. One patient each presented with episodic ataxia and dystonic tremor of the upper limb. Most of the cases had missense mutations, without any definite hotspot or genotype–phenotype correlation.

Conclusions TGM6 mutation should be suspected in patients with SCA like presentation, especially when it is accompanied by extrapyramidal features, spasmodic torticollis, impaired proprioception, or myoclonus.
The Triad of Cognition, Language, and Communication in Traumatic Brain Injury: A Correlational Study
Authors: Darshini Jeevendra Kumar , Afsar Mohammed , Vandana Valiyaparambath Purushothaman , Shukla Dhaval , Rajeswaran Jamuna 
Published: September 2021

Abstract

Objectives Traumatic brain injury (TBI) is associated with deficits in cognition, language, and communication along with physical and psychosocial consequences. This study aimed at evaluating the association between cognition, language, and communication in a cohort of patients with TBI in southern India using standardized language specific assessment tools.

Materials and Methods The present correlational study included 30 patients with TBI of any severity, that is, mild, moderate, and severe within the postinjury period of 6 to 36 months. Comprehensive evaluation of cognition, language, and communication was done using National Institute of Mental Health and Neurosciences Neuropsychology Battery, Indian adapted versions of Western Aphasia Battery and La Trobe Communication Questionnaire (LCQ) respectively.

Data Analysis Measures of descriptive statistics, that is, mean, median, percentages, and frequencies, were used. Raw scores, that is, aphasia quotient (AQ), and subdomain scores for LCQ, that is, LCQ-quality, quantity, relation, manner, and cognition, were calculated. Composite scores for the three neuropsychological domains, that is, attention and processing speed, executive function, learning and memory, were evaluated. Partial correlation was computed for identifying the association between the three variables by controlling for age, education, duration, and severity of injury.

Results A significant correlation was found between AQ and measures of attention and executive functioning and all measures of LCQ except LCQ-manner. Further, a significant correlation was found between executive functioning and LCQ-total, LCQ-quantity, and LCQ cognition. No correlation was found between measures of attention and memory with communication.

Conclusion A good language and executive functioning are associated with better communication abilities in patients with TBI thus emphasizing on the importance of a multidisciplinary team for the management of cognitive-communication impairments following a TBI.
Estimating Bleeding Risk in Patients with Cancer-Associated Thrombosis: Evaluation of Existing Risk Scores and Development of a New Risk Score
Authors: de Winter Maria A. , Dorresteijn Jannick A. N. , Ageno Walter , Ay Cihan , Beyer-Westendorf Jan , Coppens Michiel , Klok Frederikus A. , Moustafa Farès , Riva Nicoletta , Ruiz Artacho Pedro C. , Vanassche Thomas , Nijkeuter Mathilde 
Published: September 2021

Abstract
Background Bleeding risk is highly relevant for treatment decisions in cancer-associated thrombosis (CAT). Several risk scores exist, but have never been validated in patients with CAT and are not recommended for practice.
Objectives To compare methods of estimating clinically relevant (major and clinically relevant nonmajor) bleeding risk in patients with CAT: (1) existing risk scores for bleeding in venous thromboembolism, (2) pragmatic classification based on cancer type, and (3) new prediction model.
Methods In a posthoc analysis of the Hokusai VTE Cancer study, a randomized trial comparing edoxaban with dalteparin for treatment of CAT, seven bleeding risk scores were externally validated (ACCP-VTE, HAS-BLED, Hokusai, Kuijer, Martinez, RIETE, and VTE-BLEED). The predictive performance of these scores was compared with a pragmatic classification based on cancer type (gastrointestinal; genitourinary; other) and a newly derived competing risk-adjusted prediction model based on clinical predictors for clinically relevant bleeding within 6 months after CAT diagnosis with nonbleeding-related mortality as the competing event (“CAT-BLEED”).
Results Data of 1,046 patients (149 events) were analyzed. Predictive performance of existing risk scores was poor to moderate (C-statistics: 0.50–0.57; poor calibration). Internal validation of the pragmatic classification and “CAT-BLEED” showed moderate performance (respective C-statistics: 0.61; 95% confidence interval [CI]: 0.56–0.66, and 0.63; 95% CI 0.58–0.68; good calibration).
Conclusion Existing risk scores for bleeding perform poorly after CAT. Pragmatic classification based on cancer type provides marginally better estimates of clinically relevant bleeding risk. Further improvement may be achieved with “CAT-BLEED,” but this requires external validation in practice-based settings and with other DOACs and its clinical usefulness is yet to be demonstrated.
Selective Hemorrhoidal Dearterialization with High Mucopexy in the Surgical Treatment of Hemorrhoidal Disease
Authors: Rotta Carlos Mateus , Drago Stephanie , Sousa Afonso Henrique da Silva e , Martinez Carlos Augusto Real , Bernardino Marjorie Cristina da Cruz 
Published: September 2021

AbstractThe doppler-guided transanal hemorrhoidal dearterialization technique associated with mucopexy is a noninvasive surgical option used to treat hemorrhoidal disease (HD).
Objective To compare and analyze the results using a variation of the doppler-guided transanal hemorrhoidal dearterialization technique with the technique of selective hemorrhoidal dearterialization with high mucopexy in the treatment of HD.
Method A total of 292 patients who underwent surgical treatment for grade II, III and IV HD from March 2012 to December 2017 were studied. From this total, 110 (37.6%) patients underwent a conventional doppler-guided transanal hemorrhoidal dearterialization with mucopexy (CD), and 182 (62.3%) underwent selective hemorrhoidal dearterialization with high mucopexy (SHeLF). In the group of patients undergoing CD, 4 patients (3.64%) had grade II HD, 82 (74.55%) grade III, and 24 (21.82%) grade IV. In the group submitted to SHeLF, 18 (9.89%) patients had grade II HD, 86 (47.25%) had grade III, and 65 (35.71%) had grade IV. The same surgeon operated all patients under spinal anesthesia. In patients undergoing CD, six arterial branches have been dearterialized, while in patients undergoing SHeLF, the hemorrhoidary nipples submitted to a dearterialization were selected (from 1 to 5) by intraoperative evaluation followed by high rectal mucopexy. In the postoperative period, the following parameters were evaluated: pain, tenesmus, bleeding, and recurrence.Moderate results to severe pain was a postoperative complaint reported by 13 (11.82%) patients undergoing CD, and by 19 (10.44%) undergoing SHeLF. Intense tenesmus was reported by 26 (23.64%) patients undergoing CD and by 7 (3.85%) undergoing SHeLF. Three patients (2.73%) undergoing CD and 1 (0.55%) undergoing SHeLF evolved with postoperative bleeding. One patient (0.55%) in the group undergoing CD required surgical review of hemostasis. Six patients (5.45%) who underwent CD and 8 (4.39%) who underwent SHeLF were reoperated due to disease recurrence.
Conclusion Comparing statistics, patients undergoing the SHeLF technique have less postoperative pain, tenesmus and postoperative bleeding when compared with CD.