bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perancangan Animasi tentang Sosialisasi Kembali Bersekolah bagi Anak di Pasca Pandemi menggunakan Teknik Motion Graphic
Authors: Kadiasti Ristia , Mukaromah Mukaromah 
Published: October 2021

AbstrakDampak yang dirasakan akibat pandemi Covid-19 berpengaruh tidak hanya pada kondisi ekonomi namun juga psikologis khususnya pada anak-anak. Hal tersebut terlihat pada perkembangan proses belajar anak pada saat kegiatan belajar mengajar melalui media daring, seperti kesulitan berkonsentrasi, gelisah, dan rasa khawatir yang berlebihan. Kebutuhan untuk memotivasi anak-anak dalam menyerap pelajaran kembali menjadi sebuah hal yang mendesak ketika mereka akan kembali bersekolah secara tatap muka pasca pandemi nanti. Namun, sebelum menempatkan anak-anak ke dalam kondisi tersebut, perlu adanya sebuah program yang membekali anak-anak sebelum kegiatan berbasis kurikulum dilaksanakan. Penelitian ini menggunakan pengumpulan data dari penelitian program intervensi kembali bersekolah oleh Jhoni Warmansyah dan menggunakan metode perancangan dengan model SMCR (Source, Message, Channel, Receiver) yang kemudian menghasilkan media video infografis berbentuk motion graphic berupa sosialisasi dengan konten pesan membekali anak dalam mematuhi protokol kesehatan ketika kembali bersekolah. Animasi ini memberikan edukasi terkait pengenalan emosi anak pada masa pandemi dan juga memberikan pembekalan berupa demonstrasi tentang pematuhan protokol kesehatan pada anak-anak di saat mereka kembali bersekolah nanti. Kata Kunci: anak, animasi, motion graphic, pandemi, sosialisasi AbstractThe impact perceived due to the Covid-19 pandemic affects economic conditions and also psychologically, especially on children. This indication can be seen in the development of children's learning processes during teaching and learning activities through online media. Children sometimes feel difficulty concentrating, anxiety, and excessive worry. The need to motivate children to absorb lessons again becomes an urgent matter when they return to school face to face after the pandemic. However, before placing children into this condition, it is necessary to have a program that equips children before implementing the activities. This study uses data collected from the back-to-school intervention program research by Jhoni Warmansyah along with the SMCR model that later can produce infographic video media in the form of motion graphics. This animation provides education regarding the introduction of children's emotions during the pandemic and further provides instruction in the form of demonstrations on compliance with health protocols for children when they return to school later. Keywords: child, animation, campaign, motion graphic, pandemic
Perancangan Film Pendek “Simbah” sebagai Media Pembelajaran pada Mata Kuliah Audio Visual
Authors: Nugraini Siti Hadiati 
Published: October 2021

AbstrakPenelitian ini membahas tentang perancangan film pendek dengan judul “Simbah” sebagai salah satu media yang dapat digunakan sebagai media pembelajaran mata kuliah Audio Visual pada mahasiswa semester 5. Film ini dibuat sebagai media untuk memberikan pendidikan moral kepada mahasiswa. Film ‘Simbah’ berisi nilai-nilai moral untuk orang dewasa yang sangat penting untuk dikenalkan pada mahasiswa. Salah satu aspek dari nilai-nilai moral dalam film tersebut adalah keinginan yang perlu dikendalikan. Keinginan merupakan salah satu sifat dasar yang dimiliki manusia dan harus dikendalikan sejak usia muda. Salah satu strategi yang dapat digunakan pendidik untuk menanamkan nilai tersebut adalah dengan media audio visual berupa film pendek. Metode yang digunakan dalam penelitian ini adalah metode kualitatif karena dapat mengungkapkan aspek-aspek yang harus ditekankan dalam sebuah film pendek, sehingga penanaman nilai bahwa keinginan perlu dikendalikan dapat dilakukan. Sebagai hasilnya film pendek ‘Simbah’ menjadi salah satu media pembelajaran yang menarik dan dapat mengarahkan serta membuat mahasiswa mengerti dengan latar belakang budaya. Selain itu sinematografi film ‘Simbah’ memudahkan mahasiswa untuk memahami alur cerita dan menjadi referensi dalam perancangan mata kuliah audio visual. Kata Kunci: audio visual, film pendek, media pembelajaran, simbah AbstractThis research discusses the design of a short movie with the title "Simbah" as one of the media that uses as a learning medium for studying Audio Visual courses for 5th-semester students. This short movie was made as a medium to provide moral education for students. 'Simbah' contains moral values for adults that are very important to introduce to students. One aspect of the moral values in the movie is the desire that needs to control. Desire is one of the primary human traits and must restrain from a young age. One strategy that educators can use to instill these values is with audio-visual media in the form of short movie. The method used in this study is qualitative because it can reveal aspects that must be emphasized in a short film so that the inculcation of the value that desires need to control can be carried out. As a result, the short movie 'Simbah' became one of the interesting learning media and could direct students to understand the cultural background. In addition, the cinematography of the 'Simbah' movie makes it easier for students to understand the storyline and becomes a reference in making short films in audio visual courses. Keywords: audio visual, learning media, short movie, simbah
Correlation Between Quantitative Uptake of 99mTC-DPD and Echocardiographic Parameters in Cardiac ATTR: A Novel Follow-Up Strategy
Authors: Harapoz Mehmet , Evans Scott , Geenty Paul , Kwok Fiona , Stewart Graeme , Taylor Mark S. , Farlow David , Thomas Liza 
Published: October 2021

Aims: There has been a paradigm shift in diagnosis of cardiac transthyretin amyloidosis (ATTR) with non-invasive techniques including technetium-99m 3,3-diphosphono-1,2-propanodicarboxylic acid (99mTc-DPD) bone scintigraphy. We evaluated structural and functional biventricular alterations by transthoracic echocardiography (TTE) and determined the correlation with 99mTc-DPD tracer uptake in ATTR.Materials and Methods: ATTR patients (wild-type, hereditary or asymptomatic transthyretin [TTR] variant carriers) with 99mTc-DPD and TTE were selected; 99mTc-DPD uptake was analyzed quantitatively. TTE assessment of left ventricle (LV) and right ventricle (RV) parameters was performed.Results: Forty ATTR patients (wild-type n = 17; hereditary ATTR and TTR variant carriers n = 23; median age 68.8 ± 22 years) were included. TTE parameters displaying good correlation with 99mTc-DPD tracer uptake included LV average wall thickness (r = 0.837), LV indexed mass (LVMI; r = 0.802), RV wall thickness (r = 0.610), average e' (r = −0.830), E/e' ratio (r = 0.786), LV global longitudinal strain (GLS; r = 0.714) and RV GLS (r = 0.632; p &lt; 0.001 for all). Hereditary ATTR and TTR variant carriers without cardiac tracer uptake had normal echocardiographic parameters. Receiver operating characteristic curves demonstrated strong diagnostic accuracies for structural (LV wall thickness, LVMI and RV wall thickness; area under the curve (AUC) of 0.96 for all) and functional (LV and RV GLS; AUC of 0.86 and 0.88, respectively) parameters.Conclusion: Good correlations between TTE biventricular structural and functional parameters were demonstrated with quantitative 99mTc-DPD uptake. Echocardiography may potentially assume a significant role in longitudinal follow-up for monitoring disease progression and for evaluating treatment response.
Patients With Microscopic Colitis Have Altered Levels of Inhibitory and Stimulatory Biomarkers in Colon Biopsies and Sera Compared to Non-inflamed Controls
Authors: Lushnikova Alexandra , Bohr Johan , Wickbom Anna , Münch Andreas , Sjöberg Klas , Hultgren Olof , Wirén Anders , Hultgren Hörnquist Elisabeth 
Published: October 2021

Introduction: Microscopic colitis (MC) is an inflammatory bowel condition with two subtypes, lymphocytic colitis (LC) and collagenous colitis (CC). Unlike patients with ulcerative colitis (UC) and non-inflamed individuals, MC patients have reduced risk of developing colorectal cancer, possibly due to increased immune surveillance in MC patients.Aim: To examine differences in levels of immunomodulatory molecules, including those involved in immune checkpoint mechanisms, in sera from patients with MC and in colonic biopsies from patients with MC and UC compared with controls.Methods: Using Luminex, 23 analytes (4-1BB, 4-1BBL, APRIL, BAFF, BTLA, CD27, CD28, CD80, CTLA-4, E-cadherin, Galectin-3, GITR, HVEM, IDO, IL-2Rα, LAG-3, MICA, MICB, PD-1, PD-L1, PD-L2, sCD40L and TIM-3) were studied in serum from patients with active MC (n = 35) and controls (n = 23), and in colonic biopsies from patients with active LC (n = 9), active CC (n = 16) and MC in histological remission (LC n = 6, CC n = 6), active UC (n = 15) and UC in remission (n = 12) and controls (n = 58).Results: In serum, IDO, PD-1, TIM-3, 4-1BB, CD27, and CD80 were decreased whereas 4-1BBL and IL-2Rα were increased in MC patients compared with controls. In contrast, in biopsies, levels of PD-L2 and 4-1BB were increased in MC and UC patients with active disease. Furthermore, in biopsies from CC and UC but not LC patients with active disease, CTLA-4, PD-1, APRIL, BAFF, and IL-2Rα were increased compared with controls. PD-L1 was increased in CC but not UC or LC patients. CD27 and TIM-3 were decreased in biopsies from MC patients in comparison to controls whereas levels of MICB were decreased in patients with active UC compared with controls.Conclusions: Compared with non-inflamed controls, levels of soluble and membrane-bound immunomodulatory molecules were systemically and locally altered in MC and UC patients, with most analytes being decreased in serum but enhanced in colonic biopsies. These findings contribute to knowledge about checkpoint molecules and their role as biomarkers in MC and may also contribute to knowledge about possible mechanisms behind the seemingly protective effects of MC against colorectal cancer.
Lung Cancer Death Attributable to Long-Term Ambient Particulate Matter (PM2.5) Exposure in East Asian Countries During 1990–2019
Authors: Liu Xiaoxue , Mubarik Sumaira , Wang Fang , Yu Yong , Wang Yafeng , Shi Fang , Wen Haoyu , Yu Chuanhua 
Published: October 2021

Background: Ambient particulate matter is a public health concern in East Asia as it contributes to a growing number of all-cause and cancer deaths. This study aimed to estimate lung cancer death attributable to ambient particulate matter (PM) &lt; 2.5 μm (PM2.5) in East Asia countries.Methods: The attributable death rates of lung cancer were estimated based on the calculation of population attributable fraction. We performed joinpoint regression analysis and age-period-cohort (APC) model to estimate temporal trends of the attributable death to PM2.5.Results: In 2019, PM2.5 was estimated to have caused 42.2% (nearly 0.13 million) of lung cancer deaths in East Asia men. During 1990–2019, the increase in age-standardized death rates of lung cancer attributable to PM2.5 was highest in China, which increased by 3.50% in males and 3.71% in females. The death rate caused by PM2.5 also significantly increased in the Democratic People's Republic of Korea (2.16% in males; 3.06% in females). Joinpoint analysis showed that the rates generally increased in younger and older people in both the Democratic People's Republic of Korea and Mongolia, while it only increased in elderly people in other countries'. Age effect from APC analysis demonstrated the risk of lung cancer death attributable to PM2.5 generally increased from young to old age. Period effect indicated that from 1994–1998 to 2019–2023 period risk continuously increased by 1.77, 1.68, and 1.72 times in China, the Democratic People's Republic of Korea, and Japan, respectively. The period risk decreased from 1999 to 2009 and subsequently increased from 2009 to 2019 in both the Republic of Korea and Mongolia.Conclusions: The death rate of lung cancer attributable to PM2.5 is increasing in the Democratic People's Republic of Korea, Mongolia, and China. In East Asia, China is facing the highest attributable death rate in recent decades. The period effect suggested a remarkably increased risk of lung cancer death caused by PM2.5 in China, the Democratic People's Republic of Korea, and Japan during the long-term period. It is recommended that the governments of these countries should continuously concentrate on particulate matter pollution governance and improvement.
Associations Between the Density of Oil and Gas Infrastructure and the Incidence, Stage and Outcomes of Solid Tumours: A Population-Based Geographic Analysis
Authors: Jost Evan , Dingley Brittany , Jost Casey , Cheung Winson Y. , Quan May Lynn , Bouchard-Fortier Antoine , Kong Shiying , Xu Yuan 
Published: October 2021

BackgroundWe hypothesized that there are geographic areas of increased cancer incidence in Alberta, and that these are associated with high densities of oil and gas(O+G) infrastructure. Our objective was to describe the relationship between O+G infrastructure and incidence of solid tumours on a population level.MethodsWe analyzed all patients &gt;=18 years old with urological, breast, upper GI, colorectal, head and neck, hepatobiliary, lung, melanoma, and prostate cancers identified from the Alberta Cancer Registry from 2004-2016. Locations of active and orphan O+G sites were obtained from the Alberta Energy Regulator and Orphan Well Association. Orphan sites have no entity responsible for their maintenance. ArcGIS (ESRI, Toronto, Ontario) was used to calculate the distribution of O+G sites in each census distribution area (DA). Patient residence at diagnosis was defined by postal code. Incidence of cancer per DA was calculated and standardized. Negative binomial regression was done on O+G site density as a categorical variable with cutoffs of 1 and 30 wells/100km2, compared to areas with 0 sites.Results125,316 patients were identified in the study timeframe;58,243 (46.5%) were female, mean age 65.6 years. Breast (22%) and prostate (19.8%) cancers were most common. Mortality was 36.5% after a median of 30 months follow up (IQR 8.4 – 68.4). For categorical density of active O+G sites, RR was 1.02 for 1-30 sites/100km2 (95% CI=0.95-1.11) and 1.15 for &gt;30 sites/100km2 (p&lt;0.0001, 95%CI=1.11-1.2). For orphan sites, 1-30 sites RR was 1.25 (p&lt;0.0001, 95%CI=1.16-1.36) and 1.01 (p=0.97, 95%CI=0.7-1.45) for &gt;30 sites. For all O+G sites, RR for 1-30 sites was 1.03 (p=0.4328, 95%CI=0.95-1.11) and 1.15 (p&lt;0.0001, 95%CI=1.11-1.2) for &gt;30 sites.ConclusionWe report a statistically significant correlation between O+G infrastructure density and solid tumour incidence in Alberta. To our knowledge this is the first population-level study to observe that active and orphan O+G sites are associated with increased risk of solid tumours. This finding may inform policy on remediation and cancer prevention.
Case Report: Factor VII Deficiency Presented With Cephalohematoma After Birth
Authors: Lo Yuan-Chun , Peng Ching-Tien , Chen Yin-Ting 
Published: October 2021

Introduction: Factor VII deficiency is a rare inherited autosomal recessive bleeding disorder with a global prevalence of 1/500,000. Most cases remain asymptomatic, and cases with severe clinical presentation are rarely reported.Case Presentation: A newborn male with no relevant maternal antenatal history, delivered via vacuum-assisted cesarean section, presented with a large cephalohematoma after delivery. Poor appetite, pale appearance, and bulging fontanelles were observed 2 days later, progressing to hypovolemic shock. Further imaging examination revealed a large intracranial hemorrhage. Serial laboratory examination revealed remarkable coagulopathy with prolonged prothrombin time and factor VII deficiency (&lt;1%, severe type). The patient was genetically confirmed to have the FVII:c 681+1 G&gt;T homozygous mutation. Brain hemorrhage was resolved with high-dose factor VII replacement therapy with recombinant activated factor VII. However, repeated hemothorax and intracranial hemorrhage were detected. Therefore, the patient was under regular factor VII supplementation with a rehabilitation program for cerebral palsy.Conclusions: A case of factor VII deficiency with large cephalohematoma and intracranial hemorrhage after birth is described herein, which was treated with high-dose replacement therapy. Variants of the FVII:c 681+1 G&gt;T (IVS6+1G&gt;T) homozygous genotype may present with a severe phenotype at the neonatal stage. We aim to share a unique neonatal presentation with a certain genotype and treatment experience with initial replacement therapy, followed by regular prophylactic dosage.
Influence of Cytochrome P450 2C19 Genotype on Helicobacter pylori Proton Pump Inhibitor-Amoxicillin-Clarithromycin Eradication Therapy: A Meta-Analysis
Authors: Morino Yuko , Sugimoto Mitsushige , Nagata Naoyoshi , Niikiura Ryota , Iwata Eri , Hamada Mariko , Kawai Yusuke , Fujimiya Tatsuhiro , Takeuchi Hironori , Unezaki Sakae , Kawai Takashi 
Published: October 2021

Background: Proton pump inhibitors (PPIs) are the first-line treatment for acid-related diseases. The pharmacokinetics and therapeutic efficacy of PPIs, however, are influenced by genetic factors such as variants in genes encoding drug-metabolizing enzymes (e.g., cytochrome P450 2C19 [CYP2C19]) and drug transporters. We performed a meta-analysis to evaluate the influence of CYP2C19 genotype and PPI class, PPI dose, treatment duration and clarithromycin dose on the cure rate of PPI-containing Helicobacter pylori eradication therapy.Methods: Randomized control trials (RCTs) investigating cure rates using a PPI-amoxicillin-clarithromycin regimen among different CYP2C19 genotypes through May 2021 were included.Results: A total of 25 studies (5,318 patients) were included. The overall eradication rate in the intention-to-treat analysis was 79.0% (3,689/4,669, 95% confidence interval [CI]: 77.8–80.2%), and that in CYP2C19 extensive metabolizers (EMs), intermediate metabolizer (IMs) and poor metabolizers (PMs) was 77.7% (1,137/1,464, 95% CI: 75.3–79.6%), 81.2% (1,498/1,844, 95% CI: 79.3–83.0%) and 86.8% (644/742, 95% CI: 83.9–88.9%), respectively. Meta-analysis showed that the relaTakashitive risk of failed eradication in CYP2C19 EMs compared with IMs and PMs was 1.21 (95% CI: 1.06–1.39, P = 0.006) and 1.57 (95% CI: 1.27–1.94, P &lt; 0.001), respectively, in the fixed-effects model. The cure rate of omeprazole and lansoprazole-containing eradication regimens differed among CYP2C19 genotypes (P &lt; 0.05), while that of rabeprazole and esomeprazole-containing regimens was similar.Conclusion: The cure rates of PPI-amoxicillin-clarithromycin H. pylori eradication regimen, especially those containing omeprazole and lansoprazole, differ among CYP2C19 genotypes. Therefore, selection of a second-generation PPI or tailored treatment may achieve higher eradication rates than first-generation PPI-amoxicillin-clarithromycin triple regimen.
Emotion Reactivity and Suicide Risk in Patients With Depression: The Mediating Role of Non-Suicidal Self-Injury and Moderating Role of Childhood Neglect
Authors: Wang Lu , Cui Qian , Liu Jun , Zou Haiou 
Published: October 2021

Background: The association between emotion reactivity (ER) and suicide risk has been confirmed in recent studies, especially in patients with depression. However, there is a lack of understanding of the underlying mechanism of the relation from ER to suicide risk among patients with depression. This study planned to examine a model of how ER, non-suicidal self-injury (NSSI), and childhood neglect (CN) interact to affect suicide risk in depressed patients.Methods: Four hundred and ninety-six patients (64.5% female, mean age = 30.40 years, SD = 12.56) who have accomplished self-rating instruments of ER, NSSI, CN, and suicide risk were included.Results: Findings showed that ER was positively connected with suicide risk, and NSSI partially mediated the above connection. Besides, CN moderated the mediation model, that is, the mediation effect was more pronounced in depressed patients with CN compared to depressed patients without CN.Conclusions: It was concluded that there is a relationship among ER, NSSI, CN, and suicide risk in patients with depression, and it strengthens our knowledge of the mechanism behind suicide risk. Our findings emphasize that the identification of NSSI and CN should be considered when assessing the suicide risk of patients with depression, as well as the intervention focus on emotion regulation and support for patients.
Imagen de la Licenciatura en Administración (UNR) en aquellos estudiantes de Ciencias Económicas que no la eligieron
Authors: Oviedo Raúl Ricardo , Racca Adriana Patricia , Suñer María Natalia , Fior Marina , Ford Jairo Jesús 
Published: October 2021

El presente artículo aborda la imagen que tienen de la Licenciatura en Administración los alumnos de las demás carreras de Ciencias Económicas, en torno a su perfil profesional, competencias específicas, ámbito de desarrollo profesional entre otras cuestiones.
Luego de realizar un relevamiento de corte cuantitativo se obtuvo como resultado que, con sus matices, tanto los estudiantes de Contador Público como de Licenciatura en Economía coinciden en la mayoría de sus respuestas en lo que respecta a la representación de la Licenciatura en Administración.