bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review to examine the relationship between objective and patient‐reported outcome measures in sinonasal disorders: recommendations for use in research and clinical practice
Authors: Ta Ngan Hong , Gao Jack , Philpott Carl 
Published: January 2021

BackgroundCommon sinonasal disorders include chronic rhinosinusitis (CRS), allergic rhinitis (AR), and a deviated nasal septum (DNS), which often coexist with shared common symptoms including nasal obstruction, olfactory dysfunction, and rhinorrhea. Various objective outcome measures and patient‐reported outcome measures (PROMs) are used to assess disease severity; however, there is limited evidence in the literature on the correlation between them. This systematic review aims to examine the relationship between them and provide recommendations.MethodsA search of MEDLINE and EMBASE identified studies quantifying correlations between objective outcome measures and PROMs for the sinonasal conditions using a narrative synthesis.ResultsIn total, 59 studies met inclusion criteria. For nasal obstruction, rhinomanometry shows a lack of correlation whereas peak nasal inspiratory flow (PNIF) shows the strongest correlation with PROMs (r > 0.5). The Sniffin’ Stick test shows a stronger correlation with PROMs (r > 0.5) than the University of Pennsylvania Smell Identification Test (UPSIT) (r < 0.5). Computed tomography (CT) sinus scores show little evidence of correlation with PROMs and nasal endoscopic ratings (weak correlation, r < 0.5).ConclusionOverall, objective outcome measures and PROMs assessing sinonasal symptoms are poorly correlated, and we recommend that objective outcome measures be used with validated PROMs depending on the setting. PNIF should be used in routine clinical practice for nasal obstruction; rhinomanometry and acoustic rhinometry may be useful in research. The Sniffin’ Sticks test is recommended for olfactory dysfunction with UPSIT as an alternative. CT scores should be excluded as a routine CRS outcome measure, and endoscopic scores should be used in combination with PROMs until further research is conducted.
Lipid Fractions, Fatty Acid Profiles, and Bioactive Compounds of Lithospermum officinale L. Seeds
Authors: Lyashenko Svetlana , Yunusova Svetlana , López‐Ruiz Rosalía , Vasfilova Evgeniya , Kiseleva Olga , Chimitov Daba , Bahanova Milada , Bojko Natalija , Guil‐Guerrero José Luis 
Published: January 2021

AbstractSeeds of Lithospermum officinale L. from different climatic zones were analyzed for new sources of γ‐linolenic acid (GLA, 18:3n‐6) and stearidonic acid (SDA, 18:4n‐3). Cultured Borago officinalis was also analyzed for comparative purposes. Analyses were conducted for fatty acid (FA) profiles of the glyceride oils from the seeds and in the neutral and polar lipids by gas chromatography (GC); lipid classes by open column chromatography and preparative thin layer chromatography (TLC); and tocopherols, sterols, and phenolic compounds by high‐performance liquid chromatography with diode array detection (HPLC‐DAD), and the later compounds were confirmed by liquid‐chromatography‐mass spectrometry (LC–MS). L. officinale from St. Petersburg Botanical Garden showed the highest percentage of GLA (17.9% of total FA), while wild‐growing L. officinale from the Rostov region contained the highest percentage of SDA (17.2% of total FA). Total FA content ranged from 11.3 to 20.8% of seed weight. Neutral and polar lipids accounted for ~98 and 2.27%, respectively, of total lipids. Five neutral lipid classes were identified (% of NL): triterpene esters (1.3), triacylglycerols (93.1), free FA (1.8), diacylglycerols (1.4), and monoacylglycerols (2.4). The highest tocopherol content was found in samples from Chechen Republic (35.7 mg/100 g), in which the δ isomer was the main component. Samples from the Rostov region had the highest amounts of sterols (83.8 mg/100 g), and Δ5‐avenasterol was the predominant compound in all samples. L. officinale seeds contain high amounts of phenolic compounds (389.9 mg/100 g as upper limit), in which rosmarinic acid is highlighted. Overall, all data suggest the possibility of using L. officinale seed oil in pharmaceutical and cosmetic formulae and as functional food.
What deubiquitinating enzymes, oncogenes, and tumor suppressors actually do: Are current assumptions supported by patient outcomes?
Authors: Gregoire‐Mitha Sophie , Gray Douglas A. 
Published: January 2021

AbstractContext can determine whether a given gene acts as an oncogene or a tumor suppressor. Deubiquitinating enzymes (DUBs) regulate the stability of many components of the pathways dictating cell fate so it would be expected that alterations in the levels or activity of these enzymes may have oncogenic or tumor suppressive consequences. In the current review we survey publications reporting that genes encoding DUBs are oncogenes or tumor suppressors. For many DUBs both claims have been made. For such “double agents,” the effects of gain or loss of function will depend on the overall status of a complex of molecular signaling networks subject to extensive crosstalk. As the TGF‐β paradox makes clear context is critical in cell fate decisions, and the disconnect between experimental findings and patient survival outcomes can in part be attributed to disparities between culture conditions and the microenvironment in vivo. Convincing claims for oncogene or tumor suppressor roles require the documentation of gene alterations in patient samples; survival curves are alone inadequate.
New lanthanide‐free self‐activated full‐color emission phosphor in Y3+ doped Sr3Bi(VO4)3 system for white light emitting diode applications
Authors: Sreena T.S. , Rao P. Prabhakar , Thara T.R. Aju , Raj Athira K.V. 
Published: January 2021

AbstractCommercially used inorganic phosphors heavily depend on lanthanide doped host materials which are becoming more expensive and also their availability is limited due to scarcity. In this regard, a new lanthanide‐free self‐activated full‐color emission phosphor in Y3+ doped Sr3Bi(VO4)3 system was developed by the conventional ceramic route. These phosphors crystallize into a hexagonal‐type palmierite mineral structure. They exhibit broad excitation bands in the wavelength region of 250–400 nm, owing to the charge transfer transitions from both O2− and Bi6s2 electrons to V5+. Upon excitation, these phosphors show bright broad emissions in the 400–750 nm wavelength range, peaking around 535 nm, with a large full width half maximum of 160 nm. The Y substitution allows tuning of the emission from yellowish green to bluish white due to increased distortion of [VO4]3− tetrahedron. Consequently, the CIE color coordinates changed from (0.42, 0.50) to (0.31, 0.35) which lies in the near‐white region in the chromaticity diagram. Thus, the newly developed Y doped Sr3Bi(VO4)3 is a promising lanthanide‐free full‐color emission phosphor for applications in pc‐white light emitting diodes.
Specific situations may require different relative indications
Authors: Zaalouk Tamer Mohamed , Bitar Zouheir Ibrahim , Maadarani Ossama Sajeh 
Published: January 2021

AbstractIn specific situations such as patient with severely dilated left ventricle (LV) and spontaneous echo contrast (SEC) who suffered an ischemic stroke previously may be an acceptable indication for oral anticoagulation to prevent further TE events.
Amination of Cyclohexanol over a Ni‐Based Catalyst – Part II: Catalyst Stability and Reaction Pathway
Authors: Churro Rui , Mendes Fernando , Araújo Paulo , Ribeiro Maria Filipa , Madeira Luís M. 
Published: January 2021

AbstractNi‐based catalysts present a highly interesting performance for the reductive amination of cyclohexanol (CHOL). The stability of a commercial Ni‐based catalyst was evaluated and a high stability over the tested time‐on‐stream (TOS) was observed. The reaction network was evaluated by analysis of selectivity profiles as a function of CHOL conversion. The formation of cyclohexylamine (CHA) was found to be consistent with the proposed borrowing hydrogen method (BHM). The formation of heavy‐end (HE) by‐products also follows the BHM pathway as parallel reaction. The effect of individual molar proportions of NH3 and H2 was evaluated. It was found that when H2 is present in a high excess, side reactions were favored, but its presence is mandatory towards keeping the catalyst active.
PRMT5 promotes progression of endometrioid adenocarcinoma via ERα and cell cycle signaling pathways
Authors: Mei Shuyu , Ge Shuang , Wang Jun , Li Hailing , Jing Xiaotong , Liang Ke , Zhang Xiaoying , Xue Chaoshuai , Zhang Cuijuan , Zhang Tingguo 
Published: January 2021

AbstractProtein arginine methyltransferase 5 (PRMT5) has previously been reported to be upregulated in many malignant tumors. This study investigated the significance of PRMT5 in endometrial carcinoma (EC) and explored its function in tumorigenesis. Immunohistochemistry was performed to evaluate PRMT5 expression in 62 EC and 66 endometrial hyperplasia samples. The functions of PRMT5 were investigated by cell counting kit‐8, plate colony formation, wound healing, and transwell and flow cytometry assays. Quantitative reverse transcription‐polymerase chain reaction and western blotting were used to measure the expression of PRMT5, changes in estrogen receptor α (ERα), and related functional proteins. Coimmunoprecipitation was performed to examine the interaction of PRMT5 with ERα and its coactivator steroid receptor coactivator‐1 (SRC1). Compared to endometrial hyperplasia tissue, PRMT5 was overexpressed in endometrioid adenocarcinoma (EAC) but not overexpressed in mucinous EC. The main expression pattern of PRMT5 in EAC was cytoplasmic. However, the positive cases of endometrial hyperplasia showed both cytoplasmic and nuclear positivity in the endometrial glands or were mainly positive in stromal cells. Knockdown of PRMT5 significantly inhibited the growth and migration ability of EAC cells and promoted their apoptosis by regulating cyclin D1, c‐myc, p53, and Bcl2 proteins. Furthermore, PRMT5 could form a complex with ERα and SRC1 to promote the expression of ERα. In conclusion, PRMT5 plays a significant role in the progression of EAC by interacting with ERα and impacting the cell cycle signaling pathways.
Climate effects on nesting phenology in Nebraska turtles
Authors: Hedrick Ashley R. , Greene Daniel U. , Lewis Erin L. , Hood Andrew S. , Iverson John B. 
Published: January 2021

AbstractA frequent response of organisms to climate change is altering the timing of reproduction, and advancement of reproductive timing has been a common reaction to warming temperatures in temperate regions. We tested whether this pattern applied to two common North American turtle species over the past three decades in Nebraska, USA. The timing of nesting (either first date or average date) of the Common Snapping Turtle (Chelydra serpentina) was negatively correlated with mean December maximum temperatures of the preceding year and mean May minimum and maximum temperatures in the nesting year and positively correlated with precipitation in July of the previous year. Increased temperatures during the late winter and spring likely permit earlier emergence from hibernation, increased metabolic rates and feeding opportunities, and accelerated vitellogenesis, ovulation, and egg shelling, all of which could drive earlier nesting. However, for the Painted Turtle (Chrysemys picta), the timing of nesting was positively correlated with mean minimum temperatures in September, October, December of the previous year, February of the nesting year, and April precipitation. These results suggest warmer fall, and winter temperature may impose an increased metabolic cost to painted turtles that impedes fall vitellogenesis, and April rains may slow the completion of vitellogenesis through decreased basking opportunities. For both species, nest deposition was highly correlated with body size, and larger females nested earlier in the season. Although average annual ambient temperatures have increased over the last four decades of our overall fieldwork at our study site, spring temperatures have not yet increased, and hence, nesting phenology has not advanced at our site for Chelydra. While Chrysemys exhibited a weak trend toward later nesting, this response was likely due to increased recruitment of smaller females into the population due to nest protection and predator control (Procyon lotor) in the early 2000s. Should climate change result in an increase in spring temperatures, nesting phenology would presumably respond accordingly, conditional on body size variation within these populations.
Microglial inflammasome activation drives developmental white matter injury
Authors: Holloway Rebecca K. , Ireland Graeme , Sullivan Gemma , Becher Julie‐Clare , Smith Colin , Boardman James P. , Gressens Pierre , Miron Veronique E. 
Published: January 2021

AbstractInjury to the developing brain during the perinatal period often causes hypomyelination, leading to clinical deficits for which there is an unmet therapeutic need. Dysregulation of inflammation and microglia have been implicated, yet the molecular mechanisms linking these to hypomyelination are unclear. Using human infant cerebrospinal fluid (CSF) and postmortem tissue, we found that microglial activation of the pro‐inflammatory molecular complex the NLRP3 inflammasome is associated with pathology. By developing a novel mouse brain explant model of microglial inflammasome activation, we demonstrate that blocking the inflammasome rescues myelination. In human and mouse, we discovered a link between the inflammasome product IL1β and increased levels of follistatin, an endogenous inhibitor of activin‐A. Follistatin treatment was sufficient to reduce myelination, whereas myelination was rescued in injured explants upon follistatin neutralization or supplementation with exogenous activin‐A. Our data reveal that inflammasome activation in microglia drives hypomyelination and identifies novel therapeutic strategies to reinstate myelination following developmental injury.
Swine manure dilution with lagoon effluent impact on odor reduction and manure digestion
Authors: Hwang Okhwa , Scoggin Kenwood , Andersen Daniel , Ro Kyoung , Trabue Steven 
Published: January 2021

AbstractManure management systems have a major impact on odor from swine operations. A study was conducted to compare deep‐pit manure management systems to flushing barn manure management systems for odor reduction and organic matter degradation. Bioreactors were used to mimic manure management systems in which manure and lagoon effluent were loaded initially, and subsequent manure was added daily at 5% of its storage capacity (1 L). Final manure‐to‐lagoon effluent ratios were 10:0 (deep‐pit manure management system), 7:3 (Korean flushing systems), 5:5 (enhanced flushing systems), and 2:8 (enhanced flushing systems). At the end of the trial, at 4 (2:8), 10 (5:5), or 14 (10:0, 7:3) d, manure and gas concentrations of odorants were measured, including total solids (TS), total N (TN), and total C (TC) of manure. Odor was evaluated using the odor activity values (OAVs), and regression analysis was used to determine the effects of dilution and TS on manure properties and OAVs. Solids in the manure were positively correlated to TN, TC, straight chain fatty acids (SCFAs), branch chain fatty acids (BCFAs), total phenols, and total indoles and positively correlated to OAV for SCFAs, BCFAs, ammonia, total phenols, and total indoles. Reducing TS by 90% reduced BCFA, ammonia, phenols, and indoles by equal amounts in air. Carbon dioxide was the main C source evolved, averaging over 90%, and CH4 increased with dilution quadratically. Overall, reducing solids in manure by dilution had the biggest impact on reducing odor and increasing organic C degradation.
Biofortification of pea (Pisum sativum L.): a review
Authors: Guindon María Fernanda , Cazzola Federico , Palacios Tatiana , Gatti Ileana , Bermejo Carolina , Cointry Enrique 
Published: January 2021

AbstractBiofortification refers to an approach to increase micronutrient concentrations in the edible parts of plants with increased bioavailability to the human population. Conventional, agronomic and transgenic breeding methods can be used to develop these biofortified crops, offering sustainable and cost‐effective strategies. Pea has long been recognized as a valuable, nutritious food for the human diet, but there is a limited amount of information about it, which prevents the full micronutrient enrichment potential of this pulse crop to be reached. Considerations must include not only micronutrient concentrations but also the amount of the nutrient that can be absorbed by the consumer, after processing and cooking. Development of biofortified pea that retains nutrients during cooking and processing is not only essential for fighting micronutrient malnutrition, but also necessary to improve agricultural productivity. © 2021 Society of Chemical Industry
Physicochemical and transcriptomic responses of Lactobacillus brevisJLD715 to sodium selenite
Authors: Yang Xinyan , Dai Xiaofei , Jin Haonan , Lin Guangen , Wang Zhenghui , Song Yang , Zhang Wei , Man Chaoxin , Jiang Yujun 
Published: January 2021

AbstractBACKGROUNDElemental selenium, as a new type of selenium supplement, can be prepared by microorganisms reducing inorganic selenium. In this study, Lactobacillus brevis JLD715 was incubated in broth containing different concentrations of sodium selenite (Na2SeO3).RESULTSThe results showed that the bacterial biomass of L. brevis JLD715 decreased due to the inhibition of Na2SeO3. The cell membrane of L. brevis JLD715 treated with Na2SeO3 was damaged, as evidenced by the reduction of intracellular ATP concentration, depolarization of cell membrane, reduction of intracellular pH and impairment of membrane integrity. In addition, we investigated the metabolism mechanism of Na2SeO3 by L. brevis JLD715 based on transcriptome sequencing. A total of 461 genes were significantly differentially expressed under Na2SeO3 treatment, of which 231 genes were up‐regulated and 230 genes were down‐regulated. These genes were involved in pathways such as pyruvate metabolism, fatty acid biosynthesis, selenocompound metabolism and nucleotide‐binding oligomerization domain‐like (NOD‐like) receptor signaling. Meanwhile, the genes related to sulfhydryl oxidoreductase, electron carrier proteins and transmembrane transport proteins synthesis were significantly up‐regulated.CONCLUSIONTo sum up, the findings of this research will contribute to providing support for the application of L. brevis JLD715 in selenium‐enriched functional foods. © 2021 Society of Chemical Industry
Spatiotemporal variation in coral recruitment and its association with seawater temperature
Authors: Edmunds Peter J. 
Published: January 2021

AbstractThe supply of propagules mediates recruitment and population dynamics, thereby driving community resilience following disturbances. These relationships are of interest on tropical reefs, where coral populations have drastically declined in abundance and sexual recruitment is the only means by which they will recover. To better understand the causes and implications of variation in this vital rate (i.e., recruitment), coral recruitment was measured in Mo'orea, French Polynesia, and St. John, U.S. Virgin Islands, using settlement tiles deployed from 2005 to 2019. The results were used to test two hypotheses: (1) annual variation in recruitment is a weak predictor of long‐term variation in recruitment, but (2) it is associated with seawater temperature. Coral recruitment varied over space and time, so that differences in recruitment between consecutive years were uninformative of long‐term trends. Recruitment varied among years in an apparently chaotic manner, but the variation reflected linear and quadratic associations with mean annual temperature and the daily variation in temperature. These associations are consistent with theory addressing the mechanisms by which temperature affects coral larvae and recruitment. Comprehension of these mechanisms is required to accurately interpret evidence of coral recruitment collapse, and to elucidate the conditions favoring recovery of coral communities through recruitment.
Sesamol‐based terpenoids as promising bio‐sourced crop protection compounds against the wheat pathogen Zymoseptoria tritici
Authors: Damiens Audrey , Alebrahim Mohammad Taghi , Léonard Estelle , Fayeulle Antoine , Furman Christophe , Hilbert Jean‐Louis , Siah Ali , Billamboz Muriel 
Published: January 2021

AbstractBACKGROUNDResearch into environmentally friendly alternatives to conventional plant protection products, to promote sustainable agriculture and healthy food, is strongly encouraged.RESULTSIn this context, 20 naturally occurring terpenoids and phenolic compounds were selected and evaluated in vitro as crop protection compounds against Zymoseptoria tritici, the causal agent of Septoria tritici blotch of wheat. After selection of the most active compounds, some hemisynthetic modifications were conducted to modify their lipophilicity. These modifications led to the discovery of sesamol esters as promising antifungal agents, with IC50 around 10 μg/mL and a total absence of cytotoxicity against human cells.CONCLUSIONThese sesamol‐based derivatives should be selected for further evaluations in planta to validate their use as wheat crop protection agents. Moreover, the importance of a balanced hydrophily/lipophilicity ratio should be further studied. © 2021 Society of Chemical Industry
Cooperative acoustic navigation of underwater vehicles without a DVL utilizing a dynamic process model: Theory and field evaluation
Authors: Harris Zachary J. , Whitcomb Louis L. 
Published: January 2021

AbstractThis paper reports the theoretical development and at‐sea field evaluation of a novel combined underwater acoustic communication and navigation system, known as cooperative acoustic navigation (CAN), for underwater vehicles (UVs) utilizing a second‐order dynamic plant model of the submerged UVs. The present state‐of‐the‐art in CAN is to utilize one‐way travel‐time acoustic modem telemetry together with purely kinematic, constant‐velocity plant process models. We term this approach CAN‐KIN. At present, CAN‐KIN is utilized with an on‐board bottom‐lock Doppler velocity log (DVL) providing frequent, high‐accuracy velocity corrections. However, DVLs are relatively expensive, have significant power requirements, can be physically large, and have limited acoustic bottom‐lock range, which restricts their use to a maximum of 25–420 m above the sea floor. In this study, we investigate the utility of a second‐order dynamic UV plant process model in CAN of UVs equipped with an acoustic modem, attitude, and depth sensors, but lacking a DVL, and a surface ship equipped with an acoustic modem and global positioning system. We term CAN utilizing a dynamic model CAN‐DYN. This paper reports results from at‐sea field trials conducted in the Chesapeake Bay with the Johns Hopkins University Iver3 UV. These experimental results indicate the submerged UV position estimate from CAN‐KIN is poor and even unstable in the absence of DVL velocity observations. These field experimental results also show that CAN‐DYN performs well without a DVL. Our results suggest CAN‐DYN without a DVL does not exhibit instability as does CAN‐KIN without a DVL, performs similarly to CAN‐KIN with a DVL, and outperforms DVL‐based dead reckoning. Additionally, we report an experimental evaluation of the effect of adding (relative) velocity corrections in the form of acoustic range‐rate observations to CAN utilizing a dynamic model without a DVL. We conclude that the addition of infrequent velocity observations, such as those provided by acoustic range rate, does not appear to improve the performance of CAN‐DYN without a DVL.