bluuebunny/crossref_metadata_2025_split huggingface dataset:
LRP4 mediated synaptic plasticity in the piriform cortex
Authors: Yan Min , Jing Hongyang , Xiong Mingtao , Lin Dong , Chen Peng , Chen Jiang , Liu Ziyang , Zhang Hang , Ren Dongyan , Fei Erkang , Lai Xinsheng , Zou Suqi , Wang Shunqi 
Published: May 2021

Abstract
Background

Low-density lipoprotein receptor-related protein 4(LRP4) plays a critical role in the central nervous system (CNS), including hippocampal synaptic plasticity, maintenance of excitatory synaptic transmission, fear regulation, as well as long-term enhancement.
Results

In this study, we found that Lrp4 was highly expressed in the piriform cortex and located in the second layer of the piriform cortex. When the transmembrane domain (TMD) and the intracellular domain (ICD) were missing, the Lrp4ECD/ECD mice appeared to be smaller, and the brain’s weight decreased, compared with the control mice. Simultaneously, finding food was prolonged for Lrp4ECD/ECD mice in the buried food-seeking test. In the piriform cortex of Lrp4ECD/ECD mice, the spine density of layer Ⅱ increased, and the frequency of both miniature excitatory postsynaptic current (mEPSC) and spontaneous excitatory postsynaptic current (sEPSC) enhanced.
Conclusions

This study indicated that LRP4 mediated synaptic plasticity in the piriform cortex. Moreover, it also suggested that TMD and ICD of LRP4 are nonnegligible for the LRP4 function in the piriform cortex.
Male breast cancer and female breast cancer: A population-based study
Authors: Yao Nan , Shi Wenzai , Liu Tong , Siyin Sarah Tan , Wang Weiqi , Duan Ning , Xu Guoshuai , Qu Jun 
Published: May 2021

Abstract
Male breast cancer (MBC) is a rare disease. Due to limited information, MBC has always been understudied. We conducted a retrospective population-based cohort study by using the 2010–2014 Surveillance, Epidemiology, and End Results (SEER) program data. The clinical and biological features of female breast cancer (FBC) patients were compared with MBC patients. Survival curves were constructed with the Kaplan-Meier method. Multivariate Cox regression models and competitive risk models were separately built to identify factors associated with survival time in the MBC and FBC group. Our retrospective study showed that MBC patients suffered with higher TNM stages, higher grades, and more percent of hormone receptor–positive tumors, compared with FBC patients. In addition, the site of the primary breast cancer varied greatly different between genders. FBC patients demonstrated superior overall survival than MBC patients on Kaplan-Meier analysis. In multivariate COX analysis for FBC patients, older age, black race, higher T, N, M-stages, higher grades, estrogen receptor (ER)/progesterone receptor (PR) negative and human epidermal growth factor receptor 2 (HER2) negative were associated with higher risk of death. MBC patients had similar independent prognostic factors, but PR and HER-2 status did not appear to independently influence survival. Interestingly, primary site location was an independent prognostic factor for both MBC patients and FBC patients, which should be considered by clinicians as a prognostic factor.
Target prediction of anti-chronic liver injury of Kangxian pill based on network pharmacology
Authors: Cao Min , Wang Yiyang , Liu Haizhao , Dong Xueqian , Dong Mengxue , Jin Yutong , Wang Jida , Jia Beitian , Bian Yuhong , Wang Li 
Published: May 2021

Abstract
BackgroundThe present study aimed to validate the protect effect of Kangxian pill (KXP) on chronic hepatic injury (CHI) and investigate its potential mechanism by network pharmacology-based prediction and experimental verification in vivo . MethodsThe effect of KXP in the treatment of carbon tetrachloride (CCL 4 )-induced CHI is investigated by calculating liver index, measuring AST and ALT levels and performing HE staining. Targets of active ingredients of KXP were predicted in TCSMP and targets of chronic liver injury were searched in DisGeNET, OMIM and GeneCards databases. We obtain some pivotal targets of KXP for the treatment of CHI by intersecting the targets of KXP and CHI. Subsequently, we performed gene ontology (GO) functional and pathways enrichment analyses, as well as conducted networks based on potential targets to determine the core targets and representative pathways.We further validated expressions of IL-6, IL-1β, TNF-α, Bax, Bcl2, PI3K, Akt, and pAkt according to the potential molecular mechanisms analyzed based on network pharmacology analysis.ResultsThe results showed that the levels of AST and ALT in serum decreased after treatment with KXP. HE staining also revealed that KXP could improve hepatocyte abnormality in vivo . A total of 81 potential targets of KXP in the treatment of CHI were identified through network pharmacology analysis. After integrating potential targets, function enrichment, representative pathways and networks, we identified PI3K, AKT1,BCL2, TNF-α, IL-1β, and IL-6 as potential targets, which may play a vital role in the KXP treatment. The experimental results also showed that KXP could down-regulate the mRNA and protein expression of IL-1β, IL-6, TNF-α and Bax, and up-regulate the PI3K and p-Akt protein expression i n vivo .ConclusionsOur results suggest that KXP could alleviate CHI through regulating inflammation and apoptosis and provide deep insight into the hepato-protective mechanisms.
Mast Cell Sensitization as a Plausible and Researchable Mechanism for Chemical Intolerance
Authors: Miller Claudia S. , Palmer Raymond F , Dempsey Tania T. , Ashford Nicholas A. , Afrin Lawrence B. 
Published: May 2021

Abstract
Background

Worldwide observations provide evidence for a two-stage disease process called Toxicant-Induced Loss of Tolerance (TILT), described in this journal in the first of two related papers. The disease process is initiated by a major exposure event, or a series of lower level exposures (Stage I, Initiation). Subsequently, affected individuals report that common chemical inhalants, foods, and drugs trigger multisystem symptoms (Stage II, Triggering). Given that foods and drugs also are comprised of chemicals, we refer to these intolerances simply as “chemical intolerance” (CI). In this second, companion paper we propose mast cell sensitization and mediator release as a plausible and researchable biological explanation for TILT.
Methods

Using the Quick Environmental Exposure and Sensitivity Inventory (QEESI), we compared patients diagnosed with mast cell activation syndrome (MCAS) (n = 147) to individuals who reported chemical intolerances following various exposures (n = 345), and to controls (n = 76). We compared QEESI scores using ANOVA across groups. Clinical scores for the MCAS patient group were used to predict CI status using logistic regression.
Results

As the likelihood of patients’ having CI increased, their likelihood of having MCAS similarly increased, to a near-perfect correspondence at the high ends of the QEESI and clinical MCAS scores. Symptom patterns were near-identical for CI and MCAS groups.
Conclusion

The close correspondence between QEESI scores for MCAS and TILT patients supports mast cell sensitization and mediator release as a plausible biological mechanism underlying both conditions, with implications for medicine, environmental health, and regulatory toxicology.
Atypical Processing Pattern of Gaze Cues in Dynamic Situations in Autism Spectrum Disorders
Authors: Liu Jia , Hu Jinsheng , Li Songze , Li Qi , Zhao Xiaoning , Liu Ying , Liu Shuqing 
Published: May 2021

Abstract
Psychological studies have generally shown that individuals with Autism Spectrum Disorder (ASD) have specificity in the processing of social information by using static or abstract images. Yet, a recent study showed that there was no differ in their use of the added social or non-social cues in dynamic interactive situations. To establish the cause of the inconsistent results, we explored the processing pattern of gaze cues in individuals with ASD by using chase detection paradigm and eye-tracking methodologies. In this study, unlike typical controls, participants with ASD showed no detection advantage under the oriented condition. The results suggested that individuals with ASD may utilize an atypical processing pattern in dynamic interactive situations.
Failure Analysis and Control Measures of Deep Roadway with Composite Roof: A Case Study
Authors: LI Yongliang , Yang Renshu , Fang Shizheng , Lin Hai , Lu Shaojie , Zhu Ye , Wang Maosheng 
Published: May 2021

Abstract
There is great variation in the lithology and lamination thickness of composite roof in coal-measure strata; thus, the roof is prone to delamination and falling, and it is difficult to control the surrounding rock when developing roadway in such rock strata. In deep mining, the stress environment of surrounding rock is complex, and the mechanical response of the rock mass is different from that of the shallow rock mass. For composite-roof roadway excavated in deep rock mass, the key to safe and efficient production of the mine is ensuring the stability of the roadway. The present paper obtains typical failure characteristics and deformation and failure mechanisms of composite-roof roadway with a buried depth of 650 m at Zhaozhuang Coal Mine (Shanxi Province, China). On the basis of determining a reasonable cross-section shape of the roadway and according to the failure characteristics of the composite roof in different regions, the roof is divided into an unstable layer, metastable layer, and stable layer. The controlled unstable layer and metastable layer are regarded as a small structure while the stable layer is regarded as a large structure. A superimposed coupling support technology of large and small structures with a multi-level prestressed bearing arch formed by strong rock bolts and highly prestressed cable bolts is put forward. The support technology provides good application results in the field. The study thus provides theoretical support and technical guidance for ground control under similar geological conditions.
Barriers and Facilitators to Modern Contraception Among Married Women in Conflict Affected Town of Mogadishu, Somalia
Authors: Gele Abdi , Shrestha Mary , Khalif Fathia , Qureshi Samera 
Published: May 2021

Abstract
Background - With a maternal mortality ratio of 692 per 100,000 live births and modern contraception prevalence of 1%, understanding factors hindering Somali women from using modern contraception is key to developing and implementing locally adopted public health responses. The purpose of this qualitative study is to explore barriers and facilitators to the use of modern contraception among married women in Mogadishu. Methods - We conducted a qualitative study using semi-structured, in-depth interviews with 21 married women aged >18 years, living in different neighborhoods in Mogadishu between July—December 2018. We recruited the participants using a convenience sampling method. We used thematic analysis and adapted ecological model as a framework for the synthesis.Results – The findings show that systemic, individual and socio-cultural barriers hinder women’s ability to access modern contraception. Barriers identified by this study include: Health communication messages and contraceptive information provided by health providers, prevalent religious fallacies among women and fear of permanent infertility upon modern contraception. Conclusion - Training health providers in the principles of modern contraception, in addition to the medical ethics that govern their responsibility to provide correct and relevant information to their patients, is vital for increasing modern contraception use among Somali women. The findings of this study may be used for designing public health interventions that promote acceptance and the use of modern contraception among both women and men in Somalia.
Composition Optimization, High-temperature Stability and Thermal Cycling Performance of Sc-doped Gd2Zr2O7 Thermal Barrier Coatings: Theoretical and Experimental Studies
Authors: Guo Lei , Li Bowen , Cheng Yuxian , Wang Lu 
Published: May 2021

Abstract
Sc was doped into Gd2Zr2O7 for expanding the potential for thermal barrier coating (TBC) applications. According to first-principles calculation, the solid solution mechanism of Sc in Gd2Zr2O7 lattice was revealed, i.e., Sc first occupies the lattice interstitial sites followed by substituting for Gd, and the interstitial Sc concentration is less than 11.11%. By considering the mechanical and thermophysical properties comprehensively, the optimum Sc doping content was determined to be 16.67%, and this composition was selected to produce TBCs by air plasma spraying with YSZ as a bottom ceramic coating (Gd-Sc/YSZ TBC). After sintering at 1400 ℃ for 100 h, Gd-Sc coatings remain phase and structural stability indicative of excellent sintering resistance. By thermal cycling tests, Gd-Sc TBCs fails due to the low toughness and the interface reaction between Gd-Sc and boding coatings, while Gd-Sc/YSZ TBCs exhibit much longer thermal cycling lifetime, and the failure mode is YSZ coating cracking.
Superior Training Efficacy of Beginning Movement Load Training for the Baseball Throwers
Authors: Chou Wen-Yi , Ko Jih-Yang , Chen Shu-Fang , Wu Chia-Feng , Wu Kuan-Ting , Jhan Shun-Wun 
Published: May 2021

Abstract
Background : Superior shoulder motion with rotator cuff activation are essential for the performance of the throwing athletes. The present study compared the novel beginning movement load training (BMLT) and popular throwers ten program regarding the training efficacy of baseball throwers. We hypothesized that the BMLT contributed the superior training efficacy than popular throwers ten program. Methods : Forty adult baseball players were randomized into study group and control group equally. In study group, the cyclic shoulder motion was repeatedly operated 3 days in a week and lasted for 6 weeks using three different BMLT training machines. As for control group, three popular cyclic training in the throwers ten program were adopted for the shoulder trainings as the same protocol in study group. The evaluations before and after training included the static range of motion (ROM), the maximal voluntary isometric contraction (MVICs) of the target muscle (pectoralis major, middle deltoid and supraspinatus) and throwing velocity. Result : After 6-week course, study group had significant wider static ROM in saggital adduction (p=0.034), coronal internal rotation (p=0.038) and external rotation (p=0.04) than in control group. The maximal voluntary isometric contraction (MVIC) ratio of middle deltoid/supraspinatus was significant lower in study group (Study : Control = 1.14±0.76 : 3.56 ±5.57, p = 0.044) which indicated the enhanced supraspinatus maximal contraction in the study group after training. In addition, the study group had significant improvement in throwing speed (117±10 vs 109±10 Km/hr, p=0.031). Conclusion : The BMLT contributed the superiority in range of motion, recruitment of supraspinatus and throwing velocity than the popular thrower`s ten program. It could be a favourable training for the overhead activity.
Survival Benefits After Surgery of Renal Cell Carcinoma Patients with Inferior Vena Cava Thrombus
Authors: Taweemonkongsap Tawatchai , Chotikawanich Ekkarin , Jitpraphai Siros , Woranisarakul Varat , Hansomwong Thitipat , Suk-Ouichai Chalairat 
Published: May 2021

Abstract
OBJECTIVE: To evaluate surgical and oncological outcomes after surgery in renal cell carcinoma (RCC) patients with inferior vena cava (IVC) tumor thrombus METHODS: A total of 58 patients from 2002 to 2019 underwent radical nephrectomy and IVC thrombectomy at Siriraj Hospital, Bangkok, Thailand, were retrospectively reviewed. Kaplan-Meier analysis was utilized to compare survival benefits between cohorts and Cox regression to evaluate predictors of patient survival. RESULTS: There were 5 (8.6%), 21 (36.2%), 23 (39.7%) and 9 (15.5%) patients with tumor thrombus level I, II, III and IV respectively. The major complications (Clavien 3-5) were observed in 15 patients (25.8%) and 80% were patients with high thrombus level (III-IV). There was 9% mortality (5 patients): 2 intraoperatively and 3 postoperatively. Median follow-up was 15 months (IQR:5-41). Two-year overall survival (OS) was 80% and 75% in all patients and pN0M0 cohort, respectively. There was significant difference in OS among each IVC thrombus level cohort (p<0.02). Two-year OS of metastatic RCC patients was 67% and not significantly different when compared to non-metastatic cohort (p=0.12). On multivariate analysis, only sarcomatoid dedifferentiation was associated with OS (p=0.04). Disease-free survival was not significantly different among thrombus-level cohorts (p=0.65). CONCLUSION: Our study suggested that surgical treatment for RCC with IVC thrombus provided acceptable OS outcomes, even in a small volume experience. Although the survival was significantly reduced with higher IVC thrombus level cohort, the level of thrombus itself was not an independent factor. Only sarcomatoid dedifferentiation was a predictor for OS after radical nephrectomy and tumor thrombectomy.
A Non-Field Analytical Method for Solving Some Nonlinear Problems in Heat Transfer
Authors: Kulish Vladimir , Sláma Pavel 
Published: May 2021

Abstract
This paper presents an extension of the non-field analytical method – known as the method of Kulish – to some nonlinear problems in heat transfer. In view of the fact that solving nonlinear problems is very complicated in general, the extension of the method is presented in the form of several important illustrative examples. Two classes of problems are considered: first are the problems, in which the heat equation contains nonlinear terms, while the second type of the problems includes some problems with nonlinear boundary conditions. From the practical viewpoint, the case considered in Section 4 is of the greatest interest. In that section, it is shown that, for complex heat transfer problems, where applications of the non-field method are practically impossible due to a large volume of necessary computations, it is still possible to analyse the solution behaviour and automatically determine similarity criteria for the limiting values of the parameters. Wherever possible the obtained solutions are compared with known solutions obtained by other methods. The practical advantages of the non-field method over other analytical methods are emphasised in each case.
A spatiotemporal ensemble machine learning framework for generating land use / land cover time-series maps for Europe (2000 – 2019) based on LUCAS, CORINE and GLAD Landsat
Authors: Witjes Martijn , Parente Leandro , Diemen Chris J. van , Hengl Tomislav , Landa Martin , Brodsky Lukas , Halounova Lena , Krizan Josip , Antonic Luka , Ilie Codrina M , Craciunescu Vasile , Kilibarda Milan , Antonijevic Ognjen , Glusica Luka 
Published: May 2021

Abstract
A seamless spatiotemporal machine learning framework for automated prediction, uncertainty assessment, and analysis of land use / land cover (LULC) dynamics is presented. The framework includes: (1) harmonization and preprocessing of high-resolution spatial and spatiotemporal covariate datasets (GLAD Landsat, NPP/VIIRS) including 5 million harmonized LUCAS and CORINE Land Cover-derived training samples, (2) model building based on spatial k-fold cross-validation and hyper-parameter optimization, (3) prediction of the most probable class, class probabilities and uncertainty per pixel, (4) LULC change analysis on time-series of produced maps. The spatiotemporal ensemble model was fitted by combining random forest, gradient boosted trees, and artificial neural network, with logistic regressor as meta-learner. The results show that the most important covariates for mapping LULC in Europe are: seasonal aggregates of Landsat green and near-infrared bands, multiple Landsat-derived spectral indices, and elevation. Spatial cross-validation of the model indicates consistent performance across multiple years with 62%, 70%, and 87% accuracy when predicting 33 (level-3), 14 (level-2), and 5 classes (level-1); with artificial surface classes such as 'airports' and 'railroads' showing the lowest match with validation points. The spatiotemporal model outperforms spatial models on known-year classification by 2.7% and unknown-year classification by 3.5%. Results of the accuracy assessment using 48,365 independent test samples shows 87% match with the validation points. Results of time-series analysis (time-series of LULC probabilities and NDVI images) suggest gradual deforestation trends in large parts of Sweden, the Alps, and Scotland. An advantage of using spatiotemporal ML is that the fitted model can be used to predict LULC in years that were not included in its training dataset, allowing generalization to past and future periods, e.g. to predict land cover for years prior to 2000 and beyond 2020. The generated land cover time-series data stack (ODSE-LULC), including the training points, is publicly available via the Open Data Science (ODS)-Europe Viewer.
Effects of first- and third-person perspectives created using a head-mounted display on dart-throwing accuracy
Authors: Ueyama Yuki , Harada Masanori 
Published: May 2021

Abstract
The first-person perspective (1PP) and third-person perspective (3PP) have both been adopted in video games. The 1PP can induce a strong sense of immersion, and the 3PP allows players to perceive distances easily. Virtual reality (VR) technologies have also adopted both perspectives to facilitate skill acquisition. However, how 1PP and 3PP views affect motor skills in the real world, as opposed to in games and virtual environments, remains unclear. This study examined the effects of the 1PP and 3PP on real-world dart-throwing accuracy after head-mounted display (HMD)-based practice tasks involving either the 1PP or 3PP. The 1PP group showed poorer dart-throwing performance, whereas the 3PP task had no effect on performance. Furthermore, while the effect of the 1PP task persisted for some time, that of task 3PP disappeared immediately. Therefore, the effects of 1PP VR practice tasks on motor control transfer more readily to the real world than do those of 3PP tasks.
SEMIOTIC ANALYSIS OF HOTEL ADVERTISEMENT
Authors: Km Tri Sutrisna Agustia  
Published: May 2021

The phenomenon of misinterpretation and the mismatch of the desired meaning in a hotel advertisement gives significant losses to hoteliers in Bali. The purpose of this study is to understand the meaning contained in a hotel promotion advertisement. This study aims to align the problem of conveying meaning in promotional advertisements that are often not understood by tourist targets so that there is a misunderstanding between the wishes of the hotel marketing and the needs of the tourists themselves. This study analyzes (1) ads part segmentation, (2) describes the relationship between signs in the form of markers and signs in hotel advertisements, (3) describes and provides an overview of suggestions regarding the role of the proper meaning in hospitality advertisements. The design of this study uses a qualitative design collected from study subjects in the form of hotel advertisements collected from promotional advertisements (brochures or websites) of hotels in Bali. The objects in this study are in the form of words, phrases, sentences, and images in the advertisements. The study stage begins with data collection on hotel advertisements regarding the advertisements being promoted. Then a picture of the proper meaning of promotional advertising based on semiotics will be drawn up. The results achieved are the connection between symbols and meanings used in a hotel promotion advertisement. Semiotic science variables can be added in the design of a hotel advertisement so that it provides an illustration of the suitability between the application of semiotics and hotel marketing practices as outlined in the advertisement. The exact match between the desires and the meaning to be conveyed can be developed properly to avoid misunderstandings between the hotel and the target market.
Keywords: advertising; Bali; hospitality; promotion; semiotics