bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transient Receptor Potential Melastatin 8 Contributes to Cystitis-Induced Neuronal Sprouting and Pain Hypersensitivity Through AKT/Mtor Signaling Pathway in Interstitial Cystitis/ Bladder Pain Syndrome
Authors: Wu Liyang , Zhou Fei , Zhang Jianzhong , Chang Ran , Wang Fei , Zhang Zhaohua , Zhang Peng 
Published: November 2021

Abstract
Transient receptor potential melastatin 8 (TRPM8) is associated with the pathophysiology of interstitial cystitis (IC)/ bladder pain syndrome (BPS). We investigated the mechanism of TRPM8 in neuroproliferation and pain, as well as the relevance of the Akt/mTOR signaling pathway in mice with IC/BPS. The model of IC/BPS was established in wild and TRPM8-/- mice. The mechanical sensitivity was measured. The number of neurite segments, length of neurites, and density of neurites were all counted. IL-6 and norepinephrine levels were detected by ELISA, Western blot was used to detect protein levels of TRPM8, Akt, p-Akt, mTOR, p-mTOR. Immunofluorescence was used to detect TRPM8 expression and distribution in neurites, neurons, and sensory nerves in mouse bladder tissue. Pain threshold in the IC / BPS group was decreased, and neurite segments, length, and density were all significantly enhanced when compared to the control group. The parameters in the TRPM8 agonists(menthol)+IC/BPS group were more statistically significant. Neurite number and density were lower in TRPM8-/-+IC/BPS mice than in IC/BPS mice. The expression of TRPM8 and the ratios of p-Akt/Akt and p-mTOR/mTOR rose in the IC/BPS group. In TRPM8-/-+IC/BPS mice, the ratios of p-Akt/Akt and p-mTOR/mTOR were not substantially different from those in the control group. TRPM8-/-+IC/BPS mice had considerably lower levels of serum IL-6 and urine norepinephrine than wild-type IC/BPS mice. TRPM8 can induce pain hypersensitivity and sensory nerve proliferation by activating Akt/mTOR pathway and raising the expression of IL-6 and norepinephrine in IC/BPS models. These findings offer new perspectives on IC/BPS treatment.
Mothers’ Knowledge And Attitude Towards Infant And Young Child Feeding Practices In Shashemene City, Oromia- Ethiopia 2020
Authors: Ahmed Junayde Abdurahmen , Kumsa Kebede , Hussen Kelil , Yalew Aster 
Published: November 2021

Abstract
The scheme youngsters are fed has a huge impact on their development. Poor breastfeeding and infant feeding practices have a negative impact on children's health and nutritional status.Purpose: The study's aim was to analyze mothers’ knowledge, attitudes, and practices (KAP) regarding supplemental feeding of children aged 6–23 months in Shashamene City, Oromia Ethiopia.Methods : A community based cross-sectional study was conducted from January 1-january 28 using a two-stage sampling procès to chose 536 women with children aged 6 to 23 months for the study. The Statistical Package for the Social Sciences (SPSS) software were used to analyze the data. The characteristics related with complementary feeding (CF) practice were identified using logistic regression, and statistical significance was determined at p-value of less than 0.05.Results: This study found that complementary food was first introduced at the age of 6 months, 353 (68.4 %) and 167 (32.1 %) at greater and Less than 6 months age with bottle feeding (AOR: 0.27, 95 % CI: (0.13, 0.55)). Sources of information about the advantages of breast milk (AOR:4.3495 % CI (1.96,9.60)), minimum dietary diversity (AOR:2.21,95 % CI(1.01,4.85)), knowledge about iron-rich foods (AOR:0.029,95 % CI (0.04,0.21)), knowledge about iodine-rich foods (AOR:0.022,95 % CI (0.03,0.16)) were discovered to be independent predictors of mother’s knowledge on appropriate infant feedingConclusion: Mothers' knowledge about the timing of CF practices is low in this study. Botte feeding, sources of information about the benefits of breast Milk, a minimum dietary diversity, knowledge about infant and young child feeding were the indépendant factors that significantly associated with mother's knowledge of appropriate infant and Young Child feeding practices.
Sero epidemiology of Cattle Brucellosis and Associated Risk Factors in Amibara District of Afar Region, Ethiopia
Authors: Wegi Fekadu Gutema , Bekele Juhar Tesfaye 
Published: November 2021

Abstract
Bovine brucellosis is the most common but under reported bacterial diseases known to create a serious socio-economic problem in both intensive and extensive livestock production systems. A cross-sectional study was conducted to determine seroprevalence and associated risk factors of cattle brucellosis in Amibara district of Afar region, Ethiopia from October 2019 to May 2020. A total of 181 cattle sera were collected and screened using Rose Bengal Plate Test (RBPT) and reactive samples were further confirmed by complement fixation test (CFT). Risk factors associated with cattle brucellosis were assessed during serum sample collection using data collection format. As a result, the overall seroprevalence of cattle brucellosis was 10.5% and 2.2% by RBPT and CFT respectively. Assessment of potential risk factors showed that, Age (χ2=6.77, p=0.021), number of parity (χ2=9.433, p=0.004), abortion history (χ2=16, p=0.002) and history of placental retention (χ2=19.1, p=0.003) showed statistically significant association with brucellosis seropositivity in cattle. Based on firth’s bias reduced logistic regression analysis, only multiparous animal (OR=10.68, P=0.0042, 95% CI=-1.19-7.595) and animals with placental retention (OR=72.72, P=0.0026, 95% CI=1.46-9.272) showed statistically significantly association with brucella infection in cattle. In conclusion, the results of the current study indicate the presence of brucellosis in cattle in Amibara district of Afar region, Ethiopia. Hence, implementing preventive measures such as developing vaccination strategy, regular screening and culling of the reactive animal is important to create diseases free herd.
A Locking Plate Designed With Cluster of Head Screws Would Be Biomechanically Superior Than Conventional Buttress Plate For The Fixation of Posteromedial Tibial Plateau Fractures: A Computational Assessment
Authors: Lin Kai-Cheng , Tarng Yih-Wen , Lin Kun-Jhih , Wei Hung-Wen 
Published: November 2021

Abstract
Background: Dealing with high-energy fractures of the tibial plateau remains a challenge despite advances in implants, surgical approaches, and imaging methods. Posterior buttress plate is most commonly used implant but the fixation stability is still a challenge. Recently, a newly designed tibial locking plate was introduced that aims to provide better fixation strength for tibial plateau split fracture. This study compared the biomechanical strength of three different posteromedial tibial plateau split fracture fixation methods. Methods: The tibial plateau fractures were simulated using a human tibiae model. Each fracture model was virtually implanted with one of the three following constructs, proximal medial tibial plate (PMT), proximal posterior medial tibial plate (PPMT), and posterior T-shaped buttress plate (TBP). Posteromedial fragment vertical subsidence was measured under 2000 N joint contact force. The maximum Equivalent stress on the bone plate and bone screw and the construct stiffness were determined.Results: The proximal medial tibial plate (PMT) allowed the least posteromedial fragment subsidence and produced higher construct stiffness than each of the other two constructs. However, the proximal posterior medial tibial plate (PPMT) showed higher stiffness than the T-shaped buttress plate (TBP). The maximum Equivalent stress was the smallest for the proximal medial tibial plate (PMT).Conclusion: This study showed that the proximal medial tibial locking plate or proximal posterior medial tibial locking plate were biomechanically more stable fixation methods for posteromedial split tibial plateau fractures.
Towards Data-Driven Evaluation of Site Effects From Coda of Strong Motion Timeseries Using Recurrent Neural Networks
Authors: Izadi Mona , Matsushima Shinichi 
Published: November 2021

Abstract
It is known that coda of strong motion records are products of numerous scatterings of body and surface waves within the subsurface soil structure. Several studies have successfully simulated coda wave envelopes by modelling the energy decay. However, due to limitations of quantifying soil heterogeneities, deterministic simulation of scattered wavefields is much more challenging. Therefore, the reverse problem of estimating non statistical properties of subsurface structure from coda waves remains a theoretical potential. On the other hand, machine learning techniques have proven useful in dealing with problems of similar nature, where a theoretical solution is imaginable yet hard to achieve due to a great number of unknown variables. This study utilizes artificial neural networks to propose a new approach of evaluating site effects from coda waves, with the future prospect of obtaining the similar results from microtremor records. A Long Short-Term Memory recurrent neural network is designed using Tensorflow 2 library in Python language. The study utilizes a strong motion dataset consisting of about 60000 3-component records as well as borehole data at 464 stations of Kiban-Kyoshin Network across Japan. The prediction input is coda wave timeseries of strong motion records, defined based on a parametric energy criterion, and all 3 seismograph components EW, NS and UD are used as parallel sequential features. In the first step, the prediction target is a vector of 3 site effect proxies namely, time-averaged shear-wave velocities for the upper 30-m depth Vs30 and the upper 10-m depth Vs10 and predominant frequency f0. In this step, different model parameter combinations are tested to ensure the basic model’s ability in extracting site-specific information from the input coda waves. One of the combinations is then used in the second step, in which the prediction target is surface to downhole ratio of Fourier Amplitude Spectra. For each of the 3 components EW, NS and UD, 100 identical networks are trained to each predict the desired ratio at a certain target frequency. Accuracy of test sample predictions confirms applicability of the proposed approach as well as its potential for future works on microtremor timeseries instead of coda waves.
Proteomic Analysis of Glomerular Proteins in Primary and Bucillamine-induced Membranous Nephropathy
Authors: Kaga Hajime , Matsumura Hirotoshi , Suzuki Takehiro , Dohmae Naoshi , Odaka Masafumi , Komatsuda Atsushi , Takahashi Naoto , Wakui Hideki 
Published: November 2021

Abstract
The aim of this study was to characterize glomerular proteins in primary membranous nephropathy (pMN) and drug-induced secondary MN (sMN) by laser microdissection and comparative proteomic analysis. We used renal biopsy specimens from 6 patients with anti-phospholipase A2 receptor autoantibody (PLA2R Ab) (+) pMN, 6 patients with PLA2R Ab (‒) pMN, 6 patients with bucillamine (BCL)-induced sMN, and 5 control cases (time 0 transplant biopsies). Proteins were extracted from laser-microdissected glomeruli and analyzed using mass spectrometry. The quantification values of protein abundance in each MN group were compared with those in the control group. More than 800 proteins with high confidence were identified. Principal component analysis revealed a different distribution between the pMN and sMN groups. For further analysis, 441 proteins matched with ≥3 peptides were selected. Among the pMN and sMN groups, we compared the profiles of several protein groups based on the structural and functional characteristics, such as immunoglobulins, complements, complement-regulating proteins, podocyte-associated proteins, glomerular basement membrane proteins, and several proteins that are known to be associated with kidney diseases, including MN. Between the pMN and BCL-induced sMN groups, we observed common and different alterations in protein levels such as known disease-associated proteins and potential disease marker proteins.
A Tested Method for Assessing and Predicting Weather-Crime Associations
Authors: Algahtany Mofza , Kumar Lalit , Barclay Elaine 
Published: November 2021

Abstract
Few studies have focused on haze as a weather element and its correlation with crime. In this study, we examined haze as a weather variable to investigate its effects on criminal activity. We used both monthly crime data and weather records to build a regression model to predict crime cases considering three weather factors; temperature, humidity and haze. We applied this model in two different climate provinces in Saudi Arabia, namely, Riyadh and Makkah. Riyadh is a desert area and observes haze approximately 17 days per month on average, while Makkah is a coastal area observing haze an average of 4 days per month. We found a measurable relationship between each of these three variables and criminal activity. However, haze had the most effect on theft, drug and assault crimes in Riyadh compared to the other elements. Temperature and humidity have a significant relationship with crime in Makkah, while haze had no significant influence in that region.
Humic Acid Promotes the Adsorption of Lead onto PSMPs: Site Energy Distribution Theory and Fluorescence Quenching Analysis
Authors: Lu Xiaotian , Zeng Feng , Wei Shuyin , Gao Rui , Abdurahman Abliz , Wang Hao , Liang Weiqian 
Published: November 2021

Abstract
Microplastics (MPs) have a great potential to adsorb heavy metal pollutants such as Pb2+ and the dissolved organic matter(DOM) in the aquatic environment will affect this adsorption behavior. In this study, batch experiments were performed to investigate the adsorption characteristics of Pb2+ onto polystyrene microplastics (PSMPs) in the presence and absence of HA(a kind of representative DOM). The adsorption kinetics of Pb2+ onto PSMPs conformed to the pseudo-second order model, and the adsorption isotherms were well fitted by the Langmuir model. With the increase of HA concentration, the Pb2+ adsorption onto PSMPs increased. Site energy distribution analysis showed that the presence of HA increased the adsorption site energy of PSMPs, thus enhancing the adsorption capacity for Pb2+. The fluorescence quenching analysis of HA further indicated that part of HA were adsorbed onto PSMPs, which increased additional binding sites on the surface of PSMPs. This was attributed to the abundant functional groups that could react with Pb2+ of HA. The pH and ionic strength of solution changed the structure of HA and the adsorption sites of PSMPs, which influenced the adsorption capacity of PSMPs for Pb2+. This study illustrated the effect of HA on the process and mechanism of Pb2+ adsorption onto PSMPs, and provided more information for the evaluation of environmental behavior and toxicological effects of microplastics in aquatic environments.
Comparative Growth Performance and Carcass Traits of Calves of Different Cattle Breeds Fed Pasture and Concentration
Authors: Saeed Mahabad Ibrahim , Sabow Azad Behnan , Muhamad Aram Ahmad , Hermiz Hani Nasser 
Published: November 2021

Abstract
The aim of the current study was to explore growth performance and carcass traits using ultrasound measurements of calves of different cattle breeds under pasture and concentration feeding system. A total of 25 male cattle calves between the ages of 6 to 7 months with an average body weight of 162.37 ± 7.7 kg were fed two separate fattening trials for seven months (pasture and finishing period). Animals were divided into five groups (five of each breed): Kurdi, Rustaki, Jenoubi, Herford and Friesian crossbred. The average daily weight gain was similar (P > 0.05) for calves of different cattle breeds during growth (pasture) period, while these values were significantly higher in Kurdi, Rustaki and Friesian crossbred calves during finishing period. The body size measurements were similar among calves of different cattle breeds. The highest increase in Longissimus muscle area and subcutaneous fat thickness was observed in Kurdi, Rustaki and Friesian crossbred calves. In conclusion, In conclusion, Kurdi, Rustaki and Friesian crossbred calves possess the promising potential for beef production under the barn rearing or finishing period.
Modelo web semántico para contactar grupos musicales en la ciudad de Bogotá
Authors: Katz Delgado Juan Esteban , Espinel Ortega Álvaro , Vega Escobar Adriana Marcela 
Published: November 2021

La presente investigación muestra el desarrollo de un modelo web semántico cuyo objetivo es crear una base de conocimiento de grupos y géneros musicales tradicionales de la ciudad de Bogotá, la forma en la que se transmite la información hacia y desde la base de conocimiento creada, es mediante el uso de un API basado en arquitectura REST, que utiliza el protocolo HTTP, esta información se presenta en un portal Web.
Los visitantes y usuarios que ingresen al portal pueden realizar búsquedas que son basadas en SPARQL, para contactar grupos musicales de acuerdo con una serie de filtros tales como: ubicación geográfica, género musical, trayectoria en el mercado, tarifas entre otros, este desarrollo se convierte en una alternativa digital para que los grupos musicales de la ciudad de Bogotá puedan promocionar sus servicios y generen un canal virtual de contacto rápido y seguro, con ello se busca mejorar la calidad de vida de los integrantes de agrupaciones musicales.
A Critical Review of Digital Marketing: Effect of Flow and Impulse Buying
Authors: Azizah Mt Rahmawati , Octavia Ria 
Published: November 2021

Abstract: This study aims to examine the influence of user belief on flow, willingness to buy on flow, and flow on impulse buying behavior. The subjects of this research include Students/College Students, Civil Servants, Private Employees, Lecturers/Teachers, Professionals (accountants, consultants, etc.). The technique used is non-probability sampling , purposive sampling, with a total sample of 300 respondents aged 17 to 45 and are users of the digital application, Shopee, in Indonesia. The research instrument was an online questionnaire and was analyzed using multiple linear regression analysis. The results of this study showed that the dimension of the perceived usefulness of user belief has a positive effect on flow. Willingness to buy has a positive effect on flow and flow has a positive effect on impulse buying. Meanwhile, the ease of use dimension of the user belief variable has no positive effect on flow.Keywords: flow, willingness to buy, user belief, impulse buying behavior. Tinjauan Kritis Pemasaran Digital: Pengaruh Flow dan Pembelian Impulsif Abstrak: Penilitian ini bertujuan untuk menguji pengaruh kepercayaan pengguna (user belief) terhadap flow, willingness to buy terhadap flow, dan flow terhadap perilaku pembelian spontan. Subjek penelitian ini meliputi Pelajar/Mahasiswa, PNS, Karyawan Swasta, Dosen/Guru, Profesional (akuntan, konsultan, dll). Teknik yang digunakan adalah non-probability sampling dengan jenis purposive sampling dengan kriteria usia 17 hingga 45 tahun dengan total sampel 300 responden dan merupakan pengguna aplikasi digital Shopee di Indonesia. Instrumen penelitian ini adalah kuesioner yang dibuat secara daring dan dianalisis dengan menggunakan analisis regresi linier berganda. Hasil penelitian ini menemukan bahwa dimensi manfaat yang dirasakan dari kepercayaan pengguna berpengaruh positif terhadap flow, willingness to buy berpengaruh positif terhadap flow dan flow berpengaruh positif terhadap pembelian spontan. Sedangkan, dimensi kemudahan menggunakan dari variabel kepercayaan pengguna tidak berpengaruh positif terhadap flow.Kata kunci: flow, willingness to buy, kepercayaan pengguna, perilaku pembelian spontan.
Population Health Surveillance Using Mobile Phone Surveys in Low- and Middle-Income Countries: Methodology and Sample Representativeness of a Cross-sectional Survey of Live Poultry Exposure in Bangladesh
Authors: Berry Isha , Mangtani Punam , Rahman Mahbubur , Khan Iqbal Ansary , Sarkar Sudipta , Naureen Tanzila , Greer Amy L , Morris Shaun K , Fisman David N , Flora Meerjady Sabrina 
Published: November 2021

Background
Population-based health surveys are typically conducted using face-to-face household interviews in low- and middle-income countries (LMICs). However, telephone-based surveys are cheaper, faster, and can provide greater access to hard-to-reach or remote populations. The rapid growth in mobile phone ownership in LMICs provides a unique opportunity to implement novel data collection methods for population health surveys.

Objective
This study aims to describe the development and population representativeness of a mobile phone survey measuring live poultry exposure in urban Bangladesh.

Methods
A population-based, cross-sectional, mobile phone survey was conducted between September and November 2019 in North and South Dhaka City Corporations (DCC), Bangladesh, to measure live poultry exposure using a stratified probability sampling design. Data were collected using a computer-assisted telephone interview platform. The call operational data were summarized, and the participant data were weighted by age, sex, and education to the 2011 census. The demographic distribution of the weighted sample was compared with external sources to assess population representativeness.

Results
A total of 5486 unique mobile phone numbers were dialed, with 1047 respondents completing the survey. The survey had an overall response rate of 52.2% (1047/2006) and a co-operation rate of 89.0% (1047/1176). Initial results comparing the sociodemographic profile of the survey sample to the census population showed that mobile phone sampling slightly underrepresented older individuals and overrepresented those with higher secondary education. After weighting, the demographic profile of the sample population matched well with the latest DCC census population profile.

Conclusions
Probability-based mobile phone survey sampling and data collection methods produced a population-representative sample with minimal adjustment in DCC, Bangladesh. Mobile phone–based surveys can offer an efficient, economic, and robust way to conduct surveillance for population health outcomes, which has important implications for improving population health surveillance in LMICs.
Adjusting to the Reign of Webinars: Viewpoint
Authors: Karabacak Mert , Ozkara Burak Berksu , Ozcan Zeynep 
Published: November 2021

Background
With the integration of COVID-19 into our lives, the way events are organized has changed. The Cerrahpaşa Neuroscience Days held on May 8-9, 2021, was one of the conferences that was affected. The annual conference of the student-based Cerrahpaşa Neuroscience Society transitioned to the internet for the first time and had the premise of going international.

Objective
With this study, we aim to both discuss how a virtual conference is organized and perceived, and where our conference stands within the literature as a completely student-organized event.

Methods
The conference was planned in accordance with virtual standards and promoted to primarily medical schools. During the execution, there were no major issues. The feedback was collected via a form developed with Google Forms.

Results
Out of 2195 registrations, 299 qualified to receive a certificate. The feedback forms revealed a general satisfaction; the overall quality of the event was rated an average of 4.6 out of 5, and the ratings of various Likert scale–based questions were statistically analyzed. Open-ended questions provided improvement suggestions for future events.

Conclusions
The virtual Cerrahpaşa Neuroscience Days was a success in organization and received positive feedback from the participants. We aim to ground future events on this experience.