bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic accuracy of maternal serum endothelial-derived nitric oxide synthase (eNOS) and its correlation with birth outcomes, in preeclampsia - a case-control study
Authors: Kashinakunti Sangappa Virupaxappa , Devaranavadagi Basavaraj , Rangappa Manjula , Mallapur Ashalata 
Published: September 2021

Introduction and Aim: Pre­eclampsia (PE) results from impaired placentation, leading to placental hypoxia and dysfunction and abnormalities in the endothelial nitric oxide synthase (eNOS)-nitric oxide pathway. The present study was undertaken to estimate and compare maternal serum eNOS concentrations in women with PE and normal healthy pregnant women, to know the correlation of eNOS level with severity of PE, to find the best cut-off value for the diagnosis of PE and to study its association of eNOS levels with the birth outcome.
Material and Methods: This was a case-control study, conducted at a tertiary care hospital. The study was approved by the Institutional ethics committee. Informed consent was obtained from all the participants. Primigravida (singleton) pregnant women aged 18-35 years, 20 or more weeks of gestation, diagnosed as PE and classified as mild/severe PE based on America college of obstetricians and gynecologists guidelines were selected for the study. eNOS was estimated by the ELISA method. All the participants were visited again to note the outcomes.
Results:The maternal serum eNOS in PE was significantly lower than the control group (p=0.019). The best cut-off value was 187.25pg/ml to diagnose PE, area under the ROC curve (AUC) 0.61, sensitivity 95.1%, specificity 37.5% and diagnostic accuracy was 66,67%. Birth outcomes did not have a significant correlation with eNOS.
Conclusion: eNOS was significantly lowerer in PE, it can be used as a diagnostic marker with the best cut of value of 187.25 pg/ml.
In silico docking analysis of selective bioactive compounds of Phyllanthus acidusaqueousfruit extractagainst MAPK1
Authors: Padmini E. , Kavitha M. 
Published: September 2021

Introduction and Aim: Phyllanthus acidus L.Skeels (Family: Phyllanthaceae) or Star Gooseberry which bears small, edible, juicy, sour, yellow berries fruit is known as a “liver tonic” in ayurvedic medicine. However, the behavior of the plant fruit or its constituents in cell apoptosis/cell survival is unknown. Hence, the purpose of thepresent study was to perform an in silico docking of selective bioactive compounds of aqueous extract of fruit of P.acidus (PAFAE) against MAPK1. Mitogen activated protein kinase is a family of serine threonine specific protein kinases- MAPK1/ERK1/2, JNK1-3, p38MAPK and ERK5.Activation ofMAPK1 promotes cell survival in certain tissues by inhibiting proapoptotic proteins and by stimulating anti apoptotic factors.

Methodology: In silico docking studies was carried out using bioinformatics tools.The active compounds (Trihomovitamin D3; 2Z,6Z,8Z,12E Hexadecatetraenoic acid, Methyl prednisolone, Hydroxysalmeterol and Tridesacetoxykhivorin) ofP.acidus aqueous fruit extract were docked against MAPK1 resulting in receptor-ligand complex.

Results: The binding energy is correlated with the probability of affinity and stable bound between ligand and its receptor.

Conclusion: The molecular docking study of selective bioactive compounds of PAFAE with MAPK1 protein revealed that Tridesacetoxykhivorinand Methyl Prednisolone, is having good interaction in favorable pose with MAPK1 as shownfrom theireffective binding energy(-7.79kcal/mol and -7.19 kcal/mol), strong bond length and interactions with active site of MAPK1.
CASE REPORT: COMPLICATION AT BOTH RECEIVING AND DONOR SITES IN FACIAL AUTOLOGOUS FAT TRANSFER
Authors: Ngoc Lam Vu , Thi Thu Hai Le , Phuong Tien Nguyen 
Published: September 2021

Autologous fat grafting is a technique that has been used for a long time in the field of plastic surgery. Besides many advantages, the complications, which can range from mild such as hematoma, infection, calcification, necrosis... even death is a big problem. The article presents a case of using autologous fat taken from the abdomen to graft onto the facial area with complications of severe infection in both the receiving and donor sites, causing necrosis of fat and skin in both areas. The treatment takes a long time with different procedures, but the consequences for the patient are still very serious both in terms of aesthetics and function. The objective of this study was to evaluate the safety and efficacy of fat grafting to the facial region for the reconstruction and aesthetic enhancement of facial contour.
MESENCHYMAL STEM CELL-BASED THERAPY FOR CHRONIC KIDNEY FAILURE RELATING LUPUS ERYTHEMATOSUS - A CASE REPORT
Authors: Duy Thang Nguyen , Thi Thuy Hoa Phan , Thi Dieu Ngan Phan , Nhat Hoang Ngo , Thi Cam Ha Che 
Published: September 2021

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, which is characterized by systemic multiple-organ involvement, relapses with large amount of autoantibodies. Their pathophysiology is multifaceted, involves complex hormonal-immunological-cellular interactions, and leads to damage in multiple cell types, which is often resistant to conventional therapy. Thus, novel strategies are needed to repair the renal parenchyma and preserve kidney function. Mesenchymal stem cells (MSC) confer renal protection through paracrine/endocrine effects, and to some degree possibly by direct engraftment. The patient was diagnosed with chronic kidney disease by standard methods for more than fifteen years. The patient agreed to the treatment of autologous adipose mesenchymal stem cell transplantation. The adipose mesenchymal stem cells were harvested by surgery, isolated with our enzyme protocol. The patient received one injection with 2,6x106 cells/kg for a total of 43kg of body weight. The patient with SLE do not receive prompt treatment, he get irreversible organ damage. After seven months, the preexisting renal insufficiency gradually ameliorated, including the decrease of creatinine and blood urea as well as the increase of estimated glomerular filtration rate. Lupus symptoms also reduced, followed by the improvement of body movement and medication reduction.There was insufficient evidence of the clinical setting to show the efficiency of mesenchymal stem cells on the lupus nephritis relating to chronic kidney disease. This clinical trial highlights the feasibility and safety of mesenchymal stem cell treatments in renal failure-associated- autoimmune diseases.
In memoriam. Ignacio Ellacuría, Juan Ramón Moreno, Amando López, Ignacio Martín-Baró, Segundo Montes, Joaquín López y López, Julia Elba y Celina Ramos
Authors: Latinoamericana de Teología Revista 
Published: September 2021

No hay resúmenes disponibles.
Revista latinoamericana de teología, Vol. 6, No. 18, 1989: 251-254.
IMPLEMENTATION OF THERAPEUTIC DRUG MONITORING IN INDONESIA
Authors: Sani Aluwi Nirwana 
Published: September 2021

Therapeutic Drug Monitoring (TDM) is the clinical pharma cy practice of measuring plasma level of drugs. This service is required to optimize the drug therapy in individual patient and should be considered an adjunct to physician’s clinical judgment in assessing the course and the effectiveness of treatment, especially in critically ill patients. Indonesia has not been developed this service. Therefore, this article discus the roles and function of a best practice TDM service and how can this service be implemented in Indonesia.
MENUMBUHKAN KREATIVITAS SISWA MELALUI PEMBELAJARAN GRAFIK FUNGSI EKSPONEN DENGAN PENDEKATAN OPEN-ENDED PROBLEM
Authors: PURWANTO EKO 
Published: September 2021

Standar Isi Kurikulum Tingkat Satuan Pendidikan (KTSP) mengamanatkan pentingnya menumbuhkan kreativitas siswa, kemampuan memiliki sikap kreatif dan berpikir kreatif melalui kegiatan kreatif dalam pembelajaran matematika. Salah satu cara yang dapat dilakukan untuk menumbuhkan kreativitas adalah melalui pembelajaran eksponen fungsi grafik dengan menggunakan pendekatan open-ended problem terhadap masalah tersebut. Pendekatan open-ended problem membutuhkan pemecahan masalah terbuka dan kreativitas siswa untuk memecahkan masalah dengan lebih dari satu jawaban yang benar. Proses penelitian menggunakan desain penelitian tindakan kelas yang bertujuan untuk menjelaskan pembelajaran grafik fungsi eksponen dengan pendekatan open-ended problem untuk menumbuhkan kreativitas siswa, yaitu aspek sikap kreatif dan berpikir kreatif siswa serta mengetahui respon siswa setelah diajar dengan menggunakan pendekatan open-ended problem. Sasaran penelitian adalah siswa kelas XII IPA SMA Negeri 1 Tanjung Selor tahun ajaran 2010/2011. Pengumpulan data melalui angket, lembar observasi, wawancara, dan tes. Berdasarkan hasil penelitian diperoleh bahwa pembelajaran grafik fungsi eksponen dengan pendekatan open-ended problem dapat menumbuhkan sikap kreatif dan berpikir kreatif siswa dengan persentase rata-rata 73,35% dari 30 siswa dan termasuk dalam kategori kreatif. Berdasarkan hasil tes akhir dan tugas siswa, diperoleh hasil bahwa rata-rata siswa mampu menjawab semua soal tes yang diujikan, walaupun tidak sepenuhnya benar, namun setidaknya siswa telah memberikan beberapa alternatif jawaban yang benar dalam menyelesaikan soal-soal tes yang diujikan. Aktivitas guru dalam pembelajaran memperoleh kategori sangat baik dengan persentase 88,3% dan respon siswa positif terhadap pembelajaran grafik fungsi eksponen melalui pendekatan open-ended problem dengan skor rata-rata kumulatif 4,49.
Structural changes to forests during regeneration affect water flux partitioning, water ages and hydrological connectivity: Insights from tracer-aided ecohydrological modelling
Authors: Neill Aaron J. , Birkel Christian , Maneta Marco P. , Tetzlaff Doerthe , Soulsby Chris 
Published: September 2021

Abstract. Increasing rates of biodiversity loss are adding momentum to efforts seeking to restore or rewild degraded landscapes. Here, we investigated the effects of natural forest regeneration on water flux partitioning, water ages and hydrological connectivity, using the tracer-aided ecohydrological model EcH2O-iso. The model was calibrated using ∼ 3.5 years of diverse ecohydrological and isotope data available for a catchment in the Scottish Highlands, an area where impetus for native pinewood regeneration is growing. We then simulated two land cover change scenarios that incorporated forests at early (dense thicket) and late (old open forest) stages of regeneration, respectively. Changes to forest structure (proportional vegetation cover, vegetation heights and leaf area index of pine trees) were modelled for each stage. The scenarios were then compared to a present-day baseline simulation. Establishment of thicket forest had substantial ecohydrological consequences for the catchment. Specifically, increased losses to transpiration and, in particular, interception evaporation drove reductions in below-canopy fluxes (soil evaporation, groundwater (GW) recharge and streamflow) and generally slower rates of water turnover. The greatest reductions in streamflow and connectivity were simulated for summer baseflows and small to moderate events during summer and the autumn/winter rewetting period. This resulted from the effect of local changes to flux partitioning in regenerating areas on the hillslopes extending to the wider catchment by reducing downslope GW subsidies that help sustain summer baseflows and saturation in the valley bottom. Meanwhile, higher flows were relatively less affected, especially in winter. Despite the generally drier state of the catchment, simulated water ages suggested that the increased transpiration demands of the thicket forest could be satisfied by moisture carried over from previous seasons. The more open nature of the old forest generally resulted in water fluxes, water ages and connectivity returning towards baseline conditions. Our work implies that the ecohydrological consequences of natural forest regeneration depend on the structural characteristics of the forest at different stages of development. Consequently, future land cover change investigations need to move beyond consideration of simple forest vs. non-forest scenarios to inform sustainable landscape restoration efforts.
Snow model comparison to simulate snow depth evolution and sublimation at point scale in the semi-arid Andes of Chile
Authors: Voordendag Annelies , Réveillet Marion , MacDonell Shelley , Lhermitte Stef 
Published: September 2021

Abstract. Physically based snow models provide valuable information on snow cover evolution and are therefore key to provide water availability projections. Yet, uncertainties related to snow modelling remain large as a result of differences in the representation of snow physics and meteorological forcing. While many studies focus on evaluating these uncertainties, no snow model comparison has been done in environments where sublimation is the main ablation process. This study evaluates a case study in the semi-arid Andes of Chile and aims to compare two snow models with different complexities, SNOWPACK and SnowModel, at a local point over one snow season and to evaluate their sensitivity relative to parameterisation and forcing. For that purpose, the two models are forced with (i) the most ideal set of input parameters, (ii) an ensemble of different physical parameterisations, and (iii) an ensemble of biased forcing.
Results indicate large uncertainties depending on forcing, the snow roughness length z0, albedo parameterisation, and fresh snow density parameterisation. The uncertainty caused by the forcing is directly related to the bias chosen. Even though the models show significant differences in their physical complexity, the snow model choice is of least importance, as the sensitivity of both models to the forcing data was on the same order of magnitude and highly influenced by the precipitation uncertainties. The sublimation ratio ranges are in agreement for the two models: 36.4 % to 80.7 % for SnowModel and 36.3 % to 86.0 % for SNOWPACK, and are related to the albedo parameterisation and snow roughness length choice for the two models.
Pengelolaan Wilayah Pesisir Secara Terpadu Dan Berkelanjutan Yang Berbasis Masyarakat
Authors: Kristian Indra 
Published: September 2021

Indonesia is an island nation with a total of 17,499 islands and a coastline length of approximately 81,000 km (DKP, 2008). This situation caused the coastal area to become a source of income for Indonesian society.
The utilization and management of coastal areas carried out by the community and the regions in part has not fulfilled the provisions of sustainable and sustainable use of natural resources. This will affect the condition and sustainability of the coast and its environment. Reclamation policies that are not based on environmental impact analysis in some regions also affect the coastal ecosystem. Licensing of business development for the business community has so far been largely the authority of the center. Coastal areas have strategic value for national economic development and improvement of people's welfare and at the same time are areas that are very vulnerable to damage and destruction. Wise management by placing economic interests in proportion to environmental interests, both in the short and long term.
Community-based management as a natural resource management system in a place where local communities are actively involved in the process of managing natural resources contained in it. The community development strategy can be carried out through two approaches, which are structural and non-structural.
PENGARUH KEPRIBADIAN (THE BIG FIVE PERSONALTY) TERHADAP REAKSI EMOSI PADA MAHASISWA SAAT KEGIATAN BELAJAR DARING
Authors: Revasika Sopianti , Robiyanto Oka Ivan 
Published: September 2021

Kepribadian merupakan sejumlah pola pemikiran, perasaan dan perilaku yang menandakan keunikan seseorang dalam berinteraksi dengan lingkungannya. Pendekatan yang digunakan untuk menggambarkan kepribadian yaitu mengenai lima traits kepribadian (big five personalty) diantaranya extraversion, agreeableness, conscientiousness, neuroticism, openness to experiences. Terdapat reaksi emosi yang berbeda-beda pada mahasiswa saat menjalankan kegiatan daring selama pandemi. Penelitian ini bertujuan untuk mengetahui gambaran pengaruh dari kepribadian Big Five Personality terhadap reaksi emosi pada mahasiswa saat kegiatan belajar daring. Metode yang digunakan dalam penelitian ini menggunakan pendekatan studi deskriptif. Melalui kuesioner Big Five Personality, wawancara dan observasi yang dilakukan pada 6 orang mahasiswa, menunjukkan hasil penelitian bahwa meskipun subjek terkategorikan pada kepribadian yang berbeda menurut Big Five Personality, reaksi emosi yang ditunjukkan pada saat belajar daring menampilkan reaksi emosi negatif seperti marah, bosan, kesal dan menangis. Hal ini dipengaruhi oleh factor-faktor seperti penilaian subjek terhadap situasi belajar daring, keterbatasan alat hingga signal dan kuota yang tidak memadai
ANALISIS STRATEGI PEMASARAN PRODUK SMARTPHONEVIVO DI TELEMARCO PADA INTERNATIONAL PLAZA PALEMBANG
Authors: Hendrayani Iin 
Published: September 2021

Research of marketing strategy of Vivo smartphone products has been done at Telemarco at the Palembang International Plaza (IP). The purpose of this study was to find out the marketing strategy of the Smartphone Vivo product at the Palembang International Plaza. This research is a type of descriptive research using the method of presenting qualitative data which is analyzed using the SWOT method by describing the object of research based on strengths, weaknesses, opportunities and threats. Data collection techniques are carried out by means of Library Research and Field Research through observation and interviews. The results obtained from this study are that there are three marketing strategies of Vivo Smartphone in Telemarco Company which have been implemented include product strategies that build brand image, pricing strategies include cash and credit purchases, promotional strategies in the form of advertisements in Television, Newspapers and Online media as well as promo brochures and gift giving. The marketing strategy that has been carried out by the Telemarco Company is basically in accordance with the results of the SWOT analysis conducted on Vivo Smartphone products which include elements of marketing mix strategies such as Produck, Price, Promotion, and Place. Suggestions that can be given by the author in this study, Vivo provides gifts to consumers and the ease of buying by installments or also giving discount prices to attract consumers to buy. Marketing strategy analysis needs to be done every year so that the company always gets a new alternative strategy that is more innovative so that the goal to reach market marketing leaders can be achieved.
Farmers’ Attitude towards Custom Hiring Centers: An Exploratory Study in Punjab
Authors: Kumar Kuldeep , Meena H. R. , Kadian K. S. , Meena B. S. , Bhandari Gunjan , Kaur Jasvinder 
Published: September 2021

Stubble burning is a major threat to environment in trans- gangetic plain region, where there exists bright prospect to reap the benefits of custom hiring centers by leveraging the suitable farm machinery helpful in overcoming the stubble burning issue. Present study was conducted in Punjab state and three districts namely, Ludhiana, Sangrur, Moga were selected purposively due to highest stubble burning cases in last five years. From each district two block were selected randomly. Subsequently, three villages from each block were randomly selected. Finally, from each village 20 respondents were selected randomly constituting of total 360 farmers. Two scales were constructed exclusively for the study in order to measure the attitude of farmers towards custom hiring centres (CHCs) and elicitation of perception regarding stubble burning. Results indicated that majority of the respondents had favorable attitude towards CHCs, followed by 22.78 per cent of respondents having neutral attitude towards CHCs and only 8.89 per cent of respondents has unfavorable attitude towards CHCs. CHCs were not sufficient in number to cater the high demand during the peak seasons. Those machines which are of least demand should be replaced by machines with high demand. Majority of the respondents agreed that crop residue burning has a negative effect on plant health, air, human health, animal health, biodiversity, vehicular traffic and soil health. It was found that less than half (47.23%) of the respondent had high level of perception.
Assured learning‐enabled autonomy: A metacognitive reinforcement learning framework
Authors: Mustafa Aquib , Mazouchi Majid , Nageshrao Subramanya , Modares Hamidreza 
Published: September 2021

SummaryReinforcement learning (RL) agents with pre‐specified reward functions cannot provide guaranteed safety across variety of circumstances that an uncertain system might encounter. To guarantee performance while assuring satisfaction of safety constraints across variety of circumstances, an assured autonomous control framework is presented in this article by empowering RL algorithms with metacognitive learning capabilities. More specifically, adapting the reward function parameters of the RL agent is performed in a metacognitive decision‐making layer to assure the feasibility of RL agent. That is, to assure that the learned policy by the RL agent satisfies safety constraints specified by signal temporal logic while achieving as much performance as possible. The metacognitive layer monitors any possible future safety violation under the actions of the RL agent and employs a higher‐layer Bayesian RL algorithm to proactively adapt the reward function for the lower‐layer RL agent. To minimize the higher‐layer Bayesian RL intervention, a fitness function is leveraged by the metacognitive layer as a metric to evaluate success of the lower‐layer RL agent in satisfaction of safety and liveness specifications, and the higher‐layer Bayesian RL intervenes only if there is a risk of lower‐layer RL failure. Finally, a simulation example is provided to validate the effectiveness of the proposed approach.