Outcomes of SARS-CoV-2 infected pregnancies after medically assisted reproduction
Authors:   The ESHRE COVID-19 Working Group, Rjeily Walid Abou , Alataş Cengiz , Alkon Tamal , Luna Martha , Balic Devleta , Barros Alberto , Beckers Nicole , Begum Rashida , Boeykens Frederico , Boleac Ioan , Bunescu Cosmina , Calhaz-Jorge Carlos , Colicchia Antonio , Dajti Irida , De Vreis Marjolein , Ribeiro Samuel Dos Santos , Dundovic Marija , Duran Victoria Antequera , Elhusien Mohamed Mamdouh , Esteves Sandro , Felgueira Eduarda , Goncikowska Ewa , Güell Enric , Gwet-Bell Ernestine , Heleno Lara , Guimarães Joana Mesquita , Ildiko Mitranovici Melinda , Karlikaya Guvenc , Kaul-Mahajan Nalini , Khahylenko Kseniia , Kovacs Peter , Krause Manja , Kumaran Aswathy , Lkshmi Manu , Nogueira Daniela , Cil Aylin Pelin , Pelvina Valeriia , Polisseni Fernanda , Popovici Roxana , Putra Mahadinata , Rageh Kamal Eldin , Raouf Nazdar , Edward Edo Rezaldy , Sertã Ricardo , Seyhan Ayse , Soares Sergio , Sonntag Barbara , Stastna Eva , Gurung Anupama Suwal , Vives Margarita Torres , Turgal Mert , Xavier Pedro , Ata Baris , Gianaroli Luca , Lundin Kersti , Mcheik Saria , Mocanu Edgar , Rautakallio-Hokkanen Satu , Tapanainen Juha S , Vermeulen Nathalie , Veiga Anna 
Published: September 2021

Abstract

STUDY QUESTION
What is the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the outcome of a pregnancy after medically assisted reproduction (MAR)?

SUMMARY ANSWER
Our results suggest that MAR pregnancies are not differentially affected by SARS-CoV-2 infection compared to spontaneous pregnancies.

WHAT IS KNOWN ALREADY
Information on the effects of coronavirus disease 2019 (COVID-19) on pregnancy after MAR is scarce when women get infected during MAR or early pregnancy, even though such information is vital for informing women seeking pregnancy.

STUDY DESIGN, SIZE, DURATION
Data from SARS-CoV-2 affected MAR pregnancies were collected between May 2020 and June 2021 through a voluntary data collection, organised by the European Society of Human Reproduction and Embryology (ESHRE).

PARTICIPANTS/MATERIALS, SETTING, METHODS
All ESHRE members were invited to participate to an online data collection for SARS-CoV-2-infected MAR pregnancies.

MAIN RESULTS AND THE ROLE OF CHANCE
The dataset includes 80 cases from 32 countries, including 67 live births, 10 miscarriages, 2 stillbirths and 1 maternal death. An additional 25pregnancies were ongoing at the time of writing.

LIMITATIONS, REASONS FOR CAUTION
An international data registry based on voluntary contribution can be subject to selective reporting with possible risks of over- or under-estimation.

WIDER IMPLICATIONS OF THE FINDINGS
The current data can be used to guide clinical decisions in the care of women pregnant after MAR, in the context of the COVID-19 pandemic.

STUDY FUNDING/COMPETING INTEREST(S)
The authors acknowledge the support of ESHRE for the data registry and meetings. J.S.T. reports grants or contracts from Sigrid Juselius Foundation, EU and Helsinki University Hospital Funds, outside the scope of the current work. The other authors declare that they have no conflict of interest.

TRIAL REGISTRATION NUMBER
N/A.