bluuebunny/crossref_metadata_2025_split huggingface dataset:
Last Interglacial sea-level proxies in the western Mediterranean
Authors: Cerrone Ciro , Vacchi Matteo , Fontana Alessandro , Rovere Alessio 
Published: September 2021

Abstract. We describe a database of Last Interglacial (Marine Isotopic Stage 5) sea-level proxies for the western Mediterranean region. The database was compiled reviewing the information reported in 199
published studies and contains 396 sea-level data points (sea-level index points and marine- or terrestrial-limiting points) and 401 associated dated samples. The database follows the standardized WALIS template and is
available as Cerrone et al. (2021b, https://doi.org/10.5281/zenodo.5341661).
LamaH-CE: LArge-SaMple DAta for Hydrology and Environmental Sciences for Central Europe
Authors: Klingler Christoph , Schulz Karsten , Herrnegger Mathew 
Published: September 2021

Abstract. Very large and comprehensive datasets are increasingly used in the field of
hydrology. Large-sample studies provide insights into the hydrological cycle
that might not be available with small-scale studies. LamaH-CE
(LArge-SaMple DAta for Hydrology and Environmental Sciences for Central Europe, LamaH for short; the geographical extension “-CE” is omitted in the text and the dataset) is a new
dataset for large-sample studies and comparative hydrology in Central
Europe. It covers the entire upper Danube to the state border of
Austria–Slovakia, as well as all other Austrian catchments including their
foreign upstream areas. LamaH covers an area of about 170 000 km2 in
nine countries, ranging from lowland regions characterized by a continental
climate to high alpine zones dominated by snow and ice. Consequently, a wide
diversity of properties is present in the individual catchments. We represent
this variability in 859 gauged catchments with over 60 catchment attributes,
covering topography, climatology, hydrology, land cover, vegetation, soil and
geological properties. LamaH further contains a collection of runoff time
series as well as meteorological time series. These time series are provided
with a daily and hourly resolution. All meteorological and the majority of
runoff time series cover a span of over 35 years, which enables long-term
analyses with a high temporal resolution. The runoff time series are
classified by over 20 attributes including information about human impacts and
indicators for data quality and completeness. The structure of LamaH is based
on the well-known CAMELS (Catchment Attributes and MEteorology for Large-sample Studies) datasets. In contrast, however, LamaH does not only
consider independent basins, covering the full upstream area. Intermediate
catchments are covered as well, which allows together with novel attributes the
considering of the hydrological network and river topology in applications. We
not only describe the basic datasets used and methodology of data preparation
but also focus on possible limitations and uncertainties. LamaH contains
additionally results of a conceptual hydrological baseline model for checking
plausibility of the inputs as well as benchmarking. Potential applications of
LamaH are outlined as well, since it is intended to serve as a uniform data
basis for further research. LamaH is available at https://doi.org/10.5281/zenodo.4525244
(Klingler et al., 2021).
Evaluation of the Most Common Dental Procedural Errors Leading to Lawsuits and the Relevant Reasons in Three Dental Clinics in Tehran
Authors: Yazdanian Mohsen , Rafiei Esmail , Rahmani Aghil , Tahmasebi Elahe , Hajiesfandiari Abbas 
Published: September 2021

One of the most important occupational stresses that dentists encounter in their profession is patients’ lawsuits. The present study aimed to evaluate common procedural errors that lead to lawsuits in dentistry. In the present cross-sectional study, all the patient files of three large dental clinics in Tehran were evaluated from 2014 to 2019, in which a dentist’s negligence had been confirmed by the specialty dental committee. Files with incomplete clinical data, without the dentist’s name, and the type of the lawsuit were excludeda and Finally, 107 lawsuit files were confirmed and entered the study. After extraction of the data from the existing files and completing the relevant checklist, data were analyzed with SPSS 23. Most lawsuits were of the therapeutic type (88 cases, 82%), with 34 cases (31.9%) , 26 cases (24.2%) and 19 cases (17.6%) related to prosthodontics, endodontics, and surgery, respectively. Most plaintiffs were 30–49 years of age (56 cases ,52%), and most were women (70 cases, 65%). Over half of the lawsuits had been filed against dentists with a job experience of <10 years and against general dental practitioners (81 cases, 76%). One of the most important ways to prevent errors leading to lawsuits is to increase dentists’ knowledge about previous lawsuits. Knowledge about the most common lawsuits and the provision of organizational guidelines will help manage and decrease such lawsuits.
DỊCH TỄ, CHẨN ĐOÁN, ĐIỀU TRỊ COVID-19 TRẺ EM
Authors: Khanh Nguyễn Công 
Published: September 2021

Bệnh coronavirus 2019 (COVID-19) là bệnh nhiễm khuẩn hô hấp do virus corona mới SARS-CoV-2. Sau khi bệnh bùng phát đầu tiên ở Trung Quốc, bệnh lan rộng ra nhiều nước trên thế giới,
kể cả Việt Nam. COVID-19 là bệnh nhiễm khuẩn mới nổi lên, gây nhiều thách thức lớn về kiểmsoát, chẩn đoán, chăm sóc, điều trị, nhất là trẻ em. Bài tổng quan này nhằm tổng hợp một sốvấn đề về dịch tễ, chẩn đoán và điều trị COVID-19 trẻ em qua y văn, các hướng dẫn, đồng thuậncủa một số tổ chức quốc tế. Bệnh xảy ra ở mọi lứa tuổi, kể cả trẻ sơ sinh, và chỉ chiếm khoảng2% tổng số người mắc COVID-19. Phần lớn trẻ mắc COVID-19 không có triệu chứng và là thểnhẹ đến vừa, chỉ 2% cần phải hồi sức tích cực, tử vong rất thấp, điều này còn chưa có giải thíchđầy đủ. Nghi ngờ mắc COVID-19 khi có triệu chứng hô hấp với một yếu tố dịch tễ. Trẻ sơ sinh,nghi nhiễm bệnh khi sinh từ mẹ nhiễm COVID-19 trong 14 ngày trước sinh hay 28 ngày sau sinh.Chẩn đoán xác định khi xét nghiệm PCR dịch hô hấp SARS-CoV-2 dương tính. Điều trị COVID-19trẻ em, chủ yếu là cách ly dự phòng lây truyền sang người khác, điều trị hỗ trợ là chính. Điều trịđặc hiệu phải được cân nhắc, dựa vào tình trạng nặng của bệnh, tuổi, và các yếu tố nguy cơ.
NHIỄM TOAN CHUYỂN HÓA THEO KHOẢNG TRỐNG ANION
Authors: Thắng Phạm Văn , Mạnh Nguyễn Tiến 
Published: September 2021

Nhiễm toan chuyển hóa được định nghĩa là một quá trình bệnh lý, làm tăng nồng độ của các ion hydro trong cơ thể và làm giảm nồng độ HCO3 -. Toan chuyển hóa được chẩn đoán khi pH động mạch thấp (<7,35), HCO3- thấp (<18mmol/l), pCO2thấp (<35 mmHg) và BE giảm. Kèm theo có /hoặc không các triệu chứng lâm sàng như thở nhanh sâu, nhịp thở Kussmaul, rối loạn thần kinh bao gồm nhức đầu, buồn nôn, lơ mơ, hôn mê và cuối cùng là trụy mạch [5,6].
Theo A. Durward và CS có đến 46% số trẻ em nhập khoa ICU bị toan chuyển hóa [1]. Một nghiên cứu khác của NaPa và CS thì số trẻ em bị toan chuyển hóa là 27% [1]. Theo Phí Đức Long và P.V.Thắng, tỷ lệ nhiễm toan chuyển hóa chiếm 51% tổng số trẻ nhiễm toan tại PICU [3].
Có nhiều nguyên nhân dẫn đến toan chuyển hóa với các biểu hiện lâm sàng khác nhau. Nhiễm toan nặng có thể gây nhiều biến chứng và dẫn đến tử vong nhanh chóng. Toan chuyển hóa ảnh hưởng lên rất nhiều cơ quan trong đó tim mạch là hệ cơ quan bị ảnh hưởng nặng nề nhất. Sức co bóp cơ tim và thể tích nhát bóp giảm, các chất giãn mạch được giải phóng gây hạ huyết áp. Sựsuy giảm chức năng cơ tim xảy ra phụ thuộc vào pH. Khi pH giảm từ 7,4 xuống 7,2 thể tích nhát bóp có thể tăng do các catecholamine được giải phóng, nhưng khi pH giảm xuống dưới 7,2 thì sự suy giảm thể tích nhát bóp chắc chắn sẽ xảyra. Ngoài ra sự kháng các thuốc vận mạch cũng như các rối loạn nhịp thất cũng được ghi nhận ở những bệnh nhân toan chuyển hóa nặng [16].
Sự suy giảm ý thức, hôn mê cũng thấy ở những bệnh nhân toan chuyển hóa nặng mặc dù pH dịch não tủy chỉ thay đổi nhỏ. Toan chuyển hóa còn làm ảnh hưởng đến ái lực của gắn của oxy vào phân tử hemoglobin. Thời gian toan càng kéo dài, ái lực gắn càng giảm. Ngoài ra, trong toan chuyển hóa cấp tính, hoạt động của các tế bào lympho cũng như khả năng diệt khuẩn của bạch cầu bị suy giảm dẫn tới bệnh nhân dễ bị nhiễm trùng hơn. Ở những bệnh nhân này, toan chuyển hóa còn gây ra giảm hoạt động sản xuất ATP do ức chế 6-phosphofructokinase và thúc đẩy sự chết theo chương trình của tế bào [16]. Do những tác động xấu lên cơ thể nên những bệnh nhân toan chuyển hóa nếu không được điều trị kịp thời sẽ có tiên lượng rất xấu. Tiênlượng càng xấu khi mức độ toan càng nặng.
Legal Remedies against State Funding Decisions in Slovakia
Authors: Hulkó Gábor 
Published: September 2021

Legal remedies against decisions of central state administration or special administrative bodies instead of the standardly used appeal (which is more or less identical in all Visegrad states) special types of legal remedies step in, which can be still considered as ordinary remedies. In Slovakia, the standard legal remedy in administrative procedures is the appeal (in case of organs of central administration called remonstrance) regulated by Act no. 71/1976 on Administrative Proceedings, however in case of special organs this regulation is often overwritten by special rules and by special legal remedies. Latter mentioned – from a jurisprudential point of view - raising the question, whether they can really serve as a tool for a real legal remedy if they represent an effective tool of decision supervision. The following case study introduces the standard procedure of use of such special legal remedy against a decision of the State Fund for Housing Development in Slovakia.
Evidence from the resurrected family Polyrhabdinidae Kamm, 1922 (Apicomplexa: Gregarinomorpha) supports the epimerite, an attachment organelle, as a major eugregarine innovation
Authors: Paskerova Gita G. , Miroliubova Tatiana S. , Valigurová Andrea , Janouškovec Jan , Kováčiková Magdaléna , Diakin Andrei , Sokolova Yuliya Ya. , Mikhailov Kirill V. , Aleoshin Vladimir V. , Simdyanov Timur G. 
Published: September 2021

Background
Gregarines are a major group of apicomplexan parasites of invertebrates. The gregarine classification is largely incomplete because it relies primarily on light microscopy, while electron microscopy and molecular data in the group are fragmentary and often do not overlap. A key characteristic in gregarine taxonomy is the structure and function of their attachment organelles (AOs). AOs have been commonly classified as “mucrons” or “epimerites” based on their association with other cellular traits such as septation. An alternative proposal focused on the AOs structure, functional role, and developmental fate has recently restricted the terms “mucron” to archigregarines and “epimerite” to eugregarines.

Methods
Light microscopy and scanning and transmission electron microscopy, molecular phylogenetic analyses of ribosomal RNA genes.

Results
We obtained the first data on fine morphology of aseptate eugregarines Polyrhabdina pygospionis and Polyrhabdina cf. spionis, the type species. We demonstrate that their AOs differ from the mucron in archigregarines and represent an epimerite structurally resembling that in other eugregarines examined using electron microscopy. We then used the concatenated ribosomal operon DNA sequences (SSU, 5.8S, and LSU rDNA) of P. pygospionis to explore the phylogeny of eugregarines with a resolution superior to SSU rDNA alone. The obtained phylogenies show that the Polyrhabdina clade represents an independent, deep-branching family in the Ancoroidea clade within eugregarines. Combined, these results lend strong support to the hypothesis that the epimerite is a synapomorphic innovation of eugregarines. Based on these findings, we resurrect the family Polyrhabdinidae Kamm, 1922 and erect and diagnose the family Trollidiidae fam. n. within the superfamily Ancoroidea Simdyanov et al., 2017. Additionally, we re-describe the characteristics of P. pygospionis, emend the diagnoses of the genus Polyrhabdina, the family Polyrhabdinidae, and the superfamily Ancoroidea.
miR-1293 acts as a tumor promotor in lung adenocarcinoma via targeting phosphoglucomutase 5
Authors: Chen Bing , Zheng Shiya , Jiang Feng 
Published: September 2021

Background
Lung adenocarcinoma (LUAD) is the most common histologic subtype of lung cancer. Studies have found that miR-1293 is related to the survival of LUAD patients. Unfortunately, its role in LUAD remains not fully clarified.

Methods
miR-1293 expression and its association with LUAD patients’ clinical characteristics were analyzed in TCGA database. Also, miR-1293 expression was detected in LUAD cell lines. Cell viability, migration, invasion and expression of MMP2 and MMP9 were measured in LUAD cells following transfection with miR-1293 mimic or antagomir. Phosphoglucomutase (PGM) 5 was identified to be negatively related to miR-1293 in LUAD patients in TCGA database, and their association was predicated by Targetscan software. Hence, we further verified the relationship between miR-1293 and PGM5. Additionally, the effect and mechanism of miR-1293 were validated in a xenograft mouse model.

Results
We found miR-1293 expression was elevated, but PGM5 was decreased, in LUAD patients and cell lines. Higher miR-1293 expression was positively related to LUAD patients’ pathologic stage and poor overall survival. miR-1293 mimic significantly promoted, whereas miR-1293 antagomir suppressed the viability, migration, invasion, and expression of MMP2 and MMP9 in LUAD cells. PGM5 was a target of miR-1293. Overexpression of PGM5 abrogated the effects of miR-1293 on the malignant phenotypes of LUAD cells. Administration of miR-1293 antagomir reduced tumor volume and staining of Ki-67 and MMP9, but elevated PGM5 expression in vivo.

Conclusions
miR-1293 promoted the proliferation, migration and invasion of LUAD cells via targeting PGM5, which indicated that miR-1293 might serve as a potential therapeutic target for LUAD patients.
Antioxidants, inhibits the growth of foodborne pathogens and reduces nitric oxide activity in LPS-stimulated RAW 264.7 cells of nipa palm vinegar
Authors: Senghoi Wilaiwan , Klangbud Wiyada Kwanhian 
Published: September 2021

Nipa palm vinegar (NPV) made from the sap of nipa palm (Nypa fruticansWurmb.) has long been used as a local food seasoning and folk medicine. This study compared the bioactive compounds, antioxidant,in vitroanti-inflammatory and antimicrobial activities of three NPVs obtained from different plantations based on varied soil and water salinity levels, including fresh water NPV, brackish water NPV and saline water NPV. The analysis results revealed that total phenolic content of saline water NPV had statistically significantly lower than both fresh water and brackish water NPV (p < 0.0001). Furthermore percentage of acetic acid in brackish water NPV had statistically significantly lower than both fresh water and saline water. NPV (p = 0.002). Nevertheless, total flavonoid and pH, were not significantly different (p = 0.144 and 0.066, respectively). The antioxidant activities using three ABTS, DPPH and FRAP methods displayed similar patterns, in which saline water NPV showed the highest antioxidant activities, followed by brackish water and fresh water NPV, respectively. Antimicrobial activity was examined for seven enteropathogenic bacteria. The tested NPVs were found inhibitive against all test cultures with a minimum inhibitory concentration (MIC) of ≤ 7.8 µL/mL. The cytotoxicity of the NPV obtained from different plantations by MTT assay revealed low cytotoxicity. Anti-inflammatory activity was also carried out through the inhibition of nitric oxide production. The fresh water NPV exhibited the highest anti-inflammatory activity with IC50 17.59 ± 0.17 µL/mL, followed by saline and brackish water NPV with IC50 18.12 ± 0.49 and 28.29 ± 2.64 µL/mL, respectively. The findings indicated that NPV from different soil salinities could potentially be natural functional food and developed to antimicrobial and anti-inflammatory medicinal agents with safety.
Spinal curvatures of yoga practitioners compared to control participants—a cross-sectional study
Authors: Grabara Małgorzata 
Published: September 2021

Purpose
The angles of thoracic kyphosis and lumbar lordosis determine the spinal alignment in the sagittal plane. The aim of this study was to compare the thoracic kyphosis and lumbar lordosis of male and female yoga practitioners with non-practicing participants and to determine the possible dependencies between sagittal spinal curvatures and somatic parameters, time spent on yoga exercise, and undertaking other physical activities in yoga practitioners.

Methods
The study involved 576 women and 91 men ages 18–68 years (mean = 38.5 ± 9) who were practicing yoga, and 402 women and 176 men ages 18–30 years (mean = 20.2 ± 1.3) as a control group. The angles of thoracic kyphosis and lumbar lordosis were measured using a Plurimeter-V gravity inclinometer.

Results
The two-way ANOVA demonstrated the influence of group (p < .0001) and sex (p = .03) on the angle of thoracic kyphosis, as well as the influence of group (p < .0001) and sex (p < .0001) on the angle of lumbar lordosis. It was noted that yoga practitioners had less pronounced thoracic kyphosis and lumbar lordosis and were more often characterized by normal or smaller thoracic kyphosis and lumbar lordosis than students from the control group. In yoga practitioners, the angle of thoracic kyphosis was positively correlated with age, body mass, BMI, and undertaking other forms of physical activity. The angle of lumbar lordosis was negatively correlated with body height and body mass.

Conclusions
The results suggest that yoga exercises can affect the shape of the anterior-posterior curves of the spine and may be an efficient training method for shaping proper posture in adults.
Self-Directed Learning, Self-Efficacy in Learning, and Academic Motivation of Public Senior High School Students
Authors: Coros Joenel D. , Madrigal Dennis V. 
Published: September 2021

Aims: The absence of data complementing independent learning, which is vital in the pandemic-induced distance learning, propelled the conduct of study. The study aimed to assess Self-Directed Learning, Self-Efficacy in Learning, and Academic Motivation of Public Senior High School Students, and investigated what demographic variable may influence each. It also sought to determine the correlation between the constructs.
Methodology: The study utilized descriptive and correlational design. Respondents were the 332 Grade-12 students from the Schools Division of Cadiz City, School Year 2020-2021, determined using multi-stage random sampling. Data were generated using the Self-Directed Learning Inventory, Self-Efficacy in Learning Form, and Academic Motivation Scale – High School Version. Data were analyzed using mean, standard deviation, chi-square test of association, and Spearman rho rank correlation.
Results: There was no significant relationship between demographics and Self-Directed Learning, likewise with Academic Motivation. There was no significant relationship between sex and Self-Efficacy in Learning, however the latter had a significant relationship with family income (P=.05) and track (P=.03). There was a significant relationship between self-directed learning and self-efficacy in learning (P=.000), and between self-directed learning and academic motivation (P=.000).
Conclusion: Student demographics do not influence their disposition to engage in learning activities and with their perceived reasons to participate in it. Family income, together with the track where they belong, may influence their belief in their innate capabilities. Students who are internally driven to learn, and who have strong belief in their capabilities, will find all means to master competence on academics, even without the help of other people.
Appraisal on Microbiologal Qualities of Hospital Wastewaters from off a Local Government Area of Kwara State, Nigeria
Authors: Muftau Usman Kolawole , Juwon Arotupin Daniel , Olanipekun Ekundayo, Fatuyi 
Published: September 2021

Aims: This study investigates the microorganisms associated with hospital wastewaters collected from the Offa Local Government Area of Kwara State, Nigeria, during the wet and dry seasons.
Study Design: This project was a cross sectional descriptive study in which subjects were hospital wastewater samples collected from the study site.
Place and Duration of Study: the samples were analyzed in the department of microbiology, Federal University of Technology, Akure, Ondo State, Nigeria.
Methodology: Microbiological study of one hundred and twenty-six samples of hospital wastewater collected both during wet season and dry season periods in the years 2018 – 2019 from Offa Local Government Area of Kwara State, Nigeria, was carried out using conventional and molecular techniques respectively and the Global Positioning System (GPS) of each collection site was accurately recorded.
Results: The microbial load of wet season samples collected from Offa Local Government Area ranged between 7±4,00 and 150±43.59 while that of dry season samples ranged between 10±2.00 x 105 and 225±67.27 (x 105cfu/ml). The bacteria isolated from wet season samples included; Alcaligenes faecalis, A. aquatilis and Staphylococcus saprophyticus with percentage occurrences of 65.4, 19.2 and 15.4 respectively, while bacteria isolated from dry season sample were A. faecalis and S. saprophyticus with percentages occurrence of 79.17 and 20.89, respectively.
Conclusion: The findings from this study showed that hospital wastewater collected during dry season period had more bacterial load than that of wet season period. The findings also confirmed A. faecalis as the most predominant and prevailing bacteria inhabiting hospital wastewater. Thus, care must be taken by avoiding hospital wastewater from getting into the municipal water supply to prevent infections associated with A. faecalis, A. aquatilis and S. saprophyticus.
Ashwagandha-Induced Gastric Upset in Post-Covid Patient-A Case Report and Brief Review of the Literature
Authors: Javed Danish , Najmi Ahmad 
Published: September 2021

Adverse drug reporting of herbal drugs is less common as they are generally considered as safe. It is also very common to use self-medication by people in the case of herbal drugs. But many times, mild to severe events have been seen with the use of herbal or ayurvedic medicines. We have reported a case of post-covid patient, who was having complained of headache, body ache, lethargy, backache, generalized weakness and excessive sweating since one weak. Patient had past history of hospitalization due to COVID-19 moderate pneumonia one month back. Patient also had history of type-2 diabetes mellitus, hypertension and dyslipidemia and was taking anti-diabetic and anti-hypertensive medications continuously. Ashwagandha powder (Withania somnifera), Maha yogaraj guggulu (herbal anti-inflammatory) and Syrup Amynity Plus (herbal immune-booster) were prescribed for these complain. Conversely, moderate severity adverse reaction like nausea, vomiting, diarrhea, and abdominal cramps were noted after the intake of suspected drug i.e. ashwagandha powder. Nevertheless, symptoms were relieved after the de-challenge. This shows a temporal relation of the event with the suspected drug. One more possibility of drug-drug interaction in this case cannot be ruled out completely. Causality assessment was done for this adverse event and it was considered as the “probable” category of the adverse event in WHO causality classification.