bluuebunny/crossref_metadata_2025_split huggingface dataset:
Noncanonical NF-κB Signaling Upregulation in Inflammatory Bowel Disease Patients is Associated With Loss of Response to Anti-TNF Agents
Authors: Nguyen Vu Q. , Eden Kristin , Morrison Holly A. , Sammons Megan B. , Knight Kristin K. , Sorrentino Siena , Brock Rebecca M. , Grider Douglas J. , Allen Irving C. , Sorrentino Dario 
Published: June 2021

Objectives: Targeting tumor necrosis factor (TNF) with biologic agents, such as infliximab and adalimumab, is a widely used and effective therapeutic strategy in inflammatory bowel disease (IBD). Unfortunately, a significant number of patients fail to respond or lose response over time to these agents. Previous studies have defined multiple complex roles for canonical NF-κB signaling in the pathogenesis of IBD. However, preliminary evidence suggests that the lesser defined noncanonical NF-κB signaling pathway also contributes to disease pathogenesis and response to anti-TNF agents. The objective of this study was to evaluate this hypothesis in Crohn’s disease (CD) and ulcerative colitis (UC) patients.Design: A total of 27 subjects with IBD (19 with CD and 8 with UC) and 15 control subjects were tested. Clinical criteria, patient history, and endoscopic disease activity were factors used to categorize patients and define therapeutic response. Biopsy specimens were collected during colonoscopy and expression was determined for 88 target genes known to be associated with noncanonical NF-κB signaling and IBD.Results: Noncanonical NF-κB signaling was significantly upregulated in IBD patients and was associated with increased gastrointestinal inflammation, epithelial cell death, lymphocyte migration, and Nod-like receptor signaling. Furthermore, noncanonical NF-κB signaling was further upregulated in patients unresponsive to anti-TNF agents and was suppressed in responsive patients. MAP3K14, NFKB2, CCL19, CXCL12, and CXCL13 were significantly dysregulated, as were genes that encode pathway regulators, such as CYLD, NLRP12, and BIRC2/3.Conclusion: Our study identifies a previously uncharacterized role for the understudied noncanonical NF-κB signaling pathway in the pathogenesis of IBD and anti-TNF therapy responsiveness. The genes and pathways identified may ultimately prove useful in IBD management and could potentially be used as biomarkers of drug response.
Chinese Herbal Medicine for the Treatment of Children and Adolescents With Refractory Mycoplasma Pneumoniae Pneumonia: A Systematic Review and a Meta-Analysis
Authors: Ling Xiaoying , Sun Xun , Kong Huimin , Peng Shanshan , Yu Zheng , Wen Jiali , Yuan Bin 
Published: June 2021

Objectives: Chinese herb medicine (CHM) is one of the most popular complementary and alternative therapies, which has been widely used to treat Refractory Mycoplasma Pneumoniae Pneumonia (RMPP). However, the effect and safety of CHM remain controversial. Hence, we conducted this meta-analysis to evaluate whether CHM combination therapy could bring benefits to children and adolescents with RMPP.Methods: Seven databases were used for data searching through November 11, 2020 following the PRISMA checklist generally. Review Manager 5.3, Trial sequential analysis 0.9.5.10 Beta software and Stata16.0 were applied to perform data analyses. Mean difference or risk ratio was adopted to express the results, where a 95% confidence interval (CI) was applied.Results: In general, this research enrolled 17 trials with 1,451 participants. The overall pooled results indicated that CHM was beneficial for children and adolescents with RMPP by improving the clinical efficacy rate [RR = 1.20, 95% CI (1.15, 1.25), p &lt; 0.00001], shortening antipyretic time [MD = −2.60, 95% CI (−3.06, −2.13), p &lt; 0.00001], cough disappearance time [MD = −2.77, 95% CI (−3.12, −2.42), p &lt; 0.00001], lung rale disappearance time [MD = −2.65, 95% CI (−3.15, −2.15), p &lt; 0.00001], lung X-ray infiltrates disappearance time [MD = −2.75, 95% CI (−3.33, −2.17), p &lt; 0.00001], reducing TNF-α level [MD = −5.49, 95% CI (−7.21, −3.77), p &lt; 0.00001]. Moreover, subgroup results suggested that removing heat-phlegm and toxicity therapy had more advantages in shortening antipyretic time, cough disappearance time, lung X-ray infiltrates disappearance time and reducing TNF-α level. Meanwhile promoting blood circulation therapy seemed to be better at relieving lung rale. However, regarding adverse events, the two groups displayed no statistical difference [RR = 0.97, 95% CI (0.60, 1.57), p = 0.91].Conclusion: Despite of the apparently positive results in relieving clinical symptoms, physical signs and reducing inflammation, it is premature to confirm the efficacy of CHM in treating RMPP because of the limitation of quality and the number of the included studies. More large-scale, double-blind, well-designed, randomized controlled trials are needed in future research.
Case Report: Chronic Bacterial Prostatitis Treated With Phage Therapy After Multiple Failed Antibiotic Treatments
Authors: Johri Apurva Virmani , Johri Pranav , Hoyle Naomi , Pipia Levan , Nadareishvili Lia , Nizharadze Dea 
Published: June 2021

Background: Chronic Bacterial Prostatitis (CBP) is an inflammatory condition caused by a persistent bacterial infection of the prostate gland and its surrounding areas in the male pelvic region. It is most common in men under 50 years of age. It is a long-lasting and debilitating condition that severely deteriorates the patient’s quality of life. Anatomical limitations and antimicrobial resistance limit the effectiveness of antibiotic treatment of CBP. Bacteriophage therapy is proposed as a promising alternative treatment of CBP and related infections. Bacteriophage therapy is the use of lytic bacterial viruses to treat bacterial infections. Many cases of CBP are complicated by infections caused by both nosocomial and community acquired multidrug resistant bacteria. Frequently encountered strains include Vancomycin resistant Enterococci, Extended Spectrum Beta Lactam resistant Escherichia coli, other gram-positive organisms such as Staphylococcus and Streptococcus, Enterobacteriaceae such as Klebsiella and Proteus, and Pseudomonas aeruginosa, among others.Case Presentation: We present a patient with the typical manifestations of CBP. The patient underwent multiple courses of antibiotic treatment without any long-term resolution of his symptoms. Testing of prostatic secretion and semen samples revealed pathogenic bacteria in each case, which collectively included members of the Staphylococcal species such as Methicillin resistant Staphylococcus aureus (MRSA) and Staphylococcus haemolyticus, Enterococcus faecalis, and Streptococcus mitis, among others.Methods and Outcome: Bacteriophage preparations from the Eliava Institute were used to treat the patient after establishing phage sensitivity to the pathogenic bacteria. Significant improvements in symptoms and re-testing of samples after bacteriophage treatment indicated a reduction in the bacterial load and resolution of the infection.Discussion: The patient saw significant improvement of symptoms, and positive dynamics in bacterial titers and ultrasound controls after phage therapy. The failure of antibiotic therapy and subsequent success of bacteriophage therapy in treating chronic bacterial prostatitis shows the effectiveness of bacteriophages in controlling chronic infections in areas of low vascularity and anatomical complexity. These cases also highlight the efficacy of phages in overcoming antibiotic-resistant infections as well as biofilm infections.
The State of Music Therapy Studies in the Past 20 Years: A Bibliometric Analysis
Authors: Li Kailimi , Weng Linman , Wang Xueqiang 
Published: June 2021

Purpose: Music therapy is increasingly being used to address physical, emotional, cognitive, and social needs of individuals. However, publications on the global trends of music therapy using bibliometric analysis are rare. The study aimed to use the CiteSpace software to provide global scientific research about music therapy from 2000 to 2019.Methods: Publications between 2000 and 2019 related to music therapy were searched from the Web of Science (WoS) database. The CiteSpace V software was used to perform co-citation analysis about authors, and visualize the collaborations between countries or regions into a network map. Linear regression was applied to analyze the overall publication trend.Results: In this study, a total of 1,004 studies met the inclusion criteria. These works were written by 2,531 authors from 1,219 institutions. The results revealed that music therapy publications had significant growth over time because the linear regression results revealed that the percentages had a notable increase from 2000 to 2019 (t = 14.621, P &lt; 0.001). The United States had the largest number of published studies (362 publications), along with the following outputs: citations on WoS (5,752), citations per study (15.89), and a high H-index value (37). The three keywords “efficacy,” “health,” and “older adults,” emphasized the research trends in terms of the strongest citation bursts.Conclusions: The overall trend in music therapy is positive. The findings provide useful information for music therapy researchers to identify new directions related to collaborators, popular issues, and research frontiers. The development prospects of music therapy could be expected, and future scholars could pay attention to the clinical significance of music therapy to improve the quality of life of people.
Relationships Between Sleep Problems and Stress Coping Strategies Adopted by Nurses Including Socio-Occupational Factors
Authors: Kowalczuk Krystyna , Krajewska-Kułak Elżbieta , Sobolewski Marek 
Published: June 2021

Introduction: The health of nurses has a direct impact on the quality of care and health outcomes for patients. The length and quality of sleep as well as the intensity of perceived stress have an impact on the health of nurses. An appropriate stress coping strategy can reduce the impact of stress and mitigate its negative consequences.Aim: The purpose of this study was to investigate relationships between excessive sleepiness and insomnia in interaction with selected socio-occupational factors and stress coping strategies among nurses.Material and Method: The cross-sectional study was conducted among 448 nurses working in hospitals in Podlasie Province in Poland. Mini-Cope inventory - the polish adaptation of Carver's BriefCope was used for measuring coping with stress. Sleep problems were assessed using the Athens Insomnia Scale and the Epworth Sleepiness Scale.Results: The most frequent used coping strategies were active strategies (active coping, planning). The least-used were avoidant strategies (behavioral disengagement, substance use). Excessive sleepiness affected 38% of surveyed, while insomnia 33%. Excessive sleepiness was most strongly related with behavioural disengagement (R2 = 18.6%), substance use (R2 = 17.5%), humour (R2 = 13.8%) and denial (R2 = 12.0%) while insomnia with substance use (R2 = 17.5%) and self-blame (R2 = 15.9%). Nurses with tertiary education experiencing sleep problems less frequently used the strategy of humour, behavioural disengagement, substance use and religion than with lower education. Nurses working in interventional wards experiencing excessive sleepiness used the strategy of humour, religion and positive reframing less often than those working in other wards while those suffering from insomnia used the strategy of humour more often than those working in other wards.Conclusions: The implementation of avoidant and support-seeking and emotion-oriented stress coping strategies by nurses were associated with the sleep problems. Tertiary education discourages nurses with sleep problems from using avoidant coping strategies and devoting themselves to religion. Education and improvement of the quality of sleep may prevent nurses from resorting to stress coping strategies that have a detrimental effect on their health and well-being.
International Expert Opinions and Recommendations on the Use of Melatonin in the Treatment of Insomnia and Circadian Sleep Disturbances in Adult Neuropsychiatric Disorders
Authors: Palagini Laura , Manni Raffaele , Aguglia Eugenio , Amore Mario , Brugnoli Roberto , Bioulac Stéphanie , Bourgin Patrice , Micoulaud Franchi Jean-Arthur , Girardi Paolo , Grassi Luigi , Lopez Régis , Mencacci Claudio , Plazzi Giuseppe , Maruani Julia , Minervino Antonino , Philip Pierre , Royant Parola Sylvie , Poirot Isabelle , Nobili Lino , Biggio Giovanni , Schroder Carmen M. , Geoffroy Pierre A. 
Published: June 2021

Introduction: Insomnia and circadian rhythm disorders, such as the delayed sleep phase syndrome, are frequent in psychiatric disorders and their evaluation and management in early stages should be a priority. The aim of this paper was to express recommendations on the use of exogenous melatonin, which exhibits both chronobiotic and sleep-promoting actions, for the treatment of these sleep disturbances in psychiatric disorders.Methods: To this aim, we conducted a systematic review according to PRISMA on the use of melatonin for the treatment of insomnia and circadian sleep disorders in neuropsychiatry. We expressed recommendations for the use of melatonin in psychiatric clinical practice for each disorder using the RAND/UCLA appropriateness method.Results: We selected 41 studies, which included mood disorders, schizophrenia, substance use disorders, attention deficit hyperactivity disorders, autism spectrum disorders, neurocognitive disorders, and delirium; no studies were found for both anxiety and eating disorders.Conclusion: The administration of prolonged release melatonin at 2–10 mg, 1–2 h before bedtime, might be used in the treatment of insomnia symptoms or comorbid insomnia in mood disorders, schizophrenia, in adults with autism spectrum disorders, neurocognitive disorders and during sedative-hypnotics discontinuation. Immediate release melatonin at &lt;1 mg might be useful in the treatment of circadian sleep disturbances of neuropsychiatric disorders.
Finding the Right Balance: A Social Norms Intervention to Reduce Heavy Drinking in University Students
Authors: Wolter Christine , Lesener Tino , Thomas Tobias Alexander , Hentschel Alicia-Carolin , Gusy Burkhard 
Published: June 2021

Introduction: Heavy alcohol consumption constitutes a major health risk among University students. Social relationships with peers strongly affect University students' perception of the drinking behavior of others, which in turn plays a crucial role in determining their own alcohol intake. University students tend to overestimate their peers' alcohol consumption – a belief that is associated with an increase in an individual's own consumption. Therefore, we implemented a social norms intervention with personalized normative feedback at a major University in Germany to reduce and prevent excessive drinking among University students.Methods: Our intervention was part of a regular health monitoring survey. We invited all enrolled University students to take part in this survey on two occasions. A total of 862 University students completed the questionnaire, 563 (65.3%) of which received e-mail-based feedback upon request concerning their peers' and their own alcohol consumption. For the intervention group (n = 190) as well as the control group (no feedback requested; n = 101), we included only University students in the evaluation who overestimated their peers' alcohol use and indicated above average consumption of the peers. We applied analyses of variance to assess intervention effects with regard to the correction of overestimated group norms as well as University students' drinking behavior.Results: Within the intervention group, we observed a significantly larger reduction of the previously overestimated behavioral norms compared to the control group (p &lt; 0.001; ηp2 = 0.06). With regard to behavioral outcomes the intervention group showed a significantly larger reduction in the AUDIT-C score (p = 0.020; ηp2 = 0.03).Discussion: Our study confirms previous research whereupon personalized, gender-specific and selective normative feedback is effective for alcohol prevention among University students. However, University students still overestimated their peers' alcohol intake after the intervention. Furthermore, we did not reach high-risk groups (University students with the highest alcohol intake) since no feedback was requested. Future studies should address factors influencing the impact of the intervention and reachability of selective groups.
Bicarbonate Evokes Reciprocal Changes in Intracellular Cyclic di-GMP and Cyclic AMP Levels in Pseudomonas aeruginosa
Authors: Ruksakiet Kasidid , Stercz Balázs , Tóth Gergő , Jaikumpun Pongsiri , Gróf Ilona , Tengölics Roland , Lohinai Zsolt M. , Horváth Péter , Deli Mária A. , Steward Martin C. , Dobay Orsolya , Zsembery Ákos 
Published: June 2021

The formation of Pseudomonas aeruginosa biofilms in cystic fibrosis (CF) is one of the most common causes of morbidity and mortality in CF patients. Cyclic di-GMP and cyclic AMP are second messengers regulating the bacterial lifestyle transition in response to environmental signals. We aimed to investigate the effects of extracellular pH and bicarbonate on intracellular c-di-GMP and cAMP levels, and on biofilm formation. P. aeruginosa was inoculated in a brain–heart infusion medium supplemented with 25 and 50 mM NaCl in ambient air (pH adjusted to 7.4 and 7.7 respectively), or with 25 and 50 mM NaHCO3 in 5% CO2 (pH 7.4 and 7.7). After 16 h incubation, c-di-GMP and cAMP were extracted and their concentrations determined. Biofilm formation was investigated using an xCelligence real-time cell analyzer and by crystal violet assay. Our results show that HCO3− exposure decreased c-di-GMP and increased cAMP levels in a dose-dependent manner. Biofilm formation was also reduced after 48 h exposure to HCO3−. The reciprocal changes in second messenger concentrations were not influenced by changes in medium pH or osmolality. These findings indicate that HCO3− per se modulates the levels of c-di-GMP and cAMP, thereby inhibiting biofilm formation and promoting the planktonic lifestyle of the bacteria.
Late 19th Century Jātaka Murals at the Buddhist Monastery in Batuvantudava, Sri Lanka
Authors: Koch Rolf Heinrich 
Published: June 2021

Cet article présente un ensemble de peintures murales du XIXe siècle parant au Sri Lanka le temple (« maison de l’image ») du monastère bouddhique de Batuvantudava, soit un sanctuaire principal où trône un Buddha assis et deux sanctuaires dédiés aux dieux bouddhistes. Les murs intérieurs du temple sont ornés de sept des histoires des vies antérieures (Jātaka) du Buddha Gautama. La présentation de ces peintures murales, ici explicitées à l’aune des sources singhalaises, constitue le cœur de cet article.
CORRELATION BETWEEN BODY FAT PERCENTAGE AND TOTAL CHOLESTEROL LEVELS TO HYPERTENSIVE ELDERLY WOMAN IN MADIUN
Authors: Widhi Binar Wahyuning , Putri Mega Arianti 
Published: June 2021

Background: Patients with hypertension have twice as great exposed to heart disease and eight times as large as a stroke risk than who do not experience hypertension. Risk increase in blood pressure on the person who has overweight than people with normal weight. Women who have increased cholesterol levels in the blood more vulnerable for hypertension (Nikolov et al., 2015).
Objectives: The purpose of this research aimed to determine a percentage of body fat and cholesterol levels of the elderly women in Posyandu, Geger Subdistrict, Madiun who occurrence of hypertension.
Methods: This research using cross sectional design. The sample using purposive sampling technique with 38 respondent which satisfy the inclusion criteria. Instrument used is Bioelectrical Impedance Analysis tool. Statistical test used is spearman rho with a significance level of α < 0.05.
Results: The results of this study showed that significant relationship between body fat percentage and blood pressure (p-value = .033; r = .304). Meanwhile, total cholesterol level did not show any relationship with blood pressure (p-value = .429; r = -.132).
Conclusion: Fat Accumulation in the kidneys where the renin-angiotensin system is identified in human fat tissue, can cause impaired nephron function which causes blood pressure to rise. Thus, abdominal obesity accompanied by ectopic fat deposits can play an important role in the development of hypertension and should not be neglected when undertaking blood pressure-lowering therapy.

Keywords: Body fat, cholesterol, elderly women.
THE RELATIONSHIP OF PHYSICAL DISTANCING WITH MENTAL HEALTH OF INDONESIAN COMMUNITY DURING COVID-19
Authors: Yuniarti Enny Virda , Andriyanto Arief 
Published: June 2021

Background: The spread of the COVID-19 virus has spread widely throughout the world, which affects various aspects (Lebov et al., 2017). Several aspects affected by the transmission of the COVID-19 virus are psychological / mental health impacts caused by the implementation of policies from various countries in the form of a physical distancing system (Ornell, Schuch, Sordi, & Kessler, 2020).
Objectives: Analyze the relationship between physical distancing and the mental health of Indonesian community during Covid-19.
Methods: The cross-sectional study design. The sample of the study was the Indonesian people affected by the covid-19 pandemic who were taken based on purposive sampling with complete answer criteria as many as 1,090 respondents. The research instrument consisted of 2 questionnaires, including: a method questionnaire in physical distancing practices methods consisting of 11 items of physical distancing application to prevent the spread of the Covid-19 virus as recommended by World Health Organization. The Self-Reporting Questionnaire-29 is a questionnaire issued by the Directorate of Mental Health Services of the Indonesian Ministry of Health with the domains of anxiety and depression, psychomatics, symptoms of psychotic disorders, trauma stress. Parametric statistical tests used the Pearson test (p-value < 0.05).
Results: The results obtained a p-value of 0.03, which means that there is a physical distancing relationship with the mental health of the Indonesian people during Covid-19.
Conclusion: There is a significant relationship between physical distancing and the mental health of the Indonesian people. Recommendations for health workers, especially nurses in providing health services to the community, must be more comprehensive and recognize client responses to prevent psychological impacts.

Keyword: Physical distancing; mental health; covid-19 pandemic.