bluuebunny/crossref_metadata_2025_split huggingface dataset:
JAK-STAT Signaling Enables Lineage Plasticity-driven AR Targeted Therapy Resistance
Authors: Deng Su , Wang Choushi , Wang Yunguan , Xu Yaru , Li Xiaoling , Johnson Nickolas A , Lo U-Ging , Xu Lingfan , Gonzalez Julisa , Metang Lauren A , Ye Jianfeng , Tirado Carla Rodriguez , Rodarte Kathia , Xie Zhiqun , Arana Carlos , Annamalai Valli , Hsieh Jer-Tsong , Vander Griend Donald J. , Li Bo , Wang Tao , Mu Ping 
Published: November 2021

AbstractEmerging evidence indicates that various cancers can gain resistance to targeted therapies by acquiring lineage plasticity. Although various genomic and transcriptomic aberrations correlate with lineage plasticity-driven resistance, the molecular mechanisms of acquiring lineage plasticity have not been fully elucidated. Through integrated transcriptomic and single cell RNA-Seq (scRNA-Seq) analysis of more than 80,000 cells, we reveal for the first time that the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling is a crucial executor in promoting lineage plasticity-driven AR targeted therapy resistance in prostate cancer. Ectopic activation of JAK-STAT signaling is specifically required for the AR targeted therapy resistance of subclones expressing multilineage, stem-like and epithelial-to-mesenchymal transition (EMT) lineage transcriptional programs and represents a potential therapeutic target for overcoming AR targeted therapy resistance.One-Sentence SummaryJAK-STAT signaling is a crucial executor in promoting lineage plasticity-driven AR therapy resistance in prostate cancer.
N4BP1 is dimerization-dependent linear ubiquitin reader regulating TNFR1 signalling through linear ubiquitin binding and Caspase-8-mediated processing
Authors: Kliza Katarzyna , Song Wei , Pinzuti Irene , Schaubeck Simone , Kunzelmann Simone , Kuntin David , Fornili Arianna , Pandini Alessandro , Hofmann Kay , Garnett James A. , Stieglitz Benjamin , Husnjak Koraljka 
Published: November 2021

AbstractSignalling through TNFR1 modulates proinflammatory gene transcription and programmed cell death, and its impairment causes autoimmune diseases and cancer. NEDD4-binding protein 1 (N4BP1) was recently identified as a critical suppressor of proinflammatory cytokine production1, whose mode of action remained unknown. Here, we show that N4BP1 is a novel linear ubiquitin reader that negatively regulates NFκB signalling by its unique dimerizationdependent ubiquitin-binding module that we named LUBIN. Dimeric N4BP1 strategically positions two non-selective ubiquitin-binding domains to ensure exclusive recognition of linear ubiquitin. Under proinflammatory conditions, N4BP1 is recruited to the nascent TNFR1 signalling complex, where it regulates duration of proinflammatory signalling in LUBIN-dependent manner. N4BP1 deficiency accelerates TNFα-induced cell death by increasing complex II assembly. Under proapoptotic conditions, Caspase-8 mediates proteolytic processing of N4BP1 and the resulting cleavage fragment of N4BP1, which retains the ability to bind linear ubiquitin, is rapidly degraded by the 26S proteasome, accelerating apoptosis. In summary, our findings demonstrate that N4BP1 dimerization creates a unique linear ubiquitin reader that ensures timely and coordinated regulation of TNFR1-mediated inflammation and cell death.
Vegetative Phase Change Causes Age-Dependent Changes in Phenotypic Plasticity
Authors: Lawrence-Paul Erica H. , Poethig R. Scott , Lasky Jesse R. 
Published: November 2021

SummaryPhenotypic plasticity allows organisms to optimize traits for their environment. As organisms age, they experience diverse environments that benefit from varying degrees of phenotypic plasticity. Developmental transitions can control these age-dependent changes in plasticity and as such, the timing of these transitions can determine when plasticity changes in an organism.Here we investigate how the transition from juvenile-to adult-vegetative development known as vegetative phase change (VPC) contributes to age-dependent changes in phenotypic plasticity and how the timing of this transition responds to environment using both natural accessions and mutant lines in the model plantArabidopsis thaliana.We found that the adult phase of vegetative development has greater plasticity in leaf morphology than the juvenile phase and confirmed that this difference in plasticity is caused by VPC using mutant lines. Further, we found that the timing of VPC, and therefore the time when increased plasticity is acquired, varies significantly across genotypes and environments.The consistent age-dependent changes in plasticity caused by VPC suggest that VPC may be adaptive. This genetic and environmental variation in the timing of VPC indicates the potential for population-level adaptive evolution of VPC.
SorCS2 dynamically interacts with TrkB and GluN2B to control neurotransmission and Huntington’s disease progression
Authors: Salašová Alena , Degn Niels Sanderhoff , Paveliev Mikhail , Madsen Niels Kjærgaard , Benito Saray López , Casarotto Plinio , Ovesen Peter Lund , Vestergaard Benedicte , Udrea Andreea Cornelia , Kisiswa Lilian , Woloszczuková Lucie , Faress Islam , Nabavi Sadegh , Castrén Eero , Arévalo Juan Carlos , Holm Mai Marie , Kjølby Mads Fuglsang , Bølcho Ulrik , Nykjaer Anders 
Published: November 2021

ABSTRACTBackgroundHuntington’s disease (HD) is a fatal neurodegenerative disorder characterized by progressive motor dysfunction and loss of medium spiny neurons (MSNs) in dorsal striatum. Brain-derived neurotrophic factor (BDNF) sustains functionality and integrity of MSNs, and thus reduced BDNF signaling is integral to the disease. Mutations in BDNF receptor SorCS2 were recently identified in HD patients. Our study investigates the role of SorCS2 in MSNs biology and in HD progression.MethodsWe derived a double transgenic line by crossbreeding SorCS2 deficient (KO) mice with the HD mouse model R6/1. Subsequently, we characterized the SorCS2 KO; R6/1 line by a set of behavioral and biochemical studies to evaluate phenotypes related to HD. Moreover, in combination with electrophysiology and super resolution microscopy techniques, we addressed the molecular mechanism by which SorCS2 controls synaptic activity in MSNs neurons.ResultsWe show that SorCS2 is expressed in MSNs with reduced levels in R6/1 HD model, and that SorCS2 deficiency exacerbates the disease progression in R6/1 mice. Furthermore, we find that SorCS2 binds TrkB and the NMDA receptor subunit GluN2B, which is required to control neurotransmission in corticostriatal synapses. While BDNF stimulates SorCS2-TrkB complex formation to enable TrkB signaling, it disengages SorCS2 from GluN2B, leading to enrichment of the subunit at postsynaptic densities. Consequently, long-term potentiation (LTP) is abolished in SorCS2 deficient mice, despite increased striatal TrkB and unaltered BDNF expression. However, the addition of exogenous BDNF rescues the phenotype. Finally, GluN2B, but not GluN2A, currents are also severely impaired in the SorCS2 KO mice.ConclusionsWe formulate a novel molecular mechanism by which SorCS2 acts as a molecular switch. SorCS2 targets TrkB and GluN2B into postsynaptic densities to enable BDNF signaling and NMDAR dependent neurotransmission in the dorsal striatum. Remarkably, the binding between SorCS2 and TrkB or GluN2B, respectively, is mutually exclusive and controlled by BDNF. This mechanism provides an explanation why deficient SorCS2 signaling severely aggravates HD progression in mice. Moreover, we provide evidence that this finding might represent a general mechanism of SorCS2 signaling found in other brain areas, thus increasing its relevance for other neurological and psychiatric impairments.
Design, modeling and simulation of a control surface-less tri-tilt-rotor UAV
Authors: Annamalai Vinoth Kumar , Thunaipragasam Selvakumaran 
Published: November 2021

Purpose
The purpose of this study is to design a flight control model for a control surface-less (CSL) tri-tilt-rotor (TTR) unmanned aerial vehicle (UAV) based on a Proportional Integral Derivative (PID) controller to stabilize the altitude and attitude of the UAV subjected to various flying conditions.

Design/methodology/approach
First, the proposed UAV with a tilting mechanism is designed and analyzed to obtain the aerodynamic parameters. Second, the dynamics of the proposed UAV are mathematically modeled using Newton-Euler formation. Then, the PID controller is implemented in the simulation model to control flight maneuvers. The model parameters were implemented in a mathematical model to find the system’s stability for various flight conditions. The model was linearized to determine the PID gain values for vertical take-off and landing, cruise and transition mode. The PID controller was tuned to obtain the desired altitude and attitude in a short period. The tuned PID gain values were implemented in the PID controller and the model was simulated.

Findings
The main contribution of this study is the mathematical model and controller for a UAV without any control surface and uses only a thrust vector control mechanism which reduces the complexity of the controller. The simulation has been carried out for various flight conditions. The altitude PID controller and the attitude PID controller for CSL-TTR-UAV were tuned to obtain desired altitude and attitude within the optimum duration of 4 s and deviation in the attitude of 8%, which is within the allowable limit of 14%. The findings obtained from the simulation revels that the altitude and attitude control of the CSL-TTR-UAV was achieved by controlling the rpm of the rotor and tilt angle using the PID controller.

Originality/value
A novel CSL TTR UAV mathematical model is developed with a dual tilting mechanism for a tail rotor and single axis tilt for the rotors in the wing. The flight control model controls the UAV without a control surface using a PID controller for the thrust vector mechanism.
Exploration of constructing the catering quality indices of university canteens in China from the viewpoint of food safety
Authors: Ji Yugang , Ko Wen-Hwa 
Published: November 2021

PurposeThis study used the literature review and the modified Delphi method to evaluate the importance of the catering quality indices of university canteens in China. In order to compile the catering quality indices of university canteens in China as reference for the subsequent improvement of Chinese canteens.Design/methodology/approachThis study first analysed literature data to establish the preliminary quality indices and used the modified Delphi method for measurement. After three rounds of Delphi analysis by 35 experts, the results of the catering quality indices of university canteens in China are summarised.FindingsThe research results show that university canteen catering quality issues are divided into six dimensions, including catering safety management, employee hygiene management, catering service, food quality, environmental atmosphere and corporate social responsibility. Catering safety management is the most important index, followed by employee hygiene management.Originality/valueThe research results can be used as suggestions for follow-up improvements in the quality of university canteens in China and a basis of reference for amendments to relevant national or local laws and regulations. The food prices, food quality and whether food hygiene and safety standards are met by university canteens are all related to the health and vital interests of the teachers and students, as well as the stability of the university. Therefore, the government should increase supervision in these aspects to avoid decline in the quality of meals due to low profits and enforce strict requirements for food safety.
Youth entrepreneurial intentions: an integrated model of individual and contextual factors
Authors: Gulzar Farzana , Fayaz Aiman 
Published: November 2021

Purpose
The purpose of this study is to identify factors instrumental in developing entrepreneurial intentions among youth. Although, numerous studies have been conducted focusing on entrepreneurship intention, however, this study attempts to provide an integrated model by means of analyzing the impact of internal (personal) and external (environmental) factors in developing entrepreneurial intentions.

Design/methodology/approach
This cross-sectional study is based on primary and secondary data. A sample of 358 respondents belonging to the age group of 21–25 years from various universities and colleges in Kashmir participated in the study. Primary data collection was done using self-administered questionnaires. A purposive sampling approach was used to identify respondents for the current study. Structural equation modeling has been used for testing hypotheses besides other statistical methods and techniques.

Findings
The study identifies three important antecedents of entrepreneurship intentions, namely, personal competencies, contextual factors and entrepreneurial exposure and tests the relationships using path analysis. It further suggests that there exists a significant relationship between personal competencies, entrepreneurial exposure, contextual elements and entrepreneurial intention.

Originality/value
The paper presents an integrated and comprehensive model of entrepreneurial intentions discussing important antecedents instrumental in developing entrepreneurship intentions among youth considering both personal and environmental factors. It is, therefore, an important contribution toward entrepreneurship literature and of interest to different policymakers and institutions related to entrepreneurship.
A fuzzy comprehensive evaluation of climate change on the Xiamen tourism industry
Authors: Bethel Brandon J. , Tang Decai , Wang Linjia , Buravleva Yana 
Published: November 2021

Purpose
Climate change is most apparent through the increased severity and frequency of extreme events. Tourism as an activity is particularly sensitive. This paper aims to investigate the impact that climate change has on Xiamen tourism through a fuzzy comprehensive evaluation of questionnaire responses.

Design/methodology/approach
A fuzzy classification system of tourism factors most sensitive to climate change was built on the basis of an analytical hierarchical process.

Findings
A “relatively strong” association grade of the impacts of climate change on tourism was observed. Through fuzzy comprehensive evaluation, the method used has allowed for clear classification of the aspects of tourism, through its development, which are more vulnerable to climate change. The results acquired here can serve as reference material for stakeholders on implementing risk assessments, deepening the understanding of how climate change affects tourism and coordinate the interests of different parties through the achievement of focused development and realize the optimum, long-term and sustainable exploitation of tourism resources.

Originality/value
The sensitivity of a variety of tourist sectors within Xiamen was assessed and represents the newest pre-COVID-19 opinions concerning the effect of climate change on tourism. Additionally, the data used in this study was also collected before the outbreak of the COVID-19 pandemic and will serve as an important marker to track how expert opinions of the effects of climate change on tourism change over time.
Integrating building information modelling for improving facility management operations: a fuzzy synthetic evaluation of the critical success factors
Authors: Oluleye Ifeoluwa Benjamin , Oyetunji Abiodun Kolawole , Olukolajo Michael Ayodele , Chan Daniel W.M. 
Published: November 2021

Purpose
Building information modelling (BIM) is a novel technological advancement in the built environment. Despite the potentials of BIM, its adoption and implementation are undermined in facility management (FM) operations. This might be because of limited information on the critical success factors (CSFs) that can enhance its adoption. The study aims to integrate building information modelling to improve facility management operation by adopting fuzzy synthetic approach for evaluating the critical success factors.

Design/methodology/approach
Data for the study were sourced from practising and registered facility managers within Lagos metropolis, Nigeria. The data collected were analysed using a combination of methods which include mean item score, factor analysis and fuzzy synthetic evaluation (FSE).

Findings
The factor analysis results showed that six underlying groups of CSFs would enhance the effective adoption of BIM in facility operations. The FSE results showed that out of the six groups, the three topmost important CSF grouping (CSFG) in the decision rule would enhance the effectiveness of BIM adoption for FM operations.

Practical implications
The result of this study provides a credible road map for facility managers, policymakers and other stakeholders in FM operations on the CSFs and CSFG required for the adoption of BIM.

Originality/value
Previous studies that aimed at integrating BIM into FM are limited. Hence, this study provides a broad perspective on the CSF required for BIM adoption and implementation in FM operations using the FSE approach.
Empowerment of SME’s sustainability in halal cosmetics’ ecosystem by diagnosing growth constraints
Authors: Masood Adlin , Zaidi Aisyah 
Published: November 2021

Purpose
This study aims to identify and examine the growth constraints of the halal cosmetics ecosystem in which SMEs are operating in, with special focus on the situation in Malaysia.

Design/methodology/approach
The study adopted a qualitative methodology consisting of a systematic literature review and interviews with selected consumers and policymakers. The instruments were developed based on cybernetics and a systems-based approach, which allows for the understanding of the dynamics of growth variables in the halal cosmetics ecosystem. Based on data gathered, their relationships were mapped and major growth constraints were identified.

Findings
Cybernetics and systems approach coupled with growth diagnostics framework has enabled identification of comprehensive growth constraint variables for halal cosmetics ecosystem and mapping of growth constraints (variables) in a relationships network. The study found that the enforcement activities of the National Pharmaceutical Research Agency (Cosmetics Unit) directly affect five growth constraints and is associated with three other growth constraint variables; subsequently the most binding growth constraint. The relationship network derived from the mapping of the growth constraints indicated that changes in the behaviour of any element will affect the overall operations of the ecosystem.

Research limitations/implications
While the cosmetics industry is large and varied, this study is centred on halal colour cosmetics only. The growth constraint variables studied are those chosen by researchers and other growth constraints could be studied to guide policymakers. Future research can revolve around other halal cosmetics business sectors; impact of IR4.0 technology, COVID-19 pandemic impact; crisis and risk management issues, in the halal cosmetics industry.

Practical implications
The results derived from the cybernetics analysis affirms the “outside-in” marketing perspective, thus stakeholders should continuously monitor changes in the halal cosmetics ecosystem to ensure to ensure sustainability and profitability. Small and medium enterprises (SMEs) and policymakers can initiate pre-emptive actions by conducting simulations of various situations on the halal ecosystem.

Social implications
Enabled to simulate the effect of changes to the halal cosmetics ecosystem, stakeholders are able to take intervention initiatives, safeguard accessibility to halal cosmetics and make the halal cosmetics industry sustainable.

Originality/value
To the best of the authors’ knowledge, this is the first comprehensive research to identify the growth constraints of the halal cosmetics industry in Malaysia that focusses on three groups of stakeholders (consumers, SMEs and government institutions) concurrently. The growth constraints relationship network of the halal cosmetics ecosystem can be further used to simulate the impact of changes within the system.
Electronic fraud: an emerging cause of bank failure in Nigerian deposit money banks
Authors: Akinwale Folowosele Folarin , Ailemen Ikpefan Ochei , Areghan Isibor 
Published: November 2021

Purpose
This study aims to review the degree to which fraud and other unethical practices especially in the digital space have affected the Nigerian banking industry both in the past and present, and how it will be a growing concern in the imminent future. The objective of the study was to examine the impact of electronic fraud on the quality of assets and return on assets of Nigerian deposit money banks.

Design/methodology/approach
The research used secondary data for the periods 2006 till 2018, which were collected from the Nigeria Deposit Insurance Corporation annual reports. Descriptive analysis and the ordinary least square method of regression analysis were used for data analysis.

Findings
Findings revealed that electronic fraud cases increased progressively over most of the years of study, which can be attributed to the increased bank products that are electronic-based.

Originality/value
Many of the reviewed literature examined electronic fraud and its impact on bank profitability but this study examined the cause of electronic fraud and what can be done to curtail it.