bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALYSIS OF TRANSLATION TECHNIQUES OF 'UCHIAGE HANABI' SONG AND COVERSONG BY ANDI ADINATA
Authors: Rakanti Sean Annisa , Novitasari Raden 
Published: February 2025

The aims of this research is to describe the single translation technique and the multiple translation technique applied to the lyrics of the song 'Uchiage Hanabi' covered by Andi Adinata's song into Indonesian. In this research, the data are taken from video of Andi Adinata. The theories of translation technique used is the theory of Molina and Albir . The method used a descriptive qualitative method which consists of three stages, namely, the data collection stage, the data analysis and the presentation of the data analysis results. The data collection methods and techniques used are the listening method and the note-taking technique. Data analysis methods and techniques used are intralingua matching methods and determining element sorting techniques. The method used in presenting the results of data analysis is an informal presentation method. The results of this study indicate that there are 5 types of single translation techniques, namely 1 data literal translation technique, 2 data of modulation translation techniques, word to word is 5 data translation techniques, common equivalent translation techniques 2 data and 2 data amplification translation techniques, and the types of multiple translation techniques, namely amplification translation techniques with 4 data literals, amplification translation techniques with 1 data modulation, modulation translation techniques with 3 literals data and modulation translation techniques with the usual equivalent 2 data.
Multidrug-Resistance and Biofilm Formation among Acinetobacter baumannii Isolated from Clinical Specimens
Authors: Yadav Poonam , Shyam Kumar Mishra  , Shrestha Sreska , Sah Ranjit , Rai Junu Richhinbung , Kattel Hari Prasad , Sharma Sangita , Willcox Mark 
Published: February 2025

Background: Acinetobacter baumannii has emerged as a problematic pathogen due to its ability to become resistant to antibiotics and form biofilms. The aim of this study was to explore antibiotic resistance and biofilm formation, and examine any correlation between these in Acinetobacter baumannii isolates.Methods: This was a cross-sectional study conducted at the 750-bed Tribhuvan University Teaching Hospital in Nepal. Identification and antibiotic sensitivity of Acinetobacter baumannii isolates were performed following American Society for Microbiology guidelines. Different β-lactamases were detected by standard phenotypic tests. The microtiter plate method was used to screen strains of their ability to form biofilms. Results: Out of total 18,343 clinical samples processed, 4,249 (23.1%) showed bacterial growth. A. baumannii comprised of 4.7% of the total bacterial growth. Multidrug-resistant (MDR) was exhibited by 97.5% of Acinetobacter baumannii isolates. All multidrug-resistant Acinetobacter baumannii isolates were resistant to cephalosporins and carbapenems; however, they were sensitive to polymyxins. Only few isolates showed sensitivity to sulbactam-containing antibiotics (15.4-29.2%), fluoroquinolones (1.0-7.2%), aminoglycosides (2.6-5.6%), and cotrimoxazole (4.1%). Extended-spectrum-beta-lactamase (ESBL), metallo-beta-lactamase (MBL), Klebsiella pneumoniae carbapenemase (KPC) and AmpC production were found in 54.9%, 73.3%, 41.5% and 14.9% isolates, respectively. Among all tested isolates, 192 were able to produce biofilms, with 83.1% being classified as strong biofilm producers. Those strains that were resistant to gentamicin were more likely to produce biofilms (P<0.05). ESBL, MBL, KPC and AmpC were seen in 51.8%, 71.6%, 43.8% and 16.0% of strong biofilm producers respectively. Conclusions: Only polymyxins were effective against Acinetobacter baumannii. Carbapenemase producers were generally strong biofilm producers, and gentamicin resistant strains were more likely to produce biofilms. The findings of this study may help to understand antibiotic-resistance mechanisms and provide valuable information in the treatment of MDR Acinetobacter baumannii infections.Keywords: Acinetobacter baumannii, biofilm, carbapenemase; multidrug-resistant.
Koulun keskimääräisen osaamistason merkitys peruskoulun matematiikan päättöarvosanan vertailukelpoisuuteen
Authors: Luhtajärvi Heidi , Betanzos Maria , Vainikainen Mari-Pauliina 
Published: February 2025

Tässä tutkimuksessa tarkastellaan peruskoulun matematiikan päättöarvosanojen vertailukelpoisuutta tutkimalla matematiikan osaamisen ja päättöarvosanojen vaihtelua koulutasolla, osaamisen ja päättöarvosanojen vastaavuutta sekä päättöarvosanan vaihteluun vaikuttavia tekijöitä. Tutkimuksen keskiössä on koulun keskimääräisen osaamistason heijastuminen päättöarvosanaan, ja tätä tarkastellaan myös koulumenestykseltään eritasoisten oppilaiden ryhmissä. Aineistona hyödynnetään valtakunnallista oppimaan oppimisen arviointia keväältä 2017 sekä siihen yhdistettyjä yhteishakurekisteritietoja päättöarvosanoista keväältä 2017 (N=7947 oppilasta 85 koulusta). Aineisto analysoitiin kaksitasoisella hierarkkisella lineaarisella regressioanalyysillä, varianssikomponenttianalyysillä sekä kaksitasoisella korrelaatioanalyysillä. Koulun keskimääräinen osaamistaso vaikutti arvosanaan negatiivisesti siten, että korkeamman osaamistason koulussa oli hieman tiukempi linja päättöarvosanojen antamisen suhteen, ja tämä vaikutus korostui erityisesti koulumenestykseltään keskitasoisten oppilaiden ryhmässä. Tutkimus todistaa jo aiemmin havaitun ilmiön, että päättöarvioinnin vertailukelpoisuudessa on epäkohtia eivätkä päättö arvosanat toimi osaamisen validina mittarina. Jatkossa olisi edelleenkin tärkeä kehittää arvioinnin yhdenvertaisuutta tarkastelemalla uudistettujen arviointikriteerien toimivuutta, jotta etenemme kohti koulutuksellista tasa-arvoa.
Educación Familiar un reto en la Escuela Pedagógica “Manuel Ascunce Domenech”
Authors: Miranda Vizcaino Adelidis 
Published: February 2025

O tratamento da família na educação dos alunos constitui um tema onde se revela a relação: família, escola e comunidade para consolidar o desenvolvimento cognitivo do aluno a partir de uma visão integradora. Um programa Escolas de Educação Familiar é proposto como objetivo contribuir para. o desenvolvimento cognitivo dos alunos matriculados na Escola Pedagógica “Manuel Ascunce Domnech”[1] como futuros profissionais da educação. Através da pesquisa, serão utilizados métodos teóricos, empíricos e estatísticos para determinar os pontos fortes e fracos das famílias para a educação no desenvolvimento cognitivo. A proposta desenvolvida permitiu demonstrar a partir dos indicadores avaliados que na família existe um processo de internalização e identificação no que diz respeito às ações que a família deve realizar no desenvolvimento cognitivo e atitudinal de seus filhos. A aplicação do programa Escolas de Educação Familiar oferece orientação e permite que os pais recebam conselhos para estimular a memória, a imaginação, a criatividade e o pensamento para contribuir para a elevação da qualidade do ensino nesta instituição.

[1] Escola Pedagógica é um centro de formação de professores para nível médio e educação infantil de diferentes especialidades. Há uma escola em cada província do pais e se vincula a teoria com a prática e componente de trabalho, prática sistemática nas instituições educativas do território.
Cell-free regenerative medicine: identifying the best source of mesenchymal stem cells for skin therapy in Systemic Sclerosis
Authors: Napolitano Filomena , Giudice Valentina , D’Esposito Vittoria , Prevete Nella , Scala Pasqualina , de Paulis Amato , Selleri Carmine , Formisano Pietro , Rossi Francesca Wanda , Montuori Nunzia 
Published: February 2025

IntroductionSystemic Sclerosis (SSc) is a rare chronic systemic autoimmune disease characterized by fibrosis of the skin and internal organs and vasculopathy. Raynaud’s phenomenon is typically the earliest clinical manifestation accompanied by skin inflammation, finger ulcers, and organ manifestations, including pulmonary fibrosis. There is an urgent need for the development of effective targeted therapeutic intervention for SSc patients. A greater focus has been placed on bioactive factors secreted by Mesenchymal Stem Cells (MSCs), with immunomodulatory and regenerative potentials. Current data report a different secretion profile of MSCs, depending on the tissue of origin. Understanding of the secretion profile of different MSCs is necessary to identify the most efficient and useful source for SSc treatment.MethodsWe analyzed the content of MSC-conditioned media (MSC-CM) obtained from MSCs isolated from adipose tissue (AT), bone marrow (BM), Wharton’s jelly (WJ), and cord blood (CB) by ELISA method, and their effects on the wound healing process by fibroblast proliferation, migration, and ECM deposition assays, to compare regenerative potential of different MSC populations.ResultsWJ-MSC-conditioned medium (CM) and BM-MSC-CM show a greater regenerative profile, compared to CB-MSC-CM and AT-MSC-CM, due to the abundance of growth factors and immunomodulatory cytokines and the effects on fibroblast functions. In SSc fibroblasts, WJ-MSC-CM significantly promotes fibroblast-mediated wound healing processes and VEGF expression, compared to BM-MSC-CM.DiscussionOur data indicate that WJ-MSC-CM could be considered an appealing strategy to both topical and systemic administrations in SSc patients.
Characterization of clustered bacteriocin-type signal domain protein genes in Treponema denticola
Authors: Nukaga Tomoyuki , Kokubu Eitoyo , Okamoto-Shibayama Kazuko , Kikuchi Yuichiro , Furusawa Masahiro , Muramatsu Takashi , Ishihara Kazuyuki 
Published: February 2025

BackgroundPeriodontitis is caused by the dysbiosis of subgingival plaque, and Treponema denticola is the pathogen associated with this disease. Bacteriocins are involved in interbacterial competition during dysbiosis. In our previous study, three potential bacteriocin ABC transporter genes (tepA1-B1, tepA2-B2, and tepA3-B3) of T. denticola were investigated. Upstream of tepA1-B1, three genes annotated as bacteriocin-type signal domain proteins are located. However, the role of these proteins in T. denticola remains unclear. In the present study, these bacteriocin-type signal domain proteins were characterized to elucidate their putative roles in T. denticola.MethodsGene clusters surrounding bacteriocin-type signal domain protein genes were compared in silico. The expression of proteins and transporters was evaluated using real-time quantitative reverse transcription PCR (qRT-PCR). Bacteriocin-type signal domain proteins were detected using immunoblot analysis. The expression of bacteriocin-like proteins was investigated by co-culturing with Treponema vincentii.ResultsThe DNA sequences of the bacteriocin-type signal domain protein genes and upstream lipoprotein genes were highly conserved. Expression of the bacteriocin-type signal domain protein and tepA1 was slightly higher in the mid-log phase than in the stationary phase and was reduced upon co-culture with T. vincentii. Bacteriocin ABC transporter gene tepA1 was expressed independently of tepA2 and tepA3. Immunoblot analysis detected bacteriocin-like proteins in culture supernatants. However, bactericidal activity was not detected in the culture supernatant of T. denticola.ConclusionThree tandem lipoprotein-bacteriocin-type signal domain protein genes may have originated from duplication. Bacteriocin-type signal domain proteins are expressed under unstimulated conditions and are secreted by T. denticola cells.
Sex-specific differences in the relationship between fasting plasma glucose and carotid plaque in a cardiovascular high-risk population: a cross-sectional study
Authors: Xu Mengjie , Xu Kai , Lin Weiguo , Sun Ruixue , Yan Shaorong , Chen Xiaoshu , Lin Yuzhan 
Published: February 2025

BackgroundDespite extensive research on the epidemiological risk factors linking diabetes and carotid plaques, evidence regarding sex-specific differences remains scarce. This study aims to investigate the gender differences in the association between fasting blood glucose levels and the risk of carotid plaques among cardiovascular high-risk populations.MethodsThis study used cross-sectional data from a large prospective cohort study. From 2019 to 2020, fasting blood glucose and carotid ultrasound examinations were conducted on high-risk cardiovascular populations in the pilot area. The independent variable was fasting blood glucose, and the dependent variable was the presence or absence of carotid plaques. A multivariable logistic regression model was used to calculate risk ratios. Generalized additive models combined with curve fitting were employed to assess the nonlinear relationship between fasting blood glucose levels and carotid plaques in the overall population and different genders.ResultsThis study included 1,063 cardiovascular high-risk patients. In the fully adjusted model, fasting blood glucose levels in men were positively associated with carotid plaques (OR = 1.21, 95% CI: 1.02-1.45, p = 0.0312). In women, fasting blood glucose levels were also positively associated with the risk of carotid plaque formation (OR = 1.15, 95% CI: 0.95-1.39). The generalized additive model results showed a linear relationship between fasting blood glucose levels and carotid plaques in the overall population. Stratified results indicated a linear relationship in men, while a nonlinear relationship was observed in women.ConclusionThere is an association between fasting blood glucose levels and carotid plaque, with an increased risk of carotid plaque as fasting blood glucose rises. Moreover, this relationship differs between sexes.
Fibrinogen-to-albumin ratio: a new biomarker to identify inflammatory bowel disease in active stage
Authors: Chen Xiao-Fu , Huang Zhi-Ming , Huang Xie-Lin 
Published: February 2025

IntroductionThe objective of our study was to externally validate the value of the fibrinogen-to-albumin ratio (FAR), a new biomarker used to identify active inflammatory bowel disease (IBD).Materials and methodsA total of 245 ulcerative colitis (UC) and 543 Crohn’s disease (CD) patients were included in our study. Multivariate logistic regression analysis was used to investigate the independent association between FAR and disease activity in patients with UC or CD. The area under the receiver operating characteristic curve was used to assess the prediction accuracy of biomarkers in distinguishing disease states.ResultsMultivariate logistic regression analysis identified the FAR as the strongest predictor to discriminate disease activity of UC (odds ratio: 24.871, 95% confidence interval: 9.831–38.912, p &lt; 0.001) and CD (odds ratio: 28.966, 95% confidence interval: 21.009–37.250, p &lt; 0.001). The FAR gave the highest area under the curve in identifying both active UC (0.870, 95% confidence interval: 0.824–0.916) and CD (0.925, 95% confidence interval: 0.904–0.946). The probability of both UC and CD patients being in the active stage significantly increased when the FAR was more than or equal to the optimal cutoff values.ConclusionThe FAR, a simple prognostic indicator, performs well in identifying active IBD.
The nonlinear relationship between the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol and the risk of diabetic kidney disease in patients with type 2 diabetes mellitus
Authors: Cai Dan-Xuan , Huang Ye-Hong , Lin Ni-Na , Zhang Yun-Feng , Huang Shu-Qin , Han Yun , Hu Xin-Yu , Cai Song-Tao , Tao Yan-Ling 
Published: February 2025

BackgroundThe ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) is a novel marker related to atherosclerosis, but its role in diabetic kidney disease (DKD) remains unclear. This study investigated the relationship between NHHR and DKD risk in patients with type 2 diabetes mellitus (T2DM) and evaluated its potential as a marker for early DKD screening.MethodsData from adults with T2DM participating in the National Health and Nutrition Examination Surveys (NHANES) from 1999 to 2018 were analyzed. Demographic information, laboratory tests, and other relevant information were collected. To evaluate the correlation between NHHR levels and DKD risk, weighted multivariable logistic regression and weighted restricted cubic spline (RCS) analyses were employed. Furthermore, threshold effect analysis was employed to further explore the relationship at different NHHR levels, and subgroup analyses validated the results.ResultsThe study enrolled a total of 3,243 participants, comprising 1,258 individuals with DKD (38.79%) and 1,985 individuals without DKD (61.21%). The multivariable logistic regression analysis showed that T2DM patients with higher NHHR levels exhibited a 45% reduction in the risk of developing DKD in comparison to those with lower NHHR levels (Q2 vs. Q1: OR 0.55, 95% CI 0.40–0.76). The weighted RCS analysis revealed a nonlinear correlation between NHHR and the risk of DKD in patients with T2DM (P for nonlinear = 0.003), with the RCS plot exhibiting an L-shaped association. A negative association was observed between NHHR levels and the risk of DKD when NHHR was ≤2.82 (OR 0.63, 95% CI 0.49–0.83). A statistically significant correlation between NHHR and DKD risk was not observed when NHHR was &gt;2.82. The subgroup analyses indicated that age may have an interaction effect on this association at higher NHHR levels (p for interaction&lt;0.05).ConclusionOur findings revealed a non-linear relationship between the NHHR levels and the risk of DKD in adult T2DM patients in the United States. Managing the NHHR levels in the right range in T2DM patients can help reduce the risk of DKD. This suggests that NHHR may be a valuable and easily measurable biomarker for identifying those at risk for DKD, thereby promoting early intervention and improved disease management.
Case report: Upper gastrointestinal bleeding associated with pancreatic segmental portal hypertension: six case reports and literature review
Authors: Miao Qian , Zheng Zhongqing , Piao Meiyu , Cao Hailong , Wang Bangmao , Liu Wentian 
Published: February 2025

BackgroundPancreatic segmental portal hypertension (PSPH) is a clinical syndrome in which splenic vein hypertension is caused by obstruction, stenosis, or thrombosis of the splenic veins in the primary pancreatic disease. Gastrointestinal hemorrhage caused by gastric varices (GVs) is one of the life-threatening complications in the patients with left portal hypertension. The aim was to report our experience and discuss the manifestations, management, and prognosis of PSPH with upper gastrointestinal bleeding (UGIB).MethodWe retrospectively analyzed six patients with PSPH and UGIB in our department. The clinical data were collected such as demographic information, medical history, and clinical presentation.ResultThe autoimmune pancreatitis, pancreatic tumor, pancreatic surgery, chronic pancreatitis and pancreatic pseudocyst were diagnosed in six patients, respectively. Five patients presented with hematemesis and/or melena on admission, and one patient presented with fatigue. All patients had isolated GVs. Follow-up patients were treated with portal vein stenting in one case, laparoscopic splenectomy in two cases, endoscopic gastric fundic vein embolization and injection of Cyanoacrylate Glue in one case, and improvement in conservative treatment in two cases. All patients were alive at the last follow-up.ConclusionPSPH should be seriously considered in patients with pancreatic disease with isolated GVs. It is particularly important to choose specific approaches for individual cases based on the primary disease, the severity of varicose veins and the general condition of the patients.
Gut microbiota mediates the pro-pyroptosis effect of xierezhuyubuxu decoction in hepatocellular carcinoma
Authors: Zeng Zhili , Feng Mingxuan , He Fan , Zhang Enxin , Li Xiushen , Cao Zebiao 
Published: February 2025

IntroductionXierezhuyubuxu decoction (XRZYBXD) is prepared by adding and reducing the Dahuang Zhechong Pill, which is a traditional Chinese medicinal formula in “The Synopsis of Prescriptions of the Golden Chamber”. XRZYBXD has previously been reported to have good efficacy in treating Hepatocellular carcinoma (HCC) in clinical and basic research. However, its underlying mechanism in treating HCC has not been fully elucidated. The aim of the study is to investigate the pro-pyroptosis effect of XRZYBXD in HCC and the role of gut microbiota in this process.MethodsFirstly, we executed comprehensive analyses of XRZYBXD on pyroptosis, intestinal flora, microbial metabolites and intestinal barrier function using TUNEL, IHC, ELISA, WB, Q-PCR, 16S rRNA sequencing, and untargeted metabolomics in a H22 tumor-bearing mice model. Further, through rescue experiment of antibiotics-induced microbiota depletion and fecal microbial transplantation (FMT) experiment, the mechanism of XRZYBXD promoting pyroptosis of HCC by improving intestinal flora was verified.ResultsWe found that XRZYBXD medium and high dose significantly inhibited the growth of tumor and induced pyroptosis of hepatoma cells. They also modified intestinal ecological disorders by expansion of the abundance of beneficial bacteria (such as Akkermansia muciniphila and Parabacteroides distasonis) and reduction of the abundance of harmful bacteria (such as Barnesiella intestinihominis). Accordingly, microbiota metabolites and intestinal barrier function were also significantly improved by XRZYBXD.DiscussionFurther, elimination of gut microbiota by antibiotics weakened the efficacy of XRZYBXD, and FMT with feces from the XRZYBXD high dose group achieved similar therapeutic efficacy as XRZYBXD. In brief, XRZYBXD promote pyroptosis of hepatoma cells via adjusting intestinal dysbiosis.
Machine learning-based identification of high-risk bone metastasis factors after radical prostatectomy in prostate cancer
Authors: Yang Haijun , Wei Chengxiang , Zhou Shan , Mao Fei 
Published: February 2025

BackgroundBone metastasis is a serious complication following radical prostatectomy in prostate cancer patients, significantly affecting their long-term survival. This study aims to develop a clinical predictive model utilizing Magnetic Resonance Imaging (MRI) and advanced machine learning algorithms to identify key factors that increase the risk of bone metastasis (BM).Patients and methodsThe study analyzed a cohort of 1161 prostate cancer patients, including 38 who developed bone metastasis. Preoperative T2-weighted images (T2WI) were obtained, and tumor lesions were manually delineated to extract relevant features from the imaging data. Spearman correlation analysis, the least absolute shrinkage and selection operator (LASSO) algorithm, and logistic regression were used to select and construct the model. Four machine learning algorithms—extreme gradient boosting (XGBoost), random forest (RF), support vector machine (SVM), and k-nearest neighbor (KNN)—were employed to predict BM occurrence, integrating these with clinical information.ResultsAmong the four prognostic models evaluated, the XGBoost algorithm performed the best. In the training dataset, the XGBoost model achieved an AUC of 0.926 (0.870-0.982), an accuracy of 0.847 (0.773-0.921), a sensitivity of 0.880 (0.835-0.926), and a specificity of 0.829 (0.755-0.904). In the validation dataset, the XGBoost model attained an AUC of 0.706 (0.586-0.826), an accuracy of 0.687 (0.661-0.713), a sensitivity of 0.693 (0.557-0.829), and a specificity of 0.664 (0.505-0.822). The external validation dataset yielded an AUC of 0.91, demonstrating the robust predictive capabilities of the XGBoost model.ConclusionThe predictive model for bone metastasis in prostate cancer, developed using the XGBoost machine learning algorithm, shows high accuracy and significant clinical relevance. This model provides a valuable tool for identifying high-risk patients, potentially informing better management and treatment strategies.