bluuebunny/crossref_metadata_2025_split huggingface dataset:
Omega-3 Nutrition Therapy for the Treatment of Diabetic Sensorimotor
Polyneuropathy
Authors: Menon Deepak , Lewis Evan J.  H. , Perkins Bruce A. , Bril Vera 
Published: September 2021

Abstract:
Despite advances in clinical and translational research, an effective therapeutic option
for diabetic sensorimotor polyneuropathy (DSP) has remained elusive. The pathomechanisms of
DSP are diverse, and along with hyperglycemia, the roles of inflammatory mediators and lipotoxicity
in the development of microangiopathy have been well elucidated. Omega-3 (n-3) polyunsaturated
fatty acids (PUFA) are essential fatty acids with a vital role in a number of physiological processes,
including neural health, membrane structure integrity, anti-inflammatory processes, and
lipid metabolism. Identification of n-3 PUFA derived specialised proresolving mediators (SPM),
namely resolvins, neuroprotectin, and maresins which also favour nerve regeneration, have positioned
n-3 PUFA as potential treatment options in DSP. Studies in n-3 PUFA treated animal models
of DSP showed positive nerve benefits in functional, electrophysiological, and pathological indices.
Clinical trials in humans are limited, but recent proof-of-concept evidence suggests n-3 PUFA
has a positive effect on small nerve fibre regeneration with an increase in the small nerve fiber
measure of corneal nerve fibre length (CNFL). Further randomized control trials with a longer duration
of treatment, higher n-3 PUFA doses, and more rigorous neuropathy measures are needed to
provide a definitive understanding of the benefits of n-3 PUFA supplementation in DSP.
A Comprehensive Review of the Use of Antioxidants and Natural Products in Cancer Patients Receiving Anticancer Therapy
Authors: Sur Daniel , Gorzo Alecsandra , Sabarimurugan Shanthi , Krishnan Saravana Murali , Lungulescu Cristian Virgil , Volovat Simona Ruxandra , Burz Claudia 
Published: September 2021

:Cancer is the leading cause of mortality and morbidity worldwide. The side effects of cancer treatment affect the quality of life. Cancer patients search for antioxidant dietary supplements and natural products during or after conventional cancer treatment for the alleviation of side effects, improvement of the benefits of treatment, and promotion of well-being. However, the efficacy and safety of these products remain controversial; moreover, previous data do not support the standardized use of those alternative treatments in clinics. The current study reviewed the manuscripts reporting the administration of antioxidants and natural products during cancer treatment and revised preclinical and clinical studies on various types of cancer. Most of the positive results were obtained from experimental animal models; however, human clinical studies are discouraging in this regard. Therefore, further precise and distinguishable studies are required regarding antioxidant dietary supplementation. Future studies are also needed to clarify dietary supplements’ mechanism of action and pharmacokinetics in a suitable cancer patient population that will benefit the therapeutic regimens. Despite the popularity of dietary supplements, clinicians and patients should always consider their potential benefits and risks. Patients should discuss with their physician before taking any dietary antioxidant supplements or natural products.
GC-MS Characterization, In Vitro Antioxidant, Anti-inflammatory and
Potential Antidermatophytic Activity of Citrullus lanatus Seed Oil
Authors: Pathania Ruhi , Chawla Prince , Sharma Abhishek , Kaushik Ravinder , Khan Mohammed Azhar 
Published: September 2021

Background:
Dermatophytes are well-known fungus having the capability to invade kerat-inized tissues of nails, skin, and hair, of humans and other animals, causing dermatophytosis. Citrullus lanatus (watermelon) seed is a rich source of vitamin E, essential fatty acids, and minerals, bearing var-ious health benefits. Despite the presence of many useful components, the oil is not much explored. Accordingly, the study was planned to investigate the fatty acid profiling, in vitro antioxidant, anti-inflammatory, and potential antidermatophytic activity of Citrullus lanatus seed oil against dermato-phytic strains.

Methods:
The C. lanatus oil was extracted from seeds, and fatty acid profiling was characterized by GC-MS. Further, the oil was subjected to DPPH scavenging activity, and the anti-inflammatory activity was evaluated from Bovine serum albumin assay. The antidermatophytic screening against Microsporum canis, Trichophyton rubrum, and Trichophyton mentagrophytes was carried out by agar well diffusion, broth microdilution assay, and growth kinetics assay.

Results:
The C. lanatus seed oil exhibited good antioxidant activity close to ascorbic acid, i.e., IC50- 52.22 μg/ml, 35.72 μg/ml, respectively, and the oil exhibited moderate anti-inflammatory ac-tivity (315.2 μg/ml) as that of the standard drug diclofenac sodium (174.3μg/ml). The fatty acid profiling indicates the presence of eight main compounds, out of which ç-tocopherol, butylated hy-droxytoluene, and hexadecanoic acid are predominantly present. The C. lanatus seed oil showed promising activity against T. rubrum with a lower minimum inhibitory concentration value with re-spect to positive controls, Fluconazole and Ketoconazole. The oil also had a strong effect on time-dependent kinetic inhibition against T. rubrum. This was the first report of C. lanatus seed oil against any dermatophyte.

Conclusion:
In conclusion, the study supports the exploitation of C. lanatus seed oil and its main compounds as a source of natural antioxidants, anti-inflammatory, and as a novel agent against dermatophytes for curing superficial fungal infections in the near future.
Co-administration of Saffron and Chamomile Give Additive Effects of Antidiabetic and Antioxidant Activity with In vivo Augmentation of Brain BDNF, Acetylcholine Levels and Cognitive Functions in Streptozotocininduced Diabetic Rats
Authors: Ahmad Saara , Khan Asra , Tabassum Saiqa , Batool Zehra , Ahmed Saad Bilal , Khaliq Saima , Ahuja Akash Kumar , Hashmi Amrah , Rafiq Hamna , Haider Saida 
Published: September 2021

Objectives:Co-administration of chamomile and saffron is effective against diabetes and related complications.Background:Diabetes mellitus refers to comorbidities associated with reduced release of the brain-derived neurotropic factor and disruption in the metabolism of neurotransmitters leading to depression and cognitive impairment. Allopathic medications are available for the treatment of diabetes, but there is no cure and multiple adverse effects adhere to it. The therapeutic effects of co-administered chamomile with saffron may reverse diabetes and its complications.Methods:The present study sought to test the hypothesis, conducted on eighty Sprague-Dawley rats randomly divided into eight groups (n=10), including healthy controls, diabetic controls, methanolic extract treatment groups and water decoction treatment groups with respective dosage once a day for two weeks. The dose of a single herb group in methanolic extract and water decoction was saffron 10 mg/kg and chamomile 30 mg/kg, while co-administered groups received both herbs in half doses, saffron 5 mg/kg and chamomile 15 mg/kg. Two widely used tests for the assessment of memory (elevated plus maze and novel object recognition) were used to assess the mood and memory (cognitive) performance after the treatment.Results:It was observed that all treatment groups exhibited antidiabetic effects with improved mood and enhanced memory, high antioxidant profile, increased brain-derived neurotropic factor and acetylcholine concentration. However, the effects were greater in the co-administered groups of saffron and chamomile, especially the combined water decoction group.Conclusion :The study provides the successful results of co-administration of chamomile and saffron to alleviate diabetes and related complications.
High-density Fiberboard from Wood and Keratin Fibers: Physical and
Mechanical Properties
Authors: Acda Menandro N. 
Published: September 2021

Background:
High-density Fiberboards (HDF) are widely used as a substitute for solid
wood in furniture, cabinet, construction materials, etc. Wood fibers are often used in the production
of HDF but the use of renewable materials has gained worldwide interest brought about by
global pressure to pursue sustainable development. An abundant source of renewable fibers that
can be used to produce HDF is keratin from waste chicken feathers. The goal of the study is to
investigate the use of keratin fibers in combination with wood fibers to produce HDF. No or limited
studies have been conducted in this area and if successful, it could offer an alternative utilization
for the billions of kilograms of waste feather produced by the poultry industry. HDF is a high
volume feather utilization that can reduce pollution and help solve solid waste disposal problems
in many countries.

Methods:
A series of dry-formed HDFs containing varying ratios of wood and keratin fibers
bonded by polyurethane resin were produced. The physical and mechanical properties of the
HDFs were determined.

Results :
The properties of the HDFs were affected by varying ratios of wood particles and keratin
fibers. Dimensional stability as indicated by low levels of thickness swelling (<4.6%) and water
absorption (<10%) was observed. Internal bond (2.47 MPa), MOE (5.8 GPa) and MOR (45 MPa)
values were higher or comparable to those reported in the literature.

Conclusion:
HDF formed using a combination of wood and keratin fibers bonded together by
polyurethane resin to as much as 50% keratin fibers were dimensionally stable with stiffness and
strength above the minimum requirements for general use HDF as prescribed by EN 622-5.
A Non-iterative Inverse Method for the Identification of Time and Space-Dependent Heat Sources of Multi-dimensional GMs by Boundary Temperature Data
Authors: Xu Chuang , Dong Chunying 
Published: September 2021

Background:
Detection of heat sources is frequently encountered in many fields of sci-ence and engineering and plays a significant role in monitoring and control of many engineering thermal systems.

Objective:
The objective of this paper is to estimate the space and time-dependent heat sources in multi-dimensional functionally graded materials using boundary temperature data.

Methods:
First, the dimensionless temperature at the measurement points on the boundary is ob-tained by a direct process. Then, the objective function is obtained by a series of matrix operations, and the relationship between the temperature at the measurement points and the unknown parame-ters is established. After that, the strength of the heat sources can be inversed directly by the least-square error method, then the location and number of the heat sources can be obtained directly from the strength distribution of heat sources. The coefficient expansion method and truncated singular value decomposition method are applied to reduce the ill-posed degree of the inverse process.

Results:
Through the analysis of typical 2-dimensional and 3-dimensional examples, the influence of various factors such as the type of basis functions, the circular supported radius and the meas-urement noise on the inversion results is discussed, which shows that this method can identify the strength, location and number of heat sources of FGMs well.

Conclusion:
A non-iterative inverse method based on precise integration finite element method and least-square error method is established to estimate the strength, location and number of the un-known heat sources of functionally graded materials using boundary temperature data.
Spatial Analysis to Mitigate the Spread of Covid-19 Based on Regional Demographic Characteristics
Authors: Ghazali Mochamad Firman , Tridawati Anggun , Sugandi Mamad , Anesta Aqilla Fitdhea , Wikantika Ketut 
Published: September 2021

COVID-19 is currently the hot topic of discussion by scientists because of its ability to quickly spread, in line with everyday human activities. One of the environmental factors related to climatic parameters, such as the air temperature, contributed to the spreading of COVID-19 in the last four months. Its distribution ability is no longer local as it successfully halts the important activities in many countries globally. This study aims to explain the opportunity of geospatial analysis in handling the COVID-19 distribution locally based on the characteristics of demographic data. Various data, including the confirmed positive for COVID-19, age-based population, and Landsat 8 satellite imagery data were used to determine the spatial characteristics of the COVID-19 distribution per September 2020 in Bandung, Indonesia. An inverse distance weighted (IDW), Moran's I index and local indicator spatial association (LISA), and a proposed ratio of the elderly population against the population with confirmed positive for COVID-19 (CoVE) were used as the approach to determine its distribution characteristics. The information derived from Landsat 8 satellite imagery, such as the residential area, surface temperature, and humidity based on the supervised classification, land surface temperature (LST), and the normalized difference water index (NDWI) was used to perform the analysis. The results showed that the positive population of COVID-19 was concentrated in Bandung city. However, with a Moran's I value of 0.316, not all are grouped into the same category. There are only 8, 2, 5, and 3 districts categorized as HH, HL, LL, and LH. However, the areas with a large or small number of elderlies do not always correlate with the high number of confirmed positives for COVID-19. There are only 3, 1, and 3 districts classified as HH, HL, and LL. They were represented by the values of Moran's I, for about 0.057. The positive relationship between confirmed positive for COVID-19 and the built-up area, surface temperature, humidity, and the elderly population based on the coefficient of determination (R2) were 0.03, 0.28, 0.25, and 0.019, respectively. The study also shows that the vulnerability of those areas is relatively low. The study shows that the vulnerabilities in these areas are relatively low and the recommendation for COVID-19 widespread mitigation has to consider the demographic characteristics precisely in the large scale social restrictions (LSSR).
Heritage Language and Ethnic Identity: A Study on Students' Ethnic Identity and Self-Identification in Jakarta
Authors: Lumban Batu Purnama Nancy 
Published: September 2021

This study focuses on looking at how Indonesian students view themselves as Indonesians and as members of certain ethnic groups in relation to their ability to speak in the local/heritage languages. This article also covers their attitude towards their heritage languages in comparison to English, as a foreign language. The data for this study were collected through paper-based questionnaires and semi-structured interviews. It is found that participants with the ability to speak in their local language felt more confident in stating their ethnic identity. There was also a lead to confusion of their ethnic identities, for those few who can't speak any local language. These youths are proud Indonesians, with their Indonesian languages. However, as predicted by Rini (2014), among other languages in Indonesia, English will still be a more important foreign language. This study adds that English appears to be more important than any local language to these Indonesian students.
Are prohexadione calcium and Pseudomonas fluorescens a solution to limit the spread of annual bluegrass (Poa annua L.) on football pitches?
Authors: Bohinc Tanja , Zanelli Barbara , Vidrih Matej , Trdan Stanislav 
Published: September 2021

Abstract
In 2020, a greenhouse experiment was conducted to investigate the suppression of annual bluegrass (Poa annua), which is a difficult weed to manage in cool-season in turfgrass mixtures on football pitches. The efficacy of prohexadione calcium (Pc), ethephon (Eth) and Pseudomonas fluorescens against P. annua, Lolium perenne and Poa pratensis was tested, as the latter two most commonly occur in turfgrass mixtures on football pitches. Mesotrione (Mes) was used as a positive control, and nontreated grass was used as a negative control. Only a single grass species was sown in each pot. Treatments were randomly distributed for two experiments conducted separately: first – unmown grass before the beginning of spraying and second – grass mowed before the beginning of spraying. In both experiments, plant height and the number of tillers were measured/counted several times during the growing season. In both experiments, grasses were sprayed six times with Pc, Eth and P. fluorescens, while Mes was applied twice. Based on the performed study, the efficacy of the tested products is connected to grass species and whether the grass was mowed/cut before spraying. It has been detected in the present study that spraying with Pc could reduce the height of annual bluegrass, while spraying with P. fluorescens has reduced the number of tillers. Spraying was more effective on grasses that were mowed/cut before the beginning of spraying. Mes should cause severe damage to annual bluegrass but without confirmation in this study. Results of this study have indicated that the application of Pc and P. fluorescens can inhibit the spread of annual bluegrass in football pitches; however, testing their effectiveness against P. annua under field conditions should be performed as well.
Seismic bearing capacity of shallow strip footing embedded in slope resting on two-layered soil
Authors: Debnath Litan 
Published: September 2021

Abstract
In this paper, the limit equilibrium method with the pseudo-static approach is developed in the evaluation of the influence of slope on the bearing capacity of a shallow foundation. Particle swarm optimisation (PSO) technique is applied to optimise the solution. Minimum bearing capacity coefficients of shallow foundation near slopes are presented in the form of a design table for practical use in geotechnical engineering. It has been shown that the seismic bearing capacity coefficients reduce considerably with an increase in seismic coefficient. Be sides, the magnitude of bearing capacity coefficients decreases further with an increase in slope inclination.
Cemaran Bakteri dan Residu Antibiotika Daging Babi di Pasar Tradisional Kecamatan Abiansemal dan Kuta Kabupaten Badung
Authors: Arthawan I Made , Mahatmi Hapsari , Besung I Nengah Kerta 
Published: September 2021

Penelitian ini bertujuan untuk mengetahui tingkat cemaran bakteri dan residu antibiotik daging babi, serta memberi gambaran penanganan daging yang dijual di pasar tradisional di Kecamatan Abiansemal dan Kuta, Badung. Penelitian ini merupakan studi cross-sectional menggunakan kuisioner dan pengujian cemaran bakteri dan residu antibiotik daging babi. Data kuisioner dan sampel daging dikumpulkan dari 26 penjual dari 8 pasar tradisional, selanjutnya data dianalisis secara deskriptif. Uji cemaran bakteri dilakukan dengan menghitung nilai Total Plate Count, Coliform, Escherichia coli, Salmonella sp, Staphylococcus aureus, dan Campylobacter sp. Uji residu antibiotik dilakukan dengan metode tapis secara bioassay terhadap antibiotik tetrasiklin dan penisilin. Hasil menunjukkan nilai rerata Total Plate Count 3,7 x 105 dengan kisaran 7,3 x 103 - 1,5 x 106 koloni/gram. Rerata Coliform dan Escherchia coli adalah 1,3 x 105 dan 2,1 x 104 dengan kisaran 1,1 x 103 - 4,4 x 105 koloni/gram dan 4,5 x 101 - 9,7 x 104 koloni/gram. Cemaran Staphylococus aureus adalah negatif hingga 2 x 101 koloni/gram. Cemaran Salmonella sp dan Campylobacter sp. adalah negatif. Residu antibiotik tetrasiklin dan penisilin masing-masing sebesar 15,38% dan 11,54% dari seluruh sampel daging babi. Tingkat pemahaman dan kesadaran masyarakat terhadap penanganan dan sanitasi daging adalah 50% responden kategori cukup dan 50% kategori kurang paham dan kurang sadar tentang sanitasi. Faktor yang mempengaruhi tingkat cemaran bakteri yaitu tindakan praktik higiene dan sanitasi penjual daging babi yaitu 7,7% kategori baik, 80,8% kategori cukup dan 11,5% dengan kategori kurang. Disimpulkan bahwa daging babi di pasar tradisional Kecamatan Abiansemal dan Kuta Kabupaten Badung tercemar bakteri dan mengandung residu antibiotik, serta dilihat dari aspek kesehatan masyarakat veteriner tidak layak untuk dikonsumsi.
Analisis Kesehatan Daging dan Offals Babi yang Diproduksi Rumah Pemotongan Hewan Denpasar
Authors: Swacita Ida Bagus Ngurah , Resmihariningsih Ida Ayu , Suada I Ketut , Budiasa Ketut 
Published: September 2021

Aspek keamanan pangan asal hewan perlu mendapat perhatian khusus karena penyakit yang menyerang manusia hampir 75% disebabkan oleh agen infeksi yang berasal dari hewan atau produk hewan. Tujuan penelitian ini adalah untuk menganalisis kesehatan daging dan jeroan babi produksi RPH yang berpotensi menularkan penyakit zoonosis pada manusia. Penelitian ini menggunakan metode survei eksploratif kualitatif yaitu menganalisis kesehatan daging dan jeroan babi yang diperiksa secara inspeksi, palpasi, dan incici berdasarkan perbedaan jenis kelamin (jantan dan betina) dan umur hewan (muda dan dewasa) dengan total sampel yang diperiksa masing-masing sebanyak 100 sampel. Hasil penelitian menunjukkan, seluruh daging babi tidak ditemukan kelainan atau sehat. Paru babi ditemukan nekrosis 15%, pneumoni 30%, kombinasi hemoragi dan pneumoni 5%. Jantung babi ditemukan 13% hipertrofi/hiperplasi, dan pada hati babi ditemukan 1% mengandung larva sistiserkosis.Persentase kerusakan pada betina dewasa lebih tinggidibandingkan jantan dewasa. Dapat disimpulkan bahwa daging babi produksi RPH Pesanggaran masih layak dikonsumsi, namun sebagian kecil (5-30%) jeroannya menunjukkan perubahan/kelainan yang berpotensi menularkan penyakit zoonosis pada manusia.
Isolasi dan Identifikasi Bakteri Streptococcus spp. pada Babi Penderita Porcine Respiratory Disease Complex
Authors: Swandewi Ni Kadek Meita , Besung I Nengah Kerta , Suarjana I Gusti Ketut 
Published: September 2021

Streptococcus sp. merupakan salah satu penyebab primer terjadinya Porcine Respiratory Disease Complex (PRDC). Penelitian ini dilakukan untuk mendeteksi bakteri Streptococcus sp. di saluran pernapasan babi penderita PRDC serta distribusi bakteri Streptococcus sp. pada babi pra sapih dan pasca sapih. Sebanyak 43 sampel swab rongga hidung dikumpulkan dari babi yang menunjukkan gejala penyakit PRDC seperti depresi, anorexia, dyspnea, adanya eksudat dari rongga hidung, batuk/bersin, dan pembengkakan pada persendian. Sampel berasal dari peternakan babi di kabupaten Tabanan, kabupaten Badung, dan kabupaten Gianyar. Semua sampel ditanam pada media sheep blood agar dilanjutkan dengan uji pewarnaan Gram. Koloni yang dicurigai kemudian dilakukan uji primer berupa uji katalase dan uji oksidase serta uji biokimia dengan MRPV, TSIA, SIM, uji koagulase dan uji gula – gula . Hasil penelitian menunjukkan 23 sampel (tiga belas dari babi pra sapih dan sepuluh dari babi pasca sapih) telah terdeteksi positif Streptococcus sp. ? hemolitik (20 isolat) dan Streptococcus sp. ? hemolitik (3 isolat).