bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceived Learning Outcomes and Team Behavior in Entrepreneurial Venture Creation Universitas Ciputra Surabaya 2020
Authors: Indudewi Yuanita Ratna 
Published: June 2021

<p><em>Entrepreneurial Venture Creation is one of signature curricula in International Business Management Universitas Ciputra Surabaya. It is part of 7 semesters Entrepreneurship Education Journey to equip students with entrepreneurial skill by doing real business project. It is a set skill that helps students to face volatile, uncertain, complex and ambiguous (VUCA) future. Especially during COVID-19, it’s one of a real case study of VUCA. During Entrepreneurial Venture Creation (EVC), students guided through design thinking phase starting from empathize, defining problem, ideation and prototyping, market testing, finally they evaluate and conclude their venture development. Half of the design thinking process of EVC was done remotely in an online classroom platform due to COVID-19. The purpose of this research is to evaluate whether Entrepreneurship Education intervention in form of Entrepreneurial Venture Creation curricula can increase their perceived knowledge, perceived entrepreneurial mindset, and perceived venture creation skill. This study also want get a closer understanding how team behavior can interfere their venture continuation. There are 533 of second semester students who were participated in the survey. Total population sampling was used in the process. The result of simple statistic descriptive showed they have positively increased their perceived entrepreneurial knowledge, perceived entrepreneurial mindset and perceived venture creation skill, whether they have a good team behavior or not. The statistic showed that there are 9.19% teams that didn’t have good behavior and decided to discontinue their venture, yet still have high perceived entrepreneurial knowledge, perceived entrepreneurial mindset, and perceived venture creation skill.</em></p>
EFEKTIVITAS MEDIA SOSIAL DALAM PENYEBARLUASAN INFORMASI PEMBANGUNAN PEMERINTAH KABUPATEN BANYUASIN
Authors: Farid Muhammad Mifta , Revaldo Muhammad Ari 
Published: June 2021

<p>Pembangunan yang dilakukan oleh pemerintah seringkali tidak diketahui oleh masyarakat Kabupaten Banyuasin secara luas, karena lambatnya proses penyampaian informasi, seringkali informasi pembangunan yang dilakukan hanya diketahui oleh instansi-instansi Pemerintah yang terkait dan masyarakat lokal tempat kegiatan pembangunan dilakukan. Selain itu, penggunaan akun-akun media sosial resmi pemerintah yang belum maksimal menyebabkan masyarakat Kabupaten Banyuasin masih banyak yang belum mengetahui bahwa pemerintah sudah memiliki akun media sosial resmi yang digunakan untuk memberikan informasi-informasi mengenai kegiatan pembangunan yang dilakukan oleh Pemerintah di Kabupaten Banyuasin. Penelitian yang dilakukan bertujuan untuk mengetahui bagaimana efektivitas media sosial dalam penyebarluasan informasi pembangunan Pemerintah Kabupaten Banyuasin. Metode yang digunakan dalam penelitian ini yakni menggunaan metode deskriptif kualitatif, dengan menggunakan teknik pengumpulan data melalui observasi, wawancara dan dokumentasi. Sumber data primer dalam penelitian ini adalah admin media sosial resmi pemerintah, sedangkan sumber data sekunder dalam penelitian ini yaitu berupa dokumen, struktur organisasi dan buku-buku yang berkaitan dengan penelitian. Hasil yang didapat dari penelitian yang dilakukan berdasarkan indikator dari <em>Teori Uses and Effect</em> yaitu, Efek yang didapat ialah penyebaran dan penerimaan informasi dari Pemerintah Kabupaten Banyuasin kepada masyarakat terjadi secara efektif dan efisien, kemudian Konsekuensi yang didapat ialah informasi terbaru yang dibagikan oleh Pemerintah Kabupaten Banyuasin dapat langsung diakses oleh masyarakat, serta Konsefek yang didapat ialah Pemerintah Kabupaten Banyuasin mendapatkan kepercayaan yang tinggi dari masyarakat atas informasi-informasi yang dibagikan melalui media sosial resmi milik Pemerintah Kabupaten Banyuasin.</p><p> </p>
Impact of Encapsulation on Plantlet Regeneration from in vitro Grown Shoot tips of Citrus aurantifolia (Lime)
Authors: Sharma Priyanka , Roy Bidhan 
Published: June 2021

In order to conserve diverse species of citrus, an experiment on in vitro micropropagation and production of synthetic seeds from in vitro regenerated plant propagules of the species; Citrus aurantifolia (Lime) was carried out in which shoot tips were found to be suitable for excapsulation of artificial seeds. Highest rate of germination was obtained from the shoot tips when MS was supplemented with 1 mg/l BAP. Beaded shoot tips produced maximum germination (81.43%). Germinated synthetic seeds with well established roots and shoots were were taken out from the culture bottles and transferred in plastic cups containing a mixture of sterile soil: sand and farmyard manure at a ratio of 1:1:1. Seedlings were further shifted in earthen pots and kept in a partial shed net house for 7 days. Those seedlings were finally transferred under the field conditions for acclimatization.
Plant Tissue Cult. & Biotech. 31(1): 43-49, 2021 (June)
Mass Propagation of Nauclea diderrichii (de Willd. & Th. Dur) Merr. Seedlings through Tissue Culture Technique
Authors: Oyediran RI , Afolabi JO , Olomola DB , Akanni FO 
Published: June 2021

Nauclea diderrichii is a tree species of economic importance. However, its plantation establishment is limited by inadequate seedling production. Hence, there is ample scope of tissue culture for its mass propagation. Its in vitro plantlets development as affected by media strengths indicated that 100 % seed germination was obtained in full MS basal medium while the least (3.35 %) was from quarter-strength at 8 Weeks after inoculation (WAI). The effects of BAP and NAA assessed on the growth of its sub-cultured plantlets showed that highest number of leaves (17) and adventitious shoots (3) were obtained from MS basal medium supplemented with 0.1 mg/l BAP only. Whereas, highest shoot length (3.61 cm) and average number of roots (5/plantlet) were obtained from the same medium without hormone(s) at 8 WAI. Further sub-culturing into MS with 0.05 mg/l NAA resulted into plantlets having optimum shoot and massive root growth ready for acclimatization in 6 WAI. The plantlets were successfully acclimatized using coconuthusk/ topsoil mixture with 90 % survival.
Plant Tissue Cult. & Biotech. 31(1): 51-60, 2021 (June)
Assessing the effect of decopmression surgery performed due to malignant ischemic stroke on the quality of life
Authors: ŞİMŞEK Fatma , BİLGE Nuray , KOÇAK Mehmet Nuri , CEYLAN Mustafa , EREN Alper , YEVGİ Recep , KARAAVCI Nuh Çağrı 
Published: June 2021

Aim: Decompressive craniectomy is one of the treatment methods that reduces mortality, when used in eligible patients for the treatment of malignant ischemic stroke (MIS). In this study, weaimed to assess the effect of age and the timing of surgery on the quality of life and on the prognosis of patients that underwent decompressive craniectomy.Material and Method: The files of 45 patients between the ages of 24-98, who were recommended decompressive craniectomy in connection with malignant ischemic stroke, were reviewed within the scope of the study. Result: 27 (60%) patients, who agreed to undergoing surgery, and 18 (40%) patients, who did not agree to undergoing surgery, were taken under review. A significant improvement (between 0 and 3) was observed in the modified Rankin Scale Scores of the two patients that underwent surgery. All the patients (n = 4) from within the group of patients that did not agree to a surgery, who lived for more than 6 months, were found to have a modified Rankin Scale Score of 5 and needed support to fulfill their daily life activities. Conclusion: It has been observed that performing a decompressive craniectomy after 72 hours following clinical deterioration and radiological shift did not have a significant effect on mortality and morbidity. Studies with larger patient groups are needed to be carried out in order to determine the applicability criteria of surgical treatment.
Daya Terima Konsumen Dan Sifat Fisik Roti Soft Roll Substitusi Tepung Hanjeli (C. Lacryma-jobi L.)
Authors: Irwan Irwan , Dahlia Mutiara , Ruslianti Rusilanti 
Published: June 2021

ABSTRACT The aim of this research was to analyze the effect of job’s tear flour substitution in bread making on the consumer’s acceptance based on external (volume, crust’s color, form’s symmetry, bake’s evenness, crust characteristic) internal (grain, crumb’s color, aroma, flavor, texture) characteristics and physical characteristics (volume, growth power ratio). This research used experimental method. The sample of this research was soft roll with job’s tear substitution 10%, 20%, and 30% amount of percentages. Data collection technique used was acceptance test hedonic scale by 25 unskill panelists. The result of hedonic test indicated that soft roll with 10% job’s tear flour substitution was the most preferred on internal characteristics and soft roll with 20% job’s tear flour substitution was the most preferred on external characteristics. Friedman test with significant level α=0.05 showed that job’s tear flour substitution had effects on volume, crust’s color, crust characteristic, grain, aroma, flavor, and texture on soft roll. Tuckey’s test result showed that job’s tear flour substitution as much 10% was the most preferred and was recommended to be developed. Physical characteristics valuation showed that soft roll with 10% job’s tear flour substitution had bigger volume and growth power ratio than the other samples. ABSTRAKPenelitian ini dilakukan untuk mengetahui pengaruh substitusi tepung hanjeli dalam pembuatan roti soft roll terhadap daya terima konsumen pada aspek eksternal (volume, warna kulit roti, bentuk, keseragaman pemanggangan, karakter kulit roti) aspek internal (pori-pori roti, warna crumb, aroma, rasa, tekstur) dan sifat fisik roti (volume roti, rasio pengembangan). Penelitian ini menggunakan metode ekperimen. Sampel dalam penelitian ini adalah roti soft roll substitusi tepung hanjeli dengan persentase 10%, 20%, dan 30%. Teknik pengumpulan data yang digunakan adalah tes kesukaan oleh 25 panelis tidak terlatih. Hasil tes kesukaan menunjukan roti soft roll substitusi tepung hanjeli 10% merupakan produk yang paling disukai pada aspek internal dengan rentan nilai 4,00 hingga 4,24 dan roti soft roll substitusi tepung hanjeli 20% merupakan produk yang paling disukai pada hampir semua aspek eksternal dengan rentan nilai 4,24 hingga 4,40. Berdasarkan hasil uji Friedman dengan perbedaan signifikan α=0,05 menyatakan terdapat pengaruh substitusi tepung pada aspek volume, warna kulit roti, karakter kulit roti, pori-pori roti, aroma, rasa hanjeli, dan tekstur. Hasil uji Tuckey menunjukan bahwa roti soft roll substitusi tepung hanjeli 10% adalah yang disukai konsumen, sehingga direkomendasikan untuk dikembangkan. Penilaian fisik menunjukkan roti soft roll substitusi tepung hanjeli 10% memiliki volume dan rasio pengembangan terbesar dibandingkan sampel lainnya.
In Vivo Behavior of the Antibacterial Peptide Cyclo[RRRWFW], Explored Using a 3-Hydroxychromone-Derived Fluorescent Amino Acid
Authors: Afonin Sergii , Koniev Serhii , Préau Laetitia , Takamiya Masanari , Strizhak Alexander V. , Babii Oleg , Hrebonkin Andrii , Pivovarenko Vasyl G. , Dathe Margitta , le Noble Ferdinand , Rastegar Sepand , Strähle Uwe , Ulrich Anne S. , Komarov Igor V. 
Published: June 2021

Labeling biomolecules with fluorescent labels is an established tool for structural, biochemical, and biophysical studies; however, it remains underused for small peptides. In this work, an amino acid bearing a 3-hydroxychromone fluorophore, 2-amino-3-(2-(furan-2-yl)-3-hydroxy-4-oxo-4H-chromen-6-yl)propanoic acid (FHC), was incorporated in a known hexameric antimicrobial peptide, cyclo[RRRWFW] (cWFW), in place of aromatic residues. Circular dichroism spectropolarimetry and antibacterial activity measurements demonstrated that the FHC residue perturbs the peptide structure depending on labeling position but does not modify the activity of cWFW significantly. FHC thus can be considered an adequate label for studies of the parent peptide. Several analytical and imaging techniques were used to establish the activity of the obtained labeled cWFW analogues toward animal cells and to study the behavior of the peptides in a multicellular organism. The 3-hydroxychromone fluorophore can undergo excited-state intramolecular proton transfer (ESIPT), resulting in double-band emission from its two tautomeric forms. This feature allowed us to get insights into conformational equilibria of the labeled peptides, localize the cWFW analogues in human cells (HeLa and HEK293) and zebrafish embryos, and assess the polarity of the local environment around the label by confocal fluorescence microscopy. We found that the labeled peptides efficiently penetrated cancerous cells and localized mainly in lipid-containing and/or other nonpolar subcellular compartments. In the zebrafish embryo, the peptides remained in the bloodstream upon injection into the cardinal vein, presumably adhering to lipoproteins and/or microvesicles. They did not diffuse into any tissue to a significant extent during the first 3 h after administration. This study demonstrated the utility of fluorescent labeling by double-emission labels to evaluate biologically active peptides as potential drug candidates in vivo.
Congenital Asplenia Interrupts Immune Homeostasis and Leads to Excessive Systemic Inflammation in Zebrafish
Authors: Xie Lang , Chen Zheyu , Guo Hui , Tao Yixi , Miao Xiaomin , Wu Ronghua , Li Yun 
Published: June 2021

Splenectomy or congenital asplenia in humans increases susceptibility to infections. We have previously reported that congenital asplenia in zebrafish reduces resistance to Aeromonas hydrophila infection. However, the molecular mechanism of systemic immune response in congenitally asplenic individuals is largely unexplored. In this study, we found that pro-inflammatory cytokines were more highly induced in congenitally asplenic zebrafish than wild-type after pathogenic A. hydrophila infection and lipopolysaccharide exposure. In addition, a higher aggregation of apoptotic cells was observed in congenitally asplenic zebrafish than that in wild-type. Next, we examined the transcriptome profiles of whole kidneys from wild-type and congenitally asplenic zebrafish to investigate the effects of congenital asplenia on innate and adaptive immune responses induced by the inactivated A. hydrophila. Congenital asplenia inactivated the splenic anti-inflammatory reflex, disrupted immune homeostasis, and induced excessive inflammation as evidenced by the highly induced stress response–related biological processes, inflammatory and apoptosis-associated pathways, and pro-inflammatory cytokines/chemokines in congenitally asplenic zebrafish compared with wild-type after vaccination. In addition, complement component genes (c3a.1, c3a.6, c4, c6, and c9) and several important immune-related genes (tabp.1, tap1, hamp, prg4b, nfil3, defbl1, psmb9a, tfr1a, and sae1) were downregulated in congenitally asplenic zebrafish. Furthermore, congenital asplenia impaired adaptive immunity as demonstrated by downregulation of biological processes and signaling pathways involved in adaptive immune response after vaccination in congenitally asplenic zebrafish. The expression of MHCII/IgM was also significantly reduced in the congenitally asplenic zebrafish when compared with wild-type. Together, our study provides an in-depth understanding of spleen function in controlling immune homeostasis and may offer insight into the pathological response in splenectomized or congenitally asplenic patients after infections.
Nutraceutical Approach to Preventing Coronavirus Disease 2019 and Related Complications
Authors: Derosa Giuseppe , Maffioli Pamela , D’Angelo Angela , Di Pierro Francesco 
Published: June 2021

IntroductionSeveral months ago, Chinese authorities identified an atypical pneumonia in Wuhan city, province of Hubei (China) caused by a novel coronavirus (2019-nCoV or SARS-CoV-2). The WHO announced this new disease was to be known as “COVID-19”.Evidence AcquisitionSeveral approaches are currently underway for the treatment of this disease, but a specific cure remains to be established.Evidence SynthesisThis review will describe how the use of selected nutraceuticals could be helpful, in addition to pharmacological therapy, in preventing some COVID-19-related complications in infected patients.ConclusionsEven if a specific and effective cure for COVID-19 still has some way to go, selected nutraceuticals could be helpful, in addition to pharmacological therapy, in preventing some COVID-19-related complications in infected patients.
A Retrospective, Multicenter, Long-Term Follow-Up Analysis of the Prognostic Characteristics of Recurring Non-Metastatic Renal Cell Carcinoma After Partial or Radical Nephrectomy
Authors: Kim Sung Han , Park Boram , Hwang Eu Chang , Hong Sung-Hoo , Jeong Chang Wook , Kwak Cheol , Byun Seok Soo , Chung Jinsoo 
Published: June 2021

This study aimed to compare the cancer-specific survival (CSS) and overall survival (OS) of nephrectomized patients with non-metastatic renal cell carcinoma (nmRCC) and local recurrence without distant metastasis (LR group), those with metastasis without local recurrence (MET group), and those with both local recurrence and metastasis (BOTH group). This retrospective multicenter study included 464 curatively nephrectomized patients with nmRCC and disease recurrence between 2000 and 2012; the follow-up period was until 2017. After adjusting for significant clinicopathological factors using Cox proportional hazard models, CSS and OS were compared between the MET (n = 50, 10.7%), BOTH (n = 95, 20.5%), and LR (n = 319, 68.8%) groups. The CSS and OS rates were 34.7 and 6.5% after a median follow-up of 43.9 months, respectively. After adjusting for significant prognostic factors of OS and CSS, the MET group had hazard ratios (HRs) of 0.51 and 0.57 for OS and CSS (p = 0.039 and 0.103), respectively, whereas the BOTH group had HRs of 0.51 and 0.60 for OS and CSS (p &lt; 0.05), respectively; LR was taken as a reference. The 2-year OS and CSS rates from the date of nephrectomy and disease recurrence were 86.9% and 88.9% and 63.5% and 67.8%, respectively, for the LR group; 89.5% and 89.5% and 48.06% and 52.43%, respectively, for the MET group; and 96.8% and 96.8% and 86.6% and 82.6%, respectively, for the BOTH group. Only the LR and BOTH groups had significant differences in the 2-year OS and CSS rates (p &lt; 0.05). In conclusion, our study showed that the LR group had worse survival prognoses than any other group in nephrectomized patients with nmRCC.
Case Report: Low-Dose Apatinib in the Treatment of Intrahepatic Biliary Cystadenoma With Recurrence and Malignant Transformation
Authors: Yang Yongguang , Mai Weiheng , Chen Weifeng , Yang Chao , Li Mingyi , Liu Lijuan 
Published: June 2021

Apatinib is a new oral tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor-2. It has been proven effective in treating multiple solid tumors. Herein, we report the case of a 67-year-old Chinese patient who was diagnosed with recurrent and malignant transformation of intrahepatic biliary cystadenoma. After multidisciplinary team discussion, the team considered that the remaining liver volume was insufficient for surgical resection. The patient refused chemotherapy and radiotherapy and was willing to take apatinib. Initially, the patient experienced severe tongue ulcers and difficulty eating. The dose of apatinib was then adjusted to 250 mg/day. To date, he has been taking apatinib for 48 months. Regular re-examination showed that the tumor had significantly decreased in size. On January 16, 2021, a CT scan revealed a tumor diameter of 4.5 cm. In our case, the patient achieved partial response and progression-free survival(PFS) of 48.0 months. During treatment, the patient’s appetite and mental state were expected. The treatment did not induce hypertension, fatigue, hand-foot syndrome, or liver and kidney damage. Apatinib may be an option for the treatment of advanced intrahepatic biliary cystadenocarcinoma. Its toxicity is controllable and tolerable. The exact curative effect still needs to be evaluated in more cases.
Components and Pharmacodynamical Mechanism of Yinfupian Based on Liquid Chromatography-Mass Spectrometry and Proteomics Analyses
Authors: Tong Heng-li , Chen Hao , Gong Fei-peng , Zhong Ling-yun , Zhu Jing , Yang Song-hong 
Published: June 2021

Objective: According to the treatment records of Yang deficiency syndrome (YDS) with characteristic decoction pieces of lateral root of Aconitum carmichaelii—Yinfupian (YF) in traditional Chinese medicine prepare school, known as “Jianchangbang”. The aim of this study was to investigate differences in the composition and therapeutic mechanism of the unprocessed lateral root of Aconitum carmichaelii (ULRA) and its processed product (YF).Methods: Ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry and orthogonal partial least squares discriminant analysis method were used to determine and screen the main components of ULRA and YF. Changes in the histological structure and morphology of gonads in rats were observed using hematoxylin-eosin. Enzyme-linked immunosorbent assay was used to determine the contents of serum cyclic adenosine monophosphate and cyclic guanosine monophosphate in YDS rats treated with ULRA and YF. Tandem mass tag proteomics analysis was used to identify the differentially expressed proteins in YDS rats treated with ULRA and YF.Results: Both ULRA and YF exerted certain therapeutic effects on rats with YDS. They improved the gonadal morphology and increased the contents of serum cyclic adenosine monophosphate and cyclic guanosine monophosphate. After processing of ULRA into YF, the content of C19-diester-diterpenoid alkaloids decreased (converted into C19-monoester-diterpenoid alkaloids and C19-alkylol amine-diterpenoid alkaloids), whereas that of C20-diterpene alkaloids increased. Proteomics analysis showed that cytochrome P450 and aldehyde oxidase 3 (AOX3) were downregulated, whereas cathepsin G (CTSG) was upregulated in rats with YDS. Treatment with ULRA mainly downregulated the expression of α-actinin, fast skeletal troponin, creatine kinase, and myosin. Treatment with YF mainly upregulated the expression of mitochondrial ribosomal protein and mitochondrial inner membrane protein.Conclusion: ULRA and YF exerted good therapeutic effects on YDS; the main difference in components between these preparations was in C19-diterpenoid alkaloids. ULRA mainly acts on the muscle contraction-related proteins and is closely related to inflammation and myocardial injury. YF mainly acts on the mitochondrial proteins and is closely related to adenosine triphosphate energy metabolism.