bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance and Hemocompatibility of a Novel Polysulfone Dialyzer: A Randomized Controlled Trial
Authors: Ehlerding Götz , Erlenkötter Ansgar , Gauly Adelheid , Griesshaber Bettina , Kennedy James , Rauber Lena , Ries Wolfgang , Schmidt-Gürtler Hans , Stauss-Grabo Manuela , Wagner Stephan , Zawada Adam M. , Zschätzsch Sebastian , Kempkes-Koch Manuela 
Published: April 2021

Abstract

Key Points

We investigated the performance and hemocompatibility of a new polysulfone hemodialyzer with enhanced membrane properties.β2-Microglobulin removal rate was noninferior to both comparator dialyzers and superior to a cellulose-acetate–based dialyzer.The dialyzer showed a favorable hemocompatibility profile on the basis of markers for complement, cell and contact activation, and coagulation.

Background
High-flux dialyzers effectively remove uremic toxins, are hemocompatible to minimize intradialytic humoral and cellular stimulation, and have long-term effects on patient outcomes. A new dialyzer with a modified membrane surface has been tested for performance and hemocompatibility.

Methods
This multicenter, prospective, randomized, crossover study involved the application of the new polysulfone-based FX CorAL 600 (Fresenius Medical Care, Bad Homburg, Germany), the polyarylethersulfone-based Polyflux 170H (Baxter Healthcare Corporation, Deerfield, IL), and the cellulose triacetate–based SureFlux 17UX (Nipro Medical Europe, Mechelen, Belgium), for 1 week each, to assess the noninferiority of the FX CorAL 600’s removal rate of β2-microglobulin. Performance was assessed by removal rate and clearance of small- and medium-sized molecules. Hemocompatibility was assessed through markers of complement, cell activation, contact activation, and coagulation.

Results
Of 70 patients, 58 composed the intention-to-treat population. The FX CorAL 600’s removal rate of β2-microglobulin was noninferior to both comparators (P<0.001 versus SureFlux 17UX; P=0.0006 versus Polyflux 170H), and superior to the SureFlux 17UX. The activation of C3a and C5a with FX CorAL 600 was significantly lower 15 minutes after treatment start than with SureFlux 17UX. The activation of sC5b-9 with FX CorAL 600 was significantly lower over the whole treatment than with SureFlux 17UX, and lower after 60 minutes than with the Polyflux 170H. The treatments with FX CorAL 600 were well tolerated.

Conclusions
FX CorAL 600 efficiently removed small- and medium-sized molecules, showed a favorable hemocompatibility profile, and was associated with a low frequency of adverse events in this study, with a limited patient number and follow-up time. Further studies, with longer observation times, are warranted to provide further evidence supporting the use of the new dialyzer in a wide range of therapeutic options, and for long-term treatment of patients on hemodialysis, to minimize the potential effects on inflammatory processes.
Akibat Hukum Putusan Pra Peradilan Terhadap Penetapan Tersangka Dugaan Melakukan Tindak Pidana Korupsi Di Sekretariat DPRD Tulang Bawang
Authors: Rahmawati Ismi , Hartono Bambang , Hasan Zainudin 
Published: April 2021

Salah satu perkara pengajuan pra peradilan terhadap penetapan tersangka dugaan melakukan tindak pidana korupsi adalah Putusan Nomor: 6/Pid.Pra/2020/PN.Tjk, dimana pada putusan tersebut menyatakan bahwa berdasarkan pertimbangan-pertimbangan tersebut diatas, Hakim berkesimpulan bahwa tindakan tindakan Termohon yang menetapkan Pemohon sebagai Tersangka karena adanya penyimpangan pengeluaran anggaran Sekretariat DPRD Kabupaten Tulang Bawang Tahun Anggaran 2018-2019 telah sesuai peraturan perundang undangan, sehingga Surat Penetapan Tersangka Nomor S.Tap/03/VI/2020/ Ditreskrimsus tertanggal 23 Juni 2020 terhadap Pemohon adalah sah dan mempunyai kekuatan hukum mengikat. Memperhatikan Pasal 77 Undang-undang Nomor 8 Tahun 1981 tentang Hukum Acara Pidana, Putusan Mahkamah Konstitusi Nomor 21/PUU-XII/2014 tertanggal 28 April 2015 dan Peraturan Mahkamah Agung RI Nomor 4 Tahun 2016 serta peraturan perundang-undangan lain yang bersangkutan serta Menolak permohonan praperadilan Pemohon untuk seluruhnya. Permasalahan penelitian ini adalah: Bagaimana proses penyidikan tindak pidana korupsi Sekretariat DPRD Tulang Bawang oleh Polda Lampung, Apakah dasar pertimbangan hakim Pengadilan Negeri Tanjung Karang dalam putusan Nomor: 6/Pid.Pra/2020/PN.Tjk yang menolak permohonan pra peradilan tersangka? dan Apa akibat hukum dari Putusan Pra peradilan Nomor: 6/Pid.Pra/2020/PN.Tjk. Metode penelitian menggunakan pendekatan yuridis normatif dan empiris. Jenis data yang digunakan adalah data sekunder dan data primer. Pengumpulan data melalui penelitian kepustakaan (library research) dan penelitian lapangan (field research). Analisis data yang digunakan adalah yuridis kualitatif
Aerosol Jet Direct Writing Polymer-Thick-Film Resistors for Printed Electronics
Authors: Feng James , Loveland Anthony , Renn Michael 
Published: April 2021

To improve performance and reduce size of printed-circuit board (PCB) in electronics industry, embedding discrete components within a board substrate has been an effective approach by reducing solder joints and their associated impedance mismatching, inductive reactance, etc. With its unique capabilities for non-contact precision material deposition, the Aerosol Jet® direct-write technology has been enabling additive manufacturing of fine-feature electronics conformally onto flexible substrates of complicated shapes. The CAD/CAM controlled relative motions between substrate and print head allows convenient adjustment of the pattern and pile height of deposited material at a given ink volumetric deposition rate. To date in the printed electronics industry, additively printing embedded polymer-thick-film (PTF) resistors has mostly been done with screen printing using carbon-based paste inks. Here we demonstrate results of Aerosol Jet® printed PTF resistors of resistance values ranging from ~50 W to > 1 kW, adjustable (among several variable parameters) by the number of stacked layers (or print passes with each pass depositing a fixed amount of ink) between contact pads of around 1 mm apart with footprint line typically < 0.3 mm. In principle, any ink material that can be atomized into fine droplets of 1 to 5 microns can be printed with the Aerosol Jet® system. However, the print quality such as line edge cleanliness can significantly influenced by ink rheology which involves solvent volatility, solids loading, and so on. Our atomizable carbon ink was made by simply diluting a screen printing paste with a compatible solvent of reasonable volatility, which can be cured at temperatures below 200 oC. We show that Aerosol Jet® printed overlapping lines can be stacked to large pile height (to reduce the resistance value) without significant increase of line width, which enables fabricating embedded resistors with adjustable resistance values in a limited footprint space.
PENGARUH UPAH MINIMUM TERHADAP TINGKAT PRODUKTIVITAS KERJA PT. TELKOM CABANG BOGOR
Authors: Ardista Rini 
Published: April 2021

This research aims to determine whether the minimum wage is related to the level of work productivity of the production department at PT. TELKOM CABANG BOGOR, to find out whether the minimum wage affects the work productivity of the employees of PT. TELKOM CABANG BOGOR.
The sample used was 100 respondents taken by accidental sampling technique in the PT. TELKOM CABANG BOGOR. This research uses simple linear regression. A tool to measure it is assisted by SPSS version 22.
The results of the linearity test of the effect of the minimum wage on work productivity, there is a significance value of 0.115 which is greater than 0.05, so there is a linear relationship. The results of the t test show that the minimum wage has a significance level of 0.115 and the t value of 3.345> t table of 1.984 is greater than 0.05. From the results of the F test it can also be concluded that the F-table at df1 = 2 df2 = 97 is obtained from the F distribution table of 3.09 at the 95% confidence level (Alpha = 5%). This proves that Fcount (88,986)> from Ftable (3.09), while the significance (0,000) <from alpha is at the 95% confidence level (Alpha 5%). So that Ha which says there is a significant influence between the minimum wage on the work productivity of the production section at PT. TELKOM CABANG BOGOR accepted. While Ho, which says there is no significant effect between minimum wages on work productivity at PT. TELKOM CABANG BOGOR rejected.
PENGARUH CITRA MEREK DAN KUALITAS PRODUK TERHADAP MINAT BELI SEPATU ANDO (STUDI KASUS DI KOTA BEKASI 2020)
Authors: Marpaung Netti Natarida 
Published: April 2021

The purpose of this research was to determine the effect and relationship of variable Brand Image and Product Quality partially and simultaneously on the Interest in Buying Ando Shoes products of PT. Halim Jaya Sakti in Sidoarjo. The method used is to use quantitative data by distributing questionnaires as many as 95 respondents. This research data uses primary data. Sampling analysis tools used are validity test, reliability test, correlation test, classic assumption test, simple linear regression test, t test (partial), F test (simultaneous), and coefficient of determination test using SPSS software version 21.0.
Based on the results of this study indicate that the variable Brand Image is quite influential and related which shows a positive and significant direction to the Purchase Interest of Ando Shoes products at Pt. Halim Jaya Sakti in Sidoarjo. Proven in the t test, the Brand Image variable t value> t table is (96.777> 1.66140) and Product Quality variable t value> t table is (108.432> 1.66140) so the correlation test calculation is more significance value smaller than the 0.05 significant level that is equal to 0,000 <0.05.
A trajetória do arquiteto Roberto Capello: Turim e Brasil
Authors: De Arimateia Karine , Maria Gadelha Albano Amora Ana 
Published: April 2021

Este artigo insere-se no campo de estudos relativos à produção arquitetônica dos profissionais pouco referenciados na literatura brasileira, referente às primeiras décadas do século XX. Para tanto, apresenta a trajetória do arquiteto italiano Roberto Capello, que migrou para o Brasil na década de 1930 para trabalhar na empresa Sul América, onde assinou os projetos para as sedes nas principais capitais brasileiras. Tal apresentação foi extraída da pesquisa pessoal de doutoramento em curso no Proarq/UFRJ, cujo objetivo é, a partir do estudo referenciado dessas obras, apreender o cenário constituinte do processo de transformação da arquitetura brasileira do período de 1930 a 1950.
Le poids économique direct de la culture en 2019
Authors: Turner Laure 
Published: April 2021

En 2019, le poids économique direct de la culture, c’est-à-dire la valeur ajoutée de l’ensemble des branches culturelles, est de 49,2 milliards d’euros. La part de la culture dans l’ensemble de l’économie s’établit ainsi à 2,3 %, soit un poids stable depuis 2013. Le recul des branches du livre, et plus particulièrement de la presse, continue de peser sur la croissance. À l’inverse, l’audiovisuel, première branche culturelle en termes de poids économique (28 % de la valeur ajoutée de l’ensemble des branches culturelles), les arts visuels et le patrimoine soutiennent la croissance de la valeur ajoutée de la culture. En 2019, le poids de la branche du spectacle vivant (15 % de l’ensemble des branches culturelles) dépasse pour la première fois celui de la presse et du livre (14 %). En 2018, 692 900 personnes travaillent dans les secteurs culturels (2,6 % de la population active), principalement dans le livre et la presse (19 %), les arts visuels (15 %) et l’audiovisuel (15 %). Un tiers des actifs des secteurs culturels sont indépendants, contre seulement 12 % dans la population active de l’ensemble des secteurs.
Qu’est-ce que l’analyse militante apporte à l’évaluation des politiques publiques ?
Authors: Tevini Marc 
Published: April 2021

Cet article s’intéresse au rapprochement entre l’évaluation des politiques publiques et certaines analyses conduites par des organisations militantes. Il étudie des travaux militants qui s’appuient, comme les évaluations, sur la collecte de données probantes afin de juger de l’efficacité, de la cohérence et de la pertinence de certaines politiques publiques. Alors que ces travaux ne portent pas toujours le nom ni ne se réfèrent à l’évaluation des politiques publiques, deux études de cas permettent d’illustrer et de documenter la façon dont ces démarches mobilisent des informations à caractère évaluatif dans une logique de plaidoyer. Ces travaux qui visent à alerter l’opinion publique via une approche se voulant évaluative seraient-ils plus à même de susciter la controverse et le débat public ?
Évaluer la formation professionnelle continue : le paritarisme à l’épreuve
Authors: Gassert Edine 
Published: April 2021

Cet article interroge le processus d’institutionnalisation de l’évaluation qui s’est enclenché au cours de la dernière décennie au sein du régime paritaire de la formation professionnelle. Tout d’abord, il montre comment l’évaluation est devenue un enjeu politique. Il explore ensuite la mise en forme de l’évaluation au prisme des rapports sociaux et des arrangements institutionnels issus d’une réforme intervenue en 2009. Enfin, il explore les retombées du « travail d’évaluation » sur les acteurs syndicaux. À travers l’examen des dynamiques d’apprentissage et des obstacles reliés à la pratique de l’évaluation, l’article met en lumière les ressorts de la constitution d’un nouvel acteur collectif de l’évaluation dans le domaine de l’action publique négociée de la formation professionnelle.
Regulation of Anion Channel LRRC8 Volume-Regulated Anion Channels in Transport of 2′3′-Cyclic GMP–AMP and Cisplatin under Steady State and Inflammation
Authors: Chen Xia , Wang Li , Cao Limin , Li Tiantian , Li Zhihong , Sun Yumeng , Ding Jinqiu , Zhou Chun , Xie Yadong , Yue Nan , Nan Jing , Jia Xin-Ming , Peng Chao , Li Huabin , Yang Jinbo , Xiao Hui 
Published: April 2021

AbstractThe recently identified anion channel LRRC8 volume-regulated anion channels (VRACs) are heteromeric hexamers constituted with the obligate LRRC8A subunit paired with at least one of the accessory LRRC8B to LRRC8E subunits. In addition to transport chloride, taurine, and glutamate, LRRC8 VRACs also transport the anticancer agent cisplatin and STING agonists 2′3′-cyclic GMP–AMP (cGAMP) and cyclic dinucleotides; hence, they are implicated in a variety of physiological and pathological processes, such as cell swelling, stroke, cancer, and viral infection. Although the subunit composition largely determines VRAC substrate specificity, the opening of various VRAC pores under physiological and pathological settings remains enigmatic. In this study, we demonstrated that VRACs comprising LRRC8A and LRRC8E (LRRC8A/E–containing VRACs), specialized in cGAMP transport, can be opened by a protein component present in serum under resting condition. Serum depletion ablated the tonic activity of LRRC8A/E–containing VRACs, decreasing cGAMP transport in various human and murine cells. Also, heating or proteinase K treatment abolished the ability of serum to activate VRAC. Genetic analyses revealed a crucial role for cGAMP synthase (cGAS) in serum/TNF–promoted VRAC activation. Notably, the presence of cGAS on the plasma membrane, rather than its DNA-binding or enzymatic activity, enabled VRAC activation. Moreover, phospholipid PIP2 seemed to be instrumental in the membrane localization of cGAS and its association with VRACs. Corroborating a role for LRRC8A/D–containing VRACs in cisplatin transport, serum and TNF markedly potentiated cisplatin uptake and killing of cancer cells derived from human or mouse. Together, these observations provide new insights into the complex regulation of VRAC activation and suggest a novel approach to enhance the efficacy of cGAMP and cisplatin in treating infection and cancer.
Ethanol production from corn husk, coconut husk and plantain peel using Saccharomyces cereviasae
Authors: Olorode E.M. , Aderibigbe D.B. , Oloyede O.E. , Omidiran M.B. , Kolawole I. , Musa F.B. 
Published: April 2021

Corn Husk (CH), Coconut Husk (CCH) and Plantain Peel (PP) used for this work are agricultural wastes sourced from local end users. These waste biomasses were subjected to simple physical treatment of particle size reduction and used for anaerobic fermentativeproduction of alcohol. The biomass and media were added in ratio 1:20 (w/v) in 250 ml flask, incubated at 30 oC for 24 h. Aliquots from the Fermented slurry were withdrawn from the flasks and tested for ethanol produced at interval of 3 h for the 24 h period. Ethanolproduction performance occurred in the order PP > CH >CCH with 5.06, 4.69 and 4.63 g/L respectively. These values are less than 6.75 g/L recorded in pure glucose used as control. These results show the possibility of the utilization of agricultural waste for ethanolproduction. Intensification of the pretreatment technique and combination of different pretreatments could enhance higher ethanol production from agricultural wastes and biomass.
Keywords: Ethanol, Pretreatment, Agricultural wastes, fermentation,
Facilitation of nursing students' competency acquisition for paediatric pain management in low- and middle-income countries: a scoping review
Authors: Uwimana P. , Mukamana D. , Adejumo O. , Babenko-Mould Y. , Umubyeyi B. 
Published: April 2021

Objective: To elucidate evidence regarding nurse educators' and preceptors' capacity to facilitate students' learning about paediatric pain management (PPM) in low- and middle-income countries(LMICs).Methods: The five-stage framework by Arksey and O'Malley guided this review. Studies published in English between January 2010 and April 2020 were searched using EBSCO Host/ ScienceDirect, CINAHL, MEDLINE, PUBMED and Scopus. Of 300 papers identified through the search strategy 27 primary research articles were retained: quantitative (n=18), qualitative (n=8) and mixed-methods (n=1).Results: Knowledge deficiency and inappropriate attitudes toward PPM, lack of autonomy in decisionmaking, scarcity of resources and cultural misconception regarding pain in children were hindering the effective PPM in LMICs. Strategies including nursing curricula review, continuous in-service training, access to resources and the leadership support are required to optimise effective PPM and improve students' facilitation for learning about PPM.Conclusion: Further research is required as a body of evidence to support the development of a framework for capacity enhancement of nurse educators and nurse preceptors who facilitate nursing students acquiring competency for PPM in LMICs.
Keywords: Pain management education, Children, Scoping review, Low- and middle- income countries
Blended teaching and learning methods in nursing and midwifery education: A scoping review of the literature
Authors: Ndayisenga J.P. , Babenko-Mould Y. , Kasine Y. , Nkurunziza A. , Mukamana D. , Murekezi J. , Tengera O. , Muhayimana A. 
Published: April 2021

Background: Blended learning (BL) is defined as the combination of both traditional face-to-face learning and synchronous or asynchronous e-learning approaches. The aim of this scoping review was to explore the literature to obtain a broad understanding of the use of BLin nursing and midwifery education in general, in Sub-Saharan Africa (SSA), and in particular Rwanda.Methods: The literature published between 2010 and 2019 were reviewed from six electronic databases using keywords including blended learning, nursing education, midwifery education, higher education, SSA, and Rwanda. Arksey and O'Malley's framework was used in this review.Results: The initial search identified 1,283 records. Eleven articles were selected for this review after the application of predetermined inclusion criteria. Almost all reviewed articles indicated that the integration of BLmethods improved the quality of nursing and midwifery education in general, and in SSAcountries including Rwanda.Conclusions: Initial research in this area highlights that moving from traditional classroom-delivered programs to the BLapproach is feasible and can promote the quality of nursing and midwifery standards of education. This scoping review highlights a paucity of research on BL in nursing and midwifery education, particularly in SSAcountries.
Keywords: Blended learning, nursing and midwifery education, SSA, Rwanda
Knowledge, attitudes, and practices towards hepatitis B virus prevention among nursing students at a selected campus in Rwanda
Authors: Umuhoza A. , Nkurunziza A. , Mukashema J. , Mukarugenga M.C. , Ndayisenga J.P. , Rugema J. 
Published: April 2021

Introduction: Hepatitis B virus continues to be among the significant global challenges, and its prevention is doubtable among nursing students due to the lack of knowledge or exposure to risky behaviors in their clinical practices. This study was conducted to assess nursing students at a selected campus in Rwanda about their knowledge, attitudes, and practices towards hepatitis B prevention.Methods: A cross-sectional study design was used to conduct this study. Non-probability sampling, including convenience and snowball techniques, was used to determine the representation at all levels at a selected Campus from May to July 2018. Statistical Package for the Social Sciences (SPSS) version 26 was used for data entry. Descriptive and inferential statistics using Binary logistic regression were used to analyze the data. Institutional Review Board (IRB) of the University of Rwanda approved the study, andparticipants' rights were protected.Results: Among 171 study participants, only 140 returned the completed questionnaires, which translates to a response rate of 82.4%. Among the students who participated in this study, most were males, 75 (53.5%). The respondents' mean age was 25 years old, and the maximum age was 43. Most of the participants were from level 1 52(37.1%). The findings revealed that nursing students have adequateknowledge and practices towards HBV prevention at 65% and 71%, respectively. However, their attitudes regarding HBVprevention were negative because 96% scored at most four questions right.Conclusion: Knowledge and practices regarding HBV prevention among nursing students were quite adequate. However, a significant proportion of nursing students do not have good attitudes. These findings highlight the need to increase knowledge about HBV among nursing students in clinical orientation meetings before starting their clinical placements and introducing infection prevention and control training when they are already in clinical settings.
Keywords: Hepatitis B virus, knowledge, attitudes, practices, nursing students, Rwanda
The hazardous terrain of Diabetes mellitus in Nigeria: The time for action is now
Authors: Adeleye J.O. 
Published: April 2021

Diabetes mellitus is a chronic metabolic disease characterized by persistent hyperglycemia resulting from absolute or relative deficiencies in insulin secretion and/or action. Diabetes and its complications cause substantial morbidity, disability and premature mortality. There has been a progressive increase in the prevalence of diabetes mellitus in Nigeria and the burden is expected to increase even further. In view of the increasing burden of diabetes in Nigeria, there is an urgent need to develop and implement an effective and sustainable policy for its prevention and management in the country. If diabetes is not given the attention it deserves now, it could impose an even greater toll on health and socio-economic development in Nigeria and overwhelm an already resource constrained health care system. The time for action is now. Suggested approaches to address the burden of diabetes in Nigeriaare discussed in this commentary.
Key words: Diabetes, Burden, Nigeria, Action