bluuebunny/crossref_metadata_2025_split huggingface dataset:
5G Millimeter-Wave Beamforming System using Substrate Integrated Waveguide
Authors: Md Jizat Noorlindawaty , Yusoff Zubaida , A/L Nallasamy Arevinthran , Yamada Yoshihide 
Published: December 2021

Beamforming is a key element of 5G that uses advanced antenna technologies to focus a wireless signal to a defined direction. Butler Matrix (BM) as a beamforming network is used to control the beam direction by utilizing the amplitude and the output phase. A particular technique for designing BM is through substrate integrated waveguide (SIW), which is used to realize the bilateral edge wall vias where the waveguide mode propagates through to support the current flow and reduce the loss of surface wave. Unlike conventional BM, the proposed design requires only hybrid couplers and phase shifter without any crossover. In this BM structure, the SIW hybrid coupler is designed, with two phase shifters of -90°, and one phase shifter of -180° to control the amplitude and phase shifting. This results in an optimized transmission amplitude and output phase difference. The BM also circumvents any crossover, to provide minimal losses. The hybrid coupler exhibits Sii and Sij characteristics at 28 GHz, with values of -27.35 dB for return loss, -3.9 dB for insertion loss, -3.2 dB for coupling, and -26.54 dB for the isolation. In the BM design, high transmission efficiency is observed where the return loss is less than -10 dB, while minimal transmission amplitudes are obtained within the values of ‒6 ± 3 dB. The three-port BM is designed using SIW with minimal loss and the phase difference at each respective output port of the BM shows values of 0°, -120°, and 120°. The three consecutive beams with the gains of 11.1 dBi for port 1 excitation, 9.06 dBi for port 2 excitation and 10.4 dBi for port 3 excitation is achieved when the antenna array is fed to the BM, and each of the radiated beams has beam angles of 0, -27 and 27 degrees.
Antibacterial, antibiofilm, and cytotoxic activities and chemical compositions of Peruvian propolis in an in vitro oral biofilm
Authors: Millones Gómez Pablo Alejandro , Tay Chu Jon Lidia Yileng , Maurtua Torres Dora Jesús , Bacilio Amaranto Reyma Evelyn , Collantes Díaz Ingrit Elida , Minchón Medina Carlos Alberto , Calla Choque Jaeson Santos 
Published: December 2021

Background: Natural products with antibacterial potential have begun to be tested on biofilm models, bringing us closer to understanding the response generated by the complex microbial ecosystems of the oral cavity. The objective of this study was to evaluate the antibacterial, antibiofilm, and cytotoxic activities and chemical compositions of Peruvian propolis in an in vitro biofilm of Streptococcus gordonii and Fusobacterium nucleatum. Methods: The experimental work involved a consecutive, in vitro, longitudinal, and double-blinded study design. Propolis samples were collected from 13 different regions of the Peruvian Andes. The disk diffusion method was used for the antimicrobial susceptibility test. The cytotoxic effect of propolis on human gingival fibroblasts was determined by cell viability method using the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay, and the effect of propolis on the biofilm was evaluated by confocal microscopy and polymerase chain reaction (PCR). Results: The 0.78 mg/mL and 1.563 mg/mL concentrations of the methanolic fraction of the chloroform residue of Oxapampa propolis showed effects on biofilm thickness and the copy numbers of the srtA gene of S. gordonii and the radD gene of F. nucleatum at 48 and 120 hours, and chromatography (UV, λ 280 nm) identified rhamnocitrin, isorhamnetin, apigenin, kaempferol, diosmetin, acacetin, glycerol, and chrysoeriol. Conclusions: Of the 13 propolis evaluated, it was found that only the methanolic fraction of Oxapampa propolis showed antibacterial and antibiofilm effects without causing damage to human gingival fibroblasts. Likewise, when evaluating the chemical composition of this fraction, eight flavonoids were identified.
A computational biology approach for the identification of potential SARS-CoV-2 main protease inhibitors from natural essential oil compounds.
Authors: Hasib Rizone Al , Ali Md. Chayan , Rahman Md. Shahedur , Rahman Md. Mafizur , Ahmed Fee Faysal , Mashud Md. Abdullah Al , Islam Md. Azizul , Jamal Mohammad Abu Hena Mostofa 
Published: December 2021

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has fomented a climate of fear worldwide due to its rapidly spreading nature, and high mortality rate. The World Health Organization (WHO) declared it as a global pandemic on 11th March, 2020. Many endeavors have been made to find appropriate medications to restrain the SARS CoV-2 infection from spreading but there is no specific antiviral therapy to date. However, a computer-aided drug design approach can be an alternative to identify probable drug candidates within a short time. SARS-CoV-2 main protease is a proven drug target, and it plays a pivotal role in viral replication and transcription. Methods: In this study, we identified a total of 114 essential oil compounds as a feasible anti-SARS-CoV-2 agent from several online reservoirs. These compounds were screened by incorporating ADMET profiling, molecular docking, and 50 ns of molecular dynamics simulation to identify potential drug candidates against the SARS-CoV-2 main protease. The crystallized SARS-CoV-2 main protease structure was collected from the RCSB PDB database (PDB ID 6LU7). Results: According to the results of the ADMET study, none of the compounds have any side effects that could reduce their druglikeness or pharmacokinetic properties. Out of 114 compounds, we selected bisabololoxide B, eremanthin, and leptospermone as our top drug candidates based on their higher binding affinity scores, and strong interaction with the Cys 145-His 41 catalytic dyad. Finally, the molecular dynamics simulation was implemented to evaluate the structural stability of the ligand-receptor complex. MD simulations disclosed that all the hits showed conformational stability compared to the positive control α-ketoamide. Conclusions: Our study showed that the top three hits might work as potential anti-SARS-CoV-2 agents, which can pave the way for discovering new drugs, but for experimental validation, they will require more in vivo trials.
Modelling charge profiles of electric vehicles based on charges data
Authors: Andrenacci Natascia , Karagulian Federico , Genovese Antonino 
Published: December 2021

Background: The correct design of electric vehicle (EV) charging infrastructures is of fundamental importance to maximize the benefits for users and infrastructure managers. In addition, the analysis and management of recharges can help evaluate integration with auxiliary systems, such as renewable energy resources and storage systems. EV charging data analysis can highlight informative behaviours and patterns for charging infrastructure planning and management. Methods: We present the analysis of two datasets about the recorded energy and duration required to charge Electric Vehicles (EV) in the cities of Barcelona (Spain) and Turku (Finland). In particular, we investigated hourly, daily and seasonal patterns in charge duration and energy delivered. Simulated scenarios for the power request at charging stations (CSs) were obtained using statistical parameters of the Barcelona dataset and non-parametric distributions of the arrivals. Monte Carlo simulations were used to test different scenarios of users’ influx at the CSs, and determine the optimal size of an integrated renewable energy system (RES). Results: This study highlighted the difference between fast and slow charging users’ habits by analysing the occupancy at the charging stations. Aside from the charge duration, which was shorter for fast charges, distinct features emerged in the hourly distribution of the requests depending on whether slow or fast charges are considered. The distributions were different in the two analysed datasets. The investigation of CS power fluxes showed that results for the investment on a RES could substantially vary when considering synthetic input load profiles obtained with different approaches. The influence of incentives on the initial RES cost were investigated. Conclusions: The novelty of this work lies in testing the impact of different simulated profiles as input in the economic criterion of the net present value (NPV) for determining the size of a photovoltaic (PV) system installed at a charging infrastructure.
technical level of small-town shoemaking in Gdańsk Pomerania in the 14th century
Authors: Blusiewicz Karolina 
Published: December 2021

Based on the late medieval leather artefacts from Puck, Gniew, Lębork and Chojnice, an attempt was made to assess the level of shoemaking production at that time. Microscopic analyses of leather goods and production waste proved that in the field of tanning the activities related to the mechanical treatment of leather were carefully performed, although with insufficient professional knowledge concerning the process. The results of the identification of the animal origin of the leather confirmed the purposeful selection of raw material with different properties for individual footwear elements and the ability to properly cut it. The quality of the shoemaking products was highly rated in terms of technology and style. However, in the analysed collections a clearly perceptible difference in craftsmanship and assortment of products from Gniew and the other three towns was noticed.
Review of the genus Oncocephala Agassiz 1846 (Coleoptera: Chrysomelidae: Cassidinae: Oncocephalini) in Africa, excluding Madagascar
Authors: CALCETAS ORLANDO A. , STAINES CHARLES L. , ADORADA JESSAMYN R. , CALILUNG VENUS J. , CAOILI BARBARA L. , JAMIAS SERLIE B. 
Published: December 2021

The genus Oncocephala Agassiz, 1846 (Coleoptera: Chrysomelidae: Cassidinae: Oncocephalini) is reviewed for Africa, except Madagascar. Twenty-four species are treated. Two new synonyms were proposed, Oncocephala kolbei Gestro, 1899a is synonymized with O. promontorii Péringuey, 1898 and O. scabrosa Gestro, 1905 is synonymized with O. severinii Gestro, 1899(1901). Six new species are proposed: Oncocephala susanstainesae Calcetas, Staines & Adorada sp. nov. from Namibia, Oncocephala deleoni Calcetas, Staines and Adorada sp. nov. from the Democratic Republic of the Congo, Oncocephala camachoi Calcetas, Staines & Adorada sp. nov. from Cameroon, Oncocephala eborai Calcetas, Staines & Adorada sp. nov. from Equatorial Guinea, Oncocephala dimaculanganae Calcetas, Staines & Adorada sp. nov. from Cameroon and Oncocephala demesai Calcetas, Staines and Adorada sp. nov. from Togo. Oncocephala methneri Uhmann, 1928 and O. madoni Pic, 1941 are treated as incerte sedis. The genus Oncocephala in Africa is divided into seven species groups (Gestroi, Perrieri, Insignis, Senegalensis, Promentorii, Cuneata and Angusticollis) based on the similarity of their elytral characters. A key to the species groups and species of Oncocephala is provided.
Economic evaluation of population-based type 2 diabetes mellitus screening at different healthcare settings in Vietnam
Authors: Toi Phung Lam , Wu Olivia , Thavorncharoensap Montarat , Srinonprasert Varalak , Anothaisintawee Thunyarat , Thakkinstian Ammarin , Phuong Nguyen Khanh , Chaikledkaew Usa 
Published: December 2021

Introduction
Few economic evaluations have assessed the cost-effectiveness of screening type-2 diabetes mellitus (T2DM) in different healthcare settings. This study aims to evaluate the value for money of various T2DM screening strategies in Vietnam.

Methods
A decision analytical model was constructed to compare costs and quality-adjusted life years (QALYs) of T2DM screening in different health care settings, including (1) screening at commune health station (CHS) and (2) screening at district health center (DHC), with no screening as the current practice. We further explored the costs and QALYs of different initial screening ages and different screening intervals. Cost and utility data were obtained by primary data collection in Vietnam. Incremental cost-effectiveness ratios were calculated from societal and payer perspectives, while uncertainty analysis was performed to explore parameter uncertainties.

Results
Annual T2DM screening at either CHS or DHC was cost-effective in Vietnam, from both societal and payer perspectives. Annual screening at CHS was found as the best screening strategy in terms of value for money. From a societal perspective, annual screening at CHS from initial age of 40 years was associated with 0.40 QALYs gained while saving US$ 186.21. Meanwhile, one-off screening was not cost-effective when screening for people younger than 35 years old at both CHS and DHC.

Conclusions
T2DM screening should be included in the Vietnamese health benefits package, and annual screening at either CHS or DHC is recommended.
Staying moving, staying strong: Protocol for developing culturally appropriate information for Aboriginal people with osteoarthritis, rheumatoid arthritis, lupus and gout
Authors: O’Brien Penny , Conley Brooke , Bunzli Samantha , Bullen Jonathan , Coffin Juli , Persaud Jennifer , Gunatillake Tilini , Dowsey Michelle M. , Choong Peter F. , Lin Ivan 
Published: December 2021

IntroductionAddressing disparities in arthritis care is an important yet unmet health need for Aboriginal and Torres Strait Islander people in Australia (respectfully Aboriginal people herewith). Despite the significant prevalence and burden of arthritis within Aboriginal communities, access to care for arthritis is low. One means to reduce existing disparities in health care is to address current challenges relating to the appropriateness and acceptability of health care information resources for Aboriginal people. Health information sources can help to empower patients and their families to have greater involvement in their care and to engage in self-management of their condition. Despite an extensive range of arthritis information resources being available, currently no resources have been culturally adapted and developed in collaboration with Aboriginal consumers with arthritis. This paper outlines the processes that will be undertaken within theStaying Moving,Staying Strongproject. This project aims to develop culturally secure arthritis information for Aboriginal people with osteoarthritis, rheumatoid arthritis, lupus and gout.Methods and analysisThe overarching principle guiding this project is cultural security, referring to the incorporation of processes such that the research will not compromise the cultural rights, values and expectations of Aboriginal people. This project will prioritise partnerships, community engagement, community benefit, sustainability, transferability, and capacity building and therefore uphold the cultural rights and values of Aboriginal people. In this six-phase project we will; 1) Establish a community reference group and advisory committee; 2) Explore the health information needs and preferences of Aboriginal people with arthritis; 3) Synthesise the existing key recommendations in high quality clinical practice guidelines on arthritis care; 4) Culturally adapt key clinical recommendations; 5) Develop culturally appropriate arthritis resources and; 6) Qualitatively evaluate the developed resources.
Diagnostic and prognostic significance of premature ventricular complexes in community and hospital-based participants: A scoping review
Authors: Suba Sukardi , Fleischmann Kirsten E. , Schell-Chaple Hildy , Prasad Priya , Marcus Gregory M. , Hu Xiao , Pelter Michele M. 
Published: December 2021

Background
While there are published studies that have examined premature ventricular complexes (PVCs) among patients with and without cardiac disease, there has not been a comprehensive review of the literature examining the diagnostic and prognostic significance of PVCs. This could help guide both community and hospital-based research and clinical practice.

Methods
Scoping review frameworks by Arksey and O’Malley and the Joanna Briggs Institute (JBI) were used. A systematic search of the literature using four databases (CINAHL, Embase, PubMed, and Web of Science) was conducted. The review was prepared adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Review (PRISMA-ScR).

Results
A total of 71 relevant articles were identified, 66 (93%) were observational, and five (7%) were secondary analyses from randomized clinical trials. Three studies (4%) examined the diagnostic importance of PVC origin (left/right ventricle) and QRS morphology in the diagnosis of acute myocardial ischemia (MI). The majority of the studies examined prognostic outcomes including left ventricular dysfunction, heart failure, arrhythmias, ischemic heart diseases, and mortality by PVCs frequency, burden, and QRS morphology.

Conclusions
Very few studies have evaluated the diagnostic significance of PVCs and all are decades old. No hospital setting only studies were identified. Community-based longitudinal studies, which make up most of the literature, show that PVCs are associated with structural and coronary heart disease, lethal arrhythmias, atrial fibrillation, stroke, all-cause and cardiac mortality. However, a causal association between PVCs and these outcomes cannot be established due to the purely observational study designs employed.
Psychosocial stress and neuroendocrine biomarker concentrations among women living with or without HIV
Authors: Levy Matthew E. , Waters Ansley , Sen Sabyasachi , Castel Amanda D. , Plankey Michael , Molock Sherry , Asch Federico , Goparaju Lakshmi , Kassaye Seble 
Published: December 2021

Objective
Women living with HIV (WLWH) experience psychosocial stress related to social-structural vulnerabilities. To investigate neuroendocrine pathways linking stress and increased cardiovascular disease risk among WLWH, we evaluated associations between psychosocial stress (i.e., perceived stress, posttraumatic stress, and experiences of race- and gender-based harassment) and a composite neuroendocrine biomarker index among WLWH and women without HIV.

Methods
In 2019–2020, Women’s Interagency HIV Study participants in Washington, DC completed a questionnaire and provided blood and 12-hour overnight urine samples for testing of serum dehydroepiandrosterone sulfate (DHEA-S) and urinary free cortisol, epinephrine, and norepinephrine. Psychosocial stress was measured using the Perceived Stress Scale, PTSD Checklist-Civilian Version, and Racialized Sexual Harassment Scale. Latent profile analysis was used to classify participants into low (38%), moderate (44%), and high (18%) stress groups. Composite biomarker index scores between 0–4 were assigned based on participants’ number of neuroendocrine biomarkers in high-risk quartiles (≥75th percentile for cortisol, epinephrine, and norepinephrine and ≤25th percentile for DHEA-S). We evaluated associations between latent profile and composite biomarker index values using multivariable linear regression, adjusting for socio-demographic, behavioral, metabolic, and HIV-related factors.

Results
Among 90 women, 62% were WLWH, 53% were non-Hispanic Black, and median age was 55 years. In full multivariable models, there was no statistically significant association between psychosocial stress and composite biomarker index values among all women independent of HIV status. High (vs. low) psychosocial stress was positively associated with higher mean composite biomarker index values among all monoracial Black women (adjusted β = 1.32; 95% CI: 0.20–2.43), Black WLWH (adjusted β = 1.93; 95% CI: 0.02–3.83) and Black HIV-negative women (adjusted β = 2.54; 95% CI: 0.41–4.67).

Conclusions
Despite a null association in the overall sample, greater psychosocial stress was positively associated with higher neuroendocrine biomarker concentrations among Black women, highlighting a plausible mechanism by which psychosocial stress could contribute to cardiovascular disease risk.
Utilization of Lean & Six Sigma quality initiatives in Indian healthcare sector
Authors: Suman Gaurav , Prajapati Deo Raj 
Published: December 2021

Purpose
The purpose of this paper is to investigate the utilization of Lean & Six Sigma quality initiatives in healthcare sector in India.

Methodology
The survey questionnaires were sent to 454 hospitals through registered postal in all the states of India. The survey questionnaire was designed to assess different quality initiatives; currently implemented in Indian hospitals, factors align with organization’s objectives, reasons for not implementing Lean & Six Sigma and contribution of Lean & Six Sigma projects in healthcare improvement projects etc. A separate section in the questionnaire provides the feedback on implementation of Lean & Six Sigma in various hospitals. The relationships between Lean & Six Sigma and healthcare performance have also been established in this paper.

Findings
It is found that 15 Nos. of hospitals have implemented the Lean tools while 14 Nos. have implemented the Six Sigma tools out of 109 collected responses. This shows the utilization of Lean & Six Sigma in Indian healthcare sector. The ‘Lack of knowledge’ and ‘Availability of resources’ are the major reasons for not implementing Lean & Six Sigma. It is also observed that 22% running projects were related to Lean & Six Sigma out of various improvement projects running in various hospitals.

Originality
There is lack of evidences of similar studies that determines the utilization of Lean & Six Sigma in Indian healthcare sector at the national level. This paper will provide important breakthrough to academicians and healthcare practitioners, who are involved in Lean & Six Sigma research.

Social implications
The present study will create awareness among healthcare practitioners across India for utilization of quality tools that will provide direct benefits to the society.
Influence of Brand Awareness, Brand Association, Perceived Quality, and Brand Loyalty on Purchase Intention
Authors: Prasetia Wawan , Hidayat Anas 
Published: December 2021

This research aims to analyze the effect of brand awareness, brand association, perceived quality, and brand loyalty on purchase intention, and the approach of the theory of planned behavior. Respondents in this research were consumers and potential consumers who had purchased cement. This research used quantitative approach by distributing questionnaires to 200 respondents. Data were analyzed using the Structural Equation Method (SEM) with Partial Least Square.
The findings of this research showed that perceived quality had no impact on purchase intention, meanwhile brand awareness, brand association, and brand loyalty had positive effect on purchase intention. In addition, brand awareness, brand association, and perceived quality had positive influence on brand loyalty.