bluuebunny/crossref_metadata_2025_split huggingface dataset:
Family vitiligo impact scale: A scale to measure the quality-of-life of family members of patients with vitiligo
Authors: Agrawal S. , Satapathy S. , Gupta V. , Sreenivas V. , Khaitan B. K. , Ramam M. 
Published: July 2021

Background:
Vitiligo places a significant psycho-social burden on caregivers and family members.

Aims:
The aim of the study was to develop and preliminarily validate a scale to measure the psychosocial impact of vitiligo on adult family members.

Methods:
Themes that emerged from qualitative interviews and a focus group discussion with family members were used to generate items for a preliminary scale, followed by pre-testing and scale development. The new scale was then tested with two comparator scales and a global question.

Results:
A preliminary scale with 32 items was pilot tested on 30 participants. Following this, the scale was condensed to 16 items in 12 domains that were administered to 159 participants. Scale scores ranged from 0 to 48 with a mean of 19.75 ± 12.41. The scale had excellent internal consistency with Cronbach’s alpha coefficient of 0.92 (0.70–0.95) and also showed good test-retest reliability at two weeks (r = 0.946). The scale showed criterion, convergent and known group validity.

Limitations:
It was conducted in a large teaching hospital which may have resulted in selection of patients with persistent or progressive disease and more worried family members. Vitiligo is highly stigmatized in our country and the performance of the scale may need to be evaluated in other communities and cultures as well where stigma is less oppressive.

Conclusion:
Family Vitiligo Impact Scale appears to be an easy-to-complete, reliable and valid instrument to measure the psychosocial impact of vitiligo in family members of patients. It may be useful as an outcome measure in both clinical and research settings.
PENGARUH SALURAN DISTRIBUSI DAN PERSONAL SELLING TERHADAP VOLUME PENJUALAN PT. BORWITA CITRA PRIMA SIDOARJO
Authors: Andjarwati Tri , Nur hakim Vicky 
Published: July 2021

ABSTRACTCurrent economic activity requires a serious effort in gaining market. marketing is a very important issue that is noticed by the company in order to grow and develop. In an effort to get a market share is needed marketing strategies, so the company can achieve its goals. In achieving the goals of the company it takes effort to maximize all the opportunities that exist to be profitable for the company. The purpose of this study is to determine the distribution channel variables and personal selling simultaneously or partially significant effect on the sales volume of PT.Borwita Citra Prima Sidoarjo and to know that the distribution channel variable is the variable that has the most dominant influence on sales volume PT.Borwita Citra Prima Sidoarjo. The data analysis technique used in this research is using multiple linear regression with correlation test, determination, f test and t test with questionnaire tool and interview with sample of 60 respondents. The test result of this research is got result of doubled linear regression calculation that is Y = - 0,099 + 0,357 X1 + 0,628 X2 where both of variable have positive influence and direction with dependent variable that is sales volume PT.Borwita Citra Prima Sidoarjo. Simultaneous test results obtained Fcount of 123.753 which means Fcount 123.753> Ftable 3.16, or can be seen from the level of significance 0,000 <0,05 (Î± = 5%). While partially obtained Thitung Distribution Channel (X1) = 2.855, ThitungPersonal Seling (X2) = 4,623, thus Thitung> Ttabel (2,00247). So the hypothesis that the variables Channel Distribution And Personal Selling simultaneously or partially significant effect on sales volume PT.Borwita Citra Prima Sidoarjo proved true. Variable Personal Selling (X2) has the most dominant influence on sales volume because it has the largest regression coefficient is 0.628 than other variables.Â Keywords: Distribution Channels, Personal Selling, Sales Volume
ANALISIS PORTOFOLIO SEBAGAI DASAR PENGAMBILAN KEPUTUSAN INVESTASI SAHAM YANG TERDAFTAR PADA BURSA EFEK INDONESIA (BEI) (Studi pengunaan Model Indeks Tunggal pada saham yang terdaftar di LQ45 Periode Februari 2014 s.d Juni 2015 )
Authors: Astawinetu Erwin dyah , Fitriyah Lailatul 
Published: July 2021

ABSTRACTThis study aims to determine the optimal shares listed on the Indonesia Stock Exchange Â (IDX)Â containedÂ in Â LQ45Â using the Â methodÂ ofÂ single Â index model. Â This Â research Â is Â a Â descriptive Â study, Â the Â method Â usedÂ is Â quantitative method.Â Samples were Â taken at thirty-sixÂ shares of the company from Â LQ45 period February 2014 to June 2015. The samples were taken using purposive sampling technique. Results from this research that showed that out of thirty-six stock companies only two shares optimal namely PT. Gudang Garam Tbk. (GGRM) and PT. AKR Corporindo Tbk. (AKRA). With the proportion of funds PT. Gudang Garam Tbk. (GGRM) of 0.6624, while PT PT. AKR Corporindo Tbk. (AKRA)Â ofÂ 0.3376. Â InÂ addition Â the Â rate Â ofÂ return Â from Â the Â formationÂ of Â the portfolio is equal to 0.0084 at the risk of the portfolio amounted to 0.000017 smallerÂ Â thanÂ Â marketÂ Â riskÂ Â amountedÂ Â toÂ Â 0.001404.Â Â ThisÂ Â provesÂ Â thatÂ Â the establishment of a portfolio would gain optimal benefit with certain risk.Â Keywords: Optimal Portfolio, Single Index Model, risk, rate of return. Â
MENENTUKAN FUNGSI FAKTOR RASIO TERHADAP KINERJA PERUSAHAAN MANUFAKTUR DENGAN MENGGUNAKAN FUZZY PADA PERUSAHAAN PUBLIK YANG TERDAFTAR DI BURSA EFEK INDONESIA (BEI)
Authors: Ikhsan Teguh Pribadi , Junaedi Hartarto , Purwanto Devi Dwi 
Published: July 2021

Pemilihan Investasi di Bursa Saham menjadi salah satu opsi yang cukup bagus untuk memperoleh keuntungan. Dengan menghitung Pertumbuhan keuntungan dari Rasio Kinerja Perusahaan terdiri dari beberapa 6 Faktor antara lain Debt to Equity Ratio (DER), Return on Asset (ROA), Current Ratio (CR), Return on Equity (ROE), Gross Profit Margin (GPM) dan Total Asset Turnover (TAT). di perusahaan manufaktur. Berdasarkan rasio yang diperoleh dapat digunakan untuk pertimbangan Investasi. Metode Fuzzy yang digunakan untuk melakukan perhitungan adalah Mamdani dengan masing-masing 3 variabel linguistik disetiap Input dan Output. Dalam perhitungan ini sangat membantu kepada calon investor sebagai pertimbangan jika ingin melakukan Investasi. Dengan hasil perhitungan evaluasi dengan menggunakan Mean Absolute Percentage Error (MAPE) sebesar 0,2455.
PENCIPTAAN NARASI PRODUK BUDAYA MASYARAKAT DESA PLUNTURAN KECAMATAN PULUNG KABUPATEN PONOROGO
Authors: Prasaja Y.B. Agung , Wahyudi Edy 
Published: July 2021

ABSTRACT
Narrative can grow and develop regardless of geographical background. Of the various definitions of narrative, most of them relate the two main characteristics of it, namely: 1) events, governed by temporality-chronology of events and their presentation in the text; 2) telling or making a story, as a verbal act of mediation. Narrative is used to accommodate the interests of society such as ideology, nationalism, social relations, cultural order. These aspects include natural aspects, geographical aspects, social aspects, cultural aspects, political aspects, historical aspects, philosophical aspects, anthropological aspects, economic aspects, language aspects, artistic aspects, mythological aspects, technological aspects. Research on the ethnographic aspects of the people of plunturan village seeks to reveal the problems formulated as follows; 1. How is the construction of cultural products built by the villagers of plunturan, pulung district, kab. Ponorogo. 2. How the narrative was created by the villagers of Plunturan Pulung, Ponorogo? The phenomenon of narrative, literary works, art works, and cultural products are entities that are interrelated with one another, this also occurs in the community of plunturan village. Ethnography is defined as a form of investigation that relies heavily on participant observation, at least researchers are in a marginal position, trying to document in detail, patterns of interaction, people's perspectives, and patterns of their daily understanding and manifest the imagination of the people of plunturan kec. Pulung kab ponorogo in narrative form.

Keywords: ethnography, narrative, culture, local, interdisciplinary
EFEKTIFITAS PENGGUNAAN PENDEKATAN PENDIDIKAN MATEMATIKA REALISTIK (PMR) UNTUK MENINGKATKAN KEMAMPUAN BERPIKIR KRITIS SISWA SEKOLAH DASAR
Authors: Nurmalita Rahmaudina Andin , Hardjono Nyoto 
Published: July 2021

Penelitian ini bertujuan untuk menganalisis kembali efektifitas penggunaan pendekatan pendidikan matematika realistik (PMR) untuk meningkatkan kemampuan berpikir kritis siswa SD.
Metode penelitian adalah meta-analisis. Langkah pertama, peneliti merumuskan masalah terlebih dahulu, kemudian mengumpulkan data penelitian yang sudah ada melalui penelusuran jurnal online, repository, dan google scholar atau google cendekia. Data penelitian yang didapatkan berupa 6 artikel dan 1 hasil skripsi yang paling relevan. Peneliti menganalisis hasil penelitian dengan menggunakan metode pembanding kuantitatif. Berdasarkan hasil analisis, penggunaan
pendekatan pendidikan matematika realistic (PMR) efektif digunakan dalam meningkatkan kemampuan berpikir kritis siswa SD. Peningkatan kemampuan berpikir kritis siswa SD mulai dari
yang terendah yang terendah 6,98 % sampai yang tertinggi 46,97 % dengan rata-rata peningkatan sebesar 28,19 %.
Perancangan Sistem Informasi Sumber Daya Manusia Unit Kesehatan Berbasis Dekstop Pada Klinik Pratama Pusdikkes Kramat Jati Jakarta
Authors: Rizal Khairul , Fibriany Firstianty Wahyuhening , Mustajib Ahmad 
Published: July 2021

Kemajuan teknologi disertai tingginya mobilitas kerja memberikan persaingan ketat di jaman modern saat ini, Pendataan pegawai mulai dari absensi pegawai, penilaian kinerja pegawai dan pendataan cuti atau ijin pegawai, secara tidak langsung membutuhan sistem yang sudah terkomputerasi. Sistem yang terkomputerisasi lebih baik dari sistem yang manual agar berjalan lebih efektif dan efisien serta sistem pendataan yang sekarang lebih kondusif dibandingkan dengan sistem manual. Klinik Pratama Pusdikkes salah satu klinik kesehatan yang berada di kramat Jati Jakarta yang sampai saat ini belum terkomputerisasi terutama Dalam mengelola data dokumen sumber daya manusia unit kesehatan sehingga memungkinkan pada saat proses berlangsung terjadi kesalahan dalam pendataan, kurang akuratnya laporan yang dibuat dan keterlambatan dalam pencarian data-data yang diperlukan. Media yang digunakan berupa kertas sehingga mengakibatkan data mudah hilang, rusak dan kotor, sehingga membutuhkan waktu yang cukup lama untuk membuat dan mengolah kembali data-data tersebut.
Місія університету в суспільстві: формування університетської традиції та сучасні виклики
Authors: Zayachuk Yuliya , Kovalska Olena 
Published: July 2021

Досліджено ключові аспекти формування місії університету як наукової, педагогічної та соціальної інституції в різні історичні епохи, у період сучасності та в перспективі. Показано, що опорними її складовими були і залишаються наукове дослідження, навчання та служіння суспільству, до яких у різний час додавалися інші концепти відповідно до суспільних запитів. Акцентовано, що важливою віхою в історії університету як інституції стала реформа німецького культурного діяча та мислителя В. фон Гумбольдта, базована на інтеграції дослідження і викладання, принципах свободи викладання і навчання, яка серйозно вплинула на розвиток вищої освіти в усьому світі та стала передумовою сучасної реформи вищої освіти. Висвітлено авторські концепції місії університету впливових дослідників Дж. Ньюмена, А. Флекснера, К. Ясперса, Т. Веблена, К. Керра, Х. Ортеги-і-Гассета. Проаналізовано новітні концепції університету – дослідного університету світового класу XXI ст. проф. Ф. Альтбаха та підприємницького університету проф. Б. Кларка. Досліджено питання сучасного переосмислення місії університету.
Безперервна освіта як домінанта сучасної освітньої парадигми
Authors: Volkovetska Romana , Mudrokha Valentyna , Demchuk Nataliia 
Published: July 2021

Робота присвячена питанням розвитку системи безперервної освіти як домінанти сучасної освітньої доктрини. Обґрунтовано потребу якнаймасштабніших досліджень явища й становлення окремої спеціальної парадигми і на теоретичному, і на практичному рівнях, зважаючи на поліпрофесіоналізм як характерну ознаку ринку праці, процеси професійної глобалізації, пріоритет інформаційних технологій, запровадження як пріоритетного компетентнісного підходу, критично малий період напіврозпаду сучасних компетентностей. На основі аналізу розрізнених елементів із досвіду становлення й запровадження безперервної освіти синтезовано основні проблемні питання, вирішення яких забезпечить формування цілісної парадигми системи безперервної освіти, а саме: 1) нормування терміносистеми безперервної освіти; 2) формування загально-державної освітньої стратегії на рівні принципів, завдань, структури, форм і методів тощо; 3) забезпечення належного нормативно-правового забезпечення функціонування безперервної освіти як цілісної системи на рівні законів і підзаконних актів; 4) формування на базі інфраструктури із профільних інституцій та організацій оптимальної ієрархії закладів освіти, які створюватимуть і надаватимуть освітні продукти й освітні послуги у рамках безперервної освіти; 5) використання сучасних інформаційних технологій електронного навчання.
MENINGKATKAN PERKEMBANGAN BAHASA ANAK DENGAN PERMAINAN MENYAMBUNG CERITA DI KELOMPOK B TK NEGERI 01 PAKAN RABAA KECAMATAN KOTO PARIK GADANG DIATEH KABUPATEN SOLOK SELATAN
Authors: Firdawati Yeni 
Published: July 2021

Permasalahan yang ditemukan dalam penelitian ini adalah kemampuan perkembangan bahasa anak masih rendah. Hal ini terjadi karena permainan menyambung cerita yang digunakan guru kurang menarik dalam pembelajaran, bahkan anak bingung untuk mengunakannya. Pemilihan perkembangan bahasa dengan permainan menyambung cerita yang tidak tepat oleh guru menjadi penyebab terjadinya kondisi ini dan anak juga kurang memuaskan dalam perkembangan bahasa anak dengan permainan menyambung cerita.
Tujuan penelitian ini untuk meningkatkan perkembangan bahasa anak di kelompok B TK 01 Pakan Rabaa Kecamatan Koto Parik Gadang Diateh Kabupaten Solok Selatan. Subjek penelitian ini anak kelompok B dengan jumlah anak 20 orang terdiri dari 10 perempuan dan 10 laki- laki. Jenis penelitian ini adalah Penelitian Tindakan Kelas (PTK) dilakukan dalam dua siklus dengan tahapan masing – masing siklus sebagai berikut: perencanaan, pelaksanaan, pengamatan, refleksi, dan dokumentasi, kemudian diolah dan di analisis dengan rumus persentase.
Manfaat Penelitian Tindakan Kelas (PTK) ini adalah agar kemampuan perkembangan bahasa anak dengan permainan menyambung cerita meningkat. Hasil penelitian rata- rata persentase kemampuan perkembangan bahasa anak dapat dilihat dari sebelum tindakan, sampai siklus II. Sebelum tindakan kemampuan bahasa anak masih rendah, pada siklus I mulai meningkat namun belum mencapai KKM. Pada siklus II meningkat lagi sehingga sudah melebihi Kriteria Ketuntasan Minimal ( KKM) yang ditetapkan.
Berdasarkan hasil Penelitian Tindakan Kelasa (PTK) dilakukan dapat disimpulkan bahwa permainan menyambung cerita di kelompok B terjadi peningkatan, yaitu persentase perkembangan bahasa anak pada indikator 1, siklus I 40% pada siklus II meningkat menjadi 75%, perkembangan bahasa anak pada indikator 2, siklus I 55% pada siklus II meningkat menjadi 70%, perkembangan bahasa anak pada indikator 3, siklus I 30%, pada siklus II meningkat menjadi 65%, dan perkembangan bahasa anak pada indikator 4, siklus I 30 %, pada siklus II meningkat menjadi 80%. Pada siklus II perkembangan bahasa anak sudah meningkat, ini dapat dilihat dari hasil nilai yang sudah banyak mendapatkan kategori BSH dan BSB. Sehingga dapat disimpulkan bahwa PTK ini berhasil meningkatkan perkembangan bahasa anak dengan permainan menyambung.
KAJIAN STRUKTUR SOSIAL MASYARAKAT NELAYAN DI EKOSISTEM PESISIR (Study of Social Structure of the Fisherman Community in Coastal Ecosystem)
Authors: Handrina Emi 
Published: July 2021

Research aim is to analyse any social changes and dynamic of space capacity and critical point of social structure in coastal ecosystem. The main factor of structural change is external factor of structural formation (individu , system), or increase of community access to the change of local social environment, and external social environment.
Dynamics of space capacity of social structure in coastal ecosystem of Bungus Teluk Kabung Padang during periode of research can be explained through the two indicators, objective and subjective. There are a general critical point and a special critical point.
This results explain that a evolution theory suggest a high possibility to be synthesized with any other theories, e.g. a conflict theory, an equilibrium theory, and a “timbul-tenggelam” theory. The synthesis process is an operational stage in a schematic mapping of theories by Appelbaum. Dynamics of social structure must be known bt any goverment and NGO, which have any development plans in the fisherman community.
Epidemiology of Myopia in Children of the Russian Federation and Analysis of Its Control Methods
Authors: Myagkov A. V. , Poskrebysheva Zh. N. , Zhabina O. A. , Myagkov D. A. 
Published: July 2021

The increasing prevalence of myopia is observed all over the world, and Russia is no exception. In this regard, obtaining new data on its epidemiology among children and assessing methods of its control in real clinical practice are highly topical matters.Purpose. The purpose of this work was to assess the current issues of the epidemiology and treatment of progressive myopia in children in various regions of the Russian Federation.Materials and methods. We conducted a prospective multicenter epidemiological observational questionnaire study. This study involved 106 doctors from 53 regions of Russia and 2931 parents of myopic children.Results. 50% of the surveyed doctors noted that the manifestation of myopia is diagnosed in children aged 10–12 years, while 43% noted the same in children aged 7–9 years. According to 74.5% of doctors, the degree of the newly diagnosed myopia ranges from –1.25 to –3.00 diopters, 25.5% of doctors reported that it is below –1.0 diopters. The majority of doctors (73.6%) assess accommodation in myopic children, considering it one of the progression factors. 52.9% of ophthalmologists prescribe optical correction in cases when monocular distance visual acuity amounts to 0.6 (decimal scale) or lower values, while 29.2%, 16% and 1.9% of the surveyed ophthalmologists prescribe optical correction in cases when monocular distance visual acuity amounts to 0.7, 0.8 and 0.9 respectively.The following optical methods for juvenile myopia control are recommended by the doctors: orthokeratology contact lenses (53.8%), spectacles for full correction (51.9%), peripheral defocus-inducing (bifocal) soft contact lenses (18.9%), while 4.7% of the surveyed doctors utilized other methods of myopia control, which were not indicated in the questionnaire.Conclusion. In most cases, manifestation of myopia is diagnosed in children aged 7–12 years. Its degree ranges from –1.25 to –3.0 diopters, which indicates its late diagnosis; optical correction is prescribed mainly in cases when monocular distance visual acuity is 0.6 or lower; most ophthalmologists assess accommodation in myopic children, considering it a progression factor. As methods of myopia control, doctors utilize optical correction, device-assisted therapy and pharmacological treatment of accommodative disorders, while parents prefer methods that require minimum time expenditures.
Exosomes Derived From Adipose-Derived Mesenchymal Stem Cells Ameliorate Radiation-Induced Brain Injury by Activating the SIRT1 Pathway
Authors: Liu Mengdong , Yang Yunshu , Zhao Bin , Yang Yuefan , Wang Jing , Shen Kuo , Yang Xuekang , Hu Dahai , Zheng Guoxu , Han Juntao 
Published: July 2021

ObjectiveStudies have shown that the therapeutic effects of mesenchymal stem cells (MSCs) are mediated in a paracrine manner, mainly through extracellular vesicles such as exosomes. Here, we designed a study to investigate whether exosomes derived from adipose-derived mesenchymal stem cells (ADMSC-Exos) had protective effects in a rat model of radiation-induced brain injury and in microglia.MethodsMale adult Sprague-Dawley (SD) rats were randomly divided into three groups: the control group, the radiation group (30 Gy), and the radiation + exosomes group (30 Gy + 100 ug exosomes). Meanwhile, microglia were divided into four groups: the control group, the radiation group (10 Gy), the radiation + exosomes group (10 Gy + 4 ug exosomes), and radiation + exosomes + EX527 group (10 Gy + 4 ug exosomes + 100 nM EX527). Tissue samples and the levels of oxidative stress and inflammatory factors in each group were compared.ResultsStatistical analysis showed that after irradiation, ADMSC-Exos intervention in vivo significantly reduced the levels of caspase-3, malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4), and promoted the recovery of superoxide dismutase (SOD), catalase (CAT), IL-4, and IL-10. Moreover, ADMSC-Exos intervention inhibited microglial infiltration and promoted the expression of SIRT1. Furthermore, the results in vitro showed that the above effects of ADMSC-Exos could be reversed by SIRT-1 inhibitor EX527.ConclusionThis study demonstrated that ADMSC-Exos exerted protective effects against radiation-induced brain injury by reducing oxidative stress, inflammation and microglial infiltration via activating the SIRT1 pathway. ADMSC-Exos may serve as a promising therapeutic tool for radiation-induced brain injury.
Sex Differences in Biopsy-Confirmed Diabetic Kidney Disease
Authors: Wang Yiting , Zhang Jue , Zhang Junlin , Wu Yucheng , Zhang Rui , Ren Honghong , Cooper Mark E. , Liu Fang 
Published: July 2021

BackgroundTo investigate the association between sex differences and end-stage kidney disease (ESKD) in patients with biopsy-confirmed diabetic kidney disease (DKD).MethodWe performed a retrospective cohort study. A total of 336 patients with biopsy-confirmed DKD who were followed up for at least 12 months were enrolled. Baseline clinical and pathological data at the time of biopsy were collected. ESKD was defined by an estimated glomerular filtration rate of &lt;15 ml/min/1.73 m2or initiation of renal replacement therapy. The association between sex differences and ESKD was assessed using the log-rank test and Cox regression.ResultThere were 239 (71%) male and 97 (29%) female patients in our cohort. Female patients had higher systolic blood pressure, total cholesterol and low-density lipoprotein cholesterol levels compared with male. There were a lower proportion of female patients in the very high risk grade according to the chronic kidney disease categories (37% of female vs. 44% of male). During a median follow-up time of 20 months, 101 (57.7%) male and 43 (44.3%) female entered into ESKD, with no significant difference by the log-rank test (P &gt;0.05). Univariate [male: hazard ratio (HR) [95% confidence interval (CI)], 1.005, (0.702–1.439)] and multivariable ([male: HR (95%CI), 1.164, (0.675–2.007)]. Cox regression further showed that sex difference was not significantly associated with ESKD.ConclusionFemale patients had the higher systolic blood pressure, total cholesterol, LDL-C, compared with male patients. However, there was no significant association observed between sex difference and ESKD in our study.