bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is tele‐rehabilitation superior to home exercise program in COVID‐19 survivors following discharge from intensive care unit? ‐ A study protocol of a randomized controlled trial
Authors: Turan Zeynep , Topaloglu Mahir , Ozyemisci Taskiran Ozden 
Published: July 2021

AbstractBackground and PurposeEvaluating the patients with COVID‐19 following discharge from intensive care unit for pulmonary rehabilitation is crucial. It could be difficult to participate rehabilitation program due to transportation problems and cautions for contagiousness. Tele‐rehabilitation could serve as a favorable alternative. The primary aim of this study is to investigate whether supervised telerehabilitation is superior to home exercise program regarding walking distance and secondarily muscle strength, muscle endurance, quality of life, physical activity level and perceived respiratory disability.MethodsThis is a randomized assessor blinded control trial with two groups; tele‐rehabilitation and home exercise. One hundred twenty‐two COVID‐19 survivors following discharge from intensive care unit will be allocated into two groups. The tele‐rehabilitation group will receive breathing, aerobic, posture, stretching, strengthening exercises at their home under remote supervision via Internet for 3 days/week for 10 weeks. Home exercise group will receive the same program at their home on their own and they will be called weekly. The patients will be evaluated at the beginning, at the end of the program, 6th and 12th months following the rehabilitation. The primary outcome is the change in 6‐minute walking distance; the secondary outcomes are changes in quality of life, physical function, health status, dyspnea and muscle strength.Impact StatementThis detailed description of the rehabilitation protocol will guide to plan the rehabilitation program and help how to design an efficacy study comparing different models of rehabilitation in COVID‐19 survivors following discharge from intensive care unit with evidence‐based contribution to the literature.
Synergistic effect of natural clinoptilolite with non‐lethal repellents in anti‐rodent dry food packaging
Authors: Yücetürk Mert , Kuru Buket , Seydibeyoğlu Mehmet Özgür 
Published: July 2021

AbstractRodents cause enormous damage to stored foods. Anticoagulant rodenticides used to eliminate rodents cannot be used in food packaging because they are toxic to humans. In this study, the use of various non‐lethal repellents and natural clinoptilolite in food packaging has been investigated. For this, capsicum oleoresin was used because of the burning sensation created by the mammals' mouths. Denatonium benzoate and denatonium saccharide were used because of their extremely bitter taste. Finally, natural clinoptilolite was used to absorb the smell of foods, and its synergistic effect was observed with repellents. The additives were mixed with polypropylene carrier and converted into anti‐rodent masterbatches in a laboratory‐type extruder. Then, packaging films were prepared by a cast film extruder. These films were used for the packaging of mouse foods in pellet form with the aid of a heat‐seal tester. In experiments on house mice (Mus musculus), a mixture of repellent additives capsicum oleoresin, denatonium benzoate, denatonium saccharide and odour‐absorbing natural clinoptilolite showed 100% repellency synergistically.
Interfacial Control of NiCoP@NiCoP Core–Shell Nanoflake Arrays as Advanced Cathodes for Ultrahigh‐Energy‐Density Fiber‐Shaped Asymmetric Supercapacitors
Authors: Li Qiulong 
Published: July 2021

AbstractEfficient improvement of the energy density and overall electrochemical performance of fiber‐shaped asymmetric supercapacitors (FASCs) for practical applications in portable and wearable electronics requires highly electrochemically active materials and a rational design. Herein, two‐step phosphorization (TSP) processes are performed to directly grow 3D well‐aligned NiCoP@NiCoP (NCP@NCP TSP) nanoflake arrays (NFAs) on carbon nanotube fibers (CNTFs). Profiting from the metallic characteristics and excellent electrochemical performance of NiCoP and the hierarchical design of the core–shell heterostructure, the NCP@NCP TSP NFAs/CNTF hybrid electrode exhibits significantly improved electrochemical performance. The as‐fabricated NCP@NCP TSP NFAs/CNTF electrode possesses an ultrahigh areal capacitance of 10 035 mF cm−2 at a current density of 1 mA cm−2, with excellent rate capability and cycling stability. Furthermore, an FASC device with a maximum operating voltage of 1.6 V is assembled by adopting NCP@NCP TSP NFAs/CNTF as a positive electrode, hierarchical TiN@VN core–shell heterostructure nanowire arrays (NWAs)/CNTF as negative electrode, and KOH‐PVA as a gel electrolyte. The FASC device exhibits a high areal capacitance of 430.4 mF cm−2 and an ultrahigh energy density of 51.02 mWh cm−3. Thus, the rationally designed NiCoP@NiCoP electrode is a promising candidate for incorporation into next‐generation wearable and portable energy‐storage devices.
Simple and rapid analysis of Linagliptin in dried blood spot using an ionic liquid based vortex‐assisted dispersive liquid–liquid microextraction coupled with liquid chromatography–electrospray ionization–tandem mass spectrometry: Application to pharmacokinetic studies
Authors: Arnipalli Manikanta Swamy , Nimmu Narendra Varma , Bondigalla Ramachandra , Challa Gangu Naidu 
Published: July 2021

AbstractA simple, rapid, and convenient ionic liquid based vortex‐assisted dispersive liquid–liquid micro extraction method for the determination of Linagliptin was developed. The main novelty of the present work deals with the analysis of Linagliptin in dried blood spot with significant advantages with regard to invasive sampling, volume of blood used (< 20 μL), storage and transport of biological materials and requirements for special biohazard arrangements. The extraction sample was assayed using liquid chromatography–tandem mass spectrometry using electropray ionization techniques. The effects of significant factors in extracting and disperser solvent, and salt contents were investigated. An efficient quantification method was developed for bioassay of Linagliptin using Sitagliptin as internal standard through Inertsil ODS‐3V (250 mm × 4.6 mm, 5 μm) column using 10 mM ammonium acetate buffer (pH adjusted to 4.6 with 0.1% Trifluoroacetic acid): Acetonitrile [10:90 (v/v)] as mobile phase. Tandem mass spectrometry detection was performed to monitor precursor → product ion transitions m/z 473.3 → 364.2 for Linagliptin, m/z 408.2 → 235.1 for internal standard. The assay was linear from 6 to 1500 ng/mL and the mean recoveries are more than 90%. The peak dried blood spot concentration (Cmax) after 1.5 h was determined to be 1391.2 ng/ml for Linagliptin.
A unified quartet DNA gel electrophoresis instrument with integrated agarose gel casting, electrophoresis, staining, and imaging facilities
Authors: Maurye Praveen , Basu Arpita , Kumari Kavita , Dey Priyanka , Sen Sohini , Devi Manoharmayum Shaya 
Published: July 2021

AbstractAgarose gel electrophoresis is the most useful and revolutionary process for separating, analyzing, identifying, and purifying different DNA fragments (in shape or size) from any cell or organism. This process is an amalgamation of four associated techniques viz. gel casting, electrophoresis, staining, and imaging, which are consecutively accomplished to get desired results. Various types of commercialized/non‐commercialized device and reagent kits are available with manufacturers to perform the associated techniques with simplicity. All these devices need secure space, separate operating procedures, and timely maintenance for the long run. In the absence of a low‐cost integrated electrophoresis device that can be utilized for the complete gel electrophoresis process, untimely operational failure of any individual equipment affects the experiment. In this paper, we describe an integrated gel electrophoresis instrument, which provides all facilities for agarose gel casting, electrophoresis, staining, and imaging techniques without any exposure to harmful chemicals. Construction of this four‐in‐one instrument in the laboratory requires off‐the‐shelf and pre‐existing components. Overall estimated cost is nearly US$ ∼222.00; and it can be assembled within 1 h, which makes it an inexpensive, user‐friendly, and effortless system. It has proved to be advantageous for researchers working in wide varieties of laboratories on the evaluation of nucleic acids.
Laparoscopic‐assisted cutaneous ureterostomy in a canine patient with prostatic carcinoma
Authors: Allevi Giovanni , Spediacci Carlotta , Marchesi Elena , Trovatelli Marco 
Published: July 2021

AbstractA 9‐year‐old neutered male Dachshund dog was assessed for stranguria. An enlarged prostate was identified on physical examination, and a diagnosis of prostatic carcinoma confirmed by cytology. Due to a neoplastic lower urinary tract obstruction, palliative surgical urinary diversion treatment was performed with laparoscopic assisted cutaneous ureterostomy (LACU). The dog recovered well without any major complications. Adjuvant chemotherapy was maintained and continued for post‐surgical medical therapy. This report describes a novel minimally invasive assisted technique in canine patients for palliative treatment of prostatic neoplasia.
Three-parameter deformation of ℝ × S3 in the Landau-Lifshitz limit
Authors: Nieto García Juan Miguel , Wyss Leander 
Published: July 2021

Abstract
In this article we construct the effective field theory associated to the ℝ × S3 sector of the three-parameter deformation of AdS3 × S3 × T4 in the Landau-Lifshitz approximation. We use this action to compute the dispersion relation of excitations around the BMN vacuum and the perturbative S-matrix associated to them. We are able to compute and sum all the different loop contributions to the S-matrix in this limit.
Anomalous dimensions of monopole operators in scalar QED3 with Chern-Simons term
Authors: Chester Shai M. 
Published: July 2021

Abstract
We study monopole operators with the lowest possible topological charge q = 1/2 at the infrared fixed point of scalar electrodynamics in 2 + 1 dimension (scalar QED3) with N complex scalars and Chern-Simons coupling |k| = N. In the large N expansion, monopole operators in this theory with spins $$ \mathrm{\ell}<O\left(\sqrt{N}\right) $$
ℓ
<
O

N

and associated flavor representations are expected to have the same scaling dimension to sub-leading order in 1/N. We use the state-operator correspondence to calculate the scaling dimension to sub-leading order with the result N − 0.2743 + O(1/N), which improves on existing leading order results. We also compute the ℓ2/N term that breaks the degeneracy to sub-leading order for monopoles with spins $$ \mathrm{\ell}=O\left(\sqrt{N}\right) $$
ℓ
=
O

N

.
The $$ \overline{B} $$ → π form factors from QCD and their impact on |Vub|
Authors: Leljak Domagoj , Melić Blaženka , van Dyk Danny 
Published: July 2021

Abstract
We revisit light-cone sum rules with pion distribution amplitudes to determine the full set of local $$ \overline{B} $$

B
¯

→ π form factors. To this end, we determine all duality threshold parameters from a Bayesian fit for the first time. Our results, obtained at small momentum transfer q2, are extrapolated to large q2 where they agree with precise lattice QCD results. We find that a modification to the commonly used BCL parametrization is crucial to interpolate the scalar form factor between the two q2 regions. We provide numerical results for the form factor parameters — including their covariance — based on simultaneous fit of all three form factors to both the sum rule and lattice QCD results. Our predictions for the form factors agree well with measurements of the q2 spectrum of the semileptonic decay $$ {\overline{B}}^0\to {\pi}^{+}{\mathrm{\ell}}^{-}{\overline{\nu}}_{\mathrm{\ell}} $$

B
¯

0

→

π
+

ℓ
−

ν
¯

ℓ

. From the world average of the latter we obtain |Vub| = (3.77 ± 0.15) · 10−3, which is in agreement with the most recent inclusive determination at the 1 σ level.
Convex-Cyclic Weighted Composition Operators and Their Adjoints
Authors: Mengestie Tesfa 
Published: July 2021

AbstractWe characterize the convex-cyclic weighted composition operators $$W_{(u,\psi )}$$

W

(
u
,
ψ
)

and their adjoints on the Fock space in terms of the derivative powers of $$ \psi $$
ψ
and the location of the eigenvalues of the operators on the complex plane. Such a description is also equivalent to identifying the operators or their adjoints for which their invariant closed convex sets are all invariant subspaces. We further show that the space supports no supercyclic weighted composition operators with respect to the pointwise convergence topology and, hence, with the weak and strong topologies, and answers a question raised by T. Carrol and C. Gilmore in [5].
Contractive Iterated Function Systems Enriched with Nonexpansive Maps
Authors: Strobin Filip 
Published: July 2021

AbstractMotivated by a recent paper of Leśniak and Snigireva [Iterated function systems enriched with symmetry, preprint], we investigate the properties of the semiattractor $$A_{\mathcal {F}\cup \mathcal {G}}^*$$

A

F
∪
G

∗

of an IFS $$\mathcal {F}$$
F
enriched by some other IFS $$\mathcal {G}$$
G
. We show that in natural cases, the semiattractor $$A_{\mathcal {F}\cup \mathcal {G}}^*$$

A

F
∪
G

∗

is in fact the attractor of certain IFSs related naturally with the IFSs $$\mathcal {F}$$
F
and $$\mathcal {G}$$
G
. We also give an example when $$A_{\mathcal {F}\cup \mathcal {G}}^*$$

A

F
∪
G

∗

is not compact, yet still being the attractor of considered related IFSs. Finally, we use presented machinery to prove that the so called lower transition attractors due to Vince are semiattractors of enriched IFSs.
Parodontitis – Therapie einer Volkskrankheit
Authors: Dannewitz Bettina , Holtfreter Birte , Eickholz Peter 
Published: July 2021

ZusammenfassungParodontitis ist eine chronisch entzündliche nichtübertragbare Erkrankung, die alle Anteile des Zahnhalteapparates (Parodonts) betrifft und dort weitgehend irreversible Schäden verursacht. Schätzungen legen nahe, dass in Deutschland ca. 10 Mio. Menschen an einer schweren Parodontitis erkrankt sind. Parodontitis zeigt über viele Jahre zumeist wenige oder nur milde Symptome, die von den Patienten oft nicht wahrgenommen oder richtig eingeordnet werden. Fehlendes Bewusstsein kann dazu führen, dass zahnärztliche Behandlung erst in einem fortgeschrittenen Erkrankungsverlauf in Anspruch genommen wird, wenn umfangreiche Therapiemaßnahmen notwendig geworden sind und sich die Prognose für den Erhalt der Zähne verschlechtert hat. Der parodontale Screeningindex (PSI) ist ein einfaches und schnelles Instrument, mit dem die Notwendigkeit weiterführender diagnostischer Maßnahmen beurteilt werden kann. Der Index wird mittlerweile bei vielen Patienten durchgeführt. Trotzdem bleiben die Versorgungszahlen niedrig und hinter dem zurück, was für das Absenken der bestehenden Parodontitislast notwendig wäre. Jede Zahnarztpraxis muss in der Lage sein, Parodontitistherapie umzusetzen. Fachzahnärzte oder Spezialisten können die allgemeinzahnärztlichen Kollegen wesentlich bei der Behandlung von schweren Formen von Parodontitis unterstützen. Dazu ist eine Aufwertung des Faches in der universitären Ausbildung erforderlich, aber auch die zunehmende postgraduale Ausdifferenzierung von Spezialisten oder Fachzahnärzten für Parodontologie. Die neuen Behandlungsrichtlinien für die Parodontaltherapie (PAR-Therapie) erlauben die Versorgung der parodontal erkrankten Patienten auf Basis international anerkannter wissenschaftlicher Standards und verbessern damit die Rahmenbedingungen für die Parodontitistherapie in der zahnärztlichen Praxis.
Winkelstabile Platte zur Behandlung der Insuffizienzfrakturen des Beckens („minimally invasive posterior locked compression plate“)
Authors: Schmerwitz Imke , Jungebluth Philipp , Bartels Stephan , Hockertz Thomas 
Published: July 2021

ZusammenfassungOperationszielBelastungsstabile Versorgung des Beckenringes mit hoher Primärstabilität.IndikationInstabilität und ausbleibende Mobilisierbarkeit bei osteoporotischen Beckenbrüchen.KontraindikationenDekubitalgeschwüre, Infekte.OperationstechnikMinimal-invasive winkelstabile Versorgung durch 4,5 LCP (locked compression plate, DePuy Synthes, Zuchwil, Schweiz) von dorsal.WeiterbehandlungSofortige Mobilisation mit Vollbelastung, Röntgenverlaufskontrolle.EvidenzDie Nachuntersuchung eines Kollektivs von 34 Patienten zeigte keine Implantatlockerungen sowie eine vergleichsweise niedrige Strahlenexposition.
SAHA could inhibit TGF-β1/p38 pathway in MI-induced cardiac fibrosis through DUSP4 overexpression
Authors: Wang Kaihao , Tang Ruijie , Wang Siyuan , Wang Wenyao , Zhang Kuo , Li Jun , Li Ping , Tang Yi-Da 
Published: July 2021

AbstractGrowing evidences have revealed that a histone deacetylase inhibitor (HDACi), suberoylanilide hydroxamic acid (SAHA) has anti-fibrotic effect in different diseases. In this study, we first evaluated whether SAHA could suppress cardiac fibrosis. Mice with MI-induced cardiac fibrosis were treated with SAHA by intraperitoneal injection and their cardiac function was improved after SAHA treatment. Results of western blotting and qRT-PCR in heart tissues suggested that TGFβ1/P38 pathway was activated in MI mice, and this effect was reversed by SAHA. Cell proliferation assay suggested that SAHA could suppress TGF-β1-induced cardiac fibroblasts proliferation. Furthermore, results of western blotting and qRT-PCR in cardiac fibroblasts depicted that SAHA may exert its anti-fibrotic effect through inhibiting TGF-β1-induced P38 phosphorylation by promoting DUSP4 expression. Our findings may substantiate SAHA as a promising treatment for MI-induced cardiac fibrosis.
Cerclage fixation without K-wires is associated with fewer complications and reoperations compared with tension band wiring in stable displaced olecranon fractures in elderly patients
Authors: Wenger Daniel , Cornefjord Gustav , Rogmark Cecilia 
Published: July 2021

Abstract
Introduction
Tension band wiring of olecranon fractures has high reported rates of complications and reoperations. We aimed to compare classic tension band wiring to cerclage fixation without K-wires in the treatment of displaced olecranon fractures in elderly patients. The primary outcome was reoperation. Secondary outcomes included complications and patient reported outcomes. Outcomes following non-operative treatment were also studied.

Materials and methods
Patients aged > 69 years presenting with Mayo class 2a and 2b olecranon fractures at our institution from 2004 through 2016 (n = 239) were eligible for study. Fracture type, treatment method, complications and reoperations were assessed from radiographs and hospital files. QuickDASH surveys were collected by mail.

Results
Patients operated with tension band wire technique had more reoperations (p value 0.03): relative risk (RR) 2.2 (CI 1.08–4.3), odds ratio (OR) 2.6 (CI 1.05–6.4), and complications (p value 0.001): RR 2.5 (CI 1.51–4.1), OR 3.7 (CI 1.67–8.2), compared with those operated with cerclage technique. Non-operative treatment yielded similar complication (p value 0.2) and reoperation rates (p value 0.06) as cerclage fixation. The answer rate was insufficient to compare QuickDASH scores between treatments methods.

Conclusions
In patients 70 years and older undergoing cerclage fixation for displaced stable olecranon fractures (Mayo class 2), the reoperation and complications rates were less than half of those in patients undergoing TBW fixation. Non-operative treatment yielded similar reoperation and complication rates to cerclage fixation, in selected cases.

Level of evidence
III—retrospective comparative cohort study.
LY294002 and sorafenib as inhibitors of intracellular survival pathways in the elimination of human glioma cells by programmed cell death
Authors: A Zając , J Sumorek-Wiadro , A Maciejczyk , E Langner , I Wertel , W Rzeski , J Jakubowicz-Gil 
Published: July 2021

AbstractGliomas are aggressive brain tumors with very high resistance to chemotherapy throughout the overexpression of multiple intracellular survival pathways. Therefore, the aim of the present study was to investigate for the first time the anticancer activity of LY294002, phosphatidylinositol 3-kinase (PI3K) inhibitor and sorafenib, and rapidly accelerated fibrosarcoma kinase (Raf) inhibitor in the elimination of human glioma cells by programmed cell death. MOGGCCM (anaplastic astrocytoma, III) and T98G (glioblastoma multiforme, IV) cell lines incubated with LY294002 and/or sorafenib were used in the experiments. Simultaneous treatment with both drugs was more effective in the elimination of cancer cells on the way of apoptosis with no significant necrotic effect than single application. It was correlated with decreasing the mitochondrial membrane potential and activation of caspase 3 and 9. The expression of Raf and PI3K was also inhibited. Blocking of those kinases expression by specific siRNA revealed significant apoptosis induction, exceeding the level observed after LY294002 and sorafenib treatment in non-transfected lines but only in MOGGCCM cells. Our results indicated that combination of LY294002 and sorafenib was very efficient in apoptosis induction in glioma cells. Anaplastic astrocytoma cells turned out to be more sensitive for apoptosis induction than glioblastoma multiforme after blocking PI3K and Raf expression with siRNA.
Experimental investigation of the dynamic load sharing of planetary gearboxes
Authors: Götz J. , Siglmüller F. , Fürst M. , Otto M. , Stahl K. 
Published: July 2021

AbstractDue to their compactness and power density, planetary gearboxes are used for a wide range of high-performance applications in the automotive, aviation and marine sector. Aerospace applications in particular benefit from a full use of the load capacity potential to meet the requirements for lightweight construction and efficiency. Against this background, the load sharing between the individual planetary gears plays a decisive role. A uniform load sharing enables the design of the single tooth meshes without load increases and oversizing. However, due to manufacturing and assembly deviations, a perfect load sharing is technically not feasible. These load increases are taken into account in the standard calculation of the load capacity of planetary gearboxes by the mesh load factor Kγ. The load sharing in planetary gearboxes is influenced by a number of factors, such as the rigidity of shafts, housing and bearings, the number of planets, the quality of the gear wheels and the operating conditions. Detailed simulations or extensive experimental measurements are required to determine the exact load sharing. For new designs of planetary gearboxes, there are only simplified assumptions available, based on the number of planets and a rough estimation of the operating range. Especially additional dynamic forces, due to operation in high-speed ranges or near resonance frequencies, can lead to a considerable change of the dynamic load sharing compared to the static load sharing and cause an uncertainty in the design. Thus, in this paper the dynamic load sharing behaviour is investigated from 0 to 6800 rpm sun speed for different loads. Based on the experimental data recommendations for the design of planetary gearboxes under consideration of the operating conditions are derived.