bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combination of absolute pitch and tone language experience enhances lexical tone perception
Authors: Maggu Akshay R. , Lau Joseph C. Y. , Waye Mary M. Y. , Wong Patrick C. M. 
Published: January 2021

AbstractAbsolute pitch (AP), a unique ability to name or produce pitch without any reference, is known to be influenced by genetic and cultural factors. AP and tone language experience are both known to promote lexical tone perception. However, the effects of the combination of AP and tone language experience on lexical tone perception are currently not known. In the current study, using behavioral (Categorical Perception) and electrophysiological (Frequency Following Response) measures, we investigated the effect of the combination of AP and tone language experience on lexical tone perception. We found that the Cantonese speakers with AP outperformed the Cantonese speakers without AP on Categorical Perception and Frequency Following Responses of lexical tones, suggesting an additive effect due to the combination of AP and tone language experience. These findings suggest a role of basic sensory pre-attentive auditory processes towards pitch encoding in AP. Further, these findings imply a common mechanism underlying pitch encoding in AP and tone language perception.
Substrate and cell fusion influence on slime mold network dynamics
Authors: Patino-Ramirez Fernando , Arson Chloé , Dussutour Audrey 
Published: January 2021

AbstractThe acellular slime moldPhysarum polycephalumprovides an excellent model to study network formation, as its network is remodelled constantly in response to mass gain/loss and environmental conditions. How slime molds networks are built and fuse to allow for efficient exploration and adaptation to environmental conditions is still not fully understood. Here, we characterize the network organization of slime molds exploring homogeneous neutral, nutritive and adverse environments. We developed a fully automated image analysis method to extract the network topology and followed the slime molds before and after fusion. Our results show that: (1) slime molds build sparse networks with thin veins in a neutral environment and more compact networks with thicker veins in a nutritive or adverse environment; (2) slime molds construct long, efficient and resilient networks in neutral and adverse environments, whereas in nutritive environments, they build shorter and more centralized networks; and (3) slime molds fuse rapidly and establish multiple connections with their clone-mates in a neutral environment, whereas they display a late fusion with fewer connections in an adverse environment. Our study demonstrates that slime mold networks evolve continuously via pruning and reinforcement, adapting to different environmental conditions.
Sickness and sleep health predict frustration and affective responses to a frustrating trigger
Authors: Balter Leonie J. T. , Sundelin Tina , Axelsson John 
Published: January 2021

AbstractFluctuations in health and sleep are common, but we know surprisingly little about how these daily life stressors affect one's level of frustration and sensitivity to becoming frustrated. In this pre-registered study, 517 participants (Mage = 30.4, SD = 10.4) reported their current sickness symptoms, health status, sleepiness, and sleep duration and quality the previous night. They also rated their general frustration and mood before and after a mild frustration-eliciting task. In the task, participants were instructed to copy geometric shapes onto a piece of paper, without lifting the pen from the paper. Participants were given three minutes to copy the eight shapes, but in order to induce frustration half of them were unsolvable. The study was subsequently repeated in an independent sample (N = 113). Frustration increased in response to the task; however, those with the worst sickness symptoms or sleep health reduced or did not change their frustration levels. Instead, across both studies, frustration was already high at baseline for these individuals. These findings indicate that being sick or having poor sleep is related to high general frustration, but resilience to further frustration due to mild frustrating situations.
Composition of the white precipitate formed on the surface of damaged triacetyl cellulose-based motion picture films
Authors: Takahashi Keiko , Sasaki Maiko , Hayakawa Hiroshi , Yajima Hitoshi , Oda Yoshiki 
Published: January 2021

AbstractTo achieve a better understanding of the “vinegar syndrome” phenomenon, which has caused serious damage to triacetyl cellulose-based motion picture films, the white powder obtained from damaged film surfaces was analysed in this study. The powder was found to be soluble in acetone, diethyl ether, dimethylformamide, and chloroform, but insoluble in water. From the results of 1H, 13C and 31P nuclear magnetic resonance spectroscopy, mass spectrometry, and X-ray fluorescence measurements, it was concluded that the white precipitate had a molecular weight of 326 amu and was composed of triphenyl phosphate (C18H15O4P).
Multi-slice ptychography enables high-resolution measurements in extended chemical reactors
Authors: Kahnt Maik , Grote Lukas , Brückner Dennis , Seyrich Martin , Wittwer Felix , Koziej Dorota , Schroer Christian G. 
Published: January 2021

AbstractPtychographic X-ray microscopy is an ideal tool to observe chemical processes under in situ conditions. Chemical reactors, however, are often thicker than the depth of field, limiting the lateral spatial resolution in projection images. To overcome this limit and reach higher lateral spatial resolution, wave propagation within the sample environment has to be taken into account. Here, we demonstrate this effect recording a ptychographic projection of copper(I) oxide nanocubes grown on two sides of a polyimide foil. Reconstructing the nanocubes using the conventional ptychographic model shows the limitation in the achieved resolution due to the thickness of the foil. Whereas, utilizing a multi-slice approach unambiguously separates two sharper reconstructions of nanocubes on both sides of the foil. Moreover, we illustrate how ptychographic multi-slice reconstructions are crucial for high-quality imaging of chemical processes by ex situ studying copper(I) oxide nanocubes grown on the walls of a liquid cell.
Overexpression of β-Arrestins inhibits proliferation and motility in triple negative breast cancer cells
Authors: Bostanabad Saber Yari , Noyan Senem , Dedeoglu Bala Gur , Gurdal Hakan 
Published: January 2021

Abstractβ-Arrestins (βArrs) are intracellular signal regulating proteins. Their expression level varies in some cancers and they have a significant impact on cancer cell function. In general,the significance of βArrs in cancer research comes from studies examining GPCR signalling. Given the diversity of different GPCR signals in cancer cell regulation, contradictory results are inevitable regarding the role of βArrs. Our approach examines the direct influence of βArrs on cellular function and gene expression profiles by changing their expression levels in breast cancer cells, MDA-MB-231 and MDA-MB-468. Reducing expression of βArr1 or βArr2 tended to increase cell proliferation and invasion whereas increasing their expression levels inhibited them. The overexpression of βArrs caused cell cycle S-phase arrest and differential expression of cell cycle genes,CDC45, BUB1, CCNB1, CCNB2, CDKN2Cand reduced HER3, IGF-1R, and Snail. Regarding to the clinical relevance of our results, low expression levels of βArr1 were inversely correlated with CDC45, BUB1, CCNB1, and CCNB2 genes compared to normal tissue samples while positively correlated with poorer prognosis in breast tumours. These results indicate that βArr1 and βArr2 are significantly involved in cell cycle and anticancer signalling pathways through their influence on cell cycle genes and HER3, IGF-1R, and Snail in TNBC cells.
Urinary bisphenol A concentrations and the risk of obesity in Korean adults
Authors: Moon Shinje , Seo Moon Young , Choi Kyungho , Chang Yoon-seok , Kim Shin-Hye , Park Mi Jung 
Published: January 2021

AbstractThis study was aimed to evaluate the association between urinary bisphenol A (BPA) levels and risk of obesity in Korean adults. We analyzed data from the Korean National Environmental Health Survey (KoNEHS) Cycle 2 (2012–2014) and Cycle 3 (2015–2017). A total of 10,021 participants aged ≥ 19 years were included. Urine dilution was corrected by the covariate-adjusted standardization (CAS) method. We performed meta-analysis, logistic regression analysis by matching all covariates with a 1:1 propensity score, and a 4-knot restricted cubic spline plot model to calculate the odds ratios (ORs) for obesity according to natural log-transformed BPA levels. Mean urinary BPA concentration was 1.12 µg/L in KoNEHS Cycle 2 and 1.32 µg/L in Cycle 3. BPA levels were significantly higher among obese adults than among non-obese adults in both KoNEHS Cycles 2 and 3. In pooled data of KoNEHS Cycles 2 and 3, BPA showed significant positive associations with ORs for obesity in both sexes, which were more prominent in females (linear) than in males (non-linear). These associations were confirmed in spline analyses. CAS-applied BPA concentrations were positively associated with obesity in nationwide representative samples of Korean adults. Further studies are warranted to confirm and elucidate the underlying mechanism.
A high-throughput cell-based assay pipeline for the preclinical development of bacterial DsbA inhibitors as antivirulence therapeutics
Authors: Verderosa Anthony D. , Dhouib Rabeb , Hong Yaoqin , Anderson Taylah K. , Heras Begoña , Totsika Makrina 
Published: January 2021

AbstractAntibiotics are failing fast, and the development pipeline remains alarmingly dry. New drug research and development is being urged by world health officials, with new antibacterials against multidrug-resistant Gram-negative pathogens as the highest priority. Antivirulence drugs, which inhibit bacterial pathogenicity factors, are a class of promising antibacterials, however, their development is stifled by lack of standardised preclinical testing akin to what guides antibiotic development. The lack of established target-specific microbiological assays amenable to high-throughput, often means that cell-based testing of virulence inhibitors is absent from the discovery (hit-to-lead) phase, only to be employed at later-stages of lead optimization. Here, we address this by establishing a pipeline of bacterial cell-based assays developed for the identification and early preclinical evaluation of DsbA inhibitors, previously identified by biophysical and biochemical assays. Inhibitors of DsbA block oxidative protein folding required for virulence factor folding in pathogens. Here we use existing Escherichia coli DsbA inhibitors and uropathogenic E. coli (UPEC) as a model pathogen, to demonstrate that the combination of a cell-based sulfotransferase assay and a motility assay (both DsbA reporter assays), modified for a higher throughput format, can provide a robust and target-specific platform for the identification and evaluation of DsbA inhibitors.
The response of zircon to the extreme pressures and temperatures of a lightning strike
Authors: Kenny Gavin G. , Pasek Matthew A. 
Published: January 2021

AbstractHypervelocity impacts can produce features in zircon that are not normally produced by endogenic processes. However, lightning can also induce extreme pressure–temperature excursions, and its effect on zircon has not been studied. With the aim to recognise features that form in response to extreme pressure–temperature excursions but are not unique to hypervelocity impacts, we imaged and undertook microstructural characterization of zircon in a fulgurite (a tubular body of glass and fused clasts that formed in response to a lightning strike). We document zircon with granular ZrO2and rims of vermicular ZrO2, features which vary in abundance with increasing distance from the fulgurite’s central void. This indicates that these features formed in response to the lightning strike. Zircon dissociation to ZrO2and SiO2is a high-temperature, relatively low-pressure phenomenon, consistent with previous suggestions that lightning strikes involve extreme temperatures as well as pressures greater than those usually generated in Earth’s crust but rarely > 10 GPa. The rims of monoclinic ZrO2record crystallographic evidence for precursor cubic ZrO2, demonstrating that cubic ZrO2is not unique to hypervelocity impacts. Given the likelihood that this fulgurite experienced pressures of, at most, a few GPa, evidence for cubic ZrO2indicates peak temperatures > 2000 °C.
Direct monitoring of the stepwise condensation of kinetoplast DNA networks
Authors: Yaffe Nurit , Rotem Dvir , Soni Awakash , Porath Danny , Shlomai Joseph 
Published: January 2021

AbstractCondensation and remodeling of nuclear genomes play an essential role in the regulation of gene expression and replication. Yet, our understanding of these processes and their regulatory role in other DNA-containing organelles, has been limited. This study focuses on the packaging of kinetoplast DNA (kDNA), the mitochondrial genome of kinetoplastids. Severe tropical diseases, affecting large human populations and livestock, are caused by pathogenic species of this group of protists. kDNA consists of several thousand DNA minicircles and several dozen DNA maxicircles that are linked topologically into a remarkable DNA network, which is condensed into a mitochondrial nucleoid. In vitro analyses implicated the replication protein UMSBP in the decondensation of kDNA, which enables the initiation of kDNA replication. Here, we monitored the condensation of kDNA, using fluorescence and atomic force microscopy. Analysis of condensation intermediates revealed that kDNA condensation proceeds via sequential hierarchical steps, where multiple interconnected local condensation foci are generated and further assemble into higher order condensation centers, leading to complete condensation of the network. This process is also affected by the maxicircles component of kDNA. The structure of condensing kDNA intermediates sheds light on the structural organization of the condensed kDNA network within the mitochondrial nucleoid.
Tough metal-ceramic composites with multifunctional nacre-like architecture
Authors: Poloni Erik , Bouville Florian , Dreimol Christopher H. , Niebel Tobias P. , Weber Thomas , Biedermann Andrea R. , Hirt Ann M. , Studart André R. 
Published: January 2021

AbstractThe brick-and-mortar architecture of biological nacre has inspired the development of synthetic composites with enhanced fracture toughness and multiple functionalities. While the use of metals as the “mortar” phase is an attractive option to maximize fracture toughness of bulk composites, non-mechanical functionalities potentially enabled by the presence of a metal in the structure remain relatively limited and unexplored. Using iron as the mortar phase, we develop and investigate nacre-like composites with high fracture toughness and stiffness combined with unique magnetic, electrical and thermal functionalities. Such metal-ceramic composites are prepared through the sol–gel deposition of iron-based coatings on alumina platelets and the magnetically-driven assembly of the pre-coated platelets into nacre-like architectures, followed by pressure-assisted densification at 1450 °C. With the help of state-of-the-art characterization techniques, we show that this processing route leads to lightweight inorganic structures that display outstanding fracture resistance, show noticeable magnetization and are amenable to fast induction heating. Materials with this set of properties might find use in transport, aerospace and robotic applications that require weight minimization combined with magnetic, electrical or thermal functionalities.
Non-local terahertz photoconductivity in the topological phase of Hg1−xCdxTe
Authors: Kazakov A. S. , Galeeva A. V. , Artamkin A. I. , Ikonnikov A. V. , Ryabova L. I. , Dvoretsky S. A. , Mikhailov N. N. , Bannikov M. I. , Danilov S. N. , Khokhlov D. R. 
Published: January 2021

AbstractWe report on observation of strong non-local photoconducitivity induced by terahertz laser pulses in non-zero magnetic field in heterostructures based on Hg1−xCdxTe films being in the topological phase. While the zero-field non-local photoconductivity is negligible, it is strongly enhanced in magnetic fields ~ 0.05 T resulting in appearance of an edge photocurrent that exceeds the respective dark signal by orders of magnitude. This photocurrent is chiral, and the chirality changes every time the magnetic field or the electric bias is reversed. Appearance of the non-local terahertz photoconductivity is attributed to features of the interface between the topological film and the trivial buffer.
Investigation on performance of particle swarm optimization (PSO) algorithm based fuzzy inference system (PSOFIS) in a combination of CFD modeling for prediction of fluid flow
Authors: Babanezhad Meisam , Behroyan Iman , Nakhjiri Ali Taghvaie , Marjani Azam , Rezakazemi Mashallah , Heydarinasab Amir , Shirazian Saeed 
Published: January 2021

AbstractHerein, a reactor of bubble column type with non-equilibrium thermal condition between air and water is mechanistically modeled and simulated by the CFD technique. Moreover, the combination of the adaptive network (AN) trainer with the fuzzy inference system (FIS) as the artificial intelligence method calling ANFIS has already shown potential in the optimization of CFD approach. Although the artificial intelligence method of particle swarm optimization (PSO) algorithm based fuzzy inference system (PSOFIS) has a good background for optimizing the other fields of research, there are not any investigations on the cooperation of this method with the CFD. The PSOFIS can reduce all the difficulties and simplify the investigation by elimination of the additional CFD simulations. In fact, after achieving the best intelligence, all the predictions can be done by the PSOFIS instead of the massive computational efforts needed for CFD modeling. The first aim of this study is to develop the PSOFIS for use in the CFD approach application. The second one is to make a comparison between the PSOFIS and ANFIS for the accurate prediction of the CFD results. In the present study, the CFD data are learned by the PSOFIS for prediction of the water velocity inside the bubble column. The values of input numbers, swarm sizes, and inertia weights are investigated for the best intelligence. Once the best intelligence is achieved, there is no need to mesh refinement in the CFD domain. The mesh density can be increased, and the newer predictions can be done in an easier way by the PSOFIS with much less computational efforts. For a strong verification, the results of the PSOFIS in the prediction of the liquid velocity are compared with those of the ANFIS. It was shown that for the same fuzzy set parameters, the PSOFIS predictions are closer to the CFD in comparison with the ANFIS. The regression number (R) of the PSOFIS (0.98) was a little more than that of the ANFIS (0.97). The PSOFIS showed a powerful potential in mesh density increment from 9477 to 774,468 and accurate predictions for the new nodes independent of the CFD modeling.
Influence of biopolymers on the rheological properties of seafloor sediments and the runout behavior of submarine debris flows
Authors: Kameda Jun , Yohei Hamada 
Published: January 2021

AbstractSubmarine debris flows are mass movement processes on the seafloor, and are geohazards for seafloor infrastructure such as pipelines, communication cables, and submarine structures. Understanding the generation and run-out behavior of submarine debris flows is thus critical for assessing the risk of such geohazards. The rheological properties of seafloor sediments are governed by factors including sediment composition, grain size, water content, and physico-chemical conditions. In addition, extracellular polymeric substances (EPS) generated by microorganisms can affect rheological properties in natural systems. Here we show that a small quantity of EPS (~ 0.1 wt%) can potentially increase slope stability and decrease the mobility of submarine debris flows by increasing the internal cohesion of seafloor sediment. Our experiments demonstrated that the flow behavior of sediment suspensions mixed with an analogue material of EPS (xanthan gum) can be described by a Herschel–Bulkley model, with the rheological parameters being modified progressively, but not monotonously, with increasing EPS content. Numerical modeling of debris flows demonstrated that the run-out distance markedly decreases if even 0.1 wt% of EPS is added. The addition of EPS can also enhance the resistivity of sediment to fluidization triggered by cyclic loading, by means of formation of an EPS network that binds sediment particles. These findings suggest that the presence of EPS in natural environments reduces the likelihood of submarine geohazards.
Increase in occurrence of large glacier-related landslides in the high mountains of Asia
Authors: Liu Jia , Wu Yuming , Gao Xing 
Published: January 2021

AbstractGlobally, a large number of glaciers are retreating due to global warming. Along with climate change, glacial melting has been identified as one of the main triggers of landslide activity in high mountain areas. Evaluations of the triggered mechanism alone do not provide comprehensive insight into the overall impact of glacier accumulation and ablation on landslide-induced denudation. To investigate recent trends, we built landslide and glacier datasets for the HMA using a Landsat time-series covering the past 21 years (1998–2018). Landslides that may have been caused by major earthquakes were identified and removed, leaving an inventory that is used to explore changes that may be related to climate change. Our results show a shift in the frequency–area distribution that indicates an increasing trend of large landslides in the HMA over the last decade. A decline in glacier area is associated with the increase in landslide area.
Variation of rhizosphere microbial community in continuous mono-maize seed production
Authors: Zhao Yunchen , Fu Wenjiang , Hu Changwei , Chen Guangquan , Xiao Zhanwen , Chen Yuru , Wang Zhijiang , Cheng Hongyu 
Published: January 2021

AbstractSoil microbe is crucial to a healthy soil, therefore its diversities and abundances under different conditions are still need fully understand.The aims of the study were to characterize the community structure and diversity of microbe in the rhizosphere soil after continuous maize seed production, and the relationship between the disease incidence of four diseases and the variation of the rhizosphere microbe. The results showed that different fungal and bacterial species were predominant in different cropping year, and long-term maize seed production had a huge impact on structure and diversity of soil microbial. Ascomycota and Mortierellomycota were the dominant fungal phyla and Mortierella and Ascomycetes represented for a large proportion of genus. A relative increase of Fusarium and Gibberella and a relative decrease of Mortierella, Chrysosporium, Podospora, and Chaetomium were observed with the increase of cropping year. Pathogenic Fusarium, Curvularia, Curvularia-lunata, Cladosporium, Gibberella-baccata, and Plectosphaerellaceae were over-presented and varied at different continuous cropping year, led to different maize disease incidence. Proteobacteria and Actinobacteria ranked in the top two of all bacterial phyla, and genus Pseudarthrobacter, Roseiflexus and RB41 dominated top 3. Haliangium and Streptomyces decreased with the continuous cropping year and mono-cropping of maize seed production increased disease incidence with the increase of cropping year, while the major disease was different. Continuous cropping of maize seed production induced the decrease of protective microbe and biocontrol genera, while pathogenic pathogen increased, and maize are in danger of pathogen invasion. Field management show great effects on soil microbial community.