bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards An Effective Collaboration Between South Western Sydney Local Health District and Local Councils: Insights From The Qualitative Study
Authors: Kovai Vilas , Mahjabeen Zeenat , Arjunan Punitha , Jalaludin Bin 
Published: June 2021

Abstract
Background

Urban planning is of fundamental use in promoting a healthy urban environment, prompting increased collaboration between public health and local government planning authorities. A major challenge to the success of this co-operation, however, is the difficulty of ensuring that the views of the health sector are, ultimately, reflected in planning policy. To facilitate this, a qualitative study was designed by Population Health, South Western Sydney Local Health District (SWSLHD) in 2016.
Objective

The aim of the study was to investigate ways in which SWSLHD could be engaged with councils in the urban planning processes of local councils in south-western Sydney to promote a healthy urban environment.
Methods

Qualitative data was collected from 14 in-depth interviews with staff representing five local councils: Bankstown, Camden, Liverpool, Campbelltown, and Fairfield. The data was thematically analysed using inductive and deductive reasoning by applying NVivo software.
Results

While councils recognise the potential value of consultation (and partnership) with SWSLHD, the fact is that the status quo is one of limited communication and the absence of any clearly defined process for collaboration. Councils perceive knowledge gaps in relation to basic issues such as who provides what services to whom and how to access services from health experts related to evidence based local government level data.
Implications:

The study demonstrated that a shift in provision of public health evidence that has local applicability in a timely manner on issues of mutual concern, and proactive and ongoing consultations between SWSLHD and councils would enable effective engagement, coordinated and sustained actions.
Adult Onset Alexander Disease Presenting as Psychogenic Polydipsia Induced Recurrent Hyponatremia as the Initial Symptom: A Case Report.
Authors: Li Honghao , Yu Jing , Guo Shougang 
Published: June 2021

Abstract
BackgroundAlexander disease (AxD, OMIM 203450) is a rare and generally fatal disorder of the central nervous system associated with heterozygous mutations in glial fibrillary acidic protein (GFAP) gene. Neuroradiological and clinical features of adult onset AxD is characterized by involvement of hindbrain structures. Psychiatric manifestations and extensive white matter lesions are very sparse in adult onset AxD.Case presentationWe diagnosed a female with AxD presenting with recurrent hyponatremia caused by psychogenic polydipsia as initial symptom at the onset age of 52-year-old. Neurological examination revealed slightly cognitive decline and brisk deep tendon reflex (DTR) in bilateral lower limbs. The symptoms commonly seen in adult onset AxD such as pseudobulbar signs, ataxia and spasticity were not found in the clinical course of disease. Her mother and elder brother had a history of schizophrenia. The patient has had a history of compulsive water drinking as well as personality change in recent years. Her brain magnetic resonance imaging (MRI) showed extensive involvement of white matter without atrophy of medulla oblongata and cervical spinal cord. The next generation DNA sequencing (NGS) showed a likely pathogenic nonsense mutation C1237C>T(pR413*) in GFAP-ε isoform.ConclusionsOur report enriches the understanding of familial adult onset AxD. Our case also contributes to evidence of pathogenicity of the variants in GFAP-ε as the cause of adult onset AxD.
Association Between Immune-Related Hypothyroidism and Survival Outcomes in Patients with Head and Neck Cancer Treated with Nivolumab
Authors: Hata Kojiro , Sasaki Keiichi , Watanabe Hiroyuki , Ikeda Munehiko , Tsuji Toshikazu , Ishida Shigeru , Ikebe Mio , Kumagai Ayako , Ozawa Nana , Matsukane Ryosuke , Nagata Kenichiro , Suetsugu Kimitaka , Tajima Soichiro , Yamada Takaaki , Egashira Nobuaki , Matsuo Mioko , Yasumatsu Ryuji , Nakagawa Takashi , Ieiri Ichiro 
Published: June 2021

Abstract
Background

Immune-related hypothyroidism (irHT) triggered by nivolumab is known to affect drug efficacy in patients with non-small cell lung cancer (NSCLC). However, it is unclear whether there is an association between the drug efficacy and nivolumab-induced irHT in recurrent and/or metastatic head and neck cancer (R/M HNC). Hence, we retrospectively investigated the relationship between irHT and treatment outcomes in R/M HNC patients treated with nivolumab.
Methods

Patients with R/M HNC who received nivolumab monotherapy between April 2017 and June 2019 were selected. Those receiving levothyroxine treatment and with thyroid-stimulating hormone (TSH) levels > 10 µIU/mL before nivolumab administration were excluded. irHT was defined as one measurement of free T4 (FT4) < 0.8 ng/dL and/or TSH > 10 µIU/mL or as two successive abnormal levels of FT4 and/or TSH after nivolumab administration. To assess therapeutic efficacy, nivolumab-treated patients were divided into two groups: with or without irHT [irHT (+) and irHT (−) groups, respectively].
Results

Of the 31 nivolumab-treated patients, 14 developed irHT. The median time to onset was 76 days (17–274 days). The median overall survival was 704 days (95% confidence interval [CI], 223–not reached) in the irHT (+) group and 244 days (95% CI, 170–342) in the irHT (−) group (hazard ratio (HR) = 0.33, p = 0.0259). The median progression-free survival was 197 days (95% CI, 103–not reached) in the irHT (+) group and 105 days (95% CI, 52–151) in the irHT (−) group (HR = 0.32, p = 0.0115). The disease control rate was significantly higher in the irHT (+) group than in the irHT (−) group (78.6% vs. 35.3%; p = 0.0292). Although there was no difference in the incidence of grade 3 serious immune-related adverse events (irAEs) between the two groups, the incidence of multiple irAE events in each patient (50.0% vs. 5.9%; p = 0.0109) was significantly higher in the irHT (+) group than that in the irHT (−) group.
Conclusions

Our results suggest that the development of irHT, similarly to NSCLC, is associated with improved survival outcomes in R/M HNC patients treated with nivolumab.
Error Identification Method of Five-Axis Machine Tool Based on Sample Test Method
Authors: Lv xuehu , Guo qianjian , Yuan wei , Wang wenhua , Zhu yuqi , Wang haotian 
Published: June 2021

Abstract
In order to improve the predictive ability of the error model of the five-axis machine tool, an indirect error measurement (IEM) method of the five-axis machine tool based on the sample test method was proposed, and the optimized design of the stepped axis sample was completed. By inversely calculating the spatial error model of the machine tool, the function analysis relationship between the sample machining error and different error terms of the machine tool was established, and then the dynamic errors of the machine tool in different machining states were obtained. The reliability and practical effects of the method was verified through experiments. The results showed that the proposed IEM method was in good agreement with the laser measurement method. The predictive ability of the error model of the five-axis machine tool can be improved by using the IEM method, thereby more machining accuracy of the machine tool will be ensured.
Flood Hazard Mapping Using Exploratory Regression Model in GIS Domain
Authors: Ahmad Imran , Fenta Assefa , Dar Mithas , Halefom Afera , Tashome Aseret , Andualem tesfa 
Published: June 2021

Abstract
In this study, attempt has been made to understand the spatial distribution of flood hazard and flood risk in the Awash basin, Ethiopia. Awash basin has been chosen because it’s in continuous threat spatially and temporally. Eight determinant factors of flood hazard (viz., elevation, slope, rainfall, drainage density, landuse, soil type, wetness index and lineament density) were studied as independent variables. Each factor was reclassified into four classes and each was weighted according to its susceptibility towards the hazard. For example topographic lows were given the highest weight of 4; whereas topographic highs were given the lowest weight of 1. All the independent variables were overlaid in GIS domain to get the final spatial distribution of hotspots of flood hazard. Exploratory regression analysis showed that the existing landuse is the dominant factor influencing the flood vulnerability. A total of 31 models were generated using Exploratory regression in GIS domain. Model number 31 was found to be the best fit model with the highest Adjusted R2 value of 0.839539 and the least Akaike’s Information criterion value of 1536.866. Spatial autocorrelation tool run on the standard residuals yields the Z score and p value of 0.742522 and 0.457771 respectively; indicating that the residuals were neither clustered nor dispersed. Spatial extents of flood hazard and flood risk along with the priority for spatial planning in the Awash basin is digested well in this study.
Does Financial Toxicity Exist Amongst Adult Cancer Survivors Treated with Curative-Intent Radiotherapy? A Pilot Study from Singapore
Authors: Ng Ivy Weishan , Yuen Kah Hung , Meng Tian , Tan Chuan Chien , Yeo Chong Ming , Tey Chee Seong Jeremy , Soon Yu Yang , Ho Cho Hao Francis , Yoong Su-Yin Joanne , Gibbons Brent , Vellayappan Balamurugan A 
Published: June 2021

Abstract
Background

Cancer survivors may experience financial toxicity (FT) arising from diagnosis, treatµent, and potential employment loss. The prevalence of FT in the context of Singapore healthcare model is unknown. We investigate if higher out of pocket (OOP) expenditure correlates positively with FT, and if higher FT correlates with a worse quality of life (QoL).
Methods

In this pilot study, a cross-sectional survey was administered to survivors of nasopharyngeal or breast cancer, at National University Hospital Singapore. Patients’ FT and QOL were measured using the COmprehensive Score on financial Toxicity (COST) and Functional Assessment of Cancer Therapy: General (FACT-G). Two multivariate regression models estimated (i) the association between FT and a range of variables and (ii) FT and QOL.
Results

63% of our cohort of 76 patients experienced mild-moderate FT. Overall, the mean COST and FACT-G scores are 18.0 (out of 44) and 68.3 (out of 108), respectively. There was a positive correlation between COST and FACT-G scores (r = 0.45). We did not find any significant association between OOP and FT. Predictors for FT included government-subsidized housing, lower education levels, hiring a formal caregiver, and the need for household members to take on extra employment.
Conclusion

Greater FT correlates with a decline in QoL. Lower socio-economic patients are at higher risk of FT. OOP was not directed related to FT, likely in view of the effective means-tested subsidies. Additional resources should be considered for this at-risk population. Based on our pilot study, our methodology to quantify FT and OOP can be scaled up to other cancer primaries.
Ecosystem Services Assessment, Trade-Off and Bundles in the Yellow River Basin, China
Authors: Yang Jie , Xie Baopeng , Tao Wenqian 
Published: June 2021

Abstract

Understanding ecosystem services (ESs) and their interactions will help to formulate effective and sustainable land use management programs.This paper evaluates the water yield (WY), soil conservation (SC), carbon storage (CS) and habitat quality (HQ), taking the Yellow River Basin as the research object, by adopting the InVEST (Integrated Valuation of Ecosystem Services and Trade Offs) model. The Net Primary Productivity (NPP) was evaluated by CASA (Carnegie-Ames-Stanford approach) model, and the spatial distribution map of five ESs were drawn, the correlation and bivariate spatial correlation were used to analyze the trade-off synergy relationships between the five ESs and express them spatially. The results show that NPP and HQ, CS and WY are trade-offs relationship, and other ecosystem services are synergistic. The trade-off synergy shows obvious spatial heterogeneity. Driven by different factors, the leading ecological function services in the Yellow River Basin can be divided into three areas, and WY and SC service leading functional areas are mainly distributed in HQ and CS service leading functional areas and NPP service leading functional areas.The results of functional bundles are obviously affected by natural conditions such as land use/cover types and climate in the Yellow River Basin, which can provide the basis for the Yellow River Basin to regulate ESs and maximize benefits.
Transdisciplinarity of India's Master's Level Public Health Programmes: Evidence from Admission Criteria of the Programmes Offered Since 1995
Authors: Ilangovan Kumaravel , Muthappan Sendhilkumar , Govindarajan Keerthiga , Vairamani Vignesh , Venkatasamy Vettrichelvan , Ponnaiah Manickam 
Published: June 2021

Abstract
Background
In Indian subcontinent, Master's level public health (MPH) programmes attract graduates of diverse academic disciplines from health and non-health sciences alike. Considering the current and futuristic importance of the public health cadre, we described them and reviewed their transdisciplinarity status based on MPH admissibility criteria 1995 to 2021.
Methods
Using a search strategy, we abstracted information available in the public domain on MPH and their admissibility criteria. We classified disciplines specified for admission into Science, Social sciences and Arts, Health and Non-health categories. We described the MPH programmes by location, type of institutions, course duration, pedagogical methods, specialisations offered, and nature of admission criteria statements. We calculated descriptive statistics for eligible educational qualifications for admission to MPH programmes.
Results
Overall, 74 Indian institutions offered 88 MPH programmes. We included 85 for review. These programmes represent 50% increase (n = 44) from that of 2016-17. They are mostly concentrated in 21 provinces and union territories of India. These programmes stated that they admit candidates of but not limited to "graduation in any life sciences", "three-year bachelors degree in any discipline", “graduation from any Indian universities”, and "graduation in any discipline". Of the 72 institutions, 14 admit multidisciplinary academic graduates in their 16 programmes. Except three institutions from public sector, 69 provide MPH admission opportunities to multidisciplinary health and non-health academic graduates.
Conclusion
Our review suggests that India's MPH programmes are less transdisciplinary. India's Master's level public health programmes should transcend to be more inclusive and admit graduates of various academic educational backgrounds.
Analysis and Real-Time Implementation of IoT in Autism
Authors: Afzal Muhammad Javaid , Ashraf Muhammad Waseem , Tayyaba Shahzadi , Javaid Farah 
Published: June 2021

Abstract
The present study comprises the importance and use of IoT, smart home, peer-to-peer, and some other different technologies for the betterment of mankind. Artificial intelligence and machine learning are becoming more and more popular in IoT-based smart homes and other techs. The IoT framework has been used to provide a predictable, concrete, and self-paced learning environment and encourages excellent visual information processing. These techs are also useful for special children with autism. They need smart homes, peer-to-peer networking, robot therapy, and wearable techs. In this paper, the authors presented a unique FLC simulation for the behavior of a child with moderate autism. This simulation shows that how IoT, smart home, peer-to-peer technology, ABA therapy, robot therapy, and wearable techs can bring comforts in the life of a child with autism. All of them have long lasted impacts in producing social skills in an ASD person. The 3D graphical figures presented the graphical analysis of a child’s social behavior. The simulation presented 50% betterment change in the social behavior of children and this can be increased up to 87% by using intensive therapies. It is also verified by Mamdani’s method. A real-time implementation of a boy with autism has shown significant improvements in his social skills.
Gene-Based Association Tests Using GWAS Summary Statistics and Incorporating eQTL
Authors: Cao Xuewei , Wang Xuexia , Zhang Shuanglin , Sha Qiuying 
Published: June 2021

Abstract
Although genome-wide association studies (GWAS) have been successfully applied to a variety of complex diseases and identified many genetic variants underlying complex diseases, there is still a considerable heritability of complex diseases that could not be explained by GWAS. One alternative approach to overcome the missing heritability caused by the genetic heterogeneity is gene-based analysis, which considers the aggregate effects of multiple genetic variants in a single test. Another alternative approach is transcriptome-wide association study (TWAS). TWAS aggregates genomic information into functionally relevant units that map to genes and their expression. TWAS is not only powerful, but can also increase the interpretability in biological mechanisms of identified trait associated genes. In this study, we propose two powerful and computationally efficient gene-based association tests, Overall and Copula. These two tests aggregate information from three traditional types of gene-based association tests and also incorporate expression quantitative trait locus (eQTL) data into GWAS using GWAS summary statistics. Overall utilizes the extended Simes procedure and Copula utilizes the Gaussian copula approximation-based method. We show that after a small number of replications to estimate the correlation among the integrated gene-based tests, the P values of these two methods can be calculated analytically. Simulation studies show that these two tests can control type I error rate very well and have higher power than the tests that we compared. We also apply these two methods to two schizophrenia GWAS summary datasets and two lipids GWAS summary datasets. The results show that these two newly developed methods can identify more significant genes than other methods we compared with.
Validation of a Redundant Robotic Manipulator for Shoulder in Vitro Biomechanical Testing.
Authors: Moissenet Florent , Rastoll Clément , Gonzalez David , Foukia Noria , Lauria Michel , Armand Stéphane , Beaulieu Jean-Yves , Holzer Nicolas 
Published: June 2021

Abstract
Cadaveric joint simulators are commonly used to explore native and pathological joint function as well as to test medical devices. Recently, robotic manipulators have been proposed as a new gold standard for in vitro biomechanical testing as they offer higher possibilities than Universal Testing Machines in terms of degrees of freedom (DOF). However, current protocols remain conducted in extra-corporal conditions by fixing one segment of a diarthrodial joint while mobilising the other segment. Moreover, induced motions are commonly not specimen-specific and do not respect related joint kinematic constraints and physiologic boundaries. In this study, using a 7 DOF redundant robotic manipulator, an intra-corporal condition protocol was defined. This protocol allows 1) the analysis of the shoulder girdle full kinematic chain, 2) the replication of specimen-specific humerus motions initially induced by an operator. On the 10 shoulders tested, the robotic manipulator was able to perform requested end-effector motions with a reliability of 0.28 ± 0.57 mm and 0.15 ± 0.25°, and a fidelity of 0.27 ± 0.56 mm and 0.22 ± 0.28°. This protocol will be used in the future to explore joint function as well as to test medical devices, on the shoulder girdle and potentially other joints.
Patients with Borderline and Avoidant Personality Disorders in the Pandemic Their Mental Distress During the Covid-19 Crisis in Norway
Authors: Zahl Kjell-Einar , Pedersen Geir , Eikenaes Ingeborg Ulltveit-Moe , Stänicke Line Indrevoll , Wilberg Theresa , Baltzersen Åse-Line , Pettersen Mona , Hummelen Benjamin , Arnevik Espen , Johansen Merete Selsbakk , Kvarstein Elfrida Hartveit 
Published: June 2021

Abstract
Background

Even if people with mental disorders are vulnerable, few authors have studied patients with personality disorders (PDs) in the pandemic. We wanted to examine and compare mental and social distress among patients with borderline PD (BPD) and avoidant PD (AvPD) during the first wave of Covid-19.
Methods

In Summer 2020 a survey was distributed to 1120 patients referred to PD treatment units in Norway, with questions on social situation, mental distress, and changes in mental health after the lockdown. Among 133 responders we studied 40 patients with BPD and 30 with AvPD as their only PD.
Results

70% of the patients in both groups were more alone than before the pandemic, more than 40% felt lonelier, and 50% more aggressive. Both PD groups reported high levels of depression and anxiety, many with suicidal thoughts, and worries about health issues. Several BPD patients reported an improvement in some issues compared to the AvPD patients, with more initiative and energy.
Conclusions

Both PD groups reported increased levels of distress in the first wave of the pandemic. AvPD patients were not less distressed in their social isolation, but a significant group of BPD patients reported less distress in the first months of the pandemic.
Cubic 3D Chern photonic insulators with orientable large Chern vectors
Authors: Devescovi Chiara , Garcia-Diez Mikel , Robredo Iñigo , de Paz Maria Blanco , Bradlyn Barry , Mañes Juan Luis , Vergniory Maia , Garcia-Etxarri Aitzol 
Published: June 2021

Abstract
Time Reversal Symmetry (TRS) broken topological phases provide gapless surface states protected by topology, regardless of additional internal symmetries, spin or valley degrees of freedom. Despite the numerous demonstrations of 2D topological phases, few examples of 3D topological systems with TRS breaking exist. In this article, we devise a general strategy to design 3D Chern insulating (3D CI) cubic photonic crystals in a weakly TRS broken environment with orientable and arbitrarily large Chern vectors. The designs display topologically protected chiral and unidirectional surface states with disjoint equifrequency loops. The resulting crystals present the following novel characteristics: First, by increasing the Chern number, multiple surface states channels can be supported. Second, the Chern vector can be oriented along any direction simply changing the magnetization axis, opening up larger 3D CI/3D CI interfacing possibilities as compared to 2D. Third, by lowering the TRS breaking requirements, the system is ideal for realistic photonic applications where the magnetic response is weak.