bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Review on the Developments of Peridynamics for Reinforced Concrete Structures
Authors: Hattori Gabriel , Hobbs Mark , Orr John 
Published: February 2021

AbstractConcrete is the most widely used man made material in the world. Reinforced with steel, it forms a key enabler behind our rapidly urbanising built environment. Yet despite its ubiquity, the failure behaviour of the material in shear is still not well understood. Many different shear models have been proposed over the years, often validated against sets of physical tests, but none of these has yet been shown to be sufficiently general to account for the behaviour of all possible types and geometries of reinforced concrete structures. A key barrier to a general model is that concrete must crack in tension, and in shear such cracks form rapidly to create brittle failure. Peridynamics (PD) is a non-local theory where the continuum mechanics equilibrium equation is reformulated in an integral form, thereby permitting discontinuities to arise naturally from the formulation. On the one hand, this offers the potential to provide a general concrete model. On the other hand, PD models for concrete structures have not focussed on applications with reinforcement. Moreover, a robust model validation that assesses the strengths and weakness of a given model is missing. The objectives of this paper are twofold: (1) to evaluate the benchmark tests involving shear failure for RC structures; and (2) to review the most recent PD theory and its application for reinforced concrete (RC) structures. We investigate these models in detail and propose benchmark tests that a PD model should be able to simulate accurately.
Expanding Research Integrity: A Cultural-Practice Perspective
Authors: Valkenburg Govert , Dix Guus , Tijdink Joeri , de Rijcke Sarah 
Published: February 2021

AbstractResearch integrity(RI) is usually discussed in terms of responsibilities that individual researchers bear towards the scientific work they conduct, as well as responsibilities that institutions have to enable those individual researchers to do so. In addition to these two bearers of responsibility, a third category often surfaces, which is variably referred to ascultureandpractice. These notions merit further development beyond a residual category that is to contain everything that is not covered by attributions to individuals and institutions. This paper discusses how thinking in RI can take benefit from more specific ideas on practice and culture. We start by articulating elements of practice and culture, and explore how values central to RI are related to these elements. These insights help identify additional points of intervention for fostering responsible conduct. This helps to build “cultures and practices of research integrity”, as it makes clear that specific times and places are connected to specific practices and cultures and should have a place in the debate on Research Integrity. With this conceptual framework, practitioners as well as theorists can avoid using the notions as residual categories that de facto amount to vague, additional burdens of responsibility for the individual.
Biomarkers in Hereditary Angioedema
Authors: Porebski Grzegorz , Kwitniewski Mateusz , Reshef Avner 
Published: February 2021

AbstractA biomarker is a defined characteristic measured as an indicator of normal, biologic, pathogenic processes, or biological responses to an exposure or intervention. Diagnostic biomarkers are used to detect a disease or a subtype of a disease; monitoring biomarkers are measured serially to assess a medical condition; response biomarkers are used to check biologic response following a medical intervention; predictive biomarkers are used to identify patients who are more likely to respond to a medical intervention; and prognostic biomarkers are used to assess the future likelihood of a clinical event. Although biomarkers have been extensively investigated and validated in many diseases and pathologies, very few are currently useful for the diagnosis, evaluation of disease activity, and treatment of hereditary angioedema (HAE). Pathophysiologic pathways involved in HAE reveal a plethora of molecules from the complement, coagulation, and fibrinolysis systems or from the vascular endothelium, which may serve as biomarkers. The most promising candidates, together with their laboratory readout systems, should be evaluated with regard to their analytical and clinical validity and utility. To be highly specific, such biomarkers should be linked to the pathomechanisms of HAE, particularly the bradykinin-generating cascade. Additionally, major advances in high-throughput omics-based technologies may facilitate the discovery of new candidate biomarkers in the future. This review will cover the existing as well as future potential biomarkers that will support the diagnosis, monitor disease activity, and can be used to assess the efficacy of new avenues of therapy of HAE and other forms of angioedema.
Typology of murder-suicides in Berlin according to a longitudinal study based on autopsy files
Authors: Zimmermann Milan , Tsokos Michael 
Published: February 2021

Abstract

Murder-suicides are defined as the murder of at least one person and the suicide of the offender following the murder. The intention to commit suicide must be primary. In most cases, a male offender kills a female victim after a separation. The current analysis was the first analysis of the typology of murder-suicides in Berlin. We analyzed the autopsy files of the Institute for Forensic Medicine of the Charité University Medicine Berlin and of the City Institute for Forensic Medicine Berlin. We performed descriptive and statistical analyses of cases between 2005 and 2013. We identified 17 murder-suicides. All 17 offenders were male, and 20 of the victims (90%) were female. The offenders used firearms in the majority of the cases. In seven cases, the victims and offenders were at least 80 years old. The average age of the offenders was 63 years. Disease was the motive in 6 cases involving older offenders. Our study might support the development of prevention strategies. In this regard, it is important to build a database for murder-suicides in Germany and other countries, to formulate a uniform definition of murder-suicide, to carry out nationwide interdisciplinary studies on this topic and to improve the existing health care structures, especially for older adults and people with depression.
Detecting and mitigating cyberattacks using software defined networks for integrated clinical environments
Authors: Huertas Celdrán Alberto , Karmakar Kallol Krishna , Gómez Mármol Félix , Varadharajan Vijay 
Published: February 2021

AbstractThe evolution of integrated clinical environments (ICE) and the future generations of mobile networks brings to reality the hospitals of the future and their innovative clinical scenarios. The mobile edge computing paradigm together with network function virtualization techniques and the software-defined networking paradigm enable self-management, adaptability, and security of medical devices and data management processes making up clinical environments. However, the logical centralized approach of the SDN control plane and its protocols introduce new vulnerabilities which affect the security of the network infrastructure and the patients’ safety. The paper at hand proposes an SDN/NFV-based architecture for the mobile edge computing infrastructure to detect and mitigate cybersecurity attacks exploiting SDN vulnerabilities of ICE in real time and on-demand. A motivating example and experiments presented in this paper demonstrate the feasibility of of the proposed architecture in a realistic clinical scenario.
Investigating the Association Between Celebrity Worship and Heteronormative Attitudes Among Heterosexual and LGB+ Individuals
Authors: Zsila Ágnes , Orosz Gábor , McCutcheon Lynn E. , Demetrovics Zsolt 
Published: February 2021

AbstractEvidence was found that perceived similarity with a famous person in gender, age, cultural background and attitudes increases the attraction towards this celebrity. Previous studies have also revealed that sexual minority individuals and those with a sexual attraction towards a famous person of the opposite gender are more likely to become obsessed with their favorite celebrity. Based on these findings, this study aimed to explore how heteronormative attitudes—gender role and behavioral expectations for men and women—are associated with celebrity worship in LGB+ and heterosexual individuals. An online questionnaire was administered to 1,763 Hungarian adults (66.4% male, 14.7% LGB+ individuals, Mage = 37.2 years, SD = 11.4). Heterosexual individuals with a favorite celebrity of the same gender reported stronger heteronormative attitudes in terms of gender roles and behaviors than LGB+ individuals. Furthermore, this aspect of heteronormative attitudes predicted higher levels of celebrity worship in individuals with a favorite celebrity of their own gender, irrespective of sexual orientation. However, heteronormative attitudes explained only a small proportion of the variance of celebrity worship (1–6%), indicating that heteronormativity has no substantial impact on celebrity admiration.
Evaluation of the Safety and Immune Efficacy of Recombinant Human Respiratory Syncytial Virus Strain Long Live Attenuated Vaccine Candidates
Authors: Wang Li-Nan , Peng Xiang-Lei , Xu Min , Zheng Yuan-Bo , Jiao Yue-Ying , Yu Jie-Mei , Fu Yuan-Hui , Zheng Yan-Peng , Zhu Wu-Yang , Dong Zhong-Jun , He Jin-Sheng 
Published: February 2021

AbstractHuman respiratory syncytial virus (RSV) infection is the leading cause of lower respiratory tract illness (LRTI), and no vaccine against LRTI has proven to be safe and effective in infants. Our study assessed attenuated recombinant RSVs as vaccine candidates to prevent RSV infection in mice. The constructed recombinant plasmids harbored (5′ to 3′) a T7 promoter, hammerhead ribozyme, RSV Long strain antigenomic cDNA with cold-passaged (cp) mutations or cp combined with temperature-sensitive attenuated mutations from the A2 strain (A2cpts) or further combined with SH gene deletion (A2cptsΔSH), HDV ribozyme (δ), and a T7 terminator. These vectors were subsequently co-transfected with four helper plasmids encoding N, P, L, and M2-1 viral proteins into BHK/T7-9 cells, and the recovered viruses were then passaged in Vero cells. The rescued recombinant RSVs (rRSVs) were named rRSV-Long/A2cp, rRSV-Long/A2cpts, and rRSV-Long/A2cptsΔSH, respectively, and stably passaged in vitro, without reversion to wild type (wt) at sites containing introduced mutations or deletion. Although rRSV-Long/A2cpts and rRSV-Long/A2cptsΔSH displayed temperature-sensitive (ts) phenotype in vitro and in vivo, all rRSVs were significantly attenuated in vivo. Furthermore, BALB/c mice immunized with rRSVs produced Th1-biased immune response, resisted wtRSV infection, and were free from enhanced respiratory disease. We showed that the combination of ΔSH with attenuation (att) mutations of cpts contributed to improving att phenotype, efficacy, and gene stability of rRSV. By successfully introducing att mutations and SH gene deletion into the RSV Long parent and producing three rRSV strains, we have laid an important foundation for the development of RSV live attenuated vaccines.
Esthetic and Functional Improvement of Asymmetric Lower Limb Overgrowth in a Proteus Syndrome Patient: a Combined Surgical Technique
Authors: Riccardi Francesca , Catapano Simone , Cottone Giuseppe , Zilio Dino , Vaienti Luca 
Published: February 2021

AbstractProteus syndrome is a rare, sporadic, congenital syndrome that causes asymmetric and disproportionate overgrowth of limbs, connective tissue nevi, epidermal nevi, alteration of adipose tissue, and vascular malformations. Genetic mosaicism, such as activating mutations involving protein kinase AKT1, phosphoinositide 3 kinase (PI3-K), and phosphatase and tensin homolog (PTEN), may be important causes of Proteus syndrome. However, many patients have no evidence of mutations in these genes. Currently, the diagnosis is clinical and based on phenotypic features. This article reports a case of Proteus syndrome in a 14-year-old female patient who presented with linear epidermal nevi, viscera anomalies, and adipose tissue dysregulation. She showed an asymmetric progressive overgrowth of the right lower limb after birth bringing relevant functional and esthetic consequences. Therefore, she asked a plastic surgery consultation and a surgical treatment with a combined technique was planned. With our approach, we were able to reduce leg diameter and improve joint mobility reliably and safely with satisfying esthetic results.
Immunohistochemical detection of procalcitonin in fibrolamellar hepatocellular carcinoma
Authors: Matsumoto Kotaro , Kikuchi Kentaro , Hara Ayako , Tsunashima Hiromichi , Tsuneyama Koichi , Doi Shinpei 
Published: February 2021

AbstractA 25-year-old woman with fever and epigastric pain was referred to our hospital. Blood examination showed significant liver dysfunction, markedly high C-reactive protein (CRP 19.1 mg/dL) and procalcitonin (48.3 ng/mL) levels. Dynamic computed tomography showed a tumor approximately 120 mm in size in the right lobe of the liver, but with no abscess formation. The patient was hospitalized and started on antibiotics; her CRP level improved, but the procalcitonin level did not decrease. Histopathological examination of the liver tumor biopsy revealed fibrolamellar hepatocellular carcinoma (FLC). Positive staining of the FLC with an anti-procalcitonin antibody suggested the production of procalcitonin.
A Meta-analysis on Children’s Trust in Social Robots
Authors: Stower Rebecca , Calvo-Barajas Natalia , Castellano Ginevra , Kappas Arvid 
Published: February 2021

AbstractAlthough research on children’s trust in social robots is increasingly growing in popularity, a systematic understanding of the factors which influence children’s trust in robots is lacking. In addition, meta-analyses in child–robot-interaction (cHRI) have yet to be popularly adopted as a method for synthesising results. We therefore conducted a meta-analysis aimed at identifying factors influencing children’s trust in robots. We constructed four meta-analytic models based on 20 identified studies, drawn from an initial pool of 414 papers, as a means of investigating the effect of robot embodiment and behaviour on both social and competency trust. Children’s pro-social attitudes towards social robots were also explored. There was tentative evidence to suggest that more human-like attributes lead to less competency trust in robots. In addition, we found a trend towards the type of measure that was used (subjective or objective) influencing the direction of effects for social trust. The meta-analysis also revealed a tendency towards under-powered designs, as well as variation in the methods and measures used to define trust. Nonetheless, we demonstrate that it is still possible to perform rigorous analyses despite these challenges. We also provide concrete methodological recommendations for future research, such as simplifying experimental designs, conducting a priori power analyses and clearer statistical reporting.
A secure and efficient privacy-preserving data aggregation algorithm
Authors: Dou Hui , Chen Yuling , Yang Yixian , Long Yangyang 
Published: February 2021

AbstractAs a significant part of the Internet of things, wireless sensor networks (WSNs) is frequently implemented in our daily life. Data aggregation in WSNs can realize limited transmission and save energy. In the process of data aggregation, node data information is vulnerable to be eavesdropped and attacked. Therefore, it is of great significance to the research of data aggregation privacy protection in WSNs. We propose a secure and efficient privacy-preserving data aggregation algorithm (SECPDA) based on the original clustering privacy data aggregation algorithm. In this algorithm, we utilize SEP protocol to dynamically select cluster head nodes, introduce slicing idea for the private data slicing, and generate false information for interference. A comprehensive experimental evaluation is conducted to assess the data traffic and privacy protection performance. The results demonstrate that the proposed SECPDA algorithm can effectively reduce data traffic and further improve data privacy of nodes.
Rethinking resilience and development: A coevolutionary perspective
Authors: Haider L. Jamila , Schlüter Maja , Folke Carl , Reyers Belinda 
Published: February 2021

AbstractThe interdependence of social and ecological processes is broadly acknowledged in the pursuit to enhance human wellbeing and prosperity for all. Yet, development interventions continue to prioritise economic development and short-term goals with little consideration of social-ecological interdependencies, ultimately undermining resilience and therefore efforts to deliver development outcomes. We propose and advance a coevolutionary perspective for rethinking development and its relationship to resilience. The perspective rests on three propositions: (1) social-ecological relationships coevolve through processes of variation, selection and retention, which are manifest in practices; (2) resilience is the capacity to filter practices (i.e. to influence what is selected and retained); and (3) development is a coevolutionary process shaping pathways of persistence, adaptation or transformation. Development interventions affect and are affected by social–ecological relationships and their coevolutionary dynamics, with consequences for resilience, often with perverse outcomes. A coevolutionary approach enables development interventions to better consider social–ecological interdependencies and dynamics. Adopting a coevolutionary perspective, which we illustrate with a case on agricultural biodiversity, encourages a radical rethinking of how resilience and development are conceptualised and practiced across global to local scales.
Integrability structures of the generalized Hunter–Saxton equation
Authors: Morozov Oleg I. 
Published: February 2021

AbstractWe consider integrability structures of the generalized Hunter–Saxton equation. We obtain the Lax representation with non-removable spectral parameter, find local recursion operators for symmetries and cosymmetries, generate an infinite-dimensional Lie algebra of higher symmetries, and prove existence of infinite number of cosymmetries of higher order. Further, we give examples of employing the higher order symmetries to constructing exact globally defined solutions for the generalized Hunter–Saxton equation.
Practices of Supportive Church Children's Ministries: An Exploratory Multilevel Investigation of Church of the Nazarene Congregations in the United States
Authors: Crosby Robert G. , Smith Erin I. , LaChausse Robert G. , Blanchette Leon , Palardy Gregory J. 
Published: February 2021

Background Religious communities have been identified as an important source of social support for children. Although church children's ministries (i.e., church programs where children receive religious education separate from their parents) have been suggested as a potential avenue for the transmission of social support, the specific children's ministry practices that promote social support have not been established empirically. Purpose The purpose of the present study was to determine whether contemplative-reflective practices, structured playtime, and unstructured playtime predict between-church differences in children's church-based social support (i.e., received support, perceived support from peers, perceived support from adults) controlling for children's individual characteristics and children's ministry size. Methods Using a multilevel approach, we analyzed self-report survey data from 43 children's ministers and 1,090 children from 43 Church of the Nazarene congregations in the United States. Results Results showed that children's supportive experiences were largely predicted by their individual characteristics (e.g., family religiosity, agreeableness). However, contemplative-reflective practices had a medium positive effect on received support and perceived support from peers and adults. Unstructured playtime had a medium positive effect on received support only. Structured playtime was unrelated to all three outcomes. Conclusions and Implications These findings suggest that, although some children are naturally predisposed to thrive socially at church, children's ministry practices appear to have a significant and substantive impact on children's church-based social support. The results shed light on the conditions that create and sustain church-based social support. Churches wishing to make children feel part of a supportive community should consider incorporating contemplative-reflective practices into their children's worship service (e.g., mindful prayer and reflective experiences, meaningful choices, leadership opportunities for children, safe and intimate opportunities to share and receive prayer, and liturgical traditions), as well as regular space for unstructured playtime wherein children can exercise autonomy, demonstrate their unique talents and abilities, and engage in informal conversations with peers and adults about their life experiences, feelings, and personal problems.
Gold hard anodized (GHA) materials with antimicrobial surface properties: mechanical, tribological, and microbiological characterization
Authors: Nastruzzi Anna , Cicerchia Franco , Fortini Annalisa , Nastruzzi Claudio 
Published: February 2021

AbstractInfections acquired in public spaces (i.e., transports, restaurants, and bars, hospitals) present a serious burden for the entire health systems. In this respect, appropriate preventative and control measures in order to eliminate or reduce the negative effects of surface-transmitted infections appear highly desirable. Alongside recommendations for treatment and hygiene, antimicrobial material surfaces can offer indeed an important contribution to the prevention of infections. The aim of the current paper is therefore to describe the preparation and characterization of a new material obtained by an innovative anodic oxidation, defined as golden hard anodizing GHA. The anodic oxide surface thanks to the nanoporous structure acts as reservoir of silver ions (Ag+) which in turn confer antimicrobial properties to the material surface. Specifically, the manuscript presents a thorough preparation and characterization of a new material obtained by an innovative anodic oxidation treatment applied on commercially available aluminum alloys including the microscopic analysis and the description of the antimicrobial performances against a number of microorganisms, including among the others, Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. More specifically, the current article describes some of the properties of GHA materials. The tribological properties of GHA were evaluated through experimental tests performed with a pin-on-disk tribometer. The morphology of the wear surfaces was studied by means of a scanning electron microscope (SEM) analysis and profilometry investigations. Furthermore, in order to evaluate the possible anticorrosive properties of GHA, tests in neutral salt spray are in addition described.