bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbial Assessment of Herbal Tea Production with Natural Ingredients
Authors: Deha C. I. , Fraikue F. B. , Twum N. , Abanga G. 
Published: December 2024

Purpose: The study aimed to assess the microbial safety and quality of herbal tea production using natural ingredients. The objectives of the research were to: determine the sensory characteristics of herbal tea produced using lemongrass, cloves, “precise”, and negro pepper. To evaluate critical control points for microbial contamination.
Design/Methodology/Approach: The study employed an experimental research design with staff from the Western Regional House of Chiefs as the population. A sample size of one hundred (100) respondents was selected for the study using purposive and convenience sampling methods. The sensory evaluation utilised a 7-point hedonic scale, whilst mineral content and proximate analysis were conducted. Analysis of Variance (ANOVA) was employed to evaluate differences among the various tea samples.
Findings: Participants showed a strong preference for Lemongrass (201) and Basic tea (204) due to their delightful taste experience, which encompassed appealing attributes such as colour, aroma, texture, and aftertaste. The investigation revealed notable differences in the nutrient composition of the herbal tea samples. Cloves (202) stood out for its higher protein and fat contents, with the highest counts of both aerobic microorganisms and yeast and molds, while Lemongrass was found to have more fibre and carbohydrates.
Research Limitation: This research focused on the production of herbal tea using negro, pepper, “prekese”, cloves and lemongrass.
Practical Implication: Healthcare systems benefit from validated safety standards for herbal products, reducing the burden of foodborne illnesses and contamination-related health issues.
Social Implication: The research contributes to food security by ensuring the safety and reliability of traditional herbal beverages while maintaining their cultural significance.
Originality/Value: This research contributes to food safety science by bridging traditional herbal knowledge with modern microbiological assessment methods, potentially influencing industry standards and regulatory frameworks.
External beam radiation therapy proves to be radical treatment for very high risk localized prostate cancer in active elderly patient
Authors: Yakovlev P. H. , Udatova T. V. , Rosha L. H. 
Published: December 2024

We present the case report of radical treatment of localized very high risk prostate cancer (рТ2сN0M0 Gleason score 5+5=10, GG5/5, initial total PSA=5 ng/ml) in active elderly patient by IMRT radiotherapy on linear accelerator Novalis Tx with definitive treatment dose 66 Gy without concomitant hormonal therapy. Efficiency of radiotherapy was demonstrated by PSA nadir <0.003 ng/ml, complete pathological response and absence of vital malignant tissue on histological study. The pathology study of the eradiated prostate gland was performed two years after radiotherapy on the specimen obtained after radical cystprostatectomy due to recurrent high-grade muscle-invasive bladder cancer. This way we could confirm that IMRP radiotherapy with dose of 66 Gy is a radical treatment of very high risk localized prostate cancer.
Application of Neuromuscular Electrical Stimulation Therapy in Stroke Rehabilitation
Authors: Ge Ling 
Published: December 2024

Stroke has a high incidence and disability rate, posing a heavy burden on patients, families, and society. Neuromuscular electrical stimulation (NMES) is a safe and effective rehabilitation treatment method that is increasingly being used in stroke rehabilitation therapy. This article reviews its current application status in treating various aspects such as limb swelling and spasms after stroke, explores its mechanism of action, clinical efficacy, and limitations, and provides a reference for clinical application.
Bioactivity of a drug based on nonspecific immunoglobulin and colloidal selenium particles for correction of the immune system of farm animals
Authors: Denisova Natalia Igorevna , Staroverov Sergey Aleksandrovich , Kozlov Sergey Vasilievich , Kozlov Evgeny Sergeevich , Shelkovaya Anastasia Andreevna 
Published: December 2024

The results of the scientific research of the production of acetone powder from a lyophilized culture of E. coli TG-1 with subsequent isolation of the antigen are presented in the article. The results of chromatographic purification of the obtained antigens and SDS-PAGE electrophoresis are also shown. The conjugation of the E. antigen coli TG-1 with a preparation based on nonspecific immunoglobulins and colloidal selenium particles and its physicochemical assessment have been reviewed. The results of immunization of animals with the E. antigen coli TG-1, conjugated with a drug based on nonspecific immunoglobulin and colloidal selenium particles, the titer of antibodies, interleukins and the proliferative activity of lymphocytes and the activity of peritoneal macrophages determined after slaughter are also presented.
Main parameters of adaptability of introduced early age grape varieties
Authors: Polukhina Elena Vladimirovna 
Published: December 2024

This article presents the results of studying main parameters of adaptability of introduced seedless grape varieties. The experience was laid down in the spring of 2020 according to the method of M.A. Lazarevsky on the territory of the vineyard of the Federal State Budgetary Scientific Institution “Precaspian Agrarian Federal Scientific Center of the Russian Academy of Sciences”. The landing pattern is 4.0 ? 2.0 m. The object of research was 16 seedless grape varieties of various breeding. The zoned Luchisty variety was a control. The conducted studies showed that the degree of maturation of shoots over three years of study was maximum in 2022, when the sum of active air temperatures above 10 °C during the growing season was 3679.3 ° C – from 90,6 % in the Neptune variety to 99.9 % in the Stoletie variety. The maximum leaf plate was in 2022 in the varieties Jupiter and Veles (99.8 cm2), Lucia (98.7 cm2), Neptune (89.9 cm2), Stoletie (86.7 cm2). Varieties Veles, Lucia, Stoletie were characterized by the highest values of leaf area per hectare – up to 1187.5 m2/ha. The maximum leaf surface index (leaf area per 1 m2 of soil surface) had Lucia and Veles varieties – 0,08 and 0.09 m2/m2, respectively. The standard variety Luchisty also had a fairly high level of leaf surface – 0.06 m2/m2.
The influence of biological product and nitrogen fertilizers on the dynamics of nitrate nitrogen content
Authors: Gaponov Sergey Nikolaevich , Sokolov Nikolai Mikhailovich , Saifullina Larisa Borisovna , Strelttsov Sergrey Borisovich , Korableva Irina Nikolaevna 
Published: December 2024

The research revealed conditions for activity of the biological product “Biocomposite-correct” and its effect on dynamics of accumulation of nitrate nitrogen in comparison with application of nitrogen fertilizers for various methods of basic tillage. The experiment was carried out in 2020 – 2022 on fields of the Federal Center of Agriculture Research of the South-East Region, soil - southern chernozem. Soil temperature at depth of 20 cm after application of the biological product in September 2021 (21.5...13.2 ?С) stimulated its activity. It explains significant differences in content of nitrate nitrogen in early spring in fallow fields in 2021 in variants with biological product compared to control for all methods of basic tillage (on average 23.19 and 5.4 mg/kg). Significance of difference in factors A - method of basic tillage (LSD0.5 - 0.403) and B - application of a biological product (LSD0.5 - 0.570) was revealed. When the soil was warmed to 13.7...14.4?С under winter wheat crops in May 2022, a predominant accumulation of nitrate nitrogen was noted when using the biological product in anti-erosion (18.95 mg/kg) and shallow ploughing methods (13.92; 16.82 mg /kg). In the control and fertilized variants, the indicator ranged from 1.86 to 6.79 mg/kg, except the control with anti-erosion methods (18.29 mg/kg of soil). Significant differences were noted for both factors (LSD0.5 – 0.033; 0.030). Significant differences in the grain yield of winter wheat were revealed for both factors. The best results were after application of the biological product and N30 during anti-erosion treatment (4.2; 4.7 t/ha).
Intelligent system for determining the strength of fiber cement soil
Authors: Chudinov Sergey Aleksandrovich , Karabutova Irina Andreevna 
Published: December 2024

The article discusses the methodology for developing an intelligent system based on an adaptive neuro-fuzzy network, which allows, with an average absolute error MAPE = 0.632 %, to calculate the compressive strength of fiber cement soil, taking into account the content of the additive Portland cement from 4 to 8% and basalt fiber from 0 up to 4% with fiber lengths from 5 to 45 mm. A decrease in the strength of fiber cement soil was revealed when it contained 4% Portland cement and basalt fiber with an average fiber length of up to 10 mm, due to a violation of the homogeneity and insufficient strength of the cement soil matrix to retain the fibers. To achieve maximum strength of fiber cement soil, the optimal content of basalt fiber additive has been established from 2.0 to 2.5 % with an average fiber length of 25 mm.
Application of herbicide and agrochemicals as factors for increasing the yield of sunflower hybrids on chestnut soil in the Trans-Volga region
Authors: Solodovnikov Anatoly Petrovich , Barbashin Vyacheslav Valerievich , Lekarev Andrey Vladimirovich , Fisunov Nikolay Vladimirovich , Abushaev Ildar Tagirovich 
Published: December 2024

In arid conditions of the Saratov Trans-Volga region on chestnut soil, the responsiveness of sunflower to the application of bioactivated fertilizers, microfertilizers, and herbicides was determined, and the most effective cultivation technologies were identified. These technologies will increase the yield of sunflower hybrids. Cultivation of hybrids Nusid H4XE; Nusid H4H302E; Nusid TALON increases the yield of oilseeds in relation to the hybrid Nusid H4219 by 11.0; 8.2 and 2.7%, respectively. Foliar feeding increases the yield by 15.3%. The application of the herbicide Canon (0.8 l/ha) increases the yield of sunflower oil seeds by 21.4 %. The combined use of herbicide and foliar feeding increased the yield of oil seeds by 34.7%. The maximum value of the profitability level in the cultivation technology of the sunflower hybrid Nusid H4XE was after application of the herbicide Canon (0.8 l/ha) in combination with foliar feeding with the complex bioactivated fertilizer Bionex-Kemi (2.5 kg/ha) and the microfertilizer MEGAMIX-Bor (0.4 l/ha), amounting to 74.7%.
The use of biological preparations in the technology of seed hemp cultivation
Authors: Bakulova Irina Vladimirovna , Pluzhnikova Irina Ivanovna , Kriushin Nikolay Viktorovich 
Published: December 2024

Innovative techniques in the technology of cultivating a new variety of hemp Lyudmila are considered. On average, over the years of research, protective measures to prepare seeds and the site for sowing had a positive effect on the yield and quality of hemp products. Seed yield on average for the options varied from 0.99 to 1.26 t/ha; in the options with Sternifag, WP treatment, the indicator was 1.17 t/ha, which is 0.03 t/ha higher than the option without treatment. With treatment options, a significant increase in seed yield was noted - from 0.09 to 0.25 t/ha. The greatest effect was obtained when treating with the biological preparation Baksis, L (an increase of 0.20 t/ha on average). The oil content of hemp seeds varied on average from 29.05 to 32.32%. In the seed protection options, oil content indicators increased from 30.19 to 32.24%, in the control – 30.09%. The highest protein content (29.35%) was obtained in the variants with treatment of the area before sowing with Sternifag, WP, the protein content increased by 0.99–2.08% depending on the treatment option. The content of total fiber in hemp stems ranged from 28.5 to 33.9% (4.0–5.6 t/ha), long fiber - from 15.7 to 22.6% (2.5–3.8 t/ha). The maximum values of total fiber were obtained with the treatment option Celest Top, SC (32.5 %, or 4.8 t/ha) and Baktofit, WP (32.25%, or 4.8 t/ha), long fiber - with the option with Baksis, L (18.55%, or 3.5 t/ha).
La vacunación en México, desde las expediciones del Dr. Francisco Javier de Balmis hasta el COVID-19 (SARS-Cov-2)
Authors: Hernández-Solis Alejandro , Andrea Hernández-de la Torriente  , Eliasib Mojica-Jaimes  , Fryda Jareth Serna-Valle  , Merari Velazquez-Gachuz  
Published: December 2024

Vaccines are one of the most important discoveries of humanity, being an effective intervention to protect the population against infectious diseases. When the Covid-19 vaccination campaign, the feat of Doctor Francisco Javier de Balmis y Berenguer in the “Royal Philanthropic Vaccine Expedition” is remembered due to the importance that vaccination has had over the years and mentioning that The National Vaccination Campaign against COVID-19 in Mexico began at the “Dr. Eduardo Liceaga” General Hospital of Mexico.
Keywords: Dr. Balmis; COVID-19; Vaccination campaign.
Consenso de tratamiento de la dermatitis atópica en atención primaria: resolviendo mitos y leyendas a partir de la evidencia
Authors: Sánchez Jorge , Arenas Claudia , Garcia Elizabeth , Ocampo Jaime , Gaitán-Rozo Julián David , Hamann Otto , Chapman Edgardo , Ramirez Ruth , Espinosa Tatiana , Velasquez Margarita , Tamayo Liliana , Torres-Pradilla Maurico , Jorge Leonardo Sánchez  , Guerrero-Román Mauricio , Ensina Luis-Felipe , Larco José Ignacio , Cherrez-Ojeda Ivan 
Published: December 2024

Atopic dermatitis (AD) is a disease that significantly impacts the quality of life of patients. Although there are multiple evidence-based guidelines, they are usually aimed at providing recommendations to AD specialists rather than primary care physicians (PCPs). The aim of this study was to construct a consensus document for PCPs, with the aim of presenting evidence-based recommendations that allow general practitioners, family physicians, pediatricians, internists and emergency physicians to provide appropriate care to AD patients, facilitating their diagnosis, management, and avoiding delays that can deteriorate patients’ f quality of life. As a central source of information, we used the recommendations of different international AD guidelines. Delegates from distinct medical societies identify barriers to care and possible solutions for the application of recommendations in primary care. Subsequently, a second evaluation for physicians from different Latin American countries was carried out. The main doubts and barriers that PCPs face in applying the recommendations proposed by the guidelines were identified across different areas, diagnostic criteria, non-pharmacological therapies, pharmacological therapies, management in special conditions and guidelines for referral to a specialist. Consensus solutions were proposed for each identified issue. In conclusion, this consensus contains recommendations regarding the management and treatment of AD in children and adults, which clarify doubts and provide tools to primary care physicians to offer effective treatment for patients and their families.
Keywords: Allergy; Primary care physicians; Atopy; Atopic dermatitis; Consensus; Latin America; Treatment; Evidence-based guidelines.
Application of Ground Penetrating Radar (GPR) Method for Evaluation of Sediment Structure in Paleotsunami Geopark Development Area, Aceh Besar, Indonesia
Authors: Putri Salsa Nazia , Ismail Nazli , Umar Muksin 
Published: December 2024

Ek Leuntie Cave is a karst cave in Meunasah Lhok, Lhoong District, Aceh Besar Regency. This cave is very rare. It has 12 tsunami layers dating back 7500 years. These layers need to be preserved as a paleotsunami geopark in Aceh. However, there are many challenges to developing public facilities in karst areas, such as sinkholes and landslides. Therefore, this study aims to investigate the potential hazards in the area by using the Ground Penetrating Radar (GPR) method at 700 MHz and 250 MHz frequencies. The GPR method is used because of its ability to image shallow subsurface structures with high resolution. The GPR method was used on 7 survey lines around Ek Leuntie Cave. The resulting radargrams are then processed using GPRPy software to clarify the reflection signal. GPR interpretation at 700 MHz and 250 MHz frequencies produces the same radargram at a very shallow depth, but the boundaries between layers are clearer at 700 MHz. Core data from multiple samples supports GPR interpretation. Based on the core data, the compact layer is located in the sandy soil layer, while the less compact layer is located in the old main road before the tsunami layer and in the bedrock. The less compact layer has potential hazards such as subsidence. The area is located in the west to south of the cave. Based on the GPR radargrams obtained, the investigation area is dominated by clay fill, sandy soil, clayey sand and bedrock. The results of the study are expected to be used as a reference for mitigation in the development of the Ek Leuntie Cave Geopark.
THE DYNAMICS OF THE EXCHANGE RATE: IMPACT OF STOCK PRICE MOVEMENTS OF UNDERPRICING ISSUERS
Authors: Yandes Jufri , Dwiyani Hadiwidjaja Rini , Pujiwati Ami , Fadillah Syarif 
Published: December 2024

This study analyzes the impact of exchange rates on the fluctuation of issuer share prices during underpricing in initial public offerings from 2022 to 2023. The primary focus is on situations where the initial public offering share price is traded lower than the closing price on the first trading day, known as underpricing. The study aims to provide new insights into how exchange rate dynamics influence underpricing levels and contribute to both practice and science. Based on data from 83 companies that went public during this period, the research methodology includes statistical description, classical assumption tests, and linear regression analysis. The results indicate a significant relationship between exchange rates and underpricing. These findings offer a deeper knowledge of the factors influencing underpricing, particularly in the context of exchange rate fluctuations. The practical implications include aiding investors, issuers, and regulators in making informed decisions.

Keywords : Exchange Rate, Initial Public Offering, Underpricing
Efeitos do Uso de Chupeta no Sucesso e Duração da Amamentação
Authors: Nunes Sousa João , Peixoto Raquel , Inês Ferreira Maria 
Published: December 2024

A chupeta é parte integrante dos lares de todo o mundo, aquando da existência de um recém-nascido. O seu uso tornou-se um hábito culturalmente enraizado, seguido pela maioria dos pais/tutores, mas foi surgindo receio de que a utilização deste objeto tenha influência negativa no sucesso da amamentação.Neste artigo de revisão, são apresentados os resultados mais recentes da literatura sobre a influência da chupeta na amamentação, abordando a importância da amamentação e as principais vantagens e desvantagens do uso de chupeta.Estudos observacionais apontam uma possível correlação entre o uso de chupeta e o insucesso da amamentação, mas essa associação não se confirmou em estudos de maior robustez como em ensaios clínicos randomizados.Face à evidência científica apresentada, os autores consideram que a chupeta deve ser oferecida, se essa for a vontade dos pais, tomando uma decisão partilhada e informada.
Radiological Evaluation of Length Discrepancy and Angular Deformity of Injured Growth Plate in Kit Rabbit Model
Authors: H Abd-Alkhaleq Sura , K Hussein Aseel 
Published: December 2024

Growth plate injury is one of the most significant sequelae that affect the animal and man life in adulthood. This condition considered as one of the real problem encountered by many orthopedics which can result in the formation of a bony bridge leading ultimately to limb length discrepancy and angular deformity of the long bones in kid animals. The objective of this study was to evaluate the deformities of the tibial length and angle radiographically after experimentally inducing growth plate injury. Five local breed kit rabbits included in this study, had body weight and age ranges of 500 to 1100 g and 6 to12 weeks, respectively. The animals were exposed to approximately 5×5×1 mm injury in the proximal tibial growth plate (type-III to IV classification. A radiological follow up at 1st, 2nd, 3rd and 4th week post inducing injury was made for possible evaluation of growth plate injury and calculate the length discrepancy of tibial and angular deformity by the end of the study. The radiological results revealed that bony bridge formation was clearly seen by 3rd and 4th weeks post induction. Furthermore, there were significant differences (P<0.05) in the length discrepancy of tibia started by 2nd week (P= 0.0175) and its angular deformity by 3rd week (P=0.0111) of the affected tibia limb and contralateral limb of the same animal up to the end of the study. In conclusion, the current study indicated that the formation of a bony bridge is a radiological sign of the damaged growth plate that ultimately leads to length discrepancy and angular deformity‎‎‎.
Storage Capacity of Different Stem Parts and its Role for Grain Productivity of Short-Term Drought-Exposed Winter Wheat Genotypes Contrasting in Drought Tolerance
Authors: Morgun V. V. , Stasik O. O. , Kiriziy D. A. , Tarasiuk M. V. 
Published: December 2024

Abstract: Remobilization of the water-soluble carbohydrates (WSC) deposited in the stem is important for winter wheat grain productivity, especially under water deficit during the reproductive period. Our aim was to study the accumulation and remobilization of reserve WSC in different segments of the stem and their relationship with grain yield parameters in winter wheat genotypes exposed to 8-day drought at the early stages of grain formation. The experiments were carried out on winter bread wheat (Triticum aestivum L.) plants grown in pots. Cultivars ‘Podolianka’ (drought-tolerant), ‘Podilska Nyva’ (high-yielding, less tolerant), ‘Natalka’ (less tolerant, high protein content in grain), and breeding line ‘UK 065’ (high-yielding, drought-sensitive) were studied. The specific content of WSC in dry matter and the total amount (product of specific content and dry weight) were determined in stem parts of the main shoot (counted from the top): peduncle, second, third, combined fourth and fifth (lower) internodes and combined leaf sheaths.
It was found that drought slightly reduced the maximum total amount of WSC deposited in the stem and significantly accelerated their remobilization. The studied genotypes of winter wheat differed significantly in the WSC accumulation in the stem: by 1.3 times under optimal conditions and by 1.5 times under drought, but the efficiency of WSC remobilization was similar and high (84–96%) in all of them, regardless of growing conditions. Cv. ‘Podolianka’ showed the highest storage capacity of the stem both under optimal watering and under drought. The contribution of deposited WSC to grain weight was 32 and 28.3% in cv. ‘Podolianka’, 21.3 and 24.6% in cv. ‘Podilska Niva’, 27.4 and 24.3% in cv. ‘Natalka’, and 18.2 and 22.4% in line 'UK065' under optimal and drought conditions, respectively.
The highest specific content and total amount of WSC were recorded in the second and third internodes. The portions of these internodes in the total amount of stem-deposited WSC were the largest in all studied genotypes. The content and total amount of reserve carbohydrates in the second and third internodes were correlated most closely with grain productivity, which gives reason to consider them the most representative parameters for assessing the storage capacity of the whole stem and to recommend them as a physiological marker of winter wheat genotypes’ performance.