bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydroxychloroquine Use and Cardiovascular Events Among Patients With Systemic Lupus Erythematosus and Rheumatoid Arthritis
Authors: Jorge April , Lu Na , Choi Hyon , Esdaile John M. , Lacaille Diane , Avina‐Zubieta J. Antonio 
Published: December 2021

ObjectiveWe evaluated the potential temporal association between hydroxychloroquine (HCQ) use and cardiovascular (CV) events among patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA).MethodsWe conducted a nested case–control study within inception cohorts of SLE and RA patients using administrative health databases including the entire population of British Columbia, Canada. We identified cases with incident CV events, including myocardial infarction (MI), stroke, or venous thromboembolism (VTE). We matched each case with up to 3 controls on age, sex, and rheumatic disease. HCQ exposure was categorized by the time between the last HCQ prescription date covered and the index date as current use, recent use, remote use, or never used. We used conditional logistic regression to assess the association between HCQ exposure and CV events, using remote use as the reference group.ResultsWe identified 10,268 cases and 29,969 controls. Adjusted conditional odd ratios (cORs) and 95% confidence intervals (95% CIs) for current HCQ use relative to remote use were 0.86 (0.77–0.97) for combined CV events, 0.88 (0.74–1.05) for MI, 0.87 (0.74–1.03) for stroke, and 0.74 (0.59–0.94) for VTE. Recent HCQ users and nonusers had similar odds of combined CV events as remote users (cORs 0.93, 95% CI 0.77–1.13 and 0.96, 95% CI 0.88–1.04, respectively).ConclusionIn this nested case–control study of patients with SLE and RA, we found a reduced risk of overall CV events associated with current HCQ use, including reductions in VTE and trends toward reductions in MI and stroke. These findings suggest a possible cardiovascular preventative benefit of HCQ use.
Health Literacy and Appropriateness of Self‐Care and Pain Management in Osteoarthritis: An Understanding of the Patient's Perspective
Authors: Hunter David J. , McLachlan Andrew J. , Carroll Peter R. , Wakefield Tom A. N. , Stosic Rodney 
Published: December 2021

ObjectiveManagement guidelines encourage self‐care in patients with symptomatic osteoarthritis (OA). We undertook this study to investigate the relationship between health literacy (HL) and appropriateness of selection of self‐care strategies in people with self‐reported symptoms of OA.MethodsWe conducted an online national observational, demographically representative, cross‐sectional survey of adults (ages 45–74 years). The eligibility criterion of “self‐reported OA symptoms” was screened for using guideline‐endorsed clinical criteria. Participants completed a custom‐built questionnaire that included validated scales for HL, pain intensity, sleep quality, and OA function/disability. Management strategies were grouped into self‐care activities, analgesics, and complementary medicines, and analyses of appropriateness were based on predefined, evidence‐based quality indicators.ResultsOf 6,800 participants, 628 met the inclusion criteria and completed the survey. HL was categorized as follows: low (100 of 628, 15.9%), moderate (317 of 628, 50.5%), and excellent (211 of 628, 33.6%). In the past 7 days, mean pain intensity (0–10 scale) was 3.11 (95% confidence interval [95% CI] 3.06–3.16), and 71.7% of participants (450 of 628) had not achieved adequate pain relief. In the past month, 54.1% (340 of 628) reported disrupted sleep. Participants managed their pain with multiple self‐care activities (mean 1.44; 95% CI 1.32–1.57), analgesics (mean 1.74; 95% CI 1.60–1.88), and complementary medicines (mean 1.01; 95% CI 0.90–1.12). There was a statistically significant (P < 0.001) interaction between HL and appropriateness of current management strategies (HL low, guideline‐recommended management strategies less likely). Higher HL did not always translate into making appropriate pain management choices.ConclusionAppropriate selection and use of evidence‐based management options is critical for patients with OA to obtain the full benefits from their treatment. Knowledge about suitable choices for OA self‐care is suboptimal, and future education should be tailored to different levels of HL.
Multimodal Enzyme‐Carrying Suprastructures for Rapid and Sensitive Biocatalytic Cascade Reactions
Authors: Jo Seong‐Min , Kim Jihye , Lee Ji Eun , Wurm Frederik R. , Landfester Katharina , Wooh Sanghyuk 
Published: December 2021

AbstractColloidal assemblies of mesoporous suprastructures provide effective catalysis in an advantageous volume‐confined environment. However, typical fabrication methods of colloidal suprastructures are carried out under toxic or harmful conditions for unstable biomolecules, such as, biocatalytic enzymes. For this reason, biocatalytic enzymes have rarely been used with suprastructures, even though biocatalytic cascade reactions in confined environments are more efficient than in open conditions. Here, multimodal enzyme‐ and photocatalyst‐carrying superstructures with efficient cascade reactions for colorimetric glucose detection are demonstrated. The suprastructures consisting of various functional nanoparticles, including enzyme‐carrying nanoparticles, are fabricated by surface‐templated evaporation driven suprastructure synthesis on polydimethylsiloxane‐grafted surfaces at ambient conditions. For the fabrication of suprastructures, no additional chemicals and reactions are required, which allows maintaining the enzyme activities. The multimodal enzymes (glucose oxidase and peroxidase)‐carrying suprastructures exhibit rapid and highly sensitive glucose detection via two enzyme cascade reactions in confined geometry. Moreover, the combination of enzymatic and photocatalytic cascade reactions of glucose oxidase to titanium dioxide nanoparticles is successfully realized for the same assay. These results show promising abilities of multiple colloidal mixtures carrying suprastructures for effective enzymatic reactions and open a new door for advanced biological reactions and enzyme‐related works.
Deciphering the Role of Defects in the Ambipolar Electrical Transport in Nanocrystalline Sb2Se3 Thin Films
Authors: González Juan Carlos , Limborço Henrique , Ribeiro‐Andrade Rodrigo , Silva Bruno Cordeiro , Krambrock Klaus 
Published: December 2021

AbstractThe role of two defects in the ambipolar character of nanocrystalline selenium poor Sb2Se3 is studied. At low temperature, the electrical transport in Sb2Se3 thin films with nm‐sized crystallites and grains is dominated by the ionization of a shallow acceptor, while at high temperature a deep donor is the leading one. The ionization energy of the deep donor agrees with theoretical reports for selenium vacancies. However, the value of the ionization energy of the shallow acceptor is in contradiction with theoretical reports pointing out to an unreported shallow defect. These findings have been confirmed by two independent experimental techniques, Electron Paramagnetic Resonance, and electrical transport as a function of temperature. The mobility of the free carriers has been found not to be limited by grain potential barriers (GPB), in contrast with polycrystalline thin films. Both findings, new shallow acceptor and zero height GPB, constitute advantages for the design of nanostructured Sb2Se3‐based solar cells and other optoelectronic devices. These results not only provide useful information for the growth of nanocrystalline Sb2Se3 thin films with ambipolar transport properties, but also about the complexity of defect physics in low‐symmetry and Q1D semiconductors.
The impact of hiatal hernia on survival outcomes in patients with gastroesophageal junction adenocarcinoma
Authors: Tanaka Yuya , Kinoshita Takahiro , Akimoto Eigo , Sato Reo , Yura Masahiro , Harada Junichiro , Yoshida Mitsumasa , Tomi Yoshiaki 
Published: December 2021

AbstractAimA hiatal hernia (HH) complicates the diagnosis and surgical treatment of gastroesophageal junction (GEJ) cancer. This study aimed to investigate the effect of HH on the survival outcomes of GEJ cancer patients.MethodsThis single‐center study reviewed clinical data of 78 patients with GEJ adenocarcinoma who underwent R0 resection from 2008 to 2017. The patients were divided into two groups according to whether they presented with or without HH: the HH (+) group (n = 46) and the HH (−) group (n = 32).ResultsPatients in the HH (+) group were older than those in the HH (−) group (69.0 vs 67.5 years, P = .018). Regarding surgical outcomes, intra‐abdominal infectious complications was more common in the HH (+) group than in the HH (−) group (23.9% vs 9.4%, respectively; P = .089), particularly abscess formation (17.4% vs 3.1%, respectively; P = .036). Neither overall survival (OS) nor relapse‐free survival (RFS) differed between the two groups. However, survival rates were significantly worse in a subset of patients with T3‐4 disease (OS: log‐rank, P = .036) (RFS: log‐rank, P = .040) in the HH (+) group. In a multivariate analysis for OS in this cohort, HH was an independent prognostic factor (hazard ratio 3.60; 95% confidence interval 1.06‐11.9, P = .032).ConclusionHiatal hernia may adversely affect surgical and survival outcomes in patients with GEJ cancer. Thus, surgical strategy must be carefully considered in these patients.
Dinuclear PtII Complexes with Strong Blue Phosphorescence for Operationally Stable Organic Light‐Emitting Diodes with EQE up to 23 % at 1000 cd m−2
Authors: Lo Kar‐Wai , Tong Glenna So Ming , Cheng Gang , Low Kam‐Hung , Che Chi‐Ming 
Published: December 2021

AbstractHere we describe the synthesis and characterization of a new class of dinuclear PtII complexes with blue phosphorescence. Bulky N‐heterocyclic carbene and tethered bridging ligands were employed to suppress photo‐induced structural changes and to improve thermal stability of the complexes. These complexes show mixed 3IL/3MLCT blue emission (≈460 nm) with emission quantum yields of up to 0.95, emission lifetimes of as low as 1.3 μs and radiative decay rate constants of up to 7.3×105 s−1 in 4 wt % doped PMMA films; the latter is attributed to a 1MLCT excited state having high metal character (resulting in a large SOC) and a large transition dipole moment, based on DFT calculations. Phosphor‐sensitized blue hyper‐OLEDs with Commission Internationale de L'Eclairage (CIE) coordinates of (0.13, 0.12) showed a maximum EQE of 23.4 % with a full‐width‐at‐half‐maximum of 18 nm and a LT50 >250 h at an L0 of 1000 cd m−2.
Organometallic (η6‐p‐cymene)ruthenium(II) complexes with thiazolyl‐based organic twigs: En route towards targeted delivery via human serum albumin of the potential anticancer agents
Authors: Khan Rais Ahmad , BinSharfan Ibtisam I. , Alterary Seham S. , Alsaeedi Huda , Qais Faizan Abul , AlFawaz Amal , Hadi Arman D. , Alsalme Ali 
Published: December 2021

AbstractIn this article, we have designed the new ruthenium(II) p‐cymene complexes [Ru(η6‐p‐cymene) HLThz,Me Cl] 1 and [Ru(η6‐p‐cymene) HLThz Cl] 2 with two auxiliary ligand (E)‐1‐(((5‐methylthiazol‐2‐yl)imino)methyl)naphthalen‐2‐ol (HLThz,Me) and (E)‐1‐((thiazol‐2‐ylimino)methyl)naphthalen‐2‐ol (HLThz), keeping in mind the vehicle HSA. The spectroscopic techniques, namely, Fourier transform infrared spectroscopy (FT‐IR), proton nuclear magnetic resonance (1H NMR), 13C NMR, and elemental analysis were employed for the characterization. The single X‐ray crystallography ascertains the molecular structure of the representative complex [Ru(η6‐p‐cymene) HLThz,Me Cl] 1. Furthermore, the density functional theory (DFT) calculation was performed for geometry optimization and frontier molecular orbitals analysis. Moreover, in silico studies were carried out to understand the binding site and the mode of interaction of the complexes with human serum albumin (HSA). The in vitro interaction of the HSA measured extrinsic fluorescence at various temperatures, namely, 298, 303, and 308 K, whereas the intrinsic fluorescence extent was evaluated in the presence of 8‐anilinonaphthalene‐1‐sulfonic acid (ANS). The cytotoxicity of these compounds was evaluated against HeLa, MCF7, HepG2, A549, and A2780 cancer cells and compared with HEK293 non‐tumorigenic cells (cisplatin and RAPTA‐C as control). The complex 1 showed significantly good cytotoxicity in the range of IC50 value <10 μM against A2780 (ovarian cancer) and HepG2 (liver) cells and lower toxicity up to >100 μM. These findings give illustrative insight into the binding propensity of complexes 1 and 2 with HSA (model protein). Further, they can be explored for en route drug delivery to a specific site as anticancer metallodrugs.
ESIPT Active Assemblies for ‘On‐On’ Detection, Cell Imaging and Hampering Cellular Activity of 2,6‐Dichloro‐4‐nitroaniline
Authors: Devi Minakshi , Sharma Pooja , Kumar Ajay , Kaur Satwinderjeet , Kumar Manoj , Bhalla Vandana 
Published: December 2021

AbstractESIPT active PBI‐keto/enol assemblies have been developed which show ‘on‐on’ optical response towards 2,6‐dichloro‐4‐nitroaniline (DCN) due to a combined ESIPT‐AIEE phenomenon with a detection limit of 1.65 nM. The potential of PBI‐keto/enol assemblies to detect DCN has also been explored in grape juice/grape residue and soil for six consecutive days. Further, the biological applications of PBI‐keto/enol assemblies to detect DCN in blood serum, in MG‐63 cell lines and their ability to restrict the DCN‐induced cell death have been demonstrated.
Planet interactions at a young age
Authors: Micela Giuseppina , Cecchi‐Pestellini Cesare , Colombo Salvatore , Locci Daniele , Petralia Antonino 
Published: December 2021

AbstractThe study of young planetary systems is of great importance for understanding their formation and evolution. Therefore, today, a great effort is placed on the observation and modeling of such systems. Of course, planets do not evolve in isolation, but their behavior depends on the host star and the environment in which they are embedded. In particular, we know that at young ages, solar‐type stars are much more active than sun‐age stars with all the phenomena that this involves, including strong emission at high energies, from ultraviolet (UV) to X‐rays, stellar winds, frequent flares, and coronal mass ejection emission. Such an energetic environment has an important influence on planetary atmospheres. It is now widely accepted that high‐energy radiation can drive planetary evaporation, especially of hot low‐density planets, and may also have a strong impact on the thermal structure and chemical compositions of the atmospheres. X‐rays and extreme ultraviolet (EUV) photons have different roles, since the former produce cascades of energetic secondary electrons, and penetrate deep in the atmospheres, reaching in some cases the planetary surface. Their effects are strongly dependent on metallicity since they are absorbed mainly from high z elements. On the contrary, the effects of EUV are concentrated on the upper layers of the atmospheres and are fairly independent of the presence of metals since they are efficiently absorbed by hydrogen and helium. In this paper, we will review some of the recent outcomes of star‐planet interactions studies during the young stellar ages.
Neubau der Patton Brücke über die Sauer
Authors: Gesella Heiko 
Published: December 2021

AbstractIm Zuge der Umsetzung des Infrastrukturprojekts „Umsteigebahnhof Ettelbruck“ – etwa 30 km nördlich der Landeshauptstadt Luxemburg gelegen – wurde die neue Patton Brücke elegant über die Sauer und die Eisenbahnlinie Luxemburg‐Troisvierges geschlagen. Die Stahlverbundbrücke mit einer Länge von 170 m führt die Nationalstraße N 7 mit drei Fahrstreifen und breitem Fahrradweg als Zubringer zum Umsteigebahnhof. Das Bauwerk fügt sich harmonisch in seine Umgebung ein, die von der Lage zwischen einem Naturschutzgebiet Natura 2000 im Norden und der Industriezone „um Dreieck“ im Süden sehr konträr geprägt wird. Das wartungsarme und dauerhafte semiintegrale Bauwerk aus wetterfestem Baustahl weist infolge der doppelt im Raum gekrümmten Straßenachse eine komplexe Geometrie auf, die von einer starken Grundrisskrümmung bestimmt wird. Der Entwurf ordnet sich vollständig dem integralen Tragwerksgedanken unter. Damit kommt der Ausbildung der konstruktiven Details als Schnittstellen zwischen den Tragwerksteilen besondere Bedeutung zu. In diesem Zusammenhang werden insbesondere die monolithischen Anschlüsse der Y‐förmigen Pfeiler zum Überbau und deren Fortsetzung im Baugrund als Pfahlbock beleuchtet, die im Zusammenspiel mit der gesamthaften Steifigkeitsabstimmung das gewünschte Verhalten des Tragwerks gewährleisten. Im Folgenden wird von der diesbezüglichen Planung und von der darauf abgestellten Bauausführung berichtet.
A clinical trial to compare a 3D‐printed bolus with a conventional bolus with the aim of reducing cardiopulmonary exposure in postmastectomy patients with volumetric modulated arc therapy
Authors: Zhang Yun , Huang Yuling , Ding Shenggou , Liang Jinghui , Kuang Jie , Mao Qingfeng , Ying Weiliang , Shu Yuxian , Li Jingao , Jiang Chunling 
Published: December 2021

AbstractBackgroundWe compared the dosimetry, application, and acute toxicity of a 3D‐printed and a conventional bolus for postmastectomy radiotherapy (PMRT) with volumetric modulated arc therapy (VMAT).Materials and Methods Eligible patients (n = 75) with PMRT breast cancer were randomly selected to receive VMAT with a conventional bolus or a 3D‐printed bolus. The primary endpoint was a 10% decrease in the mean heart dose to left‐sided breast cancer patients. The secondary endpoint was a 5% decrease in the mean ipsilateral lung dose to all patients. A comparative analysis was carried out of the dosimetry, normal tissue complication probability (NTCP), acute skin toxicity, and radiation pneumonitis.ResultsCompared to a conventional bolus, the mean heart dose in left‐sided breast cancer was reduced by an average of 0.8 Gy (5.5 ± 1.3 Gy vs. 4.7 ± 0.8 Gy, p = 0.035) and the mean dose to the ipsilateral lung was also reduced by an average of 0.8 Gy (12.4 ± 1.0 Gy vs. 11.6 ± 0.8 Gy, p < 0.001). The values for V50Gy of the PTV of the chest wall for the 3D‐printed and conventional boluses were 95.4 ± 0.6% and 94.8 ± 0.8% (p = 0.026) and the values for the CI of the entire PTV were 0.83 ± 0.02 and 0.80 ± 0.03 (p < 0.001), respectively. The NTCP for the 3D‐printed bolus was also reduced to an average of 0.14% (0.32 ± 0.19% vs. 0.18 ± 0.11%, p = 0.017) for the heart and 0.45% (3.70 ± 0.67% vs. 3.25 ± 0.18%, p < 0.001) for the ipsilateral lung. Grade 2 and Grade 1 radiation pneumonitis were 0.0% versus 7.5% and 14.3% versus 20.0%, respectively (p = 0.184).ConclusionsThe 3D‐printed bolus may reduce cardiopulmonary exposure in postmastectomy patients with volumetric modulated arc therapy.
Systolic and diastolic blood pressure, prostate cancer risk, treatment, and survival. The PROCA‐life study
Authors: Stikbakke Einar , Schirmer Henrik , Knutsen Tore , Støyten Martin , Wilsgaard Tom , Giovannucci Edward L. , McTiernan Anne , Eggen Anne E. , Haugnes Hege S. , Richardsen Elin , Thune Inger 
Published: December 2021

AbstractBackgroundInflammation has been linked to prostate cancer and hypertension, but it remains equivocal whether elevated blood pressure (BP) influence prostate cancer risk and survival.MethodUsing Cox regression models, we examined the association between prediagnostic BP and prostate cancer risk among 12,271 men participating in the Prostate Cancer throughout life (PROCA‐life) study. Systolic and diastolic BP were measured. A total of 811 men developed prostate cancer, and followed for additional 7.1 years, and we studied the association between prediagnostic BP and overall mortality among patients with prostate cancer.ResultsMen (>45 years) with a systolic BP >150 mmHg had a 35% increased risk of prostate cancer compared with men with a normal systolic BP (<130 mmHg) (HR 1.35, 95% CI 1.08–1.69). Among patients with prostate cancer, men with systolic BP >150 mmHg had a 49% increased overall mortality compared with men with a normal systolic BP (HR 1.49, 1.06–2.01). Among patients with prostate cancer treated with curative intent, those with a high diastolic BP (>90 mmHg) had a threefold increase in overall mortality risk (HR 3.01, 95% CI 1.40–6.46) compared with patients with a normal diastolic BP (<80 mmHg).ConclusionOur results support that systolic and diastolic BP are important factors when balancing disease management in patients with prostate cancer.
Reliability and validity of an auditing tool for person‐centred psychotherapy and counselling for young people: The PCEPS‐YP
Authors: Ryan Gemma , Bhatti Kiran , Duncan Charlie , McGinnis Susan , Elliott Robert , Cooper Mick 
Published: December 2021

AbstractThe present study aimed to test the reliability and validity of the Person Centred and Experiential Psychotherapy Scale–Young Person version (PCEPS‐YP). This is a newly developed and adapted 9‐item scale which aims to measure counsellor competences in, and adherence to, person‐centred practice, when working with adolescents. Counselling practice was assessed for 19 counsellors by randomly selecting 20‐min audio segments from 142 recorded counselling sessions. Audio material was independently rated by eight raters using the PCEPS‐YP to produce an average adherence rating per counsellor. Scale reliability was assessed via interrater reliability and internal consistency testing. Convergent validity was tested using ratings from the observer‐rated Barrett‐Leonard Relationship Inventory (BLRI Obs 40), and the scale was subjected to exploratory factor analysis. Results showed a high degree of internal consistency within raters (α = 0.95), marginally acceptable reliability across grouped raters (α = 0.58) and weaker reliability between pairs of raters (α = 0.50). Exploratory factor analysis revealed one strong factor for the scale with no subscales. Small‐to‐moderate correlations existed between the PCEPS‐YP and the BLRI subscales and mean total score (rs = .12 to .40). Our findings suggest that the PCEPS‐YP has potential as an effective, reliable and valid tool for assessing competence and adherence in person‐centred practice with young people, both for research and for clinical purposes. However, training procedures need to be established that can enhance interrater reliability, and more evidence of convergent validity is needed.