bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of the Templating Heteroatom on Both Structural and Magnetic Properties of POM‐Based SIM Lanthanoid Complexes
Authors: Cañón‐Mancisidor Walter , Paredes‐Castillo Gabriela , Hermosilla‐Ibáñez Patricio , Venegas‐Yazigi Diego , Cador Olivier , Le Guennic Boris , Pointillart Fabrice 
Published: September 2021

AbstractThe plasticity of the coordination chemistry of Lanthanoid ions (LnIII) has allow the design of novel coordination compounds with slow relaxation of the magnetization since the first Single Ion Magnet (SIMs) was reported by Ishikawa, who used the phthalocyaninate ligand to make a “sandwich type” complex. The coordination chemistry has allowed the possibility to design different types of molecular complexes with SIMs behaviour based on organic ligands. There is also SIMs based on inorganic ligands, using different types of lacunary polyoxometalates (LPOM) like, [XW11O39]n−. The combination of both types of ligands can produce hybrid inorganic‐organic LnIII complexes with SIM behaviour. This is an attractive approach since these hybrid materials could benefit from the combination of the ease of functionalization of the organic ligands with the robustness of the inorganic moieties. There are reports that a hybrid mononuclear DyIII complex could improve the relaxation dynamics when it is compared to the inorganic analogues. Thus, in this review we present a study and comparison on the improvement that inorganic and organic ligands can cause to the geometry of the metal centres of fully inorganic and hybrid (mononuclear and dinuclear) lanthanoid complexes (for DyIII, ErIII and YbIII). Moreover, we will discuss which of these changes can modify the magnetic properties of the Lanthanoid Complexes.
A Mechanistic Study on the Reaction of Non‐Heme Diiron(III)‐Peroxido Complexes with Benzoyl Chloride
Authors: Lerch Markus , Achazi Andreas J. , Mollenhauer Doreen , Becker Jonathan , Schindler Siegfried 
Published: September 2021

AbstractDinuclear iron peroxido complexes are important intermediates for selective oxidation reactions. A detailed kinetic study of the reaction of benzoyl chloride (BzCl) with a dinuclear iron non‐heme cis end‐on peroxido complex with the ligand EtHPTB (N,N,N′,N′‐tetrakis[(N‐ethyl‐2‐benzimidazolyl)methyl]‐2‐hydroxy‐1,3‐diamino‐propane) had been performed. The starting complex, the iron peroxido complex, can be obtained either by reaction of the iron(II) complex with O2 or instead, applying the corresponding iron(III) complex together with hydrogen peroxide. Using low temperature stopped‐flow measurements allowed to obtain activation parameters and in combination with a Hammet plot it was possible to postulate a mechanism for the formation of a perbenzoate complex prior to its decomposition. Furthermore, the direct reaction of the dinuclear iron(III) EtHPTB complex with peracetic acid was analyzed. Additionally, in comparison a mononuclear non‐heme iron complex with the ligand bztpen (N‐benzyl‐N,N′,N′‐tris(2‐pyridylmethyl)ethane‐1,2‐diamine) was investigated as well.
Stereoselective Aldol and Conjugate Addition Reactions Mediated by Proline‐Based Catalysts and Its Analogues: A Concise Review
Authors: Valapil Durgesh Gurukkala , Kadagathur Manasa , Shankaraiah Nagula 
Published: September 2021

AbstractThe application of amino acids and small peptides as asymmetric organocatalysts in the aldol and conjugate addition reactions is a significant breakthrough in the past decade. The desired stereoselectivity in these reactions can be attained through tunable elements of diversity present in the amino acids/peptides. On this note, the current review highlights the organocatalytic aldol and conjugate addition by proline or its analogous in the form of amide/peptide derivatives. The wide‐ranging works of literature are classified based on the use of single amino acid or peptides as a catalyst. The designing of the aforementioned amide/amino acid/peptide catalyst, including their recent applications, is also detailed. Moreover, the analogous catalysts are also discussed, embedding other hetero‐organic functionalities that mimic the catalytic activity of proline in aldol/conjugate additions.
Diethylaminosulfur Trifluoride (DAST) Mediated Transformations Leading to Valuable Building Blocks and Bioactive Compounds
Authors: Kaźmierczak Marcin , Bilska‐Markowska Monika 
Published: September 2021

AbstractNucleophilic fluorination is one of the fundamental reactions in organic chemistry, as well as a convenient tool for the synthesis of fluorinated building blocks with a potential biological activity. In this minireview, diethylaminosulfur trifluoride (DAST) mediated reactions leading to valuable building blocks and bioactive compounds will be discussed. We focused on results that have been published since 2010. Transformation of β‐amino alcohols, heterocyclic frameworks synthesis, as well as rearrangement reactions have been described in detail.
Differentiation of Different Sorts of Sugars by the CAPoNeF Method
Authors: Nigmatullin R. R. , Sidelnikov A. V. , Maksyutova E. I. , Budnikov H. C. , Govorov E. V. 
Published: September 2021

AbstractThe proposed method as CAPoNeF (Comparative Analysis of Positive and Negative Fluctuations) allows to “read” any trendless sequence quantitatively irrespective of the imposed model and treatment errors that inevitably accompany random sequence. This method will have a wide possibility because of its generality and simplicity in possible applications. In particular, the proposed strategy makes it possible to detect weak signals in the time electrochemical series caused by the presence of random micro‐impurities in the studied solutions as objects of analysis. On the example of the current‐voltage time series of sugar syrups of various manufacturers, the possibility of identifying numerical parameters is shown. Hidden in the noise, analytical signals can be used to express the similarity or difference between sugars from different manufacturers.
Label‐free Electrochemical Aptasensor for the Determination of Serotonin
Authors: Li Rong , Li Xiaoxia , Su Liu , Qi Hetong , Yue Xuanfeng , Qi Honglan 
Published: September 2021

AbstractA label‐free electrochemical aptasensor was fabricated for the determination of serotonin (5‐HT) by the employment of specific binding between 5‐HT and aptamer and directly electrochemical measurement of 5‐HT oxidation. The comparison between two aptasensors and two strategies was studied. An electrochemical aptasensor fabricated using 57‐mer aptamer was facilely used to determine 5‐HT in the range from 1 μM to 100 μM with detection limit of 0.3 μM via one step recognition and detection. This work demonstrates that electrochemical method combing aptamer recognition and 5‐HT oxidation provides an alternative and promising method for the determination of 5‐HT with good selectivity and simplicity.
Performance evaluation, Optimization and exergy analysis of a high temperature co‐electrolysis power to gas process using Aspen Plus®‐a model based study
Authors: Khesa Neo , Mulopo Jean 
Published: September 2021

AbstractIn this paper, a high temperature coelectrolysis power to gas (LTE PtG) setup was developed that was fed a stereotypical feed in CO2 one could acquire from carbon capture and sequestration (CCS) retrofit. The electrolyzer was fed an equimolar 10 kmol/s feed in water and CO2 and the electrolyzer product was composed of 38.80 mole% CO2, 30.96 mole% CO, and 30.24 mole% H2 for a syngas conversion of 43.8%. The product from the methanation unit was only composed of 21.38 mole% CH4, with the rest (76.53 mole%) being predominantly CO2. The methanation unit was composed of only one Sabatier reactor operating at 313°C, which had 90% of its product recycled back to the front end of the unit. The electrolyzer was found to have a LHV efficiency of 31.49%, and the entire HTCE PtG process was found to have an efficiency of 74.31% with methane storage and 76.49% without methane storage. A novel adaptation was developed on previous work on the exergy analysis for flow‐sheet simulators which can be used for cyclic and noncyclic processes. The procedure was determined to be accurate, with irreversibilities determined across all the major subunits found to equal the irreversibility around the processes a whole. The electrolyzer was found to be responsible for the majority of the irreversibility within the setup, and this was attributed to the fact that water electrolysis is a very energy intensive process. The exergy efficiency of the electrolyzer was found to be 87.07% and that of the entire LTE PtG processes was found to be 84% with methane storage, and 87% without methane storage. In the end, it was determined that HTCE is unsuitable for the production of methane via retrofit with a methanation unit, and that it would be better suited for the production of liquid hydrocarbon fuels with much higher molecular carbon to hydrogen ratios.
Food neophobia and intervention of university students in China
Authors: Tian Hua , Chen Jie 
Published: September 2021

AbstractBackgroundFood neophobia was defined as the unwillingness or avoidance to eat new foods. There are many studies on food neophobia in children, but few in university students. This study was to examine the level of food neophobia of Chinese university students. The aim is to find a way to help them relieve food neophobia.MethodsA total of 2,366 university students (16–22 years old) from Xinyang normal university were recruited to conduct a questionnaire survey on food neophobia scale (FNS) of Chinese version, which contained 10 questions. Significant difference analysis and principal component analysis were conducted.ResultsFor Chinese university students, willingness to try new food, trust in new food, eating disorder, and food pickiness were the characteristic indexes to evaluate the food neophobia. Gender had no significant effect, but long‐term nutrition courses had a great impact on food neophobia of university students.ConclusionsThe level of food neophobia of Chinese university students is relatively high. To formulate and implement a continuous diet and nutrition education plan is good and necessary to relieve the food neophobia.Implications for PracticeThese data complement the limited literature on food neophobia of university students, which will help to develop intervention plans to reduce eating disorders and support the need for further research to reveal the potential mechanism.
N‐3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development
Authors: Leyrolle Quentin , Decoeur Fanny , Dejean Cyril , Brière Galadriel , Leon Stephane , Bakoyiannis Ioannis , Baroux Emilie , Sterley Tony‐Lee , Bosch‐Bouju Clémentine , Morel Lydie , Amadieu Camille , Lecours Cynthia , St‐Pierre Marie‐Kim , Bordeleau Maude , Roumes Helene , De Smedt‐Peyrusse Véronique , Séré Alexandran , Schwendimann Leslie , Grégoire Stephane , Bretillon Lionel , Acar Niyazi , Joffre Corinne , Ferreira Guillaume , Uricaru Raluca , Thebault Patricia , Gressens Pierre , Tremblay Marie‐Eve , Layé Sophie , Nadjar Agnes 
Published: September 2021

AbstractWesternization of dietary habits has led to a progressive reduction in dietary intake of n‐3 polyunsaturated fatty acids (n‐3 PUFAs). Low maternal intake of n‐3 PUFAs has been linked to neurodevelopmental disorders, conditions in which myelination processes are abnormal, leading to defects in brain functional connectivity. Only little is known about the role of n‐3 PUFAs in oligodendrocyte physiology and white matter development. Here, we show that lifelong n‐3 PUFA deficiency disrupts oligodendrocytes maturation and myelination processes during the postnatal period in mice. This has long‐term deleterious consequences on white matter organization and hippocampus‐prefrontal functional connectivity in adults, associated with cognitive and emotional disorders. Promoting developmental myelination with clemastine, a first‐generation histamine antagonist and enhancer of oligodendrocyte precursor cell differentiation, rescues memory deficits in n‐3 PUFA deficient animals. Our findings identify a novel mechanism through which n‐3 PUFA deficiency alters brain functions by disrupting oligodendrocyte maturation and brain myelination during the neurodevelopmental period.
Predicting brain age during typical and atypical development based on structural and functional neuroimaging
Authors: Wang Qi , Hu Ke , Wang Meng , Zhao Yuxin , Liu Yong , Fan Lingzhong , Liu Bing 
Published: September 2021

AbstractExploring typical and atypical brain developmental trajectories is very important for understanding the normal pace of brain development and the mechanisms by which mental disorders deviate from normal development. A precise and sex‐specific brain age prediction model is desirable for investigating the systematic deviation and individual heterogeneity of disorders associated with atypical brain development, such as autism spectrum disorders. In this study, we used partial least squares regression and the stacking algorithm to establish a sex‐specific brain age prediction model based on T1‐weighted structural magnetic resonance imaging and resting‐state functional magnetic resonance imaging. The model showed good generalization and high robustness on four independent datasets with different ethnic information and age ranges. A predictor weights analysis showed the differences and similarities in changes in structure and function during brain development. At the group level, the brain age gap estimation for autistic patients was significantly smaller than that for healthy controls in both the ABIDE dataset and the healthy brain network dataset, which suggested that autistic patients as a whole exhibited the characteristics of delayed development. However, within the ABIDE dataset, the premature development group had significantly higher Autism Diagnostic Observation Schedule (ADOS) scores than those of the delayed development group, implying that individuals with premature development had greater severity. Using these findings, we built an accurate typical brain development trajectory and developed a method of atypical trajectory analysis that considers sex differences and individual heterogeneity. This strategy may provide valuable clues for understanding the relationship between brain development and mental disorders.
Differential diagnoses of solitary and multiple pigmented lesions of the oral mucosa: Evaluation of 905 specimens submitted to histopathological examination
Authors: Tavares Thalita Soares , Da Costa Adriana Aparecida Silva , Aguiar Maria Cássia Ferreira , Loyola Adriano Mota , Barcelos Natália Santos , Abreu Mauro Henrique Nogueira Guimarães , Mesquita Ricardo Alves , Tarquínio Sandra Beatriz Chaves , De Moraes Êmile , Vasconcelos Ana Carolina Uchôa , Costa Nádia Lago , Mendonça Elismauro Francisco , Cardoso Sérgio Vitorino , Nonaka Cassiano Franscisco Weege , Andrade Allany de Oliveira , Johann Aline Cristina Batista Rodrigues , Michels Arieli Carini , Libório‐Kimura Tatiana Nayara , Neto Gerson Oliveira Paiva , Caldeira Patrícia Carlos 
Published: September 2021

AbstractBackgroundThe aim was to analyze the frequency, clinical and demographic features of solitary and multiple/diffuse oral pigmented lesions submitted to histopathological examination, and to summarize the features that guide the clinical differential diagnosis.MethodsClinical and demographic data were retrieved from biopsy records and descriptive statistics were performed.ResultsNine hundred and five (0.51%) oral pigmented lesions were retrieved among 177 356 specimens, being 95.9% solitary and 4.1% multiple/diffuse lesions. Regardless the overlapping clinical presentation, age, site, association with amalgam restoration, and a nodular appearance may help in the clinical differential diagnosis of solitary oral pigmentations. Patient's habits, site, and systemic signs and symptoms are helpful in the clinical differential diagnosis of multiple/diffuse lesions.ConclusionsOral pigmented lesions are a rare diagnosis in oral pathology and solitary lesions are more commonly submitted to biopsy. Some key features help in the differential diagnosis, though biopsy can be warranted in doubtful cases.
The RNA binding protein human antigen R is a gatekeeper of liver homeostasis
Authors: Subramanian Pallavi , Gargani Sofia , Palladini Alessandra , Chatzimike Margarita , Grzybek Michal , Peitzsch Mirko , Papanastasiou Anastasios D. , Pyrina Iryna , Ntafis Vasileios , Gercken Bettina , Lesche Mathias , Petzold Andreas , Sinha Anupam , Nati Marina , Thangapandi Veera Raghavan , Kourtzelis Ioannis , Andreadou Margarita , Witt Anke , Dahl Andreas , Burkhardt Ralph , Haase Robert , Domingues António Miguel de Jesus , Henry Ian , Zamboni Nicola , Mirtschink Peter , Chung Kyoung‐Jin , Hampe Jochen , Coskun Ünal , Kontoyiannis Dimitris L. , Chavakis Triantafyllos 
Published: September 2021

Abstract

Background and Aims
NAFLD is initiated by steatosis and can progress through fibrosis and cirrhosis to HCC. The RNA binding protein human antigen R (HuR) controls RNAs at the posttranscriptional level; hepatocyte HuR has been implicated in the regulation of diet‐induced hepatic steatosis. The present study aimed to understand the role of hepatocyte HuR in NAFLD development and progression to fibrosis and HCC.

Approach and Results
Hepatocyte‐specific, HuR‐deficient mice and control HuR‐sufficient mice were fed either a normal diet or an NAFLD‐inducing diet. Hepatic lipid accumulation, inflammation, fibrosis, and HCC development were studied by histology, flow cytometry, quantitative PCR, and RNA sequencing. The liver lipidome was characterized by lipidomics analysis, and the HuR–RNA interactions in the liver were mapped by RNA immunoprecipitation sequencing. Hepatocyte‐specific, HuR‐deficient mice displayed spontaneous hepatic steatosis and fibrosis predisposition compared to control HuR‐sufficient mice. On an NAFLD‐inducing diet, hepatocyte‐specific HuR deficiency resulted in exacerbated inflammation, fibrosis, and HCC‐like tumor development. A multi‐omic approach, including lipidomics, transcriptomics, and RNA immunoprecipitation sequencing revealed that HuR orchestrates a protective network of hepatic‐metabolic and lipid homeostasis–maintaining pathways. Consistently, HuR‐deficient livers accumulated, already at steady state, a triglyceride signature resembling that of NAFLD livers. Moreover, up‐regulation of secreted phosphoprotein 1 expression mediated, at least partially, fibrosis development in hepatocyte‐specific HuR deficiency on an NAFLD‐inducing diet, as shown by experiments using antibody blockade of osteopontin.

Conclusions
HuR is a gatekeeper of liver homeostasis, preventing NAFLD‐related fibrosis and HCC, suggesting that the HuR‐dependent network could be exploited therapeutically.
Regioselective Short Synthesis of Epiisoborneol Neopentyl Ether as Chiral Auxiliary: An Absolute Configuration Reset
Authors: Piątek Anna , Chapuis Christian 
Published: September 2021

AbstractThe regio‐selective four step synthesis of (1S,2R,3S,4R)‐4,7,7‐trimethyl‐3‐(neopentyloxy)bicyclo[2.2.1]heptan‐2‐ol, as recognized efficient chiral auxiliary, is presented. The strategy based on opening of the key acetal 15 (=(2S,3aR,4S,7R,7aS)‐2‐tert‐butyl‐4,8,8‐trimethylhexahydro‐2H‐4,7‐methano‐1,3‐benzodioxole) thus circumvents the poor reactivity of the neopentyl electrophile under alkylation conditions. Following the same strategy, but using the unreported acetal 22 (=(2R,3aS,4S,7R,7aR)‐2‐tert‐butyl‐4,8,8‐trimethylhexahydro‐2H‐4,7‐methano‐1,3‐benzodioxole), the corresponding unreported bis‐endo alcohol 23 (=(1R,2R,3S,4S)‐3‐(2,2‐dimethylpropoxy)‐4,7,7‐trimethylbicyclo[2.2.1]heptan‐2‐ol) could be isolated only in poor yield. An alternative regioselective synthesis, including an ultimate endo‐reduction remains to be found. Several erroneous chiroptical properties from the literature are corrected.
The influence of dietary patterns on outcomes in a Bayesian choice task
Authors: Dickinson David L , Garbuio Caleb 
Published: September 2021

AbstractBackground and AimsPrevious research has investigated the impact of diet on cognition, but the focus has often been on general cognition. This paper reports on a preregistered cross‐sectional study aimed at testing for specific executive function differences across individuals who self‐reported one of four distinct dietary patterns: No Diet, No Sugar, Vegetarian, or Mediterranean Diet pattern. Our hypotheses were aimed at testing whether adherence to a specialty diet improved decision making relative to those who reported following No Diet.MethodsWe administered an incentivized Bayesian choice task to all participants. The task involved multiple components of information—existing information (base rate odds) as well as new information (sample draw evidence)—to allow a test of how these information components were used in making probability assessments, and how this may differ by self‐reported dietary pattern. Sample size, hypotheses, and analysis plans were all determined ex ante and registered on the Open Science Framework. Multi‐variate linear and non‐linear estimation methods were used to analyze the data.ResultsOur data failed to support our pre‐registered hypotheses. In fact, we found some evidence that self‐reported adherence to a specialty No Sugar Diet was associated with a reduced decision accuracy and was connected to an increased imbalance in how the participant weighted the two available sources of information when making choices.ConclusionOur results suggest that decision making is nuanced among dietary groups, but that short‐term incentivized decisions in an ecologically valid field setting are likely not improved solely by following promoted dietary patterns such as the Mediterranean or Vegetarian diets.
The onset of Darcy–Brinkman–Rayleigh–Benard convection in a composite system with thermal diffusion
Authors: Sumithra Ramakrishna , Komala Basavarajappa , Manjunatha Narayanappa 
Published: September 2021

AbstractThe effect of thermal diffusion on the onset of double‐diffusive convection is analyzed by considering a composite system of the fluid‐saturated porous layer. The porous layer of the composite system is modeled employing the Darcy–Brinkman–Rayleigh–Benard model. The boundaries of the composite system are assumed to be rigid‐rigid under normal gravitational force. The governing equations satisfying the Darcy–Brinkman–Rayleigh–Benard model are solved using the regular perturbation method. A mathematical expression is derived for the critical thermal Rayleigh number by solving the coupled equation. The impact of various physical parameters on the onset of convection is graphically represented under the influence of the Soret effect and the stability of the system is analyzed.