bluuebunny/crossref_metadata_2025_split huggingface dataset:
Betriebliches Gesundheitsmanagement – Analyse akademischer Ausbildungskonzepte in Deutschland
Authors: Wedel S. , Nöfer E. , Schütz A. 
Published: May 2021

Zusammenfassung
Hintergrund
Die akademischen Ausbildungsangebote zu den Themen betriebliches Gesundheitsmanagement (BGM) und betriebliche Gesundheitsförderung (BGF) sind vielfältig. Bislang gibt es keine genaue Übersicht darüber, welche Studiengänge in Deutschland als späteres Berufsfeld explizit BGM oder BGF nennen und welche Lerninhalte sie vermitteln.

Ziel der Arbeit
Ziel dieser Arbeit war die Analyse der akademischen Ausbildungskonzepte zum BGM. Studiengänge, die explizit auf das spätere Betätigungsfeld BGM/BGF abzielen, wurden recherchiert und ihre Lerninhalte analysiert.

Material und Methoden
Mithilfe der Suchbegriffe „Gesundheit“ und „Health“ wurden Studiengänge identifiziert, die BGM oder BGF als berufliche Perspektive nennen. 60 entsprechende Studiengänge wurden mithilfe einer qualitativen Inhaltsanalyse hinsichtlich der Lerninhalte ausgewertet.

Ergebnisse
Die Gesundheitswissenschaften bilden mit 22 % der Lerninhalte das am häufigsten vertretene Wissenschaftsgebiet. Daneben sind Lerninhalte aus den Bereichen Wirtschaftswissenschaften (14 %), Medizin (7 %), Psychologie (7 %) und Sportwissenschaften (6 %) häufig vertreten. Weitere wichtige Elemente bilden Lerninhalte zur Förderung der Forschungskompetenz sowie Praktika. Insgesamt zeigt sich große Varianz hinsichtlich der Lerninhalte.

Diskussion
Studiengänge unterschiedlicher Ausrichtungen (gesundheitswissenschaftlich, psychologisch und sportwissenschaftlich ausgerichtet) unterscheiden sich hinsichtlich ihrer Lerninhalte erheblich. Dennoch beanspruchen alle, die Absolvent*innen auf eine Tätigkeit im Bereich BGM/BGF vorzubereiten. Obwohl Arbeitsschutz und betriebliches Eingliederungsmanagement (BEM) laut Literatur wesentliche Säulen des BGM sind, spiegeln sich diese Themen kaum in den Lerninhalten der Studiengänge wieder.
Development trend of urban design in “digital age”: Pan-dimensionality and individual-ubiquity
Authors: Wang Jianguo 
Published: May 2021

AbstractThe wave of “digital age” featuring digital information is coming. Digital technology is profoundly changing the societal development direction and evolution paths. It also has significant bearing on production modes, social interactions and lifestyles. With regard to urban design, a system of knowledge about the creation and adaptation of material space forms that integrate humanities, art, technology and materials, digital technology has provided it with a brand-new and revolutionary scientific impetus for its evolution. The result of this evolution is “digital urban design paradigm based on human-computer interaction”, i.e., the urban development is moving toward “pan-dimensionality” and “individual ubiquity”. The future of urban design will construct a new approach to urban research and engineering, which is more complex, capable of accommodating and compatible with multiple goals of “instrumental rationality” and “value rationality”. Such a new approach shall be led by the probabilistic theory of “gray scale thinking”, reflecting quaternary synergetic view of “scientific rationality, ecological rationality, cultural rationality and technical rationality” to realize the cognitive progress of “engineering for the benefit of mankind”.
CO2 emissions and energy technologies in Western Europe
Authors: Barrera-Santana J. , Marrero Gustavo A. , Puch Luis A. , Díaz Antonia 
Published: May 2021

AbstractIn this paper, we investigate the path to the green transition in Europe. In so doing, we implement an empirical model of dynamic panel data on a sample of sixteen Western European countries over the period 1980 to 2019. The model is consistent with various features of neoclassical growth theory incorporating energy use. Our focus is on the short-run determinants of carbon emissions within that set of countries. We provide evidence that the relationship between economic activity and CO2 emissions is strong in economies where economic booms depend on energy-intensive sectors. Also, the mitigating role of renewable energy technologies is key when energy intensity rebounds. These circumstances may constitute a challenge for the climate transition goals targeted in the EU’s Recovery Plan, whose main objective at this very moment is to mitigate the economic and social impact of the coronavirus pandemic.
Simulation of Images and Digital Terrain Models for the Mission BepiColombo
Authors: Borin Nicolò , Re Cristina , Simioni Emanuele , Debei Stefano , Cremonese Gabriele 
Published: May 2021

AbstractBepiColombo mission will provide Digital Terrain Models of the surface of Mercury by means of the stereo channel of the SIMBIO-SYS (Spectrometer and Imaging for MPO BepiColombo Integrated Observatory SYStem) imaging package onboard. The work here described presents a novel approach for the creation of higher resolution stereo products using the high-resolution channel of SIMBIO-SYS. Being the camera rigidly integrated with the spacecraft, this latter must be tilted to acquire stereo pairs necessary for the 3D reconstruction. A new method for image simulation and stereo reconstruction is presented in this work, where the input data are chosen as closely as possible to the real mission parameters. Different simulations are executed changing the illumination conditions and the stereo angles. The Digital Terrain Models obtained are evaluated and an analysis of the best acquisition conditions is performed, helping to improve the image acquisition strategy of BepiColombo mission. In addition, a strategy for the creation of a mosaic from different images acquired with the high-resolution channel of SIMBIO-SYS is explained, giving the possibility to obtain tridimensional products of extended targets.
Effects of Additional Rifle-Carriage Training on Physiological Markers and Roller-Skiing Performance in Well-Trained Biathletes
Authors: Jonsson Kårström Malin , McGawley Kerry , Laaksonen Marko S. 
Published: May 2021

Abstract
Purpose
The purpose was to investigate whether an increased amount of training while carrying the rifle affects skiing in well-trained biathletes at submaximal and maximal workloads during a pre-season period lasting a minimum of 12 weeks.

Methods
Seventeen well-trained biathletes (9 females, 8 males) were assigned to an intervention (IG, n = 10) or control (CG, n = 7) group. Before (T1) and after (T2) the training intervention all participants performed, using treadmill roller-skiing, a submaximal test without the rifle on one day and two submaximal workloads and a maximal time trial (TT) with the rifle on a subsequent day. Between T1 and T2 all participants performed a minimum of 12 weeks of normal training, the only difference between groups being that IG performed more of their training sessions carrying the rifle.

Results
IG performed more training compared to CG (15.4 ± 1.1 vs. 11.2 ± 2.6 h/week, P < 0.05), including a higher amount of training with the rifle (3.1 ± 0.6 vs. 1.1 ± 0.3 h/week, P < 0.001). Speed at 4 mmol/L of blood lactate increased significantly for CG from T1 to T2 (P = 0.028), while only tended to increase for IG (P = 0.058). Performance during the TT, VO2max and the aerobic metabolic rate increased significantly from T1 to T2, although the differences disappeared when including the speed at baseline as a covariate.

Conclusion
According to the present results, increasing training while carrying the rifle by 2 h/week does not appear to improve skiing performance in well-trained biathletes. In addition, physiological markers at submaximal and maximal intensities while carrying the rifle were not affected after the training intervention.
Monitoring the Performance of Alpine Skiers with Inertial Motion Units: Practical and Methodological Considerations
Authors: Supej Matej , Holmberg H-C 
Published: May 2021

AbstractAlthough reliable feedback is crucial to improving the performance of competitive alpine skiers, the coach's eye may not be sensitive enough to detect small, but highly significant “mistakes”. Monitoring of the performance of alpine ski racers by inertial motion units (IMU) has proven to be of value in this context and here we summarize practical and methodological aspects of this approach. Methodologically, the IMUs employed should combine high sampling frequencies with minimal signal drift. The sensors should be positioned to sense the movement of the bones in a given body segment while being protected as much as possible against impact with the ski gates. The data obtained, often synchronized with input from Global Satellite Navigation Systems (GNSS), are usually refined utilizing advanced biomechanical models and other computerized approaches. In practice, the combination of inertial sensors and GNSS allows accurate monitoring of skiing kinematics (technique) and the movement of the skier’s center-of-mass, also allowing analysis of both whole-body vibrations (WBV) and loss of mechanical energy. Presentation of the findings to coaches and athletes can be facilitated by synchronizing them with video recordings. Recent advances in IMU technology, including miniaturization, wireless communication, direct storage of data in the cloud, and processing with artificial intelligence may allow these sensors, in-combination with GNSS, to become real-time virtual alpine ski coaches, perhaps the next step in the development of this sport.
Beilinson–Drinfeld Schubert varieties and global Demazure modules
Authors: Dumanski Ilya , Feigin Evgeny , Finkelberg Michael 
Published: May 2021

AbstractWe compute the spaces of sections of powers of the determinant line bundle on the spherical Schubert subvarieties of the Beilinson–Drinfeld affine Grassmannians. The answer is given in terms of global Demazure modules over the current Lie algebra.
ONGILGAMESHAND HOMER: ISHTAR, APHRODITE AND THE MEANING OF A PARALLEL
Authors: Ballesteros Bernardo 
Published: May 2021

AbstractThis article reconsiders the similarities between Aphrodite's ascent to Olympus and Ishtar's ascent to heaven inIliadBook 5 and the Standard BabylonianGilgameshTablet VI respectively. The widely accepted hypothesis of an Iliadic reception of the Mesopotamian poem is questioned, and the consonance explained as part of a vast stream of tradition encompassing ancient Near Eastern and early Greek narrative poetry. Compositional and conceptual patterns common to the two scenes are first analyzed in a broader early Greek context, and then across further Sumerian, Akkadian, Ugaritic and Hurro-Hittite sources. The shared compositional techniques at work in Mesopotamia and the Eastern Mediterranean can be seen as a function of the largely performative nature of narrative poetry. This contributes to explaining literary transmission within the Near East and onto Greece.
Nutrition and physical activity interventions for the general population with and without cardiometabolic risk: a scoping review
Authors: Rozga Mary , Jones Kelly , Robinson Justin , Yahiro Amy 
Published: May 2021

AbstractObjective:The objective of this scoping review was to examine the research question: In the adults with or without cardiometabolic risk, what is the availability of literature examining interventions to improve or maintain nutrition and physical activity-related outcomes? Sub-topics included: (1) behaviour counseling or coaching from a dietitian/nutritionist or exercise practitioner, (2) mobile applications to improve nutrition and physical activity and (3) nutritional ergogenic aids.Design:The current study is a scoping review. A literature search of the Medline Complete, CINAHL Complete, Cochrane Database of Systematic Reviews and other databases was conducted to identify articles published in the English language from January 2005 until May 2020. Data were synthesised using bubble charts and heat maps.Setting:Out-patient, community and workplace.Participants:Adults with or without cardiometabolic risk factors living in economically developed countries.Results:Searches resulted in 19 474 unique articles and 170 articles were included in this scoping review, including one guideline, thirty systematic reviews (SR), 134 randomised controlled trials and five non-randomised trials. Mobile applications (n37) as well as ergogenic aids (n87) have been addressed in several recent studies, including SR. While primary research has examined the effect of individual-level nutrition and physical activity counseling or coaching from a dietitian/nutritionist and/or exercise practitioner (n48), interventions provided by these practitioners have not been recently synthesised in SR.Conclusion:SR of behaviour counseling or coaching provided by a dietitian/nutritionist and/or exercise practitioner are needed and can inform practice for practitioners working with individuals who are healthy or have cardiometabolic risk.
Space ectogenesis: securing survival of humans and Earth life with minimal risks – reply to Szocik
Authors: Edwards Matthew R. 
Published: May 2021

Abstract
Assuming that securing the long-term survival of humans and Earth life is a valid goal, we briefly compare the strategies of building standard space colonies, such as on Mars, and embryo space colonization (ESC). In ESC embryos of humans and other Earth species would be sent to exoplanets and raised there via ectogenesis and android assistants. We find that the potential for securing long-term survival is far greater for ESC than for standard colonies, while the bioethical and other risks are far fewer.
Beveling the Colorado Plateau: Early Mesozoic Rift‐Related Flexure Explains Erosion and Anomalous Deposition in the Southern Cordilleran Foreland Basin
Authors: Chapman James B. , DeCelles Peter G. 
Published: May 2021

AbstractDeposition of the Late Jurassic Morrison Formation in a back‐bulge depozone and formation of the overlying sub‐Cretaceous unconformity above a forebulge mark the birth of the foreland basin system in the central U.S. Cordillera. In the southern U.S. Cordillera, the Morrison Formation is either anomalously thick or absent and the sub‐Cretaceous unconformity cuts out progressively older stratigraphy toward the south on the Colorado Plateau. Based on results of 2D and 3D flexural modeling, we suggest that flexural uplift of the northern rift flank of the Bisbee segment of the Borderland Rift Belt can explain these observations. Structural restoration of the sub‐Cretaceous unconformity indicates a minimum of 1.5 km of uplift and flexural models with an effective elastic thickness of 55 ± 5 km can reproduce the geometry of the unconformity and rift flank. This implies that effective elastic thickness has decreased between the Jurassic and the present, consistent with hypotheses for uplift and modification of the Colorado Plateau lithosphere during the Late Mesozoic to Cenozoic. Modeling results also predict the presence of a rift‐related flexural trough in the Four Corners region of the Colorado Plateau, which may explain above‐average thickness of the Morrison Formation. Constructive interference between a flexural back‐bulge depozone and a flexural rift‐flank trough may help explain anomalously high Late Jurassic subsidence.
Seasonality in Saharan Dust Across the Atlantic Ocean: From Atmospheric Transport to Seafloor Deposition
Authors: van der Does Michèlle , Brummer Geert‐Jan A. , Korte Laura F. , Stuut Jan‐Berend W. 
Published: May 2021

AbstractSaharan dust is transported in great quantities from the North African continent every year, most of which is deposited across the North Atlantic Ocean. This dust impacts regional and global climate by affecting the atmospheric radiation balance and altering ocean carbon budgets. However, little research has been carried out on time series of Saharan dust collected in situ across the open Atlantic. Here, we present a unique three‐year time series of Saharan dust along a trans‐Atlantic transect, sampled by moored surface buoys and subsurface sediment traps. Results show a good correlation between the particle‐size distributions of atmospheric dust and the lithogenic particles settling to the deep ocean floor, confirming the aeolian origin of the lithogenic particles intercepted by the subsurface sediment traps, even in the distal western part of the Atlantic Ocean. Dust from both dry and wet deposition as collected by the sediment traps, shows increased deposition fluxes and coarser grain size in summer and/or autumn that coincides with increased precipitation at the sampling sites as derived from satellite data. In contrast, both buoys that sampled dust during transport at sea level show little seasonal variation in both concentration and particle size, as the large amounts of dust transported in summer and early autumn at high altitudes are far above their sampling range. This implies that wet deposition in summer and autumn defines the typical seasonal trends of both the dust deposition flux and its particle‐size distribution observed in the sediment traps.
Proteomics of extracellular vesicles in plasma reveals the characteristics and residual traces of COVID-19 patients without underlying diseases after 3 months of recovery
Authors: Mao Kaimin , Tan Qi , Ma Yanling , Wang Sufei , Zhong Hua , Liao Yuhan , Huang Qi , Xiao Wenjing , Xia Hui , Tan Xueyun , Luo Ping , Xu Juanjuan , Long Danling , Jin Yang 
Published: May 2021

AbstractMore and more patients suffered from Coronavirus disease 2019 (COVID-19) have got recovery gradually due to suitable intervention. Increasing data mainly studies the clinical characteristics of recovered COVID-19 patients, and their molecular changes especially proteome changes also play the same important role in understanding of biological characteristics of recovered COVID-19 patients as clinical characteristics do. In our study, we reported the whole lung-ground glass-CT value-average of mild/severe recovered patients 3 months after discharge without underlying diseases was significantly lower than that of healthy subjects. Then we isolated the extracellular vesicles (EVs) of plasma from 19 healthy subjects and 67 recovered COVID-19 patients. Mass Spectrometry was used to catalogue the proteins of these EVs compared to a defined group of controls. Identified 174 proteins were differentially expressed in the EVs of COVID-19 patients compared with healthy subjects, which involved in lipid metabolic process, response to cellular, and response to stress oxygen-containing compound. Besides, we identified several protein of plasma EVs in recovered patients associated with coagulation activity, inflammatory reaction, immune response, and low organ function. In addition, proteins correlating with clinical index such as alkaline phosphatase (ALP) and alanine aminotransferase (ALT) were also detected. Moreover, we also identified many unique or characteristic associations found in the recovered COVID-19 patients, which especially involved the kidney, serum electrolyte levels, and inflammation functions. This finding suggests that monitoring the situation of recovered patients might be useful, especially the indexes of coagulation, inflammation, immunity, and organ function, which can prevent bleeding, reinfection and organ dysfunction.
CBX7 suppresses urinary bladder cancer progression via modulating AKR1B10–ERK signaling
Authors: Huang Zhengnan , Yan Yilin , Zhu Zhen , Liu Jiakuan , He Xiao , Dalangood Sumiya , Li Meiqian , Tan Mingyue , Cai Jinming , Tang Pengfei , Huang Ruimin , Shen Bing , Yan Jun 
Published: May 2021

AbstractThe chromobox (CBX) proteins mediate epigenetic gene silencing and have been implicated in the cancer development. By analyzing eight CBX family members in TCGA dataset, we found that chromobox 7 (CBX7) was the most strikingly downregulated CBX family member in urinary bladder cancer (UBC), as compared to normal tissues. Though dysregulation of CBX7 has been reported in multiple cancers, its specific role and clinical relevance in UBC remain unclear. Herein, we found that frequent downregulation of CBX7 in UBC specimens, which was due to its promoter hypermethylation, was correlated with poor prognosis. The ectopic expression of CBX7 suppressed UBC cell proliferation, migration, invasion, and cancer stemness, whereas CBX7 depletion promoted cancer cell aggressiveness. Importantly, CBX7 overexpression in UBC cells inhibited tumorigenicity, whereas CBX7 depletion promoted the tumor development, indicating its tumor-suppressive role in UBC. Using RNA-seq and chromosome immunoprecipitation (ChIP) assays, we identified aldo-keto reductase family 1 member 10 (AKR1B10) as a novel downstream target of CBX7, which was negatively modulated by CBX7 in a PRC1-dependent manner and involved in stimulating ERK signaling. Consistently, AKR1B10 overexpression induced cancer cell aggressiveness, whereas suppression of AKR1B10 by siRNA or its small molecular inhibitor, oleanolic acid, reversed the CBX7 deficiency-induced cellular effects. AKR1B10 overexpression was negatively associated with CBX7 downregulation and predicted poor clinical outcomes in UBC patients. Taken together, our results indicate that CBX7 functions as a tumor suppressor to downregulate AKR1B10 and further inactivates ERK signaling. This CBX7/AKR1B10/ERK signaling axis may provide a new therapeutic strategy against UBC.
Identification of putative causal loci in whole-genome sequencing data via knockoff statistics
Authors: He Zihuai , Liu Linxi , Wang Chen , Le Guen Yann , Lee Justin , Gogarten Stephanie , Lu Fred , Montgomery Stephen , Tang Hua , Silverman Edwin K. , Cho Michael H. , Greicius Michael , Ionita-Laza Iuliana 
Published: May 2021

AbstractThe analysis of whole-genome sequencing studies is challenging due to the large number of rare variants in noncoding regions and the lack of natural units for testing. We propose a statistical method to detect and localize rare and common risk variants in whole-genome sequencing studies based on a recently developed knockoff framework. It can (1) prioritize causal variants over associations due to linkage disequilibrium thereby improving interpretability; (2) help distinguish the signal due to rare variants from shadow effects of significant common variants nearby; (3) integrate multiple knockoffs for improved power, stability, and reproducibility; and (4) flexibly incorporate state-of-the-art and future association tests to achieve the benefits proposed here. In applications to whole-genome sequencing data from the Alzheimer’s Disease Sequencing Project (ADSP) and COPDGene samples from NHLBI Trans-Omics for Precision Medicine (TOPMed) Program we show that our method compared with conventional association tests can lead to substantially more discoveries.