bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hybrid odontogenic lesions: A systematic review of 203 cases reported in the literature
Authors: Pontes Flavia Sirotheau Correa , Mosqueda‐Taylor Adalberto , de Souza Lucas Lacerda , de Paula Lorena Paula , Batista Luana Araújo Lobo , Rodrigues‐Fernandes Carla Isabelly , Paiva e Costa Anderson Maurício , de Abreu Michelle Carvalho , Gomez Ricardo Santiago , de Oliveira Eduardo Morato , Fonseca Felipe Paiva , Rahimi Siavash , Brennan Peter A. , Pontes Hélder Antônio Rebelo 
Published: September 2021

AbstractBackgroundHybrid odontogenic lesions combine histopathological characteristics of two or more odontogenic cysts and/or tumours. The aim of this study was to evaluate the available data on hybrid odontogenic lesions (HOL) and to analyse their epidemiological/clinical features and biological behaviour.MethodsAn electronic search was done in January 2021 using multiple databases. Eligibility criteria encompassed publications with sufficient clinical and histological information to confirm the tumours’ diagnoses.ResultsA total of 147 articles were included in this study, comprising 203 cases. Calcifying odontogenic cyst associated with odontoma (COC/OD) (37/18.2%) was the most common HOL. Females were more affected with a mean age of 24.9 years. Lesions presented as asymptomatic swellings, with a mean evolution time of 8.2 months (0.3–96), and mean tumour size of 4.8 cm (0.3–7). Radiographic aspects frequently showed radiolucent (139/68.4%) and unilocular (52/25.6%) images with well‐defined limits (48/23.6%). The lesions mostly affected mandibular pre‐molars (69/34%) and mandibular molars (69/34%) regions. Enucleation (89/43.8%) and surgical excision (59/29%) were the most common treatment modalities. The mean follow‐up time was 33.8 months (0.5–216 months) and recurrences were observed in four cases (1.9%), all of which were central odontogenic fibroma associated with central giant cell granuloma (COF/CGCG).ConclusionCOC/OD is the most common HOL and recurrence is a rare event, being usually associated with the diagnosis of COF/CGCG.
Digital Workflow for Double Complete Arch Zirconia Prostheses Utilizing a Novel Scan Body
Authors: Marinis Aristotelis , Papaspyridakos Panos , Sicilia Elena , Bernardes Sergio Rocha , Touloumi Foteini , Chochlidakis Konstantinos , Weber Hans‐Peter 
Published: August 2021

AbstractThe purpose of this clinical report is to present a complete digital workflow for the fabrication of complete arch fixed zirconia implant restorations. An intraoral scanner was used to capture the implants’ position at the abutment level and also the patient's existing interim prostheses with the double digital scanning technique. A novel scan body and impression pin were utilized throughout the scanning process which allowed for the accurate and reproducible superimposition of the generated Standard Tesselation Language (STL) files. Prosthesis prototypes were digitally designed and fabricated, tried in, and verified intraorally. The definitive zirconia prostheses were then fabricated and delivered to the patient. This technique can be utilized in both arches overcoming the absence of stable intraoral landmarks for superimposition of STL files.
Aroma active compound perception in differently roasted and brewed coffees by gas chromatography–olfactometry
Authors: Laukaleja Ilze , Koppel Kadri 
Published: August 2021

AbstractCoffee has a complex volatile compound profile, which can be influenced by technical processes like roasting and brewing. The changes in the volatile compound profile can affect the perceived aromas. Headspace‐solid‐phase microextraction technique (HS–SPME) coupled with gas chromatography–mass spectrometry (GC–MS) and gas chromatography–olfactometry (GC–O) were used to achieve the objectives of this study: (1) to develop gas chromatography–olfactometry vocabulary for coffee brews, and (2) to analyze aroma active compound perception in differently roasted and brewed coffee. The GC–O vocabulary included 23 different aromas and 30 aroma‐active compounds. The main aroma attributes in all samples were sweet, musty, leather, skunky, burnt, and nutty. Aroma active compounds in medium roasted coffee presented floral, sweet notes, while light coffee had more nutty and roasted aroma attributes. The data from GC–MS–O suggested that roasting degree and brewing technique can influence the aroma perception of aroma active compounds. Dark roasted coffees had the least varied aroma attributes but had a higher concentration of aroma contributing compounds like 2,2′‐methylenebis‐furan (musty) and 4‐ethyl‐2‐methoxyphenol (smokey). The results also revealed that overall volatile compound composition could change the aroma perception of some coffee brew volatiles.Practical ApplicationsThe development of olfactory vocabulary and aroma active compound perception analysis can be useful for further coffee aroma analysis, characterizing volatile compound aroma changes depending on roasting and brewing technique. For the coffee industry, the olfactory vocabulary could bring an additional understanding of aroma active compound perception in differently roasted and brewed coffees.
Sensory perception and food neophobia drive liking of functional plant‐based food enriched with winemaking by‐products
Authors: Pagliarini Ella , Spinelli Sara , Proserpio Cristina , Monteleone Erminio , Fia Giovanna , Laureati Monica , Gallina Toschi Tullia , Dinnella Caterina 
Published: August 2021

AbstractThe use of phenol compounds obtained from unripe grapes as antioxidant sustainable food ingredients is challenging due to their specific sensory attributes, such as sourness and astringency. The aim was to evaluate sensory attributes perception and consumers' liking for beetroot purees added with phenols from unripe grapes. According to hedonic responses, consumer clusters were identified and characterized for eating behavioral attitudes. Three hundred two subjects (56% women, 18–60 years old) evaluated sweet, sour, astringency, and overall flavor intensity of and liking for four beetroot puree samples added with increasing phenols concentrations (0–1.93 g/kg). Results showed that liking decreased with increasing phenols. Interestingly, samples with highest phenols concentration, characterized by sourness, and astringency, were preferred by a segment of consumers (39% of the group). This group was characterized by a low food neophobia and tended to have high emotional eating scores compared to consumers preferring samples without or with the lowest amount of extract. These results suggest that the development of functional phenol‐enriched products using winemaking by‐products is challenging due to their sensory properties that negatively influence consumers' acceptance. However, with appropriate segmentation strategies it is possible to identify specific consumer targets who could appreciate these new functional foods.Practical ApplicationsUnripe grapes can be used as a sustainable phenol source for the development of new highly antioxidant foods. Indeed, an addition till 1.9 g/kg, besides improving both the nutritional content of the food matrices, as well as promoting the reuse of winemaking by‐products, could be considered feasible from a sensory point of view. Specifically, new sustainable plant‐based food product, characterized by specific sensory attributes, could be target for specific groups of consumers to foster the transition to the consumption of food products developed using value‐added and sustainable ingredients.
Effects of Medicaid expansion on self‐reported use of dental services in socioeconomically vulnerable subgroups
Authors: Swankoski Kaylyn E. , Fishman Paul A. , Chi Donald L. , Wong Edwin S. 
Published: September 2021

AbstractObjectiveResearch suggests Medicaid expansion led to modest increases in the use of dental services among low‐income adults, especially in states with more generous Medicaid dental benefits. We expand upon this research by examining whether the effect of Medicaid expansion differed across important socioeconomic subgroups.MethodsUsing Behavioral Risk Factor Surveillance System data from 2012 to 2016, we employed a difference‐in‐differences framework to estimate the effect of Medicaid expansion on annual use of dental services overall and by whether states offered more‐than‐emergency Medicaid dental benefits. We used generalized linear mixed‐effects model trees to estimate effects across socioeconomic subgroups (e.g., age, education, race, income).ResultsThe effect of Medicaid expansion varied by state's generosity of Medicaid dental coverage and combinations of socioeconomic subgroups. Overall, there was no significant association between Medicaid expansion and probability of using dental services (−0.1 pp percentage points [pp], p = 0.914). Medicaid expansion was associated with a modest increase in the probability of using dental services in states with more‐than‐emergency Medicaid dental benefits (2.3 pp, p < 0.001) and with a modest decrease in states with no or emergency‐only benefits (−4.3 pp, p < 0.001). Among adults aged 21–35 without a high school diploma, Medicaid expansion was associated with an 8.1 pp (p = 0.003) increase in dental use probability, but there were no associated effects of Medicaid expansion for other subgroups.ConclusionsWhile Medicaid expansion alone is not sufficient to ensure adults receive recommended dental care, some vulnerable subgroups appear to have benefited. Efforts to mitigate barriers to dental care may be needed to increase uptake of dental services by low‐income adults.
Effects of ecotrofin™ on milk yield, milk quality and serum biochemistry in lactating goats
Authors: Musco Nadia , Morittu Valeria Maria , Mastellone Vincenzo , Spina Anna Antonella , Vassalotti Giuseppe , D’Aniello Biagio , Tudisco Raffaella , Infascelli Federico , Lombardi Pietro 
Published: September 2021

AbstractA nutritional supplement (Ecotrofin™, by Vetoquinol Italia S.r.l) recommended in ruminants feeding to strengthen the physiological condition and improve digestive performance was tested in 20 pluriparae grazing goats divided in two groups (control and treated) to assess its possible effects on milk yield and quality and to assess eventual adverse effects. Animals from both groups also received 400 g/day of corn meal, and the treated group was supplemented with 20 g/head/day of the nutritional supplement. At the doses suggested by the manufacturer, despite a transient increase after 30 days of supplementation, Ecotrofin™ did not show significant effects on milk yield and, although some changes were found in the fatty acids profile, no significant improvement of MUFA and PUFA, as well as of omega‐6:omega‐3 ratio and CLA content were seen. Therefore, in our experimental conditions the supplementation of diet with Ecotrofin™ did not appear useful to improve goat's performance. A significant effect on kidney health markers (27 vs. 22.5 for urea and 0.83 vs. 0.76 for creatinine, p < 0.05) suggested a beneficial effect on renal function but, since levels fell in the normal ranges in both groups, such hypothesis would need further studies to be addressed.
Prenatal nutrition supplementation and growth biomarkers in preadolescent Bangladeshi children: A birth cohort study
Authors: Siddiqua Towfida Jahan , Roy Anjan Kumar , Akhtar Evana , Haq Md. Ahsanul , Wagatsuma Yukiko , Ekström Eva‐Charlotte , Afsar Md. Nure Alam , Hossain Md. Iqbal , Ahmed Tahmeed , El Arifeen Shams , Raqib Rubhana 
Published: September 2021

AbstractLittle is known about the usefulness of biomarkers to study the influence of prenatal nutrition supplementation in improving child growth. Anthropometry is not always straightforward to understand how nutrition might impact growth, especially in settings with high rates of malnutrition and infections. We examined the effects of prenatal supplementation on growth and growth biomarkers and the relationship between anthropometric measures and growth biomarkers of children at 4.5 and 9 years of age. Children were enrolled from a longitudinal cohort, where mothers were randomized into daily supplementation with either early‐food (≤9 gestation week [GW]) or usual‐food (~20 GW) (608 kcal 6 days/week); they were further randomized to receive 30‐mg or 60‐mg iron with 400‐μg folic acid, or multiple micronutrients (MM) in rural Bangladesh. Anthropometric data were collected from mothers at GW8 and children at 4.5 (n = 640) and 9 years (n = 536). Fasting blood was collected from children at each age. Early‐food supplementation showed reduced stunting and underweight at 4.5 and 9 years age respectively compared to usual‐food. Prenatal supplementations did not have any effect on growth biomarkers except for STAT5b expression which was lower in the early‐food compared to the usual‐food group (β = −0.21; 95 CI% = −0.36, −0.07). Plasma concentrations of 25‐hydroxy vitamin D and calcium were both inversely associated with weight‐for‐age and body mass index‐for‐age Z‐scores at 9 years, particularly in early‐food and MM groups. Although there was minimal effect on child growth by prenatal supplementations, the associations of biomarkers with anthropometric indices were predominantly driven by timing of food or MM supplementations.
Is there an association between necrotizing enterocolitis in premature neonates and functional gastrointestinal disorders later in childhood?
Authors: Rallis Dimitrios , Saliakellis Efstratios , Kaselas Christos , Malakozi Marina , Spyridakis Ioannis , Fotoulaki Maria , Diamanti Elisavet , Tsakalidis Christos 
Published: September 2021

AbstractBackgroundStressful events during infancy may predispose to the development of functional gastrointestinal disorders (FGIDs) in childhood.AimsTo evaluate the association of necrotizing enterocolitis (NEC) with childhood FGIDs.MethodsWe conducted a study, comparing 29 children of eight to ten years with a history of NEC with 58 children with no history of NEC. Subjects were assessed for FGIDs, based on Rome‐III criteria.ResultsAmong 29 subjects with NEC, 17 had surgical and 12 conservative NEC. Subjects with surgically, or conservatively managed NEC developed FGIDs at a significantly higher proportion, as compared to children with no history of NEC, later in childhood (41%, 33%, and 13% respectively, p = 0.033). Functional constipation was the most frequently identified disorder (35%, 33%, and 7% respectively). A significant association was detected between FGIDs and the history of perinatal stress (p = 0.049), NEC (p = 0.011), and the surgical management of NEC (p = 0.015).ConclusionsOur study suggests that there is a potential association between NEC and FGIDs later in childhood with functional constipation being the most frequently identified disorder.
Oxycodone target concentration dosing for acute pain in children
Authors: Morse James D , Hannam Jacqueline A , Anderson Brian J , Kokki Hannu , Kokki Merja 
Published: September 2021

AbstractBackgroundOxycodone pharmacokinetics have been described in premature neonates through to obese adults. Covariate influences have been accounted for using allometry (size) and maturation of oxycodone clearance with age. The target concentration is dependent on pain intensity that may differ over pain duration or between individuals.MethodsWe assumed a target concentration of 35 mcg.L−1 (acceptable range ±20%) to be associated with adequate analgesia without increased risk of adverse effects from respiratory depression. Pharmacokinetic simulation was used to estimate dose in neonates through to obese adults given intravenous or parenteral oxycodone.ResultsThere were 84% of simulated oxycodone concentrations within the acceptable range during maintenance dosing. Variability around the simulated target concentration decreased with age.The maturation of oxycodone clearance is reflected in changes to context‐sensitive halftime where clearance is immature in neonates compared with older children and adults. The intravenous loading and maintenance doses for a typical 5‐year‐old child are 100 mcg.kg−1 and 33 mcg.kg−1.h−1. In a typical adult, the loading dose is 100 mcg.kg−1 and maintenance dose 23 mcg.kg−1.h−1.ConclusionSimulation was used to suggest loading and maintenance doses to attain an oxycodone concentration of 35 mcg.L−1 predicted in adults. Although the covariates age and weight contribute 92% variability for clearance, there remains variability accounting for 16% of concentrations outside the target range. Duration of analgesic effect after ceasing infusion is anticipated to be longer in neonates where context‐sensitive halftime is greater than older children and adults.
Population pharmacokinetics of oxycodone: Premature neonates to adults
Authors: Morse James D , Sundermann Milan , Hannam Jacqueline A , Kokki Hannu , Kokki Merja , Anderson Brian J 
Published: September 2021

AbstractBackgroundOxycodone is used in children and adults for the control of acute postoperative pain. Covariate influences such as age, size, and fat mass on oxycodone pharmacokinetic parameters over the human lifespan are poorly quantified.MethodsPooled oxycodone time‐concentration profiles were available from preterm neonates to adults. Data from intravenous, intramuscular, buccal, and epidural formulations were analyzed using nonlinear mixed‐effects models. Normal fat mass was used to determine the influence of fat on oxycodone pharmacokinetics. Theory‐based allometry was used to scale pharmacokinetic parameters to a 70 kg individual. A maturation function described the increase in clearance in neonates and infants.ResultsThere were 237 subjects (24 weeks postmenstrual age to 75 years; 0.44–110 kg) providing 1317 plasma concentrations. A three‐compartment model with first‐order elimination best described oxycodone disposition. Population parameter estimates were clearance (CL) 48.6 L.h−1.70 kg−1 (CV 71%); intercompartmental clearances (Q2) 220 L.h−1.70 kg−1 (CV 64%); Q3 1.45 L.h−1.70 kg−1; volume of distribution in the central compartment (V1) 98.2 L.70 kg−1 (CV 76%); rapidly equilibrating peripheral compartment (V2) 90.1 L. 70 kg−1 (CV 76%); slow equilibrating peripheral compartment (V3) 28.9 L.70 kg−1. Total body weight was the best size descriptor for clearances and volumes. Absorption halftimes (TABS) were: 1.1 minutes for intramuscular, 70 minutes for epidural, 82 minutes for nasogastric, and 159.6 minutes for buccal administration routes. The relative bioavailability after nasogastric administration was 0.673 with a lag time of 8.7 minutes.ConclusionsClearance matured with age; 8% of the typical adult value at 24 weeks postmenstrual age, 33% in a term neonate and reached 90% of the adult clearance value by the end of the first year of life. Allometric scaling using total body weight was the better size descriptor of oxycodone clearance than fat‐free mass.
Green light reduces elongation when partially replacing sole blue light independently from cryptochrome 1a
Authors: Zhang Xue , Bisbis Mehdi , Heuvelink Ep , Jiang Weijie , Marcelis Leo F. M. 
Published: August 2021

AbstractAlthough green light is sometimes neglected, it can have several effects on plant growth and development. Green light is probably sensed by cryptochromes (crys), one of the blue light photoreceptor families. The aim of this study is to investigate the possible interaction between green and blue light and the involvement of crys in the green light response of plant photomorphogenesis. We hypothesize that green light effects on morphology only occur when crys are activated by the presence of blue light. Wild‐type Moneymaker (MM), cry1a mutant (cry1a), and two CRY2 overexpressing transgenic lines (CRY2‐OX3 and CRY2‐OX8) of tomato (Solanum lycopersicum) were grown in a climate chamber without or with green light (30 μmol m−2 s−1) on backgrounds of sole red, sole blue and red/blue mixture, with all treatments having the same photosynthetic photon flux density of 150 μmol m−2 s−1. Green light showed no significant effects on biomass accumulation, nor on leaf characteristics such as leaf area, specific leaf area, and chlorophyll content. However, in all genotypes, green light significantly decreased stem length on a sole blue background, whereas green light hardly affected stem length on sole red and red/blue mixture background. MM, cry1a, and CRY2‐OX3/8 plants all exhibited similar responses of stem elongation to green light, indicating that cry1a, and probably cry2, is not involved in this green light effect. We conclude that partially replacing blue light by green light reduces elongation and that this is independent of cry1a.
Review of shell waste reutilization to promote sustainable shellfish aquaculture
Authors: Zhan Junxiong , Lu Jinshan , Wang Di 
Published: September 2021

AbstractShellfish aquaculture has developed rapidly, and the annual production of shell waste by‐products exceeds 10 million tons. The reutilization of shell waste is a severe problem in terms of environmental protection and the development of the circular economy. Due to its limited economic value, shell waste has generally been discarded or sent to landfill without any further processing and reutilization, thereby wasting resources and severely degrading the coastal ecosystem. This review summarizes recent research into the reutilization of shell waste, including applications in the fields of agriculture, construction, environmental protection, chemical production, food additives and biomaterials. Problems and strategies related to the reutilization of shell waste are analysed in order to provide technical support for the large‐scale and high value‐added utilization of shell waste.
Air pollution and the productivity of high‐skill labor: evidence from court hearings*
Authors: Sarmiento Luis 
Published: September 2021

AbstractThe influence of air pollution on cognitive productivity is a highly relevant and not fully understood economic issue. This study provides evidence of an adverse effect of exposure on the productivity of Mexican judicial workers. The empirical strategy approximates productivity with the length of the hearing and infers causality through instrumental variable panel models. Results show that air pollution decreases the productivity of judicial workers. For instance, increasing particulate matter by 10 units raises the length of hearings by 6.7 percent. Back‐of‐the‐envelope calculations suggest that if particulate matter had been ten units lower, the sample of courthouses would have gained 81,712 minutes or roughly 56 work‐days between 2015 and 2017.
Race and inequality at work: An occupational perspective
Authors: Nelson Jennifer L. , Vallas Steven P. 
Published: September 2021

AbstractRecent research on racial inequality at work offers fruitful insights on the organizational conditions that reproduce racial segregation, racial disparities in wages, and racial hierarchies in the labor market and the workplace. Much less is known, however, about the specifically occupational influences that impinge on equitable work outcomes by race. In this paper, we explore three processes at the occupational level that relate to racial segregation, racialized access to resources, and status in one's line of work. We review research on racial inequality at work over the last 20 years to elucidate what is known, and remains to be seen, about these occupational processes. First, we review how occupational members get selected, and attempt to self‐select, into occupations via recruitment, licensing, credentialing, or certifications. Second, we consider how occupational incumbents teach, govern and evaluate new entrants, and with what consequences for racial inclusion/exclusion and retention in careers. Third, we examine research on client‐ or service‐based work, and highlight how workers navigate not only their roles, but also racial dynamics, vis‐a‐vis clients. We conclude with suggestions for how future research can harness occupational analysis to advance understanding of racial inequality at work.