bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Di-(2-Ethylhexyl) Phthalate At Environmentally Relevant Concentrations On Oxidative Stress and Lipid Metabolism in Livers of Male Xenopus Tropicalis
Authors: Pan Xinying , Zheng Li , Ding Yong , Dai Zhuo , Qi Xufeng , Zhang Xiaochun , Xu Yanbin , Xie Guangyan , Qiao Qingxia 
Published: November 2021

Abstract
Di-(2-ethylhexyl) phthalate (DEHP), used as a popular plasticizer to enhance the flexibility of plastics, is a major pollutant in aquatic environments. DEHP poses severe risks to aquatic organisms since it is an endocrine-disrupting compound. To comprehensively evaluate the toxicity of DEHP on the growth and livers of male X. tropicalis, sexually mature male X. tropicalis were exposed to environmentally relevant concentrations of DEHP, 0.2, 0.6, 1.8, 5.4 mg/L, for 49 days. The results showed that DEHP had a severe toxic effect on the livers of male X. tropicalis. Histopathological analysis of livers in all the DEHP-exposed groups showed changes in terms of vacuolization, loose cell cords, and an increasing amount of melanin. Large lipid droplets were markedly formed, and there were changes in the mitochondrial morphology upon DEHP exposure. In addition, oxidative stress was induced through the suppression of biochemical indicators and the downregulation in the mRNA expression of genes (nrf2, cat, sod, gst, and gpx) related to oxidative stress. A reduction in expression of fatty acid metabolism-related genes (pparα) was seen post-DEHP exposure. Thus, our study suggests that the hepatotoxicity induced by DEHP could be attributed to oxidative stress and disordered fatty acid metabolism. In conclusion, long-term exposure to DEHP at environmentally relevant concentrations poses ecological risks to aquatic organisms, which serves as a reminder that the application of DEHP and other plasticizers should be limited.
Circulating miRNAs and Cytokines Uncover Novel Physiopathological Mechanisms of COVID-19
Authors: Martínez-Fleta Pedro , Vera-Tomé Paula , Jiménez-Fernández María , Requena Silvia , Roy-Vallejo Emilia , Sanz-García Ancor , Lozano-Prieto Marta , López-Sanz Celia , Vara Alicia , Lancho-Sánchez Ángel , Martín-Gayo Enrique , Muñoz-Calleja Cecilia , Alfranca Arantzazu , González-Álvaro Isidoro , Galván-Román José María , Aspa Javier , Fuente Hortensia de la , Sanchez-Madrid Francisco 
Published: November 2021

Abstract
Coronavirus Disease 2019 (COVID-19) pneumonia is a life-threatening infectious disease, especially for elderly patients with multiple comorbidities. Despite enormous efforts to understand its underlying etiopathogenic mechanisms, most of them remain elusive. In this study, we compared differential plasma miRNAs and cytokines profiles between COVID-19 and other community-acquired pneumonias (CAP). A first screening and subsequent validation assays in an independent cohort of patients revealed a signature of 15 dysregulated miRNAs between COVID-19 and CAP patients. Additionally, multivariate analysis displayed a combination of 4 miRNAs (miR-106b-5p, miR-221-3p, miR-25-3p and miR-30a-5p) that significantly discriminated between both pathologies. Search for targets of these miRNAs, combined with plasma protein measurements, identified a differential cytokine signature between COVID-19 and CAP that included EGFR, CXCL12 and IL-10. Significant differences were also detected in plasma levels of CXCL12, IL-17, TIMP-2 and IL-21R between mild and severe COVID-19 patients. These findings provide new insights into the etiopathological mechanisms underlying COVID-19.
Adaptive Control of the Metalworking Process With Using Sound Generated During Cutting
Authors: Nahornyi Volodymyr , Panda Anton , Valíček Jan , Harnicarova Marta , Kušnerová Milena , Pandová Iveta , Legutko Stanislaw , Palková Zuzana , Lukáč Ondrej 
Published: November 2021

Abstract
The presented paper proposes a method of adaptive control of the metal cutting process based on the analysis and interpretation of recorded sound for the identification of the cutting process. The presented research results clearly demonstrated the efficiency of using the sound generated during cutting by CNC lathe 16 K20T1 for the adaptive metalworking control. The sound makes it possible to control the accuracy of the workpiece part geometry and the surface quality in the online mode. The online mode also makes it possible to make an informed decision about a timely interruption of the cutting process or the continuation of the process in the altered modes for its successful completion. As the research results presented in the paper show, there is a close correlation between the sound generated by cutting and the roughness of the surface being machined or the degree of wear of the cutting tool. The correlation between the sound and roughness of the machined surface is 0.94, whereas between the sound and wear of the cutting tool is 0.93. The paper aims to use the generated sound as operational information needed for adaptive control of the metal processing process and timely monitoring and diagnostics of the condition of processed materials using the precision index, newly introduced as the machining quality index.
Research On Fuel Compensation Control of High-pressure Common-Rail Diesel Engine Based On Crankshaft Segment Signals
Authors: Wang Yuhua , Wang Guiyong , Yao Guozhong , Shen Lizhong , He Shuchao 
Published: November 2021

Abstract
This paper studies the high-pressure common-rail diesel engine fuel supply compensation based on crankshaft fragment signals in order to improve the uneven phenomenon of diesel engine fuel supply and realize high efficiency and low pollution combustion. The experiments were conducted on a diesel engine with the model of YN30CR. Based on the characteristics of crankshaft fragment signals, the proportional integral (PI) control algorithm was used to quantify the engine working nonuniformity and extract the missing degree of fuel injection. The quantization method of each cylinder working uniformity and algorithm of fuel compensation control (FOC) based on crankshaft fragment signal were established, and the control strategy of working uniformity at different operating conditions was put forward. According to the principle of FOC control, a FOC control software module for ECU was designed. The FOC software module was simulated on ASCET platform. The results show that: Compared with the traditional quantization method, the oil compensation information extracted from crankshaft fragment signal has stronger anti-interference and more accurate parameters. FOC algorithm can accurately reflect the engine's working nonuniformity, and the control of the nonuniformity is reasonable. The compensation fuel amount calculated by FOC is high consistency with the fuel supply state of each cylinder set by experiment, which meets the requirement of accurate fuel injection control of common-rail diesel engine.
Tumor Volume Reduction Rate to Induction Chemotherapy Is a Prognostic Factor for Locally Advanced Head and Neck Squamous Cell Carcinoma: a Retrospective Cohort Study
Authors: Huang Chi-hsien , Lin Ting-Chun , Lien Ming-Yu , Cheng Fu-Ming , Li Kai-Chiun , Lin Chih-Yuan , Wang Ti-Hao 
Published: November 2021

Abstract
BackgroundAim of this study was to evaluate the prognostic of tumor volume reduction rate (TVRR) status post induction chemotherapy (IC) in LA-HNSCC.MethodsPatients with newly diagnosed LA-HNSCC from year 2007 to 2016 at a single center were included in this retrospective study. All patients had received IC as TPF (taxotere, platinum, fluorouracil) followed by daily definitive intensity-modulated radiotherapy (IMRT) for 70 Gy in 35 fractions concurrent with or without cisplatin-based chemotherapy. Tumor volume reduction rate of the primary tumor (TVRR-T) and lymph node (TVRR-N) was measured and calculated by contrast-enhanced CT images at diagnosis, and one month after final IC cycle, and analyzed though a univariate and multivariate Cox regression model.ResultsNinety patients of the primary cancer sites at hypopharynx (31/90, 34.4%), oropharynx (29/90, 32.2%), oral cavity (19/90, 21.1%) and larynx (11/90, 12.2%) were included in this study, with a median follow-up time interval of 3.9 years. In univariate Cox regression analysis, the TVRR-T as the only variable showed a significant difference for disease-free survival (DFS) (hazard ratio [HR] 0.77, 95% confidence interval (CI) 0.63 to 0.96; P = 0.02), aside from cancer site, RECIST, age and IC dose. In multivariate Cox regression analysis, The TVRR-T was also an independently significant prognostic factor for DFS (HR 0.77, 95% CI 0.62 to 0.97; P = 0.02). At a cutoff value using TVRR-T of 50% in Kaplan-Meier survival analysis, the DFS was significant higher with TVRR-T ≥ 50% group (log-rank test, p = 0.024), and also a trend of improved OS. (log-rank test, p = 0.069).ConclusionsTVRR-T was related to improved DFS and trend of improved OS. Other factors including patient’s age at diagnosis, the primary cancer site, and RECIST, were not significantly related to DFS.
Study of the Combustion , Pyrolysis Characteristics and Synergistic Effect of Co-hydrocharsation Products of Oil Shale and Rice HuskStudy of the Combustion , Pyrolysis Characteristics and Synergistic Effect of Co-hydrocharsation Products of Oil Shale and Rice Husk
Authors: LIU Yaoxin , Wang Enyu , KAN Ze 
Published: November 2021

Abstract
Under the pressure of environmental problems and fossil energy shortage, countries all over the world are looking for fuel to replace fossil energy. Oil shale and rice husk are potential fuels, but they both have some problems, such as high ash content and low calorific value .In the present study,oil shale and rice husk were used as feedstock for the high quality fuel through hydrothermal approach,it provides a new way for the resource utilization of oil shale and rice.Thermogravimetric method was used to analyze the functional groups change and thermal transformation characteristics of mixed hydrochars prepared for oil shale(OS) and rice husk(RH) at different hydrothermal temperatures(150,200 and 250℃), including combustion and pyrolysis processes, and analyze the synergistic effects. Results showed that the co-hydrocharsization pretreatment had a significant effect on the thermal transformation behavior of oil shale and rice husk.On the one hand, the mixture of hydrocar has higher volatile content than its calculated value.On the other hand,a synergistic effect(promoting combustion and pyrolysis behavior) was found in both combustion and pyrolysis processes, and this effect was the most obvious when the hydrothermal temperature was around 200℃,and the characteristic peak of functional groups vibration was strong.Since the synergistic effect of pyrolysis process is lower than that of combustion process, co-hydrocharsation products are considered to be more suitable for combustion.These findings have positive significance of energy generation and utilization of organic waste by the combination of co-hydrocharsization modification and subsequent thermochemical process.
TonB-dependent receptor epitopes expressed in M. bovis BCG induced significant protection in the hamster model of leptospirosis
Authors: Bettin Everton Burlamarque , Dorneles Jessica , Hecktheuer Amanda Silva , Madruga Andriele Bonemann , Neto Amilton Clair Pinto Seixas , McBride Alan John Alexander , Oliveira Thais Larré , Grassmann André Alex , Dellagostin Odir Antônio 
Published: November 2021

Abstract
Leptospirosis is an emerging infectious disease caused by pathogenic Leptospira spp. A universal vaccine against leptospirosis is likely to require highly conserved epitopes from pathogenic leptospires, that are exposed on the bacterial surface, and that generate a protective and sterilizing immune response. Our group recently identified several genes predicted to encode TonB-dependent receptors (TBDR) in Leptospira interrogans using a reverse vaccinology approach. Three leptospiral TBDRs were previously described and partially characterized as ferric-citrate, hemin, and cobalamin transporters. In the current study, we designed a fusion protein composed of predicted surface-exposed epitopes from three conserved leptospiral TBDRs. Based on their three-dimensional structural models and the prediction of immunogenic regions, nine putative surface-exposed fragments were selected to compose a recombinant chimeric protein. A Mycobacterium bovis BCG strain expressing this chimeric antigen encoded in the pUP500/PpAN mycobacterial expression vector was used to immunize Syrian hamsters. All animals (20/20) vaccinated with recombinant BCG survived infection with a endpoint dose of L. interrogans (P < 0.001). No animal survived in the negative control group. Immunization with our recombinant BCG elicited a humoral immune response against leptospiral TBDRs, as demonstrated by ELISA and immunoblot. No leptospiral DNA was detected by lipL32 qPCR in the kidneys of vaccinated hamsters. Similarly, no growth was observed in macerated kidney cultures from the same animals, suggesting the induction of a sterilizing immune response. Design of new vaccine antigens based on the structure of outer membrane proteins is a promising approach to overcome the impact of leptospirosis by vaccination.
Adequate Soliton Solutions to the Space-Time Fractional Telegraph Equation and Modified Third-Order KdV Equation through A Reliable Technique
Authors: Sadia Ummay , Arefin Mohammad Asif , Inc Mustafa , Uddin M. Hafiz 
Published: November 2021

Abstract
The space-time fractional telegraph equation and the space-time fractional modified third-order Kdv equations are significant molding equations in theoretic physics, mathematical physics, plasma physics also other fields of nonlinear sciences. The space time-fractional telegraph equation, which appears in the investigation of an electrical communication line and includes voltage in addition to current which is dependent on distance and time, is also applied to communication lines of wholly frequencies, together with direct current, as well as high-frequency conductors, audio frequency (such as telephone lines), and low frequency (for example cable television) used in the extension of pressure waves into the lessons of pulsatory blood movement among arteries also the one-dimensional haphazard movement of bugs towards an obstacle. The presence of chain rule and the derivative of composite functions allows the nonlinear fractional differential equations (NLFDEs) to translate into the ordinary differential equation employing wave alteration. To explore such categories of resolutions, the extended tanh-method is accomplished via Conformable fractional derivatives. A power sequence in tanh was originally used as an ansatz to provide analytical solutions of the traveling wave type of certain nonlinear evolution equations. To convert this problem to a standard differential equation, a partial complex transformation that has been summarized succinctly is utilized correctly thus, with all of the free parameters, numerous exact logical arrangements are required. The results are found as hyperbolic and rational functions involving parameters, when specific values are supplied to the parameters solitary wave solutions are formed from traveling wave solutions. The outcomes achieved in this study are king type, single soliton, double soliton, multiple solitons, bell shape, and other sorts of forms and we demonstrated that these solutions were validated through the Maple software. The proposed approach for solving nonlinear fractional partial differential equations has been developed to be operative, unpretentious, quick, and reliable to usage.
Numerical Analysis in Ultrasonic Elliptical Vibration Cutting (UEVC) Combined With Electrical Discharge Cutting (EDC) For Ti6Al4V
Authors: Kurniawan Rendi , Xu Moran , Li Chang Ping , Park Gun Chul , Kwak Ye In , Chen Jielin , Ko Tae Jo 
Published: November 2021

Abstract
This paper reports the numerical analysis results of ultrasonic elliptical vibration cutting (UEVC) combined with the electrical discharge cutting (EDC), called UEVC+EDC. UEVC delivers decreasing cutting forces, repressing side-burrs, and lowering tool wear. EDC is a cutting technique using a pulsed spark to remove material using thermal energy. Difficult-to-cut materials, such as Ti-6Al-4V, can be cut effectively by combining these two techniques. A numerical study was performed using ABAQUS finite element analysis (FEA) software by investigating the von Mises stress, cutting forces, and temperature. Numerical analysis was carried out by modifying the ultrasonic vibration frequency, distance of the discharge pulse, discharge voltage, and discharge pulse radius. UEVC+EDC was compared numerically and experimentally with regular cutting (NC) and UEVC in terms of cutting force and tool temperature. The results showed that the UEVC+EDC method could improve the cutting condition by reducing the cutting force and von Mises stress and increasing the tool temperature.
COVID-19-Related Distress Predicts Analog PTSD Symptoms After Exposure to an Analog Stressor
Authors: Friesen Edith , Michael Tanja , Schäfer Sarah K. , Sopp M. Roxanne 
Published: November 2021

Abstract
The long-term impact of the COVID-19 pandemic on mental health is only starting to emerge. Beyond direct effects on mental health, it is crucial to investigate how negative psychological responses to the COVID-19 pandemic might affect etiological processes of different mental disorders. In the current online study, we investigated whether a negative psychological response to the pandemic might predispose individuals towards posttraumatic stress disorder (PTSD) development after exposure to a non-COVID-19-related traumatic stressor. Moreover, we examined if these effects are mediated by the strength of associative fear learning during trauma. Using an established analog procedure, we demonstrate that COVID-19-related distress predicts analog PTSD symptoms of a non-COVID-19-related stressor and that these effects are fully mediated by the strength of associative fear learning during exposure to the analog stressor. As such, our findings indicate that negative psychological responses to the COVID-19 pandemic should be considered as an emerging pretraumatic risk factor.
Prevention and treatment of lactostasis and (or) mastitis in the pediatric area: practical aspects
Authors: Safina A. I. 
Published: November 2021

Introduction. Incomplete breast emptying is the main cause of lactostasis, which can contribute to the development of mastitis. The article discusses the issues of prevention and treatment of lactostasis in breastfeeding mothers in the district covered by childhealth care: how to arrange breastfeeding, expression of breast milk, regime issues from the baby’s first days, as well as present-day knowledge on breast milk microbiota dysbiosis and an option of probiotic therapy. Clinical cases are presented.Clinical case 1. A breastfeeding mother found breast lumps on the one side 2 weeks after her labour. Lactostasis was diagnosed, it was caused by inappropriate breastfeeding technique. The breastfeeding mother was provided with the recommendations for proper performance of breastfeeding technique and prescribed the drug therapy: ibuprofen 400 mg once at fever ≥ 38.5 ºC and Lactobacillus fermentum CEST5716 – 1 capsule once daily. On the 3rd day, her health state significantly improved, the pain reduced, the temperature returned to normal, the breast lumps practically disappeared, on the 5th day the pain and breast lumps completely disappeared.Clinical case 2. A breastfeeding mother, first labour, 2 months have passed since her labour, exclusively breastfeeding on demand, complaints of pain in the left breast, local hyperemia 3 x 3 cm occurred, no breast lumps, local pain elicited by palpation, fever of 37.2 ºC. The breastfeeding mother was diagnosed with lactostasis, she was provided with recommendations for the arrangement of breastfeeding and expression of breast milk; not proscribed with antibacterial therapy, but the therapy with Lactobacillus fermentum CEST5716, 1 capsule once daily for 1 month. A day later, her health state improved: the pain reduced, the hyperemia disappeared, her body temperature returned to normal. The patient was recommended non-drug measures for preventing lactostasis and continuous administration of Lactobacillus fermentum CEST5716 – 1 capsule daily for 1 month.Clinical case 3. A breastfeeding mother detected daily lactostasis in her right breast 3 months after her labour. It might had been caused by chest contusion before the onset of the 1st episode of lactostasis. Medical examination revealed calcifications in her breast duct. Against the background of non-drug therapy, the patient adminstered Lactobacillus fermentum CEST5716 – 1 capsule daily, which resulted in a positive effect in a week’s time. The follow-up observation showed that lactostasis completely resolved without relapses in a 1.5-months’ time.Сonclusion. The correct breastfeeding technique is key to the prevention of lactostasis and mastitis, and the use of probiotic therapy Lactobacillus fermentum CEST5716 is an effective and safe drug treatment.
Clinical and echographic signs of acute kidney injury in premature babies born with very low and extremely low body weight
Authors: Mironova A. K. , Osmanov I. M. , Zakharova I. N. , Pykov M. I. , Tumanova E. L. , Morozov S. L. , Vokuyeva T. I. 
Published: November 2021

Introduction. One of the urgent issues in the first stage of nursing premature infants is acute kidney injury. The incidence of neonatal acute kidney injury in developing countries is 3.9/1000 live births, with 34.5/1000 among neonatal intensive care patients.The aim of the study was to establish echographic signs of acute kidney injury in deeply premature infants in the neonatal period.Materials and methods. 24 children with clinical and laboratory signs of acute kidney injury “AKI+” and 76 children without signs of acute kidney injury “AKI-“. All the children included in the study were born with a body weight of less than 1500 g and a gestation period of less than 32 weeks and were in the neonatal intensive care unit. To clarify the nature of the detected changes, a scientific analysis of the results of pathoanatomic studies of 55 deceased preterm infants was carried out.Results. In all children from the “AKI+” group, there was a pronounced diffuse-uneven increase in the echogenicity of the parenchyma, there was a depletion of the vascular pattern in the subcapsular zone and/or in the cortical layer of the parenchyma, in 25% of patients on the 5th-15th day of life, anechogenic formations without signs of blood flow, with a diameter of 1-3 mm in the cortical layer were noted. The changes had a bilateral nature of the lesion, with further observation they were gradually reduced and by 3 ± 2 months of life they were not determined during ultrasound of the kidneys.Discussion. Acute kidney injury is an urgent problem of preterm infants born with very low and extremely low body weight. The article presents the results of ultrasound examination of the kidneys in comparison with clinical and laboratory indicators and the results of pathomorphological studies. As a result of the study, the most characteristic ultrasound signs of acute kidney injury were identified, which are an uneven diffuse increase in the echogenicity of the renal parenchyma, small anechoic avascular inclusions (cysts) of the parenchyma, depletion of renal blood flow.Conclusions. Renal ultrasonography is an informative method, but echographic changes may be labile depending on the clinical course of the disease, and the absence of anechogenic masses in the parenchyma may be due to technical limitations of the ultrasonography method. It requires further monitoring and continued vigilance of the pediatrician and pediatric nephrologist.