bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pilot study quantifying muscle glycosaminoglycan using bi-exponential T1ρ mapping in patients with muscle stiffness after stroke
Authors: Menon Rajiv G. , Raghavan Preeti , Regatte Ravinder R. 
Published: July 2021

AbstractPost stroke muscle stiffness is a common problem, which left untreated can lead to disabling muscle contractures. The purpose of this pilot study was to evaluate the feasibility of bi-exponential T1ρ mapping in patients with arm muscle stiffness after stroke and its ability to measure treatment related changes in muscle glycosaminoglycans (GAGs). Five patients with muscle stiffness after stroke and 5 healthy controls were recruited for imaging of the upper arm with 3D-T1ρ mapping. Patients were scanned before and after treatment with hyaluronidase injections, whereas the controls were scanned once. Wilcoxon Mann–Whitney tests compared patients vs. controls and patients pre-treatment vs. post-treatment. With bi-exponential modeling, the long component, T1ρl was significantly longer in the patients (biceps P = 0.01; triceps P = 0.004) compared to controls. There was also a significant difference in the signal fractions of the long and short components (biceps P = 0.03, triceps P = 0.04). The results suggest that muscle stiffness is characterized by increased muscle free water and GAG content. Post-treatment, the T1ρ parameters shifted toward control values. This pilot study demonstrates the application of bi-exponential T1ρ mapping as a marker for GAG content in muscle and as a potential treatment monitoring tool for patients with muscle stiffness after stroke.
Statistical modeling for bioconvective tangent hyperbolic nanofluid towards stretching surface with zero mass flux condition
Authors: Shafiq Anum , Lone S. A. , Sindhu Tabassum Naz , Al-Mdallal Q. M. , Rasool G. 
Published: July 2021

AbstractThis article presents the implementation of a numerical solution of bioconvective nanofluid flow. The boundary layer flow (BLF) towards a vertical exponentially stretching plate with combination of heat and mass transfer rate in tangent hyperbolic nanofluid containing microorganisms. We have introduced zero mass flux condition to achieve physically realistic outcomes. Analysis is conducted with magnetic field phenomenon. By using similarity variables, the partial differential equation which governs the said model was converted into a nonlinear ordinary differential equation, and numerical results are achieved by applying the shooting technique. The paper describes and addresses all numerical outcomes, such as for the Skin friction coefficients (SFC), local density of motile microorganisams (LDMM) and the local number Nusselt (LNN). Furthermore, the effects of the buoyancy force number, bioconvection Lewis parameter, bioconvection Rayleigh number, bioconvection Pecelt parameter, thermophoresis and Brownian motion are discussed. The outcomes of the study ensure that the stretched surface has a unique solution: as Nr (Lb) and Rb (Pe) increase, the drag force (mass transfer rate) increases respectively. Furthermore, for least values of Nb and all the values of Nt under consideration the rate of heat transfer upsurges. The data of SFC, LNN, and LDMM have been tested utilizing various statistical models, and it is noted that data sets for SFC and LDMM fit the Weibull model for different values of Nr and Lb respectively. On the other hand, Frechet distribution fits well for LNN data set for various values of Nt.
The effect of deadlines on cancer screening completion: a randomized controlled trial
Authors: Lieberman Alicea , Gneezy Ayelet , Berry Emily , Miller Stacie , Koch Mark , Argenbright Keith E. , Gupta Samir 
Published: July 2021

AbstractCancer is the second leading cause of death in the United States. Although screening facilitates prevention and early detection and is one of the most effective approaches to reducing cancer mortality, participation is low—particularly among underserved populations. In a large, preregistered field experiment (n = 7711), we tested whether deadlines—both with and without monetary incentives tied to them—increase colorectal cancer (CRC) screening. We found that all screening invitations with an imposed deadline increased completion, ranging from 2.5% to 7.3% relative to control (ps < .004). Most importantly, individuals who received a short deadline with no incentive were as likely to complete screening (9.7%) as those whose invitation included a deadline coupled with either a small (9.1%) or large declining financial incentive (12.0%; ps = .57 and .04, respectively). These results suggest that merely imposing deadlines—especially short ones—can significantly increase CRC screening completion, and may also have implications for other forms of cancer screening.
Revisiting extraprostatic extension based on invasion depth and number for new algorithm for substaging of pT3a prostate cancer
Authors: Park Cheol Keun , Chung Yeon Seung , Choi Young Deuk , Ham Won Sik , Jang Won Sik , Cho Nam Hoon 
Published: July 2021

AbstractExtraprostatic extension (EPE) is a factor in determining pT3a stage in prostate cancer. However, the only distinction in EPE is whether it is focal or non-focal, causing diagnostic and prognostic ambiguity. We substaged pT3a malignancies using classification of EPE to improve personalized prognostication. We evaluated 465 radical prostatectomy specimens with a digital image analyzer by measuring the number, radial distance and two-dimensional square area of the EPE. The most significant cut-off value was proposed as an algorithm for the pT3a substaging system to predict biochemical recurrence (BCR). A combination of the radial distance and the number of EPEs predicted BCR the most effectively. The optimal cut-off criteria were 0.75 mm and 2 mm in radial distance and multifocal EPE (hazard ratio: 2.526, C-index 0.656). The pT3a was subdivided into pT3a1, < 0.75 mm and any number of EPEs; pT3a2, 0.75–2 mm and one EPE; and pT3a3, > 2 mm and any number of EPEs or 0.75–2 mm and ≥ 2 EPEs. This combined tier was highly significant in the prediction of BCR-free survival. The combination of radial distance and number of EPEs could be used to subdivide pT3a prostate cancer and may aid in the prediction of BCR.
A scDb-based trivalent bispecific antibody for T-cell-mediated killing of HER3-expressing cancer cells
Authors: Aschmoneit Nadine , Steinlein Sophia , Kühl Lennart , Seifert Oliver , Kontermann Roland E. 
Published: July 2021

AbstractHER3 is a member of the EGF receptor family and elevated expression is associated with cancer progression and therapy resistance. HER3-specific T-cell engagers might be a suitable treatment option to circumvent the limited efficacy observed for HER3-blocking antibodies in clinical trials. In this study, we developed bispecific antibodies for T-cell retargeting to HER3-expressing tumor cells, utilizing either a single-chain diabody format (scDb) with one binding site for HER3 and one for CD3 on T-cells or a trivalent bispecific scDb-scFv fusion protein exhibiting an additional binding site for HER3. The scDb-scFv showed increased binding to HER3-expressing cancer cell lines compared to the scDb and consequently more effective T-cell activation and T-cell proliferation. Furthermore, the bivalent binding mode of the scDb-scFv for HER3 translated into more potent T-cell mediated cancer cell killing, and allowed to discriminate between moderate and low HER3-expressing target cells. Thus, our study demonstrated the applicability of HER3 for T-cell retargeting with bispecific antibodies, even at moderate expression levels, and the increased potency of an avidity-mediated specificity gain, potentially resulting in a wider safety window of bispecific T-cell engaging antibodies targeting HER3.
Optimized photoluminescence quantum yield in upconversion composites considering the scattering, inner-filter effects, thickness, self-absorption, and temperature
Authors: Jones Callum M. S. , Biner Daniel , Misopoulos Stavros , Krämer Karl W. , Marques-Hueso Jose 
Published: July 2021

AbstractOptimizing upconversion (UC) composites is challenging as numerous effects influence their unique emission mechanism. Low scattering mediums increase the number of dopants excited, however, high scattering mediums increase the UC efficiency due to its non-linear power dependency. Scattering also leads to greater thermal effects and emission saturation at lower excitation power density (PD). In this work, a photoluminescence quantum yield (PLQY) increase of 270% was observed when hexagonal NaYF4:(18%)Yb3+,(2%)Er3+ phosphor is in air compared to a refractive index-matched medium. Furthermore, the primary inner-filter effect causes a 94% PLQY decrease when the excitation focal point is moved from the front of the phosphor to 8.4 mm deep. Increasing this effect limits the maximum excitation PD, reduces thermal effects, and leads to emission saturation at higher excitation PDs. Additionally, self-absorption decreases the PLQY as the phosphor’s thickness increases from 1 to 9 mm. Finally, in comparison to a cuboid cuvette, a 27% PLQY increase occurs when characterizing the phosphor in a cylindrical cuvette due to a lensing effect of the curved glass, as supported by simulations. Overall, addressing the effects presented in this work is necessary to both maximize UC composite performance as well as report their PLQY more reliably.
Perivascular vital cells in the ablation center after multibipolar radiofrequency ablation in an in vivo porcine model
Authors: Poch F. G. M. , Neizert C. A. , Geyer B. , Gemeinhardt O. , Niehues S. M. , Vahldiek J. L. , Bressem K. K. , Lehmann K. S. 
Published: July 2021

AbstractMultibipolar radiofrequency ablation (RFA) is an advanced ablation technique for early stage hepatocellular carcinoma and liver metastases. Vessel cooling in multibipolar RFA has not been systematically investigated. The objective of this study was to evaluate the presence of perivascular vital cells within the ablation zone after multibipolar RFA. Multibipolar RFA were performed in domestic pigs in vivo. Three internally cooled bipolar RFA applicators were used simultaneously. Three experimental settings were planned: (1) inter-applicator-distance: 15 mm; (2) inter-applicator-distance: 20 mm; (3) inter-applicator-distance: 20 mm with hepatic inflow occlusion (Pringle maneuver). A vitality staining was used to analyze liver cell vitality around all vessels in the ablation center with a diameter > 0.5 mm histologically. 771 vessels were identified. No vital tissue was seen around 423 out of 429 vessels (98.6%) situated within the central white zone. Vital cells could be observed around major hepatic vessels situated adjacent to the ablation center. Vessel diameter (> 3.0 mm; p < 0.05) and low vessel-to-ablation-center distance (< 0.2 mm; p < 0.05) were identified as risk factors for incomplete ablation adjacent to hepatic vessels. The vast majority of vessels, which were localized in the clinically relevant white zone, showed no vital perivascular cells, regardless of vessel diameter and vessel type. However, there was a risk of incomplete ablation around major hepatic vessels situated directly within the ablation center. A Pringle maneuver could avoid incomplete ablations.
Triggering avalanches by transverse perturbations in a rotating drum
Authors: Salinas Vicente , Quiñinao Cristóbal , González Sebastián , Castillo Gustavo 
Published: July 2021

AbstractWe study the role of small-scale perturbations in the onset of avalanches in a rotating drum in the stick-slip regime. By vibrating the system along the axis of rotation with an amplitude orders of magnitude smaller than the particles’ diameter, we found that the order parameter that properly describes the system is the kinetic energy. We also show that, for high enough frequencies, the onset of the avalanche is determined by the amplitude of the oscillation, contrary to previous studies that showed that either acceleration or velocity was the governing parameter. Finally, we present a theoretical model that explains the transition between the continuous and discrete avalanche regimes as a supercritical Hopf bifurcation.
Dosimetry during adjuvant 131I therapy in patients with differentiated thyroid cancer-clinical implications
Authors: Szumowski Piotr , Abdelrazek Saeid , Iwanicka Dorota , Mojsak Małgorzata , Sykała Monika , Żukowski Łukasz , Siewko Katarzyna , Adamska Agnieszka , Maliszewska Katarzyna , Popławska-Kita Anna , Szelachowska Małgorzata , Krętowski Adam , Myśliwiec Janusz 
Published: July 2021

AbstractThe activity of radioiodine (131I) used in adjuvant therapy for thyroid cancer ranges between 30 mCi (1.1 GBq) and 150 mCi (5.5 GBq). Dosimetry based on Marinelli's formula, taking into consideration the absorbed dose in the postoperative tumour bed (D) should systematise the determination of 131I activity. Retrospective analysis of 57 patients with differentiated thyroid cancer (DTC) after thyreidectomy and adjuvant 131I therapy with the fixed activity of 3.7 GBq. In order to calculate D from Marinelli's formula, the authors took into account, among other things, repeated dosimetry measurements (after 6, 24, and 72 h) made during scintigraphy and after administration of the therapeutic activity or radioiodine. In 75% of the patients, the values of D were > 300 Gy (i.e. above the value recommended by current guidelines). In just 16% of the patients, the obtained values fell between 250 and 300 Gy, whereas in 9% of the patients, the value of D was < 250 Gy. The therapy was successful for all the patients (stimulated Tg < 1 ng/ml and 131I uptake < 0.1% in the thyroid bed in follow-up examination). Dosimetry during adjuvant 131I therapy makes it possible to diversify the therapeutic activities of 131I in order to obtain a uniform value of D.
Using spatial and temporal modeling to visualize the effects of U.S. state issued stay at home orders on COVID-19
Authors: Carroll Rachel , Prentice Christopher R. 
Published: July 2021

AbstractCoronavirus disease 2019 dominated and augmented many aspects of life beginning in early 2020. Related research and data generation developed alongside its spread. We developed a Bayesian spatio-temporal Poisson disease mapping model for estimating real-time characteristics of the coronavirus disease in the United States. We also created several dashboards for visualization of the statistical model for fellow researchers and simpler spatial and temporal representations of the disease for consumption by analysts and data scientists in the policymaking community in our region. Findings suggest that the risk of confirmed cases is higher for health regions under partial stay at home orders and lower in health regions under full stay at home orders, when compared to before stay at home orders were declared. These results confirm the benefit of state-issued stay at home orders as well as suggest compliance to the directives towards the older population for adhering to social distancing guidelines.
Morpho-molecular characterization of Gyrodactylus parasites of farmed tilapia and their spillover to native fishes in Mexico
Authors: García-Vásquez Adriana , Pinacho-Pinacho Carlos Daniel , Guzmán-Valdivieso Ismael , Calixto-Rojas Miguel , Rubio-Godoy Miguel 
Published: July 2021

AbstractTranslocation of fishes for aquaculture has resulted in the co-introduction of some of their parasites. African cichlid fishes, generically called “tilapias” have been introduced worldwide, along with their monogenean parasites. In a nation-wide survey, we characterised monogeneans of the genus Gyrodactylus infecting farmed “tilapia” throughout Mexico. We also collected native fishes around farms, to look for potential parasite spillover from cultured fishes. Monogeneans were identified taxonomically using morphological and molecular characters. Originally African, pathogenic Gyrodactylus cichlidarum was recorded in every farm surveyed, infecting different “tilapia” varieties, as well as three native cichlid fish species. Previously, we had shown that G. cichlidarum also infects native, non-cichlid fishes in Mexico. We also recorded that Gyrodactylus yacatli is widely distributed in Mexico, infecting cultured “tilapia” and native fishes; and present data indicating that this is a further translocated African parasite. A third, unidentified gyrodactylid infected farmed and native fishes in Chiapas, southern Mexico; we describe the new species as Gyrodactylus shinni n. sp., and provide evidence that this is a third monogenean translocated with African fish. The wide distribution of exotic parasites co-introduced with “tilapia” and their spillover to native fishes may have an important impact on the ichthyofauna in Mexico, one the world’s megadiverse countries.
Clinical features of pachyvessels associated with polypoidal choroidal vasculopathy in chronic central serous chorioretinopathy
Authors: Wang Te-An , Chan Wei-Chun , Tsai Shawn H. , Chen Lee-Jen 
Published: July 2021

AbstractTo investigate the association between clinical features of chronic central serous chorioretinopathy (CSC) and subsequent development of polypoidal choroidal vasculopathy (PCV). Characteristics and treatment response of PCV secondary to CSC were described. This retrospective observational study included 18 patients with chronic CSC (18 eyes) with subsequent PCV and 36 controls (36 eyes) with chronic CSC without PCV development during follow-up. Clinical features were compared between the two groups. A logistic regression model was used to evaluate the risk factor of PCV formation. Treatments for PCV included anti-vascular endothelial growth factor (VEGF) monotherapy, photodynamic therapy (PDT), or PDT and anti-VEGF combination treatment. Subretinal fluid on optical coherence tomography images were assessed after treatments. Significant between-group differences were observed in best-corrected visual acuity after disease resolution and presence of pachyvessels (P = .001 and P = .003, respectively). The presence of pachyvessels in chronic CSC was associated with subsequent PCV (odds ratio = 6.00; 95% CI, 1.74–20.68; P = .005). CSC recurrence and subfoveal choroidal thickness (SFCT) were not significantly associated with subsequent PCV development (P = .393 and P = .911, respectively). The mean age of PCV diagnosis was 51 years, and the mean time from CSC diagnosis to PCV confirmation was 77.8 months. The mean (range) SFCT of PCV was 327.7 (134–599) μm. Nine patients received anti-VEGF monotherapy and 5 had disease remission. Four patients received PDT and anti-VEGF combination treatment and all of the 4 had disease remission. In chronic CSC, pachyvessel characteristics are associated with subsequent PCV development. This result will assist clinicians to evaluate CSC in clinical practice and provide insights into the pathogenesis of PCV.
Prediction of optimal continuous positive airway pressure in Thai patients with obstructive sleep apnea
Authors: Saiphoklang Narongkorn , Leelasittikul Kanyada , Pugongchai Apiwat 
Published: July 2021

AbstractContinuous positive airway pressure (CPAP) is simple and effective treatment for obstructive sleep apnea (OSA) patients. However, the CPAP prediction equation in each country is different. This study aimed to predict CPAP in Thai patients with OSA. A retrospective study was conducted in Thai patients, who OSA was confirmed by polysomnography and CPAP titration from January 2015 to December 2018. Demographics, body mass index (BMI), neck circumference (NC), Epworth sleepiness scale, apnea–hypopnea index (AHI), respiratory disturbance index (RDI), mean and lowest pulse oxygen saturation (SpO2), and optimal pressure were recorded. A total of 180 subjects were included: 72.8% men, age 48.7 ± 12.7 years, BMI 31.0 ± 6.3 kg/m2, NC 40.7 ± 4.1 cm, AHI 42.5 ± 33.0 per hour, RDI 47.1 ± 32.8 per hour, and lowest SpO277.1 ± 11.0%. Multiple linear regression analysis identified NC, BMI, RDI, and lowest SpO2. A final CPAP predictive equation was: optimal CPAP (cmH2O) = 4.614 + (0.173 × NC) + (0.067 × BMI) + (0.030 × RDI) − (0.076 × lowest SpO2). This model accounted for 50.0% of the variance in the optimal pressure (R2 = 0.50). In conclusion, a CPAP prediction equation can be used to explain a moderate proportion of the titrated CPAP in Thai patients with OSA. However, the CPAP predictive equation in each country may be different due to differences of ethnicity and physiology.Trial registration: TCTR20200108003.
Comprehensive review of single stage switched boost inverter structures
Authors: Palanidoss Sriramalakshmi , Thazhathu Sreedevi Vellithiruthi , Bhaskar Mahajan Sagar , Kannan Ramani , Baboli Payam Teimourzadeh 
Published: July 2021

AbstractSingle‐stage switched boost inverter (SBI) with buck‐boost capability finds wide applications in renewable energy systems (RES). This paper aims at a comprehensive topological review of various single stage SBI circuits. The boosting techniques of SBI include switched inductor, switched capacitor, and transformer assisted switches. Each SBI derived structure has its own merits and demerits depending on the applications. The performance evaluation of SBIs, based on various perspectives like boost factor, voltage stress across active devices, passive elements count, DC link voltage, switching losses, voltage gain, and efficiency, are also discussed. A suitable modulation strategy is used to obtain the desired boosted and inverted ac output voltage in one stage SBI. Different modulation strategies adopted for SBIs are also included at the end of the topological review. This topological review's contribution enlightens the researchers in selecting appropriate SBI with effective modulation strategies suitable for renewable energy applications. Besides, the benefits and shortcomings of these converters are discussed in detail.
Grids of stellar models with rotation
Authors: Eggenberger Patrick , Ekström Sylvia , Georgy Cyril , Martinet Sébastien , Pezzotti Camilla , Nandal Devesh , Meynet Georges , Buldgen Gaël , Salmon Sébastien , Haemmerlé Lionel , Maeder André , Hirschi Raphael , Yusof Norhasliza , Groh José , Farrell Eoin , Murphy Laura , Choplin Arthur 
Published: July 2021

Context. Grids of stellar models, computed with the same physical ingredients, allow one to study the impact of a given physics on a broad range of initial conditions and they are a key ingredient for modeling the evolution of galaxies.
Aims. We present here a grid of single star models for masses between 0.8 and 120 M⊙, with and without rotation for a mass fraction of heavy element Z = 0.006, representative of the Large Magellanic Cloud (LMC).
Methods. We used the GENeva stellar Evolution Code. The evolution was computed until the end of the central carbon-burning phase, the early asymptotic giant branch phase, or the core helium-flash for massive, intermediate, and low mass stars, respectively.
Results. The outputs of the present stellar models are well framed by the outputs of the two grids obtained by our group for metallicities above and below the one considered here. The models of the present work provide a good fit to the nitrogen surface enrichments observed during the main sequence for stars in the LMC with initial masses around 15 M⊙. They also reproduce the slope of the luminosity function of red supergiants of the LMC well, which is a feature that is sensitive to the time-averaged mass loss rate over the red supergiant phase. The most massive black hole that can be formed from the present models at Z = 0.006 is around 55 M⊙. No model in the range of mass considered will enter into the pair-instability supernova regime, while the minimal mass to enter the region of pair pulsation instability is around 60 M⊙ for the rotating models and 85 M⊙ for the nonrotating ones.
Conclusions. The present models are of particular interest for comparisons with observations in the LMC and also in the outer regions of the Milky Way. We provide public access to numerical tables that can be used for computing interpolated tracks and for population synthesis studies.