bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of heat treatment on surface structure and gas sensing of electrospun ZnO‐SnO2 composite nanofibers
Authors: Wu Fengyu Y. , Tseng Wenjea J. 
Published: January 2021

AbstractZnO‐SnO2 composite nanofibers with a constant Zn/Sn ratio of 0.4 have been electrospun and calcined at 650°C in ambient air, followed then by heat treatment at 350°C in either air, 5% H2‐95% N2, or 15 ppm H2S‐air atmosphere for comparison of gas‐sensing behaviors. The nanofibers being heat‐treated in the H2S‐air atmosphere display a sensing response more than 25 times than the as‐calcined counterpart, that is, the sensing response increases from 20 to 514 against a model NO2 gas of 10 ppm concentration at a working temperature of 180°C. This appears to be attributable to the formation of sulfate on the nanofiber surface, which resulted in an enriched oxygen vacancy and chemisorbed oxygen near the surface for facilitating the redox reaction toward NO2 gas molecules. The facile heat treatment in the presence of dilute H2S concentration may have opened up an alternative route for enhancing the surface‐sensitive gas‐sensor activity.
Preparation and characterization of spray‐dried granulated bioactive glass micron spheres
Authors: Chen Liu‐Gu , Huang Yu‐Hsuan , Chou Yu‐Jen 
Published: January 2021

AbstractOwing to its superior bioactivity, biocompatibility, and biodegradability, bioactive glass (BG) has been attracting significant attention within biomedical science fields. However, BG powders with variable particle sizes are required targeting different applications, such as dermal fillers. Thus, in this study, granulated BG powders were prepared via the spray drying and granulation method. Size‐controlled BG micron sphere with diameters of up to tens of microns can be mass‐produced and their phase information, particle morphology, and specific surface area were characterized via X‐ray diffraction, scanning electron microscopy, and nitrogen adsorption/desorption isotherm, respectively. In addition, the in vitro bioactivity was evaluated following Kokubo's protocol, and the formation of a hydroxyapatite (HA) layer after immersion into the simulated body fluid was confirmed via energy‐dispersive and Fourier transform infrared spectroscopy. The cytotoxicity was examined using a 3‐(4, 5‐dimethylthiazol‐2‐yl)‐2, 5‐diphenyltetrazolium bromide assay. Finally, the resulting morphologies and corresponding properties are shown, and the related mechanisms are discussed.
A novel approach toward microstructure evaluation of sintered ceramic materials through image processing techniques
Authors: Chowdhury Sandipan , Dhara Dipika , Chowdhury Soumit , Haldar Partha , Chatterjee Kingshuk , Bhattacharya Tapas Kumar 
Published: January 2021

AbstractIn this paper, an image processing technique is introduced to measure the grain size and their distributions from the SEM image of copper oxide (CuO) and titanium dioxide (TiO2) doped sintered alumina ceramics accurately. The noise present in SEM image is removed by applying low pass Gaussian filter followed by suppression of regional minima over a threshold. The clarity of individual grains and grain boundaries have been done by applying Watershed transform to this preprocessed SEM image. Morphological operations like dilation and erosion are used to make the grain‐boundary edges clear and continuous. The individual grain size in µm scale is measured from the pixel length of the rectangular bounding box drawn around the segmented grain. The normal Gaussian type distribution of grain size is observed in both CuO‐ and TiO2‐doped grains in SEM image. The average grain size of CuO‐doped alumina grains (2.24 µm) is very close to G50 value (2.17 µm), but G50 value of TiO2‐doped grains (8.59 µm) is slightly higher than its average grain size (7.96 µm). The proposed algorithm is compared with linear intercept method and the grain sizes obtained are very close to each other.
Remodeling the chromatin landscape in T lymphocytes by a division of labor among transcription factors
Authors: Vahedi Golnaz 
Published: January 2021

AbstractAn extraordinary degree of condensation is required to fit the eukaryotic genome inside the nucleus. This compaction is attained by first coiling the DNA around structures called nucleosomes. Mammalian genomes are further folded into sophisticated three‐dimensional (3D) configurations, enabling the genetic code to dictate a diverse range of cell fates. Recent advances in molecular and computational technologies have enabled the query of higher‐order chromatin architecture at an unprecedented resolution and scale. In T lymphocytes, similar to other developmental programs, the hierarchical genome organization is shaped by a highly coordinated division of labor among different classes of sequence‐specific transcription factors. In this review, we will summarize the general principles of 1D and 3D genome organization, introduce the common experimental and computational techniques to measure the multilayer chromatin organization, and discuss the pervasive role of transcription factors on chromatin organization in T lymphocytes.
Sr3Lu (VO4)3: Eu3+ red‐emitting phosphors for warm white LEDs
Authors: Zhou Xianju , Zhang Jie , Chen Lingni , Li Yanhong , Xiang Guotao , Jiang Sha , Li Li , Tang Xiao , Cao Zhongmin , Xie Guangxin 
Published: January 2021

AbstractA series of novel red emission phosphors Sr3Lu1‐x(VO4)3:xEu3+(x = 0.007, 0.009, 0.02, 0.04, 0.06) were synthesized successfully by traditional high‐temperature solid‐state reaction. The results of X‐ray diffraction (XRD) reveal the doped Eu3+ ions have replaced the lattice sites of Lu3+ ions. The diffuse reflectance spectra illustrate the energy gap of Sr3Lu(VO4)3 host is 3.61 eV. The room‐temperature steady‐state fluorescence spectra show that these phosphors can be effectively pumped by the charge‐transfer band (CTB) of the host in near ultraviolet (NUV) spectral region and then produce strong and pure red emission at 615 nm originated from 5D0 → 7F2 electric dipole transition of Eu3+. The Commission Internationale de L’Eclairage (CIE) coordinates of Sr3Lu0.96(VO4)3:0.04Eu3+ are (x = 0.65, y = 0.35), which are very close to the red standard of National Television Standards Committee NTSC (0.67, 0.33). The fabricated warm white‐light‐emitting diodes (LED) demonstrate high color‐rendering index Ra as 93. The results imply the red‐emitting Sr3Lu(VO4)3:Eu3+ phosphors could be potentially utilized in the fields of solid‐state lighting.
Simultaneous self‐monitoring comparison of a supine algorithm‐equipped wrist nocturnal home blood pressure monitoring device with an upper arm device
Authors: Kario Kazuomi , Tomitani Naoko , Iwashita Chie , Shiga Tomoko , Kanegae Hiroshi 
Published: January 2021

AbstractA nocturnal home blood pressure (BP) monitoring device that measures nighttime BP levels accurately with less sleep disturbance is needed for the 24‐h management of hypertension. Here we conducted the first comparison study of simultaneous self‐monitoring by both a supine position algorithm‐equipped wrist nocturnal home BP monitoring device, the HEM‐9601T (NightView; Omron Healthcare) with a similar upper arm device, the HEM‐9700T (Omron Healthcare) in 50 hypertensive patients (mean age 68.9 ± 11.3 years). Both devices were worn on the same non‐dominant arm during sleep over two nights. The patients self‐measured their nighttime BP by starting nocturnal measurement mode just before going to bed. In total, 694 paired measurements were obtained during two nights (7.2 ± 1.5 measurements per night), and the mean differences (±SD) in systolic BP between the devices was 0.2 ± 10.2 mmHg (p = .563), with good agreement. In the comparison of nighttime BP indices, the difference in average SBP at 2:00, 3:00, and 4:00 AM and the average SBP of 1‐h interval measurements was −0.5 ± 5.5 mmHg (p = .337), with good agreement. The HEM‐9601T substantially reduced sleep disturbance compared to the upper arm‐type device. The newly developed HEM‐9601T (NightView) can thus accurately measure BP during sleep without reducing the wearer's sleep quality.
A review of iPhone and Android apps for cancer patients and survivors: assessing their quality, nutrition information and behaviour change techniques
Authors: Keaver Laura , Loftus Amy , Quinn Laoise 
Published: January 2021

AbstractBackgroundThe present study reviewed the quality, nutrition content and behaviour change techniques (BCTs) of apps aimed at those with cancer.MethodsThe Apple App Store and Androids’ Google Play were searched in March 2020. Apps were scored for accountability as per Silberg’s standards, quality as per the Mobile Application Rating Scale, and BCTs using the CALO‐RE Taxonomy. Nutrition content was summarised and a checklist developed from the European Society for Parenteral and Enteral Nutrition (ESPEN) cancer and nutrition guidelines and the World Cancer Research Fund (WCRF) guidelines for Cancer Survivors.ResultsTwelve apps were identified, mean (SD) accountability score was 2.7/8 (2.0) (range 0–6) and quality score was 2.9/5 (0.6) (range 1.7–3.7). Overall, 11 BCTs were used (range 0–8 per app). Nutrition content focussed on healthy eating and meeting energy needs. There was a lack of strategies for implementation and no indication of whether the advice was more suited for specific cancer types, stages or treatment. Limited reference was made to recommendations of ESPEN and the WCRF. A strong positive relationship between quality and number of BCTs was found (r = 0.805, n = 9, P = 0.01).ConclusionsLittle nutrition information is currently included on publicly available apps aimed at those with a cancer diagnosis.
Tracking the diffusion of industrial symbiosis scholarship using bibliometrics: Comparing across Web of Science, Scopus, and Google Scholar
Authors: Chertow Marian R. , Kanaoka Koichi S. , Park Jooyoung 
Published: January 2021

AbstractPrevious bibliometric analyses of industrial symbiosis (IS) research have focused on a limited body of literature owing to the scope of keyword searches or limitations of library databases. This study seeks to apply bibliometrics to explore broader, epistemological questions, particularly about the structure and geospatial development of IS as a sub‐field of industrial ecology. We also evaluate the benefits of using Google Scholar, in addition to the conventional databases Web of Science (WoS) and Scopus, for better understanding academic domains. By using WoS and Scopus, 805 articles on IS that met our criteria were identified, published in 212 journals from 1995 through 2018. On average, the cumulative number of relevant articles grew at an exponential rate of 18% per year—more than double the estimated growth of global scientific output. We observed the largest increases in articles that: (1) model the material and energy flows in IS clusters; (2) propose strategies and ideas for implementing symbiosis; and (3) evaluate the performance of IS networks. By the end of 2018, 54 countries were featured in IS articles retrieved from WoS and Scopus, with China as the single most studied country. The analysis of Google Scholar suggested that it can capture more IS articles than the conventional databases owing to its unique characteristic of searching the entire text of documents rather than solely their metadata as with WoS and Scopus. Google Scholar revealed IS discourse from additional countries and disciplines previously omitted, enabling a more acute view of its patterns of diffusion.
A balancing act: the role of pro‐ and anti‐stress peptides within the central amygdala in anxiety and alcohol use disorders
Authors: Walker Leigh C. 
Published: January 2021

AbstractThe central nucleus of the amygdala (CeA) is widely implicated as a structure that integrates both appetitive and aversive stimuli. While intrinsic CeA microcircuits primarily consist of GABAergic neurons that regulate amygdala output, a notable feature of the CeA is the heterogeneity of neuropeptides and neuropeptide/neuromodulator receptors that it expresses. There is growing interest in the role of the CeA in mediating psychopathologies, including stress and anxiety states and their interactions with alcohol use disorders. Within the CeA, neuropeptides and neuromodulators often exert pro‐ or anti‐ stress actions, which can influence anxiety and alcohol associated behaviours. In turn, alcohol use can cause adaptions within the CeA, which may render an individual more vulnerable to stress which is a major trigger of relapse to alcohol seeking. This review examines the neurocircuitry, neurochemical phenotypes and how pro‐ and anti‐stress peptide systems act within the CeA to regulate anxiety and alcohol seeking, focusing on preclinical observations from animal models. Furthermore, literature exploring the targeting of genetically defined populations or neuronal ensembles and the role of the CeA in mediating sex differences in stress x alcohol interactions are explored.image
Artemisinin inhibits TLR4 signaling by targeting co‐receptor MD2 in microglial BV‐2 cells and prevents lipopolysaccharide‐induced blood–brain barrier leakage in mice
Authors: Zhang Tianshu , Zhang Xiaozheng , Lin Cong , Wu Siru , Wang Fanfan , Wang Hongshuang , Wang Yibo , Peng Yinghua , Hutchinson Mark R. , Li Hongyuan , Wang Xiaohui 
Published: January 2021

AbstractArtemisinin and its derivatives have been the frontline drugs for treating malaria. In addition to the antiparasitic effect, accumulating evidence shows that artemisinins can alleviate neuroinflammatory responses in the central nervous system (CNS). However, the precise mechanisms underlying their anti‐neuroinflammatory effects are unclear. Herein we attempted to delineate the molecule target of artemisinin in microglia. In vitro protein intrinsic fluorescence titrations and saturation transfer difference (STD)‐NMR showed the direct binding of artemisinin to Toll‐like receptor TLR4 co‐receptor MD2. Cellular thermal shift assay (CETSA) showed that artemisinin binding increased MD2 stability, which implies that artemisinin directly binds to MD2 in the cellular context. Artemisinin bound MD2 showed much less collapse during the molecular dynamic simulations, which supports the increased stability of MD2 upon artemisinin binding. Flow cytometry analysis showed artemisinin inhibited LPS‐induced TLR4 dimerization and endocytosis in microglial BV‐2 cells. Therefore, artemisinin was found to inhibit the TLR4‐JNK signaling axis and block LPS‐induced pro‐inflammatory factors nitric oxide, IL‐1β and TNF‐α in BV‐2 cells. Furthermore, artemisinin restored LPS‐induced decrease of junction proteins ZO‐1, Occludin and Claudin‐5 in primary brain microvessel endothelial cells, and attenuated LPS‐induced blood–brain barrier disruption in mice as assessed by Evans blue. In all, this study unambiguously adds MD2 as a direct binding target of artemisinin in its anti‐neuroinflammatory function. The results also suggest that artemisinin could be repurposed as a potential therapeutic intervention for inflammatory CNS diseases.
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Dynamic subcellular localization and transcription activity of the SRF cofactor MKL2 in the striatum are regulated by MAPK
Authors: Ariza Anthony , Funahashi Yasuhiro , Kozawa Sachi , Omar Faruk Md. , Nagai Taku , Amano Mutsuki , Kaibuchi Kozo 
Published: January 2021

AbstractDopamine type 1 receptor (D1R) signaling activates protein kinase A (PKA), which then activates mitogen‐activated protein kinase (MAPK) through Rap1, in striatal medium spiny neurons (MSNs). MAPK plays a pivotal role in reward‐related behavior through the activation of certain transcription factors. How D1R signaling regulates behavior through transcription factors remains largely unknown. CREB‐binding protein (CBP) promotes transcription through hundreds of different transcription factors and is also important for reward‐related behavior. To identify transcription factors regulated by dopamine signaling in MSNs, we performed a phosphoproteomic analysis using affinity beads coated with CBP. We obtained approximately 40 novel candidate proteins in the striatum of the C57BL/6 mouse brain after cocaine administration. Among them, the megakaryoblastic leukemia‐2 (MKL2) protein, a transcriptional coactivator of serum response factor (SRF), was our focus. We found that the interaction between CBP and MKL2 was increased by cocaine administration. Additionally, MKL2, CBP and SRF formed a ternary complex in vivo. The C‐terminal domain of MKL2 interacted with CBP‐KIX and was phosphorylated by MAPK in COS7 cells. The activation of PKA‐MAPK signaling induced the nuclear localization of MKL2 and increased SRF‐dependent transcriptional activity in neurons. These results demonstrate that dopamine signaling regulates the interaction of MKL2 with CBP in a phosphorylation‐dependent manner and thereby controls SRF‐dependent gene expression.
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Cover Image for this issue: https://doi.org/10.1111/jnc.15067.
Phosphorylation of Collapsin Response Mediator Protein 1 (CRMP1) at Tyrosine 504 residue regulates Semaphorin 3A‐induced cortical dendritic growth
Authors: Kawashima Takeshi , Jitsuki‐Takahashi Aoi , Takizawa Kohtaro , Jitsuki Susumu , Takahashi Takuya , Ohshima Toshio , Goshima Yoshio , Nakamura Fumio 
Published: January 2021

AbstractCollapsin response mediator proteins (CRMPs) have been identified as mediating proteins of repulsive axon guidance cue Semaphorin‐3A (Sema3A). Phosphorylation of CRMPs plays a crucial role in the Sema3A signaling cascade. It has been shown that Fyn phosphorylates CRMP1 at Tyrosine 504 residue (Tyr504); however, the physiological role of this phosphorylation has not been examined. We found that CRMP1 was the most strongly phosphorylated by Fyn among the five members of CRMPs. We confirmed Tyr504 phosphorylation of CRMP1 by Fyn. Immunocytochemistry of mouse dorsal root ganglion (DRG) neurons showed that phosphotyrosine signal in the growth cones was transiently increased in the growth cones upon Sema3A stimulation. Tyr504‐phosphorylated CRMP1 also tended to increase after Sema3A simulation. Ectopic expression of a single amino acid mutant of CRMP1 replacing Tyr504 with phenylalanine (CRMP1‐Tyr504Phe) suppressed Sema3A‐induced growth cone collapse response in chick DRG neurons. CRMP1‐Tyr504Phe expression in mouse hippocampal neurons also suppressed Sema3A but not Sema3F‐induced growth cone collapse response. Immunohistochemistry showed that Tyr504‐phosphorylated CRMP1 was present in the cell bodies and in the dendritic processes of mouse cortical neurons. CRMP1‐Tyr504Phe suppressed Sema3A‐induced dendritic growth of primary cultured mouse cortical neurons as well as the dendritic development of cortical pyramidal neurons in vivo. Fyn±; Crmp1± double heterozygous mutant mice exhibited poor development of cortical layer V basal dendrites, which was the similar phenotype observed in Sema3a‐/‐, Fyn‐/‐, and Crmp1‐/‐ mice. These findings demonstrate that Tyr504 phosphorylation of CRMP1 by Fyn is an essential step of Sema3A‐regulated dendritic development of cortical pyramidal neurons. (247 words).
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Prospective randomized clinical study of a new topical formulation for face wrinkle reduction and dermal regeneration
Authors: Araco Antonino , Francesco Araco 
Published: January 2021

AbstractBackgroundA new topical formulation (TF) based on 3 main lifting components has been developed to reduce superficial facial wrinkles.ObjectivesDetermine the effectiveness of this new TF in reducing superficial face wrinkles and restructuring the dermal matrix.MethodsWomen, aged 30‐65 y.o. with moderate to severe crow's feet wrinkles were included. Exclusion criteria: men; younger than 30 or older than 65 years old; smokers. Patients received 15 IU of botulinum toxin on crow's feet and 2 creams. Fifty patients (Group 1) applied the TP (Product A) and 50 (Group 2) a placebo (Product B). Assessments were made by digital macro‐photography's, Antera 3D, and a patient satisfaction questionnaire.ResultsFrom April to June 2019, 100 women were enrolled in the study and were divided into two homogeneous groups. No major or minor side effects were reported. In group 1, wrinkles, texture, static and dynamic crow's feet wrinkles improved significantly at 3 and 6 months. Patients were very satisfied at 3 months and satisfied at 6 months. In group 2, wrinkles and texture improved significantly at 3 months but did not improve at 6 months. Static and dynamic crow's feet wrinkles improved significantly at 1 and 3 months but did not improve significantly at 6 months.ConclusionsOur prospective and randomized study has shown that the new TF is safe and effective in reducing superficial face wrinkles and producing dermal regeneration. It, therefore, prolongs the duration of the botulinum toxin. Further controlled study would be necessary to compare the new TF to neurotoxin treatment, or its action alone.
FINANCIALIZATION OF COMMODITIES BEFORE AND AFTER THE GREAT FINANCIAL CRISIS
Authors: Natoli Filippo 
Published: January 2021

AbstractMore than 12 years after the historical oil price spike, the financialization of commodities and the interaction among different types of commodity investors remain a hot topic. We review the early financialization literature and the main theoretical contributions to understand how market frictions can affect prices and liquidity. We introduce the debate on the de‐financialization and offer insights about the multifaceted role of commercial investors in derivatives markets. Last, we show how other research streams, such as the analysis of the shale industry and of other financial derivatives than futures, might complement the view on the financialization of commodities.
Sterile water; a novel and promising human experimental craniofacial muscle pain model
Authors: Louca Jounger Sofia , Svedenlöf Johanna , Elenius Reija , Källkrans Christoffer , Scheid Emil , Ernberg Malin , Christidis Nikolaos 
Published: January 2021

AbstractBackgroundThe aim of this study was to investigate if intramuscular injection of sterile water can be used as a human experimental pain model that resembles clinical craniofacial muscle pain and to analyse if the effects differ between sexes.MethodsThis randomised, double‐blind, placebo‐controlled cross‐over study included 30 healthy age‐matched women and men (23.6 ± 2.4 years). At three sessions, with at least one week of washout in between, 0.2 mL of either sterile water (test‐substance), hypertonic saline (58.5 mg/mL; active control) or isotonic saline (0.9 mg/mL; passive control) was randomly injected into the right masseter muscle. Pain intensity (VAS) was continuously assessed during 5 min whereafter pain duration (s) and pain area (au) were calculated; pressure pain thresholds (PPT;kPa) were recorded every 5 minutes during 30 minutes.ResultsSterile water evoked pain of similar intensity (74.5 ± 49.9) as hypertonic saline (74.0 ± 50.5); whereas, isotonic saline evoked low‐intensity pain (11.4 ± 23.4). The pain induced by sterile water and hypertonic saline had higher intensity (P < 0.001), longer duration (P < 0.001) and larger pain area (P < 0.001) than isotonic saline. There were no significant differences in any pain variable between sterile water and hypertonic saline. The PPT did not change significantly after any substance, except for in women 5 minutes after sterile water injection (P < 0.002). Pain duration was longer in the men for all substances (P < 0.006), while the pain area was larger in women after injection of hypertonic saline (P < 0.003).ConclusionThese results indicate that pain evoked by sterile water resembles clinical muscle pain and may offer a novel and simpler alternative to hypertonic saline injections.