bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time Perspective as A Common Transdiagnostic Factor of Mental Problems: A Systematic Review and Meta-Analysis Protocol
Authors: Yang Yi , Wong Siu Ching , Obsuth Ingrid , Murray Aja 
Published: March 2021

Abstract
BackgroundResearch into the transdiagnostic processes underlying multiple mental health problems is promising for making clinical practice and interventions more effective and resource-efficient. In this protocol, we describe a systematic review and meta-analysis that will explore time perspective, defined as an individual’s relative investment of attention on past, present, and future, as a possible transdiagnostic factor that may contribute to issues across wide-ranging domains of mental health. MethodsA systematic review and meta-analysis will be conducted to quantify the associations between mental health issue and specific dimensions of time perspective (past, present, future), respectively. The review will include quantitatively measured associations between time perspective and psychological problems published in a peer-reviewed journal from 1st January 1990 up until 1st March 2021, in the English language. Electronic searches will be conducted in Google Scholar, PubMed, MEDLINE, PsycINFO, and Web of Science, and EMBASE and supplemented by expert consultation and inspection of the reference lists of included papers. Screening, quality assessment and data extraction will be conducted by two reviewers independently, and potential conflicts will be resolved through discussion with a third reviewer. Random-effects meta-analysis will be conducted using the metafor package in R statistical software, and quality assessment will employ The Newcastle-Ottawa Quality Assessment Form for Cohort Studies and for Case-Control Studies. The Quality In Prognosis Studies (QUIPS) will be used to evaluate risk of bias. A narrative synthesis will additionally be used to summarize and interpret the results. DiscussionThe present review will provide the first systematic synthesis exploring the associations between time perspective defined as a multidimensional construct and a broad range of mental health issues. This will help evaluate the extent to which time perspective can be considered a key transdiagnostic factor in mental health and thus a key intervention target for the prevention and treatment of multiple mental health issues simultaneously. With a clearer view of the relations between time perspective and various mental health issues based on a robust synthesis, more focused, effective, and efficient interventions may be delivered. Systematic review registrationPROSPERO CRD42021228869
Gamma Aminobutyric Acid (GABA) and Salinity Impacts Physiological Response and Expression of Salinity-Related Genes in Strawberry cv. Aromas
Authors: Golnari Sahar , Vafaee Yavar , Nazari Farzad , Ghaderi Naser 
Published: March 2021

Abstract
Salinity is one of the most crucial abiotic stresses which is the consequence of increase in the concentration of NaCl ions influencing plant’s growth, development, and yield. Gama-butyric acid gamma (GABA) is a non-protein amino acid involved in various metabolic processes that accumulates in many plant species during stress conditions. The present study was aimed to evaluate the effect of GABA (0 and 25 mM) and salinity (3 and 5 dS/m) on physiological characteristics and expression pattern of some salinity-related genes in strawberry cv. Aromas under soilless culture condition 12, 24, and 36 h after treatments’ initiation. Based on the results, salinity increased the content of H2O2, MDA, and proline while it decreased the percentage of MSI and the activity of SOD and POD antioxidant enzymes. In contrast, the implementation of GABA not only decreased H2O2 and MDA content, and maintained MSI percentage, but also it improved the activity of antioxidant enzymes and the transcription level of DREB, cAPX, MnSOD, and GST genes. Under non-stress conditions, GABA acted as a mild stressor by imposing effects similar to abiotic stress which could help plants adapt under the adverse environmental conditions. We concluded that strawberry plants represented a higher salinity tolerance by enhancing both enzymatic and non-enzymatic antioxidant physiological protection mechanisms and also by increasing the transcription of salinity-related genes upon GABA application.
Influence of Sulfur and Light Intensity in Nutrient Removal, and Hydrogen and Ethanol Production by Optimized Biomass of Chlamydomonas Reinhardtii in Batch Anaerobic Photobioreactors
Authors: Vargas Sarah Regina , Zaiat Marcelo , Calijuri Maria do Carmo 
Published: March 2021

Abstract
Hydrogen is a renewable fuel that can be biologically produced by green algae in closed anaerobic photobioreactors with light and organic carbon as energy sources. This research aimed to investigate the influence of sulfur concentration and light intensity on hydrogen and ethanol production, as well as on nutrient removal by Chlamydomonas reinhardtii (CC425) in batch cultures. The strain was cultivated in two phases: in the first step, the cultures were maintained under aerobic conditions to obtain biomass; in the second step, the biomass was transferred to closed anaerobic photobioreactors for gas generation under continuous illumination. A factorial design was accomplished to optimize the biomass production in the first step, with light variation, pH, and glucose addition. Afterward, light intensity and sulfur concentration were varied to test hydrogen production in the second step. The best production occurred in photobioreactors without sulfur addition (average increase of 7 times in the production) and under higher light intensity the production was 37% higher than lower light (39.64 ± 2.44 µmol H2 L-1 h-1). There was an effect of sulfur concentration in the ethanol production and under higher light intensity the production was higher (203.20 ± 31.49 mg L-1). In addition, in general, under conditions with the presence of sulfur, there was greater removal of ammoniacal nitrogen (5.3%), phosphate (85.0%), COD (9.1%) and acetic acid (97.2%). This research demonstrates the efficient production of hydrogen and ethanol by C. reinhardtii and it shows that the process can be associated with nutrient removal.
Chronic Foot Pain and Foot Solutions in Adults from Different Professions: the I-Corps-National Science Foundation Foot Health Survey.
Authors: Mbue Ngozi D. , Wang Wanyi , Rosario Martin G. 
Published: March 2021

Abstract
Background: Chronic foot pain (CFP) is a major contributor to sick leave and early retirement among individuals in all professions, especially those whose jobs require prolonged standing, lifting and walking. Current treatment modalities are inadequate in managing CFP. Hence, there is a significant need for new treatment options to manage chronic foot pain. The objectives of this study are i) explore the current state of chronic foot pain; ii) investigate current solutions and treatment options; and iii) explore opportunities for future inventions to address chronic foot pain.Methods: Between April 2019 and September 2020, our team embarked on an I-Corps-National Science Foundation (NSF) programs in the United States to obtain information from stakeholders. Individualized, open-ended, mostly face-to-face interviews from nurses, athletes, construction and restaurant workers, among others were conducted.Results: Preliminary data (N=119) showed that current solutions and treatments for CFP were insufficient in managing moderate to acute pain (mostly pain scale 5 on a scale of 0-10). Those with ≥ 5 pain, changed shoes (63.3%), used shoe inserts, nursing clogs and painkillers (53.3%), and compression stockings (40%), with none reporting effectiveness. Fisher's exact tests were used to examine the relationships between regions (foot, heel and leg) and pain solutions. Regions (foot and heel) and shoe change were significantly related (p = 0.006) with participants using 5-7 pairs of shoes interchangeably, spending approximately $500-$700/year on new shoes. Female nurses 30-40 years experienced the highest foot pain than those younger. No significant differences in nursing and other professions with regards to CFP and solutions. Conclusions: The majority expressed interest in trying new products to relieve their chronic foot and heel pain. Risk factors for foot pain included prolonged standing, walking, and lifting heavy objects. Current solutions are inadequate for managing moderate to acute foot pain in those who stand for prolonged periods of time on their feet. Innovations are urgently needed to address CFP.
Severe congenital neutropenia due to G6PC3 deficiency. Case series of five patients and literature review
Authors: Velez-Tirado Natalia , Yamazaki-Nakashimada Marco Antonio , Valentín Enrique Lopez , Partida-Gaytan Armando , Scheffler-Mendoza Selma C , Semerena Genny M Chaia , Alvarez-Cardona Aristóteles , Gutiérrez Marcos Alejandro Suárez , Medina-Torres Edgar Alejandro , Capetillo Patricia Baeza , Hirschmugl Tatjana , Garncarz Wojciech , Espinosa-Padilla Sara Elva , Hernández Jesús Aguirre , Klein Christoph , Boztug Kaan , Reyes Saul Oswaldo Lugo 
Published: March 2021

Abstract
Glucose-6-phosphate catalytic subunit 3 (G6PC3) deficiency is characterized by severe congenital neutropenia with recurrent pyogenic infections, a prominent superficial venous pattern, and cardiovascular and urogenital malformations, caused by an alteration of glucose homeostasis, with increased endoplasmic reticulum stress and cell apoptosis. We describe five new cases from Mexico, and review 89 more patients reported in the past decade, to delineate the most frequent laboratory and genetic features, their treatment, and outcomes, and to expand the knowledge of syndromic and non-syndromic phenotypes in these patients.
Association Between Prehospital Airway Management Methods and Neurologic Outcome in Out-Of-Hospital Cardiac Arrest (OHCA) with Respiratory Cause.
Authors: Choi Yeongho , Kim Tae Han , Hong Ki Jeong , Song Kyoung Jun , Shin Sang Do 
Published: March 2021

Abstract
Purpose: Cardiac arrests are resulted by various aetiology including respiratory cause. Advanced airway placement is an important prehospital intervention for oxygenation and ventilation in respiratory cardiac arrest. We evaluated the association between of advanced airway method and neurologic outcome in arrest with respiratory cause.Method: Adult witnessed non-traumatic OHCAs treated by emergency medical service (EMS) providers in 2013-2017 were enrolled in a nationwide OHCA database. The association between airway management methods (endotracheal intubation (ETI), supraglottic airway (SGA) and bag valve mask (BVM)) and outcome were evaluated according to the presumed cause of cardiac arrest (cardiac, respiratory or others). The primary outcome was good neurological recovery at discharge. Multivariable logistic regression models with interaction analysis was conducted.Result: Of 40,443 eligible OHCA patients, the cause of arrest of 90.0%, 7.5%, and 2.4% of patients were categorized as cardiac, respiratory and others, respectively. There were no statistically significant differences in the effect of the advanced airway type on good neurologic recovery in the total population (aOR 0.96 (0.81-1.14) for ETI; 1.01 (95% CI 0.93-1.11) for BVM). However, ETI was associated with better neurologic recovery than SGA or BVM in OHCA in cardiac arrest with suspected respiratory cause (aOR 3.12 (95% CI 1.24-7.80) for ETI; 0.99 (95% CI 0.51-1.91) for BVM).Conclusion: Prehospital ETI was associated with good neurologic outcome when the cause of arrest was respiratory. ETI may be considered initially when a respiratory cause is suspected on the scene.
Isochoric specific heat in the Dual Model of Liquids and comparison with the Phonon theory of Liquid Thermodynamics
Authors: Peluso Fabio 
Published: March 2021

Abstract
We continue in this paper to illustrate the implications of the Dual Model of Liquids (DML) by deriving the expression for the isochoric specific heat as a function of the collective degrees of freedom available at a given temperature and comparing it with the analogous expression obtained in the Phonon Theory of Liquid Thermodynamics. The Dual Model of Liquids has been recently proposed as a model describing the dynamics of liquids at the mesoscopic level. Bringing together the early pictures of Brillouin and Frenkel and the recent experimental outcomes obtained by means of high energy scattering, liquids are considered in the DML as constituted by a population of wave packets, responsible for the propagation of elastic and thermal perturbations, and of dynamic aggregates of molecules, in continuous re-arrangement, diving in an ocean of amorphous, disordered liquid. The collective degrees of freedom contribute to the exchange of energy and momentum between the material particles and the lattice particles, which the liquids are supposed to be composed of in the DML.First, we show that the expression obtained for the specific heat in the DML is in line with the experimental results. Second, its comparison with that of the Phonon Theory of Liquid Thermodynamics allows getting interesting insights about the limiting values of the collective degrees of freedom and on that of the isobaric thermal expansion coefficient, two quantities that appear related to each other in this framework
Metabo-Endotypes of Asthma Reveal Clinically Important Differences in Lung Function: Discovery and validation in two TOPMed Cohorts
Authors: Kelly Rachel , Mendez Kevin , Huang Mengna , Hobbs Brian , Clish Clary , Gerszten Robert , Cho Michael , Wheelock Craig , McGeachie Michael , Chu Su , Celedon Juan , Weiss Scott , Lasky-Su Jessica 
Published: March 2021

Abstract
Current guidelines do not sufficiently capture the heterogeneous nature of asthma; a detailed molecular classification is needed. Metabolomics represents a novel and compelling approach to derive asthma endotypes, i.e., subtypes defined by functional/pathobiological mechanisms. In two cohorts of asthmatics, untargeted metabolomic profiling and Similarity Network Fusion was used to derive and validate five “metabo-endotypes” of asthma, which displayed significant differences in asthma-relevant phenotypes including pre-bronchodilator and post-bronchodilator forced expiratory volume/forced vital capacity (FEV1/FVC). The “most-severe” asthma metabo-endotype was defined by the lowest FEV1/FVC and characterized by altered levels of phospholipids and polyunsaturated fatty acids, suggesting dysregulation of pulmonary surfactant homeostasis. This was supported by genetic analyses as members of this endotype were more likely to carry variants in key pulmonary surfactant regulation genes including BMPR1B (meta-analyzed p=2.8x10-4) and BMP3 (meta-analyzed p=5.23x10-4). These findings suggest clinically meaningful endotypes can be derived and validated using metabolomic data. Interrogating the drivers of these metabo-endotypes can help understand their pathophysiology.
Biotransformation Mechanism of Inorganic Selenium into Selenomethionine and Selenocysteine by Saccharomyces Boulardii: In Silico Study
Authors: González-Salitre Lourdes , Román-Gutiérrez Alma Delia , Rodríguez-Serrano Gabriela Mariana , Jaimez-Ordaz Judith , Bautista-Ávila Mirandeli , González-Olivares Luis Guillermo 
Published: March 2021

Abstract
The biosynthesis of inorganic selenium into seleno amino acids has been studied in recent years. Thus, it has been reported that Saccharomyces cerevisiae bioaccumulates selenium from the metabolism of inorganic selenium. Based on the studies conducted, several authors have proposed a biotransformation metabolism of selenate into selenomethionine or selenocysteine. However, the pathway in different yeast is unknown. Therefore, and given the relevance of Saccharomyces boulardii as probiotic yeast, this study aims to propose the pathway used by S. boulardii to biosynthesize inorganic selenium into organic species. A comparative in silico study was performed for Saccharomyces boulardii ASM141397V1 with the genome-scale metabolic model of Saccharomyces cerevisiae S288C. Orthologous genes were identified using BLASTp of NCBI. In addition, a circular representation was done using CIRCOS software. The metabolic pathway for the assimilation of selenium was proposed based on the results obtained
Molecular Epidemiology of First Lumpy Skin Disease Outbreak in Odisha, India
Authors: Sethi Rajesh Kumar , Senapati Santosh Kumar , Selim Ahmed Magdy , Acharya Aditya Prasad , Mishra Chinmoy , Das Manoranjan , Biswal Shuvranshu Shekhar 
Published: March 2021

Abstract
Lumpy skin disease virus (LSDV) is the causative agent of lumpy skin disease (LSD) which is a member of Capripoxvirus. It is an economically critical transboundary disease affecting cattle. This study records the first LSD incidence in cattle of Ganjam district and analyses data from LSD outbreak in August 2020 on epidemiological and genetic characterization. Out of 452 animals clinically examined (59 farms), 63 animals were clinically affected with LSD, with a total morbidity rate of 13.93%. The morbidity rates in the villages (ten villages) varied from 5.55 to 21.62%. The multivariable logistic regression showed that grazing of animals (P=0.023; OR: 1.90; 95% CI: 1.09-3.32), and lactation and pregnancy status of animals (P=0.007; OR: 2.86; 95% CI: 1.32-6.17) were the potential risk factors for the occurrence of lumpy skin disease. Out of 53 clinically suspected animals collected from Ganjam district of Odisha, 18 samples (33.96%) were found positive by PCR for both P32 and F genes of capripox virus. Phylogenetic analysis of P32 gene of LSD (MW147486) showed 100% similarity with other isolates from India, Bangladesh, Egypt and Saudi Arabia. Additionally, phylogenetic analysis of F gene of LSD (MW147485) revealed a similarity of 97.99 %, 97.36%, and 96.60% with, Odisha India (MT074110), Beni Suif Egypt (MN694826) and Marsa Matrouh Egypt (MN699855), respectively.
The relationship between community violence and mental health symptoms in&nbsp;adolescents: Protocol for a systematic review
Authors: Miliauskas Claudia R , Faus Daniela Porto , Cruz Valeria , Vallaperde João Gabriel Rega do Nascimento , Junger Washington , Lopes Claudia Souza 
Published: March 2021

Abstract
Background: Mental health diseases are responsible for 16% of the global burden of disease in adolescents. Identifying the main determinants of these disorders in this age group can direct public and political efforts aimed at their prevention. Two previous meta-analyses showed a moderate and positive effect between exposure to community violence and mental health symptoms; however, there are still significant gaps to be addressed. Objectives: To evaluate whether adolescents’ exposure to a higher degree of community violence is associated with a higher risk of internalizing mental health symptoms and to investigate whether degrees of community violence events (victimization, witnesses and heard about) is associated with a higher risk of internalizing mental health outcomes (depression, anxiety and postraumatic stress disorder). Methods: A systematic review, research question and inclusion and exclusion criteria were developed according to the PEO format. The population consists of adolescents aged 10 to 24 years, the exposition involves individuals who were exposed to community violence, the comparison is adolescents who were not exposed or who were exposed to community violence to a smaller degree, and the outcome consists of internalizing mental health symptoms. Selection, extraction and quality assessment are being performed independently by two researchers. Results: A narrative synthesis will be presented. If possible, a meta-analysis will be performed with subgroup analyses of age, sex, degree of community violence and race. Publication bias will be assessed using funnel plots. This protocol has been registered in the International Prospective Register of Systematic Reviews (PROSPERO) - CRD 42019124740.
Sex differentiation and early sex identification in hatchery produced greater amberjack (Seriola dumerili) reared in sea cages
Authors: Papadaki Maria , Mandalakis Manolis , Anastasiou Thekla I. , Pouli Marina , Asderis Michalis , Katharios Pantelis , Papandroulakis Nikos , Mylonas Constantinos C. 
Published: March 2021

Abstract
The histological process of gonadal differentiation together with the endocrine changes of glucocorticoids and sex steroids was studied in hatchery produced greater amberjack (Seriola dumerili) from 101 until 408 days post-hatching. In the samplings, which were conducted every 50 days, no size dimorphism was observed between the sexes and sex ratio was 1:1, suggesting that there was no influence of early rearing in captivity on sex differentiation. Plasma concentrations of cortisol, cortisone, adrenosterone (Ad), androstenedione (Δ4), 11-ketotestosterone (11ΚΤ), testosterone (Τ), estradiol (Ε2), progesterone (P4) and 17,20β-dihydroxyprogesterone (DHP) were measured in males and females with the use of liquid chromatography tandem mass spectrometry (LC-MS/MS) to examine their role in the sex differentiation process. From the nine hormones, the only one that exhibited differences between the sexes was 11-KT. However, variations were observed in the mean values of cortisol, Ad, Δ4, 11-KT, T, P4 and DHP over time in one or both sexes, indicating their involvement in the sex differentiation process. Moreover, the 11-KT/E2 ratio was found to be a useful diagnostic biomarker for greater amberjack sex, from as early as 150 dph.
The effects of clonidine and yohimbine in the tail flick and hot plate tests in the naked mole rat (Heterocephalus glaber)
Authors: Mwobobia Royford , Titus Kanui , Klas Abelson 
Published: March 2021

Abstract
Objective: The naked mole rat (NMR) (Heterocephalus glaber) is increasingly considered an important biomedical research model for various conditions like hypoxic brain injury, cancer and nociception. This study was designed to investigate the effects of clonidine and yohimbine, an alpha-2 (α2) adrenoceptor agonist and antagonist respectively in the tail flick and hot plate tests. Results: A significant difference in tail flick latency was noted between saline control and 30µg/kg clonidine, which was reduced after administration of 30µg/kg yohimbine. A significant difference in hot plate latency was also noted between saline control and 30µg/kg clodinine during the periods 30, 45, 60, 75 and 90 minutes after administration, and between saline control and 10µg/kg clonidine during 30 minutes after administration. The hot plate latency by 30µg/kg clonidine was also reduced by 30µg/kg yohimbine during 30 minutes after administration. Since the tail-flick and hot plate tests mediate the effects at spinal and supraspinal levels respectively, the present study indicates the presence and involvement of noradrenergic receptors in thermal antinociception at spinal and supraspinal levels of the NMR, similar to what has been found in other mammals.