bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring the “weight” of human in vivo bio-inertia by legendary Galileo falling body experiments on a commercial 10m diving platform and gravitationally inversion of Newton's Three Laws of Motion into the Basic Laws of Evolution
Authors: Lai Yi Yu 
Published: October 2021

Abstract
Mutations of legendary Galileo falling bodies experiment with non-living objects in a non-isolated environment demonstrate that the recoverable internal motions of falling bodies can bind and polarize gravity over conventional Newtonian mass inertia. Bio quantum path experiments further interpret the binding mechanism and reveal the isolated logic restriction of Einstein’s equivalence principle. Mutations of the Cavendish experiment unveil 109 levels of gravitational differences between living and dead states. Mutations of the Galileo falling body experiments for living beings confirmed that such differences come from recoverable internal motion surface tension gravitational binding that can be calibrated as a measurable bio-inertia. We then calibrated the falling height difference for human in vivo bio-inertia on a commercial 10m diving platform and verified 98% of populations on Earth can safely be tested in this way with enough preparation training. In vivo lifetime gravitational binding curve that governs all biological parameters and reveals life evolutionary mechanisms becomes technologically feasible. These results, along with various facts, modulate the gravitational multi-surface tension region resonating model of in vivo bio quantum path inversion superposition. Photoelectric effect, PCR, GPCR, ancient CSF-ligament human Kungfu training systems, music harmonics, and board observations physically sustain this model. Newtonian Third Laws of motion are therefore evolved into Basic Laws of Evolution originates from surface tension non-unitary time inversion superposition that is different from the mathematical superposition in quantum mechanics; original memory negentropy is also disciplinarily integrated.
Omnidirectional Transfer for Quasilinear Lifelong Learning
Authors: Dey Jayanta , Vogelstein Joshua , Helm Hayden , Levine Will , Mehta Ronak , Geisa Ali , de Ven Gido van , Chang Emily , Gao Chenyu , Yang Weiwei , Tower Bryan , Larson Jonathan , White Christopher , Priebe Carey 
Published: October 2021

Abstract
In biological learning, data are used to improve performance not only on the current task, but also on previously encountered and as yet unencountered tasks. In contrast, classical machine learning starts from a blank slate, or tabula rasa, using data only for the single task at hand. While typical transfer learning algorithms can improve performance on future tasks, their performance on prior tasks degrades upon learning new tasks (called catastrophic forgetting). Many recent approaches for continual or lifelong learning have attempted to maintain performance given new tasks. But striving to avoid forgetting sets the goal unnecessarily low: the goal of lifelong learning, whether biological or artificial, should be to improve performance on all tasks (including past and future) with any new data. We propose omnidirectional transfer learning algorithms, which includes two special cases of interest: decision forests and deep networks. Our key insight is the development of the omni-voter layer, which ensembles representations learned independently on all tasks to jointly decide how to proceed on any given new data point, thereby improving performance on both past and future tasks. Our algorithms demonstrate omnidirectional transfer in a variety of simulated and real data scenarios, including tabular data, image data, spoken data, and adversarial tasks. Moreover, they do so with quasilinear space and time complexity.
Socio-demographic characteristics influencing knowledge, attitude and preventive practices of COVID-19 among Ghanaians: A cross-sectional study
Authors: Tawiah Philip Apraku , Arhin-Wiredu Kingsley , Oppong Kwabena , Torgbor Bernard Nii , Konadu Phenehance Effah , Abaka-Yawson Albert 
Published: October 2021

Abstract
Background

In recent times, the novel coronavirus disease, obviously, is one of the most challenging public health burden. Low-and-middle-income countries including Ghana have not been spared by the infection. Several measures are being undertaken by countries to control and prevent the future waves of the disease. Previous studies have established the importance of knowledge, attitude and practices towards an infection as remedy for controlling the spread of such infections. However, further studies are required to ascertain the socio-demographic characteristics influencing the knowledge, attitude and preventive measures of COVID-19.
Methods

This study investigated the socio-demographic characteristics influencing knowledge, attitude and practices towards COVID-19 infection among the Ghanaian population. A cross-sectional design was adopted to recruit 369 participants for the study by means of convenience and snowball sampling methods. With the use of an electronic semi-structured questionnaire and social media platforms, an online survey was conducted from March 26 – May 1, 2020. Descriptive statistics, independent t-test, chi-square test, one-way analysis of variance (ANOVA) and linear regression were used to analyze data.
Results

The average mean percentage of good knowledge, positive attitudes and good preventive practices regarding the novel coronavirus disease was 83.2%, 88.2% and 69.2%, correspondingly. In relation to occupation, there was significant difference (t = -2.984, p-value = 0.0030) in COVID-19 knowledge. Income level was significantly associated with attitudes towards COVID-19. Male gender (vs female, β = -1.276, p-value = < 0.00001), less than ¢500 income earners (vs above ¢1000, β = -0.845, p-value = 0.017) were associated with lower COVID-19 preventive practice score while being the 42–64 age category (vs 18–25-year group, β = 1.128, p-value = 0.028), health worker (vs non-health worker, β = 0.816, p-value = 0.001) and belonging to Ga ethnic group (vs Akan ethnic group, β = 0.89, p-value = 0.027) were associated with higher scores.
Conclusion

Although this study found higher knowledge and attitudes toward the novel coronavirus disease, it did not reflect in higher preventive practices towards the infection. In our fight against this infection in Ghana, COVID-19 preventive measure educational campaigns targeting male gender and low-income earners should be considered and implemented.
Berberine Induces NSCLC Apoptosis Via Activation of ROS/ASK1/JNK Pathway in Vitro and Vivo
Authors: chen qianqian , Hou Yaqin , Hao Bingjie , Ding Zhou , Xia Qing , Li Dan , Li Ming , Fan Lihong 
Published: October 2021

Abstract
BackgroundNon-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancers. Berberine (BBR), as an isoquinoline alkaloid, is commonly utilized in traditional Chinese medicine. Previous studies have proven that BBR possesses potential anti-tumor effect. However, the mechanism of on mitochondrial function in anti-NSCLC are still unknown.MethodsCell Counting Kit-8 (CCK-8), flow cytometry and western blotting were utilized to characterize the roles and relationships among BBR, ROS, ASK1, JNK, coxIV,caspase-3, cytochrome c ,bcl-2 and bax in NSCLC. Immunohistochemical (IHC) analysis was built to examine their expression in vivo.ResultsIn this study, we found that BBR potently suppressed NSCLC cells (A549 and PC9) growth by inducing apoptosis in a dose- and time-dependent manner. BBR induced apoptosis in NSCLC as evidenced by caspase-3 cleavage, cytochrome c release, and mitochondrial membrane depolarization. Furthermore, BBR induced ROS generation and ASK1 and JNK activation. To explore whether such apoptosis was linked to ROS production and ASK1 and JNK activation, we treated cells with a JNK inhibitor (SP600125), which significantly suppressed BBR-induced apoptosis. We further found that treating these cells with the anti-oxidant N-acetyl cysteine (NAC) was sufficient to both suppress ASK1 and JNK activation and to disrupt apoptotic induction.ConclusionsTogether, these data suggest that BBR induces NSCLC cells apoptosis via ROS-mediated ASK1/JNK and mitochondrial pathway activation.
Desflurane Does not Affect Post-Operative Short-Term Olfactory Memory of Patients Undergoing Laparoscopic Surgery Introduction: a prospective clinical study
Authors: Wang Zijun , Cao Ying , Su Jinhua , Gao Hong , Zhou Meiwu , Huang Jian , Chen Jie , Pan Jinzhe , Sun Changyu 
Published: October 2021

Abstract
Background: The purpose of our study was to evaluate the effect of 6% desflurane on short-term olfactory memory after laparoscopic surgery, and to investigate whether plasma concentrations of plasma S-100β protein, neuron specific enolase (NSE) and melatonin correlate with it.Methods: We collected medical data of patients who underwent laparoscopic surgery in the Second People's Hospital of Guiyang during May 2018 - February 2020. A total of 40 patients, who were aged 18-60 years old with American Society of Anesthesiologists (ASA) physical status I-II, were enrolled in the study. During the operation, the patients inhaled 6% desflurane to maintain the anesthesia. Patients were brought to the recovery room 45 minutes prior to the surgery (T0). And the patients were sent to the post-anesthesia care unit (PACU) after the surgery, if their Aldrete score was ≥ 9 points (T1), the CCCRC test was repeated to re-assess their olfactory memory. Venous blood samples (3 mL) were collected at T0 and T1, and the plasma was centrifuged at 3,000 rpm and then stored in a refrigerator at -20°C. Plasma S-100β protein, NSE, and melatonin levels were determined using ELISA.Results: There was no statistically significant difference in the odor identification score between T0 and T1 (P > 0.05). As compared with T0, the plasma concentrations of S-100β protein and NSE declined at T1. However, these differences were not statistically significant (P > 0.05). There were also no statistically significant changes in melatonin levels between T0 and T1 (P > 0.05）.Conclusions: This study found that undergoing general anesthesia with the inhaled anesthetic desflurane did not affect the short-term olfactory memory of patients undergoing laparoscopic surgery. This may be explained by the proposition that desflurane maintains plasma S-100β protein, NSE, and melatonin levels.Trial registration: Chinese Clinical Trial Registry (URL: http:// www.chictr.org.cn. Registry number: ChiCTR2100049441 ). Date of Registration: 2 August 2021.
Epidemiological Characteristics of Traumatic Spinal Cord Injury in Shaanxi, China
Authors: Yan Liang , Wang Dong , Du Jinpeng , Hao Dingjun , He Baorong , Zhao He , Ding Keyuan , Shi Haodong , Cao Yang , Qu Zechao , Huang Wangli , Feng Mingzhe 
Published: October 2021

Abstract
Study Design. A hospital-based retrospective epidemiological study.Summary of Background Data. TSCI is a highly disabling and deadly injury. Currently, there is little information regarding the epidemiological characteristics for TSCI in Shaanxi.Objective: To describe the demographic and epidemiological characteristics of patients with traumatic spinal cord injury (TSCI) in Shaanxi to help health-related institutions formulate corresponding measures.Methods. We retrospectively reviewed the medical records of the spine centers or orthopedic centers of the four cities in Shaanxi province according to the International Classification of Disease Version 10 (ICD-10) and diagnostic code of TSCI. Variables included gender, age, medical insurance, etiology, occupation, time of injury, level of injury, and severity of injury, multiple injury, treatment, and so on.Results: The study included the medical records of 694 patients with TSCI in 2018. The mean age of patients with TSCI was 48.4±14.9 years, and the male/female ratio was 3.45:1. The major causes of TSCI were high falls (40.2%) and low falls (26.7%). The most common injury site was the cervical spinal cord, accounting for 48.7%. The highest proportion of severity of injury was ASIA Grade D (37.8%). In addition, 74.6% of the patients had spinal fractures, the chest (38.0%) accounted for the highest proportion of all TSCI patients. Furthermore, 27.8% of the patients experienced clinical complications. 530 (76.4%) patients underwent surgery, 323 (46.5%) patients underwent inpatient rehabilitation.Conclusion: There are specific epidemiological characteristics of TSCI patients in Shaanxi, and preventive measures are suggested to be based on the characteristics of the different types of patients with TSCI and focused on high-risk groups.
Perceptions and Attitude of Women of Luderitz, Namibia on Pap Smear
Authors: Hausiku Lucia , Kouame Koffi , Aboua Yapo Guillaume 
Published: October 2021

Abstract
Background: Cervical cancer is one of the leading malignancies globally and has taken third place in Namibia amongst women aged 15-44 years. Infection with the Human Immunodeficiency Virus (HIV) has been proven to increase women’s susceptibility to developing cervical carcinoma. Sadly, Namibia carries a twin burden of HIV and cervical cancer. Namibians are aware of HIV/AIDS, but remain poorly informed about cervical cancer. Furthermore, among those who are aware of the disease, low utilisation of screening tests have been reported. Objective: The purpose was to explore perceptions and attitudes held by women about cervical cancer, reasons for low uptake of Pap smear testing amongst those who are aware of the malignancy as well as unearth motivation factors that has fuelled women to go for screening. Methodology: A descriptive, cross-sectional study was conducted using convenience sampling as a sampling technique. The survey instrument used was a self-administered questionnaire. It consisted of both closed and open ended questions. A total of 136 women were surveyed. Results and conclusion: The level of awareness for cervical cancer (92.6%) and Pap smear (93.4%) were high. Most were able to identify that pap smear test is used for screening for pre-cancerous lesions. However, knowledge about the impact of a HIV positive status along with co infection with HPV as the leading causes for progression of invasive cervical carcinoma was not well known. Knowledge about the other risk factors such as multiple sexual partners (39.7%), early sex debut (34.9%) and smoking was poorly demonstrated. This suggests that a high awareness level does not necessarily translate into having a good perception or understanding of a disease. A good attitude towards screening was observed although less than half of the study population reported ever having a test done.
An enhancement of instruments for solution of general transmission line equations with method of lines, impedance-/admittance and field transformation in combination with finite differences
Authors: Spiller Waldemar 
Published: October 2021

Abstract
The Method of Lines (MoL) in combination with impedance-/admittance and field transformation (IAFT) is used to analyze electromagnetic waves. The used cases are wave-guiding structures in microwave technology and optics. The core of the theory is the solution of generalized transmission line equations (GTL). In the case of complex structures, a combination with finite differences (FD) can be used. The quality of this solution essentially depends on the effectiveness of the used interpolation of the differences. The individual steps of the FD are permanently linked to the steps of the fully vectorial impedance-/admittance and/or field transformation, so standard libraries cannot be used. Two approaches based on the linear and quadratic interpolation were built into the impedance-/admittance and field transformation in the past. However, the degree of improvement due to one or another kind of interpolation depends on the concrete behavior of the solution sought. In the case of complex structures, choosing the appropriate type of interpolation should be an effective aid. In this paper, an extension of the family of built-in methods is proposed - with the possibility of being able to build any known numerical method from the class of one-step or multi-step methods into the GTL solution. These can be higher-order methods, including fast explicit methods, or particularly stable implicit methods. The transmission matrices for the impedance-/admittance and field transformation serve as the building site. To illustrate the procedure, some different methods are integrated into the GTL solution. The accuracy of the solutions is tested on selected complex structures and compared with each other and with existing solutions. It is shown that the optimal choice of method and the quality of the solution can depend on concrete structures. Keywords: Method of lines, generalized transmission line equations, impedance/admittance transformation, waveguide structures, finite differences, finite differences with second order accuracy.
Research on the Dynamic Evolution of Sponge City Construction Risk Based on System Dynamics
Authors: Zhao Hui , Li Zhijie , Zhang Jingqi 
Published: October 2021

Abstract
Following the research idea of "theoretical analysis -- mechanism analysis -- model simulation", the basic concept and basic theory of sponge city construction risk are firstly defined, and then the risk factors and internal mechanism of sponge city construction are analyzed by the grounded theory method. Finally, the system dynamics model is used for simulation. The dynamic development and key risk factors of each sub-risk system in the whole life cycle are analyzed, and the countermeasures to reduce the risk of sponge city construction are given.
Adaptive Convergence of Methylomes Reveals Epigenetic Drivers and Boosters of Repeated Relapses in Patient-matched Childhood Ependymomas and Identifies Targets for Anti-Recurrence Therapies
Authors: Zhao Sibo , Li Jia , Zhang Huiyuan , Qi Lin , Du Yuchen , Mari Kogiso , Braun Frank , Huang Yulun , Li Jianfan , Teo Wan-Yee , Lindsay Holly , Baxter Patricia , Su Jack , Adesina Adekunle , Xiao Sophie , Miklos Miklos , Genevini Paola , Veillard Anne-Clemence , Schvartzman Sol , Ding Shirong , Hua Yuanda , Stephan Clifford , Yang Jianhua , Goldman Stewart , Davies Peter , Chintagumpala Murali , Parsons Donald , Perlaky Laszlo , Xia Yun-Fei , Man Tsz-Kwong , Huang Yun , Song Yongcheng , Sun Deqiang , Li Xiao-Nan 
Published: October 2021

Abstract
Ependymoma (EPN) is the third most common brain tumor in children and frequently recurs. Here, we report an integrated longitudinal analysis of epigenetic, genetic and tumorigenic changes in 30 patient-matched repeated relapses obtained from 10 pediatric patients to understand the mechanism of recurrences. Genome-wide DNA methylation analysis revealed stable molecular subtypes and convergent epigenetic reprogramming during serial relapses of the 5 RELA and 5 PFA EPNs that paralleled with elevated patient-derived orthotopic xenograft (PDOX) (13/27) formation in the late relapses. Differentially methylated CpGs (DMCs) preexisted in the primary tumors and persisted in the relapses (driver DMCs) were detected, ranging from 51 hypo-methylated in RELA to 148 hyper-methylated DMCs in PFA tumors; while newly acquired DMCs sustained in all the relapses but was absent in the primary tumors (booster DMCs) ranged from 38- 323 hyper-methylated DMCs in RELA and PFA EPNs, respectively. Integrated analysis of these DMC associated DNA methylation regions (DMRs) and RNAseq in both patient and PDOX tumors identified a small fraction of the differentially expressed genes (4.6±4.4% in RELA and 4.5±1.1% in PFA) as regulated by driver DMRs (e.g., up-regulated CACNA1H, SLC12A7, RARA in RELA and HSPB8, GMPR, ITGB4 in PFA) and booster DMRs (including the sole upregulated PLEKHG1 in RELA and NOTCH, EPHA2, SUFU, FOXJ1 in PFA tumors). Most these genes were novel to EPN relapses. Seven DMCs in RELA and 22 in PFA tumors were also identified as potential relapse predictors. Finally, integrating DNA methylation with histone modification identified LSD1 as a relapse driver gene. Combined treatment of a novel inhibitor SYC-836 with radiation significantly prolonged survival times in two PDOX models of recurrent PFA. This high-resolution epigenetic and genetic roadmap of EPN relapse and our 13 new PDOX models should significantly facilitate biological and preclinical studies of pediatric EPN recurrences.
Prognostic Predictors For COVID-19 in Daily Clinical Practice in Japan: a Propensity Score-Matched Case-Control Study
Authors: Shinoda Masahiro , Ota Shinichiro , Yoshida Yuto , Hirouchi Takatomo , Shinada Kanako , Sato Takashi , Morikawa Miwa , Ishii Naoki , Shinkai Masaharu 
Published: October 2021

Abstract
Introduction: Blood tests and computed tomography (CT) findings at diagnosis are widely used in daily clinical practice and can offer useful prognostic factors for coronavirus disease 2019.Methods: We retrospectively evaluated 66 patients who underwent a blood test and CT between January 1 and May 31, 2020, and performed a propensity score-matched case-control study. Cases and controls were a severe respiratory failure group (non-rebreather mask, nasal high-flow, positive-pressure ventilation) and a non-severe respiratory failure group, matched at a ratio of 1:3 by propensity scores constructed by age, sex, and medical history. We compared groups for maximum body temperature up to diagnosis, laboratory findings, and CT findings in the matched cohort. Two-tailed P-values <0.05 were considered statistically significant.Results: Nine cases and 27 controls were included in the matched cohort. Significant differences were seen in maximum body temperature up to diagnosis (p=0.0043), the number of shaded lobes (p=0.0434), amount of ground-glass opacity (GGO) in the total lung field (p=0.0071), amounts of GGO (p=0.0001), and consolidation (p=0.0036) in the upper lung field, and pleural effusion (p=0.0117).Conclusions: Fever and CT findings (such as GGO and consolidation) may be prognostic indicators that can be easily measured at diagnosis.
RNAa-Mediated Epigenetic Attenuation of The Cell Senescence via Locus Specific Induction of Endogenous SIRT1
Authors: Mokhberian Neda , Sharifi Kazem , Soleimaninejadian Ehsan , Eftekhary Mohamad , Hashemi Seyed Mahmoud , Farhadi Shohreh , Miwa Satomi , Ghanbarian Hossein 
Published: October 2021

Abstract
SIRT1, a known regulator of cellular senescence, is a therapeutic target for age related disorders and its upregulation is a strategy to improve the cell therapeutic potentials of human mesenchymal stem cell (MSCs). Knockdown of natural antisense transcripts via small activating RNAs (RNAa) is an emerging approach for safe and locus specific gene regulation. We have recently identified a natural antisense transcript at human SIRT1 locus (SIRT1-NAT), the expression of which shows a negative correlation with that of SIRT1. To test the hypothetic upregulation of SIRT1 via knockdown of SIRT1-NAT, in this study we designed a single stranded oligonucleotide (SIRT1-antagoNAT) against the antisense transcript, transfection of which efficiently knocked down the SIRT1-NAT and induced SIRT1 transcription in human MSCs. In addition, activation of SIRT1 transfection via knockdown of SIRT1-NAT in human MSCs enhanced their proliferation and differentiation potentials, reduced senescence associated β-galactosidase activity and reversed the senescence associated molecular alterations. Our findings introduce an RNAa mediated approach for epigenetic induction of endogenous SIRT1 and the consequent attenuation of senescence. Further studies should evaluate the therapeutic potentials of this approach against various age related disorders.