bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemokine signaling is required for homeostatic and injury-induced neurogenesis in the olfactory epithelium
Authors: Senf Katja , Karius Julia , Stumm Ralf , Neuhaus Eva M. 
Published: May 2021

Abstract
The olfactory epithelium (OE) possesses unique lifelong neuroregenerative capacities and undergoes constitutive neurogenesis throughout mammalian lifespan. Two populations of stem cells, frequently dividing globose basal cells (GBCs) and quiescent horizontal basal cells (HBCs), readily replace olfactory neurons throughout lifetime. Although lineage commitment and neuronal differentiation of stem cells has already been described in terms of transcription factor expression, little is known about external factors balancing between differentiation and self-renewal. We show here that expression of the CXC-motif chemokine receptor 4 (CXCR4) distinguishes both types of stem cells. Extensive colocalization analysis revealed exclusive expression of CXCR4 in proliferating GBCs and their neuronal progenies. Moreover, only neuronal lineage cells were derived from CXCR4-CreER-tdTomato reporter mice in the OE. Furthermore, Cre-tdTomato mice specific for HBCs (Nestin+ and Cytokeratin14+) did not reduce CXCR4 expression when bred to mice bearing floxed CXCR4 alleles, and did not show labeling of the neuronal cells. CXCR4 and its ligand CXCL12 were markedly upregulated upon induction of GBC proliferation during injury-induced regeneration. in vivo overexpression of CXCL12 did downregulate CXCR4 levels, which results in reduced GBC maintenance and neuronal differentiation. We proved that these effects were caused by CXCR4 downregulation rather than over-activation by showing that the phenotypes of CXCL12-overexpressing mice were highly similar to the phenotypes of CXCR4 knockout mice. Our results demonstrate functional CXCR4 signaling in GBCs regulates cell cycle exit and neural differentiation. We propose that CXCR4/CXCL12 signaling is an essential regulator of olfactory neurogenesis and provide new insights into the dynamics of neurogenesis in the OE.
Advanced Chemical Methods for Stereoselective Sialylation and Their Applications in Sialoglycan Syntheses
Authors: Vibhute Amol M. , Komura Naoko , Tanaka Hide‐Nori , Imamura Akihiro , Ando Hiromune 
Published: May 2021

AbstractSialic acid is an important component of cell surface glycans, which are responsible for many vital body functions and should therefore be thoroughly studied to understand their biological roles and association with disorders. The difficulty of isolating large quantities of homogenous‐state sialoglycans from natural sources has inspired the development of the corresponding chemical synthesis methods affording acceptable purities, yields, and amounts. However, the related syntheses are challenging because of the difficulties in α‐glycosylation of sialic acid, which arises from its certain structural features such as the absence of a stereodirecting group at the C3 position and presence of carboxyl group at the anomeric position. Moreover, the structural complexities of sialoglycans with diverse numbers and locations of sialic acid on the glycan chains pose additional barriers. Thus, efficient α‐stereoselective routes to sialosides remain highly sought after, although various types of sialyl donors/acceptors have been developed for the straightforward synthesis of α‐sialosides. Herein, we review the latest progress in the α‐stereoselective synthesis of sialosides and their applications in the preparation of gangliosides and other sialoglycans.
Evolution of Earth‐Abundant 3 d‐Metallaelectro‐Catalyzed C−H Activation: From Chelation‐Assistance to C−H Functionalization without Directing Groups
Authors: Samanta Ramesh C. , Ackermann Lutz 
Published: May 2021

AbstractCatalyzed C−H functionalizations have emerged as a transformative platform for molecular syntheses. Despite of indisputable advances, oxidative C−H activations have been largely restricted to precious transition metals and stoichiometric amounts of chemical oxidants. In contrast, we herein discuss the potential of earth‐abundant, environmentally‐benign 3d transition metals for C−H activation, which has recently gained major momentum. Thus, a strategy for full resource economy has been established in our group, with green electricity as a renewable redox agent, giving valuable hydrogen as the sole byproduct under redox mediator‐free conditions. In this account, we detail our accomplishments in 3d metallaelectrocatalysis towards green syntheses until March 2021.
Derive Lovelock gravity from string theory in cosmological background
Authors: Wang Peng , Wu Houwen , Yang Haitang , Ying Shuxuan 
Published: May 2021

Abstract
It was proved more than three decades ago, that the first order α′ correction of string effective theory could be written as the Gauss-Bonnet term, which is the quadratic term of Lovelock gravity. In cosmological background, with an appropriate field redefinition, we reorganize the infinite α′ corrections of string effective action into a finite term expression for any specific dimension. This finite term expression matches Lovelock gravity exactly and thus fix the couplings of Lovelock gravity by the coefficients of string effective action. This result thus provides a strong support to string theory.
Interactions of ants with native and invasive lady beetles and the role of chemical cues in intraguild interference
Authors: Bucher Roman , Japke Laura M. , Ünlü Ayse Gül , Menzel Florian 
Published: May 2021

AbstractThe predator-predator naïveté hypothesis suggests that non-native predators benefit from being unknown to native predators, resulting in reduced intraguild interference with native predators. This novelty advantage should depend on the ability of native predators to recognize cues of non-native predators. Here, we compared ant aggression and lady beetle reaction in four native and the invasive lady beetle species Harmonia axyridis. In addition, we tested whether lady beetle cuticular hydrocarbons (CHCs) are involved in species recognition, which might explain naïveté if the invasive species has a specific CHC profile. To this end, we conducted behavioral assays confronting two native ant species with both living lady beetles and lady beetle elytra bearing or lacking CHCs of different lady beetle species. Finally, we characterized CHC profiles of the lady beetles using GC–MS. In general, the aggression of Lasius niger was more frequent than that of Myrmica rubra and L. niger aggression was more frequent towards most native lady beetle species compared to H. axyridis. The removal of CHCs from lady beetle elytra reduced aggression of both ant species. If CHCs of respective lady beetle species were added on cue-free elytra, natural strength of L. niger aggression could be restored. CHC analyses revealed a distinct cue composition for each lady beetle species. Our experiments demonstrate that the presence of chemical cues on the surface of lady beetles contribute to the strength of ant aggression against lady beetles. Reduced aggression of L. niger towards H. axyridis and reduced avoidance behavior in H. axyridis compared to the equally voracious C. septempunctata might improve the invasive lady beetle’s access to ant-tended aphids.
Do outcomes of psychiatric hospital treatment differ for migrants and non-migrants?
Authors: Anderson Kimberley , Giacco Domenico , Bird Victoria , Bauer Michael , Pfennig Andrea , Lasalvia Antonio , Ruggeri Mirella , Lorant Vincent , Nicaise Pablo , Moskalewicz Jacek , Welbel Marta , Priebe Stefan 
Published: May 2021

Abstract
Purpose
Providing effective treatment for immigrants is an increasing challenge for mental health services across Europe. Yet, little is known as to whether current practice is associated with different outcomes in migrant and non-migrant patients. We compared outcomes of inpatient psychiatric treatment for migrants and non-migrants in a sample from five European countries.

Methods
Patients with psychotic disorders, affective disorders or anxiety/somatisation disorders admitted to routine psychiatric inpatient treatment were assessed in hospitals in Belgium, Germany, Italy, Poland and the United Kingdom. Treatment outcomes were satisfaction with care during hospitalisation, length of stay, readmission to hospital (any and, specifically, involuntary re-hospitalisation), as well as untoward incidents in a 1-year follow-up period. Outcomes were compared between patients born inside (non-migrants) and outside (migrants) the country of treatment, through mixed regression models.

Results
Across all sites, 985 migrant patients and 6298 non-migrant patients were included. After accounting for the influence of confounding patient characteristics, migrants reported significantly lower treatment satisfaction, but there were no significant differences for length of stay and re-hospitalisations, in general and involuntary ones. Migrants had a lower rate of suicide attempts, but there was no significant difference in other types of untoward incidents in the year following the index admission.

Conclusion
The study suggests that migrants are less satisfied with their hospital treatment, there is no evidence that routine inpatient care as currently provided results overall in poorer objective outcomes for migrants than in non-migrant populations.
Secure Communication Channel Establishment: TLS 1.3 (over TCP Fast Open) versus QUIC
Authors: Chen Shan , Jero Samuel , Jagielski Matthew , Boldyreva Alexandra , Nita-Rotaru Cristina 
Published: May 2021

AbstractSecure channel establishment protocols such as Transport Layer Security (TLS) are some of the most important cryptographic protocols, enabling the encryption of Internet traffic. Reducing latency (the number of interactions between parties before encrypted data can be transmitted) in such protocols has become an important design goal to improve user experience. The most important protocols addressing this goal are TLS 1.3, the latest TLS version standardized in 2018 to replace the widely deployed TLS 1.2, and Quick UDP Internet Connections (QUIC), a secure transport protocol from Google that is implemented in the Chrome browser. There have been a number of formal security analyses for TLS 1.3 and QUIC, but their security, when layered with their underlying transport protocols, cannot be easily compared. Our work is the first to thoroughly compare the security and availability properties of these protocols. Toward this goal, we develop novel security models that permit “layered” security analysis. In addition to the standard goals of server authentication and data confidentiality and integrity, we consider the goals of IP spoofing prevention, key exchange packet integrity, secure channel header integrity, and reset authentication, which capture a range of practical threats not usually taken into account by existing security models that focus mainly on the cryptographic cores of the protocols. Equipped with our new models we provide a detailed comparison of three low-latency layered protocols: TLS 1.3 over TCP Fast Open (TFO), QUIC over UDP, and QUIC[TLS] (a new design for QUIC that uses TLS 1.3 key exchange) over UDP. In particular, we show that TFO’s cookie mechanism does provably achieve the security goal of IP spoofing prevention. Additionally, we find several new availability attacks that manipulate the early key exchange packets without being detected by the communicating parties. By including packet-level attacks in our analysis, our results shed light on how the reliability, flow control, and congestion control of the above layered protocols compare, in adversarial settings. We hope that our models will help protocol designers in their future protocol analyses and that our results will help practitioners better understand the advantages and limitations of secure channel establishment protocols.
Surface phenomena of gradient materials
Authors: Krawietz Arnold 
Published: May 2021

AbstractThe behavior of third gradient materials is analyzed. They possess stress tensor fields of second, third and fourth order. Starting from the principle of virtual power, we derive the admissible boundary conditions. Those on free surfaces can only be obtained by the application of the divergence theorem of surfaces. On the other hand, such an application to fictitious internal cuts makes no sense although it is usually practiced. We prove that some of the boundary conditions on a free surface may be interpreted as the equilibrium conditions of a shell. So a crust shell exists on such a surface and a beam exists where patches of the surface meet. On the other hand, no such shells or beams can be found with fictitious surfaces in the interior of a continuum. Our finding does not depend on any specific constitutive assumption.
International Conference on Advanced and Competitive Manufacturing Technologies milling tool wear prediction using unsupervised machine learning
Authors: Gittler Thomas , Glasder Magnus , Öztürk Elif , Lüthi Michel , Weiss Lukas , Wegener Konrad 
Published: May 2021

AbstractDegraded or defect machine components and consumables negatively impact manufacturing quality and productivity. Diagnosing and predicting the wear or degradation status of critical machine components or parts are therefore of general interest. To tackle this challenge, data-driven approaches based on supervised machine learning principles have demonstrated promising results. However, supervised learning models capable of degradation identification require large quantities of data. In practice, run-to-failure data in large amounts is usually not available and expensive to obtain. To overcome this issue, this study proposes an unsupervised learning approach for degradation prognostics of machine tool components and consumables. It uses time series of multi-sensor signal data, which are transformed into a feature representation. The features consist of various characterizations of the time series, allowing to make different signal measurements comparable, and cluster them according to their feature values. The herewith obtained density-based clustering model is used to diagnose and predict the degradation states of components and parts in unknown conditions. The novelty in the proposed approach lies within the identification of continuous component and part degradation states based on unsupervised learning principles. The proposal is verified and demonstrated on an exemplary data set containing a small sample of run-to-failure multi-sensor signals of milling inserts and their corresponding wear state. By the application of the proposed procedure on the exemplary data set, we demonstrate that an unsupervised clustering approach is capable of separating wear data such that meaningful and accurate estimations of the part condition are possible. The advantages are its ability to cope with scarce data sets, its limited engineering and hyperparameter tuning effort, and its straightforward implementation to a multitude of degradation and wear diagnostics scenarios.
The electrophysiological effects of cannabidiol on action potentials and transmembrane potassium currents in rabbit and dog cardiac ventricular preparations
Authors: Topal Leila , Naveed Muhammad , Orvos Péter , Pászti Bence , Prorok János , Bajtel Ákos , Kiss Tivadar , Csupor-Löffler Boglárka , Csupor Dezső , Baczkó István , Varró András , Virág László , Jost Norbert 
Published: May 2021

AbstractCannabis use is associated with known cardiovascular side effects such as cardiac arrhythmias or even sudden cardiac death. The mechanisms behind these adverse effects are unknown. The aim of the present work was to study the cellular cardiac electrophysiological effects of cannabidiol (CBD) on action potentials and several transmembrane potassium currents, such as the rapid (IKr) and slow (IKs) delayed rectifier, the transient outward (Ito) and inward rectifier (IK1) potassium currents in rabbit and dog cardiac preparations. CBD increased action potential duration (APD) significantly in both rabbit (from 211.7 ± 11.2. to 224.6 ± 11.4 ms, n = 8) and dog (from 215.2 ± 9.0 to 231.7 ± 4.7 ms, n = 6) ventricular papillary muscle at 5 µM concentration. CBD decreased IKr, IKs and Ito (only in dog) significantly with corresponding estimated EC50 values of 4.9, 3.1 and 5 µM, respectively, without changing IK1. Although the EC50 value of CBD was found to be higher than literary Cmax values after CBD smoking and oral intake, our results raise the possibility that potassium channel inhibition by lengthening cardiac repolarization might have a role in the possible proarrhythmic side effects of cannabinoids in situations where CBD metabolism and/or the repolarization reserve is impaired.
Geometric Rényi Divergence and its Applications in Quantum Channel Capacities
Authors: Fang Kun , Fawzi Hamza 
Published: May 2021

AbstractHaving a distance measure between quantum states satisfying the right properties is of fundamental importance in all areas of quantum information. In this work, we present a systematic study of the geometric Rényi divergence (GRD), also known as the maximal Rényi divergence, from the point of view of quantum information theory. We show that this divergence, together with its extension to channels, has many appealing structural properties, which are not satisfied by other quantum Rényi divergences. For example we prove a chain rule inequality that immediately implies the “amortization collapse” for the geometric Rényi divergence, addressing an open question by Berta et al. [Letters in Mathematical Physics 110:2277–2336, 2020, Equation (55)] in the area of quantum channel discrimination. As applications, we explore various channel capacity problems and construct new channel information measures based on the geometric Rényi divergence, sharpening the previously best-known bounds based on the max-relative entropy while still keeping the new bounds single-letter and efficiently computable. A plethora of examples are investigated and the improvements are evident for almost all cases.
The signing body: extensive sign language practice shapes the size of hands and face
Authors: Mora Laura , Sedda Anna , Esteban Teresa , Cocchini Gianna 
Published: May 2021

AbstractThe representation of the metrics of the hands is distorted, but is susceptible to malleability due to expert dexterity (magicians) and long-term tool use (baseball players). However, it remains unclear whether modulation leads to a stable representation of the hand that is adopted in every circumstance, or whether the modulation is closely linked to the spatial context where the expertise occurs. To this aim, a group of 10 experienced Sign Language (SL) interpreters were recruited to study the selective influence of expertise and space localisation in the metric representation of hands. Experiment 1 explored differences in hands’ size representation between the SL interpreters and 10 age-matched controls in near-reaching (Condition 1) and far-reaching space (Condition 2), using the localisation task. SL interpreters presented reduced hand size in near-reaching condition, with characteristic underestimation of finger lengths, and reduced overestimation of hands and wrists widths in comparison with controls. This difference was lost in far-reaching space, confirming the effect of expertise on hand representations is closely linked to the spatial context where an action is performed. As SL interpreters are also experts in the use of their face with communication purposes, the effects of expertise in the metrics of the face were also studied (Experiment 2). SL interpreters were more accurate than controls, with overall reduction of width overestimation. Overall, expertise modifies the representation of relevant body parts in a specific and context-dependent manner. Hence, different representations of the same body part can coexist simultaneously.
On the Boussinesq Equations with Non-monotone Temperature Profiles
Authors: Zillinger Christian 
Published: May 2021

AbstractIn this article, we consider the asymptotic stability of the two-dimensional Boussinesq equations with partial dissipation near a combination of Couette flow and temperature profilesT(y). As a first main result, we show that if$$T'$$T′is of size at most$$\nu ^{1/3}$$ν1/3in a suitable norm, then the linearized Boussinesq equations with only vertical dissipation of the velocity but not of the temperature are stable. Thus, mixing enhanced dissipation can suppress Rayleigh–Bénard instability in this linearized case. We further show that these results extend to the (forced) nonlinear equations with vertical dissipation in both temperature and velocity.
The use of a non-biological, bridging, antiprotrusio cage in complex revision hip arthroplasty and periacetabular reconstructive oncologic surgery. Is still today a valid option?: A mid/long-term survival and complications’ analysis
Authors: Innocenti Matteo , Muratori Francesco , Mazzei Giacomo , Guido Davide , Frenos Filippo , Lucenteforte Ersilia , Capanna Rodolfo , Campanacci Domenico Andrea 
Published: May 2021

AbstractIntroductionBurch–Schneider-like antiprotrusio cages (B-SlAC) still remain helpful implants to bridge severe periacetabular bone losses. The purpose of this study was to evaluate outcomes and estimate both cages’ failures and complication risks in a series of B-SlAC implanted in revision of failed total hip arthroplasties (THA) or after resection of periacetabular primary or secondary bone malignancies. Risk factors enhancing the chance of dislocations and infections were checked.Materials and methodsWe evaluated 73 patients who received a B-SlAC from January 2008 to January 2018. Group A, 40 oncological cases (22 primary tumors; 18 metastases); Group B, 33 failed THAs. We compared both Kaplan–Meier estimates of risk of failure and complication with the cumulative incidence function, taking account the competing risk of death. Cox proportional hazards model was utilized to identify possible predictors of instability and infection. Harris hip score HHS was used to record clinical outcomes.ResultsMedium follow-up was 80 months (24–137). Average final HHS was 61 (28–92), with no differences within the two groups (p > 0.05). The probabilities of failure and complications were 57% and 26%, respectively, lower in the oncologic group than in the rTHA group (p =0 .176; risk 0.43) (p = 0.52; risk 0.74). Extended ileo-femoral approach and proximal femur replacement (p =0.02, risk ratio = 3.2;p = 0.04, rr = 2.1) were two significant independent predictors for dislocations, while belonging to group B (p = 0.04, rr = 2.6) was predictable for infections.ConclusionBurch–Schneider-like antiprotrusio cages are a classical non-biological acetabular reconstruction method that surgeons should bear in mind when facing gross periacetabular bone losses, independently of their cause. However, dislocation and infection rates are high. Whenever possible, we suggest preserving the proximal femur in revision THA, and to use a less-invasive postero-lateral approach to reduce dislocation rates in non-oncologic cases.
Vitali’s generalized absolute differential calculus
Authors: Cogliati Alberto 
Published: May 2021

AbstractThe paper provides an analysis of Giuseppe Vitali’s contributions to differential geometry over the period 1923–1932. In particular, Vitali’s ambitious project of elaborating a generalized differential calculus regarded as an extension of Ricci-Curbastro tensor calculus is discussed in some detail. Special attention is paid to describing the origin of Vitali’s calculus within the context of Ernesto Pascal’s theory of forms and to providing an analysis of the process leading to a fully general notion of covariant derivative. Finally, the reception of Vitali’s theory is discussed in light of Enea Bortolotti and Enrico Bompiani’s subsequent works.