bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling restoration of gefitinib efficacy by co‐administration of MET inhibitors in an EGFR inhibitor‐resistant NSCLC xenograft model: A tumor‐in‐host DEB‐based approach
Authors: Tosca Elena M. , Gauderat Glenn , Fouliard Sylvain , Burbridge Mike , Chenel Marylore , Magni Paolo 
Published: October 2021

AbstractMET receptor tyrosine kinase inhibitors (TKIs) can restore sensitivity to gefitinib, a TKI targeting epidermal growth factor receptor (EGFR), and promote apoptosis in non‐small cell lung cancer (NSCLC) models resistant to gefitinib treatment in vitro and in vivo. Several novel MET inhibitors are currently under study in different phases of development. In this work, a novel tumor‐in‐host modeling approach, based on the Dynamic Energy Budget (DEB) theory, was proposed and successfully applied to the context of poly‐targeted combination therapies. The population DEB‐based tumor growth inhibition (TGI) model well‐described the effect of gefitinib and of two MET inhibitors, capmatinib and S49076, on both tumor growth and host body weight when administered alone or in combination in an NSCLC mice model involving the gefitinib‐resistant tumor line HCC827ER1. The introduction of a synergistic effect in the combination DEB‐TGI model allowed to capture gefitinib anticancer activity enhanced by the co‐administered MET inhibitor, providing also a quantitative evaluation of the synergistic drug interaction. The model‐based comparison of the two MET inhibitors highlighted that S49076 exhibited a greater anticancer effect as well as a greater ability in restoring sensitivity to gefitinib than the competitor capmatinib. In summary, the DEB‐based tumor‐in‐host framework proposed here can be applied to routine combination xenograft experiments, providing an assessment of drug interactions and contributing to rank investigated compounds and to select the optimal combinations, based on both tumor and host body weight dynamics. Thus, the combination tumor‐in‐host DEB‐TGI model can be considered a useful tool in the preclinical development and a significant advance toward better characterization of combination therapies.
Antidepressant‐like effect of rosmarinic acid during LPS‐induced neuroinflammatory model: The potential role of cannabinoid receptors/PPAR‐γ signaling pathway
Authors: Lataliza Alexandre Augusto Barros , de Assis Pollyana Mendonça , da Rocha Laurindo Larissa , Gonçalves Elaine Cristina Dalazen , Raposo Nádia Rezende Barbosa , Dutra Rafael Cypriano 
Published: October 2021

Rosmarinic acid (RA), an ester of caffeic acid and 3, 4‐dihydroxyphenyllactic acid, has anti‐inflammatory and neuroprotective activities. Herein, this study investigated in silico the drug‐likeness and the potential molecular targets to RA. Moreover, it tested the antidepressant‐like potential of RA in the lipopolysaccharide (LPS)‐induced depression model. RA (MW = 360.31 g/mol) meets the criteria of both Lipinski's rule of five and the Ghose filter. It also attends to relevant pharmacokinetic parameters. Target prediction analysis identified RA's potential targets and biological activities, including the peroxisome proliferator‐activated receptor (PPAR) and the cannabinoid receptors CB1 and CB2. In vivo, RA's acute, repetitive, and therapeutic administration showed antidepressant‐like effect since it significantly reduced the immobility time in the tail suspension test and increased grooming time in the splash test. Further, the pretreatment with antagonists of CB1, CB2, and PPAR‐γ receptors significantly blocked the antidepressant‐like effect of RA. Altogether, our findings suggest that cannabinoid receptors/PPAR‐γ signaling pathways are involved with the antidepressant‐like effect of RA. Moreover, this molecule meets important physicochemical and pharmacokinetic parameters that favor its bioavailability. RA constitutes a promising, innovative, and safe molecule for the pharmacotherapy of major depressive disorder.
Post‐coronavirus disease 2019 organizing pneumonia confirmed pathologically by video‐assisted thoracoscopic surgery
Authors: Sugino Keishi , Ono Hirotaka , Haraguchi Shuji , Igarashi Seiji , Hebisawa Akira , Tsuboi Eiyasu 
Published: October 2021

AbstractCoronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2, has become a global pandemic. Many survivors of serious COVID‐19 pneumonia have long‐term residual pulmonary disease. However, there is little documentation of the histopathological characteristics of lung sequelae post‐COVID‐19 and effective treatments. We present two Japanese cases of lung sequelae post‐COVID‐19. The patients were histopathologically diagnosed with organizing pneumonia (OP) or OP with fibrosis and no diffuse alveolar damage on video‐assisted thoracoscopic surgery. Case 1, who had been diagnosed with OP, was successfully treated with corticosteroid and other immunosuppressive agents over a 6‐month period. Although case 2, who had been diagnosed with OP with fibrosis, had a partial and unsatisfactory response to immunosuppressive agents, the patient responded to antifibrotic treatment including nintedanib.
Characterizing vegetated rivers using novel unmanned aerial vehicle‐borne topo‐bathymetric green lidar: Seasonal applications and challenges
Authors: Islam Md. Touhidul , Yoshida Keisuke , Nishiyama Satoshi , Sakai Koichi , Tsuda Tomoyuki 
Published: October 2021

AbstractTopo‐bathymetric surveys of stream channels and floodplains, along with their vegetation distributions, are difficult and expensive to quantify, but they are crucially important for balanced river management, addressing issues such as flood risk and ecosystem management. This study was conducted to demonstrate seasonal accuracy for the first time, appraising results of a novel cost‐effective unmanned aerial vehicle (UAV)‐borne topo‐bathymetric light detection and ranging (lidar) used to examine the vegetated and gravel‐bedded lower Asahi River, Japan. Compared with autumn, the winter findings were almost identical to those from ground‐truth observations with outperformed accuracy ranging from around 2 to 12 cm of root‐mean‐square‐error values. The results were compatible with the corresponding high‐resolution aerial image. During winter, the three‐dimensional laser point clouds identified details of the submerged artificial infrastructure of the river and the continuous topography of underwater (shallower than or equal to 2.08 m depth) and overland areas. In comparison, the autumn's bathymetric performance was limited to a depth of 1.20 m and turbidity of 5.50 NTU because measurements were conducted after a flooding event. Furthermore, this study applied novel approaches for accurate land cover mapping and vegetation height assessment, which can be readily applied in future riverine vegetation appraisal studies. In conclusion, because the point cloud data can be useful as input and validation data in hydrodynamic‐numerical models and riparian vegetation identification, lidar can be regarded as a technique to inform the management of clear‐flowing and shallow streams with vegetated floodplains.
Layered Double Hydroxide Hollowcages with Adjustable Layer Spacing for High Performance Hybrid Supercapacitor
Authors: Ma Jiamin , Xia Jiale , Liang Zhong , Chen Xiaoyun , Du Yaping , Yan Chun‐Hua 
Published: October 2021

AbstractLayered double hydroxides (LDHs) have been considered as promising electrodes for supercapacitors due to their adjustable composition, designable function and superior high theoretic capacity. However, their experimental specific capacity is significantly lower than the theoretical value due to their small interlayer spacing. Therefore, obtaining large interlayer spacing through the intercalation of large‐sized anions is an important means to improve capacity performance. Herein, a metal organic framework derived cobalt‐nickel layered double hydroxide hollowcage intercalated with different concentrations of 1,4‐benzenedicarboxylic acid (H2BDC) through in‐situ cationic etching and organic ligand intercalation method is designed and fabricated. The superior specific capacity and excellent rate performance are benefit from the large specific surface area of the hollow structure and increasing interlayer spacing of LDH after H2BDC intercalation. The sample with the largest layer spacing displays a maximum specific capacity of 229 mA h g−1 at 1 A g−1. In addition, the hybrid supercapacitor assembled from the sample with the largest layer spacing and active carbon electrode has a maximum specific capacity of 158 mA h g−1 at 1 A g−1; the energy density is as high as 126.4 W h kg−1 at 800 W kg−1 and good cycle stability.
Alkali Metal Chloride‐Doped Water‐Based TiO2 for Efficient and Stable Planar Perovskite Photovoltaics Exceeding 23% Efficiency
Authors: Gao Feng , Luo Chao , Wang Xianjin , Zhao Qing 
Published: October 2021

AbstractTiO2 is one of the most broadly employed electron transport materials in n‐i‐p structure perovskite solar cells (PSCs). Low‐temperature non‐hydrolyzed sol–gel method is developed to prepare TiO2 in order to simplify the fabrication process and match with the planar structure PSCs. Conventional low‐temperature TiO2 film using organic solvents as dispersants makes direct doping challenging due to limited solubility. Here, a newly developed water‐based TiO2 solution is directly doped with different alkali chlorides, resulting in better conductivity, compatible energy level matching, and enhanced charge extraction in terms of electron transport layer (ETL) for PSCs. As a result, a power conversion efficiency of 23.15% is achieved based on NaCl‐doped TiO2 with competitive storage stability and light stability. The water‐based TiO2 ETL for more general doping of various solutes opens up a new avenue for environmental‐friendly manufacturing superior ETL toward high‐efficiency and stable perovskite photovoltaic devices.
Multiscale Observations of Inhomogeneous Bilayer SEI Film on a Conversion‐Alloying SnO2 Anode
Authors: Lan Xuexia , Cui Jie , Xiong Xingyu , He Jiayi , Yu Hechuan , Hu Renzong 
Published: October 2021

AbstractSnO2, storing Li through conversion and alloying reactions, has been regarded as one of the most typical anode materials and has been widely studied for both mechanism exploring and performance tuning. However, the structure of the solid electrolyte interphase (SEI) formed on the SnO2 electrode and its evolution process are rarely focused and still poorly understood. Herein, time of flight secondary ion mass spectrometry is used to observe the bilayer hybrid structure of SEI formed on a SnO2 film. Multiscale observations reveal the SEI accumulation after alloying reactions and distinct dissolving of the organic layer at potentials above de‐conversion reactions, which results in the inorganic layer being directly exposed to the electrolyte and thus becoming thick and inhomogeneous. The broken and thick SEI causes rapid capacity decay and low Coulombic efficiencies (CEs) of 97.5%. Accordingly, it is demonstrated that, as the SnO2 is precoated with LiF or Li2CO3, a robust and thin SEI layer is induced to form and is stabilized in the continuous cycles, resulting in enhanced cycling stability and promoted CEs to 99.5%. This work adds new insights to the SEI evolution mechanisms on SnO2‐based anodes and suggests an effective strategy to create high performance metal oxide anode for Li‐ion batteries.
Transition Metal/Lewis Acid Catalyzed Reactions of Zerumbone for Diverse Molecular Motifs
Authors: Biji Mohanan , Prabha Bernard , Lankalapalli Ravi S. , Radhakrishnan Kokkuvayil Vasu 
Published: October 2021

AbstractZerumbone is a naturally occurring humulene type sesquiterpene, isolated from the rhizomes of Zingiber zerumbet (L.) Smith with excellent therapeutic potential and is recognized as a valuable synthon for the construction of diverse array of natural product motifs. In this review, we intended to highlight our achievements in utilizing abundant natural product zerumbone and its derivatives for the development of pharmacologically relevant molecular scaffolds. We provided an account of the transition‐metal catalyzed 1,4‐conjugate addition reactions of zerumbone and its derivatives along with palladium‐catalyzed cross‐couplings, transition metal‐based Lewis acid promoted interrupted Nazarov cyclisation reaction with substituted indoles and transannular cyclizations, photo‐induced transformations of zerumbone and its epoxide.
Experimental investigation of lateral resisting elements for the wood polyvinyl chloride composite log‐house under in‐plane lateral loads
Authors: Eakintumas Warawit , Pulngern Tawich , Rosarpitak Vichai , Sombatsompop Narongrit 
Published: October 2021

AbstractThis study applied WPVC composite materials as log elements and investigated the lateral load resistance capability using two first log–foundation connections (LS‐SST and LF‐AB) and two corner joints (CJ‐SN and CJ‐SHL) subjected to monotonic and cyclic loads via an experimental approach. The obtained results indicated that the load resisting behavior of the connections was different, although the load bearing area of the connections was similar. The LF‐SST connections experienced a brittle failure, while LF‐AB showed a ductile failure. The premature failure occurred at the hollow web section of orthogonal log elements for both corner joints. The presence of a metal fastener directly affected the lateral load resisting behavior of the connection, especially under cyclic loading. The equivalent energy elastic plastic (EEEP) and hysteretic parameters were determined, indicating that LF‐AB provided 1.8 times of ductility ratio and 35.4% of hysteretic energy higher than LF‐SST, and that CJ‐SHL had 3.1 and 2.8 times of monotonic and cyclic stiffnesses higher than CJ‐SN. In comparing the experimental results with timber log elements, the hollow section of the WPVC composite log element had a negligible effect on load resisting behavior; however, it significantly affected the load resisting capacity, stiffness, damping, and premature failure. The experimental data and the proposed parameters will be useful for the further design of WPVC composite log houses.
Psychosocial and Patient Support Services in Comprehensive Cancer Centers
Authors: Chakraborty Rajshekhar , Majhail Navneet S. , Abraham Jame 
Published: October 2021

AbstractPatient support and psychosocial services are an important aspect of cancer care. Comprehensive cancer centers need to provide a spectrum of these services to provide high-quality and holistic care to cancer patients. Provision of these services begins from the time of diagnosis, continues through cancer treatment, and then subsequently transitions to survivorship or end-of-life phase. Examples of these services include psychological assessment and management, patient navigation, care coordination, genetic counseling, and complementary medicine. Survivorship care is an important aspect of patients’ experience during their cancer journey and beyond. This chapter discusses key psychosocial and supportive care services that are recommended for cancer centers that strive to provide comprehensive cancer care to their patients.
Transplantation and Cellular Therapy
Authors: Majhail Navneet S. , De Lima Marcos 
Published: October 2021

AbstractComprehensive cancer services include provision of care to patients with advanced hematologic malignancies, among whom some patients are candidates for hematopoietic cell transplantation (HCT). HCT is a complex and resource-intense medical procedure and optimal transplant outcomes require a high-functioning, multidisciplinary, and cohesive team. The presence of a successful HCT program reflects the commitment from a cancer center to provide comprehensive cancer care services. The program can also serve as a platform for performing cellular therapy procedures such as chimeric antigen receptor T-cell therapies. This chapter reviews the potential pathways to establish an HCT and cellular therapy program along with recommendations on the required infrastructure and personnel. In addition, the chapter provides the foundation for establishing a robust quality program and the resources required for data and research.
Building Quality from the Ground Up in a Cancer Center
Authors: Babar Arslan , Montero Alberto J. 
Published: October 2021

AbstractThe Institute of Medicine defines quality in healthcare as the degree to which health services for individuals and populations increase the likelihood of desired health outcomes and are consistent with current professional knowledge. This concept is highly relevant for cancer care that involves patients with complex diseases in the setting of rapidly evolving treatment landscape that requires provision of appropriate services in a patient-centric and technically competent manner. This chapter uses the Donabedian model to review the structural, process, and outcome-based quality domains that lay the foundation for a robust system to measure, monitor, and improve quality of care at cancer centers. The infrastructure and personnel, systems, and culture needed for ensuring provision of high-quality cancer care are reviewed.
Data Unit, Translational Research, and Registries
Authors: Hussain Fazal , Alhayli Saud , Aljurf Mahmoud 
Published: October 2021

AbstractResearch is the only way to challenge the existing standards of care; a dynamic and multidimensional process encompassing innovative therapeutic modalities, techniques, and interventions to optimize outcomes and quality of life of cancer patients. Cancer research has emerged as one of the core competencies for the standardization, accreditation, and academic standing of any comprehensive cancer center. Data unit is the center of gravity and the hub of research and development (databases, registries, translational research, randomized control trials) in a quality cancer care facility. Quality assurance, ethical conduct, and monitoring of research are the hallmarks of a center of excellence in galvanizing the research efforts and optimizing the quality outcomes.
Education and Training
Authors: Murthy Hemant S. , Manochakian Rami , Kharfan-Dabaja Mohamed A. 
Published: October 2021

AbstractAt the heart of every comprehensive cancer center is education and training. The prominence of a cancer center is often correlated to the strength of their educational and training programs. Education is responsible for training the next generation of clinicians, advanced practice providers, nurses, other supporting staff, and researchers. This chapter provides the framework of education and training, specific to different disciplines, within a comprehensive cancer center. In addition, it discusses education beyond training, such as maintaining educational standards, and developing new programs that embrace the continuous advances in cancer care.
The Infusion Center
Authors: Kharfan-Dabaja Mohamed A. 
Published: October 2021

AbstractAvailability of more effective supportive therapies coupled with emergence of novel antineoplastic agents has facilitated administration of cancer treatments outside the hospital setting. Cancer treatments typically require multiple visits. Accordingly, it can be exhausting for patients and their caregivers who are already under a lot of stress including physical, emotional and financial strain, among others. Infusion centers allow providers to help patients better manage and control their disease and associated symptoms by providing a continuity of care throughout their medical need, enhancing continuity of care and improving compliance. Here, we described the major components required for successful operation of a cancer infusion center. The ultimate goal is to offer a patient-centered experience that improves the overall quality of delivered care at a sustainable cost.
Proposal for Establishing a New Radiotherapy Facility
Authors: Aldehaim Mohamed , Phan Jack 
Published: October 2021

AbstractCancer is a growing burden globally. Radiotherapy has proven to be a critical and cost-effective treatment modality for a cure in greater than 50% of cancer patients. There are numerous obstacles and challenges in establishing new radiotherapy facilities and programs, especially in low- and middle-income countries. It is known that the clinical aspect, as well as procedure related to the physical and technical aspect of patient treatment, needs to be subjected to careful planning in order to ensure safe and high-quality radiotherapy. This process required the engagement of various professionals from different backgrounds.This chapter aims to define radiotherapy value, assessing a radiation facility’s clinical, infrastructure, and resources need to establish a new radiotherapy facility.
The 4d superconformal index near roots of unity and 3d Chern-Simons theory
Authors: Ardehali Arash Arabi , Murthy Sameer 
Published: October 2021

Abstract
We consider the S3×S1 superconformal index ℐ(τ) of 4d $$ \mathcal{N} $$
N
= 1 gauge theories. The Hamiltonian index is defined in a standard manner as the Witten index with a chemical potential τ coupled to a combination of angular momenta on S3 and the U(1) R-charge. We develop the all-order asymptotic expansion of the index as q = e2πiτ approaches a root of unity, i.e. as $$ \overset{\sim }{\tau } $$

τ
~

≡ mτ+n → 0, with m, n relatively prime integers. The asymptotic expansion of log ℐ(τ) has terms of the form $$ \overset{\sim }{\tau } $$

τ
~

k, k = −2, −1, 0, 1. We determine the coefficients of the k = −2, −1, 1 terms from the gauge theory data, and provide evidence that the k = 0 term is determined by the Chern-Simons partition function on S3/ℤm. We explain these findings from the point of view of the 3d theory obtained by reducing the 4d gauge theory on the S1. The supersymmetric functional integral of the 3d theory takes the form of a matrix integral over the dynamical 3d fields, with an effective action given by supersymmetrized Chern-Simons couplings of background and dynamical gauge fields. The singular terms in the $$ \overset{\sim }{\tau } $$

τ
~

→ 0 expansion (dictating the growth of the 4d index) are governed by the background Chern-Simons couplings. The constant term has a background piece as well as a piece given by the localized functional integral over the dynamical 3d gauge multiplet. The linear term arises from the supersymmetric Casimir energy factor needed to go between the functional integral and the Hamiltonian index.
New AdS2 supergravity duals of 4d SCFTs with defects
Authors: Lozano Yolanda , Petri Nicolò , Risco Cristian 
Published: October 2021

Abstract
We construct new families of AdS2× S2× S2 solutions with 4 supercharges in Type II supergravities. We show that subclasses of these solutions can be interpreted in terms of defect branes embedded in 4d $$ \mathcal{N} $$
N
= 4 SYM, or orbifolds thereof. This is explicitly realised by showing that the solutions asymptote locally to AdS5× S5/ℤn, in Type IIB, or its T-dual background, in Type IIA. The latter is a Gaiotto-Maldacena geometry realised on an intersection of D4 and NS5 branes. We extend the Type IIA solutions to include D6 branes, and interpret them as describing backreacted baryon vertices within 4d $$ \mathcal{N} $$
N
= 2 CFTs living in D4-NS5-D6 intersections. We propose explicit quiver quantum mechanics in which the defect branes play the role of colour branes, with the D4 branes of the D4-NS5-D6 intersection becoming flavour branes. These quivers are used to compute the degeneracies of the ground states of the dual super conformal quantum mechanics, that are shown to agree with the holographic expressions.