bluuebunny/crossref_metadata_2025_split huggingface dataset:
Team-Based Care for Improving Hypertension Management: A Pragmatic Randomized Controlled Trial
Authors: Santschi Valérie , Wuerzner Gregoire , Pais Bruno , Chiolero Arnaud , Schaller Philippe , Cloutier Lyne , Paradis Gilles , Burnier Michel 
Published: October 2021

Objective: We evaluated the effect on long term blood pressure (BP) of an interprofessional team-based care (TBC) intervention, involving nurses, pharmacists, and physicians, compared to usual care.Methods: We conducted a pragmatic randomized controlled study in ambulatory clinics and community pharmacies in Switzerland (ClinicalTrials.gov: NCT02511093). Uncontrolled treated hypertensive patients were randomized to TBC or usual care (UC). In the TBC group, nurses and pharmacists met patients every 6 weeks to measure BP, assess lifestyle, support medication adherence, and provide health education for 6 months. After each visit, they wrote a report to the physician who could adjust antihypertensive therapy. The outcome was the intention-to-treat difference in mean daytime ambulatory blood pressure measurement (ABPM) and control (&lt;135/85 mmHg) at 6 and 12 months.Results: Eighty-nine patients (60 men/29 women; mean (SD) age: 61(12) year) were randomized to TBC (n = 43) or UC (n = 46). At baseline, mean (SD) BP was 144(10)/90(8) mmHg and 147(12)/87(11) mmHg in the TBC and UC groups. At 6 months, the between-groups difference in daytime systolic ABPM was−3 mmHg [95% confidence interval (CI):−10 to +4; p = 0.45]; at 12 months, this difference was−7 mmHg [95% CI:−13 to−2; p = 0.01]. At 6 months, the between-groups difference in daytime diastolic ABPM was +2 mmHg [95% CI:−1 to +6; p = 0.20]; at 12 months, this difference was−2 mmHg [95% CI:−5 to +2; 0.42]. Upon adjustment for baseline covariates including baseline BP, the between-groups differences at 6 and 12 months were maintained. At 6 months, there was no difference in BP control. At 12 months, the TBC group tended to have a better control in systolic BP (p = 0.07) but not in diastolic BP (p = 0.33).Conclusion: While there was not significant effect on BP at 6 months of follow-up, the TBC intervention can help decrease long-term systolic BP among uncontrolled hypertensive patients.
The Short-Term Climate Prediction System FIO-CPS v2.0 and its Prediction Skill in ENSO
Authors: Song Yajuan , Shu Qi , Bao Ying , Yang Xiaodan , Song Zhenya 
Published: October 2021

The climate model is an important tool for simulating and predicting the mean state and variability of the climate system. The First Institute of Oceanography-Climate Prediction System (FIO-CPS), built on a climate model with the oceanic observation initialization, has been updated from version 1.0 to 2.0, with a finer resolution and more reasonable physical processes. Previous assessments show that the mean state was well simulated in version 2.0, and its influence on the prediction was further analyzed in this study. Hindcast experiments were conducted using FIO-CPS v1.0 and v2.0, and their prediction abilities based on 27 years (1993–2019) experiment data were analyzed. The results show that the sea surface temperature (SST) biases over the eastern Pacific and the Southern Ocean are improved in the initial condition of FIO-CPS v2.0. Moreover, this new system has a higher skill for predicting El Niño-Southern Oscillation (ENSO). The prediction skill represented by the anomaly correlation coefficient (ACC) of the Niño3.4 index is greater than 0.78 at the 6-month lead time, which increases by 11.09% compared to the value of 0.70 in FIO-CPS v1.0. The root mean square error (RMSE) decreases by 0.20, which accounts for 28.59% of the FIO-CPS v1.0 result. Furthermore, the improvement of the prediction skill changes seasonally, featured by the ACC significantly increasing in the boreal winter and early spring. The improvement in the annual mean SST prediction over the Equatorial Pacific mainly contributes to the enhanced ENSO prediction skill in FIO-CPS v2.0. These results indicate that a state-of-the-art climate model with a well-simulated mean state is critical in improving the prediction skill on the seasonal time scale.
The Transcriptome Characteristics of Severe Asthma From the Prospect of Co-Expressed Gene Modules
Authors: Li Bin , Sun Wen-Xuan , Zhang Wan-Ying , Zheng Ye , Qiao Lu , Hu Yue-Ming , Li Wei-Qiang , Liu Di , Leng Bing , Liu Jia-Ren , Jiang Xiao-Feng , Zhang Yan 
Published: October 2021

Rationale: Severe asthma is a heterogeneous disease with multiple molecular mechanisms. Gene expression studies of asthmatic bronchial epithelial cells have provided biological insights and underscored possible pathological mechanisms; however, the molecular basis in severe asthma is still poorly understood.Objective: The objective of this study was to identify the features of asthma and uncover the molecular basis of severe asthma in distinct molecular phenotype.Methods: The k-means clustering and differentially expressed genes (DEGs) were performed in 129 asthma individuals in the Severe Asthma Research Program. The DEG profiles were analyzed by weighted gene co-expression network analysis (WGCNA), and the expression value of each gene module in each individual was annotated by gene set variation analysis (GSVA).Results: Expression analysis defined five stable asthma subtype (AS): 1) Phagocytosis-Th2, 2) Normal-like, 3) Neutrophils, 4) Mucin-Th2, and 5) Interferon-Th1 and 15 co-expressed gene modules. “Phagocytosis-Th2” enriched for receptor-mediated endocytosis, upregulation of Toll-like receptor signal, and myeloid leukocyte activation. “Normal-like” is most similar to normal samples. “Mucin-Th2” preferentially expressed genes involved in O-glycan biosynthesis and unfolded protein response. “Interferon-Th1” displayed upregulation of genes that regulate networks involved in cell cycle, IFN gamma response, and CD8 TCR. The dysregulation of neural signal, REDOX, apoptosis, and O-glycan process were related to the severity of asthma. In non-TH2 subtype (Neutrophils and Interferon-Th1) with severe asthma individuals, the neural signals and IL26-related co-expression module were dysregulated more significantly compared to that in non-severe asthma. These data infer differences in the molecular evolution of asthma subtypes and identify opportunities for therapeutic development.Conclusions: Asthma is a heterogeneous disease. The co-expression analysis provides new insights into the biological mechanisms related to its phenotypes and the severity.
Rapid and Sensitive Diagnosis of Drug-Resistant FLT3-F691L Mutation by CRISPR Detection
Authors: Liu Yin , Chen Yanling , Huang Shisheng , Ma Xiaodong , Huang Xingxu , Wang Xinjie , Zhou Fuling 
Published: October 2021

Sensitive and efficient detection of drug-resistant mutations is essential in cancer precision medicine. In treating acute myeloid leukemia (AML), FLT3 gene F691L mutation shows universal resistance to all currently available FLT3 inhibitors. However, there is no particular detection method for FLT3-F691L. Commonly-used first-generation sequencing (FGS) approaches have low sensitivity, and next-generation sequencing (NGS) is time-consuming. Herein, we developed an accurate and sensitive FLT3-F691L diagnostic method by CRISPR detection. Briefly, the FLT3-691 region is amplified by recombinase polymerase amplification (RPA) and detected by L691-crRNA induced Cas12a reaction, and finally the result can be directly observed under a blue lamp or analyzed by a fluorescence reader. Confirmed by the tests on diluted plasmids and 120 AML patient samples, this method can achieve a sensitivity of 0.1% and complete the whole diagnosis process within 40 min. Potentially, this method will play an important role in point-of-care applications and guidance of AML treatment.
High-Risk Features Are Prognostic in dMMR/MSI-H Stage II Colon Cancer
Authors: Mohamed Amr , Jiang Renjian , Philip Philip A. , Diab Maria , Behera Madhusmita , Wu Christina , Alese Olatunji , Shaib Walid L. , Gaines Tyra M. , Balch Glen G. , El-Rayes Bassel F. , Akce Mehmet 
Published: October 2021

BackgroundHigh-risk features, such as T4 disease, bowel obstruction, poorly/undifferentiated histology, lymphovascular, perineural invasion, and &lt;12 lymph nodes sampled, indicate poor prognosis and define high-risk stage II disease in proficient mismatch repair stage II colon cancer (CC). The prognostic role of high-risk features in dMMR/MSI-H stage II CC is unknown. Similarly, the role of adjuvant therapy in high-risk stage II CC with dMMR/MSI-H (≥1 high-risk feature) has not been studied in prospective trials. The aim of this analysis of the National Cancer Database is to evaluate the prognostic value of high-risk features in stage II dMMR/MSI-H CC.MethodsUnivariate (UVA) and multivariate (MVA) Cox proportional hazards (Cox-PH) models were built to assess the association between clinical and demographic characteristics and overall survival. Kaplan–Meier survival curves were generated with log-rank tests to evaluate the association between adjuvant chemotherapy in high-risk and low-risk cohorts separately.ResultsA total of 2,293 stage II CC patients have dMMR/MSI-H; of those, 29.5% (n = 676) had high-risk features. The high-risk dMMR/MSI-H patients had worse overall survival [5-year survival and 95%CI, 73.2% (67.3–78.1%) vs. 80.3% (76.7–83.5%), p = 0.0001]. In patients with stage II dMMR/MSI-H CC, the high-risk features were associated with shorter overall survival (OS) along with male sex, positive carcinoembryonic antigen, Charlson–Deyo score &gt;1, and older age. Adjuvant chemotherapy administration was associated with better OS, regardless of the high-risk features in dMMR/MSI-H (log-rank test, p = 0.001) or not (p = 0.0006). When stratified by age, the benefit of chemotherapy was evident only in patients age ≥65 with high-risk features.ConclusionHigh-risk features are prognostic in the setting of dMMR/MSI-H stage II CC. Adjuvant chemotherapy may improve survival specifically in patients ≥65 years and with high-risk features.
Long-Term Functional Outcomes After Sepsis for Adult and Pediatric Critical Care Patients—Protocol for a Systematic Review
Authors: Simpson Adam , Long Deborah , Fleischmann-Struzek Carolin , Minogue Jessicah , Venkatesh Balasubramanian , Hammond Naomi E. , Tian David H. , Schlapbach Luregn J. 
Published: October 2021

Objective: Sepsis is responsible for a massive burden of disease, with a global estimate of 48.9 million cases resulting in approximately 11 million deaths annually. Survivors of sepsis may also experience long-term impairments that can persist for years after hospital discharge. These cognitive, physical and/or psychosocial deficits may contribute to a lower health related quality of life and represent a significant ongoing burden to the individual, the community and the health care system. We aim to systematically review the available evidence on long-term functional and quality of life outcomes after sepsis in children and adults.Data Sources: Medline, EMBASE, and CINAHL will be searched for eligible studies.Study Selection: Studies of adult and pediatric survivors of sepsis who had required admission to intensive care will be included. A minimum 6 month prospective follow up will be required. Accepted outcomes will be any validated measure of health-related quality of life (HRQoL) or functional deficits, using the Post-Intensive Care Syndrome (PICS) framework of cognitive, physical or psychosocial outcomes.Data Extraction: Data extraction will include information related to study characteristics, population characteristics, clinical criteria and outcomes.Data Synthesis: Studies meeting the inclusion criteria will be presented descriptively separated for pediatric and adult age groups. Meta-analysis will be attempted if sufficient primary data from several studies applying the same tests and outcomes are available. The primary outcome is HRQoL after sepsis; secondary outcomes include the functional status at follow-up.Conclusions: This systematic review will define the long-term impact of sepsis survivorship. The data will contribute to informing patient, clinician and stakeholder decisions and guide further research and resource management.
Development of a High Performance 1280×1024 InGaAs SWIR FPA Detector at Room Temperature
Authors: Zhang Jia-Xin , Wang Wei , Li Zai-Bo , Ye Hai-Feng , Huang Run-Yu , Hou Ze-Peng , Zeng Hui , Zhu Hong-xia , Liu Chen , Yang Xue-Yan , Shi Yan-Li 
Published: October 2021

A 1280 × 1,024 In0.53Ga0.47As short wave infrared (SWIR) focal plane array (FPA) detector with a planar-type back-illuminated process has been fabricated. With indium bump flip-chip bonding techniques, the InGaAs photodiode arrays were hybrid-integrated to the CMOS readout integrated circuit (ROIC) with correlated double sampling (CDS). The response spectrum is 0.9–1.7 μm. The test results show that the dark current density is 2.25 nA/cm2 at 25 °C, the detectivity D* is up to 1.1 × 1013 cm · Hz1/2/W, the noise electron is as low as 48 e− under correlated double sampling mode, the quantum efficiency is 88% at 1550 nm, and the operability is more than 99.9%. Moreover, the dark current and noise electron have been studied theoretically in depth. The results indicate that the diffusion current is the main contribution of the dark current, and the readout integrated circuit noise electron is the main source of FPA noise.
The Frequency of Communication Between the Synovial Compartments of the Equine Temporomandibular Joint: A Contrast-Enhanced Computed Tomographic Assessment
Authors: Pimentel Karen L. , Carmalt James L. 
Published: October 2021

Background: There is conflicting evidence regarding communication between the two compartments of the equine temporomandibular joint (TMJ). Understanding the inter-relationship between TMJ compartments is critical for diagnostic and clinical management purposes.Objective: To determine the frequency of communication between the discotemporal joint (DTJ) and the discomandibular joint (DMJ) of the equine TMJ in horses free of overt disease.Study Design: A randomized, blinded, controlled cadaveric study.Methods: Equine cadaver heads (n = 20), with no reported history of potential TMJ disease, were collected and stored frozen until use. Horses were randomized to the treatment group, such that Group A horses (n = 10) underwent arthrocentesis of the left DTJ and the right DMJ compartments, while Group B (n = 10) underwent arthrocentesis of the left DMJ and the right DTJ compartments of the TMJ, for a total of 40 joints. Computed tomography (CT) imaging was performed before, and after, intra-articular injection of contrast media in each head. Two observers, blinded to the treatment group, independently interpreted CT images.Results: Communication between synovial compartments occurred in the left TMJ of two horses. Arthroscopic evaluation revealed that both horses had a perforation of the intra-articular disc in the region of the caudomedial fibrous expansion. Mild anterior displacement of the abnormal disc in the joint of one horse was demonstrated using magnetic resonance imaging (MRI).Main Limitations: Sample size, the use of owner provided animals' history, and frozen specimens.Conclusions: No physiological communication was present between the DTJ and the DMJ in the equine TMJ of the cases studied, regardless of which compartment underwent arthrocentesis. Two joints had pathological communications. These results suggest that diagnostic, and medical, treatment of intra-articular disease may be most effective when both joint compartments are injected. Furthermore, this study illustrates the value of contrast enhancement while imaging the equine TMJ.
Comparative analysis of legal regulation of higher education in Germany and Finland
Authors: Мякинина С.Б. 
Published: October 2021

для анализа современного правового регламентирования системы высшего образования выбраны две страны, образовательные модели которых были изучены автором непосредственно в этих странах. В статье рассматриваются избранные страны как диаметрально различные как по форме государственного устройства, что повлияло на законодательную базу, так и по подходу к реализации Болонской декларации о создании общеевропейского пространства высшего образования. Несмотря на то, что Германия реализует классическую модель образовательного процесса, а финское образование является во многом новаторским, обе эти страны добились высоких качественных показателей и занимают лидирующее положение университетского образования в Европе. Данный анализ полезен для дальнейшего совершенствования правового регулирования образования в России.
to analyze the modern legal regulation of the higher education system, two countries were selected, the educational models of which were studied by the author directly in these countries. The article examines the selected countries as diametrically different both in the form of government, which influenced the legislative framework, and in the approach to the comprehension of the Bologna Declaration for the creation of a common field of European Higher Education. Even though Germany implements the classical model of the educational process, and Finnish education is in many ways innovative – both countries have achieved high quality indicators and occupy a leading position in university education in Europe. This analysis is useful for further improving the legal regulation of education in Russia.
On the issue of training education managers to manage the risks of an educational organization
Authors: Савенкова Е.В. 
Published: October 2021

в статье рассматривается необходимость подготовки в педагогическом вузе менеджеров образования к управлению рисками в образовательной организации. В реальных практических ситуациях менеджеры образования сталкиваются с рядом проблем, среди которых значительное место занимает принятие решений в условиях неопределенности и риска. Подготовка в педагогическом вузе менеджеров образования позволяет обеспечить формирование рискологической компетентности при обучении по основным образовательным программам и дополнительным профессиональным программам профессиональной переподготовки.
the article discusses the need to train education managers in a pedagogical university to manage risks in an educational organization. In real practical situations, education managers face several problems, among which a significant place is occupied by decision-making in conditions of uncertainty and risk. The training of education managers in a pedagogical university allows for the formation of risk-based competence in training in the main educational programs and additional professional programs of professional retraining.
LOCO: The 88-million-word language of conspiracy corpus
Authors: Miani Alessandro , Hills Thomas , Bangerter Adrian 
Published: October 2021

AbstractThe spread of online conspiracy theories represents a serious threat to society. To understand the content of conspiracies, here we present the language of conspiracy (LOCO) corpus. LOCO is an 88-million-token corpus composed of topic-matched conspiracy (N = 23,937) and mainstream (N = 72,806) documents harvested from 150 websites. Mimicking internet user behavior, documents were identified using Google by crossing a set of seed phrases with a set of websites. LOCO is hierarchically structured, meaning that each document is cross-nested within websites (N = 150) and topics (N = 600, on three different resolutions). A rich set of linguistic features (N = 287) and metadata includes upload date, measures of social media engagement, measures of website popularity, size, and traffic, as well as political bias and factual reporting annotations. We explored LOCO’s features from different perspectives showing that documents track important societal events through time (e.g., Princess Diana’s death, Sandy Hook school shooting, coronavirus outbreaks), while patterns of lexical features (e.g., deception, power, dominance) overlap with those extracted from online social media communities dedicated to conspiracy theories. By computing within-subcorpus cosine similarity, we derived a subset of the most representative conspiracy documents (N = 4,227), which, compared to other conspiracy documents, display prototypical and exaggerated conspiratorial language and are more frequently shared on Facebook. We also show that conspiracy website users navigate to websites via more direct means than mainstream users, suggesting confirmation bias. LOCO and related datasets are freely available athttps://osf.io/snpcg/.
Ground beetle fauna (Coleoptera, Carabidae) of Mordovia State Nature Reserve (Russia)
Authors: Ruchin Alexander , Alekseev Sergey , Egorov Leonid , Artaev Oleg , Semishin Gennadiy , Esin Mikhail 
Published: October 2021

Protected areas are organised in different climatic zones, which usually include typical ecosystems characteristic of certain climatic zones. In most cases, protected areas are biodiversity hotspots. These areas are benchmarks in terms of nature conservation and to determine their biological diversity is becoming an important task. It is important to investigate the carabid family of protected areas within the framework of understanding the overall biological diversity of these systems. In addition, ground beetles, as one of the largest groups of ground-based inhabitants, are indicators of the state of ecosystems and serve as markers of their well-being.
We present 2,969 new occurrence records comprising 226 species of Carabidae, belonging to eight subfamilies, from the Mordovia State Nature Reserve (central Russia). Ten species are listed for the first time for the Mordovia State Nature Reserve fauna after previous research: Cicindela maritima, Bembidion striatum, Dyschirius angustatus, Dyschirius arenosus, Notiophilus aestuans, Bembidion argenteolum, Bembidion velox, Bradycellus caucasicus, Cymindis angularis and Syntomus truncatellus, five of which were first recorded for the Republic of Mordovia (Egorov et al. 2020). Previously, this information was not published anywhere and we wanted to make it available to everyone by embedding it in the global database on biodiversity (GBIF).
La Recherche et l’Innovation en France
Authors: Bouquin Nadège 
Published: October 2021

Si les moyens dévolus aux universités ont augmenté dans la période récente, les financements supplémentaires mis à la disposition des acteurs suscitent des interrogations : distorsions entre affichages et réalités ou, en tout cas, compréhension difficile du rapport entre les deux, décroissance en fin de période, modalités d’allocation complexes et peu cohérentes. Face à ces constats, les pistes de propositions se concentrent autour de trois axes. Tout d’abord, il conviendrait de simplifier et de stabiliser un dispositif de financement public des établissements reposant sur les deux outils principaux que sont le modèle Sympa et le contrat quinquennal État-université, après avoir ajusté le premier et renforcé le second. Ensuite, les universités devraient pouvoir poursuivre leur marche vers l’autonomie, car leur quête des moyens de leur développement se heurte à des obstacles structurels majeurs : comment développer des stratégies et des projets d’établissements lorsqu’on n’a de prise réelle ni sur ses ressources humaines, ni sur ses flux d’étudiants, ni sur son patrimoine et ses infrastructures ? Il faut continuer à progresser vers tout ce qui permettrait de donner davantage de capacité de vision et d’action aux responsables universitaires, ce qui implique notamment des circuits de décision, de financement et d’action raccourcis et plus cohérents. Enfin, il importe que le cœur de métier de l’université, à savoir la formation, fasse l’objet d’un investissement important, aussi bien en termes d’organisation et de gestion qu’en termes de développement et de pilotage d’une offre globale mieux ciblée. En conclusion, le développement de la capacité stratégique des universités dépend aujourd’hui largement d’une autonomie accrue, de moyens maintenus ou renforcés sur lesquels elles aient une visibilité suffisante, et, au-delà, de la poursuite des efforts de rapprochement des différentes filières de l’enseignement supérieur.