bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of graphene oxide content on the morphology and properties of carbon fiber/epoxy composites
Authors: Ma Yuqin , Zhao Yatao , Li Fei , Xu Yiren , Wei Xinliang , Chen Yi , Wang Jie , Jin Hao 
Published: August 2021

AbstractIn this article, the influence of graphene oxide (GO) content on the morphology and properties of carbon fiber/epoxy (CF/EP) composites was investigated. To obtain CF/EP composites with uniform dispersion of GO, electromagnetic stirring and ultrasonic dispersion techniques were employed in the wet transfer process. Combined with a new molding process, CF/EP composites with different GO content were prepared. The test results showed that the bending strength of CF/EP composites could be effectively improved by adding GO, among which 0.5 wt% GO–CF/EP composite exhibited the best bending strength and modulus increased by 47.20% and 21.24%, up to 1158.9 MPa and 115.3 GPa. Likewise, the mode I interlaminar fracture toughness (GIC) of the composite at the beginning of crack and the maximum during the propagation increased by 28.13% and 21.57%, reached 327.5 and 656.6 J/m2, respectively. The distribution of GO in the composites and the fracture morphology of the composites were observed. Finally, according to the test results and microscopic morphology analysis, the enhancement and failure mechanism of GO in CF/EP composites were clarified. It was found that GO could improve the properties of CF/EP composites by enhancing the interface properties of CF/matrix, enhancing the strength of the matrix and forming a net‐like structure inside the matrix.
Pediatric P‐ANCA vasculitis following COVID‐19
Authors: Fireizen Yaron , Shahriary Cyrus , Imperial Maria E. , Randhawa Inderpal , Nianiaris Nastasia , Ovunc Bugsu 
Published: August 2021

AbstractBackgroundPerinuclear anti‐neutrophil cytoplasmic antibodies (P‐ANCA) are associated with a multisystem vasculitis affecting small blood vessels in the body. A handful of adult patients who developed vasculitis post‐COVID‐19 have been reported. Although SARS‐CoV‐2 has been shown to drive an exaggerated immune response in the pediatric population, such as in Multisystem Inflammatory Syndrome in Children (MIS‐C), only one case of vasculitis following COVID‐19 has been reported previously in children.Case presentationSeventeen‐year‐old male with a past medical history of COVID‐19 pneumonia two months prior presented with acute kidney injury and diffuse alveolar hemorrhage. Rheumatologic workup revealed P‐ANCA and Myeloperoxidase (MPO) positivity. Kidney biopsy showed necrotizing glomerulonephritis with limited immune complex deposition. Subsequently, he was treated with steroids and plasmapheresis, and ultimately started on cyclophosphamide.ConclusionsTo our knowledge, this report presents the second reported pediatric case of P‐ANCA/MPO vasculitis following COVID‐19.
Structural stability and thermodynamic properties of (Y2O3)n (n = 1–15) clusters based on density functional theory
Authors: Jiang Xin , Zhang Zhenming , Luo Diqiang , You Jinglin , Lai Chaobin 
Published: August 2021

AbstractThe initial configuration of Yttrium oxide clusters (Y2O3)n (n = 1–15) was creatively constructed by combining artificial bee colony algorithm with density functional theory. The structures of large and medium‐sized yttrium oxide clusters with molecular number greater than 10 were established for the first time, and many new structures that are different from existing research have been obtained. Studies have shown that for small‐sized clusters, the atomic stacking structure is cage‐like, while for medium‐sized and large‐sized clusters, the composite trapezoidal structure and ellipsoid‐like structure are more stable. The nanoclusters tend to be stable as a whole, and the relative stability of the cluster structure is higher when n = 2, 4, 7, 9. The heat capacity (Cp), enthalpy change (H) and entropy (S) of (Y2O3)n (n = 1–15) clusters increase with the increase of temperature (T), and the vibration free energy (Gv) decreases with the increase of T.
The expression of human testis‐specific actin capping protein predicts in vitro fertilization outcomes: A novel biomarker of sperm function for assisted reproductive technology
Authors: Inagaki Yusuke , Fukuhara Shinichiro , Kuribayashi Sohei , Okada Koichi , Sekii Yosuke , Takezawa Kentaro , Kiuchi Hiroshi , Soda Tetsuji , Miyagawa Yasushi , Okamoto Yoshio , Tanaka Hiromitsu , Nonomura Norio 
Published: August 2021

AbstractPurposeSperm function tests do not adequately assess fertilization potential, and new indices are required. We have previously reported that human testis‐specific actin capping proteins may be involved in both sperm morphology and function. This study aimed to determine whether testis‐specific actin capping proteins can be a predictive marker of IVF success.MethodsNinety‐seven infertile couples who underwent IVF at an infertility clinic were included. Sperm were immunohistochemically stained to evaluate capping protein expression, and the percentage of sperms with normal staining was calculated. The relationship between actin capping protein expression and IVF outcomes was examined.ResultsThe couples were divided into four groups according to the percentage of normally expressing actin capping protein as follows: ≥90% Group Ⅰ, 80%–90% Group Ⅱ, 70%–80% Group Ⅲ, and <70% Group Ⅳ. Multiple regression analysis showed a significant trend in fertilization rates across the 4 groups (p for trend =0.008).There was no significant trend in pregnancy rates (p for trend =0.276).ConclusionThe human testis‐specific actin capping protein may be a marker of male contributing factors that predict IVF outcomes.
Modern Trends in the Applications of Perovskites for Selective Organic Transformations
Authors: Chandra Prakash 
Published: August 2021

AbstractPerovskites have captivated the interest of contemporary synthetic chemists in both the academic and industrial sector due to their multifarious physicochemical properties like excellent thermal stability, oxygen mobility substitution of A and B cations. These perovskite based mixed metal oxides effectively promote selective organic transformations like selective oxidation reactions, selective hydrogenation reactions, nitro to amine reduction, carbon‐carbon and carbon hetero‐bond forming reactions. Furthermore, these mixed metal oxide perovskites have been investigated for the multi‐component domino reactions for synthesis of valuable organic compounds. Recently, metal halide perovskites have emerged as futuristic materials for the catalytic and photocatalytic selective organic transformations to form valuable organic compounds. The present review mainly addresses the recent developments in the catalytic and photocatalytic applications of perovkites in organic synthesis in the past 10 years.
A photosensitized metal free approach to α‐ketoamides:sequential oxidative amidationdiketonization of terminal alkynes
Authors: Manhas Farah Manzer , Raheem Shabnam , Kumar Jaswant , Thakur Pankaj , Rizvi Masood Ahmad 
Published: August 2021

AbstractA novel transition metal‐free photosensitized protocol has been developed for the synthesis of α‐ketoamides via oxidative coupling of alkynes and amines in the presence of thiophenol under visible light irradiation and rose bengal dye. A series of alkynes with both electron‐donating and electron‐withdrawing groups were successfully employed for the synthesis of their corresponding α‐ketoamides. This reaction presents a benign visible light based milder synthetic methodology with broad functional‐group tolerance.
Computational Studies of Selected Transition Metal Complexes as Potential Drug Candidates against the SARS‐CoV‐2 Virus
Authors: Pal Maynak , Musib Dulal , Zade Aniket J. , Chowdhury Neeta , Roy Mithun 
Published: August 2021

AbstractThe earth has witnessed the greatest global health crisis due to the outbreak of the SARS‐CoV‐2 virus in late 2019, resulting in the pandemic COVID‐19 with 3.38 million mortality and 163 million infections across 222 nations. Therefore, there is an urgent need for an effective therapeutic option against the SARS‐CoV‐2 virus. Transition metal complexes with unique chemical, kinetic and thermodynamic properties have recently emerged as the viable alternative for medicinal applications. Herein, the potential application of selected antiviral transition metal‐based compounds against the SARS‐CoV‐2 virus was explored in silico. Initially, the transition metal‐based antiviral compounds (1‐5) were identified based on the structural similarity of the viral proteins (proteases, reverse transcriptase, envelop glycoproteins, etc.) of HIV, HCV, or Influenza virus with the proteins (S‐protein, RNA‐dependent RNA polymerase, proteases, etc) of SARS‐CoV‐2 virus. Hence the complexes (1‐5) were subjected to ADME analysis for toxicology and pharmacokinetics report and further for the molecular docking calculations, selectively with the viral proteins of the SARS‐CoV‐2 virus. The molecular docking studies revealed that the iron‐porphyrin complex (1) and antimalarial drug, ferroquine (2) could be the potential inhibitors of Main protease (Mpro) and spike proteins respectively of SARS‐CoV‐2 virus. The complex 1 exhibited high binding energy of −11.74 kcal/mol with the Mpro of SARS‐CoV‐2. Similarly ferroquine exhibitred binding energy of −7.43 kcal/mol against spike protein of SARS‐CoV‐2. The complex 5 also exhibited good binding constants values of −7.67, −8.68 and −7.82 kcal/mol with the spike protein, Mpro and RNA dependent RNA polymerase (RdRp) proteins respectively. Overall, transition metal complexes could provide an alternative and viable therapeutic solution for COVID‐19.
New Insights into the Catalytic Activity and Reusability of Water‐Soluble Silver Nanoparticles
Authors: Monti Gustavo A. , Correa N. Mariano , Falcone R. Darío , Silbestri Gustavo F. , Moyano Fernando 
Published: August 2021

AbstractSilver nanoparticles (AgNPs) ‐stabilized by different sulfonated imidazolium salts (Lx)‐ have been synthesized as potential recyclable and reusable catalysts for the reduction of nitroaromatic compounds in water. An exhaustive study of the catalytic activity is presented and kinetic data are explained in terms of the Langmuir–Hinshelwood model. The kinetic parameters and the performance of AgNP as catalysts were determined. The results reveal that catalysis is a superficial process and the reaction rate depends on the type of AgNP:Lx used as catalyst, with the imidazolium salts having the effects on the catalytic activity. The physicochemical and structural characteristics of AgNPs are factors that influence the catalytic efficiency. The fact that these catalysts are recycled, in some cases for more than 6 cycles, opens a way for their recovery and reuse of AgNPs. Finally, a comparative study with gold nanoparticles (AuNP) stabilized by the same salts has been realized.
Counterion Effect on the Mechanism of Gold(I)‐Catalyzed Cycloisomerization of 3‐Allenylmethylindoles to 4,9‐Dihydro‐1H‐Carbazoles: A Computational Study
Authors: Menkir Mengistu G. , Lee Shyi L. 
Published: August 2021

AbstractA detail computational investigation of the mechanism of the title reaction has been carried out with density functional theory (DFT) method to make clear the role of counterion and the regiochemistry of the initial nucleophilic attack of the indole core on the alkylating agent (i. e. C2 vs C3 position). The calculated results suggest that 6‐endo‐trig cyclization followed by bistriflimide counterion‐assisted proton transfer could account for the formation of the final product. In other words, intramolecular nucleophilic attack by C2 of the indole group towards the terminal carbon atom of the allene moiety leads to the formation a 6‐membered ring fused indolyl intermediate, which undergoes deprotonation and protodemetallation to give the final product. Of the three steps, the rate determining step of the whole catalytic cycle is the deprotonation step with an activation free energy of 14.4 kcal/mol. It is also found that the regiochemistry of the initial nucleophilic attack of the indole moiety on the cationic gold‐activated allene moiety is dependent on the conformation of reactant complex, the nature of substituent in the allene moiety and the size of phosphine ligand.
Feasibility of the Big 5—Jena eCS Protocol
Authors: Molina-Fuentes Moisés F. , Neumann Rotraud , Behringer Wilhelm , Franz Marcus , Schulze P. Christian , Witte Otto W. , Günther Albrecht , Klingner Carsten , Lehmkuhl Lukas , Steiniger Beatrice , Teichgräber Ulf , Rod J. E. , Mayer Thomas E. 
Published: August 2021

Abstract
Purpose
The most common protocols in the initial diagnostic of acute ischemic stroke do not assess cardiogenic or aortic causes of embolism. These are usually evaluated later by transthoracic (TTE) or transesophageal (TEE) echocardiography. This study aimed to evaluate the feasibility of a diagnostic tool for thoracic cardiovascular thrombi according to the first experience with a new extended cardio-stroke protocol (Big 5—Jena eCS protocol) in acute stroke patients.

Methods
Retrospective analyses of the tomography scans database of the Jena University Hospital were performed. We included a total of 67 patients in the feasibility analyses, based on the evaluation of three outcomes.

Results
Primary outcome: the Big 5—Jena eCS protocol was able to detect thoracic cardiovascular thrombi in a total of 20 patients in different locations including the arch of the aorta, the aortic valve, the left atrium, the left atrial appendage, the left ventricle, and the pulmonary arteries. Secondary outcome: implementating the protocol did not result in a significant elevation of the radiation exposure compared to traditional protocols. Tertiary outcome: the new protocol identified seven cases that were considered negative by echocardiography.

Conclusion
The implementation of an extended cardio-stroke protocol is feasible, no significantly time-consuming, acquiring assessable imaging, and maintaining radiation exposure acceptable. The Big 5—Jena eCS protocol was also able to detect some thrombi not reported by TTE or TEE; however, due to our data’s explorative character, a conclusive comparison with cardiac ultrasound is not possible. A prospective pilot study and clinical trials should be conducted to assess the diagnostic accuracy of this protocol compared to echocardiography and determine the potential impact on diagnostic and treatment decisions.
Hyaluronic acid injections in post-enucleation or evisceration socket syndrome: a case series
Authors: Migliardi Renata , Modugno Alessandra , Chirico Fabrizio , Zerbinati Nicola , Nicoletti Giovanni Francesco , Lo Giudice Giorgio , Rauso Raffaele 
Published: August 2021

Abstract
Background
One of the primary goals of enucleation and evisceration surgery is the restoration of an adequate orbital volume through the use of appropriately sized alloplastic or autogenous tissues. In patients inadequately treated, post-enucleation or evisceration socket syndrome occurs. Fillers are an ideal alternative for eyelid and eyebrow arcade volume enhancement since their injection is easily performed in an outpatient setting avoiding several complications. The aim of this study is to report the use of hyaluronic acid (HA) fillers to treat volume deficits of the upper and lower eyelids, projecting the brow arcade and reducing the asymmetry.

Methods
Thirteen patients (2 male, 11 female, mean age 32.7 years) were treated from June 2012 to May 2020. Non-surgical treatment by HA filler injection for aesthetic rehabilitation of deep superior sulcus, inferior tear trough deformity, and scleral show was performed.

Results
No complications as orbital-ache and/or vasovagal response were reported during the injections. Minor complications such as light swelling at the site of injection, self-resolved within 2 days, were recorded. Stable results were observed at follow-ups. In two cases, two successive treatments were required at 3 and 6 years from the first injection.

Conclusions
Hyaluronic acid fillers offer a versatile and safe method for replacing soft tissue lost from the upper eyelid/brow complex in cases of post-enucleation or evisceration socket syndrome.
Level of evidence: Level IV, therapeutic study.
Multilayered regulation of proteome stoichiometry
Authors: Ishikawa Koji 
Published: August 2021

AbstractCellular systems depend on multiprotein complexes whose functionalities require defined stoichiometries of subunit proteins. Proper stoichiometry is achieved by controlling the amount of protein synthesis and degradation even in the presence of genetic perturbations caused by changes in gene dosage. As a consequence of increased gene copy number, excess subunits unassembled into the complex are synthesized and rapidly degraded by the ubiquitin–proteasome system. This mechanism, called protein-level dosage compensation, is widely observed not only under such perturbed conditions but also in unperturbed physiological cells. Recent studies have shown that recognition of unassembled subunits and their selective degradation are intricately regulated. This review summarizes the nature, strategies, and increasing complexity of protein-level dosage compensation and discusses possible mechanisms for controlling proteome stoichiometry in multiple layers of biological processes.
Spin dynamic response to a time dependent field
Authors: Bevilacqua Giuseppe , Biancalana Valerio , Dancheva Yordanka , Fregosi Alessandro , Vigilante Antonio 
Published: August 2021

AbstractThe dynamic response of a parametric system constituted by a spin precessing in a time dependent magnetic field is studied by means of a perturbative approach that unveils unexpected features, and is then experimentally validated. The first-order analysis puts in evidence different regimes: beside a tailorable low-pass-filter behaviour, a band-pass response with interesting potential applications emerges. Extending the analysis to the second perturbation order permits to study the response to generically oriented fields and to characterize several non-linear features in the behaviour of such kind of systems.
Entwicklung von Qualitätsstandards für Patient*innen mit axialer Spondyloarthritis zum Einsatz in Deutschland
Authors: Kiltz U. , Buschhorn-Milberger V. , Albrecht K. , Lakomek H.-J. , Lorenz H.-M. , Rudwaleit M. , Schneider M. , Schulze-Koops H. , Baraliakos X. , Behrens F. , Brandt-Jürgens J. , Haibel H. , Hammel L. , Karberg K. , Kellner H. , Krause D. , Lange U. , Märker-Herrmann E. , Poddubnyy D. , Sieper J. , Syrbe U. , Braun J. 
Published: August 2021

ZusammenfassungQualitätsstandards (QS) sind messbare Konstrukte, die helfen sollen, Versorgungslücken quantitativ zu erfassen, um langfristig die Versorgungsqualität zu verbessern. Die Assessment of SpondyloArthritis International Society (ASAS) hat kürzlich erstmals internationale QS für das Management von Patient*innen mit axialer Spondyloarthritis (axSpA) konsentiert und veröffentlicht. Die Deutsche Gesellschaft für Rheumatologie (DGRh) hat daraufhin beschlossen, diese Standards durch eine Gruppe von Expert*innen aus unterschiedlichen Versorgungsbereichen zu übersetzen, zu prüfen und ggf. zu übernehmen. Vor diesem Hintergrund wurden erstmals nationale QS für das Management von Patient*innen mit axSpA für Deutschland entwickelt. Hierbei wurde v. a. auf Machbarkeit und Praxisrelevanz geachtet. Letztlich wurden 9 QS definiert, mit denen die Qualität der Versorgung in Deutschland gemessen und verbessert werden kann bzw. soll.
Variation partitioning in double-constrained multivariate analyses: linking communities, environment, space, functional traits, and ecological niches
Authors: Sîrbu Ioan , Benedek Ana Maria , Sîrbu Monica 
Published: August 2021

AbstractConstrained multivariate analysis is a common tool for linking ecological communities to environment. The follow-up is the development of the double-constrained correspondence analysis (dc-CA), integrating traits as species-related predictors. Further, methods have been proposed to integrate information on phylogenetic relationships and space variability. We expand this framework, proposing a dc-CA-based algorithm for decomposing variation in community structure and testing the simple and conditional effects of four sets of predictors: environment characteristics and space configuration as predictors related to sites, while traits and niche (dis)similarities as species-related predictors. In our approach, ecological niches differ from traits in that the latter are distinguished by and characterize the individual level, while niches are measured on the species level, and when compared, they are characteristics of communities and should be used as separate predictors. The novelties of this approach are the introduction of new niche parameters, niche dissimilarities, synthetic niche-based diversity which we related to environmental features, the development of an algorithm for the full variation decomposition and testing of the community–environment–niche–traits–space (CENTS) space by dc-CAs with and without covariates, and new types of diagrams for the results. Applying these methods to a dataset on freshwater mollusks, we learned that niche predictors may be as important as traits in explaining community structure and are not redundant, overweighting the environmental and spatial predictors. Our algorithm opens new pathways for developing integrative methods linking life, environment, and other predictors, both in theoretical and practical applications, including assessment of human impact on habitats and ecological systems.
Chemical analysis reveals sex differences in the preen gland secretion of breeding Blue Tits
Authors: Caspers Barbara A. , Marfull Reinaldo , Dannenhaus Tim , Komdeur Jan , Korsten Peter 
Published: August 2021

AbstractAcoustic and visual signals are well known to play important roles in social communication in birds. Growing evidence suggests that many bird species, including species of songbirds, additionally have a well-developed sense of smell. However, we are still at the beginning of understanding the potential importance of chemical communication in the social lives of birds, for example in mate choice. The secretion of the preen gland may be an important contributor to the chemical phenotype of birds. Here, we report on a first characterisation of the chemical composition of the preen gland secretion of the Blue Tit (Cyanistes caeruleus), a common songbird which is an often used model species in animal behaviour and ecology, in particular also in studies of sexual selection and (extra-pair) mate choice. We found sex differences in the composition of the preen gland secretion in breeding Blue Tits. Females further tended to have a larger number of putative compounds in their secretions compared to males. We briefly discuss the possible implications of these findings and speculate that the chemical composition of the preen gland secretion may be a sexually selected trait in Blue Tits. Our preliminary findings warrant follow-up research into the patterns of within- and among individual variation in the chemical composition of the preen gland secretion as well as the identification of the main chemical compounds involved.