bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carotid artery stenting assisted with intravascular ultrasonography for isolated spontaneous common carotid artery dissection
Authors: Sanada Takahiro , Wada Hajime , Sato Hirotaka , Shirai Wakako , Kinoshita Manabu , Tokumitsu Naoki 
Published: June 2021

Abstract
Isolated spontaneous common carotid artery (CCA) dissection is extremely rare. Moreover, only a few case reports for isolated spontaneous CCA dissection treated with carotid artery stenting (CAS) can be found so far. Here, the authors report a case where intravascular ultrasonography (IVUS) provided valuable information about lesion evaluation, stent selection and stent placement during CAS for isolated CCA dissection. A 69-year-old male was diagnosed with an isolated spontaneous left CCA dissection. CAS assisted with IVUS was performed to prevent further dissection and cerebral infarction recurrence. To the best of our knowledge, this is the first case report of an isolated spontaneous CCA dissection treated with CAS assisted by IVUS. CAS assisted by IVUS may be an effective treatment option to prevent intraoperative complications and further stroke recurrence for isolated spontaneous CCA dissection.
The first annotated corpus of historical Basque
Authors: Estarrona Ainara , Etxeberria Izaskun , Soraluze Ander , Etxepare Ricardo , Padilla-Moyano Manuel 
Published: June 2021

Abstract
This article presents the elaboration of a morphosyntactically annotated diachronic corpus of Basque, and the first results obtained in the processing of historical varieties of this language with computational techniques. The corpus size is around one million words, expanding from the 15th to the mid-18th century and encompassing the most significant written production in all historical dialects. Morphosyntactic tagging allows for systematic searches at different levels of complexity; additionally, a rich set of metadata enables searches based on sociohistorical criteria too. This is not only the first tagged corpus of historical Basque but also a means to improve language processing tools by analyzing historical varieties more or less distant from the present-day standard language. Moreover, this project aims to set a model for further works in the historical corpora of Basque and inform similar projects on other languages.
FINER: enhancing the prediction of tissue-specific functions of isoforms by refining isoform interaction networks
Authors: Chen Hao , Shaw Dipan , Bu Dongbo , Jiang Tao 
Published: June 2021

Abstract
Annotating the functions of gene products is a mainstay in biology. A variety of databases have been established to record functional knowledge at the gene level. However, functional annotations at the isoform resolution are in great demand in many biological applications. Although critical information in biological processes such as protein–protein interactions (PPIs) is often used to study gene functions, it does not directly help differentiate the functions of isoforms, as the ‘proteins’ in the existing PPIs generally refer to ‘genes’. On the other hand, the prediction of isoform functions and prediction of isoform–isoform interactions, though inherently intertwined, have so far been treated as independent computational problems in the literature. Here, we present FINER, a unified framework to jointly predict isoform functions and refine PPIs from the gene level to the isoform level, enabling both tasks to benefit from each other. Extensive computational experiments on human tissue-specific data demonstrate that FINER is able to gain at least 5.16% in AUC and 15.1% in AUPRC for functional prediction across multiple tissues by refining noisy PPIs, resulting in significant improvement over the state-of-the-art methods. Some in-depth analyses reveal consistency between FINER’s predictions and the tissue specificity as well as subcellular localization of isoforms.
Clinical characterization of adult medulloblastoma and the effect of first-line therapies on outcome; The MD Anderson Cancer Center experience
Authors: Majd Nazanin K , Mastall Maximilan , Lin Heather , Dibaj Seyede Shiva , Hess Kenneth R , Yuan Ying , Garcia Manuela Martin-Bejarano , Fuller Gregory N , Alfaro Kristin D , Gule-Monroe Maria K , Huse Jason T , Khatua Soumen , Rao Ganesh , Sandberg David I , Wefel Jeffrey S , Yeboa Debra N , Paulino Arnold C , McGovern Susan L , Zaky Wafik , Mahajan Anita , Suki Dima , Weathers Shiao-Pei , Harriso Rebecca A , De Groo John F , Puduvalli Vinay K , Penas-Prado Marta 
Published: June 2021

AbstractBackgroundAdult medulloblastoma (MB) is rare, and management guidelines are largely based on pediatric clinical trials and retrospective series. Limited data exist with respect to clinical characteristics, prognostic factors, and outcomes based on first-line treatments.MethodsTwo hundred adults with MB seen at a single institution from January 1978 to April 2017 were identified and followed for a median of 8.4 y (7.1, 10.3).ResultsPatient’s median age at diagnosis was 29 y (18, 63). One hundred eleven (55.5%) were standard-risk, 59 (29.5%) were high-risk, and 30 (15.0%) were indeterminate. Most received post-operative radiation (RT) (184 [92.0%]), and 105 (52.5%) received first-line chemotherapy. Median overall survival (OS) was 8.8 y (7.2, 12.2) and median progression-free survival (PFS) was 6.6 y (4.9, 11.2). High-risk patients had inferior OS (Hazard ratio [HR] = 2.5 [1.5, 4.2], P = .0006) and PFS (HR = 2.3 [1.3, 3.9], P = .002) compared to standard-risk patients. Age, sex, and metastatic disease were not associated with survival. After adjusting for risk status, those who received RT plus adjuvant chemotherapy had superior PFS compared to RT plus neoadjuvant chemotherapy [HR = 0.46 (0.22, 0.95), P = .0357]. Within a subgroup for whom detailed clinical data were available, those who received RT plus adjuvant chemotherapy had improved PFS compared to RT only [HR = 0.24 (0.074–0.76), P = .016]. The substitution of cisplatin for carboplatin and the elimination of vincristine did not negatively affect outcomes.ConclusionThis is the largest single-institution retrospective study of adult MB to our knowledge and identifies standard-risk status, first-line RT and adjuvant chemotherapy as factors associated with improved outcomes.
Relational Autonomy
Authors: Mackenzie Catriona 
Published: June 2021

Abstract
This chapter offers an account of central issues and themes in feminist philosophical reflections on relational autonomy. Relational theories of autonomy explicate the social dimensions of personal autonomy, as well as the ways its development and exercise can be impaired by social oppression. The chapter outlines debates between internalist and externalist, and procedural and substantive theories of relational autonomy, including discussion of important contributions to these debates over the last two decades. It proposes that a multidimensional analysis of autonomy offers a possible resolution to these debates. Specifically, the chapter argues for the importance of distinguishing self-determination, self-governance, and self-authorization as distinct although causally interacting dimensions of relational autonomy. The advantage of a multidimensional analysis of autonomy is that it does justice to the complexity of the concept, while also clarifying the multifarious ways in which social oppression can impair autonomy.
Queer Theory
Authors: Salamon Gayle 
Published: June 2021

Abstract
This chapter offers an account of central issues and themes in queer theory, with particular attention to the challenges it has posed to the concepts of normativity, identity, and the category of “woman.” It explores queer theory’s emergence from lesbian and gay studies, and considers its relation to feminist philosophy and trans theory. The chapter outlines the founding contributions of Judith Butler and Eve Kosofsky Sedgwick, along with several other influential queer theorists, and traces the concept of heteronormativity from its central place in queer theory’s earliest works to more recent reconsiderations.
Rose (Rosa hybrida) Ethylene Responsive Factor 3 Promotes Rose Flower Senescence via Direct Activation of the Abscisic Acid Synthesis–Related 9-CIS-EPOXYCAROTENOID DIOXYGENASE Gene
Authors: Luo Jing , Chen Sijia , Cao Shenghai , Zhang Tong , Li Ruirui , Chan Zhu Long , Wang Caiyun 
Published: June 2021

Abstract
During plant senescence, energy and nutrients are transferred to young leaves, fruits or seeds. However, senescence reduces flower quality, which leads to huge economic losses in flower production. Ethylene is an important factor affecting the quality of cut roses during transportation and storage. Ethylene-responsive factors (ERFs) are key nodes in ethylene signaling, but the molecular mechanism underlying ERFs regulated flower senescence is not well understood. We addressed this issue in the present study by focusing on RhERF3 from Rosa hybrida, an ERF identified in a previous transcriptome analysis of ethylene-treated rose flowers. Expression of RhERF3 was strongly induced by ethylene during rose flower senescence. Transient silencing of RhERF3 delayed flower senescence, whereas overexpression (OE) accelerated the process. RNA sequencing analysis of RhERF3 OE and pSuper vector control samples identified 13,214 differentially expressed genes that were mostly related to metabolic process and plant hormone signal transduction. Transient activation and yeast one-hybrid assays demonstrated that RhERF3 directly bound the promoter of the 9-cis-epoxycarotenoid dioxygenase (RhNCED1) gene and activated gene expression. Thus, a RhERF3/RhNCED1 axis accelerates rose flower senescence.
Triacylglycerol remodeling in Physaria fendleri indicates oil accumulation is dynamic and not a metabolic endpoint
Authors: Bhandari Sajina , Bates Philip D. 
Published: June 2021

Abstract
Oilseed plants accumulate triacylglycerol (TAG) up to 80% of seed weight with the TAG fatty acid composition determining its nutritional value or use in the biofuel or chemical industries. Two major pathways for production of diacylglycerol (DAG), the immediate precursor to TAG, have been identified in plants: de novo DAG synthesis and conversion of the membrane lipid phosphatidylcholine (PC) to DAG, with each pathway producing distinct TAG compositions. However, neither pathway fits with previous biochemical and transcriptomic results from developing Physaria fendleri seeds for accumulation of TAG containing &gt;60% lesquerolic acid (an unusual 20 carbon hydroxylated fatty acid), which accumulates at only the sn-1 and sn-3 positions of TAG. Isotopic tracing of developing P. fendleri seed lipid metabolism identified that PC-derived DAG is utilized to initially produce TAG with only one lesquerolic acid. Subsequently a nonhydroxylated fatty acid is removed from TAG (transiently reproducing DAG) and a second lesquerolic acid is incorporated. Thus, a dynamic TAG remodeling process involving anabolic and catabolic reactions controls the final TAG fatty acid composition. Reinterpretation of P. fendleri transcriptomic data identified potential genes involved in TAG remodeling that could provide a new approach for oilseed engineering by altering oil fatty acid composition after initial TAG synthesis; and the comparison of current results to that of related Brassicaceae species in the literature suggests the possibility of TAG remodeling involved in incorporation of very long-chain fatty acids into the TAG sn-1 position in various plants.
The vulnerable in time of pandemic: toward a preferential option for the vulnerable and marginalized
Authors: Corpuz Jeff Clyde G 
Published: June 2021

Abstract
The disproportionate impact of the pandemic on certain populations has highlighted numerous inequities and injustices in our world. In considering the most vulnerable during the COVID-19 pandemic, an inclusive approach is not only a humanitarian approach but also a global public health imperative. The rights of the most vulnerable groups, such as women, youth, indigenous people and persons with disabilities and with co-morbidity, among others need to be protected.
From anxious loneliness to meditation: a mental health self-care strategy to cope with the COVID-19 pandemic
Authors: Deguma Melona C , Lumayag Charisma G , Villaganas Mary Anne C , Delos Reyes Niña Rozanne T , Deguma Jabin J 
Published: June 2021

Abstract
It has been a matter of public knowledge that physical and mental health are intertwining concerns. With a high association between the individuals’ experience of the novel Corona Virus Disease in 2019 (COVID-19) and their psychological distress, mental health experts recognized mental health as a coterminous public health concern with the COVID-19 pandemic. In this journal, a systematic review study pointed out that mental health is the most affected issue concerning implementing governments worldwide adopted policies like staying at home, social distancing and ‘lockdown’ measures. However, we argue that these containment measures could be non-detrimental to mental health when one transforms his or her experience of anxious loneliness into an avenue of practicing meditation as a strategy of mental health self-care.
The Covid-19 pandemic and its concomitant benefits: improved hygiene habits
Authors: Macaraan Willard Enrique R 
Published: June 2021

Abstract
In an editorial, the editor has explored how state response to the pandemic has collateral damages not only in the public health in general but also in economy and education. Ironically, it also shows that the adjustments and adaptations in peoples’ behavior have resulted in improved habits in personal hygiene and self-care. Not all is bad though as people have (re)learned the basic value of handwashing and preventive measures to avoid any diseases and spread of germs. In the long run, this is going to be beneficial to prevent any repeat of the pandemic of this magnitude.
The environment in the post-pandemic scenario: sustaining the gains
Authors: Macaraan Willard Enrique R 
Published: June 2021

Abstract
In a recent correspondence, the authors noted how temporary the experience of improved air quality in the Philippines during the pandemic. They argued that beyond the crafting of policies and guidelines, there must be a solid attitudinal change in the way a person looks, behaves and lives with his/her surroundings. I support that stance and would further argue that community-based approaches can reinforce that desired change and outcome especially in remote villages and communities where group/communal identity is far more normative than individuated identification.
EVALUATION OF ANNUAL RADIATION EXPOSURE OF STAFF IN A CARDIAC CATHETERIZATION DEPARTMENT IN SAUDI ARABIA
Authors: Sulieman A , Mayhoub F , Ibrahim H Salah , Omer H , Alkhorayef M , Abolaban Fouad A , Al-Mohammed H , Khandaker M U , Bradley D A 
Published: June 2021

Abstract
The objective of this study is to estimate the annual effective dose for cardiologists and nurses by measuring Hp(10) and Hp(0.07) during cardiac catheterization procedures. A total of 16 staffs members were working in interventional cardiology during 1 year at a tertiary hospital. The occupational dose was measured using calibrated thermo-luminescent dosemeters (TLD-100, LiF:Mg,Ti). The overall mean and range of the annual Hp(10) and Hp(0.07) (mSv) for cardiologists were 3.7 (0.13–14.5) and 3.2 (0.21–14.7), respectively. Cardiologists were frequently exposed to higher doses compared with nurses and technologists. The exposure showed wide variations, which depend on occupation and workload. Staff is adhered to radiation protection guidelines regarding shielding the trunk, thyroid shield, thus appropriately protected. Lens dose measurement is recommended to ensure that dose limit is not exceeded.
AI meets narratives: the state and future of research on expectation formation in economics and sociology
Authors: Svetlova Ekaterina 
Published: June 2021

AbstractThis article presents contemporary concepts of economic beliefs in economics and sociology: (a) behavioural accounts; (b) learning; (c) narrative approaches; and (d) Science and Technology Studies-inflected integrative accounts. The review argues that cutting-edge research on expectations in both disciplines has paid insufficient attention to the fact that human agents are supported and partly substituted by modern technology while forming their beliefs. Thus, this article discusses how models, algorithms and artificial intelligence co-determine and profoundly change the theoretical and empirical understanding of expectation formation, and outlines a joint research agenda for studying economic expectations.
Effects of moisture and temperature on Salmonella survivability in beef tallow, white grease, and chicken rendered fat
Authors: Molitor April , Yucel Umut , Vipham Jessie , Jones Cassandra , Trinetta Valentina 
Published: June 2021

Abstract
High moisture levels introduced to fats after the rendering process can lead to Salmonella presence and growth. Limited research on strategies to eliminate pathogens in these environments are available. Rendered fat characteristics, such as water activity and fatty acids composition, may contribute to Salmonella survivability. The purpose of this research was to evaluate the effects of moisture levels (0%, 0.5%, 1%, and 3%), storage temperatures (48 and 76 ˚C), and fat characteristics on the growth and survival of Salmonella in beef tallow, white grease and poultry fat samples. Samples were inoculated with a high (~108 CFU/mL) and a low (~105 CFU/mL) Salmonella cocktail (S. Senftenberg, S. Newport, S. Thompson and S. Infantis). Samples were stored for up to 5 days at 48 and 76 ºC. Remaining population was evaluated daily with and without enrichment step. Death rates were calculated using Weibull model for each temperature and moisture level. Only temperature had an effect (P &lt; 0.05) on Salmonella inactivation, while no effect between moisture and/or inoculum level were observed. When all products were challenged at 76 ˚C, counts were below detectable limits after 6 hours. At 48˚C a progressive decline in Salmonella population was observed within 3 days for both beef tallow and white grease when high inoculum was used for the challenge study. Salmonella was below detectable limit within 4 days for both fat types when a low inoculum was instead applied. This research identified the effect of moisture and temperature in rendered fat samples contaminated with Salmonella and underlined the need to use time–moisture–temperature data to minimize microbial growth during transportation and storage.
Poplar PsnICE1 enhances cold tolerance by binding to different cis-acting elements to improve reactive oxygen species-scavenging capability
Authors: Wang Yan-Min , Zhang Yi-Ming , Zhang Xin , Zhao Xin , Zhang Yu , Wang Chao , Wang Yu-Cheng , Wang Liu-Qiang 
Published: June 2021

Abstract
Low temperature is a major stress that severely affects plant growth and development. Inducer of CBF expression 1 (ICE1) plays a key role in plant cold tolerance by regulating the expression of cold stress-responsive genes. In the present study, we characterized the function and underlying regulatory mechanism of PsnICE1 from Xiaohei poplar (Populus simonii × Populus nigra). PsnICE1 was significantly induced in response to cold stress in the roots, stems and leaves. PsnICE1 proteins were found to localize to the nucleus and exert transactivation activity via their N-terminal transactivation domain. Compared with non-transgenic poplar, transgenic poplar overexpressing PsnICE1 showed substantially enhanced tolerance to cold stress, with higher survival rates and antioxidant enzyme activity levels and reduced reactive oxygen species (ROS) accumulation. In contrast, plants with RNA inhibition-mediated silencing of PsnICE1 showed the opposite phenotype. PsnICE1 can bind to H-box element and abscisic acid-responsive element (ABRE), and more importantly, it mainly binds to IBS1 (a newly discovered cis-acting element) and E-box elements to regulate stress-related genes involved in ROS scavenging. Overall, these results indicated that PsnICE1 functions as a positive regulator of cold tolerance and serves as a potential candidate gene for plant cold tolerance improvement via molecular breeding.
The Use of Eponyms in Education: Ethics, History, and Constructivism
Authors: Barger John Bradley 
Published: June 2021

The use of eponyms (personal names used as nouns) in anatomy and medicine has a long and complicated history. Eponyms have been gradually removed from most curricula in favor of descriptive terms as specified in the Terminologica Anatomica. However, a number of eponyms remain in current use, usually given as an alternate term after the preferred term has been defined. I argue that the use of eponyms in normal anatomy and medical curricula should be completely removed. I define three primary arguments for the removal of eponyms. 1. Some eponyms honor scientists who made discoveries through unethical means, notable Nazi scientists in the Third Reich. 2. Many eponyms originated in 18th‐ and 19th‐ century Europe, giving the impression that only male European scientists contributed to the history of medicine. 3. From a pedagogical perspective, eponyms reinforce the misconception that “anatomy is pure memorization.” If we value constructivism and long‐term knowledge retention, systematic names are more valuable to the novice student than the apparently arbitrary eponyms applied to medical and anatomical entities. All of the arguments outlined above are only relevant to the perspective of the anatomy/medical educators. If one is teaching ethics or history of medicine, then the use of eponyms is a great way to highlight the ethical and historical debates necessary to those courses.Support or Funding InformationNoneThis abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
Anatomy Observational Outreach: a Multimodal Activity to Enhance Anatomical Education in Undergraduate Students
Authors: Gonzalez‐Sola Maryvi , Hyder Aneesah , Rosario Martin G 
Published: June 2021

Undergraduate students often have difficulty relating Anatomy and Physiology (A&P) course contents to their future careers, leading to a lack of interest and degree completion. The purpose of the Anatomy Observational Outreach (AOO) was to raise students' interest in STEM and Allied Health fields, help students make the connection and application between the information presented in A&P labs and real‐world activities, as well as to effectively encourage students to pursue graduate degrees in Allied Health Careers. The outreach consisted of 100 undergraduate A&P students from Texas Woman's University's biology, nursing, kinesiology, health studies, physical therapy, and occupational therapy departments. The methodology consisted of a 15‐minute orientation, graduate student panel Q&A session, 30‐minute cadaver and organ prosections, 30‐minute Anatomage table demonstration, anatomical models, and x‐rays. To measure the impact of the outreach, students were given identical 10‐question pretests and post‐tests, of which each question accounted for 1 point. The results of the students' post‐tests demonstrated a 98% increase in anatomical knowledge and an 84% increase in interest in graduate degrees in STEM and Allied Health fields. Moreover, 81% of students felt all of the activities and tools were useful, while 19% concluded the cadaver prosections were the strongest sole educational aids. It was also found that of the 100 students in attendance, 55% were ethnic minorities and 90% were gender minorities. We conclude that the AOO yielded distinguished results in the depth, retention, and application of A&P knowledge, along with increased interest, excitement, and motivation for pursuing tertiary STEM and Allied Health degrees among undergraduates. The future goal for the AOO is to establish a biannual “Anatomy Week” to encourage and inspire students and minority scholars to further their tertiary education in STEM and Allied Health fields.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.