bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entrepreneurship education in Indonesian higher education: mapping literature from the Country’s perspective
Authors: Amalia Ria Tristya , von Korflesch Harald F. O. 
Published: July 2021

AbstractEntrepreneurship education has become an important and fast-growing research area contributing to understanding and acknowledging global and national trends and developing future educational policies and actions. From the country’s perspective, the development of entrepreneurship education in Indonesia is relatively recent. This circumstance is reflected by the minimal amount of research in English language articles published in prominent journals, the uneven provision programs, and the lack of modern practices in teaching and learning entrepreneurship in higher education across the country. Due to those rationales, this study aims to serve as an initial proposition by mapping some current states concerning Indonesian entrepreneurship education programs’ provision, its common learning practices within the higher education context, and its relation to students’ entrepreneurial competencies, characteristics, and Indonesian entrepreneurs’ issues on entrepreneurship education. By using mapping literature methodology, this study has identified and analyzed 31 articles concerning Indonesian entrepreneurship in higher education, searched through electronic database and international and national universities publications for the last ten-year period (2010–2019). The results showed that major entrepreneurship education program provisions and implementation of contemporary entrepreneurship course contents and teaching methods in Indonesia are centralized in Java Island—Indonesia. Another notable finding is mentoring, the most recent and emerging entrepreneurial type in Indonesia to support more students’ learning engagement and independence, or education through entrepreneurship. The study’s findings could inform the Indonesian government, educators, researchers, and educational policymakers concerning the current circumstances of Indonesian entrepreneurship education and how to improve them in the future.
Surveillance practices and air-sampling strategies to address healthcare-associated invasive mold infections in Society for Healthcare Epidemiology of America (SHEA) Research Network hospitals—United States, 2020
Authors: Gold Jeremy A. W. , Jackson Brendan R. , Glowicz Janet , Mead Kenneth R. , Beer Karlyn D. 
Published: July 2021

AbstractWith this survey, we investigated healthcare-associated invasive mold infection (HA-IMI) surveillance and air sampling practices in US acute-care hospitals. More than half of surveyed facilities performed HA-IMI surveillance and air sampling. HA-IMI surveillance was more commonly performed in academic versus nonacademic facilities. HA-IMI case definitions and sampling strategies varied widely among respondents.
How we do it: impacted oesophageal foreign body removal using a dilatation balloon
Authors: Chakravarty P D , Kunanandam T , Walker G 
Published: July 2021

AbstractBackgroundIngested foreign bodies are a common presentation to paediatric ENT services. Depending on the site, these are usually managed with flexible or rigid oesophagoscopy and retrieval. This paper presents a novel technique for removing a hollow foreign body that could not be removed using conventional means.Method and resultsAfter rigid and flexible approaches failed, a guidewire was passed through the foreign body under fluoroscopic guidance and a dilatation balloon passed through the lumen of the object. Inflating the balloon allowed dilatation of the inflamed mucosa above and below the object, facilitating straightforward removal under traction.ConclusionThis is a novel and reproducible technique that uses equipment readily available in tertiary referral centres. Employed in this context, the technique enabled removal of an impacted object surrounded by granulation tissue, and would be appropriate for other objects with a lumen.
Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose–response relationship in children and adolescents
Authors: Marques-Feixa Laia , Palma-Gudiel Helena , Romero Soledad , Moya-Higueras Jorge , Rapado-Castro Marta , Castro-Quintas Águeda , Zorrilla Iñaki , José Muñoz María , Ramírez Maite , Mayoral María , Mas Ariadna , José Lobato María , Blasco-Fontecilla Hilario , Fañanás Lourdes ,   EPI-Young Stress GROUP
Published: July 2021

AbstractBackgroundThis study investigates the impact of childhood maltreatment (CM) on hypothalamic–pituitary–adrenal (HPA)-axis functioning and on anxiety perception. Moreover, the influence of CM severity and frequency was also explored.MethodsIn total, 187 participants aged 7–17 were assessed for CM history using validated questionnaires and ad hoc interviews to be classified according to the criteria of the Tool for Assessing the Severity of Situations in which Children are Vulnerable (TASSCV). Psychopathology was ascertained using the K-SADS-PL5. To assess HPA-axis functioning, salivary cortisol samples were collected throughout a normal day and during an acute psychosocial stressor, the Trier Social Stress Test for children (TSST-C). Subjective anxiety was evaluated using STAI/-C.ResultsYouth with a CM history had higher overall diurnal cortisol levels (p = 0.001), blunted cortisol response to acute psychosocial stress (p = 0.002) and greater perceived anxiety (p = 0.003), than those without CM. Specifically, participants exposed to moderate/severe or often/frequent CM showed the greater diurnal cortisol output (pseverity = 0.002; pfrequency = 0.003), and blunted cortisol response during the TSST-C (pseverity = 0.006; pfrequency = 0.008). Meanwhile, youth with low CM severity/frequency exhibited a similar cortisol response to those without CM. However, perceived anxiety was higher in those exposed to CM (p < 0.001), regardless of its severity/frequency.ConclusionsDisturbances in HPA-axis functioning are already evident early after CM exposure, while psychological and physiological responses to an acute stressor are dissociated in youth exposed to CM. The dose–response relationship described in this paper highlights the need to comprehensively evaluate CM so that vulnerable children can be identified and assigned to proper interventions.
The birth of oppida: small towns in Hungary in the Angevin period
Authors: Szende Katalin 
Published: July 2021

AbstractThis article revisits the origins of small towns in medieval Hungary from the perspective of their owners and seigneurs. The fourteenth-century development of small towns on the estates of private landowners resulted from the coincidence of several factors. Among these, the article considers the intersection of royal and private interests. The aristocrats’ concern to endow their estate centres with privileges or attract new settlers to their lands was dependent on royal approval; likewise, the right to hold annual fairs had to be granted by the kings, and one had to be a loyal retainer to be worthy of these grants. The royal model of supporting the mendicant orders, which were gaining ground in Hungary from the thirteenth century onwards, added a further dimension to the overlords’ development strategies. This shows that royal influence, directly or indirectly, had a major impact on the development of towns on private lands in the Angevin period (1301–87).
Vertical Propagation of Coseismic Ionospheric Disturbances Associated With the Foreshock of the Tohoku Earthquake Observed Using HF Doppler Sounding
Authors: Nakata H. , Takaboshi K. , Takano T. , Tomizawa I. 
Published: July 2021

AbstractThe vertical propagation of coseismic ionospheric disturbances (CIDs) associated with the foreshock of the Tohoku earthquake was examined using an HF Doppler sounding system. The sounding system used in this study received radio waves at four different frequencies (5.006, 6.055, 8.006, and 9.595 MHz), indicating that ionospheric disturbances can be observed at up to four altitudes. CIDs were observed at these four frequencies in association with the foreshock of the Tohoku earthquake. From the propagation speed of the coseismic disturbances, it is assumed that the ground motion caused by the Rayleigh wave propagating from the epicenter generates the acoustic mode wave propagating upward, causing the neutral atmospheric particles to move vertically. To examine the characteristics of the acoustic wave, we determined the ratio of the vertical speed of the neutral particles to that of the ground motion observed by a seismometer. The vertical profiles of the ratio are roughly explained in terms of the characteristics of the acoustic mode wave resulting from the ground motion. However, the absolute values of the ratio are smaller than the theoretical ratio estimated by the atmospheric mass density and the attenuation model considering the viscosity, thermal conductivity, and relaxation losses. This result implies that the CIDs in this event may be affected by the nonlinear behavior of the acoustic mode wave.
Observations of Multiple Internal Wave Packets in a Tidal River Plume
Authors: Rijnsburger Sabine , Flores Raúl P. , Pietrzak Julie D. , Lamb Kevin G. , Jones Nicole L. , Horner‐Devine Alexander R. , Souza Alejandro J. 
Published: July 2021

AbstractRemotely sensed images document the occurrence of multiple packets of internal solitary waves (ISWs) in the Rhine River plume at the same time. We use a combination of field observations, and non‐hydrostatic and hydrostatic modeling to understand the processes that lead to the generation and retention of multiple ISW packets within the Rhine plume. Previous numerical modeling shows that the tidal plume front is trapped in the mid‐field plume for more than one tidal cycle due to tidal straining and recirculation within the plume, resulting in the presence of multiple fronts in the near‐and mid‐field plume regions. In this work, we show how variations in the strength of these fronts can lead to the release of ISW packets. We conclude that the retention of the fronts in the mid‐field region of the plume and modulation in the strength of the fronts can explain the presence of multiple ISW packets. A frontal Froude number analysis shows that fronts generated during the previous ebb tide can release ISWs in addition to the newly released tidal plume front.
Lawn Irrigation Contributions to Semi‐Arid Urban Baseflow Based on Water‐Stable Isotopes
Authors: Fillo Noelle K. , Bhaskar Aditi S. , Jefferson Anne J. 
Published: July 2021

AbstractIn semi‐arid cities, urbanization can lead to elevated baseflow during summer months. One potential source for additional water is lawn irrigation. We sought to quantify lawn irrigation contributions to summertime baseflow in Denver, Colorado, USA using water‐stable isotope (δ18O and δ2H) analysis of surface water, tap water, and precipitation. If lawn irrigation contributed significantly to baseflow, we predicted the isotopic composition of Denver's urban streams would more closely resemble local tap water than precipitation or streamflow from nearby grassland watersheds. We expected tap water to be distinctive due to local water providers importing source water from high elevations. Thirteen urban streams and two grassland streams were selected for sampling. None of the streams had high‐elevation headwaters or wastewater effluent, and the grassland streams did not receive irrigation. Tap water was sampled from five water service areas. The grassland streams flowed for 60% of summer 2019 while urban streams flowed for 90%–100% of the summer. An isotope mixing analysis using tap and precipitation end‐members over a two week antecedent period estimated that tap water contributed 65% ± 10%–93% ± 3% with a mean of 80% of urban baseflow on specific days in late summer. After taking contributions from infrastructure leakage into account, we estimated that lawn irrigation return flows made up 32% ± 10%–82% ± 21% of analyzed baseflow. Quantifying lawn irrigation contributions to urban baseflow provides a basis for understanding how changes to lawn irrigation efficiency would affect water yield in the Denver metropolitan area.
Instantaneous River‐Wide Water Surface Velocity Field Measurements at Centimeter Scales Using Infrared Quantitative Image Velocimetry
Authors: Schweitzer Seth A. , Cowen Edwin A. 
Published: July 2021

AbstractThis paper describes a novel velocimetry method we call infrared quantitative image velocimetry (IR‐QIV), that uses infrared (IR) images of thermal patterns advecting on water surfaces to calculate time‐resolved, instantaneous, two‐dimensional surface velocity fields. The method works day or night, and under most weather conditions, by tracking subtle thermal patterns on the water surface itself, which are present under most environmental conditions. No particle “seeding”, external light sources, or contact with the water are required. A form of remote sensing, IR‐QIV has significant advantages over visible‐light surface velocimetry methods such as particle image velocimetry (PIV). IR‐QIV allows calculation of instantaneous velocity at high spatial (centimeter scale) and temporal (1 Hz) resolutions over large areas (thousands of square meters), allowing metrics of turbulence to be calculated. Results from field measurements are presented, showing excellent agreement with nearby acoustic velocity measurements. We discuss best practices for IR image acquisition and processing based on our experience developing and working with IR‐QIV. Additionally, we discuss uncertainty analysis in velocimetry techniques using images collected at oblique viewing angles and pattern tracking in images containing gradients of intensity rather than discrete particles, as well as the deleterious effects of, and post‐processing ways to remove, camera fixed pattern noise, considerations relevant to all types of image‐based velocimetry. This approach can improve measurements from both fixed and mobile platforms such as unoccupied aerial systems (UASs).
Assessment of the Troposphere Products Derived From VMF Data Server With ERA5 and IGS Data Over China
Authors: Yang F. , Guo J. , Li J. , Zhang C. , Chen M. 
Published: July 2021

AbstractThe accurate modeling of zenith troposphere delay (ZTD) is significant for data processing of radio‐space‐geodetic techniques such as GNSS. The delay can be estimated by classic tropospheric models, which need the surface meteorological parameters. Considering the difficulty of obtaining meteorological data caused by various environment factors and the modeling errors in the models themselves, the above methods are often difficult to provide accurate products for GNSS data processing. Based on continuously updated NWP data from the European Centre for Medium‐Range Weather Forecasts (ECMWF), the Vienna Mapping Functions (VMF) data server provides a widely used data‐source for achieving ZTD with two types of models, that is, the discrete (VFM3) and empirical model (GPT3). Little or no accuracy comparison of these two models with different horizontal resolutions in GNSS community has been conducted over China. This study investigates the performance of the models in terms of calculation of ZHD, ZWD and ZTD, using the hourly values derived from the ERA5 and IGS data as references. The results show that the discrete model outperforms the empirical model and the increasing of horizontal resolution can improve the accuracy of the models. The performance of the empirical model in ZHD/ZWD calculation shows obvious influences of latitude changes and land‐sea differences, while the discrete model improves this phenomenon. The empirical distribution function and boxplot well indicate the accuracy differences of the two models in different seasons. We also found that the diurnal variation can only be detected in the ZHD calculation by the discrete model. The ZTD comparison gives the details of the two types of models at GNSS stations.
Reflection Full Waveform Inversion With Second‐Order Optimization Using the Adjoint‐State Method
Authors: Wang Tengfei , Cheng Jiubing , Geng Jianhua 
Published: July 2021

AbstractIn controlled‐source seismology, the standard full waveform inversion (FWI) can't reliably recover the macrovelocity structure in the deep part, if the surface seismic data lack of ultra‐long offsets and very low frequencies. Reformulating the FWI for pre‐critical reflections based on model scale separation leads to reflection waveform inversion (RWI), which aims to improve the reconstruction of low‐to‐intermediate model wavenumbers. However, the state‐of‐art RWI approaches rely on the gradient‐type optimization, resulting in slow convergence and inaccurate recovery of the deep macrovelocities. Therefore, we present a Hessian‐based second‐order optimization in the context of RWI. Based on the reflection Fréchet derivative with respect to the background model, the approximate Hessian and the point spread functions (PSFs) on toy models with two and three layers are constructed to gain physical insights about parameter coupling and spatial resolution at the scale of low‐to‐intermediate wavenumbers for finite‐offset and band‐limited data. The high‐velocity anomaly and checkerboard experiments demonstrate the benefit of incorporating the inverse approximate Hessian effect on the functional gradient. Accordingly, for large‐scale applications, we propose a matrix‐free Gauss‐Newton RWI approach, in which the Hessian‐vector product is formulated with the second‐order adjoint‐state method and an optimal updating direction is estimated in the nested inner loop to accelerate the convergence. A synthetic example and an application to the real data from East China Sea demonstrate that the proposed method can improve velocity model building and seismic imaging, especially for the deep targets.
ARVib suppresses growth of advanced prostate cancer via inhibition of androgen receptor signaling
Authors: Liu Chengfei , Armstrong Cameron M. , Ning Shu , Yang Joy C. , Lou Wei , Lombard Alan P. , Zhao Jinge , Wu Chun-Yi , Yu Aiming , Evans Christopher P. , Tepper Clifford G. , Li Pui-kai , Gao Allen C. 
Published: July 2021

AbstractTargeting androgen signaling with the second-generation anti-androgen drugs, such as enzalutamide (Enza), abiraterone (Abi), apalutamide (Apal), and darolutamide (Daro), is the mainstay for the treatment of castration-resistant prostate cancer (CRPC). While these treatments are effective initially, resistance occurs frequently. Continued expression of androgen receptor (AR) and its variants such as AR-V7 despite AR-targeted therapy contributes to treatment resistance and cancer progression in advanced CRPC patients. This highlights the need for new strategies blocking continued AR signaling. Here, we identify a novel AR/AR-V7 degrader (ARVib) and found that ARVib effectively degrades AR/AR-V7 protein and attenuates AR/AR-V7 downstream target gene expression in prostate cancer cells. Mechanistically, ARVib degrades AR/AR-V7 protein through the ubiquitin-proteasome pathway mediated by HSP70/STUB1 machinery modulation. ARVib suppresses HSP70 expression and promotes STUB1 nuclear translocation, where STUB1 binds to AR/AR-V7 and promotes its ubiquitination and degradation. ARVib significantly inhibits resistant prostate tumor growth and improves enzalutamide treatment in vitro and in vivo. These data suggest that ARVib has potential for development as an AR/AR-V7 degrader to treat resistant CRPC.
Evolution of rhizobial symbiosis islands through insertion sequence-mediated deletion and duplication
Authors: Arashida Haruka , Odake Haruka , Sugawara Masayuki , Noda Ryota , Kakizaki Kaori , Ohkubo Satoshi , Mitsui Hisayuki , Sato Shusei , Minamisawa Kiwamu 
Published: July 2021

Abstract
Symbiosis between organisms influences their evolution via adaptive changes in genome architectures. Immunity of soybean carrying the Rj2 allele is triggered by NopP (type III secretion system [T3SS]-dependent effector), encoded by symbiosis island A (SymA) in B. diazoefficiens USDA122. This immunity was overcome by many mutants with large SymA deletions that encompassed T3SS (rhc) and N2 fixation (nif) genes and were bounded by insertion sequence (IS) copies in direct orientation, indicating homologous recombination between ISs. Similar deletion events were observed in B. diazoefficiens USDA110 and B. japonicum J5. When we cultured a USDA122 strain with a marker gene sacB inserted into the rhc gene cluster, most sucrose-resistant mutants had deletions in nif/rhc gene clusters, similar to the mutants above. Some deletion mutants were unique to the sacB system and showed lower competitive nodulation capability, indicating that IS-mediated deletions occurred during free-living growth and the host plants selected the mutants. Among 63 natural bradyrhizobial isolates, 2 possessed long duplications (261–357 kb) harboring nif/rhc gene clusters between IS copies in direct orientation via homologous recombination. Therefore, the structures of symbiosis islands are in a state of flux via IS-mediated duplications and deletions during rhizobial saprophytic growth, and host plants select mutualistic variants from the resultant pools of rhizobial populations. Our results demonstrate that homologous recombination between direct IS copies provides a natural mechanism generating deletions and duplications on symbiosis islands.
Simulation of nanoparticles interacting with a cell membrane: probing the structural basis and potential biomedical application
Authors: Zhang Xiao , Ma Guanghui , Wei Wei 
Published: July 2021

AbstractNanoparticles (NPs), owing to their ultrasmall size, have been extensively researched for potential applications in biomedicine. During their delivery and functionalization within the organism, they frequently interact with cells. The resulting nano-bio interfaces between the NPs and cell membrane play an important role in dominating the physiological effects of NPs. Therefore, understanding how the properties of NPs affect their nano-bio interface interactions with the cell membrane is important. Compared to experimental and theoretical analyses, simulations can provide atomic-level accuracy regarding dynamic changes in structure, which can reveal the mechanisms of nano-bio interface interactions for feasible modulation. Thus, we reviewed the current advances in nano-bio interfaces from the perspective of simulations. This study will determine how the properties of NPs affect their interactions with cell membranes to provide insights for the design of NPs and summarize their corresponding biomedical applications.
Responsible use of negative research outcomes—accelerating the discovery and development of new antibiotics
Authors: Yu Helen 
Published: July 2021

AbstractFailure to share and make use of existing knowledge, particularly negative research outcomes, has been recognized as one of the key sources of waste and inefficiency in the drug discovery and development process. In the field of antibiotic research, providing a platform where negative outcomes could be shared to prevent the vicious cycle of duplicating costly studies that produce the same negative results would greatly de-risk and accelerate the development of new antibiotics. Providing a legally supported framework that recognizes negative outcomes as intellectual contributions, which can subsequently be translated into a revenue-sharing model, may lead to more openness and value creation in support of a sustainable and responsible transformation of research into socially and economically beneficial innovations.