bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infections and antibiotic therapy in patients after spine surgery in a 5-year follow-up study
Authors: Baranowska Joanna , Baranowska Alicja , Baranowski Paweł , Płusa Tadeusz , Białowąs Wojciech , Rybarczyk Marek , Konieczny Rafał 
Published: July 2021

IntroductionInfections after spinal surgery are sporadic and depend on the patient's condition and the type and extent of surgery. The incidence of surgical site infections in European centers ranges from 0% to 18%. The aim of the study was to determine the frequency of infections in patients after spinal surgery.Material and methodsThe analysis covered 6067 patients who underwent spinal surgery in the Department of Neuroorthopedics between 2015-2019, taking into account the number of microbiological tests and the number of detected infections, the number of surgical procedures and the rate of SSI infections, the number of readmissions and reoperations, and the use of antibiotics. The analysis was based on retrospective data of patients hospitalized in the analyzed period.ResultsThe number of operated patients remained at a similar level in the analyzed annual periods, from 1136 to 1269 patients, while the infection rate of the operated site ranged from 0,33% to 1,04%, and the percentage of infections was between 0,58% and 3,29 %. In turn, the analysis of reoperations performed due to infection of the operated site in 2018 and 2019 was 0,56% and 0,07%, respectively, which places the center in the leading position in the European ranking. During the analyzed five years, the use of antibiotics was reduced by 2/3.ConclusionsThe analysis of infections in patients after spinal surgery over a 5-year period showed that the SSI rate did not exceed 1,04%, which is comparable with data from recognized European centers. Infections caused by alarm pathogens have been detected occasionally.
ĐẶC ĐIỂM TỔN THƯƠNG ĐỘNG MẠCH VÀNH Ở BỆNH NHÂN NHỒI MÁU CƠ TIM CẤP ST CHÊNH LÊN THÀNH SAU
Authors: Văn Tân Nguyễn , Văn Vinh Châu , Thị Kim Phượng Lê , Văn Tuyến Đỗ , Long Bùi 
Published: July 2021

Mục tiêu: Khảo sát tỉ lệ và một số đặc điểm tổn thương động mạch vành ở bệnh nhân NMCT cấp ST chênh lên thành sau tại Bệnh viện Thống Nhất - TP. Hồ Chí Minh. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả và phân tích trên tất cả bệnh nhân NMCT cấp ST chênh lên thành saunhập viện điều trị tại bệnh viện Thống Nhất từ tháng 1/2017 đến 6/2020. Kết quả: Tuổi trung bình của nhóm bệnh nhân nghiên cứu là 61,0±12,7 (tuổi). Tỉ lệ NMCT cấp ST chênh lên thành saulà 20,5%. Choáng tim chiếm tỉ lệ 22,7%. ĐMV thủ phạm là nhánh LCx 59,1%, RCA 40,9%, nhánh RCA chiếm ưu thế hơn nhánh LCx (61,4% so với 38,6%, p=0,037). Nhánh LCx có vị trí tổn thương thường gặp là đoạn giữa 48%, tổn thương típ C 56%, dòng chảy TIMI 0 là 44%; trong khi đó vị trí tổn thương thường gặp trên nhánh RCA là đoạn gần 47,4%, típ C 63,2%, dòng chảy TIMI 0 là 36,8%. Kết luận: Nhồi máu cơ tim cấp ST chênh lên thành sau chiếm hơn 1/4 các trường hợp nhồi máu cơ tim ST chênh lên nhập viện. Tổn thương thủ phạm là động mạch vành mũ trong phần lớn các trường hợp, với vị trí tổn thương thường gặp là tại đoạn giữa.
SỰ BỘC LỘ THỤ THỂ ANDROGEN VÀ ESTROGEN TRONG UNG THƯ BIỂU MÔ TUYẾN VÚ XÂM NHẬP
Authors: Văn Chủ Nguyễn 
Published: July 2021

Thụ thể androgen (AR) liên quan tới một yếu tố phiên mã kiểm soát các gen đặc hiệu liên quan đến các quá trình tế bào khác nhau, đôi khi ngược lại: nó có thể kích thích hoặc ức chế cả tăng sinh tế bào và apoptosis, tùy thuộc vào các con đường tín hiệu đồng thời được hoạt hóa. Mục tiêu: Nhận xét một số mối liên quan giữa sự bộc lộ AR, ER với typ phân tử, NPI, nhóm nguy cơ và giai đoạn sau mổ của ung thư vú. Đối tượng và phương pháp nghiên cứu: Mẫu mô u của 94 bệnh nhân ung thư vú được nhuộm hóa mô miễn dịch với dấu ấn AR, ER để xác định kiểu hình miễn dịch và đánh giá mối liên quan với một số đặc điểm GPB. Kết quả nghiên cứu: Ở typ phân tử HER2, nhóm AR-ER- chiếm tỷ lệ cao nhất (55,9%) và ung thư vú dạng đáy, kiểu hình AR+ER- chiếm tỷ lệ phổ biến nhất là 52,9%. AR-ER- chiếm tỷ lệ cao nhất ở ung thư vú nguy cơ xấu (58,8%). Ung thư vú giai đoạn I nhóm AR-ER+ và AR+ER+ đều chiếm tỷ lệ cao hơn giai đoạn III (lần lượt là 40,0 vs 13,3% và 29,8 vs 21,5%). Kết luận: Kiểu hình miễn dịch AR-ER- thường kết hợp với các đặc trưng GPB xấu nhất.
ĐÁNH GIÁ TÌNH TRẠNG SẮT VÀ FERRITIN HUYẾT THANH Ở BỆNH NHÂN SUY THẬN MẠN CHƯA ĐIỀU TRỊ THAY THẾ TẠI BỆNH VIỆN TRUNG ƯƠNG THÁI NGUYÊN
Authors: Thị Hải Yến Nguyễn , Thị Ngọc Hà Nguyễn , Thị Thu Hương Lâm , Thu Hà Nguyễn 
Published: July 2021

Mục tiêu: Phân tích mối liên quan giữa sắt và ferritin huyết thanh với tình trạng thiếu máu trên bệnh nhân suy thận mãn chưa điều trị thay thế. Đối tượng và phương pháp nghiên cứu: Phương pháp nghiên cứu mô tả cắt ngang tiến hành trên 46 bệnh nhân được chẩn đoán suy thận mạn giai đoạn III, IV chưa điều trị thay thế (chưa lọc máu chu kỳ), điều trị nội trú tại khoa Thận – Tiết niệu – Bệnh viện Trung ương Thái Nguyên. Kết quả và kết luận: Nồng độ sắt trung bình là 12,41±12,04µmol/l. Tỷ lệ bệnh nhân có nồng độ sắt huyết thanh giảm là 32,6%. Không có sự khác biệt về nồng độ sắt huyết thanh giữa nam giới và nữ giới và giữa các độ tuổi. Nồng đồ ferritin trung bình là 461,43±343,75ng/ml. Có 26,1% bệnh nhân có dự trữ sắt thấp (nồng độ ferritin < 200 ng/ml), 32,6% bệnh nhân có dự trữ sắt trung bình (nồng độ ferritin từ 200-500 ng/ml) và 41,3% bệnh nhân có tăng dự trữ sắt (nồng độ ferritin≥ 500ng/ml). Nồng độ ferritin huyết thanh có sự khác biệt giữa nam giới và nữ giới (nam lớn hơn nữ). Không có mối tương quan giữa nồng độ sắt và ferritin huyết thanh p>0,05. Không thấy mối liên quan giữa nồng độ sắt và ferritin huyết thanh với các mức độ thiếu máu.
EFECTOS DEL MARCO REGULATORIO Y LAS DINÁMICAS COMPETITIVAS DE LAS EMPRESAS DE TELEFONÍA MÓVIL EN EL PERU (1993-2018)
Authors: PECEROS VALENCIA MARILIA SUSANA 
Published: July 2021

La evolución de la telefonía móvil en el Perú desde 1993 hasta nuestros días, a diferencia de otros países fue muy particular, pues su proceso de privatización atravesó un periodo de concurrencia, etapa en la que se restringía la competencia a nuevos operadores, situación que permitió a Telefónica del Perú S.A. obtener ventajas que fueron sostenidas en el tiempo; sin embargo superada la etapa de concurrencia y sus efectos, el ingreso de nuevas operadoras entre operadoras móviles virtuales y las que cuentan con espectro, así como el nuevo marco regulatorio han posibilitado un escenario de competencia que beneficia a los consumidores.
ABSTRACT
The evolution of mobile telephone services in Peru since 1993, unlike other countries, was unusual because its privatization process went through a period in which competition was restricted to new operators, a situation that allowed Telefonica del Peru SA to obtain advantages that were sustained over time; however, after the initial privatization, the entry of new operators, among them virtual mobile operators and those without spectrum, as well as the new Regulatory Law, had made a competitive scenario that benefits customers.
Seasonal distribution and drivers of surface fine particulate matter and organic aerosol over the Indo-Gangetic Plain
Authors: Mogno Caterina , Palmer Paul I. , Knote Christoph , Yao Fei , Wallington Timothy J. 
Published: July 2021

Abstract. The Indo-Gangetic Plain (IGP) is home to 9 % of the global population and is responsible for a
large fraction of agricultural crop production in Pakistan, India, and Bangladesh. Levels of fine particulate matter (mean diameter <2.5 µm, PM2.5)
across the IGP often exceed human health recommendations, making
cities across the IGP among the most polluted in the world. Seasonal
changes in the physical environment over the IGP are dominated by the
large-scale south Asian monsoon system that dictates the timing of
agricultural planting and harvesting. We use the WRF-Chem model to study the seasonal anthropogenic,
pyrogenic, and biogenic influences on fine particulate matter and its
constituent organic aerosol (OA) over the IGP
that straddles Pakistan, India, and Bangladesh during 2017–2018. We find that surface air quality
during pre-monsoon (March–May) and monsoon (June–September) seasons is
better than during post-monsoon (October–December) and winter
(January–February) seasons, but all seasonal mean values of PM2.5
still exceed the recommended levels, so that air pollution is a year-round problem. Anthropogenic
emissions influence the magnitude and distribution of PM2.5 and
OA throughout the year, especially over urban sites, while pyrogenic
emissions result in localised contributions over the central and upper
parts of IGP in all non-monsoonal seasons, with the highest impact during
post-monsoon seasons that correspond to the post-harvest season in the
agricultural calendar. Biogenic emissions play an important role in
the magnitude and distribution of PM2.5 and OA during the monsoon
season, and they show a substantial contribution to secondary OA (SOA),
particularly over the lower IGP. We find that the OA contribution to
PM2.5 is significant in all four seasons (17 %–30 %), with primary
OA generally representing the larger fractional contribution. We find
that the volatility distribution of SOA is driven mainly by the mean
total OA loading and the washout of aerosols and gas-phase aerosol
precursors that result in SOA being less volatile during the
pre-monsoon and monsoon season than during the post-monsoon and winter
seasons.
The CO2 integral emission by the megacity of St Petersburg as quantified from ground-based FTIR measurements combined with dispersion modelling
Authors: Ionov Dmitry V. , Makarova Maria V. , Hase Frank , Foka Stefani C. , Kostsov Vladimir S. , Alberti Carlos , Blumenstock Thomas , Warneke Thorsten , Virolainen Yana A. 
Published: July 2021

Abstract. The anthropogenic impact is a major factor of climate
change, which is highest in industrial regions and modern megacities.
Megacities are a significant source of emissions of various substances into
the atmosphere, including CO2 which is the most important anthropogenic
greenhouse gas. In 2019 and 2020, the mobile experiment EMME (Emission
Monitoring Mobile Experiment) was carried out on the territory of St
Petersburg which is the second-largest industrial city in Russia with a
population of more than 5 million people. In 2020, several measurement data
sets were obtained during the lockdown period caused by the COVID-19
(COronaVIrus Disease of 2019) pandemic. One of the goals of EMME was to
evaluate the CO2 emission from the St Petersburg agglomeration.
Previously, the CO2 area flux has been obtained from the data of the
EMME-2019 experiment using the mass balance approach. The value of the
CO2 area flux for St Petersburg has been estimated as being 89±28 kt km−2 yr−1, which is 3 times higher than the
corresponding value reported in the official municipal inventory. The
present study is focused on the derivation of the integral CO2 emission from St Petersburg by coupling the results of the EMME observational campaigns of 2019 and 2020 and the HYSPLIT (HYbrid Single-Particle Lagrangian Integrated Trajectories) model. The ODIAC (Open-Data Inventory for Anthropogenic CO2) database is used as the source of the a priori information on the CO2 emissions for the territory of St Petersburg. The most important finding of the present study, based on the analysis of two observational campaigns, is a significantly higher CO2
emission from the megacity of St Petersburg compared to the data of
municipal inventory, i.e. ∼75800±5400 kt yr−1 for
2019 and ∼68400±7100 kt yr−1 for 2020 versus
∼30 000 kt yr−1 reported by official inventory. The
comparison of the CO2 emissions obtained during the COVID-19
lockdown period in 2020 to the results obtained during the same period of
2019 demonstrated the decrease in emissions of 10 % or
7400 kt yr−1.
Influence of different types of ionospheric disturbances on GPS signals at polar latitudes
Authors: Belakhovsky Vladimir B. , Jin Yaqi , Miloch Wojciech J. 
Published: July 2021

Abstract. The comparative research of the influence of different types of auroral particle precipitation and polar cap patches (PCPs) on the global positioning system (GPS) signals disturbances in the polar ionosphere was done. For this purpose, we use the GPS scintillation receivers at Ny-Ålesund and Skibotn, operated by the University of Oslo. The presence of the auroral particle precipitation and polar cap patches was determined by using data from the EISCAT 42m radar on Svalbard. The optical aurora observations in 557.7 and 630.0 nm spectrum lines on Svalbard were used as well for the detection of
ionospheric disturbances. The cusp identification was done with using SuperDARN (Hankasalmi) data. We consider events when the simultaneous EISCAT 42m and GPS data were available for the years 2010–2017, and in this paper we present, in detail, typical examples describing the overall picture, and we present the statistics for 120 events. We considered the dayside/cusp precipitation, substorm precipitation, daytime and nighttime PCPs, and precipitation associated with the interplanetary shock wave arrival. We demonstrate that substorm-associated precipitation (even without PCPs) can lead to a strong GPS phase (σϕ) scintillations up to ∼ 1.5–3 radians, which is much stronger than those usually produced by other types of considered ionosphere disturbances. The value of the substorm-phase scintillations in general correlate with the value of the geomagnetic field disturbance. But sometimes even a small geomagnetic substorm, when combined with the PCPs, produces quite strong phase scintillations. Cusp phase scintillations are lower than dayside PCPs scintillations. PCPs can lead to stronger ROT (rate of total electron content) variations than other types of ionosphere disturbances. So our observations suggest that the substorms and PCPs, being different types of the high-latitude disturbances, lead to the development of different types and scales of ionospheric irregularities.
Updating search strategies for literature reviews with OUR2D2: an open-source computer application
Authors: Lohr Abby M , Van Gorden Noah , McClelland D Jean , Dubinsky Ellen , Gerald Lynn B , Wilkinson-Lee Ada , Carvajal Scott C 
Published: July 2021

Background: While writing a scoping review, we needed to update our search strategy. We wanted to capture articles generated by our additional search terms and articles published since our original search. Simultaneously, we strove to optimize project resources by not rescreening articles that had been captured in our original results.Case presentation: In response, we created Open Update Re-run Deduplicate (OUR2D2), a computer application that allows the user to compare search results from a variety of library databases. OUR2D2 supports extensible markup language (XML) files from EndNote and comma-separated values (CSV) files using article titles for comparisons. We conducted unit tests to ensure appropriate functionality as well as accurate data extraction and analysis. We tested OUR2D2 by comparing original and updated search results from PubMed, Embase, Clarivate Web of Science, CINAHL, Scopus, ProQuest Dissertation and Theses, and Lens and estimate that this application saved twenty-one hours of work during the screening process.Conclusions: OUR2D2 could be useful for individuals seeking to update literature review strategies across fields without rescreening articles from previous searches. Because the OUR2D2 source code is freely available with a permissive license, we recommend this application for researchers conducting literature reviews who need to update their search results over time, want a powerful and flexible analysis framework, and may not have access to paid subscription tools.
А rare tumor in the practice of oncoophthalmologist — is an oncocytoma of the lacrimal gland
Authors: Shimotkina Е. V. , Semenova L. Е. , Vlasova О. S. , Kuchenkova I. А. 
Published: July 2021

Introduction. Oncocytoma is an epithelial tumor, characterized by a benign course and has a favorable prognosis. The description of this clinical case is due to the rare occurrence of lacrimal gland oncocytoma in clinical practice and a small number of publications in the literature.Methods. A case study of the lacrimal gland oncocytoma is presented in a young patient, followed up for a long time.Results. The presented clinical case demonstrates the need for morphological diagnosis of lacrimal gland formations, despite the benign nature of the tumor and the favorable course of the disease. Discussion. Analysis of a clinical example and a review of the literature clearly demonstrates the need for differential diagnosis of tumors of the lacrimal gland.Conclusion. It is necessary to include the described pathology in the differential diagnostics of any neoplasms of the lacrimal gland and orbit in order to prevent an unwarranted expansion of surgical intervention, with subsequent dynamic monitoring of patients with this pathology.
Own experience of mri T2 and ct perfusion of the brain, how to avoid «failures»
Authors: Sukhanov V. A. , Chernova О. N. , Shubny М. О. , Shtentsel R. Е. 
Published: July 2021

Introduction.To reduce the number of cerebral perfusion studies, the interpretation of which is not possible or can be performed with errors, we retrospectively analyzed cerebral perfusion studies for three years, analyzed the identified errors at the stage of data collection and the stage of study interpretation.Aims and objectives:to analyze and divide into groups the reasons that led to limitations or impossibility to assess perfusion during interpretation of the obtained data, to develop an algorithm of actions to reduce the number of uninterpreted studies.Materials and Methods.The study retrospectively evaluated 275 CT and MRI brain perfusion studies performed between 2017 and 2019 on 1.5 T MR and 32-slice CT scans.Results.The result of this study was a better understanding of the causes of the most common errors in perfusion studies. Analysis of the causes allowed us to identify factors that affect the performance of the study and the interpretation of the data obtained. Discussion.In order to perform a quality perfusion study, given the many factors affecting the interpretation of the data obtained, a number of conditions on the planning and execution of the study, as well as on the evaluation of the data obtained, must be followed.Conclusions.Understanding the reasons that lead to limitations or inability to evaluate MRI and CT perfusion studies, adhering to guidelines for planning and evaluating studies allows for correct data and avoids obtaining uninformative studies or studies whose interpretation is limited.
Intrapleural port systems as a technology for the control of recurrent metastatic exudative pleurisy. first experience
Authors: Pecheritsa Е. D. , Lukin А. А. , Gnatyuk Y. А. , Galkin А. О. 
Published: July 2021

Introduction.To evaluate the immediate results of the first experience of implantation of an interpleural port system in comparison with traditional methods of pleural fluid evacuation and improve the quality of life of patients with recurrent metastatic pleurisy.Materials and methods.A prospective study of 14 cases with recurrence of metastatic pleurisy in 6 months was carried out. 2020 year. The patients were divided into group A (traditional methods of pleurisy evacuation) and group B (implantation of an interpleural port system). The manipulations were performed under local anesthesia.Results. Pneumothorax was diagnosed in 6 patients (43%) after thoracocentesis and implantation of the port system. In group B, 3 people (21%) had a small pneumothorax, the air was evacuated with a Huber needle. In group A, 3 people (21%) required drainage of the pleural cavity, which delayed hospitalization. In 11 people (78%), of which 7 people (50%) from group B, a clinical decrease in respiratory failure up to stage II. 7 patients (50%) from group B noted the absence of pain and discomfort after surgery. 14 (100%) patients were diagnosed with a recurrence of metastatic pleurisy on day 21, which required hospitalization of patients from group A to a hospital for drainage of the pleural cavity. In group B patients, fluid evacuation was performed on an outpatient basis, thereby not lengthening the period of systemic anticancer therapy. 4 patients (28%) managed to continue antitumor therapy on time. Infectious complications in 3 patients (21%) from group A, where air leakage persisted against the background of tumor disintegration.Conclusion.The intrapleural port system improves the quality of life, eliminating complications from repeated punctures of the pleural cavity. Simple installation under local anesthesia with the possibility of discharge from the hospital on the 2nd day. Evacuation of pleurisy through the port system by nurses on an outpatient basis. Possibility of intrapleural antitumor therapy and pleural obliteration through the port system.
Analysis of economic efficiency of iron deficiency anemia therapy in patients with malignant tumors
Authors: Saevets V. V. , Alekseeva А. Р. , Taratonov А. V. , Muhin А. А. , Chizhovskaja А. V. 
Published: July 2021

Introduction. Correction of iron deficiency anemia in patients with malignant neoplasms is an important aspect affecting the quality of life and the effectiveness of special treatments. At the same time, the therapy of comorbid conditions significantly increases the cost of treating cancer patients.The aim of the study was to conduct a comparative pharmacoeconomic analysis of the two most common methods for correcting iron deficiency anemia in cancer patients: transfusion of erythrocyte suspension and intravenous iron preparations using iron carboxymaltose as an example.Materials and methods. An observational, analytical, cohort study was carried out, which included 120 cancer patients. The patients underwent laboratory examination. The tests were assessed: a general blood test with an assessment of the morphological characteristics of erythrocytes, serum iron, ferritin, CRP, total protein. An analysis of the costs of iron deficiency anemia therapy was carried out, taking into account the procurement cost of drugs.Results. It is economically more profitable to use intravenous iron preparations in comparison with transfusion of erythrocyte suspension for the treatment of iron deficiency anemia in patients with malignant neoplasms. The cost of correcting iron deficiency anemia per patient was: when treated with carboxymaltosate iron (Ferinject): 7943.96 rubles, with transfusion of erythrocyte suspension: 16856.40 rubles.Conclusion. In the treatment of anemia in patients with malignant neoplasms with blood preparations (erythrocyte suspension), an improvement in hematological parameters is noted earlier and to a greater extent than with the use of iron preparation carboxymaltozate («Ferinject»). Nevertheless, the duration of the clinical effect when using erythrocyte suspension is lower than that of a parenteral iron preparation.