bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular features evaluation of metastatic foci as the basis for metastatic breast cancer treatment personalization. Is there a place of CDK4/6-inhibitors in late-line therapy after chemotherapeutic regimens?
Authors: Stukan A. I. , Goryainova A. Y. , Lymar E. V. , Sharov S. V. , Antipova V. V. 
Published: December 2021

The problem of metastatic breast cancer treatment is linked with clonal selection both in the process of tumor evolution and under the influence of previous treatment. The analysis of metastatic niche microenvironment and the molecular genetic features become essential for treatment individualization. Studies demonstrate hormonal expression and epidermal growth factor receptor (HER2neu) discordance between the primary tumor and the metastatic focus. The advantages of combined hormone therapy (CНT) with CDK4/6 inhibitors were revealed in comparison with hormone therapy (НT) with survival rates benefits in the 1st and 2nd lines of НT, as well as after the 1st line of chemotherapy in clinical trials. However, there are lack of data on patients with multiple lines of chemotherapy. In the present retrospective study, more than half of the patients were treated palliative chemotherapy before administration of CDK4/6 inhibitors. Main metastatic foci represented luminal types after biopsy, however, loss of progesterone receptor expression was noted with the initial luminal A-subtype. At the time of the data cut-off, most patients have a longterm clinical effect, improvement conditions and reduction of pain, including the cases of late line CHT setting after chemotherapeutic regimens. Taking into account the heterogeneity of metastatic breast cancer, clonal selection and phenotype discordance there is the crucial need for molecular and genetic characteristics of the metastatic process. At the same time it is possible to consider the appointment of combined hormone therapy with CDK4/6 inhibitors as additional option for late-line treatment of the disseminated process. Prospective studies on combined hormonal therapy with CDK4/6 inhibitors in metastatic breast cancer in late lines of therapy with proven HR+HER2neu-negative receptor status of the metastatic focus are strongly recommended.
Efficacy of lorlatinib in the treatment of ALK-positive non-small cell lung cancer patients with progression on crizotinib: personal experience
Authors: Laktionov K. K. , Reutova E. V. , Kruteleva S. Yu. , Antonova E. Yu. 
Published: December 2021

Introduction. Lorlatinib is a third generation ALK tyrosine kinase inhibitor. Back in 2018, the drug underwent accelerated FDA approval and was recommended for the treatment of patients with ALK-positive non-small cell lung cancer after progression on crizotinib and another ALK inhibitor. For a long time, the use of the drug in Russia was possible only in clinical trials or expanded access program. However, now this drug is becoming available in our country.Purpose. To analyze the overall and intracranial response during lorlatinib therapy, as well as the tolerability of lorlatinib therapy in patients with ALK-positive non-small cell lung cancer who previously received crizotinib and one or more lines of cytostatic therapy.Materials and methods. The study included 39 patients aged 28 to 76 years, diagnosed with non-small cell lung cancer. In 36 cases, a translocation in the ALK gene was detected, in three, a ROS1 translocation. All patients received targeted therapy with crizotinib and one or more lines of chemotherapy before starting lorlatinib therapy. All patients received 100 mg lorlatinib therapy until disease progression or intolerable toxicity.Results. During the observation period for the moment of September 2021, an objective response was achieved in 28 patients (71.7%), in 10 patients (25.6%) – stabilization of the disease, in one patient (2.6%) – progression. The median duration of the drug was just over 40 months. The drug intake was characterized by a predictable and manageable toxicity profile.Conclusions. These data indicate a high direct efficacy of lorlatinib in patients with ALK/ROS1 translocations. The data obtained do not contradict the results obtained in the course of clinical trials. The drug lorlatinib has currently received registration in Russia for the treatment of non-small cell lung cancer in cases of the development of progression while taking secondgeneration ALK inhibitors or several lines of therapy with ALK inhibitors.
Role of Post-Neoadjuvant therapy with trastuzumab emtansine in HER2-positive breast cancer
Authors: Lubennikova E. V. , Vishnevskaya Ya. V. 
Published: December 2021

The widespread introduction of anti-HER2 agents has changed the natural course of Her2-positive breast cancer. The use of trastuzumab, and later dual anti-HER2 blockade with pertuzumab, in neoadjuvant regimens significantly increased the chances of complete cure. However, among patients with early and locally advanced forms of Her2-positive cancer, there is a cohort with an extremely unfavorable prognosis – tumors that have not achieved complete pathomorphological regression after neoadjuvant chemotherapy.The presence of a residual tumor in Her2-positive breast cancer has long been only a prognostically unfavorable factor without the potential to influence disease outcome. The results of the international phase III study KATHERINE, which demonstrated the high efficacy of post-adjuvant therapy with trastuzumab emtansine (T-DM1) in this patient cohort, have established a new standard of care. Due to T-DM1 adjuvant therapy, the possibility to significantly improve long-term results determined the predictive characteristics of the morphological response to the choice of treatment tactics, which became an important argument in favor of neoadjuvant therapy in patients with not only locally advanced but also primarily resectable Her2-positive breast cancer, followed by personalization of therapy.This article presents our own experience with post-neoadjuvant therapy with trastuzumab emtansine in a young patient with a residual tumor. The data of the main studies in early Her2-positive breast cancer are summarized.
Target therapy of luminal HER2-negative advanced breast cancer with PIK3CA mutation: combination of alpelisib plus fulvestrant in real clinical practice
Authors: Filonenko D. A. , Ibragimova T. M. , Polshina N. I. , Belogurova A. V. , Khatkova E. I. , Arutiunian E. A. , Volkova E. I. , Zhukova L. G. 
Published: December 2021

Introduction. Сombination of alpelisib plus fulvestrant is approved in patients with hormone receptor positive, HER2-negative, PIK3CA-mutated advanced breast cancer (ABC) after progression on hormonotherapy. Efficacy data of alpelisib in heavily pretreated patients with HR+/HER-2-, PIK3CA-mutated advanced breast cancer are limited, only results from phase I trial are available. Here we report our results of alpelisib efficacy in 19 heavily pretreated patients.Object: to evaluate efficacy and safety of combination alpelisib plus fulvestrant in patients with HR+/HER2-, PIK3CA-mutated advanced breast cancer in initial and later lines of therapy in real clinical practice.Materials and methods. Combination of alpelisib plus fulvestrant was investigated in 19 patients with HR+/HER2-, PIK3CAmutated ABC, alpelisib at a dose of 300 mg per day plus fulvestrant at a dose of 500 mg i.m. every 28 days and once on day 15. Treatment continued until disease progression or unacceptable toxicity.Results. From February 2021 19 patients with HR+/HER2-, PIK3CA-mutated advanced breast cancer were treated with alpelisib plus fulvestrant. The data cut off is October 2021. Median lines of treatment in advanced disease was five, including 19 (100%) patients received CDK4/6, 14 (74%) – fulvestrant and/or everolimus and 15 (79%) – chemotherapy. 4 (21%) received alpelisib in a second line, 15 (79%) – in subsequent lines. Median progression-free survival was 7 months. The response was evaluated in 18 patients: partial response was achieved in 5 (28%) patients, stable disease – in 9 (50%), disease progression – 4 (22%). The most frequent adverse events were hyperglycemia – 74% (grade 3 – 22%), creatinine increased – 42% and rash – 37% (grade 3 – 22%). Only one patient has discontinued the treatment due to Quincke`s edema.Conclusions. Combination of alpelisib with fulvestrant is an effective option both in initial and later lines of therapy in patients with HR+/HER2-, PIK3CA-mutated advanced breast cancer including fulvestrant, CDK4/6 inhibitors and/or everolimus – pretreated patients.
Prognostic value of the proportion of the sclerosing component in fibrolamellar liver carcinoma
Authors: Antonova E. Yu. , Moroz E. A. , Podluzhny D. V. , Kudashkin N. E. , Dzhanyan I. A. , Volkov A. Yu. , Laktionov K. K. , Breder V. V. 
Published: December 2021

Introduction. Fibrolamellar hepatocellular carcinoma (FLC), which develops most often in the younger population. In FLC, variable histoarchitectonics are noted, possibly the presence of a sclerosing component, foci of necrosis and dystrophy of tumor cells.Objective. Assessment of the influence of the proportion of the sclerosing component in fibrolamellar carcinoma (FLC) of the liver on the course and prognosis of the disease. Determination of the relationship between the proportion of the sclerosing component in the tumor and the frequency of microvascular invasion.Materials and methods. A retrospective study included 34 patients with a diagnosis of FLC, who underwent radical surgical treatment at the first stage. A histological assessment of the proportion (%) of the sclerosing component in FLC was made. The effect of the proportion of the sclerosing component on overall (OS) and relapse-free (DFS) survival was assessed. The analysis of the relationship between the proportion of the sclerosing component in the tumor and the frequency of microvascular invasion was carried out.Results. Significantly worse RFS was achieved in the groups of patients with a sclerosing component in FLC > 5% than in the group of patients with a sclerosing component in FLC ≤ 5% (p = 0.0010; p = 0.024; log – rank test). Median DDS in group 1 is 107 (95% CI, 22–192) months; at 2 – 11 (95% CI, 8–14) months; in 3 – 21 (95% CI, 8–33). The frequency of histologically confirmed microvascular invasion in the compared groups was 29, 74, 87.5%, respectively. OS was significantly worse in 2 groups (27 patients in total) with a sclerosing component in FLC > 5% than in the group of patients with a sclerosing component in FLC ≤ 5%. Median OS in group 1 120 (95% CI, 60–180) months; at 2 – 41 (95% CI, 15–92) months; in 3 – 69 (95% CI, 35–103). A direct relationship was found between an increase in the proportion of the sclerosing component in a tumor and an increase in the frequency of microvascular invasion.Conclusions. We can assume that the severity of the sclerosing component in the FLK tumor can serve as an effective morphological marker of a less favorable prognosis for this HCC subtype and correlate with the frequency of microvascular invasion.
School strategy in developing religious character education of students at MTs Tangerang
Authors: Sutarman Sutarman 
Published: December 2021

The purpose of this research is to find out the extent of the school's strategy to develop character education that is applied to students about religion and its habits. Research method with a qualitative approach that describes in detail and depth. Data collection techniques through (1) Interviews with key volunteers who know the focus of problems in the school (2). Survey of school locations as research sites, to find phenomena that occur as data to be used in research (3). Documentation studies in the form of photographs, data, archives, of the school so that it can be understood by related components such as principals, teachers, students, education staff, parents, and school committees (2). Implementation of running every program that has been designed properly and correctly, in accordance with the schedule and guidelines (3). An evaluation that oversees the implementation of the activities carried out so that it continues to be structured with the policies that have been planned so that the implementation is directed, as well as any programs that are running or those that have not been controlled and always provide direction.
Visualization Process of Temporary Converted Facilities to Accommodate Quarantine and Treatment Centre (PKRC) Layouts in Malaysia Agriculture Expo Park Serdang (MAEPS)
Authors: Muhammad Siti Aisyah , Hanafi Nik Nurul Hana , Tengku Anuar Tengku Fauzan , Hequan Zhang 
Published: December 2021

This study aims to develop a reference platform for converting Malaysia Agriculture Expo Park Serdang (MAEPS) to the Low-Risk COVID-19 Quarantine and Treatment Centre (PKRC) to face the increased numbers Covid-19. This study employed qualitative methodologies and further developed 3D modeling involving AutoCAD, SketchUp, and V-Ray software. The limitation is developing a 3D model visualization of MAEPS on Phase 1 and Phase 2 at Hall A only. The findings display the application of 3D visualization potentially becomes a reference to creating the quarantine centre in the future.

Keywords: Covid-19; pandemic; quarantine centre; 3D visualization

eISSN: 2398-4287© 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v6i18.3055
Perception of Soft Contact Lens Usage among Health Sciences and Business Management Students
Authors: Ahmad Najmee Nur Aresya , Abu Hassan Nur Fazliana , Muhamad Nurulain , Saliman Noor Haziq 
Published: December 2021

The knowledge and awareness on contact lens care can enhance the positive attitude of the wearers and reduce related complications. This study aimed to investigate the perceptions of contact lens use and care of university students with different backgrounds. A questionnaire regarding the perception and practice of contact lens use was online distributed. The perception of contact lens use as an optical device between spectacle and contact lens was statistically significant (p<0.05). However, there was no significant difference between the perception and awareness of two groups (p>0.05). Regardless of educational field background, all contact lens wearers have the same behavioural assessment of contact lens awareness.
Keywords: behaviour, contact lens usage, knowledge, awareness.
eISSN: 2398-4287© 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v6i18.3058
The Malay Socio-Cultural Elements in Selected Malaysian Paintings of the Hashim Hassan
Authors: Abdullah Ahmad Hakim , Abdillah Nasirin 
Published: December 2021

This study focuses on the works of Hashim Hassan paintings. The artist is known for showcasing the essence of the Malay socio-cultural and philosophy that is in-depth within the community. This research method emphasises qualitative methods such as in-depth interviews, observations, voice recordings and data transcripts. The findings depict the philosophical and Malay socio-cultural meaning of Wau Bulan Terbang Malam (2007); the painting resonates with the classic Malay song by Tan Sri. P. Ramlee. The painting is also an inspiration for the Malay banknotes and coins, the graphic design logo of Malaysia Airlines Berhad and Wau Bulan Monuments.
Keywords: Hashim Hassan; Malaysian; Malay Socio-Cultural Elements; Paintings
eISSN 2398-4287 © 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., U.K. This is an open-access publication under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer-review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
Doi: https://doi.org/10.21834/ebpj.v6i18.3061
Socio-demographic Factors and Eating Behaviours among Nurses in a Teaching Hospital
Authors: Mohamad Norfidah , Abdul Mulud Zamzaliza , Ruzli Ira Nadhira , Mohd Zainun Zaman Nur Ain Farhah 
Published: December 2021

Nurses are known as shift workers. Shift work can disrupt regular meal habits resulting in abnormal eating behaviour. Hence, this study aims to determine the relationship between socio-demographic factors and eating behaviour. A cross-sectional study was conducted among 135 nurses using a self-administered questionnaire. This study found that the shift duties factor was significantly associated with emotional and external eating behaviour. This might be caused by how nurses cope with the burden of shift works. Health promotion strategies from both individuals and organisations should be intensified for these nurses to enhance healthy eating habits and promote healthy lifestyles.
Keywords: eating behaviour; shift duty; nurses
eISSN: 2398-4287© 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v6i18.3071
Effects of Mindfulness-Based Stress Reduction (MBSR) Program on Anxiety and Depression and HRQoL among Cancer Patients in Malaysia.
Authors: Othman Che Noriah Binti , Syed Sulaiman Syed Azhar , Farooqui Maryam , Ismail Wan Ismahaniza 
Published: December 2021

Anxiety and depression are common among cancer patients and impact health-related quality of life. MBSR has long been used to treat psychological illnesses in various therapeutic settings worldwide. However, there is no solid evidence of MBSR effects among cancer patients in Malaysia. This cross-sectional study intervened in the five weeks of MBSR on cancer patients in Penang. Results found that the MBSR Intervention group had lower anxiety and depression compared to the waitlist. However, the HRQOL result was inconclusive. These findings support the use of the MBSR program for Anxiety and Depression among cancer patients. However, HRQOL needs further investigation.
Keywords: MBSR, HRQOL, Cancer Patients, Cognitive and Affective Mindfulness
eISSN: 2398-4287© 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v6i18.3072
A Qualitative Study of Psychological Challenges towards Movement Control Order among Stranded University Students
Authors: Yusof Suzana , Mohd Bakr Nurul Amirah , Che Wahab Umi Syafiqah , Wilandika Angga 
Published: December 2021

The stranded students were vulnerable to developing psychological problems as they were separated from their families and lived alone. This research aimed to explore the psychological challenges experienced by stranded university students and support that assists those dealing with the challenges during MCO. This qualitative phenomenology study was conducted using in-depth and focus group interviews via online meetings. A total of 12 stranded university students were selected. Three themes emerged from the analyses: psychological challenges, hoping for better management in disaster conditions, and financial and emotional supports are survival during stranded in MCO situations.
Keywords: Movement Control Order (MCO); psychological challenges; stranded; university students

eISSN: 2398-4287© 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v6i18.3078
Motivation and Hygiene Factors of Work Satisfaction among Intensive Care Nurses in Selangor
Authors: Wan Ismail Wan Marina , Majid Norhaini , Suryanto Suryanto 
Published: December 2021

The work satisfaction among nurses is essential in a healthcare system. Nurse satisfaction may refer to the motivation to stay in the nursing profession and the organization in which they are satisfied with. The study aims to determine the level of work satisfaction among Intensive Care nurses and examined the relationship between Herzberg’s motivation and hygiene factors. The study used a quantitative design with a theoretical framework based on Herzberg’s theory. A total of 218 nurses from the Intensive Care Unit were selected. The results showed that overall, of the nurses had a moderate level of work satisfaction.
Keywords: Work satisfaction, motivation, hygiene, nurses
eISSN: 2398-4287© 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v6i18.3090