bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing an Educational Website for Women With Endometriosis-Associated Dyspareunia: Usability and Stigma Analysis
Authors: Abdulai Abdul-Fatawu , Howard A Fuchsia , Yong Paul J , Noga Heather , Parmar Gurkiran , Currie Leanne M 
Published: November 2021

Background
Endometriosis is a chronic condition that affects approximately 10% of women worldwide. Despite its wide prevalence, knowledge of endometriosis symptoms, such as pelvic pain, and treatments remains relatively low. This not only leads to a trivialization of symptoms and delayed diagnosis but also fuels myths and misconceptions about pain symptoms. At the same time, the use of web-based platforms for information seeking is particularly common among people with conditions that are perceived as stigmatizing and difficult to discuss. The Sex, Pain, and Endometriosis website is an educational resource designed to provide evidence-based information on endometriosis and sexual pain to help people understand the condition, feel empowered, dispel myths, and destigmatize endometriosis-associated sexual pain.

Objective
The study objective is to evaluate the usability of the website and assess for destigmatizing properties of sexual health–related web-based resources.

Methods
We conducted a usability analysis by using a think-aloud observation, a postsystem usability questionnaire, and follow-up interviews with 12 women with endometriosis. The think-aloud data were analyzed using the framework by Kushniruk and Patel for analyzing usability video data, the questionnaire data were analyzed using descriptive statistics, and the follow-up interviews were analyzed using simple content analysis. We conducted a usability assessment by deductively analyzing the interview data via a trauma-informed care framework and a content analysis approach.

Results
Through usability analysis, we found the website to be simple, uncluttered, satisfying, and easy to use. However, 30 minor usability problems related to navigation; website response; the comprehension of graphics, icons, and tabs; the understanding of content; and mismatch between the website and users’ expectations were reported. In our stigma analysis, we found the web content to be nonstigmatizing. The participants suggested ways in which websites could be designed to address stigma, including ensuring privacy, anonymity, inclusiveness, and factual and nonjudgmental content, as well as providing opportunities for web-based engagement.

Conclusions
Overall, the participants found the website to be useful, easy to use, and satisfying. The usability problems identified were largely minor and informed the website redesign process. In the context of the limited literature on stigma and website design, this paper offers useful strategies on how sexual health–related websites can be designed to be acceptable and less stigmatizing to individuals with sensitive health issues.
Análisis de las trampas del desarrollo de Collier y del Designing Process de Barzelay en los programas de desarrollo con enfoque territorial en Antioquia
Authors: Urrego Estrada Gleidy Alexandra , Gutiérrez-Ossa Jahir A. 
Published: November 2021

El artículo plantea la reflexión acerca de las trampas del desarrollo sobre la perspectiva del conflicto, la política, los recursos y la vecindad y el designing process para el departamento de Antioquia. El abordaje metodológico es cualitativo con enfoque exploratorio de los planteamientos teóricos de Paul Collier y Michael Barzelay sobre las trampas del desarrollo y el designing process, respectivamente. De esta manera, el análisis planteado por Collier y Barzelay, de manera respectiva, evalúa la capacidad que tienen los territorios en principio a escala nacional para contribuir a resolver las diferencias en materia de conflicto, la política, los recursos naturales y la vecindad, prueba para ello, que la manera en que estos elementos son contemplados redunda en el mejoramiento de las condiciones de desarrollo entre los países o los conduce a unas trampas del desarrollo, consideradas en dichas materias. Seguido de ello, Barzelay plantea la necesidad de analizar los problemas desde una óptica holística, desde la que las dificultades surten la solución.
Islet Autoantibody Type-Specific Titer Thresholds Improve Stratification of Risk of Progression to Type 1 Diabetes in Children
Authors: Ng Kenney , Stavropoulos Harry , Anand Vibha , Veijola Riitta , Toppari Jorma , Maziarz Marlena , Lundgren Markus , Waugh Kathy , Frohnert Brigitte I. , Martin Frank , Hagopian William , Achenbach Peter 
Published: November 2021

OBJECTIVETo use islet autoantibody titers to improve the estimation of future type 1 diabetes risk in children.RESEARCH DESIGN AND METHODSProspective cohort studies in Finland, Germany, Sweden, and the U.S. followed 24,662 children at increased genetic or familial risk to develop islet autoimmunity and diabetes. For 1,604 children with confirmed positivity, titers of autoantibodies against insulin (IAA), GAD antibodies (GADA), and insulinoma-associated antigen 2 (IA-2A) were harmonized for diabetes risk analyses.RESULTSSurvival analysis from time of confirmed positivity revealed markedly different 5-year diabetes risks associated with IAA (n = 909), GADA (n = 1,076), and IA-2A (n = 714), when stratified by quartiles of titer, ranging from 19% (GADA 1st quartile) to 60% (IA-2A 4th quartile). The minimum titer associated with a maximum difference in 5-year risk differed for each autoantibody, corresponding to the 58.6th, 52.4th, and 10.2nd percentile of children specifically positive for each of IAA, GADA, and IA-2A, respectively. Using these autoantibody type-specific titer thresholds in the 1,481 children with all autoantibodies tested, the 5-year risk conferred by single (n = 954) and multiple (n = 527) autoantibodies could be stratified from 6 to 75% (P &lt; 0.0001). The thresholds effectively identified children with a ≥50% 5-year risk when considering age-specific autoantibody screening (57–65% positive predictive value and 56–74% sensitivity for ages 1–5 years). Multivariable analysis confirmed the significance of associations between the three autoantibody titers and diabetes risk, informing a childhood risk surveillance strategy.CONCLUSIONSThis study defined islet autoantibody type-specific titer thresholds that significantly improved type 1 diabetes risk stratification in children.
Clinically Relevant Circulating Protein Biomarkers for Type 1 Diabetes: Evidence From a Two-Sample Mendelian Randomization Study
Authors: Yazdanpanah Nahid , Yazdanpanah Mojgan , Wang Ye , Forgetta Vincenzo , Pollak Michael , Polychronakos Constantin , Richards J. Brent , Manousaki Despoina 
Published: November 2021

OBJECTIVE
To identify circulating proteins influencing type 1 diabetes susceptibility using Mendelian randomization (MR).

RESEARCH DESIGN AND METHODS
We used a large-scale two-sample MR study, using cis genetic determinants (protein quantitative trait loci [pQTL]) of up to 1,611 circulating proteins from five large genome-wide association studies, to screen for causal associations of these proteins with type 1 diabetes risk in 9,684 case subjects with type 1 diabetes and 15,743 control subjects. Further, pleiotropy-robust MR methods were used in sensitivity analyses using both cis and trans-pQTL.

RESULTS
We found that a genetically predicted SD increase in signal regulatory protein gamma (SIRPG) level was associated with increased risk of type 1 diabetes risk (MR odds ratio [OR] 1.66 [95% 1.36–2.03]; P = 7.1 × 10−7). The risk of type 1 diabetes increased almost twofold per genetically predicted standard deviation (SD) increase in interleukin-27 Epstein-Barr virus–induced 3 (IL27-EBI3) protein levels (MR OR 1.97 [95% CI 1.48–2.62]; P = 3.7 × 10−6). However, an SD increase in chymotrypsinogen B1 (CTRB1) was associated with decreased risk of type 1 diabetes (MR OR 0.84 [95% CI 0.77–0.90]; P = 6.1 × 10−6). Sensitivity analyses using MR methods testing for pleiotropy while including trans-pQTL showed similar results. While the MR-Egger suggested no pleotropic effect (P value MR-Egger intercept = 0.31), there was evidence of pleiotropy in MR-PRESSO (P value global test = 0.006).

CONCLUSIONS
We identified three novel circulating protein biomarkers associated with type 1 diabetes risk using an MR approach. These biomarkers are promising targets for development of drugs and/or of screening tools for early prediction of type 1 diabetes.
Effect of Deep Margin Elevation on Interfacial Gap Development of CAD/CAM Inlays after Thermomechanical Cycling
Authors: Moon W , Chung SH , Chang J 
Published: November 2021

SUMMARY
The aim of this study was to evaluate interfacial gap formation of CAD/CAM lithium disilicate inlay margins before and after thermomechanical loading.

Methods and Materials
Mesio-occlusal-distal cavities were prepared on 12 extracted mandibular molars. The gingival margin of one proximal box was elevated with resin modified glass ionomer (RMGI) by a height of 2 mm (Group E [elevation]), and the margin of the other side served as a control (Group NE [no elevation]). Lithium disilicate computer-aided design and computer-aided manufacturing (CAD/CAM) inlays were fabricated and bonded with a self-adhesive resin cement. An aging process was simulated on the specimens under thermomechanical cycling by using a chewing simulator. Marginal integration was evaluated under scanning electron miscroscopy (SEM) using epoxy resin replicas before and after cycling. Marginal areas were stained with silver nitrate solution, and the volumetric gap was measured at the bonded interfaces using micro-computed tomography (CT) before and after cycling. Statistical analyses were performed using paired t-tests, the Wilcoxon signed rank test, and the Mann–Whitney test (a&lt;0.05).

Results
SEM showed marginal discontinuities in Group NE that increased after thermomechanical cycling. Micro-computed tomography exhibited three-dimensional dye-penetrating patterns at the interfaces before and after cycling. Interfacial disintegration was larger in Group NE before cycling (p&lt;0.05). Thermomechanical cycling increased the gaps in both Groups NE and E (p&lt;0.05). The gap increment from thermomechanical cycling was larger in Group NE (p&lt;0.05).

Conclusions
Thermomechanical cycling induced interfacial disintegration at the lithium disilicate CAD/CAM inlays, with deep proximal margins. Margin elevation with RMGI placement reduced the extent of the interfacial gap formation before and after the aging simulation.
Familial nephropathy in Bracchi Italiani: 8 cases (2012–2019)
Authors: Inman Amanda L. , Allen-Durrance Ashley E. , Cianciolo Rachel E. , Harris Autumn N. 
Published: November 2021

Abstract

OBJECTIVE
To characterize the signalment, clinical signs, clinical pathological and histologic findings, and outcome in 8 related Bracchi Italiani with proteinuric kidney disease.

ANIMALS
8 client-owned Bracchi Italiani.

PROCEDURES
Health records submitted to the Bracco Italiano Health Foundation and the Bracco Italiano Club of America between 2012 and 2019 were reviewed for dogs with evidence of nephropathy for which histologic diagnoses were obtained. Pedigree, signalment, clinical signs, diagnostic test results (including microscopic examination of kidney tissue samples collected ante- or postmortem), and outcome were acquired. Results were presented as descriptive statistics.

RESULTS
The most common clinical sign in affected dogs was inappetence. All dogs were proteinuric, and 4 dogs were azotemic. Seven dogs developed clinical signs of kidney disease and were euthanized a median of 75 days postdiagnosis. Six dogs had glomerular amyloidosis, and 1 dog each had nephrosclerosis and nonamyloidotic fibrillar glomerulopathy.

CONCLUSIONS AND CLINICAL RELEVANCE
Results indicated that the clinical presentation may vary in affected dogs, and proteinuria in young or middle-aged Bracchi Italiani should raise the concern for hereditary nephropathy. Prognosis is likely poor once clinical signs are noted.
Comparison of bacteriologic culture results for skin wound swabs and skin wound biopsy specimens
Authors: Stokes Rebecca A. , Coleman Michelle C. , Rogovskyy Artem S. , Dickerson Vanna M. , Thieman Mankin Kelley M. 
Published: November 2021

Abstract

OBJECTIVE
To compare bacteriologic culture results for superficial swab and tissue biopsy specimens obtained from dogs with open skin wounds.

ANIMALS
52 client-owned dogs.

PROCEDURES
For each dog, 1 wound underwent routine preparation prior to collection of 2 specimens, 1 by superficial swab (Levine) technique and 1 by tissue biopsy. Specimens were processed for bacteriologic culture. Two observers determined whether any detected difference in culture results for the 2 types of specimen would have resulted in differing treatment plans.

RESULTS
Culture results of swab and tissue biopsy specimens were identical in 11/52 (21.2%) cases. Tissue biopsy specimen and swab cultures yielded positive results for 44 (84.6%) and 40 (76.9%) wounds, respectively. With regard to mean recovery rates of bacteria from wounds with positive culture results, both the biopsy specimens and swabs yielded 3.4 bacterial species/wound. All wounds for which swab cultures yielded no growth also had negative culture results for biopsy specimens. Biopsy specimen and swab culture results were in agreement with regard to the most common bacteria cultured. In 7/52 (13%) wounds, the observers would have treated the patient differently on the basis of the results of the 2 cultures.

CONCLUSIONS AND CLINICAL RELEVANCE
Results indicated that culture of a swab collected by the Levine technique is an appropriate noninvasive alternative to culture of a tissue biopsy specimen. A negative result obtained from culture of a swab is likely to be reliable. Disagreement between the results of swab and tissue biopsy specimen cultures is likely of low clinical importance.
Computed tomographic findings and clinical features in dogs with canine cutaneous lymphoma: 10 cases (2007–2018)
Authors: Watton Thom C. , Purzycka Katarzyna , Fitzgerald Ella 
Published: November 2021

Abstract

OBJECTIVE
To report clinical features, CT findings, treatment protocols, and outcomes for dogs in which canine cutaneous lymphoma (CCL) was diagnosed.

ANIMALS
10 client-owned dogs with CCL.

PROCEDURES
Medical records of dogs in which a diagnosis of CCL had been made between September 2007 and July 2018 and in which CT had been performed prior to treatment were reviewed. All available CT studies were reviewed, and an anatomical reference system was developed to map observed lesions. Treatment protocols and patient outcomes were summarized.

RESULTS
14 CT examinations were performed on the 10 dogs, and 9 dogs had lesions consistent with CCL on CT images. Nodular lesions were present in 8 dogs, and cutaneous or subcutaneous mass lesions were seen in 3. Well-defined, diffusely distributed, contrast-enhancing, cutaneous or subcutaneous nodules were most common; mass lesions were more variable in appearance. Nine dogs had lymphadenopathy, with the mandibular and axillary lymph nodes most commonly affected. Four dogs had confirmed nodal involvement, and 4 had confirmed visceral involvement. Nine dogs received treatment with chemotherapy, and 5 had a complete response.

CONCLUSIONS AND CLINICAL RELEVANCE
Results indicated that dogs with CCL may have a wide spectrum of CT findings. Many of these lesions, including affected lymph nodes, would be unlikely to be detected clinically, suggesting that CT may be a useful modality to assess the severity of disease and for guiding selection of local versus systemic treatment.
Pantheistic versus Participatory Christologies: A Critical Analysis of Richard Rohr’s Universal Christ in Light of Thomas Aquinas’s Commentary on John
Authors: Dauphinais Michael A. 
Published: November 2021

Abstract
This essay will present Richard Rohr’s central claims about Jesus Christ and the presence of God in creation and then consider them in light of Aquinas’s teachings with particular attention to his Commentary on John. This essay attempts to show that Rohr’s claims are incomplete and ultimately misguided and that Aquinas’s participatory account of creation and the Incarnation allows him to cultivate an awareness of God’s presence in all of creation while also maintaining the salvific uniqueness of the Incarnation.
Ein Wanderer und sein Schatten - Friedrich Nietzsches Gedanken-Gänge in St. Moritz
Authors: Wachendorff Elke Angelika 
Published: November 2021

Den Sommer 1879 verbrachte Nietzsche in St. Moritz. Hier passten Ort, Lage, Landschaft und Umfeld perfekt zu Nietzsches Lebenssituation, und hier entstand Der Wanderer und sein Schatten, das berühmt werden sollte. Die Autorin beschäftigt sich mit den besonderen Umständen, Einzelheiten, Besonderheiten – den Wechselwirkungen von Umfeld, Klima, Kuren, Diäten, Topographien und Gedanken – und thematisiert Momente und Impulse in der Entwicklung von Nietzsches Philosophieren, Auseinandersetzungen mit etablierten philosophischen Positionen und diversen Lektüren. Es geht ihr nicht um einen wissenschaftlichen Kommentar des entstandenen Werkes. Vielmehr will das Buch anregend und vertiefend neue Augen und Ohren für dessen Lektüre öffnen. Fotografien aus der Zeit ermöglichen das atmosphärische Eintauchen in Nietzsches Sommer in St. Moritz.
Écrire Juliette Ernst - Bibliographie et sciences de l’Antiquité au XXe siècle
Authors: Hilbold Ilse 
Published: November 2021

Née en 1900 à Alger, Juliette Ernst a été la rédactrice, puis la directrice de L’Année Philologique de 1929 jusqu’aux années 1990. Débutant son travail à L’APh aux côtés de Jules Marouzeau, qui en avait été le fondateur en 1926, Juliette Ernst participe au processus de modernisation de la bibliographie qui traverse alors toutes les sciences et que soutient la Société des Nations. Juliette Ernst a ensuite suivi Jules Marouzeau dans un autre projet d’envergure internationale, la Fédération Internationale des associations d’Études Classiques, où elle œuvre comme secrétaire depuis sa fondation, en 1948, jusqu’en 1974. Avec ses deux carrières, elle dévoile en fait un même domaine de compétences, que l’on peut résumer par la fabrique des relations internationales entre spécialistes des sciences de l’Antiquité.
Cette enquête retrace l’histoire de ces deux outils de coopération internationale que Juliette Ernst a su conjuguer des décennies durant au profit des antiquisants du monde entier.
Preliminary Assessment of the Soil Foundation Characteristics Utilizing the 2D Resistivity Imaging and Down-Hole Seismic Refraction Techniques: A Case Study in Tenth of Ramadan City, Egypt
Authors: Soliman Shokry A. , Shebl Salah , El Khafif Ahmed , Hazley T.F. S , Farag M.H. 
Published: November 2021

Two-dimensional electrical resistivity imaging and seismic refraction, in the form of down-hole survey, were applied to delineate the subsurface section and elastic moduli and identify geotechnical characteristics of subsurface materials in the 10th of Ramadan industrial area, Cairo, Egypt. The results of four 2-D profiles of electrical resistivity, in the form of dipole–dipole and Wenner configurations, revealed that the subsurface section contains two main geo-electrical layers; the first is made of sand, some silt, and gravels, reflecting low resistivity values ranging from 25 to 65.5 ohm m. This layer is overlying a high resistivity layer (65.5 to135 ohm m), corresponding to medium to coarse sand, with gravel and calcareous materials. It is worth noting that that the down-hole technique was used to measure velocities of P and S waves in order to derive the low strain dynamic elastic properties, such as Poisson’s ratio, Shear modulus, stress ratio, concentration index, N-value, and the ultimate and allowable bearing capacities of the subsurface soil, down to an approximate depth of 30 m in the borehole at the site. In addition, the Vs30 value was calculated and revealed that the soil is categorized as a NEHRP class (D). Furthermore, the results of geotechnical parameters and elastic moduli were found to be realistic and sensible for the purposes of engineering constructions and imply that the soil in the study area is characterized by fairly to moderately competent quality. A new empirical correlation is proposed between the obtained Vs and resistivity values, where Vs = 1.0302 ρ + 172.74.
Density - Velocity Relationship and Prediction of Lithology Variation Using Physical Analysis in Kf-4 Well of The Kifl Oil Field, Yamama Formation, South of Iraq
Authors: Alobaidy Abdulaziz R. , Al-Banna Ahmed S. 
Published: November 2021

The density-velocity relation is an important tool used to predict one of these two parameters from the other. A new empirical density –velocity equation was derived in Kf-4 well at Kifl Oil Field, south of Iraq. The density was derived from Gardner equation and the results obtained were compared with the density log (ROHB) in Kl-4 well. The petrophysical analysis was used to predict the variations in lithology of Yamama Formation depending on the well logs data, such as density, gamma, and neutron logs. The physical analysis of rocks depended on the density, Vp, and Vs values to estimate the elastic parameters, i.e. acoustic impedance (AI) and Vp/Vs ratio, to predict the lithology and hydrocarbon indicators. According to the results of physical properties, Yamama Formation is divided into five units in Kf-4 well at Kifl Oil Field. The lithology of Yamama Formation was found to consist of limestone, dolomite, shale, and anhydrite rocks.
Magnetic and Transport Studies of Strongly Correlated Perovskite Ceramics
Authors:   , Hemery Erwan 
Published: November 2021

<p>This thesis describes the results from an experimental study of the magnetic and transport properties of two strongly correlated transition metal oxides. The firstmaterial under study is the ferromagnetic half-metal double perovskite, Sr2FeMoO6, in which we have made isoelectronic (Ba2+) and electronic (La3+) substitutions onto the strontium site. Magnetoresistance measurements on Sr2-xBaxFeMoO6 revealed that the low temperature magnetoresistance is dominated by inter-grain transport while the intra-grain contribution is evident when the temperature is close to the ferromagnetic transition temperature. Transport measurements on Sr2-xLaxFeMoO6 clearly showed that the doping dependence of the thermoelectric power is surprisingly similar to the one observed in the superconducting cuprates. In addition, it was found that the electronic doping leads to an increase in the ferromagnetic transition temperature, which supports the band filling model. Substitution on the Fe site was also investigated by partially replacing Fe with the non-magnetic aluminium element (Sr2Fe1-xAlxMoO6). It was found from thermoelectric power measurement that the Fe electronic state is below3+,which is inconsistentwith theoretical models but is in good agreement with Mossbauer measurements. In addition, magnetic measurements showed that the reduction in the ferromagnetic ordering temperature could be explained in terms of a 3D percolation model. The second compound is the oxygen deficient strontium iron oxide SrFeO3-delta . The temperature dependence of the thermoelectric power was measured in this compound for the first time and shown to be reminiscent of the charge-ordering Verwey transition observed in Fe3O4. Magnetic measurements show an increase of a weak ferromagnetic signal versus the oxygen deficiency that could originate from a Dzyaloshinsky-Moriya interaction in the distorted FeO6 octahedra. Finally, we observed a large magnetoresistance near room temperature for compounds close to the orthorhombic SrFeO2.75 phase.</p>