bluuebunny/crossref_metadata_2025_split huggingface dataset:
A simulation study of nonideal mixing effect on the dynamic response of an exothermic CSTR with Cholette’s model
Authors: Yang Chane-Yuan , Chien Yu-Shu , Chou Jun-Hong 
Published: August 2021

Abstract
The study of nonideal mixing effect on the dynamic behaviors of CSTRs has very rarely been published in the literature. In this work, Cholette’s model is employed to explore the nonideal mixing effect on the dynamic response of a nonisothermal CSTR. The analysis shows that the mixing parameter n (the fraction of the feed entering the zone of perfect mixing) and m (the fraction of the total volume of the reactor), indeed affect the characteristic roots of transfer function of a real CSTR, which determine the system stability. On the other hand, the inverse response and overshoot response are also affected by the nonideal mixing in a nonisothemal CSTR. These results are of much help for the design and control of a real CSTR.
Theory of chaos synchronization and quasi-period synchronization of an all optic 2n-D LAN
Authors: Senlin Yan 
Published: August 2021

AbstractTheory of chaos synchronization and quasi-period synchronization of an all optics local area network (O-LAN) is deeply studied and discussed, where two coupled-lasers are used as network’s double-star and the other single-lasers are used as network nodes. The LAN operates double-star lasers to drive node lasers in two links to perform a 2n−D (n is a positive integer, dimensions (D)) laser network. The O-LAN has the characteristics of an all optics LAN with double-center and two link nodes. Our theoretical and numerical results prove that the double-center lasers can obtain their synchronizations with each laser in two link nodes. A route to chaos after a quasi-period bifurcation is analyzed to illustrate dynamics distribution region of O-LAN. We find five quasi-period regions, four chaos regions, where there is a region where instability mixes with the first chaos, and a stable region. We find also that O-LAN can obtain its parallel multi-dynamics synchronizations, such as cycle-one synchronization, cycle-2 synchronization, cycle-3 synchronization, cycle-4 synchronization, cycle-5 synchronization, other quasi-period synchronization and chaos synchronization, shown in two links of O-LAN by shifting the currents of the lasers in one link. The theory of all optics LAN and its obtained results are useful to study on complex dynamic system, optics network, artificial intelligence, chaos and its synchronization.
The Concept of State in Kierkegaard’s Papers
Authors: Wende Matías Tapia 
Published: August 2021

Abstract
In this paper, I aim to show the evolution of Kierkegaard’s views on the state scattered in his Papers. To do this, I will carry out an analysis divided into chronological periods, and I will characterize each period in terms of its main features. The goal is to give a comprehensive account of Kierkegaard as a champion of the monarchical and authoritative state, who loses his patience and attacks the established order only when he thinks that Christianity’s truth is at the greatest risk. This interpretation contrasts both with a mere despotic Kierkegaard and with a more liberal one.
The Liberating Cacophony of Feelings: Kierkegaard on Emotions
Authors: Rosfort René 
Published: August 2021

Abstract
This article argues that Kierkegaard’s account of emotions has something important to contribute to contemporary philosophy of emotions. The argument proceeds in five steps. The first section starts by outlining two influential paradigms in contemporary philosophy of emotions: the feeling theories and the cognitive theories. The second section then turns to a critique of two prominent approaches that read Kierkegaard’s conception of emotions as belonging to the cognitive theories. The third section presents Kierkegaard as a phenomenologist of emotional ambiguity, while the fourth section attempts to outline a taxonomy of Kierkegaard’s phenomenology of emotional experience. The fifth and final section argues that Kierkegaard’s primary contribution to contemporary philosophy of emotions is to be found in his concept of anxiety as the experience of human freedom particularly with respect to the ambiguity of feeling and understanding characteristic of this fundamental affective phenomenon.
The (Im)proper Community: On the Concept of Eiendommelighed in Kierkegaard
Authors: Lysemose Kasper 
Published: August 2021

Abstract
The aim of the paper is to demonstrate that the concept of Eiendommelighed in Kierkegaard has a considerable philosophical weight, although it figures only marginally. It is emphasized that Kierkegaard—well ahead of the deconstruction of community in contemporary philosophy—creates a concept by which the complicity of singularity and community becomes evident. The gist of the concept is an indistinction between the proper and the improper. Eiendommelighed is that by which singularities, or neighbors, are called into the inappropriability of their ownmost being. This call is then recalled between neighbors who in this way form an (im)proper community.
Lukács and Kierkegaard: Decadence or Despair
Authors: Hannay Alastair 
Published: August 2021

Abstract
A distrust of focus on subjectivity and the individual provoked by his meeting with Sartrean existentialism led György Lukács to turn his early but qualified admiration of Søren Kierkegaard into an accusation of fostering a bourgeois culture of the kind Kierkegaard is usually thought to have opposed. Not every Marxian thinker has been equally wary of subjectivity, but all have found in Kierkegaard a crucial absence of concern for human exploitation within a context of natural scarcity. However, a more measured reading suggests a case for resolving the need to choose between Lukács’s insistence on “spirit” as a collective notion and Kierkegaard’s as cultivation of a trans-historically oriented, self-stabilizing social will.
„Die Grundlagen der Lehre der Russischen Orthodoxen Kirche über Würde, Freiheit und Rechte des Menschen“ (2008). Eine Debatte
Authors: Wasmuth Jennifer 
Published: August 2021

Zusammenfassung
In dem Beitrag werden das 2008 von der Bischofssynode der Russischen Orthodoxen Kirche verabschiedete Dokument „Die Grundlagen der Lehre der Russischen Orthodoxen Kirche über Würde, Freiheit und Rechte des Menschen“ sowie die darauf erfolgende Antwort der Gemeinschaft Evangelischer Kirchen in Europa in ihren wesentlichen inhaltlichen Aussagen vorgestellt und die sich aus beiden Dokumenten ergebende kirchliche wie wissenschaftliche Debatte skizziert.
Die Russische Orthodoxe Kirche und die Menschenrechte – Beobachtungen zum Hintergrund ihrer Position
Authors: Kadotschnikow Ernest 
Published: August 2021

Zusammenfassung
In den Stellungnahmen von Vertretern der Russischen Orthodoxen Kirche zu den Menschenrechten finden sich ambivalente Aussagen, die eher in Richtung von Befremden und Kritik tendieren. Die Menschenrechte sind demnach ein Konzept des häretischen, aufgeklärten und somit gottlosen Westens, das den Menschen anstelle von Gott in den Mittelpunkt stellt und die Rechte der Gemeinschaft gegenüber dem Individuum sowie die traditionelle Familie gefährdet. Vertreter der Russischen Orthodoxen Kirche berufen sich jedoch auf die Menschenrechte, wenn sie glauben, dass die Kirche davon profitiert. Dieser Artikel beleuchtet die Hintergründe, weshalb sie häufig keinen Anlass sehen, die für die Kirche positiven Seiten der Menschenrechte zu erkennen.
Ökumenische und politische Konvergenzen in Bezug auf die Menschenrechte
Authors: Hallensleben Barbara 
Published: August 2021

Zusammenfassung
Das Dokument der Russischen Orthodoxen Kirche über „Würde, Freiheit und Rechte des Menschen“ (2008) löste eine eher polemische Debatte aus. Der kürzlich durch das Ökumenische Patriarchat von Konstantinopel approbierte Text „Für das Leben der Welt. Auf dem Weg zu einem Sozialethos der Orthodoxen Kirche“ (2020) wirft neues Licht auf die damalige Auseinandersetzung und eröffnet Perspektiven einer ökumenischen Konvergenz über die Menschenrechte.
Prognostic value of microRNA-4521 in non-small cell lung cancer and its regulatory effect on tumor progression
Authors: Sun Butong , Cong Dan , Chen Kang , Bai Yuansong , Li Jun 
Published: August 2021

Abstract

Background
Non-small cell lung cancer (NSCLC) is a malignant tumor with the highest mortality rate in our country. It has been found in many studies that microRNA-4521 (miR-4521) is abnormally expressed and plays a role in clear cell renal cell carcinoma and other cancers.

Objective
The purpose of this study was to explore the relationship between miR-4521 expression and clinical prognosis, as well as its influence on cell biological behavior.

Methods
The expression differences of miR-4521 in NSCLC tissues and cells were examined by qRT-PCR technology. Kaplan–Meier survival analysis and Cox regression analysis were used to analyze the clinical information and survival status of patients to explore the relationship. Using the vitro cell MTT assay, Transwell assay, and western-blot analysis, the effects of miR-4521 on cell proliferation, migration, and invasion were analyzed.

Results
The expression of miR-4521 in NSCLC tissues and cells was significantly downregulated. miR-4521 can be used as an independent prognostic factor. The survival rate of the miR-4521 low expression group was lower, which was significantly related to poor prognosis. In addition, the low expression of miR-4521 significantly promoted cell proliferation, migration, and invasion with highly expressed related protein levels. FOXM1 might be a direct target of miR-4521.

Conclusion
The results of this study showed that the low expression of miR-4521 indicated the poor prognosis of NSCLC and promoted cell proliferation, migration, and invasion by targeting FOXM1.
Small cell lung cancer transformation during antitumor therapies: A systematic review
Authors: Chai Xing , Zhang Xinru , Li Wenqian , Chai Jin 
Published: August 2021

Abstract
Lung cancer is the most common cause of cancer-related death. Non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) are the two major histological categories of lung cancers. Drug resistance is a great challenge for cancer treatment, and histological transformation from NSCLC to SCLC is one of the mechanisms underlying drug resistance in NSCLC patients. SCLC-transformed patients show combined characteristics of NSCLC and SCLC; however, they lack timely diagnoses and effective treatment strategies. Thus, we reviewed the clinical characteristics of SCLC transformation patients with a literature search to enhance clinical consciousness, diagnosis, and personalized treatment for patients with it.
Tribological properties of organotin compound modified UHMWPE
Authors: Yang Tian , Xu Haiping , Jin Yongliang , Huang Ke , Tu Jiesong , Jia Dan , Zhan Shengpeng , Ma Lixin , Duan Haitao 
Published: August 2021

AbstractA range of ultra-high molecular weight polyethylene (UHMWPE)/tetraphenyltin (Ph4Sn) nanocomposites were fabricated by hot-pressing. The surface hardness and crystallinity of composites were studied. It revealed that the surface hardness of the composites decreased slightly, and the changing trend of crystallinity was consistent with the hardness. The tribological properties of composites under seawater lubricating conditions were investigated. The experimental results showed that the friction coefficients of the composites almost keep the same but the wear reduced sharply. With the increases of Ph4Sn content, the wear of composites first decreases significantly and then increases, meanwhile the friction coefficient remains basically unchanged. The dominant wear mechanism has changed from adhesive wear to plastic deformation and finally to abrasive wear. The addition of Ph4Sn particles reduces the sensitivity of the Ph4Sn/UHMWPE composites to water and transfers the load to the UHMWPE network, resulting in the wear resistance improved.
Reglementierte Berufe: Einordnung der Länderempfehlungen der Europäischen Kommission zum Reformbedarf des Regulierungsrahmens in Deutschland
Authors: Recker Clemens 
Published: August 2021

Abstract
In its country-specific recommendations for Germany, the European Commission regularly calls for reform in the area of regulated professions. These reform demands focus in particular on the business-related services provided by lawyers, tax advisors, auditors, architects or civil engineers. In doing so, the Commission pursues the thesis that the protection of similar general interests in the case of the domestic regulatory approach with binding professional access rules and a mandatory chamber system is accompanied by a comparatively high regulatory intensity and unnecessarily restricts competition. The Commission bases this assumption on different direct and indirect regulatory and competition indicators. This paper provides an overview of the strengths and weaknesses of these indicators and concludes that these do not allow for a robust conclusion on below-average competition intensity in professional services in Germany.
Actitudes de estudiantes de una universidad pública sobre la aplicación del aprendizaje invertido
Authors: Chambi-Mescco Edith 
Published: August 2021

El enfoque denominado aprendizaje invertido ha estado llamando la atención del personal docente en los últimos años, debido a su novedosa forma de programar y ejecutar las sesiones de aprendizaje, lo que ha marcado una diferencia con el modelo tradicional. Se ha aplicado este enfoque en diversos programas de educación superior, los resultados expresan los logros que se han obtenido en términos de aprendizaje. El objetivo del presente artículo de investigación es identificar las actitudes que tiene el estudiantado de segundo ciclo de estudios generales de una universidad pública peruana, luego de haber experimentado el aprendizaje invertido en la asignatura de Lenguaje y Comunicación, en el semestre académico 2018-II. Este estudio es cuasiexperimental y de enfoque mixto. Se aplicó un cuestionario, elaborado por Farrah y Qawasmeh (2018), para recoger las actitudes de 70 estudiantes de dos aulas y que llevaron el curso dirigido por el mismo docente. Los resultados indican que el estudiantado considera que el enfoque pedagógico aprendizaje invertido es altamente beneficioso para sus aprendizajes y sugieren que su eficacia depende de la autonomía que tenga el estudiantado para desarrollar las actividades previas y de las facilidades que tengan para acceder a internet.
Alpha variant (B.1.1.7) of SARS-CoV-2 increases fatality-rate for patients under age of 70 years and hospitalization risk overall
Authors: Cetin Meryem , Balci Pervin Ozlem , Sivgin Hakan , Cetin Sirin , Ulgen Ayse , Dörtok Demir Hatice , Li Wentian 
Published: August 2021

AbstractThe emergence of new SARS-CoV-2 variants is a challenge to the control of this pandemic. It is therefore important to collect and to analyze data related to the infection caused by different variants. We have obtained more than 3,700 COVID-19 patients between April 2020 and March 2021 from Tokat, Turkey (roughly 3,100 outpatients and close to 600 inpatients) where about 30% were infected with Alpha variant (B.1.1.7). Descriptive statistics was used to characterize different subgroups. Both logistic regression and cause-specific Cox survival analysis of competing-risk was run on inpatients, to examine the impact of Alpha variant on hospitalization, on mortality and on other factors. We observed that the Alpha variant is over-represented in inpatients than outpatients so infection by Alpha variant increases the chance for hospitalization. The impact of Alpha variant on mortality seems to depend on the patient's age. For patients under age of 70, the case-fatality-rate was 0.84% (5.3%) for patients without (with) Alpha variant (Fisher's test P-value = 2.4 × 10−10). For patients above age of 70, the trend is opposite: the case-fatality-rate is 31.5% (13.6%) for patients without (with) Alpha variant (Fisher's test P-value = 0.0016). The two opposite trends would cancel each other, making other analyses such as cause-specific Cox regression and logistic regression non-significant. The Alpha variant increases the risk for hospitalization, increases the case-fatality-rate for lower age group, and decreases the case-fatality-rate for the upper age group. If the increase of case-fatality-rate in not the most senior group holds true, it should provide useful information for a vaccination planning to counter the impact of Alpha variants.
ANALISIS KEBUTUHAN PENGEMBANGAN BUKU AJAR BIOTEKNOLOGI BERBASIS HASIL PENELITIAN PADA MATERI DNA FORENSIK
Authors: Iza Nikmatul , Sari Nila Kartika 
Published: August 2021

Abstract: This study analyzes textbooks based on research in biotechnology courses related to the principles of Forensic DNA discussion that need to be developed. The research method used in the development model Hanafin Peck (1988) at the beginning of the needs analysis. Research subjects were 45 biology education students who had taken Biotechnology courses. The instrument used consisted of a questionnaire distributed to students and lecturers supporting biotechnology courses and interview techniques. The results showed that in the learning process do not use textbooks and as much as 94% of students need the development of textbooks that are equipped with interesting pictures and practicum guides in them. Research results, so that the learning process becomes more directed, contextual and enjoyable Abstrak: Penelitian ini bertujuan menganalisis buku ajar berbasis hasil penelitian pada matakuliah bioteknologi terkait dengan pokok bahasan DNA Forensik yang perlu dikembangkan. Metode penelitian yang digunakan merujuk pada model pengembangan Hanafin Peck (1988) pada tahap awal yaitu analisis kebutuhan. Subjek penelitian adalah 45 mahasiswa pendidikan biologi yang telah mengambil matakuliah Bioteknologi. Instrumen yang digunakan berupa angket yang disebarkan kepada mahasiswa dan dosen pengampu matakuliah bioteknologi serta teknik wawancara. Hasil penelitian menunjukkan bahwa dalam proses pembelajaran belum menggunakan buku ajar dan sebanyak 94% mahasiswa menginginkan pengembangan buku ajar yang dilengkapi dengan gambar yang menarik dan petujuk praktikum yang didalamnya memuat hasil penelitian, sehingga proses pembelajaran menjadi lebih terarah, kontekstual dan menyenangkan.
ANALISIS KEBUTUHAN BUKU AJAR PERKEMBANGAN HEWAN BERBASIS MODEL REACT (RELATING, EXPERIENCING, APPLYING, COOPERATING, TRANSFERING)
Authors: Sari Nila Kartika , Iza Nikmatul 
Published: August 2021

Abstrak: Penelitian ini bertujuan untuk menganalisis kebutuhan buku ajar Animal Development Berbasis model REACT yaitu Relating (mengaitkan), Experiencing (mengalami), Applying (menerapkan), Cooperating (Bekerjasama), Transferring (mentransfer). Metode analisis kebutuhan telah dilakukan dengan menggunakan model pengembangan 4D Thiagarajan hingga tahap pendefinisian (define).. Subjek penelitian yaitu mahasiswa Pendidikan Biologi IKIP Budi Utomo Malang yang telah menempuh matakuliah perkembangan hewan sebanyak 40 orang. Teknik pengumpulan data yang dilakukan dengan observasi, angket kepada mahasiswa dan dosen. Hasil belajar berdasarkan angket menunjukkan bahwa sumber belajar yang kurang relevan. 75 persen mahasiswa masih kesulitan mengikuti perkuliahan, sehingga 100 persen mahasiswa setuju setuju dan menyatakan perlu dikembangkan buku ajar perkembangan Hewan Berbasis model REACT. Hasil analisis kebutuhan untuk dosen pengampu matakuliah perkembangan hewan menyatakan bahwa sangat perlu dikembangkan buku ajar berbasis model REACT khususnya materi pembelahan sel karena model ini mampu memberdayakan kemampuan berpikir mahasiswa dan dapat melatih pembelajaran mandiri dalam memahami materi perkembangan hewan. Abstract: This study aims to analyze the requirement Animal Development textbooks based on the REACT model, namely Relating, Experiencing, Applying, Cooperating, Transferring. The method of analyzing needs has been done by Thiagarajan's 4D development model to the defining stage. The research subjects were students of Biology Education IKIP Budi Utomo Malang who had taken animal development courses as many as 40 people. Data collection techniques carried out by observing, conducting questionnaires to students and lecturers the result of the study based on questionaire showed that the lack of relevant learning resources. 75 percent students still had difficulty attending lectures, Moreover 100 percent students agreed to use a textbook based on the development of Animal-Based REACT models. The results of the analysis of the need for lecturers supporting animal development courses states that it is very necessary to develop textbooks based on the REACT model especially cell division material because this model can empower students' thinking abilities and can practice independent learning in understanding animal development material.
PENGEMBANGAN MEDIA iSPRING SUITE 8 DENGAN MODEL THINK PADA MATA KULIAH GENETIKA
Authors: Qomariah Ismi Nurul , Mistianah Mistianah 
Published: August 2021

Abstrak. Penelitian ini bertujuan untuk mengembangkan model pembelajaran Think berbasis media I Spring suite 8 bagi mahasiswa Pendidikan Biologi. Jenis penelitian ini adalah Research and Development. Pengembangan media pembelajaran menggunakan metode Research and Development (R & D) dengan model 4 D (Define, Design, Develop, dan Dessiminate). Penelitian ini dimulai dari tahap define yaitu mengidentifikasi konsep-konsep material yang harus terkandung dalam media. Mendesain lebih lanjut model pembelajaran Think berbasis media pembelajaran I Spring suite 8. Setelah media dirancang dan dibuat maka dilakukan tahap pengembangan yaitu validasi produk oleh ahli dan uji coba produk pada proses perkuliahan. Hasil penelitian menunjukkan bahwa validitas ahli materi dalam kriteria valid dengan persentase 88 persen, hasil validitas ahli media dalam kriteria valid dengan persentase media pembelajaran sebesar 89 persen. Dari uji kelayakan diperoleh hasil uji kelayakan. Disimpulkan bahwa media termasuk dalam kategori sangat baik.Asbtract. This study aims to develop I Spring suite 8 learning media based Think learning model for Biology Education college students. The type of this research was Research and Development. The development of learning media uses the Research and Development (R & D) method with the 4 D model (Define, Design, Develop, and Dessiminate). This research starts from the define stage that was identificatethe material concepts that must be contained in media. Furthermoredesign the I Spring suite 8 learning media based Think learning model. After media has been designed and created, the development stage was carried out, namely product validation by experts and product testing in the lecture process. The results showed that the validity of the material experts was in valid criteria with the percentage of 88 percent, the results of validity by media experts were in valid criteria with the percentage of learning media as much as 89percent. From the feasibility test, it was concluded that the media is included in the categoryvery good.