bluuebunny/crossref_metadata_2025_split huggingface dataset:
UPAYA PENINGKATAN PENGETAHUAN IBU HAMIL TENTANG TANDA BAHAYA KEHAMILAN DALAM MENGHADAPI PROSES PERSALINAN YANG AMAN
Authors: Handayani Ririn 
Published: April 2021

Upaya penurunan AKI membutuhkan aksi pada beragam level. Selain posyandu, kelas ibu hamil juga dianggap sebagai kelas yang paling efektif untuk meningkatkan pengetahuan ibu hamil dalam mengenali risiko dan tanda bahaya selama masa kehamilan serta sebagai sarana penting untuk merubah sikap dan perilaku ibu hamil. Dengan adanya kelas ibu hamil ini diharapkan seluruh ibu hamil dapat memiliki kemampuan melakukan deteksi dini tanda bahaya kehamilan sehingga ibu hamil dapat dengan nyaman melakukan proses persalinan tanpa ada kekhawatiran terhadap proses persalinan yang dihadapi dan secara tidak langsung dapat menurunkan angka kematian ibu. Salah satu faktor resiko yang juga menyumbang tingginya angka kematian ibu adalah persalinan yang ditolong oleh dukun dan ibu hamil dengan resiko tinggi. Hasil wawancara dengan bidan penanggung jawab di Desa Suco didapatkan informasi bahwa dalam satu tahun terahir terdapat ibu hamil yang melahirkan didukun tanpa pengawasan oleh tenaga kesehatan atau bidan. Beberapa ibu cenderung menarik diri dari petugas kesehatan dikarenakan faktor sosial ekonomi dan ketidaktahuan dari ibu hamil tentang tanda bahaya pada kehamilan dan saat proses persalinan. Desa Suco ini merupakan desa yang berada di wilayah kerja Puskesmas Mumbulsari Kabupaten Jember. Kelas ibu hamil merupakan kelompok khusus ibu hamil yang rutin diselenggarakan di Desa Suco. Melalui kegiatan tersebut, peneliti ingin memberikan pendidikan kesehatan kepada masyarakat khususnya ibu hamil tentang deteksi dini tanda bahaya dalam kehamilan dalam rangka persiapan proses persalinan yang aman dan sebagai upaya untuk menurunkan angka kematian ibu.
A utilização do Formulários Google como ferramenta de avaliação no processo de ensino e aprendizagem em tempos de pandemia de Covid-19: Um estudo em uma escola de educação básica
Authors: Dias Gustavo Nogueira , Silva Pedro Roberto Sousa da , Pamplona Vanessa Mayara Souza , Araújo Jamile Carla Oliveira , Barbosa Eldilene da Silva , Lobato Fabricio da Silva , Souza Júnior José Carlos Barros de , Silva Junior Washington Luiz Pedrosa da , Vogado Gilberto Emanoel Reis , Barreto Wagner Davy Lucas , Leal Ana Paula Ignácio Pontes , Silva Junior Ademir Ferreira , Pinto Gerson Pompeu 
Published: April 2021

A pesquisa: A utilização do Formulários Google como ferramenta de avaliação no processo de ensino e aprendizagem em tempos de pandemia de Covid-19, mostrou um estudo descritivo, transversal realizado com alunos do ensino médio de uma escola pública, da cidade de Belém do Pará, frente à utilização do Google forms, como instrumento de avaliação realizado do período de 01 de abril de 2020 até 15 de janeiro de 2021. Observou-se um significativo aumento da utilização das ferramentas tecnológicas utilizadas na educação a fim de suprir o fomento educacional e dar suporte aos estabelecimentos de instrução, em todas as esferas de ensinos. A proposta de utilização do Google Forms como instrumento avaliativo, tornou-se uma ferramenta indispensável, porém algumas restrições foram encontradas. O objetivo do presente estudo é descrever a utilização da ferramenta google forms como instrumento de avaliação com alunos da educação básica em tempos de pandemia da covid-19. Foi observado problemas que afetam o desenvolvimento educacional, como saúde mental e a desigualdade pela falta de acesso aos meios tecnológicos necessários a manutenção da educação além da vulnerabilidade social enfrentada por inúmeros alunos.
Faculty and Student Perceptions of Academic Integrity in Technology-Assisted Learning and Testing
Authors: Alessio Helaine Mary , Messinger Jeff D. 
Published: April 2021

The recent COVID-19 pandemic presented challenges to faculty (Fac) and students (Stu) to uphold academic integrity when many classes transitioned from traditional to remote. This study compared Fac and Stu perceptions surrounding academic integrity when using technology assisted proctoring in online testing.Methods: College Fac (N = 150) and Stu (N = 78) completed a survey about perceptions of academic integrity and use of proctoring software for online testing. Wilcoxon rank-sum tests were used to determine if there were differences in the distribution of agreement between students and faculty.Results: Fac and Stu agreed maintaining academic integrity was a priority (93 vs. 94%), and that it is easier to cheat in online tests (81 vs. 83%). Responses differed on whether online proctoring software was effective at preventing academic dishonesty (23% of Fac vs. 42% of Stu disagreed). 53% of Fac and 70% of Stu perceived that online proctoring was an invasion of privacy. Only 7% of Stu and 49% of Fac perceived importance in having a policy about proctoring online tests, whether cheating in an academic setting is likely associated with cheating in a work setting (78 vs. 51%), and if given a choice, 46% of Fac and only 2% of Stu would choose to use proctoring software. Answers to open-ended questions identified feelings of stress and anxiety by Stu and concerns about privacy by Fac.Conclusion: Fac and Stu had similar perceptions of the importance of academic integrity and ease of cheating in online tests. They differed in perception of proctoring software’s effectiveness in deterring cheating, choosing to give or take a proctored online test, and having a policy in place. Policies on technology-assisted online testing should be developed with faculty and student input to address student concerns of privacy, anxiety, and stress and uphold academic integrity.
A Prognostic Model Based on the Immune-Related lncRNAs in Colorectal Cancer
Authors: Qin Fengxia , Xu Houxi , Wei Guoli , Ji Yi , Yu Jialin , Hu Canhong , Yuan Chunyi , Ma Yuzhu , Qian Jun , Li Lingchang , Huo Jiege 
Published: April 2021

BackgroundColorectal cancer (CRC) is one of the most common malignant tumors with a poor prognosis. At present, the pathogenesis is not completely clear. Therefore, finding reliable prognostic indicators for CRC is of important clinical significance. In this study, bioinformatics methods were used to screen the prognostic immune-related lncRNAs of CRC, and a prognostic risk scoring model based on immune-related lncRNAs signatures were constructed to provide a basis for prognostic evaluation and immunotherapy of CRC patients.MethodsThe clinical information and RNA-seq data of CRC patients were obtained from The Cancer Genome Atlas (TCGA) database. The information of immune-related lncRNA was downloaded from the immunology database and analysis portal. The differentially expressed immune-related lncRNAs (IRLs) were screened by the edgeR package of R software. The prognostic value of IRLs was studied. Based on Cox regression analysis, a prognostic index (IRLPI) based on IRLs was established, and the relationship between the risk score and the clinicopathological characteristics of CRC was analyzed to determine the effectiveness of the risk score model as an independent prognostic factor.ResultsA total of 240 differentially expressed IRLs were identified between normal colorectal cancer tissues and normal colorectal cancer tissues, in which 8 were significantly associated with the survival of CRC patients (P &lt; 0.05), including LINC00461, LINC01055, ELFN1-AS1, LMO7-AS1, CYP4A22-AS1, AC079612.1, LINC01351, and MIR31HG. And most of the lncRNAs related to survival were risk factors for the prognosis of CRC. The index established based on the 7 survival-related IRLs found to be highly accurate in monitoring CRC prognosis. Besides, IRLPI was significantly correlated with a variety of pathological factors and immune cell infiltration.ConclusionEight immune-related lncRNAs closely related to the prognosis of CRC patients were identified from the TCGA database. At the same time, an independent IRLPI was constructed, which may be helpful for clinicians to assess the prognosis of patients with CRC and to formulate individualized treatment plans.
Cellular Responses to the Efferocytosis of Apoptotic Cells
Authors: Yin Charles , Heit Bryan 
Published: April 2021

The rapid and efficient phagocytic clearance of apoptotic cells, termed efferocytosis, is a critical mechanism in the maintenance of tissue homeostasis. Removal of apoptotic cells through efferocytosis prevents secondary necrosis and the resultant inflammation caused by the release of intracellular contents. The importance of efferocytosis in homeostasis is underscored by the large number of inflammatory and autoimmune disorders, including atherosclerosis and systemic lupus erythematosus, that are characterized by defective apoptotic cell clearance. Although mechanistically similar to the phagocytic clearance of pathogens, efferocytosis differs from phagocytosis in that it is immunologically silent and induces a tissue repair response. Efferocytes face unique challenges resulting from the internalization of apoptotic cells, including degradation of the apoptotic cell, dealing with the extra metabolic load imposed by the processing of apoptotic cell contents, and the coordination of an anti-inflammatory, pro-tissue repair response. This review will discuss recent advances in our understanding of the cellular response to apoptotic cell uptake, including trafficking of apoptotic cell cargo and antigen presentation, signaling and transcriptional events initiated by efferocytosis, the coordination of an anti-inflammatory response and tissue repair, unique cellular metabolic responses and the role of efferocytosis in host defense. A better understanding of how efferocytic cells respond to apoptotic cell uptake will be critical in unraveling the complex connections between apoptotic cell removal and inflammation resolution and maintenance of tissue homeostasis.
The Association Between Glucocorticoid Administration and the Risk of Impaired Efficacy of Axicabtagene Ciloleucel Treatment: A Systematic Review
Authors: Sun Zhen , Xun RenDe , Liu MengSi , Wu XiaoQin , Qu HongTao 
Published: April 2021

BackgroundGlucocorticoid is one of the common and important strategies for the treatment of chimeric antigen receptor T (CAR-T) cell therapy-related toxicity. However, there has been a theoretical concern about whether glucocorticoids use can impact the expansion of CAR-T cells and thus impair its efficacy. Hence, we reviewed studies related to the Axicabtagene ciloleucel (Axi-cel), a first-class and widely used CAR-T cell product, to elucidate the association between glucocorticoids administration and efficacy of Axi-cel.MethodWe systematically searched PubMed, Embase, Web of Science, and Cochrane Library to identify studies of Axi-cel that used glucocorticoids as an intervention for the treatment of CAR-T cell-related adverse events and respectively evaluated any efficacy endpoints of intervention and controlled cohorts, published up to February 17, 2020. There were no restrictions on research type and language.ResultsA total of eight studies with 706 patients were identified in the systematic review. Except for one study found that high cumulative dose, prolonged duration and early use of glucocorticoids could shorten progression-free survival and/or overall survival, and another study that found a negative effect of glucocorticoids administration on overall survival in univariate analysis but disappeared in multivariate analysis, none of other studies observed a statistically significant association between glucocorticoids administration and progression-free survival, overall survival, complete response, and overall response rate.ConclusionOur study indicated that the association between glucocorticoids therapy and the efficacy of CAR-T cell may be affected by cumulative dose, duration, and timing. There is currently no robust evidence that glucocorticoids can damage the efficacy of CAR-T cell, but the early use of glucocorticoids should be cautiously recommended.
The Architecture of Circulating Immune Cells Is Dysregulated in People Living With HIV on Long Term Antiretroviral Treatment and Relates With Markers of the HIV-1 Reservoir, Cytomegalovirus, and Microbial Translocation
Authors: Van de Wijer Lisa , van der Heijden Wouter A. , Horst Rob ter , Jaeger Martin , Trypsteen Wim , Rutsaert Sofie , van Cranenbroek Bram , van Rijssen Esther , Joosten Irma , Joosten Leo , Vandekerckhove Linos , Schoofs Till , van Lunzen Jan , Netea Mihai G. , Koenen Hans J.P.M. , van der Ven André J.A.M. , de Mast Quirijn 
Published: April 2021

Long-term changes in the immune system of successfully treated people living with HIV (PLHIV) remain incompletely understood. In this study, we assessed 108 white blood cell (WBC) populations in a cohort of 211 PLHIV on stable antiretroviral therapy and in 56 HIV-uninfected controls using flow cytometry. We show that marked differences exist in T cell maturation and differentiation between PLHIV and HIV-uninfected controls: PLHIV had reduced percentages of CD4+ T cells and naïve T cells and increased percentages of CD8+ T cells, effector T cells, and T helper 17 (Th17) cells, together with increased Th17/regulatory T cell (Treg) ratios. PLHIV also exhibited altered B cell maturation with reduced percentages of memory B cells and increased numbers of plasmablasts. Determinants of the T and B cell composition in PLHIV included host factors (age, sex, and smoking), markers of the HIV reservoir, and CMV serostatus. Moreover, higher circulating Th17 percentages were associated with higher plasma concentrations of interleukin (IL) 6, soluble CD14, the gut homing chemokine CCL20, and intestinal fatty acid binding protein (IFABP). The changes in circulating lymphocytes translated into functional changes with reduced interferon (IFN)- γ responses of peripheral blood mononuclear cells to stimulation with Candida albicans and Mycobacterium tuberculosis. In conclusion, this comprehensive analysis confirms the importance of persistent abnormalities in the number and function of circulating immune cells in PLHIV on stable treatment.
Caring for People With Dementia Under COVID-19 Restrictions: A Pilot Study on Family Caregivers
Authors: Carbone Elena , Palumbo Rocco , Di Domenico Alberto , Vettor Silvia , Pavan Giorgio , Borella Erika 
Published: April 2021

IntroductionThe present pilot study examined to what extent the COVID-19 lockdown affected the behavioral and psychological symptoms of dementia (BPSD) in people with dementia and worsened their family caregivers’ distress. The associations between changes in the BPSD of relatives with dementia (RwD) and in their caregivers’ distress, and sense of social and emotional loneliness, and resilience were also investigated.Materials and MethodsThirty-five caregivers of RwD attending formal healthcare services before the COVID-19 lockdown volunteered for the study, and were interviewed by phone during the lockdown. Caregivers completed the NeuroPsychiatric Inventory (NPI) to assess their care recipients’ BPSD and their own distress, and two questionnaires assessing their social and emotional loneliness, and their resilience.ResultsNo clear changes emerged in either the BPSD of the RwD or the caregivers’ distress during lockdown compared with before the pandemic. Caregivers reporting more frequent and severe BPSD in their RwD before the lockdown scored higher on emotional loneliness. Those reporting more frequent and severe BPSD under lockdown, especially men and those taking care of RwD with more advanced dementia, scored higher on both social and emotional loneliness. A significant negative correlation also emerged between caregivers’ resilience and changes in their level of distress due to the lockdown, with female caregivers reporting greater resilience.DiscussionOur findings offer preliminary insight on the effects of loneliness and resilience, and on the influence of individual characteristics on the experience and consequences of informal caregiving for RwD in times of restrictions imposed by a pandemic.
Physiologic Characteristics of Hyperosmolar Therapy After Pediatric Traumatic Brain Injury
Authors: Wellard Jeffrey , Kuwabara Michael , Adelson P. David , Appavu Brian 
Published: April 2021

All work was performed at the Barrow Neurological Institute at Phoenix Children's Hospital.Objective: Investigate injury severity, neuroimaging, physiology, and outcomes with bolus hyperosmolar therapy (HT) of 3% hypertonic saline or mannitol.Methods: Retrospective cohort analysis was performed. Physiologic variables included intracranial pressure (ICP), arterial blood pressure (ABP), and heart rate (HR). Volume-pressure compensation (PVC) indices included ICP pulse amplitude (AMP) and correlation of AMP and ICP (RAP). Cerebrovascular pressure reactivity (CVPR) indices included pressure reactivity index (PRx), pulse amplitude index (PAx), wavelet PRx (wPRx), and correlation of AMP and cerebral perfusion pressure (RAC). Heart rate variability (HRV) indices included heart rate standard deviation (HRsd), heart rate root mean square of successive differences (HRrmssd) and low-high frequency ratio (LHF). Outcome was assessed using Glasgow Outcomes Scale Extended Pediatrics, 12-months post-injury. Generalized estimating equations was applied to investigate associations of physiologic changes and pre-treatment indices with HT efficacy. Repeated measures analysis of variance was applied to investigate changes after HT without intracranial hypertension (ICH). Wilcoxon rank-sum was applied to investigate HT responsiveness with age, injury severity, neuroimaging, and outcomes.Results: Thirty children received bolus HT. ICH reduction after HT was associated with reduced ICP (p = 0.0064), ABP (p = 0.0126), PRx (p = 0.0063), increased HRsd (p = 0.0408), and decreased pretreatment RAC (p = 0.0115) and wPRx (p = 0.0072). HT-responsive patients were older and had improved outcomes (p = 0.0394). HT without ICH was associated with increased ICP (P &lt; 0.0001) and ABP (P &lt; 0.0001), increases in all HRV indices and decreases in all PVC indices.Conclusion: After pediatric TBI, efficacious HT is associated with decreased ICP and ABP, pre-treatment indices suggesting efficient CVPR, and potentially improved outcomes.
Distinguishing Pseudoprogression From True Early Progression in Isocitrate Dehydrogenase Wild-Type Glioblastoma by Interrogating Clinical, Radiological, and Molecular Features
Authors: Li Mingxiao , Ren Xiaohui , Dong Gehong , Wang Jincheng , Jiang Haihui , Yang Chuanwei , Zhao Xuzhe , Zhu Qinghui , Cui Yong , Yu Kefu , Lin Song 
Published: April 2021

Background: Pseudoprogression (PsP) mimics true early progression (TeP) in conventional imaging, which poses a diagnostic challenge in glioblastoma (GBM) patients who undergo standard concurrent chemoradiation (CCRT). This study aimed to investigate whether perioperative markers could distinguish and predict PsP from TeP in de novo isocitrate dehydrogenase (IDH) wild-type GBM patients.Methods: New or progressive gadolinium-enhancing lesions that emerged within 12 weeks after CCRT were defined as early progression. Lesions that remained stable or spontaneously regressed were classified as PsP, otherwise persistently enlarged as TeP. Clinical, radiological, and molecular information were collected for further analysis. Patients in the early progression subgroup were divided into derivation and validation sets (7:3, according to operation date).Results: Among 234 consecutive cases enrolled in this retrospective study, the incidences of PsP, TeP, and neither patterns of progression (nP) were 26.1% (61/234), 37.6% (88/234), and 36.3% (85/234), respectively. In the early progression subgroup, univariate analysis demonstrated female (OR: 2.161, P = 0.026), gross total removal (GTR) of the tumor (OR: 6.571, P &lt; 001), located in the frontal lobe (OR: 2.561, P = 0.008), non-subventricular zone (SVZ) infringement (OR: 10.937, P &lt; 0.001), and methylated O-6-methylguanine-DNA methyltransferase (MGMT) promoter (mMGMTp) (OR: 9.737, P &lt; 0.001) were correlated with PsP, while GTR, non-SVZ infringement, and mMGMTp were further validated in multivariate analysis. Integrating quantitative MGMTp methylation levels from pyrosequencing, GTR, and non-SVZ infringement showed the best discriminative ability in the random forest model for derivation and validation set (AUC: 0.937, 0.911, respectively). Furthermore, a nomogram could effectively evaluate the importance of those markers in developing PsP (C-index: 0.916) and had a well-fitted calibration curve.Conclusion: Integrating those clinical, radiological, and molecular features provided a novel and robust method to distinguish PsP from TeP, which was crucial for subsequent clinical decision making, clinical trial enrollment, and prognostic assessment. By in-depth interrogation of perioperative markers, clinicians could distinguish PsP from TeP independent from advanced imaging.
3T DCE-MRI Radiomics Improves Predictive Models of Complete Response to Neoadjuvant Chemotherapy in Breast Cancer
Authors: Montemezzi Stefania , Benetti Giulio , Bisighin Maria Vittoria , Camera Lucia , Zerbato Chiara , Caumo Francesca , Fiorio Elena , Zanelli Sara , Zuffante Michele , Cavedon Carlo 
Published: April 2021

ObjectivesTo test whether 3T MRI radiomics of breast malignant lesions improves the performance of predictive models of complete response to neoadjuvant chemotherapy when added to other clinical, histological and radiological information.MethodsWomen who consecutively had pre-neoadjuvant chemotherapy (NAC) 3T DCE-MRI between January 2016 and October 2019 were retrospectively included in the study. 18F-FDG PET-CT and histological information obtained through lesion biopsy were also available. All patients underwent surgery and specimens were analyzed. Subjects were divided between complete responders (Pinder class 1i or 1ii) and non-complete responders to NAC. Geometric, first order or textural (higher order) radiomic features were extracted from pre-NAC MRI and feature reduction was performed. Five radiomic features were added to other available information to build predictive models of complete response to NAC using three different classifiers (logistic regression, support vector machines regression and random forest) and exploring the whole set of possible feature selections.ResultsThe study population consisted of 20 complete responders and 40 non-complete responders. Models including MRI radiomic features consistently showed better performance compared to combinations of other clinical, histological and radiological information. The AUC (ROC analysis) of predictors that did not include radiomic features reached up to 0.89, while all three classifiers gave AUC higher than 0.90 with the inclusion of radiomic information (range: 0.91-0.98).ConclusionsRadiomic features extracted from 3T DCE-MRI consistently improved predictive models of complete response to neo-adjuvant chemotherapy. However, further investigation is necessary before this information can be used for clinical decision making.