bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relational dimensions, motivation and knowledge-sharing in healthcare: a perspective from relational models theory
Authors: Monazam Tabrizi Negar 
Published: August 2021

This study investigates the relational dimensions that shape clinicians' intentionality and motivation for knowledge-sharing. Qualitative data was collected from 40 clinicians in two hospitals, and relational models theory was used to investigate the impact of different relational models (communal-sharing, authority-ranking, equality-matching and market-pricing) on clinicians' intentionality and motivation to engage in knowledge and learning. While communal-sharing and expert-based authority–ranking relationships predominantly encourage intra-professional knowledge-sharing, equality-matching encourages inter-professional knowledge-sharing. This implies that while the idea is to work together to improve public service quality, each actor has their own interests and is motivated to share knowledge for different collective and/or personal reasons/agendas. In the public sector, formal authority-ranking and market-pricing are the main driving forces of coordination of actions and knowledge flow, through the medium of money and trade. Despite this, power games and a lack of support from those in positions of authority and ignorance of potential conflicts of interest, as well as extrinsic motivators, hamper knowledge-sharing, all of which threaten patient safety. Points for practitioners In pursuit of public service improvement, a focus on fostering an organizational culture that promotes collective behaviour, especially among those in authority, is crucial, given that their lack of support retards knowledge-sharing. For effective knowledge-sharing, both intrinsic and extrinsic motivators are equally important depending on the relational model.
Retrospective Investigation of Contralateral Hearing Thresholds of Patients With Sporadic Vestibular Schwannoma
Authors: Peter Nicole , Huber Alexander , Egli Simon , Held Ulrike , Steigmiller Klaus , Röösli Christof 
Published: August 2021

ObjectiveThe aim of this study was to investigate the contralateral hearing of patients with sporadic vestibular schwannoma (VS).Study DesignRetrospective cohort study.SettingPure‐tone audiograms of the contralateral ear from patients with a wait‐and‐scan strategy were compared to the ones who received therapy. Due to a possible bias caused by the therapy, hearing thresholds before and after radiotherapy or surgery were compared separately with the wait‐and‐scan group.MethodsFrom 1979 to 2017, 508 patients with sporadic VS could be included in the study. Of these, 240 received regular controls in the sense of wait‐and‐scan, 72 underwent radiotherapy (63 audiograms before and 43 after radiotherapy), and 196 had a surgery (186 audiograms before and 146 after surgery). Age‐normalized hearing thresholds of the contralateral ear from patients with a wait‐and‐scan strategy were compared to ones who received therapy. In addition, hearing thresholds were compared to norm values.ResultsThere was no evidence for a difference in the contralateral hearing of patients with sporadic VS between the wait‐and‐scan and therapy groups. The mean difference of hearing thresholds in our sample to norm values was found to be larger for the high frequencies and more pronounced in male patients.ConclusionThere was no evidence for a difference in the contralateral hearing loss of patients with sporadic VS between the wait‐and‐scan and therapy groups. However, there was some indirect indication of poorer contralateral hearing in all patients with sporadic VS compared to normative values.
The changing status of European Union nationals in the United Kingdom following Brexit: The lived experience of the European Union Settlement Scheme
Authors: Barnard Catherine , Fraser Butlin Sarah , Costello Fiona 
Published: August 2021

Following Brexit, European Union citizens now find their rights to live and work in the UK have changed and they had to make an application under the European Union Settlement Scheme, established under the terms of the Withdrawal Agreement, by 30 June 2021 to enable them to continue to live in the UK lawfully. This article examines the experience and perceptions of those navigating the European Union Settlement Scheme and how they feel about life in the UK post-Brexit. It raises questions about identity and belonging. We also examine the other routes European Union nationals, and their family members, are choosing to use to secure their status in the UK. Our research highlights how the impacts of Brexit and European Union Settlement Scheme are unevenly felt and experienced by different European Union national groups. The article concludes that it is likely that we will only be able to measure the true extent of the ‘success’ of the European Union Settlement Scheme after the application gateway has closed on 30 June 2021, by learning what happens to those who fall between the gap, especially those more vulnerable.
Brexucabtagene Autoleucel: A Novel Chimeric Antigen Receptor T-cell Therapy for the Treatment of Mantle Cell Lymphoma
Authors: Anderson Mary Kate , Torosyan Annie , Halford Zachery 
Published: August 2021

Objective: To identify and assess the current literature surrounding the safety, efficacy, and practical considerations of brexucabtagene autoleucel (brexu-cel) for the treatment of relapsed or refractory (r/r) mantle cell lymphoma (MCL). Data Sources: An English-based literature search was conducted using the terms “ brexucabtagene autoleucel” AND “ mantle cell lymphoma” OR “ KTE-X19”in PubMed (inception through May 1, 2021), EMBASE (inception through May 1, 2021), and ClinicalTrials.gov. Study Selection and Data Extraction: All studies evaluating the use of brexu-cel in MCL were considered for inclusion. Data Synthesis: In the pivotal ZUMA-2 trial, brexu-cel demonstrated objective response and complete response rates of 85% and 59%, respectively. These results were consistent among high-risk subgroups. Noteworthy treatment-related adverse effects included grade ≥3 cytopenias (94%), immune effector cell–associated neurotoxicity syndrome (31%), and cytokine release syndrome (15%). Brexu-cel elicited a toxicity profile similar to that of other novel chimeric antigen receptor (CAR) T-cell products, with no new safety signals. Relevance to Patient Care and Clinical Practice: There are currently no head-to-head clinical trials evaluating brexu-cel against other approved subsequent-line options in r/r MCL. In a relatively small phase II trial, brexu-cel demonstrated impressive response rates in heavily pretreated patients, with few viable alternatives. Long-term safety and efficacy outcomes with brexu-cel are unknown. The prevention, identification, and management of unique CAR T-cell toxicities requires expert care from a well-trained interdisciplinary team. Conclusion: Brexu-cel has emerged as a viable treatment option in MCL. Additional studies are required to determine the optimal sequencing and place in therapy for brexu-cel in this highly heterogeneous, pathobiologically distinct, and incurable malignancy.
Identifying the Assumptions and Bias That Affect Screening and Brief Interventions for Harmful Alcohol Use
Authors: Johnston Brenda 
Published: August 2021

Background: Screening for harmful alcohol use (HAU) is standard in clinical settings; however, self-reports of the quantity/frequency of use are often inconsistent with population survey data and objective assessment. Inaccuracies of self-reported alcohol use prompt exploration of patients’ reluctance to share this information with their health care providers. Objectives: The purpose of this article is to identify the assumptions and biases that affect screening and brief interventions for HAU. Method: A total of 22 research articles were selected for a systematic review of the literature. The studies included prospective and retrospective studies, randomized controlled trials, case studies, and quantitative and qualitative research from 2015 to 2021. Results: This systematic review identified alcohol health literacy, the inherent bias of surveys and screening tools, stigma, avoidance bias, and the normalization/villainization of alcohol use as contributors to the assumptions and biases that affect screening and brief interventions for HAU. Conclusions: Exploring these assumptions and biases presents opportunities to develop strategies that promote positive change.
Dynamics of Youth and Gender Divide in Technology in Bangladesh
Authors: Raihan Selim , Uddin Mahtab , Ahmmed Sakil 
Published: August 2021

This article identifies the nature of gendered digital divides between male and female youth (aged 15–29) in the context of Bangladesh. As a measuring indicator for technology inclusiveness, this study examines whether a young male or female owns a mobile phone, the most basic means of accessing the Internet. As observed in the descriptive analysis, on average, 46% of young females have a mobile phone, compared to 79% young males. However, such disparity varies across age cohorts and the divides of rural–urban, poor–non-poor, richer–poorer income deciles, etc. To understand whether there is any significant discrimination against women in terms of technology inclusiveness, this study applies the Blinder–Oaxaca (B–O) decomposition technique. The decomposition analysis shows statistically significant discrimination against women in terms of mobile ownership at both the household and the individual level. The factors such as remittances, average years of schooling of the household members, urban residence, household’s income status, etc., significantly reduce discriminatory behaviour towards young females. JEL: D63, O33, I21
Informal caregiver experiences at the end-of-life of individuals living with dementia with Lewy bodies: An interview study
Authors: Armstrong Melissa J , Alliance Slande , Corsentino Pamela , Lunde Angela , Taylor Angela 
Published: August 2021

Individuals with dementia with Lewy bodies (DLB) commonly die from dementia-related causes, but little is known regarding caregiver experiences during the end-of-life period in DLB. This reflects a critical knowledge gap given the high frequency of informal caregiving for individuals with dementia, high caregiver burden in DLB, and the fact that most individuals with DLB die from this disease. Investigators conducted telephone interviews with family members of individuals who died with DLB in the last 5 years. Investigators used a qualitative descriptive approach to analyze interview transcripts. Participants included 15 children, 13 spouses, and 2 other family members. Interviews averaged 31 min. Major themes included caregivers as the main drivers of care for individuals with DLB throughout the disease course and at the end of life, the impact of DLB features (e.g., fluctuations, hallucinations, and delusions) on end-of-life experiences, experiences relating to the caregiving role, death and post-death experiences, and supports employed by caregivers in the end-of-life period. End-of-life experiences for caregivers of individuals with DLB built on the accumulated burden of the disease course, where caregivers were often responsible for driving DLB care—from making the diagnosis to educating healthcare professionals and double-checking medical decisions. While some end-of-life experiences were consistent with those described in dementia palliative care more generally (e.g., financial stresses, poor sleep, being overwhelmed, and needing increased education and support), many DLB features specifically affected end-of-life caregiver experiences, such as the presence of delusions. Improving caregiver experiences at the end of life in DLB will require improved diagnosis and care for individuals with DLB throughout the disease course and also better strategies for treating behavioral symptoms. More research is needed regarding drivers of quality end-of-life experiences for individuals with DLB and their families and how drivers and strategies may differ between dementias.
A Mock Circulation Loop for In Vitro Hemodynamic Evaluation of Aorta: Application in Aortic Dissection
Authors: Chen Duanduan , Liang Shichao , Li Zhenfeng , Mei Yuqian , Dong Huiwu , Ma Yihao , Zhao Jing , Xu Shangdong , Zheng Jun , Xiong Jiang 
Published: August 2021

Purpose Aortic dissection (AD) is a catastrophic disease with complex hemodynamic conditions, however, understandings regarding its perfusion characteristics were not sufficient. In this study, a mock circulation loop (MCL) that integrated the Windkessel element and patient-specific silicone aortic phantoms was proposed to reproduce the aortic flow environment in vitro. Materials and Methods Patient-specific normal and dissected aortic phantoms with 12 branching vessels were established and embedded into this MCL. Velocities for aortic branches based on 20 healthy volunteers were regarded as the standardized data for flow division. By altering boundary conditions, the proposed MCL could mimic normal resting and left-sided heart failure (LHF) conditions. Flow rates and pressure status of the aortic branches could be quantified by separate sensors. Results In normal resting condition, the simulated heart rate and systemic flow rate were 60 bpm and 4.85 L/minute, respectively. For the LHF condition, the systolic and diastolic blood pressures were 75.94±0.77 mmHg and 57.65±0.35 mmHg, respectively. By tuning the vascular compliance and peripheral resistance, the flow distribution ratio (FDR) of each aortic branch was validated by the standardized data in the normal aortic phantom (mean difference 2.4%±1.70%). By comparing between the normal and dissected aortic models under resting condition, our results indicated that the AD model presented higher systolic (117.82±0.60 vs 108.75±2.26 mmHg) and diastolic (72.38±0.58 vs 70.46±2.33 mmHg) pressures, the time-average velocity in the true lumen (TL; 36.95 cm/s) was higher than that in the false lumen (FL; 22.95 cm/s), and the blood transport direction between the TL and FL varied in different re-entries. Conclusions The proposed MCL could be applied as a research tool for in vitro hemodynamic analysis of the aorta diseases under various physical conditions.
Research on Individuals Aged One Hundred and Over: Protocol from the Sevilla and Castilla y León Centenarian Studies
Authors: García-González Juan Manuel , del Rey Alberto 
Published: August 2021

Spain’s population of people aged 100 years and over has increased tenfold since the last quarter of the 20th century, exceeding 16,000 individuals by 2019. Despite this cohort’s growth, which has made centenarians a significant segment of Spain’s population in their own right, centenarians have remained little studied from the perspective of social sciences. A key challenge for research concerning centenarians is understanding their personal experiences of reaching this landmark age; such information could help to identify the sociodemographic and psychosocial factors that enable people to live such extraordinarily long lives. Given this context, the present article describes the research protocol followed in the projects SeviCent – Sevilla Centenarian Study and C&LCent – Castilla y León Centenarian Study, which are mainstream qualitative studies of people aged 100 years and over who reside in the regions with the lowest and highest life expectancy in Spain, respectively. The general aim of these studies was to analyze, through semi-structured interviews conducted between 2018 and 2019 that were based on a biographical and life-cycle approach, the physical, social, and emotional wellbeing of a cohort of centenarians who had no cognitive impairments. Specifically, based on the experiences of applying this protocol, the present study describes the methodological considerations—research design, sampling, interview script, indicators, fieldwork, and analysis plan—that should be included in future qualitative, social sciences–focused studies concerning very old people for whom the population segment is scarce, scattered, and fragile.
Complications Associated with PROPEL Mometasone Furoate Bioabsorbable Drug-eluting Sinus Stents From 2012 to 2020
Authors: Shah Viraj N. , Pasick Luke J. , Benito Daniel A. , Ghiam Michael K. , D’Aguillo Christine 
Published: August 2021

Background Till date, there have been no studies that have analyzed a database to examine postmarket adverse events associated with PROPEL mometasone furoate bioabsorbable drug-eluting sinus stents. Objective To determine the postmarket complications associated with PROPEL mometasone furoate bioabsorbable drug-eluting sinus stents. Methods The US Food and Drug Administration’s Manufacturer and User Facility Device Experience database was searched for adverse events associated with PROPEL bioabsorbable drug-eluting sinus stents between January 1, 2012 and December 31, 2020. Data were extracted and analyzed from medical device reports (MDRs) that involved sinus stents. Results After 47 MDRs were identified, 25 reports involving PROPEL bioabsorbable drug-eluting sinus stents were reviewed, from which 40 adverse events were recorded. Of these, there were 32 adverse events to patients and 8 device malfunctions. The most common adverse events to patients included infection (21.8%), oropharyngeal obstruction (15.6%), and headache/pain (12.5%). The most common device malfunction reported was migration and expulsion of the stent (87.5%). Conclusions PROPEL sinus stents have been shown to be effective in preventing sinus outflow obstruction after functional endoscopic sinus surgery. Both adverse events to patients and device malfunctions are reported infrequently. A more comprehensive understanding of rare postmarket complications seen with PROPEL sinus stents may further aid informed decision-making regarding their usage.
Patient Satisfaction With Oral vs Intravenous Sedation for Vitrectomy Surgery: A Randomized, Noninferiority Clinical Trial
Authors: Siegel Nicole H. , Fiorello Marissa G. , Ness Steven , Kim Jiwoo , Vig Viha , Peeler Crandall E. , Chen Xuejing , Subramanian Manju L. 
Published: August 2021

Purpose: This work aims to determine whether patient satisfaction with oral sedation is noninferior to intravenous (IV) sedation in vitrectomy surgery. Methods: This prospective, randomized, double-masked, noninferiority clinical trial measured patient satisfaction in 84 participants receiving oral or IV sedation during vitrectomy surgery under monitored anesthesia care. Patients were excluded if they were unable to receive benzodiazepines. Results: The primary outcome was patient satisfaction. Secondary outcomes included surgeon and anesthesia provider satisfaction, need for supplemental anesthesia, and surgical complications. Among the 84 patients (46 [54.8%] men; mean [SD] age, 57.0 [12.7 years]), mean patient satisfaction scores were 5.22 ± 0.81 (range, 3.08-6; scale 1-6) with oral and 5.25 ± 0.63 (range, 3.83-6; scale 1-6) with IV sedation. With an a priori noninferiority margin of 0.5 and a difference in mean scores between the groups of 0.03 (1-tailed 95% CI, infinity to 0.29), our results demonstrated the noninferiority of oral sedation ( P = .002). There were no significant differences in surgeon or anesthesia satisfaction or major intraoperative complications. Five patients receiving oral (11.9%) and 3 receiving IV (7.1%) sedation required supplemental IV sedation (difference, 4.8%; P = .46). Conclusions: Patient satisfaction for oral sedation was noninferior to IV sedation for vitrectomy surgery.
An interrater reliability study of gait analysis systems with the dual task paradigm in healthy young and older adults
Authors: Klotzbier Thomas Jürgen , Wollesen Bettina , Vogel Oliver , Rudisch Julian , Cordes Thomas , Jöllenbeck Thomas , Vogt Lutz 
Published: August 2021

Abstract
Background and aims
One reason for the controversial discussion of whether the dual task (DT) walking paradigm has an added value for diagnosis in clinical conditions might be the use of different gait measurement systems. Therefore, the purpose was 1) to detect DT effects of central gait parameters obtained from five different gait analysis devices in young and old adults, 2) to assess the consistency of the measurement systems, and 3) to determine if the absolut and proportional DT costs (DTC) are greater than the system-measurement error under ST.

Methods
Twelve old (72.2 ± 7.9y) and 14 young adults (28.3 ± 6.2y) walked a 14.7-m distance under ST and DT at a self-selected gait velocity. Interrater reliability, precision of the measurement and sensitivity to change were calculated under ST and DT.

Results
An age effect was observed in almost all gait parameters for the ST condition. For DT only differences for stride length (p < .029, ɳ2p = .239) as well as single and double limb support (p = .036, ɳ2p = .227; p = .034, ɳ2p = .218) remained. The measurement systems showed a lower absolute agreement compared to consistency across all systems.

Conclusions
When reporting DT effects, the real changes in performance and random measurement errors should always be accounted for. These findings have strong implications for interpreting DT effects.
Modified completely intrafascial radical cysprostatectomy for bladder cancer: a single-center, blinded, controlled study
Authors: Wang Xiao , Guo Jia , Wang Lei , Wang Min , Weng Xiaodong , Chen Hui , Liu Xiuheng 
Published: August 2021

Abstract
Background
We have proposed a modified, completely intrafascial radical cysprostatectomy (RC) to treat bladder cancer patients with the aim of preserving the patients’ post-surgical urinary control and erectile function. This study aimed to evaluate the oncological and functional outcomes of this innovation relatively to that with the conventional technique.

Methods
A retrospective, single-center, blinded, and controlled study was conducted using the medical data of patients since the past 5 years from the hospital database. A total of 44 patients were included, including 20 who received complete intrafascial cysprostatectomy and 24 who received conventional interfascial surgeries. The patients’ continent and sexual information of 1-year follow-up after the surgery were extracted. The oncological and functional outcomes of the 2 groups were compared and analyzed.

Results
The demographics parameters of the 2 groups showed no significant difference. The results of follow-up of the oncological outcomes did not reveal any significant difference between the completely intrafascial group and the conventional interfascial group in terms of the positive surgical margins, local recurrences, and distant metastasis. Patients following neobladder diversion in the intrafascial group showed a faster recovery of the urinary control, with a 76.9% (10/13) daytime continent rate at 3-month, as well as 46.2% (6/13) and 58.3% (7/12) nighttime continent rates at 3-month and 6-month, respectively. Regarding the sexual functions, our results revealed significant advantages in favor of completely intrafascial technique on the post-surgical International Index of Erectile Function (IIEF)-5 score at 3-, 9-, and 12-month follow-up relative to that with the conventional interfascial process. Thus, the IIEF score of patients in the intrafascial group was 11.4 ± 3.5 at 3-month, 14.1 ± 3.6 at 9-month, and 15.2 ± 3.8 at 12-month follow-up after the cystectomy, which was significantly greater than that of the patients in the control group.

Conclusions
Our novel data illustrated that the modified completely intrafascial technique could result in a better sexual function and faster continence recovery for patients following RC, without any compromise in the cancer control. Thus, this technique could be considered as an alternative extirpative technique for bladder cancer treatment in a clinical setting.