bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of novel cleaning systems on mock-ups of unvarnished oil paint and chalk-glue ground within the Munch Aula Paintings Project
Authors: Stoveland Lena Porsmo , Frøysaker Tine , Stols-Witlox Maartje , Grøntoft Terje , Steindal Calin Constantin , Madden Odile , Ormsby Bronwyn 
Published: November 2021

Abstract
Low-risk removal of embedded surface soiling on delicate heritage objects can require novel alternatives to traditional cleaning systems. Edvard Munch’s monumental Aula paintings (1911–16) have a long history of exposure to atmospheric pollution and cleaning campaigns that have compromised the appearance and the condition of these important artworks. Soiling removal from porous and water-sensitive, unvarnished oil paintings continues to be a major conservation challenge. This paper presents the approach and results of research into the effect and efficiency of three novel systems used for soiling removal: soft particle blasting, CO2-snow blasting, and Nanorestore Gel® Dry and Peggy series hydrogels. Cleaning tests were performed on accelerated-aged and artificially soiled mock-ups consisting of unvarnished oil paint and chalk-glue grounds. Visual and analytical assessment (magnification using a light microscope and scanning electron microscope, as well as colour- and gloss measurement) was carried out before and after mock-up cleaning tests and the results were compared to those obtained using the dry polyurethane sponges employed in the most recent Aula surface cleaning campaign (2009–11). Although the results varied, the Nanorestore Gel® series proved promising with respect to improved soiling removal efficiency, and reduced pigment loss for the water-sensitive surfaces evaluated, compared to dry sponges.
Potential utilization of satellite remote sensing for field-based agricultural studies
Authors: Jindo Keiji , Kozan Osamu , Iseki Kohtaro , Maestrini Bernardo , van Evert Frits K. , Wubengeda Yilma , Arai Egidio , Shimabukuro Yosio Edemir , Sawada Yoshito , Kempenaar Corné 
Published: November 2021

AbstractUsing satellite remote-sensing is a useful approach for agriculture to monitor plant and soil conditions and provide decision-making support to farmers. Recently, several types of tools and indices by the satellite remote-sensing have been developed for monitoring drought stress, changes in land uses, and crop–soil water relations. Although these techniques are powerful tools, especially in developing countries and regions where precise data of crop evaluation and yield statistics are not accessible, it is quite difficult for beginners to select the most suitable tool or index for their objectives. Major difficulties are in the specificity of the terminology, differences among the sensors (e.g., active vs. passive sensors), interpretation of imaginary data, and multidisciplinary topics. This work offers non-expert readers basic knowledge of remote-sensing use in agriculture, presenting advancements in the field and future insights. We review different sensors that are frequently used, such as optical sensors and synthetic aperture radar, as well as the following different purposes for using remote-sensing in agriculture: drought stress detection, monitoring land use in tropical regions (e.g., deforestation), and estimating water balance evapotranspiration in emerging and developing countries. Additionally, the integrated approach of remote-sensing data into the crop simulation model, which can provide a more holistic view of the plant and field status over cropping season, is described for the field-based studies.
Graphic abstract
Effect of interface-active proteins on the salt crystal size in waterborne hybrid materials
Authors: Stamboroski Stephani , Boateng Kwasi , Leite Cavalcanti Welchy , Noeske Michael , Beber Vinicius Carrillo , Thiel Karsten , Grunwald Ingo , Schiffels Peter , Dieckhoff Stefan , Brüggemann Dorothea 
Published: November 2021

AbstractAqueous processes yielding hybrid or composite materials are widespread in natural environments and their control is fundamental for a multiplicity of living organisms. Their design and in vitro engineering require knowledge about the spatiotemporal evolution of the interactions between the involved liquid and solid phases and, especially, the interphases governing the development of adhesion during solidification. The present study illustrates the effects of distinct proteins on the precipitation of sodium chloride encompassing the size, shape and distribution of halite crystals formed during the drying of droplets containing equally concentrated saline protein solutions. The precipitates obtained from aqueous sodium chloride formulations buffered with tris(hydroxymethyl)aminomethane (Tris) contained either bovine serum albumin (BSA), fibrinogen or collagen and were characterized with respect to their structure and composition using optical and electron microscopy as well as x-ray analysis. The acquired findings highlight that depending on the protein type present during droplet drying the halite deposits predominantly exhibit cubic or polycrystalline dendritic structures. Based on the phenomenological findings, it is suggested that the formation of the interphase between the growing salt phase and the highly viscous saline aqueous jelly phase containing protein governs not only the material transport in the liquid but also the material exchange between the solid and liquid phases.
Hypoglycemia possibly caused by CYP2C9-mediated drug interaction in combination with bucolome: a case report
Authors: Tateishi Hiroki , Miyazu Daisuke , Kurinami Miho , Ieiri Ichiro , Hirakawa Masaaki , Watanabe Hiroyuki 
Published: November 2021

Abstract
Background
Bucolome is a non-steroidal anti-inflammatory drug and uricosuric agent, currently used only in Japan. It is known to induce drug interactions by inhibiting cytochrome P450 (CYP) 2C9. It is often used to enhance the anticoagulant effect of warfarin by utilizing its drug interactions. There are only a few reports on drug interactions of bucolome and the mechanism remain poorly understood.

Case presentation
An 81-year-old woman with a history of type 2 diabetes mellitus was taking glimepiride 2 mg/day and voglibose 0.6 mg/day. After hospitalization, the patient underwent surgical aortic valve replacement surgery (day 0). Glimepiride and voglibose were resumed on the second postoperative day (day 2), and warfarin was started to prevent thromboembolism. Since the prothrombin time-international normalized ratio on day 9 was low at 1.24, 300 mg/day of bucolome was added to enhance the effect of warfarin. A gradual decrease in blood glucose levels was observed from the day after bucolome administration was initiated. Hypoglycemia in the 56–57 mg/dL range occurred before lunch and dinner on the 6th day (day 14) of bucolome administration, due to which voglibose was discontinued. Hypoglycemia below 70 mg/dL was not observed thereafter, and the general condition of the patient was stable.

Conclusions
Based on the clinical course and literature review, we believe that hypoglycemia in the present case was due to a drug interaction, caused by inhibition of CYP2C9 by bucolome and competitive inhibition of CYP2C9 by warfarin, which affected the pharmacokinetics of glimepiride. The possibility of hypoglycemia due to drug interactions should be considered by physicians, when bucolome is included to enhance the effect of warfarin, in patients taking glimepiride.
Metabolic and inflammatory biomarkers in children with atopic dermatitis (AD): a case-control study
Authors: Mohamed Amal Ahmed , Salah Eman Mohamed , Bedair Nermeen Ibrahim , Bassiouny Dina M. , Daifalla Aliaa E. M. , Behairy Ola G. , Fawazy Naglaa , Al Soda Mohamed F. , Farag Youssef M. K. 
Published: November 2021

AbstractBackgroundAtopic dermatitis is characterized by impaired skin barrier and altered cutaneous innate immunity. The estimated prevalence among Egyptian children was 10–12%. Several studies suggest that it may be associated with systemic comorbidities other than the spectrum of atopy, such as metabolic syndrome and other inflammatory conditions. The aim of this study is to compare the profile of systemic conditions of diabetes, dyslipidemia, and multiple inflammatory markers in children with and without diagnosed atopic dermatitis.MethodsOne hundred atopic dermatitis patients and 101 normal controls were collected from outpatient clinic based on their clinical condition, both had measurement of body mass index, blood sugar, serum insulin, lipid profile, C reactive protein, and gamma-glutamyl transferase.ResultsChildren diagnosed with atopic dermatitis had significantly higher levels of body mass index (34.7 ± 5.7 vs 26.1 ± 4.9), fasting glucose (143.2 ± 30.3 vs 100.8 ± 16.0), serum insulin (11.3 ± 4.4 vs. 4.6 ± 3.0), serum triglycerides (194.1 ± 38.1 vs 156.2 ± 31.6), total cholesterol (198.4 ± 27.7 vs 163.7 ± 27.7), alkaline phosphatase (229.4 ± 89.8 vs. 189.4 ± 46.8), and gamma-glutamyl transferase (54.7 ± 19.9 vs 34.3 ± 9.5), C-reactive protein level was approximately four times higher (19.9 ± 13.2 vs 5.1 ± 3.4) and the immunoglobulin E level was approximately 10 times higher (2050.3 ± 843.8 vs 252.7 ± 103.1) than in controlsConclusionWe found a positive relationship of atopic dermatitis with both diabetes and hyperlipidemia among children, and positive dose-response relationship of several non-traditional biomarkers of C-reactive protein, gamma-glutamyl transferase, and alkaline phosphatase with the presence and severity of atopic dermatitis.
Low-frequency Coding Variants Associated With Body Mass Index Affect the Success of Bariatric Surgery
Authors: Antoine Darlène , Guéant-Rodriguez Rosa-Maria , Chèvre Jean-Claude , Hergalant Sébastien , Sharma Tanmay , Li Zhen , Rouyer Pierre , Chery Céline , Halvick Sarah , Bui Catherine , Oussalah Abderrahim , Ziegler Olivier , Quilliot Didier , Brunaud Laurent , Guéant Jean-Louis , Meyre David 
Published: October 2021

Abstract

Context
A recent study identified 14 low-frequency coding variants associated with body mass index (BMI) in 718 734 individuals predominantly of European ancestry.

Objective
We investigated the association of 2 genetic scores (GS) with i) the risk of severe/morbid obesity, ii) BMI variation before weight-loss intervention, iii) BMI change in response to an 18-month lifestyle/behavioral intervention program, and iv) BMI change up to 24 months after bariatric surgery.

Methods
The 14 low-frequency coding variants were genotyped or sequenced in 342 French adults with severe/morbid obesity and 574 French adult controls from the general population. We built risk and protective GS based on 6 BMI-increasing and 5 BMI-decreasing low-frequency coding variants that were polymorphic in our study.

Results
While the risk GS was not associated with severe/morbid obesity status, BMI-decreasing low-frequency coding variants were significantly less frequent in patients with severe/morbid obesity than in French adults from the general population. Neither the risk nor the protective GS was associated with BMI before intervention in patients with severe/morbid obesity, nor did they affect BMI change in response to a lifestyle/behavioral modification program. The protective GS was associated with a greater BMI decrease following bariatric surgery. The risk and protective GS were associated with a higher and lower risk of BMI regain after bariatric surgery.

Conclusion
Our data indicate that in populations of European descent, low-frequency coding variants associated with BMI in the general population also affect the outcomes of bariatric surgery in patients with severe/morbid obesity.
Patients With Cirrhosis Have Elevated Bone Turnover but Normal Hepatic Production of Osteoprotegerin
Authors: Jørgensen Niklas Rye , Diemar Sarah Seberg , Christensen Gitte Lund , Kimer Nina , Danielsen Karen Vagner , Møller Søren 
Published: October 2021

Abstract

Context
Severe osteodystrophy is common in patients with liver dysfunction. Markers of bone metabolism may help in early diagnosis of osteodystrophy and in understanding underlying pathophysiological mechanisms.

Objective
To elucidate changes in bone metabolism associated with cirrhosis and to determine the route of elimination for the markers.

Methods
Case–control study at a public university hospital. Fifty-nine patients with cirrhosis (47 alcoholic and 12 nonalcoholic cirrhosis) and 20 controls were included. Participants underwent catheterization of the femoral artery, and the hepatic, renal, and femoral veins with collection of blood from all 4 sites. Regional arteriovenous differences in concentrations of bone metabolism markers were determined: procollagen of type I collagen propeptide (PINP), C-terminal cross-linking telopeptide of type I collagen (CTX), osteocalcin, tartrate-resistant acid phosphatase isoform 5b (TRAcP5b), osteoprotegerin (OPG), and sclerostin and correlated with degree of disease (Child–Pugh classification).

Results
PINP concentration was higher (median: 87.9 µg/L) in patients with cirrhosis than in controls (52.6 µg/L) (P = .001), while hepatic extraction was lower (4.3% vs 14.5%) (P &lt; .001). Both CTX and TRAcP5b were higher in patients with cirrhosis (340 ng/L and 3.20 U/L) than in controls (215 ng/L and 1.60 U/L) (P &lt; .001 and P &lt; .0001). Hepatic sclerostin extraction was lower in patients with cirrhosis (14.6%) than in controls (28.7%) (P &lt; .0001). In both groups OPG showed a hepatic release rate (production) of 6%.

Conclusion
Patients with cirrhosis have increased bone resorption, but unaltered bone formation. Sclerostin is eliminated through the liver while OPG is produced in the liver. Bone markers may prove useful in evaluating bone turnover in patients with cirrhosis.
No Evidence of Long-Term Disruption of Glycometabolic Control After SARS-CoV-2 Infection
Authors: Laurenzi Andrea , Caretto Amelia , Molinari Chiara , Mercalli Alessia , Melzi Raffaella , Nano Rita , Tresoldi Cristina , Rovere Querini Patrizia , Ciceri Fabio , Lampasona Vito , Bosi Emanuele , Scavini Marina , Piemonti Lorenzo 
Published: October 2021

Abstract

Purpose
To assess whether dysglycemia diagnosed during severe acute respiratory syndrome coronavirus 2 pneumonia may become a potential public health problem after resolution of the infection. In an adult cohort with suspected coronavirus disease 2019 (COVID-19) pneumonia, we integrated glucose data upon hospital admission with fasting blood glucose (FBG) in the year prior to COVID-19 and during postdischarge follow-up.

Methods
From February 25 to May 15, 2020, 660 adults with suspected COVID-19 pneumonia were admitted to the San Raffaele Hospital (Milan, Italy). Through structured interviews/ medical record reviews, we collected demographics, clinical features, and laboratory tests upon admission and additional data during hospitalization or after discharge and in the previous year. Upon admission, we classified participants according to American Diabetes Association criteria as having (1) preexisting diabetes, (2) newly diagnosed diabetes, (3) hyperglycemia not in the diabetes range, or (4) normoglycemia. FBG prior to admission and during follow-up were classified as normal or impaired fasting glucose and fasting glucose in the diabetes range.

Results
In patients with confirmed COVID (n = 589), the proportion with preexisting or newly diagnosed diabetes, hyperglycemia not in the diabetes range and normoglycemia was 19.6%, 6.7%, 43.7%, and 30.0%, respectively. Patients with dysglycemia associated to COVID-19 had increased markers of inflammation and organs’ injury and poorer clinical outcome compared to those with normoglycemia. After the infection resolved, the prevalence of dysglycemia reverted to preadmission frequency.

Conclusions
COVID-19–associated dysglycemia is unlikely to become a lasting public health problem. Alarmist claims on the diabetes risk after COVID-19 pneumonia should be interpreted with caution.
Developmental Programming: Prenatal Testosterone Excess on Liver and Muscle Coding and Noncoding RNA in Female Sheep
Authors: Saadat Nadia , Puttabyatappa Muraly , Elangovan Venkateswaran R , Dou John , Ciarelli Joseph N , Thompson Robert C , Bakulski Kelly M , Padmanabhan Vasantha 
Published: October 2021

Abstract
Prenatal testosterone (T)-treated female sheep manifest peripheral insulin resistance, ectopic lipid accumulation, and insulin signaling disruption in liver and muscle. This study investigated transcriptional changes and transcriptome signature of prenatal T excess–induced hepatic and muscle-specific metabolic disruptions. Genome-wide coding and noncoding (nc) RNA expression in liver and muscle from 21-month-old prenatal T-treated (T propionate 100 mg intramuscular twice weekly from days 30-90 of gestation; term: 147 days) and control females were compared. Prenatal T (1) induced differential expression of messenger RNAs (mRNAs) in liver (15 down, 17 up) and muscle (66 down, 176 up) (false discovery rate &lt; 0.05, absolute log2 fold change &gt; 0.5); (2) downregulated mitochondrial pathway genes in liver and muscle; (3) downregulated hepatic lipid catabolism and peroxisome proliferator-activated receptor (PPAR) signaling gene pathways; (4) modulated noncoding RNA (ncRNA) metabolic processes gene pathway in muscle; and (5) downregulated 5 uncharacterized long noncoding RNA (lncRNA) in the muscle but no ncRNA changes in the liver. Correlation analysis showed downregulation of lncRNAs LOC114112974 and LOC105607806 was associated with decreased TPK1, and LOC114113790 with increased ZNF470 expression. Orthogonal projections to latent structures discriminant analysis identified mRNAs HADHA and SLC25A45, and microRNAs MIR154A, MIR25, and MIR487B in the liver and ARIH1 and ITCH and miRNAs MIR369, MIR10A, and MIR10B in muscle as potential biomarkers of prenatal T excess. These findings suggest downregulation of mitochondria, lipid catabolism, and PPAR signaling genes in the liver and dysregulation of mitochondrial and ncRNA gene pathways in muscle are contributors of lipotoxic and insulin-resistant hepatic and muscle phenotype. Gestational T excess programming of metabolic dysfunctions involve tissue-specific ncRNA–modulated transcriptional changes.
Using Immunohistochemistry to Expand the Spectrum of Lynch Syndrome–Related Tumors
Authors: Farha Natalie , Savage Erica , Sleiman Joseph , Burke Carol A. 
Published: November 2021

ABSTRACT
The most common genetic and molecular process leading to sporadic colorectal cancer is chromosomal instability. By contrast, mismatch repair deficiency, which results in high levels of microsatellite instability or lack of mismatch repair (MMR) protein expression on immunohistochemistry (IHC), is the predominant cancer pathway in patients with Lynch syndrome (LS). Importantly, patients with LS may still develop sporadic tumors through chromosomal instability. Testing tumors with IHC staining helps expand the spectrum of LS-related tumors. In this series, we describe 4 cancers in patients with LS that are not typical of the syndrome. Lack of MMR protein expression on IHC staining confirmed that 2 cancers are related to LS, expanding the spectrum of LS-related tumors, and the presence of MMR protein expression on IHC in the other 2 cases confirmed that they were sporadic and not related to mismatch repair deficiency and, thus, not related to LS.
ACADEMIC CAREER INTERESTS IN ACCOUNTING AND DARK TRIAD: EVIDENCE OF THE BRAZILIAN STUDENTS
Authors: Frigo Souza Fabiana , França Lopes Iago , Costa Flaviano , Colauto Romualdo Douglas 
Published: October 2021

Objective: The study aimed at verifying the association between Dark Triad and the interest in activities related to academic career among postgraduate accounting students.
Method: The sample consisted of 124 students from postgraduate programs in the Accounting Sciences in Brazil. Data were collected through a survey and submitted to multivariate analysis.
Results: The results show that narcissism and psychopathy are related to activities inherent to the academic career, while Machiavellian traits do not exhibit the same association. The lack of correlation between Machiavellianism and academic career activities may be related to the desired academic career profile. Students with narcissistic traits are adept at academic career activities mainly related to research and teaching. Psychopathic traits were not adept at activities related to teaching and extension (service to the external community), which may be related to the lack of empathy, lack of concern related to compliance with rules and insensitivity.
Contributions: The study contributes to the gap in accounting research that discusses non-pathological personality traits and career interests, since previous research has demanded attention in view of the objective and subjective issues inherent to the career and, at times, marginalize the relevant activities career choice. In addition, such discussions are presented as an advisory material for HEIs in terms of outlining the performance and interest of future teachers regarding the activities inherent to the academic career.
THE EUROPEAN UNION DISTINCTIVENESS: A CONCEPT OF THE RULE OF LAW
Authors: Mahmutovic Adnan , Lita Helza Nova 
Published: October 2021

This paper discusses the distinctiveness of the European Union with focus on the Rule of Law and its importance for the EU integration process. Rule of Law is a notion that is very frequently used, but at the same time quite controversial as it is not so easy always to reach generally accepted meaning. Therefore, this paper provides a analysis of the EU Rule of Law as multidimensional legal principle gravitating between values and principles. The paper acknowledges that a concept of the EU rule of law can be the subject of diverse interpretations and implementation. High-ranking government officials of a two EU member states, Poland and Hungary, have argued recently that a concept of the EU rule of law lacks well-defined rules and remains the subject of much debate. Therefore, the paper provides for better understanding of the concept itself within the specific supranational legal environment. Also, the paper argues that the future of the EU and its integrations depends largely on the respect of the rule of law that remains to be a core and the element of unity within Europe’s legal space. The relationship between the principles and values upon which the EU is founded remain close and interrelated. The EU Rule of law with all its distinctiveness can be concluded with certainty that it reflects a specific character and nature of the EU legal system.
Variation and change in idiolects: Tracing a lexical substitution inside a psychiatric hospital around 1900
Authors: Schiegg Markus 
Published: November 2021

Abstract
This paper presents a case study on the lexical substitution of Wärter (‘guard’) by Pfleger (‘nurse’) in records from a southern German psychiatric hospital around 1900. Its goal is to shed light on language variation and change from the perspective of idiolects. Therefore, I analyse how this change, implemented by official documents in 1876, spreads ‘from above’ into the written language of 108 patients and 10 family members. The results show a quick implementation of the new variant, comprising its semantic generalization and the near-complete replacement of the older variant. This process can sometimes be observed in individual lifespan changes, while other writers continue using Wärter in idiosyncratic ways. Finally, a comparison with two more general corpora (DWDS and Google Books) shows that this lexical change appears delayed and less consistent outside the hospital context.