bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alcohol consumption, depression, overweight and cortisol levels as determining factors for NR3C1 gene methylation
Authors: de Assis Pinheiro Júlia , Freitas Flávia Vitorino , Borçoi Aline Ribeiro , Mendes Suzanny Oliveira , Conti Catarine Lima , Arpini Juliana Krüger , dos Santos Vieira Tamires , de Souza Rafael Assis , dos Santos Dirceu Pereira , Barbosa Wagner Miranda , Archanjo Anderson Barros , de Oliveira Mayara Mota , dos Santos Joaquim Gasparini , Sorroche Bruna Pereira , Casali-da-Rocha José Claudio , Trivilin Leonardo Oliveira , Borloti Elizeu Batista , Louro Iuri Drumond , Arantes Lidia Maria Rebolho Batista , Alvares-da-Silva Adriana Madeira 
Published: March 2021

AbstractThe NR3C1 glucocorticoid receptor (GR) gene is a component of the stress response system, which can be regulated by epigenetic mechanisms. NR3C1 methylation has been associated with trauma and mental issues, including depression, post-traumatic stress, anxiety, and personality disorders. Previous studies have reported that stressful events are involved in NR3C1 gene methylation, suggesting that its regulation under environmental effects is complex. The present study aimed to analyze associations involving stressors such as socioeconomic status, health conditions, and lifestyle in relation to NR3C1 methylation in adults. This study included 386 individual users of the Brazilian Public Unified Health System (SUS), and evaluated socioeconomic and health conditions, body mass index, cortisol levels, and lifestyle. Data were correlated with NR3C1 methylation, determined using DNA pyrosequencing. The results showed that alcohol consumption, overweight, and high cortisol levels were related to NR3C1 demethylation, while depression was related to its methylation. Habits, lifestyle, and health status may influence NR3C1 gene regulation via methylation, revealing the complexity of environmental impacts on NR3C1 methylation.
Paraoxonase 1 concerning dyslipidaemia, cardiovascular diseases, and mortality in haemodialysis patients
Authors: Grzegorzewska Alicja E. , Adamska Paulina , Iwańczyk-Skalska Ewa , Ostromecka Kamila , Niepolski Leszek , Marcinkowski Wojciech , Mostowska Adrianna , Warchoł Wojciech , Żaba Czesław , Jagodziński Paweł P. 
Published: March 2021

AbstractParaoxonase 1 (PON1) is known for preventing atherosclerosis through lipid-modifying features, antioxidant activity, anti-inflammatory, anti-apoptosis, anti-thrombosis, and anti-adhesion properties. Uremic patients requiring haemodialysis (HD) are especially prone to atherosclerosis and its complications. We analysed the PON1 gene (PON1) polymorphisms and serum PON1 (paraoxonase) activity concerning dyslipidaemia and related cardiovascular diseases and mortality to show how they associate under uremic conditions modified by maintenance HD treatment. The rs662 AA + AG (OR 1.76, 95%CI 1.10–2.80, P = 0.018), rs854560 TT (OR 1.48, 95%CI 1.04–2.11, P = 0.031), and rs854560 AT + TT (OR 1.28, 95%CI 1.01–1.63, P = 0.040) contributed to the prevalence of atherogenic dyslipidaemia diagnosed by the triglyceride (TG)/HDL-cholesterol ratio ≥ 3.8. The normalized serum PON1 activity positively correlated with atherogenic dyslipidaemia (ẞ 0.67 ± 0.25, P = 0.008). The PON1 rs854560 allele T was involved in the higher prevalence of ischemic cerebral stroke (OR 1.38, 1.02–1.85, P = 0.034). The PON1 rs705379 TT genotype contributed to cardiovascular (HR 1.27, 95% CI 1.03–1.57, P = 0.025) and cardiac (HR 1.34, 95% CI 1.05–1.71, P = 0.018) mortality. All P-values were obtained in multiple regression analyses, including clinical variables. Multifaceted associations of PON1 with dyslipidaemia, ischemic cerebral stroke, and cardiovascular mortality in HD patients provide arguments for the consideration of PON1 and its protein product as therapeutic targets in the prevention of atherosclerosis and its complications in uremic patients.
Significant impact of circulating tumour DNA mutations on survival in metastatic breast cancer patients
Authors: Muendlein Axel , Geiger Kathrin , Gaenger Stella , Dechow Tobias , Nonnenbroich Christoph , Leiherer Andreas , Drexel Heinz , Gaumann Andreas , Jagla Wolfgang , Winder Thomas , Mayer Frank , Decker Thomas 
Published: March 2021

AbstractMutational analysis of circulating tumour (ct) DNA holds promise as an effective tool to predict the course of metastatic breast cancer (MBC). In the present study we used targeted next generation sequencing of ctDNA to evaluate the impact of cancer driven mutations on the prognosis of MBC. The study included 59 oestrogen receptor-positive (ER+), HER2-negative MBC patients. Sequencing analysis was performed in ESR1, PIK3CA, ERBB2, PTEN, TP53, KRAS, HRAS, NRAS, and AR. At baseline, patients started receiving either chemotherapy (34%; n = 20) or cyclin-dependent kinase 4/6 inhibitor therapy in combination with endocrine therapy (CDK4/6i+ET; 66%; n = 39). Overall, 64.4% (n = 38) of the patients carried at least one pathogenic or likely-pathogenic mutation. Number of ctDNA mutations was significantly linked with worse progression free survival (PFS; p = 0.003) and overall survival (OS; p = 0.007). Furthermore, ctDNA load, defined by the number of mutant ctDNA molecules per mL plasma, significantly correlated with PFS (p < 0.001) and OS (p = 0.001). Furthermore, mutational status of ESR1 and TP53 significantly predicted PFS (p = 0.024 and p = 0.035, respectively) and OS (p < 0.001 and p = 0.035, respectively). These results emphasizes the clinical value of ctDNA mutational analysis in the management of advanced breast cancer.
Comparative transcriptome and metabolome analysis of Ostrinia furnacalis female adults under UV-A exposure
Authors: Su Li , Yang Changli , Meng Jianyu , Zhou Lv , Zhang Changyu 
Published: March 2021

AbstractUltraviolet A (UV-A) radiation is a significant environmental factor that causes photoreceptor damage, apoptosis, and oxidative stress in insects. Ostrinia furnacalis is an important pest of corn. To understand the adaptation mechanisms of insect response to UV-A exposure, this study revealed differentially expressed genes (DEGs) and differently expressed metabolites (DEMs) in O. furnacalis under UV-A exposure. Three complementary DNA libraries were constructed from O. furnacalis adult females (CK, UV1h, and UV2h), and 50,106 expressed genes were obtained through Illumina sequencing. Of these, 157 and 637 DEGs were detected in UV1h and UV2h after UV-A exposure for 1 and 2 h, respectively, compared to CK, with 103 and 444 upregulated and 54 and 193 downregulated genes, respectively. Forty four DEGs were detected in UV2h compared to UV1h. Comparative transcriptome analysis between UV-treated and control groups revealed signal transduction, detoxification and stress response, immune defense, and antioxidative system involvement. Metabolomics analysis showed that 181 (UV1h vs. CK), 111 (UV2h vs. CK), and 34 (UV2h vs. UV1h) DEMs were obtained in positive ion mode, while 135 (UV1h vs. CK), 93 (UV2h vs. CK), and 36 (UV2h vs. UV1h) DEMs were obtained in negative ion mode. Moreover, UV-A exposure disturbed amino acid, sugar, and lipid metabolism. These findings provide insight for further studies on how insects protect themselves under UV-A stress.
Improving the performance of ghost imaging via measurement-driven framework
Authors: Kang Hanqiu , Wang Yijun , Zhang Ling , Huang Duan 
Published: March 2021

AbstractHigh-quality reconstruction under a low sampling rate is very important for ghost imaging. How to obtain perfect imaging results from the low sampling rate has become a research hotspot in ghost imaging. In this paper, inspired by matrix optimization in compressed sensing, an optimization scheme of speckle patterns via measurement-driven framework is introduced to improve the reconstruction quality of ghost imaging. According to this framework, the sampling matrix and sparse basis are optimized alternately using the sparse coefficient matrix obtained from the low-dimension pseudo-measurement process and the corresponding solution is obtained analytically, respectively. The optimized sampling matrix is then dealt with non-negative constraint and binary quantization. Compared to the developed optimization schemes of speckle patterns, simulation results show that the proposed scheme can achieve better reconstruction quality with the low sampling rate in terms of peak signal-to-noise ratio (PSNR) and mean structural similarity index (MSSIM). In particular, the lowest sampling rate we use to achieve a good performance is about 6.5%. At this sampling rate, the MSSIM and PSNR of the proposed scheme can reach 0.787 and 17.078 dB, respectively.
Reduced extrinsic recombination process in anatase and rutile TiO2 epitaxial thin films for efficient electron transport layers
Authors: Kim Yeon Soo , Jin Hye-Jin , Jung Hye Ri , Kim Jihyun , Nguyen Bich Phuong , Kim Juran , Jo William 
Published: March 2021

AbstractTiO2 is the most widely used material for the electron transport layers (ETLs) because it is characterized by proper band alignment with light absorbers, adequate optical transmittance, and high electron mobility. There are two thermodynamically stable crystal phases of TiO2: anatase and rutile. However, understanding which phase is more effective as the ETL is still required. In this paper, we demonstrate the different effects of using epitaxial anatase TiO2 and epitaxial rutile TiO2 (both grown using pulsed laser deposition) as the ETL material on the electrical and optical properties. Epitaxial Nb-doped TiO2 layers were used as the common electrode material for the both epitaxial ETLs for which the crystalline structural analysis revealed high crystalline qualities and good coherency for both phases. By analyzing the recombination kinetics, the anatase phase shows a preferable performance in comparison with the rutile phase, although both epitaxial phases show remarkably reduced extrinsic recombination properties, such as trap-assisted recombination. This study demonstrates not only a better electron transporting performance of anatase phase but also reduced extrinsic recombination through epitaxy growth.
Classification of thermal ageing impact of ester fluid‐impregnated pressboard material adopting LIBS
Authors: Amalanathan Arputhasamy J. , Vasa Nilesh J. , Harid Noureddine , Griffiths Huw , Sarathi Ramanujam 
Published: March 2021

AbstractThis article reports the thermal ageing of ester fluid‐impregnated pressboard material along with its performance evaluation using optical emission spectroscopy (OES) and classification using machine‐learning algorithms adopting laser‐induced breakdown spectroscopy (LIBS). The surface discharge analysis on ester‐impregnated pressboard (EIP) is studied using OES and the plasma temperature was evaluated based on the Cu I emission lines which were higher under the negative DC compared with the positive DC and AC voltages. The LIBS analysis was performed on the EIP material operated at different energy levels in order to acquire the optimal energy required to be used for its classification algorithm. The intensity ratio and electron density evaluated from LIBS studies correlated well with the plasma temperature. The lower limit of detection (LOD) calculated based on linear regression analysis for copper peak was around 3.5 times higher than the identification of carbon peak. The machine‐learning techniques like principal component analysis and neural network algorithm have been performed on the LIBS spectral dataset in order to classify the ageing of EIP material. Artificial neural network adopting LIBS provided a better classification accuracy on all the aged samples compared with principal component analysis which classified only for the samples aged at higher temperatures.
Nickel-Catalyzed Photodehalogenation of Aryl Bromides
Authors: Martin Ruben , Higginson Bradley , Sanjosé-Orduna Jesus , Gu Yiting 
Published: March 2021

AbstractHerein, we describe a Ni-catalyzed photodehalogenation of aryl bromides under visible-light irradiation that utilizes tetrahydrofuran as hydrogen source. The protocol obviates the need for exogeneous amine reductants or photocatalysts and is characterized by its simplicity and broad scope, including challenging substrate combinations
Double Aortic Arch with Coarctation of Aorta in an Adolescent: Unraveling the Vascular Ring
Authors: Rajbanshi Bijoy G. , Acharya Anil , Neupane Prabesh , Gautam Milan , Sharma Apurb , Kayastha Bhuwan , Ghimire Ram K. , Sharma Ranjit , Joshi Lava N. 
Published: March 2021

AbstractWe report the case of a 12-year-old girl with balanced double aortic arch with coarctation of the aorta presenting with symptoms of respiratory and swallowing difficulty. On investigation, the patient had a double aortic arch with coarctation and clinically nonsignificant disease in the infrarenal aorta. Division of the nondominant aortic arch was done through a left thoracotomy, along with resection of the coarctation segment and placement of an interposition Dacron tube graft.
A Case of Giant Aortoiliac Aneurysm Rupture when Open Repair Seems a One-Way Street
Authors: Galanopoulos Georgios , Papavassiliou Vassilios 
Published: March 2021

AbstractGiant aortoiliac aneurysm is a rare nosological entity. Owing to the increased diameter, the risk of rupture is extremely high and, similarly, the repair is extremely challenging. In this article, open surgical repair of a ruptured giant aortoiliac aneurysm in a 72-year-old male is described. A bifurcated Dacron graft was used with left internal iliac artery revascularization, while the contralateral internal iliac artery was ligated. The patient had an uneventful recovery.
Lung Ultrasound versus Chest X-Ray for the Detection of Fluid Overload in Critically Ill Children: A Systematic Review
Authors: Schapka Emily , Gee Jerica , Cyrus John W. , Goldstein Gregory , Greenfield Kara , Marinello Mark , Karam Oliver 
Published: March 2021

AbstractFluid overload is a common complication of critical illness, associated with increased morbidity and mortality. Pulmonary fluid status is difficult to evaluate clinically and many clinicians utilize chest X-ray (CXR) to identify fluid overload. Adult data have shown lung ultrasound (LUS) to be a more sensitive modality. Our objective was to determine the performance of LUS for detecting fluid overload, with comparison to CXR, in critically ill children. We conducted a systematic review using multiple electronic databases and included studies from inception to November 15, 2020. The sensitivity and specificity of each test were evaluated. Out of 1,209 studies screened, 4 met eligibility criteria. Overall, CXR is reported to have low sensitivity (44–58%) and moderate specificity (52–94%) to detect fluid overload, while LUS is reported to have high sensitivity (90–100%) and specificity (94–100%). Overall, the quality of evidence was moderate, and the gold standard was different in each study. Our systematic review suggests LUS is more sensitive and specific than CXR to identify pulmonary fluid overload in critically ill children. Considering the clinical burden of fluid overload and the relative ease of obtaining LUS, further evaluation of LUS to diagnose volume overload is warranted.
Gluteus and posterior thigh muscle sizes in sprinters: Their distributions along muscle length
Authors: Takahashi Katsuki , Kamibayashi Kiyotaka , Wakahara Taku 
Published: March 2021

ABSTRACTMuscle hypertrophy can occur non‐uniformly in athletes who repetitively perform particular movements, presumably leading to a unique muscle size distribution along the length. The present study aimed to examine if sprinters have unique size distributions within the gluteus and posterior thigh muscles. Nineteen male sprinters and 20 untrained males participated in the present study. T1‐weighted magnetic resonance images of the hips and right thigh were obtained in order to determine whole and regional (proximal, middle, and distal) volumes of the gluteus maximus and individual posterior thigh muscles. The results showed that the volumes of all the examined muscles relative to body mass were significantly larger in sprinters than in untrained males (all P < 0.001, d = 1.40–3.29). Moreover, the magnitude of the difference in relative volume between sprinters and untrained males was different between the regions within the gluteus maximus (P = 0.048, partial η 2 = 0.187), semitendinosus (P = 0.004, partial η 2 = 0.331), and adductor magnus (P = 0.007, partial η 2 = 0.322), but not within the other posterior thigh muscles (P = 0.091–0.555, partial η 2 = 0.025–0.176). The magnitude of the difference in relative volume between the sprinters and untrained males was greatest in the distal regions within the gluteus maximus and semitendinosus, while the proximal region within the adductor magnus. These findings indicate that sprinters have unique size distributions within the gluteus maximus, semitendinosus, and adductor magnus, which may be attributed to their competitive and training activities.
Highlights
Sprinters showed larger gluteus maximus and individual posterior thigh muscles than untrained males.
The magnitude of difference varied within the gluteus maximus, semitendinosus, and adductor magnus.
The greatest difference was found in distal regions within the gluteus maximus and semitendinosus, while proximal region within the adductor magnus.
Flexural behaviour of reinforced concrete beams with horizontal construction joints
Authors: Al-Rifaie Ali , Al-Hassani Hisham , Shubbar Ali A. 
Published: March 2021

Abstract
In the present research, ten simply supported reinforced concrete beams having a rectangular cross-section were cast and tested up to failure under the action of two-point loads. Eight of these beams were designed to contain horizontal construction joints (HCJs) of different number and location in the beam while the other two beams had no construction joint which were referred to as reference beams for the sake of comparison of results. All the tested beams had been designed to fail in flexure and had the same amount and type of longitudinal and transverse reinforcement as well as similar concrete properties. The results of this series of tests have indicated that the presence of HCJs in reinforced concrete beams leads to a decrease in its ultimate loads and increase in its ultimate deflection. The values of the recorded ultimate loads ranged between 83% to 98% times that of the reference beam while the ultimate deflection ranged between 102% to 133% times that of the reference beam.
Study of Electro-Fenton Oxidation for the Removal of oil content in refinery wastewater
Authors: Ahmed Idrees Hammoody , Hassan Ali A. , Sultan Hussein Kareem 
Published: March 2021

Abstract
In this study, refinery wastewater treatment scheme, the electro-Fenton oxidation process is obtainable. Through Fenton oxidation treatment, numerous working limits remained examined, for instance hydrogen peroxide, electrolysis time and pH. The effects of the working variables including the pH (2-9), hydrogen peroxide concentration (20-60 mg/L) and the reaction time (10-30 minutes) and remained thoughtful through means of answer surface methodology and Minitab-17. The current, agitation speed and sodium chloride of the aqueous solution consumed remained engaged as 1 Amps, 200 rpm and 0.2 g congruently. Beneath the finest standards of the employed variables extra than 98% oil removal in refinery wastewater.
Factors Influencing the Shear Strength of Clays: A review
Authors: Al-Adhadh Ahmed Raad , Abbas Basim Jabbar , Ali Atheer Muhammed 
Published: March 2021

Abstract
The shearing strength of clays is greatly affected by some factors. These factors are including the composition of soil minerals, the initial moisture content, the degree of saturation, the over-consolidation ratio, the initial void ratio, the porosity, the loading conditions (drained conditions versus undrained conditions), the pore fluid composition, weathering, the number of freeze-thaw cycles the soil is subjected as well as any stabilization techniques used on the clay mass. In this study, the effect of three factors (mineralogy, over-consolidation ratio, and drained versus undrained loading) are examined through the available technical literature. The conclusions made in the literature show that (a) the presence of montmorillonite in the soil mass can affect the shear strength in a more pronounced manner than other clay minerals, (b) the higher the over-consolidation ratio (OCR), the larger the shearing resistance of a soil mass, (c) soils loaded under drained conditions tend to exhibit higher strengths than those loaded under undrained conditions, (d) there are many methods to raise the un-drained shearing strength of the soil mass.
Evaluation of Using Photovoltaic Cell in the Electro-Fenton Oxidation for the Removal of Oil Content in Refinery Wastewater
Authors: Alturki Salwan Fadhil , Ghareeb Ahmed Hasan , Hadi Raid T. , Hassan Ali A. 
Published: March 2021

Abstract
In this study, the refinery wastewater treatment system by the photovoltaic electro-Fenton oxidation process was presented, which integrates the environmentally friendly photovoltaic and autonomous solar energy along with the capability of electro for oil content removing in the refinery wastewater. The direct connection between the photovoltaic panel and the electro-oxidation reactor can be accomplished without using batteries. This connection increases the sustainability of the system and eliminates the environment hazard resulted from the inappropriate disposal of the batteries. The photovoltaic electro-oxidation system is commonly made for multipurpose usage depending on the instantaneous solar irradiation by setting the volume of the wastewater to the supplied current intensity that provided by the photovoltaic array. The effect of several parameters that have critical impacts on the system efficiency of the presented process has studied by the Minitab-17 and the response surface methodology. Speed of agitation, solution electrolysis time, and the temperature have been presented and the optimal levels that corresponds to the optimal conditions were investigated and presented as well. Results of the experimental work showed that the working conditions of the agitation speed was 175 rpm, temperature was 70 oC and 15 min-reaction time, the concentration of oil in the treated refinery wastewater (RWW) was significantly decreased from 96.5 ppm (initial value) to specific values less than 2 ppm (the permissible limit), a removal percentage with an amount more that 98% and 20.4 kWh/m3 for the energy consumption were obtained. The suggested process is suitable for refinery wastewater remediation, especially for small amounts of oil content in RWW.