bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phytomorphology and Nutrient Dynamics of Mulberry Leaf
Authors: Angotra Jyoty , Bukhari Rubia , Shah Rashad Hussain , Sharma Kritika 
Published: January 2021

Background: The present study on the topic “Phytomorphology and nutrient dynamics of mulberry leaves” revealed high variability among mulberry varieties. Internodes were largest in variety Tr4 (6.06%). Actual leaf area was high in variety S146 (275.57 cm2). Numbers of leaves per meter branch was largest in variety S1531 (20.9). During 5 periodic sampling from sprouting to maturity average fresh and dry leaf weight of 100 leaves was high (197.93g) and (60.24g) respectively during 5th sampling. Average moisture content was high (83.41%) during 1st sampling highest average chlorophyll content (SPAD value) was also observed during 4th sampling (40.01%). Acidity was also high in variety Tr4 during maturity. Sugar content was high in variety T1 (3.66%) during 1st sampling (15 days). Starch and ash content was high in variety S1708 (43.06%) and (32.50%) during 5th sampling. Nitrogen and protein content was highest in variety S1608 (5.02%) and (31.56%) respectively during 1st sampling. Methods: In the field-laboratory investigation was conducted at Division of Sericulture, Division of Biochemistry and Plant Physiology, SKUAST-J, Chatha, during spring 2013. Ten mulberry varieties T1, Tr4, V1, S146, S1708, S799, S1608, S1531, S41 and Sujanpur were evaluated for phytomorphological and nutrient dynamic studies. The experiment was laid in complete randomized block design with three replicates. Each variety was taken as treatment and observations were recorded after 15 days interval upto 75th day after sprouting. Result: On the basis of current result, parameter observed fluctuations from the date of sprouting till maturity. Varietal response to periodic sampling too varied. Protein decreases age along with sugar, nitrogen. On the contrary starch, biomass, ash, chlorophyll shown a gradual increase. This information can be utilized to harvest a particular type of leaf for a particular age and rearing.
Lean manufacturing implantation impacts: a study on a large logistics operator
Authors: Jeunon Ester Eliane , Oliveira Júnior Francisco de , Duarte Leonora da Cunha , Guimarães Eloisa Helena Rodrigues 
Published: January 2021

Abstract Objective: This work aimed to analyze how the Lean methodology has caused changes in organizational processes in a logistics company.Methodology: A descriptive and qualitative research was carried out in one of the branches of a large logistics operator located in the city of Vinhedo (SP). Questionnaires were applied and interviews were conducted with logistics experts, organization leaders, Lean Manufacturing managers and operators, coming to a total of 100 respondents, including organizational change factors such as Kaizen application for process improvement, 5S's for organization and cleaning and Kanban for production control.Results: It was evident that factors such as productivity, quality, organization, among others were factors for the implantation of the methodology in the company.Corporative results: The results revealed that after the implementation of Lean management, there were changes such as a better understanding of the proposed methodology, reorganization of processes and gain in productivity and quality, thus raising the level of competitiveness of the organization. Keywords: Organizational change, Lean Manufacturing, Logistics.
Conditions d’élevage des palmipèdes à foie gras : des demandes sociétales à une démarche de progrès
Authors: LITT Joanna , LETERRIER Christine , FORTUN-LAMOTHE Laurence 
Published: January 2021

La pratique du gavage des palmipèdes consiste à introduire un tube (embuc) dans l’œsophage des animaux pour y déposer de l’aliment en quantité croissante afin de produire du foie gras. Cette pratique est remise en question et fortement contestée par des associations de protection animale et une partie de la société. En l’absence d’une alternative efficace, elle reste toutefois la seule façon de produire du foie gras à grande échelle, produit auquel reste attachée une majorité de français. Cette synthèse replace la production de foie gras au sein des questions sociétales autour du bien-être des animaux et fait le point sur les données scientifiques sur l’impact du gavage au sens large (introduction de l’embuc, charge alimentaire, mode d’hébergement) sur différents indicateurs de l’état de l’animal. Il apparaît ainsi notamment que i) le gavage et l’hypertrophie hépatique ne sont probablement pas nociceptifs en conditions normales de gavage ; ii) les animaux sont sensibles à la capture et à la contention ; iii) la fonction hépatique et la structure histologique sont préservées et l’hypertrophie hépatique est réversible ; iv) le gavage induit des modifications comportementales : augmentation de la fréquence d’abreuvement et de halètement sans apparition d’hypoxie ; diminution de la fréquence du toilettage ; v) ces comportements varient par ailleurs en fonction des conditions climatiques et de la configuration des logements ; vi) le gavage peut générer des blessures spécifiques (blessure de l’œsophage) lorsqu’il est mal réalisé et les conditions d’hébergement des animaux tendent à aggraver les lésions préexistantes (lésions des pattes) ; vii) la mortalité augmente pendant la période de gavage. Cet article synthétise aussi les connaissances et ressources disponibles pour mettre au point une méthode d’évaluation de l’état de l’animal, qui soit multicritère, adaptée aux palmipèdes pendant la phase de gavage et utilisable en ferme. Une telle évaluation permettrait d’objectiver l’état de confort ou d’inconfort des animaux et d’accompagner la filière de production de foie gras dans une démarche de progrès.
Incidence of intestinal parasitic infections among random samples at Al- Aziziyah hospital in Wasit province/Iraq
Authors: Jaffar Zeina Anwar , Shammari Ashwak jasim Kzar , Merdaw Maysoon Abdul-zahra 
Published: January 2021

The study is designed to identify intestinal parasitic infections examined at Al-Aziziyah Hospital in Wasit Governorate in Iraq. In this study, a total of (460) internal and external patients were monitored for intestinal parasitic infections. All stool samples were analyzed by the direct method (microscopic exam.) to discover the trophozoite stages and cyst stages for intestinal protozoan parasites. The most incidence parasites in different sex, area residence and different age groups. Out of (460) patient sample were infected with 217 at a percentage of (47.17%), 101(46.5%) were for males and 116 (53.5%) were for females. It was found that the numbers and percentages of a single (one type of parasite) and double (two type of parasite) infections were 207(95.4 %), 10 (4.6 %) respectively. Intestinal parasitic infections were found in (95.4 %) of the study population (17.9 % 1-5 age). E. histolytica was more common among the positive samples collected from intestinal parasitic species detected in this work. The prevalence of parasitic infection was significantly higher among younger age groups compared with older age groups. The age group 55 years had the highest incidence rate (17.9%) compared with other age groups (7.8%). The distribution of parasitic diseases between rural areas was 66.4% and urban areas was 33.6%.n conclusion, the incidence of intestinal parasitic infection among random sample demands improvement of health education with environmental sanitation and quality of water sources.
PARTICULARITIES OF THE COURSE AND TREATMENT HEMANGIOMAS OF DIFFERENT MORPHOLOGICAL TYPES IN CHILDREN AND THEIR ASSOCIATION WITH SOLUBLE FORMS OF FAS AND FASL
Authors: Vivcharuk Viktoriia 
Published: January 2021

The article discusses analysis of examinations and treatment results 100 children with hemangiomas different localizations on the different stages of existence. The study included patients of different ages, from birth to 6 years. Importance of primary assessment of severity and activity of hemangioma`s, for the choice of treatment, was considered. Correlation between clinical course of hemangiomas and soluble Fas/FasL was analyzed. The object of the research: Clinical course of hemangiomas of different morphological types, soluble form of Fas and FasL in the serum of patients with hemangiomas. Investigated problem: Improving the results of treatment of hemangiomas in children. The main scientific results: Predicting the course of hemangiomas in children allows to determine the need for treatment at different stages of their existence, as well as to carry out timely correction of the prescribed treatment to achieve good cosmetic and functional results. The area of practical use of the research results: Department of Pediatrics, Pediatric Surgery, Dermatology. Innovative technological product: Defined characteristics will help in predicting the course of hemangiomas and the effectiveness of their treatment. Scope of the innovative technological product: Clinical pediatric practice.
A Terra Subtil
Authors: Godinho Gil Ana 
Published: January 2021

Vivemos tempos estranhos e ameaçadores. Pandemia e alterações climáticas são suficientemente graves para nos deixar numa perplexidade sem nome. Como descrever o que se está a passar nos múltiplos planos em que se desdobram as nossas subjectividades? Que aconteceu aos nossos corpos e aos nossos afectos? À nossa potência de vida?
Pensamos numa hipótese - experimentar cruzar a mudança radical dos nossos hábitos e mentalidades com a transformação dos sistemas sociais, agindo todos juntos, acreditando noutra coisa – na Terra.
Effect of TRAF1 on Phenotypic Changes Of Kupffer Cells In Liver Transplantation Ischemic-Reperfusion
Authors: Zhang Zhen , Que KeTing , You Yu , Zhao XiaoPing , Wen DiGuang , Feng ZhiHao , Liu ZuoJin 
Published: January 2021

Objective:
The purpose of this study was to explore the effect of TRAF1 on phenotypic
changes of KCs in I/R in liver transplantation.

Methods:
SD rats were randomly divided into sham group and liver transplantation I/R group. KCs
were extracted from rat livers in each group. KCs were transfected by lentivirus of si-TRAF1 or
si-HOIP, and induced by Lipopolysaccharide (LPS). Flow cytometry was used to detect cell apoptosis.
Western blot and RT-PCR were used to detect the protein and mRNA expression levels.

Results:
Compared with the sham group, the expression levels of TRAF1, TNF-α and IL-1β were
significantly increased in the I/R group (P<0.05). In addition, compared with the control group, the
expression levels of NF-κB (P65 and p-P65) and M1 phenotype (TNF-α and IL-1β) were notably
increased in si-TRAF1 and si-HOIP group (all P<0.05). Furthermore, the levels of Linear Ubiquitin
Complex (LUBAC) were markedly increased in LPS-induced KCs in comparison with the control
group (P<0.05). Moreover, compared with the control group, the expression levels of P65, p-P65,
TNF-α and IL-1β were notably decreased in the si-TRAF1 and si-HOIP group (P<0.05). The expression
levels of P65, p-P65, TNF-α and IL-1β were significantly increased in si-TRAF1 and
si-HOIP group when compared to the control group (P<0.05).

Conclusion:
TRAF1 was an important negative regulator of liver transplantation I/R by inhibiting
the activation of NF-κB in KCs and preventing its M1 phenotype transformation.
Effects of Relationship Enrichment Training on Improving Marital Satisfaction of Infertile Couples: A Randomized Clinical Trial
Authors: Masoumi Seyedeh Zahra , Oshvandi Khodayar , Rostami-Moez Masoumeh , Shayan Arezoo , Kazemi Farideh 
Published: January 2021

Background:
Infertility can cause low marital satisfaction. Marital satisfaction has an
important effect on infertile couples’ health.

Objective:
This study aimed to assess the effect of relationship enrichment training on improving the marital satisfaction
of infertile couples.

Methods:
This randomized clinical trial was conducted on 50 infertile couples in the infertility center
of Fatemiyeh Hospital in Hamadan, Iran in 2018. Participants were matched for demographic
characteristics and randomly assigned to intervention and control groups (each group had 25 couples).
Informed consent was obtained from all participants. The Enrich Marital Satisfaction questionnaire
and demographic information were used to collect data before the study and two months
after the intervention. Two trained midwifery students taught only the intervention group about the
relationship enrichment topics in seven sessions (each session = 90 minutes). The data were analyzed
by SPSS Statistics version 21 using analysis of covariance, independent t-test, chi-square, and
Mann–Whitney. The significance level was set at p ≤ 0.05.

Results:
There was no significant difference in demographic and obstetric information between the
two groups (p >0.05). The mean of marital satisfaction in the intervention group significantly increased
among women and men from 151.00 ±28.61 to 154.88 ±22.62 and from 152.56 ±27.33 to
159.24 ±22.14, respectively, (p <0.001). Conversely, the mean of marital satisfaction decreased
among women and men from 158.13 ±13.86 to 146.25 ±19.53 and from 164.25 ±17.00 to 153.17
±27.50 in the control group (p=0.02).

Conclusion:
Relationship enrichment training can be effective in promoting the marital satisfaction
of infertile couples.
Post-Exercise Ketosis, Salivary Uric Acid and Interleukin-6 after a Simulated Wheelchair Basketball Match
Authors: Raguzzini Anna , Toti Elisabetta , Bernardi Marco , Castellucci Fabio , Cavedon Valentina , Fedullo Anna Lucia , Milanese Chiara , Sciarra Tommaso , Peluso Ilaria 
Published: January 2021

Background::
Interleukin (IL)-6, total antioxidant capacity (TAC) and uric acid (UA) increase after exercise in
able-bodied individuals. Wheelchair Basketball Athletes (WBA), having low muscle mass, could be at risk of post-exercise
ketosis.

Objective::
This study aimed to evaluate the post-exercise ketosis, IL-6 and antioxidant response, in WBA of the Italian
National team, after a simulated match.

Methods::
Dietary intakes, Starvation Symptoms Inventory (SSI), percentage of fat mass (FM%) and basal Respiratory
Exchange Ratio (RER) and Basal Energy Expenditure (BEE), were evaluated. Salivary TAC, UA and IL-6 were measured:
before (PreM), at the end (EM) and 20 minutes after (PostM) the match. Capillary glucose and β-hydroxybutyrate (βHB)
were monitored. Percentage of Heart Rate Reserve (%HRR) was measured to evaluate exercise intensity.

Results::
WBA had low carbohydrates (43.5% of daily energy intake (En)) and high fat (36.3% En) intakes. The increase in
UA at PostM correlated with En (0.810, p<0.01) and was inversely related to βHB at EM (-0.719, p<0.05). Furthermore, at
PostM growing IL-6 levels correlated with BEE (0.778, p<0.05) and inversely related to FM% (-0.762, p<0.5) were found,
which in turn was correlated to SSI (0.781, p<0.05). Also βHB PostM correlated with SSI (0.761, p<0.05) but was inversely
related to RER (-0.745, p<0.05) and En (-0.826, p<0.01).

Conclusions::
Our study suggests that some WBA should improve their dietary habit in order to prevent post-exercise
ketosis and ameliorate the endogenous antioxidant response after exercise.
A Comparative Study of Selected Drug Delivery Systems: Key Emphasis on Cocrystallization
Authors: Dutt Braham , Choudhary Manjusha , Budhwar Vikas 
Published: January 2021

:The low solubility of an active pharmaceutical ingredient particularly biopharmaceutics classification system (BCS) Class II drugs leads to a lower dissolution profile, which in result causes a reduction in the overall bioavailability of drugs. Numerous approaches like nanotechnology, solid dispersion technique, micronization techniques, etc were aimed by scientists in the past to resolve this issue, but still not enough to get the desired outcomes.:Key focus of this review is the study of the advantages and disadvantages of cocrystallization, nanotechnology and solid dispersions drug delivery techniques and the benefits of using cocrystallization techniques over the above-mentioned techniques.:Various parameters including pharmaceutical, pharmacological and toxicological effects related to these mentioned drug delivery systems have been compared. Their advantages and disadvantages have been elaborated.:For drug delivery purpose, the cocrystallization process has numerous advantages over nanotechnology and solid dispersions drug delivery techniques discussed in the text. Cocrystallization is a newer technique that can modify the physicochemical and pharmaceutical properties of active pharmaceutical ingredients (API) with low solubility, low stability or sensitivity toward environmental hazards like temperature, moisture or photostability issues. During cocrystallization, the drug and the coformer interact with each other non-covalently in a fixed stoichiometric ratio. The availability of a large number of coformers makes this technique to be favorable for the researchers in designing cocrystals of newer and older API’s.:Although solid dispersions and nanotechnology techniques are being utilized to a larger extent, still there are some drawbacks of these techniques like stability, toxicological factors and protection from environmental factors that need to be considered, while the cocrystallization process drastically modifies the various pharmaceutical parameters without altering the pharmacological properties of API’s. Here in this review, we performed a comparative analysis between nanotechnology, solid dispersion and cocrystallization techniques along with the importance of cocrystallization in the modification of drug profile and various applications in the pharmaceutical and allied industry.
The Impact of Adverse Childhood Experiences (ACEs) on Suicidal Ideation and Suicide Attempts in an Inpatient Adolescent Sample
Authors: Benczkowski Tara , Kostoroski Christine , Stabile Mackenzie , Holler Karen 
Published: January 2021

Background:
Suicidal ideation (SI) and suicide attempts (SAs) among adolescents are a significant public health concern worldwide. The current study extends previous research by exploring the association between adverse childhood experiences (ACEs) and SI and SAs in a sample of inpatient adolescents as well as identifying specific predictors for increased risk of SI and SAs.

Methods:
Associations between ACE scores and self-reported SI and SAs were explored in a sample of 154 inpatient adolescents via clinical interview and by analyzing the association between cumulative ACE scores and scores on the Suicidal Tendency scale of a larger personality measure. We also tested for independent relationships between 19 ACEs and SI and SAs to determine unique predictors for suicidality.

Results:
One-way ANOVA analyses revealed that those who attempted suicide reported significantly more ACEs compared to those who did not attempt suicide. Witnessing violence in the home, school, or neighborhood and experiences of discrimination increased one’s likelihood to attempt suicide by two to threefold, while sexual abuse, neglect, and physical abuse increased this likelihood by three-to-fourfold. Stepwise linear regression analyses demonstrated that emotional abuse, living with someone who had mental health problems or attempted suicide were most associated with elevated Suicidal Tendency scores on a personality measure.

Conclusions:
Early identification, education and intervention are imperative to limit or eliminate ACEs from occurring. The impact of cumulative as well as specific ACEs on suicide risk should be closely considered as areas for such intervention. Areas for future research include extending to include more diverse populations such as the LGBTQ community as well as more ethnically and racially diverse populations.
Nanoparticulate Mycophenolic Acid Eye Drops - Analytical Validation of a High Performance Liquid Chromatography Assay and Stability Studies
Authors: Al-Kulabi Ali , Gooden Louis , Uchegbu Ijeoma F. 
Published: January 2021

Background:
Mycophenolic acid (MPA), an immunosuppressive agent, is used orally to
reduce corneal graft rejection. However, its oral use is associated with gastrointestinal side effects.

Objectives:
This study aims to prepare: MPA nanoparticle eye drops and a validated analytical
method.

Methods:
Aqueous MPA eye drops were prepared by nanoencapsulation of MPA using nanomerics
MET (N-palamitoyl-N-monomethyl-N,N-dimethyl-N,N,N-trimethyl-6-O-glycolchitosan) at a
MET and MPA ratio of 7.5: 1 g g-1 in the presence of glycerol (2.75% w/w). A validated MPA formulation
drug substance assay was then conducted.

Results:
MET-MPA formulations were prepared as well as a validated assay. Assay validation parameters
for the analysis of MPA in the formulation were satisfactory [Plate count = 16458, capacity
Factor = 2.4, Tailing Factor = 1.02, linearity = 0.999 (0.016-0.5 mg mL-1), limit of detection =
0.056 mg mL-1, limit of quantification = 0.17 mg mL-1, accuracy = 98%, intraday and interday relative
standard deviation = 0.45% and 4% respectively]. The candidate formulation (z-average mean
= 66 ± 0.4 nm, polydispersity index = 0.12 ± 0.012, drug content = 1.14 ± 0.003 mg mL-1, zeta potential
= +8.5 ± 1.4 mV, pH = 7.4 ± 0.02, osmolarity = 309 ± 1.5 mOSm L-1, viscosity = 1.04 ±
0.001 mPa.s) was then found to be stable for 14 days with respect to drug content at refrigeration,
room and accelerated (40ºC) temperature. All other formulation parameters were within the ocular
comfort range.

Conclusions:
A validated assay (ICH and US FDA guidelines) for new MPA nanoparticle eye
drops has been developed.
PEMBELAJARAN GERBANG LOGIKA DASAR BERBANTUAN MOBILE DI SEKOLAH MENENGAH KEJURUAN
Authors: Marsyaly Farah Puspa 
Published: January 2021

Makalah ini merupakan bagian dari penelitian dengan tujuan untuk mengetahui dampak media pembelajaran mobile untuk penguasaan gerbang logika dasar dalam proses pembelajaran di SMK. Penelitian ini merupakan penelitian pengembangan menggunakan pendekatan ADDIE untuk pengembangan materi dan pendekatan Waterfall Pressman untuk pengembangan perangkat lunak. Subjek dari penelitian ini yaitu 27 siswa kelas XI pada SMK Muhammadiyah Kudus. Data diperoleh menggunakan tes. Hasil dari validitas, reliabilitas, daya beda, dan indeks kesukaran tes diketahui masing-masing sebesar 0.492, 0.810, 0.373, dan 0.594. Data yang telah diperoleh dianalisis menggunakan uji Wilcoxon dan nilai gain. Hasil penelitian ini dapat diketahui bahwa media pembelajaran mobile berdampak pada penguasaan gerbang logika dasar dengan nilai signifikansi posttest terhadap 0.008 pada dan juga ditunjukkan dari skor gain sebesar 37.04%, yang berarti terdapat peningkatan dalam proses pembelajaran pada mata pelajaran gerbang logika dasar. Kata kunci: Pembelajaran Mobile, Gerbang Logika Dasar
SMART REARVIEW SEBAGAI PROTEKSI HELM GUNA MENCEGAH MARAKNYA PENCURIAN
Authors: Huda Nurul 
Published: January 2021

Perkembangan transportasi di era globalisasi terus meningkat. Kepemilikan berbagai jenis transportasi di indonesia menunjukan peningkatan dari tahun ketahun, terutama kepemilikan sepeda motor. Berkembangnya kepemilikan sepeda motor seiring dengan kepemilikan helm. Terus berkembangnya kepemilikan helm dengan berbagai jenis, menimbulkan angka pencurian helm semakin meningkat. Banyaknya kasus pencurian helm meresahkan kalangan masyarakat. Solusi dari permasalahan di atas dapat diatasi dengan menambahkan perangkat tambahan pada sepion sepeda motor. Inovasi alat tersebut yaitu smart rearview sebagai proteksi helm guna mencegah maraknya pencurian. Pelaksanaan program terdiri dari 5 tahapan yaitu studi literatur, persiapan alat dan bahan, perencanaan alat, pembuatan alat, dan pengujian alat. Komponen utama yang digunakan smart rearview yaitu: (1) Sensor ultrasonik sebagai pendeteksi helm; (2) Buzzer sebagai alarm saat terjadi pencurian; (3) Arduino nano sebagai controller; (4) Modul SIM 900 untu mengirimkan SMS ke pengguna saat terjadi pencurian; (5) Remote Switch untuk menghidupkan dan mematikan smart rearview. Output yang diharapkan dengan adanya smart rearview ini yaitu mencegah terjadinya pencurian helm. Kata kunci: helm, pencurian, sensor, alarm