bluuebunny/crossref_metadata_2025_split huggingface dataset:
Politics, Research Design, and the ‘Architecture’ of Criminal Careers Studies
Authors: Farrall Stephen 
Published: March 2021

Abstract
Criminal careers research is one of the bedrocks—if not the bedrock—of criminology. It remains a key focal point of criminological research and has embraced ideas and theories from sociology, psychology, psychiatry and urban and community studies. Despite the widening of the landscape of what might be termed ‘the criminological enterprise’ (to include victimology, prisons research, punishment, deterrence and environmental criminology), criminal careers (now differentiated into studies of onset, persistence and desistance) remains a key plank of criminology. This article critiques the research design of longitudinal studies of criminal careers, arguing that a key explanatory factor has been consistently overlooked in criminal careers research due, in part, to the research design of such studies. In focussing on the role of politically motivated changes to economic policies and the restructuring of the industrial base this produced, I empirically relate individual offending careers to politics in ways very few have done before. The article touches upon a series of suggestions for how empirical studies of criminal careers might be improved.
Impact of co-morbidity on reoperation or death within 90 days of surgery for oesophageal cancer
Authors: Cheng Z , Johar A , Gottlieb-Vedi E , Nilsson M , Lagergren J , Lagergren P 
Published: March 2021

Abstract

Background
The impact of preoperative co-morbidity on postoperative outcomes in patients with oesophageal cancer is uncertain. A population-based and nationwide cohort study was conducted to assess the influence of preoperative co-morbidity on the risk of reoperation or mortality within 90 days of surgery for oesophageal cancer.

Methods
This study enrolled 98 per cent of patients who had oesophageal cancer surgery between 1987 and 2015 in Sweden. Modified Poisson regression models provided risk ratios (RRs) with 95 per cent confidence intervals (c.i.) to estimate associations between co-morbidity and risk of reoperation or death within 90 days of oesophagectomy. The RRs were adjusted for age, sex, educational level, pathological tumour stage, neoadjuvant therapy, annual hospital volume, tumour histology and calendar period of surgery.

Results
Among 2576 patients, 446 (17.3 per cent) underwent reoperation or died within 90 days of oesophagectomy. Patients with a Charlson Co-morbidity Index (CCI) score of 2 or more had an increased risk of reoperation or death compared with those with a CCI score of 0 (RR 1.78, 95 per cent c.i. 1.44 to 2.20), and the risk increased on average by 27 per cent for each point increase of the CCI (RR 1.27, 1.18 to 1.37). The RR was increased in patients with pulmonary disease (RR 1.66, 1.36 to 2.04), cardiac disease (RR 1.37, 1.08 to 1.73), diabetes (RR 1.50, 1.14 to 1.99) and cerebral disease (RR 1.40, 1.06 to 1.85).

Conclusion
Co-morbidity in general, and pulmonary disease, cardiac disease, diabetes and cerebral disease in particular, increased the risk of reoperation or death within 90 days of oesophageal cancer surgery. This highlights the value of tailored patient selection, preoperative preparation and postoperative care.
Discriminatory ability of next-generation tau PET tracers for Alzheimer’s disease
Authors: Yap Steven Y , Frias Barbara , Wren Melissa C , Schöll Michael , Fox Nick C , Årstad Erik , Lashley Tammaryn , Sander Kerstin 
Published: March 2021

Abstract
A next generation of tau PET tracers for the imaging of Alzheimer’s disease and other dementias has recently been developed. Whilst the new compounds have now entered clinical studies, there is limited information available to assess their suitability for clinical applications. Head-to-head comparisons are urgently needed to understand differences in the radiotracer binding profiles. We characterized the binding of the tau tracers PI2620, RO948, MK6240 and JNJ067 in human post-mortem brain tissue from a cohort of 25 dementia cases and age-matched controls using quantitative phosphorimaging with tritium-labelled radiotracers in conjunction with phospho-tau specific immunohistochemistry. The four radiotracers depicted tau inclusions composed of paired helical filaments with high specificity, both in cases with Alzheimer’s disease and in primary tauopathy cases with concomitant Alzheimer’s disease pathology. In contrast, cortical binding to primary tauopathy in cases without paired helical filament tau was found to be within the range of age-matched controls. Off-target binding to monoamine oxidase B has been overcome, as demonstrated by heterologous blocking studies in basal ganglia tissue. The high variability of cortical tracer binding within the Alzheimer’s disease group followed the same pattern with each tracer, suggesting that all compounds are suited to differentiate Alzheimer’s disease from other dementias.
Proof Automation in the Theory of Finite Sets and Finite Set Relation Algebra
Authors: Cristiá Maximiliano , Katz Ricardo D , Rossi Gianfranco 
Published: March 2021

Abstract
$\{log\}$ (‘setlog’) is a satisfiability solver for formulas of the theory of finite sets and finite set relation algebra (FS&RA). As such, it can be used as an automated theorem prover for this theory. $\{log\}$ is able to automatically prove a number of FS&RA theorems, but not all of them. Nevertheless, we have observed that many theorems that $\{log\}$ cannot automatically prove can be divided into a few subgoals automatically dischargeable by $\{log\}$. The purpose of this work is to present a prototype interactive theorem prover (ITP), called $\{log\}$-ITP, providing evidence that a proper integration of $\{log\}$ into world-class ITP’s can deliver a great deal of proof automation concerning FS&RA. An empirical evaluation based on 210 theorems from the TPTP and Coq’s SSReflect libraries shows a noticeable reduction in the size and complexity of the proofs with respect to Coq.
Current progress in clinical, molecular, and genetic aspects of adult fibromuscular dysplasia
Authors: Persu Alexandre , Dobrowolski Piotr , Gornik Heather L , Olin Jeffrey W , Adlam David , Azizi Michel , Boutouyrie Pierre , Bruno Rosa Maria , Boulanger Marion , Demoulin Jean-Baptiste , Ganesh Santhi K , J. Guzik Tomasz , Januszewicz Magdalena , Kovacic Jason C , Kruk Mariusz , de Leeuw Peter , Loeys Bart L , Pappaccogli Marco , Perik Melanie H A M , Touzé Emmanuel , Van der Niepen Patricia , Van Twist Daan J L , Warchoł-Celińska Ewa , Prejbisz Aleksander , Januszewicz Andrzej 
Published: March 2021

Abstract
Fibromuscular dysplasia (FMD) is a non-atherosclerotic vascular disease that may involve medium-sized muscular arteries throughout the body. The majority of FMD patients are women. Although a variety of genetic, mechanical, and hormonal factors play a role in the pathogenesis of FMD, overall, its cause remains poorly understood. It is probable that the pathogenesis of FMD is linked to a combination of genetic and environmental factors. Extensive studies have correlated the arterial lesions of FMD to histopathological findings of arterial fibrosis, cellular hyperplasia, and distortion of the abnormal architecture of the arterial wall. More recently, the vascular phenotype of lesions associated with FMD has been expanded to include arterial aneurysms, dissections, and tortuosity. However, in the absence of a string-of-beads or focal stenosis, these lesions do not suffice to establish the diagnosis. While FMD most commonly involves renal and cerebrovascular arteries, involvement of most arteries throughout the body has been reported. Increasing evidence highlights that FMD is a systemic arterial disease and that subclinical alterations can be found in non-affected arterial segments. Recent significant progress in FMD-related research has led to improve our understanding of the disease’s clinical manifestations, natural history, epidemiology, and genetics. Ongoing work continues to focus on FMD genetics and proteomics, physiological effects of FMD on cardiovascular structure and function, and novel imaging modalities and blood-based biomarkers that can be used to identify subclinical FMD. It is also hoped that the next decade will bring the development of multi-centred and potentially international clinical trials to provide comparative effectiveness data to inform the optimal management of patients with FMD.
Stylet Probing Behavior of Two Bactericera (Hemiptera: Psylloidea: Triozidae) Species on Host and Nonhost Plants
Authors: Mustafa Tariq , Horton David R , Cooper W Rodney , Zack Richard S , Thinakaran Jenita , Karasev Alexander V , Munyaneza Joseph E 
Published: March 2021

Abstract
Understanding host use by psyllids (Hemiptera: Psylloidea) benefits from comparative studies of behavior on host and nonhost plant species. While most psyllid species develop on one or a few closely related plant species, some species are generalized enough to develop on species across plant families. We used electropenetography (EPG) technology to compare probing activities of an oligophagous psyllid (Bactericera cockerelli (Šulc)) and a host-specialized psyllid (Bactericera maculipennis) on two species of Solanaceae (potato, Solanum tuberosum L. and matrimony vine, Lycium barbarum L.) and two species of Convolvulaceae (field bindweed, Convolvulus arvensis L. and sweet potato, Ipomoea batatas). Bactericera cockerelli develops on all four species, albeit with longer development times on Convolvulaceae. Bactericera maculipennis develops only on Convolvulaceae. Bactericera cockerelli fed readily from phloem of all four species, but the likelihood of entering phloem and duration of time in phloem was reduced on suboptimal hosts (Convolvulaceae) relative to behavior on Solanaceae. We observed instances of cycling between bouts of phloem salivation and ingestion in assays of optimal (Solanaceae) hosts not observed on Convolvulaceae. The Convolvulaceae-specialized B. maculipennis (Crawford) failed to feed from phloem of nonhosts (Solanaceae). Both psyllid species readily ingested from xylem of all plant species, irrespective of host status. Our finding that phloem feeding by B. maculipennis did not occur on potato has implications for understanding epidemiology of phloem-limited psyllid-vectored plant pathogens. Our results also showed that EPG assays detect subtle variation in probing activities that assist in understanding host use by psyllids.
R&D Heterogeneity and the Impact of R&D Subsidies*
Authors: Galaasen Sigurd Mølster , Irarrazabal Alfonso 
Published: March 2021

Abstract
In this paper we study the determinants of R&D heterogeneity and the economic impact of R&D subsidies. We estimate a Schumpeterian growth model featuring firms with heterogeneous innovation efficiencies. The model fits well the R&D investment distribution, and the frequency and relative size of R&D performers. Using the model, we study the impact of a Norwegian R&D reform targeting firms with R&D spending below a certain threshold. The size-dependent subsidy increases aggregate R&D investment by 11.7%, but reduces growth and welfare. In contrast, a uniform subsidy stimulates investment, growth and welfare.
Ethnic minorities and COVID-19: examining whether excess risk is mediated through deprivation
Authors: Razieh Cameron , Zaccardi Francesco , Islam Nazrul , Gillies Clare L , V. Chudasama Yogini , Rowlands Alex , Kloecker David E , Davies Melanie J , Khunti Kamlesh , Yates Thomas 
Published: March 2021

Abstract

Background
People from South Asian and black minority ethnic groups are disproportionately affected by the COVID-19 pandemic. It is unknown whether deprivation mediates this excess ethnic risk.

Methods
We used UK Biobank with linked COVID-19 outcomes occurring between 16th March 2020 and 24th August 2020. A four-way decomposition mediation analysis was used to model the extent to which the excess risk of testing positive, severe disease and mortality for COVID-19 in South Asian and black individuals, relative to white individuals, would be eliminated if levels of high material deprivation were reduced within the population.

Results
We included 15 044 (53.0% women) South Asian and black and 392 786 (55.2% women) white individuals. There were 151 (1.0%) positive tests, 91 (0.6%) severe cases and 31 (0.2%) deaths due to COVID-19 in South Asian and black individuals compared with 1471 (0.4%), 895 (0.2%) and 313 (0.1%), respectively, in white individuals. Compared with white individuals, the relative risk of testing positive for COVID-19, developing severe disease and COVID-19 mortality in South Asian and black individuals were 2.73 (95% CI: 2.26, 3.19), 2.96 (2.31, 3.61) and 4.04 (2.54, 5.55), respectively. A hypothetical intervention moving the 25% most deprived in the population out of deprivation was modelled to eliminate between 40 and 50% of the excess risk of all COVID-19 outcomes in South Asian and black populations, whereas moving the 50% most deprived out of deprivation would eliminate over 80% of the excess risk of COVID-19 outcomes.

Conclusions
The excess risk of COVID-19 outcomes in South Asian and black communities could be substantially reduced with population level policies targeting material deprivation.
Ultra-conserved sequences in the genomes of highly diverse Anopheles mosquitoes, with implications for malaria vector control
Authors: O’Loughlin Samantha M , Forster Annie J , Fuchs Silke , Dottorini Tania , Nolan Tony , Crisanti Andrea , Burt Austin 
Published: March 2021

Abstract
DNA sequences that are exactly conserved over long evolutionary time scales have been observed in a variety of taxa. Such sequences are likely under strong functional constraint and they have been useful in the field of comparative genomics for identifying genome regions with regulatory function. A potential new application for these ultra-conserved elements (UCEs) has emerged in the development of gene drives to control mosquito populations. Many gene drives work by recognizing and inserting at a specific target sequence in the genome, often imposing a reproductive load as a consequence. They can therefore select for target sequence variants that provide resistance to the drive. Focusing on highly conserved, highly constrained sequences lowers the probability that variant, gene drive-resistant alleles can be tolerated. Here, we search for conserved sequences of 18 bp and over in an alignment of 21 Anopheles genomes, spanning an evolutionary timescale of 100 million years, and characterize the resulting sequences according to their location and function. Over 8000 UCEs were found across the alignment, with a maximum length of 164 bp. Length-corrected gene ontology analysis revealed that genes containing Anopheles UCEs were over-represented in categories with structural or nucleotide-binding functions. Known insect transcription factor binding sites were found in 48% of intergenic Anopheles UCEs. When we looked at the genome sequences of 1142 wild-caught mosquitoes, we found that 15% of the Anopheles UCEs contained no polymorphisms. Our list of Anopheles UCEs should provide a valuable starting point for the selection and testing of new targets for gene-drive modification in the mosquitoes that transmit malaria.
Policy exclusion or confusion? Perspectives on universal health coverage for migrants and refugees in South Africa
Authors: White Janine A , Rispel Laetitia C 
Published: March 2021

Abstract
Notwithstanding the promise of the inclusivity of universal health coverage (UHC), the integration of migrants and refugees into host countries’ health systems remains elusive and contested. In South Africa, there is insufficient scholarly attention on UHC, migrants and refugees, given the country’s strategic importance in Africa and the envisaged implementation of the National Health Insurance (NHI) system. In this paper, a social exclusion conceptual framework is used to explore whether South African legislation, health policies and perspectives or actions of health policy actors facilitate UHC for migrants and refugees or exacerbate their exclusion. We combined a review of legislation and policies since 1994, with semi-structured interviews with 18 key informants from government, academia, civil society organizations and a United Nations organization. We used thematic analysis to identify themes and sub-themes from the qualitative data.
The South African Constitution and the National Health Act facilitate UHC, while the Immigration Act and the 2019 NHI Bill make the legal status of migrants the most significant determinant of healthcare access. This legislative disjuncture is exacerbated by variations in content, interpretation and/or implementation of policies at the provincial level. Resource constraints in the public health sector contribute to the perceived dysfunctionality of the public healthcare system, which affects the financial classification, quality of care and access for all public sector patients. However, migrants and refugees bear the brunt of the reported dysfunctionality, in addition to experiences of medical xenophobia. These issues need to be addressed to ensure that South Africa’s quest for UHC expressed through the NHI system is realized.
Asset map in a Chilean Health Promoting University: ‘a strategy for revitalization’
Authors: Pérez-Wilson Patricia , Marcos-Marcos Jorge , Carrasco-Portiño Mercedes , Ruiz-Cantero María Teresa , Alvarez-Dardet Carlos 
Published: March 2021

Summary
Health Promoting Universities (HPUs) are more likely to perform actions intended to change habits and increase personal empowerment, than they are to develop community actions. The objective of this research is to create an asset map to visualize collective actions in a Chilean HPU. A qualitative study, based on the ABCD model was conducted. There were 149 people, distributed into 48 semi-structured interviews and 14 focus groups, who participated in this study (students, employees, ex-students and retirees). An asset map was elaborated, identifying the contributions of residents, associations and organizations, local institutions, physical resources, economic assets and local culture and with a new category, ‘connecting assets’. These categories show the range of resources in a university. According to the participants, the questions on asset identification were a tool for reflection, and by giving their opinions and discovering or drawing attention to new resources, they gained a better understanding of the assets in the university. Several participants stated that these talks could generate a positive emotional environment, which boosted their wellbeing. There were gender- and group-based differences in how the assets were valued. Students stressed assets related to services and benefits from the institution, green areas, and collective spaces. Employees, retirees and ex-students emphasized assets related to belonging, identity and traditions. Men appreciated openness and privacy in physical spaces. Women highlighted assets related to the institution. The resulting map, displays a range of resources that can help the university develop new possibilities for comprehensive and collective actions that would revitalize the HPU strategy.
Indigenous Youth Mentorship Program: essential characteristics of a Canadian multi-site community-university partnership with Indigenous communities
Authors: Lopresti Sabrina , Willows Noreen D , Storey Kate E , McHugh Tara-Leigh F ,   IYMP National Team
Published: March 2021

SummaryThe Indigenous Youth Mentorship Program (IYMP) is a peer-led health promotion program grounded in the teachings of Indigenous scholars. IYMP is delivered as a multi-sited community-university partnership (CUP) with Indigenous communities across Canada for elementary students. A local young adult health leader and high school youth mentors offer students healthy snacks, physical activity games, relationship building activities and traditional cultural teachings. IYMP aims to improve children’s health and wellbeing and empower Indigenous youth and communities. The purpose of this descriptive qualitative study was to describe the essential characteristics of this multi-sited CUP as perceived by the IYMP principal investigators (PIs). Key informant interviews were conducted with 5 IYMP PIs (2 Indigenous) and analysed using content analysis. The overarching theme was forming a community of practice (CoP), where people with a common interest share best practices as they interact regularly. Four sub-themes were shared interest for Indigenous health/wellbeing and social justice, relationships, mentorship and taking a decolonizing research approach. The IYMP CoP allowed mentorship to occur across regions. The essential characteristics that made the IYMP CUPs successful could be used to inform other multi-sited CUPs with Indigenous communities. Those with mutual interests in Indigenous health and partnership with Indigenous communities could consider forming a CoP. Within a newly formed CoP, relationships and mentorship can be developed through discussion and activities. It is imperative within the CoP to take a decolonizing approach to research and acknowledge the impact that colonial policies and practices have had on generations of Indigenous peoples.
New Dimensions for Animal Communication Networks:Space and Time
Authors: Reichert Michael S , Enriquez Maya S , Carlson Nora V 
Published: March 2021

Synopsis
Communication is a social process and usually occurs in a network of signalers and receivers. While social network analysis has received enormous recent attention from animal behaviorists, there have been relatively few attempts to apply these techniques to communication networks. Communication networks have the potential to offer novel insights into social network studies, and yet are especially challenging subjects, largely because of their unique spatiotemporal characteristics. Namely, signals propagate through the environment, often dissociating from the body of the signaler, to influence receiver behavior. The speed of signal propagation and the signal’s active space will affect the congruence of communication networks and other types of social network; in extreme cases, the signal may persist and only first be detected long after the signaler has left the area. Other signals move more rapidly and over greater distances than the signaler could possibly move to reach receivers. We discuss the spatial and temporal consequences of signaling in networks and highlight the distinction between the physical location of the signaler and the spread of influence of its signals, the effects of signal modality and receiver sensitivity on communication network properties, the potential for feedbacks between network layers, and approaches to analyzing spatial and temporal change in communication networks in conjunction with other network layers.