bluuebunny/crossref_metadata_2025_split huggingface dataset:
Das Exposom charakterisiert die Auswirkungen unserer Umwelt auf Stoffwechsel und Gesundheit
Authors: Daiber Andreas , Kuntic Marin , Lelieveld Jos , Hahad Omar , Münzel Thomas 
Published: December 2021

ZusammenfassungAktuelle Befunde der großen globalen epidemiologischen Studien wie dem „Global Burden of Disease“-Projekt legen nahe, dass bereits jetzt nahezu ⅔ der jährlichen globalen Todesfälle ursächlich auf chronische nicht übertragbare Erkrankungen wie Atherosklerose oder Diabetes zurückzuführen sind. Dies liegt vor allem an der Überalterung der Menschen in westlichen Gesellschaften, aber auch einer zunehmenden Belastung durch Boden-, Wasser- und Luftverschmutzung, Lärmbelastung, mentale Stressfaktoren und weitere Umweltrisikofaktoren. Vor etwa 15 Jahren wurde das Exposom-Konzept etabliert, um die Auswirkungen unserer Umwelt auf die Gesundheit zu erforschen. Das Exposom beschreibt dabei die Summe aller Expositionen, die lebenslang auf uns einwirken und dabei biochemische und metabolische Prozesse in unserem Körper überwiegend ungünstig verändern und so zu Gesundheitsschäden und frühzeitigen Todesfällen beitragen. Mit dieser Übersicht wird das Exposom-Konzept anhand von ausgewählten
Studien erklärt und seine Bedeutung für die zukünftige Gesundheitsforschung sowie die präventive Medizin, vor allem im Hinblick auf kardiovaskuläre Erkrankungen und Therapie, erläutert.
Exploring Pleiotropic Effects of Lipid Modifiers and Targets on Measures of the Coagulation System with Genetics
Authors: Schooling C. Mary , Au Yeung Shiu Lun , Zhao Jie V. 
Published: December 2021

Abstract
Background Statins have long been suspected to have pleiotropic effects via thrombotic factors. Randomized controlled trials are too limited to be definitive. We examined the associations of genetically mimicking effects of statins, PCSK9 inhibitors, and alternative lipid targets (in genes LDLR, APOC3, and LPL) on key indicators of coagulation system function, i.e., prothrombin time (PT) and activated partial thromboplastin time (aPTT).
Methods We assessed the effect of established genetic mimics of effects of lipid modifiers and alternative lipid treatment targets on PT (n = 58,110) and aPTT (n = 37,767), all transformed to z-scores, using Mendelian randomization taking advantage of Biobank Japan. Ischemic heart disease (IHD) was a control outcome.
Results Genetically mimicked effects of statins increased PT by 0.31 standard deviation (SD) per SD increase in low-density lipoprotein (95% confidence interval [CI]: 0.10–0.51) based on rs12916 but did not affect aPTT. Genetically mimicking effects of targeting LDLR increased PT based on rs688 (0.33 SD per SD increase in triglyceride, 95% CI: 0.03–0.63) but did not affect aPTT. Genetically mimicking effects of PCSK9 inhibitors or targeting APOC3 or LPL had no effect on PT or aPTT. Genetically mimicking effects of statins, PCSK9 inhibitors, and alternative lipid targets reduced risk of IHD in Biobank Japan.
Conclusion Statins, and possibly targeting LDLR, may also act via a coagulation cascade factor, likely specific to the extrinsic or common pathway. Further elucidation of the mechanistic pathway may facilitate development of new interventions and inform use of statins particularly in relation to use of other anticoagulants.
Radical Vaginal Trachelectomy
Authors: Saito Tsuyoshi , Matsuura Motoki , Tamate Masato , Iwasaki Masahiro , Mariya Tasuku 
Published: December 2021

AbstractRecently, radical vaginal hysterectomy (RVH) has developed into laparoscopically assisted radical vaginal hysterectomy (LARVH), which is associated with the laparoscopical procedure, and it is applied as radical vaginal trachelectomy and semi-radical vaginal hysterectomy. LARVH is indicated for patients with stage IB1 and IIA1 cervical carcinoma, especially those with a tumor size of less than 2 cm, because the cardinal ligaments cannot be resected widely. Although RVH that is associated with laparoscopic pelvic lymphadenectomy is the most used surgical procedure, radical trachelectomy may be performed either abdominally or vaginally (laparoscopic or robotic). One report found that the pregnancy rate was higher in patients who underwent minimally invasive or radical vaginal trachelectomy than in those who underwent radical abdominal trachelectomy.
Managing the Digital Disruption Associated with COVID-19-Driven Rapid Digital Transformation in Brisbane, Australia
Authors: Dyda Amalie , Fahim Magid , Fraser Jon , Kirrane Marianne , Wong Ides , McNeil Keith , Ruge Maree , Lau Colleen L. , Sullivan Clair 
Published: December 2021

Abstract
Background The COVID-19 pandemic has forced rapid digital transformation of many health systems. These innovations are now entering the literature, but there is little focus on the resulting disruption.
Objective We describe the implementation of digital innovations during the COVID-19 response of Australia's largest health service, Metro North (in Brisbane, Queensland), the challenges of the subsequent digital disruption, how these were managed, and lessons learned.
Methods Prior to the COVID-19 pandemic, the Australian state of Queensland created the Queensland Digital Clinical Charter, which provides guidance for the development of digital health programs. The guidelines utilize three horizons: digitizing workflows, leveraging digital data to transform clinical care, and reimagining new and innovative models of care. The technical response to COVID-19 in Metro North is described across these horizons. The rapid digital response caused significant disruption to health care delivery; management of the disruption and the outcomes are detailed. This is a participatory action research project, with members of the research team assisting with leading the implementation project informing the case report content.
Results Several digital innovations were introduced across Metro North during the COVID-19 response. This resulted in significant disruption creating digital hypervigilance, digital deceleration, data discordance, and postdigital “depression.” Successful management of the digital disruption minimized the negative effects of rapid digital transformation, and contributed to the effective management of the pandemic in Queensland.
Conclusion The rapid digital transformation in Metro North during COVID-19 was successful in several aspects; however, ongoing challenges remain. These include the need to improve data sharing and increase interoperability. Importantly, the innovations need to be evaluated to ensure that Metro North can capitalize on these changes and incorporate them into long-term routine practice. Moving forward, it will be essential to manage not only the pandemic, but increasingly, the resultant digital disruption.
Metaphors, powerlessness and online aggression
Authors: Ho Janet 
Published: December 2021

AbstractA lockdown was imposed in Wuhan, China, the alleged epicentre of the COVID-19 outbreak, on 23 January 2020. Rattled by the short notice and severity of the restrictions, many grabbed the last opportunity to escape, an act widely criticised on Weibo, China’s popular microblogging site. This study aims to examine the unsavoury discourse deployed by Weibo users to express impoliteness and discursively construct negative identities of the lockdown escapees. Posts on Weibo criticising, reporting and threatening the escapees were analysed, revealing that the escapees were dehumanised through vivid animal metaphors to highlight their irresponsibility and call for their punishment. Animal metaphors can co-occur with various impoliteness triggers to intensify offensiveness, heightening the hostility of interlocutors towards a target.This use of metaphors also showcases online users’ anger, distrust, and hatred towards the escapees, their solidarity-seeking behaviour online and their irrationality.
The phraseology of wine and olive oil tasting notes
Authors: López Arroyo Belén , Sanz Valdivieso Lucía 
Published: December 2021

Abstract
Specialized genres are bound to the communicative context of their discourse community. However, certain genres
extend beyond one specific domain, remaining unchanged at different linguistic levels across domains. That seems to be the case of
wine and olive oil tasting notes since both analyze and evaluate sensory descriptions. The present study aims at describing and
comparing lexical chunks of wine and olive oil tasting notes at a semantic level to show if there is variation in the same genre
across domains; we will not only describe, classify and compare lexical chunks, but also identify the way this knowledge is
structured and construed in the same genre in both domains. We will test our methodology in a corpus of English tasting notes from
both genres written by three different writer profiles: professionals, amateurs and wineries/mills. Our results will be useful for
scholars as well as technical writers when writing tasting notes.
Research and Application of Full-Link Management Intellectual Inspection Robot with Remote Pre-Control and Information Digitization
Authors: Qiu Yutao , Qian Kai , Liang Liuming , Weng Zhangli , Huang Zhen , Yan Yuchen 
Published: December 2021

Abstract
With the development of intelligent power grid maintenance, inspection robot has been widely used for its integrated perception and remote pre-control. Aiming at the problems of the weak information interaction capacity and the low correlation with digital requirements of inspection operation, a kind of Full-Link Management Intellectual Inspection Robot is proposed. The article introduces the system structure, function modules, engineering application and debugging process. It is with low response delay and strong anti-interference ability. The correct recognition rate of violations reached 88.2 %, meanwhile provided with the function of evaluation and early warning of workers’ unsafe behavior. The Full-Link Management Intellectual Inspection Robot has a broad application foreground in power grid maintenance.
KM3NeT sensitivity to low energy astrophysical neutrinos
Authors: de Wasseige G. 
Published: December 2021

Abstract
KM3NeT, a new generation of neutrino telescope, is currently being deployed in the Mediterranean Sea. While its two sites, ORCA and ARCA, were respectively designed for the determination of neutrino mass hierarchy and high-energy neutrino astronomy, this contribution presents a study of the detection potential of KM3NeT in the MeV-GeV energy range. At these low energies, the data rate is dominated by low-energy atmospheric muons and environmental noise due to bioluminescence and K-40 decay. The goal of this study is to characterize the environmental noise in order to optimize the selection of low-energy neutrino interactions and increase the sensitivity of KM3NeT to transient astrophysical phenomena, such as close-by core-collapse supernovae, solar flares, and extragalactic transients. In this contribution, we will study how using data science tools might improve the sensitivity of KM3NeT in these low-energy neutrino searches. We will first introduce the data sets and the different variables used to characterize KM3NeT’s response to the environmental noise. We will then compare the efficiency of various tools in identifying different components in the environmental noise and in disentangling low-energy neutrino interactions from the background events. We will conclude with the implication of low-energy neutrinos for future astrophysical transient searches.
A data-based machine learning approach for RPC time resolution study based on ToF reconstruction
Authors: Xie X.Y. , Xu H.L. , Li Q.Y. , Sun Y.J. 
Published: December 2021

Abstract
A data-based machine learning approach is proposed to study
the properties of time resolution of RPC detectors by measuring the
time of flight of cosmic muons. This method utilises a multi-layer
perceptron and a type of recurrent neural network called long
short-term memory. The neural network is trained with the waveforms
of RPC signals digitized by an oscilloscope at a sampling frequency
of 10 GHz and a 2 GHz bandwidth. A data augmentation approach is
implemented for labelling. Compared to the results from
conventional waveform analysis, this approach achieves a better time
resolution of 1-mm gap RPCs. Based on the data, the approach has a
generalisation capacity for performance studies of other timing
detectors.
Effect of Ground Granulated Blast Furnace Slag, Silica Fume and Nano Silica on the Strength & Durability Properties of Concrete: A Contemporary Review
Authors: Wani Absar Yousuf , Bhandari Mohit 
Published: December 2021

Abstract
This paper provides a contemporary review of the usage of Ground Granulated Blast-furnace Slag (GGBS), Silica Fume, and Nano Silica in Materialistic form over the deterministic aspects of conventional concrete. The main purpose of this literature learning is to enumerate the effect of GGBS, Silica Fume, and Nano Silica on strength of concrete. The GGBS, Silica Fume and Nano-silica is a restored substitute as compared to orthodox additives like CaCl2 and SiO2 because of their effectiveness with a lesser amount of consumption. It was found that the GGBS, Silica Fume, and nano-silica have an optimistic effect on the unconfined compressive strength, flexural strength, split tensile strength of concrete.
Statistical Analysis and Development of Accident Prediction Model of Road Safety Conditions in Hisar City
Authors: Bamel Keshav , Dass Sachin , Jaglan Saurabh , Suthar Manju 
Published: December 2021

Abstract
The severity of road accidents is a big problem around the world, particularly in developing countries. Recognizing the major contributing variables can help reduce the severity of traffic accidents. This research uncovered new information as well as the most substantial target-specific factors related to the severity of road accidents. T-stat, P-value, Significance and other test values are determined to check the dependency of dependent variable on independent variable in order to obtain the most significant road accident variables. In this research, a comparative analysis of accident data from Hisar and Haryana are compared. According to the findings, Haryana’s accident severity index (46.20) was higher in 2019 than Hisar’s (36.01), while Hisar had fewer accidents per lakh population (33.34) than Haryana (38.40). The outcomes of the study were used to develop an effective and precise accident predicting model is developed for Hisar city and state Haryana using a statistical method. Four models were created using linear regression analysis, two each for Hisar and Haryana. These models produce good results with a margin of error that is within acceptable bounds (0-5%), allowing them to be used to predict future traffic accidents and deaths.
Removal of Turbidity and TDS from Wastewater by Using Natural Coagulants — A Review
Authors: Nisa A.Mehrun , Kishor Brij 
Published: December 2021

Abstract
The highest quantity of wastewater is produced from lather industries that is mixed with oil and other pollutants and under goes to the drains from sinks, toilets, laundries, showers, etc. The wastewater is usually classified as industrial wastewater or municipal wastewater. As the population of the earth is very huge, there is a requirement that the treatment of wastewater become necessary by using different techniques. The removal of TDS and Turbidity are here done by natural coagulants such as Strychnospotatorum, Passion fruit, Phaseolus Vulgaris, Chitosan, Cicer Arietinum, Cactus, Nirmali seeds, Vingna Mungo, Ripe Okra, Surjana seed powder (SSP), Orange peel, Moringa Oleifera, and Maize seed powder. This is found from the literature review that; Jar tests were prominently used in the coagulation-flocculation process for the removal TDS and Turbidity from wastewater. The objective of this review is to find out the scope of different natural coagulants as an alternative compared to other commercial chemical-based coagulants. It has been found from the literature review that these natural coagulants are alternative, cheaper, eco-friendly, and easy to use in wastewater treatment.
Solar-powered IoT based smart hydroponic nutrition management system using FARM
Authors: Wedashwara W. , Jatmika A. H. , Zubaidi A. , Arimbawa I. W. A. 
Published: December 2021

Abstract
Good nutrition and water conditions are significant in a hydroponic system. Nutrients in hydroponic systems are periodically re-mixed to target the right amount of TDS. The TDS amount needs to be regularly measured after the weather changes, namely temperature, humidity, light intensity, and rainfall. The research proposes developing a solar-powered Internet of Things (IoT) based Smart Hydroponic Nutrition Management System using Fuzzy Association Rule Mining (FARM). The system consists of an IoT connected to a TDS (Total Dissolved Solids) sensor, a relay module connected to two 5v mini pumps that supply AB Mix nutrients, and a solenoid valve to supply water. The IoT system is also connected to sensors for temperature and humidity, light intensity, and rainfall to record the causes of weather changes that cause changes in TDS in hydroponic water. FARM is used to extract fuzzy association rules (FAR) from IoT sensors. The system targets a TDS of 1200 for leafy plants such as lettuce. The system prototype was developed in a small 5×7cm single layer PCB using the wire-wrapping technique. The test results produce a standard deviation of 2.345 for the TDS average of 1196.17 and threshold 50. In one week of evaluation, three times of rain and four times of hot weather were considered to change the TDS, and seven actions of the relay module were carried out. FARM has extracted fuzzy rules with average support of 0.401 and confidence of 0.826.
The effect of method and dosage application of biofungicide extract of Legundi leaf fermented with Trichoderma harzianum fungus for control of Fusarium wilt disease on shallots
Authors: Sudantha I M , Sudirman  , Ernawati N M L 
Published: December 2021

Abstract
Legundi weed (Vitex trifolia) has the potential to be used as a biofungicide to control Fusarium wilt disease on shallots. For the manufacture of biofungoicides, legundi leaf extract was first fermented using the fungus Trichoderma harzianum. The aim of this study was to determine the effect of the method and dose of fermented Legundi leaf extract biofungicide on the Fusarium fungus that causes shallots wilt. The research was carried out in Senteluk Village, Batu Layar District, West Lombok Regency using an experimental method with a factorial randomized block design with two factors. As the main effect, namely the application of biofungicide fermented Legundi leaf extract consisting of two levels, namely: seed treatment before planting, and spraying treatment for plants aged 7 days after planting. Meanwhile, the simple effect is the application dose of fermented Legundi leaf extract biofungicide consisting of 5 levels, namely: 0.00 mL, 2.50 mL; 5.00 mL; 7.50 mL and 10.00 mL. The combination method and dose of fermented Legundi leaf extract biofungicide was repeated three times each, so there were 30 treatment combinations. The results obtained were the application of Legundi leaf extract biofungicides by soaking the seeds before planting at a starting dose of 2.50 mL to effectively control onion wilt disease. The applied biofungicide can increase plant height and increase the dry weight of the harvest.
Tuber and Organoleptic Characteristics of Four Potato Varieties Grown Off-season in Sajang Village, Sembalun
Authors: Nairfana I , Nikmatullah A , Sarjan M , Kisman  
Published: December 2021

Abstract
Quality of the tuber is an important factor determining utilization and economic values of the potato (Solanum tuberosum L.) plant. The acceptance of potato variety for industrial processing is determined by the dry matter, starch and reduced sugar contents as well as market acceptance of the products. These characteristics are influenced by the potato variety and cultivation season. This research aimed to evaluate the tuber and organoleptic properties of chips from four potato varieties grown during off-season, in Sajang Village of Sembalun District (at ca. 900 m above mean sea level). A plantation was undertaken at the end of rainy season in 2021, and comprised of four potato varieties, designated as McRusset, Ranger Russet, Chitra and Atlantic. After harvesting and stored at ambient temperature for 2 weeks, raw tubers were characterized for the dry matter, starch, and reduced sugar contents. The tubers were fried as french fries and chips, and sensory analysis were undertaken for likeliness in color, flavour, crispness and overall appearance. The different in properties of these four varieties and its industrial utilization is be presented and discussed in this paper.
Isolation of trymiristin from Myristica fragrans for natural product chemistry laboratory
Authors: Hakim A , Jamaluddin  , Al Idrus S W 
Published: December 2021

Abstract
This study aims generated natural products chemistry project laboratory for student in order to isolation trymiristin from Myristica fragrans. The skill of isolating trimyristin will be useful for students to obtain natural whitening raw materials derived from nutmeg. Various studies on the isolation can be used in natural products laboratory project. Students are directed to study literature related to trymiristin isolation procedures. Students practice skills of extraction, fractionation, purification, and structure elucidation of trymiristin. They were asked to design the laboratory activities. Manipulation of the liquor by soxhletation and recrystallization techniques proved to be a simple method to isolate trymiristin in low resource laboratory setting. The trymiristin was treated with structure elucidation NMR and infrared spectrometry. The laboratory method, comprising for 3 hours laboratory sessions, was a simple way for the students to understand the process of isolating trymiristin.
Exploring the phytochemical and antioxidant potentialof Hylocereuspolyrhizus peel extract using biochemical approach
Authors: Muksin Y D , Mahrus  , Bahri S 
Published: December 2021

AbstractRed dragon fruit orHylocereuspolyrhizusis one of the most popular fruits in Indonesia. Besides being consumed directly,H. Polyrhizusprocessed into various forms of processed food products such as jams, syrups, sweets, tea, and functional drinks. Unfortunately, massive quantities of solid waste, includingH. polyrhizuspeel produced every year, continues to increase from year to year. Their disposal led to severe environmental issues. Whereas,H. polyrhizuspeels are abundant in beneficial secondary metabolites compoundespecially flavonoid and phenolic. The presence of flavonoid and phenolic content provides many benefits in the development of natural medicines, especially as antioxidants. However, the research related to exploring antioxidant potentials ofH. polyrhizuspeel is still very limited. This study aimed to explore the phytochemical ofH. polyrhizuspeel and their role as a natural-antioxidant agent.H. polyrhizuspeels were extracted through a maceration method using 96% of ethanol as their solvent. A total phenolic essay is determined by the method of Folin-Ciocalteu reagent using gallic acid as a reference. AlCl3 reagent is used to analyse the flavonoid content by comparing with quercetin. Antioxidant activity was done by DPPH and ABTS free radical scavenging methods. The total phenolic and flavonoid content ofH. polyrhizuspeel extract (HPPE) at 107.35 ± 8.02 mg GAE/g and 108.82 ± 12.69 mg QE/g respectively. Furthermore, antioxidant activity of HPPE showed IC50 value at 136.20 ± 0.70 Lig/ml Lig/ml with DPPH methods and 390.70 ± 1.25 Lig/ml ug/ml with ABTS methods. Based on this recent study, HPPE has a moderate antioxidant activity by reducing free radicals in dose dependent manner.