bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioinformatics analysis revealing prognostic significance of TIMP2 gene in breast cancer
Authors: Chen Wen-Quan , Yang Su-Jin , Xu Wen-Xiu , Deng Fei , Wang Dan-Dan , Tang Jin-Hai 
Published: October 2021

Abstract
Tissue inhibitor of metalloproteinases 2 (TIMP2) is a member of the TIMP gene family. Accumulated evidence indicates that TIMP2 plays a significant role in various tumor processes including cell growth, apoptosis, invasion, and metastasis. However, the expression patterns and exact roles of TIMP2 had not been elucidated in breast cancer. In our research, we evaluated the expression and prognostic value of TIMP2 in breast cancer through analyzing various databases including Oncomine, bc-GenExMiner, PrognoScan, UCSC Xena, Kaplan–Meier Plotter, and PPI network. The results showed that TIMP2 was down-regulated in various breast cancer subtypes. Additionally, TIMP2 was significantly associated with age, estrogen receptor status, basal-like group, triple-negative breast cancer, PAM50 subtypes, and RSSPC subtypes. Also, the expression of TIMP2 was related to overall survival with different clinical characteristics. We analyzed the co-expressed genes with TIMP2 and interaction information with other proteins. These results disclosed that TIMP2 might serve as a potential target and prognostic biomarker in breast cancer. However, additional research is required to demonstrate our findings and motivate the clinical importance of TIMP2 in breast cancer.
Radiological and clinical findings of idiopathic myointimal hyperplasia of mesenteric veins
Authors: Xie Huanhuan , Xu Xiaopei 
Published: October 2021

Abstract

Introduction:
Idiopathic myointimal hyperplasia of mesenteric veins (IMHMV) is an uncommon cause of ischemic bowel disease resulting from the proliferation of smooth muscles in the venous intima. Delayed diagnosis could only be made following the surgical resection due to lack of imaging data, which may lead to bowel severe bleeding, perforation, necrosis, infection, or shock. In previous reports, few cases have provided the detailed pre-operative radiological characteristics of IMHMV. Herein, we are the first to provide the complete clinical course and comprehensive pre-operative radiological data of a 21-year-old female diagnosed with IMHMV.

Patient concerns:
A 21-year-old female was admitted to our hospital with bloody diarrhea and abdominal pain. Physical examination revealed tenderness localized to the left lower abdomen. The patient had no prior history of similar symptoms. A computed tomography scan was performed and showed diffuse wall thickening from the rectum to sigmoid colon with poor mural enhancement, multiple ulcers, fat stranding, and free fluid. The arterial phase images demonstrated many tortuous pericolic arteries and submucosal pseudoaneurysm.

Intervention:
Conservative treatment including empirical antibiotics, Mesalazine, and methylprednisolone sodium succinate were administrated to relief the symptoms. However, the diarrhea and abdominal pain worsened. An emergency surgery was arranged and total proctocolectomy with ileal pouchanal anastomosis with ileostomy was performed.

Diagnosis:
Macroscopic and histopathological examinations of the excised specimen showed ischemic colitis. Elastica van Gieson staining revealed extensive myointimal hyperplasia and confirmed the diagnosis of IMHMV.

Outcomes:
During the 2-year follow-up period, no additional medical management was needed. The patient was well and surveillance colonoscopy showed normal colon and anastomosis.

Conclusion:
Pre-operative computed tomography with imaging features including pronounced continuous concentric thickening colonic wall with poor enhancement and enlarged tortuous pericolic arteries could specifically facilitate the speedy diagnosis of IMHMV.
Association of elevated plasma inflammatory biomarker levels with age-related macular degeneration but not cataract in persons with AIDS
Authors: Jabs Douglas A. , Van Natta Mark L. , Schneider Michael F. , Pak Jeong Won , Trang Garrett , Jones Norman G. , Milush Jeffrey , Hunt Peter W. 
Published: October 2021

Objective:
To evaluate the relationship between plasma biomarkers of systemic inflammation and incident age-related macular degeneration (AMD) in persons with the AIDS.

Design:
Case–control study.

Methods:
Participants with incident intermediate-stage AMD (N = 26) in the Longitudinal Study of the Ocular Complications of AIDS (LSOCA) and controls (N = 60) without AMD. Cryopreserved baseline plasma specimens were assayed for biomarkers of inflammation, including high-sensitivity C-reactive protein (CRP), interleukin (IL)-6, interferon-γ inducible protein (IP)-10, soluble CD14 (sCD14), soluble CD163 (sCD163), and intestinal fatty acid-binding protein (I-FABP).

Results:
After adjustment for age, sex, and race/ethnicity, baseline mean ± standard deviation (SD) log10(mg/ml) plasma levels of CRP (0.52 ± 0.60 vs. 0.20 ± 0.43; P = 0.01) and mean ± SD log10(pg/ml) plasma levels of sCD14 (6.31 ± 0.11 vs. 6.23 ± 0.14; P = 0.008) were significantly higher among cases (incident AMD) than among controls (no AMD). There was a suggestion that mean ± SD baseline log10(pg/ml) plasma IL-6 levels (0.24 ± 0.33 vs. 0.11 ± 0.29; P = 0.10) might be higher among cases than controls. In a separate analysis of 548 participants in LSOCA, elevated baseline levels of plasma inflammatory biomarkers were associated with a greater risk of mortality but not with an increased risk of incident cataract.

Conclusion:
These data suggest that systemic inflammatory biomarkers are associated with incident AMD but not incident cataract in persons with AIDS, and that systemic inflammation may play a role in the pathogenesis of AMD.
Distinct effects of treatment with two different interferon-alpha subtypes on HIV-1-associated T-cell activation and dysfunction in humanized mice
Authors: Rout Saurav S. , Di Yunyun , Dittmer Ulf , Sutter Kathrin , Lavender Kerry J. 
Published: October 2021

Objective:
Interferon-alpha (IFN-α) has been associated with excessive immune activation and dysfunction during HIV-1 infection. However, evidence suggests specific IFN-α subtypes may be beneficial rather than detrimental. This study compared the effects of treatment with two different IFN-α subtypes on indicators of T-cell activation and dysfunction during HIV-1 infection.

Design:
Humanized mice were infected with HIV-1 for 5 weeks and then treated with two different IFN-α subtypes for an additional 3 weeks. Splenic T cells were assessed both immediately posttreatment and again 6 weeks after treatment cessation.

Methods:
HIV-1 infected triple-knockout bone marrow-liver-thymus mice received daily intraperitoneal injections of either IFN-α14 or the clinically approved subtype, IFN-α2. T cells were analysed directly ex vivo for indicators of activation and dysfunction or stimulated to determine their proliferative capacity and ability to produce functional mediators.

Results:
Unlike IFN-α2, IFN-α14 treatment reduced viremia and resulted in less activated CD4+ T cells and a lower naïve to effector CD8+ T-cell ratio. Despite exhibiting a reduced proliferative response, the frequency of CD8+ T cells from IFN-α14 treated mice that produced functional mediators and expressed markers of dysfunction was more similar to healthy controls than untreated and IFN-α2 treated mice. Frequencies of exhaustion marker expression remained higher in untreated and IFN-α2 treated mice 6 weeks posttreatment despite similar viral loads between groups at this timepoint.

Conclusions:
Treatment with different IFN-α subtypes had distinctive effects on T cells during HIV-1 infection. IFN-α14 was associated with fewer indicators of T-cell dysfunction whereas IFN-α2 treatment had little impact.
Robotic vs. Open Approach for Older Adults Undergoing Retromuscular Ventral Hernia Repair
Authors: Collins Courtney E. , Renshaw Savannah , Huang Li-Ching , Phillips Sharon , Gure Tanya R. , Poulose Benjamin 
Published: October 2021

Objective:
To describe 30-day outcomes including post-operative complications, readmissions, and quality of life score changes for older adults undergoing elective ventral hernia repair with retromuscular mesh placement and to compare rates of these outcomes for individuals undergoing robotic versus open approaches.

Summary of Background Data:
Over one third of patients presenting for elective ventral hernia repair are over the age of 65 and many have complex surgical histories that warrant intricate hernia repairs. Robotic ventral hernia repairs have gained increasing popularity in the US and in some studies have demonstrated decreased rates of postoperative complications, and less pain resulting in shorter hospital stays. However, the robotic approach has several downsides including prolonged operative times as well as the use of pneumo-peritoneum which may be risky in older patients.

Methods:
We performed a retrospective review of prospectively collected data in a national hernia specific registry (the Abdominal Core Health Quality Collaborative) and identified patients over the age of 65 undergoing either an open or robotic retromuscular ventral hernia repair. After propensity score matching adjusting for demographic, clinical, and hernia related factors, logistic regression was used to compare 30-day complications, readmission, and quality of life (QoL) scores as captured by the HerQLes scale for patients undergoing each approach.

Results:
Of 2128 patients who met inclusion criteria, 1695 (79.7%) underwent open ventral hernia repair while 433 (20.3%) underwent robotic repair. After propensity score matching, there were 350 robotic cases and 759 open cases for analysis. Patients undergoing robotic repairs demonstrated significantly shorter length of stays (1 vs 4 days, P < 0.01) and had equivalent odds of both 30-day post-operative complications (odds ratio [OR] 1.15 95% confidence interval 0.92–1.44) and readmission (OR 1.09 95% confidence interval 0.74–1.6) compared to the open approach. QoL scores were similar between groups at 30 days but were slightly better for robotic patients at 1 year (92 vs 84 P < 0.01).

Conclusions:
Robotic ventral hernia repair is an option for appropriately selected older patients undergoing retromuscular ventral hernia repair, demonstrating shorter hospital stays and equivalent rates of complications and readmissions in the post-operative period. However, more data is needed regarding QoL outcomes and long-term function, especially as it relates to recurrence rates, between the two approaches.
Gait Alterations in Knee Osteoarthritis
Authors: Pollet Joel , Buraschi Riccardo 
Published: October 2021

Objective:
People with knee osteoarthritis suffer from many different symptoms and signs, including gait deviations. Studying in deep these alterations through precise instruments like optoelectronic systems allows clinicians to identify alterations on the different body planes during gait.

Methods:
This study highlights the different alterations found by literature, analyzing them according to the single gait phase.

Results:
The spatiotemporal parameters are among the most altered parameters; with stride length and speed reduction, on the kinetic and kinematic level, the knee range of motion is reduced while the moments affecting the knee, hip, and ankle joint are altered in the different phases of stance.

Conclusions:
Preliminary studies have been developed on the possible quantification of these alterations through scoring systems like the Gait Deviation Index. Further studies should use this scoring system also to solve the issue between the possible correlation of pain and gait deviation that literature is still trying to solve.
Application of a Multicomponent Exercise Program on Functional Capacity in Hip Fractures in Hospitalized Older Adults
Authors: Cuenca Zaldívar Juan Nicolas , Acevedo Alvaro Monroy , Caballero Nahúm María , Fernández-Carnero Josué 
Published: October 2021

Background:
To evaluate the effects of multicomponent exercise program (Vivifrail) in patients with hip fracture after surgery over the gait pattern, balance, and muscle strength in the lower body.

Methods:
Thirty-seven patients operated of hip fracture were enrolled between 2017 and 2018.

Results:
There were significant improvements (P < .05) in the Short Physical Performance Battery, Tinetti balance, and gait scales, improving the independence measured with the Barthel Index and reducing the risk of falls.

Conclusions:
The multicomponent exercise improved with minimally obnoxious changes and the ability to balance and walk in older people who have undergone surgery for hip fracture, and also the number of responders who meet the minimally detectable changes is 70.27%.
Effect of a Proprioceptive Exercise Program on Force Sense for Carpometacarpal Joint Osteoarthritis
Authors: Cantero-Tellez Raquel , García-Orza Santiago , Sánchez Romero Eleuterio A. , Battaglino Andrea , Cruz-Gambero Leire , Cuadros-Romero Miguel 
Published: October 2021

Background:
Force sense is described as the ability to reproduce a desired level of strength. An adequate sensation of the muscular thumb effort allows us to be able to carry out activities of daily life.

Objective:
The primary objective of the present study was to evaluate the impact of a proprioceptive exercise program on the force sense for carpometacarpal joint.

Methods:
A total of 17 elderly women with a diagnosis of carpometacarpal joint osteoarthritis in their dominant hand participated in the study. Mean pinch force errors were measured at basal, 4, and 12 weeks of treatment.

Results:
Statistically significant differences in force sense testing scores after the proprioceptive exercise program were observed.

Conclusion:
The proprioceptive exercise program could improve precision on force sense of the thumb in patients with carpometacarpal joint osteoarthritis.
Collateral positives of COVID-19 for culturally and linguistically diverse communities in Western Sydney, Australia
Authors: Cornell S , Ayre J , Mac O , Kapoor R , Pickles K , Batcup C , Dolan H , Bonner C , Cvejic E , Mouwad D , Zachariah D , Turalic U , Santalucia Y , Chen T , Vasic G , McCaffery K , Muscat DM 
Published: October 2021

AbstractIssues addressedTo investigate whether culturally and linguistically diverse communities in Western Sydney have experienced any positive effects during the COVID-19 pandemic, and if so, what these were.MethodsA cross–sectional survey with ten language groups was conducted from 21stMarch to 9thJuly 2021 in Sydney, Australia. Participants were recruited through bilingual multicultural health staff and health care interpreter service staff and answered a question, ‘In your life, have you experienced any positive effects from the COVID-19 pandemic?’ Differences were explored by demographic variables. Free–text responses were thematically coded using the Content Analysis method.Results707 people completed the survey, aged 18 to >70, 49% males and 51% females. Only 161 (23%) of those surveyed reported any positive impacts. There were significant differences in the proportion of those who reported positives based on age (p=0.004), gender (p=0.013), language (p=0.003), health literacy (p=0.014), English language proficiency (p=0.003), education (p=<0.001) and whether participants had children less than 18 years at home (p=0.001). Reporting of positive impacts ranged from 12% for people aged seventy years or older to 30% for the 30–49-year age group. Reporting of positive impacts for different language groups ranged from 9% to 42%. 18% of men reported positive impacts compared to 27% of women, and 18% of people with inadequate health literacy reported positive impacts compared to 26% with adequate health literacy. Content Analysis of open-ended responses showed that, of those that did report positives, the top themes were ‘Family time’ (44%), ‘Improved self-care’ (31%) and, ‘Greater connection with others’ (17%).ConclusionsFrom 21st March to July 9th, 2021, few surveyed participants reported finding any positives because of the COVID–19 pandemic. This finding is in stark contrast to related research in Australia in a population dominated by adults with English as their first language, carried out in June 2020, in which many more people experienced positives.So whatThe needs of people from culturally and linguistically diverse backgrounds must inform future responses to community crises to facilitate an equitable effect of any collateral positives that may arise.
Single-particle tracking of dynein identifies PP2A B55/SUR-6 as a cell cycle regulator of cortical force generation
Authors: Edwards Alan , Linehan John B. , Boudreau Vincent , Maddox Paul S. 
Published: October 2021

AbstractConvergence and positioning of the pronuclei and mitotic spindle of many zygotes aids efficient division and is essential for early embryonic patterning. In the C. elegans zygote, interactions between microtubules and cortically anchored dynein are key to early development. However, how cortical microtubule pulling forces are controlled through the cell cycle is less well understood. We used single-molecule imaging and a windowed mean squared displacement analysis to uncover the behavior of dynein during cortical force generation, and provide a regulatory role for protein phosphatase PP2A-B55/SUR6 via NuMA-like protein LIN-5 in this process. Previous findings and our results suggest that PP2A regulates cortical microtubule pulling forces by increasing dynein binding and unbinding to the cortical force generation complex. Our data also suggests that cortical occupancy of dynein is abrogated to vary force generation. Our approach will be broadly applicable to classify the force generation behavior of single molecules in living organisms.
The role of competitive environment and strategy in the supply chain's agility, adaptability and alignment capabilities
Authors: Garrido-Vega Pedro , Sacristán-Díaz Macarena , Moyano-Fuentes José , Alfalla-Luque Rafaela 
Published: October 2021

PurposeThis paper analyses the way that the industry's competitive environment and the company's strategy influence the implementation of the supply chain's (SC’s) triple-A capabilities (agility, adaptability and alignment). Two competitive environment variables are analysed: competitive intensity of the industry and complexity of the SC. Two opposing competitive strategies are also considered: cost and differentiation.Design/methodology/approachThe hypotheses have been tested using data gathered via a questionnaire given to 277 Spanish manufacturing companies, and structural equation modelling has been used for the analysis.FindingsThe results show that competitive intensity is the most influential factor followed by business strategy. SC complexity does not seem to affect agility. Moreover, although the competitive environment variables affect the business strategy, the latter has no mediating effects between the competitive environment and SC agility, adaptability and alignment capabilities.Originality/valueThis study presents new insights into the environmental and strategic drivers linked to the implementation of SC agility, adaptability and alignment capabilities and offers guidelines to managers involved in SC management.
The positive and negative impacts of social and personal self-categorizations on sport fans' experience
Authors: Toder Alon Anat , Shuv-Ami Avichai , Bareket-Bojmel Liad 
Published: October 2021

PurposeThe current study postulated that fans' social identities (derived from the team sport clubs of which they perceive themselves to be members) coexist with their personal identities (derived from views of themselves as unique, individual sport fans). The study examined the relationship between identity salience and both positive and negative aspects of fans' attitudes, emotions and behaviours.Design/methodology/approachSeven hundred and twelve (712) Israeli professional football fans participated in this study. The study employed a survey drawn from an Internet panel with more than fifty thousand members.FindingsUtilizing structural equation modelling (SEM), the authors demonstrated that while social identity salience is related to positive aspects of being a sport fan (love of a favourite team and loyalty), it is also related to negative aspects of being a sport fan (hatred and perceptions of the appropriateness of fan aggression). Personal identity salience was found to be related to the decrease in negative outcomes of being a fan (hatred and perceptions of the appropriateness of fan aggression).Research limitations/implicationsMarketers and sport organizations will benefit from stimulating sport fans' personal identity salience to mitigate possible negative consequences of team affiliation.Originality/valueThe current study expands upon past sport management studies by demonstrating the existence of relationships between sport fans' identity salience and their emotions, attitudes and behaviours. The identity salience of fans is relevant from both academic and applicative perspectives.
The economics of the Manila Galleon
Authors: Mejia Javier , Mejia Javier 
Published: October 2021

PurposeThis paper aims to offer a unified economic interpretation of the existing evidence on the Manila Galleon. It intends to be an introduction to the Manila Galleon for economists curious about long-term patterns in global trade, but who are not experts on economic history.Design/methodology/approachThe paper jointly presents quantitative and qualitative data to analyze in a critical way the existing work on the Manila Galleon. It proposes a conceptual model from the world-systems approach to reflect on the impact of this trade route. Evidence from two case studies, New Granada and Korea, accompany the model.FindingsThe paper finds that the Manila Galleon was only possible because of the temporary coincidence of a quite singular set of international circumstances and favorable local market conditions. The paper also finds that, despite its large effects on the global integration of silver markets, the Manila Galleon was a profoundly asymmetric activity that brought minor consequences to most of the world.Research limitations/implicationsThis paper shows the importance of additional studies providing systematic quantitative evidence on the Manila Galleon. The long tradition of an archival collection developed by historians offers a huge potential to this line of research. In addition, studies in regions different from Mexico, the Philippines, Spain and China would contribute to a better understanding of the Manila Galleon’s global consequences.Practical implicationsThis paper provides a series of reflections useful to think about the future challenges of global trade. These challenges require understanding the transformations that will come from profound technological change, massive reconfigurations of the geopolitical order and transitions in the long-term cycles of commodities. Because of their rare occurrence, these are forces hardly visible in recent history, making it necessary for the existence of long-term points of reference such as the Manila Galleon.Originality/valueThis paper brings together widespread evidence on the Manila Galleon and provides a unified interpretation of it. This opens the door for audiences who are not experts on the economic history of the period to discuss the topic, allowing them to reflect on its lessons for the modern world.