bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient satisfaction and safety in the administration of sedation by nursing staff in the digestive endoscopy service: a cross-sectional study
Authors: Hidalgo-Cabanillas Miriam , Laredo-Aguilera José Alberto , Cobo-Cuenca Ana Isabel , Molina-Madueño Rosa María , Santacruz-Salas Esmeralda , Rodriguez-Muñoz Pedro Manuel , Carmona-Torres Juan Manuel 
Published: December 2024

Abstract
Background
The satisfaction of patients with sedation by nursing staff is an issue of interest for the quality of health care, influencing the recovery and well-being of patients as well as their confidence in and adherence to treatment. One of the most frequently performed diagnostic and therapeutic tests requiring sedation are digestive endoscopies, so it would be interesting to study satisfaction in these services.

Aim
To determine the level of patient satisfaction and safety with sedation via digestive endoscopies by nurses.

Methods
This was a cross-sectional study in the Digestive Endoscopy Service at the University Hospital of Toledo, Spain. The sample consisted of 660 adult patients from the digestive endoscopy service who were sedated between June–September 2023. The degree of satisfaction with the service was measured by the questionnaire: Survey of patient satisfaction with the digestive endoscopy service. The study was approved by the ethics committee.

Results
Patients who reported satisfaction with the treatment were very satisfied with the sedation provided by the nurses. The most valued item was the attention of the nursing professionals. The least valued items were the waiting time for the appointment and the time spent in the waiting room on the same day. The incidence of complications recorded during the test were minimal (2% of all patients).

Conclusions
Most patients are satisfied with the sedation administered by nurses via digestive endoscopies, and complications were rare, supporting the efficacy and acceptance of this practice. Clinical practice guidelines and consensus documents in Spain guarantee that nurses have autonomy to administer sedation in digestive endoscopy services, but there is a lack of national regulations to support this technique. The current consensus in Spain is that specific training is necessary for such nurses.
Compensating elastic faults in a torque-assisted knee exoskeleton: functional evaluation and user perception study
Authors: Velasco-Guillen Rodrigo J. , Bliek Adna , Font-Llagunes Josep M. , Vanderborght Bram , Beckerle Philipp 
Published: December 2024

AbstractWearable robots are often powered by elastic actuators, which can mimic the intrinsic compliance observed in human joints, contributing to safe and seamless interaction. However, due to their increased complexity, when compared to direct drives, elastic actuators are susceptible to faults, which pose significant challenges, potentially compromising user experience and safety during interaction. In this article, we developed a fault-tolerant control strategy for torque assistance in a knee exoskeleton and investigated user experience during a walking task while emulating faults. We implemented and evaluated the torque control scheme, based on impedance control, for a mechanically adjustable compliance actuator with nonlinear torque-deflection characteristics. Conducted functional evaluation experiments showed that the control strategy is capable of providing support during gait based on a torque profile. A user study was conducted to evaluate the impact of fault severity and compensation on the perception of support, stiffness, comfort, and trust while walking with the exoskeleton. Results from the user study revealed significant differences in participants’ responses when comparing support and stiffness levels without fault compensation. In contrast, no significant differences were found when faults were compensated, indicating that fault tolerance can be achieved in practice. Meanwhile, comfort and trust measurements do not seem to depend directly on torque support levels, pointing to other influencing factors that could be considered in future research.
FAIR Data Cube, a FAIR data infrastructure for integrated multi-omics data analysis
Authors: Liao Xiaofeng , Ederveen Thomas H.A. , Niehues Anna , de Visser Casper , Huang Junda , Badmus Firdaws , Doornbos Cenna , Orlova Yuliia , Kulkarni Purva , van der Velde K. Joeri , Swertz Morris A. , Brandt Martin , van Gool Alain J. , ’t Hoen Peter A. C. 
Published: December 2024

Abstract
Motivation
We are witnessing an enormous growth in the amount of molecular profiling (-omics) data. The integration of multi-omics data is challenging. Moreover, human multi-omics data may be privacy-sensitive and can be misused to de-anonymize and (re-)identify individuals. Hence, most biomedical data is kept in secure and protected silos. Therefore, it remains a challenge to re-use these data without infringing the privacy of the individuals from which the data were derived. Federated analysis of Findable, Accessible, Interoperable, and Reusable (FAIR) data is a privacy-preserving solution to make optimal use of these multi-omics data and transform them into actionable knowledge.

Results
The Netherlands X-omics Initiative is a National Roadmap Large-Scale Research Infrastructure aiming for efficient integration of data generated within X-omics and external datasets. To facilitate this, we developed the FAIR Data Cube (FDCube), which adopts and applies the FAIR principles and helps researchers to create FAIR data and metadata, to facilitate re-use of their data, and to make their data analysis workflows transparent, and in the meantime ensure data security and privacy.
BACE1 inhibitory potential: screening of medicinal plants collected from Nepal high altitude regions
Authors: Pandey Bishnu Prasad , Oh Jong Min , Shin Woong-Hee , Subedi Abhimat , Dahal Ankita , Bhattarai Sumit , Kim Hoon 
Published: December 2024

AbstractFifty-four plant extracts from thirty-two medicinal plants collected in Nepal were evaluated for their inhibitory potential against the enzyme beta-secretase-1 (BACE1), to identify potential therapeutic agents for Alzheimer’s disease (AD). Of the studied extracts, rhizome extract of Rheum australe D. Don showed the highest inhibitory potential, with an IC50 value of 0.872 ± 0.006 µg/mL. After BACE1 inhibitory activity check using 9 fractions collected from Prep-HPLC, further profiling of the metabolites of the best fraction 7 was performed using high-resolution mass spectrometry (HRMS). Results revealed the presence of diverse secondary metabolites, including aloe-emodin-8-O-β-D-glucoside, rhein-8-O-glucoside, piceatannol-3’-O-β-D-glucoside, emodin-8-glucoside, physcion 8-O-β-D-glucoside, desoxyrhaponticin, chrysophanol-8-O-glucoside, rhapontigenin, rhein, desoxyrhapontigenin, piceatannol, chrysophanol, physcion, and aloe-emodin. In-silico docking simulations were performed to identify potent compounds with high binding efficiencies to BACE1. Compound picetannol-3’-O-β-D-glucoside showed the best binding energy (-53.494 kcal/mol) and inhibitory potential with an IC50 value of 1.270 ± 0.130 µM for BACE1. These results suggested that the R. australe D. Don extract is a promising agent for the treatment of AD.
Knockdown of IGF2BP2 overcomes cisplatin-resistance in lung cancer through downregulating Spon2 gene
Authors: Zhang Shilei , Dou Ting , Li Hong , Yu Hongfang , Zhang Wei , Sun Liping , Yang Jingwen , Wang Zhenfei , Yang Hao 
Published: December 2024

Abstract
Background
Cisplatin (DDP) resistance has long posed a challenge in the clinical treatment of lung cancer (LC). Insulin-like growth factor 2 binding protein 2 (IGF2BP2) has been identified as an oncogenic factor in LC, whereas its specific role in DDP resistance in LC remains unclear.

Results
In this study, we investigated the role of IGF2BP2 on DDP resistance in DDP-resistant A549 cells (A549/DDP) in vitro and in a DDP-resistant lung tumor-bearing mouse model in vivo. Additionally, methylated RNA immunoprecipitation sequencing (MeRIP-seq) was conducted to identify the potential mRNAs regulated by IGF2BP2, an N6-methyladenosine (m6A) regulator, in the tumor tissues of mice. Compared to normal tissues, IGF2BP2 levels were increased in LC tissues and in relapsed/resistant LC tissues. Most importantly, IGF2BP2 levels were significantly higher in relapsed/resistant LC tissues than in LC tissues. Significantly, knockdown of IGF2BP2 or DDP treatment inhibited A549 cell viability, migration, and cell cycle progression. Consistently, DDP treatment suppressed the viability and migration and triggered cell cycle arrest in A549/DDP cells in vitro, as well as reduced tumor volume and weight of A549/DDP tumor-bearing mice; meanwhile, the combination of DDP and IGF2BP2 siRNA further significantly inhibited A549/DDP cell growth in vitro and in vivo compared to DDP treatment alone. Furthermore, MeRIP-seq data showed that IGF2BP2 downregulation remarkably elevated m6A levels of spondin 2 (Spon2) and reduced mRNA levels of Spon2 in tumor tissues from A549 tumor-bearing mice. Meanwhile, the combination of DDP and IGF2BP2 siRNA notably reduced Spon2 levels, as well as inhibited the viability and induced apoptosis in A549/DDP cells; however, these effects were reversed by Spon2 overexpression.

Conclusion
Collectively, downregulation of IGF2BP2 could overcome DDP resistance in LC through declining the Spon2 gene expression in an m6A-dependent manner. These results may provide a new strategy for overcoming DDP resistance in LC.
Advancements in Early Alzheimer’s Treatment: Narrative Review about Lecanemab (Leqembi ®)
Authors: Muciek Adrianna , Mocarska Martyna , Orłowska Anna , Strakowska Katarzyna , Opalska Laura , Maryńczak Anna , Mencel Jan , Nitschke Nicole 
Published: December 2024

Alzheimer's disease represents one of the most significant challenges in the field of neurology, affecting millions of individuals worldwide. In pursuing efficacious treatments, lecanemab has emerged as a promising therapeutic option. This pioneering monoclonal antibody targets and reduces amyloid-beta plaques in the brain, a defining feature of Alzheimer's disease. By addressing one of the fundamental causes of the disease, lecanemab represents a novel approach to slowing its progression.
On 14th November 2024, the Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion, recommending granting marketing authorisation for Leqembi® (whose active substance is lecanemab). This recommendation is specifically directed towards patients with early-onset Alzheimer's disease who are non-carriers or heterozygotes for the apolipoprotein E ε4 (ApoE ε4) allele, thereby underscoring the drug's efficacy tailored to specific genetic profiles (Committee for Medicinal Products for Human Use, 2024).
The CHMP's approval is a testament to the extensive research and clinical trials that have demonstrated the efficacy and safety of Leqembi® (Lecanemab). This narrative review aims to provide a comprehensive examination of these aspects and offer a detailed understanding of the potential impact of this treatment on the management of early Alzheimer's disease.
Examining the relationship between levels of susceptibility to the teamwork of people working in disasters and their trust in their colleagues
Authors: Bilen Gül 
Published: December 2024

This study examines the relationship between the level of susceptibility to the teamwork of people working in disasters and their trust in their colleagues. The research sample comprises 218 AFAD volunteers in the Aksaray Provincial Disaster and Emergency Directorate. Online surveys were applied to the participants. According to the findings obtained from the research, the following results were reached: It was seen that the participants' level of susceptibility to teamwork was at a medium level. It was determined that the dimensions of education and guidance and problem diagnosis and analysis, which are sub-dimensions of the susceptibility to teamwork variable, were at the highest level among the dimensions. It was concluded that the high internal motivation dimension was at the lowest level. It was determined that the participants' level of trust in their colleagues was quite high. In addition, the susceptibility to teamwork of people involved in disasters significantly impacted trust in colleagues. Significant relationships were found between teamwork disposition and sub-dimensions such as trust, problem diagnosis and analysis, responsibility (initiative, willingness), training and guidance, cooperation and teamwork and leadership, persuasion, determination and trust in colleagues. No significant relationship was found between a high internal motivation dimension and colleague trust, a sub-dimension of teamwork susceptibility. Within the scope of this research, studies in the literature related to the concepts of teamwork susceptibility and trust in colleagues were first examined. In light of the information obtained, it was aimed to contribute to the literature by creating applied research.
Akibat Hukum Kepemilikan Sertifikat Hak Milik Atas Tanah Bagi Para Pihak Berdasarkan Perjanjian Nominee
Authors: Faebriyanti Mawar , Hidayat Asep Syarifuddin 
Published: December 2024

The main problem in this study is the many nominee agreement practices in Indonesia, especially in Bali, as in the case of Decision Number 137/Pdt.G/2021/PN. Gin. The purpose of this study is to examine the legal consequences of ownership of land title certificates for parties based on nominee agreements and then the researcher explains the Responsibility of Beneficial Owners who own land and buildings in Indonesia based on nominee agreements against taxes due to the transfer of land and building rights. This research uses a type of qualitative research that is descriptive analysis using a normative-juridical approach. This research was conducted using library research, by examining the approach of theories, concepts, reviewing the statute approach related to this law research and the case approach, namely the implementation of law in handling nominee agreement cases. The results showed that there were differences of opinion between judges in deciding cases related to nominee agreements, this was because there was no legal certainty regarding the rules governing nominee agreements. Furthermore, the legal consequences of ownership of title certificates over land do not only result in the parties, namely the land falls to the state and the agreement made is null and void. However, it also has repercussions for notaries and state losses, which are mainly related to taxes.

Permasalahan utama dalam penelitian ini adalah banyaknya praktik perjanjian nominee di Indonesia terutama di Bali seperti dalam kasus pada Putusan Nomor 137/Pdt.G/2021/PN.Gin. Adapun tujuan dari penelitian ini untuk mengkaji akibat hukum kepemilikan sertifikat hak milik atas tanah bagi para pihak berdasarkan perjanjian nominee dan selanjutnya peneliti menjelaskan Tanggung Jawab Beneficial Owner yang mempunyai tanah dan bangunan di Indonesia berdasarkan perjanjian nominee terhadap pajak akibat adanya pengalihan hak atas tanah dan bangunan. Penelitian ini menggunakan jenis penelitian kualitatif yang bersifat deskriptif analisis dengan menggunakan pendeketan normatif-yuridis. Penelitian ini dilakukan dengan menggunakan penelitian kepustakaan (library research), dengan menelaah pendekatan teori-teori, konsep-konsep, mengkaji peraturan perundang-undangan (statute approach) yang bersangkutan dengan penelitian ini hukum ini dan pendekatan kasus (case approach), yakni implementasi hukum dalam menangani kasus perjanjian nominee. Hasil penelitian menunjukan bahwa terdapat perbedaan pendapat antara hakim dalam memutuskan perkara terkait perjanjian nominee, hal ini disebabkan belum ada kepastian hukum mengenai aturan yang mengatur mengenai perjanjian nominee. Selanjutnya, akibat hukum dari kepemilikan sertifikat hak milik atas tanah tidak hanya berakibat bagi para pihak saja yakni tanahnya jatuh kepada negara dan perjanjian yang dibuat batal demi hukum. Tetapi, juga berakibat bagi Notaris dan kerugian negara terutama terkait dengan pajak.
FULL ARCH TREATMENT OF ATROPHIC EDENTULOUS MANDIBLE USING SHORT IMPLANTS WITH IMMEDIATE LOADING: CASE REPORT
Authors: Arroyo Esteban , Dias Mary Stella , Castro Andrade Santos Thales de , Miranda Deliberador Tatiana , Marques Padovan Luis Eduardo 
Published: December 2024

ABSTRACT
Full-arch implant rehabilitation in extremely atrophic edentulous mandibles is still challenging due to the high risk of fracture and the limited bone availability. The approach proposes using short implants with immediate loading for final prostheses as a treatment option, which offers shorter treatment times and fewer invasive procedures. A 66-year-old female patient with an edentulous mandible and severe alveolar bone resorption was treated with four short implants in the interforaminal area. The final hybrid metal-plastic full-arch lower prosthesis was delivered three days after the surgery, and the patient was instructed on cleaning methods and requested to maintain a soft diet for the first two postoperative months. After six months of follow-up, the patient experienced no problems; the prosthesis underwent a mechanical examination, each multiunit abutment's peri-implant tissue was assessed, and implants presented no mobility, fibrointegration, or signs of failure. X-ray images demonstrated stable bone levels around implants. Also, it was observed that the integrity of the entire jaw was preserved, and no signs of fracture were observed.
Artificial Intelligence in Academic Libraries: Foreign and Ukrainian Experience
Authors: SHEMAIEVA H. V. , KOSTYRKO T. M. , PRILUTSKA A. E. 
Published: December 2024

The objective is to determine the direction of implementing artificial intelligence (AI) in the activities of foreign and domestic academic libraries. Methods. The research is based on a combination of the method of analyzing the content of publications with the methods of systematization, generalization, surveying employees of academic libraries in Ukraine, and the method of comparative analysis. Results. It was found that the general directions for practical application of AI technologies in academic libraries of foreign and Ukrainian countries are: training, reference work, intelligent user service, and collection management. The main direction of the ChatGPT application is: to study this tool, and its application in reference and advertising activities. It was established that in libraries of foreign universities, the following are being initiated: the creation of intellectual spaces (USA); the use of robotics (Canada, China); and the formation of a smart library (USA, China). Conclusions. The importance of implementing AI technologies in the activities of academic libraries, which create new opportunities for scientific research and education, is confirmed. At the same time, the research confirms the insufficient level of AI implementation by university libraries to provide innovative alternative services. It is urgent to develop a strategy for the university library regarding implementing AI technologies and developing employees' relevant competencies.
Problems and Prospects of Information Interoperability of Academic Libraries in Central Asia
Authors: LAPO P. M. , RAKHMATULLAEV M. A. 
Published: December 2024

Objective. The article is devoted to the analysis of the current state and prospects of information interoperability between academic libraries in Central Asia (CA). Methods. Publications on the topic of information and library interoperability, including in CA, have been studied, experience in the area has been analysed and summarized. Results. The authors proposed a comprehensive and systematic approach and methods to develop interoperability of academic libraries in CA. Conclusions. Summarizing the international experience of interlibrary cooperation at the regional level, it should be recognized that it is successful provided that there is a comprehensive approach to its provision, that is, the relevant bodies for planning, coordinating and monitoring information interoperability should be created and functioning, library personnel with relevant competencies should be trained and involved in the work, the relevant software and hardware and infrastructure should be available.
COMPLETELY REACHABLE ALMOST GROUP AUTOMATA
Authors: Casas Torres David Fernando 
Published: December 2024

We consider finite deterministic automata such that their alphabets consist of exactly one letter of defect 1 and a set of permutations of the state set. We study under which conditions such an automaton is completely reachable. We focus our attention on the case when the set of permutations generates a transitive imprimitive group.
ON WIDTHS OF SOME CLASSES OF ANALYTIC FUNCTIONS IN A CIRCLE
Authors: Shabozov Mirgand Sh. , Saidusainov Muqim S. 
Published: December 2024

We calculate exact values of some $n$-widths of the class \(W_{q}^{(r)}(\Phi),\) \(r\in\mathbb{Z}_{+},\) in the Banach spaces \(\mathscr{L}_{q,\gamma}\) and \(B_{q,\gamma},\) \(1\leq q\leq\infty,\) with a weight \(\gamma\). These classes consist of functions \(f\) analytic in the unit circle, their \(r\)th order derivatives \(f^{(r)}\) belong to the Hardy space \(H_{q},\) \(1\leq q\leq\infty,\) and the averaged moduli of smoothness of boundary values of \(f^{(r)}\) are bounded by a given majorant \(\Phi\) at the system of points \(\{\pi/(2k)\}_{k\in\mathbb{N}}\); more precisely,$$ \frac{k}{\pi-2}\int_{0}^{\pi/(2k)}\omega_{2}(f^{(r)},2t)_{H_{q,\rho}}dt\leq \Phi\left(\frac{\pi}{2k}\right) $$for all \(k\in\mathbb{N}\), \(k>r.\)
INTEGRAL ANALOGUE OF TURÁN-TYPE INEQUALITIES CONCERNING THE POLAR DERIVATIVE OF A POLYNOMIAL
Authors: Singh Mayanglambam Singhajit , Chanam Barchand 
Published: December 2024

If \(w(\zeta)\) is a polynomial of degree $n$ with all its zeros in \(|\zeta|\leq \Delta, \Delta\geq 1\) and any real \(\gamma\geq 1\), Aziz proved the integral inequality [1] $$ \left\lbrace\int_{0}^{2\pi}\left|1+\Delta^ne^{i\theta}\right|^{\gamma}d\theta\right\rbrace^{{1}/{\gamma}}\max_{|\zeta|=1}|w^{\prime}(\zeta)|\geq n\left\lbrace\int_{0}^{2\pi}\left|w\left(e^{i\theta}\right)\right|^{\gamma}d\theta\right\rbrace^{{1}/{\gamma}}.$$ In this article, we establish a refined extension of the above integral inequality by using the polar derivative instead of the ordinary derivative consisting of the leading coefficient and the constant term of the polynomial. Besides, our result also yields other intriguing inequalities as special cases.