bluuebunny/crossref_metadata_2025_split huggingface dataset:
KDM5B promotes self‐renewal of hepatocellular carcinoma cells through the microRNA‐448–mediated YTHDF3/ITGA6 axis
Authors: Guo Jun‐Cheng , Liu Zhuo , Yang Yi‐Jun , Guo Min , Zhang Jian‐Quan , Zheng Jin‐Fang 
Published: April 2021

AbstractHistone methylation plays important roles in mediating the onset and progression of various cancers, and lysine‐specific demethylase 5B (KDM5B), as a histone demethylase, is reported to be an oncogene in hepatocellular carcinoma (HCC). However, the mechanism underlying its tumorigenesis remains undefined. Hence, we explored the regulatory role of KDM5B in HCC cells, aiming to identify novel therapeutic targets for HCC. Gene Expression Omnibus database and StarBase were used to predict important regulatory pathways related to HCC. Then, the expression of KDM5B and microRNA‐448 (miR‐448) in HCC tissues was detected by RT‐qPCR and Western blot analysis. The correlation between KDM5B and miR‐448 expression was analysed by Pearson's correlation coefficient and ChIP experiments, and the targeting of YTH N6‐methyladenosine RNA binding protein 3 (YTHDF3) by miR‐448 was examined by luciferase assay. Additionally, the effect of KDM5B on the proliferation, migration, invasion and apoptosis as well as tumorigenicity of transfected cells was assessed using ectopic expression and depletion experiments. KDM5B was highly expressed in HCC cells and was inversely related to miR‐448 expression. KDM5B demethylated H3K4me3 on the miR‐448 promoter and thereby inhibited the expression of miR‐448, which in turn targeted YTHDF3 and integrin subunit alpha 6 (ITGA6) to promote the malignant phenotype of HCC. Moreover, KDM5B accelerated HCC progression in nude mice via the miR‐448/YTHDF3/ITGA6 axis. Our study uncovered that KDM5B regulates the YTHDF3/ITGA6 axis by inhibiting the expression of miR‐448 to promote the occurrence of HCC.
Adipose‐derived mesenchymal stem cells induced PAX8 promotes ovarian cancer cell growth by stabilizing TAZ protein
Authors: Chu Yijing , Zhu Chengzhan , Wang Qianqian , Liu Meixin , Wan Wei , Zhou Jun , Han Rendong , Yang Jing , Luo Wenqiang , Liu Chong , Zhou Huansheng , Li Min , Yu Fengsheng , Ye Yuanhua 
Published: April 2021

AbstractOur previous studies have shown that the Adipose‐derived mesenchymal stem cells (ADSCs) can regulate metastasis and development of ovarian cancer. However, its specific mechanism has yet to be fully revealed. In this study, an RNA‐seq approach was adopted to compare the differences in mRNA levels in ovarian cancer cells being given or not given ADSCs. The mRNA level of paired box 8 (PAX8) changed significantly and was confirmed as an important factor in tumour‐inducing effect of ADSCs. In comparison with the ovarian cancer cells cultured in the common growth medium, those cultured in the medium supplemented with ADSCs showed a significant increase of the PAX8 level. Moreover, the cancer cell growth could be restricted, even in the ADSC‐treated group (P < .05), by inhibiting PAX8. In addition, an overexpression of PAX8 could elevate the proliferation of ovarian cancer cells. Moreover, Co‐IP assays in ovarian cancer cells revealed that an interaction existed between endogenous PAX8 and TAZ. And the PAX8 levels regulated the degradation of TAZ. The bioluminescence images captured in vivo manifested that the proliferation and the PAX8 expression level in ovarian cancers increased in the ADMSC‐treated group, and the effect of ADSCs in promoting tumours was weakened through inhibiting PAX8. Our findings indicate that the PAX8 expression increment could contribute a role in promoting the ADSC‐induced ovarian cancer cell proliferation through TAZ stability regulation.
Online‐delivered parenting intervention for young children with disruptive behavior problems: a noninferiority trial focused on child and parent outcomes
Authors: Prinz Ronald J. , Metzler Carol W. , Sanders Matthew R. , Rusby Julie C. , Cai Chao 
Published: April 2021

BackgroundThis study evaluated whether an evidence‐based parenting intervention, when delivered online, could effectively address disruptive behavior problems in young children and yield outcomes comparable to in‐person delivery of the same intervention.MethodsFamilies (n = 334) of children (3–7 years; 63% White, 22% African American, 15% other races; 63% male) with disruptive behavior problems were randomized to online‐delivered intervention (ODI) or staff‐delivered intervention (SDI), resulting in baseline and demographic equivalence. Primary outcome measures for child disruptive behavior (independent observation, parent report) and secondary outcome measures of parenting and family impact were assessed at baseline, postintervention, and follow‐up. Conducted using intent‐to‐treat (ITT) as well as per‐protocol (PP) methods, noninferiority analyses, which drew on an HLM framework with repeat measures across three timepoints and on REML to provide unbiased estimates of model parameters, tested whether the outcome‐difference CI did not exceed the a priori noninferiority margin.ResultsFor ITT and PP analyses, the ODI was found to be noninferior to the SDI on the primary outcome: independently observed child disruptive behavior and parent‐reported child behavior problems. The pattern for secondary outcomes was more varied: (a) noninferiority for observed positive and aversive parenting; (b) noninferiority for observed quality of parent–child relationship at post but not follow‐up assessment; (c) noninferiority for parent‐reported inappropriate/inconsistent discipline for PP but not ITT analyses; and (d) noninferiority not confirmed for parenting daily hassles and adverse family quality of life, despite large effect sizes for the ODI (Cohen's d .75–1.07). Finally, ODI noninferiority was found for teacher‐reported child disruptive behavior.ConclusionsThe tested online‐delivered parenting intervention demonstrated clear noninferiority with the corresponding staff‐delivered parenting intervention on the primary outcome, child disruptive behavior problems, and reflected substantial though nonuniform noninferiority and meaningful effect sizes for secondary outcomes related to parenting and family. Future research will guide optimization of online interventions.
A vertical oligopoly in which entry increases every firm's profit
Authors: Nariu Tatsuhiko , Flath David , Okamura Makoto 
Published: April 2021

AbstractWe develop a model in which each of m manufacturers forms a differentiated final product by assembling n components that are provided by its own n independent suppliers. Each supplier produces a unique component and sells to only one of the manufacturers. The manufacturers engage in product‐differentiated Cournot competition. We show that if initially the number of manufacturers is sufficiently small, and if the number of components is large enough, then, as the number of manufacturers increases, every firm—including downstream manufacturers and their upstream component suppliers—earns more profit. Entry can increase every firm's profit. The package‐tour industry of Japan is an example of such an industry. Drip coffee supplied by competing convenience stores in Japan is another.
Preseptal cellulitis associated with cosmetic eyelash lifting procedure
Authors: Mangan Mehmet Serhat , Imamoglu Serhat 
Published: April 2021

AbstractBackgroundThe increased popularity of periocular cosmetic applications in recent years has resulted in the appearance of various complications. The cosmetic eyelash lifting is one of these new techniques and is gradually becoming more popular. There are no previous reports of any complications of this procedure in the literature.AimsIn this study, we present a clinical case of preseptal cellulitis following cosmetic eyelash lifting procedure.Patient/MethodsA 55‐year‐old woman presented with bilateral eyelid swelling and redness. The history revealed that she had undergone cosmetic eyelash lifting procedure 2 days ago. There was no ocular movement limitation or pain. The biomicroscopic examination revealed bilateral eyelid edema and hyperemia, conjunctival hyperemia, chemosis, and mucopurulent secretion. The diagnosis was preseptal cellulitis when the clinical examination was evaluated together with the results of the laboratory tests and radiological imaging.ResultsSystemic and topical antibiotics were started, and the signs recovered in the first week.ConclusionsCosmetic eyelash lifting can rarely be one of the causes of preseptal cellulitis. It is important to detect and treat any blepharitis or meibomitis before the procedure. Eyelid hygiene and the proper sterilization conditions during the procedure must also be ensured.
Association between subthreshold depression and self‐care behaviours in adults with type 2 diabetes: A cross‐sectional study
Authors: Shrestha Monika , Ng Ashley , Paudel Rajan , Gray Richard 
Published: April 2021

AbstractAims and objectivesThe aim of the study was to test the association between subthreshold depression and self‐care behaviours in adults with type 2 diabetes (T2D) attending a tertiary healthcare service.BackgroundSuboptimal adherence to self‐care behaviours is associated with poor glycaemic control. The estimated point prevalence of subthreshold depression in people with T2D is 17%. Two previous studies have examined the association between subthreshold depression and self‐care behaviours in T2D, reported observations were inconsistent.DesignA cross‐sectional observational study.MethodsWe surveyed adults with T2D attending a tertiary healthcare facility in Nepal. Self‐care behaviours and subthreshold depression were assessed using the Summary of Diabetes Self‐care Activities and the Patient Health Questionnaire‐9, respectively. We used linear and logistic regression to test the association of subthreshold depression with total and individual self‐care behaviours. Our reporting complies with STROBE reporting guideline for observational research.ResultsJust over a third (37%) of the participants had subthreshold depression. People with subthreshold depression had slightly lower total diabetes self‐care score compared to those with no depression. More than half of participants with subthreshold depression had suboptimal adherence to diet, physical activity and foot care. Subthreshold depression was associated with total self‐care score (B = −0.27, 95% CI: −0.54, −0.01). In addition, association between subthreshold depression and diet adherence was observed (AOR = 0.26, 95% CI: 0.15, 0.44).ConclusionsSubthreshold depression is associated with decreased adherence to self‐care behaviour in people with T2D. Identification and treatment of subthreshold depression in T2D may lead to better adherence to diabetes self‐care behaviours.Relevance to clinical practiceThe recognition and treatment of subthreshold depression warrants further investigation as a strategy to improve the adherence to self‐care behaviours.
Factors associated with diabetes distress among adolescents with type 1 diabetes
Authors: Luo Jiaxin , Wang Hongjuan , Li Xia , Zhou Zhiguang , Valimaki Maritta , Whittemore Robin , Grey Margaret , Guo Jia 
Published: April 2021

AbstractAimsTo describe the specific domains of diabetes distress and factors associated with these domains.BackgroundDiabetes distress is a common problem but not well recognised in adolescents by healthcare providers or adolescents themselves. There is insufficient evidence on how specific domains of diabetes distress exist in adolescents, making it challenging to select precise components to alleviate diabetes stress.DesignA quantitative, descriptive and cross‐sectional study.MethodsData were collected on socio‐demographic and clinical characteristics, diabetes distress, perceived stress, self‐efficacy and diabetes self‐management using established questionnaires. Multivariate linear regression was conducted to examine the associations between specific factors and four domains in diabetes distress. STROBE checklist was used as the guideline for this study.ResultsA total of 100 adolescents with type 1 diabetes aged 12 to 18 years participated in this study. Adolescents experienced the highest levels of distress in the regimen‐related distress [2.41 (SD =0.82)] and physician‐related distress [2.40 (SD =0.80)] domains. Older age, female gender, more diabetes problem‐solving and higher levels of perceived stress were associated with higher regimen‐related distress (β = 0.21 ~ 0.45, p < 0.05). Older age, female gender, a lower degree of endorsement of relevant diabetes‐related goals and higher levels of perceived stress were associated with higher physician‐related distress (β = −0.29 ~ 0.34, p < 0.05).ConclusionsDiabetes distress was reported more on regimen‐related and physician‐related domains among adolescents with type 1 diabetes in China, associating with older age, female, increased perceived stress and poor diabetes‐related problem‐solving.Relevance to clinical practiceNurses need to screen the specific domains of diabetes distress among adolescents with type 1 diabetes, especially for the older adolescents and girls. This study highlighted the importance of incorporating diabetes‐related problem‐solving support and stress management strategies into diabetes management for adolescents with type 1 diabetes, which could help relieve diabetes distress.
Clinical instruments for bedside functional assessment: Convergent validity among the AM‐PAC ‘6‐Clicks’ and BMAT
Authors: Lininger Monica Rae , Warren Meghan , Knecht Jeff , Verheijde Joseph , Tyler Brenda , Tompkins James 
Published: April 2021

AbstractAims and ObjectivesTo determine the level of convergent validity of the ‘6‐Clicks’ Basic Mobility and Daily Activity with the Bedside Mobility Assessment Tool (BMAT) in patients admitted to a tertiary care academic hospital.BackgroundAccurately measuring a patient's ability to mobilise during hospitalisation is necessary but can be challenging. Two instruments, the Activity Measure for Post‐Acute Care short‐form ‘6‐Clicks’ and the BMAT, are commonly used to determine patients’ mobility levels; however, these instruments have not been psychometrically evaluated together. Understanding the characteristics between these tools can support the process of shared decision making amongst healthcare providers.DesignRetrospective Cohort adhering to the STROBE statement.MethodsUsing 13,498 individual patient admissions from an electronic health record, the BMAT score measured closest in time to the ‘6‐Clicks’ Basic Mobility and Daily Activity evaluation was collected. Spearman rank correlations with 95% confidence intervals (CIs) were calculated to determine the level of convergent validity between the ‘6‐Clicks’ Basic Mobility and Daily Activity with the BMAT. Pairwise correlations were also calculated and stratified by admitting medical service.ResultsAll correlations for the ‘6‐Clicks’ Basic Mobility or Daily Activity summative scores and the BMAT mobility levels were statistically significant and moderately correlated. The weakest correlations were seen within the Orthopaedic admitting service group. Most correlations stratified by admitting service [CVD/Pulmonary, Medicine/Hospitalist, Other Surgery and Solid Organ Transplant] were moderate. The strongest correlations were seen within the Neuro/Stroke admitting service.ConclusionModerate levels of convergent validity exist between the ‘6‐Clicks’ and the BMAT in this sample. These findings demonstrate that the construct of patient mobility is not being assessed similarly between the two instruments.Relevance to Clinical PracticeThese findings suggest the continued use of both instruments to allow interdisciplinary assessment of patient mobility status during a hospital stay.
Children living with long‐term conditions: A meta‐aggregation of parental experiences of partnership nursing
Authors: Barratt Macey , Bail Kasia , Paterson Catherine 
Published: April 2021

AbstractAimTo explore how parents of children with long‐term conditions experience partnership in paediatric and neonatal nursing care and to identify existing partnership barriers and facilitators.BackgroundParent–nurse partnership is fundamental to paediatric and neonatal nursing. Partnership is characterised by five attributes: parental participation, negotiation, mutual trust and respect, shared roles and decision‐making, and communication. Little is known about the parental experiences of partnership nursing specific to children living with a long‐term condition.DesignA qualitative meta‐aggregation review following Joanna Briggs Institute meta‐aggregation approach.MethodsA comprehensive search was conducted in six electronic databases. Studies were assessed according to the inclusion and exclusion criteria. Qualitative findings with illustrative quotes from included studies were extracted and grouped into categories which informed the synthesised findings. This review has been reported according to the PRISMA guidelines.FindingsA total of 4,404 studies were screened, 162 full‐text studies were assessed against the inclusion and exclusion criteria, and a total of six studies were included. The meta‐aggregation developed three overarching synthesised findings which were as follows: (a) empowering parents to become involved, (b) effective communication to recognise mutual expertise and (c) collaborative nurse–family relationships.ConclusionParents valued collaboration where both parents and nurses are recognised equally for their skills and expertise. A power struggle existed between parents and nurses when expertise was not recognised. Parents appreciated nurses who empowered them to develop new skills and knowledge in the care of their own child.Relevance to clinical practiceNurses need to recognise the skills and knowledge that parents have surrounding the care requirements of their own children. Collaboration and negotiation are key to successful partnership between nurses and parents. Nurses need to frequently reflect on how they are successfully partnering with both parents and children and ensure all parties in the nurse/parent/child triad feel supported and empowered.
Relationships of organisational justice, psychological capital and professional identity with job burnout among Chinese nurses: A cross‐sectional study
Authors: Ren Zheng , Zhang Xiumin , Li Xiangrong , He Minfu , Shi Hong , Zhao Hanfang , Zha Shuang , Qiao Shuyin , Li Yuyu , Pu Yajiao , Fan Xinwen , Guo Xia , Sun Yan , Liu Hongjian 
Published: April 2021

AbstractAims and objectivesThe present study was aimed at describing the status of job burnout and exploring the mediating roles of psychological capital and professional identity on the association between organisational justice and job burnout.BackgroundWith the shortage of nurses all over the world, nurses’ job burnout has become the focus of studies in recent years. However, limited published research has examined the mediating roles of psychological capital and professional identity on the association between organisational justice and job burnout within hospital contexts in China.DesignA cross‐sectional design.MethodsA total of 1,009 nurses were enrolled from a major general hospital located in Qiqihar City in the northeast of China from March–July 2018, and asked to complete questionnaires regarding organisational justice, psychological capital, professional identity and job burnout. The STROBE checklist was adhered to in this study.ResultsIt was observed that the overall proportion of nurses with job burnout was 58.8%. All the correlations among organisational justice, psychological capital, professional identity and job burnout were statistically significant, with coefficients ranging between −0.487–0.863. Psychological capital and professional identity had indirect effects equal to −0.072 and −0.142, respectively, on the association between organisational justice and job burnout, taking up 13.7% and 26.9% of the total effect, respectively. The serial indirect effect of psychological capital and professional identity was −0.129, accounting for 24.5% of the total effect.ConclusionsThis study showed the necessity of addressing the status of job burnout among Chinese nurses. Psychological capital and professional identity may mediate the linkage between organisational justice and job burnout independently and accumulatively.Relevance to clinical practiceNursing managers should strengthen organisational justice and improve the psychological capital and professional identity of nurses through effective strategies to prevent the job burnout of nurses.
Communal collective narcissism
Authors: Żemojtel‐Piotrowska Magdalena , Piotrowski Jarosław , Sedikides Constantine , Sawicki Artur , Czarna Anna Z. , Fatfouta Ramzi , Baran Tomasz 
Published: April 2021

AbstractObjectivesWe aimed to introduce, validate, and showcase the utility of a new construct: communal collective narcissism.MethodWe conducted four studies, in which we developed a new scale for communal collective narcissism (Study 1, N = 856), tested the construct's unique predictions (Study 2, N = 276), examined its social relevance (Study 3, N = 250), and assessed its implications for intergroup outcomes (Study 4, N = 664).ResultsIn Study 1, we verified the structural soundness of the Communal Collective Narcissism Inventory. In Study 2, we obtained evidence for a defining feature of communal collective narcissism, namely, that it predicts communal, but not agentic, ingroup‐enhancement. In Study 3, we illustrated the social relevance of communal collective narcissism. Communal collective narcissists derogated outgroup members, if those outgroups threatened the ingroup and the threat targeted the ingroup's communion. Finally, in Study 4, we showed that communal collective narcissism predicts intergroup outcomes in the communal domain (e.g., humanitarian aid) better than agentic collective narcissism does, whereas agentic collective narcissism predicts intergroup outcomes in the agentic domain (i.e., preferences for military aggression) better than communal collective narcissism does.ConclusionsThe construct of communal collective narcissism is conceptually and empirically distinct from classic (i.e., agentic) collective narcissism.
Familial hypercholesterolaemia: Experience of a tertiary paediatric lipid clinic
Authors: Yeung Jeffrey , Chisholm Kerryn , Spinks Catherine , Srinivasan Shubha 
Published: April 2021

AimTo review the experience of a dedicated paediatric multidisciplinary lipid clinic in the management of familial hypercholesterolaemia (FH) by studying the demographics, clinical presentations as well as statin therapy and outcomes.MethodsRetrospective database review of all patients under 18 years old seen in the lipid clinic at an Australian tertiary paediatric hospital between April 1999 and August 2017. Outcome measures collected included patient demographics, family history, lipid profile, age at treatment commencement, treatment outcomes and complications.ResultsOne hundred and eight patients (53 males) were seen in the lipid clinic. Eighty‐five had low‐density lipoprotein cholesterol (LDL‐C) levels at or above the 75th percentile for sex prior to treatment. Of these, 75 had a first‐degree relative with hypercholesterolaemia and/or early cardiac death. Four patients had clinical manifestations. Thirty‐two patients (14 males) were started on statin therapy for likely FH. LDL‐C levels reduced by 2.4 mmol/L (1.4 to 2.7) in boys and 1.9 mmol/L (0.8 to 2.8) in girls at 12 month follow‐up. Five patients reported side effects requiring adjustment in therapy. Main reasons for not starting statin therapy in eligible patients were parental refusal and/or lost to follow up (77%).ConclusionA dedicated multidisciplinary lipid clinic is helpful for streamlining and monitoring management of paediatric FH. Clinical manifestations of FH are rare in children and may represent more severe form of FH or other lipid disorder. Statin therapy is efficacious and well tolerated but current recommended targets of treatment are difficult to attain. Greater awareness and coordinated services are required to overcome poor family engagement.