bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efek Antidiabetik Dari Aloe Vera
Authors: Larasati Cantika 
Published: March 2021

Diabetes melitus merupakan kelainan metabolisme kronis yang ditandai dengan hiperglikemia dengan gangguan metabolisme karbohidrat, lemak, dan protein. Pasien dengan diabetes mellitus seringkali memiliki kontrol glikemik yang buruk dan memiliki banyak risiko komplikasi mikrovaskuler. Obat hipoglikemik sintetik tidak dapat sepenuhnya mengontrol kadar glukosa serta seringkali menimbulkan efek samping yang menyebabkan ketidakpatuhan pasien minum obat. Selama berabad-abad, obat-obatan herbal telah banyak digunakan untuk mengobati berbagai macam penyakit yang sampai saat ini masih digunakan sebagai alternatif pertama untuk menyembuhkan penyakit tertentu di negara berkembang. Aloe vera telah digunakan oleh berbagai budaya karena khasiat obatnya yang luar biasa. Penelitian ini merupakan literature review yang melibatkan sebanyak 21 sumber pustaka dengan kata kunci yang digunakan yaitu ‘aloe vera dan diabetes’ dengan tahun terbit antara 2009- 2020. Abstrak dan full text jurnal dibaca dan dicermati, kemudian dilakukan analisis terhadap isi yang terdapat dalam tujuan penelitian dan hasil/temuan penelitian. Banyak studi menunjukkan ekstrak aloe vera dapat berperan dalam menurunkan glukosa darah pada penderita diabetes mellitus dan komplikasinya melalui berbagai mekanisme, seperti menurunkan glukoneogenesis dan lipogenesis, serta meningkatkan glikolisis di hati. Selain itu, aloe vera dapat mempengaruhi ekspresi gen berbeda yang terkait dengan metabolisme glukosa dan lipid. serta dikaitkan dengan aktivasi transkripsi PPAR. Kandungan senyawa dan vitamin didalamnya juga berperan sebagai antioksidan. Kandungan senyawa pada gel aloe vera menunjukkan berbagai manfaat antidiabetes, dan kandungan polisakarida di dalamnya dianggap sebagai komponen aktif utama untuk manfaat tersebut.
Hepatic involvement in patient with asia syndrome
Authors: Martos Ruiz V , Cascales Vallejo AI , García Cortacero E 
Published: March 2021

Resumen

El nombre de síndrome autoinmune /inflamatorio inducido por adyuvantes (Síndrome ASIA o de Shonefeld) se relaciona con la exposición típicamente de alguna de estas sustancias: vacunas (especialmente papiloma humano), silicona, escualeno, hidróxido de aluminio, parafina líquida, acrilamidas, ácido hialurónico o metacrilato. Puede dar manifestaciones inflamatorias tanto locales como sistémicas. Presentamos el caso de una paciente con prótesis de silicona en mamas y tatuaje de piel y labios, en estudio por hepatitis de perfil colestásico, en la que aparecen lesiones cutáneas que se biopsian (granulomas no necrotizantes), siendo esto clave para el diagnóstico de reacción sarcoidítica.
Rethinking the Concept of Autonomy for the Sociology of Symbolic Goods
Authors: Sapiro Gisèle 
Published: March 2021

This paper revisits the uses of the concept of autonomy in sociological analysis of the conditions of production and circulation of symbolic goods. Part 1 provides an overview of autonomy in three intellectual traditions: the sociology of professions, Marxist reflection theory, and field theory. Despite some divergences and the partial incompatibility of their uses of the concept, there are areas of overlap and possible linkages between these approaches, investigated in Part 2. These lead us, in Part 3, to formulate proposals towards a reasoned synthesis of these uses for the sociology of the production and circulation of symbolic goods.
Elevated P-Selectin in Severe Covid-19: Considerations for therapeutic options
Authors: Agrati Chiara , Bordoni Veronica , Sacchi Alessandra , Grassi Germana , Petrosillo Nicola , Nicastri Emanuele , Del nonno Franca , D'offizi Giampiero , Palmieri Fabrizio , Marchioni Luisa , Capobianchi Maria rosaria , Antinori Andrea , Ippolito Giuseppe , Bibas Michele 
Published: March 2021

BACKGROUND:
Coronavirus disease 2019 (COVID-19) is mainly a respiratory tract disease and acute respiratory failure with diffuse microvascular pulmonary thrombosis are critical aspects of the morbidity and mortality of this new syndrome.
PURPOSE:
The aim of our study was to investigate, in severe COVID-19 hospitalized patients, the P-selectin plasma concentration as a biomarker of endothelial dysfunction and platelet activation.
METHODS:
46 patients with severe or critical SARS-CoV-2 infection were included in the study. Age-matched patients then were divided in those requiring admission to the intensive care unit (ICU, ICU cases) vs those not requiring ICU hospitalization (non-ICU cases). Blood samples of severe COVID-19 patients were collected at the time of hospital admission. The quantification of soluble P-selectin was performed by ELISA assay.
RESULTS:
Our study showed a higher P-selectin plasma concentration in patients with Covid-19, regardless of ICU admission, compared to the normal reference values and compared to ten contextually sampled healthy donors (HD); (COVID-19): median 65.2 (IQRs: 45.1-81.1) vs. HD: 40.3 (IQRs: 24.3-48.7), p=0.0023). Moreover, results showed a significant reduction of P-selectin after platelets removal in HD, in contrast, both ICU and non-ICU COVID-19 patients showed similar high levels of P-selectin with and without platelets.
CONCLUSION:
Elevation of P-selectin suggests a central role of platelet endothelium interaction as part of the multifaced pathogenic mechanism of COVID-19 leading to the local activation of hemostatic system forming pulmonary thrombi. Further work is necessary to determine the therapeutic role of antiplatelets agents or of the anti P-selectin antibody Crizanlizumab.
Real world data on characteristics and management of community patients receiving anticoagulation therapy who presented with acute bleeding to the emergency department at a regional Australian hospital: A prospective observational study.
Authors: Hanna Fayez , Hyppa Annemarie , Prakash Ajay , Vithanarachchi Usira , Dawar Hizb U , Sanga Zar , Olabode George , Crisp Hamish , Khalafallah Alhossain A. 
Published: March 2021

Objective: To study patients receiving anticoagulants with or without antiplatelet therapy presenting at a regional Australian hospital with bleeding. The main aims are to explore: (1) patients’ characteristics and management provided; (2) association between the type of anticoagulant and antiplatelet agent used and the requirement of reversal; (3) and the length of hospital stay (LoS) in conjunction with bleeding episode and management.
Methods: A prospective cross-sectional review of medical records of all patients who presented at a tertiary referral centre with bleeding while receiving anticoagulation therapy between January 2016 and June 2018. Data included: demographics, investigations (kidney and liver function tests, coagulation profile, FBC), LoS, bleeding site, type of and reason for anticoagulation therapy, and management provided. Data analysis included descriptive statistics, ?2 association, and regression models.
Results: Among the 144 eligible patients, 75 (52.1%) were male, and the mean age was 76 years (SD=11.1). Gastrointestinal tract bleeding was the most common (n=48, 33.3%), followed by epistaxis (n=32, 22.2%). Atrial fibrillation was the commonest reason for anticoagulation therapy (n=65, 45.1%). Warfarin was commonly used (n=74, 51.4%), followed by aspirin (n=29, 20.1%), rivaroxaban (n=26, 18.1%), and apixaban (n=12, 8.3%). A majority had increased blood urea nitrogen (n=67, 46.5%), while 58 (40.3%) had an elevated serum creatinine level, and 59 (41.0%) had a mild reduction in eGFR. Thirty-five of the warfarinised patients (47.3%) had an INR above the target range of their condition despite normal liver function. Severe anaemia (Hb<80g/L) was reported in 88 patients (61.1%). DOACs were associated with a reduced likelihood of receiving reversal (B= -1.7, P=<.001), and with a shorter LoS (B= -4.1, P=.046) when compared with warfarin, LMWH, and antiplatelet therapy.
Conclusion: Warfarin use was common among patients who presented with acute bleeding, and the INR in many warfarinised patients exceeded the target for their condition. DOACs were associated with a reduced likelihood for receiving reversal and with a shorter LoS when compared to warfarin, LMWH, which might support wider application of DOACs into community practice.
Diagnostic accuracy of clinical tool ‘STOPS’ and Serum Procalcitonin for optimizing antibiotic therapy in Neonatal Sepsis
Authors: Tewari Vishal Vishnu 
Published: March 2021

Background: Antibiotic therapy is initiated in neonates on suspicion of sepsis. Optimizing therapy is a felt need of clinicians as injudicious prolonged use increases mortality and morbidity risk.
Objective: To evaluate the diagnostic accuracy of clinical tool ‘STOPS’ and serum procalcitonin (PCT) for identifying neonates with early onset neonatal sepsis (EONS) or late onset neonatal sepsis (LONS) and early discontinuation in those with no sepsis.
Methods: The study had a prospective analytical design conducted at a tertiary care hospital. All neonates with suspected EONS or LONS were enrolled. The ‘STOPS’ tool comprising of sensorium, temperature, oxygenation, perfusion, skin color and blood sugar was applied at 6 and 12 hr of enrollment. Serum PCT was sent at 12 hr. The sensitivity, specificity, positive and negative predictive value (PPV and NPV), positive and negative likelihood ratio (PLR and NLR) were estimated.
Results: The study enrolled 380 neonates of which 330 were given antibiotics for EONS and 50 for LONS. Temperature recording in the EONS group at 12 hr showed a PPV of 100% and a PLR of 9.1 (7.7 – 18). Perfusion assessment at 12 hr had a PPV of 77% and PLR of 8.25 (2.3 – 29). Skin color assessment at 12 hr it had a PPV of 100% and PLR of 13.5 (9.7 – 27). The diagnostic accuracy of PCT in the EONS group was unremarkable. In the LONS group, skin color at 12 hr had a PPV of 100% and PLR of 11.2 (8.6 – 19.5). The diagnostic accuracy of PCT in the LONS group showed a PPV of 82% and PLR of 7 (1.7 – 29).
Conclusion: Identifying abnormal STOPS parameters was superior to PCT alone in EONS and as good as PCT in LONS. The ‘STOPS’ tool allows early identification of neonates with no sepsis thereby optimizing antibiotic use.
ANALYSIS OF HEALTH-SEEKING BEHAVIOR OF TUBERCULOSIS PATIENTS IN NIGERIA
Authors: Tayo-Ladega Oluwadamisi , Abdullahi Taye Mohammed 
Published: March 2021

Among several forms of infectious diseases, tuberculosis (TB) cannot be exempted. Even though the treatment of TB is free in Nigeria, the costs incurred by most patients do not reveal the significance of free treatment, and this affects the behavioral pattern of TB patients as a result of the numerous visits of patients to the hospital during the treatment of TB which may or may not yield their expected result. The objective of this study is to examine the behavior of TB patients towards seeking help for their health conditions. The study focused on Kwara and Kebbi States, Nigeria. The findings revealed that most of the Tuberculosis patients were more likely to search for treatment and seek medical advice from secondary health facilities, and they sought treatment first at the out-patient services. The out-patient services are among the secondary health facilities. It is therefore recommended that there is a need for health stakeholders (private and public) to ensure primary health coverage for all patients to prevent the exclusion of certain persons from treatment. This is referred to as inclusiveness.
JEL Classification Codes: A19, B10, B25, C10, C53.
Postoperative Functional and Radiological Outcome Comparison of Computer-assisted and Conventional Total Knee Arthroplasty at 6 Months Follow-up: A Cross Sectional Study
Authors: Budimansyah Muhammad , Dilogo Ismail Hadisoebroto , Sumargono Endrotomo 
Published: March 2021

Background. Computer-assisted navigation TKA has just been adapted in Indonesia for the last decade. The method is aiming to achieve more precise mechanical alignment in TKA. However, controversies still exist especially in terms of functional outcome and radiological outcome.Method. Fifty elderly patients aged more than 50 years old with severe knee osteoarthritis (Kellgren Lawrence stage III or IV) who scheduled for TKA surgery in the first half of 2019 were consecutively sampled. All patients were measured for objective functional status with Western Ontario Mac Master University Index (WOMAC) and Oxford Knee Score (OKS). Weight-bearing, long-leg follow-up radiographs of both lower limbs were taken, and coronal tibiofemoral angle (CTFA), coronal femoral component angle (CFCA) and coronal tibial component angle (CTCA) were measured.Results. Group of computer-assisted navigation TKA surgery was found to have significantly lower WOMAC score (p0.05) and higher OKS score (p0.05). Although not statistically significant, greater angle of deviation is observed in the conventional TKA surgery group. Proportions with deviation of less than 3º were found more in the group using computer navigation.Discussion. The results of this study indicate the advantage of using a computer assisted system in TKA procedure, in terms of better functional outcome. However, our study only measures mechanical alignment from coronal plane and short term follow up time. Other parameter measurement, such as mechanical alignment on sagittal plane, rotational alignment, and soft tissue balance are also important to determine the success rate of TKA procedure.Conclusion. Patients who had TKA surgery under computer-assisted navigation would benefit a better functional outcome if compared with conventional TKA surgery, as measured with WOMAC and OKS. However, there is no significant difference in terms of radiographic value of coronal-plane mechanical deviation on both methods.
The impact of the COVID-19 pandemic on hip and knee arthroplasty: A systematic review
Authors: Phatama Krisna Yuarno , Oktafandi I Gusti Ngurah Arga Aldrian , Cendikiawan Felix , Mustamsir Edi 
Published: March 2021

Background: In order to ameliorate the burden the coronavirus disease 2019 (COVID-19) pandemic had on the medical resources, and to ensure the safety of orthopaedic patients and medical personnel, some hip and knee arthroplasties, as forms of elective surgeries, were suggested to be canceled or postponed. This review aims to analyze the available literature on the impact of COVID-19 pandemic on all areas surrounding hip and knee arthroplasty service. Materials and Methods: A systematic literature search was conducted in five databases from July 5th to 10th, 2020. We included studies that assessed any impacts the COVID-19 pandemic had on the patients who require hip or knee arthroplasty, hip and knee surgeons, and any other areas that are related to hip and knee arthroplasty service. We excluded studies that do not report complete clinical results, reviews, editorials, and letters.Results: After the screening, a total of nine articles were selected. Two studies evaluated the impact of COVID-19 on the hip and knee arthroplasty patients, one study on public interest in hip and knee arthroplasty, three studies on the hip and knee arthroplasty surgeons, two studies on surgical volume, and one study on industry partners. Of 360 surveyed patients, 60% felt anxious about the uncertainty of the rescheduled arthroplasty. Of 1770 surveyed surgeons, 61.9%, 54.7%, and 20.9% of them reported canceled elective inpatient procedures, outpatient procedures, and all types of surgeries, respectively.Conclusions: COVID-19 pandemic had some impacts on the patients, public interest, surgeons, industry partners, and hip and knee arthroplasty volume.
LATERAL MENISCUS TEARS IN ACL INJURED KNEE
Authors: Tapasvi Sachin 
Published: March 2021

Anterior cruciate ligament (ACL) tears can be associated with injuries to the lateral meniscus (LM) in about 20-30% cases. The lateral meniscus is more mobile than the medial and besides contributing to load transmission, it also stabilizes the knee in pivot-shift testing. The LM tears more often in the acute setting and its incidence does not rise in cases of chronic ACL instability. Lateral meniscus tears can be minor or major depending how severely the knee function gets impaired. Major tears are the complete radial tears, longitudinal bucket handle tears and posterior root tears. Male gender, high body mass index and contact injury mechanism are all risk factors for an LM tear. Anatomic factors which can contribute to LM tears include a high posterior tibial slope, varus malalignment and greater asymmetry between medial and lateral slopes. The lateral meniscus must be saved and repaired whenever possible to prevent residual knee instability and progressive lateral compartment arthritis, which can set in soon after a meniscectomy. The development of techniques and technology have rendered most tears amenable to repair. Longitudinal tears can be repaired by the all-inside or inside-out technique and the needles and devices must be inserted through a high anteromedial or transpatellar portal to prevent injury to the popliteal neurovascular structures. A lateral safety incision must always be used for inside-out repairs. Radial tears can be repaired by two horizontal sutures, a cross stich, a cross-tag or a hash-tag suture configuration. Lateral meniscus posterior root repairs are repaired by transtibial technique, either by drilling an independent anatomic tunnel or the sutures pulled out via the ACL tibial tunnel. The lateral meniscus has high healing rates and repairs yield improvement in functional outcome, beside delaying radiographic arthritis.
ÉRTÉKET NEM TEREMTŐ FOLYAMATOK FELTÁRÁSA VSM MÓDSZER ALKALMAZÁSÁVAL EGY KIS VÁLLALKOZÁS GYÁRTÓRENDSZERÉNEK ESETTANULMÁNYÁN KERESZTÜL.
Authors: Thalmeiner Gergő , Harmat Vanda , Gáspár Sándor 
Published: March 2021

Hazánk egyik jelentős problémája a termelékenység alacsony szintje. Ez az alacsony szint pedig kiemelkedően jellemző a kis- és közép vállalkozások körében. A legtöbb régiós és a nyugat-európai országokban ezen méretű vállalkozások átlagos termelékenységi szintje magasabb, mint hazánkban. A jelenlegi és várhatóan a közeljövőben is jelen lévő munkaerőhiányos környezet a vállalkozásokat kihívás elé állítja. A munkaerő megtartásához hozzájáruló bérnövekedés megteremtése hosszútávon kizárólag a termelékenység növelésével biztosítható. Ha a szervezet nem képes a termelékenység növelésének elérésére, alul marad mind a hazai, mind pedig a nemzetközi-globális versenyben.
A hazai kis- és középvállalkozások termelékenységének és a versenyképességének növelésében kulcs elem lehet a modern gazdálkodásszervezési és menedzsment rendszerek, például a lean menedzsment alkalmazása. A lean menedzsment az egyik leggyakoribb és leghatékonyabb folyamatszervezési módszer, illetve paradigma, amelyet a szekunder és tercier szektorokban bevált módon alkalmaznak, olyannyira, hogy a lean szemléletre épülő menedzsment módszerek alkalmazása sok esetben versenykritériummá, és alapvetővé vált.
Kutatásunkban egy CNC fémforgácsoló KKV folyamatait, azon belül is a CNC marási és esztergálási folyamatok értékfolyamat feltérképezését készítjük el. Ez az értékfolyamat feltérképezési módszer lehetőséget kínál arra, hogy az ágazatban felmerülő veszteségek megismerhetővé és kiküszöbölhetővé váljanak. A térkép elkészítésén keresztül megvalósítható a mudákat termelő folyamatok szemléltetése és ezáltal az átfutási idő csökkentése, illetve a termelékenység növekedése. Vizsgálatunk során egy CNC technológiával megmunkált fémalkatrészeket gyártó vállalkozás példáján keresztül mutatjuk be a módszer gyakorlati megvalósulását.
Reflective journals as a developmental tool in PAL
Authors: Gentle Carolyn , Shaw Rachel , Scott Sophie 
Published: March 2021

Reflection is frequently used as a means towards evaluating and improving performance.ÃÂ In the context of peer learning, post-session debriefs are reflective conversations between Peer Assisted Learning (PAL) leaders and their Academic Co-ordinators. Reflection-for-action (Killion and Todnem, 1991) is a good fit with peer learning which is typically action-oriented. ÃÂ This case study considers the extent to which a PAL leaderÃ¢â¬â¢s professional capability and personal development may be further boosted by keeping a reflective journal. It raises the question whether or not there are tangible benefits to the journal-keeper in terms of their perceptions of their own learning, soft skills and employability. ÃÂ A PAL leader at a UK university who kept a reflective PAL journal found the process enriching and it led to some changes in thought in respect of assumptions about what PAL success could look like. ÃÂ ÃÂ
Opinion piece: A call to unite in a common cause
Authors: Rust Chris 
Published: March 2021

This opinion piece argues that despite the successes of the Learning Development network, and the learning development community, separate development of this community may also have some dangers. It further argues that now is an auspicious time to try and bring about a paradigm shift in the attitudes of academic staff towards their role as teachers in higher education. Having presented the reasons why, it suggests that in order to increase the chances of bringing this about, the learning development and educational development communities should come together.
Significant Personal Disclosure: exploring the support and development needs of HE tutors engaged in the emotion work associated with supporting students.
Authors: Huyton Jan Louise 
Published: March 2021

This paper explores emotion work taking place in the private and personalized space of supportive encounters between individual students and tutors. An emotional labour framework is used to consider the effects on tutors of work intensification and performance requirements in learning relationships with students. The paper goes on to consider professional role boundaries and staff development, training and support. The paper concludes that institutions need to recognize the existence of emotion work as a pedagogy in the context of student support or learning development. Failure to do so will have detrimental effects on tutors and the service they provide to students.
Maximising student learning through minimising information search time; the role of satisficing and skimming.
Authors: Wilkinson Susan 
Published: March 2021

With the increase in the use of the internet for educational purposes, the problem is no longer how to find and access information on-line, but how to select the most appropriate sources of information. What strategies do students adopt in order to allocate time adaptively to the information they need to learn? How and when do they make decision judgements, and how can this enable educators to facilitate student learning? If we understand how students search and retrieve information from texts, then we can design our texts to facilitate this process and ultimately enhance learning through minimising the time it takes for students to search for information within a text, and maximise the time they have for learning that information. This paper will present a new and innovative model of adaptive allocation of time across on-line texts, based on the principles of satisficing and skimming. It will discuss how knowledge about students' information search and retrieval processes can aid educational text designers in designing texts that will enhance student learning.