bluuebunny/crossref_metadata_2025_split huggingface dataset:
B.1.1.529 escapes the majority of SARS-CoV-2 neutralizing antibodies of diverse epitopes
Authors: Xie Xiaoliang , Cao Yunlong , wang jing , Jian Fanchong , Xiao Tianhe , Song Weiliang , Yisimayi Ayijiang , Li Tao , Yu Yuanling , Wang Yao , Wang Jing , Niu Xiao , Wang Peng , An Ran , Liang Hui , Sun Haiyan , Yang Sijie , Cui Qianqian , Liu Shuo , Du Shuo , Zhang Zhiying , Shao Fei , Huang Weijin , Xiao Junyu , Wang Youchun , Wang Xiangxi , Yang Xiaodong , Li Qianqian , Hao Xiaohua , Ronghua Jin 
Published: December 2021

Abstract
The SARS-CoV-2 B.1.1.529 variant (Omicron) contains 15 mutations on the receptor-binding domain (RBD). How Omicron would evade RBD neutralizing antibodies (NAbs) and humoral immunity requires immediate investigation. Here, we used high-throughput yeast display screening1,2 to determine the RBD escaping mutation profiles for 247 human anti-RBD NAbs identified from SARS-CoV/SARS-CoV-2 convalescents and vaccinees. Based on the results, NAbs could be unsupervised clustered into six epitope groups (A-F), which is highly concordant with knowledge-based structural classifications3-5. Strikingly, various single mutations of Omicron could impair NAbs of different epitope groups. Specifically, NAbs in Group A-D, whose epitope overlaps with ACE2-binding motif, are largely escaped by K417N, N440K, G446S, E484A, Q493K, and G496S. Group E (S309 site)6 and F (CR3022 site)7 NAbs, which often exhibit broad sarbecovirus neutralizing activity, are less affected by Omicron, but still, a subset of NAbs are escaped by G339D, S371L, and S375F. Furthermore, B.1.1.529 pseudovirus neutralization and RBD binding assay showed that single mutation tolerating NAbs could also be escaped due to multiple synergetic mutations on their epitopes. In total, over 85% of the tested NAbs are escaped by Omicron. Regarding NAb drugs, LY-CoV016/LY-CoV555 cocktail, REGN-CoV2 cocktail, AZD1061/AZD8895 cocktail, and BRII-196 were escaped by Omicron, while VIR7831 and DXP-604 still function at reduced efficacy. Together, data suggest Omicron could cause significant humoral immune evasion, while NAbs targeting the sarbecovirus conserved region remain most effective. Our results offer instructions for developing NAb drugs and vaccines against Omicron and future variants.
Dietary Diversity among Indian adolescents and young adults: Evidence from UDAYA study
Authors: Bansal Anjali , Arora Pooja , Sharma Radhika , Misra Archa 
Published: December 2021

Abstract
Background: Adolescence is a period transition from childhood to adulthood , in which they undergo various rapid changes from physical appearances to changes in the food habits. During this period, childbearing age starts, particularly for women, which is one of the most precarious time wherein optimum nutritional status need to be achieved. So, Eating healthy during adolescence is important as rapid physical growth increases the need of several nutrients.Methods: In our study, we have used the UDAYA longitudinal study design which provides a unique opportunity to determine the role of dietary pattern at one time point to the changes at the time 2. For analysis, cross-tabulation and chi-square test is used to test independence of various groups. Binary logistic regression is used to identify determinants of minimum dietary diversity (Yes=1, No=0) of the adolescents. Adjusted odds ratio are computed for Uttar Pradesh and Bihar separately, as well as for combined sample.Results: In the present study, the average adherence to the dietary pattern in our adolescents was 58%, while in Bihar it was 61% , and in UP it was 56%. Using the logistic regression analysis, we found that there was significant difference in the MDD of adolescents by their socio-economic characteristics. But no differentials were found among young and old adolescents in UP and Bihar. Also, food consumption score index (A.O.R.=2.6, 95% CI (2.1-3.1), and media exposure of adolescents at wave1 (A.O.R.=2.1, 95% CI (1.7-2.7) were found significant in depicting the MDD at wave2. Conclusions: India launched ICDS scheme in 1975s to strengthen the nutritional status of young children in the country, but the recent data of NFHS-5 (2019-20), shows that the nutritional status of the country improved only marginally, or rather decreased in some parts. Strengthening and proper evaluation of ICDS programme can help to improve the pro-nutrition among the adolescents. Also, there should be a specific state policy to address the needs of adolescents, and various educational programmes should be conducted in schools where students along with their parents should be educated about the need of healthy dietary habits.
Dissociation of Early And Late Face-Related Processes In Autism Spectrum Disorder And Williams Syndrome
Authors: Gomez Alice , Lio Guillaume , Costa Manuela , Sirigu Angela , Demily Caroline 
Published: December 2021

Abstract
Background: Williams syndrome (WS) and Autism Spectrum Disorders (ASD) are psychiatric conditions associated with atypical but opposite face-to-face interactions patterns: WS patients overly stare at others, ASD individuals escape eye contact. Whether these behaviors result from dissociable visual processes within the occipito-temporal pathways is unknown. Using high-density electroencephalography, multivariate signal processing algorithms and a protocol designed to identify and extract evoked activities sensitive to facial cues, we investigated how WS (N=14), ASD (N=14) and neurotypical subjects (N=14) decode the information content of a face stimulus. Results: We found two neural components in neurotypical participants, both strongest when the eye region was projected onto the subject's fovea, simulating a direct eye contact situation, and weakest over more distant regions, reaching a minimum when the focused region was outside the stimulus face. The first component peaks at 170ms, an early signal known to be implicated in low-level face features. The second is identified later, 260ms post-stimulus onset and is implicated in decoding salient face social cues.Remarkably, both components were found distinctly impaired and preserved in WS and ASD. In WS, we could weakly decode the 170ms signal based on our regressor relative to facial features, probably due to their relatively poor ability to process faces’ morphology, while the late 260ms component was highly significant. The reverse pattern was observed in ASD participants who showed neurotypical like early 170ms evoked activity but impaired late evoked 260ms signal. Conclusions: Our study reveals a dissociation between WS and ASD patients and point at different neural origins for their social impairments.
Food insecurity and common mental disorders in perinatal women living in low socio-economic settings in Cape Town, South Africa during the COVID-19 pandemic: a cohort study
Authors: Abrahams Zulfa , Lund Crick 
Published: December 2021

Abstract

Background
Common mental disorders (CMDs) such as depression and anxiety are highly prevalent during the perinatal period, and are associated with poverty, food insecurity and domestic violence. We used data collected from perinatal women at two time-points during the COVID-19 pandemic to test the hypotheses that (1) socio-economic adversities at baseline would be associated with higher CMD prevalence at follow-up and (2) worse mental health at baseline would be associated with higher food insecurity prevalence at follow-up.
Methods
Telephonic interviews were conducted with perinatal women attending healthcare facilities in Cape Town, South Africa. Multivariable logistic regression analysis was used to model the associations of baseline risk factors with the prevalence of household food insecurity and CMD at 3 months follow-up.
Results
At baseline 859 women were recruited, of whom 217 (25%) were pregnant, 106 (12%) had probable CMD, and 375 (44%) were severely food insecure. At follow-up (n=634), 22 (4%) were still pregnant, 44 (7%) had probable CMD, and 207 (33%) were severely food insecure. In the multivariable regression model, after controlling for confounders, the odds of being food insecure at follow-up were greater in women who were unemployed [OR=2.05 (1.46-2.87); p<0.001] or had probable CMD [OR=2.37 (1.35-4.18); p=0.003] at baseline; and the odds of probable CMD at follow-up were greater in women with psychological distress [OR=2.81 (1.47-5.39); p=0.002] and abuse [OR=2.47 (1.47-4.39); p=0.007] at baseline.
Conclusions
This study highlights the complex bidirectional relationship between mental health and socioeconomic adversity among perinatal women during the COVID-19 pandemic.
Using I2P Encrypted Virtual Tunnels for a Secure and Anonymous Communication in VANets: I2P Vehicular Protocol (IVP)
Authors: Diab Tayeb , Gilg Marc , Drouhin Frederic , Lorenz Pascal 
Published: December 2021

Abstract
Providing security and anonymity within VANet requires application of robust and secure models that meet several characteristics of VANet. I2P as a secure protocol designed to anonymize the communication on the internet, can be used as a reference model to develop new mechanisms of security and anonymity in VANet. I2P uses robust mechanisms and strong algorithms to reinforce the security and the anonymity of the communication. However, the difference between internet and VANet in terms of mobility and connectivity of nodes presents a big issue that needs to be treated when using I2P mechanisms in VANet. In the previous work [1], we propose a protocol based on tunnels and encryption algorithms that use digital signatures and authentication mechanisms. Tunnels are created in static scenarios and without maintaining their existence. In this paper, we complete the last version of the proposed protocol (I2P Vehicular Protocol) by integrating a tunnel maintenance algorithm for maintaining the existence of the created tunnels during the communication. This algorithm allows the implementation of the protocol in mobile scenarios of VANet. The effectiveness and security of IVP protocol are proved by analyzing the added part related to the tunnel maintenance process and showing performance results (end-to-end delay, PDR and overhead). Simulation scenarios were executed using NS3 simulator.
Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors Induced Neurocognitive Disorder: A Pharmacovigilance Study by Analyzing the Data from the U.S. FDA Adverse Event Reporting System
Authors: Hu Yang , Bai Ziyu , Huang Tianxin , Zhang Xinyue , Fan Qianqian , Zhao Bin , Tian Zhuang 
Published: December 2021

Abstract
PurposeThe neurocognitive disorder is a rare adverse event associated with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) inhibitors in the randomized controlled trail (RCTs), there was limited evidence to prove their relation. This study aimed to assessing their association by detecting adverse signal in the FDA Adverse Event Reporting System (FAERS).MethodsThe disproportionality analysis was conducted to detect the potential adverse signal between neurocognitive disorders and PCSK9 inhibitors. The adverse event reports from the first quarter of 2004 to the second quarter of 2020 were extracted from the FAERS database.ResultsThere were 81,272 adverse reports correlated with the usage of the PCSK9 inhibitors, of which 152 reports corresponded with our inclusion criteria. Among them, there were 106 and 46 neurocognitive disorder reports related to the usage of Evolocumab and Alirocumab, respectively. The total ROR value presented negative disproportionality, however, Alirocumab has generated a positive signal with a higher ROR value in comparison with Evolocumab. Moreover, there were 61.19% of adverse reports were submitted by healthcare professionals. As for the outcome events, 7.79% of patients had initial or prolonged hospitalization and 3.90% suffered a disability.ConclusionThe pharmacovigilance research helps to find out more about PCSK9 inhibitor-related neurocognitive disorders. Although the positive signal was identified in Alirocumab in this study, it still required further research to prove the association between neurocognitive disorder and PCSK9 inhibitors. In addition, the tenable mechanism should be explored, which can improve the insight of this neotype lipid-lowering medicine.
Efficacy of Apatinib Combined with FOLFIRI in the First-Line Treatment of Patients with Metastatic Colorectal Cancer
Authors: Rong Xuetong , Liu Haiyi , Yu Hongmei , Zhao Jian , Wang Jie , Wang Yusheng 
Published: December 2021

Abstract
Objective: To evaluate the efficacy and safety of apatinib combined with FOLFIRI in the first-line treatment of advanced metastatic colorectal cancer (mCRC) and explore potential factors of efficacy. Methods: Twenty mCRC patients treated at Affiliated Cancer Hospital of Shanxi Medical University from March 2017 to March 2019 were included according to the enrolment criteria. They provided informed consent and were treated with apatinib combined with FOLFIRI according to the scheduled regimen until disease progression or unacceptable toxicity occurred. The primary endpoint was OS. The secondary endpoints included PFS, ORR, DCRand safety. OS and PFS were calculated using Kaplan-Meier curves. Univariate and multivariate Cox regression analyses were used to evaluate independent prognostic factors of OS and PFS. R was used to determine cut-off values for biochemical indicators. Forest maps were drawn for Cox univariate results and the relationships between NLR and ECOG, which were significant in univariate analysis, and OS were represented by Kaplan-Meier curves. Results: The median OS and PFS were 16.135 months (95% CI: 9.211–22.929) and 6 months (95% CI: 5.425–6.525). Multivariate Cox analysis showed that NLR and CEA were independent prognostic factors. The most common grade 3–4 adverse events were hypertension, diarrhoea, increased alkaline phosphatase, decreased leukocytes and decreased neutrophils. Conclusion: Apatinib combined with FOLFIRI for the first-line treatment of advanced unresectable mCRC showed good efficacy and safety. The baseline NLR was predictive of efficacy, and a low baseline NLR (HR: 0.2895, P=0.0084) was associated with improved OS.
Mode Selection of Content Delivery At Edge Nodes Based On Learning
Authors: Xu Yanli , Tang Hao 
Published: December 2021

Abstract
Pre-caching at edge nodes may improve resource efficiency for future content-centric cellular networks by bringing contents closer to users.
However, which mode (muticast or unicast) should be selected for the efficient delivery of those cached contents is still not well addressed, especially at the situation that some key parameters such as content popularity and transmission environments are unknown. To solve this problem, the criterion of delivery mode selection is studied based on the learning policy of multi-armed bandit(MAB). According to the criterion, a mode selection algorithm is proposed. In this algorithm, edge nodes can choose the better delivery modes in the current slot only dependent on existing observations in the previous slot. Performance evaluation results validate our analyses and proposals on the mode selection.
Penguatan Pendidikan Perempuan (Peran Perempuan dalam Agama, Keluarga, dan Kehidupan Sosial di Masa Modern)
Authors: Mannan Abd. , Farida Siti Nur , Rozy Fathorrozy 
Published: December 2021

Abstrak: Perempuan diangkat derajatnya setelah Islam datang, sehingga Islam memberikan hak yang sama antara pria dan wanita dalam hal pendidikan. pendidikan sangatlah dibutuhkan bagi setiap perempuan karena perempuan akan menjadi pendidikan utama bagi anak-anaknya, dan menjadi pendamping bagi suaminya serta dilingkungan masyarakat perempuan juga membutuhkan pendidikan. dalam hal pendidikan pria dan wanita adalah sama, hal ini merupakan buah revolusi begitupun sebaliknya. Adanya pendidikan memberikan hal positif bagi kaum laki-laki maupun perempuan untuk mengukir sejarah dimasa yang akan datang karena perempuan adalah pendamping yang harus berjuang bersama untuk memajukan bangsa serta meyongsong masa depan yang cerah dan perempuan bukanlah sosok bayangan yang harus ada dibelakang laki-laki. Sering kali perempuan dianggap pembawa malapetaka bagi dunia maupun lawan jenisnya padahal perempuan juga memiliki kewajiban untuk memajukan pendidikan bagi mereka yang tertindas. Maka dari itu perempuan sangatlah dihargai dan dihormati di dalam Islam karena merupakan suatu anugerah yang membawa kehidupan baru. Dalam kajian keislaman perempuan diberikan kesempatan untuk mengenyam pendidikan agar mereka mampu menjalankan hak dan kewajibannya baik sebagi perempuan pada umumnya maupun sebagai seorang istri.

Kata Kunci: Pendidikan Perempuan, Peran Perempuan, Masa Modern
Creative Sovereignties and Fiscal Relations
Authors: SOMMERS L. JAVED 
Published: December 2021

AbstractThis article contributes to conversations about creative sovereignties by exploring what truly ‘nation-to-nation’ fiscal relationships might look like between Canada and Treaty 6 First Nations if Treaty 6 were taken seriously. Since fiscal relations between Indigenous peoples and settler colonial states often perpetuate colonial sovereignty, reimagining fiscal relations in a historical treaty context offers creative opportunities for decolonization. The article first examines the history of the 1876 Treaty 6 and the relationships Treaty 6 created. It is established that Treaty 6 created nation-to-nation relationships that were based on the desire for mutually beneficial relations in a shared space, and that treaty included fiscal obligations for Canada. Since 1876, including today, fiscal relations between Canada and First Nations have generally been inconsistent with the spirit and intent of treaty. The article proceeds to offer examples of changes that could be made to create fiscal relationships consistent with treaty. Some of these recommendations are relatively pragmatic and would come at little political, fiscal, or constitutional cost to Canada, while others are more dramatic, and would involve a fundamental reshaping of Canada as we know it.
Between Ecology and Indigeneity
Authors: FISHEL STEFANIE , WINTER CHRISTINE J. , BURKE ANTHONY 
Published: December 2021

Abstract
We live at a time of unprecedented ecological and socio-political crisis—climate change, pandemic, extinction, inequality, and repression—yet everywhere it is underpinned by the dispossession of Indigenous peoples and the persistent refusal of Indigenous authority and sovereignty. Bringing together concerns about bio- and necropolitics, habitat destruction and animal cruelty, corporate-colonial modes of conservation, whitened food systems, and settler-colonial systems of land, business and environmental law, this special issue highlights enduring structures of injustice and creative lines of Indigenous resistance, authority, and cultural-political transformation.
A Seat At The Table
Authors: WINTER CHRISTINE J. 
Published: December 2021

Abstract
Aotearoa New Zealand acknowledges mātauranga Māori in the two Acts and one Memorandum of Understanding recognising the ‘personhood’ status of three geographical regions—Te Awa Tupua, Te Urewera and Taranaki Maunga. They blend the legal fiction of corporate personhood with the already always understanding of human-nonhuman kinship and entanglement of M!ori philosophy, Māori knowledge and wisdom, and Māori epistemology. Through kaitiaki (trustees) these three entities have volition in their ongoing maintenance, development negotiations, and ‘land-use’, and ‘the rights, powers, duties and liabilities of a legal person’. These attributes suggest something more than mere volition in self-management and protection: they suggest agency. This article explores the implications of nonhuman agency as potential for political voice. As representatives of entanglement for all being—animal (including human), vegetable and elemental—and as a matter of justice they are, perhaps, obliged to participate in democracy and the nation is, perhaps, obliged to give them a ‘seat at the table’. As political agents with equal status to human and corporate persons Te Awa Tupua, Te Urewera and Taranaki Maunga might unsettle settler politics and challenge the imbalances of the Anthropocene.
Terrain
Authors: WEIR JESSICA K. 
Published: December 2021

Abstract
Indigenous leaders and scholars demand greater respect for their governance and knowledge authority, with one priority the de/centring of the environmental management research-praxis arising out of natural science traditions (Latulippe and Klenk, 2020). That is, to de-centre colonial privilege and centre Indigenous authority. Who can do this and how involves conceptual, political and cultural expertise; yet, natural science disciplinary practices prioritise invisibilizing power, culture and perspective (Latulippe and Klenk, 2020; Vásquez-Fernández and Ahenakew, 2020). This article is an intervention into this context. As a non-Indigenous scholar, I introduce the analytical tools I use to unpack two core assumptions that confounded my ability to hear what Indigenous mentors were saying about environmental management. With two demonstrations—Xaxli’p (Canada) and Gunditjmara (Australia)—I also show how Indigenous leaders do not just present their own approaches, but re-constitute environmental management itself with their meanings, practices, and priorities, whilst environmental management also influences Indigenous knowledge and governance. My focus is with how knowledge is formed and re-formed within and between diverse knowledge holders, including my work as a reflexive modern scholar. Significantly, this article is not purely for edification: this is justice work—in support of both Indigenous people and nature.
Unreported standard errors in meta-analysis
Authors: Longford Nicholas T. 
Published: December 2021

Abstract
A study that would otherwise be eligible is commonly excluded from a meta-analysis when the standard error of its treatment-effect estimator, or the estimate of the variance of the outcomes, is not reported and cannot be recovered from the available information. This is wasteful when the estimate of the treatment effect is reported. We assess the loss of information caused by this practice and explore methods of imputation for the missing variance. The methods are illustrated on two sets of examples, one constructed specifically for illustration and another based on a published systematic review.
Approximately optimum strata boundaries for two concomitant stratification variables under proportional allocation
Authors: Danish Faizan , Rizvi S. E. H. 
Published: December 2021

Abstract
The proper choice of strata boundaries is an important factor determining the efficiency of the estimator of the considered characteristics of a population. In this article, the Cum Rule (i=3,4) for obtaining approximately optimum strata boundaries has been applied, taking into account a single-study variable along with two concomitant variables serving as the basis of the stratification variables. The relative efficiency of the proposed methods has been demonstrated theoretically and empirically by comparing them to a selection of already-existing methods in a simulation study with the use of the proportional allocation method.
Type II Topp-Leone Frechet distribution: properties and applications
Authors: Shanker Rama , Rahman Umme Habibah 
Published: December 2021

Abstract
The paper focuses on type II Topp-Leone Frechet distribution. Its properties including hazard rate function, reverse hazard rate function, Mills ratio, quantile function and order statistics have been studied. The maximum likelihood estimation used for estimating the parameters of the proposed distribution has been explained and expressions for the Fisher information matrix and confidence intervals have been provided. The paper discusses the applications of the distribution for modeling several datasets relating to temperature. Finally, the goodness of fit of the proposed distribution has been compared with that of the Frechet distribution.