bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estágio Supervisionado II no ensino fundamental: uma experiência de atividade na aula de História com uso de jogos em uma escola municipal de Ananindeua/PA
Authors: Rodrigues Eliandra Gleyce Dos Passos 
Published: March 2021

O trabalho tem como objetivo relatar a experiência vivenciada no espaço escolar, prática proporcionada pela disciplina de Estágio Supervisionado II, apresentando como resultados as principais atividades realizadas de observações, de regências e de intervenções em sala de aula. Entende-se que acompanhar a disciplina de História, no sistema público de ensino, é a forma pela qual a Universidade dialoga com o ensino da escola pública e proporciona mecanismos de preparação aos futuros professores. Através desse contato com a escola, que recebe os acadêmicos nas suas práticas de estudo, pesquisa e extensão, e de formação docente na área de História, busca-se também incentivar a promoção de metodologias experimentadas, a serem inseridas no ensino em sala de aula; como resultado deste processo de estágio é apresentado aqui a metodologia de um Quiz Histórico usado em sala de aula.Palavras-Chave: Relato de Estágio Supervisionado II; Sala de Aula; Ensino de História; Metodologia de Ensino. AbstractThis paper aims to report the experience in the school space, which was the supervised internship discipline II, presenting, as results, the main activities, observations and interventions performed in the classroom. It is understood that accompanying the discipline of History in the public school system is the way in which the University not only dialogues with the public school teaching, but also provides the mechanisms for the preparation of future teachers through contact with the school. The public school receives academics from the University for the practice of study, research and teacher education in the area of history, and encourages the promotion of methodologies to be inserted in classroom teaching. As a result of this internship process, we present here the methodology of a Historical Quiz carried out in class.Keywords: Supervised Internship Report II; Classroom; History Teaching; Teaching Methodology.
Factores de Riesgo para la Salud Sexual de Jóvenes Sordos: Evaluación con un Cuestionario Computarizado
Authors: Robles Montijo Silvia Susana , Guevara-Benítez Carmen Yolanda , Pérez-Bautista Yuma Yoaly 
Published: March 2021

El objetivo del estudio fue analizar un conjunto de factores de riesgo para la salud sexual de jóvenes mexicanos con discapacidad auditiva. Se utilizó un cuestionario computarizado con instrumentos validados y adaptados para la población sorda. En 112 jóvenes con edad promedio de 19.7 años se aplicaron los siguientes instrumentos: comunicación sexual con padres y con madres, apoyo y supervisión parental, conocimientos sobre infecciones de transmisión sexual y sobre el uso del preservativo, así como prácticas y abuso sexuales. En los jóvenes sexualmente activos se identificó un patrón de conducta sexual de riesgo, con proporciones importantes que han vivido abuso sexual. Se encontraron bajos niveles tanto en comunicación y supervisión parental, como en las pruebas de conocimientos. La comunicación con los padres se relacionó con el uso del preservativo y fue mayor en quienes no han vivido abuso sexual. En los varones sin experiencia sexual, las variables parentales se asociaron con ambas pruebas de conocimientos.

Cómo citar este artículo: Robles-Montijo, S., Guevara-Benítez, Y., & Pérez-Bautista, Y. (2021). Factores de Riesgo para la Salud Sexual de Jóvenes Sordos: Evaluación con un Cuestionario Computarizado. Revista Colombiana de Psicología, 30(1), 27-45. https://doi.org/10.15446/rcp. v29n2.77173
Clinical and Epidemiological Features of Hospitalized Patients with COVID-19 in Hospitals of Tehran University of Medical Sciences
Authors: Baigi Vali , Nedjat Saharnaz , Yunesian Masud , Akbari Sari Ali , Mirzaee Mahboobeh , Allameh Seyed Farshad 
Published: March 2021

Introduction: Since the start of COVID-19 pandemic in December 2019, until mid-April 2020 the total number of cases worldwide exceeded two millions and the death toll exceeded 130000 cases.
Objective: The current study conducted to explore the clinical and epidemiological characteristics of COVID-19 patients, fatality of this disease and its mortality risk factors in major hospitals affiliated with Tehran University of Medical Sciences (TUMS).
Methods: The data were collected in four major teaching hospitals affiliated with TUMS for all the patients that were admitted between Feb 19th and Apr 15th 2020 and were diagnosed as COVID-19 using reverse transcription polymerase chain reaction (RT-PCR), clinical diagnosis and/or lung computed tomography (CT) scan. The case fatality rate of the disease was estimated by age, sex, symptoms, comorbidities, and type of diagnosis. Logistic regression model was used to examine the associations between different factors and in-hospital deaths.
Results: By Apr 15th 2020, a total of 4377 patients were admitted with COVID-19 diagnosis in four selected hospitals and 496 (11.3%) of these patients died in hospital. The case fatality rate of this disease was 28.8% in the ≥80-year age group, which was the highest compared to the other age groups. The case fatality rates were 12.5% and 9.8% among men and women, respectively. The results of multiple logistic regression on the outcome of death indicated that age, sex, cough, myalgia, reduced consciousness at arrival and past history of cancer were significantly associated with in-hospital death. Adjusting the effect of other variables, for each 10-year increase in age, the odds of death due to COVID-19 was 1.61 times greater (adjusted OR 1.61, 95% CI: 1.51 to 1.72, p<0.001).
Conclusions: Older age, the male gender, past history of comorbidities (particularly cancer) and reduced consciousness at arrival are among the factors that can significantly increase the odds of in-hospital death in COVID 19 patients. These factors might be helpful in detecting and managing patients with poorer prognosis.
An Incidental Finding of a Double-Lumen Trachea
Authors: Piersiala Krzysztof , Loroch Anna , Jackowska Joanna , Wierzbicka Malgorzata 
Published: March 2021

The aim of this case report is to present an incidental finding of a firm tracheal septum in a 61-year-old woman. The patient was admitted to the hospital with mild dyspnea and a preliminary diagnosis of a tracheal subglottic stenosis. During microlaryngoscopy, just below the subglottic stenosis, a firm, vertical symphysis (septum), forming a double-lumen trachea was found. There was no record of any previous difficulties with intubation. A computed tomography scan performed after the microlaryngoscopy revealed an airway branch arising from the trachea at the level of thyroid gland and joining its lumen below. The radiological and endoscopic findings in the presented case hardly resemble the conditions described in the literature, as the discovered septum does not have a pseudomembranous nature, nor does it form a tracheal bronchus. Therefore, the finding is thought to be an unusual complication of multiple intubations in the past. This is an extremely rare finding and it is important to share our experience in managing a patient with the aforementioned post-intubation complications.
Chronic Expanding Hematomas That Occurred 20 Years or More After Primary Total Hip Arthroplasty
Authors: Ishikawa Tomomi , Kawai Toshiyuki , Goda Naoki , Goto Koji , Kuroda Yutaka , Matsuda Shuichi 
Published: March 2021

Case:
We report 2 patients who developed chronic expanding hematomas (CEHs) more than 20 years after ceramic-on-polyethylene total hip arthroplasty (THA). One CEH occurred after a minor fall, and the other appeared with no obvious injury. Neither of the 2 was on anticoagulation. Each caused extensive osteolysis.

Conclusion:
The only 2 previously reported post-THA cases of CEH involved metal-on-metal THAs and occurred several years after the index THA. Our patients show that CEH also can occur after ceramic-on-polyethylene THA, even after an uneventful clinical course of more than 20 years. Complete removal of both hematoma stopped osteolytic progression, with no recurrence to date.
Assessment of the YKL-40 concentration in patients with tick-borne encephalitis
Authors: Czupryna Piotr , Kulczyńska-Przybik Agnieszka , Mroczko Barbara , Wondim Mulugeta , Grygorczuk Sambor , Borawski Karol , Pancewicz Sławomir , Moniuszko-Malinowska Anna 
Published: March 2021

Abstract
Background
Tick-Borne Encephalitis (TBE) is a viral infection of the Central Nervous System (CNS) caused by Tick-Borne Encephalitis Virus (TBEV). It might take several clinical courses such as: meningitis, meningoencephalitis or meningoencephalomyelitis. The aim this study was to compare the YKL-40 concentration in cerebrospinal fluid (CSF) of patients with different clinical presentations of TBE and patients with excluded meningitis (control group).
Methods
The concentration of YKL-40 in CSF was determined using Fujirebio tests (Ghent, Belgium) in 32 patients with TBE: group I—patients with meningoencephalitis (n = 16); group II—patients with meningitis (n = 16). The control group (CG) consisted of 17 patients in whom inflammatory process in central nervous system was excluded.
Results
The concentration of YKL-40 was significantly higher in encephalitis group than in CG after 7 days from the last dose of treatment. The concentration in patients with neuroinflammation had significantly different concentration of YKL-40 compared to patients with no neuroinflammation control groups. ROC curve analysis indicates that: CSF YKL-40 concentration at cut off 783.87 differentiated TBE patients from CG with 100% specificity and 70% sensitivity and CSF YKL-40 concentration at cut off 980.11 differentiated meningitis from meningoencephalitis with 87.5% specificity and 62.5% sensitivity.
Conclusions
YKL-40 takes part in TBE pathogenesis, its concentration is the highest at the early stage of Central Nervous System involvement and decreases in the convalescent period. As YKL-40 is significantly higher in meningitis than in meningoencephalitis, it might be used as biomarker in differentiation of these clinical forms of TBE.
Epidemiology of Sepsis-associated Acute Kidney Injury in Beijing, China : a descriptive analysis
Authors: Wang Haiman , Ji Xiaojun , Wang Amanda Y , Wu Patrick , Liu Zhuang , Dong Lei , Liu Jingfeng , Liu Pei , Qi Zhili , Duan Meili 
Published: March 2021

Abstract
Background Sepsis is the most common contributing factor towards development of acute kidney injury (AKI), which is strongly associated to poor prognostic outcomes. There are numerous epidemiological studies about sepsis-associated acute kidney injury (S-AKI), however current literature is limited with the majority of studies being conducted only in the intensive care unit (ICU) setting. The aim of this study was to assess the epidemiology of S-AKI in all hospitalized in-patients.Methods This was a retrospective population-based study using a large regional population database in Beijing city from January, 2005 to December, 2017. It included patients with S-AKI. Patients with pre-existing end-stage kidney disease (ESKD), previous history of kidney transplantation, or being pregnant were excluded. Patients’ demographic characteristics, incidence, risk factors and outcomes of S-AKI were analyzed. The differences between different time periods, different levels of hospitals, and types of the hospitals (i.e. traditional Chinese medicine hospitals (TCMHs) and Western medicine hospitals (WMHs)) were also compared using Mann-Whitney U test.Results A total of 19,579 patients were included. The overall incidence of S-AKI in all in-patients was 48.1%. The risk factors for AKI included: age (P < 0.001), male (P < 0.001), treatment in a level-II hospital (P < 0.001) and so on. The overall mortality rate in this cohort was 55%. The risk factors for mortality included: age (P < 0.001), female (P < 0.001), pre-existing chronic kidney disease (CKD) (P = 0.023) and so on. The incidence of S-AKI increased over time, but the mortality rate did not. Compared with level-II hospitals, the incidence of S-AKI was similar in tertiary hospitals, but the mortality rate was significantly higher.Although patients treated in TCMHs had a shorter hospital stay and a lower cost of care, this cohort had a higher mortality rate when compared with patients treated in WMHs.Conclusions AKI is a common complication in all hospitalized patients with sepsis, and its incidence increases over time, especially when ICU admission is required. Exploring interventional strategies to address modifiable risk factors will be important to reduce incidence and mortality of S-AKI.
Identification of novel potential biomarkers in hepatocarcinoma cancer; a transcriptome analysis
Authors: kakar Mohib , Mehboob Muhammad , Akram Muhammad , Iqbal Imran , Ijaz Hafza , Aziz Ubair , Lodhi Adil , Rasheed Madiha , Deng Yulin , Dai Rongji 
Published: March 2021

Abstract
Objective

The goal of this study was to understand possible core genes associated with hepatocellular carcinoma (HCC) pathogenesis and prognosis.
Methods

GEO contains datasets of gene expression, miRNA and methylation patterns of diseased and healthy/control patients. GSE62232 Dataset was selected by employing the server Gene Expression Omnibus. A total of 91 samples were collected, including 81 HCC samples and 10 healthy samples as control. GSE62232 was analyzed through GEO2R, and Functional Enrichment Analysis was performed to extract rational information from a set of DEGs. The Protein-Protein Relationship Networking search method has been used for extracting genes interacting. MCC method was used to calculate the top 10 genes according to their importance. Hub genes in the network were analyzed using GEPIA to estimate the effect of their differential expression on cancer progression.
Results

We identified the top 10 hub genes through Cytohubba plugin. These genes include Cell Cycle Regulatory Cyclins and Cyclin-dependent proteins CCNA2, CCNB1 and CDK1. The pathogenesis and prognosis of HCC may be directly linked with the aforementioned genes.
Conclusion

In this analysis, we found critical genes for HCC that showed recommendations for more diagnostic and predictive biomarkers studies that could promote selective molecular therapy for HCC.
Identification of a nine ferroptosis-related lncRNA prognostic signature for lung adenocarcinoma
Authors: Tong Xiwen , Zhang Yujiao , Yang Guodong , Yi Guanghui 
Published: March 2021

Abstract
Background: Recently, mounting of studies has shown that lncRNA affects tumor progression through the regulation of ferroptosis. The current study aims to construct a robust ferroptosis-related lncRNAs signature to increase the predicted value of lung adenocarcinoma (LUAD) by bioinformatics analysis. Methods: The transcriptome data were abstracted from The Cancer Genome Atlas (TCGA). Differentially expressed lncRNAs were screened by comparing 535 LAUD tissues with 59 adjacent non-LAUD tissues. Univariate Cox regression, lasso regression, multivariate Cox regression were conducted to design a ferroptosis-related lncRNA signature. This signature’s prognosis was verified by the log-rank test of Kaplan-Meier curve and the area under curve (AUC) of receiver operating characteristic (ROC) in train set, test set, and entire set. Furthermore, univariate and multivariate Cox regression were used to analyze its independent prognostic ability. The relationship of the ferroptosis-linked lncRNAs' expression and clinical variables was demonstrated by Wilcoxon rank-sum test and Kruskal-Wallis test. Gene set enrichment analysis (GSEA) was performed to signaling pathways it may involve.Results: 1224 differentially expressed lncRNAs were identified, of which 195 are ferroptosis-related lncRNAs. A nine ferroptosis-related lncRNAs (AC099850.3, NAALADL2-AS2, AL844908.1, AL365181.2, SMIM25, FAM83A-AS1, LINC01116, AL049836.1, C20orf197) prognostic signature was constructed. This model's prognosis in the high-risk group is obviously worse than that of the low-risk group in train set, test set, and entire set. The AUC of ROC predicting the three years survival in the train set, test set, and entire set was 0.754, 0.716, and 0.738, respectively. Moreover, the designed molecular signature was found to be an independent prognostic variable. The expression of these lncRNAs and the lncRNA signature are related to clinical stage, T stage, Lymph-node status, distant metastasis. Finally, GSEA analysis results show that the signature is involved in eight tumor-related and metabolism-related signaling pathwaysConclusion: The current study constructed, validated, and evaluated a nine ferroptosis-related lncRNA signature which can independently be used to predict the prognosis of LAUD patients, and may become a new therapeutic target.
Per- and polyfluoroalkyl substances in groundwater of Thailand: Occurrence, source identification and spatial distribution
Authors: Hongkachok Chanidaporn , Boontanon Suwanna , Boontanon Narin , Sukeesarn Suratsawadee , Polprasert Chongrak , Fujii Shigeo 
Published: March 2021

Abstract
Per- and polyfluoroalkyl (PFAS) have the potential to leach down to the groundwater particularly in areas with potential source pollution such as landfills. The composition patterns of PFAS, distribution and soil characteristics significantly contribute to their source identification. The objectives of this study were: (1) to examine the levels of PFAS in Thailand groundwater, (2) to identify potential sources, and (3) to study the spatial distribution of PFAS. Groundwater samples were collected around municipal waste disposal sites (MWDS) and industrial waste disposal sites (IWDS). Seven PFAS were extracted by solid phase extraction technique and analyzed by high-performance liquid chromatography tandem mass spectrometer. Total PFAS in groundwater around the MWDSs varied from 1.68 to 7.75 ng L− 1. The total PFAS in groundwater around the IWDS varied from 2.64 to 42.01 ng L− 1. PFOA and PFOS were the most dominant compounds around the MWDS and IWDS areas. PFHxS was frequently observed in the groundwater around the IWDSs, suggesting that it has been used as a substitution of PFOS-based compounds due to it having a shorter chain length or resulting from degradation of fluorotelomers. In addition to source identification, the hierarchical cluster analysis showed that other than the waste disposal site, other factors or activities could have been involved. It was found that livestock farming and an abandoned pond very close to the groundwater well could have affected the levels of PFAS in the groundwater. Moreover, spatial distribution showed that besides the impact of waste sources, soil characteristics and interaction between negative charged PFAS and cation in the soil played an important role in the PFAS contamination in groundwater.
The gut microbiome of 7-37 month old children from The Gambia shows the development of a distinct non-industrial Prevotella-based trophic network
Authors: de Goffau Marcus , Jallow Amadou , Sanyang Chilel , Prentice Andrew , Parkhill Julian , Pereira Dora , Wagner Josef 
Published: March 2021

Abstract
Distinctive bacterial trophic networks exist in the gut microbiota of individuals in industrialized and non- industrialized countries. To study the development of these networks, we investigated the gut microbiota of 7-37 month old children living in rural Gambia (616 children, 1407 stool samples, stratified by 3-month age groups). We found that child age was the largest discriminating factor between samples, and that anthropometric indices WAZ, HAZ, and WHZ, collection timepoints, and iron supplementation did not significantly influence the gut microbiome in this data set. Prevotella copri, Faecalibacterium prausnitzii, and Prevotella stercorea were the most abundant species (35%, 11%, and 7%, respectively). Distinct bacterial trophic network clusters were identified, centered around Prevotella stercorea and Faecalibacterium prausnitzii, which were found to develop steadily as the gut microbiome matured. The Prevotella stercorea trophic network cluster is distinct from those found in individuals in industrialized countries and therefore this dataset, set within a critical developmental timeframe, provides an excellent opportunity to understand the influence of a high fiber, low-protein diet on the development of a Prevotella-enriched gut microbiome.
Disentangling race, environment and the microbiome in a study of preterm birth risk
Authors: Sun Shan , Serrano Myrna , Fettweis Jennifer , Basta Patricia , Rosen Emma , Ludwig Kim , Sorgen Alicia , Blakley Ivory , Wu Michael , Dole Nancy , Thorp John , Siega-Riz Anna , Buck Gregory , Fodor Anthony , Engel Stephanie 
Published: March 2021

Abstract
Previous studies have investigated the associations between the vaginal microbiome and preterm birth (PTB), with the aim of determining whether differences in community patterns meaningfully alter risk, and could therefore be the target of intervention. We report on vaginal microbial analysis on a subset of the Pregnancy, Infection, and Nutrition (PIN) Study, a prospectively enrolled cohort of women in central North Carolina between 1995-2001. We selected a nested case-control subset of this cohort, including 464 White women (375 term birth and 89 spontaneous PTB, sPTB) and 360 Black women (276 term birth and 84 sPTB). Microbial DNA was extracted from genital track swabs collected mid-pregnancy, and subjected to 16S rRNA taxonomic profiling. We found that microbial community structure is associated with race and sPTB, although the influence of race is stronger than the influence of sPTB. The microbiome of Black women has higher alpha-diversity, higher abundance of Lactobacillus iners and lower abundance of Lactobacillus crispatus. These differences were obscured once maternal douching behavior was considered—specifically, among women who douche, there were no significant differences in microbiome by race. The sPTB associated microbiome exhibited a lower abundance of L. crispatus, while alpha diversity and L. iners were not significantly different. Associations between the microbiome and sPTB were only significant in women who do not douche. While race was a strong predictor of microbial community structure, we also observed strong intercorrelations between a range of maternal factors, including poverty, education, marital status, age, douching and race, with microbiome effect sizes in the range of 1.8-5.2% in univariate models. Therefore, race may simply be a proxy for other socially driven factors that differentiate microbiome community structures. Future work will continue to refine reliable microbial biomarkers for preterm birth across diverse cohorts.
Preparation of Zinc(II) Phthalocyanine-Based LB Thin Film: Experimental Characterization, the Determination of Optical Properties and Harmful Organic Vapor Sensing Ability
Authors: Acikbas Yaser , Erdogan Matem , Capan Rifat , Ozkaya Cansu , Baygu Yasemin , Kabay Nilgün , Gök Yaşar 
Published: March 2021

Abstract
Zinc(II) phthalocyanine (Zn(II)Pc) molecule was the first time prepared onto three different substrates utilizing Langmuir-Blodgett (LB) deposition technique to investigate its vapor sensing abilities and some optical properties. We utilized five different and well-known techniques to control monolayer quality of Zn(II)Pc LB film. The obtained the thickness and refractive index values for Zn(II)Pc LB film with coated at different layers vary from 3.2 to 10.9 nm and from 1.42 to 1.71, respectively. The sensing properties were investigated by exposing the Zn(II)Pc-based mass or optical sensor to some organic vapors. Kinetic results presented that this Zn(II)Pc material is a good candidate as a sensor element with a fast and reversible response for dichloromethane sensing devices.