bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cooling Improves Cosmic Microwave Background Map-making when Low-frequency Noise is Large
Authors: Chiang 强 Bai-Chiang 百强 , Huffenberger Kevin M. 
Published: November 2021

Abstract
In the context of cosmic microwave background data analysis, we study the solution to the equation that transforms scanning data into a map. As originally suggested in “messenger” methods for solving linear systems, we split the noise covariance into uniform and nonuniform parts and adjust their relative weights during the iterative solution. With simulations, we study mock instrumental data with different noise properties, and find that this “cooling” or perturbative approach is particularly effective when there is significant low-frequency noise in the timestream. In such cases, a conjugate gradient algorithm applied to this modified system converges faster and to a higher fidelity solution than the standard conjugate gradient approach. We give an analytic estimate for the parameter that controls how gradually the linear system should change during the course of the solution.
PHANGS–ALMA: Arcsecond CO(2–1) Imaging of Nearby Star-forming Galaxies
Authors: Leroy Adam K. , Schinnerer Eva , Hughes Annie , Rosolowsky Erik , Pety Jérôme , Schruba Andreas , Usero Antonio , Blanc Guillermo A. , Chevance Mélanie , Emsellem Eric , Faesi Christopher M. , Herrera Cinthya N. , Liu Daizhong , Meidt Sharon E. , Querejeta Miguel , Saito Toshiki , Sandstrom Karin M. , Sun 孙 Jiayi 嘉 懿 , Williams Thomas G. , Anand Gagandeep S. , Barnes Ashley T. , Behrens Erica A. , Belfiore Francesco , Benincasa Samantha M. , Bešlić Ivana , Bigiel Frank , Bolatto Alberto D. , den Brok Jakob S. , Cao Yixian , Chandar Rupali , Chastenet Jérémy , Chiang 江 I-Da 宜 達 , Congiu Enrico , Dale Daniel A. , Deger Sinan , Eibensteiner Cosima , Egorov Oleg V. , García-Rodríguez Axel , Glover Simon C. O. , Grasha Kathryn , Henshaw Jonathan D. , Ho I-Ting , Kepley Amanda A. , Kim Jaeyeon , Klessen Ralf S. , Kreckel Kathryn , Koch Eric W. , Kruijssen J. M. Diederik , Larson Kirsten L. , Lee Janice C. , Lopez Laura A. , Machado Josh , Mayker Ness , McElroy Rebecca , Murphy Eric J. , Ostriker Eve C. , Pan Hsi-An , Pessa Ismael , Puschnig Johannes , Razza Alessandro , Sánchez-Blázquez Patricia , Santoro Francesco , Sardone Amy , Scheuermann Fabian , Sliwa Kazimierz , Sormani Mattia C. , Stuber Sophia K. , Thilker David A. , Turner Jordan A. , Utomo Dyas , Watkins Elizabeth J. , Whitmore Bradley 
Published: November 2021

Abstract
We present PHANGS–ALMA, the first survey to map CO J = 2 → 1 line emission at ∼1″ ∼100 pc spatial resolution from a representative sample of 90 nearby (d ≲ 20 Mpc) galaxies that lie on or near the z = 0 “main sequence” of star-forming galaxies. CO line emission traces the bulk distribution of molecular gas, which is the cold, star-forming phase of the interstellar medium. At the resolution achieved by PHANGS–ALMA, each beam reaches the size of a typical individual giant molecular cloud, so that these data can be used to measure the demographics, life cycle, and physical state of molecular clouds across the population of galaxies where the majority of stars form at z = 0. This paper describes the scientific motivation and background for the survey, sample selection, global properties of the targets, Atacama Large Millimeter/submillimeter Array (ALMA) observations, and characteristics of the delivered data and derived data products. As the ALMA sample serves as the parent sample for parallel surveys with MUSE on the Very Large Telescope, the Hubble Space Telescope, AstroSat, the Very Large Array, and other facilities, we include a detailed discussion of the sample selection. We detail the estimation of galaxy mass, size, star formation rate, CO luminosity, and other properties, compare estimates using different systems and provide best-estimate integrated measurements for each target. We also report the design and execution of the ALMA observations, which combine a Cycle 5 Large Program, a series of smaller programs, and archival observations. Finally, we present the first 1″ resolution atlas of CO emission from nearby galaxies and describe the properties and contents of the first PHANGS–ALMA public data release.
The Evaluation of Methylated Septin 9 in Blood Plasma and Tissue Biopsies for the Early Detection for Asymptomatic Colon Cancer
Authors: Kassid Ahmed Ageeb , Abdul-Rasheed Omar F. , AlKhalidy Nawal Mehdi 
Published: November 2021

The purpose of this study was to assess the utility of the SEPT9 genetic marker in the early detection of colon cancer patients. A case-control study was conducted on forty newly diagnosed colon cancer patients. The study was done between March 2019 and January 2020, patients from the Gastroenterology and Liver Education Hospital, Al-imamain Al-Kadhimain Medical City, and Baghdad Teaching Hospital were recruited. Colon cancer patients' mean age ± standard deviation was 54.4 ± 10.79 years while the age ± standard deviation of the mean of the control group was 55.1±8.54 years. For septin9 tissue methylation of the controls was done on the non-malignant tissues of the same patients.
This study concluded that the percentage of Septin 9 (SEPT9) in the tissue of patients with colon cancer (CC) was the highest value, which is more significant than that of the serum of CC patients. Both of these groups were significantly higher than the percentage of SEPT9 methylation of control tissue and serum.
Non-significant differences were obtained in the levels of CEA and CA19-9 between CC patients and controls.
The Effect of Uncaria gambir Roxb. Extract on Superoxide Dismutase Activity in Proteinuric Wistar Rats Model
Authors: Siregar Rosmayanti Syafriani , Lelo Aznan , Harris Delyuzar , Ramayani Oke Rina , Ichwan Muhammad 
Published: November 2021

Nephrotic syndrome (NS) is a glomerular disease that is most often found in children with proteinuric as clinical manifestation. Gambier extract is a traditional medicine that has antioxidant effect. Its use to treat proteinuric has never been done. Therefore, we conducted an analytical study on the effect of gambier on proteinuric and superoxide dismutase (SOD) activity in proteinuric Wistar rat’s model. This research is an experimental study with a posttest control group design. The aim is analyzing the effect of giving gambier extract in decreasing urinary protein creatinine ratio and increasing SOD activity. Male Wistar rats were given an injection of puromycin aminonucleoside 1.5mg/100g body weight (BW), subcutaneously for 5 consecutive days for being nephrosis. The experimental animals in this study were divided into four groups: K1, the control group, consist of group of rats that were injected with 0.15ml/100 g BW of aquabidest and not given gambier extract. While K2 group consist of rats induced by Puromycin and given 1 ml of aquabidest. K3 consist of groups of rats induced by Puromycin and then given gambier extract 26mg/200g BW. Group K4 consist of rats induced by Puromycin and then given 80mg/200g BW of gambier extract. The four groups were given treatment for 14 days, after which the rats were placed in a metabolic cage for 24 hours to collect urine samples and then knocked down with ketamine for intra-cardiac blood collection. The results of this study showed differences between the four groups of rats in terms of the mean urine protein/creatinine ratio (p=0.015) and SOD activity (p=0.036). Groups of rats that were given gambier extracts 80mg/200g BW had lower urine protein / creatinine ratio and higher SOD activity. Therapy of gambier 80 mg/200g BW is better in managing proteinuric compared to 26mg/200g.
Protocolo para el uso de vehículos aéreos no tripulados en la inspección de edificios agroindustriales
Authors: Gómez Javier , Tascón Alberto 
Published: November 2021

Los vehículos aéreos no tripulados, comúnmente denominados drones, son una tecnología con muchas aplicaciones potenciales en la construcción. Entre las más evidentes está la inspección de edificios durante las fases de construcción y puesta en servicio o como parte de su programa de mantenimiento. Los drones también pueden combinarse con la termografía para realizar evaluaciones energéticas. Este trabajo presenta un protocolo para la inspección de edificios agroindustriales formado por 5 fases, cada una constituida por diversas tareas. El protocolo se desarrolló a partir de experiencias previas reportadas en otros sectores, regulaciones existentes y la propia experiencia de los autores. Además, se ha validado mediante su aplicación a un caso real: una nave climatizada para crianza de vino de 7.200 m2 recién construida. La inspección proporcionó información gráfica de utilidad, tanto visible como infrarroja, y se detectaron dificultades, aspectos a considerar y precauciones para el uso de estas tecnologías.
Stereotypic Expansion of T Regulatory and Th17 Cells during Infancy Is Disrupted by HIV Exposure and Gut Epithelial Damage
Authors: Dzanibe Sonwabile , Lennard Katie , Kiravu Agano , Seabrook Melanie S S , Alinde Berenice , Holmes Susan P , Blish Catherine A , Jaspan Heather B , Gray Clive M 
Published: November 2021

Abstract
Few studies have investigated immune cell ontogeny throughout the neonatal and early pediatric period, when there is often increased vulnerability to infections. In this study, we evaluated the dynamics of two critical T cell populations, T regulatory (Treg) cells and Th17 cells, over the first 36 wk of human life. First, we observed distinct CD4+ T cells phenotypes between cord blood and peripheral blood, collected within 12 h of birth, showing that cord blood is not a surrogate for newborn blood. Second, both Treg and Th17 cells expanded in a synchronous fashion over 36 wk of life. However, comparing infants exposed to HIV in utero, but remaining uninfected, with HIV-unexposed uninfected control infants, there was a lower frequency of peripheral blood Treg cells at birth, resulting in a delayed expansion, and then declining again at 36 wk. Focusing on birth events, we found that Treg cells coexpressing CCR4 and α4β7 inversely correlated with plasma concentrations of CCL17 (the ligand for CCR4) and intestinal fatty acid binding protein, IL-7, and CCL20. This was in contrast with Th17 cells, which showed a positive association with these plasma analytes. Thus, despite the stereotypic expansion of both cell subsets over the first few months of life, there was a disruption in the balance of Th17 to Treg cells at birth likely being a result of gut damage and homing of newborn Treg cells from the blood circulation to the gut.
CD8+ T Cells Expressing an HLA-DR1 Chimeric Antigen Receptor Target Autoimmune CD4+ T Cells in an Antigen-Specific Manner and Inhibit the Development of Autoimmune Arthritis
Authors: Whittington Karen B , Prislovsky Amanda , Beaty Jacob , Albritton Lorraine , Radic Marko , Rosloniec Edward F 
Published: November 2021

Abstract
Ag-specific immunotherapy is a long-term goal for the treatment of autoimmune diseases; however developing a means of therapeutically targeting autoimmune T cells in an Ag-specific manner has been difficult. Through the engineering of an HLA-DR1 chimeric Ag receptor (CAR), we have produced CD8+ CAR T cells that target CD4+ T cells in an Ag-specific manner and tested their ability to inhibit the development of autoimmune arthritis in a mouse model. The DR1 CAR molecule was engineered to contain CD3ζ activation and CD28 signaling domains and a covalently linked autoantigenic peptide from type II collagen (CII; DR1-CII) to provide specificity for targeting the autoimmune T cells. Stimulation of the DR1-CII CAR T cells by an anti-DR Ab induced cytokine production, indicating that the DR1-CAR functions as a chimeric molecule. In vitro CTL assays using cloned CD4+ T cells as target cells demonstrated that the DR1-CII CAR T cells efficiently recognize and kill CD4+ T cells that are specific for the CII autoantigen. The CTL function was highly specific, as no killing was observed using DR1-restricted CD4+ T cells that recognize other Ags. When B6.DR1 mice, in which autoimmune arthritis had been induced, were treated with the DR1-CII CAR T cells, the CII-specific autoimmune CD4+ T cell response was significantly decreased, autoantibody production was suppressed, and the incidence and severity of the autoimmune arthritis was diminished. These data demonstrate that HLA-DR CAR T cells have the potential to provide a highly specific therapeutic approach for the treatment of autoimmune disease.
Bioaccumulation of auto-mechanic wastes in the tissues of Pellonula Afzeliusi (Johnels, 1954) collected from Agba stream Ilorin, Kwara State, Nigeria
Authors: Adeyemi-Ale O. A. , Oladipo S. O. , Abdulkareem S. I. 
Published: November 2021

Hydrocarbons and heavy metals (HM) present in automobile wastes get into water bodies close to automobile mechanic villages. They deteriorate the physico-chemical qualities of such water bodies and exert toxic effects on fish and other aquatic fauna. They also pose risks to humans that consume fish from streams near such automechanic villages. There is paucity of information on the HM contents of Agba stream, Ilorin and no information on the bioaccumulation of HM in the tissues of Pellonula afzeliusi is currently available. The purpose of this study was to assess the physico-chemical qualities of water and bioaccumulation of HM in the tissues of Pellonula afzeliusi fish collected from Agba stream, Ilorin, Kwara State, Nigeria. Water and samples of Pellonula afzeliusi were collected from the upstream (station A), midstream (station B) of Agba stream located close to an auto-mechanic village and Oyun dam (control site, station C) located within the University of Ilorin. Standard methods were used to analyse oil and grease (OG), total petroleum hydrocarbon (TPH) and HM in water samples. The concentrations of TPH and HM were analysed in the skin, bone, muscle, gills, gastrointestinal tract, liver and kidney of the fish. The order of water HM concentrations indicated Zn > Cd > Ba> Fe > Pb at station A; Cd > Zn > Fe > Ba > Pb at station B, and Zn > Ba > Pb > Fe >Cd at station C. TPH and HM bioaccumulated in the tissues of fish while lead was not detected in all tissues from station C. Bioaccumulation factor varied with the highest values t station C. The result of this study indicated heavy pollution burden in station B with lower pollution burden in station C (the control site). These call for attention of government in ensuring ecological restoration and prevention of further discharge of automobile wastes into the stream.
Keywords: Automobile wastes, Heavy metals, Hydrocarbons, Bioaccumulation, Pellonula afzeliusi
Metagenomic tracking of microbial consortia of cassava flakes (garri)
Authors: Thomas B.T. , Efuntoye M.O. , Kolawole R.M. , Popoola O.D. , Tajudeen A.O. 
Published: November 2021

The affirmation of several cross-sectional studies on the vulnerability of cassava flakes commonly called 'garri' to microbial attack has long been documented. However, longitudinal data on metagenomic tracking of microbial consortia of this important staple food are scarce. Hence, this study was aimed at tracking the microbial consortia of garri. A total of eight samples (four each from both Nigeria and Republic of Benin markets) were randomly collected aseptically using pre-sterilized aluminum pans and processed through a metagenomic approach, while both the chemical and proximate components of garri were assessed following standard techniques. The analysis of the taxonomic consortia of garri reveals the predomination of bacteria (99.82 and 99.81% for samples from Nigeria and Republic of Benin, respectively) while the remaining sequences matched with the Archae (0.07%), fungi (0.09%) and protozoa (0.09%). A large proportion of the sequences were unclassified at the phylum level (approximately 84.10 and 86.2% for Nigerian and Beninese samples, respectively). The reads of cassava flakes metagenome of both Nigeria and Republic of Benin exhibited analogous level of average GC content with sequence count of between 187773-213444 for samples from Nigeria and 157784-198763 for samples from Republic of Benin. The functional characteristics of the inhabiting metagenomes were found containing the genes encoding for adhesins, bacteriocins, resistance to antibiotics, toxic chemicals as well as toxins and superantigens. Both the chemical and the proximate compositions of the examined garri samples, though exhibited significant disparity, but without any apparent variation in the patterns of metagenomic data. Our findings however revealed bacteria as the major contaminants of these cassava food products.
Keywords; Metagenomics, Microorganisms, Cassava flakes (garri), Proximate composition
Impact of Social Determinants of Health on Chronic Kidney Disease: A Review of Disparities in Renal Transplantation
Authors: Lombardi Conner , Glosser Logan , Knauss Hanna , Norwood Teanya , Berry Julia , Ekwenna Obinna 
Published: November 2021

Background: Striking disparity exists in the incidence and treatment of chronic kidney disease (CKD) secondary to individual social determinants of health. Additionally, the uninsured, minority racial-ethnic groups, and Medicaid enrollees receive less nephrology care prior to being diagnosed with end-stage renal disease (ESRD). The most effective treatment for the management of kidney failure is kidney transplantation. This review addresses how social determinants of health impact the workup for patients with ESRD, with emphasis on the kidney transplant process.

Methods: A search was conducted via multiple online databases (MedLine, PubMed, etc.) for articles that addressed the interplay between CKD, ESRD and kidney transplantation with the social determinants of health.

Findings: The impact of the social determinants of health on CKD, ESRD, and the kidney transplantation process can be qualitatively and quantitatively measured using the five categories of education, health care and access, economic stability, neighborhood and built environment, and social and community context.

Conclusion: Social determinants of health impact outcomes in CKD, ESRD, and kidney transplantation. Public and private initiatives aimed at reducing social disparities among patients with kidney disease must include emphasis on education, health care and access, economic stability, neighborhood and built environment, and social and community context. This initiative is necessary to prevent progression to ESRD and to ensure quality care in the kidney transplantation process.
Digital transformation of the educational and methodological support of the railway university
Authors: Boikov E. V. , Orlenko A. I. , Domnin S. V. 
Published: November 2021

A full-fledged transformation is impossible without the use of new didactic approaches and without the creation of a qualitatively new educational and methodological support. This is due to the peculiarities of the modern student. Modern students were born and grew up in an information-saturated world and they are dominated by clip thinking, which is focused on processing information in short portions. Based on this, the problem of developing such training programs that would be aimed at independent work, based on game methods of presenting information, would take into account the psychophysiological features of perception, processing and storage of information by a modern person becomes urgent.To solve this problem, the authors analyzed the results of cognitive psychology research, conducted a self-analysis of the experience of developing and implementing three-dimensional interactive training programs in the educational process.The paper reveals the problems and disadvantages of traditional ways of presenting information. Examples of the implementation of interactive training applications are shown. The method of organizing a distributed distance learning system is presented.The conducted research allowed us to outline ways to modernize educational and methodological support by using interactive applications, mobile learning, resource allocation, introduction of modern digital solutions and creation of a comfortable educational environment.
A Comparative Clinical Study in the Management of Vataja Kasa w.s.r. to Tropical Pulmonary Eosinophilia by Shringarabhra Rasa and Shwasakasa Chintamani along with Mridu Virechana
Authors: Sourabh Gupta  , Sridevi. P. Kulkarni  
Published: November 2021

Vataja kasa vis-à-vis T.P.E is a disease of Swasanavaha samsthana, is one of the commonest problem in tropical countries like India. India being a tropical country the prevalence of TPE is remarkable. Vatajakasa presents with symptoms like Shuska kasa, Prasakta vega, Uraha shoola, Ksheena bala, Ksheena oja, Kshamana etc. In Ayurveda, researches have been done and Vataja kasa can be compared with TPE. TPE symptoms such as repeated bouts of dry cough, chest pain, weight loss, and Malaise etc may continue for weeks or months with remission and reoccurrence.
Methods: Classical signs and symptoms of Vataja kasa and raised esinophil count >500cells/cumm and 30 patients were selected and randomly allocated in two groups. Firstly, Shunti churna with hot water was given for Amapachana, later patients were given Kantakari ghrita for Snehapana prior to Virechana with Eranda taila in both the groups followed by Shringarabhra rasa in Group A and Shwasa kasa chintamani in Group B for 21 days with follow up of 1 month.
Results: Both Group A and Group B provided highly significant results in all parameters of assessment but group B showed better improvement in the symptoms of the disease Vataja kasa in the present study.
Interpretation and Conclusion: 15 subjects (50%) got marked relief, 5 subjects (16.66%) got moderate relief in subjective parameters; 20 subjects (66.66%) got mild relief and 5 (16.66%) subjects got moderate relief in objective parameter. Hence, the modalities of our treatment can be recommended to all the patients of Vataja kasa without any hesitation.
Analisis Profitabilitas Perusahaan Kompas 100 Sebelum dan Saat Pandemi Covid-19
Authors: Evany Sherfina Tabatini , Rinofah Risal , Prima Sari Pristin 
Published: November 2021

This study aims to find out how significant the difference caused by the covid-19 pandemic is on the Profitability (ROA,ROE,NPM) of the Kompas 100 company.In this research, using descriptive comparative with quantitative approach and using secondary data. The population includes companies listed on the Kompas 100 index on the Indonesia Stock Exchange, then selected using purposive sampling technique, obtained a total of 46 companies that meet the criteria. The profitability uses (ROA, ROE, NPM). Then the ratio was tested differently using the Wilcoxon sign rank test with the help of SPSS 22.The results showed that there was a significant difference in profitability ratios which included ROA, ROE and NPM at the Kompas 100 company between the period before and during the covid-19 pandemic.
Keywords: Profitability, ROA, ROE , NPM