bluuebunny/crossref_metadata_2025_split huggingface dataset:
NPD accounting: unveiling the potential through pragmatic constructivism
Authors: Laine Teemu , Suomala Petri , Nørreklit Hanne 
Published: June 2021

This paper examines the potential value of accounting for the NPD managers and argues that accounting information could play a more versatile role in supporting managerial work in NPD that has been reported. Besides providing facts, accounting may help managers identify their possibilities and communicate their values and valuations, which is to benefit the aims of product development process.The paper draws from the idea that the roles of accounting vary under different types of uncertainties present in NPD processes. Especially, other roles than that of an “answer machine” are favored. To investigate this, the approach of pragmatic constructivism is employed, i.e., we analyze NPD accounting through facts, possibilities, values and communication related to NPD management. Empirically, the paper is based on 28 interviewees in 10 companies with significant NPD activities to explore the roles of NPD accounting and compare the potential value of accounting to the accounting employment of the examined companies.From the perspective of pragmatic constructivism, the role of accounting should be clearly related to the analyses and communication of the possibilities and their values (ammunition device, learning device and rationalization device). If this was the case, accounting would be able to serve as an integrative device, which helps to identify (construct) causalities. However, the actual role given to accounting and identified by the managers is that of the provider of the seemingly objective economic facts (answer machine). Besides, the paper reports some best practices, where the managers either have started to actively identify learning opportunities from past projects through accounting information (“a learning theory of truth”) or used accounting information from multiple viewpoints to systematically analyze and value the existing possibilities (“systematic construction of models”).Pragmatic constructivism provides a solid starting point for identifying the gaps in the management practice that could be fulfilled by accounting employment. Moreover, with the central concepts of the approach, potentially more valuable accounting roles could also be analytically constructed and communicated to the practitioners. Besides addressing the gap between the potential and actual roles of NPD accounting, the paper represents the few attempts to elaborate the accounting roles in systematic decision-making through pragmatic constructivism. Thus, the paper reflects more explicitly also upon seminal work on the roles of accounting in managerial decisions.
Current status ofHelicobacter pyloriresistance to Clarithromycin and Levofloxacin in Malaysia—findings from a molecular based study
Authors: Puah Suat Moi , Goh Khean Lee , Ng Heng Kang , Chua Kek Heng 
Published: June 2021

BackgroundResistance to clarithromycin and levofloxacin inHelicobacter pyloriwhich resulted in treatment failures has become a major challenge for physicians worldwide. The resistance is mainly mediated by mutations in a specific domain of the 23S rRNA,gyrAandgyrBgenes for clarithromycin and levofloxacin respectively. Hence in this study, we aimed to investigate the current status ofH. pyloriresistance in our hospital to these two antibiotics based on the molecular approach.Materials and MethodsGastric biopsy samples were obtained from treatment-naïve patients. Bacterial genomic DNA was extracted using a commercial kit and continued with DNA amplification using polymerase chain reaction (PCR) with specific primers. The PCR amplicons were subjected to sequencing on 23S rRNA gene targeting nucleotide positions at 2,146, 2,147, 2,186 and amino acids atgyrApositions 87 and 91 andgyrBpositions 436, 438, 481, 484 to investigate the possible mutations or polymorphisms of genes that lead to clarithromycin and levofloxacin resistance respectively.ResultsSixty-one urease-positive gastric biopsy samples were studied. The findings revealed the primary resistance rates to clarithromycin was 14.8% and to levofloxacin was 3.3% in our current scenario based on detection of reported resistance-related mutations of A2147G and D91N in 23S rRNA andgyrAgenes, respectively. Interestingly, we found a high rate of silent mutations of thegyrAcodon 87Asn (32.8%, 20/61) and two polymorphisms of thegyrBD481E (16.4%, 10/61) and R484K (21.3%, 13/61). The role of these polymorphisms ingyrBremained to be elucidated whether the levels of levofloxacin resistance are related to the position/amino acid.ConclusionThe primary resistance rate ofH. pylorito clarithromycin has increased compared to the previous report in Malaysia. Therefore, molecular screening could aid and is important for the selection of antibiotics forH. pylorieradication therapies.
Geographic Distribution Shift of Invasive Plant Austroeupatorium inulifolium in the Future Climate Projection
Authors: Yudaputra Angga , Fijridiyanto Izu Andry , Astuti Inggit Puji , Zulkarnaen Rizmoon Nurul , Yuswandi Ade , Witono Joko R. , Yuzammi . 
Published: June 2021

Aims: This study aims to predict the future geographic distribution shift of invasive plant species Austroeupathorium inulifolium as the impact of global climate change.
Study Design: The rising temperature and precipitation change lead to the geographic distribution shift of organisms. A. inulifolium belongs to invasive plant species that often causes a substantial economic loss and ecological degradation in the invaded areas. Modelling of species distribution using the climate-based model could be used to understand the geographic distribution shift of invasive species in the future scenario under global climate change.
Place and Duration of Study: Center for Plant Conservation and Botanic Gardens – LIPI and 6 months.
Methodology: The total 2228 of occurrence records were derived from the Global Biodiversity Information Facility (GBIF) database. The seven climatic variables were selected from 19 variables using a pairwise correlation test (vifcor) with a threshold >0.7. The ensemble model was used by combining Random Forest (RF) and Support Vector Machine (SVM).
Results: Both two models are well-performed either using AUC or TSS evaluation methods. RF and SVM have AUC >0.95, and TSS >0.8. The predicted current distribution tends to have larger distribution areas compared to observed occurrence records. The predicted future distribution seems to be shifted in several parts of North America and Europe.
Conclusion: The geographic distribution of invasive plant species A. inulifolium will be shifted to the Northern part of globe in 2090. Mean temperature of driest quarter and precipitation of warmest quarter are the two most important variables that determine the distribution pattern of the A. inulifolium. The predictive distribution pattern of invasive plant A. inulifolium would be important to provide information about the impact of climate change to the geographic distribution shift of this species.
Extent of Home Based Care Program Support to Hospital Based Care for Children with Chronic and Terminal Illness in Meru County, Kenya
Authors: Kubai P. K. , Kei M. R. , Mutema A. M. 
Published: June 2021

Introduction: Chronic and Terminal illnesses continue to increase and aggravate the burden of disease and the diminish space in our hospitals and communities, Worldwide, 57 million persons died in 2008, an estimated 40 million were in need of HBCP, 6.6 - 10.8 million Children died, 98% Chronic and Terminal illnesses (CI/TI) are found in low and middle-income Countries. Chronic and Terminal illnesses in Children are on the rise in Sub Saharan Africa. Kenya lags in implementation of Home Based Care to mitigate effects of CI/TI. WHO, 2017 and Ministry of Health-Kenya 2013 shows that Children are affected by these Illnesses. These illnesses have made families’ to suffer psychosocial and economic hardships. Evaluation of determinants of Home Based Care Program (EHBCP) services by assessing if effective and quality delivery of HBCP Supports Hospital Based Care is key.
Aims: To determine the extent to which Home Based Care Program services Support to Hospital Based Care for Children aged 1-14 years diagnosed with selected Chronic and Terminal illnesses in Meru County Kenya.
Study Design: A descriptive Cross Sectional Survey.
Place and Duration of Study: Meru County, Kenya between June 2018 and Dec 2019.
Methodology: Methodology: Descriptive Cross Sectional Survey of 245 Caregivers of Children diagnosed with Chronic and Terminal illness were selected by proportionate to size sampling and simple random sampling from Meru County Health Facilities.
Results: Delivery of quality and effective Home Based Care Program was positively associated with age, return rate of over 100% was achieved with about 245 respondents being interviewed (132%),experience of Health Care Workers (HCWs) 4.8 [95% CI = 1.06 – 21.68, P = 0.041]. HCWs profession, gender and years of work were positively related to Hospital Based Care services 3.03 [95%CI = 1.64 – 5.59, P<0.001]. Use of minimum HBCP package was found to be useful in support of hospital care, as 50.4% reported that its support was of a good or great extent. The trend was observed in all aspects of the minimum HBCP package studied, with 52.4%, 54.4% and 46.4% having the opinion that use of the package by caregivers, in management and mitigation of complications supported hospital care by a good or great extent respectively.
Conclusion: Need for an urgent adoption of holistic approach on health care system strengthening by putting up a well-integrated Home Based Care Program with quality Minimum HBCP essential package to support the mainstream health care system. In addition adopt better management practices, planning strategies, resource allocation and monitoring for effective HBCP programmes as per the current guidelines to bridge the gaps identified in planning, management practices to fill the disjointed policy implementation and resource inadequacies in implementation of HBCP services to support Hospital Based care for ultimate delivery of quality care among the Chronically and Terminally ill Children.
Changes in the Levels of Biochemical Markers Following Coronavirus Infection in Patients with Liver Disease, Renal Disease and Diabetes Mellitus as Compared to Control Participants: A Cross Sectional Study
Authors: Ahmed Osama J. , Al-Wasiti Estabraq A. , Jamil Dina , Al-Aubaidy Hayder A. 
Published: June 2021

Background & Aim of the Study: Increased levels of many biomarkers, including liver enzymes, blood urea and serum creatinine as well as glycemic markers have been reported following coronavirus (COVID-19) infection, leading to the development of acute disease. This study aims to measure and follow-up the following biomarkers (fasting blood glucose, blood urea, serum creatinine, total serum bilirubin, as well as the liver enzymes AST, ALT, and ALP) in otherwise healthy participants and patients with liver disease, renal disease and diabetes following COVID-19 infection.
Materials and Methods: This is cross section study, included 144 participants who were infected with COVID-19 and admitted to the Sheikh Zayed Hospital, Baghdad, Iraq. Participants were divided into 4 study groups, Group 1: 46 participants with no pre-existing medical condition (Control), Group 2: 30 patients with existing liver disease. Group 3: 28 patients with existing renal disease and Group 4: 40 patients with diabetes mellitus. Participants were followed up for 14 days following COVID-19 infection to monitor the progression of the biochemical markers.
Results: There were significant changes in serum levels of all the markers of this study between the four study groups (p<0.001). Serum ALP levels were not significantly changed within any of the four study groups. However, both ALT and AST levels were significantly changed within all the four study groups (p<0.001). The levels of TSB changes significantly within the renal group (Group 3), (p=0.017). The levels of S. Creatinine showed significant changes in all the study groups except the renal group (Group 3). The levels change significantly within all the study groups except the control group (Group 1), while fasting blood glucose levels changes significantly in the control group only (Group 1), (p=0.004).
Conclusions: Following COVID-19 infection, there were significant changes in the levels of ALT, AST, S. Creatinine and B.Urea after 14 days of the disease progression. While in patients with existing renal disease, there were significant changes in the levels of TSB, AST, ALT and B. Urea following COVID-19 infection. In diabetic patients, there were significant increase in the level of fasting blood glucose after 14 days of COVID-19 infection. there were no significant changes in serum levels of ALP and FBG in patients with chronic illnesses (liver disease, renal disease, and diabetes) when compared to control group.
Characteristics of Masked Hypertension in Diabetes Mellitus Patientstype 2
Authors: Binh Vu Thanh , Thuy Nguyen Le , Hieu Le Minh 
Published: June 2021

Monitoring blood pressure with a continuous blood pressure monitor to carry around to detect masked hypertension (MH) in type 2 diabetes patients who are on outpatient treatment at Thai Binh Medical University Hospital, Thai Binh, Vietnam.
Objective: Analysis of MH characteristics in type 2 diabetic patients.
Research Methods: Cross-sectional descriptive study, sample size of 186 patients with type 2 diabetes with MH determined by blood pressure monitor 24 hours. Analysis of 24-hour blood pressure results in MH patients.
Results: 186 patients with hypertension / type 2 diabetes, including 77 men and 109 more, the average age is 62.2 ± 9.3 years old, there are 98.9% of hypertensive patients with grade I, only 1.1% of hypertensive patients degree II; MH at night accounted for the highest rate of 43.0%, of which the average systolic blood pressure was 123.8 ± 9.8 mmHg, and diastolic blood pressure was 75.2 ± 6.1 mmHg; On average, the highest increase is around 9 am and 19 pm, slightly down around 13pm and down at the deepest around 2-3am. There is a synchronous variation between systolic and diastolic blood pressure.
Conclusion: Blood pressure should be monitored continuously for 24 hours in all patients with type 2 diabetes to detect and promptly treat MH.
Chlorhexidine vs Routine Foot Washing to Prevent Diabetic Foot Ulcers
Authors: Lydecker Alison D. , Kim Justin J. , Robinson Gwen L. , Johnson J. Kristie , Brown Clayton H. , Petruccelli Christopher C. , Terrin Michael L. , Margolis David J. , Roghmann Mary-Claire 
Published: February 2025

ImportanceFoot ulcers are a common and feared complication for people with diabetes because 20% of foot ulcers become infected and lead to a lower extremity amputation.ObjectiveTo evaluate the effect of daily foot care using chlorhexidine wipes vs soap-and-water wipes for 1 year on the risk of developing new foot complications in veterans with diabetes.Design, Setting, and ParticipantsThis double-blind, placebo-controlled, phase 2b randomized clinical trial was conducted at the Baltimore Veterans Affairs (VA) Medical Center between January 2019 to January 2023. Veterans were eligible if they had a diabetes diagnosis, were at high risk for diabetic foot complications, were ambulatory, had both feet, and did not have a current foot infection. Participants were randomly assigned 1:1 to receive either soap-and-water wipes (control group) or 2% chlorhexidine wipes (chlorhexidine group). Intention-to-treat data analysis was conducted from October 5, 2023, to April 24, 2024.InterventionDaily use of a 2% chlorhexidine wipe or a soap-and-water wipe on the feet for 1 year. Wipes were nearly identical in color, size, shape, thickness, feel, and scent. Both chlorhexidine and control groups received the same lotion for application on the feet after wipe use and education on foot self-care.Main Outcomes and MeasuresThe primary outcome was time in days from randomization to new foot complication, including chronic foot ulcer, foot infection, or foot amputation.ResultsA total of 175 participants (170 males [97%]; mean [SD] age at enrollment, 68 [9] years; 1 Asian [1%], 117 Black or African American [67%], 53 White [30%] individuals) were randomly assigned to the chlorhexidine group (n = 88) or the control group (n = 87). Twelve participants (14%) in the chlorhexidine group and 14 participants (16%) in the control group developed a new foot complication within 1 year. Median (IQR) time from randomization to development of a new foot complication was 232 (115-315) days. The reduction in hazard of new foot complications in the chlorhexidine group compared with the control group was not significant (hazard ratio, 0.83; 95% CI, 0.39-1.80). The intervention was well tolerated, with 145 participants (83%) continuing it over the study period. Sixty adverse events occurred, but none was related to the study products or procedures.Conclusions and RelevanceThis randomized clinical trial found that daily use of chlorhexidine wipes for foot washing for 1 year did not lead to a significant reduction in the risk of new foot complications compared with daily use of soap-and-water wipes. The intervention was well tolerated, and the trial provides important lessons for future studies on diabetic foot ulcer prevention.Trial RegistrationClinicalTrials.gov Identifier: NCT03503370
A Spanish-Language Patient-Reported Outcome Measure for Trust in Pregnancy Care Clinician
Authors: Molina Rose L. , Bazan Maria , Hacker Michele R. , Kaimal Anjali J. , Alegría Margarita , Fernández Leonor , Guise Jeanne-Marie , Edelen Maria O. 
Published: February 2025

ImportanceDespite the importance of patient trust in health care, there are no patient-reported outcome measures (PROMs) for trust in their clinician that have been developed empirically in Spanish, which is the second most common language in the US.ObjectiveTo develop and validate a Spanish-language PROM for trust in pregnancy care clinician.Design, Setting, and ParticipantsThis cross-sectional study used a national online panel of patients who reported a Spanish language preference and had limited English proficiency and were currently pregnant or had given birth within the 12 months before the survey. Participants resided in the United States, and data were collected from January to May 2024.ExposuresParticipants had clinical interactions during pregnancy and/or postpartum care. Data collected included demographics, Confianza (Trust) Scale candidate items, and 4 measures for concurrent validity evidence: the Trust in Physician Scale (TPS), the Mothers on Respect Index, the Edinburgh Postpartum Depression Scale (EPDS), and the Patient-Reported Outcomes Measurement Information System Global 10.Main Outcomes and MeasuresThe main outcomes were psychometric properties of the Confianza scale and its association with validated scales (validity coefficients). Item response theory (IRT) analyses were conducted to evaluate the psychometric properties of the candidate items, select the best item subset for the Confianza scale, examine its correlation with other measures, and compare scores according to demographic characteristics.ResultsOf the included 204 participants (mean [SD] age, 26 [7] years; 62 participants from South America [30%]; 32 participants from Mexico [16%]), 117 participants were pregnant (57%), and 87 were within 1-year post partum (43%) at the time of survey completion. Four items were removed based on exploratory factor analysis. Using results from IRT analysis on the remaining 12 items, 5 items were selected to represent communication, caring, competency, accompaniment, and overall trust for the final measure. The 5-item Confianza scale had high measurement precision, with reliability above 0.90 across a wide range of the trust continuum. The Confianza scale (mean [SD] score, 21.5 [4.6] out of 25) was positively correlated with the TPS (r = 0.47; 95% CI, 0.36 to 0.57; P &amp;lt; .001) and negatively correlated with the EPDS (r = −0.41; 95% CI, −0.52 to −0.29; P &amp;lt;.001). Higher trust scores were obtained when there was language concordance with clinicians (mean [SD], 23.6 [2.3] vs 20.0 [5.3]; P &amp;lt; .001) and care continuity (mean [SD], 22.3 [3.8] vs 20.9 [5.3]; P = .001).Conclusions and RelevanceIn this cross-sectional study of pregnant and postpartum Spanish-speaking individuals, a Spanish-language PROM for trust in pregnancy care clinician had initial validity.
Tobacco and E-Product Use by US Adults With Disabilities
Authors: Parks Michael J. , Marshall Daniela , Kimmel Heather L. , Kingsbury John H. , Everard Colm D. , Aboaziza Eiman , Blanco Carlos , Compton Wilson M. 
Published: February 2025

ImportanceResearch on cumulative disabilities and tobacco use in the current tobacco landscape is lacking.ObjectiveTo examine prevalence of tobacco use across cumulative disabilities within and across years among US adults.Design, Setting, and ParticipantsRepresentative cross-sectional surveys of the US adult (aged ≥18 years) civilian, noninstitutionalized population from the Population Assessment of Tobacco and Health (PATH) Study were compared across 2013 to 2014 (wave 1), 2016 to 2018 (wave 4), and 2022 to 2023 (wave 7). Age-adjusted estimates and change scores were compared using design-based significance tests. Data were analyzed from November 2023 and April 2024.Main Outcomes and MeasuresPast 30-day use of tobacco (cigarette, electronic nicotine [e-product], traditional cigar, filtered cigar, cigarillo, pipe, hookah, and smokeless products); disability types (mobility, self-care, independent living, cognitive, hearing, and vision) summed to generate a 4-level cumulative disability measure (0, 1, 2, or ≥3).ResultsIn 2013 to 2014, among 32 314 participants at wave 1, 3110 participants were 65 years or older (18.2%), 15 993 (51.9%) were female, 5536 (15.2%) were Hispanic, 4496 (11.2%) were non-Hispanic Black, 19 295 (66.0%) were non-Hispanic White, and 2428 (7.5%) were another non-Hispanic race. A total of 32 314 adults were included in 2013 to 2014, 33 638 in 2016 to 2018, and 30 681 in 2022 to 2023. In 2013 to 2014, any tobacco use prevalence for those with no disabilities was 25.4% (95% CI, 24.7% to 26.1%), while prevalence was 40.2% (95% CI, 38.6% to 41.8%), 48.9% (95% CI, 45.4% to 52.5%), and 51.8% (95% CI, 48.6% to 55.0%) for those with 1, 2, and 3 or more disabilities, respectively. Any tobacco, cigarette, e-product, cigarillo, filtered cigar, and pipe use were consistently higher among those with multiple disabilities compared with those with 0 or 1 disability. Prevalence was highest among those with 3 or more disabilities for all products. Tobacco use declined over time, except e-product use increased. However, not all declines in prevalence between 2013 to 2014 and 2022 to 2023 were significant among those with 3 or more disabilities. The declines for those who used any tobacco (−4.6%; 95% CI, −8.7% to −0.6%) and cigarettes (−8.9%; 95% CI, −12.7% to −5.1%) were small, and increases in e-product use were large (4.6%; 95% CI, 1.0% to 8.3%) for those with 3 or more disabilities compared with other groups.Conclusions and RelevanceIn this survey study, disparities in tobacco use existed across cumulative disabilities. Despite declines in tobacco use over time, differences in use across cumulative disabilities persisted or worsened, especially among those with 3 or more disabilities. Targeted prevention, screening, and cessation efforts inclusive of multiple products are needed.