bluuebunny/crossref_metadata_2025_split huggingface dataset:
Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response
Authors: López‐Doménech Guillermo , Howden Jack H , Covill‐Cooke Christian , Morfill Corinne , Patel Jigna V , Bürli Roland , Crowther Damian , Birsa Nicol , Brandon Nicholas J , Kittler Josef T 
Published: June 2021

AbstractClearance of mitochondria following damage is critical for neuronal homeostasis. Here, we investigate the role of Miro proteins in mitochondrial turnover by the PINK1/Parkin mitochondrial quality control system in vitro and in vivo. We find that upon mitochondrial damage, Miro is promiscuously ubiquitinated on multiple lysine residues. Genetic deletion of Miro or block of Miro1 ubiquitination and subsequent degradation lead to delayed translocation of the E3 ubiquitin ligase Parkin onto damaged mitochondria and reduced mitochondrial clearance in both fibroblasts and cultured neurons. Disrupted mitophagy in vivo, upon post‐natal knockout of Miro1 in hippocampus and cortex, leads to a dramatic increase in mitofusin levels, the appearance of enlarged and hyperfused mitochondria and hyperactivation of the integrated stress response (ISR). Altogether, our results provide new insights into the central role of Miro1 in the regulation of mitochondrial homeostasis and further implicate Miro1 dysfunction in the pathogenesis of human neurodegenerative disease.
Single-Nucleus RNA Sequencing Identifies New Classes of Proximal Tubular Epithelial Cells in Kidney Fibrosis
Authors: Lu Yueh-An , Liao Chia-Te , Raybould Rachel , Talabani Bnar , Grigorieva Irina , Szomolay Barbara , Bowen Timothy , Andrews Robert , Taylor Philip R. , Fraser Donald 
Published: June 2021

Significance Statement
Proximal tubular cells (PTCs) are numerically the predominant constituent of the kidney and are central to regeneration versus organ fibrosis following injury. However, variations in their phenotype are not well characterized. Single-nuclear RNA sequencing revealed phenotypes of PTCs in normal mouse kidney and changes in kidneys undergoing regeneration and fibrosis following aristolochic acid exposure. Five abundant and four rare PTC phenotypes were found, with abundant clusters mapped to different tubular segments and rare phenotypes mapped to proliferative, dedifferentiated, and fibrosis-associated phenotypes. These data identify unrecognized heterogeneity in PTC phenotypes and reveal novel PTCs associated with kidney fibrosis.

Background
Proximal tubular cells (PTCs) are the most abundant cell type in the kidney. PTCs are central to normal kidney function and to regeneration versus organ fibrosis following injury. This study used single-nucleus RNA sequencing (snRNAseq) to describe the phenotype of PTCs in renal fibrosis.

Methods
Kidneys were harvested from naïve mice and from mice with renal fibrosis induced by chronic aristolochic acid administration. Nuclei were isolated using Nuclei EZ Lysis buffer. Libraries were prepared on the 10× platform, and snRNAseq was completed using the Illumina NextSeq 550 System. Genome mapping was carried out with high-performance computing.

Results
A total of 23,885 nuclei were analyzed. PTCs were found in five abundant clusters, mapping to S1, S1–S2, S2, S2-cortical S3, and medullary S3 segments. Additional cell clusters (“new PTC clusters”) were at low abundance in normal kidney and in increased number in kidneys undergoing regeneration/fibrosis following injury. These clusters exhibited clear molecular phenotypes, permitting labeling as proliferating, New-PT1, New-PT2, and (present only following injury) New-PT3. Each cluster exhibited a unique gene expression signature, including multiple genes previously associated with renal injury response and fibrosis progression. Comprehensive pathway analyses revealed metabolic reprogramming, enrichment of cellular communication and cell motility, and various immune activations in new PTC clusters. In ligand-receptor analysis, new PTC clusters promoted fibrotic signaling to fibroblasts and inflammatory activation to macrophages.

Conclusions
These data identify unrecognized PTC phenotype heterogeneity and reveal novel PTCs associated with kidney fibrosis.
Critique of radical religious paradigm: an epistemological analysis from principles of Islamic thought
Authors: Rohayana Ade Dedi , Sofi Muhammad Jauhari 
Published: June 2021

As one important factor enabling Islamophobia, radicalism has been a global issue endangering personal safety and public security. It is strongly associated with incorrect understanding of religious doctrines. This paper aims to present a critique of religious paradigm promoted by the radical groups from principles of Islamic thought (usul fiqh) perspective. Using epistemological analysis to uncover the nature of their religious understanding and its justification, this study argues that radical religious paradigm is characterized with monolithic, textual, and rigid interpretation of the sacred texts. According to the radical groups, the sources of Islamic laws or teachings are restricted to only the Quran and the hadith, leaving no space for alternative interpretations. They do not give a place for ra’yu (reason) in determining the laws or teachings. In the other hands, usul fiqh maintains that the sources of the Islamic laws or teachings are not restricted to only the two said sources; it also gives a place for ra’yu (reason). From usul fiqh perspective, the sources can also be found in the form of isyarah (signalling) and ruh (spirit) of the Quran and the hadith. In this sense, usul fiqh refuses the literal interpretation proposed by the radical groups since not all of the texts in the Quran and the hadith can be understood literally.
Worldview, religion, and urban growth: a geopolitical perspective on geography of power and conception of space during Islamization in Java, Indonesia
Authors: Setiadi Hafid 
Published: June 2021

Discussion of Islamization is not only associated with the spread of religious values but also related to the activity of trade and the opening of the new lands. In Java, all three of these themes have occurred simultaneously and then experienced rapid development since the 15th century. During the 15th and 17th centuries, many Islamic kingdoms rose and fell by turns with variuos ideology and their economic and political motives. As a result, Java experienced a complex of territorialization. By a spatial-historical approach, this article shows how territorialization affects the fashion of the emergence and collapse of the cities in Java. The spatial dynamics of urban growth reflected changes in political space production run by each ruling actor. The city played a significant role as a symbol and an identity of the political power of the dominant regime.
Implementasi Lean Hospital dalam Meningkatkan Pelayanan Rawat Jalan Poliklinik Penyakit Dalam
Authors: Kurniasih Dewi , Nuryakin Nuryakin , Pribadi Firman 
Published: June 2021

Permasalahan yang umum terjadi dalam pelayanan rawat jalan di rumah sakit adalah lamanya waktu tunggu, proses administrasi, ketersediaan informasi, dan yang lainnya. Salah satu pendekatan perbaikan kualitas yang digunakan dalam penelitian ini adalah lean hospital dengan tujuan untuk mencapai efektivitas dan efisiensi penggunaan waktu, tenaga kerja, ruang, dan sumber daya lainnya. Penelitian ini bertujuan untuk mengetahui gambaran value stream mapping (VSM), menganalisa hal yang menjadi waste, dan usulan perbaikan menggunakan pendekatan lean hospital pada pelayanan rawat jalan poliklnik penyakit dalam RS “X” di Indonesia. Penelitian dilakukan dengan pendekatan kualitatif melalui observasi langsung, wawancara mendalam dan telaah dokumen. Hasil penelitian menunjukkan nilai Non Value Added tertinggi adalah pada unit poliklinik yaitu sebesar (97,09%) dengan Value Added sebesar (2,91%) dan waiting time (107,22 menit) pada pelayanan pasien non-asuransi dengan pemeriksaan penunjang. Waste yang terjadi berupa waste of waiting, transportation, overproduction, overprocessing, inventory, motion, human potential dan defect. Dari hasil fishbone diagram diketahui bahwa akar penyebab masalah yang terjadi di unit poliklinik adalah dalam hal manajemen, peralatan, layout, petugas dan sistem informasi. Usulan perbaikan yang dapat diberikan berupa usulan jangka pendek, jangka menengah dan jangka panjang.
Kata kunci: rawat jalan, lean hospital, waste, value added, non value added, VSM
Long-term Experience of Subcutaneous Immunoglobulin Therapy in Primary Immunodeficient Patients with Low and Normal Body Weight
Authors: Gul Yahya , Kapakli Hasan , Guner Sukru Nail , Alan Havva Bozkurt , Sayar Esra Hazar , Keles Sevgi , Reisli Ismail 
Published: June 2021

Abstract
Purpose: The aim was to review the compliance, side effects and effectiveness of SCIG supplementation in patients with PID who had previously received IVIG therapy and subsequently switched to SCIG, as well as to compare these parameters in patients while considering body weight. Methods: Demographic data, clinical and laboratory findings, SCIG dose and side effects of 87 patients were retrospectively obtained from patient files.Results: Of the 87 patients aged between one and 22 years, 50 were male (57.5%) and 37 were female (42.5%). The serum IgG levels of the SCIG group were higher and more stable than those of the IVIG group. The number of hospitalizations and infections decreased significantly after initiation of SCIG. Thirteen patients (14.9%) had low body weight (LBW) for their age, seven of whom were male (53.8%). Serum IgG levels of the LBW cohort were significantly elevated and more stable during the SCIG period than the IVIG period. Mild, local side effects were detected in 153 administrations (3.3%) in 30 patients with normal body weight, while no local reactions were recorded in the patients with LBW. Conclusion: SCIG supplementation has become an effective treatment modality for pediatric patients and can be administered safely in LBW children with PID. The number of hospitalizations and family visits were reduced, allowing patients and their parents to continue their normal lives.
Assessing the Tropical South Atlantic atmosphere thermodynamics under distinct Sea Surface Temperature patterns
Authors: Silva Thiago L. V. , Veleda Doris , Costa Alexandre , Parise Claudia , Alves Rita , Tyaquica Pedro , Lopes Francis , Aroucha Leo 
Published: June 2021

Abstract
Northeast Brazil (NEB) is a susceptible region to the occurrence of extreme rainfall events. Sea surface temperature (SST) is used as an indicator for predicting intense weather events in this region. The westernmost Tropical South Atlantic region, also called Southern Atlantic Warm Pool (SAWP), is characterized by a source of heat and humidity which creates atmospheric instability for the NEB. In June 2010 the eastern coast of NEB (ENEB)was influenced by heavy rainfall, causing flash floods and landslides. On the other hand, 2012 marked the beginning of a period of droughts that affected the whole NEB area. The SAWP temperature in turn recorded anomalous values ​​of + 1ºC (-0.5ºC) in 2010 (2012), respectively, although in June 2012 intense rainfall was recorded in ENEB, even with intense negative SST anomalies. With the Coupled-Ocean-Atmosphere-Wave and Sediment Transport (COAWST) model, simulations were made to characterize 2010 and 2012 atmospheric conditions, modifying the SST input data in both situations. The goal of this work is to assess the meteorological systems that occurred in 2010 and 2012 using observational, reanalysis, and simulated data, as well as to identify changes in atmospheric instability patterns, which are under influences of different SST conditions. We performed four cases, including: a) SST measured in 2010 with 2010 atmospheric conditions; b) SST measured in 2012 with weather conditions of 2010; c) SST measured in 2012 with 2012 weather conditions; d) measured in2010 with atmospheric conditions from 2012. The results showed that SAWP temperature significantly influenced the instability of meteorological systems. The impacts were more significant in the lower layer of the atmosphere, especially in the variables that lead to low-level instabilities. Also, it was observed that warmer atmospheric conditions favor the ocean environment to remain warmer, maintaining the unstable conditions over SAWP.
The penetration of Human Defensin 5 (HD5) through bacterial outer membrane: Simulation studies
Authors: Awang Tadsanee , Pongprayoon Prapasiri 
Published: June 2021

Abstract
Human α-defensin 5 (HD5) is one of cationic antimicrobial peptides which plays a crucial role in an innate immune system in human body. HD5 shows the killing activity against a broad spectrum of pathogenic bacteria by making a pore in a bacterial membrane and penetrating into a cytosol. Nonetheless, its pore-forming mechanisms remain unclear. Thus, in this work, the constant-velocity steered molecular dynamics (SMD) simulation was used to simulate the permeation of a dimeric HD5 into a gram-negative LPS membrane model. Arginine-rich HD5 is found to strongly interact with a LPS surface. Upon arrival, arginines on HD5 interact with lipid A head groups and then drag these charged moieties down into a hydrophobic core resulting in the formation of water-filled pore. Although all arginines are found to interact with a membrane, R13 and R32 appear to play a dominant role in the HD5 adsorption on a gram-negative membrane. Furthermore, one chain of a dimeric HD5 is required for HD5 adhesion. The interactions of arginine-Lipid A head groups play a major role in adhering a cationic HD5 on a membrane surface and retarding a HD5 passage in the meantime.
Study on Population Changes of Important Sucking – Pests (Aphis Gossypii (Glov.) and Bemisia Tabaci (G.) in the New Varieties Second Plant (After Canola) in the Golestan Province of Iran.
Authors: Darvish Mojeni Taghi , Zangi Mohammadreza 
Published: June 2021

Abstract
Investigating the population dynamic of important cotton pests on new cotton varieties is important. Cotton cultivars have important pests such as thrips, aphids, whitefly and bollworm. Considering the premature cultivars with proper yield for second cultivation in cotton-growing Golestan province at the north of Iran, this study seems necessary. This genotypes was cultivated with 9 treatments in 4 replicates. A completely randomized block design was carried out in Hashem Abad research station in a spray-free plot with the dimensions of 30 × 80 cm in 2018-2019 years. According to the results of this study, analysis of variance of two years showed that the yield of N2G80 with 1538 g in the plot with 41.7% lint percentage had the highest yield, and M13 with 685 g in the plot and 35.8% lint percentage in the lowest yield they had.The infestation rate of the genotypes tested in the population of green aphid of cotton in K880-2 and Golestan® cultivars was 48.88 and 40.31 in aphid with the highest density, and the SKT-133 and TBL-60 genotype respectively with 27.15 and 29.11 aphids per leaf had the least infestation. The amount of infestation of the genotypes tested to the population of whitefly cotton on the N2G80 and TBL-60 genotype was 90.76 and 68.86 whitefly in the leaf with the highest infestation and N2G80 and TBL-60 genotype respectively with 40.05 and 75.51 white fly in leaf were the least infested. Correlation coefficient between traits was equal to 0.55. The number of bolls per plant was not correlated with other traits including boll weight, lint percentage, aphid and white fly.
Experimental and Modelling Studies of Water Sorption Properties of Cellulosic Derivative Fibers.
Authors: SIMON MATHILDE , FULCHIRON RENE , GOUANVE FABRICE 
Published: June 2021

Abstract
The objective of this study was to understand the chemical modification impact on interactions between water and cellulosic fiber. In that respect, cotton (C), flax (F), viscose (V) and cellulose acetate (CA) were analyzed by using a dynamic vapor sorption analysis. The sorption and desorption isotherms and kinetic curves were modelled using the Park model and the “Parallel Exponential Kinetics” (PEK) model-which allowed an accurate fitting on the whole range of water activity. The obtained sorption properties were correlated to the accessibility and the amount of sorption sites and also to the crystallinity level of the fibers. It was found that V exhibited the highest water sorption capacity due to a higher hydroxyl groups accessibility and a high amorphous fraction, followed up by F, C and CA. In contrast, higher kinetic sorption rate was obtained for CA due to a decrease of the hydroxyl groups within the fibers. Regardless the fiber, the determination of characteristic times showed that the kinetic rate was higher for sorption than desorption.
Restoring Force Model For A New Type of Bolted Prefabricated Beam-To-Column Joint
Authors: Haotian Jiang , Hailin Miao , Chenhua Jin , Qingning LI , Lei Yan 
Published: June 2021

Abstract
The wet prefabricated beam-to-column joint (PBCJ) has a densely reinforced panel zone and is difficult to construct, leading to poor connection reliability. To address this problem, we propose a dry PBCJ, where the concrete column is encased with steel plates at the connection and the beams and the column are connected by high-strength bolts. The method for constructing the joint is described herein. A total of six full-scale PBCJs were designed and subjected to quasi-static loading tests with different stirrup ratios, reinforcement strengths, and joint strengthening methods. Based on the test loading process, the joint failure mode is summarised, and a trilinear backbone curve model is proposed. According to the characteristics of the hysteresis curve and the backbone curve, the stiffness degradation law and hysteresis rule are analysed; then, the restoring force model for the new type of PBCJ is established, and the model results are compared with the test results. The data show that the new bolted PBCJ undergoes the cracking, yielding, ultimate, and failure stages; the trilinear backbone curve, which is composed of an elastic section, an elastoplastic section, and a plastic section, well describes the load-carrying characteristics of the joint. The backbone curve calculated by the established restoring force model is consistent with that obtained from the tests, indicating that the model can accurately describe the energy dissipation performance of the new PBCJ and thus provide a theoretical basis for the seismic performance analysis of this type of joint.
WITHDRAWN: Prognostic Nomograms based on Homogeneous and Heterogeneous Associated Factors for Predicting the Overall Survival of Colorectal Cancer Patients with Distant Metastases
Authors: Wang Hongmei , Shan Xuefeng , zhang min , Qian Kun , Zhou Weiying 
Published: June 2021

Abstract
Background: To identify the heterogeneous and homogeneous prognostic factors associated with distant metastases in colorectal cancer (CRC) patients and then construct nomograms to predict prognosis.Methods: CRC patients registered in the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2016 were included. Cox regression was used to analyse homogeneous and heterogeneous prognostic factors, and Kaplan-Meier analysis was used to estimate overall survival (OS). Predictive nomograms were constructed, and their performance was evaluated with C-indexes and calibration curves.Results: A total of 34933 patients with distant metastases were included. The median survival time of patients with liver metastases, lung metastases, bone metastases, and brain metastases were 12.00 months (95% CI: 11.71-12.29 months), 10.00 months (95% CI: 9.57-10.43 months), 5.00 months (95% CI: 4.47-5.53 months), and 3.00 months (95% CI: 2.31-3.70 months), respectively. Older age and no surgery were identified as homogeneous prognostic factors of the four types of metastases. Male sex, black race, unmarried status, uninsured status, primary CRC site, poor differentiation/grade, advanced N stage, T stage, high carcinoembryonic antigen (CEA) level and metastatic organ were heterogeneously associated with the prognosis of patients with distant metastases. The calibration curves and C-indexes exhibited good performance for predicting the OS of patients with distant metastases.Conclusion: CRC patients with distant metastases exhibited homogeneous and heterogeneous prognostic factors, all of which were associated with poor survival. The nomograms showed good accuracy and can be used as tools for clinicians to predict the prognosis of CRC patients with distant metastases.
Interrogating the Haemodynamic Effects of Haemodialysis Arteriovenous Fistula on Cardiac Structure and Function
Authors: Stoumpos Sokratis , Rankin Alastair , Barrientos Pauline Hall , Mangion Kenneth , McGregor Ellon , Thomson Peter C , Stevenson Karen , Welsh Paul , Kasthuri Ram , Kingsmore David B , Roditi Giles , Mark Patrick B 
Published: June 2021

Abstract
Arteriovenous fistula (AVF) is the preferred type of vascular access for maintenance haemodialysis but it may contribute to maladaptive cardiovascular remodelling. We studied the effect of AVF creation on cardiac structure and function in patients with chronic kidney disease (CKD). In this prospective cohort study patients with CKD listed for first AVF creation underwent cardiac magnetic resonance (CMR) imaging at baseline and at 6 weeks. All participants had ultrasound measurements of fistula blood flow at 6 weeks. The primary outcome was the change in left ventricular (LV) mass. Secondary outcomes included changes in LV volumes, LV ejection fraction, cardiac output, LV global longitudinal strain and N-terminal-pro B-type natriuretic peptide (NT-proBNP). A total of 55 participants were enrolled, of whom 40 (mean age 59 years) had AVF creation and completed both scans. On the second CMR scan, a mean increase of 7.4g (95%CI, 1.1–13.7, p=0.02) was observed in LV mass. Significant increases in LV end-diastolic volumes (p=0.04) and cardiac output (p=0.02) were also seen after AVF creation. No significant changes were observed in LV end-systolic volumes, LV ejection fraction, NT-proBNP and LV global longitudinal strain. In participants with fistula blood flows ≥600mL/min (n=22) the mean increase in LV mass was 15.5g (95%CI, 7.3–23.8) compared with a small decrease of 2.5g (95%CI, −10.6 to 5.6) in participants with blood flows <600mL/min (n=18). Creation of AVF for haemodialysis resulted in a significant increase of LV myocardial mass within weeks after surgery, which was proportional to the fistula flow.
The F- Topology on Space of Zero Dimensional rings
Authors: Mouadi Hassan , Karim Driss 
Published: June 2021

Abstract
Let R be a subring of a ring T, and let F be a non-principal ultrafilter on the natural numbers IN. We consider properties and applications of a countably compact, Hausdorff topology called the "F-topology" defined on space of all zero-dimensional subring of T that contains a fixed subring R. We show that the F-topology is strictly finer than the Zariski topology. We extend results regarding distinguished spectral topologies on the space of zero-dimensional subring.