bluuebunny/crossref_metadata_2025_split huggingface dataset:
Шляхи удосконалення тестування спеціального програмного забезпечення інформаційної системи управління оборонними ресурсами на етапі експлуатації
Authors: Руденська Г. 
Published: June 2021

З ростом ролі сучасних інформаційних систем (ІС) зростає складність спеціального програмного забезпечення (СПЗ) та підвищується ймовірність його уразливості. Експлуатація DRMIS, яка побудована на СПЗ з уразливістю може мати такі наслідки, як отримання доступу до конфіденційної інформації неавторизованими користувачами, порушення режиму функціонування та інші.
Метою статті є аналіз процедур тестування та виявлення уразливості СПЗ з метою підвищення рівня безпеки експлуатації DRMIS.
Тестування СПЗ DRMIS з метою виявлення уразливості включає три послідовні етапи: виявлення потенційної уразливості СПЗ і оцінювання можливості їх реалізації методом моделювання кібератак різного призначення; виявлення та реагування на інциденти, які пов’язані з проведеними кібератаками; ліквідація наслідків успішних кібератак. В процесі тестування СПЗ DRMIS встановлені наступні причини виникнення уразливості СПЗ DRMIS:
низький рівень менеджменту розробника;
критична структурна складність СПЗ DRMIS;
відсутність доступу до вихідного коду СПЗ;
недоліки проєктування, помилки програмування, ненадійні паролі, віруси та інші шкідливі програми;
розширення спектру навмисних загроз;
недостатня результативність формальних методів аналізу і тестування;
використання розробниками послуг краудсорсингу, проведення відкритих конкурсів по виявленню уразливості в СПЗ;
протиріччями між вимогами по колаборативній сертифікації і вимогами міжнародних стандартів;
використання програмної продукції, яка пройшла сертифікацію в Китаї і Росії;
політика імпортозаміщення і обмежень щодо використання імпортного СПЗ;
дискредитація міжнародної системи технічного та правового регулювання інформаційної та кібербезпеки.
Надійна експлуатація DRMIS передбачає, що ІС розроблена з урахуванням процедур, які дозволяють знизити рівень уразливості, а в разі їх виявлення оперативно доопрацювати СПЗ.
A atividade espasmolítica do óleo essencial obtido de Lippia microphylla Cham. (Verbenaceae) é mediada pela modulação da sinalização do cálcio em modelos animais e celulares
Authors: Oliveira Gislaine Alves de , Pereira Joedna Cavalcante , Martins Italo Rossi Roseno , Correia Ana Carolina de Carvalho , Travassos Rafael de Almeida , Silva Maria da Conceição Correia , Souza Iara Leão Luna de , Tavares Josean Fechine , Paredes-Gamero Edgar Julian , Silva Bagnólia Araújo da 
Published: June 2021

As espécies do gênero Lippia (Verbenaceae) são amplamente usadas na medicina tradicional no tratamento de desordens respiratórias e gastrointestinais. Neste estudo, avaliou-se o efeito relaxante do óleo essencial obtido de Lippia microphylla Cham. (LM‑EO) e seus componentes majoritários em íleo isolado de cobaias bem como elucidou‑se os mecanismos envolvidos. LM-EO inibiu as contrações fásicas e relaxou as tônicas induzidas por vários agentes contráteis em íleo de cobaia. Resultados semelhantes foram observados nos protocolos utilizando-se timol e carvacrol, os componentes majoritários de LM-EO. O bloqueio dos canais de cálcio dependentes de voltagem (CaV) foi sugerido uma vez que LM-EO deslocou para a direita e de maneira não paralela as contrações cumulativas induzidas por CaCl2 e confirmou-se quando LM-EO relaxou o íleo pré-contraído por S‑(‑)‑Bay K8644, um agonista seletivo dos CaV. Na camada muscular circular do íleo, LM-EO inibiu as contrações fásicas, sendo equipotente em relação aos efeitos no íleo íntegro. No miócitos isolados da camada longitudinal do íleo, LM-EO reduziu a intensidade da fluorescência induzida por histamina, semelhantemente ao verapamil (bloqueador CaV), indicando uma redução na concentração citosólica de cálcio ([Ca2+]c). Dessa forma, LM-EO apresenta uma atividade espasmolítica em íleo de cobaia pelo bloqueio dos CaV e consequente redução da [Ca2+]c. Esses resultados demostram-se como uma justificativa para o uso de L. microphylla como um produto terapêutico nas desordens intestinais.
Desvelando ideias socioambientais no Judiciário brasileiro
Authors: Costa Erica de Sousa , Vaz Ana Paula de Melo e Silva 
Published: June 2021

A pesquisa discorre acerca da Responsabilidade Socioambiental com base na Resolução nº 198/2014, do Conselho Nacional de Justiça, que disciplina sobre o Planejamento e a Gestão Estratégica no âmbito do Poder Judiciário, período 2015/2020. Objetiva analisar esse documento com foco na Responsabilidade Socioambiental. É uma pesquisa exploratória, balizada na abordagem qualitativa, que conjuga o procedimento bibliográfico e documental. No presente trabalho, são discutidas ideias socioambientais que retratam a Responsabilidade Socioambiental no cenário do Judiciário brasileiro, em uma retrospectiva com o recorte temporal do sexênio 2015/2020, com base nas instituições: Tribunal de Justiça do Acre (TJAC), Tribunal de Justiça do Maranhão (TJMA) e o Conselho Nacional de Justiça (CNJ). Conclui-se que, consoante a resolução esquadrinhada, a Responsabilidade Socioambiental é concebida como um dos atributos de valor do Judiciário para a sociedade. Infere-se ainda, na linha de estudos perquirida, que as ideias socioambientais demarcadas na investigação, criadas ou aperfeiçoada no sexênio 2015/2020, ensejam uma concepção que aponta para a promoção da sustentabilidade.
Terapia nutricionais nas doenças inflamatórias intestinais: Doença de Crohn e Retocolite Ulcerativa
Authors: Santos Amanda Luizy Camara , Dias Bianca Christina de Oliveira , Silva Klines Alves da , Ferreira José Carlos de Sales 
Published: June 2021

A terapia nutricional nas doenças inflamatórias intestinais vem se consolidando ao longo do tempo como um tratamento bastante eficaz e que tem como base uma dieta que vise combater essas patologias. Os meios nutricionais empregados obedecem aos critérios bem estruturados de acordo com os conhecimentos científicos adquiridos no extenso histórico de pesquisa desses aspectos da saúde dos indivíduos. O presente artigo ao tentar esclarecer esses benefícios, parte do pressuposto de que a incidência dessas enfermidades está altíssima e que para o seu devido tratamento, faz-se necessário uma gama maior de metodologias, dentre as quais destaca-se a terapia nutricional. Nas doenças inflamatórias crônicas as doenças inflamatórias intestinais estão classificadas como as de causas desconhecidas. Acredita-se que surjam da interação de quatro fatores fundamentais: ambiental, genético microbiano e imunológico. Essas doenças causam um grande impacto sobre a qualidade de vida do paciente, que é marcada por uma sobrecarga de terapias, hospitalizações e cirurgias.
Phage vB_PaeS-PAJD-1 Rescues Murine Mastitis Infected With Multidrug-Resistant Pseudomonas aeruginosa
Authors: Wang Zhaofei , Xue Yibing , Gao Ya , Guo Mengting , Liu Yuanping , Zou Xinwei , Cheng Yuqiang , Ma Jingjiao , Wang Hengan , Sun Jianhe , Yan Yaxian 
Published: June 2021

Pseudomonas aeruginosa is a Gram-negative pathogen that causes a variety of infections in humans and animals. Due to the inappropriate use of antibiotics, multi-drug resistant (MDR) P. aeruginosa strains have emerged and are prevailing. In recent years, cow mastitis caused by MDR P. aeruginosa has attracted attention. In this study, a microbial community analysis revealed that P. aeruginosa could be a cause of pathogen-induced cow mastitis. Five MDR P. aeruginosa strains were isolated from milk diagnosed as mastitis positive. To seek an alternative antibacterial agent against MDR, P. aeruginosa, a lytic phage, designated vB_PaeS_PAJD-1 (PAJD-1), was isolated from dairy farm sewage. PAJD-1 was morphologically classified as Siphoviridae and was estimated to be about 57.9 kb. Phage PAJD-1 showed broad host ranges and a strong lytic ability. A one-step growth curve analysis showed a relatively short latency period (20 min) and a relatively high burst size (223 PFU per infected cell). Phage PAJD-1 remained stable over wide temperature and pH ranges. Intramammary-administered PAJD-1 reduced bacterial concentrations and repaired mammary glands in mice with mastitis induced by MDR P. aeruginosa. Furthermore, the cell wall hydrolase (termed endolysin) from phage PAJD-1 exhibited a strong bacteriolytic and a wide antibacterial spectrum against MDR P. aeruginosa. These findings present phage PAJD-1 as a candidate for phagotherapy against MDR P. aeruginosa infection.
Left Ventricular Remodeling and Myocardial Work: Results From the Population-Based STAAB Cohort Study
Authors: Sahiti Floran , Morbach Caroline , Cejka Vladimir , Albert Judith , Eichner Felizitas A. , Gelbrich Götz , Heuschmann Peter U. , Störk Stefan 
Published: June 2021

Introduction: Left ventricular (LV) dilatation and LV hypertrophy are acknowledged precursors of myocardial dysfunction and ultimately of heart failure, but the implications of abnormal LV geometry on myocardial function are not well-understood. Non-invasive LV myocardial work (MyW) assessment based on echocardiography-derived pressure-strain loops offers the opportunity to study detailed myocardial function in larger cohorts. We aimed to assess the relationship of LV geometry with MyW indices in general population free from heart failure.Methods and Results: We report cross-sectional baseline data from the Characteristics and Course of Heart Failure Stages A-B and Determinants of Progression (STAAB) cohort study investigating a representative sample of the general population of Würzburg, Germany, aged 30–79 years. MyW analysis was performed in 1,926 individuals who were in sinus rhythm and free from valvular disease (49.3% female, 54 ± 12 years). In multivariable regression, higher LV volume was associated with higher global wasted work (GWW) (+0.5 mmHg% per mL/m2, p &lt; 0.001) and lower global work efficiency (GWE) (−0.02% per mL/m2, p &lt; 0.01), while higher LV mass was associated with higher GWW (+0.45 mmHg% per g/m2, p &lt; 0.001) and global constructive work (GCW) (+2.05 mmHg% per g/m2, p &lt; 0.01) and lower GWE (−0.015% per g/m2, p &lt; 0.001). This was dominated by the blood pressure level and also observed in participants with normal LV geometry and concomitant hypertension.Conclusion: Abnormal LV geometric profiles were associated with a higher amount of wasted work, which translated into reduced work efficiency. The pattern of a disproportionate increase in GWW with higher LV mass might be an early sign of hypertensive heart disease.
The Clinical Features of FLAIR-Hyperintense Lesions in Anti-MOG Antibody Associated Cerebral Cortical Encephalitis with Seizures: Case Reports and Literature Review
Authors: Wang Yun-feng , Liu Xue-wu , Lin Jian-ming , Liang Ji-ye , Zhao Xiu-he , Wang Sheng-jun 
Published: June 2021

BackgroundThe presence of fluid attenuated inversion recovery (FLAIR)-hyperintense lesions in anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated cerebral cortical encephalitis with seizures (FLAMCES) was recently reported. However, the clinical characteristics and outcome of this rare clinico-radiographic syndrome remain unclear.MethodsThe present study reported two new cases. In addition, cases in the literature were systematically reviewed to investigate the clinical symptoms, magnetic resonance imaging (MRI) abnormalities, treatments and prognosis for this rare clinico-radiographic syndrome.ResultsA total of 21 cases were identified during a literature review, with a mean patient age at onset of 26.8 years. The primary clinicopathological characteristics included seizures (100%), headache (71.4%), fever (52.3%) and other cortical symptoms associated with the encephalitis location (61.9%). The common seizure types were focal to bilateral tonic-clonic seizures (28.6%) and unknown-onset tonic-clonic seizures (38.1%). The cortical abnormalities on MRI FLAIR imaging were commonly located in the frontal (58.8%), parietal (70.6%) and temporal (64.7%) lobes. In addition, pleocytosis in the cerebrospinal fluid was reported in the majority of the patients (95.2%). All patients received a treatment regimen of corticosteroids and 9 patients received anti-epileptic drugs. Clinical improvement was achieved in all patients; however, one-third of the patients reported relapse following recovery from cortical encephalitis.ConclusionsFLAMCES is a rare phenotype of MOG-associated disease. Thus, the wider recognition of this rare syndrome may enable timely diagnosis and the development of suitable treatment regimens.
Mini Review: Virus Interference: History, Types and Occurrence in Crustaceans
Authors: Escobedo-Bonilla César Marcial 
Published: June 2021

Virus interference is a phenomenon in which two viruses interact within a host, affecting the outcome of infection of at least one of such viruses. The effect of this event was first observed in the XVIII century and it was first recorded even before virology was recognized as a distinct science from microbiology. Studies on virus interference were mostly done in the decades between 1930 and 1960 in viruses infecting bacteria and different vertebrates. The systems included in vivo experiments and later, more refined assays were done using tissue and cell cultures. Many viruses involved in interference are pathogenic to humans or to economically important animals. Thus the phenomenon may be relevant to medicine and to animal production due to the possibility to use it as alternative to chemical therapies against virus infections to reduce the severity of disease/mortality caused by a superinfecting virus. Virus interference is defined as the host resistance to a superinfection caused by a pathogenic virus causing obvious signs of disease and/or mortality due to the action of an interfering virus abrogating the replication of the former virus. Different degrees of inhibition of the superinfecting virus can occur. Due to the emergence of novel pathogenic viruses in recent years, virus interference has recently been revisited using different pathogens and hosts, including commercially important farmed aquatic species. Here, some highly pathogenic viruses affecting farmed crustaceans can be affected by interference with other viruses. This review presents data on the history of virus interference in hosts including bacteria and animals, with emphasis on the known cases of virus interference in crustacean hosts.Life Science Identifiers (LSIDs)Escherichia coli [(Migula 1895) Castellani &amp; Chalmers 1919]Aedes albopictus (Skuse 1894)Liocarcinus depurator (Linnaeus 1758): urn:lsid:marinespecies.org:taxname:107387Penaeus duorarum (Burkenroad 1939): urn:lsid:marinespecies.org:taxname:158334Carcinus maenas (Linnaeus 1758): urn:lsid:marinespecies.org:taxname:107381Macrobrachium rosenbergii (De Man 1879): urn:lsid:marinespecies.org:taxname:220137Penaeus vannamei (Boone 1931): urn:lsid:zoobank.org:pub:C30A0A50-E309-4E24-851D-01CF94D97F23Penaeus monodon (Fabricius 1798): urn:lsid:zoobank.org:act:3DD50D8B-01C2-48A7-B80D-9D9DD2E6F7ADPenaeus stylirostris (Stimpson 1874): urn:lsid:marinespecies.org:taxname:584982
Elevated HDL Levels Linked to Poorer Cognitive Ability in Females With Parkinson’s Disease
Authors: Bakeberg Megan C. , Gorecki Anastazja M. , Kenna Jade E. , Jefferson Alexa , Byrnes Michelle , Ghosh Soumya , Horne Malcolm K. , McGregor Sarah , Stell Rick , Walters Sue , Mastaglia Frank L. , Anderton Ryan S. 
Published: June 2021

IntroductionCholesterol levels have been associated with age-related cognitive decline, however, such an association has not been comprehensively explored in people with Parkinson’s disease (PD). To address this uncertainty, the current cross-sectional study examined the cholesterol profile and cognitive performance in a cohort of PD patients.MethodsCognitive function was evaluated using two validated assessments (ACE-R and SCOPA-COG) in 182 people with PD from the Australian Parkinson’s Disease Registry. Total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and Triglyceride (TRG) levels were examined within this cohort. The influence of individual lipid subfractions on domain-specific cognitive performance was investigated using covariate-adjusted generalised linear models.ResultsFemales with PD exhibited significantly higher lipid subfraction levels (TC, HDL, and LDL) when compared to male counterparts. While accounting for covariates, HDL levels were strongly associated with poorer performance across multiple cognitive domains in females but not males. Conversely, TC and LDL levels were not associated with cognitive status in people with PD.ConclusionHigher serum HDL associates with poorer cognitive function in females with PD and presents a sex-specific biomarker for cognitive impairment in PD.
Platelet Derived Growth Factor-AA Correlates With Muscle Function Tests and Quantitative Muscle Magnetic Resonance in Dystrophinopathies
Authors: Alonso-Jiménez Alicia , Fernández-Simón Esther , Natera-de Benito Daniel , Ortez Carlos , García Carme , Montiel Elena , Belmonte Izaskun , Pedrosa Irene , Segovia Sonia , Piñol-Jurado Patricia , Carrasco-Rozas Ana , Suárez-Calvet Xavier , Jimenez-Mallebrera Cecilia , Nascimento Andrés , Llauger Jaume , Nuñez-Peralta Claudia , Montesinos Paula , Alonso-Pérez Jorge , Gallardo Eduard , Illa Isabel , Díaz-Manera Jordi 
Published: June 2021

Introduction: Duchenne (DMD) and Becker (BMD) muscular dystrophy are X-linked muscular disorders produced by mutations in the DMD gene which encodes the protein dystrophin. Both diseases are characterized by progressive involvement of skeletal, cardiac, and respiratory muscles. As new treatment strategies become available, reliable biomarkers and outcome measures that can monitor disease progression are needed for clinical trials.Methods: We collected clinical and functional data and blood samples from 19 DMD patients, 13 BMD patients, and 66 healthy controls (8 pediatric and 58 adult controls), and blood samples from 15 patients with dysferlinopathy (DYSF) and studied the serum concentration of 4 growth factors involved in the process of muscle fibrosis. We correlated the serum concentration of these growth factors with several muscle function tests, spirometry results and fat fraction identified by quantitative Dixon muscle MRI.Results: We found significant differences in the serum concentration of Platelet Derived Growth Factor-AA (PDGF-AA) between DMD patients and pediatric controls, in Connective Tissue Growth Factor (CTGF) between BMD patients and adult controls, and in and Transforming Growth Factor- β1 (TGF-β1) between BMD and DYSF patients. PDGF-AA showed a good correlation with several muscle function tests for both DMD and BMD patients and with thigh fat fraction in BMD patients. Moreover, PDGF-AA levels were increased in muscle biopsies of patients with DMD and BMD as was demonstrated by immunohistochemistry and Real-Time PCR studies.Conclusion: Our study suggests that PDGF-AA should be further investigated in a larger cohort of DMD and BMD patients because it might be a good biomarker candidate to monitor the progression of these diseases.
Epilepsy Associated With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes
Authors: Li Jiaai , Zhang Wuqiong , Cui Zhitao , Li Zhaoran , Jiang Ting , Meng Hongmei 
Published: June 2021

Objectives: The present study explored the clinical characteristics and prognostic factors of epilepsy in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS).Methods: Thirty-four MELAS patients were included in the present study. They were diagnosed by clinical characteristics, genetic testing, muscle biopsy, and retrospective analysis of other clinical data. The patients were divided into three groups according to the effects of treatment after at least 2 years of follow-up.Results: Epilepsy was more common in male MELAS patients than in females (20/14). The age of onset ranged from 0.5 to 57 years, with an average of 22.6 years. Patients with epilepsy and MELAS had various forms of seizures. Focal seizures were the most common type affecting 58.82% of patients, and some patients had multiple types of seizures. The abnormal EEG waves were mainly concentrated in the occipital (69.57%), frontal (65.22%) and temporal lobes (47.83%). Overall, the prognosis of patients with epilepsy and MELAS was poor. Poor prognosis was associated with brain atrophy (P = 0.026), status epilepticus (P &lt; 0.001), and use of anti-seizure medications with high mitochondrial toxicity (P = 0.015).Interpretation: Avoiding the application of anti-seizure medications with high mitochondrial toxicity, controlling seizures more actively and effectively, and delaying the occurrence and progression of brain atrophy as much as possible are particularly important to improve the prognosis of patients with MELAS and epilepsy.
Evaluation of Endovascular Treatment for Acute Basilar Occlusion in a State-Wide Prospective Stroke Registry
Authors: Gruber Katharina , Misselwitz Björn , Steinmetz Helmuth , Pfeilschifter Waltraud , Bohmann Ferdinand O. 
Published: June 2021

Context: Despite overwhelming evidence for endovascular therapy in anterior circulation ischemic stroke due to large-vessel occlusion, data regarding the treatment of acute basilar artery occlusion (BAO) are still equivocal. The BASICS trial failed to show an advantage of endovascular therapy (EVT) over best medical treatment (BMT). In contrast, data from the recently published BASILAR registry showed a better outcome in patients receiving EVT.Objective: The aim of the study was to investigate the safety and efficacy of EVT plus BMT vs. BMT alone in acute BAO.Methods: We analyzed the clinical course and short-term outcomes of patients with radiologically confirmed BAO dichotomized by BMT plus EVT or BMT only as documented in a state-wide prospective registry of consecutive patients hospitalized due to acute stroke. The primary endpoint was a favorable functional outcome (mRS 0–3) at hospital discharge assessed as common odds ratio using binary logistic regression. Secondary subgroup analyses and propensity score matching were added. Safety outcomes included mortality, the rate of intracerebral hemorrhages, and complications during hospitalization.Results: We included 403 patients with acute BAO (2017–2019). A total of 270 patients (67%) were treated with BMT plus EVT and 133 patients (33%) were treated with BMT only. A favorable outcome (mRS 0–3) was observed in 33.8% of the BMT and 26.7% of the BMT plus EVT group [OR.770, CI (0.50–1.2)]. Subgroup analyses for patients with a NIHSS score &gt; 10 at admission to the hospital revealed a benefit from EVT [OR 3.05, CI (1.03–9.01)].Conclusions: In this prospective, quasi population-based registry of patients hospitalized with acute BAO, BMT plus EVT was not superior to BMT alone. Nevertheless, our results suggest that severely affected BAO patients are more likely to benefit from EVT.