bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological Burden of the COVID-19 Pandemic – the Voice of the Young Doctors’ Generation: an International Survey.
Authors: Czerwińska-Jelonkiewicz Katarzyna , Beneria Anna , Baneras Jordi , Kwasiborski Przemysław , Velagapudi Poonam , Ijioma Nkechinyere , Trêpa Maria , Fekadu Chala , Vandenbriele Christophe , Stratinaki Maria , Tun Han Naung , Garaygordobil Diego Araiza , Verdoia Monica , Moscatelli Sara , Shchendrygina Anastasia , Wood Alice , Johnson Victoria , Reinstadler Sebastian , Aleksic Milica , Pazdernik Michał , Rosenberg Alex 
Published: September 2021

Abstract
Background: Young doctors have made up a substantial part of healthcare forces during the Coronavirus Disease 2019 (COVID-19) pandemic. The aim of this study was to determine the rate and level of psychological distress among young doctors during the COVID-19 outbreak. Methods: This cross-sectional cohort study, dedicated to doctors, at or below the age of 40, was conducted in 62 countries as an online survey between September – November 2020. Survey questions covered the following areas: 1. demographics 2. work environment 3.the ‘Hospital Anxiety and Depression Scale (HADS)’ and the ‘Perceived Stress Scale 10 (PSS-10)’. The primary outcome was the rate and level of anxiety/depression and stress among surveyed population defined according to adopted cut off values (HADS>13, PSS-10>14). Secondary outcomes included risk factors for increased HADS and PSS-10 scores.Results: Among 1186 respondents, median aged 32 [29–36], 675 (44.5%) females, 96% reported a high level of anxiety/depression and 97% reported a high level of stress. Factors associated with significantly higher scores for anxiety/depression were increased work hours [OR 1.61 95%CI (1.12–2.34);p=0.01] and loss of pay [OR 5.53, 95% CI (1.57–19.47);p=0.008], while reduced work hours [OR 0.68 95% CI (0.48 - 0.98);p=0.03], increased salaries [OR 0.54 95% CI (0.35–0.85);p=0.003) and good training [OR 0.99 95%CI (0.99– 1.00);p=0.002] were associated with lower scores. Higher scores for stress were associated with higher professional experience [OR 1.08 95% CI (1.02–1.14);p=0.008], reduced salaries [OR 1.74 95% CI (1.01–2.92);p=0.04] and living with a partner [OR 1.53 95% CI (1.08–2.17);p=0.01]. Conclusions: A high rate of young doctors working clinically during the COVID-19 pandemic reported a persistently high level of psychological distress more than six months after the initial outbreak. Improvements in work organization, including reduced work hours and financial security are essential to prevent further psychological suffering among young doctors worldwide.
Assessing the suitability of chemical ameliorants for reducing bio-availability of heavy metals in bulk fly ash contaminated soil
Authors: Mandal Joy Kumar , Mukherjee Siddhartha , Saha Niharendu , Halder Nibedan , Chakraborty Sanjoy 
Published: September 2021

Abstract
In-situ rehabilitation of fly ash at dumping sites has been rarely addressed for crop production due to growth-related constraints, largely of heavy metal (HM) contamination in soils and crops. Current communication deals with a novel approach to identify a suitable management option for rejuvenating the contaminated soils. In this background, a 60-days incubation experiment was conducted with different fly ash-soil mixtures (50 + 50%, A1; 75 + 25%, A2; 100 + 0%, A3) along with four ameliorants, namely, lime (T1), sodium sulphide (T2), di-ammonium phosphate (T3), and humic acid (T4) at 30 ± 2 0 C to assess the ability of different fly ash-soil-ameliorant mixtures in reducing bio-availability of HMs. DTPA-extractable bio-available HM contents for lead (Pb), cadmium (Cd), nickel (Ni), and chromium (Cr) and their respective ratios to total HM contents under the influence of different treatments were estimated at different stages of incubation. Further, the ecotoxicological impact of different treatments on soil microbial properties was studied. A1T1 significantly recorded the lowest bio-availability of HMs (~ 49–233% lower) followed by A2T1 (~ 35–133%) among the treatments. The principle component analysis also confirmed the superiority of A1T1 and A2T1 in this regard. Further, A1T1 achieved low contamination factor and ecological risk with substantial microbial biomass carbon load and dehydrogenase activity. Thus, liming to fly ash-soil mixture at 50:50 may be considered as the best management option for ameliorating metal toxicity. This technology may guide thermal power plants to provide the necessary package of practices for the stakeholders to revive their contaminated lands for better environmental sustainability.
Oral Semaglutide in the Management of Type 2 DM: Clinical Status and
Comparative Analysis
Authors: Bandyopadhyay Ilora , Dave Sunny , Rai Amita , Nampoothiri Madhavan , Chamallamudi Mallikarjuna Rao , Kumar Nitesh 
Published: September 2021

Background:
In the incretin system, Glucagon-like peptide-1 (GLP-1) is a hormone that
inhibits the release of glucagon and regulates glucose-dependent insulin secretion. In type 2 diabetes,
correcting the impaired incretin system using GLP-1 agonist is a well-defined therapeutic
strategy.

Objectives:
This review article aims to discuss the mechanism of action, key regulatory events, clinical
trials for glycaemic control, and comparative analysis of semaglutide with the second-line antidiabetic
drugs.

Description:
Semaglutide is a glucagon-like peptide 1 (GLP-1) receptor agonist with enhanced glycaemic
control in diabetes patients. In 2019, USFDA approved the first oral GLP-1 receptor agonist,
semaglutide, to be administered as a once-daily tablet. Further, recent studies highlight the ability
of semaglutide to improve Glycemic control in obese patients with a reduction in body weight.
Still, in clinical practice, in the type 2 DM treatment paradigm, the impact of oral semaglutide remains
unidentified. This review article discusses the mechanism of action, pharmacodynamics, key
regulatory events, and clinical trials regarding glycaemic control.

Conclusion:
The review highlights the comparative analysis of semaglutide with the existing second-
line drugs for the management of type 2 diabetes mellitus by stressing its benefits and adverse
events.
Molecular Docking Studies, Chemical Composition, Antioxidant, Cytotoxicity,
Antibacterial and Antifungal Activities of Globularia alypum
Extract
Authors: Hajji Najla , Bayar Sihem , Zouari Nacim , Altayb Hisham , Sebai Hichem , Chaieb Kamel 
Published: September 2021

Background:
Globularia alypum L. is a Mediterranean plant of the Globulariaceae family
which has been used in folk medicine to cure several diseases. Different studies have been done
in vitro and in vivo using diverse G. alypum extracts to understand this traditional use.

Methods:
In this study, Tunisian G. alypum leaf methanol extract (GAME) was chemically identified
using LC-ESI-MS, then examined in vitro for its antioxidant, antibacterial, and antifungal activities.
Besides, a molecular docking study was also conducted.

Results:
Nineteen phenolic compounds were detected, with trans-cinnamic acid (45.14%) and luteolin
7-O-glucoside (19.82%) being the dominant ones. The GAME demonstrated important antioxidant
activities, especially against 2, 2-diphenyl-l-1-picrylhydrazil (DPPH) radical (IC50 = 16.1±1.1
μg.ml-1) and exhibited an anti-proliferative effect against Vero cells with (IC50 2091 ± 177
μg.ml-1). Data also reveals that the GAME inhibited the growth of oral bacteria, in particular Streptococcus
oralis (MICs value ranged from 2560 to 20480 μg.ml-1). In addition, GAME has a significant
antifungal action, especially against Candida albicans ATCC 90028 (MIC=2560 μg.ml-1).
Docking study identified one of the major molecules (luteolin 7-O-glucoside) present in the
GAME extract, displaying a good interaction with tyrosinase (docking score -9.6 kcal.mol-1) and
other antibacterial (tyrosyl-tRNA synthetase, gyrase, deformylase) and antifungal (n-myristoyltransferase,
chitinase) target proteins.

Conclusion:
This study illustrates that GAME has potent sources of antioxidants and antimicrobials
useful in combating oral bacteria. Hence GAME can be of reasonable use in food technology,
processing, as well as the medical field.
Association of Body Composition with Functional Capacity and Cognitive
Function in Older Adults Living in Nursing Homes
Authors: Stavrinou Pinelopi S. , Aphamis George , Andreou Eleni , Pantzaris Marios , Giannaki Christoforos D. 
Published: September 2021

Objective:
Older adults living in nursing homes have an increased risk of adverse outcomes.
However, the role of body composition in vital health and quality of life parameters such as
functional capacity and cognitive function is less studied in this group of older adults compared to
community-dwelling counterparts.

Objective:
The aim of the present study was to examine the association of body composition with
functional capacity and cognitive function in nursing home residents.

Methods:
Fifty-three older adults (82.8 ± 7.3 years) were enrolled in this study and they underwent
body composition evaluation, functional capacity and cognitive function measurements.The results showed a high prevalence of obesity accompanied by functional capacity limitations
and cognitive impairment in older adults living in nursing homes. Partial correlations, controlling
for age, showed that body fat percentage was positively correlated with sit-to-stand-5 (r =
0.310, p = 0.025) and timed-up-and-go (r = 0.331, p = 0.017), and negatively correlated with handgrip
strength test results (r = -0.431, p<0.001), whereas greater lean body mass was associated with
better sit-to-stand-5 (r = -0.410, p = 0.003), handgrip strength (r=0.624, p<0.001) and cognitive
function performance (r = 0.302, p = 0.037).

Results:
The results showed a high prevalence of obesity accompanied by functional capacity limitations
and cognitive impairment in older adults living in nursing homes. Partial correlations, controlling
for age, showed that body fat percentage was positively correlated with sit-to-stand-5 (r =
0.310, p = 0.025) and timed-up-and-go (r = 0.331, p = 0.017), and negatively correlated with handgrip
strength test results (r = -0.431, p<0.001), whereas greater lean body mass was associated with
better sit-to-stand-5 (r = -0.410, p = 0.003), handgrip strength (r=0.624, p<0.001) and cognitive
function performance (r = 0.302, p = 0.037).

Conclusions:
These important associations reinforce the need to develop effective healthy lifestyle
interventions targeting both lean mass and body fat to combat functional and cognitive decline in
nursing home residents.
Assessment of Nursing Students’ Attitudes Towards Recording and Protecting
Patients’ Personal Health Data: A Descriptive Study
Authors: Atalıkoğlu Başkan Sebahat , Karakurt Papatya , Kasımoğlu Necla 
Published: September 2021

Introduction. Since health information is considered as sensitive personal data
and requires more careful protection, healthcare professionals need to be careful about
this issue. The objective of this research was to determine nursing students’
attitudes towards recording and protecting patients’ personal health data.
Materials and Methods. The population of this descriptive research consisted of 450
students who studied at the Department of Nursing, Faculty of Health Sciences, Erzincan
Binali Yildirim University. Sample selection was not used, and the research was
completed with 374 students who were continuing education and who were accepted to
participate in the research. Descriptive Information template and Attitude Scale for
Recording and Protecting Personal Health Data for nursing students were used as
data-collection instruments. The numbers, percentage, mean, standard deviation,
non-parametric tests (the Mann-Whitney U test and the Kruskal-Wallis test) were used in
data analysis. Results. Among our research participants, 68.4% of the students were
females; 28.1% of the students were freshmen; 69% of the students were graduates of
Anatolian high schools. Approximately 72.5% and 52.9% of the participants stated that
they were aware of the concept of “personal data” and “personal health data” ,
respectively. The mean score of nursing students on the Attitude Scale for Recording and
Protecting Personal Health Data was 3.97±0.71. The means scores obtained from subscales
were as follows: 3.91±0.72 for Personal Health Data Information, 4.15±0.80 for Legal
Information, 4.05±0.94 for Legal Data Sharing, 3.90±0.80 for Personal Health Data
Sharing, and 3.77±0.33 for Recording of Personal Health Data, respectively. A
statistically significant difference was found between the total scale and subscale
scores of the students regarding their academic level. Conclusions. Students were
found to have a positive attitude towards recording and protecting personal data.
Increasing the responsibilities and raising awareness of the students for the protection
of personal health data during their study is suggested to be important.
Dual-Energy Multidetector Computed Tomography: A Highly Accurate Non-Invasive Tool
for in Vivo Determination of Chemical Composition of Renal Calculi
Authors: Bhawani Shafqat Shabir , Jehangir Majid , Masood Mohammad , Dar Sajjad Ahmad , Syed Sajad Nazir 
Published: September 2021

Introduction. Computed tomography is more accurate than excretory urography in
evaluation of renal stones due to its high sensitivity and temporal resolution; it
permits sub-millimetric evaluation of the size and site of calculi but cannot evaluate
their chemical composition. Dual-energy computed tomography allows evaluating the
chemical composition of urinary calculi using simultaneous image acquisition at two
different energy levels. The objective of the research was to determine renal stone
composition using dual-energy multidetector computed tomography, and its correlation
with post-extraction chemical analysis of stones. Materials and Methods. This
prospective study was conducted in the Department of Radiodiagnosis and Imaging from
September 2017 to March 2019. A total of 50 patients with urolithiasis at the age of
18-70 years were included in the study. Dual-energy computed tomography ratios of
various stones were noted, and preoperative composition of calculi was given based on
their colour and dual-energy computed tomography ratio. These results were compared with
the post-extraction chemical analysis of stones (using Fourier infrared transform
spectroscopy as the standard comparative method.) Results. The most common type of
calculi in our study population was calcium oxalate stones (78%) followed by uric acid
stones (12%), cystine stones (6%) and hydroxyapatite stones (4%). The dual-energy ratio
of calcium oxalate, uric acid, cystine and hydroxyapatite stones ranged from 1.38-1.59,
0.94-1.08, and 1.20-1.28 and 1.52-1.57, respectively, with the mean dual-energy ratio of
1.43, 1.01, 1.25 and 1.55, respectively. Dual-energy computed tomography was found to be
100% sensitive and specific for differentiating uric acid stones from non‑uric acid
stones. The sensitivity and specificity in differentiating calcium oxalate calculus from
non‑calcium oxalate calculus was 97.5% and 90.9%, respectively, with 96% accuracy and
kappa value of 0.883 suggesting strong agreement. Conclusions. Dual-energy computed
tomography is highly sensitive and accurate in distinguishing between various types of
renal calculi. It has vital role in management as uric acid calculi are amenable to drug
treatment, while most of non-uric acid calculi require surgical intervention.
Features of Changes in the Structural and Functional State of the Myocardium in
Patients with Acute Myocardial Infarction Depending on Body Mass Index Considering FABP4
and CTRP3 Levels
Authors: Koteliukh Mariia 
Published: September 2021

Introduction. Adipokines such as fatty acid-binding protein 4 (FABP4) and C1q
tumor necrosis factor-related protein 3 (CTRP3) can affect the structural and functional
state of the myocardium in patients with acute myocardial infarction and obesity.
The objective of the research was to determine the relationship between FABP4, CTRP3 and
echocardiographic parameters of the left ventricular myocardium in patients with acute
myocardial infarction depending on body mass index. Materials and Methods. The
observational cross-sectional study examined 189 patients with acute myocardial
infarction depending on body mass index, who were divided into the following groups:
Group 1 included 60 patients with acute myocardial infarction and normal body mass
index; Group 2 comprised 68 patients with acute myocardial infarction and excess body
weight; Group 3 included 61 patients with acute myocardial infarction and obesity.
Results. In Group 1, the statistical significance correlations were found: between FABP4
and end-diastolic dimension (EDD; r = -0.458), end-systolic dimension (ESD; r = -0.460),
end-diastolic volume (EDV; r = -0.452), left ventricular myocardial mass (LVMM; r =
-0.411), LVMM/body surface area index (LVMMI2; r = -0.419); between CTRP3 and EDV (r =
0.425), EDD (r = 0.469), left ventricular relative posterior wall thickness (LVRPWT; r =
-0.469). In Group 2, there were found the statistical significance relationships
between: FABP4 and EDD (r = 0.461), ESD (r = 0.467), EDV (r = 0.449), end-systolic
volume (ESV; r = 0.485), LVMM (r = 0.487), LVMMI1 (r = 0.406); between CTRP3 and EDD (r
= -0.440), EDV (r = -0.413), LVMM (r = -0.430), LVMM/height2.7 index (LVMMI1; r =
-0.483). In Group 3, the statistical significance correlations were found between: FABP4
and EDV (r = 0.481), ESD (r = 0.411), ESV (r = 0.490), LVMMI1 (r = 0.403); between CTRP3
and EDV (r = -0.326), ESD (r = -0.367), ESV (r = -0.453), LVMMI1 (r = -0.415).
Conclusions. In patients with acute myocardial infarction and overweight/obesity,
echocardiographic parameters had a significant low positive correlation with FABP4 and a
low negative correlation with CTRP3. On the contrary, in patients with acute myocardial
infarction and normal body mass index, echocardiographic parameters had a significant
low negative correlation with FABP4 and a low positive correlation with CTRP3.
Ảnh hưởng của điều kiện trích ly và cô quay chân không đến đặc tính của cao chiết từ vỏ bưởi da xanh (Citrus maxima (Burn.) Merr.)
Authors: Tô Nguyễn Phước Mai , Mười Nguyễn Văn 
Published: September 2021

Nghiên cứu được thực hiện với mục đích đánh giá hiệu quả thu nhận thành phần polyphenol hòa tan từ vỏ bưởi Da Xanh (Citrus maxima (Burn.) Merr.) ở các điều kiện trích ly và cô quay chân không khác nhau. Trên cơ sở này, ảnh hưởng của đặc tính nguyên liện và phương pháp trích ly, điều kiện cô quay chân không để đuổi dung môi (áp suất, độ giảm khối lượng) được khảo sát. Kết quả phân tích cho thấy thực hiện ly trích theo phương pháp tách ép công nghiệp (nguyên liệu tươi, bổ sung ethanol 40⁰ ở tỉ lệ 1:1, w/v, gia nhiệt ở 90⁰C trong thời gian 2 phút) giúp cải thiện chất lượng của dịch trích sau khi đuổi dung môi và giảm chi phí năng lượng khi so sánh với phương pháp thông dụng (trên nguyên liệu khô, ngâm trích, không hoặc có sự hỗ trợ của vi sóng). Song song đó, hiệu quả của chế độ loại dung môi bằng thiết bị cô quay ở áp suất tuyệt đối 160-180 mBar cũng được ghi nhận, đặc biệt với khả năng giúp gia tăng giá trị TPC, TFC, TEAC của dịch trích sau khi loại dung môi. Cô quay cho đến khi mất đi 92,5% khối lượng dịch trích được đề nghị để thu nhận cao chiết có chất lượng tốt nhất.
Thực trạng sản xuất các sản phẩm dạng khô từ cá lóc ở Đồng bằng sông Cửu Long
Authors: Trần Bạch Long , Trúc Trần Thanh , Mười Nguyễn Văn 
Published: September 2021

Mục tiêu của nghiên cứu là tìm hiểu, đánh giá quy trình sản xuất và phân tích chất lượng các sản phẩm dạng khô từ cá lóc có trên thị trường. Nghiên cứu đã điều tra ở hai vùng sản xuất sản phẩm từ cá lóc chủ yếu là huyện Chợ Mới, tỉnh An Giang và huyện Tam Nông, tỉnh Đồng Tháp. Kết quả cho thấy khô và chà bông cá lóc là 2 sản phẩm phổ biến nhất, có 28 hộ sản xuất khô cá lóc và 6 hộ sản xuất chà bông cá lóc trong điều kiện hoạt động ổn định. Cả 2 nhóm sản phẩm đều được chế biến theo phương thức truyền thống, công thức chế biến dựa vào kinh nghiệm, sự đầu tư khoa học kỹ thuật, thiết bị, máy móc, nhà xưởng chưa đồng bộ. Quy mô sản xuất khô cá lóc là lớn hơn và sản xuất phổ biến hơn khi so sánh với chà bông cá lóc. Từ 5 mẫu khô cá lóc và 5 mẫu chà bông trên thị trường, kết quả kiểm tra cho thấy cả 5 mẫu khô cá đều có chỉ tiêu vi sinh vượt hơn mức cho phép, độ hoạt động của nước đều cao hơn 0,75 – giá trị thấp nhất theo TCVN 10734: 2015. Đối với chà bông cá lóc, chất lượng và điều kiện an toàn vệ sinh của các sản phẩm đạt yêu cầu, sản phẩm vẫn có mùi vị tốt, chưa nhận...
Ảnh hưởng của nhiệt độ đến động học quá trình sấy cà chua bi đen (Solanum lycopersicum cv. OG) trong điều kiện chân không
Authors: Ha Ho Thi Ngan , Thủy Nguyễn Minh 
Published: September 2021

Sấy chân không là một phương pháp tiên tiến được sử dụng rộng rãi trong chế biến các sản phẩm rau quả. Trong nghiên cứu này, ảnh hưởng của bốn nhiệt độ sấy khác nhau (40oC, 50oC, 60oC và 70oC) ở mức chân không cố định là -700 mmHg (tương ứng với áp suất tuyệt đối 60 mmHg) đến động học biến đổi tỷ lệ ẩm của trái cà chua bi đen (Solanum lycopersicum cv. OG) đã được khảo sát. Tám mô hình sấy thông dụng (Lewis, Page, Page điều chỉnh, Henderson và Pabis, logarit, hai tham số, hàm mũ hai tham số, Henderson và Pabis điều chỉnh) được kiểm tra để chọn ra mô hình phù hợp. Độ khuếch tán ẩm hiệu quả và năng lượng hoạt hóa được tính toán bằng phương trình khuếch tán Fick. Kết quả cho thấy nhiệt độ sấy tăng đã thúc đẩy quá trình sấy chân không diễn ra nhanh hơn và mô hình logarit được chứng minh là phù hợp nhất với các dữ liệu thực nghiệm trong số tám mô hình thử nghiệm. Giá trị độ khuếch tán ẩm hiệu quả dao động từ 3,9028.10-10 đến 1,7580.10-9 m2/s trong phạm vi nhiệt độ khảo sát. Sự phụ thuộc nhiệt độ của độ khuếch tán ẩm hiệu quả tuân theo phương trình Arrhenius với giá trị năng lượng hoạt hóa là 38,69 kJ/mol trong khoảng nhiệt độ 40-70oC.
Ứng dụng công nghệ UAV (drones) theo dõi và hỗ trợ cảnh báo sớm dịch hại vùng canh tác lúa tỉnh Sóc Trăng
Authors: Tuấn Võ Quốc , Nguyễn Tấn Lợi , Quãng Thị Dal , Quang Trương Chí , Phạm Quốc Việt 
Published: September 2021

Đồng bằng sông Cửu Long là vùng canh tác lúa trọng điểm của cả nước, tuy nhiên việc thâm canh tăng vụ trong nhiều năm đã làm cho tình hình sâu bệnh diễn biến phức tạp. Nghiên cứu được thực hiện nhằm ứng dụng công nghệ máy bay không người lái (UAV - unmanned aerial vehicle) để theo dõi và cảnh báo sớm dịch hại. Nghiên cứu phân tích mối quan hệ giữa mức độ nhiễm dịch hại trên lúa dựa trên chỉ số khác biệt thực vật (NDVI - normalized difference vegetation index), chỉ số khác biệt rìa đỏ (NDRE - normalized difference red edge index), và số liệu điều tra thực địa được thu thập tại thời điểm chụp ảnh. Kết quả phân tích đã phân loại được 4 mức độ nhiễm dịch hại trên lúa: nhiễm dịch hại nặng, nhiễm dịch hại trung bình, nhiễm dịch hại nhẹ và không nhiễm dịch hại với tổng diện tích nhiễm là 11,37 ha. Trong đó, nhiễm nặng chiếm 2,1 ha, nhiễm trung bình chiếm 2,76 ha, nhiễm nhẹ chiếm 6,51 ha và không nhiễm là 12,33 ha. Qua đó cho thấy khả năng ứng dụng công nghệ UAV trong theo dõi và hỗ trợ cảnh báo sớm dịch hại trên cây lúa mang lại nhiều hiệu quả, góp phần nâng cao hiệu quả sản xuất lúa tại tỉnh Sóc Trăng nói riêng và vùng Đồng bằng sông Cửu Long nói chung.