bluuebunny/crossref_metadata_2025_split huggingface dataset:
Readability of packaging of medicinal products available without prescription as assessed by older consumers
Authors: Grzybek Katarzyna 
Published: September 2021

The labeling of the medicinal product packaging plays an important role in communication between entities placing the product on the market and its potential buyers. Moreover, the correct labeling of the packaging can protect the life and health of patient consumers. Due to the above, the labeling of the packaging of a medicinal product is subject to numerous legal regulations and has become the subject of consideration of many scientists.
The aim of the article is to present the results of research on the readability of the packaging of over-the-counter medicinal products as assessed by older consumers. The research was carried out using a questionnaire throughout Poland. 400 respondents took part in the survey aged 60 and over.
Evaluation of Quality Assurance Indicators and Contamination Rate in Blood Culture
Authors: ÖKSÜZ Şükrü , DÖNMEZ Betül , KESKİN Banu , MEMİŞ Nagihan , KARAMURAT Zeynep Dilara , ÇALIŞKAN Emel , ÖZTÜRK Cihadiye , ŞAHİN İdris 
Published: September 2021

Objective: Blood culture are of vital importance in patient follow-up, as they enable the identification and production of sepsis causative microorganisms, initiate antibiotic treatment in a timely manner and reduce mortality and morbidity. In this study, it is aimed to evaluate the microorganisms grown in the automated blood culture in the microbiology laboratory of the hospital in terms of quality indicators.
Method: In this study, microorganisms grown from automated blood culture BACTEC-9120 (Becton Dickinson, USA) system from the blood culture samples sent to XXX University Medical Microbiology Laboratory were evaluated retrospectively. For this purpose, the rejection and contamination rate of the samples for which blood culture was requested, the result of Gram staining-final identification compliance, the number of samples sent from a single bottle, and the growth times of microorganisms after incubation were determined.
Result: 5037 blood culture samples were sent to the laboratory from various clinics. 1.7% of these samples were rejected as inappropriate samples. Gram stain-final identification compatibility of blood cultures was investigated and it was determined as 97.8%. The single bottle number of the samples sent was found to be 511. For the 5037 samples included in the study, growth was detected in 20.7%, of which 10.2% were considered as contaminants. In our study, the average breeding time of the factors examined for breeding time was determined to be 30.29 hours.
Conclusion: As conclusion, there is no gold standard to distinguish true pathogens from contaminant agents in blood cultures.
Barriers to Quality Midwifery Care: A Systematic Review and Meta-Synthesis of Qualitative Data
Authors: Ismaila Yakubu , Bayes Sara , Geraghty Sadie 
Published: September 2021

BACKGROUNDSkilled attendance at birth by well-educated and regulated midwives has been identified to reduce maternal and neonatal deaths, however, it has been established that midwives experience barriers that can affect their ability to provide quality care to women and neonates.AIMThis systematic review and meta-synthesis of qualitative data was conducted to investigate the barriers to midwives' ability to provide quality care focusing on African and developed countries.METHODSThe Joanna Briggs Institute process for conducting systematic reviews was followed for this review. Qualitative studies that reported on barriers to midwives' ability to provide quality care were identified by searching the following databases: CINAHL, PubMed, Web of Science, and PsychINFO. Studies reported in English in the last 10 years, within which most participants were midwives and the data reported on barriers to quality care provision by midwives were included in this review.RESULTS813 published research studies were screened, and 11 research papers were included in this review. The meta-synthesis of the findings resulted in six categories: the lack of equipment; inadequate skills and training, lack of space and infrastructure, staff shortages and high workloads, emotional barriers, and workplace culture. Using the Donabedian model of quality care, the barriers were grouped into structure, process, and outcome factors.CONCLUSIONCurrently efforts to improve quality care in African countries focus on structural factors. Efforts to improve quality care in developed countries focus on process factors. In order to improve quality care for women and neonates, efforts need to be focused on all the factors that promotequality care.
Women's Experiences of Care During Pregnancy in a Continuity of Midwifery Care Project in Rural Sweden
Authors: Hildingsson Ingegerd 
Published: September 2021

BACKGROUNDIn antenatal care, health checkups, information, and support is provided to women. Midwifery continuity models of care provide women access to evidence-based care.OBJECTIVEThe aim of this study was to evaluate women's experiences of pregnancy and antenatal care in a continuity of midwifery care project, as well as to gauge the impact the project had on the women's emotional well-being and satisfaction.METHODThis was a cohort study of 226 women enrolled in a continuity of care project in rural Sweden. Profiles of the women were created based on levels of depressive symptoms, worries, fear of birth, and sense of coherence. Data was collected through questionnaires. Odds ratios with 95% confidence intervals were calculated between the clusters for the explanatory variables.RESULTWomen in the two clusters differed in some background characteristics. Women in Cluster 2 had more visits to a doctor. They also received more counseling due to fear of birth and viewed the number of midwives as “too many.” They were less satisfied with the medical, emotional, and overall aspects of their antenatal care. Perceived health, preparedness for birth, and parenthood were rated lower by women in Cluster 2.CONCLUSIONThis study found that women's assessment of their antenatal care was associated with their emotional health. Negative feelings toward changes in pregnancy were often found in women with poorer emotional health, and these women reported being less prepared for birth and parenthood. Thus, it is important to identify women with emotional distress and to provide them additional support and continuity.
Flow Diagnostics in High Rate Gas Condensate Well Using Distributed Fiber-Optic Sensing and its Validation with Conventional Production Log
Authors: Atakishiyev Fuad Aziz , Delfino Alessandro , Cerrahoglu Cagri , Hasanov Zahid , Yusifov Ilkin , Wallace Alex , Mendoza Alberto 
Published: September 2021

Abstract
We introduce a novel Machine Learning (ML) approach for processing distributed fiber-optic sensing (DFOS) data that enables dynamic flow profile monitoring using a fiber-optic e-line cable deployed in a gas condensate well and compare it to a conventional approach. DFOS technology has the potential to provide more efficient and dynamic flow profiles compared to traditional methods, particularly in high rate gas wells where production logs (PL) are recorded at reduced rates to avoid tool lifting.
Distributed acoustic and temperature sensing (DAS & DTS) data were acquired simultaneously while the well was producing ~70 MMSCF/D gas. Conventional PL data was also acquired under the same condition to validate the flow profiling results obtained from DFOS measurements. This paper describes a novel data processing approach where ML based models for pattern recognition were applied to obtain the signatures of different fluid types. Flow profiling is achieved by applying multiple data models to address three key questions for inflow profiling: (1) which zones are producing? (2) what is the phase? and (3) what is the flow rate?
A blind test was set up to avoid results contamination. The processing and interpretation of DFOS data and PL data were carried out independently and results were compared only when the work on both datasets was completed. The comparison demonstrates a good match between two measurements for gas inflow profile with an average error of about 1% in relative gas rate allocation along the four producing perforated intervals. Flow profile in a single-phase gas producing well was accurately determined by DFOS data analysis and the liquid production rate was then re-calculated using condensate-gas ratio (CGR) to obtain liquid and gas production rates at standard surface condition. The well was connected to a test separator during the entire acquisition period, and accurate gas, condensate and water production rates were obtained in real-time at surface condition.
The hybrid processing technique was applied for the first time among our well stock and resulted in accurate gas inflow profiling. To further validate the performance of the presented approach, the authors intend to repeat the test in other high rate gas producing wells, including wells with permanently installed fiber. Multi-disciplinary teamwork involved collaboration between operator and vendor and allowed for efficient operational execution. The result of the risk assessment ensured the selection of the best candidate well ensuring minimum sand production at the optimum production rate, optimization of stationary time for DFOS data acquisition and cable armor erosion model.
Data Analytics Software for Automatic Detection of Anomalies in Well Testing
Authors: Capponi Stefano , Nwachukwu Chiazor 
Published: September 2021

Abstract
This paper will present a software that was developed to diagnose well test data. The software monitors the data, and through a series of algorithms alarms the user in case of discrepancies. This allows the user to investigate possible source of errors and correct them in real time.
Several datasets from previous operations were analyzed and the basic physics governing how a certain datum depends on others were laid out. All the well test data traditionally acquired were put on a matrix, showing the dependencies between each datum and other physical properties that are available - either measured or modelled. Acceptable fluctuations in acquired data were also identified for use as tolerance limits. The software scans through the data as it is acquired and raises an alarm when the identified dependencies are broken. The software also identified which parameter is most likely causing the error.
The software was built based on previous well test data and reports. Subsequently, two field trials were conducted to fine tune the algorithms and allowable data fluctuations. The process of validating the software consisted of: (1) Identifying flagged errors that should have not been flagged (dependencies set too tight); (2) identifying errors that should have been flagged and were not (dependencies set too loose); (3) improving the user interface for ease of use. The results were positive, with several improvements in the error recognition and several discrepancies flagged that would not have been caught by the naked eye. The user interface was also improved, allowing the user to clear error messages and provide input to improve the algorithm. The field trial also demonstrated that the methodology is scalable to other data acquisition plans and to more advanced analytics. The algorithms are simple, allowing the software to be implemented in all operations. More advanced algorithms are likely to depend on job specific data and parameters.
Traditional data acquisition systems used during well test only present the data. Alarms trigger the user's attention only when certain defined operability limits are about to be reached. Being able to confirm that the data is cohesive during the well test prevents a loss of confidence in the results and painful post processing exercises. Moreover, given the algorithms used are based on simple physics, it is easy to deploy the software in any operation.
Protective effect of Bmscs-derived exosomes on testicular ischemia-reperfusion injury in rats
Authors: Tian Hu , Zhang Wan-song , Yang Cheng , Zhou Jun-hao , Zhou Ran-ran , Guo Wen-bin , Liu cundong 
Published: September 2021

Abstract
Background

Testicular Ischemia reperfusion injury(IRI) is a major pathophysiological process of surgical reduction after testicular torsion, and oxidative stress is the main injury factor. However, the role of BMSCs-derived exosomes in testicular IRI and its mechanism have not been reported. In this study, we investigated the protective effect of bone marrow mesenchymal stem cell-derived exosomes against testicular ischemia-reperfusion injury.
Methods

Results: BMSCs were successfully isolated and cultured from rat bone marrow, and exosomes secreted by BMSCs were successfully extracted. In vivo experiment: The testicular torsion rat model was established, and various biochemical indexes of oxidative stress and testicular tissue HE was detected in the sham operation group, testicular torsion group and bone marrow mesenchymal stem cell-derived exosome treatment group. In vitro experiment: H2O2 was used to construct TM4 and GC1 oxidative stress models, and various biochemical indexes of oxidative stress and corresponding pathway proteins were detected in the control group, H2O2 group and bone marrow mesenchymal stem cell-derived exosome treatment group.
Conclusion

BMSCs-derived exosomes can be absorbed by rat spermatogonia and have antioxidant and anti-inflammatory protective effects against testicular ischemia-reperfusion injury。
Efficacy and Safety of Rhomboid Intercostal Block for Analgesia in Breast Surgery and Thoracoscopic Surgery: A Meta-Analysis
Authors: Chen Ruirong , Su Sheng , Shu Haihua 
Published: September 2021

Abstract
BackgroundRhomboid intercostal block (RIB) is a new regional anesthesia technique that provides postoperative analgesia for breast surgery and thoracoscopic surgery. The published papers are not yet fully integrated and do not adequately address the impact and safety of the RIB on postoperative pain.MethodsThe PubMed, Web of Science and Embase were searched from 2016 to 2021 for all available randomized controlled trials (RCTs) that evaluated the analgesic efficacy and safety of RIB after thoracic surgery and breast surgery. Random and fixed-effects meta-analytical models were used where indicated, and between-study heterogeneity was assessed. The primary outcome was Postoperative Numerical Rating Scale (NRS) scores of patients at rest recorded 0-1, 6-8, 24 hours after surgery. The secondary outcomes included rate of postoperative nausea and vomiting (PONV), postoperative fentanyl consumption and presence of complications of the block. ResultsFrom 81 records identified, four studies met our inclusion criteria, including 216 patients (RIB:108 patients; no block: 108 patients). In the primary outcome, RIB group showed significantly lower postoperative NRS at rest at first 0-1 h and 6-8 h (weighted mean difference [WMD] = -1.55; 95% confidence internal [CI] = -2.92 to -0.19; p<0.05), (WMD = -0. 69; 95% CI = -1.29 to -0. 09; p<0. 05). And there was no significant difference between groups in NRS at rest at 24 h (WMD = -0.78; 95% CI = -1.64 to -0.08; p=0.77). Also, RIB group showed significantly lower postoperative NRS of breast surgery and thoracoscopic surgery at 0-1h (WMD = -3.00; 95% CI = -3.13 to -2.87; p<0.01), (WMD = -1.08; 95% CI = -1.98 to -0.18; p<0.05). In the secondary outcome, the analysis also showed RIB group had significant lower of POVN rates (summary relative risk (RR) = 0.212;95%CI = 0.10 to 0.45; p<0. 01) and the postoperative consumption of fentanyl (WMD= -57.52;95%CI = -106.03 to -9.02; p<0. 05). ConclusionThis review shows that RIB was more effective in controlling acute pain after breast surgery and thoracoscopic surgery than general analgesia. And RIB is also a kind of effective and safe bock technology.
The Potential of Invasive and Non-Invasive Vagus Nerve Stimulation To Improve Verbal Memory Performance in Epilepsy Patients
Authors: Mertens Ann , Gadeyne Stefanie , Lescrauwaet Emma , Carrette Evelien , Meurs Alfred , De Herdt Veerle , Dewaele Frank , Raedt Robrecht , Miatton Marijke , Boon Paul , Vonck Kristl 
Published: September 2021

Abstract
Introduction:
It has been demonstrated that acute vagus nerve stimulation (VNS) improves word recognition memory in epilepsy patients. Transcutaneous auricular vagus nerve stimulation (taVNS) has gained interest as a non-invasive alternative to improve cognition. In this prospective randomized cross-over study, we investigated the effect of both invasive VNS and taVNS on verbal memory performance in 15 drug-resistant epilepsy patients.
Methods
All patients conducted a word recognition memory paradigm in 3 conditions: VNS ON, VNS OFF and taVNS. For each condition, patients memorized 21 highlighted words from text paragraphs. Afterwards, the intervention was delivered for 30 s. Immediate recall and delayed recognition scores were obtained for each condition. This memory paradigm was repeated after 6 weeks of VNS therapy in 2 conditions: VNS ON and VNS OFF.
Results
Acute VNS and taVNS did not improve verbal memory performance. Immediate recall and delayed recognition scores were significantly improved after 6 weeks of VNS treatment irrespective of the acute intervention.
Conclusion
The previously described positive effects of invasive VNS on verbal memory performance could not be replicated with invasive VNS and taVNS. An improved verbal memory performance was seen after 6 weeks of VNS treatment, suggesting that longer and more repetitive stimulation of the vagal pathway is required to modulate verbal memory performance.
Growth, Crystal Structure, Hirshfeld Surface Analysis, DFT Studies, Physicochemical Characterization And Cytotoxicity Assays of Novel Organic Triphosphate
Authors: Oueslati Yathreb , Kansız Sevgi , Dege Necmi , Paredes Cristina de la Torre , Lorente Antoni Llopis , Martínez-Máñez Ramón , sta wajda 
Published: September 2021

Abstract
A novel interesting organic-inorganic hybrid compound, named (1-phenylpiperazinium) trihydrogen triphosphate, with the formula (C10H15N2)2H3P3O10 has been obtained by low speed of evaporation at room temperature after using the ion exchange chemical procedure. To carry out a detailed crystallographic structure analysis, single-crystal X-ray diffraction has been reported. In the molecular arrangement, the different entities are held together through N-H…O, O-H…O and C-H…O hydrogen bonds, building up a three dimensional packing. Powder X-ray diffraction analysis is acquired to confirm the purity of the product. The nature and the proportion of intermolecular interactions were investigated by Hirshfeld surfaces analysis. In order to support the experimental results, a density functional theory (DFT) calculation were performed, using the Becke-3-Parameter-Lee-Yang-Parr (B3LYP) function with LANL2DZ basis set, and the data indicate the much agreement between the experimental and the theoretical results. Thus, the physicochemical properties were studied employing a variety of techniques (FT-IR, NMR, UV-Visible and photoluminescence). To get an insight of the possible employment of the present material in biology, cell viability assays were performed.
Durability And Life Prediction of Fly Ash Geopolymer Concrete In Corrosion Environments Caused By Dry And Wet Circulation
Authors: Sun Qi , Li Botao , Wang Yiting , Wang Hui 
Published: September 2021

Abstract
The use of tailings, waste rock, fly ash and slag to prepare geopolymer concrete can effectively solve the problems of land resources occupied by tailings and waste rock, low utilization rate and environmental pollution. Using a dry-wet circulation method, fly ash for a different corrosion solution to geopolymer concrete (referred to as TWGPC) was analysed. Through an appearance change, the corrosion resistance coefficient of the compressive strength, relative dynamic elastic modulus, tensile splitting strength, relative mass and durability were investigated, using scanning electron microscopy (SEM) analysis of the microstructure, The life of TWGPC was predicted based on the GM(1,1) prediction model of grey system theory. The test results show that with an increase in the number of dry-wet cycles, the surface of the specimen crystallizes, cracks, spalls and exhibits other phenomena. The compressive strength corrosion coefficient, relative dynamic elastic modulus, crack tensile strength and relative mass show a trend of increasing first and then decreasing, finally reaching the peak value after 40 cycles. The erosion products generated by the early reaction fill the slurry aggregate pores and improve the strength of TWGPC. In a later stage, a large number of erosion products absorb water and expand, the internal pores of TWGPC are connected, leading to a decrease in strength. Cl- inhibits the corrosion of SO42- in concrete and improves the durability of concrete.
Extranodal Natural Killer/t-cell Lymphoma Nasal Type With Extensive Ocular Tissue Involvement: A Case Report
Authors: Han Ruoan , Jiang Yang , Bian Ailing , Ye Junjie 
Published: September 2021

Abstract
BackgroundTo report a rare case of extranodal natural killer/T-cell lymphoma (ENKTL), nasal type related to extensive ocular tissue, including conjunctiva, ciliary body, vitreous and retina. Case presentationA 52-year-old woman who had been treated by radiotherapy for ENKTL, nasal type in the right nasal cavity presented with a dramatic deterioration of vision in right eye. Physical and accessary examination showed extensive ocular tissue related, including conjunctiva, ciliary body, vitreous and retina. Vitreous specimen and conjunctiva biopsy revealed the presence of ENKTL, nasal type in the right eye. She was treated with systemic and ophthalmic chemotherapy, her ocular symptoms significantly improved, and systemic condition remained stable 7 months after the diagnosis.ConclusionsExtranodal natural killer/T-cell lymphoma, nasal type is an aggressive disease and may relate extensive ocular tissue and course dramatic vision deterioration. It is important to observe ocular related and begin aggressive combined therapy as early as possible after diagnosis.