bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioinformatic analysis of methyltransferase-like protein family reveals clinical and functional outcomes in human cancer
Authors: Campeanu Ion , Jiang Yuanyuan , Liu lanxin , Pilecki Maksymilian , Najor Alvina , Cobani Era , Manning Morenci Manning Morenci , Yang Zeng-Quan 
Published: January 2021

Abstract
Human methyltransferase-like (METTL) proteins transfer methyl groups to nucleic acids, proteins, lipids, and other small molecules, subsequently playing important roles in various cellular processes. In this study, we performed integrated genomic, transcriptomic, proteomic, and clinicopathological analyses of 34 METLLs in a large cohort of primary tumor and cell line data. We identified a subset of METTL genes, notably METTL1, METTL7B, and NTMT1, with high frequencies of genomic amplification and/or up-regulation at both the mRNA and protein levels in a spectrum of human cancers. Higher METTL1 expression was associated with high-grade tumors and poor disease prognosis. Loss-of-function analysis in tumor cell lines indicated the biological importance of METTL1, an m7G methyltransferase, in cancer cell growth and survival. Furthermore, functional annotation and pathway analysis of METTL1-associated proteins revealed that, in addition to the METTL1 cofactor WDR4, RNA regulators and DNA packaging complexes may be functionally interconnected with METTL1 in human cancer. Finally, we generated a crystal structure model of the METTL1-WDR4 heterodimeric complex that provides the basis for further development of novel inhibitors. Our results provide a framework for further study of the functional consequences of METTL alterations in human cancer and for development of small inhibitors that target cancer-promoting METTLs.
Nickel Nanoparticles Immobilized on a Porous Triazine-Thiourea-Sulfonamide as an Efficient Heterogeneous Catalyst for Reduction of Carbonyl Compounds
Authors: Rahimi Abumuslim , Ghorbani-Vaghei Ramin , Alavinia Sedigheh 
Published: January 2021

Abstract
In order to investigate the role of silica template, polymers and nickel nanoparticles on the reduction of aldehydes/ketones, a novel porous triazine-thiourea-sulfonamide polymeric organic support (TTSA) was prepared via in-situ polymerization of melamine (1,3,5-triazine-2,4,6-triamine), thiourea and benzene-1,3-disulfonyl chloride in the presence of silica nanoparticles as a template led to the synthesize silica TTSA nanocomposite. Next, after removal of the template, the nanocomposite was transformed into mesoporous poly triazine-thiourea-sulfonamide. Ni nanoparticles (Ni NPs) were then decorated on the designed mesoporous polymer support and the resulting TTSA@Ni NPs nanospheres were employed as heterogeneous catalyst in the construction of alchohols from reduction of aldehydes/ketones using formic acid/triethyl amine as a reducing agent in water as solvent. The catalyst is low-cost, non-toxic, and can be reused for several catalytic cycles without decreasing the activity.
Could Microparticles and PD1 Interplay Add More Effects on Treatment Outcomes of Multiple Myeloma? A Prospective Controlled Study
Authors: Zahran Asmaa , Zahran Zeinab Albadry , Rayan Amal 
Published: January 2021

Abstract
Background: Although multiple myeloma (MM) is still considered as an incurable disease by current standards, the development of several combination therapies, and immunotherapy approaches has raised the hope towards transforming MM into an indolent, chronic disease, and possibly achieving a cure.Objectives: We tried to shed light on the expression of PD1 and different Microparticles (MPs) in MM and their interplay as a mechanism of resistance to standardized treatments, in addition, find their associations with prognostic factors of MM.Methods: thirty patients with newly diagnosed and chemotherapy naïve active MM, along with 20 healthy participants of comparable age and sex were recruited, after diagnosis of MM; blood samples were collected from both patients and controls for flow cytometric detection of CD4+, CD8+, CD4+PD1+, and CD8+PD1+ T cells, total MPs, CD138+ MPs, and platelet MPs. Results: MM patients had statistically significant higher levels of TMPs, CD138+MPs compared to their controls, while PMPs exhibited no significant difference between both groups. Statistically significant higher percentages of CD8+, PD1CD8+, PD1CD4+T cells were detected in patients compared to controls, while the latter group had a significantly higher percentage of CD4+T cells than MM patients, patients who didn't achieve complete response, had significantly higher percentages of PMPs, CD138+MPs, PD1+CD8+, PD1+CD4+, and CD8+T cells (cutoff values= 61, 10.6, 13.5, 11.3 & 20.1 respectively), (p-values=0.002, 0.003, 0.017, 0.001 & 0.008 respectively).Conclusion: Microparticles and PD1 expressions were associated with proliferative potential and resistance to Bortezomib-based treatments, our results suggested that they played a crucial role in myeloma progression.
Enhancement of Neel Relaxation at Magnetic Heating Performance of Iron Oxide Nanoparticles&nbsp;
Authors: Can Musa , Bairam Chasan , Aksoy Seda , Kuruca Serap , Aktaş Zerrin , Öncül Mustafa 
Published: January 2021

Abstract
The study is based on understand the titanium (Ti) doping effect to enhance the Neel relaxation at magnetic heating performance of magnetite (Fe3O4). Ti doped magnetite ((Fe1-x,Tix)3O4; x= 0.02, 0.03 and 0.05) superparamagnetic nanoparticles were synthesized via sol-gel technique. The analyses were performed for (Fe1-x,Tix)3O4 and core-shell (SiO2 coated (Fe1-x,Tix)3O4) nanoparticles in order to understand the influence of silica coating on the magnetic properties of nanoparticles. The target of study to enhance the Neel relaxation mechanism on magnetic heating. The interparticle spacing and Ti amount were two parameters that we focused on the study. The results provided that coating with SiO2 has no specific effect on heating performance of (Fe1-x,Tix)3O4 nanoparticles. While the increase in temperature (ΔT) under 150 kHz RF signal reached up to 22oC in 10 minutes for SiO2 coated (Fe0.97,Ti0.03)3O4 nanoparticles, which was very close value of uncoated Fe3O4 nanoparticles.
Ventilator-Associated Pneumonia is Linked to a Worse Prognosis Than Community-Acquired Pneumonia in Children
Authors: Hernandez Maria , Girona-Alarcon Mònica , Bobillo-Perez Sara , Urrea Mireia , Sole-Ribalta Anna , Balaguer Mònica , Cambra Francisco-José , Jordan Iolanda 
Published: January 2021

Abstract
BackgroundAround 12-20% of patients with community-acquired pneumonia (CAP) require critical care. Ventilator-associated pneumonia (VAP) is the second cause of nosocomial infection in Paediatric Intensive Care Units (PICU). As far as we know, there are no studies comparing both types of pneumonia in children, thus it remains unclear if there are differences between them in terms of severity and outcomes. ObjectiveThe aim was to compare clinical and microbiological characteristics and outcomes of patients with severe CAP and VAP.MethodsA retrospective descriptive study, including patients diagnosed of VAP and CAP, with a positive respiratory culture and under mechanical ventilation, admitted to the PICU from 2015 to 2019.Results238 patients were included; 163 (68.4%) with CAP, and 75 (31.5%) with VAP. Patients with VAP needed longer mechanical ventilation (14 vs. 7 days, p<0.001) and more inotropic support (49.3 vs. 30.7%, p=0.006). Patients with VAP had higher mortality (12 vs. 2.5%, p=0.005).Enterobacteriaceae were more involved with VAP than with CAP (48 vs. 9%, p<0.001). Taking into account only de non-drug sensitive microorganisms, patients with VAP tended to have more multidrug-resistant bacteria (30 vs. 10.8%, p=0.141) than patients with CAP. ConclusionPatients with VAP had worse prognosis than patients with CAP, needing longer mechanical ventilation, more inotropic support and had higher mortality. Patients with VAP were mainly infected by Enterobacteriaceae and had more multidrug resistant microorganisms than patients with CAP.
An Autocorrelation Modeling Method for Oxygen Saturation Measurement During Low Perfusion
Authors: Tan Shuangping , Wei Jie , Chen Hao , Zhang Tong , Wu Xiali , Deng Youfeng , Zuo Hongbin 
Published: January 2021

Abstract
Background: SpO2 is a widely used estimation of oxygen saturation owing to its convenient usage and low cost. However, SpO2 determination under low perfusion condition is severely affected by noise.Methods: In this paper, an autocorrelation modeling method for the oxygen saturation measurement during low perfusion is presented. The proposed method mainly contains two steps: calculating the autocorrelation of the photoplethysmography (PPG) signals and modeling for the parameter calculation. The autocorrelation of the PPG signals can suppress the noise and extract pulse waves from low perfusion signals. The model can realize the calculation of SpO2 with the autocorrelation signals. Results: Experiments showed that the new method had a good accuracy and stability under low perfusion condition (perfusion index (PI)<=0.2%), and it was also motion-tolerant. Meanwhile, the new method showed a good performance for the oxygen saturation measurement under the condition of lower perfusion(PI=0.1%).Conclusions: The new method could realize the calculation of SpO2 by little computation and high efficiency without extra hardware. It has strong potential in real-time clinical use.
Low-Resolution ADCs for Two-Hop Massive MIMO Relay System under Rician Channel
Authors: Yu Shujuan , Liu Xinyi , Cao Jian , Zhang Yun 
Published: January 2021

Abstract

Advantages of the system in this PaperThis paper investigates the uplink of a two-hop massive Multi-input Multi-output (MIMO) relaying system with low-resolution Analog-to-Digital Converters (ADCs) at both relays. Significantly different from previous work, we design a two-hop MIMO system to shorten the distance between each hop, so that there will be Line-of-Sight (LOS) path between relays. This allows signals to be transmitted under Rician channels instead of Rayleigh channels and thus increases the sum achievable rate. Second, we apply low-resolution ADCs at both relays of the system to reduce the energy burden. The main work of this paperThe main work of this paper is as follows. First, assuming the Channel State Information (CSI) is perfect, we use the higher-order statistics to derive the closed-form expression of the uplink sum achievable rate of the two-hop low-resolution ADCs massive MIMO relay system under one-hop Rayleigh channels and two-hop Rician channels. Next, supposing that the number of antennas tends to infinity, we derive the law of power scaling and further achieve the asymptotic closed-form expressions and the asymptotic values under different power scales. Next, we verify the correctness of theoretical analysis with numerical simulation results, and compare the results under one-hop Rayleigh channels and two-hop Rician channels. Finally, we conclude that transmitting signal under two-hop Rician channels can achieve a lower sum achievable rate compared with transmitting under one-hop Rayleigh channels, which means it's more effective to apply two-hop Rician MIMO system. Besides, we conclude that deploying low-cost and energy-efficient low-resolution ADCs at a large-scale relay system can improve the energy efficiency and achieve a fairly considerable sum achievable rate at the same time.
Formation of Perfusion Defects in Lymph Nodes During the Early Stage of Metastasis&nbsp;
Authors: Yamaki Teppei , Sukhbaatar Ariunbuyan , Kikuchi Ryohei , Sakamoto Maya , Mori Shiro , Kodama Tetsuya 
Published: January 2021

Abstract
A perfusion defect in metastatic lymph nodes (LNs) can be visualized as a localized area of low contrast on contrast-enhanced CT, MRI or ultrasound images. Hypotheses for perfusion defect include abnormal hemodynamics in neovascular vessels and decrease in blood flow in pre-existing blood vessels in the parenchyma due to compression of tumor growth in the LNs. However, the mechanism of perfusion defects in LNs during the early stage of LN metastasis has not yet been investigated. Here we show that the formation of a tumor mass with very few microvessels was associated with the development of a perfusion defect in the non-enlarged LN at the early stage of LN metastasis. We found in a mouse model of LN metastasis induced using non-keratinizing tumor cells that during formation of the perfusion defect in non-enlarged LN, the number of blood vessels £ 50 mm in diameter decreased, while the volume of existing blood vessels >50 mm in diameter increased using contrast-enhanced high-frequency ultrasound and contrast-enhanced micro-CT imaging systems with a maximum spatial resolution of > 30 mm. Furthermore, we found that tumor angiogenesis and pO2 changes in the metastatic LN were not observed. Our results demonstrate that the perfusion defect appear to be a specific form of tumorigenesis in the LN as vascular-rich organ at the early stage of metastasis. We anticipate a perfusion defect on ultrasound, CT or MRI images to be used as an indicator in the non-enlarged LN at the early stage of LN metastasis.
The Association Between Vitamin D and Acute Rejection in Human Kidney Transplantation: A Systematic Review and Meta-analysis Study
Authors: Mirzakhani Mohammad , Mohammadkhani Sheyda , Hekmatirad Shirin , Aghapour Soudabeh , Gorjizadeh Negar , Shahbazi Mehdi , Mohammadnia-Afrouzi Mousa 
Published: January 2021

Abstract
Background: Vitamin D (VitD) deficiency is associated with several diseases such as multiple sclerosis, rheumatoid arthritis, respiratory infection, and so forth. In the field of transplantation (kidney transplantation), some studies reported that patients with VitD deficiency are of increased chance of acute rejection, but other studies did not show such a chance. On the other hand, since VitD is a modulatory factor and can reduce the inflammatory response, understanding the exact role of it in transplantation may contribute to tolerance condition in these patients.Methods: The electronic databases, including PubMed, Scopus, Embase, ProQuest, Web of Science, and Google Scholar, were searched for eligible studies. In general, 14 studies with a total of 4,770 patients were included in this meta-analysis. Regarding the methodological heterogeneity, we selected a random-effects combination model. Moreover, OR was chosen as an effect size for this study.Results: After the combination of 14 studies, we showed that patients in the VitD-deficient group had an 82% increased chance of acute rejection compared with patients in the VitD-sufficient group, and this effect was significant (OR 1.82; 95% confidence interval [CI] [1.29, 2.56]; I2 = 52.3%). This result was significant, and, regarding the narrow CI, it can be a conclusive result. Study quality and gender variables were the main sources of inconsistent results in the primary studies. Moreover, using meta-regression, we showed that VitD deficiency (independent from the estimated glomerular filtration rate (eGFR) of patients) increased the chance of acute rejection.Conclusion: The normal VitD status of patients a few days before and after transplantation can reduce the risk of acute rejection, as it has definite modulatory effects on immune cells.
Resection of pontine cavernous malformation by the full neuroendoscopic telovelar approach
Authors: cai qiang , Ke Yuyong , Ji Baowei , Li Zhiyang , Wang Wenju , Chen Zhibiao , Chen Qianxue , Liu Junhui 
Published: January 2021

Abstract
Introduction: Lesions located in the fourth ventricle and/or pontine tegmentum were treated by telovelar approach under a microscope. However, it is difficult to access upper fourth ventricle from caudal to rostral without removal posterior arch of the atlas due to the vertical working angle of microscope. Neuroendoscope has a good degree of freedom in surgery and can reach this area easily. We tried to remove pontine cavernous malformation by full neuroendoscopic telovelar approach and the results was excellent. Clinical Presentation: Two women presented with dizziness and numbness and were diagnosed as pontine cavernous malformation. The cavernous malformations were removed by a full neuroendoscopic telovelar approach without removal of the posterior arch of the atlas. Conclusion: Neuroendoscope can remedy the flaws of microscopy and can provide greater application for the telovelar approach in pons and fourth ventricle.
Clinical and Social Characteristics of Deliberately Intoxicated Minors Treated in Paediatric Intensive Care
Authors: Kinciniene Odeta , Lesinskaite Auge , Sambaras Rokas , Vankeviciene Ramune , Dervinyte-Bongarzoni Asta , Lesinskiene Sigita 
Published: January 2021

Abstract
Background. The aim of the study was to determine the clinical and social characteristics of minors using alcohol and drugs for inebriation, and the same for those using them for suicide.Methods. This study includes an analysis of case histories of adolescents hospitalized in the Pediatric Intensive Care Unit because of acute alcohol or/and drug intoxication in 2014–2016. Two groups (group I: inebriation, and group II: suicide) were compared on age, sex, severity of intoxication, used substances, presence of other self-harm evidence, and social status.Results. A total of 390 cases were registered: 78.21% in Group I and 21.79% in Group II. The Glasgow-Coma-Scale scores showed that patients from Group I were more severely intoxicated, with an average score of 11.47, whereas patients from Group II averaged 13.45 (P < 0.001). Self-harm was more prominent among minors from Group II, with an incidence of up to 65.09%. The most common substance used to become inebriated was alcohol (72.79%), and for committing suicide was medication (88.24%). Patients who were living in children’s care homes composed 13.33% of all cases included into the study, despite the low frequency of these minors in Lithuania (0.8%).Conclusions. The substance used for deliberate intoxication was mostly alcohol. Minors experiencing inebriation were hospitalized in worse clinical condition in comparison to those who had attempted suicide. Other signs of self-harm were significantly more common among suicidal minors. Living in children’s care homes is a possible risk factor for deliberate intoxication among young people in Lithuania.
A Predict Model to Evaluate the Level of HBV-DNA for the Patients With Chronic Hepatitis B Virus (CHB) in Clinic: a Cross-sectional Study
Authors: Zheng Jinli , Wan Juan , Jiang Chenhao , Huang Yang , Pu Xingyu , Jiang Li 
Published: January 2021

Abstract
Background: The previous studies showed the correlation between HBsAg and serum HBV DNA levels were weak or missing. And the relationship of HBeAg and HBV DNA levels was lack.Objective: The study aims to investigate the correlation between HBeAg and HBV DNA levels, and to find an alternative tool to evaluate the HBV DNA levels for clinicians.Methods: We enrolled 1020 patients in this cross-sectional study. We divided the patients into four groups as: HBeAg positivity and negativity groups, high and low HBV DNA levels groups. Further, as to the levels of HBV DNA, we performed subgroups’ in HBeAg-positive and HBeAg-negative groups.Results: The levels of ALT, ALB and HBeAg were the independent factors for the serum HBV DNA in CHB patients. The predict model for the patients with HBeAg-positive was: M1 (high HBV DNA levels) = 1.412 × (1 for HBeAg-positive >16.15 S/CO or 0 for others) + 0.004 × (1 for ALT > 42.5 IU/L or 0 for others) −0.029 × (1 for ALB > 25.5 g/L or 0 for others) + 0.779, and the AUC was 0.606. And the predict model of patients with HBeAg-negative was: M2 (low levels of HBV DNA) = 0.385 − 0.005 × (1 for ALT > 36.5 IU/L or 0 for others) − 0.006 × (1 for TB > 11.15 umol/L or 0 for others), and the AUC was 0.609.Conclusion: HBeAg was an independent risk factor for the patients with HBeAg(+), and when the level of HBeAg was higher than 16.15 S/CO, the patients should have a HBV-DNA test, if not , we should combine with the level of ALT to determine the decision. For the patients with HBeAg(-), we should evaluate the patients to have a HBV-DNA test by the levels of ALT and TB.
Awareness and readiness to use telemonitoring to support diabetes care among care providers at teaching hospitals in Ethiopia: An institution-based cross-sectional study
Authors: Seboka Binyam Tariku , Yilma Tesfahun Melese , Birhanu Abraham Yeneneh 
Published: January 2021

Abstract
Background. Telemonitoring(TM) has great potential in the management of chronically ill patients and could help to improve the quality of the patient's life while reducing healthcare costs and care providers' overload. It is important to assess the keenness level of care providers to use and maximize benefit of using technologies in chronic care. This survey aimed to assess the awareness and readiness of care providers to support diabetes patients through TM technology. Methods. An institution-based cross-sectional quantitative survey was conducted by using a pretested self-administered questionnaire on 423 study participants at teaching hospitals in northwest Ethiopia. Data entry and analysis were done using Epi-data version 4.6 and STATA version 14 software, respectively. The mean, percentage, and standard deviation were calculated to describe the characteristics of participants. A binary logistic regression analysis method was used to identify factors associated with awareness. The ordinal logistic regression analysis method was used to identify factors associated with readiness, however, the partial proportional odds model was fitted due to violation of the proportional assumption. Result. A total of 406 participants (69.7%, n= 283 nurses and 30.3%, n=123 physicians) were completed survey. A high proportion of respondents owned a computer (66%) or a smartphone (80%). Overall, 38.7% of Participants have heard about TM, when it came to readiness, the majority of the study participants, 321(25.1%) and 121(65.5%) have average and low readiness towards TM, respectively. The result of regression analysis show that the participant’s technical skills, access to basic technologies, and attitude were significantly associated with both outcome variables.Conclusion. The findings of this survey revealed low awareness and readiness of participant’s towards TM. However, this study suggests the need of improving participant's attitudes, access to smartphones and computers, and technical skills to fill this gap.