bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole Genome and Exome Sequencing Reference Datasets from A Multi-center and Cross-platform Benchmark Study
Authors: Zhao Yongmei , Fang Li Tai , Shen Tsai-wei , Choudhari Sulbha , Talsania Keyur , Chen Xiongfong , Shetty Jyoti , Kriga Yuliya , Tran Bao , Zhu Bin , Chen Zhong , Chen Wangqiu , Wang Charles , Jaeger Erich , Meerzaman Daoud , Lu Charles , Idler Kenneth , Zheng Yuanting , Shi Leming , Petitjean Virginie , Sultan Marc , Hung Tiffany , Peters Eric , Drabek Jiri , Vojta Petr , Maestro Roberta , Gasparotto Daniela , Kõks Sulev , Reimann Ene , Scherer Andreas , Nordlund Jessica , Liljedahl Ulrika , Foox Jonathan , Mason Christopher , Xiao Chunlin , Xiao Wenming 
Published: February 2021

AbstractWith the rapid advancement of sequencing technologies in the past decade, next generation sequencing (NGS) analysis has been widely applied in cancer genomics research. More recently, NGS has been adopted in clinical oncology to advance personalized medicine. Clinical applications of precision oncology require accurate tests that can distinguish tumor-specific mutations from errors or artifacts introduced during NGS processes or data analysis. Therefore, there is an urgent need to develop best practices in cancer mutation detection using NGS and the need for standard reference data sets for systematically benchmarking sequencing platforms, library protocols, bioinformatics pipelines and for measuring accuracy and reproducibility across platforms and methods. Within the SEQC2 consortium context, we established paired tumor-normal reference samples, a human triple-negative breast cancer cell line and a matched normal cell line derived from B lymphocytes. We generated whole-genome (WGS) and whole-exome sequencing (WES) data using 16 NGS library preparation protocols, seven sequencing platforms at six different centers. We systematically interrogated somatic mutations in the paired reference samples to identify factors affecting detection reproducibility and accuracy in cancer genomes. These large cross-platform/site WGS and WES datasets using well-characterized reference samples will represent a powerful resource for benchmarking NGS technologies, bioinformatics pipelines, and for the cancer genomics studies.
APOBEC Mutagenesis is Concordant Between Tumor and Viral Genomes in HPV Positive Head and Neck Squamous Cell Carcinoma
Authors: Faden Daniel L , Kuhs Krystle A. Lang , Lin Maoxuan , Langenbucher Adam , Pinheiro Maisa , Yeager Meredith , Cullen Michael , Boland Joseph F. , Steinberg Mia , Bass Sara , Lewis James S. , Lawrence Michael S , Ferris Robert L , Mirabello Lisa 
Published: February 2021

AbstractAPOBEC (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like) is a major mutagenic source in human papillomavirus positive oropharyngeal squamous cell carcinoma (HPV+ OPSCC). Why APOBEC mutations predominate in HPV+OPSCC remains an area of active investigation. Prevailing theories focus on APOBECs role as a viral restriction agent. APOBEC-induced mutations have been identified in both human cancers and HPV genomes, but whether they are directly linked in HPV+OPSCCs remains unknown. We performed sequencing of host somatic exomes, transcriptomes and HPV16 genomes from 79 HPV+ OPSCC samples, quantifying APOBEC mutational burden and activity in both the host and virus. APOBEC was the dominant mutational signature in somatic exomes. APOBEC vulnerable PIK3CA hotspot mutations were exclusively present in APOBEC enriched samples. In viral genomes, there was a mean (range) of 5 (0-29) mutations per genome. Mean (range) of APOBEC mutations in the viral genomes was 1 (0-5). Viral APOBEC mutations, compared to non-APOBEC mutations, were more likely to be low-variant allele frequency mutations, suggesting that APOBEC mutagenesis is actively occurring in viral genomes during infection. Paired host and viral analyses revealed that APOBEC-enriched tumor samples had higher viral APOBEC mutation rates (p=0.028), and APOBEC-associated RNA editing (p=0.008) suggesting that APOBEC mutagenesis in host and viral genomes are directly linked. Using paired sequencing of host somatic exomes, transcriptomes, and viral genomes from HPV+OPSCC samples, here, we show concordance between tumor and viral APOBEC mutagenesis, suggesting that APOBEC-mediated viral restriction results in off-target host-genome mutations. These data provide a missing link connecting APOBEC mutagenesis in host and virus and support a common mechanism driving APOBEC dysregulation.
The coronavirus pandemic, short-term employment support schemes and undeclared work: some lessons from Europe
Authors: Williams Colin C. , Oz-Yalaman Gamze 
Published: February 2021

PurposeThe temporary enforced closure of businesses in response to the coronavirus pandemic has resulted in governments in Europe and beyond offering short-term financial support to the businesses and workers affected. The purpose of this paper is to evaluate a group of workers unable to benefit from the short-term job retention schemes and support to the self-employed made available by governments, namely, those whose paid work is comprised wholly of undeclared work, and how this could be addressed.Design/methodology/approachTo identify those whose paid work is entirely undeclared, a Eurobarometer survey of undeclared work in Europe is reported conducted in September 2019, just prior to the pandemic, and involving 27,565 face-to-face interviews in 28 European countries.FindingsThe finding is that the paid work of one in every 132 European citizens is comprised wholly of undeclared work, and these workers are concentrated in non-essential businesses and activities severely affected by the lockdown. These workers whose paid work is comprised wholly of undeclared work are significantly more likely to be widowed or divorced/separated, living in households with three or more adults, without children and most of the time have financial difficulties in making ends meet.Practical implicationsGiven that businesses and workers in the undeclared economy are largely unable to work under lockdown, it is argued that providing access to short-term financial support, through a regularisation initiative based on voluntary disclosure, would not only provide the income support these workers need but also bring them out of the shadows and put them on the radar of the state authorities, thus transforming undeclared work into declared work.Originality/valueThis paper shows how in the current or repeat lockdowns, the short-term financial support made available by governments can be used to transform undeclared work into declared work.
Enhancing zakat compliance through good governance: a conceptual framework
Authors: Sawmar Abdulsalam Ahmed , Mohammed Mustafa Omar 
Published: February 2021

Purpose
This paper aims to construct a conceptual framework which explains the relationship between governance of zakat institutions and zakat payment compliance by using the organisational legitimacy theory.

Design/methodology/approach
This paper adopts content analysis and a review of multidisciplinary literature that primarily relate to zakat institutions, public governance and compliance behaviour.

Findings
The paper has developed a model, adapted from Abioye et al. (2013), concerning the influence of governance mechanisms on zakat payers’ compliance using trust as a moderator. The model comprises four governance mechanisms which influence zakat payment compliance. The four mechanisms include the board and leadership attributes, transparency and disclosure practices, stakeholder management practices and procedural justice. Trust has a moderating effect on the relationship between governance and zakat compliance.

Research limitations/implications
This model is applicable to regulated zakat systems, where the state has established zakat institutions and regulations for the collection and distribution of zakat, such as Saudi Arabia, Pakistan, Sudan and Malaysia.

Originality/value
This paper proposes a model, based on Abioye et al. (2013), to explain the influence of governance on zakat payment compliance. The novelty of the study is the addition of one new critical variable, procedural justice, to the Abioye et al.’s (2013) framework. Secondly, the model is proposed for regulated zakat jurisdictions.
Italy’s Guardia di Finanza: policing financial crime and domestic security in a changing world
Authors: Nussbaum Brian , Doherty Jeffery Ernest 
Published: February 2021

Purpose
This paper aims to examine the many unusual roles played by the Italian Guardia di Finanza (GdF), and how that unique blend of missions sometimes overlaps as much with conceptions of domestic security as it does with the policing of financial crimes.

Design/methodology/approach
This paper analyzes the agency's historical organization and evolution, legal authorities and changing missions. It uses publicly available government documents and secondary analysis.

Findings
This organization, for historical reasons, was an early version of a hybrid agency that conducted both crime control and national protective missions – policing economic crime, patrolling borders and coasts and attempting to regulate the flows of goods and people into and out of the Italian state.

Research limitations/implications
This analysis uses data collected from annual reports of the Guardia di Finanza, as well as journalistic reporting and scholarly analysis, to assess the changing agency, but it does not use internal sources or direct observation, which could inform future related analyses.

Practical implications
GdF’s unique set of undertakings is particularly relevant as the comparative policing and financial crime literatures grow, and particularly as they continue to overlap with the broader comparative security literature.

Social implications
Policing, and police reform, has been very high profile in recent years, and will continue to be. The unusual structure of Italian policing, and the GdF in particular, have insights that could inform other nations police and policing.

Originality/value
This analysis is designed to describe an unusual case – of financial policing, of policing in general, and of domestic security policy – and illustrating how those issues overlap and relate. National police agencies often have missions that evolve over time, and this is a case study in such evolution.
Comparative analysis of QISMUT+3’s Islamic corporate social responsibility
Authors: Probohudono Agung Nur , Nugraheni Astri , Nurrahmawati An 
Published: February 2021

Purpose
The purpose of this study is to analyze the impact of corporate social responsibility (CSR) disclosure on the financial performance of Islamic banks across nine countries as major markets that contribute to international Islamic bank assets (Indonesia, Malaysia, Saudi Arabia, UAE, Kuwait, Qatar, Turkey, Bahrain and Pakistan or further will be called QISMUT + 3 countries).

Design/methodology/approach
Islamic Social Reporting Disclosure Index (ISRDI) is being used as a benchmark for Islamic bank CSR performance that contains a compilation of CSR standard items specified by the Accounting and Auditing Organization for Islamic Financial Institutions. The secondary data is collected from the respective bank’s annual reports and it used the regression analysis techniques for statistical testing.

Findings
This study found that CSR disclosure measured by ISRDI has a positive effect on financial performance. Almost all ISRDI sub-major categories have a positive effect on financial performance except the “environment” subcategory. The highest major subcategory for ISRDI is the “corporate governance” category (82%) and the “environment” category (13%) is the lowest. For the UAE, Kuwait and Turkey, the ISRDI is positively affected by financial performance and the other countries on this research are not.

Originality/value
This study highlighted the economic benefits of social responsibility practices as a part of business ethics in nine countries that uphold the value of religiosity. Thus, the development of the results of this research for subsequent research is very wide open.
Pedagogy of life beyond happiness
Authors: Hardaker Glenn , Sabki Aishah , Eliza Liyana 
Published: February 2021

Purpose
The purpose of this study is to react to COVID-19 and is intended to transcend the regular thoughts to deeper issues towards humanity and nature. This paper also extends further the article “pedagogy of life beyond extinction” published in the Journal for Multicultural Education. This paper continues this discussion by further inward reflections on the self and the search for ultimate happiness amid the current pandemic that emerged in 2020. The study focusses on a holistic perspective towards a pedagogy that extends further the previous article by focussing on issues of happiness, dialogue and self-awareness.

Design/methodology/approach
This study adopts a reflective and exploratory, style that is an enabler for future research into a pedagogy that is focussed on humanity and nature.

Findings
The conceptual paper explores a holistic perspective towards a pedagogy that considers issues of happiness, dialogue and self-awareness.

Originality/value
This study’s intention is to extend the notion of pedagogy that looks beyond educational institutions in seeking a wider understanding of humanity and nature. The concept of “pedagogy of life beyond happiness” is used as a way to understand levels of the “self” as a way to gain deeper self-awareness. This provides a lens for seeking ultimate happiness.
The impact of perceived brand interactivity on customer purchases. The mediating role of perceived brand fairness and the moderating role of brand involvement
Authors: Gligor David , Bozkurt Sıddık 
Published: February 2021

Purpose
This study aims to investigate the effect of perceived brand interactivity on customer purchases along with the mediating effect of perceived brand fairness. To increase the explanatory power of the model, this study also examines the moderating role of brand involvement.

Design/methodology/approach
An online survey was conducted to measure the constructs of interest. The direct, indirect (mediation) and conditional (moderation) effects were evaluated using linear regression, PROCESS Model 4 and PROCESS Model 59, respectively. Further, the Johnson Neyman (also called floodlight analysis) technique was used to probe the interaction terms.

Findings
The study results indicate that perceived brand interactivity directly and indirectly (via perceived brand fairness) impact customer purchases. The results also reveal that the positive impact of perceived brand interactivity on perceived brand fairness is greater when brand involvement is lower. In the same vein, the positive impact of perceived brand fairness on customer purchases is greater when brand involvement is lower. However, brand involvement does not moderate the impact of perceived brand involvement on customer purchases.

Originality/value
This study examines the effect of perceived brand interactivity on customer purchases (as a customer engagement behavior) while accounting for the mediating role of perceived brand fairness and the moderating role of brand involvement. The results provide noteworthy theoretical and managerial implications.
Experimental study of resin coating to improve the impact strength of fused filament fabrication process pieces
Authors: López Taborda Luis Lisandro , Pérez Eduar , Quintero Daniel , Noguera Polania José Fernando , Zambrano Rodriguez Habib , Maury Heriberto , Esparragoza Ivan E. 
Published: February 2021

Purpose
This study aims to evaluate the impact breaking energy of the parts manufactured by the fused filament fabrication (FFF) method. The evaluation considers the use of the epoxy resin coating, different materials and different printing orientations.

Design/methodology/approach
The authors developed an experimental statistical design using 54 experimental trials. The experiments’ output variable is the impact break energy of the parts manufactured by the FFF method. The input variables for the experiments consist of an epoxy resin coating (XTC-3D®, generic resin and without resin coating), different filament materials (nylon + carbon fiber, polyethylene terephthalate and polycarbonate) and different printing orientations (flat, edge and vertical) used. The authors carried out the tests following the EN ISO 179-1.

Findings
The use of resin coating has a significant influence on the impact energy of parts manufactured using the FFF method. The resin coating increases the impact resistance of parts processed by FFF by almost 100% of the value as compared to the parts without a resin coating. Post-processing is useful on ductile materials and increases impact breaking energy at weak print orientations.

Originality/value
This research opens a new opportunity to improve the mechanical properties of parts manufactured using the FFF method. The use of a resin coating reinforces the parts in weak print orientation.
Use of polymer concrete for large-scale 3D printing
Authors: Krčma Martin , Škaroupka David , Vosynek Petr , Zikmund Tomáš , Kaiser Jozef , Palousek David 
Published: February 2021

Purpose
This paper aims to focus on the evaluation of a polymer concrete as a three-dimensional (3D) printing material. An associated company has developed plastic concrete made from reused unrecyclable plastic waste. Its intended use is as a construction material.

Design/methodology/approach
The concrete mix, called PolyBet, composed of polypropylene and glass sand, is printed by the fused deposition modelling process. The process of material and parameter selection is described. The mechanical properties of the filled material were compared to its cast state. Samples were made from castings and two different orientations of 3D-printed parts. Three-point flex tests were carried out, and the area of the break was examined. Computed tomography of the samples was carried out.

Findings
The influence of the 3D printing process on the material was evaluated. The mechanical performance of the longitudinal samples was close to the cast state. There was a difference in the failure mode between the states, with cast parts exhibiting a tougher behaviour, with fractures propagating in a stair-like manner. The 3D-printed samples exhibited high degrees of porosity.

Originality/value
The results suggest that the novel material is a good fit for 3D printing, with little to no degradation caused by the process. Layer adhesion was shown to be excellent, with negligible effect on the finished part for the longitudinal orientation. That means, if large-scale testing of buildability is successful, the material is a good fit for additive manufacturing of building components and other large-scale structures.
A receptive-responsive tool for customizing occupant's thermal comfort and maximizing energy efficiency by blending BIM data with real-time information
Authors: Birgonul Zeynep 
Published: February 2021

PurposeThe heating, ventilation and air conditioning systems are responsible for a significant proportion of the energy consumption of the built environment, on which the occupant's pursuit of thermal comfort has a substantial impact. Regarding this concern, current software can assess and visualize the conditions. However; integration of existing technologies and real-time information could enhance the potential of the solution proposals. Therefore, the purpose of this research is to explore new possibilities of how to upgrade building information modeling (BIM) technology to be interactive; by using existing BIM data during the occupation phase. Moreover, the research discusses the potential of enhancing energy efficiency and comfort maximization together by using the existing BIM database and real-time information concomitantly.Design/methodology/approachThe platform is developed by designing and testing via prototyping method thanks to Internet of things technologies. The algorithm of the prototype uses real-time indoor thermal information and real-time weather information together with user's body temperature. Moreover, the platform processes the thermal values with specific material information from the existing BIM file. The final prototype is tested by a case study model.FindingsThe outcome of the study, “Symbiotic Data Platform” is an occupant-operated tool, that has a hardware, software and unique Revit-Dynamo definition that implies to all BIM files.Originality/valueThe paper explains the development of “Symbiotic Data Platform”, which presents an interactive phase for BIM, as creating a possibility to use the existing BIM database and real-time values during the occupation phase, which is operated by the occupants of the building; without requiring any prior knowledge upon any of the BIM software or IoT technology.
Low field magnetic stimulation promotes myelin repair and cognitive recovery in chronic cuprizone mouse model
Authors: Wang Zitong , Baharani Akanksha , Wei Zelan , Truong Davin , Bi Xiaoying , Wang Fei , Li Xin‐Min , Verge Valerie M. K. , Zhang Yanbo 
Published: February 2021

AbstractBackgroundMultiple sclerosis (MS) is an inflammatory demyelinating disease featured with neuroinflammation, demyelination, and the loss of oligodendrocytes. Cognitive impairment and depression are common neuropsychiatric symptoms in MS that are poorly managed with the present interventions.ObjectiveThis study aimed to investigate the effects of low field magnetic stimulation (LFMS), a novel non‐invasive neuromodulation technology, on cognitive impairment and depressive symptoms associated with MS using a mouse model of demyelination.MethodsC57BL female mice were fed with a 0.2% cuprizone diet for 12 weeks to induce a chronic demyelinating model followed by 4 weeks of cuprizone withdrawal with either sham or LFMS treatment.ResultsImproved cognition and depression‐like behaviour and restored weight gain were observed in mice with LFMS treatment. Immunohistochemical and immunoblotting data showed enhanced myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein expressions (MOG) in the prefrontal cortex of mice with LFMS treatment, supporting that myelin repair was promoted. LFMS also increased the protein expression of mature oligodendrocyte biomarker glutathione‐S‐transferase (GST‐π). In addition, expression of TGF‐β and associated receptors were elevated with LFMS treatment, implicating this pathway in the response.ConclusionResults from the present study revealed LFMS to have neuroprotective effects, suggesting that LFMS has potential therapeutic value for treating cognitive impairment and depression related to demyelination disorders.