bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the scientific impact of research infrastructures: The
role of current research information systems
Authors: Fabre Renaud , Egret Daniel , Schöpfel Joachim , Azeroual Otmane 
Published: January 2021

Abstract
Research infrastructures (RIs) offer researchers a multitude of research opportunities and services and play a key role in the performance, innovative strength, and international competitiveness of science. As an important part of the generation and use of new knowledge and technologies, they are essential for research policies. Because of their strategic importance and their need for significant funding, there is a growing demand for the assessment of their scientific output and impact. Current research information systems (CRIS) have contributed for many years now to the evaluation of universities and research organizations. Based on studies on the application of CRIS to infrastructures and on a recent French report on the scientometric assessment of RI, this paper analyzes the potential of CRIS and their data models and standards (in particular the international CERIF format and the German RDC model) for the monitoring and evaluation of RIs. The interaction between functional specificities of RI and standards for their assessment is outlined, with reference to their own potential to stimulate and share innovation in the networks located inside and outside RIs. This societal challenge, more than an academic issue, is on the way to further harmonization and consolidation of shared and common RI metrics.
Reinhart Koselleck, la génération 45 et le cas Schmitt
Authors: Hoock Jochen 
Published: January 2021

Resume
Tout au long de sa vie Reinhart Koselleck a insisté sur son appartenance à une génération marquée par la guerre et par une défaite l’une et l’autre inscrites dans une ère concentrationnaire et postconcentionnaire pour laquelle l’expérience primaire est la condition essentielle de tout travail critique de l’historien et du mémorialiste. L’article décrit les étapes de ce parcours intellectuel, qui aurait dû aboutir à la rédaction d’une Historik, une théorie de l’histoire, qu’il n’a jamais écrite. Quelle a été surtout le rôle du débat autour de l’Etat séculier et de l’historicité du droit, tel qu’il s’est développé au cours des années 1950 dans les cercles autour d’Ernst Forsthoff et de Carl Schmitt ? Quelle forme prendra-t-il sous la pression de l’évolution de la société civile au cours des deux décennies suivantes pour se concrétiser finalement dans une réflexion autour de la notion de « travail de mémoire », dont l’enquête sur l’iconographie des monuments aux morts constituera la dernière étape dans le parcours de l’historien.
Turn-Taking and Disagreement: A Comparison of American English and Mandarin Chinese
Authors: Zhu Weihua , Boxer Diana 
Published: January 2021

Abstract
This study compares turn-taking and disagreement behaviors in spontaneous conversations in American English and Mandarin Chinese. The English and Chinese speakers observed some turn-taking rules and employed weak disagreement, but differed in the deployment of extended concurrent speech and strong disagreement. Analysis of the Chinese speakers’ reactions reveals nothing negative. This was confirmed by the Chinese speakers’ viewpoints that were explicitly stated in follow-up interviews, which signal that they perceived the practice of extended concurrent speech and strong disagreement in the collected conversations as politic. Furthermore, the similarities and differences between the speakers’ turn-taking and disagreement behaviors appear to be constrained by contextual factors. This discloses the interplay of context, practice, and perception. These findings can raise our awareness of potential issues that might occur in intercultural encounters and the importance of understanding cross-cultural pragmatic differences to avoid miscommunication.
Bioaccumulation assessment of nanomaterials using freshwater invertebrate species
Authors: Kuehr Sebastian , Kosfeld Verena , Schlechtriem Christian 
Published: January 2021

AbstractBackgroundThe high production volume of engineered nanomaterials (ENMs) may lead to high pressure on the environment, and a scientific assessment of ENMs that bioaccumulate in organisms and biomagnify in the food web is necessary. Within the regulation of chemicals in several jurisdictions, such as the European regulation REACH, the bioconcentration factor is the standard endpoint. The bioconcentration factor is mostly determined by flow-through fish tests. However, nanomaterials tend to agglomerate, which may lead to sedimentation in aquatic environments. The bioavailability of the tested nanomaterials may be thus impaired for pelagic species, including fish, in comparison to benthic or filtrating species. Several risk assessment regulations allow the usage of data gained during tests using invertebrates and such data may allow a waiver of further tests using vertebrates. The aim of this study was to elucidate the potential of different freshwater invertebrate species to be used in laboratory bioaccumulation studies on ENMs and to give some guidance for the use of bioaccumulation endpoints derived from studies using aquatic invertebrate species in the risk assessment process for ENMs.ResultsThe existing literature related to the testing of nanomaterial bioaccumulation with freshwater invertebrates was screened and reviewed to find suitable test species with regard to their ecology and physiology, as well as laboratory test systems allowing to investigate the bioavailability/bioaccumulation of nanomaterials with the respective species. Bivalvia, gastropoda, isopoda, amphipoda, and branchiopoda were reviewed and their suitability for bioaccumulation testing was assessed. Amphipods and bivalves represent worst-case scenarios and show clear advantages to be used as test organisms. However, only amphipods allow the examination of two clearly independent exposure pathways (water and diet).ConclusionAmphipods are suitable test organisms for bioaccumulation testing of ENMs. The results from amphipod bioconcentration and biomagnification tests can be included in a tiered assessment suggested at the end of this study allowing a clear grading of the tested nanomaterials as “bioaccumulative” or “non bioaccumulative.” Due to the worst-case scenario of the amphipod test, this approach may allow a waiver of further vertebrate tests.
Anthropometry of the medial femoral condyle in the Chinese population: the morphometric analysis to design unicomparmental knee component
Authors: Lu Feifan , Sun Xiaowei , Wang Weiguo , Zhang Qidong , Guo Wanshou 
Published: January 2021

Abstract
Background
This study aimed to assess the radii of the distal and posterior articular surfaces of the medial femoral condyle in a Chinese population and provide detailed parameters of the knee joint for the future design of UKA components.

Methods
This study included 500 consecutive Chinese patients who underwent knee MRI from Jan 2019 to Jan 2020. The two most appropriate circles were used to reveal the distal and posterior joint surfaces in the sagittal plane of the MRI images. The radius of the circle representing the distal articular surface in the sagittal plane was measured as R1, and the radius of the posterior articular surface was measured as R2. The distance between the centers of the two rotation circles was recorded as d. An independent t test was used to compare the differences between men and women. The Pearson correlation coefficient was calculated to analyze the correlation between R1 and R2. SPSS v19.0 software was used for statistical analysis.

Results
The average values of R1, R2, R1/R2 and d were calculated. Scatter plots were constructed to show the trend of changes in the radius of the distal and posterior articular surfaces of the femoral condyle. R1, R2 and d differed significantly between men and women (p < 0.05). Correlation analysis showed that R1 was positively correlated with R2 (r = 0.61, p < 0.05).

Conclusions
The data of the radii of the distal and posterior articular surfaces of the medial femoral condyle were provided. In the UKA design, the relationships between the radii of the distal and posterior articular surfaces should be taken into account.
Primitive isolated hydatid cyst of the spleen: total splenectomy versus spleen saving surgical modalities
Authors: Mejri Atef , Arfaoui Khaoula , Ayadi Mohamed Firas , Aloui Badreddine , Yaakoubi Jasser 
Published: January 2021

Abstract
Background
This study aims to describe the clinical features of the isolated primitive splenic hydatid cyst, discuss and compare the different surgical approaches of this uncommon disease.

Methods
This is a descriptive retrospective study carried out over a period of 7 years extending from January 2013 to December 2019 reporting eight cases of isolated primitive splenic hydatid cysts. Data were collected from the register of the general surgery department of the Jendouba regional hospital. Files concerning another associated hydatid localization were excluded. Four patients underwent total splenectomy and four of them underwent different spleen preserving surgical techniques including resection of the protruding dome, partial splenectomy and pericystectomy.

Results
The diagnosis was incidentally made in 50% of cases. The main other revealing complaints are pain in the left upper quadrant of abdomen in 25% of cases and a painless renitent mass in the same quadrant in only 12,5%. None of patients who underwent total splenectomy had fever or sings of postoperative sepsis. Compared to those who had total splenectomy, patients who underwent spleen preserving surgery had a longer average hospital stay (9 vs 6,25 days) related to post-operative complications including abscess in the residual cavity after protruding dome resection in one patient and post-operative haemorrhage in one patient.

Conclusions
The current case series argues in favor of total splenectomy, preferably by laparoscopic route whenever the technical platform allows it, associated with some specific peri-operative therapeutic measures. It seems to be the safest way that helps to avoid post-operative complications of spleen saving surgical modalities. These complications are usually difficult to manage in poor countries with limited technical resources. Total splenectomy guarantees at least a decreased hospital stay, reduced healthcare costs, and the absence of recurrence in highly endemic underdeveloped countries.
“I am called girl, but that doesn’t matter” -perspectives of male nurses regarding gender-related advantages and disadvantages in professional development
Authors: Mao Aimei , Cheong Pak Leng , Van Iat Kio , Tam Hon Lon 
Published: January 2021

AbstractBackgroundExploration of professional development experiences of male nurses can help develop evidence-based strategies to attract males into nursing. The study aims to investigate the advantages and disadvantages of being a male in nursing profession that male nurses and male nursing students experience in their professional development.MethodsA descriptive qualitative research was designed. Purposive sampling was applied and 24 males (12 nursing students and 12 clinical nurses) participated. Semi-structured individual interviews were used in data collection. Thematic analysis was used in data analysis.ResultsProfessional development of male nurses was related to three interplayed identities: a man, a nurse, and a minority. Three themes emerged relating to the professional development of the males: “feeling role strains” “taking perceived advantage of masculine traits” and “taking an egalitarian viewpoint”. There was no clear line between the gender-related advantages and disadvantages as factors influencing professional development can be turned by the males from barriers to facilitators.ConclusionsMale nurses perceive nursing as equally suitable for males and females and make use of masculine traits to thrive in their professional development.
Qualitative evaluation of the Autism Behavior Inventory: use of cognitive interviewing to establish validity of a caregiver report scale for autism spectrum disorder
Authors: Pandina Gahan , Ness Seth , Trudeau Jeremiah , Stringer Sonja , Knoble Naomi , Lenderking William R. , Bangerter Abigail 
Published: January 2021

Abstract
Purpose
The Autism Behavior Inventory (ABI) is an observer-reported outcome scale measuring core and associated features of autism spectrum disorder (ASD). Extensive scale development (reported elsewhere) took place, in alignment with the Food and Drug Administration’s patient-reported outcome guidance, to address the need for instruments to measure change and severity of ASD symptoms.

Methods
Cognitive interviewing was used to confirm understanding and content validity of the scale prior to its use in clinical trials. Respondents were caregivers of individuals with ASD (N = 50). Interviews used a hybrid of the “think-aloud” and verbal probing approach to assess ABI’s content validity and participant understanding of the instrument, including: item clarity and relevance; item interpretation; appropriateness of response scales; and clarity of instructions. Audio-recordings of the interviews were transcribed for qualitative data analysis. The scale was revised based on participant feedback and tested in a second round of interviews (round 1 N = 38, round 2 N = 12).

Results
In total, 67/70 items reached ≥ 90% understandability across participants. Caregivers were able to select an appropriate response from the options available and reported finding the examples helpful. Based on participant feedback, instructions were simplified, 8 items were removed, and 10 items were reworded. The final revised 62-item scale was presented in round 2, where caregivers reported readily understanding the instructions, response options, and 61/62 items reached ≥ 90% understandability.

Conclusions
Cognitive interviews with caregivers of a diverse sample of individuals with ASD confirm the content validity and relevance of the ABI to assess core and associated symptoms of ASD.
Incentivizing appropriate malaria case management in the private sector: a study protocol for two linked cluster randomized controlled trials to evaluate provider- and client-focused interventions in western Kenya and Lagos, Nigeria
Authors: Woolsey Aaron M. , Simmons Ryan A. , Woldeghebriel Meley , Zhou Yunji , Ogunsola Oluwatosin , Laing Sarah , Olaleye Tayo , Kipkoech Joseph , Rojas Bomar Mendez , Saran Indrani , Odhiambo Mercy , Malinga Josephine , Ambani George , Kimachas Emmah , Fashanu Chizoba , Wiwa Owens , Menya Diana , Laktabai Jeremiah , Visser Theodoor , Turner Elizabeth L. , O’Meara Wendy Prudhomme 
Published: January 2021

Abstract
Background
A large proportion of artemisinin-combination therapy (ACT) anti-malarial medicines is consumed by individuals that do not have malaria. The over-consumption of ACTs is largely driven by retail sales in high malaria-endemic countries to clients who have not received a confirmatory diagnosis. This study aims to target ACT sales to clients receiving a confirmatory diagnosis using malaria rapid diagnostic tests (mRDTs) at retail outlets in Kenya and Nigeria.

Methods
This study comprises two linked four-arm 2 × 2 factorial cluster randomized controlled trials focused on malaria diagnostic testing and conditional ACT subsidies with the goal to evaluate provider-directed and client-directed interventions. The linked trials will be conducted at two contrasting study sites: a rural region around Webuye in western Kenya and the urban center of Lagos, Nigeria. Clusters are 41 and 48 participating retail outlets in Kenya and Nigeria, respectively. Clients seeking care at participating outlets across all arms will be given the option of paying for a mRDT—at a study-recommended price—to be conducted at the outlet. In the provider-directed intervention arm, the outlet owner receives a small monetary incentive to perform the mRDT. In the client-directed intervention arm, the client receives a free ACT if they purchase an mRDT and receive a positive test result. Finally, the fourth study arm combines both the provider- and client-directed interventions. The diagnosis and treatment choices made during each transaction will be captured using a mobile phone app. Study outcomes will be collected through exit interviews with clients, who sought care for febrile illness, at each of the enrolled retail outlets.

Results
The primary outcome measure is the proportion of all ACTs that are sold to malaria test-positive clients in each study arm. For all secondary outcomes, we will evaluate the degree to which the interventions affect purchasing behavior among people seeking care for a febrile illness at the retail outlet.

Conclusions
If our study demonstrates that malaria case management can be improved in the retail sector, it could reduce overconsumption of ACTs and enhance targeting of publicly funded treatment reimbursements, lowering the economic barrier to appropriate diagnosis and treatment for patients with malaria.

Trial registration
ClinicalTrials.govNCT04428307, registered June 9, 2020, and NCT04428385, registered June 9, 2020.
Lignin intermediates lead to phenyl acid formation and microbial community shifts in meso- and thermophilic batch reactors
Authors: Prem Eva Maria , Mutschlechner Mira , Stres Blaz , Illmer Paul , Wagner Andreas Otto 
Published: January 2021

Abstract
Background
Lignin intermediates resulting from lignocellulose degradation have been suspected to hinder anaerobic mineralisation of organic materials to biogas. Phenyl acids like phenylacetate (PAA) are early detectable intermediates during anaerobic digestion (AD) of aromatic compounds. Studying the phenyl acid formation dynamics and concomitant microbial community shifts can help to understand the microbial interdependencies during AD of aromatic compounds and may be beneficial to counteract disturbances.

Results
The length of the aliphatic side chain and chemical structure of the benzene side group(s) had an influence on the methanogenic system. PAA, phenylpropionate (PPA), and phenylbutyrate (PBA) accumulations showed that the respective lignin intermediate was degraded but that there were metabolic restrictions as the phenyl acids were not effectively processed. Metagenomic analyses confirmed that mesophilic genera like Fastidiosipila or Syntrophomonas and thermophilic genera like Lactobacillus, Bacillus, Geobacillus, and Tissierella are associated with phenyl acid formation. Acetoclastic methanogenesis was prevalent in mesophilic samples at low and medium overload conditions, whereas Methanoculleus spp. dominated at high overload conditions when methane production was restricted. In medium carbon load reactors under thermophilic conditions, syntrophic acetate oxidation (SAO)-induced hydrogenotrophic methanogenesis was the most important process despite the fact that acetoclastic methanogenesis would thermodynamically be more favourable. As acetoclastic methanogens were restricted at medium and high overload conditions, syntrophic acetate oxidising bacteria and their hydrogenotrophic partners could step in for acetate consumption.

Conclusions
PAA, PPA, and PBA were early indicators for upcoming process failures. Acetoclastic methanogens were one of the first microorganisms to be impaired by aromatic compounds, and shifts to syntrophic acetate oxidation coupled to hydrogenotrophic methanogenesis occurred in thermophilic reactors. Previously assumed associations of specific meso- and thermophilic genera with anaerobic phenyl acid formation could be confirmed.
Synbiotic supplementation with prebiotic Schizophyllum commune derived β-(1,3/1,6)-glucan and probiotic concoction benefits gut microbiota and its associated metabolic activities
Authors: Singh Vineet , Muthuramalingam Karthika , Kim Young Mee , Park Sanggyu , Kim Sung Hong , Lee Jongdae , Hyun Changlim , Unno Tatsuya , Cho Moonjae 
Published: January 2021

AbstractSynbiotics synergistically favors beneficial effects of prebiotics and probiotics towards host metabolic health by modulating gut ecosystem. In this study, we sought to examine the effects of prebiotics (Schizophyllum commune derived β-(1,3/1,6)-glucan), probiotics (concoction made of eight different bacterial strains) and synbiotics (prebiotics + probiotics) on gut microbiota and its associated metabolic functions through 16S rRNA gene sequences analysis. Results showed that probiotics strains used in this study were detected more in the synbiotic and probiotic treatments, while prebiotic dietary intervention increased the total bacterial abundance and metabolisms related to host immune strengthening. Probiotics and synbiotics dietary interventions enhanced similar metabolisms relating to butanediol and s-adenosyl-l-methionine biosynthesis. Probiotics treatment also showed depleted metabolic activities related to SCFA productions, that were not depleted in prebiotics treatment. With varying differential abundance patterns and metabolic activities across the treatments, our results suggest that synbiotic treatment provide more beneficial effects over probiotics and prebiotics.
Preparing for a “dirty bomb” attack: the optimum mix of medical countermeasure resources
Authors: Rump Alexis , Ostheim Patrick , Eder Stefan , Hermann Cornelius , Abend Michael , Port Matthias 
Published: January 2021

Abstract
Background
In radiological emergencies with radionuclide incorporation, decorporation treatment is particularly effective if started early. Treating all people potentially contaminated (“urgent treatment”) may require large antidote stockpiles. An efficacious way to reduce antidote requirements is by using radioactivity screening equipment. We analyzed the suitability of such equipment for triage purposes and determined the most efficient mix of screening units and antidote daily doses.

Methods
The committed effective doses corresponding to activities within the detection limits of monitoring portals and mobile whole-body counters were used to assess their usefulness as triage tools. To determine the optimal resource mix, we departed from a large-scale scenario (60,000 victims) and based on purchase prices of antidotes and screening equipment in Germany, we calculated efficiencies of different combinations of medical countermeasure resources by data envelopment analysis. Cost-effectiveness was expressed as the costs per life year saved and compared to risk reduction opportunities in other sectors of society as well as the values of a statistical life.

Results
Monitoring portals are adequate instruments for a sensitive triage after cesium-137 exposure with a high screening throughput. For the detection of americium-241 whole-body counters with a lower daily screening capacity per unit are needed. Assuming that 1% of the potentially contaminated patients actually need decorporation treatment, an efficient resource mix includes 6 monitoring portals and 25 mobile whole-body counters. The optimum mix depends on price discounts and in particular the fraction of victims actually needing treatment. The cost-effectiveness of preparedness for a “dirty bomb” attack is less than for common health care, but costs for a life year saved are less than for many risk-reduction interventions in the environmental sector.

Conclusion
To achieve economic efficiency a high daily screening capacity is of major importance to substantially decrease the required amount of antidote doses. Among the determinants of the number of equipment units needed, the fraction of the potentially contaminated victims that actually needs treatment is the most difficult to assess. Judging cost-effectiveness of the preparedness for “dirty bomb” attacks is an issue of principle that must be dealt with by political leaders.