bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using Adverse Event Pyramids to Assess Probabilities in Airline Safety Management
Authors: Bitinš Aleksandrs , Maklakovs Juris , Bogdane Ruta , Chatys Rafał , Shestakov Vladimir 
Published: July 2021

Abstract
This article reviews the methods of safety management using Heinrich’s and Bird’s pyramids. The presence of a causal relationship between pyramid levels, as a result of inconsistencies in the activities of an organization and personnel, lead to incidents, and incidents in turn lead to accidents. The existence of such a relationship makes it possible to predict the risk of “top-level” events by reducing risks at the middle and lower levels. A mathematical description of the development process of an undesired aviation event is presented, which makes it possible to evaluate the probability of the successful (or unsuccessful) completion of a transportation task. Also given is an analysis of the development of an aviation accident, based on the example of the crash of a Lufthansa A-320 aircraft on 14 September 1993 at the airport of Warsaw (Poland) while landing in adverse weather conditions.
Aktivitas Antioksidan Ekstrak Etanol Kayu Manis (Cinnamomum burmani) Secara In Vitro / Antioxidant Activities Of Cinnamon (Cinnamomum burmani) In Vitro
Authors: Antasionasti Irma , I Jayanto 
Published: July 2021

ABSTRACT
Cinnamon (Cinnamomum burmani) is a spice that can be used as an additive in food and cakes as well as a pharmaceutical ingredient in the pharmaceutical industry. Therefore, the exploration of cinnamon as a natural antioxidant is highly needed. The study aims is to investigate the antioxidant activity of cinnamon using the DPPH, ABTS radical assay and ferric reducing activity power (FRAP) as well as total phenolic and total flavonoids. Cinnamon was extracted using the maceration technique by ethanol 96% as a solvent and tested for antioxidant activity. The antioxidant activity of DPPH, ABTS, and FRAP that showed by the ethanol extract of cinnamon were 1.939 ± 0.055 ?g/mL; 2,235 ± 0.014 ?g/mL; and 1415.705 ± 38.609 mg of ascorbic acid/gram extract, respectively. The antiradical activity of the ethanol extract of cinnamon was lower than vitamin C, namely 0.554 ± 0.003 ?g/mL (DPPH) and 0.813 ± 0.028 ?g/mL (ABTS). The antioxidant activity provided by the ethanol extract of cinnamon was influenced by the total phenolic content and total flavonoids, respectively 75.685 ± 1.408 % EAG and 60,546 ± 0,670% EK. Cinnamon has very strong antioxidant activity, contains high amounts of total phenolic and total flavonoids so that it has the potential to be a food additive (antioxidant) in the food and pharmaceutical industries.
A case report of pregnant lady with hyperemesis gravidarum that led to osmotic demyelinolysis
Authors: Salim Karattuthodi Mohammed , Saidalavi Ramsiya , Fabin Kainadan , Faris Kizhissery Salman , Vijayan Aswathi 
Published: July 2021

Background:
The fall of serum sodium concentration may happen in hyperemesis gravidarum and subsequently can result into hypotonic hyponatremia. This would cause water to move into the brain and develop cerebral edema manifested with neurologic symptoms. However, adaptive mechanism by brain would lower the cerebral volume to a normal range. On the other hand, rapid correction of chronic hyponatremia would damage the brain cells. The symptoms depicted because of rapid over correction of sodium is known as osmotic demyelination syndrome.

Case Presentation:
The pregnant lady with hyperemesis gravidarum went to severe hyponatremia. And further, she underwent dilatation and evacuation because of the intrauterine fetal death. The normal saline administered to correct the state of hyponatremia caused the patient to be in depression with catatonia and aphasia. The symptoms were correlated with osmotic demyelinolysis and the event was confirmed with magnetic resonance imaging of brain.

Conclusion:
The administration of sodium should be performed with utmost cautions and under the supervision of well-trained healthcare providers. Any sign or symptom of neurological abnormalities observed because of overcorrection should be considered seriously.
Adjuvant radiotherapy for endometrial cancer in a renal transplant patient - a case report
Authors: Tahseen Rabia , Hammad Khan Agha Muhammad , Ahmed Yumna , Ali Nasir 
Published: July 2021

Background:
Treatment of locally advanced endometrial cancer in patients with transplanted pelvic kidney requires precautions because of its anatomical position next to target volumes.

Case Presentation:
We report a case of 42-year-old woman with a right renal transplant for 3 years diagnosed with endometrial cancer for which she underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy. Adjuvant Radiotherapy (RT) was planned through intensity modulated RT (IMRT) with 45 Gy in 25 fractions followed by vaginal brachytherapy (5 Gy × 2 sessions). Planning with IMRT quantified a mean dose of 2 Gy and maximum dose of 10 Gy over the transplanted kidney. This dose was further reduced with a comparative plan of three-dimensional conformal RT (3DCRT), recording a mean dose of 1 Gy and maximum dose of 5 Gy to the transplanted kidney. 3DCRT plan was accepted and delivered. At 2-year follow-up, patient is disease free with normal renal function.

Conclusion:
In the presence of advanced techniques, 3DCRT is still a valid radiation technique to keep the critical organ dose under acceptable dose-volume constraints without compromising the target volume.
1,2-Benzoxathiin-4(3H)-one 2,2-dioxide – an underinvestigated building block with a high synthetic and pharmacological potential: synthesis, chemical properties, biological activity
Authors: Hryhoriv Halyna V. , Lega Dmitry A. , Shemchuk Leonid A. 
Published: July 2021

Aim. To analyze the available literature data on the methods of synthesis, chemical transformations and the biological activity of derivatives containing a sultone core – 1,2-benzoxathiin-4(3H)-one 2,2-dioxide – and to show the possibilities of their further use in the construction of new molecular systems with attractive pharmacological properties.
Results and discussion. The most widespread method for the synthesis of 1,2-benzoxathiin-4(3H)-one 2,2-dioxides is the cyclization of salicylic acid derivatives. The known chemical transformations of 1,2-benzoxathiin-4(3H)-one 2,2-dioxides deal with all reaction centers of the heterocyclic fragment of the condensed system – C=O and CH2 groups, SO2–O bond, CH2CO fragment as a whole. It should be noted that the oxathiine nucleus is prone to undergo recyclizations. The use of 1,2-benzoxathiin-4(3H)-one 2,2-dioxides in multicomponent transformations still remains hardly explored. The “abnormal” course of some classical transformations involving 1,2-benzoxathiine 2,2-dioxides is also noteworthy. The study of the pharmacological properties of 1,2-benzoxathiin-4(3H)-one 2,2-dioxide derivatives is scarce and mainly based on their structural similarity to the coumarin core, which led to the study of anticoagulant, antimicrobial and antitumor properties for the sultone derivatives.
Conclusions. The analysis has shown a limited number of studies in each aspect – approaches to the synthesis of 1,2-benzoxathiin-4(3H)-one 2,2-dioxides, their chemical transformations and the study of their pharmacological activity. In addition to a small number of publications on this heterocyclic system, there have been almost no sultone studies in the last 20 years. Taking this into account 1,2-benzoxathiin-4(3H)-one 2,2-dioxide and its derivatives deserve close attention as objects of research for experimental chemistry and pharmacology.
Effectiveness of the Management of Drug-drug Interactions in Inpatients through the Drug Interaction Warning System and Clinical Pharmacy Activity at Lao Cai General Hospital
Authors: Thi Thuy An Nguyen , Van Thinh Pham , Thanh Hai Nguyen , Xuan Bach Nguyen 
Published: July 2021

In prescribing practice for inpatients, quickly detecting pairs of drug-drug interactions (DDIs) and providing prompt management when prescribing is of utmost importance in ensuring safe and rational use of drugs. Subjects and research methods: All prescriptions with DDIs warnings for inpatients from 1/1/2021 to 31/3/2021 on the residue reporting system at Lao Cai General Hospital. The research is designed as a cohort study. Results: In 3 months of implementing DDIs surveillance on the system of reporting, there were 214 times of DDIs occurring in 157 inpatients, of which 2 were contraindicated DDIs and 212 severe DDIs. Patients with DDIs have the mean age and number of diseases, respectively: 63.2 ± 17.5 (years) and 4.3 ± 1.87 (diseases). 2 patients with contraindicated DDIs of a clarithromycin-lovastatin pair received direct feedback from pharmacists to agree to cancel the prescription; Patients with severe DDIs are also discussed by pharmacists to agree on the most appropriate management for each patient, such as 77.83% of clinical supervision; 7.08% of replacement medicine; 2.83% of following up more tests; 1.89% of stopping using drugs. Conclusion: The DDIs warning system and clinical pharmacy activity have managed all pairs of DDIs that often occur on inpatients at Lao Cai General Hospital.
Keywords
Drug interaction warning system, clinical pharmacy activities, Lao Cai General Hospital.
References
Determination of the Effect of Soil Particle Size Distribution on the Shear Behavior of Sand
Authors: Afrazi Mohammad , Yazdani Mahmoud 
Published: July 2021

Many geotechnical problems require the determination of soil engineering properties such as shear strength. Therefore, the determination of the reliable values for this parameter is essential. For this purpose, the direct shear test, as one of the oldest tests to examine the shear strength of soils, is the most common way in laboratories to determine the shear parameters of soil. There are far too many variables that influence the results of a direct shear test. In this paper, a series of 10 × 10 cm direct shear tests were carried out on four different poorly graded sands with different particle size distributions to determine their shear behaviors. Four different poorly graded sands with a different median diameter or medium value of particle size distribution (D50) (0.2, 0.53, 1.3, and 2.3 mm) has been selected, and about 40 direct shear tests were conducted. It was concluded that a soil’s friction angle is affected by coarse-grained material. Accordingly, sandy soils with bigger particle sizes record a higher friction angle than soils containing small particles. The investigations also showed that sand with bigger particle sizes has a higher dilation angle. In addition, a non-linear regression analysis was performed to establish the exact relationship between the friction angle of the soil and the characteristics of the soil particles. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.
Democratização da educação básica no município de São Paulo (2013-2016)
Authors: Moschen Nascente Renata Maria , Dias da Silva Vagnum 
Published: July 2021

O objetivo do artigo é analisar a democratização da educação básica no município de São Paulo de 2013 a 2016, na administração do Partido dos Trabalhadores (PT). A abordagem metodológica foi qualitativa e documental. O problema se constituiu na questão: quais seriam alguns dos indicadores de avanços na democratização da educação básica? Foram levantados alguns deles: valorização dos(as) profissionais; elevação da qualidade social pela universalização do acesso e trabalho sistemático para garantia de permanência das mais diversas aprendizagens; incentivo Ã participação e Ã autonomia nas e das escolas e esforço na formulação, aprovação e implantação de políticas democratizantes.Â
Docência, tecnologias e sociedade neoliberal
Authors: Alves de Oliveira Evandro Salvador , Cunha Neto Júlio Henrique , Carivaldo de Miranda Neto Henrique , Cecílio Sálua 
Published: July 2021

Nesta entrevista a temática que envolve educação, tecnologias e sociedade neoliberal é o ponto central de discussão e reflexão. O propósito é trazer Ã tona problematizações sobre as controvertidas relações entre educação e tecnologias na sociedade conduzida pelo capitalismo global e neoliberalismo, além de seus efeitos na produção de subjetividades. Dialogar sobre esse tema é bastante instigante porque, ao olhar a partir de outras dimensões (perspectiva crítica e dialética), é possível desconstruir aspectos instaurados na academia com pontos e contrapontos que oportunizam críticas e debates. Para aprofundar esse campo de conhecimento, foi entrevistado o docente Acir Mário Karwoski (A. M. K.), que se destaca no cenário nacional pelos legados e pelas inúmeras produções científicas que possui.
olhar psicanalítico sobre a inclusão de um aluno com autismo
Authors: Santana de Lima Izabella Lorrayne , Neves Legnani Viviane 
Published: July 2021

O artigo busca fazer uma leitura do processo de inclusão escolar de uma criança com diagnóstico de Transtorno do Espectro Autista (TEA) Ã luz da teoria psicanalítica. Lançar-se-á mão de um estudo de caso que conta com a participação de três professoras e do aluno com diagnóstico de TEA. O estudo de caso foi construído por meio de observação participante e entrevistas com as professoras e a mãe do aluno. Pode-se perceber que as professoras realizam o processo inclusivo de forma ética, respeitando o aluno como sujeito e compreendem que não há a possibilidade de inclusão de forma massificada, não cabendo generalizações acerca do trabalho com base em diagnósticos apresentados.
Ecos do circo social em Uberlândia/MG
Authors: Oliveira Alves Sousa Janaina , Fernandes Miranda Rita de Cassia , Ontañón Barragán Teresa 
Published: July 2021

O presente trabalho de natureza qualitativa descritiva apresenta o panorama do circo social na cidade de Uberlândia/MG (Brasil), por meio de dois projetos sociais. O objetivo foi analisar a visão de seis educadores acerca dos principais desafios, potencialidades e entraves ao desenvolvimento do circo social na realidade brasileira. Os resultados apontaram a relevância da convivência diária e dos vínculos afetivos como elementos fundamentais na construção de relações de confiança e amizade. Além disso, foram identificados como desafios Ã formação dos educadores, a falta de investimento financeiro nos projetos, além da reduzida participação das famílias nas atividades implementadas.
Autorregulação de aprendizagens e o desempenho acadêmico no ensino superior
Authors: De Carvalho Ramos Silva Juana , Fernandes de Carvalho Carolina 
Published: July 2021

Na educação, a autorregulação envolve diferentes aspectos de monitorização, volição e ações direcionadas Ã realização de objetivos. Pretende-se verificar a fiabilidade e a validade de um instrumento de autorregulação da aprendizagem para estudantes do ensino superior e identificar como esta se relaciona com o desempenho acadêmico. Participaram 516 estudantes de Institutos Federais do Brasil que responderam a um questionário on-line. O questionário revelou índices adequados de ajustamento psicométrico e a autorregulação explica significativamente o desempenho acadêmico dos estudantes.
La INFLUENCIA DEL ENTORNO FAMILIAR Y EL TIPO DE FAMILIA EN EL DESARROLLO DEL LENGUAJE EN NIÑOS DE 3 A 5 AÑOS
Authors: Sarmiento-Genovez Alejandra , Lorenzo-Ruiz Alexis , Rondon -Acosta Yoisy , Valdés-Santiago Damian 
Published: July 2021

Resumen: El desarrollo del lenguaje del niño está vinculado de manera directa con el entorno que rodea al niño y su familia. El objetivo fue determinar la relación entre el entorno familiar y el tipo de familia en el desarrollo del área de lenguaje en niños de 3 a 5 años. Referente al método, se método, se aplicaron dos instrumentos de evaluación, el Test de desarrollo psicomotor (TEPSI) y el inventario HOME para la familia. En los resultados existió prevalencia del sexo femenino en los infantes (52.52 %), se evidenció que el promedio de edad de las madres fue 32.21 (DE = 3.92) y el de los padres 34.81 (DE = 3.75), existió índice alto en el nivel de la educación de las madres, siendo el (65.65 %) nivel educativo superior y el padre un predominio el nivel universitario (77, 77 %), en cuanto al tipo de familia se presentó mayor porcentaje de las familias nucleares (44, 45 %), Con respecto a la relación conyugal entre los padres y madres se reportó que el (42.43 %) habitan con padres casados. En cuanto al entorno familiar se detectó nivel moderado de 46 (46.46 %) y en el al área del lenguaje se evidenció un índice alto de (56.56 %) en la categoría de desarrollo normal. Con los resultados que se obtuve en la investigación se pudo determinar conclusiones en base al tema investigado. Como conclusión, se evidenció la relación que hay entre las variables del objetivo, dando como resultado una interacción entre el entorno familiar y el desarrollo del lenguaje del niño (p < 0.001) y el tipo de familia y el desarrollo del lenguaje. (p < 0.01).
recurso de casación y la violación de los principios, derechos y garantías del debido proceso
Authors: Coral Almeida Edgar Alonzo , Coral Robalino Guillermo Esteban 
Published: July 2021

La resolución No.10-2015 dictada por el Pleno de la Corte Nacional de Justicia, publicada en el Registro Oficial No. 563 del 12 de agosto de 2015, es inconstitucional, ya que, para la admisión del recurso de casación exige requisitos de admisibilidad y de forma, no previstos en la ley penal, lesionando el derecho a la tutela judicial efectiva y dejando en estado de indefensión a los recurrentes. Se vulnera el derecho a la tutela judicial efectiva, imparcial y expedita de los derechos, con observación de los principios de inmediación y celeridad, así como, la norma constitucional que dispone que los procesos se sustanciarán mediante el sistema oral, de acuerdo con los principios de concentración, contradicción y dispositivo, instituyendo en la práctica una casación formal sin tomar en cuenta la casación de oficio, por lo que no se considera el principio constitucional de que ‘‘no se sacrificará la justicia por la sola omisión de formalidades’’.
Identifikasi Kemampuan Berpikir Logis Mahasiswa Calon Guru Fisika Menggunakan Instrument TOLT
Authors: Rahmawati Rahmawati , Kurniawan Edy , Nur A. Muafiah 
Published: July 2021

This study aimed to identify the type of reasoning and the level of prospective physics teacher studentsÃ¢â¬â¢ logical thinking ability. This type of research was a field study with a quantitative descriptive method. The test was the technique used in collecting data of this study. The instrument used in this study was the standard test like Test of Logical Thinking (TOLT). This test consists of 10 questions that measured five types of reasoning, namely proportional reasoning, variable control, probabilistic reasoning, correlation reasoning, and combination reasoning. The level of logical thinking ability was distinguished into concrete, transitional, and formal thinking operational. The sample of this study was students of physics teacher candidates at the first-year level, totaling 30 students. ÃÂ All of data was analyzed by quantitative descriptive. In general, students tend to the type of proportional reasoning and controlling variables and less on probabilistic reasoning. Based on the level of logical thinking ability, the results showed that the percentage of 30 students who were in the concrete, transitional, and formal categories, respectively, were 30%, 30%, and 60%. This data becomes the basis for consideration in the development of learning models and learning assessments used in lectures, especially in Department of Physics Education in one of the University in Makassar city, so that they are able to contribute to the development of students' level of logical thinking skills as a provision for the next life.
Penggunaan Pedoman Operasional Alat Peraga Penentuan Luas Daerah Layang Layang dan Luas Daerah Lingkaran Bagi Siswa Sekolah Dasar
Authors: Sarjana Ketut , Amrullah Amrullah , Apsari Ratih Ayu , Junaidi Junaidi 
Published: July 2021

Tujuan penelitian ini untuk mengetahui bagaimana penggunaan pedoman operasional alat peraga penentuan luas daerah ÃÂ Layang-layang dan luas daerah lingkaran untuk siswa sekolah dasar di Kota ÃÂ Mataram. Alat peraga dan pedoman operasionalnya telah dihasilkan melalui penelitian, untuk melihat penggunaan pedoman operasional tersebut dilakukan implementasi di kelas pada pembelajaran geometri mengenai luas daerah Layang-layang dan lingkaran untuk siswa kelas VI SD di Kota Mataram. Pada saat implementasi telah terjadi suasana pandemi COVID 19. Sampel dari penelitian ini adalah siswa SD kelas VI yang ada di Kota Mataram yang tersebar di 9 kelas yakni di wilayah Ampenan 3 kelas, di Mataram 3 kelas dan di Cakranegara sebayak 3 kelas. Kelas-kelas ini dipilih karena telah siap melaksanakan pembelajaran dalam jaringan dan kelas-kelas di setiap wilayah homogen dari segi tempat yang sangat mudah terjangkau dan kemampuan siswa yang hampir sama. Hasil evaluasi menunjukkan bahwa skor rata-rata yang diperoleh dari pasangan tiga kelas di setiap wilayah tidak berbeda secara sigifikan pada taraf signifikansi 5 %. Untuk di wilayan Cakranegara, Wilayan Mataram dan di wilayah Ampenan diperoleh ÃÂ thitung<ÃÂ ttabel = 2,002. Disisi lain ketuntasan yang diperoleh siswa di setiap kelas di setiap wilayah > 80%. Ini berarti bahwa siswa tuntas dalam belajar tentang luas daerah layang-layang dan lingkaran dengan KKM = 70 untuk siswa-siswa di wilayan Mataram dan Ampenan dan KKM sebesar 68 di Wilayah Cakranegara. Disisi lain pesan yang disampaikan sama karena nilai rata-rata yang diperoleh siswa setiap kelas untuk masing-masing wilayah tidak berbeda secara signifikan. Dengan demikian penggunan pedoman operasional alat peraga penentuan luas daerah Layang-layang dan luas daerah lingkaran untuk siswa sekolah dasar di Kota Mataram konsisten dan efekitif.
Gender aspects of localization-related and generalized epilepsy
Authors: Asadova U. A. , Magalov Sh. I. 
Published: July 2021

Aim. To study gender and age aspects of epilepsy in patients with localization-related and generalized forms of epilepsy in the village of Mashtaga, Baku city.Material and methods. The gender structure of epilepsy in the village study was conducted simultaneously with a cohort pro- and retrospective research of its epidemiology at the United City Hospital (OGB) No. 7 in the village of Mashtaga and at the Department of Neurology of the Educational and Therapeutic Corps of AMU during the period from 2016 till 2019. Psychoemotional state (Ziqmond scale), severity of seizures (NHS3 scale), quality of life (QOLIE-10 questionnaire) were studied. For statistical processing, Fisher LSD and Pearson’s rank correlation coefficient were used at the level of significant results — p < 0.05.Results and discussion. Among 197 patients with epilepsy, 121 (61.4%) men and 76 (38.6%) women were examined. Most of them were accounted for localization-related epilepsy — 129 people (65.4%). 68 patients (33.5%) suffered from generalized epilepsy. The indigenous (37,505 people) and nonindigenous (8295 people) population were represented mainly by Azerbaijanis. The number of male patients with SPE exceeded the number of females (χ2= 8.515; p = 0.004), (p < 0.05). There were more male patients with HE (41 (60.3%)) than females (27 (39.7%)). The severity of seizures, evaluated with the use of the NHS3 scale, was higher in male patients than in females. The psychoemotional state according to the Ziqmond scale in female patients from non-indigenous inhabitants was lower (9.05 ± 0.30; m = 6, M = 13) than in those of indigenous (8.83 ± 0.21; m = 5, M = 12), (p = 0.046). Assessment of the quality of life of patients with epilepsy according to QOLIE-10, did not reveal any gender diff erence.Conclusions. A gender-specific approach to the condition of patients with epilepsy will contribute to the improvement of both, clinical and psychoemotional parameters, thereby having a positive effect on the quality of life.