bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Relationship Between Sleep and Weight Change Among Women Diagnosed with Breast Cancer Participating in the Women’s Health Initiative
Authors: Donzella Sidney , Lind Kimberly E , Skiba Meghan B , Farland Leslie V , Thomson Cynthia A , Werts Samantha J , Bell Melanie L , LeBlanc Erin , Weitlauf Julie C , Hery Chole M Beverly , Naughton Michelle J , Mortimer Joanne , Crane Tracy E 
Published: October 2021

Abstract
Purpose: Short and long sleep duration and poor sleep quality are risk factors for weight gain and cancer mortality. The purpose of this study is to investigate the relationship between sleep and weight change among postmenopausal breast cancer survivors. Methods: Women participating in the Women’s Health Initiative who were diagnosed with incident breast cancer between year 1 and year 3 were included. Self-reported sleep duration was categorized as ≤5 hours (short), 6 hours, 7-8 hours (optimal), and ≥9 hours (long). Self-reported sleep quality was categorized as poor, average, and above average. Post-diagnosis weight change was the difference of weight closest to, but preceding diagnosis, and year 3 weight. We used linear regression to evaluate sleep duration and sleep quality associations with post-diagnosis weight change adjusted for potential confounders. Results: Among 1,156 participants, 63% were weight stable after diagnosis; average weight gain post cancer diagnosis was 3.2 kg. Six percent of women reported sleeping ≤5 hours, 26% reported 6 hours, 64% reported 7-8 hours, and 4% reported ≥9 hours. There were no differences in adjusted estimates of weight change among participants with short duration (0.37kg; 95%CI -0.88, 1.63), or long duration (-0.56kg; 95% CI -2.03, 0.90) compared to optimal duration, nor was there a difference among poor quality (-0.51kg; 95% CI -1.42, 0.41) compared to above average quality. Conclusion: Among postmenopausal breast cancer survivors, sleep duration and quality were not associated with weight change after breast cancer diagnosis. Future studies should consider capturing change in adiposity and to expand beyond self-reported sleep.
Impact of Historical Land Cover Changes on Land Surface Characteristics Over the Indian Region Using the Land Information System.
Authors: jose vibin , Chandrasekar Anantharaman , Reddy Suraj 
Published: October 2021

Abstract
The present study has employed a regional Land Surface Model (LSM) to investigate the impact of historical land cover changes on land surface characteristics over the Indian subcontinent for the period of 1930-2013. Four simulations that include a control run and three experiment runs are performed with the Noah 3.6 LSM within the Land Information System (LIS). The control run is performed with a MODIS-IGBP land cover map, while the three experimental runs are performed with three different potential land cover maps for the years 1930, 1975, and 2013. The potential land cover maps for the above three simulations are developed by blending the MODIS-IGBP data set with the fractional forest cover data set; the latter data is available for the years 1930, 1975, and 2013. Results indicate that the historical land cover change (1930 to 2013) has reduced the annual mean of latent heat flux and net surface radiation over the Indian domain by -24.74 W/m 2 and -14.18 W/m 2 respectively, while the sensible heat flux and the soil temperature has increased by 4.97 W/m 2 and 2.78 K. The annual mean change in latent heat flux, sensible heat flux, and soil temperature demonstrate that the largest changes occur when the land cover changes from forest to urban land as compared to forest to cropland, forest to grassland and forest to open shrubland. The annual mean change in latent heat flux is moderately large for the land cover change from forest to open shrubland when compared to forest to grassland and forest to cropland. The above is attributed to the effects of evapotranspiration, which has high values for the cropland followed by grassland and open shrubland. Furthermore, the triple collocation method is employed to assess the impact of historical land cover change on soil moisture. Results indicate that the triple collocation method effectively demonstrates the impact of land cover change on soil moisture.
Prospective Evaluation of the Use of Lokivetmab in Dogs With Atopic Dermatitis in Brazil
Authors: Campos Millena Leme , Lucas Ronaldo , Moraes-Filho Jonas , Marco Viviani di , Lopes Jessica Dinelli , Beviani Daniela , Pelegrini Carla , Cunha Vitoria Miranda Carrao 
Published: October 2021

Abstract
Background: Lokivetmab (Cytopoint®, Zoetis) is a caninized anti-IL-31 monoclonal antibody licensed for treating clinical manifestations of canine atopic dermatitis in varying degrees of severity. The objective of this 30-day prospective study was to evaluate the level of improvement in cases of atopic dermatitis after the application of lokivetmab, using the Canine Atopic Dermatitis Extent and Severity Index (CADESI-4) variables, Visual Analogue Scale (VAS) of pruritus, owner assessment of the condition, and incidence of adverse events. A total of 110 animals recruited from two private clinics in the State of São Paulo each received 2 mg of lokivetmab/kg of body weight by subcutaneous injection on day 0. Dogs were observed by owners who provided reports of their observations by telephone or e-mail on days 2 and 14 and were observed by clinicians on day 30. Results: Baseline mean VAS of pruritus was 7.68 (median = 7), decreasing to 3.82 (median = 2) by day 2 (P<0.001). CADESI-4 variables decreased from 36.5 at baseline to 16.3 on day 30 (P<0.001). Reports of treatment responses submitted by owners and evaluation of CADESI-4 variables after treatment were significantly similar (P<0.001). Owners rated the response to treatment as good to excellent for 75% of the dogs. Adverse events, including vomiting, diarrhea, and/or lethargy, were observed in 18 dogs (16.4%). All events were transient, and none required treatment. Conclusions: Based on findings in this study, lokivetmab was determined to provide a rapid and effective response for control of canine atopic dermatitis. Lokivetmab was well tolerated with only mild and transient adverse events observed.
The Impact of Positive Emotional Appeals On The Green Purchase Behavior
Authors: Wang Jianming , He Zhengxia , Wang Jianguo , Bao Jing , Gao Jian 
Published: October 2021

Abstract
Background: The practice of green consumption has become a common initiative of the international community. Existing studies have shown that emotional factors have an important impact on consumer behavior, but few scholars in the field of green consumption behavior have explored the relationship between positive emotions and green purchase behavior in specific dimensions.Methods: This study creatively put forward two dimensions and four kinds of positive emotional appeals which include the cherishing appeal, the yearning appeal, the proud appeal and the admiring appeal. Through the conceptual model analysis based on the data, the effects of different four positive emotional appeals on consumers’ perceived green value, perceived green responsibility, green purchase behaviors were confirmed.Conclusion: The results indicated that the four kinds of positive emotional appeals, perceived green value, perceived green responsibility, green purchase behavior were positively correlated. Perceived green responsibility has significant mediating effect on the relationship between positive emotional appeals and green purchase behaviors. However, surprisingly, perceived green value has no mediation effect in the relationship between positive emotional appeals and green purchase behaviors. Emotional arousal and middle doctrine are not qualified moderators in any situations.
Neutrophils to Lymphocytes Ratio (NLR) Variation in Relationship with Childhood Maltreatment in Patients with Anorexia Nervosa: A Retrospective Cohort Study
Authors: khalil Rami Bou , Risch Nathan , Sleilaty Ghassan , Richa Sami , Seneque Maude , Lefebvre Patrick , Sultan Ariane , Avignon Antoine , Maimoun Laurent , Renard Eric , Courtet Philippe , Guillaume Sebastien 
Published: October 2021

Abstract
Purpose: Anorexia nervosa (AN) is a serious mental illness that is frequently accompanied with a history of childhood maltreatment (CM) which may constitute a specific ecophenotype of the eating disorder necessitating special assessment and management. Chronic stress inflicted by CM in patients with AN may manifest through increased low grade inflammation reflected by an increase in ratios from white blood cells count such as neutrophils to lymphocytes ratio (NLR) platelets to lymphocytes ratio (PLR) and monocytes to lymphocytes ratio (MLR). Methods: N=206 participants were evaluated in an eating disorders daycare unit in Montpellier, France between March 2013 and January 2020. CM was assessed using childhood trauma questionnaire (CTQ). AN clinical severity was assessed using eating disorder examination (EDE-Q). The MINI was used to assess other clinical characteristics. Results: NLR has been found to be higher in patients with AN and a history of CM (p=0.029) as well as in patients with AN and a history of emotional abuse (p=0.021) when compared to patients with AN and without a history of CM. In the multivariate analysis, emotional abuse (β=0.17; p=0.027) contributed significantly to NLR’s variability. Conclusion: NLR is a low grade inflammation marker that is influenced by multiple sociodemographic, clinical and biological factors in patients with AN. It is more directly affected by certain subtypes of CM, especially emotional abuse than by the presence or absence of a history of CM. Future studies may focus on mediators between CM and increased inflammation such as interoceptive awareness, emotional dysregulation, food addiction and stress-sensitization.Level of evidence: Level III: Evidence obtained from well-designed cohort or case-control analytic studies
Deriving Key Architectural Features of FHIR-BlockChain Integration through the Qualitative Content Analysis
Authors: Lee Jaehoon , Park Yu Rang , Beck Sang Sook 
Published: October 2021

Abstract
Background: The blockchain has been highlighted its possibility as a technology to ensure immutability, transparency, and decentralization of data in information systems in various industries. Amongst the possibility of blockchain in the healthcare industry, one of the informatics areas that can leverage the benefits of using blockchain is healthcare information exchange while it is combined with the use of fast healthcare interoperability resources (FHIR).Objective: To investigate the key architectural features of FHIR and blockchain integration that provides the benefits of immutability of transaction data for a decentralized and secured healthcare information exchange framework.Materials and Methods: We conducted an in-depth, individual, semi-structured interview with four domain knowledge experts in the area of FHIR and medical blockchain. Our interview plan were qualified by the COREQ criteria (Consolidated Criteria for Reporting Qualitative Research), which is an analysis method the qualitative content analysis. We conducted the interview based on seven key questions and additional open discussion of technical, business, and legal aspects of the FHIR-blockchain implementations. The results of the interviews were recorded, summarized, and codified in a structured way. Results: The qualitative content analysis revealed the four types of FHIR-blockchain architectures for storing FHIR data and/or transaction and integrating FHIR and blockchain. The four FHIR-blockchain architectures compose of 1) the types of on-chain information from FHIR transactions to be stored inside blocks and 2) the features of the architectures and their possible use case scenarios. In addition to the characterization of the four FHIR-blockchain architectures, we discussed the topics; 1) potential legal issues, 2) justification of using blockchain in healthcare information exchange, and 3) practical implications and guideline of the architectures for implementation.Conclusion: Although FHIR-blockchain integration has been considered as a promising tool for decentralized and secured healthcare information exchange, it should be clarified as to how it aligned with business requirements. A detailed and/or tailored guidelines of implementation in the architectural, functional, and legal perspectives may need to be demonstrated by the benefits of using FHIR-blockchain integration.
Connecting Three Detection Methods To Screen Polyhydroxyalkanoicates Producing Bacteria In General Nature Region
Authors: Chou Hung-Che , Chen Chia-Hsin , Chu Hsiao-Kai , Huang Chun-Mei , Wang Hui-Jun , Tu Wei-Lin , Guo Gia-Luen 
Published: October 2021

Abstract
This study combined the media containing the fluorescent dye Nile red identification method, the genetic detection method of colony polymerase chain reaction (PCR), and gas chromatography (GC) analysis techniques for screening polyhydroxyalkanoates (PHAs) producers isolated from the natural area in Taiwan. Using the three analysis methods can be schemed into different standard operating procedures to complement each other's limitations and shortcomings. We highlight the development of an economic and efficient screening tool that fits each cost process to different environment samples and intensifies the effective discovery of potent PHAs sources. When screening up to 105 samples to be analyzed, the scheme of connecting three detection methods was reduced to 97% of the cost than using the combination of two methods of Nile red + GC or PCR + GC methods. Besides, the unit of time consumed was only 6%. With the number of samples over 108, the researchers need to consider the overall cost, and only the combination of Nile red and PCR methods without GC will lower the cost to 88% and 57% of the time rather than using all three methods, with the true positive rate of 30.7%.
Anthropogenic Land Use/Cover Change Detection And Its Impacts On Hydrological Responses of Genale Catchment, Ethiopia
Authors: Negewo Tufa Feyissa , Sarma Arup Kumar 
Published: October 2021

Abstract
Change in land use land-cover (LULC) is a paramount dynamic present-day challenging landscape process capable of altering the hydrological responses in the catchment. As the land use planners require updated and high-resolution land resources information, understanding land cover change-induced status due to anthropogenic activities is significant. In this study, multitemporal cloud-free satellite imageries for periods (1990, 2002, and 2013) were used to quantify the spatiotemporal dynamics of land-use change detection and examine the effect on hydrological response using Geographical Information System (GIS) and Soil and Water Assessment Tool (SWAT) model in the Genale watershed, Ethiopia. The model performance was evaluated through sensitivity, uncertainty analysis, calibration, and validation process. The analysis of LULC change patterns for the area under study over 24 years showed that most parts of the green forest, barren land, and range shrubs were changed into agriculture, built up, wetlands, and water body with an increase of agriculture by 60%, built up 68%, pasture 37%, range shrubs 9%, and water body 57% over (1990 to 2013), which increased surface runoff, water yield, and sediment yield in the catchment. Significant changes in hydrological elements were observed at the sub-basins scale, mainly associated with the uneven spatial distribution of LULC changes compared to the whole watershed. The impacts of individual LULC change on hydrological response show a good correlation matrix. The regional government needs to modify land development policies and sustainable plans for examining LULC change detection using satellite imagery to avoid illegal land expansion activities.
Prognostic Implications of Impaired Longitudinal Left Ventricular Systolic Function Assessed by Tissue Doppler Imaging Prior to Transcatheter Aortic Valve Implantation for Severe Aortic Stenosis
Authors: gallone guglielmo , Bruno Francesco , Trenkwalder Teresa , D'Ascenzo Fabrizio , Islas Fabian , Leone Pier Pasquale , Nicol Phillip , Pellegrini Costanza , Incaminato Enrico , Jimenez-Quevedo Pilar , Covarrubias Hector Alfonso Alvarez , Bragato Renato , Andreis Alessandro , Salizzoni Stefano , Rinaldi Mauro , Kastrati Adnan , Conrotto Federico , Joner Michael , Stefanini Giulio , Nombela-Franco Luis , Xhepa Erion , Escaned Javier , De Ferrari Gaetano Maria 
Published: October 2021

Abstract
BackgroundChange in longitudinal left ventricular (LV) systolic function serves as an early marker of the deleterious effect of aortic stenosis (AS) and other cardiac comorbidities on cardiac function. We explored the prognostic value of tissue doppler imaging (TDI)-derived longitudinal LV systolic function, defined by the peak systolic average of lateral and septal mitral annular velocities (average S’) among symptomatic patients with severe AS undergoing transcatheter aortic valve implantation (TAVI).Methods and results297 unselected patients with severe AS undergoing TAVI at three european centers with available average S’ at preprocedural echocardiography were retrospectively included. The primary endpoint was the Kaplan Meier estimate of all-cause mortality. After a median 18 months (IQR 12-18) follow-up, 36 (12.1%) patients died. Average S’ was associated with all-cause mortality (per 1 cm/sec decrease: HR 1.29, 95%CI 1.03-1.60, p=0.025), being the cut-off of 6.5 cm/sec the most accurate. Patients with average S’ <6.5 cm/sec (55.2%) presented characteristics of more advanced LV remodeling and functional impairment along with higher burden of cardiac comorbidities, and experienced higher all-cause mortality (17.6% vs. 7.5%, p=0.007), also when adjusted for in-study outcome predictors (adj-HR: 2.69, 95%CI 1.22-5.93, p=0.014). Results were consistent among patients with preserved ejection fraction, normal-flow AS, high-gradient AS and in those without LV hypertrophy.Conclusions Longitudinal LV systolic function assessed by average S’ is independently associated with long-term all-cause mortality among TAVI patients. An average S’ below 6.5 cm/sec best defines clinically meaningful reduced longitudinal systolic function and may aid clinical risk stratification in these patients.
Reconfigurable Hyperbolic Polaritonics with Correlated Oxide Metasurfaces
Authors: Aghamiri Neda Alsadat , Hu Guangwei , Fali Alireza , Zhang Zhen , Li Jiahan , Balendhran Sivacarendran , Walia Sumeet , Sri Sharath , Edgar James , Ramanathan Shriram , Alu Andrea , Abate Yohannes 
Published: October 2021

Abstract
Polaritons enable subwavelength confinement and highly anisotropic flows of light over a wide spectral range, holding the promise for applications in modern nanophotonic and optoelectronic devices. However, to fully realize their practical application potential, facile methods enabling nanoscale active control of polaritons are needed. Here, we introduce a hybrid polaritonic-oxide heterostructure platform consisting of van der Waals crystals, such as hexagonal boron nitride (hBN) or alpha-phase molybdenum trioxide (α-MoO3), transferred on nanoscale oxygen vacancy patterns on the surface of prototypical correlated perovskite oxide SmNiO3 (SNO). Using a combination of scanning probe microscopy and infrared nanoimaging techniques, we demonstrate nanoscale real-time reconfigurability of complex hyperbolic phonon polaritons patterned at the nanoscale with unmatched resolution. Hydrogenation and temperature modulation allow spatially localized conductivity modulation of SNO nanoscale patterns, enabling robust real-time modulation and nanoscale reconfiguration of hyperbolic polaritons. Our work paves the way towards nanoscale programmable metasurface engineering as a new paradigm for reconfigurable nanophotonic applications facilitated by a hybrid material platform exploiting extreme light-matter interactions in polaritonic systems.
Nutritional status and related factors on academic achievement of adolescents in high schools in the Hlaing Tharyar township, Yangon, Myanmar
Authors: Soe Yee Mon , Maneekan Pannamas , Soonthronworasri Ngamphol , Prangthip Pattaneeya 
Published: October 2021

Abstract
BACKGROUND/OBJECTIVES:
Chronic malnutrition in adolescents may result in significant academic difficulties at school. This study aimed to determine the impact of nutritional status and related factors on the academic achievement of adolescents in secondary/high schools in Myanmar.
SUBJECTS/METHODS:
A cross-sectional survey was performed in two high schools in Hlaing Tharyar District, Yangon using a self-administered questionnaire on food intake and other factors potentially affecting nutritional status. Grade-point averages (GPA) in the previous academic year were recorded to identify any association between nutritional status and academic achievement.
RESULTS
We enrolled 301 students aged 13–17 years (mean ± SD, 14.43 ± 0.95). Over half of the respondents were female (65.1%). Most of the respondents showed normal body mass index values, followed by underweight, overweight and obesity. Regarding academic achievement, a GPA of A, B, C and D was seen in 41.5%, 36.2%, 15.3%, and 7.0% of the respondents, respectively. Nutritional status was significantly associated with academic achievement. Underweight students had a 1.96 times higher likelihood of achieving mediocre grades (C, D) compared to normal-weight students (OR = 1.960, 95% CI: 1.063–3.614). Among other factors examined, only the number of meals per day was associated with nutritional status. Apart from the number of meals per day, the duration of walk to school, the duration of watching or playing games, and the parents’ socioeconomic status were associated with academic achievement.
CONCLUSIONS
There is a relationship between nutritional status and related factors on levels of academic achievement of adolescent students in the Yangon metropolitan area.
An exploration of the statutory Healthy Start vitamin supplementation scheme in North West England
Authors: Moonan May , Maudsley Gillian , Hanratty Barbara , Whitehead Margaret 
Published: October 2021

Abstract
Background
Government nutritional welfare support from the English ‘Healthy Start’ scheme is targeted at low income pregnant women and preschool children, but take-up of its free food vouchers is much better than its free vitamin vouchers. While universal implementation probably requires a more extensive scheme to be cost-effective, the everyday experience of different ways of receiving or facilitating Healthy Start, especially via children’s centres, also requires further evidence. This study therefore aimed to explore (in the context of low take-up levels) perceptions of mothers, health professionals, and commissioners about Healthy Start vitamin and food voucher take-up and compare experiences in a targeted and a universal implementation-area for those vitamins.
Methods
Informed by quantitative analysis of take-up data, qualitative analysis focused on 42 semi-structured interviews with potentially eligible mothers and healthcare staff (and commissioners), purposively sampled via children’s centres in a similarly deprived universal and a targeted implementation-area of North West England.
Results
While good food voucher take-up appeared to relate to clear presentation, messaging, practicality, and monetary (albeit low) value, poor vitamin take-up appeared to relate to overcomplicated procedures and overreliance on underfunded centres, organizational goodwill, and families’ resilience.
Conclusion
Higher ‘universal’ vitamin take-up may well have reflected fewer barriers when it became everyone’s business to be vitamin-aware. Substantive Healthy Start reform in England (not just cosmetic tinkering) is long overdue. Our study highlights that ‘policy, politics, and problem’ should be aligned to reach considerable unmet need. 237 words