bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Immediate Effects Oon Usage of Dual Polymer Artificial Tears on Changes in Tear Film Characteristics
Authors: Che Arif Fatin Amalina , Hilmi Mohd Radzi , Mohd Kamal Khairidzan , Ithnin Mohd Hafidz 
Published: January 2021

Introduction: This study aimed to evaluate the short-term efficacy of artificial tears (AT) instillation on tear film quality and quantity utilising two dual polymer artificial tears; Systane Hydration preservative (SH) and non-preservative (SHUD) in 60 minutes observation period compared to normal saline. Materials and methods: One hundred eyes of 50 participants involved in this prospective, double-masked randomised study. Viscosity and pH of both AT were evaluated using Rheometer and digital pH-meter respectively prior to tear film characteristics assessment. Tear break-up time (TBUT) and tear meniscus height (TMH) were measured at baseline, 5, 15 and 60 minutes after instillation. Tear ferning pattern (TFP) were compared between baseline and 60 minutes after instillation. One-way analysis of variance (ANOVA) was used to evaluate the effects of both AT instillation. Independent T-test was employed to compare between the two groups (SH vs SHUD) for each specific time-interval. P-value of 0.05 was set as the level of significance. Results: The viscosity of SH and SHUD was 0.0267Pa.s and 0.03273Pa.s respectively with pH of 7.85 for SH and 7.74 for SHUD. Both AT showed significant increment in TBUT between baseline and 15 minutes (SH: 5.82 ± 1.063, p = 0.01; SHUD: 6.02 ± 0.979, p<0.001), and 60 minutes (SH: 6.22 ± 0.616, p<0.001; SHUD: 6.34 ± 0.658, p<0.001). SHUD demonstrated significant increment in TMH at every measurement taken (0.1996 ± 0.02449, p<0.001 at 5min, 0.2038 ± 0.02276, p<0.001 at 15min and 0.2068 ± 0.02094, p<0.001 at 60min). Likewise, in SH group, significant increment in TMH at 15 minutes (0.1994 ± 0.02325, p < 0.001) and 60 minutes (0.2012±0.02379, p<0.001) were noted. With regards to TFP, both groups revealed improvement in TF grading (both, p<0.001) at 60 minutes. No significant improvement was noted in control group. Conclusion: Both SH and SHUD improved tear film characteristics at 60 minutes following instillation. However, SHUD is more effective as faster improvements were noted in all intended parameters.
Can Doctors Be App Developers? Our Experience As Medical Educators
Authors: Liang Goh Kian , Noor Rahin Mohd Shahidan , Abdul Razak Ardilla Hanim , Awang Mohd Shukrimi 
Published: January 2021

Introduction: Smartphone and mobile apps have become an indispensable companion in our modern-day living and working environment. In the medical field, web browsers and medical apps have transformed the medical practice as the most current knowledge, best practices, medical references, and calculators are available instantaneously at our fingertips. However, these functionality and usage are limited by the creativity and imagination of the app developers. To overcome these limitations, doctors should think out-of-the-box and educate themselves to be appdevelopers to create functional and useful apps in their field. Our aim was to create medical apps from ground-up independently without formal software development training. Material and method: Hybrid app technology is a popular method for creating apps for newbies due to the familiarity with web browsers. We explore the IonicÂ© Framework which is a free and open-source front-end with good resources and documentation. This programming technology assumes that everyone has experience with web browsers and the modern browsers essentially run on three technology stacks which are Hypertext Markup Language (HTML), JavaScript and Cascading Style Sheets (CSS). The HTML is a standard markup language for web browser while JavaScript is a scripting language for running commands and functions. The CSS is used for describing how HTML elements should be displayed. Results: We successfully published three apps on the Apple AppStore and Google Play, namely, OrthoBoard©, OpList and OOLH. Based on our experience of designing, coding, testing and deploying the apps, it is not impossible for medical doctors to achieve this goal and utilizing the app-development skills as an armamentarium for teaching, learning, and medical practice tools. Conclusions: App development is an essential skill especially for medical educators to leverage the technological advancement in their teaching and learning as well as medical practice in tandem with our nations’ aspiration towards Education 4.0.
A Comparative Study of the Personality Formulates of Ghazali and Freud
Authors: Hanna-e-Kalbi  , Dr. Tahira Basharat  
Published: January 2021

This research is a comparative study of the types of nafs and the types of personality described by Ghazali and Freud, respectively. Types of personality described by Ghazali are al-nafs al-ammara, al-nafs al-lawwama and al-nafs al-mutma'inna. The types of personality according to Freud are id, ego and super-ego. Other faculties that help in training or shaping the types of nafs are rooh (soul), qalb (heart), and aql (mind). They also play a vital role in the functioning of id, ego and super-ego.
This article defines the above mentioned types of personality presented by both Ghazali and Freud. It also discusses their functions encompassing their differences and similarities and strives to find out if they complement each other. It was found that there is much similarity in both types of personality formulates. Id and nafs ammarah are the same, while nafs lawwama was found to be comprising both ego and super-ego. However, the concept of nafs mutma’innah is found only in Islamic theology.
Thematic and comparative study methods of qualitative research were used in this research. This is a literature based study. Ghazali’s study is based on the Qur’an and Sunnah. Hence, Ihya’ ‘Uloom-id-Deen and The Ego and The ID remain the major sources of this study.
Leches a base de plantas: Almendras
Authors: Torna Elena , Rivero-Mendoza Daniela , Dahl Wendy J. 
Published: January 2021

La leche de almendras, una alternativa a la leche de origen vegetal, se produce a partir de almendras y agua. La leche de almendras tiene su origen en la región mediterránea y se consume desde hace muchos años. En los Estados Unidos, hay varias marcas comercializadas de leche de almendras. Esta publicación describe el perfil de nutrientes y los posibles beneficios y riesgos para la salud de la leche de almendras.
This new 3-page publication of the UF/IFAS Food Science and Human Nutrition Department is the Spanish version of FSHN20-48/FS410. Written by Elena Torna, Daniela Rivero Mendoza, and Wendy J. Dahl.https://edis.ifas.ufl.edu/fs423
PERKEMBANGAN NILAI AGAMA DAN MORAL (STTPA TERCAPAI)
Authors: Nurjanah Siti 
Published: January 2021

Penelitian ini bertujuan untuk mengetahui pengembangan nilai agama dan moral anak usia dini dalam mencapai STPPA dan untuk mengetahui apasaja yang dapat mempengaruhi perkembangan nilai agama dan moral anak usia dini dalam mencapai STPPA. Penelitian ini adalah penelitian kualitatif dengan metode deskriptif analitik. Teknik pengumpulan data menggunakan wawancara kemudian subjek dalam penelitian ini adalah siswi Taman Kanak-Kanak ‘Aisyiyah Bustanul Athfal Sapen Yogyakarta dengan nama Siti Aisyah Khaira. Hasil dari penelitian ini menunjukan bahwa perkembangan nilai agama dan moral subjek sudah tercapai sesuai dengan standar tingkat pencapaian perkembangan anak.
La gestión de la innovación en las agencias de viajes cubanas
Authors: Olivera Elosegui Rebeca , Rodríguez González Maité 
Published: January 2021

La innovación se ha convertido en uno de los instrumentos fundamentales dentro de las empresas que quieren seguir siendo competitivas en un entorno cada vez más complejo y cambiante. No obstante, muchas entidades del sector turístico cubano, específicamente las agencias de viajes, presentan una insuficiente Gestión de la Innovación y se desconoce cuál es su situación actual. Por lo que se plantea como objetivo de la presente investigación: Valorar la gestión de la innovación en las agencias de viaje generalistas, pertenecientes a (OSDE) Viajes Cuba. Para ello se determinó aplicar en tres agencias de viajes, uno de estos modelos de diagnóstico y mejora de la gestión de la innovación: Guía para la Autoevaluación de la Gestión de la Innovación) Empresarial elaborada por Centro Andaluz para la Excelencia en la Gestión, (2009), El Modelo de las 7 Dimensiones (7 D´s) de Arzola & Mejías, (2007), y la fusión del modelo del Centro de Innovación y Desarrollo Empresarial de la Generalitat de Catalunya (CIDEM) desarrollado en el año 2002 y el procedimiento para la evaluación de la Gestión de la Innovación propuesto por la misma institución en el 2009. Las etapas correspondientes al diagnóstico dentro de estas metodologías incluyeron la aplicación de cuestionarios, entrevistas a directivos, entrevista a profundidad a especialistas de I+D+i y análisis documental. El diagnóstico y la aplicación de la Matriz de Vester, el árbol de problemas y el árbol de objetivos, posibilitaron la identificación de las brechas existentes entre el estado ideal y actual, permitiendo estructurar el marco lógico para la mejora, así como establecer un conjunto de indicadores para la planificación y el control en estas instituciones turísticas.
Aggregate Stability in Soils of Twelve Argo-ecological Zones of Bangladesh Based on Organic Carbon and Basic Cations
Authors: Arofi S , Rahman MM , Shiragi HK , Alam MA , Islam MM , Biswas JC 
Published: January 2021

Soil aggregate is one of the vital indicators of soil health that depends on organic carbon (OC), texture and basic cations. A total of 206 soil samples were collected from 12 agro-ecological zones (AEZs) of Bangladesh to study the effects of organic carbon (OC), basic cations (Ca, Mg, K and Na) and different sized soil particles on soil aggregate stability. Soil samples were analyzed for bulk density, pH, OC, texture, basic cations and water stable soil aggregates (WSA) following standard protocols. Data revealed that OC positively increased WSA, while monovalent basic cations Na+ and K+ showed negative effects. Water stable soil aggregates and C stock of 0.25 mm sized soil fraction were found higher than that of larger sized soil fractions of 0.5, 1.0 and 2.0 mm. The roles of divalent basic cations Ca2+ and Mg2+ on WSA were found to be indistinct and need to be studied further.
Ann. Bangladesh Agric. (2019) 23(2) : 27-36
Influence of Harvesting Date on Chemical Maturity for Processing Quality of Potatoes
Authors: Sharkar M , Ahmed JU , Hoque MA , Mohi-Ud-Din M 
Published: January 2021

The present study was conducted to find out a suitable harvesting date of processing potato varieties (Asterix, Courage and Lady Rosetta) from three different harvest dates [80, 90, and 100 days after planting (DAP) harvest] by chemical maturity monitoring. Eighty DAP harvest resulted the lowest mean total soluble sugar (TSS) (3.77 mg/g FW), reducing sugar (RS) (1.57 mg/g FW), sucrose (2.40 mg g-1 FW), fructose (0.77 mg/g FW) and polyphenol (238.94 μg/g FW) contents in all the varieties and at the same DAP harvest, dry matter (DM) content (21.71%) and chip color index (CCI) (0.67) remained at the lowest. Tubers harvested at 80 DAP produced good quality and acceptable colored processed products as it meets up the required processing quality, but lesser DM content might increase the cost of the product. Optimum DM content (24.07%) with moderate level of different sugar contents and acceptable CCI (1.13 to 1.85, <2.00) was found at 90 DAP harvest. Therefore, 90 DAP harvest could be considered as suitable harvesting date for processing by compromising some quality parameters (TSS, RS, sucrose, fructose and polyphenol contents). Among the varieties, Lady Rosetta and Courage were preferable for producing quality potato products. Highly significant and positive correlation existed between CCI and different chemical parameters. A strong correlation coefficient (r = 0.822**) and good fit (R2 = 0.6755) of the regression equation (CCI = 0.9341RS – 0.4969) between CCI and RS indicated that RS content played the vital role in the browning of the processed potato products.
Ann. Bangladesh Agric. (2019) 23(2) : 89-103
Avaliação microbiológica dos leitos cirúrgicos de um hospital público oncológico da região norte do Brasil
Authors: Vaz Davis Wilker Nascimento , Sousa Yasmin Martins de , Cavalcante Rosiane Luz , Almeida Maria das Graças Carvalho , Lima Karla Valéria Batista , Silva Júnior Ademir Ferreira da 
Published: January 2021

Objetivo: avaliar as condições microbiológicas dos leitos de um Centro Cirúrgico de um Hospital público de ensino do Município de Belém, Pará. Métodos: Executou-se a coleta de amostras dos leitos cirúrgicos após a sua desocupação, por meio de rolamento de swab umedecido em solução salina esterilizada, antes e após a desinfecção dos leitos. As amostras foram processadas no Setor de Bacteriologia do Laboratório de Análises Clinica do CESUPA- LAC/ CESUPA. O teste de sensibilidade aos antimicrobianos foi realizado pelo método de disco difusão por meio da técnica de Kirb Bauer e o resultado expressou-se como sensível, moderadamente resistente (intermediário) e resistente. Resultados: Nas amostras coletadas dos leitos cirúrgicos, foram isoladas diferentes espécies do gênero Staphylococcus: S. aureus, S. epidermidis e S. saprophyticus, as quais apresentaram mais resistência à Penicilina, Azitromicina e Vancomicina, respectivamente. Após a desinfecção, observou-se uma redução das espécies S. aureus e S. epidermidis e um aumento da S. saprophyticus. Com relação às Gram negativas, de todas as amostras coletadas, só em duas elas positivaram, sendo ambas na coleta antes da desinfecção dos leitos. Na coleta após a desinfecção, as amostras Gram negativas negativaram. A desinfecção foi mais efetiva para as bactérias Gram negativas do que Gram positivas. Conclusão: Portanto, a análise microbiológica realizada nos leitos cirúrgicos, antes e após a desinfecção, demonstrou que eles possuíam uma carga microbiana elevada, constituindo assim, uma possível fonte de contaminação ambiental capaz de desencadear um processo infeccioso.
Proyecto del puente extradosado sobre el Río Barrow
Authors: Astiz Suárez Miguel Ángel , Blanco Martín Lucía , Sánchez Sánchez Marcos , Ayuso Calle Guillermo , Gil Ginés Miguel Ángel , González Aguilar Raúl 
Published: January 2021

El Puente sobre el río Barrow en New Ross (Irlanda) tiene una longitud total de 887,0 m e incluye cuatro vanos extradosados y cinco vanos de aproximación hacia sus extremos Este y Oeste. La distribución de luces de Oeste a Este es 36 + 45+ 95 + 230 + 230 + 95 + 70 + 50 + 36 m. Los vanos más largos están parcialmente soportados mediante tirantes paralelos que se anclan en tres pilonos situados en la mediana (Figura 1).
Las tres torres de atirantamiento son de sección variable, las dos laterales de 16.20 m de altura sobre el tablero y la central de 27 m de altura sobre tablero y 60 m de altura sobre la cimentación. Los cables de atirantamiento son paralelos y pasan a través de las torres mediante sillas. Están organizados en un solo plano central por lo que necesariamente son de gran sección estando constituidos por hasta 125 cordones.
El tablero está formado por un cajón de hormigón pretensado de almas verticales y canto variable entre 8.5 y 3.5 m. Su anchura tipo es de 21.9 m que se alcanzan con un cajón de 8 m y vuelos de 7 m de anchura. Los vuelos están soportados por puntales que se materializan mediante losas nervadas prefabricadas haciendo que el intradós del puente esté formado por superficies continuas y creando en el tablero dos espacios interiores practicables de sección triangular. El tablero está pretensado longitudinalmente para colaborar en la flexión longitudinal y también transversalmente para colaborar en la resistencia frente a las fuerzas de anclaje de los tirantes.
El final de la construcción de este puente está previsto en los últimos meses de 2019 y será la mayor luz construida en el mundo mediante tableros extradosados de hormigón.
Efectos del viento en el proyecto del puente atirantado entre las islas de Cebú y Mactán (Filipinas)
Authors: Manterola Armisén Javier , Muñoz-Rojas Javier , Astiz Miguel Ángel , Manouchehri Pedram , Orgueta-Gutiérrez Mikel 
Published: January 2021

El puente atirantado de Cebú-Cordova tiene 651,50 m de largo con una distribución de vanos de 5.75-60-65-390-65-60-5.75 y cuenta con un tablero de hormigón pretensado con sección cajón atirantado de dos torres verticales. La acción del viento es particularmente importante al estar en una zona de frecuente paso de tifones tropicales. La velocidad de viento de diseño era de 250 km/h. Para caracterizar el comportamiento de la estructura tanto aerodinámicamente como aeroelásticamente se llevaron a cabo diversos estudios:

Ensayo en túnel de viento para caracterizar aerodinámicamente el tablero y la torres y aeroelasticamente el tablero.
Cálculos con dinámica de fluidos computacional (CFD) para evaluar los coeficientes aerodinámicos de torre y tablero
Comprobaciones aeroelásticas de acuerdo al Eurocódigo y por medio de un modelo con dos grados de libertad para evaluar la sensibilidad de la torre frente al galope. omprobaciones análíticas de su estabilidad aeroelástica.

Todas las comprobaciones aeroelásticas confirmaron el adecuado comportamiento de la estructura.
Effects of Rhythm and Rate-Controlling Drugs in Patients With Permanent His-Bundle Pacing
Authors: Su Lan , Xia Xue , Liang Dongjie , Wu Shengjie , Xu Lei , Xu Tiancheng , Wang Songjie , Chen Xiao , Huang Weijian 
Published: January 2021

Introduction: Antiarrhythmic drug therapy can affect pacemaker parameters in both the atrial and ventricular myocardium. It is not known whether antiarrhythmic drugs impact His bundle pacing/sensing parameters and His to ventricle (H-V) intervals following permanent His bundle pacing (HBP). The aims of the study were to prospectively determine the influence of rhythm and rate-controlling drugs on pacing parameters and H-V conduction after His bundle lead implantation and to assess the impact of rhythm and rate-controlling drugs on the safety of HBP.Materials and Methods: Patients (N = 140) with QRS duration &lt; 120 ms who met permanent pacing indications were prospectively enrolled. Propafenone, lidocaine, and adenosine were injected intravenously after implantation of 3,830 lead during the procedure. Metoprolol succinate, amiodarone, and digoxin were taken orally for 1 month. Pacing parameters before and after drug intervention was measured, including His capture threshold, sensing and impedance, H-V interval, and conduction.Results: There were no statistically significant differences in His bundle pacing thresholds, impedance, and sensing after drug intervention at implantation or during a 2-month follow-up (P &gt; 0.05). The HV interval was not affected except in the large-dose propafenone group where HV interval prolonged (P = 0.001). All patients maintained 1:1 H-V conduction following drug administration.Conclusion: There was no adverse impact on the HBP parameters or H-V conduction after the administration of commonly used dosage of rhythm and rate-controlling drugs. The drugs were safe in patients with permanent His bundle pacing.
Integration of Transcriptome Resequencing and Quantitative Proteomics Analyses of Collagenase VII-Induced Intracerebral Hemorrhage in Mice
Authors: Cao Fang , Guo Yu , Zhang Qiang , Fan Yinchun , Liu Qian , Song Jiancheng , Zhong Hua , Yao Shengtao 
Published: January 2021

ObjectiveIntracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and morbidity rates. Our aim was to comprehensively analyze transcriptome and proteome in an experimental ICH model.MethodsAll mice were divided into ICH model (n = 3) and sham groups (n = 3). ICH was induced by collagenase VII. The ipsilateral hemisphere was used for whole transcriptome and proteomics resequencing. After preprocessing, differentially expressed lncRNAs (DElncRNAs), mRNAs (DEmRNAs), miRNAs (DEmiRNAs), and DEproteins between ICH and sham groups were identified. Functional enrichment analysis was performed using the clusterProfiler package, followed by protein–protein interaction (PPI) analysis. After that, the Pearson correlation coefficient between DEmRNAs and DElncRNAs or between DEmRNAs and DEproteins was calculated. DElncRNAs with similar functions were analyzed by the GOSemSim package. After prediction of DEmiRNA–DEmRNA and DElncRNA–DEmiRNA relationships, a competing endogenous RNA (ceRNA) network was constructed. Several DEmRNAs and DElncRNAs were validated in ipsilateral hemisphere tissues of the ICH model and control groups using RT-qPCR and western blot.ResultsBetween the ICH and sham groups, 31 DElncRNAs, 367 DEmRNAs, 35 DEmiRNAs, and 96 DEproteins were identified. DEmRNAs were mainly enriched in inflammation, such as cytokine–cytokine receptor interaction, IL-17, and TNF signaling pathways. A PPI network of DEmRNAs was constructed and hub genes were identified, such as IL6 (degree = 59), TNF (degree = 44), and CXCR2 (degree = 39). 24 DElncRNAs with similar functions were identified, including 15 up- and 9 down-regulated lncRNAs. After integration of DEmiRNA–DEmRNA and DElncRNA–DEmiRNA relationships, we constructed a ceRNA network, composed of 71 DEmRNAs, 17 DEmiRNAs, and 12 DElncRNAs. RT-qPCR and western blot results confirmed that C3, Fga, and Slc4a1 proteins were more lowly expressed and Penk was more highly expressed in ICH than control groups, which could become potential markers for ICH.ConclusionOur findings identified ICH-related DE-RNAs and proteins and potential molecular mechanisms of ICH by transcriptome resequencing and quantitative proteomic analyses.
A Metabolism-Related Radiomics Signature for Predicting the Prognosis of Colorectal Cancer
Authors: Cai Du , Duan Xin , Wang Wei , Huang Ze-Ping , Zhu Qiqi , Zhong Min-Er , Lv Min-Yi , Li Cheng-Hang , Kou Wei-Bin , Wu Xiao-Jian , Gao Feng 
Published: January 2021

Background: Radiomics refers to the extraction of a large amount of image information from medical images, which can provide decision support for clinicians. In this study, we developed and validated a radiomics-based nomogram to predict the prognosis of colorectal cancer (CRC).Methods: A total of 381 patients with colorectal cancer (primary cohort: n = 242; validation cohort: n = 139) were enrolled and radiomic features were extracted from the vein phase of preoperative computed tomography (CT). The radiomics score was generated by using the least absolute shrinkage and selection operator algorithm (LASSO). A nomogram was constructed by combining the radiomics score with clinicopathological risk factors for predicting the prognosis of CRC patients. The performance of the nomogram was evaluated by the calibration curve, receiver operating characteristic (ROC) curve and C-index statistics. Functional analysis and correlation analysis were used to explore the underlying association between radiomic feature and the gene-expression patterns.Results: Five radiomic features were selected to calculate the radiomics score by using the LASSO regression model. The Kaplan-Meier analysis showed that radiomics score was significantly associated with disease-free survival (DFS) [primary cohort: hazard ratio (HR): 5.65, 95% CI: 2.26–14.13, P &lt; 0.001; validation cohort: HR: 8.49, 95% CI: 2.05–35.17, P &lt; 0.001]. Multivariable analysis confirmed the independent prognostic value of radiomics score (primary cohort: HR: 5.35, 95% CI: 2.14–13.39, P &lt; 0.001; validation cohort: HR: 5.19, 95% CI: 1.22–22.00, P = 0.026). We incorporated radiomics signature with the TNM stage to build a nomogram, which performed better than TNM stage alone. The C-index of the nomogram achieved 0.74 (0.69–0.80) in the primary cohort and 0.82 (0.77–0.87) in the validation cohort. Functional analysis and correlation analysis found that the radiomic signatures were mainly associated with metabolism related pathways.Conclusions: The radiomics score derived from the preoperative CT image was an independent prognostic factor and could be a complement to the current staging strategies of colorectal cancer.