bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding the Generation and Regulation of IL-4 Producing T Helper 2 Cells
Authors:   , Mearns Helen 
Published: November 2021

<p>A keenly sought therapeutic approach for the treatment of allergic disease is the identification and neutralization of the cytokine that regulates the differentiation of Th2 cells. Th2 cells are CD4 T cells differentiated to secrete IL-4. These cells are exciting new targets for asthma therapies due to the key role they play in allergic airway diseases. Recently the cytokine IL-25 has been shown to enhance Th2 cell activity and play important roles in mediating allergic inflammatory responses. To investigate this further we crossed IL-25 deficient mice with GFP-IL-4 reporter mice and developed an assay of in vitro and in vivo IL-4 independent Th2 differentiation. These assays were used to determine whether IL-25 was critical for the formation of Th2 cells. We found there was no physiological role for IL-25 in either the differentiation of Th2 cells or their development to effector or memory Th2 subsets. In the strong Th2 setting of a helminth infection the absence of IL-25 resulted in no defects in the effector type 2 responses associated with T helper type 2 immunity including, mucous hyperplasia, class switching to IgE and protection against challenge infections. Importantly this data challenges the newly found and growing status of the cytokine IL-25 and its proposed role in promoting Th2 responses. The second part of this thesis investigated whether the genomic organisation, which reflects commitment to Th2 cytokine expression, could provide a clearer definition of a functional in vivo Th2 cell. Two distinct IL-4 reporter mice were crossed and Th2 in vivo assays were developed that allowed tracking of the individual alleles of IL-4 in a variety of tissue types and Th2 subsets. Interestingly in vivo expression of IL-4 is mostly monoallelic yet there is a small highly activated population of biallelic IL-4 expressing Th2 cells. Physiologically each allele of IL-4 was required for a functional Th2 response with total serum IgE titres up to 4 fold lower in IL-4+/- heterozygous compared to the IL-4+/+ sufficient animals and a significant loss in protective immunity against challenge infections with helminths occurred in the IL-4+/- heterozygous animals. The similarity in deficiencies in Th2 immunity in the IL-4+/- heterozygous and IL-4-/- deficient compared to the IL-4+/+ sufficient animals lead to the proposal that the generation of biallelic Th2 cells may be required for specialised cell-to-cell mediated delivery of tailored activation signals and higher quantities of IL-4 required to mediate fully developed Th2 immune responses.</p>
Community Governance and Civil Society: An Examination of the Purpose, Intent and Structure of Residents' Groups in New Zealand
Authors:   , Coburn Jarrod 
Published: November 2021

<p>Residents’ groups have been in existence in New Zealand for almost 150 years yet very little is known about them. The collection of residents’, ratepayers’ and progressive associations, community councils, neighbourhood committees and the like make up a part of the community governance sector that numbers over a thousand-strong. These groups are featured prominently in our news media, are active in local government affairs and expend many thousands of volunteer hours every year in their work in communities… but what exactly is that work? From the literature we see these groups can be a source of local community knowledge (Kass et al., 2009), a platform for political activity (Deegan, 2002), critical of government (Fullerton, 2005) or help maintain government transparency and accountability (Mcclymont and O'Hare, 2008). They are sometimes part of the establishment too (Wai, 2008) and are often heard promoting the interests of local people (Slater, 2004). Residents’ groups can be set up to represent the interests of a specific demographic group (Seng, 2007) or focus on protecting or promoting a sense of place (Kushner and Siegel, 2003) or physical environment (Savova, 2009). Some groups undertake charitable activities (Turkstra, 2008) or even act in a negative manner that can impact on the community (Horton, 1996). This research examines 582 New Zealand organisations to derive a set of purposes that residents’ groups perform and ascertains how their purposes differ between geo-social and political locality and over three distinct eras of community development. The thesis also examines the relationship between residents’ groups and councillors, council officers, district health board members and civil defence and seeks to uncover if the level of engagement (if any) has an affect on their overall raison d’etre. The research concludes with a typology of New Zealand residents’ groups along with the key purposes of each type.</p>
Faces and Orientational Metaphors: The Effects of Valenced Faces and Facial Manipulations on Neutral Targets
Authors:   , Moshenrose Sara C. 
Published: November 2021

<p>Previous research has shown that there may be an association between affect (negative vs. positive) and vertical position (up vs. down) of stimuli. The following research aimed to investigate whether individuals show spatial biases, either up or down, when asked to respond to neutral targets after seeing valenced faces. The research also aimed to investigate what impact manipulating automatic facial mimicry responses would have on response times. The research was conducted over three experiments. In Experiment 1, participants responded to neutral targets in either high or low vertical positions on a computer screen that were preceded by happy and sad schematic faces. There were two facial manipulation conditions. One group held a straw between their lips to inhibit smiling and another group held a straw between their teeth to facilitate smiling. A third group performed the response task without a straw (control condition). The procedure of Experiment 2 was identical to Experiment 1 except the happy and sad schematic faces had additional internal facial features (noses, eyebrows) that varied across trials. For both Experiment 1 and 2, targets preceded by a happy face were responded to significantly faster. In Experiment 3, the procedure was identical to Experiments 1 and 2, except photographic images of happy, neutral, and sad expressions were used. Participants were significantly faster to respond to targets in the high vertical position. Participants were also faster to respond to targets in the control (no straw) condition than the other two straw conditions. In the inhibition smiling condition, participants were faster to respond to targets in the high vertical position than low vertical position after seeing a happy or neutral face. These findings indicate that there may be an association between valenced faces and vertical selective attention that is consistent with orientational metaphors (positive = up), but further research is needed to clarify this.</p>
Developing Identities: The Relational Identities of New Zealand NGOs
Authors:   , Johnston Andrew 
Published: November 2021

<p>Non-Governmental Organisations (NGOs) are significant institutions within development. Ideally, they represent the voice and aspirations of grassroots communities and they are born of a movement of local communities in the North and South. NGOs, however, are experiencing a crisis of identity. Changing geopolitical paradigms, increasingly critical analysis from the development academy and, in New Zealand especially, significant changes in the funding environment have caused substantial challenges to NGO identity, purpose and legitimacy. This research qualitatively assesses the identity of Northern NGOs (NNGOs) in New Zealand. It explores the elusive identity of these organisations through the focal point of their partnerships. Using narrative analysis in semi-structured interviews with development practitioners from varied organisations, this thesis elucidates the challenges and aspirations of NNGO identity. This thesis analyses these identities through three themes: in the manner in which they communicate their identity to their partners and supporters; in their understanding and enactment of the inherent power imbalances of the North-South dichotomy; and in the forming of relationships in the South that inform their primary functional identity. In response to the changing environment within which they work, NNGO identities are increasingly fragmented, their roles as fundraisers, programme workers and advocates for justice often conflict and inform an identity that is multiple, fluid and complex. Contemporary NNGOs must find legitimacy in their connection to the grassroots in the North and the South, in advocacy, in programming, in fundraising and in fulfilling their in role of translators and mediators of development. The changes to the New Zealand government‘s support of NNGOs have brought a significant challenge to these roles, and the NNGO response to these challenges will be definitive in the years to come. Most importantly, NNGOs are reclaiming their role as the representatives of a transnational movement of people working together to bring equity and justice, and to facilitate development that local communities can understand and control.</p>
An Examination of the Impact of a Training Programme Based on Sport Psychology for a Cohort of Contemporary Singing Students
Authors:   , Cairns-James Sandy 
Published: November 2021

<p>Sport psychology is well recognised and accepted as an important aspect of sports training, especially for elite athletes. Sport psychology focuses on teaching skills and methods such as goal setting and mental preparation for athletes so that they can develop their psychological abilities to the same high level as their physical abilities. Few researchers have linked sports and singing training, but it appears that many of the techniques used in sport psychology could be of value in developing singers’ practice and performance skills. This study examined the overall impact of introducing sport psychology based training into the curriculum of a cohort of tertiary level contemporary singing students, using a qualitative case study approach. Five categories from sport psychology methods were identified for the purpose of this research: deliberate practice, self-efficacy, motivation, goal setting and peak performance were introduced into the teaching of the singing programme. Analysis of the impact revealed that sport psychology methods were not easily transferable into this vocal curriculum. The outcomes showed that the participants’ level of development in terms of learning skills was at a lower level than the demands of sport psychology</p>
Feminist Critiques of the Multiculturalism and the Case of South Korea: Marriage Migrants, Patriarchy, and Nation-Building
Authors:   , Ku Sun A 
Published: November 2021

<p>Feminist critiques of multiculturalism have largely focused on group rights by looking at multicultural societies that are based on pluralism. However, in some countries of new immigration, such as South Korea, multiculturalism does not necessarily have a pluralist form, but instead pursues assimilation. Thus South Korea provides an opportunity to explore gendered aspects of multiculturalism in a different context from that upon which the existing feminist critiques are largely based. What are the gendered aspects of South Korean multiculturalism? In this study I address this question by looking at policies designed particularly for female marriage migrants. I argue that the aim of these policies is to make such migrants contribute to South Korea’s multicultural nation-building process through their reproductive, care-giving, and symbolic functions in the idealized Korean family and that patriarchy is reinforced in the implementation of these policies. This reinforcement of patriarchy has resulted in a perpetuation of gender inequality. Looking at the ways in which the South Korean government uses female marriage migrants as instruments in its nation-building process expands the current scope of feminist critiques of multiculturalism.</p>
Mathematical Modelling of Acute Rheumatic Fever
Authors:   , Welsh Melissa 
Published: November 2021

<p>Acute rheumatic fever is a major cause of heart disease in many parts of the world. Though it is generally considered rare in developed countries, is remains a large issue in New Zealand. Of particular concern is the prevalence of acute rheumatic fever among Maori and Pacific Island peoples. In this thesis we develop a model to simulate acute rheumatic fever in a population. We discuss the use of both deterministic methods and stochastic processes. Demographics and statistics specific to New Zealand are then used to develop the model in a way that fits specifically to the situation in New Zealand. We also consider the introduction of treatment strategies for acute rheumatic fever and discuss how risk factors can be used to focus such strategies. </p>
Blizzard City: Built Environment and Civilization in Antarctica, 1911-1961
Authors:   , Moffat-Wood Alex 
Published: November 2021

<p>This thesis investigates four Antarctic built environments between 1911 and 1961: Robert Falcon Scott’s 1910-1912 Terra Nova expedition base at Cape Evans, Ross Island; Sir Douglas Mawson’s 1911-1914 Australasian Antarctic Expedition base at Commonwealth Bay; Australia’s Mawson Station in MacRobertson Land, founded in 1954; and New Zealand’s Scott Base, also on Ross Island, founded in 1957. Examining unpublished and published diaries of expeditioners, government files and newspaper reports, this thesis demonstrates that, to the expeditioners who built and occupied them, these places created protective bastions of civilization in an extreme environment. It investigates what residents and architects (figurative and literal) thought and felt about these blizzard cities, their meaning and significance. In doing so, this study reinforces, extends, and at times challenges broader conceptions of built environment, nature, civilization, Antarctica, and their thicket of interrelationships. The first two chapters – one focused on the Heroic Era and the second on the post-WWII bases – argue that Antarctic built environments were embattled, modern sanctuaries. The extreme environment of Antarctica also demonstrated to expeditioners that built environment had plasticity, which challenged the expeditioners’ expectation of built environment being stable, durable, and impermeable. Chapter three argues that Antarctic built environment allowed expeditioners to create civilization in the wilderness, in a variety of ways. Through examining facets of occupation such as etiquette and international cooperation, the chapter argues that civilization took many forms, not all of them positive from the expeditioners’ point-of-view.</p>
"Within and Without": Exploring the Mind in the Novels of George MacDonald
Authors:   , Voorendt Saskia 
Published: November 2021

<p>George MacDonald‟s first published novel, Phantastes, is the story of a young man who enters and must negotiate his way through a fantasy landscape. This landscape, it is suggested, is one of the mind, and Anodos‟ journey through it one of self-exploration and discovery. The sustained metaphor of the mind as a territory to be actively explored through the medium of the physical world, furthermore, is argued to be the basis of several of MacDonald‟s novels. While for Anodos the mind is all, forming as it does the basis of the entire fantasy world of Fairy Land, in the author‟s numerous realist texts the interest emerges in more varied ways, including for example, portrayals of depression, madness, and drug (ab)use. While this significant and unifying feature of MacDonald‟s novels has been at times observed by critics with regard to some individual texts, it has not been directly confronted in terms of an inclusive study of his oeuvre. What this thesis demonstrates is firstly the overwhelming significance of the mind as a focal point for MacDonald‟s novels, as represented by six central texts: Phantastes, Adela Cathcart, Wilfrid Cumbermede, Malcolm, Donal Grant, and The Flight of the Shadow. It is suggested that such a consistent prioritising of the mind over the physical body lies in the author‟s own experience of ongoing physical illness and resulting confrontation with mortality. The mind becomes, for MacDonald, a means of negotiating the relationship between the realms of the physical and the spiritual. In Phantastes, for example, Anodos‟ physical experience (achieved through the genre of fantasy) of his own mind in Fairy Land, concludes with reference to the afterlife. The mind in this (and MacDonald‟s other novels) provides the means by which transcendence is achieved.</p>
"What's in a Lunchbox?": A Story About New Zealand Ideals of Health, Social Class and Ethnicity Told Through Sandwiches and the Children Who Eat Them
Authors:   , Rey Vasquez Carla 
Published: November 2021

<p>Through an ethnographic investigation of school lunchboxes, this thesis explores if and how difference and Otherness is understood by children. In three urban New Zealand primary schools I examine how children construct, affirm and/or challenge social inequalities and issues of inclusion by looking at the contents, concepts, narratives and activities related to the consumption and sharing of their lunch food. Literature dedicated to social class (Bourdieu, 1984) and identity (Rikoon, 1982; Stern, 1977) has documented the way in which food is creatively used to reaffirm unity and belonging within minority groups (Camp, 1979; Abrahams & Kalcik, 1978). In contrast to this approach, I review the role of food as a ‘safe space’ (Mercon, 2008: 5) where diversity may be allowed to symbolically exist for the purpose of affirming the unity of the nation state, while ultimately muffling deeper social differences. The thesis thus questions the assumption that food, identity and social cohesion are conceptually linked. My overall argument centres on the “humble” sandwich, which I claim is constructed as the core, dominant component of the lunchbox, mutually constituting nutritional, social class and ethnic tropes, practices and values. I assess the discourses, behaviours and symbolism that historically situates the sandwich as iconicaly or emblematically “Kiwi”, contending that via the creation of a dychotomized system (i.e. healthy, good, skinny, well-behaved, energetic, Kiwi versus junk-food, bad, fat, naughty, sick, Other) children are enculturated into the logics of work and socialized to be compliant with structures of inequality. Thus, while the sandwich appears equally accessible to all, the differences in its production can result in practices of class based distinction (Bourdieu, 1984) and ethnic exclusion (Hage, 2003). However, my analysis also reveals that children are not mere subjects of structure, but that they reproduce, challenge, mediate, and re-shape these discourses and behaviours.</p>
End of Life Care in the Home: Supporting and Sustaining Family Carers
Authors:   , Bowden-Tucker Jacqueline Rose 
Published: November 2021

<p>Palliative care services within New Zealand aim to support care for terminally ill people and their family/ whānau, regardless of their disease or place of care. Increasingly consumers prefer that this care and support, including end of life care, is provided in their own home as opposed to hospital or care institutions and current health policies support this trend. The availability of family carers is widely acknowledged as pivotal to home palliation by ensuring physical care and emotional support for the patient is available outside that provided by formal (paid) carers and palliative care professionals entering the home. Literature searched found that family carers feel under prepared for their role and desire more support and information from health care professionals. How to achieve this is less clear. When considered against the backdrop of an ageing population and geographically dispersed families, it is forecast there will be increased incidence of dying patients with complex palliative care needs and a reduced carer population that may make the preference for home death increasingly problematic. Using purposive sampling techniques, six bereaved family carers, who were enrolled with a hospice palliative care service (HPCS) and had supported end of life care of a relative at home, were recruited. Utilising qualitative descriptive methodology this study sought to identify the key conditions under which their caring contribution was sustained. Data collection was by way of semi-structured interviews that were audiotaped and transcribed. Following coding, transcripts underwent qualitative content analysis and revealed three key themes and associated subthemes relating to: perception and acquisition of caring role; sustaining the role; now and looking back. Conclusions drawn from this research offer increased understanding of the enabling factors family carers experienced as supporting them in their role and achieving a home death for their relative.</p>