bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Morphodynamic Instability Associated With Cross‐Shore Transport in the Nearshore
Authors: Falqués A. , Ribas F. , Mujal‐Colilles A. , Puig‐Polo C. 
Published: June 2021

AbstractThe existing theory for shore‐transverse rhythmic sand bars relies on morphodynamic instabilities involving the wave‐driven longshore current and rip currents. Intriguingly, transverse finger bars are common on coasts with sediment excess, something not related to those currents. Here we show that, if the actual beach profile is above the equilibrium profile, cross‐shore transport can induce an instability triggered by onshore transport together with wave refraction by the emerging bars. We use a numerical model that filters out the dynamics associated to longshore and rip currents but includes a simplified version of cross‐shore transport and is able to reproduce the formation of shore‐transverse bars. The alongshore spacing scales with the wavelength of the incident waves and the cross‐shore extent is approximately equal to the distance from shore to the depth of closure. The modeled bars compare qualitatively well with observations at El Trabucador back‐barrier beach (Ebro delta, Western Mediterranean Sea).
Modeling Responses of Polar Mesospheric Clouds to Gravity Wave and Instability Dynamics and Induced Large‐Scale Motions
Authors: Dong Wenjun , Fritts David C. , Thomas Gary E. , Lund Thomas S. 
Published: June 2021

AbstractA gravity wave (GW) model that includes influences of temperature variations and large‐scale advection on polar mesospheric cloud (PMC) brightness having variable dependence on particle radius is developed. This Complex Geometry Compressible Atmosphere Model for PMCs (CGCAM‐PMC) is described and applied here for three‐dimensional (3‐D) GW packets undergoing self‐acceleration (SA) dynamics, breaking, momentum deposition, and secondary GW (SGW) generation below and at PMC altitudes. Results reveal that GW packets exhibiting strong SA and instability dynamics can induce significant PMC advection and large‐scale transport, and cause partial or total PMC sublimation. Responses modeled include PMC signatures of GW propagation and SA dynamics, “voids” having diameters of ∼500–1,200 km, and “fronts” with horizontal extents of ∼400–800 km. A number of these features closely resemble PMC imaging by the Cloud Imaging and Particle Size (CIPS) instrument aboard the Aeronomy of Ice in the Mesosphere (AIM) satellite. Specifically, initial CGCAM‐PMC results closely approximate various CIPS images of large voids surrounded by smaller void(s) for which dynamical explanations have not been offered to date. In these cases, the GW and instabilities dynamics of the initial GW packet are responsible for formation of the large void. The smaller void(s) at the trailing edge of a large void is (are) linked to the lower‐ or higher‐altitude SGW generation and primary mean‐flow forcing. We expect an important benefit of such modeling to be the ability to infer local forcing of the mesosphere and lower thermosphere (MLT) over significant depths when CGCAM‐PMC modeling is able to reasonably replicate PMC responses.
C-reactive protein is superior to fecal biomarkers for evaluating colon-wide active inflammation in ulcerative colitis
Authors: Ishida Natsuki , Higuchi Tomohiro , Miyazu Takahiro , Tamura Satoshi , Tani Shinya , Yamade Mihoko , Iwaizumi Moriya , Hamaya Yasushi , Osawa Satoshi , Furuta Takahisa , Sugimoto Ken 
Published: June 2021

AbstractWe evaluated the association between endoscopic scores of colonic inflammation and fecal calprotectin (FC), fecal immunochemical occult blood test (FIT), and C-reactive protein (CRP) in patients with ulcerative colitis (UC). Endoscopic scores reflecting the most severe lesion [maximum Mayo Endoscopic Subscore (M-MES) and Ulcerative Colitis Endoscopic Index of Severity (UCEIS)] and those reflecting the inflammation of the entire colon [sum of MES (S-MES) and Ulcerative Colitis Colonoscopic Index of Severity (UCCIS)] were evaluated. FC, FIT, and CRP were measured, and their association with the four endoscopic scores was evaluated. Endoscopic scores of 78 complete colonoscopies (66 UC patients) were evaluated using the three biomarkers. FC and CRP tended to correlate more strongly with S-MES and UCCIS than with M-MES and UCEIS. In the M-MES 0, 1 group, compared to CRP, FC and FIT showed stronger correlations with S-MES and UCCIS. Conversely, in the M-MES 2, 3 group, only CRP was significantly correlated with each descriptor. CRP more strongly reflects colon-wide mucosal inflammation than FC and allows reliable assessment of inflammation throughout the colon in active UC.
Perturbation of resting-state network nodes preferentially propagates to structurally rather than functionally connected regions
Authors: Momi Davide , Ozdemir Recep A. , Tadayon Ehsan , Boucher Pierre , Di Domenico Alberto , Fasolo Mirco , Shafi Mouhsin M. , Pascual-Leone Alvaro , Santarnecchi Emiliano 
Published: June 2021

AbstractCombining Transcranial Magnetic Stimulation (TMS) with electroencephalography (EEG) offers the opportunity to study signal propagation dynamics at high temporal resolution in the human brain. TMS pulse induces a local effect which propagates across cortical networks engaging distant cortical and subcortical sites. However, the degree of propagation supported by the structural compared to functional connectome remains unclear. Clarifying this issue would help tailor TMS interventions to maximize target engagement. The goal of this study was to establish the contribution of functional and structural connectivity in predicting TMSinduced
signal propagation after perturbation of two distinct brain networks. For this purpose,
24 healthy individuals underwent two identical TMS-EEG visits where neuronavigated TMS pulses were delivered to nodes of the default mode network (DMN) and the dorsal attention network (DAN). The functional and structural connectivity derived from each individual stimulation spot were characterized via functional magnetic resonance imaging (fMRI) and Diffusion Weighted Imaging (DWI), and signal propagation across these two metrics was compared. Direct comparison between the signal extracted from brain regions either functionally or structurally connected to the stimulation sites, shows a stronger activation over
cortical areas connected via white matter pathways, with a minor contribution of functional projections. This pattern was not observed when analyzing spontaneous resting state EEG activity. Overall, results suggest that structural links can predict network-level response to perturbation more accurately than functional connectivity. Additionally, DWI-based estimation of propagation patterns can be used to estimate off-target engagement of other networks and possibly guide target selection to maximize specificity.
A machine learning approach to predict healthcare cost of breast cancer patients
Authors: Rakshit Pratyusha , Zaballa Onintze , Pérez Aritz , Gómez-Inhiesto Elisa , Acaiturri-Ayesta Maria T. , Lozano Jose A. 
Published: June 2021

AbstractThis paper presents a novel machine learning approach to perform an early prediction of the healthcare cost of breast cancer patients. The learning phase of our prediction method considers the following two steps: (1) in the first step, the patients are clustered taking into account the sequences of actions undergoing similar clinical activities and ensuring similar healthcare costs, and (2) a Markov chain is then learned for each group to describe the action-sequences of the patients in the cluster. A two step procedure is undertaken in the prediction phase: (1) first, the healthcare cost of a new patient’s treatment is estimated based on the average healthcare cost of its k-nearest neighbors in each group, and (2) finally, an aggregate measure of the healthcare cost estimated by each group is used as the final predicted cost.
Experiments undertaken reveal a mean absolute percentage error as small as 6%, even when half of the clinical records of a patient is available, substantiating the early prediction capability of the proposed method. Comparative analysis substantiates the superiority of the proposed algorithm over the state-of-the-art techniques.
Social dialogue triggers biobehavioral synchrony of partners' endocrine response via sex-specific, hormone-specific, attachment-specific mechanisms
Authors: Djalovski Amir , Kinreich Sivan , Zagoory-Sharon Orna , Feldman Ruth 
Published: June 2021

AbstractSocial contact is known to impact the partners' physiology and behavior but the mechanisms underpinning such inter-partner influences are far from clear. Guided by the biobehavioral synchrony conceptual frame, we examined how social dialogue shapes the partners' multi-system endocrine response as mediated by behavioral synchrony. To address sex-specific, hormone-specific, attachment-specific mechanisms, we recruited 82 man–woman pairs (N = 164 participants) in three attachment groups; long-term couples (n = 29), best friends (n = 26), and ingroup strangers (n = 27). We used salivary measures of oxytocin (OT), cortisol (CT), testosterone (T), and secretory immuglobolinA (s-IgA), biomarker of the immune system, before and after a 30-min social dialogue. Dialogue increased oxytocin and reduced cortisol and testosterone. Cross-person cross-hormone influences indicated that dialogue carries distinct effects on women and men as mediated by social behavior and attachment status. Men's baseline stress-related biomarkers showed both direct hormone-to-hormone associations and, via attachment status and behavioral synchrony, impacted women's post-dialogue biomarkers of stress, affiliation, and immunity. In contrast, women's baseline stress biomarkers linked with men's stress response only through the mediating role of behavioral synchrony. As to affiliation biomarkers, men's initial OT impacted women's OT response only through behavioral synchrony, whereas women's baseline OT was directly related to men's post-dialogue OT levels. Findings pinpoint the neuroendocrine advantage of social dialogue, suggest that women are more sensitive to signs of men's initial stress and social status, and describe behavior-based mechanisms by which human attachments create a coupled biology toward greater well-being and resilience.
Factors influencing self-selected walking speed in fibrotic interstitial lung disease
Authors: Fischer Gabriela , de Queiroz Francisco B. , Berton Danilo C. , Schons Pedro , Oliveira Henrique B. , Coertjens Marcelo , Gruet Mathieu , Peyré-Tartaruga Leonardo A. 
Published: June 2021

AbstractThis study aimed to investigate the walking economy and possible factors influencing self-selected walking speed (SSWS) in patients with fibrotic interstitial lung disease (ILD) compared to controls. In this study, 10 patients with ILD (mean age: 63.8 ± 9.2 years, forced expiratory volume in the first second: 56 ± 7% of predicted) and 10 healthy controls underwent resting pulmonary function tests, cardiopulmonary exercise, and submaximal treadmill walking tests at different speeds. The walking economy was assessed by calculating the cost-of-transport (CoT). Dynamic stability was assessed by stride-to-stride fluctuations using video recordings. Patients with ILD showed reduced peak oxygen uptake with a tachypneic breathing pattern and significant oxygen desaturation during exercise. The CoT did not differ between the groups (p = 0.680), but dyspnea and SpO2 were higher and lower, respectively, in patients with ILD at the same relative speeds. SSWS was reduced in ILD patients (2.6 ± 0.9 vs. 4.2 ± 0.4 km h−1p = 0.001) and did not correspond to the energetically optimal walking speed. Dynamic stability was significantly lower in patients with ILD than in healthy controls, mainly at lower speeds. Patients with ILD presented a similar cost of transport compared to healthy controls; however, they chose lower SSWS despite higher walking energy expenditure. Although walking stability and dyspnea were negatively affected, these factors were not associated with the slower walking speed chosen by individuals with ILD.
Lysyl oxidase inhibitors attenuate cyclosporin A-induced nephropathy in mouse
Authors: Nguyen Long T. , Saad Sonia , Shi Ying , Wang Rosy , Chou Angela S. Y. , Gill Anthony , Yao Yimin , Jarolimek Wolfgang , Pollock Carol A. 
Published: June 2021

AbstractCalcineurin inhibitors, such as Cyclosporin (CsA), are the mainstay of anti-rejection therapy in solid organ transplants but can paradoxically induce progressive nephropathy characterised by renal dysfunction and interstitial fibrosis. Lysyl oxidases (LOXs), a group of enzymes that catalyse extracellular matrix (ECM) crosslinking, were shown to implicate in tissue scarring. It is hypothesized that inhibition of these enzymes may render therapeutic effects against CsA-induced nephropathy. In this study, 6-to-8 weeks old C57BL/6 J mice were administered saline or CsA (30 mg/kg/day s.c) for 16 weeks. At 8 weeks, CsA-treated animals were divided into 5 groups respectively treated with: (1) vehicle, (2) PXS-5505 (Pan-LOX inhibitor), (3) PXS-5382 (LOX-like 2 inhibitor), (4) PXS-5505 for 4 weeks then PXS-5382 for 4 weeks (sequential therapy), and (5) Telmisartan (standard therapy). Our results indicate that CsA administration significantly increased the levels of blood urea nitrogen, glomerular and tubular injury, tubulointerstitial fibrosis, inflammation and oxidative stress in mouse kidney. These changes were associated with upregulated mRNA expression of LOX and LOXL2. Administration of Pan-LOX or LOXL2 inhibitors or the sequential therapy suppressed the expression of ECM proteins (α-SMA, FN and COL1A), matrix metalloproteases (MMP)2 and 9, inflammatory markers (TNFα and MCP-1) and TGF-β1-Smad3 signalling. Among all regimens including telmisartan, only Pan-LOX inhibitor PXS-5505 was able to attenuate uraemia. Collectively, our study suggests that Pan-LOX and LOXL2 inhibition can attenuate progressive nephropathy due to CsA administration.
Light from a firefly at temperatures considerably higher and lower than normal
Authors: Rabha Mana Mohan , Sharma Upamanyu , Barua Anurup Gohain 
Published: June 2021

AbstractBioluminescence emissions from a few species of fireflies have been studied at different temperatures. Variations in the flash-duration have been observed and interesting conclusions drawn in those studies. Here we investigate steady-state and pulsed emissions from male specimens of the Indian species Sclerotia substriata at temperatures considerably higher and lower than the ones at which they normally flash. When the temperature is raised to 34 °C, the peak wavelength gets red-shifted and the emitted pulses become the narrowest which broaden considerably thereafter for small increases in temperature; this probably indicates denaturation of the enzyme luciferase catalyzing the light-producing reaction. When the temperature is decreased to the region of 10.5–9 °C, the peak gets blue-shifted and the flash-duration increased abnormally with large fluctuation; this possibly implies cold denaturation of the luciferase. We conclude that the first or hot effect is very likely to be the reason of the species being dark-active on hot days, and the second or cold one is the probable reason for its disappearance at the onset of the winter. Our study makes the inference that these two happenings determine the temperature-tolerance, which plays a major role in the selection of the habitat for the firefly.
Epitaxial lift-off of freestanding (011) and (111) SrRuO3 thin films using a water sacrificial layer
Authors: Le Phu T. P. , ten Elshof Johan E. , Koster Gertjan 
Published: June 2021

AbstractTwo-dimensional freestanding thin films of single crystalline oxide perovskites are expected to have great potential in integration of new features to the current Si-based technology. Here, we showed the ability to create freestanding single crystalline (011)- and (111)-oriented SrRuO3 thin films using Sr3Al2O6 water-sacrificial layer. The epitaxial Sr3Al2O6(011) and Sr3Al2O6(111) layers were realized on SrTiO3(011) and SrTiO3(111), respectively. Subsequently, SrRuO3 films were epitaxially grown on these sacrificial layers. The freestanding single crystalline SrRuO3(011)pc and SrRuO3(111)pc films were successfully transferred on Si substrates, demonstrating possibilities to transfer desirable oriented oxide perovskite films on Si and arbitrary substrates.
Interactions of primaquine and chloroquine with PEGylated﻿ phosphatidylcholine liposomes
Authors: Miatmoko Andang , Nurjannah Ira , Nehru Nuril Fadilatul , Rosita Noorma , Hendradi Esti , Sari Retno , Ekowati Juni 
Published: June 2021

AbstractThis study aimed to analyze the interaction of primaquine (PQ), chloroquine (CQ), and liposomes to support the design of optimal liposomal delivery for hepatic stage malaria infectious disease. The liposomes were composed of hydrogenated soybean phosphatidylcholine, cholesterol, and distearoyl-sn-glycero-3-phosphoethanolamine-N-(methoxy[polyethyleneglycol]-2000), prepared by thin film method, then evaluated for physicochemical and spectrospic characteristics. The calcein release was further evaluated to determine the effect of drug co-loading on liposomal membrane integrity. The results showed that loading PQ and CQ into liposomes produced changes in the infrared spectra of the diester phosphate and carbonyl ester located in the polar part of the phospholipid, in addition to the alkyl group (CH2) in the nonpolar portion. Moreover, the thermogram revealed the loss of the endothermic peak of liposomes dually loaded with PQ and CQ at 186.6 °C, which is identical to that of the phospholipid. However, no crystallinity changes were detected through powder X-ray diffraction analysis. Moreover, PQ, with either single or dual loading, produced the higher calcein release profiles from the liposomes than that of CQ. The dual loading of PQ and CQ tends to interact with the polar head group of the phosphatidylcholine bilayer membrane resulted in an increase in water permeability of the liposomes.
Y disruption, autosomal hypomethylation and poor male lung cancer survival
Authors: Willis-Owen Saffron A. G. , Domingo-Sabugo Clara , Starren Elizabeth , Liang Liming , Freidin Maxim B. , Arseneault Madeleine , Zhang Youming , Lu Shir Kiong , Popat Sanjay , Lim Eric , Nicholson Andrew G. , Riazalhosseini Yasser , Lathrop Mark , Cookson William O. C. , Moffatt Miriam F. 
Published: June 2021

AbstractLung cancer is the most frequent cause of cancer death worldwide. It affects more men than women, and men generally have worse survival outcomes. We compared gene co-expression networks in affected and unaffected lung tissue from 126 consecutive patients with Stage IA–IV lung cancer undergoing surgery with curative intent. We observed marked degradation of a sex-associated transcription network in tumour tissue. This disturbance, detected in 27.7% of male tumours in the discovery dataset and 27.3% of male tumours in a further 123-sample replication dataset, was coincident with partial losses of the Y chromosome and extensive autosomal DNA hypomethylation. Central to this network was the epigenetic modifier and regulator of sexually dimorphic gene expression, KDM5D. After accounting for prognostic and epidemiological covariates including stage and histology, male patients with tumour KDM5D deficiency showed a significantly increased risk of death (Hazard Ratio [HR] 3.80, 95% CI 1.40–10.3, P = 0.009). KDM5D deficiency was confirmed as a negative prognostic indicator in a further 1100 male lung tumours (HR 1.67, 95% CI 1.4–2.0, P = 1.2 × 10–10). Our findings identify tumour deficiency of KDM5D as a prognostic marker and credible mechanism underlying sex disparity in lung cancer.
New insights of phenolic compounds from optimized fruit extract of Ficus auriculata
Authors: Shahinuzzaman M. , Akhtar Parul , Amin N. , Ahmed Yunus , Anuar Farah Hannan , Misran H. , Akhtaruzzaman Md. 
Published: June 2021

AbstractIn this study, the extraction conditions extracted maximize amounts of phenolic and bioactive compounds from the fruit extract of Ficus auriculata by using optimized response surface methodology. The antioxidant capacity was evaluated through the assay of radical scavenging ability on DPPH and ABTS as well as reducing power assays on total phenolic content (TPC). For the extraction purpose, the ultrasonic assisted extraction technique was employed. A second-order polynomial model satisfactorily fitted to the experimental findings concerning antioxidant activity (R2 = 0.968, P < 0.0001) and total phenolic content (R2 = 0.961, P < 0.0001), indicating a significant correlation between the experimental and expected value. The highest DPPH radical scavenging activity was achieved 85.20 ± 0.96% at the optimum extraction parameters of 52.5% ethanol (v/v), 40.0 °C temperature, and 22 min extraction time. Alternatively, the highest yield of total phenolic content was found 31.65 ± 0.94 mg GAE/g DF at the optimum extraction conditions. From the LC–ESI–MS profiling of the optimized extract, 18 bioactive compounds were tentatively identified, which may regulate the antioxidant activity of fruits of F. auriculata.
Light-induced levitation of ultralight carbon aerogels via temperature control
Authors: Yanagi Reo , Takemoto Ren , Ono Kenta , Ueno Tomonaga 
Published: June 2021

AbstractWe demonstrate that ultralight carbon aerogels with skeletal densities lesser than the air density can levitate in air, based on Archimedes' principle, when heated with light. Porous materials, such as aerogels, facilitate the fabrication of materials with density less than that of air. However, their apparent density increases because of the air inside the materials, and therefore, they cannot levitate in air under normal conditions. Ultralight carbon aerogels, fabricated using carbon nanotubes, have excellent light absorption properties and can be quickly heated by a lamp owing to their small heat capacity. In this study, an ultralight carbon aerogel was heated with a halogen lamp and levitated in air by expanding the air inside as well as selectively reducing its density. We also show that the levitation of the ultralight carbon aerogel can be easily controlled by turning the lamp on and off. These findings are expected to be useful for various applications of aerogels, such as in communication and transportation through the sky.