bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pendampingan UMKM Menuju Digitalisasi Marketing Upaya Kebangkitan di Era New Normal
Authors: Maydiantoro Albet , Jaya Muhammad Thoha B.Sampurna , Hestiningtyas Widya , Rahmawati Rahmawati 
Published: December 2021

ABSTRAK Pelaksanaan Pengabdian Masyarakat dengan Judul Pendampingan UMKM Menuju Digitalisasi Marketing Upaya Kebangkitan di era new normal (Masyarakat Terdampak Tsunami Anak Gunung Krakatau) di desa Kunjir, Lampung Selatan mempunyai tujuan untuk meningkatkan kompetensi para pelaku UMKM di desa Kunjir Kabupaten Lampung Selatan dalam memanfaatkan teknologi untuk mengembangkan usaha yang mereka miliki agar operasi bisnis relevan dengan perkembangan zaman. Metode pengabdian masyarakat yang digunakan ialah dengan tahapan identifikasi awal (Fase Pra Pendampingan), kemudian dilanjutkan Fase pendampingan (pelatihan dan Pembimbingan) dan yang terakhir ialah Pasca Pendampingan. Berdasarkan pelaksanaan kegiatan pengabdian kepada masyarakat yang telah dilakukan diperoleh hasil bahwa terdapat peningkatan pengetahuan dan keterampilan pelaku UMKM tentang digitalisasi marketing. Kemudian diperoleh data akhir bahwa sebesar 87 % pelaku UMKM di Desa Kunjir Kabupaten Lampung Selatan dapat membuat media pemasaran secara online melalui aplikasi Marketplace di Facebook, Shopee, Bukalapak, dan WhatsApp, namun terdapat 13 % pelaku UMKM belum dapat membuat media pemasaran secara online. Kata Kunci: UMKM; Digitalisasi; Marketing; Lampung Selatan ABSTRACT Implementation of Community Service with the title MSME Assistance Towards Marketing Digitalization Awakening Efforts in the New Normal (Communities Affected by the Tsunami of the Children of Mount Krakatau) in Kunjir village, South Lampung has the aim of increasing the competence of MSME actors in Kunjir village, South Lampung regency in utilizing technology to develop the business they have so that business operations are relevant to the times. The community service method used is the initial identification stage (Pre Mentoring Phase), followed by the Mentoring Phase (training and Guidance), and the last is Post Mentoring. Based on the implementation of community service activities that have been carried out, the results show an increase in the knowledge and skills of MSME actors regarding the digitalization of marketing. Then the final data obtained that 87% of MSME actors in Kunjir Village, South Lampung Regency can create online marketing media through the Marketplace application on Facebook, Shopee, Bukalapak, and WhatsApp, but there are 13% of MSME actors who have not been able to create online marketing media. Keywords: MSM; Digitalization; Marketing; South Lampung
Faktor yang Berhubungan dengan Tekanan Darah Pekerja yang Terpajan Kebisingan pada Pekerja di PT Industri Kapal Indonesia (Persero) Makassar
Authors: Syarif Nisrina , Suharni A. Fachrin  , Andi Nurlinda  
Published: December 2021

Pekerja bagian produksi adalah salah satu pekerja yang mempunyai resiko terkena tekanan darah tinggi maupun tekanan darah rendah yang sering dijumpai dalam masyarakat. Tekanan darah tinggi dapat disebabkan oleh berbagai macam faktor, salah satunya adalah kebisingan. Kebisingan Kebisingan merupakan suara yang menyebabkan gangguan kesehatan dan konsekuensi sosial yang merugikan. Penelitian ini bertujuan untuk Mengetahui Hubungan Antara Masa Kerja, Umur Dan Lama Kerja Dengan Tekanan Darah pada Pekerja Di PT.Industri Kapal Indonesia (Persero) Makassar Tahun 2020 dengan menggunakan metode observasional analitik dengan pendekatan cross sectional study. Hasil ini menunjukkan terdapat tidak ada hubungan antara masa kerja dengan tekanan darah nilai p = 0,586, tidak ada hubungan antara umur dengan tekanan darah nilai p = 0,249, ada hubungan antara lama kerja dengan tekanan darah nilai p= 0,004, ada hubungan antara intensitas kebisingan dengan tekanan darah nilai p= 0,001.
МІСЦЕ ІНШОМОВНОЇ КОМУНІКАТИВНОЇ КОМПЕТЕНЦІЇ В ПРОФЕСІЙНІЙ КОМПЕТЕНТНОСТІ ДЕРЖАВНОГО СЛУЖБОВЦЯ
Authors: Шестопалова Світлана 
Published: December 2021

Визначення місця іншомовної комунікативної компетенції в професійній компетентності сучасного державного службовця проблематика нашого дослідження. Здійснено детальний аналіз вітчизняних наукових праць та законодавчої (нормативної) бази. Встановлено, що важливою умовою для вступу на державну службу та подальшого її проходження на всіх етапах є відповідний рівень професійної компетентності державного службовця. Від рівня професійної компетентності кожного державного службовця залежить ефективність функціонування державної служби загалом. Комунікативна компетенція висвітлена як вагома складова професійної компетентності. Враховуючи необхідність залучення державного службовця до міжнародних відносин, постійного перебування в міжнародному інформаційному просторі, комунікативні навички та достатній рівень знання іноземної мови професійного спрямування стають вирішальними у даному питанні та дають впливають на формування та розвиток іншомовної комунікативної компетенції. З метою розкриття сутності цієї компетенції, наголошено на основних її компонентах та надано пояснення до кожного з них. Доведено, що формування та розвиток іншомовної комунікативної компетенції відбувається одночасно з проходженням професійного навчання державних службовців. Наведено приклади започаткованих на державному рівні програм з вивчення іноземної мови (англійської), до яких залучаються державні службовці. Також зазначається, що самоосвіта та саморозвиток мають не менш вагомий вплив на навчання, що надає можливість самостійно планувати, коригувати, координувати своє навчання та самостійно впливати на формування іншомовної комунікативної компетенції як складової своєї професійної компетентності. Зазначено, що іншомовна комунікативна компетенція посідає чільне місце в професійній компетентності сучасного державного службовця та сприяє застосуванню отриманих під час професійного навчання знань та вмінь у професійній діяльності, використовуючи спеціальні лінгвістичні засоби.
LDL-Based Lipid Nanoparticle Derived for Blood Plasma Accumulates Preferentially in Atherosclerotic Plaque
Authors: Boada Christian A. , Zinger Assaf , Rohen Scott , Martinez Jonathan O. , Evangelopoulos Michael , Molinaro Roberto , Lu Madeleine , Villarreal-Leal Ramiro Alejandro , Giordano Federica , Sushnitha Manuela , De Rosa Enrica , Simonsen Jens B. , Shevkoplyas Sergey , Taraballi Francesca , Tasciotti Ennio 
Published: December 2021

Apolipoprotein-based drug delivery is a promising approach to develop safe nanoparticles capable of targeted drug delivery for various diseases. In this work, we have synthesized a lipid-based nanoparticle (NPs) that we have called “Aposomes” presenting native apolipoprotein B-100 (apoB-100), the primary protein present in Low-Density Lipoproteins (LDL) on its surface. The aposomes were synthesized from LDL isolated from blood plasma using a microfluidic approach. The synthesized aposomes had a diameter of 91 ± 4 nm and a neutral surface charge of 0.7 mV ± mV. Protein analysis using western blot and flow cytometry confirmed the presence of apoB-100 on the nanoparticle’s surface. Furthermore, Aposomes retained liposomes’ drug loading capabilities, demonstrating a prolonged release curve with ∼80% cargo release at 4 hours. Considering the natural tropism of LDL towards the atherosclerotic plaques, we evaluated the biological properties of aposomes in a mouse model of advanced atherosclerosis. We observed a ∼20-fold increase in targeting of plaques when comparing aposomes to control liposomes. Additionally, aposomes presented a favorable biocompatibility profile that showed no deviation from typical values in liver toxicity markers (i.e., LDH, ALT, AST, Cholesterol). The results of this study demonstrate the possibilities of using apolipoprotein-based approaches to create nanoparticles with active targeting capabilities and could be the basis for future cardiovascular therapies.
Identification of lncRNA and mRNA Expression Profile in Relapsed Graves’ Disease
Authors: Yao Qiuming , Song Zhenyu , Wang Bin , Jia Xi , Song Ronghua , Zhang Jinan 
Published: December 2021

Background: Graves’ disease (GD) is a common autoimmune disease, and its pathogenesis is unclear. Studies have found that the occurrence of GD is related to the immune disorder caused by the interaction of genetic susceptibility and environmental factors. The CD4+ T cell subset is closely related to the immune disorder of GD. LncRNAs are RNA molecules with a length of more than 200 nt and are involved in a variety of autoimmune diseases. However, the roles of lncRNAs in recurrent GD are still elusive. The purpose of this study is to identify lncRNA and mRNA expression profile in relapsed Graves’ disease.Method: CD4+ T cells from 12 recurrent GD and 8 healthy controls were collected for high-throughput sequencing. The gene-weighted co-expression network analysis (WGCNA) was used to construct the co-expression module relevant to recurrent GD, and the key genes in the module were verified by RT-PCR.Results: There are 602 upregulated lncRNAs and 734 downregulated lncRNAs in CD4+ T cells in recurrent GD patients compared with the healthy controls. The module most relevant to GD recurrence was constructed using WGCNA, and the key genes in the module were verified by RT-PCR. We found that the expression of RPL8, OAS2, NFAT5, DROSHA, NONHSAT093153.2, NONHSAT118924.2, and NONHSAT209004.1 was significantly decreased in GD group (p &lt; 0.001, p &lt; 0.001, p &lt; 0.01, p &lt; 0.05, p &lt; 0.001, p &lt; 0.05, and p &lt; 0.01, respectively).Conclusion: LncRNAs are closely related to the recurrence of GD. For the first time, we constructed the expression profile of lncRNAs and mRNAs in CD4+ T cells in recurrent GD patients.
Effect of NPC1L1 and HMGCR Genetic Variants With Premature Triple-Vessel Coronary Disease
Authors: Zhao Xueyan , Xu Jingjing , Tang Xiaofang , Huang Keyong , Li Jiawen , Liu Ru , Jiang Lin , Zhang Yin , Wang Dong , Sun Kai , Xu Bo , Zhao Wei , Hui Rutai , Gao Runlin , Song Lei , Yuan Jinqing 
Published: December 2021

Background: Both Niemann-Pick C1-like 1 (NPC1L1) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) play a key role on dyslipidaemia. We aim to evaluate whether NPC1L1 and HMGCR genetic variants are associated with susceptibility of premature triple-vessel disease (PTVD).Methods: Four single-nucleotide polymorphisms (SNPs) (rs11763759, rs4720470, rs2072183, and rs2073547) of NPC1L1; and three SNPs (rs12916, rs2303151, and rs4629571) of HMGCR were genotyped in 872 PTVD patients (males ≤ 50 years old and females ≤ 60 years old), and 401 healthy controls.Results: After adjusting for age and sex, rs12916 of HMGCR was associated with the risk of PTVD in dominance model [odds ratio (OR) = 1.68, 95% confidence intervals (CI): 1.29–2.18, P &lt; 0.001], recessive model (OR = 1.43, 95% CI: 1.08–1.90, P = 0.013) and codominant model (OR = 1.38, 95% CI: 1.17–1.63, P &lt; 0.001); meanwhile, rs4720470 of NPC1L1 was related to increased risk of PTVD in recessive model (OR = 1.74, 95% CI: 1.14–2.74, P = 0.013). Patients who carried both variant rs4720470 and rs12916 also had the risk of PTVD (P &lt; 0.001); however, there were no correlation between these SNPs and the SNYTAX score (all P &gt; 0.05).Conclusions: This is the first report that rs4720470 is a novel polymorphism of the NPC1L1 gene associated with PTVD, and rs12916 of HMGCR gene appears to be a strong genetic marker of PTVD. Our study may improve the early warning, therapeutic strategies and drug development of PTVD.
Malnutrition and Frailty Are Critical Determinants of 6-Month Outcome in Hospitalized Elderly Patients With Heart Failure Harboring Surgically Untreated Functional Mitral Regurgitation
Authors: Miura Masakazu , Okuda Shinichi , Murata Kazuhiro , Nagai Hitoshi , Ueyama Takeshi , Nakao Fumiaki , Shimokawa Mototsugu , Yamamoto Takeshi , Ikeda Yasuhiro 
Published: December 2021

Background: Hospitalized patients with acute decompensated heart failure (ADHF) frequently exhibit aggravating mitral regurgitation (MR). Those patients do not always undergo surgical mitral valve repair, but particularly in the elderly, they are often treated by conservative medical therapy. This study was aimed to investigate factors affecting 6-month outcomes in hospitalized patients with heart failure (HF) harboring surgically untreated MR.Methods: We screened the presence of MR in hospitalized patients with HF between September 2017 and May 2020 in the Yamaguchi Prefectural Grand Medical (YPGM) center. At the time of discharge of these patients, individuals with surgically unoperated MR, including primary and secondary origin, were consequently recruited to this single-center prospective cohort study. The patients with severe MR who undergo surgical mitral valve treatment were not included in this study. The primary endpoint was all-cause readmission or all-cause death and the secondary endpoint was HF-related endpoint at 6 months after discharge. The Cox proportional hazard regression analyses were employed to assess the predictors for the composite endpoint.Results: Overall, 489 patients with ADHF were admitted to the YPGM center. Of those, 146 patients (30% of total patients with HF) (median age 83.5 years, 69 men) were identified as harboring grade II MR or greater. Consequently, all the recruited patients were diagnosed as functional MR. During a median follow-up of 186.0 days, a total of 55 patients (38%) reached the primary or secondary endpoints (HF death and readmission in 31 patients, other in 24 patients). As a result of multivariate analysis, geriatric nutritional risk index [hazard ratio (HR) = 0.932; 95% CI = 0.887–0.979, p = 0.005], age (HR = 1.058; 95% CI = 1.006–1.112, p = 0.027), and left ventricular ejection fraction (HR = 0.971; 95% CI = 0.945–0.997, p = 0.030) were independent predictors of all-cause death or all-cause admission. Body mass index (HR = 0.793; 95% CI = 0.614–0.890, p = 0.001) and ischemic heart disease etiology (HR = 2.732; 95% CI = 1.056–7.067, p = 0.038) were also independent predictors of the HF-related endpoints.Conclusion: Malnutrition and underweight were substantial predictors of adverse outcomes in elderly patients with HF harboring surgically untreated moderate-to-severe functional MR.
Ovarian Endometrioma Negatively Impacts Oocyte Quality and Quantity But Not Pregnancy Outcomes in Women Undergoing IVF/ICSI Treatment: A Retrospective Cohort Study
Authors: Wu Yaoqiu , Yang Rong , Lan Jie , Lin Haiyan , Jiao Xuedan , Zhang Qingxue 
Published: December 2021

PurposeTo determine the impact of ovarian endometrioma per se on in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes.MethodsThis retrospective study was conducted using two groups. The endometrioma group consisted of 862 women with infertility who had ovarian endometriomas and underwent their first ovarian stimulation for IVF/ICSI treatment between January 2011 to December 2019 at a public university hospital. A non-endometrioma comparison group, comprising 862 women with other infertility factors, was matched according to maternal age, body mass index (BMI), and infertility duration. Ovarian reserve and response and IVF/ICSI and pregnancy outcomes between the two groups were analyzed. Multivariate logistic regression (MLR) analysis was conducted on the basis of clinical covariates assessed for their association with live birth.ResultsThe results showed that significantly lower antral follicle count (AFC), anti-Müllerian hormone (AMH), ovarian sensitivity index (OSI), oocyte maturation and fertilization rates, blastocyst rate, number of oocytes retrieved, and available embryos were found in women with endometrioma compared with the control, respectively (P &lt; 0.05). The cumulative live birth rate per patient in women with endometrioma was lower than that of women without endometrioma (39.32% vs. 46.87%, P = 0.002). In women with endometrioma, those who underwent surgical intervention prior to IVF/ICSI treatment had higher maturation (86.03% vs. 83.42%, P = 0.003), fertilization (78.16% vs. 74.93%, P = 0.004), and top-quality embryo rates (42.94% vs. 39.93%, P = 0.097) but had fewer oocytes retrieved (8.01 ± 5.70 vs. 9.12 ± 6.69, P = 0.013) than women without surgery. However, live birth rates were comparable between women with endometrioma and women in the control group, regardless of whether they had a prior history of ovarian surgery. MLR analysis showed no correlation between endometrioma per se and live birth after being adjusted for number of top-quality embryos transferred and stage of embryo transfer.ConclusionsThe data from this study supported the conclusion that ovarian endometrioma negatively impacts oocyte quality and quantity, but not overall pregnancy outcomes, in women undergoing IVF/ICSI treatment. Endometrioma lowers the cumulative live birth rate by decreasing the number of embryos. Surgical excision of endometrioma prior to IVF/ICSI can partly improve oocyte maturation and fertilization rates but not pregnancy outcomes.
Bone Turnover Markers in Response to Ultrasound-Guided Microwave Ablation for Primary Hyperparathyroidism
Authors: Ni Wenjing , Yuan Yue , Chu Xiaoqiu , Chen Guofang , Han Xue , Li Jie , Wu Xinping , Wang Jianhua , Liu Chao , Xu Shuhang 
Published: December 2021

ObjectiveTo assess the efficacy and safety of ultrasound-guided microwave ablation (MWA) in the treatment of primary hyperparathyroidism (PHPT), and to investigate whether MWA can improve the bone turnover and renal function.MethodsA total of 20 consecutive PHPT patients with 21 parathyroid lesions treated with MWA in our center from May 2019 to March 2021 were recruited in this study. Serum parathyroid hormone (PTH), calcium and phosphorus levels before MWA and at 20 minutes, 4 hours, 1 day, 3 months, 6 months and 12 months after MWA were measured. Bone turnover biomarkers, renal function and lesion volume with volume reduction rate (VRR) before MWA and at the last follow-up were compared. Any complication related with MWA was evaluated. The technical and clinical success rates of MWA in the treatment of PHPT were calculated. Clinical success was defined as normal serum PTH and calcium without PHPT-associated manifestations at more than 6 months after ablation. Technical success was defined as complete ablation indicated by immediate postoperative contrast-enhanced ultrasound.ResultsThe serum PTH, calcium and phosphorus levels at their respective follow-up time points dropped significantly after MWA (P &lt;0.05). The volume of parathyroid lesions at the final examination was significantly reduced, compared with pre-ablation volume (P &lt;0.001), with a median VRR reaching 89%. The technical and clinical success rates were 100% and 63.6%, respectively. Substantial changes of bone turnover biomarkers were observed before and after MWA (P &lt;0.05), but the differences in renal function were not statistically significant. No major complications were reported in all cases. Pre-MWA serum PTH, lesion volume, maximum diameter of lesion and ablation time were significantly different between patients with successful and failed MWA.ConclusionsPHPT can be effectively and safely treated by ultrasound-guided MWA, as proven by drop in serum PTH and reduction in the volume of parathyroid adenomas. Besides, MWA can impede bone remodeling to suppress hyperparathyroidism in the condition of PHPT.
The Systematic Landscape of Nectin Family and Nectin-Like Molecules: Functions and Prognostic Value in Low Grade Glioma
Authors: Han Yunhe , Zou Cunyi , Zhu Chen , Liu Tianqi , Shen Shuai , Cheng Peng , Cheng Wen , Wu Anhua 
Published: December 2021

Objective: Nectin and nectin-like molecules (Necls) are molecules that are involved in cell–cell adhesion and other vital cellular processes. This study aimed to determine the expression and prognostic value of nectin and Necls in low grade glioma (LGG).Materials and Methods: Differentially expressed nectin and Necls in LGG samples and the relationship of nectin family and Necls expression with prognosis, clinicopathological parameters, and survival were explored using The Cancer Genome Atlas (TCGA), the Chinese Glioma Genome Atlas (CGGA), and Repository of Molecular Brain Neoplasia Data (REMBRANDT) databases. Univariate and multivariate Cox analysis models were performed to construct the prognosis-related gene signature. Kaplan-Meier curves and time-dependent receiver operating characteristic (ROC) curves and multivariate Cox regression analysis, were utilized to evaluate the prognostic capacity of the four-gene signature. Gene ontology (GO)enrichment analysis and Gene Set Enrichment Analyses (GSEA) were performed to further understand the underlying molecular mechanisms. The Tumor Immune Estimation Resource (TIMER) was used to explore the relationship between the four-gene signature and tumor immune infiltration.Results: Several nectin and Necls were differentially expressed in LGG. Kaplan–Meier survival analyses and Univariate Cox regression showed patients with high expression of NECTIN2 and PVR and low expression of CADM2 and NECTIN1 had worse prognosis among TCGA, CGGA, and REMBRANDT database. Then, a novel four-gene signature was built for LGG prognosis prediction. ROC curves, KM survival analyses, and multivariate COX regression indicated the new signature was an independent prognostic indicator for overall survival. Finally, GSEA and GO enrichment analyses revealed that immune-related pathways participate in the molecular mechanisms. The risk score had a strong negative correlation with tumor purity and data of TIMER showed different immune cell proportions (macrophage and myeloid dendritic cell) between high- and low-risk groups. Additionally, signature scores were positively related to multiple immune-related biomarkers (IL 2, IL8 and IFNγ).Conclusion: Our results offer an extensive analysis of nectin and Necls levels and a four-gene model for prognostic prediction in LGG, providing insights for further investigation of CADM2, NECTIN1/2, and PVR as potential clinical and immune targets in LGG.
A Novel Nine-Gene Signature Associated With Immune Infiltration for Predicting Prognosis in Hepatocellular Carcinoma
Authors: Liu Rongqiang , Jiang ZeKun , Kong Weihao , Zheng Shiyang , Dai Tianxing , Wang Guoying 
Published: December 2021

Background: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide, and its prognosis remains unsatisfactory. The identification of new and effective markers is helpful for better predicting the prognosis of patients with HCC and for conducting individualized management. The oncogene Aurora kinase A (AURKA) is involved in a variety of tumors; however, its role in liver cancer is poorly understood. The aim of this study was to establish AURKA-related gene signatures for predicting the prognosis of patients with HCC.Methods: We first analyzed the expression of AURKA in liver cancer and its prognostic significance in different data sets. Subsequently, we selected genes with prognostic value related to AURKA and constructed a gene signature based on them. The predictive ability of the gene signature was tested using the HCC cohort development and verification data sets. A nomogram was constructed by integrating the risk score and clinicopathological characteristics. Finally, the influence of the gene signature on the immune microenvironment in HCC was comprehensively analyzed.Results: We found that AURKA was highly expressed in HCC, and it exhibited prognostic value. We selected eight AURKA-related genes with prognostic value through the protein-protein interaction network and successfully constructed a gene signature. The nine-gene signature could effectively stratify the risk of patients with HCC and demonstrated a good ability in predicting survival. The nomogram showed good discrimination and consistency of risk scores. In addition, the high-risk group showed a higher percentage of immune cell infiltration (i.e., macrophages, myeloid dendritic cells, neutrophils, and CD4+T cells). Moreover, the immune checkpoints SIGLEC15, TIGIT, CD274, HAVCR2, and PDCD1LG2 were also higher in the high-risk group versus the low-risk group.Conclusions: This gene signature may be useful prognostic markers and therapeutic targets in patients with HCC.