bluuebunny/crossref_metadata_2025_split huggingface dataset:
On application of a linear fractional creep and creep rupture strength model in simulation of long-term destruction of typical structural elements in an active medium
Authors: Фомин Леонид Викторович 
Published: January 2021

Исследуется длительное разрушение оболочки и пластины при ползучести в активной среде в условиях нестационарного сложного напряженного состояния. Учет влияния среды на время до разрушения осуществляется с помощью введения в определяющие и кинетические дробно-линейные соотношения функции от интегрально средней концентрации среды. Проведено сравнение времен до разрушения при использовании скалярного и векторного параметров поврежденности. Определены особенности использования дробно-линейной модели для описания процессов длительного разрушения.
The long-term destruction of the shell and plate during creep in the active medium under the conditions of an unsteady complex stress state is investigated. The influence of the medium on the time to fracture is taken into account by introducing a function of the integral average concentration of the medium into the constitutive and kinetic linear-fractional relationships. Comparison of the times to failure using the scalar and vector damage parameters is carried out. The features of using a linear-fractional model to describe long-term fracture processes are determined.
Metaharmonic potentials in mechanics of micropolar media
Authors: Радаев Юрий Николаевич 
Published: January 2021

Рассматриваются дифференциальные уравнения для потенциалов перемещений и микровращений, замещающие связанные векторные дифференциальные уравнения линейной теории микрополярной упругости. Исследуются только гармонические зависимости от времени. Опираясь на представление векторов перемещений и микровращений с помощью четырех винтовых векторов, обеспечивающее выполнимость связанных векторных дифференциальных уравнений линейной теории микрополярной упругости, получены новые представления в терминах двух метагармонических векторных полей. Проблема нахождения вихревых составляющих перемещений и микровращений приводится к решению двух несвязанных между собой векторных метагармонических уравнений. Часто указанные уравнения могут быть решены разделением пространственных переменных. Поэтому полученные представления могут находить применение в прикладных задачах механики деформируемого твердого тела, связанных с распространением гармонических волн перемещений и микровращений, характеризующихся заданным азимутальным числом, вдоль длинных цилиндрических волноводов.
The coupled vector differential equations of the linear theory of micropolar elasticity formulated in terms of displacements and micro-rotations are studied. A harmonic dependence of the physical fields on time is assumed. By employing the displacements and micro-rotations representation formula in the terms of four screw vectors a new representation based on two metaharmonic vectors are obtained. Thus the problem of determination of the vortex parts of the displacement and micro-rotation fields is reduced to solution of two uncoupled vector metaharmonic equations. The latter can be oftenly solved by the separation of variables technique. For this reason obtained results can be applied to various problems of the micropolar elasticity related to harmonic wave propagation in waveguides. In particular this is true for waves of a given azimuthal number in a long cylindrical waveguide.
Finite strain of cylindrical body rotating with acceleration
Authors: Фирсов Сергей Викторович 
Published: January 2021

Рассмотрена задача деформирования цилиндрического тела вращающегося вокруг центральной оси с ускорением. Получены итоговая система уравнений, описывающая данный процесс в рамках математической модели теории больших деформаций при наличии необратимых деформаций. Рассмотрен частный случай упругого деформирования, для которого приведены выражения для расчёта напряжений и деформаций в среде, а также итоговые дифференциальные соотношения, решение которых необходимо искать.
The problem of deformation of cylindrical body rotating with acceleration is considered. The system of equations describing this process in general case with non zero irreversible strains in frame of finite strain theory was obtained. A particular case of elastic deformation was considered and the resulting equations for this case was obtained.
8.7. ONTOLOGY OF THE SOCIO-ECONOMIC SYSTEM IN THE CONTEXT OF MODERNIZATION OF REGIONAL DEVELOPMENT STRATEGIES
Authors: Хашеми Д.М.Р. 
Published: January 2021

В статье исследуется сущность социоэкономической системы с позиции возможной модернизации стратегирования направлений регионального развития; выделяются основные различия между социоэкономикой и экономической социологией; раскрывается динамический характер развития как значимая черта социоэкономической системы в постоянных изменениях показателей и фаз циклов.
The article examines the essence of the socio-economic system from the perspective of possible modernization of regional development strategies; highlights the main differences between socio-Economics and economic sociology; reveals the dynamic nature of development as a significant feature of the socio-economic system in constant changes in indicators and phases of cycles.
3.1. VALUE ANALYSIS IN CONSTRUCTION PROJECT MANAGEMENT
Authors: Лю Ю. , Зуб А.Т. 
Published: January 2021

Функционально-стоимостный анализ (или стоимостная инженерия) – это относительно новая технология управления, которая надежно реализует необходимые функции продукта с наименьшими затратами в течение жизненного цикла проекта и фокусируется на организованных действиях функционального анализа, который оптимизирует затраты и производительность. Конечной целью любой деятельности является улучшение функции ценности и снижение затрат на ее достижение, а способ достижения этого – сравнение альтернатив и выбор лучшей из предложенных на основе творческих методов. Стоимостная инженерия применяется в управлении строительными проектами. Ее основным применением является анализ качества проекта, стоимости и времени на его реализацию для повышения эффективности и результативности управления проектами.
Value Analysis (Value engineering) is a relatively new management technology, based on the lowest Life Cost Cycle (LCC) and focuses on organized functional analysis activities that optimize costs and performance. The ultimate goal of the activity is to improve the value function and reduce costs, and the key is to compare and choose the best plan with creative thinking methods. Value engineering is applied to the management of construction projects. The most basic application is a qualitative analysis of project quality, cost and time, using the "preparation – analysis – innovation – implementation" stages of work to improve the efficiency and effectiveness of project
8.3. AREA IMPROVEMENT AS A SOСIAL-ECONOMIC BASIS FOR THE DEVELOPMENT OF TOURISM OF THE VOLGOGRAD REGION
Authors: Косульникова Т.Л. , Сизенева Л.А. , Шарапов Д.Ю. 
Published: January 2021

Одним из факторов успешного развития туризма и повышения туристкой привлекательности региона является формирование благоприятной городской среды. Анализ показателей, характеризующих уровень развития городской среды городов Волгоградской области, выявил, что в 2018 году ни один город региона не набрал необходимое количество баллов для присвоения статуса «Город с благоприятной городской средой», а в 2019 г. в число таких городов вошел Камышин. Однако в настоящее время в регионе активно реализуются проекты по благоустройству территорий и используются практики развития объектов туристско-рекреационного назначения, апробированные в регионах, достигших существенных успехов в развитии туризма: реализуется проект «Создание современного туристско-рекреационного кластера в пойме р. Царица «Новая пойма»; пять городов региона завоевали гранты Всероссийского конкурса благоустройства (Михайловка, Урюпинск, Николаевск, Палласовка и Петров Вал); благоустройство парка «Заречный» г. Фролово.
One of the factors for the successful development of tourism and increasing the tourist attractiveness of the region is the formation of a favorable urban environment. An analysis of indicators characterizing the level of development of the urban environment of the cities of the Volgograd region revealed that in 2018 not a single town in the region scored the required number of points to be awarded the status of "City with a favorable urban environment", and in 2019 Kamyshin was included in the number of such towns. However, at present, the region is actively implementing projects of the area improvement and the practice of developing objects for tourist and recreational purposes, tested in regions that have achieved significant success in the development of tourism, are using: the project “Creation of a modern tourist and recreational cluster in the floodplain of the river Tsatitsa "New floodplain"; five cities in the region won grants from the All-Russian landscaping competition (Mikhailovka, Uryupinsk, Nikolaevsk, Pallasovka and Petrov Val); a large improvement project in the city of Frolovo has been completed.
7.2. STRUCTURING THE PROCESS OF INDUSTRIAL ENTERPRISES INNOVATIVE ACTIVITY MANAGING
Authors: Васяйчева В.А. 
Published: January 2021

Данная статья посвящена углубленному изучению содержания подпроцессов управления инновационной деятельностью. Сформированные в результате исследования модели отражают их функциональный состав и визуализируют логические взаимосвязи между ними. Их использование на практике позволит руководству промышленных предприятий рационализировать работу подразделений, задействованных в инновационной деятельности, оптимизировать сроки выполнения отдельных операций, исключить дублирование функций и повысить эффективность инновационного менеджмента в целом.
This article is devoted to an in-depth study of the content of subprocesses of innovation management. The models formed as a result of the study reflect their functionally composition and visualize the logical relationships between them. Their use in practice will allow the management of industrial enterprises to streamline the work of units involved in innovation, optimize the timing of individual operations, eliminate duplication of functions and increase the effectiveness of innovation management as a whole.
Imaging Evidence for Solar Wind Outflows Originating from a Coronal Mass Ejection Footpoint
Authors: Lörinčík Juraj , Dudík Jaroslav , Aulanier Guillaume , Schmieder Brigitte , Golub Leon 
Published: January 2021

Abstract
We report on Atmospheric Imaging Assembly observations of plasma outflows originating in a coronal dimming during a 2015 April 28 filament eruption. After the filament started to erupt, two flare ribbons formed, one of which had a well-visible hook enclosing a core (twin) dimming region. Along multiple funnels located in this dimming, a motion of plasma directed outward started to be visible in the 171 and 193 Å filter channels of the instrument. In time–distance diagrams, this motion generated a strip-like pattern, which lasted for more than 5 hr and whose characteristics did not change along the funnel. We therefore suggest the motion is a signature of outflows corresponding to velocities ranging between ≈70 and 140 km s−1. Interestingly, the pattern of the outflows and their velocities were found to be similar to those we observed in a neighboring ordinary coronal hole. Therefore, the outflows were most likely a signature of a coronal mass ejection–induced solar wind flowing along the open-field structures rooted in the dimming region. Further, the evolution of the hook encircling the dimming region was examined in the context of the latest predictions imposed for 3D magnetic reconnection. The observations indicate that the filament’s footpoints were, during their transformation to the dimming region, reconnecting with surrounding canopies. To our knowledge, our observations present the first imaging evidence for outflows of plasma from a dimming region.
Nebular Models of Sub-Chandrasekhar Mass Type Ia Supernovae: Clues to the Origin of Ca-rich Transients
Authors: Polin Abigail , Nugent Peter , Kasen Daniel 
Published: January 2021

Abstract
We use non-local thermal equilibrium radiative transport modeling to examine observational signatures of sub-Chandrasekhar mass double detonation explosions in the nebular phase. Results range from spectra that look like typical and subluminous Type Ia supernovae (SNe) for higher mass progenitors to spectra that look like Ca-rich transients for lower mass progenitors. This ignition mechanism produces an inherent relationship between emission features and the progenitor mass as the ratio of the nebular [Ca ii]/[Fe iii] emission lines increases with decreasing white dwarf mass. Examining the [Ca ii]/[Fe iii] nebular line ratio in a sample of observed SNe we find further evidence for the two distinct classes of SNe Ia identified in Polin et al. by their relationship between Si ii velocity and B-band magnitude, both at time of peak brightness. This suggests that SNe Ia arise from more than one progenitor channel, and provides an empirical method for classifying events based on their physical origin. Furthermore, we provide insight to the mysterious origin of Ca-rich transients. Low-mass double detonation models with only a small mass fraction of Ca (1%) produce nebular spectra that cool primarily through forbidden [Ca ii] emission.
9-Hydroxy-6,7-dimethoxydalbergiquinol suppresses hydrogen peroxide-induced senescence in human dermal fibroblasts through induction of sirtuin-1 expression
Authors: Lim Seok-Hee , Li Bing Si , Zhu Ri Zhe , Choi Byung-Min 
Published: January 2021

Objective:
To investigate the potential anti-aging mechanism of 9-hydroxy-6,7-dimethoxydalbergiquinol (HDDQ) on hydrogen peroxide (H2O2)-induced oxidative stress in human dermal fibroblasts (HDFs).

Methods:
The effect of HDDQ on cell viability was assessed by MTT assay, and the effects of HDDQ on senescence-like phenotypes were determined by senescence-associated β-galactosidase (SA-β-gal) staining, Western blotting analysis, and a cell proliferation assay. The expression level and activity of sirtuin-1 (SIRT1) induced by HDDQ were also measured.

Results:
HDDQ reversed senescence-like phenotypes in the oxidant-challenged model, through reducing SA-β-gal activity and promoting cell growth. Meanwhile, decreases in ac-p53, p21
Cip1/WAF1
, and p16
Ink4a
and an increase in pRb were observed. HDDQ induced the expression of SIRT1 in a concentration- and time-dependent manner. Moreover, HDDQ inhibited H2O2-induced phosphorylation of Akt by SIRT1 up-regulation and reduced SA-β-gal staining.

Conclusions:
HDDQ inhibits H2O2-induced premature senescence and upregulation of SIRT1 expression plays a vital role in the inhibition of the senescence phenotype in HDFs.
Borassus flabellifer L. crude male flower extracts alleviate cisplatin-induced oxidative stress in rat kidney cells
Authors: Tusskorn Ornanong , Pansuksan Kanoktip , Machana Kwanchayanawish 
Published: January 2021

Objective:
To investigate the effects of Borassus flabellifer L. extracts on antioxidant activity, maintenance of cellular redox, and mitochondrial function in cisplatin-induced kidney injury.

Methods:
The extracts of Borassus flabellifer were obtained from crude male flowers using ethyl acetate and methanol. The antioxidant potential was evaluated by 2,2-azino-bis-(3-ethylbenzothiazoline- 6-sulfonic acid), 2,2-diphenyl-1-picrylhydrazyl, and ferric reducing antioxidant power, and total phenolic content was also determined. Cytoprotective activity of ethyl acetate and methanolic extracts was assessed after kidney cells were treated with cisplatin. Oxidative stress was determined by glutathione (GSH) assay, and formation of reactive oxygen species (ROS) and changes in mitochondrial transmembrane potential (ΔΨm) using 2’,7’-dichlorofluorescin diacetate and JC-10 assays, respectively.

Results:

Borassus flabellifer methanolic extract exhibited greater antioxidant activity than the ethyl acetate extract. Cytoprotective effect was demonstrated in both extracts, particularly in the ethyl acetate extract. The extracts showed protection against the cytotoxic effect of cisplatin by prevention of the increased GSSG and declined GSH/GSSG ratio. Both extracts also prevented the increase in ROS formation, and loss of ΔΨm.

Conclusions:
Both Borassus flabellifer extracts show antioxidant activity and cytoprotective effect against cisplatin-induced cytotoxicity of NRK-52E cells by preventing oxidative stress and maintenance of GSH redox status. Borassus flabellifer extracts may possess beneficial effects on the prevention of oxidative stress- induced cell injury.
Breast cancer in young women: A
retrospective study from tertiary care center of
north India
Authors: Sharma Deepti , Singh Garima 
Published: January 2021

Abstract
Aim: Breast cancer is the most common
cause of cancer in women worldwide. They have more
aggressive clinical behaviour with poor outcomes
in younger patients. The aim of this study was to
evaluate the impact of age on prognosis of breast
cancer in women above and under 40 years of age.
Material and Methods: Medical record of 415
patients with invasive breast cancer were analysed
from January 2011 to December 2014 in our
department.The last was done in December 2015.All
cases diagnosed with breast cancer stages I to IV
were evaluated, and grouped on the basis of age
[less than 40 and above 40 years].Baseline
categorical variables were analysed using the
Chi-square test or Fisher's exact test. Non
categorical variable were analysed using t-test.
Result: A total of 372 patients were reviewed
because 42 patients defaulted. The median age at
the time of diagnosis was 44.6 years (range 23 to
90 years).Metastasis to distant organs were more
in women with age <40. Tumour relapse occurred
in 131 cases, among which 84 cases died, 35
patients (26.31%) in less than 40 group vs.49
patients (20.50%) in above 40 groups. The
estimated median OS in the two groups are 32 and
41 months respectively. Conclusion: The biological
behaviour of breast cancer in younger age group
has been shown to be associated with aggressive
nature and has a worse clinical outcome as
compared to that in older group.
Completeness of reporting and outcome switching in trials published in Indian journals from 2017 to 2019
Authors: Warrier Kiran , Jayanthi C. R. 
Published: January 2021

Context:
Randomized controlled trials (RCTs) are among the cornerstones for generation of high-quality clinical evidence. However, incomplete or biased reporting of trials can hamper the process of review of trials and their results. Outcome switching, intentional, or otherwise leads to biased reporting and can result in false inferences.

Aims:
The aim of this study was to analyze the completeness of reporting Consolidated Standards of Reporting Trials (CONSORT) 2010 checklist items and detect if outcome switching had occurred.

Settings and Design:
This cross-sectional study was conducted in the department of pharmacology.

Methods:
Online editions of journals published by the Indian association of medical specialties from 2017 to 2019 were accessed, and the full-text versions of the published RCTs in them were downloaded. Reporting of each item in the CONSORT checklist was recorded. The effect of trial registration and CONSORT endorsement on reporting of key methodological parameters was also determined. Protocols of registered trials were accessed, and the outcome switching was assessed.

Statistical Analysis Used:
Descriptive statistics were used to summarize the data.

Results:
Average completeness of reporting has significantly improved from 2017 to 2019. Major areas of underreporting were generalizability, protocol availability, trial registration, date of recruitment, allocation concealment, and the patient flow diagram. CONSORT endorsing journals had worse, whereas registered trials had better reporting of key methodological indicators. No overt switching of outcomes was observed in 84 out of 86 registered trials where trial protocols were available online for comparison.

Conclusions:
Quality of clinical trial reporting in the Indian medical journals has improved but remains inadequate. CONSORT nonendorsement prevents completeness of trial reporting.
Correlating the treatment outcome with
tumor staging, grading, and various treatment
modalities in patients with
esthesioneuroblastoma
Authors: Singh Shuchita , Singh Lavleen , Ranjan Richa , Singh Manoj Kumar , Thakar Alok , Sharma Suresh Chandra 
Published: January 2021

Abstract
Objective: Although till date no
management protocol for esthesioneuroblastoma
(ENB) has been standardized due to tumor rarity,
still multimodality approach shows better
treatment outcomes as compared to surgery alone.
The objective of this study was to analyze the
clinicopathological spectrum of ENB and to
correlate treatment response with tumor staging,
histopathological grading, and various treatment
modalities. Materials and Methods: Twenty-one
consecutive patients with biopsy-proven ENB were
studied and evaluated for response to treatment in
the form of complete tumor resolution. Results
were analyzed and correlated with stage and grade
of tumor and form of therapy received. Results:
There was male preponderance (3.2:1) with age
ranging between 7 and 63 years (median of 25
years). Survival rates significantly dropped with
increasing tumor stage (63.6% in stages A and B
vs. 30% in stages C and D) and grade (100% in
Grades 1 and 2 vs. 31.25% in Grades 3 and 4). The
recurrence rate was 80% in surgery alone group,
which came down to 43.7% if surgery was
supplemented with other modalities. In cases where
multimodality treatment plan was used, endoscopic
procedures fared equally as open surgical
procedures. Conclusion: Hyam’s grade and Kadish
stage are important prognostic indicators of
treatment outcome, with survival rates dropping
with increasing tumor stage and grade.
Multimodality treatment protocols have improved
the disease outcome, making endoscopic surgery
equivalent to radical surgeries regarding result
outcomes and giving other advantages such as
better cosmesis, less treatment-related
morbidities, decreased hospital stay, and better
cost-effectiveness.
First-line management of metastatic
non-small cell lung cancer: An Indian
perspective
Authors: Ghadyalpatil Nikhil Suresh , Pandey Avinash , Krishnamani Iyer , Srinivas Chilukuri , Rafiq Shabnam J. , Hingmire Sachin S. , Maturu Nagarjuna , Reddy Ragotham , Kumar Kiran K. , Sreekanth K. , Gurram Bharath Chandra , Parikh P. M. 
Published: January 2021

Abstract
Lung cancer has been the most common
cancer in the world for several decades. The
non-small cell lung cancer (NSCLC) constitutes
approximately about 80% of the total cases of lung
cancer. Therapeutic interventions in NSCLC have
shifted to the target-based approach from
histology-based approach, and this has completely
changed the face of the management of NSCLC.
Developing countries, such as India, have very
limited data compiled about the prevalence and
treatment practices of lung cancer, despite a
large burden of the disease. However, in recent
times, there has been a lot of data generated in
this regard. This article is an attempt to collate
and shine light on the available data for the
first-line treatment of NSCLC in India keeping in
mind the current standards of care in this
area.