bluuebunny/crossref_metadata_2025_split huggingface dataset:
Language and Its Limits: Meaning, Reference and the Ineffable in Buddhist Philosophy
Authors: Blomberg Johan , Żywiczyński Przemysław 
Published: July 2021

AbstractBuddhist schools of thought share two fundamental assumptions about language. On the one hand, language (śabda) is identified with conceptual thinking (kalpanā), which according to the Buddhist doctrine (dharma) separates us from the momentary and fleeting nature of reality (satya, “truth”). Language is comprised of generally applicable forms, which fuel the reificatory proclivity for clinging to the distorted – and ultimately fictious – belief in substantial existence. On the other hand, the distrust of language is mitigated by the doctrine of ineffability (anirdeśya), which although asserts that reality is beyond the scope of linguistic description, submits that philosophical analyses of key Buddhist concepts is a means of overcoming the limitations that language imposes on our experience and facilitating insight into the nature of reality (bodhi). This paper provides an overview of Buddhist philosophy of language, with an emphasis on the dialectical view of language as indispensable but ultimately insufficient for contemplation. The Buddhist discussions of ineffability are explicated and compared with its treatment in modern Occidental thought, specifically the similarities and differences with Wittgenstein’s philosophy of language.
Modelling land system evolution and dynamics of terrestrial carbon stocks in the Luanhe River Basin, China: a scenario analysis of trade-offs and synergies between sustainable development goals
Authors: Xu Jiren , Renaud Fabrice G. , Barrett Brian 
Published: July 2021

AbstractA more holistic understanding of land use and land cover (LULC) will help minimise trade-offs and maximise synergies, and lead to improved future land use management strategies for the attainment of Sustainable Development Goals (SDGs). However, current assessments of future LULC changes rarely focus on the multiple demands for goods and services, which are related to the synergies and trade-offs between SDGs and their targets. In this study, the land system (combinations of land cover and land use intensity) evolution trajectories of the Luanhe River Basin (LRB), China, and major challenges that the LRB may face in 2030, were explored by applying the CLUMondo and InVEST models. The results indicate that the LRB is likely to experience agricultural intensification and urban growth under all four scenarios that were explored. The cropland intensity and the urban growth rate were much higher under the historical trend (Trend) scenario compared to those with more planning interventions (Expansion,Sustainability, andConservationscenarios). Unless the forest area and biodiversity conservation targets are implemented (Conservationscenario), the forest areas are projected to decrease by 2030. The results indicate that water scarcity in the LRB is likely to increase under all scenarios, and the carbon storage will increase under theConservationscenario but decrease under all other scenarios by 2030. Our methodological framework and findings can guide regional sustainable development in the LRB and other large river basins in China, and will be valuable for policy and planning purposes to the pursuance of SDGs at the sub-national scale.
Gene editing in tree and clonal crops: progress and challenges
Authors: Goralogia Greg S. , Redick Thomas P. , Strauss Steven H. 
Published: July 2021

AbstractBecause of the limitations inherent in conventional breeding of trees and clonally propagated crops, gene editing is of great interest. Dozens of published papers attest to the high efficiency of CRISPR-based systems in clonal crops and trees. The opportunity for “clean” edits is expected to avoid or reduce regulatory burdens in many countries and may improve market acceptance. To date, however, nearly all studies in trees and clonal crops retained all of the gene editing machinery in the genome. Despite high gene editing efficiency, technical and regulatory obstacles are likely to greatly limit progress toward commercial use. Technical obstacles include difficult and slow transformation and regeneration, delayed onset of flowering or clonal systems that make sexual segregation of CRISPR-associated genes difficult, inefficient excision systems to enable removal of functional (protein- or RNA-encoding) transgenic DNA, and narrow host range or limited gene-payload viral systems for efficient transient editing. Regulatory obstacles include those such as in the EU where gene-edited plants are regulated like GMO crops, and the many forms of method-based systems that regulate stringently based on the method vs. product novelty and thus are largely applied to each insertion event. Other major obstacles include the provisions of the Cartagena Protocol with respect to international trade and the need for compliance with the National Environmental Policy Act in the USA. The USDA SECURE act has taken a major step toward a more science- and risk-based—vs. method and insertion event based—system, but much further regulatory and legal innovation is needed in the USA and beyond.
Acceleration-based disturbance compensation for elastic rack-and-pinion drives
Authors: Brenner Felix , Lechler Armin , Verl Alexander 
Published: July 2021

AbstractRack-and-pinion drives are mainly used for large machine tools and are often operated with indirect position control. Due to the lack of state information on the output side, this results in reduced accuracy regarding the table position. In addition, the system can only react inadequately to disturbances outside the control loop, meaning that often insufficient results can be achieved in typical application scenarios such as milling. To meet the increasing dynamic and accuracy requirements of the modern manufacturing industry, this paper presents a highly dynamic acceleration-based disturbance compensation method. For this purpose, the table acceleration is estimated using a dynamical model of the drive train and compared to the signal from an additional acceleration sensor attached to the machine table. Based on the resulting difference, an additional compensation torque is provided, which suppresses the disturbance in counterphase. The approach is tested experimentally on an open control platform with industrial drive components and the behavior is investigated based on compliance frequency responses and externally applied milling forces. At the same time, a standardized parametrization methodology is developed and the robustness is evaluated by varying table masses. In summary, a considerable improvement of the dynamic disturbance behavior can be achieved compared to the conventional system without compensator.
Maternal Ethanol Exposure Acutely Elevates Src Family Kinase Activity in the Fetal Cortex
Authors: Wang Dandan , Howell Brian W. , Olson Eric C. 
Published: July 2021

AbstractFetal alcohol syndrome (FAS) is characterized by disrupted fetal brain development and postnatal cognitive impairment. The targets of alcohol are diverse, and it is not clear whether there are common underlying molecular mechanisms producing these disruptions. Prior work established that acute ethanol exposure causes a transient increase in tyrosine phosphorylation of multiple proteins in cultured embryonic cortical cells. In this study, we show that a similar tyrosine phosphorylation transient occurs in the fetal brain after maternal dosing with ethanol. Using phospho-specific antibodies and immunohistochemistry, we mapped regions of highest tyrosine phosphorylation in the fetal cerebral cortex and found that areas of dendritic and axonal growth showed elevated tyrosine phosphorylation 10 min after maternal ethanol exposure. These were also areas of Src expression and Src family kinase (SFK) activation loop phosphorylation (pY416) expression. Importantly, maternal pretreatment with the SFK inhibitor dasatinib completely prevents both the pY416 increase and the tyrosine phosphorylation response. The phosphorylation response was observed in the perisomatic region and neurites of immature migrating and differentiating primary neurons. Importantly, the initial phosphotyrosine transient (~ 30 min) targets both Src and Dab1, two critical elements in Reelin signaling, a pathway required for normal cortical development. This initial phosphorylation response is followed by sustained reduction in Ser3 phosphorylation of n-cofilin, a critical actin severing protein and an identified downstream effector of Reelin signaling. This biochemical disruption is associated with sustained reduction of F-actin content and disrupted Golgi apparatus morphology in developing cortical neurons. The finding outlines a model in which the initial activation of SFKs by ethanol has the potential to disrupt multiple developmentally important signaling systems for several hours after maternal exposure.
Working towards full eradication of lipid-driven cardiovascular risk?
Authors: Nurmohamed N. S. , Stroes E. S. G. 
Published: July 2021

AbstractLipid-driven cardiovascular disease (CVD) risk is caused by atherogenic apolipoprotein B (apoB) particles containing low-density lipoprotein cholesterol (LDL-C), triglycerides and lipoprotein(a) [Lp(a)] and resembles a large and modifiable proportion of the total CVD risk. While a surplus of novel lipid-lowering therapies has been developed in recent years, management of lipid-driven CVD risk in the Netherlands remains suboptimal. To lower LDL‑C levels, statins, ezetimibe and proprotein convertase subtilisin/kexin type 9 inhibiting antibodies are the current standard of therapy. With the approval of bempedoic acid and the silencing RNA inclisiran, therapeutic options are expanding continuously. Although the use of triglyceride-lowering therapies remains a matter of debate, post hoc analyses consistently show a benefit in subsets of patients with high triglyceride or low high-density lipoprotein cholesterol levels. Pemafibrate and novel apoC-III could be efficacious options when approved for clinical use. Lp(a)-lowering therapies such as pelacarsen are under clinical investigation, offering a potent Lp(a)-lowering effect. If proven effective in reducing cardiovascular endpoints, Lp(a) lowering holds promise to be the third axis of effective lipid-lowering therapies. Using these three components of lipid-lowering treatment, the contribution of apoB-containing lipid particles to the CVD risk may be fully eradicated in the next decade.
Barriers to Sexual and Reproductive Wellbeing Among Saudi Women: a Qualitative Study
Authors: Alomair Noura , Alageel Samah , Davies Nathan , Bailey Julia V. 
Published: July 2021

Abstract
Introduction

In Saudi Arabia, sexual and reproductive health education is not offered in any formal setting, and there is a significant lack of knowledge amongst Saudi women. This study aimed to explore barriers to Saudi women’s sexual and reproductive wellbeing.

Methods
The study employed qualitative methods using semi-structured interviews with women in Riyadh, Saudi Arabia in 2019. The data were analysed using thematic analysis.

Results
Twenty-eight women were interviewed. Sexual and reproductive wellbeing is a complex matter affected by personal, familial, environmental, socio-cultural, religious, and institutional factors. Being unmarried is a significant barrier to accessing sexual and reproductive information and services, with ignorance signifying modesty and purity. Parental control acted as a barrier to acquiring knowledge and accessing essential healthcare services. Schools contribute to lack of awareness, with teachers omitting sexual and reproductive health-related subjects and evading answering questions.

Conclusions

There are multiple factors that restrict Saudi women’s access to sexual and reproductive health information and services, impacting their overall wellbeing. Research and policy efforts should be directed towards overcoming the complex barriers to Saudi women’s sexual and reproductive wellbeing. Public health initiatives are needed to improve youth, parents, and teacher’s knowledge, and improve public perceptions towards sexual and reproductive health education.
A Bayesian solution to the Behrens–Fisher problem
Authors: Girón Fco. Javier , del Castillo Carmen 
Published: July 2021

AbstractA simple solution to the Behrens–Fisher problem based on Bayes factors is presented, and its relation with the Behrens–Fisher distribution is explored. The construction of the Bayes factor is based on a simple hierarchical model, and has a closed form based on the densities of general Behrens–Fisher distributions. Simple asymptotic approximations of the Bayes factor, which are functions of the Kullback–Leibler divergence between normal distributions, are given, and it is also proved to be consistent. Some examples and comparisons are also presented.
Using Telehealth to Provide Interventions for Children with ASD: a Systematic Review
Authors: de Nocker Yanicka L. , Toolan Christina K. 
Published: July 2021

AbstractAs the need for accessible interventions for autism spectrum disorder (ASD) grows, empirically supported telehealth interventions become increasingly necessary. With the current COVID-19 public health crisis, in-person interventions have become largely infeasible; therefore, it is crucial that providers have information regarding the effectiveness of telehealth interventions. This systematic review evaluates and synthesizes existing group design research on telehealth ASD interventions. Sixteen articles were evaluated on implementer and child-level intervention outcomes as well as factors that promote equitable access to intervention. Findings suggest that telehealth programs are highly acceptable, comparable to face-to-face interventions, and can be an effective method of training implementers in interventions. Recommendations for future research and for maximizing equitable access to telehealth interventions are presented.
Thyroid surgery during the COVID-19 pandemic: results from a systematic review
Authors: Scappaticcio L. , Maiorino M. I. , Iorio S. , Camponovo C. , Piccardo A. , Bellastella G. , Docimo G. , Esposito K. , Trimboli P. 
Published: July 2021

Abstract
Purpose
During the COVID-19 pandemic, elective thyroid surgery is experiencing delays. The problem is that the COVID-19 pandemic is ongoing. The research purposes were to systematically collect the literature data on the characteristics of those thyroid operations performed and to assess the safety/risks associated with thyroid surgery during the COVID-19 pandemic.

Methods
We used all the procedures consistent with the PRISMA guidelines. A comprehensive literature in MEDLINE (PubMed) and Scopus was made using ‘‘Thyroid’’ and “coronavirus” as search terms.

Results
Of a total of 293 articles identified, 9 studies met the inclusion criteria. The total number of patients undergoing thyroid surgery was 2217. The indication for surgery was malignancy in 1347 cases (60.8%). Screening protocols varied depending on hospital protocol and maximum levels of personal protection equipment were adopted. The hospital length of stay was 2–3 days. Total thyroidectomy was chosen for 1557 patients (1557/1868, 83.4%), of which 596 procedures (596/1558, 38.3%) were combined with lymph node dissections. Cross-infections were registered in 14 cases (14/721, 1.9%), of which three (3/721, 0.4%) with severe pulmonary complications of COVID-19. 377 patients (377/1868, 20.2%) had complications after surgery, of which 285 (285/377, 75.6%) hypoparathyroidism and 71 (71/377, 18.8%) recurrent laryngeal nerve injury.

Conclusion
The risk of SARS-CoV-2 transmission after thyroid surgery is relatively low. Our study could promote the restart of planned thyroid surgery due to COVID-19. Future studies are warranted to obtain more solid data about the risk of complications after thyroid surgery during the COVID-19 era.
A mathematical approach to medical diagnosis via Pythagorean fuzzy soft TOPSIS, VIKOR and generalized aggregation operators
Authors: Naeem Khalid , Riaz Muhammad , Karaaslan Faruk 
Published: July 2021

AbstractHepatitis is a therapeutic disorder caused by the inflammation/infection of liver and regarded as the existence of cells causing inflammation in the tissues of body parts. Hepatitis is deliberated as a lethal disease worldwide, especially in developing countries mainly due to contaminated drinking water, unhygienic sanitary conditions and careless blood transfusion. This infection is basically considered as viral infection even though this sort of liver infection can also take place due to autoimmune, toxin, medications, unprotected physical relations, drugs and alcohol. Many approaches of identifying viral hepatitis have been sought so for, which include physical inspection, liver function tests (LFTs), liver surgery (biopsy), imaging studies such as sonogram or CT scan, ultrasound, blood tests, viral serology panel, DNA test, and viral antibody testing. In this article, we propose mathematical analysis of viral hepatitis types using Pythagorean fuzzy soft sets (PFSSs) via TOPSIS (Technique for Order of Preference by Similarity to Ideal Solution), VIKOR (Vise Kriterijumska Optimizacija Kompromisno Resenje) and generalized aggregation operators models and show that all the three techniques render the same optimal choice. We also present a commentary yielding comparison between the three techniques considering their structure of evaluation.
Impact of land use and land cover change on the magnitude of surface runoff in the endorheic Hayk Lake basin, Ethiopia
Authors: Mewded Mezgebu , Abebe Adane , Tilahun Seifu , Agide Zeleke 
Published: July 2021

AbstractThis study focused to analyze the main human-induced land use and/or cover changes and their impact on the response to surface runoff from the Hayk Lake endorheic basin between 1989 and 2015. The investigation of Landsat images of years 1989, 2000 and 2015 with the aid of ArcGIS 10.1 indicated an increase in cultivation land by 137.74% at the disbursement of a decrease of 1.34% in lake water, 49.48% in shrubland, 55.84% in plantation, and 17.32% in grassland. Overall accuracy (92%–96%) and kappa values (0.90–0.95) proved that the image classifications were accurate. The impact of the changed land use and/or cover on surface runoff was investigated by simulating the surface runoff for the years 1989, 2000 and 2015, and then quantifying the individual rate of contribution of land use and/or cover change on the magnitude of simulated surface runoff using HEC-HMS modeling tool. The analysis found that land use and cover change alone increased surface runoff by 20.18% and that climate change reduced surface runoff by 120.18%. The combined effect reduced surface runoff and caused a continued decline in water level at Hayk Lake. Therefore, this study advocated basin-based lake water management strategies linked to the negative impacts of land use and land cover, and climate change on the water balance of Hayk Lake for its sustainability.
Bias and comparison framework for abusive language datasets
Authors: Wich Maximilian , Eder Tobias , Al Kuwatly Hala , Groh Georg 
Published: July 2021

AbstractRecently, numerous datasets have been produced as research activities in the field of automatic detection of abusive language or hate speech have increased. A problem with this diversity is that they often differ, among other things, in context, platform, sampling process, collection strategy, and labeling schema. There have been surveys on these datasets, but they compare the datasets only superficially. Therefore, we developed a bias and comparison framework for abusive language datasets for their in-depth analysis and to provide a comparison of five English and six Arabic datasets. We make this framework available to researchers and data scientists who work with such datasets to be aware of the properties of the datasets and consider them in their work.
Are Radial Pressure Waves Effective in Treating Erectile Dysfunction? A Systematic Review of Preclinical and Clinical Studies
Authors: Sandoval-Salinas Carolina , Saffon José P. , Corredor Hector A. , Fonseca Liliana , Manrique Laura , Solis Giovani 
Published: July 2021

Abstract

Introduction
Radial waves are used to treat erectile dysfunction; however, they are different than focal waves, and their mechanism of action or effect on improving this condition is not known.

Aim
To evaluate the effect of radial waves at the cellular level and their effectiveness at the clinical level for the treatment of erectile dysfunction.

Methods
Systematic literature review. Electronic database searches and manual searches were performed to identify (i) clinical trials or cohort studies evaluating the effectiveness of radial waves in men with erectile dysfunction and (ii) preclinical trials in animal models or cell cultures in which the production of nitric oxide or endothelial growth factor was evaluated. Study quality was assessed, and data were extracted from each study. A narrative synthesis of the results was performed given the high heterogeneity between the selected studies.

Main outcomes measures
Nitric oxide production, endothelial growth factor expression, and changes in the Erection Hardness Score (EHS) and the International Index of Erectile Function (IIEF) Questionnaire score.

Results
Four studies in animal models and 1 randomized clinical trial in men with erectile dysfunction and kidney transplantation were identified that met the selection criteria. Preclinical studies in animals suggest that radial waves increase cellular apoptosis in penile tissue, while vascular endothelial growth factor expression increases in brain tissue. In men with erectile dysfunction, no differences were found between radial wave therapy and placebo therapy in the mean IIEF score (15.6 ± 6.1 vs 16.6 ± 5.4 at 1 month after treatment), EHS (2.5 ± 0.85 vs 2.4 ± 0.7 at 1 month after treatment), or penile Doppler parameters.

Conclusions
No quality evidence was found to support the use of radial waves in humans for the treatment of erectile dysfunction. In animal models and at the cellular level, the results are contradictory. More research is needed. Sandoval-Salinas C, Saffon JP, Corredor HA, et al. Are Radial Pressure Waves Effective in Treating Erectile Dysfunction? A Systematic Review of Preclinical and Clinical Studies. Sex Med 2021;9:100393.
Exploring city digital twins as policy tools: A task-based approach to generating synthetic data on urban mobility
Authors: Papyshev Gleb , Yarime Masaru 
Published: July 2021

AbstractThis article discusses the technology of city digital twins (CDTs) and its potential applications in the policymaking context. The article analyzes the history of the development of the concept of digital twins and how it is now being adopted on a city-scale. One of the most advanced projects in the field—Virtual Singapore—is discussed in detail to determine the scope of its potential domains of application and highlight challenges associated with it. Concerns related to data privacy, availability, and its applicability for predictive simulations are analyzed, and potential usage of synthetic data is proposed as a way to address these challenges. The authors argue that despite the abundance of urban data, the historical data are not always applicable for predictions about the events for which there does not exist any data, as well as discuss the potential privacy challenges of the usage of micro-level individual mobility data in CDTs. A task-based approach to urban mobility data generation is proposed in the last section of the article. This approach suggests that city authorities can establish services responsible for asking people to conduct certain activities in an urban environment in order to create data for possible policy interventions for which there does not exist useful historical data. This approach can help in addressing the challenges associated with the availability of data without raising privacy concerns, as the data generated through this approach will not represent any real individual in society.