bluuebunny/crossref_metadata_2025_split huggingface dataset:
Renewable Energy Deployment to Stimulate Energy Transition in the Gulf Cooperation Council
Authors: Bhatt Yagyavalk 
Published: February 2021

AbstractThe Gulf Cooperation Council (GCC) region plays a vital role in shaping the global energy markets because of its substantial amount of hydrocarbons resources. Although the GCC has abundant hydrocarbon resources, countries in the region have also shown their commitment and intent to become the global leaders in alternate energy, especially, renewable energy through their “Visions and Laws”. Further, All the countries in the Middle East have also set targets for the deployment of renewable energy at the federal or local level.For several decades, there has been steady economic and population growth of the Middle East countries, with most of the region’s wealth and socio-economic development, tied to its substantial oil and gas resources. Renewable energy can provide an alternative to their energy landscape, which holds a vast potential to cut fuel costs, reduce GHG emissions.To promote renewable energy, in the last five years, renewable energy has gained a lot of interest in the Gulf Cooperation Council (GCC) countries. Low tariffs bids for renewable energy generation in the United Arab Emirates (UAE) and Saudi Arabia since 2016 have made renewable energy, especially solar power competitive with conventional energy (International Renewable Energy Agency. Renewable Energy Market Analysis-GCC 2019. s.l.: International Renewable Energy Agency, 2019).With the push from the decision-makers to reduce the risk of dependence fossil fuels, the renewable energy plans can be implemented in the GCC. Decision-makers in the GCC have recognized the need for a plan for the post-oil era. This chapter will explore the GCC long term policies and government’s role in shaping the renewable energy market. Further, the chapter will also explore the challenges & opportunities related to the renewable energy sector in GCC (International Renewable Energy Agency. Renewable Energy Market Analysis-GCC 2019. s.l.: International Renewable Energy Agency, 2019).
Messung von schmerzbezogener Erlebensvermeidung: Analyse des Acceptance and Action Questionnaire-II-Pain bei Patienten mit chronischem Schmerz
Authors: Majeed Ronja , Faust Ira , Hüppe Michael , Hermann Christiane 
Published: February 2021

Zusammenfassung
Einleitung und Fragestellung
Erlebensvermeidung („experiential avoidance“) stellt einen zentralen störungsrelevanten Prozess im Rahmen der Akzeptanz- und Commitment-Therapie (ACT) dar. Zur Erfassung wurde der Acceptance and Action Questionnaire II (AAQ-II) entwickelt und in den Niederlanden für eine Patientengruppe mit chronischem Schmerz adaptiert und validiert (AAQ-II‑P). Hohe Werte im AAQ-II‑P bedeuten hohe schmerzbezogene Erlebensvermeidung. Ziel unserer Untersuchung ist die Erfassung von schmerzbezogener Erlebensvermeidung mit einer deutschen Version des AAQ-II‑P bei chronischen Schmerzpatienten und die Prüfung psychometrischer Merkmale des Messverfahrens.

Methodik
Der AAQ-II wurde mittels eines Vorwärts-Rückwärts-Verfahrens ins Deutsche übersetzt, für chronischen Schmerz adaptiert (AAQ-II‑P) und von 168 Patienten einer universitären Schmerzambulanz beantwortet. Zusätzlich wurden Daten zu schmerzbedingter Beeinträchtigung (CPG: Schweregrad nach von Korff) und Schmerzkatastrophisieren (PCS) erhoben sowie zu gesundheitsbezogener Lebensqualität (SF-12), Angst und Depressivität (HADS-D). Ebenfalls erfasst wurden allgemeine Persönlichkeitsmerkmale (BFI‑K) und habituelle Achtsamkeit (KIMS-S). Ausgewertet wurden Reliabilität und faktorielle Validität des AAQ-II‑P sowie seine Beziehung zu den anderen psychometrischen Verfahren.

Ergebnisse
Der AAQ-II‑P erzielte eine hohe interne Konsistenz mit α = 0,89 sowie eine eindimensionale Faktorenstruktur mit 61 % aufgeklärter Varianz. Geringe Korrelationen ergaben sich zu Persönlichkeitsdimensionen (maximal r = 0,44 zu Neurotizismus) und Achtsamkeit (maximal r = −0,43 zu Akzeptanz). Ein hoher Zusammenhang fand sich zu Schmerzkatastrophisieren (r = 0,75), Depression (r = 0,73) und Angst (r = 0,66). Die Beziehung zu Lebensqualität war am stärksten ausgeprägt auf der Psychischen Summenskala (r = −0,58).

Diskussion und Schlussfolgerung
Die deutsche Version des AAQ-II‑P hat eine gute Reliabilität und weist hinsichtlich Zuverlässigkeit und Faktorenstruktur hohe Vergleichbarkeit mit der Originalversion auf. Die Beziehungen zu den Skalen der psychometrischen Verfahren sind zumeist in erwarteter Richtung und Höhe. Patienten mit chronischem Schmerz und hoher schmerzbezogener Erlebensvermeidung tendieren deutlich zum Schmerzkatastrophisieren und zeichnen sich durch schlechtere psychische Lebensqualität aus. Dies spricht für die Relevanz des Konstrukts hinsichtlich therapeutischer Zielvariablen.
The impact of pandemics: revising the Spanish Flu in Italy in light of models’ predictions, and some lessons for the Covid-19 pandemic
Authors: Berbenni Enrico , Colombo Stefano 
Published: February 2021

AbstractWe consider some descriptive analysis of the main short- and medium-term economic indicators in Italy in the aftermath of the Spanish Flu pandemic. We analyse them in the light of the main neoclassical macroeconomic models of pandemics. Since most of the existing economic models about the consequences of a pandemic deal the pandemic event merely as a negative labour supply shock, we observe that some predictions of the theory about the economic impact of a pandemic seem not to be confirmed in the case of the Spanish Flu in Italy. In particular, economic indicators in Italy in the upsurge of the Spanish Flu need to be explained also in light of the consequences of the First World War. We use this evidence to discuss the predictions on the effects of the Covid-19 pandemic. We stress the importance of putting the analysis of the economic consequences of the current pandemic into the appropriate historical context.
Prediction of aircraft engine emissions using ADS-B flight data
Authors: Filippone A. , Parkes B. , Bojdo N. , Kelly T. 
Published: February 2021

ABSTRACTReal-time flight data from the Automatic Dependent Surveillance–Broadcast (ADS-B) has been integrated, through a data interface, with a flight performance computer program to predict aviation emissions at altitude. The ADS-B, along with data from Mode-S, are then used to ‘fly’ selected long-range aircraft models (Airbus A380-841, A330-343 and A350-900) and one turboprop (ATR72). Over 2,500 flight trajectories have been processed to demonstrate the integration between databases and software systems. Emissions are calculated for altitudes greater than 3,000 feet (609m) and exclude landing and take-off cycles. This proof of concept fills a gap in the aviation emissions inventories, since it uses real-time flights and produces estimates at a very granular level. It can be used to analyse emissions of gases such as carbon dioxide ($\mathrm{CO}_2$), carbon monoxide (CO), nitrogen oxides ($\mathrm{NO}_x$) and water vapour on a specific route (city pair), for a specific aircraft, for an entire fleet, or on a seasonal basis. It is shown how$\mathrm{NO}_x$and water vapour emissions concentrate around tropospheric altitudes only for long-range flights, and that the cruise range is the biggest discriminator in the absolute value of these and other exhaust emissions.
Trachytic Melt Inclusions Hosted in Clinopyroxene Offer a Glimpse Into Samoan EM2‐Endmember Melts
Authors: Adams J. V. , Spera F. J. , Jackson M. G. 
Published: February 2021

AbstractWe present major and trace element data on clinopyroxene‐hosted, glassy melt inclusions (MIs) from a highly enriched (high 87Sr/86Sr = 0.71856) lava (ALIA‐D115‐18) from the Samoan hot spot. Following correction for post‐entrapment crystallization, the MIs are trachytic (62.6–65.4 wt% SiO2, 1.5–3.0 wt% MgO, and 7.2–10.6 wt% total alkalis (Na2O + K2O)) ALIA‐D115 lavas dredged off the submarine flanks of Savai'i Island, western Samoa have previously been suggested to exhibit binary endmember magma mixing between a mafic, low 87Sr/86Sr magma and an evolved, high 87Sr/86Sr magma (the Enriched Mantle 2 endmember; EM2). In major and trace element space, these ALIA‐D115 lavas form a mixing trend between more primitive Samoan shield lavas and the MIs of this study, suggesting the MIs could represent the EM2‐derived mixing endmember. Recent efforts to constrain the EM2 mixing endmember composition shows remarkable overlap with the MI compositions, supporting the argument they could represent the 87Sr/86Sr mixing endmember to the ALIA‐D115 lavas and are derived from the EM2 endmember. Additionally, one melt inclusion contains Fo73 olivines not in equilibrium with the trachytic melt, suggesting the melt interacted with a mafic magma prior to entrapment within host clinopyroxene. Projecting the ALIA‐D115 mixing trend in 87Sr/86Sr versus SiO2 and K2O space shows that the trend intersects an average MI composition at 87Sr/86Sr values of ∼0.725, thereby offering a window into more extreme compositions associated with the EM2 endmember.
On the Initiation of Upward Negative Lightning by Nearby Lightning Activity: An Analytical Approach
Authors: Sunjerga Antonio , Rubinstein Marcos , Rachidi Farhad , Cooray Vernon 
Published: February 2021

AbstractUpward lightning occurs generally from tall structures. The mechanism of the initiation of upward lightning is not yet fully understood. Upward lightning can be classified into two categories based on either the absence or the presence of other lightning activity prior to the upward flash. This work proposes an explanation of how upward lightning flashes can be triggered by nearby lightning activity. It is generally thought that the lightning activity prior to the flash will intensify the electric field at the tip of the tall structures. However, to the best of our knowledge, no attempt has been made to evaluate theoretically this hypothesis. In this paper, we derive analytically the electric field enhancement on the ground (or at the top of tall structures) based on different triggering scenarios. These fields are later used in a simplified corona model to evaluate if they are able to trigger upward lightning. It is shown that both slow processes such as leader propagation and faster return strokes can trigger an upward negative flash from relatively short structures of a few tens of meters, even without any slowly varying background electric field. This study confirms theoretically experimental observations and it provides new insights into the mechanisms of initiation of upward flashes from tall structures.
Attaining Carnot efficiency with quantum and nanoscale heat engines
Authors: Bera Mohit Lal , Lewenstein Maciej , Bera Manabendra Nath 
Published: February 2021

AbstractA heat engine operating in the one-shot finite-size regime, where systems composed of a small number of quantum particles interact with hot and cold baths and are restricted to one-shot measurements, delivers fluctuating work. Further, engines with lesser fluctuation produce a lesser amount of deterministic work. Hence, the heat-to-work conversion efficiency stays well below the Carnot efficiency. Here we overcome this limitation and attain Carnot efficiency in the one-shot finite-size regime, where the engines allow the working systems to simultaneously interact with two baths via the semi-local thermal operations and reversibly operate in a one-step cycle. These engines are superior to the ones considered earlier in work extraction efficiency, and, even, are capable of converting heat into work by exclusively utilizing inter-system correlations. We formulate a resource theory for quantum heat engines to prove the results.
DNA methylation status correlates with adult β-cell regeneration capacity
Authors: Khurana Ishant , Al-Hasani Keith , Maxwell Scott , K.N. Harikrishnan , Okabe Jun , Cooper Mark E. , Collombat Patrick , El-Osta Assam 
Published: February 2021

AbstractThe role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in β-cell regeneration in adulthood, a well described pathophysiological phenomenon of major significance in explaining β-cell deficiency in diabetes in the adult pancreas.
Diagnosis of coronary artery spasm by ergonovine provocation test of radial artery
Authors: Li Ye-fei , Zhang Yu , Chen Liang , Zheng Kou-long , Lu Hui-he , Sheng Zhen-qiang 
Published: February 2021

AbstractWe investigated the sensitivity, specificity and safety of ergonovine provocation test of radial artery in the diagnosis of coronary artery spasm (CAS). The patients who came to our hospital for chest pain from January to June 2020 as well as had coronary stenosis < 50% and no radial artery stenosis, were enrolled in this study. These patients were divided into CAS group and control group after intracoronary ergonovine provocation test. All patients underwent ergonovine provocation test of radial artery, the inner diameter (D0 and D1) and the peak systolic velocities (PSV0 and PSV1) of the radial artery were measured by ultrasound before and after ergonovine provocation. The predictive value of ergonovine provocation test of radial artery for the diagnosis of CAS was analyzed using receiver operator characteristic (ROC) curve. There were 19 patients in the CAS group and 28 patients in the control group. Low density lipoprotein cholesterol and smoking rate were significantly higher in the CAS group than in the control group (all P < 0.05), but there were no significant differences in other items (P > 0.05) between the two groups. In the ergonovine provocation test of radial artery, degree of radial artery stenosis was significantly higher in the CAS group [41.50% (35.60%, 50.00%)] than in the control group [11.25% (5.15%, 23.00%)] (P = 0.000), but there were no siginificant differences in D0, PSV0 and PSV1 between the two groups (P > 0.05). The area under ROC curve of ergonovine (120 µg) provocation test of radial artery for the diagnosis of CAS was 0.912 with 95%CI: 0.792–0.975, P = 0.001, cut-off of 31%, specificity of 92.86% and sensitivity of 84.21%. The ergonovine (120 µg) provocation test of radial artery did not cause any adverse reactions. We concluded that the ergonovine provocation test of radial artery has high sensitivity, specificity and safety in the diagnosis of CAS.
PD-L1 immunohistochemistry for canine cancers and clinical benefit of anti-PD-L1 antibody in dogs with pulmonary metastatic oral malignant melanoma
Authors: Maekawa Naoya , Konnai Satoru , Nishimura Maki , Kagawa Yumiko , Takagi Satoshi , Hosoya Kenji , Ohta Hiroshi , Kim Sangho , Okagawa Tomohiro , Izumi Yusuke , Deguchi Tatsuya , Kato Yukinari , Yamamoto Satoshi , Yamamoto Keiichi , Toda Mikihiro , Nakajima Chie , Suzuki Yasuhiko , Murata Shiro , Ohashi Kazuhiko 
Published: February 2021

AbstractImmunotherapy targeting programmed cell death 1 (PD-1) and PD-ligand 1 (PD-L1) represents promising treatments for human cancers. Our previous studies demonstrated PD-L1 overexpression in some canine cancers, and suggested the therapeutic potential of a canine chimeric anti-PD-L1 monoclonal antibody (c4G12). However, such evidence is scarce, limiting the clinical application in dogs. In the present report, canine PD-L1 expression was assessed in various cancer types, using a new anti-PD-L1 mAb, 6C11-3A11, and the safety and efficacy of c4G12 were explored in 29 dogs with pulmonary metastatic oral malignant melanoma (OMM). PD-L1 expression was detected in most canine malignant cancers including OMM, and survival was significantly longer in the c4G12 treatment group (median 143 days) when compared to a historical control group (n = 15, median 54 days). In dogs with measurable disease (n = 13), one dog (7.7%) experienced a complete response. Treatment-related adverse events of any grade were observed in 15 dogs (51.7%). Here we show that PD-L1 is a promising target for cancer immunotherapy in dogs, and dogs could be a useful large animal model for human cancer research.
Development of an online research platform for use in a large-scale multicentre study
Authors: Godden A R , Micha A , Pitches C , Barry P A , Krupa K D C , Rusby J E 
Published: February 2021

Abstract

Background
Participation in research can be beneficial for patients and healthcare providers, but may prove demanding at patient, clinician and organizational levels. Patient representatives are supportive of online research to overcome these challenges. The aim of this pilot study was to develop an online recruitment platform and test its feasibility and acceptability while evaluating the accuracy of participant-reported data.

Methods
The online research platform was developed in a 1-day ‘hackathon’ with a digital design company. Women who underwent implant-based breast reconstruction in 2011–2016 were invited by letter containing the web address (URL) of the study site and their unique study number. Once online, participants learned about the study, consented, entered data on demographics, treatment received and patient-reported outcome measures (BREAST-Q™), and booked an appointment for a single hospital visit for three-dimensional surface imaging (3D-SI). Real-time process evaluation was performed. The primary endpoint was recruitment rate.

Results
The recruitment rate was 40 per cent. Of the 100 women, 50 logged on to the platform and 40 completed the process through to 3D-SI. The majority of discontinuations after logging on occurred between consenting and entering demographics (3 women, 6 per cent), and between completing the BREAST-Q and booking an appointment for 3D-SI using the online calendar (3 women, 6 per cent). All women completed the online BREAST-Q™ once started. Participants took a median of 23 minutes to complete the online process. Patient-reported clinical data were accurate in 12 of 13 domains compared with electronic records (95 per cent concordance). Process evaluation demonstrated acceptability.

Conclusion
The results of this pilot demonstrate the online platform to be acceptable, feasible, and accurate for this population from a single institution. The low-burden design may enable participation from centres with less research support and participants from hard-to-reach groups or dispersed geographical locations, but with online access.
Cardiovascular biomarkers in patients with COVID-19
Authors: Mueller Christian , Giannitsis Evangelos , Jaffe Allan S , Huber Kurt , Mair Johannes , Cullen Louise , Hammarsten Ola , Mills Nicholas L , Möckel Martin , Krychtiuk Konstantin , Thygesen Kristian , Lindahl Bertil ,   ESC Study Group on Biomarkers in Cardiology of the Acute Cardiovascular Care Association
Published: February 2021

Abstract
The coronavirus disease 2019 (COVID-19) pandemic has increased awareness that severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2) may have profound effects on the cardiovascular system. COVID-19 often affects patients with pre-existing cardiac disease, and may trigger acute respiratory distress syndrome (ARDS), venous thromboembolism (VTE), acute myocardial infarction (AMI), and acute heart failure (AHF). However, as COVID-19 is primarily a respiratory infectious disease, there remain substantial uncertainty and controversy whether and how cardiovascular biomarkers should be used in patients with suspected COVID-19. To help clinicians understand the possible value as well as the most appropriate interpretation of cardiovascular biomarkers in COVID-19, it is important to highlight that recent findings regarding the prognostic role of cardiovascular biomarkers in patients hospitalized with COVID-19 are similar to those obtained in studies for pneumonia and ARDS in general. Cardiovascular biomarkers reflecting pathophysiological processes involved in COVID-19/pneumonia and its complications have a role evaluating disease severity, cardiac involvement, and risk of death in COVID-19 as well as in pneumonias caused by other pathogens. First, cardiomyocyte injury, as quantified by cardiac troponin concentrations, and haemodynamic cardiac stress, as quantified by natriuretic peptide concentrations, may occur in COVID-19 as in other pneumonias. The level of those biomarkers correlates with disease severity and mortality. Interpretation of cardiac troponin and natriuretic peptide concentrations as quantitative variables may aid in risk stratification in COVID-19/pneumonia and also will ensure that these biomarkers maintain high diagnostic accuracy for AMI and AHF. Second, activated coagulation as quantified by D-dimers seems more prominent in COVID-19 as in other pneumonias. Due to the central role of endothelitis and VTE in COVID-19, serial measurements of D-dimers may help physicians in the selection of patients for VTE imaging and the intensification of the level of anticoagulation from prophylactic to slightly higher or even therapeutic doses.
Aspiration Thrombectomy: 2-Dimensional Operative Video
Authors: Turner Raymond , Turk Aquilla , Chaudry Imran , Vargas Jan ,   Endovascular Neurosurgery Research Group, Arthur Adam , Bain Mark , Bendock Bernard , Binning Mandy Jo , Boulos Alan S , Crowley Webster , Fessler Richard , Grande Andrew , Guterman Lee , Hanel Ricardo , Hoit Daniel , Hopkins L Nelson , Howington Jay , James Robert , Jankowitz Brian , Kan Peter , Khalessi Alex A , Kim Louis , Langer David , Lanzino Giuseppe , Levitt Michael , Levy Elad , Lopes Demetrius , Mack William , Mericle Robert , Mocco J , Ogilvy Chris , Pandey Aditya , Replogle Robert , Riina Howard , Ringer Andrew , Rodriguez Rafael , Saugaveau Eric , Schirmer Clemens , Siddiqui Adnan , Spiotta Alex , Sultan Ali , Tawk Rabih , Thomas Ajith , Turner Raymond , Veznedaroglu Erol , Welch Babu , White Jonathan 
Published: February 2021

Abstract
Acute ischemic stroke is one of the leading causes of disability and mortality worldwide. There have been significant improvements to the treatment of acute ischemic stroke over the past 5 yr, specifically related to strokes caused by large vessel occlusions. Stent retrievers with and without local aspiration and direct aspiration alone have all been demonstrated as viable treatment options for this patient population. This case represents the surgical technique for direct aspiration for the treatment of large vessel occlusion.
A 76-yr-old man presented with right-sided weakness and aphasia. His last known normal was 5 h ago. His NIHSS (National Institutes of Health Stroke Scale) was 18. The noncontrast computed tomography (CT) did not show a significant infarct burden and ASPECTS (Alberta Stroke Program Early CT Score) of 9. CT angiogram demonstrated a left M1 occlusion. The patient was not a candidate for tissue plasminogen activator (tPA) because of time to presentation; however, the patient was deemed to be a candidate for emergent thrombectomy. Consent was obtained per institutional guidelines for the emergent procedure and the video recording. The video demonstrates a direct aspiration thrombectomy technique for the treatment of stroke.
The patient successfully underwent direct aspiration thrombectomy with a TICI 3 (thrombolysis in cerebral infarction) recanalization.