bluuebunny/crossref_metadata_2025_split huggingface dataset:
Secondary stone formation 8 weeks after percutaneous nephrolithotomy treatment
Authors: Deng Qiong , Wang Hongliang , Lai Yulin , Liang Hui 
Published: May 2021

Abstract

Introduction:
This work reports a patient with recurrent renal calculi subjected to three surgeries in half a year to be in the same position, and the high-throughput sequencing data showed different species in the renal pus and urine samples, which suggested that partial renal infection or stone formation can be judged by the bacteria in urine.

Patient concerns:
The female patient aged 43 years was referred to the authors’ department on April 13, 2020, due to left waist pain and fever for 3 days.

Diagnosis:
Kidney stones and hydronephrosis were determined by a urinary system computed tomography scan.

Interventions:
On April 20, 2020 and June 15, 2020, the patient was successfully treated with left percutaneous nephrolithotomy twice under general anesthesia. An investigation on the health and eating habits of the patient within 6 months was completed at the last admission. The components of the second renal calculus sample were analyzed with an infrared spectrum analyzer. The third renal stone (renal pus, triplicates) was subjected to microbial metagenome sequencing, and urine samples before and after surgery were subjected to 16S RNA sequencing by SEQHEALTH (Wuhan, China).

Outcomes:
After percutaneous nephrolithotomy, the left kidney stones were basically cleared, stone analysis revealed that the main components were calcium oxalate monohydrate, silica, and a small amount of calcium oxalate dehydrate. Although the urine samples exhibited differences, the renal pus and urine sample shared a single species.

Conclusion:
It is not clear that the prospects of partial renal infection or stone formation can be judged by the bacteria in urine.
The important role of MDM2, RPL5, and TP53 in mycophenolic acid-induced cleft lip and palate
Authors: Lin Yangyang , Song Tao , Ronde Elsa M. , Ma Gang , Cui Huiqin , Xu Meng 
Published: May 2021

Abstract
Mycophenolate embryopathy (MPE) is a mycophenolic acid (MPA)-induced congenital malformation with distinctive symptoms. Cleft lip/palate (CLP) is one of the most common symptoms of MPE. The aim of this study was to screen and verify hub genes involved in MPA-induced CLP and to explore the potential molecular mechanisms underlying MPE.
Overlapping genes related to MPA and CLP were obtained from the GeneCards database. These genes were further analyzed via bioinformatics. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis results were visualized with the Cytoscape ClueGO plug-in. Gene protein-protein interaction (PPI) networks were constructed based on data obtained from the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database.
Overall, 58 genes related to MPA and CLP were identified. The genes most relevant to MPA-induced CLP included ABCB1, COL1A1, Rac1, TGFβ1, EDN1, and TP53, as well as the TP53-associated genes MDM2 and RPL5. GO analysis demonstrated gene enrichment regarding such terms as ear, mesenchymal, striated muscle, and ureteric development. KEGG analysis demonstrated gene enrichment in such pathways as the HIF-1 signaling pathway, glycosylphosphatidylinositol-anchor biosynthesis, the TNF signaling pathway, and hematopoietic stem cell development.
Bioinformatic analysis was performed on the genes currently known to be associated with MPA-induced CLP pathogenesis. MPA-induced CLP is mediated by multiple ribosome stress related genes and pathways. MDM2, RPL5 and TP53 could be the main contributor in this pathogenesis, along with several other genes. ABCB1 polymorphism could be related to the probability of MPA-induced CLP.
Feasibility of a patient engagement and medication safety management program for older adults suffering cardiovascular disease in community settings
Authors: Wang Wenna , Zhang Huiling , Lin Beilei , Zhang Zhenxiang 
Published: May 2021

Abstract

Objectives:
To assess the feasibility of a patient engagement and medication safety management (PE-MSM) program on medication errors, self-efficacy for appropriate medication and activation among older patients suffering cardiovascular disease (CVD) in Chinese communities.

Methods:
A patient engagement and medication safety management (PE-MSM) program intervention study was performed. Older patients suffering CVD in the intervention group (n = 62) received PE-MSM program, while the control group (n = 58) took a 12-week medication safety education alone.

Results:
Compared with the control group, patients having undergone the individualized PE-MSM program achieved lower incidence of medication errors (P < .001), and a statistically significant interaction was identified between treatment groups and assessment time points in terms of the total score of self-efficacy for appropriate medication use scale and the number of patients with different activation levels (P < .001).

Conclusions:
The PE-MSM program is demonstrated to be feasible. Compared with single medication safety education, the PE-MSM program is capable of decreasing the incidence of common medication errors, enhancing the self-efficacy of appropriate medication and the activation of older patients with CVD in a community.

Practice implications:
The PE-MSM program is likely to act as a promising medication management model for the routine health care of older patients suffering CVD in communities.
CHA2DS2-VASc score predicts the slow flow/no-reflow phenomenon in ST-segment elevation myocardial infarction patients with multivessel disease undergoing primary percutaneous coronary intervention
Authors: Huang Xin , Zheng Wen , Zhao Xue Dong , Nie Shao Ping 
Published: May 2021

Abstract
ST-segment elevation myocardial infarction (STEMI) patients with multivessel disease (MVD) have a higher incidence of slow-flow/no-reflow (SF-NR) phenomenon during primary percutaneous coronary intervention (PPCI) than those with single vessel disease. Currently, no effective tools exist to predict the risk of SF-NR in this population. The present study aimed to evaluate whether CHA2DS2-VASc score can be used as a simple tool to predict this risk.
This study consecutively included STEMI patients hospitalized in Beijing Anzhen Hospital from January 2005 to January 2015. Among these patients, 1032 patients with MVD were finally enrolled. Patients were divided into SF-NR (+) group and SF-NR (–) group according to whether SF-NR occurred during PPCI. SF-NR was defined as the thrombolysis in myocardial infarction (TIMI) grade ≤2.
There were 134 patients (13%) in the SF-NR (+) group. Compared with the SF-NR (–) group, patients in the SF-NR (+) group are elder, with lower left ventricular ejection fraction and higher CHA2DS2-VASc score. Multiple logistic regression analysis indicated that CHA2DS2-VASc score ≥3 (odds ratio [OR], 2.148; 95% confidence interval [CI], 1.389–3.320; P = .001), current smoking (OR, 1.814; 95% CI, 1.19–2.764; P = .006), atrial fibrillation (OR, 2.892; 95% CI, 1.138–7.350; P = .03), complete revascularization (OR, 2.307; 95% CI, 1.202–4.429; P = .01), and total length of stents ≥40 mm (OR, 1.482; 95% CI, 1.011–2.172; P = .04) were independent risk factors of SF-NR. The incidence of SF-NR in patients with CHA2DS2-VASc score ≥3 was 1.7 times higher than that in patients with CHA2DS2-VASc score <3. Additionally, patients with CHA2DS2-VASc score ≥3 plus ≥2 risk factors have 3 times higher incidence of SF-NR than those with CHA2DS2-VASc score ≥3 plus 0 to 1 risk factor.
CHA2DS2-VASc score ≥3 can be used as a simple and sensitive indicator to predict SF-NR phenomenon and guide the PPCI strategy in STEMI patients with MVD.
Stent insertion for inoperable hilar cholangiocarcinoma
Authors: Lin Jia , Wu An-Le , Teng Fei , Xian Yu-Tao , Xu Xin-Jian 
Published: May 2021

Abstract
To assess effectiveness and safety associated with radioactive stenting for hilar cholangiocarcinoma (HCCA) patients.
This single-center retrospective study compared baseline and treatment data of recruited consecutive patients with HCCA underwent either normal or radioactive stenting between January 2016 and December 2019. Clinical success was defined by total bilirubin (TBIL) levels falling below 70% of the preoperative baseline within 2 weeks post stent insertion.
Sixty-five patients with inoperable HCCA underwent normal (n = 35) or radioactive (n = 30) stenting at our center. Technical success of both types of the normal and radioactive stent insertion was 100%. Each patient received 1 stent. In the radioactive stent group, each patient received 1 radioactive seed strand (RSS), containing 10 to 12 radioactive seeds. Clinical success rates were 86.8% and 100% in normal and radioactive groups, respectively (P = .495). We observed stent dysfunction in 9 patients (normal group) and 7 patients (radioactive group) (P = .824). Median duration of stent patency was 165 days (normal group) and 226 days (radioactive group) (P < .001). During follow-up, all patients died from tumor progression, with respective median survival of 198 days (normal group) and 256 days (radioactive group) (P < .001). Seven and 5 patients in the normal and radioactive groups suffered from stent-related complications (P = .730).
Radioactive stenting is effective and safe for inoperable HCCA patient and may prolong stent patency and survival.
Incidence and risk factors for 30-day readmission in ulcerative colitis: nationwide analysis in biologic era
Authors: Vohra Ishaan , Attar Bashar , Haghbin Hossein , Mutneja Hemant , Katiyar Vatsala , Sharma Sachit , Abegunde Ayokunle T. , Demetria Melchor , Gandhi Seema 
Published: May 2021

Background and study aim
Ulcerative colitis (UC) is a chronic relapsing and remitting disease requiring frequent hospitalization. Biologics have become the recommended initial therapy for Biologics in patients with moderate to severe UC. Our aim was to estimate the changes in Nationwide Healthcare utilization and assess predictive factors of 30-day readmission, morbidity and mortality of UC.

Methods
This is a retrospective observational study analyzing the Nationwide Readmission database from 2016 to 2017 using ICD-10 codes. The primary outcomes of the study were to assess the predictors of 30-day readmission in patients with UC.

Results
Of the 54 138 adult patients with a primary diagnosis of UC, 13.2% were readmitted within 30 days of index hospitalization. The mortality rate (1.4 vs. 0.3%, P < 0.01), length of stay (7 vs. 4.9 days, P < 0.01) and hospital cost ($62 552 vs. $46 971, P < 0.01) were higher on readmission as compared to index hospitalization. We identified multiple patient-related factors (age <65years, men, VTE, protein calorie malnutrition, electrolyte imbalance, anemia, anxiety and alcohol abuse), hospital-related factors (teaching hospitals, high quintile hospitals), as independent predictors of 30-day UC readmission. Colonoscopy, Cannabis use, and colectomy were associated with decreased odds of 30-day readmission. The most common cause of UC was septicemia.

Conclusions
This is the largest nationwide study demonstrating predictors of 30-day readmission, mortality and morbidity associated with UC. Identification and amelioration of these risk factors will decrease readmission rate and mortality amongst UC patients.
Mucosal defect size predicts the adequacy of resection of ≤10 mm nonpedunculated colorectal polyps using a new cold snare polypectomy technique
Authors: Kudo Takahiro , Horiuchi Akira , Kyodo Reiko , Tokita Kazuhide , Tanaka Naoki , Horiuchi Ichitaro , Sano Kenji 
Published: May 2021

Objectives
There is still room for improvement in the methods used to achieve complete polyp resection. The aim of this study was to develop a cold snare polypectomy technique that will reliably result in resections containing the muscularis mucosae and the lateral polyp margins.

Materials and methods
Nonpedunculated polyps ≤10 mm were resected using a dedicated cold snare with the goal of creating a mucosal defect approximately 1 cm in dia. The completeness of resection of the lateral and vertical polyp margins was examined histologically.

Results
The cases of 201 patients (mean age 67 ± 13 years; 115 men) with 500 eligible polyps were enrolled. The mean polyp size was 6.1 ± 1.8 mm (range 1–10 mm). The mean mucosal defect size immediately after resection was 7.7 ± 2.5 mm (range 3–15 mm). Overall, the complete resection rate in which the lateral and vertical margins were free from the neoplasia tissue was 92% (417/454, 95% CI, 89–94); in the remaining 8% of cases, the vertical margins showed complete resection but the lateral margins could not be evaluated due to the fragmentation of resected polyps. A mucosal defect ≥7 mm predicted complete resection of the mucosal layer containing the muscularis mucosae.

Conclusion
Complete mucosal layer resection of nonpedunculated colorectal polyps ≤10 mm was reliably achieved using a cold snare technique that produced a mucosal defect ≥7 mm in dia.
Subacute Cerebral Infarction With Accumulation of 99mTc-TRODAT in the Parkinson Disease Patient
Authors: Kao Chun-Hao , Chiu Chuang-Hsin 
Published: May 2021

Abstract
We report the accumulation of 99mTc-TRODAT-1 in the region of subacute cerebral ischemic infarction in an 81-year-old woman with Parkinson disease. The dopamine transporter SPECT imaging was performed on the 15th day after the onset of acute cerebral ischemic clinical symptoms. Overexpression of dopamine transporters after infarction in subacute phase may explain the accumulation.
Primary Adenosquamous Carcinoma of the Liver on FDG PET/CT
Authors: Filizoglu Nuh , Oksuzoglu Kevser , Ozguven Salih 
Published: May 2021

Abstract
Primary adenosquamous carcinoma (ASC) of the liver is a rare subtype of intrahepatic cholangiocarcinoma. Hepatic ASC consists of both adenocarcinoma and squamous cell carcinoma components. Because hepatic ASC is extremely rare, only a few cases describing the imaging findings of hepatic ASC were reported before. Herein, we present FDG PET/CT findings of hepatic ASC in a 78-year-old woman who was admitted to hospital with a 4-week history of right upper quadrant pain.
FDG PET/CT in Tenosynovial Giant Cell Tumor of the Lumbar Facet Joint
Authors: Zhang Jian , Li Yuhan , Zhu Yanfang , Duan Ying , Zhu Yuzhao 
Published: May 2021

Abstract
Tenosynovial giant cell tumor rarely affects the facet joints of the spine. We describe FDG PET/CT findings in a case of tenosynovial giant cell tumor arising from the left L2 to L3 facet joint. The tumor caused osteolytic bone destruction of the facet joint and showed intense FDG uptake with SUVmax of 10.4. This case indicates tenosynovial giant cell tumor should be included in the differential diagnosis of abnormal facet joint FDG accumulation.
Diffuse Large B-cell Lymphoma
Authors: Sakurada Hiroki , Koyasu Sho , Sugimoto Akihiko , Nakanishi Etsuro , Nakamoto Yuji 
Published: May 2021

Abstract
A 77-year-old man with parkinsonism was referred to the department of neurology for further examination. Cardiac 123I-MIBG scintigraphy unexpectedly showed strong uptake in the left shoulder, suggestive of MIBG-avid tumors including paraganglioma. MRI revealed multiple nodules suggestive of lymphoma. A biopsy was performed, which led to the pathological diagnosis of diffuse large B-cell lymphoma. Cardiac MIBG scintigraphy sometimes shows unexpected findings outside the mediastinum. In addition, lymphoma should also be added to the list of differential diagnoses for MIBG-positive tumors.
Selective Prehospital Advanced Resuscitative Care – Developing a Strategy to Prevent Prehospital Deaths From Noncompressible Torso Hemorrhage
Authors: Qasim Zaffer , Butler Frank K. , Holcomb John B. , Kotora Joseph G. , Eastridge Brian J. , Brohi Karim , Scalea Thomas M. , Schwab C. William , Drew Brendon , Gurney Jennifer , Jansen Jan O. , Kaplan Lewis J. , Martin Matthew J. , Rasmussen Todd E. , Shackelford Stacy A. , Bank Eric A. , Braude Darren , Brenner Megan , Guyette Francis X. , Joseph Bellal , Hinckley William R. , Sperry Jason L. , Duchesne Juan 
Published: May 2021

ABSTRACT
Hemorrhage, and particularly noncompressible torso hemorrhage remains a leading cause of potentially preventable prehospital death from trauma in the United States and globally. A subset of severely injured patients either die in the field or develop irreversible hemorrhagic shock before they can receive hospital definitive care, resulting in poor outcomes. The focus of this opinion paper is to delineate
Surveillance of colistin-resistance andmcr genes inmulti-drug resistant Enterobacteriaceae
Authors: Kawamoto Yasuhide , Kaku Norihito , Akamatsu Norihiko , Sakamoto Kei , Kosai Kosuke , Morinaga Yoshitomo , Ohmagari Norio , Izumikawa Koichi , Yamamoto Yoshihiro , Mikamo Hiroshige , Kaku Mitsuo , Oishi Kazunori , Yanagihara Katsunori 
Published: May 2021

AbstractBackgroundThe plasmid-mediated bacterial colistin-resistant (mcr) gene is a global concern in clinical health care. This study aimed to clarify the prevalence of colistin resistance through ninemcrgenes in ESBL-producing and CRE isolated Enterobacteriaceae in Japan.MethodsWe collected strains from August 2016 to March 2017 from five tertiary hospitals. MICs were measured using the microdilution method. PCR was performed to detectmcr-1tomcr-9genes in all strains. Additionally, we performed whole-genome sequencing of themcrgene-positive strain.ResultsThe rate of colistin resistance was 7.7%. Themcr-5andmcr-9gene were detected in one ESBL-producingE. colistrain (0.37%) and three CRE strains (1.1%), respectively. Since the ESBL-producingE. colistrain was the first clinical strain withmcr-5in Japan, whole-genome sequencing analysis was performed for the strain. The sequenece type of themcr-5positive strain was ST1642 and it carried two distinct plasmids, ESBL gene-carrying pN-ES-6-1 andmcr-5.1-carrying pN-ES-6-2.ConclusionsWe showed that the frequency of colistin resistance andmcr-positive strains is not high in Japan. Since the MIC for colistin was low in themcr-5.1andmcr-9gene-positive strain, continuous monitoring ofmcrgenes is necessary.
Association of Intravenous Bamlanivimab Use with Reduced Hospitalization, Intensive Care Unit Admission, and Mortality in Patients with Mild to Moderate COVID-19
Authors: Ganesh Ravindra , Pawlowski Colin , O’Horo John C. , Arndt Lori L. , Arndt Richard , Bell Sarah J. , Bierle Dennis M. , Borgen Molly Destro , Hanson Sara N. , Heyliger Alexander , Larsen Jennifer J. , Lenehan Patrick , Orenstein Robert , Puranik Arjun , Speicher Leigh L. , Tulledge-Scheitel Sidna M. , Venkatakrishnan AJ , Wilker Caroline G. , Badley Andrew D. , Razonable Raymund R. 
Published: May 2021

AbstractBackgroundClinical data to support the use of bamlanivimab for the treatment of outpatients with mild to moderate coronavirus disease-19 (COVID-19) is needed.Methods2,335 patients who received single-dose bamlanivimab infusion between November 12, 2020 to February 17, 2021 were compared with a propensity-matched control of 2,335 untreated patients with mild to moderate COVID-19 at Mayo Clinic facilities across 4 states. The primary outcome was the rate of hospitalization at days 14, 21 and 28.ResultsThe median age of the population was 63; 47.3% of the bamlanivimab-treated cohort were ≥65 years; 49.3% were female. High-risk characteristics included hypertension (54.2%), body mass index ≥35 (32.4%), diabetes mellitus (26.5%), chronic lung disease (25.1%), malignancy (16.6%), and renal disease (14.5%). Patients who received bamlanivimab had lower all-cause hospitalization rates at days 14 (1.5% vs 3.5%; Odds Ratio [OR], 0.38), 21 (1.9% vs 3.9%; OR, 0.46), and 28 (2.5% vs 3.9%; OR, 0.61). Secondary exploratory outcomes included lower intensive care unit admission rates at days 14 (0.14% vs 1%; OR, 0.12), 21 (0.25% vs 1%; OR: 0.24) and 28 (0.56% vs 1.1%; OR: 0.52), and lower all-cause mortality at days 14 (0% vs 0.33%), 21 (0.05% vs 0.4%; OR,0.08) and 28 (0.11% vs 0.44%; OR, 0.01). Adverse events were uncommon with bamlanivimab, occurring in 19/2355, most commonly fever (n=6), nausea (n=5), and lightheadedness (n=3).ConclusionsAmong high-risk patients with mild to moderate COVID-19, treatment with bamlanivimab was associated with a statistically significant lower rate of hospitalization compared with usual care.FundingMayo Clinic.
Racial disparities in prevalence, determinants, and impacts of COVID-19 in pregnancy: Protocol for a study using data from New Jersey hospitals
Authors: Rokicki Slawa , Nguyen Pauline , Sharpe Alaine , Taylor Dyese , Spernal Suzanne , Raghunath Archana , Kantor Leslie 
Published: May 2021

AbstractIntroductionRacial and ethnic disparities in COVID-19 related infections, hospitalizations, and deaths have been well-documented. However, little research has examined racial and ethnic disparities in COVID-19 prevalence, determinants, and impacts among pregnant women. Within the United States, New Jersey was an early epicenter of the pandemic and experienced high rates of disease in the fall of 2020.MethodsThis study uses data from two New Jersey hospitals, which implemented universal testing of COVID-19 of pregnant women admitted for labor and delivery starting in March 2020. We will estimate prevalence of COVID-19 between March 2020 and November 2020 and compare prevalence rates across race and ethnicity. We will conduct multivariable logistic regression analysis to examine the associations of COVID-19 infection with patient demographic and health status predictors. We will also use multivariable linear and logistic regressions to examine the impact of COVID-19 symptomatic and asymptomatic infection on maternal and infant birth outcomes.DiscussionThis study will generate important policy implications on birth equity in the time of COVID-19 and guide future research studies related to COVID-19 in pregnant women. Results of this study will help to guide interventions and policies to center safe, accessible, and equitable maternity care within the strategic response to the pandemic.
Maximum Parsimony Reconciliation in the DTLOR Model
Authors: Liu Jingyi , Mawhorter Ross , Liu Nuo , Santichaivekin Santi , Bush Eliot , Libeskind-Hadas Ran 
Published: May 2021

AbstractBackgroundAnalyses of microbial evolution often use reconciliation methods. However, the standard duplication-transfer-loss (DTL) model does not account for the fact that species trees are often not fully sampled and thus, from the perspective of reconciliation, a gene family may enter the species tree from the outside. Moreover, within the species tree, genes are often rearranged, causing them to move to new syntenic “regions.”ResultsWe extend the DTL model to account for two events that commonly arise in the evolution of microbes: evolution occurring outside the sampled species tree and changes in the syntenic regions of genes in the genome due to rearrangement. We describe an efficient algorithm for maximum parsimony reconciliation in this new DTLOR model and then show how it can be extended to account for non-binary gene trees. Finally, we describe preliminary experimental results from the integration of our algorithm into the existing xenoGI tool for reconstructing the histories of genomic islands in closely related bacteria.ConclusionsReconciliation in the DTLOR model can offer new insights into the evolution of microbes that is not currently possible under the DTL model.