bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ferroptosis-Related Gene Signature Predicts the Prognosis of Skin Cutaneous Melanoma and Response to Immunotherapy
Authors: Xu Ziqian , Xie Yihui , Mao Yaqi , Huang Juntao , Mei Xingyu , Song Jun , Sun Yue , Yao Zhixian , Shi Weimin 
Published: November 2021

Ferroptosis is a non-apoptotic regulated cell death process, and much research has indicated that ferroptosis can induce the non-apoptotic death of tumor cells. Ferroptosis-related genes are expected to become a biological target for cancer treatment. However, the regulation of ferroptosis-related genes in skin cutaneous melanoma (SKCM) has not been well studied. In the present study, we conducted a systematic analysis of SKCM based on RNA sequencing data and clinical data obtained from The Cancer Genome Atlas (TCGA) database and the FerrD database. SKCM patients from the GSE78220 and MSKCC cohorts were used for external validation. Applying consensus clustering on RNA sequencing data from TCGA the generated ferroptosis subclasses of SKCM, which were analyzed based on the set of differentially expressed ferroptosis-related genes. Then, a least absolute shrinkage and selection operator (LASSO)-Cox regression was used to construct an eight gene survival-related linear signature. The median cut-off risk score was used to divide patients into high- and low-risk groups. The time-dependent receiver operating characteristic curve was used to examine the predictive power of the model. The areas under the curve of the signature at 1, 3, and 5 years were 0.673, 0.716, and 0.746, respectively. Kaplan-Meier survival analysis showed that the prognosis of high-risk patients was worse than that of low-risk patients. Univariate and multivariate Cox regression analyses showed that the risk signature was a robust independent prognostic indicator. By incorporating risk scores with tumor staging, a nomogram was constructed to predict prognostic outcomes for SKCM patients. In addition, the immunological analysis showed different immune cell infiltration patterns. Programmed-death-1 (PD-1) immunotherapy showed more significant benefits in the low-risk group than in the high-risk group. In summary, a model based on ferroptosis-related genes can predict the prognosis of SKCM and could have a potential role in guiding targeted therapy of SKCM.
Longitudinal Analysis of Brain-Predicted Age in Amnestic and Non-amnestic Sporadic Early-Onset Alzheimer's Disease
Authors: Gautherot Morgan , Kuchcinski Grégory , Bordier Cécile , Sillaire Adeline Rollin , Delbeuck Xavier , Leroy Mélanie , Leclerc Xavier , Pruvo Jean-Pierre , Pasquier Florence , Lopes Renaud 
Published: November 2021

Objective:Predicted age difference (PAD) is a score computed by subtracting chronological age from “brain” age, which is estimated using neuroimaging data. The goal of this study was to evaluate the PAD as a marker of phenotypic heterogeneity and severity among early-onset Alzheimer's disease (EOAD) patients.Methods:We first used 3D T1-weighted (3D-T1) magnetic resonance images (MRI) of 3,227 healthy subjects aged between 18 and 85 years to train, optimize, and evaluate the brain age model. A total of 123 participants who met the criteria for early-onset (&lt;65 years) sporadic form of probable Alzheimer's disease (AD) and presented with two distinctive clinical presentations [an amnestic form (n= 74) and a non-amnestic form (n= 49)] were included at baseline and followed-up for a maximum period of 4 years. All the participants underwent a work-up at baseline and every year during the follow-up period, which included clinical examination, neuropsychological testing and genotyping, and structural MRI. In addition, cerebrospinal fluid biomarker assay was recorded at baseline. PAD score was calculated by applying brain age model to 3D-T1 images of the EOAD patients and healthy controls, who were matched based on age and sex. At baseline, between-group differences for neuropsychological and PAD scores were assessed using linear models. Regarding longitudinal analysis of neuropsychological and PAD scores, differences between amnestic and non-amnestic participants were analyzed using linear mixed-effects modeling.Results:PAD score was significantly higher for non-amnestic patients (2.35 ± 0.91) when compared to amnestic patients (2.09 ± 0.74) and controls (0.00 ± 1). Moreover, PAD score was linearly correlated with the Mini-Mental State Examination (MMSE) and the Clinical Dementia Rating Sum of Boxes (CDR-SB), for both amnestic and non-amnestic sporadic forms. Longitudinal analyses showed that the gradual development of the disease in patients was accompanied by a significant increase in PAD score over time, for both amnestic and non-amnestic patients.Conclusion:PAD score was able to separate amnestic and non-amnestic sporadic forms. Regardless of the clinical presentation, as PAD score was a way of quantifying an early brain age acceleration, it was an appropriate method to detect the development of AD and follow the evolution of the disease as a marker of severity as MMSE and CDR-SB.
U-Shaped Association of Aspect Ratio and Single Intracranial Aneurysm Rupture in Chinese Patients: A Cross-Sectional Study
Authors: Yin Jia-He , Su Shi-Xing , Zhang Xin , Bi Yi-Ming , Duan Chuan-Zhi , Huang Wei-mei , Wang Xi-Long 
Published: November 2021

Background: Previous studies have analyzed the association of aspect ratio (AR) on the ruptured intracranial aneurysm (IA), but the findings are inconclusive and controversial. Therefore, the study aimed to derive a more detailed estimation of this association between AR and ruptured IA in Chinese IA patients.Methods: The present work was a cross-sectional study. We retrospectively collected 1,588 Chinese patients with a single IA from January 2010 to November 2017. The relationship was examined between AR at diagnosis and ruptured IA. Covariates included data of demographics, morphological parameters, lifestyle habits, clinical features, and comorbidities. Binary logistic regression and two-piecewise linear models were used to analyze independent associations of AR with ruptured IA.Results: The results suggest that the association between AR and IA rupture was U-shaped. In the AR range of 1.08–1.99, the prevalence of IA rupture was 13% lower for each 0.1-unit increment in AR [odds ratio 0.87, 95% confidence interval (CI) 0.80–0.98]. Conversely, for every 0.1-unit increase in AR, the prevalence of IA rupture increased by ~3% (odds ratio 1.03, 95% CI 1.01–1.06) in the AR range of 3.42–4.08.Conclusion: The relationship between AR and ruptured IA was U-shaped, with the negative association at AR of 1.08–1.99 and positive association at AR of 3.42–4.08.
Icariin Alleviates Wear Particle-Induced Periprosthetic Osteolysis via Down-Regulation of the Estrogen Receptor α-mediated NF-κB Signaling Pathway in Macrophages
Authors: Guangtao Fu , Zhenkang Wen , Zhantao Deng , Mengyuan Li , Qingtian Li , Yuanchen Ma , Yuanfeng Chen , Qiujian Zheng 
Published: November 2021

Periprosthetic osteolysis is one of the major long-term complications following total joint replacement. Its cause is widely accepted to be wear particle-induced activation of inflammatory macrophages. No effective strategy for the prevention and treatment of periprosthetic osteolysis is yet available. Recently, considerable evidence has shown that icariin effectively protects against estrogen deficiency-related bone loss and bone deterioration. However, the molecular mechanism underlying the inhibitory effect of icariin on wear particle-induced periprosthetic osteolysis is not yet clear. In this study, nanoscale CoCrMo wear particles were obtained by high-vacuum three-electrode direct current from the femoral head implant of a patient diagnosed with aseptic loosening. The effects of icariin on wear particle-induced expression of proinflammatory factors, NF-κB signaling modulation, osteolysis, and estrogen receptor α (ERα) activation were evaluated in vitro and in vivo using bone marrow-derived macrophages and C57/BL6J mice, respectively. A possible link between ERα and the protective effect of icariin was further studied using an ERα antagonist and the ERα-siRNA interference. Chemical composition analysis showed that Cr and Co were the major metallic elements of the nanoscale particles, with a mean size of 150.2 ± 37.4 nm for the CoCrMo particles. Following icariin treatment, significant decreases were observed in CoCrMo wear particle-induced TNF-α and IL-6 mRNA expression in BMDMs, and osteolysis in mice calvaria. Marked decreases in the protein expression level of p-IKKβ, p-p65 and p-IκBα were also observed, together with significant decreases in the nuclear import of P65 and macrophage M1 polarization. RNA sequencing revealed that ERα was closely associated with TNF-α and IL-6 in wear particle-stimulated macrophages. Furthermore, marked increases in phospho-ERα Ser118 and phospho-ERα Ser167 protein expression and the nuclear import of ERα were also found in the icariin group. The protective effects of icariin on CoCrMo particle-induced mouse calvarial osteolysis and on the inflammation response in BMDMs were reversed by ERα antagonist and by ERα-siRNA interference. In conclusion, icariin attenuates wear particle-induced inflammation and osteolysis via down-regulation of the ERα-mediated NF-κB signaling pathway in macrophages. The potential application of icariin as a non-hormonal therapy for wear particle-induced periprosthetic osteolysis is worthy of further investigation.
Predicting Survival of Patients With Rectal Neuroendocrine Tumors Using Machine Learning: A SEER-Based Population Study
Authors: Cheng Xiaoyun , Li Jinzhang , Xu Tianming , Li Kemin , Li Jingnan 
Published: November 2021

Background: The number of patients diagnosed with rectal neuroendocrine tumors (R-NETs) is increasing year by year. An integrated survival predictive model is required to predict the prognosis of R-NETs. The present study is aimed at exploring epidemiological characteristics of R-NETs based on a retrospective study from the Surveillance, Epidemiology, and End Results (SEER) database and predicting survival of R-NETs with machine learning.Methods: Data of patients with R-NETs were extracted from the SEER database (2000–2017), and data were also retrospectively collected from a single medical center in China. The main outcome measure was the 5-year survival status. Risk factors affecting survival were analyzed by Cox regression analysis, and six common machine learning algorithms were chosen to build the predictive models. Data from the SEER database were divided into a training set and an internal validation set according to the year 2010 as a time point. Data from China were chosen as an external validation set. The best machine learning predictive model was compared with the American Joint Committee on Cancer (AJCC) seventh staging system to evaluate its predictive performance in the internal validation dataset and external validation dataset.Results: A total of 10,580 patients from the SEER database and 68 patients from a single medical center were included in the analysis. Age, gender, race, histologic type, tumor size, tumor number, summary stage, and surgical treatment were risk factors affecting survival status. After the adjustment of parameters and algorithms comparison, the predictive model using the eXtreme Gradient Boosting (XGBoost) algorithm had the best predictive performance in the training set [area under the curve (AUC) = 0.87, 95%CI: 0.86–0.88]. In the internal validation, the predictive ability of XGBoost was better than that of the AJCC seventh staging system (AUC: 0.90 vs. 0.78). In the external validation, the XGBoost predictive model (AUC = 0.89) performed better than the AJCC seventh staging system (AUC = 0.83).Conclusions: The XGBoost algorithm had better predictive power than the AJCC seventh staging system, which had a potential value of the clinical application.
La equiparación entre los derechos de vecino y de natural en España (Siglos XVII al XIX)
Authors: Salvatto Fabricio Gabriel 
Published: November 2021

Consideramos que las nociones de vecindad y de naturaleza son fundamentales para comprender las formas que adquiere la representación política en la España peninsular del Antiguo Régimen, expresadas en la relación entre el rey y sus súbditos. La condición de súbdito y la vinculación a una dinastía otorgaban al sujeto su lugar en el cuerpo de la sociedad. En la literatura jurídica y política castellana,la categoría de súbditose vincula, coexiste y se superpone con otras de acuerdo con la corporación que lo integra. El vecino alcanza la plenitud de sus potencialidades políticas como miembro del municipio. Bajo Felipe V –a principios del siglo XVIII– se intentaron equiparar las condiciones de vecino y natural. Lo propio sucedería en las Cortes de Cádiz (1810-1812) al proponerse una ciudadanía anclada en estos derechos. Pero dicha equiparación entre vecino y natural no fue posible sino a mediados del siglo XIX.Palabras clave: Vecindad; Naturaleza; España; Antiguo Régimen
Las elecciones legislativas del 2001. Entre el “voto bronca” y el final del gobierno de la Alianza
Authors: Zícari Julián 
Published: November 2021

El presente trabajo intentará dar cuenta de las elecciones legislativas nacionales del año 2001 en la Argentina, buscando señalar que las mismas representaron un suceso inédito en el país a partir de las diversas formas en que actuó la ciudadanía en ellas. Ya que en estas elecciones no sólo se produjo el extraordinario fenómeno conocido como “voto bronca” –el cual se impuso en algunos de los principales distritos–, sino que además fueron uno de los elementos fundamentales para sellar el destino del gobierno de Fernando De la Rúa, quien apenas dos meses después de ellas debió presentar su renuncia a la presidencia. Para hacer esto, repasaremos los resultados electorales a nivel nacional, deteniéndonos en algunos distritos puntuales donde el “voto bronca” actuó con mayor fuerza, tratando de vislumbrar los problemas de su ambigüedad, así como las consecuencias políticas que produjo.Palabras clave: elecciones; 2001; democracia; voto bronca
Guerra Santa y Guerra Justa en el Cercano Oriente Antiguo (CA. 1600-600 A.C.)
Authors: Liverani Mario 
Published: November 2021

En los reinos –y sobre todo en los denominados “imperios”– del Cercano Oriente antiguo la ampliación de las fronteras es un motivo ideológico constante. El significado ideológico reside en la contraposición de un territorio interno de carácter cósmico y un territorio externo de carácter caótico. Dados los propósitos de cumplimiento del orden cósmico, la guerra asume un carácter santo ya que es el instrumento de la justa sumisión de la periferia al reino central. Ampliando el territorio interno a costa del territorio externo, el soberano se inserta en la secuencia de los personajes heroicos que han contribuido al ordenamiento del mundo.Si bien el soberano legítimo inicia su acción bélica justa por mandato divino la guerra debe ser, asimismo, justa a nivel de evaluación humana, en el ámbito del sistema de valores civiles y jurídicos que están en curso en una determinada cultura.En este artículo se estudian aspectos que develan la lógica y la justificación de la guerra entre los estados del Cercano Oriente antiguo. Palabras clave: Cercano Oriente antiguo; guerra; legitimación
Reseñas Bibliográficas
Authors: Mangold Florencia , Bocasso Nicolás 
Published: November 2021

Nieto, Agustín y Videla, Oscar (2018). El anarquismo después del anarquismo. Una historia espectral. Mar del Plata: Ed. GESMar (Grupo de Estudios Sociales Marítimos) 1° ed. Disponible en: https://gesmar.estudiosmaritimossociales.org/editorial/coleccion-anarquismos/el-anarquismo-despues-del-anarquismo/
Watts, Edward J. (2019). República mortal. Cómo cayó Roma en la tiranía. Barcelona: Galaxia Gutemberg [320 páginas]
Implicancias de las alteraciones en la función ventricular en pacientes con Accidente Cerebrovascular Isquémico.
Authors: Saavedra Gisela Nancy , Tavolini Darío , Jairala Juan Ignacio 
Published: November 2021

En este estudio se quiso demostrar el impacto de la Insuficiencia Cardiaca en pacientes que presentaron ACV isquémico, en la recuperación funcional y pronóstico durante la internación, tanto en pacientes con diagnóstico clínico de Insuficiencia Cardíaca como en pacientes asintomáticos, relacionando disfunción ventricular sistólica y diastólica. Se realizó un estudio prospectivo, observacional. Se evaluaron 112 pacientes con ACV isquémico, se dividieron en tres grupos, según la función ventricular izquierda: pacientes con Función Ventricular Normal, pacientes con Función Sistólica Alterada y pacientes con Función Diastólica Alterada. Se comparó en cada grupo la escala NIHSS (al ingreso, 48 hs y alta), el pronóstico funcional, complicaciones neurológicas y extra neurológicas. El grupo con Función Sistólica Alterada se relacionó con mayor incidencia de complicaciones clínicas y neurológicas, también en el grupo con Función Diastólica Alterada, pero de menor proporción. En ambos grupos se observó mayor mortalidad, con respecto a pacientes con Función Ventricular Normal. El grupo de pacientes con Función Sistólica Alterada presentó peor pronóstico funcional, con un empeoramiento durante la internación. Presentaron peor pronóstico de enfermedad inicial y de la recuperación evaluada a corto plazo, durante la internación. El grupo de pacientes con Función Diastólica Alterada presentó un mal pronóstico funcional aunque de menor proporción que el anterior. Se asoció a un empeoramiento significativo durante la internación, tanto de los pacientes que presentaron buen pronóstico como malo.
Acalabrutinib-Related Cardiac Toxicities in Patients with Chronic Lymphocytic Leukemia: A Meta-Analysis of Randomized Controlled Trials
Authors: Htut Thura Win , Han Myat Min , Thein Kyaw Zin 
Published: November 2021

ABSTRACT
Acalabrutinib, a second-generation and more selective Bruton's tyrosine kinase inhibitor, was developed to potentiate efficacy while minimizing ibrutinib-associated side effects. We undertook a systematic review and meta-analysis of randomized clinical trials to determine the risks of acalabrutinib-related cardiac toxicities in patients with chronic lymphocytic leukemia. Patients on acalabrutinib experienced higher risk of any-grade cardiac events (risk ratio, 1.75; p = 0.01) while there was a considerable trend toward statistical significance in the risk of any-grade atrial fibrillation (risk ratio, 2.56; p = 0.05). There was no significant increase in the risk of hypertension or high-grade cardiac events or atrial fibrillation in the acalabrutinib group.
ANALISIS EFEKTIVITAS BIAYA PERBANDINGAN KOMBINASI METFORMIN-GLIMEPIRIDE DAN INSULIN ASPART-INSULIN DETEMIR PASIEN RAWAT JALAN PESERTA BPJS PENDERITA DIABETES MELITUS TIPE 2 DI RSUD TOTO KABILA
Authors: Diantika Ana Ana , S.Farm., M.Sc., Apt Madania Madania , S.Si., M.Si., Apt Dr Nur Rasdianah 
Published: November 2021

Diabetes Melitus tipe 2 merupakan kelompok penyakit metabolik dengan karakteristik ditandai hiperglikemia yang terjadi karena resistensi insulin dan kegagalan relatif sel beta. Bervariasinya penggunaan terapi kombinasi insulin atau kombinasi antidiabetik oral pada pasien DM tipe 2dengan glukosa darah yang belum adekuat akan mengakibatkan adanya berbedaan dalam biaya dan efektivitas terapinya. Penelitian ini merupakan penelitian deskriptif yang dilakukan secara retrospektif dari bulan Oktober sampai dengan Desember 2020. Subyek penelitian adalah 45 pasien DM tipe 2 yang memenuhi kriteria inklusi. Data dianalisis untuk mengetahui jenis terapi dan biaya medis langsung. Efektivitas terapi dinilai dari tercapainya target (GDS 110-130 mg/dL) selama 3 bulan pasien melakukan kontrol kesehatan tidak munculnya efek samping obat (hipoglikemia). Data diolah menggunakan ACER dan ICER. Hasil Penelitian menunjukkan jumlah pasien DM tipe 2 lebih banyak diderita oleh perempuan yaitu 26 orang dengan persentase 57,8%, berdasarkan usia pada kelompok 44-52 tahun yaitu 18 oang dengan persentase 40%. Efektivitas pengobatan kombinasi metformin-glimepiride 51,6%, dan kombinasi insulin aspart-insulin detemir 93%. Berdasarkan nilai ACER yang paling cost effective adalah kombinasi metformin-glimepiride dengan nilai ACER sebesar Rp 101.082,364 per % efektivitas.
Tidal Evolution of the Eccentric Moon around Dwarf Planet (225088) Gonggong
Authors: Arakawa Sota , Hyodo Ryuki , Shoji Daigo , Genda Hidenori 
Published: November 2021

Abstract
Recent astronomical observations revealed that (225088) Gonggong, a 1000 km sized trans-Neptunian dwarf planet, hosts an eccentric satellite, Xiangliu, with an eccentricity of approximately 0.3. As the majority of known satellite systems around trans-Neptunian dwarf planets have circular orbits, the observed eccentricity of the Gonggong–Xiangliu system may reflect the singular properties of the system. In this study, we assumed that the Gonggong–Xiangliu system formed via a giant impact and we investigated the subsequent secular tidal evolution of this system under the simplifying assumptions of homogeneous bodies and of zero orbital inclination. We conducted simulations of coupled thermal–orbital evolution using the Andrade viscoelastic model and included higher-order eccentricity functions. The distribution of the final eccentricity from a large number of simulations with different initial conditions revealed that the radius of Xiangliu is not larger than 100 km. We also derived the analytical solution of the semilatus rectum evolution, a function of the radius of Xiangliu. From the point of view of the final semilatus rectum, the radius of Xiangliu was estimated to be close to 100 km. Together with the results of the Hubble Space Telescope observations, our findings suggest Gonggong and Xiangliu have similar albedos.
Introducing the FLAMINGOS-2 Split-K Medium-band Filters: The Impact on Photometric Selection of High-z Galaxies in the FENIKS-pilot survey
Authors: Esdaile James , Labbé Ivo , Glazebrook Karl , Antwi-Danso Jacqueline , Papovich Casey , Taylor Edward , Marsan Z. Cemile , Muzzin Adam , Straatman Caroline M. S. , Marchesini Danilo , Diaz Ruben , Spitler Lee , Tran Kim-Vy H. , Goodsell Stephen 
Published: November 2021

Abstract
Deep near-infrared photometric surveys are efficient in identifying high-redshift galaxies, however, they can be prone to systematic errors in photometric redshift. This is particularly salient when there is limited sampling of key spectral features of a galaxy’s spectral energy distribution (SED), such as for quiescent galaxies where the expected age-sensitive Balmer/4000 Å break enters the K-band at z > 4. With single-filter sampling of this spectral feature, degeneracies between SED models and redshift emerge. A potential solution to this comes from splitting the K band into multiple filters. We use simulations to show an optimal solution is to add two medium-band filters, K
blue (λ
cen = 2.06 μm, Δλ = 0.25 μm) and K
red (λ
cen = 2.31 μm, Δλ = 0.27 μm), that are complementary to the existing K
s filter. We test the impact of the K-band filters with simulated catalogs comprised of galaxies with varying ages and signal-to-noise. The results suggest that the K-band filters do improve photometric redshift constraints on z > 4 quiescent galaxies, increasing precision and reducing outliers by up to 90%. We find that the impact from the K-band filters depends on the signal-to-noise, the redshift, and the SED of the galaxy. The filters we designed were built and used to conduct a pilot of the FLAMINGOS-2 Extragalactic Near-Infrared K-band Split survey. While no new z > 4 quiescent galaxies are identified in the limited area pilot, the K
blue and K
red filters indicate strong Balmer/4000 Å breaks in existing candidates. Additionally, we identify galaxies with strong nebular emission lines, for which the K-band filters increase photometric redshift precision and in some cases indicate extreme star formation.