bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leveraging epigenomes and three-dimensional genome organization for interpreting regulatory variation
Authors: Baur Brittany , Schreiber Jacob , Shin Junha , Zhang Shilu , Zhang Yi , Manjunath Mohith , Song Jun S. , Noble William Stafford , Roy Sushmita 
Published: August 2021

AbstractUnderstanding the impact of regulatory variants on complex phenotypes is a significant challenge because the genes and pathways that are targeted by such variants are typically unknown. Furthermore, a regulatory variant might influence a particular gene’s expression in a cell type or tissue-specific manner. Cell-type specific long-range regulatory interactions that occur between a distal regulatory sequence and a gene offers a powerful framework for understanding the impact of regulatory variants on complex phenotypes. However, high-resolution maps of such long-range interactions are available only for a handful of model cell lines. To address this challenge, we have developed L-HiC-Reg, a Random Forests based regression method to predict high- resolution contact counts in new cell lines, and a network-based framework to identify candidate cell line-specific gene networks targeted by a set of variants from a Genome-wide association study (GWAS). We applied our approach to predict interactions in 55 Roadmap Epigenome Consortium cell lines, which we used to interpret regulatory SNPs in the NHGRI GWAS catalogue. Using our approach, we performed an in-depth characterization of fifteen different phenotypes including Schizophrenia, Coronary Artery Disease (CAD) and Crohn’s disease. In CAD, we found differentially wired subnetworks consisting of known as well as novel gene targets of regulatory SNPs. Taken together, our compendium of interactions and associated network-based analysis pipeline offers a powerful resource to leverage long-range regulatory interactions to examine the context-specific impact of regulatory variation in complex phenotypes.
Endothelial integration of mechanosensory signals by the spectrin cytoskeleton
Authors: Mylvaganam Sivakami , Yusuf Bushra , Li Ren , Lu Chien-Yi , Robinson Lisa A. , Freeman Spencer A. , Grinstein Sergio 
Published: August 2021

AbstractPhysiological blood flow induces the secretion of vasoactive compounds, notably NO, and promotes endothelial cell elongation and reorientation parallel to the direction of applied shear. How shear is sensed and relayed to intracellular effectors is incompletely understood. We demonstrate that an apical spectrin network is essential to convey the force imposed by shear to endothelial mechanosensors. By anchoring CD44, spectrin modulates the cell surface density of hyaluronan, which senses and translates shear into changes in plasma membrane tension. Spectrins also regulate the stability of apical caveolae, where the mechanosensitive Piezo1 channels are thought to reside. Accordingly, shear-induced Piezo1 activation and the associated calcium influx were absent in spectrin-deficient cells. As a result, cell realignment and flow-induced eNOS stimulation were similarly dependent on spectrin. We concluded that the apical spectrin network is not only required for shear sensing, but transmits and distributes the resulting tensile forces to mechanosensors that elicit protective and vasoactive responses.
A novel regulatory gene promotes novel cell fate by suppressing ancestral fate in the sea anemone Nematostella vectensis
Authors: Babonis Leslie S , Enjolras Camille , Ryan Joseph F , Martindale Mark Q 
Published: August 2021

AbstractCnidocytes (“stinging cells”) are an unequivocally novel cell type used by cnidarians (corals, jellyfish, and their kin) to immobilize prey. Although they are known to share a common evolutionary origin with neurons, the developmental program that promoted the emergence of cnidocyte fate is not known. Using functional genomics in the sea anemone, Nematostella vectensis, we show that cnidocytes evolved by suppression of neural fate in a subset of neurons expressing RFamide. We further show that a single regulatory gene, a C2H2-type zinc finger transcription factor (ZNF845), coordinates both the gain of novel (cnidocyte-specific) traits and the inhibition of ancestral (neural) traits during cnidocyte development and that this gene arose by domain shuffling in the stem cnidarian. Thus, we uncover a mechanism by which a truly novel regulatory gene (ZNF845) promoted the origin of a truly novel cell type (cnidocyte) through duplication of an ancestral cell lineage (neuron) and inhibition of its ancestral identity (RFamide).SignificanceIn this study, we demonstrate how new cell types can arise in animals through duplication of an ancestral (old) cell type followed by functional divergence of the new daughter cell. Specifically, we show that stinging cells in cnidarians (jellyfish and corals) evolved by duplication of an ancestral neuron followed by inhibition of the RFamide neuropeptide it once secreted. This is the first evidence that stinging cells evolved from a specific subtype of neurons and suggests some neurons may be easier to co-opt for novel functions than others.
Alternative Covid-19 mitigation measures in school classrooms: analysis using an agent-based model of SARS-CoV-2 transmission
Authors: Woodhouse M. J. , Aspinall W. P. , Sparks R. S. J. , Pollock E. Brooks , Relton C. 
Published: August 2021

1.AbstractThe SARS-CoV-2 epidemic continues to have major impacts on children’s education, with schools required to implement infection control measures that have led to long periods of absence and classroom closures. We have developed an agent-based epidemiological model of SARS-CoV-2 transmission that allows us to quantify projected infection patterns within primary school classrooms, and related uncertainties; the basis of our approach is a contact model constructed using random networks, informed by structured expert judgement. The effectiveness of mitigation strategies are considered in terms of effectiveness at supressing infection outbreaks and limiting pupil absence. Covid-19 infections in schools in the UK in Autumn 2020 are re-examined and the model used for forecasting infection levels in autumn 2021, as the more infectious Delta-variant was emerging and school transmission thought likely to play a major role in an incipient new wave of the epidemic. Our results were in good agreement with available data. These findings indicate that testing-based surveillance of infections in the classroom population with isolation of positive cases is a more effective mitigation measure than bubble quarantine, both for reducing transmission in primary schools and for avoiding pupil absence, even accounting for insensitivity of self-administered tests. Bubble quarantine entails large numbers of pupils being absent from school, with only modest impact on classroom infection levels. However, maintaining reduced contact rates within the classroom can have a major beneficial impact for managing Covid-19 in school settings.
Impact of information and communication technologies (ICT) on student’s learning: a case from university of the Punjab, Pakistan
Authors: Ahmad Toqeer , Sheikh Arslan 
Published: August 2021

PurposeThis study aims to investigate the impact of information and communication technologies (ICT) on student’s learning primarily concentrating on the following factors: including availability, accessibility and user-ability of using ICT resources. This investigation will highlight the role of ICT in the pedagogical activities of students, especially in their learning.Design/methodology/approachA questionnaire was designed to comprehend the questions related to the objectives and a sample of 275 students through convenience sampling technique was selected that was enrolled in various degree programs of the University of the Punjab, Pakistan. Primarily the descriptive analysis was made and data were presented in tabulated form. However, for inferential analysis, the Pearson correlation test was applied to determine the relationship among the dependent and independent variables including (availability, accessibility user-ability and student’s learning) and to test the hypotheses of the study.FindingsThe findings disclose that students at the University of the Punjab have access to various kinds of ICT applications and resources. Moreover, they have an adequate number of ICT equipment available for their use and they are familiar with various kinds of ICT applications and resources which they use in various educational tasks during their studies. A strong positive linear correlation exists between availability, accessibility and user-ability of using ICT resources and the student’s educational learning. This confirms that ICT plays a significant role in the student’s educational accomplishments. It helps students in searching, retrieving and consulting various types of information sources. It also helps them in completing their educational tasks in a quick manner. Students at all levels also see it as a matter of great importance to acquire ICT-related skills as this can help them to be more productive in their educational accomplishments.Originality/valueThis study concludes that availability, accessibility, adequacy and user ability to use the ICT resources positively impact students learning. Therefore, it is highly recommended for students to learn ICT-related skills and to make the best use of the different communication technologies in their pedagogical activities. Moreover, if academic institutions in Pakistan give more emphasis on developing ICT-based infrastructure and ICT skilled manpower then this can also bring fruitful results in the learning process of student’s educational endeavors.
Celebrity CEOs’ credibility, image of their brands and consumer materialism
Authors: Huaman-Ramirez Richard , Merunka Dwight 
Published: August 2021

Purpose
This paper aims to model and estimate how celebrity chief executive officers (CEOs) credibility (i.e. expertise, trustworthiness, attractiveness) is related to their brand image (i.e. functional, sensory/visual). This paper further examines the effects of consumer materialism on both celebrity CEOs’ credibility and the image of their brand.

Design/methodology/approach
A total of 260 participants knowledgeable of CEOs and their corresponding brands completed an online questionnaire in a cross-sectional study. The data were analyzed through covariance-based structural equation modeling.

Findings
Celebrity CEOs’ expertise and attractiveness are positively related to both functional and sensory/visual images of their brands. Results also demonstrate the positive effect of materialism on both celebrity CEOs’ credibility and brand image.

Research limitations/implications
The research was conducted in one country (France) using a cross-sectional design. Additional studies in other settings or countries should be carried out to establish the generalizability of results and strengthen causality inferences.

Practical implications
CEOs need to understand and manage their key role as celebrities, given the direct influence they may have on consumer brand perceptions and behavior.

Originality/value
This study refines the relationship between celebrity CEOs’ credibility and brand image. It is the first to introduce and validate the effect of consumer materialism on the perception of celebrity CEOs.
Exploring the application of property graph model in visualizing COBie data
Authors: Kumar Vishal , Teo Evelyn Ai Lin Evelyn 
Published: August 2021

Purpose
The usability aspect of the construction operations building information exchange (COBie) datasheet has been largely overlooked. Users find it difficult to find relevant data inside COBie and understand the dependencies of information. This research study is a part of a more comprehensive research study to identify the usability issues associated with COBie and propose solutions to deal with them. This paper aims to discuss the challenges associated with the visualization aspect of COBie and proposes a solution to mitigate them.

Design/methodology/approach
This paper is based on design thinking and waterfall methodology. While the design thinking methodology is used to explore the issues associated with the visualization aspect of COBie, the waterfall methodology is used to develop a working prototype of the visualizer for the COBie datasheet using a spreadsheet format.

Findings
The paper demonstrates that the property graph model based on a node-link diagram can be effectively used to represent the COBie datasheet. This will help in storing data in a visually connected manner and looking at links more dynamically. Moreover, converting and storing data into an appropriate database will help reach data directly rather than navigate multiple workbooks. This database can also help get the history of data inside the COBie datasheet as it develops throughout the project.

Originality/value
This research proposes a novel approach to visualize the COBie datasheet interactively using the property graph model, a type of node-link diagram. Using the property graph model will help users see data in a connected way, which is currently missing in the spreadsheet representation of COBie data. Moreover, this research also highlights that storing historical changes in COBie data can help understand how data has evolved throughout the construction. Additionally, structured storage of data in relationship format can help users to access the end of connected data directly through the efficient search.
Editorial: business education in profound disruption
Authors: Rosenbaum Mark Scott , Russell-Bennett Rebekah , Contreras-Ramírez Germán 
Published: August 2021

Purpose
This editorial aims to discuss 11 trends that are driving changes in business education, especially for Master of Business Administration (MBA) curriculum programming.

Design/methodology/approach
The editorial provides introspection, personal reflections and conceptualization using current literature.

Findings
The authors discuss 11 drivers that are influencing graduate business education. These drivers include the demographic cliff, the K-shaped recovery, MBA degrees losing their allure, emergence of two pricing structures, the rise of online universities, certificates and micro-credentials, the massive open online course (MOOC) MBA programs, MOOCs and certification, Grow with Google, Outsourcing MBA instruction and business education relevancy.

Research limitations/implications
Traditional university and college graduate business education providers must realize that the educational industry is experiencing a revolutionary disruption and that many universities will fail to meet learners’ expectations for relevant skills and organizational demands for employees who have specific skills for employability.

Practical implications
Learners will no longer rely on traditional four-year universities to obtain business skills.

Originality/value
This work synthesizes a disparate set of drivers that are affecting all graduate business educational providers.
Hosting persons with mental illness: narrative study on the experiences of a female caregiver managing a mental home in Ghana
Authors: Amissah-Essel Salome , Ebu Enyan Nancy Innocentia , Asiedu Christiana 
Published: August 2021

Purpose
Persons with mental illness (PWMI) need to be housed and cared for properly. Providing this support can be physically, financially and psychologically exhausting for the caregiver. The purpose of this study was to explore the lived experiences of a caregiver managing a mental home in Ghana and to get a deeper understanding of what it really takes to host and care for PWMI.

Design/methodology/approach
A narrative research design was used. The narrative approach was used to gather the stories of the caregiver. Data was collected through in-depth face-to-face interview, informal conversations and field notes. Thematic analysis was performed focusing on both the personal and social experiences of the participant.

Findings
Three main themes emerged from the participant’s experience as follows: stigma and rejection, burden of hosting and support from others. The study also found that what it takes to host and care for PWMI is psychological resilience as follows: determination and love. An appeal is made to individuals to also support PWMI instead of the government alone.

Originality/value
The outcomes of this study indicate that the life of a caregiver managing a mental home is a journey characterized by stigma, rejection and financial burden. It highlights the importance of support from others for the caregiver to keep providing optimal care. This paper contributes to the literature on carer resilience by providing evidence that once there is determination and love, PWMI can be housed and cared for in Ghana.
The long-term effects of section transfers on return volatility: Intraday and overnight periods
Authors: Abo Rodrigue Majoie 
Published: August 2021

Purpose
Studies on transfers to a more regulated section show an increase in information disclosure and stocks’ liquidity levels. Classical theories suggest that volatility should also be reduced. This study aims to analyse the long-term effects of a section transfer to a more regulated section (TSE 1/TSE 2) on stock return volatility.

Design/methodology/approach
This study uses an empirical framework relying on two-sample t-tests and panel regressions. These use robust standard errors and control for fixed effects, day effects and macroeconomic factors. The return variance of comparable stocks’ benchmark sample, instead of market variance, is used as a control variable. Comparable stocks operate within the same industry and do not transfer during the sample period. The authors test our results’ robustness using generalized autoregressive conditional heteroskedasticity estimates.

Findings
The study’s main findings show that pre-transferred stocks are more volatile than the stocks’ benchmark sample. The transfer to a more regulated section leads to a gradual decrease in the total daily stock return volatility, intraday return volatility and overnight return volatility.

Originality/value
To the best of my knowledge, this study is the first to empirically address the volatility change caused by the stocks’ transfer to a more regulated section. This study highlights the benefits of choosing section transfers to reduce volatility.
Association between hepatitis C virus infection and subsequent chronic inflammatory skin disease
Authors: Ma Sheng‐Hsiang , Tai Ying‐Hsuan , Dai Ying‐Xiu , Chang Yun‐Ting , Chen Tzeng‐Ji , Chen Mu‐Hong 
Published: August 2021

AbstractHepatitis C virus (HCV) infection is associated with several cutaneous manifestations, including lichen planus and psoriasis. However, its association with other chronic inflammatory skin diseases (CISD) remains largely unknown. The aim of this study was to investigate the association between HCV infection and CISD. Participants were recruited from the National Health Insurance Research Database in Taiwan. Altogether 23 509 patients with HCV infection and 94 036 matched controls were included to assess the risk of CISD. A Cox regression model was used for the analyses. Compared with controls, patients with HCV infection had an adjusted hazard ratio (aHR) of 6.34 (95% confidence interval [CI], 5.30–7.58) for CISD after adjustment for potential confounders. Regarding individual CISD, patients with HCV infection had a significantly increased risk of developing lichen planus, psoriasis, vitiligo, alopecia areata, and cutaneous lupus erythematosus. Interferon‐based antiviral therapy (IFN‐based AVT) was significantly associated with a decreased risk of CISD (aHR = 0.42; 95% CI, 0.28–0.64). Patients with HCV infection had a significantly increased risk of CISD, while IFN‐based AVT was associated with a decreased risk. These findings suggest monitoring of CISD in patients with HCV infection.
Nontargeted 1H NMR fingerprinting and multivariate statistical analysis for traceability of Greek PDO Vostizza currants
Authors: Dimitrakopoulou Maria‐Eleni , Matzarapi Konstantina , Chasapi Styliani , Vantarakis Apostolos , Spyroulias Georgios A. 
Published: August 2021

AbstractIn this study, non‐targeted 1H NMR fingerprinting was used in combination with multivariate statistical analyses for the classification of Greek currants based on their geographical origins (Aeghion, Nemea, Kalamata, Zante, and Amaliada). As classification techniques, Principal Component Analysis (PCA) and Partial Least Squares Discriminant Analysis (PLS‐DA) were carried out. To elucidate different components according to PDO (Protected Designation of Origin), products from Aeghion (Vostizza) were statistically compared with each one of the four other regions. PLS‐DA plots ensure that currants from Kalamata, Nemea, Zante, and Amaliada are well classified with respect to the PDO currants, according to differences observed in metabolites. Results suggest that composition differences in carbohydrates, amino, and organic acids of currants are sufficient to discriminate them in correlation to their geographical origin. In conclusion, currants metabolites which mostly contribute to classification performance of such discriminant analysis model present a suitable alternative technique for currants traceability. The study results contribute information to the currants’ metabolite fingerprinting by NMR spectroscopy and their geographical origin.Practical ApplicationThis study presents an analytical approach for a high nutritional value Greek PDO product, Vostizza currant. A further research and implementation of this method in food industry, can be the key to food fraud incidents. Thus, application of this work opens up posibilities to “farm to table” mission.
A comparative study of photoresponsive molecularly imprinted polymers with different shell thicknesses: Effects on 6‐O‐α‐maltosyl‐β‐cyclodextrin separation
Authors: Fan Haoran , Wang Jing , Xu Xueming , Jin Zhengyu , Wang Jinpeng 
Published: August 2021

AbstractPhotoresponsive surface molecularly imprinted polymers (PSMIPs) with controlled nanoshell thicknesses were synthesized using different amounts of precursor materials to determine the effects of polymer shell layer thickness on the separation and purification of 6‐O‐alpha‐maltosyl‐beta‐cyclodextrin (Mal‐β‐CD). The physicochemical properties and adsorption and desorption capacities of PSMIPs with different shell thicknesses were studied. Interestingly, the uniform thickness of the imprinted polymer shell layer could be adjusted from 10 to 60 nm by varying the amount of polymerization precursors, and the average mesopore diameter of PSMIPs was not significantly affected by shell thickness. However, the removal efficiency and selective capacity of PSMIPs on Mal‐β‐CD were strongly correlated to their shell thickness. The adsorption behavior of PSMIPs on Mal‐β‐CD fitted well with the Langmuir adsorption model and pseudo‐second‐order kinetic model. Based on the obtained results, PSMIPs with a 30‐nm imprinted layer were found to be an excellent adsorbent for Mal‐β‐CD separation, with an adsorption capacity of 18.12 mg/g. They can therefore be used for industrial chromatographic separations of Mal‐β‐CD in the future.Practical ApplicationThis article clearly demonstrated that the shell thickness of core‐shell molecularly imprinted materials affected the degree and rate of cyclodextrin separation. Determining the optimal thickness is of great significance for the material in the separation and purification of cyclodextrin.