bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemanfaatan Ekstrak Daun Sirih Hijau (Piper Betle L.) Sebagai Zat Pewarna Alami (ZPA) Tekstil Dan Aplikasinya pada Benang Tenun
Authors: Afan Muhamad , Wiraningtyas Agrippina , Agustina Sry , R Ruslan 
Published: February 2021

Penelitian ini bertujuan untuk memanfaatkan daun Sirih (Piper Betle L.) sebagai zat warna alam pada tekstil. Tahap pengolahan Pemanfaatan Ekstrak Warna Daun Sirih Hijau (Piper Betle L.) ZPA (Zat Pewarna Alami) Tekstil Pada Aplikasi Benang Tenun Bima dilakukan melalui beberapa tahapan diantaranya ekstraksi zat pewarna alam, mordanting, pewarnaan dan proses fiksasi. Hasil pewarnaan benang dapat dilihat perubahan warna yang dihasilkan, benang yang awalnya berwarna putih tetapi mengalami perubahan warna setelah direndam dalam zat warna ekstrak daun sirih hijau. Warna yang dihasilkan yaitu untuk variasi maserasi 1, 3, 4 dan 5 jam berwarna putih kecoklatan sedangkan untuk variasi maserasi 2 jam benang berwarna putih keemasan. Sedangkan dari hasil pengujian yang dilakukan pengaruh dari zat fiksator tawas menghasilkan warna seperti warna asli sebelum melalui proses fiksasi warna yang dihasilkan dalam penelitian ini secara indera penglihatan berwarna putih, pada zat fiksator tunjung menghasilkan warna kearah yang lebih gelap warna yang dihasilkan dalam penelitian ini secara indera penglihatan berwarna kuning keemasan sedangkan dengan fiksasi kapur tohor menghasilkan warna yang berseberangan dari warna asli dan warna yang dihasilkan adalah warna putih kecoklatan.
Pengaruh Capital Adequacy Ratio dan Beban Operasional Terhadap Pendapat Operasional Terhadap Return on Asset Pada PT Bank Mandiri (Persero) Tbk
Authors: Janudin Janudin , Khotijah Siti 
Published: February 2021

This study aims to determine the effect and impact of the Capital Adequacy Ratio (X1 ) and Operational Expenses on Operating Income (X2 ) on Return on Assets (Y) at PT Bank Mandiri (Persero). Tbk. The method used is explanatory research. The analysis technique uses statistical analysis with regression testing, correlation, determination and hypothesis testing. The results of the research conducted indicate that the Capital Adequacy Ratio (X1 ) does not have a significant effect on Return on Assets (Y), the determination value is 74.8%, the hypothesis test is obtained by count <ttable or (- 3.851 <2.571). Operational Expense on Operating Income (X2 ) has no significant effect on Return on Assets (Y) with a determination value of 97.1%, hypothesis testing is obtained tcount <ttable or (- 13.010 <2.571). Capital Adequacy Ratio (X1 ) and Operating Expenses to Operating Income (X2 ) simultaneously have a significant effect on Return on Assets (Y), the regression equation Y = 8,202 - 0.017X1 - 0.074X2 and a determination value of 97.4%, hypothesis testing is obtained with Fcount> Ftable or (73,717> 6,590).
Abstrak
Penelitian ini bertujuan untuk mengetahui Pengaruh Capital Adequecy Ratio (X1) dan Beban Operasional terhadap Pendapatan Operasional (X2) Terhadap Return on Asset (Y) Pada PT. Bank Mandiri (Persero). Tbk. Metode yang digunakan adalah explanatory research. Teknik analisis menggunakan analisis statistik dengan pengujian regresi, korelasi, determinasi dan uji hipotesis. Hasil penelitian ini Capital Adequecy Ratio (X1) tidak berpengaruh signifikan terhadap Return on Asset (Y), nilai determinasi sebesar 74,8%, uji hipotesis diperoleh t hitung < t tabel atau (- 3,851 < 2,571). Beban Operasional terhadap Pendapatan Operasional(X2) tidak berpengaruh signifikan terhadap Return on Asset (Y) dengan nilai determinasi sebesar 97,1%, uji hipotesis diperoleh t hitung < t tabel atau (- 13,010 < 2,571). Capital Adequecy Ratio (X1) dan Beban Operasional terhadap Pendapatan Operasional (X2) secara simultan berpengaruh signifikan terhadap Return on Asset (Y) diperoleh persamaan regresi Y = 8,202 - 0.017X1 - 0.074X2 dan nilai determinasi sebesar 97,4%, uji hipotesis diperoleh nilai F hitung > F tabel atau (73,717 > 6,590)
Kata Kunci : Capital Adequacy Ratio, Beban Operasional terhadap Pendapatan Operasional, Return on Asset
Pengaruh Media Digital Interaktif terhadap Keputusan Pembelian
Authors: Putra Hanif Firmansyah , Yandri Pitri 
Published: February 2021

The era of digitalization which is an era where everyone uses digital means as a medium of communication and a means of communication. The use of this media is considered very effective and has a tremendous impact on its users, the phenomenon of online shopping is growing rapidly. The current availability of a marketplace is very helpful in finding a product, such as Tokopedia, which is the largest online shopping marketplace in Indonesia. The purpose of this study was to determine the effect of interactive digital media on online product purchasing decisions. The population in this study are active users of the Tokopedia marketplace who have made purchases in the South Tangerang City area. The sampling technique in this study was to use purposive sampling technique. The sample in this study were as many as 64 respondents. The data analysis technique used in this research is Structural Equation Modeling using SmartPLS. The results of the study show that the existence of digital media can influence potential consumers to make purchase transactions, seen through each indicator of the digital media variable, namely the website and social networking Instagram, which shows significant positive results on the decision to purchase fashion products on the Tokopedia marketplace.
Abstrak
Era digitalisasi yang merupakan era di mana setiap orang menggunakan sarana digital sebagai media penghubung dan alat komunikasi. Penggunaan media ini dinilai sangat efektif dan memberikan dampak yang luar biasa kepada penggunanya, fenomena berbelanja secara daring semakin berkembang pesat. Ketersedian marketplace saat ini sangat membantu dalam pencarian suatu produk, seperti Tokopedia yang merupakan marketplace berbelanja daring terbesar di Indonesia. Tujuan penelitian ini adalah untuk mengetahui pengaruh media digital interaktif terhadap keputusan pembelian produk secara online. Populasi dalam penelitian ini adalah pengguna aktif marketplace Tokopedia yang pernah melakukan pembelian yang berada pada wilayah Kota Tangerang Selatan. Teknik pengambilan sampel dalam penelitian ini yaitu dengan menggunakan teknik purposive sampling. Sampel pada penelitian ini adalah sebanyak sebanyak 64 responden. Tekhnik analisis data yang di gunakan dalam penelitian ini adalah dengan Structural Equation Modeling menggunakan SmartPLS. Hasil penelitian dapat diketahui bahwa dengan adanya media digital dapat mempengaruhi calon konsumen untuk melakukan transaksi pembelian, dilihat melalui setiap indikator dari variabel media digital yaitu website dan jejaring sosial instagram menunjukan hasil positif signifikan terhadap keputusan pembelian produk fashion di marketplace Tokopedia.
Kata Kunci : Media Digital, Website, Media Jejaring Sosial Instagram, Keputusan Pembelian Online, Model Persamaan Struktural
Pengaruh Pemahaman Sistem Keuangan dan Pengawasan Kinerja terhadap Fungsi Keuangan
Authors: Praditya Alvin , Wibowo Wahyu Andri , Komala Laura 
Published: February 2021

The purpose of this study is to determine the effect of understanding the financial system and monitoring performance on financial functions at the Sasmita Jaya Foundation, Pamulang University. The method used in this research is quantitative descriptive. Analysis, then statistical testing is carried out to measure how much influence the variables under study and the statistical calculation process. While The population in this study was 33 and all members of the population were sampled for respondent determination. The sampling technique used saturated sampling. The simultaneous influence between financial system understanding (X1) and performance monitoring (X2) on financial functions (Y). This is evidenced by the value of R Square =0.249, it can be concluded that, understanding the financial system (X1) and performance supervision (X2) on financial functions (Y) is 24.9% and the remaining 75.1% is influenced by other factors. Hypothesis test shows the value of Fcount 4.982>Ftable 3.32 or probability sig 0.014<0.05 then H01 is rejected and Ha1 is accepted, meaning it is significant, thus the proposed hypothesis determines that there is a simultan influence between the understanding of the financial system (X1) and performance supervision (X2) on financial functions (Y) at the Sasmita Jaya Foundation, Pamulang University.

Abstrak
Tujuan penelitian ini untuk mengetahui pengaruh pemahaman sistem keuangan dan pengawasan kinerja terhadap fungsi keuangan pada Yayasan Sasmita Jaya universitas Pamulang. Metode yang digunakan dalam penelitian ini adalah kuantitatif yang bersifat deskriptif analisis. Makadilakukan pengujian statistic untuk mengukur seberapa besar pengaruh diantara variabel-variabel yang diteliti dan proses perhitungan statistic. Sedangkan populasi dalam penelitian ini sebanyak 33 dan semuaanggota populasi dijadikan sampel untuk penentuan responden, teknik pengambilan sampel menggunakan sampling jenuh.Pengaruh secara simultan antara Pemahaman Sistem Keuangan (X1) dan Pengawasan Kinerja (X2) TerhadapFungsi Keuangan (Y). Hal ini dibuktikan berdasarkan nilai R Square= 0,249 dapat disimpulkan bahwa, Pemahaman SistemKeuangan (X1) dan Pengawasan Kinerja (X2) TerhadapFungsiKeuangan (Y) sebesar 24,9% dan sisanya 75,1% dipengaruhi oleh faktor lain. Uji hipotesis menunjukkan nilai F hitung 4,982> F tabel3,32 atau probabilitas Sig 0,014< 0,05 maka Ho1 di tolak dan Ha1 di terim artinya signifikan dengan demikian hipotesis yang diajukan menetapkan Terdapat pengaruh secara bersama-sama antara Pemahaman Sistem Keuangan (X1) dan Pengawasan Kinerja (X2) Terhadap Fungsi Keuangan (Y) pada Yayasan Sasmita Jaya Pamulang.

Kata Kunci: Pemahaman Sistem Keuangan, Pengawasan Kinerja, Fungsi Keuangan
Pengaruh Promosi Go-pay Terhadap Keputusan Pengguna Aplikasi Transportasi Online Di Ruang Lingkup Universitas Pamulang
Authors: Febriana Hadijah , Budhiarjo Intan Sari 
Published: February 2021

Research purposes This study aims to determine the effect of go-pay promotion on the decisions of users of online transportation applications within the scope of the University of Pamulang. The research method used is quantitative research methods. The population in this study were students of the 7th semester of the Pamulang University management study program. The sample in this study were 200 respondents in the population. The analytical method used is quantitative analysis. Partially Go-pay promotion variable (x) has a tcount of 11.966 > ttable 1.65259 with a significant value of 0.00, it can be concluded that Go-pay promotion has a positive and significant effect on user decisions. Based on the test results the coefficient of determination (R square) shows the number 0.420 which means that the relationship between Go-pay promotion and user decision is 42%, while the remaining 58% is influenced by other variables not examined in this study. Promotion has a positive and significant effect on Go-pay users' decisions to use online transportation at Pamulang University. This means that the higher and more varied the promotions offered by the company, the greater the chance for users to decide to use online transportation services, especially at Pamulang University.
Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh promosi Go-pay terhadap keputusan pengguna aplikasi transportasi online di ruang lingkup Universitas Pamulang. Metode penelitian yang digunakan adalah metode penelitian kuantitatif. Populasi dalam penelitian ini adalah mahasiswa/mahasiswi semester 7 prodi manajemen Universitas Pamulang. Sampel dalam penelitian ini adalah 200 responden yang terdapat dalam populasi. Metode analisis yang digunakan adalah analisis kuantitatif. Secara parsial promosi Go-pay (x) memiliki thitung sebesar 11,966y > ttabel 1,65259 dengan nilai signifikan 0,00 maka dapat disimpulkan promosi Go-pay berpengaruh positif dan signifikan terhadap keputusan pengguna. Berdasarkan hasil uji koefisien determinasi (R square) menunjukkan angka 0,420 artinya hubungan promosi Go-pay dengan keputusan pengguna sebesar 42%, sedangkan sisanya 58% dipengaruhi oleh variabel lain yang tidak diteliti dalam penelitian ini. Promosi berpengaruh secara positif dan signifikan terhadap keputusan pengguna Go-pay dalam menggunakan trasnportasi online di Universitas Pamulang. Artinya semakin tinggi dan semakin bervariasi promosi yang ditawarkan oleh pihak perusahaan, maka semakin besar peluang pengguna memutuskan untuk menggunakan jasa transportasi online khususnya di Universitas Pamulang.
Kata Kunci : Promosi, Go-Pay, Keputusan Pengguna
LIFE SKILL REMAJA DALAM PENCEGAHAN HIV/AIDS
Authors: Darmawati Irma , Dharmansyah Dhika , Lindayani Linlin , Alfyani Ririn 
Published: February 2021

Latar Belakang: Masa remaja merupakan periode terjadinya pertumbuhan dan perkembangan yang pesat baik secara fisik, psikologis, maupun intelektual. Upaya kecakapan remaja dalam pencegahan HIV/AIDS penting untuk diperhatikan sebab ini dapat menekan laju pertumbuhan HIV/AIDS itu sendiri.Â Tujuan: Penelitian ini bertujuan untuk mengetahui upaya kecakapan hidup (life skill) remaja dalam pencegahan HIV/AIDS. Metode: Penelitian ini merupakan penelitian deskriptif secara kuantitatif menggunakan rancangan cross sectional. Dilakukan dengan subjek penelitian 610 remaja SMK di Bandung yang ditentukan dengan teknik total sampling. Pengumpulan data dengan kuesioner Life Skill Training Questionaire High School dan analisa data dengan distribusi frekuensi. Hasil: Hasil penelitian ini menunjukkan 52% remaja memiliki upaya kecakapan hidup yang baik dengan mean 90.63 Â±10.79. Kesimpulan: Pihak sekolah perlu memberikan pengarahan, informasi, serta edukasi mengenai upaya kecakapan hidup bagi remaja agar memiliki upaya kecakapan hidup yang baik dalam pencegahan HIV/AIDS.
Reverse Transcription Recombinase-Aided Amplification Assay With Lateral Flow Dipstick Assay for Rapid Detection of 2019 Novel Coronavirus
Authors: Zheng Yu-Zhong , Chen Jiang-Tao , Li Jian , Wu Xian-Jing , Wen Jin-Zhou , Liu Xiang-Zhi , Lin Li-Yun , Liang Xue-Yan , Huang Hui-Ying , Zha Guang-Cai , Yang Pei-Kui , Li Lie-Jun , Zhong Tian-Yu , Liu Long , Cheng Wei-Jia , Song Xiao-Nan , Lin Min 
Published: February 2021

BackgroundThe emerging Coronavirus Disease-2019 (COVID-19) has challenged the public health globally. With the increasing requirement of detection for SARS-CoV-2 outside of the laboratory setting, a rapid and precise Point of Care Test (POCT) is urgently needed.MethodsTargeting the nucleocapsid (N) gene of SARS-CoV-2, specific primers, and probes for reverse transcription recombinase-aided amplification coupled with lateral flow dipstick (RT-RAA/LFD) platform were designed. For specificity evaluation, it was tested with human coronaviruses, human influenza A virus, influenza B viruses, respiratory syncytial virus, and hepatitis B virus, respectively. For sensitivity assay, it was estimated by templates of recombinant plasmid and pseudovirus of SARS-CoV-2 RNA. For clinical assessment, 100 clinical samples (13 positive and 87 negatives for SARS-CoV-2) were tested via quantitative reverse transcription PCR (RT-qPCR) and RT-RAA/LFD, respectively.ResultsThe limit of detection was 1 copies/μl in RT-RAA/LFD assay, which could be conducted within 30 min at 39°C, without any cross-reaction with other human coronaviruses and clinical respiratory pathogens. Compared with RT-qPCR, the established POCT assay offered 100% specificity and 100% sensitivity in the detection of clinical samples.ConclusionThis work provides a convenient POCT tool for rapid screening, diagnosis, and monitoring of suspected patients in SARS-CoV-2 endemic areas.
Identification of Potential Biomarkers and Immune Infiltration Characteristics in Idiopathic Pulmonary Arterial Hypertension Using Bioinformatics Analysis
Authors: Zeng Haowei , Liu Xiaoqin , Zhang Yushun 
Published: February 2021

Objectives: Idiopathic pulmonary arterial hypertension (IPAH) is a rare but severe lung disorder, which may lead to heart failure and early mortality. However, little is known about the etiology of IPAH. Thus, the present study aimed to establish the differentially expressed genes (DEGs) between IPAH and normal tissues, which may serve as potential prognostic markers in IPAH. Furthermore, we utilized a versatile computational method, CIBERSORT to identify immune cell infiltration characteristics in IPAH.Materials and Methods: The GSE117261 and GSE48149 datasets were obtained from the Gene Expression Omnibus database. The GSE117261 dataset was adopted to screen DEGs between IPAH and the control groups with the criterion of |log2 fold change| ≥ 1, adjusted P &lt; 0.05, and to further explore their potential biological functions via Gene Ontology analysis, Kyoto Encyclopedia of Genes and Genomes Pathway analysis, and Gene Set Enrichment Analysis. Moreover, the support vector machine (SVM)-recursive feature elimination and the least absolute shrinkage and selection operator regression model were performed jointly to identify the best potential biomarkers. Then we built a regression model based on these selected variables. The GSE48149 dataset was used as a validation cohort to appraise the diagnostic efficacy of the SVM classifier by receiver operating characteristic (ROC) analysis. Finally, immune infiltration was explored by CIBERSORT in IPAH. We further analyzed the correlation between potential biomarkers and immune cells.Results: In total, 75 DEGs were identified; 40 were downregulated, and 35 genes were upregulated. Functional enrichment analysis found a significantly enrichment in heme binding, inflammation, chemokines, cytokine activity, and abnormal glycometabolism. HBB, RNASE2, S100A9, and IL1R2 were identified as the best potential biomarkers with an area under the ROC curve (AUC) of 1 (95%CI = 0.937–1.000, specificity = 100%, sensitivity = 100%) in the discovery cohort and 1(95%CI = 0.805–1.000, specificity = 100%, sensitivity = 100%) in the validation cohort. Moreover, immune infiltration analysis by CIBERSORT showed a higher level of CD8+ T cells, resting memory CD4+ T cells, gamma delta T cells, M1 macrophages, resting mast cells, as well as a lower level of naïve CD4+ T cells, monocytes, M0 macrophages, activated mast cells, and neutrophils in IPAH compared with the control group. In addition, HBB, RNASE2, S100A9, and IL1R2 were correlated with immune cells.Conclusion:HBB, RNASE2, S100A9, and IL1R2 were identified as potential biomarkers to discriminate IPAH from the control. There was an obvious difference in immune infiltration between patient with IPAH and normal groups.
Kallmann Syndrome Due to Heterozygous Mutation in SOX10 Coexisting With Waardenburg Syndrome Type II: Case Report and Review of Literature
Authors: Chen Kan , Wang Haoyu , Lai Yaxin 
Published: February 2021

IntroductionKallmann syndrome (KS) is idiopathic hypogonadotropic hypogonadism with olfactory loss or decline. Waardenburg syndrome type II (WS2) is a clinically and genetically heterogeneous disease, characterized by congenital sensorineural deafness and abnormal pigmentation of the iris, hair, and skin. Recently, mutations in the well-known WS pathogenic gene SOX10 have been found in some KS patients with deafness, but whether SOX10 is a co-pathogenic gene of KS and WS remains uncertain. Here, we report a rare case of KS and WS2 co-occurrence due to SOX10 mutations.MethodsDetailed histories were collected through questionnaires and physical examination. Blood samples of the patient and his family members were collected after obtaining informed consents. Suspected mutations were amplified and verified by Sanger sequencing after the next generation sequencing of related genes. The raw sequence data were compared to the known gene sequence data in publicly available sequence data bases using Burrows-Wheeler Aligner software (BWA, 0.7.12-r1039).ResultsA 28-year-old male patient sought treatment for hypogonadism and the absence of secondary sexual characteristics. In addition, he showed signs of obesity, hyposmia, sensorineural hearing loss, and blue iris. Magnetic resonance imaging (MRI) of the olfactory bulb showed small bilateral olfactory bulbs and tracts and diaphragma cerebri. MRI of the pituitary gland revealed a flat pituitary gland in the sella. Laboratory examination demonstrated hypogonadotropic hypogonadism, pituitary hypothyroidism, subclinical hypothyroidism, and the presence of insulin resistance with normal blood glucose levels. Sequencing of the SOX10 gene showed a 20 bp insertion in between coding bases 1,179 and 1,180 (c.1179_1180insACTATGGCTCAGCCTTCCCC). This results in a frame-shifting mutation of the 394th amino acid serine in exon4 with the resulting the amino acid sequence of the protein predicted to be TMAQPSP PSPAPSLTTL TISPQDPIMA TRARPLASTR PSPIWGPRSG PSTRPSLTPA PQGPSPTAPH TGSSQYIRHC PGPKGGPVAT TPRPAPAPSL CALFLAHLRP GGGSGGG*.ConclusionSOX10 plays an important role in some critical stages of neural crest cell development and SOX10 mutation may be a common pathogenic factor for both KS and WS. Therefore, SOX10 mutation analysis should be considered for KS patients with combined WS clinical manifestations, especially deafness.
A Selective α7 Nicotinic Acetylcholine Receptor Agonist, PNU-282987, Attenuates ILC2s Activation and Alternaria-Induced Airway Inflammation
Authors: Yuan Fang , Jiang Lili , Li Qianyang , Sokulsky Leon , Wanyan Yuanyuan , Wang Lingli , Liu Xiaojie , Zhou Lujia , Tay Hock L. , Zhang Guojun , Yang Ming , Li Fuguang 
Published: February 2021

BackgroundThe anti-inflammatory effect of an α7nAChR agonist, PNU-282987, has previously been explored in the context of inflammatory disease. However, the effects of PNU-282987 on type 2 innate lymphoid cells (ILC2s)-mediated allergic airway inflammation has not yet been established.AimsTo determine the effects of PNU-282987 on the function of ILC2s in the context of IL-33– or Alternaria Alternata (AA)– induced airway inflammation.MethodsPNU-282987 was administered to mice that received recombinant IL-33 or AA intranasal challenges. Lung histological analysis and flow cytometry were performed to determine airway inflammation and the infiltration and activation of ILC2s. The previously published α7nAChR agonist GTS-21 was employed as a comparable reagent. ILC2s were isolated from murine lung tissue and cultured in vitro in the presence of IL-33, IL-2, and IL-7 with/without either PNU-282987 or GTS-21. The expression of the transcription factors GATA3, IKK, and NF-κB were also determined.ResultsPNU-282987 and GTS-21 significantly reduced goblet cell hyperplasia in the airway, eosinophil infiltration, and ILC2s numbers in BALF, following IL-33 or AA challenge. In vitro IL-33 stimulation of isolated lung ILC2s showed a reduction of GATA3 and Ki67 in response to PNU-282987 or GTS-21 treatments. There was a significant reduction in IKK and NF-κB phosphorylation in the PNU-282987–treated group when compared to the GTS-21–treated ILC2s.ConclusionPNU-282987 inhibits ILC2-associated airway inflammation, where its effects were comparable to that of GTS-21.