bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of bioresin composites created with five different vegetable oils such as soybean oil, palm oil, rapeseed oil, cottonseed oil, linseed oil in the automotive industry
Authors: Karacor Berkay , Ozcanli Mustafa 
Published: December 2024

AbstractIn this study, novel bioresin was prepared together with epoxy resin with five different plant oils such as soybean oil, palm oil, rapeseed oil, cottonseed oil, and flaxseed oil. The samples were formed by adding jute/flax intraply fiber to the bioresin formed by adding these vegetable oils to the epoxy at 10%, 20%, 30%, and 40%. While producing these composites, vacuum assisted resin transfer molding method was preferred. Tensile, flexural, impact test, thermogravimetric and differential scanning calorimetric analysis were applied to samples. Moreover, fiber behavior and delamination of composites were examined by morphological analysis. Tensile test outcomes showed cottonseed oil with 40% oil additive and canola oil with 10% oil addition gave higher strength values to the pure epoxy sample. In the impact test, samples with 20% oil added had an average of 2.7–3.44 times higher absorbed energy. Thermal analysis results indicated 10% and 20% oil addition to epoxy raised the glass transition temperature by an average of 6.65–18.6°C and lowered the decomposition temperatures by 11–24°C. These samples, created by adding vegetable oil to the epoxy without chemical treatment, give the composites considerable elasticity and will be used in areas such as the automotive, construction and aerospace industries.Highlights
Adding plant oil to epoxy creates sustainable and environmentally composite.
The usage of plant oils will reduce dependence on petroleum‐based epoxy.
The use of plant oil will further pave the way for green composites.
Elasticity and energy absorption characteristics of the material are improved.
Elongation percent and glass transition temperature of the material improved.
Multiwalled carbon nanotubes filled pineapple/kenaf hybrid laminated composites structures for electromagnetic interface shielding applications
Authors: Sahu Dhaneshwar Prasad , Das Ramyaranjan , Mohanty Sukesh Chandra 
Published: December 2024

AbstractThe main objective of the present research is to investigate the mechanical and electrical properties of multiwalled carbon nanotube (MWCNTs) filled pineapple and kenaf fiber‐based hybrid laminated composite structures using the hand layup technique. 0, 0.1, 0.2, 0.3, 0.4, and 0.5 wt%. of MWCNTs are incorporated into the proposed composite structures. The incorporation of MWCNTs into the hybrid composite structure increases flexural, tensile and impact strength by 173%, 53%, and 29% respectively. The morphological studies are presented to understand fiber pull‐out, matrix breakage, delamination and debonding phenomena. Further, the addition of MWCNTs into the laminated composites decreased the water absorption properties from 8.3% to 4.3%; however, the density of the composites increased slightly due to a more compact structure. The incorporation of MWCNTs into the laminated composite structure enhances the electrical properties such as dielectric constant and AC conductivity by forming a conductive network. The and of developed composites increased by 3.0 and 6.8 times due to the interfacial polarization. The results from the study demonstrate that incorporating MWCNTS into pineapple and kenaf fiber‐based hybrid laminated composite structures helped to enhance both the mechanical and electrical properties, making it a primary choice for electromagnetic interface shielding applications.Highlights
Laminated composites are fabricated using the hand layup technique.
, and of the composites are increased by 173%, 56%, and 29%.
The water absorption percentage decreased from 8.3% to 4.3%.
and of composites increased by 3.04 and 6.8 times.
Exploring the druggability of the UEV domain of human TSG101 in search for broad‐spectrum antivirals
Authors: Montero Fernando , Parra‐López Marisa , Rodríguez‐Martínez Alejandro , Murciano‐Calles Javier , Buzon Pedro , Han Ziying , Lin L.‐Y. , Ramos Maria C. , Ruiz‐Sanz Javier , Martinez Jose C. , Radi Marco , Moog Christiane , Diederich Sandra , Harty Ronald N. , Pérez‐Sánchez Horacio , Vicente Francisca , Castillo Francisco , Luque Irene 
Published: December 2024

AbstractThe ubiquitin E2 variant domain of TSG101 (TSG101‐UEV) plays a pivotal role in protein sorting and virus budding by recognizing PTAP motifs within ubiquitinated proteins. Disruption of TSG101‐UEV/PTAP interactions has emerged as a promising strategy for the development of host‐oriented broad‐spectrum antivirals with low susceptibility to resistance. TSG101 is a challenging target characterized by an extended and flat binding interface, low affinity for PTAP ligands, and complex binding energetics. Here, we assess the druggability of the TSG101‐UEV/PTAP binding interface by searching for drug‐like inhibitors and evaluating their ability to block PTAP recognition, impair budding, and inhibit viral proliferation. A discovery workflow was established by combining in vitro miniaturized HTS assays and a set of cell‐based activity assays including high‐content bimolecular complementation, virus‐like particle release measurement, and antiviral testing in live virus infection. This approach has allowed us to identify a set of chemically diverse molecules that block TSG101‐UEV/PTAP binding with IC50s in the low μM range and are able to disrupt the interaction between full‐length TSG101 and viral proteins in human cells and inhibit viral replication. State‐of‐the‐art molecular docking studies reveal that the active compounds exploit binding hotspots at the PTAP binding site, unlocking the full binding potential of the TSG101‐UEV binding pockets. These inhibitors represent promising hits for the development of novel broad‐spectrum antivirals through targeted optimization and are also valuable tools for investigating the involvement of ESCRT in the proliferation of different virus families and study the secondary effects induced by the disruption of ESCRT/virus interactions.
Cryo‐EM Structure of Human Hyaluronidase PH‐20
Authors: Im Seong‐Bin , Song Hyung Nam , Jeong Tae‐Kyeong , Kim Nayun , Kim Kyuwan , Park Soon‐Jae , Oh Byung‐Ha 
Published: December 2024

ABSTRACTPH‐20 is a specific type of hyaluronidase that plays a critical role in the fertilization process by facilitating the initial binding of sperm to the glycoprotein layer surrounding the oocyte and subsequently breaking down hyaluronic acid polymers in the cumulus cell layer. PH‐20 contains an epidermal growth factor (EGF)‐like domain, which may be involved in the recognition of the glycoprotein layer in addition to the catalytic domain. Herein, we report the structure of human PH‐20 determined by cryogenic electron microscopy. Comparative analyses of the PH‐20 structure with two other available hyaluronidase structures reveal a general similarity in the central catalytic domains, including the conservation of catalytically essential residues at the equivalent spatial positions. However, unique difference is found in the EGF‐like domain, characterized by a longer sequence that is likely to form a flexibly anchored β‐hairpin containing a disulfide bond.
Mechanistic Learning for Predicting Survival Outcomes in Head and Neck Squamous Cell Carcinoma
Authors: Atsou Kevin , Auperin Anne , Guigay Jôel , Salas Sébastien , Benzekry Sebastien 
Published: December 2024

ABSTRACTWe employed a mechanistic learning approach, integrating on‐treatment tumor kinetics (TK) modeling with various machine learning (ML) models to address the challenge of predicting post‐progression survival (PPS)—the duration from the time of documented disease progression to death—and overall survival (OS) in Head and Neck Squamous Cell Carcinoma (HNSCC). We compared the predictive power of model‐derived TK parameters versus RECIST and assessed the efficacy of nine TK‐OS ML models against conventional survival models. Data from 526 advanced HNSCC patients treated with chemotherapy and cetuximab in the TPExtreme trial were analyzed using a double‐exponential model. TK parameters from the first line and maintenance (TKL1) or after four cycles (TK4) were used to predict PPS and post‐cycle 4 OS (OS4), combined with 12 baseline parameters. While ML algorithms underperformed compared to the Cox model for PPS, a random survival forest was superior for OS prediction using TK4 and surpassed RECIST‐based metrics. This model demonstrated unbiased OS4 prediction, suggesting its potential for improving HNSCC treatment evaluation.Trial Registration: ClinicalTrials.gov identifier: NCT02268695.
Detection of Cracks in Ancient Wooden Buildings Based on RPA Oblique Photography Measurement and TLS
Authors: Ma Jian , Liu Dechao , Yan Weidong , Wang Jingli , Liu Guoqi 
Published: December 2024

ABSTRACTAncient architecture embodies the culmination of historical building techniques and artistic expression, representing a valuable heritage of history, art, and technology. These buildings not only document the cultural traditions and architectural evolution of a nation but also preserve significant aspects of human civilization. However, over time, ancient buildings gradually deteriorate due to both natural and human factors. The issue of cracks is particularly critical in the preservation of ancient buildings. Cracks not only affect the esthetic appeal of these structures, but also, if left unaddressed, they can lead to irreversible damage. Existing technologies struggle to address both the marking of defect locations and the calculation of defect information. For example, image recognition technology can identify cracks in a photo, but it is unable to determine the specific location of the crack within the building, nor can it calculate the three‐dimensional information of the crack. To address this, we combined point cloud technology with crack detection algorithms to develop a novel method. First, we integrated point cloud data acquired from terrestrial laser scanning (TLS) and supplementary remotely piloted aircraft (RPA) data to construct a comprehensive point cloud model of the building for archiving. Next, we conduct point cloud density analysis on the model to extract crack regions based on density variations and then analyze these regions to determine crack locations and compute detailed information. To validate this method, we conducted experiments on a 600‐year‐old wooden building on our campus as a case study. The experimental results indicate that this method can accurately determine the specific location of cracks, with the calculated three‐dimensional information corresponding to their actual positions. This method has also proven to be reliable for continuous annual monitoring, allowing for the ongoing detection and analysis of changes in cracks over time.
Mapping Turbidity Spatial Distribution of Monobe River in Kochi, Japan, Using Satellite Images and Existing Turbidity Data
Authors: Hashimoto Naoyuki , Matsuoka Yuya , Niimi Shoko 
Published: December 2024

ABSTRACTMaintaining the environment and functionality of rivers is crucial for the natural environment and socioeconomic activities. In Kochi Prefecture, field measurements of turbidity have been conducted to contribute to countermeasures against prolonged turbid water in the Monobe River; however, a detailed understanding of turbidity across the river has not yet been achieved. Therefore, we attempted to propose a simple turbidity estimation equation based on satellite remote sensing using existing data and visualized the spatial distribution of turbidity in the Monobe River. For turbidity of over 50 FTU, the mean absolute error and mean absolute percentage error (MAPE) of the proposed turbidity estimation equation were 9.9 FTU and 8%, respectively, showing higher accuracy than previous studies, while the accuracy in turbidity of under 50 FTU was not improved for practical use (MAPE was over 49%). By applying the turbidity estimation equation to satellite images, the spatial distribution of turbidity was visualized from the estuary of the Monobe River upstream to the Nagase Dam. The results were consistent with known findings on turbidity dynamics, such as decreasing turbidity in a straight section and increasing it in a curved section, and the spatial distribution of turbidity was considered to be reasonably estimated. The visualization also revealed cases in which turbidity fluctuated greatly in sections where field measurements were not conducted (e.g., increases or decreases in turbidity due to river morphology). In the future, it is expected that the turbidity estimation based on satellite remote sensing will be used in combination with the conventional field measurement of turbidity to understand and analyze the detailed situation of turbidity occurrence in the Monobe River.
Transdermal Film Loaded with Curcuma longa‐Derived Selenium Nanoparticles: Molecular Docking, Ex Vivo Permeability, and Acute Toxicity Study
Authors: Gaikwad Shubhangee , Bansode Amol , Panchal Arati , Choudhari Vishnu 
Published: December 2024

AbstractSe NPs were synthesized using a heating and stirring process involving Curcuma longa extract and selenious acid. Characterization revealed UV–vis absorption at 269 nm, FTIR peaks at 3440 cm−1 (phenolic OH group), 3387 cm−1 (C═O), 2873.42 cm−1 (aromatic ring CH), and 904 cm−1 (Se═O). The average particle size was 27.60 nm with a polydispersity index of 0.38. Scanning electron microscopy displayed irregular square morphology at 50 µm. Inductive couple spectroscopy yielded an 8.84% selenium content. Molecular docking exhibited promising antibacterial (−10.6 kcal/mol) and antifungal (−10.06 kcal/mol) activities compared to standard ciprofloxacin. There was an increase in the zone of inhibition for Streptococcus aureus (16–12 mm), Bacillus subtilis (21–15 mm), Escherichia coli (18.6–14 mm), and Candida albicans (16–10.6 mm). Transdermal films incorporating Se NPs were optimized using the Box–Behnken design, with desirable drug content (95.93%), excellent folding endurance (240), film thickness (0.325 mm), and moisture content (3.39% w/w). In vitro and ex vivo drug release analyses demonstrated efficient delivery: 24.35% (5 h) for in vitro and 18.76% (5 h) for ex vivo, outperforming the marketed formulation (43.75% in vitro, 26.501% ex vivo release). This study highlights the potential of green‐synthesized Se NPs from C. longa in transdermal drug delivery systems, offering enhanced therapeutic efficacy and sustainability.
CeO2–Mn3O4 Solid Solutions With Enhanced Photocatalytic Activity Toward Degradation of Phenolic Compounds
Authors: Pradhan Pulak , Mukherjee Deboshree , Laha Sourav , Chakrabarty Jitamanyu 
Published: December 2024

AbstractIn the present study, Mn3O4, CeO2, and their two solid solutions (10Ce–Mn3O4 and 10Mn–CeO2), synthesized by means of coprecipitation method, are investigated for UV light driven photocatalytic degradation of phenolic compounds. The two substituted nanocatalysts, 10Ce–Mn3O4 and 10Mn–CeO2, possess higher surface area, reduced bandgap, and distorted coordination environments compared to bare Mn3O4 and CeO2, respectively, as indicated by Rietveld refinement of PXRD data, BET, UV, and Raman analysis. 10Ce–Mn3O4 shows the best catalytic activity toward phenol degradation, which has been optimized to achieve promising performance of about 89.3% phenol degradation in 7 h UV irradiation at pH 3, 0.27 g L−1 catalyst dosage, and 25 ppm initial phenol concentration. Density of state (DOS) calculations support the observed catalytic activity trends, which show that on hetero atom substitution, bandgaps of 10Ce–Mn3O4 and 10Mn–CeO2 reduce owing to the incorporation of new energy level at the interband region. 10Ce–Mn3O4 exhibits promising activity retention up to fifth recycle. 10Ce–Mn3O4 is also tested for photodegradation 2,4‐dichlorophenol (2,4‐DCP), which shows very high degradation efficiency of 97.5%. Thus, this study points out a promising photocatalytic efficiency of 10Ce–Mn3O4 toward the degradation of organic pollutants present in wastewater.
Polylactic acid/calcium citrate composite: Preparation, characterization and application for delivery of calcium ions
Authors: Vo‐An Quan , Pham Thi Ly , Nguyen Tuan Anh , Truong Thi Nam , Nguyen Thuy Chinh , Nguyen Dinh Truong , Nguyen Tran Dinh , Nguyen Xuan Hoan 
Published: December 2024

AbstractThis work aims to fabricate a biocompatible film for the slow‐release of minerals (calcium) in biomedical applications. Polylactic acid (PLA) was combined with calcium citrate (CC) at different weight ratios of PLA:CC, such as 10:0, 9:1, 8:2, 7:3, 6:4, and 5:5. Their chemical composition, thermal properties and morphology were evaluated and analyzed by FTIR, DSC, TGA and SEM. The results showed that PLA polymer matrices contained a porous structure, and CC was dispersed in their pores. Thermal analysis revealed increased thermal stability and crystallinity of composite PLA/CC with increasing CC content, suggesting interactions. The release of CC from composite film in neutral media followed two stages: (i) a rapid release stage in the first 2.5–3 h, followed by a stable release stage. The weight loss of PLA occurred rapidly in the first two days and then turned to a stable stage from 2 days onwards. The PC5 with a ratio of PLA/CC of 50:50 samples exhibited the highest initial release in comparison with others. The release mechanism of calcium ions from PLA/CC composite followed the Korsmeyer–Peppas kinetic model. These are the preliminary findings for further studies on the release rate of CC and the effect of CC on the role of PLA in different therapeutic applications.
Molecular docking and ADMET studies of Dillenia philippinensis Rolfe (Dilleniaceae) plant compounds as anti‐inflammatory agents in prostanoid and NF‐kB pathways
Authors: Paulin John P. , Ha Jeongeun , Salen Alyana Yanni P. , Sarmiento Erica Nicole A. , Sioson Joseph Michael G. , Santiago Librado A. 
Published: December 2024

AbstractThe anti‐inflammatory properties of reported compounds from Dillenia philippinensis, also known as katmon, were determined based on their affinity to IRAK‐4, NIK, PLA2, and COX‐2 via molecular docking to determine their capability to block the active site through binding. The binding affinity of the compounds was determined through molecular docking using Autodock Vina. The physiochemical and pharmacokinetic properties were determined using ADMETlab 2.0. Key findings show that tiliroside exhibited the highest binding affinity with COX‐2, PLA2, IRAK‐4, and NIK. Moreover, both tiliroside and the potent inhibitors for each enzyme were found to commonly interact through hydrogen‐bonding and hydrophobic interactions with amino acid residues Val335, Tyr341, Arg499, and Val509 in COX‐2; Ala18, Leu22, His47 in PLA2; Ala211, Val246, Tyr262, Met265, Arg273, and Leu318 in IRAK‐4; Leu406 in NIK. Based on ADMET profiling, they possess moderate to excellent absorption and metabolism and low toxicity despite their low clearance and poor distribution. Betulinic and maslinic acid were found to possess acceptable oral bioavailability according to Lipinski's Rule of Five. Investigation of the binding affinity and druglikeness of the compounds revealed their anti‐inflammatory potential as natural therapeutics. Further experimental studies should be conducted to validate their potency and the initial in silico screening results.
Recycling studies of used engine air filters in the oil leak removal from salt‐water
Authors: Mahmoud Mohamed A. , Maafa Ibrahim M. , Gubari Mohammed Qader , Bakather Omer Y. , Eldoma Mubarak A. , Hassan Mohamed 
Published: December 2024

AbstractThis research proposes a practical method for repurposing used car air filters as an oil‐absorbing material for saltwater. The maximum oil removal rate obtained was 99.75% with 3.325 g/g oil absorption capacity. It required 2.5 min of exposure at a sorbent dose of 0.3 g and room temperature (28 °C) to achieve this level of effectiveness. With an R‐squared value of 0.9796, the Redlich–Peterson model (χ2: 0.0308 and β = 1.1325) was discovered to be the isotherm that fit the data the best. This implies that an oil monolayer is in touch with the utilized filters' surface. With an R‐squared of 0.9855 and χ2 (0.0200), the pseudo‐first‐order kinetic model obtainable the greatest fit. This suggests that the physical sorption mechanism is driving the process. Studies on thermodynamics suggested that the process of absorbing oil was exothermic (∆H: ‒157.209 KJ/mol). According to the reusability study, used car air filters can be recycled up to 5 times, which indicates their potential economic significance.
Mesh Load Factor Uncertainty Analysis in a 5‐MW Wind Turbine Planetary Gearbox Affected by Inherent Manufacturing Errors
Authors: Sanchez‐Espiga J. , Diez‐Ibarbia A. , Fernandez‐del‐Rincon A. , Iglesias M. , Viadero Fernando 
Published: December 2024

ABSTRACTThe current work focuses on the study of the uncertainty related to the manufacturing process of gears for 5‐MW planetary transmissions aimed to the wind generator industry. With this objective, the Monte Carlo method is the employed tool to analyse the influence that selected manufacturing errors have in the performance of these planetary transmissions, more precisely in its mesh load factor. In more detail, the selected manufacturing errors are tangential pinhole position and tooth thickness errors, following the tolerances set by the DIN 3967. This study provides the probability distributions of mesh load factor values related to the size of the manufacturing errors in the transmission. Moreover, both kinds of errors are included together in numerous different planetary transmissions, and the probability distribution functions are also obtained for these. The results lead to relevant conclusions related to the influence of these errors in the performance of these transmissions and their durability and cost‐effectiveness.
Southern flying squirrel use of forests managed for red‐cockaded woodpeckers in East‐Central Mississippi
Authors: Meyer Robert T. , Rush Scott A. , Wang Guiming 
Published: December 2024

AbstractSouthern flying squirrels (Glaucomys volans) occupy and destroy the nests of the endangered red‐cockaded woodpecker (RCW; Dryobates borealis), yet few studies have assessed habitat use within and outside of forest partitions managed for RCW cavities (“cluster partition”). We estimated flying squirrel densities of 0.23 squirrels/ha (95% CI: 0.21–0.26). Little to no evidence of differences was found between flying squirrel home range sizes nor the relative importance value of mast trees within home ranges (P > 0.05) despite vegetation differences between areas inside and outside of cluster partitions (P ≤ 0.01). The lack of evidence may be due to large nightly movements allowing home ranges to overlap cluster partitions and surrounding hardwood habitats. Future management efforts to reduce flying squirrel and RCW interactions should consider multiple strategies including hardwood reduction near cluster partitions and cavity supplementation.