bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative proteomic analysis of vancomycin-sensitive and vancomycin-intermediate resistant S. aureus
Authors: Xu Jia , Han Xin Jun , Yang Ya Li , Peng Pei Lan , Hou Yong Zhi , Yu Zhao , Han Pei Ru , Hu Jian , Ma Xiao Xue 
Published: August 2021

AbstractThe extensive use of vancomycin has led to the development of MRSA (methicillin-resistant Staphylococcus aureus) strains with varying degrees of resistance to vancomycin. Accumulation of surplus cell wall material, decreased cross-linking of peptidoglycan, and/ or other cell wall alterations has been put forward to explain the VISA phenotype. To our knowledge, the protein profiles of hVISA and VISA strains are rarely analyzed via quantitative comparative proteomics. In this study, we subjected subcellular fractions isolated from two isogenic S. aureus strains (vancomycin-intermediate resistant S. aureus) to proteomic analysis, using an integrated quantitative proteomic approach assisted by bioinformatic analysis. In total,128 up-regulated proteins (mainly AhpC, Adh, ArgF et al.) were identified,21 down-regulated proteins (mainly LtaS, SdrD, MsrR, MsrB, OatA et al.) were obtained. The largest group of differentially expressed proteins is composed of enzymic proteins associated with metabolic and catalytic activity, which accounts for 50% and 51% of the total proteins, respectively.Some proteins which take an indispensable part in the regulatory networks of S. aureus with vancomycin treatment are related to Cell wall metabolism ( MurA ), Cell adhesion ( SdrC, SdrD, ClfA, ClfB ), Proteolysis ( Atl, LytM, SceD ) and Pressure response ( MsrA, MsrB, AhpC ) process.In conclusion, our proteomic study revealed regulatory proteins associated with vancomycin resistance in S. aureus, and some of these proteins are involved in the regulation of cell metabolism and function, providing protential targets for further development of drug resistance strategies.
A simulation of the thermal environment of a plastic body of a new type of launch vehicle at the atmospheric phase of the trajectory
Authors: Dreus Andrii , Yemets Vitaly , Dron Mykola , Yemets Mykhailo , Golubek Aleksandr 
Published: August 2021

Purpose
Leading developers and providers in the modern space launch market note a splash in the development of ultralight launch vehicle (LV), driven by the growing demand for small satellites for large constellations in low Earth orbits. One of the promising ways to solve the problem of the quick launch of such satellites is to use a new type of ultralight launch vehicle with a plastic body. The project of such a launch vehicle was proposed by Oles Honchar Dnipro National University (Ukraine). Along with that, there is a need for appropriate research studies on the thermal resistance of the plastic shell, as the physical, mechanical and thermophysical characteristics of polymers significantly differ from traditional aerospace materials. The purpose of this study is to validate the design and ballistic parameters of such a launch vehicle in terms of providing an acceptable thermal environment at the atmospheric phase of the trajectory.

Design/methodology/approach
The workability of a new type of propulsion system is being investigated experimentally in bench conditions. To study the process of aerodynamic heating of a plastic shell, numerical modeling based on the integration of the flight dynamics and heat transfer equations is used.

Findings
Brief information about the design of a new type of ultra-light autophage launch vehicle with a plastic body is presented. A mathematical model for the movement of the launch vehicle at the atmospheric phase of the trajectory, and for the heating of the polyethylene body of the launch vehicle, taking into account the dynamic change in the atmospheric parameters is proposed. The influence of the motion trajectory on the thermal environment of the rocket body is investigated, rational motion trajectories and corresponding permissible g-loads are determined.

Originality/value
The fundamental possibility of using plastic (polyethylene) as a structural material and fuel for bodies of a new type of ultralight launch vehicles has been substantiated. It is shown that to ensure acceptable thermal conditions of a plastic body, it is necessary to use thermal insulation. It is proposed to use a polymeric Teflon coating as such thermal insulation. The results are important for the development of technologies for launching small satellites into orbit, as the use of plastic as the main structural material of the rocket body will significantly reduce the launch cost.
How do search-based and experience-based information matter in the evaluation of user satisfaction? The case of TripAdvisor
Authors: Liu Wuqiang , Shih Hung-Pin 
Published: August 2021

PurposeIn the context of multi-sided platforms (MSPs), the authors address the evaluation of search- and experience-based information and the effect on different components of user satisfaction.Design/methodology/approachThe instrument was developed by either modifying previous measures or developing new scales. The authors collected the sample of experienced 300 TripAdvisor users via online questionnaire survey of a customer panel. The structural equation modeling (SEM) package (AMOS) with the maximum likelihood estimation method was used to test the sample data.FindingsAttitudes toward search-based information can foster user satisfaction with information interaction rather than user satisfaction with social interaction. Attitudes toward experience-based information can foster user satisfaction with information interaction and user satisfaction with social interaction. The motivation for information interaction is stronger than the motivation for social interaction to enhance user satisfaction with information quality.Research limitations/implicationsThe distinction between search- and experience-based information provides different route messages to develop the attitude-driven framework of platform-enabled interactions.Practical implicationsThe support for platform-enabled interactions to enhance the motivation for information and social interactions should be aligned with the evaluation of information quality.Originality/valueThe satisfaction-driven framework has been widely used to examine the post-adoption of information technologies (IT). In contrast, the attitude-driven framework was less examined in the literature. The authors develop a research model based on the attitude-driven framework to examine the platform-enabled interactions that can foster repeated intention.
Reduction of power loss by Henry's law-based soluble gas, mobula alfredi and balanced condition optimization algorithms
Authors: Kanagasabai Lenin 
Published: August 2021

Purpose
Purpose of this paper are Real power loss reduction, voltage stability enhancement and minimization of Voltage deviation.

Design/methodology/approach
In HLG approach as per Henry gas law sum of gas dissolved in the liquid is directly proportional to the partial pressure on above the liquid. Gas dissolving in the liquid which based on Henry gas law is main concept to formulate the proposed algorithm. Populations are divided into groups and all the groups possess the similar Henry constant value. Exploration and exploitation has been balanced effectively. Ranking and position of the worst agents is done in order to avoid the local optima. Then in this work Mobula alfredi optimization (MAO) algorithm is projected to solve optimal reactive power problem. Foraging actions of Mobula alfredi has been imitated to design the algorithm. String foraging, twister foraging and backward roll foraging are mathematically formulated to solve the problem. In the entire exploration space the Mobula alfredi has been forced to discover new regions by assigning capricious position. Through this approach, exploration competence of the algorithm has been improved. In all iterations, the position of the Mobula alfredi has been updated and replaced with the most excellent solution found so far. Exploration and exploitation capabilities have been maintained sequentially. Then in this work balanced condition algorithm (BCA) is projected to solve optimal reactive power problem. Proposed BCA approach based on the conception in physics- on the subject of the mass; incoming, exit and producing in the control volume. Preliminary population has been created based on the dimensions and number of particles and it initialized capriciously in the exploration space with minimum and maximum concentration. Production control parameter and Production probability utilized to control the exploration and exploitation.

Findings
Proposed Henry's Law based -soluble gas optimization (HLG) algorithm, Mobula alfredi optimization (MAO) algorithm and BCA are evaluated in IEEE 30 bus system with L-index (Voltage stability) and also tested in standard IEEE 14, 30, 57, 118, 300 bus test systems without L- index. Real power loss minimization, voltage deviation minimization, and voltage stability index enhancement has been attained.

Originality/value
For the first time Henry's Law based -soluble gas optimization (HLG) algorithm, Mobula alfredi optimization (MAO) algorithm and BCA is projected to solve the power loss reduction problem.
Is a new office a blessing in disguise? The strategic importance of relocation
Authors: Tuomala Essi , Danivska Vitalija , Gustafsson Robin 
Published: August 2021

Purpose
Corporate relocation is a rare event in the history of an individual company. The choices related to location, building and workplace constitute major long-term strategic decisions that determine the company’s future operating environment. However, business decision-makers often do not evaluate all the aspects of relocation before making relocation decisions. Thus, the purpose of this paper is to systemise the knowledge behind corporate relocation and the strategic qualities and impacts of these choices.

Design/methodology/approach
This conceptual paper is based on a comprehensive literature review of 74 articles on the strategic qualities of short-distance corporate relocation of knowledge-intensive firms. Based on the review insights, a conceptual model of the strategic operational qualities for work environment selection is developed.

Findings
This paper identifies three strategic layers of physical environment change, namely, location, building and physical work environment, which need to be considered when deciding to relocate. Corporate relocation affects a company through five operational qualities, namely, staff productivity, costs, employee retention and availability, operational changes and organisational culture.

Practical implications
Relocation is a complex process for an individual company. Justifying choices based on direct costs can lead to unexpected changes in indirect costs for the company. This paper helps decision-makers understand the strategic importance of corporate relocation, identify relocation goals and plan successful relocation.

Originality/value
This paper uses a strategy and organisation lens to provide a systematic overview and synthesis of the strategic qualities of short-distance corporate relocation of knowledge-intensive firms.
Effects of activity-based workspaces on employee belongingness
Authors: Gao Shang , Low Sui Pheng , Gong Hua Qian 
Published: August 2021

PurposeThe purpose of this study is to investigate the effects of the activity-based workspace (ABW) on employee belonging. Place attachment theory (PAT) is used as a proxy to understand and measure the belongingness of employees to their physical workplaces.Design/methodology/approachA case study of a bank’s newly retrofitted ABW office is conducted, providing fresh perspectives on the effect of ABW on employee belonging. A questionnaire survey was used to understand employee belongingness. Surveys are conducted with employees of the bank (n = 100) who experienced the transition from the conventional open-plan office with designated seats to an ABW, to understand and compare the change in employee belonging after the transition, by studying the level of belonging achieved in the space before and after.FindingsThe results showed that there was a positive sense of belongingness amongst employees working in the ABW space, as per the PAT framework and an increased sense of belongingness compared with the previous conventional open-plan office. However, ABWs were found to also have a negative effect on employees’ sense of control and security.Originality/valueMaslow’s hierarchy of needs indicates that a feeling of belonging is fundamental to humans. The need for belonging is also applicable in the workplaces of today’s progressive corporate organisations, where there is increased pressure and incentive to appeal to and retain talent. This research was conducted in response to the huge growth in interest in activity-based working across the corporate real estate community. As there has been no prior research done in the area of the emotional need for belongingness in ABW.
Stakeholders’ perceptions of book piracy’s benefits to society in Lithuania
Authors: Grigas Vincas , Gudinavičius Arūnas 
Published: August 2021

PurposeBook piracy represents a threat to the publishing industry, while for the society, book piracy provides some benefits. The purpose of this study is to examine views of readers, authors and publishers in Lithuania on book piracy’s benefits to society.Design/methodology/approachThis study uses phenomenography to examine readers’, authors’ and publishers’ reflections on book piracy’s potential social benefits. The authors collected research data via semi-structured, face-to-face interviews with 10 participants from each group (readers, authors and publishers – a total of 30 interviews).FindingsSix qualitatively different categories of attitudes were revealed, namely, that book piracy provides easier and more convenient access to books, helps readers save money, pushes readers to read more, helps for authors to gain more popularity, provides wider access to books and provides consumers with moral satisfaction. The similarities between readers’, authors’ and publishers’ views on benefits of book piracy outweigh the differences.Practical implicationsTheoretical background indicates that stakeholders’ explicitly stated attitudes towards book piracy contribute to their book piracy intentions. This study hopes to help publishers in Lithuania confront the challenge of book piracy and develop effective strategies to attenuate a normative framework with four actionable recommendations to help professionals in the publishing industry to better address book piracy.Originality/valueBook piracy continues to perplex publishers, in part because they lack a clear understanding of the social and psychological underpinnings of book piracy. This study aims to develop such an understanding by filling gap in the literature on book piracy: the lack of work on readers’, authors’ and publishers’ perceptions of book piracy’s individual and social benefits.
The prohibition of speculation in Islamic finance: fairness and framing
Authors: Kanwal Aneeka 
Published: August 2021

PurposeThis paper aims to present a simple behavioural explanation of the prohibition of speculation in Islamic finance.Design/methodology/approachThis paper proposes a theoretical model that describes how investors from low income strata of the society may be prone to make sub-optimal decisions when they compare their outcome from a speculative trading activity to that of the counterparty to the trade and perceive inequity to exist.FindingsWhen individuals from low income strata of the society compare their current situation with the average income of the society, they perceive themselves to be in a loss. This creates a loss frame within which they then evaluate all future outcomes. When such individuals invest in speculative trading activities and incur a loss, they compare their outcome from the trade to that of the counterparty to the trade. As speculative trades are a zero sum game, the counterparty makes an equivalent gain from the trade. Thus, the comparison leads to a perception of inequity. This perception of inequity is aggravated by the loss frame within which the investor is operating. The aggravated inequity aversion may then motivate the investor to make further sub-optimal decisions like repeated speculative trading activities. The Islamic prohibition on speculative trading activities may serve to protect low income investors from entering into such cycles of sub-optimal decisions.Originality/valueThis paper offers a unique explanation of why day trading and short selling may be prohibited in Islamic capital markets.
Word of mouse vs word of influencer? An experimental investigation into the consumers’ preferred source of online information
Authors: Jamil Raja Ahmed , Qayyum Abdul 
Published: August 2021

Purpose
This study aims to compare the effects of YouTube information sources (influencer vs word of mouse) on the consumer purchase decision. This paper extends the information adoption model (IAM) to include information language as a central cue and skepticism toward online information as a moderating factor.

Design/methodology/approach
A between-subjects experiment, 2 (influencer vs word of mouse) × 2 (positive vs negative information), was designed to test hypotheses. A total of 171 consumers participated in the experiment and multigroup structural equations modeling (AMOS 21) was applied.

Findings
The results indicate that consumers perceive argument quality to be more useful when the information comes from word of mouse (WOMS). While information language was deemed more useful when the information source was a YouTube influencer and the information type was positive. The study also found that skepticism toward online information reduced the overall effects, particularly for influencers and positive information.

Research limitations/implications
This study contributes to the theory by identifying and investigating the existing gaps in knowledge. For practitioners, findings speak to the synergetic power of YouTube influencers and WOMS as an effective marketing strategy.

Originality/value
This paper is one of the first to compare the effects of YouTube influencers and consumer comments by using the IAM. It also extends IAM with the inclusion of information language as a central cue and skepticism toward online information as a moderating factor.
Fabricating future bodies: making digital sexualities research matter
Authors: Marston Kate 
Published: August 2021

PurposeThis paper critically examines the development and direction of the Fabricating Future Bodies (FFB) Workshop. Troubling notions of co-production as enacting equality or empowering participants, it draws on feminist posthuman and new materialist concepts to understand it as an eventful process that occurs in unpredictable and shifting affect-laden assemblages.Design/methodology/approachThe FFB Workshop formed part of the final phase of my Economic and Social Research Council (ESRC) funded doctoral study, titled “Exploring young people's digital sexual cultures through creative, visual and arts-based methods”. With additional support from Wales' Doctoral Training Partnership, the workshop provided sixteen young people (aged 11–13 years) from one fieldwork school with the opportunity to work with two professional artists in order to creatively re-animate research findings on the digitally networked body. In a three-hour workshop, participants produced cut-up texts and life-size body fabrics that re-imagined what bodies might do, be and become in the future.FindingsThis paper finds that co-productive practices cannot flatten out the institutional and societal power dynamics operating within schools, highlighting how adult intervention was necessary to hold space for young people to participate. It also observes the agency of the art materials employed in the workshop in enabling young people to articulate what mattered to them about the digitally networked body. While the workshop was limited in its ability to renegotiate institutional and peer power dynamics, it produced rich data that indicated how carefully choreographed arts-based practices offer generative possibilities for digital sexualities research and education.Originality/valueBy employing speculative fiction, cut-up poetry and textiles to explore the digitally networked body, this paper outlines an innovative methodological-pedagogical approach to engaging with young people's digitally networked lives.
Big data-driven supply chain and performance: a resource-based view
Authors: Kamboj Shampy , Rana Shruti 
Published: August 2021

PurposeThe main objective of this paper is to study the role of supply chain performance (SCP) as a mediator between big data-driven supply chain (BDDSC) and firm sustainable performance. In addition, the role of firm age as a moderator between BDDSC and SCP as well as between SCP and firm sustainable performance has also been explored.Design/methodology/approachThe 200 managers of medium or senior level positions in micro, small and medium enterprises (MSMEs) located at Delhi-NCR have been contacted. Further, collected data have been confirmed with confirmatory factor analysis (CFA). In this paper, structure equation modeling (SEM) has been employed to empirically check the proposed hypotheses and their relationships.FindingsThe findings confirmed that SCP mediates the link between BDDSC and firm sustainable performance. Additionally, firm age moderates the association between BDDSC and SCP as well as between SCP and firm sustainable performance.Research limitations/implicationsThe role of SCP and firm age between BDDSC and sustainable performance have been examined in the context of MSMEs in Delhi-NCR and thereby limit the generalization of results to other industries and country contexts.Originality/valueThe present study adds to the existing literature via recognizing the blackbox using SCP and firm age to comprehend BDDSC and firm sustainable performance relationship.
Efficacy and safety profile of sitagliptin, vildagliptin, and metformin in newly diagnosed type 2 diabetic subjects
Authors: Elhini Sahar Hossam , Hussien Amal K. , Omran Ahmed Abd Elsamie , Elsayed Asmaa A. , saeed Haitham 
Published: August 2021

AbstractType 2 diabetes mellitus (T2DM) is a chronic and progressive disease that requires long‐term management. Thus, dipeptidyl peptidase‐4 inhibitors (DPP‐4) need more investigations about their efficacy and safety profile as there is still no evidence of whether DPP‐4 inhibitors can be used as a first line option for T2DM drug‐naïve patients. In this randomized case‐controlled study, 60 drug‐naïve T2DM subjects were randomized into three groups, each group comprising 20 subjects. Group 1 was given sitagliptin 100 mg once daily, Group 2 was given vildagliptin 50 mg twice daily, and Group 3 served as the control group and was given metformin 1 g twice daily. Efficacy endpoints included changes in glycosylated haemoglobin (HbA1c), fasting plasma glucose (FPG), and 2‐hr postprandial plasma glucose (PPG), and the secondary endpoints were related to safety profile were the assessment of liver and kidney function tests and complete blood count (CBC). All treatment regimens had comparable efficacy and safety profiles with the non‐significant relative superiority of vildagliptin in lowering HbA1c more than sitagliptin but significant (p = 0.011) regarding FPG reduction, vildagliptin significantly decreased HbA1c by −1.02% (p < 0.001), sitagliptin significantly decreased HbA1c by −0.96% (p < 0.001), and control significantly decreased HbA1c by −0.90% (p < 0.001) compared with baseline. The studied drugs showed moderate efficacy in lowering HbA1c levels with the non‐significant relative higher efficacy of DPP‐4 inhibitors. DPP‐4 inhibitors and metformin showed favourable effects on improving metabolic syndrome by decreasing blood pressure, serum triglycerides (TG), low‐density lipoprotein (LDL), total cholesterol, and increasing high‐density lipoprotein (HDL), plus their positive impacts on weight. As a final conclusion, the three medications are highly comparable.