bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Hub Genes for Controlling Cancer Stem Cell Characteristics in Colorectal Cancer by Bioinformatics Analysis
Authors: Li Xiang , Huang Shuoyang , Yang Chao , Zheng Yongbin 
Published: August 2021

Abstract
Background

Cancer stem cells (CSCs), which are capable of infinite proliferation and self-renewal, play a crucial role in the occurrence and development of colorectal cancer (CRC). The study of the expression characteristics of CRC stem cell-related genes and their interaction with the immune microenvironment may contribute to CRC treatment.
Results

In order to explore the hub genes that regulate the stemness characteristics of CRC, we obtained gene expression values of the Cancer Genome Atlas (TCGA), stemness indices (mRNAsi), and corresponding survival data from UCSC Xena Browser. Differentially expressed genes (DEGs) were identified in cancer and normal tissues. Then we screened 2 modules and 210 mRNAsi-related genes from 4,941 DEGs by weighted gene co-expression network analysis. A prognostic model including ten genes (VCAN, SPARC, COL12A1, THBS2, COL1A2, COL5A1, TAGLN, DCN, MYH11, CDH11) was constructed using protein interaction networks and LASSO regression. We also evaluated the relationship between cancer stemness and immune response and found there was a strong correlation between each other.
Conclusions

Our study establishes a prognostic model associated with CSCs and reveals the association between mRNAsi and the tumor immune microenvironment, which is useful for the targeted therapy of CRC.
Clinical Study of MAP2K1-Mutated Langerhans Cell Histiocytosis in Children
Authors: Yang Ying , Wang Chanjuan , Wang Dong , Cui Lei , Li Na , Lian Hongyun , Ma Honghao , Zhao Yunze , Zhang Liping , Liu Wei , Wang Yizhuo , Wu Wanshui , Zhang Rui , Li Zhigang , Wang Tianyou 
Published: August 2021

Abstract
Purpose

To analyze the genetic and clinical features of children with MAP2K1-mutated Langerhans cell histiocytosis (LCH).
Methods

We compared the clinical features of 37 children with MAP2K1-mutated LCH with those of the BRAFV600E mutation group (n = 133) and no known mutation group (n = 59) in the same period.
Results

We found 13 mutations of the MAP2K1 gene, which were mainly concentrated at p.53–62 and p.98–103. The most common mutation site was c.172_186del (12/37). Compared with the BRAFV600E mutation group, the patients with MAP2K1 mutations were mainly characterized by single system multiple bone involvement (P = 0.022), with later disease onset (P = 0.029) as well as less involvement of risk organs, especially liver (P = 0.024). There was no significant difference in clinical features compared with the no known mutation group. The 2-year progression-free survival rate of first-line treatment (ChiCTR1900025783, 07/09/2019) in MAP2K1-mutated patients was 65.6% ± 9.5%. The prognosis of patients with lung involvement was poor [HR (95% CI) = 6.312 (1.769–22.526), P = 0.005]. More progression or relapses could be found in patients with bony thorax involvement (8/17 vs. 2/20, P = 0.023), yet involvements in other sites of bones, such as craniofacial bone involvement (8/26 vs. 2/11, P = 0.688) and limb bone involvement (5/12 vs. 5/25, P = 0.240), were not correlated to disease progression or relapse.
Conclusion

The children with MAP2K1-mutated LCH have specific clinical features requiring clinical stratification and precise treatment. MAP2K1-mutated patients with lung involvement (especially with bony thorax involvement) had poor prognosis.
Successful Treatment of Severe Electrolyte Imbalance-Induced Cardiac Arrest Caused by Adrenal Tuberculosis With ECMO in The ED
Authors: Yang Ning , Zhou Liping , Mo Xiaoye , Huang Guoqing , Wu Ping 
Published: August 2021

Abstract
Background Tuberculosis (TB) is a chronic infectious disease, common in China. TB bacteria can invade multiple organs throughout the body, but they rarely cause critical illness. We present a complex critically ill case in this report. Case presentation A 40-year-old man suffered sudden cardiac arrest during an emergency room visit. Spontaneous circulation resumed after emergency cardiopulmonary resuscitation (CPR), but recurrent ventricular fibrillation and refractory cardiac shock emerged. Thereafter, extracorporeal membrane oxygenation (ECMO) was implemented to maintain hemodynamic stability. Blood test results revealed that the patient had severe electrolyte imbalance and adrenal insufficiency. Further imaging examination showed multiple tuberculosis lesions throughout the body, including the lungs, adrenal glands, and lumbar spine. In the end, the patient was successfully moved from the ICU after weaning from ECMO and the ventilator, and then transferred to an infectious disease specialist hospital for standard anti-tuberculosis therapy. Conclusions ECMO has won the opportunity for the diagnosis and treatment of this young patient who suffered from a rare cause of cardiac arrest, and finally achieved a good prognosis.
A Retrospective Study of Percutaneous Endoscopic Interlaminar Discectomy for L5-S1 Calcified Lumbar Disc Herniation
Authors: Cheng Yuanpei , Li Yongbo , Chen Xipeng , Wei Baixing , Jiang Liming , Zhang Jixiang , Tan Zhe , Pi Yangwei , Wu Han 
Published: August 2021

Abstract
Background: Calcified lumbar disc herniation (CLDH) is considered to be a special type of lumbar disc herniation (LDH). Percutaneous endoscopic interlaminar discectomy (PEID), with safety and efficacy, has been proved to be a minimally invasive surgery for LDH. However, there are few studies on PEID in the treatment of CLDH at L5-S1 level. This research aimed to analyze the clinical efficacy of PEID for L5-S1 CLDH.Methods: From August 2016 to April 2020, we retrospectively analyzed 28 consecutive patients (17 males; 11 females) with L5-S1 CLDH treated with PEID at our institution. All the patients were followed up for greater than 1 year postoperatively. The demographic characteristics, surgical results and clinical outcomes estimated by the visual analog scale (VAS) for leg pain, Oswestry disability index (ODI) and modified MacNab criteria were collected.Results: All patients were successfully performed by PEID. The mean operative time and intraoperative blood loss were 65.36 ± 5.26 minutes and 13.21 ± 4.35 ml, respectively. The VAS for leg pain and ODI scores improved remarkably from 7.54 ± 0.96 to 1.50 ± 0.51 (P < 0.05) and from 69.29 ± 9.91 to 17.43 ± 3.69 (P < 0.05) a year after operation, respectively. According to the modified MacNab criteria of the last follow-up, the excellent and good rates are 92.86%. Two of the patients had complications, one had nerve root injury and the other had postoperative dysesthesia.Conclusions: PEID achieved good clinical outcomes in the treatment of L5-S1 CLDH. And PEID was a safe and effective minimally invasive surgery for L5-S1 CLDH.
Elements of Management and Leadership Strengthening in Health Systems: A Qualitative Study From Iran
Authors: Bahreini Rona , Gholizadeh Masumeh , Yousefi Mahmood , Janati Ali 
Published: August 2021

Abstract
Background: Achieving the health-related Millennium Development Goals (MDGs) and improved health services needs management and leadership capacity building. Hence, the aim of this study is to identify the elements of management and leadership capacity.Methods: Semi-structured individual interviews were conducted with 20 health managers. Sampling method was purposive. Data were collected using a researcher-made interview guide. The transcribed text was analyzed using framework analysis.Results: Five main themes emerged from the analysis: (1) competencies required for managers; (2) selection and appointment of managers; (3) establishment of managers' database; (4) deployment of functional support system; and (5) environmental sensitivity. Each of these themes contains sub-themes.Conclusions: Extracting elements of management and leadership capacity helps managers to assess management capacity and leadership comprehensively and effectively. Also, effective and useful operations can be done to strengthen the management and leadership capacity.
An Improved the Fast Iterative Shrinkage Thresholding Algorithm With an Error for Image Deblurring Problem
Authors: Tianchai Pattanapong 
Published: August 2021

Abstract
In this paper, we introduce a new iterative forward-backward splitting method with an error for solving the variational inclusion problem of the sum of two monotone operators in real Hilbert spaces. We suggest and analyze this method under some mild appropriate conditions imposed on the parameters such that another strong convergence theorem for these problem is obtained. We also apply our main result to improved the fast iterative shrinkage thresholding algorithm (IFISTA) with an error for solving the image deblurring problem. Finally, we provide numerical experiments to illustrate the convergence behavior and show the effectiveness of the sequence constructed by the inertial technique to the fast processing with high performance and the fast convergence with good performance of IFISTA.
Bacterial and Viral Coinfection in Idiopathic Pulmonary Fibrosis Patients: the Prevalence and Possible Role in Disease Progression
Authors: Moghoofei Mohsen , Mostafaei Shayan , Kondori Nasim , Armstrong Michelle E. , Babaei Farhad 
Published: August 2021

Abstract
BackgroundIdiopathic pulmonary fibrosis (IPF) is a progressive interstitial pneumonia of unknown etiology with a mean survival rate of less than 3 years. Gap StatementNo previous studies have been performed on the role of co-infection (viral and bacterial infection) in the pathogensis and progression of IPF.AimIn this study, we investigated the role of viral/bacterial infection and coinfection and their possible association with pathogensis and progression of IPF.MethodsWe investigated the prevalence and impact of bacterial and viral coinfection in IPF patients (n = 67) in the context of pulmonary function (FVC, FEV1 and DLCO), disease status and mortality risk. Using principal component analysis (PCA), we also investigated the relationship between and distribution of bacterial and viral co-infection in the IPF cohort.ResultsOf the 67 samples, 17.9% samples were positive for viral infection, 10.4% samples were positive for bacterial infection and 59.7% samples were positive coinfection. We demonstrated that IPF patients who were co-infected had a significantly increased risk of mortality compared (p = 0.031) with IPF patients who were non-infected [Hazard ratio: 8.12; 95% C.I.: 1.3–26.9]. Furthermore, coinfection has also been implicated in disease progression during acute exacerbations in IPF (AE-IPF).ConclusionIn this study, we report for the first time that IPF patients who were coinfected with bacteria and viral infection have significantly decreased FVC and DLCO (% predicted), increased incidence of AE-IPF, increased incidence of death and risk of mortality compared with non-infected IPF patients.
La violencia contra las mujeres como discriminación
Authors: José Añón María 
Published: August 2021

<span lang="ES">Este articulo trata de dar respuesta a las siguientes cuestiones, por qué conceptualizar la violencia contra las mujeres como discriminación y qué concepción sobre la discriminación es idónea para explicar y comprender la violencia contra las mujeres desde el prisma de los derechos humanos El objetivo es reflexionar sobre dos aspectos. En primer lugar, que la discriminación puede tener dos lecturas o puede ser entendida de acuerdo con dos modelos distintos. Sintéticamente, discriminación como ruptura de la igualdad de trato, como trato diferenciado e injusto y discriminación como resultado de una estructura social, como un sistema de subordinación. Segundo que ambas concepciones están presentes, no sin tensiones, en los sistemas de protección jurídica internacional de los derechos humanos. Así examinaré <em>(i)</em> el sistema de protección universal de derechos humanos de Naciones Unidas para mostrar como la violencia sobre las mujeres se inserta en la categoría de discriminación y <em>(ii) </em>el sistema del Consejo de Europa, este último a través de la jurisprudencia del Tribunal Europeo de Derechos Humanos. </span>
O que não pode ser escrito merece ser vivido?
Authors: Araujo Betania Libanio Dantas de 
Published: August 2021

O artigo analisa a importância da Arte na formação do pedagogo, tendo como referência a docência da autora no curso de Pedagogia da Universidade Federal de São Paulo, campus Guarulhos, entre 2011 e 2020. As disciplinas Fundamentos Teórico-práticos do Ensino da Arte e eletivas, as Práticas Pedagógicas Programadas, a Residência Pedagógica e as pesquisas orientadas são momentos sistemáticos desse encontro, que, utilizando o Laboratório de Arte (Labart) como atelier coletivo, promoveu vivências nos fazeres e saberes da arte. Em relação à produção, o resgate das produções individuais e coletivas, a elaboração dos memoriais e a criação do Museu Virtual do Desenho da Criança contribuem para diversos aspectos da formação dos alunos, cujas experiências com as Artes Visuais podem ser sintetizadas em uma espiral poética, na qual interagem a razão intuitiva, a imaginação criadora e intersubjetividade.
DEEP GEOPHYSICAL INVESTIGATIONS IN NORTH CAUCASIAN FEDERAL DISTRICT: PROBLEMS OF DEEP GEOLOGY AND GEOPHYSICS IN REGIONAL INVESTIGATIONS. ABOUT ZONE OF ARDON FAULT
Authors: Заалишвили В.Б. , Невская Н.И. , Невский Л.Н. , Трофименко С.Н. , Шемпелев А.Г. 
Published: August 2021

В работе рассматриваются вопросы глубинного геологического строения территории Осетии и со- предельных с ней площадях. Показана роль ведущих ученых академических и отраслевых учреждений в построении геолого-геофизических разрезов. В основу исследования положены материалы, полученные специалистами бывшего Северо-Кавказ- ского геологического Управления и учеными Центра геофизических исследований, при изучении особен- ностей земной коры в пределах зоны сопряжения Центрального и Восточного Кавказа. Анализ и синтез накопленных материалов позволяет сформулировать некоторые, наиболее общие проблемные вопросы глубинной геологии, в первую очередь те, которые продвигают практические за- дачи прогноза размещения месторождений полезных ископаемых, а также геодинамики эндогенных и экзогенных процессов. С необходимой детальностью приводится описание моделей глубинного строения в зоне предпо- лагаемого Ардонского разлома.
The deep geological structure of the Ossetia territory and adjacent areas is considered. The role of the leading scientists of the academic and branch institutions in the construction of geological and geophysical profiles is shown. The study is based on materials obtained by specialists of the former North Caucasus geological Department and the scientists of the Center of Geophysical Investigations, in studying the characteristics of the earths crust within the zone of conjugation of the Central and East Caucasus. Analysis and synthesis of the accumulated materials allows us to formulate some of the most common issue of Depth Geology, especially those that promote practical problems of the prognosis of mineral deposits and geodynamics of endogenous and exogenous processes
THE INCREMENTS OF GRAVITY MONITORING AT NORTHERN CAUCASUS GRAVIMETRIC TEAM POINTS USING PRECISION RELATIVE GRAVIMETERS
Authors: Милюков В.К. , Юшкин В.Д. , Миронов А.П. , Заалишвили В.Б. , Кануков А.С. , Дзеранов Б.В. 
Published: August 2021

Представлены результаты измерения приращений силы тяжести относительными гравиметрами на семи пунктах Северо-Кавказского региона, образующих опорную гравиметрическую сеть для определе- ния вариаций абсолютных значений силы тяжести и вертикальных движений региона. Для распростране- ния сети на другие участки региона без проведения дорогостоящих абсолютных измерений разработана методика, основанная на измерении приращения силы тяжести между новым и опорным пунктами высо- коточным относительным гравиметром. Апробация методики на двухлетнем интервале наблюдений по- казала ее перспективность, тем не менее, для достоверного определения вертикального движения пункта необходимы наблюдения на более длительном интервале.
Results of relative gravity measurements on seven sites of Northern Caucasus region, which form a reference network for determination of vertical movements of the region by a gravimetric method, are presented. To spread this network to other parts of the region without carrying out expensive absolute measurements, the technique based on measurement of the gravity increment between the new and reference sites by the high-precision relative gravity meter is developed. Two-years observations showed availability of this technique, nevertheless, for reliable determination of the site vertical movements, the observations on longer time interval are necessary
INFORMATIONAL MONITORING OF DISTRIBUTED PHYSICAL FIELDS WITHIN THE URBANIZED TERRITORIES
Authors: Заалишвили В.Б. , Бурдзиева О.Г. , Закс Т.В. , Кануков А.С. 
Published: August 2021

Проведены исследования влияния факторов окружающей среды на здоровье населения на терри- тории г. Владикавказ. Данные анализировались методом медико-экогеофизического районирования по зонам обслуживания населения городскими поликлиниками. В 126 точках города были произведены замеры уровня гамма-излучения, а также проведены замеры величин электрических и магнитных полей
The effect of environmental factors on the health of the population in the city of Vladikavkaz is investigated. Data were analyzed using method of medical-ecological-geophysical zoning in areas covered by urban clinics. Measurements of the gamma-radiation level, and also measurements of the electrical and magnetic field values were made in 126 points of the city
ABOUT SOIL SEISMIC VIBRATIONS SPECTRA IN EARTHQUAKE NEAR ZONE
Authors: Геодакян Э.Г. , Оганесян С.М. , Саргсян С.Н. , Карапетян Дж.К. 
Published: August 2021

Изучение спектральных и динамических параметров очагов землетрясений по данным инженерных макросейсмических и инструментальных наблюдений необходимо для решения многих задач фундамен- тальной и прикладной сейсмологии. Это задачи физики очага, процессов подготовки сильных землетря- сений, задачи сейсмического районирования, микрорайонирования, расчета сейсмических воздействий, геофизической защиты территории и т. д.
Study of spectral and dynamic parameters of earthquake sources with the help of the data of engineering macroseismic and instrumental observations is necessary for many fundamental and applied seismology problems solving. These are the problems of earthquake source physics, processes of strong earthquakes origination, problems of seismic zoning, microzonation, seismic impacts calculation, geophysical protection of territory etc.
GASES IN CONNECTION WITH SEISMIC EVENTS ON THE FASTERN CAUCAUS
Authors: Саидов О.А. 
Published: August 2021

Показано, что в периоды, предшествующие и сопутствующие землетрясениям, величина дисперсии в смежных интервалах временных геохимических рядов изменяется закономерно. В периоды повышения сейсмической активности в зависимости от силы готовящегося землетрясения образуется четкое поле повышенных значений дисперсии.
It is shown that during the periods previous and associated of earthquakes, the dispersion amount in complementari intervals of time geochemical sequence has regular variation. During the periods of seismic activity increase depending on the preparing earthquake intensity the clear field of the dispersion increased values is formed
ANALYTICAL AND NUMERICAL ANALYSIS OF PLANE SEISMIC WAVES IN NONLINEAR VISCOELASTIC MEDIA
Authors: Тотиева Ж.Д. 
Published: August 2021

Представлены модель, алгоритм и программный расчет нелинейного отклика среды на заданное возмущение для двухслойного полупространства. Теоретический подход основан на использовании функции Грина. Проведен анализ зависимости спектров синтетических акселерограмм от параметра нелинейности и частоты входного сигнала. Предложенная модель в полной мере учитывает физическую нелинейность: во‑первых, нелинейную связь «напряжение-деформация», во‑вторых, нелинейное затухание среды в зависимости от уровня деформации. Программный продукт может использоваться при прогнозировании нелинейного отклика грунта на ожидаемое расчетное землетрясение
The model, algorithm and numerical results of the nonlinear response of the medium is presented. The theoretical approach is based on the use of the Green’s function. Analysis of the dependence of the spectra of synthetic accelerograms of the nonlinearity parameter and frequency of the input signal is carried out. The model takes into account the physical nonlinearity: at first, non-linear relationship «stress-strain», secondly, nonlinear damping medium depending on the strain level. The software can be used for predicting the nonlinear response of the ground to the expected estimated earthquake.
ANALYSIS OF SEISMIC REGIME OF THE TEREK-CASPIAN DEPRESSION (TERRITORY OF CHECHEN AND INGUSH REPUBLICS) AND PROBLEM OF STRONG EARTHQUAKES PREDICTION
Authors: Бадаев С.В. 
Published: August 2021

Работа посвящена изучению сейсмичности территорий Чечни и Ингушетии. Сделан анализ литературных источников по истории изучения сейсмичности Кавказа по геолого-геофизическим данным. Пространственно-временного распределения сейсмической активности территорий за период с 1950–2015 гг.
Построены карты эпицентров землетрясений, сейсмической активности А10, график повторяемости, график Беньофа
The work is devoted to the seismicity of Chechnya and Ingushetia territory. The literature references about research of Caucasus seismicity according to geological and geophysical data are analyzed. Spatio-temporal distribution of seismic activity areas for the period 1950–2015 is analyzed. The earthquake epicenter maps, seismic activity A10, recurrence graph, the Benioff graph are constructed.
CATASTROPHIC ICE-STONE INERTIAL GAS-DYNAMIC AVALANCHE-TYPE STREAMS AS AN OCCURRENCE OF PAROXYSMAL AIR-BLAST DIRECTIONAL GAS-DYNAMIC SURGES OF GLACIERS. ABOUT CORRELATION OF THE CONCEPTS «AVALANCHE-TYPE STREAM» AND «MUDFLOW»
Authors: Бергер М.Г. 
Published: August 2021

Рассмотрены особенности катастрофических гляциальных лавинообразных потоков. Выделен особый тип этих потоков, особенности возникновения и движения которых указывают на то, что эти потоки являются проявлениями пароксизмальных взрывоподобных направленных газодинамических выбросов ледников. Дано объяснение механизма и экстраординарных параметров кинематики движения таких потоков. Подчеркнуто принципиальное отличие этих потоков от селей. Соответственно, селевая трактовка Колкинской катастрофы 2002 г. в ее эпицентральной и сопредельной с ней зоне, включающей зону транзита гляциального лавинообразного потока, является необоснованной и ошибочной, с чем согласуется безуспешность предпринятых попыток гидравлического моделирования этой катастрофы. Показано, что эти потоки не относятся к числу склоново-гравитационных, не представляют собой ни обычный, ни особый тип подобных явлений
The features of catastrophic glacial avalanche-type streams are considered in the article. A special type of these streams is singled out. The features of origination and motion of such streams point at the fact that they are the evidence of paroxysmal air-blast directional gas-dynamic surges of glaciers. The mechanism and extraordinary parameters of motion kinematics of these streams are explained. Accordingly a mudflow version of the Kolka catastrophe of 2002 in its epicentral and adjoining zone including the motion zone of glacial avalanche-type stream is unreasonable and false what confirms unsuccessful efforts of hydraulic modelling of this catastrophe. It is shown that such streams are referred to the slope-gravity phenomena and are either ordinary no special type of such phenomena