bluuebunny/crossref_metadata_2025_split huggingface dataset:
"Struggling to Bridge the Intergeneration Gap": Iranian Parents’ approaches to their Adolescent Sons’ Sexual Upbringing-a qualitative study
Authors: Rouhparvar zahra , javadnoori mojgan , Shahali Shadab 
Published: June 2021

Abstract
BackgroundChildren's sexual education has an important role in adolescent sexual health; however sexual upbringing is one of the most challenging dimensions of education for families, especially in Muslim societies experiencing transition to modernity. There is little information about sexuality upbringing for boys in Iran. The present study aimed to explain parents' strategies in the sexual upbringing of adolescent boys in Iran. MethodsThis qualitative study was conducted in 2017 in Ahvaz, Iran. The qualitative data were collected through a purposeful sampling method, with a maximum variation by conducting semi-structured in-depth interviews and focused group discussions with 27 parents from the middle/high social class having 10-19-year-old adolescent sons. Qualitative data were analyzed using conventional qualitative content analysis. ResultsParents' strategies for their sons’ sexuality upbringing emerged in five categories: control, monitoring, and restriction; abstinence as the main content of sexual upbringing; endeavoring for peace and tolerance; Criticizing the pathologic attitude to sexual instinct; and hope for social learning. The theme "Struggling to bridge the inter-generation gap" emerged from the categories. Conclusion Iranian parents are facing uncertainty regarding sexual education for their adolescent boys. All approaches finally resulted in abstinence. Abstinence is the central concept in their sexuality upbringing style for their sons. so, sexual relationship is a red line issue in sexuality upbringing. Their conservative peaceful approach tries to reduce the intergeneration gap.
AQP9 expression and phosphorylation affect arsenic uptake and tolerance in human liver hepatocellular cells
Authors: Chen Rong , Wang Xiaozhen , Wang Qianqian , Hong Yu , Xu Xianrong , Yang Jun , Lian Fuzhi , Cao Yifei 
Published: June 2021

Abstract
Background

Little is known about the signaling mechanisms involved in arsenic tolerance or detoxification, although the water channel protein aquaporin-9 (AQP9) and components of the mitogen-activated protein kinase (MAPK) pathway have putative roles. Elucidation of the mechanisms of resistance in mammalian cells would be helpful in developing effective, arsenic-based therapeutic strategies.
Methods

The association between AQP9 and arsenic accumulation and tolerance was investigated in arsenic-sensitive human liver hepatocellular cells (HepG2) and arsenic-resistant HepG2 (AsHepG2) cells.
Results

The IC50 value for arsenic of AsHepG2 cells (15.59 µM) was significantly higher than that of HepG2 cells (7.33 µM; Ρ < 0.05), and AsHepG2 cells accumulated significantly low levels of arsenic after treatment with sodium arsenite (NaAsO2; Ρ < 0.01). Arsenic accumulation in AsHepG2 cells reached a plateau 6 h after treatment, while in HepG2 cells it continued to increase throughout the experimental period. Additionally, intracellular arsenic accumulation in AQP9-overexpressing AsHepG2 cells significantly increased within 10 h of treatment, whereas in HepG2 cells it increased throughout the experimental period. The level of AQP9 protein in AsHepG2 cells decreased in a concentration-dependent manner, but was not markedly different in HepG2 cells. Furthermore, after NaAsO2 treatment the level of phosphorylated AQP9 and p38 was significantly increased with time in the two cell lines. Partial inhibition of p38 activity by the specific inhibitor SB203580 did not significantly affect AQP9 protein expression or phosphorylation.
Conclusion

AQP9 expression and its state of phosphorylation are closely related to arsenic uptake and may regulate cellular arsenic tolerance by reducing its uptake rate. p38 may have a limited role in the regulation of AQP9 phosphorylation in AsHepG2 cells.
The role of surgical access in retroperitoneal sarcoma resection - a retrospective study
Authors: Aeschbacher Pauline , Kollár Attila , Candinas Daniel , Beldi Guido , Lachenmayer Anja 
Published: June 2021

Abstract
Background
Retroperitoneal sarcoma (RPS) is a rare disease often requiring multi-visceral and wide margin resections. Midline incision seems to be the access of choice. Up to now there is no evidence for the best surgical access. This study aimed to analyze the oncological outcome according to the incision used for the resection.
Methods
All patients treated for RPS between 2007 and 2018 at the Department of Visceral Surgery and Medicine of the University Hospital Bern and receiving a RPS resection in curative intent were included. Patient- and treatment specific factors as well as local recurrence-free survival was analyzed in correlation with the type of surgical access used.
Results
Thirty-five patients were treated for RPS at our center. The majority received their primary RPS resection at a tertiary medical center (n = 23) the rest of the resection were performed in an external non-tertiary institution (n = 12). Median tumor size was 24 cm. Resections were performed via a midline laparotomy (MI = 31) or flank incision (FI = 4). All FI were performed at a non-tertiary center and received no multi-visceral resection. In ML the macroscopically complete resection (R0/1) rate was 83.9% and 25% in FI (p = 0.021). The local recurrence rate after R0/1 resection was 100% in FI and 61.5% in ML (p = 1.00). Early recurrence or local disease progression was present in 50% of FI compared to 0% in ML (p = 0.01). The median recurrence-free survival after R0/1 resection was lower in FI (p < 0.001) and in patients operated in a non-tertiary center (p = 0.27).
Conclusions
FI with limited exposure of the retroperitoneum and no access to the visceral organs as well as resection at a non-tertiary center are associated worse outcome in RPS surgery.
Synchronized Activation of Brain Waves by Singing Bowl Beating Sounds
Authors: Kim Seong Chan , Choi Min Joo 
Published: June 2021

Abstract
This study aims to verify if the beating sound of a singing bowl synchronizes and activates brain waves. The singing bowl sound used in this experiment strongly beats at the frequency of 6.68 Hz, while it decays exponentially and lasts for about 50 sec. Brain waves were measured for 5 min at the F3 and F4 region of the 17 subjects who heard the beating singing bowl sounds. Experimental results showed that the increases (up to ~ 251 %) in the spectral magnitudes of the brain waves were dominant at the beat frequency, compared to those of any other clinical brain wave frequency bands. The observed synchronized activation of the brain wave at the beating sound frequency supports that the singing bowl sound may effectively facilitate meditation and relaxation, considering that the beat frequency belongs to theta waves which increases in the relaxed meditation state.
Effects of introducing weaned heifers to freestall housing on growth performance and behavior
Authors: Akbarian-Tefaghi Majid , Ahmadi Fatemeh , Ghaffari Morteza Hosseini 
Published: June 2021

Abstract
This study evaluated the effects of two housing types (freestalls vs. bedded-pack) on growth performance and behavior of weaned heifers, with no previous experience with freestalls. Heifers (12 heifers/ treatment) were randomly assigned to each treatment at d 80 ± 3 of age. Heifers had free access to diets and water throughout the experiment. The ADG, structural growth, and final body weight were not affected by the housing type. Also, there was no difference in overall DMI between treatments, but the freestall-housed heifers had greater DMI than those housed in bedded-pack during the last 5 d of the study. There were no differences in any behavioral patterns of drinking, standing, and lying time between heifers housed in freestalls than those housed in bedded-pack. The lengths of rumination bouts were less for freestall-housed heifers than those housed in bedded-pack on day 110. Heifers spent less time lying in the freestalls on day 85 compared to day 110 when they get accustomed to using freestall housing. In summary, our results indicate that the growth performance of weaned heifers were not affected by housing type; however, housing heifers in fresstalls can prepare them for using the freestalls facility for a short period.
Integrated mRNA and microRNA transcriptomic analysis reveals the common and individual responses of zebrafish embryos exposed to four types of graphene quantum dots (GQDs)
Authors: Deng Shun , Zhang Enming , Zhao Yunyang , Wang Yan , Yang Zezhong , Liu Baiming , Liu Li , Zheng Bingxin , Mu Xiaoyuan , Yuan Kezhu , Deng Xuangen , Shen Hai , Rong Haibo , Pei Desheng , Fu Ailing , Li Xia 
Published: June 2021

Abstract
Background: Graphene quantum dots (GQDs) have great potential for bioimaging, biosensor, drug carrier, theranostics, and are recently reported as therapeutic agents to treat amylosis and inflammation. Most types of GQDs have proven low toxicity in previous studies, but data about the transcriptomic responses of in vivo systems exposed to various GQDs remains largely unknown. Results: We examined the mRNA and microRNA (miRNA) expression changes of zebrafish embryos exposed to four types of GQDs at a safe concentration (100 µg/mL), respectively as raw graphene quantum dots (R-GQDs), graphene oxide quantum dots (GOQDs), carboxyl GQDs (C-GQDs), and aminated GQDs (A-GQDs). The four GQDs elicited the number of differentially expressed genes (DEGs) in a decreasing order of A-GQDs, GOQDs, C-GQDs and R-GQDs to act on protein folding, potassium (K+) and calcium (Ca2+) channels, and spliceosome to varying degrees. Among the four GQDs, A-GQDs caused more genotoxic effects associated with lipid and hormone metabolism, MAPK signaling pathway, complement system, and ferropotosis. miRNA-seq data revealed that GOQDs aroused more differentially expressed miRNAs (DEMs), far exceed the total number of DEMs induced by the other three GQDs. dre-miR-735-5p and its potentially interactive gene-myogenin (myog) were identified as the only negatively-correlated miRNA-target gene pair shared by the four GQDs treatments. Conclusion: Taken together, this study provided substantial data underlying the common and specific transcriptomic responses of in vivo systems exposed to various types of GQDs, and also indicated the potential medicinal values of GQDs for ion antagonists and spliceosome-targeted therapies.
Der Wegfall der Personenfreizügigkeit aufgrund des Brexits — Bestandesaufnahme der Beziehung Schweiz-UK
Authors: Steller Sofie 
Published: June 2021

Am 1. Januar 2021 fiel zwischen der Schweiz und dem Vereinigten Königreich durch den Brexit das Freizügigkeitsabkommen (FZA) weg. Mit dem 2019 abgeschlossenen Abkommen über die erworbenen Rechte der Bürgerinnen und Bürger sollen die nach Art. 23 FZA erworbenen Ansprüche geregelt und ausgestaltet werden. Grossteils bewahrt das neue Abkommen im Bereich der Freizügigkeit die Regelungen aus dem FZA, in gewissen Aspekten gestaltet es sich aber auch restriktiver, wobei sich die Frage nach dem Verhältnis zu Art. 23 stellt. Für Personen, die keine erworbenen Ansprüche haben, kommt ein vollständig neues Regime zur Anwendung. So gibt es zwar ein befristetes Abkommen für die Dienstleistungserbringung. Im Übrigen wurde jedoch kein umfassendes Migrationsabkommen abgeschlossen und es kommen die nationalen Regelungen zur Anwendung. Insgesamt sind die Möglichkeiten zur Migration zwischen den beiden Ländern sehr viel begrenzter geworden.
--
Le 1er janvier 2021, la libre circulation des personnes entre la Suisse et le Royaume-Uni en vertu de l'ALCP cesse de s'appliquer en raison du Brexit. L'accord sur les droits acquis des citoyens conclu en 2019 a pour but de réglementer et de structurer les droits acquis en vertu de l'art. 23 ALCP. Pour l'essentiel, le nouvel accord conserve les dispositions de l'ALCP dans le domaine de la libre circulation des personnes, mais il est également plus restrictif sur certains points, ce qui soulève la question de la relation avec l'article 23. Pour les personnes qui n'ont pas de droits acquis, un tout nouveau régime s'applique. En effet, il existe un accord temporaire relatif aux prestations de services. Dans tous les autres domaines, cependant, aucun accord global de migration n'a été conclu et les réglementations nationales s'appliquent. Globalement, les possibilités de migration entre les deux pays sont devenues beaucoup plus limitées.
Synthesis, Molecular Docking and In Vivo Biological Evaluation of
Iminostilbene Linked 1,2,3-Triazole Pharmacophores as Promising Anti-
Anxiety and Anti-Inflammatory Agents
Authors: Ankali Kariyappa N. , Rangaswamy Javarappa , Shalavadi Mallappa , Naik Nagaraja 
Published: June 2021

Background:
Iminostilbene and 1,2,3-triazole ring containing compounds are considered
as beneficial substrates in drug design.

Objectives:
This study was aimed at the synthesis of novel series of iminostilbene linked 1,2,3-
triazole pharmacophores (7c-n) by Cu(I) catalyzed 1,3 dipolar cycloaddition reaction between 5-
(Prop-2-yn-1-yl)-5H-dibenzo[b,f]azepine (7b) and various substituted azidobenzene derivatives (3cn).

Methods:
The chemical structures of compounds were confirmed by 1H NMR, 13C NMR, LC-MS
and molecular docking studies were carried out through HEX docking software.

Results:
The in vivo anti anxiety capacity of the compounds was evaluated by using “elevated plus
maze” (EPM), anxiety model. The results exhibited that compounds (7d, 7e, 7j and 7k) have a higher
anti anxiety effect close to diazepam. The anti-inflammatory activities of the synthesized compounds
were evaluated by “Carrageenan-induced rat paw edema” model, compounds (7b, 7c, 7d, 7f, and 7j)
demonstrated statistically significant inflammatory activity. Molecular docking analysis revealed that
compounds (7d, 7e and 7j) bound to GABA(A) proteins show more efficiency when compared to the
other analogues in the series.

Conclusion:
These results suggest that compounds (7b, 7c, 7d, 7e, 7f, and 7j) can be considered as
novel candidates for anti-anxiety and anti-inflammatory agents. Moreover, docking method was used
to elucidate anti-anxiety effect of compounds. This study furnished insight into the molecular interactions
of synthesized compounds with their physiological targets, and the potential to develop bioactive
heterocyclic compounds.
Potential Biological Targets Prediction, ADME Profiling, and Molecular
Docking Studies of Novel Steroidal Products from Cunninghamella
blakesleana
Authors: Yousuf Maria , Rafi Sidra , Ishrat Urooj , Shafiga Alekberzadeh , Dashdamirova Gulnara , Leyla Vazirova , Iqbal Heydarov 
Published: June 2021

Background:
New potential biological targets prediction through inverse molecular docking technique is an another smart strategy to forecast the possibility of compounds being biologically active against various target receptors.

Objectives:
In this case of designed study, we screened our recently obtained novel acetylinic steroidal biotransformed products [(1) 8-β-methyl-14-α-hydroxy∆4tibolone (2) 9-α-Hydroxy∆4 tibolone (3) 8-β-methyl-11-β-hydroxy∆4tibolone (4) 6-β-hydroxy∆4tibolone, (5) 6-β-9-α-dihydroxy∆4tibolone (6) 7-β-hydroxy∆4tibolone) ] from fungi Cunninghemella Blakesleana to predict their possible biological targets and profiling of ADME properties.

Method:
The prediction of pharmacokinetics properties membrane permeability as well as bioavailability radar properties were carried out by using Swiss target prediction, and Swiss ADME tools, respectively these metabolites were also subjected to predict the possible mechanism of action along with associated biological network pathways by using Reactome data-base.

Results:
All the six screened compounds possess excellent drug ability criteria, and exhibited exceptionally excellent non inhibitory potential against all five isozymes of CYP450 enzyme complex, including (CYP1A2, CYP2C19, CYP2C9, CYP2D6, and CYP3A4) respectively. All the screened compounds are lying within the acceptable pink zone of bioavailability radar and showing excellent descriptive properties. Compounds [1-4 & 6] are showing high BBB (Blood Brain Barrier) permeation, while compound 5 is exhibiting high HIA (Human Intestinal Absorption) property of (Egan Egg).

Conclusion:
In conclusion, the results of this study smartly reveals that in-silico based studies are considered to provide robustness towards a rational drug designing and development approach, therefore in this way it helps to avoid the possibility of failure of drug candidates in the later experimental stages of drug development phases.
Preconcentration of Aluminum by Dual-cloud Point Extraction and its Determination by Inductively Coupled Plasma-optical Emission Spectrometry
Authors: Mortada Wael I. , Alharthi Sarah 
Published: June 2021

Background:
The combination of cloud point extraction (CPE) with inductively coupled
plasma-optical emission spectrometry (ICP OES) is limited due to the effect of organic diluent and
surfactant on the signal.

Methods:
A dual-CPE process (d-CPE) was presented for the enrichment of aluminum (Al3+), before
determination by ICP OES, to exclude the effect of surfactant and organic solvent on the ICP
OES signal. The analyte was firstly extracted into Triton X-114 rich phase as a gallic acid complex.
In the second step, Al3+ was back extracted into an aqueous phase of HNO3 that was introduced into
ICP OES. The effects of pH, concentrations of gallic acid and Triton X-114, incubation temperature
and time, centrifugation conditions and the concomitant ions were evaluated.

Results:
The method displayed good analytical characteristics at the optimum conditions. An enrichment
factor of 49.5 was achieved. The linear calibration graph was obtained from 1.0 to 1000
μg L-1 and the detection limit was 0.31 μg L-1. The relative standard deviation was 2.3% (50 μg L-1
Al3+, n = 10). Quantitative recoveries ranging from 96.0 to 100% were obtained for spiked water
and geological samples. This procedure was used efficiently for preconcentration and quantification
of Al3+ in various samples by ICP OES.

Conclusion:
The presented procedure is simple, rapid, accurate, and safe. It can be used for the
determination of Al3+ by ICP OES in samples with complicated matrices.
IMPLEMENTASI MODEL PEMBELAJARAN ARCS (ATTENTION, RELEVANCE, CONFIDENCE, AND SATISFACTION) PADA MATA PELAJARAN PEKERJAAN DASAR TEKNIK OTOMOTIF (PDTO) UNTUK MENINGKATKAN KEAKTIFAN DAN HASIL BELAJAR SISWA KELAS X TKR A TEKNIK KENDARAAN RINGAN DI SMK NASIONAL BERBAH TAHUN AJARAN 2019/2020
Authors: Solikhin Muhammad 
Published: June 2021

Penelitian ini bertujuan untuk meningkatkan keaktifan dan hasil belajar siswa kelas X TKR A di SMK Nasional Berbah pada mata pelajaran Pekerjaan Dasar Teknik Otomotif melalui implementasi model pembelajaran ARCS. Jenis penelitian ini adalah penelitian tindakan kelas, dengan menggunakan model Kemmis dan Mc. Taggart. Subjek penelitian adalah siswa kelas X TKR A di SMK Nasional Berbah tahun ajaran 2019/2020. Pengambilan data dilakukan melalui lembar observasi untuk mengetahui keaktifan siswa dengan jenis numerical rating scale dengan aspek indikator berupa keberanian peserta didik bertanya, keberanian peserta didik untuk menjawab pertanyaan/mengungkapkan pendapat, interaksipeserta didik dengan guru dan kelompok, perhatian peserta didik selama prosespembelajaran, serta tes evaluasi untuk mengetahui tingkat hasil belajar siswa. Model pembelajaran ARCS dikatakan berhasil meningkatkan keaktifan dan hasil belajar apabila persentase keaktifan mencapai 65 % dan sebanyak 75 % siswa telah tuntas KKM yaitu hasil belajar minimal 75. Hasil penelitian menunjukkan bahwa: 1) implementasi model pembelajaran ARCS pada proses pembelajaran meningkatkan keaktifan siswa kelas X TKR A di SMK Nasional Berbah. Hal ini ditunjukkan dengan keaktifan belajar siswa pada siklus I 55,60 % meningkat pada siklus II sebesar 73,71 %. 2) Implementasi model pembelajaranARCS mampu meningkatkan hasil belajar siswa. Hal ini ditunjukkan dengan nilai rata-rata pada siklus I sebesar 57,5 meingkat pada siklus II dengan rata-rata kelasnya sebesar 75. dengan persentase ketuntasan akhir sebesar 82 % dan persentase keaktifan mencapai 73,71 % di siklus II. Dengan demikian telah mencapai indikator keberhasilan yang ditentukan.
Use of Social Media for Cancer Prevention Through Neighborhood Social Cohesion: Protocol for a Feasibility Study
Authors: Oakley-Girvan Ingrid , Watterson Jessica L , Jones Cheryl , Houghton Lauren C , Gibbons Marley P , Gokal Kajal , Magsamen-Conrad Kate 
Published: June 2021

Background
Social cohesion is associated with healthier behaviors and better health outcomes, and therefore may offer a mechanism for promoting better health. Low socioeconomic status (SES) communities face higher rates of chronic disease due to both community- and individual-level factors.

Objective
The aim of this study is to leverage social cohesion to promote healthier behaviors and prevent chronic disease in a low SES community. This protocol outlines the methodology for a pilot study to assess the feasibility of an intervention (Free Time For Wellness [FT4W]) using a social networking platform (Nextdoor) with mothers living in an urban, low-income community to improve social cohesion and promote healthy behaviors.

Methods
The study will involve three phases: (I) co-designing the intervention with mothers in the neighborhoods of interest, (II) implementing the intervention with community leaders through the social networking platform, and (III) evaluating the intervention’s feasibility. Phase I of the study will include qualitative data collection and analysis from in-depth, semistructured interviews and a co-design group session with mothers. Phases II and III of the study include a pre- and postintervention survey of participating mothers. Neighborhood-level data on social cohesion will also be collected to enable comparison of outcomes between neighborhoods with higher and lower baseline social cohesion.

Results
As of March 2021, recruitment and data collection for this study are complete. This protocol outlines our original study plan, although the final enrollment numbers and intervention implementation deviated from our initial planned methodology that is outlined in this protocol. These implementation learnings will be shared in subsequent publications of our study results.

Conclusions
Ultimately, this study aims to: (1) determine the barriers and facilitators to finding free time for wellness among a population of low-income mothers to inform the co-design process, and (2) implement and study the feasibility of an intervention that leverages social cohesion to promote physical activity in a community of low-income mothers. The results of this study will provide preliminary feasibility evidence to inform a larger effectiveness trial, and will further our understanding of how social cohesion might influence well-being.

International Registered Report Identifier (IRRID)
RR1-10.2196/28147