bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alantolactone exerts anti-proliferative and apoptotic effects on BGC823 and SGC7901 cells via activation of p38MAPK and inhibition of NF-κB signaling pathway
Authors: Ningsheng Xie , Junfeng Xie , Jianhua Tang , Youshun Liu , Yingfeng Wei , Qiuping Gu , Qingtian Luo , Fangqin Zhu Fangqin 
Published: May 2021

Purpose: To investigate the anti-proliferative and apoptotic influences of alantolactone on gastric carcinoma (GC) cell lines, and the mechanism(s) involved.
Methods: Human gastric cancer cell line (BGC823) and gastric adenocarcinoma lymph node metastasis cell line (SGC7901) were maintained in Ham’s F12 medium supplemented with 10 % heatinactivated fetal bovine serum (FBS). In each group of cancer cell line, 5 groups of cells were used: control and four alantolactone groups which were treated with increasing concentrations of alantolactone (5 - 30 μM) for varying periods. Proliferation was determined using MTT assay, while realtime quantitative polymerase chain reaction (qRT-PCR) was used to assay the expressions of apoptosis- and metastasis-related genes. The expressions of p38MAPK and nuclear transcription factor-κB (NF-κB) in BGC823 and SGC7901 cells were measured with Western blotting.
Results: Phosphorylated protein (p-p38 protein) expression was significantly higher in both groups of GC cells, relative to control (p < 0.05). The expressions of NF-κB in plasma protein were markedly higher in both groups of GC cells than in control group, but the corresponding expressions in nuclear protein were significantly lower in both groups of GC cells, relative to control (p < 0.05).
Conclusion: Alantolactone exerts anti-proliferative and apoptotic effects on BGC823 and SGC7901 cells via mechanisms involving activation of the p38MAPK, and inhibition of the NF-κB signaling pathways. Thus, alantolactone may be a new and effective anti-gastric cancer drug.
Effect of Yugan Sanjie decoction on expressions of regulatory T cells, serum P21 protein and vascular endothelial growth factor in mice with hepatocellular carcinoma
Authors: Tan Song , Hou Aihua , Liu Wei , Wang Jinguo , Huang Xiaoming , Mu Yuejun 
Published: May 2021

Purpose: To investigate the effect of Yugan Sanjie decoction on the expressions of regulatory T cells (Tregs), serum P21 protein and vascular endothelial growth factor (VEGF) in mice with hepatocellular carcinoma.
Methods: A total of forty specific-pathogen-free (SPF) Kunming mice were randomly assigned to four groups of 10 mice each. Except for normal control group, the other three groups were transfected with hepatoma-22 (H22) cells to establish a mouse model of liver cancer. Mice in the cyclophosphamide group was given cyclophosphamide at a dose of 20 mg/kg daily intragastrically, while those in decoction group were treated with Yugan Sanjie decoction (0.4 ml/kg/day) intraperitoneally. After 30 days of treatment, serum levels of CD4+ Th17, CD4+CD25+ Treg, Th17/Treg, TNF-α, and VEGF were determined.
Results: There was lower serum level of CD4+ Th17 in the decoction group than in negative control and cyclophosphamide groups (p < 0.05). However, higher serum levels of CD4+CD25+ Treg and Th17/Treg were seen in the decoction group, relative to the negative control and cyclophosphamide groups (p < 0.05). Serum TNF-α was also markedly elevated in decoction group, when compared with negative control and cyclophosphamide groups (p < 0.05). Serum VEGF was markedly lower in decoction group than in negative control and cyclophosphamide groups, and was appreciably lower in cyclophosphamide group than in negative control group (p < 0.05).
Conclusion: Yugan Sanjie decoction effectively alleviates clinical symptoms of LC, and improves immune function of mice by regulating serum levels of T lymphocytes. These findings provide scientific support for a new treatment strategy.
Hh pathway expression in the blood, synovial cells and chondrocytes of different rheumatoid arthritis models
Authors: Wu Yingyi , Yang Guangxia , Fei Jing , Huang Yang 
Published: May 2021

Purpose: To investigate the effect of the hedgehog (Hh) pathway inhibitor, cyclopamine, and activator purmorphamine on articular cartilage cell proliferation.
Methods: Rats were subjected to AA and CIA models. Secondary paw swelling was measured at 12, 15, 18, 21, 24, 27, and 30 days. The rats were sacrificed on day 30. Tissues from the cartilage and knee joints were collected. Cell proliferation was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) assay while cell apoptosis was determined by annexin V-fluorescein isothiocyanate/propidium iodide assay. Protein expression levels of Shh, Ptch1 and Gli1 were determined by Western blotting.
Results: Compared with the control group, arthritis index and secondary foot swelling of the adjuvant arthritis (AA) and collagen-induced arthritis (CIA) groups deteriorated significantly (p < 0.05). MTT data revealed that cyclopamine promoted articular cartilage cell proliferation of the AA and CIA groups. The cell proliferation rates of AA and CIA groups were significantly higher than that of control group (p < 0.05). Flow cytometry showed that the cell apoptosis rates of AA and CIA groups were significantly lower than that of control group (p < 0.05). Compared with control, cyclopamine decreased the protein expression levels of sonic Hh, patched homologue 1 and glioma-associated oncogene homologue, but the effect of purmorphamine was the reverse.
Conclusion: Hh pathway inhibitor (cyclopamine) and activator (purmorphamine) affect the expression of Hh pathway. Disruption of the Hh pathway may be of potential therapeutic significance in protecting articular cartilage from rheumatoid arthritis.
Relación entre las complicaciones y la calidad de vida del paciente en hemodiálisis
Authors: Cuevas Budhart Miguel  Angel , SAUCEDO GARCIA RENATA PATRICIA , ROMERO QUECHOL GUILLERMINA , GARCIA LARUMBE JOSE ALEJANDRO , HERNANDEZ PAZ Y PUENTE ANWAR 
Published: May 2021

Introducción: Los pacientes con Enfermedad Renal Crónica (ERC) son tratados con terapias de diálisis. Dentro de este tipo de tratamiento se encuentran la Diálisis Peritoneal (DP) y Hemodiálisis (HD). Los pacientes sometidos a HD tienen una evolución imprevisible por las complicaciones del tratamiento y/o complicaciones propias de la ERC. Estas aumentan el número de hospitalizaciones y deterioran la calidad de vida (CV). Objetivos: Evaluar la calidad de vida de pacientes en hemodiálisis y determinar la asociación entre las complicaciones y la CV. Material y Método: Estudio transversal analítico en 157 pacientes en HD (75 hombres, 82 mujeres), mayores de 18 años y con más de 3 meses en tratamiento. La CV se evaluó con el instrumento KDQOL-36, el cual, mide 5 dimensiones en escala del 0 al 100. Se realizó un análisis bivariado, ANOVA y regresión múltiple para evaluar la relación de cada una de las dimensiones con edad, sexo, ocupación, estado civil, escolaridad, tipo de acceso venoso, tiempo con la ERC, con la HD y complicaciones de la ERC y la HD. Resultados: La edad promedio fue de 50.9 años. El 77% de los participantes presentaron complicaciones, 69.4% por HD, 5% por evolución de la ERC y 25.6% ambas complicaciones. En el análisis multivariado se encontró que la presencia de ambas complicaciones deteriora más la calidad de vida que las ocasionadas únicamente por el tratamiento de HD. Conclusión: Las complicaciones del tratamiento de hemodiálisis aunadas a las de la ERC deterioran la calidad de vida del paciente.
First Aid Awareness Campaign for Two Undergraduate Nursing Cohorts
Authors: Afifi Mona H. , Dela Rama E. , Al Qahtani Yara A. , Al Dosary Afnan , Hamdi Amnah Y. 
Published: May 2021

Context: First aid is an emergency measure of saving a life, preventing further deterioration, and promoting recovery of the victim before professional medical help is initiated. Awareness campaigns are significant community efforts to raise awareness of community groups regarding critical concerns.
Aim: The aim of this study is to evaluate the effect of the first aid awareness campaign on student knowledge among two undergraduate nursing cohorts.
Methods: A quasi-experimental research (pre/post-test design) is selected to achieve the aim of this study. The study is conducted at King Saud bin Abdel-Aziz University Health Science College. A sample of 82 undergraduate student nurses is allocated from third and fourth years. A structured interview questionnaire is designed to assess the undergraduate student nurses’ cohorts’ level of knowledge regarding first aid.
Results: The study reveals a statistically significant improvement of the two undergraduate nursing cohorts’ level of knowledge in post-test compared to their pre-test scores. A non-statistically significant difference is revealed between two undergraduate nursing student cohorts (3rd and 4th year) level of knowledge after exposure to awareness session.
Conclusion: The study provides evidences of the efficacy of awareness campaigns to raise awareness of such a critical issue as first aid among nursing college students, recommending a separate first aid course for undergraduate nursing students once they start their major nursing courses. The study also recommends further studies for evaluating the effect of awareness campaigns as an active student learning method.
O desenvolvimento da política científica e tecnológica na Primeira República (1889-1930): uma análise a partir dos institutos de pesquisa paulistas e federais
Authors: Sanches Júnior Jefferson de Lara 
Published: May 2021

A Proclamação da República em 1889 trouxe a descentralização política, transferindo o poder decisório para os estados. Durante esse período, o estado de São Paulo passou por um considerável desenvolvimento econômico que também se refletiu na constituição de sua política de ciência e tecnologia, destacando-se a criação de institutos de pesquisa em saúde pública e agricultura, como o Instituto Bacteriológico e o Instituto Biológico. Vemos também que a ação preponderante do governo central realizada ao longo do Império se arrefeceu durante a Primeira República, centrando suas ações no Distrito Federal e na criação de institutos de saúde pública, como o Instituto de Manguinhos. Frente a esse cenário, propomos nesse estudo a análise do panorama científico e tecnológico de São Paulo e do governo federal durante a Primeira República através de seus institutos de pesquisa, destacando as continuidades e rupturas existentes entre ambos.
Evaluation of the effect of plant material on the quality of cooked sausages
Authors: Sarsembekova A. T. , Korzeniowska M. , Uzakov Ya. M. , Zheleuova Zh. S. 
Published: May 2021

Various amounts of buckwheat hulls (1%, 1,5%, and 3%) were added to cooked turkey sausages. The effect of buckwheat hulls on the physicochemical characteristics of the cooked turkey sausages, including, pH, instrumental color, texture profile analysis (TPA), antioxidant content and sensory evaluation, were determined. Increased levels of added buckwheat hulls led to higher antioxidant activity. However, the protein and fat contents of the cooked turkey sausage samples were constant. The instrumental color in control sample were L*=65,1, a*=5,6, and b*=9,8. There were slight differences in the TPA among the treated samples. According to the results of the sensory and objective assessment of consumer properties, it can be argued that sample F1 with the introduction of buckwheat hulls 3,0% had a negative effect on sensory properties of cooked turkey sausages. The best marks were given to the sample F1 with the introduction of buckwheat hulls 1,0% on sensory evaluation.
The key of knowledge
Authors: Barnett Claudia R. 
Published: May 2021

Keys are used to gain access, knowledge, and power but what happens when these everyday items are transformed into supernatural objects? Do they, in turn, become a source of knowledge and power? Charles Perrault played with this concept by portraying a key as a magical lie detector in his infamous ‘Bluebeard’ fairy tale (1695). In this story, the husband is portrayed as a serial killer who uses the lure of forbidden knowledge to manipulate his wife and instigate a series of events to justify her murder. This structuring of crime and punishment within the framework of marriage makes this fairy tale unique. The scholarship attached to Bluebeard’s key includes an examination of this object as a metaphor for female sexual curiosity and infidelity (Bettelheim 1991: 301), and a means of accessing feminine consciousness (Estes 2017: 40). In his 1796 English translation of the French text, R.S. Gent writes that the ‘key was a Fairy’ (28). Gent’s words stirred my imagination; What if the key had been a woman, magically entrapped as a key? Would she tell a different story? This creative interrogation explores the gendered violence and power structures in Perrault’s ‘Bluebeard’ narrative. ‘The key of knowledge’ uses a socio-historical, Foucauldian framework and creative writing research methodology to examine Perrault’s ‘Bluebeard’ as a discourse of disciplinary punishment.
Writing on common ground: the lyric essay as a decolonising form
Authors: Howe Christine 
Published: May 2021

Is it possible for Australian settler writers to decolonise their writing, and if so, what form might this writing take? This paper explores the challenges facing settler writers who wish to respectfully acknowledge the sovereignty of Aboriginal and Torres Strait Islander peoples, and to participate in the movement towards a ’fair and truthful relationship’ (‘Uluru statement from the heart’ 2017). The value of the lyric essay as a poetic form that resists straightforward answers – but rather allows for links to be drawn between the past and the present, complicity and healing, and the land and our experience of it – is explored.
Narrative inquiry, creative nonfiction and two braided stories of the rehabilitation and release of orang-utans in Sebuyau, Sarawak
Authors: Yin Christina 
Published: May 2021

The rehabilitation and release of captive orang-utans remains a contentious issue in the conservation of the endangered species. In the 1970s, three confiscated and captive-raised orang-utans were released at Sebuyau, Sarawak: using narrative inquiry as the research method, the researcher–writer tells the stories of two people instrumental in this experiment. Their stories tell of personal experience working with the rescued animals and the consequences of well-meaning but ill-fated human actions. In this creative nonfiction work, the voices of the wildlife officer, forest guard and researcher–writer take the reader through a gamut of emotions: wonder, compassion, frustration and sorrow. This writing is part of the researcher–writer’s postgraduate work using creative nonfiction to tell the stories of men and women working to conserve the orang-utan over a span of fifty years in Sarawak, Malaysian Borneo.
Disrupting leaps of experience: digital storyworlds, transformative poiesis/praxis and narrative agency
Authors: Le Rossignol Karen 
Published: May 2021

Entering the digital storyworld of Deakinopolis (a narrative-based world of interrelated settings, characters and situations) is about imaginatively entering an alternative fictional storyworld that largely presents as factual, an experience that mirrors tertiary learners’ realities. Malouf talks of experience of story as ’… being taken out of ourselves into the skin of another; having adventures there that are both our own and not our own … Release … into a dimension where reality is not limited’ (2008: 19). The digital storyworld of Deakinopolis contains alternative or imagined realities, where learners project their own experience in making this world coherent through their engagement with potentially unsettling perspectives. To encourage agency in active learner exploration, the storyworld is suspended out of time and sequence so that participants can imagine themselves through lapsed borders into that seemingly peripheral world. The learners activate their immersive engagement in this digital storyworld through praxical experience of unsettling perspectives, with potential for disrupting singular perspectives into transformative immersion of imagination as poiesis.
Out of sight: the censoring of family diversity in picture books
Authors: Mokrzycki Sarah 
Published: May 2021

Family diversity has long been censored, silenced, and ignored in Australian picture books. Despite its long running representation in books for older readers, the concept of exploring family diversity at picture book level remains nothing short of radical. Of the little available, much comes in the form of issue-driven books and from specialist presses overseas, presenting a distinct gap in Australian children’s literature. The contentious history of diversity in children’s books creates added issues in the struggle for representation, and diverse stories (and diverse authors) face ongoing challenges. Furthermore, public outrage at the ‘shunning’ of nuclear families, as well as society’s distorted understanding of what constitutes diversity, present further complications in the advocating for family-diverse stories. This essay will examine what it means to be a family, the issues surrounding family diversity in picture books, and why such books deserve to be championed.
A common space: translation, transcreation, and drama
Authors: Glance Vivienne , Jaccomard Hélène 
Published: May 2021

Internationally renowned French playwright and novelist Yasmina Reza’s ten plays have been translated into more than 35 languages, with the exception of Dans la luge d’Arthur Schopenhauer, or On Arthur Schopenhauer’s Sledge (2005). This short play is made up of eight monologues for stage but is resolutely non-dramatic. The translation of such a hybrid text from French into English is a first-time collaboration between a translator, Hélène Jaccomard, and a transcreator, Vivienne Glance. Prior to this, Glance, the transcreator, has been working with limited-English speaking authors to co-transcreate their works into English, doing so with no knowledge of their mother tongue. In contrast, for On Arthur Schopenhauer’ Sledge, Glance worked on a rough English translation, with some knowledge of the original French but no access to the author. Professional experience of acting and directing plays allowed the transcreator to ensure each character’s voice sounded natural, true, and distinctive in English. Jaccomard, the translator, translated the French text into English, a second language, when literary translators typically work into their first language. Jaccomard’s command of English was often challenged by transferring a source language that is both abstract and precise, tackles philosophical ideas, and creates the characters’ moods and humour. This paper analyses how co-transcreation practice between Jaccomard and Glance operates in the space common to translation for the stage, close textual analysis, and drama performance.
Perakitan Wastafel Otomatis dan Sosialisasi Protokol Kesehatan Dalam Menghadapi Pandemi Covid-19
Authors: Mahbub Asep Ramdhani , Hantoro Kusdarnowo , Warta Joni 
Published: May 2021

Coronavirus Disease 2019 (Covid-19) adalah penyakit yang disebabkan oleh virus corona jenis baru yang menyerang sistem pernapasan dan bisa menyebabkan gangguan ringan pada sistem pernapasan, infeksi paru-paru yang berat, hingga kematian. Sehingga, World Health Organization (WHO) menetapkan Covid-19 sebagai pandemi global. Data Badan Nasional Penanggulangan Bencana (BNPB) menunjukan kasus positif di Indonesia juga semakin bertambah sehingga pemerintah menerapkan PSBB serta tatanan hidup normal baru, salah satunya adalah dengan menyosialisasikan 3M yaitu memakai masker, mencuci tangan, dan menjaga jarak. Sarana/perangkat cuci tangan manual yang digunakan secara bersama-sama dapat menjadi media penyebaran virus sehingga harus diminimalisir, salah satunya yaitu dengan menggunakan wastafel otomatis serta dengan terus melaksanakan protokol kesehatan. Hasil ujicoba sensor air dan sensor sabun cair dapat beroperasi dengan baik pada rentang jarak 1-6 cm terhadap objek di depan sensor
The Malvinas (Falkland) Plateau Derived from Africa? Constraints for its Tectonic Evolution
Authors: Ramos Víctor , Chemale Farid , Lovecchio Juan Pablo , Naipauer Maximiliano 
Published: May 2021

The latest studies on the tectonic evolution of the Malvinas (Falkland) Islands and their adjacent continental plateau further east are analyzed to assess a long controversy regarding the origin of these islands. Although there has been a controversy for several decades on this subject, new technologies and exploratory drilling have brought new data, however the debate of the geological evolution of this area remains open. The two dominant hypotheses are analyzed by assessing the eventual collision between the islands and the South American continent, the presence of a large transcontinental fault such as Gastre, the potential 180º rotation of the Malvinas Islands, and the occurrence of a mega-decollement with opposite vergence. These hypotheses are contrasted with the processes that have occurred in Patagonia, especially those based on the new isotopic data on the Maurice Ewing Bank at the eastern end of the Malvinas Plateau, and the current knowledge of the adjacent Malvinas Basin. The new data highlights the inconsistencies of certain models that proposed these islands migrated from the eastern African coasts near Natal, to their current position and rotated 180º on a vertical axis. The new observations are consolidating the hypothesis that postulates that the islands have been part of the South American continent since before the Paleozoic.
To Be on the High Wire Without a Safety Net: On Physical Actions as Prayer Between Beckett and Grotowski
Authors: Salonna Ilaria 
Published: May 2021

ABSTRACT
Starting from Simone Weil's association between the involvement of the faculty of attention and prayer, this article explores the relation between spirituality and performance through the analysis of performer's work on Samuel Beckett, focusing in particular on the sense of the act of praying in the text Happy Days. First, it considers some contributions of performers engaged in playing Beckett that underlines the essential role of attention in the execution of a complex dramatic composition. Second, the essay focuses on the consequences of such work on the level of the bodily presence and how the body could physically be active while actually being “absent” or in conditions of restraint. This brings evidence to a special quality of the performer's work and form of embodiment that, according to Eugenio Barba, is familiar to the Asian techniques of theatre and, for Jerzy Grotowski, could be defined with the metaphoric expression “carnal prayer.”
“No Palestinian House Is Without Tears”
Authors: Zimmerman Laurie 
Published: May 2021

Abstract
This article argues that as American Jewish support for Israel wanes American Jews need a new Jewish ethical framework in which to understand the Israeli-Palestinian conflict. It extends the discourse beyond a Jewish narrative and examines the values of empathy and responsibility toward Palestinians, as well as the importance of recognizing historical injustices perpetrated by Israel. This article draws on the work of scholars and discusses their ideas in conjunction with the author's experiences as a congregational rabbi. It evaluates the dual-narrative approach and then focuses on the work of Bashir Bashir and Amos Goldberg to explore how narratives such as me-shoah le-tekumah, from the destruction of the Holocaust to the rebirth of Israel, can lead American Jews to view the Palestinian experience as entirely separate from their own.