bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between air flow limitation and body composition in young adults
Authors: Muñoz-Cofré Rodrigo , Lizana Pablo A. , Cabello Máximo Escobar , García-Herrera Claudio , del Sol Mariano 
Published: January 2021

Abstract
Background
Body composition (BC) influences respiratory system mechanics, provoking air flow limitation (AFL). The objective of this study was to determine the relationship of AFL in small- and medium-caliber airways with BC in young adults.

Methods
Eighty-three individuals were recruited (40 men and 43 women). To determine AFL, the following measurements were taken: forced expiratory volume in the first second (FEV1), forced expiratory flow between 25 and 75% (FEF25–75%), airway resistance (Raw), and specific airway resistance (sRaw). The measured BC variables were body mass index (BMI), body fat percentage (%BF), and fat-free mass (FFM). Binary logistical regression analysis was used to estimate the association between the AFL variables and %BF, BMI, and %FFM, adjusting for weight and gender.

Results
Among men, a relationship was observed between Raw and %BF (r = 0.728; p < 0.0001) and sRaw and BMI (r = 0.617; p < 0.0001). Among women, significant relationships were reported between Raw and BMI (r = 0.615; p < 0.0001) and sRaw and BMI (r = 0.556; p < 0.0001). Among participants with a BMI over 30 kg/m2, higher risks of increased Raw (OR = 26.8; p = 0.009) and sRaw (OR = 9.3; p = 0.002) were observed. Furthermore, higher %BF was associated with greater risks for increased Raw (OR = 14.04; p = 0.030) and sRaw (OR = 4.14; p = 0.028). In contrast, increased %FFM (OR = 0.14; p = 0.025) was a protective factor for lung function.

Conclusion
Increased %BF is associated with increased AFL in small-caliber airways. Furthermore, increased %FFM is associated with decreased risk for Raw and sRaw in women. Therefore, evidence indicates that increased %FFM is a protective factor for adequate lung function.
Cholestyramine treatment in two dogs with presumptive bile acid diarrhoea: a case report
Authors: Toresson L. , Steiner J. M. , Suchodolski J. S. 
Published: January 2021

Abstract
Background
In people, bile acid diarrhoea is a prevalent complication of Crohn’s disease and diarrhoea-associated irritable bowel syndrome. Affected patients typically respond to bile acid sequestrants, such as cholestyramine, but human gastroenterologists often fail to recognize bile acid diarrhoea. Consequently, bile acid diarrhoea is regarded as an underrecognized and undertreated condition in human medicine. Due to lack of diagnostic tools, clinical response to bile acid sequestrants is often used to confirm a diagnosis of bile acid diarrhoea in people.
Several recent studies have shown that bile acid dysmetabolism also occurs in dogs with chronic enteropathies. It has further been shown that dogs with chronic enteropathies have significantly decreased expression of a bile acid transport protein in the ileum compared to healthy dogs, which correlates with faecal bile acid dysmetabolism. Consequently, in spite of the lack of reports in the literature, bile acid diarrhoea is likely to exist in dogs as well.

Case descriptions
Two dogs, an 8-year old Rottweiler and a 4.5-year old Siberian Husky were evaluated for chronic watery diarrhoea. Neither dog responded to dietary trials, probiotics, cyclosporine, faecal microbial transplantations or metronidazole. One of the dogs responded to high daily doses of corticosteroids, which were however associated with unacceptable side effects. The other dog was refractory to all standard treatment protocols, including cyclosporine and corticosteroids. Since none of the dogs responded satisfactorily to standard treatment or modulation of the intestinal microbiome, a suspicion of possible bile acid diarrhoea was raised. Treatment with cholestyramine, a bile acid sequestrant was initiated and resulted in marked improvement of faecal consistency, frequency of defecation and activity level in both dogs.

Conclusion
This report presents two dogs with presumed bile acid diarrhoea that were successfully treated with cholestyramine. Therefore, bile acid diarrhoea should be considered as a possible diagnosis in dogs with treatment-refractory chronic diarrhoea.
Impacts of attending an inclusive STEM high school: meta-analytic estimates from five studies
Authors: Means Barbara , Wang Haiwen , Wei Xin , Young Viki , Iwatani Emi 
Published: January 2021

Abstract
Background
Inclusive STEM high schools seek to broaden STEM participation by accepting students on the basis of interest rather than test scores and providing a program sufficient to prepare students for a STEM major in college. Almost nonexistent before the present century, these high schools have proliferated over the last two decades as a strategy for addressing gaps in STEM education and career participation. This study uses a meta-analytic approach to investigate the relationship between attending an inclusive STEM high school and a set of high school outcomes known to predict college entry and declaration of a STEM college major.

Results
Combining effect estimates from five separate datasets of students from inclusive STEM high schools and matched comparison schools, the analysis reported here used data from administrative records and survey data for 9719 students in 94 high schools to obtain estimates of the average impact of attending an inclusive STEM high school on STEM-related high school outcomes. Positive effects for inclusive STEM high schools were found for completion of key STEM courses and for likelihood that students would engage in self-selected STEM activities. Students who attended an inclusive STEM high school also identified more strongly with mathematics and science and were more likely as high school seniors to be very interested in one or more STEM careers. Importantly, these positive impacts were found for low-income, under-represented minority, and female students as well as for students overall. Attending an inclusive STEM high school appeared to have a small positive impact on science test scores for students overall and for economically disadvantaged students, but there were no discernible impacts on mathematics test scores.

Conclusions
These findings suggest that the inclusive STEM high school model can be implemented broadly with positive impacts for students, including low-income, female, and under-represented minority students. Positive impacts on the odds of taking advanced mathematics and science courses in high school and on interest in entering a STEM profession are of particular importance, given the strong association between these variables and entry into a STEM major in college.
Improved image reconstruction of 89Zr-immunoPET studies using a Bayesian penalized likelihood reconstruction algorithm
Authors: Kirchner Julian , O’Donoghue Joseph A. , Becker Anton S. , Ulaner Gary A. 
Published: January 2021

Abstract
Purpose
The aim of this study was to evaluate the use of a Bayesian penalized likelihood reconstruction algorithm (Q.Clear) for 89Zr-immunoPET image reconstruction and its potential to improve image quality and reduce the administered activity of 89Zr-immunoPET tracers.

Methods
Eight 89Zr-immunoPET whole-body PET/CT scans from three 89Zr-immunoPET clinical trials were selected for analysis. On average, patients were imaged 6.3 days (range 5.0–8.0 days) after administration of 69 MBq (range 65–76 MBq) of [89Zr]Zr-DFO-daratumumab, [89Zr]Zr-DFO-pertuzumab, or [89Zr]Zr-DFO-trastuzumab. List-mode PET data was retrospectively reconstructed using Q.Clear with incremental β-values from 150 to 7200, as well as standard ordered-subset expectation maximization (OSEM) reconstruction (2-iterations, 16-subsets, a 6.4-mm Gaussian transaxial filter, “heavy” z-axis filtering and all manufacturers’ corrections active). Reduced activities were simulated by discarding 50% and 75% of original counts in each list mode stream. All reconstructed PET images were scored for image quality and lesion detectability using a 5-point scale. SUVmax for normal liver and sites of disease and liver signal-to-noise ratio were measured.

Results
Q.Clear reconstructions with β = 3600 provided the highest scores for image quality. Images reconstructed with β-values of 3600 or 5200 using only 50% or 25% of the original counts provided comparable or better image quality scores than standard OSEM reconstruction images using 100% of counts.

Conclusion
The Bayesian penalized likelihood reconstruction algorithm Q.Clear improved the quality of 89Zr-immunoPET images. This could be used in future studies to improve image quality and/or decrease the administered activity of 89Zr-immunoPET tracers.
Effects of timing of umbilical cord clamping on preventing early infancy anemia in low-risk Japanese term infants with planned breastfeeding: a randomized controlled trial
Authors: Shinohara Eriko , Kataoka Yaeko , Yaju Yukari 
Published: January 2021

Abstract
Background
Japanese infants have relatively higher risk of anemia and neonatal jaundice. This study aimed to assess the effects of delayed cord clamping (DCC) on the incidence of anemia during early infancy in low-risk Japanese term infants with planned exclusive breastfeeding for 4 months. This study also aimed to explore the effects of DCC on neonatal jaundice.

Methods
We conducted an open-label, parallel-arm, multicenter randomized controlled trial of DCC (clamping the cord after more than a minute or pulsation stops) vs. early cord clamping (ECC; clamping the cord within 15 s) at one birth center and two clinics in Japan. Low-risk pregnant women planning to have a vaginal birth and to exclusively breastfeed and term singleton infants delivered in cephalic presentation were included in this study. The primary outcome was spectrophotometric estimation of hemoglobin at 4 months. Secondary outcomes were anemia incidence at 4 months, four outcomes related to neonatal jaundice, hematocrit levels, and related outcomes.

Results
Overall, 150 pregnant women were recruited. Participants (N = 138) were randomly allocated to two groups (DCC n = 68, ECC n = 70). There were no significant differences between the two groups in spectrophotometric estimation of hemoglobin at 4 months: mean difference = 0.1 g/dL, 95% confidence interval − 0.14, 0.35, DCC 12.4 g/dL, ECC 12.3 g/dL. Only the hematocrit levels on days 3 to 5 were significantly higher in the DCC group than in the ECC group: DCC 57.0%, ECC 52.6%, mean difference = 4.4, 95% confidence interval 2.61, 6.20. There were no significant differences in other secondary outcomes, including outcomes related to neonatal jaundice.

Conclusion
Among low-risk Japanese term infants with planned exclusive breastfeeding, DCC showed no significant effects on spectrophotometric hemoglobin levels at 4 months compared with ECC. We observed significantly higher hematocrit levels on days 3 to 5 in infants who underwent DCC, while these levels were within the normal range. Jaundice outcomes remained similar to those of infants who underwent ECC. Although a larger sample size is required to assess the effects of cord clamping on neonatal jaundice, DCC may prevent anemia in newborn infants.

Trial registration
UMIN-CTR; UMIN000022573, 06/01/2016 - retrospectively registered, https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000023056
Engaging with diverse audiences to raise awareness about childhood eczema: reflections from two community events
Authors: Gilbertson Anna , Ridd Matthew J. , Sutton Eileen , Liddiard Lyn , Clayton Julie , Roberts Amanda , Chan Jonathan , Bhanot Alisha , Wellesley Rosie , Dawson Shoba 
Published: January 2021

Abstract
Background
Eczema is a common childhood condition, causing dry and itchy skin which can be difficult to manage. We have been undertaking eczema and food allergy research to address previously prioritised research questions. We obtained funding to trial novel approaches to reach diverse audiences to raise awareness of childhood eczema, research, and public involvement in research.

Methods
This paper reflects on two public engagement events held in collaboration with stakeholders in two settings of ethnic diversity in East Bristol, UK. We invited parents and children to attend the events by public display of posters. We created novel activities related to the research and involved artists to engage parents/carers and children about eczema and the research we are doing into its management.

Results
Attendance at the first event was lower than expected. Lessons learned were incorporated into the second event, to use a more structured approach and attract greater numbers of parents/carers from more diverse backgrounds. Creative approaches such as using artists at both events made the subject more accessible for diverse audiences, including children.

Conclusion
We successfully delivered two public engagement events. The success of the events has generated individual interest in PPI and enquiries about future events from neighbouring community groups. Reflections from the events have also been fed back to inform the research.
High prevalence of Clonorchis sinensis infection in Guangxi, Southern China
Authors: Jiang Zhi-Hua , Wan Xiao-Ling , Lv Guo-Li , Zhang Wei-Wei , Lin Yuan , Tang Wen-Qian , Wei Hai-Yan , Ou Fang-Qi , Shi Yun-Liang , Yang Yi-Chao , Liu Jian , Chan Carlos H. F. 
Published: January 2021

Abstract
Background
Soil-transmitted helminths (STHs), such as hookworm, roundworm and whipworm, and food-borne trematodiases, including Clonorchis sinensis, remain a public health problem worldwide, especially in tropical and subtropical regions.

Objective
We aimed to determine the current prevalence of these parasites in Guangxi, China, which is located in a subtropical region.

Methods
A cross-sectional study and a 4-year longitudinal surveillance study were carried out. Stool samples were collected and examined microscopically for parasite eggs using the modified Kato-Katz thick smear method.

Results
The study subjects selected using stratified random cluster sampling for the cross-sectional study and longitudinal surveillance study numbered 15,683 and 24,429, respectively. In the cross-sectional study, hookworm, roundworm, whipworm, pinworm, C. sinensis, and tapeworm were found. The total prevalence of soil-transmitted helminths (STHs) was 6.4% (95% CI, 6.0-6.8). The prevalences of C. sinensis, hookworm, roundworm, whipworm, and pinworm were 10.6%, 4.2%, 0.3%, 0.3%, and 1.8%, respectively. The prevalence of C. sinensis in males (14.0%, 95% CI, 13.3-14.8) was significantly higher than in females (7.2%, 95% CI, 6.7-7.8) (P = 0.0001). The prevalence also was significantly higher in the medical worker group (20.8%, 95% CI, 12.9-28.7) than in all other occupational groups (10.5%, 95% CI, 10.0-11.0) (P = 0.0001). The prevalence of hookworm in females (5.3%, 95% CI, 4.8-5.8) was significantly higher than in males (3.0%, 95% CI, 2.6-3.3) (P = 0.0001). In the longitudinal surveillance study, the prevalence of C. sinensis and STHs in 2016, 2017, 2018, and 2019 were 12.0%, 6.0%, 11.0%, and 10.0% and 2.6%, 2.8%, 1.5%, and 1.5%, respectively.

Conclusions
Adult male and occupation of and medical workers are risk factors for infection with C. sinensis and hookworm. The prevalence rate of C. sinensis remains high while those of the other STHs are decreasing, suggesting that enhanced health education should be focused on C. sinensis in Guangxi.
Stress hyperglycemia as a prognostic factor in acute ischemic stroke patients: a prospective observational cohort study
Authors: El-Gendy Hanaa A. , Mohamed Mahmoud A. , Abd-Elhamid Amr E. , Nosseir Mohammed A. 
Published: January 2021

Abstract
Background
Hyperglycemia is a risk factor for infarct expansion and poor outcome for both diabetic and non-diabetic patients. We aimed to study the prognostic value of stress hyperglycemia on the outcome of acute ischemic stroke patients as regards National Institutes of Health Stroke Scale (NIHSS) as a primary outcome.

Results
Patients with high random blood sugar (RBS) on admission showed significantly higher values of both median NIHSS score and median duration of hospital stay. There were significant associations between stress hyperglycemia and the risk of 30-day mortality (p < 0.001), the need for mechanical ventilation (p < 0.001) and vasopressors (p < 0.001), and the occurrence of hemorrhagic transformation (p = 0.001). The 24-h RBS levels at a cut off > 145 mg/dl showed a significantly good discrimination power for 30-day mortality (area under the curve = 0.809).

Conclusions
Stress hyperglycemia had a prognostic value and was associated with less-favorable outcomes of acute stroke patients. Therefore, early glycemic control is recommended for those patients.
Brazilian recommendations for the use of nonsteroidal anti-inflammatory drugs in patients with axial spondyloarthritis
Authors: da Cruz Lage Ricardo , Marques Claudia Diniz Lopes , Oliveira Thauana Luiza , Resende Gustavo Gomes , Kohem Charles Lubianca , Saad Carla Gonçalves , Ximenes Antônio Carlos , Gonçalves Célio Roberto , Bianchi Washington Alves , de Souza Meirelles Eduardo , Keiserman Mauro Waldemar , Chiereghin Adriano , Campanholo Cristiano Barbosa , Lyrio André Marun , Schainberg Cláudia Goldenstein , Pieruccetti Lenise Brandao , Yazbek Michel Alexandre , Palominos Penelope Esther , Goncalves Rafaela Silva Guimarães , Assad Rodrigo Luppino , Bonfiglioli Rubens , Lima Sônia Maria Alvarenga Anti Loduca , Carneiro Sueli , Azevedo Valderílio Feijó , Albuquerque Cleandro Pires , Bernardo Wanderley Marques , Sampaio-Barros Percival Degrava , de Medeiros Pinheiro Marcelo 
Published: January 2021

AbstractSpondyloarthritis (SpA) is a group of chronic inflammatory systemic diseases characterized by axial and/or peripheral joints inflammation, as well as extra-articular manifestations. Over some decades, nonsteroidal anti-inflammatory drugs (NSAIDs) have been the basis for the pharmacological treatment of patients with axial spondyloarthritis (axSpA). However, the emergence of the immunobiologic agents brought up the discussion about the role of NSAIDs in the management of these patients. The objective of this guideline is to provide recommendations for the use of NSAIDs for the treatment of axSpA. A panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis of randomized clinical trials for 15 predefined questions. The Grading of Recommendations, Assessment, Development and Evaluation methodology to assess the quality of evidence and formulate recommendations were used, and at least 70% agreement of the voting panel was needed. Fourteen recommendations for the use of NSAIDs in the treatment of patients with axSpA were elaborated. The purpose of these recommendations is to support clinicians’ decision making, without taking out his/her autonomy when prescribing for an individual patient.
Treatment of knee osteoarthritis with a new formulation of a fixed-dose combination of glucosamine sulfate and bovine chondroitin: a multicenter, randomized, single-blind, non-inferiority clinical trial
Authors: Lomonte Andrea Barranjard Vannucci , Gimenez Emerson , da Silva Antônio Carlos , Radominski Sebastião Cezar , Scheinberg Morton Aaron , Ximenes Antônio Carlos , de Freitas Zerbini Cristiano Augusto 
Published: January 2021

Abstract
Objectives
To compare the efficacy and safety of a new formulation of a fixed dose combination of glucosamine sulfate (GS; 1500 mg) and bovine chondroitin sulfate (CS; 1200 mg) versus the reference product (RP) in patients with knee osteoarthritis (OA).

Methods
In this multicenter, randomized, single-blind trial, 627 patients with knee osteoarthritis (OA)—Kellgren-Lawrence grades 2 or 3 and mean score ≥ 40 mm in the WOMAC pain subscale—were randomized to receive GS/CS or the RP for 24 weeks. The primary efficacy endpoint was the absolute change in WOMAC pain subscale score. The secondary endpoints included the following: WOMAC total and subscale scores, overall assessment of the disease by the patient and the investigator, SF-12 score, OMERACT-OARSI response rate to the treatment, and rescue medication use.

Results
Mean reductions of WOMAC pain score were − 35.1 (sd = 23.2) mm in the GS/CS group and − 36.5 (sd = 24.9) mm in the RP group. The difference between the adjusted means of both treatments confirmed the non-inferiority of GS/CS versus the RP. Improvement was observed in pain, stiffness, physical function and total WOMAC score, as well as in overall OA assessment by the patient and the investigator for both groups. No improvement was observed in SF-12. The rate of OMERACT-OARSI responders was 89.4% in GS/CS group and 87.9% in the RP group. Headache and changes in glucose tolerance were the most frequent treatment-related adverse events.

Conclusions
The new formulation of a fixed-dose combination of glucosamine sulfate and bovine chondroitin sulfate was non-inferior to the RP in symptomatic treatment of knee OA, with a high responder rate and good tolerability profile.

Trial registration
ClinicalTrials.gov; Registration number NCT02830919; Date of registration: July 13, 2016; First randomization date: December 05, 2016).
Inoculation with rumen fluid in early life accelerates the rumen microbial development and favours the weaning process in goats
Authors: Palma-Hidalgo Juan Manuel , Jiménez Elisabeth , Popova Milka , Morgavi Diego Pablo , Martín-García Antonio Ignacio , Yáñez-Ruiz David Rafael , Belanche Alejandro 
Published: January 2021

Abstract
Background
Newborn ruminants possess an underdeveloped rumen which is colonized by microorganisms acquired from adult animals and the surrounding environment. This microbial transfer can be limited in dairy systems in which newborns are separated from their dams at birth. This study explores whether the direct inoculation of fresh or autoclaved rumen fluid from adult goats to newborn kids has a beneficial effect on rumen microbial development and function.

Results
Repetitive inoculation of young kids with fresh rumen fluid from adult goats adapted to forage (RFF) or concentrate diets (RFC) accelerated microbial colonization of the rumen during the pre-weaning period leading to high protozoal numbers, a greater diversity of bacterial (+ 234 OTUs), methanogens (+ 6 OTUs) and protozoal communities (+ 25 OTUs) than observed in control kids (CTL) without inoculation. This inoculation also increased the size of the core bacterial and methanogens community and the abundance of key rumen bacteria (Ruminococcaceae, Fibrobacteres, Veillonellaceae, Rikenellaceae, Tenericutes), methanogens (Methanobrevibacter ruminantium, Methanomicrobium mobile and Group 9), anaerobic fungi (Piromyces and Orpinomyces) and protozoal taxa (Enoploplastron, Diplodinium, Polyplastron, Ophryoscolex, Isotricha and Dasytricha) before weaning whereas CTL kids remained protozoa-free through the study. Most of these taxa were positively correlated with indicators of the rumen microbiological and physiological development (higher forage and concentrate intakes and animal growth during the post-weaning period) favoring the weaning process in RFF and RFC kids in comparison to CTL kids. Some of these microbiological differences tended to decrease during the post-weaning period, although RFF and RFC kids retained a more complex and matured rumen microbial ecosystem than CTL kids. Inoculation with autoclaved rumen fluid promoted lower development of the bacterial and protozoal communities during the pre-weaning period than using fresh inocula, but it favored a more rapid microbial development during the post-weaning than observed for CTL kids.

Conclusions
This study demonstrated that inoculation of young ruminants with fresh rumen fluid from adult animals accelerated the rumen microbial colonization which was associated with an earlier rumen functional development. This strategy facilitated a smoother transition from milk to solid feed favoring the animal performance during post-weaning and minimizing stress.