bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colostrum IgA1 antibodies recognize antigens from Helicobacter pylori and prevent cytoskeletal changes in human epithelial cells
Authors: Baltierra‐Uribe Shantal Lizbeth , Montañez‐Barragán Alejandra , Romero‐Ramírez Héctor , Klimov‐Kravtchenko Ksenia , Martínez‐Pedro Karla Ivette , Sánchez‐Salguero Erick , Camorlinga‐Ponce Margarita , Torres Javier , Santos‐Argumedo Leopoldo 
Published: August 2021

AbstractHelicobacter pylori is a Gram‐negative bacterium found on the luminal surface of the gastric mucosa in at least 50% of the world's human population. The protective effect of breastfeeding against H. pylori infection has been extensively reported; however, the mechanisms behind this protection remain poorly understood. Human IgA from colostrum has reactivity against H. pylori antigens. Despite that IgA1 and IgA2 display structural and functional differences, their reactivity against H. pylori had not been previously determined. We attested titers and reactivity of human colostrum‐IgA subclasses by ELISA, immunoblot, and flow cytometry. Colostrum samples from healthy mothers had higher titers of IgA; and IgA1 mostly recognized H. pylori antigens. Moreover, we found a correlation between IgA1 reactivity and their neutralizing effect determined by inhibition of cytoskeletal changes in AGS cells infected with H. pylori. In conclusion, colostrum‐IgA reduces H. pylori infection of epithelial gastric cells, suggesting an important role in preventing the bacteria establishment during the first months of life. As a whole, these results suggest that IgA1 from human colostrum provides protection that may help in the development of the mucosal immune system of newborn children.
Development An Amperometric Microbial‐enzyme Hybrid Cholesterol Biosensor Based On Ionic Liquid MWCNT Carbon Paste Electrode
Authors: Canbay Erhan , Yaşa İhsan , Akyilmaz Erol 
Published: August 2021

AbstractIn this study we report the development of an amperometric cholesterol biosensor based on cholesterol oxidase from Pseudomonas sp. and catalase immobilized in carbon paste electrode (CPE) modified with multiwall carbon nanotubes (MWCNT) and ionic liquid (IL). The working electrode (CPE/MWCNT‐IL/Microorganism (MO)‐Catalase) was characterized by impedance spectroscopy and cyclic voltammetry at different stages of its construction. This proposed cholesterol biosensor performed linear relationship in the range of 5–600 μM with a low detection limit of 1.52 μM. The biosensor showed good sensitivity and high selectivity and it was successfully applied for the measurement of cholesterol levels in lyophilized serum samples.
Indoor light energy harvesting for battery‐powered sensors using small photovoltaic modules
Authors: Shore Andrew , Roller John , Bergeson Jennifer , Hamadani Behrang H. 
Published: August 2021

AbstractAs interest in Internet‐of‐Things (IoT) devices like wireless sensors increases, research efforts have focused on finding ways for these sensors to self‐harvest energy from the environment in which they are installed. Photovoltaic (PV) cells or mini‐modules are an intuitive choice for harvesting indoor ambient light, even under low light conditions, and using it for battery charging and powering of these devices. Characterizations of battery charging, for small rechargeable batteries from low charge to full charge, have been investigated using PV mini‐modules of equal area. We present battery charging results using three different PV technologies, monocrystalline silicon (c‐Si), gallium‐indium‐phosphide (GaInP), and gallium‐arsenide (GaAs) under a warm color temperature (3000 K) LED lighting at an illuminance of 1000 lx. Battery charging times are shortest for the more efficient GAInP and GaAs mini‐modules whose spectral response is a better match to the LED test source, which contains mostly visible photons, and longest for the less efficient Si cells. As a demonstration, a wireless temperature sensor mote was attached to the charging circuit and operated to determine its power consumption in relation to the available charging power. The mote's maximum power draw was less than the charging power from the least efficient c‐Si mini‐module. Our findings affirm the feasibility of utilizing PV under typical indoor lighting conditions to power IoT devices.
Random forest versus logit models: Which offers better early warning of fiscal stress?
Authors: Jarmulska Barbara 
Published: August 2021

AbstractThis study seeks to answer whether it is possible to design an effective and useful machine learning‐based early warning system signaling a risk of fiscal stress in the near future. To do so, multiple models based on econometric logit and the random forest models are designed and compared. Using a dataset of 20 annual frequency variables pertaining to 43 advanced and emerging countries during 1992–2018, the results confirm the possibility of obtaining an effective model, which correctly predicts 70–80% of fiscal stress events and tranquil periods. The random forest‐based early warning model outperforms logit models both in terms of aggregate forecasting properties and when applied to an example of the euro area sovereign debt crisis. While the very effective random forest model is commonly understood to provide lower interpretability than logit models do, this study employs tools that can be used to provide useful information for understanding what is behind the black‐box. These tools can provide information on the most important explanatory variables and on the shape of the relationship between these variables and the outcome classification. Thus, the study contributes to the discussion on the usefulness of machine learning methods in economics.
Forecasting expected shortfall and value at risk with a joint elicitable mixed data sampling model
Authors: Xu Qifa , Chen Lu , Jiang Cuixia , Liu Yezheng 
Published: August 2021

AbstractLow‐frequency risk measures can filter out noise and better reflect the trend. In order to improve the forecasting accuracy of low‐frequency risk through making full use of the valuable information contained in high‐frequency independent variables, we propose a novel joint elicitable mixed data sampling (JE‐MIDAS) model by introducing MIDAS method into JE regression model. We utilize the JE‐MIDAS model to forecast value at risk and expected shortfall simultaneously and compare its performance with that of other popular models through both the Monte Carlo simulations and real‐world applications. The numerical results show that our model is superior to other models because it can model mixed‐frequency data directly, which avoids the information loss caused by frequency conversion. The empirical results on three stock indices also show that market volatility can increase financial risk. Interest rate has positive effects on risks for U.S. S&P500 and U.K. FTSE, whereas negative for SHCI of China.
Female infertility and herbal medicine: An overview of the new findings
Authors: Akbaribazm Mohsen , Goodarzi Nader , Rahimi Mohsen 
Published: August 2021

AbstractInfertility is defined as the failure to achieve a successful pregnancy after 12 months’ sexual activity that affects 15%–17% of couples in the world and about 50% of them are related to female infertility factors. In this study, using the PRISMA checklist and MeSH keywords, 128 articles were extracted from various databases (PubMed, Cochrane library, WHO, Iranmedex, Science Direct, SID, and Google Scholar search engine) without language and time restrictions, and 128 articles were selected after eliminating duplicate studies. In this review, we present some solid evidence for role of herbal medicine in the treatment of female infertility. The results of this study showed that different parts of some plants are rich in polyphenolic compounds (isoflavones and flavonoids) and other compounds which are beneficial to in reproductive health in women. The compounds in these plants, along with regulating the female endocrine pathways, and improving symptoms of menopause, treat female reproductive disorders such as polycystic ovary syndrome (PCOS), premature ovarian failure (POF), endometriosis, hyperprolactinemia, and hypothalamic dysfunction; moreover, because of their anticancer, antioxidant, and antidepressant properties, they can be used in traditional medicine or in the pharmaceutical industry as safe compounds in women's health.
Provenance, nature, and U–Pb zircon geochronology of Ngaye rocks (Adamawa‐Yadé Shield, Central Cameroon): New insights into the evolution of Archean crust within the Pan‐African belt
Authors: Assomo Ngono Gaelle Sandra , Ganwa Alembert Alexandre , Ntomba Sylvestre Martial , Ndjigui Paul‐Désiré 
Published: August 2021

Petrographical, geochemical, and geochronological data obtained from Ngaye high‐grade metasedimentary rocks have contributed to determine the provenance, nature, and evolutionary history of the Adamawa‐Yadé Domain from the Archean to Pan‐African events. The rocks are migmatites formed after TTG and granitic crusts were reworked by partial melting at T = 683–994°C. Geochemical features, for example, low Rb/Sr ratio (0.03–0.53), high Cr/V, and Cr/Th ratios (9.91–100.75; 28.41–686.15), respectively, indicate that these samples were derived predominantly from a mafic crust source. The primordial mantle‐normalized spidergrams are characterized by negative Nb‐Ta anomalies, suggesting melting of crustal rocks. REE fractionation shown (La/Yb)N = 8.48–197.89) indicate melting of crustal source rocks (meta‐TTGs). Low Hf and Zr contents (0.95–5.65 ppm and 23–262.85 ppm, respectively), low Sr/Y ratios (9.17–200.65), and a positive correlation between Th/Sc and Zr/Sc, point to crustal reworking. U–Pb ages on detrital zircon in tonalitic and granodioritic gneisses indicate contribution of Mesoarchean and Paleoproterozoic sources and suggest a maximum deposition age during the Early Paleoproterozoic for their magmatic protoliths. Magmatic zircon grains of granodiorite, with a round shape, Th/U ratio values ranging from 0.02 to 1.23, and an oscillatory zonation yield post emplacement metamorphic ages at 2,077 Ma. The lower intercept ages obtained in this study, match the tectonic reworking of the crust during the Pan‐African event associated with partial melting due probably to regional‐scale shear zone activities and magmatic accretion of juvenile magmas.
G protein‐coupled estrogen receptor‐1 enhances excitatory synaptic responses in the entorhinal cortex
Authors: Batallán Burrowes Ariel A. , Sundarakrishnan Adithi , Bouhour Camille , Chapman Clifton Andrew 
Published: August 2021

AbstractActivation of estrogen receptors is thought to modulate cognitive function in the hippocampus, prefrontal cortex, and striatum by affecting both excitatory and inhibitory synaptic transmission. The entorhinal cortex is a major source of cortical sensory and associational input to the hippocampus, but it is unclear whether either estrogens or progestogens may modulate cognitive function through effects on synaptic transmission in the entorhinal cortex. This study assessed the effects of the brief application of either 17‐β estradiol (E2) or progesterone on excitatory glutamatergic synaptic transmission in the female rat entorhinal cortex in vitro. Rats were ovariectomized on postnatal day (PD) 63 and also received subdermal E2 implants to maintain constant low levels of circulating E2 on par with estrus. Electrophysiological recordings from brain slices were obtained between PD70 and PD86, and field excitatory postsynaptic potentials (fEPSPs) reflecting the activation of the superficial layers of the entorhinal cortex were evoked by the stimulation of layer I afferents. The application of E2 (10 nM) for 20 min resulted in a small increase in the amplitude of fEPSPs that reversed during the 30‐min washout period. The application of the ERα agonist propylpyrazoletriol (PPT) (100 nM) or the β agonist DPN (1 μM) did not significantly affect synaptic responses. However, the application of the G protein‐coupled estrogen receptor‐1 (GPER1) agonist G1 (100 nM) induced a reversible increase in fEPSP amplitude similar to that induced by E2. Furthermore, the potentiation of responses induced by G1 was blocked by the GPER1 antagonist G15 (1 μM). Application of progesterone (100 nM) or its metabolite allopregnanolone (1 μM) did not significantly affect synaptic responses. The potentiation of synaptic transmission in the entorhinal cortex induced by the activation of GPER1 receptors may contribute to the modulation of cognitive function in female rats.
Teflon Magnetic Stirring Capsules (TMSC) as a Practical and Reusable Delivery System for Sensitive Reagents and Catalysts
Authors: Taillemaud Sylvain , Rosset Stéphane , Mazet Clément 
Published: August 2021

AbstractThe development of a user‐friendly reusable laboratory equipment for the delivery of sensitive reagents and catalysts is described. The tightness of these Teflon Magnetic Stirring Capsules (TMSC) is ensured by the magnetic force and release of the reagent inside the solution is triggered by adjusting the stirring rate so that the centrifuge force exceeds the magnetic force. They can be loaded with several chemicals at the same time and do operate across a broad range of temperatures. The inertness of Teflon facilitates reaction purification.
Exergetic analysis of different water depths evacuated tubessolar still
Authors: More Sunil , Daniel Joseph 
Published: August 2021

AbstractThe paper presents an energy and exergetic analysis of simple and evacuated tubes solar still. Experimental analysis was carried out on a 1 m2 basin area and a total of 18 evacuated tubes are attached to the lower side of the solar still. The results revealed that the highest exergetic efficiency of 70.8% and 34.6% was achieved in 0.03 m water depth passive and active solar still, respectively. The work is also focused on the evaluation of the exergy destruction in the basin liner, water, and the glass cover of the solar still. The maximum exergy destruction rate was found in the basin liner and the minimum is found in the glass cover for both simple and evacuated tube solar still for all water depths. The maximum exergy destruction of 3068 and 5129 W/m2 was observed in the basin liner of 0.05 m water depth simple and evacuated tube solar still.
A new conditioning regimen with chidamide, cladribine, gemcitabine and busulfan significantly improve the outcome of high‐risk or relapsed/refractory non‐Hodgkin's lymphomas
Authors: Ji Jie , Liu Zhigang , Kuang Pu , Dong Tian , Chen Xinchuan , Li Jian , Zhang Chuanli , Liu Jiazhuo , Zhang Li , Shen Kai , Liu Ting 
Published: August 2021

AbstractPrevious studies highlight the need for a more active conditioning therapy in high‐risk or refractory and relapsed lymphomas. Our preclinical research shows that histone deacetylase inhibitors, such as either vorinostat or chidamide, sensitize lymphoma cells to the cytotoxic combination of cladribine, gemcitabine and busulfan, leading to cell apoptosis. To evaluate the efficacy of this chidamide‐cladribine‐gemcitabine‐busulfan (ChiCGB) combination as a new conditioning therapy, we conducted a Phase II trial, as described here. Patients with high‐risk, relapsed/refractory lymphomas received ChiCGB as conditioning therapy, after transplantation with autologous peripheral stem cells. The sample comprised 105 patients in total: 60 with B‐cell non‐Hodgkin lymphomas (B‐NHL) and 45 with T‐cell or natural killer/T‐cell lymphoma (NK/T). All patients eventually achieved full hematopoietic recovery. Neutrophils and platelets were engrafted at a median of 10 days (8‐14) and 13 days (8‐38), respectively. There was no transplant‐related mortality within 100 days of transplant. Neutropenic fever, mucositis and atopic dermatitis were the observed nonhematologic toxicities. At a median follow‐up of 35.4 months, 80.6% of the patients presented with no tumor progression, and the overall survival (OS) reached as high as 86.1%. Concerning the OS rate, 94.5% of patients with B‐NHL and 75.4% of patients with T‐cell or NK/T lymphomas survived. These findings demonstrate the safety and validity of the proposed combined therapy for high‐risk and refractory/relapsed lymphomas. Our study was registered on the Clinical Trial Registry (clinicaltrials.gov, NCT03151876).
Expression of tertiary lymphoid structure in deferred cytoreductive nephrectomy of metastatic renal cell carcinoma treated with nivolumab plus ipilimumab
Authors: Sazuka Tomokazu , Fujimoto Ayumi , Sato Hiroaki , Arai Takayuki , Imamura Yusuke , Sakamoto Shinichi , Ikeda Jun‐ichiro , Ichikawa Tomohiko 
Published: August 2021

IntroductionTertiary lymphoid structure expression and immune checkpoint inhibitors have been attracting attention, and their relationship with renal cell carcinoma is controversial.Case presentationTwo patients with nivolumab plus ipilimumab treatment response for metastatic renal cell carcinoma underwent cytoreductive nephrectomy and regional lymph node dissection. In both cases, the renal tumor site expressed tertiary lymphoid structures. Despite the absence of treatment after a deferred cytoreductive nephrectomy and the short postoperative observation period, the patients still survived.ConclusionTertiary lymphoid structures were expressed in deferred cytoreductive nephrectomy specimen in cases treated with nivolumab plus ipilimumab.
Explaining stock markets' performance during the COVID‐19 crisis: Could Google searches be a significant behavioral indicator?
Authors: Vasileiou Evangelos 
Published: August 2021

SummaryThe purpose of this study is to examine the impact of the pandemic on the performance of stock markets, focusing on the behavioral influence of the fear due to COVID‐19. Using a data set of 10 developed countries during the period December 31, 2019, to September 30, 2020, we examine the impact of COVID‐19 on the performance of the stock markets. We incorporate the impact of the COVID‐19 pandemic using the following variables: (a) the number of new COVID‐19 cases, which was widely used as the main explanatory variable for market performance in early financial studies, and (b) a Google Search index, which collects the number of Google searches related to COVID‐19 and incorporates the health risk and the fear of COVID‐19 (the higher the number of searches for Covid terms, the higher the index value, and the higher the fear index). We employ our input into an EGARCH(1,1,1) model, and the findings show that the Google Search index enables us to draw statistically significant information regarding the impact of the COVID‐19 fear on the performance of the stock markets. On the other hand, the variable of the number of new COVID‐19 cases does not have any statistically significant influence on the performance of the stock markets. Google searches could be a useful tool for supporters of behavioral finance, scholars, and practitioners.
The selection of photoinitiators for photopolymerization of biodegradable polymers and its application in digital light processing additive manufacturing
Authors: Wang Chia‐Chun , Chen June‐Yo , Wang Jane 
Published: August 2021

AbstractDigital light processing additive manufacturing (DLP‐AM) technology has received a lot of attention in the field of biomedical engineering due to its high precision and customizability. However, some photoinitiators, as one of the key components in DLP‐AM, may present toxicity and limit the application of DLP‐AM toward biomedical applications. In order to gain further insights into the correlation between biocompatibility and photoinitiators in photoresins, a study on the selection of photoinitiators used in DLP‐AM is conducted. The light absorbance range and cytocompatibility of four photoinitiators, vitamin B2 combined with triethanolamine (B2/TEOA), diphenyl(2,4,6‐trimethylbenzoyl)phosphine oxide (TPO), 2‐dimethoxy‐2‐phenylacetophenone (DMPA), and 2‐hydroxy‐4‐(2‐hydroxyethoxy)‐2‐methylpropiophenone (I2959), are characterized. Each photoinitiator is then combined with poly(glycerol sebacate) acrylate (PGSA) and poly(ε‐caprolactone) diacrylate (PCLDA), to evaluate their miscibility and film formation ability through photopolymerization. The mechanical properties, in vitro and in vivo biocompatibility studies on bulk films are investigated. It is found that B2/TEOA and TPO exhibit a wider light absorbance range than I2959 and DMPA. PGSA films with B2/TEOA (PGSA‐B2/TEOA) is capable of sustaining cell proliferation up to 10 days and showing low immune responses after 14 days post implantation, proving its biocompatibility. Although B2/TEOA requires longer photopolymerization time, the mechanical strength of PGSA‐B2/TEOA is comparable to PGSA films with TPO and DMPA, and this combination is 3D‐printable through DLP‐AM at the rate of 100 s per layer. In summary, B2/TEOA is a promising photoinitiator for 3D printing.
Strategies for constructing pluripotent stem cell‐ and progenitor cell‐derived three‐dimensional cardiac micro‐tissues
Authors: Chu Xinyue , Wang Mingyu , Qiu Xiaoyan , Huang Yun , Li Tong , Otieno Edward , Li Na , Luo Li , Xiao Xiong 
Published: August 2021

AbstractThree‐dimensional (3D) cardiac micro‐tissue is a promising model for simulating the structural and functional features of heart in vitro. This scientific achievement provides a platform for exploration about the mechanisms on the development, damage, and regeneration of tissue, hence, paving a way toward development of novel therapies for heart diseases. However, 3D micro‐tissue technology is still in its infant stages faced with many challenges such as incompleteness of the tissue microarchitecture, loss of the resident immune cells, poor reproducibility, and deficiencies in continuously feeding the nutrients and removing wastes during micro‐tissue culturing. There is an urgent need to optimize the construction of 3D cardiac micro‐tissue and improve functions of the involved cells. Therefore, scaffolds and cell resources for building 3D cardiac micro‐tissues, strategies for inducing the maturation and functionalization of pluripotent stem cell‐ or cardiac progenitor cell‐derived cardiomyocytes, and the major challenges were reviewed in this writing to enable future fabrication of 3D cardiac micro‐tissues or organoids for drug screening, disease modeling, regeneration treatment, and so on.
Identification and validation of 12 immune‐related genes as a prognostic signature for colon adenocarcinoma
Authors: Tang Dongxin , Huang Wei , Yang Zhu , Wu Xin , Sang Xianan , Wang Kuilong , Cao Gang 
Published: August 2021

AbstractColon adenocarcinoma (COAD) is a common malignant tumor of the digestive tract that threatens human health seriously. Thus, it is urgent to explore biomarkers that can be used to evaluate a patient's survival prognosis overall as a supplementary treatment. RNA‐seq expression profiles were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus, and Lasso and multivariate Cox regression analyses were used for developing the prognostic model. Finally, a nomogram comprising the prognostic model was established to evaluate survival overall. A risk model comprised of a total of 12 immune‐related gene pairs was constructed. Further analysis revealed the model's independent prognostic ability in relation to other clinical characteristics. This model's nomogram could help clinicians choose personalized treatment for COAD patients. This model has significant potential to complement COAD's clinical identifying characteristics, and also provide new insights into the identification of colon cancer patients with a high risk of death.