bluuebunny/crossref_metadata_2025_split huggingface dataset:
The KOALA-study: study protocol for a comprehensive study of cognitive biases in adolescent anorexia nervosa patients compared to healthy and clinical controls
Authors: Sfärlea Anca , Lukas Linda , Schulte-Körne Gerd , Platt Belinda 
Published: October 2021

Abstract
Background
Anorexia nervosa (AN) is characterized by dysfunctional cognitions including cognitive biases at various levels of information processing. However, less is known about the specificity of these biases, i.e., if they occur for eating-disorder-related information alone or also for non-eating-disorder-related emotional information in AN patients (content-specificity) and if they are unique to individuals with AN or are also shown by individuals with other mental disorders (disorder-specificity).

Methods
The present study systematically assesses cognitive biases in 12–18-year-old female adolescents with AN on three levels of information processing (attention, interpretation, and memory) and with regard to two types of information content (eating-disorder-related, i.e., stimuli related to body weight and shape, and non-eating-disorder-related). To address not only content- but also disorder-specificity, adolescents with AN will be compared not only to a healthy control group but also to a clinical control group (adolescents with major depression or particular anxiety disorders). Cognitive biases are assessed within a single experimental paradigm based on the Scrambled Sentences Task. During the task eye movements are recorded in order to assess attention biases while interpretation biases are derived from the behavioural outcome. An incidental free recall test afterwards assesses memory biases. We expect adolescents with AN to show more pronounced negative cognitive biases on all three levels of information processing and for both types of content compared to healthy adolescents. In addition, we expect the specificity of biases to translate into differential results for the two types of content: AN patients are expected to show stronger biases for disorder-related stimuli but similar or less pronounced biases for non-disorder-related stimuli compared to the clinical control group.

Discussion
This is the first study to comprehensively assess cognitive biases in adolescents with AN. It will have essential implications not only for cognitive-behavioural models of AN but also for subsequent studies aiming to modify cognitive biases in this population, thereby addressing important maintaining factors already at an early stage of the disorder.
RETRACTED ARTICLE: Impact of rural tourism on residents’ well-being in traditional ancient villages: a case of North Guangxi
Authors: Zhang Xin 
Published: October 2021

Abstract
The impact of tourism on traditional Chinese villages is a topical issue; there are enough studies on this subject showing different views of the researchers. The recent trend towards cultural mutation and gradual disappearance of ancient traditions in rural areas is evident in developing countries. The study aims to examine the impact of rural tourism development on Chinese villagers’ welfare. The research data were collected in 2010 and 2020 by a survey method. Since the survey relies heavily on respondents’ perceptions, the survey results are somewhat subjective. However, the pretest–posttest study design partially solved this problem. Statistical processing was performed using the Student’s t-test; all data sets were checked for the normality of the distribution. The study concluded that there has been a significant socio-economic improvement in rural areas in the last decade (expansion of population’s purchasing power, enrichment of the cultural sphere), but despite this there is a tendency of migration from the villages to the cities, which is explained by gaps in regional policy.
Plant-based nanoparticles prepared from protein containing tribenuron-methyl: fabrication, characterization, and application
Authors: Heydari Moslem , Yousefi Ali Reza , Nikfarjam Nasser , Rahdar Abbas , Kyzas George Z. , Bilal Muhammad 
Published: October 2021

Abstract
Background
Tribenuron-methyl is a registered herbicide for broad-leaf weed control in wheat, however, low solubility in water and reacting with hard water's ions could substantially decrease its efficacy. The present work aimed to enhance the dispersing and bioactivity of this herbicide by developing nanoparticles using zein as a promising nano-delivery system and to assess the effects of nanoparticles on the efficacy of tribenuron-methyl in the suppression of Convolvulus arvensis as a problematic weed in wheat fields.

Results
Based on SEM analyses nanoparticles sizes were 80–120 nm. DLS results showed an average size of 170 nm for tribenuron-methyl zein-based nanoparticles (TMZNP-5). The entrapment efficiency (EE%) of tribenuron-methyl inside the zein nanoparticles was ca. 81% ± 3. Five-week after application of tribenuron-methyl nanoparticles on C. arvensis, it was able to reduce the dry weight (53%), acetolactate synthase (ALS) enzyme activity (82%), and plant height (77%) of C. arvensis as compared with untreated plants. Additionally, tribenuron-methyl used in nanoparticles at the half rate of the recommended dose had the same efficacy as commercial tribenuron-methyl.

Conclusion
Based on these results, zein nanoparticles can be potentially utilized as nanocarriers for enhancing the solubility of tribenuron-methyl to further enhance its bioavailability and performance on sensitive weeds.

Graphic abstract
Microscopic studies on severing properties of actin-binding protein: its potential use in therapeutic treatment of actin-rich inclusions
Authors: Kim Han-ul , Bharda Anahita Vispi , Moon Jeong Chan , Jeoung Dooil , Chung Jeong Min , Jung Hyun Suk 
Published: October 2021

AbstractActin is an important unit of the cytoskeletal system, involved in many cellular processes including cell motility, signaling, and intracellular trafficking. Various studies have been undertaken to understand the regulatory mechanisms pertaining actin functions, especially the ones controlled by actin-binding proteins. However, not much has been explored about the molecular aspects of these proteins implicated in various diseases. In this study, we aimed to demonstrate the molecular properties of gelsolin, an actin-severing protein on the disassembly of the aggregation of actin-rich intracellular inclusions, Hirano body. We observed a decreasing tendency of actin aggregation by co-sedimentation assay and transmission electron microscopy in the presence of gelsolin. Therefore, we provide suggestive evidence for the use of actin-severing protein in novel therapeutic strategies for neurodegenerative conditions.
Association between intensive care unit admission of a patient and mental disorders in the spouse: a retrospective matched-pair cohort study
Authors: Miyamoto Yuki , Ohbe Hiroyuki , Goto Tadahiro , Yasunaga Hideo 
Published: October 2021

AbstractBackgroundPrevious prospective studies have suggested that spouses of patients who are admitted to the intensive care unit (ICU) have a high prevalence of mental disorders, termed post-intensive care syndrome-family (PICS-F). However, it remains unclear whether the patient’s ICU admission is associated with the occurrence of mental disorders in the spouse outside of the prospective study setting. We therefore investigated the proportion of ICU patients’ spouses who visited medical facilities for mental disorders and the association between ICU admission of a patient and mental disorders in the spouse using real-world data.MethodsThis was a retrospective matched-pair cohort study using commercially available, routinely collected administrative claims data. As the study population, we identified all married couples (both wife and husband) who were registered in the database from 1 April 2012 to 31 August 2018 using family identification codes. We identified spouses of patients who were admitted to the ICU for more than 2 days as the exposure group and defined the date of admission to the ICU as the index date. We randomly matched four individuals in the non-exposure group with one individual in the exposure group. The primary outcome was any PICS-F–related mental disorder in the spouses within 6 months from the index date. As a sensitivity analysis, we also investigated the proportion and association of individuals (excluding spouses) with a history of mental disorders.ResultsAmong 1,082,208 married couples, we identified 8490 spouses of ICU patients, and they were matched with 33,946 individuals. The proportion of any PICS-F–related mental disorder within 6 months from the index date was 12.8% in ICU patients’ spouses and 11.3% in the matched individuals (adjusted odds ratio, 1.29; 95% confidence interval, 1.03–1.42). The sensitivity analysis showed significant associations between ICU admission and spouses’ mental disorders.ConclusionsSpouses of patients who were admitted to the ICU had a slightly higher risk of mental disorders within 6 months than spouses of patients who were not admitted to the ICU.
The mechanism and pattern of injuries of undocumented immigrants crossing the Texas-Mexico border along the Rio Grande Valley
Authors: Palacio Carlos H. , Cruz Bianca , Vanier Cheryl , Cano Jose , Scott Bradford G. 
Published: October 2021

Abstract
Background
Apprehensions of undocumented immigrants in the Rio Grande Valley sector of the U.S.-Mexico border have grown to account for nearly half of all apprehensions at the border. The purpose of this study is to report the prevalence, mechanism, and pattern of traumatic injuries sustained by undocumented immigrants who crossed the U.S.-Mexico border at the Rio Grande Valley sector over a span of 5 years and were treated at a local American College of Surgeons verified Level II trauma center.

Methods
A retrospective chart review was conducted from January 2014 to December 2019. Demographics, comorbidities, injury severity score (ISS), mechanism of injury, anatomical part of the body affected, hospital and ICU length of stay (LOS), and treatment costs were analyzed. Descriptive statistics for demographics, injury location and cause, and temporal trends are reported. The impact of ISS or surgical intervention on hospital LOS was analyzed using an analysis of covariance (ANCOVA).

Results
Of 178 patients, 65.2% were male with an average age of 31 (range 0–67) years old and few comorbidities (88.8%) or social risk factors (86%). Patients most commonly sustained injuries secondary to a border fence-related incident (33.7%), fleeing (22.5%), or motor vehicle accident (16.9%). There were no clear temporal trends in the total number of patients injured, or in causes of injury, between 2014 and 2019. The majority of patients (60.7%) sustained extremity injuries, followed by spine injuries (20.2%). Border fence-related incidents and fleeing increased risk of extremity injuries (Odds ratio (OR) > 3; p < 0.005), whereas motor vehicle accidents increased risk of head and chest injuries (OR > 4; p < 0.004). Extremity injuries increased the odds (OR: 9.4, p < 0.001) that surgery would be required. Surgical intervention was common (64%), and the median LOS of patients who underwent surgery was 3 days more than those who did not (p < 0.001).

Conclusion
In addition to border fence related injuries, undocumented immigrants also sustained injuries while fleeing and in motor vehicle accidents, among others. Extremity injuries, which were more likely with border fence-related incidents, were the most common type. This type of injury often requires surgical intervention and, therefore, a longer hospital stay for severe injuries.
Arthroscopic management of elbow stiffness
Authors: Sanchez-Sotelo Joaquin 
Published: October 2021

AbstractThe elbow is particularly prone to stiffness. Loss of elbow motion is very limiting, and can be the result of trauma, primary osteoarthritis, heterotopic ossification and other conditions. Several exposures have been described for open elbow contracture release. Although a few decades ago elbow arthroscopy was considered only for diagnosis and removal of loose bodies, contemporary arthroscopic techniques allow successful management of the majority of conditions leading to elbow stiffness. Careful patient evaluation, use of advanced imaging studies, and acquisition of appropriate surgical skills are essential for the successful arthroscopic management of the stiff elbow. This expert opinion reviews some fundamentals of elbow stiffness as well as principles for the evaluation and arthroscopic management of the stiff elbow.
The composition of mixed-species flocks of birds in and around Chitwan National Park, Nepal
Authors: Gosai Kamal Raj , Goodale Eben 
Published: October 2021

AbstractBackgroundMixed-species flocks (MSFs) have been well sampled in the South Asia, but there has been as yet surprisingly little work on MSFs of Nepal, despite a diverse and well-studied avifauna. We surveyed MSFs in two forest types in and around the Important Bird Area of Chitwan National Park in Nepal, between 150 and 800 m a.s.l., to provide a first description of the composition of MSFs in this area. We also aimed to understand which species should be considered ‘nuclear species’, important to forming MSFs or leading them forward.ResultsIn total, we collected records on 222 MSFs that included 100 species, and 6097 individuals. The MSFs were similar to worldwide patterns in being dominated by leaf-gleaning, non-terrestrial insectivores. However, the MSFs were more dominated by canopy species than usual, and did not have a clear gregarious, understory leading species. Rather drongos (Family Dicruridae) and minivets (Family Campephagidae, GenusPericrocotus) acted as leaders, and a cluster analysis of composition showed one group of large body size MSFs particularly characterized by the presence of the Greater Racket-tailed Drongo (Dicrurus paradiseus).ConclusionsDrongos are known to provide both costs and benefits to other flock participants: they are aggressive birds that can steal food, and manipulate other species with their vocalizations, but at the same time they are ‘sentinel species’ that produce information about predation risk other species can use. This study demonstrates that drongos can be considered nuclear species for some types of MSFs, despite the potential costs of their presence. MSFs led by sentinel species thus may form in Asia, as well as in the Neotropics.
Allergens of the urushiol family promote mitochondrial dysfunction by inhibiting the electron transport at the level of cytochromes b and chemically modify cytochrome c1
Authors: Pacheco Rodrigo , Quezada Sergio A. , Kalergis Alexis M. , Becker María Inés , Ferreira Jorge , De Ioannes Alfredo E. 
Published: October 2021

AbstractBackgroundUrushiols are pro-electrophilic haptens that cause severe contact dermatitis mediated by CD8+effector T-cells and downregulated by CD4+T-cells. However, the molecular mechanism by which urushiols stimulate innate immunity in the initial stages of this allergic reaction is poorly understood. Here we explore the sub-cellular mechanisms by which urushiols initiate the allergic response.ResultsElectron microscopy observations of mouse ears exposed to litreol (3-n-pentadecyl-10-enyl-catechol]) showed keratinocytes containing swollen mitochondria with round electron-dense inclusion bodies in the matrix. Biochemical analyses of sub-mitochondrial fractions revealed an inhibitory effect of urushiols on electron flow through the mitochondrial respiratory chain, which requires both the aliphatic and catecholic moieties of these allergens. Moreover, urushiols extracted from poison ivy/oak (mixtures of 3-n-pentadecyl-8,11,13 enyl/3-n-heptadecyl-8,11 enyl catechol) exerted a higher inhibitory effect on mitochondrial respiration than did pentadecyl catechol or litreol, indicating that the higher number of unsaturations in the aliphatic chain, stronger the allergenicity of urushiols. Furthermore, the analysis of radioactive proteins isolated from mitochondria incubated with3H-litreol, indicated that this urushiol was bound to cytochrome c1. According to the proximity of cytochromes c1and b, functional evidence indicated the site of electron flow inhibition was within complex III, in between cytochromes bL(cyt b566) and bH(cyt b562).ConclusionOur data provide functional and molecular evidence indicating that the interruption of the mitochondrial electron transport chain constitutes an important mechanism by which urushiols initiates the allergic response. Thus, mitochondria may constitute a source of cellular targets for generating neoantigens involved in the T-cell mediated allergy induced by urushiols.
The effects of pediatric primary prevention programs on screen-time and reading habits of children in Jordan
Authors: Yousuf Mustafa S. , Harvey Heather Lea , Parahoo Sanjai K. , Ziadeh Basil Shawkat , Kilani Muna , Al-Kamil Eman 
Published: October 2021

AbstractThe proliferation of electronic content and limited exposure of children to books in Jordan has made both parents and health-care providers more concerned about healthy child development. This research aimed to determine if pediatric primary prevention programs were helpful in reducing screen-time and improving reading habits of children in Jordan, and if there was a correlation between these two factors. Parents attended classes on various topics, one of which dealt with screen-time and reading. Six months later, they were surveyed on these topics. The test group (took the relevant class) and control group (did not take the class) included 30 families each. The mean screen-time was above the recommended guideline of 2 h/day in both groups. Only 37% of the families in the test group, and 17% in the control group followed the guideline. A significant difference in screen-time between the groups was found only during weekends. When asked about the ideal screen-time, parents from the test group reported screen-times that were significantly closer to the recommendations, showing an increase in knowledge, but not a significant change in behavior. Parents, also, believed that children’s exposure to books should be at the much later age of 3–4 years, with actual exposure being < 1 h/day. Moreover, no correlation was found between screen-time and reading time. These findings suggest that short, evidence-based classes helped raise awareness, but were not sufficient for parents to fully adopt the guidelines. Programs that promote behavior modification should be explored to reinforce knowledge gained from educational classes.
Treatment of multiple huge liver cysts in a hybrid operating room: a case report
Authors: Ishikawa Sho , Kuroda Shintaro , Chosa Keigo , Okada Kenjiro , Tanimine Naoki , Tahara Hiroyuki , Ohira Masahiro , Ide Kentaro , Kobayashi Tsuyoshi , Ohdan Hideki 
Published: October 2021

Abstract
Background
Liver cysts are common, with most cases being asymptomatic. In symptomatic cases, the disease is amenable to treatment. However, huge or multiple liver cysts with vascular narrowing and associated systemic symptoms are extremely rare. Furthermore, the performance of a reliable and effective surgery in such cases remains a major problem. Here, we report a case of multiple giant liver cysts with impaired blood flow surgically treated in a hybrid operating room.

Case presentation
A 73-year-old male presented to a previous doctor with leg edema and dyspnea on exertion; computed tomography revealed that the cause complaint was right lung and heart compression and inferior vena cava (IVC) stenosis due to huge liver cysts in the caudal lobe. The patient was referred to our hospital because of disease recurrence despite percutaneous aspiration of the cyst. Multiple liver cysts were observed in addition to the drained cysts, two of which were located on both sides of the IVC and caused IVC stenosis. We performed open surgery for the liver cysts and used the hybrid operating room for intraoperative IVC angiography and measuring the hepatic vein and portal vein (PV) pressure. We performed unroofing of the hepatic cyst and cauterization of the cyst wall on the hepatic side. Angiography was performed before and after unroofing of the liver cysts, and IVC stenosis release was confirmed. IVC pressure measured at the peripheral side of the stenosis and PV pressures were continuously measured during surgery and were confirmed to have decreased during the opening of the liver cysts. The patient had a good postoperative course and was discharged on the 10th postoperative day. No recurrence was observed 6 months postoperatively.

Conclusions
Cyst unroofing surgery using angiography in a hybrid operating room is a useful treatment for deep hepatic lesions in that vascular stenosis improvement can be intraoperatively confirmed. Moreover, in cases wherein the cyst compresses the vasculature, intraoperative monitoring of IVC and PV pressures can be used to prove that the liver cyst is hemodynamically involved.
Prevalence, Characteristics, Association Factors of and Management Strategies for Low Back Pain Among Italian Amateur Cyclists: an Observational Cross-Sectional Study
Authors: Battista Simone , Sansone Lucia Grazia , Testa Marco 
Published: October 2021

Abstract
Background
Low back pain (LBP) is a burdensome problem affecting amateur cyclists. This cross-sectional study analysed Italian amateur cycling cohort’s demographic and sport-specific characteristics, the prevalence and characteristics of LBP among this population, its possible association factors, the management strategies adopted to deal with LBP and the sample’s beliefs among possible LBP triggers. A web-based cross-sectional survey was created. The questionnaire included 56 questions divided into six sections, querying the sample’s demographic, clinical, and cycling characteristics. Binomial logistic regression with a Wald backward method was performed to ascertain the effects of some covariates (“Sex”, “Age”, “Body Mass Index”, “Sleep hours”, “Work type”, “Cycling year”, “Number of training sessions per week”, “Stretching sessions”, “Being supervised by a coach or following a scheduled training”, “Other sports practised regularly”, “Number of cycling competitions per year”, “Past biomechanic visits”, “Specific pedal training”, “LBP before cycling”) on the likelihood of developing LBP in the last 12 months.

Results
A total of 1274 amateur cyclists answered the survey. The prevalence of LBP appeared to be 55.1%, 26.5% and 10.8% in life, in the last 12 months and the last 4 weeks, respectively. The final model of the logistic regression included the covariates “Sex”, “Work type”, “Cycling year”, “Being supervised by a coach or following a scheduled training”, “Other sports practised regularly”, “Specific pedal training”, “LBP before cycling”, among which “Cycling year” (variable “Between 2 and 5 years” vs. “Less than 2 years”, OR 0.48, 95% CI [0.26–0.89]), “Being supervised by a coach or following a scheduled training” (OR 0.53, 95% CI [0.37–0.74]), “Specific pedal training” (OR 0.69, 95% CI [0.51–0.94]), and “LBP before cycling” (OR 4.2, 95% CI [3.21–5.40]) were found to be significant.

Conclusions
The prevalence of LBP among Italian amateur cyclists seems to be less frequent compared to the general population. Moreover, undergoing previous specific pedal training and being supervised by a coach or following scheduled training drew a negative association with LBP development. This evidence highlights the importance of being overseen by specific sport figures that could offer a tailored evidence-based training to reach good physical level and to practise sports safely.