bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation functions and quantum measures of descendant states
Authors: Brehm Enrico M. , Broccoli Matteo 
Published: April 2021

Abstract
We discuss a computer implementation of a recursive formula to calculate correlation functions of descendant states in two-dimensional CFT. This allows us to obtain any N-point function of vacuum descendants, or to express the correlator as a differential operator acting on the respective primary correlator in case of non-vacuum descendants. With this tool at hand, we then study some entanglement and distinguishability measures between descendant states, namely the Rényi entropy, trace square distance and sandwiched Rényi divergence. Our results provide a test of the conjectured Rényi QNEC and new tools to analyse the holographic description of descendant states at large c.
Slaughter pigs as carrier of Listeria monocytogenes in Germany
Authors: Oswaldi Verena , Dzierzon Janine , Thieme Susann , Merle Roswitha , Meemken Diana 
Published: April 2021

AbstractListeria (L.) monocytogenes as the cause of human listeriosis is widespread in the environment and a hazard considering food safety. Almost all animal species as well as humans can be asymptomatic carriers of this bacterium. In pigs, the tonsils are identified as the organ with the highest detection rate compared to other sample matrices. We sampled 430 pigs in total in two slaughterhouses in Northwest and East Germany, two structurally different and important regions in pig production, to re-examine pigs as a possible source of Listeria-contamination of pork products. We detected a low prevalence of L. monocytogenes in tonsil samples of 1.6% (7/430) on single animal level and of 11.6% (5/43) on herd level with no significant difference between the two German regions. Apart from L. monocytogenes, the usually non-pathogenic L. innocua had a prevalence of 1.2% (5/430) on single animal level. From 200 pigs from Northwest Germany, intestinal content samples were analysed in addition to tonsil samples from the same animals, but no positive sample was found for L. monocytogenes (0.0%, 0/200), while four pigs were positive for L. innocua (2.0%, 4/200). Although the prevalence of L. monocytogenes in tonsils is low, the risk of cross-contaminating meat with the pathogen is still given.
Focused ultrasound radiosensitizes human cancer cells by enhancement of DNA damage
Authors: Zhang Xinrui , Bobeica Mariana , Unger Michael , Bednarz Anastasia , Gerold Bjoern , Patties Ina , Melzer Andreas , Landgraf Lisa 
Published: April 2021

Abstract
Purpose
High-intensity focused ultrasound (HIFU/FUS) has expanded as a noninvasive quantifiable option for hyperthermia (HT). HT in a temperature range of 40–47 °C (thermal dose CEM43 ≥ 25) could work as a sensitizer to radiation therapy (RT). Here, we attempted to understand the tumor radiosensitization effect at the cellular level after a combination treatment of FUS+RT.

Methods
An in vitro FUS system was developed to induce HT at frequencies of 1.147 and 1.467 MHz. Human head and neck cancer (FaDU), glioblastoma (T98G), and prostate cancer (PC-3) cells were exposed to FUS in ultrasound-penetrable 96-well plates followed by single-dose X‑ray irradiation (10 Gy). Radiosensitizing effects of FUS were investigated by cell metabolic activity (WST‑1 assay), apoptosis (annexin V assay, sub-G1 assay), cell cycle phases (propidium iodide staining), and DNA double-strand breaks (γH2A.X assay).

Results
The FUS intensities of 213 (1.147 MHz) and 225 W/cm2 (1.467 MHz) induced HT for 30 min at mean temperatures of 45.20 ± 2.29 °C (CEM43 = 436 ± 88) and 45.59 ± 1.65 °C (CEM43 = 447 ± 79), respectively. FUS improves the effect of RT significantly by reducing metabolic activity in T98G cells 48 h (RT: 96.47 ± 8.29%; FUS+RT: 79.38 ± 14.93%; p = 0.012) and in PC-3 cells 72 h (54.20 ± 10.85%; 41.01 ± 11.17%; p = 0.016) after therapy, but not in FaDu cells. Mechanistically, FUS+RT leads to increased apoptosis and enhancement of DNA double-strand breaks compared to RT alone in T98G and PC-3 cells.

Conclusion
Our in vitro findings demonstrate that FUS has good potential to sensitize glioblastoma and prostate cancer cells to RT by mainly enhancing DNA damage.
Frühkindliche Karies und Untergewicht
Authors: Wölfle U. C. , Hickel R. , Kühnisch J. 
Published: April 2021

ZusammenfassungFrühkindliche Karies gehört zu den prävalenten Erkrankungen des Kindesalters. Ursächlich kann neben frequenter Zufuhr kariogener Getränke und Lebensmittel ein häufiges, prolongiertes Stillen sein. Zusätzlich führt ausschließliches Stillen über das erste Lebenshalbjahr hinaus zu einer Mangelversorgung. Im vorliegenden Fall wird ein 2-jähriges Kind mit frühkindlicher Karies (ECC Typ II) und erheblichem Untergewicht vorgestellt, welches ausschließlich gestillt wurde. Eine Zahnsanierung in Allgemeinanästhesie mit begleitender Ernährungsumstellung führte zur Normalisierung des Körpergewichts.
On the ~ 7 year periodic signal in length of day from a frequency domain stepwise regression method
Authors: Hsu Can-Can , Duan Peng-Shuo , Xu Xue-Qing , Zhou Yong-Hong , Huang Cheng-Li 
Published: April 2021

AbstractThe intradecadal variations in length-of-day (LOD) and their time-varying characteristics still need to be further studied. Given that the corresponding signal periods on the intradecadal scales are quite close to each other and the span of currently observed ΔLOD data (i.e., 1962–2019, only 57 years) is not long enough, accurate detection of these signals depends on using effective mathematical method. On the basis of the traditional harmonic retrieval model, this work proposes a frequency domain stepwise regression method, which can well identify the periodic components with close periods and recognize the weaker signals to estimate the relevant harmonic parameters (i.e., amplitude, frequency and phase). Furthermore, we apply this method to detection of the actual LOD intradecadal variations, the result of which shows that there are three components (i.e., the ~ 5.9 years, ~ 8.3 years and ~ 7.3 years) existing in LOD intradecadal variations. Here, we firstly give the time-domain harmonic expression of the ~ 7.3 years signal, i.e., $$y\left(t\right)=A\mathrm{cos}\left(\frac{2\pi }{T}\left(t-1962+\psi \right)\right)$$

y

t

=
A
cos

2
π

T

t
-
1962
+
ψ

, where the period $$T=7.33$$

T
=
7.33

years, amplitude $$A=0.0413(\pm 0.0099)$$

A
=
0.0413
(
±
0.0099
)

ms, phase $$\psi =-1.58(\pm 0.30)$$

ψ
=
-
1.58
(
±
0.30
)

years. The mechanism of this ~ 7.3 years signal needs to be further studied.
Strain-specific interaction of Fructilactobacillus sanfranciscensis with yeasts in the sourdough fermentation
Authors: Rogalski Esther , Ehrmann Matthias A. , Vogel Rudi F. 
Published: April 2021

AbstractFructilactobacillus (F.) sanfranciscensis is a key bacterium in traditional (type 1) sourdough fermentations. It typically occurs in combination with the sourdough yeast Kazachstania (K.) humilis or the generalist Saccharomyces (S.) cerevisiae. Previous studies revealed intra-species diversity in competitiveness or dominance in sourdoughs of F. sanfranciscensis, as well as preferences for a life with or without a specific yeast. In this study representative, differently behaving strains were studied in media with different sugars and electron acceptors, and in rye sourdough fermentations in the presence and absence of K. humilis or S. cerevisiae. Strain-specific differences were observed in sugar and organic acids spectra in media, and in sourdoughs with F. sanfranciscensis strains in combination with K. humilis or S. cerevisiae. F. sanfranciscensis TMW 1.1150 proved dominant in the presence and absence of any yeast because it most effectively used maltose. Its maltose fermentation was unaffected by electron acceptors. F. sanfranciscensis TMW 1.2138 was the weakest maltose fermenter and incapable of glucose fermentation, and evidently not competitive against the other strains. F. sanfranciscensis TMW 1.392 was the most versatile strain regarding the utilization of different carbohydrates and its ability to exploit electron acceptors like fructose and oxygen. In sourdoughs without yeasts, it outcompeted other strains. The metabolism of F. sanfranciscensis TMW 1.907 was stimulated in combination with S. cerevisiae. In competitive trials, it was assertive only with S. cerevisiae. The intra-species differences in carbohydrate metabolism can widely explain the differences in their behavior in sourdough fermentation. Interaction between F. sanfranciscensis and the yeasts was strain specific and supposedly commensal with K. humilis and rather competitive with S. cerevisiae.
Evaluation of a curved surgical prototype in a human larynx
Authors: Schild L. R. , Boehm F. , Kienle L. , Seitz A. , Kahrs L. A. , Boeckers T. M. , Greve J. , Hoffmann T. K. , Schuler P. J. 
Published: April 2021

Abstract
Purpose
It is not always possible to create linear access to the larynx using a rigid operating laryngoscope for microlaryngoscopy. In this study, we evaluate the usability of a novel curved surgical prototype with flexible instruments for the larynx (sMAC) in a simulation dummy and human body donor.

Methods
In a user study (n = 6), head and neck surgeons as well as medical students tested the system for visualization quality and accessibility of laryngeal landmarks on an intubation dummy and human cadaver. A biopsy of the epiglottis was taken from the body donor. Photographic and time documentation was carried out.

Results
The sMAC system demonstrated general feasibility for laryngeal surgery. Unlike conventional microlaryngoscopy, all landmarks could be visualized and manipulated in both setups. Biopsy removal was possible. Visibility of the surgical field remained largely unobstructed even with an endotracheal tube in place. Overall handling of the sMAC prototype was satisfactorily feasible at all times.

Conclusion
The sMAC system could offer an alternative for patients, where microlaryngoscopy is not applicable. A clinical trial has to clarify if the system benefits in clinical routine.
Hormone replacement therapy in BRCA mutation carriers and risk of ovarian, endometrial, and breast cancer: a systematic review
Authors: Huber D. , Seitz S. , Kast K. , Emons G. , Ortmann O. 
Published: April 2021

Abstract
Purpose
BRCA mutation carriers have an increased risk of developing breast or ovarian cancer. Risk-reducing bilateral salpingo-oophorectomy (RRBSO) is associated with a decrease in risk for tubal and ovarian cancer. Hormone replacement therapy (HRT) may increase breast, ovarian, and endometrial cancer risk in the general population. This review analyses the published data on HRT and risk of cancer in BRCA mutation carriers with and without RRBSO.

Methods
We included all relevant articles published in English from 1995 to October 2020. Sources were identified through a search on PubMed and Cochrane Library.

Results
We included one case–control and one retrospective cohort study on ovarian and one case–control study on endometrial cancer risk and HRT in BRCA mutation carriers. Regarding breast cancer risk, one case–control study on BRCA mutation carriers with and without RRBSO and one case–control study, one Markov chain decision model, two prospective cohort studies, and one metaanalysis on carriers after RRBSO were included. For ovarian cancer, results were ambiguous. For breast cancer, most studies did not find an adverse effect associated with HRT. However, some of the studies found a risk modification associated with different formulations and duration of use.

Conclusion
Although data are limited, HRT does not seem to have a relevant effect on cancer risk in BRCA mutation carriers. RRBSO should not be postponed to avoid subsequent HRT in this population. Adequate HRT after RRBSO should be offered to avoid chronic diseases resulting from low estrogen levels. However, further data on the safety of different formulations are needed.
Deutungen: eine qualitative Studie unmittelbarer Patientenreaktionen
Authors: Firmansyah Dennis , Mergel Kai , Benecke Cord , Huber Dorothea , Grimm Imke , Klug Günther , Henkel Miriam 
Published: April 2021

ZusammenfassungKlassische psychoanalytische Deutungen stießen in den letzten Jahren vermehrt auf Kritik: Demnach würden diese Deutungen der therapeutischen Beziehung schaden, Blockaden auslösen und mit einer problematischen therapeutischen Haltung einhergehen. Anhand der Tonbandaufnahmen von 35 psychoanalytischen Sitzungen im mittleren Behandlungsverlauf, die im Rahmen der Münchner Psychotherapiestudie aufgezeichnet wurden, wurden 23 klassische Deutungen in 16 Sitzungen identifiziert und die Reaktionen der Patientinnen und Patienten darauf mittels der Grounded-Theory-Methode analysiert. Die Reaktionen wurden in sieben Kategorien zusammengefasst, von denen zwei als unerwünscht gelten können (z. B. „Rückzug“ oder „Konfrontation“). Die Mehrzahl der Reaktionen der Patientinnen und Patienten auf klassische Deutungen fiel allerdings in Kategorien, die als fruchtbar angesehen werden, z. B. „kognitive Erkenntnis“ oder „emotionale Resonanz“. Demnach kann die teils heftige Kritik an klassischen Deutungen in unserer Studie nicht bestätigt werden.
Peridynamic analysis of dynamic fracture: influence of peridynamic horizon, dimensionality and specimen size
Authors: Butt Sahir N. , Meschke Günther 
Published: April 2021

AbstractIn peridynamic models for fracture, the dissipated fracture energy is regularized over a non-local region denoted as the peridynamic horizon. This paper investigates the influence of this parameter on the dynamic fracture process in brittle solids, using two as well as three dimensional simulations of dynamic fracture propagation in a notched plate for two loading cases. The predicted crack speed for the various scenarios of the initially stored energy, also known as the velocity toughening behavior as well as characteristics of the crack surface topology obtained in different crack propagation regimes in 3D computational simulations are compared with the experimentally observed crack velocity and fracture surfaces for Polymethyl Methacrylate (PMMA) specimens. In addition, we investigate the influence of the specimen size on the dynamic fracture process using two dimensional peridynamic simulations. The fracture strengths and the velocity toughening relationship obtained from different specimen sizes are compared with the Linear Elastic Fracture Mechanics (LEFM) size effect relationship and with results from experiments, respectively.
Szenariobasierte Analyse der Kurzschlussströme im deutschen Niederspannungsnetz unter Verwendung der CIGRE-Referenznetze
Authors: Plenz Maik , Grumm Florian , Meyer Marc Florian , Boden Scott , Schulz Detlef , Lehmann Kathrin 
Published: April 2021

ZusammenfassungDie fortlaufenden, regulatorischen Eingriffe der Bundesregierung im Bereich erneuerbarer Energien führen zu einem hohen Anteil an Windkraft und Photovoltaikanlagen im elektrischen Energieversorgungssystem. Neben einer bevorzugten Einspeisung der erneuerbaren Energien erfolgt aktuell und zukünftig ein Rückbau oder die Stilllegung konventioneller Kraftwerke, wie Atom- und Kohlekraftwerke. Als quantitativer Bewertungsparameter zur Abschätzung der potenziellen Konsequenzen wird die Kurzschlussimpedanz verwendet, die aus den Kurzschlussströmen ableitbar ist. Die Kurzschlussimpedanz dient beispielsweise zur Bewertung der Aufnahmekapazität der Netzanschlusspunkte, der Sicherstellung der Versorgungsqualität und der Reduktion der Netzrückwirkungen. Die Impedanz eines Netzverknüpfungspunktes einer Anlage berechnet sich aus Netzkurzschlussleistung und der Netznennspannung. Somit ist die Netzkurzschlussleistung ein wesentlicher Parameter der Netzbewertung, der sich durch die Energiewende verändert. Betrachtet wird in diesem Beitrag der Anfangs-Kurzschlusswechselstrom, der die Grundlage für die rechnerische Größe der Netzkurzschlussleistung ist.Dieser Beitrag analysiert den Einfluss der Veränderung der Kurzschlussströme auf die Niederspannung (NS) unter Verwendung von Referenznetzen der Nieder- und Mittelspannungsebene (MS), szenariobasierten Simulationen und vereinfachten Modellen für erneuerbare Energieanlagen.Gleichzeitig werden bisherige Forschungsergebnisse auf Tendenzen untersucht, die die Veränderungen der Kurzschlussströme und den Einfluss von EE-Anlagen analysieren. Die Ergebnisse der Simulationen zeigen, dass die Kurzschlussströme trotz der Abschaltung von Großkraftwerken, die bisher durch Synchrongeneratoren den größten Anteil am Netzkurzschlussstrom lieferten, nicht in relevantem Maße abnehmen.
Recall, perceptions and determinants of receiving physical activity advice amongst cancer survivors: a mixed-methods survey
Authors: Orange Samuel T. , Gilbert Stephen E. , Brown Morven C. , Saxton John M. 
Published: April 2021

Abstract
Purpose
This study explored cancer survivors’ views and experiences of receiving physical activity advice post-diagnosis. We also determined the influence of sociodemographic characteristics on the recall of physical activity advice and whether receiving advice was associated with meeting physical activity guidelines.

Methods
An anonymised, mixed-methods, 27-item survey was distributed to cancer survivors via online cancer communities in the UK.

Results
Of the 242 respondents, 52% recalled receiving physical activity advice. Of those who recalled receiving advice, only 30% received guidance on type of physical activity and 14% were referred to another source of information or exercise specialist. Advice was most often given after treatment cessation, with only 19% of respondents receiving advice during active treatment. Most respondents (56%) expressed a need for further information. There was no evidence of associations between sociodemographic characteristics and recall of physical activity advice. However, cancer survivors who perceived the physical activity advice they received as being appropriate (odds ratio [OR] 3.8, 95% confidence interval [95% CI]: 1.4–10.7) and those with a higher level of education (OR 3.2, 95% CI: 1.8–5.8) were more likely to meet aerobic exercise guidelines. Females were less likely to meet resistance exercise guidelines than males (OR 0.44, 95% CI: 0.21–0.90).

Conclusion
There is scope to improve the provision of physical activity advice in cancer care by providing advice in a timely manner after diagnosis, referring patients to a suitable exercise or rehabilitation specialist when indicated, and using a tailored approach to ensure the advice is appropriate for specific sociodemographic groups.
Compaction control on diagenesis and reservoir quality development in red bed sandstones: a case study of Permian Rotliegend sandstones
Authors: Monsees Alexander C. , Busch Benjamin , Hilgers Christoph 
Published: April 2021

AbstractAuthigenic minerals formed during diagenesis in conjunction with compaction by burial have long been known to lead to porosity-loss of sandstones, and a subsequent deterioration in reservoir quality. The diagenetic impact on reservoir quality and permeability heterogeneity measured horizontal and vertical to bedding was characterized in three fluvio-eolian Lower Permian Rotliegend outcrops from the Flechtingen High, the northern Hesse Basin (both Germany) and the Vale of Eden (UK) using point-counting, polarized light-microscopy, helium pycnometry and permeability measurements. Results show significant porosity (10 to 35%) and permeability (0.01 to 10,000 mD) ranges largely independent of depositional environment. The major control on reservoir quality in Cornberg Sandstones are dolomite and siderite cementation in conjunction with illitization and illite and kaolinite cementation, leading together with quartz cementation to a mostly cemented IGV and poorest reservoir quality (avg. horizontal permeability: 0.96 mD). Flechtingen Sandstones are most intensely compacted due to the lack of significant early diagenetic cement phases and continuous illitic grain-to-grain coatings, which inhibited intense quartz cementation but enhanced chemical compaction at quartz grain contacts, resulting in intermediate reservoir quality (avg. horizontal permeability: 34.9 mD). Penrith Sandstones lack significant authigenic phases besides quartz due to carbonate dissolution during uplift. They show the least amount of detrital feldspars and clay minerals, leading to no major reservoir quality reduction by burial diagenetic clay mineral alterations, resulting in the highest reservoir quality (avg. horizontal permeability: 5900 mD). Additional results highlight higher horizontal to vertical permeability ratios kh/kv in less homogeneous sandstones of < 10 mD of 10, and in more homogenous, higher permeable sandstones > 1000 mD of 1. Although detrital and authigenic sample compositions vary throughout the studied areas, the general effect of grain coatings coverages on syntaxial cement inhibition and chemical compaction can be delineated. This study increases the understanding of porosity reduction in sandstones, as it confirms the necessity to differentiate between the illitic grain-to-grain coatings and illitic grain-to-IGV coatings. As a result, the enhancing effect of illite on chemical compaction on quartz grain-grain boundaries can be better constrained, as well as the effect of grain coatings on quartz cementation. This is relevant for reservoir quality and risk assessment in hydrocarbon and geothermal plays as well as in storage.
Peritoneal flap hernioplasty for repair of incisional hernias after orthotopic liver transplantation
Authors: Nielsen M. F. , de Beaux A. , Stutchfield B. , Kung J. , Wigmore S. J. , Tulloh B. 
Published: April 2021

Abstract
Background
Repair of incisional hernias following orthotopic liver transplantation (OLT) is a surgical challenge due to concurrent midline and transverse abdominal wall defects in the context of lifelong immunosuppression. The peritoneal flap hernioplasty addresses this problem by using flaps of the hernial sac to bridge the fascial gap and isolate the mesh from both the intraperitoneal contents and the subcutaneous space, exploiting the retro-rectus space medially and the avascular plane between the internal and external oblique muscles laterally. We report our short and long-term results of 26 consecutive liver transplant cases with incisional hernias undergoing repair with the peritoneal flap technique.

Methods
Post-OLT patients undergoing elective peritoneal flap hernioplasty for incisional hernias from Jan 1, 2010–Nov 1, 2017 were identified from the Lothian Surgical Audit system (LSA), a prospectively-maintained computer database of all surgical procedures in the Edinburgh region of south-east Scotland. Patient demographics and clinical data were obtained from the hospital case-notes. Follow-up data were obtained in Feb 2020.

Results
A total of 517 liver transplantations were performed during the inclusion period. Twenty-six of these (18 males, 69%) developed an incisional hernia and underwent a peritoneal flap repair. Median mesh size (Optilene Elastic, 48 g/m2, BBraun) was 900 cm2 (range 225–1500 cm2). The median time to repair following OLT was 33 months (range 12–70 months). Median follow-up was 54 months (range 24–115 months) and median postoperative stay was 5 days (range 3–11 days). Altogether, three patients (12%) presented with postoperative complications: 1 with hematoma (4%) and two with chronic pain (8%). No episodes of infection or symptomatic seroma were recorded. No recurrence was recorded within the follow-up period.

Conclusion
Repair of incisional hernias in patients following liver transplantation with the Peritoneal Flap Hernioplasty is a safe procedure associated with few complications and a very low recurrence rate. We propose this technique for the reconstruction of incisional hernias following liver transplantation.