bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with hip pain in end-stage renal disease patients on prevalent hemodialysis: a cross-sectional study
Authors: Şenlikci Hüma Bölük , Afşar Sevgi İkbali , Özen Selin , Sayın Cihat Burak 
Published: July 2021

Abstract
Background
Hemodialysis (HD) patients suffer from musculoskeletal disorders. The most reported musculoskeletal problem is arthralgia. Hip arthralgia has been commonly reported in patients undergoing HD. Hip pain can lead to a decrease in levels of physical activity, limitation in joint range of motion, and consequently difficulties in performing activities of daily living (ADL) and impair the quality of life (QoL). The aim of the study is to reveal the prevalence of hip pain and related factors in HD patients. This cross-sectional study included 73 patients on prevalent HD whose ages ranged from 25 to 65 years and who were on HD for more than 6 months. Physical examination and radiological imaging were done to every patient. Visual analog scale, Barthel Index, and Short Form-36 were used to evaluate pain, ADL, and QoL, respectively.

Results
Hip arthralgia was detected in 32 patients. Around 43% of which were diagnosed hip osteoarthritis, 34% greater trochanteric pain syndrome, 15% femoroacetabular impingement, and 6% soft tissue calcifications. Diabetes mellitus and hemodialysis duration were found to be significantly different between the groups of hip pain and without hip pain. Diabetes mellitus was identified as an independent risk factor for hip pain in hemodialysis patients. ADL and QoL were significantly lower in patients with hip pain compared to those without (p < 0.01; p < 0.05, respectively).

Conclusions
The results of our research show that HD patients should be screened for the presence of hip pain and other musculoskeletal disorders and that this is an area which requires further consideration and medical research.
Clinical Utility of Precision Medicine in Pediatric Oncology: A Systematic Review
Authors: Lee Justin , Gillam Lynn , Visvanathan Keshini , Hansford Jordan R. , McCarthy Maria C. 
Published: July 2021

PURPOSEPrecision medicine uses advanced molecular techniques to guide the use of targeted therapeutic drugs and is an emerging paradigm in pediatric oncology. Clinical evidence related to the efficacy of many novel targeted drugs, however, is currently very limited given the rarity of pediatric cancer and the lack of published evidence for the use of these drugs in children. This systematic review aimed to evaluate the existing evidence for the feasibility and clinical efficacy of precision medicine in pediatric oncology.METHODSA systematic review was conducted using the PubMed, Medline, and Embase databases. Clinical trials and observational studies, which used molecular assays such as whole-exome sequencing to identify molecular targets that guided the allocation of targeted cancer drugs and reported clinical outcomes, were included in this review.RESULTSTwenty-one clinical trials and observational studies were identified, collectively enrolling 1,408 pediatric patients across nine countries. Therapeutic targets were found in 647 patients (46.0%); however, only 175 of these patients (27.0%) received a targeted drug. Objective responses were recorded for 73 (41.7%) of these 175 patients, only 5.2% of the total sample. Inconsistent outcome reporting and limited comparison with conventional treatment hindered evaluation of the clinical utility of precision medicine.CONCLUSIONPrecision medicine can feasibly identify molecular targets in a clinical setting. However, the inaccessibility of targeted drugs is a significant barrier, restricting the exploration of its therapeutic potential in pediatric oncology. Future clinical trials should endeavor to link the molecular testing results with access to targeted drugs and standardize outcome reporting to advance understanding of the benefits of this novel paradigm in improving patient outcomes.
Progress
Authors: Chrostowska S. D. 
Published: July 2021

AbstractThis article begins from the assumption that what was once an integral dimension of progress—the development of literature and of art more generally—now lies outside its scope. The essay falls into three parts that juxtapose French with German intellectual history. The first part examines the notion of literary progress developed by Charles Perrault and Fontenelle, as well as the opposition to it by Boileau and other antiquarians, during the querelle des Anciens et des Modernes in the later seventeenth century. The second part treats the reception of those arguments during the eighteenth century by J. C. Gottsched, J. J. Bodmer, and J. J. Breitinger. Special attention is given to the paradox that Gottsched, the leader of the German antiquarians, and Bodmer, the leader of the German progressives, were equally devoted to the Leibnizian-Wolffian philosophical system and thus that German Romanticism, heavily indebted to Bodmer's poetics, had roots in rationalist philosophy. The essay's third part discusses ideas of literary progress in the writings of the early Romantics J. G. Herder and Friedrich Schlegel. As these discussions show, the conception of general progress was formed in a field that has since dissociated itself from progress's march.
miR-8b is involved in brain and eye regeneration ofDugesia japonicain head regeneration
Authors: Liu Hongjin , Song Qian , Zhen Hui , Deng Hongkuan , Zhao Bosheng , Cao Zhonghong 
Published: July 2021

ABSTRACTMicroRNAs (miRNAs) are a class of evolutionarily conserved small non-coding RNAs that regulate gene expression at the translation level in cell growth, proliferation and differentiation. In addition, some types of miRNAs have been proven to be key modulators of both CNS development and plasticity, such as let-7, miR-9 and miR-124. In this research, we found miR-8b acts as an important regulator involved in brain and eyespot regeneration in Dugesia japonica. miR-8b was highly conserved among species and was abundantly expressed in central nervous system. Here, we detected the expression dynamics of miR-8b by qPCR during the head regeneration of D. japonica. Knockdown miR-8b by anti-MIRs method caused severe defects of eyes and CNS. Our study revealed the evolutionary conserved role of miR-8b in the planarian regeneration process, and further provided more research ideas and available information for planarian miRNAs.
Auxin treatment increases lifespan in Caenorhabditis elegans
Authors: Loose Julia A. , Ghazi Arjumand 
Published: July 2021

ABSTRACT
The auxin-inducible degradation system (AID) has proven to be a highly versatile technology for rapid, robust and reversible depletion of proteins in multiple model systems. In recent years, AID has been adapted into the nematode Caenorhabditis elegans as a tool for conditional protein knockdown. Numerous transgenic strains have been created that, upon auxin exposure, undergo protein inactivation in the worm germline or somatic tissues, both during development and in young adults. Since longevity assays often involve long-term gene- and protein-manipulation, the facility for spatiotemporally precise and extended protein removal makes AID a potentially highly valuable tool for aging biology. However, whether auxins themselves impact worm longevity has not been directly addressed. Here, we show that prolonged exposure to indole 3-acetic acid (IAA), the auxin used in worm AID studies, extends lifespan. We also report that two transgenic strains expressing Arabidopsis proteins that are key components of the AID platform are longer lived than wild-type animals. Together, our results highlight the necessity for exercising caution while utilizing AID for longevity studies and in interpreting the resulting data.
This article has an associated First Person interview with the first author of the paper.
APC/CFZR-1 regulates centrosomal ZYG-1 to limit centrosome number
Authors: Medley Jeffrey C. , DiPanni Joseph R. , Schira Luke , Shaffou Blake M. , Sebou Brandon M. , Song Mi Hye 
Published: July 2021

ABSTRACTAberrant centrosome numbers are associated with human cancers. The levels of centrosome regulators positively correlate with centrosome number. Thus, tight control of centrosome protein levels is critical. In Caenorhabditis elegans, the anaphase-promoting complex/cyclosome and its co-activator FZR-1 (APC/CFZR-1), a ubiquitin ligase, negatively regulates centrosome assembly through SAS-5 degradation. In this study, we report the C. elegans ZYG-1 (Plk4 in humans) as a potential substrate of APC/CFZR-1. Inhibiting APC/CFZR-1 or mutating a ZYG-1 destruction (D)-box leads to elevated ZYG-1 levels at centrosomes, restoring bipolar spindles and embryonic viability to zyg-1 mutants, suggesting that APC/CFZR-1 influences centrosomal ZYG-1 via the D-box motif. We also show the Slimb/βTrCP-binding (SB) motif is critical for ZYG-1 degradation, substantiating a conserved mechanism by which ZYG-1/Plk4 stability is regulated by the SKP1–CUL1–F-box (Slimb/βTrCP)-protein complex (SCFSlimb/βTrCP)-dependent proteolysis via the conserved SB motif in C. elegans. Furthermore, we show that co-mutating ZYG-1 SB and D-box motifs stabilizes ZYG-1 in an additive manner, suggesting that the APC/CFZR-1 and SCFSlimb/βTrCP ubiquitin ligases function cooperatively for timely ZYG-1 destruction in C. elegans embryos where ZYG-1 activity remains at threshold level to ensure normal centrosome number.
The role of load-dependent sensory input in the control of balance during gait in rats
Authors: Popov Alexander , Lyakhovetskii Vsevolod , Bazhenova Elena , Gorskii Oleg , Kalinina Daria , Merkulyeva Natalia , Musienko Pavel 
Published: July 2021

ABSTRACTLocomotor activity requires fine balance control that strongly depends on the afferent input from the load receptors. Following hindlimb unloading (HU), the kinematic and EMG activity of the hindlimbs is known to change significantly. However, the effects of HU on the integrative control mechanisms of posture and locomotion are not clear. The goal of the present study was to evaluate the center of mass (CoM) dynamic stabilization and associated adaptive changes in the trunk and hindlimb muscle activity during locomotion after 7 days of HU. The EMG signals from the muscles of the low lumbar trunk [m. longissimus dorsi (VERT)] and the hind limb [m. tibialis anterior (TA), m. semitendinosus (ST), m. soleus (SOL)] were recorded together with the hindquarter kinematics during locomotion on a treadmill in six rats before and after HU. The CoM lateral shift in the step cycle significantly increased after HU and coincided with the enhanced activity of the VERT. The mean EMG of the TA and the ST flexor activity increased significantly with reduction of their burst duration. These data demonstrate the disturbances of body balance after HU that can influence the basic parameters of locomotor activity. The load-dependent mechanisms resulted in compensatory adjustments of flexor activity toward a faster gait strategy, such as a trot or gallop, which presumably have supraspinal origin. The neuronal underpinnings of these integrative posture and locomotion mechanisms and their possible reorganization after HU are discussed.
Aerial course stabilization is impaired in motion-blind flies
Authors: Leonte Maria-Bianca , Leonhardt Aljoscha , Borst Alexander , Mauss Alex S. 
Published: July 2021

ABSTRACT
Visual motion detection is among the best understood neuronal computations. As extensively investigated in tethered flies, visual motion signals are assumed to be crucial to detect and counteract involuntary course deviations. During free flight, however, course changes are also signalled by other sensory systems. Therefore, it is as yet unclear to what extent motion vision contributes to course control. To address this question, we genetically rendered flies motion-blind by blocking their primary motion-sensitive neurons and quantified their free-flight performance. We found that such flies have difficulty maintaining a straight flight trajectory, much like unimpaired flies in the dark. By unilateral wing clipping, we generated an asymmetry in propulsive force and tested the ability of flies to compensate for this perturbation. While wild-type flies showed a remarkable level of compensation, motion-blind animals exhibited pronounced circling behaviour. Our results therefore directly confirm that motion vision is necessary to fly straight under realistic conditions.
Liver-First Approach for Synchronous Colorectal Metastases: Analysis of 7360 Patients from the LiverMetSurvey Registry
Authors: Giuliante Felice , Viganò Luca , De Rose Agostino M. , Mirza Darius F. , Lapointe Réal , Kaiser Gernot , Barroso Eduardo , Ferrero Alessandro , Isoniemi Helena , Lopez-Ben Santiago , Popescu Irinel , Ouellet Jean-Francois , Hubert Catherine , Regimbeau Jean-Marc , Lin Jen-Kou , Skipenko Oleg G. , Ardito Francesco , Adam René 
Published: July 2021

Abstract
Background
The liver-first approach in patients with synchronous colorectal liver metastases (CRLM) has gained wide consensus but its role is still to be clarified. We aimed to elucidate the outcome of the liver-first approach and to identify patients who benefit at most from this approach.

Methods
Patients with synchronous CRLM included in the LiverMetSurvey registry between 2000 and 2017 were considered. Three strategies were analyzed, i.e. liver-first approach, colorectal resection followed by liver resection (primary-first), and simultaneous resection, and three groups of patients were analyzed, i.e. solitary metastasis, multiple unilobar CRLM, and multiple bilobar CRLM. In each group, patients from the three strategy groups were matched by propensity score analysis.

Results
Overall, 7360 patients were analyzed: 4415 primary-first, 552 liver-first, and 2393 simultaneous resections. Compared with the other groups, the liver-first group had more rectal tumors (58.0% vs. 31.2%) and higher hepatic tumor burden (more than three CRLMs: 34.8% vs. 24.0%; size > 50 mm: 35.6% vs. 22.8%; p < 0.001). In patients with solitary and multiple unilobar CRLM, survival was similar regardless of treatment strategy, whereas in patients with multiple bilobar metastases, the liver-first approach was an independent positive prognostic factor, both in unmatched patients (3-year survival 65.9% vs. primary-first 60.4%: hazard ratio [HR] 1.321, p = 0.031; vs. simultaneous resections 54.4%: HR 1.624, p < 0.001) and after propensity score matching (vs. primary-first: HR 1.667, p = 0.017; vs. simultaneous resections: HR 2.278, p = 0.003).

Conclusion
In patients with synchronous CRLM, the surgical strategy should be decided according to the hepatic tumor burden. In the presence of multiple bilobar CRLM, the liver-first approach is associated with longer survival than the alternative approaches and should be evaluated as standard.
Delicate balance: the relationship between internal astigmatism and lens astigmatism
Authors: Liu Meng , Dai Cheng , Zhou Guimei , Lv Xiaodong , Li Jingjia , Li Binzhong 
Published: July 2021

Background: Due to lack of equipment for directly measuring crystal morphology, there has been little research on crystal astigmatism. The purpose of this study was to accurately explore the correlation between internal astigmatism and lens astigmatism in patients with ametropia. Methods: This is a cross-sectional study conducted in the Affiliated Hospital of North Sichuan Medical College, China, in September 2020. Diopter values (refractive astigmatism, RA) of patients with ametropia was recorded, and the corneal and lens biological parameters were measured by CASIA2 (corneal/anterior segment optical correlation tomography analyzer). Biometric parameters, including the total corneal astigmatism (TCA), anterior and posterior curvature radius of the lens (ACL, PCL), internal astigmatism (IA), anterior and posterior astigmatism of the lens (AAL, PAL) were measured. Grouping and comparisons were made according to gender and age. Results: In total, 151 participants (293 eyes) were included in the analysis. There were significant (P<0.05) differences in the IA (Z=-2.194, P=0.028) according to gender, but not in the other parameters. By age group, there were statistically significant differences in the TCA (H=10.609, P=0.005), IA (F=3.722, P=0.025), and PAL (H=8.254, P=0.016), but not in the others. The IA was positively correlated with the age (r=0.155, P=0.008), RA (r=0. 534, P<0.001), AAL (r=0.308, P<0.001), and was negatively correlated with the TCA (r=-0.244, P<0.001). The regression equation between the IA and AAL was: Y (IA) =-0.626 +0.447X (AAL). Conclusions: There is a delicate balance between internal astigmatism and intraocular astigmatism. There were no significant differences in the other parameters except IA for different gender groups. For different ages, there are symbol differences in the TCA, IA and PAL, but not in the other parameters. In the analysis of IA with lens astigmatism, it was found that internal astigmatism was mainly related to AAL, but not to PAL.
Public trust and genomic medicine in Canada and the UK
Authors: Savić-Kallesøe Sarah , Middleton Anna , Milne Richard 
Published: July 2021

Background: Genomic medicine could improve precise risk stratification, early prevention, and personalised treatment across a broad spectrum of disease. As this reality approaches, questions on the importance of public trust arise. The success of genomic medicine initiatives is influenced by the public’s trust and willingness to engage. Specific social actors influential in the public's trust have been identified by the “Your DNA, Your Say” study, including doctors, researchers, and governments. This paper aims to identify and examine which specific social actors, if any, in Canada and the United Kingdom (UK) are the most trustworthy and influential to engage the public in genomic medicine research. Methods: Using data from the ‘Your DNA, Your Say’ study, logistic regression models and Pearson’s chi-square tests were conducted to explore trust in social actors across Canada and the UK. Results: The results demonstrate Canada and the UK significantly differ in public trust and willingness to donate. Non-profit researchers, domestic doctors, and personal doctors were identified to be the most influential and trustworthy social actors in Canada and the UK. Conclusions: The comparative results indicate that both countries would benefit from engaging the public through doctors and non-profit researchers. The UK could additionally support public trust by engaging with the public through the National Health Service. However, the results suggest that whilst public trust is significant, it may be neither necessary nor sufficient in influencing willingness to donate. Future research could do well to investigate how the importance of public trust compares in countries with lower public trust.
Which Workers are Most Exposed to covid-19 and Social Distancing Effects in a Dual Labour Market?
Authors: Cardenas Jeisson , Montana Jaime , Bosworth David 
Published: July 2021

This paper provides evidence for the different potential effects of covid-19 on formal and informal employment, using the work-from-home (Dingel & Neiman, 2020; Saltiel, 2020) and the proximity occupation approaches (Mongey et al., 2020) in Colombia. We found that only 13 % of informal employment positions can be performed from home (remotely) and that the figure for formal employment is twice as large (20 %). We recoded the raw occupational responses of the Colombian Household Survey to a granular level to directlycombine occupational information from two sources: O*net and step. We then calculated work-from-home estimates, extracting cohesive results from both sources. We investigated how personal and household characteristics relate to work-from-home and proximity and provide sound evidence for a larger effect on the informal population and its association with vulnerability (lower income and education levels, no internet access, poorworking conditions). Standard employment policies will not impact directly on the most vulnerable populations in developing countries where informal employment is the norm.
Giving Away the Game – Scattershot Notes on Social Class and Other Afflictions
Authors: Donnelly Jim 
Published: July 2021

One of my earliest jobs was driving for an unregulated car service in New York. In the days before Uber they were called ‘gypsy cabs.’ One night I found myself on the business end of a revolver. Telling the tale to my dispatcher next day, he was staggeringly nonplussed. ‘Ya gotta put up with a lot,’ he said, ‘when you’re tryin’ t’ get ahead.’ ‘Yeah,’ I replied, disgusted, ‘even gettin’ your head blown off.’ Some time later, another driver, an African-American in a similar scenario, didn’t make it, emphasizing how much higher the stakes for a person of color. These are the real wages of work, I thought, and the rules of the game.
My dispatcher’s nonchalance bespoke how invested in the game he was; in a set of beliefs, assumptions, and animating myths that keep the wheel of fortune going. Like the Monty Python skit about the collapsing tower, if too few invest in those myths, the entire edifice crumbles.
The following is a personal essay that attempts to navigate the game’s parameters - social class, aspiration, and its attendant neurosis - and the myths that animate such notions as ‘getting ahead,’ ‘climbing the ladder,’ and the ‘American Dream,’ my country’s main (ideological) export. The approach is less theory-driven than empirical, phenomenological. Hence the numbered sections, a style popularized by Wittgenstein, Herbert Read and others. Here it doesn’t represent chronology so much as the elusive, episodic nature of the beast.
Cement-in-cement femoral component revision
Authors: Kennedy Ian W. , Ng Nigel Y. B. , Young David , Kane Nicholas , Marsh Andrew G. , Meek R. M. Dominic 
Published: July 2021

AimsCement-in-cement revision of the femoral component represents a widely practised technique for a variety of indications in revision total hip arthroplasty. In this study, we compare the clinical and radiological outcomes of two polished tapered femoral components.MethodsFrom our prospectively collated database, we identified all patients undergoing cement-in-cement revision from January 2005 to January 2013 who had a minimum of two years' follow-up. All cases were performed by the senior author using either an Exeter short revision stem or the C-Stem AMT high offset No. 1 prosthesis. Patients were followed-up annually with clinical and radiological assessment.ResultsA total of 97 patients matched the inclusion criteria (50 Exeter and 47 C-Stem AMT components). There were no significant differences between the patient demographic data in either group. Mean follow-up was 9.7 years. A significant improvement in Oxford Hip Score (OHS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and 12-item Short-Form Survey (SF-12) scores was observed in both cohorts. Leg lengths were significantly shorter in the Exeter group, with a mean of -4 mm in this cohort compared with 0 mm in the C-Stem AMT group. One patient in the Exeter group had early evidence of radiological loosening. In total, 16 patients (15%) underwent further revision of the femoral component (seven in the C-Stem AMT group and nine in the Exeter group). No femoral components were revised for aseptic loosening. There were two cases of femoral component fracture in the Exeter group.ConclusionOur series shows promising mid-term outcomes for the cement-in-cement revision technique using either the Exeter or C-Stem AMT components. These results demonstrate that cement-in-cement revision using a double or triple taper-slip design is a safe and reliable technique when used for the correct indications.Cite this article: Bone Joint J 2021;103-B(7):1215–1221.