bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research Integrated Network of Systems (RINS): a virtual data warehouse for the acceleration of translational research
Authors: He Wenjun , Kirchoff Katie G , Sampson Royce R , McGhee Kimberly K , Cates Andrew M , Obeid Jihad S , Lenert Leslie A 
Published: January 2021

Abstract

Objective
Integrated, real-time data are crucial to evaluate translational efforts to accelerate innovation into care. Too often, however, needed data are fragmented in disparate systems. The South Carolina Clinical & Translational Research Institute at the Medical University of South Carolina (MUSC) developed and implemented a universal study identifier—the Research Master Identifier (RMID)—for tracking research studies across disparate systems and a data warehouse-inspired model—the Research Integrated Network of Systems (RINS)—for integrating data from those systems.

Materials and Methods
In 2017, MUSC began requiring the use of RMIDs in informatics systems that support human subject studies. We developed a web-based tool to create RMIDs and application programming interfaces to synchronize research records and visualize linkages to protocols across systems. Selected data from these disparate systems were extracted and merged nightly into an enterprise data mart, and performance dashboards were created to monitor key translational processes.

Results
Within 4 years, 5513 RMIDs were created. Among these were 726 (13%) bridged systems needed to evaluate research study performance, and 982 (18%) linked to the electronic health records, enabling patient-level reporting.

Discussion
Barriers posed by data fragmentation to assessment of program impact have largely been eliminated at MUSC through the requirement for an RMID, its distribution via RINS to disparate systems, and mapping of system-level data to a single integrated data mart.

Conclusion
By applying data warehousing principles to federate data at the “study” level, the RINS project reduced data fragmentation and promoted research systems integration.
Two Complete Mitochondrial Genomes From Leuctridae (Plecoptera: Nemouroidea): Implications for the Phylogenetic Relationships Among Stoneflies
Authors: Cao Jinjun , Wang Ying , Guo Xuan , Wang Guoquan , Li Weihai , Murányi Dávid 
Published: January 2021

Abstract
The family-level relationships within Plecoptera have been a focused area of research for a long time. Its higher classification remains unstable, and the phylogenetic relationships within Plecoptera should be re-examined. Here, we sequenced and analyzed two complete mitochondrial genomes (mitogenomes) of Paraleuctra cercia and Perlomyia isobeae of the family Leuctridae. We reconstructed the phylogeny of Plecoptera based on 13 protein-coding genes (PCGs) from published stoneflies. Our results showed that the Bayesian inference and maximum-likelihood tree had similar topological structures except for the positions of two families, Peltoperlidae and Scopuridae. The Plecoptera is divided into two clades, the suborder Antarctoperlaria and the suborder Arctoperlaria. The two suborders subsequently formed two groups, Eusthenioidea and Gripopterygoidea, and Euholognatha and Systellognatha, which is consistent with the results of morphological studies. In addition, the Leuctridae is the earliest branch within the superfamily Nemouroidea. But the monophyly of Perloidea and Pteronarcyoidea are still not well supported.
Palliative brachytherapy and external beam radiotherapy for dysphagia from esophageal cancer: a nationwide survey in Japan
Authors: Kawamoto Terufumi , Nakamura Naoki , Saito Tetsuo , Tonari Ayako , Wada Hitoshi , Harada Hideyuki , Kubota Hikaru , Nagakura Hisayasu , Heianna Joichi , Miyazawa Kazunari , Yamada Kazunari , Tago Masao , Fushiki Masato , Nozaki Miwako , Uchida Nobue , Araki Norio , Sekii Shuhei , Kosugi Takashi , Takahashi Takeo , Shikama Naoto 
Published: January 2021

Abstract

Background
International guidelines recommend brachytherapy for patients with dysphagia from esophageal cancer, whereas brachytherapy is infrequently used to palliate dysphagia in some countries. To clarify the availability of palliative treatment for dysphagia from esophageal cancer and explain why brachytherapy is not routinely performed are unknown, this study investigated the use of brachytherapy and external beam radiotherapy for dysphagia from esophageal cancer.

Methods
Japanese Radiation Oncology Study Group members completed a survey and selected the treatment that they would recommend for hypothetical cases of dysphagia from esophageal cancer.

Results
Of the 136 invited facilities, 61 completed the survey (44.9%). Four (6.6%) facilities performed brachytherapy of the esophagus, whereas brachytherapy represented the first-line treatment at three (4.9%) facilities. Conversely, external beam radiotherapy alone and chemoradiotherapy were first-line treatments at 61 and 58 (95.1%) facilities, respectively. In facilities that performed brachytherapy, the main reason why brachytherapy of the esophagus was not performed was high invasiveness (30.2%). Definitive-dose chemoradiotherapy with (≥50 Gy) tended to be used in patients with expected long-term survival.

Conclusions
Few facilities routinely considered brachytherapy for the treatment of dysphagia from esophageal cancer in Japan. Conversely, most facilities routinely considered external beam radiotherapy. In the future, it will be necessary to optimize external beam radiotherapy.
How Are Disputes Resolved under Bilateral Air Services Agreements? A Typology
Authors: Zhang Luping 
Published: January 2021

Abstract
After a dispute between India and Pakistan broke out concerning overflight rights, the International Civil Aviation Organisation (ICAO) Secretariat reviewed 204 bilateral aeronautical agreements between 1941 and 1951 and listed them according to the categories of dispute resolution clauses that they contained. Around 68 years have passed and the ICAO Council has exercised its dispute settlement power in multiple occasions. This article builds upon the research carried out by the ICAO Secretariat, which it supplements with up-to-date data of 709 agreements. It then provides a typology, a study of different types, of bilateral air services agreements (ASAs). The article concludes that the use of international arbitration is the primary forum for dispute resolution chosen by drafters of bilateral ASAs. However, a look at the cases brought to ad hoc arbitration reveals deficiencies, which leads us to discuss potential institutionalized reforms.
Fluid–structure interaction simulation on flight performance of a dragonfly wing under different pterostigma weights
Authors: Chu Yung Jeh , Ganesan Poo Balan , Ali Mohamad Azlin 
Published: January 2021

AbstractThe dragonfly wings provide insights for designing an efficient biomimetic micro air vehicle (BMAV). In this regard, this study focuses on investigating the effect of the pterostigma weight loading and its spatial location on the forewings of dragonfly by using the fluid–structure interaction simulation. This study also investigates the effect of change in the wing elasticity and density on the wing performance. The forewing, which mimics the real dragonfly wing, is flat with a 47.5 mm span and a 0.4 mm thickness. The wing was set to cruise at 3 m/s with a constant flapping motion at a frequency of 25 Hz. This study shows that a small increase of pterostigma loading (11% of wing weight) at the tip of the wing significantly improves the lift to drag ratio, CL/CD, which has 129.16% increment in comparison with no loading. The lift to drag ratio depends on the pterostigma location, pterostigma loading, elastic modulus and density. The results of this study can be used as a reference in future BMAV wing optimization design.
Observations and spectral modelling of the narrow-lined Type Ic SN 2017ein
Authors: Teffs J J , Prentice S J , Mazzali P A , Ashall C 
Published: January 2021

ABSTRACT
SN 2017ein is a narrow-lined Type Ic SN that was found to share a location with a point-like source in the face on spiral galaxy NGC 3938 in pre-supernova images, making SN 2017ein the first credible detection of a Type Ic progenitor. Results in the literature suggest that this point-like source is likely a massive progenitor of 60–80 M⊙, depending on if the source is a binary, a single star, or a compact cluster. Using new photometric and spectral data collected for 200 d, including several nebular spectra, we generate a consistent model covering the photospheric and nebular phase using a Monte Carlo radiation transport code. Photospheric phase modelling finds an ejected mass 1.2–2.0 M⊙ with an Ek of ∼(0.9 ± 0.2) × 1051 erg, with approximately 1 M⊙ of material below 5000 km s−1 found from the nebular spectra. Both photospheric and nebular phase modelling suggests a 56Ni mass of 0.08–0.1 M⊙. Modelling the [O i] emission feature in the nebular spectra suggests that the innermost ejecta are asymmetric. The modelling results favour a low-mass progenitor of 16–20 M⊙, which is in disagreement with the pre-supernova derived high-mass progenitor. This contradiction is likely due to the pre-supernova source not representing the actual progenitor.
Structural basis for RNA recognition by the N-terminal tandem RRM domains of human RBM45
Authors: Chen Xiaolei , Yang Zhongmei , Wang Wenfeng , Qian Kaiyue , Liu Mingjie , Wang Junchao , Wang Mingzhu 
Published: January 2021

Abstract
RBM45 is an RNA-binding protein involved in neural development, whose aggregation is associated with neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD). However, the mechanisms of RNA-binding and aggregation of RBM45 remain unelucidated. Here, we report the crystal structure of the N-terminal tandem RRM domains of human RBM45 in complex with single-stranded DNA (ssDNA). Our structural and biochemical results revealed that both the RRM1 and RRM2 of RBM45 recognized the GAC sequence of RNA/ssDNA. Two aromatic residues and an arginine residue in each RRM were critical for RNA-binding, and the interdomain linker was also involved in RNA-binding. Two RRMs formed a pair of antiparallel RNA-binding sites, indicating that the N-terminal tandem RRM domains of RBM45 bound separate GAC motifs in one RNA strand or GAC motifs in different RNA strands. Our findings will be helpful in the identification of physiologic targets of RBM45 and provide evidence for understanding the physiologic and pathologic functions of RBM45.
Industry-Sponsored Research Payments in Neurosurgery—Analysis of the Open Payments Database From 2014 to 2018
Authors: Vanood Aimen , Sharrak Aryana , Karabon Patrick , Fahim Daniel K 
Published: January 2021

Abstract

BACKGROUND
The Open Payments Database (OPD) started in 2013 to combat financial conflicts of interest between physicians and medical industry.

OBJECTIVE
To evaluate the first 5 yr of the OPD regarding industry-sponsored research funding (ISRF) in neurosurgery.

METHODS
The Open Payments Research Payments dataset was examined from 2014 to 2018 for payments where the clinical primary investigator identified their specialty as neurosurgery.

RESULTS
Between 2014 and 2018, a $106.77 million in ISRF was made to 731 neurosurgeons. Fewer than 11% of neurosurgeons received ISRF yearly. The average received $140 000 in total but the median received $30,000. This was because the highest paid neurosurgeon received $3.56 million. A greater proportion ISRF was made to neurosurgeons affiliated with teaching institutions when compared to other specialties (26.74% vs 20.89%, P = .0021). The proportion of the total value of ISRF distributed to neurosurgery declined from 0.43% of payments to all specialties in 2014 to 0.37% in 2018 (P < .001), but no steady decline was observed from year to year.

CONCLUSION
ISRF to neurosurgeons comprises a small percentage of research payments made to medical research by industry sponsors. Although a greater percentage of payments are made to neurosurgeons in teaching institutions compared to other specialties, the majority is given to neurosurgeons not affiliated with a teaching institution. A significant percentage of ISRF is given to a small percentage of neurosurgeons. There may be opportunities for more neurosurgeons to engage in industry-sponsored research to advance our field as long as full and complete disclosures can always be made.
Impact of Coronavirus Disease 2019 on Infectious Diseases Fellows in the United States: Perspectives From the First National Infectious Diseases Fellows Call
Authors: Nematollahi Saman , Konold Victoria J L , Gaston David C , Howard-Anderson Jessica , Kiley John L , Masters Mary C , Melia Michael T , Balba Gayle P , Chiang Augusto Dulanto , Gupta Nupur 
Published: January 2021

AbstractThe coronavirus disease 2019 (COVID-19) pandemic has affected many providers, but its impact on Infectious Diseases (ID) fellows in the United States is largely undescribed. In this study, we discuss key issues that emerged from the first national ID Fellows Call with respect to the ID fellow’s role during the COVID-19 pandemic, teaching/learning, and research.
Professional Development for Industrial-Organizational Psychology Master’s Graduates
Authors: Shoenfelt Elizabeth L. 
Published: January 2021

Abstract
This chapter addresses the important postgraduate experience of continuing training and development for industrial-organizational (I-O) psychology master’s graduates. I-O master’s students often leave school with fewer networking ties, academic mentors, and overall skills in their toolbox than do PhD students. This chapter discusses common certifications and continuing education opportunities that are relevant to those pursuing I-O psychology careers. Mentoring experience are discussed based on experiences of I-O master’s graduates and their employers. Three best-practice suggestions for maximizing mentoring relationships are described. I-O psychology master’s practitioners should use professional development opportunities that increase their knowledge, skills, and the power of their résumé and that help advance their careers.
An atlas of wheat epigenetic regulatory elements reveals subgenome divergence in the regulation of development and stress responses
Authors: Wang Meiyue , Li Zijuan , Zhang Yu’e , Zhang Yuyun , Xie Yilin , Ye Luhuan , Zhuang Yili , Lin Kande , Zhao Fei , Guo Jingyu , Teng Wan , Zhang Wenli , Tong Yiping , Xue Yongbiao , Zhang Yijing 
Published: January 2021

Abstract
Wheat (Triticum aestivum) has a large allohexaploid genome. Subgenome-divergent regulation contributed to genome plasticity and the domestication of polyploid wheat. However, the specificity encoded in the wheat genome determining subgenome-divergent spatio-temporal regulation has been largely unexplored. The considerable size and complexity of the genome are major obstacles to dissecting the regulatory specificity. Here, we compared the epigenomes and transcriptomes from a large set of samples under diverse developmental and environmental conditions. Thousands of distal epigenetic regulatory elements (distal-epiREs) were specifically linked to their target promoters with coordinated epigenomic changes. We revealed that subgenome-divergent activity of homologous regulatory elements is affected by specific epigenetic signatures. Subgenome-divergent epiRE regulation of tissue specificity is associated with dynamic modulation of H3K27me3 mediated by Polycomb complex and demethylases. Furthermore, quantitative epigenomic approaches detected key stress responsive cis- and trans-acting factors validated by DNA Affinity Purification and sequencing, and demonstrated the coordinated interplay between epiRE sequence contexts, epigenetic factors, and transcription factors in regulating subgenome divergent transcriptional responses to external changes. Together, this study provides a wealth of resources for elucidating the epiRE regulomics and subgenome-divergent regulation in hexaploid wheat, and gives new clues for interpreting genetic and epigenetic interplay in regulating the benefits of polyploid wheat.
Predominantly inverse modulation of gene expression in genomically unbalanced disomic haploid maize
Authors: Yang Hua , Shi Xiaowen , Chen Chen , Hou Jie , Ji Tieming , Cheng Jianlin , Birchler James A 
Published: January 2021

Abstract
The phenotypic consequences of the addition or subtraction of part of a chromosome is more severe than changing the dosage of the whole genome. By crossing diploid trisomies to a haploid inducer, we identified 17 distal segmental haploid disomies that cover ∼80% of the maize genome. Disomic haploids provide a level of genomic imbalance that is not ordinarily achievable in multicellular eukaryotes, allowing the impact to be stronger and more easily studied. Transcriptome size estimates revealed that a few disomies inversely modulate most of the transcriptome. Based on RNA sequencing, the expression levels of genes located on the varied chromosome arms (cis) in disomies ranged from being proportional to chromosomal dosage (dosage effect) to showing dosage compensation with no expression change with dosage. For genes not located on the varied chromosome arm (trans), an obvious trans-acting effect can be observed, with the majority showing a decreased modulation (inverse effect). The extent of dosage compensation of varied cis genes correlates with the extent of trans inverse effects across the 17 genomic regions studied. The results also have implications for the role of stoichiometry in gene expression, the control of quantitative traits, and the evolution of dosage-sensitive genes.
Ethylene-regulated asymmetric growth of the petal base promotes flower opening in rose (Rosa hybrida)
Authors: Cheng Chenxia , Yu Qin , Wang Yaru , Wang Hong , Dong Yuhan , Ji Yuqi , Zhou Xiaofeng , Li Yonghong , Jiang Cai-Zhong , Gan Su-Sheng , Zhao Liangjun , Fei Zhangjun , Gao Junping , Ma Nan 
Published: January 2021

AbstractFlowers are the core reproductive structures and key distinguishing features of angiosperms. Flower opening to expose stamens and gynoecia is important in cases where pollinators much be attracted to promote cross-pollination, which can enhance reproductive success and species preservation. The floral opening process is accompanied by the coordinated movement of various floral organs, particularly petals. However, the mechanisms underlying petal movement and flower opening are not well understood. Here, we integrated anatomical, physiological, and molecular approaches to determine the petal movement regulatory network using rose (Rosa hybrida) as a model. We found that PETAL MOVEMENT-RELATED PROTEIN1 (RhPMP1), a homeodomain transcription factor (TF) gene, is a direct target of ETHYLENE INSENSITIVE3, a TF that functions downstream of ethylene signaling. RhPMP1 expression was upregulated by ethylene and specifically activated endoreduplication of parenchyma cells on the adaxial side of the petal (ADSP) base by inducing the expression of RhAPC3b, a gene encoding the core subunit of the Anaphase-Promoting Complex. Cell expansion of the parenchyma on the ADSP base was subsequently enhanced, thus resulting in asymmetric growth of the petal base, leading to the typical epinastic movement of petals and flower opening. These findings provide insights into the pathway regulating petal movement and associated flower-opening mechanisms.�
The receptor-like cytoplasmic kinase CDG1 negatively regulates Arabidopsis pattern-triggered immunity and is involved in AvrRpm1-induced RIN4 phosphorylation
Authors: Yang Qiujiao , Guo Jianhang , Zeng Hairuo , Xu Lahong , Xue Jiao , Xiao Shi , Li Jian-Feng 
Published: January 2021

Abstract
Arabidopsis CDG1 negatively regulates flg22- and chitin-triggered immunity by promoting FLS2 and CERK1 degradation and is partially required for bacterial effector AvrRpm1-induced RIN4 phosphorylation.
Negative regulators play indispensable roles in pattern-triggered immunity in plants by preventing sustained immunity impeding growth. Here, we report Arabidopsis thaliana CONSTITUTIVE DIFFERENTIAL GROWTH1 (CDG1), a receptor-like cytoplasmic kinase VII member, as a negative regulator of bacterial flagellin/flg22- and fungal chitin-triggered immunity. CDG1 can interact with the flg22 receptor FLAGELLIN SENSITIVE2 (FLS2) and chitin co-receptor CHITIN ELICITOR RECEPTOR KINASE1 (CERK1). CDG1 overexpression impairs flg22 and chitin responses by promoting the degradation of FLS2 and CERK1. This process requires the kinase activity of MEK KINASE1 (MEKK1), but not the Plant U-Box (PUB) ubiquitin E3 ligases PUB12 and PUB13. Interestingly, the Pseudomonas syringae effector AvrRpm1 can induce CDG1 to interact with its host target RPM1-INTERACTING PROTEIN4 (RIN4), which depends on the ADP-ribosyl transferase activity of AvrRpm1. CDG1 is capable of phosphorylating RIN4 in vitro at multiple sites including Thr166 and the AvrRpm1-induced Thr166 phosphorylation of RIN4 is diminished in cdg1 null plants. Accordingly, CDG1 knockout attenuates AvrRpm1-induced hypersensitive response and increases the growth of AvrRpm1-secreting bacteria in plants. Unexpectedly, AvrRpm1 can also induce FLS2 depletion, which is fully dependent on RIN4 and partially dependent on CDG1, but does not require the kinase activity of MEKK1. Collectively, this study reveals previously unknown functions of CDG1 in both pattern-triggered immunity and effector-triggered susceptibility in plants.
Association Between Clinical Symptoms and Radiographic Features in Late-Stage Knee Osteoarthritis Using a New Radiographic Parameter
Authors: Zhu Tengjiao , Xin Xing , Yang Bin , Liu Chen , Kou Bolong , Chen Zhongqiang , Zhang Ke 
Published: January 2021

Abstract

Objective
In this study, we proposed a new radiographic parameter, the plateau attrition index (PAI), and the PAI grades (PAIs) to explore the relationship between subchondral attrition of the tibial plateau and symptoms of knee osteoarthritis (OA) in patients with late-stage knee osteoarthritis.

Method
One hundred nineteen patients with late-stage knee osteoarthritis were enrolled. The Kellgren and Lawrence (K/L) grades and hip-knee-ankle (HKA) angle were used to characterize the radiographic features of knee OA. The bone attrition of the tibial plateau was determined by the PAI and PAIs. The symptoms of knee OA were assessed by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), which is composed of the WOMAC pain (WOMP), WOMAC stiffness (WOMS), and WOMAC function (WOMF) subscores. WOMAC pain scores were divided into non-weight-bearing pain (NWBP) and weight-bearing pain (WBP) subcategories. The Pearson correlation coefficient was used to determine the relationship between the PAI, HKA angle, and WOMAC scores. The Spearman rank correlation coefficient was used to evaluate the correlation between the WOMAC score and the PAIs and K/L grades.

Results
The distribution of the WOMAC scores according to the PAIs was significant (P &lt; .01). A positive correlation was identified between the PAI and the WOMAC, WOMP, WOMF and WBP scores (r = 0.29, 0.34, 0.26 and 0.34, P &lt; .01, respectively). In addition, the PAIs was also significantly correlated with the WOMAC, WOMP, WOMF, and WBP scores (r = 0.37, 0.38, 0.35 and 0.44, P &lt; .01, respectively).

Conclusions
The attrition of tibial subchondral bone determined by the new parameter, the plateau attrition index, was correlated with symptoms, especially weight-bearing pain in late-stage knee OA.