bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Prior Bridging Intravenous Thrombolysis With Direct Endovascular Thrombectomy for Anterior Circulation Large Vessel Occlusion: Systematic Review and Meta-Analysis
Authors: Chen Zhao-Ji , Li Xiao-Fang , Liang Cheng-Yu , Cui Lei , Yang Li-Qing , Xia Yan-Min , Cao Wei , Gao Bu-Lang 
Published: April 2021

Background: Whether bridging treatment combining intravenous thrombolysis (IVT) and endovascular thrombectomy (EVT) is superior to direct EVT alone for emergent large vessel occlusion (LVO) in the anterior circulation is unknown. A systematic review and a meta-analysis were performed to investigate and assess the effect and safety of bridging treatment vs. direct EVT in patients with LVO in the anterior circulation.Methods: PubMed, EMBASE, and the Cochrane library were searched to assess the effect and safety of bridging treatment and direct EVT in LVO. Functional independence, mortality, asymptomatic and symptomatic intracranial hemorrhage (aICH and sICH, respectively), and successful recanalization were evaluated. The risk ratio and the 95% CI were analyzed.Results: Among the eight studies included, there was no significant difference in the long-term functional independence (OR = 1.008, 95% CI = 0.845–1.204, P = 0.926), mortality (OR = 1.060, 95% CI = 0.840–1.336, P = 0.624), recanalization rate (OR = 1.015, 95% CI = 0.793–1.300, P = 0.905), and the incidence of sICH (OR = 1.320, 95% CI = 0.931–1.870, P = 0.119) between bridging therapy and direct EVT. After adjusting for confounding factors, bridging therapy showed a lower recanalization rate (effect size or ES = −0.377, 95% CI = −0.684 to −0.070, P = 0.016), but there was no significant difference in the long-term functional independence (ES = 0.057, 95% CI = −0.177 to 0.291, P = 0.634), mortality (ES = 0.693, 95% CI = −0.133 to 1.519, P = 0.100), and incidence of sICH (ES = −0.051, 95% CI = −0.687 to 0.585, P = 0.875) compared with direct EVT. Meanwhile, in the subgroup analysis of RCT, no significant difference was found in the long-term functional independence (OR = 0.927, 95% CI = 0.727–1.182, P = 0.539), recanalization rate (OR = 1.331, 95% CI = 0.948–1.867, P = 0.099), mortality (OR = 1.072, 95% CI = 0.776–1.481, P = 0.673), and sICH incidence (OR = 1.383, 95% CI = 0.806–2.374, P = 0.977) between patients receiving bridging therapy and those receiving direct DVT.Conclusion: For stroke patients with acute anterior circulation occlusion and who are eligible for intravenous thrombolysis, there is no significant difference in the clinical effect between direct EVT and bridging therapy, which needs to be verified by more randomized controlled trials.
Thrombectomy for Acute Ischemic Stroke With a New Device-Skyflow: Study Protocol for a Prospective, Multicenter, Stratified Randomized, Single-Blinded, Parallel, Positive Controlled, Non-inferiority Clinical Trial
Authors: Liu Huan , Li Zhaoshuo , Zhu Liangfu , Zhou Tengfei , Wu Qiaowei , He Yanyan , Song Xintong , He Yingkun , Li Tianxiao 
Published: April 2021

Background: Stent retriever thrombectomy is the standard treatment for acute ischemic stroke (AIS) with large vessel occlusion (LVO) in anterior circulation. The aim of the trial is to evaluate whether the new thrombectomy device-Skyflow can achieve the same safety and efficacy as Solitaire FR in the treatment.Method: This study is a prospective, multicenter, stratified randomized, single blind, paralleled, positive controlled, non-inferiority clinical trial. The safety and efficacy of vascular recanalization in AIS patients who are treated with either a new thrombectomy device-Skyflow or with Solitaire FR and within 8 h of symptom onset will be compared. A total of 192 patients will be enrolled, each group with 96 patients. The primary endpoint is successful recanalization rate after the operation. The secondary efficacy endpoints are the time from artery puncture to successful recanalization (mTICI 2b-3), NIHSS scores of 24 h (18–36 h), and 7 ± 2 days after the operation, mRS scores, and the rate of patients with mRS 0–2 scores 90 ± 14 days after the operation, and the success rate of instrument operation. The safety endpoints are the rate of symptomatic intracranial hemorrhage (sICH) and subarachnoid hemorrhage at 24 h (18–36 h) post-operation, incidence of adverse events (AE) and serious adverse events (SAE), all-cause mortality, and incidence of device defects.Discussion: This trial will provide information on the safety and efficacy of Sky-flow stent retriever in the treatment of AIS patients with anterior circulation LVO. The success of this trial will be the basis for the product to be finally officially listed and applied in China.Trial registration: Registered on 11 March 2018 with Chinese clinical trial registry. Registration number is ChiCTR1800015166.
The Comparison of Plasma and Cerebrospinal Fluid R(−)- and S(+)-Flurbiprofen Concentration After Intravenous Injection of Flurbiprofen Axetil in Human Subjects
Authors: Yao Han , Luo Xingxian , Zhang Hong , An Haiyan , Feng Wanyu , Feng Yi 
Published: April 2021

Background: Flurbiprofen axetil is a prodrug that releases the active substance through enzymatic removal of the ester moiety. It is formulated through encapsulation in a lipid microsphere carrier, and widely used to treat perioperative pain. Here, we studied the distribution of R (−)- and S (+)-flurbiprofen in human plasma and cerebrospinal fluid (CSF) after intravenous injection of flurbiprofen axetil.Methods: A total of 70 adult patients undergoing elective lower limb surgery under spinal anesthesia were given a single intravenous injection of 100-mg flurbiprofen axetil. The patients were randomly assigned to 10 groups for plasma and CSF sampling at 10 time points (5–50 min) after subarachnoid puncture and before actual spinal anesthesia. R (−)- and S (+)-flurbiprofen and CSF/plasma ratio were determined by liquid chromatography–tandem mass spectrometry.Results: R (−)-flurbiprofen concentration ranged from 2.01 to 10.9 μg/mL in plasma and 1.46–34.4 ng/mL in CSF. S (+)-flurbiprofen concentration ranged from 1.18 to 10.8 μg/mL in plasma and from 2.53 to 47 ng/mL in CSF. In comparison to S (+)-flurbiprofen, R (−)-flurbiprofen concentration was significantly higher in plasma at all time points (p &lt; 0.05) except at 30 or 40 min, and lower in CSF at all time points (p &lt; 0.05) except at 10, 15 and 40 min. Analysis after correcting drug concentration for body mass index also revealed higher plasma and lower CSF R (−)-flurbiprofen concentration. In comparison to S (+)-flurbiprofen, AUC0–50 for R (−)-flurbiprofen was larger in plasma and smaller in CSF (p &lt; 0.05 for both), and accordingly smaller CSF/plasma AUC0–50 ratio (p &lt; 0.05). There was a positive correlation between R (−)-flurbiprofen concentration and S (+)-flurbiprofen concentration in plasma (r = 0.725, p &lt; 0.001) as well as in CSF (r = 0.718, p &lt; 0.001), and a negative correlation between plasma and CSF concentration of S (+)-flurbiprofen (r = −0.250, p = 0.037), but not R (−)-flurbiprofen.Conclusion: Distribution of R (−)- and S (+)-flurbiprofen in plasma and CSF differed significantly. Penetration of R (−)-flurbiprofen into the CNS was lower than S (+)-flurbiprofen.
Association of Stress-Related Factors With Anxiety Among Chinese Pregnant Participants in an Online Crisis Intervention During COVID-19 Epidemic
Authors: Shangguan Fangfang , Wang Ruoxi , Quan Xiao , Zhou Chenhao , Zhang Chen , Qian Wei , Zhou Yongjie , Liu Zhengkui , Zhang Xiang Yang 
Published: April 2021

Background: Previous systematic review indicated the prevalence of prenatal anxiety as 14–54%. Pregnant women are a high-risk population for COVID-19. However, the prevalence of anxiety symptoms and related factors is unknown in Chinese pregnant women during COVID-19 outbreak.Objective: To investigate the prevalence of anxiety symptoms and the related factors in Chinese pregnant women who were attending crisis intervention during the COVID-19 pandemic.Methods: The data of this cross-sectional study were collected in about 2 months (February 28 to April 26, 2020). Data analysis was performed from April to May 2020. Participants completed a set of questionnaires via the Wechat Mini-program before starting the online self-help crisis intervention for COVID-19 epidemic. A total of 2,120 Chinese pregnant women who were attending a self-help crisis intervention participated in this study. A survey was developed to address possible stress-related factors in pregnant women during the COVID-19 outbreak, including demographic, socioeconomic, and pregnancy-related factors, as well as COVID-19 related factors. Generalized Anxiety Disorder-7 (GAD-7) scale and the 10-item perceived stress scale were, respectively, employed to measure anxiety and stress-related factors.Results: A total of 21.7% (459) of pregnant women reported at least mild anxiety (≥5 on the GAD-7 scale), and only 82 women reported moderate to severe anxiety (≥10 on the GAD-7 scale). Factors associated with at least mild anxiety included living in Hubei province (OR = 1.68, 95% CI = 1.32–2.13), nobody providing everyday life support (OR = 1.81, 95% CI = 1.18–2.77), pelvic pain or vaginal bleeding (OR = 1.67, 95% CI = 1.32–2.09), and higher perceived stress (OR = 6.87, 95% CI = 5.42–9.02). Having relatives or neighbors with a diagnosis of COVID-19 was not associated with anxiety (p &gt; 0.05).Conclusions and Relevance: Our findings indicate that evaluation and intervention for maternal and infant health are necessary in pregnant women with anxiety during COVID-19 epidemic, especially those with higher perceived stress, less everyday life support, or vaginal bleeding. Interactions among these related medical, social and psychological factors need to be investigated in future studies.
An Online Physical Activity Intervention for Youth With Physical Disabilities: A Pilot Study
Authors: Sharma Ritu , Latimer-Cheung Amy E. , Cairney John , Arbour-Nicitopoulos Kelly P. 
Published: April 2021

Background: Physical activity (PA) interventions are limited in number and reach for youth with physical disabilities (YPD) who experience systemic barriers that may preclude their in-person participation. Further, a lack of theory in the development and evaluation of PA interventions impedes our understanding and replication of active components of behavior change. These limitations pose challenges in the effective promotion of PA in YPD. Theory-based and more inclusive methods of PA intervention delivery must be explored in our efforts to promote PA and overall health in YPD.Methods: A pilot study was conducted to evaluate the feasibility and outcomes of an online, 4-week social cognitive theory-based PA intervention for YPD. Intervention feasibility (implementation fidelity, intervention compliance, and intervention acceptability) was evaluated through manual documentation, weekly feedback questionnaires, and open-ended feedback at 1-month post-intervention. Targeted social cognitive (outcome expectations, self-efficacy [task, self-regulatory, barrier] and self-regulation) and PA behavior outcomes were self-reported at baseline and 1-week and 1-month post-intervention.Results: Sixteen YPD (Mage = 17.4 ± 2.7 years, 69% female) completed the study. Intervention feasibility was supported by high implementation fidelity (100%), high intervention compliance (&gt;90%), and positive ratings on indicators of acceptability for all weeks of the intervention (weekly feedback questionnaire means ranging from 5.74 to 6.19 out of 7). Through open-ended feedback, participants indicated the intervention was easy to use and understand, favorably shifted their self-awareness and personal meaning of PA, and provided value and potential for future use pertaining to the learned self-regulation skills and strategies. Participants also provided formatting and content recommendations for intervention improvement. Repeated measures ANOVAs showed significant and large effect sizes for changes in participants' task (p = 0.01, n2p = 0.28) and barrier (p = 0.02, n2p = 0.24) self-efficacy, goal-setting and planning and scheduling behaviors (ps &lt; 0.001, n2ps = 0.42), and self-reported PA behavior (p = 0.02, n2p = 0.26).Conclusions: An online PA intervention for YPD is feasible and may offer potential benefit through the enhancement of self-efficacy, self-regulation, and PA behavior. Continued research is necessary to understand the efficacy and longer-term outcomes of online, theory-based interventions for YPD as a PA promotion strategy.
Circulating Survivin Protein Levels in Lung Cancer Patients Treated With Platinum-Based Chemotherapy
Authors: Puskas Rita , Bikov Andras , Horvath Peter , Lazar Zsofia , Kunos Laszlo , Nagy Reka , Pinter Gabriella , Galffy Gabriella 
Published: April 2021

The survivin protein contributes to the development and progression of tumors. Protein expression and mRNA levels correlate with clinicopathological parameters and survival of cancer patients. Our purpose was to evaluate whether circulating survivin levels have any diagnostic or predictive value in lung cancer. 118 patients with advanced stage lung cancer participated in our study. 53 suffered from adenocarcinoma (ADC), 33 from squamous cell carcinoma (SqCC), and 32 from small cell lung cancer (SCLC). We also enrolled 21 control subjects. Blood samples were collected before and after two cycles of chemotherapy. We measured survivin concentrations with ELISA. Non-parametric tests were used for analysis. We did not find significant difference in survivin levels between patients and control subjects (17.19/0–829.74/vs. 49.13/0–165.92/pg/ml; p = 0.07). We found lower survivin concentrations in patients with SqCC (0/0–171.24/pg/ml) than in those with ADC (24.94/0–626.46 pg/ml) and SCLC (45.51/0–829.74/pg/ml) (ADC vs. SqCC p &lt; 0.0001, ADC vs. SCLC p = 0.0405, SqCC vs. SCLC p &lt; 0.0001). Survivin levels were higher in stage IV patients than in patients without distant metastases (p = 0.0061), and concentrations were progressively higher with increasing number of metastatic organ sites (p = 0.04). We observed a decrease in survivin levels in ADC patients after platinum plus pemetrexed chemotherapy (26.22/0–626.46/pg/ml before vs. 0/0–114.36/pg/ml after; p = 0.01). Neither progression-free nor overall survival correlated with survivin levels at baseline. Our data imply that survivin may be involved in the development of metastases and it might be used as a biomarker of disease progression. However, circulating survivin concentrations do not predict survival of patients with lung cancer.
Meta-Analysis of Methamphetamine Modulation on Amyloid Precursor Protein through HMGB1 in Alzheimer’s Disease
Authors: Alabed Sedra , Zhou Heping , Sariyer Ilker K. , Chang Sulie L. 
Published: April 2021

The deposition of amyloid-beta (Aβ) through the cleavage of amyloid-beta precursor protein (APP) is a biomarker of Alzheimer’s disease (AD). This study used QIAGEN Ingenuity Pathway Analysis (IPA) to conduct meta-analysis on the molecular mechanisms by which methamphetamine (METH) impacts AD through modulating the expression of APP. All the molecules affected by METH and APP were collected from the QIAGEN Knowledge Base (QKB); 78 overlapping molecules were identified. Upon simulation of METH exposure using the “Molecule Activity Predictor” feature, eight molecules were found to be affected by METH and exhibited activation relationships on APP expression at a confidence of p = 0.000453 (Z-score = 3.51, two-tailed). Core Analysis of these eight molecules identified High Mobility Group Box protein 1 (HMGB1) signaling pathway among the top 5 canonical pathways with most overlap with the 8-molecule dataset. Simulated METH exposure increased APP expression through HMGB1 at a confidence of p < 0.00001 (Z-score = 7.64, two-tailed). HMGB1 is a pathogenic hallmark in AD progression. It not only increases the production of inflammatory mediators, but also mediates the disruption of the blood-brain barrier. Our analyses suggest the involvement of HMGB1 signaling pathway in METH-induced modulation of APP as a potential casual factor of AD.
Bio-Insecticide of Thymus vulgaris and Ocimum basilicum Extract from Cell Suspensions and Their Inhibitory Effect against Serine, Cysteine, and Metalloproteinases of the Red Palm Weevil (Rhynchophorus ferrugineus)
Authors: Darrag Hossam Moustafa , Alhajhoj Mohammed Refdan , Khalil Hany Ezzat 
Published: April 2021

The current study was designed to investigate the insecticide role of volatile constituents produced from cell suspensions of T. vulgaris and O. basilicum against R. ferrugineus. Constituents were extracted from cell suspension after 40 days. Growth kinetics were measured with an inoculation of Verticillium dahliae and identified by GC-MS. Total volatile phenolic constituents were measured. Insecticidal activity against R. ferrugineus (adult) and proteolytic enzyme activity in larvae were assessed. GC-MS showed that the T. vulgaris extract has higher amounts of thymol, p-cymene, γ-terpinene, β-caryophyllene, and linalool in comparison to the O. basilicum extract, which is rich in estragole, β-terpineol, (E)-β-ocimene, 1,8-cineole, germacrene D, and eugenol. The T. vulgaris extract showed an LC50 of 1032 µg/mL, followed by O. basilicum with an LC50 of 1246 µg/mL. The IC50 values against the total proteases were 110.8 and 119.4 µg/mL for T. vulgaris and O. basilicum, respectively. The IC50 for the trypsin-like serine proteinase assessment was 81.6 and 91 µg/mL for T. vulgaris and O. basilicum, respectively. Cysteine, chymotrypsin, and metalloproteinase assessment showed an IC50 above 5000 µg/mL for both extracts. The study is proposed as a potential approach to use T. vulgaris and O. basilicum extract as a bio-insecticide against R. ferrugineus using an accessible and efficient cell suspension technique.
Knowledge, Attitudes, Practices and Some Characteristic Features of People Recovered from COVID-19 in Turkey
Authors: Yakut Seda , Karagülle Burcu , Atçalı Tuğçe , Öztürk Yasin , Açık Mehmet Nuri , Çetinkaya Burhan 
Published: April 2021

Background and objectives: The whole world is spending an extraordinary effort by implementing various measures to control and prevent the COVID-19 pandemic. The effectiveness of the preventive measures is greatly influenced by the public’s knowledge, attitudes, and practices (KAP) towards the disease. In this study, KAP values and some characteristic features of people recovered from COVID-19 were determined by conducting a questionnaire survey. Materials and Methods: The questionnaire survey was conducted between 1 and 10 January 2021 on people who recovered from COVID-19 in a total of 150 different locations in Turkey. The questionnaire consisted of 46 questions: 14 for determining demographic and some characteristic features of the participants, and 32 for determining their knowledge, attitudes, and practices. The data obtained were evaluated using descriptive statistics, chi-squared tests, t-tests, and one-way analysis of variance (ANOVA). Results: It was determined that 63% of the participants had at least one chronic illness, 3.9% suffered from the disease twice, and 45.2% changed their smoking habits. The average knowledge score of the participants about COVID-19 was calculated as 10.25 (SD = 2.37; range 0–15). The participants were found to have a high level of knowledge about the symptoms and prevention methods in general, and positive changes in post-illness attitudes and behaviors. However, there was a great instability regarding the drugs and vaccines used in the treatment of COVID-19. Conclusions: This was the first study carried out in Turkey to determine knowledge, attitudes, practices, and some characteristic features of people who recovered from COVID-19. It was suggested that health authorities in the country need to develop more effective strategies and policies to find out permanent solutions in order to control and prevent the COVID-19 pandemic by taking into account the concerns of the public, particularly with regards to the drugs used in the treatment and vaccination.
PENGARUH STRATEGI PEMASARAN TERHADAP LOYALITAS PELANGGAN MELALUI KEPUASAN PELANGGAN SEBAGAI VARIABEL INTERVENING
Authors: Panjaitan Dertaida , Setyorini Retno 
Published: April 2021

ABSTRAK
Penelitian ini dilakukan untuk mengetahui pengaruh strategi pemasaran terhadap loyalitas pelanggan melalui kepuasan pelanggan pada digital payment OVO di Kota Bandung. Dengan adanya fenomena yang terjadi pada strategi pemasaran yang dilakukan oleh digital payment OVO yang mempengaruhi kepuasan dan loyalitas pengguna OVO di Kota Bandung. Diantaranya yaitu keluhan terhadap aplikasi OVO yang error, penanganan masalah yang tidak direspon dengan cepat oleh pihak yang terkait, points yang tidak bisa digunakan oleh pengguna dan masalah-masalah lainnya yang mempengaruhi pengguna OVO. Metode penelitian yang digunakan yaitu metode kuantitatif dengan jenis penelitian adalah deskriptif kausal, skala pengukuran yang digunakan adalah skala likert. Metode analisis data yang digunakan pada penelitian ini adalah Structural Equation Modeling (SEM). Pengolahan data dilakukan dengan menggunakan SmartPLS. Hasil dari penelitian menunjukkan bahwa variabel strategi pemasaran mempengaruhi variabel loyalitas pelanggan melalui kepuasan pelanggan sebagai variabel intervening pada digital payment OVO di Kota Bandung. Hal ini disebabkan karena kedua variabel struktural yang berpengaruh secara positif dan signifikan terhadap variabel loyalitas pelanggan dengan nilai to sebesar 4,880> nilai tα 1,661.

Kata kunci: Strategi pemasaran, kepuasan pelanggan, loyalitas pelanggan.
ANALISIS KAPABILITAS DINAMIS IVORY RADIO DALAM MENGHADAPI ERA KONVERGENSI DIGITAL
Authors: Asrunputri Aisyah Pia , Zulkarnaen Mutiara 
Published: April 2021

Seiring berkembangnya teknologi didalam industri, menciptakan peluang dan ancaman bagi organisasi-organisasi didalamnya. Diperlukan kapabilitas dinamis dalam merespon perubahan-perubahan tersebut bagi organisasi untuk dapat bertahan didalam industri. Kapabilitas dinamis adalah kemampuan organisasi dalam mengintegrasikan, membangun, dan merekonfigurasi kompetensi internal dan eksternal untuk merespon perubahan yang terus menerus yang mana menjadi kesempatan yang baik bagi organisasi untuk terus tumbuh dan berkembang. Dengan adanya kapabilitas dinamis, hal ini dapat membantu organisasi dalam meraih posisi kompetitif baik untuk jangka pendek dan jangka panjang. Namun demikian, untuk membangun kapabilitas dinamis organisasi harus dapat memiliki kapasitas untuk membentuk dan merasakan peluang dan ancaman, memanfaatkan peluang yang ada serta merekonfigurasi sumber daya organisasi baik sumber daya yang terlihat dan tidak terlihat. Salah satu organisasi yang berhasil membuat infrastruktur serta mekanisme dalam menghadapi era konvergensi digital adalah Ivory Radio. Kesiapan dari Ivory Radio tersebut bersumber dari kapabilitas dinamis yang mumpuni dan berkelanjutan sehingga membuat Ivory Radio dapat mempertahankan posisi kompetitifnya didalam industri.
Kata Kunci: Kapabilitas Dinamis, Ivory Radio, Era Konvergensi Digital