bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neighborhood Characteristics and Accelerated Aging: Evidence From the Health and Retirement Study
Authors: Lee Haena , Ailshire Jennifer , Crimmins Eileen 
Published: December 2021

Abstract
An individual’s rate of aging directly impacts one’s functioning, morbidity and mortality. Identifying factors related to accelerated or delayed aging may provide important information for potential areas of intervention. While race/ethnicity, socioeconomic status and behavior characteristics have been linked to biological aging, it is unclear whether neighborhood characteristics are associated with one’s rate of aging. We use a novel aging measure, Expanded Biological Age, from the 2016 Health and Retirement Study Venous Blood Study (HRS-VBS) to investigate whether individuals living with unfavorable neighborhood conditions are experiencing accelerated aging compared to those living in more favorable conditions. We constructed a summary measure of expanded biological age using 22 novel biomarkers in the HRS-VBS; we then regressed the summary measure on age and used the residuals as indicators of accelerated or delayed aging. We measured neighborhood physical disorder, presence of green space, and perceived social cohesion using the 2016 HRS Interviewer Observation data and Self-Administered Questionnaire. We find that individuals living with higher levels of neighborhood physical disorder appeared 1.05 years older biologically than the average for those of the same chronological age. Individuals living near green space including parks were 1.5 years younger biologically than expected based on their chronological age though this association was marginally significant. We did not find an association between neighborhood social cohesion and accelerated aging. This implies that living with severe neighborhood disorder, characterized by presence of disrepair, trash/litter, and abandoned structures, and living near green space, play an important role in who lives longer.
Identifying Senescent Cells That Drive Aging
Authors: Niedernhofer Laura 
Published: December 2021

Abstract
Cellular senescence is a potent tumor suppressor mechanism. However, the untoward effect is that the accumulation of senescent cells promotes loss of resilience, aging and age-related diseases. One approach to maintaining the benefits of senescence while preventing the negative consequences is senolytic therapies: drugs that do not prevent senescence, but selectively kill senescent cells. Since virtually any type of cell can become senescent, it is important to identify the lineages of senescent cells that are most potent at driving loss of tissue homeostasis and aging. This will enable honing development of senolytics. We used a genetic approach to drive increased genotoxic stress, a potent inducer of senescence, in a tissue specific manner. The impact of this targeted senescence on different organs and cell types will be discussed, identifying a lead target for senolytics.
Minimizing Complications of Aging That Lead to Dry Mouth and Poor Oral Health
Authors: Papas Athena 
Published: December 2021

Abstract
Poor oral health causes severe pain and untreated infections to spread throughout the body. For older adults, the prevalence of root decay exceeds that of any other medical condition. Our research shows tooth loss and edentulousness were associated with increased mortality and inversely associated with BMI, waist circumference, blood pressure, and fasting blood glucose. Our Stop-it study found people who lost bone density had fewer teeth, problems chewing, and involuntary weight loss and frailty. 88% of the elderly take medications that cause loss of saliva. Sjögren’s and radiation therapy for head and neck cancer patients heighten risk. Without saliva, patients have increased tooth decay, periodontal disease and fungal infections, salivary gland blockage, and problems swallowing and speaking. Dry mouth leads people to suck on candy that further increase caries. Substituting sugarfree gum for candy increases salivary flow and reduces dental caries. Brushing, flossing, and limiting sugar also lessen tooth decay.
Research Confirms Effectiveness of Oral Health Preventive Practices
Authors: Dodds Michael 
Published: December 2021

Abstract
Lack of insurance or funds for dental services, lack of access to dental offices, fear of dentists, and avoidance of dental offices during COVID can lead to oral health problems in older adults. Brushing, flossing, and drinking fluoridated water can protect teeth when dentists are unavailable. Limiting intake frequency of carbohydrates and chewing sugarfree gum after eating add protection. A recent systematic review and meta-analysis confirmed the effectiveness of sugarfree gum in reducing caries, in children and adults who chewed sugarfree gum compared with those who did not chew. Chewing sugarfree gum significantly reduced caries increment, with a prevented fraction of 28 percent, roughly equivalent to the prevented fractions for fluoride toothpastes and supplements. A follow-up systematic review provides further evidence that chewing sugarfree gum reduces the numbers of Streptococcus mutans in the oral cavity. Finally, chewing sugarfree gum could alleviate symptoms of xerostomia and may reduce caries.
The Difference LTC Corporate Ownership Makes in Collaborations With Emergency Operation Centers During Disasters
Authors: Dobbs Debra , June Joseph , Dosa David , Peterson Lindsay , Hyer Kathryn 
Published: December 2021

Abstract
Collaboration between nursing homes (NHs) and assisted living communities (ALCs) with state and local entities (e.g., emergency operation centers (EOCs)) is critical during a disaster. The corporate structure of NHs and ALCs can make a difference in their ability to collaborate with these entities during a disaster. This mixed-method study examines differences in satisfaction with collaboration with state and local entities during Hurricane Irma in Florida in 2017 between corporate-owned NHs (N=24), larger (25+ beds) ALCs (N=38) and smaller ALCs (N=30). We also explore collaboration in Florida NHs (N=35) and ALCs (N=123) specific to COVID19. Scaled 1-5 survey data results indicate that small ALCs are the least satisfied (M=2.90) with EOC collaboration, compared to NHs (M=3.04) and larger ALCs (M=3.33) during Irma. Smaller ALCs were more dissatisfied with COVID19 mandates compared to larger ALCs and NHs. Ways to improve collaboration during a disaster, especially for smaller ALCs, will be discussed.
Positive Aspects of Caregiving in Incident and Long-Term Caregivers: Role of Social Engagement and Distress
Authors: Liu Chelsea , Marino Victoria , Howard Virginia , Haley William , Roth David 
Published: December 2021

Abstract
Positive aspects of caregiving (PAC) are positive appraisals that caregivers report about their role such as feeling appreciated or important, and may increase with caregiver adaptation over time. We aimed to examine differences in PAC by caregiving duration and social engagement, controlling for measures of distress. A total of 283 African American or White caregivers from the Caregiving Transitions Study with a wide range of caregiving durations were included in our analysis. We used multivariable linear regressions to model total PAC score on years of caregiving and social engagement (social network, monthly social contact), adjusting for age, sex, race, marital status, relationship to care recipient, dementia status of care recipient and measures of distress (depressive symptoms, perceived stress, caregiving strain). Caregivers with higher social engagement reported significantly higher PAC while caregivers with longer duration of care reported marginally higher PAC in most analytic models. African American caregivers reported higher PAC compared to White caregivers. Dementia caregivers reported lower PAC than non-dementia caregivers in models that adjusted for demographic variables and social network size, but the association was attenuated with the addition of caregiving strain. In summary, higher social engagement and longer care duration were associated with higher PAC after adjusting for demographic variables and measures of distress. Future studies should aim to understand how caregivers shift appraisal to positive aspects of their role and explore implementation of interventions targeting PAC in order to improve the caregiving experience.
The impact of the Caring Callers Program on Senior Companion Volunteers and Clients During the COVID-19 Pandemic
Authors: Lee Kathy , Fields Noelle , Feinhals Gretchen , Calhoun Melanie 
Published: December 2021

Abstract
Purpose of the Study: The purpose of this study was to examine the impact of the Caring Callers Program on older adults and volunteers. Our research team piloted this telephone reassurance program during the COVID-19 pandemic. In the Caring Callers Program, socially isolated older adults were paired with older adult volunteers from the Senior Companion Program (20 pairs). Methods: In the Caring Callers Program, Senior Companion volunteers provided the clients with emotional support through a weekly phone call over the 12 weeks period (May through July 2020). Prior to the intervention implementation, the volunteers received a two-hour group-based training through a teleconference platform. Program outcomes were measured through quantitative and qualitative approaches. Results: The clients (mean age=73.5) showed significantly increased overall self-rated health at post-test, compared to pre-test and they discussed social and emotional benefits. The clients were very satisfied with the program and indicated that the program met their expectations. Our individual, in-depth interviews with the volunteers (mean age=73.2) also revealed that the volunteers were able to develop their skills that are helpful for their Senior Companion volunteer activities and experience mutual benefits by spending their time more purposefully. Overall, our participants shared that they wanted to continue participating in the Caring Callers Program. Discussion: We learned the importance of training not only for the volunteers but also for the clients, prior information on their pair, making sure of the volunteer-client fit, and benefits of using telephone particularly in this group of vulnerable older adults.
The Role of Intersectionality in Access to Technology Among Older Adults
Authors: Suntai Zainab , Beltran Susanny 
Published: December 2021

Abstract
In the era of COVID-19, technology has become a primary means of connecting with the world while maintaining physical distance, which is crucial for older adults who are at disproportionately high risk of infection and death. Throughout the pandemic, there has been increased emphasis on using telehealth to access medical and mental health care, and technology (e.g., apps, social media, video calls) for social interactions/communication to mitigate loneliness/isolation. Thus, COVID-19 has increased the need for older adults to access technology, and widened disparities experienced by those with limited access. This study used data from the 2018 National Health and Aging Trends Study, an annual longitudinal panel survey of Medicare beneficiaries aged 65+ in the U.S, to explore the association between the interaction of race/ethnicity and sex, and access to both a working cell phone and laptop/computer. Chi-square tests and multivariable logistic regressions were conducted. The sample (N=2,442) was 83.7% white, 8.5% Black, and 7.8% Hispanic. After accounting for other explanatory variables, logistic regression analysis indicated significantly higher odds of not having both a working cell phone or computer/laptop among White women (OR=1.518, CI=.1.510-1.527), Black men (OR=.1.741, CI= 1.720-1.763), Black women (OR=2.567, CI= 2.545-2.589), Hispanic men (OR=1.036, CI=1.022-1.050), and Hispanic women (OR=2.265, CI=.2.243-2.287) compared to White men. Overall, Hispanic and Black women were the least likely to have access to technology compared to other groups. Addressing technological equity remains a need. Future research should consider how the provision of devices along with technological literary programs can improve well-being among BIPOC women.
Sporadic hypothalamic hamartoma is a ciliopathy with somatic and bi-allelic contributions
Authors: Green Timothy E , Motelow Joshua E , Bennett Mark F , Ye Zimeng , Bennett Caitlin A , Griffin Nicole G , Damiano John A , Leventer Richard J , Freeman Jeremy L , Harvey A Simon , Lockhart Paul J , Sadleir Lynette G , Boys Amber , Scheffer Ingrid E , Major Heather , Darbro Benjamin W , Bahlo Melanie , Goldstein David B , Kerrigan John F , Heinzen Erin L , Berkovic Samuel F , Hildebrand Michael S 
Published: December 2021

Abstract
Hypothalamic hamartoma with gelastic seizures is a well-established cause of drug-resistant epilepsy in early life. The development of novel surgical techniques has permitted the genomic interrogation of hypothalamic hamartoma tissue. This has revealed causative mosaic variants within GLI3, OFD1 and other key regulators of the sonic-hedgehog pathway in a minority of cases. Sonic-hedgehog signalling proteins localize to the cellular organelle primary cilia. We therefore explored the hypothesis that cilia gene variants may underlie hitherto unsolved cases of sporadic hypothalamic hamartoma. We performed high-depth exome sequencing and chromosomal microarray on surgically resected hypothalamic hamartoma tissue and paired leukocyte-derived DNA from 27 patients. We searched for both germline and somatic variants under both dominant and bi-allelic genetic models. In hamartoma-derived DNA of seven patients we identified bi-allelic (one germline, one somatic) variants within one of four cilia genes—DYNC2I1, DYNC2H1, IFT140 or SMO. In eight patients, we identified single somatic variants in the previously established hypothalamic hamartoma disease genes GLI3 or OFD1. Overall, we established a plausible molecular cause for 15/27 (56%) patients. Here, we expand the genetic architecture beyond single variants within dominant disease genes that cause sporadic hypothalamic hamartoma to bi-allelic (one germline/one somatic) variants, implicate three novel cilia genes and reconceptualize the disorder as a ciliopathy.
Prevention of surgical adhesions with gelatine sealing sheet in a canine adhesion model
Authors: Niwa Kosuke , Yamashita Keigo , Hirose Tomoaki , Hiraga Shun , Fukuba Ryohei , Takemura Junichi , Nishikawa Hiroshi , Taniguchi Shigeki 
Published: December 2021

AbstractOBJECTIVESAlthough reoperation has been increasingly performed in cardiovascular surgery in recent years, preventing surgical adhesions remains an unsolved complication. Therefore, this study aimed to investigate whether gelatine sealing sheets are more effective than fibrin sealing sheets in preventing surgical adhesions.METHODSBilateral femoral arteries of 20 beagle dogs under general anaesthesia were pricked with syringe needles, and gelatine and fibrin sealing sheets were applied on the bleeding points to make canine adhesion models. The femoral artery was harvested after 4 and 12 weeks to evaluate adhesion formations. The adhesive grade was quantified by scoring the area and strength of adhesion tissues. Histological staining was performed to examine the structural features of surgical adhesions.RESULTSSignificantly fewer macroscopic adhesions were observed with gelatine sealing sheets than those with fibrin sealing sheets at 4 and 12 weeks postoperatively. Microscopically, CD3+ T lymphocytes at 4 and 12 weeks postoperatively in gelatine sealing sheets were significantly lower than those in fibrin sealing sheets. Microvessel density determined by CD34 at 4 and 12 weeks postoperatively in gelatine sealing sheets was also significantly lower than those in fibrin sealing sheets.CONCLUSIONSThe gelatine sealing sheets are more effective than the fibrin sealing sheets in preventing surgical adhesions. These findings suggest that the gelatine sealing sheet may help prevent adhesions and thus be a therapeutically effective biomaterial in vascular surgery.
Determinants of the use of insecticide-treated mosquito nets in pregnant women: a mixed-methods study in Ghana
Authors: Dun-Dery F , Kuunibe N , Meissner P , Winkler V , Jahn A , Müller O 
Published: December 2021

Abstract

Background
Malaria in pregnancy remains a significant cause of morbidity and mortality, affecting the highly endemic countries of sub-Saharan Africa (SSA). Insecticide-treated nets (ITNs) are effective for malaria prevention. However, poor adherence in SSA remains a challenge.

Methods
We conducted a standard questionnaire survey among 710 pregnant women from 37 primary care clinics in the Upper West Region of Ghana from January through May 2019. Using a sequential explanatory design, we integrated the survey data from six focus group discussions with pregnant women.

Results
While 67% of women had some general knowledge about malaria prevention, only 19% knew the specific risks in pregnancy. Determinants of ITN use included ITN ownership (odds ratio [OR] 2.4 [95% confidence interval {CI} 1.3 to 4.4]), good maternal knowledge of the risks of malaria in pregnancy (OR 2.4 [95% CI 1.3 to 4.3]) and more antenatal care (ANC) contacts (OR 1.3 [95% CI 1.0 to 1.5)]. Focus group discussions showed that non-use of ITNs resulted from inappropriate hanging infrastructure, a preference for other malaria prevention alternatives, allergy and heat.

Conclusions
Specific maternal knowledge of malaria risks in pregnancy was low and influenced the regular use of ITNs. Community and ANC-based malaria interventions should prioritize increasing knowledge of the specific risks of malaria.
Development of Chromium(III) Selective Potentiometric Sensors for Its Determination in Petroleum Water Samples Using Synthesized Nano Schiff Base Complex as an Ionophore
Authors: Ali Tamer Awad , Mohamed Gehad G 
Published: December 2021

AbstractBackgroundMany analytical techniques, such as X-ray fluorescence spectrometry, inductively coupled plasma-atomic emission spectrometry, and even traditional spectroscopic and fluorimetric methods, are used for the measurement of Cr(III) ions. These methods are sophisticated and very expensive, so the cheapest and low-cost ion selective electrodes were used.ObjectiveThe quantification of Cr(III) ions in various samples of petroleum water using ion selective electrodes was suggested. Nano chromium modified carbon paste sensor (MCPE) and nano chromium modified screen printed sensor (MSPE) based on Schiff base Cr(III) complex are developed.MethodThe developed nano Cr(III) Schiff base chelate was characterized using elemental, spectroscopic, and thermal analysis techniques. The proposed nano Cr(III) has good properties for antibacterial and antifungal activity. The modified carbon paste and screen-printed sensors were fabricated for determination of Cr(III) ion.ResultsThe proposed MCPE (sensor I) and MSPE (sensor II) obeys Nernstian equation upon incorporating nano Cr(III) ionophore in the paste at 25°C with a trivalent cationic slope of 18.8 ± 0.2 and 20.0 ± 0.4 mV/decade. They have showed fast response time around 8 and 5 s, and they may be used for at least 98 and 240 days without significant changes in MCPE and MSPE potential, respectively. The sensors I and II showed good selectivity for Cr(III) ion toward a wide variety of metal ions or anions as confirmed by potentiometric selectivity coefficients values. The detection and quantification limits were defined alongside the other process validation parameters. The results have been compared well to those obtained by atomic absorption spectrometry (AAS), and the data of F- and t-test indicated no significant difference between the proposed and AAS methods.ConclusionsThese sensors have been used to determine Cr(III) ions in genuine spiked different petroleum well water samples with satisfactory percentage recoveries, low standard, and relative standard deviation values using direct potentiometric and standard addition methods. The proposed method of producing nano Cr(III) complex as a sensor material possesses the distinct advantages of being simple, easily reproducible, appropriate for operation, and highly selective and sensitive.HighlightsModified carbon paste and screen-printed electrodes were fabricated based on nano Cr(III) complex as ionophore. The electrodes follow Nernstian behavior, and they optimized according to IUPAC recommendation. They showed a high selectivity for Cr(III) ion over many bi- or trivalent metal ions and anions. The results obtained compared well with those obtained using AAS. They successfully applied for determination of Cr(III) in petroleum water samples.
Comparative Study of the Selectivity Power of Colorimetric Method Over Chromatographic Methods for the Analysis of Valaciclovir Hydrochloride
Authors: Morgan Eman M , Lotfy Hayam Mahmoud , Fayez Yasmin Mohammed , Abdelkawy Mohamed 
Published: December 2021

Abstract

Background
Valaciclovir hydrochloride (VAL) is an essential antiviral prodrug used to cure various types of herpes. Analysis of VAL by different analytical techniques demonstrates a persuasive aspect that is favorable in quality control application.

Objective
This study describes a comparison between colorimetric and chromatographic (RP-high performance liquid chromatography (HPLC) and thin-layer chromatography (TLC)-densitometric) methods concerning selectivity and specificity for the determination of VAL in all possible degradation products (alkali- and acid-induced degradation products, namely aciclovir [ACI] and guanine [GUA], respectively) in their synthetic mixture and pharmaceutical formulations.

Method
The colorimetric method was accomplished by forming a highly colored complex with ferric hydroxamate reagent measured at 493 nm in the concentration range (0.20–1.60 mg/mL). Both chromatographic methods were successfully applied using ultraviolet (UV) detection at 256 nm in the concentration range (2.00–5.00 µg/mL) for the RP-HPLC method and (10.00–900.00 ng/band) for the TLC-densitometric method.

Results
The linearity studies, regression equations, assay parameters, and validation sheet of the proposed colorimetric and chromatographic methods to determine VAL were obtained with highly acceptable values.

Conclusions
The International Council for Harmonization (ICH) guidelines were followed to validate the described methods and the statistical comparison regarding both accuracy and precision, and satisfactory results were accomplished.

Highlights
In this study, we configure a full comparative study between different analytical methods for the analysis of challengeable mixture containing the drug of interest, VAL, along with its degradation products, ACI and GUA.