bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cladocera paleocommunity to disentangle the impact of anthropogenic and climatic stressors on a deep subalpine lake ecosystem (Lake Iseo, Italy)
Authors: Leoni Barbara , Patelli Martina , Nava Veronica , Tolotti Monica 
Published: March 2021

AbstractIn big lakes with strong anthropogenic pressure, it is usually difficult to disentangle the impacts of climate variability from those driven by eutrophication. The present work aimed at the reconstruction of change in the species distribution and density of subfossil Cladocera in Lake Iseo (Italy) in relation to climate and anthropogenic pressure. We related subfossil Cladocera species composition and density in an 80-cm sediment core collected in the pelagic zone of Lake Iseo to long-term temperature trends and phosphorus concentration inferred by diatoms frustules. The Cladocera remains detected in Lake Iseo sediment reflected the species composition and density of modern pelagic Cladocera assemblages. Cladocera rapidly respond to environmental change, and that climate change combined with eutrophication can induce changes in community composition and species density. At the beginning of twentieth century, when global warming was not yet so accentuated, the nutrient increase in water resulted as the principal driver in determining the long-term development of plankton communities and pelagic food web structure. Moreover, catchment-related processes may decisively affect both species composition and density of the lake planktonic communities due to the decrease of lake water transparency induced by input of inorganic material from the catchment area to the lake. The paleolimnological investigation, through the combined study of biotic and abiotic factor, allowed clarifying the synergic effects of the most important drivers of change in lake ecosystems, suggesting that climatic factors should be considered with nutrient availability as determinant element in controlling the temporal development of plankton communities and pelagic food web structure.
Early Genital Surgery in Disorders/Differences of Sex Development: Patients’ Perspectives
Authors: Bennecke Elena , Bernstein Stephanie , Lee Peter , van de Grift Tim C. , Nordenskjöld Agneta , Rapp Marion , Simmonds Margaret , Streuli Jürg C. , Thyen Ute , Wiesemann Claudia ,   the dsd-LIFE Group
Published: March 2021

AbstractControversy continues over a proposed moratorium on elective genital surgery in childhood for disorders/differences of sex development (DSD). Empirical evidence on patient preference is needed to inform decision-making. We conducted a multicentre survey by cross-sectional questionnaire in 14 specialized clinics in six European countries. The sample comprised 459 individuals (≥ 16 years) with a DSD diagnosis, including individuals with congenital adrenal hyperplasia (CAH) (n = 192), XY DSD with prenatal androgen effect (A) (n = 150), and without (nA) (n = 117). Main outcome measures were level of agreement with given statements regarding genital surgery, including clitoris reduction, vaginoplasty, and hypospadias repair. A total of 66% of individuals with CAH and 60% of those with XY DSD-A thought that infancy or childhood were the appropriate age for genital surgery. Females with XY DSD were divided on this issue and tended to prefer vaginoplasty at a later age (XY DSD-A 39%, XY DSD-nA 32%). A total of 47% of males preferred early hypospadias surgery. Only 12% (CAH), 11% (XY DSD-A), and 21% (XY DSD-nA) thought they would have been better off without any surgery in childhood or adolescence. Individuals who had early genital surgery were more likely to approve of it. Outcome data failed to support a general moratorium on early elective genital surgery. Participant perspectives varied considerably by diagnostic category, gender, history of surgery, and contact with support groups. Case-by-case decision-making is better suited to grasping the ethical complexity of the issues at stake.Trial registration: German Clinical Trials Register DRKS00006072.
Inhibition of growth rate and cylindrospermopsin synthesis by Raphidiopsis raciborskii upon exposure to macrophyte Lemna trisulca (L)
Authors: Duchnik Kornelia , Bialczyk Jan , Chrapusta-Srebrny Ewelina , Bober Beata 
Published: March 2021

AbstractImpact of macrophyte Lemna trisulca on the growth rate and synthesis of cylindrospermopsin (CYN) by cyanobacterium Raphidiopsis raciborskii was determined. The presence of L. trisulca inhibited the biomass accumulation of the cyanobacterium by 25% compared to the control during co-cultivation. The simultaneous cultivation of these organisms slightly affected the inhibition of macrophyte growth rate by 5.5% compared to the control. However, no morphological changes of L. trisulca after incubation with cyanobacteria were observed. It was also shown that the long-term (35 days) co-cultivation of R. raciborskii and L. trisulca led to a decrease in CYN concentration in media and cyanobacterial cells by 32 and 38%, respectively, compared to the values obtained for independent cultivation of cyanobacterium. Excessive absorption of phosphate ions by L. trisulca from the medium compared to nitrate ions led to a significant increase in the nitrate:phosphate ratio in the media, which inhibits the development of cyanobacterium. The obtained results indicate that L. trisulca in the natural environment may affect the physiology of cyanobacteria. The presented study is the first assessment of the allelopathic interaction of macrophyte and R. raciborskii.
Genetic liability to insomnia in relation to cardiovascular diseases: a Mendelian randomisation study
Authors: Yuan Shuai , Mason Amy M. , Burgess Stephen , Larsson Susanna C. 
Published: March 2021

AbstractThe present study aimed to determine the associations between insomnia and cardiovascular diseases (CVDs) using Mendelian randomisation (MR) analysis. As instrumental variables, we used 208 independent single-nucleotide polymorphisms associated with insomnia at the genome-wide significance threshold in a meta-analysis of genome-wide association studies in the UK Biobank and 23andMe including a total of 397 959 self-reported insomnia cases and 933 057 non-cases. Summary-level data for nine CVDs were obtained from the UK Biobank including 367 586 individuals of European ancestry. After correction for multiple testing, genetic liability to insomnia was associated with higher odds of six CVDs, including peripheral arterial disease (odd ratio (OR) 1.22; 95% confidence interval (CI), 1.21, 1.33), heart failure (OR 1.21; 95% CI, 1.13, 1.30), coronary artery disease (OR 1.19; 95% CI, 1.14, 1.25), ischaemic stroke (OR 1.15; 95% CI, 1.06, 1.25), venous thromboembolism (OR 1.13; 95% CI, 1.07, 1.19) and atrial fibrillation (OR 1.10; 95% CI, 1.05, 1.15). There were suggestive associations for aortic valve stenosis (OR, 1.17; 95% CI, 1.04, 1.32) and haemorrhagic stroke (OR 1.14; 95% CI, 1.00, 1.29) but no association for abdominal aortic aneurysm (OR, 1.14, 95% CI, 0.98, 1.33). The patterns of associations remained with mild attenuation in multivariable MR analyses adjusting for genetically correlated phenotypes and potential mediators, including sleep duration, depression, body mass index, type 2 diabetes and smoking. The present MR study suggests potential causal associations of genetic liability to insomnia with increased risk of a broad range of CVDs.
Pathways to Digital Service Innovation: The Role of Digital Transformation Strategies in Established Organizations
Authors: Soto Setzke David , Riasanow Tobias , Böhm Markus , Krcmar Helmut 
Published: March 2021

AbstractDigital technologies are radically changing how established organizations design novel services. Digital transformation (DT) strategies are executed to manage the transition from product-centric to service-centric business models based on digital technologies. However, little is known about what configurations of DT strategies lead to successful digital service innovation (DSI) in established organizations. We employ fuzzy-set Qualitative Comparative Analysis on a set of 17 case studies of DT strategies from established organizations with different industry backgrounds. We identify several distinct configurations of DT strategies that lead to successful and unsuccessful DSI. Based on these configurations, we deduce that the threat of digital disruption negatively impacts an organization’s innovation activities. Furthermore, we find that strategic partnerships can be leveraged by organizations that face an imminent threat of digital disruption while organizations with competitive advantages may rely on “do-it-yourself” approaches. Lastly, we find that the involvement of a C-level executive is a necessary requirement for successful DSI. Our results contribute to theory by integrating research on DSI and DT, providing a perspective on DSI failure, and employing a configurational research approach that allows us to highlight interdependencies between factors as well as insights into the individual factors. Furthermore, we provide actionable recommendations for executives.
The Interplay of Parental Response to Anger, Adolescent Anger Regulation, and Externalizing and Internalizing Problems: A Longitudinal Study
Authors: Otterpohl Nantje , Wild Elke , Havighurst Sophie S. , Stiensmeier-Pelster Joachim , Kehoe Christiane E. 
Published: March 2021

AbstractNumerous studies have reported substantive correlations between anger socialization, children’s anger regulation, and internalizing/externalizing problems. However, substantially less is known about the interplay among these constructs during the developmental stage of adolescence, and longitudinal studies on causal relations (i.e., parent-directed, adolescent-directed, or reciprocal effects) are rare. It is also unclear whether the development of internalizing and externalizing problems have similar causal relations. We collected three waves of longitudinal data (Grade 6, Grade 7, Grade 9) from multiple informants. A sample of N = 634 adolescents (mostly 11–12 years at Time 1; 50.6% male) and their parents (predominantly Caucasian with German nationality) completed questionnaires assessing parents’ responses to anger, adolescents’ anger regulation, and adolescents’ internalizing/externalizing problems at each wave. Comparisons of different cross-lagged models revealed reciprocal rather than unidirectional effects. However, we found more parent-directed effects with respect to the development of internalizing problems, whereas relations regarding externalizing problems were more adolescent-directed, i.e., adolescents’ externalizing problems and their anger regulation predicted changes in their parents’ responses to anger across time. Adolescent anger regulation was an important maintaining factor of parents’ responses to anger in later adolescence. Our findings suggest that assumptions regarding bidirectional relations should be emphasized much more in emotion socialization frameworks, particularly for the period of adolescence. Moreover, our study emphasizes the transdiagnostic importance of parents’ responses to anger for both externalizing and internalizing problems and also suggests different underlying mechanisms.
Parent Relationship Satisfaction and Reflective Functioning as Predictors of Emotional Availability and Infant Behavior
Authors: Salo Saara J. , Pajulo Marjukka , Vinzce Lazlo , Raittila Simo , Sourander Johanna , Kalland Mirjam 
Published: March 2021

AbstractMarital and parenting systems are likely to interact during the first year of an infant’s life. This study examines the longitudinal interrelations of relationship satisfaction and parental reflective functioning (PRF) and their predictive relations with later emotional availability (EA) and infant social-emotional behaviors (SEB) including skills as well as behavioral problems among first-time Finnish mothers and fathers (n = 556). The follow-up period was between three and 12 months. In addition to having direct effects, we examined a mediational model in which self-reports on PRF factors of interest and curiosity and appropriateness of reasoning would mediate the effects of previous relationship satisfaction to the parent and dyadic side of EA and infant SEB at 12 months. The results show significant stability for relationship satisfaction and PRF for both mothers and fathers as well as direct effects on EA and SEB. However, we found differences between mothers and fathers. For mothers, path analysis indicated support for a mediational model where earlier relationship satisfaction predicted later EA and infant problem behaviors also through the current level of PRF. For fathers, both relationship satisfaction and PRF had direct, but not mediated, effects, and on both infant problem behaviors as well as infant social competence. Together, despite these differences, focusing clinically on both relationship satisfaction and PRF may prove significant in preventing later relational and/or infant difficulties in SEB for both mothers and fathers.
Interface Roughening in Two Dimensions
Authors: Münster Gernot , Cañizares Guerrero Manuel 
Published: March 2021

AbstractRoughening of interfaces implies the divergence of the interface width w with the system size L. For two-dimensional systems the divergence of $$w^2$$

w
2

is linear in L. In the framework of a detailed capillary wave approximation and of statistical field theory we derive an expression for the asymptotic behaviour of $$w^2$$

w
2

, which differs from results in the literature. It is confirmed by Monte Carlo simulations.
Learning from failure at the science–policy interface for climate action in agriculture
Authors: Dinesh Dhanush , Hegger Dries , Vervoort Joost , Campbell Bruce M. , Driessen Peter P. J. 
Published: March 2021

AbstractScience–policy engagement efforts to accelerate climate action in agricultural systems are key to enable the sector to contribute to climate and food security goals. However, lessons to improve science–policy engagement efforts in this context mostly come from successful efforts and are limited in terms of empirical scope. Moreover, lessons have not been generated systematically from failed science–policy engagement efforts. Such analysis using lessons from failure management can improve or even transform the efficacy of efforts. To address this knowledge gap, we examined challenges and failures faced in science–policy engagement efforts of the CGIAR Research Program on Climate Change, Agriculture and Food Security (CCAFS). We developed an explanatory framework inspired by Cash et al.’s criteria for successful knowledge systems for sustainable development: credibility, salience, and legitimacy, complemented with insights from the wider literature. Using this framework in a survey, we identified factors which explain failure. To effectively manage these factors, we propose a novel approach for researchers working at the science–policy interface to fail intelligently, which involves planning for failure, minimizing risks, effective design, making failures visible, and learning from failures. This approach needs to be complemented by actions at the knowledge system level to create an enabling environment for science–policy interfaces.
On the trade-offs and synergies between forest carbon sequestration and substitution
Authors: Soimakallio Sampo , Kalliokoski Tuomo , Lehtonen Aleksi , Salminen Olli 
Published: March 2021

AbstractForest biomass can be used in two different ways to limit the growth of the atmospheric greenhouse gas (GHG) concentrations: (1) to provide negative emissions through sequestration of carbon into forests and harvested wood products or (2) to avoid GHG emissions through substitution of non-renewable raw materials with wood. We study the trade-offs and synergies between these strategies using three different Finnish national-level forest scenarios between 2015 and 2044 as examples. We demonstrate how GHG emissions change when wood harvest rates are increased. We take into account CO2 and other greenhouse gas flows in the forest, the decay rate of harvested wood products and fossil-based CO2 emissions that can be avoided by substituting alternative materials with wood derived from increased harvests. We considered uncertainties of key parameters by using stochastic simulation. According to our results, an increase in harvest rates in Finland increased the total net GHG flow to the atmosphere virtually certainly or very likely, given the uncertainties and time frame considered. This was because the increased biomass-based CO2 and other greenhouse gas emissions to the atmosphere together with decreased carbon sequestration into the forest were very likely higher than the avoided fossil-based CO2 emissions. The reverse of this conclusion would require that compared to what was studied in this paper, the share of long-living wood products in the product mix would be higher, carbon dioxide from bioenergy production would be captured and stored, and reduction in forest carbon equivalent net sink due to wood harvesting would be minimized.
Granzyme B PET Imaging of Combined Chemotherapy and Immune Checkpoint Inhibitor Therapy in Colon Cancer
Authors: Goggi Julian L , Hartimath Siddesh V , Xuan Tan Yun , Khanapur Shivashankar , Jieu Beverly , Chin Hui Xian , Ramasamy Boominathan , Cheng Peter , Rong Tang Jun , Fong Yong Fui , Yuen Tsz Ying , Msallam Rasha , Chacko Ann-Marie , Renia Laurent , Johannes Charles , Hwang You Yi , Robins Edward G 
Published: March 2021

Abstract
Purpose
Chemotherapeutic adjuvants, such as oxaliplatin (OXA) and 5-fluorouracil (5-FU), that enhance the immune system, are being assessed as strategies to improve durable response rates when used in combination with immune checkpoint inhibitor (ICI) monotherapy in cancer patients. In this study, we explored granzyme B (GZB), released by tumor-associated immune cells, as a PET imaging-based stratification marker for successful combination therapy using a fluorine-18 (18F)-labelled GZB peptide ([18F]AlF-mNOTA-GZP).

Methods
Using the immunocompetent CT26 syngeneic mouse model of colon cancer, we assessed the potential for [18F]AlF-mNOTA-GZP to stratify OXA/5-FU and ICI combination therapy response via GZB PET. In vivo tumor uptake of [18F]AlF-mNOTA-GZP in different treatment arms was quantified by PET, and linked to differences in tumor-associated immune cell populations defined by using multicolour flow cytometry.

Results
[18F]AlF-mNOTA-GZP tumor uptake was able to clearly differentiate treatment responders from non-responders when stratified based on changes in tumor volume. Furthermore, [18F]AlF-mNOTA-GZP showed positive associations with changes in tumor-associated lymphocytes expressing GZB, namely GZB+ CD8+ T cells and GZB+ NK+ cells.

Conclusions
[18F]AlF-mNOTA-GZP tumor uptake, driven by changes in immune cell populations expressing GZB, is able to stratify tumor response to chemotherapeutics combined with ICIs. Our results show that, while the immunomodulatory mode of action of the chemotherapies may be different, the ultimate mechanism of tumor lysis through release of Granzyme B is an accurate biomarker for treatment response.
The braingraph.org database with more than 1000 robust human connectomes in five resolutions
Authors: Varga Bálint , Grolmusz Vince 
Published: March 2021

AbstractThe human brain is the most complex object of study we encounter today. Mapping the neuronal-level connections between the more than 80 billion neurons in the brain is a hopeless task for science. By the recent advancement of magnetic resonance imaging (MRI), we are able to map the macroscopic connections between about 1000 brain areas. The MRI data acquisition and the subsequent algorithmic workflow contain several complex steps, where errors can occur. In the present contribution we describe and publish 1064 human connectomes, computed from the public release of the Human Connectome Project. Each connectome is available in 5 resolutions, with 83, 129, 234, 463 and 1015 anatomically labeled nodes. For error correction we follow an averaging and extreme value deleting strategy for each edge and for each connectome. The resulting 5320 braingraphs can be downloaded from the https://braingraph.org site. This dataset makes possible the access to this graphs for scientists unfamiliar with neuroimaging- and connectome-related tools: mathematicians, physicists and engineers can use their expertize and ideas in the analysis of the connections of the human brain. Brain scientists and computational neuroscientists also have a robust and large, multi-resolution set for connectomical studies.
D-optimal designs for Poisson regression with synergetic interaction effect
Authors: Freise Fritjof , Graßhoff Ulrike , Röttger Frank , Schwabe Rainer 
Published: March 2021

AbstractWe characterizeD-optimal designs in the two-dimensional Poisson regression model with synergetic interaction and provide an explicit proof. The proof is based on the idea of reparameterization of the design region in terms of contours of constant intensity. This approach leads to a substantial reduction in complexity as properties of the sensitivity can be treated along and across the contours separately. Furthermore, some extensions of this result to higher dimensions are presented.
Bioinspired and biomimetic membranes for water purification and chemical separation: A review
Authors: Abaie Elham , Xu Limeimei , Shen Yue-xiao 
Published: March 2021

AbstractBioinspired and biomimetic membranes that contain biological transport channels or attain their structural designs from biological systems have been through a remarkable development over the last two decades. They take advantage of the exceptional transport properties of those channels, thus possess both high permeability and selectivity, and have emerged as a promising solution to existing membranes. Since the discovery of biological water channel proteins aquaporins (AQPs), extensive efforts have been made to utilize them to make separation membranes-AQP-based membranes, which have been commercialized. The exploration of AQPs’ unique structures and transport properties has resulted in the evolution of biomimetic separation materials from protein-based to artificial channel-based membranes. However, large-scale, defect-free biomimetic membranes are not available yet. This paper reviews the state-of-the-art biomimetic membranes and summarizes the latest research progress, platform, and methodology. Then it critically discusses the potential routes of this emerging area toward scalable applications. We conclude that an appropriate combination of bioinspired concepts and molecular engineering with mature polymer industry may lead to scalable polymeric membranes with intrinsic selective channels, which will gain the merit of both desired selectivity and scalability.