bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond basic psychological needs: The hope construct during adjuvant treatment in colorectal cancer patients
Authors: Romero-Elías María , González-Cutre David , Beltrán-Carrillo Vicente J. , Jiménez-Loaisa Alejandro 
Published: March 2021

AbstractThis study explored basic psychological needs (BPN) experiences, motivation to continue living, and psychological well-being in colorectal cancer (CRC) patients during adjuvant treatment. Qualitative data from 30 participants (ten CRC patients, ten relatives and ten healthcare professionals) were collected by performing two sets of semi-structured interviews. Three categories were identified: (a) BPN frustration, (b) hope as a source of motivation, and (c) sources of hope. This last category included several subcategories: positive attitude, religious faith, positive medical feedback, knowing that they were going to receive a short-term chemotherapy, and being aware that other patients were in a worse condition. CRC patients felt their basic psychological needs were thwarted during adjuvant treatment. However, hopeful thoughts were reported as relevant sources of motivation to live, which positively impacted on patients’ psychological well-being. Future research could explore the construct of hope as a hypothetical moderator between BPN and CRC patients’ well-being during treatment.
Lange nicht-codierende RNAs in der Angiogenese
Authors: Brandes Ralf P. , Leisegang Matthias S. 
Published: March 2021

AbstractMore than 97 percent of the transcribed RNA in mammalian cells is not coding for proteins. Among these are micro RNAs (miRs), transfer RNAs (tRNA) as well as ribosomal RNAs (rRNA) but also long non-coding RNAs (lncRNAs). This RNA class is only defined by its sequence length of more than 200 nucleotides and its lack of protein coding potential. The human genome encodes for more than 18.000 lncRNAs which contribute to gene expression control. Here, we discuss the function of these lncRNAs and how they modulate the angiogenic process of vessel growth.
Makrophagen in der Krankheitsentstehung und Therapie
Authors: Lachmann Nico 
Published: March 2021

AbstractMacrophages are unique cells of the innate immunity and can be found in various tissues (tissue resident macrophages; TRMs). Macrophages and TRMs play a pivotal role in tissue homeostasis and can contribute to the onset and progression of certain diseases. We and others have developed macrophage-based cellular immunotherapies and explored the field of immune cell farming using induced pluripotent stem cells (iPSCs). Combination of iPSCs and bioreactors opens new ways in cellular therapies.
Clinicopathological factors and survival outcomes of signet-ring cell and mucinous carcinoma versus adenocarcinoma of the colon and rectum: a systematic review and meta-analysis
Authors: Fadel Michael G. , Malietzis George , Constantinides Vasilis , Pellino Gianluca , Tekkis Paris , Kontovounisios Christos 
Published: March 2021

Abstract
Background
Histological subtypes of colorectal cancer may be associated with varied prognostic features. This systematic review and meta-analysis aimed to compare clinicopathological characteristics, recurrence and overall survival between colorectal signet-ring cell (SC) and mucinous carcinoma (MC) to conventional adenocarcinoma (AC).

Methods
A literature search of MEDLINE, EMBASE, Ovid and Cochrane Library was performed for studies that reported data on clinicopathological and survival outcomes on SC and/or MC versus AC from January 1985 to May 2020. Meta-analysis was performed using random-effect models and between-study heterogeneity was assessed.

Results
Thirty studies of 1,087,055 patients were included: 11,510 (1.06%) with SC, 110,179 (10.13%) with MC and 965,366 (88.81%) with AC. Patients with SC were younger than patients with AC (WMD − 0.47; 95% CI − 0.84 to –0.10; I2 88.6%; p = 0.014) and more likely to have right-sided disease (OR 2.12; 95% CI 1.72–2.60; I2 82.9%; p < 0.001). Locoregional recurrence at 5 years was more frequent in patients with SC (OR 2.81; 95% CI 1.40–5.65; I2 0.0%; p = 0.004) and MC (OR 1.92; 95% CI 1.18–3.15; I2 74.0%; p = 0.009). 5-year overall survival was significantly reduced when comparing SC and MC to AC (HR 2.54; 95% CI 1.98–3.27; I2 99.1%; p < 0.001 and HR 1.38; 95% CI 1.19–1.61; I2 98.6%; p < 0.001, respectively).

Conclusion
SC and MC are associated with right-sided lesions, advanced stage at presentation, higher rates of recurrence and poorer overall survival. This has strong implications towards surgical and oncological management and surveillance of colorectal cancer.
New immunological potential markers for triple negative breast cancer: IL18R1, CD53, TRIM, Jaw1, LTB, PTPRCAP
Authors: Marchetti Paolo , Antonov Alexey , Anemona Lucia , Vangapandou Chaitania , Montanaro Manuela , Botticelli Andrea , Mauriello Alessandro , Melino Gerry , Catani M. Valeria 
Published: March 2021

AbstractBreast cancer (BC) is the second leading cause of cancer death in women worldwide, and settings of specific prognostic factors and efficacious therapies are made difficult by phenotypic heterogeneity of BC subtypes. Therefore, there is a current urgent need to define novel predictive genetic predictors that may be useful for stratifying patients with distinct prognostic outcomes. Here, we looked for novel molecular signatures for triple negative breast cancers (TNBCs). By a bioinformatic approach, we identified a panel of genes, whose expression was positively correlated with disease-free survival in TNBC patients, namely IL18R1, CD53, TRIM, Jaw1, LTB, and PTPRCAP, showing specific immune expression profiles linked to survival prediction; most of these genes are indeed expressed in immune cells and are required for productive lymphocyte activation. According to our hypothesis, these genes were not, or poorly, expressed in different TNBC cell lines, derived from either primary breast tumours or metastatic pleural effusions. This conclusion was further supported in vivo, as immuno-histochemical analysis on biopsies of TNBC invasive ductal carcinomas highlighted differential expression of these six genes in cancer cells, as well as in intra- and peri-tumoral infiltrating lymphocytes. Our data open to the possibility that inter-tumour heterogeneity of immune markers might have predictive value; further investigations are recommended in order to establish the real power of cancer-related immune profiles as prognostic factors.
Wi-fi related radiofrequency electromagnetic fields (RF-EMF): a pilot experimental study of personal exposure and risk perception
Authors: Zeleke Berihun M. , Brzozek Christopher , Bhatt Chhavi R. , Abramson Michael J. , Freudenstein Frederik , Croft Rodney J. , Wiedemann Peter , Benke Geza 
Published: March 2021

AbstractThe impact of providing people with an objectively measured personal radiofrequency electromagnetic fields (RF-EMF) exposure information on the risk perception of people is not well understood. We conducted an experimental study, among three groups of participants, to investigate the risk perception of people towards RF-EMF from Wi-Fi sources (ISM 2.4 GHz) by providing participants with either basic text, precautionary information, or a summary of their personal RF-EMF exposure measurement levels. Participants provided with personal RF-EMF exposure measurement information were more confident in protecting themselves from RF-EMF exposure, compared to those provided with only basic information. Nonetheless, neither the exposure perception nor the risk perception of people to Wi-Fi related RF-EMF differed by the type of information provided. The measured Wi-Fi signal levels were far below international exposure limits. Furthermore, self-rated levels of personal RF-EMF exposure perception were not associated with objectively measured RF-EMF exposure levels. Providing people with objectively measured information may help them build confidence in protecting themselves from Wi-Fi related RF-EMF exposure.
Cardiac Regeneration: the Heart of the Issue
Authors: Carotenuto Felicia , Manzari Vittorio , Di Nardo Paolo 
Published: March 2021

Abstract
Purpose of Review
The regenerative capacity of the heart is insufficient to compensate for the pathological loss of cardiomyocytes during a large injury, such as a myocardial infarction. Therapeutic options for patients after cardiac infarction are limited: treatment with drugs that only treat the symptoms or extraordinary measures, such as heart transplantation. Cell therapies offer a promising strategy for cardiac regeneration. In this brief review, the major issues in these areas are discussed, and possible directions for future research are indicated.

Recent Findings
Cardiac regeneration can be obtained by at least two strategies: the first is direct to generate an ex vivo functional myocardial tissue that replaces damaged tissue; the second approach aims to stimulate endogenous mechanisms of cardiac repair. However, current cell therapies are still hampered by poor translation into actual clinical applications.

Summary
In this scenario, recent advancements in cell biology and biomaterial-based technologies can play a key role to design effective therapeutic approaches.
Cultivating the Ethical Repertoires of Behavior Analysts: Prevention of Common Violations
Authors: Britton Lisa N. , Crye Amy A. , Haymes Linda K. 
Published: March 2021

AbstractViolations of the Professional and Ethical Compliance Code for Behavior Analysts occur despite coursework, supervision, and training. In this discussion, we highlight the most common violation categories identified: (a) improper or inadequate supervision/delegation, (b) failure to report/respond to the Behavior Analyst Certification Board (BACB) as required, and (c) professionalism/integrity. The specific areas addressed under supervision/delegation involve behavior analysts’ standards and performance as supervisors, as well as compliance with coursework. For failure to report, the focus is on responding, reporting, and providing updated information to the BACB in a timely manner. Finally, the section on professionalism and integrity addresses multiple code elements, including integrity, professionalism, and scientific relationships, as well as methods for promoting an ethical culture and decisions involving ethical violations by others. Importantly, we provide guidance on the structure and organization of supervision, methods and guidelines regarding reporting, and rubrics to shape and evaluate professionalism and integrity. We provide recommendations for the supervision process and for practitioners from the organizational perspective so that the organization supports and promotes an ethical culture.
A tractor-trailer parking control scheme using adaptive dynamic programming
Authors: Guan Chenyong , Jiang Yu 
Published: March 2021

AbstractThis paper studies the online learning control of a truck-trailer parking problem via adaptive dynamic programming (ADP). The contribution is twofold. First, a novel ADP method is developed for systems with parametric nonlinearities. It learns the optimal control policy of the linearized system at the origin, while the learning process utilizes online measurements of the full system and is robust with respect to nonlinear disturbances. Second, a control strategy is formulated for a commonly seen truck-trailer parallel parking problem, and the proposed ADP method is integrated into the strategy to provide online learning capabilities and to handle uncertainties. A numerical simulation is conducted to demonstrate the effectiveness of the proposed methodology.
Anytime and Efficient Multi-agent Coordination for Disaster Response
Authors: Capezzuto Luca , Tarapore Danesh , Ramchurn Sarvapali D. 
Published: March 2021

AbstractTheCoalition Formation with Spatial and Temporal constraints Problem(CFSTP) is a multi-agent task allocation problem where the tasks are spatially distributed, with deadlines and workloads, and the number of agents is typically much smaller than the number of tasks. To maximise the number of completed tasks, the agents may have to schedule coalitions. The state-of-the-art CFSTP solver, theCoalition Formation with Look-Ahead(CFLA) algorithm, has two main limitations. First, its time complexity is exponential with the number of agents. Second, as we show, its look-ahead technique is not effective in real-world scenarios, such as open multi-agent systems, where new tasks can appear at any time. In this work, we study its design and define a variant, calledCoalition Formation with Improved Look-Ahead($$\text {CFLA}2$$CFLA2), which achieves better performance. Since we cannot eliminate the limitations of CFLA in$$\text {CFLA}2$$CFLA2, we also develop a novel algorithm to solve the CFSTP, the first to be simultaneously anytime, efficient and with convergence guarantee, calledCluster-based Task Scheduling(CTS). In tests where the look-ahead technique is highly effective, CTS completes up to$$30\%$$30%(resp.$$10\%$$10%) more tasks than CFLA (resp.$$\text {CFLA}2$$CFLA2) while being up to 4 orders of magnitude faster. We also propose S-CTS, a simplified but parallel variant of CTS with even lower time complexity. Using scenarios generated by the RoboCup Rescue Simulation, we show that S-CTS is at most$$10\%$$10%less performing than high-performance algorithms such as Binary Max-Sum and DSA, but up to 2 orders of magnitude faster. Our results affirm CTS as the new state-of-the-art algorithm to solve the CFSTP.
A Modified Pressure Dressing to Avoid Severe Bleeding After Circumcision With a Disposable Circumcision Suture Device and a Discussion on the Mechanism of Bleeding With the Disposable Circumcision Suture Device
Authors: Jiang Wei , Fu Jia-li , Guo Wen-liang , Yan Zai-chun , Zheng Ru-qiang , Lu Ji-ru , Lai Xiao-dong 
Published: March 2021

AbstractIntroductionA novel type of a disposable circumcision suture device (DCSD) has been proved to be effective and safe; however, a few cases of severe bleeding took place after circumcisions.AimTo evaluate the effectiveness of a modified double-layer pressure dressing to avoid severe bleeding after circumcision with the DCSD, in our department in a prospective randomized controlled study, and discuss the mechanism of bleeding with DCSD.MethodsPatients with redundant foreskin or phimosis were included between September 2018 and November 2019 and divided into 2 groups: In group A, the conventional pressure dressing was performed; in group B, an modified double-layer pressure dressing was performed.Main Outcome MeasureThe main outcomes and complications (surgical time, incidence of glans ischemia, severe bleeding rate, infection rate, pain level, total cost, and overall satisfaction) were collected and analyzed.ResultsA total of 624 patients were recruited for this study. There was no difference in the average age and body mass index between 2 groups. No patient suffered obvious glans ischemia. In group B, lower pain level, lower incidences of severe bleeding, and better satisfaction were recorded.ConclusionThe mechanism of bleeding with the DCSD was discussed in this study, and the modified pressure dressing was proved effective, safe, and easy to perform.
THE NEKSELØ FISH WEIR AND MARINE RESERVOIR EFFECT IN NEOLITHIZATION PERIOD DENMARK
Authors: Fischer Anders , Olsen Jesper 
Published: March 2021

ABSTRACTThe Nekselø Wickerwork provides an unusually solid estimate on the marine reservoir age in the Holocene. The basis for this result is a 5200-year-old fish weir, built of hazel wood with a brief biological age of its own. Oysters settled on this construction. They had lived only for a short number of years when the fence capsized and was covered in mud and the mollusks suffocated. Based on the difference in radiocarbon (14C) age between accelerator mass spectrometry (AMS) samples of oyster shells and wood, respectively, the marine reservoir age for this site is estimated to 273 ± 18 14C years. Re-evaluations of previously produced data from geological and archaeological sites of Holocene date in the Danish archipelago indicate marine reservoir ages in the same order as that of the Wickerwork. Consequently, we recommend the use of the new value, rather than the ca. 400 14C years hitherto favored, when correcting for the dietary induced reservoir effect in radiocarbon dates of humans and animals from the Late Mesolithic and Early Neolithic periods of this region.
TEXTUAL NOTES ON PS.-DIOSCORIDES, ON SIMPLES
Authors: Fitch John G. 
Published: March 2021

AbstractThis article discusses the text of the work On Simples attributed to Dioscorides. It argues that in fifteen places the transmitted text is faulty, and it proposes emendations. It also studies certain types of insertions made in the text by its most recent editor, Max Wellmann, and concludes that they are unnecessary. Finally, it discusses two points where On Simples sheds light on Dioscorides’ De materia medica.
The Normative Influence of the UN Guiding Principles on the Kampala Convention in the Protection of Internally Displaced Persons in Africa
Authors: Deng Francis M , Adeola Romola 
Published: March 2021

AbstractOver the last several decades, states have demonstrated significant political commitment towards advancing protection and assistance for internally displaced persons. A notable form in which this commitment has been reflected is in the emergence of normative standards, with the UN Guiding Principles on Internal Displacement (UNGP) as the guiding text. The fact that the UNGP framework has found expression in the landscape on internal displacement is evidenced at various levels of governance. Within the African context, the African Union Convention for the Protection and Assistance of Internally Displaced Persons in Africa (Kampala Convention) draws on pertinent normative frameworks, with the UNGP as the leading framework. While this point is often made in general terms, this article focuses on the extent to which the norm on internal displacement has diffused and expanded within the African context.
Effect of coronavirus disease 2019 on recurrences and follow up of head and neck squamous cell carcinoma
Authors: Kytö E , Haapio E , Kinnunen I , Irjala H 
Published: March 2021

AbstractObjectiveThis prospective study aimed to evaluate possible diagnostic delays in head and neck squamous cell carcinoma recurrences due to the changed follow-up protocol during the coronavirus disease 2019 pandemic.MethodsThe follow-up appointments of head and neck squamous cell carcinoma patients treated more than one year prior to the pandemic were changed to telephone appointments in order to reduce physical visits to the hospital. All contacts, reasons for contact and recurrent cancers were recorded.ResultsThere were 17 recurrences during a seven-month study period among 178 patients treated in the previous year (10 per cent); 14 of these recurrences occurred in patients whose treatment had ended less than one year previously and 3 occurred more than one year after treatment had ended. There was no delay in diagnoses of recurrent tumours or treatment despite reduced visits because of the coronavirus disease 2019 pandemic.ConclusionAccording to our analyses, no delay was caused in the diagnoses of recurrent diseases. Follow up by telephone or telemedicine can be considered as part of the follow-up protocol one year after the treatment of head and neck squamous cell carcinoma when necessary.
Gambling activity in the old-age general population
Authors: del Pino-Gutiérrez Amparo , Granero Roser , Fernández-Aranda Fernando , Mena-Moreno Teresa , Mestre-Bach Gemma , Gómez-Peña Mónica , Moragas Laura , Aymamí Neus , Giroux Isabelle , Grall-Bronnec Marie , Sauvaget Anne , Codina Ester , Vintró-Alcaraz Cristina , Lozano-Madrid María , Agüera Zaida , Sánchez-González Jéssica , Casalé Gemma , Baenas Isabel , Sánchez Isabel , López-González Hibai , Menchón José M. , Jiménez-Murcia Susana 
Published: March 2021

AbstractOld age constitutes a vulnerable stage for developing gambling-related problems. The aims of the study were to identify patterns of gambling habits in elderly participants from the general population, and to assess socio-demographic and clinical variables related to the severity of the gambling behaviours. The sample included N = 361 participants aged in the 50–90 years range. A broad assessment included socio-demographic variables, gambling profile and psychopathological state. The percentage of participants who reported an absence of gambling activities was 35.5 per cent, while 46.0 per cent reported only non-strategic gambling, 2.2 per cent only strategic gambling and 16.3 per cent both non-strategic plus strategic gambling. Gambling form with highest prevalence was lotteries (60.4%), followed by pools (13.9%) and bingo (11.9%). The prevalence of gambling disorder was 1.4 per cent, and 8.0 per cent of participants were at a problematic gambling level. Onset of gambling activities was younger for men, and male participants also reached a higher mean for the bets per gambling-episode and the number of total gambling activities. Risk factors for gambling severity in the sample were not being born in Spain and a higher number of cumulative lifetime life events, and gambling severity was associated with a higher prevalence of tobacco and alcohol abuse and with worse psychopathological state. Results are particularly useful for the development of reliable screening tools and for the design of effective prevention programmes.
Synergy between callous–unemotional traits and aggression in preschool children: Cross-informant and cross-cultural replication in the UK Wirral Child Health and Development Study, and the Colombian La Sabana Parent–Child Study
Authors: Obando D. , Hill J. , Sharp H. , Pickles A. , Fisher L. , Wright N. 
Published: March 2021

AbstractIncremental prediction of aggression from callous–unemotional (CU) traits is well established, but cross-cultural replication and studies of young children are needed. Little is understood about the contribution of CU traits in children who are already aggressive. We addressed these issues in prospective studies in the United Kingdom and Colombia. In a UK epidemiological cohort, CU traits and aggression were assessed at age 3.5 years, and aggression at 5.0 years by mothers (N = 687) and partners (N = 397). In a Colombian general population sample, CU traits were assessed at age 3.5 years and aggression at 3.5 and 5.0 years by mother report (N = 220). Analyses consistently showed prediction of age-5.0 aggression by age-3.5 CU traits controlling for age-3.5 aggression. Associations between age-3.5 CU traits and age-5.0 aggression were moderated by aggression at 3.5 years, with UK interaction terms, same informant, β = .07 p = .014 cross-informant, β = .14 p = .002, and in Colombia, β = .09 p = .128. The interactions arose from stronger associations between CU traits and later aggression in those already aggressive. Our findings with preschoolers replicated across culturally diverse settings imply a major role for CU traits in the maintenance and amplification of already established aggression, and cast doubt on their contribution to its origins.