bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Privacy-Preserving Log-Rank Test for the Kaplan-Meier Estimator With Secure Multiparty Computation: Algorithm Development and Validation
Authors: von Maltitz Marcel , Ballhausen Hendrik , Kaul David , Fleischmann Daniel F , Niyazi Maximilian , Belka Claus , Carle Georg 
Published: January 2021

Background
Patient data is considered particularly sensitive personal data. Privacy regulations strictly govern the use of patient data and restrict their exchange. However, medical research can benefit from multicentric studies in which patient data from different institutions are pooled and evaluated together. Thus, the goals of data utilization and data protection are in conflict. Secure multiparty computation (SMPC) solves this conflict because it allows direct computation on distributed proprietary data—held by different data owners—in a secure way without exchanging private data.

Objective
The objective of this work was to provide a proof-of-principle of secure and privacy-preserving multicentric computation by SMPC with real-patient data over the free internet. A privacy-preserving log-rank test for the Kaplan-Meier estimator was implemented and tested in both an experimental setting and a real-world setting between two university hospitals.

Methods
The domain of survival analysis is particularly relevant in clinical research. For the Kaplan-Meier estimator, we provided a secure version of the log-rank test. It was based on the SMPC realization SPDZ and implemented via the FRESCO framework in Java. The complexity of the algorithm was explored both for synthetic data and for real-patient data in a proof-of-principle over the internet between two clinical institutions located in Munich and Berlin, Germany.

Results
We obtained a functional realization of an SMPC-based log-rank evaluation. This implementation was assessed with respect to performance and scaling behavior. We showed that network latency strongly influences execution time of our solution. Furthermore, we identified a lower bound of 2 Mbit/s for the transmission rate that has to be fulfilled for unimpeded communication. In contrast, performance of the participating parties have comparatively low influence on execution speed, since the peer-side processing is parallelized and the computational time only constitutes 30% to 50% even with optimal network settings. In the real-world setting, our computation between three parties over the internet, processing 100 items each, took approximately 20 minutes.

Conclusions
We showed that SMPC is applicable in the medical domain. A secure version of commonly used evaluation methods for clinical studies is possible with current implementations of SMPC. Furthermore, we infer that its application is practically feasible in terms of execution time.
Emotional Reactions and Likelihood of Response to Questions Designed for a Mental Health Chatbot Among Adolescents: Experimental Study
Authors: Mariamo Audrey , Temcheff Caroline Elizabeth , Léger Pierre-Majorique , Senecal Sylvain , Lau Marianne Alexandra 
Published: January 2021

BackgroundPsychological distress increases across adolescence and has been associated with several important health outcomes with consequences that can extend into adulthood. One type of technological innovation that may serve as a unique intervention for youth experiencing psychological distress is the conversational agent, otherwise known as a chatbot. Further research is needed on the factors that may make mental health chatbots destined for adolescents more appealing and increase the likelihood that adolescents will use them.ObjectiveThe aim of this study was to assess adolescents’ emotional reactions and likelihood of responding to questions that could be posed by a mental health chatbot. Understanding adolescent preferences and factors that could increase adolescents’ likelihood of responding to chatbot questions could assist in future mental health chatbot design destined for youth.MethodsWe recruited 19 adolescents aged 14 to 17 years to participate in a study with a 2×2×3 within-subjects factorial design. Each participant was sequentially presented with 96 chatbot questions for a duration of 8 seconds per question. Following each presentation, participants were asked to indicate how likely they were to respond to the question, as well as their perceived affective reaction to the question. Demographic data were collected, and an informal debriefing was conducted with each participant.ResultsParticipants were an average of 15.3 years old (SD 1.00) and mostly female (11/19, 58%). Logistic regressions showed that the presence of GIFs predicted perceived emotional valence (β=–.40, P<.001), such that questions without GIFs were associated with a negative perceived emotional valence. Question type predicted emotional valence, such that yes/no questions (β=–.23, P=.03) and open-ended questions (β=–.26, P=.01) were associated with a negative perceived emotional valence compared to multiple response choice questions. Question type also predicted the likelihood of response, such that yes/no questions were associated with a lower likelihood of response compared to multiple response choice questions (β=–.24, P=.03) and a higher likelihood of response compared to open-ended questions (β=.54, P<.001).ConclusionsThe findings of this study add to the rapidly growing field of teen-computer interaction and contribute to our understanding of adolescent user experience in their interactions with a mental health chatbot. The insights gained from this study may be of assistance to developers and designers of mental health chatbots.
Variability in Culture-Negative Peritonitis Rates in Pediatric Peritoneal Dialysis Programs in the United States
Authors: Davis T. Keefe , Bryant Kristina A. , Rodean Jonathan , Richardson Troy , Selvarangan Rangaraj , Qin Xuan , Neu Alicia , Warady Bradley A. 
Published: January 2021

Background and objectives
International guidelines suggest a target culture-negative peritonitis rate of <15% among patients receiving long-term peritoneal dialysis. Through a pediatric multicenter dialysis collaborative, we identified variable rates of culture-negative peritonitis among participating centers. We sought to evaluate whether specific practices are associated with the variability in culture-negative rates between low– and high–culture-negative rate centers.

Design, setting, participants, & measurements
Thirty-two pediatric dialysis centers within the Standardizing Care to Improve Outcomes in Pediatric End Stage Renal Disease (SCOPE) collaborative contributed prospective peritonitis data between October 1, 2011 and March 30, 2017. Clinical practice and patient characteristics were compared between centers with a ≤20% rate of culture-negative peritonitis (low-rate centers) and centers with a rate >20% (high-rate centers). In addition, centers completed a survey focused on center-specific peritoneal dialysis effluent culture techniques.

Results
During the 5.5 years of observation, 1113 patients had 1301 catheters placed, totaling 19,025 patient months. There were 620 episodes of peritonitis in 378 patients with 411 catheters; cultures were negative in 165 (27%) peritonitis episodes from 125 (33%) patients and 128 (31%) catheters. Low-rate centers more frequently placed catheters with a downward-facing exit site and two cuffs (P<0.001), whereas high-rate centers had more patients perform dialysis themselves without the assistance of an adult care provider (P<0.001). The survey demonstrated that peritoneal dialysis effluent culture techniques were highly variable across centers. No consistent practice or technique helped to differentiate low- and high-rate centers.

Conclusions
Culture-negative peritonitis is a frequent complication of maintenance peritoneal dialysis in children. Despite published recommendations for dialysis effluent collection and culture methods, great variability in culture techniques and procedures exists among individual dialysis programs and respective laboratory processes.
Formulation and In Vitro Evaluation of Bilayer Tablets of Lansoprazole and Amoxycillin Trihydrate for the Treatment of Peptic Ulcer
Authors: Singh Neha , Pandey Durga , Jain Nilesh , Jain Surendra 
Published: January 2021

The present work involves the formulation development, optimization and In-vitro evaluation of bilayer tablet containing Lansoprazole in the immediate release layer and Amoxycillin in the sustained release layer, using sodium starch glycolate as a super disintegrant for the immediate release layer and the hydrophilic matrix HPMC K100M, hydrophobic matrix Ethyl cellulose are used in the sustained release layer. Bilayer tablet showed as initial burst effect to provide dose of immediate release layer Lansoprazole to control the acid secretion level and the sustained release of Amoxycillin for 24 hours. Immediate and sustained release tablets were formulated by wet granulation method because of the poor flow property of the blends. The prepared bilayer tablet was evaluated for their precompression parameters, physical characteristics like hardness, friability, uniformity of weight, uniformity of drug content, swelling index, In-vitro floating studies and In-vitro drug release. The release of the lansoprazole from the immediate release layer was found to be 97.46 ± 0.15% in 15minutes. The release of Amoxycillin Trihydrate for the sustained release floating layer was found to be 98.25 ± 0.14% in 12 hours. Lansoprazole potentiate the effect of Amoxycillin. Hence the bilayer tablets of Lansoprazole and Amoxycillin were used to improve patient compliance towards the effective management of ulcer. Keywords: bilayer tablet, Lansoprazole, and Amoxycillin, sustained release
Respiratory function test data and maximum oxygen consumption of children playing football in a hot and humid environment
Authors: BAZABA KAYILOU Jean Michel , AHOUNOU AΪPE Judith , MOUKOUMBI MABIKA Ghislain Aymard 
Published: January 2021

Nowadays, the achievement of a good sporting performance depends on a good development of physical capacities from a young age while respecting the different stages of growth. In spite of this, some football coaches and trainers have no mastery of the principles of training. They subject children to physical effort that does not correspond to the child's developmental stages. In order to evaluate the respiratory function and maximum oxygen consumption of children trained in football, series of test matches were organised by age group under a temperature of 38°C and a humidity of 60%. The results of the study show an increase in maximum oxygen consumption according to age with extremes of 36, 54 ml/min/kg and 55, 99 ml/min/kg. The classification of the values of V ̇O2max according to the spirometry values shows a representativeness of 13-14 year old children in the class of low spirometry values (CV, FEV1 and DEP) and a strong representativeness of 16-17 year old children in the class of high spirometry values (CV, FEV1 and DEP). A correlation exists between maximum oxygen consumption, spirometry equations and anthropometric parameters during the growth of children playing football. Keywords: Training, children, football, spirometry, Congo (Brazzaville)
KARAKTERISASI RIZOBAKTERI YANG BERPOTENSI MENGENDALIKAN BAKTERI Xanthomonas oryzae pv. oryzae DAN MENINGKATKAN PERTUMBUHAN TANAMAN PADI
Authors: Agustiansyah Agustiansyah , Ilyas Satriyas , Sudarsono Sudarsono , Machmud Muhammad 
Published: January 2021

Characterization of rhizobacteri having potential to control Xanthomonas oryzae pv. oryzae and increase plant growth of rice. Rhizobacteria which are isolated from root could produce HCN, siderophore, and plant growth regulator, induce systemic resistance, and are increase uptake of plant nutrition such as phosphate. The objective of this research was to characterize rhizobacteri as controling agent for Xanthomonas oryzae pv.oryzae (Xoo) and as plant growth promoter. The results show that the isolates of P. diminuta A6, P. aeruginosa A54, B.subtilis 11 /C, and B. subtilis 5/B inhibited the growth of Xoo. B. subtilis 5/B isolate produced the highest siderophore activity, followed by of P. aeruginosa A54, P. diminuta A6 and B. subtilis 11/C. Only P. diminuta A6 isolate produced HCN. The results also showed that all rhizobacteri produced IAA i.e. B.subtilis 5/B (22.10 µg/ml), B. subtilis 11/C (19.05 µg/ml), P. diminuta A6 (8.68 ug/ml), and P. aeruginosa A54 (2.95 µg/ml). The content of phosphatase enzyme was as folows B.subtilis 5/B (2.78 units/ ml), B.subtilis 11/C (5.7 units/ml), P. diminuta A6 (2.25 units/ml), and P. aeruginosa A54 (5.71 units / ml). Content of peroxidase enzymes in plants that were treated by using isolates was as follows B.subtilis 5/B (1.30 x 10-3 units/mg protein), P. aeruginosa A6 (1.20 x 10-3 units/mg protein), B.subtilis 11/C (1.15 x 10-3 units/mg protein), and P. aeruginosa A54 (1.05 x 10-3 units/mg protein).
SPESIES PARASITOID LIPAPHIS ERYSIMI ASAL SUMATERA SELATAN DAN VARIASI PARASITISASINYA PADA TUMBUHAN INANG YANG BERBEDA
Authors: Herlinda Siti , Anggraini Erise , Irsan Chandra , Umayah Abu , Thalib Rosdah , Adam Triani 
Published: January 2021

Lipaphis erysimi (Hemiptera: Aphididae) is one of the main insect pests on brassicaceous crops. Aphids attack crops by sucking sap from its hosts. Densed population in the initial phase of crop growth could inhibit growing, loss in yield up to 100%. Experiments were aimed to explore and identify species of L. erysimi parasitoid in highland areas of South Sumatra, and to determine potency of the parasitoids to parasitize L. erysimi in laboratory. The highest parasitism level of L. erysimi (72.40%) was found on 200 aphids which reared on B. juncea. While, the second highest parasitism level (65.67%) was found on N. indicum. The number of mummies found on N. indicum was less than on B. juncea. Of all observations, every treatment on every tested plant showed that female D. rapae emerged more than male D. rapae (female bias). The two parasitoids species that parasitized L. erysimi were Diaeretiella rapae and Aphidius sp. Parasitisation at several location in South Sumatera was highly diverse. D. rapae was the most abundant parasitoid species on several high lands at South Sumatera.
EFEKTIVITAS SATELIT RNA YANG BERASOSIASI DENGAN CUCUMBER MOSAIC VIRUS (CARNA-5) UNTUK MENGENDALIKAN PENYAKIT VIRUS PADA TANAMAN TOMAT
Authors: Akin Hasriadi Mat , Nurdin Muhammad , Simamora Patrisius Binsar , Sitorus Marlaba 
Published: January 2021

Two strains of CMV associated satellite RNA (CARNA 5.1 and CARNA 5.2) were evaluated to control severe strain of Cucumber mosaic virus (CMV-G), Tobacco mosaic virus (TMV), and Potato virus Y (PVY) on tomato plants. Tomato plants were mechanically inoculated with CARNA 5.1 and CARNA 5.2 to protect the plants from super infection of CMV-G, TMV, and PVY. The result revealed that inoculation of CARNA 5.1 and CARNA 5.2 to tomato plants effectively controlled the plants from CMV-G super infection. The effectiveness of CARNA 5.1 and CARNA 5.2 to unrelated virus, TMV and PVY, was evaluated in this experiment. The result showed that CARNA 5.1 and CARNA 5.2 inhibited TMV and PVY infection. CMV-G super infection on protected tomato plants showed mild disease symptoms, significant redution of plant growth, height, and yield; however, nonprotected plants showed severe disease symptoms and significant inhibition of plant growth and tomato yield.
KEEFEKTIFAN TIGA JENIS INSEKTISIDA NABATI TERHADAP KUTU PUTIH PEPAYA PARACOCCUS MARGINATUS DAN KEAMANANNYA TERHADAP LARVA KUMBANG PREDATOR CURINUS COERULEUS
Authors: Sifa Ahmad , Prijono Djoko , Rauf Aunu 
Published: January 2021

Effectiveness of three botanical insecticides against the papaya mealybug Paracoccus marginatus and their safety to the predatory Curinus coeruleus larvae. Preparations of Tephrosia vogelii (Tv) leaf extract (0.5% and 1% w/v), Annona squamosa (As) seed extract (0.5% and 1%), and Cinnamomum multiforum (Cm) leaf essential oil (1% and 2%), and their mixtures (Mix-1: Tv 0.25% + As 0.25% + Cm 0.5%; Mix-2: Tv 0.5% + As 0.5% + Cm 1%) were tested for their effectiveness on third-instar nymphs of Paracoccus marginatus by spraying the test materials on undetached papaya leaves and by direct spraying on the test insects using Potter spray tower. Tv extract was also applied on the test insects placed on undetached papaya leaves. The safety test was done by direct spraying of the test materials on the predatory Curinus coeruleus larvae using Potter spray tower. Tv and As extracts at a concentration of 1% each are potential to be used for the control of P. marginatus. Spraying of T. vogelii extract on the test P. marginatus nymphs placed on papaya leaves was more effective than spraying of the test materials on papaya leaves or direct spraying on the test insects only. The treatment with Cm essential oil required twice the concentration of Tv and As extracts to obtain the same level of effectiveness. The treatment with Mix-2 caused lower P. marginatus mortality than the sum of mortality caused by its components applied separately. Nonetheless, the three botanical insecticides and their mixtures were safe to C. coeruleus larvae. On the other hand, although the synthetic insecticide imidacloprid (neonicotinoid), included in the study for comparison, was effective against P. marginatus, it was also toxic to the predatory C. coeruleus larvae so its use should be avoided or limited.
VIRULENSI BERBAGAI ISOLAT JAMUR ENTOMOPATOGEN METARHIZIUM SPP. TERHADAP HAMA PENGGEREK BUAH KAKAO CONOPOMORPHA CRAMERELLA SNELL. (LEPIDOPTERA: GRACILLARIIDAE)
Authors: Trizelia Trizelia , Nurbailis Nurbailis , Ernawati Dina 
Published: January 2021

Virulence of various Metarhizium spp. (Deuteromycotina: Hyphomycetes) isolates on cocoa pod borrer pest, Conopomorpha cramerella Snell. (Lepidoptera: Gracillariidae). In Indonesia, Conopomorpha cramerella Snell. (Lepidoptera : Gracillariidae) is a serious pest of cocoa. Entomopathogens such as Metarhizium spp. (Deuteromycotina: Hyphomycetes) can be used to control this pest as an alternative to chemical insecticides. The purpose of this research was to study the virulence of isolates of Metarhizium spp. to pupae of C. cramerella. Nine isolates of Metarhizium spp each with 107 conidia/ml rate were used in the experiment. Pupal mortality was recorded daily. The results showed that isolate MetApCi from chili rhizosphere had the highest virulence causing 96.67% mortality of C. cramerella pupae and with an LT50 of 3.04 days.
SKRINING DAN IDENTIFIKASI ISOLAT BAKTERI ENDOFIT UNTUK MENGENDALIKAN PENYAKIT HAWAR DAUN BAKTERI PADA BAWANG MERAH
Authors: Resti Zurai , Habazar Trimurti , Putra Deddi Prima , Nasrun Nasrun 
Published: January 2021

Screening and identification of endophytic bacteria to control bacterial leaf blight disease on Shallot. The experiment was conducted in Laboratory and Green House, from January to June 2012. Laboratory experiment consisted of three steps: (1) isolation of endophytic bacteria from healthy onion roots, (2)In planta /screening of endophytic isolates capable of reducing bacterial leaf blight disease, and (3) molecular identification of potential endophytic isolates. Treatments of in planta test were arranged in Completely Randomized Design. Collected isolates were tested for their capability in controlling bacterial leaf blight disease on shallot. The variables observed were disease incidence, disease severity, and shallot yield. The results showed that out of 82 isolates successfully isolated, 56 isolates (68.29%) were Gram positive, and 26 isolate (31.71%) were Gram negative. All isolates were HR negative and pathogenicity negative. Six endophytic isolates showed better performance in inducing resistance and increasing onion yield. Based on 16S rRNA sequence the six isolates were Bacillus cereus strain P14 , Bacillus cereus strain Se07, Bacillus sp H1, Bacillus sp SJ1 and Serratia marcescens strain PPM4.
PENGARUH APLIKASI PSEUDOMONAS FLUORESCENS P60 TERHADAP MUTU PATOLOGIS, MUTU FISIOLOGIS, DAN PERTUMBUHAN BIBIT PADI IR 64
Authors: Navitasari Lisa , Soesanto Loekas , Rahayu Ahadiyat Yugi 
Published: January 2021

Effect of Pseudomonas fluorescens P60 on pathological and physiological quality and growth of rice IR 64 seedlings. The research objectives were (1) detection and identification of seed-borne pathogens of IR 64 rice, (2) testing Pseudomonas fluorescents P60 in inhibiting the in vitro growth of seed-borne pathogens colonies, (3) testing P. fluorescents P60 for pathological and physiological seed quality, and (4) testing P. fluorescents P60 on the growth of seedlings in the greenhouse. The results showed that some seed-borne pathogens can be found both on farmers’ IR 64 rice and factory’s; they were Aspergillus flavus, Alternaria padwickii, Pseudomonas glumae, and P. syringae. Application of P. flourescens P60 was able to inhibit the in vitrogrowth of colonies of all seed-borne pathogens, except P. syringae. Related to pathological quality, the effect of P. flourescens P60 on percentage of seed-borne pathogens attack did not significantly different from that of benomil but smaller than distilled water. On the physiological quality of seeds, treatment of P. flourescens P60 has the same effect with benomil and distilled water, with germination rate was more than 80%. In the greenhouse study,treatment of seed immersion time in P. flourescens P60 suspension showed that the effect of immersion time as long as15 minutes and 25 minutes on seedling height, root length, and seedling dry weightdid not significantly different. were. However, 25 minutes immersion time resulted in fresh seedling weight and root dry weight higher than that of 15 minutes immersion time.
DAMPAK MANAJEMEN PERUBAHAN LINGKUNGAN KERJA MASA PANDEMI COVID-19 TERHADAP PEGAWAI PT TELKOM INDONESIA Tbk DIVREG 3 JAWA BARAT
Authors: Ismawanti Resty 
Published: January 2021

WHO (World Health Organization atau Badan Kesehatan Dunia) secara resmi mendeklarasikan virus corona (COVID-19) sebagai pandemi pada tanggal 9 Maret 2020. Tujuan penelitian ini untuk mengetahui dan menganalisis dampak manajemen perubahan lingkungan kerja masa pandemi COVID-19 terhadap PEGAWAI PT TELKOM INDONESIA Tbk DIVREG 3 Jawa Barat. Dampak manajemen perubahan lingkungan kerja masa pandemi COVID-19 terhadap PEGAWAI PT TELKOM INDONESIA Tbk DIVREG 3 Jawa Barat yaitu manajemen membutuhkan sistem yang dapat membantu seluruh tim berkoordinasi guna memastikan operasional bisa berjalan dengan baik. Bagi PT TELKOM INDONESIA Tbk DIVREG 3 Jawa Barat yang menerapkan work from office (WFO), perusahaan pun disarankan untuk menyiapkan protokol kesehatan untuk melindungi karyawan dari bahaya Covid-19, mulai dari melakukan deteksi suhu, penyemprotan disinfektan, hingga penyediaan masker bagi karyawan.
The Difference in Average of Maternal Serum Hypoxia-Inducible Factors-1Î± Levels between Early Onset and Late-Onset Severe Preeclampsia
Authors: Perdana David , Defrin Defrin , Firdawati Firdawati 
Published: January 2021

The purpose of this study is to know the difference average of maternal serum levels of HIF-1Î± between early-onset and late-onset severe preeclampsia. This study used a cross sectional comparative study design that conducted in Februari 2020 - Agustus 2020 in the SMF / Obstetrics and Gynecology department of RSUP dr. M. Djamil Padang, RSUD Achmad Mochtar, RSUD Pariaman, RSUD M Zein Painan. We used consecutive sampling method which consists of 60 pregnant women who fulfill the inclusion and exclusion criteria. They were divided into two groups early-onset severe preeclampsia and late-onset severe preeclampsia. HIF-1Î± tests were done using ELISA method. The average of maternal serum levels of HIF-1Î± in late-onset severe preeclampsia is found to be the highest when compared to the early-onset severe preeclampsia, 1,37 Â± 1,08 ng/ml vs 0,69 Â± 0,11 ng/ml. This difference is significant with the Mann-whitney non parametrical statistical test (p <0.05). There is a significant difference average of maternal serum levels of HIF-1Î± between early-onset and late-onset severe preeclampsiaKeywords: early onset severe preeclampsia, late onset preeclampsia late onset, maternal serum levels ofÂ HIF-1Î±