bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bisbenzylisoquinoline Alkaloids of Cissampelos Sympodialis With in Vitro Antiviral Activity Against Zika Virus
Authors: da Silva Poliana Gomes , Fonseca Aventino H. , Ribeiro Malu P. , Silva Taizia D. , Grael Cristiane F. F. , Pena Lindomar J. , Silva Tania M. S. , Oliveira Eduardo de Jesus 
Published: September 2021

In search of new antiviral compounds against Zika virus we conducted a bioassay-guided fractionation of bisbenzyilisoquinoline alkaloids isolated from Cissampelos sympodialis (Menispermaceae), a medicinal plant species endemic to Brazil. Six subfractions were obtained from a tertiary alkaloidal fraction of the rhizomes (TAFrz) using preparative high-performance liquid chromatography. All the subfractions were tested against Zika virus-infected Vero cells as the cellular model to evaluate cytotoxicity and antiviral effective concentrations. The results showed that three of the six TAFrz subfractions tested were active. The most active ones were the subfraction 6 (that consisted of the alkaloids methylwarifteine and warifteine present as a mixture at a ratio of 8.8:1.2 respectively) and the subfraction 5, that was later identified as warifteine, the major tertiary alkaloid of this species. Warifteine was able to significantly reduce virus titer in Zika virus-infected Vero cells with an IC50 of 2.2 μg/ml and this effect was selective (selectivity index, SI = 68.3). Subfraction 6 had an IC50 = 3.5 μg/ml and was more cytotoxic than pure warifteine, with SI = 6.14. Fraction 5 and fraction 6 were more potent in decreasing the viral titer of Zika virus-infected Vero cells than 6-methylmercaptopurine riboside (IC50 = 24.5 μg/ml and SI = 11.9), a mercaptopurine riboside with ZIKV antiviral activity used as a positive control. Our data demonstrate that alkaloids of the bisbenzylisoquinoline type may be explored as new antiviral agents or as an useful pharmacophore for investigating ZIKV antiviral activity.
The Degree of Linear Polarization for Suspended Particle Fields from Diverse Natural Waters
Authors: Zhai Siyao , Twardowski Michael 
Published: September 2021

The Degree of Linear Polarization (DoLP) for unperturbed particle fields in waters from six diverse regions around the globe was measured with the custom Multi-Angle Scattering Optical Tool (MASCOT). DoLP here is defined as the ratio of two elements of Mueller scattering matrix, i.e., -M12/M11. Field sites covered inland waters, coastal oceans and open oceans, including both ocean color Case I and II water types. The angular shape of the measured particulate DoLP was analyzed in detail for each field site and for the ensemble average. Three parameters used to quantitatively characterize DoLP shape were the symmetry with respect to 90°, peak magnitude, and peak angle of measured DoLP angular curve. Vertical profiles of particulate DoLP were analyzed with maximum recorded depth of 111 m. Converse to Rayleigh scatterers, we found measured particulate DoLPs were not symmetric with respect to 90°. On average, DoLP peaks were shifted slightly toward larger angles, with most falling between estimated values of 90° and 95°. All particulate DoLP peak magnitudes generally varied within [0.6, 0.9]. Lorenz-Mie (homogeneous sphere) light scattering theory was used to construct a new inversion for bulk particulate refractive index from a lookup table based on DoLP and spectral attenuation measurements. We compared the Mie-DoLP-based particulate refractive index retrieval with the backscattering-based model from (Twardowski et al., J. Geophys. Res., 2001, 106(C7), 14,129–14,142). Particulate refractive index retrieved with the two models were in some cases comparable. At two of the six field sites we saw good agreement between the two models, whereas at another two field sites we observed large discrepancies between the two models. Further investigation on the choice of the modeled particle shapes and compositions may improve this retrieval approach. Results are compatible with previous studies on DoLPs in natural waters and comprehensive observations are provided on the particulate DoLP angular shape, vertical profile and global distributions that are important for future vector radiative transfer simulations. This study is relevant to future PACE polarimeters and associated remote retrieval of oceanic particle composition using polarimetry.
TERAPI TERTAWA MENURUNKAN DEPRESI PADA PERAWATAN LANJUT USIA : A LITERATUR REVIEW
Authors: Risnah Risnah , Jumasing Jumasing , Nur Insani Rina , Fahril Anwar Muh , Irwan Muhammad 
Published: September 2021

Depresi merupakan penyakit yang umum di seluruh dunia dan lebih dari 300 juta orang terkena dampaknya. Metode penatalaksanaan Depresi pada lansia yang telah diteliti dan diuji keberhasilannya baik di Indonesia maupun dunia. Salah satu tatalaksana non farmakologi yang telah di uji keberhasilannya adalah dengan menggunakan terapi tertawa. Tertawa merupakan salah satu terapi komplementer yang digunakan dalam pengobatan berbagai penyakit. Terapi tertawa adalah tipe khusus dari psikoterapi dalam bentuk distraksi untuk mengurangi tekanan permasalahan yang mengakibatkan depresi. Tujuan artikel ini adalah untuk mereview literature tentang pengaruh terapi tertawa terhadap penurunan tingkat depresi pada lansia. Metode penelitian ini adalah studi literature dengan pencarian literatur review ini menggunakan database Science Direct, PubMed dan Goggle Scholar dengan menggunakan keywords: “Terapi Tertawa Depresi Lansia”. Hasil pencarian artikel menemukan sebanyak 1205 artikel dalam jurnal nasional dan internasional dalam rentang tahun 2017 sampai 2020. Artikel tersebut diseleksi dan yang memenuhi kriteria inklusi dan eksklusi adalah sebanyak 8 artikel. Hasil dari 8 jurnal tersebut, 7 penelitian menunjukkan bahwa ada perubahan efek yang signifikan dalam penurunan gejala depresi pada lansia setelah dilakukan beberapa jenis terapi diantaranya Laughter Therapy dan Humour Therapy, mempunyai peranan yang sangat penting dalam petatalaksanaan non-farmakologi atau sebagai manajemen depresi pada lansia. Terapi tertawa ini menunjukkan sebagai salah satu metode yang efektif dalam menurunkan tingkat depresi pada lansia. Tinjauan literatur review ini mendapatkan hasil bahwa pemberian terapi tertawa efektif dalam menurunkan tingkat depresi pada lansia.
Kata Kunci: terapi tertawa, depresi, lansia
Growth and Yield of Okra Using Bio-Stimulant of Golden Apple Snails Extracts and Fertilizer on Ultisol
Authors: Fatma Nurshanti Dora , Defrian Defrian , Novriani Novriani 
Published: September 2021

Cultivation of okra on ultisol soils having poor physical, chemical and biological soil properties can be improved by administering a bio-stimulant extract of golden snails and combined with NPK fertilizer. This research objective was to study a combination of bio-stimulant treatment of golden apple snail extract and NPK fertilizer dosage in increasing the growth and yield of okra on ultisol soil. This study used a factorial completely randomized design with two factors. The first factor was Bio-stimulant golden apple snails extract consisting of 4 treatment, and the second factor was levels of NPK fertilizer consisting of 3 treatment. Fertilizers had a significant effect on increasing overall plant growth. The bio-stimulant extracts of golden apple snails contain organic materials that can improve physical properties (increasing aggregation, moisture retention, soil hydraulic conductivity), chemical (increasing soil organic carbon content) and biology (increasing soil microbial biomass). The nutrient content in NPK fertilizers can increase nutrients; the availability of nutrients in the soil is balanced and can be absorbed by plants so that the photosynthesis process in plants can run well and increase on growth and yield of okra. The combination of bio-stimulant extract of golden apple snails of 20 mL/L water and NPK fertilizer of 150 kg/ha (1 g/polybag) had the highest resulted in the average value of growth and yield of okra on the ultisol soils.
Impact of COVID-19 Pandemic on Global Healthcare Systems and the role of a new era of global collaborations
Authors: Jain Parth 
Published: September 2021

The Covid-19 pandemic has changed the world, socially, economically and politically. There have been many positives in global scientific information flow, collaboration, speed of translation of research, technological innovation and its diffusion has been phenomenal. However the cost to human lives and livelihood has also been catastrophic.
In the post-pandemic world, the ambition to provide a well-resourced and universal health infrastructure to populations has become a challenge even for wealthy nation-states. The access to routine and elective healthcare has become severely compromised. In poorer nations, this has affected basic healthcare needs particularly for children, women and those on or below the poverty line.
Yet health is a fundamental human right, one that is guaranteed by the treatise on ‘Declaration of Health for All’ to which most countries are signatories. However, could the impact of this pandemic be mitigated by global health initiatives and collaboration? In this context, it is pertinent to analyse the existing global health framework and conventions to identify how we may prepare for future challenges.
Updated Ephemeris and Evidence for a Period Change in the Eclipsing Novalike Variable 1RXS J064434.5+334451
Authors: Shafter A. W. , Bautista Vladimir 
Published: September 2021

Abstract
We report seven new eclipse timings for the novalike variable 1RXS J064434.5+334451. An analysis of our data, along with all previously available timings (36 published and 16 unpublished), yields a best-fitting linear ephemeris of BJDecl = 2,453,403.7611(2) + 0.269,374,43(2)E. We find a somewhat improved fit with a quadratic ephemeris given by: BJDecl = 2,453,403.7598 + 0.269,374,87 E − 2.0 × 10−11
E
2, which suggests that the orbital period may be decreasing at a rate given by

P

˙

≃
−
1.5
×

10

−
10

.
La crèche familiale thérapeutique : un dispositif pour les fratries puînées d'enfants autistes
Authors: Klein Anaelle , Breil Fleur , Durieux Marie-José , Rappaport Clémentine 
Published: September 2021

Il s’agit d’exposer notre cheminement de pensées et la naissance de nos interrogations autour de ces situations d’enfants autistes où la question d’une surveillance, voire d’une prise en charge des frères et sœurs puînés s’est posée. Nous présentons notre cas princeps, celui d’un garçon de 30 mois chez qui nous avons diagnostiqué un autisme infantile. Les éléments biographiques, l’histoire développementale et l’anamnèse des troubles ont été principalement recueillis grâce au récit de la mère. Trois consultations pédopsychiatriques et deux séances de psychomotricité ont permis l’élaboration du diagnostic. Durant le temps d’observation des troubles de ce jeune garçon, sa petite sœur de 4 mois a progressivement présenté des signes de souffrance qui nous ont paru inquiétants. La question de la prise en charge de celle-ci s’est donc posée. Nous soulevons la problématique du retentissement de l’autisme sur les fratries puînées à travers une étude des risques génétique, psychiatrique et psychologique. Le repérage précoce des signes prémorbides chez ces bébés considérés comme « à risque autistique » est important à connaître dans un but de prévention. Nous décrivons le dispositif de crèche familiale thérapeutique, développé au sein de la consultation pédopsychiatrique des 0-3 ans de l’hôpital d’Aulnay-sous-Bois, afin que les frères et sœurs d’enfants autistes aient des temps de soins précoces adaptés.
De l'irréparable
Authors: Lefebvre Danielle , Stéphanoff Marina 
Published: September 2021

Notre société fait la part belle à la notion de séparation tellement la souffrance d’autrui nous apparaît comme insupportable et, ce faisant, transforme tout sujet ayant subi un acte plus ou moins barbare de la part d’un adulte, en victime pure. Or, est-ce le bon chemin pour faire qu’il n’y ait pas répétition et que l’enfant, de position de sujet souffrant d’actes irréparables, puisse vivre sa vie d’adulte autrement qu’en « ancienne victime » réclamant sans cesse réparation. Quelle réparation ? À travers une courte vignette clinique, les auteurs montrent ainsi comment reconnaître l’irréparable, c’est aussi penser la séparation comme un acte thérapeutique qui permettra de différencier les souffrances et de les accueillir comme telles. C’est faire barrage à la répétition.
Vivre et accompagner les séparations, l'accompagnement en accueil familial
Authors: Martinez Anne-Marie 
Published: September 2021

L’auteur présente les grands traits de la procédure de placement familial d’un mineur, mais surtout insiste sur la notion de contrat et la procédure d’accompagnement et de préparation indispensable pour mener à bien cette opération douloureuse. Un enfant qui arrive est un enfant qui part : cela signifie qu’il faut tenir compte de la douleur de la séparation d’un enfant vis-à-vis de ses parents, même maltraitants, mêmes auteurs de violence ou de négligence. L’enfant accueilli est un hôte de passage ; il est important d’avoir cette notion de temporalité dans la procédure, il ne s’agit pas d’un placement définitif. Et le départ vers sa famille d’origine ou dans la vie d’adulte mérite aussi un rite de départ, une fête. Ainsi, le mineur placé pourra vivre au mieux ce moment.
Adolescence : Crise !
Authors: Agraimbah Aicha , Carda Priscille , Couppey Émeline 
Published: September 2021

« Je me rappelle de cette crise qu’on appelle tous « crise d’adolescence » qui a	fait de moi un être monstrueux durant 3 années. Je me rappelle des nuits passées	hors de la maison où je sortais en cachette et prétextais, quelques heures après,	être chez une copine… »	La crise d’adolescence n’est pas un passage obligé ou un rite. La relation	qu’entretient la famille avec le jeune avec un refus pour certains parents de le	voir s’émanciper est un des facteurs de cette crise.
Development of an operational excellence framework for organisational performance improvement in the Sudanese aviation industry
Authors: Osman Mohamed Ibrahim , Mohammad Roslina , Yusof Sha'ri , Chelliapan Shreeshivadasan 
Published: September 2021

Purpose: The purpose of this study is to investigate the Critical Success Factors (CSFs) for successful implementation of Operational Excellence (OE) by the organisations in the Sudanese aviation industry, as well as to determine the resulted impacts in the improved organisational performance and competitive advantage, and to quantify the benefits.Design/methodology/approach: The Critical Success Factors (CSFs) of OE were provided and dissected to reveal its integrated components and their importance levels. These factors include leadership, people management, continuous improvement, operational strategy, and asset optimisation. Also, the impacts (outcomes) further categorised in the four financial results, quality of products or services, efficiency, and satisfaction groups were presented, while the weight of each outcome was highlighted.Findings: With the OE's conceptual framework, the critical success factors to achieve OE were identified. Hence, from the five main factors, the expert panel members suggested the leadership factor to be the most important to achieve OE in the Sudanese aviation industry. Ranking of the five critical success factors and the forty sub factors provided a better understanding of the Sudan situation, specifically concerning the effective implementation of OE philosophy.Research limitations/implications: The findings of the sub-factors reported in this study were not enough. As a result, the future studies must focus on the detailed descriptions of sub-factors that are related to each of the critical factor identified. Practical implications: Efficiency in the organisations is generated and enhanced when the organisations become efficient in reducing the waste of time, raw materials, unnecessary processing, in addition to the energy used in transportation, storing, and operating plant. Besides, the state of effectiveness is achieved when the organisation achieves its long-term goals through increased customer satisfaction and is able to prove its reason for being. OE is critical as it assures both the efficiency and effectiveness of organisationsOriginality/value: The past research activities have relatively over-emphasised in the unilateral "result-driven" perspective of OE that corresponds with the limited concern for enablers, the critical forms and focus of OE. Thus, this issue is a shortcoming that this paper attempts to address.
Du contrôle de l’innovation à la créativité : vers un cadre intégrateur
Authors: Bollinger Sophie , Burger-Helmchen Thierry 
Published: September 2021

Les travaux sur les différents déterminants du contrôle managérial de l’innovation se sont multipliés ces dernières années. Ces recherches se caractérisent par une grande variété d’innovations étudiées et par la diversité des outils de contrôle employés par les organisations. Dans cet article, nous catégorisons les principaux travaux sur le contrôle de l’innovation en fonction de trois dimensions : type de management, forme de contrôle et mesure de performance. Cette analyse nous permet de clarifier certaines tensions, de la dualité contrôle-créativité, qui découlent du contrôle de l’innovation ou qui sont spécifiques au champ de la créativité.Classification JEL : M10, M4, O32, O39.
Entrepreneuriat et créativité : du détournement à la création de valeur
Authors: Gaffard Jean-Luc 
Published: September 2021

De la capacité de l’entrepreneur à concevoir une organisation apte à créer des canaux d’information suffisamment robustes dépendent la nature des innovations effectuées, la façon dont sont exploitées les connaissances scientifiques et techniques, l’usage qui est fait de l’esprit créatif. C’est à cette aune qu’il convient de juger du comportement entrepreneurial, des rythmes imposés par la finance, de la façon dont sont allouées les ressources humaines. La réalité de la créativité réside dans le choix opéré entre recherche de rentes et innovations productives, entre une finance impatiente et une finance patiente, entre flexibilité et rigidité sur les marchés de travail. C’est un choix d’ordre organisationnel et institutionnel.Classification JEL : D21, D23, D47, J53, L26.
Leaked Mitochondrial C1QBP Inhibits Activation of the DNA Sensor cGAS
Authors: Song Kun , Wu Yakun , Fu Bishi , Wang Lingyan , Hao Wenzhuo , Hua Fang , Sun Yiwen , Dorf Martin E , Li Shitao 
Published: September 2021

Abstract
Cytosolic DNA from pathogens activates the DNA sensor cyclic GMP–AMP (cGAMP) synthase (cGAS) that produces the second messenger, cGAMP. cGAMP triggers a signal cascade leading to type I IFN expression. Host DNA is normally restricted in the cellular compartments of the nucleus and mitochondria. Recent studies have shown that DNA virus infection triggers mitochondrial stress, leading to the release of mitochondrial DNA to the cytosol and activation of cGAS; however, the regulatory mechanism of mitochondrial DNA-mediated cGAS activation is not well elucidated. In this study, we analyzed cGAS protein interactome in mouse RAW264.7 macrophages and found that cGAS interacted with C1QBP. C1QBP predominantly localized in the mitochondria and leaked into the cytosol during DNA virus infection. The leaked C1QBP bound the NTase domain of cGAS and inhibited cGAS enzymatic activity in cells and in vitro. Overexpression of the cytosolic form of C1QBP inhibited cytosolic DNA-elicited innate immune responses and promoted HSV-1 infection. By contrast, deficiency of C1QBP led to the elevated innate immune responses and impaired HSV-1 infection. Taken together, our study suggests that C1QBP is a novel cGAS inhibitor hidden in the mitochondria.
Importance of Determining and Establishing Latex Allergy in Orthodontic Patients
Authors: Umar Dilshad , Alrashidi Hanan Ali , Alnazer Heba Abdulaziz , Arnous Waod Ahmed 
Published: September 2021

Introduction:
The current study was commended with the aim of assessing the incidence of latex allergy in orthodontic patients.

Materials and Methods:
Silver-coloured orthodontic elastomeric ligatures (modular) from six different manufacturers were selected for the cytotoxicity study, being one of natural latex, two of latex-free and three containing polyurethane. The samples were divided into 6 groups of 15 elastics each. The cytotoxicity of these orthodontic elastics was determined through the dye-uptake technique, which is based on the neutral red absorption by living cells. Different periods of time were considered: 1, 2, 3, 7 and 28 days.

Results:
Among all the respondents to the survey, 7.5% showed positive change after wearing elastics. Most of the positive changes were seen in females

Conclusion:
Safe orthodontics practice is dependent upon recognising patients with allergy along with awareness of etiologic materials.
Awareness and Commitment Towards Precautionary Measures Against COVID-19 Among Residents of Majmaah City, Saudi Arabia
Authors: Ahmad Mohammad Shakil , Shaik Riyaz Ahamed , Ahmad Ritu Kumar , Almutairi Abdulaziz Bader , Alghuyaythat Waleed Khalid , Almutairi Shaden Bader 
Published: September 2021

Introduction:
The continued explosive spread of severe acute respiratory syndrome coronavirus-2 worldwide is a crucial problem for all countries. Even though it is becoming increasingly difficult to stop the spread of the virus according to the World Health Organisation, countries need to enforce strict measures to minimise its effects. This study attempts to assess the awareness and compliance of the local population for following the precautionary measures against.

Materials and Methods:
A cross-sectional study was carried out at different districts of Majmaah city, Saudi Arabia. A cross-sectional survey study was carried out at different districts of Majmaah city, Saudi Arabia, and 502 individual's respondents were included in the study. Data were collected using a self-↱administered questionnaire for noting compliance towards protective measures. All participants were informed about the nature of the study and given an informed consent form. Data were collected and analysed using SPSS@ 25 (SPSS Version 25.0. Armonk, Newyork: IBM Corp). Categorical variables were expressed as frequencies and percentages. t-test was applied to compare mean scores.

Results:
There were 502 people who participated in this study, among them 260 (51.8%) were males and 242 (48.2%) females. This study highlighted that the population awareness was good and residents showed strong commitment towards coronavirus disease-2019 (COVID-19) precautionary measures. The overall mean scores for awareness and commitment levels were 6.68 ± 1.04 and 4.00 ± 1.13.

Conclusions:
Most participants in the study had a positive perception of COVID-19 prevention and control. Residents of Saudi Arabia responded well to the threat imposed by COVID-19 and are following their government and health regulatory body's instructions. It is therefore suggested that this would also be a valuable resource for policymakers of Saudi Arabia