bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatoprotector Effect of Coconut Water (Cocos nucifera L.) and Folic Acid to the Liver Histopathological Desccription of Pregnant Wistar Female Rats (Rattus norvegicus) Induced by Carbamate
Authors: Ridho Muhammad Rosyid , Prasetyo Aris , Hairrudin Hairrudin 
Published: March 2021

Abstract
Carbamate is an insecticide with a working mechanism that inhibits the enzyme acetylcholineestrase (AChE). Obstacles to AChE will cause the formation of excessive free radicals in the body causing oxidative stress and causing lipid peroxidation in body cells, including hepatocyte cells in the liver. Pregnant women have a change in detoxification activity in the liver due to exposure to xenobiotic substances during pregnancy causing a decrease in cytochrome P450 1A2 (CYP1A2) which will cause an increase in free radicals and can damage liver cells. Coconut water contains antioxidants that can neutralize free radicals in the body. While folic acid can encourage improvement in morphology of liver cells. The purpose of this study was to determine the hepatoprotector effect of coconut water and folic acid on the histopathology of the liver of pregnant female wistar rats induced by carbamate. The design of this study is true experimental with a post test only control group design. The sampling method used is simple random sampling. The number of samples in this study were 28 rats divided into 4 groups K (aquades), P1 (carbamate), P2 (carbamate and coconut water), and P3 (carbamate and folic acid). At the end of the study rat liver was taken to then become histological preparations. The One Way ANOVA test results showed a significant difference between groups compared (p <0.05). Post hoc LSD test results showed that group P1 had damaged liver histopathology, there were significant differences with group K and P3 (p <0.05), but there were no significant differences when compared with group P2 (p = 0.826). Meanwhile, the P3 group had significant differences when compared with all groups (p <0.05). The conclusion of this study is that giving coconut water cannot prevent liver damage due to carbamate induction, while folic acid has been shown to prevent liver damage due to carbamate induction, from liver histopathology.
Keywords: carbamate, coconut water, folic acid, liver histopathology
Potentials of Grinting Grass (Cynodon dactylon l.) For Biopesticides On Sitophylus Zeamais Motsch Mortality
Authors: Yasi Ratna Mustika , Lestari Riska Fita 
Published: March 2021

Corn is one of the cereals that has strategic and economic value and has the opportunity to be developed. The attack of the Sitophilus Zeamais Motsch species becomes one of the obstacles in the process of storing corn. This study aims to develop the potential of plant biopesticides from grinting grass to control the warehouse pests of Sitophilus Zeamais Motsch. This research is a laboratory based experimental study. The independent variables in this study were the gram weight of grinting grass extract and the number of Sitophilus Zeamais Motsch pests. The dependent variable in this study was the mortality of Sitophilus Zeamais Motsch. Grinting grass extract is obtained using maceration method. Qualitative and quantitative tests were carried out to test the active compound content of grinting grass. Vegetable biopesticide toxicity tests were carried out using a completely randomized design. The results showed that variations in the weight of grinting grass affect the content of chemical compounds present in the grass. Based on UV-Vis and FTIR spectra, the content of polyphenols, alkaloids, flavonoids, terpenoids, steroids, and saponins contains 20 gr / 100 mL, there are flavonoids as much, 2.38 mg / mL, saponins as 2.04 mg / mL, alkaloids as much as 1.79 mg / mL, polyphenols 3.15 mg / mL, steroids as much as 2.24 mg / mL and terpenoids as much as 3.15 mg / mL. Based on qualitative tests the active compound is evidenced by changes in color and deposition. While based on pest mortality tests, it was found that almost 50 percent of grinting grass extract can kill corn pests within a period of 7 days of observation with an extract concentration of 800 ppm.
Key words: Biopesticides, Grinting Grass, Uv-Vis
Comparison Of The Effect Of Vitamin E And Rosmarinic Acid On Expression Of P65 NF-KB Subunit In Diabetes Rat
Authors: Prima Wahyu , Samsu Nur , Khotimah Husnul 
Published: March 2021

One of the causes of diabetic nephropathy (ND) that have important role is the increase of free radicals due to high levels of glucose which causes oxidative stress. Oxidative stress activates Angiotensin II and the transcription factor of Nuclear Factor kappa B (NFKb). Prevention and slowing down of ND progression is by using antioxidants. The example of antioxidants are Vitamin E and Rosmarinic Acid (RA). Vitamin E is a conventional antioxidant while RA is a potent antioxidant that also has anti-inflammatory effects. This laboratory experimental study aimed to compare the effects of Vitamin E and RA on the expression of NFKb p-65 in glomelurus of type 2 diabetes rats. NFKb expression of p-65 of positive control increased significantly compared to negative controls (p <0.001), Vitamin E and RA were able to reduce NFKb expression compared to positive controls (p = 0.022 and p = 0.001). respectively there was no significant difference between NFKb expression in the Vitamin E group and Rosmarinic acid but RA decreased better than Vitamin E. It can be concluded that AR had a better effect compared to Vitamin E on the decrease in NFKb p-65 expression in glomelurus type 2 diabetes rats.
Keyword: Diabetic nephropathy, Nuclear Factor kappa B (NF-Kb), Rosmarinic Acid, Vitamin E
The Relationship Duration of Sitting and Work Posture Risk with LBP in Library Staff University of Jember
Authors: Cahyani Diana Eki , Hasan Muhammad , Rumastika Nindya Shinta 
Published: March 2021

Low back pain (LBP) is one of the occupational diseases caused by non-ergonomic conditions. The global point prevalence of LBP which limits activity in 2015 was 7.3%. This figure shows that in one time there were 540 million people who experienced LBP. As many as 90% of cases of low back pain are not caused by organic abnormalities but by errors in body position at work. Risk factors that have the potential to cause complaints include age, gender, Body Mass Index (BMI), smoking habits, work period, poor work posture, and standing or sitting too long. This study aims to determine the relationship between duration of sitting and risk of work posture with the level of LBP complaints in Jember University library employees. The type of research used was analytic observational with cross sectional study design. The sampling technique is done by total sampling. The research samples were University Library staff in Jember who experienced LBP complaints and in accordance with the inclusion and exclusion criteria of this study. The sample size was 22 respondents. The instruments of this study were respondent characteristics questionnaire sheets, LBP screening sheets, and Modified Quick Exposure Check (QEC) assessment sheets. Bivariate analysis using the gamma correlation test. The results of the bivariate analysis between duration of sitting and LBP complaint rates obtained p = 0.827. The results of the bivariate analysis between the risk of work posture and LBP complaints were obtained p = 0.916. The two results of the analysis indicate that there is no significant relationship between the duration of sitting and the risk of work posture with the level of LBP complaints in Jember University library employees.
Keywords: low back pain, duration of sitting, work posture, library staff
Correlation between Personal hygiene and Household Overcrowding to the Incidence of Pediculosis capitis in Sukogidri Village Jember
Authors: Nadira Warda Ayu , Sulistyaningsih Erma , Rachmawati Dwita Aryadina 
Published: March 2021

Abstract

Pediculosis capitis is an infection of human hair or scalp caused by Pediculus humanus var. capitis. This disease is classified as a neglected disease and is quite developed in developing and poor countries. Risk factors that influence the incidence of pediculosis capitis is the level of education of parents, socio-economy, personal hygiene, age, gender, and household overcrowding. The purpose of this study was to determine the correlation between personal hygiene and household overcrowding to the incidence of pediculosis capitis in Sukogidri Village Jember. This study was an observational analytic study, with a cross sectional approach carried out on 230 respondents in Sukogidri Village Jember. In this study, head lice was examined using crescent combs, filling in personal hygiene questionnaires, and measuring the area of ​​respondent’s house. The results showed the prevalence of pediculosis capitis in Sukogidri Village was 44.3% (102 respondents). The results of data analysis using the fisher test and chi-square test showed that personal hygiene and household overcrowding had a significant relationship (p <0.05) as a risk factor for the incidence of pediculosis capitis in Sukogidri Village Jember.
Keyword : personal hygiene, household overcrowding, pediculosis capitis
Assessing Bioenergetic Function in Response to Reactive Oxygen Species in Neural Cells
Authors: Sameti Mahyar , Castello Pablo R. , Lanoue Matthew , Karpova Tatiana , Martino Carlos F. 
Published: March 2021

In this study, we characterized the bioenergetic response of the Lund human mesencephalic (LUHMES) cell line and a mouse astrocyte cell line to oxidative stress. Extracellular hydrogen peroxide (H2O2) levels and bioenergetic response were investigated in these cell lines after exposure to paraquat (PQ), a redox cycling compound that causes oxidative stress in cells. We used extracellular flux analysis to measure mitochondrial function in adherent astrocytes and LUHMES cells. Extracellular H2O2 was measured fluorometrically. H2O2 levels increased in both cell lines after exposure to 5 µM PQ for 18 h; however, the extent of H2O2 increase with astrocytes was significantly lower than that with LUHMES cells (33% vs. 67%). Measurements of basal mitochondrial respiration showed that PQ almost completely eliminated oxygen consumption rate (OCR) in astrocytes and significantly reduced it in LUHMES cells. Notably, OCR in LUHMES cells was higher than that in astrocytes, indicating that neuronal cells maintain higher oxidative metabolism than glial cells, which is also consistent with higher energy demands of the neuronal cells. Moreover, LUHMES cells exhibited a higher amount of adenosine triphosphate (ATP) being produced by oxidative phosphorylation than by glycolysis. In contrast, astrocytes demonstrated a higher glycolytic capacity and glycolytic reserve than LUHMES cells and higher ATP production rate by glycolysis than its production by mitochondrial oxidative metabolism. Collectively, this study showed the differential bioenergetic responses between astrocytes and LUHMES cells in responding to oxidative stress and the findings may provide insights into the mitochondrial reserve capacity in neurons and astrocytes in responding to oxidative stress.
(First online: Mar 30, 2021)
DETERMINAN PENGUNGKAPAN INFORMASI INKLUSI KEUANGAN PADA BANK UMUM SYARIAH DI INDONESIA
Authors: Mubarok Ahmad Shofiy , Suprayogi Noven 
Published: March 2021

ABSTRAKPenelitian ini bertujuan untuk mengetahui pengaruh ukuran bank, reputasi, profitabilitas, aktivitas sosial terhadap pengungkapan informasi inklusi keuangan pada bank umum syariah di Indonesia periode 2015-2019 secara parsial dan simultan. Penelitian ini menggunakan metode kuantitatif dengan teknik analisis regresi data panel menggunakan alat penelitian Eviews 10. Hasil penelitan ini menunjukkan bahwa secara parsial, variabel ukuran bank, reputasi, aktivitas sosial berpengaruh positif signifikan terhadap pengungkapan informasi inklusi keuangan. sedangkan profitabilitas berpengaruh negatif signifikan terhadap pengungkapan informasi inklusi keuangan. Secara simultan, variabel ukuran bank, reputasi, profitabilitas, aktivitas sosial berpengaruh positif signifikan terhadap pengungkapan informasi inklusi keuangan pada bank umum syariah di Indonesia periode 2015-2019. Kata Kunci: Ukuran bank, reputasi, profitabilitas, aktivitas sosial, pengungkapan informasi inklusi keuangan. ABSTRACTThis study aims to determine the effect of bank size, reputation, profitability, social activity on financial inclusion information disclosure of sharia commercial banks in Indonesia from 2015 to 2019 partially and simultaneously. This study uses a quantitative method with panel data regression analysis with Eviews 10. The results of this study indicate that partially, the variables of bank size, reputation, social activity have a significant positive effect on financial inclusion information disclosure. While profitability has a significant negative effect on financial inclusion information disclosure. Simultaneously, the variables of bank size, reputation, profitability, social activity have a significant positive effect on financial inclusion information disclosure of sharia commercial banks in Indonesia from 2015 to 2019.Keywords: bank size, reputation, profitability, social activity, financial inclusion information disclosure.
Ankilozan Spondilitli Hastalarda Nöropatik Ağrının Hastalık Aktivite Skorları İle İlişkisi ve Anti-TNFα Kullanımının Etkisi
Authors: KİMYON Gezmiş , GEZİCİ Ümran , GÜMÜŞAY Meryem , KARADAĞ Mehmet , BAY Feyyaz , MELEK İsmet 
Published: March 2021

Amaç: Bu çalışmada ankilozan spondiliti olan hastalarda nöropatik ağrının hastalık aktivite indekslerine etki edip etmediği ve aynı zamanda tedavide kullanılan anti-TNFα gibi ajanların bununla ilişkili olup olmadığını araştırmayı amaçladık.
Gereç ve Yöntem: Çalışmaya modifiye New York kriterlerine göre ankilozan spondilit tanıs konan 98 hasta ve yaş ve cinsiyet uyumlu 99 sağlıklı kontrol alındı. Her iki grupta nöropatik ağrı painDETECT skorlamasına göre yapıldı. Ankilozan spondilit hastalarının hastalık aktiviteleri BASDAI (Bath Ankylosing Spondylitis Disease Activity Index), BASFI (Bath ankylosing spondylitis functional ındex), VAS ağrı (Visual Analog Scale) ve Leeds entezit indeksi ile değerlendirildi. Ayrıca her iki gruba HAQ (Health Assesment Questionnaire) ve Beck depresyon ölçeği uygulandı. Ayrıca ankilozan spondilit hastaları anti-TNFα ilaç kullanan ve kullanmayan şeklinde iki grup olarak karşılaştırıldı.
Bulgular: PainDETECT hasta grubunda kontrol grubuna göre istatistiksel olarak anlamlı derecede yüksekti. Ankilozan spondilit grubunda ortalama painDETECT 22,1 kontrol grubunda ise 9,95 idi (p
Sağlık çalışanlarında kas iskelet sistemi ağrıları ve depresyona etkili sosyodemografik, mesleki faktörlerin ve Fibromiyalji sendromu sıklığının saptanması
Authors: BÖLÜK ŞENLİKCİ Hüma 
Published: March 2021

Giriş: Kas iskelet sistemi ağrıları artmış fiziksel aktivite, duruş bozuklukları ve daha birçok biyopsikososyal nedene bağlı olarak ortaya çıkmaktadır. Sağlık çalışanları meslekleri gereği sürekli hasta ile yakın temasta bulunmak için yoğun fiziksel aktivitede bulunmak zorundadırlar. Sağlık çalışanlarında artmış fiziksel aktivite, uzun ve zorlu çalışma koşulları kas iskelet sistemi ağrılarına ek olarak depresif semptomlara da neden olmaktadır. Çalışmamızın amacı sağlık çalışanlarında kas iskelet sistemi ağrı şiddeti ve depresyona etkili faktörlerin saptanmasıdır.
Materyal-method: Kriterleri karşılayan 20-55 yaş arası 191 sağlık çalışanı çalışmaya dahil edildi. Sağlık çalışanları fibromiyalji tanı kriterleri, bölgesel ağrı şiddeti ve depresif semptomlar açısından vizuel analog skala (VAS) ve Beck depresyon ölçeği (BDÖ) ile değerlendirildi.
Bulgular: Katılımcıların çalıştığı birim, çalışma süresi ve nöbet tutulan süre ile katılımcıların VAS skorları, BDÖ skorları arasında herhangi bir ilişki saptanmadı. Katılımcıların haftalık çalışma süresi, aylık tutulan nöbet sayısı ile VAS ve BDÖ skorları arasında anlamlı ilişki saptanmıştır.Özellikle bel ağrısı skorları aylık tutulan nöbet sayısı ile ilişkilidir. Katılımcıların fibromiyalji sendromu sıklığı normal popülasyondan farklı görünmemektedir.
Sonuç: Sağlık çalışanlarında bel ağrısı aylık tutulan nöbet sayısı ile ilişkilidir. Haftalık çalışma süresinin de kas iskelet sistemi ağrı şiddeti ve depresif semptomlar üzerine etkili olduğu düşünülebilir. Uygun çalışma süreleri ve koşulları bu bağlamda göz önünde bulundurulmalıdır.
APLIKASI ROAD EVALUATION AND MONITORING SYSTEM (REMS) ( Studi Kasus : Ruas Jalan Magelang-Yogya, Sta.8+451 S.D Sta.10+000, Kabupaten Magelang, Provinsi Jawa Tengah )
Authors: Andrean Regi , Setyawan Ary , Djumari Djumari 
Published: March 2021

<p>Jalan merupakan sebuah prasarana transportasi darat yang berfungsi sebagai penghubung satu tempat ke tempat yang lain. Evaluasi perkerasan jalan harus dilakukan secara teratur untuk mengetahui kondisi perkerasan jalan. Evaluasi dewasa ini membutuhkan <em>software</em> yang dapat membantu memudahkan dalam survey kerusakan jalan baik dalam aspek biaya, waktu, tenaga maupun akses hasil survey kerusakan jalan tersebut. Penilaian kondisi perkerasan dapat dilakukan dengan menggunakan Analisa kerusakan menggunakan metode PCI REMS ( <em>Road Evaluation and Monitoring System</em> ) dengan penggolongan berdasarkan jenis, tingkat dan kelas kerusakannya. Metode ini memiliki skala penilaian lebih akurat dengan skala 0-100. Untuk mengukur keakuratannya, <em>software</em> REMS akan dibandingkan dengan perhitungan PCI secara manual.</p><p>Ruas Jalan yang akan diteliti adalah Ruas Jalan Magelang-Yogya sta Sta.8+451 – Sta.10+000. Magelang, Provinsi Jawa Tengah.Penelitian ini dilakukan dengan membagi 29 segmen yaitu mulai dari STA 8+451 sampai STA 10+000. Tiap kerusakan diukur dimensinya, kemudian data yang diperoleh dimasukan kedalam formulir yang disediakan dan <em>software</em> REMS yang kemudian dianalisa oleh program. Data yang telah diisi kedalam <em>sofware</em> REMS kemudian menunjukkan hasil nilai PCI. Hasil data ini kemudian akan disinkronkan ke server REMS yang dapat di akses oleh surveyor atau pihak yang telah melakukan <em>register </em>ke website infrasoft.id (server).</p><p>Hasil evaluasi kondisi permukaan perkerasan Jalan Magelang-Yogya STA 8+450 sampai STA 10+000 menggunakan metode PCI Manual menghasilkan nilai sebesar 53,72 dengan kategori “<em>Poor</em>”. Hasil perhitungan metode <em>Pavement Condition Index</em> (PCI) dengan menggunakan aplikasi <em>Road Evaluation and Monitoring System</em> (REMS) pada ruas tersebut didapatkan nilai sebesar 64,86 dengan kategori “<em>Fair</em>”. Perbandingan nilai kondisi PCI manual dan PCI REMS dari total 29 segmen, diperoleh 27 segmen yang mempunyai pesentase simpangan lebih dari atau sama dengan 1% dengan simpangan rata-rata sebesar 11%. Nilai PCI REMS cenderung lebih tinggi dibandingkan Nilai PCI Manual. Hal ini disebabkan karena perbedaan keakuratan dalam pembacaan grafik (DV dan CDV) dan dalam metode PCI Manual untuk pemilihan nilai CDV, dipilih dari nilai CDV paling tinggi tetapi untuk PCI REMS diambil nilai dengan CDV urutan pertama.</p>
PENGARUH VARIASI ANYAMAN LATERAL SERAT CANTULA (AGAVE CANTULA ROXB) PADA TEXTILE REINFORCED CONCRETE (TRC) TERHADAP KUAT TEKAN BETON
Authors: Purwanto Edy , Kristiawan Stefanus Adi , Prabaswara Dhanes 
Published: March 2021

<p>Penggunaan beton bertulang telah menjadi material pokok sebagai struktur penguat suatu bangunan. Beton yang mengalami kerusakan maupun degradasi kekuatan tersebut dapat diperbaiki untuk mengembalikan atau menambah kekuatan dan kemampuannya dalam menopang struktur seperti sedia kala. <em>Textile Reinforced Concrete</em> (TRC) merupakan komposit yang terdiri dari tekstil yang berfungsi sebagai <em>reinforcement</em> dan <em>fine-grained concrete</em> sebagai matriks. <em>Textile </em><em> </em><em>reinforcement</em><em> </em>yang digunakan umumnya berupa material <em>non-nature</em>, seperti serat kaca tahan alkali (AR), aramid, basalt dan <em>carbon fabrics.</em> Terdapat pula material alam yang dapat digunakan pada <em>textile reinforcement</em>, salah satunya yaitu serat cantula. <em>Agave Cantula Roxb</em> merupakan serat alam yang memiliki kemampuan mekanik yang tinggi. <em>Textile Reinforced Concrete </em>(TRC) yang digunakan pada penelitian ini terdiri dari silinder beton sebagai matrik dan <em>reinforcement</em> berupa anyaman serat cantula yang dikekang pada beton yang memiliki variasi arah penulangan lateral sesuai dengan dimensi yang ditentukan. Variasi anyaman tersebut digunakan untuk mengetahui pengaruh yang paling optimal pada kuat tekan beton. Variasi anyaman serat cantula yang digunakan adalah 10 mm x 10 mm, 15 mm x 10 mm , 20 mm x 10 mm. Pengujian pada <em>Textile Reinforced Concrete </em>dilakukan pada umur 28 hari. Hasil penelitian menunjukkan bahwa nilai kuat tekan aktual (f’c) yang terbesar yaitu pada benda uji dengan kode TRC 100, sebesar 18,33 MPa. Selain itu, terjadi peningkatan kekuatan pada beton yang telah terkekang oleh serat cantula terhadap beton normal. Prosentase peningkatan nilai kuat tekan terbesar yaitu pada benda uji dengan kode TRC 100 sebesar 1,89 %.</p>
Evaluasi Jalur Pejalan Kaki Di Universitas Sebelas Maret Kentingan Surakarta
Authors: Handayani Dewi , Sumarsono Agus , Hasanah Fina 
Published: March 2021

<p>Kawasan kampus sudah selayaknya memberikan kemudahan dan kenyamanan kepada yang beraktivitas di dalamnya. Diantaranya adalah jalur pedestrian untuk menunjang pergerakan lalu lintas dan kelancaran aktivitas masyarakat khususnya di Universitas Sebelas Maret (UNS). Di UNS sudah terdapat jalur pedestrian, baik jalur yang lama maupun yang baru di bangun. Untuk mengetahui seberapa baik jalur yang ada sekarang, perlu diadakan observasi untuk mengevaluasinya. Tujuan dari penelitian ini adalah<em> </em><strong>untuk mengetahui persentase skala nilai dan kondisi fasilitas jalur pejalan kaki di UNS</strong><strong>.</strong> Metode pengambilan data lapangan menggunakan teknik observasi berupa survei pengukuran. Metode analisis yang dilakukan yakni deskriptif kuantitatif dengan menggunakan ukuran skala nilai fasilitas dan evaluasi melalui perbandingan proporsi kondisi eksisting tiap ruas terhadap standar peraturan Permen PU 03/PRT/M/2014. Persentase skala nilai fasilitas jalur pejalan kaki di UNS : Zona V memiliki lebar trotoar terbaik dengan nilai skala 3 sebesar 81%; trotoar Zona II yang tidak licin saat hujan hanya sebesar 14%; lebar jalur perabot jalan dan jalur hijau pada Zona II sangat baik dengan nilai skala 3 sebesar 100%; beda tinggi trotoar dengan jalur perabot jalan dan jalur hijau terbilang kurang baik dengan nilai skala 1 lebih dari 50% untuk semua Zona jalur pejalan kaki; lebar <em>ramp </em> rata-rata kurang dari standar hampir di semua Zona, kecuali pada Zona V dengan nilai skala 2 sebesar 82%; kemiringan <em>ramp </em>rata-rata baik dengan nilai skala 2 lebih dari 50%; tekstur <em>ramp </em>tidak licin pada semua Zona; dan hampir seluruhnya memiliki lebar tepi pengaman <em>ramp </em>yang memenuhi standar. Kondisi fasilitas jalur pejalan kaki di UNS : trotoar dan <em>ramp </em>dalam kondisi baik dan bersih serta rata-rata dapat dikatakan tidak licin saat hujan, hanya untuk <em>ramp</em> perlu dilengkapi dengan pegangan rambatan; perlu ditambah jumlah tempat duduk, tempat sampah dan pagar pengaman.</p>