bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of lacosamide in neonatal‐onset super‐refractory status epilepticus: a case report
Authors: Bertozzi Veronica , Bonardi Claudia M. , Biscalchin Gaia , Tona Clarissa , Amigoni Angela , Sartori Stefano 
Published: July 2021

AbstractWe report the case of a previously healthy newborn who developed super‐refractory status epilepticus after Group B streptococcal meningoencephalitis. After administration of first‐, second‐ and third‐line anticonvulsants without resolution of status epilepticus, we started intravenous lacosamide as adjunctive therapy to phenobarbital, phenytoin and continuous infusion of ketamine and midazolam. After administration of lacosamide, we observed a clear‐cut improvement in the neurological clinical condition coupled with seizure control on continuous video‐EEG monitoring, even after suspension of all other medications except for phenobarbital. No adverse effects ascribable to lacosamide were reported. The available data regarding the use of lacosamide for status epilepticus in adults and children are promising, although there is as yet only anecdotal evidence for neonatal status epilepticus. Its lack of potential interactions, good tolerability and the option of intravenous use lend to its appeal as treatment for status epilepticus. To the best of our knowledge, this is one of the first reported cases of effective lacosamide infusion in neonatal‐onset super‐refractory status epilepticus. This evidence should prompt further investigation on efficacy and safety of lacosamide to support its use in this population.
IVF-ICSI/ET başarısızlığı olan infertil hastalarda histeroskopi bulgularının değerlendirilmesi
Authors: TÜREYİCİ Lena , KAHVECİ Bekir , ÜRÜNSAK İbrahim Ferhat 
Published: July 2021

fertilizasyon-intrastoplazmik sperm injeksiyonu/embriyo transferi) yapılmış ve başarısız olunmuş hastalarda histeroskopi ile intrauterin patolojileri saptamak ve bu patolojileri sınıflandırıp değerlendirilmesidir.
Gereç ve Yöntem: Bu retrospektif çalışma 2013-2019 yılları arasında Çukurova Üniversitesi Tıp Fakültesi Balcalı Hastanesi Üreme Endokrinolojisi ve İnfertilite Bölümü’nde yapılmıştır. Bu çalışmaya, infertilite polikliniği’ne başvuran primer veya sekonder infertilite tanılı, daha önceden IVF-ICSI/ET yapılıp başarısızlıkla sonuçlanan ve bu nedenle histeroskopi uygulanan hastalar dahil edilmiştir.
Bulgular: Çalışmaya alınan 228 hastanın histeroskopi sonuçları değerlendirildi. Bunlardan, %42,5’i (n=97) normal histeroskopik bulgulara, %57,5’i (n=131) anormal histeroskopik bulgulara sahipti. Bu anormal bulgular incelendiğinde, en sık izlenen patoloji endometrial polip %23,1 (n=36) idi. Diğer bulgular; intrauterin sineşi %20,5 (n=32), servikal patoloji %18,6 (n=29), servikal stenoz %13,5 (n=21), uterin subseptum %10,9 (n=17), myoma uteri %4,5 (n=7), arkuat uterus %3,2 (n=5), T-shape uterus %3,2 (n=5), intrauterin enfeksiyon %1,9 (n=3) ve vajinal septum %0,6 (n=1) idi.
Sonuç: İmplantasyon başarısızlığı olan hastalarda nedene yönelik ek incelemeler yapılmalıdır. Histeroskopinin IVF üzerine olan pozitif etkisi endometrial kavitedeki lezyonları saptama ve tedavi etmesi ile ilişkilidir. Ayrıca histeroskopi, diğer araştırma yöntemleri tarafından gözden kaçırılan intrauterin patolojileri saptayabilir. Böylece IVF başarısızlığı olan hastaların yönetimine olumlu katkı sağlayabilir.
GM2 gangliosidoses: evaluation of clinical, biochemical and genetic findings of patients with three novel mutations
Authors: BİLGİNER GÜRBÜZ Berrak , BULUT Fatma Derya , KOÇ UÇAR Habibe , SARIGEÇİLİ Esra , SARIKEPE Bilge , ÖZALP YÜREĞİR Özge 
Published: July 2021

Purpose: The aim of this study is to evaluate the diagnosis characteristics, clinic findings, phenotypical and genotypical features of children with GM2 gangliosidoses.
Materials and Methods: The file records of 14 patients diagnosed with GM2 gangliosidoses in our clinic were retrospectively reviewed. The GM2 gangliosidoses diagnosis was confirmed by determining the levels of serum total hexosaminidase and β-hexosaminidase activity with genetic analysis.
Results: We identified a total of seven different mutations, three of which were novel (one in the HEXA gene and two in the HEXB gene) in 14 patients. We found a high frequency of c.1100_1111del (p.Gly367_Tyr370del) mutation in HEXA affected patients. The mean age at diagnosis was 13.46.3 months and 14.24.2 months for patients with Tay–Sachs disease (TSD) and Sandhoff disease (SD) respectively. Neuroregression was present in 92.9% of our patients. Of the 14 patients, 11 had epilepsy, 10 had developmental delay, 6 had hyperacusis, 6 had cherry-red spots and 6 had macrocephaly, but none of the patients had organomegaly.
Conclusion: GM2 gangliosidoses disease should be considered for children with developmental regression and/or delay. For early diagnosis, enzyme analysis and gene detection should be performed in children with suspected GM2 gangliosidoses in the presence of clinical findings.
Çocuk endokrinolojisi polikliniğinde boy kısalığına tanısal yaklaşım ve yeşil alan uygulamasının etkinliği
Authors: TURAN İhsan 
Published: July 2021

Amaç: Bu çalışmada ayaktan pediatri polikliniğine boy kısalığı şikâyeti ile getirilen olguların ve onlara yapılan tetkiklerin analizi amaçlanmıştır.
Gereç ve Yöntem: Şanlıurfa Eğitim ve Araştırma Hastanesi Çocuk Endokrinolojisi polikliniğine 15 aylık süreçte boy kısalığı şikâyeti ile başvuran ardışık olgular retrospektif olarak incelenmiştir. Yönlendirme şekilleri, ilk değerlendirmemiz öncesindeki öyküleri, oksolojik analizleri ve tetkik sonuçları kayıt altına alınmıştır.
Bulgular: Yaş ortalaması 9.44 olan 1835 ardışık olgu çalışmaya alındı. Olguların %43.6’sının hatalı yönlendirildiği tespit edildiİncelenen tetkiklerde en sık saptanan patolojilerin sırası ile anemi, Giardia üremesi ve Çölyak Hastalı otoantikor pozitifliği olduğu belirlendi. Analiz edilen 1026 kan örneğinde, kalsiyum, fosfor, alkalen fosfataz, sodyum ve kreatinin tetkiklerinin anormal sonuç gözlenmedi, sadece bir potasyum tetkikinin normalin üstünde olduğu saptandı.
Sonuç: Çalışmamızda boy kısalığı şikâyeti ile çocuk endokrinolojisi kliniğine başvurmuş olguların %43.6’sının, yaş ve cinsiyetine göre normal boy aralığında olduğu tespit edilmiştir. Hekim kararı ile yönlendirilen olguların %40.4’ünün boy ölçümü yapılmadan sevk edilmiş olduğu tespit edilmiştir ve boy kısalığı şikâyeti ile başvurmuş yüksek sayıda olgunun incelenmesi ile bölgenin bu sık rastlanılan şikâyete yaklaşımı raporlanmıştır. Boy kısalığı saptanan çocuklarda rutin olarak istenilen tetkiklerin birçoğunda patoloji saptanamamış olması, bu tetkiklerin gerekliliğini ve verimini tartışmaya açmıştır.
Quality of life, depression and self-perceived burden among geriatric and non-geriatric hemodialysis patients
Authors: Oztop Kenan Evren , Cetin Ferhat , Genc Ahmed Bilal , Varim Ceyhun , Sipahi Savas 
Published: July 2021

Background: Many hemodialysis patients need support at various levels from their relatives while performing their daily activities. The ‘burden’ of these needs of patients on their relatives and their negative effects on their lives have been shown in the literature. The aim of the study was to evaluate the ‘care burden’ in terms of the patient.Methods: The patient who had received hemodialysis for at least 3 months was included in the study. A patient identification form including demographic data and medical history data was prepared. The Perceived care burden scale, Beck depression scale and WHO Quality of life questionnaire were applied to the patients.Results: A statistically significant positive correlation was found between SPBS and BDI (p<0.001, r=0.820). A statistically significant negative correlation was observed between the perceived care burden and all sub-dimensions of the quality of life scale (p<0.001). The frequency of comorbidity in the geriatric group was higher than non-geriatric group. A statistically significant positive correlation was found between comorbidity and QOL (p<0.001). The median scores of all sub-dimensions of the QOL scale were lower in geriatric group and there were significance differences except environment dimension.Conclusions: The self-perceived burden on caregivers of hemodialysis patients was positively associated with depression and negatively associated with QOL. Decrease in QOL was more pronounced in geriatric patients.
Pay satisfaction among doctors and nurses in a tertiary hospital in South-South Nigeria
Authors: Ozumba Lillian N. , Alabere Ibidabo D. 
Published: July 2021

Background: Employee pay is an important area in human resources management which influences individual behaviour including absenteeism in organizations. Pay satisfaction is a primary concern to employees because of its importance in satisfying their economic needs. The research was conducted to determine the occurrence and factors affecting employee pay satisfaction among doctors and nurses working in a tertiary hospital. Methods: A descriptive, cross-sectional study design was used for this research on a sample of 320 doctors and nurses in a tertiary hospital that were selected using stratified sampling technique. An interviewer-administered questionnaire containing pay satisfaction details amongst others was used to collect data from the respondents. The data was analysed using statistical package for social sciences version 22 and statistical significance was set at 0.05. The results were presented in tables.Results: The prevalence of pay satisfaction in this study was 16.9%. Specifically, monthly earning (p=0.003) and job category (p=0.008) were found to be significantly associated with pay satisfaction.Conclusions: This study showed that the prevalence of respondents that were satisfied with their pay was low. There is need to apply practical measures that will improve pay satisfaction among doctors and nurses so as to improve productivity in the health sector.
LAMA KALA II PERSALINAN PADA IBU PRIMIGRAVIDA YANG MENGIKUTI SENAM DAN TIDAK SENAM HAMIL
Authors: Hasanah Uswatun , Anis Wahyul , Purwanto Bambang 
Published: July 2021

Abstrak Latar Belakang: Kehamilan dan persalinan merupakan proses alamiah bagi wanita namun peluang terjadinya komplikasi bisa saja terjadi. Komplikasi yg terjadi selama persalinan menjadi penyumbang angka kematian ibu di Indonesia seperti kala II memanjang. Primigravida merupakan faktor risiko terjadinya kala II memanjang, jika lebih dari 2 jam berisiko 1.42 kali menyebabkan trauma jalan lahir dan perdarahan. Upaya pemerintah untuk mencegah komplikasi tersebut dengan menyelenggarakan senam hamil untuk menyeimbangkan emosional, mental, fisik dan spiritual sehingga mengurangi risiko persalinan lama. Penelitian ini bertujuan untuk mengetahui perbedaan pada durasi lama kala II persalinan pada primigravida yg mengikuti senam hamil dan tidak senam hamil. Metode: Penelitian ini adalah anlitik observasional dengan rancangan cross-sectional, jumlah sampel 92 responden dengan teknik total sampling. Variabel independen adalah senam hamil dan variabel dependen yaitu lama kala II persalinan. Instrumen yang digunakan adalah rekam medis dan kuesioner. Analisis data menggunakan uji Mann Whitney Test. Hasil: Hasil penelitian menunjukkan variabel durasi kala II persalinan p = 0,000 (p<0,05). Kesimpulan: Durasi kala II persalinan pada primigravida yang mengikuti senam hamil lebih cepat dibandingkan dengan ibu yang tidak senam hamil. AbstractBackground: Pregnancy and childbirth are natural processes for women but the chance of complications can occur. Complications that occur during labor contribute to the maternal mortality rate in Indonesia such as elongation in the second period. Primigravida is a risk factor for prolonged stage II, if more than 2 hours the risk is 1.42 times causing trauma to the birth canal and bleeding. Government efforts to prevent these complications by carrying out pregnancy exercises to balance emotional, mental, physical and spiritual thus reducing the risk of prolonged labor. The aim of this study was to determine the differences in the duration of the second stage of labor in primigravidas who followed and did not follow pregnancy exercise. Method: This study was an observational analytic with a cross-sectional design, with a total sample of 92 respondents with a total sampling technique. The independent variable is pregnancy exercise and the dependent variable is the duration of second stage of labor. The instruments used medical records and questionnaires. Data analysis using the Mann Whitney Test. Results: The results showed the variable duration of second stage of labor p = 0,000 (p <0.05). Conclusions: The duration of the second stage of labor in primigravidas who followed pregnancy exercise was faster than did not follow pregnancy exercise.
PENGARUH IMT IBU HAMIL PREEKLAMPSIA DENGAN LUARAN PERINATAL
Authors: Rahmawati Fadhilah , Aldika Akbar Muhammad Ilham , Atika Atika 
Published: July 2021

Abstrak Latar belakang dan tujuan : Preeklampsia merupakan masalah komplikasi kehamilan yang menyumbang kematian ibu tertinggi di Jawa Timur. Preeklampsia dengan Indeks Massa Tubuh ibu obesitas akan meningkatkan perburukan luaran maternal dan perinatal. Penelitian ini bertujuan untuk menganalisis hubungan Indeks Massa Tubuh ibu preeklampsia dengan luaran maternal dan luaran perinatal. Metode: penelitian ini adalah analitik obsevasional dengan rancangan cross sectional, jumlah sampel 60 rekam medis ibu dan bayi baru lahir di Rumah Sakit Universitas Airlangga. Sampel terdiri dari ibu preeklampsia semua kategori IMT yaitu underweight, normal, overweight, obesitas grade I,II, dan III. Luaran perinatal yang diteliti adalah kematian perinatal, kelahiran prematur, IUGR (Intrauterine growth restriction), asfiksia, bayi berat lahir rendah, Sindrom Respiratori Distres (SRD), sepsis, Necrotizing Enterocolitis (NEC) dan Intraventrikular Hemorrhage (IVH). Hasil: Indeks Massa Tubuh Ibu preeklampsia tidak berhubungan dengan luaran perinatal antara lain kelahiran prematur, IUGR, asfiksi, BBLR dan komplikasi dini Kesimpulan: tidak ada perbedaan luaran maternal dan luaran perinatal pada berbagai Indeks massa tubuh ibu preeklampsiaAbstract Background and purpose : Preeclampsia is a problem of the pregnancy complications that has the highest maternal mortality in East Java. Preeclampsia with body mass index of obese mothers will increase the deterioration in maternal and perinatal outcomes. This study aims to analyze the body mass index of preeclampsia mothers with maternal and perinatal outcomes. Methods: This is an observational with cross-sectional design study, a sample of 60 pregnant women and newborn medical records at Universitas Airlangga Hospital. The sample consisted of preeclamptic women in all categories of body mass index such as underweight, normal, overweight, obesity grade I,II, and III. The perinatal outcomes observed are perinatal death, preterm birth, Intrauterine Growth Restriction (IUGR), asphyxia, low birth weight, Respiratory Distress Syndrome (RDS), sepsis, Necrotizing Enterocolitis (NEC), and Intraventricular Hemorrhage (IVH). Results: There is no significant association between body mass index of preeclampsia with perinatal outcomes. Which include preterm birth, Intrauterine Growth Restriction (IUGR), asphyxia, low birth weight and early complications Conclusion: there were no difference on maternal and perinatal outcomes in all categories Body mass index of preeclamptic women
PRIMIGRAVIDA MEMILIKI KECEMASAN YANG LEBIH SAAT KEHAMILAN
Authors: Hastanti Heni , Budiono Budiono , Febriyana Nining 
Published: July 2021

Abstrak Latar Belakang: Kecemasan merupakan salah satu gangguan jiwa yang umum terjadi pada masa kehamilan. Prevalensi kecemasan ibu hamil di negara berkembang rata-rata mencapai 20% atau lebih. Kecemasan ibu hamil berbeda-beda tergantung pada faktor yang mempengaruhi dan kemampuan ibu beradaptasi dalam menciptakan kondisi psikologis. Penelitian ini bertujuan untuk mengetahui perbedaan kejadian kecemasan ibu hamil primigravida dan multigravida. Metode: Jenis penelitian adalah analitik observasional dengan desain studi cross sectional comparative untuk membandingkan perbedaan kecemasan primigravida dan multigravida dengan kuesioner. Populasi adalah semua ibu hamil yang tercatat dan berkunjung di Puskesmas Jenggot Kota Pekalongan. Sampel dengan teknik consecutive sampling yang dibedakan menjadi dua kelompok yaitu kelompok primigravida dan multigravida. Masing-masing kelompok 43 orang dengan kriteria inklusi kehamilan tunggal, usia ibu saat hamil 20-35 tahun, kehamilan fisiologis. Penelitian ini dilakukan di Puskesmas Jenggot Kota Pekalongan pada Bulan Februari-April 2019. Analisis data dilakukan dengan teknik komparasi Mann-Whitney, Chi Square dan Independent Samples T-Test. Hasil: Karakteristik responden antara primigravida dan multigravida diketahui bahwa karakteristik yang berbeda adalah usia ibu hamil (p=0,000), pendidikan (p=0,009) dan tipe keluarga (p=0,000), disimpulkan bahwa ada perbedaan usia, pendidikan dan tipe keluarga. Rata-rata skor kecemasan pada ibu hamil primigravida yaitu 70,74 sedangkan pada multigravida yaitu 65,70. Hasil uji Independet Samples T-Test didapatkan nilai p sebesar 0,035 sehingga disimpulkan terdapat perbedaan kecemasan pada ibu hamil primigravida dan multigravida. Kesimpulan: Kecemasan pada primigravida lebih tinggi sebesar 7,67% dibandingkan dengan multigravida berdasarkan rata-rata skor kecemasan.Abstract Background: Anxiety is one of the common mental disorders in pregnancy. The prevalence of maternal anxiety in developing countries reaches an average of 20% and more. The anxiety in pregnancy depends on the influencing factors and the ability of the mothers to adapt and create a psychological condition. Therefore, this research aims to find out the differences in the prevalence of anxiety in primigravida and multigravida pregnancy. Method: The type of this research is analytic observational study with comparative cross-sectional design and questionnaires to compare the incidence of anxiety in primigravida and multigravida. The research population was all pregnant women who visited and recorded at Jenggot Public Health Center, Pekalongan. The sample was taken with consecutive sampling technique and divided into two groups, primigravida group, and multigravida group. Each group has 43 people with inclusion criteria of a single pregnancy, maternal age between 20 to 35 year
HUBUNGAN RIWAYAT SAKIT DENGAN KEJADIAN STUNTING PADA BALITA
Authors: Nurbawena Hasanah , Utomo Martono Tri , Yunitasari Esti 
Published: July 2021

AbstrakLatar belakang : Kejadian stunting merupakan salah satu masalah gizi pada anak yang memiliki prevalensi tinggi di Indonesia. Cut off point kejadian stunting tidak boleh lebih dari 20%, sedangkan jumlah kejadian stunting di Surabaya sebanyak 22,8%. Salah satu penyebab tingginya kejadian stunting yaitu penyakit infeksi. Penelitian ini bertujuan untuk mengetahui hubungan riwayat sakit dengan kejadian stunting pada balita. Metode : Penelitian ini merupakan penelitian analitik observasional dengan menggunakan rancang penelitian case control. Jumlah sampel yang diteliti sebanyak 40 balita dengan usai 24-36 bulan di wilayah kerja Puskesmas Simomulyo Surabaya. Sampel penelitian balita stunting merupakan kelompok kasus dan balita non-stunting merupakan kelompok kontrol. Pengambilan data untuk kelompok kasus menggunakan purposive sampling dan pada kelompok kasus menggunakan matching sampling dengan menyesuaikan usia bayi dan jenis kelamin pada kelompok kasus. Pengumpulan data mengguanakan instrumen kuisioner. Uji statistik menggunakan chi square Hasil : Hasil penelitian ini didapatkan balita stunting memiliki riwayat sakit sebanyak 90%, sedangkan pada balita non-stunting sebanyak 45%. Uji statistik menggunakan mengenai hubungan riwayat sakit dengan kejadain stunting pada balita dengan uji Chi square didapatkan hasil yang signifikan yaitu p=0,002 (<0,05) dan OR 4,889. Kesimpulan : Balita stunting memiliki riwayat sakit lebih sering daripada balita non-stunting.AbstractBackground: . The incidence of stunting is one of the nutritional problems in children who have a high prevalence in Indonesia. The cut off point for stunting events should not be more than 20%, while the number of stunting events in Surabaya is 22.8%. One of the causes of the high incidence of stunting is an infectious disease. This study aimed to determine the relationship of a history of illnes with the incidence of stunting in infants. Method: This research was an observational analytic study using a case control research design. The number of samples were 40 toddlers (20 toodlers with stunting and 20 toodlers with non-stunting) aged 24-36 months in the working area of the Simomulyo Primary Health Care in Surabaya. The stunting toddlers belonged to a case group and non-stunting toddlers belonged to a control group. Data collection of case group had used purposive sampling and that control group used matching sampling by adjusting the baby's age and gender in the case group. Data was obtained by questionnaire instrument.Data was analysis by Chi square Results: The persentage of stunting toddlers who had a history of illness was 90%, while the non-stunting toddlers had a history of illness was 45%. There was relationship between the history of infectious diseases and the occurrence of stunting in toodler p=0,022 (<0,05) and OR=4,338. Conclusion: Stunting toddlers have a history of pain more often than non-stunting toddlers
PENGARUH PAPARAN MEDIA MASSA TERHADAP LITERASI KESEHATAN REPRODUKSI REMAJA PONDOK PESANTREN
Authors: Isyroofanaa Esti , Faizah Zakiyatul , Utomo Martono Tri 
Published: July 2021

Abstrak Latar Belakang : Kesehatan merupakan salah satu di antara tiga faktor utama yang mempengaruhi Indeks Pembangunan Manusia (IPM) selain pendidikan dan pendapatan. Media dan sumber informasi kesehatan yang semakin berkembang menjadikan masyarakat lebih melek kesehatan. Pondok Pesantren Putri Hidayatul Mubtadi-aat Lirboyo Kediri menerapkan dalam penggunaan media massa mutlak tidak diperbolehkan seperti televisi, radio atau handphone. Metode : Penelitian ini merupakan penelitian analitik observasional dengan menggunakan pendekatan cross sectional. Besar sampel sebanyak 260 santri remaja umur 10 sampai 19 tahun sesuai dengan kriteria inklusi. Pengambilan data kuantitatif dilakukan dengan metode Non-Random Sampling dengan teknik consecutive sampling. Variabel independen dalam penelitian ini adalah paparan media massa, sedangkan variabel dependennya adalah tingkat health literacy kesehatan reproduksi remaja. Untuk mengetahui tingkat signifikan, data yang terkumpul akan diuji dengan uji regresi logistik sederhana dengan menggunakan derajat kepercayaan 95%. Hasil : ada pengaruh kualitas paparan media (p=0,006), kuantitas paparan media massa (p=0,002) terhadap tingkat health literacy. Kesimpulan : diperlukan lebih banyak paparan media yang berkualitas untuk meningkatkan health literacy terkait kesehatan reproduksi pada santri Pondok Pesantren Putri Hidayatul Mubtadi-aat Lirboyo Kediri.Abstract Background: Health is one of the three main factors that influence the Human Development Index (HDI) in addition to education and income. Media and health information sources that are increasingly developing make people more health literate. Islamic Boarding School, Lirboyo Kediri, is not permitted to use the mass media as television, radio or cellphones. Method: This research was an observational analytic study using a cross sectional approach. The size of samples was 260 young students aged 10 to 19 years according to the inclusion criteria. Quantitative data were retrieved Non-Randomly using consecutive sampling technique. The independent variable in this study was mass media exposure, while the dependent variable is the level of health literacy of adolescent reproductive health. To find out the effect, a simple logistic regression was applied using 95% confidence level. Results: the quality of the media that were accessed (p=0.006), the quantity of media that were accessed (p=0.002), age (p=0.000) and the training experience (p=0.000) affected health literacy individually. Conclusion: there is needs of increasing access to quality mass media in order to improve health literacy aming students of Pondok Pesantren Putri Hidayatul Mubtadi-aat Lirboyo Kediri.