bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between multi-scale climate factors and performance of ecological engineering on the Loess Plateau, China
Authors: He Panxing , Ma Jun , Han Zhiming , Shi Mingjie , Xu Dongxiang , Sun Zongjiu 
Published: April 2021

AbstractThe long-term “Grain-to-Green Program” (GGP) on China’s Loess Plateau is a major global ecological engineering project which has significantly boosted vegetation renewal. Some studies have found that the rate of restoration is quite rapid during the implementation of ecological engineering, however, the influence of multi-scale climatic conditions on the performance of ecological engineering is unclear. In this study, multiple sources of remote sensing data were used to estimate the dynamics of vegetation structural and functional indicators, water-related local climatic factors, and atmospheric circulation factors. These datasets were also used to detect possible causes for vegetation restoration on the Loess Plateau over the past 20 years. The results show that widespread increases in rates of normalized difference vegetation indexes (NDVI), leaf area indexes (LAI), gross primary production (GPP), and aboveground biomass carbon (ABC) during 2000–2016 were significantly higher than before 2000. GPP was significantly correlated with rainfall and surface runoff on a monthly scale, and there were significant positive correlations between GPP and atmospheric circulation. Our results demonstrate that both vegetation structural and functional indicators rapidly increase, and ecological engineering greatly accelerated vegetation restoration after 2000. Local climatic conditions and atmospheric circulation patterns enhance vegetation growth and impact of ecological engineering.
IGF-1R nuclear import and recruitment to chromatin involves both alpha and beta subunits
Authors: Mills Jack V. , Osher Eliot , Rieunier Guillaume , Mills Ian G. , Macaulay Valentine M. 
Published: April 2021

AbstractMature type 1 insulin-like growth factor receptors (IGF-1Rs) are heterotetrameric structures comprising two extracellular α-subunits disulphide-bonded to two transmembrane β-subunits with tyrosine kinase activity. IGF-1R is a well-known cell surface mediator of malignant growth, with an incompletely understood role upon nuclear import as a transcriptional regulator. Previous characterisation of nuclear IGF-1R focused on IGF-1Rβ. Here, we aimed to clarify the source of nuclear IGF-1R and investigate whether α-subunits contribute to nuclear IGF-1R function. Using prostate cancer cell lines DU145 and 22Rv1 we detected nuclear α- and β-subunits, with increase in nuclear signal upon IGF-treatment and reduction in response to IGF-1R inhibitor BMS-754807. Following biotinylation of cell surface proteins, biotinylated α- and β-subunits were detected in nuclear extracts of both cell lines. Furthermore, α- and β-subunits reciprocally co-precipitated from nuclear extract. Finally, we detected recruitment of both subunits to regulatory regions of chromatin, including the promoter of the oncogeneJUN, that we previously identified in ChIP-seq as sites of IGF-1Rβ enrichment. These data confirm the cell surface origin of nuclear IGF-1R, suggest the presence of nuclear αβ complexes and reveal that both IGF-1Rα- and β-subunits contribute to pro-tumorigenic functions of nuclear IGF-1R.
Nutritional niche separation between native roe deer and the nonnative fallow deer—a test of interspecific competition
Authors: Rautiainen Heidi , Bergvall Ulrika A , Felton Annika M , Tigabu Mulualem , Kjellander Petter 
Published: April 2021

AbstractOn an evolutionary time scale, competition for food drives species formation by genetic adaptations to the environment and subsequent niche separation. On a short-term scale, animals use different strategies to meet their nutritional requirements, which ultimately influence their fitness. Understanding these adaptations in herbivores is especially important in temperate climates where animals have adapted both physiologically and behaviorally to seasonal variations in order to meet their nutritional requirements. The aim of this project was to investigate temporal variation in chemical composition of rumen content between two coexisting species of large herbivores, the native roe deer (Capreolus capreolus L.) and the introduced fallow deer (Dama dama L.), as well as a potential effect of competition on niche separation (interspecific differences in rumen nutrient composition). We analyzed 345 rumen samples collected from animals at one 95 km2estate, Koberg, in southwestern Sweden. Based on samples from all seasons, temporal variation in nutrient composition and interspecific differences between the two deer species were investigated under two contrasting fallow deer population densities. Results revealed that nutrient composition varied between species and across seasons. Roe deer had a higher proportion of rumen protein compared to fallow deer, with the highest proportions in spring. In contrast, fallow deer had a higher proportion of rumen hemicellulose compared to roe deer in spring, while no differences in nutrient composition between species could be found in fall. Overall, there were greater differences between the two species when fallow deer density was high and competition likely more pronounced than when fallow deer density was low. The results from this study can be used to understand interspecific competition and how it fosters niche separation between coexisting large herbivores.
Exploring the Relationships Between Resilience and News Monitoring with COVID Distress in Health Profession Students
Authors: Yu Allison , Wilkes Michael , Iosif Ana-Maria , Rea Margaret , Fisher Alice , Fine Jeffrey , Perry Ross , Rice Elizabeth , Jandrey Karl , Griffin Erin , Sciolla Andres 
Published: April 2021

Abstract
Objective
Alarming rates of anxiety and burnout in pre-clinical health profession trainees are now challenged by additional COVID-19 stressors. This study explored COVID-related stressors among first-year medical, physician assistant, nurse practitioner, and veterinary medical students. The authors examined associations between resilience, news monitoring, and COVID stress.

Methods
Students completed an online questionnaire that included the Brief Resilience Scale at their matriculation in August 2019. Survey results were linked to demographic information collected by all schools. A follow-up survey in May 2020 included original questions on COVID-19 stressors and news monitoring. Statistical analyses included descriptive statistics and multivariable linear regression models.

Results
Across schools, 74% (266/360) provided consent for the 2019 survey, and 76% (201/264) responded to COVID-19 questions in the follow-up 2020 survey. Students were “extremely” or “very” concerned about family members getting infected (n = 71, 76% School of Medicine (SOM); n = 31, 76% School of Nursing (SON); n = 50, 75% School of Veterinary Medicine (SVM)) and curriculum schedule changes (n = 72, 78%, SOM; n = 28, 68% SON; n = 52, 79% SVM). Greater frequency of COVID news monitoring was associated with greater COVID-related stress (p = 0.02). Higher resilience at matriculation was associated with lower COVID-related stress ten months later (p < 0.001).

Conclusions
Amid COVID-19 uncertainty, health science schools should address the immense student stress regarding curriculum disruptions. The results of this study underscore the powerful role of resilience in protecting against stress not only during the known academic rigor of health professions training but also during unprecedented crises.
3D printed ceramics as solid supports for enzyme immobilization: an automated DoE approach for applications in continuous flow
Authors: Valotta Alessia , Maier Manuel C. , Soritz Sebastian , Pauritsch Magdalena , Koenig Michael , Brouczek Dominik , Schwentenwein Martin , Gruber-Woelfler Heidrun 
Published: April 2021

AbstractIn recent years, 3D printing has emerged in the field of chemical engineering as a powerful manufacturing technique to rapidly design and produce tailor-made reaction equipment. In fact, reactors with complex internal geometries can be easily fabricated, optimized and interchanged in order to respond to precise process needs, such as improved mixing and increased surface area. These advantages make them interesting especially for catalytic applications, since customized structured bed reactors can be easily produced. 3D printing applications are not limited to reactor design, it is also possible to realize functional low cost alternatives to analytical equipment that can be used to increase the level of process understanding while keeping the investment costs low. In this work, in-house designed ceramic structured inserts printed via vat photopolymerization (VPP) are presented and characterized. The flow behavior inside these inserts was determined with residence time distribution (RTD) experiments enabled by in-house designed and 3D printed inline photometric flow cells. As a proof of concept, these structured inserts were fitted in an HPLC column to serve as solid inorganic supports for the immobilization of the enzyme Phenolic acid Decarboxylase (bsPAD), which catalyzes the decarboxylation of cinnamic acids. The conversion of coumaric acid to vinylphenol was chosen as a model system to prove the implementation of these engineered inserts in a continuous biocatalytic application with high product yield and process stability. The setup was further automated in order to quickly identify the optimum operating conditions via a Design of Experiments (DoE) approach. The use of a systematic optimization, together with the adaptability of 3D printed equipment to the process requirements, render the presented approach highly promising for a more feasible implementation of biocatalysts in continuous industrial processes.
A Phase I Clinical Trial to Assess Safety and Tolerability of Injectable Collagenase in Women with Symptomatic Uterine Fibroids
Authors: Singh Bhuchitra , Sims Holly , Trueheart Irene , Simpson Khara , Wang Karen C. , Patzkowsky Kristin , Wegman Thomas , Soma Jean-Marie , Dixon Rosina , Jayes Friederike , Voegltine Kristin , Yenokyan Gayane , Su Szu-Chi , Leppert Phyllis , Segars James H. 
Published: April 2021

AbstractUterine fibroids feature excessive deposition of types I and III collagen. Previous ex vivo studies showed an FDA-approved collagenase (EN3835)-digested types I and III collagen fibers in fibroid tissues; however, collagenase had not been evaluated in vivo for effects on uterine fibroids. The objective was to assess the safety and tolerability of collagenase injection directly into uterine fibroids. This was a prospective, open label, dose escalation study. The study participants were fifteen women aged 35–50 years with symptomatic uterine fibroids planning to undergo hysterectomy. Three subjects received saline and methylene blue, three subjects received a fixed dose of EN3835, and 9 subjects received stepped, increasing dosages of EN3835, all by transvaginal, ultrasound-guided injections. Primary outcome measures were safety and tolerability of the injection and change in collagen content between treated and control tissues. There were no significant adverse events following injection of EN3835 into uterine fibroids. Masson’s trichrome stains revealed a 39% reduction in collagen content in treated samples compared to controls (p <0.05). Second harmonic generation (SHG) analysis showed treated samples to have a 21% reduction in density of collagen compared to controls. Picrosirius-stained collagenase-treated fibroids showed collagen fibers to be shorter and less dense compared to controls. Subjects reported a decrease in fibroid-related pain on the McGill Pain Questionnaire after study drug injection in Group 2 at both 4–8 days and 60–90 days post-injection. The findings indicated that injection of collagenase was safe and well tolerated. These results support further clinical investigation of collagenase as a minimally invasive treatment of uterine fibroids. NCT0289848.
ASYMPTOTICS FOR SYSTEMIC RISK WITH DEPENDENT HEAVY-TAILED LOSSES
Authors: Liu Jiajun , Yang Yang 
Published: April 2021

AbstractSystemic risk (SR) is considered as the risk of collapse of an entire system, which has played a significant role in explaining the recent financial turmoils from the insurance and financial industries. We consider the asymptotic behavior of the SR for portfolio losses in the model allowing for heavy-tailed primary losses, which are equipped with a wide type of dependence structure. This risk model provides an ideal framework for addressing both heavy-tailedness and dependence. As some extensions, several simulation experiments are conducted, where an insurance application of the asymptotic characterization to the determination and approximation of related SR capital has been proposed, based on the SR measure.
Ahlfors regularity and fractal dimension of Smale spaces
Authors: GERONTOGIANNIS DIMITRIS MICHAIL 
Published: April 2021

AbstractWe prove that, up to topological conjugacy, every Smale space admits an Ahlfors regular Bowen measure. Bowen’s construction of Markov partitions implies that Smale spaces are factors of topological Markov chains. The latter are equipped with Parry’s measure, which is Ahlfors regular. By extending Bowen’s construction, we create a tool for transferring the Ahlfors regularity of the Parry measure down to the Bowen measure of the Smale space. An essential part of our method uses a refined notion of approximation graphs over compact metric spaces. Moreover, we obtain new estimates for the Hausdorff, box-counting and Assouad dimensions of a large class of Smale spaces.
Consultant psychiatrists’ experience of the impact of the COVID-19 pandemic on mental health services
Authors: Kelleher E. , Geary E. H. , Tawfik M. , Ní Mhuircheartaigh E. , Gavin B. , Wall M. , Lyne J. P. , Doherty A. M. , McNicholas F. 
Published: April 2021

Objectives:The novel coronavirus 2019 (COVID-19) has spread worldwide threatening human health. To reduce transmission, a ‘lockdown’ was introduced in Ireland between March and May 2020. The aim of this study is to capture the experiences of consultant psychiatrists during lockdown and their perception of it’s impact on mental health services.Methods:A questionnaire designed by the Royal College of Psychiatrists was adapted and circulated to consultant members of the College of Psychiatrists of Ireland following the easing of restrictions. The questionnaire assessed the perceived impact on referral rates, mental health act provision, availability of information technology (IT), consultant well-being and availability of personal protective equipment (PPE). Thematic analysis was employed to analyse free-text sections.Results:Response rate was 32% (n = 197/623). Consultants reported an initial decrease/significant decrease in referrals in the first month of lockdown (68%, n = 95/140) followed by an increase/significant increase in the second month for both new (83%, n = 100/137) and previously attending patients (65%, n = 88/136). Social isolation and reduced face-to-face mental health supports were among the main reasons identified. The needs of children and older adults were highlighted. Most consultants (76%, n = 98/129) felt their working day was affected and their well-being reduced (52%, n = 61/119). The majority felt IT equipment availability was inadequate (67%, n = 88/132). Main themes identified from free-text sections were service management, relationship between patients and healthcare service and effects on consultants’ lives.Conclusions:The COVID-19 pandemic has placed increased pressure on service provision and consultant wellness. This further supports the longstanding need to increase mental health service investment.
Sudden hearing loss and coronavirus disease 2019: the role of corticosteroid intra-tympanic injection in hearing improvement
Authors: Rahimi V , Asiyabar M K , Rouhbakhsh N 
Published: April 2021

AbstractBackgroundCoronavirus disease 2019 was first seen in December 2019. Due to the insidious and complex nature of the disease, the list of symptoms is rapidly expanding. So far, few studies have reported sudden sensorineural hearing loss as a possible symptom of coronavirus disease 2019.Case reportA 60-year-old woman with a complaint of sudden sensorineural hearing loss and subjective severe tinnitus presented to the ENT clinic. Coronavirus disease 2019 was subsequently confirmed with a polymerase chain reaction test. At the time of presentation, she was treated with intra-tympanic dexamethasone. Improvements in hearing threshold and speech perception, and a subjective reduction in tinnitus, were observed after treatment.ConclusionThis case report supports evidence from other case reports of a possible association between coronavirus disease 2019 and sudden sensorineural hearing loss. Sudden sensorineural hearing loss may be a symptom of this disease that behaves as an underlying aggravating factor. Intra-tympanic injection of corticosteroids is recommended for managing these patients during the pandemic.
TheSaikewiczDecision: A Medical Viewpoint
Authors: Relman Arnold S. 
Published: April 2021

AbstractIn this Article, Dr. Arnold S. Relman, the Editor ofThe New England Journal of Medicine,takes issue with the 1977Saikewiczdecision of the Massachusetts Supreme Judicial Court, which addressed the question of whether chemotherapy should be provided to a severely retarded 67-year-old man who had developed acute leukemia. Dr. Relman interpretsSaikewiczas requiring that medical treatment decisions involving the life or death of incompetent patients must receive judicial resolution instead of resolution by the patient's family and physicians. This rule, he asserts, violates medical tradition, and its application will result in serious problems, such as the unnecessary prolongation of the suffering of many seriously ill persons. Dr. Relman proposes, as an alternative to theSaikewiczapproach, that in such cases judicial resolution should occur only when there is disagreement, concerning treatment, among next of kin, or between next of kin and attending physicians, or when there is a complaint of injury or of wrongdoing. In all other situations, resolution solely by next of kin and attending physicians should be sufficient. Adequate protection of the interests of the incompetent patient could be achieved by a requirement that the physician in charge document in the medical record that the treatment decision received the concurrence of the family and advance approval of a group of the physician's professional colleagues who have no vested interest in the outcome of the decision.
Private Credentialing of Health Care Personnel: An Antitrust Perspective
Authors: Havighurst Clark C. , King Nancy M. P. 
Published: April 2021

AbstractHaving argued in Part One against extensive judicial or regulatory interference with private personnel credentialing in the health care field, this Article now shifts its focus to emphasize the anticompetitive hazards inherent in credentialing as practiced by professional interests. Competitor-sponsored credentialing is shown to be a vital part of a larger cartel strategy to curb competition by standardizing personnel and services and controlling the flow of information to health care consumers. Instead of altering the conclusions reached in Part One, however, Part Two sets forth a new and hitherto unexplored agenda for antitrust enforcement, one that the authors believe will increase the quantity and quality of information available to consumers and offer a fairer competitive environment to individuals and groups disadvantaged by the denial of desirable credentials. The specific targets singled out for antitrust scrutiny are (1) the practice of "grandfathering," by which new candidates for credentials are required to meet tougher requirements than were met by existing credential holders; (2) agreements to standardize educational programs if they go beyond setting and applying accrediting standards and impair the freedom of institutions to decide independently whether to offer unaccredited training; (3) agreements by which independent certifying or accrediting bodies limit the nature or scope of competition among themselves; and (4) mergers and joint ventures in credentialing and accrediting. The legal theory supporting antitrust attacks in the latter two categories is strengthened by the apparently original insight that commercial information and opinion are themselves articles of commerce such that agreements and combinations restricting their nature and output can be characterized as restraints of trade. Among the many self-regulatory institutions in the health care field whose operation or sponsorship is called into question by the analysis herein are the leading medical specialty boards, the Liaison Committee on Medical Education, various accrediting and certifying bodies in the allied health occupations, and the Joint Commission on Accreditation of Hospitals.
Atypical presentation of Neisseria meningitidis serogroup W disease is associated with the introduction of the 2013 strain
Authors: Säll Olof , Stenmark Bianca , Jacobsson Susanne , Eriksson Lorraine , Thulin Hedberg Sara , Hertting Olof , Fredlund Hans , Sundqvist Martin , Mölling Paula 
Published: April 2021

Abstract
Since 2015, the incidence of invasive meningococcal disease (IMD) caused by serogroup W (MenW) has increased in Sweden, due to the introduction of the 2013 strain belonging to clonal complex 11. The aim of this study was to describe the clinical presentation of MenW infections, in particular the 2013 strain, including genetic associations. Medical records of confirmed MenW IMD cases in Sweden during the years 1995–2019 (n = 113) were retrospectively reviewed and the clinical data analysed according to strain. Of all MenW patients, bacteraemia without the focus of infection was seen in 44%, bacteraemic pneumonia in 26%, meningitis in 13% and epiglottitis in 8%, gastrointestinal symptoms in 48% and 4% presented with petechiae. Phylogenetic analysis was used for possible links between genetic relationship and clinical picture. The 2013 strain infections, particularly in one cluster, were associated with more severe disease compared with other MenW infections. The patients with 2013 strain infections (n = 68) were older (52 years vs. 25 years for other strains), presented more often with diarrhoea as an atypical presentation (P = 0.045) and were more frequently admitted for intensive care (P = 0.032). There is a risk that the atypical clinical presentation of MenW infections, with predominantly gastrointestinal or respiratory symptoms rather than neck stiffness or petechiae, may lead to delay in life-saving treatment.