bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prototyping a collaborative data curation service for coastal science
Authors: Goldstein Evan B. , Braswell Anna E. , McShane Caitlin M. 
Published: September 2021

Abstract
The growing push for open data resulted in an abundance of data for coastal researchers, which can lead to problems for individual researchers related to data discoverability. One solution is to explicitly develop services for coastal researchers to help curate data for discovery, hosting discussions around reuse, community building, and finding collaborators. To develop the idea of a coastal data curation service, we investigate aspects of the UNESCO International Coastal Atlas Network member sites that could be used to build a curation service. We develop a minimal example of a coastal data curation service, deploy this as a website, and describe the next steps to move beyond the prototype phase. We envision a coastal data curation service as a way to cultivate a community focused on coastal data discovery and reuse.
ON THE SOCIAL AND COGNITIVE DIMENSIONS OF WICKED ENVIRONMENTAL PROBLEMS CHARACTERIZED BY CONCEPTUAL AND SOLUTION UNCERTAINTY
Authors: ARROYAVE FELBER J. , GOYENECHE OSCAR YANDY ROMERO , GORE MEREDITH , HEIMERIKS GASTON , JENKINS JEFFREY , PETERSEN ALEXANDER M. 
Published: September 2021

We develop a quantitative framework for understanding the class of wicked problems that emerge at the intersections of natural, social, and technological complex systems. Wicked problems reflect our incomplete understanding of interdependent global systems and the systemic risk they pose; such problems escape solutions because they are often ill-defined, and thus mis-identified and under-appreciated by communities of problem-solvers. While there are well-documented benefits to tackling boundary-crossing problems from various viewpoints, the integration of diverse approaches can nevertheless contribute confusion around the collective understanding of the core concepts and feasible solutions. We explore this paradox by analyzing the development of both scholarly (social) and topical (cognitive) communities — two facets of knowledge production studies here that contribute towards the evolution of knowledge in and around a problem, termed a knowledge trajectory — associated with three wicked problems: deforestation, invasive species, and wildlife trade. We posit that saturation in the dynamics of social and cognitive diversity growth is an indicator of reduced uncertainty in the evolution of the comprehensive knowledge trajectory emerging around each wicked problem. Informed by comprehensive bibliometric data capturing both social and cognitive dimensions of each problem domain, we thereby develop a framework that assesses the stability of knowledge trajectory dynamics as an indicator of wickedness associated with conceptual and solution uncertainty. As such, our results identify wildlife trade as a wicked problem that may be difficult to address given recent instability in its knowledge trajectory.
Wormholes solutions in f(R,T) gravity with photon sphere at the throat
Authors: Godani Nisha 
Published: September 2021

This work is aimed at the study of traversable wormholes, proposed by Morris and Thorne [Wormholes in spacetime and their use for interstellar travel: A tool for teaching general relativity, Am. J. Phys. 56 (1988) 395], in the framework of [Formula: see text] gravity, where [Formula: see text], [Formula: see text] and [Formula: see text] are constants. The wormhole solutions are obtained and analyzed by using a simplest form of shape function. Further, the existence of photon spheres outside the throat of wormhole due to the gravitational lensing effect is detected.
Association Between Impaired Myocardial Flow Reserve on
82
Rubidium Positron Emission Tomography Imaging and Adverse Events in Patients With Autoimmune Rheumatic Disease
Authors: Feher Attila , Boutagy Nabil E. , Oikonomou Evangelos K. , Liu Yi-Hwa , Miller Edward J. , Sinusas Albert J. , Hinchcliff Monique 
Published: September 2021

Background:
Coronary microvascular dysfunction has been described in patients with autoimmune rheumatic disease (ARD). However, it is unknown whether positron emission tomography (PET)-derived myocardial flow reserve (MFR) can predict adverse events in this population.

Methods:

Patients with ARD without coronary artery disease who underwent dynamic rest-stress
82
Rubidium PET were retrospectively studied and compared with patients without ARD matched for age, sex, and comorbidities. The association between MFR and a composite end point of mortality or myocardial infarction or heart failure admission was evaluated with time to event and Cox-regression analyses.

Results:
In 101 patients with ARD (88% female, age: 62±10 years), when compared with matched patients without ARD (n=101), global MFR was significantly reduced (median: 1.68 [interquartile range: 1.34–2.05] versus 1.86 [interquartile range: 1.58–2.28]) and reduced MFR (<1.5) was more frequent (40% versus 22%). MFR did not differ among subtypes of ARDs. In survival analysis, patients with ARD and low MFR (MFR<1.5) had decreased event-free survival for the combined end point, when compared with patients with and without ARD and normal MFR (MFR>1.5) and when compared with patients without ARD and low MFR, after adjustment for the nonlaboratory-based Framingham risk score, rest left ventricular ejection fraction, severe coronary calcification, and the presence of medium/large perfusion defects. In Cox-regression analysis, ARD diagnosis and reduced MFR were both independent predictors of adverse events along with congestive heart failure diagnosis and presence of medium/large stress perfusion defects on PET. Further analysis with inclusion of an interaction term between ARD and impaired MFR revealed no significant interaction effects between ARD and impaired MFR.

Conclusions:
In our retrospective cohort analysis, patients with ARD had significantly reduced PET MFR compared with age-, sex-, and comorbidity-matched patients without ARD. Reduced PET MFR and ARD diagnosis were both independent predictors of adverse outcomes.
PRMT5 Prevents Dilated Cardiomyopathy via Suppression of Protein O-GlcNAcylation
Authors: Li Zhenhua , Xu Jingping , Song Yao , Xin Chong , Liu Lantao , Hou Ning , Teng Yan , Cheng Xuan , Wang Tianle , Yu Zhenyang , Song Jiangping , Zhang Youyi , Wang Jian , Yang Xiao 
Published: September 2021

Rationale:
Protein O-GlcNAcylation is dynamically regulated by 2 key enzymes, OGT (O-GlcNAc transferase) and OGA (O-GlcNAcase). Excessive protein O-GlcNAcylation contributes to dilated cardiomyopathy (DCM), but its regulatory mechanisms are not fully understood. The PRMT5 (protein arginine methyltransferase 5) is the major type II arginine methyltransferase, which plays critical physiological roles by symmetrically dimethylating various downstream targets including proteins involved in RNA splicing. However, its function in regulating protein O-GlcNAcylation and DCM is unexplored.

Objective:
To elucidate the physiological function of PRMT5 and the mechanism underlying its role in regulating cardiac O-GlcNAcylation and homeostasis.

Methods and Results:

Conditional gene knockout was used to study the in vivo function of
PRMT5
in regulating cardiac homeostasis. An integrated analysis of transcriptomic and metabolomic profiles was performed to investigate the molecular mechanism. Adeno-associated virus 9-mediated gene delivery in the mouse was used to study the protein O-GlcNAcylation in
Prmt5
deficiency-induced DCM.
PRMT5
mRNA was decreased in human DCM hearts, and cardiomyocyte-specific
Prmt5
deletion in mice resulted in DCM and heart failure. Transcriptomic and metabolomic profiling identified increased O-GlcNAcylation in the hearts of
Prmt5
-knockout mice. Mechanistically,
Prmt5
deletion suppressed OGA expression by inhibiting the transcription of
Oga
and triggering its aberrant splicing. Consistently, a positive correlation of
PRMT5
and
OGA
was identified in human DCM hearts. Notably, gene therapy with adeno-associated virus 9 encoding the correctly spliced
Oga
normalized the cardiac protein O-GlcNAcylation levels and partially rescued the dilation and dysfunction of the hearts in
Prmt5
-knockout mice.

Conclusions:
Our data demonstrate a novel function of PRMT5 in regulating protein O-GlcNAcylation to maintain cardiac homeostasis, suggesting that targeting the PRMT5-OGA axis could be a potential strategy for treating DCM.
Doxycycline Combined With Bortezomib-Cyclophosphamide-Dexamethasone Chemotherapy for Newly Diagnosed Cardiac Light-Chain Amyloidosis: A Multicenter Randomized Controlled Trial
Authors: Shen Kai-ni , Fu Wei-jun , Wu Yu , Dong Yu-jun , Huang Zhong-xia , Wei Yong-qiang , Li Chun-rui , Sun Chun-yan , Chen Ye , Miao Hui-lei , Zhang Yue-lun , Cao Xin-xin , Zhou Dao-bin , Li Jian 
Published: September 2021

Background:
Doxycycline was demonstrated in a retrospective study to be associated with greater survival in patients with light chain amyloidosis. Therefore, we prospectively compared the efficacy of bortezomib-cyclophosphamide-dexamethasone (CyBorD) and CyBorD combined with doxycycline for cardiac light chain amyloidosis.

Methods:
This was a multicenter, open-label, randomized controlled trial. Patients with Mayo 2004 stage II to III light chain amyloidosis were included. Patients were randomized to doxycycline 100 mg twice daily along with 9 cycles of CyBorD (doxycycline group) or to 9 cycles of CyBorD alone (control group). The primary outcome was 2-year progression-free survival (PFS). PFS was defined as the time from randomization to death, hematologic progression, or organ progression (heart, kidney or liver). Hematologic progression was defined on the basis of a substantial increase in free light chain. An increase in either NT-proBNP (N-terminal pro B-type natriuretic peptide) or cardiac troponin was the main criterion for defining cardiac progression. Cardiac PFS, defined as the time from randomization to cardiac progression or death, was compared between groups in an exploratory analysis. The corresponding treatment hazard ratio was estimated with a Cox regression model.

Results:

One hundred forty patients underwent randomization, with 70 in each group. The median age was 61 years (range, 33–78 years) with a male:female ratio of 1.75:1. Stage II disease was present in 34 (48.6%) and 33 (47.1%) patients in the doxycycline and control groups, respectively. After a median follow-up duration of 24.4 months, 32 of 70 (45.7%) patients in the doxycycline group and 30 of 70 (42.9%) patients in the control group experienced progression. PFS was not significantly different between groups (hazard ratio, 0.97 [95% CI, 0.59–1.60];
P
=0.91). Cardiac progression occurred in 29 of 70 (41.4%) patients in the doxycycline group and 26 of 70 (37.1%) patients in the control group. The death rates for both groups by the end of follow-up was the same, 25 of 70 (35.7%). No significant differences were observed for either cardiac PFS (hazard ratio, 0.91 [95% CI, 0.54–1.55];
P
=0.74) or overall survival (hazard ratio, 1.04 [95% CI, 0.60–1.81];
P
=0.89).

Conclusions:
Our trial demonstrated that doxycycline combined with CyBorD failed to prolong PFS or cardiac PFS compared with CyBorD alone in cardiac light chain amyloidosis.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03401372.
A Handbook and Reader of Ottoman Arabic
Authors: Wagner Esther-Miriam 
Published: September 2021

Written forms of Arabic composed during the era of the Ottoman Empire present an immensely fruitful linguistic topic. Extant texts display a proximity to the vernacular that cannot be encountered in any other surviving historical Arabic material, and thus provide unprecedented access to Arabic language history.
This rich material remains very little explored. Traditionally, scholarship on Arabic has focussed overwhelmingly on the literature of the various Golden Ages between the 8th and 13th centuries, whereas texts from the 15th century onwards have often been viewed as corrupted and not worthy of study. The lack of interest in Ottoman Arabic culture and literacy left these sources almost completely neglected in university courses.
This volume is the first linguistic work to focus exclusively on varieties of Christian, Jewish and Muslim Arabic in the Ottoman Empire of the 15th to the 20th centuries, and present Ottoman Arabic material in a didactic and easily accessible way. Split into a Handbook and a Reader section, the book provides a historical introduction to Ottoman literacy, translation studies, vernacularisation processes, language policy and linguistic pluralism. The second part contains excerpts from more than forty sources, edited and translated by a diverse network of scholars.
The material presented includes a large number of yet unedited texts, such as Christian Arabic letters from the Prize Paper collections, mercantile correspondence and notebooks found in the Library of Gotha, and Garshuni texts from archives of Syriac patriarchs.
Comparison of mechanochemical ablation versus ligation and stripping for the treatment of incompetent small saphenous vein
Authors: Apruzzi Luca , Bilman Victor , Ardita Vincenzo , Favia Nicola , Saracino Concetta , Chiesa Roberto , Baccellieri Domenico 
Published: September 2021

Objective to compare the outcomes of mechanochemical ablation (MOCA) versus saphenopopliteal junction ligation and stripping (OS) for symptomatic small saphenous vein (SSV) insufficiency. Methods This is a retrospective study including symptomatic SSV patients treated with MOCA using the ClariVein catheter (Merit Medical, South Jordan, Utah, USA) or OS from 2015 to 2019. Results A total of 60 limbs (73.3% women, mean age 54.7 ± 14.4 years) were treated with MOCA and 58 limbs (63.8% women, mean age 54 ± 11.6 years) with OS. At 18 months follow-up, recurrence rates were 7.5% (4/53) for MOCA vs. 5.7% (3/52) for the OS group. MOCA group was associated with less pain at first postoperative day, and an early return to work (MOCA 3.5 ± 2.3 days vs. OS 14.2 ± 3.8 days, p < .0001). No cases of leg paresthesia/dysesthesia were observed in the MOCA group, while two patients (3.4%) presented neurological symptoms after OS treatment. Conclusion MOCA and OS are both safe and effective techniques for symptomatic SSV insufficiency. MOCA group demonstrated to be associated with less postoperative pain and early return to work compared to OS.
Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition
Authors: Saito Kaori , Zhang Qi , Yang Haeun , Yamatani Kotoko , Ai Tomohiko , Ruvolo Vivian , Baran Natalia , Cai Tianyu , Ma Helen , Jacamo Rodrigo , Kuruvilla Vinitha , Imoto Junichi , Kinjo Sonoko , Ikeo Kazuho , Moriya Kaori , Suzuki Koya , Miida Takashi , Kim Yong-Mi , Vellano Christopher P. , Andreeff Michael , Marszalek Joseph R. , Tabe Yoko , Konopleva Marina 
Published: September 2021

AbstractAcute myeloid leukemia (AML) cells are highly dependent on oxidative phosphorylation (OxPhos) for survival, and they continually adapt to fluctuations in nutrient and oxygen availability in the bone marrow (BM) microenvironment. We investigated how the BM microenvironment affects the response to OxPhos inhibition in AML by using a novel complex I OxPhos inhibitor, IACS-010759. Cellular adhesion, growth, and apoptosis assays, along with measurements of expression of mitochondrial DNA and generation of mitochondrial reactive oxygen species indicated that direct interactions with BM stromal cells triggered compensatory activation of mitochondrial respiration and resistance to OxPhos inhibition in AML cells. Mechanistically, inhibition of OxPhos induced transfer of mitochondria derived from mesenchymal stem cells (MSCs) to AML cells via tunneling nanotubes under direct-contact coculture conditions. Inhibition of OxPhos also induced mitochondrial fission and increased functional mitochondria and mitophagy in AML cells. Mitochondrial fission is known to enhance cell migration, so we used electron microscopy to observe mitochondrial transport to the leading edge of protrusions of AML cells migrating toward MSCs. We further demonstrated that cytarabine, a commonly used antileukemia agent, increased mitochondrial transfer of MSCs to AML cells triggered by OxPhos inhibition. Our findings indicate an important role of exogenous mitochondrial trafficking from BM stromal cells to AML cells as well as endogenous mitochondrial fission and mitophagy in the compensatory adaptation of leukemia cells to energetic stress in the BM microenvironment.
Mobility surveys beyond stated preference: introducing MyTrips, an SP-off-RP survey tool, and results of two case studies
Authors: Rudloff Christian , Straub Markus 
Published: September 2021

AbstractWhen introducing new mobility offers or measures to influence traffic, stated preference (SP) surveys are often used to assess their impact. In SP surveys, respondents do not answer questions about their actual behaviour, but about hypothetical settings. Therefore, answers are often biased. To minimise this hypothetical bias, so-called stated preference-off-revealed preference (SP-off-RP) surveys were developed. They base SP questions on respondents’ revealed behaviour and place unknown scenarios in a familiar context. Until now, this method was applied mostly to scenarios investigating the willingness to pay. The application to more complex mode or route choice problems, which require the calculation of routes, has not yet been done. In this paper, the MyTrips survey tool for the collection of SP-off-RP data based on respondents’ actual mobility behaviour is presented. SP questions are based on alternatives to typical routes of respondents, which are calculated on the fly with an intermodal router. MyTrips includes a larger survey and collects mobility diaries for one day representing respondents’ daily routine, calculates alternative routes and creates SP questions based on a Bayesian optimal design. Results from two case studies investigating behaviour changes are presented. The first case study investigated the extension of a subway line in Vienna, Austria. The second case study focused on the introduction of micro transit vehicles in a rural setting, replacing infrequent bus services. Results of the two case studies show a difference in response behaviour between SP and RP settings and suggest a reduction of hypothetical bias. For the latter study, a Latent Class SP-off-RP model was estimated. It shows that availability and accessibility of public transport are the main influences on the willingness to use it, independent of other household characteristics.
Medical cannabis authorization and the risk of cardiovascular events: a longitudinal cohort study
Authors: Zongo Arsene , Lee Cerina , Dyck Jason R. B. , El-Mourad Jihane , Hyshka Elaine , Hanlon John G. , Eurich Dean T. 
Published: September 2021

Abstract
Background
Cannabis is increasingly used for therapeutic purpose. However, its safety profile is not well known. This study assessed the risk of cardiovascular-related emergency department (ED) visit and hospitalization in adult patients authorized to use medical cannabis in Ontario, Canada from 2014 to 2017.

Methods
This is a longitudinal cohort study of patients who received medical cannabis authorization and followed-up in cannabis clinics, matched to population-based controls. The primary outcome was an ED visit or hospitalization for acute coronary syndrome (ACS) or stroke; and secondary outcome was for any cardiovascular event. Conditional Cox proportional hazards regression was used to assess the association between cannabis authorization and risk.

Results
18,653 cannabis patients were matched to 51,243 controls. During a median follow-up of 242 days, the incidence rates for ACS or stroke were 7.19/1000 person-years and 5.67/1000 person-years in the cannabis and controls group, respectively- adjusted hazard ratio (aHR) of 1.44 (95% CI 1.08–1.93). When stratified by sex, the association was only statistically significant among males: aHR 1.77 (1.23–2.56). For the secondary outcome (any CV events), the aHR was 1.47 (1.26–1.72). The aHR among males and females were 1.52 (1.24–1.86) and 1.41 (1.11–1.79), respectively. Tested interaction between cannabis authorization and sex was not significant (p > 0.05).

Conclusions
Medical cannabis authorization was associated with an increased risk of ED visits or hospitalization for CV events including stroke and ACS.
Distribution characteristics and influencing factors of homocyteine in an apparently healthy examined population
Authors: Bao Fang , Cui Ming , Shi Xiuying , Ju Shaoqing , Cong Hui 
Published: September 2021

Abstract
Background
Homocysteine (Hcy) is considered to be a risk factor for cardiovascular and cerebrovascular diseases. Few studies have evaluated the distribution of Hcy on a large-scale health examination. Accordingly, this study aimed to investigate the level and distribution of Hcy in the population with healthy physical examination and the correlation with other biomarkers, and analyzed for cardiovascular and other diseases.

Methods
Measurements of serum Hcy, TC, TG, LDL-c, HDL-c, ALT, ALP, γ-GT, TBIL, GLU, urea, Cr, UA, and related metabolic risk factors were selected for analysis from 8063 medical examination samples collected from February 2017 to April 2020. The relationship between Hcy and other biochemical indicators were evaluated with the multivariate regression model of age, gender, smoking, drinking, body mass index (BMI), systolic blood pressure (SBP), and diastolic blood pressure (DBP).

Results
Among 8063 cases, the age, BMI, SBP, and DBP of the high-Hcy group were higher than those of the low-Hcy group, the difference was statistically significant (P < 0.001), and the proportion of males, smoking, and drinking were higher than the low-Hcy group, the difference was statistically significant (P < 0.001); Hcy of the abnormal GLU group is higher than the normal GLU group (P = 0.002) and the Hcy of abnormal TG and HDL is higher than that of the normal blood lipid group (P < 0.001); Hcy of people with abnormal UA and Urea was higher than that of people with normal renal function (P < 0.001, P = 0.007). In multivariate analysis, lnHDL-C was negatively correlated with lnHcy (β = − 0.038, SE = 0.016, P = 0.019), lnCr was positively correlated with lnHcy (β = 0.055, SE = 0.016, P < 0.001), lnUA and lnHcy were positive correlated (β = 0.043, SE = 0.019, P = 0.022).

Conclusion
Hcy is closely related to HDL-c, Cr, and UA, which indicates that Hcy may affect the metabolism of HDL-c and UA, and can also be used as an auxiliary diagnostic index for kidney injury.