bluuebunny/crossref_metadata_2025_split huggingface dataset:
Renal protection in chronic heart failure: focus on sacubitril/valsartan
Authors: Pontremoli Roberto , Borghi Claudio , Perrone Filardi Pasquale 
Published: April 2021

Abstract
Chronic kidney disease (CKD) is highly prevalent in patients with chronic heart failure (CHF) and increases the risk of overall and cardiovascular (CV) mortality. Despite evidence supporting the effectiveness of angiotensin-converting enzyme inhibitors (ACE-Is), angiotensin receptor blockers, and mineralocorticoid receptor antagonists in decreasing mortality in patients with CHF, CKD hampers the optimization of standard pharmacologic therapy for heart failure. Therefore, other treatment options are needed to optimize treatment outcomes in CHF patients with CKD. The first-in-class angiotensin receptor-neprilysin inhibitor, sacubitril/valsartan, has a complementary activity that counteracts the potential unwanted long-term effects of over-activation of the renin–angiotensin–aldosterone system. Sacubitril/valsartan reduced the risk of CV mortality compared to standard therapy with an ACE-I in patients with heart failure with reduced ejection fraction (HFrEF) in the PARADIGM-HF trial and has been shown to be safe and effective in a broad range of HFrEF patients. However, data on the efficacy and tolerability of sacubitril/valsartan in patients with more advanced CKD are limited. This review discusses the evidence for the role of sacubitril/valsartan in providing additional renal benefit in patients with HFrEF. Data from clinical trials and real-world experience in patients with HFrEF and advanced CKD support the benefits of dual angiotensin/neprilysin inhibition across the breadth of kidney disease stages, including patients with significant renal impairment that was not reported in the pivotal PARADIGM-HF trial, and suggests a central role for the cardiac benefits of sacubitril/valsartan in nephroprotection.
Tax or green nudge? An experimental analysis of pesticide policies in Germany
Authors: Buchholz Matthias , Musshoff Oliver 
Published: April 2021

Abstract
We use a business management game to investigate how a pesticide tax and a green nudge affect crop, tillage and pesticide decisions for a virtual farm. Results from German farmers reveal that both policies can reduce pesticide applications. The pesticide tax involves a substantial profit loss. Unlike in the green nudge scenario, participants under pesticide tax adjust their cropping and tillage strategies. We compare farmers’ decisions to those made by a mathematical programming model. Assuming profit maximisation would overestimate farmers’ response to the tax and underestimate the effectiveness of the nudge.
Changes in smoking and alcohol consumption during COVID-19-related lockdown: a cross-sectional study in France
Authors: Guignard Romain , Andler Raphaël , Quatremère Guillemette , Pasquereau Anne , du Roscoät Enguerrand , Arwidson Pierre , Berlin Ivan , Nguyen-Thanh Viêt 
Published: April 2021

Abstract

Background
In many countries, lockdown measures were implemented to curb the COVID-19 pandemic. This situation may have an impact on mental health, tobacco smoking and alcohol consumption. The aim of this research report is therefore to describe changes in tobacco and alcohol consumption in the general French population during the first 2 weeks of lockdown and identify any associated factors.

Methods
Self-reported changes in smoking and alcohol consumption following the lockdown implemented in France on 17 March 2020 were collected from 2003 respondents aged 18 years and older in an online cross-sectional survey carried out from 30 March to 1 April 2020. Anxiety and depression levels were assessed using the Hospital Anxiety and Depression Scale.

Results
Among current smokers, 26.7% reported an increase in their tobacco consumption since lockdown and 18.6% reported a decrease, while it remained stable for 54.7%. The increase in tobacco consumption was associated with an age of 18–34 years, a high level of education, and anxiety. Among alcohol drinkers, 10.7% reported an increase in their alcohol consumption since lockdown and 24.4% reported a decrease, while it remained stable for 64.8%. The increase in alcohol consumption was associated with an age of 18–49 years, living in cities of more than 100 000 inhabitants, a high socio-professional category, and a depressive mood.

Conclusions
The national lockdown implemented in France during the COVID-19 pandemic influenced tobacco and alcohol consumption in different ways according to sociodemographic group and mental health.
Substrate specificities of α1,2- and α1,3-galactosyltransferases and characterization of Gmh1p and Otg1p in Schizosaccharomyces pombe
Authors: Fukunaga Takamasa , Tanaka Naotaka , Furumoto Toshio , Nakakita Shinichi , Ohashi Takao , Higuchi Yujiro , Maekawa Hiromi , Takegawa Kaoru 
Published: April 2021

Abstract
In the fission yeast Schizosaccharomyces pombe, α1,2- and α1,3-linked D-galactose (Gal) residues are transferred to N- and O-linked oligosaccharides of glycoproteins by galactosyltransferases. Although the galactomannans are important for cell–cell communication in S. pombe (e.g., in nonsexual aggregation), the mechanisms underlying galactosylation in cells remain unclear. Schizosaccharomyces pombe has 10 galactosyltransferase-related genes: seven belonging to glycosyltransferase (GT) family 34 and three belonging GT family 8. Disruption of all 10 α-galactosyltransferases (strain Δ10GalT) has been shown to result in a complete lack of α-Gal residues. Here, we have investigated the function and substrate specificities of galactosyltransferases in S pombe by using strains expressing single α-galactosyltransferases in the Δ10GalT background. High-performance liquid chromatography (HPLC) analysis of pyridylaminated O-linked oligosaccharides showed that two GT family 34 α1,2-galactosyltransferases (Gma12p and Gmh6p) and two GT family 8 α1,3-galactosyltransferases (Otg2p and Otg3p) are involved in galactosylation of O-linked oligosaccharide. Moreover, 1H-NMR of N-glycans revealed that three GT family 34 α1,2-galactosyltransferases (Gmh1p, Gmh2p and Gmh3p) are required for the galactosylation of N-linked oligosaccharides. Furthermore, HPLC and lectin-blot analysis revealed that Otg1p showed α1,3-galactosyltransferase activity under conditions of co-expression with Gmh6p, indicating that α-1,2-linked galactose is required for the galactosylation activity of Otg1p in S. pombe. In conclusion, eight galactosyltransferases have been shown to have activity in S. pombe with different substrate specificities. These findings will be useful for genetically tailoring the galactosylation of both N- and O-glycans in fission yeast.
Rawls and right-wing populism— A qualified defense of the former: A reply to Gila Stopler
Authors: Müller Jan-Werner 
Published: April 2021

Abstract
This reply to Gila Stopler’s provocative piece on the possible complicity of political liberalism and right-wing populism welcomes Stopler’s strategy of identifying structural weaknesses in liberal theory. But it also presents three specific disagreements: first, it is argued that Rawls is much less of a defender of the status quo in really existing liberal democracies than Stopler makes him out to be; second, the argument is advanced that political liberalism has significant resources to counter right-wing populism; and, third and most important, it is claimed, following the work of philosophers such as Gina Schouten, that political liberalism can (and must) incorporate feminist concerns.
In patients with multi-vessel coronary artery diseases, does hybrid revascularization provide similar outcomes to conventional coronary artery bypass grafting?
Authors: Maskell Perry , Graham Catherine , Roberts Lydia , Harky Amer 
Published: April 2021

Summary
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was: In [patients with multivessel coronary artery diseases (CAD)] is [hybrid revascularization (HCR)] equal to [coronary artery bypass grafting (CABG)] in regard to [mortality, myocardial infarction, stroke and target vessel revascularization (TVR)]? Three-hundred and fifty-five papers were found using the reported search, of which 8 represented the best evidence to answer the question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. The studies included 4 observational studies, 3 randomized controlled trials (RCTs) and 1 meta-analysis. The meta-analysis consisted of predominantly observational data with 1 randomized controlled trial and suggested non-significant differences in all major clinical outcomes. The observational studies generally cited benefit towards hybrid revascularization on the basis of equivalent major clinical outcomes rates compared to coronary artery bypass grafting, yet favourable in-hospital outcomes. One randomized controlled trial provided robust evidence of equivalent 5-year outcomes; however, the others were insufficiently powered for an effective comparison. There is a paucity of robustly designed studies to answer our clinical question effectively, given hybrid procedures are not routine in clinical practice. On the basis of mostly observational and small randomized cohorts with relatively short follow-up intervals, we conclude that current evidence suggests similar mid-term rates of major clinical outcomes after hybrid revascularization and coronary artery bypass grafting. However, without longer-term follow-up, the comparison of the two techniques, particularly relating to repeat revascularization, is still very much uncertain.
Free and Fair? The Differential Experiences of Voting Barriers and Voting Policies in American Midterm Elections
Authors: Foley Jordan M , Wagner Michael W , Hughes Ceri , Suk Jiyoun , Cramer Katherine J , Friedland Lewis A , Shah Dhavan V 
Published: April 2021

Abstract
In this research note, we provide evidence about burdens people face when voting and who benefits from policies designed to mitigate those burdens. Using pre-and-post 2018 midterm elections panel surveys in Wisconsin, we show that Black voters estimate greater time getting to the polls and Hispanic voters report longer wait times once they are there. Regarding who takes advantage of policies purported to ease these burdens on voting—early voting, voting by mail, and absentee voting—our analysis reveals that that those facing temporal disadvantages are not the groups benefiting from these electoral policy affordances.
Compassionate use of cefiderocol for carbapenem-resistant Acinetobacter baumannii prosthetic joint infection
Authors: Mabayoje Diana A , NicFhogartaigh Caoimhe , Cherian Benny P , Tan Mei Gie Meiqi , Wareham David W 
Published: April 2021

Abstract

Background
Cefiderocol is a recently licensed novel siderophore-conjugated cephalosporin stable to hydrolysis by serine and MBLs. It has been successfully used to treat Enterobacterales infections and is approved for the treatment of infections due to aerobic Gram-negative organisms in adults with limited treatment options.

Objectives
To describe the compassionate use of cefiderocol and clinical outcome in a case of prosthetic joint infection due to MDR Acinetobacter baumannii.

Patients and methods
This case study follows a 66-year-old woman who sustained an open fracture of the left distal humerus in Pakistan. She underwent open reduction and internal fixation and on return to the UK presented to hospital with a discharging surgical wound.

Results
Debridement of her wound cultured NDM carbapenemase-producing A. baumannii susceptible to colistin, tobramycin and tigecycline only. She developed vomiting with acute kidney injury with colistin and tigecycline. Antimicrobial efficacy of cefiderocol was predicted from in vitro and in vivo susceptibility tests. A successful request was made to Shionogi for compassionate use of cefiderocol, which was added to tigecycline. Cefiderocol was well tolerated with no toxicity and improved renal function. In total she received 25 days of cefiderocol and continued on tigecycline for a further 6 weeks in the community. She has well-healed wounds and good range of elbow movement.

Conclusions
Cefiderocol’s novel mode of cell entry is effective against MDR Gram-negative bacteria with reduced toxicity compared with other last line antibiotics. Our case demonstrates that cefiderocol may be useful as therapy for patients with limited treatment options due to antimicrobial resistance. The prescribing information for cefiderocol is available at: https://shionogi-eu-content.com/gb/fetcroja/pi.
Comparison of the Modified Centers for Disease Control and Prevention 2019-Novel Coronavirus Real-Time RT-PCR Method for Detection of Infectious and Heat-Inactivated Virus on Stainless Steel
Authors: Brunelle Sharon L , Bird Patrick M , Boone Jeremy , Nelson Maria , Johnson Zerlinde , Coates Scott 
Published: April 2021

Abstract

Background
Infectious Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) was used in the validation of methods for detection of SARS-CoV-2 on stainless-steel surfaces in the AOAC Research Institute Emergency Response Validation project. Handling infectious virus requires Biosafety Level (BSL)-3 facilities.

Objective
To compare the recovery and detection of infectious and heat-inactivated (HI; 65°C for 30 min) SARS-CoV-2 from stainless steel by the modified US Centers for Disease Control and Prevention (CDC) 2019-Novel Coronavirus (2019-nCoV) Real Time Reverse Transcription Polymerase Chain Reaction (RT-PCR) Diagnostic Panel.

Method
Viral stocks were diluted in viral transport medium (VTM) and deposited onto stainless-steel test areas at 2 × 103 and 2 × 104 genomic copies for low and high, respectively. Test areas were sampled and aliquots of the resulting test solutions analyzed by RT-qPCR according to the CDC method. Results were analyzed by probability of detection (POD) statistics.

Results
The low level, where fractional positive results (25–75%) are expected, yielded PODI = 0.80 (0.58, 0.92) for the infectious virus and PODHI = 0.15 (0.05, 0.36) for the HI virus. The bias, dPODHI = −0.65 (−0.80, −0.35), demonstrated a statistical difference between infectious and HI virus detection. No difference was observed at the high inoculation level.

Conclusions
Despite the statistical difference observed, the use of the HI virus is a viable alternative for matrix extension studies using a method comparison study design. Highlights: The use of HI SARS-CoV-2 can mitigate the need for a BSL-3 facility for matrix extension validation of alternative methods in SARS-CoV-2 studies.

Highlights
The use of HI SARS-CoV-2 can mitigate the need for a BSL-3 facility for matrix extension validation of alternative methods in SARS-CoV-2 studies.
The Semantics of Comparatives: A Difference-Based Approach
Authors: Zhang Linmin , Ling Jia 
Published: April 2021

AbstractDegree semantics has been developed to study how the meanings of measurement and comparison are encoded in natural language. Within degree semantics, this paper proposes a difference-based (or subtraction-based) approach to analyze the semantics of comparatives. The motivation is the measurability and comparability of differences involved in comparatives. The main claim is that comparatives encode a subtraction equation among three scalar values: two measurements along an interval scale and the difference between them. We contribute two innovations: (i) using interval arithmetic to implement subtraction, and (ii) analyzing comparative morpheme -er/more as an additive particle, denoting the default, most general, positive difference. Our analysis inherits existing insights in the literature. Moreover, the innovations bring new conceptual and empirical advantages. In particular, we address the interpretation of comparatives containing than-clause-internal quantifiers and various kinds of numerical differentials. We also account for three puzzles with regard to the scope island issue, the monotonicity of than-clauses, and the discourse status of the standard in comparison.
Chondroid tenosynovial giant cell tumour of the temporomandibular joint
Authors: Kanbour Abdullah , Hurrell Michael , Ricciardo Peter 
Published: April 2021

Abstract
Chondroid tenosynovial giant cell tumour (TGCT) is an extremely rare disease affecting the temporomandibular joint (TMJ). This report details the peri-operative findings and treatment with custom TMJ replacement of an initially misdiagnosed chondroid TGCT involving the TMJ.
A new species of Sakuraeolis from Mozambique, described using 3D reconstruction of anatomy and phylogenetic analysis
Authors: Ellis-Diamond Dawn C , Picton Bernard E , Tibiriçá Yara , Sigwart Julia D 
Published: April 2021

ABSTRACT
Here we describe a new species of shallow-subtidal nudibranch from south-eastern Africa. The strikingly vivid orange sea slug with white markings belongs to the long-disputed family Facelinidae, and has been photographed and recorded in the region by divers for some time. Tomographic modelling was applied to produce a 3D anatomical reconstruction of the reproductive and digestive organs from serial sections. A molecular phylogeny using multiple markers (cytochrome c oxidase subunit I, 16S rRNA and histone H3) recovered three distinct clades within the paraphyletic Facelinidae, in agreement with other recent studies. This topology supported a genus-level clade, including the type species of Sakuraeolis Baba, 1965, S. enosimensis Baba, 1930, the new species described herein, S. arcana n. sp., and an undescribed sibling species that shares morphological resemblance to S. arcana n. sp. Facelina quatrefagesi Vayssière, 1888 is also recognized as Caloria quatrefagesi n. comb. on the basis of molecular and morphology affinity. Field observations provided insight into phenology, with a population decline noted in August. Although the new species does not have the penial structure previously considered diagnostic for Sakuraeolis, the decision was made on the balance of evidence for phylogenetic affinity to amend the diagnosis of the genus to accommodate S. arcana n. sp.
Hiding behind the Veil of Action Fraud: The Police Response to Economic Crime in England and Wales and Evaluating the Case for Regionalization or a National Economic Crime Agency
Authors: Button Mark 
Published: April 2021

Abstract
This article explores the policing structures that emerged in the noughties in England and Wales to tackle economic crime, such as Action Fraud and the National Fraud Intelligence Bureau. This article reviews some of the growing literature on these structures, in-particular, two reports by Her Majesty’s Inspectorate of Constabulary, Fire and Rescue Services and a major investigation by the Police Foundation which provides a critical review of the police response to economic crime. This article argues the central problem is the lack of investigative capacity, among others. It also argues Action Fraud, which has become commonly derided, has become a useful veil from which the police to hide their inadequate response. This article argues radical change is required to address the investigative gap through either regionalization or a national solution, through a National Economic Crime Agency. This article considers some of the arguments for against such approaches and calls for a debate to commence on the future structures for policing economic crime.
Large-scale nuclear shell-model calculations of isotopes in the southwest region of 208Pb
Authors: Yoshinaga N , Yanase K , Watanabe C , Higashiyama K 
Published: April 2021

Abstract
Large-scale nuclear shell-model calculations are performed in the neutron- and proton-deficient Pt, Au, Hg, and Tl isotopes ($Z &lt; 82$ and $N \le 126$) near $^{208}$Pb. All the single-particle levels in the one-major shells, six neutron ($2p_{1/2}$, $1f_{5/2}$, $2p_{3/2}$, $0i_{13/2}$, $1f_{7/2}$, and $0h_{9/2}$) orbitals and five proton ($2s_{1/2}$, $1d_{3/2}$, $0h_{11/2}$, $1d_{5/2}$, and $0g_{7/2}$) orbitals are considered. For an effective two-body interaction, one set of the multipole pairing, quadrupole–quadrupole interactions is employed for all the nuclei considered. These phenomenological interactions are determined to reproduce the experimental energy spectra. Some of the isomeric states are analyzed in terms of the shell-model configurations. Octupole correlated states are discussed in terms of a collective octupole excitation on top of each shell model state.
Big Data in Finance
Authors: Goldstein Itay , Spatt Chester S , Ye Mao 
Published: April 2021

Abstract
Big data is revolutionizing the finance industry and has the potential to significantly shape future research in finance. This special issue contains papers following the 2019 NBER-RFS Conference on Big Data. In this introduction to the special issue, we define the “big data” phenomenon as a combination of three features: large size, high dimension, and complex structure. Using the papers in the special issue, we discuss how new research builds on these features to push the frontier on fundamental questions across areas in finance—including corporate finance, market microstructure, and asset pricing. Finally, we offer some thoughts for future research directions.
miR-936 is Increased in Schizophrenia and Inhibits Neural Development and AMPA Receptor-Mediated Synaptic Transmission
Authors: Panja Debabrata , Li You , Ward Michael E , Li Zheng 
Published: April 2021

Abstract
MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression and play important roles in the development and function of synapses. miR-936 is a primate-specific miRNA increased in the dorsolateral prefrontal cortex (DLPFC) of individuals with schizophrenia. The significance of miR-936 increase to schizophrenia is unknown. Here, we show that miR-936 in the human DLPFC is enriched in cortical layer 2/3 and expressed in glutamatergic and GABAergic neurons. miR-936 is increased from layers 2 to 6 of the DLPFC in schizophrenia samples. In neurons derived from human induced pluripotent stem cells (iNs), miR-936 reduces the number of excitatory synapses, inhibits AMPA receptor-mediated synaptic transmission, and increases intrinsic excitability. These effects are mediated by its target gene TMOD2. These results indicate that miR-936 restricts the number of synapses and the strength of glutamatergic synaptic transmission by inhibiting TMOD2 expression. miR-936 upregulation in the DLPFC, therefore, can reduce glutamatergic synapses and weaken excitatory synaptic transmission, which underlie the synaptic pathology and hypofrontality in schizophrenia.