bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shared genetic and environmental etiology between substance use disorders and suicidal behavior
Authors: Edwards Alexis C. , Ohlsson Henrik , Lannoy Séverine , Stephenson Mallory , Crump Casey , Sundquist Jan , Sundquist Kristina , Kendler Kenneth S. 
Published: November 2021

AbstractBackgroundPrevious studies have demonstrated substantial associations between substance use disorders (SUD) and suicidal behavior. The current study empirically assesses the extent to which shared genetic and/or environmental factors contribute to associations between alcohol use disorders (AUD) or drug use disorders (DUD) and suicidal behavior, including attempts and death.MethodsThe authors used Swedish national registry data, including medical, pharmacy, criminal, and death registrations, for a large cohort of twins, full siblings, and half siblings (N = 1 314 990) born 1960–1980 and followed through 2017. They conducted twin-sibling modeling of suicide attempt (SA) or suicide death (SD) with AUD and DUD to estimate genetic and environmental correlations between outcomes. Analyses were stratified by sex.ResultsGenetic correlations between SA and SUD ranged from rA = 0.60–0.88; corresponding shared environmental correlations were rC = 0.42–0.89 but accounted for little overall variance; and unique environmental correlations were rE = 0.42–0.57. When replacing attempt with SD, genetic and shared environmental correlations with AUD and DUD were comparable (rA = 0.48–0.72, rC = 0.92–1.00), but were attenuated for unique environmental factors (rE = −0.01 to 0.31).ConclusionsThese findings indicate that shared genetic and unique environmental factors contribute to comorbidity of suicidal behavior and SUD, in conjunction with previously reported causal associations. Thus, each outcome should be considered an indicator of risk for the others. Opportunities for joint prevention and intervention, while limited by the polygenic nature of these outcomes, may be feasible considering moderate environmental correlations between SA and SUD.
Old-age diversity is underrepresented in digital health research: findings from the evaluation of a mobile phone system for post-operative progress monitoring in Sweden
Authors: Poli Arianna , Kelfve Susanne , Berg Katarina , Motel-Klingebiel Andreas 
Published: November 2021

AbstractMuch research is conducted to evaluate digital-based solutions for health-care services, but little is known about how such evaluations acknowledge diversity in later life. This study helps fill this gap and analyses participation in the evaluation of a web-based mobile phone system for monitoring the post-operative progress of patients after day surgery. Participation is conceptualised as resulting from three processes: pre-screening, recruitment and self-selection. Based on field information and survey data, this study models (a) the (non-)participation in a sample of 498 individuals aged 60 and older that includes non-screened, non-recruited, decliners and participants in the evaluation, and (b) the individual decision to participate in a sample of 210 individuals aged 60 and older who were invited to take part in the evaluation. Increasing age enhances the likelihood of not being screened, not being recruited or declining the invitation. Those not recruited were most often ineligible because of technology-related barriers. Decliners and participants differed by age, gender, job, health status, digital skills, but not by social participation. Results suggest that highly specific groups of older people are more likely to be involved than others. Old-age diversity is not properly represented in digital health research, with implications for the inclusivity of new digital health technologies. This has implications for increased risks of old-age exclusion and exacerbation of social and digital inequalities in ageing societies.
Hydropower reservoir reduces Great Argus Argusianus argus density in proximity to its shore
Authors: ONG-IN TIWA , SAVINI TOMMASO 
Published: November 2021

Summary
Habitat degradation due to hydropower development within protected areas has a marked negative effect on resident wildlife species. However, efforts to develop appropriate conservation and management plans are hampered by a general lack of quantitative information and a poor understanding of relevant ecological constraints. Great Argus Argusianus argus, a large galliform species sensitive to habitat degradation, can reflect the impacts of the Chiew Larn reservoir in southern Thailand on local wildlife. Great Argus abundance in the remaining lowland areas of Khlong Saeng Wildlife Sanctuary (KSWS) was estimated using line transects along the Chiew Larn reservoir edges and in the forest interior between February and April 2017. The population estimate for KSWS was 108 individuals (95% CI: 41–272) based on the sampled area of 18.06 km2, with a density estimate of 5.9 calling males/km2. The abundance increased with increased distance from the reservoir shoreline, which might be related to the high level of direct and indirect human disturbance close to the hydropower reservoir.
Perception of pediatric oncology family care providers toward palliative care and its perceived barriers in Egypt
Authors: Mohamed Magda Aly , Ibrahim Ateya Megahed , Ibrahim Hanaa Mohamed , Abdella Nabila , Elmowafy Reda Ibrahim 
Published: November 2021

AbstractBackgroundPalliative care is comprehensive supportive care addressing the suffering, pain, discomfort, symptoms, and stress of cancer and any serious life-threatening disease. It is a key part of care for our children living with cancer and is an important source of support for their families. The study aimed to assess the perception of pediatric oncology family care providers toward palliative care and its perceived barriers in Egypt.MethodTotal number of 500 oncology children's family care providers was recruited. A descriptive research design was utilized. Researchers used three tools as Structured Interview Questionnaire to assess the participants' knowledge and perceived barriers, Attitude toward palliative care Likert Scale, and Reported Practices Observational Checklist. The study was conducted in outpatient cancer clinics affiliated with El-Nasr governmental hospital located at Port Said governorate.Results51.8% of the total oncology children's family care providers had sufficient knowledge, 78.6% had a positive attitude, while,76.8% of them had inappropriate Practice towards palliative care.Significance of resultsThe pediatric oncology family care providers had sufficient knowledge and a positive attitude toward palliative care, but their practices were inappropriate. Also, the majority of participants identified Lack of family care providers training in pediatric palliative care and improper communication between the health team and family care providers as the main barriers to providing palliative care to children. Providing a palliative care training program for family caregivers through continuing professional development is highly recommended besides further research studies using large probability samples at different settings.
Area‐Based Geocoding: An Approach to Exposure Assessment Incorporating Positional Uncertainty
Authors: Thompson Laura K. , Langholz Bryan , Goldberg Daniel W. , Wilson John P. , Ritz Beate , Tayour Carrie , Cockburn Myles 
Published: November 2021

AbstractWhile the spatial resolution of exposure surfaces has greatly improved, our ability to locate people in space remains a limiting factor in accurate exposure assessment. In this case‐control study, two approaches to geocoding participant locations were used to study the impact of geocoding uncertainty on the estimation of ambient pesticide exposure and breast cancer risk among women living in California's Central Valley. Residential and occupational histories were collected and geocoded using a traditional point‐based method along with a novel area‐based method. The standard approach to geocoding uses centroid points to represent all geocoded locations, and is unable to adapt exposure areas based on geocode quality, except through the exclusion of low‐certainty locations. In contrast, area‐based geocoding retains the complete area to which an address matched (the same area from which the centroid is returned), and therefore maintains the appropriate level of precision when it comes to assessing exposure by geography. Incorporating the total potential exposure area for each geocoded location resulted in different exposure classifications and resulting odds ratio estimates than estimates derived from the centroids of those same areas (using a traditional point‐based geocoder). The direction and magnitude of these differences varied by pesticide, but in all cases odds ratios differed by at least 6% and up to 35%. These findings demonstrate the importance of geocoding in exposure estimation and suggest it is important to consider geocode certainty and quality throughout exposure assessment, rather than simply using the best available point geocodes.
CMIP6 MultiModel Evaluation of Present‐Day Heatwave Attributes
Authors: Hirsch Annette L. , Ridder Nina N. , Perkins‐Kirkpatrick Sarah E. , Ukkola Anna 
Published: November 2021

AbstractHeatwave frequency, duration and intensity has increased since the 1950s, a trend likely to continue with anthropogenic climate change. Although climate model projections are an important source of information on how heatwaves and other climate extremes may evolve with climate change it is necessary to understand whether climate models are able to adequately reproduce historical statistics of these events. We provide the first global evaluation of CMIP6 models to characterize heatwave characteristics between 1950 and 2014. Further, we also include a global heatwave evaluation of the CMIP5 models, as no study currently exists. Our results demonstrate that both ensembles underestimate mean heatwave frequency with region‐dependent biases for mean heatwave duration, intensity, and cumulative heat. Comparisons between CMIP5 and CMIP6 show that improvements in skill for the heatwave metrics evaluated here are marginal, suggesting that future improvements in simulating heatwaves may only be possible with significant advances in climate modeling capabilities.
Disentangling Internal and External Contributions to Atlantic Multidecadal Variability Over the Past Millennium
Authors: Fang Shih‐Wei , Khodri Myriam , Timmreck Claudia , Zanchettin Davide , Jungclaus Johann 
Published: November 2021

AbstractThe Atlantic multidecadal variability (AMV) modulates the North Atlantic surface ocean variability and affects decadal climates over the globe; its underlying mechanisms remain, however, under debate. In this study, we use a multi‐model ensemble of transient past‐millennium (850–1849) and unperturbed preindustrial control simulations contributing to the paleoclimate modeling intercomparison project—phase 4 (PMIP4) to decompose the AMV signal into the internal AMV and the external signal. The internal component of AMV exhibits no robust behavior across simulations during periods of major forcing such as strong volcanic eruptions, whereas the external forced temperature responds to volcanic eruptions with an immediate radiative cooling followed, in some simulations, by a sequence of damped multidecadal oscillations. The internal component tightly relates with the Atlantic meridional overturning circulation (AMOC) and dominates the fluctuations of AMV; whereas the external signal has limited impacts on AMOC and explains ∼25% of the AMV variance over the past millennium.
Deformation and Sedimentary Responses to Top‐to‐North Shear Along the Range Front of the Big Bend of the Ailao Shan–Red River Shear Zone, SE Edge of the Tibetan Plateau, and Its Tectonic Implications
Authors: Wang E. , Fan C. , Su Z. 
Published: November 2021

AbstractUnderstanding the mountain–basin coupling relationship is fundamental to placing constraints on the tectonic evolution of the Ailao Shan mylonite shear zone, the key feature accommodating relative movement between the Tibetan Plateau and SE Asia, because a contemporary basin, namely Red River, bounds its middle segment on the northeast, along which the shear zone is bent from northwest–southeast to roughly east–west (The Big Bend). The basin comprises two units: the Mubang Breccia and the Lengdun Conglomerate of Early Oligocene and Late Oligocene–Early Miocene age, respectively. This study reveals evidence indicating that the Wubang Breccia marks a high‐strain zone, resulting from top‐to‐north shear (range‐front detachment (RFD), along which the mylonite on the footwall experienced northward bending in the form of creeping. Moreover, the Lengdun Conglomerate on the hanging wall was deposited as growth strata, overlying a thrust belt to the north. The latter marks the southern rim of the Yangtze block, composed of extensional fault blocks, whose northward displacement along the toe of the RFD was synchronized with the north–south extension across the Red River basin. The spatial and temporal relationships between the Red River basin and the Ailao Shan shear zone indicate that basin formation was controlled by the change in geometry of the shear zone. The Red River basin can be viewed as an extensional step‐over in the left‐lateral strike‐slip field, in which all sedimentary and deformation processes were controlled by the extension and subsequent topographic spreading, accommodated by the RFD. This indicates that the extensional crustal materials, including both Langdun Conglomerate and underlying extensional fault blocks, were all shed from the top of the Ailao Shan mylonite belt. The cause of bending of the shear zone is attributed to the northward movement of India with respect to South China and the bending process came to an end as the left‐lateral movement ceased.
Spatial Patterns and Sensitivity of Intermittent Stream Drying to Climate Variability
Authors: Moidu H. , Obedzinski M. , Carlson S. M. , Grantham T. E. 
Published: November 2021

AbstractIntermittent streams comprise much of the global river network, and are expected to become more prevalent with climate change. Characterizing the expansion and contraction of intermittency in stream networks, and understanding how sensitive these dynamics are to climatic variability, is critical for predicting the trajectory of hydrologic regimes in a changing climate. Here, we consider the spatial patterns of stream intermittency, focusing on wetted channel conditions at the end of the dry season, and identify land cover, physiographic, and climate variables that influence surface water presence and variability across years. We trained statistical models with wetted channel mapping data from 25 streams over 7 years to predict both the spatial and interannual variability of the wetted channel network. We then used the models to assess intermittent stream dynamics across the Russian River watershed in northern California, USA. We found that an average of 3.7% of the stream network was reliably dry, while 16.1% was reliably wet at the end of the dry season, with the remainder of the network exhibiting variability in wetted conditions in response to antecedent precipitation. Both climatic and landscape characteristics controlled the extent of the wetted network, particularly antecedent precipitation at seasonal and annual time scales, highlighting the role of hydrologic memory in this system. Given predictions of increased climate volatility, an improved understanding of the spatial patterns and stability of dry season conditions in intermittent streams can inform climate risk assessments and strategies for protecting biodiversity and the ecosystem services that intermittent streams support.
Fatty acid transport protein-5 (FATP5) deficiency enhances hepatocellular carcinoma progression and metastasis by reprogramming cellular energy metabolism and regulating the AMPK-mTOR signaling pathway
Authors: Wang Ming-Da , Wang Nan-Ya , Zhang Hui-Lu , Sun Li-Yang , Xu Qiu-Ran , Liang Lei , Li Chao , Huang Dong-Sheng , Zhu Hong , Yang Tian 
Published: November 2021

AbstractAberrant lipid metabolism is an essential feature of hepatocellular carcinoma (HCC). Fatty acid transport protein-5 (FATP5) is highly expressed in the liver and is involved in the fatty acid transport pathway. However, the potential role of FATP5 in the pathogenesis of HCC remains largely unknown. Herein, we showed that FATP5 was downregulated in HCC tissues and even much lower in vascular tumor thrombi. Low expression of FATP5 was correlated with multiple aggressive and invasive clinicopathological characteristics and contributed to tumor metastasis and a poor prognosis in HCC patients. FATP5 inhibited the epithelial–mesenchymal transition (EMT) process and suppressed HCC cell migration and invasion, while silencing FATP5 had the opposite effects. Mechanistically, knockdown of FATP5 promoted cellular glycolytic flux and ATP production, thus suppressing AMP-activated protein kinase (AMPK) and activating its downstream signaling mammalian target of rapamycin (mTOR) to support HCC progression and metastasis. Activation of AMPK using metformin reversed the EMT program and impaired the metastatic capacity of FATP5-depleted HCC cells. Collectively, FATP5 served as a novel suppressor of HCC progression and metastasis partly by regulating the AMPK/mTOR pathway in HCC, and targeting the FATP5-AMPK axis may be a promising therapeutic strategy for personalized HCC treatment.
CSNK2 in cancer: pathophysiology and translational applications
Authors: Strum Scott W. , Gyenis Laszlo , Litchfield David W. 
Published: November 2021

AbstractProtein kinase CSNK2 (CK2) is a pleiotropic serine/threonine kinase frequently dysregulated in solid and hematologic malignancies. To consolidate a wide range of biological and clinically oriented data from this unique kinase in cancer, this systematic review summarises existing knowledge from in vitro, in vivo and pre-clinical studies on CSNK2 across 24 different human cancer types. CSNK2 mRNA transcripts, protein levels and activity were found to be routinely upregulated in cancer, and commonly identified phosphotargets included AKT, STAT3, RELA, PTEN and TP53. Phenotypically, it frequently influenced evasion of apoptosis, enhancement of proliferation, cell invasion/metastasis and cell cycle control. Clinically, it held prognostic significance across 14 different cancers, and its inhibition in xenograft experiments resulted in a positive treatment response in 12. In conjunction with commentary on preliminary studies of CSNK2 inhibitors in humans, this review harmonises an extensive body of CSNK2 data in cancer and reinforces its emergence as an attractive target for cancer therapy. Continuing to investigate CSNK2 will be crucial to advancing our understanding of CSNK2 biology, and offers the promise of important new discoveries scientifically and clinically.
DACH1 inhibits breast cancer cell invasion and metastasis by down-regulating the transcription of matrix metalloproteinase 9
Authors: Aman Sattout , Li Yanan , Cheng Yunmeng , Yang Yuxi , Lv Linlin , Li Bowen , Xia Kangkai , Li Shujing , Wu Huijian 
Published: November 2021

AbstractHuman Dachshund homolog 1 (DACH1) is usually defined as a tumor suppressor, which plays an influential role in tumor growth and metastasis in a variety of cancer cells. However, the underlying mechanisms in these process are not yet fully clarified. In this study, DACH1 inhibited the invasion and metastasis of breast cancer cells by decreasing MMP9 expression. Mechanistically, DACH1 represses the transcriptional level of MMP9 by interacting with p65 and c-Jun at the NF-κB and AP-1 binding sites in MMP9 promoter respectively, and the association of DACH1 and p65 promote the recruitment of HDAC1 to the NF-κB binding site in MMP9 promoter, resulting in the reduction of the acetylation level and the transcriptional activity of p65. Accordingly, the level of MMP9 was decreased. In conclusion, we found a new mechanism that DACH1 could inhibit the metastasis of breast cancer cells by inhibiting the expression of MMP9.
EGR1 modulated LncRNA HNF1A-AS1 drives glioblastoma progression via miR-22-3p/ENO1 axis
Authors: Ma Chunchun , Wang Hongliang , Zong Gang , He Jie , Wang Yuyang , Yang Fan , Yang Zhihao , Bian Erbao , Zhao Bing 
Published: November 2021

AbstractAccumulating evidences revealed that long noncoding RNAs (lncRNAs) have been participated in cancer malignant progression, including glioblastoma multiforme (GBM). Despite much studies have found the precise biological role in the regulatory mechanisms of GBM, however the molecular mechanisms, particularly upstream mechanisms still need further elucidated. RT-QPCR, cell transfection, western blotting and bioinformatic analysis were executed to detect the expression of EGR1, HNF1A-AS1, miR-22-3p and ENO1 in GBM. Cell proliferation assay, colony formation assay, wound healing, migration and invasion assays were performed to detect the malignant characters of GBM cells. The molecular regulation mechanism was confirmed by luciferase reporter assay, ChIP and RIP. Finally, orthotopic mouse models were established to examine the effect of HNF1A-AS1 in vivo. In the current study, we analyzed clinical samples to show that the HNF1A-AS1 expression is upregulated and associated with poor patient survival in GBM. Functional studies revealed that HNF1A-AS1 knockdown markedly inhibits malignant phenotypes of GBM cells, whereas overexpression of HNF1A-AS1 exerts opposite effect. Mechanistically, the transcription factor EGR1 forced the HNF1A-AS1 expression by directly binding the promoter region of HNF1A-AS1. Furthermore, combined bioinformatics analysis with our mechanistic work, using luciferase reporter assays and RIP, we first demonstrated that HNF1A-AS1 functions as a competing endogenous RNA (ceRNA) with miR-22-3p to regulate ENO1 expression in GBM cells. HNF1A-AS1 directly binds to miR-22-3p and significantly inhibits miR-22-3p expression, while ENO1 expression was increased. miR-22-3p inhibitor offsets the HNF1A-AS1 silencing induced suppression in malignant behaviors of GBM cells. ENO1 was verified as a direct target of miR-22-3p and its expression levels was negatively with the prognosis in GBM patients. Taken together, our study illuminated the definite mechanism of HNF1A-AS1 in promoting GBM malignancy, and provided a novel therapeutic target for further clinical application.
In vitro and in silico characterization of adiponectin-receptor agonist dipeptides
Authors: Lee Yuna , Nakano Akihiro , Nakamura Saya , Sakai Kenta , Tanaka Mitsuru , Sanematsu Keisuke , Shigemura Noriatsu , Matsui Toshiro 
Published: November 2021

AbstractThe aim of this study is to develop a dipeptide showing an adiponectin receptor 1 (AdipoR1) agonistic effect in skeletal muscle L6 myotubes. Based on the structure of the AdipoR1 agonist, AdipoRon, 15 synthetic dipeptides were targeted to promote glucose uptake in L6 myotubes. Tyr-Pro showed a significant increase in glucose uptake among the dipeptides, while other dipeptides, including Pro-Tyr, failed to exert this effect. Tyr-Pro induces glucose transporter 4 (Glut4) expression in the plasma membrane, along with adenosine monophosphate-activated protein kinase (AMPK) activation. In AdipoR1-knocked down cells, the promotion by Tyr-Pro was ameliorated, indicating that Tyr-Pro may directly interact with AdipoR1 as an agonist, followed by the activation of AMPK/Glut4 translocation in L6 myotubes. Molecular dynamics simulations revealed that a Tyr-Pro molecule was stably positioned in the two potential binding pockets (sites 1 and 2) of the seven-transmembrane receptor, AdipoR1, anchored in a virtual 1-palmitoyl-2-oleoyl-phosphatidylcholine membrane. In conclusion, we demonstrated the antidiabetic function of the Tyr-Pro dipeptide as a possible AdipoR1 agonist.