bluuebunny/crossref_metadata_2025_split huggingface dataset:
Point-of-Care Testing in Out-of-Hospital Cardiac Arrest: A Retrospective Analysis of Relevance and Consequences
Authors: Gruebl Tobias , Ploeger Birgit , Wranze-Bielefeld Erich , Mueller Markus , Schmidbauer Willi , Kill Clemens , Betz Susanne 
Published: May 2021

Abstract
BackgroundMetabolic and electrolyte imbalances are some of the reversible causes of cardiac arrest and can be diagnosed even in the pre-hospital setting with a mobile analyser for point-of-care testing (POCT).MethodsWe conducted a retrospective observational study, which included analysing all pre-hospital resuscitations in the study region between October 2015 and December 2016. A mobile POCT analyser (Alere epoc®) was available at the scene of each resuscitation. We analysed the frequency of use of POCT, the incidence of pathological findings, the specific interventions based on POCT as well as every patient’s eventual outcome.ResultsN=263 pre-hospital resuscitations were included and in n=98 of them, the POCT analyser was used. Of these measurements, 64% were performed using venous blood and 36% using arterial blood. The results of POCT showed that 63% of tested patients had severe metabolic acidosis (pH<7.2+BE<-5mmol/l). Of these patients, 82% received buffering treatment with sodium bicarbonate. Potassium levels were markedly divergent normal (>6.0mmol/l / <2.5mmol/l) in 17% of tested patients and 14% of them received a potassium infusion. On average, the pre-hospital treatment time between arrival of the first emergency medical responders and the beginning of transport was 54 (+/- 20) min without POCT and 60 (+/- 17) min with POCT (p=0.07). Overall, 21% of patients survived to hospital discharge (POCT 30% vs no POCT 16%, p=0.01).Conclusions Using a POCT analyser in pre-hospital resuscitation allows rapid detection of pathological acid-base imbalances and potassium concentrations and often leads to specific interventions on scene and could improve the probability of survival.
The Peculiar Hydrology of West-Central Florida’s Sandhill Wetlands, Ponds, and Lakes – Part 2: Hydrogeologic Controls
Authors: Nowicki ReNae S , Rains Mark C , LaRoche Jason J , Downs Christine M , Kruse Sarah E 
Published: May 2021

Abstract
This study investigates hydrogeologic controls on a peculiar, poorly studied type of geographically isolated wetland in west-central Florida, USA, locally referred to as “sandhill wetlands.” Their peculiarity lies in their connectivity to a large, regional aquifer, which controls their hydrology and influences their ecological expression. Six wetlands and one wetland-pond complex were examined using geophysical, lithologic, hydrologic, and ecological data. These data were used to configure site-specific hydrogeology, from which two conceptual models were developed. The first model depicts mechanisms of sandhill wetland connectivity to the regional aquifer. Three mechanisms of connectivity are proposed based on the degree and depth of aquifer confinement: 1) direct - due to wetland embedment directly in the unconfined regional aquifer; 2) indirect - due to embedment in a surficial aquifer, where groundwater exchange with the regional aquifer occurs through breaches in the semi-confining unit; and 3) none - due to embedment in a surficial aquifer where groundwater exchange with the regional aquifer does not occur because the semi-confining unit is too deep. The second model conceptualizes fundamental sandhill wetland ecohydrology. It depicts how the geomorphology of a sandhill depression relative to the range of the regional water table determine whether that feature will manifest as a wetland or as a pond, lake, sink, or upland. Findings from both models contribute to the limited understanding of sandhill wetland, pond, and lake ecohydrology and may be used to improve how they are classified, assessed, managed, and preserved as valuable natural resources.
Mediational Links for the Severity of Anorexia and Bulimia a Path Analysis Study
Authors: Ortiz Geovanny Genaro Reivan , Perez Roser Granero , Rodas Patricia Ortiz 
Published: May 2021

Abstract
Background: to date there is empirical evidence on the associations between anorexia and bulimia nervosa with psychopathological constructs (anxiety, depression, perfectionism, emotional dysregulation) and sociodemographic characteristics (gender and place of origin). However, there are no studies that analyze the underlying mechanisms between these variables, which allow estimating the direct and indirect effects, including the possible mediational relationships in causal models of path analysis. Method: the study had a sample of 918 Ecuadorian university students from three places of origin. Results: The causal path analysis model indicates a significant and positive association between the variables depending on the place of origin of the participants. Likewise, the model obtained an adequate goodness of fit and good predictive capacity. Conclusions: The data suggest that the model of underlying relationships between the study variables for the risk of ED, anorexia nervosa and bulimia nervosa, is different depending on the place of origin. It is indicated for future studies to estimate the criterion in the clinical population and with repetitive measures over time. We believe that the study will provide a starting point in the design, implementation and evaluation of prevention programs for eating disorders at the primary action levels.
Clinical Predictors of Definitive Treatment Interruptions of Long-course Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer
Authors: Sapienza Lucas Gomes , Raychaudhuri Sreejata , Nahlawi Suraya Khaled , Ozeir Serene , Abu-Isa Eyad 
Published: May 2021

Abstract
Background: This study aims to identify predictors of definitive treatment interruptions (DTI) of the neoadjuvant long-course radiotherapy (LCRT) in locally advanced rectal cancer (LARC), as well as determine their impact on clinical outcomes.Methods: Patients with stage II-III LARC treated between 2009-2018 were retrospectively analyzed (n=101). Logistic regression models were performed to evaluate the impact of relevant clinical variables on grade 3 or greater (G3+) acute toxicity, definitive treatment interruption (DTI), pathological complete response (pCR), and definitive ostomy (dOST) rates. The secondary outcomes were loco-regional control (LRC), metastasis-free survival (MFS), progression-free survival (PFS), cancer-specific survival (CSS) and overall survival (OS).Results: The incidences of grade 3 and 4 toxicities were 25.3%, and 1.1%, respectively. Most common G3+ toxicity were peri-anal dermatitis (14.7%) and diarrhea (7.4%), which were more frequent in females (p=0.040) and patients with tumor closer to the anal verge (p=0.019). Eleven cases (10.9%) developed DTI, which were associated with these G3+ events (p<0.001). Resection occurred after a median 7.1 weeks (IQR: 6.1-8.9). Downstaging occurred in 57.4% (including 17.8% pCR), 88% achieved negative margins and the dOST rate was 56.4%. After 49.5 months median follow-up, the 5-year LRC, MFS, PFS, CSS and OS were: 94.4%, 78.9%, 74.7%, 85.2% and 81.6%, respectively. DTI events did not impact pCR (p=0.435), dOST (p=0.611) or any survival outcomes. The only factors associated with loco-regional failure were close/positive margins (p<0.001) and pathologic stage ypIII (p=0.002).Conclusions: Tumors close to the anal verge and female sex were associated with increased G3+ toxicity, which was predictive of DTI. The resultant partial or complete omission of the planned boost, however, dose did not increase the chance of local recurrence. Further studies to clarify the benefit and the best timing to deliver the boost are warranted, especially for the patients with positive margins.
Predicting Patient Participation to an ICU Follow-Up Program
Authors: Prevedello Danielle , Steckelmacher Claire , Devroey Marianne , Creteur Jacques , Preiser Jean-Charles 
Published: May 2021

Abstract
Objective: Survivors of intensive care often present long-term sequelae, including cognitive impairment and psychological discomfort. Follow-up programs have therefore been developed to assess and manage these long-term complications. Studying the effectiveness of such programs can be limited by the number of patients lost during follow-up. The aim of this study was therefore to evaluate patient characteristics predictive of participation to an intensive care unit (ICU) follow-up program. Design: In this prospective, nested, case-control study, all patients with an ICU stay of at least five days were invited to participate in an ICU follow-up program. Having attended 2 follow-up sessions at ICU and hospital discharge, they were given an appointment for their 3-month follow up. Patients were divided into two groups (“participants and “non-participants”) according to whether or not they attended this appointment. Multivariable logistic regression analysis was used to identify independent predictors of participation.Settings: An ICU follow-up program from a mixed ICU at a university hospital.Participants: All patients selected to participate to the ICU follow-up program were included in this study. They were allocated into two groups depending on their attendance in the follow-up program. Intervention: NoneMain results: Of the 199 patients included during the study period, 80 (40.2%) were classified as “participants”. These patients had a lower Charlson Comorbidity Index, a longer ICU length of stay (LOS), more frequently received ventilatory support for at least 24 hours and more frequently received extracorporeal membrane oxygenation (ECMO) than non-participant patients. In the multivariable analysis, ICU LOS longer than 10 days was associated with a 3.3 times increased likelihood of participating in the follow-up; a lower Charlson Comorbidity Index also predicted an increased likelihood of participating to the ICU follow-up clinic.Conclusions: Fewer comorbidities and longer intensive care LOS were independent predictors of participation in ICU follow-up.
A Novel Protein AoHPS1 Is Involved In Oxidative Stress and Kojic Acid Synthesis in Aspergillus Oryzae
Authors: Li Yuzhen , Zhang Huanxin , Chen Ziming , Fan Junxia , Chen Tianming , Zeng Bin , Zhang Zhe 
Published: May 2021

Abstract
Aspergillus oryzae usually suffers from oxidative stress during the process of aerobic fermentation. However, there is little information on what genes involve in oxidative stress of A. oryzae. Here, we found that the expression of a novel gene Aohps1 was induced during the growth and development of A. oryzae with and without oxidative stress. Sequence analysis revealed that Aohps1 has four transmembrane regions and is conserved in Aspergillus species. Overexpression and deletion of Aohpi1 caused the growth defects with and without oxidative stress, including mycelium growth, conidia formation and biomass. Meanwhile, the Aohpi1 overexpression strain exhibited more sensitivity to oxidative stress than the Aohpi1 disrupted mutant. Furthermore, overexpression and disruption of Aohps1 resulted in the inhibition of kojic acid production with and without oxidative stress, consistent with the reduced expression of kojA that directly contributed to the synthesis of kojic acid. Additionally, the yield of kojic acid is less in the Aohps1 overexpression strain than in the Aohps1 deletion mutant under oxidative stress. Collectively, the discovery of Aohps1 provides new insights into oxidative stress and kojic acid synthesis in A. oryzae.
Quantum Optic Entanglement Using Graphene Clad Surface Plasmonic Polariton Device
Authors: Sahu Partha Pratim 
Published: May 2021

Abstract
Here, Graphene clad plasmonics waveguide is introduced as a two surface plasmonic polariton modes interference (GTSPPMI) coupler to obtain optically manipulated quantum interference. The manipulation of Handel Ou Handel (HOM) quantum interference is demonstrated theoretically in nano-scale two modes coupler through refractive index modulation in Graphene clad with incidence of an ultra fast optical pulse energy. The quantum entanglement of fidelity ~ 97.5% is obtained by incidence of optical pulse of energy 5.12 pJ and width 3.8 ps in Graphene cladding. Our results promise to obtain fast and compact optical reconfiguring of quantum plasmonics circuit in comparison to electrooptic and themooptic coupler.
Predictors of the Relationship Between the Duration of Cancer and Care Time With the Supportive Care Needs of Patients and the Quality of Life of Their Caregivers: A Path Analysis
Authors: Attari Seyedeh Maryam , mahmoodi Zohreh , Nimekari Mozhgan Mohammadzadeh , Nasiri Malihe , taziani Yaghoub Ashouri , Ozgoli Giti 
Published: May 2021

Abstract
Background: Breast cancer patients face various material, physical and psychological problems. The growing trend of breast cancer in Iran, the referral of patients in the advanced stages of the disease, and the mutual impact of patients and caregivers on each other show the need for further supportive care from the community and family. This study aimed to identify the predictors of the direct and indirect relationships of the duration of cancer and care time with the supportive needs of the patients and the quality of life of their family caregivers.Methods: This descriptive-analytical study was carried out on 150 patients and their caregivers in Iran. Data were collected using the Supportive Care Needs Survey-short form (SCNS-SF34), the Caregiver Quality of Life Index-Cancer (CQOLC) scale, and a socio-demographic checklist and were then analyzed in SPSS-24 and Lisrel-8.8 software using descriptive-analytical statistics and path analysis.Results: The mean age of the patients and caregivers was 45.76±10.44 and 43.46±9.5, respectively. Based on the test results, the duration of cancer was positively correlated with the total score of supportive needs in both paths (B=0.799). The patients’ sexuality needs had the highest negative correlation with their duration of cancer in the direct path (B=-0.87) and psychological needs the highest negative correlation in the indirect path (B=-0.32). The care time (in hours) had the highest positive correlation with the total score of supportive needs (B=15.6) in both the direct and indirect paths, and the highest positive correlation with physical needs in the direct path (B=10.65). The caregivers’ quality of life had a negative and direct relationship with the duration of cancer (B =-0.27) and there was a positive and direct relationship between care time and the caregivers’ quality of life (B=3.09). Conclusions: Duration of cancer and care time had the highest positive correlation with the patients’ supportive needs, and the caregivers’ quality of life had a negative correlation with the duration of cancer and a positive correlation with care time. It is therefore vital to emphasize the design and implementation of supportive care programs for breast cancer patients and their family caregivers.
Establishment of a Diagnostic Model to Distinguish Coronavirus Disease 2019 From Influenza a Based on Laboratory Findings
Authors: Xing Dongyang , Tian Suyan , Chen Yukun , Wang Jinmei , Sun Xuejuan , Li Shanji , Xu Jiancheng 
Published: May 2021

Abstract
BackgroundCoronavirus disease 2019 (COVID-19) and Influenza A are common disease caused by viral infection. The clinical symptoms and transmission routes of the two diseases are similar. This study established a model of laboratory findings to distinguish COVID-19 from influenza A perfectly. MethodsIn this study, 56 COVID-19 patients and 54 influenza A patients were included. Laboratory findings, epidemiological characteristics and demographic data were obtained from electronic medical record databases. Elastic network models, followed by a stepwise logistic regression model were implemented to identify indicators capable of discriminating COVID-19 and influenza A. ResultsA monogram is diagramed to show the resulting discriminative model. The majority of hematological and biochemical parameters in COVID-19 patients were significantly different from those in influenza A patients. In the final model, albumin/globulin, total bilirubin and erythrocyte specific volume were selected as predictors. This model has been demonstrated to have a satisfactory predictive performance to discriminate between COVID-19 and influenza A (AUC=0.844) using an external validation set. Conclusion﻿The establishment of a diagnostic model on laboratory findings is of great significance for the identification of COVID-19 and influenza A.
Effect of zinc supplementation on renal and sexual function of men with diabetic nephropathy and impotence, a randomized double-blind cross over clinical trial
Authors: Sharifi Faranak , Shajari Zahra , Feizy A.Amir 
Published: May 2021

Abstract
Background: Free radical generation and oxidative stress has been hypothesized to be underlying pathogenesis of diabetic complications like nephropathy and erectal dysfunction. Zinc can reduce lipid per-oxidation and improves endothelial functions. The aim of this study was to evaluate the effects of Zinc on renal and sexual function of men with Type 2 diabetes.Methods:This study has been supported financially by Zanjan University of Medical Sciences and registered in Iranian registry of clinical trials (www.irct.ir) with this code: IRCT138806091179N3.Fifty adult type 2 diabetic men with diabetic nephropathy and erectal dysfunction were enrolled in double-blind, randomized trial. Twenty-five patients received 30 mg Zinc-sulfate per day and the remaining subjects received placebo for three months. Baseline and end-study body mass index (BMI), blood pressure (BP), fasting plasma glucose (FPG), HbA1C, lipid profiles, serum creatinine (Cr), testosterone and zinc concentrations were measured. Albumin/creatinin ratio (ACR) and glumerular filtration rate (GFR) were calculated for all the participants. Sexual dysfunction was determined with International Index for Erectile Dysfunction questionnaire (IIEF-5).Results:Slight non-significant reduction versus a minimal non-significant increase in mean of ACR was seen with Zinc supplementation and placebo respectively (-3.7 ± 17.1 µg/mg vs. 2.8 ± 21.4 µg/mg; P= 0.130. Additionally Zinc supplementation had no effect on GFR and also erectile dysfunction of diabetic patients. However, significant improvement in FPG, HbA1c, total cholesterol and HDL-cholesterol concentration were seen with zinc supplementation (p:0.03). Conclusion: The results suggest that albuminuria, GFR and erectile function of men with type 2 DM cannot be affected by Zinc supplementation in dose of 30mg/day. Further studies in a larger population may be warranted.
Structural Changes in Proteins With Post-translational Modifications in Female Oncopathologies
Authors: Tikhonov Dmitry , Kulikova Liudmila , Kopylov Arthur T. , Rudnev Vladimir , Stepanov Alexander , Malsagova Kristina , Izotov Alexander , Kulikov Dmitry , Zulkarnaev Alexey , Enikeev Dmitry , Potoldykova Natalia , Kaysheva Anna L. 
Published: May 2021

Abstract
Post-translational processing leads to conformational changes in protein structure that modulate molecular functions and change the signature of metabolic transformations and immune responses. Some post-translational modifications (PTMs), such as phosphorylation and acetylation, are strongly related to oncogenic processes and malignancy. This study investigated a PTM pattern in patients with gender-specific ovarian or breast cancer. Proteomic profiling and analysis of cancer-specific PTM patterns were performed using high-resolution UPLC-MS/MS. Structural analysis, topology, and stability of PTMs associated with sex-specific cancers were analyzed using molecular dynamics modeling. We identified highly specific PTMs, of which 12 modified peptides from eight distinct proteins derived from patients with ovarian cancer and 6 peptides of three proteins favored patients from the group with breast cancer. We found that all defined PTMs were localized in the compact and stable structural motifs exposed outside the solvent environment. PTMs increase the solvent-accessible surface area of the modified moiety and its active environment. The observed conformational changes are still inadequate to activate the structural degradation and enhance protein elimination/clearance; however, it is sufficient for the significant modulation of protein activity.
The Role of Patient Navigators in Ambulatory Care: Overview of Systematic Reviews
Authors: Budde Hannah , Williams Gemma , Winkelmann Juliane , Pfirter Laura , Maier Claudia Bettina 
Published: May 2021

Abstract
Background: Patient navigators have been introduced across various countries to enable timely access to healthcare services and ensure completion of diagnosis and follow-up of care. There is an increasing amount of evidence on the positive effect of patient navigation for patients. The aim of this study was to analyse the evidence on patient navigation interventions in ambulatory care and to evaluate their effects on individuals and health system outcomes.Methods: An overview of reviews was conducted, based on a prespecified protocol. All patients in ambulatory care or transitional care setting were included in this review as long as it was related to the role of patient navigators. The study analysed all roles of patient navigators covering a wide range of health professionals such as physicians, nurses, pharmacists, social workers as well as lay health workers or community-based workers with no or very limited training. Studies including patient-related measures and health system-related outcomes were eligible for inclusion. A rigorous data collection was performed in multiple data bases. After reaching an inter-rater agreement, title and abstract screening was independently performed. Of an initial 8362 search results a total of 673 articles were eligible for full-text screening. An extraction form was used to analyse the nine included review.Results: Nine systematic reviews were included covering various patient navigation roles in cancer care, disease screening and transitional care. Seven systematic reviews primarily tailored services to ethnic minorities or other disadvantaged groups. Patient navigators performed tasks such as providing education and counselling, translations, home visits, outreach, scheduling of appointments and follow-up. Six reviews identified positive outcomes in expanding access to care, in particular for vulnerable patient groups. Two reviews on patient navigation in transitional care reported improved patient outcomes and hospital readmission rates and mixed evidence on quality of life and emergency department visits.Conclusions: Patient navigators have shown to expand access to screenings and health services for vulnerable patients or population groups who tend to underuse health services.