bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Integrated Droplet Manipulation Platform with Photodeformable Microfluidic Channels
Authors: Liu Quan , Yu Guodong , Zhu Chongyu , Peng Bo , Li Ruohan , Yi Tao , Yu Yanlei 
Published: November 2021

AbstractManipulating droplets by light in microscale allows precise control of microfluidics, liquid delivery, micromachines, and so on. Among these applications, microfluidic technology is of particular interest for miniaturization of the portable analysis systems, which require the integration of various liquid operations in one device. Here, a photodeformable microfluidic platform is constructed by combining Laplace pressure and capillary condensation to integrate the transportation, fusion, separation, and mixing of liquid slugs in one chip. The Laplace pressure, attributed to the photodeformation of the liquid crystal polymers, is generated to propel the slug. The capillary condensation is introduced by the delicate design of the fluid channels, allowing the fusion and separation of slugs without any connected microvalves. Catalytic oxidation reaction and protein detection processes are realized in the platform, which are amenable to a variety of miniaturized bio‐medical applications, such as portable analysis and point of care testing.
Genomic prediction of preliminary yield trials in chickpea: Effect of functional annotation of SNPs and environment
Authors: Li Yongle , Ruperao Pradeep , Batley Jacqueline , Edwards David , Martin William , Hobson Kristy , Sutton Tim 
Published: November 2021

AbstractAchieving yield potential in chickpea (Cicer arietinumL.) is limited by many constraints that include biotic and abiotic stresses. Combining next‐generation sequencing technology with advanced statistical modeling has the potential to increase genetic gain efficiently. Whole genome resequencing data was obtained from 315 advanced chickpea breeding lines from the Australian chickpea breeding program resulting in more than 298,000 single nucleotide polymorphisms (SNPs) discovered. Analysis of population structure revealed a distinct group of breeding lines with many alleles that are absent from recently released Australian cultivars. Genome‐wide association studies (GWAS) using these Australian breeding lines identified 20 SNPs significantly associated with grain yield in multiple field environments. A reduced level of nucleotide diversity and extended linkage disequilibrium suggested that some regions in these chickpea genomes may have been through selective breeding for yield or other traits. A large introgression segment that introduced fromC. echinospermumfor phytophthora root rot resistance was identified on chromosome 6, yet it also has unintended consequences of reducing yield due to linkage drag. We further investigated the effect of genotype by environment interaction on genomic prediction of yield. We found that the training set had better prediction accuracy when phenotyped under conditions relevant to the targeted environments. We also investigated the effect of SNP functional annotation on prediction accuracy using different subsets of SNPs based on their genomic locations: regulatory regions, exome, and alternative splice sites. Compared with the whole SNP dataset, a subset of SNPs did not significantly decrease prediction accuracy for grain yield despite consisting of a smaller number of SNPs.
Molecular detection and antibiotyping of multi‐drug resistant Enterococcus faecium from healthy broiler chickens in Bangladesh
Authors: Roy Krishna , Islam Md. Saiful , Paul Anamika , Ievy Samina , Talukder Mithun , Sobur Md. Abdus , Ballah Fatimah Muhammad , Khan Md. Shahidur Rahman , Rahman Md. Tanvir 
Published: November 2021

AbstractBackgroundEnterococcus faecium is a ubiquitously distributed member of the intestinal microbiota of both humans and animals. Antibiotic resistant E. faecium are a major public health concern.ObjectivesThis study aimed to detect multi‐drug resistant (MDR) E. faecium and their antibiotic resistance genes from broiler chickens in Bangladesh.MethodsA total of 100 faecal samples of healthy broilers were screened by conventional methods and polymerase chain reaction (PCR) to detect E. faecium and their resistance genes. Disk diffusion test was employed to determine antibiotic profiles.ResultsBy PCR, among 100 samples, 45% [95% confidence interval (CI): 35.62%–54.76%] were positive for E. faecium. Based on antibiogram, all the E. faecium isolates were found resistant to ampicillin, and frequently (93.33%–55.56%) resistant to ceftriaxone, cefotaxime, streptomycin, erythromycin, and imipenem; moderate to lower (26.67%–4.44%) resistance to tetracycline, ciprofloxacin, norfloxacin, chloramphenicol, gentamicin, and vancomycin. Interestingly, 80% (95% CI: 66.18%–89.10%) E. faecium isolates were MDR in nature. In addition, the indices of multiple antibiotic resistance (MAR) ranged from 0.08 to 0.83. By bivariate analysis, high positive significant correlations were observed between resistance profiles of erythromycin and imipenem, ciprofloxacin and norfloxacin, erythromycin and streptomycin, ceftriaxone and cefotaxime, tetracycline and chloramphenicol, and streptomycin and imipenem. Furthermore, the prevalence of resistance genes of E. faecium was 58.33% (tetA), 33.33% (tetB), 35.56% (blaTEM), 60% (CITM), 13.33% (aadA1), and 12% (SHV).ConclusionsTo the best of our knowledge, this is the first study in Bangladesh to detect MDR and MAR E. faecium and their associated resistance genes. The detection of MDR and MAR E. faecium and their corresponding resistance genes from healthy broilers is of public health concern because of their potential to enter into the food chain.
Contested climate policies and the four Ds of public participation: From normative standards to what people want
Authors: Perlaviciute Goda 
Published: November 2021

AbstractStimulating public participation in decision making is heralded as a way to get climate policies accepted by the public. Yet, little is known about whether and when public participation can increase policy acceptability. This is true in particular of practices organized by responsible parties to engage the public in decision making. Based on a vast body of interdisciplinary literature, four types of normative standards for effective public participation can be distilled, which I call the four Ds: dialogue, decision‐making power, diversity, and deliberation. However, normative standards may not be enough for reaching socially acceptable climate policies, if people do not want to participate, or want to participate too late in decision making, and are not open to different perspectives. The result can be fake participation, exclusion, and polarization—all which may reduce, rather than increase, public acceptability of climate policies. Understanding public preferences for participation is therefore critical for the implementation of the four Ds and for reaching socially acceptable climate policies. This Perspective article is relevant for scientists, policy makers, NGO's, businesses, interest groups, and other parties wanting to understand how to engage the public in climate decision making.This article is categorized under:
Perceptions, Behavior, and Communication of Climate Change > Perceptions of Climate Change
Policy and Governance > Governing Climate Change in Communities, Cities, and Regions
Covariant chiral kinetic equation in non-Abelian gauge field from “covariant gradient expansion”
Authors: Luo Xiao-Li , Gao Jian-Hua 
Published: November 2021

Abstract
We derive the chiral kinetic equation in 8 dimensional phase space in non- Abelian SU(N) gauge field within the Wigner function formalism. By using the “covariant gradient expansion”, we disentangle the Wigner equations in four-vector space up to the first order and find that only the time-like component of the chiral Wigner function is independent while other components can be explicit derivative. After further decomposing the Wigner function or equations in color space, we present the non-Abelian covariant chiral kinetic equation for the color singlet and multiplet phase-space distribution functions. These phase-space distribution functions have non-trivial Lorentz transformation rules when we define them in different reference frames. The chiral anomaly from non-Abelian gauge field arises naturally from the Berry monopole in Euclidian momentum space in the vacuum or Dirac sea contribution. The anomalous currents as non-Abelian counterparts of chiral magnetic effect and chiral vortical effect have also been derived from the non-Abelian chiral kinetic equation.
Interpretation of LHC excesses in ditop and ditau channels as a 400-GeV pseudoscalar resonance
Authors: Arganda Ernesto , Da Rold Leandro , Díaz Daniel A. , Medina Anibal D. 
Published: November 2021

AbstractSince the discovery in 2012 of the Higgs boson at the LHC, as the last missing piece of the Standard Model of particle physics, any hint of new physics has been intensively searched for, with no confirmation to date. There are however slight deviations from the SM that are worth investigating. The CMS collaboration has reported, in a search for heavy resonances decaying int$$ \overline{t} $$t¯with a 13-TeV center-of-mass energy and a luminosity of 35.9 fb−1, deviations from the SM predictions at the 3.5σlevel locally (1.9σafter the look-elsewhere effect). In addition, in the ditau final state search performed by the ATLAS collaboration at$$ \sqrt{s} $$s= 13 TeV and$$ \mathcal{L} $$L= 139 fb−1, deviations from the SM at the 2σlevel have been also observed. Interestingly, both slight excesses are compatible with a new pseudoscalar boson with a mass around 400 GeV that couples at least to fermions of the third generation and gluons. Starting from a purely phenomenological perspective, we inspect the possibility that a 400-GeV pseudoscalar can account for these deviations and at the same time satisfy the constraints on the rest of the channels that it gives contributions to and that are analyzed by the ATLAS and CMS experiments. After obtaining the range of effective couplings compatible with all experimental measurements, we study the gauge invariant UV completions that can give rise to this type of pseudoscalar resonance, which can be accommodated in an SO(6)/SO(5) model with consistency at the 1σlevel and in a SO(5) × U(1)P× U(1)X/SO(4) × U(1)Xat the 2σlevel, while exceedingly large quartic couplings would be necessary to account for it in a general two Higgs doublet model.
Risk factors for poor outcomes of spontaneous supratentorial cerebral hemorrhage after surgery
Authors: Zhang Kangwei , Wei Lai , Zhou Xiang , Yang Baoqing , Meng Jinxi , Wang Peijun 
Published: November 2021

Abstract
Objective
This study aimed to explore the factors affecting the outcomes of spontaneous supratentorial cerebral hemorrhage 90 days after surgery.

Methods
A total of 256 patients with spontaneous supratentorial intracerebral hemorrhage underwent craniotomy evacuation of hematoma. The control group included 120 patients who received conservative treatment. The patients were divided into two subgroups based on a bifurcation of the modified Rankin Scale (mRS) 90 days after clinical therapeutics: good outcome (mRS score 0–3) and poor outcome (mRS score 4–6). The differences in clinical and imaging data between the two subgroups were analyzed. Based on difference analysis results, a binary logistic regression model was constructed to analyze the influencing factors related to poor outcomes.

Results
The difference analysis results in the surgery group showed statistically significant differences in age, sex, Glasgow Coma Score (GCS) on admission, coronary atherosclerosis, smoking, stroke history, blood glucose, D-dimer, hematoma size, deep cerebral hemorrhage, midline shift, hematoma burst into the ventricle, vortex sign, island sign, and black hole sign. Binary logistic regression analysis showed that deep cerebral hemorrhage, midline shift, and age > 58 years independently correlated with the poor outcomes of patients after surgery. The binary logistic regression results of the control group showed that age > 58 years and GCS ≤ 8 independently correlated with the poor outcomes of patients.

Conclusions
Deep cerebral hemorrhage, midline shift, and age > 58 years significantly increased the risk of adverse prognosis in patients after surgery. The findings might help select the clinical treatment plan and evaluate the postoperative prognosis of patients.
Vascular endothelial growth factor ameliorated palmitate-induced cardiomyocyte injury via JNK pathway
Authors: Wang Shi-ya , Zou Cao , Liu Xiao-feng , Yan Yon-jin , Gu Shun-zhon , Li Xun 
Published: November 2021

AbstractEnhanced apoptosis of cardiomyocytes in suffering overloaded saturated fatty acids (SFAs) can result in myocardial infarction and cardiac dysfunction. The function of vascular endothelial growth factor (VEGF) in cardiomyocyte protection was not clearly described. To investigate the preservative effects of VEGF sensitization on ceramide-mediated programmed cell death of cardiomyocytes, palmitate-induced injury in H9c2 cells was established as an in vitro model. Results revealed that 0.5 mM palmitate application effectively led to debased viability and activated apoptotic factors. A significant time-dependent relation between PAL and cardiomyocyte injury was observed. The apoptosis rate was increased greatly after 16 h of treatment with 0.5 mM PAL. In addition, cell viability was restored by VEGF overexpression during treatment with 0.5 mM PAL. Reduced apoptosis rate and expression of caspase 3, Bax, and NF-κB p65 were observed in this process, while boosted Bcl-2, p-JNK/JNK expression and activity of caspase 3 were checked. However, p-ERK/ERK levels did not exhibit a significant change. These findings indicated the protective effects of VEGF in confronting the ceramide-induced cardiomyocyte apoptosis, and would devote therapeutic targets for cardiovascular safeguard in dealing with fatty acid stress.
Brain structural and functional anomalies associated with simultanagnosia in patients with posterior cortical atrophy
Authors: Cui Yue , Liu Yang , Yang Caishui , Cui Chunlei , Jing Donglai , Zhang Xuxiang , Chen Yaojing , Li Bingkun , Liang Zhigang , Chen Kewei , Zhang Zhanjun , Wu Liyong 
Published: November 2021

AbstractSimultanagnosia is a common symptom of posterior cortical atrophy, and its association with brain structural and functional changes remains unclear. In our study, 18 posterior cortical atrophy patients with simultanagnosia, 29 patients with Alzheimer’s disease and 20 cognitively normal controls were recruited and subjected to full neuropsychological evaluation, including simultanagnosia tests, and structural and resting-state functional MRI. The gray matter volume was assessed by voxel-based morphometry, while the intrinsic functional connectivity was evaluated using the reduced gray matter volume regions of interest as the seed. In contrast to the patients with Alzheimer’s disease, those with posterior cortical atrophy showed the following: (1) markedly lower simultanagnosia test scores, (2) an altered regional gray matter volume of the left middle occipital gyrus and ventral occipital areas, and (3) lowered intrinsic functional connectivity with the left middle occipital gyrus, left lingual gyrus and right middle occipital gyrus separately. Additionally, the gray matter volume of the left middle occipital gyrus and left inferior occipital gyrus were each correlated with simultanagnosia in posterior cortical atrophy patients. The intrinsic functional connectivity of the left middle occipital gyrus with the right superior occipital gyrus and that of the right middle occipital gyrus with the left superior parietal gyrus were also correlated with simultanagnosia in posterior cortical atrophy patients. In summary, this study indicated that simultanagnosia is associated with gray matter reductions and decreased functional connectivity in the left middle occipital gyrus and the left inferior occipital gyrus in patients with posterior cortical atrophy.
The Influence of Developmental Contexts in Adolescent’s Expected Sociopolitical Participation through the Sense of Unity: An Analysis of the Mediation Model Invariance through Sex, Age, and Socioeconomic Status
Authors: Salado Vanesa , Moreno-Maldonado Concepción , Moreno Carmen , Rivera Francisco 
Published: November 2021

AbstractCivic engagement plays a positive role in adolescent wellbeing, as well as being the basis for maintaining a democratic society. This research analyzed how perceived support from developmental contexts contributes to adolescent civic engagement –assessed through their expectations of future sociopolitical participation–, mediated by sense of unity, and differences according to sex, age, and socioeconomic status. The sample included 3,715 participants (13–18 years old) from the 2019OPINA Barometerwho were selected using multistage random sampling stratified by conglomerates. The measures assessed sex, age, family, friends, classmates, and teacher support, the expectations of future sociopolitical participation, and sense of unity. Socioeconomic status was assessed by the Family Affluence Scale (FAS). Data analysis was conducted using descriptive statistics, mean comparisons, and structural equation models using bootstrapping and measurement invariance. Results showed developmental contexts to significantly affect expected sociopolitical participation only through the mediator role of the sense of unity. In addition, peer support (both friends and classmates) showed a stronger direct influence on sense of unity –and indirect influence on the expectations of future sociopolitical participation– than family and teachers. The model was invariant across sex, age, and FAS. This research highlights that a sense of unity, derived from feeling part of a larger dependable structure, is crucial for establishing behaviors in the interest of the common good, and that this social connectedness is learned in the most immediate developmental contexts, specifically, that of peers.
‘What’s the Problem Represented to Be?’ The Place and Wellbeing of Young People in Azerbaijan’s Drug Policy
Authors: Sultan Aysel 
Published: November 2021

AbstractThis policy paper bridges interdisciplinary research to analyze the effects of drug policy in Azerbaijan on the provision of social care and treatment for young people who use illicit drugs. Drawing on Carol Bacchi’s critical policy analysis method – ‘what’s the problem represented to be’ – the paper focuses on what the state’s drug policy enables and/or impedes in the implementation of better protection and care for young people aged between 14 and 17. To do this, two texts are selected for the analysis to explore representations and social construction of youth through various problematizations in policy legislations. The analysis suggests that drug policy in Azerbaijan is formulated to further cultural and political purposes to maintain a community-based immunity to drugs, rather than psycho-social and medical interventions or individual engagement with young people’s wellbeing.
Evaluation of stability in maize hybrids using univariate parametric methods
Authors: Shojaei Seyed Habib , Mostafavi Khodadad , Lak Amirparviz , Omrani Ali , Omrani Saeed , Mousavi Seyed Mohammad Nasir , Illés Árpád , Bojtor Csaba , Nagy János 
Published: November 2021

AbstractGenotype × environment interaction is one of the complex issues of breeding programs to produce high-yielding and compatible cultivars. Interaction of genotype × environment and make the more accurate selection, the performance and stability of hybrids need to be considered simultaneously. This study aimed to investigate stable genotypes with yield using 12 maize hybrids in different climatic conditions of Iran. The experimental design used was a randomized complete blocks design in three replications in two cropping years in Karaj, Birjand, Shiraz, and Arak stations. The simple analysis of variance performed on grain yield of genotypes indicated that all hybrids studied each year and station were significantly different in grain yield. Also, the combined analysis results showed a significant effect on the environment, the effects of genotype, and the interaction of genotype × environment and t in the studied hybrids different. Comparing Duncan's mean on the data obtained from the research, KSC705 genotypes with an average yield of 7.21 and KSC704 genotype with an average yield of 7.04 were identified as high yield cultivars. In order to identify stable cultivars, six stability parameters were used. KSC260 and KSC707 genotypes had stability Based on the environmental variance, also had stability based KSC705, KSC707 genotype on environmental the coefficient of variation, and KSC260 genotypes had stability based methods of genotype and environment interaction. As well as based on Eberhart and Russell regression coefficient had the stability to KSC400 and SC647 genotypes. Also, they were identified as the most stable genotypes based on the detection coefficient method, KSC707, and KSC703 genotypes.
Knowledge politics in the smart city: A case study of strategic urban planning in Cambridge, UK
Authors: Nochta Timea , Wahby Noura , Schooling Jennifer M. 
Published: November 2021

AbstractThis paper highlights the need and opportunities for constructively combining different types of (analogue and data-driven) knowledges in evidence-informed policy decision-making in future smart cities. Problematizing the assumed universality and objectivity of data-driven knowledge, we call attention to notions of “positionality” and “situatedness” in knowledge production relating to the urban present and possible futures. In order to illustrate our arguments, we draw on a case study of strategic urban (spatial) planning in the Cambridge city region in the United Kingdom. Tracing diverse knowledge production processes, including top-down data-driven knowledges derived from urban modeling, and bottom-up analogue community-based knowledges, allows us to identify locationally specific knowledge politics around evidence for policy. The findings highlight how evidence-informed urban policy can benefit from political processes of competition, contestation, negotiation, and complementarity that arise from interactions between diverse “digital” and “analogue” knowledges. We argue that studying such processes can help in assembling a more multifaceted, diverse and inclusive knowledge-base on which to base policy decisions, as well as to raise awareness and improve active participation in the ongoing “smartification” of cities.
Typical properties of periodic Teichmüller geodesics: Lyapunov exponents
Authors: HAMENSTÄDT URSULA 
Published: November 2021

AbstractConsider a component
${\cal Q}$
of a stratum in the moduli space of area-one abelian differentials on a surface of genus g. Call a property
${\cal P}$
for periodic orbits of the Teichmüller flow on
${\cal Q}$
typical if the growth rate of orbits with property
${\cal P}$
is maximal. We show that the following property is typical. Given a continuous integrable cocycle over the Teichmüller flow with values in a vector bundle
$V\to {\cal Q}$
, the logarithms of the eigenvalues of the matrix defined by the cocycle and the orbit are arbitrarily close to the Lyapunov exponents of the cocycle for the Masur–Veech measure.