bluuebunny/crossref_metadata_2025_split huggingface dataset:
PROBLEMATIZANDO OS PCNEM+ PARA A ATIVIDADE DOCENTE DE FILOSOFIA - Doi: http://dx.doi.org/10.5212/OlharProfr.v.11i1.123135
Authors: Jacinski Edson , Vitkowski José Rogério 
Published: February 2021

Resumo: O presente texto estabelece um diálogo com os PCN+ e explora a relação entre filosofia, educação e ensino, a partir da prática educacional auto-reflexiva dos autores, fecundada pela perspectiva teórica de Deleuze e Felix Guatari. Pretende-se aqui explicitar alguns dos principais sentidos da atividade filosófica na educação formal secundária buscando-se elementos que possibilitem revitalizar a atividade docente. Desse modo, a abordagem se dá a partir da perspectiva do ensino, problematizando posturas didático-pedagógicas e as ambigüidades da inserção institucional da Filosofia como disciplina, sem descurar da necessária demarcação epistêmica. A abordagem de tais questões opera-se a partir da perspectiva da metarreflexão sobre a própria filosofia, sugerindo-se a superação do ensino da Filosofia como atividade meramente contemplativa, reflexiva ou comunicativa e propondo-se pensá-la na ótica deleuziana como criação de conceitos, o que pode permitir uma ressignificação da tradição filosófica, redimensionando criticamente o olhar sobre o cotidiano.
Publication Rates of Pediatric-Focused Resident Research Projects Presented at The Pediatric Pharmacy Association Bruce Parks Memorial Residency Showcase
Authors: Miller Jamie L. , Lewis Teresa V. , Walling Jennifer , O'Donnell Abriel , Neely Stephen B. , Johnson Peter N. 
Published: February 2021

OBJECTIVES
The primary objective was to identify the number of residency projects presented at the Pediatric Pharmacy Association (PPA) Bruce Parks Memorial Residency Showcase that were subsequently published. Secondary objectives included a comparison of subsequent publications after residency completion between those who did and did not publish their residency project and an analysis of factors associated with subsequent publications.

METHODS
This was a descriptive study including all pediatric-focused resident projects presented at the PPA Bruce Parks Memorial Residency Showcase from 2006 to 2015. Literature searches for all the pediatric-focused residency projects and any subsequent publications were performed. Data collection included residency type (i.e., postgraduate year 1 [PGY1], postgraduate year 2 [PGY2]), project category, and initial position after residency. A zero-inflated Poisson regression was used to analyze subsequent publication status while controlling for other factors. Statistical analyses were performed using SAS/STAT, with a priori p value &lt; 0.05.

RESULTS
There were 434 projects presented by 401 residents. Seventy-four (17.1%) were published, with the majority being PGY2s (74.3%). Subsequent publications were identified for 162 residents (40.4%), with a higher percentage in those who published their pediatric-focused residency project versus those who did not, 59.5% versus 32.8%, p &lt; 0.001. Factors associated with subsequent publications were those who published their residency project, initial position in academia, and PGY2s.

CONCLUSIONS
Of the residency projects presented at the showcase &lt;20% were subsequently published. Those who published their residency research project were more likely to have subsequent publications. Future efforts should be taken to ensure that residents have the tools/confidence to independently publish their research/scholarship.
Osmolality of Commonly Used Oral Medications in the Neonatal Intensive Care Unit
Authors: Shah Dhara D. , Kuzmov Andriy , Clausen Dana , Siu Anita , Robinson Christine A. , Kimler Katelin , Meyers Rachel , Shah Pooja 
Published: February 2021

OBJECTIVEThe administration of hyperosmolar oral products in neonates has been associated with gastrointestinal complications. The American Academy of Pediatrics recommends a maximum osmolality of 450 mOsm/kg for formulas and enteral nutrition for term infants, and recent studies reported intolerance to enteral nutrition with osmolality above 500 mOsm/kg in low birthweight infants. The osmolality of medications administered to neonates is often not available in the literature or from manufacturers. The purpose of this study was to determine the osmolality of oral medications commonly administered to neonates in the NICU.METHODSFifty-two oral medications were chosen for this study, including solutions, suspensions, syrups, elixirs, and intravenous solutions administered orally. The osmolality of each medication was measured in triplicate by using freezing point depression.RESULTSThirty-seven of the 43 medications with measurable values (86.1%) had an osmolality greater than 500 mOsm/kg, and 6 medications (14%) had an osmolality less than 500 mOsm/kg. Nine medications did not result in a value.CONCLUSIONSOur study provides osmolality data on oral medications commonly used in neonates with most oral medications having an osmolality greater than 500 mOsm/kg.
Impact of Body Habitus on the Outcomes of Pediatric Patients With Diabetic Ketoacidosis
Authors: Moffett Brady S. , Allen Joseph , Khichi Mahmood , McCann-Crosby Bonnie 
Published: February 2021

OBJECTIVE
To determine whether obese and overweight pediatric patients with new onset diabetic ketoacidosis (DKA) treated with continuous infusion insulin have increased time to subcutaneous insulin initiation or adverse events as compared with patients with normal body habitus.

METHODS
A retrospective, cohort study was designed that included patients 2 to 18 years of age admitted with new onset DKA who received continuous infusion insulin from January 1, 2011, to December 31, 2017. Patients were stratified according to BMI percentile with the primary outcome of time to initiation of subcutaneous insulin. Secondary endpoints included time to minimum beta-hydroxybutyrate, and incidence of hypoglycemia or other adverse events.

RESULTS
A total of 337 patients (46.6% male, 9.6 ± 3.8 years of age) met study criteria. Patients were classified by body habitus as obese (7.7%, n = 26), overweight (7.1%, n = 24), normal body weight (58.8%, n = 198), or underweight (26.4%, n = 89), based on BMI percentile. Most patients were initiated on insulin at 0.1 unit/kg/hr (86.7%) for 16.7 ± 7.0 hours. Time from continuous infusion insulin initiation to subcutaneous insulin was not different between body habitus groups, nor was hypoglycemia or the use of mannitol (p &gt; 0.05). Median time to lowest beta-hydroxybutyrate was greater for obese (26.4, IQR [13.9, 41.9]) and overweight (32.4, IQR [18.3, 47.0]) groups than for normal body habitus patients (16.5, IQR [12.3, 23.8]) (p &lt; 0.05).

CONCLUSIONS
Time to subcutaneous insulin and adverse events was not associated with body habitus, but obese and overweight patients may have delayed beta-hydroxybutyrate clearance.
The Museum and the Killing Jar
Authors: Bailey Andrew Remington 
Published: February 2021

Within the Animal Crossing series, players have always had the ability to collect insects and then donate them to a museum where they can then be permanently exhibited. This paper makes the argument that this collecting and exhibiting of game objects works to reflect many of the ways that videogames have begun to take up an increasingly prominent place within real world institutional exhibitions, archives, and collections. Through a conjoined lens that is equally informed by games preservation, etymology, and art history this essay works to unpack the intricacies of how the museum and collecting function with the Animal Crossing series. This examination of Animal Crossing will then be applied more broadly to two museums (the MoMA and the V&A) exhibition case studies, making the comparative argument that overtly taxonomic methods of display and archiving can work to deaden videogames’ inherently mutable vitality. By speculatively thinking of videogames as things akin to the bugs of Animal Crossing, to be kept alive throughout the archival process rather than dead objects to be preserved, a new, more productive lens of videogame curation can be gleaned.
A Slow Burning Fire
Authors: Ilić Marko 
Published: February 2021

The first comprehensive study of the former Yugoslavia's diverse and groundbreaking alternative art scenes from the 1960s to the 1980s.
This first comprehensive study of the former Yugoslavia's alternative art scene tells the origin stories of some of the most significant artists of the late twentieth century. In Yugoslavia from the late 1960s to the late 1980s, state-supported Students' Cultural Centers became incubators for new art. This era's conceptual and performance art—known as Yugoslavia's New Art Practice—emerged from a network of diverse and densely interconnected art scenes that nurtured the early work of Marina Abramović, Sanja Iveković, Neue Slowenische Kunst (NSK), and others. In this book, Marko Ilić examines Yugoslavia's New Art Practice in light of the political upheavals of the 1980s.
Countering the usual binary of official versus unofficial art, Ilić shows that the Students' Cultural Centers were an expression of Yugoslavia's “third way” political and economic system, which was founded on workers' self-management. Ilić examines key actions, gestures, and propositions affiliated with the New Art Practice, including the conceptual and dematerialized art practices that emerged from Zagreb's Student Center Gallery, the struggle of Belgrade's Students' Cultural Center (where Abramović performed her career-defining Rhythm 5), to break into the international art scene, the pre-Žižek culture of Ljubljana, and Sarajevo's miraculous dokumenta, held in the midst of Yugoslavia's disintegration.
Immunocytochemical study of phenotypic plasticity of cultured dorsal root ganglion neurons during development
Authors: Chauvet N. , Drian M.‐J. , Privat A. 
Published: July 2002

AbstractRat dorsal root ganglia (DRG) were cultured from different stages of development ranging from embryonic day‐14 to adult. The expression of eight neurotransmitter phenotypes was examined with immunocytochemical detection and the percentages of each phenotype were calculated with reference to the whole neuronal population defined by the expression of neuron‐specific enolase (NSE). The expression of peptides, calcitonin gene‐related peptide (CGRP), substance P (SP), cholecystokinin (CCK) and neuropeptide Y (NPY) was always present whatever the age at onset of the cultures. Although the percentage of CGRP remained stable, that of the other peptides declined progressively. Their in‐vitro expression did not differ marked from that found in vivo. Another group of neurotransmiiters, including 5‐hydroxytryptamine (5‐HT), thyrotropin‐releasing hormone (TRH) and gamma‐aminobutyric acid (GABA) was never expressed in situ in DRG neurons. In culture, they were expressed in a high percentage of neurons, especially for 5‐HT and TRH, and they showed a similar evolution, with a decrease at early postnatal ages followed by a further increase. This profile suggests that the expression of these transmitters is strongly environment‐dependent and may be repressed in situ. Finally, somatostatin (SOM) was found only in cultures prepared from adult tissues, whereas it was present in situ from the embryo onwards. The expression of this peptide would thus require a stabilization by a long exposure to environmental factors.We can conclude that the great diversity of phenotypic expression found in DRG neurons in situ is the result of a wide variety of influences occurring at different stages of development in a large potential repertory present in these neurons.
Atypical neuroleptics: their contribution to the rehabilitation of schizophrenic patients
Authors: Vanelle JM , Brochier T , Baylé FJ , Lôo H 
Published: July 2002

SummaryTherapeutic effects of neuroleptics (NLP) in schizophrenia are well established in numerous international studies. Varying modalities of evolution under NLP treatment are described and require a clinical analysis. Neuroleptics are a necessary but insufficient condition for the therapy of schizophrenia. Via NLP treatment, other therapeutic approaches, such as psychotherapy, or sociotherapy become more effective. Consecutively, we present the effects of two compounds with dopaminergic selective activity (amisulpride, remoxipride) and of two other compounds with non-selective activity (risperidone, clozapine) regarding rehabilitation in schizophrenic patients. Data were collected from international studies with a medico-economic perspective and from French experience of clozapine in refractory schizophrenic patients. All these data stress the importance of several areas of study: clinical features, everyday life consequences and therapeutical effects observed with the atypical neuroleptics.
Doppler blood flow velocity waveforms of the umbilical artery during variable decelerations in labor
Authors: Sakai M. , Kozuma S. , Okai T. , Kagawa H. , Ryo E. , Taketani Y. 
Published: July 2002

AbstractObjective: To investigate the changes in resistance indices of blood flow velocity waveforms of the umbilical artery (UmA‐RIs) during variable decelerations (VDs) vs. early decelerations (EDs). Methods: UmA‐RIs were measured before and during uterine contractions in 30 cases with VDs, nine cases with EDs and 20 cases without decelerations. In 12 out of 30 cases with VDs, UmA‐RI was determined at the following five stages of a VD; before the deceleration, downward, bottom, upward and resumption stages. Results: UmA‐RIs during VDs were significantly higher compared with those at preceding periods. UmA‐RIs at downward and bottom stages of VDs were significantly higher than those at the upward stage, although no differences in heart rate were found between downward and upward stages. UmA‐RIs during EDs or uterine contractions without decelerations did not differ from those preceding them. Conclusion: UmA‐RIs increased during VDs, particularly at downward and bottom stages during which the cord seemed to be actually compressed.
Evaluation of interobserver agreement of cardiotocograms
Authors: Bernardes J. , Costa‐Pereira A. , Ayres‐de‐Campos D. , Geijn H.P.van , Pereira‐Leite L. 
Published: July 2002

AbstractObjective: To evaluate interobserver agreement in visual analysis of each cardiotocographic event. Methods: Three experts independently divided 16 antepartum and 17 intrapartum cardiotocograms into baseline segments, accelerations and decelerations, according to the FIGO guidelines. Baseline segments were further classified as having normal, reduced or increased variability and decelerations as early, late and variable. Uterine activity was divided into tonus and contractions. Agreement was assessed by the proportions of agreement (pa) with 95% confidence intervals. Results: Reproducibility in assessment of baseline segments with normal variability, accelerations and uterine activity was acceptable (pa = 0.56–0.71) whereas that of other segments was not (pa = 0.14–0.45). Conclusions: Analysis of most cardiotocographic events is poorly reproducible, even when experts use the FIGO guidelines. This may be explained by some still ambiguous guidelines, by eyeball limitations in evaluation of subtle events, and by the incapacity of busy clinicians to assess complex and multiple cardiotocographic events in a systematic and disciplined fashion.
Objective computerized fetal heart rate analysis
Authors: Bernardes J , Ayres‐de‐Campos D , Costa‐Pereira A , Pereira‐Leite L , Garrido A 
Published: July 2002

AbstractObjective: To assess the validity of a computerized methodology for cardiotocogram analysis based on a recently described reproducible visual estimation of the baseline. Methods: Forty‐two antepartum and 43 intrapartum cardiotocograms (CTGs) acquired by a personal computer were selected. Antepartum tracings were performed in the 48 h that preceded an elective cesarean section, and intrapartum tracings were performed until delivery. FHR baselines were estimated by an expert, according to an objective and reproducible methodology. Using these baselines, automated detection of accelerations and decelerations and estimation of variability was performed by the personal computer. A quantitative adaptation of the FIGO guidelines for fetal monitoring was used to classify tracings. Perinatal outcome was classified according to the Apgar score and umbilical arterial pH. Validity was then assessed by the proportions of agreement (PA), kappa statistic (κ), sensitivity and specificity, with 95% confidence intervals (95% CI). Cases showing a disagreement between CTG and perinatal classification were reviewed and an adjustment in baseline definition was tested. Results: The initial overall PA and κ between CTG and perinatal classification were, respectively, 0.79 (95% CI: 0.69–0.87) and 0.62 (95% CI: 0.41–0.83). The overall PA and κ, after baseline adjustment were, respectively, 0.89 (95% CI: 0.81–0.95) and 0.78 (95% CI: 0.58–0.98). Sensitivities and specificities ranged between 79% (95% CI: 60–92%) and 100% (95% CI: 95–100%). Conclusions: Good clinical prediction may be possible with an objective methodology for cardiotocogram analysis based on a recently described reproducible baseline estimation.
Sonographic diagnosis of intrauterine growth restriction (IUGR) by fetal transverse cerebellar diameter (TCD)/abdominal circumference (AC) ratio
Authors: Tongsong T. , Wanapirak C. , Thongpadungroj T. 
Published: July 2002

AbstractObjective: To evaluate the validity of TCD/AC ratio in predicting IUGR. Study design: Prospective descriptive analysis. Setting: Maharaj Nakorn Chiang Mai Hospital, Chiang Mai University. Subjects: Women meeting the inclusion criteria consisting of: (1) singleton pregnancies after 28 weeks of gestation; (2) known accurate gestational age; and (3) clinically suspected IUGR. Methods: The patients were sonographically examined for TCD/AC ratio. The best cut‐off value of TCD/AC ratio in predicting IUGR was determined by a receiver operating characteristic (ROC) curve. The fetus with a TCD/AC ratio greater than the cut‐off value would be antenatally diagnosed as IUGR for every gestational week. Standard definition of IUGR was a low birthweight, less than the l0th percentile. Results: One hundred and sixty‐seven pregnancies with suspected IUGR were analyzed. The prevalence of IUGR among the study group was 51.5%. The best cut‐off value of the TCD/AC ratio for predicting IUGR was 15.4%, giving the sensitivity, specificity, positive predictive value and negative predictive value of 73.26%, 80.25%, 79.75%, and 73.86%, respectively. Conclusion: The sonographic fetal TCD/AC ratio as a gestational age‐independent method can be helpful in antenatal diagnosis of IUGR, especially in pregnancy with uncertain gestational age.
Innovation implementation in high technology manufacturing: A chaos‐theoretic empirical analysis
Authors: Jayanthi Shekhar , Sinha Kingshuk K. 
Published: July 2002

AbstractThis paper conceptualizes the process of innovation implementation in high technology manufacturing, a natural setting of multiple and ongoing innovation implementation. Building on the developments in organizational learning theory, we frame the process of innovation implementation in high technology manufacturing as a problem of balancing between exploitation and exploration. Through the application of a logistic difference equation, we provide insights into the dynamics of balancing between exploitation and exploration, and show that innovation implementation in high technology manufacturing can be conceptualized as a chaotic process, in a scientific sense. Using time series data from a wafer fabrication plant, the high technology manufacturing plant that served as our research site over a period of 125 weeks, we test this conceptualization. We find empirical support for the conceptualization of innovation implementation in high technology manufacturing as a chaotic process. We discuss the managerial implications of our study's findings, and the directions for the future research.
Optimization tools for design and marketing of new/improved products using the house of quality
Authors: Vairaktarakis George L. 
Published: July 2002

AbstractQuality function deployment (QFD) has helped many firms realize significant reduction in product design costs and development time. The QFD process includes ranking customer preferences, rating the competitors, and parts deployment for the new/improved product. Prior to this research, such activities have been performed based on expert opinion, or the “best‐in‐class” approach. We develop and solve optimization models for the identification of consensus rankings and ratings, that take into account the priorities and perceptions of all the customers in a target market. Then, based on the consensus rankings, we identify a parts mix for the new/improved product that satisfies a budget constraint and matches or exceeds the performance expectations of all customers surveyed in the target market. Finally, we show how the QFD charts can be used to identify competitors that are falsely perceived as superior, as well as areas where the firm's marketing strategies have had the desired effects. Such insights are useful in developing the future marketing strategy of the firm.
Neonatal 6‐hydroxydopamine treatment affects GABAA receptor subunit expression during postnatal development of the rat cerebellum
Authors: Podkletnova I. , Alho H. , Mäkelä R. , Lüddens H. , Helén P. , Korpi E.R. 
Published: July 2002

AbstractNeurotoxic elimination of noradrenergic terminals by 6‐hydroxydopamine (6‐OHDA) leads to alteration of the granule cell layer formation. We have studied the developmental expression of GABAA receptor subunits in rat cerebellum after neonatal administration of 6‐OHDA during the first postnatal month of life. 6‐OHDA was injected subcutaneously. The expression of GABAA receptor subunits was studied by in situ hybridization and immunohistochemistry. The alterations were observed in the neocerebellum — the part of the cerebellum which starts development postnatally. The migration of granule cells was delayed, and the total area of the granule cell layer in the neocerebellum from 6‐OHDA‐treated rats was reduced to 22.6±5% of the corresponding area from control rats. In situ hybridization with subunit‐specific antisense oligonucleotide probes was performed for α1, α2, α3, α5, α6, β1, β2, γ1 and γ2 subunits of the GABAA receptor. In neocerebellum, 6‐OHDA treatment caused a significant reduction in the α1, α6 and γ2 subunit mRNA levels. The expression of the other subunits was not changed. It has been shown that in the postnatal cerebellum α1 and α6 subunits can be detected in granule cells only when the cells had migrated to their final destination. Our findings indicate that a noradrenergic influence may be necessary for the normal maturation and migration of cerebellar granule cells.