bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ecosystem Services Provided By Urban Forests In The Southern Caucasus Region: A Modeling Study In Tbilisi, Georgia
Authors: Alpaidze Levan , Pace Rocco 
Published: July 2021

Abstract
All cities globally are growing considerably as they are experiencing an intensive urbanization process resulting in significant economic, social, and environmental challenges. One of the major risks is the deterioration of living environment in urban areas due to the high soil consumption and pollution of environmental components. For this reason, cities are required to adopt measures to reduce air pollution concentration and CO2 emissions, preserve biodiversity and mitigate the urban heat island effect. In this context, tree planting has been suggested as a cost-effective strategy because green infrastructures can provide important environmental and social functions which contribute to the quality of life and health of city dwellers.Tbilisi is the largest city in Georgia, with a population of over 1,100,000 inhabitants (about 30% of total population of Georgia). The green space availability in Tbilisi (5-6 m2 per inhabitant) is low compared to other European cities, and in recent years the need to increase the amount of urban vegetation has been underlined at planning level.In our study, we implemented for the first time in a Southern Caucasus city the i-Tree Eco model to quantify the main ecosystem services provided by urban forests. Trees in two parks in Tbilisi, Expo Park (694 trees) and Red Park (1027 trees), have been measured and a model simulation was performed for the year 2018. These green infrastructures store large amounts of carbon in their woody tissues (198.4 t for Expo Park and 126.5 t for Red Park) and each year they remove 4.6 and 4.7 t of CO2 for Expo Park and Red Park. They also positively contribute to the air quality by removing 119.6 and 90.3 kg of pollutants (CO, NO2, O3, PM2.5, SO2), and reducing water runoff of 269.5 and 200.5 m3, respectively.This analysis highlights the key role of urban forests in improving the environmental sustainability of the city of Tbilisi and provides important decision support for tree species selection in this geographic area with the aim of maximizing the benefits trees can supply to cities.
Efficient Access Method for Multi-access Edge Servers in Dynamic Map Systems
Authors: Hosono Kohei , Maki Akihiko , Watanabe Yosuke , Takada Hiroaki , Sato Kenya 
Published: July 2021

Abstract
Research and development on connected cars equipped with communication functions is being conducted, and dynamic maps are being researched and developed as an information and communication platform for cooperative automatic driving. There is a concern about scalability when dynamic maps are constructed on a cloud server to aggregate a wide range of vehicle information. The problem can be alleviated by deploying edge servers that divide the geographic area where vehicles travel and manage each of them. The IP addresses of the edge servers need to be resolved on the basis of the location information of the moving vehicles. Using TCP improves reliability but reduces efficiency because the vehicles move. In this study, we developed a novel method for accessing edge servers that achieves higher reliability and efficiency by adopting UDP using anycast for transmission from vehicle to edge server and implementing a retransmission function. The effectiveness of this access method was verified by using a vehicle driving simulation.
Sleep Disorder During the Third Wave of COVID-19 Pandemic among Malaysian Adults
Authors: Marzo Roy Rillera , Shekhawat Kuldeep Singh , Chauhan Shekhar , Patel Ratna , Kyaw Thin Mon , Amran Balqis binti , Mat Muhammad Alif Isyraff bin , Rajendiran Villasini A/P , Noor Muhamad Aliff bin Mohd , Acharya Swosti , Shrestha Sunil 
Published: July 2021

Abstract
Background: The outbreak of coronavirus posits deleterious consequences on global healthcare system while affecting human life in every aspect. Despite various measures undertaken to limit the socio-economic effect of coronavirus, various challenges remain pervasive, and one such challenge is mental health, particularly sleep disorders. Therefore, this study examines the prevalence and determinants of sleep disorders among Malaysian adults.Methods: An online survey was conducted from 11 January to May 2021. Structured questionnaire link using Google form was sent to the adults through E-mail in Malaysia. The study utilized Holland Sleep Disorder Questionnaire (HSDQ) to screen out the various sleep disorders, namely; Insomnia, Parasomnia, Circadian Rhythm Sleep Disorder (CRSD), Hypersomnia, Restless Legs Syndrome (RLS/PLMD), and Sleep-disordered Breathing (SDB). Percentage distribution and logistic regression analysis were used as study tools.Results: Around 70% of the surveyed population had one or another sleep disorder. One-third reported RLS/PLMD (34.8%) and CRSD (33.9%). More than one-fourth of the adults reported Insomnia (29.7%) and Hypersomnia (25.8%). Increased risk of sleep disorders was found to be associated with being unemployed (OR=2.4, C.I.=1.17-4.89). The risk of insomnia and hypersomnia was higher among female adults (OR=1.6, C.I.=1.11-2.3) and unemployed adults (OR=2.4, C.I.=1.23-5.04), respectively.Conclusion: Immediate interventions to prevent aggravation of sleep disorders should be promoted. It is recommended to bring forth psychiatric and psychological support to those suffering from various sleep disorders in the ongoing coronavirus pandemic. Government shall impart counselling through various online channels consisting of psychologists and sleep experts to improve the quality of sleep.
Dental pulp stem cells as a therapy for congenital entero-neuropathy
Authors: Yoshimaru Koichiro , Yamaza Takayoshi , Kajioka Shunichi , Sonoda Soichiro , Yanagi Yusuke , Matsuura Toshiharu , Yoshizumi Junko , Oda Yoshinao , Iwata Naoko , Takai Chiho , Nakayama Shinsuke , Taguchi Tomoaki 
Published: July 2021

Abstract
Hirschsprung’s disease (HSCR) and its allied disorders are congenital entero-neuropathies with life-long implications in many cases. Here we report the effects of intravenous transplantation of cultured dental pulp stem cells derived from deciduous teeth (dDPSCs) into ‘Japanese fancy-1’ (JF1) mice with entero-neuropathy caused by Ednrb mutation. Intravenously injected dDPSCs (multipotent neural crest cells with low immunogenicity) migrated to affected regions of the intestine through interactions between stromal cell-derived factor-1α and C-X-C chemokine receptor type-4. Notably, transplanted dDPSCs differentiated into both enteric neurons and pacemaker interstitial cells to correct abnormalities in the electrical and mechanical activities of the proximal colon. dDPSC transplantation also led to repair of the small intestinal mucosa, changes in the gastrointestinal microbiota, improvements in nutritional status and prolongation of survival. We anticipate that dDPSC transplantation could be developed into a novel cell-based therapy for HSCR and its allied disorders.
An Emergency Supplies Scheduling for Chemical Industry Park: Based on Super-Network Theory
Authors: Yuan Yu , Wang Fei 
Published: July 2021

Abstract
In a concentrated area of Chemical Industry Parks (CIPs), emergency relief efficiency is not only affected by the rescue capability of themselves, but also their relationships with other CIPs. Academic literature suggests the use of multiple networks such as transport network and information network, in the emergency process after unexpected events, but rarely integrates them ideally in practice. This paper utilizes the super network theory to propose a regional emergency scheduling model to bridge the logistic and relation among CIPs. The proposed super-network model is composed of resources flow network and relationship network that fill a gap of only considering emergency logistic supply chain. Therefore, the main problem is to how coordinate all the disaster relief actors including primary relief centers (PRC) local relief centers (LRC) and CIPs. The proposed model provides an optional answer regarding the optimal configuration (one-stage or two-stage), the optimal type, number and transportation direction of resources. We turn the optimization problem into a variational inequality problem and develop a modified projection algorithm to solve the problem and compare the performance under several disaster scenarios. The practicability of the model is proved by the result of the numerical example given.
A Natural History Comparison of SOD1-Mutant Patients with Amyotrophic Lateral Sclerosis between Chinese and German Populations
Authors: Tang Lu , Dorst Johannes , Chen Lu , Liu Xiaolu , Ma Yan , Günther Kornelia , Michels Sebastian , Müller Kathrin , Freischmidt Axel , Weishaupt Jochen H. , Fan Dongsheng , Ludolph Albert C. 
Published: July 2021

Abstract
Background: The gene coding the Cu/Zn superoxide dismutase ( SOD1 ) was the first-identified causative gene of amyotrophic lateral sclerosis (ALS), and the second most common genetic cause for ALS worldwide. The promising therapeutic approaches targeting SOD1 mutations are on the road. The purpose of the present study was to compare the mutational and clinical features of Chinese and German patients with ALS carrying mutations in SOD1 gene, which will facilitate the strategy and design of SOD1 -targeted trials.Methods: Demographic and clinical characteristics were collected from two longitudinal cohorts in China and Germany. Chinese and German patients carrying SOD1 mutations were compared with regard to mutational distribution, age of onset, site of onset, body mass index (BMI) at diagnosis, diagnostic delay, progression rate, and survival.Results: A total of 66 Chinese and 84 German patients with 69 distinct SOD1 mutations were identified. The most common mutation in both populations was p.His47Arg. It was found in 8 Chinese and 2 German patients and consistently showed a slow progression of disease in both countries. Across all mutations, Chinese patients showed a younger age of onset (43.9 vs 49.9 years, p=0.002), a higher proportion of young-onset cases (62.5% vs 30.7%, p<0.001) and a lower BMI at diagnosis (22.8 vs 26.0, p<0.001) compared to German patients. Although riluzole intake was less frequent in Chinese patients (28.3% vs 81.3%, p<0.001), no difference in survival between populations was observed (p=0.90). Across both cohorts, female patients had a longer diagnostic delay (15.0 vs 11.0 months, p=0.01) and a prolonged survival (248.0 vs 60.0 months, p=0.005) compared to male patients.Conclusions: Our data demonstrate the distinct mutational and clinical spectrums of SOD1 -mutant patients in Asian and European populations. Clinical phenotypes seem to be primarily influenced by mutation-specific, albeit not excluding ethnicity-specific factors. Further large-scale transethnical studies are needed to clarify determinants and modifiers of SOD1 phenotypes.
The Effect of Aerobic Exercise Training on Cancer Markers and Quality of Life Women with Breast Cancer Patients: A Randomized Controlled Trial
Authors: Kocamaz Deniz , FIDANCIOGLU Nahide AYHAN , Yılmaz Ramazan Cihad , Düger Tülin , Yakut Yavuz 
Published: July 2021

Abstract
Background

Exercise interventions in order to improve disease-related symptoms and improve quality of life in cancer patients are an approach that has received a lot of attention in recent years. The aim of our study is to investigate the effect of aerobic exercise on cancer recovery and to determine the change of cancer markers before and after treatment.
Methods

70 women between 18–65 years were included in this study during chemotherapy. They were part of two groups; aerobic exercise (Group I) and control (Group II) groups. Their demographic features, quality of life and some cancer markers were evaluated. Assessments were done pre-chemotherapy and post-chemotherapy. In aerobic exercise group third a week aerobic exercises on submaximal level applied. A 12-week exercise program was planned, conducted under the supervision of a physiotherapist.
Results

As a result of this study, the quality of life in the aerobic exercise group was significantly higher in breast cancer patients receiving chemotherapy treatment (p < 0.05). The three most commonly used cancer markers were measured in the blood of women with breast cancer pre and post treatment. In the pre-treatment period, the mean serum levels of CEA, CEA 15 − 3, and CEA 19 − 9 were similar in Group I and Group II (p > 0.05). In terms of post-treatment evaluation results, the women in Group I had a greater decrease in CEA, CEA 15 − 3, and CEA 19.9 values than the women in Group II (p < 0.05).
Conclusion

Aerobic exercise has a positive effect on physical function, role function, cognitive state and emotional state, which are subtitles of quality of life. It has been determined that the decrease of cancer markers in blood serum is greater with aerobic exercise.
In Vitro Impact Preliminary Assessment of Airborne Particulate From Metalworking and Woodworking Industries
Authors: Pavlovska Ilona , Ramata-Stunda Anna , Martinsone Zanna , Boroduskis Martins , Patetko Liene , Martinsone Inese , Seile Anita , Vanadzins Ivars 
Published: July 2021

Abstract
Inhalation is the main route of exposure to airborne pollutants. To evaluate the safety and assess the risks of occupational hazards different testing approaches are used. 3D airway epithelial tissues allow to mimic exposure conditions in vitro, generates human-relevant toxicology data, allows to elucidate mode of action of pollutants. Gilian 3500 pumps equipped with Standard Midget Impingers were used to collect the airborne particulate from woodworking and metalworking environments. EpiAirway™ tissues were used to model half working day (4 h), full working day (8 h), and 3 working day exposures to occupational pollutants. Tissue viability was assessed using MTT assay. RT-qPCR analyses performed to analyze the expression of gelsolin, caspase-3, and IL-6. Tissue morphology was assessed by hematoxylin/eosin staining. Acute exposure to workspace pollutants slightly affected tissue viability and did not change the morphology. Both types of particles suppressed expression of gelsolin, with metalworking samples showing the most pronounced effect. A slight reduction in caspase-3 expression was observed. Particles from metalworking suppressed IL-6 expression. 3D Epithelial tissues can be used to model exposures to airborne pollutants. Exposure to particles from woodworking and metalworking had a minor effect on tissue viability but affected the expression of inflammation and apoptosis-related genes.
Time-Series Uncertainty Quantification of Foundation Settlement with Kernel Based Extreme Learning Machine
Authors: Fan Honghui , Xiang Wei 
Published: July 2021

Abstract
The dynamic building foundation settlement subsidence are threatening the urban business and residential communities. In the temporal domain, the building foundation settlement often suffers from high level dynamics and needs real-time monitoring. Accurate quantification of the uncertainty of foundation settlement in the near future is essential for the in-advance risk management for buildings. Traditional models for predicting foundation settlement mostly utilizing the point estimates approach which provide a single value that can be close or distant from the actual one. However, such estimation fails to offer the quantification of uncertainties of estimation. The interval prediction, as an alternative, can provide a prediction interval for the ground settlement with high confidence bands. In this paper, a lower upper bound estimation (LUBE) approach integrated with kernel based extreme learning machine (KELM) is proposed to predict the ground settlement levels with prediction intervals in the temporal domain. Comparison with the artificial neural network (ANN) and classical extreme learning machine (ELM) are conducted in this study. Building settlement data collected from Fuxing City, Liaoning Province in China has been used to validate the proposed approach. Comparative results show that the proposed approach can construct higher quality prediction intervals for the future foundation settlement.
Seasonal Variation Imparts The Endophytic Bacterial Community Dynamics in Mango Plants and Its Hemiparasites
Authors: Adhikary Rajsekhar , Mandal Sukhendu , Mandal Vivekananda 
Published: July 2021

Abstract
Assessment of bacterial community dynamics helps to estimate the endophytic community structure and ecological behaviour imposed by them. Such community composition is essential to understand the molecular interplay that lies between them and the host plants. The present study aims to explore the endophytic bacterial communities and their dynamics in the pre-flowering and post-flowering seasons in the horticulturally important Mango (Mangifera indica L.) and its hemiparasites Loranthus sp., and Macrosolen sp. through a metagenomic approach using the sequence of V3 region of 16S rRNA gene. Bacillus was found to be the most abundant genera, followed by Acinetobacter, and Corynebacterium, which belong to the phyla Firmicutes, Proteobacteria, and Actinobacteria. It has been found that during the post-flowering season, twigs and leaves of mango have lower endophytic bacterial loads. Furthermore, the alpha-diversity indices of the representative genera were highest in Loranthus sp. during the post-flowering seasons of mango. The ecological, taxonomic, and complex correlation studies unravelled that the hemiparasites act as the potent reservoirs of endophytic community throughout the year, and during favourable conditions, these bacterial communities disseminate to the mango plant.
A Pilot Study Evaluating the Development and Implementation of a Feasible, Evidence-based, Group Cognitive Training Program Within an Older People’s Mental Health Service
Authors: Woolf Claudia , Gately Danielle , Kaplan Leanne , Shahnawaz Zeeshan , Norrie Louisa Margaret , Burke David , Naismith Sharon Linda , Mowszowski Loren 
Published: July 2021

Abstract
Background and objectivesIn the absence of a cure for dementia, investigation of novel strategies aimed at delaying or preventing the onset of dementia are gaining momentum. In this regard, using the RE-AIM framework, we outline steps taken to adapt and implement an evidence-based cognitive training program for older adults ‘at risk’ of developing dementia within a clinical setting of a major metropolitan hospital. The primary aim was to explore feasibility (or ‘reach’), tolerability (or ‘implementation’), and acceptability (or ‘adoption’). The secondary aim was to explore the most sensitive clinical outcomes and measurement tools (i.e. ‘efficacy’) to inform a subsequent formal feasibility randomised controlled trial. MethodThis was an exploratory feasibility pilot study, using a pre-post single-arm study design. We conducted this study within the Older People’s Mental Health Service at St Vincent’s Hospital, Sydney, Australia. Seventy-nine participants, with a mean age of 78 years (SD=5.8, range=67-94) were enrolled. All enrolled participants engaged in ‘Club Connect’ an adaptation of a 10-week, group-based multifaceted program, comprised of psychoeducation and computer-based cognitive training. At baseline and follow-up, all participants completed a battery of neuropsychological tests and several questionnaires related to mood and psychosocial functioning. ResultsImplementing cognitive training within a clinical setting was feasible, well tolerated and accepted by participants. Further, cognitive training was associated with large to very large effect size improvements in verbal learning, memory for verbal and visual information, and semantic fluency, as well as quality of life, and reductions in anxiety and stress. We also found small to medium effect size improvements for other cognitive and psychosocial outcomes. ConclusionsOur preliminary findings support the feasibility of translating a group-based cognitive training program into the clinical setting, and provide key data to facilitate the next phase of implementation.
Effective Adsorption of Nutrients from Simulated Domestic Sewage by Modified Maifanite
Authors: Liu Zisen , Zou Yilingyun , Liu Yunli , Luo Feng , Wang Rou , WU Zhenbin , Zhang Yi 
Published: July 2021

Abstract
Modified maifanite (MMF) was prepared by synthesized method with sulfuric acid treatment and high temperature calcination, and evaluated as an effective adsorption material to remove the nutrient salt in waste watery. Compared with the raw maifanite (RMF), the MMF exhibited the higher adsorption capacity and higher removal efficiency. The results showed that the adsorption rates of total phosphorus (TP), total nitrogen (TN), ammonia nitrogen (NH3-N), nitrate nitrogen (NOx-N) and Chemical Oxygen Demand (COD) by MMF (RMF) were86.7% (76.7%), 44.9% (34.5%), 29.1% (20.8%) and 79.8% (13.0%) respectively at 20 ℃ for 24 h. MMF kept the basic structure and composition of maifanite with stronger surface roughness and more adsorption active sites. This study suggests that MMF can be further applied to treat domestic sewage and eutrophic water.
Prognostic Impact of Postoperative Systemic Inflammatory Response in Patients with Stage II/III Gastric Cancer
Authors: Kuroda Kenji , Toyokawa Takahiro , Miki Yuichiro , Yoshii Mami , Tamura Tatsuro , Tanaka Hiroaki , Lee Shigeru , Muguruma Kazuya , Yashiro Masakazu , Ohira Masaichi 
Published: July 2021

Abstract
Background: Several studies have shown that postoperative infectious complications correlate with poor prognosis in various malignancies, but the prognostic significance of the postoperative inflammatory response in patients with gastric cancer remains unclear. This study examined whether the systemic inflammatory response present in the early phase of the postoperative state correlates with long-term outcomes and to identify markers in patients with stage II/III gastric cancer.Methods: This study retrospectively reviewed 444 consecutive patients who underwent radical gastrectomy for stage II/III gastric cancer. We evaluated maximum serum C-reactive protein (CRPmax) and white blood cell count (WBCmax), defined as the maximum serum CRP level and maximum WBC count during the interval from surgery until discharge, as systemic inflammation markers.Results: In univariate analyses, CRPmax, WBCmax and infectious complications were significantly associated with both overall survival (OS) (p<0.001, p<0.001 and p=0.011, respectively) and relapse-free survival (RFS) (p<0.001, p=0.001 and p<0.001, respectively). Multivariate analysis revealed that high-CRPmax (>9.2 mg/dL) was an independent prognostic factor for OS (hazard ratio (HR) 1.69, 95% confidence interval (CI) 1.18–2.42, p=0.004) and RFS (HR 1.42, 95%CI 1.02–1.98, p=0.038), while WBCmax and infectious complications were not. Conclusion: CRPmax, which reflects the magnitude of systemic inflammation induced by surgical stress and postoperative complications in the early phase after surgery, may be a promising prognostic indicator in patients with stage II/III gastric cancer who undergo curative resection.