bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Music Intervention on COVID-19 Patients with Mental Disorders: A Protocol for a Systematic Review and Meta-analysis
Authors: Peng Sihan , Xie Ziyan , Zhang Xiyu , Xie Chunguang , Kang Jian , Yuan Haipo , Xu Gang , Zhang Xiangeng , Liu Ya 
Published: May 2021

Abstract
Background: The COVID-19 pandemic caused by the SARS-CoV-2 virus is a major health crisis that is affecting countries across the world. Patients infected with COVID-19 are often associated with mental health disorders, such as anxiety, depression, and sleep disorders. As a non-drug therapy applied in clinics for many years, music intervention is safe, effective, inexpensive, and devoid of side effects. Yet, there is a distinct lack of evidence to support the use of this technique. In this study, we aim to collect and evaluate the clinical evidence, in order to provide a basis for the efficacy and safety of music intervention in the treatment of COVID-19 patients with mental disorders.Methods: We plan to search a range of electronic databases from inception to the May 2021, including PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang Database, Chinese Biomedical Literature Database, and Chinese Science and Technology Periodical Database (VIP). All randomized controlled trials featuring music intervention to treat mental disorders such as anxiety, depression, or sleep disorders, for patients with COVID-19, will be included. The primary outcomes will be quantitative scores for anxiety, depression, and sleep disorder. The secondary outcomes will be quality of life and the safety profile of music intervention, including adverse events. Two reviewers will carry out the selection of studies, data extraction independently. The Cochrane risk of bias tool will be used to evaluate the risk of bias for the studies. We will use Review Manager V.5.3 software for data analysis. Subgroup analyses and sensitivity analyses are planned to assess the heterogeneity and reliability.Discussion: This is an up-to-date systematic review and meta-analysis of the efficacy and safety of music intervention on mental disorders (anxiety, depression, or sleep disorder) in COVID-19 patients, in order to provide clinicians, researchers, and policy makers, with powerful reference guidelines to facilitate treatment and improve the quality of life in COVID-19 patients with mental disorders.Systematic review registration: OSF 10.17605/OSF.IO/9RCX5
Changes in Child Undernutrition and Overweight in India from 2006 to 2019: An Analysis of 22 States
Authors: Varghese Jithin Sam , Gupta Aashish , Mehta Rukshan , Stein Aryeh D. , Patel Shivani A. 
Published: May 2021

Abstract
Objectives: India has historically displayed high levels of child stunting and low levels of child overweight. Using newly released data, we evaluated changes in priority indicators of child growth from 2006 to 2019 and examined the role of human development measures in these changes. Methods: We estimated cumulative and annualized changes in state- and district-level child growth indicators using three rounds of National Family Health Surveys (2005-06, 2015-16, 2019-20) in 22 states. Outcomes included stunting, underweight, wasting, and overweight. Human development was measured using a principal components analysis of nine survey-based items. We contrasted expected versus observed changes in district-level growth indicators between 2015 and 2019 based on changes in development measures using two-way Blinder Oaxaca decomposition. Results: From 2006 to 2019, the prevalence of stunting and underweight decreased by 10.9 percentage points (pp) and 7.1 pp, respectively, while the prevalence of wasting and overweight increased by 2.8 pp and 2.2 pp, respectively. Annualized rates of change for stunting, wasting, and underweight were lower from 2015 to 2020 compared with the 2006 to 2015 period, while rates of change in overweight were higher. Simultaneously, all nine human development indicators improved between 2006 and 2020. A unit increase between 2015 and 2020 in the human development score predicted a -4.7 pp (95% CI: - 5.7, -3.6) change in stunting, yet stunting declined by just -0.3 pp. Conclusions: Population-level reductions in child undernutrition have stalled and the rise in child overweight has accelerated between 2015 and 2020 relative to the 10 years preceding this period.
suPAR Cut-offs for Stratification of Low, Medium, and High-risk Acute Medical Patients in the Emergency Department
Authors: Seppälä Santeri , Andersen Andreas Peter , Nyyssönen Kristiina , Eugen-Olsen Jesper , Hyppölä Harri 
Published: May 2021

Abstract
Background: Soluble urokinase plasminogen activator receptor (suPAR) levels have previously been associated with readmission and mortality in acute medical patients in the ED. However, no specific cut-offs for suPAR has been tested in this population. Methods: Prospective observational study of acute medical patients. Follow-up of mortality and readmission was carried out for 30- and 90 days stratified into baseline suPAR < 4, 4-6 and > 6 ng/ml. suPAR levels were measured using suPARnostic® Turbilatex assay on a Cobas c501 (Roche Diagnostics Ltd) analyser. Results: A total of 1747 acute medical patients in the ED were included. Median age was 70 (IQR: 57-79) and 51.4% were men. Cox regression analysis showed that suPAR, independently of age, sex and C-reactive protein levels, predicted 30- and 90-day mortality (both p<0.001). Among patients with suPAR below 4 ng/ml (N=804, 46.0%), 8 (1.0%) died within 90-day follow-up, resulting in a negative predictive value of 99.0% and a sensitivity of 94.6%. Altogether 514 (29.4%) patients had suPAR4-6 ng/ml, of whom 43 (8.4%) died during 90-day follow-up. Among patients with suPAR above 6 ng/ml (N=429, 24.6%), 87 patients (20.3%) died within 90-day follow-up, resulting in a positive predictive value of 20.1% and a specificity of 78.7%. Conclusions: suPAR cut-offs of below 4, between 4-6 and above 6 ng/ml can identify acute medical patients who have low, medium or high risk of 30- and 90-day mortality. The turbidimetric assay provides fast suPAR results that may aid in the decision of discharge or admission of acute medical patients.
Early Development of The Trunk Neural Crest Cells in the Egyptian Cobra Naja H. Haje
Authors: Khannoon Eraqi R. , Alvarado Christian , de Bellard Maria Elena Elena 
Published: May 2021

Abstract
Background: Trunk neural crest cells (TNCC) are representing a model for epithelial to mesenchymal transition, this correlates the importance of studying the migration of these cells to cancer metastasis. Reptiles are unique group of animals being very morphologically diverse and their close position to synapsid leading to mammals. Recently, more publications focused on the migratory behavior of trunk NCC during embryonic development of squamates. Only one colubrid snake has been studied so far regarding the NCC migration. Results: Here we follow the migratory behavior of TNCC with HNK1 in the elapid snake Naja h. haje from early stage to 14 days postoviposition. Comparing the colubrid snake with the Egyptian cobra showed that both snakes overall follow the same TNCC migratory pathways of both birds and mammals by following the rostral and avoiding the caudal portions of the somites. Conclusions: First, TNCC intra-somitic migration as observed in turtles supports a contributing role for TNCC to scale precursors. Second, our observation of significant numbers of migrating TNCC in the intersomitic pathway suggest interesting evolutionary differences. Together, our present results of the Egyptian cobra in combination with those on a colubrid and turtle supports intersomitic TNCC as a unique reptile phenomena.
Geosmithia Species Associated With Bark Beetles From Southern China, With the Description of Four New Species
Authors: Zhang Xiuyu , Li You , Dai Meixue , Si Hongli , Zhao Guoyan , Kolařík Miroslav , Hulcr Jiri , Jiang Xiaoqian , Chang Runlei 
Published: May 2021

Abstract
Fungi of the genus Geosmithia are frequently associated with bark beetles that feed on phloem on various woody hosts. Most studies on Geosmithia were carried out in North and South America and Europe, with only two species were reported from Taiwan, China. The aim of this study was to investigate the diversity of Geosmithia species in southern China. Field surveys in Guangdong, Guangxi, Hunan, Jiangxi and Shanghai yielded a total of 76 fungal isolates from six beetle species. Isolates were grouped based on morphology. The ITS, β-tubulin and elongation factor 1-α gene regions of representatives of each group were sequenced. Phylogenetic trees were constructed based on those sequences. In total five species were identified, with one previously described species G. putterillii and four new species which were described as G. jiulianshanensis, G. jiangxiensis, G. formosana, and G. pulverea (Geosmithia sp. 3 and Geosmithia sp. 23) sp. nov., in this paper.
Potato (Solanum tuberosum L.) technology development and promotion for sustainable food security and commercialization in Awi zone, Northwestern Ethiopia
Authors: Getahun Addisu 
Published: May 2021

Abstract
Potato is one of the most important highland crops that highly contribute to food security in different parts of Ethiopia as well as in the world. A major constraint for potato production and productivity includes lack of high yielding varieties, low soil fertility, poor crop management practice, drought, Insect pest, diseases, weeds, poor post-harvest handling techniques, and poor linkages of value chain actors, low dry matter and starch content. The major objectives of this project are to introduce best-performed genotypes with good pest resistance, improve potato cultivation techniques with appropriate agronomic practices, to identify and manage major pests of potato and their effects on yield loss, analyses potato value chain actors and production economics, evaluate post-harvest handling of potato. The project will be carried out using different experimental designs (Randomized Complete Block Design, split plot, lattice arrangement, single plot), sampling methods (random and systematic sampling techniques), both qualitative and quantitative data will be collected and analysed using different statistical software packages (SAS, SPSS, Genstat, PBTools).
Cryptosporidium spp. infections in livestock and wild animals in Azerbaijan territory
Authors: Mamedova S. , Karanis P. 
Published: May 2021

Abstract
Cryptosporidium is an intracellular protozoan parasite, globally distributed and capable of infecting various vertebrate species, including humans as well as domestic and wild animals. Cryptosporidium is increasingly gaining attention as a human and an animal pathogen mainly due to its dominant involvement in worldwide waterborne outbreaks. The present paper reviews the current knowledge and understanding of Cryptosporidium spp. in terrestrial and water animals in Azerbaijan.
Microbial faecal pollution of river water in a watershed of tropical Ethiopian highlands is driven by diffuse pollution sources
Authors: Mushi Douglas , Kebede Geda , Linke Rita B. , Lakew Aschalew , Hayes Daniel S. , Graf Wolfram , Farnleitner Andreas H. 
Published: May 2021

AbstractTropical communities in the developing world depend heavily on riverine systems for their socioeconomic development. However, these resources are poorly protected from diffuse pollution, and there is a lack of quantitative information regarding the microbial pollution characteristics of riverine water, despite frequently reported gastrointestinal diseases. The aim of our study was to apply faecal taxation (i.e., faecal pellet counting in representative test areas to estimate the potential availability of diffuse pollution sources) in combination with a detailed microbiological faecal pollution analysis in a riverine environment to elucidate the importance of diffuse pollution. To realize this approach, ambient faecal pellets, a multiparametric data set for standard faecal indicator bacteria (SFIB), including Escherichia coli, Clostridium perfringens spores and enterococci from catchment soil and river water, and a number of riverine water physicochemical variables were analysed during a one-year cycle. We demonstrated that the abundance of ambient faecal pellets, which were consistently counted at reference sites in the catchment, was associated with faecal pollution in the river water. Water SFIB, dissolved oxygen, nutrients, conductivity and total suspended solids were strongly linked with the abundance of ambient faecal pellets in the river catchment, as demonstrated by principal component analysis (PCA). Elevated concentrations of SFIB in the riverine water in the absence of rainfall also suggested the direct input of faecal bacteria into the riverine water by livestock (e.g., during watering) and humans (e.g., during bathing). Statistical analyses further revealed that the microbiological water quality of the investigated riverine water was not influenced by SFIB potentially occurring in the soil. This study demonstrates the importance of diffuse faecal pollution sources as major drivers of the microbiological quality of riverine water in the Ethiopian highlands. In addition, the new successfully applied integrated approach could be very useful for developing predictive models, which would aid in forecasting riverine microbiological quality in tropical developing countries.
Poważny brak rozeznania oceniającego (kan. 1095, n. 2 KPK) w wyroku Roty Rzymskiej c. Salvatori z 7 maja 2020 roku
Authors: Góralski Wojciech 
Published: May 2021

The negative sentence c. Salvatori in the case under the gravis defectus discretionis iudicii (can. 1095, n. 2 CIC) on both sides, taken in the second instance, when the first ruled positively in relation to both parties, is an example of a reliable assessment of the collected material evidence.
In the sentence, quite a lot of space was devoted to the role and tasks of an expert in the cases of can. 1095, n. 1-3 CIC. It is worth emphasizing here that an opinion prepared solely on the basis of the case file is not a true expert opinion. Salvatori pointed to the practice developed in rotational jurisprudence, according to which a judge should reject an expert’s conclusions when they do not comply with the case files or violate the rules of logic or go beyond the premises on which they are based, or when they are inconsistent with Christian anthropology.
Ponens convincingly demonstrated the groundlessness of prof. D. (with respect to the woman) grossly inconsistent with the case files and going far beyond the premises that served him to formulate such a thesis.
Protective Effects of Curcumin against Lipopolysaccharide-Induced Toxicity
Authors: Ganji Ali , Farahani Iman , Saeedifar Amir Mohammad , Mosayebi Ghasem , Ghazavi Ali , Majeed Muhammed , Jamialahmadi Tannaz , Sahebkar Amirhossein 
Published: May 2021

Background:
Lipopolysaccharide (LPS), a Gram-negative bacterial cell wall
component, evokes intensive inflammatory responses in the human body. Naturally, inflammation
is a part of the host immune response to an infection; nonetheless, an exaggerated
response can lead to a series of pathophysiological consequences, collectively
known as LPS toxicity or septic shock.

Objective:
This review will explore the cellular and experimental investigations that
mainly focus on Curcumin's therapeutic effects on the LPS-mediated inflammatory responses.

Method:
A literature review of all relevant studies was performed.

Conclusion:
Curcumin has been reported to exert anti-inflammatory properties by interfering
with LPS-induced inflammatory pathways, including binding to cell surface receptors
of LPS, NF-kB activation pathway, and inflammasome activation. Further clinical
studies on the effect of Curcumin in reducing the pathophysiological consequences of
LPS toxicity would substantiate the use of this molecule for future therapeutic approaches.
Hemoglobin F (HbF) Inducers; History, Structure and Efficacies
Authors: Hashemi Zahra , Ebrahimzadeh Mohammad Ali 
Published: May 2021

Abstract:Inherited beta-thalassemia is caused by irregular production of hemoglobin through reducing beta-globin chains. It has been observed that increasing fetal hemoglobin (HbF) production improves symptoms in the patients; thus, it has been an operative approach to treat patients with betathalassemia. This review represents compounds with biological activities and pharmacological properties that can be useful in promoting the HBF level in β-thalassemia patients. Various natural products with different mechanisms of action can be helpful in this medication cure. Clinical trials were efficient in improving the signs of patients. Association of in vivo, and in vitro studies of HbF induction and γ-globin mRNA growth displays that in vitro experiments could be an indicator of the in vivo response. The current study resulted that; (a) HbF inducers can be grouped into several classes based on their chemical structures and mechanism of actions; (b) According to several clinical trials, wellknown drugs such as hydroxyurea and decitabine are useful HbF inducers. (c) The cellular biosensor K562 carrying genes under the control of the human γ-globin and β-globin gene promoters were applied during the researches. (d) New natural products and lead compounds were found based on various studies as HbF inducers.
Progress and Development of C-3, C-6, and N-9 Positions Substituted Carbazole
Integrated Molecular Hybrid Molecules as Potential Anticancer
Agents
Authors: Luthra Pratibha Mehta , Kumar Nitin 
Published: May 2021

Abstract:
The carbazole skeleton, a key structural motif occurring naturally or chemically synthesized,
showed various biological activities. Molecular hybridization based on the combination of two
or more bioactive pharmacophores has been an important tool to convert the potent structural leads to
form new hybrid compounds with improved biological activity. In recent years, modifications/
substitutions of the carbazole motif at C-3, C-6, and N-9 positions have been carried to develop
novel carbazole-based potential anticancer agents in the therapy of cancer. In the last fifteen years,
several compounds based on carbazole core integrated into pharmacologically active molecular hybrid
having active pharmacophore such as1,3,4-thiadiazole, thiazole, guanidine, sulfonamides, glyoxamides,
imidazoles, phenanthrenes, rhodamines, chalcones, imidazopyridine, platinum, 2-H-chromen-
2-one, hydrazones, piperazines, isoxazole-thiadiazole, pyrazoles, etc. have been synthesized showing
anticancer profile at sub-micromolar to nano-molar concentrations. We have thoroughly reviewed the
design, progress, and development of C-3, C-6, and N-9 positions substituted carbazole derivatives
integrated with various medicinally active pharmacophore as potential anticancer agents evaluated
against various cancer cell lines. Additionally, the anticancer mechanism and in vivo activity of the
reported compounds have been discussed. This study will support in designing of new pharmacophore
that can be linked to the carbazole motif for the development of new, potent, and target-specific anticancer
drugs with improved pharmacokinetics and minimal side effects.
Pituitary Volume in Patients with Primary Empty Sella and Clinical Relevance to Pituitary Hormone Secretion: A Retrospective Single Center Study
Authors: Akkus Gamze , Sözütok Sinan , Odabaş Fulya , Onan Bilen , Evran Mehtap , Karagun Barış , Sert Murat , Tetiker Tamer 
Published: May 2021

Background:
According to neuroradiological findings, empty sella seems to be deprived
of pituitary tissue in sella turcica. Changing size of the pituitary volume is closely related to the occurrence
of primary empty sella. The aim of the study is to determine pituitary dysfunction in patients
with partial or total primary empty sella and the significance of pituitary volume measurements
in these patients.

Methods:
This study was designed retrospectively. 67 patients (55 females, 12 males) diagnosed
with primary empty sella syndrome between the years of 2015-2019 were included in the study. Patients
were divided into two groups: partial (PES) and total (TES) empty sella by magnetic resonance
imaging (MRI). Basal anterior pituitary and its hormones were assessed. We also included
26 healthy control subjects (19 females, 7 males) to compare the differences in pituitary volumes.
Volumes were measured by using Osirix Dicom Viewer (Pixmeo SARL, Geneve, Swiss) in 3.0
Tesla scanner MRI.

Results:
82.1% (n=55) of all patients were PES and the others were (n=12) TES. Hypopituitarism,
known as one or more pituitary hormones deficiency, was found in 12 patients (17.9%). While 9 of
them had total PES, the others had partial PES. Secondary adrenal insufficiency and gonadotropin
deficiency were more prevalent in patients with TES. Mean volume measurements of patients with
TES, PES and healthy subjects were 0.23±0.17, 0.35±0.15, 0.54±0.17 cm3, respectively. Except for
IGF1 values (p=0.026), there was not any significant correlation found between the anterior pituitary
hormones and volume measurements.

Conclusion:
Although volume measurement has helped in the diagnosis of pituitary empty sella
(partial or total), it does not seem to have any significant correlation with pituitary secretory function.
Narrow-Bandgap Semiconductors of Perovskite Rare-Earth Orthoferrites (REFeO3)
Authors: Chen Lei , Jiang Ting , Zheng Guifang , Yao Gang , Wang Lei , Yang Yuanjun , Zheng Haiwu , Jiang Yang , Lu Yingwei , Wei Shizhong 
Published: May 2021

Background:
Great achievements have been made in improving the power conversion efficiencies
of solar cells. However, the price of photovoltaic (PV)-generated electricity still cannot compete
with that of conventionally generated power. Thus, novel solar cells made from non-toxic, earth-abundant,
and chemically stable materials are desirable to decrease the costs of PV electricity generation.

Objective:
All-oxide solar cells are a promising next-generation PV technology, fulfilling the requirement
of low-cost manufacturing under ambient conditions. This work aims to search for nontoxic,
earth-abundant, and chemically stable narrow-bandgap semiconductors for energy applications
like all-oxide solar cells.

Methods:
This work examines a family of perovskite rare-earth (i.e., Y, La, Ce, Pr, Nd, Sm, Gd, Tb,
Dy, Ho, Er, and Yb) orthoferrites with XRD analysis, SEM, photoresponse, absorption spectra, Xray
photoelectron spectroscopy, fluorescence spectra measured with the laser Raman spectrometer,
valence band spectra, the Kelvin probe, the Hall Effect experiment, and theoretical calculation on
band structure and the density of states, to screen for the narrow-bandgap semiconductors.

Results:
The novel Pb-free perovskite narrow-bandgap absorbers, CeFeO3, PrFeO3, TbFeO3,
DyFeO3, HoFeO3, and YbFeO3, which are earth-abundant and non-toxic, were screened out potentially
for use in all-oxide solar cells or other photovoltaic and optoelectronic applications. Among
them, YbFeO3 is approved, having an indirect bandgap of approximately 1.0 eV with a maximum
Shockley-Queisser efficiency of 31% for single p-n junction solar cells.

Conclusion:
The chemically stable, non-toxic, earth-abundant, and narrow-bandgap semiconductors
of rare-earth orthoferrites promisingly serve as absorbers, photocatalysts, photoelectrodes, photodetectors,
and photoelectronic materials. This work breaks new ground in the search for narrow
bandgap all-oxide semiconductors potential for energy applications.