bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrieving 2-D laterally varying structures from multistation surface wave dispersion curves using multiscale window analysis
Authors: Hu Shufan , Zhao Yonghui , Socco Laura Valentina , Ge Shuangcheng 
Published: July 2021

SUMMARY
The analysis of multistation surface wave records is of increasing popularity in imaging the structure of the Earth due to its robustness on dispersion measurement. Since the representation of multistation surface wave dispersion curves (DCs) is uncertain in laterally varying media, average information beneath the receiver array is assumed to be obtained by inverting the dispersion curves with a horizontally layered model. To retrieve a more realistic 2-D laterally varying structure, we present a multiscale window analysis of surface waves (MWASW) method for analysing 2-D active-source surface wave data. The MWASW method is based on the use of a forward algorithm for calculating the theoretical DCs over 2-D models and multisize spatial windows for estimating the dispersion data. The forward algorithm calculates the theoretical dispersion considering the lateral variation beneath the receiver array; hence, the estimated DC is not treated as representative of the average properties but as data containing the lateral variation information. By inverting the dispersion data extracted from different spatial windows, the subsurface information at different depth ranges and lateral extensions are integrated to produce a shear wave velocity model. The dispersion curves analysed from smaller spatial windows retrieve the shallow structure with a higher lateral resolution, whereas the phase velocity data from larger spatial windows provide average information with a greater depth. We test the effectiveness of the MWASW method using three synthetic examples and two field data sets. Both results show the improved lateral resolution of the S-wave velocity structure retrieved with the MWASW method compared to the traditional multistation method in which the local horizontally layered model is adopted.
COVID-19 Preparedness and Response Plans from 106 countries: a review from a health systems resilience perspective
Authors: Mustafa Saqif , Zhang Yu , Zibwowa Zandile , Seifeldin Redda , Ako-Egbe Louis , McDarby Geraldine , Kelley Edward , Saikat Sohel 
Published: July 2021

Abstract
Coronavirus disease (COVID-19) has exposed long-standing fragmentation in health systems strengthening efforts for health security and universal health coverage while these objectives are largely interdependent and complementary. In this prevailing background, we reviewed countries’ COVID-19 Preparedness and Response Plans (CPRPs) to assess the extent of integration of non-COVID-19 essential health service continuity considerations alongside emergency response activities. We searched for COVID-19 planning documents from governments and ministries of health, World Health Organization (WHO) country offices and United Nations (UN) country teams. We developed document review protocols using global guidance from the WHO and UN and the health systems resilience literature. After screening, we analysed 154 CPRPs from 106 countries. The majority of plans had a high degree of alignment with pillars of emergency response such as surveillance (99%), laboratory systems (96%) and COVID-19-specific case management (97%). Less than half considered maintaining essential health services (47%); 41% designated a mechanism for health system–wide participation in emergency planning; 34% considered subnational service delivery; 95% contained infection prevention and control (IPC) activities and 29% considered quality of care; and 24% were budgeted for and 7% contained monitoring and evaluation of essential health services. To improve, ongoing and future emergency planning should proactively include proportionate activities, resources and monitoring for essential health services to reduce excess mortality and morbidity. Specifically, this entails strengthening subnational health services with local stakeholder engagement in planning; ensuring a dedicated focus in emergency operations structures to maintain health systems resilience for non-emergency health services; considering all domains of quality in health services along with IPC; and building resilient monitoring capacity for timely and reliable tracking of health systems functionality including service utilization and health outcomes. An integrated approach to planning should be pursued as health systems recover from COVID-19 disruptions and take actions to build back better.
Effective therapeutic strategies in a preclinical mouse model of Charcot–Marie–Tooth disease
Authors: Nuevo-Tapioles Cristina , Santacatterina Fulvio , Sánchez-Garrido Brenda , de Arenas Cristina Núñez , Robledo-Bérgamo Adrián , Martínez-Valero Paula , Cantarero Lara , Pardo Beatriz , Hoenicka Janet , Murphy Michael P , Satrústegui Jorgina , Palau Francesc , Cuezva José M 
Published: July 2021

AbstractCharcot–Marie–Tooth (CMT) disease is a neuropathy that lacks effective therapy. CMT patients show degeneration of peripheral nerves, leading to muscle weakness and loss of proprioception. Loss of mitochondrial oxidative phosphorylation proteins and enzymes of the antioxidant response accompany degeneration of nerves in skin biopsies of CMT patients. Herein, we followed a drug-repurposing approach to find drugs in a Food and Drug Administration-approved library that could prevent development of CMT disease in the Gdap1-null mouse model. We found that the antibiotic florfenicol is a mitochondrial uncoupler that prevents the production of reactive oxygen species and activates respiration in human GDAP1-knockdown neuroblastoma cells and in dorsal root ganglion neurons of Gdap1-null mice. Treatment of CMT-affected Gdap1-null mice with florfenicol has no beneficial effect in the course of the disease. However, administration of florfenicol, or the antioxidant MitoQ, to pre-symptomatic GDAP1-null mice prevented weight gain and ameliorated the motor coordination deficiencies that developed in the Gdap1-null mice. Interestingly, both florfenicol and MitoQ halted the decay in mitochondrial and redox proteins in sciatic nerves of Gdap1-null mice, supporting that oxidative damage is implicated in the etiology of the neuropathy. These findings support the development of clinical trials for translation of these drugs for treatment of CMT patients.
Pricing in make-to-order firms with a lead time-dependent cost
Authors: Cai Xiaoli , Li Jun 
Published: July 2021

Abstract
The existing literature on make-to-order firms typically supposes that the unit production cost is a constant. In contrast, in this study, this cost is a variable that depends on the lead time. Under this assumption, we investigate the pricing problem for both a monopoly firm and two competing firms. Specifically, we develop a queueing-game-theoretic model to capture the interaction between customers and the firm’s manager and further solve the pricing problem. The results illustrate that, for a monopoly firm, there exists a service rate threshold, and for two homogeneous firms, there is a unique symmetric equilibrium. However, for two heterogeneous firms, the equilibrium may not exist, and if it does, it may not be unique. In this case, the equilibrium is characterized analytically if it is unique and explored numerically if not. Finally, a specific cost function is adopted to analyse the sensitivity of the optimal decisions. When the firms have this variable cost, compared with those with constant unit production cost, customers’ waiting time might be shorter, and the competition between firms might be fiercer. Also, for these firms, increasing the service rate or decreasing the cost parameter does not always help to increase their market share or profit.
Engineering and standardization of posttranscriptional biocircuitry inSaccharomyces cerevisiae
Authors: McCarthy John 
Published: July 2021

AbstractThis short review considers to what extent posttranscriptional steps of gene expression can provide the basis for novel control mechanisms and procedures in synthetic biology and biotechnology. The term biocircuitry is used here to refer to functionally connected components comprising DNA, RNA or proteins. The review begins with an overview of the diversity of devices being developed and then considers the challenges presented by trying to engineer more scaled-up systems. While the engineering of RNA-based and protein-based circuitry poses new challenges, the resulting ‘toolsets’ of components and novel mechanisms of operation will open up multiple new opportunities for synthetic biology. However, agreed procedures for standardization will need to be placed at the heart of this expanding field if the full potential benefits are to be realized.
Determining fundamental parameters of detached double-lined eclipsing binary systems via a statistically robust machine learning method
Authors: Remple Bryce A , Angelou George C , Weiss Achim 
Published: July 2021

ABSTRACT
The parameter space for modelling stellar systems is vast and complicated. To find best-fitting models for a star one needs a statistically robust way of exploring this space. We present a new machine-learning approach to predict the modelling parameters for detached double-lined eclipsing binary systems, including the system age, based on observable quantities. Our method allows for the estimation of the importance of several physical effects which are included in a parametrized form in stellar models, such as convective core overshoot or stellar spot coverage. The method yields probability distribution functions for the predicted parameters which take into account the statistical and, to a certain extent, the systematic errors which is very difficult to do using other methods. We employ two different approaches to investigate the two components of the system either independently or in a combined manner. Furthermore, two different grids are used as training data. We apply the method to 26 selected objects and test the predicted best solutions with an on-the-fly optimization routine which generates full hydrostatic models. While we do encounter failures of the predictions, our method can serve as a rapid estimate for stellar ages of detached eclipsing binaries taking full account of the uncertainties in the observables.
SN 2019hcc: a Type II supernova displaying early O ii lines
Authors: Parrag Eleonora , Inserra Cosimo , Schulze Steve , Anderson Joseph , Chen Ting-Wan , Leloudas Giorgios , Galbany Lluis , Gutiérrez Claudia P , Hiramatsu Daichi , Kankare Erkki , Müller-Bravo Tomás E , Nicholl Matt , Pignata Giuliano , Cartier Regis , Gromadzki Mariusz , Kozyreva Alexandra , Rau Arne , Burke Jamison , Howell D Andrew , McCully Curtis , Pellegrino Craig 
Published: July 2021

ABSTRACT
We present optical spectroscopy together with ultraviolet, optical, and near-infrared photometry of SN 2019hcc, which resides in a host galaxy at redshift 0.044, displaying a sub-solar metallicity. The supernova spectrum near peak epoch shows a ‘w’ shape at around 4000 Å which is usually associated with O ii lines and is typical of Type I superluminous supernovae. SN 2019hcc post-peak spectra show a well-developed H α P-Cygni profile from 19 d past maximum and its light curve, in terms of its absolute peak luminosity and evolution, resembles that of a fast-declining Hydrogen-rich supernova (SN IIL). The object does not show any unambiguous sign of interaction as there is no evidence of narrow lines in the spectra or undulations in the light curve. Our tardis spectral modelling of the first spectrum shows that carbon, nitrogen, and oxygen (CNO) at 19 000 K reproduce the ‘w’ shape and suggests that a combination of non-thermally excited CNO and metal lines at 8000 K could reproduce the feature seen at 4000 Å. The Bolometric light-curve modelling reveals that SN 2019hcc could be fit with a magnetar model, showing a relatively strong magnetic field (B &gt; 3 × 1014 G), which matches the peak luminosity and rise time without powering up the light curve to superluminous luminosities. The high-energy photons produced by the magnetar would then be responsible for the detected O ii lines. As a consequence, SN 2019hcc shows that a ‘w’ shape profile at around 4000 Å, usually attributed to O ii, is not only shown in superluminous supernovae and hence it should not be treated as the sole evidence of the belonging to such a supernova type.
Core promoter activity contributes to chromatin-based regulation of internal cryptic promoters
Authors: Lee Bo Bae , Woo Hyeonju , Lee Min Kyung , Youn SeoJung , Lee Sumin , Roe Jae-Seok , Lee Soo Young , Kim TaeSoo 
Published: July 2021

Abstract
During RNA polymerase II (RNA Pol II) transcription, the chromatin structure undergoes dynamic changes, including opening and closing of the nucleosome to enhance transcription elongation and fidelity. These changes are mediated by transcription elongation factors, including Spt6, the FACT complex, and the Set2-Rpd3S HDAC pathway. These factors not only contribute to RNA Pol II elongation, reset the repressive chromatin structures after RNA Pol II has passed, thereby inhibiting aberrant transcription initiation from the internal cryptic promoters within gene bodies. Notably, the internal cryptic promoters of infrequently transcribed genes are sensitive to such chromatin-based regulation but those of hyperactive genes are not. To determine why, the weak core promoters of genes that generate cryptic transcripts in cells lacking transcription elongation factors (e.g. STE11) were replaced with those from more active genes. Interestingly, as core promoter activity increased, activation of internal cryptic promoter dropped. This associated with loss of active histone modifications at the internal cryptic promoter. Moreover, environmental changes and transcription elongation factor mutations that downregulated the core promoters of highly active genes concomitantly increased their cryptic transcription. We therefore propose that the chromatin-based regulation of internal cryptic promoters is mediated by core promoter strength as well as transcription elongation factors.
Does the Modified Arrhenius Model Reliably Predict Area of Tissue Ablation After Magnetic Resonance-Guided Laser Interstitial Thermal Therapy for Pediatric Lesional Epilepsy?
Authors: Cobourn Kelsey D , Qadir Imazul , Fayed Islam , Alexander Hepzibha , Oluigbo Chima O 
Published: July 2021

Abstract

BACKGROUND
Commercial magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) systems utilize a generalized Arrhenius model to estimate the area of tissue damage based on the power and time of ablation. However, the reliability of these estimates in Vivo remains unclear.

OBJECTIVE
To determine the accuracy and precision of the thermal damage estimate (TDE) calculated by commercially available MRgLITT systems using the generalized Arrhenius model.

METHODS
A single-center retrospective review of pediatric patients undergoing MRgLITT for lesional epilepsy was performed. The area of each lesion was measured on both TDE and intraoperative postablation, postcontrast T1 magnetic resonance images using ImageJ. Lesions requiring multiple ablations were excluded. The strength of the correlation between TDE and postlesioning measurements was assessed via linear regression.

RESULTS
A total of 32 lesions were identified in 19 patients. After exclusion, 13 pairs were available for analysis. Linear regression demonstrated a strong correlation between estimated and actual ablation areas (R2 = .97, P < .00001). The TDE underestimated the area of ablation by an average of 3.92% overall (standard error (SE) = 4.57%), but this varied depending on the type of pathologic tissue involved. TDE accuracy and precision were highest in tubers (n = 3), with average underestimation of 2.33% (SE = 0.33%). TDE underestimated the lesioning of the single hypothalamic hamartoma in our series by 52%. In periventricular nodular heterotopias, TDE overestimated ablation areas by an average of 13% (n = 2).

CONCLUSION
TDE reliability is variably consistent across tissue types, particularly in smaller or periventricular lesions. Further investigation is needed to understand the accuracy of this emerging minimally invasive technique.
Volatility-of-Volatility Risk in Asset Pricing
Authors: Chen Te-Feng , Chordia Tarun , Chung San-Lin , Lin Ji-Chai 
Published: July 2021

Abstract
This paper develops a general equilibrium model and provides empirical support that the market volatility-of-volatility (VOV) predicts market returns and drives the time-varying volatility risk. In asset pricing tests with the market, volatility, and VOV as factors, the risk premium on VOV is statistically and economically significant and robust. Market and volatility risks are not priced in unconditional models, but, consistent with theory, their factor loadings, conditional on VOV, are priced. The pricing impact of VOV strengthens during market crashes, suggesting that VOV is particularly relevant during market turmoil, when investors demand increased compensation for VOV risk. (JEL G11, G12, G13)
Negative overgeneralization is associated with anxiety and mechanisms of pattern completion in peripubertal youth
Authors: McMakin Dana L , Kimbler Adam , Tustison Nicholas J , Pettit Jeremy W , Mattfeld Aaron T 
Published: July 2021

Abstract
This study examines neural mechanisms of negative overgeneralization, the increased likelihood of generalizing negative information, in peri-puberty. Theories suggest that weak pattern separation [overlapping representations are made distinct, indexed by dentate gyrus/ cornu ammonis (CA)3 hippocampal subfield activation] underlies negative overgeneralization. We alternatively propose that neuro-maturational changes that favor pattern completion (cues reinstate stored representations, indexed by CA1 activation) are modulated by circuitry involved in emotional responding [amygdala, medial prefrontal cortices (mPFC)] to drive negative overgeneralization. Youth (n = 34, 9–14 years) recruited from community and clinic settings participated in an emotional mnemonic similarity task while undergoing magnetic resonance imaging. At study, participants indicated the valence of images; at test, participants made recognition memory judgments. Critical lure stimuli, which were similar to images at study, were presented at test, and errors (‘false alarms’) to negative relative to neutral stimuli reflected negative overgeneralization. Negative overgeneralization was related to greater and more similar patterns of activation in CA1 and both dorsal mPFC (dmPFC)and ventral mPFC (vmPFC) for negative relative to neutral stimuli. At study, amygdala exhibited greater functional coupling with CA1 and dmPFC during negative items that were later generalized. Negative overgeneralization is rooted in amygdala and mPFC modulation at encoding and pattern completion at retrieval.
Neurological Soft Signs Are Associated With Altered White Matter in Patients With Schizophrenia
Authors: Viher Petra Verena , Stegmayer Katharina , Bracht Tobias , Federspiel Andrea , Bohlhalter Stephan , Strik Werner , Wiest Roland , Walther Sebastian 
Published: July 2021

AbstractNeurological soft signs (NSS) are related to grey matter and functional brain abnormalities in schizophrenia. Studies in healthy subjects suggest, that NSS are also linked to white matter. However, the association between NSS and white matter abnormalities in schizophrenia remains to be elucidated. The present study investigated, if NSS are related to white matter alterations in patients with schizophrenia. The total sample included 42 healthy controls and 41 patients with schizophrenia. We used the Neurological Evaluation Scale (NES), and we acquired diffusion weighted magnetic resonance imaging to assess white matter on a voxel-wise between subject statistic. In patients with schizophrenia, linear associations between NES with fractional anisotropy (FA), radial, axial, and mean diffusivity were analyzed with tract-based spatial statistics while controlling for age, medication dose, the severity of the disease, and motion. The main pattern of results in patients showed a positive association of NES with all diffusion measures except FA in important motor pathways: the corticospinal tract, internal capsule, superior longitudinal fascicle, thalamocortical radiations and corpus callosum. In addition, exploratory tractography analysis revealed an association of the right aslant with NES in patients. These results suggest that specific white matter alterations, that is, increased diffusivity might contribute to NSS in patients with schizophrenia.
Signaled night awakening and its association with social information processing and socio-emotional development across the first two years
Authors: Mäkelä Tiina E , Kylliäinen Anneli , Saarenpää-Heikkilä Outi , Paavonen E Juulia , Paunio Tiina , Leppänen Jukka M , Peltola Mikko J 
Published: July 2021

Abstract

Study Objectives
Night awakening is common in infancy, and some infants continue to have signaled night awakenings throughout early childhood. However, the influence of signaled night awakening on children’s social development is less explored. In the present study, longitudinal associations between signaled night awakening, social information processing, and socio-emotional development were measured within the CHILD-SLEEP birth cohort in two groups formed based on parent-reported night awakenings.

Methods
At 8 months, there were 77 infants in the waking group (≥3 awakenings) and 69 infants in the nonwaking group (≤1 awakening). At 8 and 24 months, social information processing was measured as children’s attention to neutral and emotional faces, and at 24 months, parent-reported socio-emotional behavior was measured with the Brief Infant-Toddler Social and Emotional Assessment (BITSEA) questionnaire.

Results
The two groups showed different patterns of attention to emotional faces. The waking group had a more pronounced attentional bias to fearful versus happy faces, whereas in the nonwaking group, attention to fearful and happy faces did not differ. In addition, at 24 months, the waking group had more dysregulation problems and lower social competence than the nonwaking group, but no clear differences in internalizing or externalizing problems were found.

Conclusions
Our results contribute to the literature by showing that during the first 2 years of life, signaled night awakening is associated with social information processing and socio-emotional behavior.
An Accreditation Program to Produce Native Plant Nursery Stock Free of Phytophthora for Use in Habitat Restoration
Authors: Swiecki Tedmund J. , Bernhardt Elizabeth A. , Frankel Susan J. , Benner Diana , Hillman Janell 
Published: July 2021

Widespread Phytophthora infections have been discovered in nursery stock used in California restoration plantings. In response, Nursery Phytophthora Best Management Practices (NPBMPs) designed to exclude Phytophthora from nursery plants were developed to address the need for clean planting stock in restoration projects. A pilot program to implement the systematic use of the NPBMPs, Accreditation to Improve Restoration (AIR), was developed and started in 2018. As of 2020, 13 northern California restoration nurseries have been evaluated, and five have met all the program requirements. In 564 tests conducted over 4 years with a sensitive leachate baiting protocol, no Phytophthora was detected from over 20,000 nursery plants produced in compliance with the NPBMPs. In comparison, Phytophthora was detected in 25% of tests conducted on partially compliant stock and in 71% of tests from nurseries following few or no NPBMPs. The AIR pilot program has demonstrated that container stock free of detectable Phytophthora can be reliably produced by adhering to an integrated program of clean nursery production practices. To obtain Phytophthora-free plants for habitat restoration, informed clients were willing to pay increased costs required to produce NPBMP-compliant nursery stock.