bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of IR radiation on the biological value of flax seeds
Authors: Minevich Irina E. , Uschapovsky Igor V. 
Published: January 2021

Relevance. The growing demand for flax seeds as a biologically active food component is explained by the rising interest to the healthy lifestyle. In this regard, the requirements for food safety of biologically active raw materials are increasing. Heat treatment of plant materials is an effective method for the eliminating of factors that reduce nutritional and biological value food components. Thermal treatment of flax seeds with infra-red irradiation (IR) is a promising direction for the stabilizing of seeds component composition. Short-term high-temperature treatment of raw materials under the influence of IR (micronization) increases the microbiological purity of raw materials. However, there is not enough information about how the biological value parameters changing. The aim of this study was to study the effect of the micronization process on the biological value of flax seeds.Results. Total protein content of tested flax seeds did not changed after applying of IR treatment. The increase in the content of crude oil in micronized flax seeds is explained by the conversion of phospholipids into extractable lipids. A comparative analysis of the protein complex of flax seeds before and after micronization showed a change in the ratio of protein fractions: the content of the water-soluble fraction (albumin) decreased in four-times, the content of glutens, an alkali-soluble fraction, increased significantly, the content of globulins slightly increased. Around 20% of proteins passed into an insoluble residue. The adequacy of the final results of the low temperature cold-pressing and the short-term high-temperature treatment with IR radiation in the ratio of protein fractions in flax seeds was shown. Changes in the ratio of protein fractions occurring during these technological operations are similar. It was concluded that under the influence of shortterm high-temperature IR-treatment the soft denaturation of the proteins is occurred. That effect of micronization on flax seed increases the protein digestibility
Penguatan Kapasitas Tata Kelola Keuangan dan Komunikasi pada Pelaksanaan Program Badan Usaha Milik Desa di Desa Gendro Pasuruan
Authors: Kriyantono Rachmat , Laturrakhmi Yun Fitrahyati , Swastikawara Sinta , Ari Dessanti Putri Sekti 
Published: January 2021

Strengthening Financial Governance and Communication Capacity in The Implementation of Village-Owned Business Agency Programs in Gendro Village Pasuruan
This article describes community service programs to provide organizational capacity strengthening to increase the Village-Owned Enterprises (BUMDES) program's effectiveness. BUMDES demands program implementers' management capabilities as a government program to develop villages, both BUMDES administrators and village governments. This management capability is related to transparency in budget management and communication management, which ultimately becomes one of the parameters that determine the level of public trust in the management of BUMDES. The Community Service Team aims to strengthen the capacity of financial governance and communication in the management of BUMDES in Gendro Village, Pasuruan Regency. Activities were carried out through workshops and assistance to BUMDES managers. This activity was attended by all BUMDES managers and village government officials. This activity was carried out from June to September 2020. This activity found that the capacity of financial and communication governance was constrained by a lack of support from the village government, communication problems between Bumdes managers and village heads, managers had not focused optimally, and low cooperation between managers. This activity was able to provide understanding and application capabilities regarding the management of transparent financial reports and effective communication management with the village government. It is hoped that this capacity will make Bumdes independent and able to innovate in developing village potentials to become a source of business for Gendro Village.
STUDENTS'S INTENTION TO USE EMOTION-AWARE VIRTUAL LEARNING ENVIRONMENT: DOES A LECTURER'S INTERACTION MAKE A DIFFERENCE?
Authors: Nassr Rasheed Mohammad , Aldossary Alia Ahmed , Nasir Haidawati Mohamad 
Published: January 2021

Purpose: This study explored studentsâ€™ perspective of using emotion-aware Vertual Learning Environment (VLE) in Malaysiaâ€™s higher education institutions. The purpose is to investigate the relationships among dimensions of Technology Readiness Index (TRI), attitude, intention to use VLE, and lecturer interaction. The outcomes concerned the emotions involved in the educational process of Malaysiaâ€™s higher education institutions. Methodology: Quantitative data were collected via an online survey from 260 students. An empirical analysis was then conducted using structural equation modelling (Smart PLS) in two phases: (1) examining the direct effect of studentsâ€™ attitude on VLE adoption intention and (2) examining the indirect effect of constructs using lecturer interaction as a mediator. Findings: The findings revealed a significant mediating role of lecturer interaction on the relationship between attitude and intention to use VLE across the student cohort. Inhibitors, such as insecurity and discomfort, were less significant in affecting studentsâ€™ attitude towards emotion-aware VLE. The results indicate that students are motivated to use VLE when lecturers understand their emotions and react accordingly. Significance: This is one of the studies pertaining to emotions in VLE and lecturer interaction in higher education institutions. The results facilitate an understanding of the pedagogical role of lecturer interaction as a practical learning motivation. It is of particular interest to curriculum and e-learning stakeholders looking to improve studentsâ€™ interactions with the VLE systems. Apart from extending the current literature, this study has significant practical implications for education management in higher learning institutions.
Resultados perinatales según la vía del parto en pretérminos en la clínica maternidad rafael calvo
Authors: Beracaza Robledo Cristina , Salcedo Ramos Francisco , Rodríguez Yance Benjamín , Castañeda Alfonso Sergio , Olarte Parra Juan 
Published: January 2021

Introducción: el parto pretérmino (PP) actualmente constituye un problema de salud pública. El aumento de las tasas de prematuridad ha llevado al aumento en las tasas de complicaciones neonatales, inherentes a la falta de madurez fetal.Objetivo: observar los resultados perinatales logrados en nacidos pretérminos (NP) enun centro obstétrico de referencia.Materiales y métodos: estudio descriptivo-retrospectivo en el que se determinó la prevalencia de las complicaciones neonatales en NP, teniendo en cuenta la vía del parto.Realizado en la ESE Clínica Maternidad Rafael Calvo durante el período comprendidoentre el 1 de enero y el 31 de diciembre de 2014.Resultados: se incluyeron 822 historias clínicas de pacientes, 426 (51.8%) que tuvieron parto por cesárea y 396 (48.2%) por vía vaginal, la mediana de edad de los grupospor cesárea y vaginal fue de 23 y 20 años, respectivamente. Dentro de los diagnósticos de ingreso resalta de manera significativa, mayor ocurrencia en el grupo cesárea del oligohidramnios y los trastornos hipertensivos del embarazo, mientras que el trabajode PP de inicio espontáneo fue más frecuente en el grupo de parto vaginal, p <0.0001.No hubo diferencia estadísticamente significativa en la presentación de hemorragia intraventricular, trauma neonatal, enterocolitis necrotizante y muerte neonatal entre los dos grupos. Sin embargo, se presentaron diferencias en la infección neonatal, ingreso a UCI, requerimiento de ventilación mecánica y tiempo de ventilación, siendo mayor en el grupo de parto por cesárea.Conclusión: los resultados perinatales adversos más prevalentes en NP por cesárea fueron: necesidad de oxígeno suplementario, síndrome de distrés respiratorio, ingreso a UCIN, infección neonatal, sepsis temprana, taquipnea transitoria y la enfermedad de membrana hialina. En NP por vía vaginal las morbilidades más prevalentes observadas fueron: distrés respiratorio, taquipnea transitoria, sepsis e infección neonatal. Rev. cienc.biomed. 2015;6(2):282-289
Guía semiológica go
Authors: Borre Arrieta Orlando , Rodríguez Yances Benjamín , Salcedo Ramos Francisco 
Published: January 2021

Desde los inicios del Departamento de Ginecología y Obstetricia de la Universidad deCartagena-Colombia, hace más de medio siglo, se ha venido enseñando la Cátedra de Semiología, la cual ha sido desarrollada sin uniformidad en la comunicación de algunosconceptos, lo cual puede generar confusión. Muchas de esas conceptualizaciones han sidoentregadas de generación en generación, sin una fundamentación bibliográfica suficienteque homogenice la transmisión del conocimiento y la adecuada apropiación por parte delos estudiantes de pregrado.
A Novel Design of Temporomandibular Joint Prosthesis for Lateral Pterygoid Muscle Attachment: A Preliminary Study
Authors: Zou Luxiang , Zhong Yingqian , Xiong Yinze , He Dongmei , Li Xiang , Lu Chuan , Zhu Huimin 
Published: January 2021

Introduction: In temporomandibular joint (TMJ) replacement operation, due to the condylectomy, the lateral pterygoid muscle (LPM) lost attachment and had impact on the mandible kinematic function. This study aimed to design a novel TMJ replacement prosthesis for LPM attachment and to verify its feasibility by preliminary in vitro and in vivo experiments.Materials and Methods: An artificial TMJ prosthesis designed with a porous structure on the condylar neck region for LPM attachment was fabricated by a 3D printed titanium (Ti) alloy. A rat myoblast cell line (L6) was tested for adhesion and biocompatibility with porous titanium scaffolds in vitro by cell counting Kit-8 (CCK-8), scanning electron microscope (SEM), flow cytometry (FCM), real-time quantitative polymerase chain reaction (RT-qPCR), immunocytofluorescense, western blotting, etc. The porous titanium scaffolds were further embedded in the rat intervertebral muscle to analyze muscle growth and biomechanical strength in vivo. The novel artificial TMJ prosthesis was implanted to reconstruct the goat's condyle and LPM reattachment was analyzed by hard tissue section and avulsion force test.Results: L6 muscle cells showed good proliferation potential on the porous Ti scaffold under SEM scanning and FCM test. In RT-qPCR, immunocytofluorescense and western blotting tests, the L6 cell lines had good myogenic capacity when cultured on the scaffold with high expression of factors such as Myod1 and myoglobin, etc. In the in vivo experiment, muscles penetrated into the porous scaffold in both rats and goats. In rat's intervertebral muscle implantation, the avulsion force was 0.716 N/mm2 in 4 weeks after operation and was significantly increased to 0.801 N/mm2 at 8 weeks (p &lt; 0.05). In goat condylar reconstruction with the porous scaffold prosthesis, muscles attached to the prosthesis with the avulsion force of 0.436 N/mm2 at 8 weeks, but was smaller than the biological muscle-bone attachment force.Conclusion: The novel designed TMJ prosthesis can help LPM attach to its porous titanium scaffold structure area for future function.
A Novel Approach for Predicting Atrial Fibrillation Recurrence After Ablation Using Deep Convolutional Neural Networks by Assessing Left Atrial Curved M-Mode Speckle-Tracking Images
Authors: Hwang Yi-Ting , Lee Hui-Ling , Lu Cheng-Hui , Chang Po-Cheng , Wo Hung-Ta , Liu Hao-Tien , Wen Ming-Shien , Lin Fen-Chiung , Chou Chung-Chuan 
Published: January 2021

Aims: Curved M-mode images of global strain (GS) and strain rate (GSR) provide sufficiently detailed spatiotemporal information of deformation mechanics. This study investigated whether a deep convolutional neural network (CNN) could accurately classify these images in patients with atrial fibrillation (AF) who underwent radiofrequency catheter ablation (RFCA) with different outcomes.Methods and Results: We retrospectively evaluated 606 consecutive patients who underwent RFCA for drug-refractory AF. Patients were divided into AF-free (n = 443) and AF-recurrent (n = 163) groups. Transthoracic echocardiography was performed within 24 h after RFCA. Left atrial curved M-mode speckle-tracking images were acquired from randomly selected 163 patients in AF-free group and 163 patients in AF-recurrent group as the dataset for deep CNN modeling. We used the ReLu activation function and repeatedly performed CNN model for 32 times to evaluate the stability of hyperparameters. Logistic regression models with the left atrial dimension, emptying fraction, and peak systolic GS as predictor variables were used for comparisons. Images from the apical 2-chamber (2-C) and 4-chamber (4-C) views had distinct features, leading to different CNN performance between settings; of them, the “4-C GS+4-C GSR” setting provided the highest performance index values. All four predictor variables used for logistic regression modeling were significant; however, none of them, individually or in any combined form, could outperform the optimal CNN model.Conclusion: The novel approach using deep CNNs for learning features of left atrial curved M-mode speckle-tracking images seems to be optimal for classifying outcome status after AF ablation.
Host Transcriptomic Response Following Administration of Rotavirus Vaccine in Infants’ Mimics Wild Type Infection
Authors: Gómez-Carballa Alberto , Barral-Arca Ruth , Cebey-López Miriam , Currás-Tuala Maria José , Pischedda Sara , Gómez-Rial José , Habgood-Coote Dominic , Herberg Jethro A. , Kaforou Myrsini , Martinón-Torres Federico , Salas Antonio 
Published: January 2021

BackgroundRotavirus (RV) is an enteric pathogen that has devastating impact on childhood morbidity and mortality worldwide. The immunologic mechanism underlying the protection achieved after RV vaccination is not yet fully understood.MethodsWe compared the transcriptome of children affected by community-acquired RV infection and children immunized with a live attenuated RV vaccine (RotaTeq®).ResultsRV vaccination mimics the wild type infection causing similar changes in children’s transcriptome, including transcripts associated with cell cycle, diarrhea, nausea, vomiting, intussusception, and abnormal morphology of midgut. A machine learning approach allowed to detect a combination of nine-transcripts that differentiates vaccinated from convalescent-naturally infected children (AUC: 90%; 95%CI: 70–100) and distinguishes between acute-infected and healthy control children (in both cases, AUC: 100%; 95%CI: 100–100). We identified a miRNA hsa-mir-149 that seems to play a role in the host defense against viral pathogens and may have an antiviral role.DiscussionOur findings might shed further light in the understanding of RV infection, its functional link to intussusception causes, as well as guide development of antiviral treatments and safer and more effective vaccines. The nine-transcript signature may constitute a marker of vaccine protection and helps to differentiate vaccinated from naturally infected or susceptible children.
Development and Validation of a Sepsis Mortality Risk Score for Sepsis-3 Patients in Intensive Care Unit
Authors: Zhang Kai , Zhang Shufang , Cui Wei , Hong Yucai , Zhang Gensheng , Zhang Zhongheng 
Published: January 2021

Background: Many severity scores are widely used for clinical outcome prediction for critically ill patients in the intensive care unit (ICU). However, for patients identified by sepsis-3 criteria, none of these have been developed. This study aimed to develop and validate a risk stratification score for mortality prediction in sepsis-3 patients.Methods: In this retrospective cohort study, we employed the Medical Information Mart for Intensive Care III (MIMIC III) database for model development and the eICU database for external validation. We identified septic patients by sepsis-3 criteria on day 1 of ICU entry. The Least Absolute Shrinkage and Selection Operator (LASSO) technique was performed to select predictive variables. We also developed a sepsis mortality prediction model and associated risk stratification score. We then compared model discrimination and calibration with other traditional severity scores.Results: For model development, we enrolled a total of 5,443 patients fulfilling the sepsis-3 criteria. The 30-day mortality was 16.7%. With 5,658 septic patients in the validation set, there were 1,135 deaths (mortality 20.1%). The score had good discrimination in development and validation sets (area under curve: 0.789 and 0.765). In the validation set, the calibration slope was 0.862, and the Brier value was 0.140. In the development dataset, the score divided patients according to mortality risk of low (3.2%), moderate (12.4%), high (30.7%), and very high (68.1%). The corresponding mortality in the validation dataset was 2.8, 10.5, 21.1, and 51.2%. As shown by the decision curve analysis, the score always had a positive net benefit.Conclusion: We observed moderate discrimination and calibration for the score termed Sepsis Mortality Risk Score (SMRS), allowing stratification of patients according to mortality risk. However, we still require further modification and external validation.
Blood–Brain Barrier Disruption and Hemorrhagic Transformation in Acute Ischemic Stroke: Systematic Review and Meta-Analysis
Authors: Arba Francesco , Rinaldi Chiara , Caimano Danilo , Vit Federica , Busto Giorgio , Fainardi Enrico 
Published: January 2021

Introduction: Hemorrhagic transformation (HT) is a complication of reperfusion therapy for acute ischemic stroke. Blood–brain barrier (BBB) disruption is a crucial step toward HT; however, in clinical studies, there is still uncertainty about this relation. Hence, we conducted a systematic review and meta-analysis to summarize the current evidence.Methods: We performed systematic review and meta-analysis of observational studies from January 1990 to March 2020 about the relation between BBB disruption and HT in patients with acute ischemic stroke with both computed tomography (CT) and magnetic resonance (MR) assessment of BBB. The outcome of interest was HT at follow-up imaging evaluation (within 48 h from symptom onset). We pooled data from available univariate odds ratios (ORs) in random-effects models with DerSimonian–Laird weights and extracted cumulative ORs.Results: We included 30 eligible studies (14 with CT and 16 with MR), N = 2,609 patients, with 88% and 70% of patients included in CT and MR studies treated with acute stroke therapy, respectively. The majority of studies were retrospective and had high or unclear risk of bias. BBB disruption was measured with consistent methodology in CT studies, whereas in MR studies, there was more variability. All CT studies provided a BBB disruption cutoff predictive of HT. Four CT and 10 MR studies were included in the quantitative analysis. We found that BBB disruption was associated with HT with both CT (OR = 3.42; 95%CI = 1.62–7.23) and MR (OR = 9.34; 95%CI = 3.16–27.59). There was a likely publication bias particularly for MR studies.Conclusion: Our results confirm that BBB disruption is associated with HT in both CT and MR studies. Compared with MR, CT has been more uniformly applied in the literature and has resulted in more consistent results. However, more efforts are needed for harmonization of protocols and methodology for implementation of BBB disruption as a neuroradiological marker in clinical practice.
Patient Reported Outcomes Measurements Information System in Stroke Patients in Full and Shortened Format
Authors: Lens Charlotte , Demeestere Jelle , Vanhaecht Kris , Lemmens Robin 
Published: January 2021

Introduction: The modified Rankin Scale (mRS) after 90 days documents outcome in stroke patients, but focusses only on activities of daily living. Here we studied stroke outcome beyond these activities by the Dutch-Flemish version of the Patient Reported Outcomes Measurement Information System (PROMIS) questionnaire.Patients and Methods: We documented the mRS at day 90 in stroke patients who filled out a questionnaire on pain intensity and seven PROMIS domains: physical function, ability to participate in social roles, anxiety, fatigue, depression, sleep disturbance, pain interference. In a subgroup of patients this questionnaire was reduced to one overall question per PROMIS domain. We correlated these findings with the mRS.Results: We received 102 questionnaires and identified physical function as the most affected PROMIS domain. The strongest correlation with mRS was found for the health domains of physical function (ρs = 0.70, p &lt; 0.001) and ability to participate in social roles (ρs = 0.61, p &lt; 0.001). The other domains with substantial proportions of patients with worse scores compared to the general population (19–44%) correlated weakly with the mRS. We identified a strong correlation between the single question per health domain and the overall score per PROMIS domain.Discussion and Conclusion: PROMIS better reflects the overall health status of stroke patients beyond functional outcome as measured by the mRS. Simplification of the questionnaire with a single question per PROMIS domain could potentially replace the full questionnaire, but needs further validation.
Case Report: PNPLA2 Gene Complex Heterozygous Mutation Leading to Neutral Lipid Storage Disease With Myopathy
Authors: Shi Jiejing , Qu Qianqian , Liu Haiyan , Zhang Yan , Cui Wenhao , Chen Ping , Lv Haidong 
Published: January 2021

Objective: To investigate the clinical features, skeletal muscle imaging, muscle pathology, blood smear and so on of neutral lipid storage disease with myopathy (NLSDM) caused by PNPLA2 gene mutation.Methods: The clinical data, skeletal muscle imaging, pathological data, and genetic test results of a patient with NLSDM treated in our hospital were collected in detail, and the previous literature was reviewed and compared.Results: The main symptoms were muscle weakness and muscular atrophy. Pathological findings of muscle biopsy showed fat deposition in muscle fibers with border cavitation. Fatty droplets were seen in the cytoplasm of neutrophils in peripheral blood. Magnetic resonance imaging of the muscles of both lower extremities showed that muscle in the thigh vastus intermedius, lateral muscles, biceps, and the muscle abdominal area of the middle leg were filled or replaced by fat. Genetic test results suggested mutations in the PNPLA2 gene.Conclusion: NLSDM is a rare clinical myopathy with abnormal lipid metabolism. Characteristic changes can be seen in skeletal muscle imaging and pathology. The detection of PNPLA2 gene mutation is an important basis for diagnosing NLSDM. Asymmetry and progressive limb weakness are the clinical features. Muscle MRI is mainly involved in the posterior group of the lower limbs. Jordans bodies in the peripheral blood smear and a large number of coarse-grained lipid deposits with rimmed vacuoles in muscle fibers are the characteristic pathological changes.