bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fanaroff–Riley classification of radio galaxies using group-equivariant convolutional neural networks
Authors: Scaife Anna M M , Porter Fiona 
Published: February 2021

ABSTRACT
Weight sharing in convolutional neural networks (CNNs) ensures that their feature maps will be translation-equivariant. However, although conventional convolutions are equivariant to translation, they are not equivariant to other isometries of the input image data, such as rotation and reflection. For the classification of astronomical objects such as radio galaxies, which are expected statistically to be globally orientation invariant, this lack of dihedral equivariance means that a conventional CNN must learn explicitly to classify all rotated versions of a particular type of object individually. In this work we present the first application of group-equivariant convolutional neural networks to radio galaxy classification and explore their potential for reducing intra-class variability by preserving equivariance for the Euclidean group E(2), containing translations, rotations, and reflections. For the radio galaxy classification problem considered here, we find that classification performance is modestly improved by the use of both cyclic and dihedral models without additional hyper-parameter tuning, and that a D16 equivariant model provides the best test performance. We use the Monte Carlo Dropout method as a Bayesian approximation to recover epistemic uncertainty as a function of image orientation and show that E(2)-equivariant models are able to reduce variations in model confidence as a function of rotation.
GAMA/DEVILS: constraining the cosmic star formation history from improved measurements of the 0.3–2.2  μm extragalactic background light
Authors: Koushan Soheil , Driver Simon P , Bellstedt Sabine , Davies Luke J , Robotham Aaron S G , Lagos Claudia del P , Hashemizadeh Abdolhosein , Obreschkow Danail , Thorne Jessica E , Bremer Malcolm , Holwerda B W , Hopkins Andrew M , Jarvis Matt J , Siudek Malgorzata , Windhorst Rogier A 
Published: February 2021

ABSTRACT
We present a revised measurement of the optical extragalactic background light (EBL), based on the contribution of resolved galaxies to the integrated galaxy light (IGL). The cosmic optical background radiation (COB), encodes the light generated by star formation, and provides a wealth of information about the cosmic star formation history (CSFH). We combine wide and deep galaxy number counts from the Galaxy And Mass Assembly survey (GAMA) and Deep Extragalactic VIsible Legacy Survey (DEVILS), along with the Hubble Space Telescope (HST) archive and other deep survey data sets, in nine multiwavelength filters to measure the COB in the range from 0.35  μm to 2.2  μm. We derive the luminosity density in each band independently and show good agreement with recent and complementary estimates of the optical-EBL from very high-energy (VHE) experiments. Our error analysis suggests that the IGL and γ-ray measurements are now fully consistent to within $\sim 10{{\ \rm per\ cent}}$, suggesting little need for any additional source of diffuse light beyond the known galaxy population. We use our revised IGL measurements to constrain the CSFH, and place amplitude constraints on a number of recent estimates. As a consistency check, we can now demonstrate convincingly, that the CSFH, stellar mass growth, and the optical-EBL provide a fully consistent picture of galaxy evolution. We conclude that the peak of star formation rate lies in the range 0.066–0.076 M⊙ yr−1 Mpc−3 at a lookback time of 9.1 to 10.9 Gyr.
Absorption effects in the blazar’s γ-ray spectra due to luminous stars crossing the jet
Authors: Bednarek W , Sitarek J 
Published: February 2021

ABSTRACT
γ-ray emission in active galaxies is likely produced within the inner jet, or in the close vicinity of the supermassive black hole (SMBH) at sub-parsec distances. γ-rays have to pass through the surrounding massive stellar cluster in which luminous stars can accidentally appear close to the observer’s line of sight. In such a case, soft radiation of massive stars can create enough target for transient absorption of the γ-rays in multi-GeV to TeV energy range. We consider the effect of such stellar encounters on the γ-ray spectrum produced within the massive stellar cluster surrounding a central SMBH. We predict characteristic, time-dependent effects on the γ-ray spectra due to the encounter with the single luminous star and also stellar binary system. We conclude that during the encounter, the γ-ray spectrum of an active galaxy should steepen at tens of GeV and harden in the range of hundreds of GeV. As an example, we consider such effects on the spectra observed from a typical blazar, 1ES 1959+650 (in an active state) and also in the case of a radio galaxy M87 (in a low state). It is shown that observation of such transient characteristic features in the γ-ray spectra, observed from blazars and radio galaxies, lays within the sensitivity of the future Cherenkov Telescope Array.
Effect of separate initial conditions on the lyman-α forest in simulations
Authors: Fernandez M A , Bird Simeon , Upton Sanderbeck Phoebe 
Published: February 2021

ABSTRACT
Using a set of high resolution simulations, we quantify the effect of species-specific initial transfer functions on probes of the intergalactic medium (IGM) via the Lyman-α forest. We focus on redshifts 2–6, after H i reionization. We explore the effect of these initial conditions on measures of the thermal state of the low density IGM: the curvature, Doppler width cutoff, and Doppler width distribution. We also examine the matter and flux power spectrum, and potential consequences for constraints on warm dark matter models. We find that the curvature statistic is at most affected at the $\approx 2{{\ \rm per\ cent}}$ level at z = 6. The Doppler width cutoff parameters are affected by $\approx 5{{\ \rm per\ cent}}$ for the intercept, and $\approx 8{{\ \rm per\ cent}}$ for the fit slope, though this is subdominant to sample variation. The Doppler width distribution shows a $\approx 30{{\ \rm per\ cent}}$ effect at z = 3, however the distribution is not fully converged with simulation box size and resolution. The flux power spectrum is at most affected by $\approx 5{{\ \rm per\ cent}}$ at high redshift and small scales. We discuss numerical convergence with simulation parameters.
Feedback factory: multiple faint radio jets detected in a cluster at z = 2
Authors: Kalita Boris S , Daddi Emanuele , Coogan Rosemary T , Delvecchio Ivan , Gobat Raphael , Valentino Francesco , Strazzullo Veronica , Tremou Evangelia , Gómez-Guijarro Carlos , Elbaz David , Finoguenov Alexis 
Published: February 2021

ABSTRACT
We report the detection of multiple faint radio sources, that we identify as active galactic nucleus (AGN) jets, within CLJ1449+0856 at z = 2 using 3 GHz Very Large Array observations. We study the effects of radio-jet-based kinetic feedback at high redshifts, which has been found to be crucial in low-redshift clusters to explain the observed thermodynamic properties of their intracluster medium (ICM). We investigate this interaction at an epoch featuring high levels of AGN activity and a transitional phase of ICM in regards to the likelihood of residual cold gas accretion. We measure a total flux of $\rm 30.6 \pm 3.3\, \mu Jy$ from the six detected jets. Their power contribution is estimated to be $1.2 \, (\pm 0.6)\, \times 10^{44} \, \rm erg\, s^{-1}$, although this value could be up to $4.7 \, \times 10^{44} \, \rm erg\, s^{-1}$. This is a factor of ∼0.25–1.0 of the previously estimated instantaneous energy injection into the ICM of CLJ1449+0856 from AGN outflows and star formation that have already been found to be sufficient in globally offsetting the cooling flows in the cluster core. In line with the already detected abundance of star formation, this mode of feedback being distributed over multiple sites, contrary to a single central source observed at low redshifts, points to accretion of gas into the cluster centre. This also suggests a ‘steady state’ of the cluster featuring non-cool-core-like behaviour. Finally, we also examine the total infrared–radio luminosity ratio for the known sample of galaxies within the cluster core and find that dense environments do not have any serious consequence on the compliance of galaxies to the infrared–radio correlation.
Physical modelling of the circumstellar material in the early-type active binary HH Carinae
Authors: Bakış H , Köseoglu D T , Bakış V , Nitschelm C , Eker Z 
Published: February 2021

ABSTRACT
High-resolution spectra ($R\sim 48\, 000$) of the massive binary system HH Carinae have been analysed. Precise absolute parameters were derived from a simultaneous solution of the radial velocities and the light curves. The primary component is found to be an O9-type main-sequence star with a temperature of 33 500 K, while the secondary component is a B0-type giant/subgiant star with a temperature of 27 500 K. An analysis of the spectroscopic and photometric data has shown that the primary component rotates at a speed of vrot1 = 220 km s−1, which is three times faster than the synchronous rotation, while the secondary component synchronously rotates with the orbit at a speed of vrot2 = 150 km s−1. The distance to the system and the velocity of the centre of mass are determined as d = 4.6 ± 0.8 kpc and Vγ = –16 km s−1, respectively. The distance of the system is in agreement with the most probable Gaia distance of $4.9^{+0.9}_{-0.7}$ kpc and the distance in the latest data release (DR3) of 4.4 ± 0.3. Emission structures at the Hα region were modelled using the code shellspec where the derived absolute parameters of the components have been considered. Because the components are massive stars, mass loss as a result of stellar winds is expected. Produced models confirm that the components do indeed have strong stellar winds and there is mass transfer from the secondary to the primary. Stellar winds and the gas stream between the components have been modelled as a hot shell around the system, with a temperature of ∼22 000 K. Models also indicate that the interaction between the wind and the gas stream causes the formation of a high-temperature (100 000 K) impact region.
Clinical Implications of Size of Cavities in Patients With Nontuberculous Mycobacterial Pulmonary Disease: A Single-Center Cohort Study
Authors: Kang Hye-Rin , Hwang Eui Jin , Kim Sung A , Choi Sun Mi , Lee Jinwoo , Lee Chang-Hoon , Yim Jae-Joon , Kwak Nakwon 
Published: February 2021

Abstract

Background
The presence of cavities is associated with unfavorable prognosis in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD). However, little is known about the characteristics of such cavities and their impact on clinical outcomes. The aim of this study was to investigate the size of cavities and their implications on treatment outcomes and mortality in patients with NTM-PD.

Methods
We included patients diagnosed with NTM-PD at Seoul National University Hospital between January 1, 2007, and December 31, 2018. We measured the size of cavities on chest computed tomography scans performed at the time of diagnosis and used multivariable logistic regression and Cox proportional hazards regression analysis to investigate the impact of these measurements on treatment outcomes and mortality.

Results
The study cohort comprised 421 patients (noncavitary, n = 329; cavitary, n = 92) with NTM-PD. During a median follow-up period of 49 months, 118 (35.9%) of the 329 patients with noncavitary and 64 (69.6%) of the 92 patients with cavitary NTM-PD received antibiotic treatment. Cavities &gt;2 cm were associated with worse treatment outcomes (adjusted odds ratio, 0.41; 95% CI, 0.17–0.96) and higher mortality (adjusted hazard ratio, 2.52; 95% CI, 1.09–5.84), while there was no difference in treatment outcomes or mortality between patients with cavities ≤2 cm and patients with noncavitary NTM-PD.

Conclusions
Clinical outcomes are different according to the size of cavities in patients with cavitary NTM-PD; thus, the measurement of the size of cavities could help in making clinical decisions.
What do Consumers Consider Before They Choose? Identification from Asymmetric Demand Responses
Authors: Abaluck Jason , Adams-Prassl Abi 
Published: February 2021

AbstractConsideration set models generalize discrete-choice models by relaxing the assumption that consumers consider all available options. Determining which options were considered has previously required either survey data or restrictions on how attributes affect consideration or utility. We provide an alternative route. In full-consideration models, choice probabilities satisfy a symmetry property analogous to Slutsky symmetry in continuous-choice models. This symmetry breaks down in consideration set models when changes in characteristics perturb consideration. We show that consideration probabilities are constructively identified from the resulting asymmetries. We validate our approach in a lab experiment where consideration sets are known and then apply our framework to study a “smart default” policy in Medicare Part D, wherein consumers are automatically reassigned to lower-cost prescription drug plans with the option of opting out. Full-consideration models imply that such a policy will be ineffective because consumers will opt out to avoid switching costs. Allowing for inattention, we find that defaulting all consumers to lower-cost options produces negligible welfare benefits on average, but defaulting only consumers who would save at least $300 produces large benefits.
Hydration Modulates G‐Protein‐Coupled Receptor Signaling
Authors: Fried Steven D.E. , Eitel Anna R. , Weerasinghe Nipuna , Norris Carolanne E. , Vos Margaret R. , Somers Johnathan D. , Fitzwater Gabrielle I. , Pitman Michael C. , Struts Andrey V. , Perera Suchithranga M.D.C. , Brown Michael F. 
Published: February 2021

Rhodopsin is the G‐protein‐coupled receptor (GPCR) responsible for scotopic vision in the retina. Up to this point, the role of water in the activation of GPCRs has remained largely unknown. Recently, however, nanosecond molecular dynamics simulations have revealed an influx of bulk water into rhodopsin during activation [1]. Utilizing rhodopsin as a model GPCR, we tested the hypothesis that rhodopsin activation is hydration mediated using osmotic stress techniques. We subjected rhodopsin within its native lipid membranes to varying osmotic pressures induced by different‐sized polyethylene glycol polymers. UV‐Visible spectroscopy of the photoactivated rhodopsin system reveals the fraction of protein in the active metarhodopsin‐II (MII) conformation, the receptor state capable of activating the G‐protein. We discovered high‐molecular weight osmolytes uniformly favored the closed, inactive metarhodopsin‐I conformation by dehydration of the protein interior. By contrast, small osmolytes penetrated into the transducin binding cleft and stabilized the active MII conformation until a quantifiable saturation point. A universal osmotic response occurred in the limit of increasing osmolyte size and maximal polymer exclusion from rhodopsin. By measuring the thermodynamic dependence of the metarhodopsin equilibrium on osmotic pressure, we determined that rhodopsin activation is coupled to a bulk influx of 80–100 water molecules into the protein core with a substantial increase in compressibility. We propose a new model for the functional role of water in GPCR signal transduction, in which a wet‐dry cycling mechanism amplifies the activation of G‐proteins. Our results necessitate a new understanding of GPCR activation, in which the influx of water plays a critical role in establishing the active receptor conformation.Support or Funding InformationThis work was supported by the NIH (EY026041 and EY012049) and the NSF (MCB 1817862).This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
Functional Water Dynamics in Rhodopsin Using Solid‐State Deuterium NMR Spectroscopy
Authors: Weerasinghe Nipuna , Perera Suchithranga M.D.C. , Molugu Trivikram R. , Brown Michael F. 
Published: February 2021

G‐protein‐coupled receptors (GPCRs) are the largest family of cell membrane‐bound proteins that detect extracellular stimuli and transduce signals to activate intracellular functions. Drugs that target GPCRs also account for about 27% of the global market share of therapeutic drugs, with aggregated sales for 2011–2015 of ca. US $890 billion [1]. Hydration is essential for protein tertiary folding and activity, and therefore knowledge of hydration water dynamics is vital for understanding the GPCR activation mechanism [2]. We studied rhodopsin hydration as a prototype for GPCRs, where the role of water in the rhodopsin activation mechanism has been recently explored using quasi‐elastic neutron scattering (QENS) methods [3]. We developed methods for generating powdered samples, notable for exceptionally high protein content while retaining photochemical functionality. The powdered GPCR samples are suitable for biophysical experiments to study the dynamic process of rhodopsin activation [4], where the protein is hydrated using vapor phase absorption in a controlled manner. We propose that the internal protein dynamics (β‐fluctuations) are coupled to the solvent shell, while large‐scale protein domain motions (α‐fluctuations) are coupled to the bulk solvent. To test our hypothesis of functional water interactions, we studied rhodopsin hydration shell dynamics using solid‐state 2H NMR spectroscopy at various hydration levels and temperatures [5]. From the spectral features at 200 K, we identified two dynamically distinguishable protein hydration regions. The broad quadrupolar splitting at approximately 180 kHz is due to bulk water; however, the anisotropic narrow component is a result of water molecules dynamically perturbed by rhodopsin. Additional solid‐state 2H NMR relaxation investigations of molecular dynamics of the rhodopsin‐bound water shell are in progress. Our future focus is on a comparative study of water dynamics in the light activated state and the dark state of the visual photoreceptor.Support or Funding InformationThis work was supported by the NIH (EY026041 and EY012049) and the NSF (MCB 1817862).This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
Improving Surgical Informed Consent
Authors: Raper Steven E. , Clapp Justin T. , Fleisher Lee A. 
Published: February 2021

Objective:
This study reviews randomized clinical trials that have attempted to improve the process of informed consent. Consent should be guided by the ethical imperatives of autonomy, beneficence, and social justice.

Summary Background:
Informed consent is constantly evolving. Yet our review of the randomized trials done to improve the surgical informed consent process raises a number of questions: How does one define surgical informed consent? What interventions have been tried to measure and improve informed consent? Have the interventions in informed consent actually led to improvements? What efforts have been made to improve informed consent? And what steps can be taken to improve the process further?

Methods:
A literature search for randomized controlled trials (RCTs)on informed consent identified 70 trials. Demographics, interventions, assessments, and a semi-quantitative summary of the findings were tabulated. The assessments done in the RCTs, show the surrogate for patient autonomy was comprehension; for beneficence, satisfaction and mental state (anxiety or depression); and, for social justice, language, literacy, learning needs, and cost.

Results:
There were 4 basic categories of interventions: printed matter; non-interactive audiovisual tools; interactive multimedia; and a smaller group defying easy description. Improvement was documented in 46 of the 65 trials that studied comprehension. Thirteen of 33 trials showed improved satisfaction. Three of 30 studies showed an increase in anxiety. Few studies tried to assess primary language or literacy, and none looked at learning needs or cost.

Conclusions:
No single study improved all 3 principles of informed consent. Validated interventions and assessments were associated with greater impact on outcomes. All 3 ethical principles should be assessed; autonomy (as comprehension), beneficence (as satisfaction, anxiety), and social justice. Not enough consideration has been given to social justice; appropriate language translation, standardized reading levels, assessment of learning needs, and cost to the individual are all important elements worthy of future study.
Clinical Impact of Stump Closure Reinforced With Hemopatch on the Prevention of Clinically Relevant Pancreatic Fistula After Distal Pancreatectomy: A Multicenter Randomized Trial
Authors: Uranues Selman , Fingerhut Abraham , Belyaev Orlin , Zerbi Alessandro , Boggi Ugo , Hoffmann Matthias W. , Reim Daniel , Esposito Alessandro , Primavesi Florian , Kornprat Peter , Coppola Roberto , Fragulidis Georgio P. , Serradilla-Martin Mario , Alimoglu Orhan , Peri Andrea , Diaconescu Bogdan 
Published: February 2021

Introduction:
Postoperative pancreatic fistula (POPF) is the most dreaded complication after distal pancreatectomy (DP). This multicenter randomized trial evaluated the efficacy, safety, and tolerance of Hemopatch in preventing clinically relevant (grades B/C according to the ISGPS classification) POPF after DP.

Material and methods:
After stump closure, patients were randomized to affix Hemopatch to the stump or not. Statistical significance was set at 0.025. Clinical significance was defined as the number of patients needed to treat (NNT) to avoid 1 B/C POPF.

Results:
Of 631 eligible patients, 360 were randomized and 315 analyzed per protocol (155 in the standard closure group; 160 in the Hemopatch group). The rates of B/C POPF (the primary endpoint) were 23.2% and 16.3% (P = 0.120), while the number of patients with 1 or more complications (including patients with B/C POPF) was 34.8% and 24.4% (P = 0.049) in the standard and Hemopatch groups, respectively. In patients with hand-sewn stump and main duct closure, the rates were 26.2% versus 10.0% (P = 0.014) and 23.3% versus 7.7% (P = 0.015) in the standard and Hemopatch groups, respectively. The NNT in these 2 subgroups was 6 and 6.4, respectively.

Conclusion:
The results of the first randomized trial evaluating Hemopatch-reinforced pancreatic stump after DP to prevent type B/C POPF do not allow us to conclude that the risk of B/C POPF was lower. Based on the NNT, however, routine use of Hemopatch after DP may result in fewer complications (including POPF) overall, especially in cases with hand-sewn closure of the pancreatic stump or main pancreatic duct.