bluuebunny/crossref_metadata_2025_split huggingface dataset:
Steps Taken for Development of Home Stay Tourism in Nepal
Authors: Adhikari Bam Bahadur 
Published: October 2021

Home stay tourism which had formally started in 1988 in form of different variety and services, is still in operation in many countries of today's world in different forms and is being operated as an important campaign to bring economic and social transformations. Home stay is being utilized as a business sector to make investments and generate income in developed countries whereas it is emphasized as a platform for production of local goods and generating employment in developing countries. Developed countries have been making huge investments in home stay and see it as a platform for business and entertainment, whereas it is being operated in different manner in developing countries. In developed countries like America, Europe, Australia, Canada etc, home stay is taken as a tool for earning high income. Developed countries emphasize on internal facilities which add to the attraction of outer environment while identifying the tourists' nature and objective and provide similar facilities. They provide required facilities for food, accommodation, studying, playing, yoga, capacity building and providing training to draw the attention of tourists. The responsibility has come upon the shoulders of related representative organizations and tourism professionals to develop home stay business as a sustainable, good quality and target based tourism. In this context, Nepalese government should develop the concept of home stay tourism in planned manner and identify its vast possibilities. It is important to have the proper direction and helpful role from the government of Nepal in home stay tourism sector which has been developing in rural areas of Nepal, along with the proper management rules and guidelines from the government's side. This article focuses in the business related to home stay and prioritizes the promotional, managerial and developmental aspects of this tourism business in Nepal.
How We Understand Aeromobility
Authors: Zuskáčová Veronika 
Published: October 2021

Abstract
Ever since the term “aeromobility” was first used in the early 2000s as a parallel to automobility, it has developed into a multilayered concept and even an individual field of research. Yet, the meanings ascribed to the terms “aeromobility,” “aeromobilities,” or “aeromobile” vary significantly depending on the scale, context, and approach of particular studies and their authors. Using elements of discourse analysis, the article explores these meanings across a wide range of academic publications and identifies four main discourses of aeromobility in mobility studies. These are the mobility-system, the norm, the embodied practice, and the lifestyle discourse. While synthesizing the different discourses, their contributions, biases and possible future routings, the article intends to inspire more abstract thinking about aeromobility and offers several suggestions to open it up as a concept with socio-cultural implications.
New interinstitutional, multimodal presurgical evaluation protocol associated with improved seizure freedom for poorly defined cases of focal epilepsy in children
Authors: Schur Solon , Moreau Jeremy T. , Khoo Hui Ming , Koupparis Andreas , Simard Tremblay Elisabeth , Myers Kenneth A. , Osterman Bradley , Rosenblatt Bernard , Farmer Jean-Pierre , Saint-Martin Christine , Turpin Sophie , Hall Jeff , Olivier Andre , Bernasconi Andrea , Bernasconi Neda , Baillet Sylvain , Dubeau Francois , Gotman Jean , Dudley Roy W. R. 
Published: October 2021

OBJECTIVE
In an attempt to improve postsurgical seizure outcomes for poorly defined cases (PDCs) of pediatric focal epilepsy (i.e., those that are not visible or well defined on 3T MRI), the authors modified their presurgical evaluation strategy. Instead of relying on concordance between video-electroencephalography and 3T MRI and using functional imaging and intracranial recording in select cases, the authors systematically used a multimodal, 3-tiered investigation protocol that also involved new collaborations between their hospital, the Montreal Children’s Hospital, and the Montreal Neurological Institute. In this study, the authors examined how their new strategy has impacted postsurgical outcomes. They hypothesized that it would improve postsurgical seizure outcomes, with the added benefit of identifying a subset of tests contributing the most.

METHODS
Chart review was performed for children with PDCs who underwent resection following the new strategy (i.e., new protocol [NP]), and for the same number who underwent treatment previously (i.e., preprotocol [PP]); ≥ 1-year follow-up was required for inclusion. Well-defined, multifocal, and diffuse hemispheric cases were excluded. Preoperative demographics and clinical characteristics, resection volumes, and pathology, as well as seizure outcomes (Engel class Ia vs > Ia) at 1 year postsurgery and last follow-up were reviewed.

RESULTS
Twenty-two consecutive NP patients were compared with 22 PP patients. There was no difference between the two groups for resection volumes, pathology, or preoperative characteristics, except that the NP group underwent more presurgical evaluation tests (p < 0.001). At 1 year postsurgery, 20 of 22 NP patients and 10 of 22 PP patients were seizure free (OR 11.81, 95% CI 2.00–69.68; p = 0.006). Magnetoencephalography and PET/MRI were associated with improved postsurgical seizure outcomes, but both were highly correlated with the protocol group (i.e., independent test effects could not be demonstrated).

CONCLUSIONS
A new presurgical evaluation strategy for children with PDCs of focal epilepsy led to improved postsurgical seizure freedom. No individual presurgical evaluation test was independently associated with improved outcome, suggesting that it may be the combined systematic protocol and new interinstitutional collaborations that makes the difference rather than any individual test.
A survival analysis of ventricular access devices for delivery of cerliponase alfa
Authors: Craven Claudia L. , Gissen Paul , Bower Rebecca , Lee Laura , Aquilina Kristian , Thompson Dominic N. P. 
Published: October 2021

OBJECTIVE
Late infantile neuronal ceroid lipofuscinosis type 2 (CLN2) is a rare autosomal recessive disease caused by tripeptidyl peptidase 1 enzyme deficiency. At the authors’ center, the medication cerliponase alfa is administered every 2 weeks via the intracerebroventricular (ICV) route. This requires the placement of a ventricular access device (VAD) or reservoir and frequent percutaneous punctures of this device over the child’s lifetime. In this study, the authors audited the longevity and survival of these VADs and examined the causes of device failure.

METHODS
A single-center survival analysis of VAD insertions and revisions (January 2014 through June 2020) was conducted. All children received cerliponase alfa infusions through a VAD. Patient characteristics and complications were determined from a prospectively maintained surgical database and patient records. For the VAD survival analysis, the defined endpoint was when the device was removed or changed. Reservoir survival was assessed using Kaplan-Meier curves and the log-rank (Cox-Mantel) test.

RESULTS
A total of 17 patients had VADs inserted for drug delivery; median (range) age at first surgery was 4 years 4 months (1 year 8 months to 15 years). Twenty-six VAD operations (17 primary insertions and 9 revisions) were required among these 17 patients. Twelve VAD operations had an associated complication, including CSF infection (n = 6) with Propionibacterium and Staphylococcus species being the most prevalent organisms, significant surgical site swelling preventing infusion (n = 3), leakage/wound breakdown (n = 2), and catheter obstruction (n = 1). There were no complications or deaths associated with VAD insertion. The median (interquartile range) number of punctures was 12.0 (7.5–82.0) for unrevised VADs (n = 17) versus 29.0 (6–87.5) for revised VADs (n = 9) (p = 0.70). The median survival was 301 days for revisional reservoirs (n = 9) versus 2317 days for primary inserted reservoirs (n = 17) (p = 0.019).

CONCLUSIONS
In the context of the current interest in intrathecal drug delivery for rare metabolic disorders, the need for VADs is likely to increase. Auditing the medium- to long-term outcomes associated with these devices will hopefully result in their wider application and may have potential implications on the development of new VAD technologies. These results could also be used to counsel parents prior to commencement of therapy and VAD implantation.
Dukungan tenaga kesehatan dalam keberhasilan ASI eksklusif: A scoping review
Authors: Fitriani Dyah Ayu , Astuti Adari Wuri , Utami Fitria Siswi 
Published: October 2021

Latar belakang: Dua tahun pertama kehidupan manusia merupakan masa emas untuk membentuk fondasi pertumbuhan, perkembangan, dan kesehatan dalam jangka panjang, sehingga sangat penting untuk memastikan bahwa anak usia 0-2 tahun mendapatkan nutrisi yang optimal. Upaya yang lebih mudah dan lebih murah untuk mencapainya adalah dengan memberdayakan ibu dalam pemberian ASI Eksklusif dan terus memberikan ASI hingga 2 tahun, serta makanan pendamping yang berkualitas. Tujuan penelitian: Mereview evidence terkait dukungan tenaga kesehatan pada ibu dalam keberhasilan ASI Eksklusif. Metode: Scoping review ini menggunakan framework dari Arksey dan O’Malley. Hasil: Berdasarkan 8 artikel terseleksi, diperoleh 3 artikel dengan grade A dan 5 artikel dengan grade B, 1 artikel dari negara berkembang dan 7 artikel dari negara maju. Tiga tema muncul sebagai hasil dari scoping review yaitu jenis dukungan tenaga kesehatan, Respon ibu terhadap dukungan tenaga kesehatan, dan manfaat dukungan tenaga kesehatan dalam keberhasilan ASI Eksklusif. Simpulan: Dari 8 artikel yang ditelaah ditemukan bahwa dukungan tenaga kesehatan adalah salah satu faktor yang terkait dengan pemberian ASI Eksklusif pada ibu yang menyusui. Secara khusus, ibu yang menerima dukungan tenaga kesehatan yang memadai memiliki manfaat dalam meningkatkan kepercayaan diri dan kepuasan ibu serta dapat menambah wawasan dan pengetahuan ibu dalam ASI Eksklusif.
PEMANFAATAN LAHAN PEKARANGAN MELALUI SISTEM VERTIKULTUR BUDIDAYA SAYURAN KELOMPOK TANI SINAR MANUMUTI DESA UPFAON
Authors: Tobing Wilda Lumban 
Published: October 2021

Tujuan dari pengabdian adalah menjadikan vertikultur sebagai alternatif keterbatasan lahan yang dimiliki oleh masyarakat dan persediaan air yang sedikit dalam budidaya sayuran. Kegiatan pengabdian dilakukan di lahan pekarangan rumah anggota kelompok tani Sinar Manumuti Desa Upfaon, Biboki Selatan, Kabupaten Timor Tengah Utara. Kegiatan ini berlangsung selama 2 (dua) bulan (Oktober-Desember 2020). Metode yang digunakan pada pengabdian ini adalah penyuluhan dan pelatihan oleh tim pengabdian sampai kelompok tani terampil dan mandiri yang terdiri dari beberapa kegiatan antara lain : 1) sosialisasi dan pelatihan pembuatan vertikultur; 2) sosialisasi dan pelatihan penggunaan media tanam; 3) sosialisasi dan pelatihan penyemaian benih; 4) sosialisasi dan pelatihan penanaman pada vertikultur; dan 5) sosialisasi dan pelatihan perawatan tanaman. Berdasarkan hasil kegiatan pengabdian di kelompok tani Sinar Manumuti di Desa Upfaon dapat disumpukan bahwa memanfaatkan lahan pekarangan melalui sistem tanam vertikultur pada budidaya sayuran memberikan solusi bagi lahan dan ketersediaan air yang terbatas, pengabdian telah memberi pengetahuan baru kepada masyarakat mengenai vertikultur dengan banyak kelebihannya, dan anggota Kelompok Tani Sinar Manumuti dapat menghemat pengeluaran belanja kebutuhan pangan keluarga tanpa harus membeli.
Upaya Pencegahan Covid19 dalam Perspektif Islam
Authors: Sukri Saipul Al , Fauzi Ahmad , Rustam Afrinaldy , Ghozali Achmad , Rusdi Rusdi , Zulfahmi Zulfahmi 
Published: October 2021

ABSTRAK Pola hidup bersih dan menjaga protokol kesehatan 3M harus tetap berjalan meskipun pelaksanaan vaksinasi sudah dilakukan. Langkah ini bertujuan agar kasus baru dan penyebaran Covid19 bisa di hentikan. Dalam upaya itu, dosen dilingkungan UIN Sultan Syarif Kasim Riau melaksanakan Kegiatan pengabdian kepada masyarakat yang dimaksudkan memberikan perspektif lain dalam usaha pencegahan dari penularan virus. Salah satunya adalah dengan menjaga kebersihan diri. Kegiatan pengabdian dilaksanakan di desa Tlk.Latak Kab. Bengkalis. kegiatan ini dilaksanakan di aula kantor desa dan diikuti oleh perangkat desa, tokoh masyarakat dan warga. Di akhir sesi, tim pengabdi memberikan cindera mata serta alat prokes berupa masker dan hand sanitizer pada perangkat desa. Kata Kunci: Kebersihan dalam Islam, penyuluhan kesehatan, Covid-19 ABSTRACT A clean lifestyle and maintaining 3M health protocols must continue even though the vaccination has been carried out. This step is intended to stop new cases and the spread of Covid-19. In that effort, lecturers within the UIN Sultan Syarif Kasim Riau carried out community service activities that were intended to provide another perspective in efforts to prevent virus transmission. One of them is to maintain personal hygiene. Service activities are carried out in the village of Tlk. Latak Kab. Bengkalis. This activity was carried out in the village office hall and was attended by village officials, community leaders, and residents. At the end of the session, the service team provided souvenirs and health care tools in the form of masks and hand sanitizers to village officials. Keywords: Cleanliness in Islam, health education, Covid-19
Meningkatkan Kesadaran Masyarakat Ciwaringin Tanah Sewa Tentang Pentingnya Protokol Kesehatan Di Masa Pandemi Covid-19
Authors: Nasution Ade Saputra , Oktalaksana Khrisna Noor , Amalia Nicki , Azizah Nita Ratu , Rahmah Syifaur , Sari Wisma 
Published: October 2021

ABSTRAK Jumlah insidensi meninggal akibat covid-19 terus meningkat di dunia dan negara berkembang seperti Indonesia. Terhitung bulan Januari-Februari 2021 terdapat 82 kasus terkonfirmasi positif COVID-19 di Kelurahan Cibogor wilayah kerja Puskesmas Bogor Tengah. Sebanyak 16 kasus dari 82 kasus terdapat di wilayah RW 01 Ciwaringin Tanah Sewa Kelurahan Cibogor. Maka penerapan protokol kesehatan menjadi prioritas utama dalam menurunkan maupun menekan penyebaran covid-19. Tujuan serangkaian kegiatan pengabdian ini, diharapkan dapat meningkatkan kesadaran, pengetahuan, kemampuan, pemahaman dan penerapan protokol kesehatan dalam kehidupan pada masa pandemi dan dapat mencegah penyebaran covid-19 di RW 01 Ciwaringin Tanah Sewa. Adapun serangkaian kegiatan yang dilakukan berupa penyuluhan protokol kesehatan secara door to door, lomba CTPS dan lomba menghias masker, dimana kegiatan ini menggunakan media poster dan peralatan lomba. Setelah dilakukan serangkian kegiatan terdapat peningkatan kesadaran, pengetahuan, kemampuan dan pemahaman masyarakat tentang menjalankan hidup di masa pandemi dengan protokol kesehatan. Kata Kunci : Protokol kesehatan, penyuluhan, CTPS, masker ABSTRACTThe number of deaths due to covid-19 continues to increase in the world and developing countries such as Indonesia. As of January-February 2021, there were 82 confirmed positive cases of COVID-19 in Cibogor Village, the working area of the Central Bogor Community Health Center. As many as 16 of the 82 cases were in the RW 01 Ciwaringin Tanah Sewa area, Cibogor Village. So the implementation of health protocols is a top priority in reducing and suppressing the spread of covid-19. The purpose of this series of service activities is expected to increase awareness, knowledge, ability, understanding, and application of health protocols in life during the pandemic and can prevent the spread of covid-19 in RW 01 Ciwaringin Tanah Sewa. There were a series of activities carried out in the form of house-to-house health protocol counseling, hand washing competitions with soap and masks decorating competitions, where these activities used posters and competition equipment. After a series of activities were carried out, there was an increase in the awareness, knowledge, abilities, and understanding of the community about living in a pandemic period with health protocols.Keywords: Health protocol, counseling, washing hands with soap, masks
Pemberian Suplemen Jahe Merah Dan Senam Kaki Diabetik Bagi Jamaah Masjid Alam Semesta (MAS) Sempaja Samarinda
Authors: Sukmana Mayusef , Widiastuti Ida Ayu Kade Sri , Sawitri Endang , Hasanah Nurul , Aminuddin Muhammad , Samsugito Iwan , Rahayu Anik Puji , Kurniawan Azi Surya , Leksono Yoga Bowo , Yanwar Syaiful 
Published: October 2021

ABSTRAK Pelaksanaan kegiatan ibadah di masjid memiliki risiko terjadinya penularan covid-19. Upaya yang dilakukan mencegah penularan selain menerapkan protokol kesehatan adalah dengan meningkatkan imunitas dan meningkatkan kebugaran jamaah masjid melalui pemberian jahe dan senam kaki diabetic. Pengabdian masyarakat bertujuan jamaah masjid Alam Semesta Sempaja Samarinda mampu mempraktikan senam kaki diabetik dan meminum jahe dalam rangka meningkatkan kebugaran dan imunitas tubuh. Metode yang digunakan adalah mendemontrasikan senam kaki diabetic, senam bersama, edukasi manfaat jahe, meminum jahe bersama dan membagikan jahe untuk 7 hari. Kegiatan menerapkan protokol kesehatan melalui pengukuran suhu dan membagikan masker, Kegiatan dikuti oleh seluruh jamaah Masjid Alam Semesta Sempaja berjumlah 80 orang. Para jamaah mampu melakukan senam kaki diabetic dan rutin meminum jahe. Kata kunci : Senam Kaki Diabetic, Jahe ABSTRACT The implementation of worship activities in mosques has a risk of covid-19 transmission. Efforts made to prevent transmission in addition to implementing health protocols are to increase immunity and improve the fitness of mosque’s congregations through the provision of ginger water and diabetic foot exercises. Community service aims at the congregation of the Alam Semesta Sempaja Samarinda mosque to be able to practice diabetic foot exercises and drink ginger water in order to improve fitness and immunity. The method used was to demonstrate diabetic foot exercise, doing the exercise together, educate the benefits of ginger water, drink ginger water together and distribute ginger water for 7 days. The activity of implementing health protocols by measuring temperature and distributing masks, this activity was attended by 80 congregations of the Alam Semesta Sempaja Mosque. The congregation is able to do diabetic foot exercises and drink ginger water regularly. Keyword: Diabetic Foot Gymnastics, Ginger Water
A CRISPR-Cas12b–Based Platform for Ultrasensitive, Rapid, and Highly Specific Detection of Hepatitis B Virus Genotypes B and C in Clinical Application
Authors: Chen Xu , Tan Yan , Wang Shuoshi , Wu Xueli , Liu Rui , Yang Xinggui , Wang Yi , Tai Jun , Li Shijun 
Published: October 2021

Hepatitis B virus (HBV) is one of the most dangerous and prevalent agents that causes acute and chronic liver diseases in humans. Genotyping plays an important role in determining clinical outcomes and response to antiviral treatment in HBV–infected patients. Here, we first devised a CRISPR–based testing platform, termed “CRISPR-HBV,” for ultrasensitive, highly specific, and rapid detection of two major HBV genotypes (HBV-B and HBV-C) in clinical application. The CRISPR-HBV employed multiple cross displacement amplification (MCDA) for rapid preamplification and then Cas12b–based detection for decoding the targets. Finally, the detection result was read out with real-time fluorescence and a lateral flow biosensor. The sensitivity of CRISPR-HBV was 10 copies per test. The specificity was one hundred percent, and no cross reactions were observed in other HBV genotypes and pathogens. The whole detection process, including DNA template extraction (15 min), preamplification reaction of MCDA (30 min at 65°C), CRISPR-Cas12b–based detection (5 min at 37°C), and results readout (∼2 min), could be completed within 1 h. The feasibility of the CRISPR-HBV assay for genotyping HBV-B and -C as successfully validated with clinical samples. Hence, the CRISPR-HBV assay has remarkable potential to develop a point-of-care testing for identifying and distinguishing HBV genotypes B and C in clinical settings, especially in resource-scarcity countries.
Social Jetlag and Cardiometabolic Risk in Preadolescent Children
Authors: Castro Nicholas , Diana Jake , Blackwell Jade , Faulkner James , Lark Sally , Skidmore Paula , Hamlin Michael , Signal Leigh , Williams Michelle A. , Stoner Lee 
Published: October 2021

Objective: Childhood cardiometabolic disease risk (CMD) has been associated with short sleep duration. Its relationship with other aspects of sleep should also be considered, including social jetlag (SJL) which represents the difference between a person's social rhythms and circadian clock. This study investigated whether childhood CMD risk is associated with sleep duration, sleep disturbances, and SJL.Study Design: The observational study included 332 children aged 8–10 years (48.5% female). The three independent variables were sleep duration, sleep disturbances, and SJL. SJL was calculated as the variation in hours between the midpoint of sleep during free (weekend) days and work/school days. Eleven cardiometabolic biomarkers were measured, including central blood pressure, lipids, glycated hemoglobin, arterial wave reflection, and glucose. Underlying CMD risk factors were identified using factor analysis.Results: Four underlying CMD risk factors were identified using factor analysis: blood pressure, cholesterol, vascular health, and carbohydrate metabolism. Neither sleep disturbances nor sleep duration were significantly associated with any of the four CMD factors following adjustments to potential confounders. However, SJL was significantly linked to vascular health (p = 0.027) and cholesterol (p = 0.025).Conclusion: These findings suggest that SJL may be a significant and measurable public health target for offsetting negative CMD trajectories in children. Further studies are required to determine biological plausibility.