bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recurrent and concurrent patterns of regional BOLD dynamics and functional connectivity dynamics in cognitive decline
Authors: Liang Lingyan , Yuan Yueming , Wei Yichen , Yu Bihan , Mai Wei , Duan Gaoxiong , Nong Xiucheng , Li Chong , Su Jiahui , Zhao Lihua , Zhang Zhiguo , Deng Demao 
Published: January 2021

Abstract
Background
The brain’s dynamic spontaneous neural activity and dynamic functional connectivity (dFC) are both important in supporting cognition, but how these two types of brain dynamics evolve and co-evolve in subjective cognitive decline (SCD) and mild cognitive impairment (MCI) remain unclear. The aim of the present study was to investigate recurrent and concurrent patterns of two types of dynamic brain states correlated with cognitive decline.

Methods
The present study analyzed resting-state functional magnetic resonance imaging data from 62 SCD patients, 75 MCI patients, and 70 healthy controls (HCs). We used the sliding-window and clustering method to identify two types of recurrent brain states from both dFC and dynamic regional spontaneous activity, as measured by dynamic fractional amplitude of low-frequency fluctuations (dfALFF). Then, the occurrence frequency of a dFC or dfALFF state and the co-occurrence frequency of a pair of dFC and dfALFF states among all time points are extracted for each participant to describe their dynamics brain patterns.

Results
We identified a few recurrent states of dfALFF and dFC and further ascertained the co-occurrent patterns of these two types of dynamic brain states (i.e., dfALFF and dFC states). Importantly, the occurrence frequency of a default-mode network (DMN)-dominated dFC state was significantly different between HCs and SCD patients, and the co-occurrence frequencies of a DMN-dominated dFC state and a DMN-dominated dfALFF state were also significantly different between SCD and MCI patients. These two dynamic features were both significantly positively correlated with Mini-Mental State Examination scores.

Conclusion
Our findings revealed novel fMRI-based neural signatures of cognitive decline from recurrent and concurrent patterns of dfALFF and dFC, providing strong evidence supporting SCD as the transition phase between normal aging and MCI. This finding holds potential to differentiate SCD patients from HCs via both dFC and dfALFF as objective neuroimaging biomarkers, which may aid in the early diagnosis and intervention of Alzheimer’s disease.
Can adaptive clinical trials help to solve the productivity crisis of the pharmaceutical industry? - a scenario analysis
Authors: Mahlich Jörg , Bartol Arne , Dheban Srirangan 
Published: January 2021

Abstract
Aim
The productivity of pharmaceutical research and development (R&D) investments is declining due to high failure rates in clinical research. Recently, the US Food and Drug Administration (FDA) acknowledged that adaptive designs can make drug development more efficient and less costly. Our objective is to simulate cost-saving effects and estimate the impact on global R&D expenditures as well as possible outcomes measured in life-years gained.

Methods
Based on published drug-development cost data we calculate potential cost savings derived from variations in clinical success rates that result from employing adaptive trial designs. In a subsequent step we estimate how those cost changes affect global R&D expenditures and outcomes.

Results
Our calculations indicate that an adaptive trial design with the potential to increase success rates of clinical trials by 4 percentage points could lower development costs for a new drug from 2.6 to 2.2bn USD. On a global scale, this cost reduction would free up an additional 4.2bn USD for investment into pharmaceutical R&D to bring about drug innovations that in turn would be capable of generating up to 3.5 million life-years.

Conclusion
New clinical trial designs are crucial to improving productivity within the pharmaceutical industry and to fostering a sustainable health-care system.
Early detection of sepsis using artificial intelligence: a scoping review protocol
Authors: Pepic Ivana , Feldt Robert , Ljungström Lars , Torkar Richard , Dalevi Daniel , Maurin Söderholm Hanna , Andersson Lars-Magnus , Axelson-Fisk Marina , Bohm Katarina , Sjöqvist Bengt Arne , Candefjord Stefan 
Published: January 2021

Abstract
Background
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. To decrease the high case fatality rates and morbidity for sepsis and septic shock, there is a need to increase the accuracy of early detection of suspected sepsis in prehospital and emergency department settings. This may be achieved by developing risk prediction decision support systems based on artificial intelligence.

Methods
The overall aim of this scoping review is to summarize the literature on existing methods for early detection of sepsis using artificial intelligence. The review will be performed using the framework formulated by Arksey and O’Malley and further developed by Levac and colleagues. To identify primary studies and reviews that are suitable to answer our research questions, a comprehensive literature collection will be compiled by searching several sources. Constrictions regarding time and language will have to be implemented. Therefore, only studies published between 1 January 1990 and 31 December 2020 will be taken into consideration, and foreign language publications will not be considered, i.e., only papers with full text in English will be included. Databases/web search engines that will be used are PubMed, Web of Science Platform, Scopus, IEEE Xplore, Google Scholar, Cochrane Library, and ACM Digital Library. Furthermore, clinical studies that have completed patient recruitment and reported results found in the database ClinicalTrials.gov will be considered. The term artificial intelligence is viewed broadly, and a wide range of machine learning and mathematical models suitable as base for decision support will be evaluated. Two members of the team will test the framework on a sample of included studies to ensure that the coding framework is suitable and can be consistently applied. Analysis of collected data will provide a descriptive summary and thematic analysis. The reported results will convey knowledge about the state of current research and innovation for using artificial intelligence to detect sepsis in early phases of the medical care chain.

Ethics and dissemination
The methodology used here is based on the use of publicly available information and does not need ethical approval. It aims at aiding further research towards digital solutions for disease detection and health innovation. Results will be extracted into a review report for submission to a peer-reviewed scientific journal. Results will be shared with relevant local and national authorities and disseminated in additional appropriate formats such as conferences, lectures, and press releases.
Factors that influence adherence to surgical antimicrobial prophylaxis (SAP) guidelines: a systematic review
Authors: Hassan Sarah , Chan Vincent , Stevens Julie , Stupans Ieva 
Published: January 2021

Abstract
Background
Despite the extensive research that has been conducted to date, practice often differs from established guidelines and will vary between individuals and organisations. It has been noted that the global uptake of local and international surgical antimicrobial prophylaxis (SAP) guidelines is poor with limited research investigating factors that affect guideline adherence. The purpose of this systematic review was to determine the reported barriers and enablers to the adherence of SAP guidelines.

Methods
A search of the literature was performed using four electronic databases (CINAHL, EMBASE, PubMed and SCOPUS) for articles published in the English language from January 1998 to December 2018. Articles were included if they were solely related to SAP and discussed the barriers or enablers to SAP guideline adherence. Articles that assessed the adherence to a range of infection control measures or discussed adherence to antibiotic treatment guidelines rather than SAP guidelines were excluded from this review. Barriers and enablers were mapped to the Theoretical Domains Framework (TDF). The Mixed Methods Appraisal Tool was used to assess the quality of included studies.

Results
A total of 1489 papers were originally retrieved, with 48 papers meeting the eligibility criteria. Barriers and enablers were mapped to 11 out of 14 TDF domains: knowledge, skills, social/professional role and identity, beliefs about capabilities, beliefs about consequences, reinforcement, memory, attention and decision processes, environmental context and resources, social influences, emotion and behavioural regulation. Barriers were further categorised into personal or organisational barriers, while enablers were arranged under commonly trialled interventions.

Conclusions
There are numerous factors that can determine the uptake of SAP guidelines. An identification and understanding of these factors at a local level is required to develop tailored interventions to enhance guideline adherence. Interventions, when used in combination, can be considered as a means of improving guideline use.
Oxidative stability of chia seed oil and flax seed oil and impact of rosemary (Rosmarinus officinalis L.) and garlic (Allium cepa L.) extracts on the prevention of lipid oxidation
Authors: Jung Hyojik , Kim Inhwan , Jung Sunghyeon , Lee Jihyun 
Published: January 2021

AbstractChia seed and flax seed oils are rich in polyunsaturated fatty acids, but are susceptible to oxidative deterioration. The aim of this study was to determine the oxidative stability of chia seed and flax seed oils and enhance the stability using rosemary or garlic extracts. During accelerated storage at 65 °C for 14 days, the antioxidant abilities of rosemary or garlic extracts were evaluated and compared with those of butylated hydroxy toluene, ascorbyl palmitate, and α-tocopherol using peroxide value, conjugated dienoic acids, free fatty acid, thiobarbituric acid value analysis. The profile of volatiles, fatty acid composition, and the tocopherol contents in the treated and/or untreated oils were also determined. Active ingredients of rosemary and garlic extracts were also determined. Rosemary extract was found to provide higher oxidative stability than garlic extract after 14 days in most assays (e.g., the CDA values of 4.8% for rosemary extract and 5.2% for garlic extract in chia seed oil). The contents of γ-tocopherol, linoleic acid, and α-linolenic acid were well retained in the functional oils treated with the two extracts. After accelerated storage, the content of the major odor-active volatiles varied based on the type of oil. Our findings show the potential of natural aromatic plant extracts with respect to improving the oxidative stability of functional oils.
Impact of alternative regional trade arrangements on the Ethiopian economy
Authors: Amogne Habtamu Shiferaw , Hagiwara Taiji 
Published: January 2021

AbstractThe Common Market for Eastern and Southern Africa (COMESA) is a Free Trade Area (FTA) regional trade agreement in Africa. Currently, Ethiopia is negotiating to join COMESA FTA. This study assesses the impact of three regional trade arrangements, COMESA FTA, customs unions, and the European Partnership Agreement (EPA) on the economy of Ethiopia. The analysis is based on a static Global Trade Analysis Project (GTAP) model, version 9 database. Unlike previous studies, the customs union scenarios are designed at the detailed Harmonized System (HS) level. COMESA FTA (scenario 1) with standard GTAP model results in a welfare loss for Ethiopia due to negative terms of trade and investment-saving effect, but with unemployment closure (scenario 2); Ethiopia enjoys a welfare gain mainly due to endowment effect. In scenario 3 (COMESA customs union) and scenario 4 (European Partnership Agreement), Ethiopia loses due to negative terms of trade and investment-saving effect. There is a large increase in demand for unskilled labor force in Ethiopia by around US$23 million, US$112 million, and US$43 million for scenario 2, 3, and 4 respectively. Moreover, there is a positive output effect for oilseeds, leather, and basic metals across all scenarios. The world, as a whole, enjoys welfare gains with COMESA FTA (scenario 1 and 2). However, with scenario 3 and 4, there is an overall welfare loss. There is no strong reason for Ethiopia to move to the customs union, and the EPA in the short run. Therefore, a transition period is necessary, but it is recommended for Ethiopia to join COMESA FTA.
Off-label intravenous thrombolysis for early recurrent brain embolism associated with aortic arch thrombus
Authors: Koutroulou Ioanna , Tsivgoulis Georgios , Rafailidis Vasileios , Psoma Elissavet , Kouskouras Konstantinos , Fotiadis Panagiotis , Grigoriadis Nikolaos , Karapanayiotides Theodoros 
Published: January 2021

AbstractSafety data of intravenous thrombolysis (IVT) in presence of aortic arch thrombus is scant. Furthermore, IVT is debatable in patients with prior recent stroke. We present a 51-year-old woman with recurrent major infarction 5 days after a minor left MCA territory stroke. She had a floating aortic arch thrombus and she was treated safely and effectively with off-label IVT. Patients with small infarct volumes and mild/no residual neurological deficits after an initial stroke might be considered for IVT in case of early recurrence. IVT may be reasonable in a context of acute severely disabling stroke associated with aortic arch thrombus.
Contributions of White and Brown Adipose Tissues to the Circadian Regulation of Energy Metabolism
Authors: Heyde Isabel , Begemann Kimberly , Oster Henrik 
Published: January 2021

Abstract
The term energy metabolism comprises the entirety of chemical processes associated with uptake, conversion, storage, and breakdown of nutrients. All these must be tightly regulated in time and space to ensure metabolic homeostasis in an environment characterized by cycles such as the succession of day and night. Most organisms evolved endogenous circadian clocks to achieve this goal. In mammals, a ubiquitous network of cellular clocks is coordinated by a pacemaker residing in the hypothalamic suprachiasmatic nucleus. Adipocytes harbor their own circadian clocks, and large aspects of adipose physiology are regulated in a circadian manner through transcriptional regulation of clock-controlled genes. White adipose tissue (WAT) stores energy in the form of triglycerides at times of high energy levels that then serve as fuel in times of need. It also functions as an endocrine organ, releasing factors in a circadian manner to regulate food intake and energy turnover in other tissues. Brown adipose tissue (BAT) produces heat through nonshivering thermogenesis, a process also controlled by the circadian clock. We here review how WAT and BAT contribute to the circadian regulation of energy metabolism. We describe how adipose rhythms are regulated by the interplay of systemic signals and local clocks and summarize how adipose-originating circadian factors feed-back on metabolic homeostasis. The role of adipose tissue in the circadian control of metabolism becomes increasingly clear as circadian disruption leads to alterations in adipose tissue regulation, promoting obesity and its sequelae. Stabilizing adipose tissue rhythms, in turn, may help to combat disrupted energy homeostasis and obesity.
KIF15 Supports Spermatogenesis Via Its Effects on Sertoli Cell Microtubule, Actin, Vimentin, and Septin Cytoskeletons
Authors: Wu Siwen , Lv Lixiu , Li Linxi , Wang Lingling , Mao Baiping , Li Jun , Shen Xian , Ge Renshan , Wong Chris K C , Sun Fei , Cheng C Yan 
Published: January 2021

AbstractThroughout spermatogenesis, cellular cargoes including haploid spermatids are required to be transported across the seminiferous epithelium, either toward the microtubule (MT) plus (+) end near the basement membrane at stage V, or to the MT minus (−) end near the tubule lumen at stages VI to VIII of the epithelial cycle. Furthermore, preleptotene spermatocytes, differentiated from type B spermatogonia, are transported across the Sertoli cell blood-testis barrier (BTB) to enter the adluminal compartment. Few studies, however, have been conducted to explore the function of MT-dependent motor proteins to support spermatid transport during spermiogenesis. Herein, we examined the role of MT-dependent and microtubule plus (+) end–directed motor protein kinesin 15 (KIF15) in the testis. KIF15 displayed a stage-specific expression across the seminiferous epithelium, associated with MTs, and appeared as aggregates on the MT tracks that aligned perpendicular to the basement membrane and laid across the entire epithelium. KIF15 also tightly associated with apical ectoplasmic specialization, displaying strict stage-specific distribution, apparently to support spermatid transport across the epithelium. We used a loss-of-function approach by RNAi to examine the role of KIF15 in Sertoli cell epithelium in vitro to examine its role in cytoskeletal-dependent Sertoli cell function. It was noted that KIF15 knockdown by RNAi that reduced KIF15 expression by ~70% in Sertoli cells with an established functional tight junction barrier impeded the barrier function. This effect was mediated through remarkable changes in the cytoskeletal organization of MTs, but also actin-, vimentin-, and septin-based cytoskeletons, illustrating that KIF15 exerts its regulatory effects well beyond microtubules.
Effect of balance training with Biodex Balance System to improve balance in patients with diabetic neuropathy: A quasi experimental study
Authors: Daud Syeda Afsheen Hasnain , Rahman Mujeeb Ur , Arsh Aatik , Junaid Muhammad 
Published: January 2021

Objective: To determine the effect of balance training with Biodex Balance System in improving balance function in patients with diabetic neuropathy.
Methods: A quasi experimental study was conducted at physiotherapy department of Rehman Medical Institute Peshawar from January to June 2018. Thirty-eight Diabetes Mellitus Type-II patients with diagnosis of diabetic neuropathy participated in the study. Those patients were included who were able to stand independently and who scored moderate or severe neuropathy on Toronto Scale. Participants received 12 sessions (two sessions per week) of balance training on Biodex stability system in six weeks. Berg Balance Scale and Time Up and Go test were used to collect pre and post treatment data. Paired sample T-test was used to compare pre and post treatment data because data was normally distributed.
Results: The mean age of the participants was 63.08 ± 3.3 years. Pretreatment Berg Balance Scale score was 42.68 ± 3.7 which improved to 48.89 ±3.7 after the treatment (P<0.001). Similarly, pretreatment Time Up and Go test score was 17.47 ± 2.0 while post treatment score was 13.57 ±1.5 (P<0.001).
Conclusion: Balance training with Biodex Balance System can significantly improve balance function in Diabetes Mellitus Type-II patients with diabetic neuropathy.
doi: https://doi.org/10.12669/pjms.37.2.2336
How to cite this:Daud SAH, Mujeeb-Ur-Rahman, Arsh A, Junaid M. Effect of balance training with Biodex Balance System to improve balance in patients with diabetic neuropathy: A quasi experimental study. Pak J Med Sci. 2021;37(2):389-392. doi: https://doi.org/10.12669/pjms.37.2.2336
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Seguridad Ciudadana y Gasto Público: reflexiones sobre el caso colombiano
Authors: Vargas Velásquez Alejo , García Pinzón Viviana 
Published: January 2021

RESUMEN: El objetivo de este artículo es responder las dos siguientes preguntas: ¿existe una política clara de seguridad ciudadana en Colombia? y ¿cómo caracterizar el gasto del Estado colombiano en seguridad ciudadana? Para responder estas preguntas, en la primera parte del texto se presenta el marco institucional y legal de la seguridad, con énfasis en lo pertinente a la seguridad ciudadana. En la segunda parte, se analiza el papel de la seguridad ciudadana en el marco de la Política de Defensa y Seguridad Democrática, la cual es la directriz de la política de seguridad en Colombia. En tercer lugar se examina la composición del gasto en defensa y seguridad en Colombia y la del sector social y de justicia, con la intención de analizar el peso de las medidas de control y prevención en la política pública de seguridad. Finalmente, se presentan algunas conclusiones y sugerencias suscitadas a partir del análisis precedente. ABSTRACT: The objective of this article is to answer the following two questions: is there a clear citizen security policy in Colombia? And, what are the characteristics of the Colombian public expenditure on citizen security? To answer these questions, in the first part the legal and institutional framework of the security policy is presented with an emphasis on those parts which are pertinent to citizen security. In the second part is analyzed the role of the citizen security within the Defense and Democratic Security Policy, which is a guideline of the security policy in Colombia.In third place, the composition of the security and defense budget, as well as those of the justice and social sectors, are considered in order to analyze the role of the control and preventative measures within the security policy. Finally, some conclusions and suggestions based on the previous analysis are presented.
Los costos económicos de la violencia en El Salvador
Authors: Acevedo Carlos 
Published: January 2021

RESUMEN: Este trabajo efectúa un ejercicio de cuantificación de los costos económicos asociados a las diversas manifestaciones y consecuencias de la situación de violencia prevaleciente en El Salvador, utilizando información para 2007. Tales costos son clasificados en cuatro grandes categorías: i) costos en salud; ii) costos institucionales (legales, judiciales y policiales); iii) costos preventivos en seguridad privada; y iv) pérdidas materiales. Los resultados de las estimaciones efectuadas indican que, en dicho año, la violencia impuso sobre El Salvador un costo económico equivalente a 10,9% del Producto Interno Bruto (PIB) y a más del doble de las asignaciones presupuestarias para Educación y Salud. ABSTRACT: This essay carries out an accounting exercise on the economic costs derived from the violence situation which prevails in El Salvador, using information for 2007. Those costs are classified into four main categories: i) costs on health; ii) institutional costs (legal, judiciary and police); iii) preventive costs for private security; and iv) material losses. The results from the estimations performed indicate that, in 2007, the different expressions and consequences derived from the violence situation imponed on El Salvador an economic cost which was equivalent to 10,9% of Gross Domestic Product (GDP) and more than twice the combined budget allocations to Education and Health.