bluuebunny/crossref_metadata_2025_split huggingface dataset:
BILTENU NA POT
Authors: PODBREGAR IZTOK 
Published: February 2021

Pred vami je prva številka biltena. Pripravili smo ga za uresničevanje zlasti treh
ciljev:
1.	Celoten koncept sodobnega vojaškega managementa sloni na visoko usposobljenih, motiviranih kadrih. Ugotavljamo, da obstoječih prednosti, ki jih nudi velika koncentracija izkušenj in znanja zaposlenih v Slovenski vojski, ne izkoriščamo dovolj. Glasilo nam daje priložnost, da bomo znanja, spoznanja in izkušnje posredovali zaposlenim v Slovenski vojski in tudi širšemu okolju.
2.	Posledica globalizacije in liberalizacije tržišč je, in tudi vedno bo, odhajanje najboljših kadrov iz organizacijskih enot. Z vzpostavitvijo pogojev za razvoj kadrov, katerega del je možnost kreativnega delovanja v obliki objavljanja strokovnih člankov, bomo na nek način vplivali na urejeno prehajanje med organizacijskimi enotami in zaustavljali nekontrolirane odhode iz sistema ter strokovne članke tudi upoštevali pri opredeljevanju predlogov za napredovanje.
3.	Z razporeditvijo na določeno dolžnost pridobi posameznik položajno avtoriteto. Da je bil izbran, je moral izpolnjevati predpisane pogoje, torej imeti formalno izobrazbo, ustrezne delovne izkušnje in zlasti mora biti vojaškostrokovno usposobljen. Navedene pogoje lahko strnemo v strokovno avtoriteto častnika, ki je enakega pomena kot položajna avtoriteta, vendar marsikdaj težje dosegljiva. Prav možnost objavljanja strokovnih člankov v našem glasilu lahko bistveno vpliva na upoštevanje strokovne avtoritete zaposlenih v Slovenski vojski. Vsi bomo imeli možnost strokovnega dokazovanja in s tem nas bodo sodelavci upoštevali kot strokovnjake, hkrati pa bomo tudi strokovno rasli, saj ne bomo objavljali znanih vsebin, pač pa novosti in znanja, spoznanja ter izkušnje iz drugih okolij.

Pričakujem, da bomo izkoristili dano priložnost in želim, da postane glasilo informator vseh zaposlenih, ena pomembnih literatur za izpopolnjevanje zaposlenih v Slovenski vojski, vzpostavljanje organizacijske kulture in tudi razvoj Slovenske vojske.
IMPLEMENTASI PERAKITAN DAN INSTALASI SISTEM OPERASI WINDOWS DAN LINUX
Authors: Irianto Irianto , Afrisawati Afrisawati , Sudarmin Sudarmin , Eska Juna 
Published: February 2021

Abstract: Increased computer users in high school make increasingly also the desire of students / i equal to know the type of computer components. With the many interests of students to know assembling and installation of computers, making their enthusiasm higher in knowing the types of computer applications. Many factors influence for students on computer assembly, such as how component form, type of operating system, type of application, and how to install. Keywords: Computer Components, Operating System, Computer Applications Abstrak: Peningkatan pengguna komputer di sekolah SMA membuat makin meningkat pula keinginan siswa/i sederajat untuk mengetahui jenis komponen komputer. Dengan banyaknya minat siswa/i untuk mengetahui merakit dan instalasi komputer, membuat antusias mereka semakin tinggi dalam mengetahui jenis aplikasi komputer. Banyak faktor yang mempengaruhi bagi siswa/i pada perakitan komputer, seperti bagaimana bentuk komponen, jenis sistem operasi, jenis aplikasi, dan bagaimana cara instalasinya. Kata Kunci : Komponen Komputer, Sistem Operasi, Aplikasi Komputer
PELATIHAN PENGOLAHAN NILAI SISWA UNTUK PEGAWAI DAN GURU PADA SMP NEGERI 5 KISARAN
Authors: Hutahaean Jeperson Hutahaean , Maulana Cecep , Ramadhani Ramadhani , Manurung Nuriadi , Azhar Zulfi , Nofriadi Nofriadi 
Published: February 2021

Abstract: Activities devotion to the community is in the form of training table for the processing of student value for employees and teachers SMP Negeri 5 Kisaran. It aims to provide knowledge, skills, which are expected to result in changes in knowledge, skills and from employees and teachers so that the process of processing student values can run smoothly and easily. Target audiences in community service activities are employees and teachers of SMP Negeri 5 Kisaran. The training activities are presented with lecture, demonstration and question and answer methods. The availability of adequate lecturers, enthusiasm of the participants, and the support of the principal is a support for the implementation of this PKM activity. The obstacles faced is the ability of participants to use this application is still low. Benefits derived from this activity include participants can know about the significance of the use of Micrososft Excel primarily using the table on processing the value of suswa always used by teachers in schools in entering student value and application of basic formula in accelerate the processing of other data. Keywords: Teachers, Microsoft Excel, Student Values, Employees, Tables Abstrak: Kegiatan pengabdian kepada masyarakat ini yaitu berupa pelatihan pembuatan tabel untuk pengolahan nilai siswa bagi pegawai dan guru-guru SMP Negeri 5 Kisaran. Hal ini bertujuan untuk memberikan pengetahuan, keterampilan, yang diharapkan dapat menghasilkan perubahan pengetahuan, keterampilan dan dari para pegawai dan guru sehingga proses pengolahan nilai siswa dapat berjalan dengna lancar dan mudah. Khalayak sasaran dalam kegiatan pengabdian kepada masyarakat ini adalah pegawai dan guru-guru SMP Negeri 5 Kisaran . Kegiatan pelatihan ini disajikan dengan metodeceramah, demonstrasi dan tanya jawab. Ketersediaan dosen yang memadai, antusiasme peserta, dan dukungan kepala sekolah merupakan pendukung terlaksananya kegiatan PKM ini.Adapun kendala yang dihadapi adalah kemampuan peserta menggunakan porgram aplikasi ini masih rendah.Manfaat yang diperoleh dari kegiatan ini antara lain peserta dapat mengetahui tentang arti pentingnya penggunaan Micrososft Excel terutama menggunakan tabel pada pengolahan nilai suswa yang selalu digunakan oleh para guru-guru di sekolah dalam memasukkan nilai siswa dan aplikasi formula dasar dalam mempercepat pengolahan data lainnya. Kata Kunci: Guru,Microsoft Excel, Nilai siswa, Pegawai, Tabel
TIPS DAN TRIK MEMBANGUN RELATIONSHIP DAN QUERY DALAM DATABASE
Authors: Rizaldi Rizaldi , Anggraeni Dewi , Zikra Syah Arridha 
Published: February 2021

Abstract: Knowledge in building a database is one of the foundations for a person to build a computer-based application. In the database itself there are several parts that must be designed to build a database perfectly, ie tables, relationships, and queries. The students of SMK Swasta Nasional Kisaran is one of the objectives that is considered appropriate to understand and practice the science of the database, because the knowledge they can implement directly to their world of work will, of course, work related to the world of information technology, especially building a computer-based information system applications . The method used in learning to build this database, that is training, which in the training contains the study of database in theory, then practice directly using Microsoft Access 2007 application. The end result of this learning is the students of SMK Swasta Nasional Kisaran can know, understand, and practice directly on the computer using Microsoft Access 2007 applications, how tips and tricks to build tables, relationships, and queries, so that the database can be created perfectly.Keywords: Database, Table, Relationship, QueryAbstrak: Pengetahuan dalam membangun database merupakan salah satu dasar bagi seseorang untuk membangun sebuah aplikasi berbasis komputer. Dalam database itu sendiri terdapat beberapa bagian-bagian yang harus dirancang untuk terbangunnnya sebuah database dengan sempurna, yaitu tabel, relationship, dan query. Siswa SMK Swasta Nasional Kisaran salah satu sasaran yang dianggap tepat untuk memahami dan mempraktekan ilmu pengetahuan tentang database, karena pengetahuan tersebut dapat mereka implementasikan langsung pada dunia kerja mereka nantinya, tentunya pekerjaan yang berkaitan dengan dunia teknologi informasi, khususnya membangun sebuah aplikasi sistem informasi berbasis komputer. Metode yang digunakan dalam pembelajaran membangun sebuah database ini, yaitu pelatihan, yang di dalam pelatihan tersebut memuat tentang kajian database secara teori, kemudian praktek langsung menggunakan aplikasi Microsoft Access 2007. Hasil akhir dari pembelajaran ini adalah siswa SMK Swasta Nasional Kisaran dapat mengetahui, memahami, dan mempraktekkan langsung pada komputer menggunakan aplikasi Microsoft Access 2007, bagaimana tips dan trik membangun tabel, relationship, dan query, sehingga database dapat tercipta dengan sempurna. Kata kunci: Database, Tabel, Relationship, Query
Leonurine Promotes the Osteoblast Differentiation of Rat BMSCs by Activation of Autophagy via the PI3K/Akt/mTOR Pathway
Authors: Zhao Bingkun , Peng Qian , Poon Enoch Hin Lok , Chen Fubo , Zhou Rong , Shang Guangwei , Wang Dan , Xu Yuanzhi , Wang Raorao , Qi Shengcai 
Published: February 2021

BackgroundLeonurine, a major bioactive component from Herba leonuri, has been shown to exhibit anti-inflammatory and antioxidant effects. The aim of this study was to investigate the effect of leonurine on bone marrow-derived mesenchymal stem cells (BMSCs) as a therapeutic approach for treating osteoporosis.Materials and MethodsRat bone marrow-derived mesenchymal stem cells (rBMSCs) were isolated from 4-weeks-old Sprague–Dawley rats. The cytocompatibility of leonurine on rBMSCs was tested via CCK-8 assays and flow cytometric analyses. The effects of leonurine on rBMSC osteogenic differentiation were analyzed via ALP staining, Alizarin red staining, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blot. Additionally, autophagy-related markers were examined via qRT-PCR and Western blot analyses of rBMSCs during osteogenic differentiation with leonurine and with or without 3-methyladenine (3-MA) as an autophagic inhibitor. Finally, the PI3K/Akt/mTOR signaling pathway was evaluated during rBMSC osteogenesis.ResultsLeonurine at 2–100 μM promoted the proliferation of rBMSCs. ALP and Alizarin red staining results showed that 10 μM leonurine promoted rBMSC osteoblastic differentiation, which was consistent with the qRT-PCR and Western blot results. Compared with those of the control group, the mRNA and protein levels of Atg5, Atg7, and LC3 were upregulated in the rBMSCs upon leonurine treatment. Furthermore, leonurine rescued rBMSC autophagy after inhibition by 3-MA. Additionally, the PI3K/AKT/mTOR pathway was activated in rBMSCs upon leonurine treatment.ConclusionLeonurine promotes the osteoblast differentiation of rBMSCs by activating autophagy, which depends on the PI3K/Akt/mTOR pathway. Our results suggest that leonurine may be a potential treatment for osteoporosis.
Identification of Core Genes Related to Progression and Prognosis of Hepatocellular Carcinoma and Small-Molecule Drug Predication
Authors: Jiang Nan , Zhang Xinzhuo , Qin Dalian , Yang Jing , Wu Anguo , Wang Long , Sun Yueshan , Li Hong , Shen Xin , Lin Jing , Kantawong Fahsai , Wu Jianming 
Published: February 2021

BackgroundHepatocellular carcinoma (HCC) is one of the most leading causes of cancer death with a poor prognosis. However, the underlying molecular mechanisms are largely unclear, and effective treatment for it is limited. Using an integrated bioinformatics method, the present study aimed to identify the key candidate prognostic genes that are involved in HCC development and identify small-molecule drugs with treatment potential.Methods and ResultsIn this study, by using three expression profile datasets from Gene Expression Omnibus database, 1,704 differentially expressed genes were identified, including 671 upregulated and 1,033 downregulated genes. Then, weighted co-expression network analysis revealed nine modules are related with pathological stage; turquoise module was the most associated module. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway analyses (KEGG) indicated that these genes were enriched in cell division, cell cycle, and metabolic related pathways. Furthermore, by analyzing the turquoise module, 22 genes were identified as hub genes. Based on HCC data from gene expression profiling interactive analysis (GEPIA) database, nine genes associated with progression and prognosis of HCC were screened, including ANLN, BIRC5, BUB1B, CDC20, CDCA5, CDK1, NCAPG, NEK2, and TOP2A. According to the Human Protein Atlas and the Oncomine database, these genes were highly upregulated in HCC tumor samples. Moreover, multivariate Cox regression analysis showed that the risk score based on the gene expression signature of these nine genes was an independent prognostic factor for overall survival and disease-free survival in HCC patients. In addition, the candidate small-molecule drugs for HCC were identified by the CMap database.ConclusionIn conclusion, the nine key gene signatures related to HCC progression and prognosis were identified and validated. The cell cycle pathway was the core pathway enriched with these key genes. Moreover, several candidate molecule drugs were identified, providing insights into novel therapeutic approaches for HCC.
Differential Elevation of Inflammation and CD4+ T Cell Activation in Kenyan Female Sex Workers and Non-Sex Workers Using Depot-Medroxyprogesterone Acetate
Authors: Omollo Kenneth , Lajoie Julie , Oyugi Julius , Wessels Jocelyn M. , Mwaengo Dufton , Kimani Joshua , Kaushic Charu , Fowke Keith R. 
Published: February 2021

BackgroundDepot Medroxyprogesterone (DMPA) is one of the most widely used contraceptives in Sub-Saharan Africa where HIV incidence is high. We explored the effect of DMPA on the activation of HIV cellular targets and inflammation as a possible mechanism of increased HIV risk with DMPA use. Since sex work is known to affect the immune system, this study aimed to understand the effect of DMPA on the immune system among sex workers and non-sex worker women.MethodsTwenty-seven DMPA-using HIV seronegative female sex workers (FSW) and 30 DMPA-using HIV seronegative non-sex worker (SW) women were enrolled in the study. Twenty-four FSWs and 30 non-sex workers who were not using any hormonal contraception (no HC) were recruited as controls. Blood and cervico-vaginal samples were collected from all participants and assayed for T cell activation and proinflammatory cytokines.ResultsAmong no HC users, sex workers had lower expression of CD38 and CD69 on blood-derived CD4+ T cells along with lower CD4+CCR5+ cells frequency in the endocervix. Plasma MCP-1, TNFα and IL-17 also had reduced expression in FSW not using HC. Non-sex workers using DMPA had elevated proportions of blood-derived CD4+CD38+, CD4+CD69+ and CD4+HLA-DR+ T cells relative to non-sex workers who were not taking any HC. DMPA-using non-sex workers also had an increased level of plasma interferon gamma (IFN-γ), monokine induced by interferon-γ (MIG) and sCD40L, alongside higher proportion of CD4+CD38+ and CD4+CD69+ T cells at the cervix compared to non-sex workers no-HC controls., Finally, non-sex workers and FSWs using DMPA had similar levels of genital and peripheral CD4+ T cell activation and inflammation.ConclusionDMPA increased inflammation and expression of activation markers on potential HIV target cells in non-sex workers. These data show that DMPA is a strong immune modulator and its use counteracts the decreased immune activation associated with sex work. These findings suggest that inflammation and increased HIV target cells in blood and at the genital tract may be mechanisms by which DMPA increases susceptibility to HIV.
Association Between Vitamin D Exposure and Head and Neck Cancer: A Systematic Review With Meta-Analysis
Authors: Pu Yuting , Zhu Gangcai , Xu Yimin , Zheng Siyuan , Tang Bin , Huang Huimei , Wu Irene X. Y. , Huang Donghai , Liu Yong , Zhang Xin 
Published: February 2021

BackgroundVitamin D deficiency is a well-described preventable cause of many cancers; the association of vitamin D use with the development of head and neck cancer (HNC) is not clear. We aim to conduct a systematic review of the studies assessing the relation between vitamin D exposure and the prevention and prognosis of the HNC using meta-analysis.MethodsPubMed, EMBASE, Cochrane Library, Web of Science up to 1 January 2021, and reference lists of related studies were searched. We extracted observational studies reporting the association between vitamin D (vitamin D receptor gene polymorphisms, 25-hydroxyvitamin D concentrations, and vitamin D intake) and the outcomes of interest (HNC incidence and HNC mortality) in HNC patients aged 18 or older. Fixed effects models were used to calculate pooled effect sizes and 95% confidence intervals (CIs) by RevMan (version 5.3).ResultsSixteen studies with a total of 81,908 participants were enrolled in our meta-analysis. Based on the pooled genomic analysis, comparing with participants with the genotypes of Ff + FF or FF, the pooled odds ratio (OR) of participants with the genotype of ff was 0.77 (95% CI: 0.61 to 0.97) and 0.75 (0.58 to 0.97), respectively. A similar trend was noted when comparing tt with Tt + TT or TT, in which OR (95% CI) was 0.70 (0.55 to 0.90) and 0.72 (0.55 to 0.95). No significant association was identified between BsmI polymorphism and HNC. Furthermore, the OR of HNC incidence was 0.77 (0.65 to 0.92) for participants with vitamin D intake over the ones with a regular diet. High concentrations of circulated 25-hydroxyvitamin D (25-OHD) significantly decreased by 32% of HNC incidence (OR (95% CI): 0.68 (0.59 to 0.78)) and increased HNC survival (pooled hazard ratio 1.13, 1.05 to 1.22) during a 4–5 years follow-up. High concentrations of circulating 25-OHD in patients with HNC led to a decreased risk of mortality to 0.75 (0.60 to 0.94) as the follow-up extends to 8–12 years.ConclusionsElevated activities of vitamin D by diet intake, genomic polymorphisms, or circulated 25-OHD may protect people from HNC and improve the prognosis of patients with HNC.Systematic Review RegistrationPROSPERO, identifier CRD42020176002 (https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=176002).
Identification of a Novel Serum Proteomic Signature for Primary Sjögren’s Syndrome
Authors: Padern Guillaume , Duflos Claire , Ferreira Rosanna , Assou Said , Guilpain Philippe , Maria Alexandre Thibault Jacques , Goulabchand Radjiv , Galea Pascale , Jurtela Maja , Jorgensen Christian , Pers Yves-Marie 
Published: February 2021

ContextPrimary Sjögren’s syndrome (pSS) is a complex heterogeneous autoimmune disease (AID) which can mimic rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). Our exploratory study investigated serum biomarkers that may discriminate pSS from RA and SLE.MethodsSerum concentrations of 63 biomarkers involved in immune cell trafficking, inflammatory response, cellular movement, and cell-to-cell signaling were measured in AID patients, included prospectively into the study at the Montpellier University Hospital. A multivariate analysis by multiple logistic regression was performed, and discriminative power assessed using logistic regression adjusted on significant demographic factors.ResultsAmong the 95 patients enrolled, 42 suffered from pSS, 28 from RA, and 25 from SLE. Statistical analysis showed that concentrations of BDNF (OR = 0.493 with 95% CI [0.273–0.891]; p = 0.0193) and I-TAC/CXCL11 (OR = 1.344 with 95% CI [1.027–1.76]; p = 0.0314) can significantly discriminate pSS from RA. Similarly, greater concentrations of sCD163 (OR = 0.803 with 95% CI [0.649–0.994]; p = 0.0436), Fractalkine/CX3CL1 (OR = 0.534 with 95% CI [0.287–0. 991]; p = 0.0466), MCP-1/CCL2 (OR = 0.839 with 95% CI [0.732–0.962]; p = 0.0121), and TNFa (OR = 0.479 with 95% CI [0.247–0.928]; p = 0.0292) were associated with SLE diagnosis compared to pSS. In addition, the combination of low concentrations of BDNF and Fractalkine/CX3CL1 was highly specific for pSS (specificity 96.2%; positive predictive value 80%) compared to RA and SLE, as well as the combination of high concentrations of I-TAC/CXCL11 and low concentrations of sCD163 (specificity 98.1%; positive predictive value 75%).ConclusionOur study highlights biomarkers potentially involved in pSS, RA, and SLE pathophysiology that could be useful for developing a pSS-specific diagnostic tool.
Validation of Computer-Adaptive Contrast Sensitivity as a Tool to Assess Visual Impairment in Multiple Sclerosis Patients
Authors: Rosenkranz Sina C. , Kaulen Barbara , Zimmermann Hanna G. , Bittner Ava K. , Dorr Michael , Stellmann Jan-Patrick 
Published: February 2021

BackgroundImpairment of visual function is one of the major symptoms of people with multiple sclerosis (pwMS). A multitude of disease effects including inflammation and neurodegeneration lead to structural impairment in the visual system. However, the gold standard of disability quantification, the expanded disability status scale (EDSS), relies on visual assessment charts. A more comprehensive assessment of visual function is the full contrast sensitivity function (CSF), but most tools are time consuming and not feasible in clinical routine. The quantitative CSF (qCSF) test is a computerized test to assess the full CSF. We have already shown a better correlation with visual quality of life (QoL) than for classical high and low contrast charts in multiple sclerosis (MS).ObjectiveTo study the precision, test duration, and repeatability of the qCSF in pwMS. In order to evaluate the discrimination ability, we compared the data of pwMS to healthy controls.MethodsWe recruited two independent cohorts of MS patients. Within the precision cohort (n = 54), we analyzed the benefit of running 50 instead of 25 qCSF trials. The repeatability cohort (n = 44) was assessed by high contrast vision charts and qCSF assessments twice and we computed repeatability metrics. For the discrimination ability we used the data from all pwMS without any previous optic neuritis and compared the area under the log CSF (AULCSF) to an age-matched healthy control data set.ResultsWe identified 25 trials of the qCSF algorithm as a sufficient amount for a precise estimate of the CSF. The median test duration for one eye was 185 s (range 129–373 s). The AULCSF had better test–retest repeatability (Mean Average Precision, MAP) than visual acuity measured by standard high contrast visual acuity charts or CSF acuity measured with the qCSF (0.18 vs. 0.11 and 0.17, respectively). Even better repeatability (MAP = 0.19) was demonstrated by a CSF-derived feature that was inspired by low-contrast acuity charts, i.e., the highest spatial frequency at 25% contrast. When compared to healthy controls, the MS patients showed reduced CSF (average AULCSF 1.21 vs. 1.42, p &lt; 0.01).ConclusionHigh precision, usability, repeatability, and discrimination support the qCSF as a tool to assess contrast vision in pwMS.