bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bacterial community structure and functional profiling of high Arctic fjord sediments
Authors: Vishnupriya S , T JABIR , Krishnan K.P , Hatha Abdulla Mohamed 
Published: June 2021

Abstract
Kongsfjorden, an Arctic fjord is significantly affected by the glacier melt and Atlantification, both the processes driven by accelerated warming in the Arctic. This has lead to changes in primary production, carbon pool and microbial communities, especially that in the sediment. In this study, we have examined the bacterial community structure of surface (0–2 cm) and subsurface (3–9 cm) sediments of Kongsfjorden using the high throughput sequencing analysis. Results revealed that bacterial community structure of Kongsfjorden sediments were dominated by phylum Proteobacteria followed by Bacteroidetes and Epsilonbacteraeota. While α- and γ- Proteobacterial class were dominant in surface sediments; δ- Proteobacteria were found to be predominant in subsurface sediments. The bacterial community structure in the surface and subsurface sediments showed significant variations (p ≤ 0.05). Total organic carbon could be one of the major parameters controlling the bacterial diversity in the surface and subsurface sediments. Functional prediction analysis indicated that the bacterial community could be involved in the degradation of complex organic compounds such as glycans, glycosaminoglycans, polycyclic aromatic hydrocarbons and also in the biosynthesis of secondary metabolites.
Evaluation and prioritisation of potential locations for investment in dental tourism
Authors: Ahmadimanesh Fatemeh , Pourmehdi Mohammad , Paydar Mohammad Mahdi 
Published: June 2021

Abstract
Medical tourism had notable growth in the past few years, and it is understood that one of the most prevalent types of medical tourism is dental tourism. This study aims to select the most suitable city for investment in dental tourism. Five dimensions and nineteen criteria associated with dental tourism have been specified, and the DEMATEL-based ANP (DANP) is used to determine the interrelation of criteria and compute their weights. Then, the VIKOR is used to evaluate the suitability of different cities for investment in dental tourism and determine the potential areas of the selected cities that need enhancement. A case study is conducted to present the applicability of the suggested model. The results indicate that the dental facilities and service is the most critical dimension, and reputation of hospital/facility and doctors, dental clinics with certification/accreditation scheme are the most important criteria for analysing the suitability of potential locations.
Effects of Cervical Manual Therapy Versus Conventional Physical Therapy on Clinical Outcomes in People With Carpal Tunnel Syndrome: A Study Protocol for a Randomized Controlled Trial
Authors: Zarrin Milad , saadat maryam , Shaterzadeh Mohammad Jafar , Ahmadi Davood Shalil 
Published: June 2021

Abstract
BackgroundCarpal tunnel syndrome (CTS) is the most common entrapment neuropathy. A recent systematic review described limited or no evidence about the conservative interventions. Literature has expressed that more proximal area such as the cervical spine is involved in CTS. Therefore, the aim of this study is to examine the effects of combination cervical manual therapy and conventional physical therapy on pain, self-reported function, and electrophysiological findings in the management these patients.MethodsThis study will be a double-blind, parallel-group, randomized, controlled trial (RCT) in which carpal tunnel syndrome subjects randomize to either conventional or combined exercise groups. The conventional group take routine physical therapy treatments, while patients in combine exercise group receive cervical manual therapy plus routine physical therapy treatments. All patients receive 10 sessions of supervised intervention. The outcome measures included visual analogue scale (VAS), Boston Carpal Tunnel and DASH questionnaire, motor distal latencies and sensory nerve conduction velocity of median nerve. They obtain pre- and post-intervention. DiscussionThe findings of this study will provide knowledge about the comparison effectiveness of conventional physical therapy with and without cervical manual therapy on symptom severity, functional status, disability, velocity and latency median nerve in patients with CTS.Trial registrationIranian Registry of Clinical Trials, IRCT20201201049565N1. Registered on 15 December 2020.
Attributes, Supportive and Core Functions of Public Health Emergency Surveillance leadership, and Implementation for Tropical Diseases Control
Authors: yenew chalachew , Mulatu Sileshi 
Published: June 2021

Abstract
BackgroundPublic health surveillance (PHS) is the continuing organized gathering, investigation, elucidation, and well-timed distribution of health-related information for activities and program evaluation. Conducting a surveillance system evaluation is crucial for monitoring the efficacy and effectiveness of intervention programs in health care systems. Evaluate the Status of Attributes, Supportive and Core Functions implementation of Public Health Emergency Surveillance (PHES) in the case of Awi Zone, Amhara Regional State, Ethiopia, 2020 was the main aim of the study.Methods A descriptive prevalence study design was used to evaluate the surveillance system of the Awi zone selected woreda. 25 study sources are used in the study (5 District Health Offices (5HOs), 10 Health Centers (10HCs), and 10 Health Posts (10HPs)). Purposive sampling techniques were utilized. Data were obtained by communicable diseases control the standard format of systematic evaluation of four surveillance units from January to August 2020 through observation, document review, and interviewing surveillance officers and focal persons using a semi-structured survey.ResultsThe structure of public health surveillance (PHS) data flow from health posts to health districts be sound structured. However, coordination and supervision of the surveillance activities were not frequent. From those supervised health facilities, most of them are not receiving feedback. There was no budget line, written feedback, epidemic and preparedness, and a response plan regular based on supportive supervision at all visited health facilities. ConclusionsSupervisions were made as integrated supportive supervision in the last six months. However, there was no program-specific supportive supervision of Public Health Emergency Management (PHEM). Data analysis was not routinely practiced in both visited districts and was not used for decision making. Therefore, we recommend that districts and sub-city health offices should conduct regular surveillance data analysis, perform supportive supervision, avail budgets, and mitigate resource constraints and improve data quality on the job training and supportive supervision.
Single vs. Double Intracoronary Injection of Mesenchymal Stromal Cell after Acute Myocardial Infarction: The Study Protocol from a Randomized Clinical Trial. BOOSTER-TAHA7 trial
Authors: Attar Armin , Nouri Fatemeh , Yazdanshenas Arash , Hessami Kamran , Vosough Massoud , Abdi-Ardekani Alireza , Izadpanah Peyman , Ramzi Mani , Kojouri Javad , Pouladfar Gholamreza , Monabati Ahmad 
Published: June 2021

Abstract
BackgroundMeta-analysis from previous studies have shown that treatment with Mesenchymal stromal cell (MCSs) may increase the left ventricular ejection fraction (LVEF) after acute myocardial infarction (AMI) by 3.84% and the effect is greater in those who are not aged and have developed a reduced LVEF. However, it seems that MSC transplantation does its effect through an indirect paracrine effect and direct differentiation to the cardiomyocytes does not occur. Therefore, it can be hypothesized that this paracrine effect would be augmented if repeated doses of MSC are transplanted. This study is conducted to compare single vs. double injection of MSCs.MethodsThis is a single-blind, randomized, multicenter trial aiming to determine whether intracoronary infusion of double doses of umbilical cord-derived Wharton’s jelly MSCs (WJ-MSCs) improves LVEF more after AMI compared to single administration. The study will enroll 60 AMI 3 to 7 days after AMI. The patients should be under 65 years old and have a severe impairment in LV function (LVEF < 40%). They will be randomized to three arms receiving single or double doses of intracoronary infusion of WJ-MSCs or placebo. Primary endpoint of this study is assessment of improvement in LVEF at 6-month post intervention as compared to the baseline. DiscussionThis investigation will help to determine whether infusion of booster (second) dose of intracoronary WJ-MSCs in patients with AMI will contribute to increasing its effect on the improvement of myocardial function.Trial registrationIRCT20201116049408N1. (www.IRCT.ir)
Survival Analysis Of 335 Patients With Colorectal Cancer Undergoing Combined Treatment
Authors: Moradi Ghobad , Rasouli Mohammad Aziz , Roshani Daem 
Published: June 2021

Abstract
Purpose: If colorectal cancer (CRC) is diagnosed in the early stages, the patients will have higher survival rates. Although there might be some other factors which affect the survival rate, the kind of treatment available based on existing health and therapeutic facilities, is very important as well. The aim of this study was to explore the best type of treatment in colorectal cancer patients.Methods: The data of 335 patients with CRC in Kurdistan province were collected using population-based cancer registration system from first of March 2009 to 2014. Demographic and clinical- pathologic data of the patients were gathered through their medical and pathology records and going to the door of their houses. The cancer-specific survival rate were calculated using Kaplan-Meier survival curve, log-rank test, univariate and multivariate Cox regression. The data was analyzed using Stata 12 software. Results: One-year, three-year and five-year survival rates were %87, %57 and %33 respectively. The median of survival was 42.6 months. The five-year survival rate for those patients who had received both surgical and chemotherapy treatments was %55.8. There was less mortality rate among the patients who had received both surgical and chemotherapy treatments compared to those who had not received any treatment (HR=0.57, 95% CI 0.24-0.93).Conclusion: When CRC patients are treated using both surgical and chemotherapy treatments, they will have higher survival rate. Therefore, it is suggested to use both treatments for CRC patients.
Analysis of Multi-Story Buildings with Hybrid Shear Wall - Steel Bracing Structural System
Authors: Sharma Shubam , Tiwary Aditya Kumar 
Published: June 2021

Abstract
Numerous studies were contemplated on the structures with distinctive structural configuration and ample amount of work is currently being performed through the investigation of the response of individual behavior of shear walls and bracings by varying configurations and their material properties. Seismic design philosophies had mentioned firmly that a structure must accomplish Life Safety (LS) and Performance Level (PL) for both reinforced concrete and steel structures. This study is anchored on prevailing lateral load resisting system which is virtuous but not adequate to retain vigorous ground motion or acceleration. To overwhelm this problem, an attempt was made to familiarize a new lateral load resisting system formulated by the amalgamation of two different existing lateral load resisting systems, specifically shear walls and bracings. The hybrid structural system embraces two distinctive lateral load resisting techniques, shear walls, and bracings for moment-resisting frame. A numerical finite element study was carried out by the linear dynamic method on the response of structure subjected to seismic condition and an optimal configuration of the different structural patterns is assured by using numerous possible patterns of a hybrid structural system using finite element-based software. The criteria contemplated for study including time period, base shear, overturning moment, story drift ratio, and story displacement are compared with different models and the optimal structure is concluded based upon the recital. The comparative results revealed that there is a reduction noticed in the fundamental time period, and story displacement, where as there is negligible increment in base shear and overturning moment for the hybrid structural system as compared to other configurated models.
Multicolor Emission from Ultraviolet GaN-based Photonic Quasicrystal Nanopyramid Structure with Semipolar InxGa1-xN/GaN Multiple Quantum Wells
Authors: Chen Cheng-Chang , Lin Hsiang-Ting , Chang Shih-Pang , Kuo Hao-Chung , Hung Hsiao-Wen , Chien Kuo-Hsiang , Chang Yu-Choung , Shih Min-Hsiung 
Published: June 2021

Abstract
In this study, we demonstrated large-area high quality multi-color emission from the 12-fold symmetric GaN photonic quasicrystal nanorod device which was fabricated using the nanoimprint lithography technology and multiple quantum wells regrowth procedure. High-efficiency blue and green color emission wavelengths of 460 and 520 nm from the regrown InxGa1−xN/GaN multiple quantum wells were observed under optical pumping conditions. To confirm the strongly coupling between the quantum well emissions and the photonic crystal band-edge resonant modes, the finite-element method (FEM) was applied to perform a simulation of the 12-fold symmetry photonic quasicrystal lattices.
Medical research conduct and publication during higher education in Syria: attitudes, barriers, practices, and possible solutions
Authors: Hanafi Ibrahem , Kassem Luma Haj , Hanafi Mouaz , Ahmad Sulafa , Abbas Ola , Hajeer Mohammad Younis , Alahdab Fares 
Published: June 2021

Abstract

Introduction:The huge workload on doctors especially residents, who are the main healthcare providers in public hospitals, in addition to the vanishing incomes and lack of personal safety during the decade-long Syrian crisis, led to further hurdles for the focus on research. Postgraduate students in the medical and paramedical fields must conduct original research projects as part of their graduation requirements. However, that does not reflect on the research publications coming from Syria.Methods:A nation-wide cross-sectional study targeting medical, dental, and pharmacy postgraduate students who are at the phase of planning for their required projects. The questionnaire aimed to capture their attitudes towards research, perceived barriers, and previous research experiences.Results:The sample consisted of 429 residents representing about 22% of the target population. Nearly all the participants had positive opinion towards the important role of medical research and the significance of their participation. Agreement was also clear regarding perceived barriers including the lack of adequate training, and research facility. Seventy-one percent of the participants were not involved in any research before the time of their master theses, less than 13% of them had submitted an article for publication, and less than 5% had submitted more than one paper. Poor internet connectivity and poor reading and writing English skills were decisive negative factors in previous research experiences. Mentors’ support and self-paced learning of research skills had a significant positive impact on students’ research contributions with odds ratios of 2.04 [1.02-4.06] (P<0.001) and 2.68 [1.48-4.84] (P<0.001) respectively.Conclusion:The attitudes of postgraduate students towards research were quite positive but hindered by several obstacles. Further integration of research practical training in the curricula, allowing long-distance mentoring, enhancing collaboration between peers, as well as narrowing the distance between students and mentors may significantly boost research productivity in Syria despite the conflicts.
Spatial-Temporal Variations for Pollution Assessment of Heavy Metals in Hengshui Lake of China
Authors: Liu Weiwei , Guo Ziliang , Wang Henian , Wang Daan , Zhang Manyin 
Published: June 2021

Abstract
A comprehensive analysis of the spatial and temporal variations of heavy metals in wetland sediment can delineate the changes in possible contamination sources, providing valuable conservation strategies for further wetland management. Using pollution index, enrichment factors, and potential ecological risk index, the spatial and temporal variations in heavy metals (Cd, Hg, As, Pb, Cr, Cu, and Zn) were evaluated in Hengshui Lake in north China from 2005 to 2020. The results demonstrated that the concentrations and assessment index for most heavy metals all decreased, with that of As decreasing the most (-54.3%), which mainly benefited from the implementation of a series of ecological conservation and restoration projects. Although the assessment indexes for most heavy metals indicated non-pollution status, Hg and Cd exhibited medium enrichment and moderate potential ecological risk. Especially for Cd, the related-indexes increased by 859.3%. Furthermore, the high pollution was mainly distributed nearby the regions of dense enterprises and the spilled into of water (i.e., Wangkou sluice, the Jizhou Small Lake and its causeway). This was primarily attributed to discharge of industrial wastewater and Cd-polluted ecological diversion water. These findings demonstrated the necessity of continued and targeted implementation of wetland conservation and restoration projects, identified possible contamination sources and important pollution regions that could provide insights into contamination control options and targeted management strategies for Hengshui Lake.
miR-145-5p: A Potential Biomarker in Predicting Gleason Upgrading of Prostate Biopsy Samples Scored 3+3=6
Authors: Wang Tao , Dong Lei , Sun Juanjuan , Shao Jiangliang , Zhang Jian , Chen Siteng , Wang Chaofu , Wang Xiang 
Published: June 2021

Abstract
Background: The Gleason grading system is a major tool used for prediction of prostate cancer (PCa) behavior. Because of heterogeneity and sampling errors, prognosis is variable even among patients with the same Gleason score (GS). Therefore, more accurate biomarkers that complement the Gleason system are needed to improve the clinical management of PCa.Methods: Formalin-fixed, paraffin embedded tissue samples were obtained from radical prostatectomy (RP) (patient set 1, n=53) and needle biopsy (patient set 2, n=107; patient set 3, n=119). Cancer tissues from pure regions of each Gleason pattern (GP) were separately collected using laser-captured microdissection, followed by Real-time-PCR to determine the relative expression of miRNAs, including miR-1-5p, miR-21-5p, miR-30d-5p, miR-100-5p, miR-145-5p, miR-224-5p, and miR-708-5p. miRNA’s association with Gleason upgrading (GU) was evaluated using receiver operator characteristics (ROC) curve and multivariate logistic regression analysis. The integrated miRNA targets prediction and enrichment analyses were performed to determine the potential functions of miRNA. Results: It was found that miR-145-5p in GP3 from radical prostatectomy (RP) were overexpressed in patients with GS6 PCa compared with GS7 patients, which was further confirmed in a larger biopsy cohort. ROC curve analysis revealed that miR-145-5p in biopsy was significantly associated with GU upon RP. In multivariate analyses, miR-145-5p was an independent predictor of GU. Conclusions: Our study indicated that differential expression of miRNAs existed in GP3 from pure GS6 and GS7 PCa, highlighting a path toward the clinical use of miRNAs in predicting GU and assisting in treatment modality selection.
Effect of Educational Intervention Based on Self-Efficacy Theory on The Caring Behavior of Mothers Having Children with Cancer
Authors: Barani Maryam , Hassani Laleh , Ghanbarnejad Amin , Molavi Mohammad Ali 
Published: June 2021

Abstract
Background

Self-efficacy, as one of the concepts of empowerment model, plays a role in increasing the caring behavior. Accordingly, the present study aimed to evaluate the effect of educational intervention based on self-efficacy theory on the caring behavior of mothers having children with cancer.
Methods

This before-after clinical trial study was conducted on all mothers (N = 86) of children with cancer undergoing chemotherapy who referred to Bandar Abbas Children's Hospital. All mothers participate in four educational intervention sessions. The Shearer's self-efficacy questionnaire and "mothers caring behavior scale" were completed at the 1rst and 3rd and 6th months after intervention. Descriptive statistics, paired t-test, analysis of variance (ANOVA) with repeated measures and a linear mixed model were used to assess the effect of time and self-efficacy on the caring behavior adjusting for family size, mother’s age, mother’s job, mother’s education, and chemo-therapy session.
Results

The results indicated a significant difference in the mean score of mothers' self-efficacy after intervention (P < 0.001). Besides, the two-way self-efficacy score of the first and second follow-ups was p = 0.096. Furthermore, the mean score of caring behavior before and after the intervention indicated a significant difference (P < 0.001).
Conclusion

The results of the present study indicated that an educational program for mothers increased their caring behavior and self-efficacy with the increase of self-efficacy, mothers' caring behavior was promoted. Authorities and practitioners are suggested to pay more attention to designing educational programs based on health models and theories.
Modulation of α7nAchR by Melatonin Alleviates Ischemia and Reperfusion-Compromised Integrity of Blood Brain Barrier through Inhibiting HMGB1-Mediated Microglia Activation and CRTC1-Mediated Neuronal Loss
Authors: Chen Shuang , Sun Yanyun , Li Fei , Zhang Xinyu , Hu Xiaoyan , Zhao Xiaoyun , Li Yixuan , Li Hui , Zhang Jianliang , Liu Wenlan , Zheng Guoqing , Jin Xinchun 
Published: June 2021

Abstract
The only food and drug administration (FDA)-approved drug currently available for the treatment of acute ischemic stroke is tissue plasminogen activator (tPA), yet the therapeutic benefits of this drug are partially outweighed by the increased risk of hemorrhagic transformation (HT). Analysis of the NIH trial has shown that cigarette smoking protected tPA-treated patients from HT, however, the underlying mechanism is not clear. Nicotinic acetylcholine receptors (nAChR) has shown anti-inflammatory effect and modulation nAChR could be a strategy to reduce ischemia/reperfusion-induced blood brain barrier (BBB) damage. Since melatonin could regulate the expression of α7nAchR and melatonin’s neuroprotective effect against ischemic injury is mediated via α7nAChR modulation, here, we aim to test the hypothesis that melatonin reduces ischemia and reperfusion (I/R)-induced BBB damage through modulation of α7nACh receptor (α7nAChR). Mice were subjected to 1.5 h ischemia and 24 h reperfusion and at the onset of reperfusion, mice received intraperitoneal administration (i.p.) of either drug or saline. Mice were randomly assigned into five groups: Saline; α7nAChR agonist PNU282987; Melatonin; Melatonin + Methyllycaconitine (MLA, α7nAChR antagonist) and MLA group. BBB permeability was assessed by detecting the extravasation of Evan’s blue and IgG. Our results showed that I/R significantly increased BBB permeability accompanied by occludin degradation, microglia activation, and high mobility group box 1 (HMGB1) release from the neuron. In addition, I/R significantly induced neuronal loss accompanied by the decrease of CREB regulated transcriptional coactivator 1 (CRTC1) and p-CREB expression. Melatonin treatment significantly inhibited the above changes through modulating α7nAChR. Taken together, these results demonstrate that melatonin provides a protective effect on ischemia/reperfusion-induced BBB damage, at least in part, depending on modulation of α7nAChR.