bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical treatment of recalcitrant gastroesophageal reflux disease in patients with systemic sclerosis: a systematic review
Authors: Aiolfi Alberto , Nosotti Mario , Matsushima Kazuhide , Perali Carolina , Ogliari Cristina , Del Papa Nicoletta , Bonitta Gianluca , Bona Davide 
Published: February 2021

Abstract
Introduction
Gastroesophageal reflux disease (GERD) is frequently seen in patients with systemic sclerosis (SSc). Long-standing GERD may cause esophagitis, long-segment strictures, and Barrett’s esophagus and may worsen pre-existing pulmonary fibrosis with an increased risk of end-stage lung disease. Surgical treatment of recalcitrant GERD remains controversial. The purpose of this systematic review was to summarize the current data on surgical treatment of recalcitrant GERD in SSc patients.

Materials and methods
A systematic literature review according to PRISMA and MOOSE guidelines. PubMed, EMBASE, and Web of Science databases were consulted.

Results
A total of 101 patients were included from 7 studies. The age ranged from 34 to 61 years and the majority were females (73.5%). Commonly reported symptoms were heartburn (92%), regurgitation (77%), and dysphagia (74%). Concurrent pulmonary disease was diagnosed in 58% of patients. Overall, 63 patients (62.4%) underwent open fundoplication, 17 (16.8%) laparoscopic fundoplication, 15 (14.9%) Roux en-Y gastric bypass (RYGB), and 6 (5.9%) esophagectomy. The postoperative follow-up ranged from 12 to 65 months. Recurrent symptoms were described in up to 70% and 30% of patients undergoing fundoplication and RYGB, respectively. Various symptoms were reported postoperatively depending on the type of surgical procedures, anatomy of the valve, need for esophageal lengthening, and follow-up.

Conclusions
The treatment of recalcitrant GERD in SSc patients is challenging. Esophagectomy should be reserved to selected patients. Minimally invasive RYGB appears feasible and safe with promising preliminary short-term results. Current evidence is scarce while a definitive indication about the most appropriate surgical treatment is lacking.
Geologische, hydrogeologische und anthropogene Einflüsse auf die Wasserchemie der Möhlin, Schwarzwald – eine Momentaufnahme
Authors: Nitzsche Niels , Siebel Wolfgang , Stober Ingrid 
Published: February 2021

ZusammenfassungDiese Arbeit untersucht die geologischen, hydrogeologischen und anthropogenen Einflüsse auf die chemische Zusammensetzung eines Flusses, am Beispiel der Möhlin. Wasserproben wurden an verschiedenen Flussabschnitten genommen und mittels Alkalinitätstest und Ionenchromatographie auf die Ionen Ca2+, Mg2+, Na+, K+, HCO3−, CO32−, SO42−, Cl−, F− und NO3− untersucht. Daneben wurden Leitfähigkeit, Temperatur, Abfluss und pH-Wert gemessen und die δD- und δ18O‑Isotopenzusammensetzung durch Cavity-Ring-Down-Spektroskopie ermittelt. Die Untersuchung zeigt, dass es sich bei der Möhlin im Oberlauf um einen silikatisch geprägten Fluss handelt, während sie sich im Unterlauf an der Grenze von silikatisch bis karbonatisch bewegt. Die Geologie hat den stärksten Einfluss auf die Wasserchemie der Möhlin, wobei große Anteile am geologischen Fingerabdruck durch ihre Zuflüsse geprägt werden. Weitere Einflussfaktoren sind anthropogene Einleitungen, wasserbauliche Maßnahmen sowie der ehemalige Bergbau im Elsass und Schwarzwald. Insgesamt weist das Wasser der Möhlin in Bezug auf die untersuchten Parameter eine gute Wasserqualität auf.
High-resolution topographic variables accurately predict the distribution of rare plant species for conservation area selection in a narrow-endemism hotspot in New Caledonia
Authors: Lannuzel Guillaume , Balmot Joan , Dubos Nicolas , Thibault Martin , Fogliani Bruno 
Published: February 2021

AbstractSpecies distribution models (SDMs) represent a widely acknowledged tool to identify priority areas on the basis of occurrence data and environmental factors. However, high levels of topographical and climatic micro-variation are a hindrance to reliably modelling the distribution of narrow-endemic species when based on classic occurrence and climate datasets. Here, we used high-resolution environmental variables and occurrence data obtained from dedicated field studies to produce accurate SDMs at a local scale. We modelled the potential current distribution of 23 of the 25 rarest species from Mount Kaala, a hotspot of narrow-endemism in New Caledonia, using occurrence data from two recent sampling campaigns, and eight high-resolution (10 m and 30 m) environmental predictors in a Species Distribution Modelling framework. After a first sampling operation, we surveyed six additional areas containing, overall, 13 of the 20 species modelled at this stage, to validate our projections where the highest species richness levels were predicted. The ability of our method to define conservation areas was largely validated with an average 84% of predicted species found in the validation areas, and additional data collected enabling us to model three more species. We therefore identified the areas of highest conservation value for the whole of Mount Kaala. Our results support the ability of SDMs based on presence-only data such as MaxEnt to predict areas of high conservation value using fine-resolution environmental layers and field-collected occurrence data in the context of small and heterogeneous systems such as tropical islands.
DTX3 copy number increase in breast cancer: a study of associations to molecular subtype, proliferation and prognosis
Authors: Valla Marit , Opdahl Signe , Ytterhus Borgny , Bofin Anna Mary 
Published: February 2021

AbstractPurposeThe degree of cell proliferation is important for subclassification of breast cancers into prognostic and therapeutic groups. DTX3 has been identified as a driver of proliferation in luminal breast cancer. In this study, we describe DTX3 copy number in breast cancer primary tumours and corresponding axillary lymph node metastases, and studied associations with molecular subtype, proliferation and prognosis.MethodsUsing fluorescence in situ hybridization, we assessed DTX3 and chromosome 12 centromere (CEP12) copy number in 542 primary breast cancers and 117 lymph node metastases, from a well-described cohort of Norwegian breast cancer patients. Proliferation was expressed as mitotic counts and Ki67 score. Associations between DTX3 copy number and molecular subtype and proliferation were assessed using Pearson’sχ2test. We studied the effect of copy number increase on prognosis estimating cumulative incidence of breast cancer death and hazard ratios.ResultsMean DTX3 copy number ≥ 4 was found in 23 tumours (4%), and mean ≥ 5 in 9 tumours (1.7%). Copy number increase was found within all molecular subtypes except the 5 negative phenotype and the Luminal B (HER2 +) subtype. DTX3 copy number increase was not accompanied by an increase in CEP12. Point estimates showed that there were associations between DTX3 copy number increase and high proliferation and poor prognosis; however, precision depended on copy number cut-off.ConclusionsDTX3 copy number increase was present in a small proportion of breast cancer cases. There was an association between copy number increase and high tumour cell proliferation and poor prognosis.
Quantification of regurgitation in mitral valve prolapse with automated real time echocardiographic 3D proximal isovelocity surface area: multimodality consistency and role of eccentricity index
Authors: Spampinato Ricardo A. , Lindemann Frank , Jahnke Cosima , Paetsch Ingo , Fahr Florian , Sieg Franz , von Roeder Maximilian , Noack Thilo , Hilbert Sebastian , Löbe Susanne , Strotdrees Elfriede , Hindricks Gerhard , Borger Michael A. 
Published: February 2021

AbstractThree-dimensional transthoracic echocardiography (3D-TTE) provides a semi-automated proximal isovelocity surface area method (3D-PISA) to obtain quantitative parameters. Data assessing regurgitation severity in mitral valve prolapse (MVP) are scarce, so we assessed the 3D-PISA method compared with 2D-PISA and cardiovascular magnetic resonance (CMR) and the role of an eccentricity index. We evaluated the 3D-PISA method for assessing MR in 54 patients with MVP (57 ± 14 years; 42 men; 12 mild/mild-moderate; 12 moderate-severe; and 30 severe MR). Role of an asymmetric (i.e. eccentricity index ≥ 1.25) flow convergence region (FCR) and inter-modality consistency were then assessed. 3D-PISA derived regurgitant volume (RVol) showed a good correlation with 2D-PISA and CMR derived parameters (r = 0.86 and r = 0.81, respectively). The small mean differences with 2D-PISA derived RVol did not reach statistical significance in overall population (5.7 ± 23 ml, 95% CI − 0.6 to 12; p = 0.08) but differed in those with asymmetric 3D-FCR (n = 21; 2D-PISA: 72 ± 36 ml vs. 3D-PISA: 93 ± 47 ml; p = 0.001). RVol mean values were higher using PISA methods (CMR 57 ± 33 ml; 2D-PISA 73 ± 39 ml; and 3D-PISA 79 ± 45 ml) and an overestimation was observed when CMR was used as reference (2D-PISA vs. CMR: mean difference: 15.8 ml [95% CI 10–22, p < 0.001]; and 3D-PISA vs. CMR: 21.5 ml [95% CI 14–29, p < 0.001]). Intra- and inter-observer reliability was excellent (ICC 0.91–0.99), but with numerically lower coefficient of variation for 3D-PISA (8%–10% vs. 2D-PISA: 12%–16%). 3D-PISA method for assessing regurgitation in MVP may enable analogous evaluation compared to standard 2D-PISA, but with overestimation in case of asymmetric FCR or when CMR is used as reference method.
A mechanism for fire retardancy realized by a combination of biofillers and ammonium polyphosphate in various polymer systems
Authors: Matsumoto Koki , Tanaka Tatsuya , Sasada Masahiro , Sano Noriyuki , Masuyama Kenta 
Published: February 2021

AbstractThis study focused on realizing fire retardancy for polymer composites by using a cellulosic biofiller and ammonium polyphosphate (APP). The motivation of this study was based on revealing the mechanism of the synergetic effect of a cellulosic biofiller and APP and determining the parameters required for achieving a V-0 rating in UL94 standard regardless of the kind of polymer system used. As for the polymer matrix, polypropylene and polylactic acid were used. The flammability, burning behavior and thermal decomposition behavior of the composites were investigated through a burning test according to the UL-94 standard, cone calorimetric test and thermogravimetric analysis. As a result, the incorporation of a high amount of cellulose enabled a V-0 rating to be achieved with only a small amount of APP despite the variation of the optimum cellulose loading between the matrix polymers. Through analysis, the results indicated that APP decreased the dehydration temperature of cellulose. Furthermore, APP promoted the generation of enough water as a nonflammable gas and formed enough char until the degradation of the polymer matrix was complete. The conditions required to achieve the V-0 rating were suggested against composites incorporating APP and biofillers. Furthermore, the suggested conditions were validated by using polyoxymethylene as a highly flammable polymer.
Development of lignocellulosic fiber reinforced cement composite panels using semi-dry technology
Authors: Hasan K. M. Faridul , Horváth Péter György , Alpár Tibor 
Published: February 2021

AbstractThere is a growing interest in developing cement bonded lignocellulosic fiber (LF) composites with enhanced mechanical performances. This study assessed the possibility of developing composite panels with 12 mm thickness and around 1200 kg/m3 nominal densities from ordinary Portland cements (OPC) and mixed LFs from seven different woody plants found in Hungary. Once the mixed LFs were sieved and found fine (0–0.6 mm) and medium (0.6–0.8 mm) length fibers. The optimum ratio for LF, OPC, water glass (Na2SiO3), and cement stone was found to be 1:3.5:0.7:0.07. The semi-dry process, which is a comparatively cheaper and less labor intensive technology, was used for producing the composites. After 28 days of curing, the composite panels were characterized for mechanical, physical, thermal, and morphological properties. A scanning electron microscopy (SEM) test was conducted to observe the fiber orientation in the matrix before and after the bending test, which showed the clear presence of the fibers in the composites. The FTIR (Fourier transform infrared spectroscopy) was conducted to investigate the presence of chemical compounds of LF in the composite panels. Different physical (water absorption and thickness swelling) characteristics of the composite panels were investigated. Furthermore, mechanical properties (flexural properties and internal bonding strength) of the composite panels were also found to be satisfactory. The flexural modulus and internal bonding strengths of composite panel 2 is higher than other three boards, although the flexural strength is a little lower than composite panel 1. The thermogravimetric analysis and differential thermogravimetry also indicated better thermal stability of composite panels which could be used as potential insulation panel for buildings.
Graphic abstract
The Influence of Negative Feedback and Social Rank on Feelings of Shame and Guilt: A Vignette Study in 8- to 13-Year-Old Non-Clinical Children
Authors: Hendriks Eline , Muris Peter , Meesters Cor 
Published: February 2021

AbstractThis experimental study examined the role of negative feedback and social rank in the experience of self-conscious emotions, shame and guilt, in typically developing children aged 8 to 13 years. Participants were tested by means of a vignette paradigm in which feedback and social rank were systematically manipulated and levels of shame and guilt were assessed after listening to each of the vignettes. In addition, children completed a set of questionnaires for measuring individual differences in shame and guilt proneness, social comparison, submissive behavior, and external shame. The results showed that children presented with negative feedback reported higher ratings of shame and guilt than when presented with positive feedback, implying that the provision of negative feedback has a significant impact on children’s experience of self-conscious emotions. Social rank had less effect on children’s report of these self-conscious emotions. Furthermore, the individual difference variables of guilt proneness, and to a lesser extent shame proneness and submissive behavior, appeared to be positively related to self-conscious emotions as reported during the vignette task.
Compensation effect of winter snow on larch growth in Northeast China
Authors: Li Yuanqiao , Wu Xiuchen , Huang Yongmei , Li Xiaoyan , Shi Fangzhong , Zhao Shoudong , Yang Yuting , Tian Yuhong , Wang Pei , Zhang Shulei , Zhang Cicheng , Wang Yang , Xu Chongyang , Zhao Pengwu 
Published: February 2021

AbstractWinter snow plays a crucial role in regulating tree growth during the subsequent growing season in regions suffering seasonal or even annual drought stress, but the mechanisms of the potential compensation effect of winter snow on subsequent growing-season tree growth are not well understood. In this study, we establish tree-ring chronologies of six larch forest stands along a marked drought gradient across Northeast China. We identify the spatial pattern in the compensation effects of winter snow on subsequent growing-season tree radial growth and uncover a potentially enhanced compensation effect in drier climates. Our results indicate that in snow-rich sites, winter snow tends to exert a significantly positive effect on tree growth during the growing season, whereas this growth compensation effect is reduced in drier sites. More importantly, our findings identify a much higher compensation effect of winter snow on growing-season larch growth in drier years (24.4–48.0%) than in wetter years (6.1–8.1%) at snow-rich sites. Given the projected increase in both severity and duration of droughts in temperate regions, the potential compensation effect of winter snow could play a crucial role in mediating the adaptation ability of boreal/hemi-boreal forest ecosystems in response to a warmer and drier future climate in these regions.
Small invertebrates in bivalve-cultivated and unmodified habitats of nearshore ecosystems
Authors: Munsch Stuart H. , Barber Julie S. , Cordell Jeffery R. , Kiffney Peter M. , Sanderson Beth L. , Toft Jason D. 
Published: February 2021

AbstractMany nearshore ecosystems are modified by aquaculture, including bivalve culture to produce food and restore extirpated populations. Small invertebrates in nearshore ecosystems support fundamental ecological processes, but the effects of bivalve culture on invertebrates are incompletely understood. Here, we compared invertebrate assemblages from multiple studies of bivalve-cultivated and unmodified nearshore habitats along the US west coast. In general, unmodified eelgrass and nearby off-bottom culture habitats with eelgrass present were inhabited by a greater abundance, richness, and diversity of epibenthic invertebrates than bottom culture and bare (mud, sand) habitats that both lacked eelgrass. Findings of individual studies suggested: minor differences in epibenthic invertebrate assemblages associated with various aquaculture practices; restoring native oysters to mudflats did not detectably alter epibenthic invertebrate abundances; epibenthic invertebrates were more abundant on shell hash introduced to mudflats than unmodified mudflats; and benthic invertebrates were less abundant, rich, and diverse in habitats cultured on bottom by Manila clams. Considering the range of these patterns, there appears to be potential for coastal communities to restore extirpated bivalve populations or develop bivalve culture practices that meet objectives to grow food while maintaining nearshore ecosystems’ fundamental processes supported by robust invertebrate assemblages.
Effects of temperature and plant diversity on orthopterans and leafhoppers in calcareous dry grasslands
Authors: Geppert Costanza , La Bella Greta , Boscutti Francesco , Sanna Francesco , Marangoni Federico , Marini Lorenzo 
Published: February 2021

Abstract
In mountains, current land-use changes are altering plant communities of semi-natural grasslands with potential cascading effects on associated herbivores. Besides vegetation changes, temperature is also a key driver of insect diversity, and in the European Alps is predicted to increase by 0.25 °C per decade. Understanding herbivore responses to temperature and plant composition changes in mountain environments is of increasing importance. Our study aims at investigating the response to temperature and plant diversity and composition of two key herbivore groups (orthopterans and leafhoppers) belonging to contrasting feeding guilds (chewers vs. sap-feeders). We hypothesized that orthopteran diversity would be driven by temperature while leafhoppers by plant community composition. We selected 15 dry calcareous grasslands ranging from 100 to 1330 m a.s.l. along two independent gradients of plant diversity and temperature. We sampled orthopteran and leafhopper species richness and abundance by sweep-netting. Consistent with their low feeding specialisation, orthopteran species richness and community composition were only driven by temperature. By contrast, leafhopper species richness was not affected by temperature nor by plant diversity but leafhopper community composition was strongly influenced by plant species composition. This response can be explained by the higher host feeding specialisation of many leafhopper species. Species rarity and mobility did not change the response of the diversity of both groups, but orthopteran abundance increased with temperature only for highly mobile species. Altogether, our results suggest that future responses of grassland herbivores to vegetation changes and temperature warming are highly variable and depend on the feeding strategy and specialisation of the focal herbivore group.

Implications for insect conservation
Leafhoppers emerged to be particularly sensitive to potential management or climate-induced change in vegetation composition, while orthopterans are expected to respond directly to temperature warming due to their relaxed association with plant community diversity and composition.
Maintenance optimization for a multi-unit system with digital twin simulation
Authors: Savolainen Jyrki , Urbani Michele 
Published: February 2021

AbstractOptimization of operations and maintenance (O&M) in the industry is a topic that has been largely studied in the literature. Many authors focused on reliability-based approaches to optimize O&M, but little attention has been given to study the influence of macroeconomic variables on the long-term maintenance policy. This work aims to optimize time-based maintenance (TBM) policy in the mining industry. The mine environment is reproduced employing a virtual model that resembles a digital twin (DT) of the system. The effect of maintenance decisions is replicated by a discrete event simulation (DES), whereas a model of the financial operability of the mine is realized through System Dynamics (SD). The simultaneous use of DES and the SD allows us to reproduce the environment with high-fidelity and to minimize the cost of O&M. The selected illustrative case example demonstrates that the proposed approach is feasible. The issues of using high dimensional simulation data from DT-models in managerial decision making is identified and discussed.
The primacy of the noematic. On the methodological relevance of art for phenomenology
Authors: Figal Guenter 
Published: February 2021

AbstractAs Husserl already noticed, artworks themselves have a phenomenological character. This means, however, that to experience artworks as phenomena no “epoché” and no “phenomenological reduction” is necessary. The leading question of my essay is whether, and possibly how, this observation can be methodologically generalized for understanding phenomena. I discuss if, and possibly how, a phenomenological reflection on art allows and even demands a general conception of phenomenology that nevertheless does not confuse artworks with phenomena in general. My intention is to show that and how phenomenality can be clarified with reference to its spatial character. Accordingly, works of architecture that are artworks will play a decisive role in my argument.
Zooming into chaos as a pathway for the creation of a fast, light and reliable cryptosystem
Authors: Machicao Jeaneth , Bruno Odemir M. , Baptista Murilo S. 
Published: February 2021

AbstractMotivated by today’s huge volume of data that needs to be handled in secrecy, there is a wish to develop not only fast and light but also reliably secure cryptosystems. Chaos allows for the creation of pseudo-random numbers (PRNs) by low-dimensional transformations that need to be applied only a small number of times. These two properties may translate into a chaos-based cryptosystem that is both fast (short running time) and light (little computational effort). What we propose here is an approach to generate PRNs—and consequently digital secret keys—that can serve as a seed for an enhanced chaos-based cryptosystem. We use low-dimensional chaotic maps to quickly generate PRNs that have little correlation, and then, we quickly (“fast”) enhance secrecy by several orders (“reliability”) with very little computational cost (“light”) by simply looking at the less significant digits of the initial chaotic trajectory. This paper demonstrates this idea with rigor, by showing that a transformation applied a small number of times to chaotic trajectories significantly increases its entropy and Lyapunov exponents, as a consequence of the smoothing out of the probability density towards a uniform distribution.