bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potrauminio streso sutrikimo simptomų pokyčiai pasinaudojus į traumą orientuotos kognityvinės elgesio terapijos principais grįsta internetu teikiama intervencija: bandomojo tyrimo rezultatai
Authors: Geležėlytė Odeta , Guogaitė Greta , Nomeikaitė Augustė , Bisson Jonathan , Lewis Catrin , Jackūnaitė Greta , Kasperavičiūtė Emilija , Kazlauskas Evaldas 
Published: February 2025

Posttraumatic stress disorder (PTSD) is a common mental disorder. However, only a part of people with PTSD receive the necessary treatment. Digital interventions could provide a more accessible alternative to the traditional face-to-face therapies. ‘Spring’ is an internet-based guided self-help intervention developed at Cardiff University (UK). It is based on the principles of trauma-focused cognitive behavioural therapy and has been developed with the objective to reduce mild to moderate PTSD symptoms associated with a single traumatic experience. The aim of this pilot study was to assess changes in the mental health indicators of individuals with PTSD after using the Lithuanian version of ‘Spring’. Data from seven women with PTSD who used the ‘Spring’ intervention were analysed. The mean age of the participants was 41 years (SD = 15). The results showed a significant reduction in posttraumatic stress, depression and anxiety symptoms, and an increase in psychological well-being after the intervention. The reduction in PTSD symptoms was statistically reliable for all participants, and six of the seven participants showed changes corresponding with a loss of their probable PTSD diagnosis after undergoing ‘Spring’. Overall satisfaction with the intervention was high. The early results from this pilot study of the Lithuanian version of ‘Spring’ guided internet-based intervention show that it can be a promising PTSD treatment method. More research is still needed to evaluate the efficaciousness of ‘Spring’ in larger samples.
IMPROVING ACCESS TO HIGH-TECH MEDICAL CARE FOR RESIDENTS OF SMALL TOWNS IN THE KEMEROVO REGION THROUGH THE DEVELOPMENT OF THE HUMAN RESOURCE POTENTIAL OF MEDICAL INSTITUTIONS
Authors: Artamonova Galina V. , Drushlyak Irina A. , Popsuiko Artem N. , Samus Irina V. , Makarov Sergey A. , Barbarash Olga L. 
Published: February 2025

HighlightsThe article shows the positive impact of measures aimed at the improvement of human resources in primary care on the availability of high-tech medical care for patients with circulatory diseases for the population of small territories, and analyzes the effectiveness of the conducted educational and organizational activities for medical personnel. The findings allowed us to identify targets for improvement of knowledge among primary health care workers, which is a basic value in the development of staff potential of employees at the municipal level. Aim. To assess the effectiveness of measures of improving human resources in primary health care, aimed at enhancement of the quality of selection and availability of HTMC for patients with diseases of the circulatory system. Methods. The study was carried by employees of the Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases” (hereinafter referred to as the Research Institute of Cardiovascular Diseases) at the State Budgetary Healthcare Institution “Guryevsk District Hospital”. The subject of the study is the level of training of primary care medical workers in terms of diagnostics, treatment and routing of patients with diseases of the circulatory system. The methods used in the present study included analytical, statistical, sociological. The object of the study – physicians and paramedics of medical organization. Time period of the study: 01.07.2023–29.12.2023.Results. Increase in the level of knowledge among primary health care workers on topical issues of identification and selection of patients for open surgery for cardiovascular diseases, as well as the implementation of organizational measures aimed at the improvement of working conditions, affect the availability of specialized care, including HTMC. In 2023 compared to 2022, there was a 37% (p = 0,001) increase (p = 0,001) in the number of telemedicine consultations made to select patients for HTМС, a 65% (p = 0.001) increase (p = 0,001) in the number of diagnostic CAGs, and a 69% (p = 0,001) increase (p = 0,001) in the number of planned HTМС technologies performed.Conclusion. The analysis of performance indicators in the study period indicates the impact of educational and organizational activities, including telemedicine consultations, on improving the level of knowledge among medical workers, which is an important condition for the improvement of human resource potential and contributes to improving the accessibility of HTMC in diseases of the circulatory system to the population of small territories. The presented experience can be replicated for at any medical organization.
SUDDEN CARDIAC DEATH: EPIDEMIOLOGY, ETIOLOGY, PATHOGENESIS AND RISK FACTORS
Authors: Ivanova Anastasia A. , Nesterec Alina M. , Maksimov Vladimir N. 
Published: February 2025

HighlightsThe review presents modern available data on the epidemiology, etiology, pathogenesis, and risk factors for sudden cardiac death. AbstractRussia remains one of the leading countries regarding high mortality from cardiovascular diseases. Sudden cardiac death is an urgent and significant issue in modern medicine, it is associated with a high prevalence of cardiovascular diseases and a large number of sudden cardiac deaths in the overall mortality rate from cardiovascular pathologies. Middle-aged (working-age) men are predominately at risk, thus making sudden cardiac death a socio-economic issue as well. At the same time, the issue of detecting predisposition to sudden cardiac death remains unresolved and urgent, since a large number of people who passed away due to sudden cardiac death were not diagnosed with cardiovascular disease. The review is devoted to modern research and current ideas about the epidemiology, etiology, pathogenesis and risk factors for sudden cardiac death.
PERSPECTIVES ON USING INHALED NITRIC OXIDE AND ITS ORGAN PROTECTION FEATURES IN CARDIOVASCULAR SURGERIES WITH CARDIOPULMONARY BYPASS: A SYSTEMATIC REVIEW
Authors: Mikhailova Alyona A. , Ivkin Artem A. , Grigoriev Evgeny V. 
Published: February 2025

Highlights Cardiovascular surgery with cardiopulmonary bypass for congenital heart defects in children is associated with the issue of organ protection that impacts the outcome and subsequent rehabilitation process. The literature review highlights the need to improve cardiopulmonary bypass-associated adverse effects in cardiovascular interventions in different patient populations. Article Pathological effects of cardiopulmonary bypass (CPB), which is necessary for most surgeries in children and adults with congenital heart defects, remains an unresolved issue. The functional immaturity of the circulatory system and endogenous mechanisms of organ protection in children necessitates intraoperative protection of the organs affected by CPB. The severity of the effects of extracorporeal circuits can lead to an increase in comorbidity and mortality in patients who have undergone CPB. The relevance of the study lies in the fact that most organ protection strategies adopted in adults are inapplicable in children. The search for Russian and English publications (up to 7 years old) was performed using the following databases: Web of Science, PubMed, E-library. The keywords for the search were: nitric oxide, cardiopulmonary bypass, congenital heart defects, organ protection. Literature analysis results revealed the potential for further research on the inhaled nitric oxide for organ protection during cardiac surgery, and the feasibility of its perioperative administration. The nitric oxide is a promising method of organ protection in cardiac surgery with CPB. Moreover, scientific data highlight the importance of the organ protection during CPB in order to ensure successful outcome of the intervention. However, further research on inhaled nitric oxide effects is necessary.
HYPERTROPHIC CARDIOMYOPATHY IN TEENAGER WITH LEOPARD SYNDROME (CLINICAL CASE)
Authors: Kulavskaya Marianna V. , Shabaev Ilmir F. , Rumyantseva Alexandra A. , Evtushenko Aleksey V. , Mamchur Irina N. , Bogachev-Prokophiev Alexander V. 
Published: February 2025

HighlightsThis review describes a rare clinical case of hypertrophic cardiomyopathy in a teenager with LEOPARD syndrome. AbstractHypertrophic cardiomyopathy (HCM) is a genetically determined cardiac disease which can be caused by nearly 1500 genetic mutations, encoding proteins of the cardiac sarcomere and some non-sacromeric proteins. There is a number of hereditary metabolic disorders and diseases which can imitate phenotype and clinical picture of HCM. Abnormalities with systemic symptoms are usually identified as a syndrome, including hypertrophic myocardium signs. Such abnormalities are regarded to the RASopathies, a group of phenotypically similar genetic syndromes. Nowadays RASopathies include 1-type neurofibromatosis, Noonan syndrome, LEOPARD syndrome, Costello syndrome, Legius syndrome, cardiofaciocutaneous syndrome, and capillary malformation-arteriovenous malformation syndrome.
A CLINICAL CASE OF THE “STONE HEART” SYNDROME IN A PREMATURE BABY WITH RADICAL CORRECTION OF A CONGENITAL HEART DEFECT: VENTRICULAR SEPTAL DEFECT AND ATRIAL SEPTAL DEFECT
Authors: Zinchuk Polina V. , Khalivopulo Ivan K. , Ivkin Artem A. , Borisenko Dmitry V. , Lyapin Anton A. , Bogdanov Lev A. 
Published: February 2025

HighlightsThe article aims to expand the understanding of septal defects in children with congenital heart defects, emphasizing their frequency and variety of clinical manifestations, and to describe radical corrections of hearts defects, which, despite their routine nature, can be accompanied by severe complications. AbstractSeptal defects in children with congenital heart disease (CHD) occur frequently: atrial and interventricular septal defects are quite common, either in isolation or as a part of other complex heart defects. In many cardiac surgical centers, surgical correction of septal defects is considered a “routine” operation; such patients usually do not have complications before, during, or after surgical intervention. Despite the seemingly commonplace nature of the procedure, there are some severe complications such as “stone heart” syndrome. Stone heart syndrome or ischemic myocardial contracture is a condition caused by impaired blood supply to the myocardium, resulting in impairment of energy metabolism in cardiomyocytes and the development of ischemic contracture. The article presents a clinical case of a child undergoing a radical correction of CHD complicated by fatal ischemic myocardial contracture.
Bots Election: Unveiling the complex network of social botnets
Authors: Bigdeli Parsa , Moradi Parham , Jafari Reza 
Published: February 2025

Abstract

With the exponential growth of bots surpassing the near saturation of genuine users, a large socio-bot network has emerged. Botnets have evolved to exhibit significant social properties through their interactions with humans. This structure has empowered bots with capabilities that cannot be observed locally. Hence, as a novel paradigm, this study advocates examining bots as a complex network akin to human social networks. As an exemplar, in our study on Farsi Twitter users during Iran’s 2021 presidential election, 71.2% of the users were identified as bots. By isolating the botnet, we analyzed the distinctions between bots and genuine users within complex networks, revealing a more robust, efficient, and controllable structure for information dissemination. To explore how following and retweeting actions influence each other, we classified bots based on their actions and examined the roles of each classification, the differences between the functional and structural core, observing while the functional-core bots facilitate the botnets’ percolation, the non-common bots alter the mechanisms of networks. Additionally, we observed how the activity of bots is limited within both the functional core and the entire system. Politically, our findings indicated that despite the candidates’ use of bot accounts, political figures did not play a crucial role in controlling the botnet. We further explored the interactions between opposing political preferences and the role of bots with no preferences in bridging political divides and forming echo chambers.
Navigating uncertainties in RT-qPCR and plaque assay for infectivity assessment of norovirus
Authors: Mirmahdi Razieh Sadat , Dicker Samantha L. , Garba Yusuf Nuradeen , Montazeri Naim 
Published: February 2025

Abstract

Human norovirus (hNoV) is the primary cause of gastroenteritis globally. Due to the lack of a reliable cultivation system, RT-qPCR is a gold standard technique for detection and quantification of hNoV. However, the inability of PCR to differentiate between infectious from non-infectious particles remains a significant limitation. This study aims to address this limitation by exploring the relationship between culture-based (plaque assay and TCID50) and non-culture based (RT-qPCR) methods for hNoV quantification, using Tulane virus as a surrogate. The Ultracentrifuge-purified Tulane virus at 6.7 log10 PFU/ml or 5.8 log10 TCID50/ml in Tris-EDTA buffer (pH 7.2), was serially diluted and subjected to RNA extraction, with or without RNase pre-treatment, followed by quantification using RT-qPCR. Further physical characterization of the stock was performed with dynamic light scattering and transmission electron microscopy. A strong correlation (Pearson's Correlation Coefficient of 0.99) was observed between log10 genome copies (GC) and log10 plaque forming units (PFU) per PCR reaction for both RNase-treated and untreated samples. Beta distribution analysis indicated a similar median GC:PFU ratio of ca. 3.7 log10 for both RNase-treated and untreated samples. The high GC:PFU ratio may indicate the sensitive nature of RT-qPCR. The outcomes of this study will contribute to the more accurate estimation of infectious norovirus particles in food and environmental matrices.
Efficacy of Fully Covered Self-Expanding Metal Stents Removal versus Stent- in-Stent Techniques in Recurrent Malignant Distal Biliary Obstruction
Authors: Lee See Young , Jang Sung Ill , Kim Eui Joo , Lee Dong Ki , Seong Yeseul , Jo Jung Hyun , Jung Chan Min , Lee Hyun Seok , Cho In Rae , Paik Woo Hyun , Ryu Ji Kon , Lee Sang Hyub , Cho Jae Hee 
Published: February 2025

Abstract

Fully covered self-expandable metal stents (FCSEMSs) are widely used in managing malignant distal biliary obstruction (MDBO). However, recurrent biliary obstruction (RBO) has become a significant challenge due to improved patient survival with advanced chemotherapy. This multicenter retrospective cohort study evaluated revision techniques for FCSEMS dysfunction in 159 patients with MDBO initially treated with FCSEMSs. Patients were categorized into four groups based on the revision method: stent exchange with self-expandable metal stents (SEMS, n=53) or plastic stents (n=23), and stent-in-stent placement with SEMS (n=51) or plastic stents (n=32). All procedures achieved 100% technical and clinical success. The primary time to recurrent biliary obstruction (TRBO) showed no significant difference among the groups (mean: 142 days, 95% confidence interval [CI]: 121–164 days). However, secondary TRBO differed significantly (p=0.014): 161 days (SEMS, stent exchange), 53 days (plastic stent, stent exchange), 104 days (SEMS, stent-in-stent), and 67 days (plastic stent, stent-in-stent). Multivariate analysis revealed that stent-in-stent placement with SEMS increased the risk of RBO compared to SEMS stent exchange (hazard ratio [HR]: 6.84, 95% CI: 1.89–22.55, p=0.003). Additionally, revision within 180 days was associated with a higher risk of RBO (HR: 1.77, 95% CI: 1.10–2.86, p=0.019). Overall survival was comparable across all groups. These findings suggest that SEMS stent exchange after FCSEMS removal is an effective revision method for RBO in MDBO, providing improved secondary stent patency without increasing adverse events or affecting overall survival.
Metabolic Parameters on Baseline and Early [18F]FDG PET/CT as a Predictive Biomarker for Resistance to BRAF/MEK Inhibition in Advanced Cutaneous BRAFV600-mutated Melanoma
Authors: Hiel Bernies van der , Veen Berlinda J. de Wit - van der , Eertwegh Alfons J.M. van den , Vogel Wouter V. , Stokkel Marcel P.M. , Lopez-Yurda Marta , Boellaard Ronald , Kapiteijn Ellen W. , Hospers Geke A.P. , Aarts Maureen J.B. , de Vos Filip Y.F.L. , Boers-Sonderen Marye J. , Veldt Astrid A.M. van der , de Groot Jan Willem B. , Haanen John B.A.G. 
Published: February 2025

Abstract

Background: [18F]FDG PET/CT plays a crucial role in evaluating cancer patients and assessing treatment response, including in BRAF-mutated melanoma. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) have emerged as promising alternatives to standardized uptake value (SUV)-based measures for tumor assessment. This study evaluates the predictive value of SUVpeak, MTV, and TLG in predicting progression-free survival (PFS) in advanced BRAF-mutated melanoma treated with BRAF/MEK inhibitors.
Results: Seventy-five patients with metastatic melanoma were enrolled in a multi-center trial and treated with vemurafenib/cobimetinib. [18F]FDG-PET/CT scans were performed at baseline, week-2, and week-7. Imaging analysis included SUVpeak, MTV, and TLG of summed metastases, as well as percentage changes over time (∆). Baseline median PET-parameters were SUVpeak 12.59 (range 3.13-50.59), MTV 159mL (range 0-1897 mL), and TLG 1013 (range 1-13162). MTV had the highest predictive performance for risk of progression (AUCT=6 months=0.714). Patients with TLG below the median had significantly prolonged PFS (15.4 vs. 8.5 months, P=0.024). MTV above optimal cutoff (45.3 mL) was associated with an increased risk of progression/death, even after adjusting for LDH, ECOG status, and metastatic sites (HR=2.97, 95% CI 1.17-7.52, P=0.022).
At week-7, ∆SUVpeak% was predictive (median ∆SUVpeak%: 64); PFS was 5.0 months (95% CI: 4.3-NA) for patients below the median versus 14.7 months (95% CI: 9.2-20.2) for those above or with non-quantifiable scans (P=0.0002). Median ∆MTV was 95.5% at week-2 and 97.6% at week-7, with significant PFS differences at both time points (week-2: P=0.020, week-7: P<0.001). TLG mirrored MTV. Patients with MTV increases at week-7 after an initial response at week-2 had a median PFS of 5.3 vs. 12.6 months for those with stable or declining MTV (P=0.0023).
Conclusion: This study supports the use of MTV and TLG as robust predictive markers for PFS in advanced melanoma treated with BRAF/MEK-inhibitors. Monitoring early PET parameters changes can provide valuable insights into therapeutic response and disease progression.
Trial Registration
Clinicaltrials.gov identifier: NCT02414750. Registered 10 April 2015, retrospectively registered.
The Role of Geriatric Nutritional Risk Index in Predicting Adverse Outcomes of Bloodstream Infections: A Retrospective Study
Authors: Li Xin-Lou , Yu Zheng-Hao , Zhou Wu-Hong , Bai Yan-Ling , Liu Bo-Wei , Zhang Xiao-Ming , Li Huan , Li Jia-Xi , Ma Cheng-Xue , Du Ming-Mei , Liu Yun-Xi , Liu Meng-Lin , Yao Hong-Wu 
Published: February 2025

Abstract

Background: Nutritional deficiencies have been associated with the high prevalence of healthcare-associated infections (HAIs), which is particularly severe in elderly patients. The adverse effects of bloodstream infections (BSIs) in elderly patients are severe when it occurs. The Geriatric Nutritional Risk Index (GNRI), specifically designed for the elderly, itsprediction value of adverse outcomes of BSIs patients is unclear.
Methods: We conducted a two-year retrospective study in a large Chinese tertiary hospital, collecting surveillance data on patients with bloodstream infections (BSI). We utilized descriptive analysis to delineate the demographic and clinical characteristics of BSI patients across different GNRI levels. The relationship between GNRI and mortality in BSI patients was investigated using logistic regression and restricted cubic spline (RCS) analysis.
Results: From 2020-2021, a total of 464 patients with BSI were identified. Among them, 203 (43.8%) were no risk, 70 (15.1%) at low risk, 118 (25.4%) at moderate risk and 73 (15.7%) at major risk for nutrition-related complications based on the GNRI classification of. Patients whose GNRI at higher risk had longer length of hospital stay (P< 0.001) and higher mortality (P< 0.001). After adjusting for other covariates by multivariate logistic regression analysis, GNRI at major risk (GNRI< 82) [odds ratio (OR): 3.16; 95% confidence interval (CI): 1.52-6.58; P= 0.002] and GNRI at moderate risk (82 to <92) (OR: 1.91; 95% CI: 1.00-3.62; P= 0.049) were associated with increased risk for mortality in patients with BSI, while GNRI score (per unit increase) had a protective effect (OR: 0.96; 95% CI: 0.94-0.98; P= 0.001). Furthermore, the RCS analysis shown that the risk of mortality decreased as GNRI scores increased and gradually became stable at GNRI scores above 96-98.
Conclusions: There is an association between GNRI and mortality in patients with BSI. For those patients with a lower GNRI, clinicians need to provide more timely and rational nutritional intervention to reduce mortality.
Multi-index retrospective analysis of eosinophilic pleural effusion
Authors: Zhang Hui , Yuan Xu , Huang Ming , Fang Benli , Li Guo , Zhang Hongbo 
Published: February 2025

Abstract

Background:Eosinophilic pleural fluid is a unique type of pleural fluid, the causes of which need to be further studied. In this study, a number of test indicators were collected to understand the characteristics of eosinophilic pleural effusion to better analyze eosinophilic pleural effusion and provide useful information for clinical practice.
Methods: A retrospective analysis was performed by examining the medical records of 2769 patients with pleural fluid (PE) from September 2013 to January 2024. Blood routine, blood biochemistry, coagulation, pleural fluid routine, and pleural fluid biochemistry data of these patients were collected and analyzed. At the same time, 9 categories of etiologies of eosinophilic pleural effusion were classified, and their characteristics were analyzed.
Results: When 2769 cases of pleural effusion were examined and categorized, 461 cases ofeosinophilic pleural effusion (EPE) were identified. Among these EPE cases, 213 were associated with tumors, with lung cancer constituting 63.85% of these tumors, thus emerging as the primary cause of EPE. Furthermore, among the EPE patients, indicators such as D-D, TT, ALP, TBIL, GGT, GLU, LDH, PB-WBC, PB-LYM, PB-PLT, PF-WBC, PF-NEU, PF-MON, ALT, and AST did not significantly differ (p value>0.05), whereas other indicators did. Within the EPE group, the parasitic subgroup had the highest median levels of PB-EOS% and PF-EOS% across the nine etiological categories. When comparing EPE with non-EPE (n-EPE), in addition to FIB, UA, PF-RBC, ADA, and ALT, which were not significantly different, theother indicators were significantly different. In the correlation analysis, 11 sets of data within the EPE group had correlation coefficients with absolute values greater than 0.6. By applying an 8% threshold for PB-EOS%, the 461 cases of EPE were divided into two groups, revealing significant differences in Age, D-D, TP, PF-TP, UA, ALB, PF-ALB, PF-LDH, PB-WBC, PB-NEU, PB-EOS%, PB-RBC, PB-HCT, PF-WBC, PF-EOS%, PF-LYM, and ADA.
Conclusions: Lung cancer is the main cause of eosinophilic pleural effusion, but parasitic infection is the most prominent factor influencing the percentage of eosinophils in the pleural fluid (PF-EOS%). The theory of eosinophilic pleural effusion needs to be further refined and enriched to improve clinical diagnosis and treatment.