bluuebunny/crossref_metadata_2025_split huggingface dataset:
A missense mutation in the FZD7 gene is associated with dilution of the red areas of the coat in Montbéliarde cattle
Authors: Floriot S. , Duchesne A. , Grohs C. , Hozé C. , Deloche M.C. , Fayolle G. , Vilotte J.L. , Boichard D. , Fritz S. , Boussaha M. 
Published: March 2021

SummaryRecently, a new genetically autosomal recessive color phenotype emerged in the red pied bovine Montbéliarde breed. It is characterized by a dilution of the red areas of the coat and was denominated ‘milca’. A genome‐wide homozygosity scan of 106 cases followed by haplotype analysis revealed a candidate region within BTA2 between positions 89.95 and 91.63 Mb. Analysis of whole‐genome sequence data generated from milca animals identified a strong candidate variant within the coding region of the Frizzled‐7 gene (FZD7). This gene encodes for a G‐protein coupled receptor for Wnt signaling proteins. The variant induces a glycine to alanine substitution in the second extracellular loop, p.(Gly414Ala). Cross‐species amino acid alignments revealed that this glycine is conserved among orthologs and most paralogs, suggesting that it plays an important role in FZD function. In addition, genotyping data revealed that the mutant allele is restricted to the Montbéliarde breed, at a 3.7% frequency. All homozygous cows for the mutant allele exhibited the milca phenotype whereas all heterozygotes had no coat color defects. In conclusion, this study strongly suggests that, in cattle, a mutation of FZD7 alone is sufficient to cause a coat color phenotype without any strong other adverse effect.
Adapting dialectical behavior therapy in Mandarin‐speaking Chinese patients with borderline personality disorder: An open pilot trial in Taiwan
Authors: Chang Ting‐Hsin , Liu Shen‐Ing , Korslund Kathryn , Lin Chen‐Ju , Lin Ying , Huang Hui‐Chun , Chen Shu‐Chin , Chang Yi‐Hung , Sun Fang‐Ju , Wu Shu‐I 
Published: March 2021

AbstractIntroductionDialectical behavior therapy (DBT) is the most commonly used treatment for patients suffering from borderline personality disorder (BPD). However, data on its applications in Asian countries remain lacking. This pilot study aims to evaluate the feasibility and effectiveness of applying Mandarin‐translated DBT among suicidal Chinese patients with BPD in Taiwan.MethodsAn open‐label trial design was implemented for the 1‐year standard DBT model. Patients from a psychiatric outpatient department in a general hospital in Taiwan with a history of ≥2 episodes of suicidal behavior within the previous year and who scored >40 on the Borderline Symptom List were invited to participate in this trial. Outcomes of suicidal behaviors, severity of BPD and depression symptoms, suicidal ideation, hopelessness, and quality of life were assessed at the beginning of the treatment and every 3 months until 12 months.ResultsEighteen patients participated, three of whom (16.7%) dropped out. Significant improvements were found in the frequency and severity of suicidal behaviors and ideations, depressive symptoms, and BPD symptoms beginning as early as the third month after initiating DBT.DiscussionThis pilot study found that DBT may be an effective and feasible intervention for Mandarin‐speaking individuals with a recent history of suicidal behaviors with BPD. Future randomized controlled trials with comparison groups are needed to further determine the efficacy of DBT on this population.
Cox regression model under dependent truncation
Authors: Rennert Lior , Xie Sharon X. 
Published: March 2021

AbstractTruncation is a statistical phenomenon that occurs in many time‐to‐event studies. For example, autopsy‐confirmed studies of neurodegenerative diseases are subject to an inherent left and right truncation, also known as double truncation. When the goal is to study the effect of risk factors on survival, the standard Cox regression model cannot be used when the survival time is subject to truncation. Existing methods that adjust for both left and right truncation in the Cox regression model require independence between the survival times and truncation times, which may not be a reasonable assumption in practice. We propose an expectation‐maximization algorithm to relax the independence assumption in the Cox regression model under left, right, or double truncation to an assumption of conditional independence on the observed covariates. The resulting regression coefficient estimators are consistent and asymptotically normal. We demonstrate through extensive simulations that the proposed estimator has little bias and has a similar or lower mean‐squared error compared to existing estimators. We implement our approach to assess the effect of occupation on survival in subjects with autopsy‐confirmed Alzheimer's disease.
Paediatric chronic myeloid leukaemia presenting in de novo or secondary blast phase ‐ a comparison of clinical and genetic characteristics
Authors: Sembill Stephanie , Göhring Gudrun , Schirmer Elke , Lutterloh Friederike , Suttorp Meinolf , Metzler Markus , Karow Axel 
Published: March 2021

SummaryAdditional data on blast phase (BP) chronic myeloid leukaemia (CML) in children and adolescents is essential for improving diagnostic and therapeutic approaches of this rare but serious condition. Here, we describe distinct clinical and genetic characteristics of 18 paediatric patients with de novo (n = 10) and secondary (n = 8) BP CML enrolled in the CML‐PAED‐II trial and registry. Our findings suggest that paediatric patients exhibit a diverse cytogenetic profile compared to adults with BP CML. In addition, patients with de novo BP CML in this cohort presented at a younger age, whereas patients with secondary BP CML more often harboured complex karyotypes.
Understanding host utilization by mosquitoes: determinants, challenges and future directions
Authors: Yan Jiayue , Gangoso Laura , Ruiz Santiago , Soriguer Ramón , Figuerola Jordi , Martínez‐de la Puente Josué 
Published: March 2021

ABSTRACTMosquito host utilization is a key factor in the transmission of vector‐borne pathogens given that it greatly influences host–vector contact rates. Blood‐feeding patterns of mosquitoes are not random, as some mosquitoes feed on particular species and/or individuals more than expected by chance. Mosquitoes use a number of cues including visual, olfactory, acoustic, and thermal stimuli emitted by vertebrate hosts to locate and identify their blood meal sources. Thus, differences in the quality/intensity of the released cues may drive host selection by mosquitoes at both inter‐ and intra‐specific levels. Such patterns of host selection by mosquitoes in space and time can be structured by factors related to mosquitoes (e.g. innate host preference, behavioural plasticity), to hosts (e.g. emission of host‐seeking cues, host availability) or to both (e.g. pathogen infection). In this study, we review current evidence, from phenomena to mechanisms, of how these factors influence host utilization by mosquitoes. We also review the methodologies commonly used in this research field and identify the major challenges for future studies. To bridge the knowledge gaps, we propose improvements to strengthen traditional approaches and the use of a functional trait‐based approach to infer mosquito host utilization in natural communities.
Safety and pharmacokinetics of milademetan, a MDM2 inhibitor, in Japanese patients with solid tumors: A phase I study
Authors: Takahashi Shunji , Fujiwara Yutaka , Nakano Kenji , Shimizu Toshio , Tomomatsu Junichi , Koyama Takafumi , Ogura Mariko , Tachibana Masaya , Kakurai Yasuyuki , Yamashita Tomonari , Sakajiri Sakura , Yamamoto Noboru 
Published: March 2021

AbstractMilademetan (DS‐3032, RAIN‐32) is an orally available mouse double minute 2 (MDM2) antagonist with potential antineoplastic activity owing to increase in p53 activity through interruption of the MDM2‐p53 interaction. This phase I, dose‐escalating study assessed the safety, tolerability, efficacy, and pharmacokinetics of milademetan in 18 Japanese patients with solid tumors who relapsed after or were refractory to standard therapy. Patients aged ≥ 20 years received oral milademetan once daily (60 mg, n = 3; 90 mg, n = 11; or 120 mg, n = 4) on days 1 to 21 in a 28‐day cycle. Dose‐limiting toxicities, safety, tolerability, maximum tolerated dose, pharmacokinetics, and recommended dose for phase II were determined. The most frequent treatment‐emergent adverse events included nausea (72.2%), decreased appetite (61.1%), platelet count decreased (61.1%), white blood cell count decreased (50.0%), fatigue (50.0%), and anemia (50.0%). Dose‐limiting toxicities (three events of platelet count decreased and one nausea) were observed in the 120‐mg cohort. The plasma concentrations of milademetan increased in a dose‐dependent manner. Stable disease was observed in seven out of 16 patients (43.8%). Milademetan was well tolerated and showed modest antitumor activity in Japanese patients with solid tumors. The recommended dose for phase II was considered to be 90 mg in the once‐daily 21/28‐day schedule. Future studies would be needed to further evaluate the potential safety, tolerability, and clinical activity of milademetan in patients with solid tumors and lymphomas. The trial was registered with Clinicaltrials.jp: JapicCTI‐142693.
OTUB1 facilitates bladder cancer progression by stabilizing ATF6 in response to endoplasmic reticulum stress
Authors: Zhang Hui‐Hui , Li Chao , Ren Jian‐Wei , Liu Lian , Du Xue‐Hua , Gao Jie , Liu Tao , Li Shang‐Ze 
Published: March 2021

AbstractThe unfolded protein response (UPR) plays an important role in carcinogenesis, but the functional role and mechanism of UPR‐associated bladder carcinogenesis remain to be characterized. Upon UPR activation, ATF6α is activated to upregulate the transcription of UPR target genes. Although the mechanism of ATF6 activation has been studied extensively, the negative regulation of ATF6 stabilization is not well understood. Here, we report that the deubiquitinase otubain 1 (OTUB1) facilitates bladder cancer progression by stabilizing ATF6 in response to endoplasmic reticulum stress. OTUB1 expression is raised in bladder cancer patients. Genetic ablation of OTUB1 markedly inhibited bladder cancer cell proliferation, viability, and migration both in vitro and in vivo. Mechanistically, luciferase pathway screening showed that ATF6 signaling was clearly activated compared with other pathways. OTUB1 was found to activate ATF6 signaling by inhibiting its ubiquitylation, thereby remodeling the stressed cells through transcriptional regulation. Our results show that high OTUB1 expression promotes bladder cancer progression by stabilizing ATF6 and that OTUB1 is a potential therapeutic target in bladder cancer.
Anticipation to Social and Nonsocial Dynamic Cues in Preschool‐Age Children
Authors: Engle Jae , Baker‐Harvey Hazel , Nguyen Hieu‐Kevin , Carney Hunter , Stavropoulos Katherine , Carver Leslie J. 
Published: March 2021

The ability to learn from expectations is foundational to social and nonsocial learning in children. However, we know little about the brain basis of reward expectation in development. Here, 3‐ to 4‐year‐olds (N = 26) were shown a passive associative learning paradigm with dynamic stimuli. Anticipation for reward‐related stimuli was measured via the stimulus preceding negativity (SPN). To our knowledge, this is the first study to measure an SPN in children younger than age 6. Our findings reveal distinct anticipatory neural signatures for social versus nonsocial stimuli, consistent with previous research in older children. This study suggests an SPN can be elicited in preschoolers and is larger for social than nonsocial stimuli.
Short communication: Cemented implant reconstructions are associated with less marginal bone loss than screw‐retained reconstructions at 3 and 5 years of loading
Authors: Strauss Franz‐Josef , Hämmerle Christoph H. F. , Thoma Daniel S. 
Published: March 2021

AbstractObjectivesTo analyse whether there is a difference in marginal bone levels (MBL) and the respective changes between cemented and screw‐retained reconstructions at 3 and 5 years of loading.MethodsRadiographic data from 14 prospective multicentre clinical trials following implant loading with fixed cemented (CEM) or screw‐retained (SCREW) reconstructions with a 3‐ to 5‐year follow‐up were retrieved from a database. MBL and MBL changes were assessed at initiation of implant loading (BL), at 3 (FU‐3) and 5 years (FU‐5) thereafter. The presence of peri‐implantitis was also determined.ResultsData from 1,672 implants at BL, 1,565 implants at FU‐3 and 1,109 implants at FU‐5 were available. The mean MBL amounted to 0.57 mm (SD 0.87) at BL, 0.55 mm (SD 0.86) at FU‐3 and 0.65 mm (SD 1.18) at FU‐5. At FU‐3, the mean MBL was 0.44 mm (SD 0.65) in group CEM and 0.63 mm (SD 0.99) in group SCREW showing a significant difference between the groups (intergroup <0.05). At FU‐5, the mean MBL was 0.42 mm (SD 0.77) in CEM and 0.80 mm (SD 1.37) in SCREW, again with significant differences between both groups (p < .05). MBL changes between BL and FU‐3 amounted to 0.11 mm (SD 1.02) (bone loss) in SCREW and −0.17 mm (SD 1.03) (bone gain) in CEM. Similarly, mean MBL changes from BL to FU‐5 amounted to 0.23 mm (SD 1.31) (bone loss) in SCREW and −0.26 mm (SD 1.27) (bone gain) in CEM. The prevalence of peri‐implantitis amounted to 6.9% in CEM and 5.6% in group SCREW (intergroup p = .29063) at FU‐3. At FU‐5, peri‐implantitis amounted to 4.6% in CEM and 6.2% in group SCREW (intergroup p = .28242).ConclusionCemented implant reconstructions compared with screw‐retained reconstructions revealed higher marginal bone levels and similar rates of peri‐implantitis during 5 years. The difference in MBL and the respective changes between the two groups, however, appear to be clinically negligible.
Bariatric surgery in the treatment of patients with obesity and type 1 diabetes: A retrospective study of clinical data
Authors: Mohammed Nagi , Buckley Adam , Elsheikh Mohgah , Allum Matthew , Suliman Sara , Al Hadad Mohammed , le Roux Carel W , Lessan Nader , Suliman Mohamed 
Published: March 2021

AbstractAimTo evaluate the effectiveness and safety of bariatric surgery in patients with coexisting type 1 diabetes and obesity who choose to undergo bariatric surgery for weight management.Materials and MethodsWe conducted a retrospective, longitudinal review of the clinical data of patients with type 1 diabetes, followed up at our centre after bariatric surgery had been performed elsewhere.ResultsSixty‐one patients were included, of whom 51% were women, and 57 (93%) were Emirati Arab, three (5%) were other Arab, and one (2%) was White in ethnic origin. The mean age at surgery was 31 years. A total of 42 patients (69%) underwent sleeve gastrectomy, 17 (28%) gastric bypass, and two (3%) gastric banding. In 48 patients with complete follow‐up data, improvements were observed at 12 months in the median (interquartile range [IQR]) values for body mass index (BMI; 38.5 [34.9‐40.9] to 26.1 [24.2‐29.6] kg/m2, P <0.001), glycated haemoglobin concentration (8.6 [7.8‐9.2]% to 7.8 [7.2‐8.5]%; P <0.001), daily insulin dose (1.0 [0.7‐1.2] to 0.8 [0.6‐0.9] units/kg/d; P <0.001), systolic blood pressure (127 [116‐136] to 116 [110‐120] mmHg; P <0.001), total cholesterol: high‐density lipoprotein cholesterol ratio (3.4 [2.9‐4.3] to 3.0 [2.6‐3.5]; P <0.001), and albuminuria. In 32 patients followed up at 3 years, the median (IQR) reduction in BMI was 10.4 (5.9‐11.7) kg/m2, 50% reduced or stopped antihypertensive medication and 58% reduced or stopped lipid‐modifying medication. Three patients each reported a single episode of diabetic ketoacidosis; in one case this was due to cessation of insulin treatment.ConclusionsIn our cohort of patients with obesity and type 1 diabetes, bariatric surgery led to significant improvements in weight and cardiometabolic variables, with modest improvements in glycaemia. Few adverse events were reported.
Randomized controlled study to examine the efficacy of hepatic arterial infusion chemotherapy with cisplatin before radiofrequency ablation for hepatocellular carcinoma
Authors: Oyama Atsushi , Nouso Kazuhiro , Yoshimura Kenichi , Morimoto Yuki , Nakamura Shinichiro , Onishi Hideki , Takaki Akinobu , Iwadou Shouta , Kariyama Kazuya , Kuwaki Kenji , Yabushita Kazuhisa , Sakaguchi Kosaku , Toshimori Jyunichi , Kobashi Haruhiko , Moriya Akio , Ando Masaharu , Okada Hiroyuki ,   Okayama Hepatocellular Carcinoma Study Group
Published: March 2021

AbstractAimHepatic arterial infusion chemotherapy (HAIC) with cisplatin is beneficial to patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib. This study aimed to examine the effect of HAIC with cisplatin before radiofrequency ablation (RFA) in patients with HCC.MethodsThis was a multicenter, single‐blinded, randomized controlled study (UMIN000007267). Early‐stage HCC patients were randomly assigned (1:1) to receive HAIC with cisplatin before RFA therapy (HAIC group) or RFA monotherapy (non‐HAIC group). The primary end‐point was recurrence‐free survival. Efficacy analysis and safety analysis followed the intention‐to‐treat principle.ResultsBetween August 2012 and July 2016, 74 patients were recruited. A total of 70 eligible patients were randomly assigned to the HAIC group (n = 35) and non‐HAIC group (n = 35). Recurrence‐free survival rates at 1 (3) year in the HAIC group and non‐HAIC group were 82.9% (54.3%) and 74.3% (34.3%), respectively (hazard ratio [HR], 0.597; 95% confidence interval [CI], 0.320–1.091; p = 0.094]. Subgroup analysis showed that the beneficial effect of HAIC was observed in patients with a single nodule and Child–Pugh score 5. Intrahepatic distant recurrence‐free survival rate in the HAIC group was significantly better than that in the non‐HAIC group (HR, 0.468; 95% CI, 0.235–0.896; p = 0.022). Adverse events were observed in just two patients in the HAIC group (6%) – grade 2 cholecystitis and grade 2 hyperkalemia.ConclusionsHAIC with cisplatin before RFA did not significantly decrease recurrence in patients with early‐stage HCC. However, it might be effective in preventing intrahepatic distant recurrence.
Negative emotions in consumer brand relationship: A review and future research agenda
Authors: Khatoon Sajira , Rehman Varisha 
Published: March 2021

AbstractEmotions have a compelling and strong effect on individuals actions and behaviours. They are elicited in consumers during the decision‐making process through brand‐related stimuli. Negative emotions towards a brand can translate directly into actions against it, for instance, propagating negative word of mouth, avoidance and vengeance. Although scholars have conducted consumer–brand relationship (CBR) research for over 20 years, our understanding of negative emotions is still limited. Research in the consumer–brand relationship domain so far has predominantly focused on positive emotions and its constructs. However, with a recent surge in the studies on negative emotions in the consumer–brand relationship domain, a systematic review is essential to identify, evaluate and synthesize the extant literature. Using a citation‐based search, we analyse 55 articles in the literature to achieve three objectives: primarily to illustrate the evolution and growth of negative emotions in the consumer–brand relationship using the seminal article by Fournier (1998) ‘Consumers and their brands: Developing relationship theory in consumer research’ as the base paper. Further, the study aims to identify uncharted negative emotions in consumer–brand relationship literature by integrating it with the hierarchical theory of emotions article and finally, it suggests future research in unexplored and underexplored negative emotions.
Theories and Theoria of the Atonement: A Proposal
Authors: Johnson Adam J. 
Published: March 2021

AbstractThis article traces the origins of language about ‘theories’ of the atonement in Friedrich Schleiermacher and F.C. Baur’s historicization of Protestant theology in Germany. It follows the growth and promulgation of this conceptualization as it spread to America and Great Britain in the later nineteenth century. This approach contributed to the growth and development of the doctrine and its history, while severely limiting it in important ways. I note four dangers implicit within uncritical use of ‘theory’ language in studies of the history of the doctrine of the atonement, and conclude by arguing that a more fitting approach lies in the ancient and medieval concept of theoria, or contemplation, which serves as the broader telos for appreciating the riches we have in the work of Christ, within which modest contemporary notions of theory can and should play a role.
Nursing interventions for perinatal bereavement care in neonatal intensive care units: A scoping review
Authors: Paraíso Pueyo Elena , González Alonso Ana Victoria , Botigué Teresa , Masot Olga , Escobar‐Bravo Miguel Ángel , Lavedán Santamaría Ana 
Published: March 2021

BackgroundDespite technological advances and specialist training of neonatal teams, perinatal deaths still occur. Such events are traumatic experiences for the parents and increase the risk of pathological grieving. Nursing is one of the main sources of support. However, the important work of nurses in these situations is made more difficult by the lack of recognized strategies that can be implemented to assist parents and family members in the bereavement process.AimIdentify nursing interventions to help parents of neonates admitted to neonatal intensive care units cope with perinatal loss.MethodsA scoping review based on the methodological framework established by Arksey and O'Malley was used. A total of 327 relevant studies were identified through a bibliographic search in Pubmed, CINAHL Plus, APA PsycNET and Scopus between 2000 and 2019. The screening process included an initial analysis of the relevance of the abstract and, when required, an extensive review of the full paper.ResultsA total of 9 papers were finally selected which responded to the research question. All nine papers are from the USA and have different methodological characteristics. A number of effective interventions were identified, including legacy creation, support groups, family‐centred accompaniment and follow‐up, parental involvement in pre‐mortem care, intergenerational bereavement programmes, and the use of technological and spiritual resources.ConclusionIn general, the scant evidence that is available about nursing interventions around perinatal bereavement care underlines the requirement to thoroughly assess the effectiveness of those that have already been designed and implemented.Implications for nursing practice and policyThis scoping review contributes to the potential implementation of effective interventions to deal with and help parents and family members cope with perinatal bereavement, with nursing staff as the main source of support and leading interventions which have family members in the care team. This review also makes a substantial contribution to the development of a practical and evidence‐based clinical guide for nursing, with recommendations that can be adapted to effective quality care criteria. It is additionally intended to encourage visibility in health policies of care and attention to perinatal grief in neonatal intensive care units.