bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of a Microservice-Based Certification Platform
Authors: Copei Sebastian , Wickert Manuel , Zündorf Albert 
Published: October 2021

AbstractInteroperability between edge devices and backend systems plays an important role for a successful digital transformation of the energy system. To provide interoperability, edge devices as well as backend systems use standardized communication protocols. Vendors of such systems often certify their products to verify compatibility to a certain version of communication protocol standard. Since standardization and certification processes are classically very time consuming, they seem to be incompatible with agile software development. Therefore we proposed an agile standardization and certification approach. Here we will present a basic implementation of a microservice based certification platform that supports certification as a service. The platform allows software vendors to integrate certification of their products directly in their continuous delivery pipeline. This will lay the ground for the evaluation of certification as a service in a concrete scenario.
From Project to Product
Authors: Philip Matthew , Thirion Yoan 
Published: October 2021

AbstractAs technical advances have enabled organizations to deliver software to the market faster, in turn shortening the feedback loop for new ideas and spurring innovation, legacy organizations need to update their mindset from a project-driven to a product-driven approach or risk being displaced by product-native organizations. This poster shows the high-level principles that represent our experience guiding organizations with a project-to-product approach.
Is Your Software Ecosystem in Danger? Preventing Ecosystem Death Through Lessons in Ecosystem Health
Authors: Evertse Robert , Lencz Abel , Šinik Tea , Jansen Slinger , Soussi Lamia 
Published: October 2021

AbstractThe health of an ecosystem is by definition the most basic requirement for its survival. This paper aims to examine the driving forces behind the health of software ecosystems, in a comparative manner between four different ecosystems which have experienced a major downfall. We examine these ecosystems for similarities, from which demise principles are derived. Consequently, countermeasures are proposed in an attempt to combat these demise principles. The findings show that the main demise principles are Underestimation of competitors, Lack of innovation, and Incorrect management of the ecosystem. The proposed countermeasures to address these demise principles are to Increase market awareness to increase competitive advantage, Increase product quality, Increase platform quality, Adjust value propositions and Formulate a partner-oriented strategy.
Disaster Healthcare Workers’ Experience of Using the Psychological First Aid Mobile App During Disaster Simulation Training
Authors: Choi Yun-Jung , Jung Hae-Sun , Choi Eun-Ju , Ko Eunjung 
Published: October 2021

Abstract

Objective:
The study aimed to examine the experience of disaster healthcare workers with simulation training using the Psychological First Aid (PFA) mobile app.

Methods:
This study was designed using qualitative research methodology with focus group interviews. The participants were 19 disaster healthcare workers from community mental health service centers who attended disaster simulation training in flood, fire, or leakage of hazardous chemicals. Before the simulation, participants were provided the PFA mobile app and allowed to practice the PFA techniques to apply them during the simulation. Data were collected through focus group interviews and qualitatively analyzed using the content analysis method.

Results:
The findings were divided into 6 categories: experience in realistic disaster situations, satisfaction with education methods using a mobile app, effectiveness of the PFA app in disaster relief, confidence in disaster relief by integrating experience and knowledge of the PFA app, self-reflection as a disaster healthcare worker, and identifying limitations and making developmental suggestions.

Conclusions:
Based on the participants’ developmental proposals in this study, the disaster simulation training, incorporating improvements in the disaster simulation training and the PFA app features, will serve as a new framework for disaster support education and systematic mental health services to survivors by disaster healthcare workers.
Geophysical and Geochemical Evidence for a New Mafic Magmatic Province Within the Northwest Shelf of Australia
Authors: Yule C. T. G. , Spandler C. 
Published: October 2021

AbstractThe formation of mafic magmatic provinces are significant geological events that can drive mass extinctions and continental rifting and can influence basin evolution, petroleum prospectivity and mineralization. Buried magmatic provinces, however, are rarely identified and difficult to define. The Northwest Shelf of Australia contains large volumes of potentially interconnected mafic igneous material across several sedimentary basins. However, limited study and a lack of surface exposure have prevented detailed description and classification of these rocks. In this study, the distribution and composition of these mafic igneous rocks are described using an integrated geophysical and geochemical approach, which included over 10,000 km line length of 2D seismic data, well log data and chemical analysis of samples from 14 wells across the Browse, Roebuck, Canning and North Carnarvon basins. Using this combined data set, we demonstrate interconnectivity of buried mafic igneous rocks across the Northwest Shelf and calculate a total surface area exceeding 280,000 km2 and a cumulative minimum volume of ∼140,000 km3. Petrology and geochemistry of samples indicate they are basaltic and doleritic with alkaline and sub‐alkaline compositions and formed in a continental rift setting. Collectively, the igneous rocks meet the criteria for classification as a mafic magmatic province (MMP) and closely match the criteria required for classification as a large igneous province (LIP). Emplacement of the newly defined Northwest Shelf MMP may represent hotspot magmatism that could have initiated rifting of the Cimmerian Block from NW Australia during the Permian and could have potential for future, large scale CO2 sequestration and storage.
MAVEN Observations of Magnetic Reconnection at Martian Induced Magnetopause
Authors: Wang Jing , Yu Jiang , Xu Xiaojun , Cui Jun , Cao Jinbin , Ye Yudong , Xu Qi , Wang Ming , Zhou Zilu , Chang Qing , Xu Jiaying , Wang Xing 
Published: October 2021

AbstractThe Martian‐induced magnetopause (IMP), characterized by the sudden changes of magnetic fields and ion compositions, is the transition boundary separating the magnetosheath from Martian induced magnetosphere. Based on the magnetic field and plasma measurements by Mars Atmosphere and Volatile EvolutioN, we for the first time report a magnetic reconnection at the dayside IMP. The clear plasma jet and bipolar Hall magnetic field provide solid evidence for the identification of the magnetic reconnection. Our observations demonstrate that the newly arrived interplanetary magnetic field and the anchored magnetic field in the induced magnetosphere can reconnect with each other at the IMP. Such reconnection allows the planetary ions to escape from Mars through the reconnected magnetic fields across the IMP, resulting in a significant increase in the local loss rate of the ionospheric ions.
Long-term protective immunity induced by an adjuvant-containing live-attenuated AIDS virus
Authors: Okamura Tomotaka , Shimizu Yuya , Asaka Masamitsu N. , Kanuma Tomohiro , Tsujimura Yusuke , Yamamoto Takuya , Matsuo Kazuhiro , Yasutomi Yasuhiro 
Published: October 2021

AbstractThe use of an adjuvant in vaccination is thought to be effective for enhancing immune responses to various pathogens. We genetically constructed a live attenuated simian human immunodeficiency virus (SHIV) to express the adjuvant molecule Ag85B (SHIV-Ag85B). SHIV-Ag85B could not be detected 4 weeks after injection in cynomolgus macaques, and strong SHIV-specific T cell responses were induced in these macaques. When the macaques in which SHIV-Ag85B had become undetectable were challenged with pathogenic SHIV89.6P at 37 weeks after SHIV-Ag85B had become undetectable, SHIV89.6P was not detected after the challenge. Eradication of SHIV89.6P was confirmed by adoptive transfer experiments and CD8-depletion studies. The SHIV-Ag85B-inoculated macaques showed enhancement of Gag-specific monofunctional and polyfunctional CD8+ T cells in the acute phase of the pathogenic SHIV challenge. The results suggest that SHIV-Ag85B elicited strong sterile immune responses against pathogenic SHIV and that it may lead to the development of a vaccine for AIDS virus infection.
Keratoconus patients exhibit a distinct ocular surface immune cell and inflammatory profile
Authors: D’Souza Sharon , Nair Archana Padmanabhan , Sahu Ganesh Ram , Vaidya Tanuja , Shetty Rohit , Khamar Pooja , Mullick Ritika , Gupta Sneha , Dickman Mor M. , Nuijts Rudy M. M. A. , Mohan Rajiv R. , Ghosh Arkasubhra , Sethu Swaminathan 
Published: October 2021

AbstractInflammatory factors have been considered to contribute to keratoconus (KC) pathogenesis. This study aims to determine the immune cells subsets and soluble inflammatory factor profile on the ocular surface of KC patients. 32 KC subjects (51 eyes) across different grades of severity and 15 healthy controls (23 eyes) were included in the study. Keratometry and pachymetry measurements were recorded. Ocular surface immune cells (collected by ocular surface wash) immunophenotyped using flow cytometry include leukocytes, neutrophils, macrophages, natural killer (NK) cells, pan-T cells, gamma delta T (γδT) cells and NKT cells. Tear fluid collected using Schirmer’s strip was used to measure 50 soluble factors by multiplex ELISA. Proportions of activated neutrophils, NK cells and γδT cells were significantly increased in KC patients. Significantly higher levels of tear fluid IL-1β, IL-6, LIF, IL-17A, TNFα, IFNα/β/γ, EPO, TGFβ1, PDGF-BB, sVCAM, sL-selectin, granzyme-B, perforin, MMP2, sFasL and IgE, along with significantly lower levels of IL-1α and IL-9 were observed in KC patients. Alterations observed in few of the immuno-inflammatory parameters correlated with grades of disease, allergy, eye rubbing and keratometry or pachymetry measurements. The observation implies a distinct immuno-inflammatory component in KC pathogenesis and its potential as an additional therapeutic target in KC management.
Modelling and analysis of decentralized energy systems with photovoltaic, micro-hydro, battery and diesel technology for remote areas of Nepal
Authors: Sanjel Nawaraj , Baral Bivek 
Published: October 2021

Abstract
Remote areas of Nepal suffer from limited or no access to electricity. Providing electricity access in remote areas is one of the foremost challenges of any developing country. The purpose of this study is to develop and propose a reliable and low-cost model for electrification. The study presents an optimized choice between decentralized renewable-energy systems and grid expansion. Opting for an analytical method for the modelling and analysis of electrification options based on life-cycle cost (LCC) and economic distance limit, each energy system for varied load conditions is compared for a better option. A framework for energy-system selection based on available resources is proposed. It compares the grid-expansion option with potential isolated renewable-energy systems to ensure energy access to the area under consideration. Additionally, off-grid configurations that rely on renewable energy sources are also considered for the necessity of backup supply to ensure continuous power to the research area. Techno-economic assessment is carried out for different off-grid and hybrid configurations proposed in this study and their feasibility checks are carefully examined. Commercial efficacy of the proposed hybrid energy systems is assessed by comparing the life cycle and energy cost and by performing different additional sensitivity analyses. The study concludes that reduced generation cost supports the increasing penetration of electrification. The LCC for grid expansion is the most economical under high-load conditions, whereas for the isolated and sparsely settled populations with low-load conditions, photovoltaic power backed up with a diesel generator is the most economical.
Outcome of 5-years active cardiological management of oncohematological patients on targeted therapy
Authors: Emelina E , Gendlin G , Nikitin I 
Published: October 2021

Abstract

Background
The overall survival of oncohematological patients (pts) depends not only on the severity of the cancer, the anticancer therapy used and the comorbidity of the pts. The most important role in the management of these pts is played by the supervision of a cardiologist.

Purpose
To assess the effect of active cardiac management on the overall survival of oncohematological pts on targeted therapy with ibrutinib.

Methods
We examined and observed in dynamics for 5 years 217 pts with chronic lymphocytic leukemia (CLL), constantly receiving ibrutinib, inducing arterial hypertension (AH) and atrial fibrillation (AF) in a part of the pts. All pts underwent echocardiography (Echo), 24-hour Holter ECG monitoring (HM), assessment of comorbidity using the Charlson index and screening of fragility using the G8 questionnaire. Everyday measurement of blood pressure, heart rate in the morning and in the evening with keeping a measurement diary was recommended for all pts, but 89 pts were performed, who constantly contacted us remotely using instant messengers and formed an active cardiac management (ACM) group.

Results
We studied the overall survival of pts with CLL receiving targeted therapy with ibrutinib, depending on cardiac monitoring, starting from the first visit. The age of pts in the ACM group (n=89) and in other pts (n=138) did not differ and amounted to 66.0 (60.0–70.0) years and 66.0 (59.0–74.0) years respectively. The number of men and women in the groups was comparable. In the ACM group, there were significantly more pts with AH - 86.5% and with AF - 42.7% compared to 50.4% with AH and 15.9% with AF in the rest of the pts (p&lt;0.0001 in both cases) and a comparable number of pts with coronary artery disease. According to the screening HM, there were more pts with short AF episodes in the ACM group - 31.4% versus 8.0% in the rest of the pts (p&lt;0.0001). Accordingly, the number of pts who received cardiological treatment in the ACM group was 87.6%, in the group of other pts - 53.6% (p&lt;0.0001). Echo parameters did not differ in the groups. Indicators that significantly affect survival in the general group (Charlson index, scores of the G8 questionnaire) did not differ significantly in the ACM group and in other pts with CLL. The groups also did not differ in hematological status and the number of cases of second tumors. At the same time, despite a significantly more pronounced cardiac comorbidity, oncohematological pts under active cardiac monitoring, including continuous remote monitoring, demonstrated better survival compared to other pts (p&lt;0.0001).

Conclusions
Conducting active cardiac management, including constant remote observation, allows achieving higher overall survival rates of hematological cancer patients, despite a more severe cardiac status compared to other pts under periodic supervision of a cardiologist.

Funding Acknowledgement
Type of funding sources: Public Institution(s). Main funding source(s): no founding sources
Doxorubicin induced cardiotoxicity is mediated by increased CerS2 expression and ceramide accumulation in vitro and in vivo
Authors: Kretzschmar T , Wu J M F , Bekhite M , Gruen K , Bogoviku J , Mueller T , Graeler M , Franz M , Schulze P C 
Published: October 2021

Abstract

Background
Doxorubicin (Dox) is a chemotherapeutic drug with cardiotoxicity as a severe side effect. Interestingly, Dox increases the expression of ceramide synthase 2 (CerS2) and increases long- chain ceramide levels with proinflammatory effects.

Aim
The purpose of our study was to identify the role of increased long- chain ceramides synthesized by CerS2 in Dox mediated cardiotoxicity in vitro and in vivo.

Methods
We incubated HL-1 cells (murine cardiomyocytes) with 0.7 μM Dox for 24h. In parallel cells were pretreated with fumonisin B (100 μM, 4h, FuB) to reduce Dox effects. We generated CerS2 ko mice and treated them with Dox and also generated doxycycline- inducible CerS2 mice. Expression of genes and proteins were measured with immunofluorescence (IF), western blot (WB) or qPCR. Ceramide levels were determined with mass spectrometry. Cellular staining was assessed by confocal laser scanning microscopy. Mitochondrial viability and activity were detected using seahorse analyzer.

Results
Protein expression measurement showed increased CerS2 level in vitro (2.4±0.32, p=0.03 for WB, 2.2±0.10, p&lt;0.001 for IF). Coherently, very long chain ceramides were increased with the highest peak for C16:0 (1.9±0.04, p&lt;0.001). FuB pretreatment reduced most ceramides to normal levels. Dox increased mRNA level of TNFα (6.0±0.48, p&lt;0.001), IL-6 (4.6±0.37, p&lt;0.001), IL-1β (46.2±0.59, p=0.05) and BNP (4.7±0.46, p=0.03). FuB reduced IL-1β (20.1±0.23, p=0.002) and BNP (2.3±0.05, p=0.01) expression. Dox reduced mitochondria fusion related genes MFN1 (0.7±0.18, p=0.02) and MFN2 (0.3±0.37, p=0.01) and increased mitochondria fission related genes Mff (1.5±0.22) and FIS1 (1.5±0.18). FuB returned Mff and FIS1 expression to normal levels. Mitochondrial ATP production was reduced with Dox (0.3±0.19, p&lt;0.001) and was slightly improved with FuB (0.5±0.12, p&lt;0.001). Dox led to increased cleaved Casp3/Casp3 ratio (64.9±0.61, p=0.04). In vivo CerS2 overexpression showed comparable results as well as increased fibrosis.

Conclusion
Our data show that Dox mediated cardiotoxicity is in part mediated by CerS2 and ceramides. CerS2 could be a valuable drug target for treatment of chemotherapy- associated cardiomyopathies.

Funding Acknowledgement
Type of funding sources: None. Immunofluorescence HL-1
Cefazolin susceptibility of coagulase-negative staphylococci (CoNS) causing late-onset neonatal bacteraemia
Authors: Marr I. , Swe K. , Henderson A. , Lacey J. A. , Carter G. P. , Ferguson J. K. 
Published: October 2021

Abstract

Background
CoNS bacteraemia causes significant neonatal morbidity. Previous work has suggested that β-lactam antibiotics vary in their binding affinity to PBP2a (produced by the mecA gene) present in most CoNS.

Objectives
We evaluated cefazolin MICs for CoNS isolated in an Australian neonatal ICU (NICU) and correlated them with isolate genotype and phenotype.

Methods
Significant blood isolates from 2009 to 2017 were speciated and underwent broth microdilution testing for cefazolin, cefoxitin, oxacillin and flucloxacillin. Correlation with mecA presence and PBP2a expression was evaluated. A selection of Staphylococcus capitis isolates underwent WGS.

Results
The CoNS (n = 99) isolates were confirmed as S. capitis (n = 57), Staphylococcus epidermidis (n = 32), Staphylococcus haemolyticus (n = 2) and Staphylococcus warneri (n = 8). The MIC of cefazolin was ≤2 mg/L for 30% of isolates and 75% had an MIC of ≤8 mg/L (MIC90 = 16 mg/L). This contrasted with MIC90s of cefoxitin, oxacillin and flucloxacillin, which were all ≥32 mg/L. WGS found a number of S. capitis isolates closely related to the globally established NRCS-A clone.

Conclusions
CoNS displayed distinctly lower MIC values of cefazolin than of other agents tested. MIC variation may be related to binding affinity of PBP2a or regulation of expression of mecA by mecR1-mecI functional genes. Further, NRCS-A S. capitis strains were present in this Australian NICU before and after the unit underwent physical relocation, which raised questions about a common environmental source. It is considered justified to conduct a randomized clinical trial that assesses cefazolin versus vancomycin for management of late-onset neonatal sepsis.
Simple bone cyst of spinal vertebrae: two case reports and literature review
Authors: Safaei Saeid , Athari Mirbahador , Azimi Parisa , Mirbolook Ahmadreza , Yazdanian Taravat , Hamzehzadeh Farhad 
Published: October 2021

Abstract
Simple bone cyst (SBC) is not a common lesion in the spine and especially in the vertebral body. We intend to report two cases of SBC located in the vertebral body, and review the literature. Two cases include a 24 year-old male and 26 year-old male with vertebral body lesion of T12 and L5 vertebrae,retrospectively. Both lesions were found to be SBC and confirmed by pathology. Both cases were managed with surgery, the cavity was filled with bone graft and posterior spinal fusion and instrumentation with pedicle screws, and rods were carried out. There was no recurrence. There have been 21 cases of SBCs in English literature, and only 8 cases have been reported in the vertebral body. SBC is a rare benign lesion in the spine and it should be considered in the differential diagnosis when suggested by radiologic investigations.
Incidental finding of a gastric schwannoma: a case report
Authors: Cruz Centeno Nelimar , Suarez Dominguez Albert , Mojica Mañosa Pablo , Carlo Victor P 
Published: October 2021

Abstract
Gastric schwannomas are rare peripheral nerve sheath tumors which are usually found incidentally while undergoing workup for other conditions. Despite their benign nature, they require surgical resection with negative margins. It is important to differentiate gastric schwannomas from gastrointestinal stromal tumors prior to surgical excision, as this can alter the recommended surgical plan. This can be achieved with endoscopic ultrasound and fine needle aspiration with analysis of the sampled tissue using immunohistochemical stains. We present the case of a 68-year-old female patient with an incidental finding of a gastric fundus schwannoma. Laparoscopic gastric wedge resection was performed with complete excision of the tumor and negative margins. Pathology was confirmed with immunohistochemical stains positive for S-100 and negative for CD117 and DOG1. Post-operative recovery was uneventful without tumor recurrence.
Techniques of Justice: W. E. B. Du Bois’s Data Portraits and the Problem of Visualizing the Race
Authors: Fusco Katherine , Olman Lynda C. 
Published: October 2021

AbstractThis essay responds to recent calls for a closer examination of visualizations of race in multi-ethnic literature by revisiting the work of W. E. B. Du Bois in this area: particularly, the infographics he created for the 1900 Paris Exposition and the covers he commissioned for The Crisis during his editorship of that journal. Utilizing an approach derived from Foucault’s theories of panopticism, we consider how Du Bois engaged contemporary visual stereotypes of Blackness. First, Du Bois engaged the analytic mode of panopticism in order to break down existing stereotypes of black communities and reveal their diversity and similarities to white communities. Then, Du Bois engaged the synoptic mode to create new, elegant, and abstract visual stereotypes of black achievement and excellence. Our analysis provides valuable context to previous critiques of Du Bois’s elitism by demonstrating it to be—in the visual realm at least—an inevitable consequence of attempting to replace one panoptic stereotype with another: panopticism tends to support rather than subvert hegemony. Notwithstanding, Du Bois’s infographics, with their analytic interventions and visual abstractions, point to techniques for intervening in the visualization of race that bear further investigation in his wider body of scientific and editorial work.