bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peningkatan Kesejahteraan Barefoot Entrepreneurs Melalui Pemanfaatan Limbah Pasar Di “Pasar Semangat Dalam”
Authors: Anisah Hastin Umi , Claudia Meiske , Wandary Wimby , Yulianti Raden Roro , Sangen Marijati 
Published: November 2021

This service activity aims to empower MSMEs, traders associations in the “Semangat Dalam” Market (barefoot entrepreneurs) so that in the end they can improve their welfare. The approach method to achieve the goals of the service activities carried out is to provide counseling to the target audience - through the delivery of discourse to open insights or bring up new ideas in their entrepreneurial activities. The target audience is a handful of market traders located at Jalan Semangat Dalam, Hadil Bhakti. The result of this service activity is the opening of the target audience's insight so that they are willing and able to make more efforts in utilizing market waste that has the potential to increase the variety of trade products, and to be more introspective not to get involved with debt, especially from loan sharks in an effort to increase the variety of their trading products. Keywords: barefoot entrepreneurs, MSME’s, market waste utilization
Definition of the Snoring Episode Index Based on the Analyses of Snoring Parameters and the Apnea Hypopnea Index
Authors: Kim Su Geun , Cho Sung-Woo , Kim Jeong-Whun 
Published: November 2021

Abstract
Objective

Although snoring is the most common subjective symptom in obstructive sleep apnea (OSA), an international consensus on the definition of snoring is lacking. This study aimed to define snoring by analyzing correlations between snoring parameters and the apnea hypopnea index (AHI).
Methods

We retrospectively analyzed the polysomnography data of patients with OSA. A snoring event was defined when airflow pressure was >200 microbar. We included four snoring parameters. Snoring percentage was defined as the cumulative time of snoring events divided by total sleep time. A snoring episode was defined as the occurrence of ≥3 consecutive snoring events, and the snoring episode index was defined as the number of snoring episodes per hour. The average and longest durations of snoring episodes were also investigated.
Results

The study enrolled 5,035 patients. Their mean AHI was 26.5/h and the mean snoring episode index was 19.2/h. Although the four snoring parameters showed significant correlations with the AHI, the snoring episode index showed the strongest positive correlation with the AHI (r = 0.741, P < 0.001).
Conclusion

The snoring episode index may be used as a definition of snoring from the perspective of a highly positive correlation with the AHI.
Diagnostic Value of Endoscopic Retrograde Cholangiopancreatography Combined with Serum C-Reactive Protein, CEA and IL-6 in Occult Common Bile Duct Stones
Authors: Lu ShiJun , Liu XueLi , Wu WeiGuo 
Published: November 2021

Abstract
Objective: To investigate the diagnostic value of ERCP combined with CRP, CEA and IL-6 in serum in Occult Common bile duct stones (CBDS). Methods: 80 cases of patients with occult CBDS treated in our hospital were selected as the research subjects, and the diagnosis rates of ERCP alone or ERCP combined with CRP, CEA and IL-6 in serum were compared. Results: Versus ERCP alone, the diagnosis rate of combined diagnosis was clearly higher (P < 0.05). Versus patients without CBDS, the levels of CRP, CEA and IL-6 in serum in CBDS patients were apparently elevated (P < 0.05). The levels of CRP, CEA and IL-6 in serum were of high value in the diagnosis of CBDS in patients with occult CBDS (P < 0.05). Conclusion: ERCP combined with CRP, CEA and IL-6 in serum is of high value in re-diagnosis of Occult CBDS.
Understanding Attitudes and Obstacles To Vaccination Against COVID-19 in Patients With Primary Immunodeficiency
Authors: Aberumand Babak , Goulstone Whitney Ayoub , Betschel Stephen 
Published: November 2021

Abstract
Background

Patients with primary immunodeficiency (PID) are at increased risk for infections such as SARS-CoV-2 (COVID-19), due to the nature of their diseases and being immunocompromised. At this time, four vaccines against COVID-19 (Pfizer-BioNtech’s Comirnaty ®, Moderna’s Spikevax ®, AstraZeneca’s Vaxzevria®, Johnson & Johnson’s Janssen ®) have been approved for use by Health Canada. Due to the novelty of these vaccines, clinical studies in patients with PID are ongoing. Despite limited evidence, Canada’s National Advisory Committee on Immunization (NACI) recommend that patients with PID without any contraindications should be vaccinated with any of the approved vaccines as the potential benefits of being immunized against the virus likely outweigh the risks of contracting a severe infection. The aim of this study was to understand the perceptions regarding COVID-19 vaccination among patients with PID and to identify specific factors related to vaccine hesitancy.
Methods

The Canadian Immunodeficiencies Patient Organization (CIPO) conducted an online survey of its members to evaluate uptake of the COVID-19 vaccines by patients with PID. Data was collected using a self-administered online questionnaire. The survey was conducted between March and April 2021.
Results

At the time of survey, among 370 respondents who had not received the COVID-19 vaccine, 302 respondents (81.6%) indicated they were very or somewhat likely to get vaccinated against COVID-19; and 68 respondents (18.4%) indicated they were somewhat or very unlikely, undecided, or not planning to get vaccinated. A large majority of respondents indicated they had a diagnosis of PID (67.8%) and/or specified their type of PID (27.7%). The most common reason for vaccine hesitancy was primarily due to uncertainty about immune response given an underlying immunodeficiency. Other concerns included unknown long-term side effects of COVID-19 vaccination, pre-existing history of allergic reactions, limited amount of data, lack of investigation of safety and effectiveness of COVID-19 vaccines in those with medical conditions, and skepticism of the underlying science and/or the medical system.
Conclusions

The results point to the importance of ongoing patient outreach, education, and up-to-date information on the rapidly evolving scientific knowledge and evidence on COVID-19 relevant to the PID community, from clinical trials to real-world evidence and observational studies.
Cytochrome P450 2E1 Predicts Liver Retrieval from Donation After Circulatory Death Using Air-Ventilated Normothermic Machine Perfusion
Authors: Shi Ji-Hua , Yang Dong-Jing , Jin Qiang , Cheng Nuo , Shi Yuan-Bin , Bai Yang , Yu Dong-Sheng , Guo Wen-Zhi , Ge Guang-Bo , Zhang Shui-Jun 
Published: November 2021

Abstract
The optimal oxygen concentration is unclear for normothermic machine perfusion (NMP) of livers from donation after circulatory death donors (DCD). Our purposes were to investigate the effect of air-ventilated NMP on liver retrieval from DCD rats, and to analyze the underlying mechanism. Normothermic liver perfusion was performed using the NMP system with either air ventilation or oxygen ventilation for 2h in the rat liver following warm ischemia and cold ischemia preservation. Proteomics and metabolomics were used to reveal the significant molecular networks. The bioinformation analysis was validated by administering peroxisome proliferator activator receptor-γ (PPARγ) antagonist and agonist via ex vivo perfusion circuit in the air-ventilated NMP. Results showed that air-ventilated NMP conferred a better functional retrieval and a less inflammatory response in the rat DCD liver; integrated proteomics and metabolomics analysis indicated that intrahepatic docosapentaenoic acid (DPA) downregulation and upregulation of cytochrome P450 2E1 (CYP2E1) expression and activity were associated with DCD liver retrieval with air-ventilated NMP; PPARγ antagonist worsened liver function under air-oxygenated NMP whereas PPARγ agonist played the opposite role. In conclusion, air-ventilated NMP confers a better liver retrieval from DCD rats through the DAP-PPARγ-CYP2E1 axis; CYP2E1 activity provides a biomarker of liver retrieval from DCD.
Novel Preparation of Functional β–SiC Fiber based In 2 O 3 Nanocomposite and Controlling of Influence Factors for the Chemical Gas Sensing
Authors: Otgonbayar Zambaga , Joo Young Jun , Cho Kwang Youn , Park Sang Yul , Park Kwang Youl , Oh Won-Chun 
Published: November 2021

Abstract
The gas sensing ability of a pure SiC fiber is limited due to its low-sensitivity and selectivity with poor recovery time during a gas sensing test. The combination of functional β-SiC fibers with metal- oxide (MO) can lead to excellent electronic conductivity, boosted chemical activity, and high reaction activity with the target gas and SiC-In2O3 sensor material. Influence factors such as amounts of MO, current collectors, and gas species (CO2, O2 and without gas) for the gas sensing ability of SiC-In2O3 nanocomposite were determined at standard room temperature (25°C) and high temperature (350°C) conditions. The gas sensing ability of the functional β–SiC fiber was significantly enhanced by the loading of In2O3 metal-oxide. In addition, the MO junction on the β–SiC fiber was mainly subjected to the Si-C-O-In bond sensor layer with an effective electron-transfer ability. The gas sensing mechanism was based on the transfer of charges, in which the sensing material acted as an absorber or a donor of charges. The sensor material could use different current- collectors to support the electron transfer and gas sensing ability of the material. A 1:0.5M SiC-In2O3 coated Ni-foil current collector sensor showed better sensing ability for CO2 and O2 gases than other gas sensors at room temperature and high temperature conditions. The sensing result of the electrode was obtained with different current density values without or with gas purging conditions because CO2 and O2 gases had electron acceptor properties. During the gas sensing test, the sensor material donated electrons to target gases. The current value on the CV graph then significantly changed. Our obtained sample analysis data and the gas sensing test adequately demonstrated that MO junctions on functional β–SiC fibers could improve the sensitivity of a sensor material and particularly upgrade the sensor material for gas sensing.
Data Analytical Approach for Regional Variation of Incidence Rates for Asthma and Other Chronic Obstructive Lung Diseases in Oman
Authors: Wesonga Ronald , Abdelbasit Khidir 
Published: November 2021

Abstract
Background

This study aimed to examine regional differences for asthma and other chronic obstructive lung diseases. Information pertaining influence of region on asthma is not well established.
Method

The study was based on data collected from annual reports produced by the Ministry of Health over a ten-year period beginning from 2010 to 2019. Incidence rates per 10000 populations for the eleven regions in the Sultanate of Oman were analyzed using statistical tools including; analysis of variance and binary logistic regression model to determine the effect of region on asthma and other chronic obstructive lung diseases.
Results

The incident rates were found to be significantly different by region (F-value=27.07, p=0.00). There was no significant variation by year (F-value=1.05, p>0.407). Overall over the ten-year period the incidence rates stagnated between 250 and 300 per 10000 of the population, but showed a reducing trend between 2016 and 2019. The logistic regression model shows that compared to the Muscat region, all the other regions had significant increased odd ratios.
Conclusion

There is a significant evidence of regional variation in the incidence of asthma and other chronic obstructive lung diseases. This implies probable characteristics in geographical regions that are associated with asthma and other chronic obstructive lung diseases’ exacerbation. Five asthma-region classifications were identified from our analysis. Findings of this study may be used to guide decision making towards the management and control of asthma and chronic obstructive lung diseases.
Influence of ultrasound-guided fine needle aspiration biopsy on cervical lymph node metastasis and prognosis of papillary thyroid microcarcinoma
Authors: Min Ding , Zhao Zhifeng , Xu Dan , Lin Tingyu , Shen Dongjie , Xie Rongli , Fei Jian 
Published: November 2021

Abstract
Purpose

To analyze the potential association between UGFNA and cervical lymph node metastasis (CLNM) of papillary thyroid microcarcinoma (PTMC) and whether it would influence the long-term prognosis of PTMC. Then we could give advice for the application of UGFNA for thyroid nodules less than 1cm.
Methods

A total of 367 adult patients with PTMC who underwent thyroidectomy in our hospital during January 2014 and December 2015 were enrolled in this retrospective cohort study. Univariate and multivariate analysis were conducted to explore the potential risk factors of CLNM. Propensity score (PS) matching was performed to select patients with homogeneous baseline characteristics. Then the rate of CLNM was compared in matched samples by chi-squared (χ2). Survival analysis was made by Kaplan-Meier method in PS-matching cohort.
Results

CLNM rate in PS-matching cohort showed no significant difference between UGFNA group and non-UGFNA group. (29.5% vs 23.7%, P>0.05). Multivariate analysis showed that male sex (OR=3.997, 95%CI 2.148~7.439, P<0.01), larger tumor size (OR=2.319, 95%CI 1.285~4.186, P<0.01) were independent risk factors of CLNM. With a median follow-up of 63.8 months (range 3.1-84.9 months), the 5-year cumulative recurrence-free survival (RFS) rate was 99.3% in UGFNA group and 97.7% in non-UGFNA group. After PS-matching, Kaplan-Meier curves showed no significant difference from each other (P >0.05).
Conclusions

UGFNA was a very safe diagnostic tool, which would not influence the CLNM rate and long-term prognosis of patients with PTMC. Regardless of the costs, we recommend routine UGFNA for suspicious thyroid nodules ≦1cm.
Risk Factors for Injuries in Female Soldiers: a Systematic Review
Authors: Schram Ben , Canetti Elisa , Orr Rob , Pope Rodney 
Published: November 2021

Abstract
Background: Female soldiers form an integral part of any modern defence force. Previous reports have highlighted that female soldiers report injuries at higher rates than male personnel. One possible reason for this is an actual difference in underlying injury rates, purported to be due to several factors, including levels of fitness. The aim of this review was to determine risk factors for injuries in female soldiers. Methods: A systematic search was conducted for studies which reported on risk factors for injuries in female soldiers. Databases searched included PUBMED, CINAHL and Medline through OVID. Eligible studies were rated for their methodological quality using the Critical Appraisal Skills Program (CASP) tools and data were extracted and synthesized using a critical narrative approach. Results: A total of 18 articles were included in this review which reported on 18 risk factors for injury. Smoking, previous injury, no history of deployment, heavy occupational tasks, lower levels of aerobic fitness and lower number of push-up repetitions appear to be risk factors for injuries in female soldiers. Age, height, body fat, high or low BMI and body mass do not appear to be consistent risk factors for injury in female soldiers and there appears to be minimal evidence for current levels of activity, sit-up ability, and other assessments of strength, power, speed, or movement being associated with injury risk. Additionally, neither flexibility nor previous levels of activity appear to be associated with injury risk in female soldiers. Conclusion: Strategies to improve aerobic fitness and upper limb endurance, reduce smoking, and optimise rehabilitation from injuries and risk management for heavy occupational tasks need to be developed for female soldiers. Such strategies are also likely to reduce risks for male soldiers.
Serum proteomics reveals the proteomic characteristics involved in the progressive feature of acute ischemic stroke (AIS)
Authors: Lai Minchao , Zhang Xiaojun , Zhou Danya , Zhang Xiaojuan , Zhu Mengting , Liu Qingxian , Wang Dian 
Published: November 2021

Abstract
Background

To distinguish acute progressive ischemic stroke (APIS) from acute non-progressive ischemic stroke (ANPIS) is clinically critical for the precise treatment and prevention of acute ischemic stroke (AIS) deterioration. Serum proteins could reflect the unique pathophysiological processes of APIS. It is expected to find serum protein biomarkers to identify APIS at the early state, especially when typical symptoms have not been present in conventional clinical indices.
Methods

We recruited 178 subjects, including 133 AIS patients and 45 healthy controls. The discovery set, which included 10 age- and sex- matched cases from each of the APIS, ANPIS and control groups, was used for serum proteomic analysis with a mass spectrometry-based proteomics. The disrupted proteins of APIS were screened, of which, those common to ANPIS and specific to APIS were particularly concerned. Potential biomarkers of APIS were screened based on the theoretical knowledge to explain the mechanism and diagnostic value, and subsequently tested in the validated set (25 APIS patients, 88 ANPIS patients, and 35 controls).
Results

We found that 46 serum proteins were disturbed in the APIS patients; 23 differentially expressed proteins (DEPs) were common to these two groups, and 23 DEPs were associated with APIS alone. Enrichment analysis suggested that complement activation, cytolysis, proteolysis, positive regulation of fibrinolysis, blood coagulation were specifically associated with APIS; while inflammatory response, neutrophil chemotaxis, oxygen transport, and positive regulation of cell death process were common to AIPS and ANPIS. Serum amyloid A1 (SAA1) and S100 calcium binding protein A9 (S100-A9) jointly conferred a moderate value (AUC = 0.799) to diagnose APIS and to distinguish APIS from ANPIS (AUC = 0.699).
Conclusions

This study provides human serum proteomic evidence that inflammation, oxidative stress, and necrosis in APIS are common to ANPIS; the progressive feature of APIS may be mainly associated with complement activation, more serious inflammation, and lipid metabolic disorder; SAA1 and S100-A9 may be considered as potential biomarker panel of APIS.
Phase I Pharmacokinetic Study of Single Agent Trametinib in Patients With Advanced Cancer and Hepatic Dysfunction
Authors: Voon Pei Jye , Chen Eric X. , Chen Helen X. , Lockhart Albert C. , Sahebjam Solmaz , Kelly Karen , Vaishampayan Ulka N. , Subbiah Vivek , Razak Albiruni R. , Renouf Daniel J. , Hotte Sebastien J. , Singh Arti , Bedard Philippe L. , Hansen Aaron R. , Ivy S. Percy , Wang Lisa , Stayner Lee-Anne , Siu Lillian L. , Spreafico Anna 
Published: November 2021

Abstract
BackgroundTrametinib is an oral MEK 1/2 inhibitor, with a single agent recommended phase 2 dose (RP2D) of 2 mg daily (QD). This study was designed to evaluate RP2D, maximum tolerated dose (MTD), and pharmacokinetic (PK) profile of trametinib in patients with advanced solid tumors who had various degrees of hepatic dysfunction (HD). MethodsAdvanced cancer patients were stratified into 4 HD groups based on Organ Dysfunction Working Group hepatic function stratification criteria: normal (Norm), mild (Mild), moderate (Mod), severe (Sev). Dose escalation was based on “3+3” design within each HD group. PK samples were collected at cycle 1 days 15-16. ResultsForty-six patients were enrolled with 44 evaluable for safety [Norm=17, Mild=7, Mod (1.5mg)=4, Mod (2mg)=5, Sev (1mg)=9, Sev (1.5mg)=2] and 22 for PK analysis. Treatment related adverse events were consistent with prior trametinib studies. No treatment related deaths occurred. Dose limiting toxicities (DLTs) were evaluable in 15 patients (Mild=6, Mod (1.5mg)=3, Mod (2mg)=2, Sev (1mg)=3 and Sev (1.5mg)=1). One DLT (grade 3 acneiform rash) was observed in a Sev patient (1.5mg). Dose interruptions or reductions due to treatment related adverse events occurred in 15 patients (34%) [Norm=9, 53%; Mild=2, 29%; Mod (1.5mg)=1, 33%; Mod (2mg)=2, 33%; Sev (1mg)=1, 11%; Sev (1.5mg)=1; 50%]. There were no significant differences across HD groups for all PK parameters when trametinib was normalized to 2 mg. However, only limited PK data were available for the Mod (n=3) and Sev (n=3) groups compared to Norm (n=10) and Mild (n=6) groups. Trametinib is heavily protein bound, with no correlation between serum albumin level and unbound trametinib fraction (p=0.26). ConclusionRP2D for trametinib in Mild HD patients is 2 mg QD. There are insufficient number of evaluable patients due to difficulty of patient accrual to declare RP2D and MTD for Mod and Sev HD groups. DLTs were not observed in the highest dose cohorts that reached three evaluable patients – 1.5 mg QD in Mod group, and 1 mg QD in Sev group. Trial registrationThis study was registered in the ClinicalTrials.gov website (NCT 02070549) on February 25, 2014. https://clinicaltrials.gov/ct2/show/NCT02070549NCI
Gut Microbial Dysbiosis is Correlated with Stroke Severity Markers in Aged Rats Following Stroke
Authors: Hammond Tyler C. , Messmer Sarah , Frank Jaqueline A. , Lukins Douglas , Colwell Rita , Lin Ai-Ling , Pennypacker Keith 
Published: November 2021

Abstract
Background: An imbalanced gut microbial community, or dysbiosis, has been shown to occur following stroke. It is possible that this dysbiosis negatively impacts stroke recovery and rehabilitation. Species level resolution measurements of the gut microbiome following stroke are needed to develop and test precision interventions such as probiotic or fecal microbiota transplant therapies that target the gut microbiome following stroke. Previous studies have used 16S rRNA amplicon sequencing in young male mice to obtain broad profiling of the gut microbiome at the genus level following stroke, but further investigations will be needed with whole genome shotgun sequencing in aged rats of both sexes to obtain species level resolution in a model which will better translate to the demographics of human stroke patients.Results: 39 aged male and female rats underwent middle cerebral artery occlusion. Fecal samples were collected before stroke and three days post stroke to measure gut microbiome. Machine learning was used to identify the top ranked bacteria which were changed following stroke. MRI imaging was used to obtain infarct and edema size and cerebral blood flow (CBF). ELISA was used to obtain inflammatory markers. Dysbiosis was demonstrated by an increase in pathogenic bacteria such as Butyricimonas virosa (15.52 fold change, p<0.0001), Bacteroides vulgatus (7.36 fold change, p<0.0001), and Escherichia coli (47.67 fold change, p<0.0001). These bacteria were positively associated with infarct and edema size and with the inflammatory markers Ccl19, Ccl24, IL17a, IL3, and complement C5; they were negatively correlated with CBF. Conversely, beneficial bacteria such as Ruminococcus flavefaciens (0.14 fold change, p<0.0001), Akkermansia muciniphila (0.78 fold change, p<0.0001), and Lactobacillus murinus (0.40 fold change, p<0.0001) were decreased following stroke and associated with all the previous parameters in the opposite direction of the pathogenic species. There were not significant microbiome differences between the sexes.Conclusion: The species level resolution measurements found here can be used as a foundation to develop and test precision interventions targeting the gut microbiome following stroke. Probiotics that include Ruminococcus flavefaciens, Akkermansia muciniphila, and Lactobacillus murinus should be developed to target the deficit following stroke to measure the impact on stroke severity.