bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical recovery of COVID‐19 pneumosepsis intensive care survivors compared with non‐COVID pneumosepsis intensive care survivors during post–intensive care hospitalization: The RECOVID retrospective cohort study
Authors: Moonen Hanneke Pierre Franciscus Xaverius , Strookappe Bert , van Zanten Arthur Raymond Hubert 
Published: August 2021

AbstractBackgroundCoronavirusdisease 2019 (COVID‐19) pneumosepsis survivors are at a high risk of developing intensive care unit (ICU)–acquired weakness (ICUAW) because of high incidence of acute respiratory distress syndrome and the common need for prolonged invasive ventilation. It remains unknown whether regular postpneumosepsis physical rehabilitation strategies are suitable for this extraordinary patient category.MethodsWe retrospectively compared the physical recovery of COVID‐19 and non‐COVID pneumosepsis ICU survivors during post‐ICU hospitalization, defined as the difference in performance on the Medical Research Council Sum‐Score (MRC‐SS), Chelsea Critical Care Physical Assessment tool (CPAx), and percentage of predicted handgrip strength (POP‐HGS). An analysis of covariance model was built using age, sex, Barthel index, body mass index, admission Acute Physiology And Chronic Health Evaluation II score, adequacy of protein delivery during ICU stay, and ward length of stay as covariates.ResultsThirty‐five COVID‐19 ICU patients could be compared with 21 non‐COVID pneumosepsis ICU survivors. All patients scored ≤48 on the MRC‐SS at ICU discharge, indicating ICUAW. When controlling for covariates, COVID‐19 patients performed worse on all physical assessments upon ICU discharge, but had improved more at hospital discharge on the MRC‐SS (ɳ2 = 0.214, P =.002) and CPAx (ɳ2 = 0.153, P =.011). POP‐HGS remained lower in COVID‐19 patients throughout hospital stay.ConclusionCOVID‐19 ICU survivors are vulnerable to ICUAW, but they show better tendency towards physical rehabilitation than non‐COVID pneumosepsis ICU survivors during the post‐ICU hospitalization period regarding MRC‐SS and CPAx. COVID‐19 ICU patients might benefit from early, more intensive physical therapy.
LAGOS‐US LOCUS v1.0: Data module of location, identifiers, and physical characteristics of lakes and their watersheds in the conterminous U.S.
Authors: Cheruvelil Kendra Spence , Soranno Patricia A. , McCullough Ian M. , Webster Katherine E. , Rodriguez Lauren K. , Smith Nicole J. 
Published: August 2021

AbstractMacroscale studies of aquatic ecosystems are needed to address many contemporary broad‐scale problems related to global change, particularly to inform national‐scale environmental policies. In this data paper, we fill two important gaps in data availability for lakes at the scale of the conterminous U.S., the lack of: (1) high‐resolution geographic representations of lakes and their watersheds and (2) an open data platform to connect disparate U.S. national‐scale lake datasets. We describe the LAGOS‐US LOCUS v1.0 data module that includes a detailed User Guide, which is part of the LAGOS‐US extensible research‐ready open data platform. This platform can be used to study the 479,950 lakes and reservoirs larger than or equal to 1 ha across the entire conterminous U.S. at multiple scales of space and time. The LOCUS module includes spatially‐explicit information on lakes and their watersheds, including location information, physical characteristics, and identifiers of other important national‐scale datasets.
Analysis of the corrosion failure causes of shale gas surface pipelines
Authors: Wu Hua , Huang Chencheng , Wen Ninghua , Mao Ting , Tao Shiping , Wang Maomao 
Published: August 2021

AbstractA shale gas gathering and transportation pipeline in a good block in Sichuan Province started leaking after less than a year of operation. To investigate the causes of corrosion of the sulfate‐reducing bacteria (SRB), optical microscopy, scanning electron microscopy, and X‐ray diffraction were used to analyze the corrosion and perforation of the shale gas surface pipeline in conjunction with bacterial corrosion simulation experiments. The results showed that the pipeline material (L360N) conformed to the requirements of the American Petroleum Institute 5 L standard and that extracellular polymeric substances were present in the corrosion pits. The corrosion products mainly included FeCO3, FeS, CaCO3, MgCO3, and Fe mineralization. At 40°C, the uniform corrosion rate of L360N in the simulation experiment was 0.234 mm/a, and the local corrosion rate was 0.458 mm/a. SRB, saprophytes, and iron bacteria were detected in the on‐site water medium and corrosion products, indicating that the main causes of shale gas pipeline corrosion are bacterial and CO2 corrosion.
Investigation and modelling of edge corrosion of e‐coated galvanized steel with respect to the spatial edge orientation
Authors: Kapfer Konstantin , Mandel Marcel , Mittelbach Andreas , Krüger Lutz 
Published: August 2021

AbstractThe effect of the spatial orientation of e‐coated hot dip galvanized test sheets on edge corrosion is investigated. Therefore paint delamination from corrosion sample edges at different steps in time of samples at different angles relative to the horizontal during a corrosion test is analysed. Two general relations are found: Horizontally oriented edges exhibit significantly increased coating delamination compared with vertically oriented edges. This is due to increased exposure to the electrolyte, resulting from the pinning of electrolyte droplets along the upper edge. With increasing angular displacement relative to the ground, electrolyte exposure and edge delamination decrease. The edges of the upward‐facing specimen side showed a higher delamination width compared with the downward‐facing side at the same angle. These results are supported by electrochemical impedance spectroscopy and a wetting test. Ultimately, a semi‐empirical model to numerically predict the edge delamination over time, incorporating electrochemical impedance spectroscopy and polarization curves, is presented.
Morin Acts as a USP7 Inhibitor to Hold Back the Migration of Rheumatoid Arthritis Fibroblast‐Like Synoviocytes in a “Prickle1‐mTORC2” Dependent Manner
Authors: Yang Ling , Cao Na , Miao Yumeng , Dai Yue , Wei Zhifeng 
Published: July 2021

IntroductionThe aim of this study is to investigate the effect and detailed mechanisms of morin, an anti‐arthritis compound widely distributed in foods of plant origin, on the pathological migration of fibroblast‐like synoviocytes (FLS).Methods and ResultsThe migration of FLS collected from arthritis rats and MH7A cells is induced by platelet‐derived growth factor, and an arthritis model in rats is established by Freund's complete adjuvant. The results show that morin remarkably restrains FLS migration but slightly affects FLS apoptosis and proliferation. Moreover, in the progression of FLS migration, focal adhesion (FA) turnover is inhibited by morin via lowering the activation of Paxillin and focal adhesion kinase (FAK) and internalization of integrin β1. Morin disrupts the formation of mTOR complex 2 (mTORC2) and the activation of AKT (S473) and PKCα (S657), and MHY1485 reverses morin‐limited FLS migration. Of note, the protein stability of Prickle1, a binding factor of Rictor, is reduced by morin, and MG132 but not Baf A1 shows a repressive effect. Finally, the target protein is identified as ubiquitin‐specific protease 7 (USP7) but not USP9X. USP7 overexpressing plasmid weakens morin‐affected protein and ubiquitination of Prickle1, and mechanisms are confirmed in vivo by using an overexpressing plasmid and inhibitor.ConclusionMorin restricts FLS migration and arthritis by intervening in “USP7‐Prickle1‐mTORC2” signaling and FA turnover.
Procyanidin B1 and p‐Coumaric Acid from Highland Barley Grain Showed Synergistic Effect on Modulating Glucose Metabolism via IRS‐1/PI3K/Akt Pathway
Authors: Liu Ze‐Hua , Li Bo 
Published: August 2021

IntroductionPhenolic extract in highland barley grain has showed hypoglycemic effect, while little information is available about the active compounds and whether there exist additive or synergistic effect on modulating glucose metabolism.Methods and ResultsProcyanidin B1 (PB) and p‐coumaric acid (CA) are the active compounds in highland barley grain and show synergistic effect on improving glucose uptake and glycogen synthesis by upregulating glucose transporter (GLUT4) and downregulating glycogen synthase kinase‐3β (GSK‐3β) protein expression, respectively. The mechanism may be attributed to target insulin receptor (IRβ) and regulate insulin receptor substrate‐1 (IRS‐1)/phosphatidylinositol 3‐kinase (PI3K)/ protein kinase B (Akt) pathway. Furthermore, PB + CA exhibits synergistic effect on restoring glucose intolerance and insulin resistance, and improving hepatic glycogen synthesis in impaired glucose tolerance (IGT) mice. The postprandial blood glucose (PBG), homeostasis model assessment (HOMA)‐IR values and serum insulin contents in PB + CA‐treated IGT mice with dosage of 300 mg kg‐1 BW are reversed to normal levels. Additionally, PC + CA shows additive effect on inhibiting gluconeogenesis in vitro and in vivo.ConclusionPB + CA in highland barley grain synergistically modulate glucose metabolism. These results may provide evidence of whole highland barley grain diet achieve superior effect on restoring IGT than isolated components.
A novel use of biomechanical model‐based deformable image registration (DIR) for assessing colorectal liver metastases ablation outcomes
Authors: Anderson Brian M. , Lin Yuan‐Mao , Lin Ethan Y. , Cazoulat Guillaume , Gupta Sanjay , Kyle Jones A. , Odisio Bruno C. , Brock Kristy K. 
Published: August 2021

AbstractPurposeColorectal cancer is the third most common form of cancer in the United States, and up to 60% of these patients develop liver metastasis. While hepatic resection is the curative treatment of choice, only 20% of patients are candidates at the time of diagnosis. While percutaneous thermal ablation (PTA) has demonstrated 24%–51% overall 5‐year survival rates, assurance of sufficient ablation margin delivery (5 mm) can be challenging, with current methods of 2D distance measurement not ensuring 3D minimum margin. We hypothesized that biomechanical model‐based deformable image registration (DIR) can reduce spatial uncertainties and differentiate local tumor progression (LTP) patients from LTP‐free patients.MethodsWe retrospectively acquired 30 patients (16 LTP and 14 LTP‐free) at our institution who had undergone PTA and had a contrast‐enhanced pre‐treatment and post‐ablation CT scan. Liver, disease, and ablation zone were manually segmented. Biomechanical model‐based DIR between the pre‐treatment and post‐ablation CT mapped the gross tumor volume onto the ablation zone and measured 3D minimum delivered margin (MDM). An in‐house cone‐tracing algorithm determined if progression qualitatively collocated with insufficient 5 mm margin achieved.ResultsMann–Whitney U test showed a significant difference (p < 0.01) in MDM from the LTP and LTP‐free groups. A total of 93% (13/14) of patients with LTP had a correlation between progression and missing 5 mm of margin volume.ConclusionsBiomechanical DIR is able to reduce spatial uncertainty and allow measurement of delivered 3D MDM. This minimum margin can help ensure sufficient ablation delivery, and our workflow can provide valuable information in a clinically useful timeframe.
Weight Loss, Survival, and Fatty Acid Composition in Overwintered Juvenile Coppernose Bluegill Lepomis macrochirus purpurescens Cultured in Outdoor Tanks Using Different Feeding Regimens
Authors: Roy Luke A. , Rawles Steven D. , Quintero Herbert E. , Kelly Anita M. , Park Jeonghwan , Webster Carl D. 
Published: August 2021

Abstract
Commercial producers raising centrarchids in Arkansas routinely report winter mortality. Juvenile centrarchids are susceptible to harsh winter conditions. The Coppernose Bluegill Lepomis macrochirus purpurescens is a popular sport fish for recreational fishing, and there are no recommended best management practices for winter feeding of this species. An outdoor trial was conducted to investigate the effect of different feeding regimens on performance of Coppernose Bluegill in the winter of 2014–2015. Four feeding regimens were implemented that included feeding twice per week (2×/week), once per week (1×/week), twice per month (2×/month), or once per month (1×/month). Twenty-five Coppernose Bluegill (initial weight = 2.59 ± 0.19 g) were stocked per tank (16 tanks, 4 replicates). Temperatures ranged from 0°C to 16°C during the trial. After 95 d, there were no differences (P &gt; 0.05) in final weight or weight loss. Fish that were fed 2×/week or 1×/week had higher survival (P &lt; 0.05) than those fed 2×/month or 1×/month. Fatty acid profiles of initial fish were distinctly different from the postwinter profiles of fed fish, although winter feeding frequency did not appear to influence fatty acid profiles in Coppernose Bluegill. Levels of saturates were higher in initial fish than in postwinter fish. The monounsaturated fatty acids 16:1 and 18:1(n-9) were higher in initial fish than in postwinter fish. Initial fish contained lower levels of 18:2(n-6), 20:4, and 22:6(n-3) than postwinter fish. Total polyunsaturated fatty acids (PUFAs) and n-3 and n-6 levels were also lower in initial fish than in postwinter fish, while the ratio of n-6/n-3 fatty acids did not differ significantly among initial and postwinter fed fish. Data indicate that (1) overwintering and infrequently fed Coppernose Bluegill preferentially conserve PUFAs and (2) feeding 1 × /week or 2 × /week may be a beneficial strategy for sport fish producers to increase survival of Coppernose Bluegill during the winter in temperate regions of the USA.
Predicting the return of bladder function following vaginal native tissue repair using data from a suprapubic catheter regimen
Authors: Hines Katherine N. , McKenzie Collin , Overholt Tyler , Mirzazadeh Majid , Matthews Catherine A. , Schachar Jeffrey , Russel Greg , Lentz Samuel 
Published: August 2021

AbstractAimsTo evaluate time to return of normal voiding function following native tissue vaginal reconstruction and evaluate risk factors for postoperative urinary retention (POUR).MethodsA retrospective cohort analysis of women undergoing vaginal reconstruction and suprapubic catheter with standardized regimen for voiding trials. Postvoid residual <150 ml at 4 h post catheter clamping was used as surrogate marker for return of bladder function. Univariate and multivariate regression analyses were used to identify risk factors for return of bladder function >4 days after surgery.ResultsBetween 2013 and 2018, 148 women underwent surgery, 124 were analyzed. Mean age was 67 years (±11.1), 62.9% (n = 78) had greater than or equal to stage 3 prolapse. Mean time to return of bladder function: 4.1 days (±3.1). Significant risk factors for >4 days to return of bladder function on univariate analysis included (mean ± SD): surgery length (150.4 min ±44.6) (odds ratio [OR], 1.24; confidence interval [CI], 1.12, 1.38); anesthesia length (228.1 min ±53.5) (OR, 1.12; CI: 1.04, 1.23); length of stay (2.2 days ±2.7) (OR, 2.43; CI: 1.11, 5.35); hysterectomy (OR, 3.10; CI: 1.39, 6.90); estimated blood loss (124.4 ml ±64.8) (OR, 1.39; CI: 1.04, 1.87). Postmenopausal status was protective (OR, 0.17; CI: 0.03, 0.92.). On multivariate analysis, significant findings were diabetes mellitus (OR, 0.18; CI: 0.04, 0.93) and surgery length (OR, 1.21; CI: 1.06, 1.38).ConclusionsHysterectomy, surgical length and estimated blood loss were significantly associated with delayed return of bladder function after native tissue vaginal reconstruction. This data can help clinicians tailor postoperative voiding trials after failed initial attempt.
Nebulized plasma‐activated water has an effective antimicrobial effect on medically relevant microbial species and maintains its physicochemical properties in tube lengths from 0.1 up to 1.0 m
Authors: Chiappim William , Sampaio Aline , Miranda Felipe , Petraconi Gilberto , da Silva Sobrinho Argemiro , Cardoso Paulo , Kostov Konstantin , Koga‐Ito Cristiane , Pessoa Rodrigo 
Published: August 2021

AbstractThis study applies a proof of concept for future applications in controlling the microbiota in tubes and tracheal appliances used in the respiratory tract. Therefore, the physical–chemical parameters of the plasma‐activated and nebulized water (NPAW) are measured in a nebulizer tube with different lengths between 0.1 and 3.0 m. The pH values and oxidation–reduction potential (ORP) do not change during nebulization of PAW over a 1.0 m tube. However, for longer lengths, there is an increase in pH and a decrease in ORP. At 3.0 m, the pH increases approximately 16% compared with the 1.0 m position with a 20% decrease in the ORP values. Hydrogen peroxide (H2O2) measured quantitatively using test strips presents values between 0.5 and 2.0 mg/L for condensed NPAW in different tube lengths between 0.1 and 3.0 m, and maintains the approximate value of 2.0 mg/L in tubes up to 1.0 m, with a reduction proportional to the increase in the length of the tube. The antimicrobial efficacy of NPAW applied for 15 min shows the inactivation of Staphylococcus aureus and Escherichia coli but without significant inactivation of Candida albicans.
Cyclic etching of silicon oxide using NF3/H2 remote plasma and NH3 gas flow
Authors: Gill You Jung , Kim Doo San , Gil Hong Seong , Kim Ki Hyun , Jang Yun Jong , Kim Ye Eun , Yeom Geun Young 
Published: August 2021

AbstractSelective isotropic cyclic dry etching of silicon oxide (SiO2) was investigated using a three‐step cyclic process composed of hydrogen fluoride (HF) adsorption by NF3/H2 remote plasma and reaction with NH3 gas flow to form ammonium fluorosilicate ((NH4)2SiF6), and desorption by heating. The variation of the ratio of NF3:H2 (2:1 to 1:3) and adsorption time (10–180 s) showed the highest etch selectivity of SiO2 over Si3N4 at 1:2 ratio of NF3:H2 and with the adsorption time of 20 s. The etch selectivity higher than 40 was observed with 20 s of adsorption time with a 1:2 ratio of NF3:H2 remote plasma and the total etch depth was linearly increased with the increase of cycles with the SiO2 EPC of ~7.5 nm/cycle.
Flexible parametric copula modeling approaches for clustered survival data
Authors: Kwon Sookhee , Ha Il Do , Shih Jia‐Han , Emura Takeshi 
Published: August 2021

AbstractCopula‐based survival regression models, which consist of a copula function and marginal distribution (i.e., marginal survival function), have been widely used for analyzing clustered multivariate survival data. Archimedean copula functions are useful for modeling such dependence. For the likelihood inference, one‐stage and two‐stage estimation methods have been usually used. The two‐stage procedure can give inefficient estimation results because of separate estimation of the marginal and copula's dependence parameters. The more efficient one‐stage procedure has been mainly developed under a restrictive parametric assumption of marginal distribution due to complexity of the full likelihood with unknown marginal baseline hazard functions. In this paper, we propose a flexible parametric Archimedean copula modeling approach using a one‐stage likelihood procedure. In order to reduce the complexity of the full likelihood, the unknown marginal baseline hazards are modeled based on a cubic M‐spline basis function that does not require a specific parametric form. Simulation results demonstrate that the proposed one‐stage estimation method gives a consistent estimator and also provides more efficient results over existing one‐ and two‐stage methods. The new method is illustrated with three clinical data sets. The Appendix provides an R function so that the proposed method becomes directly accessible to interested readers.
Confidence intervals for exposure‐adjusted rate differences in randomized trials
Authors: Scosyrev Emil , Pethe Abhijit 
Published: August 2021

AbstractExposure‐adjusted event rate is a quantity often used in clinical trials to describe average event count per unit of person‐time. The event count may represent the number of patients experiencing first (incident) event episode, or the total number of event episodes, including recurring events. For inference about difference in the exposure‐adjusted rates between interventions, many methods of interval estimation rely on the assumption of Poisson distribution for the event counts. These intervals may suffer from substantial undercoverage both, asymptotically due to extra‐Poisson variation, and in the settings with rare events even when the Poisson assumption is satisfied. We review asymptotically robust methods of interval estimation for the rate difference that do not depend on distributional assumptions for the event counts, and propose a modification of one of these methods. The new interval estimator has asymptotically nominal coverage for the rate difference with an arbitrary distribution of event counts, and good finite sample properties, avoiding substantial undercoverage with small samples, rare events, or over‐dispersed data. The proposed method can handle covariate adjustment and can be implemented with commonly available software. The method is illustrated using real data on adverse events in a clinical trial.
Transplantation of Human Autologous Synovial Mesenchymal Stem Cells with Trisomy 7 into the Knee Joint and 5 Years of Follow-up
Authors: Mizuno Mitsuru , Endo Kentaro , Katano Hisako , Amano Naoki , Nomura Masaki , Hasegawa Yoshinori , Ozeki Nobutake , Koga Hideyuki , Takasu Naoko , Ohara Osamu , Morio Tomohiro , Sekiya Ichiro 
Published: August 2021

AbstractMesenchymal stem cells (MSCs) can show trisomy 7; however, the safety of these cells has not been fully investigated. The purposes of this study were to determine the ratio of patients whose synovial MSCs were transplanted clinically, to intensively investigate MSCs with trisomy 7 from a safety perspective, and to follow up the patients for 5 years after transplantation. Synovial MSCs at passage 0 were transplanted into a knee for degenerative meniscus tears in 10 patients, and the patients were checked at 5 years. The synovial MSCs were evaluated at passages 0 to 15 by G-bands and digital karyotyping, and trisomy 7 was found in 3 of 10 patients. In those three patients, 5% to 10% of the synovial MSCs showed trisomy 7. The mRNA expressions of representative oncogenes and genes on chromosome 7 did not differ between MSCs with and without trisomy 7. Whole-genome sequencing and DNA methylation analysis showed similar results for MSCs with and without trisomy 7. Transplantation of human synovial MSCs with trisomy 7 into eight mouse knees did not result in tumor formation under the skin or in the knees after 8 weeks in any mouse, whereas transplanted HT1080 cells formed tumors. In vitro chondrogenic potentials were similar between MSCs with and without trisomy 7. Five-year follow-ups revealed no serious adverse events in all 10 human patients, including 3 who had received MSCs with trisomy 7. Overall, our findings indicated that synovial MSCs with trisomy 7 were comparable with MSCs without trisomy 7 from a safety perspective.