bluuebunny/crossref_metadata_2025_split huggingface dataset:
TOI-1634 b: An Ultra-short-period Keystone Planet Sitting inside the M-dwarf Radius Valley
Authors: Cloutier Ryan , Charbonneau David , Stassun Keivan G. , Murgas Felipe , Mortier Annelies , Massey Robert , Lissauer Jack J. , Latham David W. , Irwin Jonathan , Haywood Raphaëlle D. , Guerra Pere , Girardin Eric , Giacalone Steven A. , Bosch-Cabot Pau , Bieryla Allyson , Winn Joshua , Watson Christopher A. , Vanderspek Roland , Udry Stéphane , Tamura Motohide , Sozzetti Alessandro , Shporer Avi , Ségransan Damien , Seager Sara , Savel Arjun B. , Sasselov Dimitar , Rose Mark , Ricker George , Rice Ken , Quintana Elisa V. , Quinn Samuel N. , Piotto Giampaolo , Phillips David , Pepe Francesco , Pedani Marco , Parviainen Hannu , Palle Enric , Narita Norio , Molinari Emilio , Micela Giuseppina , McDermott Scott , Mayor Michel , Matson Rachel A. , Martinez Fiorenzano Aldo F. , Lovis Christophe , López-Morales Mercedes , Kusakabe Nobuhiko , Jensen Eric L. N. , Jenkins Jon M. , Huang Chelsea X. , Howell Steve B. , Harutyunyan Avet , Fűrész Gábor , Fukui Akihiko , Esquerdo Gilbert A. , Esparza-Borges Emma , Dumusque Xavier , Dressing Courtney D. , Fabrizio Luca Di , Collins Karen A. , Cameron Andrew Collier , Christiansen Jessie L. , Cecconi Massimo , Buchhave Lars A. , Boschin Walter , Andreuzzi Gloria 
Published: July 2021

Abstract
Studies of close-in planets orbiting M dwarfs have suggested that the M-dwarf radius valley may be well explained by distinct formation timescales between enveloped terrestrials and rocky planets that form at late times in a gas-depleted environment. This scenario is at odds with the picture that close-in rocky planets form with a primordial gaseous envelope that is subsequently stripped away by some thermally driven mass-loss process. These two physical scenarios make unique predictions of the rocky/enveloped transition’s dependence on orbital separation such that studying the compositions of planets within the M-dwarf radius valley may be able to establish the dominant physics. Here, we present the discovery of one such keystone planet: the ultra-short-period planet TOI-1634 b (P = 0.989 days,

F
=
121

F

⊕

,

r

p

=

1.790

−
0.081

+
0.080

R
⊕) orbiting a nearby M2 dwarf (K

s
= 8.7, R

s
= 0.450 R
⊙, M

s
= 0.502 M
⊙) and whose size and orbital period sit within the M-dwarf radius valley. We confirm the TESS-discovered planet candidate using extensive ground-based follow-up campaigns, including a set of 32 precise radial velocity measurements from HARPS-N. We measure a planetary mass of

4.91

−
0.70

+
0.68

M
⊕, which makes TOI-1634 b inconsistent with an Earth-like composition at

5.9
σ

and thus requires either an extended gaseous envelope, a large volatile-rich layer, or a rocky composition that is not dominated by iron and silicates to explain its mass and radius. The discovery that the bulk composition of TOI-1634 b is inconsistent with that of Earth supports the gas-depleted formation mechanism to explain the emergence of the radius valley around M dwarfs with

M

s

≲
0.5

M
⊙.
Model-independent Estimation of H
0 and Ω
K
from Strongly Lensed Fast Radio Bursts
Authors: Zhao Shaoxin , Liu Bin , Li Zhengxiang , Gao He 
Published: July 2021

Abstract
Model-independent estimation of H
0 and Ω
K
can provide clues about the origin of the intractable Hubble constant tension and the current cosmic-curvature crisis. Strongly lensed fast radio bursts (FRBs) have been proposed as precision probes of the universe since the time delay ∼



(10 days) between images could be precisely measured due to short durations ∼


(
ms
)

of this kind of bright radio pulses. Here, on the basis of the distance sum rule, we investigate the capacity of model-independently estimating these two parameters from time-delay distances of strongly lensed FRBs and luminosity distances of the upcoming Wide Field InfraRed Survey Telescope (WFIRST) type Ia supernovae observations. Considering the expected FRB detection rate of upcoming facilities, we find that H
0 could be determined to a ∼1% precision and Ω
K
could be constrained to ∼0.1 simultaneously from 10 lensed FRBs. These estimations, which are independent of the energy contents of the universe and validity of Einstein’s equation on cosmological scales, will be complementary to popular probes and of great importance for clarifying the current crises of cosmology.
Fluvial Features on Titan and Earth: Lessons from Planform Images in Low-resolution SAR
Authors: Miller J. W. , Birch S. P. D. , Hayes A. G. , Malaska M. J. , Lopes R. M. C. , Schoenfeld A. M. , Corlies P. M. , Burr D. M. , Farr T. G. , Perron JT 
Published: July 2021

Abstract
Cassini Synthetic Aperture Radar (SAR) images of Titan’s surface revealed river networks strikingly similar to those on Earth. However, Cassini SAR has low spatial resolution and image quality compared to data used to map channels on Earth, so traditional methods for characterizing river networks might not yield accurate results on Titan. We mapped terrestrial analog networks with varying resolutions and image qualities to determine which geomorphologic metrics were invariant with scale or resolution. We found that branching angle and drainage density varied significantly with image resolution, and we therefore expect the actual drainage density of Titan’s channel networks to be significantly higher than the values calculated from Cassini data. Calculated network geometry did not change predictably with resolution and would therefore not be an ideal metric for interpreting Titan’s channel networks. The measured channel width, basin length and width, and drainage area all behaved predictably as resolution varied, leading us to conclude that these metrics could be applied to Cassini data. We then mapped all observable fluvial features on Titan—excluding those in the highly incised labyrinth terrains—visible in the Cassini data set. In our new maps, we observe differences in basin shapes between Titan’s polar and equatorial regions and dichotomies in the relative channel density between the northern and southern midlatitudes and poles of Titan: channels are concentrated at the poles and southern midlatitudes. These patterns may reflect differences in bedrock material and/or different climate histories.
The Geographic Distribution of Dense-phase O2 on Ganymede
Authors: Trumbo Samantha K. , Brown Michael E. , Adams Danica 
Published: July 2021

Abstract
Ground-based spectroscopy of Ganymede’s surface has revealed the surprising presence of dense-phase molecular oxygen (O2) via weak absorptions at visible wavelengths. To date, the state and stability of this O2 at the temperatures and pressures of Ganymede’s surface are not understood. Its spatial distribution in relation to albedo, expected temperatures, particle irradiation patterns, or composition may provide clues to these unknowns. We present spatially resolved observations of Ganymede’s surface O2 obtained with the Hubble Space Telescope and construct the first comprehensive map of its geography. In agreement with the limited spatially resolved data published previously, our map suggests that the condensed O2 is concentrated at the low to midlatitudes of the trailing hemisphere, a distribution that may reflect influences of Ganymede’s intrinsic magnetic field on the bombardment of its surface by Jovian magnetospheric particles. Overlapping regions from different observations within this data set also show evidence for moderate temporal variability in the surface O2, but we are unable to distinguish between potential causes with the available data.
Monilochaetes pteridophytophila (Australiascaceae, Glomerellales), a new fungus from tree fern
Authors: Zhang Jingyi , Phookamsak Rungtiwa , Mapook Ausana , Lu Yongzhong , Lv Menglan 
Published: July 2021

During taxonomic and phylogenetic studies of fungi on pteridophytes in Thailand, Monilochaetes pteridophytophila sp. nov. was collected from the frond stalks of a tree fern (Alsophila costularis, Cyatheaceae). The new species is introduced, based on evidence from morphology and phylogenetic analyses of a concatenated dataset of LSU, ITS, SSU and RPB2 sequences.
Monilochaetes pteridophytophila differs from extant species of Monilochaetes in having darker conidiophores with fewer septae (1–4-septate). Monilochaetes pteridophytophila forms a distinct clade, basal from other species of Monilochaetes in Australiascaceae. A detailed description and illustrations of the new species are provided. We also provided a synopsis of accepted species of Monilochaetes.
Mobi-Cité Seniors, la médiation sociale au service de la mobilité des personnes âgées
Authors: Lardin Clélia 
Published: July 2021

Ne pouvant pas sortir facilement et ainsi accéder aux commerces et services du quotidien, de nombreuses personnes âgées se replient sur elles-mêmes. Depuis septembre 2012, en lien avec ses partenaires de la ville de Bron, la régie de quartier a développé un service de proximité pour lutter contre l’isolement des personnes âgées du territoire. « Mobi-Cité Seniors » est porté par une équipe de médiateurs en contrat d’adultes-relais, sous la responsabilité de la coordinatrice du pôle médiation, Clélia Lardin.
Accompagner le maintien à domicile : le rôle clé des bailleurs
Authors: Bahloul Siham , Deloche Xavier , Molina Cruz Séverine 
Published: July 2021

Adaptation des logements, construction de résidences seniors, projets intergénérationnels, formation et sensibilisation des personnels… l’éventail des actions conduites par les bailleurs en faveur du maintien à domicile des personnes âgées est très large, comme en témoignent les expériences présentées par trois bailleurs : Montluçon Habitat, Lyon Métropole Habitat et GrandLyon Habitat.
Traduire politiquement le soulèvement de mai 2021 : les défis du mouvement national palestinien
Authors: Dot-Pouillard Nicolas 
Published: July 2021

Dans les rapports de force inter-palestiniens, le Hamas est sorti renforcé du soulèvement de mai 2021 et de la guerre à Gaza. Le Fatah, quant à lui, est miné par des divisions internes. Il hésite entre un retour à l’Intifada et la seule défense de l’Autorité nationale palestinienne. Réforme de l’Organisation de libération de la Palestine (OLP), élections, renouvèlement du leadership palestinien, réconciliation inter-palestinienne : le mouvement national palestinien est à un tournant. Dans ce contexte, les divisions inter-palestiniennes priment toujours et le soulèvement de mai 2021 ne trouve pas encore de traduction politique.
La Blockchain, un outil innovant au service du financement des entreprises
Authors: Alfieri Elise , Burlacu Radu , Enjolras Geoffroy 
Published: July 2021

Le financement des entreprises bénéficie de l’introduction de techniques et solutions innovantes fondées sur la technologie blockchain. Afin de les analyser, cet article propose un cadre théorique centré sur les risques : les mécanismes de marché, les asymétries d’information, l’opportunisme, les garanties juridiques et les risques opérationnels. A partir d’une analyse de la littérature, nous développons une typologie des modes de financement en nous appuyant sur deux dimensions : les moyens d’échange et les contrats. Une étude de quatre situations appuie cette classification et démontre le potentiel de la blockchain en dépit de l’apparition de nouveaux risques.
Le management du capital humain dans le cadre d’une approche de développement organisationnel : étude de cas dans le secteur médico-social
Authors: Goujon Belghit Anne , Cuénoud Thibault , Bretonès Daniel , Cherrad Othmane 
Published: July 2021

Le management du capital humain ouvre une nouvelle piste pour améliorer la performance globale des organisations dans la mesure où la démarche est multipartite. L’étude de cas « Solincité » offre un contexte d’analyse intéressant pour plusieurs raisons. Tout d’abord, il s’agit du secteur social et médico-social, aux contraintes et règles de fonctionnement bien spécifiques. Ensuite, le cas retrace le parcours d’une intégration de deux établissements pour devenir une seule organisation. Finalement un modèle intégrateur est proposé, soulignant les mises en relation inter-capital humain et les risques associés à ces dynamiques de changement dans une approche de développement organisationnel.
Effective Cytotoxicity of Dendritic Cells against Established T Cell Lymphomas in Mice
Authors: Dubois Sigrid , Waldmann Thomas A , Müller Jürgen R 
Published: July 2021

Abstract
T cell lymphomas arise in mice that constitutively express a single TCR in the absence of NK cells. Upon TCR engagement these lymphomas are able to corrupt tumor surveillance by decreasing NK cell numbers. In this study, we investigate the outcome of interactions between these T cell lymphomas and dendritic cells. Bone marrow–derived dendritic cells mediated effective killing of T cell lymphomas after activation with IFN-γ and TLR ligands in culture. This cytotoxicity was independent of MHC compatibility. Cell lysis was reduced by the presence of the peroxynitrite inhibitors FeTTPS and L-NMMA, whereas inhibitors of apoptosis, death receptors, and degranulation were without effect, suggesting NO metabolites as the main mediators. When injected together with GM-CSF and R848 into lymphoma-bearing mice, in vitro–expanded bone marrow–derived dendritic cells caused significant survival increases. These data show that dendritic cell adaptive immunotherapy can be used as treatment against T cell lymphomas in mice.
Knowledge of the Female Athlete Triad and Relative Energy Deficiency in Sport Among Female Cross-Country Athletes and Support Staff
Authors: Lodge Melissa T. , Ackerman Kathryn E. , Garay Jessica 
Published: July 2021

Context
Female endurance athletes exhibit an increased risk of the female athlete triad (Triad) and relative energy deficiency in sport (RED-S). The triad and RED-S are conditions that involve the health and performance consequences of low energy availability. Few authors of studies to date have assessed the knowledge that athletes, coaches, and athletic trainers (ATs) have regarding the Triad or RED-S. Proper education has been shown to be effective in increasing knowledge of sports medicine concerns for athletes, yet no known continuing education programs for the Triad or RED-S exist at collegiate institutions.

Objective
To assess the knowledge, confidence, and educational impact of identifying, screening, treating, and preventing the Triad or RED-S.

Design
Cross-sectional study.

Setting
An evidence-based online survey was developed and administered via Qualtrics.

Patients or Other Participants
Female collegiate cross-country athletes (n = 275, age = 20 ± 1 years), collegiate cross-country coaches (n = 55, age = 34 ± 9 years), and ATs working with cross-country teams (n = 30, age = 36 ± 11 years).

Main Outcome Measure(s)
Knowledge, confidence, and educational impact scores were assessed among groups using analysis of variance. Independent t tests were calculated to determine differences in impact scores between people who had or had not received education on the topic.

Results
Female cross-country athletes' total knowledge, confidence, and educational impact scores (mean scores = 25.00 ± 5.27, 95.42 ± 28.83, and 18.81 ± 7.05, respectively) were different from those of coaches (mean scores = 26.92 ± 5.02, 111.35 ± 24.14, and 22.41 ± 6.33, respectively) and ATs (mean scores = 28.66 ± 4.02, 117.67 ± 22.53, and 23.93 ± 5.69, respectively; P &lt; .05).

Conclusions
Knowledge, confidence, and educational impact scores regarding Triad or RED-S were lowest in female cross-country athletes and highest in ATs. These findings support the call for education, which should be regarded as the primary tool for increasing knowledge, to improve the prevention and treatment of the Triad or RED-S.
Vitamin D-Binding Protein is Involved in the Pathogenesis of Preeclampsia by Inhibiting the Tyrosine Phosphorylation of Vascular Endothelial Growth Factor Receptor-2 in Endothelial Cells
Authors: Lu Ting-Feng , Ye Yun-Zhen , Li Xiao-Tian , Zhang Ying 
Published: July 2021

Abstract

Objective:
The role of Vitamin D-binding protein (DBP) in preeclampsia (PE) pathogenesis is unknown. In this study, we compared the expression of DBP in the placentas of PE patients with the placentas of normotensive pregnant women with placenta previa controls, and aimed to explore the effect of DBP on endothelial cells (ECs) and the underlying mechanism.

Methods:
DBP expression in placental tissues collected from PE patients and controls was evaluated by immunohistochemistry. The downregulation and upregulation of DBP expression in HTR-8/SVneo cells were examined using DBP-targeting small interfering RNA (siRNA) and DBP-expression vector, respectively. The conditioned media of these DBP-overexpressing and DBP-siRNA HTR-8/SVneo cells were collected and added to human umbilical vein EC (HUVEC) cultures. Angiogenic effects on HUVECs were assessed by tube formation assays, and the proliferation and migration of HUVECs were examined using the Real-Time Cell Analyzer. The expression of vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR)-2, as well as the phosphorylation of different residues of VEGFR-2 in HUVECs, were determined by western blotting.

Results:
DBP expression was significantly increased in the placental tissues collected from PE patients. The conditioned medium of DBP-overexpressing HTR-8/SVneo cells potently inhibited tube formation by HUVECs, in addition to their proliferation and migration. Furthermore, treatment of HUVECs with the conditioned medium of DBP-overexpressing HTR-8/SVneo cells decreased the phosphorylation of VEGFR-2 at tyrosine 996, whereas the treatment of these cells with the conditioned medium of DBP-siRNA HTR-8/SVneo cells increased the phosphorylation of VEGFR-2 at tyrosine 951, 996, and 1,175.

Conclusions:
The expression of DBP is increased in the placentas of PE patients. DBP plays potential roles in endothelial dysfunction, which contributes to PE development, by inhibiting tyrosine phosphorylation of VEGFR-2 in ECs.
Syzygium cumini (jamun) fruit-extracted phytochemicals exert anti-proliferative effect on ovarian cancer cells
Authors: Li Li , Mangali Sureshbabu , Kour Navneet , Dasari Deepika , Ghatage Trupti , Sharma Vikas , Dhar Arti , Bhat Audesh 
Published: July 2021

Background:
The medicinal properties of Syzygium sp., especially the antidiabetic property, date back to the ancient times. However, in the recent past, extracts from different parts of the Syzygium sp. have demonstrated promising anticancer activities in diverse cancer types, and now, attempts are being made to identify the active phytochemicals.

Aims and Objectives:
In this study, we intended to test the anticancer properties of phytochemicals extracted from the fruit of Syzygium cumini plant in ovarian cancer cells.

Materials and Methods:
A total of nine phytochemicals extracted from the S. cumini fruits using chloroform were tested for their anticancer activity in the ovarian cancer cell line PA-1. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide tetrazolium assay was performed to calculate the 50% inhibition (IC50) concentration and cell cytotoxicity values. Cell scratch assay was performed to assess the proliferation inhibition activity of the phytochemicals. Cisplatin was used as positive control.

Results:
Out of the nine phytochemicals tested, quercetin (QC), gallic acid (GA), and oleanolic acid (OA) were found active. QC and GA were most effective with more than 90% cell cytotoxicity at 2.5 µ g/ml and above concentrations and OA moderately effective up to 5 µg/ml serial concentrations. Cell proliferation was significantly inhibited by QC and GA and moderately but significantly by OA.

Conclusion:
Our data demonstrate the anticancer activity of QC, GA, and OA phytochemicals, which is consistent with the previous reports. However, this is the first report showing the anticancer activity of these phytochemicals derived from S. cumini in the ovarian cancer cells. These data suggest that there is a potential to develop these phytochemicals as anticancer therapeutic agents either as monotherapeutic agents or in combination with commonly used chemotherapeutic agents, which needs to be explored.
The predictive value of depth of invasion and tumor size on risk of neck node metastasis in squamous cell carcinoma of the oral cavity
Authors: Jangir Naresh Kumar , Singh Akash , Jain Preeti , Khemka Shruti 
Published: July 2021

Background:
Tumor depth is a reliable parameter to predict nodal metastasis in oral cancers; therefore, the authors embarked upon a prospective observational study to define the relationship between the tumor depth and the risk of cervical lymph node involvement as well to determine the optimal tumor depth cutoff point for nodal metastasis.

Aims:
The aim was to study the predictive value of depth of invasion (DOI) and tumor size on risk of cervical node metastasis in squamous cell carcinoma of the oral cavity.

Materials and Methods:
Biopsy-proven Stage I–Stage III oral cavity squamous cell carcinoma patients were included in this prospective, observational study. Various histopathological characteristics (DOI, tumor size, lympho-vascular invasion [LVI], perineural spread, and grade of differentiation) were analyzed to predict the cervical node metastasis.

Statistical Analysis Used:
The impact of the clinical and histopathological parameters of primary tumor on cervical lymph node metastasis was analyzed by univariate as well as multivariate logistic regression analyses using NCSS 12 version 12.0.5 statistical software.

Results:
The independent predictors of cervical lymph node metastasis were DOI (P = 0.0014) and LVI (P = 0.0414). The incidence of cervical metastasis increased markedly when the DOI was over 5 mm, and it was a statistically significant (P < 0001) association.

Conclusions:
DOI is a significant predictor of cervical nodal metastasis and tumor depth 5 mm can be considered as a cutoff value in staging and management of early oral squamous cell carcinoma.
Gaming Pattern, Prevalence of Problematic Gaming, and Perceived Stress Level among the Indian Medical Graduate
Authors: Kumar Parveen , Patel Vishal Kanaiyalal , Tiwari Deepak Sachidanand , Vasavada Disha Alkeshbhai , Bhatt Renish Bhupendraderbhai , Chanpa Nirav Bhupendraderbhai 
Published: July 2021

Background:
Problematic gaming use is prevalent among the adolescents and young adults. The awareness of problematic gaming as a behavioral addiction is low in the community.

Aims:
This study was aimed to find the prevalence of problematic gaming, gaming pattern, and perceived stress level among Indian medical graduates.

Methods:
A total of 922 undergraduate medical students participated in this cross-sectional study. Demographic details, different gaming variables, “internet gaming disorder scale short form (IGDS9),” and “Perceived stress scale” were filled by participants using the Google form.

Results:
Out of 595 students, 8.71% reported problematic gaming use. Positive correlation was observed between Internet gaming disorder score and perceived stress score (r = 0.446, P < 0.001). Male participants, younger age group, first year medical students, and participants playing more hours per day were associated with higher score on IGDS (P < 0.001). Positive correlation was observed between the duration of game play (in years) with IGDS score (r = 0.359, P < 0.001). Action games playing participants had higher score on Gaming Disorder Scale followed by simulation games playing participants (P = 0.001).

Conclusion:
Problematic gaming use is prevalent behavioral addiction among the medical students. Students with problematic gaming reported a high level of stress. Education and interactive workshop of problematic gaming should be conducted as a part of foundation course in the medical education.