bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceptions, behaviours and attitudes towards smoking held by the male partners of Chinese pregnant women: A qualitative study
Authors: XIA Wei , Li Ho cheung William , Song Peige , Ho Ka Yan , Luo Yuanhui , Liang Tingna , Ho Laurie Long Kwan , Cheung Ankie Tan , Cai Wenzhi 
Published: April 2021

Abstract
Background: Direct associations of tobacco exposure during pregnancy with pregnancy complications and adverse birth outcomes have been proven. Previous studies suggest that expecting a child provides a teachable moment to promote behavioural changes, such as smoking cessation, among the male partners of pregnant women. Thorough understandings of Chinese expectant fathers smoking behaviour during the transition to fatherhood is an essential prerequisite to the development of appropriate interventions to facilitate smoking cessation. This study aimed to explore the perceptions, behaviours and attitudes related to smoking among male partners of pregnant women in China.Methods: A descriptive phenomenological approach was adopted. A purposive sample of expectant fathers aged 18 years or older who had a tobacco use history within the past year were recruited at obstetrics and gynaecology clinics and invited to participate in one-to-one 20-30-minute semi-structured interviews. The data analysis followed Colaizzi’s descriptive phenomenological method. Results: Twenty-five expectant fathers were interviewed. Four themes were generated: 1) the social interaction benefits of smoking and the misperceptions of the smoking hazards were the major reasons for continuing smoking; 2) associations between the perceptions of health and smoking, included negative impact of smoking on their own health develops slowly and can be ignored, and secondhand smoke will not affect the health of foetuses; 3) factors contributing to smoking cessation, including concerns about the health of the pregnant partner and baby, the role of father, partners’ pregnancy as a good excuse, and encouragement of family members and recognition of efforts to quit smoking;, and 4) perceived barriers to smoking cessation, including difficulties in overcoming withdrawal symptoms or cigarette cravings, negative attitude toward seeking assistance with smoking cessation, unawareness of and difficulty in accessing smoking cessation support, and Lack of coping strategies for releasing increased stress..Conclusion: This study provides a comprehensive understanding of the perceptions, behaviours and attitudes held by Chinese expectant fathers regarding smoking and identified the facilitators and barriers to cessation. The findings from this study could direct healthcare professionals to develop and evaluate appropriate smoking cessation interventions targeted for Chinese expectant fathers. Trial registration: Registered at clinicaltrial.org (NCT03401021) on 8 Jan 2018.
A Disorder Easy to be Misdiagnosed--benign Metastasizing Uterine Leiomyoma with Multiple Metastasis to Lungs and Pelvic Lymph Nodes Simultaneously and Literature Review
Authors: tong tong , Fan Qiong , Wang Yudong , Li Yuhong 
Published: April 2021

Abstract
Background: Benign metastasizing leiomyoma (BML) is a rare disease that is usually seen in females of reproductive or premenopausal age with a previous surgery history of uterine myomectomy or hysterectomy. The most common sites of metastases are pulmonary metastases, and other sites include heart, bones, liver, lymph nodes, skin, bladder, esophagus, skeletal muscles, and central nervous system. Here we report a case of 50-year-old women with history of hysterectomy whom was first suspect uterine sarcoma but finally confirmed BML with lung and lymph node metastases at the same time and discuss the treatment and prognosis of BML. Case presentation: A 50-year-old women who have a history of abdominal total hysterectomy presented with mild but persistent abdominal pain for over 3 months. She was suspected uterine sarcoma before surgery and laparoscopic extensive debulking surgery including bilateral oophorectomy, pelvic and para-aortic lymph node dissection to the level of the left renal vein, and right inguinal lymph nodes dissection trans-cutaneously were done. Pathology after surgery confirmed benign leiomyoma and she was diagnosed BML. No medicine was given after the surgery and now the follow up is of no significance. Conclusions: Benign metastasizing leiomyoma (BML) is a rare disorder in which histologically benign smooth muscle tumor metastasize to extra-uterine sites. Metastases are commonly seen in the lung, liver, lymph nodes, skin, bladder, esophagus, skeletal muscles, et al. BML is usually misdiagnosed as malignant tumor before surgery until pathology confirmed the benign nature. The treatment is controversial and undetermined. The prognosis is usually favorable because of its benign nature.
Effect of surgical stabilization of rib fractures in polytrauma - an analysis of the&nbsp;TraumaRegister DGU®
Authors: Becker Lars , Schulz-Drost Stefan , Spering Christopher , Franke Axel , Dudda Marcel , Lefering Rolf , Matthes Gerrit , Bieler Dan 
Published: April 2021

Abstract
Purpose: In severely injured patients with multiple rib fractures the beneficial effect of surgical stabilization is still unknown. The existing literature shows divergent results and especially the indication and the right timing of an operation are subject of a broad discussion. The aim of this study was to determine the influence of a surgical stabilization of rib fractures (SSRF) on the outcome in a multi-center database with special regard to the duration of ventilation, intensive care and overall hospital stay.Methods: Data from the TraumaRegister DGU® collected between 2008 and 2017 were used to evaluate patients over 16 years with severe rib fractures (AIS ≥3). In addition to the basic comparison a matched pair analysis of 395 pairs was carried out in order to find differences and to increase comparability.Results: In total 483 patients received an operative treatment and 29,447 were treated conservatively. SSRF was associated with a significantly lower mortality rate (7.6% vs. 3.3%, p = 0.008) but a longer ventilation time and longer stay as well as in the intensive care unit (ICU) as the overall hospital stay. Both matched pair groups showed a good or very good neurological outcome according to the Glasgow Outcome Scale (GOS) in 4 of 5 cases. Contrary to the existing recommendations most of the patients were not operated within 48 hours.Conclusions: In our data set obviously most of the patients were not treated according to the recent literature and showed a delay in the time for operative care of well over 48 hours. This may lead to an increased rate of complications and a longer stay at the ICU and the hospital in general. Despite of these findings patients with operative treatment show a significant lower mortality rate.
YAP regulates porcine skin-derived stem cells self-renewal partly by repressing Wnt/β-catenin signaling pathway
Authors: Yan Hong-Chen , Sun Yu , Zhang Ming-Yu , Zhang Shu-Er , Sun Jia-Dong , Dyce Paul W. , Klinger Francesca Gioia , De Felici Massimo , Shen Wei , Cheng Shun-Feng 
Published: April 2021

Abstract
Background
Skin-derived stem cells (SDSCs) are a class of adult stem cells (ASCs) that have the ability to self-renew and differentiate. The regulation mechanisms involved in the differentiation of ASCs is a hot topic. Porcine models have close similarities to humans and porcine SDSCs (pSDSCs) offer an ideal in vitro model to investigate human ASCs. To date, studies concerning the role of yes-associated protein (YAP) in ASCs are limited, and the mechanism of its influence on self-renewal and differentiation of ASCs remain unclear. In this paper, we explore the link between the transcriptional regulator YAP and the fate of pSDSCs.
Results
We found that YAP promotes the pluripotent state of pSDSCs by maintaining the high expression of the pluripotency genes Sox2, Oct4. The overexpression of YAP prevented the differentiation of pSDSCs and the depletion of YAP by small interfering RNA (siRNAs) suppressed the self-renewal of pSDSCs. In addition, we found that YAP regulates the fate of pSDSCs through a mechanism related to the Wnt/β-catenin signaling pathway. When an activator of the Wnt/β-catenin signaling pathway, CHIR99021, was added to pSDSCs overexpressing YAP the ability of pSDSCs to differentiate was partially restored. Conversely, when XAV939 an inhibitor of Wnt/β-catenin signaling pathway, was added to YAP knockdown pSDSCs a higher self-renewal ability resulted.
Conclusions
our results suggested that, YAP and the Wnt/β-catenin signaling pathway interact to regulate the fate of pSDSCs.
Colorimetric parameters correlated with the variation in the marker constituent contents during the stir-fry processing of Schizonepetae Spica
Authors: Liu Xindan , Zhang Ying , Wu Menghua , Ma Zhiguo , Cao Hui 
Published: April 2021

Abstract
Background: Color is an important method of authentication to evaluate the degree of Chinese medicinal material (CMM) processing. This traditional color description used for identification needs to be confirmed by modern scientific analysis. Schizonepetae Spica (SS), the dried spike of Schizonepeta tenuifolia Briq., is a traditional Chinese medicinal herb. Raw SS has the actions of dispelling the common cold and fever. Schizonepetae Spica Carbonisata (SSC; raw SS processed by stir-frying until the surface becomes blackish-brown and the interior turns dark yellow) has particularly strong efficacy in arresting bleeding from bloody stool and metrorrhagia. Methods: In this paper, a high-performance liquid chromatography-diode array detector method and colorimetry were employed to determine 6 nonvolatile marker constituents and the color parameters (L*, a* and b*) of SS during stir-fry processing, respectively. Results: According to Pearson correlation analysis, L*, a* and b* showed significant correlations with the levels of luteolin-7-O-β-D-glucoside, apigenin-7-O-β-D-glucoside, hesperidin and rosmarinic acid, while a* was significantly correlated with the amounts of luteolin and apigenin. The corresponding regression models were good fits for the color parameters as respective functions of the 6 marker constituents according to enter multiple linear regression and third-order polynomial curve fitting methods (adjusted R2 > 0.800). Conclusion: Surrogate prediction of marker compounds using color parameters provides a valuable and cost-saving tool for rapid or online monitoring of the processing degree of SS. Raw SS and SSC could be determined based on the color parameters and 6 marker constituent contents for a comprehensive quality evaluation for the first time. This paper provides scientific data to validate the relationships between color features and quality during the processing of SS.
A 3D Deep Learning Model to Predict the Diagnosis of Dementia with Lewy Bodies, Alzheimer’s Disease and Mild Cognitive Impairment Using Brain 18F-FDG PET
Authors: Etminani Kobra , Soliman Amira , Davidsson Anette , Chang Jose , Martínez-Sanchis Begoña , Byttner Stefan , Camacho Valle , Bauckneht Matteo , Stegeran Roxana , Ressner Marcus , Agudelo-Cifuentes Marc , Chincarini Andrea , Brendel Matthias , Rominger Axel , Bruffaerts Rose , Vandenberghe Rik , Kramberger Milica , Trost Maja , Nicastro Nicolas , Frisoni Giovanni , Lemstra Afina , Berckel Bart van , Pilotto Andrea , Padovani Alessandro , Morbelli Silvia , Aarsland Dag , Nobili Flavio , Garibotto Valentina , Ochoa-Figueroa Miguel 
Published: April 2021

Abstract
PurposeThe purpose of this study is to develop and validate a 3D deep learning model that predicts the final clinical diagnosis of Alzheimer’s disease (AD), Dementia with Lewy Bodies (DLB), Mild Cognitive Impairment due to Alzheimer’s disease (MCI-AD), and cognitively normal (CN) using fluorine 18 fluorodeoxyglucose PET (18F-FDG PET) and compare model’s performance to that of multiple expert nuclear medicine physicians’ readers.Materials and MethodsRetrospective 18F-FDG PET scans for AD, MCI-AD, and CN were collected from Alzheimer’s Disease Neuroimaging Initiative (556 patients from 2005 to 2020), and CN and DLB cases were from European DLB Consortium (201 patients from 2005 to 2018). The introduced 3D convolutional neural network was trained using 90% of the data and externally tested using 10% as well as comparison to human readers on the same independent test set. The model’s performance was analyzed with sensitivity, specificity, precision, F1 score, receiver operating characteristic (ROC). The regional metabolic changes driving classification were visualized using uniform manifold approximation and projection (UMAP) and network attention.Results The proposed model achieved area under the ROC curve of 96.2% (95% confidence interval: 90.6-100) on predicting the final diagnosis of DLB in the independent test set, 96.4% (92.7-100) in AD, 71.4% (51.6-91.2) in MCI-AD, and 94.7% (90-99.5) in CN, which in ROC space outperformed human readers performance. The network attention depicted the posterior cingulate cortex is important for each neurodegenerative disease, and the UMAP visualization of the extracted features by the proposed model demonstrates the reality of development of the given disorders.Conclusion Using only 18F-FDG PET of the brain, a 3D deep learning model could predict the final diagnosis of the most common neurodegenerative disorders which achieved a competitive performance compared to the human readers as well as their consensus.
Hybrid Deep Learning based approach for ECG Heartbeat Arrhythmia Classification
Authors: Madan Parul , Singh Vijay , Singh Devesh Pratap , Pant Bhasker 
Published: April 2021

Abstract
Background: Myocardial infarction, or heart attack, is caused by a blockage of a coronary artery, which prevents blood and oxygen from accessing the heart properly. Arrhythmias are a form of CVD that refers to irregular variations in the normal heart rhythm, such as the heart beating too quickly or too slowly. Arrhythmias include Atrial Fibrillation(AF),Premature Ventricular Contraction(PVC), Ventricular Fibrillation(VF), and Tachycardia are just a few examples of arrhythmias. It aggravates if not detected and treated on time i.e., on-time /proper diagnosis of arrhythmias may minimize the risk of death. It is very labor-intensive to externally evaluate ECG signals, due to their small amplitude. Furthermore, the analysis of ECG signals is arbitrary and can differ between experts. As a consequence, a computer-aided diagnostic device that is more objective and reliable is needed. Methods: In the recent era, Machine Learning based approaches to detect arrhythmias has been established proficiently. In this view, we proposed a hybrid Deep Learning-based model to detect three types of arrhythmias on MIT-BIH arrhythmia databases. In particular, this paper makes two-fold contributions. First, we translated 1D ECG signals into 2D Scalogram images. When one-dimensional ECG signals are turned into two-dimensional ECG images, noise filtering and feature extraction are no longer necessary. This is notable since certain ECG beats are ignored by noise filtering and feature extraction. Then, based on experimental evidence, we suggest combining two models, 2D-CNN-LSTM, to detect three forms of arrhythmias: Cardiac Arrhythmias (ARR), Congestive Heart Failure (CHF), and Normal Sinus Rhythm (NSR). Results: The experimental findings indicate that the model attained 99\% accuracy for "normal sinus rhythm," 100\% accuracy for "cardiac arrhythmias," and 99\% accuracy for "congestive heart failures," with an overall classification accuracy of 98.6\%. The sensitivity and specificity were 98.33\% and 98.35\%, respectively. The proposed model, in particular, will aid doctors in correctly detecting arrhythmia during routine ECG screening. Conclusion: As compared to the other State-of-the-art methods our proposed model outperformed and will greatly minimise the amount of intervention required by doctors.
Superfluid Density and Collective Modes of Fermion Superfluid in Dice Lattice
Authors: Wu Yu-Rong , Zhang Xiao-Fei , Liu Chao-Fei , Liu Wu-Ming , Zhang Yi-Cai 
Published: April 2021

Abstract
The superfluid properties of attractive Hubbard model in dice lattice are investigated. It is found that three superfluid order parameters increase as the interaction increases. When the filling factor falls into the flat band, due to the infinite large density of states, the resulting superfluid order parameters are proportional to interaction strength, which is in striking contrast with the exponentially small counterparts in usual superfluid (or superconductor). When the interaction is weak and the filling factor is near the bottom of lowest band (or the top of highest band), the superfluid density is determined by the effective mass of the lowest (or highest) single-particle band. When the interactions is strong and filling factor is small, the superfluid density is inversely proportional to interaction strength, which is related to effective mass of tightly bound pairs. In the strong interaction limit and finite filling, the asymptotic behaviors of superfluid density can be captured by a parabolic function of filling factor. Further more, when the filling is in flat band, the superfluid density shows a logarithmic singularity as the interaction approaches zero. In addition, there exist three undamped collective modes for strong interactions. The lowest excitation is gapless phonon, which is characterized by the total density oscillations. The two others are gapped Leggett modes, which correspond relative density fluctuations between sublattices. The collective modes are also reflected in the two-particle spectral functions by sharp peaks. Further more, it is found that the two-particle spectral functions satisfy an exact sum-rule, which is directly related to the filling factor (or density of particle). The sum-rule of the spectral functions may be useful to distinguish the hole-doped or particle-doped superfluid (superconductor) in experiments.
Exosomes derived from bone marrow mesenchymal stem cells promote angiogenesis via transfer of miR-21-5p after cerebral ischemia in mice
Authors: Hu Hui , Hu xiaowei , Li lin , Gu Jingjing , Fang Yan , Yang Yan , Xu Jiadong , Chu Lisheng 
Published: April 2021

Abstract
Background

Mesenchymal stem cells (MSCs) transplantation is a potential clinical therapy for cerebral ischemia. The therapeutic effects of MSCs primarily depends on the paracrine action by releasing exosomes (Exos). Exosomes derived from bone marrow mesenchymal stem cells (BMSC-Exos) could modulate target cell functions by transferring microRNAs (miRs) cargo. In this study, we aimed to investigate whether BMSC-Exos could promote angiogenesis via transfer of miR-21-5p after cerebral ischemia.
Methods

BMSC-Exos were isolated from conditioned medium of BMSCs by differential ultracentrifugation, and confirmed by transmission electron microscopy, nanoparticle tracking analysis, and western blot analysis. In mice with middle cerebral artery occlusion (MCAO), the neurological function was evaluated by Zea Longa’s method, and the infarct volume and microvessel density were detected by TTC staining and vWF immunofluorescence staining, respectively. The proangiogenic effects of BMSC-Exos were assessed via proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs) in vitro assays. The miR-21-5p expression was detected by qRT-PCR. The expression levels of VEGF, VEGFR2, Ang-1, and Tie-2 were determined by western blot.
Results

BMSC-Exos significantly improved neurological function and reduced infract volume after cerebral ischemia. Moreover, BMSC-Exos significantly upregulated the microvessel density and the expression levels of proangiogenic proteins VEGF, VEGFR2, Ang-1 and Tie-2 in the ischemic boundary region. MiR-21-5p expression was also dramatically increased after cerebral ischemia. In vitro assays revealed that BMSC-Exos enhanced HUVECs functions including proliferation, migration and tube formation, as well as increasing the expression of VEGF and VEGFR2. However, these proangiogenic effects of BMSC-Exos on HUVECs were reversed by miR-21-5p inhibitor.
Conclusion

Our study indicated that BMSC-Exos could promote angiogenesis and neurological function recovery via transfer of miR-21-5p. Therefore, the application of miR-21-5p-loaded BMSC-Exos might be an attractive treatment strategy of cerebral ischemia.
Sprawowanie władzy w instytutach życia konsekrowanego i stowarzyszeniach życia apostolskiego w świetle instrukcji „Posługa władzy i posłuszeństwo. Faciem tuam, Domine, requiram” z 2008 roku
Authors: Necel Wojciech 
Published: April 2021

Das Gelübde des Gehorsams der Personen des konsekrierten Lebens durch das Gelübde oder andere Verpflichtungen als Geschenk des Heiligen Geistes (CIC c. 601) fordert die christologische Basis und das Verstehen in personaler sowie gemeinschaftlicher Dimension in Verbindung mit dem evangelischen Autorität von Oberen in der Apostolatsperspektive im Dienst des Reichs Gottes. Die Instruktion der Kongregation für die Institute des konsekrierten Lebens und die Vereine des apostolischen Lebens „Der Dienst der Macht und des Gehorsams, Faciem tuam, Domine, requiram“ vom 11. Mai 2008 bringt eine gute Möglichkeit, um durch das vorgeschlagene Dokument eine Relecture von Kodexnormen des Kodex Iuris Cannonici vom 1983 bezüglich der Ausübung der Macht durch die Oberen in Ordensgemeinschaften und in Vereinen des apostolischen Lebens vorzunehmen. Es ist wichtig anzumerken (das lernt die apostolische Kongregation), dass auch andere Personen abhängig vom Lebensstil von der Instruktion profitieren können. Allen Personen, die berufen sind das Primat Gottes zu bezeugen durch das freiwillige Erleben des in Freude erlebten eigenen „Ja“ hat die Instruktion etwas zu sagen. In diesem Artikel bezieht sich der Autor auf (bezugnehmend auf die Richtlinien des Dokuments) die christologischen Quellen der Macht der Oberen in Ordensinstituten und in Vereinen des apostolischen Lebens und auch auf die Macht der Oberen als eine Ableitung des Gelübdes des Gehorsams. Weiterer wird die Natur der Macht der Oberer beschrieben und die dreifache Funktion dieser Macht um zu zeigen, dass die endgültige Macht der Oberen in dem Ablesen der Wille Gottes bezüglich der anvertrauten Gemeinschaft sowie jedes einzelnen Bruder und Schwester und als potestas regimins anzusehen ist, die sich in Sorge um die Realisierung des Zieles, der aus dem Charisma des Institutes oder des Vereins des apostolischen Lebens ausdrückt.