bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of hepatic zonation in mice by mass-spectrometric and antibody-based proteomics approaches
Authors: Kling Simon , Lang Benedikt , Hammer Helen S. , Naboulsi Wael , Sprenger Heike , Frenzel Falko , Pötz Oliver , Schwarz Michael , Braeuning Albert , Templin Markus F. 
Published: October 2021

Abstract
Periportal and perivenous hepatocytes show zonal heterogeneity in metabolism and signaling. Here, hepatic zonation in mouse liver was analyzed by non-targeted mass spectrometry (MS) and by the antibody-based DigiWest technique, yielding a comprehensive overview of protein expression in periportal and perivenous hepatocytes. Targeted immunoaffinity-based proteomics were used to substantiate findings related to drug metabolism. 165 (MS) and 82 (DigiWest) zonated proteins were identified based on the selected criteria for statistical significance, including 7 (MS) and 43 (DigiWest) proteins not identified as zonated before. New zonated proteins especially comprised kinases and phosphatases related to growth factor-dependent signaling, with mainly periportal localization. Moreover, the mainly perivenous zonation of a large panel of cytochrome P450 enzymes was characterized. DigiWest data were shown to complement the MS results, substantially improving possibilities to bioinformatically identify zonated biological processes. Data mining revealed key regulators and pathways preferentially active in either periportal or perivenous hepatocytes, with β-catenin signaling and nuclear xeno-sensing receptors as the most prominent perivenous regulators, and several kinase- and G-protein-dependent signaling cascades active mainly in periportal hepatocytes. In summary, the present data substantially broaden our knowledge of hepatic zonation in mouse liver at the protein level.
Marshall-Olkin Lindley-Log-logistic distribution: Model, properties and applications
Authors: Moakofi Thatayaone , Oluyede Broderick , Makubate Boikanyo 
Published: October 2021

Abstract
The authors introduce a new generalized distribution called the Marshall-Olkin Lindley-Log-logistic (MOLLLoG) distribution and discuss its distributional properties. The properties include hazard function, quantile function, moments, conditional moments, mean and median deviations, Bonferroni and Lorenz curves, distribution of the order statistics and Rényi entropy. A Monte Carlo simulation study was used to examine the bias, relative bias and mean square error of the maximum likelihood estimators. The betterness of the new distribution compared to other distributions is illustrated by means of two real life datasets.
Novel drug design and bioinformatics: an introduction
Authors: Khan Mohammad Kalim Ahmad , Akhtar Salman 
Published: October 2021

Abstract
In the current era of high-throughput technology, where enormous amounts of biological data are generated day by day via various sequencing projects, thereby the staggering volume of biological targets deciphered. The discovery of new chemical entities and bioisosteres of relatively low molecular weight has been gaining high momentum in the pharmacopoeia, and traditional combinatorial design wherein chemical structure is used as an initial template for enhancing efficacy pharmacokinetic selectivity properties. Once the compound is identified, it undergoes ADMET filtration to ensure whether it has toxic and mutagenic properties or not. If the compound has no toxicity and mutagenicity is either considered a potential lead molecule. Understanding the mechanism of lead molecules with various biological targets is imperative to advance related functions for drug discovery and development. Notwithstanding, a tedious and costly process, taking around 10–15 years and costing around $4 billion, cascaded approached of Bioinformatics and Computational biology viz., structure-based drug design (SBDD) and cognate ligand-based drug design (LBDD) respectively rely on the availability of 3D structure of target biomacromolecules and vice versa has made this process easy and approachable. SBDD encompasses homology modelling, ligand docking, fragment-based drug design and molecular dynamics, while LBDD deals with pharmacophore mapping, QSAR, and similarity search. All the computational methods discussed herein, whether for target identification or novel ligand discovery, continuously evolve and facilitate cost-effective and reliable outcomes in an era of overwhelming data.
The suite of Taylor–Galerkin class schemes for ice transport on sphere implemented by the INMOST package
Authors: Petrov Sergey S. , Iakovlev Nikolay G. 
Published: October 2021

AbstractRealizations of the numerical solution of the scalar transport equation on the sphere, written in divergent form, are presented. Various temporal discretizations are considered: the one-step Taylor–Galerkin method (TG2), the two-step Taylor–Galerkin method of the second (TTG2), third (TTG3), and fourth (TTG4) orders. The standard Finite-Element Galerkin method with linear basis functions on a triangle is applied as spatial discretization. The flux correction technique (FCT) is implemented. Test runs are carried out with different initial profiles: a function fromC∞(Gaussian profile) and a discontinuous function (slotted cylinder). The profiles are advected by reversible, nondivergent velocity fields, therefore the initial distribution coincides with the final one. The case of a divergent velocity field is also considered to test the conservation and positivity properties of the schemes. It is demonstrated that TG2, TTG3, and TTG4 schemes with FCT applied give the best result for small Courant numbers, and TTG2, TTG4 are preferable in case of large Courant number. However, TTG2+FCT scheme has the worst stability. The use of FCT increases the integral errors, but ensures that the solution is positive with high accuracy. The implemented schemes are included in the dynamic core of a new sea ice model developed using the INMOST package. The acceleration of the parallel program and solution convergence with spatial resolution are demonstrated.
Disrupting Short-Term Memory Maintenance in Premotor Cortex Affects Serial Dependence in Visuomotor Integration
Authors: de Azevedo Neto Raymundo Machado , Bartels Andreas 
Published: October 2021

Human behavior is biased by past experience. For example, when intercepting a moving target, the speed of previous targets will bias responses in future trials. Neural mechanisms underlying this so-called serial dependence are still under debate. Here, we tested the hypothesis that the previous trial leaves a neural trace in brain regions associated with encoding task-relevant information in visual and/or motor regions. We reasoned that injecting noise by means of transcranial magnetic stimulation (TMS) over premotor and visual areas would degrade such memory traces and hence reduce serial dependence. To test this hypothesis, we applied bursts of TMS pulses to right visual motion processing region hV5/MT+ and to left dorsal premotor cortex (PMd) during intertrial intervals of a coincident timing task performed by twenty healthy human participants (15 female). Without TMS, participants presented a bias toward the speed of the previous trial when intercepting moving targets. TMS over PMd decreased serial dependence in comparison to the control Vertex stimulation, whereas TMS applied over hV5/MT+ did not. In addition, TMS seems to have specifically affected the memory trace that leads to serial dependence, as we found no evidence that participants' behavior worsened after applying TMS. These results provide causal evidence that an implicit short-term memory mechanism in premotor cortex keeps information from one trial to the next, and that this information is blended with current trial information so that it biases behavior in a visuomotor integration task with moving objects.SIGNIFICANCE STATEMENTHuman perception and action are biased by the recent past. The origin of such serial bias is still not fully understood, but a few components seem to be fundamental for its emergence: the brain needs to keep previous trial information in short-term memory and blend it with incoming information. Here, we present evidence that a premotor area has a potential role in storing previous trial information in short-term memory in a visuomotor task and that this information is responsible for biasing ongoing behavior. These results corroborate the perspective that areas associated with processing information of a stimulus or task also participate in maintaining that information in short-term memory even when this information is no longer relevant for current behavior.
Pituitary surgery as alternative to dopamine agonists treatment for microprolactinomas: a cohort study
Authors: Baussart Bertrand , Villa Chiara , Jouinot Anne , Raffin-Sanson Marie-Laure , Foubert Luc , Cazabat Laure , Bernier Michèle , Bonnet Fideline , Dohan Anthony , Bertherat Jerome , Assié Guillaume , Gaillard Stephan 
Published: October 2021

Objective
Microprolactinomas are currently treated with dopamine agonists. Outcome information on microprolactinoma patients treated by surgery is limited. This study reports the first large series of consecutive non-invasive microprolactinoma patients treated by pituitary surgery and evaluates the efficiency and safety of this treatment.

Design
Follow-up of a cohort of consecutive patients treated by surgery.

Methods
Between January 2008 and October 2020, 114 adult patients with pure microprolactinomas were operated on in a single tertiary expert neurosurgical department, using an endoscopic endonasal transsphenoidal approach. Eligible patients presented with a microprolactinoma with no obvious cavernous invasion on MRI. Prolactin was assayed before and after surgery. Disease-free survival was modeled using Kaplan–Meier representation. A cox regression model was used to predict remission.

Results
Median follow-up was 18.2 months (range: 2.8–155). In this cohort, 14/114 (12%) patients were not cured by surgery, including ten early surgical failures and four late relapses occurring 37.4 months (33–41.8) after surgery. From Kaplan–Meier estimates, 1-year and 5-year disease free survival was 90.9% (95% CI: 85.6–96.4%) and 81% (95% CI: 71.2–92.1%) respectively. The preoperative prolactinemia was the only significant preoperative predictive factor for remission (P < 0.05). No severe complication was reported, with no anterior pituitary deficiency after surgery, one diabetes insipidus, and one postoperative cerebrospinal fluid leakage properly treated by muscle plasty.

Conclusions
In well-selected microprolactinoma patients, pituitary surgery performed by an expert neurosurgical team is a valid first-line alternative treatment to dopamine agonists.
Digital Profile: Main Risks for Constitutional Human Rights in the face of Legal Uncertainty
Authors: Mochalov A. N. 
Published: October 2021

The paper considers the main threats to human rights in connection with the introduction of digital profiles in the Russian Federation. Rights such as the right to privacy and the right to dignity are most at risk. In addition, the risk of discrimination increases. Analyzing the current legal regulation of the digital profile, the author concludes that it does not meet the criterion of legal certainty and creates increased risks of intrusion of the state and private structures into the sphere of a person’s private life. Despite the fact that currently digital profiles of citizens are only a set of official information contained in some state information systems and public registers, according to the author, in the future, this infrastructure can be used for profiling people, in-depth analysis, monitoring and forecasting their behavior, as is already done today by some other states and nongovernmental organizations.The legal regulation of the digital profile should be based on special guarantees of human rights in connection with the collection and processing of personal information about citizens available to the state. Among such guarantees, the author includes, in particular, the establishment in the law of a list of information that cannot be part of a digital profile of a citizen or be otherwise related to it, a list of unacceptable purposes for using digital profiles, as well as the establishment of the obligation of operators to inform subjects in an accessible form about the facts and legal consequences of profiling, about the principles and logical schemes underlying profiling.
Combined method of preparing the cervix uteri for labor in pregnant women with a lack of birth preparedness and a tendency to post-term pregnancy
Authors: Burkitova Ainura M. , Bolotskikh Vyacheslav M. 
Published: October 2021

Objective. Development of an effective method for preparing the cervix in pregnant women with a tendency to overmaturity against the background of a lack of biological readiness for childbirth, as well as reducing the time for preparing the soft birth canal for childbirth in order to conduct subsequent labor excitation.
Material and methods. The patients were divided into 3 groups depending on the method of preparing the cervix for childbirth: in the 1st group (n = 50) only laminaria was used; in group 2 (n = 50), a Foley catheter was used in combination with mifepristone; in group 3 (n = 50), only mifepristone was used. Inclusion criteria: gestational period 41 weeks 41 weeks and 4 days inclusive, immature cervix (baseline score on the Bishop scale 0-2 points), singleton pregnancy, cephalic presentation, whole fetal bladder, vaginal cleanliness I-II, satisfactory fetal condition (normal type of curve according to CTG and the absence of fetal hemodynamic disorders according to Doppler data). Statistical processing of the obtained data was carried out using the STATISTICA 10.0 program.
Research results. The patients of the three groups were comparable in age, gestational age, and did not differ in the parity of childbirth and body mass index. With the combined preparation of the cervix for childbirth with mifepristone and a Foley catheter, the dynamics of the assessment of the cervix on the Bishop scale is higher and achieved faster than when preparing for childbirth only with laminaria or only antigestagens. When combining mifepristone with a catheter Foley, it is possible to reduce the time interval from the onset of pre-induction to the development of labor in comparison with pre-induction of labor only with mifepristone or only with the help of laminaria, as well as reduce the frequency of caesarean section due to the lack of effect from induction of labor compared with pre-induction of labor only with mifepristone or only with the help of laminaria. The undoubted advantage of this combined method of preparing the cervix for childbirth is its effectiveness, low risk of uterine hyperstimulation, fetal distress syndrome, as well as the absence of a high risk of developing infectious complications.
Conclusion. The combined method of preparing the body for childbirth with a tendency to post-term pregnancy is effective, safe and allows you to reduce the preparation time of the soft birth canal for childbirth against the background of a lack of biological readiness for childbirth with a tendency to post-term pregnancy.
Effective Factors in the Establishment and Implementation of Patient Electronic Referral System in the Healthcare System: A Qualitative Study
Authors: Tajari Fatemeh , Mahmoudi Ghahraman , Dabbaghi Fatemeh , Yazdani-Charati Jamshid 
Published: October 2021

Background and Purpose: The electronic referral system was established in Iran with the aim of increasing access to care, improving interaction, and efficient use of resources. The purpose of this study was to determine the effective factors in the establishment and implementation of electronic referral system in Iran.
Methods: The present study was qualitative with a content analysis approach. In order to collect information, in-depth and semi-structured interviews were used. After interviewing 42 people, the information was saturated. The interviews were transcribed and analyzed, and the main topics were quoted, cited, and coded. The content analysis method was used and all authors participated in the analysis process to avoid bias and agreement.
Results: Four main themes and eleven sub-themes were mentioned as effective themes in the implementation of the electronic referral system by the interviewees including resource management (human resource management, financing and equipment, and infrastructure), stewardship (policy-making, inter-sectorial leadership, and intra-sectorial governance), advocacy stakeholders (senior officials and policy-makers related to the program, service providers, community), and social commitment (commitment and accountability of service providers).
Conclusions: Successful implementation of electronic referral systems requires the development of an operational plan that correctly identifies the factors affecting the establishment and implementation, as well as the cooperation of all responsible organizations which can help improve the establishment and sustainability of the program. It is suggested that managers and officials active in the field of health services use the results of this study in the establishment and implementation of electronic referral system.
Oral Health Literacy and Oral Health Behavior among Adolescents in Babol 2019
Authors: Chaleshgar-Kordasiabi Mosharafeh , Chapary Salehe , Eshkevarkiayi Zahra , Rafinezhad-Naghibi Mina , Abbasi- Shavazi Masoumeh , Ramezan Atena 
Published: October 2021

Background: The process of obtaining oral health information, evaluating its concepts and using appropriate prevention and treatment processes in the field of Oral health literacy (OHL) is within the scope of health literacy and is the link between culture and society, health system, education system, and oral health consequences. The purpose of the current study was to investigate OHL in first-grade high school students in Babol.
Materials and Methods: The present study was a cross-sectional study on 383 high school students in Babol 2019 using the multi-stage cluster sampling method in the first stage of school selection and in the second stage of class selection. The data were collected using demographic, oral health behaviors assessment, and Oral Health Literacy Questionnaire. OHL questionnaire has 17 questions in four sections of reading comprehension, numeracy, listening, and decision making. Regression analysis, ANOVA, T-test, and chi-square test were used for data analysis (SPSS 23).
Findings: The mean score of students' OHL was 8.33 ± 2.004, and 11.7%, 26.1%, and 61.9% of the students were with adequate, borderline, and inadequate levels of OHL, respectively. According to the analysis, OHL had a significant relationship with income, father’s education, tooth brushing, and use of beverage foods.
Conclusion: The results showed that OHL was insufficient among students, and more efforts and interventions were required to improve oral health and increase oral health literacy among student.
Evaluation of Salinity Tolerant Wheat (Triticum aestivum L.) Genotypes through Multivariate Analysis of Agronomic Traits
Authors: Ashik Tahmidul , Islam Md. Moshiul , Rana Md. Sohel , Jahan Khurshida , Urmi Tahmina Akter , Jahan Nilufar Akhtar , Rahman Md. Mamunur 
Published: October 2021

Background: Wheat (Triticum aestivum L.) is the second major global cereals mostly grown in winter season which led wheat plants to suffer with salinity stress. Twenty to thirty percent of the arable land of the world is present in the saline area. Therefore, it is necessary to develop salinity tolerant wheat varieties to meet the future food demand. Methods: A field experiment was carried out during November 2018 to March 2019 to observe the effect of salinity on yield and other desired plant characters and finally screening of wheat genotypes for salinity tolerance. The experiment was laid out in a complete randomized design containing three treatments with three replications. The treatments were three levels of salinity such as control, 8 dS m-1 and 15 dS m-1. Multivariate and principal components analysis was executed to evaluate yield and other plant characters. Result: The results of the experiment revealed that different plant characters showed wide range of variation under different salinity levels. Biplot analysis considering PC1 and PC2 revealed that grain yield was positively correlated with grain spike-1, spike length, thousand seed weight and total tiller plant-1. Correlation study also revealed that total tiller plant-1, spikelet spike-1, grain spike-1 and thousand seed weight showed significant and positive relation with grain yield plant-1. On the basis of yield reduction percent and yield the genotypes G12 (2.51 g), G16 (2.49 g) and G4 (2.19 g) were found suitable for 15 dS m-1 salinity.
Fisuras labiopalatinas en el antiguo Perú
Authors: Paico-Vílchez Emiliano , Paico-Zumaeta Emiliano 
Published: October 2021

En este artículo, los autores muestran la presencia de las fisuras labiopalatinas entre los aborígenes peruanos, tal como fue representada en la cerámica de los Mochicas y Chimúes; así mismo, las referencias de los antiguos cronistas que los aborígenes tenían esta malformación congénita. La fisura labiopalatina es una malformación que fue frecuente entre los aborígenes peruanos. Era considerada un signo de poseer poderes sobrenaturales; y, a los portadores de esta malformación se les consideraba intermediarios entre lo divino y lo terrenal, por lo que podían desempeñarse como curanderos o sacerdotes.
Crustal Density and Susceptibility Structure beneath Achankovil Shear Zone, India
Authors: Prasad M. , Dubey C. P. , Joshi K. B. , Tiwari V. M. 
Published: October 2021

Abstract
The Southern Granulite Terrain (SGT) is a large tract of exposed Archean continental crust, divided into the Madurai Block (MB), Trivandrum Block (TB), and Nagercoil Block (NB). These crustal domains are linked with the NW-SE trending Achankovil Shear Zone (AKSZ). We combine gravity and magnetic data with previously published ground observations and geochronological data to re-evaluate the crustal architecture, evolution of the AKSZ, and possible extension of AKSZ into Madagascar. Analyses indicate that the long wavelength trends of the magnetic anomalies originate at ~20 km depth of different SGT blocks. These observations are corroborated with the gravity as well as computed gravity gradient anomalies. The presence of khondalite outcrops in Trivandrum Block implies that high magnetization crust is the main source of positive magnetic anomalies. Such magnetic anomalies advocate that SGT preserves the remanent of Archean crustal blocks in South India, a part due to variation in thermal and geochemical processes. The AKSZ, TB, and MB exhibit contrasting magnetic crustal signatures. The joint modeling results reveal a three-layered crustal configuration with varying Moho ranging from 41 to 34 km in NE to SW, respectively. It is also noted that AKSZ is a narrow and deep structure near to the Western Ghats Escarpment while it is wide and shallow in the far-east, which implies that the evolution of the Western Ghats is a late geological event.