bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based one-exercise program: A randomized dose-response trial of knee-extensor resistance exercise in patients eligible for knee replacement (the QUADX-1 trial)
Authors: Husted Rasmus Skov , Troelsen Anders , Husted Henrik , Grønfeldt Birk Mygind , Thorborg Kristian , Kallemose Thomas , Rathleff Michael Skovdal , Bandholm Thomas 
Published: April 2021

AbstractObjectiveTo investigate firstly the efficacy of three different dosages of one home-based, knee-extensor resistance exercise on knee-extensor strength in patients eligible for knee replacement, and secondly, the influence of exercise on symptoms, physical function and decision on surgery.MethodOne-hundred and forty patients eligible for knee replacement were randomized to three groups: 2, 4 or 6 home-based knee-extensor resistance exercise-sessions per week (group 2, 4 and 6 respectively) for 12 weeks. Primary outcome: isometric knee-extensor strength. Secondary outcomes: Oxford Knee Score, Knee injury and Osteoarthritis Outcome Score, average knee pain last week (0-10 numeric rating scale), 6-minute walk test, stair climbing test, exercise adherence and “need for surgery”.ResultsPrimary analysis: Intention-to-treat analysis of 140 patients did not find statistically significant differences between the groups from baseline to after 12 weeks of exercise in isometric knee-extensor strength: Group 2 vs. 4 (0.003 Nm/kg (0.2%) [95% CI -0.15 to 0.15], P=0.965) and group 4 vs. 6 (−0.04 Nm/kg (−2.7%) [95% CI -0.15 to 0.12], P=0.628). Secondary analysis: Intention-to-treat analyses showed statistically significant differences between the two and six sessions/week groups in favor of the two sessions/week group for Oxford Knee Score: 4.8 OKS points (15.2%) [1.3 to 8.3], P=0.008) and avg. knee pain last week (NRS 0-10): - 1.3 NRS points (−19.5%) [-2.3 to -0.2], P=0.018. After the 12-week exercise intervention, data were available for 117 patients (N=39/group): 38 (32.5%) patients wanted surgery and 79 (67.5%) postponed surgery. This was independent of exercise dosage.ConclusionIn patients eligible for knee-replacement we found no between-group differences in isometric knee extensor strength after 2, 4 and 6 knee-extensor resistance exercise sessions per week. We saw no indication of an exercise dose-response relationship for isometric knee-extensor strength and only clinically irrelevant within group changes. For some secondary outcome (e.g. KOOS subscales) we found clinically relevant within group changes, which could help explain why only one in three patients decided to have surgery after the simple home-based exercise intervention.Trial registrationClinicalTrials.gov identifier: NCT02931058. Preprint: https://doi.org/10.1101/2021.04.07.21254965.
Evaluation of the Efficacy and Safety of a Clinical Grade Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Patch: A Pre-Clinical Study
Authors: Miyagawa Shigeru , Kawamura Takuji , Ito Emiko , Takeda Maki , Iseoka Hiroko , Yokoyama Junya , Harada Akima , Mochizuki-Oda Noriko , Imanishi-Ochi Yukiko , Li Junjun , Sasai Masao , Kitaoka Fumiyo , Nomura Masaki , Amano Naoki , Takahashi Tomoko , Dohi Hiromi , Morii Eiichi , Sawa Yoshiki 
Published: April 2021

AbstractAimsCardiomyocyte-derived induced pluripotent stem cells (iPSCs) may represent a promising therapeutic strategy for severely damaged myocardium. This study aimed to assess the efficacy and safety of clinical grade human iPSC-derived cardiomyocyte (hiPSC-CM) patches and conduct a pre-clinical proof-of-concept analysis.Methods and resultsA clinical grade hiPSC line was established from peripheral blood mononuclear cells collected from a healthy volunteer homozygous for human leukocyte antigens and differentiated into cardiomyocytes using cytokines and chemical compounds. hiPSC-CMs were cultured on temperature-responsive culture dishes to fabricate the hiPSC-CM patch. The hiPSC-CMs expressed cardiomyocyte-specific genes and proteins while electrophysiological analyses revealed that hiPSC-CMs were similar to the human myocardium.In vitrosafety studies using cell growth, soft agar colony formation, and undifferentiated cell assays indicated that tumourigenic cells were not present. Moreover, no genomic mutations were discovered using whole genome and exome sequencing analysis. Tumour formation was not detected in anin vivotumourigenicity assay using NOG mice. General toxicity tests also showed no adverse events due to hiPSC-CM patch transplantation. An efficacy study using a porcine model of myocardial infarction demonstrated significantly improved cardiac function with angiogenesis and a reduction in interstitial fibrosis, which was enhanced by cytokine secretion from hiPSC-CM patches after transplantation. No lethal arrhythmias were observed.ConclusionhiPSC-CM patches show promise for future translational research and clinical trials for ischaemic heart failure.One-sentence summaryThis pre-clinical study provides a proof-of-concept of the safety and efficacy of hiPSC-CM patches for the treatment of heart failure.Translational PerspectiveRegenerative therapy using cells and tissues is attractive as a novel approach for treating severe heart failure. We focused on human iPS cell-derived cardiomyocytes (hiPSC-CMs) as a cell source. Using basic research, the characteristics of hiPSC, hiPSC-CMs, and hiPSC-CM patches were determinedin vitroandin vivo. We also conducted a pre-clinical study using a porcine model of myocardial infarction that confirmed the safety and efficacy of the hiPSC-CM patch, highlighting its potential for clinical application.
AAV-mediated gene therapy produces fertile offspring in theLhcgr-deficient mouse model of Leydig cell failure
Authors: Xia Kai , Wang Fulin , Lai Xingqiang , Luo Peng , Chen Hong , Ma Yuanchen , Huang Weijun , Ou Wangsheng , Li Yuyan , Feng Xin , Lei Zhenmin , Xiang’an Tu , Ke Qiong , Mao Frank F.X. , Deng Chunhua , Xiang Andy P. 
Published: April 2021

AbstractLeydig cell failure (LCF) caused by gene mutation results in testosterone deficiency and infertility. Serum testosterone levels can be recovered via testosterone replacement; however, established therapies have shown limited success in restoring fertility. Here, we used a luteinizing hormone/choriogonadotrophin receptor (Lhcgr)-deficient mouse model of genetic LCF to investigate the feasibility of gene therapy for restoring testosterone production and fertility. We screened several adeno-associated virus (AAV) serotypes and identified AAV8 as an efficient vector to drive exogenousLhcgrexpression in progenitor Leydig cells through interstitial injection. We observed considerable testosterone recovery and Leydig cell maturation after AAV8-Lhcgr treatment in pubertalLhcgr-/-mice. This gene therapy substantially recovered sexual development, partially restored spermatogenesis and effectively produced fertile offspring. Furthermore, these favorable effects could be reproduced in adultLhcgr-/-mice. Our proof-of-concept experiments in this mouse model demonstrate that AAV-mediated gene therapy may represent a promising therapeutic approach for patients with genetic LCF.
Blockchain connectivity inhibitors: weaknesses affecting supply chain interaction and resilience
Authors: Vivaldini Mauro , de Sousa Paulo Renato 
Published: April 2021

PurposeThe paper aims to further understanding of connectivity from the perspective of blockchain technology (BT) in the supply chain (SC). It presents the weaknesses (inhibitors) of connectivity during technology implementation, focusing on supply chain interaction and resilience.Design/methodology/approachRestricting the focus to digital connectivity, interaction and supply chain resilience, this paper uses a systematic literature review (SLR) to examine how the literature has addressed, related or flagged connectivity weaknesses affecting supply chain interaction and resilience.FindingsThis study highlights the influence of connectivity for blockchain-technology projects. Technical and organisational influencers that affect the adoption of technology in the SC are presented. These influencers support the factors proposed in this study regarding the weaknesses that negatively affect the interaction between the agents involved and the SC's resilience. The research suggests that the weaknesses are related to technical needs and the relationships between companies arising from functionalities.Research limitations/implicationsThis paper is restricted to a review of the theory and the researched material. Although the author was careful to choose the best search terms related to the research objective, some potentially relevant articles may have been excluded.Practical implicationsThe study summarises research on blockchain connectivity influencers in the SC, helping managers to anticipate and mitigate some of doubts and concerns in projects of this nature.Originality/valueThis is one of the first articles in the area of operations and SCs that addresses the topic of connectivity, focusing on its restrictive factors (connectivity inhibitors), in the context of blockchain implementation in the SC.
Online sustainability information disclosure of mold companies
Authors: Correia Elisabete , Garrido Susana , Carvalho Helena 
Published: April 2021

PurposeThe study aims to improve the understanding of the online sustainability disclosure phenomena considering the quantity and nature of the content of the information related to sustainability disclosed in the corporate website of companies, providing evidence about the website sustainability disclosure of different size companies and characterizing the website sustainability disclosure of the Portuguese mold companies.Design/methodology/approachA content analysis methodology was used to the corporate websites of 83 companies in the sample. A direct approach was followed where the researcher is asked to read and classify the text in a previously defined category, but where the possibility of identifying new categories from the collected data is not excluded.FindingsThe information on sustainability disclosed by the mold companies is limited, whether in quantity or concerning the type of information. The information disclosed about environmental and social aspects is scarcer, being the focus more on aspects related to the economic dimension of sustainability, particularly in the areas related to products and services and customers.Research limitations/implicationsThe research design can be broadened to include other sustainability dissemination tools and other research methodologies, such as case studies, to provide a deeper understanding of the concerns and initiatives/practices of sustainability of mold companies.Practical implicationsThis study contributes to the knowledge of sustainability dissemination practices in SMEs, an area of research that needs to be more explored and, in an industrial sector (molds) that have not received much attention in this area.Originality/valueBased on the premise of the importance of corporate sustainability communication, the study focuses on the Internet as an information dissemination tool. It provides indications on the theme and information type that can be used to report the company's sustainability.
Human resource practitioners as sexual harassment commissioners: Sisyphus amid gender inequalities
Authors: Kuna Shani , Nadiv Ronit 
Published: April 2021

PurposeThere has been ample research on the antecedents and consequences of workplace sexual harassment (WSH), a volatile issue in contemporary labor markets. There is, however, a lingering gap in the scholarly literature regarding the organizational practices involved in contending with WSH incidents following their occurrence. By exploring the practices and challenges of sexual harassment commissioners, a mandatory role performed by Israeli human resource practitioners, this study aims to unpack the embedded power dynamics, which construct how WSH is both deciphered and handled within organizations.Design/methodology/approachIn-depth semi-structured interviews were conducted with 45 sexual harassment commissioners (SHCs) in various business organizations in Israel to explore practitioners' conceptions of the challenges underlying their role. A grounded theory approach was utilized.FindingsThe findings demonstrate that, while SHCs seemingly are empowered by their exclusive authority to inquire into an intricate organizational matter, counter practices have emerged to undermine their authority and influence. This negatively affects their ability to reduce the prevalence of WSH. SHCs' attempts to approach WSH utilizing a power discourse are eroded by systematic barriers that channel them toward adoption of the default legal discourse. The latter frames WSH in terms of individual misconduct rather than as a phenomenon stemming from and expressive of organizational and societal gender inequalities.Research limitations/implicationsThis study does not represent the voices of WSH complainants or of top executives. The data focused on SHCs' descriptions of their role challenges.Practical implicationsImplications are suggested regarding the academic education and training of SHCs.Originality/valueThis study sheds light on covert and unspoken barriers to gender equality in the labor market.
Shelter management during pandemics: lessons from cascading risks of cyclones and COVID-19
Authors: Mohanty Sujit , Dabral Ambika , Chatterjee Ranit , Shaw Rajib 
Published: April 2021

Purpose
The concept of multi-purpose cyclone shelters has been found effective in saving various lives during past cyclones. The recent cyclone Amphan, which hit the Indian states of Odisha and West Bengal in the middle of pandemic COVID-19 has posed severe issues related to cyclone shelter management in the rural areas. The purpose of this paper is to investigate the case of Odisha in a pandemic and draw some key lessons of cyclone shelter management, which can be useful for future cascading risks in other parts of the country and the region.

Design/methodology/approach
Cyclone shelters are critical infrastructures in the management of cyclones, associated hazards and saving crucial lives. The effective management of shelters during emergencies is dependent on the existing institutional mechanism, local stakeholders and their understanding of the key functions of the emergency shelters. This paper reviews the key challenges through literature, reports and direct interviews of field professionals and practitioners.

Findings
In normal times, cyclone shelters are used as schools and their management lies with the local communities and/or elected bodies. Some of the key emerging issues include: the convincing population at risk for evacuation with proper care, existing emergency shelters being repurposed as COVID-19 facilities, need for hygiene and safety material, special arrangement and segregation of population at higher risk of COVID-19 and large destruction of social infrastructures.

Originality/value
During cascading disasters, adaptive governance becomes important. With the study of cyclones during the pandemic period, the paper draws key decision-making and governance points of cyclone shelter management. This case analysis can be useful to other similar situations during the prolonged pandemic time.
Impact of psychological factors, university environment and sustainable behaviour on teachers' intention to incorporate inclusive education in higher education
Authors: Bodhi Rahul , Singh Tripti , Joshi Yatish , Sangroya Deepak 
Published: April 2021

PurposeThe current study examines the impact of various psychological factors, university environment and sustainable behaviour on teachers' intention to incorporate inclusive education in higher education.Design/methodology/approachA cross-sectional survey was conducted to collect data from 204 academicians and scholars from India. Structural equation modelling (SEM) was employed to examine data.FindingsResults revealed that teachers' attitudes, university environment and spirituality had a positive and significant association with intention to incorporate inclusive education. Path analysis showed that teachers' attitude was the most prominent predictor of intention to incorporate inclusive education, followed by spirituality and university environment.Practical implicationsThe study determines the key predictors of teachers' intention to incorporate inclusive education. The identified factors can help the government and public policymakers foster inclusive education. The study determines that teachers have the capability to drive inclusive education through intrinsic spiritual views and feelings of satisfaction and happiness. Marketers must capitalize on the spiritual aspect of individuals and accordingly develop long-term inclusive strategies.Originality/valueThe current study addresses prevailing gaps in existing literature on teachers' attitude and intention to adopt inclusive education. The study examines the impact of key predictors of teachers' intention to adopt inclusive education and focuses on emerging factors such as university environment, spirituality, teachers' self-efficacy, concern and sustainable behaviour.
The effect of supply chain quality management on supply chain performance: the indirect roles of supply chain agility and innovation
Authors: Abdallah Ayman Bahjat , Alfar Nour A. , Alhyari Salah 
Published: April 2021

PurposeThe current study seeks to investigate how supply chain quality management (SCQM) and supply chain agility (SCA) and innovation (SCI) have an impact on supply chain performance (SCP) and how SCQM affects SCP through the mediating role of SCA and SCI capabilities.Design/methodology/approachIn line with the research objective, a quantitative model was applied, and a multi-item survey questionnaire was developed to collect primary data. A random sample of 284 manufacturing firms belonging to different industries was used. The measurement model was assessed for validity and reliability, and satisfactory levels of these tests were demonstrated. Research hypotheses were examined using structural equation modeling (SEM).FindingsThe results of the current study have significant implications in regard to the further improvement of SCP through SCQM. The study also found that SCQM plays a key role across the entire SC network in facilitating and developing SCA and SCI capabilities. The remarkable findings of the current study revealed the indirect effect of SCQM on SCP through SCA and SCI. These results broaden the work of previous studies which identified the positive effects of SCQM on performance by providing meaningful insights into SCQM's role in promoting SCA and SCI capabilities, which, in turn, further improves SCP.Originality/valueThis study addresses a gap in the literature concerning the effect of SCQM on SCP. In addition, it is the first study, to the best of the researchers' knowledge, to explore the role of two major SC capabilities, namely, SCA and SCI on the SCQM–SCP relationship. Moreover, the present study addresses a questionable issue in the literature regarding practices that conceptualize SCQM. Several studies confuse SCQM practices with internal quality management (QM) practices. This study defines SCQM as consisting of collaborative QM practices with external SC members and proposes five related practices for measuring SCQM.
Drones to the rescue? Exploring rescue workers' behavioral intention to adopt drones in mountain rescue missions
Authors: Holzmann Patrick , Wankmüller Christian , Globocnik Dietfried , Schwarz Erich J. 
Published: April 2021

PurposeMountaineering and related activities are increasingly becoming popular and are accompanied by an increase in medical incidents. Emergency operations in mountainous terrain are time-critical and often pose major logistical challenges for rescuers. Drones are expected to improve the operational performance of mountain rescuers. However, they are not yet widely used in mountain rescue missions. This paper examines the determinants that drive the behavioral intention of mountain rescuers to adopt drones in rescue missions.Design/methodology/approachThis is a behavioral study that builds upon an extended model of the unified theory of acceptance and use of technology (UTAUT) and investigates the relationship between individual attitudes, perceptions, and intentions for drone adoption. Original survey data of 146 mountain rescuers were analyzed using moderated ordinary least squares (OLS) regression analysis.FindingsResults indicate that the behavioral intention to use drones in mountain rescue missions is driven by the expected performance gains and facilitating conditions. Favorable supporting conditions and experience with drones further moderate the relationship between performance expectancy and behavioral intention. The effects for effort expectancy, social influence, and demonstrations were not significant.Practical implicationsRescue organizations and stakeholders are recommended to consider the identified determinants in the implementation of drones in emergency logistics. Drone manufacturers targeting mountain rescue organizations are advised to focus on operational performance, provide sufficient support and training, and promote the gathering of practical experience.Originality/valueA tailored-model that provides first empirical results on the relevance of personal and environmental factors for the acceptance of drones in emergency logistics is presented.
Sustainability evaluation of service supply chains: a case study of an Indian hospital
Authors: Nagariya Ramji , Kumar Divesh , Kumar Ishwar 
Published: April 2021

PurposeIncreasing pressure from the stakeholders makes the inclusion and evaluation of sustainable practices in the service supply chain (SSC) inevitable. Therefore, this paper aims to evaluate the sustainability status of a case organization and discover the barrier to sustainability in the SSC.Design/methodology/approachFrom the literature review, five sustainability dimensions, seventeen attributes and sixty-five subattributes of the SSC are identified. A three-level conceptual model drawn on human perception is developed. The overall sustainability status of the SSC is determined by using the multigrade fuzzy logic approach. The fuzzy concept incorporated helps in overcoming the challenges of vagueness and impreciseness in the responses. The case SSC is a WestIndia–based hospital.FindingsThe study evaluates the case hospital to be “very sustainable” but far from the “extremely sustainable” level. Six barriers are identified which are reduction in solid waste, compliance with applicable environmental laws and regulations, water usage efficiency, training and education of employees, return on investment and safety equipment for employees. These barriers hinder the hospital from achieving an “extremely sustainable” level.Practical implicationsThis paper evaluates, helps the management in identifying the barriers and thus enabling them to work upon these barriers and achieve a greater level of sustainability.Originality/valueThe sustainability practices adopted in this paper for the evaluation of the sustainability status of the SSC have not been used in previous studies. In this study apart from environmental, social and economic aspects, customer management and health, safety and risk management are also incorporated for evaluating the performance of the SSC which makes this study unique. The proposed model can be taken as a benchmark for evaluating the sustainability performance of any SSC.