bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of a high‐performance liquid chromatography method for urinary oxalate determination and investigation regarding the pediatric reference interval of spot urinary oxalate to creatinine ratio for screening of primary hyperoxaluria
Authors: Shen Ying , Luo Xia , Li Huijun , Guan Qing , Cheng Liming 
Published: June 2021

AbstractBackgroundUrinary oxalate can provide important clues for the screening and monitoring of children with primary hyperoxaluria (PH), which is a potentially life‐threatening condition. However, little effort has been devoted to improve the oxalate assay in recent years. We have proposed a reliable and cost‐effective high‐performance liquid chromatography (HPLC) method for urinary oxalate determination.MethodsUrine specimens were centrifuged after one‐step derivatization, and the supernatants were subjected to HPLC analysis.ResultsThe method was validated with consistent linearity from 0.0625 to 2.0 mmol/L with coefficients of variation ≤7.73%, good recovery, low carryover, satisfactory sample stability, and analytical specificity. The lower limit of quantification and the limit of detection were 0.03130 and 0.0156 mmol/L, respectively. Imprecision values were ≤2.92% and ≤16.6% for externally and internally produced controls, respectively. The pediatric reference interval of spot urinary oxalate to creatinine ratios was established together with its application in screening of PH in patients with renal diseases, revealing its successful deployment in our laboratory.ConclusionsThis reliable HPLC method could serve as a significant tool to determine urinary oxalate levels for screening and monitoring of children with PH in routine clinical laboratories.
One‐pot synthesis of new functionalized 4H‐chromen‐4‐ylidene derivatives
Authors: Saeni Vosough , Bayat Mohammad , Hosseini Fahimeh Sadat 
Published: June 2021

AbstractA simple synthesis of new series of functionalized chromene derivatives through an efficient, one‐pot, multicomponent reaction of nitroketene N,S‐acetals, salicylaldehydes, and cyanoacetohydrazide in ethanol at ambient temperature in good to high yields is reported. This novel efficient method has the advantages of mild reaction conditions, absence of catalyst, simple work‐up, and the non‐chromatographic purification of products.
Integration of patient‐centered care in nutrition support decision‐making: A case report
Authors: Wedemire Courtney , Brody Rebecca , Ganzer Heidi 
Published: June 2021

AbstractPatient‐centered care considers a patient's unique needs, values, preferences, and the psychosocial situation at the heart of decisions related to healthcare. Dietitians have reported several barriers to the practice of patient‐centered care, including a lack of time and support and a perception that patients are unable to participate. This is meaningful as decisions regarding nutrition therapy, specifically in adult populations with cancer, influence patient morbidity and mortality and a patient's quality of life. Patient‐centered care is associated with improved decision‐making, patient‐provider communication, and quality of life in patients with cancer. This case report discusses and applies patient‐centered care in conjunction with the best available evidence for an adult patient with a history of head and neck cancer admitted to a critical care unit. Nutrition support clinicians are equipped to use a patient‐centered and evidence‐based approach to help patients navigate through nutrition therapy decisions that may influence both clinical and quality of life outcomes. Further research should be done to determine the association between patient‐centered care and quality of life outcomes in nutrition support practice.
Dexamethasone-Sparing Regimens with Oral Netupitant and Palonosetron for the Prevention of Emesis Caused by High-Dose Cisplatin: A Randomized Noninferiority Study
Authors: Celio Luigi , Cortinovis Diego , Cogoni Alessio Aligi , Cavanna Luigi , Martelli Olga , Carnio Simona , Collovà Elena , Bertolini Federica , Petrelli Fausto , Cassano Alessandra , Chiari Rita , Zanelli Francesca , Pisconti Salvatore , Vittimberga Isabella , Letizia Antonietta , Misino Andrea , Gernone Angela , Bonizzoni Erminio , Pilotto Sara , De Placido Sabino , Bria Emilio 
Published: June 2021

Abstract

Background
To reduce the overall exposure to dexamethasone (DEX) in patients receiving cisplatin-based chemotherapy, we evaluated the noninferiority of DEX on day 1, with or without low-dose DEX on days 2 and 3, combined with an oral fixed-dose combination of netupitant and palonosetron (NEPA), compared with the guideline-consistent use of 4-day DEX.

Patients and Methods
In this open-label, multicenter study, chemotherapy-naïve patients undergoing high-dose cisplatin (≥70 mg/m2), were given NEPA and DEX (12 mg) on day 1 and randomized (1:1:1 ratio) to receive either (a) no further DEX (DEX1), (b) oral DEX (4 mg daily) on days 2–3 (DEX3), or (c) DEX (4 mg twice daily) on days 2–4 (DEX4). The primary efficacy endpoint was complete response (CR: no emesis and no rescue medication) during the 5-day overall phase. The noninferiority margin was set at −15% difference (DEX1 or DEX3 minus DEX4). Secondary efficacy endpoints included complete protection (CP: CR and none or mild nausea).

Results
Two-hundred twenty-eight patients, 76 in each arm, were assessable. Noninferiority was met for both DEX-sparing regimens and the reference arm, with overall phase CR rates of 76.3% in each of the DEX1 and DEX3 arms and 75.0% in the DEX4 arm (95% confidence interval, −12.3% to 15% for each comparison). During the overall phase, CP rates were similar between groups.

Conclusion
A simplified regimen of NEPA plus single-dose DEX offers comparable chemotherapy-induced nausea and vomiting prevention throughout 5 days post-chemotherapy with the advantage of sparing patients additional doses of DEX in the high–emetic-risk setting of cisplatin-based chemotherapy.

Implications for Practice
Dexamethasone (DEX) has traditionally played an integral role in the management of chemotherapy-induced emesis. Although generally considered safe, even short-term DEX use is associated with various side effects, and some evidence suggests that concurrent steroids may reduce the efficacy of immunotherapies. This study demonstrates comparable antiemetic control during the 5 days post-chemotherapy with a simplified regimen of netupitant/palonosetron plus single-dose DEX versus the standard 4-day DEX reference treatment in high-dose cisplatin. This represents a clinically relevant achievement as it not only simplifies antiemetic prophylaxis but also offers an opportunity to appropriately use in patients where caution with corticosteroid use is advised.
Compression‐after‐impact properties of carbon fiber composites with interlays of Aramid pulp micro‐/nanofibers
Authors: Ye Mingxin , Yuan Bingyan , Hu Yunsen , Hu Xiaozhi 
Published: June 2021

AbstractThe inherent resin‐rich ply interfaces in laminar carbon fiber reinforced polymer (CFRP) composites are toughened by ultrathin interlays formed by Aramid pulp (AP) micro‐/nanofibers, to show that stronger and more impact‐resistant CFRP can be manufactured with minimum disruption to the current composite forming process. Flexible nonwoven AP micro‐/nano‐fibers, less than 1 mm in length, can conveniently fit in the uneven surface profiles or microresin‐rich areas between carbon fiber plies and form in situ quasi‐Z‐directional fiber‐bridging across the ply interfaces. CFRPs with multiple interfacial AP interlays estimated to be around 3 and 6 g/m2 were tested before and after low energy impact. Ultrathin resin‐rich ply‐interface layers in plain CFRP were transformed into ultrathin “Short Aramid Fiber Epoxy” layers by the AP interlays (20–50 μm in thickness), leading to enhanced compressive energy absorption and up to 86.7% increase in Compression‐After‐Impact Strength. Keeping the interlay thin (around 30 μm or thinner if possible), even the compressive strength (without impact) is not compromised, and the energy absorption under compressive loading (without impact) is 130% higher. The distinctly different compressive failure mechanisms, delamination failure of the plain CFRP was transformed into matrix shear failure in AP‐toughened CFRP, as identified by nondestructive X‐ray microcomputed tomography scans. Scanning electron microscopy was performed on the failure surface to inspect the microscopic toughening mechanisms.
ZIF‐8 Derived ZnO Decorated with Polydopamine and Au Nanoparticles for Efficient Photocatalytic Degradation of Rhodamine B
Authors: Zhang Zijun , Li Mei , Wang Hua 
Published: June 2021

AbstractThe drawbacks of low utilization efficiency of solar energy and high recombination rate of photogenerated charge carriers limit the application of ZnO in photocatalytic reaction. In this study, a novel photocatalyst of ZnO decorated with polydopamine (PDA) and Au nanoparticles was successfully fabricated, using zeolite imidazolate frameworks (ZIF‐8) as ZnO precursor, followed by decorating with PDA and Au nanoparticles. The photocatalytic performance in degradation of rhodamine B (RhB) demonstrated that ZnO@PDA‐Au‐3 exhibited the most excellent photocatalytic activity. It could degrade 99 % of RhB in 24 min under UV‐vis light irradiation, in contrast with the degradation rate of 40 % and 16 % on ZnO@PDA and ZnO, respectively. The excellent catalytic activity was attributed to the contribution of PDA and Au. Particularly, Au not only promoted the absorption of visible light through localized surface plasmonic resonance (LSPR) effect, but also effectively facilitated the separation of photogenerated charge carriers though the Schottky barrier.
The Role of a Nitro Substituent in C‐Phenylcalix[4]resorcinarenes to Enhance the Adsorption of Gold(III) Ions
Authors: Priyangga Krisfian Tata Aneka , Kurniawan Yehezkiel Steven , Yuliati Leny 
Published: June 2021

AbstractNitro‐substituted C‐phenylcalix[4]resorcinarene derivatives were synthesized and evaluated for gold(III) ions adsorption. All the nitro‐substituted C‐phenylcalix[4]resorcinarenes showed higher maximum adsorption capacity as compared to the bare C‐phenylcalix[4]resorcinarene. A remarkable high adsorption capacity of up to 272.70 mg g−1 was obtained after 2 h on the C‐2‐nitrophenylcalix[4]resorcinarene (Calix‐2NO2), which was two times higher than that of the C‐phenylcalix[4]resorcinarene. The adsorption capacity was affected by the position of the nitro group. The highest adsorption capacity observed on the Calix‐2NO2 was closely related to the strongest supramolecular interactions between the gold(III) ions and the Calix‐2NO2, as supported by Fourier transform infrared (FTIR) and proton nuclear magnetic resonance (1H‐NMR) spectroscopies as well as the desorption study. This study demonstrated that the macrocyclic material, namely nitro‐substituted C‐phenylcalix[4]resorcinarenes, were effective adsorbents having good reusability, and thus, applicable for gold(III) ions recovery.
Three Luminescent Dinuclear Copper(I) Complexes with P˄N Ligands: Synthesis, Photophysical Properties, DFT Calculations and AIE Behavior
Authors: Dou Shao‐Bin , Xiao Lu , Li Fan , Zhang Yi‐Zheng , Lu Xue , Yang Jian‐Ming , Yang Jie , Wu Min , Niu Zhi‐Gang , Li Gao‐Nan 
Published: June 2021

AbstractThree new BPTA‐bridged binuclear copper(I) complexes bearing three different diphosphine ligands, namely, [(CuI)2(Xantphos)2(BPTA)](BF4)2 (Cu1), [(CuI)2(Dppp)2(BPTA)](BF4)2 (Cu2), and [(CuI)2(Binap)2(BPTA)](BF4)2 (Cu3), have been synthesized and characterized. The X‐ray structure analyses of complex Cu3 show that the central copper(I) ion adopts a distorted tetrahedral geometry. Complexes Cu1 and Cu2 exhibit greenish‐yellow emission with excited‐state lifetime (13μs and 27μs) and photoluminescence quantum yields (6.86 % and 0.62 %) at room temperature in the solid state. Emission decay measurement and theoretical calculation suggest that the transition nature of their emission could be assigned to 3MLCT/3LC excited states. More interesting, complexes Cu1‐Cu3 are weakly emissive in solution but become strongly luminescent in solid state, so it has the aggregation induced emission (AIE) behavior.
Current status and limitations of artificial intelligence in colonoscopy
Authors: Hann Alexander , Troya Joel , Fitting Daniel 
Published: June 2021

AbstractBackgroundArtificial intelligence (AI) using deep learning methods for polyp detection (CADe) and characterization (CADx) is on the verge of clinical application. CADe already implied its potential use in randomized controlled trials. Further efforts are needed to take CADx to the next level of development.AimThis work aims to give an overview of the current status of AI in colonoscopy, without going into too much technical detail.MethodsA literature search to identify important studies exploring the use of AI in colonoscopy was performed.ResultsThis review focuses on AI performance in screening colonoscopy summarizing the first prospective trials for CADe, the state of research in CADx as well as current limitations of those systems and legal issues.
Efficient Metal‐free ZIF‐8 Derived B, N‐codoped Carbon Electrocatalyst toward Oxygen Reduction
Authors: Li Wei‐Si , Sun Zhi‐Yuan , Yang Jin‐Meng , Huang Gao‐Yuan , Zhu Hai‐Bin 
Published: June 2021

AbstractMetal‐free carbon materials doped with multiple nonmetal heteroatoms (e. g. N, B, S, P) have emerged as a promising class of electrocatalysts toward oxygen reduction reaction (ORR). Herein, B, N‐codoped carbon electrocatalysts are conveniently prepared by use of ZIF‐8 precursor, which involves cage‐encapsulation of PhB(OH)2 before high‐temperature pyrolysis. By modulating the B‐doping amount and pyrolysis temperature, an optimal B, N‐codoped carbon electrocatalyst toward ORR is achieved, which shows ORR activity (Eonset=0.95 V, and E1/2=0.83 V vs RHE) comparable to the Pt/C benchmark, with a good methanol tolerance and long‐term stability.
Correlation functions in finite temperature CFT and black hole singularities
Authors: Rodriguez-Gomez D. , Russo J.G. 
Published: June 2021

Abstract
We compute thermal 2-point correlation functions in the black brane AdS5 background dual to 4d CFT’s at finite temperature for operators of large scaling dimension. We find a formula that matches the expected structure of the OPE. It exhibits an exponentiation property, whose origin we explain. We also compute the first correction to the two-point function due to graviton emission, which encodes the proper time from the event horizon to the black hole singularity.
Versorgungsforschung in der Zahnmedizin in Deutschland
Authors: Huettig Fabian , Schwendicke Falk 
Published: June 2021

ZusammenfassungIn den letzten 8 Jahren wurde in Deutschland nicht nur „mehr Versorgungsforschung in der Zahnmedizin“ gefordert, sondern auch geleistet. Insgesamt finden sich an 12 Medizinischen Fakultäten themenbezogene Aktivitäten der Zahn‑, Mund- und Kieferheilkunde in der Versorgungsforschung; deutschlandweit werden 9 Großprojekte verortet, die vom Bundesministerium für Bildung und Forschung oder vom Innovationsfonds gefördert werden. Gleichwohl ist der Bedarf an Versorgungsforschung größer als die jetzige Leistungsfähigkeit der universitären und außeruniversitären Zahnmedizin: Um eine nachhaltige, bedarfsgerechte und zukunftssichere zahnärztliche Versorgung aller Menschen in Deutschland gewährleisten zu können, bedarf es strukturierter, methodisch versierter und in die Versorgung hinein vernetzter Verbünde, die das wissenschaftliche Fundament für erwartete Versorgungsumbrüche legen können.Der vorliegende Beitrag soll den Stand der Versorgungsforschung in der Zahn‑, Mund- und Kieferheilkunde in Deutschland beschreiben. Die wesentlichen Herausforderungen werden adressiert: Methodenkompetenz, Zugang zu Daten und deren Nutzung sowie die langfristige Perspektive dieses Forschungsbereichs. Derzeitige Forschungsaktivitäten und Infrastruktur inklusive Förder- und Fortbildungsinstrumente werden dargestellt.Die Erkenntnisse aus der zahnärztlichen Versorgungsforschung in Deutschland können auch für andere Länder richtungsweisend sein; umgekehrt kann Versorgungsforschung Ansätze aus anderen Ländern sinnvoll in das deutsche Gesundheitssystem übertragen. Versorgungsforschende sollten sich professionalisieren und vernetzen. Nachhaltige Strukturen (Professuren, Mittelbau) und Rahmenbedingungen (Datennutzung, Förderung) sollten geschaffen und Forschungsergebnisse zeitnah verwertet werden.
Safety and efficacy of polydimethylsiloxane (Macroplastique®) in women with stress urinary incontinence: analysis of data from patients who completed three years follow-up
Authors: Ghoniem Gamal , Farhan Bilal , Chowdhury Mashrin Lira , Chen Yanjun 
Published: June 2021

Abstract
Introduction and hypothesis
This study aimed to report 3-year completed follow-up of the safety and efficacy of Macroplastique® (MPQ) in women with stress urinary incontinence (SUI) due to intrinsic sphincter deficiency (ISD).

Methods
This is a retrospective analysis of all women who completed 3-year follow-up post-MPQ injection(s) at ten medical centers. We used the ROSE registry data report of Macroplastique® [Macroplastique® Real-time Observation of Safety and Effectiveness (ROSE) registry P040050/PAS001 on 2017]. Subjective incontinence outcome and adverse effects were assessed.

Results
The study included all patients (n = 70) who completed 3-year follow-up after the last MPQ injection. Twenty-four of 70 (34%) patients had two injections; 21/70 (30%) patients reported Stamey grade 0 and 28/70 (40%) reported Stamey grade 1. The overall patient satisfaction was 68% who completed 3-year follow-up. The composite success rate (I-QoL, PGI-S, and Stamey grade improvement) was 51.4%. No serious adverse events (AE) were reported within the completed 3-year follow-up.

Conclusions
MPQ was found to be safe and efficacious for the treatment of SUI secondary to ISD in women. The overall high satisfaction rate was sustained from baseline to 3 years post-injection. Most complications were minor and transient without sequelae.
Existence and non-existence for time-dependent mean field games with strong aggregation
Authors: Cirant Marco , Ghilli Daria 
Published: June 2021

AbstractWe investigate the existence of classical solutions to second-order quadratic Mean-Field Games systems with local and strongly decreasing couplings of the form$$-\sigma m^\alpha $$-σmα,$$\alpha \ge 2/N$$α≥2/N, wheremis the population density andNis the dimension of the state space. We prove the existence of solutions under the assumption that$$\sigma $$σis small enough. For large$$\sigma $$σ, we show that existence may fail whenever the time horizonTis large.
The Resurgent Structure of Quantum Knot Invariants
Authors: Garoufalidis Stavros , Gu Jie , Mariño Marcos 
Published: June 2021

AbstractThe asymptotic expansion of quantum knot invariants in complex Chern–Simons theory gives rise to factorially divergent formal power series. We conjecture that these series are resurgent functions whose Stokes automorphism is given by a pair of matrices of q-series with integer coefficients, which are determined explicitly by the fundamental solutions of a pair of linear q-difference equations. We further conjecture that for a hyperbolic knot, a distinguished entry of those matrices equals to the Dimofte–Gaiotto–Gukov 3D-index, and thus is given by a counting of BPS states. We illustrate our conjectures explicitly by matching theoretically and numerically computed integers for the cases of the $$4_1$$

4
1

and the $$5_2$$

5
2

knots.
In situ high-temperature behaviour of fluor-elbaite: breakdown conditions and products
Authors: Celata Beatrice , Ballirano Paolo , Andreozzi Giovanni B. , Bosi Ferdinando 
Published: June 2021

AbstractThe thermal behaviour of a fluor-elbaite from Minas Gerais (Brazil) was investigated at room pressure through in situ high-temperature X-ray powder diffraction (HT-XRPD), until the breakdown conditions were reached. The variations of fluor-elbaite structural parameters (unit-cell parameters and mean bond distances) were monitored together with site occupancies, and two main internal reactions were identified: the thermally-induced Fe oxidation process counterbalanced by (OH)–deprotonation, which starts at 500 °C (773 K), followed by a partial intracrystalline Fe–Al exchange between the octahedrally-coordinatedYandZsites. The fluor-elbaite breakdown reaction occurs between 850 °C (1123 K) and 900 °C (1173 K). The breakdown products were identified at room temperature by XRPD and the breakdown reaction can be described by the following reaction: tourmaline → B-bearing mullite + hematite + spinel + B-poor (Na, Li, H2O)-bearing glass. Boromullite itself was not observed in the final heating products, and the B-bearing mullite from the breakdown reaction exhibited unit-cell parametersa = 7.5382(2) Å,b = 7.6749(2) Å,c = 2.8385(1) Å,V = 164.22(1) Å3(space groupPbam) consistent with an approximate Al8.5B1.5Si2O19composition.
Politischer Missbrauch in der Psychiatrie der DDR
Authors: Erices Rainer 
Published: June 2021

Zusammenfassung
Hintergrund
Noch immer finden sich in Publikationen Zweifel an Forschungen, die zeigten, dass es in der DDR keinen systematischen und politisch motivierten Missbrauch der Psychiatrie gab. Seit den 1990er-Jahren liegen Ergebnisse von Untersuchungskommissionen und eine detaillierte Auswertung der Stasiakten zu dieser Thematik vor. Nachgewiesen wurde, dass Menschen in der DDR aus politischen Motiven psychiatrisiert wurden – jedoch lediglich in Einzelfällen. Unklar ist bis heute das genaue Ausmaß politischer Psychiatrisierung.

Fragestellung
Welche Forschungslücken bestehen hinsichtlich des mutmaßlichen Missbrauchs der Psychiatrie in der DDR?

Material
Neue Aktenfunde belegen, dass die Behörden in der Bundesrepublik Aussagen über eine Strafpsychiatrie in der DDR sammelten.

Ergebnisse und Schlussfolgerung
Der Bundesnachrichtendienst (BND) ging von einem politischen Missbrauch in der DDR aus. Er stützte sich dabei auf die Aussagen von DDR-Flüchtlingen. Was mit den Erkenntnissen geschah, ist nicht überliefert. Zur Bewertung der Erkenntnisse und auch zur Einschätzung des Ausmaßes psychiatrischen Missbrauchs in der DDR fehlen bis heute Detailanalysen. So gibt es v. a. kaum Studien zur medizinischen Verwaltungsebene. Es fehlen übergreifende Untersuchungen zur Qualität der Ergebnisse psychiatrischer Begutachtung von Regimegegnern oder zur außerklinischen Registrierung von psychisch Kranken in der DDR.
Electroanalysis with a single microbead of phosphate binding resin (FerrIX™) mounted in epoxy film
Authors: Thompson Abigail K. , Mathwig Klaus , Fletcher Philip J. , Castaing Rémi , Marken Frank 
Published: June 2021

AbstractCommercial resin microbeads are widely applied in ion exchange and extraction. Here, a single anion-selective and phosphate binding resin microbead (FerrIX™) is mounted into an epoxy membrane and investigated by 4-electrode membrane voltammetry and membrane impedance spectroscopy. Anion transport properties are observed to dominate associated with three distinct potential domains: (I) a low bias ohmic potential domain (dominant at high electrolyte concentration), (II) a concentration polarisation potential domain, and (III) an over-limiting potential domain. Voltammetric responses show transient diffusion-migration features at higher scan rates and quasi-steady state features at lower scan rates. Inherent microbead conductivity is shown to be linked to two resistive elements, electrolyte concentration dependent and independent, in series. The effects of phosphate binding are revealed as transient pattern in impedance spectroscopy data. Preliminary data suggest phosphate concentration-dependent peak features in the imaginary impedance versus frequency plot due to phosphate binding into the microbead.
Graphical abstract