bluuebunny/crossref_metadata_2025_split huggingface dataset:
Children With Autism Spectrum Disorder Can Attribute False Beliefs in a Spontaneous-Response Preferential-Looking Task
Authors: Glenwright Melanie , Scott Rose M. , Bilevicius Elena , Pronovost Megan , Hanlon-Dearman Ana 
Published: July 2021

An established body of literature indicates that children with autism spectrum disorder (ASD) have difficulty understanding figurative language due to a deficit in theory of mind, or the ability to consider the beliefs of other people. Children with ASD tend to similarly fail traditional theory of mind tasks, which assess their ability to represent false beliefs. Our claim is, however, that these tasks involve cognitive processing demands that might mask false belief understanding because they require elicited responses. We examined whether children with ASD demonstrate false-belief understanding when tested with a spontaneous-response false belief task that measures children’s eye gaze durations. The two child participant groups were composed of 20 males with ASD (aged 3–9 years) and 20 typically developing males (aged 2–5 years) who were individually matched according to verbal mental age. Children with ASD and typically developing children listened to a change-of-location story accompanied by a book with matching and non-matching pictures. The final page showed the character searching for her object in a location that was either consistent or inconsistent with her belief. Both groups of children looked reliably longer at the belief-consistent picture, regardless of whether the character’s belief was true or false, though children with ASD were slower to do so. We suggest that a spontaneous-response assessment technique can potentially reveal figurative language comprehension in children with ASD in future research.
Uncovering Potential lncRNAs and mRNAs in the Progression From Acute Myocardial Infarction to Myocardial Fibrosis to Heart Failure
Authors: Wang Shuo , Wang Enmao , Chen Qincong , Yang Yan , Xu Lei , Zhang Xiaolei , Wu Rubing , Hu Xitian , Wu Zhihong 
Published: July 2021

Background: Morbidity and mortality of heart failure (HF) post-myocardial infarction (MI) remain elevated. The aim of this study was to find potential long non-coding RNAs (lncRNAs) and mRNAs in the progression from acute myocardial infarction (AMI) to myocardial fibrosis (MF) to HF.Methods: Firstly, blood samples from AMI, MF, and HF patients were used for RNA sequencing. Secondly, differentially expressed lncRNAs and mRNAs were obtained in MF vs. AMI and HF vs. MF, followed by functional analysis of shared differentially expressed mRNAs between two groups. Thirdly, interaction networks of lncRNA-nearby targeted mRNA and lncRNA-co-expressed mRNA were constructed in MF vs. AMI and HF vs. MF. Finally, expression validation and diagnostic capability analysis of selected lncRNAs and mRNAs were performed.Results: Several lncRNA-co-expressed/nearby targeted mRNA pairs including AC005392.3/AC007278.2-IL18R1, AL356356.1/AL137145.2-PFKFB3, and MKNK1-AS1/LINC01127-IL1R2 were identified. Several signaling pathways including TNF and cytokine–cytokine receptor interaction, fructose and mannose metabolism and HIF-1, hematopoietic cell lineage and fluid shear stress, and atherosclerosis and estrogen were selected. IL1R2, IRAK3, LRG1, and PLAC4 had a potential diagnostic value for both AMI and HF.Conclusion: Identified AC005392.3/AC007278.2-IL18R1, AL356356.1/AL137145.2-PFKFB3, and MKNK1-AS1/LINC01127-IL1R2 lncRNA-co-expressed/nearby targeted mRNA pairs may play crucial roles in the development of AMI, MF, and HF.
Traditional Chinese Medication Qiliqiangxin Attenuates Diabetic Cardiomyopathy via Activating PPARγ
Authors: Wu Xiaodong , Zhang Ting , Lyu Ping , Chen Mengli , Ni Gehui , Cheng Huiling , Xu Guie , Li Xinli , Wang Lijun , Shang Hongcai 
Published: July 2021

Background: Diabetic cardiomyopathy is the primary complication associated with diabetes mellitus and also is a major cause of death and disability. Limited pharmacological therapies are available for diabetic cardiomyopathy. Qiliqiangxin (QLQX), a Chinese medication, has been proven to be beneficial for heart failure patients. However, the role and the underlying protective mechanisms of QLQX in diabetic cardiomyopathy remain largely unexplored.Methods: Primary neonatal rat cardiomyocytes (NRCMs) were treated with glucose (HG, 40 mM) to establish the hyperglycemia-induced apoptosis model in vitro. Streptozotocin (STZ, 50 mg/kg/day for 5 consecutive days) was intraperitoneally injected into mice to establish the diabetic cardiomyopathy model in vivo. Various analyses including qRT-PCR, western blot, immunofluorescence [terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining] histology (hematoxylin–eosin and Masson's trichrome staining), and cardiac function (echocardiography) were performed in these mice. QLQX (0.5 μg/ml in vitro and 0.5 g/kg/day in vivo) was used in this study.Results: QLQX attenuated hyperglycemia-induced cardiomyocyte apoptosis via activating peroxisome proliferation-activated receptor γ (PPARγ). In vivo, QLQX treatment protected mice against STZ-induced cardiac dysfunction and pathological remodeling.Conclusions: QLQX attenuates diabetic cardiomyopathy via activating PPARγ.
Inhibition of Extracellular Cathepsin D Reduces Hepatic Lipid Accumulation and Leads to Mild Changes in Inflammationin NASH Mice
Authors: Yadati Tulasi , Houben Tom , Bitorina Albert , Oligschlaeger Yvonne , Gijbels Marion J. , Mohren Ronny , Lütjohann Dieter , Khurana Princy , Goyal Sandeep , Kulkarni Aditya , Theys Jan , Cillero-Pastor Berta , Shiri-Sverdlov Ronit 
Published: July 2021

Background &amp; AimsThe lysosomal enzyme, cathepsin D (CTSD) has been implicated in the pathogenesis of non-alcoholic steatohepatitis (NASH), a disease characterised by hepatic steatosis and inflammation. We have previously demonstrated that specific inhibition of the extracellular CTSD leads to improved metabolic features in Sprague-Dawley rats with steatosis. However, the individual roles of extracellular and intracellular CTSD in NASH are not yet known. In the current study, we evaluated the underlying mechanisms of extracellular and intracellular CTSD fractions in NASH-related metabolic inflammation using specific small-molecule inhibitors.MethodsLow-density lipoprotein receptor knock out (Ldlr-/-) mice were fed a high-fat, high cholesterol (HFC) diet for ten weeks to induce NASH. Further, to investigate the effects of CTSD inhibition, mice were injected either with an intracellular (GA-12) or extracellular (CTD-002) CTSD inhibitor or vehicle control at doses of 50 mg/kg body weight subcutaneously once in two days for ten weeks.ResultsLdlr-/- mice treated with extracellular CTSD inhibitor showed reduced hepatic lipid accumulation and an associated increase in faecal bile acid levels as compared to intracellular CTSD inhibitor-treated mice. Furthermore, in contrast to intracellular CTSD inhibition, extracellular CTSD inhibition switched the systemic immune status of the mice to an anti-inflammatory profile. In line, label-free mass spectrometry-based proteomics revealed that extra- and intracellular CTSD fractions modulate proteins belonging to distinct metabolic pathways.ConclusionWe have provided clinically translatable evidence that extracellular CTSD inhibition shows some beneficial metabolic and systemic inflammatory effects which are distinct from intracellular CTSD inhibition. Considering that intracellular CTSD inhibition is involved in essential physiological processes, specific inhibitors capable of blocking extracellular CTSD activity, can be promising and safe NASH drugs.
A Potential circRNA-miRNA-mRNA Regulatory Network in Asthmatic Airway Epithelial Cells Identified by Integrated Analysis of Microarray Datasets
Authors: Chen Dian , Wu Wenliang , Yi Lingling , Feng Yuchen , Chang Chenli , Chen Shengchong , Gao Jiali , Chen Gongqi , Zhen Guohua 
Published: July 2021

Background: Asthma is one of the most prevalent chronic respiratory diseases worldwide. Bronchial epithelial cells play a critical role in the pathogenesis of asthma. Circular RNAs (circRNAs) act as microRNA (miRNA) sponges to regulate downstream gene expression. However, the role of epithelial circRNAs in asthma remains to be investigated. This study aims to explore the potential circRNA-miRNA-messenger RNA (mRNA) regulatory network in asthma by integrated analysis of publicly available microarray datasets.Methods: Five mRNA microarray datasets derived from bronchial brushing samples from asthma patients and control subjects were downloaded from the Gene Expression Omnibus (GEO) database. The robust rank aggregation (RRA) method was used to identify robust differentially expressed genes (DEGs) in bronchial epithelial cells between asthma patients and controls. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were used to annotate the functions of the DEGs. Protein-protein interaction (PPI) analysis was performed to identify hub genes. Three miRNA databases (Targetscan, miRDB, and miRWalk) were used to predict the miRNAs which potentially target the hub genes. A miRNA microarray dataset derived from bronchial brushings was used to validate the miRNA-mRNA relationships. Finally, a circRNA-miRNA-mRNA network was constructed via the ENCORI database.Results: A total of 127 robust DEGs in bronchial epithelial cells between steroid-naïve asthma patients (n = 272) and healthy controls (n = 165) were identified from five mRNA microarray datasets. Enrichment analyses showed that DEGs were mainly enriched in several biological processes related to asthma, including humoral immune response, salivary secretion, and IL-17 signaling pathway. Nineteen hub genes were identified and were used to construct a potential epithelial circRNA-miRNA-mRNA network. The top 10 competing endogenous RNAs were hsa_circ_0001585, hsa_circ_0078031, hsa_circ_0000552, hsa-miR-30a-3p, hsa-miR-30d-3p, KIT, CD69, ADRA2A, BPIFA1, and GGH.Conclusion: Our study reveals a potential role for epithelial circRNA-miRNA-mRNA network in the pathogenesis of asthma.
Initial Experience With the Trevo NXT Stent Retriever
Authors: Etter Manina M. , Möhlenbruch Markus , Weyland Charlotte S. , Pérez-García Carlos , Moreu Manuel , Capasso Francesco , Limbucci Nicola , Nikoubashman Omid , Wiesmann Martin , Blackham Kristine , Tsogkas Ioannis , Sporns Peter , Ospel Johanna Maria , Brehm Alex , Psychogios Marios-Nikos 
Published: July 2021

Background: The application of a new coating to the delivery wire of the Trevo retriever has the potential to improve its handling. We therefore report our initial experience with this new stent retriever for mechanical thrombectomy of large and medium vessel occlusions.Methods: We pooled data of four high-volume European stroke centers over the time period from October 2020 to February 2021. Patients were included in our study if the Trevo NXT stent retriever was used as a first-line device. Primary endpoints were first-pass near-complete or complete reperfusion, defined as mTICI score of ≥2c. Secondary endpoints were final reperfusion, National Institutes of Health Stroke Scale (NIHSS) at 24 h and discharge, device malfunctions, complications during the procedure, and subjective ratings of the interventionalists regarding device functionality.Results: Eighty patients (39 women, mean age 74 ± 14 years) were eligible for our study. Median NIHSS at admission was 15 (IQR, 8–19), and median Alberta Stroke Program Early CT Score at baseline was 9 (IQR, 8–10). In 74 (93%) patients a primary combined approach was used as first-line technique. First-pass near-complete reperfusion was achieved in 43 (54%) and first-pass complete reperfusion in 34 (43%) patients. Final near-complete reperfusion was achieved in 66 (83%) patients after a median of 1.5 (1–3) passes, while final successful reperfusion was observed in 96% of our cases. We observed no device malfunctions. Median NIHSS at discharge was 2 (IQR, 0–5), and 3 patients (4%) suffered a symptomatic intracranial hemorrhage.Conclusions: Based on our initial data, we conclude that the Trevo NXT is an effective and safe tool for mechanical thrombectomy especially when used for combined approaches.
Endovascular Treatment of Posterior Circulation Saccular Aneurysms With the p64 Flow Modulation Device: Mid-and Long-Term Results in 54 Aneurysms From a Single Center
Authors: Hellstern Victoria , Aguilar-Pérez Marta , Henkes Elina , Serna-Candel Carmen , Wendl Christina , Bäzner Hansjörg , Ganslandt Oliver , Henkes Hans 
Published: July 2021

Objective: Flow diverter (FD) stents have become one of the most common tools for treating intracranial aneurysms; however, their role in treating posterior circulation aneurysms is still discussed with controversy. In this study, we evaluated the safety and effectiveness of p64 FD for the treatment of saccular, unruptured aneurysms in the posterior circulation over a long-term follow-up period in a single center.Methods: From our prospectively maintained database, we retrospectively identified patients who underwent treatment of an intracranial saccular aneurysm arising from the posterior circulation with ≥1 p64 FD implanted or attempted between October 2012 and December 2019. Aneurysms could have been treated with prior or concomitant saccular treatment (e.g., coiling, intra-aneurysmal flow diversion). Aneurysms with parent vessel implants other than p64, fusiform aneurysms, and dissections were excluded. Peri- and postprocedural complications, clinical outcome, and clinical and angiographic follow-up results were evaluated.Results: In total, 54 patients (45 female, 9 male; mean age 55.1 years) with 54 intracranial aneurysms met the inclusion criteria. In 51 cases (94.4%), one p64 was implanted; in 2 cases (3.7 %), two p64s were implanted; in one case, deployment of the p64 was not feasible. Procedural complications occurred in 3.7% and postprocedural complications in 9.3 %, respectively. Hemorrhagic complications occurred in 2/54 patients (3.7%), thereof one fatal parenchymal hemorrhage. Ischemic complications were observed in 5/54 patients (9.3%). Early, mid-term, and long-term angiographic follow-up examinations showed complete or near-complete aneurysm occlusion, defined according to the O'Kelly –Marotta (OKM) scale as OKM C + D in 56, 75.6, and 82.9 %, respectively. Asymptomatic side vessel occlusions occurred in 3.8%, each during the first follow-up.Conclusions: The implantation of a p64 FD is a safe and effective device for endovascular treatment of posterior circulation saccular aneurysms with a high success rate and low morbi-mortality.
The Effect of Cerebral Small Vessel Disease on the Subtypes of Mild Cognitive Impairment
Authors: Li Xudong , Shen Miaoxin , Jin Yi , Jia Shuhong , Zhou Zhi , Han Ziling , Zhang Xiangfei , Tong Xiaopeng , Jiao Jinsong 
Published: July 2021

Objectives: Cerebral small vessel disease (CSVD) is the most common vascular cause of dementia, and mild cognitive impairment (MCI) is an intermediate state between dementia and normal cognitive aging. The present study investigated the main imaging features of CSVD on different MCI subtypes in memory clinics.Methods: A total of 236 patients with MCI and 85 healthy controls were included. One hundred nine amnestic MCI-multiple domains (amMCI), 38 amnestic MCI-single domain (asMCI), 36 non-amnestic MCI-multiple domains (namMCI), and 53 non-amnestic MCI-single domain (nasMCI) patients were diagnosed. All participants were evaluated with the cognitive assessments and imaging features including white matter hyperintensity (WMH), enlarged perivascular spaces (EPVS), cerebral microbleeds (CMBs), and cerebral atrophy according to a standard procedure.Results: The patients with amMCI, namMCI, and nasMCI had more high-grade basal ganglia EPVS compared with healthy controls, while the percentages of high-grade basal ganglia EPVS in the patients with amMCI were also more than those in patients with asMCI, namMCI, and nasMCI. There were more high-grade centrum semiovale EPVS in patients with amMCI in comparison with all other groups. The patients with amMCI and namMCI had more percentages of severe deep and periventricular WMH and deep CMBs compared with healthy controls. All MCI groups had higher scores of the medial temporal lobe atrophy than healthy controls, whereas the scores of the amMCI group were also higher than those of the namMCI and nasMCI groups.Conclusions: There were varied neuroimaging features of CSVD including cerebral atrophy in different MCI groups, which meant that vascular mechanism contributed to the prodromal stage of dementia.
Membangun Branding Logo Wisata Sejarah Sumatera Barat
Authors: Muhammad Rio Akbar  , Riki Iskandar  , Abulwafa Muhammad  
Published: July 2021

Pemerintah Sumatera Barat Saat ini sedang mengembangkan diri sebagai salah satu destinasi
wisata di dunia, terlebih saat Sumatera Barat berhasil memenangkan beberapa Item dalam kompetisi Destinasi Wisata Halal Dunia. Keunikan masyarakat, budaya, keindahan alam dan keragaman kuliner menjadi andalan pemerintah dalam memajukan sektor pariwisata. Sumatera Barat juga didukung oleh keragaman warisan budaya masa lalu / wisata sejarah, yang memiliki potensi besar untuk dikembangkan. Penelitian ini dilakukan untuk menganalisa kondisi branding promosi wisata sejarah Sumatera Barat yang telah ada saat ini, didukung dengan konsep branding Desain Komunikasi Visual. Penelitian ini diharapkan menemukan berbagaimacam hal yang dapat dijadikan referensi guna mendesain dan membangun branding logo romosi Wisata Sejarah suamtera Barat yang terintegrasi.
San Girolamo ‘gesuato’
Authors: Gianni Alessandra 
Published: July 2021

This essay looks at the specific iconography of saint Jerome in the artistic commissions of the Jesuati during the 15th century. This specific iconography meant to show the Doctor of the Church as the illustrious founder of the congregation in place of Colombini who never was canonized and meant to presents their form of religious life and the rejection of the Holy Orders through the extremely rare illustration of the episode in the life of Saint Jerome: The anticiceroniano dream. The dissemination of this theme was previously attributed to Hieronymites of Fiesole
Peningkatan Motivasi pada Anak Yatim Piatu untuk Mengikuti Jenjang Pendidikan Formal di Yayasan Yatim Piatu Desa Mekarmukti Lampung Timur
Authors: Yanti Fitri April , Anjarwati Sulis , Noperi Hendri , Stiawan Wahyu 
Published: July 2021

Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan motivasi pada anak yatim piatu untuk mengikuti jenjang Pendidikan formal di Yayasan Yatim Piatu Desa Mekarmukti Lampung Timur. Yayasan yatim piatu ini kegiatan kemasyarakaatan yang membina, mendidik, dan mengasuh anak-anak yatim, dan yatim piatu. Pengasuhan pada anak, berakhir saat anak sudah berusia 17 tahun. Hal ini dianggap anak pada usia tersebut sudah baliqh (dewasa) dan dapat bertahan hidup secara mandiri dengan bekerja. Namun, saat ini masih banyak anak yatim yang berhenti sekolah sebelum menempuh wajib belajar yang dicanangkan oleh pemerintah yaitu 12 tahun di jenjang Pendidikan formal. Pentingnya menempuh jenjang Pendidikan formal, agar kelak anak-anak memiliki bekal untuk mendapatkan pekerjaan saat mereka sudah dapat hidup secara mandiri. Peningkatan motivasi pada anak yatim di Yayasan yatim piatu Desa Mekarmukti diperlukan agar anak-anak dapat mengikuti jenjang Pendidikan formal sekurang-kurangnya memenuhi wajib belajar 12 tahun
Pemasangan IUD dan Implant Sebagai Pencegahan Baby Boom Pada Masa Pandemi Covid-19
Authors: Widaryanti Rahayu , Riska Herliana , Ratnaningsih Ester , Yuliani Istri 
Published: July 2021

Tujuan pengabdian masyarakat ini adalah untuk meningkatkan jumlah peserta KB MKJP dengan pemasangan Implant dan IUD. Metode pengabdian ini menggunakan studi lapangan, pemeriksaan langsung dengan langkah kegiatan; Penyuluhan, Pendidikan Kesehatan tentang KB MKJP IUD, Implant dan pemasangan Implant serta IUD. Kgiatan Pengabdian masyarakat dilakukan di wilayah Kabupaten Sleman, dilaksanakan pada Bulan Agustus sampai dengan September 2020. Hasil kegiatan pengabdian kepada masyarakat ini di ikuti oleh 88 akseptor yang terdiri dari 60 akseptor IUD dan 28 akseptor implant. Kegiatan Pengabdian dapat memberikan informasi kepada WUS serta memberikan kontribusi yang besar terhadap peningkatan jumlah peserta KB MKJP ( IUD dan Implant)
Installation of IUDs and Implants as a Baby Boom Prevention During the Covid-19 Pandemic
The purpose of this community service is to increase the number of MKJP family planning participants by installing implants and IUDs. This service method uses field studies, direct examination with activity steps; Counseling, Health Education about KB MKJP IUD, Implants, and the installation of Implants and IUDs. Community service activities are carried out in the Sleman Regency area, carried out from August to September 2020. The results of this community service activity were participated in by 88 acceptors consisting of 60 IUD acceptors and 28 implant acceptors. Service activities can provide information to WUS and make a major contribution to increasing the number of MKJP family planning participants (IUD and Implant).
A case of diagnosis of diffuse large b-cell lymphoma with extranodular cervical disease
Authors: Grigorenko A. A. , Voytsekhovskiy V. V. , Roshchin S. N. 
Published: July 2021

Aim. Demonstration of a case of diagnosing extranodal diffuse large B-cell lymphoma of rare localization – with a massive lesion of the cervix with spread to the body of the uterus and the anterior wall of the vagina.Results. The patient, born in 1991, considers herself ill since December 2020, when watery, bloody discharge from the genital tract first appeared. She went to the gynecologist at the place of residence; upon examination, a malignant neoplasm was suspected. For further examination and treatment, she was sent to the Amur Regional Oncological Dispensary, where a morphological and immunohistochemical study of the biopsy material was performed. In a histological specimen, there is a picture of lymphoma. Immunohistochemical study: tumor cells express CD10, CD20, BCL6, CD23. Tumor cells do not express CD5 (+ on small T-lymphocytes), BCL2 (+ on small T-lymphocytes), CD30, C-MYC, MUM1. When reacting with Ki-67, 90% of tumor cells are positive. The morphoimmunohistochemical picture is characteristic of diffuse large Bcell lymphoma from cells of germ cell centers.Conclusion. Diagnosis of extranodal lymphoma can be very difficult, and the leading role belongs to an experienced morphologist and the availability of modern diagnostics of the variant of lymphoma.
PENYULUHAN TENTANG PENANGGULANGAN TB PARU DAN SANITASI RUMAH SEHAT BAGI PENDERITA TB PARU DI RUMAH SEHAT ALAMI
Authors: Mahyar Suara  , Isnaeni  , Desridiun Kholid  
Published: July 2021

Pendahuluan: Tuberkulosis adalah penyakit menular yang ditularkan oleh bakteri Mycobacterium tuberculosis, penyebab kematian terutama di negara berkembang di seluruh dunia.
Metode: Metode yang digunakan dalam kegiatan pengabdian kepada masyarakat adalah wawancara, pengukuran dan observasi.
Hasil: Keadaan sanitasi rumah sehat yaitu: penerangan 18,2%, ventilasi kelembaban 21,2% (84,8%), lantai (87,9%), kepadatan hunian (84,8%), dapur (100%), jamban (100%), fasilitas air bersih (100%), fasilitas air limbah (100%) dan pengelolaan sampah (100%) yang memenuhi standar
Kesimpulan: Terjadi peningkatan pengetahuan pasien tentang pencegahan TB Paru sebelum dan sesudah diberikan bimbingan dan konseling sebesar 90,9%. Terjadi peningkatan pengetahuan penderita TB paru tentang sanitasi di rumah sehat sebelum dan sesudah diberikan bimbingan dan penyuluhan yaitu sebesar 87,9%.