bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investment location dynamics and influencing factors of pollution‐intensive industries in China: A study of chemical firms
Authors: Wu Yinhao , Miao Changhong , Wei Yehua Dennis , Miao Jianming 
Published: August 2021

AbstractWith rising environmental regulations and trade disputes, Chinese industries are facing tremendous pressures to restructure and relocate, and pollution‐intensive industries (PIIs) are undergoing particularly significant location adjustment. Scholars have proposed various location theories and econometric models to explain the investment location dynamics of PIIs. However, there are still some deficiencies in the analysis of effective factors, such as macroeconomic changes, uneven development, and enterprise heterogeneity. This paper aims to explore the influencing factors of PIIs location choice from multiple dimensions by integrating multiple location factors and incorporating the variables of temporal, spatial, firm heterogeneity and their interaction items into an econometric model. Based on the capacity investment database for Chinese listed chemical companies, we find that: (a) the investment of chemical firms in the central and western regions has significant regional proximity, while the investment in the eastern region shows a significant north‐south difference. (b) The macroeconomic situation measured by the industry climate index has the greatest effect, magnifies the influence of environmental regulation (ER) and expands the differences of investment location preferences between non‐stated‐owned enterprises (non‐SOEs) and state‐owned enterprises (SOEs), due to SOEs’ have undertaken more social responsibilities. (c) The agglomeration economy significantly increases the probability of investment in all regions, especially in the eastern region; non‐SOEs are more inclined to invest in the central and western regions than SOEs. We conclude that PIIs use a location strategy to adapt to the changing environment and that the effect of ER is mediated through ownership structure and local context.
Single centre experience on Acquired Haemophilia A patients: Diagnosis, clinical management and analysis of factors predictive of response and outcome
Authors: Porrazzo Marika , Baldacci Erminia , Ferretti Antonietta , De Luca Maria Lucia , Barone Francesco , Serrao Alessandra , Aprile Simona Michela , Capria Saveria , Minotti Clara , Martelli Maurizio , Mazzucconi Maria Gabriella , Chistolini Antonio , Santoro Cristina 
Published: August 2021

AbstractBackgroundAcquired Haemophilia A (AHA) patients show a high response rate to immunosuppressive therapy (IST) but few information about predictors of response and outcome are reported.AimsWe describe a large single‐centre AHA cohort, investigating prognostic variables for the ‘best response’ (BR), time to BR (TTBR) and overall survival (OS).MethodsA total of 61 patients were included, collecting data from clinical charts.ResultsA progressive increase in diagnoses, from 1978 to 2019, was observed. Fifty/56 patients (89%) underwent haemostatic therapy (rFVIIa 46%, aPCC 34%) with no significant differences in the response (rFVIIa 92.3% vs aPCC 100%) and no thromboembolic events. Sixty/61 patients underwent first‐line IST with an initial response rate of 58.4%. The 12‐months OS was 85%, the bleeding associated mortality rate 3% (2/61). The response rates at last observation were: CR 64%, PR 8%. We evaluated the influence of age, gender, associated conditions, IST, haemoglobin levels, FVIII:C, inhibitor titre on BR, TTBR and OS: post‐partum AHA achieved the BR after a longer time than AHA related to other aetiologies or idiopathic (p = .05); in univariate analysis female sex (p = .03) and the achievement of BR (p = .001) had a positive impact on the OS while AHA secondary to neoplasms showed a shorter survival (p = .04); only the BR achievement remained significant in multivariate analysis (p = .02).ConclusionsOur data on response and survival confirmed those from the main registries. Post‐partum AHA and BR achievement were significantly associated to a longer TTBR and a longer OS, respectively. Other predictors of outcome deserve to be explored in prospective studies.
Investigation of a sintering phenomenon through master sintering curve based on python software
Authors: Orlandini Mayara Eid , de Araújo Huyra Estevão 
Published: August 2021

AbstractA software for the Master Sintering Curve (MSC) approach has been developed using Python language. An interface with simple steps allows the user to insert data from shrinkage results followed for conversion to densification view and built curves based on MSC theory. The simple software language allows easy adaptation to external users and their specific issues, aiming to improve the sintering phenomena investigation. Finally, three ceramic materials have been analyzed, demonstrating the software operation.
Central blood pressure lowering effect of telmisartan‐rosuvastatin single‐pill combination in hypertensive patients combined with dyslipidemia: A pilot study
Authors: Choi JungMin , Sung Ki‐Chul , Ihm Sang‐Hyun , Yoon Chang‐Hwan , Park Seung Woo , Park Sung‐Ha , Kim Jang‐Young , Kwon Sung‐Uk , Lee Hae‐Young 
Published: August 2021

AbstractThis multicenter, phase 4, Prospective Randomized Open, Blinded End‐point (PROBE) study aimed to evaluate safety and efficacy of telmisartan/rosuvastatin single‐pill combination (SPC) therapy on lowering central blood pressure (BP) compared with telmisartan monotherapy in hypertensive patients with dyslipidemia in Korea. Study was terminated earlier than planned due to COVID‐19 pandemic, thus should be considered as a pilot study. Among 125 patients who met the inclusion criteria of hypertension and dyslipidemia (defined as 10‐year Atherosclerotic Cardiovascular Disease risk score over 5%), 80 patients went through 4‐week single‐group run‐in period with telmisartan 40–80 mg, then randomized to telmisartan 80 mg + rosuvastatin (10 or 20 mg) SPC group or telmisartan 80 mg monotherapy group. The central/brachial BP, brachial‐ankle pulse wave velocity (baPWV), and augmentation index (AIx) were assessed at baseline and 16 weeks later. Mean brachial SBP changed from 135.80 ± 14.22 mmHg to 130.69 ± 13.23 mmHg in telmisartan/rosuvastatin group and from 134.37 ± 12.50 mmHg to 133.75 ± 12.30 mmHg in telmisartan monotherapy group without significant difference (between‐group difference p = .149). Mean central SBP were reduced significantly in the telmisartan/rosuvastatin group with change from 126.72 ± 14.44 mmHg to 121.56 ± 14.56 mmHg while telmisartan monotherapy group showed no significant change (between‐group difference p = .028). BaPWV changed from 1672.57 ± 371.72 m/s to 1591.75 ± 272.16 m/s in telmisartan/rosuvastatin group and from 1542.85 ± 263.70 m/s to 1586.12 ± 297.45 m/s in telmisartan group with no significance (between‐group difference p = .078). Change of AIx had no significant difference (between‐group difference p = .314). Both groups showed excellent compliance rate of 96.9 ± 4.5% with no significant difference in adverse rate. Telmisartan/rosuvastatin SPC therapy was more effective in lowering central BP compared with the telmisartan monotherapy. The results of this study showed benefit of additive statin therapy in hypertensive patients combined with dyslipidemia.
Dehydrozingerone inhibits renal lipotoxicity in high‐fat diet–induced obese mice
Authors: Lee Eun Soo , Kang Jeong Suk , Kim Hong Min , Kim Su Jin , Kim Nami , Lee Jung Ok , Kim Hyeon Soo , Lee Eun Young , Chung Choon Hee 
Published: August 2021

AbstractEctopic fat accumulation in the kidneys causes oxidative stress, inflammation and cell death. Dehydrozingerone (DHZ) is a curcumin analog that exhibits antitumour, antioxidant and antidiabetic effects. However, the efficacy of DHZ in diabetic nephropathy (DN) is unknown. Here, we verified the efficacy of DHZ on DN. We divided the experimental animals into three groups: regular diet, 60% high‐fat diet (HFD) and HFD with DHZ for 12 weeks. We analysed levels of renal triglycerides and urinary albumin and albumin‐creatinine ratio, renal morphological changes and molecular changes via real‐time polymerase chain reaction and immunoblotting. Furthermore, high glucose (HG)‐ or palmitate (PA)‐stimulated mouse mesangial cells or mouse podocytes were treated with DHZ for 24 h. As a result, DHZ markedly reduced renal glycerol accumulation and albuminuria excretion through improvement of thickened glomerular basement membrane, podocyte loss and slit diaphragm reduction. In the renal cortex in the HFD group, phospho‐AMPK and nephrin expression reduced, whereas arginase 2 and CD68 expression increased; however, these changes were recovered after DHZ administration. Increased reactive oxygen species (ROS) stimulated by HG or PA in podocytes was inhibited by DHZ treatment. Collectively, these findings indicate that DHZ ameliorates DN via inhibits of lipotoxicity‐induced inflammation and ROS formation.
Versatile effectors of phytopathogenic fungi target host immunity
Authors: Tariqjaveed Muhammad , Mateen Abdul , Wang Shanzhi , Qiu Shanshan , Zheng Xinhang , Zhang Jie , Bhadauria Vijai , Sun Wenxian 
Published: August 2021

AbstractPhytopathogenic fungi secrete a large arsenal of effector molecules, including proteinaceous effectors, small RNAs, phytohormones and derivatives thereof. The pathogenicity of fungal pathogens is primarily determined by these effectors that are secreted into host cells to undermine innate immunity, as well as to facilitate the acquisition of nutrients for their in planta growth and proliferation. After conventional and non‐conventional secretion, fungal effectors are translocated into different subcellular compartments of the host cells to interfere with various biological processes. In extracellular spaces, apoplastic effectors cope with physical and chemical barriers to break the first line of plant defenses. Intracellular effectors target essential immune components on the plasma membrane, in the cytosol, including cytosolic organelles, and in the nucleus to suppress host immunity and reprogram host physiology, favoring pathogen colonization. In this review, we comprehensively summarize the recent advances in fungal effector biology, with a focus on the versatile virulence functions of fungal effectors in promoting pathogen infection and colonization. A perspective of future research on fungal effector biology is also discussed.
Successful surgical management of massive ovarian teratoma in a rhesus macaque (Macaca mulatta)
Authors: Sangwan Vandana , Anand Arun , Kumar Ashwani , Gupta Kuldip , Mahajan Shashi Kant 
Published: August 2021

AbstractA 5 years‐old Rhesus macaque was presented with abdominal enlargement. The clinical, radiographic and ultrasonographic findings suggested that a massive mass occupying the whole of the abdomen. The mass was surgically removed, and histopathology confirmed ovarian teratoma. The macaque recovered uneventfully; however, the management to avoid self‐mutilation of skin sutures was challenging.
Congenital toxoplasmosis after adalimumab treatment before pregnancy
Authors: Krull Eloïse , Taraschi Gianmarco , El Amari Emmanuelle Boffi , Pellegrinelli Jean‐Marie , Martinez de Tejada Begoña 
Published: August 2021

AbstractWe present a case of congenital toxoplasmosis (TXP) in a woman with Toxoplasma gondii infection more than 6 months before conception. The woman has been treated with adalimumab for ankylosing spondylitis for 4 years until 5 months before conception. TXP serology at the first trimester was compatible with infection prior pregnancy. An ultrasound performed at 26 weeks gestation (WG) showed cerebral echogenic lesions compatible with intrauterine infection. Amniocentesis was performed which confirmed TXP fetal infection. Termination of the pregnancy was performed upon parent's requests and the fetal autopsy confirmed the diagnosis. Here, we discuss the potential role of immunosuppressive treatments, such as adalimumab, in the risk of congenital toxoplasmosis and the importance of counseling before pregnancy.
Detection of pathogens in blood or feces of adult horses with enteric disease and association with outcome of colitis
Authors: Kopper Jamie J. , Willette Jaclyn A. , Kogan Clark J. , Seguin Alexis , Bolin Steven R. , Schott Harold C. 
Published: August 2021

AbstractBackgroundRates of detecting ≥1 potential enteric pathogens (PEP) or toxins (PEP‐T) in feces, blood, or both of horses ≥6 months of age with enteric disease and impact of multiple detections on outcome of horses with colitis has not been reported.ObjectiveTo determine detection rates of PEP/PEP‐T in feces, blood, or both of horses with enteric disease and effect of detecting multiple agents on outcome of horses with colitis.AnimalsThirty‐seven hundred fifty‐three fecal samples submitted to IDEXX Laboratories and 239 fecal and blood samples submitted to Michigan State University's Veterinary Diagnostic Laboratory (MSUVDL).MethodsRetrospective evaluation of PEP/PEP‐T testing results was performed to determine rates of detection of 1 or more PEP/PEP‐T. Impact of detecting multiple agents on outcome was assessed in 239 horses hospitalized for colitis.ResultsOne or more PEP/PEP‐T was detected in 1175/3753 (31.3%) and 145/239 (60.7%) of samples submitted to IDEXX Laboratories and MSUVDL, respectively. In a hospitalized cohort, survival to discharge was lower (76%) in horses with 1 agent, compared to horses with either no (88%) or multiple (89%) agents. There was no difference (P = .78) in days of hospitalization between horses with 0 (1–17), 1 (1–33), and > 1 positive (1–20) result. There was no difference in cost of hospitalization (P = .25) between horses with 0 ($2357, $1110‐15 553), 1 ($2742, $788‐11 005), and >1 positive ($2560, $1091‐10 895) result.Conclusions and Clinical ImportanceDetection rates of PEP/PEP‐T in horses with colitis vary with cohorts and tests performed. Detection of more than 1 PEP or PEP‐T did not affect outcome.
Reliability of monitoring acid‐base and electrolyte parameters through circuit lines during regional citrate anticoagulation‐continuous renal replacement therapy
Authors: Wang Fang , Dai Mingjin , Zhao Yuliang , Yang Yingying , Chen Zhiwen , Lin Li , Tang Xue , Zhang Ling 
Published: August 2021

AbstractBackgroundThe current practice involves blood sampling from the circuit line to measure acid‐base and electrolyte parameters during continuous renal replacement therapy (CRRT). However, there is limited evidence supporting its reliability due to the effects of anticoagulant mechanism and access recirculation associated with regional citrate anticoagulation (RCA).AimTo evaluate the reliability of monitoring acid‐base and electrolyte parameters through circuit lines in regular and reversed connections during RCA‐CRRT.Study designIn this prospective cohort study, we included critically ill patients receiving RCA‐CRRT via a double‐lumen catheter. During the second hour after CRRT initiation, we collected blood samples to monitor acid‐base and electrolyte parameters and their levels were compared between samples from the circuit lines (at 0, 3, and 5 minutes) and those from the central venous catheter (CVC) line (at 0 minute). During this time, CRRT switched to the replacement state as controls.ResultsWe observed 128 CRRT circuits in 60 adult patients receiving RCA‐CRRT. Ninety‐eight (76.6%) circuits had regular connections, while 30 (23.4%) had reversed connections. Among regular connections, no differences were observed in any acid‐base or electrolyte parameters between samples from the CVC line and those from the circuit line at all time points (P > .05). Among reversed connections, ionized calcium levels were dramatically decreased at all three time points in samples from the circuit line compared with those from the CVC line (0.65 ± 0.12, 0.72 ± 0.11, and 0.78 ± 0.99 vs 0.98 ± 0.07 mmol/L, P < .001), with comparable levels of other acid‐base or electrolyte parameters between the sampling patterns (P > .05).ConclusionsAcid‐base and electrolyte parameters could be reliably monitored through the circuit line during RCA‐CRRT in regular connections. However, in reversed connections, pre‐filter ionized calcium concentrations determined through the circuit line were lower than those determined through the CVC line.Relevance to clinical practiceWe suggest sampling from arterial or CVC lines rather than from the circuit line in a reversed connection during RCA‐CRRT.
Association between the posterior ocular contour pattern and progression of myopia in children: A prospective study based on OCT imaging
Authors: Xu Shengsong , Hu Yin , Cui Dongmei , Zhao Feng , Jiang Jinyun , Feng Zhibin , Li Cong , Li Zhouyue , Yang Xiao 
Published: August 2021

AbstractPurposeThis study aims to reveal the relationship between the posterior ocular contour and the subsequent progression of myopia in children.MethodsChildren aged 8–12 years with myopia received baseline measurements and were instructed to wear their glasses every day and return for a follow‐up visit after one year. Axial length and other ocular parameters were measured using a noncontact biometer. The contour of the posterior eye was calculated and analysed based on images from spectral domain optical coherence tomography (SD‐OCT). Univariate and multivariate linear regression models were created to analyse the relationship between the contour of the posterior eye and the progression of myopia.ResultsBaseline posterior ocular contour measurements correlated with baseline axial length and spherical equivalent refraction (SER) (all p < 0.05). Eyes that were more myopic tended to have a more prolate posterior ocular contour. Although the baseline contour of the retinal pigment epithelium (RPE) and chorioscleral interface (CSI) showed no significant relationship with the progression of myopia (all p > 0.05), interestingly, when the baseline contour of the RPE was more prolate than that of the CSI, the axial length increased during the following year (R2 = 0.62; p < 0.01). The multivariate model, when adjusted for other variables, further validated the independent role of this variable.ConclusionsThe difference between the RPE and CSI contours correlated with the subsequent progression of myopia in children. This finding can help inform clinicians regarding the management of children at the onset of myopia and potentially provide an avenue for experimental research on the mechanism of myopia development.
Clinical factors affecting pupillary light reflex parameters: a single‐centre, cross‐sectional study
Authors: Ishikawa Masaaki 
Published: August 2021

AbstractPurposeTo evaluate the effects of stimulus intensity, aging, sex, smoking and eye symmetry on pupillary light reflex (PLR) parameters.MethodsWe evaluated 2812 eyes from 1406 subjects in a single‐centre, cross‐sectional study. PLR data were collected using four different stimulus intensities. We prepared two models for each of the eight PLR parameters, and defined the model with the lowest values of Akaike's information criterion (AIC) as being the best‐fit. Model A was a linear regression model without adjustment for among‐individual variability, while the Model B linear mixed‐effects models (LMMs) were adjusted for among‐individual variability. The regression coefficients of the two models were compared.ResultsModel B showed the lowest AIC values for all parameters and the best fit. For light stimulus intensity, age and eye symmetry, the two models yielded similar results for all PLR parameters. For sex and smoking index, some PLR parameters showed the opposite results, i.e., Model A showed significant effects while Model B did not.ConclusionThese results indicate that light stimulus intensity, aging, sex, smoking and eye symmetry are factors that affect PLR parameters. These should be adjusted when evaluating the clinical potential of PLR as a diagnostic tool. In addition, adjusting for among‐individual variability due to LMMs can improve the model fit and reduce false positives. This can reveal the association between clinical factors and PLR parameters with increased accuracy.
A New Approach to the Gender Pay Gap Decomposition by Economic Activity
Authors: Lombardía María José , López-Vizcaíno Esther , Rueda Cristina 
Published: August 2021

Abstract
The aim of this paper is to present an original approach to estimate the gender pay gap (GPG). We propose a model-based decomposition, similar to the most popular approaches, where the first component measures differences in group characteristics and the second component measures the unexplained effect; the latter being the real gap. The novel approach incorporates model selection and bias correction. The pay gap problem in a small area context is considered in this paper, although the approach is flexible to be applied to other contexts. Specifically, the methodology is validated for analysing wage differentials by economic activities in the region of Galicia (Spain) and by analysing simulated data from an experimental design that imitates the generation of real data. The good performance of the proposed estimators is shown in both cases, specifically when compared with those obtained from the widely used Oaxaca–Blinder approach.
Biomineralization processes in modern calcareous tufa: Possible roles of viruses, vesicles and extracellular polymeric substances (Corvino Valley – Southern Italy)
Authors: Perri Edoardo , Słowakiewicz Mirosław , Perrotta Ida D. , Tucker Maurice E. 
Published: August 2021

AbstractA modern lithifying biofilm, associated with fluvial calcareous tufa in southern Italy, is composed of a complex community of micro‐organisms including autotrophic and heterotrophic bacteria, together with likely viruses (bacteriophages) and bacterial vesicles. Produced by most of the bacterial forms, extracellular polymeric substances are widespread and are the main sites of mineral precipitation, rather than the microbial cells themselves, but viruses and vesicles also appear to be mineralized. Neoformed biominerals replace these organic substrates starting with an amorphous phase rich in Ca, Si and several other cations followed by two different types of proto‐crystal: a granular−irregular Ca‐rich type and a lamellar/fibrous Si‐Al‐Mg‐rich type. Their growth leads to the formation of Ca‐carbonate and Mg‐silicate crystals that preserve their initial different habits. The coeval precipitation of silicate and carbonate at the initial stage of bio‐mediated mineral formation is a process common within freshwater and saline to hypersaline‐water calcareous microbialites. This is most probably related to the initial formation of poorly‐crystallized Mg‐Si phases that precipitate within the extracellular polymeric substances, related to the rise of pH in the zone of active oxygenic photosynthesis, and the mineralization of viruses, associated with the successive nucleation of Ca‐carbonate in close proximity to bacterial degradation of organic matter.
Death, Politics, and Heidegger’s Bremen Remarks
Authors: O’Brien Mahon 
Published: August 2021

AbstractThe controversy surrounding Heidegger’s remarks on the Holocaust in Bremen in 1949 erupted again recently, owing to some of the revelations concerning Heidegger’s antisemitism in recently published notebooks from the 1930s in particular. An overlooked dimension to this controversy within a controversy is the specific relationship between Heidegger’s account of being‐towards‐death in Being and Time and his remarks in Bremen in 1949. One of the most notorious passages from the Bremen lectures is best understood against the backdrop of Heidegger’s account of death in Being and Time where he distinguishes between the notions of death (as a way for Dasein to be) and perishing. In this article, we will revisit Heidegger’s account of being‐towards‐death and the concomitant notion of Dasein (as the way of being for the human being) before looking at the conflicting ways that he will invoke those ideas in subsequent work. We will further challenge the criticisms of Heidegger’s Bremen remarks in some recent literature and offer a competing interpretation.