bluuebunny/crossref_metadata_2025_split huggingface dataset:
KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases
Authors: Huang Liang-Chin , Taujale Rahil , Gravel Nathan , Venkat Aarya , Yeung Wayland , Byrne Dominic P , Eyers Patrick A , Kannan Natarajan 
Published: March 2021

AbstractProtein kinases are among the largest druggable family of signaling proteins, involved in various human diseases, including cancers and neurodegenerative disorders. Despite their clinical relevance, nearly 30% of the 545 human protein kinases remain highly understudied. Comparative genomics is a powerful approach for predicting and investigating the functions of understudied kinases. However, an incomplete knowledge of kinase orthologs across fully sequenced kinomes severely limits the application of comparative approaches for illuminating understudied kinases. Here, we propose KinOrtho, a query- and graph-based orthology inference method that combines full-length and domain-based approaches to map one-to-one kinase orthologs across 17 thousand species. Using multiple metrics, we show that KinOrtho performed better than existing methods in identifying kinase orthologs across evolutionarily divergent species and eliminated potential false positives by flagging sequences without a proper kinase domain for further evaluation. We demonstrate the advantage of using domain-based approaches for identifying domain fusion events, highlighting a case between an understudied serine/threonine kinase TAOK1 and a metabolic kinase PIK3C2A with high co-expression in human cells. We also identify evolutionary fission events involving the understudied OBSCN kinase domains, further highlighting the value of domain-based orthology inference approaches. Using KinOrtho-defined orthologs, Gene Ontology annotations, and machine learning, we propose putative biological functions of several understudied kinases, including the role of TP53RK in cell cycle checkpoint(s), the involvement of TSSK3 and TSSK6 in acrosomal vesicle localization, and potential functions for the ULK4 pseudokinase in neuronal development.The well-curated kinome ortholog set can serve as a valuable resource for illuminating understudied kinases, and the KinOrtho framework can be extended to any gene-family of interest.
Can continuous learning amplify employees' change-efficacy and contextual performance? Evidence from post-merger Indian organization
Authors: Budhiraja Sunil 
Published: March 2021

PurposeContinuous learning has been referred to as an integral phenomenon of learning organization. While a range of studies have associated continuous learning with employee performance; understanding of this relationship remains underdeveloped in the context of mergers and acquisitions. The present study investigates the relationship among continuous learning, change-efficacy and contextual performance of employees working with a recently merged bank and further explores the mediating role of employees' change-efficacy in relationship between continuous learning and contextual performance of employees.Design/methodology/approachA research model with underlying hypothesis is proposed by drawing upon the theory of transformative learning, social cognitive theory and theory of change management. Cross-sectional data was collected from bank employees undergoing integration in a post-merger phase.FindingsThe findings of the study suggest that continuous learning influences employees' change-efficacy and change-efficacy significantly mediates the relationship between continuous learning and contextual performance of employees. The empirical association drawn from the variables has been recognized by extant research as a brighter manifestation of learning organizations.Research limitations/implicationsThe research is undertaken in a large Indian bank and the analysis is based on cross-sectional data which may not be generalized across a broader range of sectors and international environment.Practical implicationsThe findings of the study have a potential to help HR practitioners to utilize continuous learning in change management by enhancing contextual performance of employees post-mergers and acquisitions.Originality/valueThe study is one of its kinds in a post-merger setup which captures the outcomes of continuous learning by either confirming or extending the existing theories.
A protocol for the management of hyponatremia peri‐liver transplant reduces post‐transplant neurological complications
Authors: Crismale James F. , Huisman Tsipora , Deshpande Richa , Law Cindy , Im Gene Y. , Bronster David , DeMaria Samuel , Florman Sander , Schiano Thomas D. 
Published: March 2021

AbstractRapid changes in serum sodium (ΔSNa) peri‐liver transplant (LT) predispose to post‐LT neurological complications (NC). We aimed to assess whether implementation of a protocol directed at limiting peri‐LT ΔSNa reduced post‐LT NC. A retrospective single‐center review of adult LT recipients from 1/2016 to 10/2017 was performed. Patients with hyponatremia (SNa < 135 mEq/L) within 7 days of LT were analyzed in two eras: pre‐protocol (1/2016‐9/2016) and post‐protocol (10/2016‐10/2017). The primary outcome was the development of NC within 1 month of LT. Perioperative ΔSNa (ΔSNaPost‐LT) was assessed as a secondary outcome. Among 85 and 107 patients who underwent LT pre‐ and post‐protocol, 39 (46%) and 42 (39%) were hyponatremic within 7 days of LT, respectively. Significantly fewer patients in the post‐protocol era developed NC vs. pre‐protocol (7.1% vs. 25.6%, p = .02). Additionally, fewer LT recipients in the post‐protocol era developed ΔSNaPost‐LT ≥ 10 mEq/L (9.5% vs. 30.7%, p = .02). Intraoperatively, more patients post‐protocol received hypotonic saline (33.3% vs. 2.6%, p < .01). Multivariable logistic regression revealed that transplantation in the post‐protocol era was associated with significantly reduced odds (odds ratio 0.11, 95% confidence interval 0.01–0.50) of developing NC. In conclusion, the implementation of a multidisciplinary protocol aimed at reducing ΔSNa peri‐LT was independently associated with a reduction in post‐LT NC.
The usefulness of echocardiography in the diagnosis of myocarditis in a young man after sudden cardiac arrest
Authors: Sacharczuk Wioletta , Dankowski Rafał , Szyszka Andrzej 
Published: March 2021

AbstractThe diagnosis of acute myocarditis (AM) remains challenging because of its diverse clinical manifestations. Thus, a wide range of diagnostic tests may be warranted. Although cardiac magnetic resonance (CMR) is the preferred imaging technique, it may not be applicable in the acute AM phase. Our case report highlights the usefulness and diagnostic accuracy of echocardiographic examination. In the first 2‐dimensional echocardiography, the focal echobright was presented. A reduced value of global longitudinal strain and regional disturbances of segmental myocardial strain, both longitudinal and circumferential, in the epicardial layer, were detected with a good correlation with CMR results.
Indocyanine green guidance improves the efficiency of extended pelvic lymph node dissection during laparoscopic radical prostatectomy
Authors: Claps Francesco , Ramírez‐Backhaus Miguel , Mir Maresma Maria Carmen , Gómez‐Ferrer Álvaro , Mascarós Juan Manuel , Marenco Josè , Collado Serra Argimiro , Casanova Ramón‐Borja Juan , Calatrava Fons Ana , Trombetta Carlo , Rubio‐Briones Jose 
Published: March 2021

ObjectivesTo evaluate whether indocyanine green guidance can improve the quality of extended pelvic lymph node dissection in patients undergoing radical prostatectomy.MethodsA total of 214 patients underwent laparoscopic radical prostatectomy with indocyanine green‐guided lymph node dissection plus extended pelvic lymph node dissection. These patients (group A) were matched 1:1 for clinical risk groups according to the National Comprehensive Cancer Network classification with patients who underwent the same procedure without fluorescence guidance (group B). Biochemical recurrence was defined as two consecutive prostate‐specific antigen rises of at least 0.2 ng/mL. The Kaplan–Meier method and Cox regression models were used to identify predictors of biochemical recurrence.ResultsThe median number of retrieved nodes was significantly higher in group A (22 vs 14, P < 0.001). The rate of lymph node metastases was higher in group A (65.9% vs 34.1%, P = 0.01). Increasing the yield of lymph node dissection was independently and negatively correlated with the biochemical recurrence risk in both overall and pN‐positive patients (hazard ratio 0.97, P = 0.03; and hazard ratio 0.95, P = 0.02). The 5‐year biochemical recurrence‐free survival rates were (75.8% vs 65.9, P = 0.09) and (54.1% vs 24.9%, P = 0.023) for group A and group B in the overall cohort and pN‐positive cohort, respectively.ConclusionIndocyanine green‐guided lymph node dissection plus extended pelvic lymph node dissection improves identification of lymphatic drainage, resulting in a higher number of lymph nodes and retrieved lymph node metastases, and allowing a more accurate local staging and a prolonged biochemical recurrence‐free survival.
Non‐interventional weight changes affect systolic blood pressure in normotensive individuals
Authors: Shlomai Gadi , Ovdat Tal , Klempfner Robert , Leibowitz Avshalom , Grossman Ehud 
Published: March 2021

AbstractThe association between obesity and hypertension is well established. Weight loss has been shown to reduce blood pressure (BP) among hypertensive patients. Nevertheless, the effect of weight changes on BP in normotensive individuals is less clear. The author explored the association between non‐interventional weight alterations and BP changes in a large cohort of normotensive adults. This is a retrospective analysis of normotensive individuals, between 2010 and 2018. All weight changes were non‐interventional. Body mass index (BMI) and BP were measured annually. Patients were divided according to the change in BMI between visits: reduction of more than 5% ("large reduction"), between 2.5% and 5% ("moderate reduction"), reduction of <2.5% or elevation of <2.5% ("unchanged"), elevation between 2.5% and 5% ("moderate increase"), and elevation of more than 5% ("large increase"). The primary outcome was the change in systolic BP (SBP) between the visits. The final analysis included 8723 individuals. 20% of the patients reduced their BMI by at least 2.5% and 24.5% increased their BMI by more than 2.5%. "High reduction" inferred an absolute decrease of 3.6 mmHg in SBP, while "large increase" resulted in an absolute increase of 1.9 mmHg in SBP. The proportion of individuals with at least 10 mmHg decrease in SBP progressively declined according to the relative decrease in BMI, and the proportion of patients with at least 10 mmHg increase in SBP progressively increased. This effect was more pronounced in individuals with higher baseline SBP. Among normotensive adults, modest non‐interventional weight changes may have significant effects on SBP.
On the link of self‐esteem, life satisfaction, and Neuroticism
Authors: Hufer‐Thamm Anke , Riemann Rainer 
Published: March 2021

AbstractObjectiveSelf‐esteem (SE) and life satisfaction (LS) are highly correlated but little is known about the sources of this association. Both characteristic adaptations are negatively correlated with Neuroticism (N). We investigated the relationship between SE, LS, and N and the degree to which shared variance was explained by N from a behavior genetic perspective.MethodWe analyzed more than 2,000 German same‐sex twin pairs and their siblings. Twins were 17 and 23 years old and siblings were M = 21.6 years old. The sample was balanced regarding gender. We applied multivariate twin‐sibling Cholesky models to obtain genetic and environmental correlations and estimated the impact N had on genetic and environmental correlations of SE and LS.ResultsThe genetic correlation between SE and LS was .99 and 47% of this phenotypic correlation was explained by genetics. About 28% of the common genetic variance between SE and LS was explained by shared genes with N.ConclusionsOur findings suggest that N is not a common factor of SE and LS. The results are not in line with theories assuming that N is a basic tendency whose genetic factors account for most of the genetic variance between the assumed characteristic adaptations SE and LS.
Integration of the optimized descriptive profile and temporal dominance of sensations methodologies
Authors: Crepalde Ludmylla Tamara , Vidigal Márcia Cristina Teixeira Ribeiro , Carneiro João de Deus Souza , Minim Valéria Paula Rodrigues 
Published: March 2021

AbstractThe multi‐attribute temporal analysis temporal dominance of sensations (TDS) allows for obtaining a qualitative explanation of the interaction and order of perception of the sensory attributes of a product. Considering the need for quantitative complementation of TDS data and a shorter analysis time to obtain a more complete sensory profile, it was proposed that the evaluators who performed the optimized descriptive profile (ODP) also evaluate the samples using the TDS, seeking to integrate the two sensory methodologies. For this, the sensory profile of five grape beverages with different sucrose concentrations and dilution factors was evaluated using the ODP and TDS methodologies. Integration of the ODP and TDS methodologies proved to be adequate, by optimizing the time required for obtaining the complete quantitative profile of the beverages, complemented by the order of perception of the attributes during the evaluation. This allowed for a more comprehensive analysis of the food matrix sensory profile.Practical applicationsThe association between the methodologies temporal dominance of sensations (TDS) and optimized descriptive profile (ODP) permitted the identification of a sensory profile via different approaches, providing better interpretations of the evaluations. The differences between the intensity of attributes in a traditional descriptive analysis (punctual) and dominance perceptions in a temporal analysis, is justified when observed that the most intense attributes are not always those that dominate on the palate while food is ingested (taste over time). Acquisition of the more ample sensory profile (ODP + TDS) allows for better understanding the attributes identified by the panelists. Therefore, when using this sensory analysis industries may be able to reformulate and improve their products, monitoring the interaction of ingredients with evaluator's perceptions.
Pre‐procedural arrhythmia burden and the outcome of catheter ablation of idiopathic premature ventricular complexes
Authors: Asatryan Babken , Seiler Jens , Bourquin Luc , Knecht Sven , Servatius Helge , Madaffari Antonio , Baldinger Samuel H. , Badertscher Patrick , Küffer Thomas , Spies Florian , Tanner Hildegard , Kühne Michael , Osswald Stefan , Roten Laurent , Sticherling Christian , Reichlin Tobias 
Published: March 2021

AbstractBackgroundRadiofrequency catheter ablation of idiopathic premature ventricular complexes (PVCs) is an effective method for eliminating symptoms and preventing/reversing arrhythmia‐induced cardiomyopathy. One reason for procedural failure is low PVC frequency during the procedure. We aimed to investigate the relation between pre‐procedural PVC burden and outcome of idiopathic PVC catheter ablation.MethodsPatients who underwent idiopathic PVC ablation between 2013 and 2019 at two tertiary referral centers were retrospectively included. All procedures were performed using irrigated‐tip ablation catheters and a 3D electro‐anatomical mapping system. Sustained ablation success was defined as a ≥80% reduction of pre‐procedural PVC burden determined by 24h‐Holter at follow‐up.ResultsOverall, 254 patients (median age 54 years [IQR 42–64]; 47% male) were enrolled. The median pre‐ablation PVC‐burden was 22% (IQR 11–31%), which was reduced to a post‐ablation PVC burden of 0.3% (IQR 0–4%) after a median of 90 days. Sustained ablation success was achieved in 182 patients (72%). Pre‐procedural PVC burden did not differ between patients with sustained ablation success and recurrence during follow‐up (median 21% vs. 22%, p = .76). When assessed in pre‐ablation PVC‐burden groups of ≤5%, 6–15%, 16–30%, and ≥31%, sustained ablation success was achieved in 67%, 75%, 71%, and 72%, respectively, with no significant difference (p = .89). Sustained ablation outcome for PVC‐burden ≤5% versus >5% showed no difference either (67% vs. 72%, p = .52).ConclusionsPre‐procedural Holter‐determined PVC burden does not predict the outcome of idiopathic PVC ablation. Thus, catheter ablation may be a reasonable first choice also for patients with symptomatic yet rare PVCs.
Cyprinid herpesvirus‐2 (CyHV‐2): a comprehensive review
Authors: Thangaraj Raja Swaminathan , Nithianantham Sundar Raj , Dharmaratnam Arathi , Kumar Raj , Pradhan Pravata Kumar , Thangalazhy Gopakumar Sumithra , Sood Neeraj 
Published: March 2021

AbstractCyprinid herpesvirus‐2 (CyHV‐2) is a linear double‐stranded DNA virus in the genus Cyprinivirus of family Alloherpesviridae. The virus is known to be highly pathogenic to ornamental goldfish (Carassius auratus), crucian carp (C. carassius) and Gibel carp (C. auratus gibelio), and also to the hybrids of goldfish and other carps. Cyprinid herpesvirus‐2, having the smallest genome (290.3 kb) among Cyprinivirus, causes herpesviral hematopoietic necrosis disease (HVHND) that results in huge economic losses in aquaculture industry as the disease can cause high mortality (50–100%) among the affected fish. The disease was initially reported as the cause of epizootics in juvenile goldfish of Japan during 1992 and 1993. To date, this disease has been reported around the world including Europe, North America, Oceania and Asia. Huge economic losses due to the CyHV‐2 infection among cultured gibel carp in China, during 2011–2012, mass mortality in crucian carp during 2012 in Italy, 95% mortality in goldfish during 2014 in France, 85% mortality in goldfish during 2016 in Poland had been reported. Strategies for controlling the spread of CyHV‐2 are thus urgently required to limit economic damage. Furthermore, the review will shed light on lacunae in current knowledge as well as on the perspectives that merits further investigations on CyHV‐2 research. The paper forms the first comprehensive overview of CyHV‐2 causing a serious economically significant fish disease and, will be helpful for the researchers to get all related information from a single manuscript.
Bare‐difference methodology and the scientific analogy
Authors: Kopeikin Zak A. 
Published: March 2021

AbstractThe bare‐difference methodology is considered to be a powerful tool in ethical reasoning. The underlying idea is that we can identify the intrinsic evaluative significance of some feature by constructing contrast cases or bare‐difference cases, i.e., two cases that hold everything constant but for the feature of interest. While this popular methodology has been challenged by prominent philosophers such as Kagan, Thomson, and Kamm, it is intuitively appealing because, as Perrett identifies, the methodology appears to share the same logical structure as a fruitful scientific procedure. In this paper, I argue that examining this ‘scientific analogy’ is crucial to understanding both the limitations and the prospects for ethical bare‐difference reasoning. I expand upon Perrett's discussion of the scientific analogy and examine another relevant similarity. I then highlight two relevant dissimilarities between ethical bare‐difference reasoning and its scientific analogue. Though these differences threaten to undermine the analogy, I show how the analogy might be mended to better bring the ethical methodology in line with its scientific counterpart and avoid challenges to ethical bare‐difference methodology raised by philosophers in the literature.
An MRI approach to assess placental function in healthy humans and sheep
Authors: Saini Brahmdeep S. , Darby Jack R. T. , Marini Davide , Portnoy Sharon , Lock Mitchell C. , Yin Soo Jia , Holman Stacey L. , Perumal Sunthara R. , Wald Rachel M. , Windrim Rory , Macgowan Christopher K. , Kingdom John C. , Morrison Janna L. , Seed Mike 
Published: March 2021

Key points
Human placental function is evaluated using non‐invasive Doppler ultrasound of umbilical and uterine artery pulsatility indices as measures of resistance in placental vascular beds, while measurement of placental oxygen consumption () is only possible during Caesarean delivery.
This study shows the feasibility of using magnetic resonance imaging (MRI) in utero to measure blood flow and oxygen content in uterine and umbilical vessels to calculate oxygen delivery to and by the gravid uterus, uteroplacenta and fetus.
Normal late gestational human uteroplacental by MRI was ∼4 ml min−1 kg−1 fetal weight, which was similar to our MRI measurements in sheep and to those previously measured using invasive techniques.
Our MRI approach can quantify uteroplacental , which involves the quantification of maternal‐ and fetal‐placental blood flows, fetal oxygen delivery and , and the oxygen gradient between uterine‐ and umbilical‐venous blood, providing a comprehensive assessment of placental function with clinical potential.
AbstractIt has not been feasible to perform routine clinical measurement of human placental oxygen consumption () and in vitro studies do not reflect true metabolism in utero. Here we propose an MRI method to non‐invasively quantify in utero placental and fetal oxygen delivery () and in healthy humans and sheep. Women (n = 20) and Merino sheep (n = 10; 23 sets of measurements) with singleton pregnancies underwent an MRI in late gestation (36 ± 2 weeks and 128 ± 9 days, respectively; mean ± SD). Blood flow (phase‐contrast) and oxygen content (T1 and T2 relaxometry) were measured in the major uterine‐ and umbilical‐placental vessels, allowing calculation of uteroplacental and fetal and . Maternal (ml min−1 kg−1 fetus) to the gravid uterus was similar in humans and sheep (human = 54 ± 15, sheep = 53 ± 21, P = 0.854), while fetal (human = 25 ± 4, sheep = 22 ± 5, P = 0.049) was slightly lower in sheep. Uteroplacental and fetal (ml min−1 kg−1 fetus; uteroplacental: human = 4.1 ± 1.5, sheep = 3.5 ± 1.9, P = 0.281; fetus: human = 6.8 ± 1.3, sheep = 7.2 ± 1.7, P = 0.426) were similar between species. Late gestational uteroplacental:fetal ratio did not change with age (human, P = 0.256; sheep, P = 0.121). Human umbilical blood flow (ml min−1 kg−1 fetus) decreased with advancing age (P = 0.008), while fetal was preserved through an increase in oxygen extraction (P = 0.046). By contrast, sheep fetal was preserved through stable umbilical flow (ml min−1 kg−1; P = 0.443) and oxygen extraction (P = 0.582). MRI derived measurements of uteroplacental and fetal between humans and sheep were similar and in keeping with prior data obtained using invasive techniques. Taken together, these data confirm the reliability of our approach, which offers a novel clinical ‘placental function test’.