bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-objective optimization of CCUS supply chains for European countries with higher carbon dioxide emissions
Authors: Leonzio Grazia , Foscolo Pier Ugo , Zondervan Edwin 
Published: May 2021

Abstract
This research work wants to overcome the gap present in the literature, reformulating our single optimization problems of a CCUS supply chain for Germany, Italy and the UK (European countries with higher carbon dioxide emissions) as bi-objective problems. The amount of captured carbon dioxide is maximized while total costs are minimized at the same time. Results show that, for solving this problem, the augmented ε-constraint method is more efficient than the traditional ε-constraint method, and the respective Pareto fronts with environmentally and economically efficient solutions are obtained. These plots are utilized to suggest scenarios for a decision maker, considering only the total costs objective function (the scenario with the minimum value of net total cost is selected) or both objective functions (the scenario with the shortest distance from the Utopia point is chosen). In the second option, the CCUS supply chain of Germany is that closest to the ideal conditions, even if the system has the highest costs.
Chemometric exploratory data analysis for patients with diabetes type 2 and diabetic complications
Authors: Nedyalkova Miroslava , Robeva Ralitsa , Elenkova Atanaska , Simeonov Vasil 
Published: May 2021

Abstract
The present study deals with the interpretation and modeling of clinical data for patients with diabetes mellitus type 2 (DMT2) additionally diagnosed with complications of the disease by the use of multivariate statistical methods. The major goal is to determine some specific clinical descriptors characterizing each health problem by applying the options of the exploratory data analysis. The results from the statistical analysis are commented in details by medical reasons for each of the complications. It was found that each of the complications is characterized by specific medical descriptors linked into each one of the five latent factors identified by factor and principal components analysis. Such an approach to interpret concomitant to DMT2 complications is original and allows a better understanding of the role of clinical parameters for diagnostic and prevention goals.
SCREENING AND ISOLATION OF THERMOPHILIC FUNGI OBTAINED FROM THREE SELECTED COMPOST WASTES SITES
Authors: Ibraheem Omodele , Adetuyi Oluwafijimi , Kalejaiye Sheriff , John Victoria , Fayela Wuraola , Ajayi John M. 
Published: May 2021

Thermostable enzymes have found applications in the improvement of products quality in various industries. Despite the discovery of several microorganisms as potential source of thermostable enzymes, more biodiversity explorations are currently been carried out for high activity enzymes producing isolates. The discovery of new isolates having these characters will allow to efficiently carry out reactions in various industrial processes that involve extreme conditions. This study was aimed to screen and isolate thermophilic fungi from three selected compost wastes sites (Palm oil mill, Wood chip piles and Abattoir dump), and identify potential producers of lipases, cellulases and proteases respectively. The thermophilic fungi were obtained from an equal depth of one meter in all the three collection sites with a temperature range of 40 to 45OC and later cultured at 70 OC. Further experimental screening analysis showed the presences of lipase, cellulase and protease producing fungi present in samples collected from palm oil mill, wood chips pills and abattoir dump site respectively. The isolated fungi were used for enzyme production in submerged fermentation for 10 days at 50OC. Culture filtrate obtained from the medium of production were used for the assessment of enzymatic activity. The highest lipase, cellulase and protease activities were obtained from isolates 3 A (56.56 U/mL), 3A (38.35 U/mL) and 2B (3.0 U/mL) respectively. These isolates with high enzymes activities were identified microscopically as Rhizopus sp., Aspergillus flavus and Neurospora sp. accordingly. We believed that these strains could be further exploited for numerous industrial applications that require thermophilic enzymes.
Expression and polymorphism of lTLR4 receptors in pathogenesis of chronic obstructive pulmonary disease: a modern view
Authors: Beloglazov V. A. , Yatskov I. A. , Useinova Rean Hayrievna 
Published: May 2021

Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by irreversible or partially reversible obstruction of the bronchial tree. Currently, there are many proven links in the COPD etiopathogenesis, among which a pivotal role is assigned to the value of the hyperergic inflammatory reaction in response to inhalation of various harmful substances (tobacco smoke, industrial pollutants, etc.). The number of macrophages, neutrophils, lymphocytes increases in the lungs of COPD patients, and these cells secrete a fairly wide range of inflammatory mediators. Bacterial colonization of the airways is one of the key features in COPD pathogenesis leading to persistent or chronic stimulation of immune cells through Tolllike receptors (TLR), which perceive the pathogen-associated molecular patterns (PAMPs).This article provides a review of literature concerning modern concepts of the role of Toll-like receptors expression and polymorphism, in particular, TLR4, in pathogenesis of COPD. TLR4 is a member of the Tolllike receptor family that plays a fundamental role in pathogen identification and innate immune activation. By recognizing the pathogen-associated molecular patterns (PAMPs) expressed on infectious agents, TLRs mediate the production of cytokines necessary for the development of effective immunity. Different TLRs exhibit distinct expression patterns. This receptor is most abundantly expressed in placenta and in the myelomonocytic leukocyte subpopulations. E.g., Di Stefano A. et al. (2017), determined immunohistochemically the expression levels of TLR2, TLR4, TLR9, NOD1, NOD2, CD14, Toll-interleukin-1-receptor domain containing adapter protein (TIRAP) and interleukin-1-receptor-associated phosphokinases (IRAK1 and IRAK4) in bronchial mucosa of patients with stable COPD of varying severity. It was found that TLR4 expression of the bronchial epithelium positively correlated with degree of obstruction and CD4+ and CD8+T cell contents. Stimulation of TLR4 increases cytokine production, which may be a relevant mechanism by which bacteria cause excessive inflammation in COPD patients. The degree of TLR4 involvement into COPD pathogenesis requires more detailed study in future, in order to determine the main mechanisms for emerging inflammatory response in the airways. This review article is part of a research grant project to study pro-inflammatory response to endotoxin of Gram-negative flora in COPD pathogenesis (State registration number – АААА-А19-119122390040-2).
IgM- and IgA-response of peritoneal B-1 cells to the TI-2 antigen with the presence of γδT cells in vitro
Authors: Snegireva N. A. , Sidorova E. V. , Dyakov I. N. , Gavrilova M. V. , Chernyshova I. N. , Pashkov E. P. , Svitich O. A. 
Published: May 2021

IgA is an important component of the mucosal system of the body. It limits penetration of pathogens into the bloodstream. Inflammatory diseases such as Crohn disease and colitis may be associated with disorders of IgA synthesis. Both B1 and B2 cells are a source of IgA in the intestines. Special attention is paid to B1 cells, which are able to respond to T-independent type 2 antigens and produce natural antibodies. B1 cells produce about 50% of the intestinal IgA including specific antibodies to the components of microorganisms contained in the gastrointestinal tract. The mechanism of IgA formation in the T-independent way is not investigated in details. It was suggested that the γδТ-cells promote switching to IgA synthesis by B1 cells. This assumption may be supported by their co-localization with B1 lymphocytes in the intestinal mucosa, as well as participation, along with B1 cells, in formation of the first-line defense against the pathogens. In addition, the both lymphocyte subpopulations evolve during initial ontogenesis, earlier than “classic” В2 and αβT cells. Therefore, it was suggested that γδT lymphocytes may be involved into the processes of induction and/or regulation of IgM and IgA production by B1 cells in response to TH2 antigens.In the present study, we have shown the effect of γδT cells upon generation of IgM- and IgA-forming B1 cells in response to α-1,3-dextran in vitro. We also studied the dynamics of the mRNA expression for IgM- and IgA-heavy chains by the B1 cells at different terms of in vitro culture.It was found that, during co-cultivation of B1 cells with 20% γδT lymphocytes, there is no increase in the number of dextran-specific IgM-producing cells. The B1 cells exhibited an increase of IgM heavy chain mRNA expression in response to dextran but not in co-cultures. Expression of mRNA for IgM heavy chains in co-cultures was decreased compared to non-treated B-cell cultures. Contrary to the earlier assumption, a presence of γδT lymphocytes in culture did not enhance the formation of IgA producents. The obtained data suggest regulatory properties of the γδТ lymphocytes during the B1 cells response to T-independent antigens.
Plasma cytokines in patients with COVID-19 during acute phase of the disease and following complete recovery
Authors: Arsentieva N. A. , Liubimova N. E. , Batsunov O. K. , Korobova Z. R. , Stanevich O. V. , Lebedeva A. A. , Vorobyov E. A. , Vorobyova S. V. , Kulikov A. N. , Lioznov D. A. , Sharapova M. A. , Pevtcov D. E. , Totolian A. A. 
Published: May 2021

COVID-19, an infection caused by the new coronavirus SARS-CoV-2, is associated with a number of pathophysiological mechanisms, mobilizing a wide spectrum of biomolecules, mainly, cytokines.The purpose of this studywas to evaluate levels of multiple cytokines in blood plasma from the patients with COVID-19 during acute phase of the disease, and upon complete recovery. Samples of peripheral blood plasma of 56 patients with COVID-19, 69 convalescents and 10 healthy individuals were examined. Concentrations of 46 molecules, such as IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-9, IL-12 (p40), IL-12 (p70), IL-13, IL-15, IL-17A/CTLA8, IL-17-E/IL-25, IL-17F, IL-18, IL-22, IL-27, IFNα2, IFNγ, TNFα, TNFβ/ Lymphotoxin-α (LTA), CCL2/MCP-1, CCL3/MIP-1α, CCL4/MIP-1β, CCL7/MCP-3, CCL11/Eotaxin, CCL22/MDC, CXCL1/GROα, CXCL8/IL-8, CXCL9/MIG, CXCL10/IP-10, CX3CL1/Fractalkine, IL-1ra, IL-10, EGF, FGF-2/FGF-basic, Flt3 Ligand, G-CSF, M-CSF, GM-CSF, PDGF-AA, PDGF-AB/ BB, TGF-α, VEGF-A were measured via xMAP multiplexing technology. Significantly increased levels of 18 cytokines were found in blood plasma from COVID-19 patients during acute phase of the disease (as compared to control group), i.e., IL-6, IL-7, IL-15, IL-27, TNFα, TNFβ/Lymphotoxin-α (LTA), CCL2/MCP-1, CCL7/MCP-3, CXCL1/GROα, CXCL8/IL-8, CXCL10/IP-10, CXCL9/MIG, IL-1rа, IL-10, M-CSF, GM-CSF, VEGF-A. We found a significant decrease of nearly all the mentioned cytokines in recovered patients, in comparison with those who had moderate, severe/extremely severe disease. Moreover, we revealed a significantly decreased level of 8 cytokines in plasma from convalescents, as compared with control group, i.e., IL-1α, IL-2, IL-9, IL-12 p40, IL-18, CCL22/MDC, Flt3 Ligand, TGF-α. Immune response caused by SARS-CoV-2 infection involves multiple cytokines, mostly, with pro-inflammatory effects. We have shown for the first time that the convalescence phase is characterized by significantly lower levels of cytokines which regulate cellular differentiation and hematopoiesis (in particular, lymphocytes, T-cells and NK-cells). Over acute phase of the disease, the levels of these cytokines did not change. We revealed a significant decrease of most plasma cytokines upon recovery as compared to acute phase. On the contrary, acute phase of the disease is accompanied by significant increase of both pro- and antiinflammatory cytokines in blood plasma.
A ERA DOS INQUÉRITOS: LIVROS, LEITURA E LEITORES EM SÃO PAULO, ANOS 1920
Authors: Schapochnik Nelson 
Published: May 2021

Este ensaio se debruça sobre um conjunto de textos publicados em revistas e na imprensa dos anos 1920 por um editor (Monteiro Lobato), um crítico literário (José Maria Bello), um ensaísta (Antonio de Alcântara Machado) e um pedagogo (Manoel Bergstrom Lourenço Filho). Embora não seja possível indicar uma relação dialógica entre a totalidade dos textos, a sua leitura cerrada permite destacar algumas afinidades seletivas entre eles. Este elemento comum se traduz na busca de instrumentos de sondagem capazes de produzir dados, apontar tendências e projeções, traçar diagnósticos sobre as práticas editoriais e a formação dos leitores na cidade de São Paulo. Atento simultaneamente à referencialidade e aos modos de argumentação empregados por estes mediadores culturais, é possível compreender a tal Era dos Inquéritos enquanto a scensão de discursos que forjarão uma política cultural visando articular a reflexão sobre os livros e o campo editorial, a formação dos leitores e equipamentos culturais na cidade. Lido de um ponto de vista retrospectivo, a Era dos Inquéritos pode ser considerada como um conjunto de reflexões que forneceram iluminações para a elaboração do programa do Departamento de Cultura e Recreação, dirigido por Mário de Andrade nos anos 30.
Conflictos en las empresas familiares generados por la sucesión
Authors: Gómez-Moreno Nathaly Solanyi  , Botero-Caicedo Yuli Andrea  
Published: May 2021

Las empresas familiares en América Latina son más comunes de lo que se cree, de este tipo de organizaciones se desencadenan relaciones complejas de manejar y los conflictos son una realidad muy marcada cuando se da la sucesión en este tipo de empresas, estos se presentan cuando uno o varios integrantes de la organización sienten que existen desequilibrios, inequidad o preferencias que los afectan, a la hora de designar quien ocupara el liderazgo de la organización a raíz de la sucesión. Los conflictos de este tipo de sociedades por lo regular surgen en la relación que se da desde el núcleo familiar y esto es reflejado en la empresa, en algunos casos el miembro que se siente afectado plantea propuestas para dirimir el conflicto y sus planteamientos pueda que sean atendidos, aceptados y resueltos, con acuerdo y consenso. Es por lo anterior que surge la importancia de investigar dichos conflictos dentro de una organización, ya que si no se les da el manejo adecuado y oportuno la compañía tiende a desaparecer, porque cada uno de los integrantes de la misma trabajaran por un bien propio y no común, que permita que el legado del fundador perdure.
Sobre el suicidio en los profesionales de la salud y la importancia de la creación de estrategias desde un enfoque holístico
Authors: López-Van den Berghe Juanita , Meza-Diaz Francisco Javier , Rojas-Hernández Juan Pablo , Rojas-Fernández Juan Carlos 
Published: May 2021

Es el interés de este artículo analizar y plantear soluciones a disposición de la prevención, sobre la alta frecuencia de intentos y suicidios consumados en el mundo, especialmente en los profesionales de la salud, quienes presentan una mayor tasa de suicidios frente a otras profesiones. Indagando en cuáles son los principales factores de riesgo desde los diferentes ámbitos biopsicosociales y en cómo es la formación de los profesionales de Ciencias de la Salud, esto requiere de un análisis permanente para dar respuesta a las exigencias sociales y económicas del mundo sanitario, las cuales se encuentran en continuo cambio. En un mundo globalizado lleno de incertidumbres y conflictos para los profesionales de la salud, hay que señalar los problemas que surgen respecto a las hipótesis de la cadena de estrés en el área laboral. Se considera que la persistencia del estrés laboral es acumulativa, como lo es el síndrome de Burnout o fatiga crónica, el cual es un factor importante en la tasa de suicidios en los profesionales de la salud.
Impressions of National History: Retracing Panama through Memory Lines
Authors: Amado María Luisa 
Published: May 2021

Abstract
Against the background of the 30th anniversary of the invasion of Panama by U.S. troops, this article analyzes cross-generational differences in how Panamanians evoke and signify this event. Panama’s current climate is ideal to explore this topic, because 2019 also marked 500 years since the foundation of Panama City. This article focuses on how different generations revamp collective memory and relate a story that befits the circumstances of their time. Drawing on informal interviews, secondary data, and relevant aspects of family biography, it examines the interplay between generational drifts and subjective knowledge of Panama. This analysis spotlights how local and transnational processes intersect with biography, shaping perceptions of national history. By the end of the 20th century, U.S. militarized presence in the Panama Canal Zone gave way to a less conspicuous—yet no less significant—influence over Panamanian affairs. Thereupon, past generations’ concern with sovereignty has been overshadowed by a growing focus on the country’s integration in the global economy. While Panamanian millennials are not oblivious to recent U.S. armed intervention, their attitude towards this action is impersonal and dispassionate. Their perception of an increasingly faster course to meet the future dovetails with both a subjective distancing from Panama’s neocolonial history and a growing disconnect from the anti-imperialist discourse of past generations.
“Ni de aquí, ni de allá”: Memory, the Hyphen, and Julia Alvarez’s How the García Girls Lost Their Accents
Authors: Archer Daniel L. 
Published: May 2021

Abstract
One of the intellectual and emotional labors undertaken by children of immigrants is having to negotiate their place in between two different cultures. Existence in this in-between space is understandably challenging and is explored in Julia Alvarez’s How the García Girls Lost Their Accents, as the protagonist Yolanda and her sisters struggle to find themselves in between American and Dominican cultures. This article argues that memory plays a key role in navigating this space, as Alvarez constructs her semi-autobiographical work in reverse chronology, allowing Yolanda to work through the decision of where she believes she fits best using a series of flashbacks and memories from her own eyes and the eyes of other members of her family. While Marianne Hirsch theorizes that postmemory affects generations following those that experienced trauma, what Yolanda experiences differs. The trauma of navigating the “hyphen” of Dominican-American identity is her own, and it is through these memories, in addition to a focus on linguistic differences between English and Spanish that the girls struggle with, we follow Yolanda on her journey of self-discovery. What works such as Alvarez’s How the García Girls Lost Their Accents prove is that individuals have to find peace in an identity that is neither here nor there, ni de aquí ni de allá.
Correction to the article “Abnormal Uterine Bleeding in Adolescents: A Multidisciplinary Approach”, Published on Acta Med Port 2021 Apr;34(4):291-297.
Authors: Ramalho Inês , Leite Helena , Águas Fernanda 
Published: May 2021

On page 293, last paragraph on the left side column, where it reads:“We will discuss in detail the approved pharmacologic agents to treat acute AUB in adolescents, followed by a pharmacologicalmanagement algorithm, taking in consideration the hemodynamic stability and the haemoglobin level.8,9,15” It should read:“We will discuss in detail the approved pharmacologic agents to treat acute AUB in adolescents, followed by a pharmacologicalmanagement algorithm, taking in consideration the hemodynamic stability and the haemoglobin level [Appendix 1 (see Appendix 1: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/12829/Appendix_01.pdf)].8,9,15”Article published with errors: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/12829
POLA KOMUNIKASI PASANGAN SUAMI ISTRI DALAM TEKANAN PASCA MELAHIRKAN DI KOTA BANDAR LAMPUNG
Authors: Kinantri Puspa Sari  , Ramadhana Maulana Rezi 
Published: May 2021

The postpartum period is a transitional period experienced by married couples who require adjustments to the presence of changes in their relationship, especially when the wife is experiencing postpartum stress (depression) during that period. The postpartum period causes changes in conditions followed by changing roles and responsibilities, which can affect the communication relationship between partners. This study focuses on communication patterns of married couples in postpartum pressure using the Interpersonal Communication Patterns Theory approach which is supported by the theory of relationship turbulence. The research method used is a qualitative method with data collection techniques in the form of interviews with four husband and wife couples who live in the city of Bandar Lampung, the determination of the informants is obtained through a snowball sampling strategy (multistage method) with expert informants as data confirmation. The results show that all couples have a separate balanced communication pattern (balanced split pattern) during the face of postpartum stress, which is marked by the division of responsibilities in different roles. In a balanced split communication pattern, all informants experience interferences as well as communication supports, and some experience relationship uncertainty, while constructive strategies are used as approaches in conflict management strategies between partners, characterized by open communication and negotiation. Conflicts related to childcare tasks and lack of quality interactions were the findings of this study.
Abstrak
Periode pasca melahirkan adalah periode transisi yang dialami oleh pasangan suami istri yang membutuhkan upaya penyesuaian dalam hubungan relasi, terlebih saat pihak istri mengalami tekanan/depresi pasca melahirkan selama periode tersebut. Periode pasca melahirkan menimbulkan perubahan kondisi, berupa perubahan peran dan tanggung jawab, yang dapat mempengaruhi hubungan komunikasi di antara pasangan. Penelitian ini berfokus pada pola komunikasi suami-istri dalam tekanan pasca melahirkan dengan metode penelitian kualitatif. Teknik pengambilan data berupa wawancara terhadap empat pasangan suami istri di Bandar Lampung yang didapat dari teknik pengambilan sample snowball sampling, Hasil menunjukkan bahwa seluruh pasangan memiliki pola komunikasi seimbang terpisah selama menghadapi tekanan pasca melahirkan, yang ditandai dengan adanya pembagian tanggung jawab pada peran yang berbeda. Dalam pola komunikasi seimbang terpisah, seluruh informan mengalami hambatan juga dukungan komunikasi, dan sebagian mengalami ketidakpastian hubungan. Sementara, strategi konstruktif digunakan sebagai pendekatan dalam strategi manajemen konflik di antara pasangan, ditandai dengan adanya keterbukaan komunikasi dan negosiasi. Konflik terkait dengan tugas pengasuhan anak dan kurangnya kualitas interaksi menjadi temuan dalam penelitian ini.