bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of High-Intensity Focused Ultrasound Combined With GnRH-a for Adenomyosis: A Systematic Review and Meta-Analysis
Authors: Pang Li-Li , Mei Jin , Fan Ling-Xiu , Zhao Ting-Ting , Li Ruo-Nan , Wen Yi 
Published: August 2021

Objective: High-intensity focused ultrasound (HIFU) is an innovative non-invasive technology used for adenomyosis. Gonadotropin-releasing hormone agonist (GnRH-a) is a hormone commonly used for adenomyosis. We investigated and assessed the efficacy of HIFU combined with GnRH-a for adenomyosis.Methods: For this systematic review and meta-analysis, we searched Pubmed, Cochrane Library, Web of Science, Embase, CNKI, WanFang, and VIP databases for relevant articles published in Chinese or English that compared HIFU combined with GnRH-a vs. HIFU alone in patients with adenomyosis. The last literature search was completed on January 31, 2021. Two reviewers independently assessed study eligibility and assessed risk of bias. Another two reviewers extracted the data. The RevMan5.3 software was used for the data analysis. Changes in volume of the uterine and adenomyotic lesion were defined as the primary outcomes. The secondary outcomes were visual analog scale (VAS) scores for dysmenorrhea, menstrual volume scores, serum CA125 levels, and recurrence rate. This study is registered with PROSPERO (CRD42021234301).Results: Three hundred and ninety potentially relevant articles were screened. Nine studies with data for 766 patients were finally included. Compared with the HIFU alone group, the HIFU combined with GnRH-a group had a higher rate of uterine volume reduction (MD 7.51, 95% CI 5.84–9.17, p &lt; 0.00001), smaller adenomyotic lesion volume (MD 4.11, 95% CI 2.93–5.30, p &lt; 0.00001), lower VAS score for dysmenorrhea (MD 1.27, 95% CI 0.54–2.01, p = 0.0007) and menstrual volume score (MD 0.88, 95% CI 0.73–1.04, p &lt; 0.00001), and lower CA125 level (SMD 0.31, 95% CI 0.05–0.56, p = 0.02) after the procedure. The recurrence rate in the HIFU combined with GnRH-a group was lower than that in the HIFU alone group (RR 0.28, 95% CI 0.10–0.82, p = 0.02).Conclusions: Compared with HIFU treatment alone, HIFU combined with GnRH-a for the treatment of adenomyosis has greater efficacy in decreasing the volumes of the uterine and adenomyotic lesions and alleviating symptoms. However, since the number of the included studies was too small and most of them were written in Chinese, this conclusion needs to be referenced with caution. And the long-term evidence of its efficacy is still insufficient.Systematic Review Registration: https://www.crd.york.ac.uk/prospero/ identifier [CRD42021234].
Clinical and Economic Evaluation of Acupuncture for Opioid-Dependent Patients Receiving Methadone Maintenance Treatment: The Integrative Clinical Trial and Evidence-Based Data
Authors: Wen Hao , Wei Xiaojing , Ge Shuqi , Zeng Jingchun , Luo Wen , Chen Rouhao , Dong Yu , Xiao Songhua , Lai Yunfeng , Lu Liming 
Published: August 2021

Objective: From the health care and societal perspectives, this study aimed to evaluate the clinical and economic effects of acupuncture as an adjunctive therapy for patients receiving methadone maintenance treatment (MMT).Methods: We conducted a parallel-arm RCT in China in 2019. Patients were included who met the diagnostic criteria and receive MMT for more than 30 days. Patients were randomly assigned to the exposed group (acupuncture plus MMT) or control group (MMT) at a 1:1 ratio. Daily methadone dosage, drug cravings using the VAS score, and insomnia using the Pittsburgh Sleep Quality Index (PSQI) were chosen as the effectiveness indexes, and the quality-adjusted life years (QALYs) was chosen as the utility index.Results: Overall, 123 patients were included. The exposed group was significantly (P &lt; 0.05) better than the control group in the improvement of daily methadone dosage (17.68 vs. 1.07), VAS (38.27 vs. 2.64), and PSQI (2.18 vs. 0.30). The QALY was 0.0784 (95%CI: 0.0761–0.0808) for the exposed group and 0.0762 (95%CI: 0.0738–0.0787) for the control group. The total cost of the exposed group (2869.50 CNY) was higher than the control group (2186.04 CNY). The ICER of daily methadone dosage (41.15), VAS (17.86), and PSQI (313.51) were shown to be economically efficient. While ICUR (310,663.64 CNY/QYLY) was higher than the cost suggested by WHO.Conclusion: Acupuncture as an adjuvant therapy for MMT patients realizes its cost-effectiveness by reducing the dosage of methadone, improving drug cravings, and alleviating insomnia. It helps to improve quality of life, but since its cost exceeds what society is willing to pay, further study is needed.
Social Capital Changes After COVID-19 Lockdown Among Youths in China: COVID-19 Impact on Lifestyle Change Survey (COINLICS)
Authors: Yu Bin , Luo Miyang , Liu Meijing , Zhou Junmin , Yang Shujuan , Jia Peng 
Published: August 2021

Introduction: Social capital, the effective functioning of social groups through networks of relationships, can affect mental health and may be affected by COVID-19. We aimed to examine the changes in social capital before and after the COVID-19 lockdown among the Chinese youth.Methods: A national convenience sample of 10,540 high school, undergraduate, and graduate students, from the COVID-19 Impact on Lifestyle Change Survey (COINLICS), reported their demographic and social capital information before and after the COVID-19 lockdown. Social capital was retrospectively measured at four levels: individual (ISC), family (FSC), community (CSC), and society (SSC). The changes of social capital were also compared across three educational levels.Results: Overall, ISC and CSC scores generally decreased after lockdown (15.1 to 14.8 and 13.4 to 13.1, respectively), while FSC and SSC scores increased significantly (12.7 to 13.0 and 7.1 to 7.2, respectively). At the individual level, most participants showed a constant perceived social capital; more of the remaining participants showed decreased than increased ISC (30.5% vs. 17.0%) and CSC scores (28.4% vs. 19.1%), while more participants showed increased than decreased FSC (21.7% vs. 9.2%) and SSC scores (10.3% vs. 3.9%). Heterogeneities in social capital changes existed across educational levels.Conclusions: Our findings would provide health professionals and policy-makers solid evidence on the changes in social capital of youths after lockdowns, and therefore help the design of future interventions to rebuild or improve their social capital after epidemics/disasters.
Histatin 5 Metallopeptides and Their Potential against Candida albicans Pathogenicity and Drug Resistance
Authors: Zolin Gabriela Vieira Silva , Fonseca Fauller Henrique da , Zambom Carolina Reis , Garrido Saulo Santesso 
Published: August 2021

Usually caused by Candida albicans, buccal candidiasis begins with the morphological transition between yeast and hyphal cells. Over time and without the correct treatment, it can be disseminated through the bloodstream becoming a systemic infection with high mortality rates. C. albicans already shows resistance against antifungals commonly used in treatments. Therefore, the search for new drugs capable of overcoming antifungal resistance is essential. Histatin 5 (Hst5) is an antimicrobial peptide of the Histatin family, that can be found naturally in human saliva. This peptide presents high antifungal activity against C. albicans. However, Hst5 action can be decreased for interaction with enzymes and metal ions present in the oral cavity. The current work aims to bring a brief review of relevant aspects of the pathogenesis and resistance mechanisms already reported for C. albicans. In addition, are also reported here the main immune responses of the human body and the most common antifungal drugs. Finally, the most important aspects regarding Histatin 5 and the benefits of its interaction with metals are highlighted. The intention of this review is to show the promising use of Hst5 metallopeptides in the development of effective drugs.
Molecularly Targeted Therapies for Gastric Cancer. State of the Art
Authors: Reddavid Rossella , Dagatti Simona , Franco Caterina , Puca Lucia , Tomatis Mariano , Corso Simona , Giordano Silvia , Degiuli Maurizio 
Published: August 2021

Many phase III trials failed to demonstrate a survival benefit from the addition of molecular therapy to conventional chemotherapy for advanced and metastatic gastric cancer, and only three agents were approved by the FDA. We examined the efficacy and safety of novel drugs recently investigated. PubMed, Embase and Cochrane Library were searched for phase III randomized controlled trials published from January 2016 to December 2020. Patients in the experimental arm received molecular therapy with or without conventional chemotherapy, while those in the control arm had conventional chemotherapy alone. The primary outcomes were overall and progression-free survival. The secondary outcomes were the rate of tumor response, severe adverse effects, and quality of life. Eight studies with a total of 4223 enrolled patients were included. The overall and progression-free survival of molecular and conventional therapy were comparable. Most of these trials did not find a significant difference in tumor response rate and in the number of severe adverse effects and related deaths between the experimental and control arms. The survival benefits of molecular therapies available to date for advanced and metastatic gastric cancer are rather unclear, mostly due to inaccurate patient selection, particularly concerning oncogene amplification and copy number.
A Pipelined Noise-Shaping SAR ADC Using Ring Amplifier
Authors: Lee Juyong , Lee Seungjun , Kim Kihyun , Chae Hyungil 
Published: August 2021

In this study, a pipelined noise-shaping successive-approximation register analog-to-digital converter (PLNS-SAR ADC) structure was proposed to achieve high resolution and to be free from comparator design requirements. The inter-stage amplifier and integrator of the PLNS-SAR ADC were implemented through a ring amplifier with high gain and speed. The ring amplifier was designed to improve power efficiency and be tolerant to process–voltage–temperature (PVT) variation, and uses a single loop common-mode feedback (CMFB) circuit. By processing residual signals with a single ring amplifier, power efficiency can be maximized, and a low-power system with 30% lower power consumption than that of a conventional PLNS-SAR ADC is implemented. With a high-gain ring amplifier, noise leakage is greatly suppressed, and a structure can be implemented that is tolerant of mismatches between the analog loop and digital correction filters. The measured signal to noise distortion ratio (SNDR) is 70 dB for a 5.15 MHz bandwidth (BW) at a 72 MS/s sampling rate (Fs) with an oversampling ratio (OSR) of 7, and the power consumption is 2.4 mW. The FoMS,SNDR (= SNDR + 10log10BW/Power) is 163.5 dB. The proposed structure in this study can achieve high resolution and wide BW with good power efficiency, without a filter calibration process, through the use of a ring amplifier in the PLNS-SAR ADC.
PERAN ORANGTUA DALAM PEMBELAJARAN DARING DIMASA PANDEMI COVID-19
Authors: Lestari Siti , Zifa Minsih 
Published: August 2021

Penelitian ini merupakan penelitian deskriptif kualitatif yang bertujuan untuk mengetahui peran orangtua dalam pembelajaran daring dimasa pandemi covid-19. Penelitian ini mengambil sampel 27 orang sebagai wali murid kelas 3A SD Negeri 1 Panunggalan. Metode penelitian ini menggunakan pendekatan kualitatif dengan metode deskriptif. Data diperoleh dengan menggunakan instrument skala liters berupa angket yang terdiri dari 28 pertanyaan dan berisikan 14 pertanyaan yang negatif dan 14 pertanyaan yang positif. Hasil dari penelitian ini orangtua yang merasa sangat setuju pembelajaran di rumah dapat membantu anak dalam belajar selama pandemic covid 19 sebanyak 5 responden atau 18,52%, orangtua memberikan motivasi kepada anak selama pembelajaran berlangsung di rumah sebanyak 5 responden atau 18,52%, orangtua merasa lebih mudah mengerjakan pekerjaan rumah jika anak belajar di sekolah sebanyak 9 responden atau 33,33%, dan orangtua merasa senang kepada guru yang selalu memberikan tugas kepada anak sebanyak 10 responden atau 37,04%. Sedangkan untuk pernyataan yang negative, orangtua cenderung tidak setuju terhadap pembelajaran yang dilakukan dirumah. Hasil dari pernyataan negative yaitu pembelajaran di sekolah kurang dapat meningkatkan kualitas pembelajaran anak sebanyak 23 responden atau 85,18%, orangtua tidak pernah memberikan motivasi selama anak belajar di rumah sebanyak 22 responden atau 81,48%, dan orangtua tidak pernah membantu anak belajar sebanyak 21 responden atau 77,78%. Dapat disimpulkan bahwa pembelajaran di rumah tidak jauh lebih baik daripada pembelajaran di sekolah.
Regulasi Emosi terhadap Kecemasan Tahanan
Authors: Sari Silmi Sagita , Sumarna Nana , Kaimuddin Sitti Mikarna 
Published: August 2021

Hidup dalam Rutan dapat menimbulkan kecemasan bagi tahanan. Kecemasan merupakan bentuk emosi negatif. Kondisi ini merupakan hal yang dapat berdampak buruk bagi tahanan sehingga diperlukan alternatif atau cara dalam mengatur emosi negatif tersebut. Dengan regulasi emosi, tahanan mampu untuk mengatur serta mengelola emosi negatif menjadi emosi positif. Penelitian dilakukan dengan tujuan untuk mengetahui peran regulasi emosi terhadap kecemasan tahanan Rutan Kelas IIA Kendari. Jenis penelitian yang digunakan adalah kuantitatif ex-post facto dengan teknik purpossive sampling dengan kriteria subjek dengan usia 20-50 tahun sehingga didapatkan jumlah sampel sebanyak 107 subjek. Pengumpulan data dilakukan dengan penyebaran skala regulasi emosi dan skala kecemasan. Data hasil penelitian dianalisis dengan menggunakan analisis regresi untuk melihat peran variabel X terhadap variabel Y. Hasil penelitian menunjukkan regulasi emosi paling banyak dialami pada kategori sedang sebanyak 65% sedangkan kecemasan sebanyak 64%. Koefisien determinasi R square sebesar 17,7% dimana regulasi emosi menyumbang nilai efektif sebesar 17,7%. Koefisien korelasi menunjukan nilai negatif negatif dimana hal ini menjelaskan semakin tinggi regulasi emosi maka semakin rendah kecemasan sehingga pengajuan hipotesis diterima.
ANTIMONOPOLY REGULATION IN THE SYSTEM OF STATE REGULATION OF ENTREPRENEURSHIP
Authors: Эрганов Юрий Тарасович 
Published: August 2021

В статье исследуются механизмы антимонопольного регулирования в системе государственного регулирования предпринимательской деятельности. Проанализированы основания государственного воздействия на предпринимательство. Рассмотрена система нормативно-правового регулирования в сфере защиты конкуренции и противодействия монополизму.
The article examines the mechanisms of antimonopoly regulation in the system of state regulation of entrepreneurial activity. The grounds of state influence on entrepreneurship are analyzed. The system of legal regulation in the field of competition protection and counteraction to monopolism is considered.
STRUCTURAL AND SEMANTIC PECULIARITIES OF ENGLISH ZOONYMIC PHRASEOLOGICAL UNITS
Authors: Шамилева Разета Дадуевна , Алиева Зара Алвиевна 
Published: August 2021

Статья представляет результаты структурного и семантического анализа зоонимических фразеологизмов английского языка. С точки зрения семантики все фразеологизмы поделены на две большие группы (c домашними и дикими животными); проанализированы способы образования фразеологизмов с компонентом-зоонимом, представлен семантический анализ фразеологизмов с наиболее частотными номинантами-зоонимами.The article presents the results of a structural and semantic analysis of zoonymic phraseological units of the English language. From the point of view of semantics, all phraseological units are divided into two large groups (with domestic and wild animals); methods of forming phraseological units with a zoonym component are analyzed. The article presents a semantic analysis of phraseological units with the most frequent nominees-zoonyms.
MINIMIZATION OF LOGICAL EXPRESSIONS IN PROBLEMS OF DESIGNING COMBINATIONAL SCHEMES
Authors: Попова Ксения Владимировна , Малышева Елена Николаевна 
Published: August 2021

В статье рассматривается минимизация логических выражений как один из этапов решения задач, связанных с проектированием комбинационных электронных схем. Такие практико-ориентированные задачи демонстрируют межпредметные связи математики, информатики и электроники. Они являются средством развития технического мышления и политехнического воспитания школьников.
This article deals with the minimization of logical expressions as one of the stages of solving problems associated with the design of combinational electronic circuits. Such practice-oriented tasks demonstrate the intersubject connections of mathematics, computer science and electronics. They are a means of developing technical thinking and polytechnic education of students.
MINIMIZING LOGICAL EXPRESSIONS IN A SCHOOL COMPUTER SCIENCE COURSE
Authors: Попова Ксения Владимировна , Малышева Елена Николаевна 
Published: August 2021

В статье представлен анализ учебников по информатике (10-11 класс) по теме «Минимизация логических выражений». Его результаты могут быть использованы при проектировании работы по углубленной подготовке старшеклассников с учетом межпредметных связей и практико-ориентированного подхода к обучению.
In this article an analysis of Information Technology books (10-11 grades) on the topic "Minimization of logical expressions" is represented. Its results can be used in the design of work on in-depth training of high school students, taking into account intersubject connections and a practice-oriented approach to teaching.
FUNCTIONS OF METATEXT AT THE LEVEL OF THE POETIC CYCLES IN THE LYRICS OF B.L. PASTERNAK
Authors: Царева Нина Александровна 
Published: August 2021

В статье анализируются особенности употребления самостоятельного лирического текста как метатекстового «оператора» в пространстве поэтического цикла зрелой лирики Б. Пастернака. Метатекст рассматривается как средство авторской самооценки на пути глобального познания мира через страдание, гибель и возрождение лирического героя последних поэтических опусов великого русского поэта.
The article analyzes the features of the use of an independent lyric text as a metatext "operator" in the space of the poetic cycle of B. Pasternak's mature lyrics. The metatext is viewed as a means of the author's self-esteem on the path of global knowledge of the world through suffering, death and revival of the lyric hero of the last poetic opuses of the great Russian poet. .
ON THE PROBLEM OF ASSESSING THE QUALITY OF FUNCTIONAL LITERACY
Authors: Высоцкая Елена Викторовна , Лобанова Анастасия Денисовна , Янишевская Мария Алексеевна 
Published: August 2021

Исследовано качество формирования функциональной грамотности у учащихся начальной школы на примере решения арифметических задач. Показано, что усложнение словесной формулировки задачи (без изменения «математической» составляющей) приводит к статистически значимому уменьшению качества ее решения учащимися 3 и 4 классов.
The quality of the formation of functional literacy in primary school students is studied by the example of solving arithmetic problems. It is shown that the complexity of the verbal formulation of the problem (without changing the "mathematical" component) leads to a statistically significant decrease in the quality of its solution by students of grades 3 and 4.
TO THE QUESTION OF LEGAL ASSURANCE OF QUALITY EDUCATIONAL PROCESS: ANALYSIS OF EDUCATIONAL STANDARDS
Authors: Касьянова Елена Васильевна 
Published: August 2021

Выполнен сравнительный анализ федеральных образовательных стандартов третьего поколения по направлению подготовки 09.03.01 «Информатика и вычислительная техника». Проанализированы изменения в содержании. Продемонстрирована преемственность федеральных государственных образовательных стандартов и выявлены факторы, определяющие необходимость их модернизации.
A comparative analysis of the federal educational standards of the third generation in the direction of training 09.03.01 "Informatics and computer technology" is carried out. The changes in the content are analyzed. The continuity of federal state educational standards is demonstrated and the factors that determine the need for their modernization are revealed.
QUESTIONS OF CONSTRUCTIVISM IN THE THEORIES OF MASS COMMUNICATIONS
Authors: Костромитина Мария Андреевна 
Published: August 2021

В данной статье рассматриваются теоретические аспекты конструктивизма в теориях массовых коммуникаций, основанные на синтезе различных научных достижений, в настоящее время играют важную роль в вопросах конструирования медиареальности и сохраняют специфику и традиции медиаисследований. Автор предпринимает попытку обобщить различные подходы теоретических исследований по проблемам конструктивизма.
This article examines the theoretical aspects of constructivism in mass communication theories, based on the synthesis of various scientific achievements, which currently play an important role in the construction of media reality and preserve the specifics and traditions of media research. The author attempts to generalize various approaches of theoretical research on the problems of constructivism.
TO THE CONCEPT OF THE MECHANISM FOR IMPLEMENTING THE RIGHTS OF A MINOR
Authors: Умарова Мадина Алиевна 
Published: August 2021

В статье рассматривается специфика, формы и уровни механизма защиты прав несовершеннолетних как особой категории граждан. Автор затрагивает проблемы, затрудняющие эффективность действия правовой защиты прав ребенка.
The article examines the specifics, forms and levels of the mechanism for protecting the rights of minors as a special category of citizens. The author touches upon the problems that hinder the effectiveness of the legal protection of the rights of the child.
LEGAL FRAMEWORK FOR COUNTERING TERRORISM IN THE RUSSIAN FEDERATION
Authors: Ганаева Есита Эминовна 
Published: August 2021

Настоящая статья направлена на рассмотрение теоретических и правовых основ противодействия терроризму, поскольку именно в теории закладываются основы указанной деятельности, получающие дальнешую реализацию на практике.
This article is aimed at examining the theoretical and legal foundations of countering terrorism, since it is in theory that the foundations of this activity are laid, which are further implemented in practice.
SOME ASPECTS OF CHILD’S INVOLVEMENT IN LEGAL RELATIONS OF HEREDITORY SUCCESSION
Authors: Умарова Амала Алиевна 
Published: August 2021

В статье рассматриваются теоретические вопросы наследственного правопреемства. Определяются признаки наследственного правопреемства: гражданин является умершим (смерть гражданина порождает два основных последствия: его правоспособность прекращается, начинается процесс наследования), любое имущество наследодателя переходит к другим лицам, наследование является универсальным правопреемством.
The article deals with theoretical issues of hereditary succession. The characteristics of hereditary succession are defined as following: the citizen is dead (death of a citizen produces two main effects: its capacity is terminated, the process of inheritance starts), any property of the testator passes to others, inheritance is a universal succession.
PITIRIM SOROKIN AS A NONCONFORMIST
Authors: Босов Дмитрий Вячеславович , Анкудинов Александр Львович , Устинова Екатерина Евгеньевна , Федорова Мария Анатольевна 
Published: August 2021

Цель статьи: рассмотреть позицию П. Сорокина как нонконформиста в социологии. Методы: компаративистский, исторический, биографический. Результаты: выявлены основные вехи проявления нонконформистских позиций ученого в жизни и в науке. Выводы: Нонконформизм ученого стал двигателем научного поиска П.А. Сорокина.Purpose of the article: to consider the position of P. Sorokin as a nonconformist in sociology. Methods: comparative, historical, biographical. Results: the main milestones in the manifestation of the scientist's non-conformist positions in life and in science were revealed. Conclusions: The scientist's nonconformism became the engine of P.A. Sorokin.