bluuebunny/crossref_metadata_2025_split huggingface dataset:
The lived experience of people with obesity: study protocol for a systematic review and synthesis of qualitative studies
Authors: Farrell Emma , Bustillo Marta , le Roux Carel W. , Nadglowski Joe , Hollmann Eva , McGillicuddy Deirdre 
Published: June 2021

Abstract
Background
Obesity is a prevalent, complex, progressive and relapsing chronic disease characterised by abnormal or excessive body fat that impairs health and quality of life. It affects more than 650 million adults worldwide and is associated with a range of health complications. Qualitative research plays a key role in understanding patient experiences and the factors that facilitate or hinder the effectiveness of health interventions. This review aims to systematically locate, assess and synthesise qualitative studies in order to develop a more comprehensive understanding of the lived experience of people with obesity.

Methods
This is a protocol for a qualitative evidence synthesis of the lived experience of people with obesity. A defined search strategy will be employed in conducting a comprehensive literature search of the following databases: PubMed, Embase, PsycInfo, PsycArticles and Dimensions (from 2011 onwards). Qualitative studies focusing on the lived experience of adults with obesity (BMI >30) will be included. Two reviewers will independently screen all citations, abstracts and full-text articles and abstract data. The quality of included studies will be appraised using the critical appraisal skills programme (CASP) criteria. Thematic synthesis will be conducted on all of the included studies. Confidence in the review findings will be assessed using GRADE CERQual.

Discussion
The findings from this synthesis will be used to inform the EU Innovative Medicines Initiative (IMI)-funded SOPHIA (Stratification of Obesity Phenotypes to Optimize Future Obesity Therapy) study. The objective of SOPHIA is to optimise future obesity treatment and stimulate a new narrative, understanding and vocabulary around obesity as a set of complex and chronic diseases. The findings will also be useful to health care providers and policy makers who seek to understand the experience of those with obesity.

Systematic review registration
PROSPERO CRD42020214560.
Blockchain-based trust management in cloud computing systems: a taxonomy, review and future directions
Authors: Li Wenjuan , Wu Jiyi , Cao Jian , Chen Nan , Zhang Qifei , Buyya Rajkumar 
Published: June 2021

AbstractThrough virtualization and resource integration, cloud computing has expanded its service area and offers a better user experience than the traditional platforms, along with its business operation model bringing huge economic and social benefits. However, a large amount of evidence shows that cloud computing is facing with serious security and trust crisis, and building a trust-enabled transaction environment has become its key factor. The traditional cloud trust model usually adopts a centralized architecture, which causes large management overhead, network congestion and even single point of failure. Furthermore, due to a lack of transparency and traceability, trust evaluation results cannot be fully recognized by all participants. Blockchain is a new and promising decentralized framework and distributed computing paradigm. Its unique features in operating rules and traceability of records ensure the integrity, undeniability and security of the transaction data. Therefore, blockchain is very suitable for constructing a distributed and decentralized trust architecture. This paper carries out a comprehensive survey on blockchain-based trust approaches in cloud computing systems. Based on a novel cloud-edge trust management framework and a double-blockchain structure based cloud transaction model, it identifies the open challenges and gives directions for future research in this field.
Risk factors associated with mechanical ventilation, autonomic nervous dysfunction and physical outcome in Vietnamese adults with tetanus
Authors: Davies-Foote Rachel , Trung Truong Ngoc , Duoc Nguyen Van Thanh , Duc Du Hong , Nhat Phung Tran Huy , Trang Vo Thi Nhu , Anh Nguyen Thi Kim , Lieu Pham Thi , Thuy Duong Bich , Phong Nguyen Thanh , Truong Nguyen Thanh , Thanh Pham Ba , Tam Dong Thi Hoai , Thuy Tran Thi Diem , Tuyen Pham Thi , Tan Thanh Tran , Campbell James , Le Van Tan  , Puthucheary Zudin , Yen Lam Minh , Van Hao Nguyen , Thwaites C. Louise 
Published: June 2021

Abstract
Background
Tetanus remains common in many low- and middle-income countries, but as critical care services improve, mortality from tetanus is improving. Nevertheless, patients develop severe syndromes associated with autonomic nervous system disturbance (ANSD) and the requirement for mechanical ventilation (MV). Understanding factors associated with worse outcome in such settings is important to direct interventions. In this study, we investigate risk factors for disease severity and long-term physical outcome in adults with tetanus admitted to a Vietnamese intensive care unit.

Methods
Clinical and demographic variables were collected prospectively from 180 adults with tetanus. Physical function component scores (PCS), calculated from Short Form Health Survey (SF-36), were assessed in 79 patients at hospital discharge, 3 and 6 months post discharge.

Results
Age, temperature, heart rate, lower peripheral oxygen saturation (SpO2) and shorter time from first symptom to admission were associated with MV (OR 1.03 [ 95% confidence interval (CI) 1.00, 1.05], p = 0.04; OR 2.10 [95% CI 1.03, 4.60], p = 0.04; OR 1.04 [ 95% CI 1.01, 1.07], p = 0.02); OR 0.80 [95% CI 0.66, 0.94], p = 0.02 and OR 0.65 [95% CI 0.52, 0.79, p < 0.001, respectively).
Heart rate, SpO2 and time from first symptom to admission were associated with ANSD (OR 1.03 [95% CI 1.01, 1.06], p < 0.01; OR 0.95 [95% CI 0.9, 1.00], p = 0.04 and OR 0.64 [95% CI 0.48, 0.80], p < 0.01, respectively).
Median [interquartile range] PCS at hospital discharge, 3 and 6 months were 32.37 [24.95–41.57, 53.0 [41.6–56.3] and 54.8 [51.6–57.3], respectively. Age, female sex, admission systolic blood pressure, admission SpO2, MV, ANSD, midazolam requirement, hospital-acquired infection, pressure ulcer and duration of ICU and hospital stay were associated with reduced 0.25 quantile PCS at 6 months after hospital discharge.

Conclusions
MV and ANSD may be suitable endpoints for future research. Risk factors for reduced physical function at 3 months and 6 months post discharge suggest that modifiable features during hospital management are important determinants of long-term outcome.
Linearization threshold condition and stability analysis of a stochastic dynamic model of one-machine infinite-bus (OMIB) power systems
Authors: Li Lijuan , Chen Yongdong , Zhou Bin , Liu Hongliang , Liu Yongfei 
Published: June 2021

AbstractWith the increase in the proportion of multiple renewable energy sources, power electronics equipment and new loads, power systems are gradually evolving towards the integration of multi-energy, multi-network and multi-subject affected by more stochastic excitation with greater intensity. There is a problem of establishing an effective stochastic dynamic model and algorithm under different stochastic excitation intensities. A Milstein-Euler predictor-corrector method for a nonlinear and linearized stochastic dynamic model of a power system is constructed to numerically discretize the models. The optimal threshold model of stochastic excitation intensity for linearizing the nonlinear stochastic dynamic model is proposed to obtain the corresponding linearization threshold condition. The simulation results of one-machine infinite-bus (OMIB) systems show the correctness and rationality of the predictor-corrector method and the linearization threshold condition for the power system stochastic dynamic model. This study provides a reference for stochastic modelling and efficient simulation of power systems with multiple stochastic excitations and has important application value for stability judgment and security evaluation.
Demystifying genetic jargon in psychiatry
Authors: Mizen Lindsay A. M. 
Published: June 2021

SUMMARYGenetic testing in psychiatry is becoming more common, but psychiatrists often receive little training in it. Given the pace of change in genetics, understanding the current methods of testing and their associated merits and limitations can therefore be challenging for some. This narrative, written for psychiatrists in the clinic, aims to cut through the jargon and describe current genetic testing techniques and their evolution from previous methods. It discusses benefits and risks of testing, how geneticists decide whether genetic variants are pathogenic, terminology found in genetic test results and how best to support patients with genetic diagnoses. It also describes methods used to study the genetics of polygenic disorders. It is anticipated this will facilitate a greater understanding of genetic testing and promote confidence among psychiatrists to discuss its clinical utility and implications with patients.
Randomized Trial of Two Induction Therapy Regimens for High-Risk Neuroblastoma: HR-NBL1.5 International Society of Pediatric Oncology European Neuroblastoma Group Study
Authors: Garaventa Alberto , Poetschger Ulrike , Valteau-Couanet Dominique , Luksch Roberto , Castel Victoria , Elliott Martin , Ash Shifra , Chan Godfrey C. F. , Laureys Geneviève , Beck-Popovic Maja , Vettenranta Kim , Balwierz Walentyna , Schroeder Henrik , Owens Cormac , Cesen Maja , Papadakis Vassilios , Trahair Toby , Schleiermacher Gudrun , Ambros Peter , Sorrentino Stefania , Pearson Andrew D. J. , Ladenstein Ruth Lydia 
Published: June 2021

PURPOSE Induction therapy is a critical component of the therapy of high-risk neuroblastoma. We aimed to assess if the Memorial Sloan Kettering Cancer Center (MSKCC) N5 induction regimen (MSKCC-N5) would improve metastatic complete response (mCR) rate and 3-year event-free survival (EFS) compared with rapid COJEC (rCOJEC; cisplatin [C], vincristine [O], carboplatin [J], etoposide [E], and cyclophosphamide [C]). PATIENTS AND METHODS Patients (age 1-20 years) with stage 4 neuroblastoma or stage 4/4s aged < 1 year with MYCN amplification were eligible for random assignment to rCOJEC or MSKCC-N5. Random assignment was stratified according to national group and metastatic sites. Following induction, therapy comprised primary tumor resection, high-dose busulfan and melphalan, radiotherapy to the primary tumor site, and isotretinoin with ch14.18/CHO (dinutuximab beta) antibody with or without interleukin-2 immunotherapy. The primary end points were mCR rate and 3-year EFS. RESULTS A total of six hundred thirty patients were randomly assigned to receive rCOJEC (n = 313) or MSKCC-N5 (n = 317). Median age at diagnosis was 3.2 years (range, 1 month to 20 years), and 16 were younger than 1 year of age with MYCN amplification. mCR rate following rCOJEC induction (32%, 86/272 evaluable patients) was not significantly different from 35% (99/281) with MSKCC-N5 ( P = .368), and 3-year EFS was 44% ± 3% for rCOJEC compared with 47% ± 3% for MSKCC-N5 ( P = .527). Three-year overall survival was 60% ± 3% for rCOJEC compared with 65% ± 3% for MSKCC-N5 ( P = .379). Toxic death rates with both regimens were 1%. However, nonhematologic CTC grade 3 and 4 toxicities were higher with MSKCC-N5: 68% (193/283) versus 48% (129/268) ( P < .001); infection 35% versus 25% ( P = .011); stomatitis 25% versus 3% ( P < .001); nausea and vomiting 17% versus 7% ( P < .001); and diarrhea 7% versus 3% ( P = .011). CONCLUSION No difference in outcome was observed between rCOJEC and MSKCC-N5; however, acute toxicity was less with rCOJEC, and therefore rCOJEC is the preferred induction regimen for International Society of Pediatric Oncology European Neuroblastoma Group.
Text and Document in Dante’s Vita nova
Authors: Del Puppo Dario 
Published: June 2021

Abstract
This article considers the importance of material philological features of the early manuscripts of Dante’s Vita nova for the work’s critical reception. Over the centuries, editors (most notably Giovanni Boccaccio) have recast textual meaning in the work mainly by marginalizing the poet’s glosses and by reformatting the poems. Attention to the material features of the earliest extant manuscript of the Vita nova (MS Martelli 12) with respect to later copies, however, prompts us to consider the creative interplay between Dante’s prosimetrum and the material features of the manuscript. To interpret a text critically is to acknowledge and to examine also how a manuscript or print edition orients textual interpretation. The editorial history of the Vita nova teaches us about the cultural processes and discourses of literary culture and about Italian literary history.
Cultural Mediations and Material Contexts of Dante’sCommedia:The Case of Beinecke MS 428
Authors: Magni Isabella 
Published: June 2021

AbstractThe textual and cultural interpretations related to the material construction of the first manuscript copies of Dante’s Commedia play a crucial role in shaping its transmission and inevitably also the text that we read today. The processes of preparation and the material structures of these codices, in fact, often reflect more the culture in which they were created than the culture of the original work itself. Starting from a reflection about issues of cultural mediations and material contexts of the early diffusion of Dante’s Commedia, this article introduces a new case study: fourteenth-century manuscript Beinecke Library MS 428, a deluxe copy commissioned by the Bini family.
Painting (and Writing) over Dante
Authors: Storey H. Wayne 
Published: June 2021

Abstract
With the advent of studies in the area of mise-en-page and the increased interest in the relationships among text, image, and material structures in medieval manuscripts, the inherent problems of interpretation and “intentionality” have often been concentrated in critics’ assignment of meaning and cultural “readings” to medieval illuminators. Yet numerous sources, especially the instructions to illuminators that remain still visible in unfinished manuscripts, confirm that methods of work in the illustrating of medieval texts were guided by very different criteria than interpretation. Instead, the material and mechanical realities of reproducing medieval texts, among them Dante’s Commedia, were often subject more to production efficiency, cost effectiveness, taste, and scribal and cultural norms. Examining the instructions to the illuminator of an unfinished copy of a uniquely edited Veneto copy of the Commedia, initially produced in the 1340s (Codex Italicus 1 of the University Library and Archives of Eötvös Loránd University in Budapest), this essay investigates the systems and constructions imposed on the Commedia by a new scribal culture in the reproduction and “visual glossing” of the poem.
Molecular models of LINC complex assembly at the nuclear envelope
Authors: Jahed Zeinab , Domkam Nya , Ornowski Jessica , Yerima Ghafar , Mofrad Mohammad R. K. 
Published: June 2021

ABSTRACT
Large protein complexes assemble at the nuclear envelope to transmit mechanical signals between the cytoskeleton and nucleoskeleton. These protein complexes are known as the linkers of the nucleoskeleton and cytoskeleton complexes (LINC complexes) and are formed by the interaction of SUN and KASH domain proteins in the nuclear envelope. Ample evidence suggests that SUN–KASH complexes form higher-order assemblies to withstand and transfer forces across the nuclear envelope. Herein, we present a review of recent studies over the past few years that have shed light on the mechanisms of SUN–KASH interactions, their higher order assembly, and the molecular mechanisms of force transfer across these complexes.
L-fuzzy cosets in universal algebras
Authors: Addis Gezahagne Mulat 
Published: June 2021

AbstractIn this paper, we introduce the notion of fuzzy costs in a more general context, in universal algebra by the use of coset terms. We study the structure of fuzzy cosets by applying the general theory of algebraic fuzzy systems. Fuzzy cosets generated by a fuzzy set are characterized in different ways. It is also proved that the class of fuzzy cosets determined by an element forms an algebraic closure fuzzy set system. Finally, we give a set of necessary and sufficient conditions for a given variety of algebras to be congruence permutable by applying the theory of fuzzy cosets.
Jordan amenability of banach algebras
Authors: Valaei Mohammad , Zivari-Kazempour Abbas , Bodaghi Abasalt 
Published: June 2021

AbstractIn this paper, we introduce and study the concepts of Jordan amenability and Jordan biflatness of Banach algebras and compare those with the classical notions of amenability and biflatness. We also find some relations between Jordan amenability and the existence of Jordan approximate and virtual diagonals. These could be considered as Jordan versions of the classical results due to Johnson and Helemskii. We show that, for allC*-algebras, the concepts of amenability and Jordan amenability coincide.
Primary hepatic neuroendocrine tumor
Authors: Tuan Linh Le , Minh Duc Nguyen , Tu Minh Hoang , Ngoc Cuong Nguyen , Thu Ha Vuong , Luan Dao-Thi , Tra My Thieu-Thi , Van Lenh Bui 
Published: June 2021

Summary
Primary hepatic neuroendocrine tumor (PHNET) is a rare type of neuroendocrine tumor (NET) that is also a primary hepatic tumor. Patients are present with almost no specific clinical symptoms and typically present with negative test results and atypical imaging characteristics; therefore, the differentiation of PHNET from other types of primary hepatic masses can be very difficult. In this article, we describe a case of PHNET that mimicked a liver helminth infection in a 57-year-old man. The diagnosis of PHNET in this patient was challenging, and the final diagnosis was based on imaging, histopathology features, and long-term follow-up.

Learning points

An uncommon type of neuroendocrine tumor (NET) is a primary hepatic neuroendocrine tumor (PHNET).

Primary hepatic neuroendocrine tumors are rare NET lesions found in the liver, characterized by non-specific clinical and imaging results, which can be easily confused with other liver lesions, including HCC and parasitic lesions.

To have a conclusive diagnosis and classification, a mixture of many medical assessment techniques, such as imaging, gastrointestinal endoscopy, nuclear medicine, anatomy, including histopathology, and immunohistochemistry, is essential.
A National Mental Health Profile of Parents of Children With Medical Complexity
Authors: Bayer Nathaniel D. , Wang Hongyue , Yu Justin A. , Kuo Dennis Z. , Halterman Jill S. , Li Yue 
Published: June 2021

OBJECTIVES
The mental health of parents of children with medical complexity (CMC) is poorly understood, yet it drives child and family health outcomes. For parents of CMC, compared with parents of noncomplex children with special health care needs (CSHCN) and children without special health care needs (non-CSHCN), we examined self-reported mental health, knowledge of community sources for help, and emotional support.

METHODS
Using parent-reported data from the combined 2016–2017 National Survey of Children’s Health, we divided the population into 3 groups: households with CMC, noncomplex CSHCN, and non-CSHCN. We compared these groups regarding the following: (1) parents’ risks for poor or fair mental health and knowledge of where to go for community help and (2) parent-reported sources of emotional support.

RESULTS
Of 63 955 588 parent-child dyads (weighted from a sample of 65 204), parents of CMC had greater adjusted odds of reporting poor or fair mental health compared with parents of noncomplex CSHCN (adjusted odds ratio [aOR] 2.0; 95% confidence interval [CI] 1.1–3.8) and non-CSHCN (aOR 4.6; 95% CI 2.5–8.6). Parents of CMC had greater odds of not knowing where to find community help compared with parents of noncomplex CSHCN (aOR 2.1; 95% CI 1.4–3.1) and non-CSHCN (aOR 2.9; 95% CI 2.0–4.3). However, parents of CMC were most likely to report receiving emotional support from health care providers and advocacy groups (P &lt; .001).

CONCLUSIONS
Among all parents, those with CMC were at the highest risk to report suboptimal mental health. They more often reported that they do not know where to find community help, but they did say that they receive emotional support from health care providers and advocacy groups. Future researchers should identify ways to directly support the emotional wellness of parents of CMC.
Motivated attention to stimuli related to social networking sites: A cue-reactivity study
Authors: Moretta Tania , Buodo Giulia 
Published: June 2021

AbstractBackground and aimsIt has been argued that similar to addictive behaviors, problematic Social Network sites use (PSNSU) is characterized by sensitized reward processing and cue-reactivity. However, no study to our knowledge has yet investigated cue-reactivity in PSNSU. The present study aims at investigating cue-reactivity to Social Network sites (i.e., Facebook)-related visual cues in individuals identified as problematic vs. non-problematic Facebook users by the Problematic Facebook Use Scale.MethodsThe Event-Related Potentials (ERPs) were recorded during the passive viewing of Facebook-related, pleasant, unpleasant, and neutral pictures in 27 problematic and 26 non-problematic users. Moreover, craving for Facebook usage was collected using a Likert scale.ResultsDespite problematic users were more likely to endorse higher craving than non-problematic ones, Facebook-related cues elicited larger ERP positivity (400–600 ms) than neutral, and comparable to unpleasant stimuli, in all Facebook users. Only in problematic users we found larger positivity (600–800 ms) to pleasant than unpleasant cues and higher craving to be related with lower later positivity (800–1,000 ms) to pleasant and unpleasant cues.DiscussionRegardless of whether Facebook usage is problematic or non-problematic, Facebook-related cues seem to be motivationally relevant stimuli that capture attentional resources in the earlier stages of “motivated” attentional allocation. Moreover, our results support the view that in higher-craving problematic users, reduced abilities to experience emotions would be the result of defective emotion regulation processes that allow craving states to capture more motivational/attentional resources at the expense of other emotional states.
Transnistria's public health system and SARS-CoV-2: The challenges of an unrecognized state facing a global pandemic
Authors: Vlas Cristian 
Published: June 2021

Abstract
The paper presents a comprehensive overview of the public health system in the separatist Trasnistrian region of Moldova, an analytically unorthodox undertaking, as this entails looking at the health system of a fragile breakaway state-like entity, a set of circumstances that — rather inevitably, it seems — may define certain basic features of the health system at hand. Attention will be dedicated to outlining the main challenges the region's public health system faces, for instance, concerning the spread of infectious diseases such as tuberculosis, HIV/AIDS, and SARS-CoV-2. Studying the impact of the coronavirus pandemic can especially serve as a litmus test of the available capacities in Transnistria to deal with public health challenges: facing a novel pathogen, and the related disease and epidemic which threaten to overburden the local institutions. A key question examined here, through the example of Transnistria, is the degree to which international support to the region and the increasing cooperation with the internationally recognized state of Moldova are indispensable for public health security in the unrecognized state.