bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eusebius of Caesarea, the Roman Empire, and the Fulfillment of Biblical Prophecy: Reassessing Byzantine Imperial Eschatology in the Age of Constantine
Authors: Bonura Christopher 
Published: December 2021

AbstractModern scholarship often attributes to Eusebius of Caesarea (d. circa 340 AD) the view that God's heavenly kingdom had become manifest in the Roman Empire of Constantine the Great. Consequently, Eusebius is deemed significant in the development of Christian eschatological thought as the supposed formulator of a new “realized eschatology” for the Christian Roman Empire. Similarly, he is considered the originator of so-called “Byzantine imperial eschatology”—that is, eschatology designed to justify the existing imperial order under the emperors in Constantinople. Scholars advancing these claims most frequently cite a line from Eusebius's Tricennial Oration in which he identified the accession of the sons of Constantine with the prophesied kingdom of the saints in the Book of Daniel. Further supposed evidence has been adduced in his other writings, especially his Life of Constantine. This article argues that this common interpretation of Eusebius's eschatology is mistaken and has resulted from treating a few passages in isolation while overlooking their rhetorical context. It demonstrates instead that Eusebius adhered to a conventional Christian eschatology centered on the future kingdom of heaven that would accompany the second coming of Christ and further suggests that the concept of “Byzantine imperial eschatology” should be reconsidered.
Connecting perception and production in early Catalan–Spanish bilingual children: language dominance and quality of input effects
Authors: RAMON-CASAS Marta , CORTÉS Susana , BENET Ariadna , LLEÓ Conxita , BOSCH Laura 
Published: December 2021

AbstractThis study investigates perception and production of the Catalan mid-vowel /e/-/ɛ/ contrast by two groups of 4.5-year-old Catalan–Spanish bilingual children, differing in language dominance. Perception was assessed with an XAB discrimination task involving familiar words and non-words. Production accuracy was measured using a familiar-word elicitation task. Overall, Catalan-dominant bilingual children outperformed Spanish-dominant bilinguals, the latter showing high variability in production accuracy, while being slightly above chance level in perception. No correlation between perception and production performance could be established in this group. The effect of language dominance alone could not explain the Spanish-dominant participants’ performance, but quality of Catalan input (native vs. accented speech) was identified as an important factor behind familiar-word production and the inaccurate representation of the target contrast in the lexicon of the bilinguals’ less-dominant language. More fine-grained measurements of experience-related factors are needed for a full understanding of the acquisition of challenging contrasts in bilingual contexts.
Emergency Preparedness and Disaster Response: There’s an App for That 2.0
Authors: McAtee Kyle J. , Bedenbaugh Robert , Lakis Dorothy (Christie) , Bachmann Daniel J. , Kman Nicholas E. 
Published: December 2021

AbstractIntroduction:In disaster response, smartphone applications (or apps) are being used by the layperson, emergency first responders, and health care providers to aid in everything from incident reporting to clinical decision making. However, quality apps are often diluted by the overwhelming number of apps that exist for both the lay public and first responders in the Apple iTunes (Apple Inc.; Cupertino, California USA) and Google Play (Google LLC; Mountain View, California USA) stores.Hypothesis/Problem:A systematic review of disaster response apps was originally completed in 2015; a follow-up review was completed here to evaluate trends and explore novel apps.Methods:A search of the Apple iTunes and Google Play stores was performed using the following terms obtained from PubMed (National Center for Biotechnology Information; Bethesda, Maryland USA) Medical Subject Headings Database: Emergency Preparedness; Emergency Responders; Disaster; Disaster Planning; Disaster Medicine; Bioterrorism; Chemical Terrorism; Hazardous Materials; and the Federal Emergency Management Agency (FEMA [Washington, DC USA]). After excluding any unrelated apps, a working list of apps was formed and categorized based on topics. Apps were categorized by intended user (first responders or the public) and sub-categorized by topic for discussion. Sub-categories included News/Information, Reference/Education, Weather/Natural Disasters, Travel/Navigation, and Communication/Reunification.Results:A search of the Apple iTunes store revealed 394 unique apps and was narrowed to 342 based on relevance to the field and availability on the iPhone. A search of the Google Play store yielded 645 unique applications and was narrowed to 634 based on relevance. Of note, 49 apps appeared in both app stores using the search terms. An aggregate 927 apps from the Apple iTunes and Google Play stores were then critically reviewed by the authors. Apps were sub-categorized based on intended audience, layperson or first responder, and sorted into one of five disaster response categories. Two apps were chosen for discussion from each of the five sub-categories. The highest quality apps were determined from each group based on relevance to emergency preparedness and disaster response, rating, and number of reviews.Conclusion:After comparisons with the 2015 article, many new apps have been developed and previously described apps have been updated, highlighting that this is a constantly changing field deserving of continued analysis and research.
A narrative review exploring the professional practice training requirement of therapeutic radiographers undertaking effective remote/telephone review clinics in place of face-to-face radiographer-led review clinics during the COVID-19 pandemic
Authors: Andrews Gemma , Flood Terri , Shepherd Paul 
Published: December 2021

Abstract

Background and purpose:
The COVID-19 pandemic has led to the introduction of alternative on-treatment and post-treatment radiographer-led review clinics in an attempt to protect patients, staff and the public. Pre-COVID, patient reviews were routinely undertaken face-to-face, led by therapeutic review radiographers with advanced practice qualifications and skills in radiotherapy symptom management, triage, referral and support services. During the COVID-19 pandemic, an alternative option has been to follow-up in the form of telephone reviews to reduce face-to-face exposure whilst continuing to manage patient radiotherapy treatment-related toxicities. The aim of the narrative review is to explore the subject of telephone reviews and how therapeutic review radiographers might need to adapt communication skills so that they can continue to effectively assess and manage radiotherapy patient treatment reactions remotely.

Method and discussion:
A narrative review was conducted using the SCOPUS database and 28 publications were included from 2013 to 2021. The review highlights a paucity of literature exploring specific telephone training for radiographers and other allied healthcare professionals. Experiences within medical and nursing programmes demonstrate that development and integration of training in this area is critical in preparing for patient interaction via telephone.

Conclusion and implications for practice:
Multiple teaching modalities including simulation are ideal for teaching telephone-specific skills and content, demonstrating improvement in student knowledge, competence and confidence. Less is known regarding whether this knowledge translates to an improved patient experience. Enhancements in education and training, guided by the Health and Care Professions Council, may be warranted to ensure that patients continue to receive the optimal quality of care in a world where remote reviews are likely to become commonplace. Patient-reported outcome measures might be utilized for future training evaluations to ensure that effective patient care is being maintained.
Increasing River Alkalinity Slows Ocean Acidification in the Northern Gulf of Mexico
Authors: Gomez Fabian A. , Wanninkhof Rik , Barbero Leticia , Lee Sang‐Ki 
Published: December 2021

AbstractOcean acidification (OA) progression is affected by multiple factors, such as ocean warming, biological production, and river runoff. Here we used an ocean‐biogeochemical model to assess the impact of river runoff and climate variability on the spatiotemporal patterns of OA in the Gulf of Mexico (GoM) during 1981–2014. The model showed the expected pH and aragonite saturation state (ΩAr) decline, due to the increase in anthropogenic carbon, with trends close to values reported for the Subtropical North Atlantic. However, significant departures from the basin‐averaged pattern were obtained in part of the northern GoM shelf, where pH and ΩAr increased. Model sensitivity analyses showed that OA progression was counteracted by enhanced alkalinity from the Mississippi‐Atchafalaya River System. Our findings highlight that river alkalinity is a key driver of carbon system variability in river‐dominated ocean margins and emphasize the need to quantify riverine chemistry to properly assess acidification in coastal waters.
Stress and Strain Rate Evolution During the Finite Strain Deformation of a Weak Ferropericlase Grain by Diffusion Creep: Implications for Shear Localization in the Lower Mantle
Authors: Cho H. E. , Karato Shun‐ichiro 
Published: December 2021

AbstractWe investigate the finite deformation of a weak inclusion embedded in a strong matrix. The goal is to understand the possible causes for shear localization that would explain the presence of geochemical heterogeneity in the Earth's lower mantle. The weak phase in the lower mantle is ferropericlase (Fp), and the strong phase is bridgmanite (Br). We herein consider deformation by diffusion creep for which some supporting evidence is available. When an inclusion deforms by diffusion creep, deformation itself modifies its geometry and stress distribution. The modified stress distribution in turn leads to strain‐dependent rheological properties due to the changes in diffusion path length and the stress gradient that drives diffusion flux. We investigate the evolution of deformation of a weak inclusion (i.e., Fp‐like weak grain embedded in Br‐like strong matrix) using the Eshelby theory (for stress and strain rate fields) combined with a theory of diffusional mass transport caused by the gradient in the normal stress within the inclusion. We found that finite strain leads to a significant strain weakening under simple shear deformation but not under axial deformation. Since diffusion creep is thought to be a dominant mechanism of the lower mantle rheology, the results of the present study provide a basis for investigating the nature of shear localization and its important implication for the preservation of geochemical heterogeneity and the distribution of seismic anisotropy in the lower mantle.
RANSE Modeling of the Oscillatory Flow Over Two‐Dimensional Rigid Ripples
Authors: Sishah B. , Vittori G. 
Published: December 2021

AbstractThe oscillatory turbulent flow over two‐dimensional ripples is numerically simulated. Both the profile of the ripples and the values of the parameters used in the present study are typical of vortex ripples at the bottom of sea waves. The flow is computed numerically by using a RANSE approach. The results show that, as the ratio between the fluid excursion and the ripple wavelength is increased, the vortex shed on one side of the ripple crest is no longer the mirror image of the vortex shed on the other side and the dynamics of the vortex structures becomes quite complex. Moreover, the formation of steady recirculating cells, which might distort the profile of ripples in an erodible bed, is observed. A horizontal steady streaming is also generated, whose positive/negative direction depends on the values of the parameters.
Longitudinal dietary trajectories from preconception to mid-childhood in women and children in the Southampton Women’s Survey and their relation to offspring adiposity: a group-based trajectory modelling approach
Authors: Dalrymple Kathryn V. , Vogel Christina , Godfrey Keith M. , Baird Janis , Harvey Nicholas C. , Hanson Mark A. , Cooper Cyrus , Inskip Hazel M. , Crozier Sarah R. 
Published: December 2021

AbstractBackgroundRates of childhood obesity are increasing globally, with poor dietary quality an important contributory factor. Evaluation of longitudinal diet quality across early life could identify timepoints and subgroups for nutritional interventions as part of effective public health strategies.ObjectiveThis research aimed to: (1) define latent classes of mother-offspring diet quality trajectories from pre-pregnancy to child age 8–9 years, (2) identify early life factors associated with these trajectories, and (3) describe the association between the trajectories and childhood adiposity outcomes.DesignDietary data from 2963 UK Southampton Women’s Survey mother-offspring dyads were analysed using group-based trajectory modelling of a diet quality index (DQI). Maternal diet was assessed pre-pregnancy and at 11- and 34-weeks’ gestation, and offspring diet at ages 6 and 12 months, 3, 6-7- and 8–9-years using interviewer-administered food frequency questionnaires. At each timepoint, a standardised DQI was derived using principal component analysis. Adiposity age 8–9 years was assessed using dual-energy X-ray absorptiometry (DXA) and BMIz-scores.ResultsA five-trajectory group model was identified as optimal. The diet quality trajectories were characterised as stable, horizontal lines and were categorised as poor (n = 142), poor-medium (n = 667), medium (n = 1146), medium-better (n = 818) and best (n = 163). A poorer dietary trajectory was associated with higher maternal pre-pregnancy BMI, smoking, multiparity, lower maternal age and lower educational attainment. Using linear regression adjusted for confounders, a 1-category decrease in the dietary trajectory was associated with higher DXA percentage body fat (0.08 SD (95% confidence interval 0.01, 0.15) and BMIz-score (0.08 SD (0.00, 0.16) in the 1216 children followed up at age 8–9 years.ConclusionMother-offspring dietary trajectories are stable across early life, with poorer diet quality associated with maternal socio-demographic and other factors and childhood adiposity. The preconception period may be an important window to promote positive maternal dietary changes in order to improve childhood outcomes.
Engineered HaloTag variants for fluorescence lifetime multiplexing
Authors: Frei Michelle S. , Tarnawski Miroslaw , Roberti M. Julia , Koch Birgit , Hiblot Julien , Johnsson Kai 
Published: December 2021

AbstractSelf-labeling protein tags such as HaloTag are powerful tools that can label fusion proteins with synthetic fluorophores for use in fluorescence microscopy. Here we introduce HaloTag variants with either increased or decreased brightness and fluorescence lifetime compared with HaloTag7 when labeled with rhodamines. Combining these HaloTag variants enabled live-cell fluorescence lifetime multiplexing of three cellular targets in one spectral channel using a single fluorophore and the generation of a fluorescence lifetime-based biosensor. Additionally, the brightest HaloTag variant showed up to 40% higher brightness in live-cell imaging applications.
Language distance modulates cognitive control in bilinguals
Authors: Radman Narges , Jost Lea , Dorood Setareh , Mancini Christian , Annoni Jean-Marie 
Published: December 2021

AbstractLinguistic processes in the bilingual brain are partially shared across languages, and the degree of neural overlap between the languages is influenced by several factors, including the age of acquisition, relative language proficiency, and immersion. There is limited evidence on the role of linguistic distance on the performance of the language control as well as domain-general cognitive control systems. The present study aims at exploring whether being bilingual in close and distant language pairs (CLP and DLP) influences language control and domain-general cognitive processes. We recruited two groups of DLP (Persian–English) and CLP (French–English) bilinguals. Subjects performed language nonswitching and switching picture-naming tasks and a nonlinguistic switching task while EEG data were recorded. Behaviorally, CLP bilinguals showed a lower cognitive cost than DLP bilinguals, reflected in faster reaction times both in language switching (compared to nonswitching) and nonlinguistic switching. ERPs showed differential involvement of cognitive control regions between the CLP and DLP groups during linguistic switching vs. nonswitching at 450 to 515 ms poststimulus presentation. Moreover, there was a difference between CLP and DLP groups from 40 to 150 ms in the nonlinguistic task. Our electrophysiological results confirm a stronger involvement of language control and domain-general cognitive control regions in CLP bilinguals.
Water deficit changes the relationships between epidemiological traits of Cauliflower mosaic virus across diverse Arabidopsis thaliana accessions
Authors: Bergès Sandy E. , Vile Denis , Yvon Michel , Masclef Diane , Dauzat Myriam , van Munster Manuella 
Published: December 2021

AbstractChanges in plant abiotic environments may alter plant virus epidemiological traits, but how such changes actually affect their quantitative relationships is poorly understood. Here, we investigated the effects of water deficit on Cauliflower mosaic virus (CaMV) traits (virulence, accumulation, and vectored-transmission rate) in 24 natural Arabidopsis thaliana accessions grown under strictly controlled environmental conditions. CaMV virulence increased significantly in response to water deficit during vegetative growth in all A. thaliana accessions, while viral transmission by aphids and within-host accumulation were significantly altered in only a few. Under well-watered conditions, CaMV accumulation was correlated positively with CaMV transmission by aphids, while under water deficit, this relationship was reversed. Hence, under water deficit, high CaMV accumulation did not predispose to increased horizontal transmission. No other significant relationship between viral traits could be detected. Across accessions, significant relationships between climate at collection sites and viral traits were detected but require further investigation. Interactions between epidemiological traits and their alteration under abiotic stresses must be accounted for when modelling plant virus epidemiology under scenarios of climate change.
Expression of immune-related genes as prognostic biomarkers for the assessment of osteosarcoma clinical outcomes
Authors: Guo Junjie , Li Xiaoyang , Shen Shen , Wu Xuejian 
Published: December 2021

AbstractCancer immunotherapy is a promising therapeutic approach, but the prognostic value of immune-related genes in osteosarcoma (OS) is unknown. Here, Target-OS RNA-seq data were analyzed to detect differentially expressed genes (DEGs) between OS subgroups, followed by functional enrichment analysis. Cox proportional risk regression was performed for each immune-related gene, and a risk score model to predict the prognosis of patients with OS was constructed. The risk scores were calculated using the risk signature to divide the training set into high-risk and low-risk groups, and validation was performed with GSE21257. We identified two immune-associated clusters, C1 and C2. C1 was closely related to immunity, and the immune score was significantly higher in C1 than in C2. Furthermore, we validated 6 immune cell hub genes related to the prognosis of OS: CD8A, KIR2DL1, CD79A, APBB1IP, GAL, and PLD3. Survival analysis revealed that the prognosis of the high-risk group was significantly worse than that of the low-risk group. We also explored whether the 6-gene prognostic risk model was effective for survival prediction. In conclusion, the constructed a risk score model based on immune-related genes and the survival of patients with OS could be a potential tool for targeted therapy.
Cycloaddition of N-sulfonyl and N-sulfamoyl azides with alkynes in aqueous media for the selective synthesis of 1,2,3-triazoles
Authors: Prasanth Thumpati , Chakraborti Gargi , Mandal Tirtha , Ravichandiran Velayutham , Dash Jyotirmayee 
Published: December 2021

The cycloaddition of N-sulfonyl and sulfamoylazides with terminal alkynes using a prolinamide ligand selectively provides 1,2,3-triazoles in aqueous media in the presence of CuI.
A high step‐up interleaved boost‐Cuk converter with integrated magnetic coupled inductors
Authors: Rong Desheng , Sun Xuanjin , Wang Ning 
Published: December 2021

AbstractThis paper proposes a high step‐up interleaved boost‐Cuk converter with integrated magnetic coupled inductor that is suitable for photovoltaic systems. By connecting the boost converter and the Cuk converter in parallel at the input terminal and the output terminal in series and integrating a coupled inductor voltage multiplier cell, the proposed converter achieves a higher voltage gain while retaining the continuous input and output current characteristics of the Cuk converter. The passive clamping branch is used to absorb the leakage inductance energy, which effectively suppresses the voltage spike generated by the switch parasitic capacitance and leakage inductance resonance and reduces the maximum voltage stress of the switch. The operation principle of the converter is analysed and the magnetic integration equivalent model and design criteria of the two coupled inductors are given. An array magnetic integrated structure is designed, which effectively reduces the DC bias inside the magnetic core. Finally, a 380 W experimental prototype is built to verify the theoretical analysis.
Automotive radar interference study for different radar waveform types
Authors: Kumbul Utku , Uysal Faruk , Vaucher Cicero S. , Yarovoy Alexander 
Published: December 2021

AbstractMutual interference between different radar waveforms used in automotive radar applications is studied. The existing interference analysis is extended to a generalised radar‐to‐radar interference equation that covers most of the common interference scenarios for automotive radar systems. The outcome of the generalised equation is demonstrated for a number of typical scenarios where radars with different continuously transmitting waveforms are involved. The proposed equation can be used to characterise the received interference and its features by analysing the instantaneous beat frequency of the victim radar. Moreover, an interference analysis of phase‐coded frequency‐modulated continuous waveforms is performed and demonstrated experimentally by using real‐time automotive radars for the first time in the literature. The experimental results corroborate the interference analysis of different waveforms and validate the proposed generalised interference equation under various conditions.
Implicit-explicit multistep formulations for finite element discretisations using continuous interior penalty
Authors: Burman Erik , Guzmán Johnny 
Published: December 2021

We consider a finite element method with symmetric stabilisation for the discretisation of the transient convection–diffusion equation. For the time-discretisation we consider either the second order backwards differentiation formula or the Crank–Nicolson method. Both the convection term and the associated stabilisation are treated explicitly using an extrapolated approximate solution. We prove stability of the method and the τ2 + hp+½ error estimates for the L2-norm under either the standard hyperbolic CFL condition, when piecewise affine (p = 1) approximation is used, or in the case of finite element approximation of order p ≥ 1, a stronger, so-called 4/3-CFL, i.e. τ ≤ Ch4/3. The theory is illustrated with some numerical examples.