bluuebunny/crossref_metadata_2025_split huggingface dataset:
Особенности циркуляции Torque teno вируса в цереброспинальной жидкости у пациентов с инфекционными поражениями центральной нервной системы
Authors: Иванова А.А. , Зенькова С.К. , Семёнов В.М. , Дмитраченко Т.И. , Егоров С.К. , Косова М.С. 
Published: December 2024

В течение всего периода своего существования Torque teno вирус (TTV) представляет большой интерес для исследователей всего мира. Роль TTV в развитии патологий различных органов и систем, несмотря на почти тридцатилетнюю историю известного существования этого вируса, не определена. Результаты исследований неоднозначны, что указывает на необходимость дальнейших изысканий. Целью работы явилось установление частоты обнаружения и уровня вирусной нагрузки TTV в цереброспинальной жидкости (ЦСЖ) пациентов с инфекционной патологией ЦНС. В исследование были включены 114 пациентов с симптомами функциональных нарушений ЦНС: 5 пациентов с бактериальными поражениями ЦНС, 44 пациента с вирусными поражениями ЦНС, 65 пациентов без изменений ликвора. Обнаружение ДНК TTV осуществляли методом ПЦР в режиме реального времени. ДНК TTV в ЦСЖ обнаружена у 28,9% обследованных пациентов, в том числе 100% пациентов с поражениями ЦНС бактериальной этиологии, 29,5% пациентов с вирусными менингитами/ менингоэнцефалитами, 23,1% пациентов без изменений в ЦСЖ. При бактериальных менингитах вирусная нагрузка TTV оказалась достоверно выше, чем у пациентов с серозными менингитами (p=0,013) и у пациентов без патологических изменений в ЦСЖ (p=0,0076). В процессе лечения при наличии эффекта от проводимой терапии уровень ДНК TTV снижался, что может косвенно указывать на возможность использования уровня вирусной нагрузки в качестве прогностического фактора течения инфекционного процесса в ЦНС.
Torque teno virus (TTV) has been of great interest to researchers all over the world throughout its existence. The role of TTV in the development of pathologies of various organs and systems, despite almost thirty years of known existence of this virus, has not been defined. The results of studies are ambiguous, which indicates the need for further research. The aim of this work was to establish the frequency of detection and level of TTV viral load in CSF of patients with infectious pathology of CNS. The study included 114 patients with symptoms of functional CNS disorders: 5 patients with bacterial CNS lesions, 44 patients with viral lesions, and 65 patients without changes in CSF. TTV DNA detection was performed by real-time PCR. TTV DNA in CSF was detected in 28.9% of the examined patients, including 100% of patients with CNS lesions of bacterial etiology, 29.5% of patients with viral meningitis/meningoencephalitis, and 23.1% of patients without changes in CSF. In bacterial meningitis viral load of TTV was significantly higher than in patients with serous meningitis (p=0.013) and in patients without pathological changes in CSF (p=0.0076). In the course of treatment, under the condition of the presence of the effect of therapy, the level of TTV DNA decreased, which may indirectly indicate the possibility of using the level of viral load as a prognostic factor of the course of the infectious process in the CNS.
Оценка показателей центральной гемодинамики и внешнего дыхания у пациентов после внебольничной коронавирусной пневмонии
Authors: Назаров Ф.Ю. , Ярмухамедова С.Х. 
Published: December 2024

В 2024 г. продолжается фиксация вспышек COVID-19, вызываемых вирусом SARS-CoV-2. Наряду с ростом числа пациентов все большее число из них продолжают описывать такие симптомы, как усталость, сердцебиение, снижение физической активности, одышка, боль в груди, нейрокогнитивные трудности, мышечные боли и слабость, депрессия, тревога и другие психические расстройства. Эти симптомы сохраняются в течение нескольких недель после того, как острая фаза вирусной инфекции прошла. Затяжной синдром COVID-19 уникален по сравнению с постострыми синдромами, развившимися после других тяжелых инфекций, тем, что он был описан даже у пациентов, перенесших легкие и средние формы инфекции и не требовавших госпитализации в отделение интенсивной терапии. Появилась гипотеза, что хроническая виремия может быть вызвана неадекватным или отсутствующим ответом антител, воспалением и иммунологическими реакциями, декондиционированием, вызванным посттравматическим стрессом, или даже рецидивом и/или повторным заражением вирусом SARS-CoV-2. Эти условия могут повысить риск повреждения и воспаления миокарда, что впоследствии способно привести к дисфункции левого желудочка сердца.
In 2024, the detection of COVID-19 outbreaks caused by the SARS-CoV-2 virus continues. Along with the growing number of patients, an increasing number of them continue to describe symptoms such as fatigue, palpitations, decreased physical activity, shortness of breath, chest pain, neurocognitive difficulties, muscle pain and weakness, depression, anxiety and other mental disorders. These symptoms persist for several weeks after the acute phase of the viral infection has passed. The prolonged COVID-19 syndrome is unique compared to the post-acute syndromes that developed after other severe infections, in that it was described even in patients who had suffered mild and moderate forms of infection and did not require hospitalization in the intensive care unit. It has been hypothesized that chronic viremia may be caused by an inadequate or absent antibody response, inflammation and immunological reactions, deconditioning caused by post- traumatic stress, or even relapse and/or re-infection with the SARS-CoV-2 virus. These conditions can increase the risk of myocardial damage and inflammation, which can subsequently lead to dysfunction of the left ventricle of the heart.
Deforestasi Dan Tanggung Jawab Manusia Dalam Al-Qur’an (Studi Tafsir Hidayatul Insan Karya Abu Yahya Marwan Bin Musa)
Authors: Yusman Dinda Febriana , Ghozali Abdul Malik , Hendro Beko 
Published: December 2024

Artikel ini bertujuan untuk menganalisis pandangan Abu Yahya Marwan bin Musa tentang deforestasi dan tanggung jawab manusia terhadap lingkungan di dalam Al-Qur’an. Penelitian ini disusun menggunakan metode kualitatif dengan teknik penelitian kepustakaan (library research) yaitu dengan mengumpulkan berbagai referensi yang berkaitan dengan masalah penelitian, kemudian dalam menganalisis data peneliti menggunakan pendekatan analisis isi (conten analysis). Hasil penelitian ini antara lain: Pertama, Abu Yahya berpendapat bahwa deforestasi sebagai bentuk kerusakan lingkungan merupakan tindakan maksiat yang merusak bumi. Kerusakan lingkungan ini disebabkan oleh lemahnya iman, serta perbuatan fasik dan maksiat. Kedua, Abu Yahya berpendapat bahwa manusia memiliki peran dan tanggung jawab sebagai hamba Allah untuk beribadah kepadaNya dan sebagai khalifah yang bertugas untuk mengelola dan memakmurkan bumi, serta memberlakukan perintahNya.
Interaksi Dan Resepsi Masyarakat Bondowoso Terhadap Al Qur’an
Authors: Ulum Khoirul , Roziqin Ahmad Khoirur 
Published: December 2024

Studi mengenai Living Qur’an merupakan studi al-Qur’an yang tidak hanya bertumpu pada eksistensi tekstualnya, melainkan studi tentang fenomena sosial yang lahir terkait dengan kehadiran al-Qur’an dalam wilayah geografi tertentu dan mungkin masa tertentu pula. Kajian living al-Qur’an semakin menarik seiring dengan meningkatnya kesadaran masyarakat Islam terhadap ajaran agamanya. Kita banyak menjumpai kegiatan-kegiatan keagamaan, baik di tempat-tempat tertentu seperti masjid maupun di media cetak dan elektronik. Penelitian ini mengangkat tema “Pembacaan dan Pemaknaan Al-Qur'an (Studi Masyarakat Bondowoso). Sebagai upaya dan aplikasi kajian living al-Qur’an. Lokasi yang menjadi focus kajian adalah di Kabupaten Bondowoso.
Kajian ini menggunakan metode penelitian kualitatif, yaitu penelitian kepustakaan (library research) dan penelitian lapangan (field research) sekaligus. Sumber utama penelitian ini adalah ayat-ayat al-Qur’an yang hidup dalam masyarakat berupa fenomena prilaku maupun respons lainnya sebagai pemaknaan terhadap ayat tersebut. Sedangkan sumber sekundernya dapat berupa literatur- literatur pendukung sumber primer. Berdasarkan kajian mengenai Interaksi dan Resepsi Masyarakat Bondowoso terhadap Al-Qur'an, maka terdapat beberapa kesimpulan bahwa interaksi dibagi menjadi dua moment, yaitu rutinan dan moment insidental menyesuaikan hajat (kebutuhan). Pelaksanaan tersebut terdiri dari berbagai bentuk dan model-model ritual pembacaan al-Qur’an meliputi: (1). Khataman al-Qur’an. (2). Yasinan. (3). Tahlilan. Sedangkan resepsi dari interaksi tersebut terdapat tiga makna. Diantaranya; sebagai kitab bacaan mulia, obat hati dan sarana perlindungan dari bahaya siksa di hari akhir. Tiga makna tersebut, tidak mesti berjalan secara bersamaan, dan terkadang mempunyai makna bersamaan sekaligus.
Kisah Khaulah Bint Ṡa’labah (Studi Qs. Al-Mujādalah (58): 1-4) Perspektif Maqāsid Al-Qur’ān Rasyīd Riḍā
Authors: Rohman Lailur , Rohmah Husnur 
Published: December 2024

Penelitian ini bertujuan untuk mengungkap Maqāsid Al-Qur’ān perspektif Rasyīd Riḍā. Karena luasnya penelitian, penulis mengambil sampel pada QS. al-Mujādalah (58): 1-4), spesifikasi tersebut dipakai penulis untuk menelisik Maqāsid Al-Qur’ān perspektif Rasyīd Riḍā. Penelitian ini merupakan penelitian pustaka dengan menggunakan metode tematik surah serta pendekatan Maqāsid Al-Qur’ān perspektif Rasyīd Riḍā. Ada dua rumusan masalah utama dalam penelitian ini, yakni: Bagaimana penafsiran QS. al-Mujādalah (58): 1-4, 2. Bagaimana pandangan Islam terhadap perempuan dalam konteks kesetaraan gender melalui kisah Khaulah bint Ṡa’labah perspektif maqasid Rasyīd Riḍā. Melalui penelitian ini, lanskap Maqāsid Al-Qur’ān perspektif Rasyīd Riḍā teruraikan. Hasil dari penelitian ini adalah pertama, penafsiran dari QS. al-Mujādalah (58): 1-4 adalah bahwasanya surah tersebut turun berdasarkan seorang perempuan yang bernama Khaulah yang merasa ditindas oleh suaminya yang kemudian dia mengajukan gugatan atas tindakan suaminya tersebut, kedua, Dalam kisah Khaulah bint Sa’labah diatas, Al-Qur’an tidak pernah menggambarkan seorang perempuan dalam bentuk fisiknya yang mana hal ini juga membuktikan betapa berharganya perempuan dalam Islam. Dan hal itu selaras dengan pemikiran maqasid Al-Qur’an perspektif Rasyid Ridha yang juga tentang bagaimana Al-Qur’an menyikapi seorang perempuan
Penyimpangan Seksual Dalam Al-Qur’an (Analisis Ayat-Ayat LGBT)
Authors: Wafi Asma Latifah 
Published: December 2024

Salah satu isu aktual dan kontroversial adalah munculnya kelompok lesbian, gay, biseksual, dan transgender (LGBT). Seiring dengan berkembangnya teknologi, banyak budaya Barat yang sedikit demi sedikit diterapkan oleh masyarakat Indonesia. Salah satu dari budaya Barat tersebut adalah normalisasi adanya LGBT. Sudah banyak terlihat di media sosial anak remaja di Indonesia secara terang-terangan mengakui bahwa dirinya menyukai terhadap sesama jenis dan menganggap bahwa orientasi seksual sesama jenis adalah sah. Sejarah telah membuktikan bahwa seks sesama jenis sudah ada sejak zaman dahulu dan telah terkisahkan dalam al-Quran tentang kisah kaum nabi Luth. Tujuan dibuatnya artikel ini guna mengetahui dampak yang ditimbulkan dari LGBT baik dari segi kesehatan, sosial, pendidikan dan keamanan. Metode yang digunakan dalam penelitian ini adalah metode kualitatif yang bersifat studi pustaka yang menggunakan buku-buku dan Literatur lainnya sebagai Literatur utama. Hasil dari penelitian ini adalah bahwa LGBT di Indonesia diklasifikasikan menjadi dua entitas yaitu mereka yang menutupi identitasnya dan membuka identitasnya secara terang-terangan.
Perspektif Al-Qur’an Tentang Tipologi Anak Dan Cara Menyikapinya
Authors: Mahmud Basri , Jamaluddin Jamaluddin , Mujahid Mujahid 
Published: December 2024

This research aims to uncover the meaning of "child" and its typology from the perspective of the Qur'an. This study is descriptive qualitative in nature and employs the thematic interpretation method. The data used consists of primary data in the form of Qur'anic verses and secondary data related to this topic. The data is processed through a series of steps including reduction, data presentation, and verification until a conclusion is reached. The research findings show that the terminology for "child" in the Qur'an appears in various forms. For instance, the word zurriyyah is mentioned 32 times, walad 62 times, ghulam 13 times, al-Sabiy 2 times, al-Tiflu 4 times, al-Bintu and its variants are mentioned 17 times, and ibn along with its derivatives appears 112 times. The word walad has a broader meaning as it encompasses all types of children, unlike the word ibn, which also means "child" but is specifically used to refer to a male child, while a female child is referred to as ibnah. The word ghulam focuses on a child who has reached maturity, al-sabiy refers to a child who has not yet reached puberty, while al-tifl refers to a child younger than one called al-Sabiy. As for the typology of children from the Qur'anic perspective, children can be an obstacle or an enemy if they prevent someone from doing good deeds. They are also described as ornaments of the world, meant to be a means for parents to perform righteous acts. Additionally, children are a test from Allah to examine how parents treat them. On the other hand, righteous children who are obedient to Allah and devoted to their parents bring comfort and peace to the heart.
Factors associated with death in patients with atrial fibrillation
Authors: Duvanovа S. P. , Khoroshavtseva L. V. , Gorbunova E. V. , Mamchur S. E. , Barbarash O. L. 
Published: December 2024

The aim of the study was to analyze the factors influencing the mortality prognosis for atrial fibrillation (AF) among the adult population of the Kuzbass region.Methods. 576 patients with AF were included in the study. During a three-year follow-up death was recorded in 54 (9.4%) patients. An analysis of factor s associated with mortality was carried out. Multiple logistic regression, Quasi-Newton measurement method, ROC analysis were used, the critical significance level was 0.05.Results. According to the conducted study data, a statistically significant increase in the chance of a fatal outcome was revealed in individuals with a history stroke (odds ratio (OR) 2.47 [1.06-5.75]), with a body mass index (BMI) equal to or higher than 32.4±6.8 kg/m2 (OR 1.07 [1.01-1.14]), with an increase in the ventricular rate (VR) of AF equal to or higher than 84.2±15.4 beats per minute (OR 1.02 [1.00-1.04]) and the risk of thromboembolic complications according to the CHA2DS2 VASc scale equal to or higher than 4.3±2.3 points (OR 1.12 [1.04-1.21]). A decrease in creatinine clearance (CC) according to Cockcroft-Gault was associated with a high risk of adverse outcome (OR 0.99 [0.98-1.00]). At the same time, the fact of irregular intake of anticoagulant therapy was associated with a high probability of death, but did not depend on which anticoagulant was prescribed.Conclusions. According to the results of a complex analysis it was revealed that patients with AF who have a history of stroke, high values of BMI, ventricular rate AF, CHA2DS2 VASc were more often having an unfavorable outcome.
Nonfluoroscopic catheter ablation of tachyarrhythmias in patients with antiarrhythmic devices
Authors: Kropotkin E. B. , Ivanitskiy E. A. , Gorton T. A. , Sakovich V. A. 
Published: December 2024

Aim. To assess safety and effectiveness of zero fluoro catheter ablation (CA) of tachyarrhythmias in patients with antiarrhythmic device.Methods. One hundred ninety-seven patients with implanted antiarrhythmic device and indication for catheter ablation of tachyarrhythmias were included in retrospective study. In control group of patients n=63 (mean age 65.5±11.9 years) all procedures were performed under fluoroscopic guidance. In a study group, n=134 (mean age 66.1±15.6 years) all procedures were performed without the use of fluoroscopy. To reconstruct 3D anatomy we used navigation systems: magnet and impedance. In some cases we used intracardiac ultrasound. In the first group there were 65% of patients with pacemakers, 4.8% patients with implantable cardioverters-defibrillators and 30.2% of patients had cardiac resynchronization systems. In second 70.1%, 12.7% and 17.2% respectively. In control group CA was performed within 24 hours after device implantation in 13 patients (20.6%), in study group - 23 (17.2%). In the rest cohort of patients mean period between device implantation and CA was 29.26±28 months - in control group, 38.8±39 months. Antiarrhythmic device programming was performed before and right after CA.Results. Interventional catheter procedure was performed in 98.4% of patients in control group and in 98.5% of patients in study group. Radiation exposure in control group was 0.24 mZv, in study group 0 mZv. There were no conversions from zero fluoroscopy procedure to X -ray controlled due to different reasons. In control (fluoroscopy controlled) group 8 hours after CA ventricle lead dislodgement was diagnosed. Antiarrhythmic device in this patient was implanted 6 days before CA. There were no lead dislodgements or cardiac pacing disorders in study group.Conclusion. Zero fluoroscopy CA of tachyarrhythmias in patients with antiarrhythmc device is as safe and effective as standard fluoroscopy controlled procedure.
Systolic, diastolic, and pulse blood pressure during premature ventricular contractions: relationship with characteristics of ectopic beats
Authors: Shubik Yu. V. , Korneev A. B. , Baturova M. A. , Morozov A. N. , Pivovarov V. V. , Zaytsev G. K. , Tikhonenko V. M. , Kormilytsin A. Yu. , Gordeeva M. V. , Berman M. V. 
Published: December 2024

The aim is to assess the relationship between systolic, diastolic, and pulse blood pressure (SBP, DBP, PBP) during ventricular extrasystoles (VE) and the individual characteristics of ectopic beats.Methods. The primary method of investigation was BP measurement for each heartbeat. Inclusion criteria were the presence of ≥10000 monomorphic VE per day. A total of 53 patients were included, either without structural heart changes or with minimal structural alterations. The mean of systolic, diastolic, and pulse BP (SBP, DBP, and PBP) during VE (SBP VE, DBP VE, PBP VE) and during post-extrasystolic sinus contraction (post VE SBP, post VE DBP, post VE PBP) were calculated for each patient as fractions of 1.0.Results. The QRS complex width in VE originating from the right ventricular outflow tract is greater than from the left ventricular outflow tract; fragmentation of the QRS complex is more commonly observed in these VE. Significant correlations were observed between SBP VE and mean coupling interval (CI), PBP VE and CI, and SBP VE and PBP VE, though not between DBP VE and CI. DBP VE was significantly associated with VE count and daily VE percentage, while PBP VE was associated with left ventricular ejection fraction. It has been shown that post-VE SBP and post VE DBP are lower, while post VE PBP is higher compared to the corresponding parameters of sinus beats preceding the VE. Significant relationships were found between post VE SBP and post VE PBP, the duration of the post-extrasystolic pause, and the presence of paired VE; between post VE DBP and post VE PBP, DBP VE, CI VE, the presence of non-sustained ventricular tachycardia, and daily VE percentage; between post VE PBP and DBP VE, the presence of non-sustained ventricular tachycardia, daily VE percentage, and post-extrasystolic pause duration. Post VE PBP was equally determined by values of post VE SBP and DBP.Conclusion. With the shortening of the VE coupling interval, its SBP decreases, while DBP increases slightly, which may determine its hemodynamic significance. In post-extrasystolic sinus beats, both SBP and DBP decrease.
Risk stratification for ventricular tachyarrhythmias after cardioverter-defibrillator implantation for primary prevention of sudden cardiac death: results of the IDEAL single-center prospective study
Authors: Ilov N. N. , Palnikova О. V. , Stompel D. R. , Zorin D. А. , Romantsov Е. I. , Terent’eva М. G. , Abdulkadyurov А. М. , Paskeev D. R. , Kulikova E. A. , Klimchuk D. О. , Petrova О. V. , Nechepurenko А. А. , Kolesnikov V. N. , Boytsov S. А. 
Published: December 2024

Aim. The aim of this study was to develop additional selection criteria for implanted cardioverter-defibrillator (ICD) implantation in the primary prevention of sudden cardiac death (SCD) based on the risk stratification for the development of sustained ventricular tachycardia (VT).Methods. The study included 451 patients with heart failure and reduced left ventricular ejection fraction (HFrEF) who were referred for ICD implantation for primary prevention of SCD. Participants underwent pre-implantation screening of clinical, instrumental, and laboratory parameters, followed by prospective observation for 24 months to record the first occurrence of sustained VT or justified ICD therapy. To achieve the study’s goal, training and test samples were formed.Results. The arrhythmic endpoint was recorded in 84 patients (26%) in the training group and in 35 patients (27%) in the test group. Univariate analysis identified 11 factors with the highest predictive potential (p<0.1) associated with the occurrence of the studied endpoint. These included clinical data: coronary artery disease, arterial hypertension, resting heart rate >80 bpm; electrocardiographic parameters: complete left bundle branch block according to Strauss criteria, P-wave duration (lead II) >120 ms, or the presence of atrial fibrillation (in the case of persistent form), index of cardiac electrophysiological balance (ICEB) >3.1; echocardiographic parameters: presence of eccentric left ventricular hypertrophy, global longitudinal strain ≥ minus 6%; laboratory markers: galectin-3 >12 ng/ml, sST-2 >35 ng/ml, NT-proBNP >2000 pg/ml. Based on the regression coefficients, points were assigned to each factor, and the sum of these points determined the value of a new proposed index - the arrhythmic risk index (ARI). ARI values >5 points predicted the two-year likelihood of VT in HFrEF patients with a sensitivity of 78.6% and specificity of 64.3% (AUC=0.788±0.028 with 95% confidence interval (CI): 0.732-0.843; p=0.0001). The application of ARI in the test group demonstrated good model performance in predicting two-year VT risk (AUC=0.652±0.053 with 95% CI: 0.547-0.757; p=0.008).Conclusion. Based on the obtained results, a predictive index was developed, allowing for personalized and timely risk assessment of VT in patients with HFrEF.