bluuebunny/crossref_metadata_2025_split huggingface dataset:
The NRW80+ study: conceptual background and study groups
Authors: Hansen Sylvia , Kaspar Roman , Wagner Michael , Woopen Christiane , Zank Susanne 
Published: September 2021

Abstract
Background
The study “Quality of life and well-being of the very old in North Rhine-Westphalia NRW80+” aims at giving a representative picture of the quality of life (QoL) in this population. Conceptually, QoL research has rarely considered the values of older individuals themselves and societal values, and their relevance for successful life conduct. Empirically, comparisons of different age groups over the age of 80 years are rare and hampered by quickly decreasing numbers of individuals in oldest age groups in the population of very old individuals.

Study design and theoretical framework
This paper describes the population of the NRW80+ study and different age groups of very old individuals with respect to biographical background. Furthermore, using the challenges and potentials model of QoL in very old age (CHAPO), key aspects of QoL in late life are discussed and the importance of normative stipulations of what constitutes a successful life conduct are highlighted. In the NRW80+ study older age groups (i.e., 85–89 years, 90+ years) were deliberately overrepresented in the survey sample to enable robust cross-group comparison. Individuals willing to participate in the study but unable to participate in the interview themselves for health reasons were included by means of proxy interviews.
The total sample included 1863 individuals and 176 individuals were represented by proxy interviews. Pronounced differences were observed between age groups 80–84 years (born 1933–1937, N = 1012), 85–89 years (born 1928–1932, N = 573), and 90 years or older (*born before 1927, N = 278) with respect to education, employment and the timing of major life events (e.g., childbirth).

Conclusion
Different life courses and resulting living conditions should be considered when discussing QoL disparities in very old age.
Financial burden and impact of atopic dermatitis out-of-pocket healthcare expenses among black individuals in the United States
Authors: Chovatiya Raj , Begolka Wendy Smith , Thibau Isabelle J. , Silverberg Jonathan I. 
Published: September 2021

AbstractBlack race is associated with increased atopic dermatitis (AD) severity and healthcare resource utilization. However, the burden of out-of-pocket (OOP) expenses among black individuals with AD is not well understood. We sought to characterize the categories and impact of OOP healthcare expenses associated with AD management among black individuals. A 25-question voluntary online survey was administered to National Eczema Association members (N = 113,502). Inclusion criteria (US residents age ≥ 18 years; self-report of AD or primary caregivers of individuals with AD) was met by 77.3% (1118/1447) of respondents. Black individuals with AD were younger, had lower household income, Medicaid, urban residence, poor AD control and frequent skin infections (P ≤ 0.02). Blacks vs. non-blacks reported more OOP costs for prescription medications covered (74.2% vs. 63.6%, P = 0.04) and not covered (65.1% vs. 46.5%, P = 0.0004) by insurance, emergency room visits (22.1% vs. 11.8%, P = 0.005), and outpatient laboratory testing (33.3% vs. 21.8%, P = 0.01). Black race was associated with increased household financial impact from OOP expenses (P = 0.0009), and predictors of financial impact included minimally controlled AD (adjusted OR [95% CI] 13.88 [1.63–117.96], P = 0.02), systemic therapy (4.34 [1.63–11.54], 0.003), > $200 monthly OOP expenses (14.28 [3.42–59.60], P = 0.0003), and Medicaid (4.02 [1.15–14.07], P = 0.03). Blacks with Medicaid had higher odds of harmful financial impact (3.32 [1.77–6.24], P = 0.0002) than those of black race (1.81 [1.04–3.15], P = 0.04) or with Medicaid (1.39 [1.02–1.88], P = 0.04) alone. Black race is associated with increased OOP costs for AD and significant household financial impact. Targeted interventions are needed to address financial disparities in AD.
Age-dependent gene expression of Calliphora vicina pupae (Diptera: Calliphoridae) at constant and fluctuating temperatures
Authors: Hartmann K. , Herrmann E. , Amendt J. , Verhoff M. A. , Zehner R. 
Published: September 2021

AbstractEstimating the age of the developmental stages of the blow fly Calliphora vicina (Diptera: Calliphoridae) is of forensic relevance for the determination of the minimum post-mortem interval (PMImin). Fly eggs and larvae can be aged using anatomical and morphological characters and their modification during development. However, such methods can only hardly be applied for aging fly pupae. Previous study described age estimation of C. vicina pupae using gene expression, but just when reared at constant temperatures, but fluctuating temperatures represent a more realistic scenario at a crime scene. Therefore, age-dependent gene expression of C. vicina pupae were compared at 3 fluctuating and 3 constant temperatures, the latter representing the mean values of the fluctuating profiles. The chosen marker genes showed uniform expression patterns during metamorphosis of C. vicina pupae bred at different temperature conditions (constant or fluctuating) but the same mean temperature (e.g. constant 10 °C vs. fluctuating 5–15 °C). We present an R-based statistical tool, which enables estimation of the age of the examined pupa based on the analysed gene expression data.
Can Tanzania’s adaptation measures prevent future maize yield decline? A simulation study from Singida region
Authors: Volk Johanna , Gornott Christoph , Sieber Stefan , Lana Marcos Alberto 
Published: September 2021

AbstractCereal crop production in sub-Saharan Africa has not achieved the much-needed increase in yields to foster economic development and food security. Maize yields in the region’s semi-arid agroecosystems are constrained by highly variable rainfall, which may be worsened by climate change. Thus, the Tanzanian government has prioritized agriculture as an adaptation sector in its intended nationally determined contribution, and crop management adjustments as a key investment area in its Agricultural Sector Development Programme. In this study, we investigated how future changes in maize yields under different climate scenarios can be countered by regional adjusted crop management and cultivar adaptation strategies. A crop model was used to simulate maize yields in the Singida region of Tanzania for the baseline period 1980–2012 and under three future climate projections for 2020–2060 and 2061–2099. Adaptation strategies to improve yields were full irrigation, deficit irrigation, mulch and nitrogen addition and another cultivar. According to our model results, increase in temperature is the main driver of future maize yield decline. Increased respiration and phenological development were associated with lower maize yields of 16% in 2020–2060 and 20% in 2061–2099 compared to the 1980–2012 baseline. Surprisingly, none of the management strategies significantly improved yields; however, a different maize variety that was tested as an alternative coping strategy performed better. This study suggests that investment in accessibility of improved varieties and investigation of maize traits that have the potential to perform well in a warmer future are better suited for sustaining maize production in the semi-arid region than adjustments in crop management.
Climate risk and agricultural technology adaption: evidence from rice farmers in the Ayeyarwady River delta of Myanmar
Authors: Muraoka Rie , Furuya Jun , Hirano Akira , Sakurai Takeshi 
Published: September 2021

AbstractCrop income can be raised in two ways: one way is to increase crop productivity and the other is to grow high-value crops that could be sold at high prices in the market. This study evaluated the adoption determinants of high-yielding varieties (HYVs) and high-value varieties (HVVs) of rice and their associations on crop income using data collected in coastal areas of the Ayeyarwady River delta, which is prone to climate shocks such as saltwater intrusion and cyclones. We used cross-sectional data on 298 rice-producing households and 393 rice plots to conduct multinomial logit estimates, which revealed that the heights of the plots, and past exposure to saltwater intrusion negatively affected the adoption of HVVs. Our estimates also suggest that while the adoption of HYVs is not associated with high rice yield, income, or profit, HVV adoption is associated with high income and profit.
Trigger poverty and reduplicative identity in Lakota
Authors: Paschen Ludger 
Published: September 2021

AbstractThis paper offers a phonological account of various ways in which reduplication interacts with independent processes in Lakota: transparent application in the case of cluster simplification, overapplication in the case of palatalization, and underapplication in the case of vowel mutation. I argue that all three patterns follow from phonological optimization rather than morpheme-specific constraints on the reduplicant or on other morphemes, and that the co-existence of divergent patterns is compatible with such a phonological analysis. Local application is the default pattern, while overapplication receives a cyclic explanation. For underapplication, which is the most recalcitrant pattern in Lakota, I offer an account in terms of Trigger Poverty, a concept which denotes an imbalance between the number of triggers and the number of potential targets created by copying. Trigger Poverty is likely to be a more general abstract source of underapplication beyond Lakota. This paper thus contributes to the discussion of modularity in phonology by presenting evidence that identity effects in reduplication can be epiphenomenal.
Social Integration of Second Generation Students in the Italian School System
Authors: Giovinazzi Francesco , Cocchi Daniela 
Published: September 2021

AbstractCultural divides and prejudice complicate the processes of integration and acculturation of migrant families living in a foreign country. Evaluating the impact of such phenomenon can be crucial for social stability and policy making. In this context, the education system has a leading role in fostering and attaining social integration, in particular when it comes to younger sections of the migrant population. In this work, we propose a method for the construction of a quantitative indicator capturing social integration of second generation students in the Italian school system according to areas defined by nationality of the students and administrative region in which they attend school. The indicator, based on survey data, is estimated by means of a 2-step methodology. In the first step, we choose an individual qualitative variable capturing social integration at the unit level, and we compute a first direct estimate of the indicator as the proportion of highly integrated students in each area. Such variable is isolated following alternatively a proxy variable approach or a latent variable model approach. In the second step, we make use of two alternative small area models to improve the estimates, dealing with missing values, low sample size and high variability in smaller domains. At the end, the 2-step methodology results in 4 alternative versions of a synthetic indicator of social integration, that can be used to rank nationalities and administrative regions.
Potential of Gold Nanoparticles for Noninvasive Imaging and Therapy for Vascular Inflammation
Authors: Kosuge Hisanori , Nakamura Maki , Oyane Ayako , Tajiri Kazuko , Murakoshi Nobuyuki , Sakai Satoshi , Sato Akira , Taninaka Atsushi , Chikamori Taishiro , Shigekawa Hidemi , Aonuma Kazutaka 
Published: September 2021

Abstract
Purpose
Macrophages contribute to the progression of vascular inflammation, making them useful targets for imaging and treatment of vascular diseases. Gold nanoparticles (GNPs) are useful as computed tomography (CT) contrast agents and light absorbers in photothermal therapy. In this study, we aimed to assess the viability of macrophages incubated with GNPs after near-infrared (NIR) laser light exposure and to evaluate the utility of intravenously injected GNPs for in vivo imaging of vascular inflammation in mice using micro-CT.

Procedures
Mouse macrophage cells (RAW 264.7) were incubated with GNPs and assessed for GNP cellular uptake and cell viability before and after exposure to NIR laser light. For in vivo imaging, macrophage-rich atherosclerotic lesions were induced by carotid ligation in hyperlipidemic and diabetic FVB mice (n = 9). Abdominal aortic aneurysms (AAAs) were created by angiotensin II infusion in ApoE-deficient mice (n = 9). These mice were scanned with a micro-CT imaging system before and after the intravenous injection of GNPs.

Results
The CT attenuation values of macrophages incubated with GNPs were significantly higher than those of cells incubated without GNPs (p < 0.04). Macrophages incubated with and without GNPs showed similar viability. The viability of macrophages incubated with GNPs (100 μg/ml or 200 μg/ml) was decreased by high-intensity NIR laser exposure but not by low-intensity NIR laser exposure. In vivo CT images showed higher CT attenuation values in diseased carotid arteries than in non-diseased contralateral arteries, although the difference was not statistically significant. The CT attenuation values of the perivascular area in AAAs of mice injected with GNPs were significantly higher than those of mice without injection (p = 0.0001).

Conclusions
Macrophages with GNPs had reduced viability upon NIR laser exposure. GNPs intravenously injected into mice accumulated in sites of vascular inflammation, allowing detection of carotid atherosclerosis and AAAs in CT imaging. Thus, GNPs have potential as multifunctional biologically compatible particles for the detection and therapy of vascular inflammation.
Validation and Psychometric Evaluation of the COVID-19 Risk Perception Scale (CoRP): a New Brief Scale to Measure Individuals’ Risk Perception
Authors: Capone Vincenza , Donizzetti Anna Rosa , Park Miriam Sang-Ah 
Published: September 2021

AbstractThe aim of the work was to develop and validate the COVID-19 Risk Perception Scale (CoRP), a brief self-report questionnaire for individuals’ perceptions of risk in the COVID-19 pandemic. Two studies were conducted in order to evaluate the new scale’s psychometric properties. Study 1 included 269 Italian participants (77.3% female) to initially test the scale’s structure and construct validity. Study 2 involved 1061 (76.2% female) Italians aged 18 to 80 years old and examined the structure of the scale, construct validity, and age invariance. Exploratory and Confirmatory factor analyses confirmed the one-factor solution, and the structure of the scale was found to be invariant across age groups. The scale also demonstrated a high internal reliability. The CoRP correlated positively with the fear of COVID-19 scale, and low with the Impact of Event and distressing phenomena as measured by GHQ. The present work thus affirms that the CoRP is a valid instrument for measuring individuals’ risk perception of COVID-19.
Evolution of the Non-metallic Inclusions Influenced by Slag-Metal Reactions in Ti-Containing Ferritic Stainless Steel
Authors: Wang Yong , Cho Jin-Hyung , Jeong Tae-Su , Karasev Andrey , Mu Wangzhong , Park Joo Hyun , Jönsson Pär G. 
Published: September 2021

Abstract
Laboratory experiment and thermodynamic calculation for the Ti-containing 24 mass pct Cr ferritic stainless steel with a CaO-SiO2-Al2O3-MgO system slag were performed to investigate the effect of slag addition on the inclusion characteristics in molten steel. The morphology, composition, and size evolution of inclusions in steel samples were analyzed in three-dimensional by the electrolytic extraction method and in two-dimensional by the automatic analysis method. The results showed that the Ti content significantly decreased after the slag addition. However, the change of the Si content showed an opposite tendency. The decrease of the Ti content in steel was due to the reduction of SiO2 and Al2O3 in the slag by dissolved Ti in steel. An increase of the TiO2 content in the slag can decrease the Ti loss in steel based on the slag-steel kinetic analysis. The total O content in the steel melt decreased from 62 to 26 ppm, and the steel cleanliness was improved, since the number density of inclusions decreased after the slag refining. The results of a kinetic analysis showed that the rate-determining step of the oxidation of Ti in the steel and the reduction of SiO2 in the slag were the mass transfer on the slag side. In addition, high Ti2O3-containing inclusions were found to be transformed to Cr2O3-Ti2O3-Al2O3 and Cr2O3-Ti2O3-SiO2 system inclusions after the slag addition. The Al2O3 contents in inclusions increased while the Ti2O3 contents decreased with time. However, there were some amount of high melting point inclusions with high Al2O3 content, which were not what we expected. When plotted on logarcxithmic scales, the mole ratio

$$X_{{{\text{Al}}_{2} {\text{O}}_{3} }} /(X_{{{\text{Ti}}_2 {\text{O}}_{3} }} \cdot X_{{{\text{Cr}}_{2} {\text{O}}_{3} }} )$$

X

Al
2

O
3

/

(

X

Ti
2

O
3

·

X

Cr
2

O
3

)

values of the inclusions were expressed as a linear function of the

$$a_{\text{Al}}^{2} /(a_{Ti}^{2} \cdot a_{\text{Cr}}^{2} \cdot a_{\text{O}}^{3} )$$

a

Al

2

/

(

a

Ti

2

·

a

Cr

2

·

a

O

3

)

values of the steel melts with a slope of unity, which was theoretically expected.
Current Treatment Options for Patients with Myotonic Dystrophy Type 2
Authors: Montagnese Federica 
Published: September 2021

Abstract
Purpose of the review
Myotonic dystrophy types 1 and 2 are frequent forms of muscular dystrophies in adulthood. Their clinical differences need to be taken into account for the most appropriate treatment of patients. The aim of this article is to provide an overview on the current and upcoming therapeutic options for patients with myotonic dystrophy type 2 (DM2).

Recent findings
At the moment, no disease-modifying therapies are available for DM2; next-generation therapies may however be available in the near future. In the meanwhile, the symptomatic management of patients has greatly improved, thank to the production of consensus-based standards of care and the growing evidence of efficacy of anti-myotonic drugs, promising employment of cannabinoids for symptom’s relief, regular monitoring, and early detection of treatable extra-muscular manifestations.

Summary
The treatment of DM2 is currently symptomatic and relies on the coordinated intervention of a multidisciplinary team. It remains to be determined whether upcoming causal therapies for myotonic dystrophy type 1 will be applicable also in DM2.
The Routine Follow-up Head CT: Is it Still a Necessary Step in the Thrombolysis Pathway?
Authors: Llinas Edward J. , Max Alexandra , Khan Sheena , Marsh Elisabeth B. 
Published: September 2021

AbstractBackgroundThe 24-h head computed tomography (CT) scan following intravenous tissue plasminogen activator or mechanical thrombectomy (MT) is currently part of most acute stroke protocols. However, as evidence emerges regarding who is at highest risk for treatment complications, the utility of routine neuroimaging for all patients has become less clear.MethodsFour hundred seventy-five patients presenting with acute ischemic stroke to Johns Hopkins Bayview Medical Center between 2004 and 2018 and treated with intravenous tissue plasminogen activator and/or MT were evaluated. Neuroimaging performed during the first 48 h of hospitalization was reviewed for edema, hemorrhagic transformation (HT), or other findings altering management. Early imaging (< 24 h), performed for neurologic deterioration, was compared with imaging performed per protocol (24 ± 6 h). Factors predictive of radiographically and clinically significant findings on per-protocol imaging were determined.ResultsOne hundred fifty-three patients (32%) underwent early imaging. These patients generally had more severe strokes. HT was found in 15% of cases. For the remaining patients (n = 322), imaging at 24 h impacted acute management for only 24 patients: resulting in emergent hemicraniectomy in 1 (0.3%) and leading to additional imaging to monitor asymptomatic HT or edema in 23 (7.1%). Advanced age, higher stroke severity, MT, and atrial fibrillation were associated with significant findings on the 24-h CT scan. Only 2 of the 24 patients had an initial National Institutes of Health Stroke Scale score of < 7.ConclusionsThe 24-h head CT scan does not change management for most patients, particularly those with low National Institutes of Health Stroke Scale scores who do not undergo MT. Consideration should be given to removing routine follow-up imaging from postthrombolysis protocols in favor of an examination-based approach.
Thinking with the Rain. The Trajectory of a Metaphor in Vygotsky’s Theoretical Development
Authors: Zittoun Tania 
Published: September 2021

AbstractVygotsky’s Notebooks edited by Zavershneva and Van der Veer (2018) give us a unique access to the inner-dialogue in which Vygotsky engaged while he was developing his theoretical work. In this paper, I propose to follow as “fil rouge” the semantic field associated to water, rain and clouds, and that will culminate as a “meteorological metaphor” through the Notebooks. Following the trajectory of this metaphor enables me to retrace the development of Vygotsky’s ideas about the dynamics uniting the planes of thinking and action, reality and inner life, affects and thinking. Doing so, I hope both to reflect on the role of a metaphor in the theoretical development of Vygotsky’s writings, and to highlight the potential and limits of his last series of theoretical explorations, which may inspire future work.
Mediating Knowledge Co-Production for Inclusive Governance and Delivery of Food, Water and Energy Services in African Cities
Authors: Sesan Temilade , Sanfo Safietou , Sikhwivhilu Keneiloe , Dakyaga Francis , Aziz Fati , Yirenya-Tawiah Dzidzo , Badu Mercy , Derbile Emmanuel , Ojoyi Mercy , Ibrahim Boubacar , Adamou Rabani 
Published: September 2021

AbstractRising rates of urbanisation in Africa, without attendant improvements in critical infrastructure, have occasioned gaps in the provision of basic services in cities across the continent. Different systems and scales of service delivery — decentralised and centralised, public and private — coexist and often compete in urban spaces but rarely connect in ways that ensure the needs of the poorest are met. Our paper interrogates the value of transdisciplinary research for bringing actors in these systems together to co-produce knowledge for inclusive and sustainable outcomes. Drawing on empirical data from two complementary projects in four African cities, we demonstrate the possibilities for facilitating this kind of knowledge co-production among system actors in the food, water and energy domains. We show, through a comparative approach, elements of the co-production process that enable more responsive engagement by traditionally detached policy actors. From our findings, we generate a framework that local researchers serving as ‘knowledge intermediaries’ can use to stimulate research-policy-society interactions aimed at fostering sustainable and inclusive service delivery across Africa. By synthesising the findings from local case studies into a widely applicable framework, our analysis informs both the theory and practice of transdisciplinary sustainability research in the African context where the imperative to bridge gaps in methodological innovation and service delivery is high.