bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indebted Demand
Authors: Mian Atif , Straub Ludwig , Sufi Amir 
Published: February 2021

Abstract
We propose a theory of indebted demand, capturing the idea that large debt burdens lower aggregate demand, and thus the natural rate of interest. At the core of the theory is the simple yet underappreciated observation that borrowers and savers differ in their marginal propensities to save out of permanent income. Embedding this insight in a two-agent perpetual-youth model, we find that recent trends in income inequality and financial deregulation lead to indebted household demand, pushing down the natural rate of interest. Moreover, popular expansionary policies—such as accommodative monetary policy—generate a debt-financed short-run boom at the expense of indebted demand in the future. When demand is sufficiently indebted, the economy gets stuck in a debt-driven liquidity trap, or debt trap. Escaping a debt trap requires consideration of less conventional macroeconomic policies, such as those focused on redistribution or those reducing the structural sources of high inequality.
On Sums Of Coefficients Of Maass Forms For SL(3, ℤ)
Authors: Zhai Wenguang 
Published: February 2021

Abstract
Let f be a Maass form for $SL(3,{\mathbb{Z}})$ with coefficients Af(m, n). The aim of this paper is to study the asymptotic behaviour of the sum $\sum_{m\leqslant x,n\leqslant y}|A_f(m,n)|^2$ and some other related sums.
Ultrasonography in the diagnosis and follow-up of giant cell arteritis
Authors: Coath Fiona L , Mukhtyar Chetan 
Published: February 2021

Abstract
Colour Doppler ultrasonography is the first measure to allow objective bedside assessment of GCA. This article discusses the evidence using the OMERACT filter. Consensus definitions for ultrasonographic changes were agreed upon by a Delphi process, with the ‘halo’ and ‘compression’ signs being characteristic. The halo is sensitive to change, disappearing within 2–4 weeks of starting glucocorticoids. Ultrasonography has moderate convergent validity with temporal artery biopsy in a pooled analysis of 12 studies including 965 participants [κ = 0.44 (95% CI 0.38, 0.50)]. The interobserver and intra-observer reliabilities are good (κ = 0.6 and κ = 0.76–0.78, respectively) in live exercises and excellent when assessing acquired images and videos (κ = 0.83–0.87 and κ = 0.88, respectively). Discriminant validity has been tested against stroke and diabetes mellitus (κ=−0.16 for diabetes). Machine familiarity and adequate examination time improves performance. Ultrasonography in follow-up is not yet adequately defined. Some patients have persistent changes in the larger arteries but these do not necessarily imply treatment failure or predict relapses.
Becoming the King in the North: identification with fictional characters is associated with greater self–other neural overlap
Authors: Broom Timothy W , Chavez Robert S , Wagner Dylan D 
Published: February 2021

Abstract
During narrative experiences, identification with a fictional character can alter one’s attitudes and self-beliefs to be more similar to those of the character. The ventral medial prefrontal cortex (vMPFC) is a brain region that shows increased activity when introspecting about the self but also when thinking of close friends. Here, we test whether identification with fictional characters is associated with increased neural overlap between self and fictional others. Nineteen fans of the HBO series Game of Thrones performed trait evaluations for the self, 9 real-world friends and 9 fictional characters during functional neuroimaging. Overall, the participants showed a larger response in the vMPFC for self compared to friends and fictional others. However, among the participants higher in trait identification, we observed a greater neural overlap in the vMPFC between self and fictional characters. Moreover, the magnitude of this association was greater for the character that participants reported feeling closest to/liked the most as compared to those they felt least close to/liked the least. These results suggest that identification with fictional characters leads people to incorporate these characters into their self-concept: the greater the immersion into experiences of ‘becoming’ characters, the more accessing knowledge about characters resembles accessing knowledge about the self.
Varying combinations of Lactobacillus species: impact on laying hens’ performance, nitrogenous compounds in manure, serum profile, and uric acid in the liver
Authors: Naseem Sadia , Willits Neil , King Annie J 
Published: February 2021

Abstract
This study was conducted to evaluate the effects of various combinations of Lactobacillus species (L. rhamnosus, L. paracasei, and L. plantarum) on closely associated variables of production of laying hens, nitrogenous compounds in manure, the serum concentration of specific chemicals, and liver uric acid (UA) concentrations at peak lay. White Leghorns W-36 (32-week-old) were randomly assigned to five treatments for 8 weeks. Treatments were T1, the Control, a commercial feed; T2, the Control + L. paracasei + L. plantarum; T3, the Control + L. paracasei + L. rhamnosus; T4, the Control + L. plantarum + L. rhamnosus and T5, the Control + L. paracasei + L. plantarum + L. rhamnosus. Each bacterial species was included at 3.33 × 1011cfu/kg feed for a total of 6.66 x 1011 cfu/kg feed for T2–T4 and a total of 1.0 × 1012 cfu/kg feed for T5. Major effects among combinations of probiotics on production were not noted. The interaction of Probiotics by Week (Probiotics*Time) affected feed intake (P = 0.0007) and feed conversion ratio (FCR, P = 0.0049) due to fluctuation by week. Significant effects of time were also recorded for a gradual increase in body weight (BW, P = 0.0007); lowest and greatest feed intake at weeks 2 and 7, respectively (P &lt; 0.0001); an increase in egg production (P = 0.0007) and maximum FCR at week 7 (P &lt; 0.0001). Ammonia (NH3) concentration, ammonium nitrogen (NH4–N), total Kjeldahl nitrogen (TKN), and total nitrogen remained unaffected at P &lt; 0.05. Although there were fluctuations, a trend emerged for the reduction of TKN. Combinations of probiotics did not affect NH3, UA, total protein (TP), albumin (ALB), creatine kinase (CK), and UA in the liver. Temporal (Time as a fixed effect) effects were noted for all nitrogenous compounds present in manure. For ammonia, temporal effects were significant due to fluctuation over time. Week 0 had the lowest value followed by weeks 4 and 8. Week 6 had the greatest value. For ammonium nitrogen, week 8 had the lowest value followed by week 0 and 4 with the next highest value. Week 6 had the greatest value. For TKN, week 4 had the lowest value followed by weeks 6 and 8. Week 0 had the greatest value. For TN, weeks 4, 6, and 8 had similar and lowest values followed by week 0 having the greatest value. However, an overall reduction in NH4-N, TKN, and TN was noted. Fluctuations in NH3 (P = 0.0033) and CK (P = 0.0085) were noted for Time. There was also a trend (P = 0.0706) for the increase of UA in serum. Two or more species of probiotics with yeast should be investigated. If the combination is applicable for increasing production measurements and reducing nitrogenous and serum compounds, the most appropriate time to feed the probiotics from day 1 to the end of production should be investigated.
Development of an evidence-informed recommendation guide to facilitate physical activity counseling between oncology care providers and patients in Canada
Authors: Fong Angela J , Sabiston Catherine M , Nadler Michelle B , Sussman Jonathan , Langley Hugh , Holden Rachel , Stokes-Noonan Michaela , Tomasone Jennifer R 
Published: February 2021

Abstract
Decision support aids help reduce decision conflict and are reported as acceptable by patients. Currently, an aid from the American College of Sports Medicine exists to help oncology care providers advise, assess, and refer patients to physical activity (PA). However, some limitations include the lack of specific resources and programs for referral, detailed PA, and physical function assessments and not being designed following an international gold standard (Appraisal of Guidelines for Research and Evaluation [AGREE] II). This study aimed to develop a recommendation guide to facilitate PA counseling by assessing the risk for PA-related adverse events and offering a referral to an appropriate recommendation. Recommendation guide development followed AGREE II, and an AGREE methodologist was consulted. Specifically, a stakeholder group of oncology care providers and cancer survivors were engaged to develop the assessment criteria for comorbidities, PA levels, and physical function. Assessment criteria were developed from published PA interventions, consultations with content experts, and targeted web-based searches for cancer-specific PA programs. Feedback on the recommendation guide was solicited from stakeholders and external reviewers with relevant knowledge and clinical experience. Independent AGREE methodologists appraised the development process. The recommendation guide is a five-page document, including a preamble, assessment criteria for absolute contraindications to PA, comorbidities, and PA/functional capacity with a list of appropriate resources. Independent AGREE methodologists rated the development process as strong and recommended the guide for use. The recommendation guide has the potential to facilitate PA counseling between oncology care providers and cancer survivors, thus, potentially impacting PA behavior.
Kincore: a web resource for structural classification of protein kinases and their inhibitors
Authors: Modi Vivek , Dunbrack Roland L. 
Published: February 2021

ABSTRACTThe active form of kinases is shared across different family members, as are several commonly observed inactive forms. We previously performed a clustering of the conformation of the activation loop of all protein kinase structures in the Protein Data Bank (PDB) into 8 classes based on the dihedral angles that place the Phe side chain of the DFG motif at the N-terminus of the activation loop. Our clusters are strongly associated with the placement of the activation loop, the C-helix, and other structural elements of kinases. We present Kincore, a web resource providing access to our conformational assignments for kinase structures in the PDB. While other available databases provide conformational states or drug type but not both, KinCore includes the conformational state and the inhibitor type (Type 1, 1.5, 2, 3, allosteric) for each kinase chain. The user can query and browse the database using these attributes or determine the conformational labels of a kinase structure using the web server or a standalone program. The database and labeled structure files can be downloaded from the server. Kincore will help in understanding conformational dynamics of these proteins and guide development of inhibitors targeting specific states. Kincore is available athttp://dunbrack.fccc.edu/kincore.
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity
Authors: Garcia-Beltran Wilfredo F. , Lam Evan C. , Denis Kerri St. , Nitido Adam D. , Garcia Zeidy H. , Hauser Blake M. , Feldman Jared , Pavlovic Maia N. , Gregory David J. , Poznansky Mark C. , Sigal Alex , Schmidt Aaron G. , Iafrate A. John , Naranbhai Vivek , Balazs Alejandro B. 
Published: February 2021

SUMMARYVaccination elicits immune responses capable of potently neutralizing SARS-CoV-2. However, ongoing surveillance has revealed the emergence of variants harboring mutations in spike, the main target of neutralizing antibodies. To understand the impact of these variants, we evaluated the neutralization potency of 99 individuals that received one or two doses of either BNT162b2 or mRNA-1273 vaccines against pseudoviruses representing 10 globally circulating strains of SARS-CoV-2. Five of the 10 pseudoviruses, harboring receptor-binding domain mutations, including K417N/T, E484K, and N501Y, were highly resistant to neutralization. Cross-neutralization of B.1.351 variants was comparable to SARS-CoV and bat-derived WIV1-CoV, suggesting that a relatively small number of mutations can mediate potent escape from vaccine responses. While the clinical impact of neutralization resistance remains uncertain, these results highlight the potential for variants to escape from neutralizing humoral immunity and emphasize the need to develop broadly protective interventions against the evolving pandemic.
COVID-19 Associated Stroke—A Single Centre Experience
Authors: Sundar Uma , Karnik Niteen D , Mukhopadhyay Amita , Darole Pramod , Kolte Shaonak , Bansal Ashank , Gokhale Yojana A , Asole Dnaneshwar , Joshi Anagha , Pednekar Sangeeta , Chavan Swati , Trivedi Trupti , Padwal Namita , Kalekar Lalana , Londhe Charulata , Padhiyar Rupal , Pandey Dharmendra , Yadav Dhirendra , Honrao Sonal U , Bhavsar Prerana , Shah Priyanshu , Gosavi Satish , Wadal Aniket , Shingare Awesh P , Trivedi Mayuri , Oak Gauri Pathak 
Published: February 2021

AbstractBackground and PurposeVarious neurological complications have been reported in association with COVID-19. We report our experience of COVID-19 with stroke at a single center over a period of eight months spanning 1 March to 31 October 2020.MethodsWe recruited all patients admitted to Internal Medicine with an acute stroke, who also tested positive for COVID-19 on RTPCR. We included all stroke cases in our analysis for prediction of in-hospital mortality, and separately analyzed arterial infarcts for vascular territory of ischemic strokes.ResultsThere were 62 stroke cases among 3923 COVID-19 admissions (incidence 1.6%). Data was available for 58 patients {mean age 52.6 years; age range 17–91; F/M=20/38; 24% (14/58) aged ≤40; 51% (30/58) hypertensive; 36% (21/58) diabetic; 41% (24/58) with O2 saturation <95% at admission; 32/58 (55.17 %) in-hospital mortality}. Among 58 strokes, there were 44 arterial infarcts, seven bleeds, three arterial infarcts with associated cerebral venous sinus thrombosis, two combined infarct and bleed, and two of indeterminate type. Among the total 49 infarcts, Carotid territory was the commonest affected (36/49; 73.5%), followed by vertebrobasilar (7/49; 14.3%) and both (6/49; 12.2%). Concordant arterial block was seen in 61% (19 of 31 infarcts with angiography done). ‘Early stroke’ (within 48 hours of respiratory symptoms) was seen in 82.7% (48/58) patients. Patients with poor saturation at admission were older (58 vs 49 years) and had more comorbidities and higher mortality (79% vs 38%). Mortality was similar in young strokes and older patients, although the latter required more intense respiratory support. Logistic regression analysis showed that low GCS and requirement for increasing intensity of respiratory support predicted in-hospital mortality.ConclusionsWe had a 1.6% incidence of COVID-19 related stroke of which the majority were carotid territory infarcts. In-hospital mortality was 55.17%, predicted by low GCS at admission.
Chronic acid-suppressant use and risk of Oesophageal cancer: protocol for a longitudinal study using a large population based cohort
Authors: Hippisley-Cox Julia , Mei Xue W , Tan Pui San , Fitzgerald Rebecca , Coupland Carol , Panday-Ghimire Bhagabati , Offman Judith , Sasieni Peter 
Published: February 2021

AbstractIntroductionOesophageal cancer is the sixth most common cause for cancer related deaths with over 450,000 new cases and 400,000 resulting deaths per year globally. Most cases in the UK are adenocarcinoma with some of the poorest outcomes from this cancer type in Europe -- mainly due to late diagnosis. The main risk factor for oesophageal adenocarcinoma is chronic reflux disease and due to the high prevalence and non-specific nature of these symptoms most patients are often managed with acid-reflux medications (e.g. Proton Pump Inhibitors (PPIs)) without referral for endoscopy. For those patients that are referred the endoscopy is normal in over 70% of cases, and there is not enough capacity within the NHS for endoscopy especially considering colon cancer screening.The primary aim of this project is to improve early identification of individuals at risk of oesophageal cancer and reduce over-use of prescription antacids.Methods and analysisWe will conduct a longitudinal cohort study consisted of adults 40 years and over who are free of oesophageal cancer at study entry, using the QResearch database for data gathered between 2000 and 2020. The main exposure is the use of prescription antacids which includes PPI, H2RA, and other aluminium and magnesium containing antacids. The exposure will be categorised based on active ingredients, dose, and duration of use and will be modelled as a time-varying covariate.Ethics and disseminationEthical approval for this project was obtained from the QResearch Scientific Committee [Ref: OX39, project title “DELTA - integrated Diagnostic solution for Early detection of Oesophageal cAncer”]. This project has been supported by patient and public involvement panels. We intend to submit the findings for peer-reviewed publication in an academic journal and disseminate them to the public.Strength and limitations of this studyThis is an open cohort study comprising a nationally representative sample of English population.The cohort consists of GP clinic data linked to hospital records, the English national cancer registry and English national death registry.This study has access to detailed information on acid-suppressant prescriptions, allowing analysis with consideration of the specific compound, dose, and duration of exposure.This study is limited by high rates of missing data for cancer grade and stage, although completeness has improved in recent years, this will be accounted for using appropriate multiple imputation techniques.
In depth analysis of patients with severe SARS-CoV-2 in sub-Saharan Africa demonstrates distinct clinical and immunological profiles
Authors: Morton B , Barnes KG , Anscombe C , Jere K , Kamng’ona R , Brown C , Nyirenda J , Phiri T , Banda N , Van Der Veer C , Mndolo KS , Mponda K , Rylance J , Phiri C , Mallewa J , Nyirenda M , Katha G , Kambiya P , Jafali J , Mwandumba HC , Gordon SB , Cornick J , Jambo KC 
Published: February 2021

AbstractAlthough the COVID-19 pandemic has left no country untouched there has been limited research to understand clinical and immunological responses in African populations. Here we comprehensively characterise patients hospitalised with suspected or confirmed COVID-19, and healthy community controls. PCR-confirmed COVID-19 participants were more likely to receive dexamethasone and a beta-lactam antibiotic, and survive to hospital discharge than PCR-/IgG+ and PCR-/IgG-participants. PCR-/IgG+ participants exhibited a nasal and systemic cytokine signature analogous to PCR-confirmed COVID-19 participants, but increased propensity for Staphylococcus aureus and Streptococcus pneumoniae colonisation. We did not find evidence that HIV co-infection in COVID-19 participants was associated with mortality or altered cytokine responses. The nasal immune signature in PCR-/IgG+ and PCR-confirmed COVID-19 participants was distinct and predominated by chemokines and neutrophils. In addition, PCR-/IgG+ individuals with high COVID-19 clinical suspicion had inflammatory profiles analogous to PCR-confirmed disease and potentially represent a target population for COVID-19 treatment strategies.
Quantification of the tradeoff between test sensitivity and test frequency in COVID-19 epidemic - a multi-scale modeling approach
Authors: Forde Jonathan E. , Ciupe Stanca M. 
Published: February 2021

AbstractControl strategies that employ real time polymerase chain reaction (RT-PCR) tests for the diagnosis and surveillance of COVID-19 epidemic are inefficient in fighting the epidemic due to high cost, delays in obtaining results, and the need of specialized personnel and equipment for laboratory processing. Cheaper and faster alternatives, such as antigen and paper-strip tests, have been proposed. They return results rapidly, but have lower sensitivity thresholds for detecting virus. To quantify the effects of the tradeoffs between sensitivity, cost, testing frequency, and delay in test return on the overall course of an outbreak, we built a multi-scale immuno-epidemiological model that connects the virus profile of infected individuals with transmission and testing at the population level. We investigated various randomized testing strategies and found that, for fixed testing capacity, lower sensitivity tests with shorter return delays slightly flatten the daily incidence curve and delay the time to the peak daily incidence. However, compared with RT-PCR testing, they do not always reduce the cumulative case count at half a year into the outbreak. When testing frequency is increased to account for the lower cost of less sensitive tests, we observe a large reduction in cumulative case counts, from 57% to as low as 1.5% half a year into the outbreak and to 3.2% three years into the outbreak. The improvement is preserved even when the testing budget is reduced by one half or one third. Our results predict that surveillance testing that employs low-sensitivity tests at high frequency is an effective tool for epidemic control.
Celecoxib exhibits therapeutic potential in experimental model of hyperlipidaemia
Authors: Ekor Martins , Owusu Agyei Phyllis E. , Obese Ernest , Biney Robert P. , Henneh Isaac T. , Antwi-Adjei Meshack , Yahaya Ewura S. , Amoakohene Gordon , Akakpo Patrick K. 
Published: February 2021

AbstractHyperlipidaemia is a major risk factor for cardiovascular diseases, the leading cause of death globally. Celecoxib attenuated hypercholesterolemia associated with CCl4-induced hepatic injury in rats without improving liver function in our previous study. This present study investigated the lipid lowering potential of celecoxib in normal rats fed with coconut oil subjected to five deep-frying episodes. Male Sprague Dawley rats were randomly assigned to groups (n=6 rats/group) which received physiological saline (10 mL/kg), unheated coconut oil (UO, 10 mL/kg) or heated coconut oil (HO, 10 ml/kg) for 60 days. Groups that received HO were subsequently treated with either physiological saline, atorvastatin (25 mg/kg), celecoxib (5 mg/kg) or celecoxib (10 mg/kg) in the last fifteen days of the experiment. Rats were sacrificed 24 hours after last treatment and blood and tissue samples collected for analysis. HO consumption produced significant hyperlipidaemia and elevation in marker enzymes of hepatic function. Celecoxib ameliorated the hyperlipidaemia as shown by the significantly (P<0.05) lower total cholesterol, triglycerides, low and very low density lipoprotein in the celecoxib-treated rats when compared with HO-fed rats that received saline. Celecoxib also reduced (P<0.05) alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and liver weight of hyperlipidaemic rats. Similarly, hepatocellular damage and inflammation of the aorta associated with the hyperlipidaemia was significantly reversed by celecoxib. However, serum TNF-α and IL-6 did not change significantly between the various groups. Taken together, data from this study suggest that celecoxib may exert therapeutic benefit in hyperlipidaemia and its attendant consequences.