bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral submucous fibrosis presenting with histopathological lichenoid changes as predominant feature: Report of five cases and review of the literature
Authors: Campos María C. , Tubau Carla , Segura Sonia , González‐Farré Monica , Iglesias‐Sancho Maribel , Fernández‐Figueras María Teresa , Garcia‐Muret Maria Pilar , Mozos Ana 
Published: June 2021

AbstractOral submucous fibrosis (OSF) is a precancerous condition of the oral cavity associated with habitual chewing of quid, with a high incidence among populations of the Indian subcontinent and Southeast Asia. Clinically, its initial manifestation may mimic oral lichen planus or lichen sclerosus. If the habit is not halted, the mucosa gets leathery and thickened, and fibrous bands form causing significant morbidity. Microscopically, it is characterized by atrophic epithelium, loss of rete ridges, and hyalinization of lamina propria. Of note, these hallmark histopathological features may be overlooked in the unusual presence of lichenoid interface changes, which may lead to the wrong diagnosis. We present herein five cases in which the rare joint appearance of OSF and lichenoid reaction features posed a diagnostic challenge. Due to its progressive nature and malignant potential, the presence of oral lichenoid changes overlying submucous hyalinization, in the right clinical and demographic setting, should raise suspicion of OSF and prompt actions directed at quid‐chewing discontinuation.
Antecedents of psychological Capital at Work: A Systematic Review of Moderator–mediator Effects and a New Integrative Proposal
Authors: Vilariño del Castillo David , Lopez‐Zafra Esther 
Published: June 2021

AbstractPsychological Capital has been proposed as one of the main bases of the current competitive advantage of any organization; therefore, many studies have assessed the effects of this variable on different work environments. However, to date, no study has addressed systematically the existing research on PsyCap as a mediating and moderating variable in the workplace. The aim of this paper is to respond to the need for reconstruction and reinforcement of the theory surrounding PsyCap and to shed light on the factors that seem to influence the PsyCap levels. Studies included in the Web of Science (WOS) and PsycINFO databases from 2004 to 2020 are reviewed. The results show the importance of PsyCap within the fields of creativity, psychological health, performance, job satisfaction, organizational climate, leadership and other emerging issues. Furthermore, we propose a new classification to integrate all these antecedents of PsyCap, which has important theoretical and practical implications.
Le surtravail ou la fragmentation? Transactions familiales et temps de travail en période de COVID‐19
Authors: CLOUET Hadrien 
Published: June 2021

RésuméComment évolue le temps de travail des salariés contraints au télétravail par les mesures sanitaires françaises en 2020? À partir d'une enquête qualitative conduite dans une régie municipale de l'eau, qui associe entretiens, observations directes et questionnaires, l'auteur montre que le télétravail pour motif de COVID‐19 restructure le temps de travail et redistribue le pouvoir de régulation. En période de confinement, la durée du travail s'allonge et les rythmes laborieux se modifient, avec des variations importantes selon la configuration familiale: le confinement en famille jugule l'allongement des journées de travail mais favorise leur fragmentation. Pour les télétravailleurs isolés, les effets sont inversés.
That’s Not Molluscum! A literature review of 109 cases of subepidermal calcified nodules
Authors: Patel Akash D. , Bellet Jane S. 
Published: June 2021

AbstractSubepidermal calcified nodule (SCN) is a rare presentation of idiopathic calcinosis cutis. A literature review was conducted, with 109 cases reported in 268 articles. We report the demographic data, SCN clinical and histological characteristics, common differential diagnoses, and treatments performed from this analysis.
How probiotics impact on immunological parameters in rainbow trout (Oncorhynchus mykiss)? A systematic review and meta‐analysis
Authors: Rahimi Ruhollah , Mirahmadi Seyedeh Atefeh , Hajirezaee Saeed , Fallah Aziz A. 
Published: June 2021

AbstractProbiotics are microbial cells with multifunctional properties including immunostimulatory function in their host. Today, probiotics are widely used for controlling diseases in aquaculture, especially for rainbow trout, Oncorhynchus mykiss, as the most important commercial cold‐water fish in the world. So far, many studies have been conducted on the effect of probiotics on the immune system of rainbow trout, but due to different experimental conditions, these results are different and sometimes inconsistent. Therefore, the aim of the present study was to perform a systematic review and meta‐analysis to eliminate inconsistencies and to clarify the results related to some immune parameters in rainbow trout. This study is the first meta‐analysis study of probiotic‐induced effects on the immune system of rainbow trout. In order to perform meta‐analysis, four Internet databases, PubMed, Scopus, ISI Web of Science and Google Scholar were systematically searched until 27/03/2020 and after receiving related articles, effect sizes related to 10 outcomes including serum and plasma lysozyme activity, ACH50 activity, Ig activity, serum complement activity, phagocytosis activity, serum total protein activity and respiratory burst activity were evaluated by SMD and Hedges' g statistic and 95% CI was calculated from a random effects model. The SYRCL’S risk of bias tool for animal study was also used to assess the quality of the studies. Meta‐analysis was performed for 36 studies by 499 experiments. The effect of probiotics on immunity components was as follows: serum lysozyme activity (p < 0.05), plasma lysozyme activity (p > 0.05), Serum ACH50 activity (p < 0.05), Plasma ACH50 activity (p < 0.05), serum immunoglobulin activity (p < 0.05), plasma immunoglobulin activity (p < 0.05), total serum protein activity (p < 0.05), serum complement activity (p < 0.05), phagocytic activity (p < 0.05) and respiratory burst activity (p > 0.05). In conclusion, the results of the present study showed that, except plasma lysozyme activity and burst activity, probiotics could enhance immune system of rainbow trout.
From the scriptural to the virtual: Indonesian engineering students responses to the digitalization of Islamic education
Authors: Pabbajah Mustaqim , Jubba Hasse , Abdullah Irwan , Pabbajah M. Taufiq Hidayat , Juhansar  
Published: June 2021

AbstractDigitization has transformed how religion is studied, with religious education shifting from text‐based (scriptural) to media‐based (virtual). This study seeks to understand how Muslim young adults in Indonesia have responded to the digitization of Islamic education, examining not only trends in digitals religious education, but also their implications for Islamic education. It employs a qualitative descriptive approach, using observation, interviews, and focus group discussions to collect data. It finds that religious education has transformed from face‐to‐face discussions with religious scholars into mediated online interactions. This has resulted from three factors: the ease and affordability of online religious media, the cost and time efficiency inherent to online media, and the diversity and comprehensiveness of available digital media. This study recommends that future researchers investigate how online media can be used to promote a deeper religious understanding.
Abstract 155: Prevalence and Clinical Correlates of Left Ventricular Hypertrophy by Sokolow-Lyon and Cornell Electrocardiogram Voltage Criteria in Transcatheter Aortic Valve Replacement Patients
Authors: Xiao Emily , Delago Augustin , El-Hajjar Mohammad , Bulibek Batyrjan , Torosoff Mikhail 
Published: June 2021

Background and Hypothesis:
The sensitivity of LVH analysis by ECG voltage criteria in patients with severe aortic valve stenosis undergoing trans-catheter aortic valve replacement (TAVR) has not yet been studied. LVH is expected in the TAVR population and would be reflected in voltage criteria by ECG.

Methods:
A retrospective chart review was conducted in 176 consecutive TAVR patients without ventricular-paced rhythm. ECG data was collected and analyzed by Sokolow-Lyon and Cornell Voltage criteria. Results were compared to transthoracic echocardiogram. Analyses of variation, correlation, chi-square, and logistic regression were used. The study was approved by the institutional IRB.

Results:
Sokolow-Lyon and Cornell Voltage criteria for LVH were present and concordant in 19% (33 of 176) of patients; in 49% (86 of 176) of patients, neither criteria was suggestive for LVH. Only 19% (34 of 176) of patients had LVH by Cornell Voltage and 13% (23 of 176) by Sokolow-Lyon criteria, indicative of poor concordance between these two commonly used ECG criteria for LVH (p<0.0001).

Ejection fraction, aortic valve gradient, aortic valve area, COPD, PVD, prior stroke, dyslipidemia, and hypertension did not affect the prevalence of LVH by either or both criteria.
Women (p<0.01) and patients with rhythm other than atrial fibrillation (p<0.0053) were more likely to have voltage criteria for LVH, while older adults were more likely to meet criteria for LVH. Concordant LVH criteria were noted in patients 84.6 +/- 7.2 years of age, while patients without LVH by ECG voltage criteria were significantly younger at 80.21 +/- 8.1 years of age (p<0.007).

Conclusion:
The presence of LVH by Sokolow-Lyon and Cornell ECG voltage criteria poorly correlates with the presence of LVH and critical aortic stenosis in TAVR patients. Women are more likely to have voltage criteria for LVH. Therefore, ECG may not be a suitable method of screening patients with severe aortic stenosis for LVH, especially in men.
Abstract 109: Association of Endothelial Dysfunction with Non-invasive Measures of Vascular Stiffness in Young-middle Aged Non-hypertensive Individuals
Authors: Cheng Cynthia , Townsend Raymond , Chirinos Julio A , Keith Scott 
Published: June 2021

Arterial stiffness and enhanced wave reflections independently predict cardiovascular risk. Wave reflections augment central (aortic) pulse pressure (PP), an index of arterial stiffness, and systolic pressure. Increased wave reflections and PP have previously been associated with endothelial dysfunction in hypertensive and healthy middle-aged adults. The study objective was to determine whether endothelial dysfunction is associated with PP and other measures of vascular stiffness in young normotensive and prehypertensive subjects.
We measured office, central, and 24-hour measurements in 102 (64 female, 38 male) non-hypertensive, non-diabetic participants. Endothelial function was assessed non-invasively using post-ischemic reactive hyperemia with strain-gauge plethysmography.
The racially diverse subject pool was comprised of 60% Caucasians, 18% African Americans, and 24% Asians, with mean age 30, mean BMI 25.6, mean office SBP/DBP = 110 ± 13 mm Hg/70 ± 9 mm Hg. Endothelial function was highly associated with office (β= - 4.2 mm Hg, p<0.001) and 24-hour PP (β= - 1.4 mm Hg, p=0.008), along with central measures of wave reflection: ((augmentation pressure (β= - 2.1 mm Hg), augmentation index (β= - 3.7): both p<0.001). Beta values correspond to the change noted for one standard deviation in endothelial function.
In conclusion, endothelial dysfunction is significantly and consistently associated with arterial stiffness and increased wave reflections in young non-hypertensive adults. Identification of endothelial dysfunction in otherwise healthy young individuals may provide an opportunity to reduce vascular stiffness and associated cardiovascular risk.
Abstract P285: Diastolic Dysfunction After Estrogen Loss is Linked to Cardiac Chymase in WKY but Not SHR Rats
Authors: Wang Hao , da Silva Jacqueline , Gabriel-Costa Daniele , Ahmad Sarfaraz , Sun Xuming , Lin Marina , Sudo Roberto T , Varagic Jasmina , Ferrario Carlos , Zapata-Sudo Gisele , Groban Leanne 
Published: June 2021

Left ventricular diastolic dysfunction (LVDD) develops in response to hypertension and estrogen (E2) loss and is consequent to heart failure in women. To understand the mechanisms underlying the development of LVDD as a result of the interaction between E2 loss and the cardiac RAS, we compared the relationships of LV tissue RAS components and E/e′ between adult SHR (n=13) and WKY (n=9) female rats after ovariectomy (OVX) or sham surgery (intact). In intact rats, E/e′ was higher in SHR vs. WKY rats (P<0.05 strain effect) and after OVX, the diastolic phenotype of WKY’s mimicked that of intact SHR counterparts (Figure).
While relationships between RAS enzymatic activities and E/e′ were not significant in SHRs with respect to estrogen status (data not shown), OVX-induced increases in E/e′ were significantly linked to increases in chymase gene expression and enzymatic activity in the WKY strain (Figure). These data indicate that 1) the altered diastolic function in SHR is relatively insensitive to loss of estrogen while the opposite is true in WKY rats, and 2) OVX-induced LVDD in WKY is directly related to increases in cardiac chymase activity. Further elucidation of the interplay between an activated cardiac chymase-mediated RAS metabolism and LVDD following estrogen loss in normotensive subjects is warranted.
Abstract 416: Pluripotent Stem Cell Signaling in Pediatric Heart Failure Patients
Authors: Woulfe Kathleen C , Tatman Phillip , Karimpour-Fard Anis , Jiang Xuan , Nunley Karin , Miyamoto Shelley D , Stauffer Brian L , Sucharov Carmen C 
Published: June 2021

Pediatric heart failure is a heterogeneous disease process with congenital heart disease being the most common indication for heart transplantation in infants, and dilated cardiomyopathy (DCM) the most common indication in older children. Due to limitations of studying pediatric populations, there is no specific therapy for children with DCM. Importantly, the application of proven adult therapies to pediatric patients with DCM has resulted in no substantial improvement in survival over the past three decades. Therefore, there is a clear need for new approaches to better understand this disease process.
In this study, we investigated global cardiac transcriptome and circulating serum proteome changes in pediatric patients with idiopathic dilated cardiomyopathy (IDC) and non-failing controls. Changes were identified in cytokine signaling, signal transduction, and transcription in pediatric IDC patients when compared to non-failing controls. Interestingly, these changes closely resemble the induction of stem cell pluripotency and signaling in resting stem cell populations. Importantly, the transcriptome changes are age-specific and were not observed in adult IDC patients. In addition, the protein profile in serum from pediatric IDC patients identified several factors related to inflammation, and treatment of cardiomyocyte-derived induced pluripotent stem cells (iPSC) with pediatric IDC serum recapitulated pathologic changes in gene expression, including expression of genes altered in the failing pediatric heart. These findings suggest that pathologic changes in cardiomyocytes may be triggered by circulating factors present in the serum resulting in pluripotent and stem cell signaling. These results provide several novel targets for future research and therapeutic intervention.
Abstract 74: Cardioprotective Effect of Growth Hormone Releasing Hormone in Mouse Model of Heart Failure with Preserved Ejection Fraction
Authors: Kanashiro-Takeuchi Rosemeire M , Takeuchi Lauro M , Dulce Raul A , Hardin Darrell , Zuttion Marilia , Balkan Wayne , Cai Ren Z , Schally Andrew V , Hare Joshua M 
Published: June 2021

Heart failure with preserved ejection fraction (HFpEF) is characterized by impaired relaxation, ventricular stiffening and fibrosis. We previously showed that activation of GHRH receptor markedly reduces fibrosis in rat and swine models of ischemic myocardial injury. Therefore, we hypothesized that activation of GHRH receptor signaling can improve diastolic dysfunction in a mouse model of HFpEF.
C57BL6N mice (n=4-5) were implanted with a mini-osmotic pump to deliver angiotensin-II (Ang-II: 0.8 mg/kg/day) for 4 weeks and randomly assigned to receive daily injections of GHRH-Agonist (GHRH-A [MR-409]: 100 μg/kg) or vehicle (DMSO+propylene-glycol). Cardiac performance was assessed by serial echocardiography and hemodynamic analysis.
Chronic administration of Ang-II resulted in increased end-diastolic pressure (EDP, p=0.0186) with no changes in EF (p=ns) or end-systolic pressure (ESP, p=ns) in comparison to control mice. Isovolumetric relaxation time (IVRT, p<0.05) and end-diastolic pressure-volume relationship (EDPVR, p=0.0229) were markedly increased in the Ang-II group consistent with increased ventricular stiffness and poor myocardial relaxation. MR-409 treatment reset these parameters to normal levels (table 1).
Our findings demonstrate that chronic administration of Ang-II mediates structural and functional changes that mimic HFpEF. Importantly, MR-409 treatment reduces Ang-II-induced elevation of EDP, EDPVR and IVRT; thus preventing HFpEF–like effects, suggesting that activation of the GHRH receptor signaling pathways represents a potential new therapeutic approach for HFpEF.
Abstract 93: The Role of the Stretch-responsive Genes Mlf1 and Rnd1 for Cardiac Physiology and Pathophysiology
Authors: Kluge Annika , Pott Jost , Rangrez Ashraf Y , Bernt Alexander , Stiebeling Katharina , Frey Norbert , Frank Derk 
Published: June 2021

Cardiac remodeling is a typical change in function and morphology of the heart in response to pathological biomechanical stress. Despite substantial research in this area several underlying mechanisms remain unclear. We thus devised a screening experiment of dynamic stretch of neonatal cardiomyocytes (NRVCM) which revealed several genes which have not yet been implicated in cardiac remodeling before. In further analyses we focused on
Mlf1
and
Rnd1
, both showing significant expression in heart as well as in skeletal and liver. Conformational qRT-PCR revealed upregulation of Rnd1 mRNA (5.94x) after 24 h of stretch. Mlf1 mRNA was significantly downregulated (qRT-PCR 0.34x). Stimulation with phenylephrine (PE) induced Rnd1 mRNA (3.98x), while Mlf1 mRNA levels remained unchanged. Furthermore, in line with the
in vitro
results we found upregulation of Rnd1 (2.1x, p<0.001) and downregulation of the cardiac Mlf1 expression (var. 1 0.45x, var. 2 0.36x, both p<0.001) in mice after transverse aortic constriction.

Adenoviral overexpression of Mlf1 in NRVCM induced the fetal gene program (e.g.,
nppa
,
nppb
). However, a significant decrease in cell size was found. We noticed the consistent findings after stretch or PE-stimulation. Rnd1 overexpression also led to induction of
nppa
,
nppb
and Rcan1.4, but caused an increase in cell size.

To analyze whether Mlf1 and Rnd1 also influenced cell proliferation, we analyzed Mlf1/Rnd1-infected cells for the expression of proliferation markers Ki67 and phosphohistone H3 (PHH3). Mlf1 overexpression led to an increase in Ki67+ cells of about 5.92 fold, and in PHH3+ cells of 2.48 fold (p<0.001), Rnd1 overexpression showed an increase in Ki67+ cells of about 6.9 fold and in PHH3+ cells of 5,25 fold (p<0.001).
Taken together, we could identify two stretch-sensitive genes which influence the process of cardiac hypertrophy and cell proliferation. Current work focuses on a knockdown of both genes in vivo and on the identification of potential protein-protein interactions to complete the characterization of Mlf1 and Rnd1.
Abstract TP412: Predicting Pharmacokinetic versus Pharmacodynamic Aspirin Resistance in Patients
Authors: Westphal Erica S , Rainka Michelle M , Amsler Michelle , Aladeen Traci , Snyder Caitlin , Bates Vernice , Gengo Fran M 
Published: June 2021

20%-40% of patients being treated with aspirin for secondary prophylaxis of stroke or myocardial infarction may derive no antiplatelet effects. Early identification of patients as pharmacokinetically or pharmacodynamically resistant to aspirin has the potential to become an invaluable clinical tool, reducing delays to optimal treatment, cardiovascular events, and healthcare costs. This study tested the capability of an assay that was previously developed in healthy volunteers, to differentiate between these two types of resistance in patients.
Patients who needed aspirin treatment in the course of normal medical care were included. Dose escalation of chewable aspirin from 81 mg, to 162 mg, to a maximum 325 mg daily occurred every 10-14 days based on the results of whole blood impedance aggregation testing to the agonists, collagen (1 ug/mL, 5 ug/mL) and arachidonate (0.5 mM). The in vitro test was conducted in triplicate by performing the same aggregometry test on blood samples spiked to a concentration of 10 uM of aspirin in 0.05% dimethyl sulfoxide. Resistance was defined as a response to collagen 1 ug/mL >10 ohms, and/or response to arachidonate >6 ohms, and/or the ratio of collagen 1 to 5 ug/mL >0.5. Patients were excluded if they had any disorders affecting platelet function, an abnormal CBC, alcohol use within 24 hours of a test, NSAID use, or had any conditions that would affect absorption.
Of the 36 patients included who were compliant with their 81 mg aspirin regimen based on pill count, 16 were found to be resistant to 81 mg of aspirin. Nine of these patients were predicted to stay resistant despite dose increase. Once tested at higher doses, ten actually remained resistant. Seven of the 16 patients were predicted to become sensitive to a higher dose of aspirin while six actually did. No statistical difference was found between predicted aspirin response and actual aspirin response (p=0.61). Sensitivity was 83% and specificity was 80%.
In conclusion, results are promising and indicate that it is possible to predict, with reasonable accuracy, if a patient will have an adequate platelet response to aspirin or if the patient will never respond to aspirin therapy necessitating an alternative antiplatelet regimen. Larger, multi-site studies are inevitably needed.