bluuebunny/crossref_metadata_2025_split huggingface dataset:
Absolute Quantification of Phosphorylated ERβ Amino Acids in the Hippocampus of Women and in A Rat Model of Menopause
Authors: Zhang Mengjie , Flury Sarah , Kim Chun K , Chung Wilson C J , Kirk Jonathan A , Pak Toni R 
Published: June 2021

Abstract
The rapid decline of circulating 17β-estradiol (E2) at menopause leads to negative neurological consequences, although hormone therapy paradoxically has both harmful and positive effects depending on the age at which it is delivered. The inconsistent response to E2 suggests unappreciated regulatory mechanisms for estrogen receptors (ERs), and we predicted it could be due to age-related differences in ERβ phosphorylation. We assessed ERβ phosphorylation using a sensitive mass spectrometry approach that provides absolute quantification (AQUA-MS) of individually phosphorylated residues. Specifically, we quantified phosphorylated ERβ in the hippocampus of women (aged 21-83 years) and in a rat model of menopause at 4 residues with conserved sequence homology between the 2 species: S105, S176, S200, and Y488. Phosphorylation at these sites, which spanned all domains of ERβ, were remarkably consistent between the 2 species, showing high levels of S105 phosphorylation (80%-100%) and low levels of S200 (20%-40%). Further, S200 phosphorylation decreased with aging in humans and loss of E2 in rats. Surprisingly, Y488 phosphorylation, which has been linked to ERβ ligand-independent actions, exhibited approximately 70% phosphorylation, unaltered by species, age, or E2, suggesting ERβ’s primary mode of action may not require E2 binding. We further show phosphorylation at 2 sites directly altered ERβ DNA-binding efficiency, and thus could affect its transcription factor activity. These findings provide the first absolute quantification of ERβ phosphorylation in the human and rat brain, novel insights into ERβ regulation, and a critical foundation for providing more targeted therapeutic options for menopause in the future.
A Pilot Trial: Fish Oil and Metformin Effects on ApoB-Remnants and Triglycerides in Women With Polycystic Ovary Syndrome
Authors: Vine Donna , Proctor Ethan , Weaver Olivia , Ghosh Mahua , Maximova Katerina , Proctor Spencer 
Published: June 2021

Abstract

Context
Women with polycystic ovary syndrome (PCOS) have increased incidence of atherogenic dyslipidemia and cardiovascular disease (CVD). Interventions targeting atherogenic dyslipidemia to reduce CVD risk are limited in women with PCOS.

Objective
This pilot study was conducted to determine the effect of 12 weeks of high dose fish oil (FO), metformin, and FO as an adjunct to metformin (FO-metformin) therapy on fasting and nonfasting plasma lipids and ApoB-remnants in young women with the metabolic syndrome (MetS) and PCOS.

Methods
In this open-label parallel pilot trial, women with MetS and PCOS (18-30 years of age) were randomized into 1 of 3 interventions: (1) FO; (2) metformin; and (3) FO-metformin. Plasma lipids and ApoB (48 and 100)-lipoproteins and triglycerides (TG) were measured in the fasted and postprandial state following a high-fat meal at baseline and postintervention.

Results
FO-metformin significantly lowered fasting plasma TG by &gt;40% compared with FO and metformin treatments. Fasting plasma apoB48 was lowered 40% in FO-metformin and 15% in the FO groups from baseline to postintervention. ApoB48 area under the curve (ApoB48AUC), ApoB48 incremental AUC (ApoB48iAUC), ApoB100AUC, and ApoB100iAUC decreased in all groups from baseline to postintervention; however, these findings did not reach statistical significance.

Conclusion
The findings of this pilot trial show that high dose FO and FO-metformin combination therapy tend to lower fasting and postprandial plasma TG and ApoB-lipoprotein remnants compared with metformin; however, the study is limited by small sample size. These results may be clinically significant in individuals with PCOS for management of atherogenic dyslipidemia.
A Novel Liver-targeted Testosterone Therapy for Sarcopenia in Androgen Deprived Men With Prostate Cancer
Authors: Rhee Handoo , Navaratnam Anojan , Oleinikova Irina , Gilroy Deborah , Scuderi Yolanda , Heathcote Peter , Nguyen Tuan , Wood Simon , Ho Ken K Y 
Published: June 2021

Abstract

Objective
Androgen deprivation therapy (ADT) reduces muscle and bone mass, increasing frailty in men with prostate cancer. The liver mediates the whole body anabolic effects of testosterone. Based on first-pass metabolism, liver-targeted testosterone treatment (LTTT) entails oral delivery of a small dose of testosterone that does not raise peripheral blood testosterone levels. LTTT reduces blood urea and stimulates protein anabolism in hypogonadal men and postmenopausal women. We investigated whether LTTT prevents loss of lean and bone mass during ADT.

Method
A 6-month, double-blind, placebo-controlled study of testosterone 40 mg/day in 50 men. Primary outcome measures were lean mass and bone mineral content (BMC). Testosterone, urea and prostate-specific antigen (PSA) were monitored. Patients were withdrawn if PSA exceeded 4 ng/mL.

Results
42 patients completed the study. Mean (95% CI) testosterone rose during LTTT but not placebo treatment [∆ 2.2 (1.3-3.0) vs −0.7 (−1.5 to 0.2) nmol/L; P &lt; 0.01]. Mean PSA level did not change significantly during either treatment. Blood urea fell [∆ −0.4 (−0.9 to −0.1) mmol/L] during LTTT but not placebo [∆ 0.05 (−0.8 to 0.9) mmol/L]. BMC [∆ 49 (5 to 93) g; P &lt; 0.02] and lean mass [∆ 0.8 (−0.1 to 1.7) kg; P = 0.04) increased compared to placebo. Five patients on LTTT withdrew from increased PSA levels, all returning to baseline levels.

Conclusion
LTTT shows promise as a simple therapy for preventing sarcopenia and bone loss during ADT. LTTT may induce reversible PSA rise in some patients. Further studies are required to optimize LTTT dose in ADT. LTTT has potential application in other catabolic states in men and women.
Can gray values be converted to Hounsfield units? A systematic review
Authors: Eguren Marjorie , Holguin Anderson , Diaz Karla , Vidalon Jose , Linan Carlos , Pacheco-Pereira Camila , Lagravere Vich Manuel Oscar 
Published: June 2021

Objectives: The purpose of this systematic review was to answer the focus question: “Could the gray values (GVs) from CBCT (cone beam computed tomography) be converted to Hounsfield units (HUs) in multidetector computed tomography (MDCT)?” Methods: The included studies try to answer the research question according to the PICO strategy. Studies were gathered by searching several electronic databases and partial grey literature up to January 2021 without language or time restrictions. The methodological assessment of the studies was performed using The Oral Health Assessment Tool (OHAT) for in vitro studies and the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) for in vivo studies. The Grading of Recommendations Assessment, Development and Evaluation (GRADE system) instrument was applied to assess the level of evidence across the studies. Results: 2710 articles were obtained in Phase 1, and 623 citations remained after removing duplicates. Only three studies were included in this review using a two-phase selection process and after applying the eligibility criteria. All studies were methodologically acceptable, although in general terms with low risks of bias. There are some included studies with quite low and limited evidence estimations and recommendation forces; evidencing the need for clinical studies with diagnostic capacity to support its use. Conclusions: This systematic review demonstrated that the GVs from CBCT cannot be converted to HUs due to the lack of clinical studies with diagnostic capacity to support its use. However, it is evidenced that three conversion steps (equipment calibration, prediction equation models, and a standard formula (converting GVs to HUs)) are needed to obtain pseudo Hounsfield values instead of only obtaining them from a regression or directly from the software.
‘It's just part of the disease’: a qualitative study exploring help-seeking behaviours for fatigue in inflammatory bowel disease
Authors: Dhálaigh Doireann Ní , Greaney Anna Marie , Farrell Dawn 
Published: June 2021

Background: Fatigue is the most burdensome aspect of inflammatory bowel disease (IBD). Despite this, people tend not to discuss fatigue or seek help. Aims: To uncover the reasons people do or do not seek help for fatigue in IBD. Methods: A qualitative approach was employed, underpinned by the Theory of Planned Behaviour. Semi-structured interview questions were posed to a voluntary sample of 12 participants with self-reported diagnosis of IBD fatigue, recruited from the Irish Society of Colitis and Crohn's. The sample included individuals who had and had not sought help in the past. Findings: The availability of management options, symptom perception, symptom impact, knowledge of sources of help and inferiority of fatigue as a symptom can influence help-seeking behaviour. Fatigue is viewed as inferior to other symptoms of IBD, which influences help-seeking behaviour and help-seeking experiences. Conclusions: Health professionals can increase help-seeking by informing patients about the symptom and identifying a specific source of help for fatigue.
Effect of residual lower-extremity function on strategies and execution time for raising and lowering trousers in patients with hemiparetic stroke: a cross-sectional study
Authors: Iwata Kenji , Koyama Soichiro , Yamazaki Toshihiro , Kimura Keisuke , Sakurai Hiroaki , Kanada Yoshikiyo 
Published: June 2021

Background/aims There are no established methods for patients with hemiparetic stroke to practice the raising and lowering of trousers. The aim of this study was to investigate the use of different strategies by patients with hemiparetic stroke for lowering and raising trousers by using the non-paretic upper limb in the standing position, based on residual motor function in the paretic lower limb. Methods A total of 28 patients with hemiparetic stroke were included in the study (n=10, 12, and 6 with lower-limb Brunnstrom stages III, IV and V respectively). Endpoints were execution time and frequency of changing the manipulation region. Results Lower-limb Brunnstrom stages III, IV and V were associated with execution times of 24.1 ± 11.1, 18.1 ± 6.5 and 16.9 ± 9.6 seconds respectively, and the mean frequency of manipulation of trousers on the posterior paretic side was significantly lower than those of the anterior paretic, anterior non-paretic, and posterior non-paretic sides in all patients (P<0.05). Conclusions Motor function of the paretic lower limb did not affect the strategies used for lowering and raising trousers with the non-paretic upper limb. Manipulation of trousers on the posterior paretic side was especially difficult.
EM DEFESA DE UM DOGMA - GRICE E STRAWSON
Authors: Moreira Jorge 
Published: June 2021

O presente texto foi publicado pela primeira vez em 1956, na revista The Philosophical Review, que apresenta uma discussão muito relevante para a filosofia contemporânea no século XX, a saber, a discussão acerca da crítica que Quine realiza contra os dogmas do empirismo. No artigo intitulado Two Dogmas of Empiricism, publicado no livro From a Logical Point of View, Quine ataca a distinção clássica entre enunciados analíticos e enunciados sintéticos. Grice e Strawson pretendem, no presente artigo, argumentar contrariamente à crítica feita por Quine, pois consideram que o autor exige demasiadamente o estabelecimento de critérios que suportem a afirmação da distinção mencionada. Por fim, o artigo dos autores pretende mostrar como o uso estabelecido da distinção é aceitável, uma vez que ela auxilia na resolução de algumas demarcações filosóficas. A presente tradução foi feita a partir do texto original, publicado em 1956.O presente texto foi publicado pela primeira vez em 1956, na revista The Philosophical Review, que apresenta uma discussão muito relevante para a filosofia contemporânea no século XX, a saber, a discussão acerca da crítica que Quine realiza contra os dogmas do empirismo. No artigo intitulado Two Dogmas of Empiricism, publicado no livro From a Logical Point of View, Quine ataca a distinção clássica entre enunciados analíticos e enunciados sintéticos. Grice e Strawson pretendem, no presente artigo, argumentar contrariamente à crítica feita por Quine, pois consideram que o autor exige demasiadamente o estabelecimento de critérios que suportem a afirmação da distinção mencionada. Por fim, o artigo dos autores pretende mostrar como o uso estabelecido da distinção é aceitável, uma vez que ela auxilia na resolução de algumas demarcações filosóficas. A presente tradução foi feita a partir do texto original, publicado em 1956.
DEBATENDO O PONTO DE VISTA PRÁTICO-POIÉTICO DE CRISÓSTOMO
Authors: Pereira Leonardo Jorge da Hora , Souza José Crisóstomo de 
Published: June 2021

O debate começa pelo questionamento, por Leonardo Pereira, do possível caráter abstrato, demasiado geral, da noção, central à posição prático-poiética de Crisóstomo de Souza, da ação humana como poiésis e de nosso envolvimento básico com o mundo como um emaranhamento sensível prático criativo, de cujo caráter poderia resultar um déficit explicativo e também normativo. E se desenvolve no questionamento da atribuição àquela ação de um caráter de produção de artefatos, e também da atribuição de um alegado caráter artefatual à própria realidade humana, que então não poderia ser propriamente apreendida como estrutura ou sistema, condicionamento e circunstância. Que assim tampouco poderia ser criticada - no marco do que parece ser um viés idealista romântico - por suas eventuais deformações nesse nível, em termos p. ex. de alienação, ocultação etc. Nesse quadro, a técnica tampouco seria suficientemente criticada por sua eventual dependência de uma nociva metafísica objetivista ou por sua determinação pelas imposições da ordem capitalista. Para Crisóstomo, que oferece em traços rápidos uma interpretação diferente para cada um desses casos, tais desafios resultam mais bem explicados na consideração do conjunto de seus textos mais recentes sobre seu ponto de vista prático. Que, admite Leonardo, poderia ter interesse como uma bem-vinda ruptura com posições tanto positivistas como linguocêntricas. Ou, em vez disso, ainda poderia permanecer presa a reducionismos próprios a outro paradigma produtivo, o de Marx. Mas, para Crisóstomo, suas noções de poiésis e intencionalidade sensível na verdade enriquecem uma noção mais material, efetiva, normativa, de autonomia humana, como suporte para uma noção transformativa mais promissora, crítica e inovadora, de democracia e de cidadania materiais, para além daqueles três paradigmas.
Anne på svenska
Authors: Vogel Anna 
Published: June 2021

Anne in Swedish. How the Spirit of the Age and Production Terms Influence the Protagonist’s Character Traits in Swedish Translations and Adaptations of Anne of Green Gables
L.M. Montgomery’s Anne of Green Gables (1908) has received much academic interest. Drawing on related research on the novel and its Swedish editions, my article investigates how the variation in the Swedish versions influences the characterization of Anne 1909–2018. My study acknowledges the feminist view within translation studies as expressed by Sherry Simon, and uses Norman Fairclough’s linguistic model for contextualization. The primary material consists of Montgomery’s original text, the translations and adaptations by Karin Jensen, Aslög Davidson, Margareta Sjögren-Olsson, and Christina Westman as well as correspondence between the publishing houses and translators. Further, I have interviewed Westman and corresponded with her publisher. The texts are analysed regarding omissions and additions. On a micro-level, all active verbs where Anne is the grammatical subject are analysed. My results show that all editions give prominence to Anne’s academic ambition. A major finding is that the 1941 and 1962 versions increase Anne’s ambition by using more active verbs and stronger expressions. Westman’s 2018 edition, however, is a subtle revision of the first Swedish translation, with the result that Anne’s ambition is diminished again. Despite girls and women having gained more freedom over the last 100 years, the latest edition thereby interrupts the tendency to stress Anne’s ambition. This is understood as a result of clashing discursive and social norms. On the other hand, the emphasis on Anne’s ambition in the 1941 and 1962 editions comes with a cost of religious, moral, intellectual, and emotional aspects, creating a one-dimensional Anne.
Optimality of Serrin type extension criteria to the Navier-Stokes equations
Authors: Farwig Reinhard , Kanamaru Ryo 
Published: June 2021

AbstractWe prove that a strong solutionuto the Navier-Stokes equations on (0,T) can be extended if eitheru∈Lθ(0,T;U˙∞,1/θ,∞−α$\begin{array}{} \displaystyle \dot{U}^{-\alpha}_{\infty,1/\theta,\infty} \end{array}$) for 2/θ+α= 1, 0 <α< 1 oru∈L2(0,T;V˙∞,∞,20$\begin{array}{} \displaystyle \dot{V}^{0}_{\infty,\infty,2} \end{array}$), whereU˙p,β,σs$\begin{array}{} \displaystyle \dot{U}^{s}_{p,\beta,\sigma} \end{array}$andV˙p,q,θs$\begin{array}{} \displaystyle \dot{V}^{s}_{p,q,\theta} \end{array}$are Banach spaces that may be larger than the homogeneous Besov spaceB˙p,qs$\begin{array}{} \displaystyle \dot{B}^{s}_{p,q} \end{array}$. Our method is based on a bilinear estimate and a logarithmic interpolation inequality.
Nontrivial solutions to the p-harmonic equation with nonlinearity asymptotic to |t|
p–2
t at infinity
Authors: He Qihan , Lv Juntao , Lv Zongyan 
Published: June 2021

Abstract
We consider the following p-harmonic problem

Δ

(

|

Δ

u

|

p
−
2

Δ

u
)
+
m

|

u

|

p
−
2

u
=
f
(
x
,
u
)
,
x
∈

R

N

,

u
∈

W

2
,
p

(

R

N

)
,

$$\begin{array}{}
\displaystyle
\left\{ \displaystyle\begin{array}{ll} \displaystyle {\it\Delta} (|{\it\Delta} u|^{p-2}{\it\Delta} u)+m|u|^{p-2}u=f(x,u), \ \ x\in {\mathbb R}^N, \\
u \in W^{2,p}({\mathbb R}^N),
\end{array}
\right.
\end{array}$$

where m > 0 is a constant, N > 2p ≥ 4 and

lim

t
→
∞

f
(
x
,
t
)

|

t

|

p
−
2

t

=
l

$\begin{array}{}
\displaystyle
\lim\limits_{t\rightarrow \infty}\frac{f(x,t)}{|t|^{p-2}t}=l
\end{array}$

uniformly in x, which implies that f(x, t) does not satisfy the Ambrosetti-Rabinowitz type condition. By showing the Pohozaev identity for weak solutions to the limited problem of the above p-harmonic equation and using a variant version of Mountain Pass Theorem, we prove the existence and nonexistence of nontrivial solutions to the above equation. Moreover, if f(x, u) ≡ f(u), the existence of a ground state solution and the nonexistence of nontrivial solutions to the above problem is also proved by using artificial constraint method and the Pohozaev identity.
Ground state solutions for a class of fractional Schrodinger-Poisson system with critical growth and vanishing potentials
Authors: Meng Yuxi , Zhang Xinrui , He Xiaoming 
Published: June 2021

AbstractIn this paper, we study the fractional Schrödinger-Poisson system(−Δ)su+V(x)u+K(x)ϕ|u|q−2u=h(x)f(u)+|u|2s∗−2u,in R3,(−Δ)tϕ=K(x)|u|q,in R3,$$\begin{array}{} \displaystyle \left\{ \begin{array}{ll} (-{\it\Delta})^{s}u+V(x)u+ K(x) \phi|u|^{q-2}u=h(x)f(u)+|u|^{2^{\ast}_{s}-2}u,&\mbox{in}~ {\mathbb R^{3}},\\ (-{\it\Delta})^{t}\phi=K(x)|u|^{q},&\mbox{in}~ {\mathbb R^{3}}, \end{array}\right. \end{array}$$wheres,t∈ (0, 1), 3 < 4s< 3 + 2t,q∈ (1,2s∗$\begin{array}{} \displaystyle 2^*_s \end{array}$/2) are real numbers, (−Δ)sstands for the fractional Laplacian operator,2s∗:=63−2s$\begin{array}{} \displaystyle 2^{*}_{s}:=\frac{6}{3-2s} \end{array}$is the fractional critical Sobolev exponent,K,Vandhare non-negative potentials andV,hmay be vanish at infinity.fis aC1-function satisfying suitable growth assumptions. We show that the above fractional Schrödinger-Poisson system has a positive and a sign-changing least energy solution via variational methods.
Preparation of composite soybean straw-based materials by LDHs modifying as a solid sorbent for removal of Pb(ii) from water samples
Authors: Zhang Fengrong , Zhang Binghan , Han Dandan , Wu Lishun , Hou Wanguo 
Published: June 2021

Abstract
In this study, the nanocomposites from biomass (soybean straw) and layered double hydroxides (LDHs), denoted as B/LDHs, were fabricated using the mechanical-hydrothermal method. The obtained B/LDHs nanocomposites were characterized by TEM, SEM, FT-IR, and N2 adsorption–desorption techniques. Adsorption of the heavy-metal ions Pb(ii) on the B/LDHs was determined at 25°C and pH 6.0 using a batch technique. The experimental results demonstrated that biomass contributed to the sorption process. The pseudo-second-order, Langmuir, and Freundlich models well fitted the sorption process, indicating chemisorption and monolayer adsorption were the main adsorption mechanisms. Meanwhile, it is found that there is an obvious effect of adsorbent concentration in the studied adsorption system. In comparison with soybean straw and Mg–Al LDHs, the B/LDHs nanocomposites exhibit significantly enhanced sorption capacities. It is evident from this study that the construction of B/LDHs nanocomposites is an effective strategy for improving the sorption capacity of LDHs, and the modified LDH-based adsorbent shows a good potential in the removal of heavy metals from water. More importantly, it solves the problem of a large number of agricultural waste disposals. And, it achieved the goal of a win-win situation.
Stroke hospitalization after misdiagnosis of “benign dizziness” is lower in specialty care than general practice: a population-based cohort analysis of missed stroke using SPADE methods
Authors: Chang Tzu-Pu , Bery Anand K. , Wang Zheyu , Sebestyen Krisztian , Ko Yu-Hung , Liberman Ava L. , Newman-Toker David E. 
Published: June 2021

Abstract

Objectives
Isolated dizziness is a challenging stroke presentation in the emergency department, but little is known about this problem in other clinical settings. We sought to compare stroke hospitalizations after treat-and-release clinic visits for purportedly “benign dizziness” between general and specialty care settings.

Methods
This was a population-based retrospective cohort study from a national database. We included clinic patients with a first incident treat-and-release visit diagnosis of non-specific dizziness/vertigo or a peripheral vestibular disorder (ICD-9-CM 780.4 or 386.x [not 386.2]). We compared general care (internal medicine, family medicine) vs. specialty care (neurology, otolaryngology) providers. We used propensity scores to control for baseline stroke risk differences unrelated to dizziness diagnosis. We measured excess (observed>expected) stroke hospitalizations in the first 30 d (i.e., missed strokes associated with an adverse event).

Results
We analyzed 144,355 patients discharged with “benign dizziness” (n=117,117 diagnosed in general care; n=27,238 in specialty care). After propensity score matching, patients in both groups were at higher risk of stroke in the first 30 d (rate difference per 10,000 treat-and-release visits for “benign dizziness” 24.9 [95% CI 18.6–31.2] in general care and 10.6 [95% CI 6.3–14.9] in specialty care). Short-term stroke risk was higher in general care than specialty care (relative risk, RR 2.2, 95% CI 1.5–3.2) while the long-term risk was not significantly different (RR 1.3, 95% CI 0.9–1.9), indicating higher misdiagnosis-related harms among dizzy patients who initially presented to generalists after adequate propensity matching.

Conclusions
Missed stroke-related harms in general care were roughly twice that in specialty care. Solutions are needed to address this care gap.