bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visualizing the Flow Patterns in an Expanding and Contracting Pulmonary Alveolated Duct Based on Microcomputed Tomography Images
Authors: Sera Toshihiro , Kamiya Naoki , Fukushima Taichi , Tanaka Gaku 
Published: February 2021

Abstract
We visualized the flow patterns in an alveolated duct model with breathing-like expanding and contracting wall motions using particle image velocimetry, and then, we investigated the effect of acinar deformation on the flow patterns. We reconstructed a compliant, scaled-up model of an alveolated duct from synchrotron microcomputed tomography images of a mammalian lung. The alveolated duct did not include any bifurcation, and its entire surface was covered with alveoli. We embedded the alveolated duct in a sealed container that was filled with fluid. We oscillated the fluid in the duct and container simultaneously and independently to control the flow and duct volume. We examined the flow patterns in alveoli, with the Reynolds number (Re) at 0.03 or 0.22 and the acinar volume change at 0%, 20%, or 80%. At the same Re, the heterogeneous deformation induced different inspiration and expiration flow patterns, and the recirculating regions in alveoli changed during respiratory cycle. During a larger acinar deformation at Re = 0.03, the flow patterns tended to change from recirculating flow to radial flow during inspiration and vice versa during expiration. Additionally, the alveolar geometric characteristics, particularly the angle between the alveolar duct and mouth, affected these differences in flow patterns. At Re = 0.22, recirculating flow patterns tended to form during inspiration and expiration, regardless of the magnitude of the acinar deformation. Our in vitro experiments suggest that the alveolated flows with nonself-similar and heterogeneous wall motions may promote particle mixing and deposition.
Binder Jetting Additive Manufacturing: Effect of Particle Size Distribution on Density
Authors: Du Wenchao , Roa Jorge , Hong Jaehee , Liu Yanwen , Pei Zhijian , Ma Chao 
Published: February 2021

Abstract
This paper reports a study on the effects of particle size distribution (tuned by mixing different-sized powders) on density of a densely packed powder, powder bed density, and sintered density in binder jetting additive manufacturing. An analytical model was used first to study the mixture packing density. Analytical results showed that multimodal (bimodal or trimodal) mixtures could achieve a higher packing density than their component powders and there existed an optimal mixing fraction to achieve the maximum mixture packing density. Both a lower component particle size ratio (fine to coarse) and a larger component packing density ratio (fine to coarse) led to a larger maximum mixture packing density. A threshold existed for the component packing density ratio, below which the mixing method was not effective for density improvement. Its relationship to the component particle size ratio was calculated and plotted. In addition, the dependence of the optimal mixing fraction and maximum mixture packing density on the component particle size ratio and component packing density ratio was calculated and plotted. These plots can be used as theoretical tools to select parameters for the mixing method. Experimental results of tap density were consistent with the above-mentioned analytical predictions. Also, experimental measurements showed that powders with multimodal particle size distributions achieved a higher tap density, powder bed density, and sintered density in most cases.
Validation of Wearable Camera Still Images to Assess Posture in Free-Living Conditions
Authors: Martinez Julian , Decker Autumn E. , Cho Chi C. , Doherty Aiden , Swartz Ann M. , Staudenmayer John , Strath Scott J. 
Published: February 2021

Purpose: To assess the convergent validity of body-worn wearable camera still images (IMGs) for determining posture compared with activPAL (AP) classifications. Methods: The participants (n = 16, mean age 46.7 ± 23.8 years, 9 F) wore an Autographer wearable camera and an AP during three 2-hr free-living visits. IMGs were on average 8.47 s apart and were annotated with output consisting of events, transitory states, unknown, and gaps. The events were annotations that matched AP classifications (sit, stand, and move), consisting of at least three IMGs; the transitory states were posture annotations fewer than three IMGs; the unknowns were IMGs that could not be accurately classified; and the gaps were the time between annotations. For the analyses, the annotation and AP output were converted to 1-s epochs. The total and average length of visits and events were reported in minutes. Bias and 95% confidence intervals for event posture times from IMGs to AP were calculated to determine accuracy and precision. Confusion matrices using total AP posture times were computed to determine misclassification. Results: Forty-three visits were analyzed, with a total visit and event time of 5,027.73 and 4,237.23 min, respectively, and the average visit and event lengths being 116.92 and 98.54 min, respectively. Bias was not statistically significant for sitting, but was significant for standing and movement (0.84, −6.87, and 6.04 min, respectively). From confusion matrices, IMGs correctly classified sitting, standing, and movement (85.69%, 54.87%, and 69.41%, respectively) of total AP time. Conclusion: Wearable camera IMGs provide a good estimation of overall sitting time. Future work is warranted to improve posture classifications and examine the validity of IMGs in assessing activity-type behaviors.
The Test–Retest Reliability of Bilateral and Unilateral Force Plate–Derived Parameters of the Countermovement Push-Up in Elite Boxers
Authors: Parry Gemma N. , Herrington Lee C. , Horsley Ian G. , Gatt Ian 
Published: February 2021

Context: Maximal power describes the ability to immediately produce power with the maximal velocity at the point of release, impact, and/or take off—the greater an athlete’s ability to produce maximal power, the greater the improvement of athletic performance. In reference to boxing performance, regular consistent production of high muscular power during punching is considered an essential prerequisite. Despite the importance of upper limb power to athletic performance, presently, there is no gold standard test for upper limb force development performance. Objective: To investigate the test–retest reliability of the force plate–derived measures of countermovement push-up in elite boxers. Design: Test–retest design. Setting: High Performance Olympic Training Center. Participants: Eighteen elite Olympic boxers (age = 23 [3] y; height = 1.68 [0.39] m; body mass = 70.0 [17] kg). Intervention: Participants performed 5 repetitions of countermovement push-up trials on FD4000 Forcedeck dual force platforms on 2 separate test occasions 7 days apart. Main Outcome Measures: Peak force, mean force, flight time, rate of force development, impulse, and vertical stiffness of the bilateral and unilateral limbs from the force–time curve. Results: No significant differences between the 2 trial occasions for any of the derived bilateral or unilateral performance measures. Intraclass correlation coefficients indicated moderate to high reliability for performance parameters (intraclass correlation coefficients = .68–.98) and low coefficient of variation (3%–10%) apart from vertical stiffness (coefficient of variation = 16.5%–25%). Mean force demonstrated the greatest reliability (coefficient of variation = 3%). In contrast, no significant differences (P < .001) were noted between left and right limbs (P = .005–.791), or between orthodox or southpaw boxing styles (P = .19–.95). Conclusion: Force platform–derived kinetic bilateral and unilateral parameters of countermovement push-up are reliable measures of upper limb power performance in elite-level boxers; results suggest unilateral differences within the bilateral condition are not the norm for an elite boxing cohort.
Rift inheritance controls the switch from thin- to thick-skinned thrusting and basal décollement re-localization at the subduction-to-collision transition
Authors: Tavani Stefano , Granado Pablo , Corradetti Amerigo , Camanni Giovanni , Vignaroli Gianluca , Manatschal Gianreto , Mazzoli Stefano , Muñoz Josep A. , Parente Mariano 
Published: February 2021

AbstractIn accretionary convergent margins, the subduction interface is formed by a lower plate décollement above which sediments are scraped off and incorporated into the accretionary wedge. During subduction, the basal décollement is typically located within or at the base of the sedimentary pile. However, the transition to collision implies the accretion of the lower plate continental crust and deformation of its inherited rifted margin architecture. During this stage, the basal décollement may remain confined to shallow structural levels as during subduction or re-localize into the lower plate middle-lower crust. Modes and timing of such re-localization are still poorly understood. We present cases from the Zagros, Apennines, Oman, and Taiwan belts, all of which involve a former rifted margin and point to a marked influence of inherited rift-related structures on the décollement re-localization. A deep décollement level occurs in the outer sectors of all of these belts, i.e., in the zone involving the proximal domain of pre-orogenic rift systems. Older—and shallower—décollement levels are preserved in the upper and inner zones of the tectonic pile, which include the base of the sedimentary cover of the distal portions of the former rifted margins. We propose that thinning of the ductile middle crust in the necking domains during rifting, and its complete removal in the hyperextended domains, hampered the development of deep-seated décollements during the inception of shortening. Progressive orogenic involvement of the proximal rift domains, where the ductile middle crust was preserved upon rifting, favors its reactivation as a décollement in the frontal portion of the thrust system. Such décollement eventually links to the main subduction interface, favoring underplating and the upward motion of internal metamorphic units, leading to their final emplacement onto the previously developed tectonic stack.
Yttrium and Lithium Keto-β-Diketiminate Complexes [{2,6-Me2C6H3N=C(Me)}2CС(tert-Bu)=O]2Y(μ2-Cl)2Li(THF)2 and {[{2,6-Me2C6H3N=C(Me)}2CС(tert-Bu)=O]Li(THF)}n. Synthesis, Molecular Structures, and Catalytic Activity in ε-Caprolactone Polymerization
Authors: Skvortsov G. G. , Cherkasov A. V. , Vorozhtsov D. L. , Shchegravina E. S. , Trifonov A. A. 
Published: February 2021

Abstract
The reaction of lithium β-diketiminate [{2,6-Me2C6H3N=CMe}2CH]Li with benzophenone in toluene at 25°C affords the coordination complex [{2,6-Me2C6H3N=CMe}2CH]Li(Ph2C=O) (I). New keto-β-diketimine {2,6-Me2C6H3N=C(Me)}2CHC(tert-Bu)=O (II) is synthesized by the reaction of tert-Bu(C=O)Cl with [{2,6-Me2C6H3N=CMe}2CH]Li. The metallation of keto-β-diketimine II with n-butyllithium in THF at 0°C gives lithium keto-β-diketiminate {[{2,6-Me2C6H3N=C(Me)}2CС(tert-Bu)=O]Li(THF)}n (III). The exchange reaction of YCl3 with compound III (molar ratio 1 : 2, THF) affords the yttrium bis(keto-diketiminate) complex [{2,6-Me2C6H3N=C(Me)}2CС(tert-Bu)=O]2Y(μ2-Cl)2L-(THF)2 (IV). The molecular structures of complexes I, III, and IV are determined by X-ray diffraction analysis (CIF files CCDC nos. 2001131 (I), 2001132 (III), and 2001133 (IV)). Complex IV in the crystalline state exists as an ate complex with one LiCl molecule. Complexes I, III, and IV are catalysts of ring-opening polymerization of ε-caprolactone in toluene at 25°С.
Serum calcification propensity is associated with HbA1c in type 2 diabetes mellitus
Authors: Mencke Rik , van der Vaart Amarens , Pasch Andreas , Harms Geert , Waanders Femke , Bilo Henk J G , van Goor Harry , Hillebrands Jan-Luuk , van Dijk Peter R 
Published: February 2021

IntroductionSerum calcification propensity is emerging as an independent predictor for cardiovascular outcomes in high-risk populations. Calcification propensity can be monitored by the maturation time of calciprotein particles in serum (T50test). A low T50value is an independent determinant of cardiovascular morbidity and mortality in various populations. Aim was to investigate the T50and its relationship to type 2 diabetes mellitus.Research design and methodsUsing nephelometry, serum T50was cross-sectionally measured in 932 stable patients with type 2 diabetes mellitus (55% male) with a median age of 66 (62–75) years, diabetes duration of 6.5 (3.0–10.2) years and hemoglobin A1c (HbA1c) of 49 (44–54) mmol/mol.ResultsSerum T50was normally distributed with a mean value of 261±66 min. In linear regression, serum T50was lower in women and current smokers. A lower T50value was found in patients with a higher HbA1c or higher systolic blood pressure, insulin users and patients with a longer history of diabetes. The association with HbA1c was independent of other determinants in multivariable analysis. There was no association between T50and previous macrovascular events or the presence of microvascular disease.ConclusionsSerum calcification propensity is independently associated with glycemic control, suggesting that a lower HbA1c may be associated with better cardiovascular outcomes. Retrospective analysis could not establish an association between a history of macrovascular events and T50, and prospective studies will have to be performed to address this hypothesis.Trial registration numberNCT01570140.
Missed opportunities for delivering nutrition interventions in first 1000 days of life in India: insights from the National Family Health Survey, 2006 and 2016
Authors: Nguyen Phuong Hong , Avula Rasmi , Tran Lan Mai , Sethi Vani , Kumar Alok , Baswal Dinesh , Hajeebhoy Nemat , Ranjan Alok , Menon Purnima 
Published: February 2021

ObjectivesExisting health and community nutrition systems have the potential to deliver many nutrition interventions. However, the coverage of nutrition interventions across the delivery platforms of these systems has not been uniform. We (1) examined the opportunity gaps between delivery platforms and corresponding nutrition interventions through the continuum of care in India between 2006 and 2016 and and (2) assessed inequalities in these opportunity gaps.MethodsWe used two rounds of the National Family Health Survey data from 2005 to 2006 and 2015–2016 (n=36 850 and 190 898 mother–child dyads, respectively). We examine the opportunity gaps over time for seven nutrition interventions and their associated delivery platforms at national and state levels. We assessed equality and changes in equality between 2006 and 2016 for opportunity gaps by education, residence, socioeconomic status (SES), public and private platforms.ResultsCoverage of nutrition interventions was consistently lower than the reach of their associated delivery platforms; opportunity gaps ranging from 9 to 32 percentage points (pp) during the pregnancy, 17 pp during delivery and 9–26 pp during childhood in 2006. Between 2006 and 2016, coverage improved for most indicators, but coverage increases for nutrition interventions was lower than for associated delivery platforms. The opportunity gaps were larger among women with higher education (22–57 pp in 2016), higher SES status and living in urban areas (23–57 pp), despite higher coverage of most interventions and the delivery platforms among these groups. Opportunity gaps vary tremendously by state with the highest gaps observed in Tripura, Andaman and Nicobar islands, and Punjab for different indicators.ConclusionsIndia’s progress in coverage of health and nutrition interventions in the last decade is promising, but both opportunity and equality gaps remained. It is critical to close these gaps by addressing policy and programmatic delivery systems bottlenecks to achieve universal coverage for both health and nutrition within the delivery system.
One hundred thirty-three observed COVID-19 deaths in 10 months: unpacking lower than predicted mortality in Rwanda
Authors: Musanabaganwa Clarisse , Cubaka Vincent , Mpabuka Etienne , Semakula Muhammed , Nahayo Ernest , Hedt-Gauthier Bethany L , Ng Kamela C S , Murray Megan B , Kateera Fredrick , Mutesa Leon , Nsanzimana Sabin 
Published: February 2021

The African region was predicted to have worse COVID-19 infection and death rates due to challenging health systems and social determinants of health. However, in the 10 months after its first case, Rwanda recorded 10316 cases and 133 COVID-19-related deaths translating to a case fatality rate (CFR) of 1.3%, which raised the question: why does Rwanda have a low COVID-19 CFR? Here we analysed COVID-19 data and explored possible explanations to better understand the disease burden in the context of Rwanda’s infection control strategies.We investigated whether the age distribution plays a role in the observed low CFR in Rwanda by comparing the expected number of deaths for 10-year age bands based on the CFR reported in other countries with the observed number of deaths for each age group. We found that the age-specific CFRs in Rwanda are similar to or, in some older age groups, slightly higher than those in other countries, suggesting that the lower population level CFR reflects the younger age structure in Rwanda, rather than a lower risk of death conditional on age. We also accounted for Rwanda’s comprehensive SARS-CoV-2 testing strategies and reliable documentation of COVID-19-related deaths and deduced that these measures may have allowed them to likely identify more asymptomatic or mild cases than other countries and reduced their reported CFR.Overall, the observed low COVID-19 deaths in Rwanda is likely influenced by the combination of effective infection control strategies, reliable identification of cases and reporting of deaths, and the population’s young age structure.
Awareness of infant safe sleep messages and associated care practices: findings from an Australian cohort of families with young infants
Authors: Cole Roni , Young Jeanine , Kearney Lauren , Thompson John M D 
Published: February 2021

ObjectiveTo investigate primary infant caregiver awareness of the current national public health safe sleep messages and the associations of awareness with care practices.Design and settingA cross-sectional survey in Queensland, Australia. All families with live babies birthed during April–May 2017 were eligible. Questionnaires were distributed when infants were approximately 3 months old.ParticipantsOf the 10 200 eligible families, 3341 (33%) primary caregivers participated.Main outcome measuresParticipants were asked: to recall key safe sleeping messages they were aware of (unprompted); questions about their infant care practices; and to select the current, national six safe sleeping messages (prompted multi-choice).ResultsOverall, the majority of families are aware of sleep-related infant mortality and sudden infant death (3178/3317, 96%); however, approximately one in four caregivers (867/3292, 26%) could not identify the current six messages to promote safer infant sleep in a multi-choice question. Despite being aware of the six key messages, some caregiver practices did not always align with advice (336/2423, 14% were not smoke-free; 349/2423, 14% were not usually supine for sleep; 649/2339, 28% employed practices which may increase risk of head or face covering; 426/2423, 18% were not receiving breastmilk).ConclusionsThere is considerable scope for improvement in parent awareness and ability to recall key safe sleep messages. Awareness of advice does not always translate into safe infant care. Health promotion messaging to encourage safer infant sleep, ultimately aimed at reducing sudden unexpected infant deaths, needs more effective supportive strategies and dissemination if future campaigns are to be successful.
Epithelial–mesenchymal transition and cancer stem cell interactions in breast phyllodes tumours: immunohistochemical evaluation of EZH2, EZR, HMGA2, CD24 and CD44 in correlation with outcome analysis
Authors: Ahmed Syed Salahuddin , Lim Jeffrey Chun Tatt , Thike Aye Aye , Iqbal Jabed , Tan Puay Hoon 
Published: February 2021

AimPhyllodes tumours (PTs) categorised as benign, borderline and malignant, account for 1% of all breast tumours. Histological assessment does not always predict tumour behaviour, hindering determination of the clinical course and management.Epithelial–mesenchymal transition (EMT) is an important process during embryogenesis. Dysregulation of EMT causes loss of cell polarity, decreased intercellular adhesion, increased motility and invasiveness, promoting tumour progression. Similarly, cancer stem cells (CSCs) promote tumour growth, resistance and recurrence. The aim of this study is to evaluate expression of CSC markers; enhancer of zeste homolog 2 (EZH2), CD24 and CD44 and EMT associated proteins; ezrin (EZR) and high-mobility group AT-hook 2 (HMGA2) in PTs.MethodUing tissue microarray sections, immunohistochemistry was performed on 360 PTs. Epithelial and stromal expressions of EZH2, EZR, HMGA2, CD24 and CD44 were evaluated to assess their impact on disease progression and behaviour in correlation with clinicopathological parameters.ResultsStromal expression of EZH2, EZR and HMGA2 was observed in 73 (20.3%), 53 (14.7%) and 28 (7.8%) of tumours, epithelial expression in 121 (35.9%), 3 (0.8%) and 351 (97.5%) tumours, respectively. CD24 and CD44 staining was absent in both components.ConclusionExpression of biomarkers correlated significantly with aggressive tumour traits such as stromal hypercellularity, atypia, mitoses and permeative tumour borders.Stromal expression of EZH2 and EZR shortened disease-free survival and overall survival; HMGA2 expression did not alter patient survival. EZH2 and EZR may thus be useful in predicting PT behaviour.
Patient and provider perceptions of a novel cognitive functioning report for patients with systemic lupus erythematosus: a qualitative study
Authors: Plantinga Laura , Vandenberg Ann , Goldstein Felicia , Jones Brian , Johnson Jeremy , Bowling Christopher Barrett , Dunlop-Thomas Charmayne , Lim Sung Sam , Drenkard Cristina 
Published: February 2021

ObjectiveTo determine whether and how cognitive assessment data should be included in a report for patients with SLE and their providers.MethodsLeveraging experiences from prior studies, we created a cognitive report that included a hypothetical patient’s results on tests of multiple domains based on the NIH Toolbox Fluid Cognition Battery. In focus groups that comprised patients with SLE (two groups) and their providers (two groups), feedback was sought on the presentation of results as well as the potential value of the report in the clinical setting.ResultsFeedback regarding the presentation of the report was generally positive. Both patients with SLE and their providers liked its simple graphics and use of a colour-gradated scale to indicate performance. However, both groups stressed the importance of using non-stigmatising language in describing results. Several potential purposes of the report, including distinguishing cognitive versus other issues, explaining cognitive challenges, improving patient–provider interactions, guiding decision-making, improving functioning or preventing impairment and tracking cognitive function over time, were noted by the participants. Potential barriers, such as inadequate clinical staffing or time and lack of potential treatments for identified issues, were also discussed.ConclusionIn this exploratory study, we found that both patients with SLE and their providers were receptive to the idea of a patient-friendly report of cognitive test results. This study provides important information to guide future pragmatic research to optimise the delivery of cognitive information to patients with SLE.