bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation by electronic patient-reported outcomes of cancer survivors’ needs and the efficacy of inpatient cancer rehabilitation in different tumor entities
Authors: Licht Thomas , Nickels Alain , Rumpold Gerhard , Holzner Bernhard , Riedl David 
Published: March 2021

Abstract
Objective
We investigated cancer survivors’ health-related quality of life (HRQOL), specific deficiencies related to underlying disease or treatment, and benefits of rehabilitation in a large variety of cancer entities.

Patients and methods
Electronic patient-reported outcomes were performed as clinical routine procedures. Cancer survivors underwent a 3-week multidisciplinary inpatient rehabilitation. Twenty-one different cancer entities were analyzed separately before (T0) and by the end (T1) of rehabilitation. HRQOL, symptoms, and functions were assessed with EORTC-QLQ-C30 questionnaire, psychological distress with Hospital Anxiety and Depression Scale (HADS).

Results
Four thousand four hundred one of 5912 rehabilitants were evaluable, having completed both questionnaires at T0 and T1. All function mean scores and HRQOL were lower than in Austrian normal population, while levels of anxiety, depression, and all symptom scores were higher. HRQOL was particularly low in lung, liver, and bladder cancer patients. Maximum anxiety levels were observed in patients with breast and thyroid cancer patients, the highest levels of depression in liver and brain cancer patients. Fatigue was severe in patients with lung, liver, esophageal, bladder cancer, and myeloma patients. Mean scores were also high for pain and insomnia. In the group of all rehabilitants, a highly significant improvement of global HRQOL, anxiety, depression, and all function and symptom scores was observed at T1 (p < 0.001). We noted significant improvement of HRQOL, anxiety, depression, fatigue, emotional, social, role, and physical functions in each cancer entity with medium to large effect sizes. Other recorded symptoms were reduced in the majority of cancers.

Conclusion
Rehabilitation effectively improves psychological distress and HRQOL as a part of treatment for various cancers.
Effect of Compaction Banding on the Hydraulic Properties of Porous Rock: Part I—Experimental Investigation
Authors: Leuthold Julia , Gerolymatou Eleni , Vergara Maximiliano R. , Triantafyllidis Theodoros 
Published: March 2021

AbstractThe mechanical behavior and the influence of compaction banding on the hydraulic properties in soft porous rocks were studied. The tested rock was Calcarenite Tuffeau de Maastricht. In the frame of experimental investigations, triaxial and oedometric tests were conducted under dry and drained conditions. The results demonstrated that the rock is forming discrete compaction bands under high confining stresses and steep angle shear bands under low confining stresses. Permeability measurements during the oedometric and triaxial compression tests under drained conditions demonstrated that the axial permeability decreases with increasing axial strain. The maximum permeability decrease was three orders of magnitude for 40% of axial strain.
On the political economy of compulsory education
Authors: Balestrino Alessandro , Grazzini Lisa , Luporini Annalisa 
Published: March 2021

AbstractWe consider an economy with two categories of agents: entrepreneurs and workers. In laissez-faire, the former gain from having their children educated, while the latter, although they may profit from their own education, have no interest in sending their children to school. We first characterise the preferred education policy-cum-redistributive taxation for the two groups, and find that entrepreneurs favour a compulsory education policy while workers prefer a purely redistributive taxation. Each group would like the policy to be entirely financed by the other group. Then, we introduce a political process with probabilistic voting and verify that an equilibrium with both a compulsory education policy and some redistribution may exist in which the workers are constrained but the entrepreneurs, who benefit from hiring educated workers, are not. The redistribution compensates the workers for being constrained by the education policy.
Local lung coagulation post resection: an ex-vivo porcine model
Authors: Kirschbaum A. , Surowiec Th. M. , Pehl A. , Wiesmann Th. , Bartsch D. K. , Mirow N. 
Published: March 2021

AbstractFollowing non-anatomical resection of lung parenchyma with a Nd:YAG laser, a coagulated surface remains. As ventilation starts, air leakage may occur in this area. The aim of the present study was to investigate, whether additional coagulation either before or after ventilation has an additional sealing effect. Freshly slaughtered porcine heart-lung blocks were prepared. The trachea was connected to a ventilator. Using a Nd:YAG laser (wavelength: 1320 nm, power: 60 W), round lesions (1.5 cm in diameter) with a depth of 1.5 cm were applied to the lung using an 800-μm laser fiber (5 s per lesion). Group 1 (n = 12) was control. Additional coagulation was performed in group 2 (n = 12) without and in group 3 (n = 12) with ventilation restarted. Air leakage (ml) from the lesions was measured. The thickness of each coagulation layer was determined on histological slices. Differences between individual groups were analyzed by one-way ANOVA (significance p < 0.05). After resection, 26.2 ± 2.7 ml of air emerged from the lesions per single respiration in group 1. Air loss in group 2 was 24.6 ± 2.5 ml (p = 0.07) and in group 3 23.7 ± 1.8 ml (p = 0.0098). In comparison to groups 1 and 2 thickness of the coagulation layers in group 3 was significantly increased. After non-anatomical porcine lung resection with a Nd:YAG laser, additional coagulation of the ventilated resection area can reduce air leakage.
Adults, but not preschoolers or toddlers integrate situational constraints in their action anticipations: a developmental study on the flexibility of anticipatory gaze
Authors: Ganglmayer Kerstin , Haupt Marleen , Finke Kathrin , Paulus Markus 
Published: March 2021

AbstractRecent theories stress the role of situational information in understanding others’ behaviour. For example, the predictive coding framework assumes that people take contextual information into account when anticipating other’s actions. Likewise, the teleological stance theory assumes an early developing ability to consider situational constraints in action prediction. The current study investigates, over a wide age range, whether humans flexibly integrate situational constraints in their action anticipations. By means of an eye-tracking experiment, 2-year-olds, 5-year-olds, younger and older adults (together N = 181) observed an agent repeatedly taking one of two paths to reach a goal. Then, this path became blocked, and for test trials only the other path was passable. Results demonstrated that in test trials younger and older adults anticipated that the agent would take the continuous path, indicating that they took the situational constraints into account. In contrast, 2- and 5-year-olds anticipated that the agent would take the blocked path, indicating that they still relied on the agent’s previous observed behaviour and—contrary to claims by the teleological stance theory—did not take the situational constraints into account. The results highlight developmental changes in human’s ability to include situational constraints in their visual anticipations. Overall, the study contributes to theories on predictive coding and the development of action understanding.
Deep graph similarity learning: a survey
Authors: Ma Guixiang , Ahmed Nesreen K. , Willke Theodore L. , Yu Philip S. 
Published: March 2021

AbstractIn many domains where data are represented as graphs, learning a similarity metric among graphs is considered a key problem, which can further facilitate various learning tasks, such as classification, clustering, and similarity search. Recently, there has been an increasing interest in deep graph similarity learning, where the key idea is to learn a deep learning model that maps input graphs to a target space such that the distance in the target space approximates the structural distance in the input space. Here, we provide a comprehensive review of the existing literature of deep graph similarity learning. We propose a systematic taxonomy for the methods and applications. Finally, we discuss the challenges and future directions for this problem.
Parental age and birth defects: a sibling study
Authors: Hvide Hans K. , Johnsen Julian , Salvanes Kjell G. 
Published: March 2021

AbstractHigher parental age at childbearing has generated much attention as a potential risk factor for birth disorders; however, previous research findings are mixed. Existing studies have exploited variation in parental age across families, which is problematic because families differ not only in parental age but also in genetic and environmental factors. To isolate the effects of parental age, holding many genetic and environmental factors constant, we exploit the variation in parental age within families and compare outcomes for full siblings. The study data were retrieved from the Medical Birth Registry of Norway, which covers the entire population of births in Norway over an extended period (totaling 1.2 million births). Using variation in parental age when siblings were born, we find large and convex effects of increased parental age on the increased risk of birth disorders. To facilitate comparison with the existing literature, we also estimate the effects of parental age using variation in parental age across families and find that the effects are substantially weaker. We conclude that the existing literature may have underestimated the negative effects of parental aging on adverse offspring outcomes.
Adapting and validating the Autism Diagnostic Observation Schedule Version 2 for use with deaf children and young people
Authors: Phillips Helen , Wright Barry , Allgar Victoria , McConachie Helen , Sweetman Jennifer , Hargate Rebecca , Hodkinson Rachel , Bland Martin , George Hannah , Hughes Anna , Hayward Emily , De Las Heras Victoria Fernandez Garcia , Le Couteur Ann 
Published: March 2021

AbstractWe report a Delphi Consensus modification and first validation study of the Autism Diagnostic Observation Schedule – 2 with deaf children and young people (ADOS-2 Deaf adaptation). Validation included 122 deaf participants (aged 2–18 years), 63 with an Autism Spectrum Disorder (ASD). This was compared to a National Institute for Health and Clinical Excellence (NICE) guideline standard clinical assessment by blinded independent specialist clinicians. Results showed overall sensitivity 73% (95%CI 60%, 83%); specificity 71% (95%CI 58%, 82%), and for the more common modules 1–3 (combined as in previous studies) sensitivity 79% (95% CI 65–89%); specificity 79% (95% CI 66–89%) suggesting this instrument will be a helpful addition for use with deaf children and young people.
Re-approaching Celts: Origins, Society, and Social Change
Authors: Pope Rachel 
Published: March 2021

AbstractThis work re-approaches the origins of “the Celts” by detailing the character of their society and the nature of social change in Europe across 700–300 BC. A new approach integrates regional burial archaeology with contemporary classical texts to further refine our social understanding of the European Iron Age. Those known to us as “Celts” were matrifocal Early Iron Age groups in central Gaul who engaged in social traditions out of the central European salt trade and became heavily involved in Mediterranean politics. The paper focuses on evidence from the Hallstatt–La Tène transition to solve a 150-year-old problem: how the Early Iron Age “Celts” became the early La Tène “Galatai,” who engaged in the Celtic migrations and the sacking of Rome at 387 BC.
Colonisation of secondary habitats in mining sites by Labidura riparia (Dermaptera: Labiduridae) from multiple natural source populations
Authors: Gueth Mareike , Wiegleb Gerhard , Durka Walter 
Published: March 2021

AbstractBackgroundOpen cast lignite mines, sand pits and military training areas represent human-made, secondary habitats for specialized xerothermophilous and psammophilous species. Rare species, including the earwigLabidurariparia,are found in high population densities in such sites. However, it is unknown from which sources colonisation took place and how genetic variation compares to that of ancient populations on natural sites.MethodsUsing nine microsatellite markers, we analysed genetic variation and population structure ofL. ripariain 21 populations in NE Germany both from secondary habitats such as lignite-mining sites, military training areas and a potassium mining heap, and rare primary habitats, such as coastal and inland dunes.ResultsGenetic variation was higher in populations from post-mining sites and former military training areas than in populations from coastal or inland dune sites. Overall population differentiation was substantial (FST = 0.08;FʹST = 0.253), with stronger differentiation among primary (FST = 0.196;FʹST = 0.473) than among secondary habitats (FST = 0.043;FʹST = 0.147). Differentiation followed a pattern of isolation by distance. Bayesian structure analysis revealed three gene pools representing primary habitats on a coastal dune and two different inland dunes. All populations from secondary habitats were mixtures of the two inland dune gene pools, suggesting multiple colonization of post-mining areas from different source populations and hybridisation among source populations.DiscussionPopulations ofL. ripariafrom primary habitats deserve special conservation, because they harbour differentiated gene pools. The majority of theL. ripariapopulations, however, thrive in secondary habitats, highlighting their role for conservation.Implications for insect conservationA dual strategy should be followed of conserving both remaining natural habitat harbouring particular intraspecific gene pools and secondary habitat inhabited by large admixed and genetically highly variable populations.
Emissions of biogenic volatile organic compounds (BVOCs) from the rhizosphere of Scots pine (Pinus sylvestris) seedlings exposed to warming, moderate N addition and bark herbivory by large pine weevil (Hylobius abietis)
Authors: Rasheed Muhammad Usman , Kivimäenpää M. , Kasurinen A. 
Published: March 2021

Abstract
Aims
Biogenic volatile organic compound (BVOC) research has been mostly focused on foliar emissions. In this experiment, the main focus was on rhizosphere BVOC emissions of Scots pine seedlings under changing growth conditions.

Methods
Soil-growing Scots pines were exposed to increased air (0.5°C) and soil (4.0°C) temperature and N addition (30 kg N ha− 1 yr− 1) for three growing seasons in a field experiment. In addition to these factors, seedlings were exposed to bark herbivory by large pine weevils in two last seasons. Gas-chromatography and mass-spectrometry was used for analyzing the BVOC samples collected from pine rhizosphere.

Results
Almost 98 % of BVOCs were non-oxygenated monoterpenes (nMTs), 1 % oxygenated monoterpenes (oMTs), 0.5 % sesquiterpenes (SQTs), and 1 % other BVOCs. In both years, there was an interaction of warming, N addition and bark herbivory on rhizosphere BVOC emissions. In 2015, warming and N addition in single exposures decreased oMT emissions, while herbivory in single exposure increased oMT emissions. In 2016, the three-way interaction showed that the effects of warming, N addition and herbivory on BVOCs were mainly detected in single exposures. In 2016, warming decreased nMT, oMT, SQT and other BVOC emissions; N addition decreased oMT and SQT emissions; and herbivory decreased SQT and other BVOC emissions.

Conclusions
Warming and N addition in single exposures decreased the rhizosphere BVOC emissions. The effect of bark herbivory on BVOC emissions varied between the years from increase to decrease. It seems that under altered growth conditions Scots pine seedlings may reduce carbon investment to rhizosphere BVOCs.
Does Radical-Right Success Make the Political Debate More Negative? Evidence from Emotional Rhetoric in German State Parliaments
Authors: Valentim Vicente , Widmann Tobias 
Published: March 2021

AbstractPolitical rhetoric has important effects on the quality of democracy, but we know very little about what causes variation in the tone of the political debate. We investigate how radical-right success affects the way the remaining politicians discuss political issues. Using an original dictionary, we measure different positive and negative emotions in a newly collected dataset of speeches in German state parliaments. Taking advantage of variation in the timing of elections when radical-right politicians enter these parliaments, we find that politicians of other parties respond to radical-right success by using more positive, instead of negative, emotions. The analyses suggest that this finding may be the result of a strategy by the remaining politicians to distance themselves from radical-right discourse. Our findings highlight how radical-right success can create incentives for other politicians to enforce democratic norms that radical-right politicians breach.
Pre-surgery planning tool for estimation of resection volume to improve nasal breathing based on lattice Boltzmann fluid flow simulations
Authors: Berger M. , Pillei M. , Giotakis A. , Mehrle A. , Recheis W. , Kral F. , Kraxner M. , Riechelmann H. , Freysinger W. 
Published: March 2021

Abstract
Purpose
State-of-the-art medical examination techniques (e.g., rhinomanometry and endoscopy) do not always lead to satisfactory postoperative outcome. A fully automatized optimization tool based on patient computer tomography (CT) data to calculate local pressure gradient regions to reshape pathological nasal cavity geometry is proposed.

Methods
Five anonymous pre- and postoperative CT datasets with nasal septum deviations were used to simulate the airflow through the nasal cavity with lattice Boltzmann (LB) simulations. Pressure gradient regions were detected by a streamline analysis. After shape optimization, the volumetric difference between the two shapes of the nasal cavity yields the estimated resection volume.

Results
At LB rhinomanometry boundary conditions (bilateral flow rate of 600 ml/s), the preliminary study shows a critical pressure gradient of −1.1 Pa/mm as optimization criterion. The maximum coronal airflow ΔA := cross-section ratio $$\frac{\mathrm{virtual surgery }}{\mathrm{post}-\mathrm{surgery}}$$

virtual
surgery

post
-
surgery

found close to the nostrils is 1.15. For the patients a pressure drop ratio ΔΠ := (pre-surgery − virtual surgery)/(pre-surgery − post-surgery) between nostril and nasopharynx of 1.25, 1.72, −1.85, 0.79 and 1.02 is calculated.

Conclusions
LB fluid mechanics optimization of the nasal cavity can yield results similar to surgery for air-flow cross section and pressure drop between nostril and nasopharynx. The optimization is numerically stable in all five cases of the presented study. A limitation of this study is that anatomical constraints (e.g. mucosa) have not been considered.
Treatment Strategies of Gastric Cancer—Molecular Targets for Anti-angiogenic Therapy: a State-of-the-art Review
Authors: Tyczyńska Magdalena , Kędzierawski Paweł , Karakuła Kaja , Januszewski Jacek , Kozak Krzysztof , Sitarz Monika , Forma Alicja 
Published: March 2021

Abstract
Purpose
Recent studies have suggested that molecular targets for the anti-angiogenic therapy might constitute a basis for additional therapy in gastric cancer treatment. A vast number of molecules, receptors, pathways, specific interactions, and thus strategies that target gastric cancer angiogenesis specifically have been reported in numerous research articles and clinical trials.

Methods
We conducted a systematic literature review of molecularly targeted treatment strategies in gastric cancer on the following databases—PubMed, Google Scholar, and Scopus—on September 20, 2020. Multiple articles and evaluations were searched for studies reporting newly found and promising molecular anti-angiogenic therapy pathways. Eventually, 39 articles regarding the anti-angiogenic therapy in gastric cancer were included in the final analysis.

Results
As a consequence of the release of the pro-angiogenic molecules from the tumour cells, gastric cancer presents high angiogenic capability. Therefore, potential schemes for future treatment strategies include the decrease of the process ligands as well as the expression of their receptors. Moreover, the increase in the angiogenic inhibitor levels and direct aim for the inner walls of the endothelial cells appear as a promising therapeutic strategy. Beyond that, angiogenesis process inhibition seems to indirectly exaggerate the effects of chemotherapy in the considered patients.

Conclusions
The anti-angiogenic treatment in gastric cancer patients evaluates its significance especially in the early stages of the malignancy. The studies conducted so far show that most of the meaningful angiogenic factors and receptors with the potential molecular pathways should be further evaluated since they could potentially play a substantial role in future therapies.
High-Skilled vs. Low-Skilled Migrant Women: the Use of Competencies and Knowledge—Theoretical and Political Implications: an Example of the Elderly Care Sector in Poland
Authors: Kubiciel-Lodzińska Sabina , Maj Jolanta 
Published: March 2021

AbstractThis paper presents the influx of migrants into the elderly care sector in Poland, which, until recently, has been perceived as a country that “exports” caregivers. It describes the results of 31 individual in-depth interviews conducted with immigrant women who take care of elderly in Poland. The purpose of the study was to determine the profile of an immigrant taking up work in the elderly care sector, including the specification of their education level and competencies. It was determined that 55% of the respondents have higher education, including over 20% with a degree in nursing or physiotherapeutic education. It was established that, when analysing migrants in the care sector, it seems necessary not to divide migrants based on their education level (high- vs. low-skilled), but rather to consider the education profile as a whole (general and special profile education). Women with specialised education differ from the other migrants in regard to their better labour market position (higher remuneration, legal employment) and the scope of skill usage. The comparison of high-skilled and low-skilled workers in the care sector is very useful from the perspective of policymakers due to the fact that there is an issue of over-qualification in Poland. The article contributes to the literature, especially research dealing with brain waste, as there is theoretical and empirical gap in research on the differences between high-skilled and low-skilled migrants working in elderly care.