bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peroxisomal support of mitochondrial respiratory efficiency promotes ER stress survival
Authors: Hijazi Imadeddin , Wang Emily , Orozco Michelle , Pelton Sarah , Chang Amy 
Published: December 2021

ABSTRACT
Endoplasmic reticulum stress (ERS) occurs when cellular demand for protein folding exceeds the capacity of the organelle. Adaptation and cell survival in response to ERS requires a critical contribution by mitochondria and peroxisomes. During ERS responses, mitochondrial respiration increases to ameliorate reactive oxygen species (ROS) accumulation. We now show in yeast that peroxisome abundance also increases to promote an adaptive response. In pox1Δ cells, which are defective in peroxisomal β-oxidation of fatty acids, the respiratory response to ERS is impaired and ROS accrues. However, the respiratory response to ERS is rescued and ROS production is mitigated in pox1Δ cells overexpressing Mpc1, the mitochondrial pyruvate carrier that provides another source of acetyl CoA to fuel the tricarboxylic acid cycle and oxidative phosphorylation. Using proteomics, select mitochondrial proteins were identified that undergo upregulation upon ERS to remodel the respiratory machinery. The abundance of several peroxisome-based proteins was also increased, corroborating the role of peroxisomes in ERS adaptation. Finally, ERS stimulates assembly of respiratory complexes into higher-order supercomplexes, underlying increased electron transfer efficiency. Our results highlight peroxisomal and mitochondrial support for ERS adaptation to favor cell survival.
Nutritional symbionts enhance structural defence against predation and fungal infection in a grain pest beetle
Authors: Kanyile Sthandiwe Nomthandazo , Engl Tobias , Kaltenpoth Martin 
Published: December 2021

ABSTRACT
Many insects benefit from bacterial symbionts that provide essential nutrients and thereby extend the hosts’ adaptive potential and their ability to cope with challenging environments. However, the implications of nutritional symbioses for the hosts’ defence against natural enemies remain largely unstudied. Here, we investigated whether the cuticle-enhancing nutritional symbiosis of the saw-toothed grain beetle Oryzaephilus surinamensis confers protection against predation and fungal infection. We exposed age-defined symbiotic and symbiont-depleted (aposymbiotic) beetles to two antagonists that must actively penetrate the cuticle for a successful attack: wolf spiders (Lycosidae) and the fungal entomopathogen Beauveria bassiana. While young beetles suffered from high predation and fungal infection rates regardless of symbiont presence, symbiotic beetles were able to escape this period of vulnerability and reach high survival probabilities significantly faster than aposymbiotic beetles. To understand the mechanistic basis of these differences, we conducted a time-series analysis of cuticle development in symbiotic and aposymbiotic beetles by measuring cuticular melanisation and thickness. The results reveal that the symbionts accelerate their host's cuticle formation and thereby enable it to quickly reach a cuticle quality threshold that confers structural protection against predation and fungal infection. Considering the widespread occurrence of cuticle enhancement via symbiont-mediated tyrosine supplementation in beetles and other insects, our findings demonstrate how nutritional symbioses can have important ecological implications reaching beyond the immediate nutrient-provisioning benefits.
The Unintended Consequence of Land Finance: Evidence from Corporate Tax Avoidance
Authors: Chen Tao , Tan Youchao , Wang Jinghua , Zeng Cheng (Colin) 
Published: December 2021

Using a large sample of unlisted industrial firms in China, we find that a decrease in local governments’ land transfer revenues leads to lower tax avoidance by firms within their jurisdiction. Our cross-sectional variation tests suggest that the tax-avoidance-reduction effect is stronger in cities with higher land finance dependence and government intervention, as well as where the political leaders have stronger promotion incentives. However, the effect is moderated for politically connected firms. Further analysis reveals that intensified tax enforcement is the mechanism through which land transfer revenue losses result in decreased tax avoidance. Our study offers novel evidence on a previously underexplored determinant of corporate tax avoidance through the lens of land finance.This paper was accepted by Gustavo Manso, finance.Funding: The authors acknowledge financial support from the National Natural Science Foundation of China [Grants 72002105, 71972089 and 72132002]. T. Chen is grateful for the financial support from the Singapore Ministry of Education Academic Research Fund [Grant 2015-T2-1-118, RG166/18] and the Natural Science Foundation of Guangdong Province, China [Grants 2018A03031043 and 2019A1515011635]. C. (C.) Zeng acknowledges the start-up research fund from the Hong Kong Polytechnic University [Grant A0035237].Supplemental Material: Data and the online appendix are available at https://doi.org/10.1287/mnsc.2021.4191 .
The impact of walker height positions and their influence on triceps activity and energy conservation: a pilot study
Authors: Rzepkowski Terry , Abrams Saige C , Bell Farrah P , Orkwis Alexander , Radin Hunter , Reinoso Gustavo 
Published: December 2021

Background/Aims Millions of adults use walkers for functional mobility. Inappropriate walker use is associated with incorrect height, forward-leaning posture, and increased energy expenditure. Few studies have investigated the impact of walker positions and their influence on triceps activity. The present study assessed walker height and baseline positioning for individuals with a 50% weight bearing restriction of the lower extremity, and implications for energy conservation. Methods A total of 38 young adults (mean age = 24.95 years; 84.2% female; 15.8% male) participated in this study with a two-wheeled walker. Participants executed five walker positions while maintaining 50% weight bearing of the lower extremity to determine the effect on triceps electromyography activity. Results Triceps electromyography activity did significantly change across the five walker positions assessed (X2 [df=37, P<0.001]). This study showed that the median electromyography activity for positions B (median=0.268) and A (median=0.280) was significantly less than the median electromyography activity for position E (median=0.452; P<0.001). The effect sizes for comparisons of positions B and E (r=0.49) as well as A and E were the largest (r=0.53). Conclusions These findings suggest an elbow angle of 26–35° (position B), followed by an elbow angle of 15–25° (position A), with the walker in line with the heels of the participant, to be superior in minimising exertion of the triceps.
Changes in prevalence and risk factors of hypertension among adults in Bangladesh: An analysis of two waves of nationally representative surveys
Authors: Chowdhury Muhammad Abdul Baker , Islam Mirajul , Rahman Jakia , Uddin Mohammed Taj , Haque Md Rabiul , Uddin Md Jamal 
Published: December 2021

Introduction
Bangladesh is one of the countries where the prevalence of non-communicable diseases (NCDs) such as hypertension is rising due to rising living standards, sedentary lifestyles, and epidemiological transition. Among the NCDs, hypertension is a major risk factor for CVD, accounting for half of all coronary heart disease worldwide. However, detailed research in this area has been limited in Bangladesh. The objective of the study was to estimate changes in the prevalence and risk factors of hypertension among Bangladeshi adult population. The study also sought to identify socioeconomic status-related inequality of hypertension prevalence in Bangladesh.

Methods
Cross-sectional analysis was conducted using nationally representative two waves of the Bangladesh Demographic and Health Survey (BDHS) in 2011 and 2017–18. Survey participants were adults 18 years or older- which included detailed biomarker and anthropometric measurements of 23539 participants. The change in prevalence of hypertension was estimated, and adjusted odds ratios were obtained using multivariable survey logistic regression models. Further, Wagstaff decomposition method was also used to analyze the relative contributions of factors to hypertension.

Results
From 2011 to 2018, the hypertension prevalence among adults aged ≥35 years increased from 25.84% to 39.40% (p<0.001), with the largest relative increase (97%) among obese individuals. The prevalence among women remained higher than men whereas the relative increase among men and women were 75% and 39%, respectively. Regression analysis identified age and BMI as the independent risk factors of hypertension. Other risk factors of hypertension were sex, marital status, education, geographic region, wealth index, and diabetes status in both survey years. Female adults had significantly higher hypertension risk in both survey years in the overall analysis in, however, in the subgroup analysis, the gender difference in hypertension risk was not significant in rural 2011 and urban 2018 samples. Decomposition analysis revealed that the contributions of socio-economic status related inequality of hypertension in 2011 were46.58% and 20.85% for wealth index and BMI, respectively. However, the contributions of wealth index and BMI have shifted to 12.60% and 55.29%, respectively in 2018.

Conclusion
The prevalence of hypertension among Bangladeshi adults has increased significantly, and there is no subgroup where it is decreasing. Population-level approaches directed at high-risk groups (overweight, obese) should be implemented thoroughly. We underscore prevention strategies by following strong collaboration with stakeholders in the health system of the country to adopt healthy lifestyle choices.
Parkinson’s patients situation during the SARS CoV-2 pandemic and their interest in telemedicine A cross-sectional study
Authors: Witt Victoria Dorothea , Baur Gabriel , Ecke Jule , Kirchner Anja , Hauptmann Björn 
Published: December 2021

BackgroundDuring the SARS CoV-2 pandemic, telemedicine experienced an enormous boom. Also, for Parkinson’s patients there are upcoming alternatives to regular care.ObjectiveThe aim of the present study was to interview Parkinson’s patients under the impression of the first lockdown in Germany about their health care situation, but especially about the use of and attitudes towards videotherapy and -consultation.MethodsNorthern German members of the German Parkinson Association were mailed a 16-item questionnaire including demographic questions on a one-time basis. The voluntary participants answered regarding their health care situation during the first German SARS CoV-2 lockdown, as well as attitudes towards videotherapy/-consultations.ResultsThe 332 (of 974 questionnaires) responding evaluated their care situation predominantly (58.7%) unchanged during lockdown. There was hardly any previous experience in the areas of videotherapy and -consultations (15.4% and 3%, respectively), but at the same time mostly imaginability of implementation (54.2% and 56%, respectively) and the belief that they could motivate themselves to do so (51.8%). A total of 69% welcomed technical support for the implementation of videotherapy.ConclusionIn principle, there seems to be both, a need and an interest in telematics in healthcare such as videotherapy and video consultations, even if further barriers such as technical implementation need to be addressed. An expansion of telemedical services and infrastructure seems desirable not only in the pandemic situation, but also in the long term against the backdrop of demographic change, especially in an area like Schleswig-Holstein. Further studies are needed.
Influenza vaccination coverage and factors associated with severe laboratory-confirmed influenza-related illness in patients receiving care at a tertiary hospital in Catalonia (Spain) during the 2018–2019 epidemic season
Authors: Mena Guillermo , Casas Irma , Casañ Cristina , Auñón Mario , Matas Lurdes , Mòdol Josep-Maria , Esteve María 
Published: December 2021

Introduction
Influenza vaccination rates in risk groups remain suboptimal. Evidence supporting a significant association between influenza vaccination and severe illness is limited.

Methods
We retrospectively analyzed the epidemiological characteristics of out- and inpatients with laboratory-confirmed influenza infection attended during the 2018–19 epidemic season. Influenza vaccination coverage by indication was analyzed. Logistic regression was used to compare the odds of vaccination between severe and non-severe influenza-positive patients. Severe cases were defined as presenting pneumonia, admission to critical care units and/or death.

Results
The overall vaccination coverage among influenza-positive patients was 30.4%. In subjects with ≥ 1 indication for vaccination, the vaccination coverage was 42.4%. By indication, coverage rates were: 52.5% in patients aged ≥ 59 years, 42.2% in obese patients, 29.2% in immunosuppressed subjects and 6.5% in pregnant women. In patients with underlying chronic diseases, a higher coverage was found in patients with cognitive impairment (77%), muscular dystrophy (63.6%) and renal disease (60.4%). The multivariate logistic regression model showed severe influenza-related illness was associated with a lack of influenza vaccination before seeking care during the 2018–2019 season [0.59 (95%CI 0.36–0.97); p = 0.038], older age [1.01 (95%CI 1.00–1.02); p = 0.009] and current or former smoking status [1.63 (95%CI 0.84–3.18) and 2.03 (95%CI 1.16–3.57); p = 0.031], adjusted by underlying disease.

Conclusion
Adjusting by age, smoking status and underlying disease, a moderate association between the influenza vaccine and severe laboratory-confirmed influenza-related illness was found in an epidemic season in which there was matching between the vaccine and circulating strains. Protection against complications, especially in older subjects and in those with underlying disease is postulated as one of the strengths of annual influenza vaccination. However, influenza vaccination is a pending issue in these groups, especially in pregnant women and obese people. To avoid suboptimal vaccination coverages, health professionals should recommend the seasonal influenza vaccination according to the annual instructions of the health authorities.
Experiences of women with Zika virus (ZIKV) versus the provision of health services in two cities in Colombia: A qualitative study
Authors: Ocampo Cañas Jovana Alexandra , Pinilla Alfonso Maria Janeth , Navarro Plazas Clemencia del Pilar , Mejia Arbelaez Carlos Mauricio , Patiño Rueda Jhon Sebastián 
Published: December 2021

Background
In February 2016, the World Health Organization (WHO) declared the epidemic of the ZIKA virus (ZIKV) in Latin America to be a public health emergency. In Colombia, 11,944 pregnant women registered a ZIKV infection during the epidemic. So far, little is known about the experiences of women infected with ZIKV during their pregnancy, especially those relating to the provision of health services during the period of the epidemic.

Objective
To explore the experiences of pregnant women diagnosed with ZIKV infection about the provision of health services in two Colombian cities, considering the perspective of sexual and reproductive rights.

Methods
Qualitative study under the grounded theory approach, which uses semi-structured interviews as tools to explore the biographical experience of mothers during their gestation process and ZIKV infection, dividing the interview into two broad categories: before and during pregnancy.

Results
Twenty-two women were interviewed, 10 in Cali and 12 in Villavicencio. The average age at the time of pregnancy was 27.6 years. Most women were not planning at the time of pregnancy and the pregnancy was unwanted. Most campaigns focused on mosquito eradication rather than on sexual and reproductive health campaigns. The quality of health care was not sufficient, adequate, or appropriate. Also, the breakdown of the health system to deal with the pandemic was also noted. Some women were treated with disrespect by health professionals. Voluntary termination of pregnancy was inadequately advised, and women lost autonomy regarding decisions about their health.

Conclusions
In the health care of ZIKV epidemics, it is necessary to include the gender perspective, more specifically, sexual and reproductive rights. In addition, these epidemics must be addressed through a comprehensive, appropriate, and not fragmented health system, in which sexual and reproductive rights must be mainstreamed in all health promotion and prevention programs.
Platelet count/spleen volume ratio has a good predictive value for esophageal varices in patients with hepatitis B liver cirrhosis
Authors: Yu Sihao , Chen Wei , Jiang Zicheng 
Published: December 2021

Background & aims
Platelet count/spleen longest diameter ratio (PSDR) is widely used in clinical practice due to its good performance in predicting esophageal varices (EV). We obtained spleen volume (SV) by magnetic resonance examination, the purpose of this study was to evaluate the clinical value of platelet count/spleen volume ratio (PSVR) and spleen volume in predicting EV in patients with hepatitis B cirrhosis. Methods: This study was a diagnostic accuracy experiment and retrospective, 199 patients with hepatitis B cirrhosis who met the criteria were selected as the research subjects. All patients were collected blood samples in the morning on an empty stomach within 2 days, and related indicators were tested. Within 10 days, they received electronic gastroscopy and abdominal magnetic resonance examination. According to the Child-Pugh score, the patients were divided into groups with or without EV and with or without high-risk esophageal varices (HRV), then statistical analysis of the two groups was performed.

Results
The area under the curve (AUC) of PSVR in predicting EV or HRV in each group (85.5%-92.6%) was higher than PSDR, SV, spleen diameter, and platelet count. The AUC of PSDR in diagnosing HRV was higher than SV, and the AUC of SV in diagnosing EV was higher than PSDR, but the difference was not significant (P>0.05). In Child-Pugh A patients, Multivariate logistic regression analysis showed PSVR could be a predictor of HRV (P<0.05), SV was a reliable predictor of EV (P<0.05).

Conclusion
PSVR is better than PSDR, spleen diameter, platelet count in predicting EV; in the absence of serological results, SV could be used instead of PSDR. Both can predict EV or HRV of patients with hepatitis B cirrhosis.
Three weeks of a home-based “sleep low-train low” intervention improves functional threshold power in trained cyclists: A feasibility study
Authors: Bennett Samuel , Tiollier Eve , Brocherie Franck , Owens Daniel J. , Morton James P. , Louis Julien 
Published: December 2021

Background
“Sleep Low-Train Low” is a training-nutrition strategy intended to purposefully reduce muscle glycogen availability around specific exercise sessions, potentially amplifying the training stimulus via augmented cell signalling. The aim of this study was to assess the feasibility of a 3-week home-based “sleep low-train low” programme and its effects on cycling performance in trained athletes.

Methods
Fifty-five trained athletes (Functional Threshold Power [FTP]: 258 ± 52W) completed a home-based cycling training program consisting of evening high-intensity training (6 × 5 min at 105% FTP), followed by low-intensity training (1 hr at 75% FTP) the next morning, three times weekly for three consecutive weeks. Participant’s daily carbohydrate (CHO) intake (6 g·kg-1·d-1) was matched but timed differently to manipulate CHO availability around exercise: no CHO consumption post- HIT until post-LIT sessions [Sleep Low (SL), n = 28] or CHO consumption evenly distributed throughout the day [Control (CON), n = 27]. Sessions were monitored remotely via power data uploaded to an online training platform, with performance tests conducted pre-, post-intervention.

Results
LIT exercise intensity reduced by 3% across week 1, 3 and 2% in week 2 (P < 0.01) with elevated RPE in SL vs. CON (P < 0.01). SL enhanced FTP by +5.5% vs. +1.2% in CON (P < 0.01). Comparable increases in 5-min peak power output (PPO) were observed between groups (P < 0.01) with +2.3% and +2.7% in SL and CON, respectively (P = 0.77). SL 1-min PPO was unchanged (+0.8%) whilst CON improved by +3.9% (P = 0.0144).

Conclusion
Despite reduced relative training intensity, our data demonstrate short-term “sleep low-train low” intervention improves FTP compared with typically “normal” CHO availability during exercise. Importantly, training was completed unsupervised at home (during the COVID-19 pandemic), thus demonstrating the feasibility of completing a “sleep low-train low” protocol under non-laboratory conditions.
When Rural and Urban Become “Us” versus “Them”: How a Growing Divide is Reshaping American Politics
Authors: Brown Trevor , Mettler Suzanne , Puzzi Samantha 
Published: December 2021

Abstract
The United States’ long-standing broad “catch-all” political parties have historically combined voters from distinct regions of the country, each including both rural and urban dwellers. Since the late 1990s, however, rural Americans nationwide have increasingly supported the Republican Party, while urbanites have persisted in their allegiance to the Democratic Party. The growing rural-urban divide has become mapped onto American polarization in ways that are fostering tribalism. This place-based cleavage is now contributing to the transformation of the nation’s politics and that of many states. It also threatens to have deleterious effects on democracy.
Improved gas sand facies classification and enhanced reservoir description based on calibrated rock physics modelling: A case study
Authors: Shakir Urooj , Ali Aamir , Amjad Muhammad Raiees , Hussain Muyyassar 
Published: December 2021

Abstract
Rock physics provides a dynamic tool for quantitative analysis by developing the basic relationship between fluid, lithological, and depositional environment of the reservoir. The elastic attributes such as impedance, density, velocity, V
p/V
s ratio, Mu-rho, and Lambda-rho are crucial parameters to characterize reservoir and non-reservoir facies. Rock physics modelling assists like a bridge to link the elastic properties to petrophysical properties such as porosity, facies distribution, fluid saturation, and clay/shale volume. A robust petro-elastic relationship obtained from rock physics models leads to more precise discrimination of pay and non-pay facies in the sand intervals of the study area. The Paleocene aged Lower Ranikot Formation and Pab sandstone of Cretaceous age are proven reservoirs of the Mehar gas field, Lower Indus Basin. These sands are widely distributed in the southwestern part of the basin and are enormously heterogeneous, which makes it difficult to distinguish facies and fluid content in the reservoir intervals. So, an attempt is made in this paper to separate the reservoir facies from non-reservoir facies by using an integrated approach of the petro-elastic domain in the targeted sand intervals. Furthermore, missing logs (S-sonic and P-sonic) were also synthesized in the wells and missing intervals along with improving the poor quality of the density log by captivating the washouts and other side effects. The calibrated rock physics model shows good consistency between measured and modelled logs. Petro-elastic models were predicted initially using petrophysical properties and incorporated at true reservoir conditions/parameters. Lithofacies were defined based on petrophysical cut-offs. Rock physics modelled elastic properties (Lambda-rho versus Mu-rho, impedance versus V
p/V
s ratio) were then cross-plotted by keeping lithofacies in the Z-axis. The cross-plots clearly separated and demarcated the litho-fluid classes (wet sand, gas sand, shale, and limestone) with specific orientation/patterns which were randomized in conventional petrophysical analysis.