bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dairy Intake in Association with Asthma Symptoms Among a Large Sample of Children and Adolescents: A Cross-Sectional Study
Authors: Jamalvandi Mona , Sasanfar Bahareh , Nafei Zahra , Behniafard Nasrin , Jafari Marjan , Salehi-Abargouei Amin 
Published: December 2021

Abstract
Dairy products may be linked to an increased risk of asthma, although there is little scientific evidence to back this up. The goal of this study was to look at the link between dairy consumption and asthma symptoms. This cross-sectional study was conducted on children and adolescents aged 6-8 and 13-14 living in central Iran. Dietary food consumption was assessed using a multiple-choice questionnaire. Logistic regression was used to obtain odds ratios for the association between milk, other dairy products, and total dairy consumption with asthma symptoms. In total, 7667 participants (3414 boys and 4253 girls) were included in the current study. Milk intake and total dairy consumption were not associated with the likelihood of wheezing, asthma confirmed by a doctor, current asthma, and asthma medication use. However, the analysis revealed that those who eat other dairy products on most days or every day might have a reduced likelihood of wheezing compared to those who do not eat or rarely eat other dairy products (OR: 0.65, 95% CI 0.44-0.94, Pterend=0.18). After adjusting for age, sex (OR: 0.58, 95% CI 0.39-0.84, Pterend=0.03), and additionally adjusting for watching TV and computer use (OR=0.58, 0.40-0.85, Pterend=0.02), and BMI (OR: 0.58, 95% CI 0.40-0.85, Pterend=0.02), individuals in the highest category of other dairy consumption had significantly lower odds of wheezing compared with those with the lowest intakes. In conclusion, the consumption of dairy products other than milk, including cheese and yogurt, might reduce the likelihood of wheezing in children and adolescents.
Monitoring Drug-Target Interactions through Target Engagement-Mediated Amplification on Arrays and in situ
Authors: Al-Amin Rasel , Johansson Lars , Abdurakhmanov Eldar , Landegren Nils , Löf Liza , Arngården Linda , Blokzijl Andries , Svensson Richard , Hammond Maria , Lönn Peter , Haybaeck Johannes , Kamali-Moghaddam Masood , Jensen Annika , Danielson U Helena , Artursson Per , Lundbäck Thomas , Landegren Ulf 
Published: December 2021

Abstract
Drugs are designed to bind their target proteins in physiologically relevant tissues and organs to modulate biological functions and elicit desirable clinical outcomes. Information about target engagement at cellular and subcellular resolution is therefore critical for guiding compound optimization in drug discovery, and for probing resistance mechanisms to targeted therapies in clinical samples. We describe a target engagement-mediated amplification (TEMA) technology, where oligonucleotide-conjugated drugs are used to visualize and measure target engagement in situ, amplified via rolling-circle replication of circularized oligonucleotide probes. We illustrate the TEMA technique using dasatinib and gefitinib, two kinase inhibitors with distinct selectivity profiles. In vitro binding by dasatinib probe to arrays of displayed proteins accurately reproduced known selectivity profiles, while their differential binding to a panel of fixed adherent cells agreed with expectations from expression profiles of the cells. These findings were corroborated by competition experiments using kinase inhibitors with overlapping and non-overlapping target specificities, and translated to pathology tissue sections. We also introduce a proximity ligation variant of TEMA in which these drug-DNA conjugates are combined with antibody-DNA conjugates to selectively investigate binding to specific target proteins of interest. This form of the assay serves to improve resolution of binding to on- and off-target proteins. In conclusion, TEMA has the potential to aid in drug development and clinical routine by conferring valuable insights in drug-target interactions at spatial resolution in protein arrays, cells and tissues.
Decision Making for Anti-VEGF Inhibitor Continuation: Dip Stick? or Urine Protein/Creatinine Ratio? (VERSiON UP Study)
Authors: Nakamura Michio , Funakoshi Taro , Kataoka Shigeki , Horimatsu Takahiro , Nishikawa Yoshitaka , Matsubara Takeshi , Mizukami Takuro , Goto Tomoyuki , Tsuchihashi Kenji , Baba Eishi , Tsumura Takehiko , Mihara Yoshiaki , Hamaguchi Tetsuya , Yanagita Motoko , Muto Manabu 
Published: December 2021

Abstract
Background: Monitoring proteinuria is important for the management of patients with cancer treated with anti-vascular endothelial growth factor (VEGF) or anti-VEGF receptor (VEGFR) inhibitors (VEGF/Ri). Here we investigated the difference between the urine protein/creatinine ratio (UPCR) and a qualitative value test (QV) on the decision making of treatment continuation and the usefulness of UPCR testing in patients with gastrointestinal cancer treated with anti-VEGF/Ri.Methods: From January 2017 to December 2018, a survey was conducted based on the medical records of patients with gastrointestinal cancer with a QV of ≥ 2+ during the use of anti-VEGF/Ri at seven Japanese institutions participating in the Onco-nephrology Consortium. The primary endpoint was the ratio of the worst UPCR < 2.0 (low UPCR) in cases with a QV2+ at the point of the first proteinuria onset. The secondary endpoints were a comparison of low UPCR and worst UPCR ≥ 2.0 (high UPCR), the concordance rate between UPCR and QV in the Common Terminology Criteria for Adverse Events (CTCAE) grading, and the differences in the decision making for anti-VEGF/Ri continuation.Results: Among the 71 patients enrolled, the proportion of low UPCR in onset QV2+ (n = 53) was 66% (n = 35). In a comparison between low (n=36) and high UPCR cases (n = 24), body weight (P = 0.036), onset QV status (P = 0.0134), and worst QV status (P < 0.0001) were significantly associated with UPCR levels. The concordance rate for CTCAE Grade 2 of both the QV and UPCR was 83%. Regarding the judgment of anti-VEGF/Ri continuation, treatment was continued in 42.4% of cases when the QV became 3+, whereas only 25% continued treatment when the UPCR value became high.Conclusion: Urine dipstick test results may overestimate proteinuria, and the UPCR result tended to be more critical than the QV when deciding the treatment policy.Trial registration: This study is a multiple institutional retrospectively registered observational trial. Clinical Trial number: University Hospital Medical Information Network (UMIN) Clinical Trials Registry (protocol ID UMIN000042545)
Incidence And Risk Factors For Postoperative Pneumonia Following Surgically Treated Hip Fracture In Geriatric Patients: A Retrospective Cohort Study
Authors: Tian Yunxu , Zhu Yanbin , Zhang Kexin , Tian Miao , Qin Shuhui , Li Xiuting , Zhang Yingze 
Published: December 2021

Abstract
Objective: Large sample investigations for risk factors for pneumonia in elderly patients after hip fracture surgeries are lacking. The purpose of this study is to determine the incidence and risk factors for postoperative pneumonia in geriatric patients following hip fracture operations.Methods: A retrospective study of incidence and risk factors in a tertiary referral center between 2016 and 2020 was conducted. Geriatric patients who developed postoperative pneumonia after surgeries of hip fracture during hospitalization stay were defined as cases and those without as controls. Multivariate logistic regression model was used to evaluate risk factors for postoperative pneumonia.Results: This study included 3147 patients, and 182 developed postoperative pneumonia, denoting the rate of 5.7%. In the multivariate analyses, age (OR, 1.04; 95% CI, 1.02–1.06), sex (males) (OR, 2.27; 95% CI, 1.64-3.13), respiratory disease (OR, 3.74; 95% CI, 2.32–6.04), heart disease (OR, 1.68; 95% CI, 1.14–2.47), cerebrovascular disease (OR, 1.58; 95% CI, 1.11–2.27), liver disease (OR, 2.61; 95% CI, 1.33–5.15), preoperative stay (OR, 1.08; 95% CI, 1.05–1.11) and general anesthesia (OR, 1.61; 95% CI, 1.15-2.27) were identified as independent risk factors for postoperative pneumonia.Conclusions: This study identified several risk factors for pneumonia in geriatric patients after hip fracture operations, providing a viable preventive strategy for optimizing clinical conditions for reductionof postoperative pneumonia.
A framework of safety analysis with temporal feature based on MBSA and case study for ACC system
Authors: Wang Lisong , Zhang Qin , Hu Jun 
Published: December 2021

Abstract
The safety of automotive Adaptive Cruise Control (ACC) system is of great significance to prevent fatigue driving, improve driving comfort, reduce accident rate and promote the development of intelligent transportation and autonomous driving technology. However, the current safety analysis of ACC lacks consideration of the temporal dynamic property, so it is necessary to establish a set of safety analysis methods to consider the temporal characteristics. This paper proposes a new safety analysis method based on MBSA framework and introduces temporal features. Altarica3.0 is a high-level modeling language for safety analysis, and its basic mathematical form is Guardian Transformation System (GTS). In this paper we outline an analysis approach that converts failure behavioral models (GTS) to temporal fault trees (TFTs), which can be analyzed using Pandora a recent technique for introducing temporal logic to fault trees. However, like classical fault tree analysis, TFT analysis requires a lot of manual effort, which makes it time consuming and expensive. In order to improve the safety of the system, the proposal extends Bayesian Networks with Pandora and results to dependability analysis with temporal relationships to provide more reliable basis for safety design. As a typical case study, the safety analysis method proposed in this paper is applied to the safety analysis of adaptive cruise system, and the results show the effectiveness of the proposed method. Furthermore, it also provides new technologies for the automation and intelligence of safety analysis for Smart Internet of Vehicle.
Kinetic, isotherm and thermodynamic aspects of Cu2+ biosorption onto Rosa damascena leaf as a low-cost biosorbent: Optimization of process variables by Response Surface Methodology
Authors: Fawzy Mustafa A. , Al-Yasi Hatim M. , Galal Tarek M. , Hamza Reham Z. , Ali Esmat F. , Abdelkader Tharwat G. 
Published: December 2021

Abstract
In this study, the Rosa damascena leaf powder was evaluated as a biosorbent for copper removal from aqueous solutions. Optimized conditions of 4.0 g/L biosorbent dosage, pH of 5.5 and initial copper concentration of 55 mg/L obtained by Response Surface Methodology were employed for Cu2+ biosorption by R. damascena leaves and up to 88.7 % Cu2+ was removed. The biosorption data were well ﬁtted to the pseudo-second order and Elovich kinetic models. The Langmuir and Dubinin-Radushkevich isotherm models were also best fit the experimental data showing monolayer isotherm with qmax value of 25.13 mg/g obtained at optimum conditions. Thermodynamic parameters showed the spontaneity, feasibility and exothermic nature of adsorption. Scanning electron microscopy, Energy-Dispersive X-Ray, and Fourier transform infrared spectroscopy were used to characterize the biosorbent before and after Cu2+ biosorption, revealing outstanding structural characteristics and high surface functional groups availability. In addition, immobilized R. damascena leaves adsorbed 90.7 % of copper from aqueous solution, which is greater than free biosorbent (85.3 %). It can be concluded that R. damascena might be employed as a low-cost biosorbent for removing heavy metals from aqueous solutions.
The Pyroptosis-Related Signature Predicts Prognosis in Uterine Corpus Endometrial Carcinoma
Authors: Zhang Mengjun , Hou Siyu , Wang Jialin , Yue Haodi 
Published: December 2021

Abstract
Background: Uterine Corpus Endometrial Carcinoma (UCEC) is difficult to evaluate the prognosis. The prognostic evaluation model based on pyroptosis-related genes (PRGs) has shown good predictive power for prognosis in tumors, but there is no relevant research in UCEC. Methods: Based on the gene expression data and clinical prognosis information of UCEC patients from TCGA database, PRGs related to the prognosis were screened out. Based on PRGs, a prognostic evaluation model related was established. Comprehensive analysis of clinical characteristics and prognosis was performed. The potential molecular mechanisms of the prognostic evaluation model was explored by GSEA. The relationship between the prognostic evaluation model and the tumor immune microenvironment (TIME) was delved. Results: 4 key PRGs related to the prognosis (NLRP2, GSDME, NOD2, GPX4) were identified. A prognostic evaluation model based on these 4 key PRGs was established: Riskscore= (0.4323) * GPX4 + (0.2385) * GSDME + (0.0525) * NLRP2 + (-0.3299) * NOD2. A higher risk score was an independent risk factor for the prognosis and closely related to clinical characteristics. The gene expression of the high-risk group was mainly enriched in immune response. The higher risk score was closely related to the degree of immune cell infiltration and the gene expression level of immune checkpoints. Conclusion: The prognostic evaluation model based on 4 key PRGs (NLRP2, GSDME, NOD2 and GPX4) has certain value for the prognosis evaluation and treatment selection of UCEC patients and may affect the prognosis by regulating the TIME.
What stops Korean Immigrants from Accessing Child and Adolescent Mental Health Services?
Authors: Park Chohye , Loy Jik H. , Lillis Steven , Menkes David Benjamin 
Published: December 2021

Abstract
Background: Access to child and adolescent mental health services by ethnic minorities has been poorly studied. Despite rapid growth of the immigrant Korean population, evidence indicates that few Korean families utilise these services in New Zealand. Those that do tend to present late and with significant morbidity. We sought to understand barriers to service access from Korean parents’ perspectives.Method: Seven focus groups were undertaken with 31 Korean parents of children aged 18 and under. The focus groups were semi-structured, held in the Korean language and utilised two case scenarios of common childhood/adolescent mental illnesses around which a set of broad, open ended questions were posed. All conversations were audiorecorded, transcribed and translated into English. Thematic analysis was conducted using NVivo software.Results: Both attitudinal and structural barriers were identified. Attitudinal barriers included attribution of mental illness to external stressors or parenting problems, social stigma, denial or normalization of children’s behaviour, fear of family disempowerment, and mistrust of public mental health services. Structural barriers included parents’ lack of information regarding available services, logistical difficulties in access, communication difficulties, concerns over the quality of translators, and cultural competence of service providersConclusion: Significant barriers prevent Korean immigrant families from accessing child and adolescent mental health services in New Zealand. Measures to improve access, for example by countering stigma, are urgently required.
Children’s Water Intake Lower During In-Person School Compared To Virtual School During COVID-19 Pandemic
Authors: Seal Adam , Hagobian Todd 
Published: December 2021

Abstract
Background: Children’s hydration is often inadequate during school potentially causing detrimental effects on cognitive performance. Previous studies investigating water intake during school lack comparison to a control group. The rise of virtual school during the COVID-19 pandemic created a unique opportunity to assess water intake during school but in a setting outside of school. Objective: Compare water intake of children attending in-person classrooms to water intake of children attending school virtually. We hypothesized water intake would be higher in children attending school virtually.Methods: A validated water intake questionnaire was sent to parents and their children (aged 10-17 years) between September 2020 and March 2021. The questionnaire asked participants how often they consumed a standardized volume of beverage types over one week. Parents indicated if children were attending school in-person or virtually. Results: 54 children indicated they were attending school in-person while 76 indicated attending school virtually (N = 130). Water intake of children attending in-person school (1688 ± 680 mL) was lower as compared to children attending school virtually (1998 ± 831 mL) (F = 5.09, p < 0.05, Figure 1). The multivariate regression examining demographics, parent water intake, and school setting as predictors of child water intake was significant (R2 = 0.33, p < 0.05). Higher child water intake was associated with older age (b = 0.29, p < 0.05), lower family income (b = -0.25, p < 0.05), higher parent water intake (b = 0.39, p < 0.05), and virtual school setting (b = 0.18, p < 0.05).Conclusion: Children’s water intake was higher during virtual school as compared to in-person school. Hydration of parents may influence children, especially when the child is attending school virtually.
Genomic and In Vitro Phenotypic Comparisons of Epidemic and Non-Epidemic Getah Virus Strains
Authors: Mohamed-Romai-Noor Noor-Adila , Sam Sing-Sin , Teoh Boon-Teong , Hamim Zur-Raiha , AbuBakar Sazaly 
Published: December 2021

Abstract

Getah virus is an emerging mosquito-borne animal pathogen. Four phylogenetic groups of GETV, Group I (GI), GII, GIII and GIV, were identified. However, only the GETV GIII was associated with disease epidemics suggesting possible virulence difference in this virus group. Here, we compared the genetic and in vitro phenotypic characteristics between the epidemic and non-epidemic GETV. Our complete coding genome sequence analyses revealed several amino acid substitutions unique to the GETV GIII and GIV groups, which were found mainly in the hypervariable domain of nsP3 and E2 proteins. Replication kinetics of the epidemic (GIII MI-110 and GIII 14-I-605) and non-epidemic GETV strains (prototype GI MM2021 and GIV B254) were compared in mammalian Vero cells and mosquito C6/36 and U4.4 cells. In all cells used, both epidemic GETV GIII MI-110 and GIII 14-I-605 strains showed replication rates and mean maximum titers at least 2.7-fold and 2.3-fold higher than those of GIV B254, respectively (Bonferroni posttest, P<0.01). In Vero cells, the epidemic GETV strains caused more pronounced cytopathic effects in comparison to the GIV B254. Our findings suggest that higher virus replication competency to produce high virus titer during infection may be the main determinant of virulence and epidemic potential of GETV.
Enhanced Resistance To Fungal Pathogens in Transgenic Peanut (Arachis Hypogaea L.) Cultivar L14 by Overexpression of Gene encoding Chitinase 42 kDa from Trichoderma Asperellum SH16
Authors: Hoa Phung Thi Bich , Tue Nguyen Hoang , Trang Huynh Thi Quynh , Thu Hoang Anh , Nhung Le Ngoc Huyen , Luong Nguyen Ngoc , Huy Nguyen Xuan , Tien Nguyen Quang Duc , Loc Nguyen Hoang 
Published: December 2021

Abstract
This study reports the expression of 42 kDa chitinase genes from Trichoderma asperellum SH16 in peanut (Arachis hypogaea) roots under the regulation of tissue-specific Asy promoter through Agrobacterium tumefaciens-mediated transformation. The 42 kDa chitinase genes, including one wild-type sequence (Chi42) and two synthetic sequences (syncodChi42-1 and syncodChi42-2) which were optimized for codon usage for plant expression, were incorporated into the peanut genome and successfully expressed in their roots. The investigation revealed that the enzyme chitinase from two synthetic genes had higher activity than that from the wild-type gene, about 901 U/mg (140 U/mL) and 1124 U/mg (197 U/mL) vs about 508 U/mg (87 U/mL). Transgenic peanut roots also exhibited extracellular chitinase activity which was driven by signal peptide of rice amylase 3D gene against the pathogenic fungus Sclerotium rolfsii under in vitro conditions. The higher chitinase activity of two synthetic genes in peanut roots promises potential applications in the field of transgenic crops against phytopathogenic fungi.
Amplification of Elliptically Polarized Sub-Femtosecond Pulses in Neon-Like X-Ray Laser Modulated By An IR Field
Authors: KHAIRULIN I. R. , АNTONOV V. А. , RYABIKIN М. YU. , BERRILL M. A. , SHLYAPTSEV V. N. , ROCCA J. J. , KOCHAROVSKAYA OLGA 
Published: December 2021

Abstract
Amplification of attosecond pulses produced via high harmonic generation is a formidable problem since none of the amplifiers can support the corresponding PHz bandwidth. Producing the well defined polarization state common for a set of harmonics required for formation of the circularly/elliptically polarized attosecond pulses (which are on demand for dynamical imaging and coherent control of the spin flip processes) is another big challenge. In this work we show how both problems can be tackled simultaneously on the basis of the same platform, namely, the plasma-based X-ray amplifier whose resonant transition frequency is modulated by an infrared field.
Positive Effects of Blue Light on Postural Control and Motor Coordination in Older Adults: A Pilot Study
Authors: Beaven C. Martyn , Uiga Liis , Hébert-Losier Kim 
Published: December 2021

Abstract
Purpose: Falls are a risk factor for mortality in older adults. Light interventions can improve cognitive function and performance in motor tasks, but the potential impact on postural control with relevance to falling is unknown. This study aimed to examine the effect of light on postural control, motor coordination, and cognitive functioning. Methods: Sixteen older adults participated in an intervention study that involved four counter-balanced sessions with blue-enriched light delivered visually and/or transcranially for 12 minutes. Postural control in three conditions (60 s eyes open, dual-task, and eyes closed), lower extremity motor coordination, and cognitive function were assessed. Area of sway (AoS), coordination, and cognitive function were compared between the groups via repeated-measured ANOVA. Results: Relative to placebo, visual blue-enriched light exposure clearly decreased AoS (d = 0.68 ±0.73; p =0.166) and improved reaction time in the motor coordination task (d = 1.44 ±0.75; p =0.004); however, no significant effect was seen on cognitive function. Conclusion Blue-enriched light demonstrates a novel clinical approach to positively impact on postural control and lower-limb motor coordination in older adults. By impacting on metrics associated with fall risk, blue-enriched light may provide a clinically meaningful countermeasure to decrease the human costs of falls.