bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Insights into Interpretation of Aeromagnetic Data for Distribution of Igneous Rocks in Central Iran
Authors: Moghaddam M. Mohammadzadeh , Mirzaei S. , Abedi M. 
Published: December 2021

Abstract
—New insights in the aeromagnetic data over the Central Iranian Microcontinent (CIM) have revealed interesting results for future studies and exploration. This work presents the interpretation of different magnetic analyses and the calculated 3D inversion model to provide important insights into the distribution of igneous rocks in the area that may be traced under significant cover. By analyzing several hundred magnetic susceptibility data points and aeromagnetic anomalies of known igneous rocks over the area, it was determined that mafic–ultramafic intrusive rocks generally have a high magnetic susceptibility and produce a strong magnetic response. Intermediate–felsic intrusive rocks have a low magnetic susceptibility and show a smooth gradient variation and commonly regular shape. Volcanic rocks show a wide range of magnetic susceptibility; therefore, the aeromagnetic anomalies are often random or show strong amplitude with high frequency signals and are rapidly eliminated when an upward continuation is applied. Based on the results of analysis of different magnetic maps and 3D inversion of data, and combining this information with known outcropped of igneous rocks, we revealed 1215 concealed intrusive rocks and 528 volcanic rocks in the area. We also renewed the boundaries of tens outcropped igneous rocks. The known and new mapped igneous rocks can be identified as 12 regions (or zones) for intrusive rocks and 4 regions for volcanic rocks. The results indicate that the mafic–ultramafic rocks are mainly located in the Sistan suture zone of eastern Iran along the Nehbandan fault zone. They also show that the many parts of the Lut block as the main structure of CIM have been under magmatic events, so that most of concealed igneous rocks are distributed in the middle and southern part of the Lut block. Volcanic rocks are widespread in the southeastern and northern parts of the area such as the Urumieh-Dokhtar Magmatic Arc, North Lut, and Bam region.
Paleomagnetism of the Franz Josef Land Archipelago: Application to the Mesozoic Tectonics of the Barents Sea Continental Margin
Authors: Metelkin D.V. , Abashev V.V. , Vernikovsky V.A. , Mikhaltsov N.E. 
Published: December 2021

Abstract
We report new paleomagnetic and geochronological data for rocks of the Franz Josef Land archipelago and generalize available information about the paleomagnetism of the Barents Sea continental margin as applied to the issues of the Mesozoic Arctic tectonics. Specifically, the obtained age estimates are indicative of a brief episode of mantle plume magmatism at the Barremian–Aptian boundary (Early Cretaceous). The paleomagnetic data shows that intraplate magmatism formations in the High Arctic, including the Franz Josef Land traps, are nothing else than a trace of the Iceland plume on the migrating tectonic plates of the region. Thus, the Iceland plume was geographically stationary for at least the last 125 Myr. Our paleotectonic reconstructions suggest a direct connection of the intraplate strike-slip systems of the Eurasian continent with the configuration and subsequent evolution mode of Mesozoic marginal basins and spreading axes during the initial opening stage of the Arctic Ocean.
Increased Fat Mass Leads To Bone Loss, A Prospective Short-Term, 18-Week Study In Young Healthy Men Undergoing Basic Training of The Swiss Army
Authors: Straessle Michael , Grossmann Jonas , Eppenberger Patrick , Faas Alexander , Jerkovic Yvanka , Floris Joël , Öhrström Lena , Akgül Gülfirde , Aldakak Lafi , Rühli Frank J. , Bender Nicole , Staub Kaspar 
Published: December 2021

Abstract
Background: Quantitative ultrasound (QUS) methods have been widely used to assess bone status in osteoporosis. For follow-up examinations, there are no recommendations regarding the use of QUS due to a lack of data. This study aimed to investigate the longitudinal use of QUS in 4 months of military training to assess bone remodelling in association with physical activity and anthropometry.Subjects and methods: We analysed the changes in bone health using calcaneal quantitative ultrasound (Sonost-3000) as well as the impact of anthropometry, body composition, and physical activity in young men at the start (n=104) and 18 weeks later after basic training (n=73).Results: After basic training, the subjects were heavier, slightly taller, and had higher fat mass and grip strength. An overall decrease in physical activity and bone ultrasound attenuation (BUA) was observed. A negative correlation between the development of fat mass and physical activity with BUA was found, with fat mass as the highest impact factor. Development of grip strength correlated positively with SOS, while skeletal muscle mass and waist circumference correlated negatively. Development of skeletal muscle mass and weight had the highest impact on SOS.Conclusion: Overall, subjects were heavier, taller, and fatter and showed increased grip strength, decreased physical activity, and loss of bone health. It is alarming that the increase in fat mass already has a negative effect on the bone structure after 18 weeks. As seen in other studies, the impact of force on bone during walking is insufficient to strengthen it. The results imply that the selected troops of the Swiss army recruits (air defence) have too little high-impact physical activity during their basic training, what should be changed in the future. To verify the worrying results from our study, a prospective randomized study with a survey of low and high impact activities as well as a detailed survey of eating and nutritional habits during basic training should be carried out. QUS seems to be a good tool for assessing bone status, even in the event of short-term changes.
The Effect of Ultrasound-Guided Lung Recruitment Maneuvers On Atelectasis In Lung-Healthy Patients Undergoing Laparoscopic Gynecologic Surgery: a Randomized Controlled Trial
Authors: Liu Yi , Wang Jingyu , Wan Yong , Geng Yuan , Zhang Yiran , Su Hang , Yang Yujiao 
Published: December 2021

Abstract
BackgroundAtelectasis is a major cause of hypoxemia during general anesthesia and postoperative pulmonary complications (PPCs).Some previous reported that the combined use of lung recruitment procedures (LRMs) and positive end-expiratory pressure (PEEP) in mechanical ventilation mode contributes to the avoidance of PPCs in patients after general anesthesia, while others suggest that the use of LRMs makes patients more susceptible to hemodynamic disturbances and lung injury, and is of limited potential to decrease the incidence of PPCs. From this perspective, controversy exists as to whether LRMs should be routinely applied to surgical patients. More importantly, corresponding clinical studies are also lacking. Therefore, this trial was conducted with the aim of solving the above problem.MethodsIn current clinical trial, patients undergoing laparoscopic gynecologic surgery with healthy lungs were randomized to the recruitment maneuvers group (RM group; 6 cm H2O PEEP and RMs) and the control group (C group; 6 cm H2O PEEP and no RMs). Lung ultrasound was performed on patients at five separate time points. During mechanical ventilation, patients in the RM group received ultrasound-guided pulmonary resuscitation when atelectasis was detected, while the C group did not intervene. Lung ultrasound scores were used to evaluate the incidence and severity of atelectasis.ResultsAfter LRMs, the incidence of atelectasis was significantly lower in the RM group (40%) than in the C group (80%) 15 minutes after arrival in the post-anesthesia care unit (PACU), and this difference did not persist for 24 hours after surgery. Meanwhile, postoperative pulmonary complications showed no difference between the two groups.ConclusionsThe combination of LRMs and PEEP decreased the incidence of atelectasis 15 minutes after admission to the PACU, but did not improve PPCs in adults with healthy lungs. Hence, for lung-healthy patients undergoing gynecological laparoscopic surgery, we do not recommend routine recruitment maneuvers. Trial registration: (prospectively registered): ChiCTR2000033529. Registered on 6/4/2020.
High CENPM Gene Expression Predict Poor Survival Outcome in Lung Adenocarcinoma
Authors: Huang Zhe , Yang Nong , Zhang Yongchang 
Published: December 2021

Abstract
Introduction: Lung adenocarcinoma is a disease with high morbidity and mortality. The aim of our study was to investigate the relationship between the gene expression of centromere protein M (CENPM) and its prognostic impact in lung adenocarcinoma.Method: By analyzing the data of lung adenocarcinoma in database, the CENPM gene expression in lung adenocarcinoma and its relationship with clinical stage and survival time were analyzed using datasets from The Cancer Genome Atlas (TCGA)and Gene Expression Omnibus (GEO) datasets. Genes associated with CENPM expression were analyzed and subjected to functional and pathway enrichment analysis. Finally, the genetic results and treatment and survival outcomes of 20 patients with lung adenocarcinoma from our hospital were analyzed.Result: CENPM transcripts were found to be highly expressed in lung adenocarcinoma as compared with normal tissues (3.628 VS. 2.227, P < 0.001). CENPM expression was positively associated with tumor stage (3.803 vs. 3.444, p < 0.001) and nodal stage (3.992 vs. 3.573, p < 0.001). Patients with low CENPM expression achieved better progression-free survival (45.9 months vs. 25.7months, p < 0.001) and overall survival (57.5 months vs. 47.5 months, p=0.001). The CENPM expression was negatively correlated with the infiltration of most immune cells in lung adenocarcinoma tissues and positively correlated with PD1 (r = 0.231, p < 0.001) and PD-L1 (r = 0.116, p < 0.007). CENPM-related genes were enriched in the set of genes with poor prognosis as well as the set of cell cycle-related genes in lung adenocarcinoma. CENPM expression was also negatively correlated with T lymphocyte and B lymphocyte signaling pathways. Finally, CENPM-related genes were related in Rho GTPases and ATR signaling pathways.Conclusion: Our findings demonstrate that CENPM gene is highly expressed and is associated with poor prognosis in lung adenocarcinoma.
ASPSCR1-TFE3 orchestrates the angiogenic program of alveolar soft part sarcoma
Authors: Tanaka Miwa , Chuaychob Surachada , Homme Mizuki , Yamazaki Yukari , Lyu Ruyin , Yamashita Kyoko , Ae Keisuke , Matsumoto Seiichi , Maruyama Reo , Qu Wei , Miyagi Yohei , Yokokawa Ryuji , Nakamura Takuro 
Published: December 2021

Abstract
Alveolar soft part sarcoma (ASPS) is a soft part malignancy affecting adolescents and young adults. ASPS is characterized by a highly integrated vascular network, and its high metastatic potential indicates the importance of ASPS’s prominent angiogenic activity. Here, we found that the expression of ASPSCR1-TFE3, the fusion transcription factor causatively associated with ASPS, is dispensable for in vitro tumor maintenance; however, it is required for in vivo tumor development via angiogenesis. ASPSCR1-TFE3 is frequently associated with super-enhancers (SEs) upon its DNA binding, and the loss of its expression induces SE-distribution dynamic modification related to genes belonging to the angiogenesis pathway. Using epigenomic CRISPR/dCas9 screening, we identified Pdgfb, Rab27a, Sytl2, and Vwf as critical targets associated with reduced enhancer activities due to the ASPSCR1-TFE3 loss. Upregulation of Rab27a and Sytl2 promotes angiogenic factor-trafficking to facilitate ASPS vascular network construction. ASPSCR1-TFE3 thus orchestrates higher ordered angiogenesis via modulating the SE activity.
Reconstructed Brain Like Neural Network R-KFDNN
Authors: rongrong zhu 
Published: December 2021

Abstract
Through the neural system damage and repair process of human brain, we can construct the complex deep learning and training of the repair process such as the damage of brain like high-dimensional flexible neural network system or the local loss of data, so as to prevent the dimensional disaster caused by the local loss of high-dimensional data. How to recover and extract feature information when the damaged neural system (flexible neural network) has amnesia or local loss of stored information. Information extraction generally exists in the distribution table of the generation sequence of the key group of the higher dimension or the lower dimension to find the core data stored in the brain. The generation sequence of key group exists in a hidden time tangent cluster. Brain like slice data processing runs on different levels, different dimensions, different tangent clusters and cotangent clusters. The key group in the brain can be regarded as the distribution table of memory fragments. Memory parsing has mirror reflection and is accompanied by the loss of local random data. In the compact compressed time tangent cluster, it freely switches to the high-dimensional information field, and the parsed key is buried in the information.
On Injectivity of an Integral Operator Connected to Riemann Hypothesis
Authors: Adam Dumitru 
Published: December 2021

Abstract
Using the equivalent formulation of RH given by Beurling ([4],1955), Alcantara-Bode showed ([2], 1993) that Riemann Hypothesisholds if and only if the integral operator on the Hilbert space L2(0; 1)having the kernel defined by fractional part function of the expressionbetween brackets {y/x}, is injective.Since then, the injectivity of the integral operator used in equivalentformulation of RH has not been addressed nor has been dissociatedfrom RH and, a pure mathematics solution for RH is not ready yet.Here is a numerical analysis approach of the injectivity of the linearbounded operators on separable Hilbert spaces addressing the problemslike the one presented in [2]. Apart of proving the injectivity of theBeurling - Alcantara-Bode integral operator, we obtained the followingresult: every linear bounded operator (or its associated Hermitian),strict positive definite on a dense family of including approximationsubspaces in L2(0,1) built on simple functions, is injective if the rateof convergence to zero of its unbounded sequence of inverse conditionnumbers on approximation subspaces is o(n-s) for some s ≥ 0. Whens = 0, the sequence is inferior bounded by a not null constant, that isthe case in the Beurling - Alcantara-Bode integral operator.In the Theorem 4.1 we addressed with numerical analysis toolsthe injectivity of the integral operator in [2] claiming that - even if asolution in pure mathematics is desired, together with the Theorem 1,pg. 153 in [2], the RH holds.
A new global optimum solution model based on multi-value dynamic programming for the cut-off grade optimization in a surface mining complex
Authors: Biswas Pritam , Sinha Rabindra Kumar , Sen Phalguni 
Published: December 2021

Abstract
In techno-economic concern, cut-off grade (COG) optimization is the key for efficient mineral liquidation from thehuge metalliferous surface mining sector. In this paper, a sequentially advancing algorithm based on discretemulti-value dynamic programming (MDP) has been developed to calculate the global optimum COG of alarge-scale open-pit metalliferous deposit. The proposed COG optimization algorithm aims to overcome thelimitations of straightforward classical techniques in determining the optimum COG. This discrete COG-MDPmodel is the first of its kind and has the novelty of dealing with the simulation of eight dynamic possibilities toachieve the maximal global Net Present Value (NPV). A high-level programming language (Python) has been usedto develop the computer model to deal with the complexity of handling a minimum of 500 series of dynamicvariables. This model can generate results in polynomial-time from the complex of mining, milling, and smeltingand refining system corresponding to various limiting conditions. The prime objective considered in the model isto optimize the COG of a metalliferous deposit. A working open-pit copper mining complex from India has beenused to validate the model. In this study, the optimum COG for the Malanjkhand copper deposit has been found tobe (0.33%, 0.23%, 0.52%, 0.26%, 0.27%, 0.22%, 0.24%) with a maximum NPV of ₹ (12204, 14653, 16948, 14609,21454, 26717, 38821) million corresponding to various scenarios. The findings also show that the present valuegradually hits zero after the project’s life cycle, confirming the typical pattern of other mining firms.
Clinical application of concentrate growth factors combined with bone substitute in Alveolar ridge preservation of anterior teeth
Authors: Keranmu Dilinuer , Nuermuhanmode Nijiati , Ainiwaer Ailimaierdan , Moming Adili , Li Gu , Taxifulati Dilidaer , Shan Wang , Ling Wang 
Published: December 2021

Abstract
Objective: To investigate the clinical effect of concentrated growth factors (CGF) combined with Bio-oss bone powder on Alveolar ridge preservation (ARP) during implantology.
Methods: A total of 38 patients were selected and randomly divided into 2 groups, with 19 cases in each group. The extraction sockets were filled with Bio-oss bone powder with or without CGF. VAS pain score was recorded within1 week and Landry wound healing index (LWHI) was recorded at 1, 2 and 3 weeks after operation. CBCT was taken 3 and 6 months after operation to measure and compare the changes of vertical height, width and gray value of alveolar bone at extraction site. The changes of alveolar bone contour were observed clinically and compared between the two groups.
Results: The VAS score of CGF group was lower than control group on the 1st and 3rd day after operation (P < 0.05). The LWHI of CGF group was higher than control group 1 week after operation (P < 0.05). The absorption of the labial and palatal plates height and the width in the CGF group was significantly less than the control group at 3 months (P<0.05). The gray value of alveolar bone in CGF group was significantly higher than control group at 3 months (P < 0.05). There was no significant difference in new bone contour between the two groups (P > 0.05). 94.7% cases in CGF group did not undergo bone grafting, which was significantly higher than control group (78.9%).
Conclusions: The use of CGF combined with Bio-oss bone powder can help to reduce postoperative pain at the early stage of healing, form sufficient keratinized gingival tissue, effectively maintain the height and width of alveolar bone in the three-dimensional direction and provide good conditions for implant repair in the future.
Human Umbilical Cord-Derived Mesenchymal Stem Cells Alleviate Acute Lung Injury Caused by Severe Burn via Secreting TSG-6 and Inhibiting Inflammatory Response
Authors: Hu Xiaohong , Liu Lingying , Wang Yu , Li Zhongyuan , Yu Yonghui , Chai Jiake , Liu Yanan 
Published: December 2021

Abstract
Objectives To investigate whether hUC-MSCs attenuated severe burn-induced ALI and the effects were based on TSG-6 secreted from hUC-MSCs. Method Rat model was established and evaluated as follows：Anires2005 animal pulmonary function tester for pulmonary function; micro-CT scanner for lung imaging manifestations; cytokine expression was measured by ELISA assay, and both inflammatory cell infiltration and lung injury were assessed by immunohistochemistry assay. Results In vitro, TSG-6 levels in serum from the burn group were significantly increased than that of the sham group. In vivo, TSG-6 levels of lung tissues and serum in the burn+ hUC-MSCs group were significantly increased than those of that in the burn group. Higher parameters of airway resistance（Ri, Re, etc）were markedly decreased, and the disordered lung texture and funicular density shadows were significantly improved after hUC-MSCs administration. Both in lung tissues and serum, increased levels of proinflammatory cytokines（TNF-α, IL-1β, IL-6）were remarkably decreased, but anti-inflammatory cytokine IL-10 increased after hUC-MSCs administration (p<0.05). These significant positive effects after hUC-MSCs transplantation did not occur in the Burn+siTSG-6 group. Conclusion Intra-tracheal implantation of hUC-MSCs has been an effective treatment for severe burn-induced ALI via promoting TSG-6 secretion and inhibiting inflammatory reaction in lung tissue.
L'hétéroglossie littéraire dans Illusions perdues de Balzac: Enjeux, fonctions et limites
Authors: Bourasse Mohamed 
Published: December 2021

A lire Illusions perdues, le premier constat qui frappe le lecteur, est l’extrême diversité du langage de ses personnages. Balzac ouvre sa langue littéraire sur une infinité de discours oraux et écrits, de nature familière, régionale, diachronique.... Et ce, par l’usage d’une palette diverse de variantes linguistiques, se répartissant en sociolectes, idiolectes, régiolectes…, phénomène que certains chercheurs appellent ‘’l’hétéroglossie[1] littéraire’’. Tous les types de variation parsèment le roman et la langue balzacienne n’est pas homogène et monolithique, mais hétérologique et hétéroglossique. Notre objectif dans cette réflexion est de problématiser cette notion d’hétéroglossie littéraire dans une perspective littéraire et sociolinguistique (variationniste). Pour ce faire, nous étudierons les raisons et les motivations de cette pratique, ainsi que ses effets et ses fonctions. Aussi, nous examinerons les écueils que ce phénomène peut produire dans l’œuvre.

[1] Terme de Rainier Grutman. In : Grutman, R. Des langues qui résonnent. L’hétérolinguisme au XIXe siècle québécois. Montréal : Fides/Cétuq, 1997.
ALIMENTAÇÃO: ENTRE A MEMÓRIA, O PATRIMÔNIO E A IDENTIDADE
Authors: Piedade Ana 
Published: December 2021

A alimentação é uma questão importante do Património Cultural Imaterial. A sua dimensão de saber e saber-fazer, transmitidos de geração em geração, alicerçados principalmente nas tradições orais e centrados nas práticas culturais e sociais, conferem poder, identidade e continuidade temporal às comunidades. Em 2000, o Conselho de Ministros de Portugal emanou uma resolução que visa estudar e preservar “o receituário tradicional português, assente, designadamente, em matérias-primas de fauna e flora utilizadas ao nível nacional, regional ou local, bem como em produtos agroalimentares produzidos em Portugal, e que, pelas suas características próprias, revele interesse do ponto de vista, histórico, etnográfico, social ou técnico, evidenciando valores de memória, antiguidade, autenticidade, singularidade ou exemplaridade” (RCM Nº 96/2000). Assim, a lei estabelece diversas regras com o objetivo de preservar e desenvolver a promoção de uma gastronomia nacional como elemento representativo do património cultural português. O processo de definição das bases do patrimônio é uma construção das elites e possui uma dimensão política e ideológica que não pode ser escamoteada e que determina o que deve ser valorizado, num determinado momento temporal e contexto político. Neste sentido, os territórios são quebra-cabeças políticos que refletem identidades desejadas e transitórias, ao mesmo tempo cristalizadas e transformadas no tempo. O património é dotado de uma dimensão política determinante na identidade gastronómica e alimentar, no que se refere ao local, regional e global. Já as instituições de governança local buscam estimular os territórios sob a sua influência, por meio da aceitação e / ou promoção de ações de marketing e “rótulos” geradores de marcas locais que, muitas vezes, reforçam símbolos de identidade ou os (re) inventam. Os processos de turistificação dos lugares históricos e centros das cidades estão pouco distantes dessas atitudes e, tal como nestes casos, a intenção inicial de preservação dos sistemas alimentares, pode resultar na adulteração dos pratos servidos