bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-made university rankings: Categorization tactics and communication activism in Italian universities
Authors: Bonaccorsi Andrea , Belingheri Paola , Blasi Brigida , Romagnosi Sandra 
Published: February 2021

AbstractHigher education institutions increasingly live in environments in which they are subject to evaluation and rankings. We examine the way in which Italian (mostly public) universities adapted to the new landscape created by the official research assessments, which have produced rankings at national level, published in 2013 and 2016. We compare the media coverage of rankings after the first research assessment (covering 2004–10) and the second one (2011–4). By examining the same type of media data longitudinally, replicating regression analysis, and using robustness checks, we discover a remarkable degree of organizational adaptation. After the initial shock following the first research assessment (2004–10), in which universities were mostly passive, universities rapidly learnt how to deal with rankings. After the second exercise, they actively and professionally communicated with the media, building up self-made rankings data aimed at protecting and enhancing their image, using a range of categorization tactics.
Optimal Taxation with Private Insurance
Authors: Chang Yongsung , Park Yena 
Published: February 2021

Abstract
We derive a fully non-linear optimal income tax schedule in the presence of private insurance. We fill the gap in the literature by studying the optimal tax formula with a comprehensive structure of the private markets—including incomplete markets models—both theoretically and quantitatively. As in the standard taxation literature without private insurance, the optimal tax formula can still be expressed in terms of standard sufficient statistics. With private insurance, however, the formula involves additional terms that reflect how the private market interacts with public insurance. For example, the optimal tax formula should also consider asset distribution and pecuniary externalities as well as the welfare effects of borrowing constraints.
Psychosis in systemic lupus erythematosus (SLE): 40-year experience of a specialist centre
Authors: Abrol Esha , Coutinho Ester , Chou Michael , Hart Melanie , Vincent Angela , Howard Robert , Zandi Michael S , Isenberg David 
Published: February 2021

Abstract

Objectives
The long-term outcome of psychosis in association with systemic lupus erythematosus (SLE) has been insufficiently characterised. We used a specialist centre cohort of patients with SLE and psychosis to investigate their clinical outcome and phenotypic and laboratory characteristics.

Methods
Retrospective cohort study of 709 SLE patients seen at a specialist centre between January 1978 and November 2018. Clinical, biochemical and immunological characteristics (Bonferroni corrected), and serum neuronal surface antibody profile using novel cell-based assays, were compared between patients with and without psychosis.

Results
Eighteen (18/709, 2.5%) patients developed lupus psychosis over a mean ± SD of 17.5 ± 11.0 years follow-up. Psychosis fully remitted in 66.7% (12/18) with a combination of antipsychotic (in 38.9%) and immunosuppressive therapy (methylprednisolone 72.2%, cyclophosphamide 55.6%, rituximab 16.7%, plasma exchange 27.8%, prednisolone 50%). Patients who developed lupus psychosis may be more likely to have anti-RNP antibodies (50.0% vs 26.5%) and less likely to have anti-cardiolipin antibodies (5.6% vs 30.0%), but this was not significant in our small sample. Neuronal surface autoantibody tests found GABABR autoantibodies in 3/10 (30.0%) lupus psychosis patients compared with only 3/27 (11.1%) in age- and sex-matched SLE controls using fixed cell-based assays (P =0.114). However, GABABR antibodies were not replicated using a live cell-based assay. NMDAR-antibodies were not detected with fixed or live cell assays in any samples.

Conclusion
Lupus psychosis is rare but treatable. In this rare sample of eighteen patients from a 40-year cohort, no significant biomarker was found, but some preliminary associations warrant further exploration in a larger multicentre analysis.
Discourses of Gender and Political Violence in South Africa
Authors: Cornell Josephine , Malherbe Nick , Seedat Mohamed , Suffla Shahnaaz 
Published: February 2021

Abstract
Politically violent women are regularly muted or made exceptional. Yet, underplaying women’s involvement in political violence obscures the systemic nature of such violence. We employ a discursive psychology analysis of an in-depth interview with a South African woman who has been involved in decades of political activism, and identified two discourses: Gendering Politically Violent Symbols and Enactments, where political violence was wielded as a symbol, and Gendering Political Organizing, wherein feminist agencies were directed against political structures. Together, these discourses indicate how gender identity is simultaneously consistent and at odds with political identity and how gender intersects with political violence.
Meta-analysis of the operative treatment of lumbar disc herniation via transforaminal percutaneous endoscopic discectomy versus interlaminar percutaneous endoscopic discectomy in randomized trials
Authors: He Ding-Wen , Xu Yan-Jie , Chen Wei-Cai , Miao Xin-Xin , Wu Hui , Wu Tian-Long , Jia Jing-Yu , Cheng Xi-Gao 
Published: February 2021

Abstract

Backgrounds:
Transforaminal percutaneous endoscopic discectomy (TF-PELD) and interlaminar percutaneous endoscopic discectomy (IL-PELD) are the most common alternative treatments of lumbar disc herniation. The aim of this study was to compare the operation time duration and X-ray exposure as well as outcomes of TF-PELD and IL-PELD as indicated by the published clinical evidences within randomized trials.

Methods:
We included randomized, controlled studies reporting operation duration and X-ray exposure as well as clinical outcome evaluations, comparing TF-PELD to IL-PELD with a minimum of 10 patients per group. The included data measures were operation duration, X-ray exposure and postoperation evaluations. Data were synthesized and analyzed using ReviewManager version 5.3. Publication bias was evaluated via funnel plot. The Cochran Q test and the degree of inconsistency (I
2) were used to assess heterogeneity. Lowly biased and heterogenous dichotomous data were calculated by odds ratio and continuous data were calculated by mean difference (MD) with 95% confidence intervals (CI).

Results:
Thirteen studies published from January 1970 to March 2018, with a total of 770 lumbar disc herniation patients, including 361 cases of TF-PELD and 409 cases of IL-PELD, were finally included. Meta-analysis of data extracted from these studies revealed that the postoperation outcomes of both surgery methods did not differ significantly, but the surgery duration was significantly shorter in the IL-PELD group than in the TF-PELD group (MD 21.69; 95% CI 12.94–30.27; P = .00001), and the fluoroscopy times demanded in the IL-PELD group was significantly fewer than those in the TF-PELD group (MD 7.57; 95% CI 6.22–8.93; P = .00001).

Conclusion:
The main finding of the study is that IL-PELD approach can decrease radiation exposure as their demanded duration of operation and fluoroscopy times were significantly shorter and fewer in the IL-PELD group, which they achieve similar outcomes comparing to TF-PELD. The study is limited at a lack of samples with lumbar disc herniation levels out of L5/S1. The findings implicate selection of IL-PELD approach over TF-PELD at applicable circumstances for lower lumbar disc herniation. Physicians should consider this data when choosing between TF-PELD and IL-PELD.
Screening of potential biomarkers for distinguishing between latent and active tuberculosis in children using bioinformatics analysis
Authors: Shao Meng , Wu Fang , Zhang Jie , Dong Jiangtao , Zhang Hui , Liu Xiaoling , Liang Su , Wu Jiangdong , Zhang Le , Zhang Chunjun , Zhang Wanjiang 
Published: February 2021

Abstract
Tuberculosis (TB) is one of the leading causes of childhood morbidity and death globally. Lack of rapid, effective non-sputum diagnosis and prediction methods for TB in children are some of the challenges currently faced. In recent years, blood transcriptional profiling has provided a fresh perspective on the diagnosis and predicting the progression of tuberculosis. Meanwhile, combined with bioinformatics analysis can help to identify the differentially expressed genes (DEGs) and functional pathways involved in the different clinical stages of TB. Therefore, this study investigated potential diagnostic markers for use in distinguishing between latent tuberculosis infection (LTBI) and active TB using children's blood transcriptome data.
From the Gene Expression Omnibus database, we downloaded two gene expression profile datasets (GSE39939 and GSE39940) of whole blood-derived RNA sequencing samples, reflecting transcriptional signatures between latent and active tuberculosis in children. GEO2R tool was used to screen for DEGs in LTBI and active TB in children. Database for Annotation, Visualization and Integrated Discovery tools were used to perform Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analysis. STRING and Cytoscape analyzed the protein-protein interaction network and the top 15 hub genes respectively. Receiver operating characteristics curve was used to estimate the diagnostic value of the hub genes.
A total of 265 DEGs were identified, including 79 upregulated and 186 downregulated DEGs. Further, 15 core genes were picked and enrichment analysis revealed that they were highly correlated with neutrophil activation and degranulation, neutrophil-mediated immunity and in defense response. Among them TLR2, FPR2, MMP9, MPO, CEACAM8, ELANE, FCGR1A, SELP, ARG1, GNG10, HP, LCN2, LTF, ADCY3 had significant discriminatory power between LTBI and active TB, with area under the curves of 0.84, 0.84, 0.84, 0.80, 0.87, 0.78, 0.88, 0.84, 0.86, 0.82, 0.85, 0.85, 0.79, and 0.88 respectively.
Our research provided several genes with high potential to be candidate gene markers for developing non-sputum diagnostic tools for childhood Tuberculosis.
Effect of acupoint catgut embedding in chronic fatigue syndrome patients
Authors: Zhang Mei-Lin , Fu Hong-Juan , Tang Yong , Luo Zhen-Guo , Li Jian-Yong , Li Rui 
Published: February 2021

Abstract

Background:
Chronic fatigue syndrome (CFS) is a relatively complex and disabling illness with a substantial economic burden and functional impairment. Until now, many CFS patients lack appropriate healthcare. Acupoint catgut embedding is an effective and emerging alternative therapy for CFE. With this research, we endeavor to investigate the effect and safety of ACE for CFS.

Methods:
Eight databases will be searched from inception to December 2020: PubMed, EMBASE, The Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Chong-Qing VIP database, and Wan-fang database. We regard studies as eligible for inclusion if they were RCTs done in CFS patients, compare acupoint catgut embedding to another treatment strategy, and report fatigue changes at the end of the intervention period. Two independent reviewers complete the study selection, data extraction, and the risk of bias assessment. We assess pooled data using a random-effects model through Revman software (v.5.3) and Stata (version 15.0).

Ethics and dissemination:
Ethics approval is not required because the individual patient data will not be involved, with no privacy concerns. This systematic review and meta-analysis will provide a reference for CFS patients and clinicians on the non-drug interventions. We will publish and disseminate the results of this review in a peer-reviewed journal or relevant conference.

OSF Registration number:
10.17605/OSF.IO/7SHD9 (https://osf.io/7shd9).
Long-term effects of regular exercise during pregnancy on overweight and obese gravidas
Authors: Zhang Ying , Yang Yi , Xiong Guoping , Yu Fen 
Published: February 2021

Abstract

Background:
Overweight before pregnancy is independent risk factor for diabetes mellitus. This randomized controlled trial was to investigate the long-term effects of regular exercise during pregnancy on overweight and obese gravidas.

Methods and analysis:
This single-center, prospective, randomized controlled test will be conducted in Wuhan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology. Overweight and obese pregnant women will be included in our study and randomized into 2 groups: regular exercise and control groups. The informed consent will be acquired in each patient. Body weight, body fat, fasting and 2 h glucose level in 75 g oral glucose tolerance test (OGTT), insulin resistance index, and lipid profiles were compared. We also evaluated their physical activities with International Physical Activity Questionnaire (IPAQ), their dietary habits with modified Adult Dietary Behavior Assessment Scale, and depression condition with Postpartum Depression Screen Scale (PDSS). The significance level was defaulted as P < .05.

Results:
Results will be published in relevant peer-reviewed journals.

Conclusion:
Our study aims to systematically assess the effects of regular exercise for overweight and obese gravidas, which will be provided clinical guidance for overweight and obese gravidas.
Peripheral T lymphocytes predict the severity and prognosis in patients with HBV-related acute-on-chronic liver failure
Authors: Wang Feixia , Sun Weiwei , Xiao Qian , Liang Chongfeng , Jiang Shulian , Lian Yanan , Shao Jiangjuan , Tan Shanzhong , Zheng Shizhong 
Published: February 2021

Abstract

Background:
Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a life-threatening syndrome with high mortality. Biomarkers are urgently needed to predict the prognosis of HBV-ACLF. Recent evidence suggests a key role for immune system in the pathology of HBV-ACLF. Here, we analyzed the correlation between peripheral blood T lymphocytes and the severity and prognosis in HBV-ACLF patients.

Method:
Sixty-six patients with HBV-ACLF received conventional medical treatments for 4 weeks. Twenty-five healthy subjects and 20 HBV patients were enrolled for comparison. We determined white blood cell count, lymphocytes, CD3+, CD4+ and CD8+ T cells, and CD4+CD25+ Treg cells in the blood of all subjects. Their associations with laboratory parameters before or after treatments were statistically analyzed.

Result:
The results showed that compare normal subjects and chronic hepatitis B patients, HBV-ACLF patients had significantly increased white blood count, CD4+ T cells and decreased lymphocytes, CD3+ T cells, and Treg cells. Correlation analysis showed that white blood cell, lymphocytes, and peripheral T lymphocytes were correlated with prothrombin activity (PTA) and model for end-stage liver disease (MELD) scores. After treatment, white blood cell, lymphocytes, and peripheral T lymphocytes were also correlated with PTA and MELD scores. Additionally, total bilirubin (TBIL), alanine aminotransferase (ALT), international standard ratio (INR), MELD, and white blood cell count were potential prognostic criteria for HBV-ACLF patients.

Conclusion:
HBV-ACLF patients had depletion and dysfunction of immune system. Changes of peripheral T lymphocytes were closely related to the pathogenesis and prognosis of disease. Our results may contribute to predict the severity of HBV-ACLF, and provide a prognosis response to improve the treatment of HBV-ACLF.
The efficacy and safety of Xuebijing injection in the treatment of radiation pneumonitis
Authors: Li Zheng , Wang Dandan , Zhang Ying , Wang Shuo , Wang Xueqian , Li Yuxiao , Gui Yuerong , Dong Jun , Hou Wei 
Published: February 2021

Abstract

Background:
At present, the treatment of radiation pneumonitis (RP) is still a clinical problem. Although a variety of drugs such as glucocorticoids and antibiotics are used for RP treatment, side effects remain to be inevitable. Xuebijing injection (XBJ), a Chinese herbal injection, has been widely used in RP treatment, but there is no published systematic review to evaluate its efficacy and safety.

Methods:
Based on Preferred Reported Items for Systematic Review and Meta-analysis guidelines, we will conduct this systematic review and meta-analysis. Related randomized controlled trials will be searched in 7 databases: PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure, WANFANG database, SinoMED, and China Science and Technology Journal Database from inception of the library to October 1, 2020. Two researchers will independently carry out literature screening, data extraction, and bias risk assessment. The primary outcome is total effective rate and the secondary outcome is inflammation-related indicators such as C-reactive protein, tumor necrosis factor alpha, interleukin-6, interleukin-10, etc and adverse events. Cochrane Review Manager (RevMan 5.3) software will be applied to analyze the data and generate forest plot and funnel plot.

Results:
This study will provide a synthesis of current evidence of XBJ in RP treatment including total effective rate and inflammation-related indicators such as CRP, TNF-α, IL-6, IL-10, etc. and adverse events (AEs).

Conclusion:
This systematic review and meta-analysis will objectively evaluate the efficacy and safety of XBJ in the treatment of RP, and provide evidence for the application of XBJ in RP treatment.

Systematic review registration number:
INPLASY2020120037
Malignant adenomyoepithelioma of the breast
Authors: Zhang Zhihao , Wang Yueyuan , Xie Xiao , Peng Jingyu , Hong Jinghui , Bi Lirong , Yang Ming 
Published: February 2021

Abstract

Rationale:
Adenomyoepithelioma (AME) is a rare biphasic tumor consisting of epithelial and Myoepithelial cell. Most of the AME is benign, and only a few will progress to malignancy, Here, we report a case of low-grade malignant adenomyoepithelioma, and review the related literature, in a bid to investigate its clinical and pathological features and thus, enhance our understanding of this tumor.

Patient concerns:
A 64-year-old woman visited our hospital with a 1-year history of a painless mass in her left breast. Physical examination revealed a palpable painless mass, measuring approximately 4.5 cm, in the left breast.

Diagnosis:
Histological examination confirmed the diagnosis of malignant adenomyoepithelioma

Interventions:
The patient underwent local excision of the mass, with frozen section analysis revealing ductal carcinoma in situ. Mastectomy and sentinel lymph node biopsy were then performed.

Outcomes:
We conducted a one-year follow-up, and relapse was not observed.

Lessons:
Treatment of AME remains controversial owing to the lack of high volume data and absence of prospective studies. Simple mastectomy is an acceptable treatment of this tumor.
Nurse Leaders Employ Contemplative Practices to Promote Healthcare Professional Well-being and Decrease Anxiety
Authors: Cunningham Tim , Çayir Ebru 
Published: February 2021

OBJECTIVE
The purpose of this study was to test the effectiveness of a daylong resilience retreat on healthcare professionals' anxiety levels, intention to engage in mindfulness practices, and self-efficacy around mindfulness.

BACKGROUND
Caregiver burnout is a concern that needs to be addressed at the organizational level so that professionals can reduce their risk of psychological injury while providing high-quality care. The COVID-19 (novel coronavirus) pandemic has exacerbated symptoms of burnout among nurses nationally.

METHODS
Ten sessions of daylong resilience retreats were delivered to independent groups of nurses, nurse practitioners, and other healthcare professionals. Preretreat and postretreat assessments were completed using a 19-item survey developed by the research team to assess state anxiety, intention to engage in mindfulness practices, and self-efficacy around mindfulness.

RESULTS
One hundred six healthcare professionals completed the resilience retreats. There was a statistically significant decrease in state anxiety scores following the retreat. The majority of the participants reported high intentions to engage in mindfulness practices and felt confident about incorporating mindfulness in their lives.

CONCLUSIONS
Brief resilience retreats endorsed by nurse leadership can reduce perceived anxiety and facilitate engagement in contemplative practices, which are associated with a decrease in the risk of burnout.
Lockdown benefit varies among countries and sub-national units: a reanalysis of the data by Bendavid et al. (2021)
Authors: Boesch Lukas 
Published: February 2021

AbstractAre the lockdown measures limiting the propagation of COVID-19? Recent analyses on the effectiveness of non-pharmaceutical interventions in reducing COVID-19 growth rates delivered conflicting conclusions. While Haug et al. (2020) did find strong empirical support for reductions in COVID-19 growth rates, Bendavid et al. (2021) did not. Here, I present the results of a reanalysis of the data by Bendavid et al. (2021). Instead of relying on pairwise comparisons between 10 countries with fixed-effects regression models to isolate the effect of lockdown measures, I modelled the development of the pandemic with and without lockdown measures for the entire period and all countries included in the data with one mixed-effects regression model. My results reconciled the conflicting conclusions of Haug et al. (2020) and Bendavid et al. (2021): while mandatory business closure orders did not affect COVID-19 growth rates, a general decrease in COVID-19 growth rates was attributable to the implementation of mandatory stay-at-home orders. However, the effect of mandatory stay-at-home orders varied, being weaker, even zero, in some countries and sub-national units and stronger in others, where COVID-19 growth rates only decreased due to the implementation of mandatory stay-at-home orders. The heterogeneity in the effect of mandatory stay-at-home orders on the spread of COVID-19 is challenging from a scientific and political point of view.