bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Design of Replication Studies
Authors: Hedges Larry V. , Schauer Jacob M. 
Published: March 2021

Abstract
Empirical evaluations of replication have become increasingly common, but there has been no unified approach to doing so. Some evaluations conduct only a single replication study while others run several, usually across multiple laboratories. Designing such programs has largely contended with difficult issues about which experimental components are necessary for a set of studies to be considered replications. However, another important consideration is that replication studies be designed to support sufficiently sensitive analyses. For instance, if hypothesis tests are to be conducted about replication, studies should be designed to ensure these tests are well-powered; if not, it can be difficult to determine conclusively if replication attempts succeeded or failed. This paper describes methods for designing ensembles of replication studies to ensure that they are both adequately sensitive and cost-efficient. It describes two potential analyses of replication studies—hypothesis tests and variance component estimation—and approaches to obtaining optimal designs for them. Using these results, it assesses the statistical power, precision of point estimators and optimality of the design used by the Many Labs Project and finds that while it may have been sufficiently powered to detect some larger differences between studies, other designs would have been less costly and/or produced more precise estimates or higher-powered hypothesis tests.
Bias in assessment: name, reframe, and check in
Authors: Fainstad Tyra L. , McClintock Adelaide H. , Yarris Lalena M. 
Published: March 2021

AbstractCognitive bias permeates almost every learner assessment in medical education. Assessment bias has the potential to affect a learner's education, future career and sense of self‐worth. Decades of data show that there is little educators can do to overcome bias in learner assessments. Using in‐group favouritism as an example, we offer an evidence‐based, three‐step solution to understand and move forward with cognitive bias in assessment: (1) Name: a simple admission about the presence of inherent bias in assessment, (2) Reframe: a rephrasing of assessment language to shed light on the assessor's subjectivity and (3) Check‐in: a chance to ensure learner understanding and open lines of bidirectional communication. This process is theory‐informed and based on decades of educational, sociological and psychological literature; we offer it as a logical first step towards a much‐needed paradigm shift towards addressing bias in learner assessment.
Benefits of lower neonatal platelet transfusion thresholds
Authors: Hasan Rida , Saifee Nabiha H. 
Published: March 2021

Key Ideas
Degree of thrombocytopenia is not a predictor of bleeding risk in neonates, yet most platelet transfusions are given prophylactically in non‐bleeding premature infants.
Recent data support a lower platelet transfusion threshold of 25 × 109/L in non‐bleeding premature neonates and indicate that higher transfusion thresholds may be associated with harm including increased risk of death and bleeding.
The mechanism of increased adverse events with higher platelet transfusion threshold is unknown, but considerations include adult platelets disrupting the neonatal hemostatic balance of hypoactive platelets in a hypercoagulable and fragile environment and having a pro‐inflammatory effect.
Conventional Testing Produces Submaximal Values for Oxygen Uptake in Elite Runners
Authors: Beltrami Fernando G. , Noakes Timothy D. 
Published: March 2021

Purpose: This study aimecd to investigate whether elite athletes could reach higher values of maximal oxygen uptake () during a decremental exercise test in comparison with a traditional incremental test, as recently demonstrated in trained individuals. Methods: Nine male runners (age 25.8 [5.1] y, season best 10-km time 31:19 [1:50]) performed, on different days, 3 maximal uphill (5% grade) running exercise tests in fixed order: an incremental test (INC1), a V-shape exercise test (where speed started at 0.5 km·h−1 higher than the top stage finished during INC1 and was slowly decreased during 5.5 min, when it was again increased in similar fashion to the INC tests), and a final incremental test (INC2). Results: during the V-shape exercise test was higher than during INC1 (6.3% [3.0%], P = .01), although running speed was lower (16.6 [1.7] vs 17.9 [1.6] km·h−1, P = .01). Performance was similar between INC1 and INC2, but during INC2 was higher than INC1 (P < .001). During the V-shape exercise test, 5 participants reached the incremental part of the test, but did not increase (, P = .67), despite higher running speed (approximately 1.1 km·h−1, P < .01). Heart rate, pulmonary ventilation, breathing rate, and respiratory exchange ratio measured at were not different between tests. Conclusion: A decremental exercise test of sufficient intensity can produce higher than a traditional incremental test, even in elite athletes, and this is maintained during a subsequent incremental test.
Changes in children’s surgical services during the COVID-19 pandemic at a tertiary-level government hospital in a lower middle-income country
Authors: Farooq Md. Abdullah Al , Kabir S M Humayun , Chowdhury Tanvir Kabir , Sadia Ayesha , Alam Md. Afruzul , Farhad Tanzil 
Published: March 2021

ObjectiveThe aim of this study was to quantify the changes that occurred in the surgical services of children during the COVID-19 pandemic from the perspective of a low/middle-income country.DesignA case–control study was conducted at a large referral centre in Bangladesh among patients aged ≤12 years. Comparisons were made between cases admitted during a period of ‘April to September 2020’ (Pandemic period) and controls during a similar period in 2019 (Reference period). The number of admissions and outpatient department (OPD) attendances, age and sex distribution, diagnosis, number and types of surgeries performed (elective vs emergency), variations in treatment of acute appendicitis, types of anaesthesia and mortality were compared.ResultsAdmissions were only 41% of previous year (635 vs 1549), and OPD attendances were only 28% of previous year (603 vs 2152). Admission of children reduced by 65.8%, but neonatal admission reduced only by 7.6%. The median age of the admitted patients was significantly lower during the pandemic period (3 vs 4 years, p<0.01). Acute appendicitis (151, 9.8%) and trauma (61, 9.6%), respectively, were the the most common causes of admission during the reference and the pandemic period. Elective surgeries were only 17% and emergency surgeries were 64% of previous year (p<0.01). Appendectomy (88, 9.1%) and laparotomy (77, 17.6%), respectively, were the most common surgeries performed during the reference and the pandemic period. Conservative treatment of acute appendicitis was more during the pandemic period (47.5% vs 28.5%, p=0.01), but patients who underwent appendectomies had more complicated appendicitis (63.3% vs 42.1%, p=0.01). In all, 90.4% of surgeries were performed by resident doctors. There were no COVID-19- related deaths.ConclusionTrauma became the most common cause of admission during the pandemic, and neonatal surgical conditions remained almost unchanged with high mortality rates. Elective procedures and laparoscopy remained low and resident doctors played a major role in providing surgical services.
Moving towards a local testing solution for undetermined thyroid fine-needle aspirates: validation of a novel custom DNA-based NGS panel
Authors: Sgariglia Roberta , Nacchio Mariantonia , Migliatico Ilaria , Vigliar Elena , Malapelle Umberto , Pisapia Pasquale , De Luca Caterina , Iaccarino Antonino , Salvatore Domenico , Masone Stefania , Troncone Giancarlo , Bellevicine Claudio 
Published: March 2021

AimsIn thyroid cytopathology, the undetermined diagnostic categories still pose diagnostic challenges. Although next-generation sequencing (NGS) is a promising technique for the molecular testing of thyroid fine-needle aspiration (FNA) specimens, access to such technology can be difficult because of its prohibitive cost and lack of reimbursement in countries with universal health coverage. To overcome these issues, we developed and validated a novel custom NGS panel,Nexthyro,specifically designed to target 264 clinically relevant mutations involved in thyroid tumourigenesis. Moreover, in this study, we compared its analytical performance with that of our previous molecular testing strategy.MethodsThe panel, which includes 15 genes (BRAF, EIF1AX, GNAS, HRAS, IDH1, KRAS, NF2, NRAS, PIK3CA, PPM1D, PTEN, RET, DICER1, CHEK2, TERT promoter),was validated with a cell-line derived reference standard and 72 FNA archival samples previously tested with the 7-gene test.ResultsNexthyroyielded 100% specificity and detected mutant alleles at levels as low as 2%. Moreover, in 5/72 (7%) FNAs, it detected more clinically relevant mutations inBRAFandRASgenes compared with the 7-gene test.Nexthyroalso revealed better postsequencing metrics than the previously adopted commercial ‘generic’ NGS panel.ConclusionOur comparative analysis indicates thatNexthyrois a reliable NGS panel. The study also implies that a custom-based solution for routine thyroid FNA is sustainable at the local level, allowing patients with undetermined thyroid nodules affordable access to NGS.
The Impact of Traumatic Brain Injury on Neurocognitive Outcomes in Children: a Systematic Review and Meta-Analysis
Authors: Goh Mark Sen Liang , Looi Dawn Shu Hui , Goh Jia Ling , Sultana Rehena , Goh Sharon Si Min , Lee Jan Hau , Chong Shu-Ling 
Published: March 2021

ObjectiveTo assess the burden of paediatric traumatic brain injury (TBI) on neurocognition via a systematic review and meta-analysis.MethodsStudies that compared neurocognitive outcomes of paediatric patients with TBI and controls were searched using Medline, Embase, PsycINFO and Cochrane Central Register of Controlled Trials, between January 1988 and August 2019. We presented a random-effects model, stratified by TBI severity, time of assessment post injury and age.ResultsOf 5919 studies, 41 (patients=3717) and 33 (patients=3118) studies were included for the systematic review and meta-analysis, respectively. Studies mostly measured mild TBI (n=26, patients=2888) at 0–3 months postinjury (n=17, patients=2502). At 0–3 months postinjury, standardised mean differences between TBI and controls for executive function were −0.04 (95% CI −0.14 to 0.07; I2=0.00%), −0.18 (95% CI −0.29 to –0.06; I2=26.1%) and −0.95 (95% CI −1.12 to –0.77; I2=10.1%) for mild, moderate and severe TBI, respectively; a similar effect was demonstrated for learning and memory. Severe TBI had the worst outcomes across all domains and persisted >24 months postinjury. Commonly used domains differed largely from workgroup recommendations. Risk of bias was acceptable for all included studies.ConclusionA dose-dependent relationship between TBI severity and neurocognitive outcomes was evident in executive function and in learning and memory. Cognitive deficits were present for TBIs of all severity but persisted among children with severe TBI. The heterogeneity of neurocognitive scales makes direct comparison between studies difficult. Future research into lesser explored domains and a more detailed assessment of neurocognitive deficits in young children are required to better understand the true burden of paediatric TBI.
Occupations and exposure events in acute and subacute irritant-induced asthma
Authors: Lindström Irmeli , Lantto Jussi , Karvala Kirsi , Soini Satu , Ylinen Katriina , Suojalehto Hille , Suuronen Katri 
Published: March 2021

BackgroundExposures leading to irritant-induced asthma (IIA) are poorly documented.MethodsWe retrospectively screened the medical records of patients with IIA diagnosed in an occupational medicine clinic during 2000–2018. We classified the cases into acute (onset after single exposure) and subacute (onset after multiple exposures) IIA. We analysed in detail, occupations, causative agents and their air levels in the workplace, exposure events and the root causes of high exposure.ResultsAltogether 69 patients were diagnosed with IIA, 30 with acute and 39 with subacute IIA. The most common occupational groups were industrial operators (n=23, 33%), metal and machinery workers (n=16, 11%) and construction workers (n=12, 8%). Among industrial operators significantly more cases had subacute IIA than acute IIA (p=0.002). Forty cases (57%) were attributable to some type of corrosive acidic or alkaline chemical. Acute IIA followed accidents at work in different types of occupation, while subacute IIA was typical among industrial operators performing their normal work tasks under poor work hygiene conditions. The most common root cause was lack of information or false guidance in acute IIA (n=11, 36%) and neglect of workplace hygiene measures in subacute IIA (n=29, 74%).ConclusionsAccidents are the main causes of acute IIA, whereas subacute IIA can develop in normal work in risk trades with poor work hygiene. Airborne strong acids or bases seem to be the most important causative agents of acute and subacute IIA. The different risk profiles of acute and subacute IIA should be considered in the prevention and identification of the cases.
Cross-sectional analysis of hospital tasks handed over to general practitioners: workload delegation or dumping?
Authors: Mughal Zahir , Maharjan Rajib 
Published: March 2021

AbstractPurpose of the studyNew requirements for hospital clinicians to follow up and act on hospital-initiated investigations were introduced in 2016 in the National Health Service standard contract. We aimed to evaluate the tasks handed over from hospital clinicians to general practitioners (GPs).Study designA retrospective observation of all tasks in a random sample of electronic discharge summaries at a university teaching hospital over a 1 month period was conducted. A single-best-answer questionnaire was circulated among hospital clinicians over 3 months to gain an understanding of their follow-up and referral practices.ResultsThe total number of tasks found on discharge summaries (n=178) were 227, of which 39% were directed at GPs and 61% at the hospital team. Of 89 tasks delegated to GPs, 33% were inappropriate. Some tasks on discharge summaries were delegated more frequently to GPs such as blood tests (73%) and endoscopy requests (67%). While others were undertaken more often by hospitals clinicians including imaging requests (88%), follow-up appointments (87%) and onward referrals (71%). Surveyed doctors (n=72) admitted to asking GPs to follow up blood tests (52%), imaging and endoscopy (16%) and make onward referrals for related conditions (14%) and unrelated conditions (70%).ConclusionThe majority of outstanding tasks in the hospital setting were followed up by hospital clinicians. A considerable volume of tasks were delegated to GPs, of which a significant proportion were inappropriate. An increase in awareness and understanding among hospital clinicians of their responsibility to follow up hospital-initiated investigations is needed.
Epidemiology and prognostic factors of pleural empyema
Authors: Bobbio Antonio , Bouam Samir , Frenkiel Jerome , Zarca Kevin , Fournel Ludovic , Canny Emelyne , Icard Philippe , Porcher Raphaël , Alifano Marco 
Published: March 2021

BackgroundInfection of the pleural cavity invariably leads to hospitalisation, and a fatal outcome is not uncommon. Our aim was to study the epidemiology of pleural empyema on a nationwide basis in the whole population and in three subgroups of patients, namely post-lung resection, associated cancer and those with no surgery and no cancer.MethodsData from patients aged ≥18 years hospitalised with a diagnosis of pleural infection in France between January 2013 and December 2017 were retrieved from the medical-administrative national hospitalisation database and retrospectively analysed. Mortality, length of stay and costs were assessed.ResultsThere were 25 512 hospitalisations for pleural empyema. The annual rate was 7.15 cases per 100 000 habitants in 2013 and increased to 7.75 cases per 100 000 inhabitants in 2017. The mean age of patients was 62.4±15.6 years and 71.7% were men. Post-lung resection, associated cancer and no surgery–no cancer cases accounted for 9.8%, 30.1% and 60.1% of patients, respectively. These groups were significantly different in terms of clinical characteristics, mortality and risk factors for length of stay, costs and mortality. Mortality was 17.1% in the whole population, 29.5% in the associated cancer group, 17.7% in the post-lung resection group and 10.7% in the no surgery–no cancer group. In the whole population, age, presence of fistula, higher Charlson Comorbidity Index (>3), alcohol abuse, arterial hypertension, hyperlipidaemia, atheroma, atrial fibrillation, performance status >3 and three subgroups of pleural empyema independently predicted mortality.ConclusionsEmpyema is increasing in incidence. Factors associated with mortality are recent lung resection and associated diagnosis of cancer.
Asymptotic dimension and coarse embeddings in the quantum setting
Authors: Chávez-Domínguez Javier Alejandro , Swift Andrew T. 
Published: March 2021

We generalize the notions of asymptotic dimension and coarse embeddings from metric spaces to quantum metric spaces in the sense of Kuperberg and Weaver [A von Neumann algebra approach to quantum metrics, Mem. Am. Math. Soc. 215(1010) (2012) 1–80]. We show that quantum asymptotic dimension behaves well with respect to metric quotients and direct sums, and is preserved under quantum coarse embeddings. Moreover, we prove that a quantum metric space that equi-coarsely contains a sequence of expanders must have infinite asymptotic dimension. This is done by proving a quantum version of a vertex-isoperimetric inequality for expanders, based upon a previously known edge-isoperimetric one from [K. Temme, M. J. Kastoryano, M. B. Ruskai, M. M. Wolf and F. Verstraete, The [Formula: see text]-divergence and mixing times of quantum Markov processes, J. Math. Phys. 51(12) (2010) 122201].
Cost‐Effectiveness of Coronary Artery Bypass Grafting and Percutaneous Coronary Intervention in Patients With Chronic Kidney Disease and Acute Coronary Syndromes in the US Medicare Program
Authors: Reynolds Matthew R. , Gong Tingting , Li Shuling , Herzog Charles A. , Charytan David M. 
Published: March 2021

Background
Coronary revascularization provides important long‐term clinical benefits to patients with high‐risk presentations of coronary artery disease, including those with chronic kidney disease. The cost‐effectiveness of coronary interventions in this setting is not known.

Methods and Results
We developed a Markov cohort simulation model to assess the cost‐effectiveness of percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) in patients with chronic kidney disease who were hospitalized with acute myocardial infarction or unstable angina. Model inputs were primarily drawn from a sample of 14 300 patients identified using the Medicare 20% sample. Survival, quality‐adjusted life‐years, costs, and cost‐effectiveness were projected over a 20‐year time horizon. Multivariable models indicated higher 30‐day mortality and end‐stage renal disease with both PCI and CABG, and higher stroke with CABG, relative to medical therapy. However, the model projected long‐term gains of 0.72 quality‐adjusted life‐years (0.97 life‐years) for PCI compared with medical therapy, and 0.93 quality‐adjusted life‐years (1.32 life‐years) for CABG compared with PCI. Incorporation of long‐term costs resulted in incremental cost‐effectiveness ratios of $65 326 per quality‐adjusted life‐year gained for PCI versus medical therapy, and $101 565 for CABG versus PCI. Results were robust to changes in input parameters but strongly influenced by the background costs of the population, and the time horizon.

Conclusions
For patients with chronic kidney disease and high‐risk coronary artery disease presentations, PCI and CABG were both associated with markedly increased costs as well as gains in quality‐adjusted life expectancy, with incremental cost‐effectiveness ratios indicating intermediate value in health economic terms.
Prefrontal Lesions Disrupt Posterior Alpha–Gamma Coordination of Visual Working Memory Representations
Authors: Davoudi Saeideh , Parto Dezfouli Mohsen , Knight Robert T. , Daliri Mohammad Reza , Johnson Elizabeth L. 
Published: March 2021

AbstractHow does the human brain prioritize different visual representations in working memory (WM)? Here, we define the oscillatory mechanisms supporting selection of “where” and “when” features from visual WM storage and investigate the role of pFC in feature selection. Fourteen individuals with lateral pFC damage and 20 healthy controls performed a visuospatial WM task while EEG was recorded. On each trial, two shapes were presented sequentially in a top/bottom spatial orientation. A retro-cue presented mid-delay prompted which of the two shapes had been in either the top/bottom spatial position or first/second temporal position. We found that cross-frequency coupling between parieto-occipital alpha (α; 8–12 Hz) oscillations and topographically distributed gamma (γ; 30–50 Hz) activity tracked selection of the distinct cued feature in controls. This signature of feature selection was disrupted in patients with pFC lesions, despite intact α–γ coupling independent of feature selection. These findings reveal a pFC-dependent parieto-occipital α–γ mechanism for the rapid selection of visual WM representations.
The Prospective Sleeping Brain: Age-Related Differences in Episodic Future Thinking and Frontal Sleep Spindles
Authors: Fillmore Paul , Gao Chenlu , Diaz Jose , Scullin Michael K. 
Published: March 2021

Abstract
Sleep spindles are a physiological marker of off-line memory consolidation. In young adults, sleep spindles are preferentially responsive to encoded information that is tagged as having future relevance. Older adults, on the other hand, show reduced capacity for future simulation and alterations in sleep physiology. Healthy young adults (n = 38) and older adults (n = 28) completed an adaptation night, followed by two in-laboratory polysomnography nights, in which they mentally simulated future events or remembered past events, recorded via written descriptions. We quantified the degree of future/past thinking using linguistic analysis of time orientation. In young adults, greater future thinking was linked to greater spindle density, even when controlling for gender, age, and word count (rp = .370, p = .028). The opposite was true for older adults, such that greater future thinking was associated with reduced spindle density (rp = −.431, p = .031). These patterns were selective to future thinking (not observed for past thinking). The collective findings implicate an impaired interaction between future relevance tagging and sleep physiology as a mechanism by which aging compromises sleep-dependent cognitive processing.