CLINICAL COURSE AND DISEASE OUTCOME IN COVID-19 PATIENTS WITH DIABETES MELLITUS
Authors: Baljic Rusmir , Velic Ahmed , Muhic Amila , Gojak Refet , Gazibera Belma , Bajramovic Nermina , Hadzovic– Cengic Meliha , Huric Ilhama 
Published: May 2021

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) whose pandemic was declared on March 11 2021 (1). Spectrum of COVID-19 clinical manifestations is very wide. Most patients report to ambulance with mild or moderate symptoms, but some of them rapidly develops acute respiratory distress syndrome (ARDS), respiratory failure, acute cardiac injury, multiple organ failure and death (2). Older age, diabetes mellitus and cardiovascular disease are reported as high predictors of morbidity and mortality.
Aim: To determine correlation between diabetes mellitus and severity of clinical picture in patients with COVID-19.
Methods: Current study involve retrospective analysis of 1513 patients with Real Time PCR confirmed COVID-19 hospitalized in Clinic for infectious disease, University Clinical Center, Sarajevo, Bosnia and Herzegovina, in a period of June 2020 to December 2020.
Results: Among them 417 had previously diagnosed of diabetes mellitus. Results show that patients with diabetes mellitus are likely to require treatment in Intensive care unit, and oxygenic support with invasive ventilation. There was no statistically significant difference in outcome of the disease.
Conclusion: Even this study didn’t find increased mortality in patients with COVID-19 and diabetes mellitus, further studies should be done to determine risk for patients with DM to develop severe form of disease.

Peer Review History:
Received 23 March 2021; Revised 17 April; Accepted 5 May, Available online 15 May 2021
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Received file: Reviewer's Comments:
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.5/10
Reviewer(s) detail:
Dr. Branislav Ranković,
University of Kragujevac, Serbia, rankovic@kg.ac.rs
Dr. Poualeu Kamani Sylviane Laure,
University of Dschang, Cameroon, poualeusylviane@yahoo.fr
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