bluuebunny/crossref_metadata_2025_split huggingface dataset:
How is the COVID-19 pandemic affecting women's menstrual cycles and quality of life? A view from South Asia
Authors: Hashmi Nida , Ullah Irfan , Tariq Syeda Rida , de Filippis Renato , Orsolini Laura , Pinto da Costa Mariana , Virani Sanya , Pereira-Sanchez Victor 
Published: November 2021

SUMMARYThe substantial strain that women are facing during the COVID-19 pandemic can affect their menstrual cycle and further impair their quality of life. In low- and middle-income countries, this strain is exacerbated by: cultural taboos and poor education related to menstruation; ‘period poverty’; unavailability of menstrual hygiene products; and poor hygiene facilities. We suggest actions that governments, healthcare professionals and individuals can take to address these factors and minimise the psychological impact of COVID-19 on women's physical and mental health.
TP53 Gain-of-Function and Non–Gain-of-Function Mutations Are Differentially Associated With Sidedness-Dependent Prognosis in Metastatic Colorectal Cancer
Authors: Pan Minggui , Jiang Chen , Tse Pam , Achacoso Ninah , Alexeeff Stacey , Solorzano Aleyda V. , Chung Elaine , Hu Wenwei , Truong Thach-Giao , Arora Amit , Sundaresan Tilak , Suga Jennifer Marie , Thomas Sachdev , Habel Laurel A. 
Published: November 2021

PURPOSE To examine the association of gain-of-function (GOF) and non–gain-of-function (non-GOF) TP53 mutations with prognosis of metastatic right-sided (RCC) versus left-sided colorectal cancer (LCC). METHODS This cohort study included patients with metastatic colorectal cancer (CRC) who had next-generation sequencing performed from November 2017 to January 2021. We defined R175H, R248W, R248Q, R249S, R273H, R273L, and R282W as GOF and all other mutp53 as non-GOF. We used Cox regression modeling to examine the association between GOF and non-GOF mutp53 and overall survival (OS), adjusting for age, sex, ethnicity, performance status, Charlson comorbidity index and receipt of chemotherapy. RESULTS Of total 1,043 patients, 735 had tumors with mutp53 and 308 had wild-type p53 (wtp53). GOF was associated with worse OS than non-GOF mutp53 only in LCC (hazard ratio [HR] = 1.66 [95% CI, 1.20 to 2.29]), but not in RCC (HR = 0.79 [95% CI, 0.49 to 1.26]). Importantly, RCC was associated with worse OS than LCC only in the subset of patients whose CRC carried non-GOF (HR = 1.76 [95% CI, 1.30 to 2.39]), but not GOF mutp53 (HR = 0.92 [95% CI, 0.55 to 1.53]) or wtp53 (HR = 0.88 [95% CI, 0.60 to 1.28]). These associations were largely unchanged after also adjusting for RAS, BRAF, and PIK3CA mutations, and microsatellite instability-high. CONCLUSION Poorer survival of patients with metastatic RCC versus LCC appeared to be restricted to the subset with non-GOF mutp53, whereas GOF versus non-GOF mutp53 was associated with poorer survival only among patients with LCC. This approach of collectively classifying mutp53 into GOF and non-GOF provides new insight for prognostic stratification and for understanding the mechanism of sidedness-dependent prognosis. If confirmed, future CRC clinical trials may benefit from incorporating this approach.
Identification and generation of different statistical distributions of light using Gamma modeling
Authors: Zhang Shuanghao , Zheng Huaibin , Wang Gao , Chen Hui , He Yuchen , Luo Sheng , Liu Jianbin , Zhou Yu , Li Fuli , Xu Zhuo 
Published: November 2021

Abstract
Correlation measurement or calculation is typically used to classify the antibunched, bunched, or superbunched light with the degree of second-order coherence. However, it cannot characterize and identify the statistical distribution type of light. Since the statistical distributions of many classical light sources can be characterized by the generalized Gamma distribution, here we propose a new method to directly identify and generate classical light with different correlation properties by Gamma modeling from statistics rather than correlation. Experimental verification of beams from a four-wave mixing process agrees with this method, and the influences of temperature and laser detuning on the measured results are investigated. The proposal demonstrates an efficient approach to classifying and identifying classical light sources using Gamma modeling. More importantly, it can flexibly design and generate the required correlated lights meeting various optical applications according to the presented rules.
Fictitious Meals, Culinary Constraints: The Recipe Form in Four Oulipian Texts
Authors: Joensuu Juri 
Published: November 2021

AbstractThis article looks into fictitious meals and the use of culinary recipe form in experimental and procedural literature, namely, works of constrained writing associated with OuLiPo (Ouvroir de Littérature Potentielle). The recipe form is first scrutinized from the procedural, structural, and historical viewpoints, also concerning its lesser-known imaginative and esoteric genealogy. In addition, its connections to the notions of narrativity and fiction are discussed. The recipe's relationship to action is depicted by a simple procedural model. There is a metaphorical and conceptual, but also formal and operational, similarity between the coded procedures of cooking and writing. A recipe is a procedure, a script for an infinity of possible meals, and a literary procedure is a recipe for writing. It is not surprising, then, that Oulipian writers have utilized the recipe form in their food-related works. Four such literary recipes (by Georges Perec, Jacques Roubaud, Harry Mathews, and Alastair Brotchie) are closely examined, after discussion of key concepts of Oulipian poetics from the culinary viewpoint. The article's special point of reference is the parodic, satirical, absurd, and other humorous meanings that literary recipes often seem to produce, which is linked to the operational and structural dimensions of the recipe—its comically posited procedural form.
Riddles inJin Ping Mei
Authors: Kelly Thomas 
Published: November 2021

AbstractJin Ping Mei cihua 金瓶梅詞話 (Plum in the Golden Vase) displays an unprecedented interest in breaking apart and reassembling the components of words. This essay asks where the Cihua edition's fascination with character manipulation (a procedure the author refers to as chaibai daozi 拆白道字) comes from and how it relates to literary riddles that precede and follow this landmark sixteenth-century novel. Jin Ping Mei cihua enlarges the presentation and associations of riddles in fiction through its engagement with contemporaneous theatrical literature and the entertainment culture of the brothel. Later commentators, notably Zhang Zhupo 張竹坡 (1670–1698), reorganize the game sequences within which bouts of character manipulation are embedded for the purposes of narrative prolepsis and character development, advocating an approach to reading enigmas as portents that influenced late imperial novelists. In doing so, however, they efface the Cihua's unruly celebration of contingency, the novel's seductive insinuation that it might be written otherwise.
The Textual Architecture of Empire in Two Early Qing Anthologies
Authors: Moyer Jessica Dvorak 
Published: November 2021

Abstract
During the first half century of the Qing dynasty, Manchu emperors commissioned massive publication projects on the Chinese classics. In early Qing interpretations of classics on the family, negotiations between Manchu and Han family and gender norms furthered the empire-building project. This article compares the spatial form of the Yuding Nei ze yanyi 御定内則衍義 (1656), an expansion of the “Inner Standards” chapter of the Classic of Rites commissioned by the Shunzhi emperor, to that of the Yuding Xiao jing yanyi 御定孝經衍義 (1682), an expansion of the Classic of Filial Piety commissioned by the Kangxi emperor. These works are textual spaces where the cultural and political negotiations of the early Qing empire play out; they use spatial strategies of juxtaposition and hierarchy to balance different messages for different constituencies, creating textual models of empire.
Unfinished Revolutions
Authors: Tan Li Wen Jessica 
Published: November 2021

AbstractThis article examines Wei Beihua's modernist works, which have receded into the shadows of Sinophone Malayan (Mahua) literary history, in relation to Indonesian poet Chairil Anwar, to excavate a neglected route of transculturation at the height of Southeast Asia's nationalist movements during the 1950s. Unlike Anwar's modernist poems that thrive in Indonesia, Wei Beihua's works were considered outliers during a period when realist literature was deemed an effective tool for social mobilization in postwar Malaya. Nonetheless, it is critical for us to recognize that Wei Beihua did not reject realism or underestimate the role of literature in nation building. This article argues that Wei Beihua's idea of modernism is premised on an artist's affective and self-reflexive engagement with realism, which gives rise to a dialectical tension. The tension between his advocacy of an artist's individualism, which is inspired by Anwar, and the impetus of responding to nationalism manifests in his meta-fictional short stories that reflect on the varying motivations behind art creation. His works offer a productive perspective to reconsider the modernist artist's role during revolution and “the limits of realism” of revolutionary works when art was deemed integral to nation building in postwar Southeast Asia.
A new method to localise and quantify oxidative stress in live juvenile mussels
Authors: Delorme Natalí J. , Schmidt Alfonso J. , Zamora Leonardo N. , Burritt David J. , Ragg Norman L. C. 
Published: November 2021

ABSTRACT
Stress and survival of the juvenile New Zealand green-lipped mussel, Perna canaliculus, is a poorly understood bottleneck in the ecological and economic performance of a significant aquaculture crop. This species was therefore selected as a model organism for the development of a new method to quantify oxidative stress in whole individuals. An in vivo ROS-activated stain (CellROX™) was administered to anaesthetised, translucent juveniles that were subsequently formaldehyde fixed and then visualised using confocal microscopy. Subsequent application of image analysis to quantifying ROS-positive tissue areas was successfully used to detect stress differences in juvenile mussels exposed to varying levels of emersion. This integrated method can be used to localise and quantify ROS production in individual translucent bivalve life stages (larval and juvenile), while relative stability following fixation greatly expands potential practical field applications.
This article has an associated First Person interview with the first and third authors of the paper.
Novel patient-derived models of desmoplastic small round cell tumor confirm a targetable dependency on ERBB signaling
Authors: Smith Roger S. , Odintsov Igor , Liu Zebing , Lui Allan Jo-Weng , Hayashi Takuo , Vojnic Morana , Suehara Yoshiyuki , Delasos Lukas , Mattar Marissa S. , Hmeljak Julija , Ramirez Hillary A. , Shaw Melissa , Bui Gabrielle , Hartono Alifiani B. , Gladstone Eric , Kunte Siddharth , Magnan Heather , Khodos Inna , De Stanchina Elisa , La Quaglia Michael P. , Yao Jinjuan , Laé Marick , Lee Sean B. , Spraggon Lee , Pratilas Christine A. , Ladanyi Marc , Somwar Romel 
Published: November 2021

ABSTRACT
Desmoplastic small round cell tumor (DSRCT) is characterized by the t(11;22)(p13;q12) translocation, which fuses the transcriptional regulatory domain of EWSR1 with the DNA-binding domain of WT1, resulting in the oncogenic EWSR1-WT1 fusion protein. The paucity of DSRCT disease models has hampered preclinical therapeutic studies on this aggressive cancer. Here, we developed preclinical disease models and mined DSRCT expression profiles to identify genetic vulnerabilities that could be leveraged for new therapies. We describe four DSRCT cell lines and one patient-derived xenograft model. Transcriptomic, proteomic and biochemical profiling showed evidence of activation of the ERBB pathway. Ectopic expression of EWSR1-WT1 resulted in upregulation of ERRB family ligands. Treatment of DSRCT cell lines with ERBB ligands resulted in activation of EGFR, ERBB2, ERK1/2 and AKT, and stimulation of cell growth. Antagonizing EGFR function with shRNAs, small-molecule inhibitors (afatinib, neratinib) or an anti-EGFR antibody (cetuximab) inhibited proliferation of DSRCT cells. Finally, treatment of mice bearing DSRCT xenografts with a combination of cetuximab and afatinib significantly reduced tumor growth. These data provide a rationale for evaluating EGFR antagonists in patients with DSRCT.
This article has an associated First Person interview with the first two authors of the paper.
The rat rotenone model reproduces the abnormal pattern of central catecholamine metabolism found in Parkinson's disease
Authors: Landau Regev , Halperin Reut , Sullivan Patti , Zibly Zion , Leibowitz Avshalom , Goldstein David S. , Sharabi Yehonatan 
Published: November 2021

ABSTRACT
Recent reports indicate that Parkinson's disease (PD) involves specific functional abnormalities in residual neurons – decreased vesicular sequestration of cytoplasmic catecholamines via the vesicular monoamine transporter (VMAT) and decreased aldehyde dehydrogenase (ALDH) activity. This double hit builds up the autotoxic metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL), the focus of the catecholaldehyde hypothesis for the pathogenesis of PD. An animal model is needed that reproduces this abnormal catecholamine neurochemical pattern. Adult rats received subcutaneous vehicle or the mitochondrial complex 1 inhibitor rotenone (2 mg/kg/day via a minipump) for 10 days. Locomotor activity was recorded, and striatal tissue sampled for catechol contents and catechol ratios that indicate the above abnormalities. Compared to vehicle, rotenone reduced locomotor activity (P=0.002), decreased tissue dopamine concentrations (P=0.00001), reduced indices of vesicular sequestration (3,4-dihydroxyphenylacetic acid (DOPAC)/dopamine) and ALDH activity (DOPAC/DOPAL) (P=0.0025, P=0.036), and increased DOPAL levels (P=0.04). The rat rotenone model involves functional abnormalities in catecholaminergic neurons that replicate the pattern found in PD putamen. These include a vesicular storage defect, decreased ALDH activity and DOPAL build-up. The rat rotenone model provides a suitable in vivo platform for studying the catecholaldehyde hypothesis.
Intrinsic and damage-induced JAK/STAT signaling regulate developmental timing by the Drosophila prothoracic gland
Authors: Cao Xueya , Rojas Marta , Pastor-Pareja José Carlos 
Published: November 2021

ABSTRACT
Development involves tightly paced, reproducible sequences of events, yet it must adjust to conditions external to it, such as resource availability and organismal damage. A major mediator of damage-induced immune responses in vertebrates and insects is JAK/STAT signaling. At the same time, JAK/STAT activation by the Drosophila Upd cytokines is pleiotropically involved in normal development of multiple organs. Whether inflammatory and developmental JAK/STAT roles intersect is unknown. Here, we show that JAK/STAT is active during development of the prothoracic gland (PG), which controls metamorphosis onset through ecdysone production. Reducing JAK/STAT signaling decreased PG size and advanced metamorphosis. Conversely, JAK/STAT hyperactivation by overexpression of pathway components or SUMOylation loss caused PG hypertrophy and metamorphosis delay. Tissue damage and tumors, known to secrete Upd cytokines, also activated JAK/STAT in the PG and delayed metamorphosis, at least in part by inducing expression of the JAK/STAT target Apontic. JAK/STAT damage signaling, therefore, regulates metamorphosis onset by co-opting its developmental role in the PG. Our findings in Drosophila provide insights on how systemic effects of damage and cancer can interfere with hormonally controlled development and developmental transitions.
Insulin at 100 years – is rebalancing its action key to fighting obesity-related disease?
Authors: Brierley Gemma V. , Semple Robert K. 
Published: November 2021

ABSTRACT
One hundred years ago, insulin was purified and administered to people with diabetes to lower blood glucose, suppress ketogenesis and save lives. A century later, insulin resistance (IR) lies at the heart of the obesity-related disease pandemic. Multiple observations attest that IR syndrome is an amalgamation of gain and loss of insulin action, suggesting that IR is a misnomer. This misapprehension is reinforced by shortcomings in common model systems and is particularly pronounced for the tissue growth disorders associated with IR. It is necessary to move away from conceptualisation of IR as a pure state of impaired insulin action and to appreciate that, in the long term, insulin can harm as well as cure. The mixed state of gain and loss of insulin action, and its relationship to perturbed insulin-like growth factor (IGF) action, should be interrogated more fully in models recapitulating human disease. Only then may the potential of rebalancing insulin action, rather than simply increasing global insulin signalling, finally be appreciated.
The perspectives of patients and their caregivers on self-management interventions for chronic conditions: a protocol for a mixed-methods overview
Authors: Niño de Guzmán Ena , Martínez García Laura , González Ana I. , Heijmans Monique , Huaringa Jorge , Immonen Kaisa , Ninov Lyudmil , Orrego-Villagrán Carola , Pérez-Bracchiglione Javier , Salas-Gama Karla , Viteri-García Andrés , Alonso-Coello Pablo 
Published: November 2021

Introduction: Self-management (SM) interventions are complex interventions and one of the main components of high-quality chronic disease care for which the incorporation of the perspectives of patients and their informal caregivers is crucial. We aim to identify, appraise and synthesise the evidence exploring patients’ and caregivers’ perspectives on SM interventions. More precisely, we aim to 1) describe how they value the importance of outcomes of SM interventions, and 2) identify the factors that might impact on acceptability and feasibility of SM interventions based on their preferences and experiences. Methods and analysis: We will conduct four mixed-methods overviews as part of COMPAR-EU, a European Union (EU) funded project aimed to identify the most effective and cost-effective SM interventions for chronic obstructive pulmonary disease (COPD), heart failure (HF), obesity, and type 2 diabetes mellitus (T2DM). We will search in MEDLINE, CINAHL, and PsycINFO for systematic reviews of studies addressing patients’ preferences on outcomes, or their experiences with SM alongside their disease trajectory or with SM interventions, published in English. Selection of studies and data extraction will be conducted in pairs. We will assess the overlap of studies and methodological quality. We will follow a three-step synthesis process: 1) narrative synthesis for quantitative evidence, 2) thematic synthesis for qualitative evidence, and 3) integration of findings in the interpretation phase. Additionally, we will consult on the relevance of findings with patients and their caregivers. Systematic review registration: PROSPERO CRD42019117867
From frustration to enlightenment: experiences of student exchange program awardees in Taiwan
Authors: Silalahi Wolter Parlindungan , Sitorus Friska Ria 
Published: November 2021

Background: This qualitative study investigates the experiences of international students’ exchange who faced difficulties in adjusting to their new environment. They experienced awkwardness in the use of advanced equipment from technology and in various cultural aspects. This study investigates two Indonesian students who participated for a semester at a Taiwanese university. It aims to explore the Indonesian student exchange program awardees’ experiences by examining both the obstacles and benefits of attending the Taiwanese university. Methods: This study used qualitative data analysis. Data were collected through a semi-structured interview, informal participant observations, and a set of open and closed-ended questions. Two Indonesian undergraduate students who belonged to the same major, year, and university were recruited to participate in this study. Results: Challenges and Benefits are the two major themes in this research. Challenges include: (1) Departure and journey; (2) Difficulties in settling in; (3) Inability to use technology facilities. Benefits include: (1) Meeting new people and exploring new places; and (2) 21st-century classroom environments. Conclusions: Despite the challenges that are associated with being students exchange awardee, there are vast opportunities for self-development and learning that is associated with teaching from the 21st-century classroom pedagogy.
Revisiting the Rist diagram for predicting operating conditions in blast furnaces with multiple injections
Authors: Bailera Manuel , Nakagaki Takao , Kataoka Ryoma 
Published: November 2021

Background: The Rist diagram is useful for predicting changes in blast furnaces when the operating conditions are modified. In this paper, we revisit this methodology to provide a general model with additions and corrections. The reason for this is to study a new concept proposal that combines oxygen blast furnaces with Power to Gas technology. The latter produces synthetic methane by using renewable electricity and CO2 to partly replace the fossil input in the blast furnace. Carbon is thus continuously recycled in a closed loop and geological storage is avoided. Methods: The new model is validated with three data sets corresponding to (1) an air-blown blast furnace without auxiliary injections, (2) an air-blown blast furnace with pulverized coal injection and (3) an oxygen blast furnace with top gas recycling and pulverized coal injection. The error is below 8% in all cases. Results: Assuming a 280 tHM/h oxygen blast furnace that produces 1154 kgCO2/tHM, we can reduce the CO2 emissions between 6.1% and 7.4% by coupling a 150 MW Power to Gas plant. This produces 21.8 kg/tHM of synthetic methane that replaces 22.8 kg/tHM of coke or 30.2 kg/tHM of coal. The gross energy penalization of the CO2 avoidance is 27.1 MJ/kgCO2 when coke is replaced and 22.4 MJ/kgCO2 when coal is replaced. Considering the energy content of the saved fossil fuel, and the electricity no longer consumed in the air separation unit thanks to the O2 coming from the electrolyzer, the net energy penalizations are 23.1 MJ/kgCO2 and 17.9 MJ/kgCO2, respectively. Discussion: The proposed integration has energy penalizations greater than conventional amine carbon capture (typically 3.7 – 4.8 MJ/kgCO2), but in return it could reduce the economic costs thanks to diminishing the coke/coal consumption, reducing the electricity consumption in the air separation unit, and eliminating the requirement of geological storage.