bluuebunny/crossref_metadata_2025_split huggingface dataset:
Harmonization of summaries of product characteristics (SmPCs) of drugs with the same active ingredients: an evaluation of SmPCs of the most frequently prescribed active substances
Authors: Gahr Maximilian , Connemann Bernhard J. , Muche Rainer , Zeiss René , Wolf Almuth 
Published: October 2021

Abstract
Purpose
In aut-idem or generic substitution, discrepancies between summaries of product characteristics (SmPCs) referring to the same active substance (AS) may cause difficulties regarding informed consent and medical liability. The qualitative and quantitative characteristics of such discrepancies are insufficiently studied, impeding harmonization of same-substance SmPCs and compromising safe drug treatment.

Methods
SmPCs of the one hundred most frequently prescribed ASs in Germany were analyzed for discrepancies in the presentation of indications (Inds) and contraindications (CInds). Inclusion and exclusion criteria of drugs/SmPCs were chosen according to the standards of the aut-idem substitution in Germany.

Results
According to the study protocol, we identified 1486 drugs, of which 1426 SmPCs could be obtained. 41% respectively 65% of the ASs had same-substance SmPCs that differed from the respective reference SmPC in the number of listed Inds respectively CInds. The number of listed Inds/CInds varied considerably between same-substance SmPCs with maximum ranges in Inds of 7 in amoxicillin, and in CInds of 11 in lisinopril. Many ASs had large proportions (> 50%) of associated same-substance SmPCs that differed from the respective reference SmPC. A considerable proportion of ASs had same-substance SmPCs with formal and content-related differences other than the discrepancy in the number of Inds/CInds.

Conclusion
This evaluation of same-substance SmPCs shows a clear lack of harmonization of same-substance SmPCs. Considering that generic substitution has become the rule and that physicians usually do not know which drug the patient receives in the pharmacy, these discrepancies raise several questions, that require a separate legal evaluation.
Patients with no preoperative back pain have the best outcome after lumbar disc herniation surgery
Authors: Sigmundsson Freyr Gauti , Joelson Anders , Strömqvist Fredrik 
Published: October 2021

Abstract
Purpose
Most patients with lumbar disc herniations requiring surgery have concomitant back pain. The purpose of the current study was to evaluate the outcome of surgery for lumbar disc herniations in patients with no preoperative back pain (NBP) compared to those reporting low back pain (LBP).

Methods
15,418 patients surgically treated due to LDH with primary discectomy from 1998 until 2020 were included in the study. Self-reported low back pain assessed with a numerical rating scale (NRS) was used to dichotomize the patients in two groups, patients without preoperative back pain (NBP, NRS = 0, n = 1333, 9%) and patients with preoperative low back pain (LBP, NRS > 0, n = 14,085, 91%). Patient reported outcome measures (PROMs) collected preoperatively and one-year postoperatively were used to evaluate differences in outcomes between the groups.

Results
At the one-year follow-up, 89% of the patients in the NBP group were completely pain free or much better compared with 76% in the LBP group. Significant improvement regarding leg pain was seen in all measured PROMs in both groups oneyear after surgery. In the NBP group, 13% reported clinically significant back pain (NRS difference greater than Minimally Clinical Important Difference (MICD)) at the one-year follow-up.

Conclusions
Patients without preoperative back pain are good candidates for LDH surgery. 13% of patients without preoperative back pain develop clinically significant back pain one-year after surgery.
Cyclone Komen’s aftermath: Local knowledge shows how poverty and inequalities fuel climate risk in western Myanmar
Authors: Kmoch Laura , Palm Matilda , Persson Ulf Martin , Jepsen Martin Rudbeck 
Published: October 2021

AbstractCyclones and other extreme events exert increasing pressure on South-East Asia’s societies and put smallholder farmers at risk. Here, we draw on participatory causal-diagramming workshops, interviews and survey data, to provide contextually grounded knowledge about rural communities’ exposure and vulnerability to climate-related hazards in western Myanmar. By tracing how the 2015 cyclone Komen led to a prolonged humanitarian disaster, we show that climate-related risks in this area arise from the complex interplay of households’ pre-existing vulnerabilities, persistent farming challenges, extensive disasters and cascading effects, which disparately affect lowland and upland communities. The different household strata’s dissimilar vulnerabilities vis-à-vis Komen’s impacts were rooted in the distinct exposure of their production systems to landslides and floods. Pre-existing land-access barriers, land-degradation processes, climatic stressors, agricultural pests and diseases, and chronic lack of assets and food insecurity further mediated households’ vulnerability. Relief interventions did not stop the disaster’s escalation, although this could have been achieved with early technical and material assistance to address the cyclone’s impacts on farmers’ land. Targeted aid for households facing imminent food insecurity or debt crisis could have lessened engagement in precarious coping strategies and distress migration. A diversification of households’ livelihood and land-use practices and increased redundancies of critical assets and infrastructure could help to mitigate future cyclone-triggered disasters. By demonstrating the strengths of local knowledge approaches in untangling the complex interplay of extreme events with households’ everyday vulnerabilities and agricultural land-use practices, we make a case for more contextually grounded disaster risk and climate adaptation research.
Voluntary corporate climate initiatives and regulatory threat
Authors: Ilić Dragan , Mollet Janick Christian 
Published: October 2021

AbstractDoes participation in voluntary environmental initiatives affect firm value? We take a closer look at the Chicago Climate Exchange (CCX) and the Climate Leaders (CL), two US initiatives to curb carbon emissions that were operating during a decisive regulatory event. In 2009 the Waxman-Markey Bill surprisingly passed the House of Representatives and brought the US economy a big step closer to a nationwideCO2emission trading system. With an event study we assess how the stock market valued membership in the initiatives when the likelihood ofCO2regulation unexpectedly increased. Our findings suggest that only membership in the market-based CCX was considered beneficial for a mandated carbon market. This is consistent with research that equity-based regulation through financial markets can help economies favor clean industries over dirty ones. We interpret the empirical results in a simple model. Adding earlier market reactions to the firms’ membership announcements, the model implies that the market had been betting on a mandatory emission trading system all along.
Economic costs of cigarette smoking among adolescents in Nigeria
Authors: Olumide Adesola O. , Shmueli Amir , Adebayo Emmanuel S. , Omotade Olayemi O. 
Published: October 2021

Abstract
Background
Cigarette smoking is an established cause of preventable death and often initiated during adolescence. We estimated the short- and long-term costs of cigarette smoking among currently smoking adolescents in Nigeria.

Methods
A cross-sectional survey among adolescents in Oyo state, Nigeria and a review of mortality records of patients managed for lung cancer in a tertiary facility in Ibadan, Nigeria were conducted. Short-term costs estimated were: (a) average weekly costs of purchasing cigarettes by currently smoking adolescents, and (b) costs of managing at least an episode of chronic cough occurring within 12 months of the survey. Long-term costs were limited to: (a) life-time expenditure on purchasing cigarettes, and (b) direct medical and non-medical (transportation) costs of managing lung cancer. Long-term costs were first projected to the approximate year when the adolescents (mean age:16.0 ± 1.8 years) might be diagnosed with lung cancer based on the average age at presentation with symptoms of lung cancer obtained from the records (59.8 years), and then discounted to 2020 prices. This was estimated as 44 years from the base year (2020). Costs were reported in 2020 prices in Nigerian Naira (NGN) and US dollar (USD) equivalent using the Central Bank of Nigeria, June 2020 exchange rate of USD 1: NGN 360.50.

Results
Approximately 3.8% of the adolescents were current cigarette smokers. Average weekly expenditure on cigarettes was NGN 306.82 ± 5.74 (USD 0.85 ± 0.02). About 26% had experienced at least an episode of chronic cough which cost them an average of NGN 1226.81 ± 6.18 (USD 3.40 ± 0.02) to manage. Total future costs of cigarette smoking in 2020 prices for the 43 adolescents who were current smokers in the event that they develop lung cancer were approximately NGN 175.7 million (USD 487.3 thousand), NGN 871.8 million (USD 2.4 million) and NGN 4.6 trillion (USD 12.7 million) at assumed annual inflation rates of 10%, 15%, and 20% respectively and discount rate of 4.25%.

Conclusion
The estimated economic costs of smoking were very high. Efforts to prevent smoking initiation among adolescents in our study area should be intensified. Interventions to subsidize the medical cost of health-related consequences of cigarette smoking are also required, especially as treatment costs are currently largely borne out-of-pocket.
Evaluating tree growth factors into species-specific functional soil maps for improved agroforestry system efficiency
Authors: Jiang Zhuo-Dong , Owens Phillip R. , Ashworth Amanda J. , Fuentes Bryan A. , Thomas Andrew L. , Sauer Thomas J. , Wang Qiu-Bing 
Published: October 2021

AbstractAgroforestry systems play an important role in sustainable agroecosystems. However, accurately and adequately quantifying the relationships between environmental factors and tree growth in these systems are still lacking. Objectives of this study were to quantify environmental factors affecting growth of four tree species and to develop functional soil maps (FSM) for each species in an agroforestry site. The diameter at breast height, absolute growth rate (AGR), and neighborhood competition index of 259 trees from four species (northern red oak [Quercus rubra], pecan [Carya illinoinensis], cottonwood [Populus deltoides], and sycamore [Platanus occidentalis]) were determined. A total of 51 topsoil samples were collected and analyzed, and 12 terrain attributes were derived from the digital elevation model. The relationships between AGR, soil, topography, and tree size were analyzed using Spearman correlation. Based on correlation analysis, FSM for each species were generated using the k-means cluster method by overlaying correlated soil and terrain attribute maps. Results showed tree size and terrain attributes were driving factors affecting tree growth rate relative to soil properties. The spatial variations in AGR among functional units were statistically compared within tree species and the areas with larger AGR were identified by the FSM. This study demonstrated that FSM could delineate areas with different AGR for the oak, cottonwood, and sycamore trees. The AGR of pecan trees did not vary among functional units. The generated FSM may allow land managers to more precisely establish and manage agroforestry systems.
Examining the Impact of the Golden Compass Clinical Care Program for Older People with HIV: A Qualitative Study
Authors: Tan Judy Y. , Greene Meredith , Blat Cinthia , Albers Autumn , Grochowski Janet , Oskarsson Jon , Shiels Mary , Hsue Priscilla , Havlir Diane , Gandhi Monica , Myers Janet 
Published: October 2021

AbstractThe combined burden of geriatric conditions, comorbidities, and HIV requires a model of HIV care that offers a comprehensive clinical approach with people 50 years or older with HIV. Golden Compass is an outpatient, multidisciplinary HIV-geriatrics program with an onsite HIV geriatrician, cardiologist, pharmacist, and social worker, offering specialist referrals, care navigation, and classes on improving functional status and cognition. Participants (13 patients and 11 primary care providers) were recruited using a non-probability sampling method to participate in semi-structured interviews on the perceived impact of Golden Compass on care delivered to older people with HIV. Interviews were transcribed verbatim and framework analysis used to analyze the transcripts. The perceived impacts of Golden Compass by patients and providers were organized by the Compass points (Northern: Heart and Mind, Eastern: Bones and Strength, Southern: Navigation and Network, Western: Dental, Hearing, and Vision). Overall, patients valued the focus on functional health and whole-person care, leading to greater trust in the ability of providers. Providers gained new skills through the geriatrics, cardiology and/or pharmacist consultations. The HIV-geriatrics specialty approach of Golden Compass improved functional ability and quality of life for older adults with HIV. Few integrated care programs for older people with HIV have been evaluated. This study adds to the limited literature demonstrating high patient and provider satisfaction with a HIV-care model that incorporated principles of geriatric medicine emphasizing a comprehensive approach to sustaining functional ability and improving quality of life.
Bandgaps and vibration isolation of local resonance sandwich-like plate with simply supported overhanging beam
Authors: Qiang Chenxu , Hao Yuxin , Zhang Wei , Li Jinqiang , Yang Shaowu , Cao Yuteng 
Published: October 2021

AbstractThe concept of local resonance phononic crystals proposed in recent years provides a new chance for theoretical and technical breakthroughs in the structural vibration reduction. In this paper, a novel sandwich-like plate model with local resonator to acquire specific low-frequency bandgaps is proposed. The core layer of the present local resonator is composed by the simply supported overhanging beam, linear spring and mass block, and well connected with the upper and lower surface panels. The simply supported overhanging beam is free at right end, and an additional linear spring is added at the left end. The wave equation is established based on the Hamilton principle, and the bending wave bandgap is further obtained. The theoretical results are verified by the COMSOL finite element software. The bandgaps and vibration characteristics of the local resonance sandwich-like plate are studied in detail. The factors which could have effects on the bandgap characteristics, such as the structural damping, mass of vibrator, position of vibrator, bending stiffness of the beam, and the boundary conditions of the sandwich-like plates, are analyzed. The result shows that the stopband is determined by the natural frequency of the resonator, the mass ratio of the resonator, and the surface panel. It shows that the width of bandgap is greatly affected by the damping ratio of the resonator. Finally, it can also be found that the boundary conditions can affect the isolation efficiency.
Cognitive Variables in Social Anxiety Disorder in Children and Adolescents: A Network Analysis
Authors: Vogel Felix , Reichert Julian , Hartmann Daniela , Schwenck Christina 
Published: October 2021

AbstractClark and Wells’ prominent model of social anxiety disorder (SAD) assumes that cognitive variables such as negative expectations or dysfunctional cognitions play a central role in the symptomatology of SAD. In contrast to adults, it is less clear how well the cognitive model can be applied to children and adolescents. A network analysis with seven nodes was conducted to explore the importance of cognitive variables and their interaction with symptoms of SAD based on N = 205 children and adolescents (8–18 years, M = 11.54 years). Cognitive variables had a high but differential impact within the positively connected network of SAD. Dysfunctional cognitions were most strongly connected within the network. Dysfunctional cognitions, as predicted by Clark and Wells’ model, seem to act as a hub affecting several symptoms. The association between negative expectations and avoidance indicates that negative expectations may particularly contribute to the maintenance of SAD.
Assessing Resources in a Population of Hemodialysis Patients: A New Approach to Improve Quality of Care
Authors: Bellier-Teichmann Tanja , Antonini Matteo , Delmas Philippe 
Published: October 2021

AbstractHemodialysis patients constitute a vulnerable population. Their health needs are considerable and they often present psychological symptoms such as depression and anxiety. Empirical studies have demonstrated the efficacy of positive psychology interventions to enhance the well-being of patients and alleviate their depressive symptoms. One such intervention consists in identifying and mobilizing patient resources to activate their recovery. An intervention of the sort was implemented in Switzerland with hemodialysis nurses using AERES, a novel self-assessment instrument. AERES covers 31 domains under three dimensions: personal characteristics/qualities, hobbies/passions, and social/environmental resources. The aim of this qualitative study was to explore hemodialysis nurse perceptions of the use of this instrument. Sixteen hemodialysis nurses were recruited in six hospitals in French-speaking Switzerland and interviewed after delivering the intervention. A consensual qualitative research method was used to analyze the data. Results showed that the resources instrument was easy to administer and beneficial to patients and health professionals. Patient wellbeing became the top priority for the nurses and new interventions centered on patient resources were undertaken. Quality of patient care was improved. Nurses perceived this positive psychology instrument as a means of creating a positive relationship with patients and supporting them emotionally. Assessing the resources of this vulnerable population can provide health professionals with a powerful tool to understand patient intact resources, which can be used to alleviate symptoms and foster wellbeing.
A role-game laboratory experiment on the influence of country prospects reports on investment decisions in two artificial organizational settings
Authors: Castellani Marco , Alengoz Linda , Casnici Niccolò , Squazzoni Flaminio 
Published: October 2021

AbstractThis paper investigates how reports concerning a given country’s prospects affect investment decisions in two stylized, artificial organizational settings. We designed a role-game laboratory experiment, where subjects were asked to make investment decisions for two types of fictitious companies from the same country. We found that when available reports included positive country prospects, subjects strategized more on investments regardless of the characteristics of their organization. When reports included negative prospects, however, certain organizational peculiarities influenced the subjects’ interpretations, with decision-makers opting for more prudent plans when managing a more traditional company. Cognitive maps of decision makers showed that subjects considered investment strategies as a means to fulfil a company’s role expectations regarding appropriate decisions. Notwithstanding all caveats due to the artificial and simplified nature of our experimental setting, our findings indicate the need for more research on the effect of reports and prospect analysis on strategic decisions of companies, especially when business prospects are uncertain.
Status and determinants of other gainful activities by farmers in mountainous rural regions of Gilgit-Baltistan, Pakistan
Authors: Shahzad Muhammad Abid , Ahmed Vaqar , Fischer Christian 
Published: October 2021

AbstractNon-farm income sources are important for livelihood sustenance, especially in the mountainous regions of developing countries. To implement effective policies to improve economic development, policymakers need insights at the grassroots level. Yet, there is a lack of empirical evidence in the context of Pakistan. This study examines the current situation and the factors influencing the decision by farmers to engage in other gainful activities (OGAs) such as farm diversification and off-farm work in the northern mountainous regions of Pakistan. The study is based on quantitative survey data obtained from 459 farm managers and qualitative data from 24 key informants from five different districts in Gilgit-Baltistan. Utilizing a logistic regression model, a statistical analysis is conducted on farmer and farm characteristics to investigate the probability of farm managers to engage in OGAs. The survey results show that around 71% of farm managers are engaged in OGAs (with 24% in farm diversification, 61% in offfarm work and 15% in both). The share of female farm managers is 51% in farm diversification while male farm managers dominate off-farm activities (69%). The most prevalent types of farm diversification are the processing of farm products and tourism-related farm work, while the main off-farm activities are setting up grocery stores outside the farm, having salaried jobs or engaging in other non-agricultural business. There are significant differences between farmers with and without OGAs particularly regarding farmer characteristics, agricultural income and some other variables. The logit model results show that farmer characteristics mainly determine off-farm work activities while farm (and other) characteristics mostly explain farm diversification. These findings suggest that OGAs primarily exist as livelihood strategies. Farm diversification is linked with the long-term sustenance of agricultural activities while off-farm work is predominantly driven by economic needs. Both types of OGAs require specific support policies while attention needs to be given not to threaten regional food supply.
Toward coherent O-band data center interconnects
Authors: Seiler Pascal M. , Georgieva Galina , Winzer Georg , Peczek Anna , Voigt Karsten , Lischke Stefan , Fatemi Adel , Zimmermann Lars 
Published: October 2021

AbstractUpcoming generations of coherent intra/inter data center interconnects currently lack a clear path toward a reduction of cost and power consumption, which are the driving factors for these data links. In this work, the tradeoffs associated with a transition from coherent C-band to O-band silicon photonics are addressed and evaluated. The discussion includes the fundamental components of coherent data links, namely the optical components, fiber link and transceivers. As a major component of these links, a monolithic silicon photonic BiCMOS O-band coherent receiver is evaluated for its potential performance and compared to an analogous C-band device.