bluuebunny/crossref_metadata_2025_split huggingface dataset:
The retraction of jetted slender viscoelastic liquid filaments
Authors: Sen Uddalok , Datt Charu , Segers Tim , Wijshoff Herman , Snoeijer Jacco H. , Versluis Michel , Lohse Detlef 
Published: October 2021

Long and slender liquid filaments are produced during inkjet printing, which can subsequently either retract to form a single droplet, or break up to form a primary droplet and one or more satellite droplets. These satellite droplets are undesirable since they degrade the quality and reproducibility of the print, and lead to contamination within the enclosure of the print device. Existing strategies for the suppression of satellite droplet formation include, among others, adding viscoelasticity to the ink. In the present work, we aim to improve the understanding of the role of viscoelasticity in suppressing satellite droplets in inkjet printing. We demonstrate that very dilute viscoelastic aqueous solutions ($\text {concentrations} \sim 0.003\,\%$ wt. polyethylene oxide, corresponding to nozzle Deborah number$De_{n}\sim 3$) can suppress satellite droplet formation. Furthermore, we show that, for a given driving condition, upper and lower bounds of polymer concentration exist, within which satellite droplets are suppressed. Satellite droplets are formed at concentrations below the lower bound, while jetting ceases for concentrations above the upper bound (for fixed driving conditions). Moreover, we observe that, with concentrations in between the two bounds, the filaments retract at velocities larger than the corresponding Taylor–Culick velocity for the Newtonian case. We show that this enhanced retraction velocity can be attributed to the elastic tension due to polymer stretching, which builds up during the initial jetting phase. These results shed some light on the complex interplay between inertia, capillarity and viscoelasticity for retracting liquid filaments, which is important for the stability and quality of inkjet printing of polymer solutions.
Investigation of secondary metabolites in bean cultivars and their impact on the nutritional performance ofSpodoptera littoralis(Lep.: Noctuidae)
Authors: Shishehbor Parviz , Hemmati Seyed Ali 
Published: October 2021

AbstractSpodoptera littoralis(Boisd) is globally recognized as a destructive polyphagous insect pest of various crops in the world. It is commonly managed by chemical pesticides, which can cause deleterious effects such as environmental pollution, toxicity to non-target organisms and the emergence of secondary pests. Hence, investigations into alternative pest control strategies such as the use of resistant host plant cultivar againstS. littoralisis important. This study aimed to explore the nutritional performance ofS. littoralislarvae in dependence on total anthocyanin, flavonoid, and phenol levels across 11 bean cultivars (PhaseolusandVignaspp.) under laboratory conditions. The results revealed that the Mashhad cultivar accumulated the highest amount of total phenols (13.59 mg ml−1), whereas Yaghout and Arabi cultivars posed the lowest total phenols contents (1.80 and 1.90 mg ml−1, respectively). Across larval instars (third to sixth), the highest consumption index and relative consumption rate were recorded on the Mashhad cultivar. The lowest values of efficiency of conversion of ingested food and the efficiency of conversion of digested food of total larval instars were detected in the larvae which were reared on the Mashhad cultivar. Likewise, the lowest value of the index of plant quality (IPQ) was obtained in the Mashhad cultivar; however, IPQ was figured out at the highest level in the Arabi cultivar. Our findings show that the differential accumulation of secondary metabolites would change the nutritional quality of plants forS. littoralis. Based on the findings, the Mashhad cultivar may serve as a candidate for either integrated pest management or breeding programs aiming at controlling this pest.
Intranasal corticosteroid and oxymetazoline for chronic rhinitis: a systematic review
Authors: Neighbors C L , Salvador C Fernandez , Zhu B , Camacho M , Tsai P 
Published: October 2021

AbstractObjectiveThis study aimed to summarise the evidence for efficacy of combination treatment of intranasal corticosteroid spray with oxymetazoline hydrochloride nasal spray for chronic rhinitis.MethodNine databases were systematically searched from study inception in September 2016 to 1 June 2020. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement was followed.ResultsA total of 130 studies were screened, and 4 randomised controlled trials comprising 838 patients met inclusion criteria. The study found superior improvement of nasal congestion from onset of treatment to completion in intranasal corticosteroid spray and oxymetazoline hydrochloride groups compared with control groups. Intranasal corticosteroid spray and oxymetazoline hydrochloride use resulted in higher nasal volume (standard error of mean 1, 15.8 + 1.1 ml; p < .03) compared with either placebo (12.1 + 0.9 ml) or oxymetazoline hydrochloride (12.4 + 0.8 ml) alone (p = 0.003).ConclusionIntranasal corticosteroid spray and oxymetazoline hydrochloride combination treatment may be superior in reducing rhinitis symptoms compared with either intranasal corticosteroid spray or oxymetazoline hydrochloride alone, without inducing rhinitis medicamentosa.
Relapse risk revealed by degree centrality and cluster analysis in heroin addicts undergoing methadone maintenance treatment
Authors: Wang Lei , Hu Feng , Li Wei , Li Qiang , Li Yongbin , Zhu Jia , Wei Xuan , Yang Jian , Guo Jianxin , Qin Yue , Shi Hong , Wang Wei , Wang Yarong 
Published: October 2021

AbstractBackgroundBased on hubs of neural circuits associated with addiction and their degree centrality (DC), this study aimed to construct the addiction-related brain networks for patients diagnosed with heroin dependence undertaking stable methadone maintenance treatment (MMT) and further prospectively identify the ones at high risk for relapse with cluster analysis.MethodsSixty-two male MMT patients and 30 matched healthy controls (HC) underwent brain resting-state functional MRI data acquisition. The patients received 26-month follow-up for the monthly illegal-drug-use information. Ten addiction-related hubs were chosen to construct a user-defined network for the patients. Then the networks were discriminated with K-means-clustering-algorithm into different groups and followed by comparative analysis to the groups and HC. Regression analysis was used to investigate the brain regions significantly contributed to relapse.ResultsSixty MMT patients were classified into two groups according to their brain-network patterns calculated by the best clustering-number-K. The two groups had no difference in the demographic, psychological indicators and clinical information except relapse rate and total heroin consumption. The group with high-relapse had a wider range of DC changes in the cortical−striatal−thalamic circuit relative to HC and a reduced DC in the mesocorticolimbic circuit relative to the low-relapse group. DC activity in NAc, vACC, hippocampus and amygdala were closely related with relapse.ConclusionMMT patients can be identified and classified into two subgroups with significantly different relapse rates by defining distinct brain-network patterns even if we are blind to their relapse outcomes in advance. This may provide a new strategy to optimize MMT.
Vertical zonation of benthic invertebrates in the intertidal zone of Antarctica (Admiralty Bay, King George Island)
Authors: Chelchowski Maciej , Balazy Piotr , Grzelak Katarzyna , Grzelak Lukasz , Kędra Monika , Legezynska Joanna , Kuklinski Piotr 
Published: October 2021

AbstractThe Antarctic Peninsula is undergoing rapid change due to global warming, including air and water temperature increases. Fauna inhabiting the intertidal zone are particularly exposed to warming impacts, as they are subjected to high variations in both terrestrial and marine environmental settings. This study aimed to assess intertidal macrofaunal and meiofaunal biodiversity, tidal height-related assemblage structural patterns and their responses to variability in environmental parameters on King George Island. A total of 39 macrofaunal taxa were identified, with polychaetes and amphipods being the most diverse groups and gastropods, amphipods and bivalves being the most abundant. In the case of meiofauna, 16 taxa were found, mainly nematodes, copepod nauplii and harpacticoids. There was a significant decrease in the number of species, abundance and biomass for both macrofauna and meiofauna with increasing tidal height. Our investigation documented highly diverse and abundant fauna in the Antarctic intertidal zone. With its thriving life, it could serve as a perfect model system for detecting climate change impacts on local biodiversity. Therefore, we propose the Antarctic intertidal zone as a suitable habitat for monitoring these changes.
Cogent: uniqueness types and certifying compilation
Authors: O’CONNOR LIAM , CHEN ZILIN , RIZKALLAH CHRISTINE , JACKSON VINCENT , AMANI SIDNEY , KLEIN GERWIN , MURRAY TOBY , SEWELL THOMAS , KELLER GABRIELE 
Published: October 2021

Abstract
This paper presents a framework aimed at significantly reducing the cost of proving functional correctness for low-level operating systems components. The framework is designed around a new functional programming language, Cogent. A central aspect of the language is its uniqueness type system, which eliminates the need for a trusted runtime or garbage collector while still guaranteeing memory safety, a crucial property for safety and security. Moreover, it allows us to assign two semantics to the language: The first semantics is imperative, suitable for efficient C code generation, and the second is purely functional, providing a user-friendly interface for equational reasoning and verification of higher-level correctness properties. The refinement theorem connecting the two semantics allows the compiler to produce a proof via translation validation certifying the correctness of the generated C code with respect to the semantics of the Cogent source program. We have demonstrated the effectiveness of our framework for implementation and for verification through two file system implementations.
Trading Vulnerabilities: Living with Parkinson’s Disease before and after Deep Brain Stimulation
Authors: Goering Sara , Wexler Anna , Klein Eran 
Published: October 2021

AbstractImplanted medical devices—for example, cardiac defibrillators, deep brain stimulators, and insulin pumps—offer users the possibility of regaining some control over an increasingly unruly body, the opportunity to become part “cyborg” in service of addressing pressing health needs. We recognize the value and effectiveness of such devices, but call attention to what may be less clear to potential users—that their vulnerabilities may not entirely disappear but instead shift. We explore the kinds of shifting vulnerabilities experienced by people with Parkinson’s disease (PD) who receive therapeutic deep brain stimulators to help control their tremors and other symptoms of PD.
Limitations Using Neuroimaging to Reconstruct Mental State After a Crime
Authors: Vitacco Michael J. , Randolph Alynda M. , Nelson Aguiar Rebecca J. , Porter Staats Megan L. 
Published: October 2021

AbstractNeuroimaging offers great potential to clinicians and researchers for a host of mental and physical conditions. The use of imaging has been trumpeted for forensic psychiatric and psychological evaluations to allow greater insight into the relationship between the brain and behavior. The results of imaging certainly can be used to inform clinical diagnoses; however, there continue to be limitations in using neuroimaging for insanity cases due to limited scientific backing for how neuroimaging can inform retrospective evaluations of mental state. In making this case, this paper reviews the history of the insanity defense and explains how the use of neuroimaging is not an effective way of improving the reliability of insanity defense evaluations.
Nutrition education strategies to promote vegetable consumption in preschool children: the Veggies4myHeart project
Authors: Braga-Pontes Cátia , Simões-Dias Sara , Lages Marlene , Guarino Maria P , Graça Pedro 
Published: October 2021

AbstractObjective:To test the efficacy of three nutrition education strategies on the intake of different vegetables in preschool children.Design:This is an experimental study conducted in four Portuguese preschools. The intervention consisted of 20-min educational sessions, once a week, for 5 weeks, with one of the following randomised educational strategies: Portuguese Food Wheel Guide (control), digital game, storybook, storybook and reward (stickers). All groups had repeated exposure to vegetables in all sessions. A pre- and post-test were conducted to determine vegetable intake, and a 6-month follow-up was realised.Setting:Preschools of Leiria district, Portugal.Participants:A sample of 162 children aged 3 to 6 years. All eligible children attending the preschools were invited to participate.Results:All interventions tested were effective in increasing vegetable consumption both in the short and medium term, without statistically significant differences, compared to the control group. Stickers were more effective in the short term than in the medium term.Conclusions:The nutritional education strategies associated with repeated exposure tested in this study were effective in promoting vegetable consumption in preschool children. The use of stickers may be a valid strategy to promote the consumption of vegetables less recognised by children.
Influence of integrated agronomic and weed management practices on soybean canopy development and yield
Authors: Arsenijevic Nikola , DeWerff Ryan , Conley Shawn , Ruark Matthew , Werle Rodrigo 
Published: October 2021

AbstractThe role of weed suppression by the cultivated crop is often overlooked in annual row cropping systems. Agronomic practices such as planting time, row spacing, tillage and herbicide selection may influence the time of crop canopy closure. The objective of this research was to evaluate the influence of the aforementioned agronomic practices and their interaction with the adoption of an effective preemergence (PRE) soil residual herbicide program on soybean canopy closure and yield. A field experiment was conducted in 2019 and 2020 in Arlington, WI, as a 2×2×2×2 factorial in a randomized complete block design, including early (late April) and standard (late May) planting time, narrow (38 cm) and wide (76 cm) row spacing, conventional tillage and no-till, and soil-applied PRE herbicide (yes and no; flumioxazin 150 g ai ha−1 + metribuzin 449 g ai ha−1 + pyroxasulfone 190 g ai ha−1). All plots were maintained weed-free throughout the growing season. In both years, early planted soybeans reached 90% green canopy cover (T90) before (7 to 9 d difference) and yielded more (188 to 902 kg ha−1 difference) than the standard planted soybeans. Narrow-row soybeans reached T90 earlier than wide-row soybeans (4 to 7 d difference), but yield was similar between row spacing treatments. Conventional tillage resulted in a higher yield compared to a no-till system (377 kg ha−1 difference). The PRE herbicide slightly delayed T90 (4 d or less) but had no impact on yield. All practices investigated herein influenced the time of soybean canopy closure but only planting time and tillage impacted yield. Planting soybeans earlier and reducing their row spacing expedites the time to canopy closure. The potential delay in canopy development and yield loss if soybeans are allowed to compete with weeds early in the season would likely outweigh the slight delay in canopy development by an effective PRE herbicide.
Downhole Distributed Acoustic Sensing Provides Insights Into the Structure of Short‐Period Ocean‐Generated Seismic Wavefield
Authors: Glubokovskikh Stanislav , Pevzner Roman , Sidenko Evgeny , Tertyshnikov Konstantin , Gurevich Boris , Shatalin Sergey , Slunyaev Alexey , Pelinovsky Efim 
Published: October 2021

AbstractOcean‐generated seismic waves are omnipresent in passive seismic records around the world and present both a challenge for earthquake observations and an input signal for interferometric methods for characterization of the Earth's interior. Understanding of these waves requires the knowledge of the depth dependence of the oceanic noise at the transition into the continent. To this end, we examine 80 days of continuous acquisition with distributed acoustic sensor (DAS) system deployed in two deep boreholes near the south‐eastern coast of Australia. The iDASv3™ system deployed in a deep borehole at the CO2CRC Otway Project site provides sufficiently high sensitivity and low instrumentation noise for frequencies from 100 mHz to 20 Hz. Analysis of the seismograms and correlation with wave climate allows decomposing the DAS response into microseisms generated by swell from remote storms (0.15 Hz) and local winds (between 0.2 and 2 Hz), and strong body wave energy from large surf breaks at the coast (from 2 to 20 Hz). The depth dependence of the microseisms provides useful insights into the energy partition between the Rayleigh wave modes and may augment conventional kinematic analysis of the sparse surface seismological arrays. Overall, ocean‐generated signals at each channel along the borehole are strongly related to the wave climate, so that—with sufficient amount of training data—the passive seismic records on several downhole DAS sensors has a potential for high‐precision monitoring of formations surrounding the borehole as well as remote storms in the ocean.
Numerical Analysis of the Impact of Complex Urban Environment on a Snowfall Event in Beijing
Authors: Guo Liangchen , Fu Danhong , Xiao Hui , Zhang Yanqing , Miao Shiguang 
Published: October 2021

AbstractThe impacts of anthropogenic heat emissions, urban land use, and aerosols on a snowfall event in Beijing were investigated by using the Weather Research and Forecasting model. The results show that urban land use and anthropogenic heat emissions can reduce the accumulation of snowfall by 17%–22% within the fifth ring road, which depends on the aerosol number concentration and size. The increase in aerosols (same land use and anthropogenic heat emissions) can increase the accumulated snowfall within fifth ring road, especially for accumulated and coarse mode. Urban land use, anthropogenic heat emissions, and aerosols have different effect on snowfall, which depend mainly on relatively humidity. Urban land use and anthropogenic heat emissions lead to the formation of an “urban heat and dry island,” which is not favorable to snowfall processes during the initial snowfall processes and leads to a decrease in ice crystals and snow by 47% averaged. At this time, the increase in aerosol number concentrations has less impact (increase by 5% averaged) on snowfall because of higher supersaturation required for activation. With the development of snowfall processes, the feedback of cloud microphysics decrease temperature and increase relative humidity, which is favorable to snowfall process and increase snowfall slightly by 5% averaged. Meanwhile, the critical radius of aerosols that can be activated decrease, smaller particle aerosols are activated to form supercooled cloud water and further to form ice crystals and snow, which leads to an increase in accumulated snowfall by 11% averaged.
Concept and application of circulating proteasomes
Authors: Choi Won Hoon , Kim Sumin , Park Seoyoung , Lee Min Jae 
Published: October 2021

AbstractProteostasis is primarily a function of protein synthesis and degradation. Although the components and processes involved in intracellular proteostasis have been studied extensively, it is apparent that extracellular proteostasis is equitably crucial for the viability of organisms. The 26S proteasome, a unique ATP-dependent proteolytic complex in eukaryotic cells, contributes to the majority of intracellular proteolysis. Accumulating evidence suggests the presence of intact 20S proteasomes in the circulatory system (c-proteasomes), and similar to other plasma proteins, the levels of these c-proteasomes may vary, potentially reflecting specific pathophysiological conditions. Under normal conditions, the concentration of c-proteasomes has been reported to be in the range of ~0.2–2 μg/mL, which is ~2–4-fold lower than that of functional plasma proteins but markedly higher than that of signaling proteins. The characterization of c-proteasomes, such as their origin, structure, role, and clearance, has been delayed mainly due to technical limitations. In this review, we summarize the current perspectives pertaining to c-proteasomes, focusing on the methodology, including our experimental understanding. We believe that once the pathological relevance of c-proteasomes is revealed, these unique components may be utilized in the diagnosis and prognosis of diverse human diseases.
Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation
Authors: Fan Xiaoqing , Fan Junqi , Yang Haoran , Zhao Chenggang , Niu Wanxiang , Fang Zhiyou , Chen Xueran 
Published: October 2021

AbstractGlioblastoma (GBM) is the most common and deadly of the primary intracranial tumors and is comprised of subsets that show plasticity and marked heterogeneity, contributing to the lack of success in genomic profiling to guide development of precision medicine for these tumors. In this study, a mutation in isocitrate dehydrogenase 1 was found to suppress the transforming growth factor-beta signaling pathway and E2F4 interacted with Smad3 to inhibit expression of mesenchymal markers. However, palmitoylation of Smad3 mediated by palmitoyltransferase ZDHHC19 promoted activation of the transforming growth factor-beta signaling pathway, and its interaction with EP300 promoted expression of mesenchymal markers in the mesenchymal subtype of GBM. Smad3 and hypoxia-inducible factor 1-alpha may be important molecular targets for treatment of glioma because they appear to coordinate the basic aspects of cancer stem cell biology.
A stem cell marker KLF5 regulates CCAT1 via three-dimensional genome structure in colorectal cancer cells
Authors: Takeda Takashi , Yokoyama Yuhki , Takahashi Hidekazu , Okuzaki Daisuke , Asai Kaho , Itakura Hiroaki , Miyoshi Norikatsu , Kobayashi Shogo , Uemura Mamoru , Fujita Toshitsugu , Ueno Hiroo , Mori Masaki , Doki Yuichiro , Fujii Hodaka , Eguchi Hidetoshi , Yamamoto Hirofumi 
Published: October 2021

Abstract
Background
KLF5 plays a crucial role in stem cells of colorectum in cooperation with Lgr5 gene. In this study, we aimed to explicate a regulatory mechanism of the KLF5 gene product from a view of three-dimensional genome structure in colorectal cancer (CRC).

Methods
In vitro engineered DNA-binding molecule-mediated chromatin immunoprecipitation (enChIP)-seq method was used to identify the regions that bind to the KLF5 promoter.

Results
We revealed that the KLF5 promoter region interacted with the KLF5 enhancer region as well as the transcription start site (TSS) region of the Colon Cancer Associated Transcript 1 (CCAT1) gene. Notably, the heterodeletion mutants of KLF5 enhancer impaired the cancer stem-like properties of CRC cells. The KLF5 protein participated in the core-regulatory circuitry together with co-factors (BRD4, MED1, and RAD21), which constructs the three-dimensional genome structures consisting of KLF5 promoter, enhancer and CCAT1 TSS region. In vitro analysis indicated that KLF5 regulated CCAT1 expression and we found that CCAT1 expression was highly correlated with KLF5 expression in CRC clinical samples.

Conclusions
Our data propose the mechanistic insight that the KLF5 protein constructs the core-regulatory circuitry with co-factors in the three-dimensional genome structure and coordinately regulates KLF5 and CCAT1 expression in CRC.