bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heart failure with preserved ejection fraction – new elements of evidence in the field of pathophysiology and new treatment options
Authors: Kanazirev Branimir 
Published: July 2021

Consistent with the understanding of the comorbidity-inﬂ ammation relationship, concomitant diseases and especially metabolic comorbidities are thought to stimulate the development and severity of heart failure with preserved ejection fraction through a cascade of mechanisms supporting systemic tissue inﬂ ammation leading to myocardial ﬁ brosis. Recently, new experimental and clinical evidence has emerged that enhances validity and veriﬁ es the inﬂ ammatory-proﬁ brotic paradigm. This evidence consists of: (1) myocardial inﬁ ltration with immunocompetent cells not only due to metabolic load caused by obesity but also due to arterial hypertension-induced haemodynamic loading of extracellular matrix components (such as basal laminatin interacting with basal laminate); (2) expression in cardiomyocytes of inducible nitric oxide synthetase under the inﬂ uence of circulating proinﬂ ammatory cytokines, which leads to accumulation of degraded proteins in the myocardium due to an unfolded protein response; (3) deﬁ ning phenogroups of patients with heart failure with preserved ejection fraction with a distinct inﬂ ammatory and proﬁ brotic component by machining algorithms; (4) direct association. in mediation analysis between comorbidities, inﬂ ammatory biomarkers and impaired myocardial structure and function with endothelial expression of adhesion molecules already accumulated in early preclinical heart failure with preserved ejection fraction (CH stage A, B). This new evidence paves the way for future treatment of heart failure with a conserved ejection fraction with biologics directed against 1) inﬂ ammatory cytokines, 2) stimulating the development of a complete protein response and non-accumulation of protein in the chiocardia by phosphodiesterase inhibitors 1) the rigidity of titin by natriuretic peptide – the particular guanylyl cyclase – PDE9 (phosphodiesterase 9) and 4) molecular and cellular regulatory mechanisms that control myocardial ﬁ brosis.
Single-Cell Analysis Reveals the Heterogeneity of Monocyte-Derived and Peripheral Type-2 Conventional Dendritic Cells
Authors: Gao Yuehan , Li He , Li Zhaohuai , Xie Lihui , Liu Xiuxing , Huang Zhaohao , Chen Binyao , Lin Xianchai , Wang Xianggui , Zheng Yingfeng , Su Wenru 
Published: July 2021

Abstract
Dendritic cells (DCs) are critical for pathogen recognition and Ag processing/presentation. Human monocyte-derived DCs (moDCs) have been extensively used in experimental studies and DC-based immunotherapy approaches. However, the extent of human moDC and peripheral DCs heterogeneity and their interrelationship remain elusive. In this study, we performed single-cell RNA sequencing of human moDCs and blood DCs. We identified seven subtypes within moDCs: five corresponded to type 2 conventional DCs (cDC2s), and the other two were CLEC10A+CD127+ cells with no resemblance to any peripheral DC subpopulations characterized to date. Moreover, we defined five similar subtypes in human cDC2s, revealed the potential differentiation trajectory among them, and unveiled the transcriptomic differences between moDCs and cDC2s. We further studied the transcriptomic changes of each moDC subtype during maturation, demonstrating SLAMF7 and IL15RA as maturation markers and CLEC10A and SIGLEC10 as markers for immature DCs. These findings will enable more accurate functional/developmental analyses of human cDC2s and moDCs.
Epidemiology of Injuries in National Collegiate Athletic Association Men's Track and Field: 2014–2015 Through 2018–2019
Authors: Boltz Adrian J. , Roby Patricia R. , Robison Hannah J. , Morris Sarah N. , Collins Christy L. , Chandran Avinash 
Published: July 2021

Context
College athletes have been competing in championship track and field events since 1921; the numbers of competing teams and participating athletes have expanded considerably.

Background
Monitoring injuries of men's track and field athletes using surveillance systems is critical in identifying emerging injury-related patterns.

Methods
Exposure and injury data collected in the National Collegiate Athletic Association Injury Surveillance Program during the 2014–2015 through 2018–2019 academic years were analyzed. Injury counts, rates, and proportions were used to describe injury characteristics; injury rate ratios were used to examine differential injury rates.

Results
Overall, men's track and field athletes were injured at a rate of 2.37 per 1000 athlete-exposures; injuries occurred at a higher rate during competition compared with practice. Most injuries were to the thigh (26.2%), lower leg (17.3%), or knee (10.7%) and were caused by noncontact (37.2%) or overuse (31.5%) mechanisms. The most reported injury was hamstring tear (14.9%).

Summary
The etiologies of thigh and lower-leg injuries warrant further attention in this population. Future researchers should also separately examine injury incidence during indoor and outdoor track and field seasons.
Epidemiology of Injuries in National Collegiate Athletic Association Women's Tennis: 2014–2015 Through 2018–2019
Authors: Robison Hannah J. , Boltz Adrian J. , Morris Sarah N. , Collins Christy L. , Chandran Avinash 
Published: July 2021

Context
The National Collegiate Athletic Association (NCAA) has sponsored women's tennis programs since 1966. Women's tennis has risen in global prominence and popularity within the NCAA.

Background
Continued surveillance of athletic injuries in the NCAA is critical for identifying emerging injury trends and assessing injury prevention strategies.

Methods
Exposure and injury data collected in the NCAA Injury Surveillance Program from 2014–2015 through 2018–2019 were analyzed. Injury counts, rates, and proportions were used to describe injury characteristics, and injury rate ratios were used to examine differential injury rates.

Results
The overall injury rate was 4.16 per 1000 athlete exposures. Injury to the shoulder, foot, and trunk were the most prevalent throughout the study period. Approximately 30% of all injury diagnoses were related to inflammatory conditions. Also, 32.1% of all injuries were time-loss injuries, and 45.0% of all injuries were non–time-loss injuries.

Conclusions
The findings of this study differed slightly from those of previous investigations, most notably with regard to injury rate by season segment and commonly injured body parts. Future surveillance efforts should attempt to capture the nuances of tennis competitions.
Epidemiology of Injuries in National Collegiate Athletic Association Women's Ice Hockey: 2014–2015 Through 2018–2019
Authors: Chandran Avinash , Nedimyer Aliza K. , Boltz Adrian J. , Robison Hannah J. , Collins Christy L. , Morris Sarah N. 
Published: July 2021

Context
The National Collegiate Athletic Association (NCAA) has sponsored women's ice hockey championships since 2001, and sponsorship has grown over time.

Background
Routine examinations of injuries sustained by athletes are important for identifying and understanding patterns that can be used to inform sport safety practices.

Methods
Exposure and injury data collected in the NCAA Injury Surveillance Program from 2014–2015 through 2018–2019 were analyzed. Injury counts, rates, and proportions were used to describe injury characteristics, and injury rate ratios were used to examine differential injury rates.

Results
The overall injury rate was 5.89 per 1000 athlete-exposures; preseason injury incidence rose sharply during 2016–2017 through 2018–2019. Head/face injuries (15.2%), knee injuries (13.2%), and shoulder injuries (12.9%) were the most commonly injured body parts, and injuries were most often classified as contusions (18.9%), strains (18.7%), and sprains (15.5%). Concussion (11.9%) was the most commonly reported specific injury, and concussion rates notably increased during 2017–2018 through 2018–2019.

Summary
Study findings were generally consistent with the existing epidemiological evidence. Injury incidence in preseason and the etiology of strains warrant further attention in this population.
Epidemiology of Injuries in National Collegiate Athletic Association Men's Swimming and Diving: 2014–2015 Through 2018–2019
Authors: Boltz Adrian J. , Robison Hannah J. , Morris Sarah N. , D'Alonzo Bernadette A. , Collins Christy L. , Chandran Avinash 
Published: July 2021

Context
The National Collegiate Athletic Association (NCAA) has sponsored men's swimming and diving since 1937.

Background
Routine examinations of men's swimming and diving injuries are important for identifying emerging injury-related patterns.

Methods
Exposure and injury data collected in the NCAA Injury Surveillance Program during the 2014–2015 through 2018–2019 academic years were analyzed. Injury counts, rates, and proportions were used to describe injury characteristics, and injury rate ratios were used to examine differences in injury rates.

Results
The overall injury rate was 1.56 per 1000 athlete-exposures (AEs) for swimmers and 1.52 per 1000 AEs for divers. Shoulder (27.0%) injuries accounted for the largest proportion of all swimming injuries, and most injuries were attributed to overuse mechanisms (42.6%). Shoulder (23.3%) and trunk (23.3%) injuries accounted for the largest proportion of all diving injuries, and most injuries resulted from surface contact (32.6%).

Conclusions
Findings were consistent with existing literature on swimming and diving. The need for continued surveillance, coupled with more robust participation by swimming and diving programs was also highlighted.
Emotional Intelligence and Quality of Nursing Care
Authors: Khademi Elmira , Abdi Mohammad , Saeidi Mohammad , Piri Shahram , Mohammadian Robab 
Published: July 2021

Background:
Emotional Intelligence (EI) is necessary for personal and professional success. This study aimed to determine the relationship between EI and quality of nursing care from the viewpoint of nurses and patients.

Materials and Methods:
This descriptive correlational study was conducted using convenience sampling to select the patients (n = 300) and census sampling to select the nurses (n = 100) at Amir Alam Hospital in Tabriz, Iran, in 2018. The data collection tools were the Quality Patient Care Scale (QUALPAC) and EI test by Bradberry-Greaves. Data analysis was performed in SPSS Version 20, using t-test, ANOVA, Chi-square, Pearson's correlation test, and multivariate analysis.

Results:
The mean (SD) score of EI was 91.17 (12.33) in nurses, and the mean (SD) score of nursing care quality was 184.01 (37.41) and 202.22 (22.30) from the viewpoint of patients and nurses, respectively. There was no significant difference between the two viewpoints (p = 0.652). However, there was a significant correlation between the nurses' EI and quality of nursing care (r = 1.00, p < 0.001). The educational level was the strongest predictor of increase in nursing care quality from the patients' viewpoint, according to the multivariate analysis (β = −0.27, p < 0.001).

Conclusions:
EI positively affects the quality of nursing care and its dimensions. Therefore, it is recommended that nursing policymakers consider educational programs to strengthen the nurses' EI and enhance the quality of nursing care. Patients, similar to nurses, can be proper indicators of the quality of nursing care; accordingly, simultaneous use of these indicators is suggested.
Portal Hypertension as a Complication of Cystic Echinococcosis: A 20-Year Cohort Analysis
Authors: Collado Aliaga Javier , Romero-Alegría Ángela , Alonso-Sardón Montserrat , Prieto-Vicente Vanessa , López-Bernus Amparo , Velasco-Tirado Virginia , Sendra de la Ossa Celia , Pardo-Lledias Javier , Belhassen-García Moncef 
Published: July 2021

ABSTRACT.
Cystic echinococcosis (CE) is a parasitic disease caused by the larval forms of species of the tapeworm Echinococcus. The most common location is the liver. To assess the frequency and clinical characteristics of portal hypertension (PH) and the risk factors for PH development, we performed a retrospective observational study of inpatients diagnosed with hepatic CE and PH from January 1998 to December 2018, at Complejo Asistencial Universitario de Salamanca, Spain. Of 362 patients analyzed with hepatic CE, 15 inpatients (4.1%) had a portal vein diameter ≥ 14 mm, and the mean diameter of the portal vein was 16.9 (standard deviation [SD] ±2.1) mm. Twelve patients were men. The mean age was 59.5 years (SD ± 17.8 years). Four patients had ascites (26.6%), four had collateral circulation (26.6%), 14 had hepatosplenomegaly (93.3%), five had esophageal varices (33.3%), four had hematemesis, and three had jaundice. Other causes of PH included hepatitis B virus (1 patient) and hepatitis C virus (1 patient) infections and alcohol abuse (1 patient). The host variables associated with PH development were male sex (odds ratio, 4.6; 95% confidence interval, 1.1–20.9; P = 0.030) and larger cyst size (10.8 ± 6.3 versus 7.6 ± 4.1; P = 0.004). Hepatic CE is an infrequent cause of PH that usually occurs without indications of liver failure. Larger cyst size and male sex were the main risk factors associated with this complication. Mortality was higher for patients with hepatic CE with PH than for patients with hepatic CE without PH.
SOCIAL STUDIES TEACHER CANDIDATES’ PERCEPTION OF URBAN ENVIRONMENT: THE EXAMPLE OF AFYONKARAHISAR, TURKEY
Authors: Utkugün Ceren 
Published: July 2021

<p>This research was conducted to determine social studies teacher candidates’ perceptions of the urban environment of Afyonkarahisar. The study group of the research, which was designed according to the basic qualitative research approach, was 100 teacher candidates generated from a purposeful sampling strategy among the 1st and 4th grade teacher candidates studying at the Department of Social Studies Education at a state university at the beginning of the spring semester of the 2019-2020 academic year. Four questions were employed in the questionnaire consisting of open-ended questions such as “What features do you look for in the city you want to live in?”, “How would you describe Afyonkarahisar?”, “What are the first 5 words that come to your mind when you say Afyonkarahisar?”and “What are the positive and negative aspects of Afyonkarahisar?”. In the last chapter, the teacher candidates were asked to draw a mental image they visualized when Afyonkarahisar was mentioned. The obtained data were analyzed using the content analysis method, presented in the form of content tables, expressed in frequencies, and supported with direct quotations from the teacher candidates’ opinions. According to the findings obtained from the research result; the prominent concepts in the minds and drawings of the teacher candidates have been urban, historical, and gastronomic factors. In Afyonkarahisar descriptions of the teacher candidates, there were negative qualifications such as underdeveloped, small, dirty, and boring and positive qualifications such as quiet/calm, livable, at an important junction point in terms of transportation to other cities, affordable and ideal for students.</p><p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0771/a.php" alt="Hit counter" /></p>
KONSEPTUALISASI INTEGRASI PSIKOLOGI DAN ISLAM (PSIKOLOGI ISLAM) DALAM PEMBELAJARAN DI MADRASAH IBTIDAIYAH
Authors: Tri Wibowo  
Published: July 2021

Tulisan ini bertujuan untuk menguraikan dan mendeskripsikan proses konseptualisasi integrasi Psikologi dan Islam (Psikologi Islam) yang dapat diterapkan dalam pembelajaran di Madrasah Ibtidaiyah. Berawal dari latar belakang dikotomisasi ilmu-ilmu agama dengan umum oleh Barat dengan cara mendirikan pusat pendidikan keagamaan pada tempat yang khusus. Dari sinilah muncul generasi-generasi sekuler yang tidak menguasai ilmu agama atau sebaliknya. Melihat fenomena tersebut, tanggapan dari umat Islam pun beragam. Ada yang menanggapi sebagai sebuah momentum kebangkitan umat Islam di segenap bidang ataupun sebaliknya yang bersifat apatis-dogmatik. Wujud nyata dari semangat kebangkitan umat Islam tercermin dari upaya melahirkan ilmu-ilmu yang Islami, baik melalui Islamisasi ilmu pengetahuan maupun saintifikasi Islam seperti dalam bidang Psikologi Islam. Psikologi Islam dapat diterapkan dalam kegiatan pembelajaran di Madrasah Ibtidaiyah dalam rangka mengoptimalkan segenap potensi yang dimiliki peserta didik yang sedang dalam tahap pertumbuhan dan perkembangan. Metode penelitian yang digunakan yaitu metode penelitian kualitatif jenis riset studi kepustakaan. Teknik pengumpulan data berupa dokumentasi serta analisis data menggunakan teknik analisis konten (content analysis). Hasil penelitian menunjukkan bahwa konseptualisasi integrasi Psikologi dan Islam (Psikologi Islam) dalam pembelajaran di Madrasah Ibtidaiyah dilakukan dengan cara mengintegrasikan konsep Psikologi Islam dengan perencanaan pembelajaran, pelaksanaan pembelajaran, evaluasi pembelajaran, budaya madrasah dan pembiasaan secara terstruktur dan terjadwal kepada peserta didik.
INFLUENCE OF ANAMBRA BROADCASTING SERVICE SLOGAN “DOBE ANAMBRA OCHA” ON AWKA RESIDENTS’ ATTITUDE TOWARDS ENVIRONMENTAL SANITATION
Authors: Francis Nnaemeka Obidike , Chidimma Nlekuwa Gloria 
Published: July 2021

This study entitled Influence of Anambra Broadcasting Service Slogan “Dobe Anambra Ocha” on Awka Residents’ Attitude towards Environmental Sanitation investigatedwhether residents of Awka Metropolishas answered the clarion call contained in the slogan meant to sensitise them to keep their environment clean at all times. Specific objectives of the study among others are to: assess respondents’ frequency of exposure to ABS slogan “Dobe Anambra Ocha;” ascertain whether the ABS slogan “Dobe Anambra Ocha” is effective in sensitizing the residents about environmental sanitation; find out the respondents’ attitude towards the ABS slogan “Dobe Anambra Ocha;” determine whether the ABS slogan “Dobe Anambra Ocha” has helped residents in maintaining good environmental sanitation. The study was anchored on the Theory of Planned Behaviour (TPB). The survey research design was used in carrying out the study. A sample size of 399 was selected from the population of Awka Metropolis using the Taro Yamani’s sample size determination formula. The questionnaire was the instrument used in collecting data for the study. Data generated from the study were presented in statistical table with frequency and simple percentage used in analyzing the data. Results of the analysis showed among others that: 74.9 percent of the respondents had very good exposure to the ABS slogan “Dobe Anambra Ocha”, 73.6 percent attested to the effectiveness of the slogan in sensitizing the residents to keep their environment clean at all times, the respondents had a very positive attitude towards the ABS slogan “Dobe Anambra Ocha”. The study recommended among others that: Credible information is required to attract the needed response in a radio health campaign, such as with the ABS slogan “Dobe Anambra Ocha.” Messages aired continually and consistently can reach many or more persons and are capable of changing the attitude of the residents to comply with safety measures as required. It means that programming/slogan is of essence in order to reach the intended target audience with the required and relevant message. ABS should intensify the campaign/slogan to ensure that the remaining audiences who still have negative attitude towards “Dobe Anambra Ocha” heed the message to keep their environment clean.
Totally Endoscopic Ventricular Septal Defect Closed: How to do it?
Authors: Tien Do Anh , Minh Le Ngoc , Nguyen Tran Thuy , Phong Nguyen Ba , Linh Luu Phuong , Huyen Luong Thi Nhu , Thanh Le Ngoc 
Published: July 2021

Objectives: To describe the procedure of totally endoscopic closure of ventricular septal defect (VSD) without robotic assistance. Methods: Totally endoscopic VSD closure was performed in 17 patiens (12 childrens and 5adults). The age was 8,5 year olds ( from 3 to 46), and the body weight was 31,2 kg (from 10 to 57). 16 patients were diagnosed with peri-membranous VSD and 1 infundibular VSD, in which 5 patients had right ventricular outflow tract stenosis. We used three 5mm-trocarts and one 12mm-trocart in the right chest. Using pperipheral cannulation for ccardiopulmonary bypass, superior vena caval occlusion, Chitwood aortic clamp, right atriotomy and closing VSD by totally endoscopy without a robotically assisted surgical system. Results: There were no postoperative complications and deaths. cardiopulmonary bypass time and Aortic clamping time were 120 mins and 70 mins respectively. The mean mechanical ventilation time was 1.5 hours. Patients was hospitalized for 5.4 days and could resume normal daily activitive after 1 week. Conclusions: Totally endoscopic closure of ventricular septal defect without robotic assistance is safe and feasible leaving only a small surgical scar with good aesthetics.
ОСНОВНЫЕ ОСОБЕННОСТИ СОВРЕМЕННЫХ БАЗ ДАННЫХ ОБЕСПЕЧИВАЮЩИЕ ПРОМЫШЛЕННЫЕ РЕШЕНИЯ ГЛОБАЛЬНЫХ СЕРВИСОВ
Authors: Саринова Асия Жумабаевна , Третьякова Татьяна Ивановна 
Published: July 2021

Работа посвящена описанию основных особенностей современных баз данных, обеспечивающие промышленные решения глобальных сервисов. В статье был представлен рейтинг баз данных, который определил данное исследование. Произведен анализ баз данных OLAP и OLTP, а также современных базы данных, использующие хранилища данных таких социальных сетей, как Instagram, Facebook. Проведенные исследования доказывают что, промышленные решения на базе Cassandra широко распространены для обеспечения сервисов таких компаний, как Cisco, IBM, Cloudkick, Reddit, Digg, Rackspace, Apple, Twitter и Spotify. В результате исследований выявлены определенные преимущества и недостатки системы управления базами данных Cassandra, которые позволили отличить высокую степень масштабируемости, удовлетворяющая огромными данными и требовательными к производительности сценарии ее использования.
New tools for online teaching and their impact on student learning
Authors: Huguet Carme , Pearse Jill , Esteve Jorge 
Published: July 2021

In the context of the global Covid-19 crisis, a practical introductory Geosciences course was redesigned to aid student learning in a 100% virtual format. New materials were created to i) improve disciplinary language range and concept acquisition; ii) make classes more dynamic; iii) provide tools for self-regulated learning and assessment and iv) maintain student motivation. Usefulness of the new materials was evaluated using a voluntary online survey that was answered by 40% of the students. Additional information was obtained from the university's student evaluation survey. All tools were well-rated, but self-assessment quizzes and class presentations had the highest overall scores. Students commented on their usefulness in terms of knowledge acquisition and self-assessment. Perhaps not surprisingly, self-assessment quizzes were the one tool students felt kept them more motivated. These were closely followed by class presentations and short in-class quizzes. Students found the online access to all lesson materials very useful for self-paced learning. According to a majority of students, the in-class quizzes and student participation using the digital the whiteboard made classes more dynamic. Overall, the new strategies succeeded in improving students' learning and independence, but more work is needed to make classes more dynamic, and especially to improve student motivation. Intrinsic motivation is perhaps the most difficult to improve because in a 100% virtual course, it is difficult to promote student-student interactions and receive visual feedback from the class. In view of the survey results, we introduce bonus activities in order to improve extrinsic motivation.