bluuebunny/crossref_metadata_2025_split huggingface dataset:
LEGISLASI PERLINDUNGAN HUKUM TERHADAP FENOMENA FINANCIAL TECHNOLOGY PEER TO PEER LENDING DI INDONESIA
Authors: Aminuddin Nur Afifah 
Published: August 2021

<p><em>Financial technology is the implementation of the use of technology to improve banking and financial services. The emergence of Fintech-based companies, especially those offering lending and borrowing services or Peer To Peer Lending (P2PL) is currently getting the attention of the public and regulators. P2PL-based fintech services are one of the solutions for limited access to financial services in the country and realizing financial inclusion through synergies with financial institutions and technology companies. With the development of fintech peer to peer lending, illegal fintech problems arise which are detrimental to society, so it is necessary to study the legal protection of the regulations that govern it, and how to resolve disputes against it This research is normative by examining legal issues regarding legal protection for consumers and fintech peer to peer lending services and dispute resolution in the fintech business. The research method used includes a statue approach and a conceptual approach.</em></p><p><strong><em>Keywords : </em></strong><em>Legal Protection, Financial Technology Peer to Peer Lending.</em></p><p> </p><p><em>Financial technology </em>merupakan implementasi dari pemanfaatan teknologi untuk peningkatan layanan jasa perbankan dan keuangan. Kemunculan perusahaan-perusahaan berbasis <em>Fintech </em>terutama yang menawarkan layanan pinjam meminjam uang atau <em>Peer To Peer Lending </em>(P2PL) saat ini semakin mendapatkan perhatian publik dan regulator. Layanan <em>fintech </em>berbasis <em>P2PL </em>menjadi salah satu solusi terbatasnya akses layanan keuangan di tanah air dan mewujudkan iklusi keuangan melalui sinerginya dengan istitusi-institusi keuangan dan perusahaan-perusahaan teknologi. Semakin berkembangnya <em>fintech peer to peer lending </em>timbul permasalahan <em>fintech </em>illegal yang banyak merugikan masyarakat, maka itu perlu dilakukan kajian perlindungan hukum terhadap regulasi yang mengaturnya, serta bagaimana penyelesaian sengketa terhadapnya. Penelitian ini bersifat normatif dengan mengkaji isu hukum tentang perlindungan hukum terhadap konsumen dan layanan <em>fintech peer to peer lending</em> dan penyelesaian sengketa pada bisnis <em>fintech.</em> Metode penelitian yang digunakan meliputi pendekatan undang-undang <em>(statue approach)</em> dan pendekatan konseptual <em>(conceptual approach). </em></p><strong>Kata Kunci : </strong>Perlindungan hukum, <em>financial technology peer to peer lending.</em>
Do health preferences differ among Asian populations? A comparison of EQ-5D-5L Discrete Choice Experiments data from 11 Asian studies
Authors: Yang Zhihao , Purba Fredrick , Shafie Asrul Akmal , Igarashi Ataru , Wong Eliza , Lam Hilton , Minh Hoang Van , Lin Hsiang-Wen , Ahn Jeonghoon , Pattanaphesai Juntana , Jo Min-Woo , Mai Vu Quynh , Busschbach Jan , Luo Nan , Jiang Jie 
Published: August 2021

Abstract
Introduction

For establishing EQ-5D-5L value set, the EuroQol Group developed a standardized EQ-VT protocol. Both time-trade off (TTO) method and discrete choice experiment (DCE) method are used in the EQ-VT protocol. Published studies did not make use of the DCE data for comparison purpose. This study aims to compare the health preferences among 11 Asian studies using the DCE data collected in their EQ-5D-5L valuation studies.

Methods

In the EQ-VT protocol, 196 pairs of EQ-5D-5L health states were valued by a general population sample using DCE method for all 11 studies. DCE data was obtained from the study PI. Three different main-effects models were fitted for each study. Coefficients were first tested between studies. Next, the relative importance of dimensions and levels was calculated and compared.

Results

The number of statistically differed coefficients ranged from 5 to 16, out of 20 main-effects coefficients. For the relative importance, there is not a universal preference pattern that fits all studies, but with some common characteristics e.g. mobility is the most weighted dimension except for Vietnam; the relative importance of levels were approximately 20% for level 2, 30% for level 3, 70% for level 4 across all studies.

Discussion

This study confirmed that health preferences heterogeneity among Asian populations. It is therefore justifiable to announce that national/regional value sets should be used for calculating health utility.
NEWS2 Versus PSI in CAP
Authors: Kumari Neelam , Saifullah Nausheen , Ahmed Naseem , Jafri Saira , Barry Aziz , Jawad Nadia 
Published: August 2021

Abstract
Background: In the UK, National Early Warning Score (NEWS2) has been in frequent use to precisely categorize patients according to severity and as an aid in deciding the level of management. NEWS2 is an excellent tool that does not need any laboratory investigation to mark. With Pneumonia Severity Index (PSI), however, many variables are taken into account i.e. clinical, laboratory and imaging to score the patients into classes of severity. Our aim is to compare NEWS2 with PSI to foresee in-hospital mortality in patients with community acquired pneumonia (CAP).Methods: A cross-sectional analytical study was conducted on a sample of 116 Pakistanis presenting with CAP. We performed statistical analyses on SPSS version 22.0 and observed frequencies of various categorized variables. ROC curve for estimating AUC and sensitivity analyses were performed to evaluate predictive validity of each severity score in relation to in-hospital outcome.Results: There were 45 (38.8%) mortalities during the hospital stay. Sensitivity of NEWS2 in terms of mortality prediction was 97.8% but specificity was only 15.5% whereas PSI showed worse sensitivity (68.9%) but better specificity (50.7%).Conclusion: NEWS2 is much more sensitive than specific for prediction of mortality among CAP patients as compared to PSI.
LOGO, a contextualized pre-trained language model of human genome flexibly adapts to various downstream tasks by fine-tuning
Authors: Yang Meng , Huang Haiping , Huang Lichao , Zhang Nan , Wu Jihong , Yang Huanming , Mu Feng 
Published: August 2021

Abstract
Interpretation of non-coding genome remains an unsolved challenge in human genetics due to impracticality of exhaustively annotate biochemically active elements in all conditions. Deep learning based computational approaches emerge recently to help interpretating non-coding regions. Here we present LOGO (Language of Genome), a self-attention based contextualized pre-trained language model that applies self-supervision techniques to learn bidirectional representations of unlabeled human reference genome and extend to a series of downstream tasks via fine-tuning. We also explore a novel knowledge embedded version of LOGO to incorporate prior human annotations. Experiments show that LOGO achieves 15% absolute improvement for promoter identification and up to 4.5% absolute improvement for enhancer-promoter interaction prediction. LOGO exhibits state-of-the-art predictive power on chromatin features with only 3% parameterization against fully supervised convolutional neural network, DeepSEA. Fine-tuned LOGO also shows outstanding performance in prioritizing non-coding variants associated with human diseases. In addition, we apply LOGO to interpret type 2 diabetes (T2D) GWAS signals and infer underlying regulatory mechanisms. We make a conceptual analogy between natural language and human genome and demonstrate LOGO is an accurate, fast, scalable, and robust framework with powerful adaptability to various tasks without substantial task-specific architecture modifications.
Efficacy of intravenous flurbiprofen axetil with epidural analgesia for post-cesarean section analgesia: a multi-center, prospective, randomized, blinded trial
Authors: Wang Ling-Yu , Hu Zu-Rong , Zhang Chun-Yuan , Dai Zai-Shen , Han Bao-Yi , Zeng Wei , Hu Hong-Tao , Song Xing-Rong , She Ying-Jun 
Published: August 2021

Abstract
BackgroundEpidural analgesia provided satisfactory analgesic effects of incision pain after cesarean section. However, uterine contraction pain is also a common complication that cannot be relieved despite adequate levels of sensory blockade by epidural analgesia. This study evaluates the effect of flurbiprofen axetil with patient-controlled epidural analgesia on incision pain and uterine contraction pain after cesarean section.MethodsA multi-center, prospective, randomized, blinded trial was performed. 1000 obstetric patients scheduled for cesarean delivery were randomized to receive epidural analgesia with intravenous flurbiprofen axetil (group EF) or placebo (group E) postoperatively. The primary outcomes were incision pain and uterine contraction pain score 48 hours after a cesarean section. Secondary outcomes were the PCEA attempts, the incidence of complication, satisfaction scores, and return of gastrointestinal (GI) function.ResultsBaseline characteristics were similar between groups. The VAS of uterine contraction pain was significantly lower in group EF than in group E from 12 hours to 48 hours after cesarean delivery (P < 0.01). The VAS of incision pain at rest and on movement was lower in group EF than in group E from 12 hours to 48 hours after cesarean delivery. While sitting or walking, the VAS of incision pain was lower in group EF compared with that in group E. GI function recovered faster in group EF than that in group E (15 ± 6 vs. 25 ± 12, 95%CI 5.7 to 8.7, P < 0.01). The satisfaction scores are higher in group EF than that in group E (3.2 ± 0.5 vs. 2.9 ± 0.5, 95%CI -0.36 to -0.11, P < 0.01).ConclusionCombination flurbiprofen axetil with PCEA provides more effective analgesia for uterine contraction pain and incision pain after cesarean section, with a higher quality of recovery and better satisfaction scores.Trials RegistrationThis study was approved by the Institutional Review Board of Guangzhou Women and Children’s Medical Center (IRB2017062201) and written informed consent was obtained from his or her parents or legal guardians for each pediatric patient in the trial. The trial was registered before patient enrollment at chictr.org.cn (ChiCTR-IOR-17011956, Principal investigator: Ying-Jun She, Date of registration: 2017.07.12). Written informed consent was obtained from patients in the study.
A dynamic framework for updating approximations with increasing or decreasing objects in multi-granulation rough sets
Authors: Wang Hong , Guan Tao 
Published: August 2021

Abstract
The data we need to deal with is getting bigger and bigger in recent years, and the same happens to multi-granulation rough set, so updated schemes have been proposed with the variation of attributes or attribute values in multi-granulation rough sets, this paper puts forward a dynamic mechanism to update the approximations of multi-granulation rough sets when adding or deleting objects. Firstly, the relationships between the original approximations and updated approximations are explored when adding or deleting objects in multi-granulation rough sets, and the dynamic processes of updating optimistic and pessimistic multi-granulation rough approximations are proposed. Secondly, two corresponding dynamic algorithms are proposed to update the lower and upper approximations of optimistic and pessimistic multi-granulation rough sets. Finally, a great quantity of experiments had been implemented, and the results indicate that two dynamic algorithms proposed are more effective than the static algorithm.
Comparison of QSOFA and SIRS Scores for the Prediction of Adverse Outcomes of Secondary Peritonitis in a Tertiary Teaching Hospital in Uganda: a Prospective Cohort Study
Authors: Nkonge Emmanuel , Kituuka Olivia , Ocen William 
Published: August 2021

Abstract
Background: SIRS and qSOFA are two ancillary scoring tools that have been used globally, inside and outside of ICU to predict adverse outcomes of infections such as secondary peritonitis. Mulago hospital uses SIRS outside the ICU to identify patients with secondary peritonitis, who are at risk of adverse outcomes. However it’s associated with delays in decision making given its partial reliance on laboratory parameters. In response to the practical limitations of SIRS, the sepsis-3 task force recommends qSOFA as a better tool, however its performance in patients with secondary peritonitis in comparison to that of SIRS has not been evaluated in Mulago hospital, Uganda.Objective: To compare the performance of qSOFA and SIRS scores in predicting adverse outcomes of secondary peritonitis in Mulago hospital, Uganda.Methods: This was a prospective cohort study of patients with clinically confirmed secondary peritonitis, from March 2018 to January 2019 at the A&E, Mulago hospital. QSOFA and SIRS scores were generated for each of the patient, with a score of ≥ 2 recorded as high risk, while a score of ≤ 2 recorded as low risk for the adverse outcome respectively. After surgery, patients were followed up until discharge or death. In-hospital mortality and prolonged hospital stay were the primary and secondary adverse outcomes, respectively. Sensitivity, specificity, PPV, NPV and accuracy at 95% confidence interval were calculated for each of the scores using STATA v.13Results: A total of 153 patients were enrolled. Of these, 151(M: F, 2.4:1) completed follow up and were analysed, 2 were excluded. Mortality rate was 11.9%. Fourty (26.5%) patients had a prolonged hospital stay. QSOFA predicted in-hospital mortality with AUROC of 0.52 versus 0.62, for SIRS. Similarly, qSOFA predicted prolonged hospital stay with AUROC of 0.54 versus 0.57, for SIRS.Conclusion: SIRS is superior to qSOFA in predicting both mortality and prolonged hospital stay among patients with secondary peritonitis. However, overall, both scores showed a poor discrimination for both adverse outcomes and therefore not ideal tools.
Using Bioinformatics To Mine The Hub Immune-Related Genes in Low-Grade Gliomas Based On TCGA and CGGA Databases
Authors: Xu Chenyang , Li Song , Li Xiaodong , Gao Lei 
Published: August 2021

Abstract
Background

Low grade gliomas(LGG) are the most common malignant tumors in the central nervous system. Tumor cells interact with immune cells and stromal molecules to form glioma immune microenvironment, which plays an important role in tumor progression.
Methods

According to the immune median score of ESTIMATE website, the gene expression and clinical data downloaded from TCGA database was analyzed in subgroups (high and low immune score groups). The DEGs were screened with the change threshold of P < 0.05 and | logfc | ≥ 1, and the volcano map and heat map were drawn by the ggplot2 package. Go and KEGG pathway enrichment analysis were performed by Metascape website. The PPI network of DEGs was constructed by STRING website. The hub genes were screened by using cytohubb plug-in of Cytoscape. CGGA and TCGA websites were utilized to analyze the overall survival of hub genes on LGG, and THPA database was used to further verify those protein expression in LGG and normal tissues.
Results

Subgroup analysis of immune-related score showed that the prognosis of patients was negatively correlated with immune-related score. The ROC curve of 5-year and 3-year survival rate was 0.88 and 0.75 respectively. The immune-related score was substantially correlated with IDH1 mutation status, tumor size and pathological type. The GO term enrichment showed that DEGs were closely related to the activation and regulation of immune related factors, the production and regulation of immune response. KEGG enriched in Staphylococcus aureus infection and phagosome. In addition, CPLX1 and TLR7 were associated with immune cell infiltration in tumor microenvironment.
Conclusions

Subgroups based on immune-related score can guide the prognosis of LGG. And CPLX1 and TLR7 may be the key genes of LGG immunology and potential biological targets for detection, diagnosis and immunology of LGG.
Time to Surgery Does Not Influence Survival Outcome in Patients With Upfront Resected Pancreatic Adenocarcinoma
Authors: Brugel Mathias , Bouché Olivier , Kianmanesh Reza , Teuma Lugdivine , Tashkandi Ahmad , Regimbeau Jean Marc , Pessaux Patrick , Royer Benoit , Rhaiem Rami , Perrenot Cyril , Neuzillet Cindy , Piardi Tullio , Deguelte Sophie 
Published: August 2021

Abstract
BackgroundThis study evaluated the impact of time to surgery (TTS) on overall survival (OS), disease free survival (DFS) and postoperative complication rate in patients with upfront resected pancreatic adenocarcinoma (PA).MethodsWe retrospectively included patients who underwent upfront surgery for PA between January 1, 2004 and December 31, 2014 from four French centers. TTS was defined as the number of days between the date of the first consultation in specialist care and the date of surgery. DFS for a 14-day TTS was the primary endpoint. We also analyzed survival depending on different delay cut-offs (7, 14, 28, 60 and 75 days).ResultsA total of 168 patients were included. 59 patients (35%) underwent an upfront surgery within 14 days. Patients in the higher delay group had significantly more vein resections and endoscopic biliary drainage. Adjusted OS (p = 0.44), DFS (p = 0.99), fistulas (p = 0.41), hemorrhage (p = 0.59) and severe post-operative complications (p = 0.82) were similar in both groups. Other delay cut-offs had no impact on OS or DFS.DiscussionTTS seems to have no impact on OS, DFS and 90-day postoperative morbidity.
Analysis of Immunohistochemical Characteristics and Recurrence After Complete Remission with Fertility Preservation Treatment in Patients with Endometrial Carcinoma and Endometrial a typical Hyperplasia
Authors: Li Liwei , Xiao Zerui , Wang Yiqin , He Yijiao , Wang Zhiqi , Shen Danhua , Wang Jianliu 
Published: August 2021

Abstract
Objective To investigate the relationship between immunohistochemical characteristics and recurrence after complete remission(CR) with fertility preservation treatment in patients with endometrial cancer (EC) and endometrial atypical hyperplasia (AH). Methods The clinical data and immunohistochemical results of 53 patients with EC and 68 patients with AH admitted to Peking University People's Hospital from January 2010 to January 2021 were retrospectively analyzed. Patients were divided into two groups according to whether recurrence after complete remission (CR): Group 1: recurrence after CR; Group 2: no recurrence after CR, for statistical analysis. Results (1)The expression rate of ER in Group 1 was lower than that in Group 2, (P < 0.05). The expression rate of Ki-67 in Group 1 was significantly higher than that in Group 2, (P < 0.01). The expression rates of PR, P16, P53, and PTEN were not significantly different between the two groups (P > 0.05); (2) Combination index ER/ Ki-67 row ROC curve analysis, there was a significant difference (P < 0.01), the best cut-off value was 3.55, sensitivity 0.730, specificity 1.000, Youden index 0.730. The 3-year RFS of high rate patients was 100%, and that of low rate patients was 42.3%, P＜0.01. Conclusions The expression rate of Ki-67 is of great significance in predicting the recurrence of EC after fertility preservation therapy. The best cut-off value of combination index ER/ Ki-67 (3.55) was better than a single immunohistochemical marker in predicting recurrence of EC after fertility preservation treatment.
Identification of Prognostic Biomarkers and Independent Indicators Among PFDN1/2/3/4/5/6 in Liver Hepatocellular Carcinoma
Authors: Dai Yin-Hai , Li Fuping , Kong Wei-Jie , Zhang Xue-Qin , Wang Mao , Ma Hai-Long , Wang Qi 
Published: August 2021

Abstract
Background: Previous studies have proved that the aberrant expressions of PFDNs (Prefoldin) family proteins were correlated with several human cancer. However, the specific functions of PFDNs in liver hepatocellular carcinoma(LIHC) remain unknown. The study aimed to identify the prognostic biomarkers and independent indicators among PFDN1/2/3/4/5/6 in liver hepatocellular carcinoma.Methods: We used these databases including Oncomine, Ualcan, GEPIA2, Human Protein Atlas, The Cancer Genome Atlas, Kaplan-Meier plotter, cBioPortal, STRI-NG and TIMER and the software of Cytoscape in our study.Results: PFDN1/2/3/4/5/6 were highly expressed in LIHC tissues. The mRNA expression levels of PFDN1/2/3/4/5/6 were relevant to tumor grades.PFDN1/3/4/5 expressions significantly changed in different cancer stages. The protein expression levels of PFDNs were higher in LIHC tissue than normal liver tissue. Moreover, High mRNA expressions of PFDN1/2/3/4 were associated with shorter OS of LIHC patients. In multivariate analysis,high expressions of PFDN1/2/4 were independently correlated with poorer OS of LIHC patients. In our findings,55% of patients with LIHC had genetic mutations on PFDNs. Besides, there were significant associations between the expressions of PFDN1/2/3/4/5 and six types of infiltrated immune cells(B cells, CD4+T cells, CD8+T cells, neutrophil, macrophage, and dendritic cells).Conclusions:PFDN1/2/3/4 were potential prognostic markers to suggest poor OS of LIHC patients. In addition, high PFDN1/2/4 expressions were independent prognostic factors in OS for LIHC patients.
Development of The Psychosocial Adaptation Questionnaire Among Breast Cancer Women With Adjuvant Endocrine Therapy in China
Authors: Jiang Haoran , Zhang Xiujie , Dong Yu , Xu Hui , Jin Feng 
Published: August 2021

Abstract
Background
The adjuvant endocrine therapy (AET) of breast cancer often impacts women on physiological, psychological, and social facets, which requires them to adjust to achieve psycho-social adaptation (PSA). As a standardized evaluation tool was lacking, we developed a PSA questionnaire of breast cancer women with AET.
Methods
Item development and extraction based on literature, qualitative interviews (n = 16) and assessment of content validity in phase I. Phase II: 300 participants were used to perform item analysis, internal consistency reliability, and exploratory factor analysis by cross-sectional studies. Phase III: Test–retest, criterion validity, and confirmatory factor analysis of the questionnaire were performed with 96 respondents.
Results
In Phase I, the initial questionnaire was formed. In Phase II, exploratory factor analysis demonstrated 4 factors: emotional dimension (6 items), self-cognitive (5 items), self-image (3 items), and social dimension (2 items), the cumulative contribution of the factors was 65.057%. The Cronbach’s alpha coefficient of the questionnaire was 0.876. The correlation coefficient between the questionnaire and General Self-Efficacy Scale (GSES) was 0.565 (p < 0.01). In Phase III, the 16-item questionnaire and its factorial structure was confirmed.
Conclusions
The 16-item questionnaire has been confirmed by good reliability and validity. In conclusion, it could be a useful tool to assess the PSA among breast cancer women with AET and provide a basis for further research.