bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arabidopsis aldehyde oxidase 3, known to oxidize abscisic aldehyde to abscisic acid, protects leaves from aldehyde toxicity
Authors: Nurbekova Zhadyrassyn , Srivastava Sudhakar , Standing Dominic , Kurmanbayeva Assylay , Bekturova Aizat , Soltabayeva Aigerim , Oshanova Dinara , Turečková Veronica , Strand Miroslav , Biswas Md. Sanaullah , Mano Jun’ichi , Sagi Moshe 
Published: September 2021

SUMMARYThe Arabidopsis thaliana aldehyde oxidase 3 (AAO3) catalyzes the oxidation of abscisic aldehyde (ABal) to abscisic acid (ABA). Besides ABal, plants generate other aldehydes that can be toxic above a certain threshold. AAO3 knockout mutants (aao3) exhibited earlier senescence but equivalent relative water content compared with wild‐type (WT) during normal growth or upon application of UV‐C irradiation. Aldehyde profiling in leaves of 24‐day‐old plants revealed higher accumulation of acrolein, crotonaldehyde, 3Z‐hexenal, hexanal and acetaldehyde in aao3 mutants compared with WT leaves. Similarly, higher levels of acrolein, benzaldehyde, crotonaldehyde, propionaldehyde, trans‐2‐hexenal and acetaldehyde were accumulated in aao3 mutants upon UV‐C irradiation. Aldehydes application to plants hastened profuse senescence symptoms and higher accumulation of aldehydes, such as acrolein, benzaldehyde and 4‐hydroxy‐2‐nonenal, in aao3 mutant leaves as compared with WT. The senescence symptoms included greater decrease in chlorophyll content and increase in transcript expression of the early senescence marker genes, Senescence‐Related‐Gene1, Stay‐Green‐Protein2 as well as NAC‐LIKE, ACTIVATED‐BY AP3/P1. Notably, although aao3 had lower ABA content than WT, members of the ABA‐responding genes SnRKs were expressed at similar levels in aao3 and WT. Moreover, the other ABA‐deficient mutants [aba2 and 9‐cis‐poxycarotenoid dioxygenase3‐2 (nced3‐2), that has functional AAO3] exhibited similar aldehydes accumulation and chlorophyll content like WT under normal growth conditions or UV‐C irradiation. These results indicate that the absence of AAO3 oxidation activity and not the lower ABA and its associated function is responsible for the earlier senescence symptoms in aao3 mutant.
Speculative attacks and investor attention
Authors: Piccoli Pedro 
Published: September 2021

AbstractThis paper presents the first evidence that the investor attention can be used to forecast currency prices in a speculative attack. Investigating the attacks that affected several emerging economies in the second semester of 2018, I document a strong influence of investor attention on the price and risk of the currency under attack, and this influence monotonically rises with the increase of the attacks’ severity. Moreover, this association is absent outside of the attacks or for those emerging currencies that did not experience an attack in the sample period. These findings are robust to several alternative explanations and provide further support for the importance of retail investors to asset pricing.
HDD by Intersection Technique (Case Study): A Novel Approach
Authors: Mazumdar Dipanjan , Singh Akhilesh Kumar , Kishore Raj 
Published: September 2021

Abstract
Horizontal Directional Drilling (HDD) is a trenchless construction technique used extensively in the installation of pipeline carrying hydrocarbons, water, sewage, cables etc., across obstructions where conventional trench and lay method or jacking-boring method cannot be suitably applied. HDD technique also minimises the impact of installation activities in densely populated and ecologically sensitive areas. HDD technique, however, has its inherent shortcomings which render it unsuitable in many real-world scenarios. The torque available at the mud-motor for driving and steering of the drill is fairly reduced for long length crossings. Also, maintaining the directional control of the drill bit becomes increasingly difficult for such long crossings. These shortcomings can be overcome using “Intersect Technique” by utilising electromagnetic steering technology for precise real-time tracking, wherein pilot holes are drilled from both ends using two separate drilling arrangements. On reaching the predefined intersection range, a virtual handshake between the drill bits is achieved. Thereafter, the primary rig continues the bore to the end of the design path to reach at the secondary rig side.
The present case study discusses at length the execution of HDD crossing of 18”- 2523 metre multi-product pipeline alongwith 6” CS conduit for OFC of M/s BPCL across the Thane-Vashi Creek in Mumbai, India. The length of the crossing combined with the presence of numerous pipelines of various operators made the execution of this pipeline crossing by “Intersection Technique” as the most suitable methodology. The pipeline was laid at an average depth of 15 m below the lowest creek bed level in geology which primarily included weathered basalt rock. The pilot hole for the crossing was completed utilising ParaTrack® drilling guidance and tracking system.
Manufacturing of LSAW Pipes Using Hot Rolled Sheets for Sour-Service Application
Authors: Goyal Rajesh Kumar , Gajjar Mahesh , Joshi Ashok , Tamhane Anupkumar 
Published: September 2021

Abstract
The exploration and transportation of fluids from corrosive fields or reserves demand corrosion-resistant pipelines. The pipelines for sour-service application demand higher resistance to H2S corrosion because of higher sulphur content observed in the geographical locations. The pipelines laid in the corrosive and marshy lands demand high wall thickness to allow for wall thinning due to corrosion. The linepipes manufactured using TMCP plates are widely accepted for sour-service applications. The use of cut-to-length sheets from hot rolled coils for the manufacturing of LSAW pipes is economical but having limited acceptance by the pipeline operators.
Welspun took an initiative to develop the linepipes for an onshore sour-service application using API 5L X60MS grade cut-to-length sheets from TMCP hot rolled coils procured from an approved steel mill. The LSAW pipes of 24” OD × 14.27 mm WT were manufactured by the JCO-E press at Welspun Pipes Mill in Anjar-Gujarat-India. The experience of 24”OD × 14.30 mm WT, API 5L X60MO grade pipes manufacturing using TMCP plates procured from another approved steel mill, was used to decide factors such as alloy design, cleanliness, strength, DWTT, hardness, HIC, SSCC, CVN for the selection of cut-to-length sheets. This paper deals with sheet-to-pipe behavioural changes in properties before and after cold mechanical expansion. Wherever possible, the comparison was also made with plate-pipe behavioural changes in properties.
Investigation of Ultrasonic Testing Failure in ERW Line Pipe of API 5L X52M Grade
Authors: Patel R. S. , Sharma Mayank , Chauhan Dhrumil , Makvana Hiral 
Published: September 2021

Abstract
Electric resistance welding (ERW) is conventional manufacturing technology for production of linepipe. ERW is known for its low cost, high efficiency & reliability. Investigation was performed on Electric Resistance Welded (ERW) pipes having Ultrasonic Test (UT) indication observed during in-process inspection. The location of indication was adjacent to weld fusion line. The study was done on pipe size 168 mm (6.6 inch) outside diameter and 6.4 mm wall thickness of API 5L X52M grade to verify the cause of UT failure related to pipe manufacturing process and/or steel making process. The samples were drawn from UT indicated area and analysis is carried out by chemical testing, optical microscopy and scanning electron microscopy with energy dispersive spectroscopy. From systematical research by Why-Why analysis, it is clear that the reason of sub-surface defects on ERW pipe is due to presence of non-metallic inclusions. On the basis of the composition of observed non metallic inclusion, possible sources are identified. The countermeasures for each source cause were verified and successfully implemented the affected one.
What work is required to implement and sustain the National Surgical Quality Improvement Program (NSQIP)? A qualitative study of NSQIP implementation in Alberta, Canada
Authors: Schroeder Dawn , Luig Thea , Beesoon Sanjay , Robert Jill , Campbell-Scherer Denise , Brindle Mary 
Published: September 2021

ObjectivesHospitals introducing the National Surgical Quality Improvement Program (NSQIP) face implementation challenges. To understand the work of embedding NSQIP into routine practice, we explored interactions between contextual factors and the work among implementation teams at the individual, team and organisational level to illuminate how to support and sustain NSQIP implementation.DesignQualitative interpretative study using thematic analysis.SettingFive contextually diverse hospital sites in Alberta, Canada, for in-depth interviewing and four additional hospitals for observation of NSQIP meetings.Participants9 Surgeon and Anaesthesiologist Champions; 6 Surgical Clinical Reviewers; 4 Directors and 1 Surgical Site Manager; 3 Operating Room Managers; 3 Quality Improvement Consultants; 1 Surgeon and 1 Provincial NSQIP Lead.MethodsTo capture context, process and the dynamic interplay between the two, we integrated the Consolidated Framework for Implementation Research (CFIR) and Normalisation Process Theory (NPT) to guide data collection and analysis. 28 individual semi-structured interviews with key informants and observations with field notes of 10 NSQIP meetings were conducted. Data were coded deductively and inductively and analysed thematically.ResultsKey findings informed by CFIR describe the impact of Provincial Collaboratives, leadership support and resources to support NSQIP work. Key findings illuminated by NPT highlight how teams overcame mistrust in NSQIP through relationship building, creating formative spaces to inform collective understandings of NSQIP and inviting feedback from professional groups to cocreate quality improvement solutions. This approach led to increased engagement with NSQIP data and encouraged shifts in conversations within and between nursing and physician groups from problems to solutions based.ConclusionsThe work the teams did to implement and sustain NSQIP highlights the need for time and resources to develop shared understandings of work processes, reorganise themselves to work together and understand how to help others in the surgical community interpret and value using NSQIP to improve care.
Effect of food insecurity on mental health of patients with tuberculosis in Southwest Ethiopia: a prospective cohort study
Authors: Soboka Matiwos , Tesfaye Markos , Adorjan Kristina , Krahl Wolfgang , Tesfaye Elias , Yitayih Yimenu , Strobl Ralf , Grill Eva 
Published: September 2021

ObjectiveThe objective of this study is to investigate the effect of food insecurity on the mental health of patients with tuberculosis (TB) in Ethiopia.DesignA prospective cohort study.SettingHealth centres and hospitals located in Jimma zone, Southwest Ethiopia.ParticipantsPatients with TB who had recently been diagnosed with TB and started directly observed treatment in the selected 26 health institutions from October 2017 to October 2018. A total of 268 patients were followed for 6 months and data were collected at recruitment and two follow-up visits (at 2 and 6 months). Patients with multidrug-resistant TB were not included in the study.Main outcome measuresMental distress was measured by the Self-Reporting Questionnaire-20 while food insecurity was assessed by using the Household Food Insecurity Access Scale.ResultsA total of 268 patients were recruited and there was no lost to follow-up. The prevalence of food insecurity at baseline, first and second follow-up was 49.3%, 45.9% and 39.6%, respectively. Of these, 28.0% of them reported severe food insecurity at baseline which declined to 23.5% at the end of the sixth month. Likewise, the prevalence of mental distress at baseline was 61.2% but declined to 22.0% at the second follow-up. At baseline, 77.3% of patients with mental distress reported severe food insecurity but declined to 46.0% at second follow-up. In the final model, severe food insecurity (OR 4.7, 95% CI 2.4 to 9.4) and being a government employee (adjusted odds ratio (aOR) 0.3, 95% CI 0.1 to 0.9) were associated with mental distress.ConclusionIn this study, food insecurity was associated with mental distress over the course of follow-up. Likewise, there is a high prevalence of food insecurity and mental distress among patients with TB on treatment. Therefore, early assessment and interventions for food insecurity may improve the mental health of patients with TB on treatment.
Lay and healthcare providers’ experiences to inform future of respectful maternal and newborn care in Tanzania and Malawi: an Appreciative Inquiry
Authors: Mdoe Paschal , Mills Tracey A , Chasweka Robert , Nsemwa Livuka , Petross Chisomo , Laisser Rose , Chimwaza Angela , Lavender Tina 
Published: September 2021

ObjectivesDisrespectful care, which remains prevalent in low and middle-income countries (LMICs), acts as a barrier to women accessing skilled birth attendance, compromising care when services are available. Building on what was positive in facilities, we aimed to explore lay and healthcare providers’ experience of respectful care to inform future interventions.SettingFive maternity facilities in Mwanza Tanzania and Lilongwe Malawi.Participants94 participants in Malawi (N=46) and Tanzania (N=48) including 24 women birthing live baby within the previous 12 months; 22 family members and 48 healthcare providers who regularly provided maternity care in the included facilitiesDesignThe study was guided by Appreciative Inquiry (AI). Semistructured, one-to-one interviews were conducted between January and December 2019. Interviews were audio-recorded, translated where necessary, transcribed verbatim, and analysed using the framework approach.ResultsFour main themes describing participants positive experience and their vision of respectful care were identified: (1) empathic healthcare provider–woman interactions including friendly welcome and courteous language, well-timed appropriate care and information sharing, (2) an enabling environment, characterised by improvement of physical environment, the use of screens, curtains and wall partitions for privacy, availability of equipment and provision of incentives to staff, (3) supportive leadership demonstrated by the commitment of the government and facility leaders to provision of respectful care, ensuring availability of guidelines and policies, supportive supervision, reflective discussion and paying staff salaries timely, (4) providers’ attitudes and behaviours characterised by professional values through readiness, compassionate communication and commitment.ConclusionThe positive experiences of service users, families and healthcare providers provided insight into key drivers of respectful care in facilities in Tanzania and Malawi. Interventions targeting improved environment and privacy, healthcare provider communication and developing positive leadership structures in facilities could provide the basis for sustained improvement in respectful and dignified maternal and newborn care in LMICs.
Sick leave and return to work for patients with anxiety and depression: a longitudinal study of trajectories before, during and after work-focused treatment
Authors: Sandin Kenneth , Anyan Frederick , Osnes Kåre , Gunnarsdatter Hole Gjengedal Ragne , Risberg Leversen Jonas Sigurd , Endresen Reme Silje , Hjemdal Odin 
Published: September 2021

ObjectivesSick leave due to anxiety and depression is a heterogeneous process constituting a pressing public health issue. This longitudinal study aimed to identify sick leave trajectories among patients before, during and after work-focused treatment, in all 29.5 months. We then aimed to determine the background and clinical characteristics of these trajectory groups.MethodsBackground and clinical data were collected by patient self-report (N=619) in an observational study in a specialised mental healthcare clinic. Sick leave was recorded from national registry data. A latent growth mixture model identified trajectories. Multinomial logistic regression determined differences in background characteristics while a one-way analysis of variance (ANOVA) identified clinical differences.ResultsWe identified three trajectories: The ‘Resilient’ group (47.7%) had low sick leave throughout the period. The two other groups (‘Recovery’, 31.8% and ‘High risk’, 20.5%) had similar pretreatment trajectories: lower sick leave one year prior which increased to high sick leave at the start of treatment. After treatment, the ‘Recovery’ group made an almost full return to work while the ‘High risk’ group remained at high sick leave. The two groups with high sick leave had more women and higher age compared with the ‘Resilient’ group. All groups had similar clinical scores at the start of treatment, but the ‘High risk’ groups had residual depressive symptoms at the end of treatment. Effect sizes for anxiety and depression were moderate or large for all groups, (Cohen’sd=0.74–1.81), and 87.2% of the total sample were fully working one year after treatment.ConclusionWe found three subgroups with distinctly different trajectories. Female gender and higher age were associated with high sick leave at the start of treatment, while residual depressive symptoms at the end of treatment predicted continued sick leave. The study points to the possibility of improving patient outcomes in the future by stratifying and tailoring treatment to patient characteristics.
Birhan maternal and child health cohort: a study protocol
Authors: Chan Grace J , Hunegnaw Bezawit Mesfin , Van Wickle Kimiko , Mohammed Yahya , Hunegnaw Mesfin , Bekele Chalachew , Goddard Frederick G B , Tadesse Fisseha , Bekele Delayehu 
Published: September 2021

IntroductionReliable estimates on maternal and child morbidity and mortality are essential for health programmes and policies. Data are needed in populations, which have the highest burden of disease but also have the least evidence and research, to design and evaluate health interventions to prevent illnesses and deaths that occur worldwide each year.Methods and analysisThe Birhan Maternal and Child Health cohort is an open prospective pregnancy and birth cohort nested within the Birhan Health and Demographic Surveillance System. An estimated 2500 pregnant women are enrolled each year and followed through pregnancy, birth and the postpartum period. Newborns are followed through 2 years of life to assess growth and development. Baseline medical data, signs and symptoms, laboratory test results, anthropometrics and pregnancy and birth outcomes (stillbirth, preterm birth, low birth weight) are collected from both home and health facility visits. We will calculate the period prevalence and incidence of primary morbidity and mortality outcomes.Ethics and disseminationThe cohort has received ethical approval. Findings will be disseminated at scientific conferences, peer-reviewed journals and to relevant stakeholders including the Ministry of Health.
Virtual reality for relatives of ICU patients to improve psychological sequelae: study protocol for a multicentre, randomised controlled trial
Authors: Vlake Johan H , van Bommel Jasper , Wils Evert-Jan , Korevaar Tim , Hellemons Merel E , Klijn Eva , Schut Anna FC , Labout Joost AM , Van Bavel Marten P , van Mol Margo MC , Gommers Diederik , van Genderen Michel E 
Published: September 2021

IntroductionIntensive care unit (ICU) admission of a relative might lead to psychological distress and complicated grief (post-intensive care syndrome–family; PICS-F). Evidence suggests that increased distress during ICU stay increases risk of PICS-F, resulting in difficulty returning to their normal lives after the ICU experience. Effective interventions to improve PICS-F are currently lacking. In the present trial, we hypothesised that information provision using ICU-specific Virtual Reality for Family members/relatives (ICU-VR-F) may improve understanding of the ICU and subsequently improve psychological well-being and quality of life in relatives of patients admitted to the ICU.Methods and analysisThis multicentre, clustered randomised controlled trial will be conducted from January to December 2021 in the mixed medical-surgical ICUs of four hospitals in Rotterdam, the Netherlands. We aim to include adult relatives of 160 ICU patients with an expected ICU length of stay over 72 hours. Participants will be randomised clustered per patient in a 1:1 ratio to either the intervention or control group. Participants allocated to the intervention group will receive ICU-VR-F, an information video that can be watched in VR, while the control group will receive usual care. Initiation of ICU-VR-F will be during their hospital visit unless participants cannot visit the hospital due to COVID-19 regulations, then VR can be watched digitally at home. The primary objective is to study the effect of ICU-VR-F on psychological well-being and quality of life up to 6 months after the patients’ ICU discharge. The secondary outcome is the degree of understanding of ICU treatment and ICU modalities.Ethics and disseminationThe Medical Ethics Committee of the Erasmus Medical Centre, Rotterdam, the Netherlands, approved the study and local approval was obtained from each participating centre (NL73670.078.20). Our findings will be disseminated by presentation of the results at (inter)national conferences and publication in scientific, peer-reviewed journals.Trial registration numberNetherlands Trial Register (TrialRegister.nl, NL9220).
Protocol for the Stimulating β3-Adrenergic Receptors for Peripheral Artery Disease (STAR-PAD) trial: a double-blinded, randomised, placebo-controlled study evaluating the effects of mirabegron on functional performance in patients with peripheral arterial disease
Authors: Bubb Kristen J , Harmer Jason A , Finemore Meghan , Aitken Sarah Joy , Ali Zara S , Billot Laurent , Chow Clara , Golledge Jonathan , Mister Rebecca , Gray Michael P , Grieve Stuart M , Hamburg Naomi , Keech Anthony C , Patel Sanjay , Puttaswamy Vikram , Figtree Gemma A 
Published: September 2021

IntroductionThere is currently only one approved medication effective at improving walking distance in people with intermittent claudication. Preclinical data suggest that the β3-adrenergic receptor agonist (mirabegron) could be repurposed to treat intermittent claudication associated with peripheral artery disease. The aim of the Stimulating β3-Adrenergic Receptors for Peripheral Artery Disease (STAR-PAD) trial is to test whether mirabegron improves walking distance in people with intermittent claudication.Methods and analysisThe STAR-PAD trial is a Phase II, multicentre, double-blind, randomised, placebo-controlled trial of mirabegron versus placebo on walking distance in patients with PAD. A total of 120 patients aged ≥40 years with stable PAD and intermittent claudication will be randomly assigned (1:1 ratio) to receive either mirabegron (50 mg orally once a day) or matched placebo, for 12 weeks. The primary endpoint is change in peak walking distance as assessed by a graded treadmill test. Secondary endpoints will include: (i) initial claudication distance; (ii) average daily step count and total step count and (iii) functional status and quality of life assessment. Mechanistic substudies will examine potential effects of mirabegron on vascular function, including brachial artery flow-mediate dilatation; MRI assessment of lower limb blood flow, tissue perfusion and arterial stiffness and numbers and angiogenesis potential of endothelial progenitor cells. Given that mirabegron is safe and clinically available for alternative purposes, a positive study is positioned to immediately impact patient care.Ethics and disseminationThe STAR-PAD trial is approved by the Northern Sydney Local Health District Human Research Ethics Committee (HREC/18/HAWKE/50). The study results will be published in peer-reviewed medical or scientific journals and presented at scientific meetings, regardless of the study outcomes.Trial registration numberACTRN12619000423112; Results.