bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mid-Term Outcomes of Cemented Stem and Subtrochanteric Shortening Derotational Osteotomy in Total Hip Arthroplasty for Crowe IV Developmental Dysplasia
Authors: Huang Zhe-Yu , Ling Jing , Zeng Zhi-Min , Di Zheng-Lin , Zhang Jun-Hui , Tao Kun 
Published: August 2021

Abstract
Background Performing total hip arthroplasty (THA) in patients with Crowe IV developmental dysplasia of the hip (DDH) is technically challenging. Subtrochanteric shortening osteotomy is typically required for placing the acetabular component within the anatomic hip center. However, the outcomes of subtrochanteric osteotomy using cemented components are not widely reported. This study aimed to evaluate the outcomes of cemented stem THA with subtrochanteric femoral shortening and transverse derotational osteotomy in patients with Crowe IV DDH.Methods We retrospectively evaluated data of patients with Crowe IV DDH who underwent cemented stem THA with subtrochanteric femoral shortening and transverse derotational osteotomy between 2010 and 2018. Patients who underwent surgery at the hip joint were excluded. Data regarding pre- and postoperative clinical and radiological parameters were collected and reviewed.Results Among 14 patients included (14 hips), the mean age was 60.4 (range, 47–73) years. The mean Harris hip score improved from 40.7 to 87.7. The mean limb length discrepancy reduced from 52 mm to 12.7 mm. No neurologic deficits were noted. The mean osteotomy union time was 10.6 months. Delayed union and postoperative dislocation were observed in one and two patients, respectively. Cement leakage into the osteotomy gap was observed in one patient. No revisions were required. No signs of loosening or migration were observed. Conclusions Cemented stem THA combined with subtrochanteric femoral shortening and transverse derotational osteotomy is safe and effective for the treatment of patients with Crowe IV DDH. The cemented femoral component showed promising mid-term follow up results. However, cement leakage affects bone healing. Osteotomy and cementing should be performed meticulously.Trial Registration: Retrospectively registered
Impact of Management Factors on Seminal Attributes and Frozen Semen Doses Production in Holstein Friesian Crossbred Dairy Bulls
Authors: Mandal Dilip Kumar , Kumar Mahesh , Tyagi Shrikant 
Published: August 2021

Abstract
This study reports on important management factors that have impacts on semen characteristics, sperm production ability and cryo-preservability in dairy bulls. Except volume, bull types (FSD i.e. frozen semen dose producer vs Non-FSD bulls) differentiated most of the semen traits (P < 0.01). Age showed significant impacts on seminal attributes both in FSD and Non-FSD bulls. In FSD bulls semen traits increased significantly even up to 5 years age, in contrast, only 2 years in Non-FSD bulls. Overall semen quality index improved almost linearly with age advancement in FSD bulls (P < 0.01) but not in Non-FSD bulls, which showed very irrational trends. Seasons significantly (P < 0.01) influenced ejaculate characteristics. Overall semen quality, total sperm output and FSD production was the highest during summer and lowest in rainy seasons. Within a bull type (FSD/non-FSD) influence of age and season, and within age group impact of seasons was significant in most of the semen attributes. It was concluded that dependent on season, age of bull significantly influenced qualitative and quantitative attributes of semen; improvement being substantial in FSD bulls, but negligible in non-FSD bulls beyond 2 years age. Seasons of collection significantly influenced semen quality, sperm productivity and FSD production of bulls being highest in summer, followed by winter and least in rainy seasons. The study recommended that for effective FSD production, poor semen producer bulls should be culled as early as 2 years of age and during rainy season stress amelioration measures might mitigate FSD production losses from crossbred bulls.
The effect of low dose γ-irradiation on the optoelectric properties of n-GaN based MSM structure
Authors: Barghamadi Leyla , Alam Shahab Norouzian , Ghafari Bijan , Sedighy Seyed Hassan 
Published: August 2021

Abstract
The room temperature effect of a low dose rate (10-4 rad (Si)/s) 60 Co γ-irradiation on the structural propertiesand dark current of the GaN-based metal-semiconductor-metal (MSM) structure has been studied. In contrast to previous studies, a non-monotonous dependence of the dark current with the γ-irradiation dose is observed. The intensity and linewidth of the photoluminescence (PL) peaks correlate with the changes in electrical characteristics and eventually degrade after prolonged exposure to the γ-radiation. The abnormal behavior of the MSM structure and particularly its I-V and PL characteristics are explained by considering the carrier transfer mechanism in the localized states. These phenomena are associated with the decrease of shallow donors’ density in localized states and the activation of the non-radiative centers as radiation dose increases. These experimental results and the mechanism presented are essential for understanding the interaction of the γ-irradiation with n-GaN and for estimation of reliability of GaN-based (opto)electronics in harsh conditions of γ-radiation (space applications, liquidation of consequences of technogenic catastrophes, etc.).
Network Analysis of Trauma in Patients With Early-Stage Psychosis
Authors: Kheirabad Maryam Karami , Yun Je-Yeon , Nguyen Thong Ba , Rami Fatima Zahra , Piao Yan Hong , Li Ling , Lee Bo Mi , Kim Woo-Sung , Sui Jing , Kim Sung-Wan , Lee Bong Ju , Kim Jung Jin , Yu Je-Chun , Lee Kyu Young , Won Seung-Hee , Lee Seung-Hwan , Kim Seung-Hyun , Kang Shi Hyun , Kim Eui Tae , Chung Young Chul 
Published: August 2021

Abstract
Objectives: Childhood trauma (ChT) is a risk factor for psychosis. Negative lifestyle factors such as rumination, negative schemas, and poor diet and exercise are common in psychosis. The present study aimed to perform a network analysis of interactions between ChT and negative lifestyle in patients and controls.Methods: We used data of patients with early-stage psychosis (n = 500) and healthy controls (n = 202). Networks were constructed using 12 nodes from five scales: the Brief Core Schema Scale (BCSS), Brooding Scale (BS), Dietary Habits Questionnaire, Physical Activity Rating, and Early Trauma Inventory Self Report-Short Form (ETI). Graph metrics were calculated.Results: The nodes with the highest predictability and expected influence in both patients and controls were cognitive (Co) and emotional domains (Em) of the BS and emotional abuse (EMO) of the ETI. The EMO was a mediator in the shortest pathway connecting the ETI and negative lifestyle for both groups. The negative other (NO) and negative self (NS) of the BCSS mediated EMO to other BCSS or BS for patients and controls, respectively.Conclusion: Our findings suggest that rumination and EMO were central symptoms in both groups and that NO and NS played important mediating roles for patients and controls, respectively.Trial Registration: ClinicalTrials.gov identifier: CUH201411002
Mxene-Assisted Organic Electrochemical Transistor Biosensor With Multiple Spiral Interdigitated Electrodes for Sensitive Determination of fPSA/tPSA.
Authors: Zhu Yi-Cheng , Cai Biao , Jiang Quan , Zhang Yuan , Sha Jianjun , Xie Shaowei 
Published: August 2021

Abstract
Background: The ratio of fPSA/tPSA in the “grey zone” of tPSA with the concentration range between 4 ng/ml and 10 ng/ml is significant for diagnosis of prostate cancer, and highly efficiency quantification of the ratio of fPSA/tPSA remain elusive mainly because of their extremely low concentration in patients’ peripheral blood with high biosample complexity.Methods: We presented an interdigitated spiral-based MXene-assisted organic electrochemical transistors (isMOECTs) biosensor for highly sensitive determination of fPSA/tPSA. The combination of MXene and the interdigitated multiple spiral architecture synergistically assisted the amplification of amperometric signal of biosensor with dual functionalizations of anti-tPSA and anti-fPSA.Results: The ultrasensitivity of the biosensor was enhanced by tunable multiple spiral architecture and MXene nanomaterials; and the sensor demonstrated enhanced detection limit of tPSA and fPSA down to 0.01 pg/ml, as well as satisfactory selectivity, reproducibility and reliability, which was comparable to the best previous literatures; Moreover, the isMOECTs displayed area under the curve (AUC) value of 0.8138, confirming the potential applications of isMOECTs in clinics.Conclusions: The merits of isMOECTs biosensor demonstrated the reliability of MXene-assisted organic electrochemical transistor biosensor with multiple interdigitated spiral for ultrasensitive quantification of fPSA/tPSA, suggesting potential current and future point-of-care testing applications.
The Mediating Role of Intuitive Eating on the Association Between Self-control and Sociocultural Attitudes Towards Appearance Among Chinese College Students: a Cross-sectional Study
Authors: Sun Hong , Zhang Lin , Ma Jia-Ning , Guo Lei-Lei 
Published: August 2021

Abstract
Background: In China, people pay more and more attention to their body image, and most people have a negative attitude towards their appearance. This study aimed to explore the relationship of self-control, intuitive eating, and sociocultural attitudes towards appearance among Chinese college students. We further aimed to assess whether intuitive eating mediates the association between research self-control and sociocultural attitudes towards appearance.Methods: A cross-sectional study was conducted among 1510 college students in a medical university during September–December 2020. Self-administered questionnaires including Self-control Scale (SCS), Intuitive Eating Scale-2 (IES-2), and Sociocultural Attitudes Towards Appearance Questionnaire-3 (SATAQ-3) were completed by students. Correlation, multiple linear regression, and structural equation modeling were used in data analyses.Results：The mean sociocultural attitude towards appearance score was 43.91±7.74 among the participants. After adjusting for the demographic factors, self-control accounted for 17.4% of the variance in sociocultural attitudes towards appearance, while intuitive eating explained an additional 2.6% of the variance. Self-control had a direct effect(λ=-0.57,P<0.01)and an indirect effect(λ=-0.11,P<0.01) on sociocultural attitudes towards appearance. Intuitive eating functioned as a partial mediator in the relationship between self-control and sociocultural attitudes towards appearance among Chinese students. The mediation role accounted for 16.41% of the total effect. Conclusions：Improving self-control is good for adjusting appearance attitudes, and one way to do this is to suppress intuitive eating. College students should improve their self-control and use it in ways other than suppressing intuitive eating.
WITHDRAWN: Prevalence and Antimicrobial Susceptibility Pattern of Salmonella in Selected Export Abattoirs, East Shewa, Ethiopia
Authors: Alemu Abayneh , Regassa Fikru , Kebede Nigatu , Ambachew Rozina , Girma Musse , Sime Wondewosen Tsegaye 
Published: August 2021

Abstract
Background
Salmonella is one of the major causes of zoonotic foodborne pathogens in the world, with increasing concern for the emergence and spread of antimicrobial-resistant strains. In Ethiopia, the burden of Salmonella is still scarce in abattoirs.
Objectives
To determine the prevalence and antimicrobial susceptibility pattern of Salmonella in selected export abattoirs, East Shewa, Ethiopia.
Methods
A cross-sectional study was conducted from January 2020 to October 2020. A total of 345 samples were systematically included and out of which 150 carcass swabs (100 from goats and 50 from sheep carcass), 60 goat skin swabs, 60 knife swabs, and 75 human stool samples. The isolates were identified and characterized following standard bacteriological procedures and further confirmed by using Salmonella genus-specific primer by polymerase chain reaction. The isolates were subjected to antimicrobial susceptibility for 14 antibiotics using the Kirby-Bauer disk diffusion method. Data were entered and analyzed using STATA version 14. Fisher’s exact test was used to assess significant differences among the abattoirs and type of samples. P-value < 0.05 was considered as indicative of a statistical significance difference.
Results
Out of 345 total samples, 21(6.08%) were positive for Salmonella. The specific prevalence of Salmonella in carcass, skin, and knife swabs were 10(6.67%), 7(11.67%), and 4(6.67%) respectively. There were no statistically significant differences in the occurrence of Salmonella among export abattoirs, and types of samples (P > 0.05). Salmonella was not isolated from sheep carcass and human stool samples. Among the 21 molecular confirmed Salmonella isolates, 7(33.3%) were resistant to at least one antimicrobial agent and 2(9.04%) of isolates were resistant to two antibiotics, tetracycline, and streptomycin. All the isolates were 100% susceptible to kanamycin, chloramphenicol, cephalothin, gentamycin, and ceftriaxone.
Conclusion
Samples harbored Salmonella have significant public health impacts and hinder export performance. Thus, hygienic standards throughout the food chain process, surveillance systems, and one health approach are essential methods to minimize risks associated with the consumption of contaminated carcasses. Surveillance programs of antimicrobial usage in animals and animal products are important to ensure consumer safety.
Effects of Snow Manipulation on Larch Trees in the Taiga Forest Ecosystem in Northeastern Siberia
Authors: Shakhmatov Ruslan , Hashiguchi Shuhei , Maximov Trofim C. , Sugimoto Atsuko 
Published: August 2021

Abstract
Changes in winter precipitation (snow) may greatly affect vegetation by altering hydrological and biochemical processes. To understand the effects of changing snow cover depth and melt timing on the taiga forest ecosystem, a snow manipulation experiment was conducted in December 2015 at the Spasskaya Pad experimental larch forest in Eastern Siberia, which is characterized by a continental dry climate with extreme cold winters and hot summers. Variables including soil temperature and moisture, oxygen and hydrogen isotope ratios of soil moisture and stem water, foliar nitrogen and carbon contents and their isotopes, phenology, and soil inorganic nitrogen were observed at snow removal (SNOW−), snow addition (SNOW+), and CONTROL plots. After snow manipulation, the soil temperature at the SNOW− plot decreased significantly compared to the CONTROL and SNOW+ plots. At SNOW−, snowmelt was earlier and soil temperature was higher than at other plots during spring because of low soil moisture caused by less snowmelt water. Despite the earlier snowmelt and higher soil temperature in the SNOW− plot in the early growing season, needle opening and shoot elongation were delayed. Leaf chemistry also differed between the CONTROL and SNOW+ plots. The needle nitrogen content in the SNOW− plot was lower in the middle of July, whereas no difference was observed among the three plots in August. The soil inorganic nitrogen content of each plot corresponded to these results. The amount of soil ammonium was lower in the SNOW− plot than in the other plots at the end of July, however, once production started at the end of August, the amount of soil ammonium in the three plots was comparable. Extremely low soil temperatures in winter and freeze-thaw cycles in spring at the SNOW− plot may have affected these results.
Diversity, trait preferences, management and utilization of yams landraces (Dioscorea species): an orphan crop in DR Congo
Authors: Adejumobi Idris I , AGRE Paterne , Anautshu Didy O. , Adheka Joseph G. , Banbanota Mokonzi G. , Mozenga Jean-Claude L. , Komoy Joseph L. , Cipriano Inacio M. 
Published: August 2021

Abstract
BackgroundYam ( Dioscorea spp .) is cultivated in many villages of DR Congo as a means to sustain food security and alleviate poverty. However, the extent of the existing diversity has not been studied in details thus, considered as an orphan.MethodologyA survey covering 540 farmers in 54 villages was conducted in six major yam growing territories covering three provinces in DR Congo to investigate the diversity, management and utilization of yam landraces using pre-elaborate questionnaires.ResultsSubject to synonymy, a total of 67 landraces clones from five different species were recorded. Farmers’ challenges limiting yam production were poor tuber qualities (69%), harvest pest attack (7%), difficulty in harvesting (6%), poor soil status (6%). The overall diversity was moderate among the recorded yam germplasm maintained at the household level (1.32) and variability exist in diversity amongst the territories and provinces. Farmers’ in territories of Tshopo and Mongala provinces maintained higher level of germplasm diversity (2.79 and 2.77) compared to the farmers in territories of Bas-Uélé (1.67). Some yam landraces had limited abundance and distribution due to loss of production interest in many villages attributable to poisons contained hence, resulting in possible extinction. Farmers’ most preferred seed source for cultivation were backyard (43%) and exchange with neighboring farmers (31%) with the objective of meeting food security and generating income. In villages where yam production is expanding, farmers are relying on landraces with good tuber qualities and high yield even though they are late maturing.ConclusionThis study revealed the knowledge of yam genetic diversity, constraints to production and farmers’ preferences criteria as a guide for collection and conservation of yam genetic resources for yam improvement intervention.
Unity in Diversity - Food Plants and Fungi of Sakartvelo (Republic of Georgia), Caucasus
Authors: Bussmann Rainer W , Zambrana Narel Y Paniagua , Rahman Inayat Ur , Kikvidze Zaal , Sikharulidze Shalva , Kikodze David , Tchelidze David , Khutsishvili Manana , Batsatsashvili Ketevan 
Published: August 2021

Abstract
Background: The Republic of Georgia is part of the Caucasus biodiversity hotspot, and human agricultural plant use dates bat at least 6000 years. Over the last years lots of ethnobotanical research on the area has been published. In this paper we analyze the use of food plants in the 80% of Georgia not occupied by Russian forces. We hypothesized that, (1) given the long tradition of plant use, and the isolation under Soviet rule, plant use both based on home gardens and wild harvesting would be more pronounced in Georgia than in the wider region, (2) food plant use knowledge would be widely and equally spread in most of Georgia, (3) there would still be incidence of knowledge loss despite wide plant use, especially in climatically favored agricultural regions in Western and Eastern Georgia.Methods: From 2013 to 2019 we interviewed over 380 participants in all regions of Georgia not occupied by Russian forces and recorded over 19800 mentions of food plants. All interviews were carried out in the participants’ homes and gardens by native speakers of Georgian and its dialects (Imeretian, Rachian, Lechkhumian, Tush, Khevsurian, Psavian, Kakhetian), other Kartvelian languages (Megrelian, Svan) and minority languages (Ossetian, Ude, Azeri, Armenian, Greek). Results: The regional division was based primarily on historic provinces of Georgia, which often coincides with the current administrative borders. The total number of taxa, mostly identified to species, was 474. Taxonomically, the difference between two food plant groups - garden versus wild - was strongly pronounced even at family level. The richness of plant families was 66 versus 97 families in garden versus wild plants, respectively, and the difference was highly significant. Other diversity indices also unequivocally pointed to considerably more diverse family composition of wild versus garden plants as the differences between all the tested diversity indices appeared to be highly significant.Conclusions: Relationships among the regions in the case of wild food plants show a different and clearer pattern. In particular, adjacent regions cluster together (Kvemo Zemo Racha, and Zemo Imereti; Samegrelo, Guria, Adjara, Lechkhumi and Kvemo and Zemo Svaneti; Meskheti, Javakheti, Kvemo Kartli; Mtianeti, Kakheti, Khevsureti, Tusheti. Like in the case of the garden food plants, species diversity of wild food plants mentioned varied strongly. Climate severity and traditions of the use of wild food plants might play role in this variation. Overall food plant knowledge is widely spread all across Georgia, and broadly maintained
Understanding Etiology of Chromosome 21 Nondisjunction from Gene X Environment Models
Authors: Halder Pinku , Pal Upamanyu , Ganguly Agnish , Ghosh Papiya , Ray Anirban , Sarkar Sumantra , Ghosh Sujay 
Published: August 2021

Abstract
Maternal risk factors and their interactions with each other that associate chromosome 21 nondisjunction are intriguing and need incisive study to be resolved. We determined recombination profile of nondisjoined chromosome 21 and maternal genotypes for four selected polymorphic variants from the folate regulators genes stratifying the women according to the origin of segregation error and age at conception. We conducted association study for genotype and maternal habit of smoke less chewing tobacco with the incidence of Down syndrome birth. Additionally, we designed various logistic regression models to explore the effects of genotype, smokeless chewing tobacco habit, maternal age at conception and all possible interactions among them on chromosome 21 nondisjunction. We found folate regulator gene mutations are associated with maternal meiosis II error. Regression models revealed smokeless chewing tobacco and folate regulator mutant genotypes interact with each other to increase the risk of reduced and peri-centromeric recombination events on chromosome 21 that nondisjoined at meiosis II in the oocytes and the effect is maternal age independent. We inferred maternal polymorphic genotypes and habit of smokeless chewing tobacco interact with each other and increase the risk of meiosis II error in oocytes in maternal age-independent manner.
MAGI2-AS3 Modulates Proliferation, Apoptosis and Glycolysis in Acute Lymphoblastic Leukemia via miR-452-5p/FOXN3 Axis
Authors: Chen Xiao-Guang , Dou Bing-Hua , An Jin-Dou , Feng Song , Liu Na , Sheng Guang-Yao 
Published: August 2021

Abstract
Background: Long non-coding RNA MAGI2 antisense RNA 3 (MAGI2-AS3) has been identified as a tumor suppressor in various cancers. Acute lymphoblastic leukemia (ALL) is a prevalent kind of leukemia among children. In this study, we aimed at evaluate the role of MAGI2-AS3 in ALL and its underlying mechanisms.Methods: qPCR was adopted to determine MAGI2-AS3, miR-452-5p, and FOXN3 expression. The malignant properties of ALL cells were assessed by CCK8 assay and flow cytometry analysis. The glucose uptake, lactate production, and ATP level were measured to evaluate glycolysis. Western blotting was performed to detect PCNA, Bcl-2, Bax, and HK2 protein levels. The interaction between MAGI2-AS3/FOXN3 and miR-452-5p was validated by luciferase reporter assay. The in vivo growth of ALL cells was determined in xenograft model.Results: MAGI2-AS3 was strikingly down-regulated in ALL samples and cells. Overexpression of MAGI2-AS3 restrained growth, glycolysis and triggered apoptosis of ALL cells. Mechanistically, MAGI2-AS3 could sponge miR-452-5p to up-regulate FOXN3. Silencing of FOXN3 abolished the anti-tumor effect of MAGI2-AS3. Finally, MAGI2-AS3 suppressed the in vivo growth of ALL cells via modulating miR-452-5p/FOXN3 axis. Conclusions: Our findings demonstrate that MAGI2-AS3 delays the progression of ALL by regulating miR-452-5p/FOXN3 signaling pathway.