bluuebunny/crossref_metadata_2025_split huggingface dataset:
Counterhegemonic Mobilization and the Popularity of Backlash in Jujuy, Argentina
Authors: Pérez Marcos Emilio 
Published: October 2021

The dismantling of the Tupac Amaru Neighborhood Organization in Jujuy, Argentina, a major provider of jobs and services, generated limited resistance even among people who had benefited from it. Exploration of the role of counterhegemonic challenges in this process through ethnographic fieldwork, interviews with activists and scholars, newspaper archives, and social movement materials shows that the organization purposefully increased the visibility of stigmatized segments of Jujuy society, defying official narratives about the province. This strategy allowed the organization to recruit members and raise its national profile but also engendered the unified opposition of local elites, which used their control of strategic assets to turn public opinion against activists, portraying them as violent, corrupt, and above all foreign. El desmantelamiento de la Organización vecinal Túpac Amaru en Jujuy, Argentina, un importante proveedor de empleos y servicios, generó una resistencia limitada incluso entre las personas que se habían beneficiado de ella. Una exploración de trabajo de campo etnográfico en torno al papel que jugaron los desafíos contrahegemónicos en este proceso, así como entrevistas con activistas y académicos, y consulta de materiales hemerotécnicos y de movimientos sociales muestra que la organización aumentó deliberadamente la visibilidad de segmentos estigmatizados de la sociedad jujeña, desafiando las narrativas oficiales sobre la provincia. Esta estrategia permitió a la organización reclutar miembros y elevar su perfil nacional, pero también engendró la oposición unificada de las élites locales, que utilizaron su control de activos estratégicos para volver a la opinión pública en contra de los activistas, presentándolos como violentos, corruptos y, sobre todo, foráneos.
Internalizing Symptoms in Children Being Reared by Grandparents in Rural Appalachia: Risk and Protective Factors
Authors: Keller Peggy S. , Bi Shuang , Schoenberg Nancy 
Published: October 2021

The present study investigates factors associated with anxiety, depression, and stress in children being reared by their grandparents in rural Appalachia. Grandparent-headed households, in which grandparents have primary responsibility for care of children, are increasing in number. However, research is needed on child risk for internalizing symptoms in this context. Participants included 35 children aged 5–18 years and one of their custodial grandparents. Interviewers read questionnaires to grandparents and children assessing family functioning and child mental health and participants indicated their answers. Mean scores for child internalizing symptoms and stress were on the higher end of the scale of measurement. Lower grandparent positive parenting, grandparent not having formal custody of children, greater grandparent mental health issues, lower grandparent education, and lower financial status were correlated with greater child anxiety, depression, and stress. Results also indicated that correlates of children’s internalizing symptoms differed based on child sex and age.
Novel Surgical Technique in Active Bone Conduction: Minimally Invasive Approach to Fully Implantable Osseointegrated Implant
Authors: Hwa Tiffany Peng , Locketz Garrett , Ruckenstein Michael J. 
Published: October 2021

We report our experience using a novel minimally invasive surgical technique for implantation of a fully implantable active bone conduction implant. This was a retrospective review of 16 adults, including 10 women and 6 men. The mean age was 54 years. Hearing loss profiles included 8 with mixed hearing loss, 5 with conductive hearing loss, and 3 with single‐sided deafness. Nine patients underwent placement through the standard approach and 7 with the minimally invasive approach. There were no postoperative complications at a mean follow‐up of 6.5 months (SD, 4; range, 1.5‐12), and all patients received audiologic benefit with objective improvement in sound‐field thresholds upon activation. Mean operative time was shorter with the minimally invasive approach (64 vs 41 minutes, P =. 01). The fully implantable bone‐anchored auditory implant can be effectively placed via a minimally invasive incision, with potential benefits of decreased operative time, low risk for intra‐ and postoperative complications, and rapid healing.
Lung ultrasound and the role of lung aeration score in patients with acute respiratory distress syndrome on extracorporeal membrane oxygenation
Authors: Curry Stefanie , Tan Aileen , Gargani Luna , Ng Oriana , Roscoe Andrew , Salaunkey Kiran , Agrawal Bobby , Vuylsteke Alain , Fowles Jo-anne , Rubino Antonio 
Published: October 2021

Objective: This was a pilot study to determine the utility of daily lung ultrasound (LUS) in patients requiring veno-venous extracorporeal membrane oxygenation (VV-ECMO) for acute respiratory distress syndrome (ARDS). Design: This was a prospective, observational study. Setting: The study took place in the intensive care unit at Royal Papworth Hospital in Cambridge, UK. Participants: We recruited adult patients receiving VV-ECMO for ARDS. Interventions: All patients received a lung computed tomography (CT) scan and LUS on admission. Bedside chest radiography (CXR) and LUS were done on a daily basis until patients were decannulated. Measurements and main results: Daily LUS aeration scores were calculated according to the appearance of four defined patterns. An independent radiologist calculated corresponding scores for CT and CXR, retrospectively. These were checked for correlation with LUS aeration scores. There were statistically significant correlations between LUS versus CT ( r = 0.868, p = 0.002) and LUS versus CXR ( r = 0.498, p = 0.018) with good agreement and no evidence of proportional bias. LUS was able to detect 13.5% of pleural effusions and 54.2% of pneumothorax that were not picked up on CXR. In most of the patients who were weaned off VV-ECMO, a progressive reduction of LUS aeration scores corresponding to lung re-aeration was observed. Conclusions: LUS correlated with findings on CT and CXR for quantifying lung aeration and the clinical presentation of patients. LUS also picked up more pleural effusions and pneumothorax than CXR. Together with traditional imaging techniques, the routine use of LUS should be considered for this patient group.
Spike Glycoprotein Is Central to Coronavirus Pathogenesis-Parallel Between m-CoV and SARS-CoV-2
Authors: Saadi Fareeha , Pal Debnath , Sarma Jayasri Das 
Published: October 2021

Background: Coronaviruses (CoVs) are single-stranded, polyadenylated, enveloped RNA of positive polarity with a unique potential to alter host tropism. This has been exceptionally demonstrated by the emergence of deadly virus outbreaks of the past: Severe Acute Respiratory Syndrome (SARS-CoV) in 2003 and Middle East Respiratory Syndrome (MERS-CoV) in 2012. Summary: The 2019 outbreak by the new cross-species transmission of SARS-CoV-2 has put the world on alert. CoV infection is triggered by receptor recognition, membrane fusion, and successive viral entry mediated by the surface Spike (S) glycoprotein. S protein is one of the major antigenic determinants and the target for neutralizing antibodies. It is a valuable target in antiviral therapies because of its central role in cell-cell fusion, viral antigen spread, and host immune responses leading to immunopathogenesis. The receptor-binding domain of S protein has received greater attention as it initiates host attachment and contains major antigenic determinants. However, investigating the therapeutic potential of fusion peptide as a part of the fusion core complex assembled by the heptad repeats 1 and 2 (HR1 and HR2) is also warranted. Along with receptor attachment and entry, fusion mechanisms should also be explored for designing inhibitors as a therapeutic intervention. Key message: In this article, we review the S protein function and its role in mediating membrane fusion, spread, tropism, and its associated pathogenesis with notable therapeutic strategies focusing on results obtained from studies on a murine β-Coronavirus (m-CoV) and its associated disease process.
Association Between Regorafenib Dose and Efficacy Against Metastatic Colorectal Cancer in a Real-World Setting
Authors: Hatori Masahiro , Kawakami Kazuyoshi , Wakatsuki Takeru , Shinozaki Eiji , Kobayashi Kazuo , Aoyama Takeshi , Nakano Yasuhiro , Suzuki Kenichi , Yamaguchi Kensei , Hama Toshihiro 
Published: October 2021

The association between regorafenib dosage in the treatment of metastatic colorectal cancer (mCRC) and efficacy is currently not well established. It was previously reported that the regorafenib dose as prescribed is associated with efficacy, but doses in actual clinical settings have not been analyzed. We retrospectively analyzed patients with mCRC who had received regorafenib as third-line or later chemotherapy between May 2013 and June 2018. Patients who were not treated in the Pharmaceutical Outpatient Clinic for compliance assessment were excluded. Overall survival was calculated using the Kaplan–Meier method. Prognostic factors, including baseline demographics and adverse events, were evaluated using Cox proportional hazard models. A total of 176 patients were enrolled. By multivariate analysis, total dose until the second cycle < 3180 mg (HR = 1.71, 95% CI, 1.20–2.44, P = .003) was one of independent negative predictors of overall survival. Median survival times of the lower-dose group (< 3180 mg) and higher-dose group (≥ 3180 mg) were 5.8 and 7.6 months, respectively ( P = .045). The cumulative dose of regorafenib until the second cycle in patients with mCRC was associated with survival. It is important to individualize regorafenib dose in mCRC patients.
Three-Dimensional-Printed External Scaffolds Mitigate Loss of Volume and Topography in Engineered Elastic Cartilage Constructs
Authors: Dong Xue , Premaratne Ishani D. , Bernstein Jaime L. , Samadi Arash , Lin Alexandra J. , Toyoda Yoshiko , Kim Jongkil , Bonassar Lawrence J. , Spector Jason A. 
Published: October 2021

Objective A major obstacle in the clinical translation of engineered auricular scaffolds is the significant contraction and loss of topography that occur during maturation of the soft collagen-chondrocyte matrix into elastic cartilage. We hypothesized that 3-dimensional-printed, biocompatible scaffolds would “protect” maturing hydrogel constructs from contraction and loss of topography. Design External disc-shaped and “ridged” scaffolds were designed and 3D-printed using polylactic acid (PLA). Acellular type I collagen constructs were cultured in vitro for up to 3 months. Collagen constructs seeded with bovine auricular chondrocytes (BAuCs) were prepared in 3 groups and implanted subcutaneously in vivo for 3 months: preformed discs with (“Scaffolded/S”) or without (“Naked/N”) an external scaffold and discs that were formed within an external scaffold via injection molding (“Injection Molded/SInj”). Results The presence of an external scaffold or use of injection molding methodology did not affect the acellular construct volume or base area loss. In vivo, the presence of an external scaffold significantly improved preservation of volume and base area at 3 months compared to the naked group ( P < 0.05). Construct contraction was mitigated even further in the injection molded group, and topography of the ridged constructs was maintained with greater fidelity ( P < 0.05). Histology verified the development of mature auricular cartilage in the constructs within external scaffolds after 3 months. Conclusion Custom-designed, 3D-printed, biocompatible external scaffolds significantly mitigate BAuC-seeded construct contraction and maintain complex topography. Further refinement and scaling of this approach in conjunction with construct fabrication utilizing injection molding may aid in the development of full-scale auricular scaffolds.
Clinical Outcomes of the Traditional Latarjet Versus the Congruent Arc Modification for the Treatment of Recurrent Anterior Shoulder Instability: A Meta-analysis
Authors: Mengers Sunita R.P. , Knapik Derrick M. , Kaufman Matthew W. , Edwards Gary , Voos James E. , Gillespie Robert J. , Karns Michael R. 
Published: October 2021

Background: Few studies have compared clinical outcomes between the traditional Latarjet procedure for anterior shoulder instability and the congruent arc modification to the Latarjet procedure. Purpose: To systematically evaluate the literature for the incidence of recurrent instability, clinical outcomes, radiographic findings, and complications for the traditional Latarjet procedure and the congruent arc modification and to compare results of each search. Study Design: Systematic review; Level of evidence, 4. Methods: A systematic review and meta-analysis was conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. We included studies published between January 1990 and October 2020 that described clinical outcomes of the traditional Latarjet and the congruent arc modification with a follow-up range of 2 to 10 years. The difference in surgical technique was analyzed using a chi-square test for categorical variables, while continuous variables were evaluated using a Student t test. Results: In total, 26 studies met the inclusion criteria: 20 studies describing the traditional Latarjet procedure in 1412 shoulders, and 6 studies describing the congruent arc modification in 289 shoulders. No difference between procedures was found regarding patient age at surgery, follow-up time, Rowe or postoperative visual analog scores, early or late complications, return-to-sport timing, or incidence of improper graft placement or graft fracture. A significantly greater proportion of male patients underwent glenoid augmentation using the congruent arc modification versus traditional Latarjet ( P < .001). When comparing outcomes, the traditional Latarjet procedure demonstrated a lower incidence of fibrous union or nonunion ( P = .047) and broken, loose, or improperly placed screws ( P < .001), and the congruent arc modification demonstrated improved outcomes with regard to overall return to sport ( P < .001), return to sport at the same level ( P < .001), incidence of subluxation ( P = .003) or positive apprehension ( P = .002), and revision surgery for recurrent instability ( P = .027). Conclusion: Outcomes after the congruent arc modification proved at least equivalent to the traditional Latarjet procedure in terms of recurrent instability and return to sport, although early and late complications were equivalent. The congruent arc procedure may be an acceptable alternative to traditional Latarjet for the treatment of anterior shoulder instability with glenoid bone loss; however, long-term outcomes of this procedure are needed.
Risk Factors for Supraspinatus Tears: A Meta-analysis of Observational Studies
Authors: Zhao Jinlong , Luo Minghui , Liang Guihong , Wu Ming , Pan Jianke , Zeng Ling-feng , Yang Weiyi , Liu Jun 
Published: October 2021

Background: The pathogenesis of rotator cuff tears remains unclear, and there is a lack of high-quality evidence-based research on the risk factors for supraspinatus tears. Purpose: To explore 10 potential risk factors for supraspinatus muscle tears. Study Design: Systematic review; Level of evidence, 3. Methods: This review was conducted according to the MOOSE (Meta-analysis Of Observational Studies in Epidemiology) guidelines. PubMed, Embase, and Web of Science were searched for cohort, case-control and cross-sectional studies published before January 2021 on supraspinatus tears. The following potential risk factors were analyzed: age, body mass index, male sex, female sex, arm dominance, diabetes mellitus, smoking, hypertension, thyroid disease, and the critical shoulder angle (CSA). Risk ratios (RRs) or weighted mean differences (WMDs) of related risk were calculated. The Egger test was used to evaluate publication bias. Results: A total of 9 articles from 8 countries were included; among the 3240 patients, 687 were included in the supraspinatus tear group, and 2553 were included in the nonsupraspinatus tear group. The meta-analysis showed that older age (WMD, 3.36 [95% confidence interval (CI), 0.53-6.20]; P = .02), male sex (RR, 0.87 [95% CI, 0.78-0.97]; P = .01), smoking (RR, 2.21 [95% CI, 1.56-3.14]; P < .00001), diabetes (RR, 1.67 [95% CI, 1.03-2.70]; P = .04), hypertension (RR, 1.51 [95% CI, 1.16-1.97]; P = .002), and the CSA (WMD, 2.25 [95% CI, 1.39-3.12]; P < .00001) were risk factors for supraspinatus tears. Conclusion: Older age, male sex, smoking, diabetes, hypertension, and a higher CSA were found to be risk factors for supraspinatus tears in this meta-analysis review. Identifying risk factors for supraspinatus tears early can help clinicians identify these high-risk patients and choose appropriate treatments.
Current Perceptions of Diversity Among Head Team Physicians and Head Athletic Trainers: Results Across US Professional Sports Leagues
Authors: Wiggins Anthony J. , Agha Obiajulu , Diaz Agustin , Jones Kristofer J. , Feeley Brian T. , Pandya Nirav K. 
Published: October 2021

Background: Discrepancies in race, ethnicity, and sex among health care providers and their patients have been shown to affect the patient-provider relationship as well as the quality of care. Currently, minority and female representation among orthopaedic surgeons remains low. Given the large proportion of minority athletes and their degree of public visibility, professional sports serves as an important arena within which to analyze the diversity of health care providers. Purpose: To describe and evaluate the current level of diversity of head team physicians (HTPs) and head athletic trainers (ATCs), primarily in terms of race and sex, within men’s professional sports leagues in the United States. Study Design: Cross-sectional study. Methods: Five major US professional sports leagues were evaluated: National Basketball Association, National Football League, National Hockey League, Major League Soccer, and Major League Baseball. Publicly available data were collected to identify the HTPs and head ATCs for each team within these leagues. Two independent observers analyzed photographs and names of these individuals to determine his or her perceived race and sex, with disagreements being resolved by a third independent observer. Other physician data collected included graduate degree(s), specialty, and number of years in practice. Kappa coefficients (κ) were employed to evaluate interobserver reliability. Chi-square, Fisher exact, and t tests were used for statistical comparisons across leagues. Results: The κ values for perceived race were 0.85 for HTPs and 0.89 for head ATCs, representing near-perfect interobserver agreement. Minorities comprised 15.5% of HTPs and 20.7% of ATCs ( P = .24). Women comprised 3.9% of HTPs and 1.3% of head ATCs ( P = .017). The majority of HTPs were orthopaedic surgeons with medical doctorates. Female HTPs had significantly fewer years in practice compared with male HTPs (15.0 ± 4.9 vs 23.1 ± 9.6; P = .04). Conclusion: The lead physicians and athletic training providers for men’s professional sports teams demonstrated low rates of minority and female representation, denoting a highly visible area for discussing the role of increased diversity in health care.
A Haveli at the Agra Riverfront: Link to a Lost Heritage
Authors: Bansal Richa , Upadhyay Abhishek 
Published: October 2021

Agra was the capital of the Mughal Empire at its zenith, and the splendour of the city during this period can only be imagined. There is an abundance of royal buildings which are protected by the Government of India. There were other significant buildings too, housing the high nobility, away from both the royal quarters as well as the ordinary peoples’ houses. These have largely vanished, being large enough to attract builders as well as developers. The article describes and establishes the significance of one such rare traditional townhouse or mansion called ‘haveli’ located on the river Yamuna, Agra, in relation to a larger historical and cultural landscape. It also discusses the possibilities of conservation and management for protecting and enhancing the significance of the premises and planning for its sustainable development in future. The current edifice appears to be a coalescence of British and Mughal architecture with some local features. The building stands where similar-sized havelis stood during the Mughal period, housing high nobility. The architects of these buildings efficiently used the features of the river. With most such havelis having disappeared from the riverfront, this large residence-like edifice provides an interesting glimpse of the lost heritage. Fragments of information obtained from old maps and paintings, site surveys and some few research works have been joined together to reconstruct the origin and transformation vis-a-vis the present condition.
Psychosexual Problem in Remitted Psychiatric Patients
Authors: Shakya Dhana Ratna , Dhali Tapan Kumar , Bhattarai Sabeena , Sapkota Nidesh , Pandey Arun Kumar 
Published: October 2021

Background: Many patients and health literature, in general, allege that psychotropic agents cause sexual side effects. Objective: We intended to investigate this issue in a Nepalese clinical setting by estimating the prevalence of psychosexual problems among remitted psychiatric outpatients (on psychotropic medication) and by comparing it with that of a nonpsychiatric patient group (on nonpsychotropic medication). Methodology: In this hospital-based cross-sectional comparison study with purposive sampling, we collected the responses to a self-response questionnaire called “Arizona Sexual Experience Scale” from a total of 400 subjects: 100 male and 100 female consecutive consenting remitted psychiatric and dermatological outpatients, each with sex and marital status matching. We recorded pertinent information in the proforma and screened psychosexual problems with the Arizona Sexual Experience Scale after informed written consent. The problems in psychiatric and dermatological groups were compared. Results: We have more subjects of reproductive ages in both the psychiatric and dermatological groups. Depression, anxiety, and bipolar affective disorder were the most common diagnoses in the psychiatric patients, whereas eczema, fungal, immunologic, and allergic skin lesions/diseases were common in the dermatological patients. Both groups had comparable sexual dysfunction rates, both by overall and the criteria of ≥3 items with scores ≥4, whereas dermatological patients had more problems with criteria of ≥1 item with a score ≥5. Conclusions: Psychosexual dysfunction was more or less similar in frequency among both the psychiatric patients on psychotropic medication and dermatological patients on topical agents.