bluuebunny/crossref_metadata_2025_split huggingface dataset:
The direct/inverse interplay among 5-hydroxymethylcytosine (5hmC)-related biological pathways in gastrointestinal pan-cancer study
Authors: Moraveji Sayyed Sajjad , Khoshbakht Samane , Mokhtari Majid , Lanjanian Hosein , Masoudi-Nejad Ali 
Published: August 2021

Abstract
5-hydroxymethylcytosine (5-hmC) as an epigenetics marker has significant impacts on cancer progression. Identification of preserved 5-hmC-related subnetworks in pan-cancer studies could lead to a better understanding of gastrointestinal (GI) cancers insights. Here, we conducted a network-based analysis on 5-hmC values of GI cancers, including colon, gastric, pancreatic cancers, and healthy donors. The co-5-hmC network was reconstructed using the weighted gene coexpression network (WGCNA) method. The hierarchical clustering method was implemented to detect pan-cancer-related modules/subnetworks. The preservation of modules was assessed using another dataset. Modules were functionally enriched, and biological pathways were visualized using the ConsensuspathDB. A 5-hmC predictive model was determined using the elastic network classifier to distinguish cancer patients and healthy individuals. To assess the efficiency of the model the recursive operating characteristics (AUC) curve was computed using the 5 cross-fold validation and an external dataset as well. Three pan-cancer-related subnetworks were detected preserved in another dataset. The main biological pathways were the cell cycle, apoptosis, and extracellular matrix (ECM) organization. The direct association between the cell cycle and ECM, the inverse association between apoptosis and ECM organization, and the inverse association between the cell cycle and ECM organization were detected for the 5-hmC marker in GI cancers. The AUC of 92% (0.73-1.00) was detected for the predictive model. In conclusion, the intricate association among biological pathways of ECM organization, Cell cycle, and apoptosis in GI cancers might be the consequence of epigenetics aberration; such findings could be beneficial in precision medicine using liquid biopsy in early stages.
piRNA/ PIWI protein complex as potential biomarkers in sporadic amyotrophic lateral sclerosis
Authors: Abdelhamid Rehab F. , Ogawa Kotaro , Beck Goichi , Ikenaka Kensuke , Takeuchi Eriko , Yasumizu Yoshiaki , Jinno Jyunki , Kimura Yasuyoshi , Baba Kousuke , Nagai Yoshitaka , Okada Yukinori , Saito Yuko , Murayama Shigeo , Mochizuki Hideki , Nagano Seiichi 
Published: August 2021

Abstract
The pathological hallmark in the majority of amyotrophic lateral sclerosis (ALS) cases is the mislocalization and aggregation of TAR DNA-binding protein 43 (TDP-43), an RNA-binding protein. Several studies have attributed disease processes of ALS to abnormal RNA metabolism. However, dysregulated biogenesis of RNA, especially non-coding RNA (ncRNA), is poorly understood. To resolve it, RNA-Seq, biochemical and immunohistochemical analyses were performed on sporadic ALS (sALS) and control postmortem brain samples. Here we report perturbation of ncRNA biogenesis in PIWI-interacting RNA (piRNA) in several sALS brain samples associated with TDP-43 pathology. In addition, we confirmed the dysregulation of two PIWI homologs, PIWI-like-mediated gene silencing 1 (PIWIL1) and PIWIL4, which bind to piRNAs to regulate their expression. PIWIL1 was mislocalized and co-localized with TDP-43 in motor neurons of sporadic ALS lumbar cords. Our results imply that dysregulation of piRNA, PIWIL1, and PIWIL4 is linked to pathogenesis of ALS. Based on these results, piRNAs and PIWI proteins are expected to be potential diagnostic biomarkers and therapeutic targets of ALS.
Ni-Fe phosphide deposited carbon felt as free-standing bifunctional catalyst electrode for urea electrolysis
Authors: Yun Woo Hyun , Das Gautam , Kim Bohyeon , Park Bang Ju , Yoon Hyon Hee , Yoon Young Soo 
Published: August 2021

Abstract
A free-standing catalyst electrode for the urea oxidation reaction (UOR) and hydrogen evolution reaction (HER) in a urea electrolysis cell was synthesized by electroplating a Ni-Fe alloy onto carbon felt, followed by phosphidation (P-NiFe@CF). The prepared P-NiFe@CF catalyst consisted of Ni5P4, NiP2, and FeP with 3D flower-like P-NiFe architecture on CF. P-NiFe@CF exhibited excellent electrocatalytic activity for the UOR (demanding only 1.44 V (vs. RHE) to achieve 200 mA cm −2), and for the HER with a low overpotential of 0.065 V (vs. RHE) at 10 mA cm−2, indicating its feasibility as a bifunctional catalyst electrode for urea electrolysis. A urea electrolysis cell with P-NiFe@CF as both the free-standing anode and cathode generated a current density of 10 mA cm−2 at a cell potential of 1.42 V (vs. RHE), which is considerably lower than that of water electrolysis, and also lower than previously reported values. The results indicate that the P-NiFe@CF catalyst electrodes can be used as free-standing bifunctional electrodes for urea electrolyzers.
Telehealth Interventions and Outcomes Across Rural Communities in the United States: Narrative Review
Authors: Butzner Michael , Cuffee Yendelela 
Published: August 2021

Background
In rural communities, there are gaps in describing the design and effectiveness of technology interventions for treating diseases and addressing determinants of health.

Objective
The aim of this study is to evaluate literature on current applications, therapeutic areas, and outcomes of telehealth interventions in rural communities in the United States.

Methods
A narrative review of studies published on PubMed from January 2017 to December 2020 was conducted. Key search terms included telehealth, telemedicine, rural, and outcomes.

Results
Among 15 included studies, 9 studies analyzed telehealth interventions in patients, 3 in health care professionals, and 3 in both patients and health care professionals. The included studies reported positive outcomes and experiences of telehealth use in rural populations including acceptability and increased satisfaction; they also noted that technology is convenient and efficient. Other notable benefits included decreased direct and indirect costs to the patient (travel cost and time) and health care service provider (staffing), lower onsite health care resource utilization, improved physician recruitment and retention, improved access to care, and increased education and training of patients and health care professionals.

Conclusions
Telehealth models were associated with positive outcomes for patients and health care professionals, suggesting these models are feasible and can be effective. Future telehealth interventions and studies examining these programs are warranted, especially in rural communities, and future research should evaluate the impact of increased telehealth use as a result of the COVID-19 pandemic.
Assessing the soil color by traditional method and a smartphone: a comparison
Authors: Raulino Gabriela De Castro , Oliveira Lucas De Sousa , Nascimento Icaro Vasconcelos , Da Silva Cillas Pollicarto , Lobato Márcio Godofrêdo , Alencar Thiago Leite , Toma Raul Shiso , Da Silva Francisca Gleiciane , Mota Jaedson Cláudio 
Published: August 2021

Based on the hypothesis that there is a high agreement between pedologists and a smartphone application in the assessment of soil color; the objective was to compare the perceptions of pedologists and an application in obtaining the color of an Argissolo [Lixisol] (A, E and B horizons). Ten aggregates of each horizon were collected. In a single day, under the same lighting conditions, three pedologists described the color components (hue, value, and chroma) of each aggregate (dry and moist soil) using the Munsell soil color chart. Each one of the ten aggregates, from each horizon, was photographed (dry and moist soil sequence) using the camera of a Motorola Moto G4 Plus smartphone. The distance of the camera to the aggregates was 25 ± 5 cm. Also, each aggregate was placed on a white sheet of A4 size paper (background). The application used was Soil Analysis Pro. The percentage of agreement between pedologists and application was obtained concerning hue, value, and chroma. The data were subjected to analysis of variance, in a completely randomized design, with ten replicates. Action Stat® software was used for statistical analysis. It was concluded that the agreement between pedologists and the smartphone application was medium for hue and chroma and low for value. For the dry soil condition, there is a high agreement between pedologists and the smartphone application, especially in the perception of hue and chroma. Thus, the smartphone application has the potential to be used in routine descriptions of soil color.
Enhancing student retention
Authors: Barroso Tanoira Francisco Gerardo 
Published: August 2021

In a study I conducted in local private higher education institutions, it was observed that the most important reasons for student retention are outstanding personalized attention by tutors, school authorities, staff and professors, followed by the economic factor and academic achievement. So, quality in attention is the first step for creating a positive learning environment for students to engage in their own learning, making schools become places where talent and opportunities meet. Then, more than thinking in retaining students through financial strategies, marketing efforts or trying to amaze them with impressive buildings and facilities, there must be better academic tutoring and vocational orientation, less students per tutor and more effectiveness for solving their problems, also eliminating useless remedial courses. Close and frequent relation with school authorities is very important for enhancing confidence.
Determinación de la vida útil de la tortilla de maíz adicionada con aceite esencial de tomillo a través de pruebas de vida acelerada
Authors: Meléndez Pastrana Inocente Yuliana , Rodríguez Morachis Manuel Alonso , Rodríguez Medina Manuel Arnoldo , Zorrilla Briones Francisco 
Published: August 2021

La tortilla de maíz es uno de los principales componentes en la dieta del mexicano. En el proceso de elaboración, se emplean diferentes conservadores químicos, como el propionato de sodio y algunos acidificantes para incrementar la vida de anaquel de la tortilla de maíz. En México, al no haber una regulación bien definida sobre la adición de conservadores químicos, no existe protección hacia el consumidor. De aquí que esta investigación propone la adición de aceite esencial de tomillo como bioconservador. La metodología utilizada consistió en dos experimentos por separado: uno utilizando una concentración de 0.09 % de aceite esencial de tomillo y otro utilizando propionato de sodio a 0.2 %. Así, usando el modelo de Arrhenius, se calculó la vida útil de la tortilla de maíz adicionada con aceite esencial de tomillo a 21 °C y se encontró que fue de 104.3356 horas, mientras que para la tortilla adicionada con propionato de sodio, bajo las mismas condiciones, se obtuvo una vida de 75.3300 horas. Asimismo, mediante el factor de aceleración, se obtuvo un mejor desempeño del aceite esencial de tomillo como conservador orgánico, en contraste con el propionato de sodio. En suma, no solo mejora la inocuidad alimentaria del producto en cuanto a su vida de anaquel, sino que el aceite esencial de tomillo puede reemplazar a un conservador cancerígeno en la preparación de tortillas de maíz.
BELAJAR BERSAMA COVID-19:REVIEW IMPELEMENTASI, TANTANGAN DAN SOLUSI PEMBELAJARAN DARING PADA GURU-GURU SMP
Authors: Purwasih Ratni , Elshap Dewi Safitri 
Published: August 2021

Adapun tujuan dari penelitian ini adalah untuk mengetahui implementasi pembelajaran dalam jaringan (daring) serta tantangan apa saja yang menjadi pendukung dan penghambat guru dalam proses pembelajaran daring untuk guru sekolah menengah pertama dan solusinya. Metode penelitian yang digunakan adalah kualitatif deskriptif dengan pengambilan sampel secara purposive sampling. Teknik pengumpulan data melalui kuesioner dan wawancara terstruktur. Subjek penelitian ini adalah 28 guru matematika yang mengajar di berbagai sekolah di Kabupaten Bandung, Jawa Barat. Metode penelitian yang di gunakan adalah deskriptif kualitatif. Instrumen penelitian ini adalah wawancara dan kuisioner melalui google form. Teknik pengumpulan data yang digunakan dalam penelitian ini berupa angket terbuka, wawancara terstruktur dan dokumentasi. Langkah-langkah penelitian meliputi pengumpulan data, reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa guru-guru matematika dalam implementasi pembelajaran menggunakan berbagai flatform media sebagai alat bantu pembelajaran daring seperti google meet, google classroom dan E-learning;, respon siswa terhadap pembelajaran daring yaitu postif serta pembelajaran daring memiliki tantangan/kendala, baik dari aspek sumber daya manusia, sarana-prasarana, dan teknis implementasinya.
Keefektifan Model Pembelajaran Example Non Example dengan menggunakan CD Pembelajaran Terhadap Prestasi Belajar Matematika Ditinjau dari Kemampuan Awal Siswa Pada Materi Pokok Bangun Ruang Sisi Datar
Authors: Fitriani Latfiya , Dwi Wahyuningsih Eleonora , Ponoharjo Ponoharjo 
Published: August 2021

Penelitian ini bertujuan untuk mengetahui apakah ada perbedaan prestasi belajar matematika siswa yang pembelajarannya menggunakan model Example Non Example dengan menggunakan CD Pembelajaran dengan model Ekspositori.Pengambilan sampel menggunakan teknik cluster random sampling siswa kelas VIII Semester Genap Tahun Ajaran 2016/2017. Sampel yang diambil sebanyak dua kelas sebagai kelas eksperimen, dan dua kelas sebagai kelas kontrol. Metode pengumpulan data yang digunakan adalah dokumentasi dan tes. Instrumen penelitian berupa tes prestasi dan telah teruji validitas dan reliebilitas pada taraf signifikansi 5%. Teknik analisis data menggunakan anava dua arah dan uji t pihak kanan yang sebelumnya dilakukan uji prasyarat hipotesis terlebih dahulu yaitu uji normalitas dan uji homogenitas. Hasil penelitian menunjukan bahwa, terdapat perbedaan model Example Non Example dengan menggunakan CD Pembelajaran dengan model ekspositori terhadap prestasi belajar matematika sehingga didapat prestasi belajar matematika siswa yang mempunyai kemampuan awal tinggi dengan proses pembelajarannya menggunakan model Example Non Example dengan menggunakan CD pembelajaranlebih efektif daripada yang menggunakanmodel ekspositori dan prestasi belajar matematika siswa yang mempunyai kemampuan awal rendah dengan proses pembelajarannya menggunakan model ekspositori lebih efektif daripada yang menggunakan Example Non Example dengan menggunakan CD pembelajaran
KEEFEKTIFAN MODEL PEMBELAJARAN SNOWBALL THROWING TERHADAP MOTIVASI BELAJAR DAN PRESTASI BELAJAR MATEMATIKA
Authors: Bawazir Mahbub , Suwandono  , Rokhman Moh. Shaefur 
Published: August 2021

Penelitian pada peserta didik kelas VII SMP Negeri 1 Kramat bertujuan untuk mendeskripsikan: 1) Prestasi belajar matematika peserta didik yang diajar model pembelajaran snowball throwing yang nilainya diatas 60 melampaui 75%, 2) Ada perbedaan motivasi belajar dan prestasi belajar matematika antara peserta didik yang diajar model pembelajaran Snowball Throwing dengan model pembelajaran konvensional, 3) Motivasi belajar dan prestasi belajar matematika peserta didik yang diajar model pembelajaran Snowball Throwing lebih baik daripada model pembelajaran konvensional. Populasi dalam penelitian ini adalah seluruh peserta didik Kelas VII semester II SMP Negeri 1 Kramat Kabupaten Tegal 2016/2017 yang terdiri atas 326 peserta didik. Sampel dalam penelitian ini diambil dengan teknik purposive sampling yang terdiri atas 181 peserta didik. Metode pengumpulan data yang digunakan adalah teknik dokumentasi, angket, dan tes. Analisis data yang digunakan adalah (1) uji proporsi pada hipotesis 1, (2) uji manova one-way pada hipotesis 2, (3) uji 2 – Hotelling pada hipotesis 3. Dimana sebelumnya data berdistribusi normal dan homogen. Hasil penelitian ini diperoleh: 1) Prestasi belajar matematika peserta didik yang diajar model pembelajaran snowball throwing yang nilainya diatas 60 melampaui 75%, 2) Ada perbedaan motivasi belajar dan prestasi belajar matematika antara peserta didik yang diajar model pembelajaran Snowball Throwing dengan model pembelajaran konvensional, 3) Motivasi belajar dan prestasi belajar matematika peserta didik yang diajar dengan model pembelajaran Snowball Throwing lebih baik daripada model konvensional.
Keefektifan Model Pembelajaran Student Facilitator And Explaining dipadukan Metode Kumon Terhadap Prestasi Belajar Dan Kemampuan Komunikasi Matematis
Authors: Hariyanto Ahmad Teguh , Suwandono  , Ahmadi  
Published: August 2021

Penelitian ini bertujuan untuk mendeskripsikan: 1) Ada perbedaan prestasi belajar matematika dan kemampuan komunikasi matematis antara peserta didik yang diajar menggunakan model pembelajaran Student Facilitator and Explaining dipadukan metode Kumon dengan peserta didik yang diajar menggunakan model pembelajaran Inquiry Learning, 2) Prestasi belajar matematika dan kemampuan komunikasi matematis peserta didik yang diajar menggunakan model pembelajaran Student Facilitator and Explaining dipadukan metode Kumon lebih baik daripada peserta didik yang diajar menggunakan model pembelajaran Inquiry Learnin. Teknik analisis data yang digunakan adalah Uji Proporsi Pihak Kanan, Uji Manova, dan Uji Hotelling. Hasil penelitian ini adalah: 1) Ada perbedaan prestasi belajar matematika dan kemampuan komunikasi matematis antara peserta didik yang diajar menggunakan model pembelajaran Student Facilitator and Explaining dipadukan metode Kumon dengan peserta didik yang diajar menggunakan model pembelajaran Inquiry Learning, 2) Prestasi belajar matematika dan kemampuan komunikasi matematis peserta didik yang diajar menggunakan model pembelajaran Student Facilitator and Explainingdipadukan metode Kumon lebih baik dari pada peserta didik yang diajar menggunakan model pembelajaran Inquiry Learning.
Guillain-Barré syndrome following COVID-19 infection in an elderly patient: a case report
Authors: Luvsannyam Enkhmaa , Jayaraman Arathi , Jain Molly Sanjay , Sharma Karan , Somagutta Manoj Reddy , Yallapragada Rathna Kumar 
Published: August 2021

Background:
Coronaviruses can affect multiple body systems and respiratory failure is the most common complication. Since the outbreak of coronavirus disease-2019 (COVID-19) in January 2020, the association between COVID-19 and Guillain-Barre syndrome (GBS) has been growing. GBS is known to be triggered by an antecedent infection, mostly viruses.

Case Presentation:
We present a case of GBS in an 83-year-old female patient with a confirmed COVID-19 infection. The patient initially presented with fever, cough, and fatigue. She was treated with intravenous fluid and symptomatic treatment and discharged home after stabilization. Several weeks after her initial encounter, she experienced bilateral paresthesias as well as numbness and tingling in her lower extremities. The patient’s neurological symptoms were not alleviated with standard intravenous immune globulin (IVIG) therapy; however, her symptoms significantly improved with subsequent plasmapheresis therapy.

Conclusion:
Based on the emerging evidence of recent studies, there is a possible connection between COVID-19 and GBS. Clinicians should be aware of the neurological manifestations of COVID-19 infection. Early diagnosis and proper treatment of COVID-19 and its neurological symptoms are crucial to increase the chance of a successful recovery.
Maize cultivation in the Kaluga region for rolled grain conservation
Authors: Кузнецова Л.В. , Мазуров В.Н. 
Published: August 2021

В Калужской области в условиях инновационного развития животноводческой отрасли отмечено увеличение количества ферм с круглогодовым стойловым содержанием животных, которое требует качественных энергетических кормов собственного производства. В этом направлении актуально использование кукурузного корма в виде не только силоса, но и зерна. В результате многолетнего изучения в Калужском НИИСХ более 70 сортов и гибридов кукурузы зарубежной и отечественной селекции установлено, что в условиях области возможно выращивание кукурузы на силос, зерностержневую массу и зерно. Урожайность зелёной массы изучаемых гибридов составляла от 30 до 75 т/га, зерна — от 4 до 11 т/га. Произведён расчёт типовой научно обоснованной технологической карты возделывания кукурузы на зерно с последующим химическим консервированием плющеного зерна, показана экономическая эффективность технологии на примере Калужской области. Расчёты выполнены на основе использующихся в регионе технологий возделывания этой культуры и приготовления консервированного плющеного зерна в полимерном рукаве. При определении себестоимости продукции произведён расчёт потребности в денежных средствах по статьям затрат на выращивание кукурузы и приготовление её с помощью химического консервирования плющеного зерна. На основе полученных результатов установлено, что на производство 700 т плющеной консервированной кукурузы, при урожайности культуры 7 т/га, потребуется 5782,2 тыс. руб. (в ценах 2018 года). Для оценки вариабельности технологии с точки зрения рисков получения меньшей или большей урожайности нормативы затрат рассчитаны на 1 га и 1 т продукции при урожайности кукурузы на зерно 5, 7, 9 т/га. Полученные данные позволяют утверждать, что с ростом урожайности кукурузы от 5 до 9 т/га себестоимость 1 т продукции снижается с 11 405 до 6513 руб. (в ценах 2018 года).
The number of farms keeping livestock indoors all year round grew in the Kaluga region. Therefore, local forage production of high quality and nutrition became an important issue. Maize grain is a promising feed along with corn silage. Kaluga Agricultural Research Institute tested over 70 foreign and domestic maize varieties and hybrids for several years proving crop applicability for silage production, cob mass and grain. Hybrids produced 30‒75 t ha-1 of green mass and 4‒11 t ha-1 of grain. A flow chart for maize rolled grain conservation was developed; economic efficiency of the technology was proved. Calculations were performed according to regional technology of maize cultivation and rolled grain conservation in plastic bag. Prime costs for rolled grain conservation were evaluated. Production and conservation of 700 t of maize rolled grain requires 5782.2 rubles (2018) when crop yielding 7 t ha-1. To consider the risk of yield variation costs for 1 ha and 1 t of grain were calculated under grain productivity of 5, 7, 9 t ha-1. Yield increase from 5 to 9 t ha-1 reduces prime costs for 1 t of grain mass from 11 405 to 6513 rubles (2018).