bluuebunny/crossref_metadata_2025_split huggingface dataset:
Invasion disharmony in the global biogeography of native and non‐native beetle species
Authors: Liebhold Andrew M. , Turner Rebecca M. , Blake Rachael E. , Bertelsmeier Cleo , Brockerhoff Eckehard G. , Nahrung Helen F. , Pureswaran Deepa S. , Roques Alain , Seebens Hanno , Yamanaka Takehiko 
Published: July 2021

AbstractAimThe concept of “island disharmony” has been widely applied to describe the systematic over‐ and under‐representation of taxa on islands compared to mainland regions. Here, we explore an extension of that concept to biological invasions. We compare biogeographical patterns in native and non‐native beetle (Coleoptera) assemblages from around the world to test whether beetle invasions represent a random sample of species or whether some families are more prone to invade than others.LocationGlobal.MethodsNumbers of non‐native beetle species established in ten regions worldwide were compared with the land area of each region. The distribution of species among families was compared with the distribution among families for all species native to the same region and with the distribution among families for the global pool of all known beetle species. Ordination analysis was used to characterize differences among native and non‐native assemblages based upon the distribution of species among families.ResultsWe report a total of 1,967 non‐native beetle species across all ten regions, and a classic log–log relationship between numbers of species per region and land area though relationships are generally stronger for native assemblages. Some families (e.g., Dermestidae and Bostrichidae) are over‐represented and others (e.g., Carabidae, Scarabaeidae and Buprestidae) are under‐represented in non‐native assemblages. The distribution of species among families is generally similar among native assemblages with greatest similarities among nearby regions. In contrast, non‐native species assemblages are more similar to each other than to native species assemblages.Main conclusionsCertain families are over‐represented, and others are under‐represented in non‐native beetle assemblages compared to native assemblages, indicating “invasion disharmony” in the global representation of beetle families. Similarities in composition among non‐native assemblages may reflect unobserved associations with invasion pathways and life‐history traits that shape invasion success of different insect groups.
Physical rehabilitation interventions in children with acquired brain injury: a scoping review
Authors: Gmelig Meyling Christiaan , Verschuren Olaf , Rentinck Ingrid R , Engelbert Raoul H H , Gorter Jan Willem 
Published: July 2021

AimTo synthesize the evidence about the characteristics (frequency, intensity, time, type) and effects of physical rehabilitation interventions on functional recovery and performance in daily functioning in children and young people with acquired brain injury (ABI), including traumatic brain injuries (TBI) and non‐TBI, during the subacute rehabilitation phase.MethodUsing scoping review methodology, a systematic literature search was performed using four databases. Articles were screened by title and abstract and data from eligible studies were extracted for synthesis.ResultsNine of 3009 studies were included. The results demonstrated a variety of intervention characteristics: frequency varied between 1 and 7 days per week; time of intervention varied between 25 minutes and 6 hours a day; intervention types were specified in seven studies; and none of the included studies reported details of intensity of intervention. All studies reported positive results on the International Classification of Functioning, Disability and Health: Children and Youth (ICF‐CY) levels of body function and activities after the intervention period, with study designs of included studies being cohort studies without concurrent controls (n=7) or case reports (n=2).InterpretationInconsistency in results hampers generalizability to guide clinical practice. Physical interventions during subacute rehabilitation have potential to improve functional recovery with intervention characteristics as an important factor influencing its effectiveness. Future well‐designed studies are indicated to gain knowledge and optimize rehabilitation practice in paediatric ABI and high‐quality research including outcomes across all ICF‐CY domains is needed.
The evolving story of incretins (GIP and GLP‐1) in metabolic and cardiovascular disease: A pathophysiological update
Authors: Nauck Michael A. , Quast Daniel R. , Wefers Jakob , Pfeiffer Andreas F. H. 
Published: July 2021

AbstractThe incretin hormones glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) have their main physiological role in augmenting insulin secretion after their nutrient‐induced secretion from the gut. A functioning entero‐insular (gut‐endocrine pancreas) axis is essential for the maintenance of a normal glucose tolerance. This is exemplified by the incretin effect (greater insulin secretory response to oral as compared to “isoglycaemic” intravenous glucose administration due to the secretion and action of incretin hormones). GIP and GLP‐1 have additive effects on insulin secretion. Local production of GIP and/or GLP‐1 in islet α‐cells (instead of enteroendocrine K and L cells) has been observed, and its significance is still unclear. GLP‐1 suppresses, and GIP increases glucagon secretion, both in a glucose‐dependent manner. GIP plays a greater physiological role as an incretin. In type 2‐diabetic patients, the incretin effect is reduced despite more or less normal secretion of GIP and GLP‐1. While insulinotropic effects of GLP‐1 are only slightly impaired in type 2 diabetes, GIP has lost much of its acute insulinotropic activity in type 2 diabetes, for largely unknown reasons. Besides their role in glucose homoeostasis, the incretin hormones GIP and GLP‐1 have additional biological functions: GLP‐1 at pharmacological concentrations reduces appetite, food intake, and—in the long run—body weight, and a similar role is evolving for GIP, at least in animal studies. Human studies, however, do not confirm these findings. GIP, but not GLP‐1 increases triglyceride storage in white adipose tissue not only through stimulating insulin secretion, but also by interacting with regional blood vessels and GIP receptors. GIP, and to a lesser degree GLP‐1, play a role in bone remodelling. GLP‐1, but not GIP slows gastric emptying, which reduces post‐meal glycaemic increments. For both GIP and GLP‐1, beneficial effects on cardiovascular complications and neurodegenerative central nervous system (CNS) disorders have been observed, pointing to therapeutic potential over and above improving diabetes complications. The recent finding that GIP/GLP‐1 receptor co‐agonists like tirzepatide have superior efficacy compared to selective GLP‐1 receptor agonists with respect to glycaemic control as well as body weight has renewed interest in GIP, which previously was thought to be without any therapeutic potential. One focus of this research is into the long‐term interaction of GIP and GLP‐1 receptor signalling. A GLP‐1 receptor antagonist (exendin [9‐39]) and, more recently, a GIP receptor agonist (GIP [3‐30] NH2) and, hopefully, longer‐acting GIP receptor agonists for human use will be helpful tools to shed light on the open questions. A detailed knowledge of incretin physiology and pathophysiology will be a prerequisite for designing more effective incretin‐based diabetes drugs.
Chest pain and dyspnea in a young man
Authors: Ramakumar Venkatakrishnan , Farooqui Faraz Ahmed 
Published: July 2021

AbstractA 27‐year‐old man presented with sudden onset chest pain associated with dyspnea for the preceding 1 week. He also reported typical angina for the past 3 months. Clinical examination revealed a continuous murmur in the upper left parasternal region. Echocardiography revealed a ruptured left sinus of Valsalva aneurysm communicating with the left atrium. CT angiogram confirmed a ruptured large aneurysm of the left sinus of Valsalva freely communicating with the left atrium via a long fistulous tract. Additionally, the tract resulted in partial compression of the left main coronary artery. A ruptured sinus of Valsalva aneurysm represents an important differential in young adults presenting with acute onset chest pain and heart failure. Fistulous tracts arising from the left sinus may result in compression of the left coronary system and sudden cardiac death making this a unique entity to recognize.
Is there an ‘ideal’ diet for patients with NAFLD?
Authors: Pugliese Nicola , Plaz Torres Maria Corina , Petta Salvatore , Valenti Luca , Giannini Edoardo G. , Aghemo Alessio 
Published: July 2021

AbstractNonalcoholic fatty liver disease (NAFLD) is a growing epidemic that encompasses three distinct clinical phenotypes: uncomplicated fatty liver, nonalcoholic steatohepatitis (NASH) and NASH‐related cirrhosis with its complications, including hepatocellular carcinoma. To date, no pharmacological treatments have been approved and lifestyle modifications including reduced caloric intake targeting a 7%‐10% weight loss from baseline assessment represent the standard approach. Mediterranean diet has been recommended as the best dietary pattern since it is easy to follow and, independently of caloric intake its nutritional components have beneficial metabolic effects that not only improve steatosis but also risk factors for cardiovascular events, the leading cause of morbidity/mortality in individuals with NAFLD. Other dietary patterns such as ketogenic diet and Dietary Approach to Stop Hypertension (DASH) diet can be used in patients with NAFLD. Recently, intermittent fasting diets have gained popularity among healthy individuals and have been proposed as a safe and effective treatment for the metabolic syndrome in experimental and in a few human studies. In this narrative review, we aim to summarize the evidence for the available dietary approaches for patients with NAFLD.
Variability in activity differs between castes in the ant Linepithema humile
Authors: Sanmartín‐Villar Iago , Csata Enikő , Jeanson Raphaël 
Published: July 2021

1. The study of behavioural variability has a long research tradition in social insects. Because of their contribution to division of labour, between‐individual variations have been mostly studied within the worker caste. In contrast, the level of behavioural variation between queens has been much less studied.2. In ants, a high level of behavioural variability could contribute to the ecological success of invasive species by favouring the colonisation of new environments.3. In the invasive ant species Linepithema humile (Mayr), we used a standardised test to assess plasticity and predictability in activity level between workers and queens.4. We found that only queens, not workers, displayed between‐individual variability in plasticity.5. We propose that the behavioural variability of queens could be an asset favouring the adaptation of invasive ant species to changing environments.
Clinical and psychological correlates of insight dimensions in patients with early psychosis
Authors: Kam Tze Kwan , Lui Tsz Ting , Lau Fu Chun , Chan Kit Wa , Lee Ho Ming , Hui Lai Ming , Suen Yi Nam , Lui Sai Yu , Chen Eric , Chang Wing Chung 
Published: July 2021

AbstractAimTo investigate correlates of insight dimensions in Chinese adult patients with early psychosis.MethodsInsight dimensions including awareness of mental disorder (AMD), illness consequences (AIC) and medication effect (AME) were measured. A wide array of variables encompassing demographics, premorbid adjustment, onset profiles, symptomatology, treatment characteristics and psychological factors were comprehensively assessed.ResultsOf 130 participants, 53.1%, 47.7% and 56.2% were categorized with good AMD, AIC and AME, respectively. Good AMD was associated with female gender, fewer positive and disorganization symptoms, more severe depression and greater self‐stigma. Good AIC was related to female gender, more severe depression and greater self‐stigma. Younger age of onset, fewer positive symptoms and greater service satisfaction associated with good AME.ConclusionsPoor insight is prevalent in early psychosis. Differential relationships of insight dimensions with other illness variables underscore the importance of multidimensional approach in insight evaluation, and suggest potential treatment target for insight enhancement.
Asymmetric left–right hippocampal glutamatergic modulation of cognitive control in ApoE‐isoform subjects is unrelated to neuroinflammation
Authors: Zhang Hui , Chiu Pui Wai , Ip Isaac , Liu Tianyin , Wong Gloria Hoi Yan , Song You‐Qiang , Wong Savio Wai Ho , Herrup Karl , Mak Henry Ka Fung 
Published: July 2021

AbstractThe glutamatergic cycle is essential in modulating memory processing by the hippocampal circuitry. Our combined proton magnetic resonance spectroscopy (1H‐MRS) and task‐based functional magnetic resonance imaging (fMRI) study (using face‐name paired‐associates encoding and retrieval task) of a cognitively normal cohort of 67 healthy adults (18 ApoE4 carriers and 49 non‐ApoE4 carriers) found altered patterns of relationships between glutamatergic‐modulated synaptic signalling and neuronal activity or functional hyperaemia in the ApoE4 isoforms. Our study highlighted the asymmetric left–right hippocampal glutamatergic system in modulating neuronal activities in ApoE4 carriers versus non‐carriers. Such brain differentiation might be developmental cognitive advantages or compensatory due to impaired synaptic integrity and plasticity in ApoE4 carriers. As there was no difference in myoinositol levels measured by MRS between the ApoE4 and non‐ApoE4 subgroups, the mechanism is unlikely to be a response to neuroinflammation.
Cholinergic transmission from the basal forebrain modulates social memory in male mice
Authors: Kljakic Ornela , Al‐Onaizi Mohammed , Janíčková Helena , Chen Kevin S. , Guzman Monica S. , Prado Marco A. M. , Prado Vania F. 
Published: July 2021

AbstractDisruptions in social behaviour are prevalent in many neuropsychiatric disorders such as schizophrenia, bipolar disorder and autism spectrum disorders. However, the underlying neurochemical regulation of social behaviour is still not well understood. The central cholinergic system has been proposed to contribute to the regulation of social behaviour. For instance, decreased global levels of acetylcholine release in the brain leads to decreased social interaction and an impairment of social memory in mice. Nonetheless, it has been difficult to ascertain the specific brain areas where cholinergic signalling influences social preference and social memory. In this study, we investigated the impact of different forebrain cholinergic regions on social behaviour by examining mouse lines that differ in their regional expression level of the vesicular acetylcholine transporter—the protein that regulates acetylcholine secretion. We found that when cholinergic signalling is highly disrupted in the striatum, hippocampus, cortex and amygdala mice have intact social preference but are impaired in social memory, as they cannot remember a familiar conspecific nor recognize a novel one. A similar pattern emerges when acetylcholine release is disrupted mainly in the striatum, cortex, and amygdala; however, the ability to recognize novel conspecifics is retained. In contrast, cholinergic signalling of the striatum and amygdala does not appear to significantly contribute to the modulation of social memory and social preference. Furthermore, we demonstrated that increasing global cholinergic tone does not increase social behaviours. Together, these data suggest that cholinergic transmission from the hippocampus and cortex are important for regulating social memory.
The Box Task: A novel tool to differentiate the primary progressive aphasias
Authors: Foxe David , Irish Muireann , D’Mello Mirelle , Barhon Lucienne , Burrell James R. , Kessels Roy P.C. , Piguet Olivier 
Published: July 2021

AbstractObjectiveDifferentiating the primary progressive aphasia (PPA) variants in clinical settings remains complex and challenging, especially for the logopenic (lv‐PPA) and non‐fluent variants (nfv‐PPA). Recent studies suggest that visuospatial memory is more compromised in lv‐PPA than in nfv‐PPA and is relatively spared in the semantic variant (sv‐PPA). Accordingly, assessment of visuospatial memory performance may assist in the differential diagnosis of PPA variants. Here, we investigated the utility of a novel computerised visuospatial working memory test—the Box Task—to differentiate the three PPA variants and typical Alzheimer’s disease (AD).MethodsEighteen lv‐PPA, 14 nfv‐PPA, 23 sv‐PPA, 33 AD patients, and 32 healthy controls matched for age and education were recruited. All participants completed the computerised Box Task and WMS‐III Spatial Span as measures of visuospatial working memory.ResultsThe lv‐PPA group made significantly more Box Task between‐search errors than nfv‐PPA, sv‐PPA and control groups. The AD group, however, displayed the greatest impairments on this measure relative to the PPA variants. Logistic regression analyses in lv‐PPA and nfv‐PPA demonstrated that the combination of Box Task between‐search error variables (i.e., 4‐ and 6‐box levels) could correctly classify 72% of lv‐PPA patients and nearly 79% of nfv‐PPA patients. Area under the receiver operator characteristics curve (AUC) analyses revealed the Box Task was more sensitive than Spatial Span at differentiating lv‐PPA from nfv‐PPA.ConclusionsOur findings suggest that a simple, computerised measure of visuospatial working memory—the Box Task—shows potential diagnostic utility in differentiating lv‐PPA from the other PPA variants.
Disrupted anterior and posterior hippocampal structural networks correlate impaired verbal memory and spatial memory in different subtypes of mild cognitive impairment
Authors: Du Chao , Chen Yaojing , Chen Kewei , Zhang Zhanjun 
Published: July 2021

AbstractBackground and purposeThe anterior and posterior hippocampal networks represent verbal and spatial memory, respectively, and may play different roles in the pathological mechanism of amnestic mild cognitive impairment (aMCI) and non‐amnestic MCI (naMCI), which has not been explored.MethodsA total of 990 older adults with 791 normal controls (NCs) (65 ± 6 years, 502 women), 140 aMCI (66 ± 7 years, 84 women) and 59 naMCI (66 ± 7 years, 38 women) were included. A multivariate method, partial least squares, was used to assess the structural covariance networks of the anterior hippocampus (aHC) and posterior hippocampus (pHC), and their relationships with verbal memory and spatial memory in the three groups.ResultsThree aHC and pHC structural covariance network patterns emerged: (1) the age pattern; (2) the specific aMCI pattern; and (3) the spatial memory pattern. Furthermore, aMCI patients had more extensive and severe damage in the three patterns, and correlated with greater decline in verbal memory, which was mainly characterized by the aHC network.ConclusionsThe aMCI and naMCI showed different patterns and damage in the structural covariance networks, and functional segregation of the aHC and pHC networks still exists in the process of pathological aging. A potential neural explanation is provided for the conversion of aMCI and naMCI into different types of dementia in the future.
Quality of Life in Epilepsy: Same questions, but different meaning to different people
Authors: Sajobi Tolulope T. , Josephson Colin B. , Sawatzky Richard , Wang Meng , Lawal Oluwaseyi , Patten Scott B. , Lix Lisa M. , Wiebe Samuel 
Published: July 2021

AbstractObjectivesPatient‐reported outcome measures (PROMs) are used widely to elicit patient's self‐appraisal of their health status and quality of life. One fundamental assumption when measuring PROMs is that all individuals interpret questions about their health status in a consistent manner. However, subgroups of patients with a similar health condition may respond differently to PROM questions (ie, differential item functioning [DIF]), leading to biased estimates of group differences on PROM scores. Understanding these differences can help inform the clinical interpretation of PROMs. This study examined whether DIF affects 10‐item Quality of Life in Epilepsy (QOLIE10) scores reported by patients with epilepsy in outpatient clinics.MethodsData were from the Calgary Comprehensive Epilepsy Program, a prospective registry of patients with epilepsy in Calgary, Alberta. Latent variable mixture models (LVMMs) based on standard two‐parameter graded response models with increasing numbers of latent classes were applied to QOLIE10 item data. Model fit was assessed using the Bayesian Information Criterion (BIC) and latent class model entropy. Ordinal logistic regression was used to identify QOLIE10 items that exhibited DIF.ResultsIn this cohort of 1143 patients, 567 (49.6%) were female and the median age was 37.0 (interquartile range [IQR] 27.0) years. A two‐class LVMM, which provided the best fit to the data, identified two subgroups of patients with different response patterns to QOLIE10 items, with class proportions of 0.62 and 0.38. The two subgroups differed with respect to antiseizure polytherapy, reported medication side effects, frequency of seizures, and psychiatric comorbidities. QOLIE10 items on the physical and psychological side effects of medication exhibited large DIF effects.SignificanceOur study revealed two different response patterns to quality‐of‐life instruments, suggesting heterogeneity in how patients interpret some of the questions. Researchers and users of PROMs in epilepsy need to consider the differential interpretation of items for various instruments to ensure valid understanding and comparisons of PROM scores.