bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between stroke and psychosis across four nationally representative psychiatric epidemiological studies
Authors: Bell Vaughan , Tamayo-Agudelo William , Revill Grace , Okai David , Poole Norman 
Published: November 2021

AbstractBackgroundBoth stroke and psychosis are independently associated with high levels of disability. However, psychosis in the context of stroke has been under-researched. To date, there are no general population studies on their joint prevalence and association.AimsTo estimate the joint prevalence of stroke and psychosis and their statistical association using nationally representative psychiatric epidemiology studies from two high-income countries – United Kingdom and the United States – and two middle-income countries – Chile and Colombia, and, subsequently, in a combined countries dataset.MethodsPrevalences were calculated with 95% confidence intervals. Statistical association between stroke and psychosis, and stroke and psychotic symptoms, was tested using regression models. Overall estimates were calculated using an individual participant level meta-analysis on the combined countries dataset. The analysis is available online as a computational notebook.ResultsThe overall prevalence of probable psychosis in stroke was 3.81% [95% CIs 2.34 - 5.82] and stroke in probable psychosis was at 3.15% [95% CIs 1.94 - 4.83]. The adjusted association between stroke and probable psychosis was OR = 3.32 [95% CIs 2.05 - 5.38]. On the individual symptom level, paranoia, hallucinated voices, and thought passivity delusion were associated with stroke in the unadjusted and adjusted analyses.ConclusionsRates of association between psychosis and stroke suggest there is likely a high clinical need group who are under-researched and may be poorly served by existing services.
Chronic elevation of serum S100B but not neurofilament-light due to frequent choking/strangulation during sex in young adult women
Authors: Alexander Isabella L. , Huibregtse Megan E. , Fu Tsung-Chieh , Klemsz Lillian M. , Fortenberry J. Dennis , Herbenick Debby , Kawata Keisuke 
Published: November 2021

ABSTRACTBeing choked/strangled during a partnered sex is an emerging sexual behavior, particularly prevalent among adolescent and young adult women, but the neurobiological impact of choking remains unknown. This case-control study aimed to test whether frequent choking during sex influences neurological health in young adult women, as assessed by serum levels of S100B and neurofilament-light (NfL). Participants who reported being choking ≥4 times during sex in the past 30 days were enrolled into a choking group, whereas those without were assigned to a control group. Serum samples were collected and assessed for S100B and NfL levels. Demographic questionnaires as well as alcohol use, depression, and anxiety scales were also obtained. Fifty-seven participants were enrolled initially. Due to voluntary withdrawal, phlebotomy difficulties, and scheduling conflicts, the final sample size of 32 subjects (choking n=15; control n=17) was eligible for analysis. After adjusting for a significant covariate (race), the choking group exhibited significantly elevated levels of S100B relative to controls (B=13.96 pg/mL, SE=5.41, p=0.016) but no significant group differences in NfL levels. A follow-up receiver operating characteristic analysis revealed that serum levels of S100B had very good accuracy for distinguishing between the choking and control groups [AUC=0.811, 95%CI (0.651, 0.971), p=0.0033]. Our S100B provide evidence of recurring astrocyte activation due to frequent choking while the NfL data indicate that axonal microstructural integrity may be resilient to these transient hypoxic stressors. Further clinical investigation is needed to clarify the acute and chronic neurological consequences of being choked during sex using a multimodal neurologic assessment.
Drag-and-drop genome insertion without DNA cleavage with CRISPR-directed integrases
Authors: Ioannidi Eleonora I. , Yarnall Matthew T. N. , Schmitt-Ulms Cian , Krajeski Rohan N. , Lim Justin , Villiger Lukas , Zhou Wenyuan , Jiang Kaiyi , Roberts Nathaniel , Zhang Liyang , Vakulskas Christopher A. , Walker John A. , Kadina Anastasia P. , Zepeda Adrianna E. , Holden Kevin , Gootenberg Jonathan S. , Abudayyeh Omar O. 
Published: November 2021

AbstractProgrammable and multiplexed genome integration of large, diverse DNA cargo independent of DNA repair remains an unsolved challenge of genome editing. Current gene integration approaches require double-strand breaks that evoke DNA damage responses and rely on repair pathways that are inactive in terminally differentiated cells. Furthermore, CRISPR-based approaches that bypass double stranded breaks, such as Prime editing, are limited to modification or insertion of short sequences. We present Programmable Addition via Site-specific Targeting Elements, or PASTE, which achieves efficient and versatile gene integration at diverse loci by directing insertion with a CRISPR-Cas9 nickase fused to both a reverse transcriptase and serine integrase. Without generating double stranded breaks, we demonstrate integration of sequences as large as ∼36 kb with rates between 10-50% at multiple genomic loci across three human cell lines, primary T cells, and quiescent non-dividing primary human hepatocytes. To further improve PASTE, we discover thousands of novel serine integrases and cognate attachment sites from metagenomes and engineer active orthologs for high-efficiency integration using PASTE. We apply PASTE to fluorescent tagging of proteins, integration of therapeutically relevant genes, and production and secretion of transgenes. Leveraging the orthogonality of serine integrases, we engineer PASTE for multiplexed gene integration, simultaneously integrating three different genes at three genomic loci. PASTE has editing efficiencies comparable to or better than those of homology directed repair or non-homologous end joining based integration, with activity in non-dividing cells and fewer detectable off-target events. For therapeutic applications, PASTE can be delivered as mRNA with synthetically modified guides to programmably direct insertion of DNA templates carried by AAV or adenoviral vectors. PASTE expands the capabilities of genome editing via drag-and-drop gene integration, offering a platform with wide applicability for research, cell engineering, and gene therapy.One Sentence SummaryA new technology combining CRISPR-mediated genome editing and site-specific integrases enables efficient programmable gene integration at any targeted genomic locus without double-strand DNA breaks, leading to broad applications in basic science research, cell engineering, and gene therapy.
A new analytic solution of complex Langevin differential equations
Authors: Ibrahim Rabha W. 
Published: November 2021

PurposeIn this study, the authors introduce a solvability of special type of Langevin differential equations (LDEs) in virtue of geometric function theory. The analytic solutions of the LDEs are considered by utilizing the Caratheodory functions joining the subordination concept. A class of Caratheodory functions involving special functions gives the upper bound solution.Design/methodology/approachThe methodology is based on the geometric function theory.FindingsThe authors present a new analytic function for a class of complex LDEs.Originality/valueThe authors introduced a new class of complex differential equation, presented a new technique to indicate the analytic solution and used some special functions.
Stock liquidity and stock return: an asymmetric impact of institutional ownership approach
Authors: Daryaei Abbas Ali , Fattahi Yasin 
Published: November 2021

PurposeThis study is primarily aimed at investigating the asymmetric impact of institutional ownership on the relationship between stock liquidity and stock return. It was conducted by testing the hypotheses regarding efficient monitoring and adverse selection from Tehran Stock Exchange (TSE).Design/methodology/approachUsing a panel smooth transition regression model and selecting 183 firms for the period from 2009 to 2019 from TSE, this study examined the data to explore the asymmetric impact of institutional ownership on the relationship between stock liquidity and stock return.FindingsThe results show a positive impact by institutional ownership on the relationship between stock liquidity and stock return in the first regime (threshold level 39%), whereas in the second regime, there is a negative impact by institutional ownership on the relationship between stock liquidity and stock return. Furthermore, the firms were divided into two groups based on the market value. The first group includes those with a market share less than the mean total market value of the sample. The second group includes firms with a market share higher than the mean total market value of the sample (large firms). The results illustrate that the threshold level is 32% and 44% for the first and second groups, respectively.Originality/valueThe findings of this study suggest that institutional ownership theories require closer inquiry.
Challenges of e-government implementation in health sector: a step toward validating a conceptual framework
Authors: Khan Abdul Zahid , Mahmood Faisal , Bokhari Rahat Hussain , Mushtaq Rabia , Abbas Raza 
Published: November 2021

Purpose
The importance of e-government projects has been realized in the developed as well as in the developing countries of the world. The successful implementation of e-government projects is a challenging task. Public sector organizations are facing different sorts of challenges while executing e-government initiatives. The purpose of this paper is to explore issues/challenges related to e-government project implementation.

Design/methodology/approach
A systematic literature review (SLR) was conducted to understand the challenges of the e-government project, as mentioned in past research. The findings of this SLR helped in developing a proposed framework for e-government challenges. The proposed framework encompasses challenges and issues related to four main aspects such as technological, organizational, project management and enabling environment. These aspects need to be further explained for their remedial measures. For this purpose, an exploratory case study was conducted. The unit of analysis was one of the e-government projects of the ministry of IT. The interviews of the senior and middle management involved in the implementation of this project were conducted and transcribed.

Findings
The case study findings endorse a framework proposed. The findings of this research reflect the importance of creating a shared vision, adequate funding and good project management practices as an essential aspect of e-government implementation. Further, the importance of user-related issues such as involvement, capacity building and technical skills was also found critical in successfully executing and sustaining such initiatives in the organization. Further study findings provide necessary guidance for the senior management, which may help to develop effective strategies for the e-government projects in the organization.

Originality/value
The current study focused on developing a better understanding of the challenges commonly faced by organizations during e-government adoption and implementation related to organizational, project management, enabling environment and technological aspects.
The role of entrepreneurial resilience in forms of collaboration: a systematic literature review with bibliometric analyses
Authors: Candeias Fernandes Ana Joana , Franco Mário 
Published: November 2021

PurposeFocused on the intersection between entrepreneurial resilience and different forms of collaboration, this research makes a systematic analysis of the literature resorting to various complementary bibliometric techniques (keyword co-occurrence; bibliographic coupling of documents; bibliographic coupling of authors; co-citation of references).Design/methodology/approachAccording to the research protocol defined, a search by topics was made in Web of Science (WoS), with no time restriction, which led to including 97 articles in the sample. Descriptive analysis identified the evolution and tendency of publications and citations, the most productive journals, universities and countries in this topic and the research methodologies followed in the articles of the sample.FindingsThe different bibliometric techniques applied led to understanding and systematization of the tendencies and themes concerning the topic, allowing the development of a conceptual framework articulating them and revealing possible lines of research that could contribute to developing the literature.Practical implicationsBy showing different facets of the intersection between entrepreneurial resilience and collaboration, this paper highlights the multiple implications of this area at different levels of analysis (individuals, ventures and communities) with the importance of networks of collaboration patent in each. Therefore, this study can help entrepreneurs, business and political decision-makers to make better informed decisions, which can be particularly relevant in scenarios of uncertainty and crisis, such as the present, arising from the global pandemic.Originality/valueAs far as the authors know, the research carried out is the first centred on systematic analysis of entrepreneurial resilience and forms of collaboration. It gives a complete conceptual and theoretical picture of the evolution of research on the topic and accordingly points out possible avenues for future research.
The drivers and effects of burnout within an information technology work context: a job demands-resources framework
Authors: Zaza Sam , Riemenschneider Cynthia , Armstrong Deborah J. 
Published: November 2021

PurposeThe purpose of this empirical study is to explore the drivers and effects of a multidimensional conceptualization of burnout for information technology (IT) personnel using the job demands-resources framework.Design/methodology/approachUsing survey data from 247 IT professionals, the authors analyzed our model using partial least squares structural equation modeling (PLS-SEM), a composite-based method.FindingsThe authors find that job demands and job resources differently influence the dimensions of burnout, and the burnout dimensions influenced turnover intention (leave the organization) and turnaway intention (leave the field) except for cynicism, which did not affect turnover intention. The authors’ findings suggest that managers and human resource professionals may want to look beyond managing work exhaustion and consider focusing on the professional efficacy dimension of burnout to keep their IT professionals from leaving the organization and the IT industry.Originality/valueThis study highlights the need for researchers in the information systems field to rethink using exhaustion as a proxy for the burnout construct as focusing on work exhaustion does not tell the full story for IT professionals. Additionally, the findings indicate that job-related burnout affects not only IT professional's turnover intention but also turnaway intention. Last, psychosocial mentoring did not directly influence any of the burnout components but indirectly influenced all three components.
Moving beyond traditional sponsorships: understanding the structure and dynamics of minority equity sponsorship agreements
Authors: Gur Furkan Amil , Bouchet Adrien , Walkup Brian R. , Jensen Jonathan A. 
Published: November 2021

PurposeThe purpose of this study is to understand the structure and dynamics of minority equity sponsorship agreements and the motivations for organizations to go beyond traditional sponsorships by acquiring minority equity in the sponsored organization.Design/methodology/approachThis paper adopts a qualitative methodology and presents interview data from key actors involved in minority equity sponsorship agreements.FindingsThe findings of the paper include major characteristics of minority equity sponsorship agreements including the motivations, dynamics and resources exchanged by sponsoring firms and clubs in these relationships, based on the experiences of key actors from firms, clubs and other key stakeholders, and a conceptual model for forming and maintaining these relationships.Practical implicationsSponsorships are increasingly evolving into minority equity sponsorship agreements, particularly in the European market. The findings of this study assist sponsoring firms and the executives of clubs in better understanding the dynamics and stakeholder-related consequences of these relations.Originality/valueThe findings of this paper illustrate the differences between minority equity sponsorship agreements and both traditional sponsorships and minority equity alliances. The findings also identify major characteristics of these relationships and the interdependencies among these characteristics.
Analysis of drivers for anti-food waste behaviour - TISM and MICMAC approach
Authors: Poonia Archana , Sindhu Shilpa , Arya Vikas , Panghal Anupama 
Published: November 2021

Purpose
This study aims to identify and analyse the interactions among drivers of anti-food waste behaviour at the consumer level. By understanding the mutual interactions among the drivers, an effort is made to identify the most driving and most dependent drivers through the total interpretive structural modelling (TISM) approach. Modelling offers inputs to propose focused interventions for reinforcing the identified drivers of anti-food waste consumer behaviour using the theoretical lens of social practices theory.

Design/methodology/approach
A proposed model of factors affecting anti-food waste behaviour is arrived at to suggest the most effective anti-food waste behavioural interventions. The factors were identified through an extensive literature search. A hierarchical structure of identified factors has been developed using TISM and MICMAC analysis through expert opinion. Focused marketing strategies towards promoting the identified factors for encouraging anti-food waste behaviour were suggested further.

Findings
This study identifies nine drivers based on extensive literature review, brainstorming and expert opinion. The TISM hierarchical model portrays the most important and least important drivers of household anti-food waste behaviour. It establishes that fundamental knowledge and socio-cultural norms are the most critical factors to drive the consumers. Marketers can focus on designing effective interventions to enhance the essential knowledge of the consumers and orient the socio-cultural norms towards anti-food waste behaviour.

Practical implications
This study offers implications for practitioners, policymakers and cause-driven marketing campaigns targeting anti-food waste behaviour. It provides an indicative list of critical factors relevant to household food waste behaviour, which can be used to drive effective marketing campaigns to nudge anti-food waste behaviours.

Originality/value
The proposed food waste behaviour management model was developed through modelling technique (TISM) and Cross-Impact Matrix Multiplication Applied to Classification (MICMAC) analysis, and relating them to marketing interventions is a novel effort in the food waste domain.
Importance of telephone follow-up and combined home visit and telephone follow-up interventions in reducing acute healthcare utilization
Authors: Lee Yuan Ying , Tiew Lay Hwa , Tay Yee Kian , Wong John Chee Meng 
Published: November 2021

PurposeTransitional care is increasingly important in reducing readmission rates and length of stay (LOS). Singapore is focusing on transitional care to address the evolving care needs of a multi-morbid ageing population. This study aims to investigate the impact of transitional care programs (TCPs) on acute healthcare utilization.Design/methodology/approachA retrospective, longitudinal, interventional study was conducted. High-risk patients were enrolled into a transitional care program of local tertiary hospital. Patients received either telephone follow-up (TFU) or home-based intervention (HBI) with TFU. Readmission rates and LOS were assessed for both groups.FindingsThere was no statistically significant difference in readmissions or LOS between TFU and HBI. After excluding demised patients, TFU had statistically significant lower LOS than HBI. Both interventions demonstrated statistically significant reductions in readmissions and LOS in pre–post analyses.Research limitations/implicationsTFU may be more effective than HBI in patients with lower clinical severity, despite both interventions showing statistically significant reductions in acute healthcare utilization. Study findings may be used to inform transitional care practices. Future studies should continue to examine the comparative effectiveness of transitional care interventions and the patient populations most likely to benefit.Originality/valuePrevious studies demonstrated promising outcomes for TFU and HBIs, but few have evaluated their comparative effectiveness on acute healthcare utilization and specific patient populations most likely to benefit. This study evaluated interventional effectiveness of both, which might be useful for informing allocation of resources based on clinical complexity and care needs.
Thinking, checking and learning: testing a moderated-mediation model of social media news use conditional upon elaboration on political knowledge via fact-checking
Authors: Kim Bumsoo , Cooks Eric , Kim Yonghwan 
Published: November 2021

PurposeEmploying the cognitive mediation model, the study aims to examine a moderated-mediation mechanism of social media news use contingent upon elaboration on political knowledge through fact-checking – specifically, the interaction effect of social media news with elaboration on fact-checking.Design/methodology/approachThe moderated-mediation model is tested using panel survey data collected during the 2016 USA presidential election (N = 1,624 at Wave 1; N = 637 at Wave 2).FindingsThe findings reveal that social media news users are frequent visitors of fact-checking websites. Results also suggest that those with increased social media news use and cognitive elaboration on news content are more likely to visit fact-checking sites, which contributes to increased political knowledge.Originality/valueThe results of the current study, especially in the era of social media environment where various information is overflowing, suggest an important role of individuals' responsibility as democratic citizens given that people's cognitive elaboration and surveillance efforts, which tries to think about important public issues they consume through media, could strengthen a positive pathway toward informed citizens.