bluuebunny/crossref_metadata_2025_split huggingface dataset:
De l’image narrative à l’image narratrice. Ce que la théorie de Genette fait dire sur Mélusine
Authors: Pérez-Simon Maud 
Published: July 2021

Il est d’usage de parler de narrativité d’une image, dès qu’elle transpose un récit, ou qu’elle comporte des éléments de temporalité. Cet article propose d’élargir la zone de compétence et les prérogatives de l’image : l’image ne serait pas seulement « narrative » mais « narratrice ». Elle est en effet capable de prendre en charge toutes les fonctions du narrateur telles que Genette les décrit dans Figures III. Cette proposition théorique est démontrée par le biais d’un manuscrit de Mélusine de Coudrette (BnF fr. 24383). L’image peut endosser les cinq fonctions du narrateur selon Genette ; six en réalité, car nous faisons le constat de la nécessaire dissociation des fonctions explicatives et idéologiques. Les miniatures ne font pas que « raconter » une histoire (fonction narrative), elles participent à l’organisation du récit et de la temporalité des événement (fonction de régie), établissent un lien avec le lecteur (fonction de communication), fournissent des explications (fonction explicative), soutiennent le propos idéologique du texte (fonction idéologique), transmettent une émotion (fonction testimoniale). Cette réflexion permet de rendre compte du rôle des images dans l’agencement du texte au sein du manuscrit et d’inverser le rôle de subordination texte-image, tout en ouvrant des perspectives sur la fonction narratrice des images dans d’autres media.
Prunelle Deleville, Métamorphose des Métamorphoses, édition critique et étude littéraire des manuscrits Z de l’Ovide moralisé
Authors: Deleville Prunelle 
Published: July 2021

Parmi les copies tardives de l’Ovide moralisé, un groupe spécifique, appelé Z, fournit une véritable réécriture de l’œuvre initiale. Il est formé des codices : Berne, Burgerbibliothek, 10 (Z1) écrit après 1456 ; Paris, BnF, français 874 (Z2) copié en 1456 ; Paris, BnF, français 870 (Z3) composé autour de 1400 pour le texte et 1450 pour le décor ; Paris, BnF, français 19121 (Z4) probablement réalisé entre 1390 et 1410. Le remanieur modifie le récit de la fable, ajoute des expositions historiques inédites dans la tradition de l’Ovide moralisé. Telles sont les modifications communes que présentent les copies Z. Cependant, des divergences se manifestent dans cette famille. Les témoins Z3 et Z4 sont dépourvus d’allégories religieuses, alors que ces dernières ont été réintroduites dans Z1 et Z2. Ces quatre manuscrits présentent donc un moment riche dans la vie de l’Ovide moralisé. L’édition de ce texte, selon le manuscrit Z3, rend compte des spécificités linguistiques de cette reprise de l’Ovide moralisé un siècle après sa création, mais aussi des aspects littéraires de cette réécriture. Le remaniement Z, qui correspond au texte du sous-ensemble Z34, est cohérent et réfléchi. Les traces du dogme chrétien sont minutieusement effacées. L’esthétique du texte converge avec celle des mises en proses, qui se multiplient à partir de la fin du xive siècle mais surtout avec les débats littéraires de l’époque, comme celui autour du Roman de la Rose. Le réviseur exprime aussi le fait que son rejet des allégories repose sur une adéquation plus stricte avec Ovide, qui ne pouvait pas concevoir d’interprétations christianisantes de son propre texte.
Lutte contre l’inflation : enjeux de la fixation des salaires à Électricité de France
Authors: Bénistand Hélène 
Published: July 2021

En 1946, la création d’EDF s’inscrit dans la lignée du programme du Conseil national de la Résistance et vise à assurer la souveraineté nationale en créant des « champions nationaux ». Dans le cadre de sa politique de lutte contre l’inflation, l’État s’emploie à contrôler les salaires dans tous les domaines. Cela revient à imposer aux entreprises comme EDF des objectifs dépassant leurs enjeux propres. Dans les industries de flux, comme EDF, la fixation des salaires soulève des problématiques particulières. Le maintien du flux productif repose sur le fonctionnement continu des installations. Dans le cadre d’un travail de « surveillance-contrôle », les travailleurs mobilisent leurs compétences dans des situations parfois imprévisibles. Cela semble appuyer l’idée que ces derniers méritent un salaire plus élevé que la moyenne et un statut social protecteur, dont le but est en partie d’« acheter » la paix sociale. Or, cette logique se heurte à la volonté de la tutelle de maîtriser les salaires du secteur public du fait de leur effet d’entraînement supposé sur le secteur privé. L’entreprise EDF, sous la direction d’André Decelle, tente alors de lier l’évolution des salaires à la productivité en développant des calculs de productivité globale, pour prouver la légitimité des hausses de salaire. Ces luttes autour des salaires amènent plus globalement à poser la question du statut d’une entreprise publique : est-elle maîtresse de sa gestion ou est-elle nécessairement un outil, soumis aux enjeux économiques nationaux ? Cet article vise à montrer que la question des salaires cristallise la tension entre les objectifs politiques poursuivis par l’État et la gestion rationnelle de l’entreprise, portée par les ingénieurs-économistes dirigeants de l’entreprise.
Antioxidant and antigenotoxic properties of Alpinia galanga, Curcuma amada, and Curcuma caesia
Authors: Nag Anish , Banerjee Ritesh , Goswami Priya , Bandyopadhyay Maumita , Mukherjee Anita 
Published: July 2021

Objective:
To compare the antioxidant and anti-genotoxic properties of Alpinia (A.) galanga, Curcuma (C.) amada, and C. caesia.

Methods:
Cytotoxicity of ethanolic extracts of A. galanga, C. amada, and C. caesia at selected doses was evaluated by trypan blue, MTT, and flow cytometry-based assays. Genotoxicity and anti-genotoxicity (against methyl methanesulfonate, 35 μM and H2O2, 250 μM) of these plants were studied by comet assay in human lymphocytes in vitro. Furthermore, DPPH, ABTS, FRAP, lipid peroxidation, and hydroxyl radical scavenging assays were performed to study the antioxidant potentials of the plants. Finally, anti-genotoxic potential of C. amada was validated in Swiss albino mice using comet assay. Phytochemical composition of C. amada was determined by GC/MS and HPLC.

Results:
The selected doses (2.5, 5, and 10 μg/mL) of A. galanga, C. amada, and C. caesia were non-toxic by cytotoxicity tests. All three ethanolic extracts of plant rhizomes demonstrated antioxidant and anti-genotoxic properties against methyl methanesulfonate-and H2O2-induced oxidative stress in human peripheral blood lymphocytes in vitro. Multivariate analysis revealed that various antioxidant properties of these extracts in DPPH, ABTS, and FRAP assays were strongly correlated with their total phenolic constituents. C. amada extract conferred protection against cyclophosphamide-induced DNA damage in the bone marrow cells of mice and DNA damage was significantly inhibited by 2.5 mg/kg C. amada extract.

Conclusions:

C. amada is rich in potentially bioactive molecules and exhibits potent antioxidant activities. Its anti-genotoxicity against cyclophosphamide-induced oxidative stress is also confirmed in this study.
Clinico-Radiological Progression in COVID-19 Patients
Authors: Dholakia Akash G. , Patel Monila N. , Dave Ruchir B. , Shah Dharita S. , Poddar Shivam O. , Trada Parita K. 
Published: July 2021

Background:
Coronavirus disease 19 (COVID-19) caused by a severe acute respiratory syndrome coronavirus-2 belonging to the Coronaviridae family has caused a global pandemic. As it has emerged as a newer disease, there is a lack of information in many aspects of it. Materials
and

Methods:
We tried to study the progression in the COVID-19 patients in terms of their clinical, laboratory, and X-rays as a radiological modality, for that, we did a single-centered retrospective observational study in 159 laboratory-confirmed COVID-19 positive patients with sample size being duration dependent.

Results:
We found statistically significant correlation between clinical parameters and lung involvement based on chest X-ray (CXR) scoring and also temporal variation as the disease progression occurs.

Conclusion:
Along with clinical and laboratory parameters, CXRs can be used as a useful bedside, inexpensive, and easily available radiological tool for assessment in resource-poor settings where high-resolution computed tomography scans are not feasible.
Anlotinib followed by transarterial chemoembolization and radiofrequency ablation is a safe and effective initial treatment for hepatocellular carcinoma patients with portal vein tumor thrombus
Authors: Wang Jianpeng , Li Xishan , Wang Fengjie , Shi Degang , Zhang Jiren 
Published: July 2021

Background:
Portal vein tumor thrombus (PVTT) remains a poor prognostic factor occurring in about 10%–40% of patients with hepatocellular carcinoma (HCC) for the optimal treatment is controversial. Anlotinib is an novel small molecule inhibitor that has a broad spectrum of inhibitory activities on tumor angiogenesis and growth. However, so far, no studies have reported the use of anlotinib in the treatment of HCC patients with PVTT. Here, we evaluated the safety and efficacy of anlotinib, followed by transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) for the treatment of patients with HCC and PVTT.

Materials and Methods:
A total of 145 consecutive HCC patients who underwent TACE in combination with RFA were enrolled in the retrospective study. Twenty-eight patients were diagnosed with PVTT and received anlotinib as basic treatment. The adverse events (AEs) were graded according to the National Cancer Institute Common Terminology Criteria for AEs Version 4.0. Time to tumor progression (TTP) and overall survival (OS) were calculated using the Kaplan–Meier method.

Results:
The most common toxicities related to anlotinib were pharyngalgia (53.6%), fatigue (42.9%), and hand–foot skin reaction (39.3%). The median OS was 13 months (range: 3–18 months) with 1-year OS rate of 64.3%. The median TTP was 7 months (range: 1–12 months) with 6-month rate of 46.4%.

Conclusion:
Anlotinib followed by TACE and RFA is a safe and effective initial treatment modality for HCC patients with PVTT. Anlotinib may be a promising therapeutic option for relieving and/or stabilizing HCC with PVTT.
Computed tomography-guided lung biopsy
Authors: Zhang Ping , Liu Jing-Mei , Zhang Ying-Ying , Hua Rong , Xia Feng-Fei , Shi Yi-Bing 
Published: July 2021

Objectives:
The aim of the study was to compare the relative diagnostic utility of low-dose computed tomography (LDCT) and standard-dose computed tomography (SDCT)-guided lung biopsy approaches.

Materials and Methods:
The PubMed, Embase, and Cochrane Library databases were searched for relevant studies published through August 2020. Data pertaining to endpoints including technical success, diagnostic performance, operative time, radiation dose, and complications, were extracted, and meta-analysis was performed using RevMan v5.3.

Results:
Three retrospective analyses and three randomized controlled trials, were included. The studies included 1977 lung lesions across 1927 patients who underwent LDCT-guided lung biopsy, and 887 lung lesions across 879 patients who underwent SDCT-guided lung biopsy. No significant differences were observed between these LDCT and SDCT groups with respect to the rates of technical success (99.0% vs. 99.5%, odds ratio [OR]: 1.82, P = 0.35,), diagnostic yield (79.6% vs. 76.2%, OR: 0.93, P = 0.47), diagnostic accuracy (96.1% vs. 96.1%, OR: 0.93, P = 0.69), operative time (mean difference [MD]: 1.04, P = 0.30), pneumothorax (19.9% vs. 21.3%, OR: 0.92, P = 0.43) or hemoptysis (4.6% vs. 5.8%, OR: 1.14, P = 0.54). Patients in the LDCT group received a significantly lower radiation dose (MD: [FIGURE DASH]209.87, P < 0.00001) than patients in the SDCT group. Significant heterogeneity was observed with respect to the operative duration and radiation dose endpoints (I2= 84% and 100%, respectively).

Conclusions:
Relative to SDCT-guided lung biopsy, an LDCT-guided approach is equally safe and can achieve comparable diagnostic efficacy while exposing patients to lower doses of radiation.
Changes in thyroid antibody and T lymphocyte subsets after radiofrequency ablation of thyroid nodules in patients with autoimmune thyroiditis
Authors: Tang Xiaoyin , Li Ping , Zhai Bo , Zhu Xiaoli 
Published: July 2021

Settings and Design:
The aim was to study the changes in thyroid antibody and T lymphocyte subsets after radiofrequency ablation (RFA) of thyroid nodules in patients with autoimmune thyroiditis.

Subjects and Methods:
Patients (n = 135) with autoimmune thyroiditis and thyroid nodules were treated by RFA. The indices of thyroid function and thyroid antibody and T lymphocyte subsets were examined preoperation and on the 1st day and the 1st month after ablation. Any complications were recorded.

Statistical Analysis:
The software SPSS 17.0.0 (version: 2008-8-23) running under Windows 8 was used for statistical analysis. The measurement data were expressed as x ± s, with P < 0.01 indicating a significant difference in the statistical data.

Results:
Levels of free triiodothyronine, free thyroxine, and thyroid-stimulating hormone were in the normal range before ablation, and no significant changes occurred on the 1st day or in the 1st month after ablation. The change in the percentage of CD8+T cells and the absolute value of B cells were not statistically significant (P > 0.01), and the values were in the normal range. Compared with values recorded preoperation, the value of TG-Ab, TPO-Ab, CD4+/CD8+, the percentage of CD4+T cells, the absolute values of lymphocytes, T cells, CD4+T cells, and CD8+T cells decreased significantly at the 1st day after ablation (P < 0.01) and then recovered to preoperative levels during the first 30 days after ablation (P > 0.01). Within 1 month after ablation, none of the patients had complications such as active bleeding, infection, recurrent laryngeal nerve injury, parathyroid gland injury, skin scald, and so on.

Conclusions:
After RFA of thyroid nodules in patients with autoimmune thyroiditis, thyroid function is not affected and no serious complications occurred. TG-Ab and TPO-Ab levels can be significantly decreased, and the distribution of T lymphocyte subsets can be changed in the short term after ablation.
Comparative analysis of bile culture and blood culture in patients with malignant biliary obstruction complicated with biliary infection
Authors: Wang Chengli , Yu Haipeng , He Ji'an , Li Mei , Zhang Lei , Xu Yan , Gao Wei , Yang Xueling , Guo Xiuying , Guo Zhi 
Published: July 2021

Objective:
This study is aimed to provide a clinical basis for the identification and treatment of patients with malignant biliary obstruction (MBO) complicated with biliary infection by comparing pathogenic bacteria detected in bile and blood cultures from these patients.

Materials and Methods:
A total of 380 patients with MBO who received percutaneous transhepatic cholangic drainage from January 2004 to January 2019 were included in the study. A total of 90 patients were diagnosed with having MBO complicated with biliary infection, and bile and blood culture were simultaneously performed on these patients. The patients included 58 men and 32 women, ranging in age from 33 to 86 years old, with a mean age of 60.69 years.

Results:
The detection rate using bile bacterial culture in patients with MBO complicated with biliary infection was significantly higher than that using blood culture, and there were significant differences in the two kinds of bacterial culture found positive bile and blood cultures from the same patients. Gram-positive cocci were dominant in the bile cultures and Gram-negative bacilli were dominant in the blood cultures. Therefore, it is necessary to conduct simultaneous bile bacterial culture and blood culture for patients with MBO complicated with biliary infection, especially those with severe or critical diseases.

Conclusions:
It is vital to enable simultaneous bile bacterial culture and blood culture in patients with MBO complicated with biliary infection. Existing guidelines for the diagnosis and treatment of benign biliary infection are not applicable to patients with MBO complicated with biliary infection.
Short-term efficacy and safety of callispheres drug-loaded microsphere embolization in primary hepatocellular carcinoma
Authors: Li Jinpeng , Wang Nan , Shi Congcong , Liu Qingran , Song Jinlong , Ye Xin 
Published: July 2021

Background:
Drug-eluting beads transarterial chemoembolization (DEB-TACE) is a newly developed local regional therapy for improving the efficacy and safety of conventional transarterial chemoembolization (cTACE), which is now universally used to treat patients with unresectable liver cancer.Cohort studies, clinical trials, and meta-analysis have shown DEB-TACE to be associated with favorable treatment responses, prolonged survival, and at least similar safety profile when compared with cTACE.

Aims and Objectives:
This study was to evaluate the short term clinical efficacy, side effects, and risk factors affecting the clinical effectiveness of CalliSpheres drug loaded bead transcatheter arterial chemoembolization (DEB TACE) in the treatment of primary hepatocellular carcinoma (HCC).

Materials and Methods:
A total of 172 consecutive patients with HCC undergoing DEB TACE (loaded with doxorubicin) from January 2017 to December 2018 were prospectively enrolled. Short term local tumor response was evaluated by the modified RECIST criteria. Postoperative complications and liver function disorders were analyzed based on examinations and clinical symptoms.

Results:
The median follow up period was 310 days. Based on the modified response evaluation criteria in solid tumors criteria, objective response rates(complete response [CR] + partial response [PR]) were 78.7%, 71.6%, and 63.2%, and disease control rates(CR + PR + stable disease) were 95.3%, 92.1%, and 85.9% at 2, 4, and 6 months posttreatment, respectively. Multivariate logistic regression analysis showed that nodule number >3, high BCLC stage, no vascular leak, and previous conventional TACE treatment were associated with poor ORR (P < 0.05). Postoperation, liver function showed transient changes. Postoperative complications were tolerated and relieved by symptomatic treatment. The average interval of TACE before D TACE was 43 days, compared with 70 days for average interval of DEB TACE. The average hospital stay was 1.87 days.

Conclusion:
DEB TACE has improved short term efficacy and lower incidence of complications in primary HCC and prolongs the interval of TACE. It significantly increases the ORR, especially in patients with no extra hepatic metastasis pretreatment. DEB usage actually improves treatment efficacy and provides more benefits to patients. KEY WORDS: Drug-loaded bead-transcatheter arterial chemoembolization, hepatocellular carcinoma, microsphere embolization
Ultrasound-guided percutaneous microwave ablation for hepatocellular carcinoma originating in the caudate lobe
Authors: Peng Yuan , Cui Dan , Li Weijian , Ding Ming , Shi Yaoping , Wang Tao , Shi Donghua , Chi Jiachang , Li Ping , Zhai Bo 
Published: July 2021

Objective:
This study aimed to evaluate the efficacy, feasibility, and tolerability of ultrasound (US)-guided percutaneous microwave ablation (MWA) for treating hepatocellular carcinoma (HCC) originating in the caudate lobe.

Materials and Methods:
The treatment and survival parameters of 32 patients with HCC in the caudate lobe, who met the inclusion criteria and had received US-guided percutaneous MWA in our department from November 2010 to October 2015, were retrospectively analyzed. Imaging examination (contrast-enhanced computed tomography or magnetic resonance) 1 month after MWA was used to evaluate the efficacy of US-guided MWA.

Results:
Thirty-two patients underwent percutaneous MWA for caudate lobe HCC. The average tumor size was 3.42 ± 0.27 (range: 1–6.8) cm. The initial complete ablation (CA) rate was 87.5% (28/32), and the total CA rate was 96.88% (31/32). Furthermore, the median length of hospitalization was 4 days (range: 2–10 days), and no major complication was observed in this study. The overall survival rates were 87.5%, 50%, and 28.13% at 1, 2, and 3 years, respectively. The progression-free survival after MWA was 93.75%, 53.15%, and 28.13% at 6, 12, and 18 months, respectively.

Conclusions:
US-guided percutaneous MWA was a safe and effective treatment. It is a promising alternative therapy for HCC originating in the caudate lobe.
Multiregion sequencing and subclonal analysis reveal intratumoral heterogeneity in esophageal squamous cell carcinoma
Authors: Gao Dongni , Zhang Zicheng , Yang Qiwei , Li Baosheng 
Published: July 2021

Purpose:
The aim of this study was to investigate intratumoral genomic heterogeneity and subclonal structure of esophageal squamous cell carcinoma (ESCC).

Materials and Methods:
Multiregion whole-exome sequencing was performed on 24 surgically acquired tumor samples from five untreated ESCC patients collected in 2019 to determine the heterogeneity of mutational landscape within tumors. Phylogenetic analysis and mutation process analysis were used to explore the distribution and dynamic changes of mutation spectrum, and subclone analysis was used to explore the subclonal composition and spatial structure of ESCC.

Results:
An average of 60.2% of mutations were found heterogenous. TP53 and NOTCH1 mutations were confirmed to be early events, and mutations unique in different tumor regions showed a pattern of branching evolution. A large proportion of mutations were associated with abnormal activity of the apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) family, and significant differences in mutation types between trunk and branch variants were found. Subclonal structure exhibited spatial correspondence and spatial limitations, and different genomic features were characterized between close and distant clones.

Conclusions:
There is significant intratumoral genomic heterogeneity in the five ESCCs, and their subclonal structure is related to spatial locations.
The clinical efficacy of computed tomography-guided125I particle implantation combined with arterial infusion chemotherapy in the treatment of pancreatic cancer
Authors: Yang Liang , Li Chuang , Wang Zhe , Wu Jinyu , Zhou Jun , Wang Ruoyu 
Published: July 2021

Aims:
This study aimed to investigate the clinical value of 125I radioactive particle implantation combined with regional arterial chemotherapy perfusion in the treatment of pancreatic cancer.

Subjects and Methods:
The clinical data of 23 patients with pancreatic cancer were retrospectively analyzed, and the patients were divided into two groups. In the observation group, 11 patients were injected with radioactive particles in combination with regional arterial chemotherapy. In the control group, 12 patients were treated with simple regional arterial perfusion chemotherapy. Curative effect, pain relief, survival period, and adverse reactions were compared between the two groups.

Results:
The proportion of patients was significantly higher in the observation group (complete remission + partial remission) (72.73%) than in the control group (41.67%). The 6-month and 9-month survival rates in the experimental group were 91.7% and 50%, respectively, while those in the control group were 63.6% and 18.2%, respectively, with significantly statistical difference. The 12-month survival rate in the experimental group was 16.7% and was significantly higher than that in the control group (8.3%). The experimental group should greater improvement in pain symptoms than the control group, and there was no statistical difference between the two groups except in complications of 125I radioactive particle implantation.

Conclusions:
We conclude that 125I radioactive particle implantation combined with regional arterial perfusion chemotherapy is an effective and comprehensive treatment for advanced pancreatic cancer.