bluuebunny/crossref_metadata_2025_split huggingface dataset:
Astragaloside IV attenuated TGF-β1- induced epithelial-mesenchymal transition of renal tubular epithelial cells via connexin43 and Akt/mTOR signaling pathway
Authors: Lian Yonghong , Li Cuiqiong , Li Jianchun , Xie Yongxiang , Liu Qiancheng , Wu Minhua , Shi Wei , Meng Lifeng 
Published: November 2021

Abstract
INTRODUCTION: The objective of the study was to observe whether Cx43 could regulate EMT of RTECs by influencing Akt/mTOR signaling pathway, and whether ASV could inhibit the development of renal interstitial fibrosis by regulating Cx43. METHODS: Lentivirus infection was transfected into RTECs with the final concentration of 50×PFU/ cell to regulate the expression of Cx43.And RTECs were intervened by different doses of ASV. After synchronous culture of RTECs in each group,cell morphological changes were observed and the expression levels of EMT-related indicators, and the expression levels of Cx43, the protein expressions and phosphorylation levels AKT and mTOR in different groups were detected by WB. RESULTS: When the expression of Cx43 in RTECs was regulated by lentivirus infection, the degree of EMT induced by TGF‑β1 and the phosphorylation level of Akt and mTOR were changed accordingly, indicating that Akt/mTOR pathway might be a downstream molecular mechanism by which Cx43 could regulate EMT. After intervention with different doses of ASV, the expression level of Cx43 increased with obvious concentration dependence, and the expression levels of p-Akt and p- mTOR were significantly altered, suggesting that ASV could effectively increase the protein expressions of TGF‑β1-induced Cx43 in RTECs and inhibit the phosphorylation levels of Akt and mTOR. CONCLUSION: Cx43 is the main material basis of RTECs’injury, and ASV could inhibit TGF-β1 induced RTECs transdifferentiation. In-depth study of the mechanism may provide a broad application prospect for the treatment of renal interstitial fibrosis.
Seismic Assessment and Rehabilitation of a RC Structure Under Mainshock-Aftershock Seismic Sequences Using Beam-Column Bonded CFRP Strategy
Authors: Soureshjani Omid Karimzade , Nouri Gholamreza 
Published: November 2021

Abstract
A mainshock is usually accompanied by a group of ground motions. In many design codes, the effects of the seismic sequences have been neglected or underestimated. Aftershocks can increase structural damage or even cause failure. The current study evaluated the seismic behavior of a rehabilitated and as-built RC structure under real scaled mainshock-aftershocks using nonlinear analysis. Verification was done in two modes. The inter-story drift ratio, maximum residual, and relative displacements were studied. The seismic study of the as-built structure showed that the residual displacement grew, on average, more than 90% under the mainshock-aftershock sequence compared to the mainshock-only record. A beam-column bonded CFRP rehabilitation strategy using six layers of T-700 CFRP was chosen based on the specific performance level. The strategy showed the ability to transfer the plastic strain from the columns to the beams, which could be considered as a change from a weak column-strong beam concept to a strong column-weak beam concept. Compared to the as-built structure under the seismic sequences, the rehabilitated structure showed an average growth of 78% in the first-story drift ratio, which was significant. Unlike the as-built structure, seismic sequences caused no growth drift in the rehabilitated structure. It also was observed that the ratio of aftershock PGA to mainshock PGA could have an intensive effect on the seismic behavior of both rehabilitated and as-built structures.
Weak or No Correlation Between Recent COVID-19 Data and Vaccination Rates in France
Authors: Bouanane Mohamed 
Published: November 2021

Abstract
Since August 9, the "health pass" became mandatory in France and applies to many economic sectors and social activities such as commercial catering, trade fairs and exhibitions, healthcare services and medical-social centres, public long-distance transport, and some stores and shopping malls. In addition, since September 30, 2021, the "health pass" has been made compulsory for minors aged 12 and two months to 17 years old. The aim is to better control the spread of the Sars-Cov-2 virus by forcing the entire population to be vaccinated in order to reduce the effects of the epidemic. Since vaccination is currently the only pursued strategy to fight against COVID-19 in the world, we were interested in verifying the explanation often put forward to justify the improvement (due to high vaccination rate) or the recrudescence (due to low vaccination percentage) of the health situation linked to COVID-19. At the same time, several developed countries have launched the injection of a third dose of vaccines following a substantial increase in COVID-19 cases. In this regard, we have studied the correlation between the levels of vaccination coverage (percentage of the vaccinated population) and the various epidemiological variables of COVID-19 in the 101 French departments (territories) during the month of September 2021. The findings of the study indicate no significant relationship between vaccination rates and COVID-19 data.
Unilateral Thalamic Infarction Associated with Rupture of Dissecting Posterior Cerebral Artery in Childhood-Onset Systemic Lupus Erythematosus: A Case Report
Authors: Kim Hye Jin , Kang Seongryeong , Kim Young Rak , Kim Kyung Hyun , Choi Yun Jung , Lee Soyoung 
Published: November 2021

Abstract
BackgroundCerebrovascular diseases are well-known complications of systemic lupus erythematosus (SLE). Among them, cerebral arterial dissection is a rare vascular complication, in which an intimal tear of the blood vessel leads to an intramural hematoma. Cerebral arterial dissection leads to arterial stenosis, thrombosis, and aneurysm, resulting in cerebral infarction or subarachnoid hemorrhage (SAH). Herein, we report a case of posterior cerebral artery (PCA) dissection in SLE that presented as unilateral thalamic infarction followed by SAH and intraventricular hemorrhage (IVH). Case PresentationA 16-year-old boy hospitalized with prolonged fever, hair loss, and skin eruption was newly diagnosed with SLE based on the 2019 EULAR/ACR SLE classification criteria. He suddenly complained of headache, diplopia, and impairment of lateral gaze during hospitalization. Brain magnetic resonance imaging revealed left thalamic infarction, although cerebral vessel inflammation or thrombosis was not observed. Antiphospholipid antibodies such as lupus anticoagulant, anti-cardiolipin antibody, and anti-β2-glycoprotein antibody were not detected. His symptoms improved with high-dose steroid, low-dose aspirin, and mannitol therapy. Five days later, he experienced severe headache and generalized tonic-clonic seizures. Brain computed tomography revealed SAH and IVH with hydrocephalus. Even though emergent external ventricular drainage was performed, the ventricle size did not decrease. Transfemoral cerebral angiography revealed a ruptured dissecting PCA pseudoaneurysm, and immediate coil embolization was successfully performed. The patient fully recovered without any neurologic sequelae, although he underwent ventriculoperitoneal shunting for hydrocephalus following SAH. ConclusionsTo the best of our knowledge, this is the first reported case of PCA dissection in a patient with childhood-onset SLE. Moreover, the subsequent progression from cerebral infarction to SAH caused by PCA dissection makes this case unique. In SLE patients presenting with cerebral infarction and hemorrhage, cerebral arterial dissection and pseudoaneurysm should be considered to achieve favorable outcomes.
Transfer Printing of Perovskite Whispering Gallery Mode Laser Cavities by Thermal Release Tape
Authors: Li Guohui , Zhou BoLin , Hou Zhen , Wei YanFu , Wen Rong , Ji Ting , Wei Yi , Hao YuYing , Cui YanXia 
Published: November 2021

Abstract
The outstanding optoelectrical properties and high-quality factor of whispering gallery mode perovskite nanocavities make it attractive for applications in small lasers. However, efforts to make lasers with better performance have been hampered by the lack of efficient methods for the synthesis and transfer of perovskite nanocavities on desired substrate at the quality required for applications. Here, we report transfer printing of perovskite nanocavities grown by chemical vapor deposition from mica substrate onto SiO2 substrate. Transferred perovskite nanocavity has an RMS roughness of ~1.2 nm and no thermal degradation in thermal release process. We further use femtosecond laser to excite a transferred perovskite nanocavity and measures its quality factor as high as 2580 and a lasing threshold of 27.89 µJ/cm2 which is almost unchanged as compared with pristine perovskite nanocavities. This method represents a significant step toward the realization of perovskite nanolasers with smaller sizes and better heat management as well as application in optoelectronic devices.
Optimal Timing for Intermittent Administration of Parathyroid Hormone (1-34) for Distraction Osteogenesis in Rabbits
Authors: Inada Narisaku , Ohata Tetsuya , Maruno Hideto , Morii Takeshi , Hosogane Naobumi , Ichimura Shoichi 
Published: November 2021

Abstract
BackgroundTo date, the usefulness of parathyroid hormone (PTH (1-34)) in distraction osteogenesis has been reported in several studies. We aimed to determine the optimal timing of PTH (1-34) administration in a rabbit distraction osteogenesis model.MethodsThe lower hind leg of a Japanese white rabbit was externally fixed, and tibial osteotomy was performed. One week after the osteotomy, bone lengthening was carried out at 0.375 mm/12 h for two weeks. After five weeks, the lower leg bone was collected. Bone mineral density (BMD), peripheral quantitative computed tomography (pQCT), micro-computed tomography (micro-CT), and mechanical tests were performed on the distracted callus. The rabbits were divided into three groups according to the timing of PTH administration: four weeks during the distraction and consolidation phases (group D+C), two weeks of the distraction phase (group D), and the first two weeks of the consolidation phase (group C). A control group (group N) was administered saline for four weeks during the distraction and consolidation phases. Furthermore, to obtain histological findings, lower leg bones were collected from each rabbit at two, three, and four weeks after osteotomy, and tissue sections of the distracted callus were examined histologically.ResultsThe BMD was highest in group C and was significantly higher than group D. In pQCT, the total cross-sectional area was significantly higher in groups D+C, D, and C than group N, and the cortical bone area was highest in group C and was significantly higher than group D. In micro-CT, group C had the highest bone mass and number of trabeculae. Regarding the mechanical test, group C had the highest callus failure strength, and this value was significantly higher compared to group N. There was no significant difference between groups D and N. The histological findings revealed that the distracted callus mainly consisted of endochondral ossification in the distraction phase. In the consolidation phase, the chondrocytes were almost absent, and intramembranous ossification was the main type of ossification.ConclusionWe found that the optimal timing of PTH (1-34) administration is during the consolidation phase, which is mainly characterized by intramembranous ossification.
Improving the Mechanical Ductility and Toughness of Injection-molded Polylactide Pieces by the Dual Incorporation of Liquor Waste Derived Spent Coffee Grounds and Oligomers of Lactic Acid
Authors: Terroba-Delicado Enrique , Fiori Stefano , Torres-Giner Sergio , Gomez-Caturla Jaume , Montanes Nestor , Sanchez-Nacher Lourdes 
Published: November 2021

Abstract
This work puts the Circular Bioeconomy’s concept into action, originally valorizing residues from the beverage liquor coffee industry into reinforcing fillers for green composites of polylactide (PLA). The as-received spent coffee grains derived from liquor waste were first milled to obtain the so-called spent coffee grounds (SCGs), which were then incorporated at 20 wt.% into PLA by extrusion. With the aim of improving the compatibility between the biopolyester and the lignocellulosic particles, two oligomers of lactic acid (OLAs), namely OLA2 and OLA2mal, being the latter functionalized with maleic anhydride (MAH), were both added during the extrusion process at 10 wt.%. The resultant compounded pellets were finally shaped into pieces by injection molding for characterization. Results showed that, as opposite to most claims published in the literature of PLA composites based on lignocellulosic fillers derived from soluble coffee wastes, the incorporation of liquor waste derived SCGs increased the ductility of the pieces by nearly 280% due to their high coffee oil content. The incorporation of OLA2 and OLA2mal contributed to improve the impact strength of the pieces by approximately 6% and 12.6%, respectively. The higher performance of OLA2mal was ascribed to a reduction of crystallinity in the green composite due to the chemical interaction by the MAH groups. However, the incorporation of SCGs into PLA slighlty reduced the thermal stability and yielded a dark-to-brown color, whereas it also delayed the disintegration rate of the pieces in controlled compost soil. Therefore, the results attained herein open up novel opportunities for the development of green composites of PLA with higher ductility and toughness through the valorization of liquor coffee wastes.
Can sarcopenia index serve as a predictor of myocarditis from mRNA based COVID-19 vaccine, insights from clustered cases and potential involvement of micro-RNAs in its pathogenesis.
Authors: AbdelMassih Antoine , Shershaby Meryam El , Gaber Hanya , Ismail Habiba-Allah , El-Hussseiny Nadine , Amin Abeer , ElBoraie Aly , Ayad Aya , Menshawey Esraa , Sefein Fady , Osman Ibrahim , Hanafy Maram , AbdelAziz Mariam , Arsanyous Mariem , Khaled-Ibn-El-Walid Mariam , Tawfik Marwa , Habib Menna , Mansour Mina , Ashraf Mirette , Khattab Mohamed , AlShehry Nada , Hafez Nada , ElDeeb Naheel Essam , Ashraf Nirvana , Khalil Noha , AbdElSalam Noheir , Shebl Noura , Hafez Nouran , Youssef Nourhan , Bahnan Odette , Ismail Passant , Kelada Peter , Menshawey Rahma , Saeed Rana , Husseiny Reem , Yasser Reem , Sharaf Safa , Adel Veronia , Naeem Youstina , Nicola Youstina , Kamel Aya , Hozaien Rafeef , Fouda Raghda 
Published: November 2021

Abstract
Background: With the current mass international roll out of several vaccines against SARS-Cov-2, several reports of unheeded complications have made headlines. One of which involves myocarditis with the now FDA fully approved vaccine, Pfizer, and others. We hypothesize through this study that a dysregulated micro-RNA response resulting from such type of vaccines can be involved in triggering myocarditis. Methodology: Embase, Medline and the Cochrane Central Register were used to search for specific keywords such as “mRNA COVID-19 vaccines” AND “Myocarditis” for relevant publications up to 1st of September 2021. The systematic review was performed using PRISMA protocolResults:Literature review has identified 26 cases series and reports involving the development of myocarditis from mRNA vaccines, a total of 89 patients were included. Age range was clearly identified in 66 patients. Among those 66 patients, 94% were below 50 years of age, also out of 89 patients, 94% were males. Myocarditis developed, after a median time of 72 hours of the 2nd dose. 90 of cases of myocarditis developed myocarditis after the 2nd dose, the few patients developing myocarditis after the first dose were either predisposed by a history of myocarditis or a history of previous COVID-19 infection. Conclusion:In conclusion, interpretation of the results in view of the suggested hypothesis, reveals that the micro-RNAs implicated in myocarditis in general are as well implicated in the pathogenesis of severe COVID-19, this can explain why patients having a first dose with a history of COVID-19 can develop myocarditis from mRNA vaccines, also the relatively higher likelihood of this complication in males and younger aged individuals can be explained by the upregulation of key myocarditis related miRNAs in those two strata, due to higher muscle mass and suggests performing a sarcopenia index in recipients of the vaccine to correlate it with the likelihood of this complication. This could later set a cut-off of this easy bed-side index to stratify cases a higher risk of this rare complication.
Which micro-organisms are transferred by healthcare personnel between hospital and home?
Authors: ORHAN Zerife , SÖNMEZ Mehtap , KAYIŞ Arzu , ARAL Murat 
Published: November 2021

Abstract
Background: The aim of ths study was to determine which micro-organisms are transferred from home to hospital, and which from hospital to home, by the hands of healthcare personnel. Methods: A total of 10 doctors and 53 nurses, selected at random according to the clinics where they worked, were included. The study data were collected in two stages. In the first stage, the study participants completed a personal information form. In the second stage, samples were taken from the right and left hands of the healthcare personnel on entering and leaving the hospital.Results: According to the samples taken, there was determined to be greater bacteria production on the hands of the healthcare personnel when entering the hospital. The greatest production was in the least washed area of the right hand (93.7% on entry, 74.6% on exit). Nurses and those working in surgical clinics were seen to have greater bacteria production on both entry to and exit from the hospital compared to other healthcare workers. Conculusion: The study results showed that just as healthcare personnel transferred some micro-organisms from home to hospital on their hands, they also transferred some bacteria to home on leaving the hospital. With the necessary precautions taken to prevent the transfer of micro-organisms to or from hospital, the prevalence of hospital infections will decrease.
Beam Propagation Factor of Hollow Higher-order Cosh-Gaussian Beams
Authors: Saad Faroq , Ebrahim Ahmed Abdulrab Ali , Belafhal Abdelmajid 
Published: November 2021

Abstract
Based on the second-order moments definition, we investigate in this paper the beam propagation factor of new mathematical model of Hollow higher-order Cosh-Gaussian (HhCG) beams. Two analytical formulae of the M2-factor of HhCG beams are derived. Moreover, numerical simulations are developed to illustrate the effects of the beams orders n and l, the parameter δ and the beam waist ω0 on the M2-factor. The result shows a more general characteristic of higher-order Cosh-Gaussian, Cosh-Gaussian and the fundamental Gaussian beams can be obtained as specials cases of HhCG beams.
PET Imaging Using [18F]olaparib in Mouse Models of Malignant Glioma: Considerations for Molecular Imaging and Radionuclide Therapy Targeting PARP
Authors: Chan Chung Ying , Hopkins Samantha L. , Guibbal Florian , Pacelli Anna , Torres Julia Baguña , Mosley Michael , Lau Doreen , Isenegger Patrick , Chen Zijun , Wilson Thomas C. , Dias Gemma , Hueting Rebekka , Gouverneur Véronique , Cornelissen Bart 
Published: November 2021

Abstract
PurposeRadiopharmaceuticals targeting poly(ADP-ribose) polymerase (PARP) have emerged as promising agents for cancer diagnosis and therapy. PARP enzymes are expressed in both cancerous and normal tissue. Hence, the injected mass, molar activity and potential pharmacological effects are important considerations for the use of radiolabelled PARP inhibitors for diagnostic and radionuclide therapeutic applications. Here, we performed a systematic evaluation by varying the molar activity of [18F]olaparib and the injected mass of [TotalF]olaparib to investigate the effects on tumour and normal tissue uptake in two subcutaneous human glioblastoma xenograft models.Methods[18F]Olaparib uptake was evaluated in the human glioblastoma models: in vitro on U251MG and U87MG cell lines, and in vivo on tumour xenograft-bearing mice, after administration of [TotalF]olaparib (varying injected mass: 0.04-8.0 µg, and molar activity: 1-320 GBq/μmol).ResultsSelective uptake of [18F]olaparib was demonstrated in both models. Tumour uptake was found to be dependent on the injected mass of [TotalF]olaparib (µg), but not the molar activity per sé. An injected mass of 1 μg resulted in the highest tumour uptake (up to 6.9 ± 1.3%ID/g), independent of the molar activity. In comparison, both the lower and higher injected masses of [TotalF]olaparib resulted in lower relative tumour uptake (%ID/g; P<0.05). Ex vivo analysis of U87MG xenograft sections showed that the heterogeneity in [18F]olaparib intratumoural uptake correlated with PARP1 expression. Substantial upregulation of PARP1-3 expression was observed after administration of [TotalF]olaparib (>0.5 µg).Conclusion﻿Our findings show that the injected mass of [TotalF]olaparib has significant effects on tumour uptake. Moderate injected masses of PARP inhibitor-derived radiopharmaceuticals may lead to improved relative tumour uptake and tumour-to-background ratio for cancer diagnosis and radionuclide therapy.
Correlation between Job Burnout and Fear of COVID-19 among ICU and CCU Nurses
Authors: Golabi Prof. Fatemeh , Aghdam Prof. Mohammad Bagher Alizadeh , Akbarian Hamed , Mazraehshadi Mir Mojtaba Hosseini 
Published: November 2021

Abstract
Background: Occupational burnout among nurses is one of the major factors which affect the quality of nursing care. Assessing the relationship between burnout and its associated factors is one of the most basic things that should be done so that later, actions can be taken to reduce burnout. Fear of COVID-19 is one of the factors that can increase burnout of nurses during the Coronavirus Disease 2019(COVID-19) pandemic.Aim: To investigate the relationship between job burnout and fear of COVID-19 among ICU and CCU nurses.Methods: The Maslach Burnout Inventory (MBI) and the Fear of COVID-19 Scale (FCV-19S) were distributed to ICU and CCU nurses (n = 170) at Shahid Madani Cardiac Hospital, Tabriz, Iran, and the correlation between job burnout and fear of COVID-19 was calculated.Results: The results show that the level of emotional exhaustion and reduced personal accomplishment among participants of this study is average, and depersonalization is at a low level. Also, the level of fear of coronavirus is below average among the respondents. The research showed that emotional exhaustion and fear of COVID-19 were positively correlated (p < 0.05), but there was not any significant correlation between depersonalization and fear of Coronavirus; as the relationship between reduced personal accomplishment and fear of COVID-19. In addition, there were significant correlations between age and reduced personal accomplishment, as well as marital status and reduced personal accomplishment (p < 0.05). On the other hand, the results showed that there were not any significant correlations between gender and burnout dimensions, nor between educational degree and burnout dimensions.Conclusion: As job burnout reduces the quality of nursing care, managers must take strategies that reduce job burnout. One of the strategies that they can take is to reduce the fear of COVID-19 by taking wise strategies.