bluuebunny/crossref_metadata_2025_split huggingface dataset:
La industria automotriz en México durante las recientes crisis: reorganización productiva y perspectiva geopolítica
Authors: Arciniega Rosa Silvia 
Published: February 2025

La crisis sanitaria de 2020-2021, la escasez de microcomponentes desde 2021 hasta la fecha, y las múltiples tensiones geopolíticas en curso (especialmente entre Estados Unidos y China) han tenido un impacto significativo y continuo en la industria automotriz. Estos eventos han generado disrupciones en las cadenas de suministros, evidenciando las vulnerabilidades de una industria que trabaja bajo el sistema de producción Justo a Tiempo. En este contexto, el nearshoring ha adquirido relevancia como estrategia para asegurar una cadena de suministro resiliente y eficiente en lo que respecta a los parámetros temporales y económicos. El objetivo de esta investigación es describir el panorama de la industria automotriz en México durante las recientes crisis –iniciadas en el año 2020 y que aún persisten impactando el contexto del comercio internacional–, identificando el nearshoring como una estrategia de negocios vinculada a una reestructuración productiva con el propósito de gestionar los riesgos en la compleja cadena de producción. Se plantea que el contexto postpandémico insta a una reconsideración de la estructura de las actividades productivas de la industria automotriz mexicana, la cual tiene un impacto no solo a nivel sectorial, sino también regional. Además, el aumento de costos de producción en China también posiciona a México como un socio comercial atractivo que posee la posibilidad de iniciar operaciones relacionadas con productos similares a los provenientes de Asia. Las reestructuraciones productivas y geográficas, que incluyen procesos de deslocalización y el retorno significativo de la producción a los países de origen (relocalización de empresas y divisiones), imponen la necesidad de considerar el rol que desempeñará México en el cambiante contexto geopolítico y económico.
Eliciting Physiological and Biochemical Effects of Agronomic Management in Chinese Potato [Plectranthus rotundifolius (Poir) Spreng]
Authors: Arunjith P. , Isaac Sheeba Rebecca , Pooja A.P. 
Published: February 2025

Background: Chinese potato [Plectranthus rotundifolius (Poir.) J.K. Morton] also known as coleus is cultivated in many parts of the world for its edible tubers. Despite a high production potential, the productivity of Chinese potato appears to be limited by a lack of balance between the source and sink capacities. The objective of the study was to investigate the effect of agronomic management practices viz., planting methods, nutrient management and growth promoters on physiological and biochemical responses in Chinese potato. Methods: An investigation was undertaken at College of Agriculture, Vellayani, Thiruvananthapuram during October to February of 2019 - ‘20 and repeated in 2020 - ’21 in split plot design with five methods of planting as main plots (bed/ridge method of planting with 30 cm x 15 cm, 30 cm x 30 cm and mound method of planting with 30 cm x 30 cm spacing) and six combinations of nutrient management practices (60:30:120 kg NPK/ha with and without PGPR Mix 1) and growth promoters (humic acid, benzyl adenine and water spray) as sub-plot treatments replicated four times. Result: The results revealed the superiority of bed method of planting at 30 cm x 15 cm spacing with the application of 60:30:120 kg NPK ha-1 + PGPR Mix 1 + humic acid (m1n1g1) on physiological attributes viz. DMP, CGR and LAI was found most productive resource management practice in Chinese potato.
Production and Marketing of Chilli in Middle Gujarat
Authors: Pundir R.S. , Vahoniya D.R. , Rajwadi Alvira 
Published: February 2025

Background: Gujarat state has favorable climatic condition for fruits and vegetables cultivation. The study was taken up to find the cost and return from chilli cultivation and their marketing channels. Methods: The data were collected using primary survey method while cost concept and Acharya’s formula were used to analyze the data in this study. Result: The study revealed that cost C2 was ₹ 201738.0 per ha in chilli cultivation while gross income was ₹ 485369.6 per ha. The net return was ₹ 278738 per ha and benefit cost ratio over total cost was 2.41 in the study area. Among the three-marketing channel found in the study area, channel III (5.59) was the most efficient marketing channel. This implies that need to encourage the marketing of chilli through channel III in the study area. Labour shortage and higher input prices were the major production constraint while less price received by farmers and labour problems were the major marketing constraint faced by farmers in the study area. This implies that there is need to use advanced mechanical tools and technology while production and marketing which ultimately lead to strengthen supply chain and reduce post-harvest losses.
THE EVOLUTIONARY INNOVATION OF CORAL COLONIZATION ON MOTILE GASTROPOD SHELLS AROSE SHORTLY AFTER THE GREAT ORDOVICIAN BIODIVERSIFICATION EVENT IN BALTICA
Authors: Vinn Olev , Liang Kun , Isakar Mare , Alkahtane Abdullah A. , Al Farraj Saleh , El Hedeny Magdy 
Published: February 2025

Abstract
Studying symbiotic interactions provides valuable insights into the ecology of extinct organisms and the broader mechanisms of evolution. Here we describe the earliest symbiotic associations between colonial corals and gastropods from the Late Ordovician of Estonia. Tabulate corals of the genus Heliolites were found in association with gastropod Ruedemannia borkholmiensis, Pachystrophia sp., and Hormotoma scorbiculata. Heliolitids encrusted only mature gastropod specimens presumably due to the need for an ample space to grow. During the Katian and Hirnantian in Estonia, gastropods provided a hard substrate for corals in areas where the seafloor was otherwise soft. The corals can use their hosts to escape unfavorable environmental conditions and withstand burial. The calcareous layer deposited by the coral strengthened the gastropod shell, making it more resilient and resistant to breakage in the event of predation by durophagous organisms or hydrodynamic events. The occurrence of the same species of gastropods and heliolitids in the Pirgu and Porkuni regional stages, independently, suggests that the symbiotic relationship between them was facultative for both partners. Taking into account the potential benefits and drawbacks involved, mutualism appears to best describe the associations between heliolitids and gastropods in the Late Ordovician of Estonia. The analysis of studied specimens suggests that corals began to colonize gastropod shells as early as the late Katian, either alive or secondarily inhabited by other invertebrates. This indicates that the innovation of coral colonization of motile gastropod shells may have emerged after the Great Ordovician Biodiversification Event (GOBE) in Baltica.
WITHDRAWN: Model prediction of suicidal behavior in first hospitalization patients with major depression disorder: a cross-sectional study based on a large sample
Authors: Hu Suoya , Zhang Lin , Liu Xuebing , Li Yi , Ma Jun 
Published: February 2025

Abstract

The full text of this preprint has been withdrawn by the authors since they no longer stand by the findings/conclusions of this work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Interaction between Neighborhood Exposome and Genetic Risk in Child Psychotic-like Experiences
Authors: Chen Yinxian , Yuan Qingyue , Dimitrov Lina , Risk Benjamin , Ku Benson , Huels Anke 
Published: February 2025

Abstract

Persistent distressing psychotic-like experiences (PLE) among children may be driven by genetics and neighborhood environmental exposures. However, the gene-environment interaction to persistent distressing PLE is unknown. The study included 6,449 participants from the Adolescent Brain and Cognitive Development Study. Genetic risk was measured by a multi-ancestry schizophrenia polygenic risk score (SCZ-PRS). Multi-dimensional neighborhood-level exposures were used to form a neighborhood exposome (NE) score. SCZ-PRS was not statistically significantly associated with odds of persistent distressing PLE (OR = 1.04, 95% CI: 0.97, 1.13, P = 0.280), whereas NE score was (OR = 1.15, 95% CI: 1.05, 1.26, P = 0.003). The association between NE score and persistent distressing PLE was statistically significantly attenuated as SCZ-PRS increased (OR for interaction = 0.92, 95% CI: 0.86, 1.00, P = 0.039). The findings indicate that persistent distressing PLE may be driven by detrimental neighborhood exposures, particularly among children with low genetic risks.
OmiGA: A Toolkit for Ultra-efficient Molecular Trait Analysis in Complex Populations
Authors: Fang Lingzhao , Teng Jinyan , Zhang Wenjing , Gong Wentao , Chen Jiajian , Gao Yahui , Zhang Zhe 
Published: February 2025

Abstract

Molecular quantitative trait loci (molQTL) mapping is one of the most popular approaches to systematically characterize functional impacts of genomic variants, leading to advanced understanding of the regulatory mechanisms underpinning complex traits and diseases. However, when applied to high-throughput molecular phenotypes, the existing molQTL mapping tools often implement simple linear models, overlooking complex inter-individual relatedness, leading to false positives and insufficient statistical power. Here, we introduce the Omics Genetic Analysis toolkit (OmiGA), an ultra-efficient linear mixed model (LMM) based toolkit, for molQTL mapping in populations with complex relatedness. Both computational simulations and real data analyses demonstrated that OmiGA outperformed the existing popular tools regarding molQTL discovery power, fine mapping of causal variants, colocalization of molQTL and trait associations, and computational efficiency. In summary, we recommend OmiGA for molQTL mapping in populations with complex relatedness, for example, those in the Farm animal Genotype-Tissue Expression (FarmGTEx) project and family-based molQTL studies in humans.
The Correlation Between Middle Frontal Gyrus Cortical Thickness and Working Memory in First-episode Treatment-naïve Major Depressive Disorder
Authors: Liu Chenyu , Li Hehua , Feng Shixuan , Zhang Ziyun , Huang Miaolan , Li Junhao , Huang Dongchang , Huang Yuanyuan , Wu Kai , Wu Fengchun 
Published: February 2025

Abstract

Background: Cognitive impairment is regarded as a pivotal symptom of Major Depressive Disorder (MDD). Previous studies have indicated the presence of abnormalities in cortical thickness (CT) in patients with MDD. However, the relationship between cognitive performance and CT abnormalities in patients with MDD remains unclear. Our study purposed to survey the changes in CT in patients with MDD and their relationship with cognitive impairment.
Methods: A total of 105 patients with first-episode treatment-naïve MDD and 53 healthy controls (HCs) received T1-weighted magnetic resonance imaging (MRI) and a series of neuropsychological tests. Initially the differences in CT and cognitive performance between patients with MDD and HCs were contrasted. Subsequently, the correlation between CT and cognitive performance were analyzed for significant changes.
Results: All five cognitive dimensions were significantly different between patients with MDD and HCs. Meanwhile, the CT of the bilateral precentral gyri and right middle frontal gyrus were reduced in the MDD group. Besides, the CT of the right middle frontal gyrus shows a positive relationship with working memory dimension scores of the MDD group.
Conclusion: CT abnormalities in patients with MDD are correlated with cognitive performance.
Improving reverse engineering processes using C-K theory of design
Authors: Kutari Lukita Dea , Ura Sharifu 
Published: February 2025

Abstract

This study presents how to improve reverse engineering processes using the C-K theory of design. First, conventional reverse engineering (which relies on large point clouds of the object to be reverse-engineered obtained through 3D scanning) and its characteristics are studied. Next, the conventional reverse engineering processes are studied using the C-K theory of design, highlighting areas for improvement. Afterward, a new reverse engineering method based on the C-K theory of design is proposed. This method integrates three types of knowledge: creative definitional knowledge, informal inductive knowledge, and deductive knowledge. These types of knowledge facilitate the generation of planner point clouds, capturing important features of the object to be reverse-engineered. These point clouds can be easily converted into a 3D CAD model, supporting digitization and fabrication. The efficacy of the proposed C-K theoretic reverse engineering is demonstrated by reverse engineering a gear-pinion set. Unlike conventional reverse engineering, which mainly focuses on replicating a given object, this new approach takes a different path; it enables the creation of innovative solutions that achieve the same functionality as the original object. This shift from strict replication to creativity is a major advantage. By leveraging this advantage, the proposed reverse engineering method can be applied to (for example) remanufacturing problems, which will be deviled into the next phase of this study.
Genetic analysis of two heterozygous SMPD1 variants in a pediatric Niemann-Pick disease patient
Authors: Chen Yixiao , Zhu Chuchu , Lin Xishi , Zhao Jian , Yao Weimiao , Luo Qiong 
Published: February 2025

Abstract

Background
Niemann-Pick disease (NPD), also known as acid sphingomyelinase deficiency, represents a group of rare genetic disorders first described in 1914. SMPD1 is a crucial gene in this disease, which encodes the enzyme sphingomyelinase essential for the breakdown of sphingomyelin, a component of cell membranes. Mutations in the SMPD1 gene disrupt this enzymatic activity, leading to the accumulation of sphingomyelin in lysosomes.
Methods
We investigated a a child diagnosed with Niemann-Pick disease and his parents. Whole exome sequencing, in silico analysis, minigene constructs, transfection, RT-PCR were used to analyze the genotype and mutations of the proband and his parents.
Results
Whole exome sequencing revealed that the proband had compound heterozygous mutations in the SMPD1 gene: c.1497_1498GT > AC and c.1486 + 5G > C, inherited from his father and mother, respectively. The c.1486 + 5G > C mutation resulted in the loss of exon 5, seriously affecting the protein function. This mutation was classified as pathogenic or suspected pathogenic based on HGMD data and ACMG guidelines.
Conclusion
This study identified two heterozygous pathogenic SMPD1 variants (c.1497_1498GT > AC and c.1486 + 5G > C) in a pediatric patient with Niemann-Pick disease. The SMPD1 gene splicing site mutation c.1486 + 5G > C leads to the deletion of exon 5, significantly impacting protein function. These new findings expand the variant spectrum of SMPD1 mutations causing NPD and contribute to a better understanding of the genetic basis of the disease.
Seismic design and analysis, vulnerability assessment of RC frame building, Juba, South Sudan
Authors: Samuel Mabor Achol , Xiong Ergang , Lekeufack Beco Chenadaire 
Published: February 2025

Abstract

Reinforced concrete (RC) is a widely used building material known for its strength and durability. By combining the compressive strength of concrete with the tensile properties of steel, RC structures can withstand significant loads, making them ideal for buildings and critical infrastructure. This adaptability has made RC a preferred choice in urban construction, especially in developing regions such as Juba in South Sudan. However, RC buildings in Juba are particularly vulnerable due to the lack of formal seismic design standards, inadequate reinforcement details, and limited awareness of earthquake-resistant practices. Consequently, many regional structures need to be better designed to withstand seismic forces, increasing the risk of failure during earthquakes. This study evaluates the seismic behavior of a typical G + 2 RC frame building in Juba, designed initially to withstand gravity loads when subjected to seismic forces. Incremental Dynamic Analysis (IDA) and Time History Analysis (THA) with SAP2000 v23.2.0 software analyze critical components such as beam-column connections. The seismic loads were calculated using the equivalent static method according to the IS:1893–2016 standard. The results show that although the building meets the criteria to prevent collapse, significant weaknesses in the beam-to-column connections affect its seismic performance. These results underscore the need for increased reinforcement and the urgent development of seismic design guidelines and retrofit strategies specific to construction practices in Juba. This study provides important insights for engineers and policymakers to improve the seismic resilience of RC buildings, protect infrastructure, and enhance public safety in the rapidly urbanizing regions of South Sudan.
FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN GEL EKSTRAK ETANOL DAUN JERUK NIPIS (Citrus aurantifolia) DENGAN KOMBINASI EKSTRAK ETANOL DAUN KELOR (Moringa oleifera Lam)
Authors: Fatmawati Annisa 
Published: February 2025

Penuaan dini merupakan proses penuaan kulit yang terjadi lebih cepat sebelum waktunya. Penyebab penuaan dini terdiri dari faktor internal dan faktor eksternal. Faktor eksternal yang paling berperan dalam penuaan dini merupakan radikal bebas. Daun jeruk nipis (<em>Citrus aurantifolia</em>) dengan kombinasi daun kelor (<em>Moringa oleifera </em>Lam) keduanya mengandung flavonoid yang berfungsi sebagai antioksidan yang dapat menangkal radikal bebas. Kandungan zat aktif yang dimiliki daun jeruk nipis (<em>Citrus aurantifolia</em>) dan daun kelor (<em>Moringa oleifera </em>Lam) mengandung flavonoid seperti kuersetin, apigenin, rutin, kaempferol, hesperidin dan nobiletin yang bersifat sebagai antioksidan. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antioksidan dari formulasi sediaan gel daun jeruk nipis (<em>Citrus aurantifolia</em>) dengan kombinasi daun kelor (<em>Moringa oleifera </em>Lam) Ekstraksi dilakukan secara maserasi menggunakan pelarut etanol 70%, ekstraksi yang diperoleh diformulasi menjadi sediaan gel dengan variasi perbandingan ekstrak kombinasi daun jeruk nipis dan daun kelor 1:1, 1:2 dan 2:1. Metode yang digunakan eksperimental laboratorium dengan sampel daun jeruk nipis dan daun kelor yang dibuat menjadi sediaan gel dan kuersetin sebagai pembanding. Formula yang diperoleh diuji evaluasi sifat fisik dan uji aktivitas antioksidannya menggunakan metode DPPH. Hasil evaluasi sifat fisik sediaan gel dari keempat formulasi memenuhi persyaratan evaluasi sifat fisik sediaan gel yang meliputi uji organoleptik, uji homogenitas, uji pH, uji daya lekat, dan uji daya sebar. Hasil nilai aktivitas antioksidan dari sediaan gel kombinasi ekstrak etanol daun jeruk nipis dengan ekstrak etanol daun kelor formula I (1:1) 80,04 ppm, formula II (1:2) 143,67 ppm, formula III 94,21ppm, dan basis 328,26 ppm. Kesimpulan penelitian ini menunjukkan sediaan gel formula I dan III termasuk dalam kategori antioksidan kuat, sedangkan formula II dengan komposisi EEDJN:EEDK (1:2) termasuk dalam kategori antioksdian sedang.
User Personas for eHealth Regarding the Self-Management of Depressive Symptoms in People Living With HIV: Mixed Methods Study
Authors: Zhao Ting , Tang Chulei , Ma Jun , Yan Huang , Su Xinyi , Zhong Xueyuan , Wang Honghong 
Published: February 2025

Background
eHealth has enormous potential to support the self-management of depressive symptoms in people living with HIV. However, a lack of personalization is an important barrier to user engagement with eHealth. According to goal-directed design, personalized eHealth requires the identification of user personas before concrete design to understand the goals and needs of different users.

Objective
This study aimed to identify user personas for eHealth regarding the self-management of depressive symptoms in people living with HIV and explore the goals and needs of different user personas for future eHealth.

Methods
We used an explanatory sequential mixed methods design at the First Hospital of Changsha City, Hunan Province, China, from April to October 2022. In the quantitative phase, 572 people living with HIV completed validated questionnaires with questions related to demographics, self-efficacy, self-management abilities of depressive symptoms, and eHealth literacy. Latent profile analysis was performed to identify different user personas. In the qualitative phase, 43 one-to-one semistructured interviews across different user personas were conducted, transcribed verbatim, and analyzed using conventional content analysis. The findings from both phases were integrated during the interpretation phase.

Results
Three types of user personas could be identified, including “high-level self-managers” (254/572, 44.4%), “medium-level self-managers” (283/572, 49.5%), and “low-level self-managers” (35/572, 6.1%). High-level self-managers had relatively high levels of self-efficacy, self-management abilities of depressive symptoms, and eHealth literacy. High-level self-managers had a positive attitude toward using eHealth for the self-management of depressive symptoms and desired access to self-management support for depressive symptoms from eHealth with high usability. Medium-level self-managers had relatively medium levels of self-efficacy, self-management abilities of depressive symptoms, and eHealth literacy. Medium-level self-managers felt burdened by using eHealth for the self-management of depressive symptoms and preferred to access self-management support for HIV from eHealth with privacy. Low-level self-managers had relatively low levels of self-efficacy, self-management abilities of depressive symptoms, and eHealth literacy. Low-level self-managers had an acceptable attitude toward using eHealth for the self-management of depressive symptoms and desired access to professional guidance from eHealth with privacy and no cost (“free of charge”).

Conclusions
The 3 user personas shed light on the possibility of personalized eHealth to support the self-management of depressive symptoms in different people living with HIV. Further research is needed to examine the generalizability of the user personas across study sites.
Membayangkan Penyelenggaraan Kearsipan Lembaga Negara di Ibu Kota Nusantara:
Authors: Azmi Azmi 
Published: February 2025

The relocation of the capital city of the Republic of Indonesia from Jakarta to the capital city of Nusantara (IKN) East is an effort to create a government center that has the character of a smart city and accommodates Indonesia's visionary development for the long term.. Accomplishing this of course requires support for an ideal records keeping of the state institution in IKN to ensure the availability of state records as a source of government data/information and provide admissible evidence. This research aims to provide an overview of an ideal records keeping of the state institution in IKN. This research uses a qualitative approach with descriptive methods. Based on the research results, it can be concluded that the ideal records keeping of the state institution in IKN is the records keeping that transforms from a manual system to an electronic/digital system system, covering four intertwined aspects of archives, namely: modernizing policies, strengthening guidance, modernizing records management systems, and revitalizing resources.