bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multinational evaluation of the BioFire® FilmArray® Pneumonia plus Panel as compared to standard of care testing
Authors: Ginocchio Christine C. , Garcia-Mondragon Carolina , Mauerhofer Barbara , Rindlisbacher Cory ,   and the EME Evaluation Program Collaborative, Forcelledo L. , Fernández J. , Lienhard R. , Kerschner H. , Rossolini G. M. , Armand-Lefèvre L. , d’Humières C. , Cambau E. , Benmansour H. , Cavallo R. , Altwegg M. , Berlinger L. , Bonnet R. , Saint-Sardos P. , Meex C. , Lavigne J. P. , Leveque N. , Broutin L. , Cattoir V. , Auger G. , Pereira H. , Paitan Y. , Verroken A. , Pailhoriès H. , Lemarié C. , Martinetti-Lucchini G. , Frigerio Malossa S. , Sanguinetti M. , Spanu T. , Vandenesch F. , Poyart C. , Loubinoux J. , Mira J. P. , Bonacorsi S. , Cointe A. , Muñoz P. , Kestler M. , Esteva C. , Queralt X. , García-Rodríguez J. , Gómez M. D. , López-Hontangas J. L. , Ghisetti V. , Burdino E. , Schubert S. , Mencacci A. , Allegrucci F. , Rozemeijer W. , Paternotte N. , Allard A. , Re M. C. , Ambretti S. , Skov M. , Agergaard C. N. , Subudhi P. , Wichelhaus T. A. , Egli A. , Hinic V. , Alcock A. , Banavathi K. , Tiberio C. , Ruocco G. , Atripaldi L. 
Published: March 2021

AbstractThis study compared standard of care testing (SOC) to BioFire® FilmArray® Pneumonia plus Panel (PNplus). PNplus detects 15 bacteria with semiquantitative log bin values, 7 antibiotic resistance markers, three atypical bacteria (AB), and eight viral classes directly from bronchoalveolar lavage-like specimens (BLS) and sputum-like specimens (SLS). Fifty-two laboratories from 13 European countries and Israel tested 1234 BLS and 1242 SLS with PNplus and SOC. Detection rates and number of pathogens/samples were compared for PNplus pathogens. PNplus bin values and SOC quantities were compared. Three thousand two hundred sixty-two bacteria in PNplus were detected by PNplus and/or SOC. SOC detected 57.1% compared to 95.8% for PNplus (p ≤ 0.0001). PNplus semiquantitative bin values were less than SOC, equal to SOC, or greater than SOC in 5.1%, 25.4%, and 69.6% of results, respectively. PNplus bin values were on average ≥ 1 log than SOC values (58.5% 1–2 logs; 11.0% 3–4 logs). PNplus identified 98.2% of MRSA and SOC 55.6%. SOC detected 73/103 AB (70.9%) and 134/631 viruses (21.2%). PNplus detected 93/103 AB (90.3%) and 618/631 viruses (97.9%) (p ≤ 0.0001). PNplus and SOC mean number of pathogens/samples were 1.99 and 1.44, respectively. All gram-negative resistance markers were detected. PNplus and SOC results were fully or partially concordant for 49.1% and 26.4% of specimens, respectively. PNplus was highly sensitive and detected more potential pneumonia pathogens than SOC. Semiquantification may assist in understanding pathogen significance. As PNplus generates results in approximately 1 h, PNplus has potential to direct antimicrobial therapy in near real time and improve antimicrobial stewardship and patient outcomes.
Child and Adolescent Mental Health Training Programs for Non-specialist Mental Health Professionals in Low and Middle Income Countries: A Scoping Review of Literature
Authors: Raj Vijay , Raykar Vibhay , Robinson Ainsley M. , Islam Md Rafiqul 
Published: March 2021

AbstractLarge treatment deficits in child and adolescent mental health (CAMH) care exist in low and middle income countries (LMICs). This study reviewed CAMH training programs for non-specialist health professionals (NSHPs) in LMICs. Multiple databases were searched for peer-reviewed articles describing programs from 2005 to 2018. Educational source materials, trainee evaluation methods, and perspectives on teaching methods, course content and scheduling were studied. Six programs were identified. NSHPs were most appreciative of training which included case-based discussions, role plays and clinical demonstrations that were relevant to local contexts. A need for less intense and more flexible timetables to enable reflection was identified. WHO’s mental health gap action program intervention guide (mhGAP-IG) and international association of child and adolescent psychiatrists and allied professionals resources should be used; they are free, easily accessible, and developed with extensive international contributions. Additionally, mhGAP-IG assessment tool encourages mutual learning, thereby iteratively enhancing training programs.
Umgang mit sexueller und geschlechtlicher Vielfalt
Authors: Baer Steffen , Höblich Davina 
Published: March 2021

ZusammenfassungDer Umgang mit Diversität gehört zu den zentralen Aufgaben von Professionellen in der Sozialen Arbeit. Dieser wird entlang der Befunde mehrerer empirischer Projekte zum Umgang von Fachkräften mit geschlechtlicher und sexueller Orientierung beleuchtet. Dabei wird das US-amerikanische Konzept der Gay-Affirmative Practice (GAP) als ein Ansatz zum Umgang mit Diversität in der professionellen Praxis daraufhin kritisch hinterfragt, inwieweit er zur unbeabsichtigten Reproduktion gesellschaftlicher Machtverhältnisse und Teilhabeverweigerungen beitragen und einzuordnen ist. Affirmativ meint hierbei, wörtlich, eine „bejahende“ – also anerkennende und wertschätzende – Praxis.
The zooarchaeological identification of a ‘Morisco’ community after the Christian conquest of Granada (Spain, early 16th century): sociocultural continuities and economic innovations
Authors: García-García Marcos , García-Contreras Guillermo , Alexander Michelle M. , Banerjea Rowena Y. , Pluskowski Aleks 
Published: March 2021

AbstractThis article presents the results of the zooarchaeological analysis of an assemblage dating to the second quarter of the 16th century that was discovered on the current university campus of Cartuja, on the outskirts of Granada (Andalusia, Spain). During the Middle Ages, this area was largely used for agricultural purposes, including as estates owned by high officials of the Nasrid dynasty, the last Islamicate polity in the Iberian Peninsula. The Castilian conquest of Granada in 1492 brought significant changes to the area, with the construction of a Carthusian monastery and the transformation of the surrounding landscape, including changes in property structures, different agrarian regimes and the demolition of pre-existing structures. Among these transformations was the filling up of a well with construction materials, and its further use as a rubbish dump. This fill yielded an interesting and unique zooarchaeological assemblage, the study of which is presented here. The results advance our understanding of changing patterns in animal consumption during the formative transition from the Middle Ages to the Early Modern period at the heart of the former Nasrid Kingdom of Granada, and indicate the continuity of some Andalusi consumption patterns along with specialised production and distribution systems of meat products that have no archaeological precedent in the region, suggesting that the bones were dumped by a possible ‘Morisco’ community (autochthonous Muslims forced to convert to Christianity in 1502).
Remarkable multicuspid teeth in a new elusive skate (Chondrichthyes, Rajiformes) from the Mediterranean Pliocene
Authors: Collareta Alberto , Mollen Frederik H. , Merella Marco , Casati Simone , Di Cencio Andrea 
Published: March 2021

AbstractHere we report on four highly peculiar skate teeth from Arcille and Certaldo, two Pliocene localities of Tuscany (central Italy). While being attributable to Rajiformes and somewhat reminiscent ofDipturusandRostroraja, these specimens display an unusual multicuspid tooth design that does not match any extinct or extant skate taxon known to date. The studied teeth are thus referred to a new genus and species of Rajiformes,Nebriimimus wardigen. et sp. nov., which is here tentatively assigned to the family Rajidae. Based on pronounced morphological similarities between the rather large-sized teeth of the latter and those of extant nurse sharks, we hypothesise thatN. wardimight have been capable of actively foraging upon relatively large food items compared to other rays. This extinct skate species was likely not a common component of the Pliocene Tuscan marine vertebrate assemblages. The palaeoenvironmental scenarios thatN. wardiinhabited were marginal-marine and open shelf settings characterised by tropical climate conditions. AsN. wardiis currently known only from lower to mid-Pliocene deposits of the Mediterranean Basin, it is tempting to speculate that its speciation dates back to an earliest Pliocene phase of diversification that also contributed to the emergence of the Mediterranean endemic stock of extant skate species.
Characterization of blood donors and non-blood donors in Germany using an online survey
Authors: Stock Benita , Möckel Luis 
Published: March 2021

Abstract
Objectives of this study were to analyze characteristics influencing blood donation status, to identify anxieties and reasons for (non-)blood donation, and potential channels for future blood donation campaigns. A random population from Germany was interviewed using the online survey tool SoSci Survey. The access link to the questionnaire was distributed via snowball system and the Bavarian Red Cross. Statistical analysis was performed to identify factors influencing blood donation status. A total of 682 participants (27.3% blood donors) with a mean age of 33.4 and a standard deviation (SD) of 12.0 years were included into the analysis. Strongest factor associated with being blood donor was having a blood donor within family and friends (Odds ratio [OR]: 5.05 [95% confidence interval [95% CI]: 2.63; 9.70]; p≤0.001), whereas having anxiety related to blood donation was the strongest factor for being non-blood donor (OR: 0.11 [95% CI: 0.05; 0.21] p≤0.001). Other factors significantly influencing blood donor status were age, health-related quality of life, knowledge on blood donation, being an organ donor and having pre-conditions. Main anxieties avoiding blood donation were fear of physical consequences, and fear of the injection needle. Most frequently mentioned channels which should be used for blood donation campaigns were Instagram and free TV. Involving blood donors into campaigns to recruit new blood donors from their personal environment and to focus campaign content on physical benefits of blood donations might help to recruit new blood donors. In addition, running campaigns stronger on channels such as Instagram might increase their scope.
Anticandidal Activity of Omiganan and Its Retro Analog Alone and in Combination with Fluconazole
Authors: Czechowicz Paulina , Jaśkiewicz Maciej , Neubauer Damian , Gościniak Grażyna , Kamysz Wojciech 
Published: March 2021

Abstract
Vulvovaginal candidiasis (VVC) is a vaginal infection that manifests itself as several symptoms which can lead to various life-threatening complications. The majority of VVC is caused by Candida albicans strains, and it is estimated that approximately 75% of women worldwide would suffer from this condition at least once during their lifetime. Surprisingly, the detailed pathomechanism of yeast-like fungi invasions in vagina is not yet fully understood. However, the ability to form biofilm on vaginal mucosa is considered as one of the critical factors associated with failure of the therapy and recurrences of the disease. Antimicrobial peptides (AMPs) are a promising class of compounds that are receiving a growing interest owing to their antibacterial, antifungal, and antibiofilm properties. Omiganan is a synthetic analog of Indolicidin that is characterized by wide spectrum of antimicrobial and antibiofilm activities. Recent reports suggest improved activity of analogs with a reversed sequence (retro-analog concept). Therefore, Omiganan and its retro analog were tested against planktonic forms and biofilm of 18 Candida strains isolated from VVC. Moreover, the synergy between the AMPs and fluconazole was studied as well. The AMPs appeared to be effective against C. albicans biofilm, and the reversion of the sequence generally led to an improved antimicrobial activity. Furthermore, confocal and scanning electron microscopic visualizations revealed the effectiveness of AMPs-fluconazole combinations also against fluconazole-resistant strains.

Graphical Abstract
Subgame Maxmin Strategies in Zero-Sum Stochastic Games with Tolerance Levels
Authors: Flesch János , Herings P. Jean-Jacques , Maes Jasmine , Predtetchinski Arkadi 
Published: March 2021

AbstractWe study subgame $$\phi $$
ϕ
-maxmin strategies in two-player zero-sum stochastic games with a countable state space, finite action spaces, and a bounded and universally measurable payoff function. Here, $$\phi $$
ϕ
denotes the tolerance function that assigns a nonnegative tolerated error level to every subgame. Subgame $$\phi $$
ϕ
-maxmin strategies are strategies of the maximizing player that guarantee the lower value in every subgame within the subgame-dependent tolerance level as given by $$\phi $$
ϕ
. First, we provide necessary and sufficient conditions for a strategy to be a subgame $$\phi $$
ϕ
-maxmin strategy. As a special case, we obtain a characterization for subgame maxmin strategies, i.e., strategies that exactly guarantee the lower value at every subgame. Secondly, we present sufficient conditions for the existence of a subgame $$\phi $$
ϕ
-maxmin strategy. Finally, we show the possibly surprising result that each game admits a strictly positive tolerance function $$\phi ^*$$

ϕ
∗

with the following property: if a player has a subgame $$\phi ^*$$

ϕ
∗

-maxmin strategy, then he has a subgame maxmin strategy too. As a consequence, the existence of a subgame $$\phi $$
ϕ
-maxmin strategy for every positive tolerance function $$\phi $$
ϕ
is equivalent to the existence of a subgame maxmin strategy.
An improved algorithm for phase-resolved sea surface reconstruction from X-band marine radar images
Authors: Zinchenko Victoria , Vasilyev Leonid , Halstensen Svein Olav , Liu Yuming 
Published: March 2021

AbstractWe present a modified methodology for phase-resolved surface wave reconstruction from incoherent X-band marine radar images. The method is based on the linear wave theory and uses the linear dispersion relation to extract the valuable signals associated with gravity waves. A parameter optimization of the proposed modification is performed based on simulated synthetic radar images. The quantitative comparisons in the accuracy of the standard and modified reconstruction methods are made for both simulated and real radar images. The correlation coefficient between reconstructed and true wave elevations is improved up to 0.9–0.92 for the present modified method from 0.69 to 0.74 for the standard method for the simulated sea surfaces. The wave spectra reconstructed from the real X-band radar measurements are in good agreement with those obtained from the independent point measurement by Miros RangeFinder for both unimodal and bimodal seas.
Inflation bald als Folgeeffekt der COVID-19-Pandemie?
Authors: Beretta Edoardo 
Published: March 2021

ZusammenfassungObwohl man im Zuge der COVID-19-Pandemie aufgrund des dramatischen Einbruchs aller Wirtschaftsprognosen weltweit bislang von rezessiv-deflationären Auswirkungen ausgegangen ist, lassen sich Inflationsrisiken keineswegs ausschließen. Welche Folgeeffekte kann die Kombination aus milliardenhohen Liquiditätsspritzen bei starkem Produktionsrückgang sowie streng einzuhaltenden (und ebenso kostenträchtigen) Sicherheits- und Schutzauflagen entfalten? Und wieso sollte aus makroökonomischer Sicht zwischen „Inflation“ und „steigenden Lebenshaltungskosten“ unterschieden werden? Im vorliegenden Beitrag wird mithilfe eines logisch-analytischen Denkansatzes auch argumentiert, wie sich derartige Inflationsszenarien wirtschaftspolitisch abwenden ließen. Denn eins ist genauso sicher: die Relation zwischen Naturkatastrophen und Inflation besteht seit je. Umso mehr, falls Inflationserscheinungen – wie heutzutage – nur zum Teil erkannt werden.
Comparison of User Satisfaction and Preference with Inhalant Devices Between a Pressurized Metered-Dose Inhaler and Ellipta in Stable Asthma Patients: A Randomized, Crossover Study
Authors: Ohbayashi Hiroyuki , Asano Takamitsu , Kudo Sahori , Ariga Mitsue 
Published: March 2021

Abstract
Introduction
Inhalation therapy involves two types of adherence: adherence to the drug and adherence to the procedures for the inhalation device. User satisfaction and preference are key factors for maintaining good adherence of both types, and they should be evaluated based on three conditions being well maintained: asthma control level (ACL), adherence, and adequate device operability during usage duration. We compared user satisfaction and preference between a pressurized metered-dose inhaler (pMDI) and a dry powder inhaler (Ellipta), while maintaining the three conditions during usage in stable asthma patients.

Methods
In this open-label, randomized, two-way crossover study, patients with stable asthma [Asthma Control Questionnaire (ACQ) scores < 0.75] were classified into a 20–64-year age group (G1) and a ≥ 65-year age group (G2) and randomly assigned to either a formoterol/fluticasone combination (FFC) as the pMDI group or a vilanterol/fluticasone combination (VFC) as the Ellipta group. Satisfaction and preference levels were evaluated at week 4. ACL was measured using the ACQ and Japan Asthma Control Survey questionnaires at weeks 0 and 4. Device operability and respiratory resistance were also examined.

Results
Forty-four patients (23 G1, age 45.8 ± 1.9 years; 21 G2, 74.1 ± 1.3 years) were enrolled and maintained good ACL during the study. Adherence to FFC pMDI and VFC Ellipta was > 97% in all groups. Device operability did not differ significantly between FFC pMDI and VFC Ellipta in the G1 (p = 0.189) or G2 (p = 0.506) group. Overall satisfaction was marginally higher with the FFC pMDI than with the VFC Ellipta in G2 (p = 0.012) but non-significantly different in G1 (p = 0.733). Factors affecting overall satisfaction in G2 were difference of inhalation device and body mass index. Respiratory resistance did not change significantly over the study in G2.

Conclusion
Based on maintaining good ACL, adherence, and device operability, FFC pMDI showed significantly higher satisfaction and preference levels than VFC Ellipta in elderly persons.

Trial Registration
Japan Registry of Clinical Trials identifier, jRCTs041180001 (registered 21 August 2018).
Analysis of hyperbolic Pennes bioheat equation in perfused homogeneous biological tissue subject to the instantaneous moving heat source
Authors: Kabiri Ali , Talaee Mohammad Reza 
Published: March 2021

AbstractThe one-dimensional hyperbolic Pennes bioheat equation under instantaneous moving heat source is solved analytically based on the Eigenvalue method. Comparison with results of in vivo experiments performed earlier by other authors shows the excellent prediction of the presented closed-form solution. We present three examples for calculating the Arrhenius equation to predict the tissue thermal damage analysis with our solution, i.e., characteristics of skin, liver, and kidney are modeled by using their thermophysical properties. Furthermore, the effects of moving velocity and perfusion rate on temperature profiles and thermal tissue damage are investigated. Results illustrate that the perfusion rate plays the cooling role in the heating source moving path. Also, increasing the moving velocity leads to a decrease in absorbed heat and temperature profiles. The closed-form analytical solution could be applied to verify the numerical heating model and optimize surgery planning parameters.
Reactive transport in porous media: a review of recent mathematical efforts in modeling geochemical reactions in petroleum subsurface reservoirs
Authors: Abd Abdul Salam , Abushaikha Ahmad S. 
Published: March 2021

AbstractThe rapid advancements in the computational abilities of numerical simulations have attracted researchers to work on the area of reactive transport in porous media to improve the hydrocarbon production processes from mature reservoirs. In the hydrology community, reactive transport is well developed where the main research focuses on studying the movement of groundwater and contaminants in aquifers, and quantifying the effect of chemical reactions between the rocks and water. Recently, great efforts have been made to adapt similar models for petroleum applications where multiphase flow is experienced in the subsurface reservoirs. In such systems, thermodynamic and chemical equilibrium is key in establishing an accurate description of the states of the fluids existing in the reservoir. This paper presents a detailed and comprehensive review on the concepts of geochemical modeling, and how it can be mathematically adapted to petroleum multiphase flow problems in porous media. We introduce key physical concepts outlining the treatment of chemical reactions in experimental trials and then explain in detail how a network of chemical reactions can be modeled mathematically for numerical simulation applications. The steps of characterizing the physical behavior of the fluid flow—through a set of governing equations by either natural or molar variables formulations, and the methodology to simplify and incorporate the numerical algorithms into an existing reservoir simulation scheme are shown as well. We finally present two numerical cases from the literature to highlight the key variations between the different variable formulations and comment on the advantages and disadvantages of each approach.
Nano-platinum additives ball milled with hollow carbon spheres for mechanical tensile promotion of 2212- Pb1+x(HCNs/Pt)xBiSr2CaCu2O8 superconductor
Authors: Elsabawy Khaled M. , Fallatah Ahmed M. , Owidah Zeid O. 
Published: March 2021

AbstractIn the present investigations platinum nano-particles in range of ≤ 20 nm were carefully ball milled with nominal composition of hollow carbon nano-spheres to apply as a softener ductile mechanical tensile promoter for 2212-PBSCCO superconductor. The samples with general formula Pb1+x(HCNs/Pt)xBiSr2CaCu2O8 where (x = 0.1,0.2 and 0.4 mol) were carefully synthesized via solid state reaction route with a certain thermal treatment cycle involving, annealing step at 865 °C for 20 h. The mechanical tensile strength measurements for the sample with x = 0.4 mol from CNs/Pt achieved maximum mechanical tensile strength value of 45.77 MPa., with promotion ratio ~ 21.08% in contrast with pure-sample x = 0 with mechanical tensile of 37.8 MPa. Furthermore, the additions of (HCNs/Pt) does not damage the whole superconductivity on the investigated range (0 ≤ x ≤ 0.4 mol). Results indicated that, the additions of (HCNs/Pt) had a remarkable, suppressing the Tc-values to Tc-offset = 62.2 K for the sample with maximum additive ratio x = 0.4 mol.