bluuebunny/crossref_metadata_2025_split huggingface dataset:
The utility of upper limb loading device in determining optimal walking ability in ambulatory individuals with spinal cord injury
Authors: Kumprou Makamas , Amatachaya Pipatana , Sooknuan Thanat , Arayawichanon Preeda , Thaweewannakij Thiwabhorn , Amatachaya Sugalya 
Published: January 2021

Background: Walking devices are frequently prescribed for many individuals, including those with spinal cord injury (SCI), to promote their independence. However, without proper screening and follow-up care, the individuals may continue using the same device when their conditions have progressed, that may possibly worsen their walking ability. Objective: This study developed an upper limb loading device (ULLD), and assessed the possibility of using the tool to determine the optimal walking ability of ambulatory participants with SCI who used a walking device daily ([Formula: see text]). Methods: All participants were assessed for their optimal walking ability, i.e., the ability of walking with the least support device or no device as they could do safely and confidently. The participants were also assessed for their amount of weight-bearing on the upper limbs or upper limb loading while walking, amount of weight-bearing on the lower limbs or lower limb loading while stepping of the other leg, and walking performance. Results: The findings indicated that approximately one third of the participants (31%) could progress their walking ability from their current ability, whereby four participants could even walk without a walking device. The amount of upper limb loading while walking, lower limb loading ability, and walking performance were significantly different among the groups of optimal walking ability ([Formula: see text]). Furthermore, the amount of upper limb loading showed negative correlation to the amount of lower limb loading and walking performance ([Formula: see text] to [Formula: see text]0.493, [Formula: see text]). Conclusion: The findings suggest the potential benefit of using the upper limb loading device and the amount of upper limb loading for walking device prescription, and monitoring the change of walking ability among ambulatory individuals with SCI.
The Discrepancy in Oxygen Evolution Reaction Catalyst Lifetime Explained: RDE vs MEA - Dynamicity within the Catalyst Layer Matters
Authors: Fathi Tovini Mohammad , Hartig-Weiß Alexandra , Gasteiger Hubert A. , El-Sayed Hany A. 
Published: January 2021

This study reveals the source of discrepancy between the lifetime of oxygen evolution reaction (OER) catalysts determined by rotating disk electrode (RDE) measurements vs that obtained in a membrane electrode assembly (MEA) in an electrolyzer. We show that the accumulation of microscopic oxygen bubbles in the pores of the electro-catalyst layer during the OER takes place in both RDE and MEA measurements. However, this accumulation was found to be much more significant in RDE measurements, where the shielding of almost all of the catalyst active sites by gas bubbles leads to rapid performance deterioration. This decrease in performance, albeit largely reversible, was found to also induce irreversible catalyst degradation, which could be avoided if the accumulation of microscopic bubbles is prevented. This type of artefact results in vastly under-estimated catalyst lifetimes obtained by RDE experiments, resulting in values that are orders of magnitude shorter than those obtained using MEA measurements, and a hypothesis for this discrepancy will be proposed. Therefore, electrochemical cells with liquid electrolytes are not reliable for OER catalyst lifetime determination.
This was paper 236 presented at the Atlanta, Georgia, Meeting of the Society, October 13–17, 2019.
Snow Particle Collection Efficiency and Adjustment Curves for the Hotplate Precipitation Gauge
Authors: Cauteruccio Arianna , Chinchella Enrico , Stagnaro Mattia , Lanza Luca G. 
Published: January 2021

AbstractThe hotplate precipitation gauge operates by means of a thermodynamic principle. It is composed of a small disk with two thin aluminum heated plates on the upper and lower faces. Each plate has three concentric rings to prevent the hydrometeors from sliding off in strong wind. As for the more widely used tipping-bucket and weighing gauges, measurements are affected by the wind-induced bias due to the bluff-body aerodynamics of the instrument outer shape. Unsteady Reynolds-averaged Navier–Stokes equations were numerically solved, using a k–ω shear stress transport closure model, to simulate the aerodynamic influence of the gauge body on the airflow. Wind tunnel tests were conducted to validate simulation results. Solid particle trajectories were modeled using a Lagrangian particle tracking model to evaluate the influence of the airflow modification on the ability of the instrument to collect the incoming hydrometeors. A suitable parameterization of the particle size distribution, as a function of the snowfall intensity, was employed to calculate the collection efficiency (CE) under different wind conditions. Results reveal a relevant role of the three rings in enhancing the collection performance of the gauge. Below 7.5 m s−1, the CE curves linearly decrease with increasing the wind speed, while beyond that threshold, the blocking caused by the rings counter effects the aerodynamic induced undercatch, and the CE curves quadratically increase with the wind speed. At high wind speed, the undercatch vanishes and the instrument exhibits a rapidly increasing overcatch. For operational purposes, adjustment curves were formulated as a function of the wind speed and the measured snowfall intensity.
Using faith-based organisations to promote mental health education to underserved populations in Jamaica
Authors: Pottinger Audrey M , Passard Nickiesha , Gordon Stair Angela 
Published: January 2021

Objective: The under-utilisation of mental health services by populations because of inadequate mental health education by community leaders and the public is of concern. The primary purpose of this study was to evaluate the usefulness of brief 1-day workshops in educating the public about mental health. Design: Quantitative pre–post evaluation. Setting: Community-based mental health workshops in urban Jamaica. Method: A survey on awareness of mental health resources was completed by 39 community leaders. In addition, 204 participants, who attended three 1-day public educational workshops, anonymously completed evaluations of workshop objectives including met expectations, stimulated learning, and workshop strengths and weaknesses. Of these participants, 157 completed pre–post workshop evaluations to identify subjective improvements in knowledge and competency. Results: Almost 60% of community leaders reported being in regular contact with persons who expressed poor emotional well-being, but typically only referred 25%–30% for mental health counselling. The workshops on mental health education, facilitated by faith-based organisations, were well subscribed by the public and most participants rated them favourably. Significantly more participants reported satisfaction with the workshops on Parenting Practices compared to Workplace Wellness ( p < .05). Wilcoxon Signed Rank tests revealed higher mean scores overall on post-workshop evaluation indicating gain in knowledge and competency; mean pre-test score, 3.26 (0.77), and post-test, 4.38 (0.48), p < .000. Conclusion: One-day mental health education workshops met public expectations and resulted in subjective gains in knowledge and competency. Research is needed to clarify the specific benefits of using public education workshops supported by faith-based organisations to promote mental health.
An intraneural ganglion cyst of the ulnar nerve at the wrist: a case report and literature review
Authors: Wang Gu Heng , Mao Tian , Chen Ya Lan , Xu Cheng , Xing Shu Guo , Ni Xue Jun , Deng Ai Dong 
Published: January 2021

Background Intraneural ganglion cysts of the ulnar nerve at the wrist are rare and poorly understood. We report a case of an intraneural ganglion cyst at the level of the wrist. Case presentation: A 48-year-old man presented with the complaints of weakness for 6 months and serious aggravation for 1 month in his right hand. After examinations, including ultrasound, the patient was diagnosed with an intraneural ganglion cyst. Intraoperatively, with exposure of the ulnar nerve, we found that the intraneural ganglion cyst was at the level of Guyon’s canal and extended approximately 6 cm proximally. Postoperatively, sensation of the fingers was normal, but atrophy of his muscles and limited straightening of his ring and little fingers were similar to those preoperatively. Conclusions Diagnosis of an intraneural cyst before surgery is mostly based on ultrasound and magnetic resonance imaging. Transection of the articular branch is an important measure to prevent recurrence of this cyst. If the ulnar nerve is compressed and causes symptoms, nerve decompression, including removal/aspiration of the cyst, and sometimes external neurolysis of the nerve, are necessary to relieve the symptoms and allow regeneration of the nerve. However, these should be performed without damaging the nerve fascicles.
Outpatient clinical pharmacy practice in the face of COVID-19 at a cancer center in New York City
Authors: Yerram Prakirthi , Thackray Jennifer , Modelevsky Lisa R , Land Josiah D , Reiss Samantha N , Spatz Krisoula H , Levoir Andrea C , Pak Terry K , Dao Phuong H , Buege Michael J , Derespiris Lauren M , Lau Carmen , Orozco Jennifer S , Boparai Manpreet , Koranteng Lauren A , Reichert Kate E , Yan Shirley Q , Daukshus Nicole P , Mathew Sherry , Buie Larry W , Tizon Richard F , Freeswick Scott , Liu Dazhi , Harnicar Stephen 
Published: January 2021

Purpose With the rapid spread of COVID-19 in New York City since early March 2020, innovative measures were needed for clinical pharmacy specialists to provide direct clinical care safely to cancer patients. Allocating the workforce was necessary to meet the surging needs of the inpatient services due to the COVID-19 outbreak, which had the potential to compromise outpatient services. We present here our approach of restructuring clinical pharmacy services and providing direct patient care in outpatient clinics during the pandemic. Data sources We conducted a retrospective review of electronic clinical documentation involving clinical pharmacy specialist patient encounters in 9 outpatient clinics from March 1, 2020 to May 31, 2020. The analysis of the clinical pharmacy specialist interventions and the impact of the interventions was descriptive. Data summary As hospital services were modified to handle the surge due to COVID-19, select clinical pharmacy specialists were redeployed from the outpatient clinics or research blocks to COVID-19 inpatient teams. During these 3 months, clinical pharmacy specialists were involved in 2535 patient visits from 9 outpatient clinics and contributed a total of 4022 interventions, the majority of which utilized telemedicine. The interventions provided critical clinical pharmacy care during the pandemic and omitted 199 in-person visits for medical care. Conclusion The swift transition to telemedicine allowed the provision of direct clinical pharmacy services to patients with cancer during the COVID-19 pandemic.
The effectiveness of internet-based telerehabilitation among patients after total joint arthroplasty: A systematic review and meta-analysis of randomised controlled trials
Authors: Wang Qingling , Lee Regina L-T , Hunter Sharyn , Chan Sally W-C 
Published: January 2021

Introduction The aim of this review was to systematically evaluate the available evidence on the effectiveness of internet-based telerehabilitation among patients after total joint arthroplasty regarding pain, range of motion, physical function, health-related quality of life, satisfaction, and psychological well-being. Methods This was a systematic review with meta-analysis based on the Cochrane Handbook for Systematic Reviews of Interventions guidelines. Studies published in English or Chinese were searched using defined search periods, databases, and search terms. Two reviewers assessed independently the quality of studies. RevMan 5.3 was used for meta-analysis. Heterogeneity was assessed using the χ2 and I2 statistic. A random effect model and mean difference (MD) with 95% confidence interval (CI) was adopted. Standardised mean difference (SMD) was used if the outcome was measured by different scales. Results Eleven studies with 1020 participants were analysed. Compared to face-to-face rehabilitation, internet-based telerehabilitation showed no significant difference in outcomes of pain (SMD–0.11, 95% CI–0.32 to 0.10), range of motion in flexion (MD 0.65, 95% CI–1.18 to 2.48) and extension (MD–0.38, 95% CI–1.16 to 0.40), patient-reported physical function (SMD 0.01, 95% CI–0.15 to 0.17), health-related quality of life (SMD–0.09, 95% CI–0.26 to 0.07), satisfaction (SMD–0.04, 95% CI–0.21 to 0.14), and psychological well-being (SMD 0.10, 95% CI–0.13 to 0.33). Internet-based telerehabilitation showed better outcomes in physical functional tests (SMD–0.54, 95% CI–1.08 to–0.01). Discussion This review suggests that internet-based telerehabilitation has comparable effectiveness to face-to-face rehabilitation on rehabilitation outcomes among patients after total joint arthroplasty.
Lymph Node Ratio Rather Than Positive Lymph Node Counts Has Better Prognostic Value in Patients With Testicular Germ Cell Tumors
Authors: Huang Chuyang , Long Qian , Pan Yangxun , Wu Leilei , Wang Xiaonan , Xu Hailin , Zheng Fufu 
Published: January 2021

Background: Testicular cancer represents the most common malignancy in young adult men. In the current study, we sought to analyze and compare the prognostic value of lymph node ratio (LNR) as well as positive lymph node counts (LNC) to understand its clinical significance in testicular germ cell tumors. Methods: We employed eligibility criteria to recruit a total of 931 patients, with testicular cancer, from 2010 to 2015 from The Surveillance, Epidemiology, and End Results (SEER) database. We then used the X-Tile program to calculate LNR and LNC cutoff values and discriminate survival. We then calculated the overall and cancer specific survival rates and analyzed the association between LNR/LNC and clinical pathological characteristics using the χ2 test. Finally, we assessed the relationships between clinical pathological factors and patient survival using univariate Cox proportional hazard analysis. Results: Univariate analysis revealed a significant association between prognosis with age (HR, 5.169; 95% CI, 1.758-15.200; P = 0.003), AJCC stage (III vs I: HR, 9.298; 95% CI, 2.691-32.131; P < 0.001), M stage (HR, 7.897; 95% CI, 3.417-18.251; P < 0.001) and LNR (HR, 3.009; 95% CI, 1.275-7.098; P = 0.012). On the other hand, LNC (HR, 1.743; 95% CI, 0.687-4.420; P = 0.242) was not significantly associated with prognosis. Analysis of the association between LNR/LNC and clinical pathological characteristics showed that high LNR patients tended to have significantly larger tumor sizes (χ2 = 7.877, P = 0.005), as well as advanced T (χ2 = 13.195, P = 0.004), N ( χ2 = 86.775, P < 0.001), M (χ2 = 19.948, P < 0.001) and 7th AJCC (χ2 = 103.074, P < 0.001) stages. In addition, high LNC patients were significantly associated with T (χ2 = 8.799, P = 0.032), N (χ2 = 74.390, P < 0.001) and 7th AJCC (χ2 = 111.759, P < 0.001) stages. Conclusion: LNR was a better predictor for long-term prognosis and was closely associated with clinical pathological characteristics than LNC in patients with testicular germ cell tumors.
Frequency and Significance of Maneuvers to Dissect the Distal Internal Carotid Artery During Carotid Endarterectomy
Authors: Kakkos Stavros K. , Papageorgopoulou Chrysanthi P. , Papadoulas Spyros , Nikolakopoulos Konstantinos M. , Kouri Anastasia , Salmas Marios , Siampalioti Athina , Zotou Anastasia , Ellul John , Tsolakis Ioannis 
Published: January 2021

Objectives: To describe the frequency, factors associated with, and significance of surgical dissection maneuvers of the distal internal carotid artery (ICA) during carotid endarterectomy (CEA). Methods: In this retrospective analysis of prospectively collected information in patients undergoing CEA, we recorded information on demographics, risk factors and comorbidities, dissection maneuvers of the distal ICA, other operative variables and neurological outcome measures. Results: During the period July 2008 and February 2020 inclusive, 218 consecutive patients (180 males, median age 69.5 years) underwent 240 CEAs. In 117 (48.8%) of them, CEA was performed for a symptomatic stenosis. Dissection maneuvers of the distal ICA were required in 77 cases (32.1%), including division and ligation of the sternocleidomastoid vessels in 66 cases (27.5%), mobilization of the XII cranial nerve in 69 cases (28.7%, with concomitant transection of the superior root of the ansa cervicalis in 11 cases, 4.6%) and division of the posterior belly of the digastric muscle in 8 cases (3.3%). Styloid osteotomy was not required in any case. Smoking was the single predictive factor associated with the use of an adjunctive dissection maneuver (odds ratio 2.23, p = 0.009). The use of a patch was more common in smokers (16% vs 7.1% in non-smokers, odds ratio 2.48, p = 0.05). Perioperative stroke and/or death rate was 0%, not allowing testing for associations with maneuver performance. Two patients (0.8%) developed a transient ischemic attack and 4 patients (1.7%) a cranial nerve injury (CNI), including 2 patients with recurrent laryngeal nerve palsy, diagnosed on routine laryngoscopy during planning of a contralateral CEA. There was no association between CNI and dissection of the distal ICA using an operative adjunct (p = 0.60). Conclusions: Several surgical maneuvers are often required to accomplish dissection of the distal ICA beyond the point of atherosclerotic disease. When dictated by operative findings, such maneuvers are deemed safe.
Management of esophageal strictures after endoscopic resection for early neoplasia
Authors: Abou Ali Einas , Belle Arthur , Hallit Rachel , Terris Benoit , Beuvon Frédéric , Leconte Mahaut , Dohan Anthony , Leblanc Sarah , Dermine Solène , Palmieri Lola-Jade , Coriat Romain , Chaussade Stanislas , Barret Maximilien 
Published: January 2021

Background: Endoscopic resection of extensive esophageal neoplastic lesions is associated with a high rate of esophageal stricture. Most studies have focused on the risk factors for post-endoscopic esophageal stricture, but data on the therapeutic management of these strictures are scarce. Our aim is to describe the management of esophageal strictures following endoscopic resection for early esophageal neoplasia. Methods: We included all patients with an endoscopic resection for early esophageal neoplasia followed by endoscopic dilatation at a tertiary referral center. We recorded the demographic, endoscopic, and histological characteristics, and the outcomes of the treatment of the strictures. Results: Between January 2010 and December 2019, we performed 166 endoscopic mucosal resections and 261 endoscopic submucosal dissections for early esophageal neoplasia, and 34 (8.0%) patients developed an esophageal stricture requiring endoscopic treatment. The indication for endoscopic resection was Barrett’s neoplasia in 15/34 (44.1%) cases and squamous cell neoplasia (SCN) in 19/34 (55.9%) cases. The median [(interquartile range) (IQR)] number of endoscopic dilatations was 2.5 (2.0–4.0). Nine of 34 (26.5%) patients required only one dilatation, and 22/34 (65%) had complete dysphagia relief following three endoscopic treatment sessions. The median number of dilatations was significantly higher for SCN [3.0 (2–7); range 1–17; p = 0.02], and in the case of circumferential resection [4.0 (3.0–7.0); p = 0.03]. Endoscopic dilatation allowed a sustained dysphagia relief in 33/34 (97.0%) patients after a mean follow-up of 25.3 ± 22 months. Conclusion: Refractory post-endoscopic esophageal stricture is a rare event. After a median of 2.5 endoscopic dilatations, 97.0% of patients were permanently relieved of dysphagia. Circumferential endoscopic esophageal resections should be considered when indicated.
DeepLPI: a multimodal deep learning method for predicting the interactions between lncRNAs and protein isoforms
Authors: Shaw Dipan , Chen Hao , Xie Minzhu , Jiang Tao 
Published: January 2021

Abstract
Background
Long non-coding RNAs (lncRNAs) regulate diverse biological processes via interactions with proteins. Since the experimental methods to identify these interactions are expensive and time-consuming, many computational methods have been proposed. Although these computational methods have achieved promising prediction performance, they neglect the fact that a gene may encode multiple protein isoforms and different isoforms of the same gene may interact differently with the same lncRNA.

Results
In this study, we propose a novel method, DeepLPI, for predicting the interactions between lncRNAs and protein isoforms. Our method uses sequence and structure data to extract intrinsic features and expression data to extract topological features. To combine these different data, we adopt a hybrid framework by integrating a multimodal deep learning neural network and a conditional random field. To overcome the lack of known interactions between lncRNAs and protein isoforms, we apply a multiple instance learning (MIL) approach. In our experiment concerning the human lncRNA-protein interactions in the NPInter v3.0 database, DeepLPI improved the prediction performance by 4.7% in term of AUC and 5.9% in term of AUPRC over the state-of-the-art methods. Our further correlation analyses between interactive lncRNAs and protein isoforms also illustrated that their co-expression information helped predict the interactions. Finally, we give some examples where DeepLPI was able to outperform the other methods in predicting mouse lncRNA-protein interactions and novel human lncRNA-protein interactions.

Conclusion
Our results demonstrated that the use of isoforms and MIL contributed significantly to the improvement of performance in predicting lncRNA and protein interactions. We believe that such an approach would find more applications in predicting other functional roles of RNAs and proteins.