bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced giant dielectric properties and improved nonlinear electrical response in acceptor-donor (Al3+, Ta5+)-substituted CaCu3Ti4O12 ceramics
Authors: Boonlakhorn Jakkree , Chanlek Narong , Manyam Jedsada , Srepusharawoot Pornjuk , Krongsuk Sriprajak , Thongbai Prasit 
Published: July 2021

AbstractThe giant dielectric behavior of CaCu3Ti4O12 (CCTO) has been widely investigated owing to its potential applications in electronics; however, the loss tangent (tanδ) of this material is too large for many applications. A partial substitution of CCTO ceramics with either Al3+ or Ta5+ ions generally results in poorer nonlinear properties and an associated increase in tanδ (to ~0.29–1.15). However, first-principles calculations showed that self-charge compensation occurs between these two dopant ions when co-doped into Ti4+ sites, which can improve the electrical properties of the grain boundary (GB). Surprisingly, in this study, a greatly enhanced breakdown electric field (~200–6588 V/cm) and nonlinear coefficient (~4.8–15.2) with a significantly reduced tanδ (~0.010–0.036) were obtained by simultaneous partial substitution of CCTO with acceptor-donor (Al3+, Ta5+) dopants to produce (Al3+, Ta5+)-CCTO ceramics. The reduced tanδ and improved nonlinear properties were attributed to the synergistic effects of the co-dopants in the doped CCTO structure. The significant reduction in the mean grain size of the (Al3+, Ta5+)-CCTO ceramics compared to pure CCTO was mainly because of the Ta5+ ions. Accordingly, the increased GB density due to the reduced grain size and the larger Schottky barrier height (Φb) at the GBs of the co-doped CCTO ceramics were the main reasons for the greatly increased GB resistance, improved nonlinear properties, and reduced tanδ values compared to pure and single-doped CCTO. In addition, high dielectric constant values (ε′ ≈ (0.52–2.7) × 104) were obtained. A fine-grained microstructure with highly insulating GBs was obtained by Ta5+ doping, while co-doping with Ta5+ and Al3+ resulted in a high Φb. The obtained results are expected to provide useful guidelines for developing new giant dielectric ceramics with excellent dielectric properties.
Safer Tripping: Serotonergic Psychedelics and Drug Checking. Submission and Detection Rates, Potential Harms, and Challenges for Drug Analysis
Authors: Hirschfeld Tim , Smit-Rigter Laura , van der Gouwe Daan , Reiche Simon , Stöver Heino , Majić Tomislav 
Published: July 2021

AbstractPurpose of ReviewWith the continuous emergence of new psychoactive substances, drug checking (DC) services are challenged by an increasingly complex drug market. Considering the resumed scientific and public interest in serotonergic psychedelics (SPs) like LSD, psilocybin, and 2C-B, we present the results of a literature search investigating the presence and proportion of SPs in DC samples.Recent FindingsIn 15 identified reports, submission and detection rates of SPs were comparably low, but increasing. Samples contained considerable amounts of adulterations or analogues, mostly novel SPs with unknown toxicological profiles and in some cases potentially life-threatening effects. The detection of SPs, however, requires advanced analysis techniques currently not available to most DC services.SummaryGiven the substantial proportion of novel SPs in DC samples and the associated risks, DC can be a valuable harm reduction and monitoring tool for SPs if analysis techniques with high sensitivity are employed.
Sexual selection as race making
Authors: Sheldon Myrna Perez 
Published: July 2021

AbstractCharles Darwin's theory of sexual selection, as described inThe Descent of Man, and Selection in Relation to Sex(1871), should be viewed as a significant transitional point in the modern expression of race. Unlike earlier race theorists, Darwin proposed that sexual reproduction was not merely a testing ground of racial character, but was itself a causal force that could create new races. His account of race was distinctly modern – viewing race not in terms of blood but as a collection of population-level characteristics. Recognizing this feature of Darwin's sexual-selection theory allows us to situate Darwin's work not solely within the history of evolutionary science, but also within the structures of racism that became the governing principles of modern nation states. In other words, sexual selection is an expression of Michel Foucault's biopolitics, in which political power is exercised by states not through the contracts of liberal governance but through the management of population-level phenomena. Furthermore, by contextualizing sexual selection in this theoretical framework, it becomes possible to more clearly emphasize the importance of race in the rise of modern biopolitics.
On the Epistemic Costs of Friendship: Against the Encroachment View
Authors: Rioux Catherine 
Published: July 2021

AbstractI defend the thesis that friendship can constitutively require epistemic irrationality against a recent, forceful challenge, raised by proponents of moral and pragmatic encroachment. Defenders of the “encroachment strategy” argue that exemplary friends who are especially slow to believe that their friends have acted wrongly are simply sensitive to the high prudential or moral costs of falsely believing in their friends’ guilt. Drawing on psychological work on epistemic motivation (and in particular on the notion of “need for closure”), I propose a different picture of what friendship requires in the doxastic realm. I argue that contrary to what the encroachment strategy suggests, exemplary friends’ belief formation ought not be guided by a concern with accuracy or error avoidance, but instead by a need to avoid a “specific closure” – namely, a need to avoid concluding in their friends’ guilt. I propose that exemplary friendship often generates a defeasible, doxastic obligation to exemplify such a need, despite its inherent corrupting effects on exemplary friends’ epistemic faculties.
Rethinking the Value of Author Contribution Statements in Light of How Research Teams Respond to Retractions
Authors: Andersen Line Edslev , Wray K. Brad 
Published: July 2021

AbstractThe authorship policies of scientific journals often assume that in order to be able to properly place credit and responsibility for the content of a collaborative paper we should be able to distinguish the contributions of the various individuals involved. Hence, many journals have introduced a requirement for author contribution statements aimed at making it easier to place credit and responsibility on individual scientists. We argue that from a purely descriptive point of view the practices of collaborating scientists are at odds with the requirement for author contribution statements. We also argue that from a normative point of view the authorship policies may be unnecessary. Our arguments draw on an examination of 35 years of retraction notices in the journal Science.
Forgiveness and the Repairing of Epistemic Trust
Authors: Green Adam 
Published: July 2021

AbstractThe epistemic relevance of forgiveness has been neglected by both the discussion of forgiveness in moral psychology and by social epistemology generally. Moral psychology fails to account for the forgiveness of epistemic wrongs and for the way that wrongs in general have epistemic implications. Social epistemology, for its part, neglects the way that epistemic trust is not only conferred but repaired. In this essay, I show that the repair of epistemic trust through forgiveness is necessary to the economy of knowledge for fallible persons like us. Despite the fact that forgiveness is never included on lists of important intellectual virtues or epistemic activities, it is vital to our lives as social knowers. Likewise, an account of forgiveness that neglects its epistemic dimension is importantly incomplete.
Ordering results for smallest claim amounts from two portfolios of risks with dependent heterogeneous exponentiated location-scale claims
Authors: Das Sangita , Kayal Suchandan , Balakrishnan N. 
Published: July 2021

AbstractLet $\{Y_{1},\ldots ,Y_{n}\}$ be a collection of interdependent nonnegative random variables, with $Y_{i}$ having an exponentiated location-scale model with location parameter $\mu _i$, scale parameter $\delta _i$ and shape (skewness) parameter $\beta _i$, for $i\in \mathbb {I}_{n}=\{1,\ldots ,n\}$. Furthermore, let $\{L_1^{*},\ldots ,L_n^{*}\}$ be a set of independent Bernoulli random variables, independently of $Y_{i}$'s, with $E(L_{i}^{*})=p_{i}^{*}$, for $i\in \mathbb {I}_{n}.$ Under this setup, the portfolio of risks is the collection $\{T_{1}^{*}=L_{1}^{*}Y_{1},\ldots ,T_{n}^{*}=L_{n}^{*}Y_{n}\}$, wherein $T_{i}^{*}=L_{i}^{*}Y_{i}$ represents the $i$th claim amount. This article then presents several sufficient conditions, under which the smallest claim amounts are compared in terms of the usual stochastic and hazard rate orders. The comparison results are obtained when the dependence structure among the claim severities are modeled by (i) an Archimedean survival copula and (ii) a general survival copula. Several examples are also presented to illustrate the established results.
Multiple Cognitive and Behavioral Factors Link Association Between Brain Structure and Functional Impairment of Daily Instrumental Activities in Older Adults
Authors: Kwak Seyul , Park Su Mi , Jeon Yeong-Ju , Ko Hyunwoong , Oh Dae Jong , Lee Jun-Young 
Published: July 2021

AbstractObjective:Functional impairment in daily activity is a cornerstone in distinguishing the clinical progression of dementia. Multiple indicators based on neuroimaging and neuropsychological instruments are used to assess the levels of impairment and disease severity; however, it remains unclear how multivariate patterns of predictors uniquely predict the functional ability and how the relative importance of various predictors differs.Method:In this study, 881 older adults with subjective cognitive complaints, mild cognitive impairment (MCI), and dementia with Alzheimer’s type completed brain structural magnetic resonance imaging (MRI), neuropsychological assessment, and a survey of instrumental activities of daily living (IADL). We utilized the partial least square (PLS) method to identify latent components that are predictive of IADL.Results:The result showed distinct brain components (gray matter density of cerebellar, medial temporal, subcortical, limbic, and default network regions) and cognitive–behavioral components (general cognitive abilities, processing speed, and executive function, episodic memory, and neuropsychiatric symptoms) were predictive of IADL. Subsequent path analysis showed that the effect of brain structural components on IADL was largely mediated by cognitive and behavioral components. When comparing hierarchical regression models, the brain structural measures minimally added the explanatory power of cognitive and behavioral measures on IADL.Conclusion:Our finding suggests that cerebellar structure and orbitofrontal cortex, alongside with medial temporal lobe, play an important role in the maintenance of functional status in older adults with or without dementia. Moreover, the significance of brain structural volume affects real-life functional activities via disruptions in multiple cognitive and behavioral functions.
Making Sense of the Arbitrator's Ruling in DS 316, EC and Certain Member States – Measures Affecting Trade in Large Civil Aircraft (Article 22.6-EC): A Jigsaw Puzzle with (at Least) a Couple Missing Pieces
Authors: Mavroidis Petros C. , Saggi Kamal 
Published: July 2021

Abstract‘The US won a $7.5 Billion award from the World Trade Organization against the European Union, who has for many years treated the USA very badly on Trade due to Tariffs, Trade Barriers, and more. This case going on for years, a nice victory’, tweeted President Trump on 3 October 2019. The United States (US) won not only the highest amount of retaliation ever adjudicated in the history of the WTO but also an ongoing right to retaliate on an annual basis until such time as the EU had complied by either removing the subsidies it granted Airbus or somehow neutralizing their adverse effects on Boeing. In light of the facts of the case, this ruling has two major shortcomings. First, in sharp contrast with the statutory language and practice until now, the Arbitrator effectively introduced a permanent liability rule into the WTO system through the backdoor. Second, given the way the decision and the associated award has been written, it is simply impossible for the EU to comply because (a) the contested subsidies are no longer in existence and (b) no guidance has been provided on how the EU might go about removing their adverse effects on Boeing if it sought to achieve compliance. Thus, in all likelihood, the EU is saddled with a ruling that obligates it to cough up an annual sum of $7.5 billion USD for an indefinite time period.
Placental insufficiency induces a sexually dimorphic response in the expression of cardiac growth and metabolic signalling molecules upon exposure to a postnatal western diet in guinea pigs
Authors: Darby Jack R.T. , Chiu Jacky , Regnault Timothy R.H. , Morrison Janna L. 
Published: July 2021

AbstractThere is a strong relationship between low birth weight (LBW) and an increased risk of developing cardiovascular disease (CVD). In postnatal life, LBW offspring are becoming more commonly exposed to the additional independent CVD risk factors, such as an obesogenic diet. However, how an already detrimentally programmed LBW myocardium responds to a secondary insult, such as an obesogenic diet (western diet; WD), during postnatal life is ill defined. Herein, we aimed to determine in a pre-clinical guinea pig model of CVD, both the independent and interactive effects of LBW and a postnatal WD on the molecular pathways that regulate cardiac growth and metabolism. Uterine artery ablation was used to induce placental insufficiency (PI) in pregnant guinea pigs to generate LBW offspring. Normal birth weight (NBW) and LBW offspring were weaned onto either a Control diet or WD. At ˜145 days after birth (young adulthood), male and female offspring were humanely killed, the heart weighed and left ventricle tissue collected. The mRNA expression of signalling molecules involved in a pathological hypertrophic and fibrotic response was increased in the myocardium of LBW male, but not female offspring, fed a WD as was the mRNA expression of transcription factors involved in fatty acid oxidation. The mRNA expression of glucose transporters was downregulated by LBW and WD in male, but not female hearts. This study has highlighted a sexually dimorphic cardiac pathological hypertrophic and fibrotic response to the secondary insult of postnatal WD consumption in LBW offspring.
Vietnam's Military and Political Challenges in Cambodia and the Early Rise of Cambodia's Strongman, Hun Sen, 1977–79
Authors: Path Kosal , Nhem Boraden 
Published: July 2021

AbstractMuch has been written about Cambodia's strongman, Prime Minister Hun Sen, who has been in power since 1985. Yet, the history of Hun Sen's early rise to a position of power in the Vietnam-initiated Cambodian revolution after June 1977 remains murky. Relying on Vietnamese and Cambodian archival documents, memoirs and interviews with former veterans of Unit 125 as well as Hun Sen's speeches and personal recollection of his historic journey to Vietnam on 20 June 1977, we make a two-fold argument. First, Hanoi's decision to establish an anti-Pol Pot Cambodian revolution in southern Vietnam to take over Cambodia—after toppling Democratic Kampuchea—was part of Hanoi's strategic plan to handle a double challenge: (1) to avoid being branded as an invader and (2) to establish a capable and friendly regime in Cambodia after the war. This provided an opportunity for a young Khmer Rouge defector, Hun Sen, to change his fortune by quickly earning the Vietnamese military leadership's trust and confidence based on his competence to organize and command the first army unit of the new Cambodian revolution, i.e. Unit 125. Second, as lucky as he was to flee across the heavily militarized border into Vietnam unharmed, Hun Sen's early rise to power is attributed to his survivalist instinct combined with shrewd strategic thinking.
Recent Trends in SST, Chl‐a, Productivity and Wind Stress in Upwelling and Open Ocean Areas in the Upper Eastern North Atlantic Subtropical Gyre
Authors: Siemer J. P. , Machín F. , González‐Vega A. , Arrieta J. M. , Gutiérrez‐Guerra M. A. , Pérez‐Hernández M. D. , Vélez‐Belchí P. , Hernández‐Guerra A. , Fraile‐Nuez E. 
Published: July 2021

AbstractThe global upper ocean has been warming during the last decades accompanied with a chlorophyll‐a (Chl‐a) and productivity decrease. Whereas subtropical gyres show similar trends, Eastern Boundary Upwelling Systems are thought to increase in productivity due to increased trade winds. This study analyzes recent trends in sea surface temperature (SST), Chl‐a, net primary production (NPP) and meridional wind stress in the Eastern North Atlantic subtropical gyre (NASE) in order to examine if the global trends can be detected in open ocean and upwelling areas and how the ocean biota responds. Satellite data of such variables of the last 15–40 years were analyzed to calculate mean trends in upwelling areas in the Canary upwelling system and open ocean areas around the Azores, Madeira and the Canary Islands. Our results show significant warming in the area with a maximum of 2.7°C per century for the Azores. Moreover, a general decreasing trend for Chl‐a and NPP seems to be more evident in the permanent upwelling areas, which will be responsible for a loss of 0.13% of the global NPP per century. Our results also highlight a significant expansion of the oceanic desert area of 10% with an increase in unproductive days of up to 84 days in the last 20 years. The competitive relationship of stratification and wind stress in the Canary upwelling system might be a more plausible explanation for the decrease in Chl‐a and NPP in upwelling areas linked to the increase in upwelling favorable wind stress and the surface warming.
Quantifying the effects of hydrogen on carbon assimilation in a seafloor microbial community associated with ultramafic rocks
Authors: Coskun Ömer K , Vuillemin Aurèle , Schubotz Florence , Klein Frieder , Sichel Susanna E , Eisenreich Wolfgang , Orsi William D 
Published: July 2021

Abstract
Thermodynamic models predict that H2 is energetically favorable for seafloor microbial life, but how H2 affects anabolic processes in seafloor-associated communities is poorly understood. Here, we used quantitative 13C DNA stable isotope probing (qSIP) to quantify the effect of H2 on carbon assimilation by microbial taxa synthesizing 13C-labeled DNA that are associated with partially serpentinized peridotite rocks from the equatorial Mid-Atlantic Ridge. The rock-hosted seafloor community was an order of magnitude more diverse compared to the seawater community directly above the rocks. With added H2, peridotite-associated taxa increased assimilation of 13C-bicarbonate and 13C-acetate into 16S rRNA genes of operational taxonomic units by 146% (±29%) and 55% (±34%), respectively, which correlated with enrichment of H2-oxidizing NiFe-hydrogenases encoded in peridotite-associated metagenomes. The effect of H2 on anabolism was phylogenetically organized, with taxa affiliated with Atribacteria, Nitrospira, and Thaumarchaeota exhibiting the most significant increases in 13C-substrate assimilation in the presence of H2. In SIP incubations with added H2, an order of magnitude higher number of peridotite rock-associated taxa assimilated 13C-bicarbonate, 13C-acetate, and 13C-formate compared to taxa that were not associated with peridotites. Collectively, these findings indicate that the unique geochemical nature of the peridotite-hosted ecosystem has selected for H2-metabolizing, rock-associated taxa that can increase anabolism under high H2 concentrations. Because ultramafic rocks are widespread in slow-, and ultraslow-spreading oceanic lithosphere, continental margins, and subduction zones where H2 is formed in copious amounts, the link between H2 and carbon assimilation demonstrated here may be widespread within these geological settings.
Distinct motivations to seek out information in healthy individuals and problem gamblers
Authors: Dezza Irene Cogliati , Noel Xavier , Cleeremans Axel , Yu Angela J. 
Published: July 2021

AbstractAs massive amounts of information are becoming available to people, understanding the mechanisms underlying information-seeking is more pertinent today than ever. In this study, we investigate the underlying motivations to seek out information in healthy and addicted individuals. We developed a novel decision-making task and a novel computational model which allows dissociating the relative contribution of two motivating factors to seek out information: a desire for novelty and a general desire for knowledge. To investigate whether/how the motivations to seek out information vary between healthy and addicted individuals, in addition to healthy controls we included a sample of individuals with gambling disorder—a form of addiction without the confound of substance consumption and characterized by compulsive gambling. Our results indicate that healthy subjects and problem gamblers adopt distinct information-seeking “modes”. Healthy information-seeking behavior was mostly motivated by a desire for novelty. Problem gamblers, on the contrary, displayed reduced novelty-seeking and an increased desire for accumulating knowledge compared to healthy controls. Our findings not only shed new light on the motivations driving healthy and addicted individuals to seek out information, but they also have important implications for the treatment and diagnosis of behavioral addiction.
BH3-only protein expression determines hepatocellular carcinoma response to sorafenib-based treatment
Authors: Busche Stephanie , John Katharina , Wandrer Franziska , Vondran Florian W. R. , Lehmann Ulrich , Wedemeyer Heiner , Essmann Frank , Schulze-Osthoff Klaus , Bantel Heike 
Published: July 2021

AbstractHepatocellular carcinoma (HCC) represents a global health challenge with limited therapeutic options. Anti-angiogenic immune checkpoint inhibitor-based combination therapy has been introduced for progressed HCC, but improves survival only in a subset of HCC patients. Tyrosine-kinase inhibitors (TKI) such as sorafenib represent an alternative treatment option but have only modest efficacy. Using different HCC cell lines and HCC tissues from various patients reflecting HCC heterogeneity, we investigated whether the sorafenib response could be enhanced by combination with pro-apoptotic agents, such as TNF-related apoptosis-inducing ligand (TRAIL) or the BH3-mimetic ABT-737, which target the death receptor and mitochondrial pathway of apoptosis, respectively. We found that both agents could enhance sorafenib-induced cell death which was, however, dependent on specific BH3-only proteins. TRAIL augmented sorafenib-induced cell death only in NOXA-expressing HCC cells, whereas ABT-737 enhanced the sorafenib response also in NOXA-deficient cells. ABT-737, however, failed to augment sorafenib cytotoxicity in the absence of BIM, even when NOXA was strongly expressed. In the presence of NOXA, BIM-deficient HCC cells could be in turn strongly sensitized for cell death induction by the combination of sorafenib with TRAIL. Accordingly, HCC tissues sensitive to apoptosis induction by sorafenib and TRAIL revealed enhanced NOXA expression compared to HCC tissues resistant to this treatment combination. Thus, our results suggest that BH3-only protein expression determines the treatment response of HCC to different sorafenib-based drug combinations. Individual profiling of BH3-only protein expression might therefore assist patient stratification to certain TKI-based HCC therapies.