bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH PEMBERIAN SEDIAAN MIKROEMULSI EKSTRAK DAUN KENIKIR (Cosmos caudatus) TERHADAP PENURUNAN KADAR ASAM URAT TIKUS YANG DI INDUKSI HATI AYAM
Authors: Yusuf Muhammad , Jaluri Poppy Dwi Citra , Irawan Yogie 
Published: November 2021

Hiperurisemia adalah keadaan dimana terjadi peningkatan kadar asam urat dalam darah diatas normal. Tanaman kenikir (Cosmos caudatus) merupakan tanaman yang banyak dijumpai di lingkungan sekitar, serta tanaman yang sudah tidak asing lagi dan telah banyak dikonsumsi sebagai sayuran. Salah satu kandungan dalam kenikir adalah senyawa golongan flavonoid. Pada penelitian ini mikroemulsi ekstrak kenikir digunakan untuk menurunkan kadar asam urat pada tikus yang diinduksi hati ayam. Mikroemulsi dibuat dengan menggunakan virgin coconut oil (VCO) sebagai fase minyak, Tween 80 dan Span 80 sebagai surfaktan dan gliserin sebagai kosurfaktan. Penelitian menggunakan 15 ekor tikus putih jantan galur wistar yang diinduksi jus hati ayam. Tikus dibagi menjadi 3 kelompok, yaitu kelompok kontrol negatif mikroemulsi placebo, kontrol positif mikroemulsi Allopurinol 3,6 mg/200 g BB tikus, serta kelompok perlakuan mikroemulsi daun kenikir 10 mg/200 g BB tikus yang diberikan secara peroral. Pengukuran kadar asam urat dilakukan pada hari ke-0 (kadar awal), hari ke-7 (kadar setelah induksi) dan hari ke-13(kadar setelah perlakuan). Persen penurunan kadar asam urat dalam darah dianalisis secara statistika dengan taraf kepercayaan 95%. Hasil uji statistika menyatakan ada perbedaan antara kelompok kontrol negatif dan positif dengan kelompok perlakuan mikroemulsi daun kenikir memiliki nilai signifikansi 0,000. Sehingga mikroemulsi daun kenikir dapat menurunkan kadar urisemia tikus yang diinduksi ekstrak hati ayam namun memiliki kemampuan yang tidak sebaik mikroemulsi allopurinol. Kata Kunci : Mikroemulsi, Kenikir (Cosmos Caudatus), Hiperurisemia, Ekstrak Hati Ayam, Allopurinol.
PENGARUH PEMBERIAN KOMBIASI IKAN GABUS DAN PUTIH TELUR TERHADAP KESEMBUHAN PASIEN LUKA POST OPERASI LAPARATOMI
Authors: Ningtyas Ni Wayan Rahayu , Fadillah Syahri , Syahleman Rukmini 
Published: November 2021

Pembedahan merupakan tindakan pengobatan invasif melalui sayatan untuk membuka atau menampilkan bagian tubuh yang akan ditangani dan diakhiri dengan penutupan dan penjahitan luka. Jenis luka yang dihasilkan dari tindakan bedah lapratomi. Tindakan pembedahan menempati urutan ke-11 dari 50 pola penyakit di Indonesia dengan presentase 12,8%. Tindakan bedah laparotomi yaitu luka operasi bersih terkontaminasi yang membutuhkan proses penyembuhan yang lebih lama. Proses penyembuhan luka ini memerlukan protein sebagai dasar terbentuknya jaringan kolagen, sedangkan komponen penting dari protein adalah albumin. Albumin dapat digunakan sebagai prediksi terbaik penyembuhan pasien. Albumin merupakan suplemen makanan yang juga terbentuk dari Putih Telur dan Ekstra Ophicephalus Striatus (Ikan Gabus).Tujuan penelitian ini adalah mengetahui pengaruh pemberian kombinasi ikan gabus dan putih telur terhadap kesembuhan pasien luka post operasi laparatomi di Ruang Meranti RSUD Sultan Imanuddin Pangkalan Bun.Metode penelitian : merupakan penelitian experiment dengan rancangan Quasy Experiment dengan jenis rancangan Nonequivalent Control Group Design.Hasil : analisis data menggunakan uji wilcoxon signed rank test, dari 38 responden yang diberikan konsumsi kombinasi dari ikan gabus dan putih telur mulai hari ke - 1 sampai hari ke – 5 didapatkan nilai signifikan p : 0,000; yang artinya terdapat pengaruh kombinasi pemberian ikan gabus dan putih telur terhadap kesembuhan luka post operasi laparatomi. Kata Kunci:Kombinasi Ikan Gabus dan Putih Telur, kesembuhan luka Laparatomi
TINGKAT KEPUASAN PASIEN TERHADAP PELAYANAN KEFARMASIAN DI PUSKESMAS MADUREJO DAN PUSKESMAS MENDAWAI KECAMATAN ARUT SELATAN KABUPATEN KOTAWARINGIN BARAT
Authors: A.P Muhammad Hafizh , Irawan Yogie , Irawan Ahmad 
Published: November 2021

Kepuasan adalah perasaan seseorang yang muncul setelah membandingkan kinerja yang diperkirakan dan kinerja yang diharapkan. Maka dari itu tingkat kepuasan yang diperoleh pelanggan berkaitan pada kualitas jasa yang mereka dapat. Tujuan penelitian untuk mengetahui tingkat kepuasan pasien terhadap pelayanan kefarmasian di Puskesmas Madurejo dan Puskesmas Mendawai Kecamatan Arut Selatan Kabupaten Kotawaringin Barat. Penelitian ini menggunakan desain penelitian bersifat deskriptif, teknik pengambilan sampel teknik purposive sampling. Sampel penelitian sebanyak 186 responden dari Puskesmas Madurejo dan Puskesmas Mendawai. Pengambilan data dilakukan melalui pengisian kuesioner yang telah di uji validitas dan realibilitasnya serta waktu tunggu yang dilakukan dengan menggunakan stopwatch. Hasil penelitian menunjukan bahwa tingkat kepuasan persentase rata – rata secara keseluruhan sebesar (94,90%) pada Puskesmas Madurejo dan (95,63) Pada Puskesmas Mendawai dengan kategori kepuasan adalah sangat puas. Hasil penelitian tentang waktu tunggu pelayanan resep memiliki rata – rata waktu tunggu resep racikan 10 menit pada kedua Puskesmas, sedangkan waktu tunggu resep obat non racikan adalah 3 menit Puskesmas Madurejo dan 5 Menit Puskesmas Mendawai. berdasarkan hasil penelitian diperoleh bahwa tingkat kepuasan pasien terhadap pelayanan kefarmasian di Puskesmas Madurejo dan Puskesmas Mendawai dalam kategori sangat puas. Kata Kunci: Tingkat kepuasan, Waktu Tunggu, Kefarmasian, Deskriptif.
Potassium in Solid Cancers
Authors: Iorio Jessica , Lastraioli Lisa , Lastraioli Elena 
Published: November 2021

Electrolyte disorders are a frequent finding in cancer patients. In the majority of cases the etiologies of such disorders are common to all cancer types (i.e. diuretic-induced hyponatremia or hypokalemia). Sometimes, electrolyte disorders are caused by paraneoplastic syndromes or are due to cancer therapy. Potassium is one of the most important electrolytes of the human body since it is involved in the regulation of muscle contraction, maintenance of the integrity of the skeleton, blood pressure and nerve transmission as well as in the normal function of cells. Potassium homeostasis is strictly regulated since the gap between the recommended daily dietary intake (120 mEq/day) and the levels stored in the extracellular fluid (around 70 mEq) is huge. Alterations of potassium homeostasis are frequent in cancer patients as well alterations in potassium channels, the transmembrane proteins that mediate potassium fluxes within the cells. The present chapter is focused on the clinical significance of potassium homeostasis and potassium channels in patients with solid tumors.
Body Mass Index and Melanoma Prognosis
Authors: Cassano Nicoletta , Caccavale Stefano , Vena Gino A. , Argenziano Giuseppe 
Published: November 2021

Introduction: Obesity has been suggested as a risk factor in the progression of malignancies, including melanoma. Most studies defined obesity using body mass index (BMI), although the index is considered an imperfect measure of body composition.
Objective: The aim of this article is to examine whether BMI can impact the prognosis of cutaneous melanoma, regardless of anti-tumor therapy. The relationship between BMI and specific prognostic factors in melanoma patients has been reviewed.
Methods: Literature search was conducted on PubMed using the terms “melanoma” and “body mass index” or “obesity”. We selected articles, published up to 30 November 2020, examining the prognostic aspects of melanoma. Articles evaluating the risk and incidence of melanoma were excluded as well as studies regarding morbidity and complications following surgical procedures, or those performed in metastatic melanoma patients treated with anti-tumor therapies.
Results: Mixed results have emerged from studies assessing the clinical outcomes in melanoma patients in relation to BMI. More consistent data seem to support the relationship between BMI and Breslow thickness.
Conclusions: Studies that focus specifically on the link between obesity and melanoma prognosis are limited; further research is needed to deepen our knowledge on this link.
Between two worlds: Cova Eirós and the Middle-Upper Palaeolithic transition in NW Iberia
Authors: LOMBERA-HERMIDA Arturo de , RODRÍGUEZ-ÁLVAREZ Xose-Pedro , IGLESIAS Alicia AMEIJENDA , RODRÍGUEZ Mikel DÍAZ , Iván REY-RODRÍGUEZ undefined , TEJEDOR Irene VALVERDE , PÉREZ-ALBERTI Augusto , CUNHA Pedro P. , GARCÍA Hugo BAL , MOREIRA Xes ALDEA , SALGUEIRO Cristian LORENZO , CASTRO Tania MOSQUERA , VALCARCE Ramón FÁBREGAS 
Published: November 2021

Iberia, a natural cul-de-sac peninsula, plays a major role in the study of the Neanderthals demise and its eventual relationship with the spread of Anatomically Modern Humans (AMH) in Europe. The site of Cova Eirós (Galicia, Spain), located in NW Iberia, contains Middle and Upper Palaeolithic levels, based on the cultural remains recovered at the site. No human remains directly associated with those levels were discovered yet. The available radiocarbon dates from the levels 2 (c. 35 ka cal BP, Early Upper Paleolithic) and 3 (c. 41 ka cal BP, Late Middle Paleolithic), point to a late survival of Neanderthal groups in North Iberia and to a relative quick arrival of the AMH, c. 35-36 ka cal BP, with respect to other territories of the Iberian Peninsula. The archaeological record shows clear differences between the Middle and the Upper Palaeolithic occupations, regarding raw-material acquisition, lithic technology and subsistence strategies. The location of Cova Eirós in the westernmost margin of the Cantabrian Rim and in the Atlantic Façade, makes this site a key place to understand the spread of the first AMH and the progressive demise of Neanderthal populations.
Design, Synthesis and Antibacterial Activity of some 3,6-Dimethlyquinoxaline-2-Hydrazone Derivatives
Authors: Taiwo F. O. , Obafemi C. A. , Akinpelu D. A. , Iyiola T. O. 
Published: November 2021

Aims: This aims of this study was to continue the effort to synthesis new quinoxaline-based heterocycles and study its antibacterial properties.
Objective: This study was designed to reacts 3,6-dimethylquinoxaline-2-hydrazine with some substituted aromatic ketones and study their antibacterial properties on some locally and clinically isolated bacterial strains.
Materials and Methods: Five 3,6-dimethylquinoxaline-2-hydrazone derivatives were synthesized from the reactions of 3,6-dimethylquinoxaline-2-hydrazine with various substituted aromatic ketones. The products were then tested for their potential antibacterial properties.
Results: All the synthesized compounds were found to be active against all the bacterial strains investigated in this study. It was observed that the zones of inhibition observed for the synthesized compounds against the test organisms ranged between 15 mm and 38 mm. The MIC observed for the synthesized compounds ranged between 0.0313mg/mL and 0.125 mg/mL, while that of the standard antibiotic, streptomycin, varied between 0.0313 mg/mL and 0.500 mg/mL and those observed for tetracycline falls between 0.0313 mg/mL and 0.500 mg/mL. The minimum bactericidal concentrations exhibited by the synthesized compounds ranged between 0.0625 mg/mL and 0.250 mg/mL
Discussion and conclusion: The study concluded that all the compounds exhibited appreciable bactericidal effects against all the bacterial strains, which is an indication that such synthetic compounds possessed broad spectrum activities and such compounds could be useful in formulation of antibacterial compounds which could be used to mitigates infections caused by pathogens that are now developing resistance against the available antibiotics.
An Evaluation of Visual Perception Visual Memory Cognitive Functions and Emotional Status among Genders in Elderly Subjects
Authors: Ruhina A. , Sridevi G. 
Published: November 2021

Background: Gender differences in visual memory and perception and cognitive test performance have been significantly influenced by factors like sex
Objective: The current study aimed to evaluate the gender differences in patterns of cognitive test performance and visual perception in healthy elderly individuals.
Methods: Cognitive functions and visual perception was analyzed using clock drawing test and picture identification test in 20 elderly men and women (10 each) and their emotional status was assessed using depression scale
Results: The results revealed that females had a better visual memory and depth perception compared to men and the value was statistically significant at p<0.05. Females performed better than men on tests of Picture identification and were better in phonemic verbal skills compared to male men and the value was statistically significant at p<0.05
Conclusion: The present study concluded an innovative finding that women were better in their performance related to visual depth perception and cognitive functions.
MIKC
C
‐type MADS‐box Transcription Factors in Tomato Reproductive Development: An Overview of Their Role in Meristems, Flower, Fruit, and Flower Abscission Zone Development
Authors: Boumlik Rachid , Bendahmane Abdelhafid , Roldan Maria Victoria Gomez 
Published: November 2021

Abstract

MADS‐box transcription factors (TFs) play key roles in cellular and developmental processes in organisms ranging from yeast to humans and can be divided into type I and type II. Type II MADS‐box TFs are further classed into two subgroups MIKC
C
and MIKC*. In plants, MIKC
C
‐type TFs are well known for their role in the ABCDE model for floral organ identity specification in the model plant
Arabidopsis
and other flowering plant species. However, with the exception of
Arabidopsis
, very little is known about the function of these TFs in developmental processes in other flowering plant species. MIKC
C
‐type TFs have been reported as crucial regulators of flower organ identity, inflorescence architecture, flower abscission zone development and fruit maturation in the model plant tomato (
Solanum lycopersicum
). Here, we discuss current knowledge of MIKC
C
‐type TFs in tomato and provide detailed overview of their roles in reproductive developmental processes based on the available functional genetic, transcriptomic, protein–protein and protein–DNA interaction data.
Laser‐Directed Foaming of Hydroplastic Polyelectrolyte Films toward Tunable Structures and Programmable Routes
Authors: Zhang Da , Li Qing‐Shuang , Liang Zi‐Xuan , Chen Xia‐Chao , Hao Junran , Yao Juming , Lu Chun‐Xin , Zhou Yahong , Jiang Lei 
Published: November 2021

AbstractAlthough many methods have been developed to create porous structures within polyelectrolyte films, it remains a challenge to conveniently define the spatial distribution of these structures. Herein, a simple, universal strategy with a high flexibility in programming porous regions throughout polyelectrolyte films is reported. This strategy is performed with the aid of laser scanning and the emergence of porous regions precisely tails after the moving path of laser beams. Quite different from previous strategies, the pore‐forming mechanism relies on laser‐triggered generation of gas to foam the films, which can be regulated by the content of photo‐sensitive groups, the intensity of laser beams, and the supramolecular interactions between polyelectrolyte chains. A prerequisite to succeed the foaming of polyelectrolyte films is to irradiate them under water, where the mobility of polyelectrolytes is activated to accommodate the pore formation within the films. Although many pore‐forming mechanisms involve aqueous systems, the porous structures here can be well preserved during drying procedures, which is hardly realized for conventional methods due to the formation of capillary pressure. The resulting polyelectrolyte films with patterned porosity can be quite useful in many fields, including but not limited to information display, surface wettability, and cell behavior manipulation.
Cu12Sb4S13 Quantum Dots/Few‐Layered Ti3C2 Nanosheets with Enhanced K+ Diffusion Dynamics for Efficient Potassium Ion Storage
Authors: Cao Yaping , Zhang Yelong , Chen Hui , Qin Shengyu , Zhang Lanying , Guo Shaojun , Yang Huai 
Published: November 2021

AbstractDespite the high theoretical specific capacity of transition‐metal disulfides anode for potassium‐ion batteries (PIBs), their development has been greatly hindered by dramatic capacity fading and poor cycle life. Herein, the synthesis of the new composite of Cu12Sb4S13 quantum dots/few‐layered Ti3C2 nanosheets (CAS‐Ti3C2) as advanced anode for boosting the K ion storage is reported. It is found that as‐made CAS‐Ti3C2 show a strong synergistic effect between quantum dots and Ti3C2 nanosheets mainly caused by the formation of the Ti–S bond, which can not only shorten the diffusion path of K+ but also accommodate the serious volumetric variation during the discharge/charge process. As expected, this specially designed CAS‐Ti3C2 anode exhibits a superior reversible specific capacity of 496.7 mAh g−1 at 100 mA g−1 after 200 cycles and 175.6 mAh g−1 at a high current density of 1.0 A g−1 even over 1800 cycles, preceding most of the reported transition‐metal disulfides quantum dots‐based anodes for PIBs. These comprehensive studies reveal that the excellent electrochemical property is attributed to the fast K+ diffusion kinetics and unique transformation and restorage mechanism between K+ with CAS‐Ti3C2 anode.
Lateral Flow Glyco‐Assays for the Rapid and Low‐Cost Detection of Lectins–Polymeric Linkers and Particle Engineering Are Essential for Selectivity and Performance
Authors: Baker Alexander N. , Muguruza Asier R. , Richards Sarah‐Jane , Georgiou Panagiotis G. , Goetz Stephen , Walker Marc , Dedola Simone , Field Robert A. , Gibson Matthew I. 
Published: November 2021

AbstractLateral flow immuno‐assays, such as the home pregnancy test, are rapid point‐of‐care diagnostics that use antibody‐coated nanoparticles to bind antigens/analytes (e.g., viruses, toxins or hormones). Ease of use, no need for centralized infrastructure and low‐cost, makes these devices appealing for rapid disease identification, especially in low‐resource environments. Here glycosylated polymer‐coated nanoparticles are demonstrated for the sensitive, label‐free detection of lectins in lateral flow and flow‐through. The systems introduced here use glycans, not antibodies, to provide recognition: a “lateral flow glyco‐assay,” providing unique biosensing opportunities. Glycans are installed onto polymer termini and immobilized onto gold nanoparticles, providing colloidal stability but crucially also introducing assay tunability and selectivity. Using soybean agglutinin and Ricinus communis agglutinin I (RCA120) as model analytes, the impact of polymer chain length and nanoparticle core size are evaluated, with chain length found to have a significant effect on signal generation—highlighting the need to control the macromolecular architecture to tune response. With optimized systems, lectins are detectable at subnanomolar concentrations, comparable to antibody‐based systems. Complete lateral flow devices are also assembled to show how these devices can be deployed in the “real world.” This work shows that glycan‐binding can be a valuable tool in rapid diagnostics.
Boosting Electric Double Layer Capacitance in Laser‐Induced Graphene‐Based Supercapacitors
Authors: Reina Marco , Scalia Alberto , Auxilia Giorgio , Fontana Marco , Bella Federico , Ferrero Sergio , Lamberti Andrea 
Published: November 2021

AbstractLaser‐induced graphene (LIG) is under the spotlight as a promising material for flexible supercapacitors due to its simple processing and flexibility. However, the poor conductivity and the reduced surface area have prompted research to improve its performance, traditionally introducing a pseudocapacitive behavior. Herein an effective yet easy way is presented to dramatically improve the electric double layer capacitance of LIG electrodes for supercapacitor‐related applications without the occurrence of redox reactions. The strategy simply relies on the exploitation of an LIG network to trap and interconnect activated carbon (AC) particles. In order to optimize the infiltration of AC into LIG porosities, several strategies are tested, both varying the surface wettability of LIG and acting on the impregnation approach. Overall, the best compromise results in the combination of LIG N‐doping by nitric acid incubation with vacuum‐assisted infiltration of an AC‐slurry, allowing a two‐order of magnitude improvement in the specific capacitance up to 20 mF cm−2 in device configuration.
A Localized Planarization Strategy in Hole Mobility Modulation of Disordered Triphenylamine‐Based Organic Semiconductors
Authors: Zhang Zewei , Zhu Yanan , Wu Yuting , Zhao Chongguang , Meng Hong 
Published: November 2021

AbstractHole mobility plays a critical role in organic semiconductors, which is synergistically controlled by many factors closely interrelated to the molecular configuration, for example, the degree of molecular planarization. But at present, analysis from quantitative ab initio models to assess this correlation is lacking. Here, a series of triphenylamine‐based materials are designed and investigated to build a system with different levels of planarization. The key parameters in the Marcus equation are calculated with quantum and molecular mechanics methods and the hole mobilities are evaluated. Compared with non‐planar and fully planar molecules, localized planar molecules exhibit low reorganization energy, high transfer integral, and moderate energy disorder. Considering the conjugation and rigidity effects, a localized planarization strategy is demonstrated to design functional triphenylamine‐based materials by keeping a balance of the three factors above and enhanced hole mobilities are predicted. This strategy will shed light on mobility optimization and the applications of triphenylamine‐based materials.
Graphdiyne‐Induced Iron Vacancy for Efficient Nitrogen Conversion
Authors: Fang Yan , Xue Yurui , Hui Lan , Yu Huidi , Zhang Chao , Huang Bolong , Li Yuliang 
Published: November 2021

AbstractAn iron vacancy‐rich ferroferric oxide/graphdiyne heterostructure (IVR‐FO/GDY) is rationally designed and fabricated for high‐efficiency electrocatalytic nitrogen fixation to ammonia (ENFA). Experimental and theoretical results show that the GDY‐induced iron vacancies in IVR‐FO/GDY promote the electrocatalysis, and activate the local O sites to transfer electrons towards GDY to boost ENFA, resulting in promising electrocatalytic performances with a highest ammonia yield (YNH3) of 134.02 µg h−1 mgcat.−1 and Faradaic efficiency (FE) of up to 60.88%, as well as the high long‐term stability in neutral electrolytes. The cationic vacancy activation strategy proposed in this work has strong general and universal guiding significance to the design of new efficient electrocatalysts for various electrochemical energy conversion reactions. Such defect engineering may be used efficiently in electrocatalysis, leading to the development and progress of energy industry.