bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ni-Based CW6MC: Effect of the Internal Revert Recycle on the Soundness of the Alloy
Authors: Gruttadauria Andrea , Barella Silvia , Guerra Anna 
Published: April 2021

AbstractThe CW6MC alloy is a nickel-based alloy used to withstand acidic environments, especially in the oil and gas industry where it is used in the production of valves, impellers, and pipes. This alloy is the foundry counterpart of the best known A625 for plastic deformation. Regarding nickel-based alloys, a scrap market like that in the case of steel has not yet been established, therefore, especially in the case of foundries, scrap generally comes from internal recycling (casting waste, feeders, sprues, runners, etc.) to be certain of the origin and quality of the material. In this work, four castings with different percentage of recycled content (0%, 30%, 70%, 100%) were produced in accordance with the technical specifications and analysed to evaluate the effect of scrap on the final chemical composition, the microstructure, the mechanical properties and corrosion resistance. Following the analyses carried out, it was determined that the amount of acceptable scrap content (of those analysed) without compromising the material properties corresponds to 30%.
O-Töne in Fernsehnachrichten im Spannungsfeld von Narration und Argumentation
Authors: Luginbühl Martin 
Published: April 2021

ZusammenfassungDer Beitrag erläutert – vor dem Hintergrund des re-konstruktiven Charakters medialer Berichterstattung (Abschnitt 1) – das Konzept der ›News Narratives‹ (2). Dann wird auf die Rolle und bisherigen Untersuchungen von O‑Tönen und deren narrative Integration eingegangen (3). Auf Erläuterungen zu Fragestellung, Korpus und Methode (4) folgen quantitative und dann ausführlicher exemplarische qualitative Analysen (5). Hier werden Beiträge der Schweizer »Tagesschau« und der amerikanischen »CBS Evening News« seit den 1960er-Jahren analysiert. Es zeigt sich, dass die Beiträge zunehmend narrativ in einem engeren Sinn gestaltet werden, dass diese Entwicklung in den USA früher stattgefunden hat und dass die argumentative Funktionalisierung von O‑Tönen rekonstruiert werden kann, aber implizit bleibt.
Von Gutmenschen, guten Menschen und geflüchteten Menschen
Authors: Raters Marie-Luise 
Published: April 2021

ZusammenfassungViele Menschen erwarten Dankbarkeit von den Geflüchteten, die in Europa aufgenommen werden. Nun kann mit dem Satz „Geflüchtete sollen dankbar sein“ eine moralische Pflicht oder ein Ratschlag gemeint sein. Mein Essay zeigt in einem ersten Schritt, dass es keine Pflicht zur Dankbarkeit geben kann. Dankbarkeit ist vielmehr Supererogation, nämlich eine moralisch wertvolle Handlungsweise, die keine Pflicht sein kann. Das gilt auch für Geflüchtete. Anschließend zeige ich, dass Dankbarkeit als sympathischer Ausdruck einer Tugendhaltung jedermann anzuraten ist. Wer sich für erwiesene Wohltaten dankbar zeigt, wird gemocht und geschätzt. Das gilt wiederum auch für Geflüchtete. Mein Essay schließt mit einem kurzen Ausblick zu der Frage, wofür und in welchem Umfang Geflüchteten Dankbarkeit anzuraten ist.
Note on the Rhaetian fish fauna from a subrosion pipe in Winterswijk (the Netherlands), with a discussion on the validity of the genus Severnichthys Storrs, 1994
Authors: Diependaal Henk J. , Reumer Jelle W.F. 
Published: April 2021

Abstract
Fossil remains of fishes found in Rhaetian (Late Triassic, c.208.5–201.3 Ma) sediments collected from a subrosion pipe in the Winterswijk quarry are described. The fauna shows great similarity to material known from the British Triassic of the Penarth Group and from other localities in Northwestern Europe. Both chondrichthyan and osteichthyan teeth and scales are present. Most abundant are the sharks Lissodus minimus and Rhomphaiodon minor and the actinopterygians Gyrolepis albertii, Saurichthys longidens and Birgeria acuminata. Isolated teeth of the latter two taxa were known under the name Severnichthys acuminatus, but the genus Severnichthys is here considered a nomen dubium; it should be suppressed in order to make the taxonomy less complicated.
The Structure of Political Choices: Distinguishing Between Constraint and Multidimensionality
Authors: Marble William , Tyler Matthew 
Published: April 2021

AbstractIn the literatures on public opinion and legislative behavior, there are debates over (1) how constrained preferences are and (2) whether they are captured by a single left–right spectrum or require multiple dimensions. But insufficient formalization has led scholars to equate a lack of constraint with multidimensional preferences. In this paper, we refine the concepts of constraint and dimensionality in a formal framework and describe how they translate into separate observable implications for political preferences. We use this discussion to motivate a cross-validation estimator that measures constraint and dimensionality in the context of canonical ideal point models. Using data from the public and politicians, we find that American political preferences are one-dimensional, but there is more constraint among politicians than among the mass public. Furthermore, we show that differences between politicians and the public are not explained by differences in agendas or the incentives faced by the actors.
Intercontinental transmission and local demographic expansion of SARS-CoV-2
Authors: Hu Hong-yin , Yan Fang , Zhu Jia-ming , Karuno Alex Plimo , Zhou Wei-wei 
Published: April 2021

Abstract
The global outbreak of coronavirus disease 2019 (COVID-19) is greatly threatening the public health in the world. We reconstructed global transmissions and potential demographic expansions of severe acute respiratory syndrome coronavirus 2 based on genomic information. We found that intercontinental transmissions were rare in January and early February but drastically increased since late February. After world-wide implements of travel restrictions, the transmission frequencies decreased to a low level in April. We identified a total of 88 potential demographic expansions over the world based on the star-radiative networks and 75 of them were found in Europe and North America. The expansion numbers peaked in March and quickly dropped since April. These findings are highly concordant with epidemic reports and modelling results and highlight the significance of quarantine validity on the global spread of COVID-19. Our analyses indicate that the travel restrictions and social distancing measures are effective in containing the spread of COVID-19.
High-order and tunable balanced bandpass filters using mixed technology resonators
Authors: Simpson Dakotah , Psychogiou Dimitra 
Published: April 2021

AbstractThis paper reports on high-order balanced bandpass filters (BPFs) that are continuously tunable in terms of frequency and bandwidth and can be intrinsically switched-off. They use a hybrid integration scheme based on two different types of capacitively loaded resonators—ceramic coaxial and microstrip—that reduce the filter size, enhance its out-of-band selectivity and common-mode suppression, and allow for multiple levels of transfer function tuning. High selectivity is obtained in the differential mode due to the high number of poles and transmission zeros present. The common mode is highly suppressed through the introduction of additional transmission zeros and resistively loaded resonators. Furthermore, the use of ceramic coaxial resonators results in supplementary transmission zeros that are used to lower the out-of-band transmission in the differential mode. Multiple levels of tuning are obtained by reconfiguring only the frequency of the BPF's resonators. For experimental validation, a tunable mixed-technology microstrip prototype was manufactured and measured at S-band. It exhibited frequency tuning between 2.22 and 2.94 GHz, bandwidth tuning between 104 and 268 MHz, and an intrinsically switched-off mode with isolation >50 dB in the differential mode. For all states, the common mode was suppressed by at least 35 dB at the center frequency and within a wide range.
Refugees to the Rescue? Motivating Pro-Refugee Public Engagement During the COVID-19 Pandemic
Authors: Adida Claire L. , Lo Adeline , Prather Lauren , Williamson Scott 
Published: April 2021

AbstractMigrants are often scapegoated during public health crises. Can such crises create opportunities for migrant inclusion instead? As the COVID-19 pandemic unfolds, many refugee organizations have stepped up their outreach with stories of refugees helping out in the crisis. We have partnered with the country’s leading refugee advocate organizations to test whether solidarity narratives increase public engagement with refugee advocates. We employ a Facebook experimental design to evaluate the effectiveness of refugee narratives. We test whether (1) migrant narratives framed in the context of COVID-19, (2) COVID-19 migrant narratives targeted to more or less local communities, and (3) COVID-19 migrant narratives labeled as refugee vs. immigrant efforts enhance public engagement with refugee organizations. Our results indicate that migrant narratives framed in the context of COVID-19 do not motivate greater engagement than those that make no mention of the pandemic. Our results provide suggestive evidence that locally targeted efforts motivate greater engagement. Finally, we find no difference between the “refugee” and “immigrant” label, but we show that both labels can motivate greater engagement than ads that include neither. Importantly, this is true even in the context of COVID-19, an uncertain environment where worries of backlash might be warranted. These results suggest promising strategies for migrant policy organizations to promote engagement during and possibly after the pandemic.
Distribution, Source, and Burial of Sedimentary Organic Carbon in Kermadec and Atacama Trenches
Authors: Xu Yunping , Li Xinxin , Luo Min , Xiao Wenjie , Fang Jiasong , Rashid Harunur , Peng Yongbo , Li Wenpeng , Wenzhöfer Frank , Rowden Ashley A. , Glud Ronnie N. 
Published: April 2021

AbstractKnowledge of sedimentary organic carbon (OC) in hadal trenches, the deepest ocean realm, is rudimentary. Here, we conducted a comprehensive analysis of total OC (TOC), stable and radio‐carbon isotopes (δ13C and Δ14C), and biomarkers (e.g., n‐alkanes, n‐alkanols and n‐fatty acids) in 12 sediment cores collected from hadal (trench axis) and non‐hadal (abyssal plains and slopes) settings of the Kermadec Trench (Southwestern Pacific) and Atacama Trench (Southeastern Pacific) regions. Our results show that the TOC in the Atacama Trench region (0.86% ± 0.69%) is significantly higher than that of the Kermadec Trench region (0.29% ± 0.08%), likely related to different surface primary productivity. In both trench regions, the hadal sites are generally characterized by more negative δ13C, higher TOC/TN ratio, and similar or higher abundance ratio of terrigenous/marine biomarkers as compared to the non‐hadal sites, suggesting the selective preservation of terrigenous biogenic/fossil OC at the hadal trench axis. The linear increase in 14C age with sediment depth in non‐hadal cores reflects steady depositional conditions, whereas seven out of eight hadal sediment cores show 14C age reversals presumably due to occasional mass‐transport deposits. Our results suggest (1) a strong heterogeneity in sedimentary OC characteristics between trenches and within each trench and (2) relatively high accumulation rates of terrigenous OC in both the Kermadec Trench (0.35 ± 0.04 g m−2 yr−1) and the Atacama Trench (1.4 ± 0.5 g m−2 yr−1). Thus, hadal trenches appear to represent an important environment for terrigenous carbon deposition in the deep ocean.
Semi‐Analytical Modeling of Rate‐Dependent Relative Permeability in Heterogeneous Formations
Authors: Moreno Ziv , Anto‐Darkwah Evans , Rabinovich Avinoam 
Published: April 2021

AbstractRelative permeability (kr) is an important property characterizing multi‐phase flow in porous media, in particular considering applications of oil and gas production or CO2 storage in subsurface formations. Coreflooding experiments are the most common method of determining kr, usually conducted at a given total injection rate. However, kr is known to be a rate dependent effective property due to capillary heterogeneity effects and therefore full characterization requires conducting experiments at different flow rates, a complex and time consuming process. This work presents a new approach for calculating rate dependent effective kr curves based on a 1D semi‐analytical solution for steady state flow. The method entails calibrating a 1D permeability structure to represent the 3D flow of coreflooding experiments. Then, the calibrated 1D model is used to estimate kr curves at varying rates. We apply the method to three cases, two synthetic and one based on experimental data. Results show applicability for a wide range of flow rates.
A systematic review of neuroimaging and acute cannabis exposure in age-of-risk for psychosis
Authors: Cupo Lani , Plitman Eric , Guma Elisa , Chakravarty M. Mallar 
Published: April 2021

AbstractAcute exposure to cannabis has been associated with an array of cognitive alterations, increased risk for neuropsychiatric illness, and other neuropsychiatric sequelae including the emergence of acute psychotic symptoms. However, the brain alterations associating cannabis use and these behavioral and clinical phenotypes remains disputed. To this end, neuroimaging can be a powerful technique to non-invasively study the impact of cannabis exposure on brain structure and function in both humans and animal models. While chronic exposure studies provide insight into how use may be related to long-term outcomes, acute exposure may reveal interesting information regarding the immediate impact of use and abuse on brain circuits. Understanding these alterations could reveal the connection with symptom dimensions in neuropsychiatric disorders and, more specifically with psychosis. The purpose of the present review is to: 1) provide an update on the findings of pharmacological neuroimaging studies examining the effects of administered cannabinoids and 2) focus the discussion on studies that examine the sensitive window for the emergence of psychosis. Current literature indicates that cannabis exposure has varied effects on the brain, with the principal compounds in cannabis (delta-9-tetrahydrocannabinol and cannabidiol) altering activity across different brain regions. Importantly, we also discovered critical gaps in the literature, particularly regarding sex-dependent responses and long-term effects of chronic exposure. Certain networks often characterized as dysregulated in psychosis, like the default mode network and limbic system, were also impacted by THC exposure, identifying areas of particular interest for future work investigating the potential relationship between the two.
Determining lines of therapy in patients with solid cancers: a proposed new systematic and comprehensive framework
Authors: Saini Kamal S. , Twelves Chris 
Published: April 2021

AbstractThe complexity of neoplasia and its treatment are a challenge to the formulation of general criteria that are applicable across solid cancers. Determining the number of prior lines of therapy (LoT) is critically important for optimising future treatment, conducting medication audits, and assessing eligibility for clinical trial enrolment. Currently, however, no accepted set of criteria or definitions exists to enumerate LoT. In this article, we seek to open a dialogue to address this challenge by proposing a systematic and comprehensive framework to determine LoT uniformly across solid malignancies. First, key terms, including LoT and ‘clinical progression of disease’ are defined. Next, we clarify which therapies should be assigned a LoT, and why. Finally, we propose reporting LoT in a novel and standardised format as LoT N (CLoT + PLoT), where CLoT is the number of systemic anti-cancer therapies (SACT) administered with curative intent and/or in the early setting, PLoT is the number of SACT given with palliative intent and/or in the advanced setting, and N is the sum of CLoT and PLoT. As a next step, the cancer research community should develop and adopt standardised guidelines for enumerating LoT in a uniform manner.
Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids
Authors: Kim Chang H. 
Published: April 2021

AbstractA mounting body of evidence indicates that dietary fiber (DF) metabolites produced by commensal bacteria play essential roles in balancing the immune system. DF, considered nonessential nutrients in the past, is now considered to be necessary to maintain adequate levels of immunity and suppress inflammatory and allergic responses. Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, are the major DF metabolites and mostly produced by specialized commensal bacteria that are capable of breaking down DF into simpler saccharides and further metabolizing the saccharides into SCFAs. SCFAs act on many cell types to regulate a number of important biological processes, including host metabolism, intestinal functions, and immunity system. This review specifically highlights the regulatory functions of DF and SCFAs in the immune system with a focus on major innate and adaptive lymphocytes. Current information regarding how SCFAs regulate innate lymphoid cells, T helper cells, cytotoxic T cells, and B cells and how these functions impact immunity, inflammation, and allergic responses are discussed.
An update on the regulatory mechanisms of NLRP3 inflammasome activation
Authors: Paik Seungwha , Kim Jin Kyung , Silwal Prashanta , Sasakawa Chihiro , Jo Eun-Kyeong 
Published: April 2021

AbstractThe NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is a multiprotein complex involved in the release of mature interleukin-1β and triggering of pyroptosis, which is of paramount importance in a variety of physiological and pathological conditions. Over the past decade, considerable advances have been made in elucidating the molecular mechanisms underlying the priming/licensing (Signal 1) and assembly (Signal 2) involved in NLRP3 inflammasome activation. Recently, a number of studies have indicated that the priming/licensing step is regulated by complicated mechanisms at both the transcriptional and posttranslational levels. In this review, we discuss the current understanding of the mechanistic details of NLRP3 inflammasome activation with a particular emphasis on protein-protein interactions, posttranslational modifications, and spatiotemporal regulation of the NLRP3 inflammasome machinery. We also present a detailed summary of multiple positive and/or negative regulatory pathways providing upstream signals that culminate in NLRP3 inflammasome complex assembly. A better understanding of the molecular mechanisms underlying NLRP3 inflammasome activation will provide opportunities for the development of methods for the prevention and treatment of NLRP3 inflammasome-related diseases.
CARAMBA: a first-in-human clinical trial with SLAMF7 CAR-T cells prepared by virus-free Sleeping Beauty gene transfer to treat multiple myeloma
Authors: Prommersberger Sabrina , Reiser Michael , Beckmann Julia , Danhof Sophia , Amberger Maximilian , Quade-Lyssy Patricia , Einsele Hermann , Hudecek Michael , Bonig Halvard , Ivics Zoltán 
Published: April 2021

AbstractClinical development of chimeric antigen receptor (CAR)-T-cell therapy has been enabled by advances in synthetic biology, genetic engineering, clinical-grade manufacturing, and complex logistics to distribute the drug product to treatment sites. A key ambition of the CARAMBA project is to provide clinical proof-of-concept for virus-free CAR gene transfer using advanced Sleeping Beauty (SB) transposon technology. SB transposition in CAR-T engineering is attractive due to the high rate of stable CAR gene transfer enabled by optimized hyperactive SB100X transposase and transposon combinations, encoded by mRNA and minicircle DNA, respectively, as preferred vector embodiments. This approach bears the potential to facilitate and expedite vector procurement, CAR-T manufacturing and distribution, and the promise to provide a safe, effective, and economically sustainable treatment. As an exemplary and novel target for SB-based CAR-T cells, the CARAMBA consortium has selected the SLAMF7 antigen in multiple myeloma. SLAMF7 CAR-T cells confer potent and consistent anti-myeloma activity in preclinical assays in vitro and in vivo. The CARAMBA clinical trial (Phase-I/IIA; EudraCT: 2019-001264-30) investigates the feasibility, safety, and anti-myeloma efficacy of autologous SLAMF7 CAR-T cells. CARAMBA is the first clinical trial with virus-free CAR-T cells in Europe, and the first clinical trial that uses advanced SB technology worldwide.
Marginal ice zone fraction benchmarks sea ice and climate model skill
Authors: Horvat Christopher 
Published: April 2021

AbstractGlobal climate models (GCMs) consistently underestimate the response of September Arctic sea-ice area (SIA) to warming. Modeled SIA losses are highly correlated to global mean temperature increases, making it challenging to gauge if improvements in modeled sea ice derive from improved sea-ice models or from improvements in forcing driven by other GCM components. I use a set of five large GCM ensembles, and CMIP6 simulations, to quantify GCM internal variability and variability between GCMs from 1979–2014, showing modern GCMs do not plausibly estimate the response of SIA to warming in all months. I identify the marginal ice zone fraction (MIZF) as a metric that is less correlated to warming, has a response plausibly simulated from January–September (but not October–December), and has highly variable future projections across GCMs. These qualities make MIZF useful for evaluating the impact of sea-ice model changes on past, present, and projected sea-ice state.
New hominin remains and revised context from the earliest Homo erectus locality in East Turkana, Kenya
Authors: Hammond Ashley S. , Mavuso Silindokuhle S. , Biernat Maryse , Braun David R. , Jinnah Zubair , Kuo Sharon , Melaku Sahleselasie , Wemanya Sylvia N. , Ndiema Emmanuel K. , Patterson David B. , Uno Kevin T. , Palcu Dan V. 
Published: April 2021

AbstractThe KNM-ER 2598 occipital is among the oldest fossils attributed to Homo erectus but questions have been raised about whether it may derive from a younger horizon. Here we report on efforts to relocate the KNM-ER 2598 locality and investigate its paleontological and geological context. Although located in a different East Turkana collection area (Area 13) than initially reported, the locality is stratigraphically positioned below the KBS Tuff and the outcrops show no evidence of deflation of a younger unit, supporting an age of >1.855 Ma. Newly recovered faunal material consists primarily of C4 grazers, further confirmed by enamel isotope data. A hominin proximal 3rd metatarsal and partial ilium were discovered <50 m from the reconstructed location where KNM-ER 2598 was originally found but these cannot be associated directly with the occipital. The postcrania are consistent with fossil Homo and may represent the earliest postcrania attributable to Homo erectus.