bluuebunny/crossref_metadata_2025_split huggingface dataset:
Speed of Information Processing and Working Memory in Children with Cochlear Implants
Authors: Herran Reid , Pisoni David , Kronenberger William 
Published: December 2021

Background: Cochlear implants (CIs) restore partial hearing to deaf children, promoting the development of spoken language skills. However, because of reduced auditory and language experience, children who receive CIs are at risk for delays not only in language skills but also in language-related neurocognitive skills such as verbal working memory (VWM - the ability to retain language information in immediate memory concurrently with other cognitive processing). Although VWM delays in children with CIs are well-documented, the foundational processes underlying these delays are less clear. This study investigated the hypotheses that slower speed of information processing during VWM tasks contributes to VWM delays in CI users and that this slower information processing speed is associated with spoken language outcomes.

Methods: 25 early-implanted, prelingually-deaf children with CIs and 25 normal-hearing (NH) peers completed tests of VWM, neurocognitive, and speech-language functioning. Speed of information processing during the VWM test was assessed by measuring response latency and average pause duration.

Results: Children with CIs showed poorer VWM scores than NH peers, but the groups did not differ on response latencies or pause durations. Response latencies were significantly correlated with VWM capacity, speech, and language outcomes in both groups.

Conclusion: Speed of information processing in VWM was similar for children with CIs and NH. In both groups, shorter response latencies (faster speed of execution of the cognitive operations of working memory) were associated with better neurocognitive and spoken language outcomes. In the CI sample, pause durations were inconsistently associated with VWM and language outcomes.

Clinical Policy Impact and Implications: Speed of information processing for VWM is associated with core neurocognitive and spoken language outcomes for children with CIs and should be a routine target of assessment and intervention post-implantation.
Effect of Passage Number on Human Induced Pluripotent Stem Cell Derived Neurons Culture Contaminants with Non-Neuronal Cell Types
Authors: Ketsoglou Dominique , Cantor Erica , Jiang Guanglong , Wu Xi , Phillips Santosh , Shen Fei , P. Schneider Bryan 
Published: December 2021

Background: The study of live human neurons has been hindered due to the complexity and potential irreversible damage to the patient during biopsy. However, reprogramming of adult human somatic cells into induced pluripotent stem cells (iPSCs) has proved to be a novel method in the study of the pathophysiology of disease and therapeutic targets of the human nervous system. There are several approaches, and the optimum time (i.e., passage number) to generate highly pure cultures is being studied. Therefore, our laboratory has investigated the effect of passage number on culture contaminants with non-neuronal cell types.

Methods: Peripheral blood mononuclear cells (PBMCs) were isolated from whole blood from three cell lines and reprogrammed into iPSCs. Each cell line consisted of three samples that were analyzed after low (5-10), middle (20-26), and high (30-38) number of passages. Cells were maintained in an induction medium for eight days. On day nine, cells were dissociated and replated in a maintenance medium. On day 33, total RNA was extracted from cells. Normalized values for non-neuronal cell marker genes were compared using paired Student’s t-tests and two-way ANOVA, with the cell line and passage number as independent variables. P-values less than 0.05 were considered significant.

Results: Our results showed that lower passage number was associated with decreased astrocyte and chondrocyte marker expression. High passage number was associated with decreased oligodendrocyte and glial precursor marker expression. Of the fibroblast markers evaluated, there were similar trends of expression between all three groups. There was no significant difference in microglial cell marker gene expression between all three groups.

Conclusion and Potential Impact: Low gene expression suggests a purer culture. According to these results, as passage number increases, there is more contaminants with oligodendrocytes and glial precursor cells. Conversely, with low passage numbers, there are more contaminants with astrocytes and chondrocytes. Future studies will identify the impact of these non-neuronal contaminants and implications on research.
Community-based Study on Hip Fracture in a Rural Area in Northeast Indiana
Authors: Kimes Brandon , Zhu Thein 
Published: December 2021

Background/Objective: There are few studies in the literature focused on rural hip fracture epidemiology, and fewer still that consider hip fractures at a specific county level or trauma center (TC) region. The aim of this study is to elucidate patterns of injury events and injury burden of hip fractures in a rural trauma center in northeast Indiana.

Patients and Measurements: We ascertained 2019 hip fracture cases that consisted of three sets of data, namely, emergency department visits (ED), hospitalizations (IP), and deaths from clinical databases. We analyzed the cases by fracture type, measured incidence rates (IRs) per 1,000 county residents and described the injury pattern of hip fractures by variables such as county of residence, age, and sex. We considered the mechanism of injury (cause) of the fractures as well as the injury burden based on the above three sets.

Results: A ratio of roughly 2:1 was found for extracapsular to intracapsular hip fractures. Injury patterns showed that the study counties had similar incidence rates with a range of 0.96 to 1.41 per 1,000 residents. Males and females ages 0-69 years had similar incidences of hip fracture. Overall, females had a 41% higher incidence rate of hip fractures than males. Injury burden indicated a similar distribution of ED to IP to mortality cases across the five study counties, and the majority (98.4%) of hip fractures with known causes of injury were due to falls.

Conclusions and Potential Impact: We elucidated the injury patterns and burden of hip fractures in a verified level II trauma center region. The results of this study have the potential benefit for the future development of hip fracture prevention programs for rural, elderly populations in northeast Indiana.
The potential role of STAT3 In the APE1/NF-kB regulatory axis in K-rasLSL.G12D/+;Pdx-1-Cre (KC) pancreatic tumor model
Authors: Kpenu Eyram , Kelley Mark 
Published: December 2021

APE1/Ref-1 (apurinic/apyrimidinic endonuclease-redox effector factor 1) is a multifunctional protein that has been shown to be overexpressed in multiple types of cancer. The overexpression of APE1/Ref-1 is linked to higher cancer cell survival and increased patient mortality. Furthermore, APE1/Ref-1 is a key regulator of transcription factors (TF) through redox signaling and protein-protein interaction. It is involved in proliferative and inflammatory signaling upregulated in cancer.
Transcription factor NF-kB is involved in inflammatory cytokine expression and has been shown to be regulated by Ref-1. My project investigated how Ref-1 regulates NF-kB, specifically Rel-A, in a model using K-rasLSL.G12D/+; Pdx-1-Cre (KC) pancreatic tumor cells (KC3590) derived from genetically engineered mice. Additionally, I explored other TFs within the APE1/Ref-1 signaling pathway, such as STAT3, in this model.
My work involved knocking down STAT3 levels within four variations of the KC3590 line. These were the KC3590/ΔNF-kB (parent) and KC3590/ΔNF-kB vector lines (vector) which contain exon deletions within the NF-kB gene rendering it nonfunctional. KC3590/13 and KC3590/15 are cell lines which are KC3590/ΔNF-B cells with functional full-length NF-kB added to the cells. Previous experiments demonstrated that the ΔNF-kB and ΔNF-kB vector lines are resistant to treatment by the specific Ref-1 inhibitors, including APX3330, which inhibit the redox signaling function of Ref-1.
Initial data demonstrated that adding back functional NF-kB to the NF-kB deficient cells reestablished sensitivity to APX3330, presumably due to the reintroduction of the Ref-1 target, NF-kB. Knockdown of STAT3 expression in the ΔNF-kB and ΔNF-kB vector lines demonstrated some sensitivity to APX3330, however, in the C13/15 cell lines, no enhanced sensitivity was observed. These data support the hypothesis that NF-kB is the major TF driving the growth of KC pancreatic tumor cells. Subsequent studies will clarify further the role of APE1/Ref-1 regulation in the KC model and the relative importance of APE1/Ref-1’s target TFs.
Como ler um texto acadêmico? Diretrizes para estudantes universitários
Authors: Sahão Fernanda Torres 
Published: December 2021

Objetivo. Propor diretrizes para orientar estudantes universitários na leitura de textos acadêmicos. Desenvolvimento. O artigo apresenta dados sobre a importância do desenvolvimento de um repertório de leitura eficiente e ações a serem apresentadas pelos estudantes para que sejam capazes de ler textos acadêmicos de forma mais produtiva e crítica, divididas em oito diretrizes, sendo elas: caracterizar a estrutura de um texto acadêmico; definir objetivos para a leitura; elaborar perguntas com base no título e subtítulos; avaliar a própria compreensão do texto; avaliar as informações apresentadas; identificar informações desconhecidas; relacionar as informações do texto com outras fontes de informação; e produzir algo novo a partir da leitura. Implicações. Espera-se que as diretrizes apresentadas auxiliem estudantes ou profissionais que necessitem aperfeiçoar o repertório de leitura de textos acadêmicos, e que possam utilizar esse conhecimento também diante de outras fontes de informação, examinando notícias e textos de forma mais crítica e autônoma.Palavras-chave. Leitura funcional; Artigo científico; Avaliação crítica; Ensino superior; Letramento científico. How to read an academic text? Guidelines for college studentsAbstract:Objective. Propose guidelines to guide university students in the reading of academic texts. Development. The article presents data on the importance of developing an efficient reading repertoire and actions to be presented by students so that they are able to read academic texts in a more productive and critical way, divided into eight guidelines, which are: to characterize the structure of an academic text; define objectives for reading; prepare questions based on title and subtitles; evaluate the very understanding of the text; evaluate the information presented; identify unknown information; relate text information to other sources of information; and produce something new from reading. Implications. It is expected that the guidelines presented can help students or professionals who need to improve the repertoire of reading academic texts, and who can use this knowledge also to read other sources of information, examining news and texts in a more critical and autonomous way.Keywords. Functional reading; scientific article; critical evaluation; higher education; scientific literacy.
Can IDEXX Angio Detect™ accurately detect canine Angiostrongylosis?
Authors: Weir Natashia , Ireland Jo 
Published: December 2021

PICO question
In dogs, is IDEXX Angio Detect™ as accurate as Baermann coprology when diagnosing Angiostrongylus vasorum infection?

Clinical bottom line
Category of research question
Diagnosis
The number and type of study designs reviewed
Eight papers were critically reviewed: three diagnostic accuracy studies, two cross-sectional studies (one of which also included a retrospective case series), one cohort study, one case-control study, and one case series
Strength of evidence
Weak
Outcomes reported
Angio Detect™ (IDEXX) was shown to have low-moderate sensitivity and high specificity in comparison to Baermann coprology. Occasionally, false-negative results occurred with Angio Detect™ when compared to Baermann coprology. This was thought to be due to antigen-antibody complex formation. Positive Angio Detect™ assays were obtained in both symptomatic and asymptomatic canine patients. In an experimental setting, Angio Detect™ was shown to obtain a positive result five weeks post-inoculation
Conclusion
There is weak evidence supporting Angio Detect™ as a highly specific and moderately sensitive diagnostic test when compared to Baermann coprology

How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
Transformation Management Office as a Vehicle to Accelerate Digital Transformation
Authors: Al Blooshi Khaled , Mohammed Hassan , Al Awadhi Khalid Yousef , Carreiras Pedro , Al Mansoori Maitha Harahish , Al Ameri Waad , Al Houqani Mouza Sulaiman , ALwedami Amal , Saleh Rasha Humaid , Alsaeedi Ayesha Ahmed , Al Hemeiri Ayesha 
Published: December 2021

Abstract
ADNOC has identified digital technology as a key enabler of sustainable value creation as it delivers its 2030 smart growth strategy. The Transformation Management Office (TMO) has been established to accelerate delivery of ADNOC's digital transformation, actively manage its digital portfolio, build digital capabilities, lead the digital empowerment of local talent and institute a ‘new way to operate’. By doing so, it supports ADNOC's ambition to be a data-driven organization, adopting new ways of working, and delivering greater value, while adapting swiftly to competitive threats to its core business.
ADNOC's digital transformation is changing the way the organization operates. The adoption of digital technologies, including big data, Artificial Intelligence and Machine Learning and robotics will optimize production, improve efficiency, reduce risk and de-risk multibillion dollar projects. To achieve this requires a change of company culture across the full value chain. The decision to establish the Transformation Management Office was a recognition that ADNOC must evolve to meet the realities of the new energy era by adopting advanced digital technologies to ensure we remain resilient and agile, by making the most of our resources, enhancing our performance, empowering our people and delivering greater value for our shareholders, Abu Dhabi and the UAE.
Experimental Investigation of Hydrocarbon Gas Huff-N-Puff Injection into the Live-Oil Window of Eagle Ford
Authors: Tsau Jyun-Syung , Fu Qinwen , Barati Reza Ghahfarokhi , Zaghloul J. , Baldwin A. , Bradford K. , Nicoud B. , Mohrbacher J. D. 
Published: December 2021

Abstract
The hydrocarbon gas huff and puff (HnP) technique has been used to improve oil production in unconventional oil reservoirs where excess capacity of produced gas is available and hydrocarbon prices are in a range to result in an economically viable case. Eagle Ford (EF) is one of the largest unconventional oil plays in the United State where HnP has been applied for enhanced oil recovery (EOR) at reservoirs within various oil windows. Our previously published Huff-n-puff results on dead oil with produced gas from Eagle Ford (EF) showed the recovery factor of hydrocarbon varying from 40 to 58%. The objective of this paper is to extend the experiments to live oil with EF core plugs to investigate the mechanisms of HnP which are affected by the composition of injected gas and resident oil, injection and soaking time as well as injection/depletion pressure gradient.
Eagle Ford live oil and natural gas produced from the target area were used for HnP tests. Four representative core plugs were used with the tests conducted at reservoir conditions (125 °C and 3,500 psi).
The live oil experiments with four reservoir core plugs showed an improvement in oil recovery with recovery factor (RF) varying from 19.5 to 33 % in six cycles of HnP, whereas the primary depletion on the same core plug showed RF below 11 %. A lower recovery factor of HnP from live oil saturated core in this study was observed as compared to dead oil saturated core reported in a previous publication. It is attributed to a lesser diffusion effect on mass transfer between injected gas and resident oil when the core is saturated with live oil. This behavior is displayed by the pressure decline curve during the first soaking period. A sharper diffusion pressure decline occurred in the dead oil saturated core plug where a higher concentration gradient between injected gas and resident oil drives a faster gas transport into the oil due to the molecular diffusion during the soaking period.
Stratigraphic Trap Potential in the Middle East – Examples from the Mesozoic
Authors: Gravestock Christopher , Bromhead Alex , Simmons Mike , Van Buchem Frans , Davies Roger 
Published: December 2021

Abstract
The Mesozoic stratigraphy of the Middle East is endowed with multiple world-class, economically significant petroleum systems. Since the first discovery of a major oilfield in an anticline structure in 1908 (Masjed-e-Suleyman, Iran), exploration and production in the Middle East has been largely focussed on relatively low-risk, large structural traps. However, across the Arabian Plate, unexplored structural traps at similar scales are becoming scarce. Therefore, in this mature petroleum province, attention must now focus on identifying the presence of subtle stratigraphic traps, especially within the hydrocarbon-rich Mesozoic stratigraphy. In order to locate and evaluate subtle stratigraphic traps, we have applied sequence stratigraphic principles across the Mesozoic strata of the Arabian Plate. This approach provides a regional, robust age-based framework which reduces lithostratigraphic uncertainty across international boundaries and offers predictive capabilities in the identification and extent of stratigraphic plays. Herein, we focus on three intervals of Mesozoic stratigraphy, namely Triassic, Middle-Late Jurassic and middle Cretaceous strata, in which regional sequence stratigraphic based correlations have identified stratigraphic trap potential. Each of these stratigraphic intervals are associated with the following stratigraphic traps:Triassic: Sub-crop traps associated with a base Jurassic regional unconformity and intra-Triassic unconformities. Onlap geometries associated with differential topography on the Arabian Plate.Middle-Late Jurassic: Pure stratigraphic trap geometries associated with basin margin progradation and pinch-out plays either side of the Rimthan Arch related to late Oxfordian/early Kimmeridgian sea-level fall.Middle Cretaceous: Sub-crop potential beneath the regional mid-Turonian unconformity, basin margin progradation and stratigraphic pinch-out geometries associated with onlap onto basin margins.
This regional sequence stratigraphic approach highlights the remaining exploration and production opportunities within these hydrocarbon-rich stratigraphic intervals.
Carbon Steel X65QS Pipeline Qualification for Extreme Sour Service a Global Approach: Line Pipe, Welding, Eca Methodology and Diyab Pipeline Case Study
Authors: Luc Lam-Thanh , Saad Hamdi , Tanios Matta , Aamer Dr. Al Bannay , Sirsimth Meer Mumtaz Ali Imtiaz , Antoine Remy , Florian Thebault , Laurent Ladeuille 
Published: December 2021

Abstract
In the wake of failures of large diameter pipelines made from plates using the Thermo-Mechanically Controlled Process (TMCP), the suitability of carbon steel material for sour environments where the H2S partial pressure is largely over 1 bar has been questioned. Understanding that seamless quench and tempered material are not prone to the same phenomenon as large diameter TMCP pipes, it has been decided to ensure the integrity of the DIYAB pipeline by qualification using the actual production environment pH=3.5 at 24°C and 6.84 bar H2S plus 6.84 bar CO2.
The global approach includes the qualification to sour service resistance under 6.84bar H2S of the base material and the welds without post weld heat treatment. Fracture toughness tests under 6.84bar H2S were also conducted, and the results fed into an Engineering Criticality Assessment (ECA) to define the Non-Destructive Testing (NDT) acceptance criteria. The NDT tools were selected for their ability to detect the critical flaws and validated. The global approach methodology and results are presented.
Robust Well Placement Optimization Through Universal Trace Kriging with Adaptive Sampling
Authors: Stabile Carlo Cristiano , Barbiero Marco , Fighera Giorgio , Dovera Laura 
Published: December 2021

Abstract
Optimizing well locations for a green field is critical to mitigate development risks. Performing such workflows with reservoir simulations is very challenging due to the huge computational cost. Proxy models can instead provide accurate estimates at a fraction of the computing time. This study presents an application of new generation functional proxies to optimize the well locations in a real oil field with respect to the actualized oil production on all the different geological realizations.
Proxies are built with the Universal Trace Kriging and are functional in time allowing to actualize oil flows over the asset lifetime. Proxies are trained on the reservoir simulations using randomly sampled well locations. Two proxies are created for a pessimistic model (P10) and a mid-case model (P50) to capture the geological uncertainties. The optimization step uses the Non-dominated Sorting Genetic Algorithm, with discounted oil productions of the two proxies, as objective functions. An adaptive approach was employed: optimized points found from a first optimization were used to re-train the proxy models and a second run of optimization was performed.
The methodology was applied on a real oil reservoir to optimize the location of four vertical production wells and compared against reference locations. 111 geological realizations were available, in which one relevant uncertainty is the presence of possible compartments. The decision space represented by the horizontal translation vectors for each well was sampled using Plackett-Burman and Latin-Hypercube designs. A first application produced a proxy with poor predictive quality. Redrawing the areas to avoid overlaps and to confine the decision space of each well in one compartment, improved the quality. This suggests that the proxy predictive ability deteriorates in presence of highly non-linear responses caused by sealing faults or by well interchanging positions. We then followed a 2-step adaptive approach: a first optimization was performed and the resulting Pareto front was validated with reservoir simulations; to further improve the proxy quality in this region of the decision space, the validated Pareto front points were added to the initial dataset to retrain the proxy and consequently rerun the optimization. The final well locations were validated on all 111 realizations with reservoir simulations and resulted in an overall increase of the discounted production of about 5% compared to the reference development strategy.
The adaptive approach, combined with functional proxy, proved to be successful in improving the workflow by purposefully increasing the training set samples with data points able to enhance the optimization step effectiveness. Each optimization run performed relies on about 1 million proxy evaluations which required negligible computational time. The same workflow carried out with standard reservoir simulations would have been practically unfeasible.