bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for recurrence of radically resected mucinous colorectal adenocarcinoma
Authors: Huang Qing , Zou Min-hong , Wei Jian-chang , Jiang Ye , Chen Zhuan-peng , Wang Qiang , Li Wang-lin , Cao Jie 
Published: February 2021

Abstract
Background Local recurrence and distant metastasis are major challenges to overcome in order to improve the survival of patients with colorectal cancer (CRC) after surgery. Mucinous adenocarcinoma (MA) is a subtype of CRC associated with a higher incidence of local extension and worse survival compared to non-mucinous adenocarcinoma, but few studies have investigated predictors for poor clinical outcome of MA. Therefore, we aimed to elucidate the predictors for local recurrence and remote metastasis of MA after surgery.Methods This study retrospectively analyzed 162 patients with mucinous colorectal adenocarcinoma (MAC) after radical resection. Analysis variables included demographics, clinical indicators, pathologic stage, surgical procedure, adjuvant therapy, and recurrence. Univariate and multivariate analyses were performed to investigate the risk factors for local and distant tumor relapse.Results A total of 162 patients (86 male) with a mean age of 58.26 years were included; 70.37% of patients had colonic tumors, and 29.63% had rectal tumors. The 5-year disease-free survival (DFS) rates for these patients were as follows: 100% for TNM stage I, 71.2% for stage II, and 47.8% for stage III. Five-year DFS rates of MAC, colonic and rectal MA were 62.0%, 65.8%, and 51.7%, respectively. Local recurrence occurred in 38 patients (23.5%) and distant metastasis in 33 patients (20.4%). In univariate analysis, predictors for local recurrence of MAC were intra-operative blood loss (p=0.004, OR=1.005), intra-operative transfusion (p=0.002, OR=5.179), and N2 stage (p=0.000, OR=4.643), and predictors for distant metastasis were male sex (p=0.035, OR=2.410), CA199 (p=0.011, OR=1.004), CEA (p=0.020, OR=1.010), intra-operative blood loss (p=0.022, OR=1.003), T4 stage (p=0.007, OR=4.125), and N2 stage (p=0.018, OR=3.4). In multivariate analysis, predictors for local recurrence of colorectal MA were intra-operative transfusion (p=0.04, OR=4.175) and N2 stage (p=0.000, OR=5.291), and predictors for distant metastasis were male sex (p=0.049, OR=2.410), CA199 (p=0.02, OR=1.003), and T4 stage (p=0.007, OR=4.006).Conclusions Intra-operative transfusion and N2 stage were significant predictors for local recurrence. Male sex, CA199, and T4 stage were significant predictors for distant metastasis. Knowledge of the risk factors for postoperative recurrence provides a basis for logical approaches to treatment and follow-up of mucinous colorectal adenocarcinoma.
Investigation of Synovial Fluid Lubricants and Inflammatory Cytokines in the Horse: a Comparison of Recombinant Equine Interleukin 1β-induced&nbsp;Synovitis and Joint Lavage Models
Authors: Watkins Amanda , Fasanello Diana , Stefanovski Darko , Schurer Sydney , Caracappa Katherine , D’Agostino Albert , Costello Emily , Freer Heather , Rollins Alicia , Read Claire , Su Jin , Colville Marshall , Paszek Matthew , Wagner Bettina , Reesink Heidi 
Published: February 2021

Abstract
Background

Lameness is a debilitating condition in equine athletes that leads to more performance limitation and loss of use than any other medical condition. There are a limited number of non-terminal experimental models that can be used to study early inflammatory and synovial fluid biophysical changes that occur in the equine joint. Here, we compare the well-established carpal IL-1β-induced synovitis model to a tarsal intra-articular lavage model, focusing on serial changes in synovial fluid inflammatory cytokines/chemokines and the synovial fluid lubricating molecules lubricin/proteoglycan 4 and hyaluronic acid. The objectives of this study were to evaluate clinical signs; synovial membrane and synovial fluid inflammation; and synovial fluid lubricants and biophysical properties in response to carpal IL-1β synovitis and tarsal intra-articular lavage.
Results

Hyaluronic acid (HA) concentrations, especially high molecular weight HA, and synovial fluid viscosity decreased after both synovitis and lavage interventions. Synovial fluid lubricin concentrations increased 17-20-fold for both synovitis and lavage models, with similar changes in both affected and contralateral joints, suggesting that repeated arthrocentesis alone resulted in elevated synovial fluid lubricin concentrations. Synovitis resulted in a more severe inflammatory response based on clinical signs (temperature, heart rate, respiratory rate, lameness and joint effusion) and clinicopathological and biochemical parameters (white blood cell count, total protein, prostaglandin E2, sulfated glycosaminoglycans, tumor necrosis factor-α and CC chemokine ligands − 2, -3, -5 and − 11) as compared to lavage.
Conclusions

Synovial fluid lubricin increased in response to IL-1β synovitis and joint lavage but also as a result of repeated arthrocentesis. Frequent repeated arthrocentesis is associated with inflammatory changes, including increased sulfated glycosaminoglycan concentrations and decreased hyaluronic acid concentrations. Synovitis results in more significant inflammatory changes than joint lavage. Our data suggests that synovial fluid lubricin, TNF-α, CCL2, CCL3, CCL5, CCL11 and sGAG may be useful biomarkers for synovitis and post-lavage joint inflammation. Caution should be exercised when performing repeated arthrocentesis clinically or in experimental studies due to the inflammatory response and loss of HA and synovial fluid viscosity.
Five-year Microevolution of a Multidrug-Resistant Mycobacterium Tuberculosis Strain within a Patient with Inadequate Compliance to Treatment.
Authors: Porto Dario Fernández Do , Monteserin Johana , Campos Josefina , Sosa Ezequiel J , Matteo Mario , Serral Federico , Yokobori Noemí , Benevento Andrés Fernández , Poklepovich Tomás , Pardo Agustín , Wainmayer Ingrid , Simboli Norberto , Florencia Castello , Paul Roxana , Martí Marcelo , López Beatriz , Turjanski Adrián , Ritacco Viviana 
Published: February 2021

Abstract
BackgroundWhole-genome sequencing has shown that the Mycobacterium tuberculosis infection process can be more heterogeneous than previously thought. Compartmentalized infections, exogenous reinfections, and microevolution are manifestations of this clonal complexity. The analysis of the mechanisms causing the microevolution —the genetic variability of M. tuberculosis at short time scales— of a parental strain into clonal variants with a patient is a relevant issue that has not been yet completely addressed. To our knowledge, a whole genome sequence microevolution analysis in a single patient with inadequate adherence to treatment has not been previously reported.Case Presentations In this work, we applied whole genome sequencing for a more in-depth analysis of the microevolution of a parental Mycobacterium tuberculosis strain into clonal variants within a patient with poor treatment compliance in Argentina. We analyzed the whole-genome sequence of 8 consecutive Mycobacterium. tuberculosis isolates obtained from a patient within 57-month of intermittent therapy. Nineteen mutations (9 short-term, 10 fixed variants) emerged, most of them associated with drug resistance. The first isolate was already resistant to isoniazid, rifampicin, and streptomycin, thereafter the strain developed resistance to fluoroquinolones and pyrazinamide. Surprisingly, isolates remained susceptible to the pro-drug ethionamide after acquiring a frameshift mutation in ethA, a gene required for its activation. We also found a novel variant, (T-54G), in the 5' untranslated region of whiB7 (T-54G), a region allegedly related to kanamycin resistance. Notably, discrepancies between canonical and phage-based susceptibility testing to kanamycin were previously found for the isolate harboring this mutation. In our patience, microevolution was mainly driven by drug selective pressure. Rare short-term mutations fixed together with resistance-conferring mutations during therapy.ConclusionsThis report highlights the relevance of whole-genome sequencing in the clinic for characterization of pre-XDR and MDR resistance profile, particularly in patients with incomplete and/or intermittent treatment.
Association of Opioid Use Disorder With 2016 Presidential Voting Patterns: Cross-sectional Study in New York State at Census Tract Level
Authors: Xiang Anthony , Hou Wei , Rashidian Sina , Rosenthal Richard N , Abell-Hart Kayley , Zhao Xia , Wang Fusheng 
Published: February 2021

Background
Opioid overdose-related deaths have increased dramatically in recent years. Combating the opioid epidemic requires better understanding of the epidemiology of opioid poisoning (OP) and opioid use disorder (OUD).

Objective
We aimed to discover geospatial patterns in nonmedical opioid use and its correlations with demographic features related to despair and economic hardship, most notably the US presidential voting patterns in 2016 at census tract level in New York State.

Methods
This cross-sectional analysis used data from New York Statewide Planning and Research Cooperative System claims data and the presidential voting results of 2016 in New York State from the Harvard Election Data Archive. We included 63,958 patients who had at least one OUD diagnosis between 2010 and 2016 and 36,004 patients with at least one OP diagnosis between 2012 and 2016. Geospatial mappings were created to compare areas of New York in OUD rates and presidential voting patterns. A multiple regression model examines the extent that certain factors explain OUD rate variation.

Results
Several areas shared similar patterns of OUD rates and Republican vote: census tracts in western New York, central New York, and Suffolk County. The correlation between OUD rates and the Republican vote was .38 (P<.001). The regression model with census tract level of demographic and socioeconomic factors explains 30% of the variance in OUD rates, with disability and Republican vote as the most significant predictors.

Conclusions
At the census tract level, OUD rates were positively correlated with Republican support in the 2016 presidential election, disability, unemployment, and unmarried status. Socioeconomic and demographic despair-related features explain a large portion of the association between the Republican vote and OUD. Together, these findings underscore the importance of socioeconomic interventions in combating the opioid epidemic.
Pesticide Exposure of Residents Living Close to Agricultural Fields in the Netherlands: Protocol for an Observational Study
Authors: Figueiredo Daniel M , Krop Esmeralda J M , Duyzer Jan , Gerritsen-Ebben Rianda M , Gooijer Yvonne M , Holterman Henk J , Huss Anke , Jacobs Cor M J , Kivits Carla M , Kruijne Roel , Mol Hans J G J , Oerlemans Arné , Sauer Pieter J J , Scheepers Paul T J , van de Zande Jan C , van den Berg Erik , Wenneker Marcel , Vermeulen Roel C H 
Published: February 2021

Background
Application of pesticides in the vicinity of homes has caused concern regarding possible health effects in residents living nearby. However, the high spatiotemporal variation of pesticide levels and lack of knowledge regarding the contribution of exposure routes greatly complicates exposure assessment approaches.

Objective
The objective of this paper was to describe the study protocol of a large exposure survey in the Netherlands assessing pesticide exposure of residents living close (<250 m) to agricultural fields; to better understand possible routes of exposure; to develop an integrative exposure model for residential exposure; and to describe lessons learned.

Methods
We performed an observational study involving residents living in the vicinity of agricultural fields and residents living more than 500 m away from any agricultural fields (control subjects). Residential exposures were measured both during a pesticide use period after a specific application and during the nonuse period for 7 and 2 days, respectively. We collected environmental samples (outdoor and indoor air, dust, and garden and field soils) and personal samples (urine and hand wipes). We also collected data on spraying applications as well as on home characteristics, participants' demographics, and food habits via questionnaires and diaries. Environmental samples were analyzed for 46 prioritized pesticides. Urine samples were analyzed for biomarkers of a subset of 5 pesticides. Alongside the field study, and by taking spray events and environmental data into account, we developed a modeling framework to estimate environmental exposure of residents to pesticides.

Results
Our study was conducted between 2016 and 2019. We assessed 96 homes and 192 participants, including 7 growers and 28 control subjects. We followed 14 pesticide applications, applying 20 active ingredients. We collected 4416 samples: 1018 air, 445 dust (224 vacuumed floor, 221 doormat), 265 soil (238 garden, 27 fields), 2485 urine, 112 hand wipes, and 91 tank mixtures.

Conclusions
To our knowledge, this is the first study on residents’ exposure to pesticides addressing all major nondietary exposure sources and routes (air, soil, dust). Our protocol provides insights on used sampling techniques, the wealth of data collected, developed methods, modeling framework, and lessons learned. Resources and data are open for future collaborations on this important topic.

International Registered Report Identifier (IRRID)
RR1-10.2196/27883
SEXO SEM PRESERVATIVO SOB A ÓTICA DAS REPRESENTAÇÕES SOCIAIS DE ACADÊMICOS DE UMA UNIVERSIDADE PÚBLICA
Authors: Almeida Júnior José Andrade , De Oliveira Diego Gabriel Santos , Suto Cleuma Sueli Santos , Porcino Carle , Costa Laura Emmanuela Lima 
Published: February 2021

Apreender as representações sociais de acadêmicos de uma universidade pública sobre o não uso do preservativo nas relações sexuais. Estudo descritivo e qualitativo. Realizado com participação de 215 estudantes de uma universidade pública, no período de Março a Dezembro de 2017, para coleta de dados. Participantes em sua maioria mulheres, cristãs, heterossexuais com vida sexual ativa. Chamando atenção que parcela considerável afirmou não gostar de usar o preservativo e/ou não possuir acesso direto. Das evocações, um quadro de quatro casas, trazendo um núcleo central com os termos “Infecções Sexualmente Transmissíveis, Gravidez, Gravidez indesejada e Risco”, duas periferias próximas e uma periferia distante. No núcleo central, os participantes evidenciam os aspectos negativos do sexo sem proteção, apontando o medo de infecções sexualmente transmissíveis e uma gravidez indesejada, no entanto contrapõe essa perspectiva ao assumirem uma postura sexual vista como arriscada.
Rancang Bangun Purwarupa Lengan Robot Berbantuan Raspberry Pi
Authors: Ludony Stephanie Graciela , Mulyadi Melisa , Indriati Kumala 
Published: February 2021

Persaingan di bidang industri telah mendorong untuk dilakukannya proses otomasi dalam mengoperasikan peralatan mesin-mesin industri dan kontrol proses untuk menggantikan operator tenaga manusia. Teknologi robot merupakan bagian dari otomasi yang banyak diterapkan di industri, salah satunya adalah lengan robot. Pada proses produksi, lengan robot digunakan untuk memindahkan objek. Dibutuhkan perancangan yang benar agar lengan robot dapat bergerak sesuai dengan kriteria yang diinginkan. Oleh karena itu pada penelitian ini dilakukan perancangan dan pembuatan purwarupa lengan robot yang memiliki lima derajat kebebasan atau Degree of Freedom (DoF) dan dilengkapi dengan pencapit objek. Sebagai pengendali lengan robot digunakan mikrokomputer Raspberry Pi 3 Model B+ yang diprogram dengan perangkat lunak python. Pada lengan robot terdapat kamera untuk mendeteksi warna objek agar lengan robot dapat memindahkan dan menempatkan objek sesuai kelompok warnanya. Pengujian terhadap rancangan lengan robot menunjukkan bahwa kamera dapat mengenali warna objek dan lengan dapat memindahkan objek sesuai pada tempatnya.

Competition in the industrial sector has pushed for automation processes in operating industrial machine tools and process control to replace human labor operators. Robot technology is a part of automation that is widely applied in industry, one of which is the robot arm. In the production process, robotic arms are used to move goods. Correct design is needed so that the robot arm can move according to the desired criteria. Therefore, in this study, the design and manufacture of a robot arm prototype that has five degrees of freedom (DoF) is carried out and is equipped with a clamp. As a controller for the robot arm, a Raspberry Pi 3 Model B + microcomputer is used, which is programmed with python software. On the robot arm, there is a camera to detect the color of the object so that the robot arm can move and place object according to the color group. Testing of the robot arm design shows that the camera can recognize the color of goods and the robot arm can move object according to their place.
La Pantruca "Estampa Mulata", inédita y prostibularia
Authors: Escajadillo Tomás G. 
Published: February 2021

A la memoria de doña Renée González de Diez-Canseco (1986).
El problema que implicaba anteceder a un conjunto de “estampas mulatas” compuesto por dos novelas cortas y siete cuentos, un “prólogo” referido sólo a “cuatro cuentos” ese vidente en la edición de 1951. Es por ello que, al encargarme de una nueva edición de las Estampas Mulatas para la “Colección de Autores Peruanos” de la Editorial Universo, junto con separarlas dos novelas iniciales —El Gaviota y El Kilómetro 83—acompañadas del importante prólogo de Federico More con que aparecieran en 1930 como libro independiente (en el que el término “estampas mulatas” aparecía como una suerte de subtítulo), este prólogo de Diez-Conseco, que antecede a la segunda sección, “Cuentos”, es materia de la siguiente precisión.
IS THERE AN ORGAN-SPECIFIC EXPRESSION OF CANDIDATE GENES (DJ1, PINK1) IN TISSUES OF THE ORGANISM UNDER EXPERIMENTAL PARKINSONISM AND ITS PATHOGENETIC THERAPY?
Authors: Rozova Kateryna Vsevolodovna  , Putiy Yuliya Vladimirovna  
Published: February 2021

It have been studied the changes in the structural and functional state of mitochondria and expression of PINK1 and DJ1 genes in brain tissue - medulla oblongata and striatum and lung and heart tissue in experimental parkinsonism and its pathogenetic treatment with the help of a broad-spectrum antihypoxant Kapikor. It was shown that undrt experimental parkinsonism, in addition to damage to the ultrastructure of the mitochondrial apparatus in cells of body tissues, there are significant changes in mRNA expression of DJ1 and PINK1 genes, which are associated with the formation of mitochondrial dysfunction. They have a multidirectional character in the tissues of the brain - decrease, and in the tissues of the heart and lungs - increase. The degree of such changes in expression is organ-specific and more pronounced in the tissues of the visceral organs than in the tissues of the brain. Also, it was shown that the use of broad-spectrum antioxidant, which contains mildenium dehydrate and gamma-butyrobetaine dihydrate, there are significant changes in the expression of mRNA genes DJ1 and PINK1, which are also organ-specific - the expression of mRNA of all DJ1 genes increased in to a greater extent, the expression of PINK1 gene mRNA decreased sharply in brain tissues, and also increased sharply in lung and heart tissues. The data obtained indicate a complex and ambiguous relationship between the level of expression of the studied candidate genes involved in the formation of experimental parkinsonism, and the severity of mitochondrial dysfunction, which is one of the pathogenetic causes of parkinsonism.
Pengaruh Total Debt Equity Ratio (DER) dan Total Asset Turnover (TATO) Terhadap Profitabilitas (ROE) pada Perusahaan Manufaktur yang Terdaftar di Bursa Efek
Authors: Ambari Rahmi , Indrawan Andri , Sudarma Ade 
Published: February 2021

The purpose of this study is to determine the effect of Total Debt Equity Ratio (DER) and Total Asset Turnover (TATO) on Profitability (ROE) in Manufacturing Companies listed on the IDX. The research method used is quantitative, with associative approaches. The sampling technique used in this study was nonprobability sampling with purposive sampling technique. The data analysis technique used in this study is the normality test and partial test (t test). The results of the partial test (t test) show that the tcount of variables The total debt equity ratio (DER) is 1.660 with a significant level of more than 0.05, which is 0.105 (0.105> 0.05), tcount = 1.660 <table = 2014, then Ho is accepted and Ha is rejected, which means that the Total debt equity ratio does not have a significant effect on profitability (ROE) and tcount of the variable Total asset turnover (TATO) of 3,341 with a significant level of less than 0.05 which is 0.002 (0.002 <0.05). Tcount = 3,341> t table = 2014. The results of this study show that partially only total asset turnover has an effect on profitability (ROE).
Keywords : Total Debt Equity Ratio (DER), Total Asset Turnover (TATO), Return on Equity (ROE)
Analisis Financial Distress dengan Menggunakan Model Grover pada Perusahaan Sektor Property, Real Estate dan Kontruksi
Authors: Januar Firhan Dwi , Norisanti Nor , Mulia Faizal 
Published: February 2021

This study aims to determine the Grover model that can predict Financial Distress in the property, real estate and construction sector companies listed on the IDX, namely PT. Alam Sutera Realty Tbk, PT. Cowell Development Tbk, PT. Intiland Development Tbk. This study uses descriptive analysis techniques with a quantitative approach to systematically describe predictions of Financial Distress of a company. The results showed that the three companies had a score of more than or equal to 0.01 (G 1 0.01) within 3 years with details, in 2015 PT. Alam Sutera Realty Tbk obtained a score of 0.430, 2016 obtained a score of 0.405, and in 2017 obtained a score of 0.473. PT. Cowell Development Tbk in 2015 obtained a score of 0.198, in 2016 obtained a score of 0.345, and in 2017 obtained a score of 0.368. while PT. Intiland Development Tbk in 2015 obtained a score of 0.661, 2016 obtained a score of 0.610, and in 2017 obtained a score of 0.554. Conclusions based on the results of the study show that the three companies did not experience Financial Distress because all company scores exceeded the score limit determined by the Grover model, in the sense that the company is in a healthy state.
Keywords: Financial Distress, Grover model
Analisis Tingkat Pengembalian Saham pada Industri Dasar Kimia Subsektor Logam
Authors: Pratama Gelar Rialdi , Sunarya Erry , Samsudin Acep 
Published: February 2021

This study aims to determine how much return on shares contained in PT. Lion Metal Work with the Earning Per Share (EPS) method, and also wants to know the rate of return on debt at PT. Lion Metal Work with the Debt To Equity Ratio method. The results of this study state that the value of Earning Per Share in 2015-2016 has increased above the industry average standard, and in 2017 the company has decreased below the industry average standard, while the results of the Debt to Equity Ratio state that the company in 2015-2017 has increased but the value of the Debt To Equity Ratio is less than the industry average standard. The company's problems are in the performance of companies that are experiencing a decline and the value of profits continues to decline and the total debt continues to grow. Conclusions, based on the results and analysis of research data, the return of company shares is not good, as well as the return of debts that are categorized as small or not good because of an increase in debt from year to year while the rate of return on corporate debt is small.
Keywords: Earning Per Share, stock returns, Debt To Equity Ratio.