bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sevoflurane for fiberoptic intubation in patients with pharyngeal or laryngeal tumor and severe comorbidities: A retrospective analysis
Authors: Breuer-Kaiser Andreas Friedrich Christoph , Nicolaescu Ana , Herzog-Niescery Jennifer , Bellgardt Martin , Vogelsang Heike , Weber Thomas Peter , Dazert Stefan , Volkenstein Stefan , Gude Philipp 
Published: April 2021

Abstract
Background: Current guidelines recommend fiberoptic intubation as the gold standard for intubating patients with “difficult airways.” An awake, spontaneously breathing patient provides some degree of safety; however, many patients require sedation. Sedation may impair spontaneous breathing and counteract the benefits of an “awake fiberoptic intubation.” Sevoflurane might be an alternative to intravenous sedative drugs as it preserves spontaneous breathing and provides patient comfort. For this, we implemented a sevoflurane-based protocol to improve the safety of fiberoptic intubation in high-risk patients with severe comorbidities.Methods: We enrolled 29 patients with pharyngeal or laryngeal carcinoma who had undergone fiberoptic intubation with sevoflurane due to a “difficult airway.” The primary endpoint was the preservation of spontaneous breathing during airway management. Secondary endpoints were drop in oxygen saturation to < 90%, the success rate and duration of intubation, the use of intravenous sedative drugs, changes in vital parameters, complications, and awareness. Results: Preservation of spontaneous breathing was possible in all procedures. Fiberoptic intubation was successful in 25 procedures. In three cases, a video laryngoscope was used. One patient suffering from an unidentified trans-cricoid fistula exhaled sevoflurane before an adequate depth of sedation was achieved. In this patient, oxygen saturation dropped to 71%. In the other 28 patients, oxygen saturation did not drop below 90%. The vital parameters did not change significantly. One fiberoptic intubation was complicated by epistaxis, and four patients had moderate bronchial spasm. None of the patients were able to recall the procedure. Conclusions: We concluded that a sevoflurane-based fiberoptic intubation in patients with “difficult airways” and relevant comorbidities is technically feasible. A trans-cricoid fistula is probably a contraindication for this approach.
The previous stretching to resistance training promotes adaptations on the postsynaptic region in different myofiber types
Authors: Jacob Carolina dos Santos , Barbosa Gabriela Klein , Rodrigues Mariana Pasquini , Neto Jurandyr Pimentel , Rocha Lara Caetano , Ciena Adriano Polican 
Published: April 2021

Abstract
This investigation revealed the postsynaptic morphological adaptations in static stretching, resistance training, and their association in adult male Wistar rats. We processed the soleus and plantaris muscle for histochemical (muscle hypertrophy) and postsynaptic region imaging techniques. We observed muscle hypertrophy in both groups submitted to resistance training, even though the cross-section area is larger when there is no previous static stretching. The soleus postsynaptic region revealed an increase in compactness and fragmentation index in combined exercise. The resistance training promotes high adaptations in the postsynaptic area of plantaris; moreover, the previous static stretching decreased this area. In conclusion, the neuromuscular system’s components respond according to the myofiber type even though it is the same physical exercise. Besides, static stretching (isolated or combined) plays a crucial role in neuromuscular adaptations.
Relationship Between Nighttime Emergency Department Admission and Adherence to a Sepsis Treatment Bundle
Authors: You Je Sung , Park Yoo Seok , Chung Sung Phil , Lee Hye Sun , Jeon Soyoung , Kim Won Young , Shin Tae Gun , Jo You Hwan , Kang Gu Hyun , Choi Sung Hyuk , Suh Gil Joon , Ko Byuk Sung , Han Kap Su , Shin Jong Hwan , Kong Taeyoung 
Published: April 2021

Abstract
Background: Nighttime hospital admission is often associated with increased mortality risk in various diseases. Following sepsis campaign implementation, this study investigated compliance rates with the Surviving Sepsis Campaign 3-h bundle for daytime and nighttime emergency department (ED) admissions and the clinical impact of compliance on mortality. Methods: We conducted an observational study using data from a prospective, multicenter registry for septic shock provided by the Korean Shock Society from 11 institutions from November 2015 to December 2017. The outcome was the compliance rate with the complete 3-hour treatment bundle according to the time of arrival in the ED. Mediation analysis was conducted to evaluate the proportion of the total effect that could be explained by hospital admission times.Results: A total of 2,247 patients were enrolled. Compared with daytime admission, nighttime admission was associated with higher compliance for the administration of antibiotics within 3-h (adjusted odds ratio (AOR), 1.276; 95% confidence interval (95% CI), 1.050–1.550, p=0.014), vasopressor within 3-h (AOR, 1.235; 95% CI, 1.009–1.512; P=0.031) and for the administration of the complete 3-h bundle (AOR, 1.231; 95% CI, 1.004–1.501; P=0.046), likely as a result of the increased volume of patients admitted during daytime hours. Consequently, daytime hospital admission adversely affected in-hospital and 28-day mortality rates, mediated by decreased compliance with the complete 3-h bundle. Conclusions: Septic shock patients admitted to the ED during the daytime exhibited lower sepsis bundle compliance than those admitted at night. Despite sepsis campaign implementation, factors that decrease bundle compliance should be reconsidered in patients with septic shock.
Comparative genome and transcriptome integration studies reveal the mechanism of pectoral muscle development and function in pigeons
Authors: Hou Haobin , Wang Xiaoliang , Yang Changsuo , Cai Xia , Lv Wenwei , Tu Yingying , Aodungerile Bao , Wu Quanli , Zhao Weimin , Yao Junfeng , Ding Weixing 
Published: April 2021

Abstract
Background: Various morphological breeds of rock pigeons have emerged as a result of human domestication. Pigeon breed resources provide a genetic model for the study of phenomics. The pectoral muscles are play a key role for the meat production performance of the meat pigeon and the athletic ability of the High flyers. Euro-pigeons and Silver King are commercial varieties that exhibit good meat production performance. In contrast to the domestication direction of meat pigeons, the traditional Chinese ornamental pigeon breed, High flyers, has a small and light body. Here, we investigate the molecular mechanism of the pectoral muscle development and function of pigeons using whole-genome and RNA sequencing data
Result: The selective sweep analysis (FST and log2 (θπ ratio)) revealed 293 and 403 positive selection genes in Euro-pigeons and Silver King, respectively, of which 65 genes were shared. With the Silver King and Euro-pigeon as the control group, the High flyers were selected for 427 and 566 genes respectively. There were 673 differentially expressed genes in the breast muscle transcriptome between the commercial meat pigeons and ornamental pigeons. Pigeon genome selection signal combined with the breast muscle transcriptome revealed that 6 genes from commercial varieties of pigeons and 5 genes from Chinese traditional ornamental pigeons were positively selected. These genes were involved in pathways related to muscle development and function.
Conclusion: Integrated selection signal, transcriptome analysis, and functional annotation identified SYNE1 as a key gene enriched in the actin binding and muscle cell differentiation pathways. Moreover, SYNE1 gene mutations have been associated with human muscular dystrophy. The differential expression of this gene reveals that it has a negative regulatory role in the development and function of pigeon breast muscle.
RSST-ARGM: A Data-Driven Approach to Long-term Sea Surface Temperature Prediction
Authors: Zhu Linqian , Liu Qi , Liu Xiaodong , Zhang Yonghong 
Published: April 2021

Abstract
For the purpose of exploring the long-term variation of regional SST, this paper studies the historical SST in local sea areas and the emission pattern of greenhouse gases and proposes a gray model of regional SST based on atmospheric reflection which can be used to predict SST variation in a long time span. By studying the grey systematic relationship between historical SST data, the model obtains the development law of temperature change, and further introduces different future greenhouse gas emission scenarios as the index coefficient to determine the corresponding changing results of seawater temperature in the next 50 years. Taking the North Atlantic Ocean as an example, the cosine similarity test method is used to verify the model proposed in this paper, and its accuracy is as high as 0.99984. The model predicts that the local SST could reach a maximum of 15.3℃ by 2070. This model is easy to calculate, with advantages of the high accuracy and good robustness.
High performance optical filters in silicon nanowires with coupled Sagnac loop reflectors
Authors: Arianfard hamed , wu jiayang , juodkazis saulius , moss david 
Published: April 2021

Abstract
We present theoretical designs of high performance optical filters in integrated silicon photonic nanowire resonators. We use mode interference in formed by zig-zag waveguide coupled Sagnac loop reflectors (ZWC-SLRs), tailored to achieve diverse filtering functions with good performance. These include compact bandpass filters with improved roll-off, optical analogues of Fano resonances with ultrahigh spectral extinction ratios (ERs) and slope rates, and resonance mode splitting with high ERs and low free spectral ranges. The analysis verifies the feasibility of multi-functional integrated photonic filters based on ZWC-SLR resonators for flexible spectral engineering in diverse applications.
Long-term water-energy demand prediction using a regression model: a case study of Addis Ababa city
Authors: Kitessa Bedassa Dessalegn , Ayalew Semu Moges , Gebrie Geremew Sahilu , Teferi Solomon Tesfamariam 
Published: April 2021

Abstract
As part of sustainable urban planning, the demand for water and energy (WE) should also be addressed. The Waikato Environment for Knowledge Analysis (WEKA) modeling tool was employed to relate the historical WE consumptions with the population and economic growth scenarios using a linear regression model. The performance of the model was evaluated to properly identify the most influential drivers in each sector. The WE demand prediction was made for each year from 2016 up to 2050. Consequently, the long-term time interval for demand analysis is important rather than the consequent year for planning. The total electric energy demand including residential, street-lighting, commercial and industrial sectors was estimated to be around 14,000 and 53,000 Giga Watt hour (GWh) for the years 2030 and 2050, respectively. These years' forecasted petroleum demand was around 8840 and 30,140 for diesel, 13,860 and 52,700 for gasoline, and 1230 and 9890 GWh for kerosene and the water demand including residential, commercial and industrial sectors were 520 and 1600 million cubic meters (MCM). The proposed methodology can comfortably be used to predict the urban WE demand corresponding to economic (gross domestic product and per capita income) and population growth at different scenarios which could support policy makers.
Water quality in relation to land use in the Junshan Lake watershed and water quality predictions
Authors: Lu Jiangang , Cai Haisheng , Zhang Xueling , Fu Yanmei 
Published: April 2021

AbstractChanges in human-dominated spatial patterns of land use are the main driving factors of water quality evolution in watersheds, and the quantitative impact of land use changes on water quality is currently a focus of lake ecology research. Using the Junshan Lake Basin as a study area, this paper quantitatively analyzes the response relationships between the water quality parameters, land use, and socio-economic factors in the study area from 2005 to 2019 and predicts the water quality in 2035 based on land and space planning scenarios. The results show the following. (1) The land use structure of the Junshan Lake Basin has changed significantly over the last 15 years. The basic trend is an increase in settlement and wetland areas in the basin and a decrease in water, cropland, forest, and grassland areas. (2) Settlement areas play the role of a ‘source’ for the total phosphorus (TP) and ammonium-nitrogen (NH3-N) pollution load, and cropland areas play the role of a ‘sink’ for the TP, NH3-N, and chemical oxygen demand (CODMn) pollution load. (3) The main land use type in the Junshan Lake Basin is cropland, which accounts for more than 40% of the total, and the water quality in the lake is affected not only by non-point source pollution but also by the regional Gross Domestic Product (GDP), total population, and per capita disposable income. According to the water quality prediction and analysis, the concentrations of TN and TP in Junshan Lake will meet the Class IV water quality standard in 2035, and the concentrations of dissolved oxygen (DO) and CODMn will meet the Class II standard. This study is significant for the management and control of the water environment in the Junshan Lake Basin.
An agent-based model for water allocation optimization and comparison with the game theory approach
Authors: Noori Mahsa , Emadi Alireza , Fazloula Ramin 
Published: April 2021

Abstract
Despite the advancement of technical tools for the analysis of complex systems, the most important issue in solving water resource problems focuses on the interaction of human and natural systems. Agent-Based Model (ABM) has been used as an effective tool for the development of integrated human and environmental models. One of the main challenges of this method is identifying and describing the main agents. In this study, three main approaches including Genetic Algorithm (GA), cooperative game theory and ABM have been used to optimize water allocation in Tajan catchment. The proposed ABM is a new equation for calculating stakeholder utility and simulating their interactions that can create a hydrological-environmental-human relationship for demand management and optimal water allocation. The results showed that the total benefit of cooperative game theory and ABM relative to GA has been increased 24% and 21% respectively. Although the total benefit in game theory is greater than the ABM, but the ABM considering the agents feedback propose a more comprehensive approach to optimal water allocation.
Design, Synthesis, and In Silico Studies of Novel N-(2-Aminophenyl)-2,3- Diphenylquinoxaline-6-Sulfonamide Derivatives Targeting Receptor- Binding Domain (RBD) of SARS-CoV-2 Spike Glycoprotein and their Evaluation as Antimicrobial and Antimalarial Agents
Authors: Siddiqui Falak A. , Khan Sharuk L. , Marathe Rajendra P. , Nema Nitin V. 
Published: April 2021

Background:
Pneumonia induced by a novel coronavirus (SARS-CoV-2) was named
coronavirus disease 2019 (COVID-19). The Receptor-binding domain (RBD) of SARS-CoV-2 spike
glycoprotein causes invasion of the virus into the host cell by attaching with human angiotensinconverting
enzyme-2 (hACE-2), which leads to further infection.

Objectives:
The novel N-(2-aminophenyl)-2,3-diphenylquinoxaline-6-sulfonamide derivatives were
designed and synthesized to inhibit the RBD of SARS-CoV-2 spike glycoprotein by applying molecular
docking tools.

Methods:
The synthesized products were characterized by Infrared Spectroscopy (IR) and 1H Nuclear
Magnetic Resonance (NMR).

Results:
All the derivatives were found to have a very good binding affinity between -9 to -10.1
kcal/mol, better than the drugs which are under investigation for the treatment of SARS-CoV-2 infection.
Compound F1 formed 4 hydrogen bonds whereas, F4 and F10 formed two hydrogen bonds
each with RBD of SARS-CoV-2 spike glycoprotein. All the derivatives were subjected to antimicrobial,
antifungal, and antimalarial susceptibility.

Conclusion:
From the above-obtained results, we have concluded that novel N-(2-aminophenyl)-2,3-
diphenylquinoxaline-6-sulfonamide derivatives have excellent potential to inhibit the receptorbinding
domain (RBD) of SARS-CoV-2 spike glycoprotein, which is now an attentive target in designing
SARS-CoV-2 inhibitors. This scaffold can hold an effective interest in the development of
inhibitors for SARS-CoV-2 in the future if drug repurposing fails to serve the purpose.
Comparative Study on Law Relating to Orthopedic Implants in India, the United States and European Union with Case Study
Authors: Duppala Lohithasu , Murthy Kolapalli Venkata Ramana 
Published: April 2021

Background:
The article provides a brief discussion on the comparative regulations on
orthopedic implants in India, the United States, and European Union. Orthopedic implants are type
of high-risk medical devices manufactured to substitute or replace a missing or damaged joint or
bone or to support a damaged bone or joint and to improve the quality of life of patients. Thus,
there is a need to regulate the import, manufacture, clinical investigation, sale, and distribution of
orthopedic implants to ensure that all orthopedic implants that were brought to market are safe quality
and performance. The orthopedic implants industry is adversely affected by a lack of awareness
of proper regulatory practices, lack of awareness of the current regulatory practices, separate consistent
standards, separate lawful requirements, and proper guidance on the quality system, etc.

Conclusion:
The objective of this article is to harmonize the regulatory requirements at par with
the internationally accepted regulations and to develop an ecosystem in the country to boost the Indian
orthopedic device sector, and that will make India more productive for orthopedic device development
to encourage national and multinational orthopedic implants industries to manufacture
their orthopedic implants in India.
Peran Komite Sekolah Dalam Peningkatan Mutu Pendidikan Madrasah
Authors: Ramli Ramli 
Published: April 2021

Abstract
One form of actualization in Indonesian education was the establishment of a body called School Committee that replaced the existence of the Education Organizing Body (BP3), stipulated through the Decree of the Minister of National Education No. 044/U/2002 dated April l2, 2002. The name of BP3 was changed into the School Committee due to the need of full community involvement in improving the quality of education. One of the objectives of the school committee is to increase the responsibility and participation of the community in the implementation of education in the education unit. In this present study, the focuses were on the process and the mechanism of the formation of the madrasah (Islamic school) committee organization, the planning carried out by the madrasah committee in improving the quality of madrasah education, and the implementation of the madrasah committee programs in improving the quality of education in Aceh Besar District. This study employed qualitative research methods. Data were collected through observation, interviews, and documentation. Findings showed that the process and the mechanism in forming the madrasah committee in Aceh Besar District were based on the decision of the Ministry of Education on the establishment of community-based organizations, including by mutual deliberations or meetings held every 3 years in a transparent, accountable, and democratic manner, and by involving the community as an education unit partner. Further, the planning of the madrasah committee in improving the quality of madrasah education was carried out by establishing the structure of the committee and holding regular meetings with madrasahs and the community every three months or at the end of each semester, and also by preparing and organizing religious and national holidays together with other madrasahs. In addition, the madrasah committee programs were well implemented in Aceh Besar, as seen from the involvement of all elements from both madrasahs as the organizers of the activities and the community as the provider of advice and input. The programs included the religious and the extracurricular programs in collaboration with the sub-districts and district of Aceh Besar.
Behavior of a draining mixture composed by recycled concrete aggregates and rubberized asphalt concrete
Authors: Bastidas-Martínez Juan Gabriel , Rodríguez-Joaquín Nicolás Infante , Torres-Daza Hernán Darío , Rondón-Quintana Hugo Alexander , Ruge-Cárdenas Juan Carlos 
Published: April 2021

Concrete waste is considered an environmental liability with a negative impact. However, this type of waste presents a high potential to be used as an alternative building material. Therefore, the present study aims to evaluate the applicability of substituting the conventional natural stone aggregate (CA) of a draining asphalt mixture (MD) by a recycled concrete aggregate (RCA). Firstly, RCA was physically characterized to be compared with the AC. Then, two MD mixtures were design with rubberized asphalt concrete (GCR by its spanish acronym): one using the conventional aggregate (control sample) and one with the RCA substituting entirely the CA. Experimental tests under monotonic load (indirect tensile strength - RTI) were conducted over the mixtures, as well as adhesion tests (susceptibility of RTI in wet and dry conditions and abrasion wear Cantabro). The results indicate that for MD mixtures with RCA, a higher content of asphalt is required than with CA. Additionally, it wasfound that the presence of higher asphalt content in MD-RCA mixtures increases its adhesion when compared with the control sample. Therefore, it can be concluded that the use the RCA for MD mixtures, in the proposed way, is technically and environmentally viable.
Un reencuentro entre la historia y la contabilidad
Authors: Cepeda-Torres Yuliana Andrea , López-Contreras Luz Eliana , Durán-Caicedo Luz Estela 
Published: April 2021

El presente trabajo tiene como objetivo analizar la historia de la contabilidad dentro de la evolución de la humanidad, así mismo se realizó un proceso de documental científico el cual toma diferentes tipos de documentos que le permite indagar sobre el tema teniendo presente los puntos de vista de cada uno de sus autores, el cual brindan datos e información que ayuda a recopilar y redescubrir ciertos momentos significativos que dieron paso a grandes descubrimientos, hechos que enfatizan cientos de años de recorrido de conocimientos y aprendizajes contundentes para la subsistencia de la vida misma; del mismo modo la contabilidad se ha visto como una herramienta sutil e incomparable con otras, dado que esta maneja principalmente la economía de una nación, sus progresos, el ámbito laboral de las personas para el sustento de sus familias, que se ha ido innovando desde hace más de 600 años, donde surgieron elementos como la escritura, los números , los conceptos de propiedad y la aceptación de una unidad de valor, que mostraron ser los factores más sobresalientes para la creación de un mundo extraordinario. Más aun revelaron la fórmula de ser mejores, de cómo las matemáticas, pueden ser un eje principal de esta columna que ha envuelto en un camino comercial, con ideas, formas de atraer la atención y prosperar, pero sobre todo que da una guía para no cometer errores y enseñar de una manera más compleja ese universo extraordinario que muchas veces los mismos estudiantes no comprender por el simple hecho de no querer conocerlo. Por consiguiente, estos momentos históricos permite conocer y analizar que todo esto se basó en la misma necesidad del hombre, dependiendo de la época, su cultura, sus pensadores que tomaron esta fuente como el devenir de un futuro exitoso.