bluuebunny/crossref_metadata_2025_split huggingface dataset:
HEADLESS MUSICAL SEEDS AND GESTURES WITH ADJECTIVES: AN INTERVIEW WITH KEIKO DEVAUX
Authors: Höstman Anna 
Published: December 2021

AbstractKeiko Devaux (b. 1982) is a Canadian composer, originally from British Columbia, who now lives in Montréal. She began her musical career in piano-performance studies as well as composing, touring and recording several albums in independent rock bands. Her concert music is widely performed throughout Canada and Europe. From 2016–18, Keiko was the composer in residence of Le Nouvel Ensemble Moderne. She joined Salvatore Sciarrino's masterclasses at L'Accademia Musicale Chigiana in Siena, Italy, between the years 2017 and 2019. Keiko was commissioned by music@villaromana festival, Florence, to create Echoic Memories. She is the inaugural winner of the Azrieli Commission for Canadian Music (2020) and is also engaged in a two-year residency as a Carrefour composer with the National Arts Centre Orchestra (2020–22). This interview was conducted over Zoom in late spring 2020, in the midst of the Covid-19 pandemic.
Numbers in action
Authors: Burr David C. , Anobile Giovanni , Castaldi Elisa , Arrighi Roberto 
Published: December 2021

Abstract
To understand the number sense, we need to understand its function. We argue that numerosity estimation is fundamental not only for perception, but also preparation and control of action. We outline experiments that link numerosity estimation with action, pointing to a generalized numerosity system that serves both perception and action preparation.
Weighted numbers
Authors: Marinova Mila , Fedele Marta , Reynvoet Bert 
Published: December 2021

Abstract
Clarke and Beck (C&B) discuss in their sections on congruency and confounds (sects. 3 and 4) literature that has challenged the claim that the approximate number system (ANS) represents numerical content. We argue that the propositions put forward by these studies aren't that far from the indirect model of number perception suggested by C&B.
The number sense does not represent numbers, but cardinality comparisons
Authors: Bermúdez José Luis 
Published: December 2021

Abstract
Against Clarke and Beck's proposal that the approximate number system (ANS) represents natural and rational numbers, I suggest that the experimental evidence is better accommodated by the (much weaker) thesis that the ANS represents cardinality comparisons. Cardinality comparisons do not stand in arithmetical relations and being able to apply them does not involve basic arithmetical concepts and operations.
Ratio-based perceptual foundations for rational numbers, and perhaps whole numbers, too?
Authors: Hubbard Edward M. , Matthews Percival G. 
Published: December 2021

Abstract
Clarke and Beck suggest that the ratio processing system (RPS) may be a component of the approximate number system (ANS), which they suggest represents rational numbers. We argue that available evidence is inconsistent with their account and advocate for a two-systems view. This implies that there may be many access points for numerical cognition – and that privileging the ANS may be a mistake.
Not so rational: A more natural way to understand the ANS
Authors: Hecht Eli , Mills Tracey , Shin Steven , Phillips Jonathan 
Published: December 2021

Abstract
In contrast to Clarke and Beck's claim that that the approximate number system (ANS) represents rational numbers, we argue for a more modest alternative: The ANS represents natural numbers, and there are separate, non-numeric processes that can be used to represent ratios across a wide range of domains, including natural numbers.
Constructing rationals through conjoint measurement of numerator and denominator as approximate integer magnitudes in tradeoff relations
Authors: Zhang Jun 
Published: December 2021

Abstract
To investigate mechanisms of rational representation, I consider (1) construction of an ordered continuum of psychophysical scale of magnitude of sensation; (2) counting mechanism leading to an approximate numerosity scale for integers; and (3) conjoint measurement structure pitting the denominator against the numerator in tradeoff positions. Number sense of resulting rationals is neither intuitive nor expedient in their manipulation.
Helping Refugees Where They Are
Authors: Gerver Mollie 
Published: December 2021

AbstractSome policies are not politically feasible. In the context of refugees, many claim it is not politically feasible to start admitting significantly more refugees into wealthy countries. In particular, it is not feasible for advocates of refugees to successfully persuade policymakers to adopt such a policy. A recent book by Alexander Betts argues that advocates should instead focus on developing the economies of lower-income countries where most refugees reside. This review essay argues that current data does not yet establish whether Betts's approach is more feasible than increasing refugee admissions to wealthy states. There are good reasons to suppose increasing refugees’ admissions to wealthy states is politically feasible, if we account for the ways citizens in wealthy states are harmed when refugees are not admitted, and for the ways citizens are harmed when immigration enforcement prevents refugees from arriving. Drawing on recent books on immigration, this essay demonstrates that enforcement against refugees constrains citizens’ freedom, well-being, and ability to hold their government to account. Further research can establish if citizens’ interest in reducing enforcement can be translated into policy changes that significantly increase the number of refugees admitted. Such research is necessary before concluding that only helping refugees in lower-income countries is feasible.
Treatment of chronic resistant paediatric idiopathic pericardial effusion with intrapericardial injection of corticosteroids 4-year-old girl with rapid full resolution after intrapericardial injection of corticosteroids
Authors: Othman Takhfif , Eldadah Osama 
Published: December 2021

AbstractNon-steroidal anti-inflammatory drugs are the conventional treatment for pericarditis. However, some patients will still suffer from persistence pericardial effusion despite exhausting all conventional management options. A 4-year-old girl with idiopathic pericardial effusion who did not respond to 2 months of conventional therapy had complete resolution of effusion within 5 days, with no recurrence after administration of intrapericardial steroids. As far as we know, this is the first published paediatric case who has shown a similar outcome to that seen in adult studies.
Concept-less Schemata: The Reciprocity of Imagination and Understanding in Kant’s Aesthetics
Authors: Filieri Luigi 
Published: December 2021

AbstractIn this paper, I discuss Kant’s concept-less schematism (KU, 5: 287) in the thirdCritique1and make three claims: 1) concept-less schematism is entirely consistent with the schematism in the firstCritique; 2) concept-less schematism is schematism with noempiricalconcept as an outcome; and 3) in accordance with 1) and 2), the imagination is free to synthesize the given manifold and leads to judgements of taste without this meaning either that the categories play no role at all or that these judgements are full-fledged cognitive determining judgements. While most commentators read the freedom of the imagination as its independence from the understanding, I argue that the freedom of the imagination is based on a non-determining employment of the pure concepts of the understanding. The freedom of the aesthetic imagination consists in the temporal schematization of the categories without any complementary determination of the empirical concept.
Spatiotemporal Characterization of Geophysical Signal Detection Capabilities of GRACE‐FO
Authors: Peidou Athina , Landerer Felix , Wiese David , Ellmer Matthias , Fahnestock Eugene , McCullough Christopher , Spero Robert , Yuan Dah‐Ning 
Published: December 2021

AbstractThe intersatellite range measurements between the Gravity Recovery and Climate Experiment Follow‐On (GRACE‐FO) satellite pair enable mapping time variations in Earth's gravity field. The Laser Ranging Interferometer (LRI) and Microwave Instrument (MWI) provide independent range measurements. We compare gravity fields derived from the two instruments. The LRI captures time‐variable gravity field signals up to 21 mHz (165 km half‐wavelength) globally, while MWI reaches frequencies up to 15 mHz (230 km). Time‐variable mass variations free from annual cycles and trends are sensed up to 15 mHz (LRI) and 11 mHz (320 km) (MWI). Both instruments are shown to be excellent tools for detection and monitoring of sub‐monthly geophysical signals. Along‐track global maps of sub‐monthly signals are expected to shed light on the high‐frequency behavior of a large number of geophysical processes.
A schizophrenia subgroup with elevated inflammation displays reduced microglia, increased peripheral immune cell and altered neurogenesis marker gene expression in the subependymal zone
Authors: North Hayley F. , Weissleder Christin , Fullerton Janice M. , Sager Rachel , Webster Maree J. , Weickert Cynthia Shannon 
Published: December 2021

AbstractInflammation regulates neurogenesis, and the brains of patients with schizophrenia and bipolar disorder have reduced expression of neurogenesis markers in the subependymal zone (SEZ), the birthplace of inhibitory interneurons. Inflammation is associated with cortical interneuron deficits, but the relationship between inflammation and reduced neurogenesis in schizophrenia and bipolar disorder remains unexplored. Therefore, we investigated inflammation in the SEZ by defining those with low and high levels of inflammation using cluster analysis of IL6, IL6R, IL1R1 and SERPINA3 gene expression in 32 controls, 32 schizophrenia and 29 bipolar disorder cases. We then determined whether mRNAs for markers of glia, immune cells and neurogenesis varied with inflammation. A significantly greater proportion of schizophrenia (37%) and bipolar disorder cases (32%) were in high inflammation subgroups compared to controls (10%, p < 0.05). Across the high inflammation subgroups of psychiatric disorders, mRNAs of markers for phagocytic microglia were reduced (P2RY12, P2RY13), while mRNAs of markers for perivascular macrophages (CD163), pro-inflammatory macrophages (CD64), monocytes (CD14), natural killer cells (FCGR3A) and adhesion molecules (ICAM1) were increased. Specific to high inflammation schizophrenia, quiescent stem cell marker mRNA (GFAPD) was reduced, whereas neuronal progenitor (ASCL1) and immature neuron marker mRNAs (DCX) were decreased compared to low inflammation control and schizophrenia subgroups. Thus, a heightened state of inflammation may dampen microglial response and recruit peripheral immune cells in psychiatric disorders. The findings elucidate differential neurogenic responses to inflammation within psychiatric disorders and highlight that inflammation may impair neuronal differentiation in the SEZ in schizophrenia.
Androgen receptor and MYC equilibration centralizes on developmental super-enhancer
Authors: Guo Haiyang , Wu Yiming , Nouri Mannan , Spisak Sandor , Russo Joshua W. , Sowalsky Adam G. , Pomerantz Mark M. , Wei Zhao , Korthauer Keegan , Seo Ji-Heui , Wang Liyang , Arai Seiji , Freedman Matthew L. , He Housheng Hansen , Chen Shaoyong , Balk Steven P. 
Published: December 2021

AbstractAndrogen receptor (AR) in prostate cancer (PCa) can drive transcriptional repression of multiple genes including MYC, and supraphysiological androgen is effective in some patients. Here, we show that this repression is independent of AR chromatin binding and driven by coactivator redistribution, and through chromatin conformation capture methods show disruption of the interaction between the MYC super-enhancer within the PCAT1 gene and the MYC promoter. Conversely, androgen deprivation in vitro and in vivo increases MYC expression. In parallel, global AR activity is suppressed by MYC overexpression, consistent with coactivator redistribution. These suppressive effects of AR and MYC are mitigated at shared AR/MYC binding sites, which also have markedly higher levels of H3K27 acetylation, indicating enrichment for functional enhancers. These findings demonstrate an intricate balance between AR and MYC, and indicate that increased MYC in response to androgen deprivation contributes to castration-resistant PCa, while decreased MYC may contribute to responses to supraphysiological androgen therapy.
Modular and stereoselective synthesis of tetrasubstituted vinyl sulfides leading to a library of AIEgens
Authors: Liu Xun-Shen , Tang Zhiqiong , Li Zhiming , Li Mingjia , Xu Lin , Liu Lu 
Published: December 2021

AbstractTetraarylethylenes exhibit intriguing photophysical properties and sulfur atom frequently play a vital role in organic photoelectric materials and biologically active compounds. Tetrasubstituted vinyl sulfides, which include both sulfur atom and tetrasubstituted alkenes motifs, might be a suitable skeleton for the discovery of the new material molecules and drug with unique functions and properties. However, how to modular synthesis these kinds of compounds is still challenging. Herein, a chemo- and stereo-selective Rh(II)-catalyzed [1,4]-acyl rearrangements of α-diazo carbonyl compounds and thioesters has been developed, providing a modular strategy to a library of 63 tetrasubstituted vinyl sulfides. In this transformation, the yield is up to 95% and the turnover number is up to 3650. The mechanism of this reaction is investigated by combining experiments and density functional theory calculation. Moreover, the “aggregation-induced emission” effect of tetrasubstituted vinyl sulfides were also investigated, which might useful in functional material, biological imaging and chemicalnsing via structural modification.
Live tumor imaging shows macrophage induction and TMEM-mediated enrichment of cancer stem cells during metastatic dissemination
Authors: Sharma Ved P. , Tang Binwu , Wang Yarong , Duran Camille L. , Karagiannis George S. , Xue Emily A. , Entenberg David , Borriello Lucia , Coste Anouchka , Eddy Robert J. , Kim Gina , Ye Xianjun , Jones Joan G. , Grunblatt Eli , Agi Nathan , Roy Sweta , Bandyopadhyaya Gargi , Adler Esther , Surve Chinmay R. , Esposito Dominic , Goswami Sumanta , Segall Jeffrey E. , Guo Wenjun , Condeelis John S. , Wakefield Lalage M. , Oktay Maja H. 
Published: December 2021

AbstractCancer stem cells (CSCs) play an important role during metastasis, but the dynamic behavior and induction mechanisms of CSCs are not well understood. Here, we employ high-resolution intravital microscopy using a CSC biosensor to directly observe CSCs in live mice with mammary tumors. CSCs display the slow-migratory, invadopod-rich phenotype that is the hallmark of disseminating tumor cells. CSCs are enriched near macrophages, particularly near macrophage-containing intravasation sites called Tumor Microenvironment of Metastasis (TMEM) doorways. Substantial enrichment of CSCs occurs on association with TMEM doorways, contributing to the finding that CSCs represent >60% of circulating tumor cells. Mechanistically, stemness is induced in non-stem cancer cells upon their direct contact with macrophages via Notch-Jagged signaling. In breast cancers from patients, the density of TMEM doorways correlates with the proportion of cancer cells expressing stem cell markers, indicating that in human breast cancer TMEM doorways are not only cancer cell intravasation portals but also CSC programming sites.
Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis
Authors: Ramchandani Divya , Berisa Mirela , Tavarez Diamile A. , Li Zhuoning , Miele Matthew , Bai Yang , Lee Sharrell B. , Ban Yi , Dephoure Noah , Hendrickson Ronald C. , Cloonan Suzanne M. , Gao Dingcheng , Cross Justin R. , Vahdat Linda T. , Mittal Vivek 
Published: December 2021

AbstractCopper serves as a co-factor for a host of metalloenzymes that contribute to malignant progression. The orally bioavailable copper chelating agent tetrathiomolybdate (TM) has been associated with a significant survival benefit in high-risk triple negative breast cancer (TNBC) patients. Despite these promising data, the mechanisms by which copper depletion impacts metastasis are poorly understood and this remains a major barrier to advancing TM to a randomized phase II trial. Here, using two independent TNBC models, we report a discrete subpopulation of highly metastatic SOX2/OCT4+ cells within primary tumors that exhibit elevated intracellular copper levels and a marked sensitivity to TM. Global proteomic and metabolomic profiling identifies TM-mediated inactivation of Complex IV as the primary metabolic defect in the SOX2/OCT4+ cell population. We also identify AMPK/mTORC1 energy sensor as an important downstream pathway and show that AMPK inhibition rescues TM-mediated loss of invasion. Furthermore, loss of the mitochondria-specific copper chaperone, COX17, restricts copper deficiency to mitochondria and phenocopies TM-mediated alterations. These findings identify a copper-metabolism-metastasis axis with potential to enrich patient populations in next-generation therapeutic trials.
Spin-dependent vibronic response of a carbon radical ion in two-dimensional WS2
Authors: Cochrane Katherine A. , Lee Jun-Ho , Kastl Christoph , Haber Jonah B. , Zhang Tianyi , Kozhakhmetov Azimkhan , Robinson Joshua A. , Terrones Mauricio , Repp Jascha , Neaton Jeffrey B. , Weber-Bargioni Alexander , Schuler Bruno 
Published: December 2021

AbstractAtomic spin centers in 2D materials are a highly anticipated building block for quantum technologies. Here, we demonstrate the creation of an effective spin-1/2 system via the atomically controlled generation of magnetic carbon radical ions (CRIs) in synthetic two-dimensional transition metal dichalcogenides. Hydrogenated carbon impurities located at chalcogen sites introduced by chemical doping are activated with atomic precision by hydrogen depassivation using a scanning probe tip. In its anionic state, the carbon impurity is computed to have a magnetic moment of 1 μB resulting from an unpaired electron populating a spin-polarized in-gap orbital. We show that the CRI defect states couple to a small number of local vibrational modes. The vibronic coupling strength critically depends on the spin state and differs for monolayer and bilayer WS2. The carbon radical ion is a surface-bound atomic defect that can be selectively introduced, features a well-understood vibronic spectrum, and is charge state controlled.
Liver MRI and clinical findings to predict response after drug eluting bead transarterial chemoembolization in hepatocellular carcinoma
Authors: Lee Jeong Yeop , Lee Byung Chan , Kim Hyoung Ook , Heo Suk Hee , Shin Sang Soo , Jeong Yong Yeon 
Published: December 2021

AbstractTo identify the gadoxetic acid (GA)-enhanced magnetic resonance imaging (MRI) and laboratory findings that enable prediction of treatment response and disease-free survival (DFS) after the first session of drug eluting bead transarterial chemoembolization (DEB-TACE) in patients with hepatocellular carcinoma (HCC). A total of 55 patients who underwent GA-enhanced MRI and DEB-TACE from January 2014 to December 2018 were included. All MRI features were reviewed by two radiologists. Treatment response was evaluated according to the modified Response Evaluation Criteria in Solid Tumors. Univariate and multivariate logistic regression analyses were used to determine predictive factors of treatment response and DFS, respectively. A total of 27 patients (49.1%) achieved complete response (CR) after one session of treatment. There were no significant differences between the two groups in terms of clinical and laboratory characteristics. Heterogeneous signal intensity in the hepatobiliary phase (HBP) was the only independent predictor of non-CR (odds ratio, 4.807; p = 0.048). Recurrent HCC was detected in 19 patients (70.4%) after CR. In the multivariate analysis, elevated serum alpha-fetoprotein (AFP) level (≥ 30 ng/mL) was the only significant parameter associated with DFS (hazard ratio, 2.916; p = 0.040). This preliminary study demonstrated that heterogeneous signal intensity in the HBP and high serum AFP were useful predictive factors for poor treatment response and short DFS after DEB-TACE, respectively.
Development and validation of a practical machine-learning triage algorithm for the detection of patients in need of critical care in the emergency department
Authors: Liu Yecheng , Gao Jiandong , Liu Jihai , Walline Joseph Harold , Liu Xiaoying , Zhang Ting , Wu Yunyang , Wu Ji , Zhu Huadong , Zhu Weiguo 
Published: December 2021

AbstractIdentifying critically ill patients is a key challenge in emergency department (ED) triage. Mis-triage errors are still widespread in triage systems around the world. Here, we present a machine learning system (MLS) to assist ED triage officers better recognize critically ill patients and provide a text-based explanation of the MLS recommendation. To derive the MLS, an existing dataset of 22,272 patient encounters from 2012 to 2019 from our institution’s electronic emergency triage system (EETS) was used for algorithm training and validation. The area under the receiver operating characteristic curve (AUC) was 0.875 ± 0.006 (CI:95%) in retrospective dataset using fivefold cross validation, higher than that of reference model (0.843 ± 0.005 (CI:95%)). In the prospective cohort study, compared to the traditional triage system’s 1.2% mis-triage rate, the mis-triage rate in the MLS-assisted group was 0.9%. This MLS method with a real-time explanation for triage officers was able to lower the mis-triage rate of critically ill ED patients.
Identification of molecular subtypes and prognostic signature for hepatocellular carcinoma based on genes associated with homologous recombination deficiency
Authors: Lin Hongsheng , Xie Yangyi , Kong Yinzhi , Yang Li , Li Mingfen 
Published: December 2021

AbstractHepatocellular carcinoma (HCC) is a rapidly developing digestive tract carcinoma. The prognosis of patients and side effects caused by clinical treatment should be better improved. Nonnegative matrix factorization (NMF) clustering was performed using 109 homologous recombination deficiency (HRD)-related of HCC genes from The Cancer Genome Atlas (TCGA) database. Limma was applied to analyze subtype differences. Immune scores and clinical characteristics of different subtypes were compared. An HRD signature were built with least absolute shrinkage operator (LASSO) and multivariate Cox analysis. Performance of the signature system was then assessed by Kaplan–Meier curves and receiver operating characteristic (ROC) curves. We identified two molecular subtypes (C1 and C2), with C2 showing a significantly better prognosis than C1. C1 contained 3623 differentially expressed genes. A 4-gene prognostic signature for HCC was established, and showed a high predicting accuracy in validation sets, entire TCGA data set, HCCDB18 and GSE14520 queues. Moreover, the risk score was validated as an independent prognostic marker for HCC. Our research identified two molecular subtypes of HCC, and proposed a novel scoring system for evaluating the prognosis of HCC in clinical practice.