bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Advances on Conductive 2D Covalent Organic Frameworks
Authors: Bian Gang , Yin Jun , Zhu Jian 
Published: February 2021

AbstractAs a burgeoning family of crystalline porous copolymers, covalent organic frameworks (COFs) allow precise atomic insertion of organic components in the topology construction to form periodic networks and ordered nanopores. Their 2D networks bear great similarities to graphene analogs, and therefore are essential additions to the 2D family. Here, the electronic properties of conductive 2D‐COFs are reviewed and their bonding strategies and structural characteristics are examined in detail. The controlling approaches toward the morphologies of conductive 2D‐COFs are further explored, followed by a discussion of their applications in field‐effect transistors, photodetectors, sensors, catalysis, and energy storage. Finally, research challenges and forthcoming developments are projected. The resulting survey reveals that the extended porous 2D organic networks with conductive properties will provide great opportunities and essential innovations in various electronics and energy‐related fields.
Directly Probing the Local Coordination, Charge State, and Stability of Single Atom Catalysts by Advanced Electron Microscopy: A Review
Authors: Tieu Peter , Yan Xingxu , Xu Mingjie , Christopher Phillip , Pan Xiaoqing 
Published: February 2021

AbstractThe drive for atom efficient catalysts with carefully controlled properties has motivated the development of single atom catalysts (SACs), aided by a variety of synthetic methods, characterization techniques, and computational modeling. The distinct capabilities of SACs for oxidation, hydrogenation, and electrocatalytic reactions have led to the optimization of activity and selectivity through composition variation. However, characterization methods such as infrared and X‐ray spectroscopy are incapable of direct observations at atomic scale. Advances in transmission electron microscopy (TEM) including aberration correction, monochromators, environmental TEM, and micro‐electro‐mechanical system based in situ holders have improved catalysis study, allowing researchers to peer into regimes previously unavailable, observing critical structural and chemical information at atomic scale. This review presents recent development and applications of TEM techniques to garner information about the location, bonding characteristics, homogeneity, and stability of SACs. Aberration corrected TEM imaging routinely achieves sub‐Ångstrom resolution to reveal the atomic structure of materials. TEM spectroscopy provides complementary information about local composition, chemical bonding, electronic properties, and atomic/molecular vibration with superior spatial resolution. In situ/operando TEM directly observe the evolution of SACs under reaction conditions. This review concludes with remarks on the challenges and opportunities for further development of TEM to study SACs.
Selective Cocatalyst Deposition on ZnTiO3−xNy Hollow Nanospheres with Efficient Charge Separation for Solar‐Driven Overall Water Splitting
Authors: Wei Shunhang , Chang Shufang , Qian Jun , Xu Xiaoxiang 
Published: February 2021

AbstractPt and RhOx cocatalysts are selectively deposited at inner and outer surface of ZnTiO3−xNy hollow nanospheres, respectively. The resulting photocatalytic systems exhibit promising activity for photocatalytic overall water splitting with stoichiometric H2/O2 ratio under simulated solar insolation. Selective deposition of Pt and RhOx cocatalysts at different surfaces not only mitigates back reactions of the products but also induces strong potential gradient within nanospheres that promotes efficient dissociation and fast migration of photocarriers to the surface.
A pathological analysis of challenges related to systems thinking studies in Iran
Authors: Kharazmi Omid Ali , Kharazmi Amirali 
Published: February 2021

AbstractThe present study aimed at conducting a pathological analysis of challenges related to systems thinking studies in Iran. The data were obtained through 18 in‐depth interviews. These individuals were selected through snowball sampling. Results showed that among the major challenges of implementing this method are deficiencies of training and awareness raising about systems thinking in organizations and society, issues related to methodology and analytical tools, low degree of research consistency with the needs of the society and deficiencies in knowledge sharing and networking. Among the major recommendations for resolving the aforementioned challenges are defining the aim, scope, communication pattern and potential challenges related to interdisciplinary and multidisciplinary projects at the beginning, holding training workshops and forming knowledge networks on national and international levels, raising awareness and knowledge of employees about systems thinking at different levels of organizations and encouraging researchers to choose topics that are of interest to beneficiary organizations.
Case study of a SAP‐CRC bridge deck in Lu‐shan County, Henan, China
Authors: Shi Wan‐wan , Zhu Han , Yu Yong , Luo Chuang‐dan , Shan Ji , Wang Ting 
Published: February 2021

AbstractThree‐Mile‐River Bridge is located in Lu‐shan County, Henan, China. The bridge length is 80 m and width is 17.25 m with the deck thickness being 0.3 m. The deck construction is finished in June 2018, which consumed 200 cubic meter of crumb rubber concrete (CRC) with added super‐absorbent polymer (SAP), and opens for traffic in July 2018. This is the first case of SAP‐CRC bridge deck reported to the public with “pump concrete” technical being employed. The scanning of SAP‐CRC samples taken from the job site shows that rubber crumbs are largely uniformly distributed. The free restrained test on SAP‐CRC concrete and the test of restrained externally squared eccentric ring experiment on the mortar specimens made by filtering 10 mm coarse crumbs out of paving concrete show that SAP‐CRC exhibits an improved property in shrinkage behavior and cracking resistance. The original deck design is a three‐layer configuration: 0.3 m concrete + water approval sealing + 0.03 m hot mix asphalt. Consider CRC's excellence in preventing cracking, the sealing, and hot mix asphalt is removed, which results in a 10% reduction in construction cost and time. It is a technical success to add SAP into fresh CRC to suppress so called “rubber particle up‐floating phenomenon,” as well as an engineering/commercial success in the sense that this deck project is implemented following common practices of commercial construction operation and cost‐saving, which sets an case study to future similar applications that potentially will consume large quantity, if not all, of recycled rubbers from scrap tires worldwide.
Extremely Low‐Frequency Electric Field Exposure Increases Theta Power of EEG in both Eyes‐Open and Eyes‐Closed Resting Conditions in Healthy Male Subjects
Authors: Shinba Toshikazu , Nedachi Takaki , Harakawa Shinji 
Published: February 2021

The effects of extremely low‐frequency (ELF) electric field (EF) exposure on brain activity remain poorly understood. This study sought to examine the acute effects of EF exposure on brain activity by analyzing electroencephalogram (EEG) basic rhythms. The heart rate variability (HRV) was also measured to evaluate autonomic activity. Using a system that enables measurement under EF exposure, occipital EEG and electrocardiogram signals were recorded in nine healthy male subjects during daytime in eyes‐open and eyes‐closed conditions, with or without EF exposure (applied voltage: 30 kV, 50 Hz for 1 min). The EEG power and frequency‐domain HRV indices were obtained by power spectrum analysis of EEG and the RR interval trend, respectively. Resulting data revealed that the theta power of EEG was significantly greater during EF exposure in eyes‐open and eyes‐closed conditions. Other EEG rhythms and HRV indices were not affected by EF exposure. These findings suggest that exposure to 50‐Hz EF for 1 min altered brain activity by increasing the theta power. © 2021 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.
Confound Removal and Normalization in Practice: A Neuroimaging Based Sex Prediction Case Study
Authors: More Shammi , Eickhoff Simon B. , Caspers Julian , Patil Kaustubh R. 
Published: February 2021

Abstract
Machine learning (ML) methods are increasingly being used to predict pathologies and biological traits using neuroimaging data. Here controlling for confounds is essential to get unbiased estimates of generalization performance and to identify the features driving predictions. However, a systematic evaluation of the advantages and disadvantages of available alternatives is lacking. This makes it difficult to compare results across studies and to build deployment quality models. Here, we evaluated two commonly used confound removal schemes–whole data confound regression (WDCR) and cross-validated confound regression (CVCR)–to understand their effectiveness and biases induced in generalization performance estimation. Additionally, we study the interaction of the confound removal schemes with Z-score normalization, a common practice in ML modelling. We applied eight combinations of confound removal schemes and normalization (pipelines) to decode sex from resting-state functional MRI (rfMRI) data while controlling for two confounds, brain size and age. We show that both schemes effectively remove linear univariate and multivariate confounding effects resulting in reduced model performance with CVCR providing better generalization estimates, i.e., closer to out-of-sample performance than WDCR. We found no effect of normalizing before or after confound removal. In the presence of dataset and confound shift, four tested confound removal procedures yielded mixed results, raising new questions. We conclude that CVCR is a better method to control for confounding effects in neuroimaging studies. We believe that our in-depth analyses shed light on choices associated with confound removal and hope that it generates more interest in this problem instrumental to numerous applications.
Lessons from the study of plant mating systems for exploring the causes and consequences of inbreeding in marine invertebrates
Authors: Olsen Kevin C. , Ryan Will H. , Kosman Ellen T. , Moscoso Jose A. , Levitan Don R. , Winn Alice A. 
Published: February 2021

AbstractMany benthic marine invertebrates resemble plants in being modular and either sessile or sedentary, and by relying on an external vector to disperse their gametes. These shared features, along with recent evidence of inbreeding in these taxa, suggest that theory and practice bearing on the evolutionary costs and benefits of inbreeding for plants could advance our understanding of the ecology and evolution of invertebrate animals. We describe how the theory for the evolution of inbreeding and outbreeding could apply to benthic invertebrates, identify and compare techniques used to quantify inbreeding in plants and animals, translate relevant botanical concepts and empirical patterns to their zoological equivalents, and articulate predictions for how inbreeding might be associated with major axes of variation in sessile and sedentary marine invertebrates. The theory of inbreeding and outbreeding provides critical insight into major patterns of life-history variation in plants and holds similar promise as a complementary perspective on the evolution of reproductive traits, lifespan, ecological strategies, and dispersal in marine invertebrates. Extending what we have learned from plants to marine invertebrates promises to broaden the general study of mating systems.
Modifications of diketopiperazines assembled by cyclodipeptide synthases with cytochrome P450 enzymes
Authors: Harken Lauritz , Li Shu-Ming 
Published: February 2021

Abstract2,5-Diketopiperazines are the smallest cyclic peptides comprising two amino acids connected via two peptide bonds. They can be biosynthesized in nature by two different enzyme families, either by nonribosomal peptide synthetases or by cyclodipeptide synthases. Due to the stable scaffold of the diketopiperazine ring, they can serve as precursors for further modifications by different tailoring enzymes, such as methyltransferases, prenyltransferases, oxidoreductases like cyclodipeptide oxidases, 2-oxoglutarate-dependent monooxygenases and cytochrome P450 enzymes, leading to the formation of intriguing secondary metabolites. Among them, cyclodipeptide synthase-associated P450s attracted recently significant attention, since they are able to catalyse a broader variety of astonishing reactions than just oxidation by insertion of an oxygen. The P450-catalysed reactions include hydroxylation at a tertiary carbon, aromatisation of the diketopiperazine ring, intramolecular and intermolecular carbon-carbon and carbon-nitrogen bond formation of cyclodipeptides and nucleobase transfer reactions. Elucidation of the crystal structures of three P450s as cyclodipeptide dimerases provides a structural basis for understanding the reaction mechanism and generating new enzymes by protein engineering. This review summarises recent publications on cyclodipeptide modifications by P450s.Key Points• Intriguing reactions catalysed by cyclodipeptide synthase-associated cytochrome P450s• Homo- and heterodimerisation of diketopiperazines• Coupling of guanine and hypoxanthine with diketopiperazines
Graphical abstract
High efficacy of BGD (bendamustine, gemcitabine, and dexamethasone) in relapsed/refractory Hodgkin Lymphoma
Authors: Swoboda Ryszard , Giebel Sebastian , Knopińska-Posłuszny Wanda , Chmielowska Ewa , Drozd-Sokołowska Joanna , Paszkiewicz-Kozik Ewa , Kulikowski Waldemar , Taszner Michał , Mendrek Włodzimierz , Najda Jacek , Czerw Tomasz , Olszewska-Szopa Magdalena , Czyż Anna , Giza Agnieszka , Spychałowicz Wojciech , Subocz Edyta , Szwedyk Paweł , Krzywon Aleksandra , Wilk Agata , Zaucha Jan Maciej 
Published: February 2021

AbstractThe optimal salvage therapy in relapsed/refractory Hodgkin lymphoma (R/R HL) has not been defined so far. The goal of this multicenter retrospective study was to evaluate efficacy and safety of BGD (bendamustine, gemcitabine, dexamethasone) as a second or subsequent line of therapy in classical R/R HL. We have evaluated 92 consecutive R/R HL patients treated with BGD. Median age was 34.5 (19–82) years. Fifty-eight patients (63%) had received 2 or more lines of chemotherapy, 32 patients (34.8%) radiotherapy, and 21 patients (22.8%) an autologous hematopoietic stem cell transplantation (autoHCT). Forty-four patients (47.8%) were resistant to first line of chemotherapy. BGD therapy consisted of bendamustine 90 mg/m2 on days 1 and 2, gemcitabine 800 mg/m2 on days 1 and 4, dexamethasone 40 mg on days 1–4. Median number of BGD cycles was 4 (2–7). The following adverse events ≥ 3 grade were noted: neutropenia (22.8%), thrombocytopenia (20.7%), anemia (15.2%), infections (10.9%), AST/ALT increase (2.2%), and skin rush (1.1%). After BGD therapy, 51 (55.4%) patients achieved complete remission, 23 (25%)—partial response, 7 (7.6%)—stable disease, and 11 (12%) patients experienced progression disease. AutoHCT was conducted in 42 (45.7%) patients after BGD therapy, and allogeneic HCT (alloHCT) in 16 (17.4%) patients. Median progression-free survival was 21 months. BGD is a highly effective, well-tolerated salvage regimen for patients with R/R HL, providing an excellent bridge to auto- or alloHCT.
Lateral trochlear lengthening osteotomy
Authors: Ismailidis Petros , Egloff Christian , Nüesch Corina , Mündermann Annegret , Pagenstert Geert 
Published: February 2021

Abstract
Introduction
The purpose of this study was to describe the indications and technical aspects as well as evaluate the clinical and functional outcome of lengthening osteotomy of the lateral trochlear ridge in patients with patellofemoral pain and/or patella instability and presence of trochlear dysplasia Dejour type A or lack of Dejour type dysplasia and short lateral articular trochlea.

Materials and methods
Six consecutive adult patients were treated with a lateral trochlear lengthening osteotomy. Five patients received a concomitant medial patellofemoral ligament reconstruction. Three patients had prior patella stabilization surgeries. Trochlea dysplasia (Dejour classification), Caton–Dechamps index, tibial tubercle trochlear groove (TT-TG) distance, patellar tilt and lateral condylar index were measured in preoperative MRIs. Clinical and functional evaluation included the Kujala Anterior Knee Pain Scale, the Lysholm Knee Score, the Tegner Activity Score, a subjective evaluation form and isokinetic muscle strength.

Results
Four patients had a Dejour type A dysplasia, two patients had no dysplasia. The mean (range) Caton-Dechamps index was 1.09 (0.95–1.16), TT-TG distance 10.9 mm (9.2–15.6 mm), patellar tilt 15° (4–32°) and lateral condylar index 82.0% (74–90%). One patient was lost to follow up, all others were followed for 2–5 years. All patients were satisfied with the clinical outcome. The Lysholm score increased from 55 (37–79) to 89 (76–100), the Tegner activity score from 3.6 (2–6) to 5.6 (5–7). The Kujala score postoperative was 90 (75–96). Some but not all patients had full strength recovery compared to the contralateral leg.

Conclusion
We recommend measuring the lateral condylar index and considering the indication of a lateral trochlear lengthening osteotomy as an additional or isolated procedure in selected patients with trochlear dysplasia Dejour type A or lack of dysplasia and short lateral articular trochlea depending on the extent of the patellar instability.

Level of evidence
Level IV, Case Series.

Trial registration number
NCT04378491, clinicaltrials.gov, May 7, 2020.
Ozone uptake at night is more damaging to plants than equivalent day-time flux
Authors: Goumenaki Eleni , González-Fernández Ignacio , Barnes Jeremy D. 
Published: February 2021

Abstract
Main conclusion
Plants exposed to equivalent ozone fluxes administered during day-time versus night-time exhibited greater losses in biomass at night and this finding is attributed to night-time depletion of cell wall-localised ascorbate.

Abstract
The present study employed Lactuca sativa and its closest wild relative, L. serriola, to explore the relative sensitivity of plants to ozone-induced oxidative stress during day-time versus night-time. By controlling atmospheric ozone concentration and measuring stomatal conductance, equivalent ozone uptake into leaves was engineered during day and night, and consequences on productivity and net CO2 assimilation rate were determined. Biomass losses attributable to ozone were significantly greater when an equivalent dose of ozone was taken-up by foliage at night compared to the day. Linkages between ozone impacts and ascorbic acid (AA) content, redox status and cellular compartmentation were probed in both species. Leaf AA pools were depleted by exposure of plants to darkness, and then AA levels in the apoplast and symplast were monitored on subsequent transfer of plants to the light. Apoplast AA appeared to be more affected by light–dark transition than the symplast pool. Moreover, equivalent ozone fluxes administered to leaves with contrasting AA levels resulted in contrasting effects on the light-saturated rate of CO2 assimilation (Asat) in both species. Once apoplast AA content recovered to pre-treatment levels, the same ozone flux resulted in no impacts on Asat. The results of the present investigation reveal that plants are significantly more sensitive to equivalent ozone fluxes taken-up at night compared with those during the day and were consistent with diel shifts in apoplast AA content and/or redox status. Furthermore, findings suggest that some thought should be given to weighing regional models of ozone impacts for extraordinary night-time ozone impacts.
Research activity amongst DCM research priorities
Authors: Grodzinski Ben , Bestwick Harry , Bhatti Faheem , Durham Rory , Khan Maaz , Partha Sarathi Celine Iswarya , Teh Jye Quan , Mowforth Oliver , Davies Benjamin 
Published: February 2021

Abstract
Introduction
Degenerative cervical myelopathy (DCM) is a progressive neurodegenerative disorder. DCM is common (estimated prevalence, 2% of adults) and significantly impacts quality of life. The AO Spine RECODE-DCM (Research Objectives and Common Data Elements in DCM) project has recently established the top research priorities for DCM. This article examines the extent to which existing research activity aligns with the established research priorities.

Methods
A systematic review of MEDLINE and Embase for “Cervical” AND “Myelopathy” was conducted following PRISMA guidelines. Full-text papers in English, exclusively studying DCM, published between January 1, 1995 and August 08, 2020 were considered eligible. Extracted data for each study included authors, journal, year of publication, location, sample size and study design. Each study was then analysed for alignment to the established research priorities.

Results
In total, 2261 papers with a total of 1,323,979 patients were included. Japan published more papers (625) than any other country. Moreover, 2005 (89%) of 2261 papers were aligned to at least one research priority. The alignment of papers to the different research priorities was unequal, with 1060 papers on the most researched priority alone (#15, predictors of outcome after treatment), but only 64 total papers on the least-researched 10 priorities. The comparative growth of research in the different priorities was also unequal, with some priorities growing and others plateauing over the past 5 years.

Discussion
Research activity in DCM continues to grow, and the focus of this research remains on surgery. The established research priorities therefore represent a new direction for the field.
Inside the failure mechanism of tin oxide as anode for sodium ion batteries
Authors: Spada Daniele , Davino Stefania , Girella Alessandro , Milanese Chiara , Bini Marcella 
Published: February 2021

AbstractThe conversion-alloying compounds have been identified as promising anode materials for sodium ion batteries (SIBs). One of them, SnO2, with an enormous theoretical capacity of 1558 mAh g−1 is an interesting candidate, also due to its low cost, environmental friendliness and wide availability of tin. However, many drawbacks limit its application in commercial batteries. In this paper, SnO2 has been synthesized from cheap reagents by using simple and easily scalable coprecipitation synthesis routes obtaining nanoparticles with sizes between 2 and 14 nm with almost spherical morphologies. The reasons of the failure of the alloying/de-alloying process were investigated by combining the results obtained from common electrochemical techniques, providing useful examples for the investigation of every material with analogous electrochemical features. Thanks to cyclic voltammetry, different reaction paths were detected for the two samples. The first cycle irreversibility was well characterized with electrochemical impedance spectroscopy, showing interesting trends in the values of the resistance. Galvanostatic cycling with potential limitations was employed to quantify the irreversibility, finding out that the most crystalline sample reached the terminal phase in the Sn-Na system (Na15Sn4), while the least crystalline sample could not achieve such a result (Na3Sn). The crystallinity of SnO2 was determined to be a key parameter, often neglected, for the realization of satisfactory anode compounds.