bluuebunny/crossref_metadata_2025_split huggingface dataset:
CDON gene contributes to pituitary stalk interruption syndrome associated with unilateral facial and abducens nerve palsy
Authors: Obara-Moszyńska Monika , Budny Bartłomiej , Kałużna Małgorzata , Zawadzka Katarzyna , Jamsheer Aleksander , Rohde Anna , Ruchała Marek , Ziemnicka Katarzyna , Niedziela Marek 
Published: July 2021

AbstractThe relationship between congenital defects of the brain and facial anomalies was proven. The Hedgehog signaling pathway plays a fundamental role in normal craniofacial development in humans. Mutations in the sonic hedgehog (SHH) signaling gene CDON have been recently reported in patients with holoprosencephaly and with pituitary stalk interruption syndrome (PSIS). This study’s aim was an elucidation of an 18-year-old patient presenting PSIS, multiple pituitary hormone deficiency, and congenital unilateral facial and abducens nerve palsy. Additionally, bilateral sensorineural hearing loss, dominating at the right site, was diagnosed. From the second year of life, growth deceleration was observed, and from the age of eight, anterior pituitary hormone deficiencies were gradually confirmed and substituted. At the MRI, characteristic triad for PSIS (anterior pituitary hypoplasia, interrupted pituitary stalk and ectopic posterior lobe) was diagnosed. We performed a comprehensive genomic screening, including microarrays for structural rearrangements and whole-exome sequencing for a monogenic defect. A novel heterozygous missense variant in the CDON gene (c.1814G > T; p.Gly605Val) was identified. The variant was inherited from the mother, who, besides short stature, did not show any disease symptoms. The variant was absent in control databases and 100 healthy subjects originating from the same population. We report a novel variant in the CDON gene associated with PSIS and congenital cranial nerve palsy. The variant revealed autosomal dominant inheritance with incomplete penetrance in concordance with previous studies reporting CDON defects.
Improved and Sustained Graduate Programs Diversity Outcomes: a 10-year Analysis and Summary of the Brown University IMSD Program
Authors: Campbell Andrew G. , Thompson Nancy L. , Duncan Marlina , Harrington Elizabeth O. 
Published: July 2021

AbstractThis report describes the 10-year outcome of implementing practices that support and foster success of underrepresented students in science, technology, engineering, and math (STEM) graduate training at Brown University. The results show sustained improvements in compositional diversity, retention, and degree attainment of supported students relative to their peers. Among the outcomes is an increase in enrolled student diversity from 19 (35 of 179) to 26% (58 of 223) for historically underrepresented minority (URM) students and an increase in Ph.D. degree attainment from 4 (1 of 25) to 14% (6 of 44) for this group. These achievements follow the introduction and coordination of academic and co-curricular practices through the National Institutes of General Medical Sciences–funded Brown University Initiative to Maximize Student Development (IMSD) Program. At the center of these outcomes is the alignment of IMSD practices with recent diversity initiatives launched by the university. The outcomes described result from long-term commitments to building a culture that includes: (1) development of relationships that serve underrepresented students, (2) provision of a personalized education program of support and skills-based learning that supplements discipline-based research and coursework, and (3) investments in processes that build a culture that values and benefits from diversity. These practices may yield similar outcomes and success for students when applied elsewhere.
Validation of the Chinese Version of the Gender Identity/Gender Dysphoria Questionnaire for Adolescents and Adults
Authors: Wang Yuanyuan , Feng Yi , Su Di , Wilson Amanda , Pan Bailin , Liu Ye , Wang Ning , Guo Bin , Han Meng , Zucker Kenneth J. , Chen Runsen 
Published: July 2021

ABSTRACTBackgroundThe number of individuals with potential gender dysphoria (GD) being referred to specialized gender identity clinics or programs is increasing internationally; these cases are initially screened using the Gender Identity/Gender Dysphoria Questionnaire for Adolescents and Adults (GIDYQ-AA).AimThe current study aimed to assess the psychometric properties of the GIDYQ-AA in a sample of adolescents and young adults from China.MethodsA cross-sectional study was conducted in October 2020. Sociodemographic information of the participants was first collected. Participants then completed the GIDYQ-AA, the Generalized Anxiety Disorder-7 scale, the Patient Health Questionnaire-9, and a suicidal ideation assessment. A total of 2,533 participants with a mean age of 19.30 (SD = 1.19) years were recruited. Of the participants, 841 (33.2%) were cis men, 1,589 (62.7%) were cis women, 66 (2.6%) self-identified as transgender, 17 (0.7%) self-identified as non-binary, and 20 (0.8%) self-identified as gender queer.RESULTSThe GIDYQ-AA had high internal consistency with a Cronbach’s alpha = 0.89. Exploratory factor analysis showed that the GIDYQ-AA had a four-factor structure in China. The GIDYQ-AA was significantly correlated with anxiety symptoms (r = –0.32, P &lt; .01), depressive symptoms (r = –0.33, P &lt; .01), and suicidal ideation (r = –0.20, P &lt; .01).Clinical TranslationThe Chinese version of GIDYQ-AA is a useful measurement with high practical value, which could promote the assessment and research of GD across China or among Chinese migrants in other countries.Strengths and LimitationsThis is the first study assessing the psychometric properties of the GIDYQ-AA in Chinese adolescents and young adults. The convergent and divergent validity of the GIDYQ-AA were not examined due to the unavailability of data. Also, the sample did not have an equal distribution of male to males and female to females.CONCLUSIONThe Chinese version of GIDYQ-AA is a useful measure, which could promote both the assessment and research of GD in the Chinese population.
Analysis of bird situation around airports using avian radar
Authors: Chen W.S. , Huang Y.F. , Lu X.F. , Zhang J. 
Published: July 2021

AbstractTo improve the ability of avian radar to process bird information, a statistical analysis method for the bird situation around airport is proposed based on avian radar data. By accumulating a large amount of avian radar data, hotspots of the activity area of bird targets can be determined and taken as a reference point to realise lifecycle management of each bird target from initiation to continuation and finally death. In the process of target tracking, combined with the particle filter method, the probability of several possible events is estimated, leading to completion of the data association and real-time statistics for the number of targets. The simulation results reveal that this method is superior to the traditional logic method regarding the timeliness of multi-target initiation. With the application of the proposed method to avian radar data, the bird population and its basic activity rules can be discovered by fixing the bird habitats around the airport.
The ‘ultimate insurance’ or an ‘irrelevance’ for national security needs? Partisanship, foreign policy attitudes, and the gender gap in British public opinion towards nuclear weapons
Authors: Clements Ben , Thomson Catarina P. 
Published: July 2021

AbstractOnly two European countries – France and the UK, both NATO members – have nuclear weapons, and leading politicians have called for the UK and EU to maintain close military and security links post-Brexit. In the context of the Trident renewal debate and the UK government's recently published integrated defence and security review, this article uses data from the new UK Security Survey to analyse attitudes towards the possession of nuclear weapons among the British public. It assesses three key theorical strands in the wider scholarly literature on public opinion and states’ use of military force: domestic political attitudes, foreign policy predispositions, and the ‘gender gap’. We find that all three theoretical perspectives contribute to the underpinnings of contemporary public opinion towards nuclear weapons. Support for the retention of Britain's nuclear deterrent is associated with being a Conservative Party supporter, favouring Brexit, endorsing superior military power worldwide as an important foreign policy goal, wanting to protect the transatlantic relationship, and with being male. The article makes a distinctive contribution to the growing subfield of research on public opinion and foreign policy, while the findings advance wider empirical understanding of contemporary citizen engagement in a key dimension of security policy.
The unhappy chaperone
Authors: Linse Sara , Thalberg Kyrre , Knowles Tuomas P. J. 
Published: July 2021

AbstractChaperones protect other proteins against misfolding and aggregation, a key requirement for maintaining biological function. Experimental observations of changes in solubility of amyloid proteins in the presence of certain chaperones are discussed here in terms of thermodynamic driving forces. We outline how chaperones can enhance amyloid solubility through the formation of heteromolecular aggregates (co-aggregates) based on the second law of thermodynamics and the flux towards equal chemical potential of each compound in all phases of the system. Higher effective solubility of an amyloid peptide in the presence of chaperone implies that the chemical potential of the peptide is higher in the aggregates formed under these conditions compared to peptide-only aggregates. This must be compensated by a larger reduction in chemical potential of the chaperone in the presence of peptide compared to chaperone alone. The driving force thus relies on the chaperone being very unhappy on its own (high chemical potential), thus gaining more free energy than the amyloid peptide loses upon forming the co-aggregate. The formation of heteromolecular aggregates also involves the kinetic suppression of the formation of homomolecular aggregates. The unhappiness of the chaperone can explain the ability of chaperones to favour an increased population of monomeric client protein even in the absence of external energy input, and with broad client specificity. This perspective opens for a new direction of chaperone research and outlines a set of outstanding questions that aim to provide additional cues for therapeutic development in this area.
Short-term effects of a Mediterranean-style dietary pattern on cognition and mental well-being: a systematic review of clinical trials
Authors: Esgunoglu Latife , Jennings Amy , Connole Elizabeth Sanchia , Murphy Karen Joy , Minihane Anne Marie 
Published: July 2021

AbstractAlthough the long-term effects of a Mediterranean-style dietary pattern (MDP) on cognition and overall mental well-being have been consistently described, the short-term effects of the MDP on cognitive performance, mood and anxiety have not been as widely reviewed. Therefore, the aims of this systematic review were to synthesise the evidence from randomised controlled trials (RCT), to examine whether a MDP can alter cognition and overall mental well-being in the short-term (up to 10 d). This will also be used to identify research gaps and to inform the design of future acute RCT in the area. Ovid Embase, Ovid MEDLINE and Web of Science Core Collection were searched from inception to 8 December 2020. The data were synthesised narratively with no quantitative synthesis. The detailed protocol is available on PROSPERO, with the registration number CRD42021221085. A total of 3002 studies were initially identified. After the deduplication and screening stages, four studies (three articles and one conference proceeding) were eligible to be included. Despite the very limited data obtained, the literature suggests that a MDP can improve cognition and mood in the short-term. Specifically, improvements in attention, alertness and contentment were consistently reported. A MDP appears as a promising strategy to improve short-term cognitive and mental health. A limitation of this review is the small number of studies identified; therefore, future studies are required to confirm these initial novel findings and to provide granularity as to which domains are most responsive and in which population subgroups.
Body size, sex and high philopatry influence the use of agricultural land by Galapagos giant tortoises
Authors: Pike Kyana N. , Blake Stephen , Cabrera Freddy , Gordon Iain J. , Schwarzkopf Lin 
Published: July 2021

AbstractAs agricultural areas expand, interactions between wild animals and farmland are increasing. Understanding the nature of such interactions is vital to inform the management of human–wildlife coexistence. We investigated patterns of space use of two Critically Endangered Galapagos tortoise species,Chelonoidis porteriandChelonoidis donfaustoi, on privately owned and agricultural land (hereafter farms) on Santa Cruz Island, where a human–wildlife conflict is emerging. We used GPS data from 45 tortoises tracked for up to 9 years, and data on farm characteristics, to identify factors that influence tortoise movement and habitat use in the agricultural zone. Sixty-nine per cent of tagged tortoises used the agricultural zone, where they remained for a mean of 150 days before returning to the national park. Large male tortoises were more likely to use farms for longer periods than female and smaller individuals. Tortoises were philopatric (mean overlap of farmland visits = 88.7 ± SE 2.9%), on average visiting four farms and occupying a mean seasonal range of 2.9 ± SE 0.3 ha. We discuss the characteristics of farm use by tortoises, and its implications for tortoise conservation and coexistence with people.
Are policymakers responsive to public demand in climate politics?
Authors: Schaffer Lena Maria , Oehl Bianca , Bernauer Thomas 
Published: July 2021

AbstractNormative theories of democracy agree that public demand should be the main guide in policymaking. But positive theories and related empirical research disagree about the extent to which this holds true in reality. We address this debate with an empirical focus on climate change policy. Specifically, we are interested in whether observable variation in public demand for climate change mitigation can help explain variation in adopted national climate policies. Using our own data to approximate public demand, we estimate the responsiveness of policymakers to changes in public demand in six OECD countries from 1995 to 2010. We find that policymakers are responsive and react in predicted ways to variation in our opinion component of measured public demand, rather than to the mere salience of the climate issue. The effect of issue salience is strongest in combination with our opinion measure as this creates a scope for action. The results underscore the importance and usefulness of our concept and empirical measures for public demand, as well as of our disaggregated analysis of climate policy outputs in this area.
The power-trust cycle in global health: Trust as belonging in relations of dependency
Authors: Anderson Emma-Louise , Considine Laura , Patterson Amy S. 
Published: July 2021

AbstractTrust between actors is vital to delivering positive health outcomes, while relationships of power determine health agendas, whose voices are heard and who benefits from global health initiatives. However, the relationship between trust and power has been neglected in the literatures on both international politics and global health. We examine this relationship through a study of relations between faith based organisations (FBO) and donors in Malawi and Zambia, drawing on 66 key informant interviews with actors central to delivering health care. From these two cases we develop an understanding of ‘trust as belonging’, which we define as the exercise of discretion accompanied by the expression of shared identities. Trust as belonging interacts with power in what we term the ‘power-trust cycle’, in which various forms of power undergird trust, and trust augments these forms of power. The power-trust cycle has a critical bearing on global health outcomes, affecting the space within which both local and international actors jockey to influence the ideologies that underpin global health, and the distribution of crucial resources. We illustrate how the power-trust cycle can work in both positive and negative ways to affect possible cooperation, with significant implications for collective responses to global health challenges.
Freeze tolerance in neotropical frogs: an intrageneric comparison using Pristimantis species of high elevation and medium elevation
Authors: Carvajalino-Fernández Juan Manuel , Bonilla Gomez Maria Argenis , Giraldo-Gutierréz Liliana , Navas Carlos Arturo 
Published: July 2021

AbstractParamos are high-elevation tropical Andean ecosystems above the tree line that display variable temperature and frequent freezing spells. Because a significant anuran community lives in this environment, physiological protection against freezing must characterise individuals in this community. Antifreeze protection has been studied in amphibians from other communities, and it is likely that Paramo anurans rely on the same underlying molecules that convey such protection to Nearctic species. However, given the pervasive presence of freezing spells in the Paramos year-round, the processes of activating protection mechanisms may differ from that of seasonal counterparts. Accordingly, this study investigated cryoprotection strategies in high-elevation tropical frogs, using as a model the terrestrial and nocturnal genus Pristimantis, specifically P. bogotensis, P. elegans and P. nervicus from Paramos, and the warm ecosystem counterparts P. insignitus, P. megalops and P. sanctaemartae. We focused on freeze tolerance and its relationship with glucose accumulation and ice formation. Under field conditions, the highest elevation P. nervicus exhibited higher glucose concentration at dawn compared to noon (1.7 ± 0.6 mmol/L versus 3.5 ± 1.32 mmol/L). Under experimental thermal freeze exposure for 2 hours between −2 and −4 ºC, the glucose concentration of the three Paramo species increased but physiological diversity was evident (P. nervicus 126%; P. bogotensis 100%; and P. elegans 55%). During this test, body ice formation was assessed calorimetrically. The species with the highest body ice formation was P. bogotensis (17% ± 5.37; maximum value: 63%; n = 8), followed by P. nervicus (5% ± 3.27; maximum value: 11%; n = 5) and P. elegans (0.34% ± 0.09; maximum value: 1%; n = 4). The study shows physiological diversity both within a genus and across the amphibian community around the freezing contour. Overall, Paramo species differ in freezing physiology from their low-elevation counterparts. Thus, climate shifts increasing freezing spells may affect the structure of communities in this zone.
Decline and recovery in cell population densities of Heterosigma akashiwo (Raphidophyceae) as a novel bloom driver for the species
Authors: Kok Jerome Wai Kit , Leong Sandric Chee Yew 
Published: July 2021

AbstractThe frequency and intensity of harmful algal bloom (HAB) events have been increasing in many places around the world. Heterosigma akashiwo is a marine raphidophyte species known to cause HABs in many places across tropical and temperate climates. Studies of temperate strains have identified that H. akashiwo blooms are driven by mass activation of cysts which, for this species, can only form at <15°C temperatures. Although these temperatures do not occur in the tropics, there have been no comparative studies for tropical H. akashiwo. This study aimed to investigate whether tropical H. akashiwo can form cysts under warm temperatures, therefore having different responses from temperate strains. Results showed that tropical H. akashiwo were similar with temperate strains and could only form round cyst-like structures at 5°C but not 25°C. We also observed novel response of a decline and recovery in cell densities at 25°C. The decline was interrupted when the cultures were diluted, implying a tendency for H. akashiwo to rapidly spread and accumulate within surrounding waters, thereby facilitating blooms. This behaviour presents unique bloom concerns. Close monitoring of H. akashiwo distribution patterns is needed for better assessment of the bloom threat posed within tropical waters.
Development and preliminary evaluation of EMPOWER for surrogate decision-makers of critically ill patients
Authors: Lichtenthal Wendy G. , Viola Martin , Rogers Madeline , Roberts Kailey E. , Lief Lindsay , Cox Christopher E. , Brewin Chris R. , Xu Jiehui Cici , Maciejewski Paul K. , Pan Cynthia X. , Coats Taylor , Ouyang Daniel J. , Rabin Shayna , Vaughan Susan C. , Breitbart William , Marenberg Marjorie E. , Prigerson Holly G. 
Published: July 2021

AbstractObjectiveThe objectives of this study were to develop and refine EMPOWER (Enhancing and Mobilizing the POtential for Wellness and Resilience), a brief manualized cognitive-behavioral, acceptance-based intervention for surrogate decision-makers of critically ill patients and to evaluate its preliminary feasibility, acceptability, and promise in improving surrogates’ mental health and patient outcomes.MethodPart 1 involved obtaining qualitative stakeholder feedback from 5 bereaved surrogates and 10 critical care and mental health clinicians. Stakeholders were provided with the manual and prompted for feedback on its content, format, and language. Feedback was organized and incorporated into the manual, which was then re-circulated until consensus. In Part 2, surrogates of critically ill patients admitted to an intensive care unit (ICU) reporting moderate anxiety or close attachment were enrolled in an open trial of EMPOWER. Surrogates completed six, 15–20 min modules, totaling 1.5–2 h. Surrogates were administered measures of peritraumatic distress, experiential avoidance, prolonged grief, distress tolerance, anxiety, and depression at pre-intervention, post-intervention, and at 1-month and 3-month follow-up assessments.ResultsPart 1 resulted in changes to the EMPOWER manual, including reducing jargon, improving navigability, making EMPOWER applicable for a range of illness scenarios, rearranging the modules, and adding further instructions and psychoeducation. Part 2 findings suggested that EMPOWER is feasible, with 100% of participants completing all modules. The acceptability of EMPOWER appeared strong, with high ratings of effectiveness and helpfulness (M = 8/10). Results showed immediate post-intervention improvements in anxiety (d = −0.41), peritraumatic distress (d = −0.24), and experiential avoidance (d = −0.23). At the 3-month follow-up assessments, surrogates exhibited improvements in prolonged grief symptoms (d = −0.94), depression (d = −0.23), anxiety (d = −0.29), and experiential avoidance (d = −0.30).Significance of resultsPreliminary data suggest that EMPOWER is feasible, acceptable, and associated with notable improvements in psychological symptoms among surrogates. Future research should examine EMPOWER with a larger sample in a randomized controlled trial.
We Need Accomplices, Not Allies in the Fight for an Equitable Geoscience
Authors: Jones Jabari C. 
Published: July 2021

AbstractThe killing of George Floyd on May 25, 2020 sparked a global movement for black lives that extended into the geosciences. Nearly a year later, some momentum has been sustained, but the appetite for transformative change to generate a more equitable geoscience is lacking. In this article, I detail my struggles to balance science, activism, and anguish as a black geoscientist in Minneapolis over the last year. I suggest that a riskier and deeper involvement in the work of equity and inclusion is necessary to transform our discipline into a diverse, equitable, and inclusive space where all people can thrive.