bluuebunny/crossref_metadata_2025_split huggingface dataset:
Informationen und Berichte
Authors: Kohl Yvonne , Patri Kai Hendrik , Popien Astrid , Kęsicka Karolina , Sommerfeld Beate 
Published: February 2021

„‚Keine Kultur kann auf Dauer von eigener Substanz leben.‘ Günter Grass als Botschafter der Multikulturalität“. Łόdź, 23.-26.10.2008
„Identitätskonstruktionen in fiktionalen und nicht-fiktionalen Texten. Übersetzung und Rezeption“. Translationskolloquium in Poznań, 3.-5.11.2008
Prevención del golpe de ariete mediante el control del tiempo de cierre, al usar válvulas hidráulicas automatizadas
Authors: Guevara-Rodríguez Gregory , Vargas-Obando Adrian , Quesada-Chanto Juan Ignacio 
Published: February 2021

Uno de los grandes retos que enfrentamos, al calibrar sistemas automáticos en riego y acueductos, es que la velocidad de los activadores eléctricos es muy rápida, lo que reduce la velocidad de respuesta de las válvulas en términos de apertura y cierre a algunos cuantos segundos. Estos cierres repentinos en la línea de conducción provocan ondas en el interior de la tubería que producen sobrepresiones que pueden generar daños en nuestro acueducto. El presente trabajo ofrece un enfoque alternativo al control y prevención del golpe de ariete, al analizar la relación entre el tiempo de cierre de una válvula en una conducción con pendiente positiva, el respectivo aumento en la línea piozométrica y cómo se puede regular esto mediante la calibración de la velocidad de cierre en el llenado de la cámara superior de las válvulas hidráulicas. Para la comprobación de los resultados, se muestra el caso de un proyecto de invernaderos, hidropónico, que opera con riegos automáticos, donde el tiempo de apertura y cierre de válvulas fue calibrado mediante el control del llenado de las cámaras de las válvulas.
Biología sintética en la ingenierización de rutas metabólicas de microorganismos para la obtención de compuestos de interés para la industria alimentaria
Authors: Ortuño-Fajardo María Paula , Chacón-Halabi Jose Rodolfo , Flores-Espinoza María Paula , Aguilar-Bravo Roger 
Published: February 2021

La ingeniería de rutas metabólicas, por medio de la biología sintética, se ha convertido en una herramienta de suma importancia para la industria alimentaria, debido a que se busca la optimización de procesos y obtención de compuestos ya existentes. Es posible producir compuestos que son altamente codiciados por el mercado, como enzimas que participan en procesos de fermentación o síntesis de productos de alta demanda, o saborizantes obtenidos de forma natural a partir de microorganismos modificados. Dicha edición genética se ha logrado mediante las técnicas desarrolladas en la rama de la biología sintética a lo largo de los años, como, por ejemplo, el ensamblaje de constructos genéticos y de CRISPR y ARN, mensajeros sintéticos. Estas técnicas son utilizadas para aumentar la productividad de un compuesto de interés en un microorganismo. No obstante, es necesario tomar en cuenta que no todos los microorganismos tienen las herramientas genéticas para realizar las modificaciones post-traduccionales necesarias para otorgar funcionalidad a una enzima o proteína, y que con una ruta metabólica de novo pueden producirse también compuestos e intermediarios tóxicos para el hospedero elegido. Particularmente, en la industria alimentaria es común la elección de microorganismos huéspedes que se consideren seguros para el consumo humano (GRAS) como las bacterias ácido-lácticas (LAB) y, más recientemente, las levaduras del género Saccharomyces.
Editorial à edição temática sobre Educação Maker e Robótica Pedagógica
Authors: Baranauskas Maria Cecília Calani , Valente José Armando 
Published: February 2021

Apresentação
A revista eletrônica Tecnologias, Sociedade e Conhecimento é uma publicação científica do Núcleo de Informática Aplicada à Educação (NIED/UNICAMP), inaugurada há 7 anos, quando o NIED celebrava seus 30 anos de existência. Comprometida com reflexões sobre os avanços da Informática na Educação, a revista visa oferecer à comunidade um espaço de debate – a partir de diferentes perspectivas teóricas, disciplinares e interdisciplinares - sobre o estado atual, os avanços e as tendências futuras de tecnologias relacionadas a contextos de ensino-aprendizagem formais e não formais em nossa sociedade.
A revista é voltada para a divulgação de trabalhos acadêmicos por meio da promoção do acesso livre à informação. Alinhada aos meios contemporâneos de construção, difusão e compartilhamento de conhecimento, a revista é veiculada e gerenciada pelo sistema SEER/OJS[1] instalado nos servidores do NIED. A propriedade Intelectual do conteúdo nela veiculado está oferecido sob Licença Creative Commons (CC-BY)[2].
Esta edição resulta do fluxo de submissões ao número especial na temática Educação Maker e Robótica Pedagógica e inclui artigos científicos, relatos de experiência e resumos estendidos de teses e dissertações. Neste volume, a revista inclui 12 trabalhos assim distribuídos: cinco artigos científicos, quatro relatos de experiência, e três resumos estendidos de teses de doutorado e dissertação de mestrado. As contribuições deste volume foram escritas por autores atuantes na comunidade brasileira de informática na educação, originários de instituições de seis diferentes estados da federação (AL, GO, PR, RJ, RS, SP). Os trabalhos envolvem a temática especial, situada em vários níveis de educação (fundamental...
Descriptive Study of Pediatric Patients with Ileum Stoma at Inpatient Installation of Dr. Soetomo General Hospital Surabaya
Authors: Mikala Farihazqa Hafez , Athiyyah Alpha Fardah , Hariastawa I Gusti Bagus Adria , Ranuh I Gusti Made Reza Gunadi 
Published: February 2021

Introduction: Ileostomy is needed as an important part of the management of several congenital disorders of the intestine. One of the indication of ileostomy in children is short bowel syndrome, which is caused by intestinal atresia such as ileal atresia and intussusception. Ileostomy is a surgery procedure which consists of creating holes on abdominal walls to release stool. The objective of this study was to determine the description of pediatric patients who underwent ileostomy in Dr. Soetomo General Hospital Surabaya. Methods: This was a retrospective descriptive study on medical records in the Central Medical Record Department of Pediatrics and General Surgery Dr. Soetomo General Hospital Surabaya from January 2017 to December 2018. Results: There were 26 pediatric patients who underwent ileostomy in Dr. Soetomo General Hospital Surabaya. Samples from male patients consisted of 57.7%, while female patients consisted of 42.3% with the most common age group was neonates with 57.7%, infants 30.8%, and toddlers 11.5%. There were 30.7% patients with 2.0-2.9 kg body weight, 27% with 3.0-3.9 kg body weight, and 42.3% with more than 4 kg body weight. The outcome showed that repair was needed, or the patient was discharged with periodic follow-up after ileostomy. Conclusion: Ileostomy was performed mostly in neonates with average weight within normal body mass index (BMI) and the highest incidence of pediatric patient with ileum stoma was in pediatric patients.
Los culturemas en la obra de Stephen King: clasificación y procedimientos de traducción
Authors: Vicente-Yagüe Jara Antonio José de , Amor Collado Eva del 
Published: February 2021

Resumen: El objetivo del presente estudio es llevar a cabo un análisis de los culturemas que aparecen en la literatura de Stephen King y de los procedimientos de traducción utilizados por los traductores de sus obras al francés y al español para traducir esos elementos culturales. Debido a la gran cantidad de obras que ha escrito King, nos hemos visto obligados a reducir nuestro corpus de estudio a tres novelas: It, The Shining y Pet Sematary.Para llevar a cabo el análisis del corpus, hemos recopilado, clasificado y estudiado un total de trescientos culturemas: cien de It, cien de The Shining y cien de Pet Sematary. Antes de elaborar dicho análisis, hemos recordado la clasificación de culturemas propuesta por Newmark (1992) y, partiendo de esa base, hemos seleccionado dos categorías específicas para poder darle un enfoque más concreto a nuestro trabajo: «Cultura material» y «Organizaciones, costumbres, actividades, procedimientos y conceptos». De esta manera, dentro de cada obra, hemos seleccionado cincuenta culturemas para cada una de las categorías.Finalmente, hemos realizado un estudio cuantitativo de los procedimientos de traducción que más se han utilizado en francés y en español dentro de cada una de las categorías mencionadas anteriormente. Este análisis nos ha permitido presentar de forma gráfica el porcentaje de uso de cada procedimiento y llegar así a una serie de conclusiones. Abstract: The aim of this paper is to carry out an analysis of the different cultural terms that appear in the works of Stephen King and to study which are the most common translation procedures used when translating cultural terms into two different languages: Spanish and French, since the source language is English. Due to the huge amount of works written by King, we had to select only three novels: It, The Shining and Pet Sematary.In order to carry out the analysis of our corpus, we have compiled, classified and studied a total of three hundred cultural terms: one hundred from It, one hundred from The Shining and one hundred from Pet Sematary. In this regard, it is important to outline that, in the theoretical framework, we explained the classification of cultural terms proposed by Newmark (1992) and, on this basis, we have selected two specific categories in order to give a more concrete approach to our work: “Material culture” and “Organizations, customs, activities, procedures and concepts”. Thus, within each work we have selected fifty cultural terms for each category.Finally, we also wanted to carry out a quantitative study of the translation procedures most commonly used in French and Spanish within each of the categories mentioned in the previous paragraph. This analysis has allowed us to graphically present the percentage of use of each procedure and thus establish a series of conclusions.
U-IMD: The first Unified European registry for Inherited Metabolic Diseases
Authors: Opladen Thomas , Gleich Florian , Kozich Viktor , Scarpa Maurizio , Martinelli Diego , Schaefer Franz , Jeltsch Kathrin , Palacios Natalia Julia , Cazorla Angels Garcia , Vici Carlo Dionisi , Kölker Stefan 
Published: February 2021

Abstract
Background: Following the broad application of new analytical methods, more and more pathophysiological processes in previously unknown diseases have been elucidated. The spectrum of clinical presentation of rare inherited metabolic diseases (IMDs) is broad and ranges from single organ involvement to multisystemic diseases. With the aim of overcoming the limited knowledge about the natural course, current diagnostic and therapeutic approaches, the project has established the first unified patient registry for IMDs that fully meets the requirements of the European Infrastructure for Rare Diseases (ERDRI). Results: In collaboration with the European Reference Network for Rare Hereditary Metabolic Disorders (MetabERN), the Unified European registry for Inherited Metabolic Diseases (U-IMD) was established to collect patient data as an observational, non-interventional natural history study. Following the recommendations of the ERDRI the U-IMD registry uses common data elements to define the IMDs, report the clinical phenotype, describe the biochemical markers and to capture the drug treatment. Until today, more than 1100 IMD patients have been registered.Conclusion: The U-IMD registry is the first observational, non-interventional patient registry that encompasses all known IMDs. Full semantic interoperability for other registries has been achieved, as demonstrated by the use of a minimum common core data set for equivalent description of metabolic patients in U-IMD and in the patient registry of the European Rare Kidney Disease Reference Network (ERKNet). In conclusion, the U-IMD registry will contribute to a better understanding of the long-term course of IMDs and improved patients care by understanding the natural disease course and by enabling an optimization of diagnostic and therapeutic strategies.
mRNP granule proteins Fmrp and Dcp1a differentially regulate mRNP complexes to contribute to control of muscle stem cell quiescence
Authors: Roy Nainita , Sundar Swetha , Pillai Malini , Patell-Socha Farah , Ganesh Sravya , Aloysius Ajoy , Rumman Mohammed , Gala Hardik Paresh , Hughes Simon Meredith , Zammit Peter , Dhawan Jyotsna 
Published: February 2021

Abstract
Background: During skeletal muscle regeneration, satellite stem cells use distinct pathways to repair damaged myofibers or to self-renew by returning to quiescence. Cellular/mitotic quiescence employs mechanisms that promote a poised or primed state, including altered RNA turnover and translational repression. Here, we investigate the role of mRNP granule proteins Fragile X Mental Retardation Protein (Fmrp) and Decapping protein 1a (Dcp1a) in muscle stem cell quiescence and differentiation.Methods: Using isolated single muscle fibers from adult mice, we established differential enrichment of mRNP granule proteins including Fmrp and Dcp1a in muscle stem cells vs. myofibers. We investigated muscle tissue homeostasis in adult Fmr1-/- mice, analyzing myofiber cross-sectional area in vivo and satellite cell proliferation ex vivo. We explored the molecular mechanisms of Dcp1a and Fmrp function in quiescence, proliferation and differentiation in a C2C12 culture model. Here, we used polysome profiling, imaging and RNA/protein expression analysis to establish the abundance and assembly status of mRNP granule proteins in different cellular states, and the phenotype of knockdown cells.Results: Quiescent muscle satellite cells are enriched for puncta containing the translational repressor Fmrp, but not the mRNA decay factor Dcp1a. MuSC isolated from Fmr1-/- mice exhibit defective proliferation and mature myofibers show reduced cross-sectional area, suggesting a role for Fmrp in muscle homeostasis. Expression and organization of Fmrp and Dcp1a varies during primary MuSC activation on myofibers, with Fmrp puncta prominent in quiescence, but Dcp1a puncta appearing during activation/proliferation. This reciprocal expression of Fmrp and Dcp1a puncta is recapitulated in a C2C12 culture model of quiescence and activation: consistent with its role as a translational repressor, Fmrp is enriched in non-translating mRNP complexes abundant in quiescent myoblasts; Dcp1a puncta are lost in quiescence, suggesting stabilized and repressed transcripts. The function of each protein differs during proliferation; whereas Fmrp knockdown led to decreased proliferation and lower cyclin expression, Dcp1a knockdown led to increased cell proliferation and higher cyclin expression. However, knockdown of either Fmrp or Dcp1a led to compromised differentiation. We also observed cross-regulation of decay versus storage mRNP granules; knockdown of Fmrp enhances accumulation of Dcp1a puncta, whereas knockdown of Dcp1a leads to increased Fmrp in puncta.Conclusions: Taken together, our results provide evidence that the balance of mRNA turnover versus utilization is specific for distinct cellular states.
Exposures to 2,4-Dichlorophenoxyacetic acid with or without endotoxin upregulate small cell lung cancer pathway
Authors: Kaur Geetika , Kumar BV Sunil , Singh Baljit , Sethi RS 
Published: February 2021

Abstract
Background: Pesticide residues in food and environment along with airborne contaminants such as endotoxins pose health risk. Although herbicide 2,4-Dichlorophenoxyacetic acid (2,4-D) has been associated with increased risk of lung cancers such as small cell lung cancer (SCLC) among agricultural workers, there are no data on the SCLC signaling pathway upon 2,4-D exposure alone or in combination with endotoxin. Methods: We exposed Swiss albino mice (N=48) orally to high (9.58 mg kg-1) and low (5.12 mg kg-1) dosages of 2,4-D dissolved in corn oil for 90 days followed by E. coli lipopolysaccharide (LPS) or normal saline solution (80µl/animal. Lung samples and broncho-alveolar fluid (BALF) were subjected to Total histological score (THS) and total leucocyte count (TLC) and differential leucocytes count (DLC) analyses, respectively. We used microarray and bioinformatics tools for transcriptomic analyses and differentially expressed genes were analyzed to predict the top canonical pathways followed by validation of selected genes qPCR and immunohistochemistry. Results: Total histological score (THS) along with BALF analyses showed lung inflammation following long term dietary exposure to high or low doses of 2,4-D individually or in combination with LPS. Microarray analysis revealed exposure to high dose of 2,4-D alone or with endotoxin upregulated 2178 and 2142 and downregulated 1965 and 1719 genes, respectively (p<0.05; minimum cut off 1.5 log fold change). The low dose alone or with LPS upregulated 2133 and 2054 and downregulated 1838 and 1625 genes, respectively. Bioinformatics analysis showed SCLC as topmost dysregulated pathway along with differential expression of Itgb1, NF-kB1, p53, Cdk6 and Apaf1. Immunohistological and quantitative real time PCR (qRT-PCR) analyses also supported the transcriptomic data. Conclusions: Taken together, the data show exposures to high and low dose of 2,4-D with/without LPS induced lung inflammation and altered pulmonary transcriptome profile with the involvement of the SCLC pathway. The data from the study provides the insights of the potential damage on lungs caused by 2,4-D and endotoxin interaction and helps to better understand the mechanism of this complex relation.
Functional analysis of (pristine) estuarine marine sediments
Authors: Shah Rohan , Hillyer Katie , Stephenson Sarah , Crosswell Joseph , Karpe Avinash , Paolombo Enzo , Jones Oliver , Gorman Daniel , Bodrossy Levente , de Kamp Jodie van , Bissett Andrew , Whiteley Andrew , Steven Andy , Beale David 
Published: February 2021

Abstract
Traditional environmental monitoring techniques are well suited to resolving acute exposure effects but lack resolution in determining subtle shifts in ecosystem functions resulting from chronic exposure(s). Surveillance with sensitive omics-based technologies could bridge this gap but, to date, most omics-based environmental studies have focused on previously degraded environments, identifying key metabolic differences resulting from anthropogenic perturbations. Here, we apply ‘omic based approaches to pristine environments to establish blueprints of microbial functionality within healthy estuarine sediment communities. We collected surface sediments (n=50) from four pristine estuaries along the Western Cape York Peninsula of Far North Queensland, Australia. Sediment microbiomes were analyzed for 16S rRNA amplicon sequences, central carbon metabolism metabolites and associated secondary metabolites via untargeted metabolic profiling methods. Multivariate statistical analyses indicated heterogeneity amongst the sampled estuaries, however, taxa-function relationships could be established and predicted community metabolism potential. Twenty-four correlated gene-metabolite pathways were identified and used to establish sediment microbial blueprints of carbon metabolism and amino acid biosynthesis. Our results establish a baseline microbial blueprint for the pristine sediment microbiome, one that drives important ecosystem services and to which future ecosurveillance monitoring can be compared.
Epinephrine versus tramazoline to reduce nasal bleeding during nasotracheal intubation. A double-blind randomized trial
Authors: Sato(Boku) Aiji , Sento Yoshiki , Kamimura Yuji , Kako Eisuke , Okuda Masahiro , Tachi Naoko , Okumura Yoko , Hashimoto Mayumi , Hoshijima Hiroshi , Suzuki Fumihito , Sobue Kazuya 
Published: February 2021

Abstract
BACKGROUNDː Nasal bleeding is the most common complication during nasotracheal intubation (NTI). To reduce nasal bleeding, the nasal cavity is treated with vasoconstrictors (epinephrine [E] or tramazoline [T]) prior to NTI. This study aimed to determine whether E or T is more effective and safe for reducing nasal bleeding during NTI.METHODSː This study was preregistered on UMIN-CTR after being approved by the IRB of the School of Dentistry at Aichi Gakuin University. Written consent was received from all the patients. Total 206 patients aged 20–70 years and classified as 1–2 on American Society of Anesthesiologists-physical status were scheduled to undergo general anesthesia with NTI. Patients with a narrowed nasal cavity observed during preoperative CT test (n = 3), patients with hypertension (n = 3), patients undergoing antithrombotic therapy, and patients who did not give consent (n = 3) were excluded from the study. At last, 197 patients were randomly divided into two groups and treated with either E (n = 99; 3 patients were discontinued) or T (n = 98; 2 patient were discontinued). After induction of general anesthesia, each patient’s nasal cavity was treated using either E or T. Next, NTI was performed via the right nostril. Primary outcome was the presence of nasal bleeding. If bleeding was recognized at the posterior pharyngeal wall via nasal cavity during intubation, it was defined as bleeding. Secondary outcomes were the degree of bleeding (classified as none, mild, moderate, or severe), arrhythmia, and hemodynamic (mean atrial pressure and heart rate) changes associated with vasoconstrictors.RESULTSː The presence of bleeding was comparable in both groups (12.5%, E; 14.5%, T; P = 0.63). No significant difference between the groups regarding the degree of bleeding (P = 0.78) was observed, with most patients having no bleeding (n = 84, E; n = 82, T).No severe bleeding and no arrhythmias induced by vasoconstrictor were observed in the two groups.CONCLUSIONSː Nasal treatment with E or T shows no difference in nasal bleeding during NTI. Although no arrhythmia associated with E was observed in this study, it has been reported in literature. Therefore, as frequency and degree of nasal bleeding were comparable, nasal treatment with T could reduce the risk of NTI.Trial RegistrationUMIN-CTR (Registration No. UMIN000037907)