bluuebunny/crossref_metadata_2025_split huggingface dataset:
Activation of cardiac Nmnat/NAD+/SIR2 pathways mediates endurance exercise resistance to lipotoxic cardiomyopathy in aging Drosophila
Authors: Wen Deng-tai , Zheng Lan , Lu Kai , Hou Wen-qi 
Published: September 2021

ABSTRACT
Endurance exercise is an important way to resist and treat high-fat diet (HFD)-induced lipotoxic cardiomyopathy, but the underlying molecular mechanisms are poorly understood. Here, we used Drosophila to identify whether cardiac Nmnat/NAD+/SIR2 pathway activation mediates endurance exercise-induced resistance to lipotoxic cardiomyopathy. The results showed that endurance exercise activated the cardiac Nmnat/NAD+/SIR2/FOXO pathway and the Nmnat/NAD+/SIR2/PGC-1α pathway, including up-regulating cardiac Nmnat, SIR2, FOXO and PGC-1α expression, superoxide dismutase (SOD) activity and NAD+ levels, and it prevented HFD-induced or cardiac Nmnat knockdown-induced cardiac lipid accumulation, malondialdehyde (MDA) content and fibrillation increase, and fractional shortening decrease. Cardiac Nmnat overexpression also activated heart Nmnat/NAD+/SIR2 pathways and resisted HFD-induced cardiac malfunction, but it could not protect against HFD-induced lifespan reduction and locomotor impairment. Exercise improved lifespan and mobility in cardiac Nmnat knockdown flies. Therefore, the current results confirm that cardiac Nmnat/NAD+/SIR2 pathways are important antagonists of HFD-induced lipotoxic cardiomyopathy. Cardiac Nmnat/NAD+/SIR2 pathway activation is an important underlying molecular mechanism by which endurance exercise and cardiac Nmnat overexpression give protection against lipotoxic cardiomyopathy in Drosophila.
Disentangling environmental drivers of circadian metabolism in desert-adapted mice
Authors: Colella Jocelyn P. , Blumstein Danielle M. , MacManes Matthew D. 
Published: September 2021

ABSTRACTMetabolism is a complex phenotype shaped by natural environmental rhythms, as well as behavioral, morphological and physiological adaptations. Metabolism has been historically studied under constant environmental conditions, but new methods of continuous metabolic phenotyping now offer a window into organismal responses to dynamic environments, and enable identification of abiotic controls and the timing of physiological responses relative to environmental change. We used indirect calorimetry to characterize metabolic phenotypes of the desert-adapted cactus mouse (Peromyscus eremicus) in response to variable environmental conditions that mimic their native environment versus those recorded under constant warm and constant cool conditions, with a constant photoperiod and full access to resources. We found significant sexual dimorphism, with males being more prone to dehydration than females. Under circadian environmental variation, most metabolic shifts occurred prior to physical environmental change and the timing was disrupted under both constant treatments. The ratio of CO2 produced to O2 consumed (the respiratory quotient) reached greater than 1.0 only during the light phase under diurnally variable conditions, a pattern that strongly suggests that lipogenesis contributes to the production of energy and endogenous water. Our results are consistent with historical descriptions of circadian torpor in this species (torpid by day, active by night), but reject the hypothesis that torpor is initiated by food restriction or negative water balance.
Heating rates are more strongly influenced by near-infrared than visible reflectance in beetles
Authors: Wang Lu-Yi , Franklin Amanda M. , Black Jay R. , Stuart-Fox Devi 
Published: September 2021

ABSTRACT
Adaptations to control heat transfer through the integument are a key component of temperature regulation in animals. However, there remain significant gaps in our understanding of how different optical and morphological properties of the integument affect heating rates. To address these gaps, we examined the effect of reflectivity in both ultraviolet–visible and near-infrared wavelengths, surface rugosity (roughness), effective area (area subjected to illumination) and cuticle thickness on radiative heat gain in jewel beetles (Buprestidae). We measured heating rate using a solar simulator to mimic natural sunlight, a thermal chamber to control the effects of conduction and convection, and optical filters to isolate different wavelengths. We found that effective area and reflectivity predicted heating rate. The thermal effect of reflectivity was driven by variation in near-infrared rather than ultraviolet–visible reflectivity. By contrast, cuticle thickness and surface rugosity had no detectable effect. Our results provide empirical evidence that near-infrared reflectivity has an important effect on radiative heat gain. Modulating reflectance of near-infrared wavelengths of light may be a more widespread adaptation to control heat gain than previously appreciated.
Under pressure: the relationship between cranial shape and burrowing force in caecilians (Gymnophiona)
Authors: Lowie Aurélien , De Kegel Barbara , Wilkinson Mark , Measey John , O'Reilly James C. , Kley Nathan J. , Gaucher Philippe , Brecko Jonathan , Kleinteich Thomas , Van Hoorebeke Luc , Herrel Anthony , Adriaens Dominique 
Published: September 2021

ABSTRACTCaecilians are elongate, limbless and annulated amphibians that, with the exception of one aquatic family, all have an at least partly fossorial lifestyle. It has been suggested that caecilian evolution resulted in sturdy and compact skulls with fused bones and tight sutures, as an adaptation to their head-first burrowing habits. However, although their cranial osteology is well described, relationships between form and function remain poorly understood. In the present study, we explored the relationship between cranial shape and in vivo burrowing forces. Using micro-computed tomography (µCT) data, we performed 3D geometric morphometrics to explore whether cranial and mandibular shapes reflected patterns that might be associated with maximal push forces. The results highlight important differences in maximal push forces, with the aquatic Typhlonectes producing a lower force for a given size compared with other species. Despite substantial differences in head morphology across species, no relationship between overall skull shape and push force could be detected. Although a strong phylogenetic signal may partly obscure the results, our conclusions confirm previous studies using biomechanical models and suggest that differences in the degree of fossoriality do not appear to be driving the evolution of head shape.
Comparison of 1480 nm and 980 nm-pumped Gallium-Erbium fiber amplifier
Authors: Ibrahim Siti Azlida , Mansoor Amilia , Tuan Mohd Marzuki Tuan Ainin Sofea , Omar Nasr Y. M. , Abdul Rashid Hairul Azhar 
Published: September 2021

Background: One way to reduce the length of the gain medium in Erbium-Doped Fiber Amplifier (EDFA) is by doping the fiber core with a high concentration of Erbium. However, this method caused ion clustering effects, which limits the EDFA’s efficiency. In this research, the use of Gallium as a new co-dopant in erbium-doped silica fiber is explored. Methods: The new fiber, namely Gallium co-doped Erbium fiber (Ga-EDF), is used as a gain medium in an optical fiber amplifier setup. A 2-meter length of the Ga-EDF fiber was used in a single pass configuration with a forward pumping scheme at 150 mW pump power. The Ga-EDF amplifier's gain and noise figure while pumping at 980 nm and 1480 nm were compared. The amplifier's performance was evaluated as the input signal power varied between -30 dBm to 3 dBm, over the wavelength range of 1520 nm to 1580 nm. Results: The 980 nm-pumped Ga-EDF amplifier achieved the maximum small-signal gain of 22.45 dB and the corresponding noise figure of 5.71 dB at the input signal wavelength of 1535 nm. Meanwhile, the 1480 nm-pumped Ga-EDF amplifier attained the maximum small-signal gain of 20.83 dB and the corresponding noise figure of 5.09 dB at the input signal wavelength of 1550 nm. At the input signal power below -20 dBm and the wavelength range 1520 nm to 1547 nm, the Ga-EDF performs better when pumped at 980 nm. Their performance is comparable at the input signal wavelength range between 1547 nm to 1580 nm. At the input signal power above -20 dBm, the 1480 nm-pumped Ga-EDF outperformed the 980 nm-pumped amplifier. Conclusions: The overall performance indicates that the gain saturation point of the 1480 nm-pumped amplifier is higher than the 980 nm-pumped.
Orchestration of autonomous trusted third-party banking
Authors: Muthaiyah Saravanan , Anbananthen Kalaiarasi Sonai Muthu , Phuong Lan Nguyen Thi 
Published: September 2021

Background Digital transformation is changing the structure and landscape of future banking needs with much emphasis on value creation. Autonomous banking solutions must incorporate on-the-fly processing for risky transactions to create this value. In an autonomous environment, access control with role and trust delegation has been said to be highly relevant. The aim of this research is to provide an end to end working solution that will enable autonomous transaction and task processing for banking. Method We illustrate the use case for task delegation with the aid of risk graphs, risk bands and finite state machines. This paper also highlights a step by step task delegation process using a risk ordering relation methodology that can be embedded into smart contracts. Results Task delegation with risk ordering relation is illustrated with six process owners that share immutable ledgers. Task delegation properties using Multi Agent Systems (MAS) is used to eliminate barriers for autonomous transaction processing. Secondly, the application of risk graph and risk ordering relation with reference to delegation of tasks is a novel approach that is nonexistent in RBAC. Conclusion The novelty of this study is the logic for task delegation and task policies for autonomous execution on autonomous banking platforms akin to the idea of federated ID (Liberty Alliance).
Team Relationships and Performance: Evidence from Healthcare Referral Networks
Authors: Agha Leila , Ericson Keith Marzilli , Geissler Kimberley H. , Rebitzer James B. 
Published: September 2021

We examine the teams that emerge when a primary care physician (PCP) refers patients to specialists. When PCPs concentrate their specialist referrals—for instance, by sending their cardiology patients to fewer distinct cardiologists—repeat interactions between PCPs and specialists are encouraged. Repeated interactions provide more opportunities and incentives to develop productive team relationships. Using data from the Massachusetts All Payer Claims Database, we construct a new measure of PCP team referral concentration and document that it varies widely across PCPs, even among PCPs in the same organization. Chronically ill patients treated by PCPs with a one standard deviation higher team referral concentration have 4% lower healthcare utilization on average, with no discernible reduction in quality. We corroborate this finding using a national sample of Medicare claims and show that it holds under various identification strategies that account for observed and unobserved patient and physician characteristics. The results suggest that repeated PCP-specialist interactions improve team performance. This paper was accepted by Carri Chan, healthcare management.
Broadband laser chaos generation using a quantum cascade laser with optical feedback
Authors: Chen Chaojie , Jia Zhiwei , Lv Yuxiang , Li Pu , Xu Bingjie , Wang Yuncai 
Published: September 2021

We propose a method to generate broadband laser chaos using a quantum cascade laser (QCL). Through numerical simulation, we give the evidence that the QCL with optical feedback can route to chaos through the quasi-periodic path. Furthermore, we investigate the influence of the feedback intensity and the bias current on the chaos bandwidth. Final results demonstrate that the chaos bandwidth can headily reach 43.1 GHz due to the lack of relaxation oscillation phenomena in QCLs.
Demonstration of an external cavity semiconductor mode-locked laser
Authors: Yuan Meiyan , Wang Weiqiang , Wang Xinyu , Wang Yang , Yang Qinghua , Cheng Dong , Liu Yang , Huang Long , Zhang Mingran , Liang Bo , Zhao Wei , Zhang Wenfu 
Published: September 2021

Electrically pumped semiconductor mode-locked lasers (SMLs) are promising in a wide range of applications due to compact size, high energy efficiency, and low cost. However, the long gain interaction length increases the spontaneous emission noise. In this Letter, an external cavity structure is adopted to improve the SML noise performance, as well as the flexibility to adjust the repetition rate. Two external cavity SMLs with repetition rates of 255 MHz and 10 GHz are demonstrated. For the 10 GHz SML, the signal-noise-ratio and radio frequency linewidth of the fundamental frequency reach 81.1 dB and 40 Hz, respectively. The high performance makes the laser a promising light source for microwave and communication applications.
Wide angle holographic video projection display
Authors: Chlipała Maksymilian , Kozacki Tomasz , Yeom Han-Ju , Martinez-Carranza Juan , Kukołowicz Rafał , Kim Jinwoong , Yang Jong-Heon , Choi Ji Hun , Pi Jae-Eun , Hwang Chi-Sun 
Published: September 2021

Holographic projection displays provide high diffraction efficiency. However, they have a limited projection angle. This work proposes a holographic projection display with a wide angle, which gives an image of size

306

m
m

×

161

m
m

at 700 mm and reduced speckle noise. The solution uses single Fourier lens imaging with a frequency filter and hologram generation utilizing complex coding and nonparaxial diffraction. The experiment was performed with a 4K phase-only spatial light modulator (SLM) to prove the high efficiency of the developed numerical tools. Optical reconstruction shows high resolution and high image quality achieved from a single frame. Hence, displaying video at a full frame rate of the SLM is possible.
Hybrid-integrated diode laser in the visible spectral range
Authors: Franken C. A. A. , van Rees A. , Winkler L. V. , Fan Y. , Geskus D. , Dekker R. , Geuzebroek D. H. , Fallnich C. , van der Slot P. J. M. , Boller K.-J. 
Published: September 2021

Generating visible light with wide tunability and high coherence based
on photonic integrated circuits is of high interest for applications
in biophotonics, precision metrology, and quantum technology. Here we
present, to our knowledge, the first demonstration of a
hybrid-integrated diode laser in the visible spectral range. Using an
AlGaInP optical amplifier coupled to a low-loss

S

i

3

N

4

feedback circuit based on microring
resonators, we obtain a spectral coverage of 10.8 nm around 684.4 nm
wavelength with up to 4.8 mW output power. The measured intrinsic
linewidth is

2.3

±

0.2

k
H
z

.
Miniature 120-beam coherent combiner with 3D-printed optics for multicore fiber-based endoscopy
Authors: Sivankutty Siddharth , Bertoncini Andrea , Tsvirkun Victor , Gajendra Kumar Naveen , Brévalle Gaelle , Bouwmans Géraud , Andresen Esben Ravn , Liberale Carlo , Rigneault Hervé 
Published: September 2021

In this Letter, we report a high-efficiency, miniaturized, ultra-fast coherent beam, combined with 3D-printed micro-optics directly on the tip of a multicore fiber bundle. The highly compact device footprint (180 µm in diameter) facilitates its incorporation into a minimally invasive ultra-thin nonlinear endoscope to perform two-photon imaging.
Tiny velocity measurement using rotating petal-like mode of orbital angular momentum
Authors: Zhang Zijing , Cen Longzhu , Wang Feng , Zhao Yuan 
Published: September 2021

A novel, to the best of our knowledge, tiny velocity measurement system is proposed and demonstrated. This proposed system employs an interference structure in which the reference and measurement paths are filled by two light beams carrying opposite-sign orbital angular momentum (OAM), respectively. The tiny velocity to be measured in the measurement path causes the change of the light path and results in a time-varying phase shift between the reference and measurement paths. This time-varying phase shift leads to the rotation of the petal-like light spot obtained by the interference between two paths. The rotating angular velocity of the petal-like light spot is proportional to the time-varying phase shift caused by the tiny velocity, and it is measured by a chopper and a single-point detector instead of array detectors. This proposed system has a simple structure and achieves a high-accuracy tiny velocity measurement with a measurement error rate that is less than 10 nm/s.
BEEM-Static: Accurate inference of ecological interactions from cross-sectional microbiome data
Authors: Li Chenhao , Av-Shalom Tamar V. , Tan Jun Wei Gerald , Kwah Junmei Samantha , Chng Kern Rei , Nagarajan Niranjan 
Published: September 2021

The structure and function of diverse microbial communities is underpinned by ecological interactions that remain uncharacterized. With rapid adoption of next-generation sequencing for studying microbiomes, data-driven inference of microbial interactions based on abundance correlations is widely used, but with the drawback that ecological interpretations may not be possible. Leveraging cross-sectional microbiome datasets for unravelling ecological structure in a scalable manner thus remains an open problem. We present an expectation-maximization algorithm (BEEM-Static) that can be applied to cross-sectional datasets to infer interaction networks based on an ecological model (generalized Lotka-Volterra). The method exhibits robustness to violations in model assumptions by using statistical filters to identify and remove corresponding samples. Benchmarking against 10 state-of-the-art correlation based methods showed that BEEM-Static can infer presence and directionality of ecological interactions even with relative abundance data (AUC-ROC>0.85), a task that other methods struggle with (AUC-ROC<0.63). In addition, BEEM-Static can tolerate a high fraction of samples (up to 40%) being not at steady state or coming from an alternate model. Applying BEEM-Static to a large public dataset of human gut microbiomes (n = 4,617) identified multiple stable equilibria that better reflect ecological enterotypes with distinct carrying capacities and interactions for key species.

Conclusion
BEEM-Static provides new opportunities for mining ecologically interpretable interactions and systems insights from the growing corpus of microbiome data.
Can empathy be taught? A cross-sectional survey assessing training to deliver the diagnosis of end stage renal disease
Authors: Doreille Alice , Vilaine Eve , Belenfant Xavier , Tabbi Wided , Massy Ziad , Corruble Emmanuelle , Basse Odile , Luque Yosu , Rondeau Eric , Benhamou Dan , François Helene 
Published: September 2021

Background
Receiving the diagnosis of kidney failure has a major impact on patients. Yet, the way in which this diagnosis should be delivered is not formally taught within our medical curriculum. To fill this gap we set up a training course of kidney failure diagnosis delivery for nephrology trainees since 2016. This study assessed the effectiveness of this educational intervention.

Methods
The primary outcome was change in the empathy score immediately after the training session and several months afterward, based on the Jefferson Scale of Physician Empathy (JSPE). Self-reported change in clinical practice was also evaluated. As control groups, we assessed empathy levels in untrained nephrology trainees (n = 26) and senior nephrologists (n = 71). Later on (>6 months) we evaluated participants’ perception of changes in their clinical practice due to the training.

Results
Six training sessions permitted to train 46 trainees. Most respondents (76%) considered the training to have a durable effect on their clinical practice. Average empathy scores were not significantly different in pre-trained trainees (average JSPE: 103.7 ± 11.4), untrained trainees (102.8 ± 16.4; P = 0.81) and senior nephrologists (107.2 ± 13.6; P = 0.15). Participants’ empathy score significantly improved after the training session (112.8 ± 13.9; P = 0.003). This improvement was sustained several months afterwards (average JSPE 110.5 ± 10.8; P = 0.04).

Conclusion
A single 4-hour training session can have long lasting impact on empathy and clinical practice of participants. Willingness to listen, empathy and kindness are thought to be innate and instinctive skills, but they can be acquired and should be taught.
COVID-19 vaccines and mental distress
Authors: Perez-Arce Francisco , Angrisani Marco , Bennett Daniel , Darling Jill , Kapteyn Arie , Thomas Kyla 
Published: September 2021

Background
The COVID-19 pandemic brought about large increases in mental distress. The uptake of COVID-19 vaccines is expected to significantly reduce health risks, improve economic and social outcomes, with potential benefits to mental health.

Purpose
To examine short-term changes in mental distress following the receipt of the first dose of the COVID-19 vaccine.

Methods
Participants included 8,003 adults from the address-based sampled, nationally representative Understanding America Study (UAS), surveyed at regular intervals between March 10, 2020, and March 31, 2021 who completed at least two waves of the survey. Respondents answered questions about COVID-19 vaccine status and self-reported mental distress as measured with the four-item Patient Health Questionnaire (PHQ-4). Fixed-effects regression models were used to identify the change in PHQ-4 scores and categorical indicators of mental distress resulting from the application of the first dose of the COVID-19 vaccine.

Results
People who were vaccinated between December 2020 and March 2021 reported decreased mental distress levels in the surveys conducted after receiving the first dose. The fixed-effects estimates show an average effect of receiving the vaccine equivalent to 4% of the standard deviation of PHQ-4 scores (p-value<0.01), a reduction in 1 percentage point (4% reduction from the baseline level) in the probability of being at least mildly depressed, and of 0.7 percentage points (15% reduction from the baseline level) in the probability of being severely depressed (p-value = 0.06).

Conclusions
Getting the first dose of COVID-19 resulted in significant improvements in mental health, beyond improvements already achieved since mental distress peaked in the spring of 2020.