bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multilocalitŕ: un concetto emergente fra mobilitŕ e migrazione
Authors: Nadler Robert 
Published: June 2021

Da tempo il tema della mobilitŕ sociale e spaziale interessa discipline come la sociologia, la geografia e l'economia. I processi migratori, dall'altro, sono diventati un oggetto specifico della ricerca scientifica. Tuttavia entrambi si sono sviluppati all'interno delle societŕ industriali moderne e appare lecito dubitare del fatto che essi possano ancora rappresentare in modo adeguato la condizione di individui e di gruppi sociali post-moderni che devono organizzare la propria vita in contesti socio-spaziali altamente flessibili. L'Ufficio Federale per l'Edilizia e la Progettazione Regionale tedesco () ha recentemente dedicato un numero speciale della rivista "Informazioni sullo Sviluppo Spaziale" () al tema della multilocalitŕ. Il termine sta assumendo sempre piů importanza nel dibattito internazionale al fine di descrivere alcuni tratti specifici della vita quotidiana postmoderna. In questo saggio l'autore ripercorre i passaggi salienti del dibattito sul tema in corso nell'ambiente scientifico di lingua tedesca. In un primo momento, descrivendo il significato attribuito al concetto di multilocalitŕ e agli elementi che lo differenziano da quelli di mobilitŕ e di migrazione. In seguito, mostrandone i campi di applicazione di maggiore interesse per la ricerca scientifica.
Pratiche etnografiche nel mondo urbano. Il dibattito francese
Authors: Bergamaschi Maurizio , Casterignanň Marco 
Published: June 2021

Gli autori intendono presentare al lettore italiano alcune piste di ricerca che caratterizzano oggi il panorama dell'etnografia urbana in Francia. Dai contributi presentati si evince che l'approccio etnografico consente di "andare oltre" la conoscenzache si ha dei fenomeni urbani. Gli autori ritengono che in questo sia possibile far emergere un'"altra cittŕ" che tuttavia, per poter essere scoperta, necessita dell'epistemologia e del metodo che caratterizzano il lavoro sul campo di tipo etnografico.
Riorentare lo sguardo, ricercare un'intimitŕ
Authors: de Biase Alessia 
Published: June 2021

L'autrice si domanda come concepire un territorio complesso e gravato da un immaginario soffocante che influenza enormemente la maniera in cui lo si osserva. L'autrice si č posta questa domanda quando ha aperto un corso su uno deifrancesi piů stigmatizzati, idella Courneuve. Come accompagnare e costruire una riflessione assieme agli studenti e agli abitanti senza ricadere nell'utopia della tabula rasa o invocare il ruolo demiurgico dell'architetto? L'articolo si propone di descrivere il processo attraverso il quale si č cercato di spingere gli studenti a riorientare lo sguardo, ad introdurre degli scarti nelle loro interpretazioni, e infine, attraverso la produzione di falsi documentari, ad assumere una posizione progettuale nell'elaborazione di un gioco di partecipazione.
DETERMINATION OF TRACE ELEMENTS IN SOME BRANDS OF GREEN TEA USING WET DIGESTION, INFUSION AND DRY ASHING METHODS
Authors: Imrana Ibrahim , Aminu Salisu , Bilal Umar , Mujitafa Bello Sada 
Published: June 2021

The concentrations of trace elements (Cu, Zn, Fe, Mn and Ni) in some commercially available brands of green tea sold within Katsina metropolis coded (SGT, HGT, LGT, AGT and GGT) were determined using wet acid digestion, water infusion, and Dry Ashing methods by Atomic Absorption Spectroscopy (AAS). Among the trace elements analyzed Nickel and Manganese recorded the highest value ranged 1.0 – 3.5 mg kg-1 and1.0 – 5.5 mg kg-1 in dry ashing and wet digestion respectively. Fortunately, almost all the elements analyzed were within the standard permissible limit of WHO. The content of trace elements was found highest in the Dry Ashing method and lowest values recorded in tea infusion. The contributory factors responsible for the differences found in tea samples could be from a varying concentration of metals in the soil, conditions of cultivation and preparations, and these vary between both countries of origin and for the type of tea. Further work is recommended on these brands to study other important parameters
Personalized Antiplatelet Therapy Based on CYP2C19 Genotypes in Chinese ACS Patients Undergoing PCI: A Randomized Controlled Trial
Authors: Shi Xiujin , Zhang Yunnan , Zhang Yi , Zhang Ru , Lin Baidi , Han Jialun , Li Wenzheng , Fang Zhenwei , Yan Jialin , Wang Yifan , Zheng Ze , Lv Yuan , Lin Yang 
Published: June 2021

Background: The clinical benefits of cytochrome P450 (CYP) 2C19 genotype-guided antiplatelet therapy in Asians remain unclear. In this study, we aimed to investigate the clinical outcomes of pharmacogenomic antiplatelet therapy in Chinese patients.Methods: Patients with acute coronary syndrome planning to undergo percutaneous coronary intervention were eligible for this study and were randomly divided into a genotype-guided treatment (GT) group and routine treatment (RT) group, with a ratio of 2:1. Patients in the GT group underwent CYP2C19 genotyping (*2 and *3 alleles), and the results were considered in selecting P2Y12 receptor inhibitors. Patients in the RT group were treated with P2Y12 receptor inhibitors according to their clinical characteristics. The primary endpoint was a composite of major adverse cardiovascular or cerebrovascular events (MACCE). The secondary endpoint was significant bleeding events.Results: Finally, 301 patients were enrolled; 75.1% were men and the mean age was 59.7 ± 9.8 years. In total, 281 patients completed the follow-up procedure. The primary endpoint occurred in 16 patients, 6 patients in the GT group and 10 in the RT group. The GT group showed lower MACCE rates than the RT group (6/189 vs. 10/92, 3.2 vs. 10.9%, hazard ratio: 0.281, 95% confidence interval: 0.102–0.773, P = 0.009). There was no statistically difference in significant bleeding events between the GT and RT groups (4.2 vs. 3.3%, hazard ratio: 1.315, 95% confidence interval: 0.349–4.956, P = 0.685).Conclusion: Personalized antiplatelet therapy that is based on CYP2C19 genotypes could decrease MACCE within a 12-month period in Chinese patients with acute coronary syndrome undergoing percutaneous coronary intervention.Clinical Trial Registration:http://www.chictr.org.cn, identifier: ChiCTR2000034352.
Exploiting Thermochronology to Quantify Exhumation Histories and Patterns of Uplift Along the Margins of Tibet
Authors: Furlong Kevin P. , Kirby Eric , Creason C. Gabriel , Kamp Peter J. J. , Xu Ganqing , Danišík Martin , Shi Xuhua , Hodges Kip V. 
Published: June 2021

The utilization of thermal-chronological data to constrain mountain building processes exploits the links among rock uplift, exhumation, and cooling during orogenesis. Conceptually, periods of rapid uplift and associated denudation will lead to cooling of rocks as they approach Earth’s surface. The linkage between uplift and exhumation can be complex, but in practice exhumation is often assumed to directly track uplift. The reconstruction of temperature-time histories via thermochronologic systems provides a proxy method to relate the cooling of rock as it is exhumed toward the surface to orogenesis. For the rapid exhumation rates that can occur in active orogenic systems the thermal history will be complex as a result of heat advection, rates of propagation of thermal perturbations, and other processes that affect the cooling behavior. These effects become amplified as exhumation rates increase, and in regions experiencing exhumation rates greater than ∼0.2–0.3 mm/yr (0.2–0.3 km/Ma) simple assumptions of cooling through a constant geotherm will bias the subsequent interpretation. Here we explore, through a suite of generalized models, the impact of exhumation rate and duration on the resulting thermal history and apparent age results. We then apply lessons from these simple exhumation systems to data sets from the high-relief ranges along the eastern margin of the Tibetan Plateau to determine exhumation histories constrained by those data. The resulting exhumation histories provide constraints on the onset of Cenozoic exhumation, the subsequent pace of exhumation, and on the tectonic history of one of the major fault systems in the central Longmen Shan.
Covid-19 and Growth Hormone/Insulin-Like Growth Factor 1: Study in Critically and Non-Critically Ill Patients
Authors: Ilias Ioannis , Diamantopoulos Aristidis , Botoula Efthymia , Athanasiou Nikolaos , Zacharis Alexandros , Tsipilis Stamatios , Jahaj Edison , Vassiliou Alice G. , Vassiliadi Dimitra A. , Kotanidou Anastasia , Tsagarakis Stylianos , Dimopoulou Ioanna 
Published: June 2021

ObjectiveWe aimed to measure insulin-like growth factor 1 (IGF1) and growth hormone (GH) in critically and non-critically ill patients with Covid-19 and assess them vis-a-vis clinical and laboratory parameters and prognostic tools.Subjects and MethodsWe included patients who were admitted to the wards or the ICU of the largest Covid-19 referral hospital in Greece; patients with non-Covid-19 pneumonia served as controls. Apart from the routine laboratory work-up for Covid-19 we measured GH and IGF1 (and calculated normalized IGF-1 values as standard deviation scores; SDS), after blood sampling upon admission to the wards or the ICU.ResultsWe studied 209 critically and non-critically ill patients with Covid-19 and 39 control patients. Patients with Covid-19 who were ICU non-survivors were older and presented with a worse hematological/biochemical profile (including white blood cell count, troponin, glucose, aminotransferases and lactate dehydrogenase) compared to ICU survivors or Covid-19 survivors in the wards. Overall, IGF-1 SDS was higher in Covid-19 survivors compared to non-survivors (-0.96 ± 1.89 vs -2.05 ± 2.48, respectively, p=0.030). No significant differences were noted in GH between the groups. Nevertheless, in critically ill patients with Covid-19, the prognostic value of IGF-1 (raw data), IGF-1 (SDS) and GH for survival/non-survival was on a par with that of APACHE II and SOFA (with a marginal difference between GH and SOFA).ConclusionIn conclusion, our findings suggest that there might be an association between low IGF1 (and possibly GH) and poor outcome in patients with Covid-19.
Changes in T Lymphocyte Subsets in Different Tumors Before and After Radiotherapy: A Meta-analysis
Authors: Wang Qin , Li Shangbiao , Qiao Simiao , Zheng Zhihao , Duan Xiaotong , Zhu Xiaoxia 
Published: June 2021

PurposeRadiation therapy (RT) induces an immune response, but the relationship of this response with tumor type is not fully understood. This meta-analysis further elucidated this relationship by analyzing the changes in T lymphocyte subsets in different tumors before and after radiotherapy.MethodsWe searched English-language electronic databases including PubMed, EMBASE, and the Cochrane Library to collect studies on the changes in peripheral blood CD3+ T lymphocytes, CD4+ T lymphocytes, and CD8+ T lymphocytes before and after radiotherapy in tumor patients from January 2015 to April 2021. The quality of the included literature was evaluated using the NOS scale provided by the Cochrane Collaboration, and statistical software RevMan 5.4 was used to analyze the included literature. P&lt;0.05 was considered to indicate statistical significance.ResultsA total of 19 studies in 16 articles involving 877 tumor patients were included. All data were collected within 1 month before or after radiotherapy. Meta-analysis showed that numbers of CD3+ T lymphocytes (SMD: -0.40; 95% CI [-0.75, -0.04]; p = 0.03) and CD4+ T lymphocytes (SMD: -0.43; 95% CI: [-0.85, -0.02]; p = 0.04) were significantly reduced after radiotherapy compared with before treatment, but there was no statistically significant difference for CD8+ T lymphocytes (SMD: 0.33; 95% CI: [-0.88, 0.74]; p = 0.12). Subgroup analysis showed that peripheral blood T lymphocytes decreased in head and neck cancer. However, in prostate cancer and breast cancer, there was no significant change in peripheral blood. 1 month after radiotherapy, it has a potential proliferation and activation effect on lymphocytes in esophageal cancer and lung cancer. The results showed that CD8+T lymphocytes increased in peripheral blood after SBRT. Radiotherapy alone reduced CD3+ T lymphocyte numbers.ConclusionsWithin 1 month of radiotherapy, patients have obvious immunological changes, which can cause apoptosis and reduction of T lymphocytes, and affect the balance of peripheral blood immune cells. The degree of immune response induced by radiotherapy differed between tumor types.
HTR2B and SLC5A3 Are Specific Markers in Age-Related Osteoarthritis and Involved in Apoptosis and Inflammation of Osteoarthritis Synovial Cells
Authors: Lu Xin , Fan Yu , Li Mingxia , Chang Xiao , Qian Jun 
Published: June 2021

Objective: Osteoarthritis (OA) is a heterogeneous age-related disease, which is badly difficult to cure due to its complex regulatory networks of pathogenesis. This study explored OA-specific genes in synovial tissues and validated their roles on apoptosis and inflammation of OA synovial cells.Methods: Weighted correlation network analysis (WGCNA) was employed to explore OA-related co-expression modules in the GSE55235 and GSE55457 datasets. Then, this study screened OA-specific genes. After validation of these genes in the GSE12021 and GSE32317 datasets, HTR2B and SLC5A3 were obtained. Their expression was detected in human OA and healthy synovial tissues by RT-qPCR and western blot. OA rat models were constructed by anterior cruciate ligament transection (ACLT) operation. In OA synovial cells, HTR2B and SLC5A3 proteins were examined via western blot. After transfection with sh-HTR2B or sh-SLC5A3, apoptosis and inflammation of OA synovial cells were investigated by flow cytometry and western blot.Results: A total of 17 OA-specific DEGs were identified, which were significantly enriched in inflammation pathways. Among them, HTR2B and SLC5A3 were highly expressed in end-than early-stage OA. Their up-regulation was validated in human OA synovial tissues and ACLT-induced OA synovial cells. Knockdown of HTR2B and SLC5A3 restrained apoptosis and increased TGF-β and IL-4 expression as well as reduced TNF-α and IL-1β expression in OA synovial cells.Conclusion: Collectively, this study identified two OA-specific markers HTR2B and SLC5A3 and their knockdown ameliorated apoptosis and inflammation of OA synovial cells.
Clinical Characteristics and Prognosis of Renal Cell Carcinoma With Spinal Bone Metastases
Authors: Zhai Jianpo , Liu Ning , Wang Hai , Huang Guanglin , Man Libo 
Published: June 2021

BackgroundThe prognosis of renal cell carcinoma (RCC) with spinal bone metastasis (sBM) varies greatly. In this study, we aimed to define the clinical characteristics and prognostic factors of RCC with spinal bone metastasis (sBM) in our center.MethodsThe clinical and medical records of RCC patients with sBMs were collected. The gender, age, time of BM, the extent of BM, the number of BMs, the presence or absence of visceral metastasis, and the pathological type of BM were investigated. All patients were followed up regularly. Overall survival (OS) was calculated from the date of BMs diagnosis to death or last follow-up using Kaplan-Meier method and modelled with Cox regression analysis.ResultsForty-three RCC patients with sBM were collected. sBM was found synchronously in 30 patients (70%) and metachronously in 13 patients (30%). The median survival time was 30 months in 13 patients (30%) with solitary sBM and 19 months in 30 patients (70%) with multiple sBMs (P = 0.002). Visceral metastasis occurred in 12 patients (28%) with the median survival time of 17 months, while the other 31 patients (72%) had no visceral metastasis with the median survival time of 29 months (P&lt;0.001). En-block resection was done in 10 patients with median survival time of 40.1 months. Non-en-block resection were done in 33 patients with median survival time of 19.7 months (P&lt;0.001). Multivariate COX regression analysis showed that MSKCC score, number of BM, visceral metastasis, and en-block resection are the independent prognosis factors of RCC patients with sBM.ConclusionsMSKCC risk stratification, number of sBM, visceral metastasis and en-block resection are significant prognostic factors for OS in RCC patients with spinal BM. Therefore, for selected patients who has solitary spinal BM with no visceral metastasis, en-block resection of spinal BM can potentially prolong survival and is the treatment of choice.
The Change of Public Individual Prevention Practice and Psychological Effect From the Early Outbreak Stage to the Controlled Stage of COVID-19 in China in 2020: Two Cross-Sectional Studies
Authors: Han Bingfeng , Liu Hanyu , Zhao Tianshuo , Liu Bei , Zheng Hui , Wan Yongmei , Cui Fuqiang 
Published: June 2021

BackgroundCOVID-19 broke out in China and spread rapidly in January and February 2020. Following the prevention and control measures of the Chinese government, the outbreak was gradually brought under control after March. The changes in people’s attention to the epidemic, individual prevention practice and psychological effect from the early outbreak stage to the under controlled stage need to be evaluated.MethodsTwo cross-sectional, population-based online surveys were conducted from January 28 to February 1, 2020 and from February1 to March 18, 2020. Socio-demographic information and individual protective practice were collected and the State-Trait Anxiety Inventory (STAI) was used for measuring anxiety. The range of STAI score was 5–25, and the higher the score, the more anxious it was. The respondents of the two surveys were matched on a one-to-one basis according to their province, gender, age, education, and marriage. Wilcoxon signed ranks test and Mann-Whitney U test were used to compare STAI score changes in two stages and in different demographic characteristics.ResultsWe included 9,764 individuals in the first survey and 1,669 in the second survey, covering 30 provincial administrative regions in Mainland China. COVID-19 has affected almost every aspect of people’s normal life, especially lifestyle. The proportion of people who paid attention to it every day had dropped from 97.6 to 88.9%. We identified that vast majority people wore masks when they went out. The proportion has declined from 96.5 to 92.4% for hand hygiene and from 98.4 to 95.3% for not attending parties. People’s anxiety (STAI score) across the country has decreased from a median of 19 in the early outbreak stage to a median of 12, including people with all demographic characteristics, but some have increased in 16 provinces.ConclusionPeople’s attention to information about the epidemic has declined slightly, but a high proportion of people maintained good practices such as wearing masks, hand hygiene, and not attending parties. People’s anxiety had generally declined from the early outbreak stage to the under controlled stage, but it was still at a high level.
Cross-Sectional Associations Between Lifetime Use of Psychedelic Drugs and Psychometric Measures During the COVID-19 Confinement: A Transcultural Study
Authors: Révész Dóra , Ona Genís , Rossi Giordano N. , Rocha Juliana M. , dos Santos Rafael G. , Hallak Jaime E. C. , Alcázar-Córcoles Miguel Á. , Bouso José C. 
Published: June 2021

Background: One of the main public health strategies adopted at the beginning of the COVID-19 pandemic consisted of implementing strict lockdowns to stop the transmission of the virus. Despite being an effective measure, the confinement and the associated social isolation create a stressful, potentially lengthy situations that has been proven to have several psychological consequences. Given the potential benefits that certain psychedelic drugs have shown for the treatment of psychological disorders, this study aimed to assess the impact of lifetime psychedelic drug use on mental health in relation to the first strict lockdown adopted by various countries (April-July 2020).Methods: Subjects completed an online survey that inquired about sociodemographic factors, activities, and lifestyle factors during confinement, as well as health and mental health related factors. Subjects were asked about their lifetime use of psychedelic drugs (MDMA, ayahuasca, psilocybin-containing mushrooms, LSD, peyote, San Pedro, Bufo alvarius or 5-MeO-DMT, and others), being classified as regular users (more than once per 6 months), occasional users, or non-users. The survey included psychometric tests used to assess psychological distress, peritraumatic stress, social support, psychopathological symptoms, and personality. Linear regressions were performed with psychedelic drug users as the independent variable and psychometric factors as the outcomes, while correcting for age, gender, language, religion, spirituality, and use of non-psychedelic drugs.Results: The study included 2,974 English, Portuguese, and Spanish speakers (497 regular users of psychedelic drugs, 606 occasional users, and 1,968 non-users). On average, respondents were 36 years old and 70% were female. Psychedelic drug users, especially regular ones, reported less psychological distress, less peritraumatic stress, and more social support. Regarding personality measures, psychedelic drug users scored higher on the novelty-seeking and self-transcendence scales, and lower on cooperativeness.Conclusion: Our findings showed that regular users of psychedelic drugs had less psychological stress and some personality differences when compared to occasional users and non-users. This suggests that either the use of psychedelics might be a protective factor itself or people with certain previous traits are more prone to frequently using psychedelic drugs. Future prospective longitudinal research should investigate the underlying processes observed in this study to develop consistent hypotheses.