bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of a hypolipid diet in patients with primary antiphospholipid syndrome with dyslipidemia: a prospective study
Authors: Rodrigues Thays C. R. , de Oliveira Vaz Camila , Miranda Eliana C. M. , Pereira Marcos , da Silva Saraiva Sabrina , Annichino-Bizzacchi Joyce Maria , de Moraes Mazetto Bruna , Orsi Fernanda A. 
Published: August 2021

AbstractAlthough dyslipidemia is associated with poorer prognosis in antiphospholipid syndrome (APS), the management of lipid disorders can be challenging. While statins may increase the bleeding risk associated with anticoagulation, the effectiveness of hypolipid diet (HD) has not yet been established in patients with autoimmune disorders. In this study, we evaluated whether HD is associated with decreases in cholesterol levels in patients with thrombotic primary APS (t-PAPS) and dyslipidemia. Nutritional and lipid profiles were assessed before HD was initiated (baseline) and after 3 and 6 months with HD. A 24-h dietary recall was applied to assess the adherence to the diet. Forty-four patients were included, mean age was 43 years (± 12.93) and 65% were female. After HD was started, the intake of carbohydrates, lipids, saturated fats and cholesterol decreased, whereas dietary fiber intake increased. Levels of total cholesterol (TC) and non-high density lipoprotein cholesterol (non-HDL-C) decreased after 3 and 6 months of HD, as compared to baseline (P = 0.007 and P = 0.008). Low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) values did not change during the study period. The mean body mass index (BMI) decreased from 28.4 to 27.8 kg/m2 after six months of HD (p < 0.0001). In subgroup analysis, the effects of HD were more pronounced in patients with high TC, LDL-C or non-HDL-C levels at baseline and in those without obesity or hypertension. Nutritional intervention is feasible among t-PAPS and could be an alternative therapy to modulate lipid metabolism in this population.
Exogenous abscisic acid impacts the development of isolated immature endosperm in bread wheat
Authors: Chłosta Iwona , Kozieradzka-Kiszkurno Małgorzata , Kwolek Dagmara , Marcińska Izabela , Sieprawska Apolonia , Popielarska-Konieczna Marzena 
Published: August 2021

AbstractEndosperm in cereals such as wheat, is a part of the mature seeds and a valuable source of key substances for humans and animals. For this reason, the development of immature endosperm tissues in planta was the focus of this research. However, it is commonly known that tissue culture conditions can alter the developmental pathway of plant cells and can expose their potency. There is scarce information about research on isolated endosperm in wheat. The development of isolated immature endosperm in the winter bread wheat variety ‘Kobra’, depending on the media composition, is presented in this study. Abscisic acid (ABA) is a key plant growth regulator for proper seed development. The addition of exogenous ABA had a positive impact on the size and ultrastructural features in isolated endosperm, especially of the outer aleurone-like cells. Furthermore, the content of starch in the endosperm cultured on a medium with ABA did not significantly differ from that of caryopsis at the same age, in contrast to soluble carbohydrates. Fluorescein diacetate (FDA) staining and confocal microscopy observation confirmed the viability of the cells from the outer layers. The analysis of internucleosomal fragmentation of DNA in the explants suggests the induction of programmed cell death (PCD) and DNA degradation typical of necrosis. We concluded that the development of isolated immature endosperm in bread wheat depends on the composition of the media. Thus, it could be a model for in vitro studies of this specific storage tissue and its response to culture conditions in bread wheat.
Management of local recurrence after radical nephrectomy: surgical removal with or without systemic treatment is still the gold standard. Results from a multicenter international cohort
Authors: Marchioni Michele , Sountoulides Petros , Furlan Maria , Mir Maria Carmen , Aretano Lucia , Rubio-Briones Jose , Alvarez-Maestro Mario , Di Nicola Marta , Bazán Alfredo Aguilera , Antonelli Alessandro , Simeone Claudio , Schips Luigi 
Published: August 2021

Abstract
Objective
To evaluate the survival outcomes of patients with local recurrence after radical nephrectomy (RN) and to test the effect of surgery, as monotherapy or in combination with systemic treatment, on cancer-specific mortality (CSM).

Methods
Patients with local recurrence after RN were abstracted from an international dataset. The primary outcome was CSM. Cox’s proportional hazard models tested the main predictors of CSM. Kaplan–Meier method estimates the 3-year survival rates.

Results
Overall, 96 patients were included. Of these, 44 (45.8%) were metastatic at the time of recurrence. The median time to recurrence after RN was 14.5 months. The 3-year cancer-specific survival rates after local recurrence were 92.3% (± 7.4%) for those who were treated with surgery and systemic therapy, 63.2% (± 13.2%) for those who only underwent surgery, 22.7% (± 0.9%) for those who only received systemic therapy and 20.5% (± 10.4%) for those who received no treatment (p < 0.001). Receiving only medical treatment (HR: 5.40, 95% CI 2.06–14.15, p = 0.001) or no treatment (HR: 5.63, 95% CI 2.21–14.92, p = 0.001) were both independently associated with higher CSM rates, even after multivariable adjustment. Following surgical treatment of local recurrence 8 (16.0%) patients reported complications, and 2/8 were graded as Clavien–Dindo ≥ 3.

Conclusions
Surgical treatment of local recurrence after RN, when feasible, should be offered to patients. Moreover, its association with a systemic treatment seems to warrantee adjunctive advantages in terms of survival, even in the presence of metastases.
Analysis of nocturnal desaturation waveforms using algorithms in patients with idiopathic pulmonary fibrosis
Authors: Yasuda Yuichiro , Nagano Tatsuya , Izumi Shintaro , Yasuda Mina , Tsuruno Kosuke , Tobino Kazunori , Nakata Kyosuke , Okamura Kayoko , Nishiuma Teruaki , Takatsuki Kiyonobu , Funada Yasuhiro , Ohnishi Hisashi , Yamamoto Masatsugu , Nishimura Yoshihiro , Kobayashi Kazuyuki 
Published: August 2021

Abstract
Purpose
Sleep-disordered breathing is recognized as a comorbidity in patients with idiopathic pulmonary fibrosis (IPF). Among them, nocturnal hypoxemia has been reported to be associated with poor prognosis and disease progression. We developed a diagnostic algorithm to classify nocturnal desaturation from percutaneous oxygen saturation (SpO2) waveform patterns: sustained pattern, periodic pattern, and intermittent pattern. We then investigated the prevalence of nocturnal desaturation and the association between the waveform patterns of nocturnal desaturation and clinical findings of patients with IPF.

Methods
We prospectively enrolled patients with IPF from seven general hospitals between April 2017 and March 2020 and measured nocturnal SpO2 and nasal airflow by using a home sleep apnea test. An algorithm was used to classify the types of nocturnal desaturation. We evaluated the association between sleep or clinical parameters and each waveform pattern of nocturnal desaturation.

Results
Among 60 patients (47 men) who met the eligibility criteria, there were 3 cases with the sustained pattern, 49 cases with the periodic pattern, and 41 cases with the intermittent pattern. Lowest SpO2 during sleep and total sleep time spent with SpO2 < 90% were associated with the sustained pattern, and apnea–hypopnea index was associated with the intermittent pattern.

Conclusion
We demonstrated the prevalence of each waveform and association between each waveform and sleep parameters in patients with IPF. This classification algorithm may be useful to predict the degree of hypoxemia or the complication of obstructive sleep apnea.
On the learning of addictive behavior: Sensation-seeking propensity predicts dopamine turnover in dorsal striatum
Authors: Chang Natalie Hong Siu , Kumakura Yoshitaka , Møller Arne , Linnet Jakob , Bender Dirk , Doudet Doris J. , Vafaee Manouchehr Seyedi , Gjedde Albert 
Published: August 2021

AbstractWe asked if sensation-seeking is linked to premorbid personality characteristics in patients with addictive disorders, or the characteristics follow the sensation-seeking activity. We interpreted the former as a state associated with normal rates of dopamine synthesis, and the latter as a trait of individuals with abnormally high rates of synthesis. We previously determined dopaminergic receptor density in striatum, and we now tested the hypothesis that an elevated dopaminergic condition with increased extracellular dopamine and receptor density follows increased dopamine synthesis capacity in highly sensation-seeking individuals, as measured by positron emission tomography of 18 men with tracer fluorodopa (FDOPA). We detected a site in left caudate nucleus where the volume of distribution of FDOPA-derived metabolites correlated negatively with FDOPA metabolite turnover, consistent with decreased metabolite breakdown in highly sensation-seeking subjects. High rates of sensation-seeking attenuated the dopamine turnover in association with a low rate of dopamine recycling, low dopamine oxidation, and elevated extracellular dopamine and receptors in caudate nucleus. In contrast, low rates of sensation-seeking were associated with rapid dopamine recycling, rapid dopamine oxidation, low extracellular dopamine, and low receptor density. We conclude that the modulation of dopaminergic neurotransmission associated with sensation-seeking is a state of sensation-seeking, rather than a trait of personality following abnormal regulation of dopaminergic neurotransmission.
When diversity leads to closed-mindedness: Cognitive factors explain the effects of perceived diversity
Authors: Schumpe Birga M. , Bélanger Jocelyn J. , Nisa Claudia F. , Pierro Antonio 
Published: August 2021

AbstractThis paper makes a case for explaining diversity effects through cognitive factors as compared to demographic or other differences in backgrounds. We argue that studying perceived diversity in conjunction with diversity beliefs can explain positive and negative effects through a motivated opening or closing of the mind (Need for Cognitive Closure, NFCC). NFCC is the motivation to avoid uncertainty and ambiguity. In Study 1, we experimentally demonstrate that asking participants to think about differences among their coworkers increases their NFCC. Study 2 shows that greater uncertainty about social norms in the workplace is positively related to NFCC. Study 3 confirms the mediating role of NFCC in explaining divergent thinking attitudes in expatriates working in various multicultural cities around the world. Study 4 demonstrates that perceived diversity is positively associated with NFCC when people hold negative beliefs about diversity, whereas positive beliefs mitigate this effect. Lastly, Study 5 shows that the interaction between perceived diversity and diversity beliefs is further moderated by task type. Taken together, the present research highlights the importance of studying cognitive factors to explain diversity effects.
Modelling other agents through evolutionary behaviours
Authors: Zeng Yifeng , Ran Qiang , Ma Biyang , Pan Yinghui 
Published: August 2021

AbstractModelling other agents is a challenging topic in artificial intelligence research particularly when a subject agent needs to optimise its own decisions by predicting their behaviours under uncertainty. Existing research often leads to a monotonic set of behaviours for other agents so that a subject agent can not cope with unexpected decisions from the other agents. It requires creative ideas about developing diversity of behaviours so as to improve the subject agent’s decision quality. In this paper, we resort to evolutionary computation approaches to generate a new set of behaviours for other agents and solve the complicated agents’ behaviour search and evaluation issues. The new approach starts with the initial behaviours that are ascribed to the other agents and expands the behaviours by using a number of genetic operators in the behaviour evolution. This is the first time that evolutionary techniques are used to modelling other agents in a general multiagent decision framework. We examine the new methods in two well-studied problem domains and provide experimental results in support.
Biosemiotic Achievement Award for the Year 2020
Authors: Rodríguez Higuera Claudio Julio , Tønnessen Morten 
Published: August 2021

AbstractThe Annual Biosemiotic Achievement Award was established at the annual meeting of the International Society for Biosemiotic Studies (ISBS) in 2014, in conjunction with Springer and Biosemiotics. It seeks to recognize papers published in the journal that present novel and potentially important contributions to biosemiotic research, its scientific impact and its future prospects. Here the winner of the Biosemiotic Achievement Award for 2020 is announced: The award goes to Filip Jaroš and Matěj Pudil for the article “Cognitive systems of human and non-human animals: At the crossroads of phenomenology, ethology and biosemiotics”.
Regional Cerebellar Volume Loss Predicts Future Disability in Multiple Sclerosis Patients
Authors: Parmar Katrin , Fonov Vladimir S. , Naegelin Yvonne , Amann Michael , Wuerfel Jens , Collins D. Louis , Gaetano Laura , Magon Stefano , Sprenger Till , Kappos Ludwig , Granziera Cristina , Tsagkas Charidimos 
Published: August 2021

AbstractCerebellar symptoms in multiple sclerosis (MS) are well described; however, the exact contribution of cerebellar damage to MS disability has not been fully explored. Longer-term observational periods are necessary to better understand the dynamics of pathological changes within the cerebellum and their clinical consequences. Cerebellar lobe and single lobule volumes were automatically segmented on 664 3D-T1-weighted MPRAGE scans (acquired at a single 1.5 T scanner) of 163 MS patients (111 women; mean age: 47.1 years; 125 relapsing–remitting (RR) and 38 secondary progressive (SP) MS, median EDSS: 3.0) imaged annually over 4 years. Clinical scores (EDSS, 9HPT, 25FWT, PASAT, SDMT) were determined per patient per year with a maximum clinical follow-up of 11 years. Linear mixed-effect models were applied to assess the association between cerebellar volumes and clinical scores and whether cerebellar atrophy measures may predict future disability progression. SPMS patients exhibited faster posterior superior lobe volume loss over time compared to RRMS, which was related to increase of EDSS over time. In RRMS, cerebellar volumes were significant predictors of motor scores (e.g. average EDSS, T25FWT and 9HPT) and SDMT. Atrophy of motor-associated lobules (IV-VI + VIII) was a significant predictor of future deterioration of the 9HPT of the non-dominant hand. In SPMS, the atrophy rate of the posterior superior lobe (VI + Crus I) was a significant predictor of future PASAT performance deterioration. Regional cerebellar volume reduction is associated with motor and cognitive disability in MS and may serve as a predictor for future disease progression, especially of dexterity and impaired processing speed.
Lipogenic Potency of Individual Perfluorinated Alkyl Acids (PFAAs) and Persistent Organic Pollutant (POP) Mixtures at Human Blood-Based Exposure Levels on Adipogenesis in 3T3-L1 Cells
Authors: Xie Y. , Berntsen H. F. , Zimmer K. E. , Ropstad E. , Verhaegen S. , Connolly L. 
Published: August 2021

AbstractIn recent decades, the incidence of metabolic disorders has increased internationally. This increase has been linked to exposure to persistent organic pollutants (POPs), but little is known about the metabolic effects of realistic human exposure mixtures at relevant concentrations. In this study we tested if POPs, representing real-life exposure profiles and concentrations, were able to disrupt development and functions of adipose tissue in a direct way. The lipogenic potency of a POP mixture modelled on levels found in human blood as detected in the Scandinavian population was assessed. The Total mixture comprises 29 compounds divided over three groups: chlorinated (Cl), brominated (Br) and perfluorinated compounds (PFAA). Individual PFAA chemicals, the Total mixture and sub-mixtures (Cl, Br, PFAA, Cl + Br, Cl + PFAA and Br + PFAA) at five (× 1/10, × 1, × 50, × 100 and × 500) human blood levels were tested in an optimized high content analysis (HCA) 3T3-L1 adipogenesis assay. All exposures promoted adipocyte formation in 3T3-L1 cells at concentrations equivalent to × 1/10 human blood levels. PFAAs promoted lipid accumulation in 3T3-L1 cells at 33.6 pM (PFUnDA) and 390,460 pM (PFHxS). The Total mixture, and the Cl, PFAA, Cl + Br and Cl + PFAA sub-mixtures, started to promote lipid accumulation at × 1/10 human blood levels. This in vitro bioassay study assessed the adipogenic effects of POP mixtures modelled on real-life human exposure levels. The findings highlight that such exposures may alter adipose tissue development and function, thus potentially playing a role in the globally increasing escalation of metabolic disorders.
Autonomous Driving and Public Reason: a Rawlsian Approach
Authors: Brändle Claudia , Schmidt Michael W. 
Published: August 2021

AbstractIn this paper, we argue that solutions to normative challenges associated with autonomous driving, such as real-world trolley cases or distributions of risk in mundane driving situations, face the problem of reasonable pluralism: Reasonable pluralism refers to the fact that there exists a plurality of reasonable yet incompatible comprehensive moral doctrines (religions, philosophies, worldviews) within liberal democracies. The corresponding problem is that a politically acceptable solution cannot refer to only one of these comprehensive doctrines. Yet a politically adequate solution to the normative challenges of autonomous driving need not come at the expense of an ethical solution, if it is based on moral beliefs that are (1) shared in an overlapping consensus and (2) systematized through public reason. Therefore, we argue that a Rawlsian justificatory framework is able to adequately address the normative challenges of autonomous driving and elaborate on how such a framework might be employed for this purpose.
Distance estimation of howling golden jackals (Canis aureus) using relative sound level
Authors: Graf Lukas , Hatlauf Jennifer 
Published: August 2021

AbstractGolden jackals (Canis aureus) display a complex repertoire of calls, utilized in different communication types (e.g., marking territories, attraction of mating partners). Resident golden jackal groups can successfully be detected by active bioacoustic stimulation, as well as with passive recording devices. For monitoring, basic knowledge of the calls of the focal species and potential restrictions and strengths of the monitoring devices should be considered. We therefore tested possible applications of a low-budget autonomous recording unit for bioacoustic golden jackal monitoring and examined the following research questions: How far can group calls be detected? Can the distance to the recording device be estimated? To answer these questions, we placed 11 AudioMoth recording devices in a linear transect to record live imitated and replayed howls. For the estimation of the number of responding animals, the number of howling individuals was determined based on the maximum number of simultaneously visible fundamental frequencies in a spectrogram. To predict the distance of the playback howls to the recording devices, the relative sound level (RSL) of each call was measured and fitted in linear models. Reliable distance estimations using RSL were possible up to 400 m. Estimated number of responding animals showed a negative relationship with distance. Our results present a baseline for future studies and show that AudioMoths can be a helpful asset in distance estimation of golden jackal packs—both in passive but also active monitoring.
On the pillars of Functional Analysis
Authors: Velasco M. Victoria 
Published: August 2021

AbstractMany authors consider that the main pillars of Functional Analysis are the Hahn–Banach Theorem, the Uniform Boundedness Principle and the Open Mapping Principle. The first one is derived from Zorn’s Lemma, while the latter two usually are obtained from Baire’s Category Theorem. In this paper we show that these three pillars should be either just two or at least eight, since the Uniform Boundedness Principle, the Open Mapping Principle and another five theorems are equivalent, as we show in a very elemental way. Since one can give an almost trivial proof of the Uniform Boundedness Principle that does not require the Baire’s theorem, we conclude that this is also the case for the other equivalent theorems that, in this way, are simultaneously proved in a simple, brief and concise way that sheds light on their nature.
Hydrothermal carbonization of fructose—effect of salts and reactor stirring on the growth and formation of carbon spheres
Authors: Jung Dennis , Duman Gözde , Zimmermann Michael , Kruse Andrea , Yanik Jale 
Published: August 2021

AbstractHydrothermal carbonization (HTC) has become a promising technology for the production of hydrochar and carbon spheres. Several studies indicate a strong dependency of the reaction conditions on the sphere diameter. The usage of additives, such as salts, is one possibility to increase the size of the spheres. However, the growth mechanism which leads to larger particles is not fully understood. In this work, kinetic studies of HTC with fructose were performed with different salts as additives. The growth of the particles (the increase in size) has been compared to the formation rates (increase in yield) of hydrochar by using the reaction rate constants from the kinetic model. The results indicate that the acceleration of the growth rate is independent of the formation rate. It is therefore assumed that coagulation, as a growth mechanism, took place. With longer reaction times, the particles reached a stable particle size, independently from the added salts; therefore, it was assumed that the particles underwent some sort of solidification. The state of matter can therefore be described as an intermediate state between liquid and solid, similar to mesophase pitch. Experiments with a stirrer resulted in squashed particles, which supports the model, that the particles exhibit emulsion-like behavior.