bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amount of generators of reactive oxygen species as a marker of organism damage on the background of experimental limb ischemia-reperfusion
Authors: Volotovska Nataliya 
Published: June 2021

Massive blood loss resulting in hemorrhagic shock requires the use of a hemostatic tourniquet. According to the literary sourced using of tourniquet for 2 hours is safe, but the newest investigations have shown ambiguous consequences for the body, coused by both local changes in the tissues under the tourniquet’s pressure, and the outflow of metabolic products into the general bloodstream from primarly ischemic limb.The aim was to identify the interralation between the level of production of reactive oxygen species by neutrophils of peripheral blood due to ischemia-reperfusion of the limb, as well as its combination with volumetric blood loss or mechanictal trauma.Materials and methods. The experiment was perfomed on 260 white male rats (200-250 g), which were divided into 5 groups: control, EG-1 – simulation of isolated limb ischemia-reperfusion (IR), EG-2 – simulation of isolated volumetric blood loss, EG -3 – combination of limb IR with blood loss, EG-4 – modeling of isolated thigh mechanical injury, EG-5 – combination of limb IR and mechanical injury. The percentage of neutrophils-producers of reactive oxygen species (ROS) was determined in the blood by flow cytofluometry.Results. It was found that ischemia-reperfusion of the limb, acute massive blood loss and their combination led to an increase in the number of ROS producers in the peripheral blood in all study periods. In the EG-2 on 1st and 3rd days it was higher than in the KG in 2,41 times and in 2,39 times accordingly, and also on 7th day exceeded level of the KG in 2,39 times and remained raised in 2 times on 14th day . In the EG-3 on the 1st day after injury exceeded the CG data in 2,5 times, then slightly decreased and exceeded the CG level in 2,3 times on the 3rd day. However, on the 7th and 14th day the index exceeded the CG level in 2,6 times and 3,3 times. The peculiarities which indicate the effect of mutual burden was that on the 14th day the level of ROS producers in the EG-3 was statistically significantly higher compared to the EG-1 in 3 times, and compared to the EG-2 – by 63,7%. Also, on the 14th day, the level of ROS in the EG-5 was in 2,4 times higher than the data of the EG-1, and by 58,3% higher than the data of the EG-4. In this case, after modeling only the ischemia-reperfusion of the limb, the figure was increased till the 14th day, on which it beame close to the initial rate.
Flexible, video-rate, and aberration-compensated axial dual-line scanning imaging with field-of-view jointing and stepped remote focusing
Authors: Jin Rui , Yu Yalan , Shen Dan , Luo Qingming , Gong Hui , Yuan Jing 
Published: June 2021

Parallel dual-plane imaging with a large axial interval enables the simultaneous observation of biological structures and activities in different views of interest. However, the inflexibility in adjusting the field-of-view (FOV) positions in three dimensions and optical sectioning effects, as well as the relatively small effective axial range limited by spherical aberration, have hindered the application of parallel dual-plane imaging. Herein, we propose a flexible, video-rate, and defocus-aberration-compensated axial dual-line scanning imaging method. We used a stepped mirror to remotely generate and detect dual axial lines with compensation for spherical aberration and FOV-jointing to rearrange into a head-to-head line for high-speed optical sectioning acquisition. The lateral and axial positions of the two FOVs could be flexibly adjusted before and during imaging, respectively. The method also allows the adjustment of optical sectioning effects according to specific experimental requirements. We experimentally verified the consistent imaging performance over an axial range of 300 μm. We demonstrated high throughput by simultaneously imaging Brownian motions in two

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FOVs with axial and lateral intervals of 150 μm and 240 μm, respectively, at 24.5 Hz. We also showed potential application in functional imaging by simultaneously acquiring neural activities in the optic tectum and hindbrain of a zebrafish brain. The proposed method is, thus, advantageous compared to existing parallel dual-plane imaging and potentially facilitates intravital biological study in large axial range.
Innovationstätigkeit imMittelstand: FuE nicht zwingend erforderlich
Authors: Brink Siegrun , Nielen Sebastian 
Published: June 2021

ZusammenfassungDie vorliegende Studie widmet sich der Innovationstätigkeit des Mittelstandes. Im Fokus stehen dabei nicht-forschende, mittelständischen Innovatoren. Diese meist kleinen Unternehmen sind vorrangig im Dienstleistungsbereich zu finden. Ziel der quantitativen Studie war es zu ermitteln, welche alternativen Strategien nicht-forschende Innovatoren umsetzen, um Innovationen zu generieren und die Frage zu beantworten, inwiefern diese eigene Forschung und Entwicklung ersetzen können. Die Ergebnisse unserer Untersuchung von 331 mittelständischen Unternehmen zeigen, dass der eigenen Forschungs- und Entwicklungstätigkeit für die Erstellung von Produktinnovationen eine entscheidende Rolle zukommt. Dabei nimmt die Relevanz eigener Forschungs- und Entwicklungstätigkeit mit dem Neuigkeitsgrad der Produktinnovation zu. Vor allem radikale Produktinnovationen bedingen eigene Forschungs- und Entwicklungstätigkeit. Prozess- und nicht-technologische Innovationen sind hingegen auch ohne eigene Forschung und Entwicklung realisierbar. Als erfolgreiche Maßnahmen zum Generieren von Innovationen abseits der eigenen Forschung und Entwicklung erweisen sich die Aus- und Weiterbildung der eigenen Belegschaft, sowie Maßnahmen zur Digitalisierung und die allgemeine Investitionstätigkeit.
How reliable are self-reported estimates of birth registration completeness? Comparison with vital statistics systems
Authors: Adair Tim , Lopez Alan D. 
Published: June 2021

BackgroundThe widely-used estimates of completeness of birth registration collected by Demographic and Health Surveys (DHS) and Multiple Indicator Cluster Surveys (MICS) and published by UNICEF primarily rely on registration status of children as reported by respondents. However, these self-reported estimates may be inaccurate when compared with completeness as assessed from nationally-reported official birth registration statistics, for several reasons, including over-reporting of registration due to concern about penalties for non-registration. This study assesses the concordance of self-reported birth registration and certification completeness with completeness calculated from civil registration and vital statistics (CRVS) systems data for 57 countries.MethodsSelf-reported estimates of birth registration and certification completeness, at ages less than five years and 12–23 months, were compiled and calculated from the UNICEF birth registration database, DHS and MICS. CRVS birth registration completeness was calculated as birth registrations reported by a national authority divided by estimates of live births published in the United Nations (UN) World Population Prospects or the Global Burden of Disease (GBD) Study. Summary measures of concordance were used to compare completeness estimates.FindingsBirth registration completeness (based on ages less than five years) calculated from self-reported data is higher than that estimated from CRVS data in most of the 57 countries (31 countries according to UN estimated births, average six percentage points (p.p.) higher; 43 countries according to GBD, average eight p.p. higher). For countries with CRVS completeness less than 95%, self-reported completeness was higher in 26 of 28 countries, an average 13 p.p. and median 9–10 p.p. higher. Self-reported completeness is at least 30 p.p. higher than CRVS completeness in three countries. Self-reported birth certification completeness exhibits closer concordance with CRVS completeness. Similar results are found for self-reported completeness at 12–23 months.ConclusionsThese findings suggest that self-reported completeness figures over-estimate completeness when compared with CRVS data, especially at lower levels of completeness, partly due to over-reporting of registration by respondents. Estimates published by UNICEF should be viewed cautiously, especially given their wide usage.
Dosztojevszkij íráspoétikájához
Authors: Lovizer Lilla 
Published: June 2021

A Megalázottak és megszomorítottak című Dosztojevszkij-regényt ma az író kevésbé népszerű művei között szokás számontartani; mintegy a dokumentarista kéziratra épülő-, illetve a sok tekintetben ars poetikus elbeszélés kiforratlan, átmeneti képződményeként. A szakirodalom számára azonban ezzel együtt is az életmű olyan egyedülálló darabja, mely a hatvanas évek elejére beálló alkotói szemléletváltást a maga egészében jeleníti meg.
Ebben a művében Dosztojevszkij nyíltan szembefordul saját negyvenes évekbeli, romantikus múltjával, s kíméletlen karikatúrát fest a „schillerista idealizmus” különféle megnyilvánulási formáiról. Épp emiatt fontos azonban látni azt is, hogy ebben az eljárásban – a regény közismerten összetett irodalmi kódoltsága mellett – legnagyobb segítségére még mindig ugyanaz az E. T. A. Hoffmann szolgál, akit Dosztojevszkij kamaszkora óta szakadatlanul csodált, s akinek legjellemzőbb szövegalkotó technikái eleve is a korai német romantika esztétikai- filozófiai nézeteihez való szkeptikus-ironikus viszonyt tükrözték. Jelen tanulmány kifejezetten a hozzá fűződő intertextuális jelentésképződést vizsgálja, arra a kérdésre keresve választ, hogy miként generálják a különféle Hoffmann-szövegek a regényi szüzsét; mennyiben élnek tovább és/vagy hogyan íródnak át (destruálódnak) Dosztojevszkij művében a tőle származó romantikus minták.
Evaluation of the effectiveness of surgical methods for the treatment of recurrent lumbar disc herniation: a cohort retrospective study
Authors: Kravtsov M. N. , Kruglov I. A. , Mirzametov S. D. , Seleznev A. S. , Alekseyeva N. P. , Manukovskiy V. A. , Gaidar B. V. , Svistov D. V. 
Published: June 2021

Objective.To compare the effectiveness of surgical methods for treating patients with recurrent lumbar disc herniation.Material and Methods.The sample consisted of 160 patients operated on in 2014–2019 for recurrent lumbar disc herniation by percutaneous endoscopic discectomy (Group 1), microsurgical discectomy (Group 2), single-level transforaminal interbody fusion (Group 3) and single-level total intervertebral disc replacement (Group 4). The effectiveness of surgical treatment was evaluated using the NRS-11, ODI, and MacNab questionnaires.Results.Assessment of the pain syndrome severity and the vital activity level of patients revealed significant (p < 0.05) differences in favor of total intervertebral disc replacement. Excellent and good outcomes after arthroplasty according to MacNab criteria were noted in all patients in this group. Similar outcomes were reported in 77.5 % (31/40) of patients in the TLIF group, in 75.1 % (24/32) of patients in the percutaneous endoscopic discectomy group and in 72.6 % (45/62) of patients in the microdiscectomy group. The operation time and length of hospital stay were shorter in the endoscopic and microsurgical discectomy groups (p < 0.001). However, the lower incidence of complications and reoperations was observed in groups of posterior interbody fusion and arthroplasty (p > 0.05).Conclusion.Arthroplasty with the M6-L implant expands the possibilities of surgery for recurrent lumbar disc herniation. Total intervertebral disc replacement and posterior interbody fusion for recurrent lumbar disc herniation are more effective in comparison with decompressive operations, which is reflected in the improvement of clinical treatment outcomes, reduction of perioperative complications and frequency of repeated interventions.
Single- and multistage surgical treatment of patients with degenerative sagittal imbalance
Authors: Baikov E. S. , Peleganchuk A. V. , Sanginov A. J. , Leonova O. N. , Krutko A. V. 
Published: June 2021

Objective. To analyze the nearest clinical and radiological results of simultaneous and staged surgical treatment of patients with degenerative sagittal imbalance.Material and Methods. Retrospective monocentric cohort study included analysis of data from 54 patients who underwent simultaneous combination of surgical methods with obligatory corrective anterior fusion at the L4–L5 or at L4–L5 and L5–S1 levels (Group I, n = 27) or similar surgical intervention though divided into stages with an interval of 5 days or more (Group II, n = 27). A comparison of clinical, radiological, and operational data during inpatient treatment was carried out.Results. The duration of surgery was 410.93 ± 76.34 minutes in Group I and 594.63 ± 102.61 minutes in Group II (p = 0.000001); the blood loss was 926.67 ± 378.63 ml versus 1345.19 ± 522.97 ml, respectively (p = 0.001575). Postoperative clinical and radiological parameters did not differ between groups: VAS back (p = 0.248647), VAS leg (p = 0.196140), PT (p = 0.115965), SVA (p = 0.208449), LL (p = 0.023654), LDI (p = 0.931646), PI-LL (p = 0.693045), GAP (p = 0.823504), and restoration of the ideal Russoly type (p = 0.111476). The incidence of perioperative complications in groups was comparable: 17 (62.96 %) in Group I and 15 (55.56 %) in Group II (p = 0.583171). Patients with a high Charlson comorbidity index had a significantly higher incidence of complications (p = 0.023471). The index of surgical invasiveness in Group I had a significant correlation with the total number of complications (r = 0.421332).Conclusion. Clinical and radiological results and the incidence of complications are comparable between single- and multistage approaches to correct sagittal balance disorders. In staged treatment, the total duration of surgery and the volume of blood loss are significantly higher. With a high Charlson comorbidity index and Mirza surgical invasiveness index, a multistage approach to the treatment of patients with sagittal imbalance is preferred.
Pemaknaan Hidup Survivor Kanker Serviks selama Terapi Pengobatan: Literature Review
Authors: Roberto Regina Aprilia , Hidayati Wahyu 
Published: June 2021

Introduction: Cervical cancer treatment process proves to make women experiencing emotional distress that brings new problems in life. Women with cervical cancer who undergo treatment suffer affecting all aspects of life that impact on the meaning of life. There is limited literature review regarding life meaning resources and technique used by women with cervical cancer who undergo treatment. The aim of this study is to find out description about the meaningfulness in life of cervical cancer survivor during treatment period based on sources and technique of finding meaning. Methods: This study used literature review method. The literature search engines used are SCOPUS, SINTA and Google Scholar. The inclusion criteria of article were articles in Indonesian or English, containing sources and techniques for finding meaning in abstract, respondents cervical cancer survivor and published from 2011 to 2020. Results: Eleven articles show the existence of meaning in life build upon sources of meaning in life including creative, experimental, attitudinal, and hopeful values. Moreover, there are techniques in seeking meaning involving self-understanding, positive action, familiarity with relationships, deepening the values of the meaning of life and worship. Conclusion: The beginning of treatment process results feelings of meaningless, but efforts to make sense of life remain. Family support and spirituality were found to be the things that give the most meaning for cervical cancer survivors to survive.
Endocrine and Body Composition Changes Across a Competitive Season in Collegiate Speed-Power Track and Field Athletes
Authors: Mangine Gerald T. , Mangine Gerald T. , Eggerth Andrew , Gough Jeremy , Stratton Matthew T. , Feito Yuri , VanDusseldorp Trisha A. 
Published: June 2021

Abstract
Mangine, GT, Eggerth, A, Gough, J, Stratton, MT, Feito, Y, and VanDusseldorp, TA. Endocrine and body composition changes across a competitive season in collegiate speed-power track and field athletes. J Strength Cond Res 35(8): 2067–2074, 2021—Maintaining lean mass is important for track and field (TF) athletes who compete in speed-power events, but little is known about how lean mass and related hormones might change over an 8- to 10-month collegiate season. Therefore, to monitor changes in free testosterone (T), cortisol (C), and body composition in TF athletes across their entire competitive season, 9 female (20.3 ± 1.2 years, 169 ± 5 cm, and 67.6 ± 8.5 kg) and 7 male (21.1 ± 2.0 years, 181 ± 9 cm, and 77.3 ± 5.9 kg) Division I TF athletes provided resting and fasted blood samples at the onset of their indoor season (baseline), before and on returning from the indoor conference championships (ICCs), at the beginning and end of a heavy midseason training week (HVY), and before leaving for the National Collegiate Athletic Association (NCAA) Championships. Body composition was also assessed at each of these periods using a 4-compartment model. Except for a 20% reduction (p = 0.030) from ICCs to the onset of HVY in men only, linear mixed models with repeated measures did not reveal any changes in hormone concentrations. Compared with baseline, an overall increase in fat-free mass was observed at HVY (∼2.74%, p = 0.023) before it reduced by 3.81% before the NCAA Championships (p = 0.022). Despite variations in training and competition, resting concentrations of hormones indicative of anabolic status remained relatively consistent over the course of an entire season in speed-power TF athletes. Coaches and athletes may consider monitoring these variables to assess the athlete's response to the changing demands of a competitive season.
Biología y medicina reduccionistas: Una reflexión sobre sus raíces epistemológicas y sus limitaciones
Authors: Muñoz Rubio Julio 
Published: June 2021

La masiva inoculación de vacunas preventivas del COVID es el más reciente acontecimiento en el que las empresas farmacéuticas y la ciencia médica dependiente de ellas imponen su visión de lo que deben ser los tratamientos preventivos. Estos han estado históricamente basados en una concepción reduccionista y mecanicista del cuerpo humano y de los procesos de la vida, que está siendo crecientemente cuestionada en favor de concepciones más integrativas, relacionales y de la totalidad en el mundo vivo. Sin menospreciar los logros que aquella concepción médica ha tenido, sí se considera indispensable aprovechar la situación sanitaria mundial presente para abrir una reflexión crítica sobre los fundamentos metodológicos de la medicina hegemónica; exhibir tanto sus aciertos como sus limitaciones y dirigir estos esfuerzos a la construcción de una medicina ontológico-epistémicamente plural y despojada de su dependencia de los grandes consorcios farmacéuticos.
The effect of borate bioactive glass on the printability of methylcellulose-manuka honey hydrogels
Authors: Schuhladen Katharina , Bednarzig Vera , Rembold Nadine , Boccaccini Aldo R. 
Published: June 2021

Abstract
3D printing offers the possibility to generate complex and individualized constructs (scaffolds) for applications in tissue engineering. This is viable by using suitable inks based on advanced biomaterials. Methylcellulose (MC), a highly biocompatible biomaterial, can be combined with manuka honey (H) to fabricate a thermo-sensitive hydrogel. Besides providing favorable biological effects, H can also be used as a natural cross-linking agent. Furthermore, the addition of bioactive glass (BG) to the ink could improve its mechanical and bioactive properties. In this study, a composite based on MC as matrix incorporating H and particulate borate BG as filler, was investigated as ink for 3D printing. Besides the improvement of the inks’ printability owing to the addition of BG, the printed scaffolds exhibited suitable swelling behavior and mechanical properties. Moreover, cell biology tests demonstrated the potential of the composite for biofabrication and applications in tissue engineering, which should be further explored.

Graphic abstract
Empirical Acoustic Source Model for Chemical Explosions in Air
Authors: Kim Keehoon , Rodgers Arthur R. , Garces Milton A. , Myers Stephen C. 
Published: June 2021

ABSTRACT
Chemical explosions generate pressure disturbances in air that radiate as nonlinear shock waves near the source and transition into acoustic waves with distance. Because low-frequency acoustic waves generally travel large distances without significant loss of energy, they are often used for explosion monitoring and yield estimation. However, quantitative relationships between acoustic energy and explosion yields are required for accurate yield estimation. Here, we develop an empirical acoustic source model for chemical explosions from experimental data. The empirical model returns the acoustic pressure waveform for the detonation of 1 kg of trinitrotoluene, which is conventionally used to represent the explosive release of 4.184 MJ of explosion energy. The full-waveform model can be used to predict acoustic signals for an arbitrary yield of a high-explosive detonation based on the standard scaling law and to estimate acoustic energies in a specific frequency range. We evaluate the accuracy of the acoustic source model independently by estimating the yield of other explosive events that are not included in the model development. Statistical characteristics of the model and their implications for the uncertainty quantification of estimated yields are discussed.