bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tetrachloroaurate (III)–induced Oxidation Increases Non-thermal Plasma-induced Oxidative Stress
Authors: Okazaki Yasumasa , Sasaki Kanako , Ito Nanami , Tanaka Hiromasa , Matsumoto Ken-Ichiro , Hori Masaru , Toyokuni Shinya 
Published: September 2021

Abstract
Non-thermal plasma (NTP) devices have been explored for medical applications. NTP devices discharge electrons, positive ions, ultraviolet, and reactive oxygen species (ROS) and reactive nitrogen species (RNS), such as the hydroxyl radical (●OH), singlet oxygen (1O2), superoxide (O2●−), hydrogen peroxide (H2O2), ozone, and nitric oxide, at near-physiological temperature. At preclinical stages or in human clinical trials, NTP promotes blood coagulation, eradication of bacterial, viral, and biofilm-related infections, wound healing, and cancer cell death. Here, we observed that ferric, vanadium, and gold(III) ions, measured by 2-thiobarbituric acid-reactive substances (TBARS) in combination with NTP exposure, significantly elevated lipid peroxidation. Using 3,3,5,5-tetramethyl-1-pyrroline-N-oxide (M4PO) as a spin probe in electron paramagnetic resonance (EPR), we observed that tetrachloroaurate (III) yielded an M4PO-X spin adduct. Tetrachloroaurate-induced oxidation was attenuated efficiently by reduced (GSH) and oxidized glutathione (GSSG), while glycine (Gly) and L-glutamate (Glu), components of GSH, were ineffective. Furthermore, GSH and GSSG efficiently suppressed tetrachloroaurate-induced lipid peroxidation, while Gly and Glu were ineffective in suppressing TBARS elevation. These results indicate that tetrachloroaurate-induced oxidation is attenuated by GSH as well as GSSG. Further studies are warranted to elucidate the redox reactions between metal ions and biomolecules to advance the clinical application of NTP.
Overlapping anti-N-methyl-D-aspartate receptor (NMDAR) Encephalitis With Neuromyelitis Optica Spectrum Disorders: A Case Report
Authors: Pan Jialin , Ovlyakulov Begench , zhou Lili 
Published: September 2021

Abstract
BackgroundAnti-N-methyl-D-aspartate receptor (NMDAR) encephalitis can coexist with neuromyelitis optica spectrum disorder (NMOSD). Patients with overlapping anti-NMDAR encephalitis with positive NMDAR antibodies and aquaporin 4 immunoglobulin G (AQP4-IgG)-seropositive NMOSD are rare but should not be ignored.Case presentationThis report describes a unique case of anti-NMDAR encephalitis coexisting with NMOSD is presented. A 27-year-old male presented with blurred vision, cognitive impairment, psychosis, dysphagia, gait instability and urinary incontinence. Brain magnetic resonance imaging (MRI) showed abnormal signals in the right cerebellar hemisphere, temporal lobe, and corpus callosum. NMDAR antibodies were positive in the CSF. AQP4-IgG antibodies were positive in the serum. The patient's condition was stable following intravenous gamma globulin, corticosteroids, immunosuppressants and symptomatic treatments. ConclusionsThis case provides further evidence for the occurrence of anti-NMDAR encephalitis overlapping NMOSD with AQP4-IgG-seropositive in a Chinese patient. However, the mechanisms underlying the occurrence of double positive antibodies remain elusive.
Examining the impact of social stressor stimuli in eliciting physiological reactivity in children and adolescents with autism spectrum disorder: A systematic review and meta-analysis protocol
Authors: Wong Agnes S. K. , Burns Samantha , Woodruff Earl 
Published: September 2021

Abstract
Background: Stress is not experienced the same by everyone. Some individuals, such as individuals with Autism Spectrum Disorder (ASD), are at risk of heightened sensitivity to stress responses. ASD is a neurodevelopmental disorder commonly characterized by deficits in social communication and social interaction. Among different stressor stimuli, social stressors particularly worth our attention due to the social and communication challenges inherent to ASD. This study aims to systematically evaluate different social stressor stimuli in eliciting physiological reactivity in ASD, focusing on the children and adolescent population. Methods: We designed a study protocol for this study and submitted it to PROSPERO for systematic review registration. Any studies with children and adolescents with ASD between the ages of 0-18 in clinical and community settings will be included. All types of social stressor interventions will be included. The intended outcomes will not be restrictive. The outcome of interest will include studies with physiological activity of the participants being measured, e.g., measures related to autonomic functioning, electrodermal functioning, and cortisol level. The primary literature sources will be across four electronic databases: Medline, Embase, PsycInfo, and CINAHL. The second source of literature will be across grey literature, including ProQuest Dissertations & Theses Global and across clinical trial registries. Hand searching of references will be performed on the reference lists of all included studies. Two volunteers pursuing postgraduate-level studies will independently search and screen potential studies for eligibility. Finally, all references considered by hand-searching will be reviewed by two researchers. The methodological quality of the research will be assessed by adopting the quality assessment used by a previous study. The assessment consists of four primary categories: descriptive validity, internal validity, external validity, and statistical conclusion validity. Discussion: Considering the inconsistent methodologies and findings in previous studies, a systematic review in this area is required. We are not aware of another systematic review discussing this specific issue. The findings will have important implications for clinical practice and research studies. We anticipate that the results will be of interest to multiple audiences, including the individuals with ASD, their families and caregivers, healthcare professionals, educators, and researchers. Systematic Review Registration: PROSPERO CRD42021244039
Finite Element Modeling and Experimental Validation of Microstructural Changes and Hardness Variation During Gas Metal Arc Welding of Aisi 441 Ferritic Stainless Steel
Authors: CARUSO SERAFINO , IMBROGNO STANO 
Published: September 2021

Abstract
Grain growth and hardness variation occurring in high temperature Heat Affected Zone (HAZ) during the welding processes are two thermal dependant aspects of great interest for both academic and industrial research activities. This paper presents an innovative Finite Element (FE) model capable to describe the grain growth and the hardness decrease that occur during the Gas Metal Arc Welding (GMAW) of commercial AISI 441 steel. The commercial FE software SFTC DEFORM-3DTM was used to simulate the GMAW process and a user subroutine was developed including a physical based model and the Hall-Petch (H-P) equation to predict grain size variation and hardness change. The model was validated by comparison with the experimental results showing its reliability in predicting important welding characteristics temperature dependant. The study provides an accurate numerical model (i.e. user subroutine, heat source fitting, geometry,…) able to successfully predict the thermal phenomena (i.e. coarsening of the grains and hardening decrease) that occur in the HAZ during welding process of ferritic stainless steel.
Cephalic Arch Restenosis Rates in Hemodialysis Patients with Brachiocephalic Fistulae: A Retrospective Multicenter Analysis of 3,301 Patients
Authors: Razdan Rishi N. , Rosenblatt Melvin , Jiao Yue , McLaughlin Nancy , Usvyat Len , Sor Murat , Larkin John 
Published: September 2021

Abstract
Background:

We evaluated restenosis rates at the cephalic arch after percutaneous angioplasty and stenting procedures in patients with brachial artery to cephalic vein arteriovenous fistula (BCAVF) hemodialysis access.
Methods:

We used data from adult hemodialysis patients treated at a national network of 44 outpatient interventional facilities during Oct 2011–2015. We included data from patients with BCAVF who received an exclusive angioplasty, or stent with angioplasty, for treatment of cephalic arch stenosis and had ≥ 1 subsequent evaluation of the cephalic arch. Median percent restenosis per month at cephalic arch and days between encounters was calculated from the 1st index to 2nd procedure, and for up to 4 subsequent encounters. Analyses were stratified by intervention and device types.
Results:

We identified a cohort of 3,301 patients (mean age 62.2 ± 13.9 years, 58.5% male, 33.2% white race) with a BCAVF who had an angioplasty, or stent, at the cephalic arch for an index and ≥ 1 follow-up procedure. Between the 1st index to 2nd procedure, patients who received an angioplasty (n = 2,663) or stent (n = 933) showed a median decrease of 18.9% and 16.5% in luminal diameter per month and a median time of 93 and 91 days between encounters, respectively. Restenosis and day rates were similar for standard versus high-pressure angioplasties. Bare metal stents showed 10.1 percentage point higher restenosis rate compared to stent grafts. Restenosis rates and time to restenosis were relatively consistent across subsequent encounters.
Conclusions:

Findings suggest hemodialysis patients with a BCAVF who require an angioplasty or stent to treat a stenosis at the cephalic arch will have stenosis reformed at a rate of 18.9% and 16.5% per month after the first intervention, respectively. Findings suggest patients are at risk of having significant lesions at the cephalic arch within 3 months after the previous intervention.
Surgical treatment of Temporal Lobe Epilepsy: comparative results of selective amygdalohippocampectomy versus anterior temporal lobectomy from a referral center in Brazil
Authors: Almeida Laryssa C Azevedo , Lobato Vanessa Alves , Santos Maria do Carmo Vasconcelos , de Moraes Aline Curcio , Costa Bruno Silva 
Published: September 2021

Abstract
IntroductionTemporal Lobe Epilepsy (TLE) is a high prevalence neurological disorder and tends to drug refractoriness. Surgery has emerged as a promising treatment for managing crises and a better quality of life for these patients. The objective of this work is to compare the surgical results in terms of seizures control concerning the surgical technique performed (Anterior temporal lobectomy (ATL) vs. Selective amygdalohippocampectomy (SAH)) in a cohort of 132 patients operated in an epilepsy reference center.Materials and methodsWe performed a retrospective study based on the review of medical records of 146 patients operated for TLE from 2008 to 2019 at the Santa Casa de Misericordia in Belo Horizonte, Brazil. Initially, 13 patients were excluded from the study due to insufficient medical record data or follow-up loss. We used the ILAE (International League Against Epilepsy) scale to classify seizure control after surgery. We compared the surgical groups using the survival and Kaplan-Maier curves.ResultsA total of 132 patients were evaluated in this study, with a mean follow-up time after surgery of 57.2 months (12-137). In our data analysis, we found that the group of patients undergoing ATL had a higher prevalence of being completely seizure-free (ILAE I) (57,1% vs. 31%) and a higher rate of satisfactory seizure control (88,6% vs. 69,3%) p =0.006.ConclusionThe literature is still controversial about seizure control results concerning the surgical technique used due to the lack of studies with a robust methodology for an adequate comparison. In our data analysis, we identified the superiority of ATL over SAH in seizure outcomes.
Continuous infusion ketamine as analgesia or sedation in mechanically ventilated adults in the intensive care unit: a scoping review
Authors: Richards Nicholas David , Howell Simon , Bellamy Mark , Mujica-Mota Ruben 
Published: September 2021

Abstract
IntroductionMechanical ventilation (MV) is a common and often live-saving intervention on the Intensive Care Unit (ICU). In order to facilitate this intervention, the majority of patients require medical sedation. Optimising sedation is one of the fundamentals of ICU care, and inadequate sedation (predominantly too deep) has consistently been associated with worse outcomes for patients.This article presents the protocol for a scoping review of published literature on the use of ketamine as a sedative to facilitate MV on ICU.The scoping review has been designed to answer the question ‘What is known about the use of ketamine as a continuous infusion to provide sedation in mechanically ventilated adults in the intensive care unit, and what gaps in the evidence exist?’ MethodsThe scoping review protocol has been designed using the Preferred Reporting Items for Systematic Reviews and Meta-analysis extension for Scoping Reviews (PRISMA-ScR) checklist and the JBI manual for evidence synthesis. Data will be extracted using a dedicated form, and reviewed by 2 reviewers.Results Results will be tabulated and presented along side descriptive summaries. A PRISMA flow diagram will also be generated.Ethics and DisseminationThis scoping review is designed to map out the literature using existing published articles and does not require ethical approval.Results will be submitted for publication in relevant peer-reviewed journals and to international meetings as well as disseminated to relevant professional groups.
Disease Named Entity Recognition (D-NER) Evaluation
Authors: Xie Xie-Yuan 
Published: September 2021

Abstract
Named Entity Recognition (NER) is a key task in Natural Language Processing (NLP). In medical domain, NER is very important phase in all end-to-end systems. In this paper, we investigate the performance of NER for disease (D-NER). TaggerOne was evaluated on 52 cardiovascular-related clinical case reports against hand annotation for diseases. Different training sets have been used to evaluate the performance of TaggerOne as a famous tool for NER in biomedical domain.
The Association Between Household Income, Food Security, and Prevalence of Chronic Kidney Disease in Elderly Patients
Authors: Huh Hyuk , Song Je Hun , Kim Hong Yeop , Koo Hoseok , Yoo Kyung Don 
Published: September 2021

Abstract
This study aimed to clarify the association between food security and the prevalence of chronic disease. We analyzed the variables of The Korea National Health and Nutrition Examination Survey V (2010–2012), and VI (2013–2015) while merging data of the food security questionnaire of four years. We included 15,945 participants, performed propensity score matched analysis by quartile of household income (i.e., low, low-mid, high-mid, high) and sex, and presented the results by age group. Systolic blood pressure and proportion of current smokers were significantly higher in the elderly group, compared with the middle-aged group. The prevalence of hypertension, diabetes mellitus (DM), metabolic syndrome, and chronic kidney disease (CKD) did not differ significantly by income level in the elderly group. The food security questionnaire revealed that food security insurance was significantly lower in the low-income level (1st quartile), compared with that in the high-income level (4th quartile). The logistic regression analysis for the association between the prevalence of chronic disease and food insecurity confirmed no significant association with hypertension and DM. Food insecurity might be associated with CKD prevalence, especially in the elderly population.
Implementing a Low-threshold Audio-only Telehealth Model for Medication-assisted Treatment of Opioid Use Disorder at a Community-based Non-profit Organization in Washington, D.C.
Authors: Yeo Ellis Jaewon , Kralles Hannah , Sternberg David , McCullough Dana , Nadanasabesan Ajetha , Mayo Richard , Akselrod Hana , Catalanotti Jillian 
Published: September 2021

Abstract
BackgroundThe COVID-19 pandemic has had especially devastating effects on people who use drugs. Due to pandemic protocols in the United States, medication-assisted treatment (MAT) regulations became more flexible, permitting our community-based nonprofit organization to transition its low-threshold MAT clinic to an audio-only telehealth model of care in 2020. Case PresentationThis case study describes our transition from a low-threshold community-based in-person MAT clinic to an audio-only telehealth model. We extracted data from electronic health records to describe patient characteristics and to calculate treatment retention rates. We measure the success of our intervention relative to published retention rates, both overall as well as for in-person and telehealth care. ConclusionsLow-threshold medication-assisted treatment in the care of people with opioid use disorder is essential to increasing treatment access and continuity. We found that an audio-only telehealth model was viable. Although we had decreased retention rates following the transition to an audio-only telehealth model, our rates remained excellent compared to published values for in-person MAT care. We call for advocacy and regulations to support continued use of telehealth services throughout and beyond the COVID-19 pandemic.
Hypertriglyceridemia during infectious mononucleosis
Authors: Páez-Guillán Emilio Manuel , Campos-Franco Joaquín , Alende-Sixto Mª del Rosario , Garitaonaindía-Díaz Yago , González-Quintela Arturo 
Published: September 2021

Abstract
Background

Hypertriglyceridemia can be observed in lymphoproliferative disorders. Epstein-Barr virus-induced infectious mononucleosis can be considered a self-limiting lymphoproliferative disorder. The aim of this study is to investigate serum triglyceride concentrations, associated factors, and time-course changes in patients with infectious mononucleosis.
Methods

We report on an adult patient with extreme hypertriglyceridemia (triglycerides > 1000 mg/dL) during infectious mononucleosis. We then reviewed the clinical records of 360 patients admitted to the hospital due to infectious mononucleosis (median age 19 years, range 15–87 years; 51.4% male). Serum triglyceride concentrations were compared with those of a control sample from the general population, aged 18–30 years (n = 75). A second measurement of serum triglyceride concentrations, obtained during convalescence (median of 30 days after the initial determination), was available for 160 patients.
Results

Triglyceride concentrations in the acute phase (median 156 mg/dL; range, 27–452 mg/dL) were significantly higher than those of controls (P < 0.001). A total of 194 patients (53.9%) showed hypertriglyceridemia (triglycerides > 150 mg/dL), which was more common in the older patients. A significant correlation was observed between serum triglycerides and white blood cell counts, total cholesterol levels, and markers of liver damage. Serum triglyceride concentrations tended to decrease during convalescence (P < 0.001) and were lower than the initial measurement in 83.7% of the cases. Conversely, total serum cholesterol concentrations during the acute phase were lower than those of the controls and increased during convalescence (P < 0.001).
Conclusions

Patients with severe (in-hospital) infectious mononucleosis frequently show mild, transient hypertriglyceridemia. Further studies are needed to elucidate the mechanisms underlying these findings.
Comparison of efficacy of laser and radio-wave methods of surgical treatment of patients with chronic rhinitis
Authors: Svistushkin V. M. , Shchennikova E. S. , Sinkov E. V. 
Published: September 2021

Introduction. Chronic rhinitis occurs more often in patients; it’s symptoms deteriorate their quality of life, affect sleeping, daily activity, and sometimes cause complications. The treatment depends on the clinical symptoms. In case of inefficiency of conservative therapy, surgery is indicated. Choosing an exact surgical instrument is still controversial.Objective. The aim of our study is to compare using semiconductor laser (wavelength 1.56 mkm) and radiofrequency (4 MHz) in patients with chronic rhinitis.Materials and methods. 60 patients with chronic drug-induced rhinitis aged 19–80 years were recruited and divided into two equal groups. All patients underwent surgical procedures: semiconductor laser (IRE-Polus) and radiofrequency (Ellman Surgitron) inferior nasal turbinate reduction. To assess and compare the healing process in two groups we used endoscopy and active anterior rhinomanometry. All patients filled out the SNOT-20 questionnaire. For the mucociliary clearance evaluation saccharin test was used. We observed patients during 12 months.Conclusion. Both, laser and radiofrequency, techniques are effective in patients with chronic rhinitis. In laser group shorter healing period was observed, what leads to rehabilitation shortening and life quality improvement.
The role and place of glucocorticosteroids in treatment of COVID-19 pneumonia without hypoxemia
Authors: Salukhov V. V. , Kryukov E. V. , Chugunov A. A. , Kharitonov M. A. , Rudakov Yu. V. , Lakhin R. E. , Dancev V. V. , Stepanenko I. A. , Gurba M. O. , Stepanova T. V. , Bolekhan A. V. , Arzhavkina L. H. 
Published: September 2021

Introduction. The article presents the problems of the use of glucocorticosteroids in the treatment of patients with coronavirus– associated pneumonia (COVID-19) without hypoxemia. The experience of the preemptive use of low doses of glucocorticosteroids in the treatment of such patients in a hospital is described. Simplification of a unified scheme of pathogenetic therapy with glucocorticosteroids in the above patients is urgent. The article highlights the effectiveness of the early use of low doses of glucocorticosteroids in the treatment of a specific cohort of patients with COVID-19.Objective. To assess the clinical efficacy and safety of early use of small doses of methylprednisolone in the comprehensive therapy of patients with moderate to severe COVID-19 pneumonia to prevent the development of complications and improve the outcomes of the disease.Materials and methods. The study included 40 hospitalized patients from 37 to 68 years (average age 52. years) with a diagnosis of moderate to severe COVID-19 pneumonia. Patients were randomized into two groups: the main group (n = 20) and the control group (n = 20). The main group additionally received methylprednisolone: 4 mg tablets, 7 tablets per day, divided into 2 doses (4 tablets in the morning and 3 tablets at lunchtime). The effectiveness of the therapy was evaluated based on the primary combined endpoint of the study, which included progression of the disease to an extremely severe form or the occurrence of pulmonary and extrapulmonary complications that required transfer to the intensive care unit, or death of the patient during the followup period. The secondary combined endpoint of the study was resolution of clinical symptoms of the disease or achievement of reference values of laboratory and instrumental indicators.Results. No lethal outcomes were observed in the compared groups, there were no cases of development of an extremely severe course, complications requiring transfer to the intensive care unit in the main group.Conclusion. Early use of small doses methylprednisolone of in comprehensive therapy of patients with moderate and severe COVID-19 pneumonia reduces the incidence of life-threatening complications and improves the outcomes of the disease.