bluuebunny/crossref_metadata_2025_split huggingface dataset:
HPV-16 Detection and Quantitation in Whole Mouth Fluid of Oral and Cervical Cancer Patients
Authors: Divya Bose , Rao Uma Devi K. , Thavarajah Rooban , Joshua Elizabeth , Ranganathan Kannan 
Published: August 2021

Introduction:
The association of human papillomavirus (HPV) in cervical and oropharyngeal cancer is well established. There is a growing evidence that HPV could possibly contribute to oral cancer along with alcohol and tobacco use. The aim of this study was to evaluate and quantify HPV-16 in the whole mouth fluid of patients with oral squamous cell carcinoma (OSCC), cervical cancer, and normal controls.

Materials and Methods:
The whole mouth fluid of 20 patients with OSCC (Group I), 10 with cervical cancer (Group II), and 10 normal individuals (Group III) was collected by the spit technique. The DNA was extracted and quantified by quantitative polymerase chain reaction. Data were analyzed by SPSS 21 (IBM Corp. Released 2012, Armonk, NY: IBM Corp) software and analysis of variance test was used.

Results:
The mean age of Group I patients was 50.9 ± 13.5 years, Group II was 51.6 ± 8.07 years, and Group III was 46 ± 8.5 years. In Group I, 15 were males and 5 were females. In Group III, 5 were males and 5 were females. Eight patients belonging to Group I, four of Group II, and seven of Group III had HPV-16 in their whole mouth fluid.

Conclusion:
HPV-16 was identified in the whole mouth fluid of OSCC, patients with cervical cancer, and even in normal controls. However, the mean viral loads were highest in patients with cervical cancer followed by patients with OSCC and normal controls.
Oral Manifestations of COVID-19 Patients
Authors: Karthika P.S. , Rathy R. , Jayanthi P. , Harish R. K. , Ameena M. , Krishnasree R.J. 
Published: August 2021

Introduction:
The emergence of coronavirus disease 2019 (COVID-19) crisis has evoked an exigent need to explicate the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and oral mucosal lesions. The present systematic review aims to elucidate the recent literature on oral manifestations related to COVID-19 so as to help the dental professionals for better screening and early diagnosis of the disease.

Materials and Methods:
A comprehensive literature search on PubMed, Science direct, Scopus, and Embase databases was carried out from December 2019 to March 2021 using keywords “Coronavirus,” “COVID-19,” “SARSCoV-2,” “Oral mucosal lesions,” and “Oral manifestation.” Additional information was obtained from Cochrane, World Health Organization, and Medscape. The full text articles of case reports and cross-sectional studies were analyzed and included. The review included 25 articles.

Results:
Four most common oral manifestations were found: gustatory and olfactory dysfunction, xerostomia, oral mucosal lesions, and salivary gland diseases. Vasculitis, opportunistic infections, drug eruption secondary to administration of Non-Steroidal Anti-inflammatory Drugs (NSAIDs), stress, immunosuppression, and hyperinflammatory immune response secondary to COVID-19 might be some of the relevant predisposing factors responsible for the onset of oral manifestations in patients with COVID-19.

Conclusion:
The early detection of oral symptoms of SARS-CoV-2 infection could help the clinicians to perform a better screening, and in recognizing early manifestations of the disease. However, the oral manifestations might be misdiagnosed due to subsequent challenge of undergoing oral examinations, hence diverse studies should be undertaken by the researchers to gain a better insight into the topic.
Mental health outcomes among health-care workers dealing with COVID-19/severe acute respiratory syndrome coronavirus 2 pandemic
Authors: Dutta Abhijit , Sharma Avinash , Torres-Castro Rodrigo , Pachori Hariom , Mishra SukhDev 
Published: August 2021

Introduction:
The psychological impact of COVID-19 on health-care workers (HCWs) has received attention from researchers to understand the extent of the effects of the ongoing pandemic on this population. The aim of this systematic review and meta-analysis was to synthesize the currently available literature on the topic to determine the prevalence of mental health problems in HCWs.

Materials and Methods:
We conducted a systematic review and meta-analysis, searching PubMed, PsycINFO, Scopus, and Cochrane Library databases for articles published from December 2019 to August 15, 2020. We identified studies reporting the prevalence of any mental health condition in HCWs involved directly or indirectly in providing services during the COVID-19 pandemic. The prevalence proportion for individual outcome was extracted as an estimate of interest. We performed random-effects meta-analyses evaluated using Q statistic, I
2 statistic, subgroup analyses, and sensitivity analyses and assessed study quality. This review was done in adherence to the Reporting Items for Systematic Reviews and Meta-Analysis and Meta-analysis of Observational Studies in Epidemiology guidelines. The study protocol was registered prospectively at PROSPERO (CRD42020182005).

Results:
We identified 1958 studies, of which 33 studies including 39703 participants (with a median = 393; range = 88–14825) were finally included for analysis. The estimated overall prevalence were as follows: depression 32.4% (95% confidence interval [CI]: 25.9–39.3, I
2 = 99%), anxiety 32.5% (95% CI: 26.4–39.0, I
2 = 99%), insomnia or sleep disturbance 36.6% (95% CI: 36.6–48.3, I
2 = 99%), and stress 37.7% (95% CI: 24.0–52.3, I
2 = 100%).

Conclusion:
HCWs who are dealing with the COVID-19 pandemic have a significant prevalence of depression, anxiety, insomnia and poor sleep quality, and stress. The health-care workforce needs to practice self-care now more than ever, while health-care managers and policymakers need to factor in the mental health consequences of COVID-19 on their workforce.
Sexual dysfunction in clinically stable patients with bipolar disorder receiving valproate
Authors: Grover Sandeep , Mehdi Abbas , Kumar Ajay , Chakrabarti Subho , Avasthi Ajit 
Published: August 2021

Aim:
This study evaluated the prevalence of sexual dysfunction in patients with bipolar disorder, while receiving valproate monotherapy.

Materials and Methods:
Sixty-three clinically stable patients with bipolar disorder were evaluated on the Arizona sexual experience scale (ASEX), Udvalg for Kliniske Undersogelser (UKU) other side effect subscale and brief adherence rating scale.

Results:
The mean age of the study sample was 38.84 (standard deviation: 12.49) years. About three-fourth of the participants were male (76.2%). About one-fourth (28.6%) were found to have sexual dysfunction as per the ASEX. In terms of dysfunction in specific domain of sexual functioning, depending on the cut-off used, problem with sexual desire varied from 13.33% to 35.41% among males and 6.66%–46.66% in females. Erectile dysfunction was seen in 13.33%–31.25% of males and difficulty in vaginal lubrication was reported by 13.33%–26.66% of females. When those with and without sexual dysfunction as per the ASEX were compared, it was seen that those with sexual dysfunction had significantly longer duration of illness, higher prevalence of abnormal blood pressure and higher mean scores on the UKU other side effect subscale. Both the groups did not differ on other clinical variables.

Conclusion:
A significant proportion of patients receiving valproate experience sexual dysfunction. Higher prevalence of sexual dysfunction was associated with longer duration of illness, higher prevalence of abnormal blood pressure, and higher mean scores on UKU other side effect subscale.
A study of thyroid profile in patients suffering from the first episode of mania
Authors: Goyal Manish Kumar , Yadav Kuldeep Singh , Solanki Ram Kumar 
Published: August 2021

Background:
Thyroid function is commonly considered in the assessment of mood disorders. Reports of thyroid dysregulation in patients with mania are associated with several confounding factors. To eliminate confounding factors, studies of first-episode mania are desirable. This study tried to find out any relationship between thyroid disorders and mania.

Aim:
The aim of this study is to assess and compare the thyroid profile between first-episode mania and healthy controls and to ascertain the correlation between severity and duration of the manic episode with FT3, FT4, and thyroid-stimulating hormone (TSH) levels.

Materials and Methods:
This was a cross-sectional study conducted in the psychiatry department of a tertiary care hospital. Forty consecutive drug-naïve patients with first-episode mania, diagnosed according to the International Classification of Disease-10 (study group), were matched with 40 healthy controls (control group). Both the groups were compared on the basis of thyroid profile and thyroid levels were correlated with duration and severity of illness in the study group.

Results:
Nearly 7.5% of cases in the study group had hyperthyroidism, whereas 5% had subclinical hyperthyroidism. In contrast, normal controls showed 5% and 10% prevalence of hypothyroidism and subclinical hypothyroidism, respectively. A statistically significant lower level of TSH was observed in the study group (P < 0.001), whereas the mean serum levels of FT3 and FT4 were higher in the study group, but the difference was statistically nonsignificant. No significant correlation of thyroid hormones level with duration and severity of illness was noted.

Conclusion:
Our findings highlight a higher prevalence of hyperthyroidism in patients with mania and suggest the role of thyroid hormones in mania.
Relapse in opioid dependence
Authors: Sureshkumar Kailash , Dalal Pranab Kumar , Kailash Shabeeba Z. , Rudhran Vidyendaran 
Published: August 2021

Background:
Although our understanding about neurobiology of opioid dependence and availability of pharmacological treatment has gone a long way in the last few decades, psychosocial interventions play a pivotal role in the prevention of relapse owing to reasons such as less treatment-seeking behavior and poor penetrance of opioid substitution treatment. There are many studies assessing psychosocial factors in alcohol and nicotine dependence, yet the availability of such studies for opioid dependence is sparse. This study aimed at evaluating the association of relapse in opioid dependence with various psychosocial factors.

Materials and Methods:
This was a cross-sectional study with two groups of opioid dependence patients: In abstinence (N = 28) and relapse (N = 33). Psychosocial variables such as high-risk situations, coping behavior, stressful life events, self-efficacy, and social support were assessed in the two groups and analyzed for the association with opioid relapse.

Results:
This study reports that more high risk situations (odds ratio [OR] =1.58; 95% confidence interval [CI] =1.22–2.03; P = 0.017), especially negative mood state and undesirable stressful life events (OR = 2.08; 95% CI = 1.28–3.37; P = 0.05) were significantly associated with higher odds of relapse in patients of opioid dependence. Further, higher self-efficacy (OR = 0.92; 95% CI = 0.87–0.96; P = 0.017) was significantly associated with lower odds of relapse.

Conclusion:
Psychosocial factors such as high risk situations, undesirable stressful life events, and self-efficacy were significantly associated with relapse in opioid dependence. Hence, practice of a holistic, multimodal, and individualized treatment plan addressing these factors might help in reducing the relapse rates in them.
Predictors of retention in the treatment for opioid dependence
Authors: Shouan Anish , Ghosh Abhishek , Singh Shubh Mohan , Basu Debasish , Mattoo Surendra Kumar 
Published: August 2021

Background:
Literature on a longitudinal study of the determinants of treatment retention for patients with opioid dependence is limited.

Aim:
To find out patient- and treatment-related (buprenorphine-naloxone-assisted treatment [BNX treatment] versus naltrexone treatment) predictors for retention in maintenance treatment.

Materials and Methods:
A total of 100 participants with opioid dependence were recruited by convenience sampling. The primary outcome was treatment retention – 3 months and 6 months postentry into maintenance treatment. Multiple assessments were done for the severity of opioid dependence and withdrawal, high-risk behavior, quality of life, and recovery capital – baseline and 3 and 6 months. The secondary outcome was to assess the change observed in the above-listed variables.

Results and Conclusions:
Bivariate analysis across retained and the dropout groups brought out significant differences for some (type of opioids and route of administration) but not for other (age, employment, and education) patient-related factors. Multivariate analysis, adjusting for the type of maintenance treatment, rendered these associations statistically insignificant. BNX-based treatment (compared to naltrexone maintenance) was the most significant predictor of treatment retention both at the end of 3 months and 6 months. Even after controlling for the severity of opioid dependence and withdrawal, type and route of opioid use, and high-risk behavior, patients on BNX were eleven times (14 times at the end of 6 months) more likely to be retained in the treatment. BNX group had significant improvements in the domains of recovery capital, quality of life, addiction severity, and severity of opioid dependence. There is a need to scale up the BNX-assisted treatment program in India and elsewhere.
A systematic review of Indian studies on sexual dysfunction in patients with substance use disorders
Authors: Sarkar Siddharth , Chawla Nishtha , Tom Ashlyn , Pandit Prabhat Mani , Sen Mahadev Singh 
Published: August 2021

Background and Aims:
Sexual dysfunction is often associated with substance use disorders. This study aimed to synthesize Indian literature on sexual dysfunction among patients with substance use disorders.

Materials and Methods:
Electronic search engines were used to identify studies of the last 20 years that reported sexual dysfunction with different substance use disorders. Information was extracted using a predefined template. Quality appraisal of the included studies was carried out using Joanna Briggs Institute checklist.

Results:
Twenty-seven relevant papers were identified that pertained to 24 distinct studies. Most of them were in patients with alcohol dependence, and fewer were in patients with opioid dependence. The study designs were primarily single-group cross-sectional, though many case–control, cross-sectional studies were also identified. The proportion of participants with sexual dysfunction ranged from 22.2% to 76% for studies related to alcohol dependence and 40% to 90% for studies pertaining to opioid dependence. Varied types of sexual dysfunctions were identified, including poor satisfaction, lack of desire, premature ejaculation, and erectile dysfunction. Efforts to address bias and confounders were not reported in most studies.

Conclusion:
Sexual dysfunction affects a substantial proportion of patients with substance use disorders. Clinicians can make an effort to ascertain and address sexual dysfunction in their routine clinical practice while dealing with patients with substance use disorders.
Implementasi Puasa menurut Yesaya 58:1-12 di Wadah Wanita Ester GPdI Ekklesia, Jember
Authors: Sitanggang Murni Hermawaty , Laia Asatinus 
Published: August 2021

Since Old Testament times, fasting has been a part of the lifestyle of the Israelites, not least in Isaiah 58. However, this chapter does not contain instructions for implementation but God's stern rebuke of the Israelites' practice of fasting at that time. The Israelites at that time had the mistaken notion that piety only needed to be maintained during fasting and did not involve daily life. They ignored the true meaning of fasting. Therefore, in this paper, the author investigates fasting according to Isaiah 58:1-12 in everyday life. The research was conducted through a qualitative method with a descriptive approach by involving the active fasting participants from the forum of Esther GPdI Ekklesia Women. Data were collected through observation and interviews, which then resulted in the finding that participants had understood that the nature of fasting is not only about piety but also caring for others. They have fulfilled this in their daily life by praying, refraining from oppression, and being just. AbstrakSejak masa Perjanjian Lama, puasa telah menjadi bagian dari gaya hidup umat Israel, tidak terkecuali dalam Yesaya 58. Akan tetapi, pasal ini bukanlah berisi petunjuk pelaksanaan melainkan teguran keras Tuhan terhadap praktik puasa bangsa Israel saat itu. Bangsa Israel saat itu memiliki anggapan keliru bahwa kesalehan hanya perlu dipertahankan saat puasa dan tidak menyangkut kehidupan sehari-hari. Mereka abai akan makna puasa yang sesungguhnya. Oleh sebab itu, dalam tulisan ini penulis menyelidiki bagaimana imple-mentasi puasa menurut Yesaya 58:1-12 tersebut di dalam kehidupan sehari-hari. Penelitian dilakukan melalui metode kualitatif dengan pendekatan deskriptif dengan melibatkan parti-sipan yang aktif berpuasa dari Wadah Wanita Ester GPdI Ekklesia. Data dikumpulkan melalui observasi dan wawancara yang kemudian menghasilkan temuan bahwa partisipan telah memahami bahwa hakikat puasa bukan hanya soal kesalehan melainkan juga mempedulikan sesama. Mereka telah memenuhi hal ini dalam kehidupan sehari-hari dengan cara berdoa, tidak melakukan penindasan, dan bersikap adil.
LA FINANCIACIÓN DE LOS MUNICIPIOS VASCOS A TRAVÉS DE SU PARTICIPACIÓN EN LA RECAUDACIÓN POR TRIBUTOS CONCERTADOS.UNA CUESTIÓN COMPETENCIAL NO RESUELTA
Authors: ENDEMAÑO AROSTEGUI JOSÉ MARÍA 
Published: August 2021

El Estatuto de Autonomía para el País Vasco y el Concierto Económico
actualmente vigente no determinan si la competencia para regular el régimen
jurídico de la participación de los municipios vascos en la recaudación por
tributos concertados corresponde a los órganos forales de los territorios históricos
o a las comunes de la Comunidad Autónoma. La Ley de Territorios Históricos
(LTH) la atribuye a aquéllos. El legislador autonómico es competente para modificar
la LTH y, con ello, el régimen competencial actual, en el ejercicio de sus competencias
normativas, siempre que respete la imagen históricamente reconocible
de los órganos forales, como titulares de un sustrato básico de facultades implícito
al régimen de concierto económico, de acuerdo con las disposiciones adicionales
primera de la Constitución y tercera del Concierto Económico vigente.
Euskal Herriko Autonomia Estatutuak eta indarrean dagoen Kontzertu
Ekonomikoak ez dute zehazten lurralde historikoetako foru-erakundeei edota
autonomia-erkidegoko organo komunei dagokien euskal udalerriek kontzertatutako
zergen bilketan duten partaidetzaren araubide juridikoa erregulatzeko eskumena.
Lurralde Historikoen Legeak (LHL) foru-erakundeei esleitzen die ahalmen
hori. Legegile autonomikoak LHL aldatzeko eskumena du, eta, beraz, egungo eskumen-
erregimena ere alda dezake, baldin eta Kontzertu Ekonomikoaren erregimenak
inplizituki dituen oinarrizko ahalmenen titular gisa foru-erakundeek historikoki
izan duten figura errespetatzen badu, Konstituzioaren lehen xedapen gehigarriaren
eta indarrean dagoen Kontzertu Ekonomikoaren hirugarren xedapen gehigarriaren
arabera.
The Autonomous Statute of the Basque Country and the Economic
Concert currently in force do not establish whether the competence to regulate the
legal regime of the participation of the Basque municipalities in tax collection of
harmonized taxes belongs to the foral bodies of the Historical Territories or to the
common ones of the Autonomous Community. The Act for Historical Territories
assigns it to the formers. The autonomic legislator has the power to modify the Act
for Historical Territories and therefore the current allocation of powers, by means
of the exercise of its normative competences whenever it respects the historically
recognizable image of the foral bodies as holders of a basic background which
is inherent to the Economic Concert regime in conformity with the first and third
additional provisions of the Constitution and the third one of the current Economic
Concert.
LA ACTIVIDAD DE COMERCIALIZACIÓN EN LA LEY 24/2013, DE 26 DE DICIEMBRE, DEL SECTOR ELÉCTRICO
Authors: ESTOA PÉREZ ABEL 
Published: August 2021

La Ley 24/2013, de 26 de diciembre, del sector eléctrico, regula un
nuevo modo de suministro, e introduce novedades en la actividad de comercialización.
Sobre esto último destacan las obligaciones exigibles a las empresas de comercialización.
En particular, la Ley 24/2013 aclara que el comercializador deberá
abonar al distribuidor los peajes devengados por el ejercicio de su actividad, incluso
en caso de impago del consumidor, cliente final, bajo amenaza de sanción al comercializador.
También son relevantes las nuevas obligaciones sobre protección del consumidor
que recaen sobre el comercializador. Entre los derechos de los consumidores
figura la posibilidad de someter controversias entre los clientes finales personas
físicas y los operadores al Ministerio de Industria, Energía y Turismo (MINETUR).
Sektore elektrikoari buruzko abenduaren 26ko 24/2013 Legeak
hornikuntza-modu berri bat arautu du, eta hainbat berritasun sartu ditu elektrizitatea
merkaturatzeko jardueran. Azken horien artean, nabarmentzekoak dira merkaturatze-
enpresei ezarritako obligazioak. Zehazki, 24/2013 Legeak argitzen du merkaturatzaileak
jarduera gauzatzeagatik sortutako bidesariak ordaindu beharko dizkiola
banatzaileari, bai eta azken bezero den kontsumitzaileak ordaindu ez duenean ere,
bestela zehapena jarriko baitzaio. Aipatzekoak dira, halaber, kontsumitzailea babesteko
merkaturatzaileak izango dituen obligazio berriak. Kontsumitzaileak, besteak
beste, eskubidea izango du pertsona fisiko diren azken bezeroen eta operadoreen
arteko gatazkak Industria, Energia eta Turismo Ministerioari jakinarazteko.
The Law 24/2013, of 26 December 2013, regarding the electricity
sector, establishes a new system of supply, and a new regime for the suppliers.
With regard to the latter, new obligations to suppliers must be highlighted. The Law
24/2013 establishes that the supplier must pay to the distributor the corresponding
tariffs even if the final costumer has failed to pay the bill, with the menace of an
administrative sanction to be imposed to the supplier. New obligations regarding
costumer protection are also very relevant. Among the new rights regarding
costumer protection we must point out the action before the Ministry of Industry,
Energy and Tourism (MINETUR), in case of dispute with the operator.
PARTIDOS POLÍTICOS Y GRUPOS MUNICIPALES: UN DEBATE NO CERRADO SOBRE SUS RELACIONES JURÍDICAS
Authors: LASAGABASTER HERRARTE IÑAKI 
Published: August 2021

En el trabajo se analiza la sentencia del Tribunal Constitucional
10/2013, que confirma la dictada por el Tribunal Supremo, precisando que el Alto
órgano constitucional desconoce su jurisprudencia, ya consolidada, sobre la diferenciación
entre partidos políticos y grupos municipales. La intervención de los
tribunales, sin habilitación legal, resolviendo sobre la regulación y existencia de
grupos municipales es contraria a la autonomía local.
Lan honek Konstituzio Auzitegiaren 10/2013 Epaia du aztergai.
Epai horrek Auzitegi Gorenak emandakoa berresten du, zeinaren arabera organo
konstituzional gorenak ez duen ezagutzen alderdi politikoen eta udal-taldeen arteko
aldeari buruzko jurisprudentzia, finkatuta dagoena. Auzitegiek, lege-gaikuntzarik
gabe, udal-taldeen erregulazioari eta existentziari buruzko erabakiak hartzea tokiko
autonomiaren aurkakoa da.
In this work, we analyze the Constitutional Court judgement
10/2013, which upholds the Supreme Court ruling specifying that the Higher
Constitutional body does not know its case law, already well-established, about
the distinction between political parties and municipal political groups. The
intervention of courts, without legal authorization, solving the regulation and
existence of municipal political groups is contrary to local autonomy.