bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ambulatory Orchidopexy Is a Potential Solution to Improve the Rate of Timely Repair in Cryptorchid Boys: An 8 Year Retrospective Study of 4,972 Cases
Authors: Zhao Tianxin , Deng Fuming , Jia Wei , Gao Xiaofeng , Li Zhongmin , Tang Xiangliang , Li Dian , Zhou Rui , Shu Fangpeng , Zhang Jin , Zhang Zhengtao , Fu Wen , Liu Guochang 
Published: May 2021

Background: Cryptorchidism is the most common congenital anomaly in pediatric urology. Although early surgery on cryptorchid boys is recommended by pediatric urologists worldwide, the actual age at orchidopexy is often older than the recommended age. Our medical center has started performing ambulatory orchidopexy since March 2016 at the ambulatory surgery center. We aimed to investigate whether ambulatory orchidopexy can improve the timely repair rate.Methods: A retrospective analysis was conducted from 2012 to 2019 at our medical center. Ambulatory orchidopexy was started at our medical center on March 24, 2016. Boys born on or after September 24, 2015 were classified into the “with ambulatory medical resource” group, and boys born before September 24, 2014, were classified into the “without ambulatory medical resource” group. The timely repair rates were calculated and compared.Results: A total of 4,972 cryptorchidism cases were included in the final study. Approximately 33.0% of cryptorchid boys received timely surgery (orchidopexy by the age of 18 months), and only 6.8% of all cryptorchid boys underwent surgery before the age of 1 year. After the performance of ambulatory orchidopexy, the timely repair rate increased from 25.7 to 37.0% (P &lt; 0.001), and the percentage of patients receiving surgery before the age of 1 year increased significantly from 3.5 to 8.6% (P &lt; 0.001). The proportion of timely repair in patients with ambulatory medical resources was significantly higher than that in patients without ambulatory medical resources (15.6% vs. 58.2%, P &lt; 0.001). Significant changes in the rate of surgery before 12 months of age were also found between the two groups (2.4% vs. 14.8%, P &lt; 0.001).Conclusions: After the performance of ambulatory orchidopexy in our medical center, the rates of both timely repair and receiving surgery before the age of 1 year increased significantly. Ambulatory orchidopexy is a potential solution to improve the rate of timely repair in cryptorchid boys, and it is worthy of promotion in developing countries and regions.
Dynamic Arterial Elastance Is Associated With the Vascular Waterfall in Patients Treated With Norepinephrine: An Observational Study
Authors: Bar Stéphane , Nguyen Maxime , Abou-Arab Osama , Dupont Hervé , Bouhemad Belaid , Guinot Pierre-Grégoire 
Published: May 2021

Introduction: It has been suggested that dynamic arterial elastance (Eadyn) can predict decreases in arterial pressure in response to changing norepinephrine levels. The objective of this study was to determine whether Eadyn is correlated with determinants of the vascular waterfall [critical closing pressure (CCP) and systemic arterial resistance (SARi)] in patients treated with norepinephrine.Materials and Methods: Patients treated with norepinephrine for vasoplegia following cardiac surgery were studied. Vascular and flow parameters were recorded immediately before the norepinephrine infusion and then again once hemodynamic parameters had been stable for 15 min. The primary outcomes were Eadyn and its associations with CCP and SARi. The secondary outcomes were the associations between Eadyn and vascular/flow parameters.Results: At baseline, all patients were hypotensive with Eadyn of 0.93 [0.47;1.27]. Norepinephrine increased the arterial blood pressure, cardiac index, CCP, total peripheral resistance (TPRi), arterial elastance, and ventricular elastance and decreased Eadyn [0.40 (0.30;0.60)] and SARi. Eadyn was significantly associated with arterial compliance (CA), CCP, and TPRi (p &lt; 0.05).Conclusion: In patients with vasoplegic syndrome, Eadyn was correlated with determinants of the vascular waterfall. Eadyn is an easy-to-read functional index of arterial load that can be used to assess the patient’s macro/microcirculatory status.Clinical Trial Registration:ClinicalTrials.gov #NCT03478709.
Mental Health Applications for Primary and Secondary Prevention of Common Mental Disorders: Attitudes of German Employees
Authors: Michaelis Martina , Burgess Stephanie , Junne Florian , Rothermund Eva , Gündel Harald , Zipfel Stephan , Wolf Markus , Rieger Monika A. 
Published: May 2021

Background: Web-based and mobile mental health applications for the prevention and treatment of common mental disorders (CMDs) are on the rise. Under certain circumstances they have proved to be effective for a range of conditions (e.g., depression).Objective: There is not sufficient evidence regarding the benefits and barriers especially for mobile phone apps and for programs in the field of primary prevention. Studies on the acceptance of potential users of mental health apps yielded mixed outcomes. In a large survey we investigated the attitudes of employees toward mental health apps and various traditional mental health services. Our main research question in this contribution focuses on the acceptance of apps compared to other measures and the moderating influence of individual characteristics.Methods: The standardized survey was completed by members of an online access panel with different job types. A set of 33 self-developed items, including three questions on e-health, captured the perceived relevance of prevention at the (A) occupational, (B) individual, and (C) societal level. On the basis of an exploratory factor analysis, mean scores for mapping seven (sub-)dimensions were constructed and compared using the Wilcoxon test. The influence of potential predictors was analyzed in linear regression models.Results: The data of 610 respondents were analyzed (response rate 75%). Support from mental health applications was rated significantly less important compared to all other dimensions at the levels (A) to (C). Respondents were more likely to use mental health apps if they felt literate with electronic devices, perceived a high relevance of work-related demands as causal factors for CMDs, stated they would be ashamed of having a CMD, and would be willing to begin psychotherapy if recommended.Discussion and Conclusions: The results confirm the critical attitudes of potential mental health app users found in other studies. Since users with a negative attitude toward e-health might have a higher risk for dropout and non-adherence as well as lower intervention effects, well-designed educational strategies should be carried out beforehand.
Does the Delivery System Matter? The Scaling-Out of a School-Based Resilience Curriculum to the Social Services Sector
Authors: Lilja Josefine L. , Kimber Birgitta , Eriksson Charli , Henriksson Barbro , Skoog Therése 
Published: May 2021

Background:The context is highly relevant to the implementation of new health-related programs and is an implicit or explicit part of the major implementation models in the literature. The Resilience Curriculum (RESCUR) program was developed to foster the psychosocial development of children in early and primary education. RESCUR seeks specifically to decrease children's vulnerability. It aims to promote the emotional and social learning of children who may be at risk of leaving school pre-maturely, social exclusion and mental-health problems. The program is taught using a teachers' manual to support consistency of delivery, a parents' guide, and a resource package. This study aimed to examine the scaling-out of RESCUR to social services, and specifically to test if implementation differs between the school and social services sectors.Methods:RESCUR was implemented in schools and social services in Sweden 2017–2019. Data were collectedviagroup leaders' self-reports and observation protocols for 3 months after implementation started. There were 34 self-reports from schools, and 12 from the social services sector; 30 observation protocols were collected from schools, and 10 from social services. We examined whether there were differences in implementation outcomes (in, for example, dosage, duration, fidelity, adaptation, quality of delivery) between the two delivery systems. Descriptive statistics were prepared and non-parametric tests of significance conducted to compare implementation-related factors across the two settings.Results:Analyses of both the observation protocols and group leaders' self-reports revealed that RESCUR was well-implemented in both schools and social services. The results showed a few significant differences in the outcomes of implementation between the sectors. First, regarding observations, school staff more often adapted the pace of RESCUR lessons to ensure that the children could understand than did social services staff (p &lt; 0.01). Second, social services staff demonstrated greater interest in students and sensitivity to the needs of individual students than did school staff (p = 0.02). Regarding self-reports, social services staff reported having delivered more (p = 0.4) and longer (p &lt; 0.01) lessons than did school staff. Second, school staff reported greater fidelity to (p = 0.02) and less adaptation of (p &lt; 0.01) the intervention than did social services staff. Both observations and self-reports, however, indicated a high fidelity of implementation.Conclusions:Overall, the findings suggest that the resilience program, designed for delivery in schools, can be scaled-out to social services with its implementation outcomes retained. Further research is needed to test the effectiveness of the program regarding child health-related outcomes.Clinical Trial Registration:National Institute of Health,ClinicalTrials.gov, identifier: NCT03655418. Registered August 31, 2018.
EEG-Based Measures in At-Risk Mental State and Early Stages of Schizophrenia: A Systematic Review
Authors: Perrottelli Andrea , Giordano Giulia Maria , Brando Francesco , Giuliani Luigi , Mucci Armida 
Published: May 2021

Introduction: Electrophysiological (EEG) abnormalities in subjects with schizophrenia have been largely reported. In the last decades, research has shifted to the identification of electrophysiological alterations in the prodromal and early phases of the disorder, focusing on the prediction of clinical and functional outcome. The identification of neuronal aberrations in subjects with a first episode of psychosis (FEP) and in those at ultra high-risk (UHR) or clinical high-risk (CHR) to develop a psychosis is crucial to implement adequate interventions, reduce the rate of transition to psychosis, as well as the risk of irreversible functioning impairment. The aim of the review is to provide an up-to-date synthesis of the electrophysiological findings in the at-risk mental state and early stages of schizophrenia.Methods: A systematic review of English articles using Pubmed, Scopus, and PsychINFO was undertaken in July 2020. Additional studies were identified by hand-search. Electrophysiological studies that included at least one group of FEP or subjects at risk to develop psychosis, compared to healthy controls (HCs), were considered. The heterogeneity of the studies prevented a quantitative synthesis.Results: Out of 319 records screened, 133 studies were included in a final qualitative synthesis. Included studies were mainly carried out using frequency analysis, microstates and event-related potentials. The most common findings included an increase in delta and gamma power, an impairment in sensory gating assessed through P50 and N100 and a reduction of Mismatch Negativity and P300 amplitude in at-risk mental state and early stages of schizophrenia. Progressive changes in some of these electrophysiological measures were associated with transition to psychosis and disease course. Heterogeneous data have been reported for indices evaluating synchrony, connectivity, and evoked-responses in different frequency bands.Conclusions: Multiple EEG-indices were altered during at-risk mental state and early stages of schizophrenia, supporting the hypothesis that cerebral network dysfunctions appear already before the onset of the disorder. Some of these alterations demonstrated association with transition to psychosis or poor functional outcome. However, heterogeneity in subjects' inclusion criteria, clinical measures and electrophysiological methods prevents drawing solid conclusions. Large prospective studies are needed to consolidate findings concerning electrophysiological markers of clinical and functional outcome.
Near Real-Time Processing Chain for MSG SEVIRI Data for Free and Immediate Earth Monitoring Capabilities
Authors: Sobrino José A. , Julien Yves 
Published: May 2021

Although numerous instruments are continuously observing our planet, the general public has a low access to these data, either being provided with a delay, or needing some scientific background to exploit them. Our objective here is to bridge this gap, by using the data we receive from our MSG-SEVIRI (Meteosat Second Generation—Spinning Enhanced Visible InfraRed Imager) station, by processing them to retrieve accurate characteristics of the surface, and uploading them within 5 min of image completion on a dedicated webpage, updated with every new data. For half our planet, we provide in real time a specifically designed quickook and surface temperature every 15 min, with an accuracy similar to the one achieved in previous works. We also provide every 15 min the hotspots detected using a validated approach. Once a day, we provide vegetation greenness [Normalized Difference Vegetation Index (NDVI)] for the 12:00 UTC acquisition, corresponding to the best illumination case, as well as anomalies for NDVI and surface temperature. These parameters are provided freely as full resolution images, readily understandable for the end-user, in three different languages (English, Spanish and French): https://www.uv.es/iplsat. These data, along with short time lapse videos, can be used for educational, scientific and communication purposes.
Trends in the prescription of drugs used for insomnia: an open-cohort study in Australian general practice, 2011–2018
Authors: Begum Mumtaz , Gonzalez-Chica David , Bernardo Carla , Woods Amelia , Stocks Nigel 
Published: May 2021

BackgroundDespite an increase in the prevalence of sleep problems, few studies have investigated changes in the prescribing of drugs that are often used to manage insomnia.AimTo explore changes in the pattern of benzodiazepine (BZD), Z-drug (zolpidem, zopiclone), and non-BZD prescriptions.Design and settingOpen-cohort study comprising 1 773 525 patients (55 903 294 consultations) who attended one of 404 Australian general practices at least three times in two consecutive years between 2011 and 2018.MethodData were extracted from MedicineInsight, a database of 662 general practices in Australia. Prescription rates per 1000 consultations, the proportion of repeat prescriptions above recommendations, and the proportion of prescriptions for patients with a recent (within 2 years) recorded diagnosis of insomnia were analysed using adjusted regression models.ResultsRates of BZD, Z-drug, and non-BZD prescriptions were 56.6, 4.4, and 15.5 per 1000 consultations in 2011 and 41.8, 3.5, and 21.5 per 1000 consultations in 2018, respectively. Over the whole study period, temazepam represented 25.3% of the prescriptions and diazepam 21.9%. All BZD and zolpidem prescriptions declined over the whole study period (annual change varying from −1.4% to −10.8%), but non-BZD and zopiclone prescriptions increased in the same period (annual change 5.0% to 22.6%). Repeat prescriptions that exceeded recommended levels remained at <10% for all medications, except melatonin (64.5%), zolpidem (63.3%), zopiclone (31.4%), and alprazolam (13.3%). In 2018, >50% of Z-drug and melatonin prescriptions were for patients with insomnia. There was an annual increase of 0.8–5.9% in the proportion of prescriptions associated with a recently recorded diagnosis of insomnia.ConclusionOverall, BZD prescriptions in Australia declined between 2011 and 2018. However, the prescription of some of these drugs increased for patients with a recently recorded diagnosis of insomnia. This is concerning because of the potential adverse effects of these medications and the risk of dependence.
Experiences of general practice care for self-harm: a qualitative study of young people’s perspectives
Authors: Mughal Faraz , Dikomitis Lisa , Babatunde Opeyemi O , Chew-Graham Carolyn A 
Published: May 2021

BackgroundSelf-harm is a growing concern and rates of self-harm in young people (aged 12–25 years) presenting to general practice are rising. There is, however, little evidence about young people’s experiences of GP care and on accessing general practice.AimTo explore the help-seeking behaviours, experiences of GP care, and access to general practice of young people who self-harm.Design and settingIn this qualitative study, semi-structured interviews were conducted with young people aged 16–25 years from England with previous self-harm behaviour.MethodInterviews with 13 young people took place between April and November 2019. Young people were recruited from the community, third-sector organisations, and Twitter. Data were analysed using reflexive thematic analysis with principles of constant comparison. A patient and public involvement advisory group informed recruitment strategies and supported interpretation of findings.ResultsYoung people described the avenues of help-seeking they employ and reflected on the mixed experiences of seeing GPs that can influence future help-seeking. Preconceptions and a lack of knowledge about accessing general practice were found to be barriers to help-seeking. GPs who attempt to understand the young person and establish relationship-based care can facilitate young people accessing general practice for self-harm.ConclusionIt is important young people are aware of how to access general practice and that GPs listen, understand, and proactively follow-up young people who self-harm. Supporting young people with self-harm behaviour requires continuity of care.
UJI EFEKTIFITAS DAUN PANDAN WANGI (PANDANUS AMARYLLIFOIUM ROXB) SEBAGAI ANTIJAMUR TERHADAP PITYSPORUM OVALE
Authors: Siregar Saadah , Topia Riana 
Published: May 2021

The Pandan Wangi leaf plant is a plant that belongs to the Pandanaceae family. The metabolite content of fragrant pandan leaves (Pandanus amaryllifolius Roxb.) Alkaloids, flavonoids, saponins, tannins are known to have an antifungal effect. Pityrosporum ovale is a yeast or single-celled fungus that belongs to the genus Malassezia sp, and belongs to the Cryptococcaceae family. Pityrosporum ovale causes superficial dermatomycosis which affects the stratum corneum in the epidermis layer. This fungus is a normal flora on the scalp, but in conditions of hair with excess oil glands, this fungus can thrive. The purpose of this study was to determine the inhibition zone of fragrant pandanus leaves (Pandanus amaryllifolius Roxb.) Concentrations of 10%, 20%, 30%, and 40% of Pytirosporum ovale on Potato Dextrose Agar media by diffusion method using disc paper.
The diffusion method was used to measure the diameter of the zone of inhibition against fungal growth. The positive control used was ketoconazole 2% and negative control DMSO 1%. The results of the study using the diameter of the inhibition zone at a concentration of 10% were 7.86 mm, the inhibition zone at a concentration of 20% was 8.53 mm, the inhibition zone at a concentration of 30% was 8.76 mm, and the inhibition zone at a concentration of 40% was 9, 43 mm.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN HIPEREMESIS GRAVIDARUM PADA IBU HAMIL TRIMESTER PERTAMA DI WILAYAH PUSKESMAS TANJUNG PASIR 2020
Authors: Lubis Basyariah , Hanim Latifah , Br Bangun Srimelda , Ajartha Ronny 
Published: May 2021

The incidence of hyperemesis gravidarum in Indonesia ranges from 1% to 3% of all pregnancies. Hyperemesis gravidarum can cause problems in pregnancy such as anemia, while anemia itself can result in shock due to lack of nutritional intake, all of which are eaten and drunk. This study aims to determine the relationship between adaptation and psychological factors with the incidence of hyperemesis gravidarum in pregnant women in the first trimester in the Tanjung Pasir Health Center area.
This research is an analytical survey with a cross sectional approach. The study was conducted in the Tanjung Pasir 2020 Public Health Center area from March to August 2020. The population in this study were 108 pregnant women in the first trimester at the Hamidah Clinic and a sample of 52 people. Data were obtained using a questionnaire, data analysis consisted of univariate and bivariate analysis. Bivariate analysis using the Chi Square statistical test at α = 5%.
The results showed that there was no relationship between adaftation factors (anemia and primigravida) with hyperemesis gravidarum, while psychological factors (unwanted pregnancy, work pressure, income and family harmony) had a relationship with hyperemesis gravidarum.
The conclusion of this study is there is a relationship between psychological factors and the incidence of hyperemesis gravidarum in pregnant women in the first trimester in the Tanjung Pasir Puskesmas area. It is suggested that the respondents should increase their knowledge about how to prevent and overcome hyperemesis gravidarum.
ANALISIS KEUNTUNGAN PEDAGANG DAGING KELELAWAR DI PASAR TRADISIONAL KECAMATAN AMURANG DAN KECAMATAN MODOINDING KABUPATEN MINAHASA SELATAN
Authors: Kasenda Defren Ch , Osak R E.M.F , Lumy T F.D , Oroh F N.S 
Published: May 2021

PROFIT ANALYSIS OF THE BAT BUSHMEAT TRADER IN THE TRADITIONAL MARKET IN AMURANG AND MODOINDING DISTRICKS OF SOUTH MINAHASA REGENCY. This study aims to analyze how much profit bat traders make in traditional markets in South Minahasa Regency. This research was conducted using a survey method and analyzes the level of business profit and its ability to generate profit (profitability) in bat meat dealers in traditional markets in the South Minahasa Regency. The results of this study show that the total cost of bat dealers reached an average of IDR 3.800.068. with an average acceptance of bat traders of IDR 4.898.438 per week. The total profit per bat dealer per week was IDR 849,557. with a gross margin of the traditional Amurang market of 0.13 and the traditional Modoinding market of 0.29.
TINGKAT KESUKAN JENIS MAKANAN DAN PENGARUHNYA TERHADAP PERTAMBAHAN BERAT BADAN TIKUS EKOR PUTIH (Rattus xanthurus) DI PENANGKARAN EX-SITU
Authors: Walukow Seysi R.F. , Kiroh H.J. , Wahyuni I. , Wungow R.S.H. 
Published: May 2021

THE PREFERENCE OF FOOD TYPE AND THE INFLUENCE ON WEIGHT GAIN OF WHITE TAILED RAT (Rattus xanthurus) IN EX-SITU BREEDING. White tailed rats (Rattus xanthurus) is one of the endemic species of North Sulawesi that has the status of near threatened. The method used in this study is the method of observation. This research was conducted to provide information about the most preferred type of food and its effect on body weight gain, food consumption and the efficient use of white rat (Rattus xanthurus) so that they can be utilized in animal breeding business. The results showed that the type of food most preferred by the White Tailed Rat (Rattus xanthurus) female was papaya fruit 55.62 gr / head / day while males preferred the banana 49.28 gr / head / day. Weight gain in males is higher 17.79 g / head / day compared to females 10.09 g / head / day lower with 60 gr / head / day feeding. The highest efficiency of food use is found in males, this condition can be interpreted that the amount of consumption is enough to contribute to the weight gain of white tailed rats (Rattus xanthurus). The results of this study it can be concluded that the white tailed rat (Rattus xanthurus) prefers papaya fruit compared to other fresh foods.Keywords: Preference, Weight gain, White-tailed rat