bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of EQ-5D-5L as a routine outcome measure in Community Outpatient and Specialized Rehabilitation Services
Authors: Churchill Katie , Warner Lisa , Keogh Eileen , Al Sayah Fatima 
Published: October 2021

AbstractRehabilitation is a person-centred approach that optimizes functioning to reduce impairments in individuals with illness, injury or disability. Patient-reported outcome measures (PROMs) have a role in rehabilitation to inform clinical practice, enhance patient-centered care, support health services programming, direct performance measurement, and contribute to quality improvement. A Canadian provincial health system implemented a Rehabilitation Model of Care that provides a real-world perspective on the adoption of a standardized PROM, the EuroQol EQ-5D-5L, in the community rehabilitation setting. This article will provide an overview of PROMs implementation in the community rehabilitation context, and discuss key facilitators and challenges to implementation within the 18 early adopter sites and with the spread and scale to 152 urban and rural sites. A change management approach, contextualized local coaching and strong leadership support were facilitators in the initial phases of implementation. Adequate resources and infrastructure from technological platforms for electronic data capture and visualization were assets in addition to clinical teams that had existing strong quality improvement cultures to collect PROMS in existing workflows. Challenges to implementation include the clinical relevance of the PROM, difficulty with contextualization to suit diverse clinical and programmatic teams, and the need for further knowledge sharing activities to build readiness for adoption. The implementation of PROMs in community rehabilitation has added value at the clinical (micro), programmatic (meso) and health system level (macro). Clinically, it has promoted the importance of incorporating the patients’ voice into outcome measurement. At the program level, the cultivation of a data informed learning community was fostered as teams make improvements and use data to inform future program growth or service changes. Finally, at the health system level, data visualization promotes transparency and accountability with performance across the province and the standardized use of the EQ-5D-5L provides a consistent language to promote measurement throughout the health system.
Automated detection of colon cancer using genomic signal processing
Authors: Naeem Safaa M. , Mabrouk Mai S. , Eldosoky Mohamed A. , Sayed Ahmed Y. 
Published: October 2021

AbstractBackgroundDisorders in deoxyribonucleic acid (DNA) mutations are the common cause of colon cancer. Detection of these mutations is the first step in colon cancer diagnosis. Differentiation among normal and cancerous colon gene sequences is a method used for mutation identification. Early detection of this type of disease can avoid complications that can lead to death. In this study, 55 healthy and 55 cancerous genes for colon cells obtained from the national center for biotechnology information GenBank are used. After applying the electron–ion interaction pseudopotential (EIIP) numbering representation method for the sequences, single-level discrete wavelet transform (DWT) is applied using Haar wavelet. Then, some statistical features are obtained from the wavelet domain. These features are mean, variance, standard deviation, autocorrelation, entropy, skewness, and kurtosis. The resulting values are applied to the k-nearest neighbor (KNN) and support vector machine (SVM) algorithms to obtainsatisfactoryclassification results.ResultsFour important parameters are calculated to evaluate the performance of the classifiers. Accuracy (ACC), F1 score, and Matthews correlation coefficient (MCC) are 95%, 94.74%, and 0.9045%, respectively, for SVM and 97.5%, 97.44%, and 0.9512%, respectively, for KNN.ConclusionThis study has created a novel successful system for colorectal cancer classification and detection with the well-satisfied results. The K-nearest network results are the best with low error for the generated classification system, even though the results of the SVM network are acceptable.
A very rare case report of bilateral maldescended ovaries and müllerian duct anomaly associated with inflammatory myositis, myasthenia gravis and thymic pathology
Authors: Rakhshankhah Nima , Ebrahimi Ramin , Ataee Kachuee Manizhe , Mohammadi-Vajari Mohammad-Ali , Abouie Abolfazl 
Published: October 2021

Abstract
Background
Maldescended ovaries are a rare condition. Despite its different embryologic development with the uterus, maldescended ovary is usually accompanied by uterine malformations and is found during the course of infertility. In other cases, it may be incidentally diagnosed in examinations due to abdominal pain or in a survey of finding paraneoplastic origin. Probable immune-related developmental conditions are associated with this abnormality; sometimes cross-reaction with other immune-related diseases is possible.

Case presentation
Here, the probable paraneoplastic origin is surveyed for a patient with coexisting inflammatory myositis and myasthenia gravis. According to this survey non recognized Mullerian duct and ovarian anomalies were found.

Conclusions
Knowledge about this anatomical abnormality is helpful for clinicians to prevent misdiagnosis and improper management. Moreover, understanding the probability of accompanying other conditions such as immune-related and neuromuscular junction disorders with Mullerian duct anomalies can offer a comprehensive insight.
Is psychosis a syndemic manifestation of historical and contemporary adversity? Findings from UK Biobank
Authors: Bhui Kamaldeep , Halvorsrud Kristoffer , Mooney Roisin , Hosang Georgina M. 
Published: October 2021

BackgroundPsychosis is associated with many forms of adversity, deprivation and living in urban areas.AimsTo investigate whether psychosis is part of a syndemic of multiple adversities.MethodDrawing on UK Biobank (UKBB) data (Project ID: 57601), we sought to understand mechanisms by which childhood, recent/contemporary and place-based adversities might cluster and interact to be implicated in pathways by which psychoses evolve. We investigated the associations between adversities, potential mediating inflammatory markers and ICD-10 diagnoses (F20–F31) of psychotic disorders. We fitted logistic regression models initially including all relevant candidate variables and used backwards deletion to retain theoretically plausible and statistically significant (P < 0.05) associations with psychotic disorders. The candidate variables were entered in a partial least squares structural equation model (PLS-SEM) to test for syndemic interactions between risk factors. We tested whether the findings were sensitive to demographics, gender and ethnicity.ResultsWe fitted a PLS-SEM including psychosis as a syndemic outcome, and identified three latent constructs: lifetime adversity, current adversity and biomarkers. Factor loadings were above 0.30, and all structural paths were significant (P < 0.05). There were moderate associations between lifetime adversity and current adversity (standardised coefficient s.c. = 0.178) and between current adversity and biomarkers (s.c. = 0.227). All three latent constructs showed small but significant associations with psychosis (s.c. < 0.04). Lifetime adversity and current adversity were more strongly associated among ethnic minorities (combined) than White British people.ConclusionsOur findings stress the importance of interactions between childhood and contemporary adversities in preventive and therapeutic interventions for psychotic disorders, especially among ethnic minorities.
Spontaneity of nuclear fusion: a qualitative analysis via classical thermodynamics
Authors: Tosti Silvano 
Published: October 2021

Background: So far the feasibility of nuclear reactions has been studied only through the evaluation of the reaction rate, which gives us information about the kinetics, while the thermodynamic analysis has been limited to evaluations of the change in enthalpy without any consideration of the change in entropy. Methods: This work examines the thermodynamics of nuclear fusion reactions through a simplified approach. The analysis introduces the thermodynamic study of fission and fusion reactions through their comparison with a chemical process. Results: The main result is that fission reactions are always spontaneous (ΔG < 0) since a lot of energy is released in the form of heat and the system moves spontaneously towards a more disordered state. In contrast, fusion reactions are spontaneous only when the enthalpic contribution of the change in Gibbs energy overcomes the entropic contribution. This condition is verified when the temperature of the process is below a characteristic value T*, calculated as the ratio between the energy corresponding to the mass defect and the change of entropy of the fusion reaction. Conclusions: Due to the unavailability of data related to entropy changes in fusion reactions, only a qualitative thermodynamic analysis has been carried out. Through such analysis, the influence of the operating conditions over the spontaneity of fusion processes has been discussed. The final considerations emphasize the role of the thermodynamics analysis that should be implemented in the current studies that, so far, have been mainly based on the assessment of the reaction rate and exothermicity of fusion reactions.
The role of intermittent PTH administration in conjunction with allogenic stem cell treatment to stimulate fracture healing
Authors: Osagie-Clouard Liza , Meeson Richard , Sanghani-Kerai Anita , Bostrom Mathias , Briggs Timothy , Blunn Gorden 
Published: October 2021

Aims A growing number of fractures progress to delayed or nonunion, causing significant morbidity and socioeconomic impact. Localized delivery of stem cells and subcutaneous parathyroid hormone (PTH) has been shown individually to accelerate bony regeneration. This study aimed to combine the therapies with the aim of upregulating fracture healing. Methods A 1.5 mm femoral osteotomy (delayed union model) was created in 48 female juvenile Wistar rats, aged six to nine months, and stabilized using an external fixator. At day 0, animals were treated with intrafracture injections of 1 × 106 cells/kg bone marrow mesenchymal stem cells (MSCs) suspended in fibrin, daily subcutaneous injections of high (100 μg/kg) or low (25 μg/kg) dose PTH 1-34, or a combination of PTH and MSCs. A group with an empty gap served as a control. Five weeks post-surgery, the femur was excised for radiological, histomorphometric, micro-CT, and mechanical analysis. Results Combination therapy treatment led to increased callus formation compared to controls. In the high-dose combination group there was significantly greater mineralized tissue volume and trabecular parameters compared to controls (p = 0.039). This translated to significantly improved stiffness (and ultimate load to failure (p = 0.049). The high-dose combination therapy group had the most significant improvement in mean modified Radiographic Union Score for Tibia fractures (RUST) compared to controls (13.8 (SD 1.3) vs 5.8 (SD 0.5)). All groups demonstrated significant increases in the radiological scores – RUST and Allen score – histologically compared to controls. Conclusion We demonstrate the beneficial effect of localized MSC injections on fracture healing combined with low- or high-dose teriparatide, with efficacy dependent on PTH dose. Cite this article: Bone Joint Res 2021;10(10):659–667.
Evaluating laboratory screening tests for malaria on blood donors candidates to reduce the risk of transfusion-transmitted malaria in an endemic area of Indonesia
Authors: Nethasia Louhenapessy  , Ria Syafitri Evi Gantini  , Susan Rahayu  , Elisabeth Lilipory  , Heri Wibowo  , Yuyun Soedarmono  , Inge Sutanto  
Published: October 2021

BACKGROUND Laboratory screening of blood donors for malaria has not been routinely performed in Indonesia. Current policy and practice simply exclude donors based on a history of active clinical malaria. This study was aimed to evaluate laboratory screening tests for malaria among blood donors in an endemic area of Indonesia.
METHODS The study was conducted on 550 consecutive blood samples withdrawn from volunteer donors at the Red Cross Blood Transfusion Unit in Ambon city using microscopic and rapid diagnostic tests for antigen as well as for antibody. Furthermore, 248 of those 550 samples were also tested for the presence of malaria DNA using 18S rRNA marker. Statistical analysis was done descriptively using SPSS software version 15 (SPSS Inc., USA).
RESULTS The overall malaria positivity rate among the donors was 4.5% (25/550). None of the specimens tested using microscopy or rapid test for malaria antigen assay were positive. However 22 (4.0%) samples were positive for malaria antibody against Plasmodium falciparum; while 3 (1.2%) were positive by PCR.
CONCLUSIONS Laboratory testing for blood donors may be used to prevent transfusiontransmitted malaria in an endemic area of Indonesia.
A cross-sectional study on the telemedicine usage and glycemic status of diabetic patients during the COVID-19 pandemic
Authors: Novi Sulistia Wati  , Pokkate Wongsasuluk  , Pradana Soewondo  
Published: October 2021

BACKGROUND The coronavirus disease 2019 (COVID-19) pandemic disrupts selfmanagement in diabetic patients in Indonesia. This study aimed to determine the telemedicine usage and factors contributing to glycemic control in type 2 diabetes mellitus (T2DM) patients during the pandemic.
METHODS A cross-sectional study was conducted in T2DM patients aged 25–54 years. The questionnaire included general characteristics, diabetes conditions, consultation factors, and self-care management. Glycemic status was evaluated using glycated hemoglobin (HbA1c) levels, which was categorized into poor (HbA1c≥7%) and good glycemic control (HbA1c<7%). Data were analyzed using chi-square and binary logistic regression.
RESULTS Of 264 patients, only 19.2% used telemedicine and 60.2% had poor glycemic control during the pandemic. Overweight or obesity (odds ratio [OR] = 5.740 [95% confidence interval [CI] = 2.554–12.899]; p<0.001), insulin injection (OR = 3.083 [95% CI = 1.238–7.677]; p = 0.016), and frequent fried food consumption (OR = 5.204 [95% CI = 1.631–16.606]; p = 0.005) were the factors contributing to poor glycemic control. The risk is lower if exercised regularly (OR = 0.036 [95% CI = 0.007–0.195]; p<0.001) and consulted with a doctor using telemedicine (OR = 0.193 [95% CI = 0.044–0.846]; p = 0.029) or in-person visits (OR = 0.065 [95% CI = 0.016–0.260]; p<0.001).
CONCLUSIONS Glycemic control was not optimal during the COVID-19 pandemic. Therefore, keeping a healthy lifestyle and staying connected with a doctor are important to ensure optimal blood glucose control and reduce the risk of diabetesrelated complications.
Analytical design of an advanced Littrow–Offner spectrometer
simultaneously off-axis in meridian and sagittal planes for ultraviolet
imaging with high performance
Authors: Wu Su , Huang Chan , Yu Lei , Xue Hui , Lin Jing 
Published: October 2021

A novel, to the best of our knowledge, configuration of a
Littrow–Offner spectrometer that is off-axis in both the meridian and
sagittal planes is proposed. Through theoretical analysis, the
relationship between the distance of each element and the aperture is
obtained, and the theoretical basis of the sagittal plane off-axis is
given. Extra aberrations are corrected by a spherical lens with a
convex grating. An example of design has been presented with an

f

-number of 4 working in 300–500 nm,
according to the theory. Its spectral resolution achieves a 0.1 nm at
central wavelength, and its volume decreases by 14.5% compared with
the traditional Offner spectrometer.
Pertumbuhan Lili (Lilium longiflorum) Pada Berbagai Komposisi Media Tanam dan Zat Pengatur Tumbuh Naphthalene Acetic Acid (NAA) pada Tahap Aklimatisasi
Authors: Maryamah Lulu Fatikhatul , Kusmiyati Florentina , Anwar Syaiful 
Published: October 2021

Zat Pengatur Tumbuh (ZPT) merupakan senyawa organik yang dapat mengatur proses fisiologi tanaman. Penelitian ini bertujuan untuk mengkaji pengaruh komposisi media dan konsentrasi NAA serta kombinasi media dan NAA terhadap pertumbuhan lili pada tahap aklimatisasi. Penelitian dilakukan di rumah plastik di kecamatan Tembalang dan Laboratorium Fisiologi dan Pemuliaan Tanaman, Fakultas Peternakan dan Pertanian Universitas Diponegoro, Semarang. Rancangan yang digunakan dalam penelitian adalah Rancangan Acak Lengkap (RAL) Faktorial 3 x 5 dengan ulangan 3 kali. Faktor pertama adalah berbagai komposisi media tanam yaitu arang sekam dan kompos, yang terdiri dari M1 (1 : 1), M2 (2 : 1) dan M3 (3 : 1). Faktor kedua adalah konsentrasi NAA terdiri dari D0 (0 ppm), D1 (2,5 ppm), D2 (5 ppm), D3 (7,5 ppm), D4 (10 ppm). Analisis data menggunakan uji anova dengan taraf signifikan 5%, jika ada perbedaan akan diuji lanjut dengan uji Duncan Multiple Range-Test (DMRT) pada taraf α = 5%. Hasil penelitian menunjukkan berbagai komposisi media menghasilkan umur bertunas, tinggi tanaman, panjang akar dan bobot segar yang berbeda nyata, tapi jumlah akar yang tidak berbeda nyata. Komposisi terbaik didapatkan pada arang sekam dan kompos pada perbandingan 3:1. Konsentrasi NAA menghasilkan umur bertunas, tinggi tanaman, jumlah daun, panjang akar dan bobot segar yang tidak berbeda nyata. Kata kunci : lili, komposisi media, konsentrasi dan NAA
Pertumbuhan Selada Merah (Lactuca sativa L. var. Red Rapid) dan Selada Hijau (Lactuca sativa L. Grand Rapids) dengan Sistem Hidroponik Apung dengan Pemberian Dosis Pupuk Organik Cair (POC) Bioslurry dan AB Mix yang Berbeda
Authors: Anwary Muhammad Nazif , Slamet W , Kusmiyati Florentina 
Published: October 2021

Tanaman selada (Lactuca sativa L.) merupakan tanaman sayuran daun yang dapat dibudidayakan dengan sistem hidroponik untuk memenuhi kebutuhan sayur pada tingkat rumah tangga. Pemberian jenis dan dosis larutan nutrisi yang tepat akan menghasilkan pertumbuhan dan hasil produksi tanaman yang baik. Penelitian ini bertujuan untuk mengkaji pengaruh pemberian pupuk organik cair (POC) bioslurry dan larutan nutrisi komersil AB mix dengan dosis yang berbeda terhadap pertumbuhan tanaman selada merah (var. Red Rapid) dan selada hijau (var. Grand Rapids) yang dibudidayakan dengan sistem hidroponik apung. Parameter penelitian adalah tinggi tanaman, jumlah daun, kadar klorofil total, kadar aktivitas nitrat reduktase (ANR), dan bobot segar tajuk tanaman. Hasil penelitian menunjukkan bahwa pemberian dosis larutan nutrisi 52,5 mL AB mix + 17,5 mL bioslurry menghasilkan rata-rata pertumbuhan dan hasil produksi tanaman yang tertinggi pada kedua kultivar tanaman selada, diikuti oleh pemberian dosis larutan nutrisi 35 mL AB mix + 17,5 mL bioslurry. Pemberian dosis larutan nutrisi 70 mL bioslurry menghasilkan rata-rata pertumbuhan dan produksi tanaman terendah pada kedua kultivar tanaman selada. Kata Kunci: AB mix, bioslurry,. hidroponik, nutrisi, selada
Respon Umur Fisiologi Bahan Stek Mawar (Rosa Sp.) pada Pemberian Konsentrasi indole-3-butyric acid (IBA) yang Berbeda
Authors: Sylviana Risty Dwi , Kristanto Budi Adi , Purbajanti Endang Dwi 
Published: October 2021

Bunga mawar memiliki nilai ekonomi tinggi dan permintaan bunga potong ataupun tanaman hias terus meningkat, maka mawar perlu dikembangkan menjadi produk unggulan agribisnis. Penelitian bertujuan untuk mengetahui bagian batang tanaman yang masih dapat digunakan sebagai bahan stek dan konsentrasi IBA yang mampu memacu pertumbuhan stek batang tanaman mawar. Penelitian menggunakan rancangan acak lengkap faktorial 3×5. Faktor pertama adalah umur bahan stek yaitu umur bahan stekmuda (10 cm dari ujung), umurbahanstek sedang (antara 20-40 cm dari ujung) dan umur bahan stek tua (40-50 cm dari ujung). Faktor kedua adalah konsentrasi IBA, yaitu 0, 25, 50, 75, dan 100 ppm. Data yang diperoleh kemudian dianalisis ragam dan dilanjutkan dengan uji Duncan's Multiple Range Test (DMRT). Hasil penelitian dapat disimpulkan bahwa bagian ujung batang atau cabang tanaman berumur muda tidak dapat digunakan sebagai bahan stek. Umur bahan stek sedang diperlukan konsentrasi IBA 50 ppm dan umur bahan stek tua diperlukan konsentrasi 75 ppm untuk dapat mempercepat proses pertumbuhan pasa stek tanaman mawar. Kata kunci : auksin, pertumbuhan, tunas
Respon Pertumbuhan dan Produksi Tomat (Solanum lycopersicum) pada Berbagai Jenis Penggunaan Mulsa dan Frekuensi Penyiraman
Authors: Mangesti Zul Aida , Budiyanto Susilo , Sutarno Sutarno 
Published: October 2021

Gunung pati merupakan daerah di kota semarang yang mempunyai curah hujan tertinggi (2400-2600 mm/tahun). Namun, hari hujan sedikit sehingga berpengaruh terhadap ketersediaan air di dalam tanah yang berakibat pada kondisi suhu dan kelembaban tanah. Tujuan dari penelitian untuk mengetahui jenis mulsa serta frekuensi penyiraman yang paling sesuai untuk pertumbuhan dan produksi tomat. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) pola faktorial 4 x 2 sebanyak 3 ulangan. Faktor Pertama terdiri dari penggunaan jenis mulsa dengan 4 jenis perlakuan,yaitu M0: tanpa mulsa, M1: mulsa jerami, M2: mulsa perak, M3: mulsa hitam. Faktor kedua terdiri dari frekuensi penyiraman dengan 2 taraf perlakuan, yaitu P1: 1 hari sekali dan P2: penyiraman 2 hari sekali. Variabel yang diamati adalah komponen pertumbuhan yang terdiri dari tinggi tanaman, jumlah daun serta produksi tanaman tomat yang terdiri dari jumlah buah, bobot buah, serta kadar air buah. Data yang diperoleh kemudian dianalisis ragam dan dilanjutkan dengan uji Duncan's Multiple Range Test (DMRT). Berdasarkan hasil penelitian dapat disimpulkan bahwa penggunaan mulsa perak frekuensi penyiraman 1 hari sekali mampu memberikan rata- rata suhu tanah terendah yaitu 29oc, memberikan rata-rata kelembaban tanah tertinggi yaitu 41,7% serta dapat memberikan hasil tertinggi pada pertumbuhan tinggi tanaman rata-rata setinggi 107,2 cm dan pada produksi tanaman memberikan rata- rata bobot buah terbesar yaitu 37,2 gr. Kata kunci : air, suhu tanah, kelembaban tanah
Naungan dan Tipe Substrat Berbeda pada Periode Aklimatisasi Ex-vitro Phalaenopsis Hibrid
Authors: Fauziah Ade Arisma , Prahasti Nurullita , Setiari Nintya , Saptiningsih Endang 
Published: October 2021

Produksi bibit Phalaenopsis Hibrid umumnya dilakukan melalui teknik kultur jaringan. Tahap selanjutnya adalah aklimatisasi plantlet di lingkungan ex-vitro. Penggunaan naungan dan tipe substrat berperan terhadap pertumbuhan dan kelangsungan hidup plantlet selama periode awal aklimatisasi. Penelitian ini mengkaji peran naungan dan tipe substrat yang berbeda terhadap pertumbuhan dan kelangsungan hidup plantlet Phalaenopsis Hibrid selama periode awal aklimatisasi di greenhouse. Penelitian menggunakan plantlet Phalaenopsis Hibrid dalam botol dan naungan paranet. Plantlet diberi 3 tipe substrat yaitu serabut kelapa, akar paku kadaka, sphagnum serta semua perlakuan dinaungi paranet secara bertahap. Parameter penelitian yang diukur meliputi: jumlah akar, total panjang akar, panjang daun, berat segar dan persentase kematian plantlet. Rancangan Acak Lengkap dengan satu faktor dan 3 ulangan digunakan dalam penelitian ini. Data dianalisis menggunakan ANOVA dan uji LSD pada taraf signifikansi 95% (P < 0,05). Penelitian dilakukan selama 5 minggu di greenhouse Jurusan Biologi, Fakultas Sains dan Matemetika, UNDIP. Plantlet tumbuh dan mampu bertahan hidup pada semua substrat dan naungan paranet secara bertahap. Pembentukan pori besar pada substrat serabut kelapa dan akar kadaka meningkatkan jumlah dan panjang akar. Kemampuan menjerap air tinggi pada spagnum meningkatkan berat segar plantlet. Penutupan paranet secara bertahap dan penggunaan substrat serabut kelapa, akar kadaka serta spagnum mempertahankan kelangsungan hidup plantlet selama periode awal aklimatisasi ex-vitro. Kata kunci:aklimatisasi, Phalaenopsis Hibrid, serabut kelapa, akar kadaka, sphagnum