bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crecimiento de terneras F1 y F2 Kiwi Cross x Holstein
Authors: Nieto-Sierra David Felipe , Timarán-Rivera Edmundo Andrés , Montes-Vergara José Carlos , Castro-Rincón Edwin , Mogollón-García Henry David 
Published: January 2021

Introducción. En el ciclo de producción de los bovinos de leche, el tiempo de crecimiento de las terneras representan un período de gastos y poco retorno para el productor, sin embargo, la preparación de hembras saludables durante este período es fundamental para incorporar al hato hembras productivas que garanticen el retorno financiero. Objetivo. Determinar los parámetros productivos y bovinométricos de las filiales uno (F1) y dos (F2) producto del cruce entre las razas de bovinos Kiwi Cross x Holstein. Materiales y métodos. Este trabajo se realizó en el Centro de Investigación Obonuco de la Corporación Colombiana de Investigación Agropecuaria (AGROSAVIA), ubicado en Pasto, Nariño, Colombia. Se utilizaron veinte hembras F1 (½ Kiwi Cross – ½ Holstein-Friesian) y veinte F2 (¾ Kiwi Cross – ¼ Holstein-Friesian). Se registraron y compararon variables productivas y bovinométricas durante el primer y sétimo mes de edad. Resultados. Las terneras F1 en el tercer mes presentaron mayor peso en comparación a las F2 (158,9±2,5 vs 115±2,5 kg, respectivamente). Ambas generaciones presentaron una disminución de ganancia diaria de peso entre el tercer y sétimo mes de edad. En el sétimo mes las terneras F1 presentaron mayores valores en comparación a las F2 en las variables perímetro de tórax (126,5±1,0 cm vs 116,9±0,9 cm), altura a la cruz (102,4±0,7 cm vs 97,0±0,7 cm), altura al anca (107,3±0,7 vs 101,2±0,7 cm), distancia entre íleon e isquion (34,5±0,4 vs 32,3±0,4 cm) y distancia entre isquiones (11,2±0,1 vs 10,2±0,1 cm). Conclusión. Entre el tercer y séptimo mes de edad se observaron las principales diferencias entre las dos filiales en la mayoría de las variables, a medida que se aumentó el porcentaje de Kiwi Cross, se obtuvieron animales de menor tamaño y peso.
STUDIES OF PHOTONUCLEAR REACTIONS AND PHOTON ACTIVATION ANALYSIS IN THE GIANT DIPOLE RESONANCE REGION USING MICROTRONS
Authors: THIEP TRAN DUC , DO NGUYEN VAN , THI NGUYEN KHAC , AN TRUONG THI , SON NGUYEN NGOC 
Published: January 2021

Mictrorons are accelerators of electrons and are simultaneous sources of bremsstrahlung
photon flux and fission neutrons. In 1982, a microtron of seventeen trajectories
Microtron MT - 17 was put into operation at the National Institute of Physics of Vietnam.
Though very modest, microtons are very useful for developing countries such as Vietnam
in both fundamental and applied physics research. During the recent years by using the
above mentioned MT - 17 and microtrons from other institutes we have carried out different
investigations. In this report we present some results obtained in the studies of photonuclear
reactions and photon activation analysis in the giant dipole resonance region.
Decrease of urinary bladder contractility in patients with benign prostate hyperplasia
Authors: Khasunovich Al-Shukri S. , Amdiy Refat E. , Kuzmin Igor V. 
Published: January 2021

Aim of the study.Estimation of the decrease of urinary bladder contractility in patients with benign prostate hyperplasia (BPH).
Patients and methods.In 146 BPH patients (mean age 62,1 0,8) urodynamic investigation including uroflowmetry and pressure-flow study was performed. The results of miction cystometry were evaluated using Shafer nomogram, the emptying idex was calculated as relation of voiding volume to maximal cystometric capacity.
Results.56,2% BPH patients showed the decreased detrusor contractility. The results of urinary bladder contractility estimation by Shafer nomogram are dependent on the degree of infravesical obstruction (IVO). The emptying index is not related to the presence and degree of IVO and characterizes the degree of urinary bladder emptying as well as contraction duration. Concomitant lumbar osteochondrosis and diabetes detoriates urinary bladder emptying. Reliable contractility estimation may only be performed based on urodynamic study since basic BPH patients examination is not sufficient.
Conclusion.In has to be considered during treatment strategy planning that in many BPH patients low urinary truct disfunction is determined by the decrease of urinary bladder contractility and not by IVO.
QUANTUM META-THEORY (Twisting the Tail of Schrödinger’s Cat)
Authors: Rescher Nicholas 
Published: January 2021

The problem of Schrödinger’s Cat has figured prominently in the debates about the bearing of quantum physics on our understanding of physical reality. On its basis, various theorists have maintained the quantum physical world exhibits a probabilistically indecisive physical reality. The analysis of the paper that this appeal to quantum reality is methodologically at odds with and disjoint from its underlying approach to quantum theory itself. If there is to be methodological uniformity at this juncture it will have to be along the lines that Einstein always focused—an incomplete hidden factor (perhaps better than “hidden variables”) approach.
Simulation and Analysis of Fluid-Solid Coupling of Wave Impact Sandcastle Based on COMSOL
Authors: Ouyang Zhen , Wang Ke , Yu Zihao , Xu Kaikai , Zhao Qianyu , Ruan Zhicheng , Zhang Yifan , Lin Wei , Sun Zheng 
Published: January 2021

It is a complex problem to study the interaction between sand castle and flowing water, which needs to consider the complexity of seawater flow and the stress of sand castle structure. The authors use the fluid-solid coupling model to establish the connection between the fluid field and the structural mechanical field, and use the finite element analysis to complete the simulation modeling of the transient process of wave impact and sandcastle foundation deformation. This paper analyzes the stress and the first principal strain of the sand castle foundation in the direction of flow velocity when the sand castle foundation is hit by waves, as a method to judge the strength of the sand castle.The best shape: the boundary value of sand castle collapse caused by strain have been determined, so as to obtain the maximum stress that a sand castle foundation can bear before collapse, which makes it possible to use the fatigue strength calculation theory of sand castle solid to carry out the quantitative calculation of sand castle durability. At the same time, the impact of waves is abstracted as wave motion equation. Finally, the finite element analysis technology is adopted to calculate the main strain of sandcastles of different shapes under the impact of the same wave, and through the comparison of the main strain, the authors get the sandcastle shape with the strongest anti-wave impact ability, which is the eccentric circular platform body.Affected by rain: the authors considered the effect of rainwater infiltration on the sandcastle's stress, and simplified the process of rain as a continuous and uniform infiltration of rain into the sandcastle's surface. The rain changes the gravity of the sand on the castle's surface. Simulation analysis is adopted to calculate the surface stress of sand castle with different degree of water seepage and different geometry. By comparison, it has been found that the smooth cone is more able to withstand the infiltration of rain without collapse.
Optimalisasi Ketebalan Timbal Untuk Mendapatkan Kualitas Citra Guna Mendukung Verifikasi Pada Pesawat Teleterapi 60Co
Authors: Maimunah Maimunah , Riyatun Riyatun , Suharyana Suharyana , Muhtarom Muhtarom 
Published: January 2021

<p class="AbstractEnglish"><strong>Abstract: </strong>The quality of radiotherapy images supports the steps of verifying the accuracy of the dose and verifying the geometry, for example the area of field and the accuracy of the patient's position. Radiotherapy image capture requires a radiation filter that is thick enough, due to the strong radiation dose from the <sup>60</sup>Co source. Lead thickness optimization is needed so that the irradiation recording on the Imaging Plate produces an adequate image to be scanned via Computed Radiography. Analysis using Dose.Lab 4.1 software with the Region of Interest technique so that the Mean Gray Value (MGV) is obtained and the contrast is obtained by the Contrast to-Noise Ratio (CNR) analysis. Standard exposure of 2 seconds and 3 seconds at the collimation area (10 x 10) cm<sup>2</sup>, using a 1,8 cm Pb filter shows the most optimal image. The thicker the Pb, the greater the MGV value, which indicates high radiation absorption. MGV will decrease with the addition of filters. The optimal thickness of Pb in decreasing the dose rate for irradiation of 1, 2 and 3 seconds, respectively, was starting from 2,7 cm and 4,5 cm, meanwhile for 3 seconds there is no optimal lead thickness.</p><p class="AbstrakIndonesia"><strong>Abstrak:</strong> Kualitas citra radioterapi mendukung tahapan verifikasi ketepatan dosis dan verifikasi geometri misalnya luas lapangan dan ketepatan posisi pasien. Pengambilan citra radioterapi memerlukan filter radiasi yang cukup tebal, disebabkan oleh kuatnya dosis radiasi dari sumber <sup>60</sup>Co. Diperlukan optimasi tebal timbal agar rekaman penyinaran pada <em>Imaging Plate </em>menghasilkan citra yang memadai untuk dipindai melalui <em>Computed Radiography</em>. Analisa menggunakan <em>Software Dose.Lab 4.1</em> dengan teknik <em>Region Of Interest</em> sehingga diperoleh <em>Mean Gray Value</em>(MGV) dan kontras diperoleh dengan analisa <em>Contrast to-Noise Ratio</em> (CNR). Eksposure standar 2 detik dan 3 detik pada luas kolimasi (10 x 10) cm<sup>2</sup>, pemakaian 1,8 cm filter Pb menunjukkan citra yang paling optimal. Semakin tebal Pb maka nilai MGV semakin besar yang menunjukkan serapan radiasi tinggi. MGV akan menurun dengan penambahan filter. Tebal Pb yang optimal dalam menurunkan laju dosis untuk penyinaran 1 dan 2 detik masing-masing adalah mulai dari 2,7 cm dan 4,5 cm, sedangkan untuk 3 detik tidak ada tebal Pb yang optimal.</p>
Like Soldiers on the Front – A Qualitative Study Understanding the Frontline Healthcare Professionals’ Experience of Treating and Caring for Patients With&nbsp;COVID-19
Authors: Dagyaran Ilkay , Risom Signe Stelling , Berg Selina Kikkenborg , Højskov Ida Elisabeth , Heiden Malin , Bernild Camilla , Christensen Signe Westh , Missel Malene 
Published: January 2021

Abstract
Background: While people in the societies must stay home to reduce spread of the newly discovered coronavirus, healthcare professionals do the exact opposite. For them the coronavirus is an enemy that should be defeated as a part of one’s job. They do, however, also have a daily life with family while doing their work obligations. The purpose of this study was to gain an in-depth understanding of the frontline healthcare professionals’ experience of balancing work life and family life during the COVID-19 pandemic.Methods: A sample of 22 frontline healthcare professionals caring for patients with COVID-19 was included and interviewed individually from May to August 2020. Ricoeur’s phenomenological hermeneutical philosophy inspired the methodology in this study. Result: Frontline healthcare professionals treating and caring for patients with COVID-19 are, voluntarily or involuntarily, forced to be ready to change departments as well as being ready to face the unknown coronavirus. The frontline work leads to feelings of being abandoned among their families and friends due to the threat of bringing the infection home and spreading the virus. Although healthcare professionals are facing a working life filled with uncertainty and unpredictability impacting their family life, they express opposing feelings of being a part of something bigger. Conclusion: The work life balance for these healthcare professionals is threatened by changes in professional responsibilities, working hours and shifts. Fear of bringing the infection home challenges them ethically and creates a distance between healthcare professionals and their families, leading to a conflict within the individual if their work on the frontline is worth it - or if it is a too high price to pay. Despite facing a working life filled with uncertainty and unpredictability the healthcare professionals are being a part of something bigger that contributes to a fighting spirit and professional pride outweighing the negative consequences; like being soldiers on the front.
BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma
Authors: Laubscher Dominik , Gryder Berkley , Sunkel Benjamin , Andresson Thorkell , Das Sudipto , Roschitzki Bernd , Wolski Witold , Wu Xiaoli , Chou Hsien-chao , Song Young , Wang Chaoyu , Wei Jun , Wang Meng , Wen Xinyu , Marques Joana , Wachtel Marco , Vakoc Christopher , Schäfer Beat , Stanton Benjamin , Khan Javed 
Published: January 2021

Abstract
Rhabdomyosarcoma (RMS) is a pediatric malignancy of skeletal muscle lineage. The aggressive alveolar subtype is characterized by t(2;13) or t(1;13) translocations encoding for PAX3- or PAX7-FOXO1 chimeric transcription factors, respectively, and are referred to as fusion positive RMS (FP-RMS). The fusion gene alters the myogenic program and maintains the proliferative state wile blocking terminal differentiation. Here we investigated the contributions of chromatin regulatory complexes to FP-RMS tumor maintenance. We define, for the first time, the mSWI/SNF repertoire in FP-RMS. We find that SMARCA4 (encoding BRG1) is overexpressed in this malignancy compared to skeletal muscle and is essential for cell proliferation. Proteomic studies suggest proximity between PAX3-FOXO1 and BAF complexes, which is further supported by genome-wide binding profiles revealing enhancer colocalization of BAF with core regulatory transcription factors. Further, mSWI/SNF complexes act as sensors of chromatin state and are recruited to sites of de novo histone acetylation. Phenotypically, interference with mSWI/SNF complex function induces transcriptional activation of the skeletal muscle differentiation program associated with MYCN enhancer invasion at myogenic target genes which is reproduced by BRG1 targeting compounds. We conclude that inhibition of BRG1 overcomes the differentiation blockade of FP-RMS cells and may provide a therapeutic strategy for this lethal childhood tumor.
One-Step Direct Oxidation of Alkoxy to Ketone for Evaporable Fullerene-Fused Ketone as Efficient Electron-Transport Materials
Authors: Lin Hao-Sheng , Ma Yue , Xiang Rong , Manzhos Sergei , Jeon Il , Maruyama Shigeo , Matsuo Yutaka 
Published: January 2021

Abstract
Ketones, one of widely applied moieties in designing electrical and medical materials, commonly converted from the alcohols through the oxidation reactions. However, when alcohols are protected/functionalized, the direct oxidation strategies are substantially curbed. Here we show a highly efficient copper bromide promoted one-step direct oxidation of alkoxy to ketone with the aid of a fullerene pendant. Mechanistic studies unveil that fullerene can serve as an electron poor proceeding the one-step oxidation of alkoxy group to ketone. In the absence of fullerene pendant, the unreachable activation energy threshold hampers the direct oxidation of alkoxy group. In the presence of fullerene pendant, copper bromide oxidized fullerene radical cation can activate neighboring C–H bond of alkoxy moieties, allowing a favorable energy barrier for initiating the direct oxidation of alkoxy group. Produced fullerene-fused ketone indicates high thermal stability, affording the pin-hole free and amorphous electron-transport layer with high electron-transport mobility.
Ferroelectric-tuned van der Waals heterojunction with band alignment evolution
Authors: Chen Yan , Wang Xudong , Huang Le , Wang Xiaoting , Jiang Wei , Wang Zhen , Wang Peng , Wu Binmin , Lin Tie , Shen Hong , Wei Zhongming , Hu Weida , Meng Xiangjian , Chu Junhao , Wang Jianlu 
Published: January 2021

Abstract
Van der Waals (vdW) integration with abundant two-dimensional materials provides a broad basis for assembling functional devices. However, band alignment in a specific vdW heterojunction (VHJ) is difficult to tune, restricting its multifunctionality and structural simplicity. Here, we designed a ferroelectric-tuned VHJ (Fe-VHJ) device structure by integrating a GeSe/MoS2 VHJ and poly (vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE))-based ferroelectric polymer. An ultrahigh electric field derived from the ferroelectric polarization that can effectively modulate the band alignment of the GeSe/MoS2 heterojunction. Band alignment transition of the heterojunction from type II to type I was demonstrated. The combination of anisotropic GeSe with MoS2 realised a high-performance polarization-sensitive photodetector exhibiting low dark current of approximately 1.5 pA, quick response of 14 μs, and high detectivity (D*) of 4.7 × 1013 Jones. Dichroism ratios were also enhanced by ferroelectric polarization in a broad-spectrum from visible to near-infrared. The GeSe/MoS2 Fe-VHJ has great potential for multifunctional detection applications in sophisticated light information sensing. More profoundly, the Fe-VHJ structure provides a valid band-engineering approach to creating versatile devices.
Mapping flows on hypergraphs
Authors: Eriksson Anton , Edler Daniel , Rojas Alexis , Rosvall Martin 
Published: January 2021

Abstract
Hypergraphs offer an explicit formalism to describe multibody interactions in complex systems. To connect dynamics and function in systems with these higher-order interactions, network scientists have generalised random walk models to hypergraphs and studied the multibody effects on flow-based centrality measures. But mapping the large-scale structure of those flows requires effective community detection methods. We derive unipartite, bipartite, and multilayer network representations of hypergraph flows and explore how they and the underlying random walk model change the number, size, depth, and overlap of identified multilevel communities. These results help researchers choose the appropriate modelling approach when mapping flows on hypergraphs.
Risk factors of sleep disturbances in elderly patients after thoracic surgery: a preliminary clinical trial
Authors: Li Bing , Liu Yao , Jia Jia , Tang Fudong , Zhang Wei , Zhang Jiaqiang 
Published: January 2021

Abstract
BackgroundTo identify the risk factors of sleep disturbances in elderly patients after thoracic surgery.MethodsWe enrolled 200 patients, all aged > 65, who underwent elective thoracic surgery and had American Society of Anesthesiology physical status II–III. We recorded general information, surgical diagnosis, type of operation, surgical duration, bleeding, nerve block, and dexmedetomidine dose given by controlled intravenous analgesia (PCIA). We used the Pittsburgh Sleep Quality Index (PSQI) at the end of PCIA to evaluate subjective sleep quality; we also recorded postoperative pain, nausea, and vomiting. We divided patients into a non-sleep disturbances group and a sleep disturbances group with PSQI \(\ge\)5 as the cutoff.ResultsA total of 76 (45%) of the patients had sleep disturbances after thoracic surgery. There were significant differences between groups in terms of chronic insomnia, hypertension, diabetes, BMI, age, surgical diagnosis, type of operation, surgical duration, bleeding, nerve block, and dexmedetomidine dose in PCIA. Logistic regression analysis revealed that chronic insomnia, BMI, diabetes, surgical diagnosis, type of operation, surgical duration, bleeding, and postoperative pain were independent risk factors of postoperative sleep disturbances. This analysis also showed that nerve block and dexmedetomidine dose in PCIA were significant protective factors of postoperative sleep disturbances.ConclusionChronic insomnia, BMI, diabetes, surgical diagnosis, type of operation, surgical duration, bleeding, and postoperative pain are independent risk factors of postoperative sleep disturbances in elderly patients. Nerve block and the dose of dexmedetomidine in PCIA are protective.Trial registrationChiCTR2000035169; retrospectively registered on 01.08.2020.
Prognostic Biomarker MUC4 Mutations in Colon Adenocarcinoma Correlating with Tumor Microenvironment
Authors: Li Ting , Hui Wenjia , Gao Feng 
Published: January 2021

Abstract
Background: Immunotherapy is a new strategy for Colorectal cancer (CRC) treatment. Tumor mutation burden (TMB) may act as an emerging biomarker for predicting responses to immunotherapy. Nevertheless, no studies investigate if these gene mutations correlate to TMB and tumor-infiltrating immune cells. Methods: Somatic mutation data for CRC samples were obtained from The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) datasets. Then, we investigated the relationship between these mutant genes, TMB and overall survival outcomes. GSEA analysis was performed to explore the underlying mechanism of mutant gene. Finally, we further verified the connection between gene mutations and immune response.Results: We identified 17 common mutant genes shared by both two cohorts. Further analysis found that MUC4 mutation was strongly related to higher TMB and predicted a poorer prognosis. Moreover, functional enrichment analysis of samples with MUC4 mutation revealed that they were involved in regulating the natural killer cell mediated cytotoxicity signaling pathway. Significant changes in the proportion of the immune cells of CD8+ T cells, activated NK cells, M1 macrophages and resting memory CD4+ T cells were observed using the CIBERSORT algorithm. Conclusions: Our research revealed that MUC4 mutation significantly correlated with increased TMB, a worse prognosis and modulating the immune microenvironment, which may be considered a biomarker to predict the outcome of the immune response in colorectal cancer.
Insurance Disparity in Cardiovascular Mortality among Non-Elderly Cancer Survivors
Authors: Shi Tiantian , Jiang Changchuan , Zhu Cenjing , Wu Fangcheng , Fotjhadi Irma , Zarich Stuart 
Published: January 2021

Abstract
Background:Insurance status plays a vital role in cancer diagnosis, treatments and survival. Cancer patients have higher cardiovascular disease (CVD) mortality than the general population. Methods: The Surveillance, Epidemiology and End Results (SEER) program 2007-2016 was used to estimate the CVD mortality among cancer patients aged 18 to 64 years at the time of diagnosis of an initial malignancy with the eight most prevalent cancers. Standardized mortality ratios (SMRs) were calculated for each insurance (Private vs Medicaid vs Uninsured) using coded cause of death from CVD with adjustment of age, race, and gender. The Fine-Grey Model was used to estimate adjusted Hazard Ratios (HR) of each insurance in CVD mortality. Results: A total of 768,055 patients were included in the final analysis. CVD death in patients with Medicaid insurance remained higher than in those with private insurance (HR=1.71; 95%CI, 1.61-1.81; p<0.001). Older age, male gender, and black race were all associated with increased CVD mortality in the multivariable model. Compared to the general population, patients with Medicaid had the highest SMRs of CVD mortality, regardless of year of cancer diagnosis, follow-up time, cancer site, and race. Private insured patients had similar CVD mortality to the general population after 2 years out from their cancer diagnosis. Conclusion: Cancer patients with private insurance have significantly lower CVD mortality than those with no insurance or Medicaid. The insurance disparity remained significant regardless of type of CVD, cancer site, year of diagnosis and follow-up time.