bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct Growth of Highly Conductive Large‐Area Stretchable Graphene
Authors: Han Yire , Park Byeong‐Ju , Eom Ji‐Ho , Jella Venkatraju , Ippili Swathi , Pammi S. V. N. , Choi Jin‐Seok , Ha Hyunwoo , Choi Hyuk , Jeon Cheolho , Park Kangho , Jung Hee‐Tae , Yoo Sungmi , Kim Hyun You , Kim Yun Ho , Yoon Soon‐Gil 
Published: February 2021

AbstractThe direct synthesis of inherently defect‐free, large‐area graphene on flexible substrates is a key technology for soft electronic devices. In the present work, in situ plasma‐assisted thermal chemical vapor deposition is implemented in order to synthesize 4 in. diameter high‐quality graphene directly on 10 nm thick Ti‐buffered substrates at 100 °C. The in situ synthesized monolayer graphene displays outstanding stretching properties coupled with low sheet resistance. Further improved mechanical and electronic performances are achieved by the in situ multi‐stacking of graphene. The four‐layered graphene multi‐stack is shown to display an ultralow resistance of ≈6 Ω sq−1, which is consistently maintained during the harsh repeat stretching tests and is assisted by self‐p‐doping under ambient conditions. Graphene‐field effect transistors fabricated on polydimethylsiloxane substrates reveal an unprecedented hole mobility of ≈21 000 cm2 V−1 s−1 at a gate voltage of −4 V, irrespective of the channel length, which is consistently maintained during the repeat stretching test of 5000 cycles at 140% parallel strain.
Highly Selective Detection of Benzene and Discrimination of Volatile Aromatic Compounds Using Oxide Chemiresistors with Tunable Rh‐TiO2 Catalytic Overlayers
Authors: Moon Young Kook , Jeong Seong‐Yong , Jo Young‐Moo , Jo Yong Kun , Kang Yun Chan , Lee Jong‐Heun 
Published: February 2021

AbstractVolatile aromatic compounds are major air pollutants, and their health impacts should be assessed accurately based on the concentration and composition of gas mixtures. Herein, novel bilayer sensors consisting of a SnO2 sensing layer and three different xRh‐TiO2 catalytic overlayers (x = 0.5, 1, and 2 wt%) are designed for the new functionalities such as the selective detection, discrimination, and analysis of benzene, toluene, and p‐xylene. The 2Rh‐TiO2/SnO2 bilayer sensor shows a high selectivity and response toward ppm‐ and sub‐ppm‐levels of benzene over a wide range of sensing temperatures (325–425 °C). An array of 0.5Rh‐, 1Rh‐, and 2Rh‐TiO2/SnO2 sensors exhibits discrimination and composition analyses of aromatic compounds. The conversion of gases into more active species at moderate catalytic activation and the complete oxidation of gases into non‐reactive forms by excessive catalytic promotion are proposed as the reasons behind the enhancement and suppression of analyte gases, respectively. Analysis using proton transfer reaction‐quadrupole mass spectrometer (PTR‐QMS) is performed to verify the above proposals. Although the sensing characteristics exhibit mild moisture interference, bilayer sensors with systematic and tailored control of gas selectivity and response provide new pathways for monitoring aromatic air pollutants and evaluating their health impacts.
Polyaniline‐Coated MOFs Nanorod Arrays for Efficient Evaporation‐Driven Electricity Generation and Solar Steam Desalination
Authors: Li Zhuoyi , Ma Xu , Chen Danke , Wan Xinyi , Wang Xiaobin , Fang Zhou , Peng Xinsheng 
Published: February 2021

AbstractThough evaporation‐driven electricity generation has emerged as a novel eco‐friendly energy and attracted intense interests, it is typically demonstrated in pure water or a very low salt concentration. Integrating evaporation‐driven electricity generation and solar steam desalination simultaneously should be more promising. Herein, a polyaniline coated metal‐organic frameworks (MOFs) nanorod arrays membrane is synthesized which inherits the merits of both polyaniline and MOFs, demonstrating nice stability, good interfacial solar steam desalination, and evaporation‐driven electricity generation. Moreover, an integrated system based on this hybrid membrane achieves good interfacial solar‐heating evaporation and prominently enhanced evaporation‐driven electricity generation under one sun. Notably, the realization of effective seawater desalination and efficient evaporation‐driven electricity generation simultaneously by the non‐carbon‐based materials is reported for the first time, which provides a new alternative way for cogenerating both freshwater and electricity by harvesting energy from seawater and solar light.
The Quality of the Food Retail Environment When Consumers May Be Mobile
Authors: Wilde Parke , Ismail Mehreen , Ver Ploeg Michele 
Published: February 2021

AbstractUsing USDA's National Household Food Acquisition and Purchase Survey (FoodAPS), we estimated block group‐level spending‐weighted mean distance to the retailers where consumers actually shop (3.9 miles overall; 7.0 miles in rural areas and 3.0 miles in urban areas). Holding constant retailer type, every 10% increase in travel distance was associated with a 3.5% decrease in the food‐at‐home spending share. If consumers travel farther to get food, it may signal that they lack satisfactory options at closer distances. Spending‐weighted mean travel distance could support measures of food retail gaps that are consistent both with consumers' revealed preferences and retailers' incentives.
Opportunities and challenges in reducing personal inhalation exposure to air pollution among electronic waste recovery workers in Ghana
Authors: Laskaris Zoey , Batterman Stuart A. , Arko‐Mensah John , Mukherjee Bhramar , Fobil Julius N. , O'Neill Marie S. , Robins Thomas G. 
Published: February 2021

AbstractBackgroundInformal sector electronic waste (e‐waste) recovery produces toxic emissions resulting from burning e‐waste to recover valuable metals.ObjectivesTo identify high‐risk worker groups by measuring relative levels of personal inhalation exposure to particulate matter (PM) of fine (≤2.5 µm) and coarse (2.5–10 µm) fractions (PM2.5 and PM2.5–10, respectively) across work activities among e‐waste workers, and to assess how wind conditions modify levels of PM by activity and site location.MethodsAt the Agbogbloshie e‐waste site, 170 partial‐shift PM samples and time‐activity data were collected from participants (N = 105) enrolled in the GeoHealth cohort study. Personal sampling included continuous measures of size‐specific PM from the worker's breathing zone and time–activity derived from wearable cameras. Linear mixed models were used to estimate changes in personal PM2.5 and PM2.5–10 associated with activities and evaluate effect modification by wind conditions.ResultsMean (±standard deviation) personal PM2.5 and PM2.5–10 concentrations were 80 (±
81) and 123 (± 139) µg m−3, respectively. The adjusted mean PM2.5 concentration for burning e‐waste was 88 µg m−3, a 28% increase above concentrations during non‐recovery activities (such as eating). Transportation‐related and burning activities were associated with the highest PM2.5–10 concentrations. Frequent changes in wind direction were associated with higher PM2.5 concentrations when burning, and high wind speeds with higher PM2.5–10 concentrations when dismantling e‐waste downwind of the burning zone.
Phenotypic expansion of the BPTF‐related neurodevelopmental disorder with dysmorphic facies and distal limb anomalies
Authors: Glinton Kevin E. , Hurst Anna C. E. , Bowling Kevin M. , Cristian Ingrid , Haynes Devon , Adstamongkonkul Dusit , Schnappauf Oskar , Beck David B. , Brewer Carole , Parikh Aditi Shah , Shinde Deepali N. , Donaldson Alan , Brautbar Ariel , Koene Saskia , van Haeringen Arie , Piton Amélie , Capri Yline , Furlan Margherita , Gardella Elena , Møller Rikke Steensbjerre , van de Beek Irma , Zuurbier Linda , Lakeman Phillis , Bayat Allan , Martinez Julian , Signer Rebecca , Torring Pernille M. , Engelund Morten Buch , Gripp Karen W. , Amlie‐Wolf Louise , Henderson Lindsay B. , Midro Alina T. , Tarasów Eugeniusz , Stasiewicz‐Jarocka Beata , Moskal‐Jasinska Diana , Vos Paul , Boschann Felix , Stoltenburg Corinna , Puk Oliver , Mero Inger‐Lise , Lossius Kristine , Mignot Cyril , Keren Boris , Acosta Guio Johanna C. , Briceño Ignacio , Gomez Alberto , Yang Yaping , Stankiewicz Pawel 
Published: February 2021

AbstractNeurodevelopmental disorder with dysmorphic facies and distal limb anomalies (NEDDFL), defined primarily by developmental delay/intellectual disability, speech delay, postnatal microcephaly, and dysmorphic features, is a syndrome resulting from heterozygous variants in the dosage‐sensitive bromodomain PHD finger chromatin remodeler transcription factor BPTF gene. To date, only 11 individuals with NEDDFL due to de novo BPTF variants have been described. To expand the NEDDFL phenotypic spectrum, we describe the clinical features in 25 novel individuals with 20 distinct, clinically relevant variants in BPTF, including four individuals with inherited changes in BPTF. In addition to the previously described features, individuals in this cohort exhibited mild brain abnormalities, seizures, scoliosis, and a variety of ophthalmologic complications. These results further support the broad and multi‐faceted complications due to haploinsufficiency of BPTF.
Early prenatal diagnosis of alveolar capillary dysplasia with misalignment of pulmonary veins due to a 16q24.1 deletion
Authors: Puisney‐Dakhli Chloé , Gubana Francesca , Petit François , Bouchghoul Hanane , Gautier Valérie , Martinovic Jelena , Tachdjian Gérard , Receveur Aline 
Published: February 2021

AbstractFirst trimester ultrasound screening is an essential fetal examination performed generally at 11–13 weeks of gestation (WG). However, it does not allow for an accurate description of all fetal organs, partly due to their development in progress. Meanwhile, increased nuchal translucency (INT) is a widely used marker known to be associated with chromosomal deleterious rearrangements. We report on a 14 WG fetus with an association of INT and univentricular congenital heart malformation (CHM) leading to chorionic villous sampling (CVS). Cytogenetic investigations performed using array‐Comparative Genomic Hybridization (CGH) and fluorescence in situ hybridization (FISH) demonstrated a 1.17 Mb deletion in 16q24.1 encompassing FOXF1 arisen de novo on maternal inherited chromosome. Fetopathological study confirmed CHM with hypoplastic left heart syndrome (HLHS) associating aortic atresia, mitral stenosis, and left ventricular hypoplasia and revealed in addition specific lung lesions corresponding to alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV). This is so far the first case of first trimester prenatal diagnosis of ACDMPV due to the deletion of FOXF1 gene. An interpretation of the complex genomic data generated by ultrasound markers is facilitated considerably by the genotype–phenotype correlations on fetopathological examination.
Dithiophene‐Fused Oxadiborepins and Azadiborepins: A New Class of Highly Fluorescent Heteroaromatics
Authors: Crumbach Merian , Bachmann Jonas , Fritze Lars , Helbig Andreas , Krummenacher Ivo , Braunschweig Holger , Helten Holger 
Published: February 2021

AbstractAccess to dithiophene‐fused oxadiborepins and the first azadiborepins attained via a modular synthesis route are presented. The new compounds emit intense blue light, some of which demonstrate fluorescence quantum yields close to unity. Cyclic voltammetry (CV) revealed electrochemically reversible one‐electron reduction processes. The weak aromatic character of the novel 1,2,7‐azadiborepin ring is demonstrated with in‐depth theoretical investigations using nucleus‐independent chemical shift (NICS) scans and anisotropy of the induced current density (ACID) calculations.
Histone H4 Tails in Nucleosomes: a Fuzzy Interaction with DNA
Authors: Rabdano Sevastyan O. , Shannon Matthew D. , Izmailov Sergei A. , Gonzalez Salguero Nicole , Zandian Mohamad , Purusottam Rudra N. , Poirier Michael G. , Skrynnikov Nikolai R. , Jaroniec Christopher P. 
Published: February 2021

AbstractThe interaction of positively charged N‐terminal histone tails with nucleosomal DNA plays an important role in chromatin assembly and regulation, modulating their susceptibility to post‐translational modifications and recognition by chromatin‐binding proteins. Here, we report residue‐specific 15N NMR relaxation rates for histone H4 tails in reconstituted nucleosomes. These data indicate that H4 tails are strongly dynamically disordered, albeit with reduced conformational flexibility compared to a free peptide with the same sequence. Remarkably, the NMR observables were successfully reproduced in a 2‐μs MD trajectory of the nucleosome. This is an important step toward resolving an apparent inconsistency where prior simulations were generally at odds with experimental evidence on conformational dynamics of histone tails. Our findings indicate that histone H4 tails engage in a fuzzy interaction with nucleosomal DNA, underpinned by a variable pattern of short‐lived salt bridges and hydrogen bonds, which persists at low ionic strength (0–100 mM NaCl).
Lipopolysaccharide from Gut‐Associated Lymphoid‐Tissue‐Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A
Authors: Shimoyama Atsushi , Di Lorenzo Flaviana , Yamaura Haruki , Mizote Keisuke , Palmigiano Angelo , Pither Molly D. , Speciale Immacolata , Uto Tomoya , Masui Seiji , Sturiale Luisa , Garozzo Domenico , Hosomi Koji , Shibata Naoko , Kabayama Kazuya , Fujimoto Yukari , Silipo Alba , Kunisawa Jun , Kiyono Hiroshi , Molinaro Antonio , Fukase Koichi 
Published: February 2021

AbstractAlcaligenes faecalis is the predominant Gram‐negative bacterium inhabiting gut‐associated lymphoid tissues, Peyer's patches. We previously reported that an A. faecalis lipopolysaccharide (LPS) acted as a weak agonist for Toll‐like receptor 4 (TLR4)/myeloid differentiation factor‐2 (MD‐2) receptor as well as a potent inducer of IgA without excessive inflammation, thus suggesting that A. faecalis LPS might be used as a safe adjuvant. In this study, we characterized the structure of both the lipooligosaccharide (LOS) and LPS from A. faecalis. We synthesized three lipid A molecules with different degrees of acylation by an efficient route involving the simultaneous introduction of 1‐ and 4′‐phosphates. Hexaacylated A. faecalis lipid A showed moderate agonistic activity towards TLR4‐mediated signaling and the ability to elicit a discrete interleukin‐6 release in human cell lines and mice. It was thus found to be the active principle of the LOS/LPS and a promising vaccine adjuvant candidate.
Natural cyclic polypeptides as vital phytochemical constituents from seeds of selected medicinal plants
Authors: Dahiya Rajiv , Dahiya Sunita , Shrivastava Jyoti , Fuloria Neeraj K. , Gautam Hemendra , Mourya Rita , Fuloria Shivkanya 
Published: February 2021

AbstractCyclopolypeptides are among the most predominant biomolecules in nature, especially those derived from plant seeds. This category of compounds has gained extraordinary attention due to remarkable variety of structures and valuable biofunctions. These congeners display enormous variation in terms of both structure and function and are the most significant biomolecules due to their widespread bioproperties. The estrogenic activity, immunosuppressive activity, cytotoxicity, vasorelaxant activity, and other properties possessed by cyclic peptides from seeds of plants make these congeners attractive leads for the drug discovery process. The current study covers the important structural features, structure–activity relationship, synthesis methods, and bioproperties of plant seeds‐originated bioactive peptides from Vaccaria segetalis, Linum usitatissimum, and Goniothalamus leiocarpus, which may prove vital for the development of novel therapeutics based on a peptide skeleton.
Moderate intensity aerobic exercise during pregnancy and 1‐month infant Morphometry
Authors: McDonald Samantha M. , Isler Christy , Haven Kelley , Newton Edward , Kuehn Devon , Kelley George , Chasan‐Taber Lisa , May Linda E. 
Published: February 2021

AbstractObjectiveAssess the effects of supervised, prenatal aerobic exercise intervention on 1‐month‐old neonatal morphometry.MethodsSecondary data analyses of a 24+ week, randomized controlled exercise intervention trial in pregnant women between 2015 and 2018 were performed. Eligibility criteria included pregnant women: <16 weeks of gestation, singleton pregnancy, aged 18–40 years, and body mass index of 18.5–35.00 kg∙m2. Eligible pregnant women (n = 128) were randomly assigned a moderate‐intensity aerobic exercise group (n = 68) or a nonexercising group (n = 60) consisting of light stretching and breathing techniques. Neonatal weight, skinfold thickness, circumferences, and fat‐free mass were measured at 1‐month of age. Covariates included weight gain, gestational diabetes mellitus, and neonatal sex. ANCOVAs for intention‐to‐treat (ITT) and per protocol were performed.ResultsITT and per protocol analyses included 74 and 56 participants, respectively. Adjusted regression results showed significant between‐group differences for neonatal skinfold thickness (ITT: 20.0 mm vs. 22.2 mm; p = .04; per protocol: 19.8 mm vs. 22.3 mm; p = .03) and body fat (per protocol 13.2% vs. 15.1%; p = .05). No between‐group differences for weight (p = .36, .25), abdominal (p = .08, .35) and mid‐upper arm circumferences (p = .30, .26), or fat‐free mass (p = .83, .69).ConclusionThe study findings suggest that aerobic exercise has a beneficial impact on neonatal skinfold thickness and percent body fat at 1 month of age. Participation in the recommended levels of aerobic exercise (150 min, moderate‐intensity per week) throughout the prenatal period may serve as an effective strategy to reduce the risk of overweight or obesity in the early postnatal period.
Photoluminescence and mechanoluminescence of solid‐state zirconocene dichlorides
Authors: Tukhbatullin Adis A. , Kovyazin Pavel V. , Sharipov Glyus L. , Parfenova Lyudmila V. , Ivchenko Pavel V. , Nifant'ev Ilya E. 
Published: February 2021

AbstractSpectral‐luminescence properties of 23 samples of zirconium complexes were studied. Mechanoluminescence spectra of 10 complexes were obtained. The solid‐state component of the mechanoluminescence spectrum, that is the luminescence of the crystal itself, coincided with the photoluminescence spectra of these complexes, which indicated identical emission from the same excited states in mechanoluminescence and photoluminescence, despite the different ways of excitation. The luminescence maximum was red shifted as substituents appeared in the ligand, in particular in the presence of a bridging group connecting π‐ligands (ansa‐complexes) and also for a substituted bis‐indenyl complex rac‐Me2Si(2‐Me‐4‐Ph‐5‐OMe‐6‐But‐Ind)2ZrCl2). It was found that mechanical destruction of the rac‐isomer of complex Mе2С(2‐Me‐4‐But‐C5H2)2ZrCl2, unlike that of the meso‐isomer, was accompanied by a more than a 10‐fold increase in intensity and by a shift in the mechanoluminescence spectrum to longer wavelengths.
Management of peri‐device leak following left atrial appendage closure: A systematic review
Authors: Sleiman Jose R. , Lewis Antonio J. , Perez Eduardo J. , Sanchez Alexandra M. , Baez‐Escudero Jose L. , Navia Jose L. , Asher Craig R. , Cubeddu Robert J. 
Published: February 2021

AbstractObjectiveThis study aimed to examine the cumulative experience of peri‐device leak (PDL) closure following left atrial appendage (LAA) closure.BackgroundThe management of PDL following LAA closure remains controversial. While PDL closure has been proposed, procedural features and clinical outcomes have not been well established.MethodsA systematic review of all published cases of PDL closure with available anatomical, procedural, and clinical outcomes was performed.ResultsWe identified 18 indexed publications and 110 cases between April 2013 and March 2020. 71 patients (mean age 72 ± 8 yrs), met study criteria and were included. PDL closure was most common in males, bilobar LAA morphology, and after Watchman procedures. The mean PDL size was 7.6 ± 5.8 mm (range 2–26 mm). Leaks were classified according to size: small (<5 mm; 45%), moderate (≥5–9 mm; 25%), and large (≥10 mm; 30%). Endovascular coils and endovascular plugs were used to close both small and moderate sized leaks, and second LAA closure devices were exclusively used for large PDLs. Successful PDL closure occurred in 90%, and was similar between PDL sizes and types of occluder used. Procedural complication rates were uncommon (2.8%). No strokes were reported following PDL closure at 6 months.ConclusionsIn patients with PDL for whom discontinuation of OAC may be considered unsafe, percutaneous closure using a tailored approach with either endovascular coils, plugs, or second occluder represents a safe, and feasible alternative associated with favorable clinical outcomes.
Engineered Bifunctional Luminescent Pillared‐Layer Frameworks for Adsorption of CO2 and Sensitive Detection of Nitrobenzene in Aqueous Media
Authors: Su Chun‐Hao , Tsai Meng‐Jung , Wang Wei‐Kai , Li Yi‐Yun , Wu Jing‐Yun 
Published: February 2021

AbstractThrough a dual‐ligand synthetic approach, five isoreticular primitive cubic (pcu)‐type pillared‐layer metal–organic frameworks (MOFs), [Zn2(dicarboxylate)2(NI‐bpy‐44)]⋅x DMF⋅y H2O, in which dicarboxylate=1,4‐bdc (1), Br‐1,4‐bdc (2), NH2‐1,4‐bdc (3), 2,6‐ndc (4), and bpdc (5), have been engineered. MOFs 1–5 feature twofold degrees of interpenetration and have open pores of 27.0, 33.6, 36.8, 52.5, and 62.1 %, respectively. Nitrogen adsorption isotherms of activated MOFs 1′–5′ at 77 K all displayed type I adsorption behavior, suggesting their microporous nature. Although 1′ and 3′–5′ exhibited type I adsorption isotherms of CO2 at 195 K, MOF 2′ showed a two‐step gate‐opening sorption isotherm of CO2. Furthermore, MOF 3′ also had a significant influence of amine functions on CO2 uptake at high temperature due to the CO2–framework interactions. MOFs 1–5 revealed solvent‐dependent fluorescence properties; their strong blue‐light emissions in aqueous suspensions were efficiently quenched by trace amounts of nitrobenzene (NB), with limits of detection of 4.54, 5.73, 1.88, 2.30, and 2.26 μm, respectively, and Stern–Volmer quenching constants (Ksv) of 2.93×103, 1.79×103, 3.78×103, 4.04×103, and 3.21×103 m−1, respectively. Of particular note, the NB‐included framework, NB@3, provided direct evidence of the binding sites, which showed strong host–guest π–π and hydrogen‐bonding interactions beneficial for donor–acceptor electron transfer and resulting in fluorescence quenching.
E7766, a Macrocycle‐Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan‐Genotypic Activity
Authors: Kim Dae‐Shik , Endo Atsushi , Fang Francis G. , Huang Kuan‐Chun , Bao Xingfeng , Choi Hyeong‐wook , Majumder Utpal , Shen Young Y. , Mathieu Steven , Zhu Xiaojie , Sanders Kristen , Noland Thomas , Hao Ming‐Hong , Chen Yu , Wang John Y. , Yasui So , TenDyke Karen , Wu Jiayi , Ingersoll Christy , Loiacono Kara A. , Hutz Janna E. , Sarwar Nadeem 
Published: February 2021

AbstractA strategy for creating potent and pan‐genotypic stimulator of interferon genes (STING) agonists is described. Locking a bioactive U‐shaped conformation of cyclic dinucleotides by introducing a transannular macrocyclic bridge between the nucleic acid bases leads to a topologically novel macrocycle‐bridged STING agonist (MBSA). In addition to substantially enhanced potency, the newly designed MBSAs, exemplified by clinical candidate E7766, exhibit broad pan‐genotypic activity in all major human STING variants. E7766 is shown to have potent antitumor activity with long lasting immune memory response in a mouse liver metastatic tumor model. Two complementary stereoselective synthetic routes to E7766 are also described.