bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Cyanoacrylate in Reducing Seroma Formation in Breast Cancer Patients Post-Axillary Dissection: A Randomized Controlled Trial
Authors: Al-Masri Mahmoud , Alawneh Fade , Daoud Faiez , Ebous Ali , Hamdan Basem , Al-Najjar Hani , Al-Masri Rama , Abufara Marwan 
Published: January 2021

Background/PurposeSeroma is a common complication after axillary dissection in women with node-positive breast cancer. We aim to determine the effect of Cyanoacrylate on reducing seroma formation in patients undergoing axillary dissection. This a randomized clinical trial.MethodsThis is a single-center, randomized, single-blinded, and two-arm parallel study. Women with node-positive breast cancer eligible for axillary dissection were enrolled. Patients with a Body Mass Index (BMI) greater than 35 kg/m2, those who underwent immediate breast reconstruction, and/or received neoadjuvant chemotherapy were excluded. Patients were randomized in a 1:1 ratio, and were stratified according to their age, BMI, tumor size, and operation type. The primary endpoint was the total seroma volume (the total drained volume and the total aspirated volume after drain removal). Data presented as mean and range when applicable.Results111 patients were randomized (Cyanoacrylate 57; control 54). 105 patients were analyzed. Sixty-nine patients underwent breast conserving surgery, and 36 underwent modified radical mastectomy. There was no difference in the total seroma volume between the Cyanoacrylate vs. control arms (1,304 (60–4,950) vs. 1,446 (100–5,223) ml, p=0.458). Wound infection, flap necrosis, number of manual aspirates, and hematoma formation were not statistically different between the two groups. Time to drain removal was shorter in the Cyanoacrylate arm (11.04(3–23) vs. 13.84(3–37) days, p=0.015). The use of Cyanoacrylate was not cost effective ($586.93 (550–748) vs. $29.63 (0–198), p&lt;0.001). Higher seroma volume was correlated with modified radical mastectomy, older age, and BMI more than 30 kg/m2.ConclusionCyanoacrylate did not reduce seroma formation and its use was not cost effective.Clinical Trial Registrationclinicaltrials.gov, identifier NCT02141373.
Elevated Heterogeneous Nuclear Ribonucleoprotein C Expression Correlates With Poor Prognosis in Patients With Surgically Resected Lung Adenocarcinoma
Authors: Guo Wei , Huai Qilin , Zhang Guochao , Guo Lei , Song Peng , Xue Xuemin , Tan Fengwei , Xue Qi , Gao Shugeng , He Jie 
Published: January 2021

BackgroundLung adenocarcinoma (LUAD), as the most common histological subtype of lung cancer, is a high-grade malignancy and a leading cause of cancer-related death globally. Identification of biomarkers with prognostic value is of great significance for the diagnosis and treatment of LUAD. Heterogeneous nuclear ribonucleoprotein C (HNRNPC) is an RNA-binding protein “reader” of N6-methyladenosine (m6A) methylation, and is related to the progression of various cancers; however, its role in LUAD is unclear. The aims of this study aims were to study the expression and prognostic value of HNRNPC in LUAD.MethodsThe Oncomine database and gene expression profiling interactive analysis (GEPIA) were used for preliminary exploration of HNRNPC expression and prognostic value in LUAD. LUAD cases from The Cancer Genome Atlas (TCGA) (n = 416) and the Kaplan-Meier plotter database (n = 720) were extracted to study the differential expression and prognostic value of HNRNPC. HNRNPC expression in the National Cancer Center of China (NCC) cohort was analyzed by immunohistochemical staining, and the relationship between HNRNPC expression and survival rate evaluated using the Kaplan-Meier method and log-rank test. Univariate and multivariate Cox regression analyses were used to identify independent prognostic factors. Several pathways that were significantly enriched in the HNRNPC high expression group were identified by Gene Set Enrichment Analysis (GSEA).ResultsFive data sets from the Oncomine and GEPIA databases all supported that HNRNPC expression is significantly higher in LUAD than in normal lung tissue. In TCGA cohort, HNRNPC was highly expressed in LUAD tissues and significantly related to age, sex, smoking history, ethnicity, lymph node metastasis, and TNM staging (P &lt; 0.001). High HNRNPC expression was significantly correlated with poor prognosis in the three cohorts (NCC, TCGA, and K-M plotter) (P &lt; 0.05). Multivariate Cox regression analysis showed that HNRNPC expression was an independent prognostic factor in both TCGA and NCC cohorts (P &lt; 0.05). Further, 10 significantly enriched pathways were identified from TCGA data and 118 lung cancer cell lines in CCLE, respectively.ConclusionsHigh HNRNPC expression is significantly related to poor overall survival in patients with LUAD, suggesting that HNRNPC may be a cancer-promoting factor and a potential prognostic biomarker in LUAD.
Application of Gastroscopy in the Diagnosis of Congenital Pyriform Sinus Fistula in Children
Authors: Wang Shengcai , Mei Lin , Li Yanzhen , Zhang Xuexi , Zhang Jie , Ge Wentong , Guo Yongli , Yu Yongbo , Wang Guoli , Mei Tianlu , Liu Qiaoyin , Sun Nian , He Yuzhu , Li Xiaodan , Liu Yuwei , Tai Jun , Ni Xin 
Published: January 2021

Objective: The aim of this study was to explore the diagnostic value of gastroscopy under local anesthesia for congenital pyriform sinus fistula (CPSF).Methods: This research was a diagnostic study. Patients received gastroscopy under local anesthesia to diagnose CPSF, and suspension laryngoscopy under general anesthesia was performed 2 days after gastroscopy. Various conditions of the internal opening of CPSF were then recorded. Patients were grouped according to lesion sides, age, time after the inflammation subsided, and history of previous surgery. The sensitivity, specificity, area under the receiver operating characteristic curve (AUC), accuracy, and positive and negative predictive values of gastroscopy were compared between the groups.Results: A total of 48 patients were recruited in this study, and no patients had severe gastroscopy-related complications. The diagnostic values of gastroscopy in 41 cases (85.4%) were consistent with suspension laryngoscopy. The sensitivity of gastroscopy was 86.4%, the specificity was 75%, the AUC was 0.807, the positive prediction rate was 97.4%, the negative prediction rate was 33.3%, the accuracy rate was 85.4%, and the diagnostic odds ratio (DOR) was 2.1. The kappa consistency test results had statistical significance (P = 0.0026, kappa = 0.3913). The diagnostic value of gastroscopy was better for the patients with inflammation subsiding for more than 4 weeks (P &lt; 0.0001).Conclusion: Gastroscopy under local anesthesia is a safe, effective, reliable and novel diagnostic method for CPSF, and it is especially recommended as a diagnostic method for the patients with inflammation subsiding for more than 4 weeks.
Clinical Classifications of Children With Psychogenic Non-epileptic Seizure
Authors: Zhang Li-Ping , Jia Yu , Huang Hao , Li Da-Wei , Wang Yu-Ping 
Published: January 2021

Objective: To analyze the clinical features of children with psychogenic non-epileptic seizures in one tertiary center in China.Methods: Clinical data including medical records and video- electroencephalograph (video-EEG) monitoring records of 88 pediatric PNES patients hospitalized in the pediatric department of Xuanwu Hospital, Beijing, China from April, 2012 to April, 2018 were collected in this study. Demographic information of patients, semiological classification, duration, and frequency of symptoms, risk factors as well as comorbidity were summarized and analyzed.Results: For semiological classification, all PNES related symptoms were divided into different categories: motor symptoms, unresponsiveness, sensory symptoms, visceral symptoms, and abnormal behaviors, among which motor symptoms were the most prevalent form. Risk factors were reviewed and categorized into two groups: persistent factors and predisposing factors, and patients were most frequently affected by the influences of families. The duration and frequency of symptoms varied substantially within PNES patients while the average time of duration was relatively longer than epilepsy as reported previously. Epilepsy was considered as the most frequent comorbidity of PNES and PNES patients misdiagnosed as epilepsy often mistreated with antiseizure medication.Significance: Our study showed that motor PNES are the most frequent seizure type. Family issues were a risk factor for PNES. Epilepsy was the most frequent co-existing neurological comorbidity.
Aloperine Relieves Type 2 Diabetes Mellitus via Enhancing GLUT4 Expression and Translocation
Authors: Song Guanjun , Huang Yun , Xiong Mingrui , Yang Ziwei , Liu Qinghua , Shen Jinhua , Zhao Ping , Yang Xinzhou 
Published: January 2021

Aloperine (ALO), a quinolizidine alkaloid isolated from Sophora alopecuroides L. used in the traditional Uygur medicine, induced a significant increase in cellular glucose uptake of L6 cells, suggesting it has the potential to relieve hyperglycemia. Therefore, we investigated the effects of ALO on type 2 diabetes mellitus (T2DM) through in vitro and in vivo studies. The translocation of glucose transporter 4 (GLUT4) and changes in intracellular Ca2+ levels were real-time monitored in L6 cells using a laser scanning confocal microscope and related protein kinase inhibitors were used to explore the mechanism of action of ALO. Furthermore, high fat diet combined with low-dose streptozotocin (STZ) was used to induce T2DM in rats, and ALO was given to the stomach of T2DM rats for 4 weeks. In vitro results showed that ALO-induced enhancement of GLUT4 expression and translocation were mediated by G protein-PLC-PKC and PI3K/Akt pathways and ALO-enhanced intracellular Ca2+ was involved in activating PKC via G protein-PLC-IP3R-Ca2+ pathway, resulting in promoted GLUT4 plasma membrane fusion and subsequent glucose uptake. ALO treatment effectively ameliorated hyperglycemia, glucose intolerance, insulin resistance and dyslipidemia, alleviated hepatic steatosis, protected pancreatic islet function and activated GLUT4 expression in insulin target tissues of T2DM rats. These findings demonstrated that ALO deserves attention as a potential hypoglycemic agent.
Synthesis, Characterization, Cellular Uptake, and In Vitro Anticancer Activity of Fullerenol-Doxorubicin Conjugates
Authors: Xu Beihua , Yuan Li , Hu Ying , Xu Zhiyuan , Qin Jiang-Jiang , Cheng Xiang-Dong 
Published: January 2021

Doxorubicin (DOX) is one of the most commonly used chemotherapeutic agents for treating human cancer. However, its clinical use has been limited by DOX-induced cardiotoxicity as well as other side effects. In the present study, we designed and synthesized the fullerenol (FU)-DOX conjugates and folic acid (FA)-grafted FU-DOX conjugates for improving the selectivity and activity of DOX in cancer cells. We further characterized the physicochemical properties and examined the release kinetics, cellular uptake, and in vitro anticancer activities of FU-DOX and FA-FU-DOX. The results showed that FU-DOX and FA-FU-DOX had a mean diameter of &lt;200 nm and a low polydispersity. Both FU-DOX and FA-FU-DOX exhibited pH sensitivity and their DOX release rates were higher at pH 5.9 vs. pH 7.4. The cellular uptake studies indicated that FU conjugation enhanced the intracellular accumulation of DOX in human hepatocellular carcinoma (HCC) cell lines (BEL-7402 and HepG2) and the immortalized normal human hepatocytes (L02). The conjugation of FA to FU-DOX further promoted the drug internalization in an FR-dependent manner and enhanced the cytotoxicity against HCC cells. In conclusion, the newly prepared FA-FU-DOX conjugates can optimize the safety and efficacy profile of DOX.
Geriatric Nutritional Risk Index as a Prognostic Marker for Patients With Metastatic Castration-Resistant Prostate Cancer Receiving Docetaxel
Authors: Chang Li-Wen , Hung Sheng-Chun , Li Jian-Ri , Chiu Kun-Yuan , Yang Cheng-Kuang , Chen Chuan-Shu , Lu Kevin , Chen Cheng-Che , Wang Shu-Chi , Lin Chia-Yen , Cheng Chen-Li , Ou Yen-Chuan , Yang Shun-Fa , Hsu Chiann-Yi , Ho Szu-Hang , Wang Shian-Shiang 
Published: January 2021

Purpose: To investigate the prognostic efficacy of the Geriatric Nutritional Risk Index (GNRI) in patients with metastatic Castration–resistant Prostate Cancer (mCRPC) receiving docetaxel as the first line of treatment.Methods: We retrospectively reviewed patients with mCRPC and receiving first line docetaxel in Taichung Veterans General Hospital from 2006 to 2012. The GNRI was calculated using serum albumin and body mass index, with a poor nutritional status defined as GNRI &lt;92.0. Multivariate Cox-regression analysis was used to evaluate the risk of survival.Results: One-hundred seventy patients with mCRPC were included. One-hundred twenty-five patients were of normal nutritional status (GNRI ≥92) and 45 patients were of poor nutritional status (GNRI &lt;92). The cumulative docetaxel dosage was 600 (360–1,185) mg in the normal nutritional status group and 360 (127.5–660) mg in the poor nutritional status group (p &lt; 0.001). The median overall survival from mCRPC was 30.39 months in the good nutritional status group and 11.07 months in the poor nutritional status group (p of log rank &lt;0.001). In a multivariate model, poor nutritional status was an independent risk factor in overall survival (Hazard Ratio [HR] = 5.37, 95% Confidence Interval [CI] 3.27–8.83), together with a high metastatic volume (HR = 4.03, 95% CI 2.16–7.53) and docetaxel cumulative dosage (HR = 0.999, 95% CI 0.999–0.9998).Conclusion: Poor nutritional status with a GNRI &lt;92 is associated with shorter progression free survival and overall survival in mCRPC patients treated with docetaxel. Metastatic volume and cumulative docetaxel dosage are also independent prognostic factors in overall survival.
ANALISIS TINGKAT KEPUASAN PENGGUNA LULUSAN TERHADAP LULUSAN PENDIDIKAN VOKASI (STUDI KASUS LULUSAN POLITEKNIK LP3I MEDAN)
Authors: Hanum Zubaidah 
Published: January 2021

This study aimed to know the level of satisfaction of companies that occupied Polytechnic LP3I Medan graduates. The sample of this study is purposive sampling. There were 22 relations companies Polytechnic LP3I Medan that occupy its graduates. The method in this study is Importance Performance Analysis (IPA). It is a method with identification of services quality level in a service industry which has 5 dimensions, such as Tangibles, Reliability, Responsiveness, Assurance, and Empathy. By analyzing the gap occurred because of the imbalance between priority level and graduates-user perception with services quality they got. Based on the study, it could be formulated that the company that occupy Polytechnic LP3I Medan graduates felt satisfied, even it hasn’t been as what they intend
Keywords: Vocational education, services quality, Important Performance Analysis

Tujuan penelitian ini adalah untuk mengetahui tingkat kepuasan perusahaan pengguna lulusan politeknik LP3I Medan. Sampel dalam penelitian ini adalah pusposive sampling berjumlah 22 Perusahaan yang merupakan relasi Politeknik LP3I Medan yang terus menggunakan lulusan. Metode penelitian yang digunakan adalah Importance Performance Analysis (IPA) yaitu metode yang mengidentifikasi level kualitas pelayanan suatu industri jasa yang terdiri dari lima dimensi kualitas pelayanan yaitu Tangibles (bentuk fisik), Reability (dapat diandalkan), Responsiveness (daya tanggap), Assurance (Jaminan), Empaty (Empati) dengan menganalisis kesenjangan yang terjadi akibat ketidak sesuaian antara tingkat kepentingan dan persepsi pengguna lulusan terhadap kualitas layanan yang didapatkannya. Berdasarkan hasil penelitian dapat disimpulkan bahwa pengguna lulusan Politeknik LP3I Medan adalah Puas namun belum sesuai dengan yang diharapkan perusahaan.
Kata kunci: Pendidikan vokasi, kualitas layanan, Important Perfomance Analysis
Comparative evaluation of methods for freezing meatraw materials with a different nature of autolysis
Authors: Litvinova E. V. , Artamonova M. P. , Bukhteeva J. M. 
Published: January 2021

Learning of quality indicators of meat in the process cryogenic freezing method with different nature of autolysis has a special relevant meaning in the context of increasing interest in ensure effective health saving of nation and promotion of the theory of resourse saving industries as part of accordance and introduction of the best technologies. Realization of comparative assessment of changes in meat quality indicators of NOR and DFD beef and pork depending on various freezing ways was the goal of original research. As part of the work we have been using TR CU 021/2011, TR CU 034/2013, Guidelines 4.2.2747-10 and State Standard. As a result of research we have found nature of the change in the properties of meat depending on freezing ways (aerial, cryogenic, acoustic) and autolysis (DFD beef, DFD pork, NOR beef, pork NOR). During storage of freezing meat within 6 months moisture doesn’t freeze from sarcoplasm of muscle fibers, which moves into interfiber space. We established that frozen meat by cryogenic method has smallest changes and also with using of the acoustic influence. In any modes of freezing both DFD beef and pork showed the greatest stability of indicators. Results of the research open additional technological properties of meat with different nature of autolysis, what plays important practical role for meat processing industries.
The problems of presence of weeds in the crops begin with seeds
Authors: Ivashchenko O. , Remenyuk S. 
Published: January 2021

Goal. Determine the level of potential abrasion of arable land in the main soil-climatic zones of the country.
Methods. Used methods of analysis and synthesis, method of comparison.
Results. The total reserves of different types of weed seeds in the earth’s horizon 0—10 cm in the main soil-climatic zones of the country on average are: Polissya — 49 thousand pieces/m2; in the forest-steppe zone — 57 thousand pieces/m2; in the Steppe area on average — 57 thousand pieces/m2. Accordingly, during the warm period of the year, 1 m2 of arable land area is able to sprout and form stairs of weeds of various types of weeds on average: in the Polissya area — 1887 pieces; in the zone of forest-steppe — 4674 pieces; in the Steppe zone — 2242 pieces. Basically, these types of tetrophytes are annual weed species, for which the main way of reproduction and distribution is the fruits and seeds: millet cock Echinochloa crus-galli (L.) Pal. Beauv.; Loboda white Chenopodium album L., Common curd (curved) Amaranthus retroflexus L., Field mustard Sinapis arvensis L., Black passion black Solanum nigrum L. and others.
Conclusions. Reducing the costs of systems for protecting crops from crops from weeds is possible, in the first place, with the reduction of the depot volume of their seeds in the arable layer of soil.
Control of butters in lines culinaris medic
Authors: Reznik V. , Moshkovska S. 
Published: January 2021

Goal. To develop an effective system for the protection of crops of lentils from weeds by chemical methods. Objective: to investigate the dynamics of the processes of weed infestation, the species composition of weeds, the structure, number and mass of weeds; to study the factors of the negative impact of weeds on lentil plants in the process of their joint vegetation; search and evaluation in field conditions of the effectiveness of herbicides and their compositions on edible lentil crops.
Methods. Common and special methods: field — the study of the influence of growing conditions and winter hardiness on the performance indicators of edible lentils; laboratory — determination of quantitative and qualitative signs; statistical — the establishment of mathematical models and statistical dependencies between the studied factors and processes.
Results. It has been established that with the use of the herbicide Zenkor, 70WG, the consumption rate of 0.6 kg / ha of edible lentil yield was 1.45 t / ha and was the highest in the experience with the use of herbicides.
Conclusion. Edible lentil weeds are dangerous competitors for life factors of plant crops. The presence of weeds in crops during the entire vegetation can reduce the yield of seeds by 86.7%. For a high yield of lentil seed, reliable protection against weeds is a prerequisite.
The Hubble WFC3 Emission Spectrum of the Extremely Hot Jupiter KELT-9b
Authors: Changeat Quentin , Edwards Billy 
Published: January 2021

Abstract
Recent studies of ultra-hot Jupiters suggested that their atmospheres could have thermal inversions due to the presence of optical absorbers such as titanium oxide (TiO), vanadium oxide (VO), iron hydride (FeH), and other metal hydride/oxides. However, it is expected that these molecules would thermally dissociate at extremely high temperatures, thus leading to featureless spectra in the infrared. KELT-9 b, the hottest exoplanet discovered so far, is thought to belong to this regime and host an atmosphere dominated by neutral hydrogen from dissociation and atomic/ionic species. Here, we analyzed the eclipse spectrum obtained using the Hubble Space Telescope’s Wide Field Camera 3 and, by utilizing the atmospheric retrieval code TauREx3, found that the spectrum is consistent with the presence of molecular species and is poorly fitted by a simple blackbody. In particular, we find that a combination of TiO, VO, FeH, and H- provides the best fit when considering Hubble Space Telescope (HST), Spitzer, and TESS data sets together. Aware of potential biases when combining instruments, we also analyzed the HST spectrum alone and found that TiO and VO only were needed in this case. These findings paint a more complex picture of the atmospheres of ultra-hot planets than previously thought.
The Landscape of Galaxies Harboring Changing-look Active Galactic Nuclei in the Local Universe
Authors: Dodd Sierra A. , Law-Smith Jamie A. P. , Auchettl Katie , Ramirez-Ruiz Enrico , Foley Ryan J. 
Published: January 2021

Abstract
We study the properties of the host galaxies of changing-look active galactic nuclei (CL AGNs) with the aim of understanding the conditions responsible for triggering CL activity. We find that CL AGN hosts primarily reside in the so-called green valley that is located between spiral-like star-forming galaxies and dead ellipticals, implying that CL AGNs are activated during distinct periods of quenching and galaxy transformation processes. CL AGN hosts have low galaxy asymmetry indicators, suggesting that secular evolutionary processes (the influence of bars and spirals, and possibly minor mergers) might be the primary mechanism for transporting gas to the vicinity of the supermassive black hole (SMBH) rather than major mergers. Similar to tidal disruption events and highly variable AGNs, we find that CL AGN hosts are associated with SMBHs residing in high-density pseudo-bulges and appear to overlap most significantly with the population of low-ionization nuclear emission-line region galaxies. As such, CL AGNs are likely fueled by strong episodic bursts of accretion activity, which appear to take place preferentially as the amount of material accessible for star formation and accretion dwindles. We also identify that CL AGN hosts are characterized by either large Sérsic indices or high bulge fractions, which suggests a simple metric for identifying candidates for spectroscopic follow-up observations in forthcoming synoptic surveys.