bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reflections on How Tinnitus Impacts the Lives of Children and Adolescents
Authors: Tegg-Quinn Susan , Eikelboom Robert H. , Brennan-Jones Christopher G. , Barabash Syndon , Mulders Wilhelmina H. A. M. , Bennett Rebecca J. 
Published: June 2021

Objectives
The aim of this study was to generate a conceptual framework describing which aspects of children and adolescents' lives are affected by chronic tinnitus.

Design
Views and experiences of 32 participants from two participant groups informed this study: (a) a tinnitus group, consisting of adults who had experienced tinnitus during childhood and/or adolescence and primary carers of children/adolescents with tinnitus, and (b) a clinicians' group, consisting of clinicians who provided care for children/adolescents with tinnitus. Participants produced statements describing aspects of children/adolescents' lives that may be affected by chronic tinnitus. Key concepts were identified through the processes of sorting the statements and rating them for degree of associated impact.

Result
Participants identified 118 unique aspects of the lives of children/adolescents who may be affected by chronic tinnitus. These were clustered into four concepts: (a) emotional well-being, (b) academic performances, (c) social/relationa, and (d) auditory/cognitive processing. At a group level, participants rated the impact of tinnitus as above a slight degree but below a moderate degree of impact. However, individual participant's ratings indicated a range of perceived impact for each statement.

Conclusions
The experience of chronic tinnitus during childhood and adolescence extends beyond the mere perception of sound. The perception of tinnitus may impact a child's emotional well-being, academic performances, social/relational, and auditory/cognitive processing. The impact of tinnitus in one aspect of a child's life may influence other aspects of their life. While at a group level, participants regarded the impact of tinnitus as “somewhat more than mild” to “less than moderate”; individual participant's ratings indicate that the impact from chronic tinnitus may be highly individual and highlighted the importance of individual assessment and management. Clinically, tinnitus management during childhood and adolescence may be improved if clinicians consider the impact and manifestation of tinnitus within each child's daily life and tailor tinnitus education and management strategies accordingly.
Resilience as a Mainstream Clinical Consideration for Speech-Language Pathologists Providing Post–Acquired Brain Injury Neurorehabilitation
Authors: Rothbart Aaron , Sohlberg McKay Moore 
Published: June 2021

PurposeWhile resilience is seen as fundamental to recovery and rehabilitation processes within the psychology discipline, (Bonanno, 2004), it has received little acknowledgement throughout speech pathology literature. Research suggests that targeting the malleable components associated with the recruitment and development of resilience has the potential to optimize acquired brain injury (ABI) rehabilitation outcomes. This article examines key constructs fundamental to understanding resilience and provides examples of existing evidence-based practices that can be feasibly incorporated into existing neurorehabilitation practices to drive the establishment of resilience.MethodArticles describing resilience models and frameworks were examined to identify resilience factors that could be fostered during neurorehabilitation therapy sessions.ResultsThe literature supports a series of common traits across resilience intervention models that enhance the development of resilience including the promotion of optimism, motivation, self-efficacy, and interpersonal connectedness. We describe a number of established communication strategies and counseling techniques that promote these resilience factors and can be integrated into rehabilitation therapy sessions.ConclusionsSpeech pathologists should consider resilience as a primary and essential clinical ingredient in their rehabilitation interventions. It is important that clinicians are trained in the communication and counseling skills that comprise these ingredients. Bolstering resilience while addressing rehabilitation targets can optimize clinical outcomes.
Development of a three‐phase interleaved converter based on SEPIC DC–DC converter operating in discontinuous conduction mode for ultra‐fast electric vehicle charging stations
Authors: Hussein Bayan , Abdi Nima , Massoud Ahmed 
Published: June 2021

AbstractOne of the main challenges that impact transportation systems electrification is their batteries' charging process. This work presents the development of a three‐phase ultra‐fast Electric Vehicle (EV) charger based on the SEPIC converter. Since SEPIC operating in Discontinuous Conduction Mode (DCM) is usually recommended for low‐power applications, this work proposes a scheme for its employment in high‐power EV chargers. This is achieved through three single‐phase modules of interleaved SEPIC converters. The presented scheme ensures reducing the stresses on the semiconductor devices since the power is divided over the interleaved modules. The design addresses DCM operation in terms of both capacitor voltage and inductor current (DCVM and DICM, respectively). This paper examines the analysis of the proposed converter and the small‐signal modelling. Also, the converter efficiency is assessed. A Constant Current (CC) charging approach is deployed for charging the EV battery. The validation of the designs is explored through simulation results using MATLAB/Simulink platform. A 4 kW experimental prototype for the interleaved SEPIC DC–DC converter is built to verify the claimed contributions with 92% efficiency.
AMICO galaxy clusters in KiDS-DR3
Authors: Giocoli Carlo , Marulli Federico , Moscardini Lauro , Sereno Mauro , Veropalumbo Alfonso , Gigante Lorenzo , Maturi Matteo , Radovich Mario , Bellagamba Fabio , Roncarelli Mauro , Bardelli Sandro , Contarini Sofia , Covone Giovanni , Harnois-Déraps Joachim , Ingoglia Lorenzo , Lesci Giorgio F. , Nanni Lorenza , Puddu Emanuella 
Published: June 2021

Context. The large-scale mass distribution around dark matter haloes hosting galaxy clusters provides sensitive cosmological information.
Aims. In this work we make use of a large photometric galaxy cluster sample, constructed from the public Third Data Release of the Kilo-Degree Survey, and the corresponding shear signal, to assess cluster masses and test the concordance Λ-cold dark matter (ΛCDM) model. In particular, we study the weak gravitational lensing effects on scales beyond the cluster virial radius, where the signal is dominated by correlated and uncorrelated matter density distributions along the line of sight. The analysed catalogue consists of 6962 galaxy clusters, in the redshift range 0.1 ≤ z ≤ 0.6 and with signal-to-noise ratios higher than 3.5.
Methods. We perform a full Bayesian analysis to model the stacked shear profiles of these clusters. The adopted likelihood function considers both the small-scale one-halo term, used primarily to constrain the cluster structural properties, and the two-halo term, that can be used to constrain cosmological parameters.
Results. We find that the adopted modelling is successful in assessing both the cluster masses and the total matter density parameter, ΩM, when fitting shear profiles up to the largest available scales of 35 Mpc h−1. Moreover, our results provide a strong observational evidence of the two-halo signal in the stacked gravitational lensing of galaxy clusters, further demonstrating the reliability of this probe for cosmological studies. The main result of this work is a robust constraint on ΩM, assuming a flat ΛCDM cosmology. We get ΩM = 0.29 ± 0.02, estimated from the full posterior probability distribution, consistent with the estimates from cosmic microwave background experiments.
The CARMENES search for exoplanets around M dwarfs
Authors: Baroch D. , Morales J. C. , Ribas I. , Béjar V. J. S. , Reffert S. , Cardona Guillén C. , Reiners A. , Caballero J. A. , Quirrenbach A. , Amado P. J. , Anglada-Escudé G. , Colomé J. , Cortés-Contreras M. , Dreizler S. , Galadí-Enríquez D. , Hatzes A. P. , Jeffers S. V. , Henning Th. , Herrero E. , Kaminski A. , Kürster M. , Lafarga M. , Lodieu N. , López-González M. J. , Montes D. , Pallé E. , Perger M. , Pollacco D. , Rodríguez-López C. , Rodríguez E. , Rosich A. , Schöfer P. , Schweitzer A. , Shan Y. , Tal-Or L. , Zechmeister M. 
Published: June 2021

Context. M dwarfs are ideal targets for the search of Earth-size planets in the habitable zone using the radial velocity method, and are attracting the attention of many ongoing surveys. One of the expected results of these surveys is that new multiple-star systems have also been found. This is the case also for the CARMENES survey, thanks to which nine new double-line spectroscopic binary systems have already been announced.
Aims. Throughout the five years of the survey the accumulation of new observations has resulted in the detection of several new multiple-stellar systems with long periods and low radial-velocity amplitudes. Here we newly characterise the spectroscopic orbits and constrain the masses of eight systems and update the properties of a system that we had reported earlier.
Methods. We derived the radial velocities of the stars using two-dimensional cross-correlation techniques and template matching. The measurements were modelled to determine the orbital parameters of the systems. We combined CARMENES spectroscopic observations with archival high-resolution spectra from other instruments to increase the time span of the observations and improve our analysis. When available, we also added archival photometric, astrometric, and adaptive optics imaging data to constrain the rotation periods and absolute masses of the components.
Results. We determined the spectroscopic orbits of nine multiple systems, eight of which are presented for the first time. The sample is composed of five single-line binaries, two double-line binaries, and two triple-line spectroscopic triple systems. The companions of two of the single-line binaries, GJ 3626 and GJ 912, have minimum masses below the stellar boundary, and thus could be brown dwarfs. We found a new white dwarf in a close binary orbit around the M star GJ 207.1, located at a distance of 15.79 pc. From a global fit to radial velocities and astrometric measurements, we were able to determine the absolute masses of the components of GJ 282 C, which is one of the youngest systems with measured dynamical masses.
Angeborene Lungenfehlbildungen
Authors: Mayer Steffi , Gräfe Daniel , Wolfgang Hirsch Franz , Stepan Holger , Thome Ulrich , Lacher Martin 
Published: June 2021

ZUSAMMENFASSUNGZu den angeborenen Lungenfehlbildungen gehören neben den häufigen kongenitalen pulmonalen Atemwegsmalformationen (CPAM), bronchopulmonale Sequester (BPS), kongenitale lobäre Emphyseme (CLE) und bronchogene Zysten. Meist liegen isolierte Befunde vor. Mehr als 75 % der Kinder werden pränatal diagnostiziert. Anhand von Lokalisation und Gefäßversorgung in der Bildgebung sowie des prä- bzw. postnatalen Verlaufs werden die Eltern beraten. Gemeinsam ist den Lungenfehlbildungen eine Begünstigung bronchopulmonaler Infekte. Auch maligne Entartungen sind beschrieben, ein Kausalzusammenhang ist bisher nicht hinreichend belegt. Selten zeigen die Kinder schwere prä- bzw. postnatale Verläufe, die einer akuten Therapie bedürfen. Ansonsten erfolgt um den 3. Lebensmonat bzw. nach Diagnosestellung eine Schnittbildgebung. Hier gewinnt das Thorax-MRT zunehmend an Bedeutung. Spontanregressionen sind selten (< 10 %). Symptomatische Läsionen werden thorakoskopisch oder offen chirurgisch entfernt. Bei asymptomatischen Läsionen müssen die Risiken rezidivierender Infektionen sowie einer malignen Entartung gegen Komplikationen einer OP abgewogen werden. Die Langzeitprognose ist bei adäquater Behandlung gut, die Lungenfunktion in der Mehrzahl der Fälle unbeeinträchtigt.
Applying basic principles of surgery may pave the way for more effective endoscopic bariatric techniques
Authors: Hashiba Kiyoshi , Cappellanes Carlos Alberto , de Siqueira Pablo Rodrigo , Conrado Antonio Carlos , Ribeiro Bruno , Marson Fernando Pavinato , Pedron Bruno Gregnanin 
Published: June 2021

Abstract
Background and study aims In the last decade, gastroenterologists have been attempting to use endoscopy to reproduce the great success of traditional surgical suture techniques. Despite recent advances, we still lack a reliable method that results in a permanent suture with minimal incidence of suture failure. This was an experimental study in pigs with an innovative technique that applied basic surgical concepts to endoscopy to evaluate the effectiveness of a novel suture technique.
Methods The procedures were performed on six live pigs under general anesthesia. Endoscopic mucosal resection (EMR) first was performed in the stomach, exposing the submucosal or muscularis propria layers. A novel device, a transparent chamber cap (DASE), was developed to aspirate the gastric wall, allowing the sutures to reach deep layers. The aspiration was performed with a standard gastroscope to which the novel cap was distally attached. Three sutures aligned were defined as a plication. Each pig received two or three plications and was placed on a liquid diet for 14 days after the procedure. The pigs were sacrificed at 4 and 8 weeks and the sutures were reviewed.
Results The technique was feasible in all animals. Of 16 plications, only one failed. One perforation occurred after EMR. There were no other complications or adverse events. Permanent fusion of the gastric wall was confirmed by histology in all cases.
Conclusions This study showed that basic principles of surgery can be applied endoscopically to ensure a permanent suture with reduced chances of failure. These findings can help to pave the way for more effective bariatric endoscopic techniques.
Underutilization of prophylactic rectal indomethacin and pancreatic duct stent for prevention of post-ERCP Pancreatitis
Authors: Issak Abdulfatah , Elangovan Abbinaya , Ferguson Roy D. , Waghray Nisheet , Sandhu Dalbir S. 
Published: June 2021

Abstract
Background and study aims Incidence of Post-ERCP pancreatitis (PEP) ranges from 1 % to 10 % in unselected patients and as high as 25 % to 30 % in high-risk patients. Rectal indomethacin administered before or immediately after an ERCP and prophylactic pancreatic duct stent placement (PPS) are associated with a reduction in the incidence of PEP. We sought to investigate the utilization rate for prophylactic rectal indomethacin and PPS in average and high-risk patients undergoing ERCP between 2014 and 2019.
Patients and methods We performed a retrospective analysis in the IBM Explorys database, a pooled, national de-identified clinical database of over 72 million unique patients from 26 health care networks and 300 hospitals across the United States from 2014 to 2019. Average and high-risk patients undergoing ERCP were identified using Systematized Nomenclature of Medicine Clinical Terms (SNOMED CT) diagnosis codes. PEP was defined by the presence of SNOMED CT diagnosis of acute pancreatitis and an inpatient admission within 5 days of an ERCP procedure.
Results Out of 31,050 adults who had undergone ERCP from 2014 to 2019, only 10,500 individuals (33.8 %) had a PEP prophylaxis. Rectal indomethacin and PPS accounted for 82.4 % and 12.9 % respectively. Individuals with three risk factors had the highest PEP rates followed by individuals with two risk factors.
Conclusions Only one-third of all patients undergoing ERCP received prophylaxis in the form of rectal indothemacin and/or PPS in this large population-based data. Increased implementation of prophylactic use is needed in patients undergoing ERCP as supported by current guidelines.
Epilepsien im Säuglingsalter
Authors: Chemnitzer Olga , Gburek-Augustat Janina , Bernhard Matthias K. 
Published: June 2021

ZUSAMMENFASSUNGEpilepsien im Säuglingsalter sind häufig, es kommen sowohl strukturell-metabolische, genetische als auch unklare Epilepsien infrage. Bei einem reichlichen Drittel der Säuglinge mit einer Epilepsie liegt eine epileptische Enzephalopathie, meist mit zusätzlichen Entwicklungsauffälligkeiten zugrunde. Hierzu gehören u. a. das West-Syndrom mit Blitz-Nick-Salaam-Anfällen und einer Hypsarrhthmie im EEG, das Dravet-Syndrom mit Anfällen, welche nicht selten durch Erhöhung der Körpertemperatur getriggert werden und das Ohtahara-Syndrom mit sehr früher Manifestation, Burst-Suppression-Muster im EEG und ungünstiger Prognose. Im klinischen und elektrophysiologischen Bild ähnlich, aber hiervon differerenzialdiagnostisch abzugrenzen sind Vitamin-B6-abhängige Epilepsien, welche unter Substitution mit Pyridoxalphosphat rasch sistieren. Auch Epilepsiesyndrome mit günstiger Prognose wie die benigne infantile Partialepilepsie (Watanabe) mit spontanem Sistieren der Anfälle nach einigen Monaten kommen vor.Sollte die stufenweise Diagnostik keine Hinweise auf das Vorliegen zerebraler Krampfanfälle ergeben, können differenzialdiagnostisch auch nicht-epileptische Anfälle infrage kommen.
Eczematous Lesion of Nipple and Areola Treated with Individualised Homoeopathic Treatment
Authors: Roy Poulamy Singha , Hazra Anupam , Goswami Pritam 
Published: June 2021

AbstractBreast and nipple–areolar complex has its own functional, sexual and cosmetic values. The skin around nipple and areola is prone to develop several kinds of infections during different stages of life ranging from mild-to-moderate dermatitis to neoplastic growths. Lack of knowledge of the patients about breast hygiene and the spectrum of the breast diseases among medical practitioners renders prompt diagnosis; hence, it develops several complications from its own array. Apparently, an uncommon presentation of dermatitis sometimes causes several complications at different stages of life and mostly during the period of lactation where the newborn suffers as a consequence of mother's illness. In this case, a female patient approached our outpatient department with complaints of itching and burning of nipple and areola with occasional discharge, which was diagnosed as eczema of nipple and areola after clinical examination. Initially, we started our treatment with Sulphur 30 and from then patient showed gradual improvement. Within a period of 1 month, patient showed promising improvement and it took 2 more months to subside other residual complaints. This case report not only portrays effectiveness of individualised homeopathy but also focuses on the cost-effectiveness of homeopathic treatments.
Bioengineered Liver Models for Investigating Disease Pathogenesis and Regenerative Medicine
Authors: Kukla David A. , Khetani Salman R. 
Published: June 2021

AbstractOwing to species-specific differences in liver pathways, in vitro human liver models are utilized for elucidating mechanisms underlying disease pathogenesis, drug development, and regenerative medicine. To mitigate limitations with de-differentiated cultures, bioengineers have developed advanced techniques/platforms, including micropatterned cocultures, spheroids/organoids, bioprinting, and microfluidic devices, for perfusing cell cultures and liver slices. Such techniques improve mature functions and culture lifetime of primary and stem-cell human liver cells. Furthermore, bioengineered liver models display several features of liver diseases including infections with pathogens (e.g., malaria, hepatitis C/B viruses, Zika, dengue, yellow fever), alcoholic/nonalcoholic fatty liver disease, and cancer. Here, we discuss features of bioengineered human liver models, their uses for modeling aforementioned diseases, and how such models are being augmented/adapted for fabricating implantable human liver tissues for clinical therapy. Ultimately, continued advances in bioengineered human liver models have the potential to aid the development of novel, safe, and efficacious therapies for liver disease.
A Viskovatov algorithm for Hermite-Padé polynomials
Authors: Ikonomov N. R. , Suetin S. P. 
Published: June 2021

Abstract
We propose and justify an algorithm for producing Hermite- Padé polynomials of type I for an arbitrary tuple of

formal power series

,

, about the point

(

) under the assumption that the series have a certain (‘general position’) nondegeneracy property. This algorithm is a straightforward extension of the classical Viskovatov algorithm for constructing Padé polynomials (for

our algorithm coincides with the Viskovatov algorithm).
The algorithm is based on a recurrence relation and has the following feature: all the Hermite-Padé polynomials corresponding to the multi- indices

,

,

,

,

are already known at the point when the algorithm produces the Hermite-Padé polynomials corresponding to the multi- index

.
We show how the Hermite-Padé polynomials corresponding to different multi-indices can be found recursively via this algorithm by changing the initial conditions appropriately.
At every step

, the algorithm can be parallelized in

independent evaluations.
Bibliography: 30 titles.
Compressed vessels bias red blood cell partitioning at bifurcations in a hematocrit-dependent manner: Implications in tumor blood flow
Authors: Enjalbert Romain , Hardman David , Krüger Timm , Bernabeu Miguel O. 
Published: June 2021

Significance
In tumors, tissue oxygen heterogeneity leading to the appearance of hypoxic regions is linked to poor prognosis and reduces the efficiency of therapeutic treatment. Following previous reports that vessel compression, caused by the tumor, leads to tumor tissue oxygen heterogeneity, we formulate a computational model to investigate the mechanism whereby vessel compression affects tissue oxygenation. Our results show that compressed vessels lead to an abnormal partitioning of red blood cells at vascular bifurcations and therefore heterogeneity in oxygen transport to tissue. This work uncovers a biomechanical causal link between vessel compression and tumor tissue oxygen heterogeneity, furthering our understanding of the tumor microenvironment and contributing to an emergent theory of biotransport in tumors that can underpin future therapeutic approaches.
The effect of parathyroid hormone on osteogenesis is mediated partly by osteolectin
Authors: Zhang Jingzhu , Cohen Adi , Shen Bo , Du Liming , Tasdogan Alpaslan , Zhao Zhiyu , Shane Elizabeth J. , Morrison Sean J. 
Published: June 2021

Significance
Only recently have multiple, anabolic, bone-forming agents become available, raising the possibility that osteoporosis might be more effectively treated by combinatorial or sequential treatments rather than single agents. The discovery of osteolectin raised two important questions in this regard. First, what is the epistatic relationship between these agents? Second, would osteolectin have additive effects if combined with another agent? Our discovery that osteolectin mediates part of the effect of parathyroid hormone (PTH) on bone formation identifies a new mechanism by which PTH acts. The observation that PTH and osteolectin have additive effects provides proof-of-principle that combinatorial use can increase osteogenesis.