bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maximizing design potential: investigating the effects of utilizing opportunistic and restrictive design for additive manufacturing in rapid response solutions
Authors: Prabhu Rohan , Masia Jordan Scott , Berthel Joseph T. , Meisel Nicholas Alexander , Simpson Timothy W. 
Published: June 2021

Purpose
The COVID-19 pandemic has resulted in numerous innovative engineering design solutions, several of which leverage the rapid prototyping and manufacturing capabilities of additive manufacturing. This paper aims to study a subset of these solutions for their utilization of design for AM (DfAM) techniques and investigate the effects of DfAM utilization on the creativity and manufacturing efficiency of these solutions.

Design/methodology/approach
This study compiled 26 COVID-19-related solutions designed for AM spanning three categories: (1) face shields (N = 6), (2) face masks (N = 12) and (3) hands-free door openers (N = 8). These solutions were assessed for (1) DfAM utilization, (2) manufacturing efficiency and (3) creativity. The relationships between these assessments were then computed using generalized linear models to investigate the influence of DfAM utilization on manufacturing efficiency and creativity.

Findings
It is observed that (1) unique and original designs scored lower in their AM suitability, (2) solutions with higher complexity scored higher on usefulness and overall creativity and (3) solutions with higher complexity had higher build cost, build time and material usage. These findings highlight the need to account for both opportunistic and restrictive DfAM when evaluating solutions designed for AM. Balancing the two DfAM perspectives can support the development of solutions that are creative and consume fewer build resources.

Originality/value
DfAM evaluation tools primarily focus on AM limitations to help designers avoid build failures. This paper proposes the need to assess designs for both, their opportunistic and restrictive DfAM utilization to appropriately assess the manufacturing efficiency of designs and to realize the creative potential of adopting AM.
Good governance matters for well-being: the case of Kazakhstan
Authors: Serikbayeva Balzhan , Abdulla Kanat 
Published: June 2021

Purpose
This paper aims to investigate the impact of the perceived performance of the government on subjective well-being based on the individual-level survey data of Kazakhstan. Having implemented substantial economic and public administration reforms over nearly three decades since independence in 1991 Kazakhstan presents an interesting case to explore how people perceive the outcomes of the reforms.

Design/methodology/approach
This paper estimates the relationship between life satisfaction and its determinants with the ordered logit model making use of the ranking information in the response variable.

Findings
This paper establishes that satisfaction with public service delivery, living conditions and personal and economic factors that are subject to public policy, along with trust in government institutions contribute to life satisfaction. The more satisfied individuals are with the quality, affordability and accessibility of public services, the more satisfied they are with their lives as a whole. A higher level of trust in government institutions increases individual well-being.

Originality/value
There is still a lack of research on subjective well-being in the less developed world. This study will help reveal important determinants of subjective well-being in the context of a developing country. Also, this study is valuable in terms of examining the impact of citizen satisfaction with public service delivery on subjective wellbeing based on rich individual-level data of the national quality of life (QoL) survey.
Social disruption of the tourism and hospitality industries: implications for post-COVID-19 pandemic recovery
Authors: Chapman Connor M. , Miller DeMond Shondell , Salley Geremy 
Published: June 2021

PurposeThe purpose of this study is to examine how societal disruptions in the wake of disasters and crises also disrupt the tourism and hospitality industries.Design/methodology/approachThis paper takes a case-study approach. First, the literature on disasters/crises is reviewed; then three cases in which disasters impacted local, regional and global tourism and hospitality industries are examined: Hurricane Katrina, Arab Spring and the COVID-19 pandemic.FindingsThree principles are proposed to assist in mitigating the impacts of disaster on the tourist industry. These principles also serve as a means of potentially re-orienting and guiding the tourism and hospitality industries toward a sustainable and equitable future.Originality/valueIn addition to the three guiding principles offered in this paper; the examination of COVID-19 offers a novel case in which tourism is impacted globally by a singular disaster. Findings and implications from this case will guide recovery and, potentially, allow for a reconceptualization of the tourism and hospitality industries.
Possible role of epiregulin from dermal fibroblasts in the keratinocyte hyperproliferation of psoriasis
Authors: Iwata Hiroaki , Haga Naoya , Ujiie Hideyuki 
Published: June 2021

AbstractPsoriasis, an immune‐mediated inflammatory disease, is characterized by keratinocyte hyperproliferation. Tumor necrosis factor (TNF)‐α, interleukin (IL)‐23, and IL‐17A play critical roles in the pathogenesis of psoriasis. IL‐17A secreted by T‐helper 17 acts more directly against keratinocytes than TNF‐α or IL‐23 do. Regarding the receptors of cytokines, fibroblasts also express receptors against IL‐17A and TNF‐α, and induce the production of growth factors. Epiregulin (EREG), an epidermal growth factor receptor ligand, is produced by both keratinocytes and fibroblasts. EREG enhances keratinocyte proliferation and differentiation. We hypothesized that fibroblasts stimulated with IL‐17A and/or TNF‐α may play a role in epidermal hyperproliferation through the production of epidermal growth factors in psoriasis. The mRNA expression of EREG was found to be significantly upregulated by co‐stimulation with IL‐17A and TNF‐α (mean, 49.2‐fold). Furthermore, the stimulation with TNF‐α alone, but not IL‐17A alone, induced significant increases. Immunofluorescent staining demonstrated that the protein expression level of EREG was also increased in fibroblasts stimulated with these cytokines. Stimulation with EREG significantly enhanced keratinocyte proliferation in vitro. In human psoriatic patients’ skin, immunofluorescence staining of EREG showed significantly high intensity in the dermis of lesional skin. In conclusion, cytokine stimulation with TNF‐α and IL‐17A induces the overexpression of EREG from dermal fibroblasts in the lesional skin of psoriasis, and plays a role in epidermal hyperproliferation.
Investigation of patterns and dynamics of substance users: A long‐term toxicology study on a sample of the Greek population between 2005 and 2019
Authors: Karakasi Maria‐Valeria , Kevrekidis Dimitrios‐Phaedon , Voultsos Polichronis , Trypsiannis Grigorios , Manolopoulos Vangelis G. , Raikos Nikolaos , Pavlidis Pavlos 
Published: June 2021

AbstractThe purpose of the present study is to investigate dynamics underlying drug abuse and identify statistical correlations/patterns of forensic findings and sociodemographic factors in a population of illicit substance users. The following long‐term studies were conducted: (a) a retrospective autopsy cohort study on autopsy incidents with available toxicological screening results (N = 482) in investigation of any possible forensic associations of exposure to illicit drugs; and (b) a cross‐sectional study on a sample of arrested drug law offenders with available toxicological screening results (N = 195) as well as cluster analysis in order to possibly identify user profiles. Although outside the scope of the present study, ethanol was generally considered to be the main substance of abuse, as more than half of the premature deaths reported tested positive on the ethanol toxicology screen. Cannabis and opioid use was associated with unintentional causes of death, while an association of deliberate self‐harm was noted with opioid and benzodiazepine use. Both cannabis and opioid use correlated with significantly younger ages (more than a decade) of premature death. Most frequently, an onset of substance use was reported in the early 20s with cannabis use. Although 65.3% of the subjects were diagnosed as dependent and unable to eliminate substance use on their own, only 7.7% of the subjects in the users’ population had ever accessed appropriate support through rehabilitation programs.
Improving dialysis adequacy and quality of life in patients undergoing hemodialysis with twice a week range of motion exercise
Authors: Rochmawati Erna , Utomo Endrat Kartiko , Makiyah Sri Nabawati Nurul 
Published: June 2021

AbstractThe study aimed to determine the effects of giving range of motion (ROM) twice a week as a form intradialytic exercise on patients' dialysis adequacy and quality of life. A total of 48 eligible participants were recruited and completed this study. The intervention group (n = 24) received twice a week ROM exercise over a 4 weeks period. The outcomes were assessed at pretest and at the end of the intervention. The study shows that ROM exercise was effective in improving dialyis adequacy that include ureum retention ratio (p= 0.027) and Kt/V (p= 0.017). Quality of life improved significantly particularly in the domains of symptom and effect of kidney disease. Integrating ROM into dialysis care shows as a potential intervention to improve dialysis adequacy and quality of life for patients undergoing hemodialysis. Future research should evaluate its efficacy using a randomized clinical trial design and larger sample of patients.
Mothers on Mute: A Silent Pandemic
Authors: Griffith Lauren Miller 
Published: June 2021

SummaryMy experience of the COVID‐19 pandemic, and trying to write through it, has been profoundly shaped by my identity as a mother. Like me, many women—mothers in particular—have had their voices muted by the demands of domestic labor. Trying to find a way to continue telling the stories that matter to me during these times has made me see how important it is for mothers to unmute and claim a space for our voices, even if our voices must change in order to be heard.
Thromboinflammation in coronavirus disease 2019: The clot thickens
Authors: Iffah Raayma , Gavins Felicity N. E. 
Published: June 2021

Since the start of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic, a disease that has become one of the world's greatest global health challenges, the role of the immune system has been at the forefront of scientific studies. The pathophysiology of coronavirus disease 2019 (COVID‐19) is complex, which is evident in those at higher risk for poor outcome. Multiple systems contribute to thrombosis and inflammation seen in COVID‐19 patients, including neutrophil and platelet activation, and endothelial dysfunction. Understanding how the immune system functions in different patient cohorts (particularly given recent emerging events with the Oxford/AstraZeneca vaccine) is vital to understanding the pathophysiology of this devastating disease and for the subsequent development of novel therapeutic targets and to facilitate possible drug repurposing strategies that could benefit society on a global scale.LINKED ARTICLESThis article is part of a themed issue on The second wave: are we any closer to efficacious pharmacotherapy for COVID 19? (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.10/issuetoc
Geographic variation in Culex oviposition habitat selection responses to a predator, Notonecta irrorata
Authors: Pintar Matthew R. , Bohenek Jason R. , Resetarits William J. 
Published: June 2021

1. Predators have effects on prey populations through both consumptive and non‐consumptive effects. Predator's presence is expected to drive variation in prey oviposition habitat selection behaviour, but differences in biotic and abiotic characteristics of habitats, or trait variation, may produce geographic variation in species interactions.2. We conducted a series of experiments in two geographic locations, Mississippi and Missouri, USA, to assess oviposition responses of Culex mosquitoes (prey) to the presence of Notonecta irrorata (predator). We first tested whether mosquitoes in each location respond to the presence of N. irrorata, with follow‐up experiments to determine whether mosquitoes respond to variation in N. irrorata density, whether N. irrorata from each location generate different responses by the same Culex population, and whether diet and consumption of conspecifics affect oviposition.3. We found that Culex restuans in Missouri had reduced oviposition when N. irrorata were present. In Mississippi, C. restuans did not respond to the presence of N. irrorata from either Mississippi or Missouri, to the variation in density of N. irrorata, or to N. irrorata that had been fed larval mosquitoes.4. Our study documents the first instance of geographic variation in oviposition response of a prey species to a predator species.
Wariness to colour patterns: birds versus European red‐and‐black insects
Authors: Soukupová Tereza , Veselý Petr , Fuchs Roman 
Published: June 2021

1. A mimetic complex of red‐and‐black insects is proposed to occur in Central Europe.2. In our study, we tested in isolation the importance of a colour pattern as the main factor responsible for the predator avoidance of the members of this putative mimetic complex by transferring the patterns of seven European red‐and‐black insects onto a palatable prey using paper stickers. Wild‐caught adult great tits (Parus major) were used as the predators.3. In general, the response of the tested birds to palatable prey carrying a conspicuous pattern differed from their responses to the real insect species demonstrated in previous studies.4. The birds avoided the pattern of Pyrrhocoris apterus most often, putatively because of their rich individual experience with the real insect from the wild, since it is the most common amongst our chosen species. Other patterns were attacked similarly to the control, inconspicuous roach pattern. Obviously, these patterns did not discourage the birds from making a closer inspection of the offered prey and revealing the edible cockroach hidden underneath the coloured paper sticker.5. We show that the method of transferring aposematic colour patterns to edible prey has substantial limitations when testing how predators generalise colour patterns within the mimetic complex.
Retrospective study of treatment patterns and outcomes post‐lenalidomide for multiple myeloma in Canada
Authors: Reece Donna E. , Masih‐Khan Esther , Atenafu Ehetu G. , Jimenez‐Zepeda Victor H. , McCurdy Arleigh , Song Kevin , LeBlanc Richard , Sebag Michael , White Darrell , Cherniawsky Hannah , Reiman Anthony , Stakiw Julie , Louzada Martha L. , Kotb Rami , Aslam Muhammad , Gul Engin , Venner Christopher P. 
Published: June 2021

AbstractLenalidomide is an important component of initial therapy in newly diagnosed multiple myeloma, either as maintenance therapy post‐autologous stem cell transplantation (ASCT) or as first‐line therapy with dexamethasone for patients’ ineligible for ASCT (non‐ASCT). This retrospective study investigated treatment patterns and outcomes for ASCT‐eligible and ‐ineligible patients who relapsed after lenalidomide as part of first‐line therapy, based on data from the Canadian Myeloma Research Group Database for patients treated between January 2007 and April 2019. Among 256 patients who progressed on lenalidomide maintenance therapy, 28.5% received further immunomodulatory derivative‐based (IMiD‐based) therapy (lenalidomide/pomalidomide) without a proteasome inhibitor (PI) (bortezomib/carfilzomib/ixazomib), 26.2% received PI‐based therapy without an IMiD, 19.5% received both an IMiD plus PI, 13.5% received daratumumab‐based regimens, and 12.1% underwent salvage ASCT. Median progression‐free survival (PFS) was longest for daratumumab‐based therapy (22.7 months) and salvage ASCT (23.4 months) and ranged from 6.6 to 7.3 months for the other treatments (P < .0001). Median overall survival (OS) was also longest for daratumumab and salvage ASCT. A total of 87 non‐ASCT patients received subsequent therapy, with 66.7% receiving bortezomib‐based therapy and 13.8% receiving other PI‐based therapy. Median PFS was 15.4 and 24.8 months for bortezomib‐based and other PI‐based therapy, respectively (P = .404). During most of the study period, daratumumab was not funded; in this setting, switching to a different therapeutic class following relapse on lenalidomide produced the longest remissions for non‐ASCT patients. Further prospective studies are warranted to determine optimum treatment following relapse on lenalidomide, especially in the light of increased access to daratumumab.
Use of the MODFLOW 6 Water Mover Package to Represent Natural and Managed Hydrologic Connections
Authors: Morway Eric D. , Langevin Christian D. , Hughes Joseph D. 
Published: June 2021

AbstractThe latest release of MODFLOW 6, the current core version of the MODFLOW groundwater modeling software, debuted a new package dubbed the “mover” (MVR). Using a generalized approach, MVR facilitates the transfer of water among any arbitrary combination of simulated features (i.e., pumping wells, stream, drains, lakes, etc.) within a MODFLOW 6 simulation. Four “rules” controlling the amount of water transferred from a providing feature to a receiving feature are currently available. In this way, MVR can represent natural connections between features, for example, streams entering or exiting lakes, and perhaps more interestingly, it also can transfer water among simulated features to more accurately simulate water management. An example model representative of an agricultural setting demonstrates some of the available MVR connections. For example, an irrigation event that transfers surface water from an irrigation delivery ditch to multiple cropped areas demonstrates a “one‐to‐many” connection that is possible within MVR. Conversely, irrigation or precipitation runoff from multiple fields may be routed to a particular stream segment using “many‐to‐one” MVR connections. MVR supports many additional connection types, several of which are demonstrated by the included example problem.
Evaluation of thermal resistance for metalized ceramic substrates using a microheater chip
Authors: Hirao Kiyoshi , Zhou You , Hyuga Hideki , Nagao Shijo , Suganuma Katsuaki , Wakasugi Naoki 
Published: June 2021

AbstractThermal dissipation performance is one of the key technologies in designing power modules because their output power and power density have been increasing year by year. Metalized ceramic substrates are generally used as an insulating material in high output power modules. Designing a proper module structure requires not only each material property but also understanding of the heat transfer in a module structure. An accurate measurement method of precise thermal properties for such metallized ceramic substrates is currently still missing. We had developed a new and simple measurement method for evaluating the heat releasing performance of metallized ceramic substrates in a mounted state. In this investigation, the thermal resistance of several kinds of Cu‐metalized ceramic substrates bearing an SiC microheater chip was evaluated. Si3N4 with thermal conductivity, k, of 90 W/(m·K), AlN with k of 180 W/(m·K), and Al2O3 with k of 30 W/(m·K) were employed. In all cases, the measured thermal resistance had an excellent accuracy within an error range of a few percent. In addition, it was revealed that the measured values had good agreement with the estimated values by finite element method (FEM) analyses.
Treatment for grade 4 peripheral intravenous infiltration with type 3 skin tears: A case report and literature review
Authors: Wang Jie , Li Man‐Man , Zhou Le‐Peng , Xie Ri‐Hua , Pakhale Smita , Krewski Daniel , Wen Shi Wu 
Published: June 2021

AbstractGrade 4 peripheral intravenous infiltration with skin tears has seldom been reported. On 4 August 2020, a 35‐year‐old female patient was admitted to the emergency department of our hospital because of postprandial abdominal pain for 2 hours. She was diagnosed with a severe acute pancreatitis with type II diabetes mellitus. On 7 August, a vein detained needle was inserted into the dorsal vein of her right foot to infuse drugs. On 9 August, a grade 4 infiltration, discoloured and bruised skin with a swollen area of 11 cm × 9 cm around the infusion part of her right foot, was discovered. The infusion was stopped immediately and the residual drug was aspirated at the infusion site. When removing the vein detained needle, the skin surrounding the infusion site on the right foot was torn by the adhesive dressing. The size of the skin tears was 6 cm × 3 cm (type 3). The patient was provided with appropriate dressing, manual lymphatic drainage, and surgical intervention. Two months later, she was fully recovered with no functional impairment of the affected foot. Timely local wound interventions could lead to a satisfactory outcome for severe peripheral intravenous infiltration with skin tears.
Systematic review: Incidence and prevalence of mucous membrane pressure injury in adults admitted to acute hospital settings
Authors: Fulbrook Paul , Lovegrove Josephine , Miles Sandra , Isaqi Ban 
Published: June 2021

AbstractMucous membrane pressure injury (MMPI) is associated with a history of medical device use at the site of injury. The current international guideline recommends they should be reported in incidence and prevalence studies. The aim of this systematic review was to analyse the incidence and prevalence of hospital‐acquired MMPI in adults admitted to acute hospital settings. Database searches (EBSCO CINAHL Complete, EBSCO Medline Complete, Embase, Scopus and Web of Science) were undertaken between October 2019 and February 2021, using search terms related to hospital‐acquired, mucosal and device‐related pressure injury/ulcer incidence and prevalence. Searches were limited to the English language. Articles published between 2008 and 2020, reporting incidence or prevalence of mucous membrane or medical device‐related pressure injury in non‐interventional samples were selected. Two authors assessed study bias and extracted data, with a third reviewer as arbitrator. Twenty‐one studies met inclusion criteria; most provided incidence data. No studies were found that specifically reported MMPI incidence or prevalence. It was possible to calculate incidence or prevalence from four studies; all were in intensive care settings. MMPI incidence of 0.8% and 30.4%, and prevalence of 1.7% and 3.7% were found. One study provided data that enabled calculation of prevalence of 0.1% in a non‐intensive care sample. Only one other study provided specific data about MMPI. It is concluded that there is insufficient evidence available to enable estimation of MMPI incidence or prevalence in either acute hospital or intensive care settings.