bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-Term Survival Outcomes and Treatment Experience of 64 Patients With Esthesioneuroblastoma
Authors: Zeng Qian , Tian Yifu , He Yihong , Xie Qiongxuan , Ou Ludi , Wang Min , Chen Wen , Wei Rui 
Published: March 2021

Background: Esthesioneuroblastoma (ENB) is a rare sinonasal malignancy, lacking a unified staging system and treatment. Management at a single center was retrospectively evaluated to inform future treatment options and prognostic factors.Methods: Clinical data of 64 consecutive ENB patients, including prognostic factors and treatment methods, were reviewed retrospectively. Data were collected to calculate overall survival (OS) and progression free survival (PFS).Results: The majority of tumors 84.4% were within Kadish C stage, 79.7% were within T3 or T4, and 64.0% were within Hyams grade III or IV. A total of 50 (78.1%) patients received surgery and combined radiotherapy with or without chemotherapy, 10 (15.6%) received surgery with or without chemotherapy alone, and 4 (6.3%) received radiotherapy with or without chemotherapy alone. The majority of patients (79.7%) underwent endoscopic resection (endoscopic and endoscopically assisted). Surgery combined with radiotherapy with or without chemotherapy resulted in significantly better OS (84.4 vs. 50.6%, 84.4 vs. 37.5%) compared to surgery alone and radiotherapy alone (P = 0.0064). Endoscopic surgery group (endoscopic and endoscopically assisted) resulted in significantly better 5-year PFS (61.7 vs. 22.2%) compared to the open surgery group (P &lt; 0.001). Although endoscopic surgery group was not a statistically significant predictor of 5-year OS (P = 0.54), the 5-year OS was 79.3% for the endoscopic surgery group and 76.2% for the open surgery group. A Cox regression analysis identified intracranial extension and surgery combined with radiotherapy as independent factors affecting 5-year OS while cervical lymph node metastasis and Hyams grade IV as independent factors affecting 5-year PFS.Conclusion: Our findings suggest that surgery combined with radiotherapy is the best treatment approach for ENB. For advanced tumors, endoscopic surgery is an effective treatment, and its survival rate is equal to or better than open surgery.
Clinical Value of ctDNA in Hematological Malignancies (Lymphomas, Multiple Myeloma, Myelodysplastic Syndrome, and Leukemia): A Meta-Analysis
Authors: Tan Xiangyu , Yan Han , Chen Lei , Zhang Yuyang , Sun Chunyan 
Published: March 2021

Background: Circulating tumor DNA (ctDNA) has offered a minimally invasive approach for the detection and measurement of cancer. However, its diagnostic and prognostic value in hematological malignancies remains unclear.Materials and methods: Pubmed, Embase, and Cochrane Library were searched for relating literature. Diagnostic accuracy variables and disease progression prediction data were pooled by the Meta-Disc version 1.4 software. Review Manager version 5.4 software was applied for prognostic data analysis.Results: A total of 11 studies met our inclusion criteria. In terms of diagnosis, the pooled sensitivity and specificity were 0.51 (95% confidence intervals (CI) 0.38–0.64) and 0.96 (95% CI 0.88–1.00), respectively. The AUSROC (area under the SROC) curve was 0.89 (95%CI 0.75–1.03). When it comes to the prediction of disease progression, the overall sensitivity and specificity was 0.83 (95% CI 0.67–0.94) and 0.98 (95% CI 0.93–1.00), respectively. Moreover, a significant association also existed between the presence of ctDNA and worse progression-free survival (HR 2.63, 95% CI 1.27–5.43, p = 0.009), as well as overall survival (HR 2.92, 95% CI 1.53–5.57, p = 0.001).Conclusions: The use of ctDNA in clinical practice for hematological malignancies is promising, as it may not only contribute to diagnosis, but could also predict the prognosis of patients so as to guide treatment. In the future, more studies are needed to realize the standardization of sequencing techniques and improve the detection sensitivity of exploration methods.
Clinical and Genetic Spectra of Inherited Liver Disease in Children in China
Authors: Fang Youhong , Yu Jindan , Lou Jingan , Peng Kerong , Zhao Hong , Chen Jie 
Published: March 2021

Background: Children presenting with chronic liver disease or acute liver failure often have an underlying genetic disorder. The aim of this study was to analyze the clinical and genetic spectra of inherited liver disease in children in a tertiary hospital.Methods: A total of 172 patients were classified into three groups according to their clinical presentation: cholestasis (Group A), liver enzyme elevation (Group B), and hepato/splenomegaly (Group C). Next-generation sequencing (NGS) was performed on all patients recruited in this study. The genotypic and phenotypic spectra of disease in these patients were reviewed.Results: The median age at enrollment of the 172 patients was 12.0 months (IQR: 4.9, 42.5 months), with 52.3% males and 47.7% females. The overall diagnostic rate was 55.8% (96/172) in this group. The diagnostic rates of whole-exome sequencing (WES) and targeted gene panel sequencing (TGPS) were 47.2% and 62.0%, respectively (no significant difference, p = 0.054). We identified 25 genes related to different phenotypes, including 46 novel disease-related pathogenic mutations. The diagnostic rates in the three groups were 46.0% (29/63), 48.6% (34/70), and 84.6% (33/39). ATP7B, SLC25A13, and G6PC were the top three genes related to monogenic liver disease in this study.Conclusion: WES and TGPS show similar diagnostic rates in the diagnosis of monogenic liver disease. NGS has an important role in the diagnosis of monogenetic liver disease and can provide more precise medical treatment and predict the prognosis of these diseases.
Mental Health Impacts in Argentinean College Students During COVID-19 Quarantine
Authors: López Steinmetz Lorena Cecilia , Leyes Candela Abigail , Dutto Florio María Agustina , Fong Shao Bing , López Steinmetz Romina Lucrecia , Godoy Juan Carlos 
Published: March 2021

Background:We aimed to: (1) analyze differences in both general (in terms of psychological well-being/discomfort, social functioning and coping, and psychological distress) and specific (depression, trait-anxiety, negative alcohol-related consequences, and suicidal risk) mental health state (MHS) in college students, residing in four different Argentinean regions (center, north, south, and the most populated) exposed to different spread-rates of the COVID-19; (2) analyze between-group differences in both general and specific MHS indicators at four quarantine sub-periods (twice prior, and twice following the first quarantine extension).Methods:We used a cross-sectional design with a convenience sample including 2,687 college students. Data was collected online during the Argentinean quarantine. We calculated one-way between-groups ANOVA with Tukey'spost hoctest.Results:Regionally, the center and the most populated area differed in psychological well-being/discomfort and negative alcohol-related consequences, but not in the remaining MHS indicators. According to the quarantine sub-periods, there were differences in psychological well-being/discomfort, social functioning and coping, psychological distress, and negative alcohol-related consequences. Negative alcohol-related consequences were the only MHS indicator improving over time. For all of the remaining MHS indicators, we found a similar deterioration pattern in the course of time, with mean scores decreasing from the first to the 2nd week of the quarantine pre-extensions, then increasing toward the 1st week of the quarantine post-extension (with some MHS indicators reaching mean scores worse than the start), and then continued to increase.Conclusion:A worsened mean MHS during quarantine suggests that quarantine and its extensions contribute to negative mental health impacts.
Benthic Flow and Mixing in a Shallow Shoal Grass (Halodule wrightii) Fringe
Authors: Cannon David , Kibler Kelly , Kitsikoudis Vasileios 
Published: March 2021

Mean flow and turbulence measurements collected in a shallow Halodule wrightii shoal grass fringe highlighted significant heterogeneity in hydrodynamic effects over relatively small spatial scales. Experiments were conducted within the vegetation canopy (~4 cm above bottom) for relatively sparse (40% cover) and dense (70% cover) vegetation, with reference measurements collected near the bed above bare sediment. Significant benthic velocity shear was observed at all sample locations, with canopy shear layers that penetrated nearly to the bed at both vegetated sites. Turbulent shear production (P) was balanced by turbulent kinetic energy dissipation (ϵ) at all sample locations (P/ϵ≈1), suggesting that stem-generated turbulence played a minor role in the overall turbulence budget. While the more sparsely vegetated sample site was associated with enhanced channel-to-shore velocity attenuation (71.4 ± 1.0%) relative to flows above bare sediment (51.7 ± 2.2%), unexpectedly strong cross-shore currents were observed nearshore in the dense canopy (VNS), with magnitudes that were nearly twice as large as those measured in the main channel (VCH; VNS/VCH¯ = 1.81 ± 0.08). These results highlight the importance of flow steering and acceleration for within- and across-canopy transport, especially at the scale of individual vegetation patches, with important implications for nutrient and sediment fluxes. Importantly, this work represents one of the first hydrodynamic studies of shoal grass fringes in shallow coastal estuaries, as well as one of the only reports of turbulent mixing within H. wrightii canopies.
Job Stress and Mental Well-Being among Working Men and Women in Europe: The Mediating Role of Social Support
Authors: Mensah Aziz 
Published: March 2021

Job stress is one of the most common health issues in many organizations, particularly among women. Moreover, an increase in job stress with low social support may have an adverse effect on mental well-being. This study investigated the mediating role of social support in the relationship between job stress and mental well-being among working men and women in Europe. A cross sectional data set from the 2015 6th European Working Conditions Survey on 14,603 men and 15,486 women from 35 countries in Europe was analyzed. The study applied Hayes process macro 4 modelling technique to estimate the direct, indirect, and total effects of job stress on mental well-being among working adults. The study further used the Hayes process macro 59 model to estimate the gender difference in the mediating effect. The results showed that job stress had a direct negative effect on mental well-being among workers in Europe (β=−0.2352,p<0.05). However, there were significant gender differences in the relationship (β=−0.3729,p<0.05), with women having higher effect size than men (men: β=−3.9129,p<0.05 vs. women: β=−4.2858,p<0.05). Furthermore, the indirect effect showed that social support mediated the relationship of job stress on mental well-being (β=−0.0181, CI: −0.0212−0.0153). Nevertheless, the mediating effect of social support did not differ among men and women. This study provides evidence that job stress has a negative impact on mental well-being among working adults, and social support mediates this relationship. The results highlight the importance of the role of support from colleagues and supervisors at the work place, which may help reduce job stress, and improve mental well-being. Sociological and occupational health researchers should not ignore the role of gender when studying work environment and jobs in general.
Model Residential School Education to Scheduled Caste Pupils in Kerala
Authors: Rejimon P M , Smitha R 
Published: March 2021

There are about forty lakh scheduled caste people in Kerala. Most of them are poor and daily wage workers. The socio-economic backwardness of scheduled caste people is a historically determined outcome of a caste system in India. Education is the only way for them to get out of this historical whirlwind of economic deprivation, denial of rights and social exclusion. The Government of India passed The Right to Education Act in 2010 and it ensures “free and compulsory education” for all children aged 6 to 14. The government of Kerala has introduced many innovative programs to provide education for scheduled caste pupils in the state. “Model Residential School” owned and managed by the Scheduled Caste Development Department of The Government of Kerala, is one of such successful initiatives. Model Residential Schools take special care to cater to the educational needs of the underprivileged children and help them to attain quality education. In this article, the investigators explore the role played by the model residential schools in the educational development of scheduled caste pupils in Kerala and particularly in solving the burning issue of a high rate of dropouts among scheduled caste pupils.
India’s Foreign Trade Under Plan Periods
Authors: Sajeev U , Akhila V P 
Published: March 2021

International Trade is an engine of growth of an economy. Trade is just not a transfer/exchange of goods and services, but it is more than it. So, when we date back to the history of trade, there we can see its been long back people started to travel and trade with various countries. Here, the study focuses on the India’s Trade during plan periods, especially under five year plan. Through this research work, it tries to study and evaluate the India’s foreign trade and its value, composition and direction.
Altitude dependent failure rate calculation for high power semiconductor devices in aviation electronics
Authors: Gollapudi Srikanth , Omura Ichiro 
Published: March 2021

Abstract
The electric power usage in aircraft has reached 1 MW. Therefore, use of high power semiconductor devices expected to increase in avionics. Single event burnout failure happens when power devices operating in blocking condition interact with the cosmic radiation. The failure rate in power devices is more in airplane altitude compare to terrestrial operation. In this paper, the failure rate of high power silicon PiN diode is evaluated when operating in airplane altitude due to the interaction of cosmic ray neutrons. The proposed formula has the unique feature of decoupling between failure cross section and cosmic ray neutron flux. This makes it possible to calculate the failure rate under any cosmic radiation environment using the proposed failure rate formulation.
Perspectives for the analysis of circulating tumor DNA in clinical oncology: achievements and unresolved issues
Authors: Yanus Grigory , Laidus Tatyana , Zagorodnev Kirill , Martianov Aleksandr , Sokolova Tatyana , Aleksakhina Svetlana , Kuligina Ekaterina , Imyanitov Evgeny 
Published: March 2021

The efforts to detect specific tumor-associated changes in blood and other biological fluids are by no means new. However, only the development of the most precise modifications of DNA analysis provided real opportunity to monitor tumor behavior in “real time” manner. Two directions should be distinguished within this field of modern oncology: 1) the early detection of cancer in apparently healthy individuals; 2) the use of liquid biopsy in patients with confirmed cancer diagnosis for a broad range of applications, such as the early diagnosis of recurrence or monitoring the treatment efficacy.
It should be stated, that the first direction of the research has not yet led to the results suitable for implementation in real world practice. Nevertheless, there are staggering technological advances in the analytical performance of NGS-based methods, which are applied to this task. The emerging non-standard approaches, involving the use of recently discovered peculiarities of the ctDNA fragmentation in plasma, or the complex approaches, utilizing a number of diverse methods simultaneously, are of great interest. The second, less ambitious direction of liquid biopsy studies is much closer to clinical use. This approach has already been widely used for such an actual issue, as the early non-invasive T790M detection in plasma of metastatic lung cancer patients, undergoing anti-EGFR therapy. Aside from the practical advances, the studies of various aspects of liquid biopsy provide all sorts of invaluable scientific information, for example regarding the precise timing patterns of the emergence of the resistance to anticancer drugs and the dynamics of its regression after changing of therapy regimen.
Effect of metformin on doxorubicin-induced cardiotoxicity in experiment
Authors: Ionov Stepan , Orlova Valentina , Kulbachevskaya Natalia 
Published: March 2021

The article provides an overview of the currently known descriptions of the mechanisms and toxic effects of two drugs: doxorubicin, a first-line drug for the treatment of cancer, and the mechanisms of action of Metformin, a drug widely used for the treatment of diabetes mellitus 2. The review made with the usage of NCBI, PubMed and OxfordAcademic presents the analysis of published data on the protective effect of Metformin in its combined use with doxorubicin in an experiment in an attempt to reduce the manifestations of doxorubicin-induced cardiotoxicity.
TIC 168789840: A Sextuply Eclipsing Sextuple Star System
Authors: Powell Brian P. , Kostov Veselin B. , Rappaport Saul A. , Borkovits Tamás , Zasche Petr , Tokovinin Andrei , Kruse Ethan , Latham David W. , Montet Benjamin T. , Jensen Eric L. N. , Jayaraman Rahul , Collins Karen A. , Mašek Martin , Hellier Coel , Evans Phil , Tan Thiam-Guan , Schlieder Joshua E. , Torres Guillermo , Smale Alan P. , Friedman Adam H. , Barclay Thomas , Gagliano Robert , Quintana Elisa V. , Jacobs Thomas L. , Gilbert Emily A. , Kristiansen Martti H. , Colón Knicole D. , LaCourse Daryll M. , Olmschenk Greg , Omohundro Mark , Schnittman Jeremy D. , Schwengeler Hans M. , Barry Richard K. , Terentev Ivan A. , Boyd Patricia , Schmitt Allan R. , Quinn Samuel N. , Vanderburg Andrew , Palle Enric , Armstrong James , Ricker George R. , Vanderspek Roland , Seager S. , Winn Joshua N. , Jenkins Jon M. , Caldwell Douglas A. , Wohler Bill , Shiao Bernie , Burke Christopher J. , Daylan Tansu , Villaseñor Joel 
Published: March 2021

Abstract
We report the discovery of a sextuply eclipsing sextuple star system from TESS data, TIC 168789840, also known as TYC 7037-89-1, the first known sextuple system consisting of three eclipsing binaries. The target was observed in Sectors 4 and 5 during Cycle 1, with lightcurves extracted from TESS Full Frame Image data. It was also previously observed by the WASP survey and ASAS-SN. The system consists of three gravitationally bound eclipsing binaries in a hierarchical structure of an inner quadruple system with an outer binary subsystem. Follow-up observations from several different observatories were conducted as a means of determining additional parameters. The system was resolved by speckle interferometry with a 0.″42 separation between the inner quadruple and outer binary, inferring an estimated outer period of ∼2 kyr. It was determined that the fainter of the two resolved components is an 8.217 day eclipsing binary, which orbits the inner quadruple that contains two eclipsing binaries with periods of 1.570 days and 1.306 days. Markov Chain Monte Carlo (MCMC) analysis of the stellar parameters has shown that the three binaries of TIC 168789840 are “triplets,” as each binary is quite similar to the others in terms of mass, radius, and T
eff. As a consequence of its rare composition, structure, and orientation, this object can provide important new insight into the formation, dynamics, and evolution of multiple star systems. Future observations could reveal if the intermediate and outer orbital planes are all aligned with the planes of the three inner eclipsing binaries.
The Diverse Molecular Gas Content of Massive Galaxies Undergoing Quenching at z ∼ 1
Authors: Belli Sirio , Contursi Alessandra , Genzel Reinhard , Tacconi Linda J. , Förster-Schreiber Natascha M. , Lutz Dieter , Combes Françoise , Neri Roberto , García-Burillo Santiago , Schuster Karl F. , Herrera-Camus Rodrigo , Tadaki Ken-ichi , Davies Rebecca L. , Davies Richard I. , Johnson Benjamin D. , Lee Minju M. , Leja Joel , Nelson Erica J. , Price Sedona H. , Shangguan Jinyi , Shimizu T. Taro , Tacchella Sandro , Übler Hannah 
Published: March 2021

Abstract
We present a detailed study of the molecular gas content and stellar population properties of three massive galaxies at 1 < z < 1.3 that are in different stages of quenching. The galaxies were selected to have quiescent optical/near-infrared spectral energy distribution and relatively bright emission at 24 μm, and show remarkably diverse properties. CO emission from each of the three galaxies is detected in deep NOEMA observations, allowing us to derive molecular gas fractions M
gas/M
* of 13%–23%. We also reconstruct the star formation histories by fitting models to the observed photometry and optical spectroscopy, finding evidence for recent rejuvenation in one object, slow quenching in another, and rapid quenching in the third system. To better constrain the quenching mechanism we explore the depletion times for our sample and other similar samples at z ∼ 0.7 from the literature. We find that the depletion times are highly dependent on the method adopted to measure the star formation rate: using the UV+IR luminosity we obtain depletion times about 6 times shorter than those derived using dust-corrected [O ii] emission. When adopting the star formation rates from spectral fitting, which are arguably more robust, we find that recently quenched galaxies and star-forming galaxies have similar depletion times, while older quiescent systems have longer depletion times. These results offer new, important constraints for physical models of galaxy quenching.
Update on the Brassicaceae species checklist
Authors: Francis Ardath , Lujan-Toro Beatriz , Warwick Suzanne , Macklin James , Martin Sara 
Published: March 2021

Here we present a revised species checklist for the Brassicaceae, updated from Warwick SI, Francis, A, Al-Shehbaz IA (2006), Brassicaceae: Species checklist and database on CD-ROM, Plant Systematics and Evolution 259: 249─25. This update of the checklist was initiated, based on recent taxonomic and molecular studies on the Brassicaceae that have resulted in new species names, combinations and associated synonyms.
New data have been added indicating tribal affiliations within the family and where type specimens have been designated. In addition, information from many early publications has been checked and added to the database. The database now includes information on 14983 taxa, 4636 of which are currently accepted and divided into 340 genera and 52 tribes. A selected bibliography of recent publications on the Brassicaceae is included.
Professeur-documentaliste
Authors: Lefeuvre Gwenaël , Grenier-Gire Chantal 
Published: March 2021

Ce texte a pour objectif de proposer un regard non exhaustif sur les recherches qui se sont intéressées au métier de professeur-documentaliste. Pour ce faire, cinq axes de questionnements ont été explorés : les finalités de ces recherches, leurs problématiques dominantes, les cadres théoriques mobilisés par les auteurs, les objets privilégiés puis les outils méthodologiques utilisés pour collecter et traiter les données empiriques. La synthèse proposée dans ce texte met en évidence la multi-référentialité des regards portés sur un métier complexe, composite et en développement.
Professeur-documentaliste
Authors: Sembel Nicolas 
Published: March 2021

L’objectif de ce chapitre est de préciser quel peut être l’apport d’une sociologie des professeurs-documentalistes. La démarche sociologique permet de « déspécifier » le métier et de « respécifier » le travail du professeur-documentaliste, dans un contexte de profession « dominée », d’inégalités face aux pratiques informationnelles, aux traitements documentaires, aux usages des biens culturels, et de possible circulation créative de ces biens.