bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of gout flare prophylaxis and therapy use in people with chronic kidney disease: a Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN)-initiated literature review
Authors: Pisaniello Huai Leng , Fisher Mark C. , Farquhar Hamish , Vargas-Santos Ana Beatriz , Hill Catherine L. , Stamp Lisa K. , Gaffo Angelo L. 
Published: April 2021

AbstractGout flare prophylaxis and therapy use in people with underlying chronic kidney disease (CKD) is challenging, given limited treatment options and risk of worsening renal function with inappropriate treatment dosing. This literature review aimed to describe the current literature on the efficacy and safety of gout flare prophylaxis and therapy use in people with CKD stages 3–5. A literature search via PubMed, the Cochrane Library, and EMBASE was performed from 1 January 1959 to 31 January 2018. Inclusion criteria were studies with people with gout and renal impairment (i.e. estimated glomerular filtration rate (eGFR) or creatinine clearance (CrCl) < 60 ml/min/1.73 m2), and with exposure to colchicine, interleukin-1 inhibitors, non-steroidal anti-inflammatory drugs (NSAIDs), and glucocorticoids. All study designs were included. A total of 33 studies with efficacy and/or safety analysis stratified by renal function were reviewed—colchicine (n = 20), anakinra (n = 7), canakinumab (n = 1), NSAIDs (n = 3), and glucocorticoids (n = 2). A total of 58 studies reported these primary outcomes without renal function stratification—colchicine (n = 29), anakinra (n = 10), canakinumab (n = 6), rilonacept (n = 2), NSAIDs (n = 1), and glucocorticoids (n = 10). Most clinical trials excluded study participants with severe CKD (i.e. eGFR or CrCl of < 30 mL/min/1.73 m2). Information on the efficacy and safety outcomes of gout flare prophylaxis and therapy use stratified by renal function is lacking. Clinical trial results cannot be extrapolated for those with advanced CKD. Where possible, current and future gout flare studies should include patients with CKD and with study outcomes reported based on renal function and using standardised gout flare definition.
Presentation of COVID-19 infection with bizarre behavior and encephalopathy: a case report
Authors: Teimouri-Jervekani Zahra , Salmasi Mehrzad 
Published: April 2021

Abstract
Background
Current studies show that patients with severe coronavirus disease 2019 (COVID-19) have neurological symptoms manifesting as acute cerebrovascular diseases, impaired consciousness, and skeletal muscle symptoms. Bizarre behavior is an unusual and unique presenting symptom of COVID-19 infection in our patient.

Case presentation
We report a case of COVID-19 infection in a middle aged Iranian man without underlying disease who presented with bizarre behavior. Results of brain imaging were normal, but COVID-19 pneumonia was detected on chest computed tomography scan. Given the respiratory problem and positive polymerase chain reaction (PCR) test for COVID-19, treatment with hydroxychloroquine was administered, and after 2 days all of the symptoms resolved.

Conclusions
Encephalopathy and encephalitis may be a possible presentation of COVID-19. Clinicians and health care providers should consider the presence of COVID-19 with bizarre behavior during this COVID-19 pandemic.
Massage therapy in infants and children under 5 years of age: protocol for an overview of systematic reviews
Authors: Chen Shu-Cheng , Yu Juan , Yuen Sam Chun-Sum , Lam Jason Chun-Sing , Suen Lorna Kwai-Ping , Yeung Wing-Fai 
Published: April 2021

Abstract
Introduction
Massage is a popularly used complementary and alternative therapy. Previous randomised controlled trials have examined the effects of massage on children, and several systematic reviews have been conducted to synthesise these data. This study aims to assess and summarise the current evidence from published systematic reviews of controlled clinical trials on the practice of paediatric massage, specifically in infants and children aged < 5 years.

Methods
The online databases MEDLINE, Embase, Health Technology Assessment Database, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, Allied and Complementary Medicine, China National Knowledge Infrastructure and Wanfang Data will be searched from the inception onwards for evidence of the treatment effects. We will include systematic reviews of randomised control trials evaluating the effects and safety of massage therapy in infants and children aged < 5 years. The primary outcomes will be any physical or psychological outcome, and adverse effects on children. Secondary outcomes will include any physical or psychological outcome on caregivers. Two reviewers will independently screen the articles for inclusion as per the eligibility criteria. They will extract information from the included studies and assess the methodological quality of the included studies. A table will be used to summarise of information of the included studies, which includes the basic information, method and findings. The methodological quality of the included systematic reviews will be assessed by A Measurement Tool to Assess Systematic Reviews version 2 (AMSTAR 2). Extracted data from the included studies will be collected and presented using narrative approach. The pooled effect estimates for meta-analysed outcomes will be extracted when possible. If there is a discrepancy in results of two or more reviews on the same topic, then the causes of such discrepancy will be further explored.

Discussion
This overview of systematic reviews will summarise the current evidence on massage, specifically for infants and children aged < 5 years. We will comprehensively present the positive effects and adverse effects of this intervention. Findings from this overview will be published in a peer-reviewed journal.

Systematic review registration
CRD42020186003.
Glutaminolysis dynamics during astrocytoma progression correlates with tumor aggressiveness
Authors: Moreira Franco Yollanda E. , Alves Maria Jose , Uno Miyuki , Moretti Isabele Fattori , Trombetta-Lima Marina , de Siqueira Santos Suzana , dos Santos Ancely Ferreira , Arini Gabriel Santos , Baptista Mauricio S. , Lerario Antonio Marcondes , Oba-Shinjo Sueli Mieko , Marie Suely Kazue Nagahashi 
Published: April 2021

Abstract
Background
Glioblastoma is the most frequent and high-grade adult malignant central nervous system tumor. The prognosis is still poor despite the use of combined therapy involving maximal surgical resection, radiotherapy, and chemotherapy. Metabolic reprogramming currently is recognized as one of the hallmarks of cancer. Glutamine metabolism through glutaminolysis has been associated with tumor cell maintenance and survival, and with antioxidative stress through glutathione (GSH) synthesis.

Methods
In the present study, we analyzed the glutaminolysis-related gene expression levels in our cohort of 153 astrocytomas of different malignant grades and 22 non-neoplastic brain samples through qRT-PCR. Additionally, we investigated the protein expression profile of the key regulator of glutaminolysis (GLS), glutamate dehydrogenase (GLUD1), and glutamate pyruvate transaminase (GPT2) in these samples. We also investigated the glutathione synthase (GS) protein profile and the GSH levels in different grades of astrocytomas. The differential gene expressions were validated in silico on the TCGA database.

Results
We found an increase of glutaminase isoform 2 gene (GLSiso2) expression in all grades of astrocytoma compared to non-neoplastic brain tissue, with a gradual expression increment in parallel to malignancy. Genes coding for GLUD1 and GPT2 expression levels varied according to the grade of malignancy, being downregulated in glioblastoma, and upregulated in lower grades of astrocytoma (AGII–AGIII). Significant low GLUD1 and GPT2 protein levels were observed in the mesenchymal subtype of GBM.

Conclusions
In glioblastoma, particularly in the mesenchymal subtype, the downregulation of both genes and proteins (GLUD1 and GPT2) increases the source of glutamate for GSH synthesis and enhances tumor cell fitness due to increased antioxidative capacity. In contrast, in lower-grade astrocytoma, mainly in those harboring the IDH1 mutation, the gene expression profile indicates that tumor cells might be sensitized to oxidative stress due to reduced GSH synthesis. The measurement of GLUD1 and GPT2 metabolic substrates, ammonia, and alanine, by noninvasive MR spectroscopy, may potentially allow the identification of IDH1mut AGII and AGIII progression towards secondary GBM.
Role of LncRNA score and PVT1 in primary hyperparathyroidism-- a preliminary study
Authors: Zhang Dongxue , Wei Bojun , Li Long , Jiang Tao , Yao Xiaoai , Liu Xin , Sun Yuyan 
Published: April 2021

Background Dysregulated lncRNA score and PVT1 expression may be involved in cancer. However, relationships of lncRNAs with hyperparathyroidism and parathyroid cancer (PC) diagnosis remain mysterious. Methods Using quantitative real-time polymerase chain reaction (RT-qPCR), expression profile of PVT1 was evaluated in 57 patients with primary hyperparathyroidism, including 11 with parathyroid cancer (PC) and 46 with parathyroid adenoma (PA). Results Higher levels of lncRNA score and PVT1 expression were associated with increased serum calcium level after water ingestion and PC risk ( P < 0.05). Accordingly, lncRNA score and PVT1 expression were increased with varying degrees of hypercalcemia in PC. A higher level of lncRNA score (but not PVT1) was an independent risk factor of PC, with an AUC up to 0.872 (95% CI: 0.756–0.945, P < 0.001). Moreover, lncRNA score was more valuable (with AUC 0.974, sensitivity of 85.71% and specificity of 100%, respectively) than intact parathyroid hormone (iPTH) in predicting risk of PC among patients with hypercalcemia (especially based on greater AUC, P = 0.010). Conclusion Increased lncRNA score is correlated with an elevated level of serum calcium, which may serve as a potential biomarker for PC diagnosis, especially with hypercalcemia. Graphical Abstract
3D printing 18F radioactive phantoms for PET imaging
Authors: Gillett Daniel , Marsden Daniel , Ballout Safia , Attili Bala , Bird Nick , Heard Sarah , Gurnell Mark , Mendichovszky Iosif A. , Aloj Luigi 
Published: April 2021

Abstract
Purpose
Phantoms are routinely used in molecular imaging to assess scanner performance. However, traditional phantoms with fillable shapes do not replicate human anatomy. 3D-printed phantoms have overcome this by creating phantoms which replicate human anatomy which can be filled with radioactive material. The problem with these is that small objects suffer to a greater extent than larger objects from the effects of inactive walls, and therefore, phantoms without these are desirable. The purpose of this study was to explore the feasibility of creating resin-based 3D-printed phantoms using 18F.

Methods
Radioactive resin was created using an emulsion of printer resin and 18F-FDG. A series of test objects were printed including twenty identical cylinders, ten spheres with increasing diameters (2 to 20 mm), and a double helix. Radioactive concentration uniformity, printing accuracy and the amount of leaching were assessed.

Results
Creating radioactive resin was simple and effective. The radioactive concentration was uniform among identical objects; the CoV of the signal was 0.7% using a gamma counter. The printed cylinders and spheres were found to be within 4% of the model dimensions. A double helix was successfully printed as a test for the printer and appeared as expected on the PET scanner. The amount of radioactivity leached into the water was measurable (0.72%) but not visible above background on the imaging.

Conclusions
Creating an 18F radioactive resin emulsion is a simple and effective way to create accurate and complex phantoms without inactive walls. This technique could be used to print clinically realistic phantoms. However, they are single use and cannot be made hollow without an exit hole. Also, there is a small amount of leaching of the radioactivity to take into consideration.
Stem cell nebulization therapy for COVID-19 infection: radiological and clinical outcomes
Authors: Torres Zambrano Gina M. , Maher Ahmed Yasmine , Ventura Carmenate Yendry , Essam Elsadawy Momena 
Published: April 2021

Abstract
Background
SARS-CoV-2 is a highly contagious virus that spread worldwide with a rapid increase in the number of deaths. In March 2020, the WHO declared SARS-CoV-2 a pandemic. The primary diagnostic test is reverse transcription-polymerase chain reaction, but chest X-ray and computed tomography have become the typical diagnostic tools used to detect abnormal lung changes. Within the framework of the SENTAD COVID Study clinical trial, an observational and analytical study was conducted, where the patients received nebulization therapy with the use of autologous stem cells (group A) compared to the control arm (group B). Both groups received the UAE SARS-CoV-2 standard management. Radiological images of each patient were collected within 24 h of inclusion in the trial and during follow-up. Herein, we describe and evaluate the radiological findings and outcomes.

Results
A total of 139 subjects were included in our analysis, 69 in group A and 70 in group B. The most common finding was ground glass opacifications, followed by patchy consolidations, with 20% normal radiological images scored 3 from admission until discharge (p < 0.0001). Our results suggest a significant improvement in radiological images after treatment secondary to the stem cell effect of reducing inflammation and stimulating the pneumological healing process.

Conclusions
The use of novel therapies, such as stem cells, shows efficacy not only in terms of the control of clinical and paraclinical signs but also in the radiological changes described in the disease.

Trial registration
Study evaluating the safety and efficacy of autologous non-hematopoietic peripheral blood stem cells in COVID-19. Trial registration number: NCT04473170. Date of registration: 16 July 20202. Retrospectively registered.
Feasibility of Cell-Free DNA Collection and Clonal Immunoglobulin Sequencing in South African Patients With HIV-Associated Lymphoma
Authors: Vogt Samantha L. , Patel Moosa , Lakha Atul , Philip Vinitha , Omar Tanvier , Ashmore Philippa , Pather Sugeshnee , Haley Lisa M. , Zheng Gang , Stone Jennifer , Mayne Elizabeth , Stevens Wendy , Wagner-Johnston Nina , Gocke Christopher D. , Martinson Neil A. , Ambinder Richard F. , Xian Rena R. 
Published: April 2021

PURPOSEDiagnosis of AIDS lymphoma in low-resource settings, like South Africa, is often delayed, leaving patients with limited treatment options. In tuberculosis (TB) endemic regions, overlapping signs and symptoms often lead to diagnostic delays. Assessment of plasma cell-free DNA (cfDNA) by next-generation sequencing (NGS) may expedite the diagnosis of lymphoma but requires high-quality cfDNA.METHODSPeople living with HIV with newly diagnosed aggressive B-cell lymphoma and those with newly diagnosed TB seeking care at Chris Hani Baragwanath Academic Hospital and its surrounding clinics, in Soweto, South Africa, were enrolled in this study. Each participant provided a whole blood specimen collected in cell-stabilizing tubes. Quantity and quality of plasma cfDNA were assessed. NGS of the immunoglobulin heavy chain was performed.RESULTSNine HIV+ patients with untreated lymphoma and eight HIV+ patients with TB, but without lymphoma, were enrolled. All cfDNA quantity and quality metrics were similar between the two groups, except that cfDNA accounted for a larger fraction of recovered plasma DNA in patients with lymphoma. The concentration of cfDNA in plasma also trended higher in patients with lymphoma. NGS of immunoglobulin heavy chain showed robust amplification of DNA, with large amplicons (> 250 bp) being more readily detected in patients with lymphoma. Clonal sequences were detected in five of nine patients with lymphoma, and none of the patients with TB.CONCLUSIONThis proof-of-principle study demonstrates that whole blood collected for cfDNA in a low-resource setting is suitable for sophisticated sequencing analyses, including clonal immunoglobulin NGS. The detection of clonal sequences in more than half of patients with lymphoma shows promise as a diagnostic marker that may be explored in future studies.
Introduction
Authors: Banks Elizabeth , d'Avignon Robyn , Siddiqi Asif 
Published: April 2021

AbstractThis special themed section examines the multilayered engagements between Africa and the Soviet Union as a central, if overlooked, global encounter of the mid-twentieth century. We call this worldview and the entanglements it generated the “African-Soviet Modern,” an asymmetrical combination of aspiration, materiality, and practice that was rooted in diverse African states and in the Soviet Union. As an analytical category, the African-Soviet Modern speaks to the gap between the grand rhetorical and ideological scope of the Cold War moment and the relatively discrete channels in which it materialized, which gave this mode of thinking a particular vitality and instability. African-Soviet entanglements unfolded in an expansive and uneven geography that incorporated diverse regions of Africa, the USSR, and beyond. Avoiding the temporal and spatial silos of either Soviet or African history, the four essays in this section focus on the spaces where African and Soviet students, politicians, and scientists interacted with one another, creating “connected chronologies” and complementary archives of evidence. Weaving together documentary and oral sources, these articles recover a global entanglement that was energized by unbounded political, economic, and technological aspiration, but that produced an uneven material footprint in newly independent African states.
Shaping the World
Authors: Siddiqi Asif 
Published: April 2021

Abstract
This article explores the biography of a network of Soviet telescopic cameras stationed across the African Sahel during the Cold War. Through joint Soviet-African cooperative programs, scientists used these advanced cameras in Egypt, Somalia, Mali, the Sudan, and Chad to photograph satellites flying overhead to gather data to produce a new model of the Earth, one that Soviet scientists hoped would be an alternative to Western models. I argue that these technical artifacts in Africa, connected into a single global network, represented examples of “infrastructural irruptions” of Cold War technopolitics into African geography, wherein the superpowers placed networked technologies inside postcolonial spaces for the collection of data. Although these technologies were nominally Soviet in origin, the story could also be read as one of Africans who invested their geography with agency in the production of scientific knowledge. Like the socialist moment in Africa and indeed the Soviet Union itself, this camera network no longer exists, its data compromised and its material imprint disappeared. But this “failure” should not blind us to the immanent power of possibility embedded in this incomplete project. I argue that this combination of unbounded aspiration and incomplete materiality was a powerful manifestation of the African-Soviet Modern.
The Affective Feminism of Ghazaleh Hedayat
Authors: Torshizi Foad 
Published: April 2021

AbstractThis article examines the works of the Iranian contemporary artist, Ghazaleh Hedayat. It argues that her turn from figural representation to nonfigural abstraction and consequently to what Laura Marks has called “haptic visuality” demonstrates a careful and systematic aesthetic strategy that attempts to confront and at times even exit representation. It shows that Hedayat's works since the early 2010s offer an affective approach to feminism in contemporary Iranian art that doesn't hinge on representational modes of expression, which are often susceptible to assimilation into identitarian narratives and inadvertently complicit in various forms of marginalization (gender, ethnic, etc.). Hedayat's affective feminism not only complicates clichéd interpretations of her work as a non-Western woman, but it also materializes a new form of knowledge more in tune with feminism. Focusing on the female body as a site of pain, friction, tension, love, maternality, and, more significantly, as a site where self and its other—both in terms of gender and ethnicity—encounter each other, Hedayat undermines visibility by way of pushing it across the borders of sight into the realms of visuality, haptic experience, and proprioception.
Rapid systematic review of systematic reviews: what befriending, social support and low intensity psychosocial interventions, delivered remotely, may reduce social isolation and loneliness among older adults and how?
Authors: Boulton Elisabeth , Kneale Dylan , Stansfield Claire , Heron Paul , Sutcliffe Katy , Hayanga Brenda , Hall Alex , Bower Peter , Casey Dympna , Craig Dawn , Gilbody Simon , Hanratty Barbara , McMillan Dean , Thomas James , Todd Chris 
Published: April 2021

Background: During the COVID-19 pandemic ‘social distancing’ has highlighted the need to minimise loneliness and isolation among older adults (aged 50+). We wanted to know what remotely delivered befriending, social support and low intensity psychosocial interventions may help to alleviate social isolation and loneliness and how they work.Methods: We followed a systematic ‘review of reviews’ approach. Searches of 11 databases from the fields of health, social care, psychology and social science were undertaken during April 2020. Reviews meeting our PICOS criteria were included if they focussed on the evaluation of remote interventions to reduce levels of social isolation or loneliness in adults aged 50+ and were critically appraised using AMSTAR2. Narrative synthesis was used at a review and study level to develop a typology of intervention types and their effectiveness. Intervention Component Analysis (ICA) and Qualitative Comparative Analysis (QCA) were used at a study level to explore the characteristics of successful interventions.Results: We synthesised evidence from five systematic reviews and 18 primary studies. Remote befriending, social support and low intensity psychosocial interventions took the form of: (i) supported video-communication; (ii) online discussion groups and forums; (iii) telephone befriending; (iv) social networking sites; and (v) multi-tool interventions. The majority of studies utilised the first two approaches, and were generally regarded positively by older adults, although with mixed evidence around effectiveness. Focussing on processes and mechanisms, using ICA and QCA, we found that the interventions that were most successful in improving social support: (i) enabled participants to speak freely and to form close relationships; (ii) ensured participants have shared experiences/characteristics; (iii) included some form of pastoral guidance.Conclusions: The findings highlight a set of intervention processes that should be incorporated into interventions, although they do not lead us to recommend specific modes of support, due to the heterogeneity of interventions.