bluuebunny/crossref_metadata_2025_split huggingface dataset:
Periodic Event Scheduling for Automated Production Systems
Authors: Helmberg Christoph , Hofmann Tobias , Wenzel David 
Published: December 2021

Consider optimizing a periodic schedule for an automated production plant as a last step of a more comprehensive design process. In our scenario, each robot’s cyclic sequence of operations and trajectories between potential waiting points have already been fully specified. Further given are those precedences that fix sequence requirements on operations between different robots. It remains to determine the starting time for each operation or movement of each robot within a common cyclic time period so as to avoid collisions of robots that operate in the same space simultaneously. So the task is to find a conflict-resolving schedule that minimizes this common periodic cycle time while observing all precedence relations and collision avoidance constraints. The proposed cycle time minimization problem for robot coordination has, to the best of our knowledge, not been studied before. We develop an approach for solving it by employing binary search for determining the smallest feasible period time of an iso-periodic event scheduling problem (IPESP). This is a variant of the periodic event scheduling problem in which the objects that have to be scheduled need to obey exactly the same period time. The possibility to wait arbitrarily long at waiting points turns out to be essential to justify the use of binary search for identifying the minimum cycle time, thereby avoiding bilinear mixed integer formulations. Special properties of the given scenario admit bounds on the periodic tension variables of an integer programming formulation. Although the IPESP subproblems remain NP-complete in general, these bounds allow solving real-world instances sufficiently fast for the approach to be applicable in practice. Numerical experiments on real-world and randomly generated data are supplied to illustrate the potential and limitations of this approach. Summary of Contribution: When designing automated production plants, a crucial step is to identify the smallest possible per unit period time for the production processes. Based on periodic event scheduling ideas, we develop and analyze mathematical methods for this purpose. We show that the algorithmic implementation of our approach provides an answer to current real-world designs in reasonable time.
Numerical Analysis to Predict Temperature Distribution of Passion Fruit Seeds During Drying
Authors: Azis Atri Dewi 
Published: December 2021

HighlightsA temperature distribution occurred due to temperature differences between the surface and inside passion fruit seeds.The temperature distribution occurred simultaneously in all directions.The temperature distribution decreased at greater depths inside the seeds.The same temperature distribution pattern occurred in the vertical and horizontal directions.Abstract. Optimization of the drying process can be determined based on temperature distribution patterns using numerical analysis with the finite element method (FEM). This study compiled a numerical analysis using FEM to predict the temperature distribution in passion fruit seeds during drying. The study was conducted using a circulating-air tray dryer. Temperature distribution data on passion fruit seeds were measured using a data logger. The results showed that numerical analysis using FEM quickly and accurately simulated the temperature distribution in passion fruit seeds during drying. The model was validated by comparing the temperature distribution data measured in the drying chamber with the simulation results, with a relative error of 0.45% to 1.27%. Numerical analysis using FEM provides an useful reference for controlling temperature distribution during drying because this method is easy to implement and results in low errors. Keywords: Drying, Finite element methods, Numerical analysis, Passion fruit seeds, Temperature distribution.
Anforderungen sicherheitskritischer Dienste an Augmented Reality-Lösungen – Wassertiefenmessung in einem Seehafen
Authors: Bräker Julia , Osterbrink Anna , Wiesche Manuel , Semmann Martin 
Published: December 2021

ZusammenfassungAugmented Reality ist eine zunehmend weiter verbreitete Technologie. Die Potenziale in Bereichen außergewöhnlich hoher kognitiver Anforderungen in sicherheitskritischen Kontexten sind bisher allerdings wenig untersucht. Insbesondere Dienstleistungen, die umfassendes Fachwissen voraussetzen, sicherheitskritisch sind und parallel auszuführende Aufgaben erfordern, können durch den Einsatz von Augmented Reality in ihrer Ausführung unterstützt werden. In solchen Dienstleistungen ermöglicht Augmented Reality eine nahtlose Integration wesentlicher Informationen in das Sichtfeld der Nutzenden. Beim Einsatz von Head-Mounted Displays kann zudem eine freihändige Interaktion erfolgen. Diese Arbeit untersucht die nutzerzentrierten Anforderungen an Augmented Reality-Lösungen in einem sicherheitskritischen Bereich im Betrieb eines großen europäischen Seehafens. Konkret geht es um Wassertiefenmessung des gesamten Hafengebiets zur Instandhaltung der Hafeninfrastruktur. Basierend auf elf Think-Aloud-Sitzungen während der Messfahrten, zwei Experteninterviews und zwei Expertenworkshops, wurden fünf Anforderungen an Augmented Reality bei der Wassertiefenmessung abgeleitet, die eine Lösung zur Unterstützung der Dienstleistung erfüllen sollte. Unseres Wissens nach präsentieren wir damit die erste Studie zur Anwendbarkeit und Umsetzbarkeit von Augmented Reality in der maritimen Industrie und identifizieren Anforderungen, die sich auf die weitere Forschung zum Einsatz von Augmented Reality in sicherheitskritischen Umgebungen übertragen lassen.
Association between grip strength and anthropometric characteristics in the community-dwelling elderly population in Taiwan
Authors: Lin Ming-Hsun , Chang Chun-Yung , Lu Chieh-Hua , Wu Der-Min , Kuo Feng-Chih , Kuo Che-Chun , Chu Nain-Feng 
Published: December 2021

Background
Sarcopenia and muscle weakness in elderly are contributed burden of public health and impact on quality of life. Weak grip strength was key role in diagnosis of sarcopenia and reported increased mortality, function declined in elderly. This study evaluated the association between GS and each common anthropometric characteristic in community-dwelling elderly.

Design and method
From 2017 to 2019, we conducted a community-based health survey among the elderly in Chiayi county, Taiwan. Participants were 65 years old or older, and total of 3,739 elderly subjects (1,600 males and 2,139 females) with a mean age of 76 years (range 65–85 years old) were recruited. General demographic data and lifestyle patterns were measured using a standard questionnaire. Anthropometric characteristics such as body height, body weight, body mass index (BMI), body waist and hip circumference, and body fat were measured by standard methods. GS was measured using a digital dynamometers (TKK5101) method.

Results
The mean GS was 32.8 ± 7.1 kg for males and 21.6 ± 4.8 kg for females (p < 0.001). For both sexes, elderly subjects with the same body weight but smaller body waist circumference had greater GS. The subjects with the same body waist size but heavier weight had greater GS. Furthermore, after adjusting for age, lifestyles, disease status, and potential anthropometric variable, multivariate regression analyses indicated that BMI was positively associated with GS (for males, beta = 0.310 and for females beta = 0.143, both p < 0.001) and body waist was negatively associated with GS (for males, beta = −0.108, p < 0.001; for females, beta = −0.030, p = 0.061).

Conclusions
This study suggested that old adults with higher waist circumstance had weaker GS. Waist circumstance was negatively associated with GS, body weight was positively associated with GS in contrast. It may implies that central obesity was more important than overweight for GS in elderly.
The implications of parent mental health and wellbeing for parent-child attachment: A systematic review
Authors: Risi Alixandra , Pickard Judy A. , Bird Amy L. 
Published: December 2021

BackgroundParent mental health and wellbeing may have implications for understanding attachment transmission. In this systematic review, we synthesise the published literature to determine the nature of the relationship between parent mental health and wellbeing and the intergenerational transmission of attachment and to provide recommendations for future research, clinical practice and intervention.MethodUsing the preferred reporting items for systematic reviews and meta-analyses (PRISMA) approach, five electronic databases were searched for peer-reviewed empirical studies, published in English. Articles were considered for inclusion if data was collected on adult attachment, child attachment, and a domain of parent mental health/wellbeing. No date parameters were applied to the search strategy. The review was registered with PROPSERO (registration number: CRD42020157247).ResultsEleven studies examining the impact on parent mental health and wellbeing on the intergenerational transmission of attachment were identified for inclusion in this review. Our review found preliminary evidence that parent mental health and wellbeing play a role in the intergenerational transmission of attachment. Other key findings from the review were: evidence quality is mixed due to variable measurement of attachment and mental health; studies have mostly included correlational analysis or do not utilise contemporary methodological approaches to testing mediating or moderating relationships; and literature is largely focused on psychopathology and negative factors of mental health.ConclusionsThe limited scope of parent mental health and wellbeing constructs examined in the literature, the sparse use of robust statistical analyses, and the lack of literature in general makes it difficult to draw conclusions on how and why parent mental health impacts attachment transmission. Addressing these limitations will further progress attachment-related literature and may have particular implications for attachment-informed interventions with clinical populations.
Protocol: A mixed methods evaluation of an IPS program to increase employment and well-being for people with long-term experience of complex barriers in Vancouver’s downtown and DTES
Authors: Kwan Amanda , Morris Jonny , Barbic Skye P. 
Published: December 2021

Background
Employment improves mental health and well-being by providing financial security, daily structure, a sense of identity and purpose, and social engagement. However, securing and sustaining employment is exceptionally challenging for vulnerable populations who experience persistent and multiple barriers, such as mental illness, homelessness, food and housing insecurity, and marginalization. Evidence-based supported employment programs, most notably individual placement and support (IPS) are becoming a more common approach for addressing the needs of these high-risk individuals. The aim of this paper is to outline the protocol for evaluating an IPS program in Vancouver’s downtown and Downtown Eastside (DTES).

Methods and design
This prospective quasi-experimental study of persons with persistent and multiple barriers to employment will use a mixed-methods approach for evaluating a novel IPS program. The evaluation will consist of survey packages and interviews that will capture outcomes related to employment and well-being, as well as the experiential process of receiving individualized and integrated supports through the IPS program. A mixed-methods approach is appropriate for this study as quantitative data will provide an objective assessment of program impacts on employment and well-being outcomes over time, while qualitative data will provide an in-depth understanding of continued barriers and experiences.

Discussion
The results from this evaluation will contribute evidence within a local British Columbian (BC) context that may increase access to meaningful employment for those with long-term experience of complex barriers to employment. Further, the findings will support continued improvements, and guide decision-making around practices and policy for future implementation of IPS and employment supports across BC.
Eficacia de la combinación de Abamectina-Derquantel y de la Moxidectina en cabras lecheras naturalmente parasitadas con nematodos gastrointestinales en el Valle de Lerma, Argentina
Authors: OLMOS Leandro Hipólito , MARTÍNEZ Gabriela M. , ALFARO Rodolfo J. , DIAZ Juan P. , SUAREZ Víctor H. 
Published: December 2021

El impacto productivo de los nematodos gastrointestinales (NGI) sobre los de pequeños rumiantes es conocido a nivel mundial. Las infestaciones por NGI constituyen una limitante de alto impacto en la producción de rumiantes y las perdidas comprendidas por este problema sanitario varían desde reducciones subclínicas en la ganancia de peso hasta la muerte de animales con altas cargas parasitarias. El objetivo de este trabajo es presentar los resultados de un test de eficacia a campo utilizando una combinación comercial de Abamectina + Derquantel y del Moxidectin en cabras lecheras naturalmente infestadas con NGI en el Valle de Lerma, provincia de Salta. El ensayo se llevó a cabo en la Unidad Tambo Caprino de la Estación Experimental Agropecuaria Salta del INTA. Para la evaluación de eficacia de la droga en estudio, se realizó el test de reducción de conteos de huevos. En los coprocultivos pre-tratamientos se pudo observar una gran prevalencia de Trichostrongylus spp. (71%). seguido de Teladorsagia spp. (21%) y Haemonchus spp. (8%). En cuanto a los resultados del TRCH, en el GDQ se observaron valores del 100% de PRCH, mientras que en el GMX se observó un PRCH de 95,5 %, donde la eficacia para Haemonchus spp. y Teladorsagia spp. fue del 100% y para Trichostrongylus spp. del 81,1%.Los resultados observados en este trabajo permiten concluir que en las condiciones de campo en donde fue llevado a cabo el TRCH, la combinación Derquantel-Abamectina posee una alta eficacia contra los géneros presentes
Serum amyloid A as a marker of ankylosing spondylitis activity
Authors: Sakharova K. V. , Cherkasova M. V. , Erdes Sh. F. 
Published: December 2021

Serum amyloid A protein A (SAA) is a normal serum protein (serving as a precursor of fibrillar tissue protein AA), synthesized in the liver and a rapidly responding marker of the acute phase of inflammation. A constant high concentration of SAA is one of the factors in the development of AA-amyloidosis. As a rule, secondary amyloidosis develops in patients with long-term and poorly controlled inflammatory diseases, including rheumatic diseases, one of which is ankylosing spondylitis (AS).Objective: to assess the level of SAA in AS patients and its relationship with indicators of disease activity.Patients and methods. The study included 124 patients with AS who met the modified New York 1984 criteria. The disease activity and functional status of patients were assessed according to the recommendations of Russian experts. SAA and CRP, ESR in blood serum were measured in all patients.Results and discussion. The median SAA concentration was 12.5 mg/L [4; 71.6]. Of 124 patients, 31% had SAA levels <5 mg/L and 69% had >5 mg/L. A strong correlation was found between the levels of SAA and CRP (r=0.80, p<0.000001), no significant relationship was found between SAA and ESR (r=0.31, p=0.92). The correlation between the AS activity according to the BASDAI index and SAA was weak (r=0.3, p<0.002), the correlation with ASDAS-CRP was moderate (r=0.54, p<0.00001).Conclusion. A statistically significant relationship was found between SAA and CRP levels, as well as the AS activity indices. Research has shown that SAA can be used as one of the markers of inflammation in AS.
Long-term use of nonsteroidal anti-inflammatory drugs for pain control in patients with osteoarthritis: results of the 12-month observational study AELITA (Analgesia: Effective Treatment Using The Therapeutic Algorithm)
Authors: Karateev A. E. , Polishchuk E. Yu. , Filatova E. S. , Potapova A. S. , Nesterenko V. A. , Amirdzhanova V. N. 
Published: December 2021

Non-steroidal anti-inflammatory drugs (NSAIDs) are the primary means of managing chronic osteoarthritis (OA) pain. The choice of NSAIDs is based on an analysis of the risk of adverse reactions (ARs). Objective: to evaluate the efficacy and safety of long-term use of NSAIDs for pain control in patients with OA in real clinical practice.Patients and methods. To assess the results of long-term use of NSAIDs in OA, a 12-month observational non-interventional study was conducted. It included 611 patients with knee, hip and generalized OA, and nonspecific back pain associated with OA of the facet joints. All patients were prescribed aceclofenac (Aertal®) 200 mg/day. The patients' condition was assessed 2 weeks, 3, 6, 9 and 12 months after the start of therapy. The following parameters were determined: the intensity of pain during movement and the general health assessment (GA) according to the visual analogue scale (VAS, 10 cm); pain intensity according to the Likert verbal rating scale (VRS) (0–4); the number of patients with a pain reduction of ≥50% from baseline; patients' assessment of the result of therapy according to Likert VRS (1–5). The development of ARs was recorded at each visit.Results and discussion. By month 12, 46.8% of patients had dropped out of observation. In patients who continued the study, the average severity of pain according to the VAS at baseline, after 2 weeks, 3, 6, 9 and 12 months was: 6.5±1.2; 4.8±1.4; 3.2±1.4; 2.6±1.4; 2.2±1.1; 1.4±1.1 cm, respectively (significant differences compared to the baseline for all points – p<0.05). The same differences were obtained in GA assessment.Within the indicated time frame, the number of patients with moderate / severe pain (on the Likert scale) decreased from 77.8 to 24.9; 2.9; 2.3; 0.9 and 0%, respectively. The number of patients with a pain reduction of ≥50% from baseline was 12.0; 65.1; 81.0; 88.5 and 84.0%, respectively. A good or excellent assessment of treatment results after 2 weeks was given by 63.3% of patients, and after 12 months – by 95.6%. ARs were observed in about 30% of patients, mainly mild or moderate dyspepsia (in 11.1–23.3%) and arterial hypertension (in 7.1–10.9%). No serious ARs were registered.Conclusion. Aceclofenac is an effective and relatively safe drug for the long-term management of chronic pain in OA.
Naughty Girl, or Not a Girl? Behavior and Becoming in Les Malheurs de Sophie
Authors: Mangerson Polly T. 
Published: December 2021

Abstract
This study presents a critical analysis of the classic nineteenth-century French children’s novel Les Malheurs de Sophie, written by the Comtesse de Ségur. The story follows the misadventures of a mischievous little girl in order to highlight the consequences of her naughty behavior and provide a counter-example for Ségur’s young female readers. In this article, Mangerson draws upon scholarship in both queer theory and early childhood psychology to demonstrate that Sophie’s inappropriate behavior can be interpreted by the modern reader as evidence of gender fluidity. Mangerson examines Sophie’s misuse of gender-specific toys, her curiosity to explore forbidden spaces, and her failure to conform to her peers. This study argues that this “naughty girl” is perhaps “not a girl,” and that her behavior is indicative of the process of gender identity formation, which is strongly influenced by socio-historical constructs of femininity.
Brain imaging genomics: influences of genomic variability on the structure and function of the human brain
Authors: Mühleisen Thomas W. , Forstner Andreas J. , Hoffmann Per , Cichon Sven 
Published: December 2021

Abstract
Brain imaging genomics is an emerging discipline in which genomic and brain imaging data are integrated in order to elucidate the molecular mechanisms that underly brain phenotypes and diseases, including neuropsychiatric disorders. As with all genetic analyses of complex traits and diseases, brain imaging genomics has evolved from small, individual candidate gene investigations towards large, collaborative genome-wide association studies. Recent investigations, mostly population-based, have studied well-powered cohorts comprising tens of thousands of individuals and identified multiple robust associations of single-nucleotide polymorphisms and copy number variants with structural and functional brain phenotypes. Such systematic genomic screens of millions of genetic variants have generated initial insights into the genetic architecture of brain phenotypes and demonstrated that their etiology is polygenic in nature, involving multiple common variants with small effect sizes and rare variants with larger effect sizes. Ongoing international collaborative initiatives are now working to obtain a more complete picture of the underlying biology. As in other complex phenotypes, novel approaches – such as gene–gene interaction, gene–environment interaction, and epigenetic analyses – are being implemented in order to investigate their contribution to the observed phenotypic variability. An important consideration for future research will be the translation of brain imaging genomics findings into clinical practice.
Spinal muscular atrophy (5qSMA): best practice of diagnostics, newborn screening and therapy
Authors: Eggermann Katja , Gläser Dieter , Abicht Angela , Wirth Brunhilde 
Published: December 2021

AbstractProximal spinal muscular atrophy (SMA) is an autosomal-recessive inherited neuromuscular disorder caused by the degeneration of alpha motor neurons in the anterior horn of the spinal cord. Patients show hypotonia, muscular atrophy and weakness of voluntary proximal muscles. SMA is one of the most common genetic diseases, with a frequency of about 1 in 7,000 newborns in Germany. The vast majority of patients carry a homozygous deletion of exons 7 and 8 of the survival motor neuron (SMN) 1 gene on chromosome 5q13.2; only about 3–4 % of patients are compound heterozygous for this common mutation and an additional subtle mutation inSMN1. The severity of the disease is mainly influenced by the copy number of the highly homologousSMN2.Since the discovery of the underlying genetic defect 25 years ago, both the diagnostics of SMA and its treatment have undergone constant and in recent times rapid improvements. SMA has become one of the first neuromuscular disorders with effective therapies based on gene targeted strategies such as splice correction ofSMN2via antisense oligonucleotides or small molecules or gene replacement therapy with a self-complementary adeno-associated virus 9 expressing theSMN1-cDNA. With the availability of treatment options, which are most effective when therapy starts at a pre-symptomatic stage, a newborn screening is indispensable and about to be introduced in Germany. New challenges for diagnostic labs as well as for genetic counsellors are inevitable.This article aims at summarising the current state of SMA diagnostics, treatment and perspectives for this disorder and offering best practice testing guidelines to diagnostic labs.