bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engineered Bio‐inspired Multifunctional Peptide‐ and Protein‐based Therapeutic Biomolecules for Better Wound Care
Authors: Gayen Paramita , Jan Somnath , Chowdhury Nilkanta , Ghosh Snehasish , Hembram Monjuri , Bagchi Angshuman , Sinha Roy Rituparna 
Published: October 2021

AbstractDeveloping non‐immunogenic therapeutic biomolecules for facilitating blood clotting followed by wound healing via therapeutic angiogenesis, still remains a formidable challenge. Excessive blood loss of accident victims and battalions cause a huge number of deaths worldwide. Patients with inherited bleeding disorders face acute complications during injury and post‐surgery. Biologically‐inspired peptide‐based hemostat can act as a potential therapeutic for handling coagulopathy. Additionally, non‐healing wounds for patients having ischemic diseases can cause severe clinical complications. Advancement in stabilized growth‐factor‐based proangiogenic therapy may offer effective possibilities for the treatment of ischemic pathology. This review will discuss nature‐inspired biocompatible stabilized peptide‐ and protein‐based molecular medicines to serve unmet medical challenges for handling traumatic coagulopathy and impaired wound healing.
National trends and survival outcomes of penile squamous cell carcinoma based on human papillomavirus status
Authors: Chipollini Juan , Pollock Grant , Hsu Chiu‐Hsieh , Batai Ken , Recio‐Boiles Alejandro , Lee Benjamin R. 
Published: October 2021

AbstractBackgroundThere are no series evaluating penile squamous cell carcinoma (pSCC) based on human papillomavirus (HPV) infection. Herein, we present national registry data on clinical and survival outcomes for pSCC based on HPV status.MethodsWe performed a retrospective review of 1224 pSCC patients with known HPV staining from the National Cancer Database. Patients with cM1 disease, those who did not receive treatment, or had missing follow‐up data were excluded. Logistic regression identified factors associated with locally aggressive disease. Univariable, multivariable, and inverse probability of treatment weighting (IPTW)‐Cox proportional hazard modeling were used to assess hazard ratios (HR) associated with overall survival (OS).ResultsAfter exclusion criteria, we identified 825 cases of which 321 (38.9%) were HPV positive. The HPV‐positivity rate did not significantly change by year. HPV‐positive patients were younger, had lower Charlson‐Deyo performance score, and resided in areas with both lower median household income and lower school education completion. HPV‐positive tumors presented with lower American Joint Committee on Cancer clinical T‐stage (cT), poorer differentiation, lower rates of lymphovascular invasion (LVI), but more node‐positive disease (cN+). For those who underwent lymph node surgery, there were no differences in final pathologic stage, upstaging, or presence of extranodal extension. Only tumor differentiation, LVI, and performance score were independent predictors for locally aggressive disease. HPV status was not a predictor of OS (IPTW‐HR:0.89, p = 0.13).ConclusionsIn the largest series evaluating pSCC based on HPV status, HPV‐positive tumors were associated with lower cT stages, less LVI, but more cN + disease. More studies on prognostic factors are needed, and time may still be immature to use HPV information for risk stratification.
Discovery of Isatin‐Based Carbohydrazones as Potential Dual Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase
Authors: Jaiswal Shivani , Ayyannan Senthil Raja 
Published: October 2021

AbstractUsing ligand‐based design strategy, a set of isatin‐3‐carbohydrazones was designed, synthesized and evaluated for dual fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibition properties. Compound 5‐chloro‐N′‐(5‐chloro‐2‐oxoindolin‐3‐ylidene)‐2‐hydroxybenzohydrazide (13 b) emerged as a potent MAGL inhibitor with nanomolar activity (IC50=3.33 nM), while compound 5‐chloro‐N′‐(1‐(4‐fluorobenzyl)‐2‐oxoindolin‐3‐ylidene)‐2‐hydroxybenzohydrazide (13 j) was the most potent selective FAAH inhibitor (IC50=37 nM). Compound 5‐chloro‐N′‐(6‐chloro‐2‐oxoindolin‐3‐ylidene)‐2‐hydroxybenzohydrazide (13 c) showed dual FAAH‐MAGL inhibitory activity with an IC50of 31 and 29 nM respectively. Enzyme kinetics studies revealed that the isatin‐based carbohydrazones are reversible inhibitors for both FAAH and MAGL. Further, blood‐brain permeability assay confirmed that the lead compounds (13 b,13 c,13 g,13 mand13 q) are suitable as CNS candidates. Molecular dynamics simulation studies revealed the putative binding modes and key interactions of lead inhibitors within the enzyme active sites. The lead dual FAAH‐MAGL inhibitor13 cshowed significant antioxidant activity and neuroprotection in the cell‐based cytotoxicity assay. In summary, the study yielded three potent FAAH/MAGL inhibitor compounds (13 b,13 cand13 j) with acceptable pharmacokinetic profile and thus can be considered as promising candidates for treating neurological and mood disorders.
Development of an Off‐Grid Solar‐Powered Autonomous Chemical Mini‐Plant for Producing Fine Chemicals
Authors: Masson Tom M. , Zondag Stefan D. A. , Kuijpers Koen P. L. , Cambié Dario , Debije Michael G. , Noël Timothy 
Published: October 2021

AbstractPhotochemistry using inexhaustible solar energy is an eco‐friendly way to produce fine chemicals outside the typical laboratory or chemical plant environment. However, variations in solar irradiation conditions and the need for an external energy source to power electronic components limits the accessibility of this approach. In this work, a chemical solar‐driven “mini‐plant” centred around a scaled‐up luminescent solar concentrator photomicroreactor (LSC‐PM) was built. To account for the variations in solar irradiance at ground level and passing clouds, a responsive control system was designed that rapidly adapts the flow rate of the reagents to the light received by the reaction channels. Supplying the plant with solar panels, integrated into the module by placing it behind the LSC to utilize the transmitted fraction of the solar irradiation, allowed this setup to be self‐sufficient and fully operational off‐grid. Such a system can shine in isolated environments and in a distributed manufacturing world, allowing to decentralize the production of fine chemicals.
Mechanisms of oligodendrocyte progenitor developmental migration
Authors: Xia Wenlong , Fancy Stephen P. J. 
Published: October 2021

AbstractOligodendrocytes, the myelinating cells of the central nervous system (CNS), develop from oligodendrocyte progenitor cells (OPCs) that must first migrate extensively throughout the developing brain and spinal cord. Specified at particular times from discrete regions in the developing CNS, OPCs are one of the most migratory of cell types and disperse rapidly. A variety of factors act on OPCs to trigger intracellular changes that regulate their migration. We will discuss factors that act as long‐range guidance cues, those that act to regulate cellular motility, and those that are critical in determining the final positioning of OPCs. In addition, recent evidence has identified the vasculature as the physical substrate used by OPCs for their migration. Several new findings relating to this oligodendroglial–vascular signaling axis reveal new insight on the relationship between OPCs and blood vessels in the developing and adult brain.
Using seminatural and simulated habitats for seed germination ecology of banana wild relatives
Authors: Kallow Simon , Quaghebeur Katrijn , Panis Bart , Janssens Steven B. , Dickie John , Gueco Lavernee , Swennen Rony , Vandelook Filip 
Published: October 2021

Abstract

Ecologically meaningful seed germination experiments are constrained by access to seeds and relevant environments for testing at the same time. This is particularly the case when research is carried out far from the native area of the studied species.

Here, we demonstrate an alternative—the use of glasshouses in botanic gardens as simulated‐natural habitats to extend the ecological interpretation of germination studies. Our focal taxa were banana crop wild relatives (Musa acuminata subsp. burmannica, Musa acuminata subsp. siamea, and Musa balbisiana), native to tropical and subtropical South‐East Asia. Tests were carried out in Belgium, where we performed germination tests in relation to foliage‐shading/exposure to solar radiation and seed burial depth, as well as seed survival and dormancy release in the soil. We calibrated the interpretation of these studies by also conducting an experiment in a seminatural habitat in a species native range (M. balbisiana—Los Baños, the Philippines), where we tested germination responses to exposure to sun/shade. Using temperature data loggers, we determined temperature dynamics suitable for germination in both these settings.

In these seminatural and simulated‐natural habitats, seeds germinated in response to exposure to direct solar radiation. Seed burial depth had a significant but marginal effect by comparison, even when seeds were buried to 7 cm in the soil. Temperatures at sun‐exposed compared with shaded environments differed by only a few degrees Celsius. Maximum temperature of the period prior to germination was the most significant contributor to germination responses and germination increased linearly above a threshold of 23℃ to the maximum temperature in the soil (in simulated‐natural habitats) of 35℃.

Glasshouses can provide useful environments to aid interpretation of seed germination responses to environmental niches.
Chief executive officer power and initial public offering underpricing: Examining the influence of demand‐side cultural power distance
Authors: Krause Ryan , Chen Juanyi , Bruton Garry D. , Filatotchev Igor 
Published: October 2021

AbstractResearch SummaryInitial public offering (IPO) underpricing reflects the inability of early investors to capture the full value of an entrepreneurial firm. IPO firms can potentially limit underpricing by signaling wealth protection through lower chief executive officer (CEO) power. Such signaling is particularly challenging for many IPO firms, though, because for those doing business in high‐power‐distance cultures, CEO power can also signal wealth creation, making CEO power a mixed signal for IPO investors. Drawing on signaling theory, we argue that CEO power is positively associated with IPO underpricing, but this relationship weakens for IPO firms doing business in countries with high cultural power distance because the information signaled becomes less clear. The signaling impact of both CEO power and demand‐side cultural power distance weakens, however, when underwriter reputation offers a substitute signal.Managerial SummaryThis research offers new knowledge for IPO corporate governance practitioners, such as entrepreneurs, venture capitalists, underwriters, and regulators. Specifically, our research demonstrates that the power dynamic in the upper echelons has implications for demand‐side legitimacy or making U.S.‐listed firms more legitimate with international customers. As a result, stockholders and securities analysts who balk at the consolidation of CEO power should consider the potential benefits that such consolidation of power might grant the firm when competing in different cultural environments associated with foreign markets.
Highly Emissive and Stable Five‐Coordinated Manganese(II) Complex for X‐Ray Imaging
Authors: Meng Haixing , Zhu Wenjuan , Li Feiyang , Huang Xiaomeng , Qin Yanyan , Liu Shujuan , Yang Yang (Michael) , Huang Wei , Zhao Qiang 
Published: October 2021

AbstractNowadays, the development of X‐ray imaging has promoted the demand for new‐type scintillators, among which low‐toxic manganese(II) complexes have attracted burgeoning research interest. Herein, a highly stable manganese(II) complex with peculiar five‐coordinated modes is reported, which exhibits strong yellow emission peaked at 583 nm originating from d‐d transition of Mn2+ with high photoluminescence quantum yield (PLQY) up to 93%. The five‐coordinated manganese(II) complex has been rarely reported so far which is an innovative spot in the field of photofunctional metal complex. Thanks to the high PLQY and relatively large stokes shift, the manganese(II) complex yields bright yellow emission under low‐dose X‐ray irradiation and delivers excellent linear response to X‐ray, highlighting its suitability for X‐ray contrast imaging. Based on this, highly resolved X‐ray imaging is successfully achieved that can meet the requirements of many application scenarios. In addition, this manganese(II) complex demonstrates excellent radiation hardness, humidity resistance, and heat stability, indicating the application potential of scintillators in harsh environments. This research not only provides guidance for the design and fabrication of highly luminescent manganese(II)‐based complexes, but also demonstrates the potential of manganese(II)‐based complexes as scintillators for X‐ray imaging technology.
A Carry‐On Kit Containing Electrospun Nanofibrous Affinity Membranes by Surface Grafting Phenylboronic Acid for Quantitative Enrichment of Nucleotides in Urine
Authors: Zhai Xinhui , Lin Lulu , Wang Yongxing , An Haoyu , Shen Weiyang , Chen Rong 
Published: October 2021

AbstractIt has great potential to develop a carry‐on kit for quantitatively enrich nucleotide biomolecules in biological urine. In this study, the electrospun nanofibrous membranes were fabricated on and tailored along the circular coverslips for 6‐well orifice plates with specific surface area. After hydrophilic modification by plasma, the orifice membranes were grafted with phenylboronic acids as functional groups by EDC‐NHS reaction. Various morphological characterization showed effective introduction of quantitative phenylboronic acid groups onto the surface of the membranes. The sampling and chromatographic conditions were optimized for quantitative enrichment of nucleotides in urine by the affinity membranes in the orifice plate well. The carry‐on kit containing the affinity membranes exhibit considerable sensitivity (LOD 5.0 ng mL−1) and quantification (recoveries: 78.5 %–93.1 %) for spiked nucleotides in urine. It is low‐cost, convenient, and has great potential for developing standard operation procedure of quantitative enrichment of nucleotides in complex uric matrix with controllable adsorption capacities.
Exact equilibrium distributions in statistical quantum field theory with rotation and acceleration: Dirac field
Authors: Palermo A. , Buzzegoli M. , Becattini F. 
Published: October 2021

Abstract
We derive the general exact forms of the Wigner function, of mean values of conserved currents, of the spin density matrix, of the spin polarization vector and of the distribution function of massless particles for the free Dirac field at global thermodynamic equilibrium with rotation and acceleration, extending our previous results obtained for the scalar field. The solutions are obtained by means of an iterative method and analytic continuation, which lead to formal series in thermal vorticity. In order to obtain finite values, we extend to the fermionic case the method of analytic distillation introduced for bosonic series. The obtained mean values of the stress-energy tensor, vector and axial currents for the massless Dirac field are in agreement with known analytic results in the special cases of pure acceleration and pure rotation. By using this approach, we obtain new expressions of the currents for the more general case of combined rotation and acceleration and, in the pure acceleration case, we demonstrate that they must vanish at the Unruh temperature.
Remarks on fermions in a dipole magnetic field
Authors: Murugan Jeff , Shock Jonathan P. , Slayen Ruach Pillay 
Published: October 2021

Abstract
This work is a continuation of our recent study of non-relativistic charged particles, confined to a sphere enclosing a magnetic dipole at its center [1]. In this sequel, we extend our computations in two significant ways. The first is to a relativistic spin-$$ \frac{1}{2} $$

1
2

fermion and the second concerns the interpretation of the physics. Whereas in [1] we speculated on the possibility of observing such condensed matter systems in the astrophysics of extreme magnetic sources such as neutron stars, the physical systems in this study are more down-to-earth objects such as a C60 fullerine enclosing a current loop. We unpack some of the details of our previous analysis for the spinless fermion on the dipole sphere and adapt it to solve the eigenvalue problem for the single-particle Dirac Hamiltonian. In the strong-field/small-radius limit, the spectrum of the spin-$$ \frac{1}{2} $$

1
2

Hamiltonian, like the spinless case, exhibits a Landau level structure in the |m| ≪ Q regime. It features a new, additional (approximately) zero-energy lowest Landau level which persists into the |m| < Q regime. As in the spinless system, the spectrum exhibits level-crossing as the strength of the magnetic field increases, with the wavefunctions localising at the poles in the strong-field/small-radius limit.
The qT and ∆ϕ spectra in W and Z production at the LHC at N3LL′+N2LO
Authors: Ju Wan-Li , Schönherr Marek 
Published: October 2021

Abstract
The production of weak gauge bosons, W± and Z, are at the core of the LHC precision measurement program. Their transverse momentum spectra as well as their pairwise ratios are key theoretical inputs to many high-precision analyses, ranging from the W mass measurement to the determination of parton distribution functions. Owing to the different properties of the W and Z boson and the different accessible fiducial regions for their measurement, a simple one-dimensional correlation is insufficient to capture the differing vector and axial-vector dynamics of the produced lepton pair. We propose to correlate them in two observables, the transverse momentum qT of the lepton pair and its azimuthal separation ∆ϕ. Both quantities are purely transverse and therefore accessible in all three processes, either directly or by utilising the missing transverse momentum of the event. We calculate all the single-differential qT and ∆ϕ as well as the double-differential (qT, ∆ϕ) spectra for all three processes at N3LL′+N2LO accuracy, resumming small transverse momentum logarithms in the soft-collinear effective theory approach and including all singlet and non-singlet contributions. Using the double-differential cross sections we build the pairwise ratios $$ {\mathrm{\mathcal{R}}}_{W^{+}/Z} $$

ℛ

W
+

/
Z

, $$ {\mathrm{\mathcal{R}}}_{W^{-}/Z} $$

ℛ

W
−

/
Z

, and $$ {\mathrm{\mathcal{R}}}_{W^{+}/{W}^{-}} $$

ℛ

W
+

/

W
−

and determine their uncertainties assuming fully correlated, partially correlated, and uncorrelated uncertainties in the respective numerators and denominators. In the preferred partially correlated case we find uncertainties of less than 1% in most phase space regions and up to 3% in the lowest qT region.
On Baer cones in $$\mathrm {PG}(3, q)$$
Authors: Napolitano Vito 
Published: October 2021

AbstractRecently, in Innamorati and Zuanni (J. Geom 111:45, 2020. 10.1007/s00022-020-00557-0) the authors give a characterization of a Baer cone of $$\mathrm {PG}(3, q^2)$$

PG
(
3
,

q
2

)

, q a prime power, as a subset of points of the projective space intersected by any line in at least one point and by every plane in $$q^2+1$$

q
2

+
1

, $$q^2+q+1$$

q
2

+
q
+
1

or $$q^3+q^2+1$$

q
3

+

q
2

+
1

points. In this paper, we show that a similar characterization holds even without assuming that the order of the projective space is a square, and weakening the assumptions on the three intersection numbers with respect to the planes.
Projective Metric Geometry and Clifford Algebras
Authors: Havlicek Hans 
Published: October 2021

AbstractEach vector space that is endowed with a quadratic form determines its Clifford algebra. This algebra, in turn, contains a distinguished group, known as the Lipschitz group. We show that only a quotient of this group remains meaningful in the context of projective metric geometry. This quotient of the Lipschitz group can be viewed as a point set in the projective space on the Clifford algebra and, under certain restrictions, leads to an algebraic description of so-called kinematic mappings.
The geometric Burge correspondence and the partition function of polymer replicas
Authors: Bisi Elia , O’Connell Neil , Zygouras Nikos 
Published: October 2021

AbstractWe construct a geometric lifting of the Burge correspondence as a composition of local birational maps on generic Young-diagram-shaped arrays. We establish its fundamental relation to the geometric Robinson-Schensted-Knuth correspondence and to the geometric Schützenberger involution. We also show a number of properties of the geometric Burge correspondence, specializing them to the case of symmetric input arrays. In particular, our construction shows that such a mapping is volume preserving in log-log variables. As an application, we consider a model of two polymer paths of given length constrained to have the same endpoint, known aspolymer replica. We prove that the distribution of the polymer replica partition function in a log-gamma random environment is a Whittaker measure, and deduce the corresponding Whittaker integral identity. For a certain choice of the parameters, we notice a distributional identity between our model and the symmetric log-gamma polymer studied by O’Connell, Seppäläinen, and Zygouras (2014).
Der Europäische MSM Internet Survey als Grundlage für die Präventionsarbeit in Deutschland für Männer, die Sex mit Männern haben
Authors: Marcus Ulrich , Schink Susanne B. 
Published: October 2021

Zusammenfassung
Hintergrund
Sexuelle Minderheiten sind in hohem Maße anfällig für sexuell übertragbare Infektionen (STI), psychische Probleme wie Depressionen und Suizidalität sowie für gesundheitliche und soziale Probleme, die mit Substanzkonsum assoziiert sind.

Ziel der Arbeit
Wir beschreiben ausgewählte Ergebnisse aus dem Europäischen MSM Internet Survey (EMIS) 2017, eine der größten Onlinebefragungen von Männern, die Sex mit Männern haben (MSM), und diskutieren deren Implikationen für die Prävention in Deutschland.

Material und Methoden
Das übergeordnete Ziel von EMIS-2017 war es, Daten für die Planung von HIV- und STI-Präventions- und -Behandlungsprogrammen zu erheben. Die Zielpopulation waren in Europa lebende MSM. Der Fragebogen enthielt Fragen zu Demografie, Morbiditäten, Verhalten, Bedarfen und Interventionen. Die deutschen Teilnehmer wurden von 10/2017 bis 01/2018 vor allem über 2 große Onlinedatingplattformen rekrutiert.

Ergebnisse und Diskussion
EMIS-2017 zeigt, dass MSM stark von psychischen Belastungen und STI betroffen sind. Jüngere MSM leiden verstärkt unter depressiven Störungen und Suizidalität, während bei älteren MSM der Konsum von Alkohol und anderen psychoaktiven Substanzen bedeutsam ist.
MSM sind von STI stärker betroffen als Heterosexuelle. Viele STI verursachen keine oder nur untypische Beschwerden, daher wird ein Screening auf der Basis einer Risikoeinschätzung favorisiert. Für einen Teil der STI gibt es bislang keine medizinischen und/oder Public-Health-Erkenntnisse, die für eine Behandlung asymptomatischer Infektionen sprechen. EMIS-2017 identifizierte Bedarfe nach Untergruppen in Bezug auf Wissenslücken zu HIV-Post- und HIV-Präexpositionsprophylaxe (PEP, PrEP), Erreichbarkeit durch Informations- und Präventionsangebote sowie unzureichende Nutzung dieser Angebote.