bluuebunny/crossref_metadata_2025_split huggingface dataset:
Returning to Learning: What are the academic development needs of mature and part-time students? What works to support and retain these students?
Authors: Frith Louise , Wilson Allia 
Published: March 2021

ÃÂ This paper considers issues around the support and retention of mature and part-time (MaP) students. It analyses the specific academic development needs of MaP students based on WengerÃ¢â¬â¢s model of learning (1998) which puts the academic learning needs of students into three broad categories; the first is academic confidence and learner identity, the second is the need for MaP students to integrate and build a sense of community and the third is for these students to overcome anxiety through practice and practical considerations. Then an Appreciative Inquiry (Cooperrider, Whitney and Stavros, 2008) approach is used to examine the extent to which the University of KentÃ¢â¬â¢s Student Learning Advisory Service (SLAS) supports MaP students through a programme of self-assessment of needs, one to one advice and targeted study skills sessions. The conclusion points to the positive responses received fromÃÂ MaP students about the programme but also acknowledges that more could be done; perhaps through reflection on studentsÃ¢â¬â¢ prior knowledge, a stronger emphasis on building social learning networks and the increased use of technology.ÃÂ Key words: mature and part-time students, identity, community, practice
Incidental Lingual Thyroid: A Case Report and Review of Literature
Authors: Narendrakumar Veerasigamani , Sampathkumar Geethalakshmi 
Published: March 2021

ABSTRACTThe presence of the thyroid gland outside its compartment is defined as ectopic thyroid. It is an abnormal embryological development. When present in the base of the tongue, it is lingual thyroid. We report this case of incidental lingual thyroid during routine clinical examination and highlight the importance of endoscopic examination in otorhinolaryngology.How to cite this article:Narendrakumar V, Sampathkumar G. Incidental Lingual Thyroid: A Case Report and Review of Literature. Int J Otorhinolaryngol Clin 2020;12(2):25–26.
The possible effect of coenzyme Q10 and captopril on acetaminophen-induced encephalopathy in rats: possible influence on autophagy, antioxidant and Na+/K+ ATPase
Authors: Galal Heba M. , Sayed Manal M. , Allah Eman S. H. Abd 
Published: March 2021

IntroductionInduction of autophagy could protect against acetaminophen (APAP)-induced hepatotoxicity; however, little is known about the role of autophagy in APAP-induced encephalopathy (APAP-E). This study aimed to evaluate the effects of coenzyme Q10 (CoQ10) and captopril on APAP-E.Material and methodsForty-eight rats were randomly allotted to 4 equal groups: control, an APAP-E, coenzyme Q10-treated (CoQ10-treated), and captopril-treated groups. Behavioral tests were conducted. Serum ammonia and total antioxidant capacity (TAC) and hippocampal Na+/K+ ATPase activity were measured. The expression levels of hippocampal microtubule-associated protein light chain 3 (LC3-II) and beclin-1 mRNA were detected using quantitative polymerase chain reaction (qPCR). General histological, immunohistochemical staining for glial fibrillary acid protein (GFAP) and electron microscopy (EM) of the hippocampus were performed.ResultsIn the APAP-E group, serum ammonia was increased significantly, hippocampal LC3-II and beclin-1 mRNA were elevated insignificantly, while serum TAC and the activity of hippocampal Na+/K+ ATPase were reduced significantly compared with the control group. APAP-E rats showed remarkable degenerative changes in CA1 pyramidal neurons in the form of electron-dense cytoplasm with ill-defined nuclei and accumulation of lysosomal structure-like dense bodies. Increased immunoreactivity of astrocytes for GFAP was observed. Treatment with either CoQ10 or captopril significantly reduced ammonia levels, increased hippocampal LC3-II and beclin-1 mRNA, increased serum TAC and Na+/K+ ATPase activity, and noticeably ameliorated the hippocampal neuronal changes. EM revealed restoration of the normal structure of pyramidal neurons. These effects were more obvious in CoQ10-treated than captopril-treated rats.ConclusionsCoQ10 and captopril have neuroprotective effects on APAP-E via enhancing LC3-II, beclin-1 mRNA expression, serum TAC level and hippocampal Na+/K+ ATPase activity.
Role of ADAMTS16 metalloproteinase in pathogenesis
of cryptorchidism
Authors: Gerszon Joanna , Kabziński Jacek , Kucharski Piotr , Majsterek Ireneusz , Niedzielski Jerzy K. 
Published: March 2021

IntroductionThe etiology of cryptorchidism is still not fully elucidated, but several hypotheses have been proposed. One of the latest concerns is the involvement of metalloproteinase ADAMTS16 in testis descent. The aim of this study was to evaluate both expression and occurrence of selected polymorphisms of metalloproteinase ADAMTS16 in patients diagnosed with cryptorchidism.Material and methodsThe study group consisted of 158 boys (mean age: 4.1 ±2.04 years) who underwent surgery due to undescended testis. Tissue samples from patients with cryptorchidism were obtained from the cremaster muscle, gubernaculum and hernial sac. The reference group consisted of 123 age-related subjects (mean age: 4.1 ±2.41 years) who had no cryptorchidism and underwent surgery for other reasons. Tissue samples from controls were obtained from the cremaster muscle and hernial sac.ResultsThe obtained data indicate that patients with undescended testis have significantly lower expression of Adamts16, especially in the gubernaculum. We also demonstrated a tendency that Adamts16 expression depends on the age of patients; the older the patient was, the higher was the observed expression of Adamts16. These studies also established that polymorphisms rs16875319, rs16875122, and rs58353460 in the Adamts16 gene are not a major determinant to develop cryptorchidism while rs16875054 is associated with increased risk.ConclusionsThese studies highlight ADAMTS16 involvement in cryptorchidism and confirm data obtained in animal models.
Mechanism of resistin-induced enhancement
of proliferation and migration of ovarian cancer cells
Authors: Pang Li , Li Xian-li 
Published: March 2021

IntroductionResistin, a novel hormone secreted by human adipocytes and mononuclear cells, is associated with obesity, insulin resistance, and inflammation. Recent studies showed that resistin plays a key role in ovarian cancer cells. In this study, we investigated the potential of resistin to regulate the proliferation and migration of ovarian cancer cells.Material and methodsA series of in vitro functional experiments were carried out to elucidate the role of resistin in ovarian cancer progression and the molecular mechanisms underlying its role.ResultsResistin enhanced the proliferation of human ovarian epithelial carcinoma cells (HO-8910) in a time- and dose-dependent manner (30–100 ng/ml). Furthermore, HO-8910 cells cultured in adipocyte-conditioned medium showed dramatically increased rates of proliferation. Resistin knockout during adipocyte culture attenuated the proliferation of HO-8910 cells treated with adipocyte-conditioned media, indicating that resistin may promote HO-8910 cell proliferation via the mechanistic target of a rapamycin (mTOR)-mediated signaling pathway. Resistin (30–100 ng/ml) also enhanced wound-healing rates in a time- and concentration-dependent manner. Co-culturing HO-8910 cells with adipocytes also increased the wound-healing rates. Resistin expression was inhibited by miR-124-1 transcriptional activity, and resistin-mediated HO-8910 cell migration was also regulated by miR-124-1. Furthermore, we also confirmed the role of resistin in promoting tumor growth in vivo.ConclusionsThese findings suggest that resistin may serve as an effective therapeutic target for ovarian epithelial carcinoma, especially in patients who are obese.
Association of vitamin D receptor and CYP2R1 mRNA expression with pulmonary tuberculosis
Authors: Li Hong-Miao , Li Ye , Zhang Gen-You , Shi Si-Jiu , Zhang Tian-Ping 
Published: March 2021

IntroductionThe vitamin D metabolic pathway has been shown to play a pivotal role in the pathogenesis of pulmonary tuberculosis (PTB), and vitamin D receptor (VDR) and CYP2R1 gene variation are known to affect vitamin D status. Hence, this study aimed to evaluate VDR and CYP2R1 mRNA expression in peripheral blood mononuclear cells (PBMCs) in PTB patients.Material and methodsWe measured VDR and CYP2R1 mRNA levels in 75 PTB patients and 63 healthy controls by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). The associations of VDR and CYP2R1 mRNA levels with clinical characteristics and laboratory indexes of PTB patients were also examined in this study.ResultsCompared to healthy controls, the VDR mRNA level was significantly higher, and the CYP2R1 mRNA level was significantly lower in PBMCs from PTB patients (p = 0.047, p = 0.008, respectively). The CYP2R1 mRNA level in PTB patients with drug-resistant, unilateral tuberculosis foci was significantly higher than that in PTB patients without these clinical characteristics (p = 0.005, p = 0.048, respectively). In addition, our results demonstrated that the VDR mRNA expression level was positively correlated with erythrocyte sedimentation rate (ESR) (p = 0.045), while the CYP2R1 mRNA level was negatively correlated with ESR in PTB patients (p = 0.020).ConclusionsAltered VDR and CYP2R1 mRNA expression levels among PTB patients suggest their involvement in this disease.
Long non-coding RNA HULC regulates growth and metastasis of human glioma cells via induction of apoptosis and inhibits cell migration and invasion
Authors: Ma Junfeng , Zhou Liang 
Published: March 2021

IntroductionThe long non-coding RNA HULC has been shown to be involved in the development of several human cancers. The present study was undertaken to investigate the regulatory role of lncRNA-HULC in growth and metastasis of human glioma.Material and methodsThe gene expression of lncRNA-HULC was estimated from the clinical glioma tissues and cell lines using RT-PCR. The proliferation of transfected cancer cells was determined with the help of cell counting kit-8 (CCK8). DAPI staining and dual annexin V-FITC/PI staining procedures were used for inferring the apoptosis of transfected cancer cells. Scratch-heal and transwell chamber assays were employed for the determination of migration and invasion of transfected cells. The expression of proteins of interest was studied by western blotting technique.ResultsThe results showed that lncRNA-HULC exhibits significantly (p < 0.05) higher expression in glioma tissues and cancer cells. The knockdown of lncRNA-HULC led to a marked decline in the proliferation of glioma cells through apoptotic induction which was accompanied by upregulation of Bax and downregulation of Bcl-2. Moreover, knockdown of lncRNA-HULC significantly (p < 0.05) suppressed the migration and invasion of cancer cells in vitro. The western blot analysis showed that lncRNA-HULC exerted its effects via modulation of the PI3K/AKT signaling pathway.ConclusionsThe study revealed the possibility of targeting the PI3K/AKT signaling pathway in glioma through transcriptional knockdown of lncRNA-HULC, which might be utilized for therapeutic purposes against human glioma.
FIB-4 index associated with mortality risk of patients with systemic lupus erythematosus: a large retrospective cohort study
Authors: Jin Ziyi , Feng Xuebing , Wang Dandan , Pan Wenyou , Liu Lin , Wu Min , Hu Huaixia , Ding Xiang , Wei Hua , Zou Yaohong , Qian Xian , Wang Meimei , Wu Jian , Tao Juan , Tan Jun , Da Zhanyun , Zhang Miaojia , Li Jing , Sun Lingyun 
Published: March 2021

IntroductionA considerable proportion of patients with systemic lupus ery­thematosus (SLE) have liver enzyme abnormalities. We evaluated whether fibrosis-4 (FIB-4) was associated with increased mortality of SLE patients.Material and methodsA multicenter retrospective cohort study was conducted based on medical records of first-admission SLE patients who were hospitalized during 1999–2009 in Jiangsu province. FIB-4 was estimated by age, platelet (PLT) count, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and FIB-4. A Cox model and a restricted cubic spline (RCS) model were used to estimate hazard ratio (HR) and 95% confidence interval (95% CI).ResultsDuring up to 15 years of follow-up, 226 deaths were observed among 2331 SLE patients. Increased overall mortality was associated with abnormal groups of PLT, ALT, AST, and high FIB-4 (≥ 1.92), with adjusted HRs (95% CI) of 1.58 (1.19–2.11), 1.54 (1.14–2.07), 1.58 (1.17–2.12), and 1.88 (1.42–2.50), respectively. Moreover, significant dose-response relationships were found between mortality of SLE and those indexes, and it was nonlinear for PLT (p < 0.001), ALT (p = 0.046) and FIB-4 (p < 0.001), but not AST (p = 0.109). In cause-specific analyses, high FIB-4 index was directly associated with death from liver failure and indirectly associated with other death from infection and neuropsychiatric impairment. We found no significant differences of areas under curves (AUCs) between FIB-4 index and the disease activity index score of SLE.ConclusionsThis is the first report to describe the nonlinear association between FIB-4 index and increased mortality of SLE patients. The FIB-4 index may be used as an independent prognostic indicator for SLE patients.
Long non-coding RNA SENCR alleviates endothelial‑to‑mesenchymal transition via targeting miR‑126a
Authors: Lou Chuang , Li Tao 
Published: March 2021

IntroductionLong non-coding RNAs (lncRNAs) constitute a growing class of non-coding genes with diverse cellular function. Recent studies have reported that lncRNA smooth muscle and endothelial cell-enriched (SENCR) was associated with the phenotype switch of vascular smooth muscle cells and participated in vascular homeostasis. However, the potential role of SENCR in endothelial-to-mesenchymal transition (EndMT) and the underlying mechanism remain unknown.Material and methodsHuman carotid plaque samples and human coronary endothelial cells (HACECs) were collected to examine the expression of SENCR. Quantitative PCR and immunoblots were performed to evaluate the expression of SENCR and miR-126a in HACECs in response to TGF-b1 and transfected with small interfering RNA.ResultsWe found that SENCR was significantly decreased in carotid plaques as compared to normal carotids. Knockdown of SENCR in HACECs aggravated the expression of smooth muscle markers a-SMA and calponin induced by TGF-b1 but repressed the expression of endothelial markers platelet/endothelial cell adhesion molecule 1 (PECAM1) and VE-cadherin down-regulated by TGF-b1. Through bioinformatic analysis and Luciferase assay, miR-126a was identified as the direct target of SENCR. Further mechanistic experiments revealed that overexpression of miR-126a bound to the 3˘UTR region of SMURF2 and inhibited the expression of SMURF2, which was considered as the negative regulator of TGF-b/Smad signaling. Finally, overexpression of miR-126a did not restore the decreased expression of the smooth muscle markers a-SMA and calponin under the condition of SMURF2 depletion, suggesting that the effect of miR-126a on EndMT progression is SMURF2 dependent.ConclusionsSENCR alleviates TGF-b-induced EndMT and sponges miR-126a expression via direct inhibition of the negative regulator of TGF-b/Smad signaling SMURF2.
Resveratrol promotes apoptosis and G2/M cell cycle arrest of fibroblast-like synoviocytes in rheumatoid arthritis through regulation of autophagy and the serine-threonine kinase-p53 axis
Authors: Li Shu , Du Jinfeng , Gan Haina , Chen Jinwei , Zhou Yang , Tian Jing , Ling Guanghui , Li Fen 
Published: March 2021

IntroductionResveratrol, a polyphenol extracted from many plant species, has emerged as a promising pro-apoptotic agent in various cancer cells. However, the role of resveratrol in cell proliferation and apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis (RA-FLS) is not fully understood. The study was aimed at elucidating the role of resveratrol in cell proliferation and apoptosis of RA-FLS and the underlying molecular mechanism.Material and methodsCultured RA-FLSs were subjected to tumour necrosis factor  (TNF-). The cell proliferation was measured by Cell Counting Kit-8 assay. Cell apoptosis and cell cycle of RA-FLSs were determined by flow cytometry. The levels of apoptosis or autophagy or cell cycle-related protein were detected by immunoblot analysis.ResultsIn our study, we confirmed that resveratrol reversed TNF- mediated cell proliferation in RA-FLS. Meanwhile, resveratrol blocked cells at the G2/M stage and reduced the ratio of S phase cells through upregulation of p53 and consequently led to apoptotic cell death. Quite interestingly, we found that resveratrol reversed TNF--induced autophagy. Inhibition of autophagy by resveratrol or autophagy inhibitor or Beclin-1 siRNA suppressed TNF- mediated cell survival and promoted cell apoptosis. However, the autophagy inducer rapamycin (RAPA) reversed the effect of resveratrol on autophagy and cell proliferation. Mechanistic studies revealed that resveratrol inhibited the activation of the phosphoinositide 3-kinases/serine-threonine kinase (PI3K/AKT) pathway. Inhibition of PI3K/AKT pathway by inhibitor LY294002 or resveratrol increased the expression of p53 and decreased the expression of cycle protein (cyclin B1), which further led to block cells in the G2/M arrest.ConclusionsOur preliminary study indicated that resveratrol may suppress RA-FLS cell survival and promote apoptosis at least partly through regulation of autophagy and the AKT-p53 axis.
ANALISIS PENGARUH PIUTANG DAN PENJUALAN KREDIT TERHADAP PROFITABILITAS PERUSAHAAN TAHUN 2016-2018 (STUDI KASUS CV DAVIN JAYA KARIMUN)
Authors: Yusmalina  , Novita Sari Sinta , Haqiqi Fauzan , Tambunan Verawaty 
Published: March 2021

CV. Davin Jaya merupakan perusahaan dagang yang bergerak di bidang distribusi makanan dan minuman serta kebutuhan pokok rumah tangga. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh baik secara simultan maupun parsial antara perputaran piutang dan penjualan kredit terhadap profitabilitas CV Davin Jaya Karimun, yang diukur dari variabel-variabel perputuran piutang dan penjualan kredit. Penelitian ini menggunakan metode kualitatif dengan menggunakan data sekunder. Populasi dalam penelitian ini adalah laporan keuangan CV Davin Jaya Karimun dan sebanyak 36 sampel penelitian. Adapun teknik analisis data yang digunakan adalah statistik deskripstif dan regresi linear berganda.
ANALISIS PENGARUH SIMPANAN ANGGOTA DAN PINJAMAN ANGGOTA TERHADAP PEROLEHAN SISA HASIL USAHA (STUDI KASUS PADA KSP KREDIT UNION JEMBATAN KASIH TANJUNG BALAI KARIMUN PERIODE TAHUN 2016-2018)
Authors: Haqiqi Fauzan , Nanda Alkausar Raja , Yusmalina  , Laily Azmia 
Published: March 2021

Koperasi Simpan Pinjam Credit Union Jembatan Kasih adalah suatu koperasi yang bergerak dibidang simpan pinjam. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh baik secara parsial maupun secara simultan antara simpanan anggota dan pinjaman anggota terhadap perolehan SHU pada KSP Credit Union Jembatan Kasih, yang diukur dari variabel-variabel simpanan anggota dan pinjaman anggota. Penelitian ini menggunakan metode kuantitatif yang mengguunakan data sekunder. Data akan dianalisa dengan metode statistik deskriptif dan regresi linier berganda, dengan mengunakan SPSS 22. Pada penelitian ini populasi yang diambil adalah laporan keuangan CUJK Tanjung Balai Karimun tahun 2016-2018 dengan sampel sebanyak 33. Hasil analisa regresi berganda menunjukan bahwa variabel yang terdiri dari Simpanan Anggota (X1), Pinjaman Anggota (X2) secara parsial tidak berpengaruh terhadap SHU (Y) KSP Credit Union Jembatan Kasih. Namun, secara simultan memiliki pengaruh yang signifikan terhadap SHU (Ys). Berdasarkan uji analisis determinasi diperoleh angka R2 sebesar 0,056 atau 5,6%. Berdasarkan uji t pada variabel simpanan anggota terhadap SHU diperoleh nilai thitung 0,004 < ttabel 2,042 dan pada variabel pinjaman anggota terhadap SHU diperoleh nilai thitung 1,140 < ttabel 2,042. Berdasarkan uji F diperoleh nilai Fhitung 0,897 dengan nilai sig 0,418 maka nilai sig 0,418 > 0,05.
GLIOMAS, TUMORES MALIGNOS QUE SURGEM NO SISTEMA NERVOSO
Authors: Santos André Luiz dos 
Published: March 2021

Gliomas são os tumores cerebrais primários mais frequentes, representando mais de 70% de todas as neoplasias do Sistema Nervoso Central. Tanto o diagnóstico como a classificação destes tumores são baseados nas características histopatológicas que, por vezes, são difíceis de definir. Apesar dos avanços na neurocirurgia, quimioterapia e radioterapia, o prognóstico dos doentes com gliomas continua muito reservado. Nas últimas duas décadas, o tratamento para os gliomas de alto grau envolveu uma abordagem multidisciplinar, que se baseava em resseção cirúrgica máxima, quando possível, seguida de radioterapia e quimioterapia. Esta constitui a abordagem terapêutica convencional, com um grande número de ensaios clínicos que revelaram na sua maioria pequenas melhorias que não são satisfatórias. Sendo assim, este estudo tem como objetivo realizar uma revisão bibliográfica para coletar informações sobre o glioma, assim como, os avanços nos diagnósticos e tratamentos. Na atualidade as opções terapêuticas disponíveis no tratamento de gliomas, (que incluem, em linhas gerais, cirurgia, RT e QT), ainda não são suficientemente eficazes no controle da progressão da doença. Estudos experimentais demonstraram que a combinação de terapia antiangiogênica, baseada na ruptura de vasos sanguíneos tumorais, com quimioterapia convencional gera resultados encorajadores.
AFETIVIDADE E APRENDIZAGEM — PERCEPÇÕES DO PROFESSOR NO ENSINO FUNDAMENTAL I
Authors: Oliveira Maria Luiza Sobreira de 
Published: March 2021

A presente pesquisa é resultado da reflexão sobre como os professores alfabetizadores percebem a afetividade na sua prática, a importância e relação que estabelecem entre afetividade e aprendizagem. O público-alvo foi um grupo de 15 professores de três escolas de um município da Grande São Paulo. Considera-se a partir das análises que os professores percebem a afetividade como essencial, no processo de alfabetização, tanto que, pontuaram que deveria ser considerada a partir da escolha da classe. O professor acredita que a afetividade se relaciona com a cognição e que essa relação se dá por meio do vínculo nas relações: professor-aluno; aluno-aluno, aluno-conhecimento, e pela motivação. A importância apontada para a afetividade, na prática, mais uma vez se relaciona à motivação que impulsiona o aluno durante o processo de aprendizagem. Os relatos nas entrevistas, demonstram nas diversas situações que, quando se há respeito, compreensão, diálogo e principalmente quando os aspectos afetivos e cognitivos do sujeito são considerados no processo de aprendizagem, a alfabetização acontece de forma satisfatória, no entanto, nos chama atenção alguns professores apontarem para a afetividade como importante para manter a sala de aula disciplinada, esse dado nos leva a refletir que em muitas situações o professor pode utilizar a afetividade como meio de controle de seus alunos e não como favorecedora da aprendizagem.