bluuebunny/crossref_metadata_2025_split huggingface dataset:
A practical methodology to perform global sensitivity analysis for 2D hydrodynamic computationally intensive simulations
Authors: Alipour Saba Mirza , Engeland Kolbjørn , Leal Joao 
Published: September 2021

Abstract
Sensitivity analysis is a commonly used technique in hydrological modeling for different purposes, including identifying the influential parameters and ranking them. This paper proposes a simplified sensitivity analysis approach by applying the Taguchi design and the ANOVA technique to 2D hydrodynamic flood simulations, which are computationally intensive. This approach offers an effective and practical way to rank the influencing parameters, quantify the contribution of each parameter to the variability of the outputs, and investigate the possible interaction between the input parameters. A number of 2D flood simulations have been carried out using the proposed combinations by Taguchi (L27 and L9 orthogonal arrays) to investigate the influence of four key input parameters, namely mesh size, runoff coefficient, roughness coefficient, and precipitation intensity. The results indicate that the methodology is adequate for sensitivity analysis, and that the precipitation intensity is the dominant parameter. Furthermore, the model calibration based on local variables (cross-sectional water level) can be inaccurate to simulate global variables (flooded area).
Enhancing the resilience of the rainwater for drinking (RFD) system through systematic monitoring: a case study at the Ly Nhan rural hospital in Vietnam
Authors: Lee Hakyung , Son Tran Hoai , Dzung Dao Anh , Lee Jongkook , Han Mooyoung , Anh Nguyen Viet 
Published: September 2021

Abstract
Many rainwater harvesting systems have been installed and operated to supply drinking water to rural regions. However, they often lacked the management method to supply safe and reliable drinking water. The current practice of operating rainwater harvesting systems did not have systematic monitoring as the basis of reliable operation so that the operators did not have confidence in their operation. To overcome these limitations, a rainwater for drinking (RFD) system has been suggested which was to produce drinking water by adding the proper treatment processes and setting up the proper operational mode. This study aimed to evaluate stable regular monitoring results from a pilot RFD system at a local hospital in Vietnam. Water quality and quantity were monitored by the trained local operator on a quarterly and weekly basis. The raw dataset was then shared with the study team by uploading into an open data access platform, from where the technical support was provided to prevent the provision of unsafe water to users. Ultimately, employing systematic monitoring would help to enhance the resilience of the RFD system, contributing to resolving the drinking water issue in rural areas of developing countries, aiming at the achievement of Sustainable Development Goal 6.
Experimental and numerical investigation of flow over a spillway bend with different combinations of permeable spur dikes
Authors: Yang Jinmeng , Shen Zhenzhong , Zhang Jing , Teng Xiaomin , Zhang Wenbing , Dai Jie 
Published: September 2021

Abstract
In this paper, the effects of different combinations of permeable spur dikes installed in the bend section of spillway on flow characteristics and energy dissipation rate were experimentally and numerically investigated. The results indicate that the permeable spur dikes installed in the spillway bend appreciably contributes to the improvement on the water surface uniformity, and the water surface uniformity can reach 90.13% with three permeable spur dikes installed in the bend. The permeable spur dike can lead to different degrees of decrease in the time-averaged longitudinal velocity in each zone of spillway bend. Different from previous study, no circulation zone is formed upstream and downstream of permeable spur dike due to the presence of permeable holes, and the flow upstream of permeable spur dikes could be divided into three distinctly different flow modes according to dye tracing. The presence of permeable spur dikes causes the concentration of TKE zone at concave bank of the spillway bend, except for TKE zone immediately next to the bottom plate. The TKE first increases and then decreases with the increase in the vertical distance from the bottom plate of the spillway bend, exhibiting a typical parabolic distribution. The energy dissipation rate in the spillway bend with permeable spur dike was calculated using a modified integral method, and the dissipation rate can reach as high as 21.08% with three spur dikes installed in the bend.
Unlocking the potential of biosynthesized zinc oxide nanoparticles for degradation of synthetic organic dyes as wastewater pollutants
Authors: Gangwar Jaya , Sebastian Joseph Kadanthottu 
Published: September 2021

AbstractThe azo dyes released into water from different industries are accumulating in the water bodies and bioaccumulating within living systems thereby affecting environmental health. This is a major concern in developing countries where stringent regulations are not followed for the discharge of industrial waste into water bodies. This has led to the accumulation of various pollutants including dyes. As these developing countries also face acute water shortages and due to the lack of cost-effective systems to remove these pollutants, it is essential to remove these toxic dyes from water bodies, eradicate dyes, or generate fewer toxic derivatives. The photocatalysis mechanism of degradation of azo dyes has gained importance due to its eco-friendly and non-toxic roles in the environment. The zinc nanoparticles act as photocatalysts in combination with plant extracts. Plant-based nanoparticles over the years have shown the potential to degrade dyes efficiently. This is carried out by adjusting the dye and nanoparticle concentrations and combinations of nanoparticles. Our review article considers increasing the efficiency of degradation of dyes using zinc oxide (ZnO) nanoparticles and understanding the photocatalytic mechanisms in the degradation of dyes and the toxic effects of these dyes and nanoparticles in different tropic levels.
Mimicking LysC Proteolysis by ‘Arginine Modification-cum-Trypsin
Digestion’: Comparison of Bottom-up & Middle-down Proteomic
Approaches by ESI Q-TOF MS
Authors: Pandeswari P. Boomathi , Chary R. Nagarjuna , Kamalanathan A.S. , Prabhakar Sripadi , Sabareesh Varatharajan 
Published: September 2021

Background:
Middle-down (MD) proteomics is an emerging approach for reliable identification
of post-translational modifications and isoforms, as this approach focuses on proteolytic
peptides containing > 25-30 amino acid residues (a.a.r.), which are longer than typical tryptic peptides.
Such longer peptides can be obtained by AspN, GluC, and LysC proteases. Additionally,
some special proteases were developed specifically to effect MD approach, e.g., OmpT, Sap9, etc.
However, these proteases are expensive. Herein we report a cost-effective strategy ‘arginine modification-
cum trypsin digestion’, which can produce longer tryptic peptides resembling LysC peptides
derived from proteins.

Objective::
The aim of this study is to obtain proteolytic peptides that resemble LysC peptides by using
'trypsin', which is a less expensive protease.

Methods:
This strategy is based on the simple principle that trypsin cannot act at the C-termini of
those arginines in proteins, whose sidechain guanidine groups are modified by 1,2-cyclohexanedione
or phenylglyoxal.

Results:
As a proof of concept, we demonstrate this strategy on four models: β-casein (bovine), β-
lactoglobulin (bovine), ovalbumin (chick) and transferrin (human), by electrospray ionization-mass
spectrometry (ESI-MS) involving hybrid quadrupole time-of-flight. From the ESI-MS of these
models, we obtained several arginine modified tryptic peptides, whose lengths are in the range of
30-60 a.a.r. The collision induced dissociation MS/MS characteristics of some of the arginine modified
longer tryptic peptides are compared with the unmodified standard tryptic peptides.

Conclusion:
The strategy demonstrated herein this proof-of-concept study is not only useful to obtain
longer tryptic peptides that mimic LysC proteolytic peptides, but also facilitates in enhancing
the probability of missed cleavages by the trypsin. Hence, this method aids in evading the possibility
of obtaining very short peptides that are <5-10 a.a.r. Therefore, this is indeed a cost-effective alternative/
substitute for LysC proteolysis and, in turn, for those MD proteomic studies that utilize
LysC. Additionally, this methodology can be fruitful for mass spectrometry-based de novo protein
and peptide sequencing.
Design, Synthesis, and Docking Studies of Thioimidazolyl Diketoacid
Derivatives Targeting HIV-1 Integrase
Authors: Zarghi Afshin , Karimi Nafiseh , Roudsari Rouhollah Vahabpour , Hajimahdi Zahra 
Published: September 2021

Background:
Integrase enzyme is a validated drug target to discover novel structures as
anti-HIV-1 agents.

Objective:
This study aimed at developing a novel series of thioimidazolyl diketoacid derivatives
characterizing various substituents at N-1 and 2-thio positions of the central ring as HIV-1integrase
inhibitors.

Methods:
In this study, eighteen novel thioimidazolyl DKA derivatives were synthesized in a fivestep
parallel procedure and tested in vitro for the inhibition of both IN ST reaction and the singlecycle
HIV-1 replication in HeLa cell culture.

Results:
The obtained molecules were evaluated using the enzyme assay, displaying promising integrase
inhibitory activity with IC50 values ranging from 0.9 to 7.7 mM. The synthesized compounds
were also tested for antiviral activity and cytotoxicity using HeLa cells infected by the single-cycle
replicable HIV-1 NL4-3.

Conclusion:
The most potent compound was found to be 18i with EC50 = 19 μM, IC50 = 0.9 μM,
and SI = 10.5. Docking studies indicated that the binding mode of the active molecule is well aligned
with the known HIV-1integrase inhibitor.
Recent Patents on Preparation Methods and Mechanical Stability of Superhydrophobic Surface
Authors: Li Zhaolong , Liu Yingtao 
Published: September 2021

Background:
Superhydrophobic surfaces have unique wettability and have shown
broad application prospects in many fields, such as self-cleaning and lubrication drag reduction.
However, the superhydrophobic surfaces are severely restricted by their poor mechanical stability
in practical application, and the mechanical stability of the superhydrophobic surface is always
affected by different preparation methods. Therefore, people pay more attention to the preparation
methods of superhydrophobic surfaces.

Objective:
The study aims to improve the mechanical stability of the superhydrophobic surface
and expand the application fields of the superhydrophobic surfaces; preparation methods of the
superhydrophobic surface have been continuously improved.

Methods:
This paper reviews various representative patents and papers on preparation methods of
the superhydrophobic surface at home and abroad.

Results:
In this review, the basic methods of preparing superhydrophobic surfaces were introduced,
and three typical methods were summarized, such as etching method, coating method, and
sol-gel method, then their advantages and disadvantages were discussed. In combination with the
latest research progress, it is proposed that the use of environmentally friendly low surface energy
modifiers and the use of the one-step method to prepare superhydrophobic surfaces are the future
development trends. Aiming at the problem of the mechanical stability of superhydrophobic surfaces,
the instability mechanism and stability evaluation methods of superhydrophobic surfaces
under mechanical action are reviewed, and three basic methods to improve the mechanical stability
of superhydrophobic surfaces are proposed.

Conclusion:
The optimization of the preparation method of the superhydrophobic surface is beneficial
to improve the mechanical stability of the superhydrophobic surface and expand the application
prospect of the superhydrophobic surfaces in various fields. More patents and papers on the
superhydrophobic surface will be invented later.
Evaluation of Erectile Dysfunction in Nonobese, Nondiabetic Men with Obstructive Sleep Apnea
Authors: Scoralick Ana Carolina D. , Júnior Alonço da C. Viana , Cavalcanti André L. , dos Santos Ana Paula C. , Neves Denise D. , Melo Maria Helena A. 
Published: September 2021

Background:
Erectile Dysfunction (ED) has affected people suffering from Obstructive Sleep Apnea Syndrome (OSAS) and multiple studies have confirmed this correlation.

Objective:
The objective of the is to identify the association between ED and Obstructive Sleep Apnea (OSA) in nonobese, nondiabetic men based on the International Index of Erectile Function (IIEF).

Methods:
This retrospective cross-sectional study included 143 nonobese, nondiabetic men with OSA (age, ≥20 years) who visited the Sleep Outpatient Clinic of the Otorhinolaryngology Department at Hospital Naval Marcílio Dias from May 2017 to August 2018. Patient age, body mass index (BMI), drinking, smoking, laboratory diagnosis of hypogonadism based on total testosterone levels, and sleep parameters (e.g., apnea–hypopnea index, rapid eye movement density, and minimum Oxygen Saturation [SatO2]) were considered. Analysis of variance was used to evaluate means. The chi-squared test and Fisher’s exact test were used to compare variables and Person’s correlation coefficient was used to analyze numerical variables.

Results:
The mean minimum SatO2 was 78.89%, and 46% of patients exhibited minimum SatO2 <80%. Moreover, minimum SatO2 of <80% and increasing age were associated with ED complaints based on IIEF scores,. A laboratory diagnosis of hypogonadism was associated with increased BMI, and aging was associated with SatO2.

Conclusion:
The results of the study revealed that oxygen desaturation of <80% was related to complaints of ED from the IIEF. Moreover, a relationship between laboratory hypogonadism and increased BMI values, aging, and oxygen desaturation has been demonstrated. Therefore, we recommend polysomnography in patients with ED complaints.
The Effect of Simulation-based Training on Athletic Performances among Female Basketball Players
Authors: Javanmardi Zahra , Jahromi Maryam K. , Hemmatinafar Mohammad , Knechtle Beat , Nikolaidis Pantelis T. 
Published: September 2021

Background:
The effectiveness of simulation-based training has been examined in various sports. However, considering the effect of gender and sport on training, it would be interesting to evaluate simulation-based training in female basketball.

Objective:
The purpose of the study was to examine the effect of simulation-based training on physical fitness and performance indices in female basketball players.

Methods:
Sixteen female semi-professional basketball players were randomly assigned to experimental (n=8; age, 25±2 years; weight, 62±9 kg; height, 167±8 cm) or control (n=8; age, 24±1 years; weight, 57±9 kg; height, 170±8 cm) groups. The experimental group participated in a six week basketball simulation training program including running with different speeds (jogging to sprinting), agility, jumping, and shuffling. Both groups performed the Cooper 12 min run, line drill, an adjusted T-test, 20 ms print, the Sargent vertical jump and basketball exercise simulation test before and after six weeks of the study period. Control and experimental groups performed typical basketball training, three times weekly. The overall training volume was similar for both groups.

Results:
The perceived exertion was higher in the simulation-based training than control (p<0.05) group. The findings of this study indicated a significant increase in VO2 max (p=0.001), anaerobic power (p=0.009), explosive leg strength (p=0.036), and total distance covered in basketball exercise simulation test (p=0.001) and decrease of the meantime of one round of basketball exercise simulation test (p=0.001) in the simulation training compared to the control group.

Conclusion:
Generally incorporation of the simulation-based training in conditioning programs is recommended for improving aerobic, anaerobic and leg explosive strength of basketball players.
ENTRE POBREZA Y VIOLENCIA: ¿CÓMO AFECTAN LOS ESTRESORES DIARIOS Y LA VIOLENCIA A ADOLESCENTES EN ZONAS DE GUERRA?
Authors: Mels Cindy 
Published: September 2021

Se ha establecido científicamente que la violencia sufrida en situaciones de guerra afecta negativamente al funcionamiento psicológico de las víctimas, no obstante, se supone que es el conjunto de varios factores de riesgo y factores protectores los que determinan las reacciones concretas. Este artículo se enfocará en dos factores de riesgo –la exposición a eventos violentos y los estresores diarios– y su relación con conductas internalizadas (depresión y ansiedad) en adolescentes viviendo en una zona de guerra. A través de un muestreo por conglomerados comprendiendo 13 colegios en 4 zonas seleccionadas en Ituri, una provincia en el noreste de la República Democrática del Congo, se encuestan 991 alumnos (13 a 21 años) por medio de cuestionarios de auto-informe, revelando datos sobre las variables sexo, edad, exposición a la violencia, estresores diarios, conductas internalizadas y externalizadas. Se encontró que los adolescentes varones resultaron más expuestos a la violencia que las adolescentes mujeres. La exposición a eventos violentos también se diferenció según la edad, en ambos sexos. A su vez, los adolescentes mayores, tanto varones como mujeres, reportaron más estresores diarios que sus pares de menor edad. Un efecto de interacción entre la exposición a la violencia y estresores diarios predijo comportamientos internalizados a medida que ambas variables se acumulaban. Además, las adolescentes mujeres, mostraron más conductas internalizadas bajo la acumulación de estresores diarios que los adolescentes varones. Concluimos que los estresores diarios están asociados con mayores niveles de conductas internalizadas, sobre todo en adolescentes mujeres, y que la exposición a la violencia aumenta el efecto. A pesar de la violencia sufrida, la reducción de estresores diarios en la vida de adolescentes afectados por la guerra, podría promover su resiliencia y minimizar en cierta medida los síntomas psicológicos causados por el estrés acumulado durante la guerra.
LA REGULACIÓN AFECTIVA EN LA CONFORMACIÓN DE LA PERSONALIDAD. Estudio en escolares de 5 a 8 años
Authors: Miller Delfina 
Published: September 2021

Este trabajo profundiza, desde la perspectiva psicoanalítica, en la regulación afectiva y su incidencia en la organización de la personalidad, a partir de una investigación tanto conceptual como empírica. Se utilizó un diseño cuanti-cualitativo, sobre una muestra de 82 niños montevideanos, provenientes de tres medios socioeconómicos diferentes (alto, medio, bajo), La media de edad fue 6,2 años, con una prevalencia del 64% de varones. En la muestra se evidenció una alta prevalencia (18,9%) de niños con disregulación, provenientes en su mayoría del medio socioeconómico más carenciado (78,5%), de familias monoparentales y con antecedentes psiquiátricos. Según este estudio, la disregulación se asocia a importantes alteraciones en el desarrollo especialmente sueño, aprendizaje, adquisición de hábitos y empatía, generando dificultades en todas las áreas de desarrollo. Los niños con disregulación afectiva evidencian muy escasos afectos positivos y prácticamente no muestran miedo ni tristeza, tanto en sus juegos como en sus reacciones psicofisiológicas.
PROPIEDADES PSICOMÉTRICAS DE UNA PRUEBA EXPERIMENTAL DE DICTADO DE PALABRAS PARA LA EVALUACIÓN DE LA ORTOGRAFÍA EN ESCOLARES URUGUAYOS
Authors: Cuadro Ariel , Costa Ball Daniel , Palombo Ana Laura , Von Hagen Alexa 
Published: September 2021

Se presenta el desarrollo de una prueba de dictado de palabras (TEO-D) para la evaluación del nivel ortográfico de escolares de segundo a sexto grado de primaria, con el objetivo de contribuir a las prácticas educativas y a la valoración neuropsicológica y psicopedagógica de las dificultades en lenguaje escrito. La prueba se construyó a partir de la revisión y análisis de palabras frecuentes de nuestro medio, que contienen la alternancia del grafema b y v para representar el fonema /b/, los grafemas j y g para la representación del sonido /j/, las palabras, que pueden escribirse con ll o y, las que contienen el grafema h para el que no hay fonema y los grafemas c y s, que representan el sonido /s/. Se examina la estructura factorial, la fiabilidad y la validez de la prueba, que fue aplicada a una muestra de 488 alumnos de Montevideo, seleccionados mediante muestreo por conveniencia, entre dos colegios de educación privada de nivel socioeconómico medio bajo y medio alto. El análisis factorial confirmatorio, utilizando el programa NOHARM de un modelo de factor único, indica un ajuste adecuado a una estructura unidimensional, obteniendo una muy buena fiabilidad de consistencia interna en la muestra total y por curso.
ESTILOS PARENTALES, PARENTALIDAD POSITIVA Y FORMACIÓN DE PADRES
Authors: Capano Álvaro , Ubach Andrea 
Published: September 2021

El presente trabajo surge como una inquietud de los autores, (integrantes de una ONG que se dedica al trabajo con niños y adolescentes que han sufrido la vulneración de algunos de sus derechos) por revisar en un rápido recorrido los desarrollos conceptuales que nos parecen más relevantes sobre los estilos educativos parentales y las posibles consecuencias del ejercicio de uno u otro en niños y/o adolescentes. Además, el trayecto realizado nos ha permitido reflexionar sobre algunos conceptos, dejar planteadas algunas preguntas y pensar sobre concepciones educativas alternativas, para llegar a la conclusión en última instancia de la relevancia que adopta la formación de padres, no como una posibilidad remota y aislada, sino como un camino necesario a recorrer por instituciones educativas, sociales y sanitarias, públicas y privadas.
Analisis Pengaruh Kebijakan Pembelajaran Jarak Jauh (PJJ) Akibat Dampak Pandemik Covid-19 Terhadap Motivasi Belajar Peserta Didik
Authors: Septiani Indri , Samputra Palupi Lindiasari 
Published: September 2021

Penelitian ini bertujuan untuk 1) Mengetahui perbedaan metode pembelajaran Ceramah Plus dan metode pembelajaran Discovery Learning terhadap hasil belajar peserta didik, keaktifan peserta didik dalam bertanya, pengumpulan tugas peserta didik dan kehadiran peserta didik dalam belajar pada saat PJJ, 2) Menganalisis efektifitas metode pembelajaran yang digunakan untuk meningkatkan motivasi belajar peserta didik pada saat PJJ, 3) Menganalisis strategi metode pembelajaran dalam meningkatkan motivasi belajar peserta didik pada saat PJJ. Jenis penelitian ini quasi experiment. Populasi penelitian adalah sebanyak 50 siswa dilakukan secara purposive sampling. Sampel penelitian merupakan sampel yang sama dengan dua perlakuan. Data yang diperoleh dianalisis serta diuji dengan statistik Uji Sign Test. Hasilnya sebagai berikut, 1) Terdapat perbedaan antara nilai hasil ulangan, daftar kehadiran, keaktifan bertanya, dan pengumpulan tugas dengan menggunakan metode belajar Ceramah Plus dan Discovery Learning, 2) Kedua metode belajar tersebut memiliki kefektifan masing-masing saat diterapkan, Ceramah Plus lebih efekif dalam kehadiran dan keaktifan bertanya sedangkan Discovery Learning lebih efektif dalam meningkatkan nilai hasil ulangan dan pengumpulan tugas sedangkan 3) Metode Discovery Learning merupakan metode yang paling baik untuk meningkatkan motivasi belajar peserta didik pada saat PJJ.