bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Linear Regression Analysis in Minitab and Fuzzy Logic in Matlab as Tools for Calculating Oyster Mushroom Yields at Thara Farm, Ciawi District, Bogor Regency.
Authors: Sidik Djabar Sidik , Elan Nurul Paozan  , Naufal Syifa Abdul Karim  , Fisrawati  
Published: January 2025

Indonesia is a tropical country rich in biodiversity, with a predominance of flora and fauna compared to other countries with similar climates, one example being mushrooms. Mushrooms are a type of fungi that thrive in temperatures ranging from 22-28°C, humidity levels of 70-90%, and lighting between 85-540 lux. In mushroom cultivation, farmers face various challenges, such as unstable yields at certain times. Therefore, this study aims to identify the primary factors affecting the stability of mushroom yields at PT Tharam. According to expert data, during the period from July to December, harvests can reach up to 600 kg per day, while in January to June, yields can drop to as low as 200 kg. Through correlation and regression analysis, it has been determined that the factors influencing the increase and decrease of mushroom yields at PT Tharam include irrigation intensity, nutrient application, temperature, humidity, rainfall, and pest attacks on mushrooms.Keywords: Oyster Mushroom; Temperature; Lighting; Watering; Humidity
The Welding Defect Analysis on ASTM A106 Grade B with Inconel 82 Using Metallography Test and Microhardness Test
Authors: Muliawan Arief , Ilmianih Rizki 
Published: January 2025

Inspeksi pengelasan merupakan praktik penting untuk menilai integrasi struktur dan komponennya dalam banyak aplikasi insdustri. Kualitas pipa industri dipastikan harus dapat menahan pada tekanan dan suhu yang tinggi, seperti pada riser tube primary reformer. Pada penelitian ini melakukan inspeksi hasil pengelasan pada pipa ASTM A106 grade B dengan inconel 82 menggunakan metalografi dan microhardness. Berdasarkan Hasil visual test dan penetrant test menunjukkan adanya crack pada area pertemuan antara lasan Inconel 82 dengan ASTM A106 grade B. Hasil metallography test pada area pertemuan antara Inconel 82 dengan ASTM A106 grade B terdapat continuous microcrack dan continuous macrocrack. Hasil pengujian microhardness pada daerah sekitar crack memiliki nilai kekerasan lebih rendah dari daerah yang jauh dengan crack. Sambungan pengelasan ASTM A106 grade B dengan Inconel 82 tidak mampu digunakan secara optimal pada temperatur 748oC karena Inconel 82 memiliki unsur silicon sebesar 0.5% yang menyebabkan perbedaan solidifikasi antara ASTM A106 grade B dengan Inconel 82
La Curcumi na Restablece los Niveles de p53 en Células Derivadas de Cáncer Cervicouterino en un Modelo In Vitro e In Vivo
Authors: Rodríguez Donat Vianey Berenice , Patiño Morales Carlos César , Jaime Cruz Ricardo , Villavicencio Guzmán Laura , Salzar García Marcela 
Published: January 2025

La curcumina es un fitoquímico natural con propiedades antineoplásicas, incluida la modulación de p53. Se ha sugerido que apuntar a la actividad de p53 es una estrategia importante en la terapia contra el cáncer. El propósito de este estudio fue describir el efecto de curcumina sobre p53 en líneas celulares derivadas de cáncer cervicouterino y en tumores inducidos in ovo. Se expusieron células HeLa y SiHa a curcumina. Se realizó evaluación de la viabilidad celular por MTT y TUNEL y se cuantificó la expresión de p53 mediante western blot, los resultados indican un efecto importante en la disminución de la viabilidad de las células que recibieron tratamiento y que hay un incremento de los niveles de p53, además aquí demostramos mediante ensayos de pulso y casa que la curcumina aumenta la vida media de p53. En muestras obtenidas de tumores inducidos in ovo también se observó un aumento en los niveles de p53 por inmunohistoquímica. El efecto citotóxico de la curcumina en las células de cáncer de cuello uterino se relacionó también con la activación de la vía Keap1/Nrf2. Nuestros hallazgos sugieren que el uso de curcumina puede reactivar la vía p53 en células cancerosas con p53 de tipo silvestre.
Penerapan Metode Resilient Backpropagation (RPROP) Untuk Prediksi Aktivitas Gempa Bumi Berdasarkan Skala Magnitudo
Authors: Widyaningrum Bajeng Nurul , Kurnia Ramadhani Lingga 
Published: January 2025

Indonesia merupakan salah satu negara dengan tingkat gempa bumi yang cukup tinggi karena memiliki beberapa lempeng utama. Oleh karena itu, prediksi aktivitas gempa bumi menjadi hal yang penting untuk dilakukan guna mengurangi risiko dan kerugian yang ditimbulkan. Telah banyak penelitian terkait dengan prediksi gempa bumi dengan menggunkan beberapa metode. Salah satu metode yang digunakan adalah Metode Backpropagation. Melihat dari penelitian-penelitian sebelumnya, peneliti mengusulkan penerapan Jaringan Saraf Tiruan dengan Algoritma Resilient Backpropagatio untuk prediksi aktivitas gempa bumi berdasarkan nilai magnitudo di Indonesia. Data yang digunakan yaitu data aktivitas gempa bumi bulanan skala magnitudo 4,5 keatas dari periode waktu tahun 1992 hingga 2023 untuk memastikan keberagaman pola aktivitas gempa bumi yang terjadi di berbagai wilayah di Indonesia. Selain parameter skala magnitudo, informasi penting seperti lokasi episenter, dan waktu kejadian juga dimasukkan sebagai fitur input untuk jaringan saraf. Hasil penelitian menunjukkan bahwa prediksi gempa bumi menggunakan metode Jaringan Saraf Tiruan Resilient Backpropagation dengan model arsitektur 6-10-1 dan learning rate 0,6 menunjukkan tingkat akurasi RMSE 0,04778 dan MAE 0,03509. Hasil prediksi menunjukkan pada bulan Februari dengan 67 kejadian dan tertinggi pada bulan Desember dengan 185 kejadian dengan melihat aktifitas gempa bumi di wilayah Indonesia dengan skala magnitudo diatas 4,5. Penelitian ini menunjukkan bahwa model jaringan saraf tiruan dengan algoritma Backpropagation dengan optimasi Resilient mampu memberikan prediksi aktivitas gempa bumi dengan tingkat akurasi yang memuaskan
Navigating Challenges in Neurointervention: Intra-Procedural Diagnosis and Tactical Management of Complications
Authors: Vora Ekta , Dil Jaspreet Singh , Raja A. 
Published: January 2025

Introduction:
Intracranial aneurysms present a significant challenge in neurovascular disorders, often requiring endovascular coiling as a primary treatment option. However, this procedure is marred by complications such as intraprocedural ruptures (IPR), thromboembolic events and arterial dissections, significantly impacting patient outcomes.

Objective:
This study aims to navigate the complexities of neurointerventional procedures and elucidate how intraprocedural diagnosis and management of complications influence long-term patient outcomes.

Methods:
Conducting a retrospective analysis of four cases involving intracranial aneurysm coiling procedures complicated by IPRs, thromboembolic events, flow diverter complications and carotid artery dissections. Each case is meticulously examined to underscore the importance of intraprocedural diagnosis and describe management approaches for these complications.

Results:
Our analysis unveils a spectrum of intraprocedural complications encountered during neurointerventional procedures, emphasising the prevalence and clinical significance of IPRs, thromboembolic events, flow diverter-related issues and arterial dissections. Effective management strategies, including pharmacological interventions, mechanical thrombectomy and adjunctive therapies such as coil embolisation and stent placement, are discussed comprehensively.

Conclusion:
Early detection, precise operator control and prompt intervention are pivotal in mitigating intraprocedural complications associated with intracranial aneurysm coiling. By delineating effective management strategies, this research aims to optimise patient outcomes and minimise procedural risks in neurointerventional practice. Implementing these strategies can lead to enhanced patient care and better overall prognosis for individuals undergoing endovascular treatment for intracranial aneurysms. This study underscores the importance of continuous refinement in neurointerventional techniques to optimise patient safety and treatment efficacy in managing intracranial aneurysms.
Cryotherapy versus fractional carbon dioxide laser in patchy alopecia areata: a self-controlled comparative study
Authors: Afify Ahmed A. , Shaheen Maha A. , Ojaimi Mays Q. 
Published: January 2025

Introduction
Alopecia areata (AA) is an autoimmune noncicatricial alopecia. Many treatments are available but with variable results. Few studies have reported fractional carbon dioxide (FCO2) laser and cryotherapy in treating AA through various mechanisms.

Objective
This study aimed to assess the efficacy and safety of FCO2 laser in comparison to cryotherapy in the treatment of AA.

Patients and methods
This prospective self-controlled comparative study included 22 patients with patchy AA (3 patches). The three patches in each patient were treated by one of the following methods by simple randomization: FCO2 laser, cryotherapy, and the third patch was left without treatment as a control. The sessions were repeated every 2 weeks for six sessions.

Results
Comparison of single-blinded dermatologist assessment of clinical response between the three groups revealed a statistically significantly better response with FCO2 laser and cryotherapy compared with control patches, but there was no statistically significant difference between the FCO2 laser group versus the cryotherapy group (P=1). Comparison between trichoscopic hair parameters before and after treatment showed a significant decrease in black dots, yellow dots, and exclamation mark hair count in both cryotherapy and FCO2 groups. Short vellus hair count showed a significant increase after treatment in the FCO2 group. Exclamation mark hair count before treatment was significantly higher than after treatment in the control group.

Conclusion
Both cryotherapy and FCO2 laser therapy are effective and safe in patchy AA treatment with nearly similar efficacy.
The Effectiveness of Innovative Blended Learning Through Meaning (IBLTM) Model to Improve Students' Science Literacy
Authors: Amijaya Dody Tisna , Raharjo Raharjo , Ibrahim Muslimin , Hawari Asaduddin Al 
Published: January 2025

Objective: This study aims to determine the effectiveness of the Innovative Blended Learning Through Meaning Model (IBLTM) in improving students' scientific literacy at Muhammadiyah 2 High School Sidoarjo. Method: This study used an experimental method with a one-group pretest and posttest design. The subjects of this study were 22 students of class X-1 who participated in learning using the IBLTM Model. Data was collected through a science literacy test instrument in 12 descriptive questions covering six indicators of science literacy. Results: The results of the data analysis showed that the implementation of the IBLTM Model was effective in improving students' scientific literacy. This is indicated by a significant increase in science literacy scores from pretest to posttest, with an average N-Gain of high category. The paired t-test showed a significant difference between the pretest and posttest. In addition, all indicators of science literacy increased, with several indicators reaching the high N-Gain category. Novelty: The IBLTM model applied in this study is an innovative learning approach that integrates the process of meaning in blended learning. This model has been proven to significantly improve scientific literacy, especially in science learning at the secondary school level, and shows that an interactive and meaning-based approach can positively impact students' scientific understanding.
Differentiation of malignant and benign breast lesions with diffusion-weighted imaging: What is the optimum apparent diffusion coefficient value?
Authors: Lerdwatanakiet Chawisa , Prueksadee Jenjeera 
Published: January 2025

Background and objective: To determine the optimum apparent diffusion coefficient (ADC) value in differentiating benign from malignant breast lesions.

Materials and Methods: The study is a retrospective review of the patients who underwent breast magnetic resonance imaging (MRI) at King Chulalongkorn Memorial Hospital between January 2017 and May 2020. ADC values were measured by placement of region of interest (ROI) within the breast lesions using Philips DynaCAD breast analysis system and comparing it with histopathological diagnosis. A receiver-operating-characteristics (ROC) analysis was plotted and the area under the curve (AUC) was evaluated to find the ideal ADC value in the differentiation of benign and malignant breast lesions.

Results: Two hundred and ten lesions in 163 female patients were included in the present study. One hundred twenty-six lesions (60%) were malignant and eighty-four lesions (40%) were benign. The mean ADC values of malignancy (0.913x10-3 mm2/s) were statistically lower than that of benign lesions (1.080x10-3 mm2/s) (mean difference 0.169x10-3 mm2/s, P < 0.001). According to the ROC analysis, the optimum cut-off ADC value of 0.991x10-3 mm2/s was an excellent predictor for differentiated benign and malignant breast lesions (AUC = 0.835, sensitivity 78.6%, specificity 82.5%, accuracy 81%, PPV 85.3% and NPV 75%).

Conclusion: Diffusion-weighted imaging (DWI) was an effective MRI sequence to assess breast cancer by using ADC value as a key parameter in addition to other important imaging findings from MRI. The present study showed the mean ADC value of malignancy was statistically significantly lower than that of benign lesions. The cut-off ADC value of 0.991x10-3 mm2/s had good specificity, accuracy, and PPV to differentiate benign from malignant breast lesions.
Performance of NUA45 bean variety between two generations for seeds grown under farmer management at Rupike Irrigation Scheme in Masvingo, Zimbabwe
Authors: Benhura Chakare , Mapanda Farai , Machisvo Albert , Mavhiri D , Chirambadare Tinashe 
Published: January 2025

Among bean legumes, there are recently developed varieties known as nutritionally enhanced beans such as NUA 35 and NUA 45 sugar beans. The objective of the research was to assess the performance of NUA 45 foundation, certified and commodity seeds grown under farmer management at Rupike Irrigation Scheme in Masvingo. Concentrations of zinc (2.75-4.45mg/kg) and iron (70.85-104.5 mg/kg) in the soils were below expected levels of 100 mg/kg and 150 mg/kg respectively. The NUA 45 sugar bean missed the target potential yield (2400 kg/ha for Highveld) by between 54% and 62%. The 100 seed mass of second generation seeds ranged from 62.13 to 78.47 g. Protein concentration of the seeds which range from 19.79 to 22.86% increased from first generation (F1) to second generation (F2) for each of Foundation, Certified and Commodity seeds. The concentration of fibre with minimum and maximum levels of 5.76% and 8.43 % respectively increased from first generation to second generation for Foundation and Certified seeds. The 95% confidence interval for Zinc concentration at F1 (planted) is 10.84 ≤ µZn≤11.18 mg/kg and also the 95% confidence interval for Zinc concentration at F2 (harvested) is 11.79 ≤ µZn≤12.12 mg/kg and lower than CBI claim of 38.00 mg/Kg. The 95% confidence intervals for iron concentration ranged from 28.50 ≤ µFe≤30.57 mg/kg with the highest being 30.59 ≤ µFe≤32.34 mg/kg are below the CBI claim of 93.00 mg/kg. The nutrients levels increased from the first generation to the second generation of seeds for each of foundation, certified and commodity seeds.
La correcta identificación del daño sanitario como premisa para obtener su reparación: viejos paradigmas, nuevas soluciones
Authors: GALLARDO CASTILLO MARÍA JESÚS 
Published: January 2025

Dos son los requisitos básicos que sustentan toda reclamación
patrimonial y que condicionan una respuesta favorable a su pretensión indemnizatoria:
la existencia misma del daño y su correcta identificación, lo que no siempre
es tarea sencilla puesto que la legislación no ofrece pautas al respecto y la
jurisprudencia lo hace de forma dispar y no siempre con criterios uniformes. Especialmente
compleja resulta esta tarea de identificación del daño en los casos de
omisión del consentimiento informado, en las acciones wrongful, en la doctrina
de pérdida de oportunidad y en el daño desproporcionado. En este trabajo se tratará
de localizar y de dar respuesta y solución a las abundantes dificultades que se
generan en estos casos y con ello facilitar la articulación de las reclamaciones en
esta materia, que con frecuencia ven rechazadas sus pretensiones indemnizatorias
por la complejidad en el entendimiento y aplicación práctica de estas figuras.
Ondarearen arloko erreklamazio guztietan oinarrizko baldintza
bi bete behar dira, kalte-ordaina jasotzeko uzia aldekoa izan dadin: kaltea egotea
eta ondo identifikatzea, baina batzuetan ez da zeregin erraza, legeriak ez duelako
horri buruzko jarraibiderik ematen eta jurisprudentzian modu desberdinetan egin
delako, ez beti irizpide uniformeak erabiliz. Bereziki konplexua izango da kaltea
identifikatzea baimen informaturik ez dagoenean, wrongful egintzetan, aukera galtzeko
doktrinan eta neurriz kanpoko kaltean. Kasu horietan sortzen diren zailtasun
ugariak aurkitu eta horiei erantzuna eta konponbidea eman nahi zaie lan honetan,
gaiari buruzko erreklamazioak errazago antolatu ahal izateko. Izan ere, askotan,
kalte-ordainak jasotzeko uziak baztertu egiten dira zaila delako figura horiek ulertzea
eta praktikan jartzea.
There are two basic requirements that underpin any claim for
damages and that condition a favourable response to the claim for compensation:
the existence of the damage itself and its correct identification, which is not
always a simple task since the legislation does not offer guidelines in this respect
and the case law does so in a disparate manner and not always with uniform
criteria. This task of identifying the damage is particularly complex in cases of
omission of informed consent, in wrongful actions, in the doctrine of loss of
opportunity and in disproportionate damage. This work will attempt to locate and
provide answers and solutions to the many difficulties that arise in these cases
and thus facilitate the articulation of claims in this area, which often see their
claims for compensation rejected due to the complexity in the understanding and
practical application of these figure.
Beyond Immunuhistochemistry: Molecular Insights Into Round Cell Soft Tissue Tumors
Authors: Madoori Prashanth Kumar , Tejavat Sujatha 
Published: January 2025

Abstract
Round cell soft tissue tumors (RCSTTs) are a diverse group of aggressive malignancies that share overlapping clinical, morphological, and immunohistochemical features, posing significant diagnostic challenges. Recent advances in molecular pathology have revolutionized the understanding and classification of these tumors by identifying tumor-specific genetic alterations. This review highlights the role of molecular insights in complementing histopathology and immunohistochemistry to achieve precise diagnosis, risk stratification, and therapeutic decision-making. Key subtypes, including Ewing sarcoma, CIC- and BCOR-rearranged sarcomas, alveolar rhabdomyosarcoma, desmoplastic small round cell tumor, and extraskeletal myxoid chondrosarcoma, are discussed with emphasis on their molecular signatures and clinical significance. The advent of techniques such as fluorescence in situ hybridization (FISH), reverse transcriptase-polymerase chain reaction (RT-PCR), and next-generation sequencing (NGS) has enabled detection of genetic fusions and aberrations critical for tumor identification and targeted therapies. Integration of molecular pathology with traditional diagnostic approaches is essential for improving diagnostic accuracy, prognostication, and therapeutic strategies, paving the way for personalized medicine in the management of RCSTTs. Full form of ABBREVIATIONS are provided at the end.
Drug Utilisation Pattern of Antimicrobial Agents Prescribed for Urinary Tract Infection in Geriatric Patients at a Tertiary Care Hospital: A Retrospective Study
Authors: R S H Velavan , Chaitra S R , R P Nayak 
Published: January 2025

Abstract

Introduction: Drug utilisation studies may lead to several perspectives such as the correct usage of drugs and appropriateness of drug utilisation. Prescription indicators are used to assess the effectiveness of healthcare practitioners in several critical characteristics connected to drug usage. Objectives: 1. To determine the most commonly prescribed antimicrobial agents for treating UTI in Geriatric patients.2. To analyse prescriptions in comparison with WHO prescribing indicators. Methods: All the cases of UTI in geriatric patients with positive urine culture report in the past 6 months (Feb 2023 –July 2023) were included and it was a complete enumeration study. Discrete variables and Categorical variables were represented by percentage. Continuous variables were expressed in mean ± SD. Result: Total of 70 geriatric patients with UTIs were enrolled in the study. Of these male Patients were 31 (44.28%) and female Patients were 39 (55.71%). No of antibiotics per Prescription was 1.97± 1.43. Approximately 40.54% of medications were prescribed using their generic names. About 79.27% of medications were prescribed from the NLEM. 62.16% of drugs were prescribed by injection. systemic hypertension (67.74%) was observed in the majority of UTI patients. Piperacillin + Tazobactam were the most prescribed antibiotics. Duration of hospital stay was 10.22±6.71 days. Conclusion: By addressing these findings, we can enhance the pharmacological management of UTIs in geriatric populations, leading to improved patient outcomes and quality of care.
A Study of Clinical Profile of Patients Presenting with Topical Corticosteroid Induced Facial Dermatoses
Authors: Hosthota Abhineetha , Chandan BC , Chitturi Bhargavi , Nilofer Afreena , Ramesh Ankitha , Bharti Abhishek 
Published: January 2025

Abstract

Introduction: The injudicious use of Topical corticosteroid (TC) over the face has resulted in various complications, encountered day to day. Indian market is flooded with more than 18 different steroid molecules. Methodology: A hospital-based cross-sectional study was conducted on 170 patients at a tertiary care centre. A pre-structured proforma was used to collect socio-demographic details of the subjects with facial dermatoses due to TC misuse for more than 2 weeks. Results: The commonest age group affected was 20-21 years (78.2%) with mostly females (70.6%). Frequent indication for application of TC was melasma (50.0%), Acne (24.1%) and others. Subjects (40.6%) brought a combination of TCs over the counter as a suggestion from friends & relatives. Cutaneous findings of TSDF were exacerbation of pre-existing melasma (41.2%). Conclusion: The results of this study underline the need of strict laws. Futher, awareness creation among patients and primary care physicians should be given prime importance to prevent the epidemic.