bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dialéctica del spleen en Charles Baudelaire
Authors: León Irene 
Published: March 2021

A partir del texto Sobre algunos motivos en Baudelaire de Walter Benjamin y la propia obra del poeta Charles Baudelaire, pretendemos mostrar dos lecturas de sus escritos para exponer tanto el encuentro entre ambas interpretaciones, que tiene lugar en su obra mediante el spleen, como la Vieldeutigkeit de Theodor W. Adorno de estos mismos. Este término, que se ha traducido por “multivocidad”, aparece en la obra Prismas (Adorno, 1962) expresando la posibilidad de múltiples interpretaciones de una realidad.
De esta forma, estudiaremos el dinamismo entre lo que hemos llamado “la hendidura del spleen” y “la huida del spleen”, dos momentos de la obra baudelairiana que consiguen objetivar en sus poemas la realidad histórica que vivió este autor.
Trataremos de descifrar, asimismo, si el spleen que tanto pesó al poeta queda, o puede quedar redimido, mediante su literatura.
From the text On some motifs in Baudelaire by Walter Benjamin and the work of the poet Charles Baudelaire, we intend to show two readings of his writings in order to expose the encounter between both interpretations, which takes place in his work throuth the spleen, and the Vieldeutigkeit of Theodor W. Adorno of these. This term, which has been translated by “multivocity”, appears in the work Prismas (Adorno, 1962) expressing the possibility of multiple interpretations of a reality.
In this way, we will study the dynamism between what we have called “the cleft of the spleen” and “the escape of the spleen”, two moments of Baudelaire’s work that manage to objectify in his poems the historical reality that this autor lived.
We will also try to decipher if the spleen that weighed the poet so much is redeemed, or can be redeemed, through his literature.
La predicción del fracaso empresarial de las cooperativas españolas. Aplicación del Algoritmo Extreme Gradient Boosting
Authors: Romero Martínez Mariano , Carmona Ibáñez Pedro , Pozuelo Campillo Jose 
Published: March 2021

El objetivo del estudio realizado es mostrar la utilidad de la metodología Extreme Gradient Boosting (XGBoost), basada en el aprendizaje automático, en la predicción del fracaso empresarial, particularmente en el ámbito de las empresas cooperativas. Para ello, se ha estimado un modelo a partir de una muestra de cooperativas pertenecientes a diversos sectores, que ha permitido identificar que estas empresas presentan una menor propensión al fracaso cuando alcanzan mayores índices de solvencia y rentabilidad y menor endeudamiento. De acuerdo con los resultados, el modelo estimado XGBoost obtiene una capacidad predictiva del 100% en la muestra de entrenamiento y de un 86% en una muestra de comprobación independiente. Asimismo, se destaca la facilidad de la interpretación de los resultados alcanzados, siendo posible determinar el signo y el efecto de cada variable sobre la predicción final de todas y cada una de las observaciones. Este trabajo aporta a la literatura del fracaso empresarial del sector cooperativo la constatación de la utilidad de una nueva metodología (XGBoost), que proporciona un elevado nivel de aciertos y una sencilla interpretabilidad de los resultados.
El modelo organizativo de la Economía del Bien Común y su comparación con otros enfoques de la sostenibilidad
Authors: Sanchis Palacio Joan Ramon , Campos Climent Vanessa , Ejarque Catalá Ana 
Published: March 2021

Son cada vez más las empresas que están adoptando la sostenibilidad como un enfoque estratégico que garantiza la supervivencia a largo plazo. Más allá de la Responsabilidad Social (RS), se impone un modelo empresarial basado en la triple dimensión económica, social y ambiental, que de acuerdo con el enfoque de la creación de valor compartido de Porter y Kramer, incluya la RS dentro del corazón de la estrategia de la empresa. El modelo de la Economía del Bien Común (EBC), que nace en el centro de Europa en el año 2010 de la mano del profesor de la Universidad de Viena Christian Felber, propone una herramienta, el Balance del Bien Común (BBC), que puede facilitar la implantación de la Sostenibilidad Corporativa en cualquier tipo de organización (pública o privada). El BBC permite medir el impacto social y ambiental de las empresas a través de una serie de variables e indicadores, relacionando cinco valores clave (dignidad humana, solidaridad y justicia social, sostenibilidad ecológica y transparencia y co-participación) con los diferentes stakeholders o grupos de interés. El objetivo de este trabajo consiste en comparar el modelo de la EBC con el enfoque de la Creación de Valor Compartido (CVC) de Porter y Kramer y con la Responsabilidad Social Corporativa, con el objeto de destacar sus principales aportaciones y particularidades.
El valor social generado por los programas de inclusión. El caso del Programa ROMI de la Fundación Secretariado Gitano
Authors: Ruiz-Lozano Mercedes , Ariza-Montes Antonio , Sianes Antonio , Tirado-Valencia Pilar , Fernández-Rodríguez Vicente , López-Martín María del Carmen 
Published: March 2021

La demanda creciente de la sociedad por actuar para conseguir la reducción de las desigualdades ha dado lugar a una diversificación en los modos de ejecución de las políticas sociales, dado el interés de las entidades privadas por contribuir a su consecución. Para avanzar en ello es clave el papel de las entidades no lucrativas, haciéndose patente la necesidad de analizar y comunicar el proceso de creación de valor para legitimar su actuación.Esta investigación presenta la aplicación del SROI, metodología de análisis del impacto social, para analizar, cuantificar y monetizar los cambios generados por la Fundación Secretariado Gitano a través de su programa ROMI, en un sector de la población que se encuentra discriminado en formación y con dificultades de acceso a la empleabilidad: el colectivo gitano de la ciudad de Córdoba.Los resultados del estudio de caso permiten visualizar y cuantificar los impactos que se generan en procesos de creación de valor de este tipo, proporcionando una información que facilita supervisar la implementación de la estrategia de la organización, así como conocer si se está respondiendo a las necesidades de los stakeholders. De igual modo, la metodología puede servir de referente para otras organizaciones que promuevan actividades similares.
Molecular Surveillance and Burden of Plasmodium falciparum Isolate to the Resistance of Artemisinin and Mefloquine-based Therapy among Febrile Subjects in Ilorin Metropolis, North-Central Nigeria
Authors: Nassar Adebayo Sulaiman , Bakarey Adeleye Solomon , Abubakar Abdulazeez Aderemi , Oluwagbemiga Michael Adeleke , Alabi Shukurat Yetunde , Hamzat Monsurat Bidemi , Olawuyi Clement Oladayo 
Published: March 2021

Introduction: Artemisinin-based combination treatments (ACTs) such as Artemisinin and mefloquine are generally accepted as the best forms of therapy for uncomplicated falciparum malaria and usually exceed more than 90% effectiveness. However, the problem of resistance to the target parasites remains a great challenge especially within the northcentral Nigeria. Therefore this study aimed to assess the burden of resistance of Plasmodium falciparum to artemisinin and Mefloquine from the blood smear febrile patients attending tertiary health facility in Ilorin, Nigeria.
Methodology: The study was carried among two hundred and one (201) consented febrile individuals age ranged 1-46 years (Mean=22.7 years; M=39; F=61) between May and August 2019. Blood samples collected were subjected to Microscopy using Giemsa staining technique and Rapid diagnostic test (RDT) using (SD BIOLINE Malaria Ag P.f/Pv, South Korea) kit to detect the presence of P. falciparum A semi-structured questionnaire was used to capture demographic and other relevant information while data was analysed with SPSS version 21.
Results: Of the 201 samples tested, 113 (56.5%) were positive for Microscopy and RDT. Fifty of the positive samples for Microscopy and RDT were further subjected to PCR technique for the presence of Plasmodium falciparum and amplification of Kelch13 and FR1gene mutation of which one (2.0%) showed amplification for the PfKelch13 gene mutation for artemisinin while none was recorded for FR1 gene mutation in case of Mefloquine.
Conclusion: This study reported a high rate of detection for Plasmodium falciparum using microscopy and RDT but moderately low rate of resistance to amplification for the PfKelch13 gene mutation for artemisinin but none for FR1 gene mutation for mefloquine by PCR. This suggests a clue for further monitoring of the artemisinin and Mefloquine resistance by detection of some molecular markers in k13 and FRI genes of Plasmodium in our communities in Nigeria.
Relationship of Non Alcoholic Fatty Liver Disease (NAFLD) and Serum Level of Thyroid Stimulating Hormone (TSH) in Normal Reference Range
Authors: Khalil Doaa Ameen , Raouf Yasser Mohammed Abdul , Al-Bendary Amal Said , Okasha Kamal Mohamed 
Published: March 2021

Background: Non-alcoholic fatty liver disease (NAFLD) can increase the incidence of cardiovascular disease and hepatocellular carcinoma. Thyroid hormones also play important roles in hepatic lipid metabolism and hepatic insulin resistance. Hypothyroidism is associated with reduced lipolysis and decreased liver uptake of free fatty acids derived from triglycerides. In recent years, the correlation between overt or subclinical hypothyroidism and NAFLD has been discussed. The relationship between NAFLD and thyroid function parameters remains unclear.
Aim: We aimed to evaluate the relationship between serum level of Thyroid Stimulating Hormone (TSH) within normal reference range and Non Alcoholic fatty liver Disease (NAFLD).
Subjects and Methods: This is a cross sectional case control study on 40 patients with NAFLD and a control group of 20 healthy individuals, who were attendants of Outpatient Clinic of Internal Medicine Department of Tanta University Hospitals and EL-Menshawy General Hospital from February 2018 to the end of January 2019.
Results: In the present study, univariate regression analysis showed that serum levels of AST, FT3, FT4 and Anti-TPO were independent risk factors of NAFLD, while in multivariate analysis the only independent risk factor of NAFLD was Anti-TPO serum level.
Conclusion: Serum levels of AST, FT3, FT4 and Anti-TPO were independent risk factors of NAFLD in univariate regression analysis, while in multivariate analysis the only independent risk factor of NAFLD was Anti-TPO serum level. Despite the positive correlation between serum TSH level and grade of NAFLD, the study didn’t show serum TSH level as independent risk factor of NAFLD.
Concept Design of a Portable Carrot Seeder
Authors: Valentin Marvin T. , Smeets Alex , Ciolkosz Daniel E. , Jasinskas Algirdas , Onalan Milagros B. , Dulay Alvin C. , Dumalhin Leonardo D. , Sudaypan Sr. Constantino T. , Anongos Jr. Stanley F. , Launio Cheryll C. , Galad Marlon N. , Suclad Roger Lee M. , Pagnas Keithler M. 
Published: March 2021

A concept design of a carrot seeder, filed for patent application, was successfully developed in this study. Farmers were visited and interviewed and the data regarding their existing practices in planting carrots, corresponding tools and equipment and planting requirements such as hill spacing, row spacing and plant bed size were gathered. These data were used as input in the preparation and simulation of the seeder design with the aid of Solidworks software.
The seeder consisted of seed metering assembly, frame, ground wheels, skid, handle, power transmission, furrow opener and seed covering mechanism. It has 5 metering discs and the spacing between rows is adjustable. The metering disc is provided with grooves on its periphery of size that can accommodate 2 to 5 carrot seeds. Draft force to push the device in usage is 10 kg-force. The designed overall weight is 12 kg.
Strain-level Identification of Beneficial Lactobacilli of Dairy Origin using 16S rRNA Sequencing: A Biotechnology Approach
Authors: Aforijiku S. , Fakorede C. O. , Adediran A. B. 
Published: March 2021

Aim: This study investigated the cultural method and 16S rRNA gene analysis to reveal the composition and diversity of lactic acid bacteria (LAB) from dairy origin (spontaneous fermented cow milk) in Nigeria.
Methods: Six dairy samples which includes two raw cow milk, two raw goat milk and two fermented cow milk (nono) were collected and subjected to standard microbiological investigation using both cultural and molecular methods. The dairy samples were cultured on MRS media, and the isolates were identified using physiological and biochemical parameters. DNA of four selected probiotic LAB isolates from nono were amplified using PCR while the amplicons were electrophoresed in agarose gel, pre-stained with ethidium bromide and characterized by 16S rRNA gene analysis. The result of the DNA sequencing were analyzed using NCBI BLAST.
Results: A total of 55 presumptive LAB were isolated. Twenty nine (29) Lactobacillus plantarum representing 52.7%, Pediococcus acidilactici 15(27.2%), Lactobacillus casei and Lactobacillus brevis 4(7.3%) while Lactobacillus fermentum 3(5.5%) were recorded respectively. Result of the gel electrophoresis revealed DNA size of approximately 1500bp. The selected probiotic LAB from nono used in this study were confirmed as Lactobacillus plantarum N17, Lactobacillus plantarum N24, Lactobacillus brevis N10 and Lactobacillus casei N1 based on 16S rRNA gene sequence analysis while the phylogenetic analysis revealed a 98-100% similarity with a high homology level which affirms the strain of the organism.
Conclusion: This study has demonstrated the diversity of LAB existing in dairy samples known as fermented cow milk (nono) which could be harnessed as valuable sources for LAB isolation and potential probiotic organisms.
The transmembrane protein LRIG1 triggers melanocytic tumor development following chemically induced skin carcinogenesis
Authors: Hoesl Christine , Fröhlich Thomas , Posch Christian , Kneitz Hermann , Goebeler Matthias , Schneider Marlon R. , Dahlhoff Maik 
Published: March 2021

The incidence of melanoma and nonmelanoma skin cancer has increased tremendously in recent years. Although novel treatment options have significantly improved patient outcomes, the prognosis for most patients with an advanced disease remains dismal. It is, thus, imperative to understand the molecular mechanisms involved in skin carcinogenesis in order to develop new targeted treatment strategies. Receptor tyrosine kinases (RTK) like the ERBB receptor family, including EGFR/ERBB1, ERBB2/NEU, ERBB3, and ERBB4, are important regulators of skin homeostasis and their dysregulation often results in cancer, which makes them attractive therapeutic targets. Members of the leucine‐rich repeats and immunoglobulin‐like domains protein family (LRIG1‐3) are ERBB regulators and thus potential therapeutic targets to manipulate ERBB receptors. Here, we analyzed the function of LRIG1 during chemically induced skin carcinogenesis in transgenic mice expressing LRIG1 in the skin under the control of the keratin 5 promoter (LRIG1‐TG mice). We observed a significant induction of melanocytic tumor formation in LRIG1‐TG mice and no difference in papilloma incidence between LRIG1‐TG and control mice. Our findings also revealed that LRIG1 affects ERBB signaling via decreased phosphorylation of EGFR and increased activation of the oncoprotein ERBB2 during skin carcinogenesis. The epidermal proliferation rate was significantly decreased during epidermal tumorigenesis under LRIG1 overexpression, and the apoptosis marker cleaved caspase 3 was significantly activated in the epidermis of transgenic LRIG1 mice. Additionally, we detected LRIG1 expression in human cutaneous squamous cell carcinoma and melanoma samples. Therefore, we depleted LRIG1 in human melanoma cells (A375) by CRISPR/Cas9 technology and found that this caused EGFR and ERBB3 downregulation in A375 LRIG1 knockout cells 6 h following stimulation with EGF. In conclusion, our study demonstrated that LRIG1‐TG mice develop melanocytic skin tumors during chemical skin carcinogenesis and a deletion of LRIG1 in human melanoma cells reduces EGFR and ERBB3 expression after EGF stimulation.
Porous Strontium Chloride Scaffolded by Graphene Networks as Ammonia Carriers
Authors: Cao Zhejian , Akhtar Farid 
Published: March 2021

AbstractStrontium chloride (SrCl2) as ammonia (NH3) carriers has been widely exploited due to its high ammonia uptake capacity and low energy penalty for ammonia release. However, the dramatic volume swing during absorption–desorption cycles, from SrCl2 to Sr(NH3)8Cl2 to SrCl2, imposes a challenge to structure SrCl2 for ammonia storage applications. Herein, a novel porous SrCl2 structure with SrCl2 loading up to 96 wt%, scaffolded by reduced graphene oxide (rGO) networks is reported. The optimized porous SrCl2‐rGO composite with 80 wt% SrCl2 loading maintains the macro‐ and micro‐structure accommodating the volume swing during ammonia absorption–desorption cycles without disintegration, whereas structured SrCl2 pellets disintegrates directly after the first cycle of NH3 absorption. The structured porous 80 wt% SrCl2‐rGO composite demonstrates rapid absorption–desorption kinetics, 140% faster in absorption and 540% faster in desorption compared with pure SrCl2 pellet. The enhancement of the surface area and the presence of SrCl2 particles in the pores of rGO networks result in a robust and stable structure offering rapid ammonia absorption–desorption kinetics while countermining the volume swing by self‐adjusting “breathing.”
All‐Solid‐State Ion Synaptic Transistor for Wafer‐Scale Integration with Electrolyte of a Nanoscale Thickness
Authors: Yu Ji‐Man , Lee Chungryeol , Kim Da‐Jin , Park Hongkeun , Han Joon‐Kyu , Hur Jae , Kim Jin‐Ki , Kim Myung‐Su , Seo Myungsoo , Im Sung Gap , Choi Yang‐Kyu 
Published: March 2021

AbstractNeuromorphic hardware computing is a promising alternative to von Neumann computing by virtue of its parallel computation and low power consumption. To implement neuromorphic hardware based on deep neural network (DNN), a number of synaptic devices should be interconnected with neuron devices. For ideal hardware DNN, not only scalability and low power consumption, but also a linear and symmetric conductance change with a large number of conductance levels is required. Here, an all‐solid‐state polymer electrolyte‐gated synaptic transistor (pEGST) is fabricated on an entire silicon wafer with CMOS microfabrication and initiated chemical vapor deposition process. The pEGST shows good linearity as well as symmetry in potentiation and depression, conductance levels up to 8,192, and low switching energy smaller than 20 fJ pulse−1. Selected 128 levels from 8,192 are used to identify handwritten digits in the MNIST database with the aid of a multilayer perceptron, resulting in a recognition rate of 91.7%.
4D Printing of Multi‐Stimuli Responsive Protein‐Based Hydrogels for Autonomous Shape Transformations
Authors: Narupai Benjaporn , Smith Patrick T. , Nelson Alshakim 
Published: March 2021

AbstractStimuli responsive hydrogels that can change shape in response to applied external stimuli are appealing for soft robotics, biomedical devices, drug delivery, and actuators. However, existing 3D printed shape morphing materials are non‐biodegradable, which limits their use in biomedical applications. Here, 3D printed protein‐based hydrogels are developed and applied for programmable structural changes under the action of temperature, pH, or an enzyme. Key to the success of this strategy is the use of methacrylated bovine serum albumin (MA–BSA) as a biodegradable building block to Pickering emulsion gels in the presence of N‐isopropylacrylamide or 2‐dimethylaminoethyl methacrylate. These shear‐thinning gels are ideal for direct ink write (DIW) 3D printing of multi‐layered stimuli‐responsive hydrogels. While poly(N‐isopropylacrylamide) and poly(dimethylaminoethyl methacrylate) introduce temperature and pH‐responsive properties into the printed objects, a unique feature of this strategy is an enzyme‐triggered shape transformation based on the degradation of the bovine serum albumin network. To highlight this technique, protein‐based hydrogels that reversibly change shape based on environmental temperature and pH are fabricated, and irreversibly altered by enzymatic degradation, which demonstrates the complexity that can be introduced into 4D printed systems.
Fungal Cell Wall‐Graphene Oxide Microcomposite Membrane for Organic Solvent Nanofiltration
Authors: Zhang Liyuan , Zhang Mengchen , Liu Gongping , Jin Wanqin , Li Xiaoyan 
Published: March 2021

AbstractHigh permeability and selectivity have long been pursued in membrane separation technology. However, this purpose remains a paramount challenge for molecular separations mainly limited by the trade‐off between permeance and ‐selectivity. Here, a bio‐utilization strategy based on deep understanding of bio‐features to fabricate a cell wall‐graphene oxide microcomposite membrane for organic solvent nanofiltration is rationally designed. The membrane displays a unique configuration with alternating stacking of cell wall layers and ultrathin graphene oxide layers. Moreover, the interactions between the cell wall and graphene oxide as well as between the membrane and solvent are mainly revealed by all atom molecular dynamics to uncover the possible working principle of the membrane. Specifically, the strong graphene oxide‐cell wall interaction and anti‐swelling behavior of the cell wall together restrict the expansion of the graphene oxide layer to promise high selectivity. Meanwhile, the well‐developed porosity of the cell wall allows a high throughput of various solvents through the membrane, showing excellent rejection for small molecules and solvent permeance as high as 56 L m2 h1 bar−1. The proposed cell wall microcomposite 2D structure could encourage the practical applications of GO‐based membranes.
Solutal‐Marangoni‐Flow‐Mediated Growth of Patterned Highly Crystalline Organic Semiconductor Thin Film Via Gap‐Controlled Bar Coating
Authors: Lee Seon Baek , Lee Siyoung , Kim Dae Gun , Kim Seung Hyun , Kang Boseok , Cho Kilwon 
Published: March 2021

AbstractApplication‐oriented patterned growth of organic semiconductor (OSC) thin films with single crystalline domains is crucial for fabricating sophisticated high‐performance organic‐electronic and optoelectronic devices; however, fabricating these patterned nanometer‐thick crystals in a simple, fast, and effective manner is a difficult task with a roll‐to‐roll printing process. Here, a simple bar‐coating approach to form an array of single‐crystal‐like OSC thin‐film patterns at a rate of a few millimeters per second is introduced. To this end, the processing parameters of a gap‐controlled bar‐coating method is optimized, including coating speed, crystal nucleation, and solution fluidics, which allow a high degree of morphological control of bar‐coated OSC films in an area of several centimeters. In particular, it is demonstrated that the solutal‐Marangoni flow induced by a suitable solvent additive can considerably improve molecular mass transport and induce favorable vertical phase separation. Thus, organic transistors based on the OSC patterns fabricated with the additive‐assisted bar coating show a field‐effect mobility of up to 20 cm2 V−1 s−1 and superior operational stability. The proposed bar coating method will facilitate an industry‐level application of organic electronics.