bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myocardial Work and long-term prognosis in patients after ST-segment elevation acute myocardial infarction
Authors: Timoteo A , Moura Branco L , Galrinho A , Mano T , Rio P , Castelo A , Cruz Ferreira R 
Published: October 2021

Abstract

Background
Left ventricular (LV) global longitudinal strain has demonstrated incremental prognostic value over LV ejection fraction (LVEF) in patients with ST-segment-elevation acute myocardial infarction. However, LV global longitudinal strain (GLS) does not take into consideration the effect of afterload. Myocardial work (MW) by speckle-tracking echocardiography integrates blood pressure measurements (afterload) with LV GLS and it has been recently demonstrated that Global Work Efficiency (GWE) is associated with long-term all-cause mortality. It remains to be demonstrated if MW indices are associated with hard cardiovascular endpoints. The present study aimed to investigate the prognostic value of global LV MW obtained from pressure-strain loops with echocardiography in patients with ST-segment-elevation myocardial infarction.

Methods
A total of 100 consecutive ST-segment-elevation myocardial infarction patients (mean age, 61±12 years; 75% men) that survived to discharge were retrospectively analysed. LVEF, GLS and all LVMW indices were measured by transthoracic echocardiography before discharge (4.6±2.0 days after admission). All patients had at least a two-year follow-up (mean follow-up of 833±172 days). Outcomes: all-cause mortality, major acute cardiovascular events (a composite of cardiovascular mortality, myocardial infarction, stroke, unplanned cardiovascular admission) and heart failure hospitalization.

Results
In the two-year follow-up, 6 patients died, there were 17 patients with MACE, and 3 patients were hospitalized with heart failure. We confirmed that for all-cause mortality, GWE showed higher discrimination, compared to GLS (Table 1), with a cut-off of 83% (log-rank &lt;0,001). For MACE, the performance of all methods is suboptimal, with an AUC &lt;0.65 for all variables, except for GLS. For heart failure admission, performance is slightly better, but GLS is still the better parameter to predict this event.

Conclusions
LVGWE is a better predictor of all-cause mortality compared to GLS, but MW indices failed to demonstrate a prognostic impact in long-term cardiovascular events. Prospective studies are warranted to confirm this finding.

Funding Acknowledgement
Type of funding sources: None. Table 1
Left ventricular diastolic function during pregnancy: insights from conventional and speckle tracking echo parameters
Authors: Tryfou E , Kostakou P , Kostopoulos V , Paraskevaidis I , Olympios C , Kouris N 
Published: October 2021

Abstract

Introduction
Profound changes occur in the cardiovascular system during pregnancy, regarding to induce cardiac pumping function. Although LV systolic and diastolic function have been thoroughly studied using conventional indices, speckle tracking parameters of cardiac function are not well described.

Purpose
The aim of our study was to evaluate the LV diastolic function during an uncomplicated pregnancy using both traditional and newer speckle tracking parameters.

Methods
We prospectively enrolled 40 consecutive pregnant women in whom serial echocardiographic evaluation was performed in each pregnancy trimester (1st: 8th–12th week, 2nd: 22th–26th week, 3rd: 32–36th week) and 6 months after delivery. Mitral inflow velocities (E, A), mitral annulus TDI velocities (E', A'), ratio E/A and E/E' and untwisting velocity rate were measured after cautious selection of studies with legible images in.

Results
The peak E transmitral inflow velocity during early diastole decreased significantly during pregnancy especially between 2nd and 3rd trimester and increased again postpartum (p1-2=0.475, p2-3&lt;0.05 p3-4&lt;0.05). The peak A flow velocity during atrial contraction did not change significantly during pregnancy (p1-2=0.333, p2-3=0.952, p3-4=0.989). As a result, E/A ratio was decreasing as pregnancy was advancing (p1-2=0.964, p2-3&lt;0.05, p3-4=0.240). TDI E' early diastolic velocity was decreased especially in the 3rd trimester and recovered postpartum (p1-2=0.138, p2-3&lt;0.01, p3-4&lt;0.01) while E/E' ratio was increased especially in the 2nd trimester (p1-2&lt;0.05, p2-3=0.572, p3-4=0.021, p1-4=0.383) and also recovered postpartum. Peak untwisting velocity rate demontrated a progressive decrease during pregnancy, although not statistically significant. There was a trend towards recovery in the puerperium (p1-2=0.072, p2-3=0.679, p3-4=0.052, p1-4=0.929) (Table 1).

Conclusion
Our study demonstrated that diastolic function seems to be impaired during an uncomplicated pregnancy. However all the conventional and newer speckle tracking indices of diastolic function remain in normal range. Postpartum appears to be a recovery process in all parameters.

Funding Acknowledgement
Type of funding sources: None.
Ventricular-arterial coupling changes as an early predictor of left ventricular remodelling in atrial fibrillation
Authors: Gaczol M , Olszanecka A , Rajzer M , Wojciechowska W 
Published: October 2021

Abstract

Objective
Atrial fibrillation (AF) can be associated with adverse atrial and ventricular remodelling also in the absence of persistently elevated heart rate. Ventricular–arterial coupling (VAC) plays a pivotal role in cardiac and aortic adaptation to pathophysiological conditions. The aim of this study was to investigate changes in conventional and novel VAC indexes in long lasting paroxysmal AF.

Methods
Participants with paroxysmal AF, in sinus rhythm on admission, with preserved left ventricle (LV) systolic function and carotid – femoral pulse wave velocity (PWV) within normal range were carefully selected from consecutive patients admitted to University Hospital in Krakow for scheduled AF ablation. We excluded those with established coronary artery disease, moderate or severe heart valves disease, with uncontrolled hypertension or other comorbidities. The anthropometric and demographic data, medical history, and habits were collected using standardized questionnaire. A total of 51 (mean age 57.7 yrs; 37 men) patients underwent simultaneous echocardiographic and arterial data acquisition. End-systolic pressure was determined from central pulse wave analyses. Arterial elastance (Ea) and LV elastance (Ees) were calculated as end-systolic pressure/stroke volume and end-systolic pressure/end-systolic volume. Two-dimensional speckle tracking was used to derive LV global longitudinal strain (GLS), and then PWV to GLS ratio was calculated.

Results
Patient presented moderate (EHRA class median = 2b) and long-lasting symptoms (median of AF history 3 years). There was an association of Ees (parameter estimate (PE) 0.12; P=0.0004) and VAC (Ea/Ees) (PE=−0.13; P=0.33) with duration of AF history in the univariate linear regression model and this association retain statistically significant in a model including age, sex, history of hypertension and hypercholesterolemia. Longer history of AF was related to lower PWV to GLS ratio, however this association reached statistical significance only among patients with AF lasting more than 3 years (PE=−0.14; P=0.024) and persisted significant after accounting for covariates.

Conclusion
The relationship between AF and LV dysfunction is complex and potentially bi-directional. Paroxysmal AF however, can contribute to abnormality in heart–vessel coupling, even when LV function remained within the normal range, indicating early stage of ventricular remodelling due to arrythmia.

Funding Acknowledgement
Type of funding sources: Public Institution(s). Main funding source(s): Collegium Medicum, Jagiellonian University, Krakow
Effect of interventional edge-to-edge repair in tricuspid regurgitation on ring dimensions
Authors: Goebel B , Salomon C , Abdulrahman M , Richter S , El Garhy M , Costello-Boerrigter L , Lapp H , Lauten P 
Published: October 2021

Abstract

Background
The concept of percutaneous tricuspid valve edge-to-edge repair (pTVR) is based on the connection of leaflets in the area of insufficiency using a coaptation device. By closing the coaptation device a considerable tractive force is applied on the leaflets, which might have an effect on the valve ring. Aim of the study was to examine the impact of device implantation on tricuspid ring dimensions.

Methods
During pTVR 3D zoom loops of tricuspid valve were acquired before and after clip placement using transoesophageal echocardiography. Measurements of TV ring dimensions included the following parameters: ring area (TV area), maximal diameter, minimal diameter, eccentricity index (Figure 1). Tenting area was derived from a four-chamber view of the valve. In addition, regurgitation severity was graded from 1+ to 5+ by measuring vena contracta area (VCA3D) in 3D full volume colour Doppler loop using multiplanar reconstruction. Right atrial (RA) and ventricular volumes (RVVd3D, RVVs3D) and function (RVEF3D) were assessed in a 3D full volume loop.

Results
The study population comprised 97 patients (age 78±6 years, 47 male), who underwent pTVR at our hospital. As expected cavity dimension correlated with TV area size (for RVVd3D r=0.51, p&lt;0.001 and for RA volume r=0.71, p&lt;0.001). The mean TV ring area was significantly reduced (ring area 8.53±2.23 cm2/m2BSA vs. 7.55±2.18 cm2/m2BSA, p&lt;0.001) and the ring shape became more oval (Eccentricity index 1.2±0.15 vs. 1.29±0.17, p&lt;0.001) after pTVR. The reduction of ring area (12±7%, range 0.7–28%) showed an only modest correlation to the number of implanted coaptation devices (r=0.30, p&lt;0.001) and percentage reduction of VCA3D (r=0.36, p&lt;0.001). In the patient group with a ring area change ≥12% a reduction to TR grade ≤2+ by pTVR was achieved in 83% of cases, whereas only 62% of patients reached moderate TR when area change was below 12%.

Conclusion
pTVR using coaptation devices reduces the ring area. This effect is related to the number of devices implanted.

Funding Acknowledgement
Type of funding sources: None.
Impact of chronic mitral regurgitation on 3D atrial size and mechanics. Insights from the prospective 3D-PRIME study
Authors: Cramariuc D , Valeur A , Persson R M , Berg-Hansen C E , Urheim S 
Published: October 2021

Abstract

Background
Chronic mitral regurgitation (MR) leads to progressive left atrial (LA) dilation. Its relative contribution to 3-dimensional (3D) LA structural and functional remodelling and the impact of concomitant clinical and hemodynamic factors, has been less explored.

Aims
To assess 3D LA size and mechanics, as well as mean LA pressure estimated from the pulmonary vein flow, in relation to chronic MR severity.

Methods
In the prospective 3D-PRIME (3D Echocardiography and Cardiovascular Prognosis in Mitral Regurgitation) study, 46 patients with chronic MR (69±13 years, body mass index (BMI) 26.2±4.3kg/m2, 50% women, 26% with atrial fibrillation, 30% with severe MR) recruited at one heart valve center were investigated with 2D and 3D transthoracic and transesophageal echocardiography. MR severity was quantified by the regurgitant volume (RV) and MR classified as organic, atrial functional or ventricular functional, as by current recommendations. LA size was measured by 3D maximum volume (LAV) indexed for body surface area (LAVI), LA mechanics by 3D peak relative increase in longitudinal volume in the reservoir phase (Sr), and mitral size by 3D annulus area and total leaflet area. Pulmonary vein Doppler flow profile was recorded in both right and left upper veins, and mean LA pressure was estimated from the average pulmonary vein systolic/diastolic velocity time integral ratio.

Results
Average mitral RV was 38±26ml, LAVI 53ml/m2, and Sr 17±11%. Increased mitral RV correlated with higher LAV and mean LA pressure (Figure 1), larger mitral annulus area (r=0.42) and total leaflet area (r=0.38) (all p&lt;0.01), but not with Sr. In backward stepwise multivariate linear regression analyses, increased LAVI was independently predicted by larger mitral RV, higher age and atrial fibrillation (R2=0.62), higher mean LAP by larger mitral RV, body mass index and atrial fibrillation (R2=0.55), while lower Sr was associated with higher age and atrial fibrillation (R2=0.62) (all p&lt;0.001). Patients with atrial functional MR (30% of the total group) had the largest LAVs and lowest Sr despite slightly lower mitral RV (Figure 2).

Conclusion
Chronic MR is associated with progressive increase in LA volume, mean LA pressure, and mitral annulus and total leaflet area. While MR is accompanied by low 3D LA longitudinal deformation, impaired LA mechanics is multifactorial and related closely to age and history of atrial arrythmias.

Funding Acknowledgement
Type of funding sources: Public hospital(s). Main funding source(s): Haukeland University Hospital Figure 1Figure 2
Decreased left atrial function in morbid obese patients without known cardiac disease
Authors: Aga Y , Kroon D , Snelder S , Van Dalen B , Zijlstra F 
Published: October 2021

Abstract

Background
Obesity is an important risk factor for atrial fibrillation and heart failure. However, little is known about the underlying pathophysiology. Left atrial (LA) dysfunction due to diastolic dysfunction and chronic volume overload may play a significant role in morbid obesity.

Purpose
To compare LA function in morbid obese and non-obese individuals, and secondly, to determine whether LA function in morbid obese patients improves one year after bariatric surgery.

Methods
Data of morbid obese patients without known cardiac disease included in the CARdiac Dysfunction In Obesity (CARDIOBESE) study were used. Patients and age- and gender matched non-obese controls underwent transthoracic echocardiography. In the morbid obese patients echocardiography was repeated 1 year after bariatric surgery. LA reservoir strain (LASr), LA conduit strain (LAScd), and LA contractile strain (LASct) were analyzed with speckle tracking using dedicated software (TomTecArena, integrated in Sectra IDS7).

Results
64 morbid obese patients were compared with 46 non-obese controls. Obese patients had significantly decreased LA function compared with non-obese individuals (LASr 39.6±10.8% vs 31.3±8.3%, p&lt;0.001; LAScd −24.9±8.3% vs −19.5±7.2%, p&lt;0.001; LASct −14.7±5.3% vs −11.8±3.5%, p=0.002). There was no significant difference in diastolic function between the non-obese and morbid obese group (normal function 38.2% vs 52.7%, intermediate function 3.6% vs 4.5%, dysfunction 0% vs 0.9%, p=0.689). In 47 obese patients LA strain did not improve significantly 1 year after bariatric surgery, although there was a trend of improvement in all phases of LA function (LASr 31.0±8.2% vs 33.1±8.2%, p=0.089; LAScd −19.4±7.1% vs −20.4±6.6%, p=0.349; LASct −11.6±3.3% vs −12.8±5.4%, p=0.151).

Conclusions
Morbid obese patients without known cardiac disease have impairment in all phases of LA function. This subclinical cardiac dysfunction would have remained largely unmasked with assessment of diastolic function according to current guidelines, as shown by the comparable proportion of obese and non-obese individuals with diastolic dysfunction. LA dysfunction in obesity may therefore be an early sign of cardiac disease and a predictor for developing atrial fibrillation and heart failure. LA function did not improve one year after bariatric surgery. Longer follow-up after bariatric surgery may be needed to investigate whether improvement of LA function will occur after a longer period following weight loss surgery.

Funding Acknowledgement
Type of funding sources: Public hospital(s). Main funding source(s): BeterKeten Outcomes of the study populationLeft atrial strain outcomes
Clinical outcome after MitraClip procedure: role of right ventricle
Authors: Barosi A , Gherbesi E , Colombo S , Giavarini A , Cusmano I , Colombo A , Di Biasi M , Viecca M 
Published: October 2021

Abstract

Background
MitraClip system is a device for percutaneous edge-to-edge repair of the mitral valve in symptomatic patients with severe mitral regurgitation (MR) not eligible for surgery, but frequently heart failure symptoms remain substantial on mid-term follow-up. Recently, right ventricular (RV) to pulmonary arterial (PA) coupling has emerged as a relevant prognostic predictor in heart failure but little is known about its prognostic role in patients after MitraClip implantation.

Purpose
To identify echocardiographic predictors of clinical outcome after MitraClip procedure, with a particular focus on RV-PA coupling.

Methods
We retrospectively analyzed the data of patients with severe MR who underwent MitraClip implantation between April 2015 and October 2019 at our Institution. Echocardiographic data were assessed at baseline, 3 and 12 months after the procedure; RV to PA coupling was assessed using the ratio between tricuspid annular plane systolic excursion (TAPSE) and pulmonary artery systolic pressure (PASP). Functional class was assessed at 12 months of follow-up. Significance level was set to 0.05 and SPSS was used for statistical analysis.

Results
41 patients were included (age 77.1±7.3, 71% male, BMI 25.8±5.5). MR was primary, functional and mixed in 22, 76 and 2% of patients, respectively. 1/2/3 mitraclips were implanted in 39/56/5% of patients, respectively.
Echocardiographic data at baseline, at 3 and 12 months follow-up are shown in Table.
NYHA class at 12 months significantly correlated with TAPSE and PASP at 3 months follow-up echocardiogram (beta coefficient −0.83 and 0.78 respectively). On the contrary, NYHA class did not show a correlation with left ventricular ejection fraction (LVEF) or residual MR grade.
At 12 months 44% of patients showed an improvement in NYHA class; these patients had a better TAPSE (22.7±1.3 vs 19.4±4.6 mm), a lower PASP (37.9±10.2 vs 48.5±12.9 mmHg) and a better TAPSE/PASP (0.61±0.2 vs 0.42±0.2) compared to patients who did not improve their functional class, while LVEF and residual MR did not differ.

Conclusion
In this sample of significant MR undergoing repair with MitraClip System, patients with functional class improvement at 12 months follow-up showed a better RV-coupling without difference in LV function and residual MR.

Funding Acknowledgement
Type of funding sources: None. Table 1
Cardio-pulmonary transit-time by cardiac magnetic resonance imaging: associates to infarct severity and adverse events after reperfused STEMI
Authors: Troger F , Reindl M , Pamminger M , Tiller C , Holzknecht M , Lechner I , Reinstadler S J , Metzler B , Klug G , Mayr A 
Published: October 2021

Abstract

Background
Cardiac magnetic resonance (CMR) data on cardiopulmonary-transit-time (cpTT) and its associates with infarct characteristics and clinical outcome after reperfused ST-elevation myocardial infarction (STEMI) are lacking so far.

Purpose
cpTT may serve as surrogate parameter for integrative cardiac performance and has been linked to heart failure.

Methods
A total of 207 patients (179 men [87%], median age 55 [interquartile range (IQR) 49–64] with acute STEMI underwent CMR on day 3 [IQR 2–4] and 4 months (m) [IQR 4–5] after primary percutaneous coronary intervention. cpTT was taken as the time between the peaks of time-intensity curves of gadolinium contrast to pass from the right ventricle (RV) to the left ventricle (LV). Infarct size, extent of microvascular obstruction (MVO), RV and LV dimensions and function were assessed at both occasions.

Results
cpTT decreased significantly between baseline and 4m CMR scan (8.6 seconds [IQR 7.5–9.6] to 7.8 sec [IQR 7–8.7], respectively, p&lt;0.0001). Patients with presence of MVO had significantly prolonged cpTT at baseline and 4m follow-up (all p&lt;0.022). According to Cox regression analysis (“functional model”) baseline cpTT (hazard ratio (HR) 1.5, 95% confidence interval (CI) 1.1–2.2; p=0.008) remained significantly associated to the occurrence of major adverse cardiac events (MACE) after adjustment for LV ejection fraction (EF) and cardiac index. According to Cox regression analysis (“tissue model”) baseline cpTT (HR 1.462, 95% CI 1.02–2.09, p=0.039) as well as extent of MVO (HR 1.196, 95% CI 1.081–1.324, p=0.001) remained significantly associated to MACE after adjustment for infarct size. Baseline cpTT (area under the curve [AUC]: 0.725, 95% confidence interval [CI] 0.57–0.88; p&lt;0.009) was significantly higher for the prediction of MACE compared to LV ejection fraction (AUC: 0.686, 95% CI 0.51–0.87; p=0.031. AUC difference: 0.039, p&lt;0.03). In Kaplan-Meier analysis, cpTT ≥9 sec was associated with clinical adverse cardiovascular events (p=0.008).

Conclusion
Following reperfused STEMI, cpTT predicts prognosis independently of infarct size and systolic function. Moreover, cpTT provides significantly higher prognostic implication in comparison with LV ejection fraction.

Funding Acknowledgement
Type of funding sources: None. cpTT over the cardiac cycle.Computation of cpTT in 2 STEMI patients.
Echocardiographic parameters as predictors of three-months mortality in patients with 2019 Coronavirus infection
Authors: Miranda Aquino T , Pereira-Forcado J M , Ordonez-Salazar B , Dominguez-Trejo G , Rangel-Guerra A , Martinez-Castillo J , Vazquez-Orozco R J , Guevara-Canseco A P , Perez-Topete S E , Aceves-Millan R , Amezcua-Gomez L , Ixcamparij-Rosales C 
Published: October 2021

Abstract

Background
Coronavirus disease 2019 is a systemic entity, where cardiac involvement has been described. The echocardiogram is a diagnostic tool that describes myocardial damage with good certainty.

Objectives
Determine which echocardiographic parameters are predictors of mortality. Analyze if there is a difference in clinical, laboratory and echocardiographic variables in terms of patients who died versus those who survived. Investigate the cut-off point of the echocardiographic parameters that is best associated with mortality.

Methods
Prospective, analytical, comparative study. Patients admitted to the hospital with Coronavirus 2019 infection. Clinical, laboratory and echocardiographic variables will be assessed. The association with three-month mortality of the different variables will be determined. We used ROC-curves for the best cut-off associated with mortality. The association with three-month mortality was analized using Cox regression, unadjusted analysis of the variables was performed, as well as adjusted analysis for age and gender.

Results
84 patients were included, a mortality of 29% was documented. Significant differences were found in the left atrial volumen index, the E/e', the proportion of dilatation of the right ventricle and diastolic dysfunction. Tricuspid annulus anterior systolic excursion (TAPSE), pulmonary artery acceleration time (PAA), tricuspid regurgitation velocity (TRV), pulmonary artery systolic pressure (PASP), left ventricular longitudinal strain (LVGLS), of the left atrium (LAGLS) and the right ventricular free wall longitudinal strain (RVFWLS). Right ventricular dilation, right ventricular shortening fraction, TAPSE, PASP, TRV, LVGLS, LAGLS, and RVFWLS were associated with mortality.

Conclusion
Right ventricular dilation, right ventricular shortening fraction, TAPSE, PASP, TRV, LVGLS, LAGLS, and RVFWLS are the echocardiographic parameters that were associated with three-month mortality.

Funding Acknowledgement
Type of funding sources: None. Table 2