bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Rentabilitas Ekonomi Perusahaan Property And Real Estate Di BEI 2016-2018
Authors: Chikmawati Yuni , Yuniningsih Yuniningsih 
Published: March 2021

Penelitian ini bertujuan untuk mengetahui apakah terdapat pengaruh antara perputaran kas, perputaran modal kerja dan perputaran total aset terhadap rentabilitas ekonomi pada perusahaan property and real estate yang terdaftar di Bursa Efek Indonesia.
Sampel dipilih melalui metode purposive sampling sebanyak 46 perusahaan property and real estate yang terdaftar di Bursa Efek Indonesia periode 2016-2018. Penelitian ini menggunakan data sekunder yaitu dari laporan keuangan perusahaan. Metode analisis yang digunakan yaitu uji asumsi klasik, analisis linier berganda dan uji hipotesis.
Hasil dari penelitian ini adalah secara parsial, perputaran kas berpengaruh negatif tidak signifikan terhadap rentabilitas ekonomi. Untuk perputaran modal kerja mempunyai pengaruh positif tidak signifikan terhadap rentabilitas ekonomi. Dan untuk perputaran total aset mempunyai pengaruh yang positif signifikan terhadap rentabilitas ekonomi. Sedangkan secara simultan perputaran kas, perputaran modal kerja, dan perputaran total aset berpengaruh terhadap rentabilitas ekonomi.
The Truth of Cultural Diplomacy
Authors: Baskoro Riski Muhamad 
Published: March 2021

<p><em>Since the United States Information Agency (USIA) is no longer active to operate cultural diplomacy in the post-cold war, the concept of cultural diplomacy has experienced a time of crisis in the context of International Relations studies. For a decade, cultural diplomacy was marginalized and considered obsolete until finally in the early 2000s, cultural diplomacy was revived and activated both in practice and theory. Since then, cultural diplomacy has returned to its path. The discourse of cultural diplomacy in International Relations studies has developed to gain more specific activities. This is a qualitative research, with the aim of understanding cultural diplomacy in a more holistic way. The results of this study indicate a debate and a lack of consensus on several aspects of cultural diplomacy and bringing much unclear explanation. This study also shows a dichotomy between cultural diplomacy and other approaches.</em></p>
КОМУНІКАТИВНА СКЛАДОВА ОРГАНІЗАЦІЇ ТА ЗДІЙСНЕННЯ АНТИКРИЗОВОГО УПРАВЛІННЯ
Authors: Вовк Н. , Мохнар Л. 
Published: March 2021

У статті розглядається комунікативна складова організації та здійснення антикризового управління. Розглядаючи процес антикризового управління як концепт, авторами обґрунтовано у ньому визначну роль комунікації. Аргументуючи складність даного процесу, його багатовекторність та багатоаспектність, авторами на основі аналізу застосування підходів, теорій та моделей комунікації визначено її специфіку, задачі, особливості, та виокреслено ряд умов щодо підвищення ефективності її організації та здійснення у процесі антикризового управління.
Ключові слова: комунікація; соціальна комунікація; комунікація в умовах кризи; кризова ситуація; надзвичайна ситуація; антикризове управління.
КOУЧ-ТEXНOЛOГIЇ ЯК ЗACIБ ФOРМУВAННЯ EМOЦIЙНOЇ КOМПEТEНТНOCТI МAЙБУТНIX ПCИXOЛOГIВ
Authors: Гичко Ю. 
Published: March 2021

У cтaттi зaзнaчaєтьcя, щo cтвoрeння кoучинг-ceрeдoвищa в ocвiтнiй oргaнiзaцiї дoзвoляє прaцювaти iз мaйбутнiми пcиxoлoгaми в фoрмaтi прaктикo-oрiєнтoвaнoгo пiдxoду, aпeлюючи дo влacнoгo дocвiду, cтвoрювaти нoвi, бiльш eфeктивнi мoдeлi пeдaгoгiчнoї взaємoдiї чeрeз викoриcтaння твoрчoгo пoтeнцiaлу. Цe дaє мoжливicть мaйбутнiм пcиxoлoгaм виxoдити нa бiльш виcoкий прoфeciйний рiвeнь, який вiдпoвiдaє cучacним ocвiтнiм cтaндaртaм i зaбeзпeчує виcoкий рiвeнь cфoрмoвaнocтi eмoцiйнoї кoмпeтeнтнocтi.
Ключoвi cлoвa: кoучинг-ceрeдoвищe; мaйбутнi пcиxoлoги; eмoцiйнa кoмпeтeнтнicть; прoфeciйний рiвeнь; твoрчий пoтeнцiaл.
Neo-Gothic Church Designs by Antal Hofhauser
Authors: Németh Nóra , Marótzy Katalin 
Published: March 2021

Antal Hofhauser was a descendant of an old stonemason family in Buda. Sacral architecture played an important role in lifework. There is good reason to suppose that his work and position as a teacher played a very important role, increased his authority and the appearance of his entries was far more beautiful than that of other entries. Teaching certain subjects for long decades enabled him to vary the already existing solutions easily. His authority and his good reputation from previous principals may have helped him on several occasions, that he was able to win assignments from the second rank, or a supervisor position. Based on his studies in Vienna and his interest in urban architecture, he always adapted his churches to the current situation and possibilities. Not too inventively, but fulfilling the principals requirements, he varied and vested the fundamental towered, longitudinal, Latin-cross-shaped, which had one or three naves, a polygon-closed sanctuary and was canonised from the Middle Ages, with well-known elements chosen from medieval styles. This layout, and similar constructions, like fundations can also be observed in the case of Bátaszék and Békéscsaba. Based on the cover he used in general, his style could be called "Backsteingotik" (Brick Gothic), however, the forms he used and the building materials he replaces evoke the architecture of French territories instead.
Blended Learning with Jigsaw in Increasing Interest, Motivation, and Learning Outcomes in Sports Sociology Learning
Authors: Nopiyanto Yahya Eko , Sutisyana Ari , Raibowo Septian , Yarmani Yarmani 
Published: March 2021

The purpose of this study was to increase the interest, motivation, and learning outcomes of students in learning sports sociology by applying blended learning with the jigsaw method. The research method used was an action classroom with two cycles. The research subjects were students of the fifth semester with a total of 39 students. The results showed that in the pre-cycle students' interest in learning was in the low category, learning motivation was in the sufficient category. The results of cycle 1 showed that interest in learning student increases in the high category with a percentage of 70%, learning motivation was in the high category with a percentage of 75%, learning outcomes were in the high category with a percentage of 70%. The results of cycle 2 showed that student interest in learning increases in the high category with a percentage of 80%, learning motivation was in the high category with a percentage of 85%, learning outcomes were in the category high with a percentage of 85%. So it can be concluded that the application of blended learning with the jigsaw method can increase the interest, motivation, and learning outcomes in learning sports sociology.
Patient-Specific Sedation Management via Deep Reinforcement Learning
Authors: Eghbali Niloufar , Alhanai Tuka , Ghassemi Mohammad M. 
Published: March 2021

Introduction: Developing reliable medication dosing guidelines is challenging because individual dose–response relationships are mitigated by both static (e. g., demographic) and dynamic factors (e.g., kidney function). In recent years, several data-driven medication dosing models have been proposed for sedatives, but these approaches have been limited in their ability to assess interindividual differences and compute individualized doses.Objective: The primary objective of this study is to develop an individualized framework for sedative–hypnotics dosing.Method: Using publicly available data (1,757 patients) from the MIMIC IV intensive care unit database, we developed a sedation management agent using deep reinforcement learning. More specifically, we modeled the sedative dosing problem as a Markov Decision Process and developed an RL agent based on a deep deterministic policy gradient approach with a prioritized experience replay buffer to find the optimal policy. We assessed our method's ability to jointly learn an optimal personalized policy for propofol and fentanyl, which are among commonly prescribed sedative–hypnotics for intensive care unit sedation. We compared our model's medication performance against the recorded behavior of clinicians on unseen data.Results: Experimental results demonstrate that our proposed model would assist clinicians in making the right decision based on patients' evolving clinical phenotype. The RL agent was 8% better at managing sedation and 26% better at managing mean arterial compared to the clinicians' policy; a two-sample t-test validated that these performance improvements were statistically significant (p &lt; 0.05).Conclusion: The results validate that our model had better performance in maintaining control variables within their target range, thereby jointly maintaining patients' health conditions and managing their sedation.
Serum Uric Acid Level Is Positively Associated With Higher Bone Mineral Density at Multiple Skeletal Sites Among Healthy Qataris
Authors: Ibrahim Wisam Nabeel , Younes Nadin , Shi Zumin , Abu-Madi Marawan Abdelhamid 
Published: March 2021

BackgroundOxidative stress has been implicated as a fundamental mechanism in the decline of bone mass. Although serum uric acid (SUA) has potent antioxidant properties, the findings of many epidemiological and experimental studies couldn’t draw a clear conclusion on the relation between SUA and bone health. We aim to investigate the association between SUA and bone mineral density (BMD) at different skeletal sites among healthy Qataris.MethodologyA cross-sectional analysis including total-body and site-specific bone mineral density scores and other serological markers of 2981 healthy Qatari adults (36.4 ± 11.1 years) from the Qatar biobank database was conducted. The study participants were divided into quartiles based on the level of SUA, and the BMD was measured using dual-energy X-ray absorptiometry (DXA). Multiple regression analyses were applied to investigate the association between SUA and BMD adjusting for multiple confounding factors.ResultsHigh levels of SUA were significantly associated with the increased bone mineral density of the total body and at site-specific skeletal locations after adjusting for age and gender (p-value &lt; 0.001). Further adjustment for body mass index (BMI), smoking, vitamin D, alkaline phosphatase, and estimated glomerular filtration rate (eGFR) levels attenuated the association but the association remained significant for individuals with high SUA levels (p-value ≤ 0.01).The association between SUA and BMD was not significant in non-obese, females, young adults, and smokers. However, no interaction was found between SUA and age, gender, BMI and smoking.ConclusionHigher SUA levels are associated with a high bone density among healthy Qatari adults. However, such observation demands further investigations to outline the underlying mechanisms.
The Relationship Between Thyroid Function and Metabolic Syndrome and Its Components: A Cross-Sectional Study in a Chinese Population
Authors: He Jiaji , Lai Yaxin , Yang Jing , Yao Yongli , Li Yongze , Teng Weiping , Shan Zhongyan 
Published: March 2021

ObjectiveThe present study examined the relationship between thyroid function status and the prevalence of metabolic syndrome in a Chinese population.MethodsCross-sectional data were obtained from the Thyroid Disease, Iodine Nutrition and Diabetes Epidemiology (TIDE) Survey. A total of 62,408 subjects aged ≥18 years were enrolled. Differences in metabolic indicators and the prevalence of metabolic syndrome according to sex and thyroid function status were compared. Logistic regression was used to analyze the influence of thyroid function on metabolic syndrome and its components.ResultsThe prevalence of metabolic syndrome was generally higher in men than women. Overt hyperthyroidism and subclinical hypothyroidism had a significant effect on metabolism in men. Body mass index (BMI), waist circumference, and triglycerides (TGs) were significantly lower in men in the overt hyperthyroidism group, and BMI, waist circumference, systolic blood pressure (SBP) and TGs were higher in men in the subclinical hypothyroidism group than men in the normal group. Overt and subclinical hypothyroidism had significant impacts on metabolic components in women. BMI, waist circumference, TGs, SBP and DBP in the subclinical and overt hypothyroidism groups were significantly higher than the euthyroid group in women. The relative risk of abdominal obesity and hypertriglyceridemia was increased in women with hypothyroidism. Thyroid dysfunction had different effects on metabolic syndrome and its components before and after menopause.ConclusionThyroid function had important effects on the prevalence of metabolic syndrome. Women with hypothyroidism, especially post-menopausal women, had a higher risk of metabolic syndrome than men.
iDNA-MT: Identification DNA Modification Sites in Multiple Species by Using Multi-Task Learning Based a Neural Network Tool
Authors: Yang Xiao , Ye Xiucai , Li Xuehong , Wei Lesong 
Published: March 2021

MotivationDNA N4-methylcytosine (4mC) and N6-methyladenine (6mA) are two important DNA modifications and play crucial roles in a variety of biological processes. Accurate identification of the modifications is essential to better understand their biological functions and mechanisms. However, existing methods to identify 4mA or 6mC sites are all single tasks, which demonstrates that they can identify only a certain modification in one species. Therefore, it is desirable to develop a novel computational method to identify the modification sites in multiple species simultaneously.ResultsIn this study, we proposed a computational method, called iDNA-MT, to identify 4mC sites and 6mA sites in multiple species, respectively. The proposed iDNA-MT mainly employed multi-task learning coupled with the bidirectional gated recurrent units (BGRU) to capture the sharing information among different species directly from DNA primary sequences. Experimental comparative results on two benchmark datasets, containing different species respectively, show that either for identifying 4mA or for 6mC site in multiple species, the proposed iDNA-MT outperforms other state-of-the-art single-task methods. The promising results have demonstrated that iDNA-MT has great potential to be a powerful and practically useful tool to accurately identify DNA modifications.
Protocol for LASER: A Randomized Evaluation and an Associated Registry of Early Anticoagulation With Edoxaban After Ischemic Stroke in Patients With Atrial Fibrillation
Authors: Alrohimi Anas , Jickling Glen , Jeerakathil Thomas , Shuaib Ashfaq , Khan Khurshid , Kate Mahesh , Hill Michael D. , Buck Brian , Butcher Ken 
Published: March 2021

Background: The optimal timing of anticoagulation after stroke in patients with atrial fibrillation (AF) is unknown.Aim and Hypothesis: Our primary aim is to demonstrate the safety of edoxaban initiation within 5 days of AF related stroke. Our secondary aim is to determine predictors of hemorrhagic transformation (HT) after AF related stroke. We hypothesize that the rate of radiological HT will not be increased in patients starting edoxaban within 5 days of AF related stroke, relative to those in whom initiation is delayed. We hypothesize that the risk of HT in patients treated with edoxaban can be predicted using RNA expressed in leukocytes at time of stroke.Methods and Design: LASER (Lixiana Acute Stroke Evaluation Registry) is a randomized controlled trial with an associated registry (clinicaltrials.gov NCT03494530). One hundred and fifty patients with ischemic stroke and AF will undergo baseline Computed Tomography (CT) scan and will be randomized 2:1 within 5 days of symptom onset to early (≤5 days, n = 100) or delayed (6–14 days, n = 50) edoxaban initiation. Participants will undergo clinical assessment and repeat CT at 7 days and clinical assessment at 90 days.Study Outcomes: The primary outcome is the rate of incident radiological HT. Secondary outcomes include symptomatic HT, recurrent ischemic stroke, recurrent sub-clinical infarcts on follow up CT, systemic hemorrhagic complication rate, National Institute of Health Stroke Scale and modified Rankin Scale at day 7 and 90, mortality within 90 days, quality of life assessments at day 90, and predictors of HT, including RNA expression by 6 pre-selected candidate genes.Discussion: Event rates for both HT and recurrent ischemic events, in patients treated with early vs. delayed edoxaban initiation are unknown. The primary study endpoint of LASER is an objective performance criterion relevant to clinical decision making in patients with AF related stroke. This study will provide data required for a definitive safety/efficacy study sample size power calculation.
Light-To-Moderate Raw Garlic Consumption Frequency Is Inversely Associated With Thickened Carotid Intima-Media Thickness: A Population-Based Study
Authors: Liu Yunyun , Meng Ge , Zhang Qing , Liu Li , Wu Hongmei , Gu Yeqing , Zhang Shunming , Zhang Tingjing , Wang Xuena , Sun Shaomei , Zhou Ming , Jia Qiyu , Song Kun , Tan Fengling , Niu Kaijun 
Published: March 2021

Background: Previous animal and clinical studies have reported beneficial effects of garlic preparations on carotid intima-media thickness (cIMT). However, no epidemiological study has yet investigated the association between dietary raw garlic consumption and cIMT in the general population. The objective of this study was investigating the association between dietary raw garlic consumption and thickened cIMT in Chinese adults.Methods: This cross-sectional study used data from the Tianjin Chronic Low-grade Systemic Inflammation and Health Cohort Study. A total of 4,329 general adults from 2015 to 2017 were included in this study. Frequency of consumption of raw garlic was summarized as four categories for analysis: &lt; 1 time/week, 1 time/week, 2-3 times/week, ≥4 times/week with a validated food frequency questionnaire. The thickened cIMT was defined as common carotid artery IMT ≥ 1.0 mm or a carotid bifurcation IMT ≥ 1.2 mm by ultrasonography. Multivariable logistic regression analysis was used to examine the association between frequency of raw garlic consumption and thickened cIMT.Results: The prevalence of thickened cIMT is 22.9% among these participants. The adjusted odds ratios (95% confidence intervals) associated with the different frequencies were 1.00 (reference) for &lt; 1 time/week, 0.74 (0.59, 0.94) for 1 time/week, 0.71 (0.55, 0.92) for 2–3 times/week, and 0.94 (0.71, 1.25) for ≥ 4 times/week.Conclusions: Light-to-moderate raw garlic consumption was inversely associated with thickened cIMT, whereas greater raw garlic consumption (i.e., ≥4 times/week) was not associated with thickened cIMT. Future longitudinal studies should be conducted to test these findings.
Efficacy of First Line Systemic Chemotherapy and Multikinase Inhibitors in Advanced Hepatocellular Carcinoma: A Systematic Review and Network Meta-Analysis
Authors: Oranratnachai Songporn , Rattanasiri Sasivimol , Pooprasert Anantaporn , Tansawet Amarit , Reungwetwattana Thanyanan , Attia John , Thakkinstian Ammarin 
Published: March 2021

BackgroundHepatocellular carcinoma (HCC) is the third most fatal cancer, with a 5-year survival rate of 18%. Standard frontline-therapy is multikinase inhibitors (MKIs), but accessibility is still limited, particularly in developing countries. This network meta-analysis (NMA) aimed to compare the efficacy of usual chemotherapy vs MKIs.MethodRandomised-controlled trials (RCTs) comparing any among chemotherapy vs MKIs in treatment-naïve patients with advanced HCCs were identified from MEDLINE and SCOPUS databases. Overall survival (OS) and progression-free survival (PFS) probabilities and times were extracted from Kaplan-Meier curves using Digitizer, and then converted to individual patient time-to-event data. A one-stage mixed-effect survival model was applied to estimate median OS and PFS. A two-stage NMA was applied for the overall response rate and adverse events (AEs) outcome.ResultsA total of 20 RCTs were eligible for NMA. Lenvatinib was the best treatment among single MKIs, with median OS and PFS of 9 and 6.3 months, without significant differences in AEs relative to other MKIs. Median OS and PFS were 0.70 (-0.42, 1.83) and 2.17 (1.41, 2.93) months longer with Lenvatinib than Sorafenib. Among chemotherapy agents, FOLFOX4 had the longest median OS and PFS at 7.9 and 4.3 months, respectively, without significant AEs compared to other chemotherapies. The combination of Sorafenib+Doxorubicin prolonged median OS and PFS to 12.7 and 6.3 months, respectively.ConclusionUse of the MKIs Lenvatinib or Sorafenib as first line systemic treatment for advanced HCC could be beneficial. However, FOLFOX4 might be the optimal choice in a developing country where the health-care budget is limited.
Clinical Characteristics According to Age and Duration of Symptoms to Be Considered for Rapid Diagnosis of Pediatric Intussusception
Authors: Park In Kyu , Cho Min Jeng 
Published: March 2021

Purpose:The purpose of this study was to evaluate whether clinical findings in children with ileocolic intussusception differ based on age and duration of symptoms and to assess the clinical characteristics of diagnosed and undiagnosed patients to determine which symptoms make diagnosis more difficult.Methods:We reviewed 536 medical records of &lt;15-year-old children diagnosed with ileocolic intussusception between 2008 and 2019. We divided the children into three categories according to age (&lt;1 year, 1–2 years, and ≥2 years). The children were also divided into two groups based on whether symptoms lasted for more or &lt;6 h. Diagnosed and undiagnosed children were assessed separately during for the initial evaluation.Results:Following analysis of the three age groups, bloody stool, post-enema bloody stool, diarrhea, vomiting, poor oral intake, and lethargy were more frequent in children aged &lt;1 year. In children aged ≥2 years, non-specific abdominal pain was more frequent and the undiagnosed rate was higher. Following analysis of the duration of symptoms, paroxysmal pain was significantly more frequent in the early group (&lt;6 h), and bloody stool and fever were significantly more frequent in the late group (≥6 h). Nonspecific abdominal pain was more frequent and the door-to-diagnosis time was significantly longer in the undiagnosed group than in the diagnosed group.Conclusions:Clinical findings of ileocolic intussusception vary depending on the age and duration of symptoms. Younger children with paroxysmal pain, vomiting, bloody stool, poor oral intake, or lethargy should be suspected of having intussusception. In older children, non-specific abdominal pain without bloody stool may be a symptom of intussusception. Glycerin enema is helpful in diagnosing intussusception in children with no typical symptoms.