bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indices of ACTH‐stimulated adrenal venous sampling as predictors of postsurgical outcomes in primary aldosteronism
Authors: Lee Seung Hun , Kim Jong Woo , Yoon Hyun‐Ki , Kim Sang Wan , Kim Su Jin , Lee Kyu Eun , Lee Yu‐Mi , Sung Tae‐Yon , Hong Suck Joon , Shin Chan Soo , Koh Jung‐Min , Kim Jung Hee 
Published: October 2021

AbstractObjectiveThis study aimed to investigate the impact of indices of adrenal venous sampling (AVS) on postsurgical outcomes in patients with primary aldosteronism (PA).Design and PatientsThis retrospective study determined biochemical and clinical outcomes based on ACTH‐stimulated AVS parameters (lateralisation index [LI], contralateral ratio [CLR], and ipsilateral ratio [ILR]) in 251 patients with PA at 3 months after surgery.ResultsModified complete biochemical success was achieved in 8 of 12 (66.7%) patients with LI = 3–4, 39 of 47 (83.0%) with LI = 4–10, and 155 of 169 (91.7%) with LI ≥ 10 (p = .004 for trend). Modified complete biochemical success was achieved in 29 of 38 (76.3%) patients with CLR ≥ 1 and ILR ≤ 2, 73 of 86 (84.9%) with CLR = 0.25–1 and ILR > 2, and 100 of 104 (96.2%) with CLR < 0.25 and ILR > 2 (p = .001 for trend). After adjusting for confounders, modified complete biochemical success was associated with an LI ≥ 10 (odds ratio [OR] = 6.32; 95% confidence interval [CI] = 1.33–29.93) using LI = 3–4 as a reference and combined CLR < 0.25 and ILR > 2 (OR = 11.49; 95% confidence interval [CI] = 2.49–53.01) using combined CLR ≥ 1 and ILR ≤ 2 as a reference. Using combined CLR ≥ 1 and ILR ≤ 2 as a reference, complete clinical success was associated with combined CLR < 0.25 and ILR > 2 (OR = 3.10; 95% CI = 1.03–9.28) and combined CLR = 0.25–1 and ILR > 2 (OR = 4.92; 95% CI = 1.64–14.76).ConclusionLI ≥ 10 may be appropriate for achieving biochemical success. With ILR > 2, CLR < 0.25, and CLR < 1 may be appropriate for achieving biochemical and clinical success, respectively.
Guillain–Barré syndrome after coronavirus disease 2019 vaccine: A temporal association
Authors: da Silva Gustavo Figueiredo , da Silva Caroline Figueiredo , Oliveira Raddib Eduardo Noleto da Nobrega , Romancini Fabiana , Mendes Rafael Marques , Locks Amanda , Longo Maria Francisca Moro , Moro Carla Heloisa Cabral , Longo Alexandre Luiz , Braatz Vera Lucia 
Published: October 2021

AbstractBackgroundGuillain–Barré syndrome (GBS) is an acute monophasic immune‐mediated polyradiculoneuropathy, preceded by gastrointestinal or respiratory infections in up to two‐thirds of patients. On rare occasions, people develop GBS after vaccination, but no causal association has been proven. In the current coronavirus disease 2019 (COVID‐19) pandemic, some cases have been reported associating COVID‐19 vaccine with GBS.Case presentationWe report a case of a 62‐year‐old woman with GBS after the first dose of the Oxford/AstraZeneca vaccine against SARS‐CoV‐2. The symptoms started 3 weeks after the vaccine, and were characterized by ascending and progressive paresthesia in the upper and lower limbs, followed by loss of strength of the upper limbs and dysphagia for solids. The hypothesis of GBS was confirmed by clinical presentation compatible with albuminocytologic dissociation in cerebrospinal fluid and based on the Brighton criteria level 2. The treatment was a 5‐day course of intravenous immunoglobulin with an improvement of symptoms.ConclusionsIn the absence of other causes, the diagnosis of GBS was made, with evidence of a clear temporal association with COVID‐19 vaccine. However, a cautious position is important when assigning a particular side‐effect directly to a vaccine. It is important to emphasize that it is a temporal association only and the benefits of COVID‐19 vaccination continue to outweigh the possible consequences.
Surgical approach combining implantoplasty and reconstructive therapy with locally delivered antibiotic in the treatment of peri‐implantitis: A prospective clinical case series
Authors: González Regueiro Iria , Martínez Rodriguez Natalia , Barona Dorado Cristina , Sanz‐Sánchez Ignacio , Montero Eduardo , Ata‐Ali Javier , Duarte Fernando , Martínez‐González José María 
Published: October 2021

AbstractBackgroundNonsurgical treatment, resective surgery, reconstructive surgery, or combined approaches have been proposed for the treatment of peri‐implantitis, with variable results.PurposeTo evaluate the 1‐year clinical and radiographic outcomes following combined resective and reconstructive surgical treatment with topical piperacillin/tazobactam antibiotic in the management of peri‐implantitis.Material and MethodsForty‐three patients diagnosed with peri‐implantitis were included. Surgical treatment consisted of implantoplasty of the supra‐crestal component of the defect, the application of a topical antibiotic solution over the implant surface, and subsequent reconstruction of the intra‐osseous component of the peri‐implant defect. The primary outcome was disease resolution, defined as the absence of bleeding on probing (BoP) and/or suppuration on probing (SoP), a peri‐implant pocket probing depth (PPD) ≤5 mm, and no bone loss >0.5 mm 1 year after surgery. Secondary outcomes included changes in BoP, PPD, SoP, and peri‐implant marginal bone levels. One implant per patient was included in the analysis.ResultsThe treatment success rate of the 43 dental implants included in the study was 86% at 1 year after surgery. Mean PPD and BoP decreased from 6.41 ± 2.11 mm and 100% at baseline to 3.19 ± 0.99 mm (p < 0.001) and 14% (p < 0.001) at 1 year, respectively. SoP was significantly reduced from 48.8% at baseline to 0% 1 year after surgery (p < 0.001). Radiographically, a mean defect fill of 2.64 ± 1.59 mm was recorded (p < 0.001).ConclusionsThe combination of a resective and reconstructive surgical approach together with locally delivered antibiotic achieved a high disease resolution rate after 1 year of follow‐up and constitutes a viable option for the management of peri‐implantitis.
Efficacy of keratinized mucosal augmentation with a collagen matrix concomitant to the surgical treatment of peri‐implantitis: A dual‐center randomized clinical trial
Authors: Solonko Myroslav , Regidor Erik , Ortiz‐Vigón Alberto , Montero Eduardo , Vilchez Blanca , Sanz Mariano 
Published: October 2021

AbstractAimThe aim of this study was to evaluate the efficacy of a xenogeneic collagen matrix to augment the width of keratinized mucosa (KM), concomitantly to the surgical treatment of peri‐implantitis, when compared to the use of an autologous soft tissue graft.Material and methodsIn this 12‐month parallel‐arm randomized controlled clinical trial, patients with peri‐implantitis were randomly assigned, one month after non‐surgical therapy, to surgical resective treatment of peri‐implantitis consisting on an apically positioned flap (APF) in combination with a KM augmentation procedure, either with an autologous free gingival graft (FGG) or a collagen matrix (CM). Primary outcomes were the increase in the width of KM and probing pocket depth (PPD) reduction at 12 months. As secondary outcomes, peri‐implant radiographic and patient‐reported outcomes were assessed.ResultsThe intention‐to‐treat population consisted of 49 subjects, assigned to either the APF + FGG (n = 23) or APF + CM (n = 26) group. PPDs were reduced by 1.6 mm (SD 1.0) and 1.7 mm (SD 1.2), respectively, being these differences non statistically significant (p = .782). However, the increase in KM was significantly higher in the APF + FGG compared with APF + CM (2.5 mm [SD 1.6] vs. 1.6 mm [SD 1.2], respectively (p = .033).ConclusionThe tested surgical modalities resulted in similar improvements of the clinical parameters. Both free gingival graft and collagen matrix significantly increased the peri‐implant keratinized mucosa, but this KM gain was significantly higher with the free gingival graft. Use of CM, however, was better appreciated by the patients, in terms of pain perception and analgesic consumption, although the surgical time was similar.
Neglected Factors Bearing on Reaction Time in Language Production
Authors: Scheer Tobias , Mathy Fabien 
Published: October 2021

AbstractThe input to phonological reasoning are alternations, that is, variations in the pronunciation of related words, such as in electri[k] ‐ electri[s]‐ity. But phonologists cannot agree what counts as a relevant alternation: the issue is highly contentious despite a research record of over 50 years. We believe that the experimental setup presented may contribute to this debate based on a kind of evidence that was not brought to bear to date. Our experiment was thus designed to distinguish between alternations where phonological computation plays no role, and those where it has contributed to language production. The design manipulates two factors that to date have not been considered in experimental studies of language production: linguistic complexity and alternation specificity. The former is understood as extra processing demands issued by two types of linguistic activity, morphosyntactic and phonological. Our results show that reaction time latencies are longer when participants are burdened with both morphosyntactic and phonological tasks than when they carry out just a morphosyntactic task, and they are still shorter in absence of both types of demands. These results allowed us to address alternation specificity, that is, the fact that different alternations (within a language or across languages) may be driven by different production routines (an idea that is consensual among linguists but underdeveloped in the psycholinguistic literature). Our study shows that four different alternations in French produce alternation‐specific signatures in reaction time latencies. These findings may thus redound to the advantage of psycholinguistic studies by identifying two new factors, as well as produce results that speak to the linguistic quarrels.
Bone marrow macrophage‐derived exosomal miR‐143‐5p contributes to insulin resistance in hepatocytes by repressing MKP5
Authors: Li Linfang , Zuo Huiyan , Huang Xiuqing , Shen Tao , Tang Weiqing , Zhang Xiaoyi , An Tong , Dou Lin , Li Jian 
Published: October 2021

AbstractObjectiveIn this study, we aim to explore the role of bone marrow macrophage‐derived exosomes in hepatic insulin resistance, investigate the substance in exosomes that regulates hepatic insulin signalling pathways, reveal the specific molecular mechanisms involved in hepatic insulin resistance and further explore the role of exosomes in type 2 diabetes.Materials and methodsHigh‐fat diet (HFD)‐fed mice were used as obesity‐induced hepatic insulin resistance model, exosomes were isolated from BMMs which were extracted from HFD‐fed mice by ultracentrifugation. Exosomes were analysed the spectral changes of microRNA expression using a microRNA array. The activation of the insulin signalling pathway and the level of glycogenesis were examined in hepatocytes after transfected with miR‐143‐5p mimics. Luciferase assay and western blot were used to assess the target of miR‐143‐5p.ResultsBMMs from HFD‐fed mice were polarized towards M1, and miR‐143‐5p was significantly upregulated in exosomes of BMMs from HFD‐fed mice. Overexpression of miR‐143‐5p in Hep1‐6 cells led to decreased phosphorylation of AKT and GSK and glycogen synthesis. Dual‐luciferase reporter assay and western blot demonstrated that mitogen‐activated protein kinase phosphatase‐5 (Mkp5, also known as Dusp10) was the target gene of miR‐143‐5p. Moreover, the overexpression of MKP5 could rescue the insulin resistance induced by transfection miR‐143‐5p mimics in Hep1‐6.ConclusionBone marrow macrophage‐derived exosomal miR‐143‐5p induces insulin resistance in hepatocytes through repressing MKP5.
Retrospective and current trend of wild‐cat trade in Peru
Authors: Mena José Luis , Vento Rosa , Martínez Jorge Luis , Gallegos Ana 
Published: October 2021

AbstractSeveral species of wild cats are threatened with extinction due to habitat loss, persecution or retaliatory killing by humans as a result of real or perceived livestock depredation, and illegal trade. The trade of individuals or their parts has been a recurring threat over the years, especially prior to the establishment of CITES (Convention on International Trade in Endangered Species of Wild Fauna and Flora) in 1975. We assessed the extent of trade of wild cats in Peru (eight species) using export records available from 1946 to 1973, before the establishment of CITES and after the implementation of CITES using confiscation data available for 2001–2020. The ocelot and the jaguar were the most exploited species for their skins in the pre‐CITES period, with 228,376 and 17,301 individuals, respectively; as well as post‐CITES, although at significantly lower levels, with 67 individuals and 107 body parts, and 27 individuals and 99 body parts, respectively. Post‐CITES trade, however, shows an increasing trend for the jaguar and all wild cat species. Currently in Peru, the illegal wildlife trade is considered opportunistic, but its impact on wild populations has not been properly documented. We recommend improving knowledge regarding population status of wild cats to inform conservation status, and to increase efforts to reduce illegal trade at both national and regional level.
Increase in nuclear cell‐free DNA is associated with major adverse events in adult and pediatric heart transplant recipients
Authors: Zangwill Steven D. , Deshpande Shriprasad R. , Simpson Pippa M. , Liang Huan Ling , Zhang Liyun , Dasgupta Mahua , Richmond Marc E. , Kindel Steven J. , Bichell David P. , Mahle William T. , Wigger Mark A. , Schroder Jacob N. , Knecht Kenneth R. , Pahl Elfriede , Gaglianello Nunzio A. , North Paula E. , Tomita‐Mitchell Aoy , Mitchell Michael E. 
Published: October 2021

AbstractBackgroundCell‐free DNA is an emerging biomarker. While donor fraction may detect graft events in heart transplant recipients, the prognostic value of total nuclear cell‐free DNA (ncfDNA) itself is largely unexplored.ObjectiveExplore the relationship between ncfDNA and clinical events in heart transplant recipients.MethodsWe conducted a multi‐center prospective study to investigate the value of cell‐free DNA in non‐invasive monitoring following heart transplantation. Over 4000 blood samples were collected from 388 heart transplant patients. Total ncfDNA and donor fraction were quantified. Generalized linear models with maximum likelihood estimation for repeated measures with subjects as clusters were used to explore the relationship of ncfDNA and major adverse events. Receiver operating characteristic curves were used to help choose cutpoints.ResultsA ncfDNA threshold (50 ng/ml) was identified that was associated with increased risk of major adverse events. NcfDNA was elevated in patients who suffered cardiac arrest, required mechanical circulatory support or died post heart transplantation as well as in patients undergoing treatment for infection.ConclusionsElevated ncfDNA correlates with risk for major adverse events in adult and pediatric heart transplant recipients and may indicate a need for enhanced surveillance after transplant.
Predictors of length of treatment, discharge reason, and re‐admission to Aboriginal alcohol and other drug residential rehabilitation services in New South Wales, Australia
Authors: James Doug B. , Lee K. S. Kylie , Dronavalli Mithilesh , Courtney Ryan J. , Conigrave Katherine M. , Conigrave James H. , Shakeshaft Anthony 
Published: October 2021

AbstractIntroductionAboriginal clients accessing Aboriginal community‐controlled residential alcohol and other drug rehabilitation services in New South Wales, Australia believe they have better outcomes due to culturally appropriate care. However, there is a paucity of published treatment outcome data. This study aims to identify predictors of treatment outcomes based on client characteristics at intake.MethodsA cross‐sectional, retrospective, observational study of 2326 admissions to six services between January 2011 and December 2016. The outcomes were: (i) leaving treatment early; (ii) self‐discharge or house discharge (by staff); and (iii) re‐admission within two years. The predictors examined were Aboriginal status, age, justice system referral and primary substance of concern. Competing risk and Poisson regression analyses were used to identify trends in the data.ResultsThe mean age of clients was 33 years, and the majority (56%) stayed at least 6 weeks. Aboriginal clients whose primary substance of concern was stimulants were almost eight times more likely to re‐admitted within 2 years than other clients (risk ratio 7.91; P < 0.001). Aboriginal clients who were also referred from justice were more likely to self‐discharge (risk ratio 1.87; P < 0.001). Furthermore, Aboriginal clients who were aged older than 30 were less likely to have a re‐admission (risk ratio 0.32; P ≤ 0.001).Discussion and ConclusionsThis study showed client characteristics that are predictive of harmful outcomes include age under 30, justice client, primary substance of use and their interactions. Future research could build on these results to aid ongoing development of residential rehabilitation programs for Aboriginal peoples.
Use of midostaurin in mixed phenotype acute leukemia with FLT3 mutation: A case series
Authors: Tremblay Zoë , Wong Anna , Otis Anne‐Sophie , Pépin Marie‐Anne , Bambace Nadia , Soulières Denis , Bouchard Philippe , Adam Jean‐Philippe 
Published: October 2021

AbstractMixed phenotype acute leukemia (MPAL) is a rare type of acute leukemia where blasts present phenotypes from more than one lineage. A poor prognostic has been associated with this disease, and limited data are currently available to guide the choice of therapy. Regarding FLT3‐positive MPAL, only one case treated with midostaurin has been published to date. Here, we report the successful use of midostaurin to treat three FLT3‐positive MPAL T/myeloid and B/myeloid patients. Midostaurin was successfully added to intensive induction (two patients) and consolidation chemotherapy (three patients) without significant adverse events requiring a dose adjustment or discontinuation. The therapy received resulted in complete remission for two patients and complete remission with an incomplete hematologic recovery for the third. All patients proceeded to HSCT and stayed in remission after an extended follow‐up respectively at 28, 31, and 11 months later. These results suggest that the addition of midostaurin during induction and consolidation therapy may represent a treatment option for FLT3‐positive MPAL.
Repeated episodes of transient reduction of oxygen exposure simulating aircraft cabin conditions enhance resilience to stress in mice
Authors: Ginerete Roxana Paula , Mascio Giada , Liberatore Francesca , Bucci Domenico , Antenucci Nico , Di Pietro Paola , Cannella Milena , Imbriglio Tiziana , Notartomaso Serena , Nicoletti Ferdinando , Bruno Valeria , Battaglia Giuseppe 
Published: October 2021

AbstractPilots and crew of domestic flights are exposed to transient periods of mild reductions of partial pressure of inspired oxygen each day, and this might have functional consequence on their performance in the long range. Here, we exposed mice to mild reductions of oxygen exposure (ROE) four times per day for 21 days by lowering oxygen partial pressure to levels corresponding to an altitude of about 2300 m, which is the quote of pressurization of the air cabin. Four groups of mice were studied: unstressed or stressed mice exposed to ROE or normoxic conditions. Mice were exposed to chronic unpredictable stress (CUS) for 28 days, and ROE was delivered in the last 21 days of CUS. In normoxic mice, CUS caused anhedonia in the sucrose preference test, anxiety‐like behaviour in the open field test, learning impairment in the Morris water maze, reduced hippocampal neurogenesis, increased serum corticosterone levels and increased expression of depression‐related genes (Pclo, Mthfr and Grm5) in the hippocampus. All these changes were reversed by ROE, which had little or no effect in unstressed mice. These findings suggest that ROE simulating air cabin conditions of domestic flights may enhance resilience to stress improving mood, anxiety and learning ability.
Pilot project for a recovery‐oriented, DBT‐informed skill‐building education course for families of adults with borderline personality, bipolar or major depressive disorders
Authors: Mannion Edie , Lukens Jonathan , Solomon Phyllis , Lowery MaryCatherine , Snitzer Lisa 
Published: October 2021

AbstractThere are a variety of educational interventions for families who have a relative with a mental health disorder. However, for those with one or more emotion dysregulation disorders, there are limited options. This article reports on the results of a pilot project using a quasi‐experimental design with a sample of 270 (intervention = 217, control = 53) to assess an intervention,Getting Off the Emotional Roller Coaster Skill‐Building Family Education Course (GOER Family Course), for families coping with and managing emotion regulation disorders in a loved one which are often misdiagnosed or co‐occurring. This intervention was effective in reducing caregiver burden [F(1, 120) = 12.25,p = 0.001], while improving attitudes, knowledge, and skills [F(1, 170) = 6.16,p = 0.014]. It fills an important gap in available resources for families faced with challenges and responsibilities that these disorders can present, especially when inaccurately diagnosed or receiving ineffective treatment. While there is a need for further research and adaptation to virtual learning, the preliminary results show positive effects.
Day‐to‐day changes and longer‐term adjustments to divorce ideation: Marital commitment uncertainty processes over time
Authors: Allen Sarah , Hawkins Alan J. , Harris Steven M. , Roberts Kelly , Hubbard Aimee , Doman Mattison 
Published: October 2021

AbstractObjectiveThe aim of this study is to use in‐depth, qualitative interviews and longitudinal analysis to explore fluctuations in divorce ideation over time with 30 participants who had thoughts about divorce in the previous 6 months.BackgroundScholarship on marital ambivalence and divorce ideation suggests the importance of better understanding the dialectical tensions involved in navigating the many areas of life affected by marital commitment uncertainty. To model complex relational processes of change over time, researchers need to move beyond contextualized snapshots of relationship outcomes to a more continuous mapping of relationship processes, including changes in emotions, beliefs, and behaviors regarding the future of their marital relationship.MethodsWe completed in‐depth interviews with participants who had recently been thinking about divorce at two times approximately 8 to 10 months apart. Our team used qualitative thematic analysis to elucidate emergent themes and processes.ResultsWe found complex and dynamic patterns of leaning‐in, leaning‐out, and holding‐on emotions, attitudes, and behaviors that suggest theoretical models that may better capture the dynamic process of how commitment uncertainty influences the ways in which married partners think about the future of their marriage.ConclusionThis research can help improve how we theoretically model commitment uncertainty processes embedded in divorce ideation within the complex processes of day‐to‐day and longer term relational changes over time.ImplicationsFamily practitioners and the couples they serve can benefit from expanded conceptualizations of marital commitment outcomes that also include the processes of marital commitment as a way to normalize the ebbs and flows of relationships.