bluuebunny/crossref_metadata_2025_split huggingface dataset:
Muchas gracias
Authors: Equipo editorial de ASEI  
Published: March 2021

El equipo editorial de Actualizaciones en SIDA e Infectología agradece enormemente a los 46 revisores que han dedicado su tiempo y experiencia al cuidadoso proceso editorial de la revista durante los últimos doce meses, independientemente de si los artículos se publicaron finalmente o no. Los editores desean expresar su sincero agradecimiento a los siguientes revisores por su generosa contribución en la evaluación de trabajos durante el año 2020:
Afeltra, JavierÁguila Brunet, DamiánArias, MarianaAtorri, SilviaBalasani, CarinaBarcan, LauraBarcelona, LauraBarreda, VictoriaBonvehí, PabloBottasso, OscarCahn, FlorenciaCahn, PedroContarelli, JorgeCórdova, EzequielCornistein, WandaCorral, GonzaloCortés, ClaudiaCortesse, SilviaCostilla Campero, GustavoCunto, Eleonorade Vedia, LautaroDevicich, GastónDignani, CeciliaFarina, JavierFink, ValeriaGonzález, CarlosLauffer, NataliaLloveras, SusanaLopardo, GustavoMaglio, IgnacioMartini, SergioMauas, RominaMorales, AdriánMykietiuk, AnalíaNacinovich, FranciscoNannini, EstebanNemirovsky, CorinaPeralta, MirtaPryluka, DanielRadusky, PabloRollet, RaquelRüttimann, RicardoSalgueira, ClaudiaStryjewski, MartínTeijeiro, RicardoZylberman, Marcelo
A su vez, el Comité Editorial quiere agradecer especialmente a Ezequiel Córdova, quien durante los últimos meses de 2020 se desempeñó como editor invitado en el número 104 de la revista, dedicado al COVID-19.
Study of efficiency and information transmission for agricultural futures markets: a comparative analysis between Buenos Aires and Chicago using monthly and daily data
Authors: Lachman Jeremías , Jack Pablo 
Published: March 2021

This paper aims to study and compare the efficiency in futures markets for soybean crop between Buenos Aires (MATBA) and Chicago (CME–CBOT) for the years 1994 through 2015. There are numerous studies that analyze this phenomenon independently, but few of them have done a comparative analysis between marke-
ts. Therefore, the main objective of this research — in addition to individually analyzing the efficiency in futures market in each country — is to be able to detect the existence of a relationship between the two markets. In this article we show that, in addition for market efficiency in all cases, market efficiency in MatBa was derived from the efficiency in CME–CBOT. This means that relevant information is transmitted from the Chicago market to the one in Buenos Aires. By using a cointegration approach based on Johansen (1995) we estimated the models with monthly and daily data.
Ciencias del comportamiento y política: tiempo de "empujar" la conducta de los gobernantes
Authors: Linares Sebastián , Freidin Esteban 
Published: March 2021

El enfoque de Behavioral Insights (BI) implica utilizar conocimientos de las ciencias del comportamiento en el diseño, implementación y evaluación de políticas públicas. En general, los proyectos asociados a BI buscan afectar la conducta de los ciudadanos en sentidos socialmente deseables. En este artículo planteamos que el mismo enfoque puede ser utilizado como marco para "pensar" cómo moldear la conducta de los gobernantes con fines prosociales. Con este objetivo, discutimos dos conceptos: 1) la alineación de los incentivos de gobernantes y ciudadanos, y 2) el enfoque Nudge, que implica estructurar los ambientes de decisión para guiar a los agentes hacia fines prosociales. Concluimos mencionando algunas promesas y limitaciones del enfoque BI en general y de nuestras propuestas específicas en particular
Clusters y poject finance. Análisis de su implementación en el departamento de Alto Paraná, Paraguay. Período: 2016-2046
Authors: Riveros González Clara Ruth , Cabral López María Antonella 
Published: March 2021

El objetivo de este artículo es identifi car los benefi cios económicos y sociales de la implementación del Project Finance en un clúster para la producción de stevia en el Departamento de Alto Paraná, Paraguay. Para realizarlo se utilizó el modelo de descuento de fl ujos de caja y se valoró la realización de este proyecto de inversión. Las aportaciones son, por un lado, que se ofrece un modelo de clúster con Project Finance íntegro, con base en la realidad, que convierte los problemas en oportunidades; por otro lado, se busca generar con la propuesta un mayor desarrollo de este tipo de proyectos innovadores.
Integración de la Economía con la Psicología: Richard H. Thaler, Premio Nóbel de Economía 2017
Authors: Vargas Hernández José G. 
Published: March 2021

Este trabajo pretende analizar las principales contribuciones de Richard H. Thaler a la ciencia de la economía del comportamiento, las cuales han sido consideradas para otorgarle el Premio Nobel Sveriges Riksbank de Economía en 2017. Sus aportaciones incorporan la psicología en los procesos de tomas de decisiones económicas apartándose de la racionalidad instrumental y la teoría de la elección racional para contribuir a la generación de una nueva perspectiva en la teoría económica y en la política económica. El método empleado es fundamentalmente el analítico-descriptivo basado en una revisión de sus principales publicaciones realizadas. Finalmente se concluye que Thaler y sus colaboradores ejercen una infl uencia relevante al generar un nuevo marco de referencia para explicar y predecir resultados económicos desde un acercamiento del comportamiento racional limitado, la teoría de contabilidad limitada y el modelo de planeador-hacedor bajo el concepto de empujón o nudge, el cual tiene un impacto en el diseño e implementación de las políticas públicas.
Los sistemas de gestión predial: diferencias en eficiencia técnica y brechas tecnológicas en los tambos de Uruguay
Authors: García Suárez Federico , Pérez Quesada Gabriela 
Published: March 2021

El presente estudio analiza las diferencias tecnológicas entre dos grupos de productores de leche, familiares (PF) y con manejo empresarial (PME). Para obtener estimaciones de eﬁ ciencia técnica comparables entre los dos grupos se utiliza la metodología de meta-fronteras. Aunque los PME son técnicamente más eﬁ cientes que los PF (0.702 y 0.487, respectivamente) ambos grupos podrían obtener un mayor nivel de productividad mejorando su eﬁ ciencia técnica. Además, cada no de los grupos opera bajo diferentes condiciones tecnológicas. El valor promedio del meta-ratio es 0.911 para los PME y 0.807 para los PF. Por lo tanto, los PME deberían invertir en nuevas tecnologías para reducir la brecha tecnológica, mientras que los PF podrían implementar las prácticas y tecnologías prevalecientes que están siendo usadas por los PME.
Analisis kelimpahan E.coli dan bakteri Patogen sebagai indikator penurunan kualitas perairan pada budidaya keramba apung ikan patin desa Buluh Cina Kabupaten Kampar
Authors: Rifai Mumin , Zulkarnaini Zulkarnaini , Siregar Sofyan Husein 
Published: March 2021

The research on Escherichia coli (E. coli) and bacterial pathogens within catfish culture in Buluh Cina Village has been done in August 2015. This study aimed to analyze the quality of the river water, the abundance of E.coli in the water stream and pathogenic bacteria in catfish and to correlate the quality of the water with an abundance of E. coli and the prevalence of pathogenic bacteria. The location of the study is three observation stations with sampling conducted by three replications. The water quality parameters under investigation were temperature, brightness, pH, DO, Nitrate, Nitrite, Ammonia, Phosphate, TSS and BOD while the indicator for microbiological contamination is done by testing the abundance of E. coli in the river water as well as the pathogenic bacteria in catfish. The results of water quality measurements and testing of E. coli indicate the water quality is still good with the standard required under Regulation No 82/2001 except ammonia, phosphates, nitrites and E. coli. Ammonia has exceeded the threshold value with the average from 0.018 to 0.059 mg/L, the phosphate on the average value of 4,921 to 9,804 mg/L, nitrite in the average value from 0.015 to 0.068 mg/L and the abundance of E. coli on the value of the average 4,200-5,500 cfu / 100 ml. While the results of testing on pathogenic bacteria found in catfish are Aeromonas sp, Pseudomonas sp, Pasteurella sp and Edwardsiella sp. The highest prevalence of pathogenic bacteria obtained in Aeromonas sp is equal to 29.63%. In the statistical test toward chemical parameters of water measured affects the abundance of E. coli by 94%. The most significant variable on the water quality parameters affecting the abundance of E. coli is the temperature, TSS, pH, and DO with a correlation coefficient 0.5.
Kajian potensi dan pengembangan ekowisata hutan mangrove di bandar Bakau Puteri Tujuh, Kota Dumai, Provinsi Riau
Authors: Fakhrurrozi Fakhrurrozi , Siregar Yusni Ikhwan , Zulkarnaini Zulkarnaini 
Published: March 2021

Mangrove forest area, Bandar Bakau Puteri Tujuh in Dumai City has been developed into the ecotourism forests. Empirical experience as well as issues about Bandar Bakau Puteri Tujuh such as: tourist motivation mangrove ecotourism activity, environmental pollution and is deemed necessary taken a study to the development of potentials. The main purpose of this research is: (1) to analize factor that attract tourist to conduct mangrove ecotourism activity in mangrove forest Bandar Bakau Puteri Tujuh area (2) calculate carrying capacity mangrove forests area (3) to provide sustainable mangrove forestsecotourism in Puteri Tujuh area. Survey on qualitative and descriptive approachwere done this study.Data were collected in the questionnaire and deep interview method. The research was carried out in August-Oktober 2015. It appeared that: factor attracting tourists to visit included the hospitality with result 91% tourists argues. Characteristics of the are were of suitable for education ecotourism activity and scenery enjoy ecotourism activity. It is suggestedto create sustainable mangrove ecotourism in Bandar BakauPuteriTujuh (1) Which need to developing more ecotourism activity for tourist. 2) Goverment with area organizer must be add to availability and repair facilities ecotourism mangrove activity (3) Need to Dumai City goverment regulations allotment status area and space arrangement plan Bandar BakauPuteriTujuh sphere as ecotourism mangrove area. 4) Hand over construct and specifically training for organizer about ecotourism development in cohesiveness
Internal Flow Choking in Cardiovascular System: A Radical Theory in the Risk Assessment of Asymptomatic Cardiovascular Diseases
Authors: Raghavapanicker Sanal Kumar Valsalayam , Kumar Choudhary Shiv , Kumar Radhakrishnan Pradeep , Sundararam Bharath Rajaghatta , Chandrasekaran Nichith , Sankar Vigneshwaran , Sukumaran Ajith , Oommen Charlie 
Published: March 2021

The theoretical discovery of Sanal flow choking in the cardiovascular system (CVS) demands for interdisciplinary studies and universal actions to propose modern medications and to discover new drugs to annul the risk of flow-choking leading to shock-wave generation causing asymptomatic-cardiovascular-diseases. In this chapter we show that when blood-pressure-ratio (BPR) reaches the lower-critical-hemorrhage-index (LCHI) the flow-choking could occur in the CVS with and without stent. The flow-choking is uniquely regulated by the biofluid/blood-heat-capacity-ratio (BHCR). The BHCR is well correlated with BPR, blood-viscosity and ejection-fraction. The closed-form analytical models reveal that the relatively high and the low blood-viscosity are cardiovascular-risk factors. In vitro data shows that nitrogen, oxygen, and carbon dioxide gases are predominant in fresh blood samples of the human being/Guinea-pig at a temperature range of 37–40 °C (98.6–104 °F). In silico results demonstrate the occurrence of Sanal flow choking leading to shock wave generation and pressure-overshoot in CVS without any apparent occlusion. We could conclude authoritatively, without any ex vivo or in vivo studies, that the Sanal flow choking in CVS leads to asymptomatic-cardiovascular-diseases. The cardiovascular-risk could be diminished by concurrently lessening the viscosity of biofluid/blood and flow-turbulence by increasing the thermal-tolerance level in terms of BHCR and/or by decreasing the BPR.
Patterns of Translocation Testing in Patients Enrolling in a Cooperative Group Trial for Newly Diagnosed Metastatic Ewing Sarcoma
Authors: DuBois Steven G. , Krailo Mark D. , Buxton Allen , Lessnick Stephen L. , Teot Lisa A. , Rakheja Dinesh , Crompton Brian D. , Janeway Katherine A. , Gorlick Richard G. , Glade-Bender Julia 
Published: March 2021

Context.—
Molecular diagnostics play an increasing role in the diagnosis of Ewing sarcoma. The type of molecular testing used in clinical practice has been poorly described.

Objective.—
To describe patterns of translocation testing for newly diagnosed Ewing sarcoma.

Design.—
Children's Oncology Group (COG) trial AEWS1221 was a phase III randomized trial enrolling patients with newly diagnosed metastatic Ewing sarcoma from 2014 to 2019. Patients were required to have a histologic diagnosis of Ewing sarcoma, but translocation testing was not required. Sites provided types and results of any molecular diagnostics performed.

Results.—
Data from 305 enrolled patients were available. The most common type of molecular testing was fluorescence in situ hybridization (FISH) performed on the primary tumor (236 of 305 patients; 77.4%), with positive testing for an EWSR1 or FUS translocation in 211 (89.4%). Reverse transcription–polymerase chain reaction (RT-PCR) on the primary tumor was performed in 61 of 305 patients (20%), with positive results in 48 of 61 patients (78.7%). Next-generation sequencing was reported in 7 patients for the primary tumor and in 3 patients for metastatic sites. For all types of testing on either primary or metastatic tumor, 16 of 305 patients (5.2%) had no reported translocation testing. When evaluating all results from all testing, 44 of 305 patients (14.4%) lacked documentation of an abnormality consistent with a molecular diagnosis of Ewing sarcoma.

Conclusions.—
COG sites enrolling in a Ewing sarcoma trial have high rates of testing by FISH or PCR. A small proportion of patients have no translocation testing on either primary or metastatic sites. Next-generation sequencing techniques are not yet commonly used in this context.
Changes in Test Volumes During Coronavirus Disease 2019 (COVID-19): A Laboratory Stewardship Opportunity
Authors: Singh Ila R. , Dowlin Michael , Chong Thomas H. , Nakamoto Jon M. , Hilborne Lee H. 
Published: March 2021

Context.—
Coronavirus disease 2019 (COVID-19) changed the dynamics of health care delivery, shifting patient priorities and deferring care perceived as less urgent. Delayed or eliminated care may place patients at risk for adverse outcomes.

Objective.—
To identify opportunities for laboratory test stewardship to close potential gaps in care created by the COVID-19 pandemic.

Design.—
The study was a retrospective time series design examining laboratory services received before and during the COVID-19 pandemic at a large metropolitan health system serving women and children.

Results.—
Laboratory test volumes displayed 3 distinct patterns: (1) a decrease during state lockdown, followed by near-complete or complete recovery; (2) no change; and (3) a persistent decrease. Tests that diagnose or monitor chronic illness recovered only partially. For example, hemoglobin A1c initially declined 80% (from 2232 for April 2019 to 452 for April 2020), and there was a sustained 16% drop (28-day daily average 117 at August 30, 2019, to 98 at August 30, 2020) 4 months later. Blood lead dropped 39% (from 2158 for April 2019 to 1314 for April 2020) and remained 23% lower after 4 months.

Conclusions.—
The pandemic has taken a toll on patients, practitioners, and health systems. Laboratory professionals have access to data that can provide insight into clinical practice and identify pandemic-related gaps in care. During the pandemic, the biggest patient threat is underuse, particularly among tests to manage chronic diseases and for traditionally underserved communities and people of color. A laboratory stewardship program, focused on peri-pandemic care, positions pathologists and other laboratory professionals as health care leaders with a commitment to appropriate, equitable, and efficient care.
Chlorophyll Content in Leaves of Wheat as Influenced by Inorganic, Organic and Integrated Sources of Nutrient Application
Authors: Vishwakarma Megha , Kulhare P. S. , Tagore G. S. 
Published: March 2021

Field experiments were conducted during winter season of 2018-19 and 2019-20 with three sources of nutrient viz., inorganic, organics (FYM, VC and biofertilizers) and their integration as main treatments and five levels [S1-0 (0-0-0 kg NPK ha-1), S2-100% (120-60-40 kg NPK ha-1), S3-150% (180-90-60 kg NPK ha-1), S4-200% (240-120-80 kg NPK ha-1) and S5-Soil Test based (STV) NPK i.e. 149-176-33 kg ha-1 in split plot design with three replications. The chlorophyll content (‘a’, ‘b’ and total) in leaves and Soil Plant Analyzer Development (SPAD) value were recorded at crown root initiation (CRI), tillering, jointing and milking stage of wheat. The pooled data of findings revealed that the treatment with inorganic sources showed significant increase in the SPAD readings (9.62, 15.54, 23.77 and 29.83), chlorophyll ‘a’ (0.76, 0.83, 1.47 and 0.63 mg g-1 leaf tissue), ‘b’ (0.44, 0.78, 0.87 and 0.57 mg g-1 leaf tissue) and total (1.19, 1.64, 2.25 and 1.14 mg g-1 leaf tissue) chlorophyll content in leaves over organic source at all the growth stages.
All the levels of nutrient were significantly increased the chlorophyll content and SPAD value over control at all the stages except chlorophyll ‘a’ at jointing and milking stage. However, amongst the levels 150% and 200% NPK were found significantly superior to 100% NPK for SPAD value (8.32 and 8.71 at CRI and 12.56 and 12.19 at tillering), chlorophyll ‘a’ (0.73 and 0.70 mg g-1 leaf tissue at CRI), chlorophyll ‘b’ (0.46 and 0.45 mg g-1 leaf tissue at CRI, 0.68 and 0.71 mg g-1 leaf tissue at tillering and 0.53 and 0.59 mg g-1 leaf tissue at milking), respectively.
The interaction results suggested that the 200% NPK with inorganic and integrated sources significantly superior to 100% NPK for chlorophyll ‘a’ content at jointing and milking stage. The application of 150% and 200% NPK with inorganic source were found significantly higher over the same level of NPK with integrated source of nutrient for total chlorophyll content and SPAD value at all the growth stages except 150% NPK for total chlorophyll at jointing and milking stage and SPAD value at milking stage. The correlation between SPAD value and chlorophyll ’a’, ‘b’, total were found significantly and positively at all growth stages. Coefficient of determination values between SPAD and chlorophyll content showed linear relationship at all the growth stages.
Antitumor effects of low‐dose tipifarnib on the mTOR signaling pathway and reactive oxygen species production in HIF‐1α‐expressing gastric cancer cells
Authors: Egawa Noriyuki , Tanaka Tomokazu , Matsufuji Shohei , Yamada Kohei , Ito Kotaro , Kitagawa Hiroshi , Okuyama Keiichiro , Kitajima Yoshihiko , Noshiro Hirokazu 
Published: March 2021

Farnesyltransferase inhibitors (FTIs) suppress tumor aggressiveness in several malignancies by inhibiting Ras signaling. However, treatment of cells with a low dose of the FTI tipifarnib suppresses the expression of hypoxia‐inducible factor‐1α (HIF‐1α) and results in antitumor effects without inhibiting the Ras pathway. Although we previously reported that elevated HIF‐1α expression is associated with an aggressive phenotype in gastric cancer (GC), little is known about the antitumor effects of FTIs on GC. In this study, we examined the relationship between the antitumor effects of low‐dose tipifarnib and HIF‐1α expression in GC cells. Under normoxic conditions, HIF‐1α was expressed only in MKN45 and KATOIII cells. The inhibitory effect of tipifarnib on HIF‐1α was observed in HIF‐1α‐positive cells. Low‐dose tipifarnib had antitumor effects only on HIF‐1α‐positive cells both in vitro and in vivo. Furthermore, low‐dose tipifarnib inactivated ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) signaling and decreased intracellular reactive oxygen species (ROS) levels in HIF‐1α‐positive GC cells. Our results that the antitumor effects of low‐dose tipifarnib are at least partially mediated through suppression of mTOR signaling and HIF‐1α expression via inhibition of Rheb farnesylation and reduction in ROS levels. These findings suggest that low‐dose tipifarnib may be capable of exerting an antitumor effect that is dependent on HIF‐1α expression in GC cells. Tipifarnib may have potential as a novel therapeutic agent for HIF‐1α‐expressing GC exhibiting an aggressive phenotype.
Moving out of town? The status of alien plants in high‐Arctic Svalbard, and a method for monitoring of alien flora in high‐risk, polar environments
Authors: Bartlett Jesamine C. , Westergaard Kristine Bakke , Paulsen Ingrid M. G. , Wedegärtner Ronja E. M. , Wilken Florian , Ravolainen Virve 
Published: March 2021

Abstract
Rising human activity in the Arctic, combined with a warming climate, increases the probability of introduction and establishment of alien plant species. While settlements are known hotspots for persistent populations, little is known about colonization of particularly susceptible natural habitats. Systematic monitoring is lacking and available survey methods vary greatly.
Here, we present the most comprehensive survey of alien vascular plant species in the high‐Arctic archipelago of Svalbard to date, aimed at (i) providing a status within settlements; (ii) surveying high‐risk habitats such as those with high visitor numbers and nutrient enrichment from sea bird colonies; (iii) presenting a systematic monitoring method that can be implemented in future work on alien plant species in Arctic environments; and (iv) discuss possibilities for mapping alien plant habitats using unmanned aerial vehicles.
The systematic grid survey, covering 1.7 km2 over three settlements and six bird cliffs, detected 36 alien plant species. Alien plant species were exclusively found in areas of human activity, particularly areas associated with current or historic animal husbandry. The survey identified the successful eradication of Anthriscus sylvestris in Barentsburg, as well as the rapid expansion of Taraxacum sect. Ruderalia over the last few decades.
As there is currently no consistent method for monitoring alien plant species tailored to polar environments, we propose a systematic methodology that could be implemented within a structured monitoring regime as part of an adaptive monitoring strategy towards alien species in the Arctic.