bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 and VILI: developing a mobile app for measurement of mechanical power at a glance
Authors: Senzi Angelo , Bindi Marco , Cappellini Iacopo , Zamidei Lucia , Consales Guglielmo 
Published: February 2021

AbstractThe COVID-19 pandemic has increased the need for a bedside tool for lung mechanics assessment and ventilator-induced lung injury (VILI) monitoring. Mechanical power is a unifying concept including all the components which can possibly cause VILI (volume, pressures, flow, respiratory rate), but the complexity of its mathematical computation makes it not so feasible in routine practice and limits its clinical use. In this letter, we describe the development of a mobile application that allows to simply measure power associated with mechanical ventilation, identifying each component (respiratory rate, resistance, driving pressure, PEEP volume) as well. The major advantage, according to the authors who developed this mathematical description of mechanical power, is that it enables the quantification of the relative contribution of its different components (tidal volume, driving pressure, respiratory rate, resistance). Considering the potential role of medical apps to improve work efficiency, we developed an open source Progressive Web Application (PWA), named “PowerApp” (freely available at https://mechpower.goodbarber.app), in order to easily obtain a bedside measurement of mechanical power and its components. It also allows to predict how the modification of ventilatory settings or physiological conditions would affect power and each relative component. The "PowerApp" allows to measure mechanical power at a glance during mechanical ventilation, without complex mathematical computation, and making mechanical power equation useful and feasible for everyday clinical practice.
Characteristics of tuff breccia-andesite in diverse mechanisms of landslides in Oita Prefecture, Kyushu, Japan
Authors: ISTIYANTI Mega Lia , GOTO Satoshi , Ochiai Hirotaka 
Published: February 2021

AbstractHeavy rainfall frequently occurred in Kyushu and triggers the landslides every year. This study observes the landslides which occurred in Oita Prefecture, Kyushu, Japan. The landslides in this study, consisting of the same soil materials, tuff breccia and andesite materials; however, the landslide mechanisms were different. Two landslides occurred caused by heavy rainfall in the different timing of the landslide occurrence, and another landslide occurred without the heavy rainfall or an earthquake occurs. Therefore, this study aims to analyse the physical and mechanical properties of tuff breccia and andesite materials with diverse landslide mechanisms. This study performed soil stratigraphic analysis and soil hardness measurements in the field, and performed physical properties, saturated permeability, mechanical properties, and XRD tests in the laboratory. This study found that characteristics of tuff breccia and andesite in diverse mechanisms of landslides were not very different, especially on the landslides caused by heavy rainfall. Furthermore, the landslide in the andesite and tuff breccia areas could be divided into three types based on the timing of the landslide occurrence, scale of the landslide, and landslide mechanisms.
The clinical relevance of luteal phase progesterone support in true natural cycle cryopreserved blastocyst stage embryo transfers: a retrospective cohort study
Authors: Waldman Ian N. , Racowsky Catherine , Disler Emily R. , Thomas Ann , Lanes Andrea , Hornstein Mark D. 
Published: February 2021

Abstract
Background
More than 67% of all embryos transferred in the United States involve frozen-thawed embryos. Progesterone supplementation is necessary in medicated cycles to luteinize the endometrium and prepare it for implantation, but little data is available to show if this is beneficial in true natural cycles. We evaluated the use of luteal phase progesterone supplementation for cryopreserved/warmed blastocyst transfers in true natural cycles not using an ovulatory trigger.

Methods
Retrospective cohort study in a single academic medical center. We studied the use of luteal phase progesterone supplementation in patients undergoing true natural cycle cryopreserved blastocyst embryo transfers. Our primary outcome measure was ongoing pregnancy rate, with other pregnancy outcomes being evaluated (i.e. implantation rate, miscarriage rate, ectopic rate, and multifetal gestation). Categorical data were analyzed utilizing Fisher’s exact test and all binary variables were analyzed using log-binomial regression to produce a risk ratio.

Results
Two hundred twenty-nine patients were included in the analysis with 149 receiving luteal phase progesterone supplementation and 80 receiving no luteal phase support. Patient demographic and cycle characteristics, and embryo quality were similar between the two groups. No difference was seen in ongoing pregnancy rate (49.0% vs. 47.5%, p = 0.8738), clinical pregnancy rate (50.3% vs. 47.5%, p = 0.7483), positive HCG rate (62.4% vs. 57.5%, p = 0.5965), miscarriage/abortion rate (5.4% vs. 2.5%, p = 0.2622), ectopic pregnancy rate (0% vs. 1.3%, p = 0.3493), or multifetal gestations (7.4% vs. 3.8%, p = 0.3166).

Conclusion(s)
The addition of luteal phase progesterone support in true natural cycle cryopreserved blastocyst embryo transfers did not improve pregnancy outcomes and therefore the routine use in practice cannot be recommended based on this study, but the utilization should not be discouraged without further studies.

Capsule
Progesterone supplementation as luteal phase support in true natural cycle cryopreserved blastocyst transfers does not improve ongoing pregnancies.
Post-traumatic stress disorder symptoms in COVID-19 survivors: online population survey
Authors: Chamberlain Samuel R. , Grant Jon E. , Trender William , Hellyer Peter , Hampshire Adam 
Published: February 2021

Summary
This study examined post-traumatic stress disorder (PTSD) symptoms in 13 049 survivors of suspected or confirmed COVID-19, from the UK general population, as a function of severity and hospital admission status. Compared with mild COVID-19, significantly elevated rates of PTSD symptoms were identified in those requiring medical support at home (effect size 0.178 s.d., P = 0.0316), those requiring hospital admission without ventilation (effect size 0.234 s.d., P = 0.0064) and those requiring hospital admission with ventilator support (effect size 0.454 s.d., P < 0.001). Intrusive images were the most prominent elevated symptom. Adequate psychiatric provision for such individuals will be of paramount importance.
Life Without Thyroid Hormone Receptor
Authors: Shi Yun-Bo 
Published: February 2021

Abstract
Thyroid hormone (T3) is critical not only for organ function and metabolism in the adult but also for animal development. This is particularly true during the neonatal period when T3 levels are high in mammals. Many processes during this postembryonic developmental period resemble those during amphibian metamorphosis. Anuran metamorphosis is perhaps the most dramatic developmental process controlled by T3 and affects essentially all organs/tissues, often in an organ autonomous manner. This offers a unique opportunity to study how T3 regulates vertebrate development. Earlier transgenic studies in the pseudo-tetraploid anuran Xenopus laevis revealed that T3 receptors (TRs) are necessary and sufficient for mediating the effects of T3 during metamorphosis. Recent gene knockout studies with gene-editing technologies in the highly related diploid anuran Xenopus tropicalis showed, surprisingly, that TRs are not required for most metamorphic transformations, although tadpoles lacking TRs are stalled at the climax of metamorphosis and eventually die. Analyses of the changes in different organs suggest that removal of TRs enables premature development of many adult tissues, likely due to de-repression of T3-inducible genes, while preventing the degeneration of tadpole-specific tissues, which is possibly responsible for the eventual lethality. Comparison with findings in TR knockout mice suggests both conservation and divergence in TR functions, with the latter likely due to the greatly reduced need, if any, to remove embryo/prenatal-specific tissues during mammalian postembryonic development.
The “Latin” Melting Pot
Authors: Tal Yuval 
Published: February 2021

AbstractThis article explores how, through discussions about immigrant assimilation in fin de siècle Algeria, French republicans contemplated and wrote into law the ethnic traits of French national identity. Republicans assumed that the North Mediterranean immigrants who settled in Algeria shared ethnic origins with French settlers and consequently asserted that France should work to “fuse” the two groups. Assertions about immigrants' ethnicity took different forms. In the colony they appeared either at the margins of colonial administrators' attacks against immigrant communal organization or in literary representations of French-Mediterranean fusion. In the metropole republican legislators portrayed immigrants as innately prone to becoming French and thus supported the 1889 nationality law that naturalized them. The passing of the 1889 law prompted the creation of an explicitly ethnorepublican assimilatory model. The model's proponents combined sociological and eugenicist principles to both socialize immigrants into the nation and promote the transfer of their Mediterranean “vigor” into French bodies.Cet article examine les efforts des intellectuels et des dirigeants républicains pour assimiler les immigrés européens en Algérie à la fin du dix-neuvième siècle. Il affirme que les identités communautaires et la prépondérance démographique des immigrés ont poussé l'élite républicaine à envisager leur capacité ethnique à s'assimiler à la société française, et montre que l'idée que les Français et les immigrés avaient la même origine ethnique a façonné les débats sur l'assimilation nationale et a influencé la formation des lois républicaines fondamentales. En Algérie, des affirmations à propos de l'identité ethnique des immigrés européens apparaissaient en marge des discussions politiques sur leur organisation communautaire et dans les romans des écrivains algérianistes. En métropole, des législateurs républicains supposaient que la « ressemblance ethnique » entre Français et immigrés assurait l'assimilation rapide de ces derniers et ils ont soutenu la loi de 1889 sur la nationalité qui les a naturalisés. A l'issue de la législation de 1889, une vision de fusionnement des colons français et des membres de la « race méditerranéenne » en Algérie s'est développée. Ses partisans ont combiné des principes sociologiques avec des principes eugéniques dans le but d'incorporer les immigrés européens dans la nation et de faire transporter leur « vigueur » dans les corps des Français.
Expelling the “Sinister Vilgrain”
Authors: Yackee Jason 
Published: February 2021

AbstractThis article tells the story of the Congo-Brazzaville's nationalization in 1970 of the Société Industrielle et Agricole du Niari (SIAN) and its affiliate Société Sucrière du Niari. At the time of independence, the company, controlled by France's Vilgrain family, was the Congo's largest private employer. The SIAN episode is fertile ground for exploring the theme of postcolonial entanglements from a political-economic perspective. It especially illustrates how those entanglements created both obstacles to and opportunities for neo-imperial influence, just as they did for acts of sovereign independence. The article suggests that the complex, multifaceted interdependencies among France, the Congo, and the Vilgrain family insulated the effects of nationalization on the larger Franco-Congolese relationship while eventually providing a measure of compensation for the despoiled investors.Cet article raconte l'histoire de la nationalisation en 1970 de la Société industrielle et agricole du Niari (SIAN) et sa société affiliée SOSUNIARI par le Congo-Brazzaville. A l'indépendance la SIAN—une entreprise sucrière contrôlée par la famille française Vilgrain—était l'employeur privé le plus important du pays. L'affaire SIAN nous offre un terrain privilégié pour explorer le thème de l'enchevêtrement politique et économique des anciens et nouveaux pouvoirs dans la période postcoloniale. Elle illumine comment ces enchevêtrements fournissaient des occasions pour, et posaient des obstacles à, l'influence néo-impériale et l'indépendance souveraine. L'article conclut que l'interdépendance de la France, du Congo, et de la famille Vilgrain servait à isoler les effets de la nationalisation sur leurs relations plus larges tout en assurant, après un certain délai, une mesure non-dérisoire d'indemnisation pour l'investisseur spolié.
The role of contrast-enhanced ultrasound in the diagnosis of malignant non-mass breast lesions and exploration of diagnostic criteria
Authors: Zhang Fan , Jin Lifang , Li Gang , Jia Chao , Shi Qiusheng , Du Lianfang , Wu Rong 
Published: February 2021

Objectives:
To assess the value of contrast-enhanced ultrasound (CEUS) for diagnosing malignant non-mass breast lesions (NMLs) and to explore the CEUS diagnostic criteria.

Methods:
A total of 116 patients with 119 NMLs detected by conventional US were enrolled. Histopathological results were used as the reference standard. The enhancement characteristics of NMLs in CEUS were compared between malignant and benign NMLs. The CEUS diagnostic criteria for malignant NMLs were established using independent diagnostic indicators identified by binary logistic regression analysis. The diagnostic performance of Breast Imaging Reporting and Data System-US (BI-RADS-US), CEUS, and BI-RADS-US combined with CEUS was evaluated and compared.

Results:
Histopathological results showed 63 and 56 benign and malignant NMLs. Enhancement degree (OR = 5.75, p = 0.003), enhancement area (OR = 4.25, p = 0.005), and radial or penetrating vessels (OR = 7.54, p = 0.003) were independent diagnostic indicators included to establish the CEUS diagnostic criteria. The sensitivity and specificity of BI-RADS-US, CEUS, and BI-RADS-US combined with CEUS were 100 and 30.2%, 80.4 and 74.6%, and 94.6 and 77.8%, respectively; the corresponding areas under the receiver operating characteristic curve (AUC) were 0.819, 0.775, and 0.885, respectively.

Conclusions:
CEUS has a high specificity in malignant NML diagnosis based on the diagnostic criteria including enhancement degree, enhancement area, and radial or penetrating vessels, but with lower sensitivity than BI-RADS-US. The combination of CEUS and BI-RADS-US is an effective diagnostic tool with both high sensitivity and specificity for the diagnosis of malignant NMLs.

Advances in knowledge:
In this study, we assessed the diagnostic value of CEUS for malignant NMLs and constructed a feasible diagnostic criterion. We further revealed that the combination of CEUS and BI-RADS-US has a high diagnostic value for malignant NMLs.
Radiology for medical students: Do we teach enough? A national study
Authors: Chew Cindy , O'Dwyer Patrick J , Sandilands Euan 
Published: February 2021

Objective
A recent study has shown that the averaged time tabled teaching for a medical student across 5 years in the UK was 4629 hours. Radiology has been demonstrated to be an excellent teaching source, yet the number of hours allocated to this has never been calculated.
The aims of this study were to evaluate and quantify the hours allocated to radiology teaching in Scottish Medical Schools and to evaluate if they can fulfil requirements expected from other Clinical disciplines and the upcoming General Medical Council Medical Licensing Assessment (GMC MLA).

Methods
Data pertaining to timetabled teaching for Radiology in Scottish Universities were obtained from the authors of the Analysis of Teaching of Medical Schools (AToMS) survey. In addition, University Lead Clinician Teachers were surveyed on the radiological investigations and skills medical students should have at graduation.

Results
Medical students in Scottish Universities were allocated 59 h in Radiology (0.3%) out of a total 19,325 h of timetabled teaching. Hospital-based teaching was variable and ranged from 0 to 31 h. Almost half (15 of 31) of Clinician Teachers felt that there was insufficient radiology teaching in their specialty. Thirteen of 30 conditions included in the GMC MLA were listed by Clinician Teachers, while 23 others not listed by the GMC were considered important and cited by them.

Conclusion
This study demonstrates that medical students do not receive enough radiology teaching. This needs to be addressed by Universities in collaboration with the NHS in an effort to bring up this up to line with other developed countries and prepare students for the GMC MLA.

Advances in knowledge
(1) There is insufficient time allocated in Medical Students’ curriculum to Radiology.
(2) Radiology teaching in medical schools fall short of University Lead Clinician Teachers’ and GMC expectations of medical students at graduation.
Infection patterns of endemic human coronaviruses in rural households in coastal Kenya
Authors: Nyaguthii Dickson Machira , Otieno Grieven P. , Kombe Ivy K. , Koech Dorothy , Mutunga Martin , Medley Graham F. , Nokes D. James , Munywoki Patrick K. 
Published: February 2021

Background: The natural history and transmission patterns of endemic human coronaviruses are of increased interest following the emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Methods: In rural Kenya 483 individuals from 47 households were followed for six months (2009-10) with nasopharyngeal swabs collected twice weekly regardless of symptoms. A total of 16,918 swabs were tested for human coronavirus (hCoV) OC43, NL63 and 229E and other respiratory viruses using polymerase chain reaction. Results: From 346 (71.6%) household members, 629 hCoV infection episodes were defined, with 36.3% being symptomatic: varying by hCoV type and decreasing with age. Symptomatic episodes (aHR=0.6 (95% CI:0.5-0.8) or those with elevated peak viral load (medium aHR=0.4 (0.3-0.6); high aHR=0.31 (0.2-0.4)) had longer viral shedding compared to their respective counterparts. Homologous reinfections were observed in 99 (19.9%) of 497 first infections. School-age children (55%) were the most common index cases with those having medium (aOR=5.3 (2.3 – 12.0)) or high (8.1 (2.9 - 22.5)) peak viral load most often generating secondary cases. Conclusion: Household coronavirus infection was common, frequently asymptomatic and mostly introduced by school-age children. Secondary transmission was influenced by viral load of index cases. Homologous-type reinfection was common. These data may be insightful for SARS-CoV-2.
Supplier Encroachment in a Nonexclusive Reselling Channel
Authors: Hotkar Parshuram , Gilbert Stephen M. 
Published: February 2021

We consider a setting in which a nonexclusive reseller procures partially substitutable products from two suppliers, one of whom introduces a direct channel. We find that the presence of the second supplier alters many of the existing results about the interactions between a reseller and an encroaching supplier. For instance, the reseller’s and the supply chain’s benefit from the direct channel disappears when the product substitutability is sufficiently large. In addition, when the reseller is nonexclusive, the encroaching supplier may either sell exclusively through its direct channel even when that channel is less efficient than the reselling channel, or sell through both channels even when its direct channel is more efficient than the reselling channel. Neither of these would occur in an exclusive reselling environment with only one supplier. This paper was accepted by Jayashankar Swaminathan, operations management.
Prevalence of dyslipidemia and associated risk factors among adult residents of Mekelle City, Northern Ethiopia
Authors: Gebreegziabiher Gebremedhin , Belachew Tefera , Mehari Kibrti , Tamiru Dessalegn 
Published: February 2021

Introduction
Dyslipidemia is a major risk factor for cardiovascular diseases (CVD). The prevalence of dyslipidemia is not known among Ethiopian adults. The prevalence is expected to rise due to the socio-economic development accompanied by lifestyle changes. This study was conducted to estimate the prevalence of dyslipidemia and associated risk factors among adult residents of Mekelle City.

Methods
A community-based cross-sectional study was conducted among 321 randomly selected subjects. Data were collected on sociodemographic, anthropometric, lifestyle, and clinical characteristics of the participants using the WHO STEPS survey instrument. Data were analyzed using SPSS software version 24.0. Student’s t-test and Pearson’s Chi-square test were used to assessing the interrelationship between each factor and outcome variables. Bivariate and multivariable logistic regression analysis were used to identify risk factors associated with dyslipidemia. All statistical significance was considered at p ≤0.05.

Results
The prevalence of dyslipidemia in this study was 66.7%. The prevalence of high low-density lipoprotein cholesterol (LDL-C), elevated triglyceride, elevated total cholesterol, and low high-density lipoprotein cholesterol (HDL-C) was 49.5%, 40.2%, 30.8%, and 16.5%, respectively. Being above 64 years (aOR: 2.196, 95% CI: 1.183–4.078) and 40–64 years old (aOR: 2.196, 95% CI: 1.183–4.078), overweight (aOR: 2.50, 95% CI: 1.314–4.756) and obesity (aOR: 15.489, 95% CI: 3.525–68.070), walking <150 minutes per week (aOR: 1.722, 95% CI: 1.004–2.953), raised fasting blood glucose (FBG) (aOR: 4.804, 95% CI: 1.925–11.988), and medium socio-economic status (aOR: 2.017, 95% CI: 1.044–3.899) were identified as significant predictors of dyslipidemia.

Conclusions
The finding of this study indicated that the prevalence of dyslipidemia is unacceptably high among adult residents of Mekelle City, which underlines an urgent need for early detection and public health interventions through the integrated involvement of public, governmental, and non-governmental organizations.