bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary Signal Phase Suppression Technique Based On Mutual Information Improved Variational Mode Decomposition
Authors: Yue Jiaying , Wang Sheng , Lyu Pinpin 
Published: September 2021

Abstract
Specific emitter identification (SEI) identifies targets mainly by unintentional modulation of the signal. However, due to the high energy of the primary signal, once the primary signal changes, the recognition becomes less effective or even impossible using a feature database that is not updated. In this paper, we propose to use a mutual information improved variable mode decomposition (VMD) algorithm to suppress the primary signal phase of the transmitter. Furthermore, we simulate the feature extraction of the unintentional phase modulation of the transmitter signal and use support vector machine (SVM) for individual identification. The simulation results show that the algorithm improves the recognition rate by about 6% (0 dB) compared to the retained primary signal. The results demonstrate that our proposed phase suppression technique improves the adaptability and accuracy of individual identification of transmitters.
The Tough Fibrous Tissue of The Supracondylar Groove As A Useful Landmark Via The Endoscopic Endonasal Approach To The Lower Clivus
Authors: Hu Changchen , Zhou Liyuan , Ji Hongming , Zhang Gangli , Chen Shengli , Zhao Jianwei , Zhang Shiyuan , Liu Jiangtao , Wang Kaixuan , Li Pengfei , Li Ming , Zhao Yu , Li Hang 
Published: September 2021

Abstract
Background: The hypoglossal canal (HGC) is the most important structural landmark for the endoscopic endonasal approach to access the lower clivus (LC). We explored the feasibility of using the tough fibrous tissue covering the supracondylar groove (SCG) as a useful landmark to identify the location of the HGC. Methods: Four cadaveric specimens were dissected and analyzed. The craniovertebral junction (CVJ) region was accessed utilizing 4-mm endoscope with either 0° or 30° lenses. CVJ exposure and the surgical corridor areas were measured. The relationship between the tough fibrous tissue covering the SCG and the HGC was analyzed.Results: Tough fibrous connective tissue was tightly attached the SCG and ran superomedially to inferolaterally. The angle between the horizontal plane and the long axis of the SCG was 30°. Separating the tough tissue inferolaterally, we could locate the external orifice (EO) of the HGC to further accurately isolate the hypoglossal nerve. Conclusion: The tough fibrous connective tissue covered the SCG to the upper part of the HGC EO. The course of the tough fibrous connective tissue was superomedial to inferolateral. Using the tough fibrous connective tissue covering the SCG as a landmark, it was possible to accurately locate the HGC EO via the endoscopic endonasal approach to access the LC.
How do General Practitioners Handle Complexities? A Team Ethnographic Study in Japan
Authors: Haruta Junji , Goto Ryohei , Sachiko Ozone , Kimura Shuhei , Teruyama Junko , Hama Yusuke , Maeno Tetsuhiro 
Published: September 2021

Abstract
BackgroundGeneral practitioners (GPs) commonly deal with complexities, such as patients with socio-economic-medical problems. However, the methods they use to approach these complexities are still not understood. We speculated that elucidating these methods in terms of complex adaptive systems (CAS) to comprehensively assess GPs’ daily activities would contribute to improving the professional development of GPs. This study aimed to clarify the approaches adopted by GPs in Japan to handle complexities in their daily activities and examine them in terms of CAS extracted from GPs and other healthcare professionals.MethodsWe adopted interdisciplinary team-ethnographic research. Five hospitals and four clinics in Japan, selected by purposive sampling based on the presence of expert GPs. 62 individuals of various backgrounds working in five hospitals and four clinics were interviewed. Using field notes and interview data, the researchers iteratively discussed the adequacy of our interpretations. The first author (JH) prepared a draft report, which was reviewed by the GPs at the participating facilities. Through critical and iterative consideration of the different insights obtained, the final findings emerged together with representative data.ResultsWe identified four approaches used by GPs to deal with complexities. First, GPs treat patients with complex problems as a whole being and address their problems multi-directionally. Second, GPs build horizontal, trusting relationships with other healthcare professionals and stakeholders, and thereby reduce the degree of complexity of problems. Third, GPs change the learning climate while committing to their own growth based on societal needs and by acting as role models for other professionals through daily interpersonal facilitation. Fourth, GPs share community values with multi-professionals and thereby act as a driving force for organizational change. These various interactions among GPs, healthcare professionals, organizations and communities resulted in systematization of the healthcare and welfare network in their community. ConclusionsExpert GPs developed interconnected multidimensional systems in their community health and welfare networks to adapt to fluctuating social realities using four approaches. GPs’ work environment may be considered as a complex adaptive system (CAS) and the approach of GPs to complexities is CAS-based. Our findings are expected to have practical applications for GPs.
Urban Matanuska Flood Prediction using Deep Learning with Sentinel-2 Images
Authors: Chellapa Ramasamy Sankar Ram , Rajan Santhana Krishnan , Eanoch Golden Julie , Yesudhas Harold Robinson , Kumaragurubaran Lakshminarayanan , Long Hoang Viet , Kumar Raghvendra 
Published: September 2021

Abstract
In this paper, we produce a novel raster dataset depending upon the Sentinel-2 satellite. They envelop over thirteen spectral bands. Our novel data set consists of ten classes within a total of 27000 Geo-referenced and labelled images. Gradient Boosting Model (GBM) used to explore this novel dataset in which the overall prediction and accuracy of 97% is obtained from the support of Graphics Processing Unit (GPU) afforded from Google Colaboratory (Colab). The obtained classification result can provide a gateway for numerous earth observation applications. Here, in this paper, we also elaborate on how this classification model might be applied for a conspicuous change in land cover and how it plays an important role in improving the graphical maps.
Bibliometric Analysis and Visualization Harm Reduction in Indonesia Indexed in Scopus
Authors: Subandi Yeyen , Nurmandi Achmad , Qodir Zuly , Jubba Hasse , Purwaningsih Titin , Rochimah Tri Hastuti Nur 
Published: September 2021

Abstract
Background: Harm Reduction is a program to reduce the harm of narcotics for injecting drug users. The Harm Reduction (HR) program in Indonesia was initiated in 1999 with assistance and financial support from international donor agencies that lead to policy or program implementation. 9 components of Harm Reduction are still being implemented in Indonesia. The current study was conducted to analyze the bibliometric characteristics and trends of articles on Harm Reduction in Indonesia. Methods: This study uses VOSviewer affiliate analysis to visualize and analyze trends in the form of bibliometric maps. VOSviewer can also create publication maps, country maps, or journal maps based on shared citation networks or create keyword maps based on their networks. All data is taken from the Scopus database.Results: Articles from 1999 to 2021 in 41 journals indexed by Scopus with a total of 67 documents. Research on Harm Reduction in Indonesia in the last five years has only one significant increase, namely in 2019 with 10 article documents. This shows that international publications of research on Harm Reduction in Indonesia are not yet developed and there are not many interested people. Conclusions: There are still not many researches on Harm Reduction in Indonesia, besides that the results show that research sources on Harm Reduction in Indonesia are still widely available and accessible for further research in the future.
A Rare Case of IgG4-related Disease Manifesting as an Ulcerated Gastric Cancer Complicated With Gastric Mucormycosis
Authors: Zhan Yuting , Yang Yang , Zheng Hongmei , Zhang Yuting , Gu Li , Chen Dongliang , Fan Songqing 
Published: September 2021

Abstract
BackgroundIgG4-related disease (IgG4-RD) is a novel clinical entity that mimics many malignant, infectious, and inflammatory disorders. Many organs or tissues are now known to be involved in IgG4-RD; however, there has been no report about IgG4-RD of stomach with fungal infection. Case presentationWe reported a 56-year-old male with IgG4-RD manifesting as ulcerated gastric cancer complicated with gastric mucormycosis. Both clinical and imaging manifestations were atypical, in clinical, it was highly suspected that the disease is a malignant tumor as ulcerated gastric cancer. However, no pathological evidence of malignancy could be found in repeated biopsies and surgically excised gastric specimen. Histological examination showed ulcer and inflammatory granulation with lymphocytes and plasma cells in sheets, inflammation of vascular wall, formation of new fibrous tissue and inflammatory necrosis with hyphae and spores. The plasma cells had immunohistochemically strong staining for CD38, CD138, kappa, lambda, IgG and IgG4. And notably, IgG4/IgG positive plasma cell ratio was more than 40%, kappa/lambda positive staining ratio was approximately 1:1. Gastric mucormycosis was diagnosed with hyphae and spores confirmed by Gomori's methenamine silver staining and immunofluorescence and confocal laser-scanning microscopy. IgG4-RD manifesting as ulcerated gastric cancer complicated with gastric mucormycosis was diagnosed by multidisciplinary team discussion from gastroenterology, radiology and pathology department. The patient vomited blood three times for the following month. An emergent exploratory laparotomy was conducted, and a mass with 10×9×8cm adhered closely to adjacent organs could be touched in lesser curvature of gastric antrum. Anastomotic leakage occurred after the surgery, symptomatic treatments (negative pressure drainage and antibiotics) were applied without steroids and anti-fungus drugs. The patient gradually recovered and was advised to consult gastroenterology department for further steroids and anti-fungus drugs treatment. Conclusions﻿To our knowledge, it is the first report about IgG4-related disease manifesting a gastric ulcer with mucormycosis infection.
Magnetic Resonance Imaging Findings Among Young Adults with Low Back Pain at Nsambya Hospital
Authors: Lukecha Komakech Richard , Geoffrey Erem , Gonzaga Mubuuke A. , Sam Bugeza 
Published: September 2021

Abstract
Back ground: Studies on MRI findings among patients with LBP have been conducted; especially among adolescents and young adult population in developed countries. However, MRI lumber spine evaluation findings in young adult patients with low back pain in Uganda is not known. The purpose of this study was to determine the MRI findings and their correlation to clinical features in young adult patients with low back pain in Nsambya hospitalMethods: This was a descriptive cross sectional study. One hundred and fifty-seven patients with low back pain in the 18 - 39year age group underwent MRI lumbar spine evaluation. The MRI changes in the lumbar spine and correlation to clinical features were determined. Correlation was assessed by Pearson chi square tests (Fisher’s exact test) and p-values reported at 0.05 level of significance. Results: Of the 157 patients 129 (82.2%) had severe pain, whereas ninety (57.3%) had pain that had lasted more than 10 weeks. Sixty-five (41.4%) patients were found to have MRI evidence of disc desiccation, majority (61%) of whom had multiple level disease, mostly involving the lowest 2 disc levels. Facet joint arthropathy (47.8%), marginal osteophyte (31.8%) and disc contour irregularity [disc bulge] (31.2%) were other common MRI features seen. There was an association between duration of pain and limb weakness, and development of marginal osteophytes. There was also association between clinical presentation and disc bulge. Conclusions: The MRI finding of disc degeneration among young adult patients with LBP is higher than reported. Age and pain distribution are predictors of developing disc desiccation.
Mutation of KIT In Cellular Extraskeletal Myxoid Chondrosarcoma: A Case of And Literature Review
Authors: Wang Chen , You Zhijie , Chen Xiao-Yan , Lin Jie , Wu Yi-Juan 
Published: September 2021

Abstract
Background: Extraskeletal myxoid chondrosarcomas (EMCs) have been recognised as genetically and biologically solid tumours. Only a few studies have discussed the role of CD117 in immunohistochemical(IHC) staining or the influence of the KIT gene in EMC. We herein present a novel case of cellular EMC exhibiting EWSR1-NR4A3 fusion, KIT exon 13 mutations and a strong diffuse expression of CD117.Case presentation: A man presented with a fist-sized tumour on his left shoulder. Computed tomography(CT) revealed a tumour in the left thoracic and dorsal muscle space. The tumour was completely resected. Histologically, the tumour cells had a nodular structure and underwent infiltrative growth, with the invasion of the peripheral fat and muscle tissues. The tumour cells had uniform size, round nuclei with well-defined nucleoli and eosinophilic cytoplasm. Immunohistochemically, the tumour cells were positive for CD117, vimentin, CD56 and NSE and revealed focal expression for desmin, with negativity for myogenin, S-100, SYN, INSM1, CD34, STAT6, INI-1, Brachyury, ERG, TLE1, AE1/AE3, WT-1, CD99 and SMA. Next-generation sequencing revealed EWSR1-NR4A3 fusion and KIT exon 13 mutations. The patient had no further treatment after surgery, and no recurrence or metastasis in follow-up for nearly 2 months.Conclusions: Molecular detection is an indispensable technique for the diagnosis of EMC, especially rare variants like cellular EMC. The KIT mutations noted in this case report may offer fresh insights regarding EMC treatment.
Self-assembled network polymer electrolyte membranes for application in fuel cells at 250℃
Authors: Lee Seungju , Jo YoungSuk , Hwang Son-Jong , Park Yongha , Kim Yeong Cheon , Lee Tae Kyung , Kim Hyoung-Juhn , Nam Suk Woo , Lee So Young 
Published: September 2021

Abstract
Modern H2-based energy storage and conversion devices require a polymer electrolyte membrane (PEM) fuel cell–based integrated power system with synergistic heat integration. The key issue in integrated power systems is developing a PEM that can operate at 200–300 °C. However, currently used phosphoric-acid-based high-temperature PEM fuel cells limited stability at higher operating temperatures. Herein, we introduce a cerium hydrogen phosphate (CeHP) PEM that conducts protons above 200 °C through a self-assembled network (SAN). The SAN-CeHP-PBI reached maximum power densities of 2.4 W cm-2 and operate stably for over 7000 minute without any voltage decay at 250 ℃ under H2/O2 and anhydrous conditions. The developed fuel cell can be combined with an external hydrogen generator that uses a liquid hydrogen carrier such as N-ethylcarbazole and methanol as fuel, thus achieving a high energy efficiency. The thermal stability and fuel flexibility of these SAN-CeHP-PBI demonstrate potential for commercial applications.
Carcinoma of Unknown Primary Origin: Application of Immunohistochemistry
Authors: Mokhtari Maral , Safavi Dornaz , soleimani Neda , Monabati Ahmad , Safaei Akbar 
Published: September 2021

Abstract
Background: The primary origin of some carcinomas may be obscured to the clinicians but it is crucial to identify the origin of these carcinomas because it affects the prognosis and treatment, especially for the novel targeted therapies. Immunohistochemistry (IHC) may be useful for determination of the primary origins. In this study, we conducted a retrospective survey to evaluate the frequency and accuracy of each IHC marker used to identify the origin of these carcinomas.Method: Archival review of pathology department revealed 307 cases of carcinoma of known primary origin(CUP) between 2015 and 2020 who were available. Demographic information, site of biopsy, clinical and pathologic diagnosis, and IHC results were collected.Results: The cases consisted of 157 (51.15%) male and 150 (48.85%) female patients. The patients age range was 14-92 years and 106 cases (34.5%) were dead. In 27% of cases, the primary origin remained still unknown. The pathological and clinical diagnostic agreement was 59%. CK7+/CK20- pattern of expression was the most common pattern in CUPs(55.3%) followed by CK7-/CK20- (19%), CK7+/CK20+(15%), CK7-/CK20+(10.7%), respectively.Conclusion: IHC study may aid in the diagnosis of CUP. However, some cases will still remain unknown origin after IHC study, so more diagnostic methods or gene expression studies may be needed for definite diagnosis.
Serum Levels of IL-12, IL-6, IL-10, IL-17 and IFN-γ in Female Students with Vitamin D Deficiency
Authors: Asadikaram Gholamreza , Jamali Zahra , Igder Somayeh , Nabati Saeedeh , Bagheri Vahid , Karimabad Mojgan Noroozi , Khaksari Mohammad , Arababadi Mohammad Kazemi 
Published: September 2021

Abstract
Background: Several studies demonstrated the regulatory effects of vitamin D3 on the immune system. The aim of this study was to investigate the serum levels of IL-12, IL-6, IL-10, IL-17 and IFN-g cytokines in 11-17 year-old female students with 25-hydroxyvitamin D3 (25-(OH) D3) (VitD3) deficiency. Methods: 100 subjects with VitD3 deficiency were selected as the case group and an equal number of individuals with sufficient levels of VitD3 were selected as a control group. The serum levels of IL-10, IL-6, IL-12, IFN-g and IL-17 were measured by ELISA method. Results: The results showed that the serum concentrations of IL-12 (P= 0.005) and IFN-g (P= 0.019) were significantly lower in VitD3-deficient group compared to control group. There were no significant differences in serum levels of IL-6 (P= 0.66), IL-10 (P= 0.647) and IL-17 (P= 0.159) between cases and controls.Conclusion: These results suggest that VitD3deficiency may result in decreased inflammatory cytokines production, which are required for proper immune functions. However, the effects of VitD3 on IL-6 and IL-17A, as the pro-inflammatory and IL-10, as anti-inflammatory cytokines needs more investigations.
Misdiagnosis of Systemic Metastatic Melanoma for fungal infection: A case report
Authors: Sun Juan , Zhu Yun-Zhu , Shao Pan-Pan , Ke Jing , Wang Wei , Sun Qiu-Lin , Li Jia-Bin , Cheng Jun 
Published: September 2021

Abstract
BackgroundMost of malignant melanomas originate from skin and often metastasize to the lungs, rarely metastasizes to the liver and bone. However, imageology characters of lung metastasis tumor are commonly similar to those of fungal infections. Case presentationA patient was admitted with unhealed plantar puncture wound for 3 years, and cough and expectoration for 2 years. The chest computed tomography (CT) revealed multiple nodules with cavities, and the patient was diagnosed of pulmonary fungal infection in another hospital and received antifungal therapy for more than 8 months, but the clinical symptoms and chest imaging findings continue to progress. After admission, the pathological results of both lung biopsy and biopsy of the plantar wound 3 years ago indicated malignant melanoma. ConclusionsThe diagnosis of lung lesions cannot rely solely on imaging diagnosis, lung biopsy should be performed if necessary.
Facile Synthesis of Metal Doped Graphite Carbon Nitride for Photocatalytic Degradation of Tetracycline Under Visible Light Irradiation
Authors: zhao yin , qin hong , luo Qianlan , wang ziwei , wang han , wang zixuan , he yangzhuo , Tian Quyang , Wang Changlin , Xu Piao 
Published: September 2021

Abstract
Using semiconductor photocatalysts for antibiotic contaminants degradation under visible light has become a hot topic in recent years. Herein, a novel cadmium doped graphite phase carbon nitride (Cd/g-C3N4) photocatalyst was successfully constructed via 60 °C oil bath method to degrade tetracycline. Experimental and characterization results revealed that cadmium was well doped at g-C3N4 surface and exhibited high intercontact with g-C3N4. Meanwhile, Cd/g-C3N4 presented excellent electrical conductivity and inhibited the recombination of electron-hole pairs. The introduction of cadmium significantly improved the photocatalytic activity and the degradation efficiency of 10 Cd/g-C3N4 reached to 89.09%, which was exceeded 2.0 times than pure g-C3N4 (43.99%). Additionally, the quenching experiments and electron spin-resonance tests exhibited holes (h+), hydroxyl radicals (•OH) and superoxide radicals (•O2−) were dominated active species in TC degradation. Furthermore, the effects of various conditions on the reaction process, such as different pH, initial TC concentrations and catalyst dosage, were also researched. This work gives a reasonable point to synthesize high-efficiency and economic photocatalysts.
Adjuvanticity of sliver nanoparticles with Infectious bursal disease virus VP2 protein and its effect on humoral immune response in chickens
Authors: Awandkar Sudhakar P. , Tembhurne Prabhakar A , Kurkure Nitin V , Chaudhari Sandeep P , Bonde Sachin W , Ingle Vijay C 
Published: September 2021

Abstract
The present study was conducted to decipher the effect of silver nanoparticles conjugated marker recombinant VP2 immunogen of Infectious bursal disease virus on humoral immune response in chickens. The hypervariable VP2 gene segment of field Infectious bursal disease virus, consisting of major and minor hydrophilic loops, was amplified using reverse transcription-polymerase chain reaction. The gene segment of size 664 bp was cloned into pGEM-T Easy plasmid followed by subcloning into pET32a plasmid vector. Truncated recombinant VP2 protein (rVP2, 19 kDa) was expressed in a prokaryotic expression system using Escherichia coli BL32DE3 cells. The rVP2 protein showed reactivity with specific anti VP2 chicken antibodies. The results of Western blot revealed its utility in serological diagnosis. The recombinant antigen was tested for immunogenic potential by vaccinating the chickens with and without silver nanoparticles. The rVP2 protein blended with adjuvant grade montanide oil showed a highly significant rise in serum IgY titers. The titers induced by rVP2 protein mixed with montanide oil were non-significant when compared with titers induced by the conventional vaccines. The IgY response was highly significant in chickens vaccinated with rVP2 protein blended with montanide oil and silver nanoparticles than in chickens vaccinated with conventional vaccines or rVP2 protein. The results represent Infectious bursal disease virus rVP2 protein as a promising candidate for the DIVA vaccine and sero-diagnostic tool. For the first time, the current study elucidated the adjuvanticity effect of silver nanoparticles on avian Infectious bursal disease virus rVP2 vaccine potency.