bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPLEMENTASI PERATURAN BUPATI BOGOR NOMOR 60 TAHUN 2020 DI LINGKUNGAN KELURAHAN PADASUKA
Authors: Achsan Robbi , Al-Afghani M. Mova , Mustika Desty Anggie 
Published: May 2021

<p class="22aIsiParagraf"><em>In preventing the spread of the coronavirus, the Bogor Regency Government as the object of analysis carried out by this author has re-issued a new regulation, namely the Bogor Regent Regulation Number 60 of 2020. In addition to the implementation of this new regulation through the author's eyes, it turns out that some people still do not heed this new regulation. by not wearing a mask when traveling, not washing hands, and not maintaining distance or avoiding crowds. Especially in the Padasuka Urban Village which is the object of analysis in Bogor Regency, there are still many RT / RW areas that do not provide a place to wash hands, put up an appealing banner or wear a mask and keep a distance from the crowd.</em></p><p class="22aIsiParagraf"> </p><p class="16aJudulAbstrak"><strong>Abstrak</strong></p><p class="16cKataKunci">Dalam melakukan pencegahan penyebaran virus corona ini Pemerintah Kabupaten Bogor sebagai objek analisis yang dilakukan oleh penulis ini kembali menerbitkan Peraturan baru yaitu Peraturan Bupati Bogor Nomor 60 Tahun 2020. Disamping penerapan peraturan baru ini melalu kacamata pengamatan penulis ternyata masih saja sebagian masyarakat tidak mengindahkan peraturan baru ini dengan tidak memakai masker pada saat bepergian, tidak mencuci tangan dan tidak menjaga jarak atau menghindari kerumunan. Terkhusus dilingkungan Kelurahan Padasuka yang menjadi objek analisis di Kabupatn Bogor, masih banyak ditemui beberapa wilayah RT/RW yang tidak menyediakan tempat untuk mencuci tangan, memasang spanduk himbauan atau memakai masker dan menjaga jarak dari kerumunan.</p>
THE ANALYSIS OF NOUN DERIVED FROM ADJECTIVE FOUND IN BARACK OBAMA’S SPEECH AND THE TEACHING OF GRAMMAR
Authors: Tampangella Terra , Rokhayati Titi 
Published: May 2021

The study is qualitative research. This research deals with noun derived from adjective found in Barack Obama’s speech. The objectives of the research are to find out the position of the noun derived from adjectives in the sentence pattern found in Barack Obama’s speech and to describe the application of noun derived from adjective to teach grammar. In collecting the data, the researchers read the script, identified noun derived from adjectives, analysed the data related to the theory of noun derived from the adjective, analyzing the data quantitatively and qualitatively, applied the finding to teach the grammar at eleventh grade student of Senior High School. The result shows that there are three positions of the noun derived from adjectives based on sentence pattern. They are 30 SVO (Subject + Verb + Object) (50%), 18 SVA ( Subject + Verb + Adverb ) (30%), 12 SVC ( Subject + Verb + Complement ) (20%). The teacher could apply in pre teaching by giving description of Barrack Obama’s characters, whilst teaching by giving the explanation about part of speech and post teaching by strengthening the use of noun derived from adjective as one of part of speech in which it becomes the most important piece in a sentence.
Educação em saúde na Atenção Primária no ciclo gravídico puerperal: Uma revisão integrativa
Authors: Cavalcanti Leticia Miná de Britto , Sousa Milena Nunes Alves de 
Published: May 2021

Introdução: A gestação e puerpério apresentam inúmeras transformações na vida da mulher. Nesse sentido, ações de educação em saúde são fundamentais para a prevenção de agravos, doenças e complicações. Objetivo: Analisar as ações de educação em saúde desenvolvidas na atenção primária para a prevenção de agravos e melhoria da qualidade de vida no ciclo gravídico puerperal. Método: Revisão integrativa da literatura a partir da biblioteca Scientific Electronic Library Online e base de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde, Base de Dados de Enfermagem e U. S. National Library of Medicine, de 2016 a 2021. Utilizaram-se os seguintes Descritores em Ciências da Saúde e suas combinações nas línguas portuguesa e inglesa: “educação em saúde” AND “atenção primária” AND “gestantes”; “health education” and “primary care” and “pregnancy”. A amostra final constituiu-se de 20 artigos. Resultados: Verificou-se que o período de maior abordagem foi no período de gestação contemplando 75% dos artigos. Por fim, 75% dos artigos estudados dizem respeito a práticas educativas, das quais a de maior destaque foi o diálogo, com 25%. Entretanto, também se destacaram as oficinas educativas com 20%. Conclusão: É notória a importância da abordagem da educação em saúde na atenção primária para qualificação da saúde da gestante e puérpera atribuída à prevenção de agravos, doenças e complicações nesse período. Sendo assim, destaca-se a necessidade de continuidade, intensificação e ampliação das estratégias educativas em saúde desenvolvidas na atenção primária como instrumento fundamental no ciclo gravídico puerperal.
Percepção das gestantes adolescentes sobre as consultas de pré-natal em um hospital escola
Authors: Oliveira Marcela Claudia de Paula , Trindade Fátima Maria França , Diniz Cinthia Martins Menino , Lima Kélita Mirelle Oliveira , Lettieri Maria Glecia Saraiva , Almeida Tássia Daniele Lima 
Published: May 2021

Teve como objetivo identificar a percepção das gestantes adolescentes sobre as consultas de pré-natal em um hospital escola. Estudo descritivo, exploratório, com abordagem qualitativa, realizado no ambulatório de pré-natal de um Hospital Universitário na Cidade do Recife-PE, e aprovado pelo Comitê e Ética e Pesquisa do local de estudo. Foram incluídas gestantes com idade entre 10-19 anos, onde a Organização Mundial da Saúde circunscreve a adolescência à segunda década da vida (de 10 a 19 anos), com pelo menos três consultas de pré-natal e excluídas as que mesmo após todas as explicações, não compreenderam o objetivo da pesquisa. Participaram da pesquisa cinco gestantes do pré-natal médico, com idades entre 12 e 19 anos. A maioria eram solteiras (n=05), cinco ainda estudam, uma possuía ensino médio completo e outra o ensino fundamental. 04 moram em Recife e todas residem em área urbana. A maioria (n=05) se considera da cor parda, 05 possuíam renda familiar até um salário mínimo, duas mais que um salário e nenhuma trabalhava. Do processo de análise do discurso das participantes emergiram dois eixos temáticos: atendimento nas consultas de pré-natal: visão das gestantes e educação em saúde nas consultas de pré-natal. O presente estudo possibilitou conhecer como ocorrem as consultas médicas de pré-natal e como as gestantes adolescentes percebem a educação em saúde.
Identification of Key Genes With Differential Correlations in Lung Adenocarcinoma
Authors: Zhou You , Xu Bin , Zhou Yi , Liu Jian , Zheng Xiao , Liu Yingting , Deng Haifeng , Liu Ming , Ren Xiubao , Xia Jianchuan , Kong Xiangyin , Huang Tao , Jiang Jingting 
Published: May 2021

BackgroundWith the advent of large-scale molecular profiling, an increasing number of oncogenic drivers contributing to precise medicine and reshaping classification of lung adenocarcinoma (LUAD) have been identified. However, only a minority of patients archived improved outcome under current standard therapies because of the dynamic mutational spectrum, which required expanding susceptible gene libraries. Accumulating evidence has witnessed that understanding gene regulatory networks as well as their changing processes was helpful in identifying core genes which acted as master regulators during carcinogenesis. The present study aimed at identifying key genes with differential correlations between normal and tumor status.MethodsWeighted gene co-expression network analysis (WGCNA) was employed to build a gene interaction network using the expression profile of LUAD from The Cancer Genome Atlas (TCGA). R package DiffCorr was implemented for the identification of differential correlations between tumor and adjacent normal tissues. STRING and Cytoscape were used for the construction and visualization of biological networks.ResultsA total of 176 modules were detected in the network, among which yellow and medium orchid modules showed the most significant associations with LUAD. Then genes in these two modules were further chosen to evaluate their differential correlations. Finally, dozens of novel genes with opposite correlations including ATP13A4-AS1, HIGD1B, DAP3, and ISG20L2 were identified. Further biological and survival analyses highlighted their potential values in the diagnosis and treatment of LUAD. Moreover, real-time qPCR confirmed the expression patterns of ATP13A4-AS1, HIGD1B, DAP3, and ISG20L2 in LUAD tissues and cell lines.ConclusionOur study provided new insights into the gene regulatory mechanisms during transition from normal to tumor, pioneering a network-based algorithm in the application of tumor etiology.
Alterations of Gut Microbiota in Patients With Graves’ Disease
Authors: Chang Shih-Cheng , Lin Shu-Fu , Chen Szu-Tah , Chang Pi-Yueh , Yeh Yuan-Ming , Lo Fu-Sung , Lu Jang-Jih 
Published: May 2021

Graves’ disease (GD) is a systemic autoimmune disease characterized by hyperthyroidism. Evidence suggests that alterations to the gut microbiota may be involved in the development of autoimmune disorders. The aim of this study was to characterize the composition of gut microbiota in GD patients. Fecal samples were collected from 55 GD patients and 48 healthy controls. Using 16S rRNA gene amplification and sequencing, the overall bacterial richness and diversity were found to be similar between GD patients and healthy controls. However, principal coordinate analysis and partial least squares-discriminant analysis showed that the overall gut microbiota composition was significantly different (ANOSIM; p &lt; 0.001). The linear discriminant analysis effect size revealed that Firmicutes phylum decreased in GD patients, with a corresponding increase in Bacteroidetes phylum compared to healthy controls. In addition, the families Prevotellaceae, and Veillonellaceae and the genus Prevotella_9 were closely associated with GD patients, while the families Lachnospiraceae and Ruminococcaceae and the genera Faecalibacterium, Lachnospira, and Lachnospiraceae NK4A136 were associated with healthy controls. Metagenomic profiles analysis yielded 22 statistically significant bacterial taxa: 18 taxa were increased and 4 taxa were decreased. Key bacterial taxa with different abundances between the two groups were strongly correlated with GD-associated clinical parameters using Spearman’s correlation analysis. Importantly, the discriminant model based on predominant microbiota could effectively distinguish GD patients from healthy controls (AUC = 0.825). Thus, the gut microbiota composition between GD patients and healthy controls is significantly difference, indicating that gut microbiota may play a role in the pathogenesis of GD. Further studies are needed to fully elucidate the role of gut microbiota in the development of GD.
Real-Time In Situ Navigation System With Indocyanine Green Fluorescence for Sentinel Lymph Node Biopsy in Patients With Breast Cancer
Authors: Wang Zhaorui , Yang Xiaowei , Wang Jingjing , Liu Peng , Pan Yubo , Han Chunguang , Pei Jing 
Published: May 2021

BackgroundThe naked-eye invisibility of indocyanine green fluorescence limits the application of near-infrared fluorescence imaging (NIR) systems for real-time navigation during sentinel lymph node biopsy (SLNB) in patients with breast cancer undergoing surgery. This study aims to evaluate the effectiveness and safety of a novel NIR system in visualizing indocyanine green fluorescence images in the surgical field and the application value of combined methylene blue (MB) and the novel NIR system in SLNB.MethodsSixty patients with clinical node-negative breast cancer received indocyanine green (ICG) and MB as tracers. Two NIR system instruments, namely, lymphatic fluorescence imaging system (LFIS) designed by the University of Science and Technology of China and vascular imager by Langfang Mingde Medical Biotechnology Co., Ltd. (Langfang vascular imager), were used as navigation assistance to locate sentinel lymph nodes (SLNs). Excising the lymph nodes developed by both MB and ICG by two NIR systems or palpably suspicious as SLNs and undergoing rapid pathological examination.ResultsBoth instruments exhibited 95% (57/60) success for real-time lymphatic fluorescent images. A total of 186 SLNs were identified, of which two were pathologically confirmed as lacking any lymph node tissue. SLN identification rate was 100% (184/184) for MB plus LFIS and 86.96% (160/184) for MB alone. The median number of SLNs identified by LFIS combined with MB was 3 (range of 1–8), which was significantly higher than that by MB alone at 2 (range 1–7) (P&lt;0.05).ConclusionLFIS effectively detects SLNs in breast cancer, projects the fluorescence signals during surgery, and provides a continuous surgical navigation system without the need for a remote monitor. The ICG method navigated by combined LFIS and MB may be a promising alternative tracer for radioisotope in SLN mapping.Clinical Trial RegistrationThis clinical trial was registered with the China Clinical Trial Center, registration number ChiCTR2000039542.
Surgical and Peri-Operative Considerations for Brain Metastases
Authors: Gupta Saksham , Dawood Hassan , Giantini Larsen Alexandra , Fandino Luis , Knelson Erik H. , Smith Timothy R. , Lee Eudocia Q. , Aizer Ayal , Dunn Ian F. , Bi Wenya Linda 
Published: May 2021

IntroductionBrain metastases are the most common brain tumors in adults, whose management remains nuanced. Improved understanding of risk factors for surgical complications and mortality may guide treatment decisions.MethodsA nationwide, multicenter analysis was conducted with a retrospective cohort. Adult patients in the 2012-2015 American College of Surgeons National Surgical Quality Improvement Project (ACS NSQIP) databases who received a craniotomy for resection of brain metastasis were included.Results3500 cases were analyzed, of which 17% were considered frail and 24% were infratentorial. The most common 30-day medical complications were venous thromboembolism (3%, median time-to-event [TTE] 4.5 days), pneumonia (4%, median TTE 6 days), and urinary tract infections (2%, median TTE 5 days). Reoperation and unplanned readmission occurred in 5% and 12% of patients, respectively. Infratentorial approach and frailty were associated with reoperation before discharge (OR 2.0 for both; p=0.01 and p=0.03 respectively), but not after discharge. Infratentorial approaches conferred heightened risk for readmission for hydrocephalus (OR 5.1, p=0.02) and reoperation for cerebrospinal fluid diversion (OR 7.1, p&lt;0.001).Overall 30-day mortality was 4%, with nearly three-quarters occurring after discharge. Pre-frailty and frailty were associated with increased odds for post-discharge mortality (OR 1.7 and 2.7, p&lt;0.05), but not pre-discharge mortality. We developed a model to identify pre-/peri-operative variables associated with death, including frailty, thrombocytopenia, and high American Society of Anesthesiologists score (AUROC 0.75).ConclusionsOptimization of metrics contributing to patient frailty and heightened surveillance in patients with infratentorial metastases may be considered in the peri-operative period.
miRNA-Based Therapeutics in Breast Cancer: A Systematic Review
Authors: Grimaldi Anna Maria , Salvatore Marco , Incoronato Mariarosaria 
Published: May 2021

BackgroundBreast cancer (BC) is the most common cancer in females and despite advances in treatment, it represents the leading cause of cancer mortality in women worldwide. Conventional therapeutic modalities have significantly improved the management of BC patients, but subtype heterogeneity, drug resistance, and tumor relapse remain the major factors to hamper the effectiveness of therapy for BC. In this scenario, miRNA(miR)-based therapeutics offer a very attractive area of study. However, the use of miR-based therapeutics for BC treatment still represents an underdeveloped topic. Therefore, this systematic review aims at summarizing current knowledge on promising miR-based therapeutics for BC exploring original articles focusing on in vivo experiments.MethodsThe current systematic review was performed according to PRISMA guidelines. PubMed and EMBASE databases were comprehensively explored to perform the article search.ResultsTwenty-one eligible studies were included and analyzed: twelve focused on antitumor miR-based therapeutics and nine on metastatic miR-based therapeutics. We found 18 different miRs tested as potential therapeutic molecules in animal model experiments. About 90% of the selected studies evaluate the efficiency and the safety of miRs as therapeutic agents in triple-negative (TN)-BC mouse models. Among all founded miR-based therapeutics, miR-21 emerged to be the most investigated and proposed as a potential antitumoral molecule for TNBC treatment. Besides, miR-34a and miR-205a appeared to be successful antitumoral and antimetastatic molecules.ConclusionsOur analysis provides a snapshot of the current scenario regarding the miRs as therapeutic molecules in BC. Nevertheless, despite many efforts, none of the selected studies goes beyond preclinical studies, and their translatability in the clinical practice seems quite premature.
Repurposing Kinase Inhibitor Bay 11-7085 to Combat Staphylococcus aureus and Candida albicans Biofilms
Authors: Escobar Iliana E. , Possamai Rossatto Fernanda Cristina , Kim Soo Min , Kang Min Hee , Kim Wooseong , Mylonakis Eleftherios 
Published: May 2021

Staphylococcus aureus and Candida spp. are commonly linked with topical biofilm-associated infections such as those found on chronic wounds. These biofilms are notoriously difficult to treat, highlighting the grave need to discover and study new broad-spectrum agents to combat associated infections. Here we report that the kinase inhibitor Bay 11-7085 exhibited bactericidal activity against multidrug-resistant S. aureus with a minimum inhibitory concentration (MIC) of 4 μg/ml. In addition, S. aureus strain MW2 did not acquire resistance to antibiotic pressure. Furthermore, Bay 11-7085 exhibited potency against Candida albicans and the emerging pathogen Candida auris with a MIC of 0.5–1 μg/ml. Bay 11-7085 partially inhibited and eradicated biofilm formation of various pathogens, such as VRSA (vancomycin-resistant S. aureus), as well as antifungal-resistant Candida spp. isolates. Notably, Bay 11-7085 partially inhibited initial cell attachment and formation of a VRSA-C. albicans polymicrobial biofilm in vitro. In contrast to C. albicans, inhibition of VRSA biofilm was linked to initial cell attachment independent of its bactericidal activity. Finally, Bay 11-7085 was effective in vivo at increasing the lifespan of C. elegans during an S. aureus and a C. albicans infection. Our work proposes kinase inhibitor Bay 11-7085 as a potential compound capable of combating biofilms associated with primary multidrug-resistant bacteria and yeast pathogens associated with wound infections.
What Is the Best Discipline to Predict Overall Triathlon Performance? An Analysis of Sprint, Olympic, Ironman® 70.3, and Ironman® 140.6
Authors: Sousa Caio Victor , Aguiar Samuel , Olher Rafael Reis , Cunha Rafael , Nikolaidis Pantelis Theodoros , Villiger Elias , Rosemann Thomas , Knechtle Beat 
Published: May 2021

Objective: To analyze the proportion of dedication in each triathlon discipline (swimming, cycling, and running) and the importance of each separate discipline to predict overall performance of elite triathletes across different triathlon distances.Methods: Data from 2015 to 2020 (n = 16,667) from official races and athletes in Sprint, Olympic distance, IM 70.3 (Half-Ironman distance), and IM 140.6 (Full-Ironman distance) competitions were included. The proportion of each discipline was calculated individually and compared using general linear models by event distance, sex, and performance level. Automatic linear regression models were applied for each distance considering overall performance as the dependent variable.Results: A within-distance analysis showed that the best predictor for Sprint is cycling, for Olympic is swimming, for IM 70.3 is cycling, and for IM 140.6 is running. A between-distance analysis revealed that swimming is a better predictor in Olympic distance than in other triathlon distances. Cycling is a poor predictor for overall performance in IM 140.6, and the importance of running to predict overall performance is the highest in IM 140.6 and diminishes with decreasing race distance.Conclusion: Each discipline represents a different relative portion and importance to predict overall performance depending on the triathlon distance. Swimming is the most important predictor discipline in Sprint- and Olympic-distance triathlon, cycling in IM 70.3, and running in IM 140.6.
CAMPUR DAN ALIH KODE PADA POLA KOMUNIKASI ANTAR DOSEN DAN MAHASISWA DI LNGKUNGAN UNIKOM DALAM APLIKASI MEDIA SOSIAL - KAJIAN SOSIOLINGUISTIK
Authors: Prihandini Asih , Bustam M Rayhan , Heriyati Nungki 
Published: May 2021

Penelitian yang berjudul “Campur dan Alih Kode pada Pola Komunikasi antar Dosen dan Mahasiswa di Lingkungan UNIKOM dalam Aplikasi Media Sosial: Kajian Sosiolinguistik” ini merupakan sebuah penelitian lanjutan dari penelitian yang telah dilakukan sebelumnya yang berjudul: “Alih Kode dan Campur Kode pada Pola Komunikasi Dosen UNIKOM di Aplikasi Kuliah Online Unikom: Kajian Sosiolinguistik”. Penelitian ini bertujuan untuk mendeskripsikan jenis dan bentuk alih dan campur kode pada pola komunikasi antar dosen dan mahasiswa UNIKOM dalam aplikasi media sosial, dan faktor yang mempengaruhinya, serta dampak yang ditimbulkan oleh pola komunikasi tersebut. Adapun yang menjadi subjek penelitian ini adalah kode atau bahasa yang digunakan oleh dosen-dosen dan mahasiswa UNIKOM di aplikasi media sosial, sedangkan objeknya adalah campur dan alih kode pada ujaran yang diungkapkan dosen-dosen dan mahasiswa tersebut.
Teknik pengumpulan data yang digunakan pada penelitian ini adalah purposive sampling; yakni mengumpulkan sampel data yang berisikan kasus-kasus alih kode dan campur kode dengan tujuan untuk mengetahui karakteristik jenis, bentuk, faktor, dan dampak pemakaian alih kode dan campur kode. Data yang dikumpulkan, kemudian dipilah berdasarkan kasus-kasus alih kode dan campur kode yang terdapat di dalamnya, lalu, dianalisis dengan teknik analisis deskriptif sesuai dengan konteksnya.
Penelitian ini diharapkan dapat memberikan kontribusi pemahaman tentang campur kode dan alih kode, terutama dalam mendeskripsikan jenis, faktor, dan dampaknya dalam kegiatan berbahasa sehari-hari, Adapun tujuan jangka panjang, diharapkan penelitian ini dapat memberikan pencerahan tentang pola komunikasi yang efektif, terutama terhadap komunikasi antara dosen dan mahasiswa sebagai masyarakat akademis yang terkadang memerlukan penyesuaian pola dan cara berbahasa tertentu.
Selain itu, penelitian ini mempunyai target khusus yakni diharapkan dapat digunakan sebagai salah satu bahan pembelajaran kepada dosen dan mahasiswa ketika melakukan kegiatan belajar mengajar mengenai berbahasa, misalnya yang berhubungan dengan percakapan atau dialog, serta penggunaannya dalam masyarakat berdasarkan bentuk dan fungsi yang sesuai.

Keywords : alih kode, campur kode, media sosial