bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anterior segment reconstruction with artificial iris and Descemet membrane endothelial keratoplasty: a staged surgical approach
Authors: Ang Marcus , Tan Donald 
Published: February 2021

PurposeTo describe a surgical approach that involves anterior segment reconstruction with CustomFlex Artificial Iris (CAI; HumanOptics, Erlangen, Germany) followed by Descemet membrane endothelial keratoplasty (DMEK) in complex eyes with corneal decompensation.MethodsRestrospective case series of eyes that underwent anterior segment restoration involving (1) synechiolysis of peripheral anterior synechiae and excision of iris remnants, (2) securing a well-fixated posterior chamber intraocular lens and (3) suture-fixated or capsular bag placement of CAI. All eyes then underwent DMEK using a pull-through technique with the DMEK EndoGlide (Network Medical Products, Ripon, UK). Main outcomes were successful anterior segment restoration and corneal clarity with central corneal thickness (CCT).ResultsFive eyes of five patients (median age 61 years, range 27–69 years; 60% female) underwent anterior segment reconstruction with CAI implantation (4 suture-fixated), followed by successful DMEK surgery (median 2 months later, range 1–5 months). There were no major intraoperative complications or primary graft failure, with one peripheral graft detachment that underwent a successful re-bubble at 1 week. All eyes had stable CAI implants and DMEK grafts remained clear at last follow-up with reduction in mean central corneal thickness (preoperative: 658±86 µm vs postoperative: 470±33 µm, p=0.005).ConclusionThis pilot study highlights a feasible approach of initial anterior segment reconstruction with CAI implantation, prior to DMEK, in eyes with significant anterior segment abnormalities such as iris damage or extensive peripheral anterior synechiae and corneal decompensation.
Trends in healthcare utilisation for firearm-related injuries among a cohort of publicly insured children in Ohio
Authors: Gowda Charitha , Hardy Rose Y , Traylor Steven , Liu Gilbert C 
Published: February 2021

ObjectiveTo examine healthcare utilisation for all firearm-related injuries among publicly insured children.MethodsA retrospective analysis of firearm injury medical claims among paediatric (<21 years) Medicaid beneficiaries in Ohio from 2010 to 2018. Factors associated with unintentional and intentional firearm injury were explored using multivariable logistic regression. Average annual patient healthcare costs were determined in 2019 US$.ResultsThere were 1061 firearm injury-related claims (853 (80%) unintentional; 154 (15%) intentional; 54 (5%) unknown) occurring in 663 children over 2 736 517 available person-years. From 2010 to 2018, yearly total firearm claims rose from 19.7 to 31.3 per 100 000 persons (p=0.033). Urban children experienced a non-significant increase in firearm claims rate over time (26.1 vs 35.0/100 000; p=0.066) while the claims rate nearly tripled among those in rural areas (8.4 vs 24.0/100 000; p=0.012). Younger age, females and rural residence were associated with reduced odds of injury claims. The average annual costs for emergency department and inpatient visits, respectively, were $260 and $5735.ConclusionRisk and type of firearm injury claims among low-income children in Ohio varies by age, sex and residence. Prevention programmes should be tailored based on these demographics.
Survival of patients with asbestosis can be assessed by risk-predicting models
Authors: Keskitalo Eerika , Salonen Johanna , Vähänikkilä Hannu , Kaarteenaho Riitta 
Published: February 2021

ObjectivesOur aim was to investigate the pulmonary function test (PFT) results of patients with asbestosis and determine whether baseline PFTs and the risk-predicting models such as gender, age and physiologic (GAP) variables model and composite physiologic index (CPI) would be useful in predicting survival in these patients.MethodsDemographics and PFTs of 100 patients with asbestosis were evaluated. The survival difference between the GAP stages was determined with Kaplan-Meier survival curves with statistical significance analysed with log-rank test. The suitability of the risk-predicting models and baseline PFTs to predict the survival of patients was analysed with Cox regression.ResultsAt baseline, the mean value of diffusion capacity for carbon monoxide (DLCO) was 65%; for forced vital capacity it was 81%, with restrictive lung function being the most common impairment. The median estimated survival of the patients was 124 months, that is, 171 months in GAP stage I, 50 months in stage II and 21 months in stage III (p<0.001). CPI, DLCO% predicted, age at baseline and GAP stage were significant predictors of mortality (all p values under 0.001).ConclusionsGAP and CPI as well as baseline DLCO% predicted were significant parameters in the evaluation of the prognosis of the patients with asbestosis; they may be useful in clinical practice when considering treatment strategies of individual patients.
The origin of the proton radius puzzle
Authors: Pacetti Simone , Tomasi-Gustafsson Egle 
Published: February 2021

AbstractThe dimension of the proton, the basic building block of matter, is still object of controversy. The most precise electron-proton scattering data at low transferred momenta are re-analyzed and the extraction of the proton radius is discussed. A recent experiment from the JLAB-CLAS collaboration gives a small value for the radius (The symbol $$R_E^\alpha $$

R
E
α

stands for the root-mean-square charge radius of the proton $$\sqrt{\langle r_E^2\rangle }$$

⟨

r
E
2

⟩

, obtained by the experimental or theoretical Collaboration $$\alpha $$
α
.) $$R_E^\mathrm{CLAS}= (0.831\pm 0.007_\mathrm{stat}\pm 0.012_\mathrm{syst})$$

R
E
CLAS

=

(
0.831
±
0
.

007
stat

±
0
.

012
syst

)

fm (Xiong et al. in Nature 575:147, 2019), in contrast with previous electron scattering experiments, in particular with the MAINZ experiment (Bernauer et al. (A1 Collaboration), Phys. Rev. C 90:015206, 2014) that concluded $$R_E^\mathrm{MAINZ}= (0.879\pm 0.005_\mathrm{stat}\pm 0.004_\mathrm{syst}\pm 0.002_\mathrm{model}\pm 0.004_\mathrm{group})$$

R
E
MAINZ

=

(
0.879
±
0
.

005
stat

±
0
.

004
syst

±
0
.

002
model

±
0
.

004
group

)

fm. The experimental results are re-analyzed in terms of different fits of the cross section and of its discrete derivative with analyticity constraints. The uncertainty on the derivative is two orders of magnitude larger than the error on the measured observable, i.e., the cross section. The systematic error associated with the radius is evaluated taking into account the uncertainties from different sources, as the extrapolation to the static point, the choice of the class of fitting functions, and the range of the data sample.
Hepatobiliary Cancer Risk in Patients with Inflammatory Bowel Disease: A Scandinavian Population-Based Cohort Study
Authors: Erichsen Rune , Olén Ola , Sachs Michael C. , Pedersen Lars , Halfvarson Jonas , Askling Johan , Ekbom Anders , Ludvigsson Jonas F. , Sørensen Henrik Toft 
Published: February 2021

Abstract

Background:
Inflammatory bowel disease (IBD) has been associated with hepatobiliary cancer, but existing evidence is poor. We evaluated risk of death from hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), and extrahepatic cholangiocarcinoma (ECC) among patients with IBD.

Methods:
This Swedish/Danish population-based cohort study (1969–2017) followed patients with IBD and 1:10 matched population comparators from their diagnosis/match date until death, emigration, or end of follow-up.

Results:
Among the 97,496 patients with ulcerative colitis/963,026 comparators, we found 66/390 HCC-deaths, 120/173 ICC-deaths, and 91/220 ECC-deaths (median follow-up 10 years); the 10-year-mortality was 0.5‰ (per mille) for HCC, 0.6‰ for ICC, and 0.4‰ for ECC, which decreased to 0.3‰, 0.4‰, and 0.2‰, respectively, in 2003–2017. Overall hazard ratios (HR) were 1.83 [95% confidence interval (CI), 1.41–2.38] for HCC-, 7.33 (95% CI, 5.81–9.25) for ICC-, and 4.46 (95% CI, 3.49–5.70) for ECC-deaths. A total of 22/66 HCC-deaths, 87/120 ICC-deaths, and 55/91 ECC-deaths occurred among patients with ulcerative colitis with primary sclerosing cholangitis (PSC), corresponding to 10-year-mortality of 6.7‰, 26.2‰, and 17.2‰, respectively. Among 47,399 patients with Crohn's disease (median follow-up 11 years), 10-year-mortality from HCC (n = 28), ICC (n = 28), and ECC (n = 24) were 0.3‰, 0.1‰, and 0.3‰, respectively, and corresponding HRs were 1.96 (95% CI, 1.31–2.93), 3.33 (95% CI, 2.19–5.09), and 3.10 (95% CI, 1.97–4.87). One of 28 HCC-deaths, 14/28 ICC-deaths (10-year-mortality 19‰), and 12/24 ECC-deaths (10-year-mortality 14‰) occurred after PSC.

Conclusions:
Risk of HCC-, ICC-, and ECC-deaths was low in patients with IBD and decreased over time. However, a large proportion of deaths occurred after PSC.

Impact:
Guidelines on specific surveillance strategies for patients with IBD with PSC, but not those without PSC, are needed.
Basophil Blood Cell Count Is Associated With Enhanced Factor II Plasma Coagulant Activity and Increased Risk of Mortality in Patients With Stable Coronary Artery Disease: Not Only Neutrophils as Prognostic Marker in Ischemic Heart Disease
Authors: Pizzolo Francesca , Castagna Annalisa , Olivieri Oliviero , Girelli Domenico , Friso Simonetta , Stefanoni Filippo , Udali Silvia , Munerotto Veronica , Baroni Marcello , Cetera Vera , Luciani Giovanni Battista , Faggian Giuseppe , Bernardi Francesco , Martinelli Nicola 
Published: February 2021

Background
White blood cell count, which is inexpensive and widely available in clinical practice, has been proposed to provide prognostic information in coronary artery disease (CAD). Elevated levels of white blood cell subtypes may play different roles in atherothrombosis and predict cardiovascular outcomes.

Methods and Results
The association between white blood cell counts and mortality was evaluated in 823 subjects with angiographically demonstrated and clinically stable CAD in an observational–longitudinal study. The correlation among white blood cell counts and factor II plasma coagulant activity was analyzed in 750 subjects (554 CAD and 196 CAD‐free) not taking anticoagulant drugs. Subjects with overt leukocytosis or leukopenia were excluded. In the longitudinal study after a median follow‐up of 61 months, 160 (19.4%) subjects died, 107 (13.0%) of whom from cardiovascular causes. High levels of neutrophils, monocytes, eosinophils, and basophils were associated with an increased mortality rate. In multiadjusted Cox regression models, only neutrophils and basophils remained predictors of total and cardiovascular mortality. The associations remained significant after adjustment for traditional cardiovascular risk factors and by including D‐dimer and the chemokine CXCL12 in the regression models. Neutrophils and basophils were also significant predictors of factor II plasma coagulant activity variability after adjustment for blood cell counts, age, sex, inflammatory markers, CAD diagnosis, and prothrombin G20210A polymorphism. Factor II plasma coagulant activity was similarly increased in subjects with high neutrophil and basophil counts and in carriers of the prothrombin 20210A allele.

Conclusions
Both high neutrophil and basophil blood counts may predict mortality in patients with clinically stable CAD and are associated with enhanced factor II plasma coagulant activity, thereby suggesting underlying prothrombotic mechanisms.
Blood Biomarker Panels for the Early Prediction of Stroke‐Associated Complications
Authors: Faura Júlia , Bustamante Alejandro , Reverté Silvia , García‐Berrocoso Teresa , Millán Mónica , Castellanos Mar , Lara‐Rodríguez Blanca , Zaragoza Josep , Ventura Oriol , Hernández‐Pérez María , van Eendenburg Cecile , Cardona Pere , López‐Cancio Elena , Cánovas David , Serena Joaquín , Rubiera Marta , Dávalos Antoni , Montaner Joan 
Published: February 2021

Background
Acute decompensated heart failure (ADHF) and respiratory tract infections (RTIs) are potentially life‐threatening complications in patients experiencing stroke during hospitalization. We aimed to test whether blood biomarker panels might predict these complications early after admission.

Methods and Results

Nine hundred thirty‐eight patients experiencing ischemic stroke were prospectively recruited in the Stroke‐Chip study. Post‐stroke complications during hospitalization were retrospectively evaluated. Blood samples were drawn within 6 hours after stroke onset, and 14 biomarkers were analyzed by immunoassays. Biomarker values were normalized using log‐transformation and
Z
score. PanelomiX algorithm was used to select panels with the best accuracy for predicting ADHF and RTI. Logistic regression models were constructed with the clinical variables and the biomarker panels. The additional predictive value of the panels compared with the clinical model alone was evaluated by receiver operating characteristic curves. An internal validation through a 10‐fold cross‐validation with 3 repeats was performed. ADHF and RTI occurred in 19 (2%) and 86 (9.1%) cases, respectively. Three‐biomarker panels were developed as predictors: vascular adhesion protein‐1 >5.67, NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) >4.98 and
d
‐dimer >5.38 (sensitivity, 89.5%; specificity, 71.7%) for ADHF; and interleukin‐6 >3.97, von Willebrand factor >3.67, and
d
‐dimer >4.58 (sensitivity, 82.6%; specificity, 59.8%) for RTI. Both panels independently predicted stroke complications (panel for ADHF: odds ratio [OR] [95% CI], 10.1 [3–52.2]; panel for RTI: OR, 3.73 [1.95–7.14]) after adjustment by clinical confounders. The addition of the panel to clinical predictors significantly improved areas under the curve of the receiver operating characteristic curves in both cases.

Conclusions
Blood biomarkers could be useful for the early prediction of ADHF and RTI. Future studies should assess the usefulness of these panels in front of patients experiencing stroke with respiratory symptoms such as dyspnea.
Nematicidal activity of the tropane alkaloids hyoscyamine and scopolamine against the root-knot nematode Meloidogyne incognita
Authors: Babaali Djaafar , Roeb Johannes , Zaidat Sabri , Reguige Bouchra , Hammache Miloud , Hallmann Johannes 
Published: February 2021

Summary
Alkaloids and alkaloid-producing plants have the potential to reduce crop damage by plant-parasitic nematodes. In a series of in vitro experiments, the nematicidal activity of the tropane alkaloids, hyoscyamine and scopolamine, and a mixture of both on the root-knot nematode, Meloidogyne incognita, was tested. Solutions of 16 mg of compound per ml of solvent were used in concentrations of 80-1280 μg ml−1 of water. Inactivity of second-stage juveniles of M. incognita increased with increasing concentration and exposure time. Lethal concentrations (LC50) after 120 min of exposure ranged from 182.4 μg ml−1 for scopolamine to 318.4 μg ml−1 for hyoscyamine and 332.8 μg ml−1 for the combination of both alkaloids. Similarly, the same concentrations of scopolamine inhibited hatching of M. incognita to a greater extent than hyoscyamine. In a glasshouse experiment, M. incognita was not able to penetrate the roots, induce galls and reproduce on Datura stramonium, D. innoxia and D. tatula. Results indicate that the tropane alkaloids hyoscyamine and scopolamine contained in Datura plants express a strong nematicidal activity against M. incognita and could possibly be used for an alternative and sustainable nematode management.
British Material Diplomacy in Precolonial Uganda: The Gift Exchanges of John Hanning Speke, 1860-1863
Authors: Bennett Alison 
Published: February 2021

Summary
In recent decades the interdisciplinary study of elite gift exchange in various geographical and temporal contexts has transformed historians’ understanding of colonial diplomacy. By combining analysis of textual, visual and material sources with theoretical approaches to material culture and gift exchange from anthropology, scholars have increasingly come to examine colonial diplomacy not only through the high-politics and text-based operations of bureaucrats in imperial metropoles, but also as a material and cultural project operating through the local and personal. This essay uses the published account of John Hanning Speke (1863) and his descriptions of ‘gift exchanges’ in present-day Uganda to understand the materiality of early British diplomacy there. As Speke was the first Briton to reach Uganda, it examines how gift exchanges impacted the logistics and outcomes of his visit. Re-examining his text this way reveals the importance of material knowledge, performance and exchange in early cross-cultural encounters in the region.
The Discovery of African Dust Transport to the Western Hemisphere and the Saharan Air Layer: A History
Authors: Prospero Joseph M. , Delany Anthony C. , Delany Audrey C. , Carlson Toby N. 
Published: February 2021

AbstractThere is great interest in wind-borne mineral dust because of the role that dust plays in climate by modulating solar radiation and cloud properties. Today, much research focuses on North Africa because it is Earth’s largest and most persistently active dust source. Moreover, this region is expected to be greatly impacted by climate change, which would affect dust emission rates. Interest in dust was stimulated over 50 years ago when it was discovered that African dust was frequently transported across the Atlantic in great quantities. Here we report on the initial discovery of African dust in the Caribbean Basin. We show that there were three independent “first” discoveries of African dust in the 1950s through the 1960s. In each case, the discoverers were not seeking dust but, rather, they had other research objectives. The meteorological context of African dust transport was first elucidated in 1969 with the characterization of the Saharan air layer (SAL) and its role in effecting the efficient transport of African dust over great distances to the Western Hemisphere. The link between dust transport and African climate was established in the 1970s and 1980s when dust transport to the Caribbean increased greatly following the onset of severe drought in the Sahel. Here we chronicle these events and show how they contributed to our current state of knowledge.
In Situ Measurements of Wind and Turbulence by a Motor Glider in the Andes
Authors: Wildmann Norman , Eckert Ramona , Dörnbrack Andreas , Gisinger Sonja , Rapp Markus , Ohlmann Klaus , van Niekerk Annelize 
Published: February 2021

AbstractA Stemme S10-VT motor glider was equipped with a newly developed sensor suite consisting of a five-hole probe, an inertial navigation and global navigation satellite system, two temperature sensors, and a humidity sensor. By design, the system provides three-dimensional wind vector data that enable the analysis of atmospheric motion scales up to a temporal resolution of 10 Hz. We give a description of components and installation of the system, its calibration, and its performance. The accuracy for the measurement of the wind vector is estimated to be on the order of 0.5 m s−1. As part of the Southern Hemisphere Transport, Dynamics, and Chemistry (SouthTRAC) field campaign, 30 research flights were performed from September 2019 to January 2020. We present statistical analysis of the observations, discriminating pure motor flights from soaring flights in the lee waves of the Andes. We present histograms of flight altitude, airspeed, wind speed and direction, temperature, and relative humidity to document the atmospheric conditions. Probability density functions of vertical air velocity, turbulence kinetic energy (TKE), and dissipation rate complete the statistical analysis. Altogether, 41% of the flights are in weak, 14% in moderate, and 0.4% in strong mountain wave conditions according to thresholds for the measured vertical air velocity. As an exemplary case study, we compare measurements on 11 September 2019 to a high-resolution numerical weather prediction model. The case study provides a meaningful example of how data from soaring flights might be utilized for model validation on the mesoscale and within the troposphere.
Knowledge, contact and stigma of mental illness: Comparing three stakeholder groups in Hong Kong
Authors: Ran Mao-Sheng , Peng Man-Man , Yau Yuen Yum , Zhang Tian-Ming , Li Xu-Hong , Wong Irene Yin Ling , Ng Siuman , Thornicroft Graham , Chan Cecilia Lai-Wan , Lu Lin 
Published: February 2021

Background: It remains unknown what the impacts of multiple dimensions of contact (e.g. level, quantity and quality) are on the stigma of mental illness. Aims: To explore the relationship between the multiple dimensions of contact and stigma of mental illness among family members (FM), mental health workers (MHW) and community residents (CR) in Hong Kong. Methods: The stigma, contact and knowledge were measured in FM, MHW and CR in Hong Kong. Multiple regression analyses were used. Results: MHW ( n = 141) had higher knowledge, more contact and lower stigma of mental illness than CR ( n = 95) or FM ( n = 62). Knowledge and contact quality were significantly associated with lower stigma of mental illness in the three groups. However, contact level and contact quantity were not significantly associated with most stigma components. The contact level was positively associated with stigma of mental illness among FM and CR. Conclusions: The results of this study highlight the differences in knowledge, contact and stigma of mental illness among different stakeholder groups. This study suggests that positive contact (e.g. equal, supportive, voluntary and pleasant contact) reduces stigma of mental illness, while negative contact (e.g. unfriendly, unsupportive, unpleasant contact) may increase stigma. The Enhancing Contact Model (ECM) should be tested in future anti-stigma interventions.
Successful Treatment of Pediatric Refractory Burkitt Lymphoma PTLD after Liver Transplantation using Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy
Authors: Wang Tianyi , Feng Mingxuan , Luo Chengjuan , Wan Xinyu , Pan Ci , Tang Jingyan , Xue Feng , Yin Minzhi , Lu Dongqing , Xia Qiang , Li Benshang , Chen Jing 
Published: February 2021

In the immunocompromised setting, recipients of solid-organ or hematopoietic stem-cell transplants carry an increased risk of post-transplant lymphoproliferative disorder (PTLD). Burkitt lymphoma (BL) PTLD is a rare form of monomorphic B-cell PTLD, which lacks a standard best treatment. Here, we report the successful treatment of refractory BL-PTLD with autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy. A male patient was diagnosed with BL-PTLD, with an increasing Epstein-Barr virus (EBV) viral load, at 21 months after undergoing living liver transplantation from his mother due to neonatal biliary atresia. After 10 cycles rituximab +/− intensive chemotherapy and surgical tumor resection, the tumors significantly advanced. Next-generation sequencing (NGS) was performed on formalin-fixed paraffin-embedded tumor tissue, revealing one mutation in exon 5, TP53: p.A159 V, which may be associated with chemo-resistance. Thus, treatment was started with autologous anti-CD19 CAR T-cell therapy. We administered 9.0 × 106/kg autologous anti-CD19 CAR T-cells, after conditioning with cyclophosphamide and fludarabine. Unexpectedly, the patient experienced only mild (Grade II) cytokine release syndrome (CRS) without neurotoxicity. Finally, he went into complete remission (CR), and has achieved 16-month event-free survival to date. In addition, liver function has remained stably within the normal range without any immunosuppressive therapy. The literature includes only five previously reported BL cases treated with CAR T-cell therapy. In conclusion, the present case suggests that autologous anti-CD19 CAR T-cell therapy may represent a new therapeutic option for some cases of refractory BL-PTLD. Clinical trial number: ChiCTR2000032211.