bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelvic and breast ultrasound abnormalities and associated metabolic disturbances in girls with premature pubarche due to adrenarche
Authors: Aydin Banu K. , Kadioglu Alev , Kaya Gamze A. , Devecioglu Esra , Bas Firdevs , Poyrazoglu Sukran , Gokcay Gulbin , Darendeliler Feyza 
Published: December 2021

AbstractObjectivePremature adrenarche (PA) has been suggested as a risk factor for future health problems, such as metabolic syndrome and early menarche. However, not all girls with PA have these features and it is not certain who will develop them. We propose that these abnormalities might be identified earlier, even before they are visible.DesignCase‐control study.SettingTertiary care hospital.ParticipantsForty‐eight girls with premature pubarche due to PA and age (mean age 7.6 ± 1.0 years), weight, body mass index (BMI), birth weight and gestational age‐matched 49 girls with no palpable breast tissue.MeasurementsEarly pubertal pelvic and breast ultrasonographic changes and their associations with obesity and metabolic parameters were evaluated. Blood samples were collected, breast and pelvic ultrasound examinations were performed and bone ages were assessed.ResultsGirls with PA were taller and their bone ages were higher (p = .049 and p = .005). Fasting blood glucose, insulin, triglycerides, high‐density lipoprotein and low‐density lipoprotein cholesterol were not different between the groups. Luteinizing hormone (LH), follicle‐stimulating hormone (FSH) and estradiol were not different either. Ultrasonography revealed breast gland tissue in 30% of girls with PA and 5% of controls (p = .006). Uterine volume and endometrial thickness were higher in girls with PA (p = .03 and p = .04). Endometrial thickness was positively associated with serum insulin levels in the whole study group and after adjusting for age, diagnosis, BMI, mean ovarian volume and LH, FSH, estradiol levels, this association remained with a borderline p‐value (R2 = 0.486, p = .050).ConclusionsWe found early changes in uterus and breast glands of girls with PA and endometrial thickness was positively associated with insulin levels.
Measuring children's behavioral regulation in the preschool classroom: An objective, sensor‐based approach
Authors: Koepp Andrew E. , Gershoff Elizabeth T. , Castelli Darla M. , Bryan Amy E. 
Published: December 2021

AbstractChildren's abilities to regulate their behaviors are critical for learning and development, yet researchers lack an objective, precise method for assessing children's behavioral regulation in their everyday environments such as their classrooms. This study tested a sensor‐based approach to assess preschool children's behavioral regulation objectively, precisely, and naturalistically. Children wore accelerometer devices as they engaged in center‐based play in their preschool classrooms for roughly 45 min (N = 50 children, 48% female, mean age = 4.5 years). Set to record data each second, these devices collected information about children's movement (N = 140,564 observations). From these data, the authors extracted concrete behaviors hypothesized to index behavioral regulation and compared them with teacher and observer ratings of the same. Initiating movement more frequently, staying seated in activities for shorter amounts of time, and spending a greater amount of time in motion were related to lower ratings of attention and inhibitory control by teachers and by observers of classroom group time, median r = .45, p < .01. These same objectively measured behaviors showed only weak associations with children's performance on assessments of cognitive regulation, median r = .11, p = .47. The findings indicate that ambulatory accelerometers can capture movement‐based indicators of children's behavioral regulation in the classroom setting and that performance on measures of cognitive regulation does not strongly predict children's behavior in the classroom. As an unobtrusive and objective measure, actigraphy may become an important tool for studying children's behavioral regulation in everyday contexts.
Relationship between COVID‐19 and movement disorders: A narrative review
Authors: Schneider Susanne A. , Hennig Anita , Martino Davide 
Published: December 2021

AbstractBackground and purposeThe scientific literature on COVID‐19 is increasingly growing.MethodsIn this paper, we review the literature on movement disorders in the context of the COVID‐19 pandemic.ResultsFirst, there are a variety of transient movement disorders that may manifest in the acute phase of COVID‐19, most often myoclonus, with more than 50 patients described in the literature. New onset parkinsonism, chorea, and tic‐like behaviours have also been reported. Movement disorders as a side effect after COVID‐19 vaccination are rare, occurring with a frequency of 0.00002–0.0002 depending on the product used, mostly manifesting with tremor. Current evidence for potential long‐term manifestations, for example, long COVID parkinsonism, is separately discussed. Second, the pandemic has also had an impact on patients with pre‐existing movement disorder syndromes, with negative effects on clinical status and overall well‐being, and reduced access to medication and health care. In many parts, the pandemic has led to reorganization of the medical system, including the development of new digital solutions. The movement disorder‐related evidence for this is reviewed and discussed.ConclusionsThe pandemic and the associated preventive measures have had a negative impact on the clinical status, access to health care, and overall well‐being of patients with pre‐existing movement disorders.
You can paint with all the colors of the wind, but can you educate with them too? The discriminatory impact of non‐comprehensive sex‐education in public schools
Authors: Chamlin Delilah Rose 
Published: December 2021

AbstractThroughout the United States, sexual education classes are often conducted with a narrow focus. While some states focus primarily on abstinence, others aim to teach a wider array of topics. The commonality among the curricula is that LGBTQ+ students are excluded from the conversation. Failing to include the LGBTQ+ community in sexual education enables the continuation of discrimination in nuclear school communities and on a nationwide scale. This Note proposes that all states adopt an inclusive and comprehensive curriculum tailored to present sexual education in a fashion that pays credence to the acceptance of individuals who identify as LGBTQ+.
Parathormone enhances eryptosis in patients with end stage renal disease treated by hemodialysis
Authors: Hefny Aya , Fikry Abeer A. , Zahran Mahmoud H. , Shendi Ali M. 
Published: December 2021

AbstractIntroductionParathormone (PTH) and phosphorus, which are considered as uremic toxins, are associated with reduced red cell survival, yet with unproven mechanism. We aimed to assess the relation between PTH and phosphorus levels and eryptosis in patients with CKD5d treated by hemodialysis.MethodsIn a cohort of 85 patients with CKD5d treated by conventional hemodialysis, the percent of annexin V‐binding RBCs was assessed by flow cytometry to indicate the percent of eryptotic RBCs.FindingsThe median percent of annexin V‐binding RBCs was 2.3 (1.4–4.7)%. On linear regression analysis, PTH was independently associated with the percent of annexin V‐binding RBCs (β = 0.003; 95% CI: 0.002–0.004; p < 0.001). The percent of annexin V‐binding RBCs differed significantly in patients with low PTH (<150 pg/mL; 27/85, 31.8%), target PTH (150–600 pg/mL; 32/85, 37.6%), and high PTH (>600 pg/mL; 26/85, 30.6%) groups (1.24 [0.65–1.85]; 2.46 [1.73–4.05]; and 4.82 [3.45–5.61]%, respectively; p < 0.001). Considering the tertiles of the percent of annexin V binding RBCs, PTH increased significantly from 85 (50.6–273) in the 1st to 298.3 (172.8–606.8) in the 2nd and 827.6 (357.4–1171.3) pg/mL in the 3rd tertiles (p < 0.001). Phosphorus and calcium levels as well as the CaxPh product were similar among the three tertiles (p > 0.05).DiscussionPatients with CKD5d express high rates of eryptosis. PTH excess in those patients may result in further eryptosis enhancement, and this represents a potential pathogenic mechanism linking hyperparathyroidism with the anemia of CKD.
Mechanical properties of in situ synthesized mullite‐based composite ceramics with three‐dimensional network structure
Authors: Liu Zhenying , Wu Chongmei , Xie Nan , Zhu Jinbo , Liu Yin , Huang Shouwu , Shen Xiulin , Yang Zhongde , Lin Xin , Kong Lingbing 
Published: December 2021

AbstractNeedle‐like nanocrystalline mullite powders were prepared through the molten salt process at the temperature of 900°C using coal gangue as raw material. Then, mullite‐based composite ceramics were prepared by a conventional solid‐state reaction between in situ synthesized mullite and Al2O3 powders. Effects of Al2O3 content and sintering temperatures on phase compositions, microstructure, and mechanical properties of the mullite‐based composite ceramics were also studied. The results show that mullite content productivity increase from 72% to 95%, as the sintering temperature increased from 1480°C to 1580°C, which led to the improvement in the bulk density and flexural strength of the samples. The three‐dimensional interlocking structure for mullite‐based composite ceramics was obtained by the in situ solid‐state reaction process. The maximum bulk density, flexural strength, and fracture toughness for the sample with 15 wt% Al2O3 content are 2.48 g/cm3, 139.79 MPa, and 5.62 MPa··m1/2, respectively, as it was sintered at the temperature of 1560°C for 3 h. The improved mechanical properties of mullite‐based composite ceramics maybe ascribed to good densification and increased mullite phase content, as well as to the in situ three‐dimensional network structure. Therefore, the results would provide new ideas for high‐value utilization of coal gangue.
The pursuit of relevance and impact: A review of the immediate response of the information systems field to COVID‐19
Authors: Karanasios Stan 
Published: December 2021

AbstractThe COVID‐19 pandemic demanded an immediate response from the research community, including adjustment to how researchers undertake research. As in many fields, information systems scholars attempted ‘rapid response’ research that addresses the immediate crisis. This paper reviews the state of the immediate research and scholarly discussion in the information systems field. Seventy‐one journal papers are reviewed. The review categorises nine thematic areas and one broad area of discussion. The methods by which information systems scholars address immediate research questions are identified. The contributions are discussed, future research directions are outlined and a model is proposed that traces the pathway from initiation of research/generation of new knowledge to practice impact. A further model is proposed to help information systems scholars clearly establish the link between the study of information systems phenomena and COVID‐19.
Sudden unexplained death versus nonautopsied possible sudden cardiac death: Findings in relatives
Authors: Dalgaard Cathrine V. , Hansen Benjamin L. , Jacobsen Elisabeth M. , Kjerrumgaard Amalie , Tfelt‐Hansen Jacob , Weeke Peter E. , Winkel Bo G. , Christensen Alex H. , Bundgaard Henning 
Published: December 2021

AbstractBackgroundInternational guidelines recommend work‐up of relatives to autopsy negative sudden cardiac death victims, denoted as sudden unexplained death (SUD) and nonautopsied possible sudden cardiac death (pSCD) victims. This study assesses and compare baseline characteristics and clinical outcome at initial evaluation and during follow‐up of relatives to SUD and pSCD victims.MethodsWe retrospectively included data from systematic screening and routine follow‐up of first‐degree relatives to SUD and pSCD victims referred to our Unit for Inherited Cardiac Diseases, Copenhagen, 2005–2018. Victims with an antemortem known inherited cardiac disease were excluded.ResultsWe included 371 first‐degree relatives from 187 families (120 SUD, 67 pSCD): 276 SUD relatives (age 33 ± 18 years, 54% men) and 95 pSCD relatives (age 40 ± 15 years, 51% men). The diagnostic yields of inherited cardiac diseases in SUD and pSCD families were 16% and 13%, respectively (p = .8). The diagnoses in SUD families were mainly channelopathies (68%), whereas pSCD families were equally diagnosed with cardiomyopathies, channelopathies, and premature ischemic heart disease. Ninety‐three percent of diagnosed families were diagnosed at initial evaluation and 7% during follow‐up (5.4 ± 3.3 years). During follow‐up 34% of relatives with a diagnosed inherited cardiac disease had an arrhythmic event, compared to 5% of relatives without established diagnosis (p < .0001).ConclusionsChannelopathies dominated in SUD families whereas a broader spectrum of inherited diseases was diagnosed in pSCD families. Most affected relatives were diagnosed at initial evaluation. The event rate was low in relatives without an established diagnosis. Long‐term clinical follow‐up may not be warranted in all relatives with normal baseline‐findings.
Prevalence and risk factors of dermatoporosis in older adults in a rehabilitation hospital
Authors: Chanca Laura , Fontaine Juliette , Kerever Sébastien , Feneche Yohann , Forasassi Christine , Meaume Sylvie , Colboc Hester 
Published: December 2021

AbstractBackgroundThe term dermatoporosis (DP) is used to describe the clinical signs and functional consequences of age‐related extreme skin fragility. It is associated with potentially severe complications, including deep dissecting hematomas and extended skin lacerations. No studies have evaluated the prevalence and risk factors of DP in adults aged 75 and older.MethodsThe aim of our study was to assess the prevalence, complications, and risk factors of DP in a cohort of older patients hospitalized in a rehabilitation center. A case–control, single‐center study was conducted between September and October 2020 in our rehabilitation ward, Rothschild Hospital, Paris, France. A senior dermatologist and a resident in geriatric medicine performed a systematic dermatological examination. The presence of DP, its stage, its location, and complications were collected, as were demographical data, comorbidities, past sun exposure, skin phototype, treatments, and biological data.ResultsA total of 101 patients (62 women, median age 86 years [extreme values 75–104]) were included. The overall prevalence of DP was 27%. Stage 1 was the most frequent. DP was mainly located on the upper limbs. Ten (37%) patients had a DP complication: eight (30%) skin lacerations and two (7%) deep dissecting hematomas. Multivariate analysis revealed a significant association between DP and age (odds ratio [OR] 5.82, 95% confidence interval [CI] 1.67–24.92, p = 0.009), smoking (OR 8.67, 95% CI 2.59–34.85, p = 0.001), recreational sun exposure (OR 4.23, 95% CI 1.30–15.21, p = 0.02), and anticoagulant therapy (OR 4.53, 95% CI 1.32–17.26, p = 0.02).ConclusionOur study is the first to analyze the prevalence and risk factors of DP in older adults in rehabilitation. Frequency of DP makes it relevant for the geriatrician and should be described more to prevent potential severe complications. A multicentric study, with inpatients and outpatients, could evaluate the prevalence of DP in a more representative older adult population.
Worldwide prevalence of inadequate work ability among hospital nursing personnel: A systematic review and meta‐analysis
Authors: Romero‐Sánchez José Manuel , Porcel‐Gálvez Ana María , Paloma‐Castro Olga , García‐Jiménez Jesús , González‐Domínguez María Eugenia , Palomar‐Aumatell Xavier , Fernández‐García Elena 
Published: December 2021

AbstractPurposeTo estimate the worldwide pooled prevalence of inadequate work ability among hospital nursing personnel using the Work Ability Index (WAI).DesignSystematic review and meta‐analysis.MethodsA systematic search was conducted on Medline/PubMed, Scopus, Web of Science, Scielo, PsychInfo, CINAHL, Nursing and Allied Health, LILACS, and Google Scholar from inception to July 2021 to identify observational studies on work ability among hospital nursing personnel using the WAI. Two researchers independently completed the study selection, quality assessments, and data extraction on the prevalence of inadequate work ability that was pooled using the random effects model. Finally, subgroup analyses were performed to explore sources of heterogeneity.FindingsA total of 42 studies were included, consisting of 24,728 subjects worldwide from 14 countries. Of these, 35 studies were included in the meta‐analytical analyses. The worldwide pooled prevalence of inadequate work ability among hospital nursing personnel was 24.7% (95% CI = 20.2%–29.4%). High levels of heterogeneity were detected in all studies. Prevalence was higher in studies where samples were composed of nurses and nursing assistive personnel (26.8%; 95% CI = 22.4%–31.5%) than in those of nurses alone (22.2%; 95% CI = 13.1%–32.9%) and in studies where the sample was over 40 (28.1%; 95% CI = 19.5%–37.5%) than in those with a sample under that age (22.4%; 95% CI = 15.8%–29.7%).ConclusionsAlmost one in four members of hospital nursing staff in the world has inadequate work ability and therefore are at risk of several negative outcomes during their working life. These prevalence data correspond to the pre‐pandemic period, so new studies should also be especially useful in quantifying the impact of the COVID‐19 pandemic on work ability in the hospital nursing workforce.Clinical relevanceThe above findings justify the launch of initiatives that include annual assessment for the early identification of inadequate work ability, offering the possibility of anticipated corrective measures. Nursing workforce older than 40 years and those belonging to the professional category of nursing assistive personnel should be priority target groups for screening and intervention to improve work ability.
Seasonal population parameters reveal sex‐related dynamics of common bottlenose dolphins in open waters of the southwestern Gulf of Mexico
Authors: Bolaños‐Jiménez Jaime , Morteo Eduardo , Fruet Pedro F. , Delfín‐Alfonso Christian A. , Secchi Eduardo R. , Bello‐Pineda Javier 
Published: December 2021

AbstractIn coastal populations of the common bottlenose dolphin, resident females are usually more abundant and have more restricted home ranges than males. Here, we studied sex‐specific population dynamics of bottlenose dolphins off the Alvarado Lagoon System, southwestern Gulf of Mexico. We used standard photo‐identification and capture‐mark‐recapture methods to determine population parameters under the superpopulation approach. Seasonal survival fluctuated around 0.96 (range: 0.80–1.00) and was equal for the sexes; recruitment of putative females (PF) and males (PM) was low, asynchronous, and reached 0.14 (range: 0.04–0.10) and 0.09 (range: 0.09–0.09), respectively, indicating high residency. PF abundance ranged from 60, 95% CI [48, 74] in the northern winds' season of 2008 to a low of 38, 95% CI [31, 47] in the dry season of 2010. PM abundance ranged from a high of 14, 95% CI [12, 16] in the northern winds' season of 2008 to a low of 9, 95% CI [7, 11] in the dry season of 2010. A regression analysis showed significant autocorrelation, and a pattern in the residuals of abundance, indicating no trends as well as temporal fluctuations that suggest a possible carrying capacity effect. Accordingly, high site fidelity, restricted ranging patterns, and low sporadic recruitment from the superpopulation are likely driving population parameters for this population.
The Impacts of Free Universal Elderly Care on the Supply of Informal Care and Labour Supply*
Authors: Hollingsworth Bruce , Ohinata Asako , Picchio Matteo , Walker Ian 
Published: December 2021

AbstractThis paper investigates the impact of introducing universal free formal personal care on informal caregiving behaviour in Scotland – in particular, we explore the extent to which free formal care might crowd out the supply of informal care. We estimate, in a difference‐in‐differences framework, that such a reform would: reduce the probability of co‐residential informal caregiving (usually, provided by spouses) by around 18% and, conditional on co‐residential caring, reduce such informal care by 1.3 hours per week. These estimates suggest that an additional hour of formal care displaces approximately 1 hour of such informal care. However, we find no displacement effect on extra‐residential informal caring (often supplied by adult daughters). We also find evidence of increases in labour market participation and hours worked.
Fetal lipidome and incident risk of food allergy: A prospective birth cohort study
Authors: Hong Xiumei , Liang Liming , Ji Hongkai , Frischmeyer‐Guerrerio Pamela , Wang Guoying , Pearson Colleen , Stampfer Meir , Hu Frank B. , Wang Xiaobin 
Published: December 2021

AbstractBackgroundLipids are proposed to be important in developing adaptive immunity and allergy. However, studies to date reported inconsistent findings.ObjectiveTo examine newborn lipidome (a comprehensive profiling of circulating lipid metabolites) on child's risk of developing food allergy (FA). The maternal‐cord joint effects of lipid metabolites on FA development were also investigated.MethodsThis study included 647 mother‐child pairs from the Boston Birth Cohort and analyzed 202 lipid metabolites in cord plasma profiled by liquid chromatography tandem mass spectrometry. FA was defined based on standard clinical criteria. Logistic regression was applied to examine the relationships between individual metabolites and risk of FA.ResultsOf the 647 children, 61 developed FA. Cord triacylglycerols of long carbon chains and multiple double bonds were significantly associated with decreased risk of FA. These associations were comparable across strata of pertinent maternal and child covariates, and were independent of maternal triacylglycerols when assessed simultaneously. Besides, cord and maternal triacylglycerols had an additive effect in association with risk of FA: Children having high (≥Median) C56:8 triacylglycerol levels in both cord and maternal plasma were at the lowest risk of developing FA (OR = 0.24, 95% CI = 0.10–0.56, p = .001), compared to those having low levels in both cord and maternal plasma.ConclusionThis is the first birth cohort study to link altered cord plasma lipidome with future risk of development FA during childhood. It calls for further investigation on triacylglycerols of long carbon chains and multiple double bonds as potential novel predictive biomarkers and therapeutic targets for FA.