bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fold-Related Fracture Distribution in Neogene, Triassic, and Jurassic Sandstone Outcrops, Northern Margin of the Tarim Basin, China: Guides to Deformation in Ultradeep Tight Sandstone Reservoirs
Authors: Wang Junpeng , Zeng Lianbo , Yang Xianzhang , Liu Chun , Wang Ke , Zhang Ronghu , Chen Xiguang , Qu Yuanji , Laubach Stephen E. , Wang Qiqi 
Published: October 2021

Abstract
Ultradeep (6-8 km depth) low-porosity sandstone oil and gas reservoirs, in the Kuqa thrust belt of Tarim Basin, are an important natural gas supply source of China. Both opening and shear-mode fractures are extremely necessary reservoir elements for gas production in these rocks but are challenging to characterize with sparse core and well log observations. Here, we use outcrops of some of the same units from four exposed folds to describe fracture types and patterns. These four folds have a range of shapes that are representative of folds at depth. At the Dongq, Kuqa, Misib, and Tuger anticlines, we analyzed fracture type, cross-cutting and abutting relations, density, spatial arrangement, kinematic aperture, orientation, and mineral fill. One-dimensional inventories, field sketches, photographs, and LiDAR imagery documented fracture patterns. Most dips of all fractures shown everywhere on the fold are greater than 60 degrees (over 50%). Fracture kinematic apertures are 3 mm to ~6 mm, and fracture density is 0.5 traces/m to ~1.5 traces/m. All fractures are divided into shear mode (or small faults) and opening mode. Shear-mode fractures, with high dips that strike N-S, mutually crosswise arranged with intersection angles of 30-60 degrees, are found extensively on the flanks of these folds. In contrast, most opening-mode fractures strike E-W, are arranged parallel to each other, and are localized in fold hinges. Besides, exposed folds (reservoir analogues, figure 1) in a proximal (hinterland, Tuger and Misib) position have fracture abundance distributions and aperture size patterns compatible with fold-related fracture development whereas distal (basinward, Kuqa and Dongq) folds lack this correlation, but patterns in distal folds might be explained by overprinted effects of lithological heterogeneity on fracture abundance or the effects of nearby faults. The positive correlation between fold-related strain and fracture spatial distribution in the northern (proximal) folds permitted inference of fracture patterns in deep wells.
Evaluation of Two Different Strategies for Schistosomiasis Screening in High-Risk Groups in a Non-Endemic Setting. A Retrospective Cohort Study.
Authors: Roade Luisa , Sulleiro Elena , Bocanegra Cristina , Salvador Fernando , Treviño Begoña , Zarzuela Francesc , Goterris Lidia , Serre-Delcor Nuria , Oliveira-Souto Inés , Aznar Maria Luisa , Pou Diana , Sánchez-Montalvá Adrián , Bosch-Nicolau Pau , Espinosa Juan , Molina Israel 
Published: October 2021

Abstract
Background: to evaluate the real-life performance of direct microscopy techniques and ELISA serology for schistosomiasis screening in a high-risk population in a non-endemic setting. Methods: a retrospective cohort study was conducted in two out-patient Tropical Medicine units in Barcelona (Spain) from 2014 to 2017. Asymptomatic adults arriving from the Sub-Saharan region were included. Schistosomiasis screening was conducted according to clinical practice following a different strategy in each setting: A) feces and urine direct examination plus S. mansoni serology if non-explained eosinophilia was present, B) S.mansoni serology plus uroparasitological examination at second-step in case of a positive serology. Demographic, clinical and laboratory features were collected. Schistosomiasis cases, clinical management and 24 months follow-up were recorded for each group.Results: Four-hundred forty individuals were included: 399 in group A, 41 in group B. The majority of the cohort were male (250, 56.4%), mainly from West African countries. No differences in sex distribution (p=0.57), age (p=0.6) and baseline eosinophilia (p=0.17) were found between both groups. Fifty schistosomiasis cases were detected (11.5% group A vs 4 % group B, p=0.733). When both microscopic and serological techniques were performed, discordant results were recorded in 18.2% (16/88)). Eosinophilia was present in 50% cases. Schistosomiasis cases were younger (p<0.001) and presented more frequently eosinophilia and elevated IgE (p<0.001). Pathological ultrasound was described in 33.3% of examinations performed (4 out of 12). Conclusions: Similar results were achieved by serology and microscopy techniques -based strategies. Serology might be prioritized for schistosomiasis screening of asymptomatic adults from endemic areas, regardless peripheric eosinophil count or IgE levels.
LncRNA Pnky Positively Regulates Neural Stem Cell Migration via Modulating mRNA Splicing and Export of Target Genes
Authors: Du Jiannan , Li Yuan , Su Yuting , Zhi Wenqian , Zhang Jiale , Zhang Cheng , Wang Juan , Deng Wensheng , Zhao Shasha 
Published: October 2021

Abstract
Directed migration of neural stem cells (NSCs) is critical for embryonic neurogenesis and the healing of neurological injuries. LncRNA Pnky was reported to regulate neuronal differentiation of NSCs. However, its regulatory effect on NSC migration has never been explored. Herein, we identified that Pnky was also a key regulator of NSC migration, as underscored by the fact that Pnky silencing restrained the migration of both NSC lines C17.2 and NE4C, whereas Pnky over-expression promoted their migration. Meanwhile, Pnky regulated the expression of a core set of critical regulators that directing NSC migration, such as MMP2, MMP9, AKT and p38MAPK, etc. Through preliminary bioinformatics, we surprisingly noticed that splicing factors U2AF1 and U2AF1L4, as well as mRNA export adaptors SARNP, Aly/Ref and THOC7, were predicted to strongly interact with Pnky. Mechanically, Pnky could co-localize and directly bind to U2AF1, SARNP, Aly/Ref and THOC7, indicating the involvement of Pnky in modulating mRNA splicing and export processes. Collectively, our data delineated that, through interacting with U2AF1, SARNP, Aly/Ref and THOC7, Pnky coupled and modulated the mRNA splicing and export of downstream factors, which consequently affected NSC migration. These findings provide a possible theoretical basis of NSC migration for brain development and damage repair.
Environmental Enrichment Protects Offspring of a Rat Model of Preeclampsia from Cognitive Decline
Authors: Lu Huiqing , Gong Lili , Xu Huangfang , Zhou Qiongjie , Zhao Huanqiang , Wu Suwen , Hu Rong , Li Xiaotian 
Published: October 2021

Abstract
Background
Preeclampsia affects 5–8% of all pregnancies and contributes to adverse pregnancy and birth outcomes. In addition to the short-term effects of preeclampsia, preeclampsia can exert long-term adverse effects on offspring. Numerous studies have demonstrated that offspring of preeclamptic women exhibit cognitive deficits from childhood to old age. However, effective ways to improve the cognitive abilities of these offspring remain to be investigated. The aim of this study was to explore whether environmental enrichment in early life could restore the cognitive ability of the offspring of a rat model of preeclampsia and to investigate the cellular and molecular mechanisms by which EE improves cognitive ability.
Methods
L-NAME was used to establish a rat model of preeclampsia. The spatial learning and memory abilities and recognition memory of 56-day-old offspring were evaluated by the Morris water maze and Novel object recognition (NOR) task. Immunofluorescence was performed to evaluate cell proliferation and apoptosis in the DG region of the hippocampus. qRT-PCR was performed to examine the expression levels of neurogenesis-associated genes, pre- and postsynaptic proteins and inflammatory cytokines. An enzyme-linked immune absorbent assay was performed to evaluate the concentration of vascular endothelial growth factor (VEGF) and inflammatory cytokines in the hippocampus.
Results
The administration of L-NAME led to increased systolic blood pressure and urine protein levels in pregnant rats. Offspring in the L-NAME group exhibited impaired spatial learning ability and memory as well as NOR memory. Hippocampal neurogenesis and synaptic plasticity were impaired in offspring from the L-NAME group. Furthermore, cell apoptosis in the hippocampus was increased in the L-NAME group. The hippocampus was skewed to a proinflammatory profile, as shown by increased inflammatory cytokine levels. EE improved the cognitive ability of offspring in the L-NAME group and resulted in increased hippocampal neurogenesis and synaptic protein expression levels and decreased apoptosis and inflammatory cytokine levels.
Conclusions
Environmental enrichment resolves cognitive impairment in the offspring of a rat model of preeclampsia by improving hippocampal neurogenesis and synaptic plasticity and normalizing the apoptosis level and the inflammatory balance.
Effect of Input Servitization On Carbon Emission Reduction: Evidence From China's Manufacturing Industry
Authors: Hao Mingrui , Tang Yiding , Zhu Shujin 
Published: October 2021

Abstract
As a new form of industry that integrates manufacturing and service, manufacturing servitization is not only conducive to high-quality economic development, but also has a positive effect on reducing carbon emissions. Using panel data of 30 provincial sub-sectors in China, this study systematically investigates the effect of manufacturing input servitization on carbon emission reduction. The results showed that input servitization can reduce carbon emissions. Concerning the regional heterogeneity, input servitization plays a relatively more important role in China’s central region. Concerning the industrial heterogeneity, the carbon reduction effect of input servitization in pollution-intensive manufacturing sectors is greater than in non-pollution sectors. Furthermore, the mediating test demonstrates that input servitization reduces carbon emissions by improving technological innovation and optimizing the structure, while technological innovation is more effective in achieving carbon emission reduction. These conclusions show that improving the input servitization level of the manufacturing industry is feasible to coordinating the development of the manufacturing industry and the attaining the goals of China’s carbon emission reduction.
SP70 is a Potential Biomarker to Identify Gastric Fundic Gland Neoplasms
Authors: Luo Rongkui , Huang Wen , Chen Lingli , Liu Yalan , Xu Lei , Zhang Xiaolei , Xu Chen , Hou Yingyong 
Published: October 2021

Abstract
Background Gastric neoplasms with fundic gland differentiation include oxyntic gland adenomas (OGAs) and gastric adenocarcinomas of fundic gland type (GA-FGs). Due to their extremely well differentiation and morphological similarity to normal fundic glands, it is usually challenging to identify these lesions in pathological diagnosis, especially in biopsy specimens. This study aims to explore and verify the potential role of a newly developed monoclonal antibody (McAb) NJ001 (SP70) in differentiating fundic neoplasms from non-neoplastic fundic gland lesions. Methods Twenty-three cases of histological confirmed gastric fundic gland neoplasms were obtained, including 12 cases of OGAs and 11 of GA-FGs. Fifty cases of fundic gland polyps (FGPs) were also obtained in the control group. Key clinicopathological information was collected. SP70 immunostaining was performed, the intensity, as well as the staining pattern was analyzed and compared. The para-tumor normal fundic glands were used as internal control.Results In normal gastric mucosa, SP70 was strongly and diffusely stained on the cytoplasm in fundic glands, but not in foveolar epithelium. Therefore, a zonal distribution of SP70 was observed in normal mucosa. FGPs (50/50, 100%) shared a similar expression pattern with normal fundic glands. In fundic gland neoplasms, a significant down-expression of SP70 was observed in both OGAs and GA-FGs. The positive rate of SP70 in fundic gland neoplasms (6/23, 26.1%) was significantly lower than that in FGPs (100%) (P＜0.0001). There was no difference of SP70 positivity between OGAs (3/12, 25.0%) and GA-FGs (3/11, 27.2%) group (P>0.05).Conclusion Down-expression of SP70 is a specific feature to fundic gland neoplasms including OGAs and GA-FGs. Therefore, SP70 can serve as a potential biomarker in the identification and differential diagnosis of fundic gland neoplasms.
Impact of Relational Continuity of Primary Care in Aged Care: A Systematic Review
Authors: Dyer Suzanne M , Suen Jenni , Williams Helena , Inacio Maria C , Harvey Gillian , Roder David , Wesselingh Steve , Kellie Andrew , Crotty Maria , Caughey Gillian 
Published: October 2021

Abstract
Background: Greater continuity of care is associated with lower patient mortality. The aim of this systematic review was to examine the impact of relational continuity between a primary care practitioner and older people receiving aged care services, in residential or home care settings, on health care resource use and person-centred outcomes.Methods: Systematic review of five databases, four trial registries and three grey literature sources to October 2020. Included studies (a) aimed to increase relational continuity with a primary care professional, (b) focus on people receiving aged care services (c) included a comparator and (d) reported outcomes of health care resource use, quality of life, activities of daily living, mortality, falls or satisfaction. Cochrane Collaboration or Joanna Briggs Institute criteria were used to assess risk of bias and GRADE criteria to guide confidence in evidence and conclusions.Results: Heterogeneity in study cohorts, settings and outcome measurement in the five included studies (one randomised) precluded meta-analysis. No included studies examined relational continuity exclusively with non-physician providers. Higher relational continuity with a primary care physician probably reduces emergency department (ED) presentations (moderate certainty evidence; high versus low continuity hazard ratio (HR) 0.90, 95% confidence interval (CI) 0.89–0.92, n=178,686; incidence rate ratio (IRR) 0.91, 95%CI 0.72–1.15, n=246) and may reduce hospital admissions slightly (low certainty evidence; high versus low continuity HR 0.94; 95%CI 0.92–0.96, n=178,686; IRR 0.91, 95%CI 0.76–1.27, n=246) for older community-dwelling aged care recipients. The benefit of providing on-site primary care in residential settings is uncertain (low certainty evidence, 2 studies, n=2,468 plus 15 care homes); whilst there are probably lower hospitalisations and may be fewer ED presentations, there may also be an increase in reported mortality and falls. The benefit of general practitioners’ visits during hospital admission is uncertain (very low certainty evidence, 1 study, n=335).Conclusion: Greater relational continuity with a primary care physician probably reduces ED presentations and may reduce hospitalisations slightly for community-dwelling aged care recipients, thus policy initiatives that increase continuity may have cost offsets. Further studies of approaches to increase relational continuity of primary care in aged care settings are needed.Registration: PROSPERO CRD42021215698
Two-fifths of women are not autonomous in maternal health service utilization: A community-based cross-sectional study
Authors: Kassahun Asmamaw , Zewdie Asrat 
Published: October 2021

Abstract
Background: Autonomy of women in health care decision-making is tremendously crucial for improved maternal health outcomes and women’s empowerment. Women with greater freedom of movement are more likely to receive maternal health services. However, little has been investigated about women’s autonomy in maternal health care decision-making and contributing factors in Ethiopia. The aim of this study was to assess decision-making autonomy on maternal health care services utilization and associated factors among women.Methods: A community-based cross-sectional study was conducted in Mettu rural Woreda, Ilu Aba Bor zone, southwest Ethiopia from June 19 to August 20, 2021. Data was collected using a pretested interviewer-administered questionnaire from 541 randomly selected women. The collected data was entered into Epi-Data version 3.1 and exported to SPSS version 22 for analysis. Bivariate and multivariate logistic regression was used to identify factors associated with women's decision-making autonomy on maternal health service utilization. The significance of association was declared by using the odds ratio with a 95% confidence interval and a p-value less than 0.05 in the multivariable model.Results: Out of 522 women included in the analysis, 322 (60.5%) (95% CI: 56.2%-64.7%) were found to be autonomous on maternal health service utilization. Age category from 30-39 years, AOR=4.27 (95%CI: 1.59-11.43), attending primary education and above, AOR=3.87 (95%CI: 2.15-6.99), greater than five family size, AOR=0.25 (95%CI: 0.15-0.41), and distance from the health facility, AOR=5.33 (95%CI: 2.50-11.33) were significantly associated with women's decision-making autonomy on maternal health care services utilization.Conclusion: Even though every woman has the right to participate in her own health care decision-making, around two fifths of them have no role in making health care decisions about their own health. Socio-demographic factors like age and education were found to influence women’s autonomy. Special attention has to be given to women living in rural areas in order to reduce their dependency through education.
Analysis of the Efficacy and Renal Prognosis of a Reduced-Dose Immunosuppressive Regimen of Mild to Moderate ANCA-Associated Renal Vasculitis
Authors: Li Ziyang , Bao Jiwen , Yao Huanzhen , Zhang Minfang , Gu Leyi , Ni Zhaohui , Wang Ling 
Published: October 2021

Abstract
ObjectivesSecondary infection caused by high-dose immunosuppressive therapy is one of the most common causes of death in patients with ANCA-associated vasculitis. This study aimed to explore whether reduced-dose immunosuppressive therapy can achieve the same efficacy while reducing secondary infection in mild to moderate ANCA-associated renal vasculitis and to determine whether early secondary infections will affect the deterioration of renal function.MethodsThe efficacy and safety of the reduced-dose regimen and standard regimen were compared using the chi-square test. The renal survival rates were estimated using the Kaplan–Meier method and compared using the log rank test. Potential variates were examined using multivariate Cox proportional hazard models to determine the risk predictors of end-stage renal disease.ResultsA total of 35 patients in the standard-dose glucocorticoid group and 23 in the reduced-dose glucocorticoid group were included. The average age of the included patients was 62.45±12.70 years, and the baseline serum creatinine was 251.35 [155.53, 445] μmol/L. Nine patients (15.52%) developed ESRD within 24 months (7 standard vs. 2 reduced, P=0.035). Multivariate Cox regression model analysis proved that baseline serum creatinine (HR: 0.007, 95% CI: 2.48-39.48, P=0.014), secondary infection rate within the first 3 months (HR: 2.28, 95% CI: 2.14 45.27, P=0.003), and persistent hematuria for more than 6 months (HR: 1.723, 95% CI: 0.043-0.738, P=0.017) were risk predictors of end-stage renal disease in ANCA-associated renal vasculitis.ConclusionThe regimen of initial reduced-dose immunosuppressive therapy can significantly reduce the secondary infection rate in mild to moderate ANCA-associated renal vasculitis patients, and the efficacy is not inferior to the standard regimen. Patients who had secondary infection within the first 3 months were at higher risk of developing ESRD.
Quantitative Susceptibility Mapping of Brain Iron Deposition in Patients with Recurrent Depression
Authors: Duan Xinxiu , Xie Yuhang , Zhu Xiufang , Chen Lei , Li Feng , Feng Guoquan , Li Lei 
Published: October 2021

Abstract
Background
Recurrence is the most significant feature of depression and the relationship between iron and depression is still lack of direct evidence in vivo.
Purpose
To explore the relationships between the brain iron and the multiple recurrent depression using quantitative susceptibility mapping (QSM).
Methods
Twenty-one patients with depression (before and after treatment) and twenty control subjects were included. Gradient-recalled echo (GRE), T1 and T2 images were acquired using a 3.0T MRI system. After QSM were reconstructed and standardized, a whole-brain and the regions of interest (ROIs) were respectively analyzed using the permutation test and voxel-wise methods. In addition, regional QSM analysis and Pearson correlation test on the susceptibility of ROIs with depression-related conditions were performed.
Results
Significant increases in susceptibility were found in multiple recurrent depression patients, which involved several brain regions. Interestingly, no susceptibility changes after treatment compared to pre-treatment (all P>0.05) and no significant correlation between susceptibility and Hamilton Depression Rating Scale (HRDS) were found. Besides, it was close to significance that those with a higher relapse frequency or a longer mean duration of single episode had a higher susceptibility in the putamen, thalamus, and hippocampus. Further studies showed susceptibility across the putamen (ρ2 = 0.27, P<0.001), thalamus (ρ2 = 0.21, P<0.001), and hippocampus (ρ2 = 0.19, P<0.001) were strongly correlated with total course of disease onset.
Conclusions
Brain iron deposition is related to the total course of disease onset, but not the severity of depression, which suggest that brain iron deposition may be a sign of brain damage in multiple recurrent depression.
Oral Probiotic Expressing Human Ethanol Dehydrogenase Attenuates Damage Caused by Acute Alcohol Consumption
Authors: Jiang Xiaoxiao , Yan Chunlong , Yuan Shouli , Zhang Hanlin , Ye Rongcai , Zhou Huiqiao , Chen Li , Jiang Rui , Zheng Kexin , Huang Yuanyuan , Jin Wanzhu , Sun Gang , Dong Meng , Liu Xiaomeng 
Published: October 2021

Abstract
Alcohol is an essential drug in human life with multiple medical functions, but excessive alcohol intake, even a single episode of binge-drinking, can cause serious damage. Reducing alcohol consumption or absorption is a direct way to alleviate this harm. Alcohol is decomposed successively by alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) in the liver. Many anti-hangover drugs are intended to increase the activity of these two enzymes, which are weakened in many people owing to gene polymorphisms. Here, we produced a high-activity human ADH1B (hADHIB)-expressing probiotic that secreted the hADH1B enzyme to decompose alcohol in the intestinal tract after oral administration. Our results showed that the oral hADHIB-expressing probiotic reduced the absorption of alcohol, prolonged alcohol tolerance time, and shortened the recovery time after drinking. Alongside, fat accumulation in liver and basal structure disorder of small intestine caused by heavy alcohol intake was improved. Therefore, the engineered probiotic has the potential to be prepared as a mate to wine. This study also demonstrated for the first time that alcohol decomposition can be catalyzed by ectopically expressed hADH1B, providing a practical basis for subsequent development of super-biological antidotes that effectively deliver multiple enzymes.