23 THE IMPROVEMENT EFFECT OF PALIPERIDONE ON ENGLISH VOCABULARY MEMORY ABILITY OF COLLEGE STUDENTS WITH SCHIZOPHRENIA
Authors: Cai Xia 
Published: February 2025

Abstract

Background
Schizophrenia is a serious mental disorder often accompanied by symptoms such as cognitive impairment and memory decline. For college students, schizophrenia not only affects their academic performance, but may also lead to interpersonal tension and self-identity crisis. College students need good memory and cognitive functions to complete academic requirements, including English vocabulary memorization. Recent studies have shown that paliperidone not only effectively improves symptoms in patients with acute schizophrenia, but may also improve their cognitive function, including memory function. Therefore, the study mainly explored the therapeutic effect of paliperidone on improving the English vocabulary memory ability of college students with schizophrenia.

Methods
The study included 60 cases of schizophrenia patients aged 18-60 from the psychiatric outpatient and inpatient departments of a certain city’s psychiatric hospital. The study used a randomized controlled experimental design to randomly divide patients into an experimental group and a control group, with 30 people in each group. The experimental group first took Paliperidone sustained-release tablets orally, and after the patient’s tolerance stabilized, they switched to using Paliperidone oral preparations for injection intervention. The control group was intervened with oral antipsychotic drugs. The intervention treatment period is 12 months, with the experimental group receiving injections once a month, with a single dose ranging from 75-150mg, while the control group takes medication once every 1-2 weeks. Before and after intervention, the study used the Positive and Negative Syndrome Scale (PANSS), Brief Psychiatric Rating Scale (BPRS), and Vocabulary Size Test (VST) as evaluation tools to assess English vocabulary mastery.

Results
Before and after the intervention in December, there were significant results in the PANSS, BPRS, and VST scale scores of patients in the experimental and control groups. From the comparison of results, the experimental group that first took oral Paliperidone sustained-release tablets and then injected Paliperidone oral formulation showed significant improvement in scale scores, and the improvement effect was significantly better than that of the control group. Among them, the PANSS score of the experimental group before intervention was as high as 5.64 ± 1.21, and the score after intervention decreased to 1.07 ± 0.21, with a statistical difference between the two (P&lt;0.05). At the same time, the BRPS score of the experimental group showed a significant downward trend before and after intervention, with statistical differences (P&lt;0.05), and the VST scale score also had statistical significance (P&lt;0.05). In addition, in the inter group comparison, the experimental group had significantly lower scores on various scales after intervention compared to the control group.

Discussion
The research results indicate that the treatment method of first taking Paliperidone sustained-release tablets orally and then injecting Paliperidone oral preparations has a significant improvement effect on the English vocabulary memory ability of college students. Long term use of paliperidone can reduce the recurrence rate of schizophrenia and improve patients’ memory ability, which is of great significance for preventing the recurrence of the disease and maintaining the long-term health status of patients.