bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Mount Hood fault zone, active faulting at the crest of the dynamic Cascade Range, north-central Oregon, USA
Authors: Madin Ian P. , Streig Ashley R. , Bennett Scott E.K. 
Published: November 2021

ABSTRACT
The Mount Hood fault zone is a N-trending, ~55-km-long zone of active faulting along the western margin of the Hood River graben in north-central Oregon. The Mount Hood fault zone occurs along the crest of the Cascade Range and consists of multiple active fault segments. It is presently unclear how much Hood River graben extension is actively accommodated on the fault zone, and how Cascade intra-arc extension accommodates regional patterns of clockwise rotation and northwest translation of crustal blocks in the Pacific Northwest region of the United States. Evidence for Holocene activity on the Mount Hood fault zone was discovered in 2009 after acquisition of high-resolution lidar topography of the area. This trip will visit sites displaying evidence of Holocene surface rupture on fault strands within the Mount Hood fault zone. Day 1 starts with a two-hour drive from Portland to Mount Hood, a 3429-m-high glaciated active volcano, where we will visit sites south of the summit along the Twin Lakes fault segment, including several fault scarps and two sites where dating of offset buried soils constrains the timing of the most recent surface-rupturing event to the Holocene. Day 1 includes two hikes of ~1 km and will be partly cross-country. The trip will overnight at the historic Timberline Lodge, an architectural masterpiece from the Civilian Conservation Corps (1933–1942) era, located at tree line on the southern flank of Mount Hood. Day 2 will visit sites north of the summit, stopping along the Blue Ridge fault segment to view the site of 2011 paleoseismic trenches and an offset glacial moraine. We will visit an unusual uphill-facing scarp in coarse talus along the Gate Creek fault segment near the north end of the Mount Hood fault zone. We will conclude Day 2 with a short hike into the Mark O. Hatfield Wilderness along the Gate Creek fault segment to view evidence of a surface-rupturing earthquake that occurred only a few centuries ago, illuminated by a nearby paleoseismic trench hand-dug in 2020. Our neotectonic and paleoseismic data are among the first efforts to document and characterize seismic sources within the Mount Hood fault zone. However, even with our new age data, fault slip rates and earthquake recurrence remain poorly constrained. With our limited earthquake timing data, it is not clear whether all segments of the Mount Hood fault zone rupture together as a ≥ M 7 earthquake, or alternatively, if the fault segments rupture independently in a sequence of smaller ~M 6–sized events.
Safety and performance of a suprachoroidal sensor for telemetric measurement of intraocular pressure in the EYEMATE-SC trial
Authors: Szurman Peter , Mansouri Kaweh , Dick H. Burkhard , Mermoud Andre , Hoffmann Esther M , Mackert Marc , Weinreb Robert N , Rao Harsha Laxmana , Seuthe Anna-Maria 
Published: November 2021

AimTo investigate the safety and performance of a telemetric suprachoroidal intraocular pressure (IOP) sensor (EYEMATE-SC) and the accuracy of its IOP measurements in open angle glaucoma (OAG) patients undergoing simultaneous non-penetrating glaucoma surgery (NPGS).MethodsProspective, multicentre, open-label, single-arm, interventional clinical trial. Twenty-four eyes of 24 patients with OAG regularly scheduled for NPGS (canaloplasty or deep sclerectomy) were simultaneously implanted with an EYEMATE-SC sensor. Six-month follow-up on the sensor’s safety and performance as well as on the level of agreement between the EYEMATE-SC measurements and IOP measurements with Goldmann applanation tonometry (GAT).ResultsThe eyes underwent canaloplasty (n=15) or deep sclerectomy (n=9) and achieved successful implantation of the sensor. No device migration, dislocation or serious device-related complications occurred. A total of 367 comparisons were included in the IOP agreement analysis. The overall mean difference between GAT and EYEMATE-SC measurements was 1.31 mm Hg (lower limit of agreement (LoA) 7.55 mm Hg; upper LoA –4.92 mm Hg). The maximum difference of 2.5 mm Hg ±3.96 (LoA 0.30–2.29) was reached on day 10 and continuously improved to an agreement of –0.15 mm Hg ±2.28 (LoA –1.24 to 0.89) after 6 months. Accordingly, the percentage of eyes within an IOP difference of ±5 mm Hg improved from 78% (day 3) to 100% (6 months).ConclusionsAfter 6 months, the EYEMATE-SC sensor was safe and well tolerated, and allowed continual IOP monitoring.Trial registration numberNCT03756662.
Prevalence and factors contributing to dental caries in 12–15-year-old school adolescents in northeast China
Authors: Li Jian , Zhang Kaiqiang , Lu Zhenfu 
Published: November 2021

ObjectivesThe present study investigated the prevalence and factors contributing to dental caries in 12–15-year-old adolescents in northeast China to provide information for dental caries promotion programmes.Design, setting and participantsA cross-sectional survey including caries examination and questionnaire was performed in Liaoning province, China. 3731 12–15-year-old school adolescents participated in the survey. School adolescents were randomly selected and received a clinical oral examination and completed questionnaires that assessed their oral health-related behaviours and attitudes.ResultsOverall, 3731 12–15-year-old school adolescents participated in the survey. The prevalence of dental caries in these adolescents was 53.65%, and the mean number of decayed–missing–filled teeth (DMFT) in the adolescents was 1.64±2.38 in northeast China, which was higher than the mean in China as a whole. A remarkable difference in DMFTwas exhibited between age groups, region and gender (p<0.05). Logistic regression analysis showed that age, region, gender and father’ education were related to the occurrence of caries in these adolescents.ConclusionThe 12–15-year-old school adolescents assessed exhibited a high prevalence of dental caries and low awareness of oral health. It is critical to protect permanent teeth, and oral and dental health education and promotion should be more comprehensively integrated into school courses for these adolescents.
Meditation involving people with cancer, medical staff and witnesses: a pilot study exploring improvement in wellness and connectedness
Authors: Prevost V , Clarisse Bénédicte , Leconte Alexandra , Delorme Claire , Benoit Sandrine , Tran Titi 
Published: November 2021

IntroductionMindfulness meditation is likely to promote better management of stress, pain and negative emotions. We propose to address the benefit of meditation in an open setting associating people with cancer (target population), medical staff and witnesses (neither patient nor medical staff). This study aims (1) to evaluate the effects of meditation on wellness improvement and (2) to identify criteria and modalities for a subsequent randomised study.Methods and analysisWe propose a longitudinal pilot study consisting of a non-randomised experimental preintervention/postintervention survey. The intervention consists in delivering a meditation programme (12 weekly meditation sessions of 1.5 hours each), specifically adapted to our target population and addressing our research hypothesis in an open setting involving people with cancer, medical staff and witnesses (equally distributed in two groups of 15 participants). The main objective is to evaluate participants’ adherence to the programme. The effects of meditation will be evaluated on stress, quality of life, feeling of personal effectiveness, on the development of mindfulness and empathy, and on satisfaction and perception of a change in quality of life. We will also measure the putative added value of ‘meditating together’. This study is expected to allow validating the evaluation tools and refining the modalities of the workshops. We expect to demonstrate the evolution that this meditation-based intervention induces in the participants. We aim to promote bridge-building, between patients, medical staff but also others. In this way, one’s own suffering may be understood in the light of others’ suffering, thereby promoting the sense of otherness and giving insights into ‘living better with’. This exploratory study will investigate the relevance of this hypothesis, which could then be explored by a randomised study.Ethics and disseminationThe protocol was approved by the local ethics committee (Comité de Protection des Personnes Est II). Trial findings will be published in peer-reviewed journals.Trial registration numberNCT04410185.
Investigating the effect of relationship satisfaction on postpartum women’s health-related quality of life in Burkina Faso: a cross-sectional analysis
Authors: Lokubal Paul , Calvert Clara , Cousens Simon , Daniele Marina , Ganaba Rasmané , Filippi Veronique 
Published: November 2021

IntroductionThe period following childbirth poses physiological, physical, social and psychological challenges to women that may affect their quality of life. Few studies in Africa have explored women’s health-related quality of life (HrQoL) and its determinants in postpartum populations, including the quality of women’s relationships with their male partners. We investigated whether relationship satisfaction was associated with better HrQoL among postpartum women in Burkina Faso, 8 months after childbirth.MethodsWe analysed data from 547 women from the control arm of a randomised controlled trial in Burkina Faso. The study outcome was a woman’s HrQoL, assessed using the cross-culturally validated WHOQOL-BREF tool, with response categories adapted for Burkina Faso. The exposure was relationship satisfaction measured using questions adapted from the Dyadic Adjustment Scale and Marital Assessment Test tools. We calculated the median HrQOL scores for the study sample, overall and for each domain of HrQOL (physical, psychological, social and environmental). The association between relationship satisfaction and HrQoL was examined using multiple linear regression models with robust SEs.ResultsPostpartum women had high median HrQoL scores in the physical (88.1), psychological (93.1), social (86.1) and environmental (74.0) domains and overall HrQoL (84.0). We found that higher relationship satisfaction is associated with increased HrQoL. After adjusting for potential confounders, we found that for each point increase in relationship satisfaction score, the increase in HrQoL was 0.39 (p<0.001) for the overall HrQoL; 0.32 (p=0.013) for the physical domain; 0.25 (p=0.037) for the psychological domain; 0.46 (p<0.001) for the social domain and 0.49 (p<0.001) for the environmental domain.ConclusionHigher relationship satisfaction is associated with higher HrQoL scores. Policies should aim to support women to cope with the challenges of childbirth and childcare in the postpartum period to improve postpartum women’s HrQoL.
Sexual harassment and organisational silencing in nursing: a cross-sectional study in Greece
Authors: Papantoniou Panagiotis 
Published: November 2021

ObjectiveThis study investigates the frequency of sexual harassment among female nurses in the Greek health system and the nurses’ reluctance to report their experiences.DesignCross-sectional study.SettingGreece.Participants1264 female nurses of working age across different settings responded to the Sexual Experiences Questionnaire (SEQ) web-based format between October 2020 and February 2021. The period investigated by the SEQ was the participant’s entire professional life. The final sample consisted of 1217 nurses with valid data on the frequency of sexually harassing behaviours (gender harassment, unwanted sexual attention, sexual coercion) and the reasons for not reporting sexual harassment.Main outcome measuresThe frequency of sexual harassment was measured in a 5-point Likert Scale (1: very often, 2: often, 3: occasionally, 4: rarely, 5: never), the decision to report/not report sexual harassment was measured in a yes/no format and the impact of sexual harassment on the physical, mental and job-related performance was measured in a 5-point Likert Scale (1: very positively, 2: positively, 3: moderately, 4: negatively, 5: very negatively).Results70% of the nurses have experienced sexual harassment at least once in their working lives, while the most frequent type is gender harassment. Male doctors are the most common perpetrators. T-tests and analysis of variance showed that private and younger nurses were more likely to experience sexual harassment while divorced nurses with 1–5 years of experience dealt with sexually coercive behaviours more frequently. 30% did not report sexual harassment because of the fear of negative consequences and beliefs that no action will be taken against the perpetrator. Multiple regression analyses showed that unwanted sexual attention and sexual coercion explain the victim’s physical and job-related adverse outcomes. Cronbach’s α was 0.939.ConclusionsThe results show that sexual harassment rates are high in the Greek health system, while many victims do not report their experiences to the authorities. This emphasises the need to implement drastic measures on behalf of the National Health Service (NHS) policy makers towards helping victims speak up without the fear of negative consequences. Nurse managers are called to implement effective policies against sexual harassment.
‘Stressed, uncomfortable, vulnerable, neglected’: a qualitative study of the psychological and social impact of the COVID-19 pandemic on UK frontline keyworkers
Authors: May Tom , Aughterson Henry , Fancourt Daisy , Burton Alexandra 
Published: November 2021

ObjectivesNon-healthcare keyworkers face distinct occupational vulnerabilities that have received little consideration within broader debates about ‘essential’ work and psychological distress during the COVID-19 pandemic. The aim of this study was therefore to explore the impact of the pandemic on the working lives and mental health and well-being of non-healthcare keyworkers in the UK.DesignIn-depth, qualitative interviews, analysed using a reflexive thematic analysis.SettingTelephone or video call interviews, conducted in the UK between September 2020 and January 2021.Participants23 participants aged 26–61 (mean age=47.2) years employed in a range of non-healthcare keyworker occupations, including transport, retail, education, postal services, the police and fire services, waste collection, finance and religious services.ResultsKeyworkers experienced adverse psychological effects during the COVID-19 pandemic, including fears of COVID-19 exposure, contagion and subsequent transmission to others, especially their families. These concerns were often experienced in the context of multiple exposure risks, including insufficient personal protective equipment and a lack of workplace mitigation practices. Keyworkers also described multiple work-related challenges, including increased workload, a lack of public and organisational recognition and feelings of disempowerment.ConclusionsIn efforts to reduce psychosocial concerns among non-healthcare keyworkers, there is a need for appropriate support during the COVID-19 pandemic and in preparation for other infections (eg, seasonal influenza) in the future. This includes the provision of psychological and workplace measures attending to the intersections of personal vulnerability and work conditions that cause unique risks and challenges among those in frontline keyworker occupations.
Health and well-being in small island communities: a cross-sectional study in the Solomon Islands
Authors: Furusawa Takuro , Pitakaka Freda , Gabriel Spencer , Sai Akira , Tsukahara Takahiro , Ishida Takafumi 
Published: November 2021

ObjectivesThis study explored the health problems of inhabitants of small South Pacific Islands under the influence of climate change, focusing on three communities in the Solomon Islands.DesignCross-sectional study of the Solomon Islands’ populations.SettingA field survey was conducted in Taro Island, a small, urbanised island with a whole-community relocation plan; Manuopo community of Reef Islands, a small remote island on an atoll environment and Sasamungga, an intermediately urbanised community on a larger island. The Sasamungga community was used for comparison.ParticipantsEach community’s participants were recruited through local health authorities, and 113, 155 and 116 adults (aged 18+ years) from Taro, Manuopo and Sasamungga, respectively, participated voluntarily.MethodsEach participant’s body height, weight and body mass index were measured. A drop of blood was sampled for malaria testing; glycated haemoglobin and C reactive protein levels, measured from another drop of blood, were markers for diabetes and inflammation, respectively. The Primary Care Screening Questionnaire for Depression measured depressive mental states.Primary and secondary outcome measuresRegarding health status, the dependent variables—communicable diseases, non-communicable diseases and mental state—and independent variables—differences in communities and socioeconomic status—were measured through health check-ups and interviews of individual participants.ResultsTaro Island inhabitants had a higher risk of obesity (OR 1.13, 95% CI 1.02 to 1.27, p=0.0189), and Manuopo inhabitants had a higher risk of depression (1.25, 95% CI 1.08 to 1.44, p=0.0026) than Sasamungga inhabitants. Manuopo inhabitants recognised more serious problems of food security, livelihood, place to live and other aspects of daily living than other communities’ inhabitants.ConclusionsThe three small island communities’ observation identified different health problems: the urbanised community and remote community had a high risk of non-communicable diseases and mental disorders, respectively. These health problems should be monitored continuously during future climate-related changes.
Performance comparison of asphalt emulsion stabilized granular base modified with cement or asphaltenes
Authors: Uddin Muhammad Misbah , Kamran Farshad , Hashemian Leila 
Published: November 2021

Asphalt emulsion is a common material used for pavement base course stabilization, and cement is usually added as an active filler to improve the stability of asphalt emulsion mixtures further. However, using cement in these mixes has several drawbacks, including high material costs and environmental issues. On the other hand, asphaltenes is a waste by-product derived from the processing of Alberta oil-sands bitumen that could be used for the same purpose. This investigation compares the impact of cement and asphaltenes as additives to asphalt emulsion-stabilized layers. To compare the performance properties, cement- and asphaltenes-modified mixtures are prepared at different concentrations. The performance properties of the modified mixtures are investigated by conducting a series of tests including Marshall stability, indirect tensile strength, IDEAL-CT, and tensile strength ratio. In addition, to evaluate low-temperature cracking resistance of the mixtures, indirect tensile strength test is conducted at 0 °C and –10 °C.
EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma
Authors: Durbin Adam D. , Wang Tingjian , Wimalasena Virangika K. , Zimmerman Mark W. , Li Deyao , Dharia Neekesh V. , Mariani Luca , Shendy Noha A.M. , Nance Stephanie , Patel Anand G. , Shao Ying , Mundada Maya , Maxham Lily , Park Paul M.C. , Sigua Logan H. , Morita Ken , Conway Amy Saur , Robichaud Amanda L. , Perez-Atayde Antonio R. , Bikowitz Melissa J. , Quinn Taylor R. , Wiest Olaf , Easton John , Schönbrunn Ernst , Bulyk Martha L. , Abraham Brian J. , Stegmaier Kimberly , Look A. Thomas , Qi Jun 
Published: November 2021

Abstract

Gene expression is regulated by promoters and enhancers marked by histone H3 lysine 27 acetylation (H3K27ac), which is established by the paralogous histone acetyltransferases (HAT) EP300 and CBP. These enzymes display overlapping regulatory roles in untransformed cells, but less characterized roles in cancer cells. We demonstrate that the majority of high-risk pediatric neuroblastoma (NB) depends on EP300, whereas CBP has a limited role. EP300 controls enhancer acetylation by interacting with TFAP2β, a transcription factor member of the lineage-defining transcriptional core regulatory circuitry (CRC) in NB. To disrupt EP300, we developed a proteolysis-targeting chimera (PROTAC) compound termed “JQAD1” that selectively targets EP300 for degradation. JQAD1 treatment causes loss of H3K27ac at CRC enhancers and rapid NB apoptosis, with limited toxicity to untransformed cells where CBP may compensate. Furthermore, JQAD1 activity is critically determined by cereblon (CRBN) expression across NB cells.

Significance:
EP300, but not CBP, controls oncogenic CRC-driven transcription in high-risk NB by binding TFAP2β. We developed JQAD1, a CRBN-dependent PROTAC degrader with preferential activity against EP300 and demonstrated its activity in NB. JQAD1 has limited toxicity to untransformed cells and is effective in vivo in a CRBN-dependent manner.
This article is highlighted in the In This Issue feature, p. 587
Inequalities in Income and Education Are Associated With Survival Differences After Out-of-Hospital Cardiac Arrest: Nationwide Observational Study
Authors: Jonsson Martin , Härkönen Juho , Ljungman Petter , Nordberg Per , Ringh Mattias , Hirlekar Geir , Rawshani Araz , Herlitz Johan , Ljung Rickard , Hollenberg Jacob 
Published: November 2021

Background:
Despite the acknowledged importance of socioeconomic factors as regards cardiovascular disease onset and survival, the relationship between individual-level socioeconomic factors and survival after out-of-hospital cardiac arrest is not established. Our aim was to investigate whether socioeconomic variables are associated with 30-day survival after out-of-hospital cardiac arrest.

Methods:
We linked data from the Swedish Registry for Cardiopulmonary Resuscitation with individual-level data on socioeconomic factors (ie, educational level and disposable income) from Statistics Sweden. Confounding and mediating variables included demographic factors, comorbidity, and Utstein resuscitation variables. Outcome was 30-day survival. Multiple modified Poisson regression was used for the main analyses.

Results:
A total of 31 373 out-of-hospital cardiac arrests occurring in 2010 to 2017 were included. Crude 30-day survival rates by income quintiles were as follows: Q1 (low), 414/6277 (6.6%); Q2, 339/6276 (5.4%); Q3, 423/6275 (6.7%); Q4, 652/6273 (10.4%); and Q5 (high), 928/6272 (14.8%). In adjusted analysis, the chance of survival by income level followed a gradient-like increase, with a risk ratio of 1.86 (95% CI, 1.65–2.09) in the highest-income quintile versus the lowest. This association remained after adjusting for comorbidity, resuscitation factors, and initial rhythm. A higher educational level was associated with improved 30-day survival, with the risk ratio associated with postsecondary education ≥4 years being 1.51 (95% CI, 1.30–1.74). Survival disparities by income and educational level were observed in both men and women.

Conclusions:
In this nationwide observational study using individual-level socioeconomic data, higher income and higher educational level were associated with better 30-day survival after out-of-hospital cardiac arrest in both sexes.