bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Probiotik Dan Metabolit Lactiplantibacillus plantarum Dad-13 Terhadap Pertumbuhan dan Pembentukan Biofilm E. coli ATCC 8739 dan S. aureus ATCC 33591
Authors: Purbowati Rini , Listyawati Agusniar Furkani , Masfufatun Masfufatun , Tjandra Lusiani , Indahsari Noer Kumala 
Published: December 2024

Latar belakang: Infeksi bakteri banyak terjadi di negara-negara berkembang, dengan angka kesakitan dan kematian yang meningkat. E. coli dan S. aureus merupakan bakteri penyebab infeksi serius pada berbagai penyakit yang terdapat di masyarakat serta di rumah sakit. Penggunaan antimikroba yang tidak tepat untuk mengobati infeksi bakteri telah menjadi penyebab utama timbulnya resistensi antibiotik pada banyak pathogen. Probiotik dan juga postbiotik dapat digunakan sebagai alternatif pengganti antibiotik. Tujuan: untuk mengetahui pengaruh probiotik dan postbiotic Lactiplantibacillus plantarum Dad-13 terhadap pertumbuhan dan pembentukan biofilm E. coli ATCC 8739 dan S. aureus ATCC 33591. Metode: penelitian ini merupakan penelitian eksperimental laboratories. Uji aktivitas antibakteri dan antibiofilm dari probiotik dan postbiotik L. plantarum subsp. plantarum Dad-13 terhadap E. coli ATCC 8739 dan S. aureus ATCC 33591 dilakukan dengan konsentrasi 25, 50, 75 dan 100 %. Analisis terhadap perubahan pertumbuhan dan biofilm yang terbentuk diukur melalui serapan OD pada panjang gelombang 490 nm menggunakan microplates reader Hasil: Uji aktivitas antibakteri probiotik L. plantarum subsp. plantarum Dad-13 hanya sedikit menunjukkan penurunan pertumbuhan atau OD, kecuali pada konsentrasi 25 % terhadap E. coli ATCC 8739. Uji aktivitas antibiofilm probiotik L. plantarum subsp. plantarum Dad-13 menunjukkan penurunan biofilm yang nyata baik terhadap E. coli ATCC 8739 maupun S. aureus ATCC 33591. Uji aktivitas antibakteri postbiotik L. plantarum subsp. plantarum Dad-13 menunjukkan hanya sedikit penurunan pertumbuhan atau OD, terhadap E. coli ATCC 8739 maupun S. aureus ATCC 33591. Uji aktivitas antibiofilm postbiotik L. plantarum subsp. plantarum Dad-13 juga hanya sedikit menunjukkan penurunan biofilm baik terhadap E. coli ATCC 8739 maupun S. aureus ATCC 33591 Kesimpulan: Probiotik L. plantarum subsp. plantarum Dad-13 menunjukkan pengaruh sebagai antibakteri yang lemah, namun menunjukkan antibiofilm yang kuat terhadap terhadap E. coli ATCC 8739 dan S. aureus ATCC 33591. Postbiotik L. plantarum subsp. plantarum Dad-13 menunjukkan pengaruh sebagai antibakteri yang lemah dan juga antibiofilm terhadap E. coli ATCC 8739 dan S. aureus ATCC 33591.
Miopatía por interacción de ciclosporina, atorvastatina y verapamilo
Authors: González-Angulo Olga , Aguilar-García Josefa Andrea , Fernández-Canedo María Inés 
Published: December 2024

Se ha descrito un aumento de toxicidad muscular cuando se administra de forma concomitante ciclosporinacon otros fármacos que interactúan con enzimas del complejo citocromo P450 3A4 (CYP3A4), tales comoatorvastatina y verapamilo. Esto se debe a su metabolización compartida por este complejo enzimático. Unaprescripción consciente y teniendo en cuenta posibles interacciones puede evitar la destrucción muscular yel riesgo de insuficiencia renal. Presentamos el caso de un varón que desarrolló una miopatía secundaria altratamiento concomitante con ciclosporina, atorvastatina y verapamilo.
Una prescripción consciente y teniendo en cuenta posibles interacciones puede evitar la destrucción muscular y el riesgo de insuficiencia renal.
Presentamos el caso de un varón que desarrolló una miopatía secundaria al tratamiento concomitante con ciclosporina, atorvastatina y verapamilo.
Fermented Parkia biglobosa seed Modulates Growth Performance, Feed Utilization and Proximate composition of Acetaminophen-Exposed Clarias gariepinus
Authors: Amuzat A. O. , Ndatsu Y. , Musa A. I. 
Published: December 2024

This study evaluates the effect of Parkia biglobosa seed on growth performance, feed utilization and proximate composition of Clarias gariepinus fingerlings exposed to acetaminophen toxicity. Formulated diets (FD1, 2, 3, 4, 5, 6, and 7) containing 0, 15, 20, 25, 30, and 35%, respectively of Parkia biglobosa seed were fed to twenty C. Gariepinus fingerlings per tank (10 L). Tank 2, 3, 4, 5, 6, and 7 had 300 mg of acetaminophen added daily. The feeding was twice daily at 2% body weight of the fish for eight weeks after the initial weight and length of the fish were taken. The results revealed a significant (p > 0.05) increase in protein, fiber and fats of formulated feeds (12.23±0.02, 50.25±0.21 and 7.50±1.42 respectively)% as compared to Acetaminophen-exposed fish fed with normal feed (10.23±0.01, 31.26±1.02 and 5.78±1.01)% of protein, fiber and fats respectively. Also, a significant (p > 0.05) increase in weight gain was observed in fish-fed formulated diets with varying graded inclusion of P. biglobosa seed (1.78±1.11gram) compared to Acetaminophen-exposed fish fed with normal feed having weight (-12.80±1.11gram). All formulated meals provided vital nutrients for growth and feed efficiency utilization in C. gariepinus exposed to toxic agents. However, formulated diets with 25, 30, and 35% inclusion of fermented P. biglobosa seed look more promising compared to others. Consumption of diets supplemented with fermented P. biglobosa seeds by the fish would improve its nutritional constituents despite its constant exposure to toxic agents.
Proposals for an algorithm for determining combat losses of personnel for the purpose of predicting changes in the combat efficiency of weapons and military equipment
Authors: Kudrytskyi Maksym , Pater Nadiya , Kostrytsia Viktoriya 
Published: December 2024

The article presents proposals for an algorithm for determining combat sanitary and irreversible losses of personnel in order to predict changes in the effectiveness of the combat use of weapons and military equipment.
To do this, the authors proposed a coefficient for maintaining the effectiveness of combat use, which takes into account the results of the joint functioning of such systems: provision of workable samples of weapons and military equipment (subsystems of production and procurement, restoration, reserve); provision of expendable material and technical means (missiles and ammunition, fuels and lubricants): training systems for military personnel (crews).
The coefficient theoretically confirms the fact that the effectiveness of combat use of a unit (subdivision) during military operations depends on the availability of combat-ready weapons and military equipment, including those equipped with trained crews, consumable material and technical resources (missiles and ammunition, materials, etc.).
Based on this, the authors proposed an algorithm for determining combat sanitary and irretrievable losses based on the use of the expert assessment method.
The fundamental novelty of the proposed proposals is that the determination of combat sanitary and irretrievable losses is carried out taking into account the amount of average daily losses of weapons and military equipment during combat operations and their structure. That is, the authors have established a relationship between the degree of damage to a weapon and military equipment sample (weak, medium and strong damage to a weapon and military equipment sample received as a result of fire from the enemy) and combat sanitary and irretrievable losses of personnel.
This allows for a more accurate determination of the number of combat-ready weapons and military equipment samples (working weapons and military equipment samples, equipped with a crew and expendable material and technical means) in a unit (subdivision), which allows for forecasting changes in the effectiveness of their combat use.
In the future, the proposed proposals can be used in headquarters (services) for planning the use of troops (forces) during combat operations.
Bimbingan Teknis Formulasi Pakan Ayam Kampung Berbasis Pakan Lokal (Ampas Sagu) Di Kelurahan Alolama Kecamatan Mandonga Kota Kendari
Authors: Abadi Musram , Nafiu La Ode , Asminaya Nur Santy , Auza Fuji Astuty , Biokimestri Asma , Kusuma Prasanjaya Putu Nara , Putri Ilahude Meygi Caesarika , Nur Afandy Muhammad , Syamsul Alam Andi 
Published: December 2024

Program ini bertujuan untuk memberikan pengetahuan tentang pakan ternak ayam kampung yang terdiri dari campuran ampas sagu. Program dilaksanakan selama 81 hari, yaitu pada bulan 14 September-30 November 2024 di Kelurahan Alolama Kecamatan Mandonga Kota Kendari. Pelaksanaan program dilakukan dalam bentuk Bimbingan Teknis (Bimtek) dan Penyuluhan kepada Kelompok Ternak Bina Karya. Adapun materi pelatihan pada program pengabdian ini, yaitu formulasi pakan ayam kampung berbasis pakan lokal (ampas sagu) di Kelurahan Alolama Kecamatan Mandonga Kota Kendari. Hasil yang diperoleh bahwa penyuluhan tentang formulasi pakan ayam kampung bebasis sumbedaya lokal (ampas sagu) dapat meningkatkan pengetahuan dan keterampilan peternak ayam kampung di Kelurahan Alolama Kecamatan Mandonga Kota Kendari. Oleh karena itu, perlu dilakukan pembinaan dan pendampingan lanjutan secara rutin dan berkala dengan model terintegrasi antara Perguruan Tinggi dan Pemerintah Daerah, agar usaha peternak ayam kampung dapat berkembang lebih baik dan produktivitasnya dapat meningkat serta menjadi sumber pendapatan rumah tangga peternak ayam kampung di Perkota
Situación financiera de las compañías de seguros frente a la inseguridad ciudadana en Ecuador
Authors: Parrales Rojas Leslie Priscilla , Paredes Floril Priscilla Rossana , Palma San Lucas Jordan Jesús 
Published: December 2024

Se destaca la relevancia de esta investigación, en función del alarmante incremento de la inseguridad en Ecuador. El objetivo fue determinar la incidencia de la inseguridad ciudadana en la situación financiera de las compañías de seguros. El estudio fue de carácter cuantitativo, diseño no experimental con corte longitudinal y alcance correlacional, mediante el coeficiente de Correlación paramétrica de Pearson. La muestra estuvo conformada por 25 empresas, los datos de los periodos 2019-2023 fueron obtenidos de la página web de la Superintendencia de Compañías, Valores y Seguros (SCVS) y procesados en el programa SPSS. Los resultados revelaron una correlación muy alta entre la inseguridad y variables como la liquidez corriente, la razón de seguridad, la rotación de activos y el riesgo crediticio, con un coeficiente de correlación de Pearson de 1. En contraste, se observó una correlación negativa débil entre la inseguridad y la rentabilidad económica, con un coeficiente de -0,177. En conclusión, la inseguridad incide en la situación financiera de las empresas del sector asegurador.
Государственные меры по снижению смертности населения Тульской области
Authors: Медведева Т.В. , Комов В.Э. 
Published: December 2024

В работе проведен анализ демографической ситуации в Тульской области, обозначены причины смертности населения, факторы повышенного риска преждевременной смертности населения. Влияние социально-экономических факторов, от которых зависит смертность населения, определено через корреляционный анализ. Рассчитаны прогнозные показатели факторов, влияющих на количество умершего населения Тульской области. Произведен прогноз числа показателей, характеризующих демографическую ситуацию в Тульской области до 2028 г. Проведен SWOT-анализ государственных мер поддержки снижения смертности населения Тульской области на основе влияния внешних и внутренних факторов. Разработаны государственные меры снижения смертности Тульской области, которые позволят повысить продолжительность жизни населения в регионе.
The paper analyzes the demographic situation in the Tula region, identifies the causes of mortality, factors of increased risk of premature mortality. The influence of socio-economic factors on which mortality depends is determined through correlation analysis. The predicted indicators of factors affecting the number of deceased people in the Tula region are calculated. A forecast of the number of indicators characterizing the demographic situation in the Tula region until 2028 is made. A SWOT analysis of government measures to support the reduction of mortality in the Tula region is carried out based on the influence of external and internal factors. Government measures to reduce mortality in the Tula region are developed, which will increase life expectancy in the region.
Политика Дании в области «зеленого» водорода
Authors: Армашова-Тельник Г.С. , Рыжова А.В. 
Published: December 2024

В статье рассматриваются стратегические документы Дании в сфере развития технологий, позволяющих преобразовать возобновляемую электроэнергию в другие формы энергетических продуктов (водород, метанол, аммиак). Анализируется создание нормативно-правовой базы и инструментов финансирования. Большинство датских проектов по производству «зеленого» водорода находится на ранних стадиях разработки. Их успех будет в значительной степени зависеть от поддержки государства, развития нормативно-правовой базы и создания спроса, в том числе посредством квот, топливных стандартов и правил государственных закупок. Дания отдает предпочтение электрификации и намерена применять данные технологии в секторах, где электрификация проблематична, также планируется экспорт «зеленого» водорода.
The article examines Denmark's strategic documents in the field of developing technologies that allow the conversion of renewable electricity into other forms of energy products (hydrogen, methanol, ammonia). The creation of a regulatory framework and financing instruments is analyzed. Most Danish green hydrogen projects are in the early stages of development. Their success will depend largely on government support, development of the regulatory framework and demand creation, including through quotas, fuel standards and public procurement rules. Denmark prioritises electrification and intends to apply these technologies in sectors where electrification is problematic, and plans to export green hydrogen.
Стартап как инновационная компания: специфика и эволюция методологических подходов (на примере Франции)
Authors: Черноуцан Е.М. 
Published: December 2024

Статья посвящена анализу специфики и эволюции понятийного аппарата стартап компаний в условиях современной Франции. В центре внимания — методологические подходы к определению понятия стартапов, оригинальность которых во многом диктуется централизованным характером ее государственного устройства и управления. Автор попытался показать многообразие официально принятых определений, новых терминов и классификаций, отражающих требования французской экосистемы стартапов в новых условиях стремительных технологических изменений. Особое внимание было уделено высокотехнологичным стартапам, которые начинают рассматриваться правительством Франции как важнейший инструмент инновационной реиндустриализации страны. Были изучены новые официальные определения для стартапов в области прорывных и глубоких технологий («start-ap DeepTech», «start-up GreenTech» и др.), а также специальное ранжирование для перспективных стартапов (Next40 и French Tech 120), способных стать лидерами международного уровня.
The article is devoted to the analysis of the specifics and evolution of the conceptual apparatus of startup companies in the context of modern France. The focus is on methodological approaches to defining the concept of startups, the originality of which is largely dictated by the centralized nature of its state structure and management. The author has attempted to show the diversity of officially accepted definitions, new terms and classifications reflecting the requirements of the French startup ecosystem in the new conditions of rapid technological change. Particular attention was paid to high-tech start-ups, which are beginning to be considered by the French government as the most important tool for the country's innovative reindustrialization. New official definitions for startups in the field of disruptive and deep technologies (“start-up DeepTech”, “start-up GreenTech”, etc.) were studied, as well as a special ranking for promising startups (Next40 and French Tech 120) capable of becoming international leaders.
Концепция стоимостной оценки бизнеса с использованием технологии искусственного интеллекта
Authors: Помулев А.А. 
Published: December 2024

В условиях стремительного развития технологий искусственного интеллекта необходимо трансформировать инструментарий стоимостной оценки. В статье анализируются недостатки, характерные для существующих подходов и методов оценки стоимости бизнеса, состоящие в низкой точности прогнозирования, субъективности экспертных оценок, ограниченности учета внешних факторов. Также отмечается сложность обработки больших объемов данных и недостаточная адаптивность традиционных методов к быстро меняющимся условиям современной экономики. Рассмотрены основные разделы искусственного интеллекта (поверхностное и глубокое машинное обучение и его основные подразделы) и их применимость с целью устранения недостатков методического инструментария стоимостной оценки бизнеса. Определена базовая концепция оценки стоимости бизнеса с использованием искусственного интеллекта, которая заключается в отдельных принципах, методах работы с показателями стоимости, с применением подходов к исследовательскому анализу данных, математических алгоритмах машинного обучения. Целевой процесс стоимостной оценки должен строиться на основе мультифункциональной диалоговой системы, на основе большой языковой модели (LLM) и ансамбля расчетных моделей, реализующих модернизированные подходы и новый синтетический подход. Статья будет полезна практикующим специалистам в области оценки стоимости бизнеса.
In the context of the rapid development of artificial intelligence technologies, it is necessary to transform the tools of valuation. The article analyzes the shortcomings characteristic of the existing approaches and methods of assessing the value of business, consisting in the low accuracy of forecasting, the subjectivity of expert assessments, and the limited consideration of external factors. It also notes the complexity of processing large amounts of data and the lack of adaptability of traditional methods to the rapidly changing conditions of the modern economy. The main sections of artificial intelligence (surface and deep machine learning and its main subsections) and their applicability in order to eliminate the shortcomings of the methodological tools for business valuation are considered. The basic concept of business valuation using artificial intelligence is determined, which consists in certain principles, methods of working with value indicators, using approaches to research data analysis, mathematical algorithms of machine learning. The target process of valuation should be based on a multifunctional dialogue system, on the basis of a large language model (LLM) and an ensemble of calculation models that implement modernized approaches and a new synthetic approach. The article will be useful to practitioners in the field of business valuation.
Diretiva Antecipada de Vontade em pacientes idosos com síndrome demencial: um exemplo de autonomia
Authors: Araújo Pedro Henrique Nunes de , Melo Catharina Machado Bandeira de , Septimio Josie Anne Vasconcelos , Martins Marcelo Henrique de Sousa e Silva , Ferreira Ana Claudia da Cunha 
Published: December 2024

A demência é uma síndrome clínica de evolução lenta, crônica e progressiva. Esse quadro representa um desafio ao paciente, devido ao declínio cognitivo e alterações de comportamento que interferem na funcionalidade e realização de atividades diárias; e aos cuidadores, devido sobrecarga física e mental relacionada ao cuidado. Dessa forma, a elaboração da Diretiva Antecipada de Vontade (DAV) torna-se ferramenta fundamental para autonomia do idoso, no que diz respeito às decisões sobre cuidado e intervenção, para o momento em que o paciente seja incapaz de tomar decisões. Objetivos: Relatar o caso de um paciente idoso com quadro demencial, visando demonstrar a importância do acompanhamento médico para avaliação progressiva do estado mental, acolhimento familiar e abordagem de elaboração de DAV. Relato: Trata-se de paciente do sexo masculino, 70 anos, portador de hipertensão arterial sistêmica, diabetes mellitus e dislipidemia, angioplastia prévia e colocação de marca-passo. Cerca de 6 meses após abordagens cardíacas, evoluiu com tristeza, anedonia, alteração de memória e diminuição de fala. Havia iniciado tratamento psiquiátrico, sem melhora, com evolução progressiva dos sintomas. Com acompanhamento em ambulatório de Psicogeriatria, foi iniciado Donepezila, com estabilidade do quadro cognitivo. Em múltiplas consultas, abordado sobre a possibilidade de elaboração de DAV. Até o momento, paciente ainda não optou por sua realização. Conclusão: A síndrome demencial representa um desafio para os pacientes e suas famílias, o que torna o acolhimento essencial. Deve haver abordagem sobre quadro progressivo e discussão de cuidados paliativos, possibilitando autonomia do paciente.
Condrossarcoma na sínfise púbica simulando massa pélvica: relato de caso
Authors: Peixoto Bruno Duarte , Magalhães Lúcia Cunha , Souza Bianca Carla Azevedo de , Viana Thais Brito , Lima Isabella Torres de , Brandão Marcella Nascimento , Araujo Marcelo Antonio Nobrega 
Published: December 2024

Condrossarcoma é um tumor maligno produtor de matriz cartilaginosa e representa o terceiro tumor primário ósseo mais comum, ocorrendo predominantemente em ossos longos entre a quarta e quinta década de vida. A grande maioria (90%) dos casos de condrossarcoma faz parte do grupo central, que surge da cavidade medular, sendo subdivididos histologicamente em grupo convencional, mesenquimal e desdiferenciado. O estudo relata um caso de condrossarcoma identificado em paciente com queixas urinárias, onde são frequentemente lesões grandes na avaliação inicial devido ao atraso no início dos sintomas, apresentando-se de forma inespecífica e com poucas alterações a radiografia convencional devido à anatomia complexa da pelve, e descrevendo seus aspectos de imagem também na Tomografia Computadorizada, Ultrassonografia, Ressonância Magnética, e características anatomopatológicas. O tratamento cirúrgico se apresenta como a principal ferramenta terapêutica, visto que a radioterapia e quimioterapia não demonstraram eficácia adequada.