bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eco-Biology of Photosynthetic Picoeukaryotes in a Monsoon Influenced Tropical Bay: A Flow Cytometric and Chemotaxonomic Approach
Authors: Mitbavkar Smita , D'souza Samantha 
Published: September 2021

Abstract
The composition and ecology of photosynthetic picoeukaryotes (PPEUK) are essential for microbial food web functioning. We hypothesize that the simultaneous use of flow cytometry (FCM) and High-Performance-Liquid-Chromatography (HPLC) tools will aid in discerning the dominant PPEUK groups contributing to abundance and biomass under prevailing environmental conditions. The PPEUK seasonal community abundance and pigment biomass were investigated from a south-west monsoon influenced tropical bay from June 2015-May 2016. A size-fractionated (< 3 µm) approach using FCM and HPLC revealed five and six PPEUK groups, respectively. Picocryptophytes dominated the PPEUK biomass under varied environmental conditions, whereas Picodiatoms contributed substantially, being abundant under turbulent, low-temperature, nutrient (NO3−, SiO44−) enriched conditions. The Picochlorophytes dominated the community numerically. The relatively higher abundance and biomass of Picoprasinophytes and a positive correlation with NO3− and NH4+ imply proliferation under higher nutrient concentrations. The least contributors to biomass were Picodinoflagellates and Picoprymnesiophytes. The relatively larger cell size of Picocryptophytes and Picodiatoms resulted in higher cumulative biomass, signifying their role in the microbial food web. Our study proposes incorporation of additional indicator pigments in algorithms used to estimate coastal picophytoplankton contribution to total phytoplankton biomass to avoid discrepancies.
Environmental Sound Classification Method Based on Two-Stream Lightweight Convolutional Neural Network
Authors: Fang Jingru , Yin Bo , Ji Xiaopeng , Du Zehua 
Published: September 2021

Abstract
Neural networks have achieved success in the task of environmental sound classification. However, the traditional neural network model has too many parameters and high computational cost. The lightweight networks solve these problems by compressing parameters, but reduce the classification accuracy. To solve the problems in existing research, we propose a two-stream model based on two lightweight convolutional neural networks, called TSLCNN-DS, which saves memory and improves the classification performance of environmental sounds. Specifically, we first used data patching and data balancing to slightly expand the amount of experimental data. Then we designed two lightweight and efficient classification networks based on the attention mechanism and residual learning. Finally, the Dempster-Shafer evidence theory is used to fuse the output of the two networks, and the two-stream model is integrated. Experiments have shown that the model has achieved a classification accuracy of 97.44% on the UrbanSound8k dataset, using only 0.12 M parameters.
The Effect of Attention Process Training (APT-II) On Cognitive and Daily Life Functioning in Patients With a Mild Cognitive Impairment: A Randomized Controlled Trial
Authors: Saba Marine , Rwabihama Jean-Paul , Bouvard Éric , Mettling Pascale , Sztulman Élise , Lemarié Nadège , Piolino Pascale , Blanchet Sophie 
Published: September 2021

Abstract
Introduction. Older adults with mild cognitive impairment (MCI) are at increased risk of developing dementia even if they do not meet the criteria for dementia. Executive control of working memory, which is implicated in divided attention, is often impaired in this population, and such impairment is a strong predictor of dementia. Slowing the development of dementia by enhancing cognitive and brain plasticity represents a current and future challenge for clinicians and researchers. Cognitive rehabilitation allows patients to compensate for cognitive deficits with the ultimate goal of reducing the impact of such deficits on everyday life. We aim to examine the effectiveness and generalization of an attention and working memory training program (Attention Process Training or APT-II) in improving cognitive and everyday functioning in patients with MCI by means of a single-blind, randomized controlled trial.Methods. Twenty-two MCI patients will be randomly assigned to either a "Cognitive Training with APT-II" group or a "Standard Care" group. Initially, patients will be administered a battery of standardized neuropsychological tests to ensure that they meet MCI criteria. The intervention will consist of a cognitive training program (APT-II) and will last 8 weeks (two sessions per week). One of the strengths of APT-II training is that it emphasizes the transfer of cognitive gains from training sessions to everyday life. To evaluate the treatment's effectiveness in improving cognitive and daily life functioning, cognitive and functional outcomes will be assessed just before, immediately after, 3 months after, and 6 months after the intervention program. A divided attention memory task performed in virtual reality will also be administered to evaluate the effects of APT-II training on the management of attentional resources in a relatively ecological situation. Perspective. If our results indicate an improvement in the cognitive and daily life performance of older adults with MCI, this non-invasive, low-cost technique may deserve increased consideration as a therapeutic intervention to delay or reverse cognitive decline an diminish the risk of developing dementia in this population.Trial registration. ClinicalTrials.gov, ID: NCT04606953, Registered on 28 October 2020.
Differentiated appendages in Isoxys illuminate origin of arthropodization
Authors: Zhang Caixia , Liu Yu , Ortega-Hernández Javier , Wolfe Joanna , Jin Changfei , Mai Huijuan , Hou Xian-guang , Guo Jin , Zhai Dayou 
Published: September 2021

Abstract
The Cambrian fossil record has produced remarkable insights into the origin of euarthropods, particularly the evolution of their versatile body plan of segments bearing specialized, jointed appendages for different functions including feeding and locomotion [01, 02]. Early euarthropod evolution involved a major transition from lobopodian-like taxa [03, 04, 05] to organisms featuring a fully sclerotized trunk (arthrodization) and limbs (arthropodization) [02, 06, 07, 08]. However, the precise origin of arthropodization remains controversial because some of the earliest branching euarthropods possess a broad dorsal carapace that obscures critical details of the trunk and appendage organization [09, 10, 11, 12, 13, 14, 15]. Here, we demonstrate the presence of fully arthropodized ventral appendages in the upper stem-group euarthropod Isoxys curvirostratus from the early Cambrian Chengjiang biota in South China. Micro-computed tomography reveals the detailed three-dimensional structure of the biramous appendages in I. curvirostratus for the first time. In addition to the raptorial frontal appendages I. curvirostratus also possesses two batches of morphologically distinct biramous limbs, with the first batch consisting of four pairs of short cephalic appendages bearing prominent endites with a feeding function, followed by a second batch of elongate trunk appendages for locomotion. Each biramous limb bears an endopod with more than 12 well-defined podomeres, and an exopod consisting of a slender shaft carrying approximately a dozen paddle-shaped lamellae. Our findings clarify the enigmatic appendicular organization of Isoxys, one of the most ubiquitous euarthropods in Cambrian Burgess Shale-type deposits worldwide [01, 10, 11, 12, 14, 15, 16, 17, 18]. Critically, our new material shows that the trunk of I. curvirostratus was not arthrodized. The phylogenetic position of isoxyiids as possibly the earliest branching members of Deuteropoda [01, 02, 07, 15, 19], suggests that arthropodized biramous appendages evolved before the pattern of full trunk arthrodization that characterizes most extant and extinct members of this successful animal phylum.
Waning of IgG, total and neutralizing antibodies 6 months post-vaccination with BNT162b2 in healthcare workers
Authors: Bayart Jean-Louis , Douxfils Jonathan , Gillot Constant , David Clara , Mullier François , Elsen Marc , Eucher Christine , Eeckhoudt Sandrine Van , Roy Tatiana , Gerin Vincent , Wieers Grégoire , Laurent Christine , Closset Mélanie , Dogné Jean-Michel , Favresse Julien 
Published: September 2021

Abstract

Data about the duration of humoral response following COVID-19 vaccines are mandatory to establish appropriate population vaccination strategy. This study reports on the antibody decline observed in a population of COVID-19 naïve and COVID-19 positive individuals having received the two dose regimen of the BNT162b2 vaccine. Six months after vaccination, a significant antibody decline was observed in both COVID-19 naïve and positive individuals. The estimated half-life of total and IgG antibodies differs and ranges from several months for total antibodies to only several weeks for IgG antibodies, explaining the significant proportions of participants with non-detectable levels of neutralizing antibodies at 6 months. Whether this decrease correlates with an equivalent drop in the clinical effectiveness against the virus will require appropriate clinical studies. Nevertheless, these data are already important to support the decision-making on the potential use of a booster dose.
Manufacturing Process of Carbon Short Fiber Reinforced Al Matrix With Preformless and Their Properties
Authors: Choi Yongbum , Meng Xuan , Xu ZheFeng 
Published: September 2021

Abstract
Conventional manufacturing process of fiber reinforced metal matrix composites via liquid infiltration processes, preform manufacturing using inorganic binders is essential. However, the procedure involves binder sintering, which requires high energy and long operating times. A new fabrication process without preform manufacturing is proposed to fabricate carbon short fiber (CSF)-reinforced aluminum matrix composites using a low-pressure infiltration method. To improve the wettability and avoid interfacial reactions in CSF/Al matrix composites, the fibers were plated with copper using electroless plating process. Various volume fractions of CSFs were used to determine optimum fiber content which would produce versatile mechanical and thermal properties. Effect of CSFs content on properties such as Vickers hardness and thermal conductivity was studied. Cu-plated CSFs showed good bonding with the Al matrix and CSFs were randomly dispersed inside the composites, with CSF content of up to 29.1 vol.%, through the new manufacturing process. It showed better fiber distribution than the composite fabricated perform with SiO2 binder, which was determined by comparing the relative frequency distribution of CSFs in composites. Vickers hardness of the composites showed an obvious improvement over that of the Al matrix, and the hardness increased as the CSF content increased. The Cu-plated CSF (14.3 vol.%) reinforced Al matrix composite exhibited the highest thermal conductivity (184.1 W·m-1·K-1). However, the thermal conductivity decreased as CSF content increased to 29.1 vol.% due to the defects in composite.
Triple Targeting of Human IMPDH and Both RdRps of SARS-CoV-2 and Rhizopus Oryzae: An in Silico Perspective
Authors: Hassan Abdel_moniem S , Elfiky Abdo A , Elgohary Alaa 
Published: September 2021

Abstract
Mucormycosis has been reported in many regions associated with SARS-CoV-2 infections during the past few months. The viral RNA-dependent RNA polymerase (RdRp) is a crucial protein target in viral and fungal pathogens. Molecular docking combined with molecular dynamics simulation (MDS) is utilized to test nucleotide-based inhibitors against the RdRps of SARS-CoV-2 solved structure and Rhizopus oryzae RdRp model built in silico. Additionally, the human Inosine monophosphate dehydrogenase (IMPDH) was targeted by the same inhibitors. The results reveal a comparable binding affinity of four nucleotide derivatives compared to remdesivir and sofosbuvir against both IMPDH and the RdRps of SARS-CoV-2 and Rhizopus oryzae, the main causing agent of mucormycosis. The binding affinities are calculated using different conformations of the RdRps after 100 ns MDS and trajectories clustering. The present study suggests the triple inhibition potential of four nucleotide inhibitors against SARS-CoV-2 & R. oryzae RdRps and the human IMPDH, while experimental validation is yet to be performed.
Deep Learning Features Encode Interpretable Morphologies within Histological Images
Authors: pour Ali Foroughi , White Brian , Park Jonghanne , Sheridan Todd , Chuang Jeffrey 
Published: September 2021

Abstract
Convolutional neural networks (CNNs) are revolutionizing digital pathology by enabling machine learning-based classification of a variety of phenotypes from hematoxylin and eosin (H&E) whole slide images (WSIs), but the interpretation of CNNs remains difficult. Most studies have considered interpretability in a post hoc fashion, e.g. by presenting example regions with strongly predicted class labels. However, such an approach does not explain the biological features that contribute to correct predictions. To address this problem, here we investigate the interpretability of H&E-derived CNN features (the feature weights in the final layer of a transfer-learning-based architecture), which we show can be construed as abstract morphological genes (“mones”) with strong independent associations to biological phenotypes. We observe that many mones are specific to individual cancer types, while others are found in multiple cancers especially from related tissue types. We also observe that mone-mone correlations are strong and robustly preserved across related cancers. Importantly, linear mone-based classifiers can very accurately separate 38 distinct classes (19 tumor types and their adjacent normals, AUC=97.1%±2.8% for each class prediction), and linear classifiers are also highly effective for universal tumor detection (AUC=99.2%±0.12%). This linearity provides evidence that individual mones or correlated mone clusters may be associated with interpretable histopathological features or other patient characteristics. In particular, the statistical similarity of mones to gene expression values allows integrative mone analysis via expression-based bioinformatics approaches. We observe strong correlations between individual mones and individual gene expression values, notably mones associated with collagen gene expression in ovarian cancer. Mone-expression comparisons also indicate that immunoglobulin expression can be identified using mones in colon adenocarcinoma and that immune activity can be identified across multiple cancer types, and we verify these findings by expert histopathological review. Our work demonstrates that mones provide a morphological H&E decomposition that can be effectively associated with diverse phenotypes, analogous to the interpretability of transcription via gene expression values.
Complete mitochondrial genome of Cultellus attenuatus and its phylogenetic implications
Authors: Li Haikun , Yu Ruihai , Ma Peizhen , Li Chunhua 
Published: September 2021

Abstract
The complete mitochondrial genome of Cultellus attenuates, a new aquaculture species, was sequenced and compared with mitogenomes from seven species of Heterodonta bivalve mollusk in the gene bank. The mitochondrial genome of C. attenuatus is 16888bp in length and contains 36 genes, including 12 protein-coding genes, 2 ribosomal RNAs and 22 transfer RNAs, and all genes are encoded on the same strand. In comparison with C. attenuates, the mitochondrial genes of the Sinonovacula constricta from the same family were not rearranged, but those of six other species from different family were rearranged to different degrees. The largest non-coding region of C. attenuatus is 1173bp in length and with the A + T content of 68.24%, located between nad2 and trnK. The results of phylogenetic analysis show that the C. attenuates and the S. constricta belonging to Cultellidae cluster into one branch while two species of Solenidae ( Solen grandis and Solen strictus) are clustering as their sister taxon. These data not only contribute to the understanding of the phylogenetic relationship of the Heterodonta, but also serve as a resource for the development of the genetic markers in aquaculture.
Performance Evaluation of Precoding Schemes for Multi User Massive MIMO System Over Nakagami-m Fading Channel
Authors: Meko Sultan.F Feisso , Tulu Muluneh Mekonnen , Bashu Terefe Bahiru 
Published: September 2021

Abstract

Nowadays, wireless communication system plays great roles in our dailyactivities and different improvements are requiring because the number of users increase from time to time. At the same time, users need high throughput and link reliability. The forthcoming generation of wireless communication will have to deal with some core requirements for serving large number of users simultaneously, upholdinghigh throughput for each user, assuring less energy consumption, etc. Inter-user interference has a major impact when a wireless communication link has a large number

of users. To maintain a particular desired quality of service, sophisticated transmission mechanisms such as interference cancellation need be implemented. As a result, MU-massive MIMO with extremely huge antenna arrays is recommended. The term ”MU-massive MIMO” refers to a system with hundreds or thousands of antennas servicing tens of thousands of customers.Inter-user interference was greatly decreased once the channel vectors were closely orthogonal. As a result, high data rates can be supplied to multiple users at the same time. In this work, researcher investigated performance evaluation of a MU-massive MIMO utilizing different precoding schemes (like, MMSE, ZF, MRT) over nakagami-m fading channel with CSI at base station and users’ terminal. In addition, the researcher analyzed the outcome of pilot reuse factors and shaping (m) parameter.
CIPLUKAN (PHYSALIS ANGULATA LINN.) EXTRACT AS A NATURAL ADJUVANT REMEDIES FOR SCLERODERMA
Authors: Rini Lintang Unggul 
Published: September 2021

Scleroderma or systemic sclerosis is a rare connective tissue autoimmune disorder.1 Its prevalence in Indonesia is not well recorded but scleroderma is listed as the third most common disease in rheumatology outpatient clinic in Hasan Sadikin Hospital, Bandung, West Java, Indonesia.2,3 Scleroderma is characterized by skin fibrosis, small vessel vasculopathy, and immune system abnormality. The cutaneous lesion of scleroderma is presenting with excessive collagen type-1 production and deposition, as well as exaggerated inflammatory process. There is no specific diagnosis test is available, but in most cases, there are some laboratory findings which support the diagnosis of scleroderma, such as elevated erythrocyte sedimentation rate (ESR), B lymphocyte stimulator (BAFF), C-Reactive Protein (CRP), Soluble Cd40 Ligand (sCD40L), and Procollagen Type-1 N-Terminal Propeptide (P1NP).3-6
The treatment of this autoimmune disease remains a challenge for clinicians. The current treatment for scleroderma is expensive and some side effects as well as drug resistance are reported. Some new medicines are still under research, not accessible, and too expensive for most Indonesian communities. Hence, new therapeutic options are constantly sought.7
Ciplukan herb (Physalis angulate Linn) is a medicinal plant which grows in Indonesia. It has been known for its efficacy and safety as long-term anti-inflammatory, anti-proliferative, and anti-angiogenesis agent.7 Dewi et al conducted a double â€“blind, randomized clinical trial using ciplukan herb extract as an adjuvant treatment for scleroderma. The clinical trial was performed in Jakarta and Bandung, Indonesia for 2 years. There are 59 scleroderma patients, age 15-60 years old, had stable treatment for at least 3 months, who randomly divided into treatment group (29 people) and control group (30 people). The treatment group received 250 mg ciplukan herb extract three times a day and the control group received 250 mg amylum three times a day for 12 weeks. A 35,9% skin thickness reduction was found in treatment group. It is greater than control group which only gained 6,3% reduction (p
İŞ HUKUKUNDA ZORUNLU ARABULUCULUĞUN TAKİP HUKUKUNA ETKİLERİ
Authors: KILINÇ Elif 
Published: September 2021

7036 Sayılı İş Mahkemeleri Kanunu ile daha önce ihtiyari nitelikte olan arabuluculuk, belirli iş uyuşmazlıkları için zorunlu hale getirilmiştir. Bu Kanunla yapılan düzenlemeye göre kanuna veya bireysel yada toplu iş sözleşmesine dayanan işçi veya işveren alacağı ve tazminatına ilişkin açılan davalarda arabuluculuğun dava şartı olduğu düzenlenmiştir. Buna göre iş sözleşmesinden kaynaklanan bir alacağı tahsil etmek isteyen taraf arabulucuya başvurmaksızın dava açma yoluna başvuramayacaktır. Arabuluculuk yolunun iş uyuşmazlıklarında dava şartı olarak düzenlenmesi neticesinde bu alacaklara ilişkin olarak icra ve iflas takip yollarına başvurulup başvurulamayacağı veya takip hukukuna ilişkin birtakım davaların açılıp açılamayacağı sorusu ortaya çıkmıştır. Bu kapsamda çalışmamızda ilk olarak arabuluculuğa başvurmadan önce alacaklının ilamsız icra, ilamlı icra ve iflas takip yollarına başvurma olanağı bulunup bulunmadığı değerlendirilmiştir. Ek olarak bu takip yollarında açılan ve takibin devametmesi amacına hizmet eden itirazın kaldırılması talebi, ,itirazın iptali davası, menfi tespit davası, istirdat davası ve iflas davası gibi takip hukukuna ilişkin davaların açılıp açılamayacağı konuları incelenmiştir
ACUTE EFFECT OF KINESIOTAPE APPLICATION ON SHOULDER MUSCLE STRENGTH IN MALE WHEELCHAIR BASKETBALL PLAYERS
Authors: ÜNÜVAR Bayram Sönmez , SANİOĞLU Ahmet 
Published: September 2021

Purpose: This research aims to determine the effect of kinesiotaping application on wheelchair basketball players’ shoulders.
Methods: A total of twelve wheelchair basketball players from TSK Karagücü team were involved in this research. The average age of the subjects was 31.17±7.90 years and mean body mass index was 25.41±6.96 kg/cm2. Subjects were assessed before and after combined kinesiotape application on deltoideus muscle. Muscle facilitation technique was applied to deltoideus muscle. Isokinetic parameters of the subjects’ shoulder joints were measured with Cybex NORM isokinetic dynamometer. It was taken the dominant shoulders' flexion and abduction movements into consideration for the isokinetic measurements. Measurements were repeated before and after kinesiotape applications. In isokinetic measurement, 5 repetitions at 60°/sec and 10 repetitions at 180°/sec for shoulder's muscle strength were performed. Peak torques and total works were calculated. In statistical analyses of the data, SPSS for Windows 25.0 packet program was used. Wilcoxon Test was performed in the pretest and posttest comparisons. The results were evaluated in 0.05 precision.
Results: After the evaluation of the study, an increase of the peak torques, and total works have been found out of all the players’ dominant and non-dominant shoulders’ flexions and abductions at 60o/sec and 180o/sec in favor of the kinesiotaping application (p
ADDUCTOR SQUEEZE STRENGTH AND FUNCTIONAL LEVEL IN ADOLESCENT ATHLETES WITH ADDUCTOR RELATED GROIN PAIN
Authors: ÜNÜVAR Ezgi , AKINOĞLU Bihter , KOCAHAN Tuğba , GUNEY DENİZ Hande 
Published: September 2021

Purpose: The aim of the present study was to compare adductor squeeze strength and functional levels of adolescent athletes having adductor related groin pain (ARGP) with asymptomatic controls.
Methods: A total of 52 adolescent athletes (26 in ARGP group; 26 in healthy control group) were included in the study. Visual Analog Scale was used for pain levels. Stabilizer was used to evaluate the adductor squeeze strength. Hip Outcome Score (HOS) was used to determine functional levels.
Results: Demographic characteristics were similar between groups (p> 0.05). Adductor squeeze strength were lower in ARGP group when compared to controls (p