bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tinjauan Studi Literatur: Analisis Gambaran Pelaksanaan Sensus Harian Rawat Inap
Authors: Yulia Yulfa , Oktamianiza Oktamianiza , Putra Deni Maisa , Rahmadhani Rahmadhani , Oktavia Indah 
Published: March 2021

Sensus harian adalah suatu cara untuk mengetahui jumlah pasien yang masuk, keluar, meninggal dan perpindahan antar ruangan. Tujuan dari penelitian ini adalah untuk mendeskripsikan input (SDM, SOP, sarana prasarana) dan Proses (Monitoring evaluasi) terhadap pelaksanaan sensus harian rawat inap dengan metoda studi literatur. Pelaksanaan penelitian secara studi literatur dengan melakukan analisis deskriptif dengan mendeskripsikan fakta-fakta yang ada, kemudian di analisis, mencari kesamaan, pandangan, dan ringkasan terhadap beberapa penelitian. Hasil dari penelitian ini didapatkan bahwa sebagian besar 50% pelaksanaan sensus hariannya masih banyak mengalami keterlambatan. Keterlambatan dalam pengembalian sensus disebabkan oleh karena kurangnya kesadaran SDM terhadap pentingnya data yang telah dikumpulkan bagi kepentingan rumah sakit. SOP belum telaksana dengan optimal, sarana dan prasarana pendukung kegiatan sensus tidak memadai. Disamping itu kurangnya pengawasan pimpinan terhadap pelaksanaan kegiatan pengisian data sensus. Hal ini akan memberikan dampak terhadap informasi yang akan dikeluarkan oleh rumah sakit terkait aktivitas pelayanan kesehatan yang telah diberikan kepada pasien. Dan disamping itu data yang akan dilaporkan untuk berbagai pihak-pihak yang membutuhkan data tersebut menjadi tidak akurat.
Psychological Emotions and Their Effect on Deletion The Character of Moses in the Holy Quran is a Model) (Semantic Grammatical Study
Authors: Aziz Faraidun Ahmad 
Published: March 2021

إن للإنسان انفعالات نفسية مردها مسببات خارجية أو داخلية، ولهذه الانفعالات تأثير في أفعال الإنسان وأقواله، ولعلماء النفس عناية بمسائل التعبير عند انفعال النفس الإنسانية، إذ أكدوا أن لهذه الانفعالات تأثيرا في الكلام، فيلجأ المتكلم إلى الانحراف عن النمط النحوي المعتاد الذي يشمل تغيير ترتيب الكلمات، ومن الوسائل التعبيرية في الأسلوب نجد أيضا التكرار والإسقاط (الحذف). وقد اعتمد البحث شخصية قرآنية أنموذجا للدراسة، وهي شخصية النبي موسى، إذ هي شخصية بارزة في القصص القرآنية، تشغل مساحة واسعة فيها، وتتسم هذه الشخصية ـ نتيجة لما عاناه وقاساه من أحداث عبر مسيرته في الحياة ـ بمجموعة من الانفعالات، منها انفعال الغضب والعتاب والسرور والبهجة والحزن والتسرع والتعجل والندم. فأبرز البحث تأثير تلك الانفعالات في أقوال موسى، إذ نرى حذفا للحرف والكلمة والجملة، منشؤه هذه الانفعالات التي تميّزت بها شخصيته.پوختەمرۆڤ كاردانەوە و هەڵچوونی دەروونیی ئەوتۆی هەیە كە سەرچاوەكەی هۆكارگەلی دەرەكیی یاخود ناوەكیی مرۆڤەكەن، ئەم كاردانەوە و هەڵچوونانەش كاریگەرییان لەسەر كار و گوفتاری مرۆڤەكە هەیە، زانایانی دەروونناس گرنگییەكی زۆریان بەم بوارە داوە، بەتایبەتی كاریگەرییەكانی لەسەر قسە و گوفتار. كە وادەكات هەندێكجار مرۆڤەكە لەڕێزمانی زمانەكە لابدات و وشەیەك لەقسەكانی، یاخود ڕستەیەكی تەواو بقرتێنێت، یان ڕیزبەندیی ڕێكخستنی وشە لەڕێزمانی زمانەكەدا بگۆڕێت. ئەم توێژینەوەیە گرنگیی بەم بابەتە داوە و كەسایەتیی پێغەمبەر موسای – سەلامی خوای لێبێت – وەك نمونەی توێژینەوەكە وەرگرتووە، كە كەسایەتییەكە لەقورئانی پیرۆزدا زۆر باسی ژیان و ململانێكانی لەگەڵ توێژە جۆربەجۆرەكانی دەوروبەری كراوە، بەتایبەتی بەشێكی زۆر لە دایالۆگ و قسەكانی لەقورئاندا تۆماركراون. توێژینەوەكە دەریخستووە موسا چەندین كاردانەوە و هەڵچوونی دەروونیی هەبووە، وەك (تووڕەیی، سەرزەنشتكردن، دڵخۆشی، خەمباری، ترس، پەلەكردن، پەشیمانی)، نمونەی قسەكانیشی بۆ هەریەك لەهەڵچوونەكانی هێنراوەتەوە. پاشان توێژینەوەكە ئەوەی دەرخستووە كە چۆن ئایەتەكانی قورئانی پیرۆز لەمبارەیەوە بەوردیی ئەو كاردانەوە و هەڵچوونە دەرونییانەی موسای وەك خۆی تۆماركردووە.
Significance of expression of tumor-associated microRNA-21 and -375 for predicting the course of cancer of oral cavity
Authors: Kravets О.V. , Burtyn O.V. , Borikun T.V. , Zadvornyi T.V. , Yalovenko T.M. , Kolesnik O.O. 
Published: March 2021

Aim: To investigate the features of expression of miRNA-21 and miRNA-375 in tumor cells of patients with cancer of oral cavity (COC) and to determine the possibility of their use to predict the aggressiveness of COC course. Materials and Methods: The work is based on the results of examination and treatment of 50 patients with stage II–IV COC. miRNA expression in tumor cells was analyzed by real time reverse transcription polymerase chain reaction. Results: High levels of miRNA-21 expression (> 0.26 a.u.) and miRNA-375 (> 0.36 a.u.) were determined in 72.0% and 63.0% of cases. We revealed a tendency to decreased miRNA-21 expression and increased miRNA-375 expression in tumors of patients with recurrence-free survival less than 12 months and the presence of metastatic lesions in regional lymph nodes. In patients with COC of low differentiation grade, the level of miRNA-21 was 2.0 times lower compared with tumors of moderate differentiation grade (p < 0.05), while the expression of miRNA-375, on the contrary, was higher in tumors of low differentiation grade. A decreased expression of miRNA-21 (< 0.26 a.u.) against the background of decreased levels of miRNA-375 (< 0.36 a.u.) in tumor cells was associated with worse recurrence-free survival. Conclusions: The obtained results indicate the relation between the main clinical and pathological characteristics of patients with COC and the levels of miRNA-21 and -375 expression in tumor tissue, which indicates the involvement of these miRNAs in the formation of COC malignancy evidencing on their potential usefulness as additional prognostic markers.
SAFETY PROFILE OF MIRTAZAPINE: A REAL-WORLD DISPROPORTIONALITY
Authors: Chenthamarai.G  , Prasanna.T. Lakshmi 
Published: March 2021

Introduction: Mirtazapine is an antidepressant drug that produces both noradrenergic and serotonergic activity. It is effective in treating of mild to severe depression. Proper evidence pointing to the safety of Mirtazapine is not established. The need for post-marketing surveillance (PMS) is considered most essential. This study was aimed to generate signal for unreported adverse drug reactions for Mirtazapine.
Materials and Methods: Our study retrospectively analyzed the AEs reported entered in the Adverse Events Reporting System (FAERS) databases in the last 10-years during the period of Jan 2011 to June 2020. Disproportionality analysis was done using Reporting Odds Ratio, Proportional Reporting Ratio, and Information Component with 95% confidence interval.
Results: A disproportionality analysis was done for 41 adverse events, out of these, signal for 11 adverse events was found. ROR values 10.17 being the highest for abulia and 2.22 being the lowest for homicidal Ideation. The PRR value was 10.17 being the highest for abulia and 2.22 being the lowest for homicidal ideation. The IC025 value was 1.87 for abulia and 0.27 for homicidal Ideation.
Conclusion: The present study using the Adverse Events Reporting System (FAERS) databases maintained by the FDA suggested new safety signals for Mirtazapine. Still more cohort and epidemiological studies are recommended to validate these results.
Keywords: Mirtazapine, Disproportionality analysis, Safety Signals.
Kisműholdak fejlesztése a sokoldalúság és a könnyű reprodukálhatóság tükrében
Authors: Huszár Péter , Reizinger Patrik , Milánkovich Dorottya , Széll Alexandra 
Published: March 2021

A világűr mára már nem csak a gazdasági nagyhatalmak kiváltsága. A társuló technológia fejlődésének hatására bekövetkező költségcsökkenés eredményeképpen napjainkban akár egy kis cég, alacsony költségvetéssel is megmérettetheti magát a 21. század űrversenyében. Ehhez biztosítanak tökéletes platformot a nano- és mikroműholdak, amelyek alkalmazási lehetőségei folyamatosan bővülnek. Az egyre változatosabb hasznos terhek azonban értéktelenek a sokoldalú platformok és azok alapvető alrendszerei nélkül, mint például a fedélzeti számítógép, tápegység, kommunikációs egység vagy a műhold térbeli orientációjáért felelős alrendszer (Attitude Determination and Control System – ADCS). Így felmerül az igény egy olyan univerzális műholdplatform fejlesztésére, amelyben a létfontosságú alrendszerek biztosítva vannak különböző, harmadik fél által fejlesztett hasznos terhek, illetve tudományos kísérleti eszközök számára. Ezzel létrehozhatunk egy standardizált, költséghatékony és rugalmasan bővíthető, ezáltal még szélesebb körben elérhető kisműholdas platformot. A cikkben részletesen bemutatunk egy, a fentiekben leírt követelményeknek megfelelő univerzális CubeSatplatformot, kitérünk az egyedi mérnöki módszereket és megoldásokat igénylő fejlesztési folyamatokra, a nagy megbízhatóságú szoftvertechnológia előnyeire és a platform nyújtotta új lehetőségekre.
Efficacy of Topiramate as Prophylactic Treatment of Severe Migraine in Children attending OPD of a Tertiary Care Hospital in Bangladesh- a Randomized Control Trial
Authors: Mistry Banita , Begum Shameem Ara , Saha Narayan , Sarker Shyamal , Chandra Mahua , Saha Dipa 
Published: March 2021

Background: Migraine is the most common cause of severe recurrent headache in children. Flunarizine (FNZ) is safe and effective drug for prevention of migraine in children. Topiramate (TPM) is also successful as a preventive drug for migraine in children on randomized, double-blind, placebo-controlled trials.
Objective: This study was done to observe the efficacy of Topiramate and also perform a comparison TPM and FNZ in patients with migraine of severe intensity in our situation.
Materials & Methods: This was a randomized controlled trial done from January to July, 2018. This study was carried out in the OPD of Paediatric Neurology department, National Institute of Neurosciences, (NINS) Dhaka. Forty Children, 5-15 years old diagnosed as migraine with/without aura with severe intensity were randomized either as in study group (TPM treatment group) and control group (FNZ treatment group). Primary end point of the study was to find out the efficacy and safety of both TPM and FNZ after 4 months of treatment.
Result: Post-treatment frequency of headache/month was significantly decreased in both groups (within group, p <0.001). There was no significant difference considering pre and post-treatment frequency of headache/month between two treatment groups. (pre-treatment p- 0.333 and post-treatment p- 0.401). Adverse events were not significantly different between the groups p<0.387.
Conclusion: Topiramate is equally efficacious as Flunarizine in prophylactic treatment of severe migraine in children.
Bangladesh J Child Health 2020; VOL 44 (3) :153-156
Cockayne Syndrome with ERCC8 Gene Mutation: A Case Report
Authors: Fatema Kanij , Rahman Md Mizanur , Akhter Shaheen 
Published: March 2021

Cockayne syndrome (CS) is a genetic disorder characterized by growth failure, microcephaly, cognitive delay, visual and hearing disorders. Patients usually present with dysmorphism and global delay. It is an autosomal recessive disorder, mutation of two genes ERCC8 and ERCC6 were observed. We report a 4 year old child who was diagnosed as a case of Cockayne syndrome, based on clinical, neuroimaging and genetic study findings. This case had growth failure, dysmorphism, optic atrophy, global developmental delay, intracerebral calcification and mutation of ERCC8 gene.
Bangladesh J Child Health 2020; VOL 44 (3) :181-183
Role of Racecadotril in Children with Acute Diarrhea
Authors: Sultana Azmeri , Bishwas Parijat , Islam Shahidul , Ghosh Uzzal Kumar , Iman Kazi , Afroze Sharmin , Sonia Sheikh Farjana 
Published: March 2021

Background: Diarrhea is a leading cause of illness and death among children in developing countries. Racecadotril (acetorphan), an enkephalinase inhibitor with antisecretory and anti-diarrheal actions, is an effective and safe treatment for acute diarrhea in adults and children.
Objectives: The objective of this study is to evaluate the efficacy and tolerability of racecadotril as a treatment of acute diarrhea in children.
Methods: This double-blind, randomized controlled clinical trial was conducted in Dr. MR Khan Children Hospital & Institute of Child Health over 1 year (June 2017- May 2018). The study was approved by the ethical committee of the institute. The efficacy and tolerability of racecadotril (1.5 mg/kg) administered orally 3 times daily) as adjuvant therapy to oral rehydration or intravenous fluid were compared with those of placebo in 40 children aged 3 months to 60 months of children who had acute diarrhea.
Results: During the first 72 hours of treatment, patients receiving racecadotril had a significantly lower stool output (grams per hour) than those receiving placebo. The mean (±SE) 72-hours stool output was 54.75± 12.92 g per kilogram in the racecadotril group and 152.50±37.64 g per kilogram in the placebo group (p<0.001). The number of purging is significantly reduced in the racecadotril group than the placebo group (11.95±2.41 Vs 14.85±1.95, p= 0.000) on third day of admission. The duration of hospital stay is significantly lower in the racecadotril group than the placebo group (73.30±23.44 vs. 177.30±25.8. p= 0.000) group. Racecadotril was well tolerated; only 3 patients taking racecadotril had adverse effects like vomiting and 2 patients had hypokalaemia and 3 patients in the placebo group developed vomiting and 1patient developed hypokalaemia which all are mild and transient.
Conclusion: In young children with acute watery diarrhea, racecadotril is an effective and safe treatment along with rehydration therapy.
DS (Child) H J 2020; 36(1) : 8-13
Constrictive Pericarditis Leading to Cardiac Cirrhosis: A Rare Cause of Chronic Liver Disease
Authors: Subha Nahid E , Akter Sharmin , Sabiha Aysha , Hasan Md Shariful , Bayes Farhana , Mazumder Wahiduzzaman 
Published: March 2021

Abstract not available
DS (Child) H J 2020; 36(1) : 71-74
Microwave Assisted Extraction of L-fenchone from Foeniculum vulgare Mill. in Hexane
Authors: Ansari Madeeha , Javad Sumera , Haider Azeem , Alam Muhammad Mohsin 
Published: March 2021

Medicinal plants produce natural chemicals either pure or in the form of mixture of compounds which are diverse in nature. These compounds show activities which are very important for human health such as antioxidant activity, antimicrobial effect, anti-helminths activity, anti-inflammation activity, immune system activation, decrease of platelet aggregation, treatment of diabetes and modulation of hormone metabolism and anticancer property. Demand of these natural compounds is increasing therefore it is needed to develop the more effective methods for extraction of these compounds. Foeniculum vulgare Mill. is one of the most commonly used medicinal plants used in cure of many diseases. In present study the experimental design was developed for the extraction of compounds specially “L-fenchone”, an essential part of fennel essential oils by Microwave Assisted Extraction (MAE) from seeds of F. vulgare. Extraction was done in hexane from different particle sizes (40μ and 80μ) of plant material at 600W of microwaves power in 1 and 5 mint. Gas chromatography mass spectroscopy (GCMS) was used for the quantification of L-fenchone. MAE was proved to be an efficient and rapid method of extraction from seeds of F. vulgare. Highest amount was extracted from 80μ, which was 183.33 mg per gram of plant sample. MAE consumed lesser energy by taking lesser time (5 minutes) for extraction. It proved to be cost effective technique as consumed lesser solvents and samples.
Preoperative Microbiomes and Intestinal Barrier Function Can Differentiate Prodromal Alzheimer’s Disease From Normal Neurocognition in Elderly Patients Scheduled to Undergo Orthopedic Surgery
Authors: Duan Mei , Liu Fangyan , Fu Huiqun , Lu Shibao , Wang Tianlong 
Published: March 2021

ObjectiveEmerging evidence links perturbations in the microbiome to neurodegeneration in amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD) and to surgical stress. In this study, we attempted to identify preoperative differences intestinal microbiota (IM) and barrier function between pAD [prodromal AD: Subjective cognitive decline (SCD) and aMCI] patients and normal neurocognition (NC) patients. Additionally, the potential associations between IM and barrier function, inflammation, and the clinical characteristics of pAD were evaluated.DesignEighty elderly patients scheduled to undergo orthopedic surgery were consecutively enrolled and grouped as NC, SCD, and aMCI following neuropsychological assessment. IM was determined by 16S rRNA MiSeq sequencing, and PICRUSt was used to predict functional shifts in IM. Furthermore, we investigated the association between IM and plasma claudin-1, occludin, LPS, systemic inflammatory cytokines, neuropsychological assessment, and clinical characteristics.ResultsThere was a lower Chao1 index in the SCD group (P = 0.004) and differences in beta diversity among the three groups (PCA: P = 0.026, PCoA: P= 0.004). The relative abundance of Bacteroidetes was higher in the SCD group (P = 0.016, P = 0.008), and Firmicutes were more enriched in the aMCI group than in the SCD group (P= 0.026). At the family level, the total abundance of Gram-negative bacteria was higher in the SCD group than in the aMCI group (P = 0.047), and the Christensenellaceae family was detected at lower levels in the SCD and aMCI groups than in the NC group (P= 0.039). At the genus level, the eleven short-chain fatty acid (SCFA)-producing bacteria exhibited differences among the three groups. PICRUSt analysis showed that the pathways involved in SCFA catabolism, biosynthesis, and adherent junctions were reduced in SCD patients, and lipid synthesis proteins were reduced in pAD patients. Meanwhile, elevated plasma LPS and CRP were observed in SCD patients, and higher plasma occludin in aMCI patients. The IM was correlated with plasma claudin-1, LPS, inflammatory factors, neuropsychological assessment, and clinical characteristics.ConclusionThe intestines of SCD and aMCI patients preoperatively exhibited IM dysbiosis and barrier dysfunction, and elevated plasma LPS and CRP were observed in SCD patients.
Serum miR-375 for Diagnostic and Prognostic Purposes in Medullary Thyroid Carcinoma
Authors: Censi Simona , Bertazza Loris , Piva Ilaria , Manso Jacopo , Benna Clara , Iacobone Maurizio , Mondin Alberto , Plebani Mario , Faggian Diego , Galuppini Francesca , Pennelli Gianmaria , Barollo Susi , Mian Caterina 
Published: March 2021

PurposeHaving previously demonstrated that tissue miR-375 expression in medullary thyroid carcinoma (MTC) tissues is linked to prognosis, the aim of this study was to assess the diagnostic and prognostic value of circulating miR-375 levels in MTC patients.MethodsA series of 68 patients with MTC was retrospectively retrieved and assessed in terms of their clinicopathological characteristics. MiR-375 levels were measured in all patients’ presurgical blood samples. Both serum and tissue levels were tested prior to surgery in a subgroup of 57 patients. Serum miR-375 levels were also measured in serum from 49 patients with non-C-cell thyroid nodular diseases (non-CTN), 14 patients with pheochromocytoma, and 19 healthy controls.ResultsCirculating miR-375 levels were 101 times higher in the serum of patients with MTC than in all other patients and controls, with no overlap (P &lt; 0.01). No correlation emerged between serum and tissue miR-375 levels. Serum miR-375 levels were higher in MTC patients with N0 than in those with N1 disease (P = 0.01), and also in patients who were biochemically cured than in those who were not (P = 0.02). In the whole series of patients and controls, calcitonin (CT) and serum miR-375 levels were correlated at diagnosis (R2 = 0.40, P &lt; 0.01), but in a U-shaped manner: a positive correlation was found with low CT levels, then the correlation turns negative as CT rises (in MTC patients). A negative correlation was indeed found in MTC patients between serum miR-375 and CT (R2 = −0.10, P = 0.01). On ROC curve analysis, a cut-off of 2.1 for serum miR-375 proved capable of distinguishing between MTC patients and the other patients and controls with a 92.6% sensitivity and a 97.6% specificity (AUC: 0.978, P &lt; 0.01).ConclusionsSerum miR-375 levels can serve as a marker in the diagnosis of MTC, with a remarkable specificity. Serum miR-375 also proved a novel marker of prognosis in this disease. Further in vitro experiments to corroborate our results are currently underway.
Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study
Authors: Yang Qilin , Zheng Jiezhao , Chen Weiyan , Chen Xiaohua , Wen Deliang , Chen Weixiao , Xiong Xuming , Zhang Zhenhui 
Published: March 2021

Background: Sepsis is a deadly disease worldwide. Effective treatment strategy of sepsis remains limited. There still was a controversial about association between preadmission metformin use and mortality in sepsis patients with diabetes. We aimed to assess sepsis-related mortality in patients with type 2 diabetes (T2DM) who were preadmission metformin and non-metformin users.Methods: The patients with sepsis and T2DM were included from Medical Information Mart for Intensive Care -III database. Outcome was 30-day mortality. We used multivariable Cox regression analyses to calculate adjusted hazard ratio (HR) with 95% CI.Results: We included 2,383 sepsis patients with T2DM (476 and 1,907 patients were preadmission metformin and non-metformin uses) between 2001 and 2012. The overall 30-day mortality was 20.1% (480/2,383); it was 21.9% (418/1,907), and 13.0% (62/476) for non-metformin and metformin users, respectively. After adjusted for potential confounders, we found that preadmission metformin use was associated with 39% lower of 30-day mortality (HR = 0.61, 95% CI: 0.46–0.81, p = 0.007). In sensitivity analyses, subgroups analyses, and propensity score matching, the results remain stable.Conclusions: Preadmission metformin use may be associated with reduced risk-adjusted mortality in patients with sepsis and T2DM. It is worthy to further investigate this association.
Low Serum 25-hydroxyvitamin D (Vitamin D) Level Is Associated With Susceptibility to COVID-19, Severity, and Mortality: A Systematic Review and Meta-Analysis
Authors: Akbar Mohammad Rizki , Wibowo Arief , Pranata Raymond , Setiabudiawan Budi 
Published: March 2021

Background: This systematic review and meta-analysis aimed to assess whether low serum 25-hydroxyvitamin D (25-OHD) level is associated with susceptibility to COVID-19, severity, and mortality related to COVID-19.Methods: Systematic literature searches of PubMed, Scopus, and Embase database up until 9 December 2020. We include published observational prospective and retrospective studies with information on 25-OHD that reported main/secondary outcome. Low serum 25-OHD refers to participants with serum 25-OHD level below a cut-off point ranging from 20 to 30 ng/mL. Other cut-off values were excluded to reduce heterogeneity. The main outcome was mortality defined as non-survivor/death. The secondary outcome was susceptibility and severe COVID-19.Results: There were 14 studies comprising of 999,179 participants. Low serum 25-OHD was associated with higher rate of COVID-19 infection compared to the control group (OR = 2.71 [1.72, 4.29], p &lt; 0.001; I2: 92.6%). Higher rate of severe COVID-19 was observed in patients with low serum 25-OHD (OR = 1.90 [1.24, 2.93], p = 0.003; I2: 55.3%), with a sensitivity of 83%, specificity of 39%, PLR of 1.4, NLR of 0.43, and DOR of 3. Low serum 25-OHD was associated with higher mortality (OR = 3.08 [1.35, 7.00], p = 0.011; I2: 80.3%), with a sensitivity of 85%, specificity of 35%, PLR of 1.3, NLR of 0.44, and DOR of 3. Meta-regression analysis showed that the association between low serum 25-OHD and mortality was affected by male gender (OR = 1.22 [1.08, 1.39], p = 0.002), diabetes (OR = 0.88 [0.79, 0.98], p = 0.019).Conclusion: Low serum 25-OHD level was associated with COVID-19 infection, severe presentation, and mortality.