bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dimensional Analysis of Atypical Functional Connectivity of Major Depression Disorder and Bipolar Disorder
Authors: Chen Heng , Lu Fengmei , Guo Xiaonan , Pang Yajing , He Changchun , Han Shaoqiang , Duan Xujun , Chen Huafu 
Published: July 2021

Abstract
Literatures have reported considerable heterogeneity with atypical functional connectivity (FC) pattern of psychiatric disorders. However, traditional statistical methods are hard to explore this heterogeneity pattern. We proposed a “brain dimension” method to describe the atypical FC patterns of major depressive disorder and bipolar disorder (BD). The approach was firstly applied to a simulation dataset. It was then utilized to a real resting-state functional magnetic resonance imaging dataset of 47 individuals with major depressive disorder, 32 individuals with BD, and 52 well matched health controls. Our method showed a better ability to extract the FC dimensions than traditional methods. The results of the real dataset revealed atypical FC dimensions for major depressive disorder and BD. Especially, an atypical FC dimension which exhibited decreased FC strength of thalamus and basal ganglia was found with higher severity level of individuals with BD than the ones with major depressive disorder. This study provided a novel “brain dimension” method to view the atypical FC patterns of major depressive disorder and BD and revealed shared and specific atypical FC patterns between major depressive disorder and BD.
Coronary embolism due to possible thrombosis of prosthetic aortic valve - the role of optical coherence tomography: case report
Authors: Kavaliauskaite Raminta , Otsuka Tatsuhiko , Ueki Yasushi , Räber Lorenz 
Published: July 2021

Abstract

Background
Coronary embolism is an important non-atherosclerotic cause of acute myocardial infarction (AMI) that requires an individualized diagnostic and therapeutic approach. Although certain angiographic criteria exist that render an embolic origin likely, uncertainty remains. Optical coherence tomography (OCT) is a high-resolution intracoronary imaging technology that enables visualization of thrombus and the underlying coronary vessel wall, which may be helpful to distinguish between an atherosclerotic and non-atherosclerotic origin of AMI.

Case summary
A 50-year-old male was admitted with ongoing chest pain. Eleven years ago, he underwent implantation of a mechanical aortic valve prosthesis due to degenerated bicuspid valve with normal coronaries on preoperative angiography. The electrocardiogram showed anterior ST-segment elevation. Emergent angiography revealed total occlusion of the proximal left anterior descending artery (LAD). Thrombus was aspirated along with administration of intravenous glycoprotein IIbIIIa inhibitor. Except the apical part of the LAD showing distal embolization, coronary flow was completely re-established with no evidence of significant atherosclerosis. Stents were not implanted on the basis of the OCT finding, which demonstrated at the site of occlusion a normal vessel wall without atherosclerosis that could explain an erosion or plaque rupture event. Transoesophageal echocardiography confirmed a floating structure in the left ventricular outflow tract, suggesting that an embolus originating from the prosthetic aortic valve obstructed the LAD. The international normalized ratio 2 days prior to presentation measured 1.9.

Discussion
This case illustrates the utility of OCT to rule out the atherosclerotic aetiology of myocardial infarction and to avoid unnecessary stenting.
First successful transcatheter valve-in-valve implantation into a failed mechanical prosthetic aortic valve facilitated by fracturing of the leaflets: a case report
Authors: Butter Christian , Kühnel Ralf-Uwe , Hölschermann Frank 
Published: July 2021

Abstract

Background
Degenerated and failed bioprosthetic cardiac valves can safely be treated with transcatheter valve-in-valve implantation in patients at high risk for reoperation. So far, non-functional mechanical valves must be treated with a surgical redo. Breaking the carbon leaflets before implanting a transcatheter valve into the remaining ring has never been described before.

Case summary
Here, we present the case of a 65-year-old male patient with severe heart failure, poor left ventricular function based on a fully immobile disc of his mechanical bileaflet aortic valve implanted 7 years ago. After the heart team declined to reoperate the patient due to his extremely high risk, we considered a transcatheter valve-in-valve implantation as the ultimate treatment approach. After successful interventional cracking of the leaflets in vitro, this approach, together with implanting a balloon-expandable transcatheter aortic valve replacement (TAVR) into the remaining ring, was performed under cerebral protection. The intervention resulted in a fully functional TAVR, improvement of heart function, and early discharge from the hospital.

Discussion
This case demonstrates the possibility to implant a transcatheter valve successfully into a non-functional mechanical bileaflet aortic prosthesis after fracturing the carbon discs while the brain is protected by a filter system. Critical steps of the procedure were identified. This new therapeutic approach might be offered to a limited patient cohort who is not eligible for a surgical redo.
Post-pubertal effects of the Alt-RAMEC/FM and RME/FM protocols for the early treatment of Class III malocclusion: a retrospective controlled study
Authors: Masucci Caterina , Franchi Lorenzo , Franceschi Debora , Pierleoni Felicita , Giuntini Veronica 
Published: July 2021

Summary

Objective
To assess the stability of the effects of the modified Alt-RAMEC and facial mask (FM) protocol at a post-pubertal observation.

Methods
Twenty-one Class III patients (11 males and 10 females, 6.5 ± 0.7 years) treated consecutively with the Alt-RAMEC/FM approach and presenting with lateral cephalograms taken before treatment (T1), after treatment (T2), and at post-pubertal observations (T3) were compared with 22 Class III patients (9 males and 13 females, 6.9 ± 1.2 years) treated with the rapid maxillary expansion (RME) and FM protocol and with 15 Class III untreated subjects (7 males and 8 females, 6.2 ± 2.2 years). At T3, all patients showed a post-pubertal skeletal maturation stage (CS4–CS6). Descriptive statistics and statistical comparisons between the three groups at T1 and for the T3–T1, T2–T1, and T3–T2 changes were assessed by means of the ANOVA or Kruskal–Wallis test.

Results
During the overall observation period, Alt-RAMEC/FM and RME/FM protocols produced statistically significant favourable effects when compared with the Control group (ANB + 2.8° and +2.2°, respectively; Wits appraisal +4.4 mm and +2.7 mm, respectively). No statistically significant differences were found between the outcomes of the Alt-RAMEC/FM and RME/FM protocols neither at the post-pubertal or short-term observations.

Limitations
Retrospective study and the comparison with an historical control sample of subjects with untreated Class III malocclusion.

Conclusions
The Alt-RAMEC/FM protocol cannot be recommended as the approach of choice for the therapy of Class III dentoskeletal disharmony in very young subjects compared to the conventional RME/FM protocol.
The biological sex lens on early orthopaedic treatment duration and outcomes in Class III orthodontic patients: a systematic review
Authors: Arqub Sarah Abu , Al-Zubi Khadijeh , Iverson Marissa G , Ioannidou Effie , Uribe Flavio 
Published: July 2021

Summary

Background
Treatment outcomes for Class III orthopaedic treatment are highly unpredictable and dependent on the timing of interception, age, and biological sex.

Objective
This systematic review aimed to assess the effects of sex dimorphism on outcomes and duration of orthopaedic treatment for Class III malocclusion in young children.

Search methods
Unrestricted search in six electronic databases until May 2021 was conducted. Supplemented by search in resources for published, unpublished literature, and ongoing trials.

Selection criteria
Randomized and non-randomized controlled trials reporting the use of Class III growth modification appliances, with baseline and outcome data for both sexes, were included.

Data collection and analysis
Study selection and data extraction were performed blindly and in duplicate by two reviewers. ROBINS-I, Cochrane Risk of Bias, and GRADE tools were used for certainty assessment.

Results
A total of 2429 records were screened. Four trials fulfilled the inclusion criteria, one was a randomized clinical trial (RCT) comparing facemask and facemask with mini-screw. Two clinical trials evaluated the effects of facemask appliance, one had a control group, another was prospective non-controlled. One compared the effects of the maxillary protraction bow appliance to a no treatment control. Two of the clinical trials were appraised as low and one was appraised as high risk of bias. The overall certainty of the available evidence was assessed as moderate. There was significant clinical heterogeneity in terms of methodology, type of intervention, and the measured outcomes, precluding a meta-analysis.

Conclusions
Minimal variations in sagittal, vertical, and dentoalveolar post-treatment cephalometric changes were reported between sexes. The available evidence is unclear to support these variations. Long-term-powered RCTs assessing cephalometric outcomes between sexes until the end of growth spurt and without pooling are not available, therefore, much needed.

Registration
PROSPERO database number CRD42020185797.
Effect of remote monitoring on clinical outcomes in European heart failure patients with an implantable cardioverter-defibrillator: secondary results of the REMOTE-CIED randomized trial
Authors: Chiu Cheyenne S L , Timmermans Ivy , Versteeg Henneke , Zitron Edgar , Mabo Philippe , Pedersen Susanne S , Meine Mathias ,   for the REMOTE-CIED Trial Investigators
Published: July 2021

Abstract

Aims
Remote patient monitoring (RPM) systems offer a promising alternative to conventional In-Clinic check-ups, hereby reducing unnecessary clinic visits. Especially with the rise of the COVID-19 pandemic, this reduction is of paramount importance. Regarding the association between RPM and clinical outcomes, findings of previous studies have been inconsistent. The aim of this study is to elucidate the effect of partly substituting In-Clinic visits by RPM on clinical outcomes in implantable cardioverter-defibrillator (ICD) patients.

Methods and results
The study included 595 heart failure patients (LVEF ≤35%; NYHA Class II/III) implanted with an ICD compatible with the Boston Scientific LATITUDE™ system. Participants were randomized to RPM plus an annual In-Clinic visit or 3–6 months In-Clinic check-ups alone. The investigated endpoints after 2 years of follow-up included a composite of all-cause mortality and cardiac hospitalization, mortality and cardiac hospitalization as independent endpoints and ICD therapy. The incidence of mortality and hospitalization did not differ significantly as independent, nor as composite endpoint between the RPM and In-Clinic group (all Ps &lt;0.05). The results were similar regarding ICD therapy, except for appropriate ICD therapy (odds ratio 0.50; 95% confidence interval 0.26–0.98; P = 0.04). Exploratory subgroup analyses indicated that the effect of RPM differs between patients with specific characteristics, i.e. ≥60 years and permanent atrial fibrillation (all Ps &lt; 0.05).

Conclusion
RPM is non-inferior to conventional In-Clinic visits regarding clinical outcomes. Routine In-Clinic follow-up may partly be substituted by RPM without jeopardizing safety and efficiency, and thus reducing unnecessary In-Clinic visits.

ClinicalTrials.gov identifier
NCT01691586.
Simultaneous gravity measurements using two superconducting gravimeters to observe temporal gravity changes below the nm s−2 level: ocean tide loading differences at different distances from the coast
Authors: Goto Hiroki , Sugihara Mituhiko , Nishi Yuji , Ikeda Hiroshi 
Published: July 2021

SUMMARY
Gravity monitoring might require observation of temporal changes of gravity below the nanometre per second squared (nm s−2) level, which can be achieved by precise isolation of the signal of interest from all other disturbing effects. One method of signal isolation is elimination of disturbing effects by taking the difference between gravity changes measured simultaneously using two gravimeters installed close together. Herein, we describe differences in temporal gravity changes below the nm s−2 level in the tidal frequency bands as observed through simultaneous measurements taken with three superconducting gravimeters (SGs) located 80, 93 and 94 m from the coastline in Tomakomai, Hokkaido, northern Japan. Those changes are consistent with differences in ocean tide loading effects on gravity at the SG locations computed using the software package GOTIC2, which uses a highly accurate land–sea boundary and ocean tide model near our site. The observed ocean tide loading differences were found to result from Newtonian attraction of the ocean tide mass within an angular distance of 0.003° from the SG locations. This result suggests that coastal observations of differential tidal gravity variations at different distances from the coast help to validate ocean tide loading computation models in the immediate vicinity of the SG stations. This method enables observation of non-periodic gravity changes occurring below the nm s−2 level over a few hours. Its salient benefit is that rapid and simple observation can be achieved without long-term continuous measurements, which is necessary for observing that level of gravity change with only one SG.
Back-propagating rupture evolution within a curved slab during the 2019Mw 8.0 Peru intraslab earthquake
Authors: Hu Yaping , Yagi Yuji , Okuwaki Ryo , Shimizu Kousuke 
Published: July 2021

SUMMARYThe 26 May 2019 MW 8.0 Peru intraslab earthquake ruptured the subducting Nazca Plate where the dip angle of the slab increases sharply and the strike angle rotates clockwise from the epicentre to north. To obtain a detailed seismic source model of the 2019 Peru earthquake, including not only the rupture evolution but also the spatiotemporal distribution of focal mechanisms, we performed comprehensive seismic waveform analyses using both a newly developed flexible finite-fault teleseismic waveform inversion method and a back-projection method. The source model revealed a complex rupture process involving a back-propagating rupture. The initial rupture propagated downdip from the hypocentre, then unilaterally northward along the strike of the slab. Following a large slip occurring ∼50–100 km north of the hypocentre, the rupture propagated bilaterally both further northward and back southward. The spatial distribution of focal mechanisms shows that the direction of T-axis azimuth gradually rotated clockwise from the epicentre northward, corresponding to the clockwise rotation of the strike of the subducting Nazca Plate, and the large-slip area corresponds to the high-curvature area of the slab iso-depth lines. Our results show that the complex rupture process, including the focal-mechanism transition, of the Peru earthquake was related to the slab geometry of the subducting Nazca Plate.
Influential parameters on 3-D synthetic ground motions in a sedimentary basin derived from global sensitivity analysis
Authors: De Martin F , Chaljub E , Thierry P , Sochala P , Dupros F , Maufroy E , Hadri B , Benaichouche A , Hollender F 
Published: July 2021

SUMMARYWhich physical parameters are the most influential when predicting earthquake ground motions in a 3-D sedimentary basin? We answer quantitatively by doing a global sensitivity analysis of two quantities of interest: the peak ground motions (PGMs) and a time–frequency representation (the S transform) of ground motions resulting from the synthetic anelastic responses of the EUROSEISTEST. This domain of interest is modeled by two layers with uncertain depth-dependent mechanical properties and is illuminated by a plane S-wave propagating vertically upward in an uncertain homogeneous elastic bedrock. The global sensitivity analysis is conducted on 800+ physics-based simulations of the EUROSEISTEST requiring 8+ million core-hours (i.e. ≈ 900 yr of mono-core computation). The analysis of the PGMs at the free surface displays the spatial influence of the uncertain input parameters over the entire basin scale, while the analysis of the time–frequency representation shows their influence at a specific location inside the basin. The global sensitivity analysis done on the PGMs points out that their most influential parameter in the middle of the basin is the quality factor QS (it controls up to 80 per cent of the PGMs in certain locations where the sediments thickness is larger than 200 m). On the other hand, the geological layering configuration (here represented by the depth of a geological interface controlling the geological layering) strongly influences the PGMs close to the basin edges, up to 90 per cent. We also found that the shear wave velocity at the free surface of the basin and the one of the bedrock underlying the basin are to be considered on an equal footing, both influencing the PGMs in the middle of the basin and close to its edges. We highlight that the bedrock to basin amplification of the PGMs shows a clear increase with respect to the thickness of the sediments, but this amplification saturates from 200 m of sediments around the value of three and is frequency dependent. This PGMs amplification starts from about one tenth of the mean S-wavelength propagating in the basin. The global sensitivity analysis done on the S transform of the ground motions shows that (i) the own effect of the parameters fully controls the first S-wave train and mostly controls the direct arrival of the basin-induced surfaces waves, (ii) the quality factor QS controls 40–60 per cent of the decay of amplitude of coda waves, the remaining part being mainly controlled by interaction effects due to the coupling effect of several parameters and (iii) the interaction effects between the parameters increases with time, suggesting under the hypotheses of our study that the own effects control the ballistic wave propagation while the interaction effects control the diffusive wave propagation.
Optimal inspection policy for a second-hand product with a two-dimensional warranty
Authors: Heydari Majeed 
Published: July 2021

Abstract
This paper studies the situation in which a manufacturer acts as a dealer and buys a second-hand product from one customer and sells it with a two-dimensional warranty to another customer. The manufacturer plans to inspect the product during the warranty period to identify and remove hidden defects and hence prevent failure as well as their corresponding cost. We describe a two-dimensional delay time model in which the customer’s usage rate affects both the time to defect and delay time. This concept is then used to derive a new class of failure models, namely, the two-dimensional and two-stage failure model. The number and time of inspections are determined to minimize the service cost during the warranty period under periodic and sequential inspection policies. Our approach is illustrated using an example from the automobile industry. A sensitivity analysis evaluates the effect of changes in the parameters of the model. Results indicate that the proposed model can aid the decision-making of a manufacturer, particularly in relation to the effect of customers’ usage and the effect of inspection upon the service cost during the warranty period.
On the Asymptotic Behavior of Solutions to the Vlasov–Poisson System
Authors: Ionescu Alexandru D , Pausader Benoit , Wang Xuecheng , Widmayer Klaus 
Published: July 2021

AbstractWe prove small data modified scattering for the Vlasov–Poisson system in dimension $d=3$, using a method inspired from dispersive analysis. In particular, we identify a simple asymptotic dynamics related to the scattering mass.
Liberal Ideology and Foreign Opinion on China
Authors: Chu Jonathan A 
Published: July 2021

Abstract
Why do autocratic powers like China evoke negative attitudes from the citizens of some countries but not from others? Factors like economic and security threat are of course part of the answer, but this study finds that ideational factors exert a distinct effect. Drawing from social theories of the democratic peace and international relations more broadly, it observes that governments and their citizens form communities along ideological lines, which most prominently includes differences in liberal democracy. This argument implies that people within the liberal community tend to view authoritarian powers like China as having a harmful influence on the world. Furthermore, democratic citizens will evaluate China from the standpoint of liberal democratic norms. Because liberal norms are not just about having multiparty, electoral institutions, people's opinions on China could vary even if its single-party political system does not change. Three empirical studies drawing from cross-national observational data, two original survey experiment, and a difference-in-differences analysis of historical polls confirm that liberal democracy affects foreign perceptions about China. The findings advance debates about soft power, democracy and public opinion, and the role of ideology in international society.
ESBL-positive Escherichia coli and Klebsiella pneumoniae isolates from across Canada: CANWARD surveillance study, 2007–18
Authors: Karlowsky James A , Walkty Andrew , Golden Alyssa R , Baxter Melanie R , Denisuik Andrew J , McCracken Melissa , Mulvey Michael R , Adam Heather J , Zhanel George G 
Published: July 2021

Abstract

Objectives
ESBL-producing Escherichia coli and Klebsiella pneumoniae are pathogens of increasing importance in Canada and elsewhere in the world. The purpose of this study was to phenotypically and molecularly characterize ESBL-producing E. coli and K. pneumoniae clinical isolates obtained from patients attending Canadian hospitals over a 12 year period.

Methods
Isolates were collected between January 2007 and December 2018 as part of an ongoing national surveillance study (CANWARD). ESBL production was confirmed using the CLSI (M100) phenotypic method. Susceptibility testing was carried out using custom broth microdilution panels, and all isolates underwent WGS.

Results
In total, 671 E. coli and 141 K. pneumoniae were confirmed to be ESBL producers. The annual proportion of ESBL-producing isolates increased for both E. coli (from 3.3% in 2007 to 11.2% in 2018; P &lt; 0.0001) and K. pneumoniae (from 1.3% in 2007 to 9.3% in 2018; P &lt; 0.0001). The most frequent STs were ST131 for E. coli [62.4% (419/671) of isolates] and ST11 [7.8% (11/141)] and ST147 [7.8% (11/141)] for K. pneumoniae. Overall, 97.2% of ESBL-producing E. coli and K. pneumoniae isolates were MDR. blaCTX-M-15 predominated in both ESBL-producing E. coli (62.3% of isolates) and ESBL-producing K. pneumoniae (48.9% of isolates).

Conclusions
The proportion of ESBL-producing E. coli, especially ST131, and K. pneumoniae, especially ST11 and ST147, in Canada increased significantly from 2007 to 2018. Continued prospective surveillance of these evolving MDR and at times XDR pathogens is imperative.