bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liraglutide vs. Lifestyle Intervention in Obesity Treatment: Pros and Cons
Authors: Mckenzie Simone , Mostafa Jihan 
Published: August 2021

The increasing prevalence of obesity continue to trigger a cascade of other non-communicable medical conditions and further cripple healthcare financial budgets worldwide. This preventable chronic disease is a global public health concern and has been the center of past, present and future research. As an adjunct to lifestyle intervention, the Food and Drug Administration (FDA) has currently approved five anti-obesity medications. However, skepticism surrounding the prescription of medication is presented based on historic concerns of previously withdrawn medication.
Liraglutide is among the newly approved anti-obesity medications and has shown favorable weight loss results. The choice of treatment requires a selective determination based on the specific patient population, existing chronic condition(s) and individual preferences.
The goal of this review is to highlight the advantages and disadvantages of liraglutide use compared to lifestyle intervention in treating obesity. This would help individuals make informed decisions in choosing the most suitable option for treating obesity.
It can be concluded that there is no single-handed approach to combat obesity. Regardless of the chosen option, individuals need to be consistent with behavioral changes and exercise in order to effectively treat and possibly eradicate this global epidemic.
El Picante a la Tacnea como eje social.
Authors: Osorio Soto Gary Martín 
Published: August 2021

En el presente artículo, se ha propuesto la aproximación analítica sobre historia y arqueología sobre “Picante a la Tacneña”, una cocina fundamental en la identidad cultural tacna. El sincretismo culinario es una reflexión sobre la participación múltiple del agente en el proceso sociocultural e histórico en la adopción, mestizo y desarrollo de un plato culinario. Comprender el proceso sociocultural de este plato permitirá profundizar y mejorar la información sobre el origen, generar desmentir los mitos sobre el origen entre un período realizado sobre la ocupación chilena en Tacna y Arica (1880-1929). Versión de lo que es una premisa falsa, y continuamente bruta e incomprendida. Sin embargo, la base gastronómica, el concepto base del “Picante a la Tacneña” tiene su origen en los siglos XVI y XVII.
El presente artículo promueve el análisis histórico y arqueológico del “Picante a la Tacneña”, comida fundamental de la identidad cultural de Tacna. El sincretismo culinario refleja la participación de múltiples agentes y procesos socio - históricos en la adopción, mestizaje y desarrollo de este plato. El entendimiento sociocultural de este plato, permitió brindar mayores luces sobre su origen, desmontando los mitos de su “Origen” en el período de la ocupación de Tacna y Arica por parte de Chile (1880-1929). Versión el cual ha sido largamente difundida y mal interpretada. Sin embargo, la base gastronómica, se remonta entre los Siglos XVI al XVII, con lo cual, la discusión a plantear es la singularidad y composición única del plato, en un entorno de diversidad geográfica,
Palabras clave: Gastronomía; Conquista; Tacna, Pe
Valor do tempo e escolha modal no transporte de carga: estudo de caso de Rio de Janeiro e Rio Grande do Sul
Authors: Larranaga Ana Margarita , De Souza Felipe Lobo Umbelino , Arellana Julian , Senna Luiz Afonso 
Published: August 2021

O presente artigo analisa a estrutura de decisão dos usuários embarcadores de transporte de carga de dois estados brasileiros: Rio Grande do Sul (RS) e Rio de Janeiro (RJ). Modelos de escolha discreta são estimados para analisar a escolha modal de embarcadores de carga a partir de dados de Preferência Declarada. Os resultados evidenciam e quantificam o impacto nas preferências das empresas embarcadoras de carga de minimizar tempos, custos e atraso nos envios de mercadoria. Adicionalmente, é quantificado o impacto de características de confiabilidade, disponibilidade do modo e tipo de serviço na escolha modal. Os resultados mostram a complementariedade dos dados de RJ e RS na estimação dos modelos. Características de custo são percebidas de forma similar por embarcadores de carga de ambos os estados, entretanto características de confiabilidade e de tempo de viagem mostraram ser percebidas de forma diferente. O valor do tempo estimado para RJ foi de R$/t. h 7,43 e para RS de R$/t. h 2,49.
Association of Terry Nails With Liver Cirrhosis
Authors: Sack Jordan S. , Liu Anne F. , Gray Meagan , Roat James , Zucker Stephen D. 
Published: August 2021

INTRODUCTION:
We looked at the association between Terry nails and liver cirrhosis in an ambulatory population from hepatology and gastroenterology clinics.

METHODS:
We prospectively investigated the prevalence and determinants of Terry nails in 1,000 consecutive patients from hepatology and gastroenterology clinics at 2 institutions between May 2016 and February 2020.

RESULTS:
A total of 117 subjects manifested Terry nails, with a 25.6% prevalence in patients with cirrhosis. When adjusted for age, heart failure, diabetes mellitus type 2, and chronic liver disease, cirrhosis was the only significant correlate (odds ratio 5.7 [95% confidence interval 3.3–9.8]), irrespective of liver disease etiology, with a strong association with hepatic fibrosis stage (P < 0.0001).

DISCUSSION:
Sensitivity and specificity of Terry nails for cirrhosis (25.8%, 92.7%) was similar to palmar erythema but less than spider angioma.
Komplikasi Multi Organ pada Pasien yang Menjalani Operasi Double Valve Replacement
Authors: Karseno Iradewi , Sudjud Reza 
Published: August 2021

Latar Belakang: Penggantian lebih dari satu katup jantung digolongkan sebagai operasi risiko tinggi dengan risiko komplikasi yang lebih tinggi dibandingkan dengan operasi penggantian satu katup jantung.Kasus: Seorang wanita usia 35 tahun dengan stenosis katup aorta berat, regurgitasi katup aorta moderat dan stenosis katup mitral berat disertai atrial fibrilasi menjalani operasi double-valve replacement. Komplikasi yang ditemukan di intensive care unit (ICU) berupa perdarahan yang signifikan, fibrilasi atrial, cedera ginjal akut dan perdarahan intrakranial.Pembahasan: Komplikasi yang mungkin ditemukan setelah penggantian dua katup jantung meliputi koagulopati, cedera ginjal akut, aritmia dan gangguan serebrovaskular. Koagulopati dapat menyebabkan perdarahan yang signifikan dan instabilitas hemodinamik sehingga harus diberikan tatalaksana yang tepat. Aritmia dapat disebabkan oleh imbalans elektrolit. Cedera ginjal akut sering ditemukan pascaoperasi jantung terbuka dan sebaiknya dilakukan hemodialisis sesegera mungkin. Tatalaksana gangguan serebrovaskular dapat bersifat konservatif atau operasi. Keputusan tatalaksana gangguan serebrovaskular harus disesuaikan menurut kondisi klinis pasien.Kesimpulan: Deteksi dini dan tatalaksana yang cepat dan tepat sangatlah penting untuk menghindari morbiditas dan mortalitas pascaoperasi yang signifikan.
Analisis Faktor Risiko terhadap Lama Perawatan Pasien Sepsis yang Meninggal di Ruang Perawatan Intensif RSUD Dr. Soetomo Surabaya
Authors: Hatman Fajra Arif , Semedi Bambang Pujo , Budiono Budiono 
Published: August 2021

Latar Belakang: Sepsis disebabkan oleh ketidakseimbangan respons tubuh terhadap infeksi dan dapat mengakibatkan komplikasi yang berbahaya. Komplikasi yang ditimbulkan bervariasi, salah satu yang paling sering adalah disfungsi organ yang dapat dinilai melalui skor sequential organ failure assessment (SOFA). Sepsis masih menjadi masalah kesehatan karena sulitnya pengobatan dan lama perawatan yang lama sehingga menyebabkan mortalitas yang tinggi. Sepsis memiliki berbagai penyebab di antaranya pneumonia yang diketahui menjadi salah satu penyebab infeksi terbanyak pada sepsis. Selain itu, mikroorganisme juga menjadi salah satu penyebab infeksi terbanyak di ruang perawatan intensif. Pemeriksaan laboratorium memiliki hasil yang buruk pada banyak pasien sepsis seperti anemia dan leukositosis.Tujuan: Tujuan penelitian ini untuk menganalisis faktor risiko meliputi riwayat penyakit, riwayat konsumsi obat, diagnosis masuk, dan jumlah alat medis invasif terhadap lama perawatan dan mengetahui karakteristik pasien sepsis yang meninggal.Metode: Penelitian ini merupakan penelitian observasional analitik dengan menggunakan data rekam medis 42 pasien sepsis yang meninggal di ruang perawatan intensif RSUD Dr. Soetomo Surabaya. Data dideskripsikan dan dianalisis menggunakan software SPSS 26.Hasil: Terdapat 18 (42,86%) laki-laki dan 24 (57,14%) perempuan dengan rata-rata usia 55,98 + 15,411. Didapatkan median skor SOFA 7,5 (3–15) dengan sistem respirasi menjadi tempat infeksi terbanyak (50%). Pemeriksaan laboratorium menunjukkan banyak pasien sepsis mengalami anemia (66,67%) dan leukositosis (59,52%). Acinetobacter baumannii (26,08%) sebagai mikroorganisme yang paling banyak ditemukan. Hasil penelitian ditemukan hanya diagnosis masuk yang memiliki hubungan dengan lama perawatan (P = 0,05). Di sisi lain tidak ditemukan faktor risiko yang berpengaruh terhadap lama perawatan >5 hari (P > 0,05).Kesimpulan: Diagnosis masuk memperpanjang lama perawatan. Tidak ada faktor risiko yang berpengaruh terhadap durasi perawatan >5 hari. Karakteristik pasien secara umum memiliki kondisi medis yang buruk.
Analysis On Village Readiness In The Acceleration Of Open Defecation Free Achievement Status Based On Stimulus, Organism, And Response Approach
Authors: Rosanna Siti Farihah , Ma'ruf Khabib Fadlilatul , Aditya Yogi , Nurika Globila , Wikurendra Edza Aria 
Published: August 2021

Introduction: Open Defecation Free (ODF) is a condition in the community that has carried out total sanitation and does no more Open Defecation (OD). Dukuh Village was chosen as the research location because it was a village with the highest OD in Ngadiluwih, Kediri. This high rate of OD is caused by a lack of public awareness about the importance of sanitation. This research was conducted to analyze the village readiness to accelerate ODF status in Dukuh Village.Methods: This study was done in a qualitative method with a single holistic case study design using Stimulus-Organism-Response theory. The key informants of this study were five persons:1) the Head of Dukuh Village, 2) the environmental health officer of Wonorejo Community Health Center, 3) Dukuh Village community leader and 4) the community representatives who still defecated, and 5) no more defecated in an open area after triggering activities. They were selected purposively. Data were collected through in-depth interviews, Focus Group Discussion, and documents review. Data analysis was done through the Spradley model, scoring and categorizing village readiness using the scales of Aydin and Tasci.Results: Five main problems were the lack of funds for the ODF program, poor socialization, low Clean and Healthy Behavior, lack of roles from community leaders, and limited land for latrine construction. Based on the analysis of village readiness in achieving the ODF program using the Aydin & Tasci scale, the obtained score was 2.1. This score indicated that Dukuh Village was not ready yet and a lot of system improvements[h1] were needed.Conclusion: Dukuh Village was not ready yet for the ODF program and need a lot of system improvements. It was recommended to make village policies, create working groups, and maximizing socialization.
Microplastic Pollution in Waters and its Impact on Health and Environment in Indonesia: A Review
Authors: Basri K Sarinah , K Basri , Syaputra Eko Maulana , Handayani Sri 
Published: August 2021

Introduction: Microplastics have become a pollution problem that has received worldwide attention. Microplastics in the water impact the environment and health, especially in Indonesia, which is the second-largest plastic waste contributor in the world. This literature study aims to determine the distribution of microplastics pollution in waters and its impact on health and the environment in Indonesia.Methods: The literature search on papers from 2010-2021 through Google Scholar, Pubmed, ScienceDirect, and ProQuest, with the keywords of ‘Microplastics’, ‘Indonesia’, ‘aquatic’, ‘environment’ found 477 articles. Then, after the exclusion of duplicate articles, and other inclusion criteria, the final review was done on 42 articles. PRISMA guidelines were used for reviewing the procedure.Results: Most microplastic research was conducted in Java Island, which is dominated by rivers and beaches. Based on the source, microplastics came from domestic waste, tourism, and fishing activities. The most common forms found were black and blue fibers from fishing lines, nets, and clothing fibers of various sizes. The type of polymer identified is polyethylene plastic. Microplastics impacted tourist destinations, marine ecosystems through the food chain, and also humans who consume seafood.Conclusion: Microplastics are found in the Indonesian marine environment. Humans can consume seafood contaminated with microplastics, which will have an impact on health. Therefore, a health risk assessment should be done to provide information for taking environmental management efforts.
A case of common variable immune deficiency with lung disease–not just bronchiectasis
Authors: Polakow Farkash Sharon , Ehrlich Shai , Steuer Guy , Yacobovich Joanne , Diamant Nir , Marcus Nufar 
Published: August 2021

Introduction: Common Variable Immune Deficiency (CVID) is the most prevalent form of severe antibody deficiency in children and adults. Most patients suffer recurrent, mainly sinopulmonary, infections. Despite adequate IVIG replacement therapy, chronic lung disease continues to be a main cause of morbidity and mortality. The term granulomatous-lymphocytic interstitial lung disease (GLILD) is frequently used to describe interstitial lung disease associated with immune dysregulation in primary antibody deficiency, such as CVID. Aim: To describe the case of a 10-year-old male with CVID who developed GLILD and his response to treatment with Rituximab. Discussion: Our patient is a young male with CVID and no genetic diagnosis, whose lung functions and general condition continued to deteriorate despite adequate intravenous immunoglobulin replacement therapy and mycophenolate mofetil treatment. After the diagnosis of GLILD, we initiated treatment with a 4-dose weekly course of Rituximab with prompt resolution of his interstitial disease. Although GLILD is a well described condition that accompanies CVID as a manifestation of immune dysregulation, it is still under recognized, especially in the pediatric population. Among experts, there is little uniformity when it comes to diagnostic and treatment approaches. Recent studies showed improved outcomes when using combination therapy with Rituximab, such as in our patient. Statement of Novelty: We shed light on GLILD, an important condition that accompanies CVID, and demonstrate an excellent response to the steroid sparing agent Rituximab. This is a crucial aspect when considering therapeutic choices for the pediatric population.
Reassessing Passion and Perseverance as Dimensions of Individual Entrepreneurial Orientation: A Conceptual and Empirical Investigation into Theory and Measurement
Authors: Howard Matt C. , Floyd Andrea 
Published: August 2021

Abstract
Santos, G., C. S. Marques, and J. J. Ferreira. 2020. “Passion and Perseverance as Two New Dimensions of an Individual Entrepreneurial Orientation Scale.” Journal of Business Research 112: 190–9 proposed a five-dimensional conceptualization of individual entrepreneurial orientation (IEO), but more evidence is needed before authors can reliably apply their conceptualization and operationalization. We provide a theoretical critique of their conceptualization and continue their scale development process. Four of five dimensions converged with other scales of the same constructs, but their passion dimension did not. The factor structure and predictive validity evidence also suggested that passion should not be included within the scope of IEO, and we assert that Santos et al.’s conceptualization of IEO is better represented with a hierarchical structure. Proactiveness and perseverance as well as risk-taking and innovativeness load onto two separate second-order factors, and these two second-order factors load onto the broader factor of IEO. We suggest that the construct measured by Santos et al.’s passion dimension may instead be a mediator between IEO and entrepreneurial outcomes, and we provide further insights into the measurement of IEO.
Convergence analysis of online learning algorithm with two-stage step size
Authors: Nie Weilin , Wang Cheng 
Published: August 2021

Abstract
Online learning is a classical algorithm for optimization problems. Due to its low computational cost, it has been widely used in many aspects of machine learning and statistical learning. Its convergence performance depends heavily on the step size. In this paper, a two-stage step size is proposed for the unregularized online learning algorithm, based on reproducing Kernels. Theoretically, we prove that, such an algorithm can achieve a nearly min–max convergence rate, up to some logarithmic term, without any capacity condition.
3 W average-power high-order mode pulse in dissipative soliton resonance mode-locked fiber laser
Authors: Wang Longtao , Xu Jiangtao , Lu Jiafeng , Teng Linping , Luo Zhengqian , Pang Fufei , Zeng Xianglong 
Published: August 2021

AbstractRecently high-order modes (HOMs) lasers have been extensively investigated due to their potential applications in mode-division multiplexing. In this paper, we present two schemes of generating HOMs from the mode-locked fiber lasers (MLFLs) in the dissipative soliton resonance (DSR) regime. Watt-level HOM outputs are implemented through intra-cavity mode conversion. 3 W average-power HOMs with an efficiency slope of 25% can be obtained based on an MLFL in the DSR regime, which is achieved by incorporating a long-period fiber grating (LPFG) and a dual-resonant acoustically induced fiber grating (AIFG), respectively. Their different spectrum responses enable flexible mode conversion in the MLFLs. Both fiber mode converters are exploited to show their robust capability of efficient mode manipulation. The MLFL with an LPFG inserted in the cavity can achieve wide-bandwidth intra-cavity optical vortex beams (OVBs) near the dispersion turning around point because of the pulses of the fundamental mode and high-order vortex eigenmodes oscillating in the cavity with the same group velocity to form spatiotemporal mode locking. The MLFL based on a dual-resonant AIFG can perform the function of fast switching (∼0.3 ms) in LP01, LP11a, and LP11bmodes with a high modal purity of 96%. These different modes with high-energy pulses can be flexibly switched with programmable radio frequency modulation. Furthermore, a quarter-wave plate and a polarizer are employed at the output of fiber laser to realize the controllability of the mode field, which is possible to generate a controllable mode field of OVBs based on the first-order Poincaré sphere. This control method can be integrated with the MLFLs to extend the flexibility of high-power HOMs generation.
Crystal structure of (4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane-κ
8
N
2, O
6) potassium cyclopentadienide, [K([2.2.2]crypt)]Cp, C23H41KN2O6
Authors: Fischer Christina , Klein Wilhelm , Fässler Thomas F. 
Published: August 2021

Abstract
C23H41KN2O6, monoclinic, P21/c (no. 14), a = 10.9817(6) Å, b = 23.8330(15) Å, c = 9.7379(7) Å, β = 94.705(5)°, V = 2540.1(3) Å3, Z = 4, R

gt
(F) = 0.0327, wR
ref(F
2) = 0.0682, T = 120 K.
Sexuality and Gender Diversity in the Liberal Catholic Discourse in Poland in the Pastoral Perspective
Authors: Laddach Agnieszka 
Published: August 2021

Abstract
One of the most important questions in the Roman Catholic Church is the question of sexual and gender diversity. Therefore, the article presents the results of qualitative and quantitative content analysis of the Catholic sociocultural periodical Więź (Bond) from 2007 to 2020, which is the leading forum for liberal Catholic debates in Poland. The goal was to analyze the period’s narration toward current Church’s instructions on sexuality and gender diversity. Five dominant postulates were identified in Więź: (1) a discussion about people with the need to revise their or the Church’s narration on and experience of sex and gender; (2) a reevaluation of the significance and consequence of sexual revolution in Poland; (3) an organization of the understanding of body, sex, sexuality, and gender; (4) a promotion of the idea of encounter; and (5) a settlement of cases of sexual abuse in the Church. The article concludes that the presence of social dialogue on sexuality and gender diversity in the current pastoral approach of the Church in Poland requires a suspension of moral judgment and an openness from Church with a strong traditional, and rigid viewpoint to better understand the difficult spiritual and social situation of people who live contrary to the moral teachings of the Church or whose views go against these teachings.
Japanese orthographic complexity and speech duration in a reading task
Authors: Grippando Shannon 
Published: August 2021

Abstract
The number of letters in a word’s orthographic form can affect speech duration. Previous research in this area has been limited to studies of languages with alphabets. The current study expands upon this previous research by investigating effects on speech duration from units of orthographic complexity potentially analogous to letter length in Japanese, a language with a logography. In a modified version of a reading task used in one of the prior studies, native Japanese-speaking participants were audio-recorded reading pairs of homophonous words that varied by: 1) number of pen strokes in a single character; or 2) number of whole characters in their orthographic forms. Two-character words were produced significantly longer than one-character words. No significant effect was found from pen strokes on speech duration. These results are presented as evidence that the orthographic duration effect observed in previous studies is not limited to languages with alphabetic writing systems.
Survey Methodology for a Collection of Technical Drawings
Authors: Natsikou Aggeliki , Tsantiri Konstantina , Zervos Spiros 
Published: August 2021

Abstract
The YAMP (Projects and Specifications Archive Department) historical collection is part of the collections of technical drawings owned by the Historical Archive of Athens Water Supply and Sewerage Company (EYDAP S.A.). The survey of the collection, which is presented here, was commissioned by the Company to the Department of Archival, Library & Information Studies, University of West Attica, Greece. The objectives of the survey were the documentation of the condition of the collection, the determination of the technical specifications, and the cost estimation for its conservation. Several aspects of the survey methodology are presented, mainly the documentation step, which was planned to collect all the essential data, and the process of the cost estimation. Automation and parameterization of the calculations necessary for the documentation and the cost estimation are discussed in detail. The results of the survey and the recommended best practices for the optimization of the management of the collection are briefly outlined.