bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on multi-sensor information fusion and intelligent optimization algorithm and related topics of mobile robots
Authors: Guo Yuan , Fang Xiaoyan , Dong Zhenbiao , Mi Honglin 
Published: November 2021

AbstractResearch on mobile robots began in the late 1960s. Mobile robots are a typical autonomous intelligent system and a hot spot in the high-tech field. They are the intersection of multiple technical disciplines such as computer artificial intelligence, robotics, control theory and electronic technology. The product not only has potentially very attractive application value and commercial value, but the research on it is also a challenge to intelligent technology. The development of mobile robots provides excellent research for various intelligent technologies and solutions. This dissertation aims to study the research of multi-sensor information fusion and intelligent optimization methods and the methods of applying them to mobile robot related technologies, and in-depth study of the construction of mobile robot maps from the perspective of multi-sensor information fusion. And, in order to achieve this function, combined with autonomous exploration and other related theories and algorithms, combined with the Robot Operating System (ROS). This paper proposes the area equalization method, equalization method, fuzzy neural network and other methods to promote the realization of related technologies. At the same time, this paper conducts simulation research based on the SLAM comprehensive experiment of the JNPF-4WD square mobile robot. On this basis, the high precision and high reliability of robot positioning are further realized. The experimental results in this paper show that the maximum error of the X-axis and Y-axis, FastSLAM algorithm is smaller than EKF algorithm, and the improved FASTSALM algorithm error is further reduced compared with the original FastSLAM algorithm, the value is less than 0.1.
The genus Entomophthora: bringing the insect destroyers into the twenty-first century
Authors: Elya Carolyn , De Fine Licht Henrik H. 
Published: November 2021

AbstractThe fungal genus Entomophthora consists of highly host-specific pathogens that cause deadly epizootics in their various insect hosts. The most well-known among these is the “zombie fly” fungus E. muscae, which, like other Entomophthora species, elicits a series of dramatic behaviors in infected hosts to promote optimal spore dispersal. Despite having been first described more than 160 years ago, there are still many open questions about Entomophthora biology, including the molecular underpinnings of host behavior manipulation and host specificity. This review provides a comprehensive overview of our current understanding of the biology of Entomophthora fungi and enumerates the most pressing outstanding questions that should be addressed in the field. We briefly review the discovery of Entomophthora and provide a summary of the 21 recognized Entomophthora species, including their type hosts, methods of transmission (ejection of spores after or before host death), and for which molecular data are available. Further, we argue that this genus is globally distributed, based on a compilation of Entomophthora records in the literature and in online naturalist databases, and likely to contain additional species. Evidence for strain-level specificity of hosts is summarized and directly compared to phylogenies of Entomophthora and the class Insecta. A detailed description of Entomophthora’s life-cycle and observed manipulated behaviors is provided and used to summarize a consensus for ideal growth conditions. We discuss evidence for Entomophthora’s adaptation to growth exclusively inside insects, such as producing wall-less hyphal bodies and a unique set of subtilisin-like proteases to penetrate the insect cuticle. However, we are only starting to understand the functions of unusual molecular and genomic characteristics, such as having large > 1 Gb genomes full of repetitive elements and potential functional diploidy. We argue that the high host-specificity and obligate life-style of most Entomophthora species provides ample scope for having been shaped by close coevolution with insects despite the current general lack of such evidence. Finally, we propose six major directions for future Entomophthora research and in doing so hope to provide a foundation for future studies of these fungi and their interaction with insects.
Localizing microseismic events on field data using a U-Net-based convolutional neural network trained on synthetic data
Authors: Vinard N. A. , Drijkoningen G. G. , Verschuur D. J. 
Published: November 2021

Hydraulic fracturing (HF) plays an important role when it comes to the extraction of resources in unconventional reservoirs. The microseismic activity arising during HF operations needs to be monitored to improve productivity and to make decisions about mitigation measures. Recently, deep-learning methods have been investigated to localize earthquakes given field-data waveforms as input. For optimal results, these methods require large field data sets that cover the entire region of interest. In practice, such data sets often are scarce. To overcome this shortcoming, we have initially used a (large) synthetic data set with full waveforms to train a U-Net that reconstructs the source location as a 3D Gaussian distribution. As a field data set for our study, we use data recorded during HF operations in Texas. Synthetic waveforms are modeled using a velocity model from the site that is also used for a conventional diffraction-stacking (DS) approach. To increase the U-Nets’ ability to localize seismic events, we augment the synthetic data with different techniques, including the addition of field noise. We select the best performing U-Net using 22 events that have previously been identified to be confidently localized by DS and apply that U-Net to all 1245 events. We compare our predicted locations to DS and the DS locations refined by a relative location (DSRL) method. The U-Net-based locations are better constrained in depth compared to DS and the mean hypocenter difference with respect to DSRL locations is 163 m. This indicates potential for the use of synthetic data to complement or replace field data for training. Furthermore, after training, the method returns the source locations in near real time given the full waveforms, alleviating the need to pick arrival times.
Blinatumomab Nonresponse and High-Disease Burden Are Associated With Inferior Outcomes After CD19-CAR for B-ALL
Authors: Myers Regina M. , Taraseviciute Agne , Steinberg Seth M. , Lamble Adam J. , Sheppard Jennifer , Yates Bonnie , Kovach Alexandra E. , Wood Brent , Borowitz Michael J. , Stetler-Stevenson Maryalice , Yuan Constance M. , Pillai Vinodh , Foley Toni , Chung Perry , Chen Lee , Lee Daniel W. , Annesley Colleen , DiNofia Amanda , Grupp Stephan A. , John Samuel , Bhojwani Deepa , Brown Patrick A. , Laetsch Theodore W. , Gore Lia , Gardner Rebecca A. , Rheingold Susan R. , Pulsipher Michael A. , Shah Nirali N. 
Published: November 2021

PURPOSE CD19-targeted chimeric antigen receptor T cells (CD19-CAR) and blinatumomab effectively induce remission in relapsed or refractory B-cell acute lymphoblastic leukemia (ALL) but are also associated with CD19 antigen modulation. There are limited data regarding the impact of prior blinatumomab exposure on subsequent CD19-CAR outcomes. PATIENTS AND METHODS We conducted a multicenter, retrospective review of children and young adults with relapsed or refractory ALL who received CD19-CAR between 2012 and 2019. Primary objectives addressed 6-month relapse-free survival (RFS) and event-free survival (EFS), stratified by blinatumomab use. Secondary objectives included comparison of longer-term survival outcomes, complete remission rates, CD19 modulation, and identification of factors associated with EFS. RESULTS Of 420 patients (median age, 12.7 years; interquartile range, 7.1-17.5) treated with commercial tisagenlecleucel or one of three investigational CD19-CAR constructs, 77 (18.3%) received prior blinatumomab. Blinatumomab-exposed patients more frequently harbored KMT2A rearrangements and underwent a prior stem-cell transplant than blinatumomab-naïve patients. Among patients evaluable for CD19-CAR response (n = 412), blinatumomab nonresponders had lower complete remission rates to CD19-CAR (20 of 31, 64.5%) than blinatumomab responders (39 of 42, 92.9%) or blinatumomab-naive patients (317 of 339, 93.5%), P < .0001. Following CD19-CAR, blinatumomab nonresponders had worse 6-month EFS (27.3%; 95% CI, 13.6 to 43.0) compared with blinatumomab responders (66.9%; 95% CI, 50.6 to 78.9; P < .0001) or blinatumomab-naïve patients (72.6%; 95% CI, 67.5 to 77; P < .0001) and worse RFS. High-disease burden independently associated with inferior EFS. CD19-dim or partial expression (preinfusion) was more frequently seen in blinatumomab-exposed patients (13.3% v 6.5%; P = .06) and associated with lower EFS and RFS. CONCLUSION With the largest series to date in pediatric CD19-CAR, and, to our knowledge, the first to study the impact of sequential CD19 targeting, we demonstrate that blinatumomab nonresponse and high-disease burden were independently associated with worse RFS and EFS, identifying important indicators of long-term outcomes following CD19-CAR.
TPSL: A propagation source localization method based on limited observation nodes
Authors: Wang Chao , Man Ziqian , Yuan Shunjie , Zhang Gaoyu 
Published: November 2021

Abstract
The research on locating the sources that initiate a diffusion process on complex networks has far-reaching significance in various fields. In this paper, we propose the multi-source localization method TPSL based on limited observation nodes from the perspectives of infection time and infection probability. Simulations on both the synthetic and empirical networks demonstrate that TPSL has excellent performance. We also explore the influence of different strategies of selecting observation nodes on the performance of TPSL and find out that selecting the nodes with larger closeness centrality as observers performs best.
Distinct properties of vortex bound states driven by temperature
Authors: Fan Xinwei , Chen Xiaoyu , Yang Huan , Wen Hai-Hu 
Published: November 2021

Abstract
We investigate the behavior of vortex bound states in the quantum limit by self-consistently solving the Bogoliubov-de Gennes equation. We find that the energies of the vortex bound states deviates from the analytical result

with the half-integer angular momentum μ at very low temperature. Specifically, the energy ratio for the first three orders is closer to 1: 2: 3 than to 1: 3: 5 in the extreme quantum limit

. The local density of states reveals a Friedel-like behavior associated with that of the pair potential, which will be smoothed out by the thermal effect above the quantum limit. Our studies show that the vortex bound states can exhibit very distinct features in different temperature regimes, which provides a comprehensive understanding and should stimulate more experimental efforts for verification.
Exploring digital filters for internal root resorption: how can we improve the diagnosis of small lesions?
Authors: da Silveira Tiecher Priscila Fernanda , Assein Arús Nádia , Adams Hilgert Eduarda , Dias da Silveira Heloisa Emilia , Pante Fontana Mathias , Dias da Silveira Heraldo Luís , Vizzotto Mariana Boessio 
Published: November 2021

Objectives: This study aimed to evaluate the impact of enhancement filters in detecting small simulated internal root resorptions (IRR). Methods: : Forty-two extracted human teeth were sectioned, connected, and stored in a dry human jaw and X-rayed with photostimulable phosphor plates (PSPs), composing the control group (CG). In the middle-third of the root canals, IRR lesions were simulated using Da Silveira protocol. Later, the specimens were X-rayed to create the test group (TG). All images acquired were exported with seven enhancement filters plus the original image. Three examiners used a five-point Likert scale to evaluate the images regarding the presence/absence of IRR. Diagnostic efficacy was assessed from sensitivity and specificity results. Comparison among filters was performed by using receiver operating characteristic (ROC) curve analysis. Results: : Moderate values of Kappa interexaminer (0.403–0.620) and high values of Kappa intraexaminer (0.757–0.915) were observed. The best performance occurred in the CG (p < 0.05). Original images presented the greatest sensitivity and area under the ROC curve (0.595–0.750), while the Endo filter presented the greatest specificity (0.952). Inversion and Pseudo-3D images produced the greatest doubt in the diagnosis, significant for CG with the Pseudo-3D filter (p < 0.05). Conclusions: : The Original and ‘Endo’ filters should be chosen as it offers greater diagnostic ability and allows more confidence during the evaluation.
Comparison of cortisol levels in patients with vasovagal syncope and postural tachycardia syndrome
Authors: Fayyaz Humaira , Ambreen Shazadi , Raziq Hammad , Hayyat Azmat 
Published: November 2021

Objectives: To compare the levels of cortisol in patients of vasovagal syncope (VVS) and postural tachycardia syndrome (POTS).
Methods: A cross-sectional analytical study was conducted at Islamic International Medical College, Rawalpindi and Electrophysiology Department at (AFIC). This study included 80 subjects, comprising of 35 patients in each group of vasovagal syncope and postural tachycardia syndrome and 10 healthy subjects. Patients with complaint of syncope was evaluated for vasovagal syncope and postural tachycardia syndrome using Head Up Tilt Test (HUTT). Blood samples of all the participants were taken and serum cortisol was analyzed using ELISA method. Results were analyzed on SPSS Statistics 21 using ANOVA with a p-value of ≤0.05 regarded as significant.
Results: Hormonal analysis shows that cortisol levels in the vasovagal, postural tachycardia syndrome and in control group was 153±16.7pg/ml, 160.17±pg/ml, and 69.65±5.8pg/ml respectively. Cortisol levels were significantly higher in both vasovagal and POTS groups as compared to controls with a p-value of 0.04 and 0.023 respectively. However, there was no significant difference between vasovagal and POTS patients with p value 0.570.
Conclusion: It is concluded from the study that cortisol responses of VVS and POTS were positive.
doi: https://doi.org/10.12669/pjms.38.1.4122
How to cite this:Khan HF, Ambreen S, Raziq H, Hayat A. Comparison of cortisol levels in patients with vasovagal syncope and postural tachycardia syndrome. Pak J Med Sci. 2022;38(1):185-189. doi: https://doi.org/10.12669/pjms.38.1.4122
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Journal Club is a way forward to adopt Evidence Based Practice among dental House Officers
Authors: Bana Kiran Fatima Mehboob Ali 
Published: November 2021

Objectives: To identify the improvement in knowledge, presentation skills, critical skills and self-directed learning process during Journal Club platform amidst dental house officers of 2018, 2019 and 2020 after completing one year house job training at Bahria dental College Karachi.
Methods: This cross-sectional study was conducted from Dec- 2018 till Dec-2020. The six items were asked about perception of change for evidence-based process of (knowledge, cognitive, affective and participant domains) after completion of house job training by each cohort. The responses were noted on three point likert scale as agree, neutral and disagree. Total 150 questionnaires were distributed in three cohorts. The SPSS version 23 was used. P-value <0.05 was considered as statistically significant.
Results: Total n=145 house officers had completed the proforma with response rate of 96.65%. The mean age was 24.45 ± SD 0.63 among three groups. There were n=20(14%) males and n=125(86%) females. There was improvement found for knowledge acquisition about relevant literature search among all three groups. Regarding knowledge acquisition of bio-statistics; majority of subjects n=26 (52%) in 2020 group had reported no change and in 2019 cohort n=23(48%) were agreed. Majority n=21(44%) of house officers had reported no change when asked as JC helped in critical thinking in year 2019.
Conclusion: Knowledge acquisition about relevant literature search, presentation and confidence skills were improved but no significant changes were found in knowledge of biostatistics and critical thinking skills. JC is a convincing platform to learn evidence-based process amid dental house officers.
doi: https://doi.org/10.12669/pjms.38.1.4562
How to cite this:Bana KFMA. Journal Club is a way forward to adopt Evidence Based Practice among dental House Officers. Pak J Med Sci. 2022;38(1):195-200. doi: https://doi.org/10.12669/pjms.38.1.4562
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Clinical study on vacuum assisted closure combined with multiple flaps in the treatment of severe hand trauma
Authors: Wang Quan , Zhang Xu , Sun Wentao , Li Hua 
Published: November 2021

Objectives: To investigate the effect and clinical value of the application of vacuum assisted closure (VAC) combined with multiple flaps in the treatment of severe hand trauma.
Methods: A total of 100 patients with severe hand trauma admitted to Harrison International Peace Hospital from September 2015 to September 2020 were selected and randomly divided into two groups according to the randomized block method: the single flap repair group and the combined repair group, with 50 patients in each group. Patients in the single flap repair group underwent flap repair according to their condition, while those in the combined repair group were treated with VAC prior to flap repair. The range of motion and hand sensation scores were compared between the two groups, and their levels of interleukin-8 (IL-8), tumor necrosis factor (TNF) and lipopolysaccharide (LPS) were tested by enzyme-linked immunosorbent assay (ELIS). Moreover, the flap survival rate and the incidence of adverse events were recorded and compared between the two groups.
Results: Compared with the single flap repair group, the combined repair group had higher range of motion and hand sensation score (p<0.05), lower levels of IL-8, TNF and LPS (p<0.05), higher flap survival rate (p<0.05), and lower incidence of adverse events (p<0.05).
Conclusion: VAC combined with multiple flaps boasts significant trauma repair effect and preferable clinical application value in the treatment of patients with severe hand trauma, which is principally reflected in significantly improving the hand function of patients and remarkably alleviating the inflammatory response of patients.
doi: https://doi.org/10.12669/pjms.38.1.4631
How to cite this:Wang Q, Zhang X, Sun W, Li H. Clinical study on vacuum assisted closure combined with multiple flaps in the treatment of severe hand trauma. Pak J Med Sci. 2022;38(1):248-253. doi: https://doi.org/10.12669/pjms.38.1.4631
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Expressions of IGF-1R and Ki-67 in breast cancer patients with diabetes mellitus and an analysis of biological characteristics
Authors: Yan Xiaolu , Gao Zhe , Zhou Ye , Gao Fei , Li Qingxia 
Published: November 2021

Objectives: There is a cross-link of insulin and insulin-like growth factor-1 (IGF-1) with each other’s receptors. The present study was carried out to explore the relationship of Type-2 diabetes mellitus (T2DM) with the occurrence and development of breast cancer by analyzing the expression of IGF-1R and Ki-67, as well as the biological characteristics in breast cancer patients with and without diabetes mellitus.
Methods: A total of 102 cases of breast cancer patients with T2DM admitted in Hebei General Hospital from January 2019 to December 2020 were selected and grouped in T2DM group. While the control group included 106 cases of breast cancer patients without diabetes mellitus in the same period. Further comparison was conducted focusing on the general data, clinical stage, tumor histological grade, molecular classification and prognosis, and the expressions of IGF-1R and Ki-67 in breast cancer tissue between groups.
Results: Compared with control group, patients in T2DM group were elderly and accounted for a larger proportion of post-menopause (p<0.05), yet with no significant difference in body mass and family history (p>0.05). Compared with control group, T2DM group had advanced clinical stage, higher histological grade, and more common molecular type, with statistical differences between groups (p<0.05). Furthermore, there were higher proportions of local recurrence, lymph node metastasis and distant metastasis in T2DM group than those in control group, yet with no statistical significance (p>0.05). While statistical difference was found in the comparison of the 5-year survival rate, which was lower in T2DM group than that in control group (p<0.05). In addition, compared with control group, there were significant increase in both the expressions of IGF-1R and Ki-67 in T2DM group (p<0.05).
Conclusions: T2DM may be one of the risk factors affecting the occurrence, development and prognosis of breast cancer, which may decrease the 5-year survival of breast cancer patients. Besides, high expressions of IGF-1R and Ki-67 may be the key factors for poor prognosis of breast cancer patients with diabetes mellitus.
doi: https://doi.org/10.12669/pjms.38.1.4718
How to cite this:Yan X, Gao Z, Zhou Y, Gao F, Li Q. Expressions of IGF-1R and Ki-67 in breast cancer patients with diabetes mellitus and an analysis of biological characteristics. Pak J Med Sci. 2022;38(1):281-286. doi: https://doi.org/10.12669/pjms.38.1.4718
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.