bluuebunny/crossref_metadata_2025_split huggingface dataset:
The CARMENES search for exoplanets around M dwarfs
Authors: Lafarga M. , Ribas I. , Reiners A. , Quirrenbach A. , Amado P. J. , Caballero J. A. , Azzaro M. , Béjar V. J. S. , Cortés-Contreras M. , Dreizler S. , Hatzes A. P. , Henning Th. , Jeffers S. V. , Kaminski A. , Kürster M. , Montes D. , Morales J. C. , Oshagh M. , Rodríguez-López C. , Schöfer P. , Schweitzer A. , Zechmeister M. 
Published: May 2021

Context. Stellar activity poses one of the main obstacles for the detection and characterisation of small exoplanets around cool stars, as it can induce radial velocity (RV) signals that can hide or mimic the presence of planetary companions. Several indicators of stellar activity are routinely used to identify activity-related signals in RVs, but not all indicators trace exactly the same activity effects, nor are any of them always effective in all stars.
Aims. We evaluate the performance of a set of spectroscopic activity indicators for M dwarf stars with different masses and activity levels with the aim of finding a relation between the indicators and stellar properties.
Methods. In a sample of 98 M dwarfs observed with CARMENES, we analyse the temporal behaviour of RVs and nine spectroscopic activity indicators: cross-correlation function (CCF) full-width-at-half-maximum (FWHM), CCF contrast, CCF bisector inverse slope (BIS), RV chromatic index (CRX), differential line width (dLW), and indices of the chromospheric lines Hα and calcium infrared triplet.
Results. A total of 56 stars of the initial sample show periodic signals related to activity in at least one of these ten parameters. RV is the parameter for which most of the targets show an activity-related signal. CRX and BIS are effective activity tracers for the most active stars in the sample, especially stars with a relatively high mass, while for less active stars, chromospheric lines perform best. FWHM and dLW show a similar behaviour in all mass and activity regimes, with the highest number of activity detections in the low-mass, high-activity regime. Most of the targets for which we cannot identify any activity-related signals are stars at the low-mass end of the sample (i.e. with the latest spectral types). These low-mass stars also show the lowest RV scatter, which indicates that ultracool M dwarfs could be better candidates for planet searches than earlier types, which show larger RV jitter.
Conclusions. Our results show that the spectroscopic activity indicators analysed behave differently, depending on the mass and activity level of the target star. This underlines the importance of considering different indicators of stellar activity when studying the variability of RV measurements. Therefore, when assessing the origin of an RV signal, it is critical to take into account a large set of indicators, or at least the most effective ones considering the characteristics of the star, as failing to do so may lead to false planet claims.
Comparing Eyesi Virtual Reality Simulator and Traditional Teaching Methods for Direct Ophthalmoscopy: Students' Perspectives at Indiana University School of Medicine
Authors: Tso Hanna L. , Young Jason , Yung C. W. 
Published: May 2021

Abstract
Background The fundus examination is an essential part of any ophthalmologic evaluation. However, medical students and primary care physicians often lack confidence with direct ophthalmoscopy. Virtual reality simulators are being employed in medical education to teach this technically challenging examination.
Objective To compare medical student ratings of the Eyesi Direct Ophthalmoscope Simulator and traditional small group teaching methods for learning direct ophthalmoscopy skills.
Methods All medical students at Indiana University School of Medicine traditionally learn direct ophthalmoscopy in their first 2 years during a small group session led by a physician instructor. Students who later enrolled in ophthalmology clinical electives during 2019 and 2020 were invited to additionally complete the Eyesi Direct Ophthalmoscope Simulator virtual reality curriculum. A voluntary, anonymous survey was sent between June and August 2020 to students who had completed both the traditional and Eyesi simulator sessions. Students were asked to rate their confidence in performing direct ophthalmoscopy following each session, and to indicate which teaching method was superior and why. Chi-square analysis was used to compare categorical variables.
Results Students' confidence ratings for performing direct ophthalmoscopy were significantly higher following completion of the Eyesi simulator session compared with the traditional small group session (p < 0.001). Four-fifths of respondents felt that the Eyesi simulator was superior to the traditional small group for learning the skills of direct ophthalmoscopy, while one-fifth felt that the two sessions were equally effective (p < 0.001). None of the students responded that the small group session was the superior teaching method.
Conclusion The Eyesi Direct Ophthalmoscope Simulator was rated highly among medical students and offers distinct learning advantages that could not be replicated in a traditional small group environment, such as providing numerous examples of pathological findings and allowing unlimited examination time without concern for patient's inconvenience or light exposure. The Eyesi simulator is a promising tool for teaching direct ophthalmoscopy to medical students. Ultimately, familiarity with the fundus examination will enable future physicians across specialties to better evaluate and appropriately refer patients with ocular fundus pathology.
An Artificial Intelligence Tool for Image Simulation in Rhinoplasty
Authors: Chinski Hernan , Lerch Ricardo , Tournour Damián , Chinski Luis , Caruso Diego 
Published: May 2021

AbstractDuring rhinoplasty consultations, surgeons typically create a computer simulation of the expected result. An artificial intelligence model (AIM) can learn a surgeon's style and criteria and generate the simulation automatically. The objective of this study is to determine if an AIM is capable of imitating a surgeon's criteria to generate simulated images of an aesthetic rhinoplasty surgery. This is a cross-sectional survey study of resident and specialist doctors in otolaryngology conducted in the month of November 2019 during a rhinoplasty conference. Sequential images of rhinoplasty simulations created by a surgeon and by an AIM were shown at random. Participants used a seven-point Likert scale to evaluate their level of agreement with the simulation images they were shown, with 1 indicating total disagreement and 7 total agreement. Ninety-seven of 122 doctors agreed to participate in the survey. The median level of agreement between the participant and the surgeon was 6 (interquartile range or IQR 5–7); between the participant and the AIM it was 5 (IQR 4–6), p-value < 0.0001. The evaluators were in total or partial agreement with the results of the AIM's simulation 68.4% of the time (95% confidence interval or CI 64.9–71.7). They were in total or partial agreement with the surgeon's simulation 77.3% of the time (95% CI 74.2–80.3). An AIM can emulate a surgeon's aesthetic criteria to generate a computer-simulated image of rhinoplasty. This can allow patients to have a realistic approximation of the possible results of a rhinoplasty ahead of an in-person consultation. The level of evidence of the study is 4.
Comparative Outcomes by Surgical Approach in Patients with Malignant Sinonasal Disease
Authors: Lenze Nicholas R. , Quinsey Carolyn , Sasaki-Adams Deanna , Ewend Matthew G. , Thorp Brian D. , Ebert Charles S. , Zanation Adam M. 
Published: May 2021

Abstract
Objective There is a paucity of data on comparative outcomes for open versus endoscopic surgery for patients with malignant sinonasal pathology. Most of the available studies are limited by a sample size <100 patients.
Design This is a retrospective cohort study.
Setting The findings of this study come from a single-institution tertiary care center from 2008 to 2019.
Participants In total, 199 patients who underwent surgery for malignant sinonasal disease participated in this study.
Main Outcome Measures The main outcome measures were perioperative complications and reoperation.
Results Patients in our sample had a mean age of 59.7 years (SD, 20.4). In total, 62% were male and 72% were white. An endoscopic-only approach was used in 41% of patients and an open or combined approach in 59% of patients. Squamous cell carcinoma was the most common pathology (43.0%), followed by sarcoma (9.5%), skin cancer (6.5%), sinonasal undifferentiated carcinoma (6.5%), and adenocarcinoma (5.5%). The all-cause complication rate was 14.6%. Patients with an open resection had a higher rate of intraoperative complications (5.9 vs. 0%; p = 0.043), postoperative complications (19.5 vs. 3.7%; p = 0.001), and all-cause complications (21.0 vs. 3.7%; p < 0.001). The likelihood of early reoperation (<6 months) or late reoperation (>6 months) did not significantly differ by surgical approach (p = 1.000 and 0.741, respectively).
Conclusion The endoscopic approach for resection of malignant sinonasal disease is viable for select patients and may be associated with a favorable complication rate compared with the open approach.
Two Rare Syndromic Syndactyly Cases in Neonates
Authors: Kamath Pooja Prabhakar 
Published: May 2021

Abstract
Introduction Isolated findings of syndactyly are benign. However, syndactyly can be associated with rare syndromes that need to be diagnosed for further management and for genetic counseling.
Methods We present two cases of syndromic syndactyly in neonates. The first case is a 13-day-old female neonate with dysmorphic features. The neonate had clinical features of prominent forehead, hypertelorism, widely separated sagittal and metopic sutures, down-slanting eyes, low set ears, depressed nasal bridge, micrognathia, cleft palate, pectus excavatum, brachydactyly, and syndactyly of the second to fourth fingers bilaterally in upper limbs and in lower limbs.The second case is a 10-day-old male neonate with dysmorphism in the form of cleft alveolar ridge and palate, hyperplastic frenula, hypoplastic alar cartilage, syndactyly of the left hand, clinodactyly of the left lower limb toes, and amniotic bands.
Discussion Case 1 was diagnosed as otopalatodigital syndrome because of the characteristic clinical features. This is a rare syndrome associated with syndactyly that often goes undiagnosed. Otopalatodigital syndrome spectrum disorders comprise of four phenotypically related conditions: otopalatodigital syndrome types 1 and 2, frontometaphyseal dysplasia, and Melnick–Needles syndrome. As it is associated with x-linked inheritance, its severity is more in males.Case 2 was diagnosed to have orofaciodigital syndrome because of the characteristic clinical features. It is another rare syndrome associated with syndactyly having abnormalities in the development of the oral cavity, face, and digits along with intellectual disability and renal system impairment.
Conclusion There are fewer publications on these syndromes as they are rare and diagnosis is difficult. Recognizing these syndromes is key to further management and for genetic counseling.
A Prospective Evaluation of Quality of Life in Patients Undergoing Extended Endoscopic Endonasal Surgery for Benign Pituitary Gland Lesion
Authors: Carmel Neiderman Narin Nard , Wengier Anat , Dominsky Omri , Ringel Barak , Warshavsky Anton , Horowitz Gilad , Baran Tomer Ziv , Ram Zvi , Grossman Rachel , Fliss Dan Marian , Avraham Abergel 
Published: May 2021

Abstract
Introduction Endoscopic endonasal surgery (EES) has become the preferred approach for pituitary tumor resection. Nevertheless, research on quality of life related to pituitary adenoma surgery is scarce.
Objective The aim of the study is to evaluate short-term quality of life in patients after endoscopic endonasal resection of pituitary tumors and to find predictors for poor quality of life (QOL) outcome.
Materials and Methods A prospective cohort study was conducted, including all patients who underwent EES for pituitary tumors in a tertiary medical referral center. Recruited patients completed the Anterior Skull Base Disease-Specific QOL (ASBS-Q) questionnaire and the Sinonasal Outcome Test 22 (SNOT-22) questionnaire before surgery, 2 and 4 to 6 months after surgery. Demographic and clinical data was collected.
Results Our study included 49 patients. The overall ASBS-Q scores significantly improved 4 to 6 months after surgery (4.46 vs. 4.2, p < 0.05). We found a significant improvement in QOL related to emotional state 2 months post surgery (4.41 vs. 3.87, p < 0.05), which became borderline significant 4 to 6 months post surgery. There was a significant improvement in pain (4.5 vs. 4.08, p < 0.05) and vitality (4.43 vs. 4.16, p < 0.05) domains 4 to 6 months post surgery. SNOT-22 scores did not change significantly postoperatively. Factors such as secreting and non-secreting tumors, tumor size, intraoperative cerebrospinal fluid leak, gross tumor resection, endocrine remission, and the use of nasoseptal flap reconstruction did not have a significant effect on QOL.
Conclusion We found that patients after EES reported improved QOL 4 to 6 months post surgery. Specific improvement was noted in the QOL related to pain and vitality.
Factor investing and asset allocation strategies: a comparison of factor versus sector optimization
Authors: Bessler Wolfgang , Taushanov Georgi , Wolff Dominik 
Published: May 2021

AbstractGiven the tremendous growth of factor allocation strategies in active and passive fund management, we investigate whether factor or sector asset allocation strategies provide investors with a superior performance. Our focus is on comparing factor versus sector allocations as some recent empirical evidence indicates the dominance of sector over country portfolios. We analyze the performance and performance differences of sector and factor portfolios for various weighting and portfolio optimization approaches, including “equal-weighting” (1/N), “risk parity,” minimum-variance, mean-variance, Bayes–Stein and Black–Litterman. We employ a sample-based approach in which the sample moments are the input parameters for the allocation model. For the period from May 2007 to November 2020, our results clearly reveal that, over longer investment horizons, factor portfolios provide relative superior performances. For shorter periods, however, we observe time-varying and alternating performance dominances as the relative advantage of one over the other strategy depends on the economic cycle. One important insight is that during “normal” times factor portfolios clearly dominate sector portfolios, whereas during crisis periods sector portfolios are superior offering better diversification opportunities.
Sporisorium sacchari (Asian sugarcane smut).
Authors:   USA, USDA-ARS
Published: May 2021

Abstract

Little published information exists on this plant pathogenic fungus of limited geographic distribution. S. sacchari is one of several Asian species only parasitizing the flowers of Saccharum species, thus causing much less damage to the plants than does the more widespread sugarcane smut that infects buds and reduces the growth of shoots. Although windborne, and probably contaminating seeds, S. sacchari spreads less well with the vegetatively propagated cane plants. Nevertheless, its effects on other possible hosts could pose a threat to native or agricultural plants if it were introduced.
Conotrachelus nenuphar (plum curculio).
Authors: Vincent Charles 
Published: May 2021

Abstract

The plum curculio, C. nenuphar, is native to North America and restricted to east of the Rocky Mountains. Although it feeds on several wild host plants and several species of cultivated pome and stone fruit, C. nenuphar has not extended its geographical range over the years. Given its life-cycle (larvae complete their development and diapause in the soil), it is not likely to be a global invasive species. It can be considered as a local invader, as it will invade any new orchard plant (apple: Malus; plum: Prunus; peach: Prunus) and thereby become a serious pest of these agricultural habitats.
Globodera pallida (white potato cyst nematode).
Authors: Rowe Janet 
Published: May 2021

Abstract

G. pallida originates from the Andes and is known to be present in 55 countries. It is found predominantly in temperate regions as is the related species, Globodera rostochiensis. It is possibly more difficult to manage than G. rostochiensis because there is currently less resistance available in commercially-grown potato cultivars. Egg-laden cysts are the most environmentally resistant and easily transportable stage in the parasites life cycle, and are found in soil particles, on host roots, stolons or tubers. The microscopic size of the cyst makes it difficult to detect, and it can successfully establish new infestations when an appropriate climate and host plant are available. Machinery used on infested land followed by use in otherwise uninfested areas is a common method of spread, for example, fumigation equipment that has not been cleaned before use in another area. Disinfection of farming tools, transport and clothing helps to keep uninfested land free from G. pallida. Wind, rain and flood water are also capable of redistributing viable cysts to create new infestations.
Comparative genome analysis using sample-specific string detection in accurate long reads
Authors: Khorsand Parsoa , Denti Luca ,   Human Genome Structural Variant Consortium, Bonizzoni Paola , Chikhi Rayan , Hormozdiari Fereydoun 
Published: May 2021

Abstract

Motivation
Comparative genome analysis of two or more whole-genome sequenced (WGS) samples is at the core of most applications in genomics. These include the discovery of genomic differences segregating in populations, case-control analysis in common diseases and diagnosing rare disorders. With the current progress of accurate long-read sequencing technologies (e.g. circular consensus sequencing from PacBio sequencers), we can dive into studying repeat regions of the genome (e.g. segmental duplications) and hard-to-detect variants (e.g. complex structural variants).

Results
We propose a novel framework for comparative genome analysis through the discovery of strings that are specific to one genome (‘samples-specific’ strings). We have developed a novel, accurate and efficient computational method for the discovery of sample-specific strings between two groups of WGS samples. The proposed approach will give us the ability to perform comparative genome analysis without the need to map the reads and is not hindered by shortcomings of the reference genome and mapping algorithms. We show that the proposed approach is capable of accurately finding sample-specific strings representing nearly all variation (&gt;98%) reported across pairs or trios of WGS samples using accurate long reads (e.g. PacBio HiFi data).

Availability and implementation
Data, code and instructions for reproducing the results presented in this manuscript are publicly available at https://github.com/Parsoa/PingPong.

Supplementary information
Supplementary data are available at Bioinformatics Advances online.
Multi-omics reveals a relationship between endometrial amino acid metabolism and autophagy in women with recurrent miscarriage
Authors: Hong Ling , Zhu Yuan Chang , Liu Su , Wu Tonghua , Li Yuye , Ye Lijun , Diao Lianghui , Zeng Yong 
Published: May 2021

Abstract
Deterioration of the endometrial environment is an essential cause of recurrent miscarriage (RM). However, current studies in terms of endometrial amino acid metabolic characterization and autophagy are still inadequate. We tried to (1) identify the alternation in metabolite profiles in the RM endometrium; (2) investigate the expression of autophagy-related proteins in RM; and (3) elucidate the association between amino acid metabolism and autophagy in RM. Our results showed that glutamine metabolites were up-regulated in the endometrium of RM women. The levels of autophagy-associated proteins, LC3B, ATG12, and Beclin-1, were significantly higher in RM. Hemostasis, autophagy and IFNα signaling were the top three differentially activated signaling pathways between women with RM and normal pregnancy. Interestingly the expression of AMPK and GCN2 was significantly up-regulated in the endometrium of women with RM, and the same expression trend was also observed in the human endometrial stromal cells cultured in glutamine deprivation medium. Furthermore, inhibition of AMPK decreased the level of GCN2, indicating a positive correlation between GCN2 and AMPK. The expression of GCN2 was consistent with the expression of ATG12 and beclin-1; however, it was opposite to that of p62. Exposure to glutamine deprivation increased the level of LC3B, GCN2, ATG12, and beclin-1. Altogether, these findings suggested significant crosstalk between amino acid metabolism and autophagy. In summary, our data suggested that aberrant crosstalk between amino acid metabolism and autophagy may contribute to the impaired endometrial microenvironment of RM. Our study may provide new insight into the diagnosis of RM due to endometrial factors.
Liver resection and ablation for squamous cell carcinoma liver metastases
Authors: Engstrand J , Abreu de Carvalho L F , Aghayan D , Balakrishnan A , Belli A , Björnsson B , Dasari B V M , Detry O , Di Martino M , Edwin B , Erdmann J , Fristedt R , Fusai G , Gimenez-Maurel T , Hemmingsson O , Hidalgo Salinas C , Isaksson B , Ivanecz A , Izzo F , Knoefel W T , Kron P , Lehwald-Tywuschik N , Lesurtel M , Lodge J P A , Machairas N , Marino M V , Martin V , Paterson A , Rystedt J , Sandström P , Serrablo A , Siriwardena A K , Taflin H , van Gulik T M , Yaqub S , Özden İ , Ramia J M , Sturesson C ,   on behalf of the E-AHPBA Scientific and Research Committee
Published: May 2021

Abstract

Background
Limited evidence exists to guide the management of patients with liver metastases from squamous cell carcinoma (SCC). The aim of this retrospective multicentre cohort study was to describe patterns of disease recurrence after liver resection/ablation for SCC liver metastases and factors associated with recurrence-free survival (RFS) and overall survival (OS).

Method
Members of the European–African Hepato-Pancreato-Biliary Association were invited to include all consecutive patients undergoing liver resection/ablation for SCC liver metastases between 2002 and 2019. Patient, tumour and perioperative characteristics were analysed with regard to RFS and OS.

Results
Among the 102 patients included from 24 European centres, 56 patients had anal cancer, and 46 patients had SCC from other origin. RFS in patients with anal cancer and non-anal cancer was 16 and 9 months, respectively (P = 0.134). A positive resection margin significantly influenced RFS for both anal cancer and non-anal cancer liver metastases (hazard ratio 6.82, 95 per cent c.i. 2.40 to 19.35, for the entire cohort). Median survival duration and 5-year OS rate among patients with anal cancer and non-anal cancer were 50 months and 45 per cent and 21 months and 25 per cent, respectively. For the entire cohort, only non-radical resection was associated with worse overall survival (hazard ratio 3.21, 95 per cent c.i. 1.24 to 8.30).

Conclusion
Liver resection/ablation of liver metastases from SCC can result in long-term survival. Survival was superior in treated patients with liver metastases from anal versus non-anal cancer. A negative resection margin is paramount for acceptable outcome.