bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling the Growth of Four Commercial Broiler Genotypes Reared in the Tropics
Authors: Hagan Bernard Ato , Asumah Christian , Yeboah Ernest Darkwah , Lamptey Vida Korkor 
Published: October 2021

Abstract
Genetic improvement in commercial broilers worldwide is heavily focused on selection for higher final body weight at a given age. Although commercial broilers are mostly sold by their final body weight, it is important to pay attention to how this weight is attained and at what cost. The cost of feeding broilers, which constitutes about 70% of the total cost of broiler production, varies considerably at different stages of the bird. It is, therefore, important to pay attention to the growth curve of broilers and the parameters of the growth curve to maximise profitability of commercial broiler production. The objective of this study was to model the variations of the growth curves of 4 commercial broiler genotypes reared in Ghana using the Gompertz and polynomial growth functions. Data on body weights at 1, 7, 14, 21, 28, 35 and 42 days for 4 unsexed commercial broiler genotypes were used to model both the Gompertz and polynomial growth functions. The 4 genotypes ranked differently for Gompertz predicted early (1 - 28 days), late growth (28 – 42 days) and body weight at 42 days. Gompertz function predicted growth better for broiler chicken than the polynomial as the parameters of the Gompertz function are biologically meaningful and heritable. Selection of broiler genotypes for production based on their growth curve (slower early growth and faster late growth) could minimize cost of production and thereby increase the profitability of commercial broiler production in the tropics.
FADD Deficiency Mimicking ALPS-FAS: An Expanding Phenotype.
Authors: Setia Priyanka , Bargir Umair Ahmed , Shanmukhaiah Chandrakala , Jodhawat Neha , Kambli Priyanka , Gupta Maya , Dalvi Aparna , Shinde Shweta , Nambiar Nayana , Sawant Sneha , Shelar Shraddha , Gaikwad Pallavi , Dhawale Amruta , Mohanty Madhu , Agarwal Mukesh , Yadav Reetika Malik , Madkaikar Manisha 
Published: October 2021

Abstract
Autoimmune lymphoproliferative syndrome (ALPS) is caused due to defects in the Fas-mediated apoptotic pathway. This disease is characterised by chronic non -malignant lymphoproliferation, autoimmune cytopenias and accumulation of double-negative T cells. FAS is the most commonly affected gene observed in patients with ALPS. There is a paucity of data in other ALPS associated genes. Mutations in the FADD gene is extremely rare, and to date, only five patients with a homozygous mutation in exon 2 and one patient with a compound heterozygous mutation are reported. The clinical spectrum of FADD includes neurological dysfunction, recurrent bacterial and viral infections and liver dysfunction. Here we report two patients with novel FADD mutation with clinical phenotype like ALPS-FAS. This article provides an expanding phenotype of FADD deficiency where patients can solely present with lymphoproliferation and autoimmunity without any features of febrile episodes or neurodevelopmental delay. We identified a novel homozygous FADD mutation by targeted Next-generation sequencing (NGS). We performed a comprehensive immune evaluation along with biomarker estimation, mTOR activity on DNTs and apoptosis assay. We describe two siblings born to third-degree consanguineous marriage with homozygous FADD mutation. The index patient P1 presented with lymphoproliferation, autoimmune manifestations in the form of Evans phenotype, lymphocytosis and elevated DNTs, whereas P2 only had mild lymphoproliferation with no autoimmune manifestations. The mutation in our patients lies in exon 2 of the FADD gene, encoding the death domain. The death domain (DD) of FADD protein interacts directly with the death domains of Fas, and mutation at this site disrupts binding to Fas and abolishes apoptosis. FADD deficiency should also be considered in patients presenting with lymphoproliferation and autoimmunity since they can mimic clinical features of ALPS-FAS.
Comparison of different statistical downscaling models and future projection of areal mean precipitation of a river basin under climate change effect
Authors: Guven Aytac , Pala Abdulhadi 
Published: October 2021

Abstract
Investigation of the hydrological impacts of climate change at the local scale requires the use of a statistical downscaling technique. In order to use the output of a Global Circulation Model (GCM), a downscaling technique is used. In this study, statistical downscaling of monthly areal mean precipitation in the Göksun River basin in Turkey was carried out using the Group Method of Data Handling (GMDH), Support Vector Machine (SVM) and Gene Expression Programming (GEP) techniques. Large-scale weather factors were used for the basin with a monthly areal mean precipitation (PM) record from 1971 to 2000 used for training and testing periods. The R2-value for precipitation in the SVM, GEP and GMDH models are 0.62, 0.59, and 0.6 respectively, for the testing periods. The results show that SVM has the best model performance of the three proposed downscaling models, however, the GEP model has the lowest AIC value. The simulated results for the Canadian GCM3 (CGCM3) A1B and A2 scenarios show a similarity in their average precipitation prediction. Generally, both these scenarios anticipate a decrease in the average monthly precipitation during the simulated periods. Therefore, the results of the future projections show that mean precipitation might decrease during the period of 2021–2100.
The Role of Endothelial Related Circulating Biomarkers in
COVID-19. A Systematic Review and Meta-analysis
Authors: Lampsas Stamatios , Tsaplaris Paraskevas , Pantelidis Panteleimon , Oikonomou Evangelos , Marinos Georgios , Charalambous Georgios , Souvaliotis Nektarios , Mystakidi Vasiliki-Chara , Goliopoulou Athina , Katsianos Efstratios , Siasos Gerasimos , Vavuranakis Michael-Andrew , Tsioufis Costas , Vavuranakis Manolis , Tousoulis Dimitrios 
Published: October 2021

Background:
Several studies have revealed the link between Coronavirus Disease 2019 (COVID-19) and endothelial dysfunction. To better understand the global pattern of this relationship, we conducted a meta-analysis on endothelial biomarkers related to COVID-19 severity.

Methods:
We systematically searched the literature up to March 10, 2021, for studies investigating the association between COVID-19 severity and the following endothelial biomarkers: Intercellular Adhesion Molecule 1 (ICAM-1), Vascular Cell Adhesion Molecule 1 (VCAM-1), E-selectin, P-selectin, Von Willebrand Factor Antigen (VWF-Ag), soluble Thrombomodulin (sTM), Mid-regional pro-adrenomedullin (MR-proADM), and Angiopoietin-2 (Ang-2). Pooled estimates and mean differences (PMD) for each biomarker were reported.

Results:
A total of 27 studies (n=2213 patients) were included. Critically ill patients presented with higher levels of MR-proADM (PMD: 0.71 nmol/L, 95% CI: 0.22 to 1.20 nmol/L, p=0.02), E-selectin (PMD: 13,32 pg/ml, 95% CI: 4,89 to 21,75 pg/ml, p=0.008), VCAM-1 (PMD: 479 ng/ml, 95% CI: 64 to 896 ng/ml, p=0.03), VWF-Ag (PMD: 110.5 IU/dl, 95% CI: 44.8 to 176.1 IU/dl, p=0.04) and Ang-2 (PMD: 2388 pg/ml, 95% CI: 1121 to 3655 pg/ml, p=0.003), as compared to non-critically ill ones. ICAM-1, P-selectin and thrombomodulin did not differ between the two groups (p>0.05).

Conclusion:
Endothelial biomarkers display significant heterogeneity in COVID-19 patients, with higher MR-proADM, E-selectin, VCAM-1, VWF-Ag, and Ang-2 levels being associated with increased severity. These findings strengthen the evidence on the key role of endothelial dysfunction in disease progress.
Student Responses to Online Learning of Indonesian Language Subjects Based on LMS Moodle
Authors: Setyaningsih Vitria Indriyani , Rahmawati Laili Etika 
Published: October 2021

This study aims to describe students' responses to online learning of Indonesian language subjects based on Moodle LMS at SMP Negeri 17 Surakarta. The research approach used is descriptive qualitative research. The subject and object of the study focused on seventh grade students of SMP Negeri 17 Surakarta and Indonesian language teachers. The data collection technique in this study was through interview techniques by distributing questionnaires through Google Forms and literature studies. Data analysis techniques used interactive analysis techniques consisting of data reduction, data presentation, and drawing conclusions. The validity of the data was tested using data triangulation techniques and data sources. The results of this study indicate that the students' responses to online learning in Indonesian subjects showed a positive response. The questionnaire shows that students feel happy in online learning using the LMS Moodle for Indonesian subjects. The delivery of the subject matter is very easy to understand because the teacher uses animated videos and video teaching materials. The obstacles experienced during the learning process were handled well by the school's IT team and subject teachers who were very responsive. Respon Siswa terhadap Pembelajaran Daring Mata Pelajaran Bahasa Indonesia Berbasis LMS MoodlePenelitian ini bertujuan untuk mendeskripsikan respons siswa terhadap pembelajaran daring mata pelajaran Bahasa Indonesia berbasis LMS Moodle di SMP Negeri 17 Surakarta. Metode penelitian dilakukan melalui survey pendapat dari siswa menggunakan google form. subjek dan objek penelitian berfokus terhadap siswa kelas VII SMP Negeri 17 Surakarta dan guru Bahasa Indonesia. Teknik pengumpulan data dalam penelitian ini melalui teknik wawancara dengan menyebarkan kuesioner melalui Google Form dan studi pustaka. Teknik analisis data menggunakan teknik analisis interaktif yang terdiri dari reduksi data, penyajian data, dan penarikan kesimpulan. Uji keabsahan data dilakukan dengan teknik triangulasi data dan sumber data. Hasil penelitian ini yaitu respons siswa terhadap pembelajaran daring mata pelajaran Bahasa Indonesia menunjukkan respons yang positif. Kuesioner menunjukkan, siswa merasa senang dalam pembelajaran daring menggunakan LMS Moodle untuk mata pelajaran Bahasa Indonesia penyampaian materi pelajaran sangat mudah untuk dipahami karena guru menggunakan video animasi dan video bahan ajar. Kendala yang dialami ketika proses pembelajaran pun ditangani dengan baik oleh tim IT sekolah serta guru mata pelajaran yang sangat responsive.
Impulsivity, Self-control, Interpersonal Influences, and Maladaptive Cognitions as Factors of Internet Gaming Disorder Among Adolescents in China: Cross-sectional Mediation Study
Authors: Yu Yanqiu , Mo Phoenix Kit-Han , Zhang Jianxin , Li Jibin , Lau Joseph Tak-Fai 
Published: October 2021

BackgroundGaming disorder, including internet gaming disorder (IGD), was recently defined by the World Health Organization as a mental disease in the 11th Revision of the International Classification of Diseases (ICD-11). Thus, reducing IGD is warranted. Maladaptive cognitions related to internet gaming (MCIG) have been associated with IGD, while impulsivity, self-control, parental influences, and peer influences are key risk factors of IGD. Previous literature suggests that MCIG is associated with the aforementioned 4 risk factors and IGD, and may thus mediate between these risk factors and IGD. These potential mediations, if significant, imply that modification of MCIG may possibly alleviate these risk factors’ harmful impacts on increasing IGD. These mediation hypotheses were tested in this study for the first time.ObjectiveThis study tested the mediation effects of MCIG between intrapersonal factors (impulsivity and self-control) and IGD, and between interpersonal factors (parental influences and peer influences) and IGD among adolescents in China.MethodsAn anonymous, cross-sectional, and self-administered survey was conducted among secondary school students in classroom settings in Guangzhou and Chengdu, China. All grade 7 to 9 students (7 to 9 years of formal education) of 7 secondary schools were invited to join the study, and 3087 completed the survey. The Diagnostic and Statistical Manual of Mental Disorders (DSM-5) checklist was used to assess IGD. MCIG was assessed by using the Chinese version of the Revised Internet Gaming Cognition Scale. Impulsivity, self-control, and parental or peer influences were measured by using the motor subscale of the Barratt Impulsiveness Scale, the Brief Self-Control Scale, and the modified interpersonal influence scale, respectively. Structural equation modeling was conducted to examine the mediation effects of MCIG between these risk factors and IGD.ResultsThe prevalence of IGD was 13.57% (418/3081) and 17.67% (366/2071) among all participants and adolescent internet gamers, respectively. The 3 types of MCIG (perceived rewards of internet gaming, perceived urges for playing internet games, and perceived unwillingness to stop playing without completion of gaming tasks) were positively associated with IGD. Impulsivity, self-control, parental influences, and peer influences were all significantly associated with the 3 types of MCIG and IGD. The 3 types of MCIG partially mediated the associations between the studied factors and IGD (effect size of 30.0% to 37.8%).ConclusionsImpulsivity, self-control, and interpersonal influences had both direct and indirect effects via MCIG on IGD. Modifications of the 3 types of MCIG can potentially reduce the harmful impacts of impulsivity and interpersonal influences on IGD and enhance the protective effect of self-control against IGD. Future longitudinal studies are warranted.
Assessing Elderly User Preference for Telehealth Solutions in China: Exploratory Quantitative Study
Authors: Chen Nuoya , Liu Pengqi 
Published: October 2021

Background
In the next 15 to 20 years, the Chinese population will reach a plateau and start to decline. With the changing family structure and rushed urbanization policies, there will be greater demand for high-quality medical resources at urban centers and home-based elderly care driven by telehealth solutions. This paper describes an exploratory study regarding elderly users’ preference for telehealth solutions in the next 5 to 10 years in 4 cities, Shenzhen, Hangzhou, Wuhan, and Yichang.

Objective
The goal is to analyze why users choose telehealth solutions over traditional health solutions based on a questionnaire study involving 4 age groups (50-60, 61-70, 71-80, and 80+) in 4 cities (Shenzhen, Hangzhou, Wuhan, and Yichang) in the next 10 to 20 years. The legal retirement age for female workers in China is 50 to 55 years and 60 years for male workers. To simulate reality in terms of elderly care in China, the authors use the Chinese definition of elderly for employees, defined as being 50 to 60 years old rather than 65 years, as defined by the World Health Organization.

Methods
The questionnaires were collected from Shenzhen, Hangzhou, Wuhan, and Yichang randomly with 390 valid data samples. The questionnaire consists of 31 questions distributed offline on tablet devices by local investigators. Subsequently, Stata 16.0 and SPSS 24.0 were used to analyze the data. O-logit ordered regression and principal component analysis (PCA) were the main theoretical models used. The study is currently in the exploratory stage and therefore does not seek generalization of the results.

Results
Approximately 71.09% (280/390) of the respondents reported having at least 1 type of chronic disease. We started with PCA and categorized all Likert scale variables into 3 factors. The influence of demographic variables on Factors 1, 2, and 3 was verified using analysis of variance (ANOVA) and t tests. The ordered logit regression results suggest that health-related motivations are positively related to the willingness to use telehealth solutions, and trust on data collected from telehealth solutions is negatively correlated with the willingness to use telehealth solutions.

Conclusions
The findings suggest that there is a need to address the gap in community health care and ensure health care continuity between different levels of health care institutions in China by providing telehealth solutions. Meanwhile, telehealth solution providers must focus on improving users’ health awareness and lower health risk for chronic diseases by addressing lifestyle changes such as regular exercise and social activity. The interoperability between the electronic health record system and telehealth solutions remains a hurdle for telehealth solutions to add value in health care. The hurdle is that doctors neither adjust health care plans nor diagnose based on data collected by telehealth solutions.
Mobile Apps Leveraged in the COVID-19 Pandemic in East and South-East Asia: Review and Content Analysis
Authors: Lee Bohee , Ibrahim Siti Aishah , Zhang Tiying 
Published: October 2021

BackgroundThe COVID-19 pandemic increased attention to digital tools to support governmental public health policies in East and South-East Asia. Mobile apps related to the COVID-19 pandemic continue to emerge and evolve with a wide variety of characteristics and functions. However, there is a paucity of studies evaluating such apps in this region, with most of the available studies conducted in the early days of the pandemic.ObjectiveThis study aimed to examine free apps developed or supported by governments in the East and South-East Asian region and highlight their key characteristics and functions. We also sought to interpret how the release dates of these apps were related to the commencement dates of other COVID-19 public health policies.MethodsWe systematically searched for apps in Apple App Store and Google Play Store and analyzed the contents of eligible apps. Mobile apps released or updated with COVID-19–related functions between March 1 and May 7, 2021, in Singapore, Taiwan, South Korea, China (mainland), Japan, Thailand, Hong Kong, Vietnam, Malaysia, Indonesia, and the Philippines were included. The CoronaNet Research Project database was also examined to determine the timeline of public health policy commencement dates in relation to the release dates of the included apps. We assessed each app’s official website, media reports, and literature through content analysis. Descriptive statistics were used to summarize relevant information gathered from the mobile apps using RStudio.ResultsOf the 1943 mobile apps initially identified, 46 were eligible, with almost 70% of the apps being intended for the general public. Most apps were from Vietnam (n=9, 20%), followed by Malaysia, Singapore, and Thailand (n=6 each, 13%). Of note, most apps for quarantine monitoring (n=6, 13%) were mandatory for the target users or a population subset. The most common function was health monitoring (32/46, 70%), followed by raising public health awareness (19/46, 41%) through education and information dissemination. Other functions included monitoring quarantine (12/46, 26%), providing health resources (12/46, 26%). COVID-19 vaccination management functions began to appear in parallel with vaccine rollout (7/46, 15%). Regarding the timing of the introduction of mobile solutions, the majority of mobile apps emerged close to the commencement dates of other public health policies in the early stages of the pandemic between March and April 2020.ConclusionsIn East and South-East Asia, most governments used mobile health apps as adjuncts to public health measures for tracking COVID-19 cases and delivering credible information. In addition, these apps have evolved by expanding their functions for COVID-19 vaccination.
Elimination of Stray Forces from Tire Dynamics Measurements or Beware the Backpath
Authors: Potts Gerald R. 
Published: October 2021

ABSTRACTThe forces that enter the mounted tire spindle of laboratory-type tire dynamics test machines include the following items: (1) direct tire-generated forces, tire nonuniformities, and tread pattern vibrations; (2) direct tire-transmitted rough road surface or cleat impact forces; (3) direct machine resonance-amplified versions of items 1 and 2; (4) machine frame backpath-transmitted versions of items 1–3; (5) dynamic loadcell crosstalk; (6) external noise from foundation vibrations; and (7) adjacent load station vibrations traveling through the machine frame. Although items 1 and 2 are sought in spindle vibration measurements, items 3–7 are also included in the mix and confound the measurement, confusing the analyst into thinking that machine properties are tire properties. Not only do items 3–6 not exist in vehicle operation but also comparison of results from one test machine to another can be an exercise in comparing machine to machine, not tire to tire. Tire dynamics measurements should simulate tires in roadway operation, not create a whole new set of problems that do not exist in vehicles. Elimination of item 7 paved the way to developing a tire failure warning system that operates on tire endurance test machines and can be adapted for operation on passenger vehicles to warn the driver of tire trouble. This article develops the theory of stray force measurement, describes a method for eliminating stray forces from experimental tire dynamics data, and provides experimental verification of the effectiveness of these methods.
Pengembangan Media Video Pembelajaran Materi Passing Bolavoli SMP Kelas VII
Authors: Simbolon Markus Dominique , Wahjoedi Wahjoedi , Spyanawati Ni Luh Putu 
Published: October 2021

Penelitian ini bertujuan untuk mengembangkan produk media pembelajaran berupa media video pembelajaran materi passing bolavoli untuk kelas VII SMP Negeri 4 Singaraja. Model pengembangan yang digunakan adalah model ADDIE meliputi 5 tahap yaitu: tahap Analisis (Analyze), Perancangan (Design), Pengembangan (Development), Penerapan (Implementation), dan Evaluasi (Evaluation). Metode pengumpulan data yang digunakan dalam penelitian ini adalah wawancara, pencatatan dokumen dan kuesioner. Prosedur validasi media video yaitu diawali dengan uji ahli isi mata pelajaran, ahli desain pembelajaran, ahli media pembelajaran. Data dianalisis dengan teknik analisis deskriptif kualitatif dan analisis deskriptif kuantitatif. Hasil penelitian berdasarkan tanggapan para ahli yaitu Ahli Isi Pembelajaran 90% (Sangat Baik), Ahli Media Pembelajaran 95% (Sangat Baik) dan Ahli Desain Pembelajaran 94% (Sangat Baik). Selama proses pengembangan, aspek yang diperbaiki adalah intensitas Penyempurnaan media pada video dari tanggapan para Ahli. Dari hasil diatas maka dapat dikatakan bahwa media video pembelajaran dengan model ADDIE materi passing bolavoli dapat dikatakan valid dan dapat digunakan untuk mendukunng proses pembelajaran atau penelitian lebih lanjut.
PENGARUH MODEL PEMBELAJARAN BERBANTUAN APLIKASI GOOGLE CLASSROOM TERHADAP HASIL BELAJAR BOLA BASKET
Authors: Rachman Harry Fitriyanto , Sudiana I Ketut , Wijaya Made Agus 
Published: October 2021

Penelitian ini bertujuan untuk mengetahui perbedaan hasil belajar bola basket antara siswa yang mengikuti model pembelajaran kooperatif tipe STAD dengan siswa yang mengikuti model pembelajaran PBL berbantuan aplikasi google classroom. Penelitian ini merupakan true experiment dengan rancangan The randomized pretest-posttest control group the same subjec design. Populasi penelitian seluruh siswa kelas VII SMP Negeri 1 Negara, sampel berjumlah 72 siswa. Penetapan sampel dengan teknik random sampling. Pengumpulan data menggunakan nilai keterampilan teknik dasar bola basket (dribbling, shoting, passing). Data yang diperoleh dianalisis menggunakan uji ANAVA. Pada kelompok yang dibelajarkan dengan model pembelajaran kooperatif tipe STAD berbantuan aplikasi google classroom diperoleh nilai rata-rata 86,2 dengan standar deviasi 1,35. Sedangkan pada kelompok yang dibelajarkan dengan model pembelajaran PBL berbantuan aplikasi google classroom. diperoleh nilai rata-rata 81,8 dengan standar deviasi 1,09. Angka signifikansi yang diperoleh melalui Uji t adalah 0,040. Berdasarkan hasil analisa data dan pembahasan, simpulan penelitian ini adalah bahwa terdapat perbedaan pengaruh hasil belajar bola basket pada siswa yang mengikuti pembelajaran kooperatif tipe STAD berbantuan aplikasi google classroom lebih tinggi dari pada siswa yang mengikuti model pembelajaran PBL berbantuan aplikasi google classroom.