bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Plasma Monocyte Trafficking-Related Molecules and Future Risk of Depression in Older Adults
Authors: Oh Dae Jong , Bae Jong Bin , Kim Tae Hui , Kwak Kyung Phil , Kim Bong Jo , Kim Shin Gyeom , Kim Jeong Lan , Moon Seok Woo , Park Joon Hyuk , Ryu Seung-Ho , Youn Jong Chul , Lee Dong Young , Lee Dong Woo , Lee Seok Bum , Lee Jung Jae , Jhoo Jin Hyeong , Han Ji Won , Kim Ki Woong 
Published: July 2021

Abstract

Background
The recruitment of monocytes to the brain plays an important role in the development of depression. However, the association between plasma biomarkers of monocyte trafficking and depression is unclear. This study is aimed to examine the effects of plasma monocyte chemoattractant protein 1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1) on the risk of depression.

Methods
Data were acquired from an ongoing prospective cohort study involving randomly sampled, community-dwelling Korean older adults, which has been followed every 2 years. We included 1539 euthymic older adults (age = 68.2 [5.6] years; 51.7% were women) without a history of major psychiatric disorders and dementia and neurological diseases. Geriatric psychiatrists diagnosed incident depression through a structured interview using the Korean version of the Mini-International Neuropsychiatric Interview.

Results
Depression had developed in 134 (8.7%) participants during the follow-up period of 5.7 (0.8) years. The high-plasma MCP-1 tertile group showed twofold higher risk of depression than the low-plasma MCP-1 tertile group (hazards ratio = 2.00, 95% confidence interval = 1.27–3.13, p = .003). The association between high levels of plasma MCP-1 and future risk of depression was significant in the middle-plasma ICAM-1 and VCAM-1 tertile groups; the high-plasma MCP-1 tertile group showed about fourfold higher risk of depression than the low-plasma MCP-1 tertile group.

Conclusions
Molecules involved in monocyte trafficking may be good candidates as diagnostic biomarkers and/or therapeutic targets for late-life depression.
Age, Sex, and Inhibitory Control: Identifying a Specific Impairment in Memorial, But Not Perceptual, Inhibition in Older Women
Authors: Siegel Alexander L M , Eich Teal S 
Published: July 2021

Abstract

Objectives
Declines in the ability to inhibit information, and the consequences to memory of unsuccessful inhibition, have been frequently reported to increase with age. However, few studies have investigated whether sex moderates such effects. Here, we examined whether inhibitory ability may vary as a function of age and sex, and the interaction between these two factors.

Method
202 older (mean age = 69.40 years) and younger (mean age =30.59 years) participants who had equivalent educational attainment and self-reported health completed 2 tasks that varied only in the time point at which inhibition should occur: either prior to, or after, encoding.

Results
While we did not find evidence for age or sex differences in inhibitory processes when information needed to be inhibited prior to encoding, when encoded information being actively held in working memory needed to be suppressed, we found that older women were particularly impaired relative to both younger women and men of either age group.

Discussion
These results provide further support for the presence of memorial inhibitory deficits in older age, but add nuance by implicating biological sex as an important mediator in this relationship, with it more difficult for older women to inhibit what was once relevant in memory.
Simultaneous retrieval of body and surface waves in the Dehdasht area, Iran, from the seismic ambient field and the observation of spurious artefacts
Authors: Riahi Ali , Shomali Zaher-Hossein , Obermann Anne , Kamayestani Ahmad 
Published: July 2021

SUMMARY
Recent developments in sensor technology have allowed for the low-cost deployment of dense seismic arrays which continuously record the seismic ambient noise field. Generally, the extraction of body waves from the seismic ambient noise field is more challenging than for surface waves, due to the dominant amplitude of the latter. In this study, we work with data from a dense seismic array deployment in the Dehdasht area, southwestern Iran. We show that by using the polarization properties of seismic waves, we can simultaneously retrieve both high frequency body waves and surface waves from the cross-correlated noise field. As a by-product of this study, we also observe high energy spurious artefacts, particularly those associated with the direct P-phases. Numerical simulations show that these artefacts are a consequence of an uneven distribution of noise sources, and are difficult to suppress during the simultaneous retrieval of body and surface waves.
Media coverage of COVID-19 health information in India: a content analysis
Authors: Gupta Medhavi , Keshri Vikash Ranjan , Konwar Pompy , Cox Katherine L , Jagnoor , and Jagnoor 
Published: July 2021

Summary
Effective response to the COVID-19 pandemic is dependent on individual understanding of the disease and compliance to prevention measures. Early media depiction of health information about COVID-19 may influence public perceptions and behaviour. Media should ensure coverage is relevant, timely and actionable to encourage individuals to respond appropriately. India has been particularly affected by a large COVID-19 caseload. We analysed online reporting in India to assess how well the media represented health information about COVID-19 as per the World Health Organization’s Strategic Risk Communications guidelines. This included media coverage of symptoms, transmission and prevention. We found that limited articles (18.8%) provided actionable suggestions to readers, including urging people to stay at home and social distance. Most articles were relevant as per WHO COVID-19 updates, accurately covering symptoms, risk factors for severe symptoms, transmission and prevention. However, 40% of media coverage of treatments options provided misleading information, such as suggesting plasma therapy or chloroquine, were effective. In addition, only 1.9% of articles included discussion of equity issues, where many prevention activities such as distancing are less applicable in lower-income households. Sixty-seven per cent of articles quoting sources of information quoted credible sources such as public health agencies and researchers. Media coverage also did not appear to reflect WHO updates in a timely manner, with most of the coverage preceding these updates. The findings show that Indian media should focus on actionable and relevant reporting that provides guidance for individual response. Media should also endeavour to report on evidence-based prevention and treatment options to avert the spread of misinformation.
Rise and demise: a case study of public health nutrition in Queensland, Australia, over three decades
Authors: Lee Amanda , Stubbs Christina , Leonard Dympna , Vidgen Helen , Minniecon Deanne , Dick Mathew , Cullerton Katherine , Herron Lisa 
Published: July 2021

Summary
This case study describes the delivery and achievements of the public health nutrition programme in Queensland, Australia, over more than three decades. Analysis of publicly available documents related to statewide nutrition policy and programmes from 1983 to 2014 identified key inputs and programme impacts and outcomes, including an increase in fruit and vegetable intake by 1.1 serves per person per day and rates of exclusive breastfeeding for the first 6 months quadrupled. Mapping factors and milestones against a framework on determinants of political priority highlighted correlation with effective nutrition promotion policy and practice. Identified enablers included the influence of policy champions and advocates, quality of governance, focus on whole-of-population approaches, and periods of political will and economic prosperity. Key barriers included changes of ideology with government leadership; lack of commitment to long-term implementation and evaluation; and limited recognition of and support for preventive health and nutrition promotion. The case study shows that a coordinated, well-funded, intersectoral approach to improve nutrition and prevent chronic disease and malnutrition in all its forms can be achieved and produce promising impacts at state level, but that sustained effort is required to secure and protect investment. Political support for long-term investment in nutrition is essential to reduce the high cost of all diet-related diseases. Public health leadership to better prepare for risks around political cycles, secure adequate resources for evaluation, and better communicate impacts and outcomes may help protect future investments and achievements.
A causal inference approach to compare leukaemia treatment outcome in the absence of randomization and with dependent censoring
Authors: Bernasconi Davide Paolo , Antolini Laura , Rossi Emanuela , Blanco-Lopez Jessica Giselle , Galimberti Stefania , Andersen Per Kragh , Valsecchi Maria Grazia 
Published: July 2021

Abstract

Background
One cause of poor outcomes in children of low-income countries affected by acute lymphoblastic leukaemia (ALL) is loss to follow-up due to abandonment of treatment. Assuming this type of loss to follow-up as independent censoring, as in standard Kaplan–Meier estimates, ignores the likely association of abandonment with biologic and socio-economic factors related to outcome. Moreover, when comparing treatment protocols adopted in different time periods, possible imbalances in patients’ characteristics must be considered. We aim to compare the outcome of children enrolled in two subsequent protocols for ALL treatment (2000–2007 and 2008–2015) in Honduras, taking both dependent censoring due to abandonment of treatment and imbalances between patient characteristics into account.

Methods
Marginal structural models based on inverse probability of treatment and censoring (IPTC) weighting allow the estimation of potential event-free survival (EFS) as if no abandonment of treatment occurred and the whole cohort was exposed, or not, to both protocols. An Aalen additive model and a logistic-regression model were used to build abandonment and treatment weights, respectively.

Results
The two protocols recruited 514 and 717 patients. Measured baseline covariates in both protocols were gender, age, white blood cell count, central nervous system involvement, tumour histology and socio-economic status. The potential EFS is slightly higher under the more recent protocol in the first 3 years but no difference is estimated in the long period [survival difference at 5 years (95% confidence interval) = 0.1% (−0.97%; 1.13%)]. Both protocols would allow reducing the event rate by 12–13% if there was no abandonment of treatment.

Conclusions
Using IPTC weighting, we found a similar potential effect of the two treatment protocols if the imbalance due to the different distribution of potential confounders and to abandonment of therapy was removed.
Factors associated with the use and composition of two-drug regimens in a large single-centre HIV cohort
Authors: de Lazzari Elisa , Gonzalez-Cordon Ana , Inciarte Alexy , Ugarte Ainoa , de la Mora Lorena , Martinez-Rebollar Maria , Laguno Montserrat , Ambrosioni Juan , Torres Berta , Mallolas Josep , Blanco Jose L , Miro Jose M , Martinez Esteban 
Published: July 2021

Abstract

Objectives
We aimed to assess the clinical characteristics associated with the use of two-drug regimens (2DRs) and the factors associated with specific antiretrovirals in 2DRs in a large single-centre HIV cohort.

Methods
Retrospective analysis of demographics, HIV characteristics and AIDS events, antiretroviral prescription, virological failure and genotypic resistance testing, and laboratory results from all adult people with HIV (PWH) prospectively followed at the Hospital Clinic of Barcelona who were receiving a 3DR or a 2DR in January 2020. We assessed factors associated with the probability of receiving 2DRs relative to three-drug regimens (3DRs) using a logistic regression model, controlling for age, sex and year of HIV diagnosis. The same methodology was applied to identify factors associated with the prescription of integrase inhibitor-based regimens or PI-based regimens among PWH receiving 2DRs.

Results
There were 3432 (88%) PWH receiving 3DRs and 463 (12%) receiving 2DRs. In the final adjusted model, ≥2 previous virological failures, previous resistance mutations, previous AIDS diagnosis, longer time on current regimen, higher total cholesterol or triglycerides and lower baseline haemoglobin were independent factors associated with 2DRs. The majority of 2DRs included an integrase inhibitor or/and a PI. We identified independent factors associated with the inclusion of integrase inhibitors (lower HDL cholesterol) or PIs (prior AIDS, prior genotypic resistance mutations and lower CD4/CD8 ratio) in the 2DR.

Conclusions
In this large single-centre HIV cohort, a worse cardiometabolic status or more archived resistance were key factors associated with inclusion of integrase inhibitors or PIs, respectively, in 2DRs.
Using a public database of Neisseria gonorrhoeae genomes to detect mutations associated with zoliflodacin resistance
Authors: Adamson Paul C , Lin Eric Y , Ha Sung-Min , Klausner Jeffrey D 
Published: July 2021

Abstract

Background
Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is an urgent global health threat. Zoliflodacin is a novel antibiotic undergoing clinical trials for the treatment of gonorrhoea. While there are limited data regarding zoliflodacin resistance in N. gonorrhoeae, three amino acid mutations have been associated with increased MICs of zoliflodacin.

Objectives
To determine the prevalence of three amino acid mutations associated with zoliflodacin resistance within a large, public database of nearly 13 000 N. gonorrhoeae genomes.

Methods
PathogenWatch is an online genomic epidemiology platform with a public database of N. gonorrhoeae genomes. That database was used to extract gyrB sequence data and a Basic Local Alignment Search Tool (BLAST) search was performed to identify any of the three amino acid mutations in GyrB that are associated with increased zoliflodacin MICs: D429N, K450N or K450T. As a control for the search methodology, all GyrA sequences were also extracted and S91F mutations were identified and compared with the PathogenWatch database.

Results
In total, 12 493 N. gonorrhoeae genomes from the PathogenWatch database were included. Among those genomes, none was identified that harboured any of the three mutations associated with increased zoliflodacin MICs. One genome was identified to have a mutation at position 429 in GyrB (D429V).

Conclusions
The findings suggest that the prevalence of the three mutations associated with zoliflodacin resistance in N. gonorrhoeae is very low. However, further research into the mechanisms of zoliflodacin resistance in N. gonorrhoeae is needed. Genomic epidemiology platforms like PathogenWatch can be used to enhance the global surveillance of AMR.
Rhabdomyosarcoma in the maxillary gingiva of a child patient
Authors: Komatsu Yuko , Kawai Tadashi , Miura Shoko , Takeda Yasunori , Yamada Hiroyuki 
Published: July 2021

Abstract
Rhabdomyosarcoma (RMS) is a rare, rapidly growing and aggressive malignant neoplasm mainly affecting children. However, mean age at the diagnosis of patients with gingival RMS is 26.9 years. A 12-year-old girl presented to our clinic with a chief complaint of trismus. The examination findings indicated a malignant tumor in the left maxillary gingiva. We performed a biopsy of the tumor, and the histopathological diagnosis was RMS. We report a rare case of primary RMS of the maxillary gingiva in a child patient.
Topological semantics of conservativity and interpretability logics
Authors: Iwata Sohei , Kurahashi Taishi 
Published: July 2021

AbstractWe introduce and develop a topological semantics of conservativity logics and interpretability logics. We prove the topological compactness theorem of consistent normal extensions of the conservativity logic $\textbf {CL}$ by extending Shehtman’s ultrabouquet construction method to our framework. As a consequence, we prove that several extensions of $\textbf {CL}$ such as $\textbf {IL}$, $\textbf {ILM}$, $\textbf {ILP}$ and $\textbf {ILW}$ are strongly complete with respect to our topological semantics.
Feats, Flops, and Free Lessons From NZ’s Response to the COVID-19 Pandemic
Authors: Manning Joanna M 
Published: July 2021

Abstract
Beginning from the first reports of COVID-19 out of China, this article provides a commentary on the actions taken by the Government of New Zealand in terms of nine themes—a national response with an elimination goal, speed, and comprehensiveness of the initial response; an evidence-based, science-led approach, prioritised on protecting lives; effective communication; leadership style which appealed to collective responsibility and attempted to de-politicise the Government’s response to the virus; flexibility of response characterised by ‘learning as you go’; oversight of coercive state powers, including a pragmatic response which attempted to defuse conflict and reserved use of ‘hard power’ to a last resort; deployment of public health interventions, and health system adaptations; the impact on Māori and marginalised communities; and economic protection and stimulus—to identify factors that might help explain why New Zealand’s pandemic response was successful and those which could have been managed better. The partially successful legal challenge brought to the four-and-a half week lockdown, the most stringent in the world, in Borrowdale v Director-General of Health, is also considered.
Indra: a public computationally accessible suite of cosmological N-body simulations
Authors: Falck Bridget , Wang Jie , Jenkins Adrian , Lemson Gerard , Medvedev Dmitry , Neyrinck Mark C , Szalay Alex S 
Published: July 2021

ABSTRACT
Indra is a suite of large-volume cosmological N-body simulations with the goal of providing excellent statistics of the large-scale features of the distribution of dark matter. Each of the 384 simulations is computed with the same cosmological parameters and different initial phases, with 10243 dark matter particles in a box of length 1 h−1 Gpc, 64 snapshots of particle data and halo catalogues, and 505 time-steps of the Fourier modes of the density field, amounting to almost a petabyte of data. All of the Indra data are immediately available for analysis via the SciServer science platform, which provides interactive and batch computing modes, personal data storage, and other hosted data sets such as the Millennium simulations and many astronomical surveys. We present the Indra simulations, describe the data products and how to access them, and measure ensemble averages, variances, and covariances of the matter power spectrum, the matter correlation function, and the halo mass function to demonstrate the types of computations that Indra enables. We hope that Indra will be both a resource for large-scale structure research and a demonstration of how to make very large data sets public and computationally accessible.
Efficient early stellar feedback can suppress galactic outflows by reducing supernova clustering
Authors: Smith Matthew C , Bryan Greg L , Somerville Rachel S , Hu Chia-Yu , Teyssier Romain , Burkhart Blakesley , Hernquist Lars 
Published: July 2021

ABSTRACT
We present a novel set of stellar feedback models, implemented in the moving-mesh code arepo, designed for galaxy formation simulations with near-parsec (or better) resolution. These include explicit sampling of stars from the IMF, allowing feedback to be linked to individual massive stars, an improved method for the modelling of H ii regions, photoelectric (PE) heating from a spatially varying FUV field and supernova feedback. We perform a suite of 32 simulations of isolated $M_\mathrm{vir} = 10^{10}\, \mathrm{M_\odot }$ galaxies with a baryonic mass resolution of $20\, \mathrm{M_\odot }$ in order to study the non-linear coupling of the different feedback channels. We find that photoionization (PI) and supernova feedback are both independently capable of regulating star formation to the same level, while PE heating is inefficient. PI produces a considerably smoother star formation history than supernovae. When all feedback channels are combined, the additional suppression of star formation rates is minor. However, outflow rates are substantially reduced relative to the supernova only simulations. We show that this is directly caused by a suppression of supernova clustering by the PI feedback, disrupting star-forming clouds prior to the first supernovae. We demonstrate that our results are robust to variations of our star formation prescription, feedback models and the baryon fraction of the galaxy. Our results also imply that the burstiness of star formation and the mass loading of outflows may be overestimated if the adopted star particle mass is considerably larger than the mass of individual stars because this imposes a minimum cluster size.
Review of synergic meteor observations: linking the results from cameras, ionosondes, infrasound and seismic detectors
Authors: Kereszturi Á , Barta V , Bondár I , Czanik Cs , Igaz A , Mónus P , Rezes D , Szabados L , Pál B D 
Published: July 2021

ABSTRACT
The joint evaluation of different meteor observation types supports a better understanding of both meteor phenomena and the terrestrial atmosphere. Two types of examples are presented in this work, linking ionospheric effects to specific meteors, with almost one-third of the meteors that emerged at high altitudes simultaneously recorded with an optical camera. Very few such observations have been realized as yet. With daytime fireballs, the recorded infrasound effect and the atmospheric blast produced shock-wave-related small earthquakes which were identified by a network of ground stations. An overview of these observational types highlights specific topics for which substantial improvements and discoveries are expected in the near future.
The loudest stellar heartbeat: characterizing the most extreme amplitude heartbeat star system
Authors: Jayasinghe T , Kochanek C S , Strader J , Stanek K Z , Vallely P J , Thompson Todd A , Hinkle J T , Shappee B J , Dupree A K , Auchettl K , Chomiuk L , Aydi E , Dage K , Hughes A , Shishkovsky L , Sokolovsky K V , Swihart S , Voggel K T , Thompson I B 
Published: July 2021

ABSTRACT
We characterize the extreme heartbeat star system MACHO 80.7443.1718 in the Large Magellanic Cloud using Transiting Exoplanet Survey Satellite (TESS) photometry and spectroscopic observations from the Magellan Inamori Kyocera Echelle (MIKE) and SOAR Goodman spectographs. MACHO 80.7443.1718 was first identified as a heartbeat star system in the All-Sky Automated Survey for SuperNovae (ASAS-SN) with $P_{\rm orb}=32.836\pm 0.008\, {\rm d}$. MACHO 80.7443.1718 is a young (∼6 Myr), massive binary, composed of a B0 Iae supergiant with $M_1 \simeq 35\, {\rm M}_\odot$ and an O9.5V secondary with $M_2 \simeq 16\, {\rm M}_\odot$ on an eccentric (e = 0.51 ± 0.03) orbit. In addition to having the largest variability amplitude amongst all known heartbeats stars, MACHO 80.7443.1718 is also one of the most massive heartbeat stars yet discovered. The B[e] supergiant has Balmer emission lines and permitted/forbidden metallic emission lines associated with a circumstellar disc. The disc rapidly dissipates at periastron that could indicate mass transfer to the secondary, but re-emerges immediately following periastron passage. MACHO 80.7443.1718 also shows tidally excited oscillations at the N = 25 and N = 41 orbital harmonics and has a rotational period of 4.4 d.