bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differentiation of accessions from the national lentil collection according to the level of drought resistance on a various concentrations PEG-6000 solution
Authors: Vus N. , Vasylenko A. O. , Shevchenko L. M. 
Published: October 2021

Aim. assessment of accessions from the lentil national collectionon the level of drought resistance on a PEG-6000 solution. Methods. The germination was carried out in growth plates on a filter paper bed at t = 21ºC for five days. A working solution of PEG-6000 with concentrations of 15.0% and 19.5% was used. The control was germinated in distilled water. The length of the shoot and root was measured and the level of depression of growth processes was calculated. Results. When germinating on a PEG-6000 solution with 19.5% concentration, the overwhelming number of accessions had depression indicators for shoots above 85% and above 60% for roots, and therefore it was not possible to isolate samples tolerant to the action of PEG-6000. When germinating on a 15% solution of PEG-6000, a wider range of variation was noted: depression in feature of “root length” ranged from 0% to 100%, “shoot length” - from 50% to 100%. The calculated Spearman's rank correlation coefficient confirms that shoots, in comparison with roots, are more sensitive to the action of osmotic in both variants of the experiment. Conclusions. The concentration of PEG-6000 was established for the selection of sources and the ranking of samples by drought resistance. Sources of drought resistance were identified from the studied sample – accessions subsp. microsperma: 8-MIL M 5 (UD0600007, France), UD0600028 (Ethiopia), Giza 9 (UD0600065, Egypt) and the accession-standard of drought resistance is Gornostepnaya (UD0600131, Armenia) subsp. microsperma.
Keywords: lentil, PEG-6000, concentration, sources of drought resistance.
Association of inherited thrombophilia gene polymorphism with sporadic and recurrent miscarriages
Authors: Chorna L. B. , Makukh H.V. , Zastavna D.V. , Zaganyach Ya.Yu. , Kolodiy O.I. , Kovtun O.V. 
Published: October 2021

Aim. Despite numerous scientific studies of possible causes of miscarriage, their etiology remains unclear in approximately 50% of cases. Investigate the prevalence of thrombophilia associated gene polymorphism FGB 455G/A, FII 20210 G/A, FV 1691G/A, ITGA2 807C/T, PAI-1 5G/4G and MTHFR 677C/T in women with sporadic and recurrent miscarriages. Methods. Group I included 35 women with sporadic miscarriage (SM), group II consisted of 57 women with recurrent miscarriage (RM) and 55 women of control group. Genetic testing was performed by PCR-RFLP. Results. In group I of women with SM the 455GA genotype of the FGB gene was more common and its presence in the genotype increases the risk of SM by 4 times and the presence of the 455A allele by 2 times. The Leiden mutation increases the risk of SM by 5 times. In II group of women with RM, the frequency of the 455 AA genotype of the FGB gene was more prevalent and the risk of RM was increased 2.5 times. It is shown that the risk of RM increases 4 times in the presence of the Leiden mutation. The 4G allele of the PAI-1 5G/4G polymorphism leads to a 2-fold increase in the risk of RM, and the presence of the 677TT genotype of the MTHFR gene increases the risk of RM by 3 times. Conclusions. Genetic factors of inherited thrombophilia alleles 455A of the FGB gene, 1691A of the FV gene, 4G of the PAI-1 gene and 677T of the MTHFR gene are alleles of significant risk of reproductive losses both sporadic and, to a greater extent, recurrent.
Keywords: sporadic miscarriage, recurrent.miscarriage, inherited thrombophilia, genetic polymorphism.
Protective properties of the nickel (II) complex with tryptophan
Authors: Shamilov E. N. , Abdullaev A. S. , Shamilli V. E. , Asgerova T.Y. , Gahramanova Sh. I. , Jalaladdinov F. F. 
Published: October 2021

Aim. The synthesized and characterized of the complex nickel (II) with tryptophan [NiL2 (H2O)2]; L = Trp. It is shown that the composition of the complex obtained depends on the ratio of the initial components. Methods. The composition and structure of the complex were studied by elemental, TG/DrTG-DTA analysis and IR spectroscopy. The method of IR showed that the ligand in the composition of the metal complex enter the neutral form and coordinate with the complexing agent through the nitrogen atom. Results. The results of thermogravimetric studies have shown that the final product of the thermal decomposition of all compound is metal oxide, respectively. Conclusions. Have been studied the biological properties – the toxicity has been evaluated, the influence of the complex on the resistance to hypoxia and ant radiation activity has been determined.
Keywords: tryptophan, nickel, tryptophan-metal complexes, amine groups, IR spectroscopy, thermogravimetry, toxicity, antiradiation activity.
Le système d’une île-entreprise en Guadeloupe (1940-1970)
Authors: Touchelay Marie-Christine 
Published: October 2021

Le changement de statut de son territoire avec la loi du 19 mars 1946 n’entraîne pas la fin de l’île-entreprise en Guadeloupe : jusqu’aux aux années 1980, elle reste sous l’emprise de l’industrie sucrière imposée comme seul outil de son développement économique. Comment s’explique cette longévité ? Quels en sont les acteurs et sur quels réseaux s’appuient-ils ? C’est l’objet de cet article.
Exploring the reach and impact of Gold and Green OA articles in hybrid journals
Authors: Monaghan Jess 
Published: October 2021

Does the type of open access that authors choose for their journal articles make a difference to the reach and impact of their research?
There are an increasing number of open access policies and mandates, such as Plan S’ policy which was introduced in 2021 for researchers who have been funded by certain members of cOAlition S, and UK Research and Innovation’s policy for UKRI-funded articles from April 2022 and books from 2024. However, some policies intend to exclude authors from selecting OA in hybrid journals by restricting funding only to those journals covered by Transformative Agreements. In addition, some policies seek to increase the availability of Green OA. These policies would seem to conflict with the potential benefits to authors of publishing Gold OA in hybrid journals.
In 2021, Springer Nature commissioned an analysis of 60,567 articles published in hybrid journals to explore the impact and reach of different types of articles (non-OA, Gold OA and Green OA). Our findings show not only that Gold OA articles attract more citations, more downloads, and higher Altmetric Attention Scores on average, compared with non-OA articles, but for the first time we will share evidence of a stronger advantage for Gold OA compared to Green OA. We will discuss the potential implications of these findings for authors, and for institutional and funder policy decisions.
Living the POSI Life
Authors: Fairhurst Vanessa , Pentz Ed 
Published: October 2021

Inclusive and efficient open research depends on foundational open scholarly infrastructure. It has become increasingly clear that there is a class of shared infrastructure to enable open research that should be open, community-governed, sustainable and trusted by the research community. However, to date there has been little clarity about how to assess, or even define, open scholarly infrastructure. As services that the scholarly community relies on and are essential to open research have been closed down or sold, it is imperative to understand and assess what constitutes open scholarly infrastructure.
The Principles of Open Scholarly Infrastructure (POSI) were conceived to ensure that the stakeholders of a community-led organization or initiative have a clear say in setting its agenda and priorities, and can carefully close it down and start an alternative if needed.
Join us in conversation with Ed Pentz, Executive Director of Crossref, to find out why the adoption of POSI is so significant for Crossref, how the organization currently meets the principles and what we will strive to do better, what this will mean for the future of Crossref and the wider community, and how you can get involved and learn more.
Study of Vitamin D Receptor Levels in Children with Immune Thrombocytopenic Purpura
Authors: Elkhalek Elnady Eman Abd , Mohamed Badraia Ibrahim , El-Haleim Hagag Adel Abd , Amr Hamam Sarah 
Published: October 2021

Background: Vitamin D, affecting many tissues and organs of the body. It exerts many of its effects through contact with Vitamin D receptor (VDR) It Is Important especially in immune system; Immune thrombocytopenia is one of the most common causes of symptomatic thrombocytopenia in children.
Aim: The main objective of our study was to study vitamin D receptor level in children with immune thrombocytopenic purpura and effect of vitamin D supplementation upon the response of the thrombocytopenia to conventional therapy of ITP.
Subjects and Methods: This is a case control study which included 30 ITP children, who would be attendants to Hematology and Oncology Unit, Pediatric Department, Tanta University Hospital in Egypt. This study would include also 30 apparently healthy children matched in age and sex as a control group. The duration of the study ranges from 6 to 12 months, for all patients and controls the following were done: complete blood count, bone marrow aspiration, serum level of Vitamin D receptors, serum calcium level, serum phosphorus level, serum alkaline phosphatase level and serum parathyroid hormone level.
Results: the results revealed that mean ± SD of Vitamin D receptors in case group is 132.43 ± 14.58 and there was statistical difference between groups regarding Vitamin D receptor. There was statistical difference between platelets count and Serum total Ca (mg/dl) with negative correlation, while there was no statistical difference between platelets count and Vitamin D receptor. There was statistically significant difference in platelets count in patient with ITP before and after conventional treatment and platelets count in patient with ITP under conventional treatment plus vitamin D supplementation.
Conclusion: VD receptors elevation is very common in ITP. Supplementing VD might diminish recurrence. Further research is needed.
A Study to Assess Prevalence of Nocturnal Enuresis and Its Associated Factor among School Going Children in Selected Rural Areas of Vadodara
Authors: Soni Nirali , Patel Rupal , Patel Jenisha , Patel Hetavi , Patel Hemali , Patel Harsh 
Published: October 2021

Background: Nocturnal enuresis, also called bedwetting, is involuntary urination while asleep after the age at which bladder control usually begins. Bedwetting in children and adults can result in emotional stress. Little is known about toilet training in pre-modern societies, but attitudes toward training in recent history have fluctuated substantially, and may vary across cultures and according to demographics. Treatments range from behavioral therapy, such as bedwetting alarms, to medication, such as hormone replacement, and even surgery such as urethral dilatation. Since most bedwetting is simply a developmental delay, most treatment plans aim to protect or improve self-esteem. Treatment guidelines recommend that the physician counsel the parents, warning about psychological consequences caused by pressure, shaming, or punishment for a condition children cannot control. Bedwetting is the most common childhood complaint. Children may face certain risks associated with training, such as slips or falling toilet seats, and toilet training may act in some circumstances as a trigger for abuse.
Aims: The aim of this study is to assess the prevalence of nocturnal enuresis and its associated factors among school going children in selected rural areas of Vadodara.
Methods: A descriptive research design was carried out for this study. The sample size of the study is 500. Participants were selected using stratified sampling technique. The tool is consists of two parts. First part consist of demographic data of the sample and second part consist of assertiveness self-assessment questionnaire.
Results: While assessing the associated factors of nocturnal enuresis in school going children, 15% children are having mild nocturnal enursesis,77%children are having moderate nocturnal enuresis and 8% children are having severe nocturnal enuresis. While assessing the association, there are three demographic variables age, sex and education of father has no significant association. So H0 has been rejected and H1 is accepted.
Conclusion: The present study concluded that majority of the children’s is having moderate level of nocturnal enuresis (77%) and minority of the children’s is having severe level of nocturnal enuresis (8%).
Anti-Cancer Activity of Gabapentin and Chiral Amino Acids-Based Hybrid-Peptides against MCF-7 Breast Cancer Cell-Line
Authors: Pansuriya Vraj B. , Kapadiya Khushal M. , Rathod Suryajitsinji L. , Prajapati Usha B. , Vavaiya Bhavin M. , Padariya Jasmin B. , Vaidya Foram U. , Pathak Chandramani , Parekh Hitesh M. 
Published: October 2021

Aims: Herein, we report the cytotoxicity of gabapentin-based peptides (11a-11j) using L-alanine and L-phenyl alanine chiral amino acids for peptide bond formation in ten efficient and straightforward steps. The in vitro MTT assays of derived molecules on the MCF-7 cell line (a human breast adenocarcinoma cell line) exhibited enhanced antitumor activity compared to the control (100% cell proliferation).
Methods: The ten steps synthetic methods were adapted for the synthesis of the Gabapentin-based peptide derivatives through BOC- deBOC methods and using EDC-HCl, DMAP and commercially available solvents. All the synthesized peptides were unambiguously characterized with the help of spectroscopic (IR, 1H NMR, 13C-NMR, mass spectra, and elemental) data analysis.
Results: The Compounds 11a, 11b, 11h,11i, and 11j showed a remarkable antiproliferative (cell death) activity, with % cell proliferation values ranging from 25-38 %.
Conclusion: The study showed that the compounds with some specific functionalities like, benzylic and trifluoromethyl functionality enhanced the potency with comparable %cell proliferation and cell death. Based on the findings in this work and their easily accessible molecular structures, compounds 11a and 11j are worthy of further biological investigations.
Model free adaptive control design for a tilt trirotor unmanned aerial vehicle with quaternion feedback: Theory and implementation
Authors: Gu Xun , Xian Bin , Li Jieqi 
Published: October 2021

SummaryThis article focuses on the attitude and altitude tracking control of the tilt trirotor unmanned aerial vehicle (UAV) which is subject to modeling uncertainties and unknown external disturbances. A novel model free adaptive controller is designed to achieve asymptotic tracking control of the UAV attitude and altitude channels. The control scheme is based on the data driven strategy, and relies on the input/output data to estimate the system dynamics online. Furthermore, the discrete sliding mode algorithm is combined to enhance the system robustness, and the quaternion feedback is employed to avoid the singularity associated with the attitude control design. The stability of closed‐loop system and the convergence of the tracking errors are proved. And real time flight experiments are preformed on a tilt trirotor UAV control testbed. The experimental results verify the effectiveness of the proposed control scheme and achieve a strong robustness with respect to the modeling uncertainties and unknown external disturbances.
Flexible Quasi‐Solid‐State High‐Performance Aqueous Zinc Ion Hybrid Supercapacitor with Water‐in‐Salt Hydrogel Electrolyte and N/P‐Dual Doped Graphene Hydrogel Electrodes
Authors: Deng Yongqi , Wang Hongfei , Zhang Kefu , Qiu Jun , Yan Lifeng 
Published: October 2021

AbstractAqueous zinc ion hybrid supercapacitors (ZHSCs) have attracted considerable attention owing to the bivalent nature, high abundance, and stability in the water‐based system of zinc. High energy density and superb power output can be achieved simultaneously by integrating a battery‐type electrode and a capacitive‐type electrode. However, there are still many issues that remain, including but not only hydrogen evolution reaction, dendrite growth, and dramatic capacity loss at low temperatures. Herein, a new type of hybrid “water‐in‐salt” hydrogel electrolyte based on 1 m Zn(CH3COO)2 and 20 m CH3COOK to expand the voltage window of ZHSCs to 0–2.1 V by suppressing the decomposition of water molecules is developed. The aqueous ZHSC delivers maximum energy of 100.2 Wh kg−1 at a power density of 487.5 W kg−1 based on the active materials and displays excellent cycling stability with 99.5% capacitance retention after 4000 cycles. Meanwhile, it is found that the assembled flexible quasi‐solid‐state ZHSC using the potassium polyacrylate/sodium carboxymethyl cellulose hydrogel electrolyte (containing 1 m Zn(CH3COO)2 and 20 m CH3COOK) also shows high‐performance (energy density of 106.5 Wh kg−1 at a power density of 383.3 W kg−1) with temperature adaptability at low temperature and wearable application potential with excellent energy storage performance.
Obesity Impairs Embryonic Myogenesis by Enhancing BMP Signaling within the Dermomyotome
Authors: Zhao Liang , Law Nathan C. , Gomez Noe A. , Son Junseok , Gao Yao , Liu Xiangdong , de Avila Jeanene M. , Zhu Mei‐Jun , Du Min 
Published: October 2021

AbstractObesity during pregnancy leads to adverse health outcomes in offspring. However, the initial effects of maternal obesity (MO) on embryonic organogenesis have yet to be thoroughly examined. Using unbiased single‐cell transcriptomic analyses (scRNA‐seq), the effects of MO on the myogenic process is investigated in embryonic day 9.5 (E9.5) mouse embryos. The results suggest that MO induces systematic hypoxia, which is correlated with enhanced BMP signaling and impairs skeletal muscle differentiation within the dermomyotome (DM). The Notch‐signaling effectors, HES1 and HEY1, which also act down‐stream of BMP signaling, suppress myogenic differentiation through transcriptionally repressing the important myogenic regulator MEF2C. Moreover, the major hypoxia effector, HIF1A, enhances expression of HES1 and HEY1 and blocks myogenic differentiation in vitro. In summary, this data demonstrate that MO induces hypoxia and impairs myogenic differentiation by up‐regulating BMP signaling within the DM, which may account for the disruptions of skeletal muscle development and function in progeny.
An LMNA synonymous variant associated with severe dilated cardiomyopathy: Case report
Authors: Gao Shanshan , Mumme‐Monheit Abigail , Chen Suet Nee , Spector Elaine B. , Slavov Dobromir , Baralle Francisco E. , Bristow Michael R. , Mestroni Luisa , Taylor Matthew R. G. ,   Familial Cardiomyopathy Registry
Published: October 2021

AbstractDilated cardiomyopathy (DCM) is one of the most common cardiac phenotypes caused by mutations of lamin A/C (LMNA) gene in humans. In our study, a cohort of 57 patients who underwent heart transplant for dilated cardiomyopathy was screened for variants in LMNA. We identified a synonymous variant c.936G>A in the last nucleotide of exon 5 of LMNA in a DCM family. Clinically, the LMNA variant carriers presented with severe familial DCM, conduction disease, and high creatine‐kinase level. The LMNA c.936G>A variant is novel and has not been reported in current genetic variant databases. Sanger sequencing results showed the presence of LMNA c.936G>A variant in the genomic DNA but not in the cDNA derived from one family member's heart tissue. Real‐time quantitative polymerase chain reaction showed significantly lower LMNA mRNA levels in the patient's heart compared to the controls, suggesting that the c.936G>A LMNA variant resulted in reduced mRNA and possibly lower protein expression of LMNA. These findings expand the understanding on the association between synonymous variant of LMNA and the molecular pathogenesis in DCM patients.
On channel estimation in cell‐free massive MIMO for spatially correlated channels with correlated shadowing under Rician fading
Authors: Amadid Jamal , Belhabib Abdelfettah , Zeroual Abdelouhab 
Published: October 2021

SummaryThis work addresses channel estimation (CE) in the uplink phase for a cell‐free massive multiple‐input multiple‐output system operating under the time division duplex protocol. Considering that, channels are spatially correlated under the Rician fading model, where the investigated model is composed of two components: deterministic and nondeterministic, with the deterministic component describing the line‐of‐sight paths and the nondeterministic component describing the non‐line‐of‐sight paths. Additionally, we dealt with correlated shadow fading that represents the most realistic situation. On the other hand, this work introduces a dynamic cooperation cluster framework in which the user is not served with the whole network ( i.e., all access points [APs]) but only the APs that present the best channel conditions regarding that user. In other words, this work proposes partial CE for each user because only APs with the best channel conditions are allowed to compute channel estimates. Consequently, we proposed partial channel estimators that perform the CE process with low complexity, namely, a partial minimum mean square error estimator and a partial element‐wise minimum mean square error estimator. In addition, a simple pilot assignment technique is proposed in order to reduce interference signals so that each user experiences low interference from other users. Furthermore, the computational complexity required by each estimator is derived, where it is represented by the number of complex multiplications that each estimator requires in each consistency block. Theoretical and simulated results are provided, where the performance of each estimator is evaluated and analyzed using the normalized mean‐square error metric.
Relationship between objectively measured physical activity on neuropathology and cognitive outcomes in older adults: Resistance versus resilience?
Authors: Memel Molly , Buchman Aron S. , Bennett David A. , Casaletto Kaitlin 
Published: October 2021

AbstractIntroductionPhysical activity (PA) is associated with better cognitive and brain health. However, it remains unclear whether PA relates to accumulation of disease pathology (“resistance”) or indirectly moderates adverse effects of pathology on cognition (“cognitive resilience”).MethodsFive hundred thirteen Rush Memory and Aging Project (MAP) decedents completed longitudinal actigraphy monitoring, cognitive testing, and neuropathological examination. Cross‐sectional models tested the relationship between average PA and pathology, and the moderating effect of baseline PA on the association between pathology and cognition. Longitudinal models examined whether changes in PA moderated associations between pathology and cognition.ResultsPA was negatively associated with Lewy body disease (LBD), but positively associated with Alzheimer's disease (AD) burdens. Baseline PA attenuated the association between cerebrovascular pathology and cognition, whereas longitudinal change in PA attenuated associations between AD, cerebral amyloid angiopathy, TAR DNA‐binding protein 43, and atherosclerosis on cognitive decline.DiscussionWhereas PA relates to “cognitive resilience” against cerebrovascular disease, AD, and other neuropathologies, “resistance” effects were limited.