bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic Consumer Liminality: Being Flexible in Precarious Times
Authors: Mimoun Laetitia , Bardhi Fleura 
Published: December 2021

Abstract
This study introduces the notion of chronic consumer liminality (CCL) defined as a recurrently activated state of transition experienced when engaging in frequent, multiple, and nonlinear consumer life transitions. CCL is characterized by (1) reoccurring transitions, (2) ongoing self-transformation, and (3) the embracing of precarity. We find evidence of CCL in a multimethod qualitative study of the flexible consumer lifestyle. CCL emerges as a response to the liquidification of society and the rise of a marketplace ideology of flexibility. CCL is manifested and managed through three CCL navigation processes: destabilizing consumption routines, liquidifying consumption, and asserting control over time and money. Thus, consumers experiencing CCL tend to prefer variety seeking and serendipity over routine even for mundane choices, access-based consumption across domains, and a productivity orientation toward free time. Three skills also facilitate CCL: resilient optimism, adaptability, and self-preservation. This study contributes to research on liminality, consumption in liminality, liquid consumption, and precarity. We conclude with the managerial implications of our framework.
A case of canalicular adenoma with anemia
Authors: Komatsu Yuko , Kawai Tadashi , Chiba Toshimi , Takeda Yasunori , Yamada Hiroyuki 
Published: December 2021

Abstract
An 81-year-old woman presented with bleeding from a soft elastic bulge on the right buccal mucosa. Her medical history included hypertension, chronic renal failure, hysterectomy and a goiter operation. Certain investigations, such as blood tests, which confirmed the minimum hemoglobin level of 5.3 g/dl, computed tomography and magnetic resonance imaging (MRI), were conducted. MRI revealed features confirming the presence of a tumor involving the right buccal mucosa with high signal in T2-enhanced image. Considering the provisional diagnosis and image findings, the tumor mass was excised and histopathological examination of the biopsy specimen confirmed the diagnosis of a canalicular adenoma. Under the diagnosis of various clinical departments, the anemic state of the patient might be chiefly attributed to the bleeding from the tumor. Herein, we report a rare case of a canalicular adenoma in the right buccal mucosa with anemia due to bleeding from the tumor.
A new look at local ultraluminous infrared galaxies: the atlas and radiative transfer models of their complex physics
Authors: Efstathiou A , Farrah D , Afonso J , Clements D L , González-Alfonso E , Lacy M , Oliver S , Papadopoulou Lesta V , Pearson C , Rigopoulou D , Rowan-Robinson M , Spoon H W W , Verma A , Wang L 
Published: December 2021

ABSTRACT
We present the ultraviolet to submillimetre spectral energy distributions (SEDs) of the HERschel Ultra Luminous Infrared Galaxy Survey (HERUS) sample of 42 local ultraluminous infrared galaxies (ULIRGs) and fit them with a Markov chain Monte Carlo code using the CYprus models for Galaxies and their NUclear Spectra (CYGNUS) radiative transfer models for starbursts, active galactic nucleus (AGN) tori, and host galaxy. The Spitzer IRS spectroscopy data are included in the fitting. Our Bayesian SED fitting method takes comparable time to popular energy balance methods but it is more physically motivated and versatile. All HERUS galaxies harbour high rates of star formation but we also find bolometrically significant AGN in all of the galaxies of the sample. We estimate the correction of the luminosities of the AGN in the ULIRGs due to the anisotropic emission of the torus and find that it could be up to a factor of ∼10 for nearly edge-on tori. We present a comparison of our results with the smooth torus model of Fritz et al. and the two-phase models of Siebenmorgen et al. and SKIRTOR. We find that the CYGNUS AGN torus models fit significantly better the SEDs of our sample compared to all other models. We find no evidence that strong AGN appear either at the beginning or end of a starburst episode or that starbursts and AGN affect each other. IRAS 01003−2238 and Mrk 1014 show evidence of dual AGNs in their SED fits, suggesting a minimum dual AGN fraction in the sample of 5 per cent.
On the validity of steady-state for nebular phase kilonovae
Authors: Pognan Quentin , Jerkstrand Anders , Grumer Jon 
Published: December 2021

ABSTRACT
The radioactively powered transient following a binary neutron star merger, known as a kilonova (KN), is expected to enter the steady-state nebular phase a few days after merger. Steady-state holds until thermal reprocessing time-scales become long, at which point the temperature and ionization states need to be evolved time-dependently. We study the onset and significance of time-dependent effects using the non-local thermodynamic equilibrium spectral synthesis code sumo. We employ a simple single-zone model with an elemental composition of Te, Ce, Pt, and Th, scaled to their respective solar abundances. The atomic data are generated using the Flexible Atomic Code (fac), and consist of energy levels and radiative transitions, including highly forbidden lines. We explore the KN evolution from 5 to 100 d after merger, varying ejecta mass and velocity. We also consider variations in the degree of electron magnetic field trapping, as well as radioactive power generation for alpha and beta decay (but omitting fission products). We find that the transition time, and magnitude of steady-state deviations are highly sensitive to these parameters. For typical KN ejecta, the deviations are minor within the time-frame studied. However, low density ejecta with low energy deposition show significant differences from ∼10 d. Important deviation of the ionization structure solution impacts the temperature by altering the overall line cooling. Adiabatic cooling becomes important at t ≥ 60 d which, in addition to the temperature and ionization effects, lead to the bolometric light-curve deviating from the instantaneous radioactive power deposited.
Chest computed tomography findings of adult patients with antimelanoma differentiation-associated protein 5 antibody-positive interstitial lung disease
Authors: Waseda Yuko , Johkoh Takeshi , Prosch Helmut , Nemec Stefan , Saeki Keigo , Watanabe Satoshi , Hamaguchi Yasuhito , Shiraki Akira , Muro Yoshinao , Yasui Masahide , Kasahara Kazuo , Herold Christian , Ishizuka Tamotsu 
Published: December 2021

ABSTRACT

Objectives
Interstitial lung disease (ILD) associated with the antimelanoma differentiation-associated protein 5 (anti-MDA5) antibody is a rapidly progressive disease that requires timely, aggressive treatment. However, prompt diagnosis is difficult due to the longer time required for antibody detection. This study described the computed tomography (CT) findings of anti-MDA5 antibody-positive ILD (anti-MDA5-ILD).

Methods
CT findings of 20 patients (7 men, 13 women; mean age, 53.6 ± 13.5 years) with anti-MDA5-ILD were retrospectively reviewed. All patients had clinical diagnoses of dermatomyositis, and 14 patients presented with amyopathic findings.

Results
Bilateral ground-glass attenuation, air-space consolidation, and reticular shadows were observed in 20 (100%), 15 (75%), and 3 (15%) patients, respectively. The spread of air-space consolidation was 6.0 ± 5.6% (mean ± standard deviation). Univariate analysis revealed that high Krebs von den Lungen-6, high spread of consolidation, low partial pressure of oxygen, and low forced vital capacity were significant predictors for poor survival. The final radiological diagnoses were nonspecific interstitial pneumonia and organising pneumonia (OP) in 2 (10%) and 16 (80%) patients, respectively. Further, 30% of OP patients showed fibrosis.

Conclusion
The characteristic CT findings of patients with anti-MDA5-ILD were ground-glass attenuation, air-space consolidation, and less reticulation. These CT findings were compatible with those of OP.
Efficacy and safety of filgotinib in combination with methotrexate in Japanese patients with active rheumatoid arthritis who have an inadequate response to methotrexate: Subpopulation analyses of 24-week data of a global phase 3 study (FINCH 1)
Authors: Tanaka Yoshiya , Matsubara Tsukasa , Atsumi Tatsuya , Amano Koichi , Ishiguro Naoki , Sugiyama Eiji , Yamaoka Kunihiro , Combe Bernard G , Kivitz Alan J , Bae Sang-Cheol , Keystone Edward C , Nash Peter , Matzkies Franziska , Bartok Beatrix , Pechonkina Alena , Kondo Akira , Ye Lei , Guo Ying , Tasset Chantal , Sundy John S , Takeuchi Tsutomu 
Published: December 2021

ABSTRACT

Objectives
Evaluate the efficacy and safety of the Janus kinase-1 inhibitor filgotinib in Japanese patients with rheumatoid arthritis (RA) and inadequate response to methotrexate (MTX).

Methods
Data from 147 Japanese patients in FINCH 1, a 52-week global Phase 3 study, were analysed up to 24 weeks. Patients received once-daily filgotinib 200 or 100 mg, biweekly adalimumab, or placebo, all with stable background MTX.

Results
In the Japanese population, American College of Rheumatology 20% response rates at Week 12 (primary endpoint) were 77.5%, 65.9%, 53.6%, and 36.8% for filgotinib 200 mg, filgotinib 100 mg, adalimumab, and placebo. Proportions of patients achieving Disease Activity Score with 28 joints &lt;2.6 at Week 24: filgotinib 200 mg, 65.0%; filgotinib 100 mg, 51.2%; adalimumab, 42.9%; and placebo, 5.3%. Incidence rates of serious infections: filgotinib 200 mg, 2.5%; filgotinib 100 mg, 0%; adalimumab, 10.7%; and placebo, 5.3%. Treatment-emergent laboratory abnormalities Grade ≥3 occurred in five (12.5%) filgotinib 200 mg, three (7.3%) filgotinib 100 mg, one (3.6%) adalimumab, and no placebo patients. No deaths were reported among Japanese patients.

Conclusions
Filgotinib once daily combined with MTX was effective and generally safe and well tolerated up to Week 24 in Japanese patients with RA and inadequate response to MTX.
Impaired function of rDNA transcription initiation machinery leads to derepression of ribosomal genes with insertions of R2 retrotransposon
Authors: Fefelova Elena A , Pleshakova Irina M , Mikhaleva Elena A , Pirogov Sergei A , Poltorachenko Valentin A , Abramov Yuri A , Romashin Daniil D , Shatskikh Aleksei S , Blokh Roman S , Gvozdev Vladimir A , Klenov Mikhail S 
Published: December 2021

Abstract
Eukaryotic genomes harbor hundreds of rRNA genes, many of which are transcriptionally silent. However, little is known about selective regulation of individual rDNA units. In Drosophila melanogaster, some rDNA repeats contain insertions of the R2 retrotransposon, which is capable to be transcribed only as part of pre-rRNA molecules. rDNA units with R2 insertions are usually inactivated, although R2 expression may be beneficial in cells with decreased rDNA copy number. Here we found that R2-inserted rDNA units are enriched with HP1a and H3K9me3 repressive mark, whereas disruption of the heterochromatin components slightly affects their silencing in ovarian germ cells. Surprisingly, we observed a dramatic upregulation of R2-inserted rRNA genes in ovaries lacking Udd (Under-developed) or other subunits (TAF1b and TAF1c-like) of the SL1-like complex, which is homologues to mammalian Selective factor 1 (SL1) involved in rDNA transcription initiation. Derepression of rRNA genes with R2 insertions was accompanied by a reduction of H3K9me3 and HP1a enrichment. We suggest that the impairment of the SL1-like complex affects a mechanism of selective activation of intact rDNA units which competes with heterochromatin formation. We also propose that R2 derepression may serve as an adaptive response to compromised rRNA synthesis.
Plasticity of bud outgrowth varies at cauline and rosette nodes in Arabidopsis thaliana
Authors: Fichtner Franziska , Barbier Francois F , Kerr Stephanie C , Dudley Caitlin , Cubas Pilar , Turnbull Colin , Brewer Philip B , Beveridge Christine A 
Published: December 2021

Abstract
Shoot branching is a complex mechanism in which secondary shoots grow from buds that are initiated from meristems established in leaf axils. The model plant Arabidopsis (Arabidopsis thaliana) has a rosette leaf growth pattern in the vegetative stage. After flowering initiation, the main stem elongates with the top leaf primordia developing into cauline leaves. Meristems in Arabidopsis initiate in the axils of rosette or cauline leaves, giving rise to rosette or cauline buds, respectively. Plasticity in the process of shoot branching is regulated by resource and nutrient availability as well as by plant hormones. However, few studies have attempted to test whether cauline and rosette branching are subject to the same plasticity. Here, we addressed this question by phenotyping cauline and rosette branching in three Arabidopsis ecotypes and several Arabidopsis mutants with varied shoot architectures. Our results showed no negative correlation between cauline and rosette branch numbers in Arabidopsis, demonstrating that there is no tradeoff between cauline and rosette bud outgrowth. Through investigation of the altered branching pattern of flowering pathway mutants and Arabidopsis ecotypes grown in various photoperiods and light regimes, we further elucidated that the number of cauline branches is closely related to flowering time. The number of rosette branches has an enormous plasticity compared with cauline branches and is influenced by genetic background, flowering time, light intensity, and temperature. Our data reveal different levels of plasticity in the regulation of branching at rosette and cauline nodes, and promote a framework for future branching analyses.
On the Logicality of Truth
Authors: Fujimoto Kentaro 
Published: December 2021

Abstract
Deflationism about truth describes truth as a logical notion. In the present paper, I explore the implication of the alleged logicality of truth from the perspective of axiomatic theories of truth, and argue that the deflationist doctrine of the logicality of truth gives rise to two types of self-undermining arguments against deflationism, which I call the conservativeness argument from logicality and the topic-neutrality argument.
Competition Links and Stock Returns
Authors: Eisdorfer Assaf , Froot Kenneth , Ozik Gideon , Sadka Ronnie 
Published: December 2021

Abstract
This paper demonstrates that value-relevant information about a firm appearing in regulatory disclosures of other firms is overlooked by investors. Firms highly mentioned in the 10-K competition section of other firms tend to outperform with risk-adjusted returns of up to 9$\%$ annually. Outperformance is concentrated in firms whose competition references are made in the context of targeting rather than admiration. Consistent with investor inattention, abnormal returns stem from cross-sector competition mentions as well as firms with low-analyst coverage. Moreover, highly mentioned firms exhibit improved fundamentals in subsequent years, further signifying they are underpriced.
Comparison of treatment retention of originator vs biosimilar products in clinical rheumatology practice in Sweden
Authors: Di Giuseppe Daniela , Lindstrom Ulf , Bower Hannah , Delcoigne Bénédicte , Frisell Thomas , Chatzidionysiou Katerina , Sjöwall Christopher , Lindqvist Elisabet , Askling Johan 
Published: December 2021

Abstract

Objectives
To compare treatment retention between biosimilars and their originator products among first starters (etanercept, infliximab, adalimumab and rituximab), as well as after non-medical switch.

Methods
Patients with rheumatic diseases starting, for the first time, an originator or biosimilar etanercept, infliximab, adalimumab or rituximab were identified in the national Swedish Rheumatology Quality Register. Moreover, patients switching from an originator to its biosimilar were identified and individually matched to patients continuing on the originator. One-year treatment retention was calculated and hazard ratios (HR) for discontinuation with 95% CIs were estimated, adjusting for comorbidities and socio-economic factors.

Results
In total, 21 443 first treatment courses were identified. The proportion of patients still on the drug at 1 year and the HR for discontinuation revealed no differences across adalimumab (Humira, Imraldi, Amgevita and Hyrimoz) nor across rituximab products (Mabthera, Ritemvia/Truxima and Rixathon). The proportions on the drug at 1 year were similar for Benepali (77%) and Enbrel (75%) and the adjusted HR for Benepali compared with Enbrel was 0.91 (95% CI 0.83, 0.99). For infliximab, the proportion still on the drug at 1 year was 67% for Remicade and 66% for Remsima/Inflectra and the HR compared with Remicade was 1.16 (95% CI 1.02, 1.33). Among 2925 patients switching from an originator drug to one of its biosimilars, we noted no statistically significant or clinically relevant differences in drug survival compared with those who remained on originator therapy.

Conclusion
This large observational study supports the equivalence of biologic DMARD biosimilar products and originators when used in routine rheumatology care.
Balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension
Authors: Taweel Helwa , Haddadin Ihab , Heresi Gustavo 
Published: December 2021

ABSTRACT
Chronic thromboembolic pulmonary hypertension (CTEPH) remains significantly underdiagnosed in patients with a history of pulmonary embolism. These patients complain of persistent shortness of breath and present with hypoxemia despite proper anticoagulation. Further investigation reveals evidence of right ventricular dysfunction on echocardiogram, which progresses to right heart failure. CTEPH is associated with a significant increase in patient morbidity and mortality if left untreated. This article offers an approach for the timely recognition of this condition, in addition to suggesting a management protocol with an emphasis on the role of interventional radiology and balloon pulmonary angioplasty.
Impact of Mentoring on Academic Career Success for Women in Medicine: A Systematic Review
Authors: Shen Mary R. , Tzioumis Emma , Andersen Elizabeth , Wouk Kathryn , McCall Rebecca , Li Winston , Girdler Susan , Malloy Erin 
Published: December 2021

Purpose
Research has shown that barriers to career success in academic medicine disproportionately affect women. These barriers include inadequate mentoring, which may perpetuate the underrepresentation of women in senior leadership positions. The purpose of this review was to summarize the qualitative and quantitative evidence of the impact of mentoring on women’s career outcomes and to inform future interventions to support the promotion and retention of women in academic medicine.

Method
The authors conducted a systematic review of original research published in English-language, peer-reviewed journals through March 20, 2020. Search terms related to mentorship, women, and academic medicine. The authors searched MEDLINE, Embase, Scopus, Current Contents Connect via Web of Science, Cochrane Library, and PsycINFO. They excluded studies not specifically addressing women and those without gender-stratified outcomes. They extracted and analyzed the following data: study design, population, sample size, response rate, participant age, percentage of women, mentoring prevalence, and outcomes.

Results
Of 2,439 citations identified, 91 studies met the inclusion criteria, including 65 quantitative and 26 qualitative studies. Mentoring was associated with objective and subjective measures of career success. Women perceived mentorship to be more valuable to their career development yet were more likely to report having no mentor. Additionally, women were more likely to report lower levels of research productivity, less career satisfaction, and greater barriers to promotion. Qualitative results indicated that women had less access to informal mentoring and family responsibilities had a greater effect on their career outcomes. Professional networking, female mentors, and relational aspects of mentoring were common themes.

Conclusions
This review examined gender disparities in mentoring and the impact on research productivity, promotion success, and career satisfaction for women in academic medicine. Institution-supported mentoring programs are needed to facilitate identification of appropriate mentors and promotion of a more equitable academic career environment for women.
Differential Item Functioning Analysis of United States Medical Licensing Examination Step 1 Items
Authors: Rubright Jonathan D. , Jodoin Michael , Woodward Stephanie , Barone Michael A. 
Published: December 2021

Purpose
Previous studies have examined and identified demographic group score differences on United States Medical Licensing Examination (USMLE) Step examinations. It is necessary to explore potential etiologies of such differences to ensure fairness of examination use. Although score differences are largely explained by preceding academic variables, one potential concern is that item-level bias may be associated with remaining group score differences. The purpose of this 2019–2020 study was to statistically identify and qualitatively review USMLE Step 1 exam questions (items) using differential item functioning (DIF) methodology.

Method
Logistic regression DIF was used to identify and classify the effect size of DIF on Step 1 items meeting minimum sample size criteria. After using DIF to flag items statistically, subject matter expert (SME) review was used to identify potential reasons why items may have performed differently between racial and gender groups, including characteristics such as content, format, wording, context, or stimulus materials. USMLE SMEs reviewed items to identify the group difference they believed was present, if any; articulate a rationale behind the group difference; and determine whether that rationale would be considered construct relevant or construct irrelevant.

Results
All identified DIF rationales were relevant to the constructs being assessed and therefore did not reflect item bias. Where SME-generated rationales aligned with statistical differences (flags), they favored self-identified women on items tagged to women’s health content categories and were judged to be construct relevant.

Conclusions
This study did not find evidence to support the hypothesis that group-level performance differences beyond those explained by prior academic performance variables are driven by item-level bias. Health professions examination programs have an obligation to assess for group differences, and when present, investigate to what extent, if any, measurement bias plays a role.
Gout and the COVID-19 pandemic
Authors: Tai Vicky , Robinson Philip C. , Dalbeth Nicola 
Published: December 2021

Purpose of review
This review gives an overview of recently published articles on COVID-19 and gout.

Recent findings
People with gout are likely to be at an increased risk of poor outcomes after COVID-19 infection due to comorbid cardiometabolic conditions. The effects of chronic hyperuricemia on trained immunity, and the hyperinflammatory state induced by gout itself may also play a role. Frequent courses of glucocorticoids for gout flares may be associated with adverse outcomes after COVID-19 infection and reduced immunogenicity to the COVID-19 vaccination. Similarities between the pathophysiology of gout flares and the dysregulated inflammatory response of severe COVID-19 have been identified. Medications used in the treatment of gout, including colchicine and interleukin-1 inhibitors, have shown promise in the treatment of COVID-19 in clinical trials. Overall, the COVID-19 pandemic has had a negative impact on gout care, with patients reporting more difficulty with disease control, accessing medications and healthcare, and poorer quality of life.

Summary
The COVID-19 pandemic has created many challenges for people with gout. At present, there is a lack of guidance on the management of gout during the pandemic and paucity of research assessing outcomes of COVID-19 infection in people with gout.