bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Transfer on Outcomes in Burns
Authors: Bodily Nathan E , Bruenderman Elizabeth H , Bhutiani Neal , The Selena , Schucht Jessica E , Bozeman Matthew C 
Published: June 2021

Abstract
Patients with burn injuries are often initially transported to centers without burn capabilities, requiring subsequent transfer to a higher level of care. This study aimed to evaluate the effect of this treatment delay on outcomes. Adult burn patients meeting American Burn Association criteria for transfer at a single burn center were retrospectively identified. A total of 122 patients were evenly divided into two cohorts—those directly admitted to a burn center from the field vs those transferred to a burn center from an outlying facility. There was no difference between the transfer and direct admit cohorts with respect to age, percentage of total body surface area burned, concomitant injury, or intubation prior to admission. Transfer patients experienced a longer median time from injury to burn center admission (1 vs 8 hours, P &lt; .01). Directly admitted patients were more likely to have inhalation burn (18 vs 4, P &lt; .01), require intubation after admission (10 vs 2, P = .03), require an emergent procedure (18 vs 5, P &lt; .01), and develop infectious complications (14 vs 5, P = .04). There was no difference in ventilator days, number of operations, length of stay, or mortality. The results suggest that significantly injured, high acuity burn patients were more likely to be immediately identified and taken directly to a burn center. Patients who otherwise met American Burn Association criteria for transfer were not affected by short delays in transfer to definitive burn care.
Occurrence of Multiple-Drug Resistance Bacteria and Their Antimicrobial Resistance Patterns in Burn Infections from Southwest of Iran
Authors: Hashemzadeh Mohammad , Heydari Reza , Asareh Zadegan Dezfuli Aram , Saki Morteza , Meghdadi Hossein , Bakhtiyariniya Pejman 
Published: June 2021

Abstract
Burn infection continues to be a major issue of concern globally and causes more harm to developing countries. This study aimed to identify the aerobic bacteriological profiles and antimicrobial resistance patterns of burn infections in three hospitals in Abadan, southwest Iran. The cultures of various clinical samples obtained from 325 burn patients were investigated from January to December 2019. All bacterial isolates were identified based on the standard microbiological procedures. Antibiotic susceptibility tests were performed according to the CLSI. A total of 287 bacterial species were isolated from burn patients. Pseudomonas aeruginosa was the most frequent bacterial isolate in Gram-negative bacteria and S. epidermidis was the most frequent species isolated in Gram-positive bacteria. The maximum resistance was found to ampicillin, gentamicin, ciprofloxacin, while in Gram-negative bacteria, the maximum resistance was found to imipenem, gentamicin, ciprofloxacin, ceftazidime, and amikacin. The occurrence of multidrug resistance phenotype was as follows: P. aeruginosa (30.3%), Enterobacter spp (11.1%), Escherichia coli (10.5%), Citrobacter spp (2.1%), S. epidermidis (2.8%), S. aureus, and S. saprophyticus (0.7%). Owing to the diverse range of bacteria that cause burn wound infection, regular investigation, and diagnosis of common bacteria and their resistance patterns is recommended to determine the proper antibiotic regimen for appropriate therapy.
Sequential activation of uterine epithelial IGF1R by stromal IGF1 and embryonic IGF2 directs normal uterine preparation for embryo implantation
Authors: Zhou Chan , Lv Meiying , Wang Peike , Guo Chuanhui , Ni Zhangli , Bao Haili , Tang Yedong , Cai Han , Lu Jinhua , Deng Wenbo , Yang Xiaoyu , Xia Guoliang , Wang Haibin , Wang Chao , Kong Shuangbo 
Published: June 2021

Abstract
Embryo implantation in both humans and rodents is initiated by the attachment of a blastocyst to the uterine epithelium. For blastocyst attachment, the uterine epithelium needs to transform at both the structural and molecular levels first, and then initiate the interaction with trophectoderm. Any perturbation during this process will result in implantation failure or long-term adverse pregnancy outcomes. Endocrine steroid hormones, which function through nuclear receptors, combine with the local molecules produced by the uteri or embryo to facilitate implantation. The insulin-like growth factor (IGF) signaling has been reported to play a vital role during pregnancy. However, its physiological function during implantation remains elusive. This study revealed that mice with conditional deletion of Igf1r gene in uteri suffered from subfertility, mainly due to the disturbed uterine receptivity and abnormal embryo implantation. Mechanistically, we uncovered that in response to the nidatory estrogen on D4 of pregnancy, the epithelial IGF1R, stimulated by the stromal cell-produced IGF1, facilitated epithelial STAT3 activation to modulate the epithelial depolarity. Furthermore, embryonic derived IGF2 could activate both the epithelial ERK1/2 and STAT3 signaling through IGF1R, which was critical for the transcription of Cox2 and normal attachment reaction. In brief, our data revealed that epithelial IGF1R was sequentially activated by the uterine stromal IGF1 and embryonic IGF2 to guarantee normal epithelium differentiation during the implantation process.
Pediatric Kawasaki Disease Trends Prior to and During COVID-19 Outbreak in Singapore
Authors: Chong Chia Yin , Tan Natalie Woon Hui , Yung Chee Fu , Nadua Karen , Kam Kai Qian , Li Jiahui , Thoon Koh Cheng 
Published: June 2021

Abstract
Kawasaki disease (KD, typical/atypical/partial) admissions (n = 644) were surveyed from 2017 to 2020 and compared to urinary tract infection (UTI) admissions and COVID-19 in 2020. KD admissions decreased by 27% and median KD age decreased in 2020, whereas UTI admissions remained steady. KD admissions showed a seasonality with a peak in April and nadir in February-March. All KD/KD-related pediatric intensive care unit cases tested negative for COVID-19, and no multisystem inflammatory syndrome in children was found.
Comparative toxicity of rod-shaped nano-CeO2 and nano-CePO4 to lettuce
Authors: Liu Yabo , Ma Yuhui , Jiao Chunlei , Liu Mengyao , Luo Wenhe , Dong Chaonan , Fan Shixian , He Xiao , Yang Fang , Zhang Zhiyong 
Published: June 2021

AbstractThe influence of morphology on the biological effects of nanomaterials (NMs) has not been well understood. In the present study, we compared the phytotoxicity of rod-shaped nano-cerium dioxide (R-CeO2) and nano-cerium phosphate (R-CePO4) to lettuce plants. The results showed that R-CeO2 significantly inhibited the root elongation of lettuce, induced oxidative damages, and caused cell death, while R-CePO4 was nontoxic to lettuce. The different distribution and speciation of Ce in plant tissues were determined by transmission electron microscopy (TEM) and X-ray absorption near edge spectroscopy (XANES) combined with linear combination fitting (LCF). The results showed that in the R-CeO2 group, part of Ce was transformed from Ce(IV) to Ce(III), while only Ce(III) was present in the R-CePO4 group. When interacting with plants, R-CeO2 is easier to be dissolved and transformed than R-CePO4, which might be the reason for their different phytotoxicity. Although both are Ce-based NMs and have the same morphology, the toxicity of R-CeO2 seems to come from the released Ce3+ ions rather than its shape. This research emphasizes the importance of chemical composition and reactivity of NMs to their toxicological effects.
Reimagining pilocytic astrocytomas in the context of pediatric low-grade gliomas
Authors: Milde Till , Rodriguez Fausto J , Barnholtz-Sloan Jill S , Patil Nirav , Eberhart Charles G , Gutmann David H 
Published: June 2021

Abstract
Pediatric low-grade gliomas (pLGGs) are the most common brain tumor in children and are associated with lifelong clinical morbidity. Relative to their high-grade adult counterparts or other malignant childhood brain tumors, there is a paucity of authenticated preclinical models for these pLGGs and an incomplete understanding of their molecular and cellular pathogenesis. While large-scale genomic profiling efforts have identified the majority of pathogenic driver mutations, which converge on the MAPK/ERK signaling pathway, it is now appreciated that these events may not be sufficient by themselves for gliomagenesis and clinical progression. In light of the recent World Health Organization reclassification of pLGGs, and pilocytic astrocytoma (PA), in particular, we review our current understanding of these pediatric brain tumors, provide a conceptual framework for future mechanistic studies, and outline the challenges and pressing needs for the pLGG clinical and research communities.
Trends in Antibiotic Use in United States Hospitals During the Coronavirus Disease 2019 Pandemic
Authors: Rose Ashley N , Baggs James , Wolford Hannah , Neuhauser Melinda M , Srinivasan Arjun , Gundlapalli Adi V , Reddy Sujan , Kompaniyets Lyudmyla , Pennington Audrey F , Grigg Cheri , Kabbani Sarah 
Published: June 2021

Abstract
We described antibiotic use among inpatients with coronavirus disease 2019 (COVID-19). Most COVID-19 inpatients received antibiotic therapy. We also described hospital-wide antibiotic use during 2020 compared with 2019, stratified by hospital COVID-19 burden. Although total antibiotic use decreased between years, certain antibiotic use increased with higher COVID-19 burden.
Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 Isolates
Authors: Moustafa Ahmed M , Bianco Colleen , Denu Lidiya , Ahmed Azad , Coffin Susan E , Neide Brandy , Everett John , Reddy Shantan , Rabut Emilie , Deseignora Jasmine , Feldman Michael D , Rodino Kyle G , Bushman Frederic , Harris Rebecca M , Chang Mell Josh , Planet Paul J 
Published: June 2021

Abstract
We report the genome of a B.1.1.7+E484K severe acute respiratory syndrome coronavirus 2 from Southeastern Pennsylvania and compare it with all high-coverage B.1.1.7+E484K genomes (n = 235) available. Analyses showed the existence of at least 4 distinct clades of this variant circulating in the United States and the possibility of at least 59 independent acquisitions of the E484K mutation.
Physical Possibility and Determinate Number Theory
Authors: Berry Sharon 
Published: June 2021

ABSTRACTIt is currently fashionable to take Putnamian model-theoretic worries seriously for mathematics, but not for discussions of ordinary physical objects and the sciences. However, I will argue that (under certain mild assumptions) merely securing determinate reference to physical possibility suffices to rule out the kind of nonstandard interpretations of our number talk Putnam invokes. So, anyone who accepts determinate reference to physical possibility should not reject determinate reference to the natural numbers on Putnamian model-theoretic grounds.
The Filipino community pantries: a manifestation of the spirituality of ‘Alay Kapwa’ in the time of the pandemic
Authors: Canete Jonathan James O , Rocha Ian Christopher , Dolosa Jian Dennis P 
Published: June 2021

Abstract
The coronavirus disease of 2019 pandemic has brought not only disaster to humanity but also the best in each human individual. Filipinos, in a special way, have exhibited the inherent greatness of the human person in the construction of the community pantries where people who can sustain their needs in time of pandemic would donate some provisions to those who are needy. The establishment of various community pantries across the Philippines embodies the spirituality of ‘Alay Kapwa’, a spirituality that connects people together especially in time of crisis to be persons for others rather than harboring an unnaturalistic human and primitive attitude of self-centeredness.
Public health impact of the COVID-19 pandemic on the emergency healthcare system
Authors: Stirparo G , Oradini-Alacreu A , Migliori M , Villa G F , Botteri M , Fagoni N , Signorelli C , Sechi G M , Zoli A 
Published: June 2021

AbstractBackgroundThe Lombardy region has been the Italian region most affected by the coronavirus disease 2019 (COVID-19) pandemic in 2020. The emergency healthcare system was under deep stress throughout the past year due to the admission of COVID-19 patients to the emergency department (ED) and had to be thoroughly reorganized.MethodsWe performed a retrospective descriptive analysis of patients admitted into the ED recorded in the Lombardy online regional portal called EUOL (Emergenza e Urgenza OnLine). We compared the data registered in the EUOL with the patients admitted to the EDs from 1 January 2019 to 31 December 2019 and from 1 January 2020 to 31 December 2020.ResultsThe number of admissions to the ED decreased by 32.5% in 2020 compared with 2019, reaching the lowest number in March and April. However, the percentage of patients hospitalized after ED significantly increased in 2020 compared with 2019 (P &lt; 0.0001), reflecting the management of patients with a more severe clinical condition. More patients arrived at the ED by ambulance in 2020 (21.7% in 2020 versus 15.1% in 2019; P &lt; 0.0001), particularly during March and April.ConclusionsThis analysis showed the importance of monitoring the pandemic’s evolution in order to treat more critically ill patients, despite a lower number of patients.
Assessing the psychometric properties of the PROMIS sleep measures in persons with psychosis
Authors: Savage Christina L G , Orth Ryan D , Jacome Anyela M , Bennett Melanie E , Blanchard Jack J 
Published: June 2021

Abstract
An accumulation of research has indicated that persons with psychotic disorders experience a variety of sleep disturbances. However, few studies have examined the psychometric properties of sleep assessments that are utilized in this population. We conducted two studies to examine the reliability and validity of the PROMISTM Sleep Disturbance and Sleep-Related Impairment scales in outpatient samples of persons with psychosis. In Study 1, we examined the internal consistency and convergent validity of the PROMIS sleep scales in individuals with various psychotic disorders (N = 98) and healthy controls (N = 22). The PROMIS sleep scales showed acceptable internal consistency and convergent validity in both healthy controls and individuals with psychotic disorders. In addition, replicating prior research, the PROMIS scales identified greater sleep disturbance and sleep-related impairment in participants with psychotic disorders compared to healthy controls. In Study 2, we examined the test-retest reliability (M = 358 days) of the PROMIS sleep scales in a subset (N = 37) of persons with psychotic disorders who previously participated in Study 1. We also assessed the relation between these self-report measures and actigraph sleep parameters. The results showed that PROMIS sleep measures demonstrated modest temporal stability in the current sample. Contrary to our hypothesis, there was a lack of correspondence between these scales and actigraph sleep parameters. Overall, these findings indicate that the PROMIS sleep scales are psychometrically sound measures for populations with psychosis and highlight the importance of utilizing a multi-method approach to assess sleep.
PQ v RS [2019] EWHC 1643 (Ch): a case note
Authors: Campbell Emily 
Published: June 2021

Abstract
Many older settlements appear to restrict the class of children and issue who may benefit to those who are legitimate. Whether this is the full story and what trustees can do about it, given the impact of the issue on family harmony, was considered by Chief Master Marsh in the recent case of PQ v RS. The case is of particular interest on the point of the use of powers of appointment (rather than powers of advancement) to benefit non-objects.
Radial and axial water movement in adult trees recorded by stable isotope tracing
Authors: Treydte Kerstin , Lehmann Marco M , Wyczesany Tomasz , Pfautsch Sebastian 
Published: June 2021

AbstractThe capacity of trees to release water from storage compartments into the transpiration stream can mitigate damage to hydraulic functioning. However, the location of these ‘transient’ water sources and also the pathways of water movement other than vertical through tree stems still remain poorly understood. We conducted an experiment on two tree species in a common garden in eastern Australia that naturally grow in regions of high (Eucalyptus tereticornis, ‘Red Gum’) and low (Eucalyptus sideroxylon, ‘Ironbark’) annual precipitation rates. Deuterium-enriched water (1350% label strength) was directly introduced into the transpiration stream of three trees per species for four consecutive days. Subsequently, the trees were felled, woody tissue samples were collected from different heights and azimuthal positions of the stems, and stable isotope ratios were determined on the water extracted from all samples. The presence/absence of the tracer along the radial and vertical stem axes in combination with xylem hydraulic properties inferred from sapflow, leaf and stem water potentials, wood moisture contents and anatomical sapwood characteristics elucidated species-specific patterns of short-term stem water storage and movement. The distribution of water isotopes at natural abundance among woody tissues indicated systematic differences with highest values of sapwood water and lower values in inner bark and heartwood. Presence of tracer in water of the inner bark highlighted the importance of this tissue as capacitor. Although injected at the northern side of stems, tracer was also discovered at the southern side, providing empirical evidence for circumferential flow in sapwood, particularly of Ironbark. Greater vertical water transport in Red Gum compared with more radial and circumferential water transport in Ironbark were associated with species-specific sapwood anatomy. Our study highlights the value of combining information from stable isotope tracers and wood anatomy to investigate patterns of water transport and storage of tall trees in situ.
Development and Implementation of a Strong Mentoring Program to Increase Scholarly Productivity and Support Nurse Faculty Retention
Authors: Volkert Delene 
Published: June 2021

Abstract
This article discusses the development of a nurse faculty mentoring program at a public, four-year, comprehensive university in southeastern United States. The faculty mentoring program was designed to build the professional and scholarly development of both new faculty and their experienced faculty mentors. An additional goal was to encourage retention within the department.
The Proximal Placement of the Knee Joint in the 1-Stage Treatment of Infected Knee Revisions With Large Anterior Soft Tissue Defects
Authors: Maale Gerhard E. , Srinivasaraghavan Aniruth , Mohammadi Daniel K. , Kennard Nicole , Angobaldo Diego 
Published: June 2021

Introduction:
No good mechanisms are available for reconstruction of large anterior soft tissue defects associated with infected total knees [periprosthetic joint infections of the knee (PJI-K)]. Patellectomy is usually required due to involvement with adjacent large anterior soft tissue defects left after radical debridement, free flaps are required for closure. This type of flap necessitates the use of a drop lock brace in ambulation. Our question is whether the proximal placement of the knee joint with longer tibial segments can reduce the number of free flaps and reduce the need for a drop lock brace by reattaching the quadriceps directly to the hinged tibial component.

Methods:
We retrospectively analyzed 35 cases with a minimum 2-year follow-up. Of 1-stage total knee revisions for PJI-K with the proximal placement of the knee joint for large anterior soft tissue defects left after debridement.

Results:
The average knee joint displacement was 85 mm. Eleven recurred with infection and 4 required amputation. Eighteen had enough extensor power to walk with a cane or walker as opposed to requiring a drop lock brace. Fifteen patients did not need any free or local flaps, rather these patients only required adjacent soft tissue transfer during surgery.

Discussion:
This novel proximal placement of the knee joint in patients with PJI-K who have large anterior soft tissue defects lessens the need for free flaps. The proximal placement also allows for reconstruction of what is left of the quadriceps mechanism into the tibial component and usually provides enough extensor power to lock the hinge joint.
Caregiving for Aging Parents as a Source of Blessing
Authors: Conway Kimberly A. 
Published: June 2021

ABSTRACT:
This phenomenological secondary analysis of original research explored how adult caregivers of aging parents define the concept of being blessed. The disadvantages of caregiving dominate literature, but few research studies focus on positive aspects where caregivers emerge emotionally optimistic. Study participants expressed being blessed, such as being thankful, gaining a sense of peacefulness, reward, and meaningfulness. A conceptual definition of being blessed is proposed.
Acral Calcified Vascular Leiomyoma: Report of 3 Cases and Literature Review
Authors: Suárez-Peñaranda Jose M. , Pita da Veiga Gabriela , Pérez-Muñoz Noelia , Fernández-Figueras María-Teresa 
Published: June 2021

Abstract:
Angioleiomyomas are benign neoplasms, which usually present as solitary, slow-growing nodules on the skin of lower extremities, but acral location on the hands or feet is unusual. Yet, microscopically, they may show many histopathological variants, focal calcification is uncommon. Extensive calcification masquerading the real nature of the tumor has been rarely reported, the term acral calcified leiomyoma having been proposed for this entity. This change is more often in distal locations and has been interpreted as degenerative in nature, probably related to repetitive minor trauma. We report 3 examples of this unusual condition on the feet of 2 male and one female subjects (aged, 68, 69, and 80 years) and make a review of the 31 cases available in the literature. Two of our cases are associated with highly uncommon features, such as transepidermal calcium elimination and concomitant calcaneal spur.
Papillary Dermal Elastolysis Secondary to Combination Nivolumab and Cabiralizumab Therapy: Histiocytes and Dermal Mucin as Clues to the Diagnosis
Authors: Yin Lu , Criscito Maressa C. , Stokar Evan , Siolas Despina , Haimovic Adele , Lo Sicco Kristen , Brinster Nooshin K. 
Published: June 2021

Abstract:Papillary dermal elastolysis has been described in the setting of experimental combination nivolumab and cabiralizumab immunotherapy. We report a third patient with distinctive, generalized atrophic macules that developed after a morbilliform eruption during a clinical trial for treatment of metastatic pancreatic adenocarcinoma. Histopathological findings demonstrated diminished elastic fibers in the papillary dermis, associated with a histiocyte-rich infiltrate and increased dermal mucin, features that should clue the dermatopathologist to this condition.