bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health literacy among pregnant women in a lifestyle intervention trial: protocol for an explorative study on the role of health literacy in the perinatal health service setting
Authors: Nawabi Farah , Alayli Adrienne , Krebs Franziska , Lorenz Laura , Shukri Arim , Bau Anne-Madeleine , Stock Stephanie 
Published: July 2021

IntroductionPregnancy is a vulnerable period that affects long-term health of pregnant women and their unborn infants. Health literacy plays a crucial role in promoting healthy behaviour and thereby maintaining good health. This study explores the role of health literacy in the GeMuKi (acronym for ‘Gemeinsam Gesund: Vorsorge plus für Mutter und Kind’—Strengthening health promotion: enhanced check-up visits for mother and child) Project. It will assess the ability of the GeMuKi lifestyle intervention to positively affect health literacy levels through active participation in preventive counselling. The study also explores associations between health literacy, health outcomes, health service use and effectiveness of the intervention.Methods and analysisThe GeMuKi trial has a hybrid effectiveness–implementation design and is carried out in routine prenatal health service settings in Germany. Women (n=1860) are recruited by their gynaecologist during routine check-up visits before 12 weeks of gestation. Trained healthcare providers carry out counselling using motivational interviewing techniques to positively affect health literacy and lifestyle-related risk factors. Healthcare providers (gynaecologists and midwives) and women jointly agree on Specific, Measurable, Achievable Reasonable, Time-Bound goals. Women will be invited to fill in questionnaires at two time points (at recruitment and 37th−40th week of gestation) using an app. Health literacy is measured using the German version of the Health Literacy Survey-16 and the Brief Health Literacy Screener. Lifestyle is measured with questions on physical activity, nutrition, alcohol and drug use. Health outcomes of both mother and child, including gestational weight gain (GWG) will be documented at each routine visit. Health service use will be assessed using social health insurance claims data. Data analyses will be conducted using IBM SPSS Statistics, version 26.0. These include descriptive statistics, tests and regression models. A mediation model will be conducted to answer the question whether health behaviour mediates the association between health literacy and GWG.Ethics and disseminationThe study was approved by the University Hospital of Cologne Research Ethics Committee (ID: 18-163) and the State Chamber of Physicians in Baden-Wuerttemberg (ID: B-F-2018-100). Study results will be disseminated through (poster) presentations at conferences, publications in peer-reviewed journals and press releases.Trail registrationGerman Clinical Trials Register (DRKS00013173). Registered pre-results, 3rd of January 2019,https://www.drks.de
Depressive symptoms among people with HIV/AIDS in Northwest Ethiopia: comparative study
Authors: Mekonen Tesfa , Belete Habte , Fekadu Wubalem 
Published: July 2021

ObjectivesThe objective of this study was to compare depressive symptoms among people with HIV/AIDS and the general population sample. We also assessed the factors associated with depressive symptoms.DesignA comparative cross-sectional study was conducted.SettingsAntiretroviral therapy clinics in three primary healthcare facilities and semi-urban area in Northwest Ethiopia.ParticipantsA total of 1115 participants (558 people with HIV/AIDS and 557 comparison group) aged 18 years and above were recruited. A total of 1026 participants (530 people with HIV/AIDS and 496 comparison group) completed the interview. We excluded people with known HIV-positive status from the comparison group.Outcome measurePatient Health Questionnaire (PHQ-9) was used to assess depressive symptoms. The proportion of depressive symptoms was compared between samples of the general population and people with HIV/AIDS using χ2statistics. Multivariable logistic regression analysis was done to examine the associated factors.ResultsThe overall prevalence of depressive symptoms was 13.3% (11.2%–15.4%). The prevalence was significantly higher in people with HIV/AIDS compared with the community sample (16.6% vs 12.3%), p=0.001. The difference was also significant in the multivariable logistic regression (OR 1.7). For the overall sample, depressive symptoms were significantly associated with older age, being single, divorced/widowed marital status, and poor social support.ConclusionsDepressive symptoms were higher in people with HIV/AIDS compared with the general population. It is necessary to include mental healthcare and screening for depression in routine HIV/AIDS care.
The Magnetic Couples Study: protocol for a mixed methods prospective cohort study of HIV-serodifferent heterosexual couples’ perspectives and use of pre-exposure prophylaxis (PrEP)
Authors: McMahon James M. , Simmons Janie , Haberer Jessica E. , Mannheimer Sharon , Leblanc Natalie M. , Torres Leilani , Quiles Robert , Aedo Guillermo , Javier Anabel , Braksmajer Amy , Harriman Graham , Trabold Nicole , Pouget Enrique R. , Kurth Ann , Smith Martez D. R. , Brasch Judith , Podsiadly Eric J. , Anderson Peter L. 
Published: July 2021

IntroductionHIV transmission within serodifferent heterosexual couples plays a key role in sustaining the global HIV pandemic. In the USA, transmission within established mixed-status couples accounts for up to half of all new HIV infections among heterosexuals. Oral HIV pre-exposure prophylaxis (PrEP) is a highly effective prevention method, although underutilised among serodifferent couples. Moreover, there is a dearth of research on US HIV-serodifferent couples’ perspectives and use of PrEP, alone or in combination with other prevention methods. In this paper, we describe the study protocol for the Magnetic Couples Study, designed to fill critical knowledge gaps regarding HIV-serodifferent heterosexual couples’ perspectives, experiences and utilisation of PrEP.Methods and analysisThe Magnetic Couples Study is a mixed methods prospective cohort study designed to describe temporal patterns and identify determinants at multiple levels (individual, couple, HCF) of PrEP outcomes along the care continuum (PrEP awareness, linkage, uptake, retention and medication adherence) among HIV-serodifferent heterosexual couples residing in New York City. The study will also examine clinical management of PrEP, side effects and changes in sexual-related and substance use–related behaviour. A prospective cohort of 230 mixed-status couples already on oral PrEP was recruited, with quarterly assessments over 18 months; in addition, a cross-sectional sample of 150 mixed-status couples not currently on PrEP was recruited. In-depth semistructured qualitative interviews were conducted with a subsample of 25 couples. Actor-partner interdependence modelling using multilevel analysis will be employed for the analysis of longitudinal dyadic data. Framework analysis will be used to analyse qualitative data. A parallel convergent design will be used for mixed methods integration.Ethics and disseminationThe study was approved by the University of Rochester Institutional Review Board (RSRB00052766). Study findings will be disseminated to community members and providers and to researchers and policy makers.
Associations with sight-threatening diabetic macular oedema among Indigenous adults with type 2 diabetes attending an Indigenous primary care clinic in remote Australia: a Centre of Research Excellence in Diabetic Retinopathy and Telehealth Eye and Associated Medical Services Network study
Authors: Brazionis Laima , Keech Anthony , Ryan Christopher , Brown Alex , O'Neal David , Boffa John , Bursell Sven-Erik , Jenkins Alicia 
Published: July 2021

ObjectiveTo identify factors associated with sight-threatening diabetic macular oedema (STDM) in Indigenous Australians attending an Indigenous primary care clinic in remote Australia.Methods and analysisA cross-sectional study design of retinopathy screening data and routinely-collected clinical data among 236 adult Indigenous participants with type 2 diabetes (35.6% men) set in one Indigenous primary care clinic in remote Australia. The primary outcome variable was STDM assessed from retinal images.ResultsAge (median (range)) was 48 (21–86) years, and known diabetes duration (median (range)) was 8.0 (0–24) years. Prevalence of STDM was high (14.8%) and similar in men and women. STDM was associated with longer diabetes duration (11.7 vs 7.9 years, respectively; p<0.001) and markers of renal impairment: abnormal estimated Glomerular Filtration Rate (eGFR) (62.9 vs 38.3%, respectively; p=0.007), severe macroalbuminuria (>300 mg/mmol) (20.6 vs 5.7%, respectively; p=0.014) and chronic kidney disease (25.7 vs 12.2%, respectively; p=0.035). Some clinical factors differed by sex: anaemia was more prevalent in women. A higher proportion of men were smokers, prescribed statins and had increased albuminuria. Men had higher blood pressure, but lower glycated Haemoglobin A1c (HbA1c) levels and body mass index, than women.ConclusionSTDM prevalence was high and similar in men and women. Markers of renal impairment and longer diabetes duration were associated with STDM in this Indigenous primary care population. Embedded teleretinal screening, known diabetes duration-based risk stratification and targeted interventions may lower the prevalence of STDM in remote Indigenous primary care services.Trial registration numberAustralia and New Zealand Clinical Trials Register: ACTRN 12616000370404.
Procedural pain in patients with cancer: a Delphi expert management consensus
Authors: Villegas Estévez Francisco J , López Alarcón Maria Dolores , Beato Carmen , Sanz-Yagüe Almudena , Porta-Sales Josep , Morera López Rosa M 
Published: July 2021

ObjectivesDiagnosis, treatment and care of cancer often involve procedures that may be distressing and potentially painful for patients. The PROCEDIO Study aimed to generate expert-based recommendations on the management of moderate to severe procedural pain in inpatients and outpatients with cancer.MethodsUsing a two-round Delphi method, experts from pain and palliative care units, medical and radiation oncology and haematology departments expressed their agreement on 24 statements using a 9-point Likert scale, which were classified as appropriate (median 7–9), uncertain (4–6) or inappropriate (1–3). Consensus was achieved if at least two-thirds of the panel scored within the range containing the median.ResultsWith an overall agreement on the current definition of procedural pain, participants suggested a wider description based on evidence and their clinical experience. A strong consensus was achieved regarding the need for a comprehensive pre-procedural pain assessment and experts emphasised that healthcare professionals involved in procedural pain management should be adequately trained. Most panellists (98.2%) agreed that pharmacological treatment should be chosen considering the duration of the procedure. Transmucosal fentanyl (96.5%) and morphine (71.7%) were recommended as the most appropriate drugs. Oral and nasal transmucosal fentanyl were agreed as the most suitable for both outpatients and inpatients, while consensus was reached for intravenous and subcutaneous morphine for inpatients.ConclusionsThese results provide updated expert-based recommendations on the definition, prevention and treatment of moderate to severe procedural pain, which could inform specialists involved in pain management of patients with cancer.
Association between ibrutinib treatment and hypertension
Authors: Lee Dae Hyun , Hawk Fahad , Seok Kieun , Gliksman Matthew , Emole Josephine , Rhea Isaac B , Viganego Federico , Welter-Frost Allan , Armanious Merna , Shah Bijal , Chavez Juliio C , Pinilla-Ibarz Javier , Schabath Matthew B , Fradley Michael 
Published: July 2021

BackgroundIbrutinib is a tyrosine kinase inhibitor most commonly associated with atrial fibrillation. However, additional cardiotoxicities have been identified, including accelerated hypertension. The incidence and risk factors of new or worsening hypertension following ibrutinib treatment are not as well known.MethodsWe conducted a retrospective study of 144 patients diagnosed with B cell malignancies treated with ibrutinib (n=93) versus conventional chemoimmunotherapy (n=51) and evaluated their effects on blood pressure at 1, 2, 3 and 6 months after treatment initiation. Descriptive statistics were used to compare baseline characteristics for each treatment group. Fisher’s exact test was used to identify covariates significantly associated with the development of hypertension. Repeated measures analyses were conducted to analyse longitudinal blood pressure changes.ResultsBoth treatments had similar prevalence of baseline hypertension at 63.4% and 66.7%, respectively. There were no differences between treatments by age, sex and baseline cardiac comorbidities. Both systolic and diastolic blood pressure significantly increased over time with ibrutinib compared with baseline, whereas conventional chemoimmunotherapy was not associated with significant changes in blood pressure. Baseline hypertensive status did not affect the degree of blood pressure change over time. A significant increase in systolic blood pressure (defined as more than 10 mm Hg) was noted for ibrutinib (36.6%) compared with conventional chemoimmunotherapy (7.9%) at 1 month after treatment initiation. Despite being hypertensive at follow-up, 61.2% of patients who were treated with ibrutinib did not receive adequate blood pressure management (increase or addition of blood pressure medications). Within the ibrutinib group, of patients who developed more than 20 mm Hg increase in systolic blood pressure, only 52.9% had hypertension management changes.ConclusionsIbrutinib is associated with the development of hypertension and worsening of blood pressure. Cardiologists and oncologists must be aware of this cardiotoxicity to allow timely management of blood pressure elevations.
End-stage renal disease and metalworking fluid exposure
Authors: Shrestha Deepika , Picciotto Sally , LaValley Michael P , Liu Sa , Hammond S Katharine , Weiner Daniel E , Eisen Ellen A , Applebaum Katie M 
Published: July 2021

ObjectiveDespite increasing prevalence of end-stage renal disease (ESRD), little attention has been directed to how occupational exposures may contribute to risk. Our objective was to investigate the relationship between metalworking fluids (MWF) and ESRD in a cohort of 36 703 male autoworkers.MethodsWe accounted for competing risk of death, using the subdistribution hazard approach to estimate subhazard ratios (sHRs) and 95% CIs in models with cubic splines for cumulative exposure to MWF (straight, soluble or synthetic).ResultsBased on 501 ESRD cases and 13 434 deaths, we did not observe an association between MWF and ESRD overall. We observed modest associations between MWF and ESRD classification of glomerulonephritis and diabetic nephropathy. For glomerulonephritis, the 60th percentile of straight MWF was associated with an 18% increased subhazard (sHR=1.18, 95% CI: 0.99 to 1.41). For diabetic nephropathy, the subhazard increased 28% at the 60th percentile of soluble MWF (sHR=1.28, 95% CI: 1.00 to 1.64). Differences by race suggest that black males may have higher disease rates following MWF exposure.ConclusionsExposure to straight and soluble MWF may be related to ESRD classification, though this relationship should be further examined.
Holographic p-wave superconductivity from higher derivative theory
Authors: Liu Yan , Fu Guoyang , Li Hai-Li , Wu Jian-Pin , Zhang Xin 
Published: July 2021

AbstractWe construct a holographic SU(2) p-wave superconductor model with Weyl corrections. The high derivative (HD) terms do not seem to spoil the generation of the p-wave superconducting phase. We mainly study the properties of AC conductivity, which is absent in holographic SU(2) p-wave superconductor with Weyl corrections. The conductivities in superconducting phase exhibit obvious anisotropic behaviors. Along y direction, the conductivity $$\sigma _{yy}$$

σ

yy

is similar to that of holographic s-wave superconductor. The superconducting energy gap exhibits a wide extension. For the conductivity $$\sigma _{xx}$$

σ

xx

along x direction, the behaviors of the real part in the normal state are closely similar to that of $$\sigma _{yy}$$

σ

yy

. However, the anisotropy of the conductivity obviously shows up in the superconducting phase. A Drude-like peak at low frequency emerges in $$Re\sigma _{xx}$$

R
e

σ

xx

once the system enters into the superconducting phase, regardless of the behaviors in normal state.
Quark star matter at finite temperature in a quasiparticle model
Authors: Chu Peng-Cheng , Jiang Yao-Yao , Liu He , Zhang Zhen , Zhang Xiao-Min , Li Xiao-Hua 
Published: July 2021

AbstractWe study the thermodynamic properties of asymmetric quark matter, large mass quark stars (QSs), and proto-quark stars (PQSs) within the quasiparticle model. Considering the effects of temperature within quasiparticle model can significantly influence the EOS and the entropy of strange quark matter (SQM), quark fractions in SQM, as well as the tidal deformability and the maximum mass of PQSs along the star evolution line. Our results indicate that the recent discovered heavy compact stars PSR J0348+0432, MSR J0740+6620, PSR J2215+5135, and especially the GW190814’s secondary component $$m_2$$

m
2

can be well described as QSs within the quasiparticle model. The tidal deformability for the QSs describing the heavy compact stars is extremely large, which can not well describe GW170817 as QSs, and the effects of the temperature in the heating process along the star evolution will further increase the tidal deformability and the maximum mass of PQSs.
Self-rotation of emitting galaxies without dark matter
Authors: Bulyzhenkov Igor É 
Published: July 2021

AbstractTemporal derivatives of the attracting mass in Newton’s law of distant interactions can balance the centripetal and centrifugal accelerations for the rotating periphery of a spiral galaxy. Thermal losses of the mass-energy integral inside the circle of rotation are the cause of the mega-vortex organization of the emitting galaxy. To reject dark matter in cosmic distributions, a conceptual modification of the Euler/Navier–Stokes hydrodynamics is required using adaptive tensor responses with metric waves but not gravimagnetic corrections from General Relativity.
Implementing an X-ray tomography method for fusion devices
Authors: Jardin A. , Bielecki J. , Mazon D. , Peysson Y. , Król K. , Dworak D. , Scholz M. 
Published: July 2021

AbstractIn fusion devices, the X-ray plasma emissivity contains essential information on the magnetohydrodynamic activity, the magnetic equilibrium and on the transport of impurities, in particular for tokamaks in the soft X-ray (SXR) energy range of 0.1–20 keV. In this context, tomography diagnostics are a key method to estimate the local plasma emissivity from a given set of line-integrated measurements. Unfortunately, the reconstruction problem is mathematically ill-posed, due to very sparse and noisy measurements, requiring an adequate regularization procedure. The goal of this paper is to introduce, with a didactic approach, some methodology and tools to develop an X-ray tomography algorithm. Based on a simple 1D tomography problem, the Tikhonov regularization is described in detail with a study of the optimal reconstruction parameters, such as the choice of the emissivity spatial resolution and the regularization parameter. A methodology is proposed to perform an in situ sensitivity and position cross-calibration of the detectors with an iterative procedure, by using the information redundancy and data variability in a given set of reconstructed profiles. Finally, the basic steps to build a synthetic tomography diagnostics in a more realistic tokamak environment are introduced, together with some tools to assess the capabilities of the 2D tomography algorithm.
A study on the preparation and quality standard of Saifula granules
Authors: Aisha Maimaiti , Wahafu Atikanmu , Kuerban Yilifanjiang , Aierken Akenmujiang , Saimaiti Refuhati , Kadi Maimaitiaili , Talifu Ainiwaer 
Published: July 2021

Objective: To establish the decocting and formulation technology of Saifula granules, and establish a reliable TLC identification quality control standard. Methods: Orthogonal test was used to optimize the water extraction process and TLC was used for qualitative identification. Results: To optimize the process parameters of SFL granules, first, the content of total flavonoids and the total extraction rate were taken as the indexes. Through single factor and orthogonal test, the optimal extraction process was determined as follows: extraction time 1 h, solvent multiple 1:10, extract three times. After the process parameters were determined, in order to further explain the chemical composition of SFL extract, 15 compounds in SFL extract were identified by UHPLC-Q-Orbitrap-MS, 13 batches of SFL extracts were prepared, and their fingerprints were analyzed. The results showed that there were 28 common characteristic peaks in the 13 batches of SFL extracts. The similarity evaluation results of fingerprints showed that the similarities of 13 batches of SFL extracts were greater than 0.9. An HPLC-DAD method for the simultaneous determination of gallic acid, corilagin, and ellagic acid was established. The method has good repeatability, stability, and accurate results. Conclusion: The standard can comprehensively reflect the material basis of SFL granules, and the above methods are accurate, easy to operate, stable and feasible, and provide scientific basis and basis for the development, promotion, and clinical application of SFL granules.