bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of endometriosis on female fertility and the management options for endometriosis-related infertility in reproductive age women: a scoping review with recent evidences
Authors: Vatsa Richa , Sethi Ankita 
Published: October 2021

Abstract
Background
Endometriosis is a chronic inflammatory condition with varied presentation, which ultimately leads to chronic pelvic pain and infertility. It is a psychological and economic burden to the women and their families.

Main body of abstract
The literature search was performed on the following databases: MEDLINE, Google Scholar, Scopus, EMBASE, Global health, the COCHRANE library, and Web of Science. We searched the entirety of those databases for studies published until July 2020 and in English language. The literature search was conducted using the combination of the Medical Subject heading (MeSH) and any relevant keywords for “endometriosis related infertility and management” in different orders. The modalities of treatment of infertility in these patients are heterogeneous and inconclusive among the infertility experts. In this article, we tried to review the literature and look for the evidences for management of infertility caused by endometriosis. In stage I/II endometriosis, laparoscopic ablation leads to improvement in LBR. In stage III/IV, operative laparoscopy better than expectant management, to increase spontaneous pregnancy rates. Repeat surgery in stage III/IV rarely increases fecundability as it will decrease the ovarian reserve, and IVF will be better in these patients. The beneficial impact of GnRH agonist down-regulation in ART is undisputed. Dienogest is an upcoming and new alternative to GnRH agonist, with a better side effect profile. IVF + ICSI may be beneficial as compared to IVF alone. Younger patients planned for surgery due to pain or any other reason should be given the option of fertility preservation.

Short conclusion
In women with endometriosis-related infertility, clinician should individualize management, with patient-centred, multi-modal, and interdisciplinary integrated approach.
Unexplained back pain and sciatica: the added value of upright dynamic MRI of the lumbar spine in cases of clinical/radiological mismatch
Authors: Ibrahim Heba , Diab Khaled 
Published: October 2021

Abstract
Background
Degenerative disease of the lumbar spine is one of the most prevalent pathologies worldwide, and MRI is the gold standard imaging modality that helps to assess soft tissue and bony abnormalities and elicit causes of neural compression. It is not uncommon in the daily practice to have patients presenting with neurological symptoms during standing or walking while MRI fails to detect lesion that explains their clinical picture. The aim of this study was to detect changes that appear on dynamic weight-bearing MRI of the lumbar spine that was hidden on conventional supine MRI and to correlate them with the clinical situation.

Methodology
Ninety patients with back pain were enrolled in the study, they did conventional and dynamic MRI of the lumbar spine. We compared findings in both modalities as regard alignment, ligamentum flavum buckling, foraminal narrowing and neural compression.

Results
Dynamic MRI showed neural compression in 87% of patients in comparison to supine MRI, ligamentum flavum buckling was reported in 80%, neural foraminal narrowing was seen in 24%, exaggeration of the lumbar lordoisis in 10% and exaggeration of the already existing disc protrusion was documented in 60% of the included patients.

Conclusions
Upright dynamic MRI has added to supine MRI in problem solving cases with clinical radiological mismatch. The results indicated changes in the spine alignment, neural compression and spinal canal stenosis. Since the examination is non-invasive, it could be used in the preoperative planning of patients with degenerative lumbar spine disease.
Large Eddy simulation of the fluctuating wind environment at a bridge site in the mountainous area
Authors: Xing Longfei , Zhang Mingjin , Li Yongle , Zhang Zhijie , Yin Dianguo 
Published: October 2021

AbstractTo have a comprehensive understanding of the complex wind environment at a bridge site in the mountainous area, a numerical simulation study of the wind environment under the mean and the fluctuating wind flow conditions was carried out and the results were compared. First, according to the weighted amplitude wave superposition (WAWS) method, the fluctuating wind speed time history was compiled by UDF. And the wind speed time history was added to the inlet boundary of a numerical empty wind tunnel to verify the feasibility of the simulation method of the fluctuating wind. Then, with a bridge in the mountainous area in Yunnan as the engineering background, a numerical simulation study of the wind environment of the bridge site area under the mean wind flow and the fluctuating wind flow was carried out by using FLUENT. The study indicates that Large Eddy Simulation (LES) method more accurate than Reynold average method with a sufficient number of grids and a short enough time step. The average wind characteristics of the bridge site under the mean wind and the fluctuating wind are not much different. The fluctuating wind characteristics at the bridge site are mainly affected by the terrain and the pulsating component of the wind flow. There are different terrain pulsation effects at the bridge site under different incoming flow directions.
Molecular Subgroup Is the Strongest Predictor of Medulloblastoma Outcome in a Resource-Limited Country
Authors: Amayiri Nisreen , Swaidan Maisa , Ibrahimi Ahmed , Hirmas Nader , Musharbash Awni , Bouffet Eric , Al-Hussaini Maysa , Ramaswamy Vijay 
Published: October 2021

PURPOSE Medulloblastoma is composed of four clinically and prognostically distinct molecular subgroups (WNT, SHH, group 3, and group 4). However, the clinical implications of these subgroups in the context of the unique challenges of low- to middle-income countries are rarely reported. METHODS We assembled an institutional cohort of children (3-18 years) diagnosed with medulloblastoma and treated in Jordan between 2003 and 2016. Tumors were subgrouped by NanoString and correlated with clinical and radiologic characteristics. RESULTS Eighty-eight patients were identified (63% male); median age was 6.9 years (interquartile range 4.8-9.2) and median symptom duration was 6 weeks (interquartile range 4-11). Radiotherapy was implemented as standard-risk in 41 patients (47%) and high-risk in 47 patients (53%). Subgrouping revealed 17 WNT (19%), 22 SHH (25%), 21 group 3 (24%), and 28 group 4 tumors (32%). Median time between craniotomy and radiotherapy was 45 days (17-155); 44% of them > 49 days. Median duration of radiotherapy was 44 days (36-74). Seventy-two patients (82%) received chemotherapy afterward. With a median follow-up of 4.6 years (0.2-14.9), 5-year progression-free survival (PFS) and overall survival were 73.5% and 69.4%, respectively, with no statistically significant survival difference between standard-risk and high-risk patients. Metastasis was significant for overall survival ( P = .011). Patients with SHH and group 4 tumors had very good PFS (83.4% and 87.0%, respectively) and those with group 3 tumors had dismal outcomes (PFS 44.9%), whereas WNT tumors had less-than expected PFS (70.5%). PFS was statistically significant in patients with nonmetastatic tumors receiving radiotherapy ≤ 49 days ( P = .011), particularly group 3 tumors. CONCLUSION Patients with SHH and group 4 medulloblastoma had excellent survival comparable with high-income countries. Compliance with treatment protocols and avoiding radiotherapy delays are important in achieving adequate survival in low- to middle-income country settings. Subgroup-driven treatment protocols should be considered in countries with limited resources.
Efficacy of mesenchymal stromal cells in preclinical models of necrotizing enterocolitis: a systematic review protocol
Authors: Maltais-Bilodeau Camille , Henckel Ewa , D. Cobey Kelly , Ahmadzai Nadera , Skidmore Becky , Ferretti Emanuela , Thébaud Bernard 
Published: October 2021

Introduction: Necrotizing enterocolitis is an acute inflammatory disease of the intestine that can lead to necrosis and bowel perforation. It is a severe complication of preterm birth. It’s mortality rate is up to 50% and survival after necrotizing enterocolitis leads to long-term complications. The current treatment is supportive and includes bowel rest and decompression and antibiotics. Thus, new treatments are necessary to reduce mortality and morbidity. Mesenchymal stromal cells are known to have anti-inflammatory properties and might be a promising option for treatment. Here we present a protocol for a systematic review with the aim to explore the efficacy of cell therapies with mesenchymal stromal cells in animal models of necrotizing enterocolitis. The primary outcome is histological signs of necrotizing enterocolitis. Additional outcomes include survival, bowel perforation, gut permeability, gut motility, levels of inflammatory markers, cytokine levels and adverse events. Methods: We will conduct a systematic search of MEDLINE, Embase, and Web of Science databases. The retrieved records will be screened individually by two investigators. We will include all preclinical in vivo animal models of experimentally induced necrotizing enterocolitis that evaluate the efficacy of mesenchymal stromal cells or other cell therapy treatments. Outcome data will be extracted from each article and risk of bias assessment performed. Funnel plots and SYRCLE’s risk of bias tool for animal studies will be used. Data will be reported as ratios, divided in predefined subgroups where relevant. Conclusions: This systematic review aims to examine the efficacy of mesenchymal stromal cells in preclinical models of necrotizing enterocolitis and whether there is sufficient evidence to support a clinical trial of efficacy and safety of the treatment with mesenchymal stromal cells in infants with necrotizing enterocolitis.
Mitral regurgitation quantification by cardiac magnetic resonance imaging (MRI) remains reproducible between software solutions
Authors: Grafton-Clarke Ciaran , Thornton George , Fidock Benjamin , Archer Gareth , Hose Rod , van der Geest Rob J. , Zhong Liang , Swift Andrew J. , Wild James M. , De Gárate Estefania , Bucciarelli-Ducci Chiara , Plein Sven , Treibel Thomas A. , Flather Marcus , Vassiliou Vassilios S. , Garg Pankaj 
Published: October 2021

Background: The reproducibility of mitral regurgitation (MR) quantification by cardiovascular magnetic resonance (CMR) imaging using different software solutions remains unclear. This research aimed to investigate the reproducibility of MR quantification between two software solutions: MASS (version 2019 EXP, LUMC, Netherlands) and CAAS (version 5.2, Pie Medical Imaging). Methods: CMR data of 35 patients with MR (12 primary MR, 13 mitral valve repair/replacement, and ten secondary MR) was used. Four methods of MR volume quantification were studied, including two 4D-flow CMR methods (MRMVAV and MRJet) and two non-4D-flow techniques (MRStandard and MRLVRV). We conducted within-software and inter-software correlation and agreement analyses. Results: All methods demonstrated significant correlation between the two software solutions: MRStandard (r=0.92, p<0.001), MRLVRV (r=0.95, p<0.001), MRJet (r=0.86, p<0.001), and MRMVAV (r=0.91, p<0.001). Between CAAS and MASS, MRJet and MRMVAV, compared to each of the four methods, were the only methods not to be associated with significant bias. Conclusions: We conclude that 4D-flow CMR methods demonstrate equivalent reproducibility to non-4D-flow methods but greater levels of agreement between software solutions.
Electrical crosstalk analysis in a pinned photodiode CMOS image sensor array
Authors: Khabir Mehdi , Alaibakhsh Hamzeh , Karami Mohammad Azim 
Published: October 2021

In this paper, a complete investigation and 2D simulation of electrical crosstalk in a setup with three neighboring pinned photodiode complementary metal-oxide-semiconductor (CMOS) image sensor pixels are performed. Electrical crosstalk characterization as a function of pixel size and epitaxial layer doping concentration is presented. The simulation results in constant epitaxial layer doping concentration show that the ratio of external quantum efficiency to electrical crosstalk is linear with respect to pixel size. In the pixel size of 3.7 µm, the turning point in the correlation trend between external quantum efficiency and electrical crosstalk from a small pixel size to a large one occurs. In addition, the simulation results show the optimal values of external quantum efficiency and electrical crosstalk occurs at

1

×

1

0

14

(

c

m

−
3

) in a constant pixel size. Moreover, the ratio of external quantum efficiency to the electrical crosstalk decreases linearly with respect to the epitaxial layer doping considering above

1

×

1

0

14

(

c

m

−
3

).
Binarization for low-quality ESPI fringe patterns based on preprocessing and clustering
Authors: Chen Lei , Tang Chen , Xu Min , Lei Zhenkun 
Published: October 2021

Massive inherent speckle noise and extremely low contrast make it difficult to binarize electronic speckle pattern interferometry (ESPI) fringe patterns. In this paper, we present a binarization based on preprocessing and fuzzy C-means (FCM) clustering for low-quality ESPI fringe patterns. First, we use the multiscale retinex (MSR) algorithm to enhance the original fringe pattern to improve the contrast between the bright and dark fringes. Then, the local entropy of the enhanced fringe pattern is calculated and the second-order oriented partial differential equation algorithm is introduced to filter the local entropy map. Finally, the FCM is applied to cluster the local entropy filtering map, and the pixels of the fringe pattern are classified into two categories: bright fringes and dark fringes. To verify the reliability and universality of the proposed method, we provide a qualitative evaluation of six experimental ESPI subtraction fringe patterns and two computer-simulated ESPI addition fringe patterns. Experimental results exhibit that the proposed method can provide good binarization performances.
Refractive index sensor for sensing high refractive index bioliquids at the THz frequency
Authors: Kumar Amit , Verma Pankaj , Jindal Poonam 
Published: October 2021

In this paper, a highly sensitive and low loss refractive index (RI) biosensor for high RI bio-analytes detection, such as for cholesterol, nicotine, and bacillus bacteria, is proposed. A novel, to the best of our knowledge, decagonal structure with porous core photonic crystal fiber (PC-PCF) is introduced. The porous core consists of a rectangular sensing hole. The analytes to be sensed are considered in liquid form and infiltrated into the sensing holes, which makes the sensing process simpler and more straightforward. Cladding of the PC-PCF consists of multilayer circular air holes arranged in a decagonal pattern. For durability and stability of the sensor, TOPAS is used as the fiber material. A perfectly matched layer is used for boundary conditions. The correlation among optical power, material, and structural properties is analyzed by the finite element method. The sensing performance of the designed sensor is observed at THz frequency (1.4–3.8 THz). The results under high RI of the analytes (1.52–1.55) are as follows: maximum sensitivity of 98.31% for

x

polarization and 98.26% for

y

polarization, very low confinement loss of

1.5

×

10

−
14

d
B

/

m

, narrow effective mode area of

1.92

×

10

−
7

m

2

, minimum effective material loss of

0.000164

c
m

−
1

, and very low waveguide dispersion of

0.002
±
0.05

ps/THz/cm. In addition, the effect of variation of structural parameters on sensor performance is also analyzed. The proposed PC-PCF-based biosensor can be very useful for sensing higher RI biochemical analytes.
Integrated reference cavity with dual-mode optical thermometry for frequency correction
Authors: Zhao Qiancheng , Harrington Mark W. , Isichenko Andrei , Liu Kaikai , Behunin Ryan O. , Papp Scott B. , Rakich Peter T. , Hoyt Chad W. , Fertig Chad , Blumenthal Daniel J. 
Published: October 2021

Photonic integrated resonators have advantages over traditional benchtop cavities in terms of size, weight, and cost with the potential to enable applications that require spectrally pure light. However, integrated resonators suffer from temperature-dependent frequency variations and are sensitive to external environmental perturbations, which hinders their usage in precision frequency applications. One solution is to use interrogation of the cavity temperature through dual-mode optical thermometry (DMOT) by measuring the shift of the resonance frequency difference between two polarization or optical frequency modes. Yet this approach has only been demonstrated in bulk-optic whispering gallery mode and fiber resonators. In this paper, we implement dual-mode optical thermometry in an ultra-high

Q

integrated silicon nitride resonator. A dual-mode resonance frequency difference temperature sensitivity of

188

±

15

M
H
z

/

K

is measured. We demonstrate feedforward DMOT frequency correction that, under an applied external temperature ramp, is able to reduce the optical frequency change to 0.31 kHz/s as compared to an uncorrected 10.03 kHz/s, a factor of

30

×

reduction. These results show promise for on-chip frequency correction solutions for quantum, metrology, atomic, and coherent optical communications applications.
Frequency-multiplexed entanglement for continuous-variable quantum key distribution
Authors: Kovalenko Olena , Ra Young-Sik , Cai Yin , Usenko Vladyslav C. , Fabre Claude , Treps Nicolas , Filip Radim 
Published: October 2021

Quantum key distribution with continuous variables already uses advantageous high-speed single-mode homodyne detection with low electronic noise at room temperature. Together with continuous-variable information encoding to nonclassical states, the distance for secure key transmission through lossy channels can approach 300 km in current optical fibers. Such protocols tolerate higher channel noise and also limited data processing efficiency compared to coherent-state protocols. The secret key rate can be further increased by increasing the system clock rates, and, further, by a suitable frequency-mode-multiplexing of optical transmission channels. However, the multiplexed modes couple together in the source or any other part of the protocol. Therefore, multiplexed communication will experience cross talk and the gain can be minuscule. Advantageously, homodyne detectors allow solving this cross-talk problem by proper data processing. It is a potential advantage over protocols with single-photon detectors, which do not enable similar data processing techniques. We demonstrate the positive outcome of this methodology on the experimentally characterized frequency-multiplexed entangled source of femtosecond optical pulses with natural cross talk between eight entangled pairs of modes. As the main result, we predict the almost 15-fold higher secret key rate. This experimental test and analysis of frequency-multiplexed entanglement source open the way for the field implementation of high-capacity quantum key distribution with continuous variables.
Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis
Authors: Jin Qiuchen , Teng Fangjun , Cheng Zhigang 
Published: October 2021

BackgroundPro-inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor α (TNFα) play important roles in host immune response and bone metabolism during dental implant osseointegration. Whether the functional polymorphisms in IL-1α, IL-1β and TNFα were associated with peri-implant disease was unclear, and we performed the present meta-analysis for this purpose.MethodsEligible studies investigating IL-1α C-889T, IL-1β C+3954T and C-511T, TNFα G-308A, composite genotype of IL-1α C-889T and IL-1β C+3954T for association with peri-implant disease, including peri-implantitis (PI), marginal bone loss (MBL) and implant failure/loss (IF/IL), were searched on several literature databases prior to April 30, 2021. Odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated for each polymorphism in different genetic models and for composite genotype comparing carriers to non-carriers.ResultsTwenty-seven studies (1324 cases with peri-implant disease and 1808 controls with healthy implants) were included. There was significant correlation between IL-1α C-889T and peri-implant disease in all genetic models. IL-1β C+3954T was associated with peri-implant disease risk in allelic (OR = 1.66, 95%CI 1.17–2.35, p = 0.004) and dominant model (OR = 1.74, 95%CI 1.19–2.53, p = 0.004), and in subgroups of Asians, Caucasians, non-smokers, IF/IL and PI. TT genotype of IL-1β C-511T increased the risk of peri-implant disease (OR = 1.68, 95%CI 1.15–2.43, p = 0.007) and MBL (OR = 4.33, 95%CI 1.72–10.9, p = 0.002) compared to CC+CT genotypes. We did not observed a significant association between TNFα G-308A and peri-implant diseases in overall or subgroups analysis. Carriers of positive composite genotype of IL-1α C-889T and IL-1β C+3954T had 1.95-fold (95%CI 1.35–2.80, p<0.001) risk of peri-implant disease and 1.76-fold (95%CI 1.05–2.95, p = 0.032) risk of IF/IL than non-carriers.ConclusionFunctional polymorphisms of IL-1α (C-889T), IL-1β (C+3954T, C-511T) and composite genotype of IL-1 can be used as predictive markers for peri-implant disease, whereas TNFα G-308A polymorphism was not associated with peri-implant disease.
The Effect of Workplace Spirituality, Perceived Organizational Support, and Innovative Work Behavior: The Mediating Role of Psychological Well-Being
Authors: Masyhuri Masyhuri , Pardiman Pardiman , Siswanto Siswanto 
Published: October 2021

This research investigating the innovative work behavior of teachers and school staffÂ during the Covid-19 pandemic is still rarely studied, so it has contributed toÂ improving the behavior of teachers and school staff in Indonesia during the Covid-19Â pandemic. The purpose of this study was to analyze and examine the direct influenceÂ of workplace spirituality and perceived organizational support on the innovative workÂ behavior of teachers and school staff. Besides, exploring the mediating role ofÂ psychological health variables. The research sample was 379 teachers and school staffÂ that is analyzed using SEM-PLS. The results showed that workplace spirituality andÂ perceived organizational support had a direct effect on innovative work behavior.Psychological well-being also affects innovative work behavior. This study also shows that psychological well-being has a role in mediating the influence between work-place spirituality and perceived organizational support for innovative work behavior. ThisÂ study indicates that workplace spirituality and workplace spirituality can be directlyÂ and indirectly through psychological well-being to increase the innovative behaviorÂ of teachers and school staff in learning activities at school.