bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geochronology of the mega-landslides of the last million years in Tenerife. Part II New contributions to knowledge about the landslides
Authors: Ferrer Gijón Mercedes , González de Vallejo Luis Ignacio , García López-Davalillo Juan Carlos 
Published: September 2021

The review on the ages available in the bibliography (1972-2019) related to the mega-landslides of the island of Tenerife in the last million years, and the new Ar/Ar ages we have obtained have allowed us to propose the following ages for the landslides of: Icod: ~170 ka; La Orotava: ~560, ~530 y ~500(?) ka; Güímar: ~830 ka; and Micheque: 810-830 ka (Ferrer et al., 2020-this volume). The relationship between the ages of the landslides and the geological and geomorphological evidence that support the flank instability failure processes, based on field observations in outcrops and underground data -from thegalleries excavated through the filling of the landslide valley- are presented. The hypothesis of several overlapping flank landslides, with time intervals of at least several tens of thousands of years is proposed, ruling out the occurrence of single processes of massive and instantaneous failure of the insular flank; thus, in the case of the La Orotava valley, an age of around 530 ka is confirmed for a large landslide, as well as the occurrence of other landslides around 560 ka and 500 ka. The relationship and causality between the Icod landslide, the last one that occurred in Tenerife, and the great explosive eruption at the end of the Cañadas cycle, and not the opposite as some authors have suggested, has also been analyzed, concluding that the explosion was a consequence of the landslide, ~170 ka ago. New data and evidence for the Micheque landslide are shown, indicating a Pliocene age for the deep substrate of the La Orotava and Micheque landslides.
Stem Cells as a Potential Therapeutic Option for Treating Neurodegenerative Diseases
Authors: Aishwarya L , Arun Dharmarajan , Kannan Suresh 
Published: September 2021

:
In future, neurodegenerative diseases will take over cancer's place and become the major
cause of death in the world, especially in developed countries. Advancements in the medical
field and its facilities have led to an increase in the old age population, and thus contributing to the
increase in number of people suffering from neurodegenerative diseases. Economically it is a great
burden to society and the affected family. No current treatment aims to replace, protect, and regenerate
lost neurons; instead, it alleviates the symptoms, extends the life span by a few months and
creates severe side effects. Moreover, people who are affected are physically dependent for performing
their basic activities, which makes their life miserable. There is an urgent need for therapy
that could be able to overcome the deficits of conventional therapy for neurodegenerative diseases.
Stem cells, the unspecialized cells with the properties of self-renewing and potency to differentiate
into various cells types, can become a potent therapeutic option for neurodegenerative diseases.
Stem cells have been widely used in clinical trials to evaluate their potential in curing different
types of ailments. In this review, we discuss the various types of stem cells and their potential use
in the treatment of neurodegenerative diseases-plural based on published preclinical and clinical
studies.
3D Printed Composite Scaffolds in Bone Tissue Engineering: A Systematic Review
Authors: Rad Maryam Rezai , Khojasteh Arash , Mohaghegh Sadra , Hosseini Seyedeh Fatemeh 
Published: September 2021

Objective:
This study aimed to analyze the effect of fabrication factors on both biological
and physico-chemical features of 3-dimensional (3D) printed composite scaffolds.

Method:
Electronic search was done according to the PRISMA guideline in PubMed and Scopus
databases limited to English articles published until May 2021. Studies in which composite scaffolds
were fabricated through computer-aided design and computer-aided manufacturing (CADCAM)-
based methods were included. Articles regarding the features of the scaffolds fabricated
through indirect techniques were excluded.

Results:
Full text of 121 studies were reviewed, and 69 met the inclusion criteria. According to
analyzed studies, PCL and HA were the most commonly used polymer and ceramic, respectively.
Besides, the solvent-based technique was the most commonly used composition technique,
which enabled preparing blends with high concentrations of ceramic materials. The most common
fabrication method used in the included studies was fused deposition modeling (FDM). The
addition of bio-ceramics enhanced the mechanical features and the biological behaviors of the
printed scaffolds in a ratio-dependent manner. However, studies that analyzed the effect of ceramic
weight ratio showed that scaffolds with the highest ceramic content did not necessarily
possess the optimal biological and non-biological features.

Conclusion:
The biological and physico-chemical behaviors of the scaffold can be affected by
pre-printing factors, including utilized materials, composition techniques, and fabrication methods.
Fabricating scaffolds with high mineral content as of the natural bone may not provide the
optimal condition for bone formation. Therefore, it is recommended that future studies compare
the efficiency of different kinds of biomaterials rather than different weight ratios of one type.
Cross-sectional Relationships Between Alternate Healthy Eating Index (AHEI) with General and Abdominal Obesity and Blood Pressure in Iranian Hospital Employees
Authors: Mirashrafi Shahrzad , Kafeshani Marzieh , Hassanzadeh Akbar , Entezari Mohammad H. 
Published: September 2021

Background and Aims:
Due to the increasing prevalence of obesity and related disorders,
there is an urgent need to examine the relationship between diet quality and public health.
The Alternative Healthy Eating Index (AHEI) is one of the indices that is used to assess diet quality.
Therefore, we investigated the relationship between AHEI and anthropometric measurements
and blood pressure.

Methods:
In this cross-sectional study, 127 male and female hospital employees were examined.
The AHEI was calculated by a 168 items Food Frequency Questionnaire. Body weight, height,
Body Mass Index (BMI), Waist Circumference (WC), Waist-to-Hip Ratio (WHR) and blood pressure
were measured by skilled nutritionists. Physical activity level was also obtained by International
Physical Activity Questionnaire (IPAQ).

Results :
The mean total AHEI score in participants was reported as 47.1±6.9 (min=31.9,
max=60.3). The mean differences of total AHEI score across the obese/non-obese employees were
not statistically significant (P>0.05). Furthermore, there was no significant correlation between total
AHEI score and BMI (r=0.019), WC (r=0.022), WHR (r=-0.102), systolic (r=-0.133) and diastolic
blood pressure (r=-0.040) (P>0.05). The score of nuts and soybeans was inversely related to
the WHR (P=0.008) and systolic blood pressure (P=0.030). Cereal fiber score had a negative relationship
with BMI (P=0.02), WC (P=0.03), WHR (P=0.004) and systolic (P<0.001) and diastolic
blood pressure (P=0.012).

Conclusion:
Consumption of nuts and soybeans -one serving per day- can be associated with
WHR and systolic blood pressure reduction. More studies with a larger scale are needed to examine
diet quality.
Recent Patents on Detection of Bearing Temperature
Authors: Zhao Yanling , Zhang Jiashuo 
Published: September 2021

Background:
One of the critical factors affecting the life of bearings is the bearing temperature
during operation, so the temperature is an important parameter to detect the running state of
the bearing. The abnormal increase in bearing temperature can reflect problems such as bearing
damage, lack of lubricating oil, and installation errors. With the continuous improvement of rotating
machinery equipment operating speed, load level and equipment processing accuracy requirements,
there is an urgent need to detect and analyze the temperature rise of bearings.

Objective:
By analyzing recent representative patents for bearing temperature detection, we summarize
the characteristics and problems of current bearing temperature detection devices and provide a
reference for the future development of bearing temperature detection devices

Methods:
This article traces the recent representative patents related to bearing temperature detection
method and device structure.

Results:
Through the investigation of a large number of patents of bearing temperature detection devices,
the main existing problems in the system and structure of bearing temperature detection are concluded
and analyzed, and the development of bearing temperature detection is discussed in the future.

Conclusion:
The bearing temperature measuring device is significant for analyzing bearing heating
and detecting the running state of the bearing. The current research results need further development
and improvement. With the development of automated detection technology, bearing temperature
measurement is also evolving towards intelligence and dynamics. It is foreseeable that more related
patents on bearing temperature detection will be invented.
A Review of Phenobarbital for Alcohol Withdrawal Syndrome
Authors: Saadatmand Heva J. , Ho Pochu 
Published: September 2021

Background:
Alcohol use disorder represents a serious health problem worldwide which is
increasing in pervasiveness. Alcohol withdrawal syndrome is a common clinical problem encountered
in emergency departments and inpatient settings, including intensive care units. While benzodiazepines
are the most widely used class of medication for the treatment of alcohol withdrawal, in recent
years, there is renewed interest in using phenobarbital, a barbiturate, in the treatment of refractory alcohol
withdrawal.

Objective:
This review provides an overview of phenobarbital in the treatment of alcohol withdrawal,
as well as clinical outcomes in patients, while also outlining some of the limitations of existing studies
in comparing phenobarbital to benzodiazepines.

Methods:
PubMed, Ovid MEDLINE, and Cochrane databases were searched using the terms phenobarbital,
barbiturates, and alcohol withdrawal syndrome. Prospective and retrospective trials comparing
phenobarbital with benzodiazepines to treat alcohol withdrawal in English were included.

Results:
Two prospective randomized controlled and eleven retrospective cohort trials were identified.
Phenobarbital is safe alone and as an adjunct to benzodiazepine in the emergency department, intensive
care units, general medical units and acute trauma surgery service. In a randomized controlled trial,
one dose of phenobarbital in the emergency department significantly reduced the intensive care
admission rate. There is some evidence that phenobarbital may be effective in the treatment of benzodiazepine-
refractory alcohol withdrawal.

Conclusion:
Although existing knowledge and practice regarding phenobarbital for the treatment of
alcohol withdrawal are increasing, there currently remains limited evidence in support of phenobarbital
over benzodiazepines in superior efficacy and outcomes.
Local Differential Privacy in the Medical Domain to Protect Sensitive Information: Algorithm Development and Real-World Validation
Authors: Sung MinDong , Cha Dongchul , Park Yu Rang 
Published: September 2021

Background
Privacy is of increasing interest in the present big data era, particularly the privacy of medical data. Specifically, differential privacy has emerged as the standard method for preservation of privacy during data analysis and publishing.

Objective
Using machine learning techniques, we applied differential privacy to medical data with diverse parameters and checked the feasibility of our algorithms with synthetic data as well as the balance between data privacy and utility.

Methods
All data were normalized to a range between –1 and 1, and the bounded Laplacian method was applied to prevent the generation of out-of-bound values after applying the differential privacy algorithm. To preserve the cardinality of the categorical variables, we performed postprocessing via discretization. The algorithm was evaluated using both synthetic and real-world data (from the eICU Collaborative Research Database). We evaluated the difference between the original data and the perturbated data using misclassification rates and the mean squared error for categorical data and continuous data, respectively. Further, we compared the performance of classification models that predict in-hospital mortality using real-world data.

Results
The misclassification rate of categorical variables ranged between 0.49 and 0.85 when the value of ε was 0.1, and it converged to 0 as ε increased. When ε was between 102 and 103, the misclassification rate rapidly dropped to 0. Similarly, the mean squared error of the continuous variables decreased as ε increased. The performance of the model developed from perturbed data converged to that of the model developed from original data as ε increased. In particular, the accuracy of a random forest model developed from the original data was 0.801, and this value ranged from 0.757 to 0.81 when ε was 10-1 and 104, respectively.

Conclusions
We applied local differential privacy to medical domain data, which are diverse and high dimensional. Higher noise may offer enhanced privacy, but it simultaneously hinders utility. We should choose an appropriate degree of noise for data perturbation to balance privacy and utility depending on specific situations.
Trends in Hidradenitis Suppurativa Disease Severity and Quality of Life Outcome Measures: Scoping Review
Authors: Maghfour Jalal , Sivesind Torunn Elise , Dellavalle Robert Paul , Dunnick Cory 
Published: September 2021

Background
Although there has been an increase in the number of randomized controlled trials evaluating treatment efficacy for hidradenitis suppurativa (HS), instrument measurements of disease severity and quality of life (QoL) are varied, making the compilation of data and comparisons between studies a challenge for clinicians.

Objective
We aimed to perform a systematic literature search to examine the recent trends in the use of disease severity and QoL outcome instruments in randomized controlled trials that have been conducted on patients with HS.

Methods
A scoping review was conducted in February 2021. The PubMed, Embase, Web of Science, and Cochrane databases were used to identify all articles published from January 1964 to February 2021. In total, 41 articles were included in this systematic review.

Results
The HS Clinical Response (HiSCR) score (18/41, 44%) was the most commonly used instrument for disease severity, followed by the Sartorius and Modified Sartorius scales (combined: 16/41, 39%). The Dermatology Life Quality Index (18/41, 44%) and visual analogue pain scales (12/41, 29%) were the most commonly used QoL outcome instruments in HS research.

Conclusions
Randomized controlled trials conducted from 2013 onward commonly used the validated HiSCR score, while older studies were more heterogeneous and less likely to use a validated scale. A few (6/18, 33%) QoL measures were validated instruments but were not specific to HS; therefore, they may not be representative of all factors that impact patients with HS.

Trial Registration
National Institute of Health Research PROSPERO CRD42020209582; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020209582
Profil Distribusi Apotek di Kabupaten Banyumas berdasarkan Sistem Informasi Geografi dan Korelasinya dengan Jumlah Kunjungan dan Resep Tahun 2019
Authors: Manan Abdul , Utami Pri Iswati , Siswanto Agus 
Published: September 2021

The distribution of pharmacies in Indonesia is still becoming a problem. Pharmacies are
mostly available around healthcare facilities such as hospitals, service providers, trade
centers, transportation facilities, and main roads. The study aims to describe the distribution
profile of pharmacies based on Geographic Information System (GIS) analysis and to study the
relation between pharmacy distribution profiles with the number of consumer visits and
prescriptions. The study is conducted in 27 sub-districts in Banyumas Regency, Central Java
using Arc Gis 3.10.2 Software. Pharmacy profile, the number of consumer visits, and
prescriptions at the pharmacy are obtained by distributing research questionnaires to
pharmacists. The results showed that the distribution of pharmacies in the Banyumas Regency
was still dominant in urban areas, which reached 55%. The average distance of pharmacies
was 2.34 km. The research results on the distribution pattern of pharmacies in 27 sub-districts
showed that in 3 districts (11.1%) were grouped in certain areas, in 24 other districts (88.9%),
the pharmacies' distribution had a spread distribution pattern. The conclusion of the research
that the distribution of pharmacies in the Banyumas Regency based on GIS visualization was
still dominant in urban areas and especially in sub-districts around the capital of Banyumas
Regency, Purwokerto. Based on the study, there was a relation between the average distance of
pharmacies and the number of healthcare facilities on consumer visits. There was a relation
between pharmacy density, population density, and the number of healthcare facilities with the
number of prescriptions.
The Effects of Exchange Rates on Zimbabwe’s Exports
Authors: Chimhore Mable , Chivasa Shynet 
Published: September 2021

The study reviewed the effect of exchange rates on exports in Zimbabwe using the Ordinary Least Squares (OLS) technique. The objective of the study was to examine the effects of exchange rate on export growth in Zimbabwe using mainly the multicurrency era data. This is because the exchange rate plays a key role in policy formulation and implementation. The study is significant as understanding the role of exchange rate on export guides policymakers in coming up with the right policy mix to stimulate exports. Using secondary data from ZIMSTAT and World Bank, obtained results from a robust regression showed that South Africa’s exchange rates (SAEXRT) were weakly significant at 10%, South Africa broad money supply (SAM2) was significant at 5% and imports (DDIMP) were important to Zimbabwe’s export growth at 1% level of significance. To increase exports, there is a need for policy shift, shifting from overly focusing on foreign direct investment and increasing gross domestic product (GDP) because empirical results showed that FDI and gross domestic product were not significant in the model. Policies such as trade cooperation between South Africa and Zimbabwe may increase exports given the impact of South Africa's broad money supply on Zimbabwe’s exports.
Desarrollo de una herramienta tecnológica facilitadora de buenas prácticas agrícolas en los pequeños agricultores del Municipio de Argelia
Authors: Gómez-Ramirez Marisol , Mossos-Vivas Nilson , Herrera-Ramírez Rodrigo 
Published: September 2021

En el presente trabajo se tiene como objetivo diseñar e implementar una herramienta tecnológica para el control y seguimiento de las buenas prácticas agrícolas en los pequeños agricultores de frutas y hortalizas en el Valle del Cauca. Se presenta el desarrollo de una investigación del tipo aplicada, que se apoyó en la revisión de la literatura sobre buenas prácticas agrícolas (BPA), el estudio de las entidades y estándares que existían para la certificación de BPA, y encuestas los agricultores sobre el conocimiento y apropiación de herramientas tecnológicas para facilitar las BPA. Se siguieron los pasos de metodología de desarrollo de software ICONIX, que involucra las etapas de análisis de requerimientos, análisis y diseño preliminar, análisis detallado, codificación y pruebas al sistema. Finalmente se desarrolló una aplicación web facilitadora de las BPA que permite el seguimiento a las prácticas agrícolas, incluyendo un registro constante de las tareas que los agricultores realizan sobre sus cultivos, condición indispensable en estos procesos de certificación. La herramienta permite a los pequeños agricultores llevar un mejor manejo de la información de los procesos sobre los cultivos, tener disponibles consultas sobre la trazabilidad de los productos y el histórico de los lotes de la finca.
MENINGKATKAN HASIL BELAJAR SISWA DENGAN MENGGUNAKAN MODEL PEMBELAJARAN COOPERATIVE LEARNING TIPE MAKE A MATCH DALAM PEMBELAJARAN TARI DI SMK NEGERI 3 PADANG
Authors: Sapitri Pebrina , Indrayuda Indrayuda , Astuti Fuji 
Published: September 2021

AbstractThis article aims to describe and explain about the learning outcomes of students in class X of SMK 3 Padang by using Cooperative Learning model, Type Make a Match. This type of research is Classroom Action Resarch. This research was conducted in 2 cycles, three meetings for first cycle and two meetings for second cycle. At the end of the cycle the students were given a test. For collecting the data, the witer used field notes, documentation and written tests. The analysis of learning activities calculated by percentage. Learning activities for students involved during the learning. The result of the study shows that using the Make a Match type with Cooperative Learning model can be used to help students in learning activities in Cultural Arts subject, especially dancing at SMK 3 Padang. Student learning outcomes in cycle II are more increase than the learning outcomes of cycle I. The first cycle was proved that the learning outcomes of class X BDP students in the first cycle got an average score of 65.71 with the criteria "Enough". The second cycle with an average score of 86.16 can be categorized as "Good". It can be concluded that there was an improvement in using The learning outcomes used the Make A Match type with Cooperative Learning model and the target was reached successfully.Keywords: improving learning outcomes, cooperative learning, make a match type.
PENERAPAN METODE SIMULASI UNTUK MENINGKATKAN HASIL BELAJAR SENI TARI SISWA DI KELAS VIII.6 SMP NEGERI 7 PADANG
Authors: Lestari Maryunis , Yuliasma Yuliasma , Susmiarti Susmiarti 
Published: September 2021

AbstractThe article aims to describe the application of simulation methods to improve the learning outcomes of dance in class VIII.6 of SMP Negeri 7 Padang. This type of research is Classroom Action Research (CAR) or Classroom Action Research. The instrument of this study was the researchers themselves and assisted with supporting instruments in the form of observation sheets of student learning activities, knowledge tests (cognitive) and skills tests (psychomotor). The data collection technique used in each cycle is by observing, testing and documenting. The types of data in this study are primary data and secondary data. Student learning outcomes data were analyzed using mean techniques and using individual and group completeness criteria. The results of the study show that the application of simulation learning methods can improve the learning outcomes of Dance VIII.6 grade students at Padang 7 Public Middle School. Learning activities consist of positive activity and negative activity. Positive learning activities are with indicators asking questions, daring to argue, and doing assignments. Negative learning activities that are with indicators do not concern in class and do not go out of class. Learning activities in the first cycle were still low seen in positive activity 62% and negative activity 61%. While the second cycle obtained an average of 85% positive learning activities and negative learning activities 89%. The average learning outcomes in the first cycle were obtained 82 and the average learning outcomes in the second cycle were 89.4. So it was concluded that the application of simulation methods to improve the learning outcomes of Dance in class VIII.6 students at Padang 7 Junior High School had succeeded.Keyword: Application of simulation method, the results of the study, the art of dance