bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blood based biomarkers as predictive factors for hyperprogression
Authors: Yıldırım Hasan Çağrı , Guven Deniz Can , Aktepe Oktay Halit , Taban Hakan , Yilmaz Feride , Yasar Serkan , Aksoy Sercan , Erman Mustafa , Yalcin Suayib , Kilickap Saadettin 
Published: October 2021

Abstract
Purpose

With the widespread use of immunotherapy agents, we encounter treatment responses such as hyperprogression disease (HPD) that we have not seen with previous standard chemotherapy and targeted therapies. It is known that survival in patients with HPD is shorter than in patients without HPD. Therefore, it is important to know the factors that will predict HPD. We aimed to determine the factors that would predict HPD.

Methods

A total of 121 adult metastatic cancer patients treated with immunotherapy for any cancer between were included. Baseline demographics, ECOG performance status, type of tumors, and baseline blood count parameters were recorded. Possible predisposing factors were evaluated with univariate and multivariate analyses.

Results

The median age was 62.28 (interquartile range (IQR) 54.02-67.63) years, and the median follow-up was 12.26 (IQR 5.6-24.36) months. Renal cell carcinoma (33%) and melanoma (33.8%) were most common diagnoses. Twenty patients (16.5%) had a HPD. High LDH level (p:0.001), hypoalbuminemia (p:0.016), NLR>5 (p:0.007) and NSCLC diagnosis (0.026) are at high risk for HPD. Sex (female vs. male, p:0.114), age (>65 vs <65, p:0.772), ECOG (0 vs 1-4, p:0.480), PNI (>45 vs <45, p:0.055), presence of liver metastases (present vs. absent, p:0.752), the line of treatment (1-5, p:0.112) were not found to be associated with hyperprogression.

Conclusions

In this study, we observed HPD in 16.5% of immunotherapy-treated patients and increased HPD risk in patients with high LDH level (p:0.001), hypoalbuminemia (p:0.016), NLR>5 (p:0.007) and NSCLC diagnosis (0.026).
Culturally Adapted Family Intervention for People With Schizophrenia in Indonesia (FUSION): A Development and Feasibility Study Protocol
Authors: Renwick Laoise Jean , Susanti Herni , Brooks Helen , Keliat Budi Anna , Bradshaw Tim , Bee Penny , Lovell Karina 
Published: October 2021

Abstract
Background
Mental illnesses comprise the single largest source of health-related economic burden globally and low-and middle-income countries are disproportionately affected. The majority of people with schizophrenia who need treatment do not receive it and are often wholly reliant on family caregivers for daily care and support. Family interventions have an exceptionally robust evidence base for their efficacy in high resource settings, but it is unknown whether they can produce equivalent effects in some low resource settings where cultural beliefs, explanatory models of illness and contextual socio-economic issues differ.
Methods
This protocol describes methods to culturally adapt and refine an evidence-based, family intervention for relatives and caregivers of people with schizophrenia in Indonesia. The feasibility and acceptability of implementing an adapted, co-produced intervention via task-shifting in primary care settings will be evaluated using the Medical Research Council framework for complex interventions. The development and preliminary testing of the adapted intervention will occur in three phases utilising mixed methods; stakeholder and key informant interviews will inform consensus workshops using nominal group techniques to develop a testable intervention. The feasibility of testing the intervention in a larger trial and the acceptability of the intervention will be explored in a feasibility trial of adapted family interventions compared to standard treatment. Participants in Phase 1 consultation groups will comprise service-users (n = 10-15), carers (n=10-15) and key stakeholders including lay and healthcare workers (n=10-15) and semi-structured interviews with key informants to identify implementation challenges and facilitators (n= 10). Phase 2 participants will include expert stakeholders including experts by experience to achieve consensus on the essential elements of the intervention (n = 20) and a separate group to develop training methods and materials for our task-shifted intervention. Phase 3 will comprise 60 carer-service-user dyads participating in a randomised feasibility trial.
Discussion
National healthcare policy in Indonesia supports the delivery of mental health services in a complex network of primary care centres. This study will provide important information on the feasibility of delivering family interventions for people with schizophrenia via task-shifting in primary care settings in Indonesia.
Characteristics of Soil Nitrogen and Phosphorus in Different Types of Areas in the Pisha Sandstone Region
Authors: Li xuefeng , Rao liangyi , Xu yeqin 
Published: October 2021

Abstract
Little is known about the distribution of N and P in Pisha sandstone soils from different types of areas. In this study, three typical areas in this region, which included the Er Laohu small watershed (soil-covered area), the Tela small watershed (sand-covered area), and the Shibu Ertai small watershed (bare area), were chosen as experimental objects. A total of 27 soil sections were constructed (Took three parts in the upper, middle and lower of each watershed, respectively), and 486 soil samples were taken from different slope positions and slope directions. Bare Pisha sandstone had the highest mean TN concentration of 0.53 g/kg, which was about 45.06–45.30% higher than soil-covered and sand-covered Pisha sandstone. Sand-covered Pisha sandstone had a lower TP concentration of 37.93–40.62% than the bare (5.04 g/kg) and soil-covered (4.64 g/kg) Pisha sandstone. The concentration of AN in the bare Pisha sandstone was 23.98 mg/kg, which was about 2.85-3.85 times higher than that in the sand-covered and soil-covered Pisha sandstone. Ni concentration in bare Pisha sandstone (5.14 mg/kg) was approximately 3–4 times higher compared to soil-covered and sand-covered Pisha sandstone. The AP concentration in soil-covered Pisha sandstone was 7.56 mg/kg, which was about 68–72.21% higher than that in bare and sand-covered Pisha sandstone areas. Overarchingly, our results suggest that different Pisha sandstone types and slope positions significantly affect the spatial distribution of N and P. That has created a greater obstacle for the local population to carry out agricultural activities in the Pisha sandstone region.
Multiple Omics Analysis Reveals E2F5 Predict Prognostic Biomarker in Diffuse Large B-Cell Lymphoma
Authors: Tan Jinshui , Zhong Mengya , Chen Qinwei , Lu Zhen , Zha Jie , Zhou Yong , Li Guowei , Jiang Yirong , Xu Bing 
Published: October 2021

Abstract
Diffuse large B-cell lymphoma (DLBCL) is highly aggressive and fatal hematological malignancy. There are few biomarkers that can be used to predict the survival of DLBCL patients. Therefore, there is an urgent need to find new biological targets to improve the predictive value and sensitive diagnosis of DLBCL.E2F family play an essential role in tumorigenesis, however, remains obscure in DLBCL.E2F transcription factor family(E2Fs) mRNA expression between DLBCL and nonmalignant samples were screened by GEPIA,CCLE and EMBL-EBI. The associated regulation pathway in DLBLC was established using the GeneMANIA,Metascape ,SMATAPP database. Transcription analysis indicated E2F1/4/5/8 mRNA expression was significantly higher in patients and the cell lines.What’s more, the high E2F5/8 expression had significantly lower survival rate. Further functional analysis showed that E2F1/3/5 were hypomethylated in DLBCL,which may associated with patient chemo-resistance. Subsequently,these genes with their co-expression genes mainly formed transcription factor complex, regulated G1/S transition of mitotic cell cycle and through TGF-beta signaling pathway to participate DLBCL tumorigenesis. This results demonstrate that E2F5 were potential prognostic biomarkers for better survival of DLBCL patients.
Low Dose Risperidone Every 3.8 Hours: Superior Efficacy In Treatment of Bipolar Disorders
Authors: Townsend Robert W. 
Published: October 2021

Abstract
Background: This paper presents a previously unpublished Bipolar Disorder treatment using low-dose Risperidone that gives superior-efficacy, prevents overmedication, and prevents medication-induced anxiety and irritability. Standardized other Bipolar Disorder treatments have a failure rate of 82% to 87.1%. When dropouts and poor adherence are combined, only 12.9% to 18% of Bipolar patients adhere to medications within three years. Self-defensive providers primarily blame Bipolar patients for treatment failures. When that bias is removed, failure is due to overmedication and anxiety and irritability caused by medications. This paper shows the neurobiochemical processes that cause those problems. Published prescription-guidelines recommend Risperidone in high amounts that intentionally activate its 9-Hydroxyrisperidone metabolite under auspices that it is virtually the same as Risperidone and lasts for 24 hours. In truth, however, the beneficial Risperidone chemical lasts for four hours and 9-Hydroxyrisperidone agonizes Bipolar-toxic Serotonin. Low-dose Risperidone neutralizes 9-Hydroxyrisperidone.Methods: Low doses of Risperidone were calculated to be therapeutic amounts without causing overmedication, anxiety, and irritability. Doses were calculated to metabolize low plasma concentrations of 9-Hydroxyrisperidone that stay below the neural-activation threshold level. Four-hour-duration low doses of Risperidone were administered every 3.8 hours.Results: 3.8-hour dosing sustained steady benefits by overlapping 15-minute efficacy-onset with the 15-minute termination of each previous dose. Steady transitions between doses and five administrations per day gave therapeutic efficacy for 16 hours. Taking dose #5 at bedtime gave improved sleep.Conclusions: Low doses of Risperidone activate its therapeutic benefits while neutralizing Bipolar-toxic Paliperidone. Low-dose Risperidone every 3.8 hours maintains stability with room for adding occasional extra doses to control exacerbations of symptoms. This study provides a new biochemistry-based Bipolar Disorder treatment that is vitally needed because the failure rate of traditional treatments is too high. Traditional treatments and research are guided by commercial drug manufacturers’ recommendations and data. Traditional treatment dropout and non-adherence rates attest to the immediate need for this paper’s new paradigm of analytic neurobiochemistry.
Preparation and Characterization of Ultra-Thin Dicing Blades With Different Bonding Properties
Authors: Yuan Zewei , Feng Shuang , Wu Tianzheng 
Published: October 2021

Abstract
Ultra-thin dicing blade is usually used to achieve a high precision cutting in semiconductor back-end packaging and assembly. Lots of interactional parameters involving in dicing blade preparation and cutting process bring difficulties to high cutting qualities and good working life of dicing blade. In order to address these problems, this study prepared three kinds of dicing blades and characterized the cutting properties of three dicing blades. It first proposed the abrasive exposure coefficient and tool deviation coefficient to provide parameters for the cutting force model. Then the experimental apparatus was set up to verify the proposed cutting force model. And a series of parameters including feed rate, spindle current, edge chipping coefficient, tool wear amount and grinding performance are used to characterize the comprehensive performance of prepared dicing blades. Finally, the edge morphology was observed under 3D microscope to analysis the hardness of different dicing blades. The theoretical and experimental results indicate that the proposed cutting force model can reflect actual cutting process. There is an inverse proportional function between the shedding of abrasive particles and the hardness of the matrix. The cutting performance of dicing blades is very dependent on the material of workpiece. C-dicing blades presents outstanding comprehensive effects with small chips and good self-sharpening properties.
Stargazin Interaction With Serine Racemase Mediates Cerebral Ischemia/Reperfusion Injury in Rats
Authors: Yuan Xiaqing , Diao Shanshan , Chen Shujun , Lu Jiajie , Shen Haitao , Li Haiying , Li Xiang , Wu Jiang , Liu Chao , Yang Ya , Xue Qun , Fang Qi , Zhao Hongru , Gan Lei , Ni Jianqiang , Lu Haifeng , Zhu Juehua , Chen Gang 
Published: October 2021

Abstract
D-Serine is thought to be involved in N-methyl-D-aspartate (NMDA)-type glutamate receptor-mediated neurotoxicity and plays a pathophysiologic role in stroke. D-Serine is synthesized by serine racemase (SR), which directly converts L-serine into D-serine. The deletion of SR has been reported to protect against cerebral ischemia damage. Additionally, SR catalytic activity is physiologically regulated by its binding to stargazin. However, whether the stargazin-SR interaction affects the level of stroke damage remains elusive. We showed that cerebral ischemia increased the interaction of stargazin and SR and decreased the levels of D-serine. Disrupting the stargazin-SR interaction by knocking down stargazin aggravated cerebral ischemic insults. We found that cerebral ischemia decreased the phosphorylation of stargazin at the Thr-321 residue, which was phosphorylated by cAMP-dependent protein kinase A (PKA). Treatment with the PKA inhibitor H89 blocked stargazin T321 phosphorylation, augmented the stargazin-SR interaction, decreased D-serine levels, and alleviated focal cerebral ischemic damage in rats subjected to middle cerebral artery occlusion and reperfusion (MCAO/R). Thus, the stargazin-SR interaction is a promising strategy in the treatment of stroke.
The appeal of ‘Do It Yourself’ orthodontic aligners: A YouTube analysis
Authors: Collins Megan , Luc Darwin , Karadeniz Ersan , Petocz Peter , Flores-Mir Carlos , Karadeniz Carmen 
Published: October 2021

Abstract
Objective: The present study aimed to determine how the popularity of ‘Do It Yourself’ (DIY) aligner videos available on YouTube relates to authorship, video content, quality and reliability, and to determine why DIY aligners appeal to consumers.
Methods: The Google Trends website was interrogated to identify the most frequently used search terms regarding DIY aligners which were subsequently applied to a search of the YouTube website. One hundred twenty-three videos were assessed for completeness of content, reliability (using a modified version of the DISCERN tool) and quality using the Global Quality Score (GQS). The relationship between the variables and authorship, popularity, financial interest, and recommendations were assessed using Pearson Correlation Coefficients.
Results: Laypeople produced the majority of the videos (73%). Dentists/Orthodontists uploaded only 4% of the videos, and dental professional bodies uploaded none. Most videos (86%) were content poor, unreliable (average DISCERN score of 1) and of low quality (average GQS of 2). The more popular, reliable and superior the quality of the video, the greater the number of views, likes and viewing rate (p < 0.05). Conversely, authors with a financial interest and lower quality and less reliable videos were more likely to recommend DIY aligners. Consumers sought DIY aligner treatment due to a reduced cost.
Conclusions: YouTube should not be considered as a viable nor reliable source of DIY aligner information for patients or the public. Dentists/Orthodontists should be encouraged to publish comprehensive and more informative YouTube content related to DIY aligners.
Oxygen-fugacity evolution of magmatic Ni-Cu sulfide deposits in East Kunlun: Insights from Cr-spinel composition
Authors: Jia Lihui , Chen Yi , Su Bin , Mao Qian , Zhang Di 
Published: October 2021

Abstract
In this study, we use Cr-spinel as an efficient indicator to evaluate the oxygen fugacity evolution of the Xiarihamu Ni-Cu deposit and the Shitoukengde non-mineralized intrusion. Oxygen fugacity is calculated using an olivine-spinel oxybarometer, with spinel Fe3+/ΣFe ratios determined by a secondary standard calibration method using an electron microprobe. Cr-spinel Fe3+/ΣFe ratios of the Xiarihamu Ni-Cu deposit vary from 0.32 ± 0.09 to 0.12 ± 0.01, corresponding to magma fO2 values ranging from ΔQFM+2.2 ± 1.0 to ΔQFM-0.6 ± 0.2. By contrast, those of the Shitoukengde mafic-ultramafic intrusion increase from 0.07 ± 0.02 to 0.23 ± 0.04, corresponding to magma fO2 varying from ΔQFM-1.3 ± 0.3 to ΔQFM+1.0 ± 0.5. A positive correlation between fO2 and Cr-spinel Fe3+/ΣFe ratios suggests that the Cr-spinel Fe3+/ΣFe ratios can be used as an indicator for magma fO2. The high fO2 (QFM+2.2) of the harzburgite in the Xiarihamu Ni-Cu deposit suggests that the most primitive magma was characterized by relatively oxidized conditions, and then became reduced during magmatic evolution, causing S saturation and sulfide segregation to form the Xiarihamu Ni-Cu deposit. The evolution trend of the magma fO2 can be reasonably explained by metasomatism in mantle source by subduction-related fluid and addition of external reduced sulfur from country gneisses (1.08–1.14 wt% S) during crustal processes. Conversely, the primitive magma of the Shitoukengde intrusion was reduced and gradually became oxidized (from QFM-1.3 to QFM+1.0) during crystallization. Fractional crystallization of large amounts of Cr-spinel can reasonably explain the increasing magma fO2 during magmatic evolution, which would hamper sulfide precipitation in the Shitoukengde intrusion. We propose that the temporal evolution of oxygen fugacity of the mantle-derived magma can be used as one of the indicators for evaluating metallogenic potential of Ni-Cu sulfide deposits and the reduction processes from mantle source to shallow crust play an important role in the genesis of magmatic Ni-Cu sulfide deposits.
Start-up strategies for nitrification and manganese oxidation on a single stage RSF for drinking water production
Authors: Etcheberry Thomas , Peyre Lavigne Matthieu , Trias Rosalia , Brunner Stéphane , Torres Zuluaga Juan , Di Gioia Lodovico , Paul Etienne 
Published: October 2021

Abstract
In drinking water production from groundwaters, biological rapid sand filters (RSFs) can be used for ammonium and manganese removal in aerobic conditions. However, in some boreholes, a start-up duration of several months is required to reach the required removal capacity, leading to significant water losses. Moreover, in specific industrial cases, no exogenous biomass under the form of backwash water or activated sludge can be added to accelerate the process, and different approaches are seldom considered in the literature. With the aim of saving water, start-up strategies coupling water temperature increase and substrate dosing were studied to accelerate the installation of biological activities in a pilot plant fed with borehole water. These set-ups enabled a substantial acceleration of nitrification but no improvement of manganese oxidation in the experimental conditions, although the experiments showed no clear negative influence of nitrification, through nitrite accumulation, on biological manganese oxidation. To further save energy and reduce water loss, outlet water recirculation at a rate of 75% during the start-up phase was validated. The proposed start-up strategy enabled the complete installation of active biofilms with a mean start-up time reduction of 36% and water use reduction of 84% compared to the reference natural conditions.
Speed Track Events: Development and Validity of Exercise Catalog
Authors: Soares Gabriel , Motta-Santos Daisy , Costa Varley , Pedrosa Gustavo , Silva Ronaldo , Scotti Andre , Prudêncio Marcio , Gonçalves Reginaldo , Szmuchrowski Leszek 
Published: October 2021

Introduction:
Sports coaches are guided by empirical evidence at the moment of planning the training loads, and, many times, these loads are not recorded for posterior analysis. A validated scientific instrument could help coaches to plan, register, and analyse sports training load.

Aim:
The study aimed to develop and assess the content validity of a catalog of exercises for speed track events.

Methods:
Through interviews, a group of expert coaches elaborated a catalog of exercises. Two groups of raters evaluated the content validity of these exercises, producing a coefficient of content validity (CCV) for such validity indicators as clarity of language, practical pertinence and theoretical relevance. Additionally, raters assessed the specificity level of each exercise by deciding if the exercise was general, special or specific to speed track events.

Results:
These CCV results confirmed the content validity of a 75-exercise catalog with satisfactory validity indicators, meaning the exercises are understandable for athletic coaches (CCVCL=0,93), pertinent for speed track training (CCVPP=0,84) and relevant (CCVRT=0,83).

Conclusion:
This catalog may help athletic coaches to plan, implement and analyze their players’ sports training loads.
The coping strategies of community pharmacists and pharmaceutical services provided during COVID-19 in Malaysia
Authors: Kua Kok Pim , Lee Shaun 
Published: October 2021

Background The coronavirus disease 2019 (COVID-19) pandemic has
resulted in profound health challenges across the globe. Pharmacists’
readiness to cope with the pandemic is critical in supporting and
sustaining the healthcare workforce to meet the challenges.
Objective This study aims to examine community pharmacists’
views on their work environment, policies, and preparedness for safe
retail patronage to prevent the transmission of COVID-19 and assess the
variables influencing coping strategies during the pandemic.
Setting An online survey of pharmacists practicing in community
pharmacy setting in Malaysia.
Method A questionnaire-based, cross-sectional study was
conducted in Malaysia to evaluate coping strategies of community
pharmacists and pharmaceutical services provided during COVID-19
pandemic. Between May 1 and July 31, 2020, the questionnaire was
distributed to pharmacists working in community setting nationwide
utilizing a snowball sampling method.
Main outcome measure Community pharmacists’ perceptions on
safety, resilience, organizational support, and pharmaceutical services
offered during COVID-19 pandemic.
Results A total of 217 pharmacists participated in the study.
The vast majority of community pharmacists reported a positive outlook
and were able to balance working with self-care during this period. Most
reported to have access to personal protective equipment such as gloves
and hand sanitizers. A large proportion of community pharmacies also
installed physical barriers in doorways or in front of the counter, put
markings on the ground to section areas to ensure physical distancing,
and controlled the number of customers who could access the pharmacy
during this period. Innovations reported to be implemented included
teleconsultations and providing curb-side or drive-through delivery and
pickup services.
Conclusion The findings suggest the frontline and essential
roles of community pharmacists in delivering pandemic responses,
creating the opportunity to determine areas where community pharmacy
services can be incorporated to strengthen the public health system and
improve patient health outcomes.