bluuebunny/crossref_metadata_2025_split huggingface dataset:
An in vitro approach to combat multidrug resistance in Salmonella typhi and human colon cancer with Excoecaria agallocha L. extract
Authors: Sultana Tamanna , Mitra Arup Kumar , Das Satadal 
Published: December 2021

Abstract
Background
The incidence of antibacterial resistance and colon cancer is increasing in India. Antibacterial resistance and chemoresistance demand the need of developing herbal or natural chemotherapeutic agents. Our study thus, aims to determine the antibacterial and anticancer activities of the leaf extracts of the mangrove Excoecaria agallocha.

Results
Liquid chromatography–mass spectroscopy analysis of the ethanolic E. agallocha extracts revealed the presence of Bergenin. The plant extract fraction containing Bergenin had potent antibacterial action against a resistant strain of Salmonella typhi with an MIC value of 15.7 ± 0.04 µg/mL. Treatment of the bacteria with the plant extract made it moderately susceptible to the antibacterial drugs ampicillin, aztreonam, cefotaxime, chloramphenicol and imipenem. The plant extract caused membrane damage and disrupted the expression of a 33 kDa outer membrane protein (OmpA) in S. typhi. It was plausibly due to this mechanism of the plant extract that made the bacteria susceptible to the antibacterial drugs to a certain extent. Further, fluorescence microscopy analysis revealed the anticancer property of the extract against a human colon cancer (DLD-1) cell line by activation of Caspase-3followed by subsequent apoptosis and exhibited cytotoxicity against the cancerous cell line with an IC50 value of 17.99 ± 1.12 µg/mL. Caspase-3 activity was observed to increase in a dose-dependent manner as determined by spectrophotometric assays. Moreover, the expression of the metalloproteinase-7 (MMP-7) was significantly reduced in plant extract treated DLD-1 colon cancer cells.

Conclusion
The results indicate that E. agallocha is a novel source of Bergenin, and the plant extract fraction under study may be used in combination therapy along with antibacterial drugs to combat antibacterial resistance of S. typhi and also to alleviate the risks of colon cancers in human. However, further investigations may be undertaken for its therapeutic application and to explore its potential bioactivity against other bacterial strains and human cancer cell lines.
Learning needs assessment for multi-stakeholder implementation science training in LMIC settings: findings and recommendations
Authors: Turner Mallory Wolfe , Bogdewic Stephanie , Agha Erum , Blanchard Carrie , Sturke Rachel , Pettifor Audrey , Salisbury Kathryn , Marques Andrea Horvath , Excellent Marie Lina , Rajagopal Nitya , Ramaswamy Rohit 
Published: December 2021

Abstract
Background
Despite significant progress in the field of implementation science (IS), current training programs are inadequate to meet the global need, especially in low-and middle-income countries (LMICs). Even when training opportunities exist, there is a “knowledge-practice gap,” where implementation research findings are not useful to practitioners in a field designed to bridge that gap. This is a critical challenge in LMICs where complex public health issues must be addressed. This paper describes results from a formal assessment of learning needs, priority topics, and delivery methods for LMIC stakeholders.

Methods
We first reviewed a sample of articles published recently in Implementation Science to identify IS stakeholders and assigned labels and definitions for groups with similar roles. We then employed a multi-step sampling approach and a random sampling strategy to recruit participants (n = 39) for a semi-structured interview that lasted 30–60 min. Stakeholders with inputs critical to developing training curricula were prioritized and selected for interviews. We created memos from audio-recorded interviews and used a deductively created codebook to conduct thematic analysis. We calculated kappa coefficients for each memo and used validation techniques to establish rigor including incorporating feedback from reviewers and member checking.

Results
Participants included program managers, researchers, and physicians working in over 20 countries, primarily LMICs. The majority had over 10 years of implementation experience but fewer than 5 years of IS experience. Three main themes emerged from the data, pertaining to past experience with IS, future IS training needs, and contextual issues. Most respondents (even with formal training) described their IS knowledge as basic or minimal. Preferences for future training were heterogeneous, but findings suggest that curricula must encompass a broader set of competencies than just IS, include mentorship/apprenticeship, and center the LMIC context.

Conclusion
While this work is the first systematic assessment of IS learning needs among LMIC stakeholders, findings reflect existing research in that current training opportunities may not meet the demand, trainings are too narrowly focused to meet the heterogeneous needs of stakeholders, and there is a need for a broader set of competencies that moves beyond only IS. Our research also demonstrates the timely and unique needs of developing appropriately scoped, accessible training and mentorship support within LMIC settings. Therefore, we propose the novel approach of intelligent swarming as a solution to help build IS capacity in LMICs through the lens of sustainability and equity.
Improved production of titanate nanotubes by hydrothermal method for adsorption of organic dyes
Authors: Zaki Ayman H. , Adel Sara , Abd El-hafiez Mahmoud M. , Abdel-Khalek Ahmed A. 
Published: December 2021

AbstractBackgroundIncreasing the yield of nanomaterials using the same reactor size and fixing most of the reactants and conditions will greatly improve the production process by saving time, energy and efforts. Titanate nanotubes are mainly prepared by hydrothermal process, in which TiO2powder reacts with NaOH at certain conditions to form the desired nanotubes. It was reported that it is a must to use high concentrations of NaOH (10 N) to enable the tubular form formation, and the amount of NaOH from the stoichiometry point of view is much higher than that of TiO2; this means excess amounts of NaOH are not used and washed off. This work was designed to improve the production yield by making use of this excess amount of NaOH.ResultsMore than 60 g of sodium titanate nanotubes was prepared using simple hydrothermal method. The prepared nanotubes were characterized by X-ray powder diffraction, high-resolution transmission electron microscopy, Fourier-transform infrared spectroscopy and BET surface area analysis. The adsorption capacity of these nanotubes was tested against three commonly used dyes: methyl orange, crystal violet and thymol blue. The samples showed great affinity toward crystal violet and lower activity toward methyl orange and thymol blue, where they achieved more than 90% removal efficiency under different experimental conditions.ConclusionsSodium titanate nanotubes were prepared in large amounts using modified hydrothermal method. The obtained nanotubes efficiently removed crystal violet from water. This improved synthesis of titanate nanotubes will reduce the total cost of nanomaterials production, and subsequently the treatment process, since titanate nanotubes are used in adsorption and photocatalysis processes.
Simple spectrophotometric methods for the determination of amlodipine and atorvastatin in bulk and tablets
Authors: Abu Reid Imad Osman , Farid Hind Mohamed , Eltayeb Sara Osman 
Published: December 2021

Abstract
Background
Simultaneous spectrophotometric determination of samples containing more than one analyte presents analytical challenge; the choice of an analytical procedure is strictly related to the extent of overlapping between the individual absorption peaks of these components; if the absorption peaks are satisfactorily resolved, the determination is not problematic, but if the individual component signals are partly or totally overlapped, then powerful techniques are needed. Combined amlodipine and atorvastatin are typical example where special techniques are needed to resolve bands overlapping.

Results
Application of multiwavelength regression and absorbance factor methods to the analysis of atorvastatin and amlodipine combination proved to be satisfactorily capable of accurate and precise determination of the two analytes. The two methods recoveries were very close to the expected analytes concentrations, and the precision of the methods was < 2% relative standard deviation. Statistical comparison indicated that there is no significant difference between the assay results obtained by the two method as the calculated t values 0.91 and 1.13 for amlodipine and atorvastatin, respectively, were less than the tabulated t value 2.23 at 95% confidence level.

Conclusion
The proposed methods are accurate, precise, simple and inexpensive. They can be applied successfully to the analysis of the two drugs in combined dosage form.
Characterization of novel stress degradation products of Bempedoic acid and Ezetimibe using UPLC–MS/MS: development and validation of stability-indicating UPLC method
Authors: Vejendla Anuradha , Talari Subrahmanyam , Ramu G. , Rajani Ch 
Published: December 2021

Abstract
Background
A receptive and easily comprehended technique was evolved for simultaneous assessment of Bempedoic acid and Ezetimibe and its impurities characterized by UPLC–MS/MS.

Results
This technique involves chromatographic separation with a C18 column of water symmetry (150 mm × 4.6 mm, 3.5 µm). A mobile phase of 0.1% OPA (orthophosphoric acid) and acetonitrile in 50:50 v/v with 1 mL/min flow rate and ambient temperature was used. UV observation was taken at 230 nm. The recoveries, linearity, and quantification limits were found to be within the acceptable limit.

Conclusions
This technique was successfully tested with UPLC–MS to confirm the chemical structures of newly formed degradation products of Bempedoic acid and Ezetimibe and stress studies as per ICH Q2 (R1) guidelines.
Audiological findings of a patient with H syndrome: case report
Authors: Hussein Diala , Altın Büşra , Bajin Münir Demir 
Published: December 2021

Abstract
Background
H syndrome is an autosomal recessive disorder caused by mutations in SLC29A3. Hyperpigmentation, hypertrichosis, hyperglycemia, and hearing loss are some characteristics of this disorder, and it has a prevalence of < 1/1000. The aim of this report is to spread awareness among otologists, audiologists, and pediatricians about this syndrome and its audiological features.

Case presentation
An 8-year-old male with a diagnosed H syndrome registered to our clinic with a complaint of hearing loss. The patient was diagnosed with hearing loss in a different clinic using only the air-conducted click auditory brainstem response test which showed wave V at 60 dB nHL for the right ear and at 80 dB nHL for the left ear. The initially performed pure tone audiometry (PTA) test in our clinic revealed a bilateral asymmetric hearing loss with a moderate sensorineural hearing loss in the right ear and a profound mixed hearing loss in the left ear. The performed air conducted click auditory brainstem response (ABR) result showed wave V at 55 dB nHL for the right ear and at 70 dB nHL for the left ear. Then, the repeated PTA test revealed a mild-severe sensorineural sloping hearing loss in the right ear and a severe sensorineural hearing loss in the left ear.

Conclusion
Although hearing thresholds in H syndrome could be within normal limits in some patients, sensorineural hearing loss is an important characteristic feature for this syndrome. Sensorineural hearing loss could be progressive or of sudden onset and ranges from mild to profound. Thus, it must be taken into consideration to apply the audiological follow-up regularly and paying attention to the patient’s complaints; also, a regular follow-up for language development of children with H syndrome and for the hearing aids is advised.
Hydrologic changes of in-situ gravimetry
Authors: Zhang Min , Liu Ziwei , Wu Qiong , Teng Yuntian , Zhang Xiaotong , Du Feibai , Jiang Ying 
Published: December 2021

Inter-seasonal and geodynamics-related gravity changes are important geoscientific signals that are extractable from gravimeter observations after removing background information as local hydrology gravity effect. With two superconducting gravimeters (SGs: OSG-053 and iGrav-007) located in different tectonic units, continuous global navigation satellite system data and absolute gravity observations, Wuhan, China, is an ideal location for investigating the effects of gravity resulting from significant local hydrology mass variations. We have processed approximately 26 months of gravity data collected from the SGs in Wuhan and obtained residuals of [Formula: see text] for OSG-053 and [Formula: see text] for iGrav-007. The hydrological observations indicate an estimated gravity increase of [Formula: see text] near iGrav-007, which mainly results from an increase in unconfined water level with an aquifer-specific yield of approximately 0.1. However, the gravity changes around OSG-053 are mainly from soil moisture and reach −[Formula: see text]. The soil type, thickness, and water content parameters are obtained from hydrogeological surveys and drilling data. The deep confined water level rises by 2.5 m, which introduces a [Formula: see text] gravity variation with a specific storage approximately 0.00001 from the field unsteady-flow pumping test. The modeled gravity is approximately [Formula: see text] around OSG-053 and [Formula: see text] around iGrav-007, in accordance with the observed gravity variations. The difference in gravity changes between the two SG observations can be explained by different local water storage environments. Our results suggest that unconfined and soil water significantly impact the in-situ gravimetry, and that further detailed hydrogeological surveys are required. A combined investigation of gravity and water levels can be a useful approach for monitoring aquifer storage conditions and groundwater management.
Mental health issues related to climate change in Poland - Polish psychologists’ and psychotherapists’ perspective.
Authors: Gawrych Magdalena , Holka-Pokorska Justyna 
Published: December 2021

Aim of the studyThe aim of the first Polish pilot study was to conduct an initial analysis of the occurrence of mental issues related to such experiences as: fear, worry, sense of loss and grief in connection with climate change and ecology. The consequences of climate and environmental changes for physical health are increasingly well-documented. In contrast, psychosocial changes due to climate change and, in particular, the impact on mental health, remain unrecognized.Subject or material and methodsPsychologists and psychotherapists were asked to share their clinical experience in diagnosing and treatment of patients reporting climate change-related mental symptoms. Climate change-related mental issues were operationalized as clinically significant symptoms meeting the criteria for anxiety and depressive disorders or adjustment disorders, and are known in literature as a solastalgia and ecological anxiety. The collection of data with the use of an on-line survey started lasted 4 months.ResultsIssues relating to ecology and climate change were present both in the contents of patient concerns (48.6% of respondents) and in patients’ hypotheses regarding their symptoms (16.7% of respondents, p <.001) in the past 6 months of the respondents’ clinical work. Mental health professionals considered psychoeducation (62.5%), psychological support (73.6%), short-term psychotherapy (45.8%) and self-help groups (40.3%) to be appropriate mental health support interventions.DiscussionThe presented study provides evidence that mental health issues related to climate change are recognized by Polish psychologists and psychotherapists. The professionals can need comprehensive knowledge of climate-related mental health, including appropriate interventions.ConclusionsThese findings may be a ground for designing further research on this topic.
Kajian Potensi Bencana Kebumian Wilayah Kecamatan Ngombol, Kabupaten Purworejo, Provinsi Jawa Tengah
Authors: Zainun Zainun , Hidajat Wahju Krisna , Santi Narulita 
Published: December 2021

Kecamatan Ngombol, Kabupaten Purworejo terletak di bagian selatan Provinsi Jawa Tengah yang merupakan salah satu wilayah rawan bencana. Sejak tahun 2008 hingga tahun 2018 terhitung sebanyak 125 kejadian bencana alam di Kabupaten Purworejo. Sebagai langkah awal meminimalkan dampak negatif dari potensi terjadinya bencana alam, dilakukan kajian dan pemetaan zonasi rawan bencana kebumian di daerah Kecamatan Ngombol. Penelitian dilakukan untuk mengetahui faktor-faktor yang berperan terhadap potensi bencana kebumian dan mengetahui zonasi tingkat rawan bencana kebumian di daerah tersebut. Penentuan zona rawan bencana kebumian menggunakan metode overlay dari skor tiap parameter masing-masing bencana. Parameter zona rawan gempabumi meliputi kondisi geologi berupa pasir, kemiringan lereng terdiri dari datar hingga sangat curam, nilai intesitas gempa sebesar II MMI, dan jauh dari zona sesar. Hasil parameter zona rawan banjir berupa tanah aluvial untuk jenis tanah, kemiringan lereng terdiri dari datar hingga sangat curam, nilai curah hujan infiltrasi sebesar 3.245,93 mm.hari/tahun, penggunaan lahan berupa sawah, pemukiman, kebun, ladang, semak belukar dan pasir, nilai kerapatan sungai kurang dari 0,62 km/km2 hingga lebih dari 3,1 km/km2. Kecamatan Ngombol tergolong sebagai kawasan tipologi A untuk zona rawan gempabumi. Zona rawan banjir terbagi menjadi 3 kelas yaitu 2% zona tidak rawan, 47% zona cukup rawan dan 51% zona sangat rawan.
The concept of cone b-Banach space and fixed point theorems
Authors: Yang Chen , Zhu Xiaolin 
Published: December 2021

Abstract
In this article, the concepts of cone b-norm and cone b-Banach space are given. Some new fixed point theorems in cone b-Banach spaces are established. The new results improve some fixed point theorems in cone Banach spaces. Furthermore, we also investigate the uniqueness of fixed points.
Some new parameterized inequalities for co-ordinated convex functions involving generalized fractional integrals
Authors: Kalsoom Humaira , Budak Hüseyin , Kara Hasan , Ali Muhammad Aamir 
Published: December 2021

Abstract
In this study, we first obtain a new identity for generalized fractional integrals which contains some parameters. Then by this equality, we establish some new parameterized inequalities for co-ordinated convex functions involving generalized fractional integrals. Moreover, we show that the results proved in the main section reduce to several Simpson-, trapezoid- and midpoint-type inequalities for various values of parameters.
Solution of integral equations via coupled fixed point theorems in 𝔉-complete metric spaces
Authors: Mani Gunaseelan , Gnanaprakasam Arul Joseph , Lee Jung Rye , Park Choonkil 
Published: December 2021

Abstract
The concept of coupled 𝔉-orthogonal contraction mapping is introduced in this paper, and some coupled fixed point theorems in orthogonal metric spaces are proved. The obtained results generalize and extend some of the well-known results in the literature. An example is presented to support our results. Furthermore, we apply our result to obtain the existence theorem for a common solution of the integral equations:

ζ

(

v

)

=
ð

(

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)

+

∫

0

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(

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)

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ζ

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ξ

(

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∈

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,

\left\{\begin{array}{ll}\zeta \left({\mathfrak{v}})=&#x00F0;\left({\mathfrak{v}})+\underset{0}{\overset{{\mathfrak{M}}}{\displaystyle \int }}\Xi \left({\mathfrak{v}},\beta )\Omega \left(\beta ,\zeta \left(\beta ),\xi \left(\beta )){\rm{d}}\beta ,& {\mathfrak{v}}\in \left[0,{\mathscr{H}}],\\ \xi \left({\mathfrak{v}})=&#x00F0;\left({\mathfrak{v}})+\underset{0}{\overset{{\mathfrak{M}}}{\displaystyle \int }}\Xi \left({\mathfrak{v}},\beta )\Omega \left(\beta ,\xi \left(\beta ),\zeta \left(\beta )){\rm{d}}\beta ,& {\mathfrak{v}}\in \left[0,{\mathscr{H}}],\end{array}\right.

where

(a)

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:
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→
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and

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:
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→
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are continuous;

(b)

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:
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×
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\Xi :{\mathfrak{M}}\times {\mathfrak{M}}

is continuous and measurable at

β
∈
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,

∀

\beta \in {\mathfrak{M}},\hspace{0.33em}\forall

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∈
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;

(c)

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(

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≥
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and

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(

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≤
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,

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∈
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{\int }_{0}^{{\mathscr{H}}}\Xi \left({\mathfrak{v}},\beta ){\rm{d}}\beta \le 1,\hspace{0.33em}\forall {\mathfrak{v}}\in {\mathfrak{M}}

.
Symmetric pairs and pseudosymmetry of Θ-Yetter-Drinfeld categories for Hom-Hopf algebras
Authors: Liu Wei , Fang Xiaoli 
Published: December 2021

Abstract
In this paper, we investigate a more general category of

Θ

\Theta

-Yetter-Drinfeld modules (

Θ
∈
Aut

H

(

H

)

\Theta \in {\rm{Aut}}\hspace{0.33em}H\left(H)

) over a Hom-Hopf algebra, which unifies two different definitions of Hom-Yetter-Drinfeld category introduced by Makhlouf and Panaite, Li and Ma, respectively. We show that the category of

Θ

\Theta

-Yetter-Drinfeld modules with a bijective antipode

S

S

is a braided tensor category and some solutions of the Hom-Yang-Baxter equation and the Yang-Baxter equation can be constructed by this category. Also by the method of symmetric pairs, we prove that if a

Θ

\Theta

-Yetter-Drinfeld category over a Hom-Hopf algebra

H

H

is symmetric, then

H

H

is trivial. Finally, we find a sufficient and necessary condition for a

Θ

\Theta

-Yetter-Drinfeld category to be pseudosymmetric.
Structural Performance of Fusion Weld Based on Weld Parameters and Strain Rate in High-Density Polyethylene
Authors: Faraz Ahmed , Zai Behzad Ahmed , Nisar Salman , Mansoor Asif , Ali Rashid 
Published: December 2021

Abstract
Use of high-density polyethylene (HDPE) material has increased considerably in the last few decades to form long installation lengths of buried infrastructure such as water mains, sewers, and gas pipelines. These pipes are available in standard length sections and joined together to get customized length using fusion-welding techniques. The strength of welds highly depends on welding parameters such as temperature, heat, and soaking time. The structural performance also varies with respect to strain rate. In this paper, the strength of fusion-welded HDPE material is analyzed under different welding parameters and variable strain rates of welded and unwelded samples. An additional important aspect of the present research is to study the structural performance of fusion welds made between extruded HDPE pipes and injection molded HDPE fittings, i.e., elbows, Tee joints and closed-end cap connections. The strain-rate sensitivity index is measured with variable strain rates during tensile testing. The findings of this research can help in understanding and improving the structural performance of HDPE fusion-welded joints in various applications.