bluuebunny/crossref_metadata_2025_split huggingface dataset:
Upaya Meningkatkan Kemampuan Fisik Motorik Halus Anak Kelompok A Melalui Kegiatan Melipat dengan Media Kertas
Authors: Murwani Yennik 
Published: June 2021

Penelitian ini bertujuan untuk meningkatkan keterampilan fisik motorik halus pada anak usia dini dengan menggunakan media melipat kertas.Subjek penelitian ini adalah anak kelompok A yang berjumlah 12 anak. Dengan rincian jumlah anak putra 3 anak dan jumlah putri 9 anak. Objek penelitian ini adalah kegiatan pembelajaran melipat kertas dengan cara mendemontrasikan.Jenis penelitian adalah Penelitian Tindakan Kelas yang terdiri dari dua siklus,setiap siklus terdiri dari perencanaan,observasi, pelaksanaan dan refleksi. Teknik pengumpulan data dengan observasi, dokumentasi, wawancara, dan hasil karya. Hasil penelitian menunjukan bahwa terjadi peningkatan prosentase awalnya pada pra siklus anak sebesar 40% pada siklus I sebesar 60% pada siklus II prosentase meningkat menjadi 80%. Kesimpulannya kegiatan melipat kertas kelompok A dapat meningkatkan hasil belajar pada anak TK Al Islam 7 surakarta.
Dampak Kepemimpinan, Iklim Sekolah dan Motivasi Berprestasi Dalam Meningkatkan Komitmen Guru
Authors: Lukman Hakim  , Lian Bukman , Putra Alhadi Yan 
Published: June 2021

The purpose of this study was to determine and analyze the effect of significantly leadership principal, school climate and commitment achievement motivation to teachers at SMK Sub Rayon 04 in Ogan Komering Ulu Timur regency of South Sumatra province either partially or simultaneously. This study was a quantitative descriptive research, the population in this study are all public school teachers in the SMK Sub Rayon 04 in Ogan Komering Ulu Timur regency of South Sumatra province 330 teacher, with a sample of 101 teachers. Data was collected by questionnaire. Analysis of data using path analysis (path analysis) and hypothesis testing. The results of this study indicated that Leadership Principal significantly influence teachers' commitment, school climate significant effect on teacher commitment, achievement motivation significant effect on the school climate of teachers. Leadership principal, school climate, achievement motivation jointly significant effect on commitment of teacher.
Keywords: Motivation, commitment, leadership, climate.
Tujuan penelitian ini adalah untuk mengetahui dan menganalisis pengaruh signifikan kepemimpinan kepala sekolah, iklim sekolah dan motivasi berprestasi terhadap komitmen guru di SMK Sub Rayon 04 Kabupaten Ogan Komering Ulu Timur Provinsi Sumatera Selatan baik secara parsial maupun secara simultan. Penelitian ini termasuk dalam jenis penelitian deskriptif kuantitatif, populasi pada penelitian ini adalah seluruh guru SMK Sub Rayon 04 Kabupaten Ogan Komering Ulu Timur Provinsi Sumatera Selatan sebanyak 330 guru, dengan sampel 101 guru. Pengumpulan data dilakukan dengan kuisioner. Analisis data menggunakan analisis jalur (path analysis) dan pengujian hipotesis. Hasil penelitian ini menunjukkan bahwa kepemimpinan kepala sekolah berpengaruh signifikan terhadap komitmen guru, iklim sekolah berpengaruh signifikan terhadap komitmen guru, motivasi berprestasi berpengaruh signifikan terhadap komitmen guru. Kepemimpinan kepala sekolah, iklim sekolah, motivasi berprestasi secara bersama-sama berpengaruh signifikan terhadap komitmen guru.
Kata Kunci: Iklim, kepemimpinan, komitmen, motivasi,
CHROME Criteria and Quality of Life: A Pilot Study from Maria Wolff-Albertia
Authors: Muñiz Ruben , López-Álvarez Jorge , Perea Luis , Rivera Sofía , González Liliana , Olazarán Javier 
Published: June 2021

Background: Over- and potentially inappropriate prescribing of psychotropic medications is a major public health concern among people with dementia. Objective: Describe the CHemical Restraints avOidance MEthodology (CHROME) criteria and evaluate its effects on psychotropic prescribing and quality of life (QoL). Methods: Observational, prospective, two-wave study conducted in two nursing homes. A multicomponent program to eliminate chemical restraints and attain quality prescription of psychotropic medications was implemented. CHROME’s diagnostic criteria comprise constellations of behavioral and psychological symptoms of dementia under six primary syndromic diagnoses. Since pharmacologic treatment is aimed at only one syndrome, polypharmacy is avoided. Psychotropic prescription, QoL, neuropsychiatric symptoms (NPS), and other clinical measurements were collected before and one year after the intervention. Results are presented for all residents ( n = 171) and for completer subjects ( n = 115). Results: Mean age (SD) of the residents was 87.8 (5.7), 78.9% were women, and 68.5% suffered advanced dementia. Psychotropic prescriptions decreased from 1.9 (1.1) to 0.9 (1.0) ( p < 0.0005). Substantive reduction in prescribing frequency was observed for antidepressants (76.9% pre-intervention, 33.8% post-intervention) and for atypical neuroleptics (38.8% pre-intervention, 15.1% post-intervention). There was improvement in patient’s response to surroundings ( p < 0.0005) and total NPS ( p < 0.01), but small worsening occurred in social interaction ( p < 0.02, completer subjects). Safety measurements remained stable. Conclusion: CHROME criteria appear to optimize psychotropic prescriptions, avoid chemical restraints, and allow external verification of quality prescriptions. Extensive use seems feasible, related to substantial reduction of prescriptions, and of benefit for people with dementia as de-prescriptions are not associated to increased NPS or QoL loss.
Classification, Prediction, and Concordance of Cognitive and Functional Progression in Patients with Mild Cognitive Impairment in the United States: A Latent Class Analysis
Authors: Mouchet Julie , Betts Keith A. , Georgieva Mihaela V. , Ionescu-Ittu Raluca , Butler Lesley M. , Teitsma Xavier , Delmar Paul , Kulalert Thomas , Zhu JingJing , Lema Neema , Desai Urvi 
Published: June 2021

Background: Progression trajectories of patients with mild cognitive impairment (MCI) are currently not well understood. Objective: To classify patients with incident MCI into different latent classes of progression and identify predictors of progression class. Methods: Participants with incident MCI were identified from the US National Alzheimer’s Coordinating Center Uniform Data Set (09/2005-02/2019). Clinical Dementia Rating (CDR®) Dementia Staging Instrument-Sum of Boxes (CDR-SB), Functional Activities Questionnaire (FAQ), and Mini-Mental State Examination (MMSE) score longitudinal trajectories from MCI diagnosis were fitted using growth mixture models. Predictors of progression class were identified using multivariate multinomial logistic regression models; odds ratios (ORs) and 95% confidence intervals (CIs) were reported. Results: In total, 21%, 22%, and 57% of participants (N = 830) experienced fast, slow, and no progression on CDR-SB, respectively; for FAQ, these figures were 14%, 23%, and 64%, respectively. CDR-SB and FAQ class membership was concordant for most participants (77%). Older age (≥86 versus≤70 years, OR [95% CI] = 5.26 [1.78–15.54]), one copy of APOE ɛ4 (1.94 [1.08–3.47]), higher baseline CDR-SB (2.46 [1.56–3.88]), lower baseline MMSE (0.85 [0.75–0.97]), and higher baseline FAQ (1.13 [1.02–1.26]) scores were significant predictors of fast progression versus no progression based on CDR-SB (all p < 0.05). Predictors of FAQ class membership were largely similar. Conclusion: Approximately a third of participants experienced progression based on CDR-SB or FAQ during the 4-year follow-up period. CDR-SB and FAQ class assignment were concordant for the vast majority of participants. Identified predictors may help the selection of patients at higher risk of progression in future trials.
Novel multi-criteria decision-making methods with soft rough q-rung orthopair fuzzy sets and q-rung orthopair fuzzy soft rough sets
Authors: Riaz Muhammad , Ali Nawazish , Davvaz Bijan , Aslam Muhammad 
Published: June 2021

The aim of this paper is to introduce the concepts of soft rough q-rung orthopair fuzzy set (SRqROFS) and q-rung orthopair fuzzy soft rough set (qROPFSRS) based on soft rough set and fuzzy soft relation, respectively. We define some fundamental operations on both SRqROFS and qROPFSRS and discuss some key properties of these models by using upper and lower approximation operators. The suggested models are superior than existing soft rough sets, intuitionistic fuzzy soft rough sets and Pythagorean fuzzy soft rough sets. These models are more efficient to deal with vagueness in multi-criteria decision-making (MCDM) problems. We develop Algorithm i (i = 1, 2, 3, 4, 5) for the construction of SRqROFS, construction of qROFSRS, selection of a smart phone, ranking of beautiful public parks, and ranking of government challenges, respectively. The notions of upper reduct and lower reduct based on the upper approximations and lower approximations by variation of the decision attributes are also proposed. The applications of the proposed MCDM methods are demonstrated by respective numerical examples. The idea of core is used to find a unanimous optimal decision which is obtained by taking the intersection of all lower reducts and upper reducts.
Epidemiology and pathogenesis of stroke in preterm infants: A systematic review
Authors: Roy B. , Walker K. , Morgan C. , Finch-Edmondson M. , Galea C. , Epi M. , Badawi N. , Novak I. 
Published: June 2021

BACKGROUND: Perinatal stroke is one of the principal causes of cerebral palsy (CP) in preterm infants. Stroke in preterm infants is different from stroke in term infants, given the differences in brain maturation and the mechanisms of injury exclusive to the immature brain. We conducted a systematic review to explore the epidemiology and pathogenesis of periventricular hemorrhagic infarction (PVHI), perinatal arterial ischemic stroke (PAIS) and cerebral sinovenous thrombosis (CSVT) in preterm infants. METHODS: Studies were identified based on predefined study criteria from MEDLINE, EMBASE, SCOPUS and WEB OF SCIENCE electronic databases from 2000 –2019. Results were combined using descriptive statistics. RESULTS: Fourteen studies encompassed 546 stroke cases in preterm infants between 23 –36 weeks gestational ages and birth weights between 450 –3500 grams. Eighty percent (436/546) of the stroke cases were PVHI, 17%(93/546) were PAIS and 3%(17/546) were CSVT. Parietal PVHI was more common than temporal and frontal lobe PVHI. For PAIS, left middle cerebral artery (MCA) was more common than right MCA or cerebellar stroke. For CSVT partial or complete thrombosis in the transverse sinus was universal. All cases included multiple possible risk factors, but the data were discordant precluding aggregation within a meta-analysis. CONCLUSION: This systematic review confirms paucity of data regarding the etiology and the precise causal pathway of stroke in preterm infants. Moreover, the preterm infants unlike the term infants do not typically present with seizures. Hence high index of clinical suspicion and routine cUS will assist in the timely diagnosis and understanding of stroke in this population.
Using ultrasound for screening scoliosis to reduce unnecessary radiographic radiation – a prospective diagnostic accuracy study on 442 schoolchildren
Authors: Pang H , Wong YS , Yip BHK , Hung ALH , Chu WCW , Lai KKL , Zheng YP , Chung TWH , Sharma G , Cheng JCY , Lam TP 
Published: June 2021

Scoliosis screening is important for timely initiation of brace treatment to mitigate curve progression in skeletally immature children. Scoliosis screening programs frequently include the protocol of referring children screened positive with Scoliometer and Moiré Topography for confirmatory standard radiography. Despite being highly sensitive (88%) for detecting those who require specialist referral, the screening program was found to have more than 50% false positive rate that leads to unnecessary radiation exposure. Radiation-free ultrasound has been reported to be reliable for quantitative assessment of scoliosis curves. The aim of this prospective diagnostic accuracy study was to determine the accuracy of ultrasound in determining the referral status for children initially screened positive for scoliosis. 442 schoolchildren with a mean Cobb angle of 14.0 ± 6.6° were recruited. Using x-ray as the gold standard, the sensitivity and specificity of ultrasound in predicting the correct referral status were 92.3% and 51.6% respectively. ROC curve analysis revealed an area under curve of 0.735 for ultrasound alone and 0.832 for ultrasound plus scoliometer measurement. The finding provided strong evidences on the accuracy of ultrasound in determining the referral status that could result in more than 50% reduction of unnecessary radiation exposure for children undergoing scoliosis screening.
Significance of BRAFV600E mutation in intra-axial brain tumor in Malaysian patients: case series and literature review
Authors: Mohamed Yusoff A.A. , Abd Radzak S.M. , Mohd Khair S.Z.N. , Abdullah J.M. 
Published: June 2021

Summary. Background: To date, BRAF mutations in brain tumor patients have not been characterized in the Malaysian population. Based on the numerous reported studies, there are main mutations that exist in BRAF gene in various types of cancers. A missense mutation in codon 600 of the BRAF nuclear oncogene (BRAFV600E) is the most prevalent hotspot point mutation that has been identified in multiple human malignancies. Aim: We here aimed to find out the frequency of BRAFV600E mutation in a series of Malaysian patients with brain tumors and if any association exists between BRAFV600E mutation and clinicopathological features of patients. Material and Methods: Fresh frozen tumor tissue samples from 50 Malaysian brain tumor patients were analyzed for BRAFV600E mutational status, and its correlation with clinicopathological features (including age, gender, and tumor localization such as intra-axial: within the brain substance or extra-axial: outside the brain substance) was examined. Results: The overall BRAFV600E mutation frequency was determined to be 22% (in 11 of 50 patients). BRAFV600E was significantly correlated with the tumor location group, which shows BRAFV600E was more frequent in the intra-axial tumor than the extra-axial tumor group. In this study, we also observed that male patients were slightly more susceptible to BRAFV600E mutation, and this mutation was predominant in patients of the age group < 40 years. However, these parameters did not translate to statistical significance. Conclusion: The data demonstrate that BRAFV600E mutation is observed significantly more often in intra-axial brain tumor patients, which can serve as baseline information for further research on genetic alteration that occurs during brain tumor progression in the Malaysian population.
Co-administration of apigenin with doxorubicin enhances anti-migration and antiproliferative effects via PI3K/PTEN/AKT pathway in prostate cancer cells
Authors: Ayyildiz A. , Koc H. , Turkekul K. , Erdogan S. 
Published: June 2021

Summary. Prostate cancer is one of the leading cancers in men, and new approaches are needed for its treatment. The aim of this study was to investigate the effect of co-administration of naturally occurring flavone apigenin and doxorubicin to androgen-insensitive prostate cancer cells. Methods: The effect of the treatment on survival and migration of human PC3 cells was evaluated by MTT and scratch assay, respectively. Apoptosis and cell cycle distribution were detected by image-based cytometry. mRNA and protein expression were determined by real-time quantitative polymerase chain reaction and Western blot, respectively. Results: Apigenin and doxorubicin dose-dependently inhibited cell survival, and co-administration of both agents significantly induced cell death via upregulating the mRNA expression of caspases, Bax and cytochrome c, and downregulating Bcl-XL. Combination therapy caused cell cycle arrest by upregulating the expression of p21 and p27. The treatment modality inhibited cell migration via downregulating Snail, Twist and MMPs in which doxorubicin was ineffective. Apigenin dephosphorylated Akt strongly, significantly suppressed ERK phosphorylation, and increased PTEN expression 4.5-fold. The combination of apigenin and doxorubicin inhibited PI3K and AKT phosphorylation more strongly than a single administration. Conclusions: Our data indicate that a combination of the natural flavone apigenin with doxorubicin might have a potential in treatment of castration-resistant prostate cancer.
Study of modifying effects of astaxanthin on cytogenetic manifestations of bystander response in human peripheral blood lymphocytes in vitro
Authors: Pilinska M.A. , Shemetun O.V. , Talan O.О. , Dibska O.B. , Talko V.V. 
Published: June 2021

Summary. Aim: To study the possible impact of astaxanthin on the cytogenetic manifestations of the simultaneous development of radiation-induced (RIBE) and tumor-induced bystander effect (TIBE) in human peripheral blood lymphocytes. Materials and Methods: Peripheral blood lymphocytes from healthy persons and patients with chronic lymphocytic leukemia were cultured separately or cocultured with or without previous irradiation in vitro by 137Cs at a dose of 0.5 Gy. The cells were cultured with and without 20 μg/ml astaxanthin. Results: In the presence of astaxanthin, the decrease of chromosomal instability both in the variant with separate TIBE and with simultaneous development of TIBE and RIBE was observed as the reduction in the frequency of simple chromosome-type aberrations, namely, double fragments. The average level of chromatid-type aberrations did not change under the action of astaxanthin. Although the total chromosome instability in bystander cells diminished, this did not lead to the elimination of the RIBE and TIBE development in the presence of astaxanthin. Conclusion: In the setting of experiment, astaxanthin did not reduce the frequency of chromatid-type aberrations in bystander cells due to RIBE and TIBE but reduced the frequency of simple aberrations of chromosomal type, not associated with the development of bystander response phenomenon.
5-FU resistant colorectal cancer cells possess improved invasiveness and βIII-tubulin expression
Authors: Akalovich S. , Portyanko A. , Pundik A. , Mezheyeuski A. , Doroshenko T. 
Published: June 2021

Summary. Background: Elevated βIII-tubulin levels are associated with resistance to a broad spectrum of drugs in different carcinomas and with poor prognosis of various epithelial cancers. 5-Fluorouracil (5-FU) is a widely used standard drug in chemotherapeutic regimens for colorectal cancer treatment, although the resistance to 5-FU is a major obstacle to successful therapy. Aim: The aim of the study was to compare the invasive and adhesion properties and the expression levels of βIII-tubulin in a 5-fluorouracil (5-FU)-resistant colorectal cancer (CRC) cell line HCT116 and parental cells. Materials and Methods: The 5-FU-resistant cell line was established by continuous stepwise selection with increasing concentrations of 5-FU. Cell viability and properties were evaluated using MTT, adhesion and Transwell invasion assays, respectively. The expression of βIII-tubulin was revealed by immunoblot and immunofluorescence. Results: The derivative line is 25-fold more resistant to 5-FU and characterized by altered cell morphology. Twice as many cells of the 5-FU-resistant line fail to adhere as compared to the parental cell line. 5-FU-resistant cells are characterized by enhanced invasiveness, accompanied with the increased βIII-tubulin expression. In addition, we found that loss of βIII-tubulin expression was correlated with loss of 5-FU resistance. Conclusion: Our results indicate that even though 5-FU does not target microtubules, there appears to be a correlation between βIII-tubulin expression and resistance to 5-FU that is particularly important with regard to invasiveness. These findings indicate a possible contribution of βIII-tubulin to 5-FU resistance in vivo.
Malpraktik Pemilu dan Korupsi: Analisis terhadap Proses Penghitungan dan Rekapitulasi pada Pemilu Indonesia 2019
Authors: Husin Luthfi Hamzah , Pratama Heroik Mutaqin , Prasetyo Wegik , Hendra Hendra , Darmawan Wawan Budi , Manan Firman , Amsari Feri 
Published: June 2021

Penelitian ini mencoba untuk mengkaji hubungan antara malpraktik pemilu dengan korupsi dengan berfokus pada analisis terhadap penyimpangan di dalam proses penghitungan dan rekapitulasi suara pada Pemilu Indonesia 2019, dengan fokusan pemilihan legislatif. Penelitian ini mencoba mengisi kekosongan literatur yang mengkaji malpraktik pemilu di Indonesia yang lebih banyak dilihat pada tahapan kampanye ketimbang tahapan penghitungan dan rekapitulasi suara di mana peran penyelenggara pemilu menjadi sangat sentral. Untuk menganalisis hal tersebut, penelitian ini menganalisis secara lebih spesifik pada keterlibatan Komisi Pemilihan Umum (KPU) sebagai penyelenggara pemilu di dalam malpraktik pemilu. Menggunakan metode analisis dokumen dan studi kasus, penelitian ini menemukan bahwa tahapan rekapitulasi suara, khususnya pada tingkat kecamatan, merupakan fase paling rawan terjadinya malpraktik pemilu di mana keterlibatan penyelenggara pemilu ad-hoc dan saksi kandidat memiliki peran penting di sana.
Gambaran idiopathic osteosclerosis gigi molar ketiga impaksi pada radiograf Cone Beam Computed Tomography
Authors: Dananjaya Agung Anak Agung Gde , Lestarini Ni Ketut Ayu 
Published: June 2021

Objectives: To analyze idiopathic osteosclerosis radiographs associated with impacted third molars (M3) on cone beam computed tomography (CBCT).
Case Report: A 36-year-old woman came to the Dentology Clinic complaining that the right mandibular third molar area often felt sore. The patient was referred for CBCT examination and incidentally, a radiopaque image with clear boundaries, irregular shape was found on the periapical impacted third molar without caries in the tooth crown. The treatment plan that will be carried out on the tooth is extraction.
Conclusion: Idiopathic osteosclerosis lesions are lesions that occur in vital teeth that have the characteristics of a well-defined radiopaque appearance and are asymptomatic. Characteristics of idiopathic osteosclerosis lesions can be visualized by CBCT well. CBCT has the advantage of being able to display a detailed picture of the lesion in three dimensions (3D) with a fairly good image resolution.
Actitud estudiantil ante el plagio y la conciencia para evitarlo
Authors: Izquierdo Alejandro Edrei del Carmen , Magaña Medina Deneb Elí , Quijano García Román Alberto 
Published: June 2021

El objetivo de esta investigación fue determinar las actitudes hacia el plagio de los estudiantes de contabilidad de una universidad pública del sureste de México, y los principales factores que lo predicen. La población del estudio se conformó por una muestra no probabilística representativa de 200 estudiantes de contaduría pública. Se desarrolló un cuestionario denominado Percepción del estudiante universitario sobre el plagio (PEUP), que fue validado por expertos, y presenta valores aceptables de fiabilidad (a > .70). Su estructura teórica fue confirmada a través del análisis factorial exploratorio y confirmatorio. Los resultados indican que 10.5% de los estudiantes aceptan no dar crédito a los autores originales cuando realizan sus asignaciones académicas, pero 41% de la población encuestada reconoce tener conciencia sobre la importancia del plagio y cómo evitarlo. Los resultados de la regresión lineal jerárquica señalan que la conciencia para evitar el plagio es el factor que explica la mayor parte de las actitudes personales hacia el mismo (B = .39, p = .000), seguido de las competencias para evitarlo (B = .33, p = .000); y por último, las condiciones percibidas por el estudiante que le permiten realizarlo (B = .27, p = .000). Se concluye que la conciencia del estudiante sobre el plagio es el principal predictor del mismo, lo cual reafirma la premisa de que el plagio es un asunto de ética y valores, tanto individuales como colectivos.