bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation on Sensing and Stability of Nitrogen-doped ITO Thin-film Strain Gauges at High Temperatures
Authors: Liu Zhichun , Liang Junsheng , Li Jian , Zhou Hao , Yang Mingjie , Cao Sen , Lu Wenqi , Xu Jun 
Published: September 2021

Abstract
Nitrogen-doped indium tin oxide (ITO) has been applied in the thin-film strain gauges (TFSGs) due to their high stability, excellent piezoresistivity and antioxidation at elevated temperatures. However, the mechanism on the sensing and stability of the nitrogen-doped ITO TFSGs at high temperatures was not comprehensively clarified. In this work, various ITO TFSGs were fabricated by RF magnetron sputtering with different nitrogen partial pressures (NPPs) of 5%~40%. The elemental composition and band structures of the ITO TFSGs were examined by the energy dispersive X-ray spectroscopy (EDS) and X-ray photoelectron spectroscopy (XPS), respectively. Results show that the Fermi energy level shifts closer to the valence band maximum energy (Ev) gradually with the growth of NPPs, causing a reduction in the number of electrons ionized to the conduction band. The smallest content change rates of nitrogen (3.8%) and oxygen (1.6%) after subjecting to the thermal strain test were observed in the 20%N2 ITO TFSG. In consequence, the 20%N2 ITO TFSG exhibits the lowest resistance drift rate (DR) at high temperatures due to its stable elemental composition. Moreover, we found that the band structures and elemental composition of the ITO TFSGs are the main factors affecting their piezoresistive response at different temperatures. The band structures play a major role in the gauge factors (GFs) of the ITO TFSGs at room temperature and 600 ℃. The element variation takes responsibility for the different GFs of the ITO TFSGs at 800℃, 900℃ and 1000℃. In addition, the piezoresistive stability is also dependent on the elemental composition affected by the dynamic equilibrium between the diffusion amount of oxygen and the escape number of the nitrogen in the ITO thin films at high temperatures.
Adoptive cell therapy targeting common p53 neoantigens in human solid cancers
Authors: Kim Sanghyun , Vale Nolan , Zacharakis Nikolaos , Krishna Sri , Yu Zhiya , Gasmi Billel , Gartner Jared , Sindiri Sivasish , Malekzadeh Parisa , Deniger Drew , Lowery Frank , Parkhurst Maria , Ngo Lien , Ray Satyajit , Li Yong , Hill Victoria , Florentin Maria , Paria Biman , Levin Noam , Hedges Elizabeth , Choi Agnes , Chatani Praveen , Levi Shoshana , Seitter Samantha , Lu Yong-Chen , Zheng Zhili , Prickett Todd , Jia Li , Hernandez Jonathan , Hoang Chuong , Robbins Paul , Goff Stephanie , Sherry Richard , Yang James , Rosenberg Steven 
Published: September 2021

Abstract
Adoptive cell therapy (ACT) targeting neoantigens can achieve durable clinical responses in patients with cancer. Most neoantigens arise from rare mutations, requiring highly individualized treatments. To broaden the applicability of ACT targeting neoantigens, we focused on TP53 mutations commonly shared across different cancer types. Here, we describe a library of T cell receptors (TCRs) that can target TP53 mutations shared among 7.3% of patients with solid cancers. These TCRs recognized tumor cells in a TP53 mutation- and human leucocyte antigen (HLA)-specific manner both in vitro and in vivo. Patients with chemorefractory epithelial cancers treated with ex vivo-expanded autologous tumor infiltrating lymphocytes (TILs) naturally reactive with mutant p53 experienced limited clinical responses (2 PRs/12 patients), and we detected low frequencies, exhausted phenotypes, and poor persistence of the infused mutant p53-reactive TILs. Alternatively, we treated one patient with a chemorefractory breast cancer with ACT by transducing autologous peripheral blood lymphocytes with an HLA-A*02-restricted anti-p53R175H TCR. The infused cells exhibited an improved immunophenotype and prolonged persistence compared to the TIL ACT and the patient experienced an objective tumor regression (-55%) that lasted 6 months. Collectively, these data demonstrate the feasibility of off-the-shelf TCR-engineered cell therapies targeting shared p53 neoantigens to treat human cancers.
Potential Risks for and Prognoses After Infections and Antimicrobial use Among Hemodialysis Outpatients: A Prospective Study
Authors: Zhang Jing-Jing , Wu Yi-le , Hu Xiao-Qian , Xu Wen-Ting , Li Huai , Fang Mei , Yuan Liang , Li Ruo-Jie , Wang Xue-Ping , Wang De-Guang , Yang Xi-Yao 
Published: September 2021

Abstract
Background: The aims of this study were to determine the prevalence and characteristics of infections as well as the use of antimicrobials among hemodialysis outpatients. Methods: We used the dialysis event surveillance protocol to conduct a prospective study in 2019. Results: Totally 180 outpatients who received maintenance hemodialysis were included in the cohort study. The total number of dialysis events was 53 in 38 patients. Among the collected events, 42 (79.25%) events used intravenous antimicrobial treatments; five (9.43%) had positive blood cultures; and six (11.32%) had pus, redness, or swelling at the access site. Type of vascular access was an influencing factor for infection among hemodialysis outpatients. Blood flow rate on dialysis was another factor influencing infection events, the risk of infection increased in patients who had lower blood flow rate. Additional analysis showed that lower blood flow rate was also observed as adverse impact in patients who used central lines, but not in those with fistulas. And Erythropoietin use was higher in the infection group. Conclusions: Patients who used central lines, and especially patients both with central lines and low blood flow rate, were more vulnerable to infection. Using Erythropoietin was another risk factor for infection in hemodialysis outpatients.
Seismological and Engineering Characteristics of Strong Motion Data from 24 and 26 September 2019 Marmara Sea Earthquakes
Authors: Malcıoğlu Fatma Sevil , Süleyman Hakan , Çaktı Eser 
Published: September 2021

Abstract
An MW 4.5 earthquake took place on September 24, 2019 in the Marmara Sea. Two days after, on September 26, 2019, Marmara region was rattled by an MW5.7 earthquake. With the intention of compiling an ample strong ground motion data set of recordings, we have utilized the stations of Istanbul Earthquake Rapid Response and Early Warning System operated by the Department of Earthquake Engineering of Boğaziçi University and of the National Strong Motion Network operated by AFAD. All together 438 individual records are used to calculate the source parameters of events; namely, corner frequency, radius, rupture area, average source dislocation, source duration and stress drop. Some of these parameters are compared with empirical relationships and discussed extensively. Duration characteristics are analyzed in two steps; first, by making use of the time difference between P-wave and S-wave onsets and then, by considering S-wave durations and significant durations. It is observed that they yield similar trends with global models. PGA, PGV and SA values are compared with three commonly used ground motion prediction models. At distances closer than about 60 km observed intensity measures mostly conform with the GMPE predictions. Beyond 60 km their attenuation is clearly faster than those of GMPEs. Frequency-dependent Q models are developed for both events. Their consistency with existing regional models are confirmed.
Proteomics to Metabolomics: A New Insight Into the Pathogenesis of Hypertensive Nephropathy
Authors: Eshraghi Yasin , Abedi Maryam , Gheisari Yousof 
Published: September 2021

Abstract
Background

Hypertensive nephropathy (HN) is a high burden disorder and a leading cause of end-stage renal disorder. In spite of huge investigations, the underlying mechanisms are yet largely unknown. Systems biology is a promising approach to provide a comprehensive insight towards this complex disorder.
Methods

Protein expression profiles of kidney tubule and cortex sub-compartments were retrieved from the PRIDE database and the quality of the datasets were assessed using principal component analysis (PCA) and hierarchical clustering. Differentially expressed proteins (DEPs) were detected and their attributed metabolites were enriched and their interactions were assessed in multi-layer networks. Moreover, considering the DEPs and the predicted metabolites, key biomedical phenomena with a leading role in HN pathogenesis were proposed.
Results

Amino acid and purine metabolisms are the most prominent alteration in kidney cortex whereas dysregulation of energy hemostasis is a key pathogenic mechanism in tubule. Besides, actin cytoskeleton disorganization is an enriched pathway in both anatomical areas.
Conclusion

The proteomics profiles of kidney sub-compartments were analyzed using a top-down approach to infer the main pathogenic processes. The constructed holistic map of HN can be exploited to propose novel therapeutic strategies.
miR-27b-3p Targeting BDNF Inhibits the TrkB/CREB Signaling Pathway and Improves IL-1 β-Induced Chondrocyte Inflammation
Authors: ruan cailian , CONG Rui jun , Wang Miao , WANG LI JUN , YU YONG , LI XIAO JI , JIANG XIAOFENG 
Published: September 2021

Abstract
Background: Explore the mechanism of "miR-27b-3p targeting BDNF inhibits the TrkB/CREB signaling pathway and improves IL-1 β-induced chondrocyte inflammation".Methods: The animal and cell models of arthritis were constructed, and various biochemical detection methods were used to detect the changes of apoptosis, inflammation and oxidative stress.Results: The results showed that the expression of miR-27b-3p was downregulated in IL-1β-treated chondrocytes and cartilage tissues isolated from a KOA rat model. miR-27b-3p overexpression notably reduced IL-1β-induced chondrocyte apoptosis and the expression levels of caspase-3 and caspase-9. In addition, cell transfection with miR-27b-3p mimics increased the mRNA and protein expression levels of inducible nitric oxide synthase and cyclooxygenase-2. The levels of nitric oxide, prostaglandin E2 (PGE2), TNF-α and IL-6 were also reduced following cell transfection with miR-27b-3p mimics. Furthermore, bioinformatics analysis predicted that miR-27b-3p could directly target brain-derived neurotrophic factor (BDNF). Additionally, the present study suggested that the tropomyosin receptor kinase B (TrkB)/cAMP response‑element binding protein (CREB) signaling axis could be a downstream pathway of the miR-27b-3p/BDNF axis. The percentage of apoptotic cells and the expression levels of nitric oxide, PGE2, TNF-α and IL-6 were enhanced in chondrocytes co-treated with BDNF + IL-1β. However, these effects were restored following transfection of chondrocytes with miR-27b-3p mimics. Staining of cartilage tissues with safranin O showed that miR-27b-3p overexpression Significantly attenuated KOA-induced cartilage degradation.Conclusions:miR-27b-3p targeting BDNF inhibits the TrkB/CREB signaling pathway and improves IL-1 β-induced chondrocyte inflammation.
Molecular Dynamics Simulations on the Thermal Effect of Interfacial Friction During Asperity Shearing
Authors: Yuan Zhaoxun , Zhao Junxian , Huang Shiping 
Published: September 2021

Abstract
To explore the thermal effect of interfacial friction at the nano/microscale, a solid-solid contact model of a rough surface with a single peak was established to research single-crystal Fe. The friction characteristics, stress distributions, temperature changes, and energy changes under different indentation depths and lattice orientations during the shearing process were analyzed. From the perspective of temperature and energy, the mechanism of the thermal effect was revealed. The relationship between the friction force, temperature, and energy at the atomic scale was clarified. The results showed that the temperature of the asperities gradually increased during the shearing process, and a stress concentration formed in the shearing zone. After contact, the asperities had undergone unrecoverable plastic deformation, and there was wear at the contact interface accompanied by the loss of atoms from the asperity. At each indentation depth, as the rotation angle of the crystal increased, the friction force, average temperature, and the sum of the changes in thermal kinetic and thermal potential energy all first increased and then decreased; the trends of the three parameters changing with the rotation angle of the crystal were consistent. The average decreases in the friction force, average temperature, and the sum of the changes in thermal kinetic and thermal potential energy were 52.47%, 30.91%, and 56.75%, respectively, for a crystal structure with a rotation angle of 45° compared to a crystal structure with a rotation angle of 0°. The methods used in this study provide a reference for the design of frictional pairs and the reduction of the thermal effect of interfacial friction.
H+/K+ Ion Pump Enhances Cytoskeletal Polarity to Drive Gastrulation in Sea Urchin Embryo
Authors: Watanabe Kaichi , Yasui Yuhei , Kurose Yuta , Fujii Masashi , Yamamoto Takashi , Sakamoto Naoaki , Awazu Akinori 
Published: September 2021

Abstract
Gastrulation is a universal process in the morphogenesis of many animal embryos. In sea urchin embryos, it involves the invagination of a single-layered vegetal plate into the blastocoel. Although morphological and molecular events in gastrulation have been well studied, the mechanical driving forces and the regulatory mechanism underlying gastrulation is not fully understood. In this study, structural features and cytoskeletal distributions were studied in sea urchin embryos using an “exogastrulation” model induced by inhibiting the H+/K+ ion pump with omeprazole. The vegetal poles of the exogastrulating embryos showed reduced roundness indices, intracellular pH polarization, and intracellular F-actin polarization at the pre-early gastrulation stage compared with normal embryos. Gastrulation stopped when F-actin polymerization or degradation was inhibited via RhoA or YAP1 knockout, although pH distributions were independent of such a knockout. A mathematical model of sea urchin embryos at the early gastrulation reproduced the shapes of both normal and exogastrulating embryos using cell-dependent cytoskeletal features based on F-actin and pH distributions. Thus, gastrulation required appropriate cell position-dependent intracellular F-actin distributions regulated by the H+/K+ ion pump through pH control.
Enhanced Photoluminescence Properties of BaAl2O4: Ce3+/Li+ Yellow Phosphors
Authors: K Ganesh Kumar , Bhargav Balaji , Aravinth K , C Balaji 
Published: September 2021

Abstract
Ce3+/ Li+ activated barium aluminate phosphor (BAO) was synthesized by conventional solid-state reaction method. The crystal structure of the synthesized phosphor was analyzed by X-ray diffraction (XRD) and Raman spectroscopy analysis. FT-IR spectrum results revealed the characteristic vibration bands present in the synthesized phosphor. Surface composition analysis of the prepared samples was examined using X-ray photoelectron spectroscopy (XPS). PL emission band observed at 589 nm was assigned to 5D excited level corresponding to 2F5/2 transition in yellow region under the excitation wavelength of 320 nm. Yellow light emission was confirmed by the Commission Internationale de L’Eclairage (CIE) chromatic coordinate graph. The color purity of BAO: 0.5Ce3+, BAO: 0.5Ce3+, 0.1Li+ was found to be 78.4 %, 81.3 % whereas the measured lifetime was 4.333, 4.738 ns respectively.
Selection of Remote Sensing Images And Evapotranspiration Models On Complex Land Surfaces for a Humid Karst Catchment
Authors: Zhang Rongfei 
Published: September 2021

Abstract
Evapotranspiration (ET) is predominant variable for water management in various types of ecosystems, and ET processes in these ecosystems have been assessed through in-situ measuring and modelling methods. However, it is challenging to measure actual ET and upscale it to regional level. In addition, the accuracy of retrieved parameters from models is usually low for karst landscapes, where the underlying surface is more complex than non-karst landscapes. Due to various porosities and conduits, aquifers in karst landscapes typically show remarkable and rapid responses to precipitation events, leading to serious water stress. Therefore, there is an urgent need to quantify water fluxes to provide reliable evidence for the protection and sustainable management of karst water resources. In this study, five plots were built to observe actual ET based on Thermal Dissipation Probes (TDP), re-designed Ventilated-chamber and Micro-lysimeters in a karst catchment in southwest China. Then, three models (Penman-Monteith-Leurning, PML; Remote Sensing-Priestley and Taylor, RS-PT; and Hargreaves) were selected to upscale ET estimation to the regional level based on Landsant-8 and MODIS data. The results showed that: 1) The PML model performed better than other models (p < 0.01) with higher R2 values (0.72 for MODIS images and 0.87 for Landsat-8 images) and smaller RMSE values (1.4 mm·day-1 and 0.8 mm·day-1 for MODIS and Landsat-8 images, respectively); 2) Daily ET exhibited significant seasonal variability and different spatial distribution; 3) ET had a slightly positive correlation with DEM; however, ground temperature had a negative correlation with ET. By combining remote sensing data and upscaling it to the regional level, this study helps improve the accuracy of measured and estimated ET. It suggests that ET is strongly regulated by vegetation coverage and available energy in subtropical humid karst catchments.
Identifying and addressing conflicting results across multiple discordant systematic reviews on the same topic: A protocol for a replication study of the Jadad algorithm
Authors: Lunny Carole , Thirugnanasampanthar Sai Surabi , Kanji Salman , Ferri Nicola , Pieper Dawid , Whitelaw Sera , Thabet Pierre , Tasmin Sara , Nelson Harrison , Reid Emma , Zhang Jia He (Janet) , Kalkat Banveer , Chi Yuan , Thompson Jacqueline Y , Abdoulrezzak Reema , Zheng Di Wen (Wendy) , Pangka Lindy R.S. , Wang Dian (Xin Ran) , Safavi Parisa , Sooch Anmol , Kang Kevin T. , Tricco Andrea C 
Published: September 2021

Abstract
Introduction: An increasing growth of systematic reviews (SRs) presents notable challenges for decision-makers seeking to answer clinical questions. Overviews of systematic reviews aim to address these challenges by summarising results of SRs and making sense of potentially discrepant SR results and conclusions. In 1997, an algorithm was created by Jadad to assess discordance in results across SRs on the same topic. Since this tool pre-dates the advent of overviews, it has been inconsistently applied in this context. Our study aims to (a) replicate assessments done in a sample of overviews using the Jadad algorithm to determine if the same SR would have been chosen, (b) evaluate the Jadad algorithm in terms of utility, efficiency, and comprehensiveness, and (c) describe how overviews address discordance in results across multiple SRs. Methods and Analysis: We will use a database of 1218 overviews (2000-2020) created from a bibliometric study as the basis of our search for overviews assessing discordance. This bibliometric study searched MEDLINE (Ovid), Epistemonikos, and Cochrane Database for overviews. We will include any overviews using Jadad (1997) or another method to assess discordance. The first 30 overviews screened at the full-text stage by two independent reviewers will be included. We will replicate Jadad assessments in overviews. We will compare our outcomes qualitatively and evaluate the differences between our Jadad assessment of discordance and the overviews’ assessment. Ethics and Dissemination: No ethics approval was required as no human subjects were involved. In addition to publishing in an open-access journal, we will disseminate evidence summaries through formal and informal conferences, academic websites, and across social media platforms. This is the first study to comprehensively evaluate and replicate Jadad algorithm assessments of discordance in SRs.
The effect of small-scale irrigation on household food security of Kindo Didaye District, Wolaita Zone, Southern Ethiopia
Authors: Bakalo Israel Balta , Assele Desalegn Dawit , Mohamed Nejuma , Ayele Abayneh 
Published: September 2021

Abstract
This study aimed to assess the effect of small-scale irrigation on household food security in the Kindo Didaye district. Community-based comparative cross-sectional survey was conducted at Kindo Didaye district, Wolaita zone from September 1st to 30, 2020. Data were collected by using structured questionnaires from 160 irrigation users and 163 non-users. Binary logistic regression analyses were fitted to identify factors associated with household food security. The prevalence of household food security was (87.5% Vs 66.8%, p = < 0.001) for irrigation users and irrigation nonusers, respectively. Family labor, TLU, cultivated land size, training, access to irrigation, and participation in Off-farm activities were positively associated with household food security. While the age of household head and dependency ratio negatively affected household food security.
Remediation of pear iron chlorosis by nanocellulose-iron chelation and mechanisms
Authors: Wang Hezhong 
Published: September 2021

Abstract
Background: Nanocrystal cellulose has a strong ability to chelate iron and the nanocomposite possesses strong adsorptive property. Iron deficiency chlorosis (IDC) is a mineral disorder that weakens pear photosynthesis and cause a significant decline in plant yield and quality. Conventional methods to control IDC are generally due to low efficiency and overuse of chemicals. The purpose of this study was to explore the capability of nanocellulose (NC)-Fe chelate to remediate pear IDC. Acidic hydrolyzed NCs were chelated with Fe (NCFe) based on the net charge density of the components. Foliar application of NCFe was employed to pre-etiolated seedlings of Pyrus betulifolia as a plant material. The ability of NCFe to promote active iron content (CFe), photosynthesis rate, and relative gene expression was studied. Results: Nanocrystal cellulose prepared by acidic hydrolysis exhibit rod-like whiskers carrying on negative charges. When NCs were mixed with FeSO4, the NCFe particles maintained a small, whisker-like morphology with small dots (Fe) on the surface of the NC particles. The Z-average hydrodynamic diameter and zeta potential of the NC whiskers measured by DLS were 84.3 ± 0.2 nm and -47.3 ± 1.7 mV, respectively. The particle size and zeta potential of NCFe were 107.4±3.0 nm and -9.7±0.4 mV, respectively. The results showed that NCFe could significantly mitigate IDC in seedlings by increasing CFe, photosynthesis parameters, major physiological indicators, and regulating the expression of key enzymes. When NCFe was prepared at a NC-to-Fe charge density ratio of 1:3,000, CFe and chlorophyll contents were enhanced by approximately 9 times and 72.7%, respectively; the major physiological indicators were all significantly increased. Interestingly, NCFe treatment significantly downregulated the expression of the pectin methylesterase gene (PbPME) and upregulated the expression of the ferritin gene (PbFER) to increase CFe.Conclusion: NCs have strong potential to promote plant photosynthesis when chelated with Fe. The remediation capability of NCFe to IDC is attributed to the enhancement of photosynthesis parameters and indicators. NCFe treatment significantly downregulated the expression of the PME gene (PbPME) and upregulated the expression of the ferritin gene (PbFER) to increase the active iron content. This finding will provide a good alternative and a complementary strategy for Fe-chelate applications in plant iron chlorosis management.