bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward Critical State Studies: Bringing the Democratic State Back into American Literary Criticism
Authors: Roudeau Cécile 
Published: October 2021

Abstract
This essay starts from the apparent disconnect between democracy and the State in American literary studies. Taking the case of antebellum US literature (James Fenimore Cooper and Lydia Maria Child), it contends that literature is one place of elaboration of a democratic statecraft. Nineteenth-century US literature has been read as both complicit with and resisting to reigning models of statecraft endorsing racial domination, bureaucratization, and the monopoly of violence. However, we remain indifferent at our own peril to the potential forces of State as a democratic public authority and of state regulation as a non-arbitrary public provision. Putting American literature to the test of statecraft and statecraft to the test of literature, critical State studies proposes to revisit literary practices as a mode of critique in nineteenth-century state building. Nineteenth-century literature, I argue, both facilitated and performed this critique. Reading nineteenth-century US literature from the perspective of critical State studies—here, reading The American Frugal Housewife as a manual of democratic regulatory practice, or The Pioneers as an attempt at democratic environmental governance—allows us to investigate how literature, as a mode of representation and a political practice, gives shape and voice to alternative modes of statecraft.
Turning the State into a methodological problem, a pressure point of generative possibilities, critical State Studies requires that we attend to an alternative genealogy of the State and recover a past that has not yet been present in our reading of American literature.
Assessment of the Light Exposures of Shift-working Nurses in London and Dortmund in Relation to Recommendations for Sleep and Circadian Health
Authors: Price Luke L A , Khazova Marina , Udovičić Ljiljana 
Published: October 2021

AbstractShift work causes disruption to circadian physiological processes in the human body, and desynchronization from the natural day-and-night rhythm. Circadian disruption is thought to explain the associations between shift work and various long-term diseases; light is an unrivalled synchronizer (or Zeitgeber) of circadian processes and inappropriate light exposure plausibly plays a critical role in the development of health impairments. As published measurement data on the actual light environments encountered by shift workers are sparse, nurses working in two hospitals in London (UK) and Dortmund (Germany) wore light-logging dosimetry devices to measure personal light exposures continuously over a week in three different seasons. The study identifies and quantifies several of the characteristics of light exposure related to different working patterns in winter, spring, and summer, and quantifies interindividual variations. These data enable informed design of light exposure interventions or changes to shifts to reduce unwanted effects of disruptive light exposure profiles.
The environmental adaptation strategy of seed germination, and roles of the seed pappus on dispersal and hypocotyl hairs on seedling anchorage inTamarix ramosissima
Authors: Li Caixia , Wei Xiaowei , Lan Haiyan 
Published: October 2021

AbstractSeed dispersal, germination and seedling establishment are affected by various ecological factors in desert plant species. Tamarix ramosissima has evolved multiple strategies to facilitate its survival in harsh environments during the early stages of development. In this study, we investigated the effects of different ecological factors on seed germination and seedling growth, the function of the seed pappus in seed dispersal, as well as the function of the hypocotyl hairs in seedling establishment. We found that the seed germination of T. ramosissima was rapid and could occur under a wide range of temperatures (5–30 °C), after long periods of storage (at least 12 months on dispersal), under high concentrations of salts (700–900 mmol·L−1) and polyethylene glycol (PEG) 6000 (500 g·L−1) and under medium concentrations of alkalis (300–500 mmol·L−1). Lower concentrations of salts and PEG promoted seedling growth. The seed pappus had no effect on seed germination, but it might function as an accessory structure that provides a buoyancy force and promotes long-distance seed dispersal. The hypocotyl hairs located on the edge of the hypocotyl end might aid the upright positioning of the seedlings during early development, especially when seed germination occurs under floating or flooding conditions. In conclusion, the germination of T. ramosissima seeds and seedling development can occur under diverse types of abiotic stress, and the seed pappus and hypocotyl hairs played an important role in seed dispersal and seedling establishment.
A roadmap for multi-omics data integration using deep learning
Authors: Kang Mingon , Ko Euiseong , Mersha Tesfaye B 
Published: October 2021

AbstractHigh-throughput next-generation sequencing now makes it possible to generate a vast amount of multi-omics data for various applications. These data have revolutionized biomedical research by providing a more comprehensive understanding of the biological systems and molecular mechanisms of disease development. Recently, deep learning (DL) algorithms have become one of the most promising methods in multi-omics data analysis, due to their predictive performance and capability of capturing nonlinear and hierarchical features. While integrating and translating multi-omics data into useful functional insights remain the biggest bottleneck, there is a clear trend towards incorporating multi-omics analysis in biomedical research to help explain the complex relationships between molecular layers. Multi-omics data have a role to improve prevention, early detection and prediction; monitor progression; interpret patterns and endotyping; and design personalized treatments. In this review, we outline a roadmap of multi-omics integration using DL and offer a practical perspective into the advantages, challenges and barriers to the implementation of DL in multi-omics data.
New strategies to improve minimap2 alignment accuracy
Authors: Li Heng 
Published: October 2021

Abstract

Summary
We present several recent improvements to minimap2, a versatile pairwise aligner for nucleotide sequences. Now minimap2 v2.22 can more accurately map long reads to highly repetitive regions and align through insertions or deletions up to 100 kb by default, addressing major weakness in minimap2 v2.18 or earlier.

Availability and implementation
https://github.com/lh3/minimap2.
Nobiletin-induced partial abrogation of deleterious effects of AKT inhibition on preimplantation bovine embryo development in vitro†
Authors: Cajas Yulia N , Cañón-Beltrán Karina , Núñez-Puente Carolina , Gutierrez-Adán Alfonso , González Encina M , Agirregoitia Ekaitz , Rizos Dimitrios 
Published: October 2021

Abstract
During preimplantational embryo development, PI3K/AKT regulates cell proliferation and differentiation and nobiletin modulates this pathway to promote cell survival. Therefore, we aimed to establish whether, when the AKT cascade is inhibited using inhibitors III and IV, nobiletin supplementation to in vitro culture media during the minor (2- to 8-cell stage, MNEGA) or major (8- to 16-cell stage, MJEGA) phases of EGA is able to modulate the development and quality of bovine embryos. In vitro zygotes were cultured during MNEGA or MJEGA phase in SOF + 5% FCS or supplemented with: 15 μM AKT-InhIII; 10 μM AKT-InhIV; 10 μM nobiletin; nobiletin + AKT-InhIII; nobiletin + AKT-InhIV; 0.03% DMSO. Embryo development was lower in treatments with AKT inhibitors, while combination of nobiletin with AKT inhibitors was able to recover their adverse developmental effect and also increase blastocyst cell number. The mRNA abundance of GPX1, NFE2L2, and POU5F1 was partially increased in 8- and 16-cell embryos from nobiletin with AKT inhibitors. Besides, nobiletin increased the p-rpS6 level whether or not AKT inhibitors were present. In conclusion, nobiletin promotes bovine embryo development and quality and partially recovers the adverse developmental effect of AKT inhibitors, which infers that nobiletin probably uses another signaling cascade that PI3K/AKT during early embryo development in bovine.
Linking immune-mediated damage to neurodegeneration in multiple sclerosis: could network-based MRI help?
Authors: Groppa Sergiu , Gonzalez-Escamilla Gabriel , Eshaghi Arman , Meuth Sven G , Ciccarelli Olga 
Published: October 2021

Abstract
Inflammatory demyelination characterizes the initial stages of multiple sclerosis, while progressive axonal and neuronal loss are coexisting and significantly contribute to the long-term physical and cognitive impairment. There is an unmet need for a conceptual shift from a dualistic view of multiple sclerosis pathology, involving either inflammatory demyelination or neurodegeneration, to integrative dynamic models of brain reorganization, where, glia-neuron interactions, synaptic alterations and grey matter pathology are longitudinally envisaged at the whole-brain level. Functional and structural MRI can delineate network hallmarks for relapses, remissions or disease progression, which can be linked to the pathophysiology behind inflammatory attacks, repair and neurodegeneration. Here, we aim to unify recent findings of grey matter circuits dynamics in multiple sclerosis within the framework of molecular and pathophysiological hallmarks combined with disease-related network reorganization, while highlighting advances from animal models (in vivo and ex vivo) and human clinical data (imaging and histological). We propose that MRI-based brain networks characterization is essential for better delineating ongoing pathology and elaboration of particular mechanisms that may serve for accurate modelling and prediction of disease courses throughout disease stages.
Dose-dependent immunomodulatory effects of bortezomib in experimental autoimmune neuritis
Authors: Klimas Rafael , Sgodzai Melissa , Motte Jeremias , Mohamad Nuwin , Renk Pia , Blusch Alina , Grüter Thomas , Pedreiturria Xiomara , Gobrecht Philipp , Fischer Dietmar , Schneider-Gold Christiane , Reinacher-Schick Anke , Tannapfel Andrea , Yoon Min-Suk , Gold Ralf , Pitarokoili Kalliopi 
Published: October 2021

Abstract
Proteasome inhibition with bortezomib has been reported to exert an immunomodulatory action in chronic autoimmune neuropathies. However, bortezomib used for the treatment of multiple myeloma induces a painful toxic polyneuropathy at a higher concentration. Therefore, we addressed this controversial effect and evaluated the neurotoxic and immunomodulatory mode of action of bortezomib in experimental autoimmune neuritis. Bortezomib-induced neuropathy was investigated in Lewis rats using the von Frey hair test, electrophysiological, qPCR and histological analyses of the sciatic nerve as well as dorsal root ganglia outgrowth studies. The immunomodulatory potential of bortezomib was characterized in Lewis rats after experimental autoimmune neuritis induction with P253-78 peptide. Clinical, electrophysiological, histological evaluation, von Frey hair test, flow cytometric and mRNA analyses were used to unravel the underlying mechanisms. We defined the toxic concentration of 0.2 mg/kg bortezomib applied intraperitoneally at Days 0, 4, 8 and 12. This dosage induces a painful toxic neuropathy but preserves axonal regeneration in vitro. Bortezomib at a concentration of 0.05 mg/kg significantly ameliorated experimental autoimmune neuritis symptoms, improved experimental autoimmune neuritis-induced hyperalgesia and nerve conduction studies, and reduced immune cell infiltration. Furthermore, proteasome inhibition induced a transcriptional downregulation of Nfkb in the sciatic nerve, while its inhibitor Ikba (also known as Nfkbia) was upregulated. Histological analyses of bone marrow tissue revealed a compensatory increase of CD138+ plasma cells. Our data suggest that low dose bortezomib (0.05 mg/kg intraperitoneally) has an immunomodulatory effect in the context of experimental autoimmune neuritis through proteasome inhibition and downregulation of nuclear factor 'kappa-light-chain-enhancer' of activated B-cells (NFKB). Higher bortezomib concentrations (0.2 mg/kg intraperitoneally) induce sensory neuropathy; however, the regeneration potential remains unaffected. Our data empathizes that bortezomib may serve as an attractive treatment option for inflammatory neuropathies in lower concentrations.
Investment risk evaluation of inland floating photovoltaic power plants in China using the HFLTS–TFN method
Authors: Xiao Yanli , Ju Xin , Yu Bo , Wang Zheng , Xu Chuanbo 
Published: October 2021

Abstract
Inland floating photovoltaic power plants (IFPPPs) are the key to making full use of water advantages to develop solar resources in the future. Identifying the investment risk is an important prerequisite for promoting the projects on a large scale. This paper proposes a model to assess the investment risk of IFPPPs in China. First, this paper identifies the investment risk factors and establishes an evaluation indicator system from four aspects. Second, the indicator data are collected and described by adopting hesitant fuzzy linguistic term sets and triangular fuzzy numbers to ensure soundness and completeness. Third, a weighted method combining the best–worst method and the entropy method are utilized to determine the indicator weights under the consideration of the impact of subjective preferences and objective fairness. Fourth, the results show that the overall risk level of China’s IFPPPs is ‘medium low’. Fifth, sensitivity analysis and comparative analysis are implemented to examine the stability of the evaluation results. Finally, this paper also provides some risk-response strategies for the development of China’s IFPPPs from economy, society, technology and environment.
Resistance to the Sugarcane Borer (Lepidoptera: Crambidae) in Louisiana Sugarcane Cultivars
Authors: Salgado Leonardo D , Wilson Blake E , Villegas James M , Richard Randy T , Penn Hannah J 
Published: October 2021

AbstractCultivar resistance is a key management strategy for the sugarcane borer, Diatraea saccharalis (F.), the primary pest in Louisiana sugarcane, but mechanisms of resistance are not well understood. This research evaluated the potential mechanisms of cultivar resistance to D. saccharalis among commercially produced sugarcane cultivars and experimental lines through three field screenings, two greenhouse experiments, and one diet incorporation assay. The resistant standards HoCP 85-845, HoCP 04-838, and L 01-299 were among the cultivars with the lowest D. saccharalis injury levels in both field and greenhouse trials. Cultivars HoCP 00-950 and L 12-201 were among the most heavily injured in both trials. Differences in oviposition among cultivars in the greenhouse choice study were not detected, suggesting adult preference is not a key factor in resistance. This was also supported by the no-choice greenhouse experiment in which up to 9-fold differences in neonate establishment among cultivars were detected. Larval injury among cultivars in greenhouse experiments was consistent with field studies suggesting traits that affect neonate establishment (e.g., rind hardness) help to confer resistance in the field. In the diet incorporation assay, lower larval weights and longer time to pupation were observed on resistant cultivar Ho 08-9003, but no differences were found among current commercial cultivars. Continuous evaluation of cultivar resistance to D. saccharalis is important in developing effective integrated pest management strategies for this pest. More research into plant characteristics (e.g., leaf sheath tightness and pubescence) associated with resistance is needed.
The impact of atrial fibrillation and stroke risk factors on left atrial blood flow characteristics
Authors: Spartera Marco , Stracquadanio Antonio , Pessoa-Amorim Guilherme , Von Ende Adam , Fletcher Alison , Manley Peter , Ferreira Vanessa M , Hess Aaron T , Hopewell Jemma C , Neubauer Stefan , Wijesurendra Rohan S , Casadei Barbara 
Published: October 2021

Abstract

Aims
Altered left atrial (LA) blood flow characteristics account for an increase in cardioembolic stroke risk in atrial fibrillation (AF). Here, we aimed to assess whether exposure to stroke risk factors is sufficient to alter LA blood flow even in the presence of sinus rhythm (SR).

Methods and results
We investigated 95 individuals: 37 patients with persistent AF, who were studied before and after cardioversion [Group 1; median CHA2DS2-VASc = 2.0 (1.5–3.5)]; 35 individuals with no history of AF but similar stroke risk to Group 1 [Group 2; median CHA2DS2-VASc = 3.0 (2.0–4.0)]; and 23 low-risk individuals in SR [Group 3; median CHA2DS2-VASc = 0.0 (0.0–0.0)]. Cardiac function and LA flow characteristics were evaluated using cardiac magnetic resonance. Before cardioversion, Group 1 displayed impaired left ventricular (LV) and LA function, reduced LA flow velocities and vorticity, and a higher normalized vortex volume (all P &lt; 0.001 vs. Groups 2 and 3). After restoration of SR at ≥4-week post-cardioversion, LV systolic function and LA flow parameters improved significantly (all P &lt; 0.001 vs. pre-cardioversion) and were no longer different from those in Group 2. However, in the presence of SR, LA flow peak and mean velocity, and vorticity were lower in Groups 1 and 2 vs. Group 3 (all P &lt; 0.01), and were associated with impaired LA emptying fraction (LAEF) and LV diastolic dysfunction.

Conclusion
Patients at moderate-to-high stroke risk display altered LA flow characteristics in SR in association with an LA myopathic phenotype and LV diastolic dysfunction, regardless of a history of AF.
Interleukin-1 blockade with anakinra and heart failure following ST-segment elevation myocardial infarction: results from a pooled analysis of the VCUART clinical trials
Authors: Abbate Antonio , Wohlford George F , Del Buono Marco Giuseppe , Chiabrando Juan Guido , Markley Roshanak , Turlington Jeremy , Kadariya Dinesh , Trankle Cory R , Biondi-Zoccai Giuseppe , Lipinski Michael J , Van Tassell Benjamin W 
Published: October 2021

Abstract

Aims
ST-segment elevation myocardial infarction (STEMI) is associated with an intense acute inflammatory response and an increased risk of death and heart failure (HF). In this study, we sought to evaluate the effect of anakinra, a recombinant interleukin-1 receptor antagonist, on the incidence of HF.

Methods and results
We performed a pooled analysis of three early phase randomized clinical trials. The endpoints included the composite of all-cause death and new-onset HF, and the composite of all-cause death and hospitalization for HF at 1-year follow-up. Safety events, including injection site reaction and serious infections, were also recorded. We analysed 139 patients with STEMI from three separate trials: VCUART (N = 10), VCUART2 (N = 30), and VCUART3 (N = 99). Of these, 84 (60%) patients were randomized to anakinra and 55 (40%) to placebo. Treatment with anakinra significantly reduced the incidence of all-cause death or new-onset HF (7 [8.2%] vs. 16 [29.1%], log-rank P = 0.002) and of all-cause death or HF hospitalization (0 [0] vs. 5 [9.1%], log-rank P = 0.007). Patients treated with anakinra had significantly higher injection site reactions (19 [22.6%] vs. 3 [5.5%], P = 0.016) without a significant difference in the incidence of serious infections (11 [13.1%] vs. 7 [12.7%], P = 0.435). Treatment with anakinra significantly reduced the area under the curve for high-sensitivity C-reactive protein between baseline and 14 days (75.48 [41.7–147.47] vs. 222.82 [117.22–399.28] mg day/L, P &lt; 0.001).

Conclusion
IL-1 blockade with anakinra for 14 days in patients with STEMI reduces the incidence of new-onset HF or hospitalization for HF at 1 year following STEMI.
Virtual-assisted lung mapping in sublobar resection of small pulmonary nodules, long-term results
Authors: Yamaguchi Hirokazu , Sato Masaaki , Yamamoto Kazumichi , Ueda Keiko , Date Hiroshi , Chen-Yoshikawa Toyofumi , Yamada Yoshito , Tokuno Junko , Yanagiya Masahiro , Kojima Fumitsugu , Yoshiyasu Nobuyuki , Kobayashi Masashi , Nakashima Yasuhiro , Koike Terumoto , Sakamoto Jin , Kosaka Shinji , Fukai Ryuta , Nishida Tomoki , Sakai Hiroaki , Shinohara Shinji , Takenaka Masaru , Tanaka Fumihiro , Misawa Kenji , Nakajima Jun 
Published: October 2021

Abstract

OBJECTIVES
The short-term efficacy of virtual-assisted lung mapping (VAL-MAP), a preoperative bronchoscopic multi-spot lung-marking technique, has been confirmed in 2 prospective multicentre studies. The objectives of this study were to analyse the local recurrence and survival of patients enrolled in these studies, long-term.

METHODS
Of the 663 patients enrolled in the 2 studies, 559 patients’ follow-up data were collected. After excluding those who did not undergo VAL-MAP, whose resection was not for curative intent, who underwent concurrent resection without VAL-MAP, or who eventually underwent lobectomy instead of sublobar resection (i.e. wedge resection or segmentectomy), 422 patients were further analysed.

RESULTS
Among 264 patients with primary lung cancer, the 5-year local recurrence-free rate was 98.4%, and the 5-year overall survival (OS) rate was 94.5%. Limited to stage IA2 or less (≤2 cm in diameter; n = 238, 90.1%), the 5-year local recurrence-free and OS rates were 98.7% and 94.8%, respectively. Among 102 patients with metastatic lung tumours, the 5-year local recurrence-free rate was 93.8% and the 5-year OS rate was 81.8%. Limited to the most common (colorectal) cancer (n = 53), the 5-year local recurrence-free and OS rates were 94.9% and 82.3%, respectively.

CONCLUSIONS
VAL-MAP, which is beneficial in localizing small barely palpable pulmonary lesions and determining the appropriate resection lines, was associated with reasonable long-term outcomes.

Subj collection
152, 1542
Focusing on ESOL teachers’ well-being during COVID-19 and beyond
Authors: Wong Chiu-Yin , Pompeo-Fargnoli Alyson , Harriott Wendy 
Published: October 2021

Abstract
The study reports the challenges that primary school ESOL teachers in the United States face because of the unexpected instructional changes during the COVID-19 pandemic and how these challenges appear to have affected the well-being of these teachers. Findings indicate that the participants’ stress levels increased due to the lack of support and compassion from school administrators, the lack of communication and connection with other teachers, increased workloads, teaching students with different levels of proficiency virtually, and a lack of technological devices for students. The newly emerged challenges have resulted in ESOL teachers reporting emotional and physical effects that did not exist before the pandemic. Based on the findings, we provide recommendations for school leaders and practical suggestions for ESOL teachers which can be applied during the pandemic and afterwards. We propose that ESOL teachers’ well-being should be on the agenda of school administration since teachers are on the frontlines of education.