bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel double-side welding approach for friction stir welding of polypropylene plate
Authors: Nath Rahul Kanti , Jha Vinayak , Maji Pabitra , Barma John Deb 
Published: January 2021

AbstractIn almost every industry, polymer materials are in high demand in recent years due to their lightweight and easy formability. However, eco-friendly, cost-efficient and defect-free joining of polymers is a major concern. In this article, a novel approach is taken for friction stir welding of polypropylene by implementing a double-side welding technique. The effect of tool rotational speed on construction and properties of the welded joints are studied. The torque and forces exerted on the tool during double-side welding are compared with single-side welding. Cross-sectional morphology examination using optical and scanning electron microscope reveals defect-free sound welding by double-side weld with uniform material flow. The molecular bonds of the welded specimens are examined by FTIR analysis. The double-side welding technique yields superior joints in terms of tensile strength and flexural strength than the joints obtained by single-side welding.
A randomized phase 1 single-dose polysomnography study of ASP8062, a GABAB receptor positive allosteric modulator
Authors: Walzer Mark , Wu Ruishan , Ahmad Maha , Freeman Jon , Zammit Gary , Marek Gerard J. 
Published: January 2021

Abstract
Rationale
Previous research suggests that sleep polysomnography and EEG endpoints can be used to assess GABAergic activity; however, the impact of GABAB receptor positive allosteric modulators on sleep endpoints remains unclear.

Objectives
This phase 1 study compared a single dose of ASP8062 (35 mg or 70 mg), a GABAB receptor positive allosteric modulator, with placebo and paroxetine (40 mg).

Methods
Healthy adult volunteers were randomized to four treatments (35 mg ASP8062, 70 mg ASP8062, paroxetine 40 mg, or matching placebo), each separated by a 14-day washout. Primary endpoints obtained by polysomnography were time in stage N3 or SWS and time in rapid eye movement (REM) sleep. Secondary endpoints included impact on sleep stages and electroencephalography parameters, pharmacokinetics, nighttime growth hormone (GH), and safety/tolerability.

Results
In 20 randomized volunteers, ASP8062 led to a significant and seemingly dose-dependent increase in SWS over the entire night; this increase was mainly observed during the first third of the night. ASP8062 did not impact time in REM sleep. Paroxetine had no effect on SWS but produced a significant reduction in time spent in REM sleep. A dose-dependent trend in increased GH release was also observed with ASP8062. Headache and nausea were the most commonly reported treatment-emergent adverse events (TEAEs) for ASP8062; most TEAEs were mild in severity.

Conclusions
Single-dose ASP8062 (35 and 70 mg) appeared to result in CNS penetration and enhanced GABAergic activity as measured by increases in slow-wave sleep and growth hormone release.
International recommendations for personalised selective internal radiation therapy of primary and metastatic liver diseases with yttrium-90 resin microspheres
Authors: Levillain Hugo , Bagni Oreste , Deroose Christophe M. , Dieudonné Arnaud , Gnesin Silvano , Grosser Oliver S. , Kappadath S. Cheenu , Kennedy Andrew , Kokabi Nima , Liu David M. , Madoff David C. , Mahvash Armeen , Martinez de la Cuesta Antonio , Ng David C. E. , Paprottka Philipp M. , Pettinato Cinzia , Rodríguez-Fraile Macarena , Salem Riad , Sangro Bruno , Strigari Lidia , Sze Daniel Y. , de Wit van der veen Berlinda J. , Flamen Patrick 
Published: January 2021

Abstract
Purpose
A multidisciplinary expert panel convened to formulate state-of-the-art recommendations for optimisation of selective internal radiation therapy (SIRT) with yttrium-90 (90Y)-resin microspheres.

Methods
A steering committee of 23 international experts representing all participating specialties formulated recommendations for SIRT with 90Y-resin microspheres activity prescription and post-treatment dosimetry, based on literature searches and the responses to a 61-question survey that was completed by 43 leading experts (including the steering committee members). The survey was validated by the steering committee and completed anonymously. In a face-to-face meeting, the results of the survey were presented and discussed. Recommendations were derived and level of agreement defined (strong agreement ≥ 80%, moderate agreement 50%–79%, no agreement ≤ 49%).

Results
Forty-seven recommendations were established, including guidance such as a multidisciplinary team should define treatment strategy and therapeutic intent (strong agreement); 3D imaging with CT and an angiography with cone-beam-CT, if available, and 99mTc-MAA SPECT/CT are recommended for extrahepatic/intrahepatic deposition assessment, treatment field definition and calculation of the 90Y-resin microspheres activity needed (moderate/strong agreement). A personalised approach, using dosimetry (partition model and/or voxel-based) is recommended for activity prescription, when either whole liver or selective, non-ablative or ablative SIRT is planned (strong agreement). A mean absorbed dose to non-tumoural liver of 40 Gy or less is considered safe (strong agreement). A minimum mean target-absorbed dose to tumour of 100–120 Gy is recommended for hepatocellular carcinoma, liver metastatic colorectal cancer and cholangiocarcinoma (moderate/strong agreement). Post-SIRT imaging for treatment verification with 90Y-PET/CT is recommended (strong agreement). Post-SIRT dosimetry is also recommended (strong agreement).

Conclusion
Practitioners are encouraged to work towards adoption of these recommendations.
AChRAb and MuSKAb double-seropositive myasthenia gravis: a distinct subtype?
Authors: Zhang Jieni , Chen Yin , Chen Jiaxin , Huang Xin , Wang Haiyan , Li Yan , Liu Weibin , Feng Huiyu 
Published: January 2021

Abstract
Introduction
This study investigated the characteristics of double-seropositive myasthenia gravis (DSP-MG) in southern China for disease subtype classification.

Methods
A case-control study was carried out in which the characteristics of DSP-MG patients (n = 17) were compared to those of muscle-specific tyrosine kinase antibody-positive (MuSK)-MG and acetylcholine receptor antibody-positive (AChR)-MG patients (n = 8 and 27, respectively). We also performed a literature review of DSP-MG patients.

Results
Compared to AChR-MG, DSP-MG had greater bulbar dysfunction (47.1% vs 18.6%, P = 0.04), higher incidence of myasthenia crisis (41.2% vs 14.8%, P = 0.04), more severe Myasthenia Gravis Foundation of America classification at maximum worsening, greater autoantibody abnormalities (70.6% vs 33.3%, P = 0.015), greater need for immunosuppressant treatment (58.8% vs 3.7%, P < 0.001), and worse prognosis with less remission (11.8% vs 55.6%, P = 0.001). There were no differences between DSP-MG and MuSK-MG patients. DSP-MG described in published reports was comparable to MuSK-MG.

Discussion
DSP-MG in southern China may be a subtype of MuSK-MG.
Applicability and performance of EUCAST’s rapid antimicrobial susceptibility testing (RAST) on primarily sterile body fluids in blood culture bottles in laboratory routine with total lab automation
Authors: Jasuja Jasmin Kaur , Zimmermann Stefan , Burckhardt Irene 
Published: January 2021

AbstractOptimisation of microbiological diagnostics in primarily sterile body fluids is required. Our objective was to apply EUCAST’s RAST on primarily sterile body fluids in blood culture bottles with total lab automation (TLA) and to compare results to our reference method Vitek2 in order to report susceptibility results earlier. Positive blood culture bottles (BACTEC™ Aerobic/Anaerobic/PEDS) inoculated with primarily sterile body fluids were semi-automatically subcultured onto Columbia 5% SB agar, chocolate agar, MacConkey agar, Schaedler/KV agar and Mueller-Hinton agar. On latter, cefoxitin, ampicillin, vancomycin, piperacillin/tazobactam, meropenem and ciprofloxacin were added. After 6 h, subcultures and RAST were imaged and MALDI-TOF MS was performed. Zone sizes were digitally measured and interpreted following RAST breakpoints for blood cultures. MIC values were determined using Vitek2 panels. During a 1-year period, 197 Staphylococcus aureus, 91 Enterococcus spp., 38 Escherichia coli, 11 Klebsiella pneumoniae and 8 Pseudomonas aeruginosa were found. Categorical agreement between RAST and MIC was 96.5%. Comparison showed no very major errors, 2/7 (28.6%) and 1/7 (14.3%) of major errors for P. aeruginosa and meropenem and ciprofloxacin, 1/9 (11.1%) for K. pneumoniae and ciprofloxacin, 4/69 (7.0%) and 3/43 (5.8%) for Enterococcus spp. and vancomycin and ampicillin, respectively. Minor errors for P. aeruginosa and meropenem (1/8; 12.8%) and for E. coli and ciprofloxacin (2/29; 6.5%) were found. 30/550 RAST measurements were within area of technical uncertainty. RAST is applicable and performs well for primarily sterile body fluids in blood culture bottles, partially better than blood-based RAST. Official EUCAST evaluation is needed.
Nocturnal singing by diurnal birds in Afrotropical highlands
Authors: Budka Michał , Skierczyńska Anna , Antczak Marcin , Osiejuk Tomasz S. 
Published: January 2021

AbstractMost bird species are active by day. However, even typically diurnal species have been observed to sing by night, although the functions and mechanisms of this behaviour are not well understood. In our study, we focused on nocturnal singing by diurnal birds in Afrotropical highlands (Bamenda Highlands, Cameroon). We recorded 48-h soundscapes in 18 random recording sites using autonomous sound recorders to examine the occurrence and intensity of nocturnal singing among diurnal birds. We applied three definitions of night—the time period between: (1) astronomical, (2) nautical and (3) civil dusk and dawn, which may include or exclude beginning of dawn chorus from the night-time period. We recorded 53 bird species, representing seven orders and 27 families. Of 50 typically diurnal species, only three sang by astronomical night, producing in total 10 songs. Applying the nautical night definition did not change the meaning of the results—the same three species produced 12 vocalisations. By civil night, 21 species were recorded singing. From the analysed 2128 vocalisations produced by civil night, 2109 were produced during 25 min period between nautical and civil dawn (22–47 min before sunrise), what suggests that civil night covers the beginning of dawn chorus and should not be considered as a nighttime. Our study reveals that in Afrotropical highlands, unlike in temperate regions, diurnal birds stay silent at night. Using astronomical and nautical definition of night gives similar results. The intensive singing recorded between nautical and civil dawn (included into nautical night), we interpreted as the beginning of dawn chorus rather than true night singing. We suggest that precise definition of nighttime is required to compare the results of different studies and to better understand the phenomenon of night singing by diurnal birds.
Growth hormone transgenesis and feed composition influence growth and protein and amino acid content in transgenic G3 mutiara catfish (Clarias gariepinus)
Authors: Buwono Ibnu Dwi , Iskandar Iskandar , Grandiosa Roffi 
Published: January 2021

AbstractClarias gariepinus growth hormone (CgGH) transgenesis was previously used to develop a population of second-generation (G2) transgenic mutiara catfish (C. gariepinus). The third generation of these fish (1-month old fingerlings) had 2–3 times improvement in growth compared to non-transgenic fish in the commercial feed test for 6 weeks of rearing. We assessed the impact of CgGH transgene expression on growth and protein and amino acid content of the G3 generation of these transgenic mutiara catfish relative to non-transgenic catfish. Since variation in composition of feed mixes can affect protein and amino acid content of fish, we tested three mixtures of commercial feed and boiled tuna (Euthynnus affinis): feed A (50:50 feed to tuna), B (65:35), and C (80:20) to transgenic catfish. Feed A* (50:50) was fed as a control to non-transgenic catfish. Feed efficiency, including feed conversion ratio and protein use efficiency (i.e., protein retention and protein productive value), was assessed. Feed efficiency, protein content, and essential amino acid content in G3 transgenic catfish (feed A and B) were higher than in non-transgenic fish (feed A*). The latter were deficient in lysine and methionine. Transgenic catfish fed with feed C (80:20) showed lysine deficiency and lower growth than fish fed feeds A and B. Feed B (65:35) was the optimal feed mixture utilized; it increased growth, protein levels, and feed conversion efficiency in G3 catfish. The growth of transgenic fish was higher than non-transgenic fish when supported by feeding with balanced nutrients.
Homework and Children in Grades 3–6: Purpose, Policy and Non-Academic Impact
Authors: Holland Melissa , Courtney McKenzie , Vergara James , McIntyre Danielle , Nix Samantha , Marion Allison , Shergill Gagan 
Published: January 2021

Abstract
Background
Increasing academic demands, including larger amounts of assigned homework, is correlated with various challenges for children. While homework stress in middle and high school has been studied, research evidence is scant concerning the effects of homework on elementary-aged children.

Objective
The objective of this study was to understand rater perception of the purpose of homework, the existence of homework policy, and the relationship, if any, between homework and the emotional health, sleep habits, and parent–child relationships for children in grades 3–6.

Method
Survey research was conducted in the schools examining student (n = 397), parent (n = 442), and teacher (n = 28) perception of homework, including purpose, existing policy, and the childrens’ social and emotional well-being.

Results
Preliminary findings from teacher, parent, and student surveys suggest the presence of modest impact of homework in the area of emotional health (namely, student report of boredom and frustration), parent–child relationships (with over 25% of the parent and child samples reporting homework always or often interferes with family time and creates a power struggle), and sleep (36.8% of the children surveyed reported they sometimes get less sleep) in grades 3–6. Additionally, findings suggest misperceptions surrounding the existence of homework policies among parents and teachers, the reasons teachers cite assigning homework, and a disconnect between child-reported and teacher reported emotional impact of homework.

Conclusions
Preliminary findings suggest homework modestly impacts child well-being in various domains in grades 3–6, including sleep, emotional health, and parent/child relationships. School districts, educators, and parents must continue to advocate for evidence-based homework policies that support children’s overall well-being.
Emotional and Behavioral Trajectories of 2 to 9 Years Old Children Born to Opioid-Dependent Mothers
Authors: Jaekel Julia , Kim Hyun M. , Lee Samantha J. , Schwartz Ashlyn , Henderson Jacqueline M. T. , Woodward Lianne J. 
Published: January 2021

AbstractMaternal opioid use in pregnancy has increased dramatically. Knowledge about children’s longer-term emotional and behavioral development after prenatal opioid exposure is scarce. A regional sample of 89 opioid-exposed and 104 non-exposed comparison children were studied prospectively at ages 2, 4.5, and 9 years using the Strengths and Difficulties Questionnaire (SDQ) completed by primary caregivers. Across all childhood assessments, opioid-exposed children obtained significantly higher total difficulties scores than non-exposed comparison children. Growth curve modeling revealed that, relative to their same age peers, opioid-exposed children’s emotional and behavioral difficulties significantly worsened over time. Moreover, fixed effects estimates showed that total difficulties trajectories were poorer for children subject to higher prenatal risk (Est = 1.78, 95% CI = [0.46, 3.09]) who were born to mothers with high levels of social adversity (1.11 [0.51, 1.71]), and were then raised in families characterized by high levels of psychosocial risk (1.94 [0.90, 2.98]) and unstable caregiving (1.91 [0.33, 3.48]). A complex set of pre- and postnatal processes contribute to opioid-exposed children’s emotional and behavioral development. Efforts to mitigate the long-term consequences of opioid use in pregnancy need to consider both children’s and their caregivers’ biopsychosocial risks.
Latency Reversal 2.0: Giving the Immune System a Seat at the Table
Authors: Singh Vidisha , Dashti Amir , Mavigner Maud , Chahroudi Ann 
Published: January 2021

Abstract
Purpose of Review
For most people living with HIV (PLWH), treatment with effective antiretroviral therapy (ART) results in suppression of viremia below the limit of detection of clinical assays, immune reconstitution, reduced immune activation, avoidance of opportunistic infections, and progression to AIDS. However, ART alone is not curative, and HIV persists in a non-replicating, latent form. In this review, we provide a historical perspective on non-specific latency reversal approaches (LRA 1.0) and summarize recent advances in latency reversal strategies that target specific signaling pathways within CD4+ T cells or other immune cells to induce expression of latent HIV (immune-based latency reversal, or LRA 2.0).

Recent Findings
The HIV reservoir is primarily composed of latently infected CD4+ T cells carrying integrated, replication-competent provirus that can give rise to rebound viremia if ART is stopped. Myeloid lineage cells also contribute to HIV latency in certain tissues; we focus here on CD4+ T cells as a sufficient body of evidence regarding latency reversal in myeloid cells is lacking. The immunomodulatory LRA 2.0 approaches we describe include pattern recognition receptor agonists, immune checkpoint inhibitors, non-canonical NF-kB stimulation, and transient CD8+ lymphocyte depletion, along with promising combination strategies. We highlight recent studies demonstrating robust latency reversal in nonhuman primate models.

Summary
While significant strides have been made in terms of virus reactivation from latency, initial hopes for latency reversal alone to result in a reduction of infected cells, through viral cytopathic effect or an unboosted immune system, have not been realized and it seems clear that even effective latency reversal strategies will need to be paired with an approach that facilitates immune recognition and clearance of cells containing reactivated virus.
Investigating hesperetin nanocrystals with tailor-made sizes for the prevention and treatment of Alzheimer’s disease
Authors: Stahr Pascal-L. , Grewal Rekha , Eckert Gunter P. , Keck Cornelia M. 
Published: January 2021

Abstract
Poor aqueous solubility of drug substances is associated with poor bioavailability and thus hampers the effective use of many potent active pharmaceutical ingredients. Various strategies to overcome poor solubility are available, whereby drug nanocrystals represent one of the most powerful formulation strategies to enhance the kinetic solubility and dissolution rate of poorly soluble drugs. Nanocrystals are simply obtained by milling large-sized drug powders to sizes < 1 µm. The so obtained nanocrystals possess an increased dissolution rate and kinetic solubility when compared with larger-sized bulk material. The aim of this study was to produce differently sized hesperetin nanocrystals and to investigate the influence of nanocrystal size on the bioefficacy of the natural antioxidant hesperetin in two cell culture models for the prevention and treatment of Alzheimer’s disease. Results showed that the testing of poorly soluble compounds is challenging and requires incredibly careful characterization. Reasons for this are possible changes of the formulations in cell culture media which can occur due to various reasons. If the changes are not considered, results obtained can be misleading and even lead to a false interpretation of the results obtained. Besides, results demonstrate the increase in dissolution rate with decreasing particle size that is especially pronounced with particle sizes < 200 nm. Data also provide clear evidence that smaller nanocrystals with higher kinetic solubility possess higher antioxidant capacity. This results in lower amounts of free radicals in the cell culture models, suggesting that hesperetin nanocrystals, that improve the poor aqueous solubility of hesperetin, are promising for the prevention and treatment of Alzheimer’s disease.

Graphical abstract
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Dependence of the Generation Behavior of Charged Nanoparticles and Ag Film Growth on Sputtering Power during DC Magnetron Sputtering
Authors: Jang Gil Su , Kim Du Yun , Hwang Nong-Moon 
Published: January 2021

Abstract
Effects of sputtering power on the deposition rate and microstructure, crystallinity, and electrical properties of Ag films during direct current (DC) magnetron sputtering are investigated. Thin films (~ 100 nm) are deposited at sputtering powers of 10, 20, 50, 100, 200 and 300 W and analyzed by field-emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), transmission electron microscopy (TEM) and a four-point probe. The film deposited at a sputtering power of 10 W has the lowest growth rate, but the highest crystalline quality, with the lowest full width at half maximum (FWHM) and the lowest resistivity. The film deposited at a sputtering power of 200 W has the highest growth rate, and the second best crystalline quality in view of FWHM and resistivity. The film deposited at a sputtering power of 50 W has the moderate growth rate, and the worst crystalline quality in view of FWHM and resistivity. High-resolution TEM observations reveal that films deposited at sputtering powers of 10 and 200 W have far fewer defects, such as grain boundaries, dislocations and stacking faults than those deposited at a sputtering power of 50 W. Such deposition behavior could be explained by sputtering power, which affected the generation of the charged nanoparticles. And the high quality of films could be obtained at a high deposition rate, in which charge plays an important role.

Graphic Abstract
A Review on Metal–Organic Framework-Derived Porous Carbon-Based Novel Microwave Absorption Materials
Authors: Zhang Zhiwei , Cai Zhihao , Wang Ziyuan , Peng Yaling , Xia Lun , Ma Suping , Yin Zhanzhao , Huang Yi 
Published: January 2021

AbstractThe development of microwave absorption materials (MAMs) is a considerable important topic because our living space is crowed with electromagnetic wave which threatens human’s health. And MAMs are also used in radar stealth for protecting the weapons from being detected. Many nanomaterials were studied as MAMs, but not all of them have the satisfactory performance. Recently, metal–organic frameworks (MOFs) have attracted tremendous attention owing to their tunable chemical structures, diverse properties, large specific surface area and uniform pore distribution. MOF can transform to porous carbon (PC) which is decorated with metal species at appropriate pyrolysis temperature. However, the loss mechanism of pure MOF-derived PC is often relatively simple. In order to further improve the MA performance, the MOFs coupled with other loss materials are a widely studied method. In this review, we summarize the theories of MA, the progress of different MOF-derived PC‑based MAMs, tunable chemical structures incorporated with dielectric loss or magnetic loss materials. The different MA performance and mechanisms are discussed in detail. Finally, the shortcomings, challenges and perspectives of MOF-derived PC‑based MAMs are also presented. We hope this review could provide a new insight to design and fabricate MOF-derived PC-based MAMs with better fundamental understanding and practical application.