bluuebunny/crossref_metadata_2025_split huggingface dataset:
The making of a conservation landscape: the emergence of a conservationist environmental infrastructure along the Kwando River in Namibia's Zambezi region
Authors: Bollig Michael , Vehrs Hauke-Peter 
Published: March 2021

AbstractThe Kwando Basin of north-eastern Namibia is firmly embedded in current national and international conservation agendas. It is a key part of the world's largest transboundary conservation area, the Kavango–Zambezi (KAZA) Transfrontier Conservation Area, and the home of seven community-based conservation areas (conservancies) and three smaller national parks (Mudumu, Nkasa Rupara and Bwabwata). While conservation agendas often start from the assumption that an authentic part of African nature is conserved as an assemblage of biota that has not been gravely impacted by subsistence agriculture, colonialism and global value chains, we show that environmental infrastructure along the Namibian side of the Kwando Valley has been shaped by the impact of administrative measures and the gradual decoupling of humans and wildlife in a vast wetland. The way towards today's conservation landscape was marked and marred by the enforced reordering of human–environment relations; clearing the riverine core wetlands of human habitation and concentrating communities in narrowly defined settlement zones; the suppression of specific, wetland-adapted subsistence practices; and the elimination of unwanted microbes with the help of insecticides. The interventions in the ecosystem and the construction of an environmental infrastructure have created a unique conservation landscape in the Namibian Zambezi region, which provides the foundation for its popularity and success.
Made in China, fashioned in Africa: ethnic dress in Ethiopia and Mozambique
Authors: von Pezold Johanna , Driessen Miriam 
Published: March 2021

AbstractThe influx of Chinese-made African ethnic dress has been central to debates about the consequences of the growing Chinese presence in Africa. Exploring the reception of the Chinese-producedcapulanain Mozambique andnet'elain Ethiopia, we demonstrate that Mozambican and Ethiopian manufacturers and traders, from the grass roots up to cultural elites, engage with Chinese imports with creativity and verve. While welcoming Chinese materials for their affordability, bold and bright colours and suitability for dressmaking, they fashion them in ways that fit their own tastes and the local fashion trends. We distinguish three practices by which people do this: first, by incorporating Chinese materials or design elements into their own products; second, by co-creating new designs and dress with their Chinese counterparts; and third, by altering the imported fabrics. Apart from fashioning imports, some manufacturers use strategies to distinguish their own products from Chinese counterparts. These strategies include naming practices linked to the stories of their origin and alterations to the material.
Kant and the Demands of Normativity: Response to Harbin
Authors: Dunn Nicholas 
Published: March 2021

ABSTRACTI argue against Harbin's claim that aesthetic judgements, for Kant, are not normative. By focusing on the systematic nature of Kant's Critical philosophy, I show that aesthetic judgements, like judgements in the theoretical and practical domains, must be normative, though such judgements display a distinct kind of normativity, which is expressed in their subjectivity, indeterminacy, and affectivity.
MASS-FIX for the detection of monoclonal proteins and light chain N-glycosylation in routine clinical practice: a cross-sectional study of 6315 patients
Authors: Mellors Patrick W. , Dasari Surendra , Kohlhagen Mindy C. , Kourelis Taxiarchis , Go Ronald S. , Muchtar Eli , Gertz Morie A. , Kumar Shaji K. , Buadi Francis. K. , Willrich Maria A. V. , Lust John A. , Kapoor Prashant , Lacy Martha Q. , Dingli David , Hwa Yi , Fonder Amie , Hobbs Miriam , Hayman Susan , Warsame Rahma , Leung Nelson R. , Lin Yi , Gonsalves Wilson , Siddiqui Mustaqeem , Kyle Robert A. , Rajkumar S. Vincent , Murray David L. , Dispenzieri Angela 
Published: March 2021

AbstractImmunoenrichment-based matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS), termed MASS-FIX, offers several advantages over immunofixation for the detection and isotyping of serum monoclonal protein, including superior sensitivity and specificity, the ability to differentiate therapeutic monoclonal antibodies, and the rapid identification of light chain (LC) N-glycosylation. We identified 6315 patients with MASS-FIX performed at our institution since 2018. Of these, 4118 patients (65%) with a wide array of plasma cell disorders (PCD), including rare monoclonal gammopathies of clinical significance, had a positive MASS-FIX. Two-hundred twenty-one (5%) of the MASS-FIX positive patients had evidence of LC N-glycosylation, which was more commonly identified in IgM heavy chain isotype, kappa LC isotype, and in diagnoses of immunoglobulin light chain (AL) amyloidosis and cold agglutinin disease (CAD) compared to other PCD. This cross-sectional study describes the largest cohort of patients to undergo MASS-FIX in routine clinical practice. Our findings demonstrate the widespread utility of this assay, and confirm that LC N-glycosylation should prompt suspicion for AL amyloidosis and CAD in the appropriate clinical context.
Mesenchymal stem cells alleviate experimental immune-mediated liver injury via chitinase 3-like protein 1-mediated T cell suppression
Authors: Liu Qiuli , Chen Xiaoyong , Liu Chang , Pan Lijie , Kang Xinmei , Li Yanli , Du Cong , Dong Shuai , Xiang Andy Peng , Xu Yan , Zhang Qi 
Published: March 2021

AbstractLiver diseases with different pathogenesis share common pathways of immune-mediated injury. Chitinase-3-like protein 1 (CHI3L1) was induced in both acute and chronic liver injuries, and recent studies reported that it possesses an immunosuppressive ability. CHI3L1 was also expressed in mesenchymal stem cells (MSCs), thus we investigates the role of CHI3L1 in MSC-based therapy for immune-mediated liver injury here. We found that CHI3L1 was highly expressed in human umbilical cord MSCs (hUC-MSCs). Downregulating CHI3L1 mitigated the ability of hUC-MSCs to inhibit T cell activation, proliferation and inflammatory cytokine secretion in vitro. Using Concanavalin A (Con A)-induced liver injury mouse model, we found that silencing CHI3L1 significantly abrogated the hUC-MSCs-mediated alleviation of liver injury, accompanying by weakened suppressive effects on infiltration and activation of hepatic T cells, and secretion of pro-inflammatory cytokines. In addition, recombinant CHI3L1 (rCHI3L1) administration inhibited the proliferation and function of activated T cells, and alleviated the Con A-induced liver injury in mice. Mechanistically, gene set enrichment analysis showed that JAK/STAT signalling pathway was one of the most significantly enriched gene pathways in T cells co-cultured with hUC-MSCs with CHI3L1 knockdown, and further study revealed that CHI3L1 secreted by hUC-MSCs inhibited the STAT1/3 signalling in T cells by upregulating peroxisome proliferator-activated receptor δ (PPARδ). Collectively, our data showed that CHI3L1 was a novel MSC-secreted immunosuppressive factor and provided new insights into therapeutic treatment of immune-mediated liver injury.
Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis
Authors: Hutchinson James A. , Kronenberg Katharina , Riquelme Paloma , Wenzel Jürgen J. , Glehr Gunther , Schilling Hannah-Lou , Zeman Florian , Evert Katja , Schmiedel Martin , Mickler Marion , Drexler Konstantin , Bitterer Florian , Cordero Laura , Beyer Lukas , Bach Christian , Koestler Josef , Burkhardt Ralph , Schlitt Hans J. , Hellwig Dirk , Werner Jens M. , Spang Rainer , Schmidt Barbara , Geissler Edward K. , Haferkamp Sebastian 
Published: March 2021

AbstractTreatment of advanced melanoma with combined PD-1/CTLA-4 blockade commonly causes serious immune-mediated complications. Here, we identify a subset of patients predisposed to immune checkpoint blockade-related hepatitis who are distinguished by chronic expansion of effector memory CD4+ T cells (TEM cells). Pre-therapy CD4+ TEM cell expansion occurs primarily during autumn or winter in patients with metastatic disease and high cytomegalovirus (CMV)-specific serum antibody titres. These clinical features implicate metastasis-dependent, compartmentalised CMV reactivation as the cause of CD4+ TEM expansion. Pre-therapy CD4+ TEM expansion predicts hepatitis in CMV-seropositive patients, opening possibilities for avoidance or prevention. 3 of 4 patients with pre-treatment CD4+ TEM expansion who received αPD-1 monotherapy instead of αPD-1/αCTLA-4 therapy remained hepatitis-free. 4 of 4 patients with baseline CD4+ TEM expansion given prophylactic valganciclovir and αPD-1/αCTLA-4 therapy remained hepatitis-free. Our findings exemplify how pathogen exposure can shape clinical reactions after cancer therapy and how this insight leads to therapeutic innovations.
Decoupling the origins of irreversible coulombic efficiency in anode-free lithium metal batteries
Authors: Huang Chen-Jui , Thirumalraj Balamurugan , Tao Hsien-Chu , Shitaw Kassie Nigus , Sutiono Hogiartha , Hagos Tesfaye Teka , Beyene Tamene Tadesse , Kuo Li-Ming , Wang Chun-Chieh , Wu She-Huang , Su Wei-Nien , Hwang Bing Joe 
Published: March 2021

AbstractAnode-free lithium metal batteries are the most promising candidate to outperform lithium metal batteries due to higher energy density and reduced safety hazards with the absence of metallic lithium anode during initial cell fabrication. In general, researchers report capacity retention, reversible capacity, or rate capability of the cells to study the electrochemical performance of anode-free lithium metal batteries. However, evaluating the behavior of batteries from limited aspects may easily overlook other information hidden deep inside the meretricious results or even lead to misguided data interpretation. In this work, we present an integrated protocol combining different types of cell configuration to determine various sources of irreversible coulombic efficiency in anode-free lithium metal cells. The decrypted information from the protocol provides an insightful understanding of the behaviors of LMBs and AFLMBs, which promotes their development for practical applications.
Dataset on SARS-CoV-2 non-pharmaceutical interventions in Brazilian municipalities
Authors: de Souza Santos Andreza Aruska , Candido Darlan da Silva , de Souza William Marciel , Buss Lewis , Li Sabrina L. , Pereira Rafael H. M. , Wu Chieh-Hsi , Sabino Ester C. , Faria Nuno R. 
Published: March 2021

AbstractBrazil has one of the fastest-growing COVID-19 epidemics worldwide. Non-pharmaceutical interventions (NPIs) have been adopted at the municipal level with asynchronous actions taken across 5,568 municipalities and the Federal District. This paper systematises the fragmented information on NPIs reporting on a novel dataset with survey responses from 4,027 mayors, covering 72.3% of all municipalities in the country. This dataset responds to the urgency to track and share findings on fragmented policies during the COVID-19 pandemic. Quantifying NPIs can help to assess the role of interventions in reducing transmission. We offer spatial and temporal details for a range of measures aimed at implementing social distancing and the dates when these measures were relaxed by local governments.
3D Mueller matrix mapping of layered distributions of depolarisation degree for analysis of prostate adenoma and carcinoma diffuse tissues
Authors: Ushenko Volodymyr A. , Hogan Benjamin T. , Dubolazov Alexander , Piavchenko Gennadii , Kuznetsov Sergey L. , Ushenko Alexander G. , Ushenko Yuriy O. , Gorsky Mykhailo , Bykov Alexander , Meglinski Igor 
Published: March 2021

AbstractProstate cancer is the second most common cancer globally in men, and in some countries is now the most diagnosed form of cancer. It is necessary to differentiate between benign and malignant prostate conditions to give accurate diagnoses. We aim to demonstrate the use of a 3D Mueller matrix method to allow quick and easy clinical differentiation between prostate adenoma and carcinoma tissues with different grades and Gleason scores. Histological sections of benign and malignant prostate tumours, obtained by radical prostatectomy, were investigated. We map the degree of depolarisation in the different prostate tumour tissues using a Mueller matrix polarimeter set-up, based on the superposition of a reference laser beam with the interference pattern of the sample in the image plane. The depolarisation distributions can be directly related to the morphology of the biological tissues. The dependences of the magnitude of the 1st to 4th order statistical moments of the depolarisation distribution are determined, which characterise the distributions of the depolarisation values. To determine the diagnostic potential of the method three groups of histological sections of prostate tumour biopsies were formed. The first group contained 36 adenoma tissue samples, while the second contained 36 carcinoma tissue samples of a high grade (grade 4: poorly differentiated—4 + 4 Gleason score), and the third group contained 36 carcinoma tissue samples of a low grade (grade 1: moderately differentiated—3 + 3 Gleason score). Using the calculated values of the statistical moments, tumour tissues are categorised as either adenoma or carcinoma. A high level (> 90%) accuracy of differentiation between adenoma and carcinoma samples was achieved for each group. Differentiation between the high-grade and low-grade carcinoma samples was achieved with an accuracy of 87.5%. The results demonstrate that Mueller matrix mapping of the depolarisation distribution of prostate tumour tissues can accurately differentiate between adenoma and carcinoma, and between different grades of carcinoma. This represents a first step towards the implementation of 3D Mueller matrix mapping for clinical analysis and diagnosis of prostate tumours.
Specific microstructural changes of the cervical spinal cord in syringomyelia estimated by diffusion tensor imaging
Authors: Wu Weifei , Li Xiangxiang , Yang Zong , Ru Neng , Zhang Fan , Liang Jie , Zhang Ke 
Published: March 2021

AbstractThe microstructure of the spinal cord in syringomyelia has not been well studied. The aim of this study was to evaluate the microstructure of the cervical cord in patients with syringomyelia using diffusion tensor imaging (DTI) and to investigate the association between DTI parameters and the size of the syrinx cavity. Thirty patients with syringomyelia and 11 age-matched controls were included in this study. DTI and T1/T2-weighted MRI were used to estimate spinal microstructure. The patients were divided into a clinical symptom group (group A) and a non-clinical symptom group (group B) according to ASIA assessments. The fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values (mm2/s) were measured and compared between patients and controls. Correlation between FA/ADC and the size of the syrinx cavity was examined with a bivariate analysis. FA values were lower (P < 0.000) and ADC values were higher (P < 0.000) compared to the controls at the level of all syrinxes examined in patients with syringomyelia; both FA values and ADC values reached normal values either above or below the syrinx levels (all P > 0.05). FA values and ADC values at all cervical levels were not significantly different either in controls or outside of the syrinx (all P > 0.05). FA values of group A was significantly lower than those of group B (P < 0.000). There was a negative association between FA values and the size of syrinx cavity, and a positive association between ADC values and the size of syrinx cavity (FA: P < 0.05, ADC: P < 0.05). The microstructure of the cervical spinal cord is different across all patients with syringomyelia. DTI is a promising tool for estimating quantitative pathological characteristics that are not visible with general MRI.
Effect of Li+ doping on the luminescence performance of a novel KAlSiO4:Tb3+ green-emitting phosphor
Authors: Yantake Reziwanguli , Kaiheriman Muyasier , Yusufu Taximaiti , Sidike Aierken 
Published: March 2021

AbstractA new green-emitting phosphor, KAlSiO4:1.5 mol% Tb3+, x mol% Li+, was prepared via a high-temperature solid-phase method, and its crystal structure, diffuse reflectance spectrum, and luminescence were studied. The results show that the Li+ doping shifts the strongest diffraction peak to a high angle direction, reducing grain size by 11.4%. The entry of Li2CO3 improves the luminescence performance of KAlSiO4:1.5 mol% Tb3+. At a Li+ concentration of 1.5 mol%, the sample has strong absorption in the ultraviolet light range from 250 to 400 nm. The luminous intensity of the sample at 550 nm approximately quadruples after Li+ doping. Additionally, the colour purity of the sample and the internal quantum yield increase to 83.3% and 42%, respectively. The sample changes colour with time when exposed to air without an obvious fading phenomenon. The emission intensity at 200 °C is 95.1% of its value at room temperature, indicating that the phosphor has excellent thermal stability when x = 1.5. These results show the feasibility of using the silicate phosphor for generating the green light component of white light-emitting diodes for solid-state lighting.
Serial transplantation unmasks galectin-9 contribution to tumor immune escape in the MB49 murine model
Authors: Baloche Valentin , Rivière Julie , Tran Thi Bao Tram , Gelin Aurore , Bawa Olivia , Signolle Nicolas , Diop M′Boyba Khadija , Dessen Philippe , Beq Stéphanie , David Muriel , Busson Pierre 
Published: March 2021

AbstractMechanisms of tumor immune escape are quite diverse and require specific approaches for their exploration in syngeneic tumor models. In several human malignancies, galectin-9 (gal-9) is suspected to contribute to the immune escape. However, in contrast with what has been done for the infiltrating cells, the contribution of gal-9 produced by malignant cells has never been demonstrated in an animal model. Therefore, we derived isogenic clones—either positive or negative for gal-9—from the MB49 murine bladder carcinoma cell line. A progressive and consistent reduction of tumor growth was observed when gal-9-KO cells were subjected to serial transplantations into syngeneic mice. In contrast, tumor growth was unaffected during parallel serial transplantations into nude mice, thus linking tumor inhibition to the enhancement of the immune response against gal-9-KO tumors. This stronger immune response was at least in part explained by changing patterns of response to interferon-γ. One consistent change was a more abundant production of CXCL10, a major inflammatory factor whose production is often induced by interferon-γ. Overall, these observations demonstrate for the first time that serial transplantation into syngeneic mice can be a valuable experimental approach for the exploration of novel mechanisms of tumor immune escape.
Global, regional and national epidemiology and prevalence of child stunting, wasting and underweight in low- and middle-income countries, 2006–2018
Authors: Ssentongo Paddy , Ssentongo Anna E. , Ba Djibril M. , Ericson Jessica E. , Na Muzi , Gao Xiang , Fronterre Claudio , Chinchilli Vernon M. , Schiff Steven J. 
Published: March 2021

AbstractIn 2016, undernutrition, as manifested in childhood stunting, wasting, and underweight were estimated to cause over 1.0 million deaths, 3.9% of years of life lost, and 3.8% of disability-adjusted life years globally. The objective of this study is to estimate the prevalence of undernutrition in low- and middle-income countries (LMICs) using the 2006–2018 cross-sectional nationally representative demographic and health surveys (DHS) data and to explore the sources of regional variations. Anthropometric measurements of children 0–59 months of age from DHS in 62 LMICs worldwide were used. Complete information was available for height-for-age (n = 624,734), weight-for-height (n = 625,230) and weight-for-age (n = 626,130). Random-effects models were fit to estimate the pooled prevalence of stunting, wasting, and underweight. Sources of heterogeneity in the prevalence estimates were explored through subgroup meta-analyses and meta-regression using generalized linear mixed-effects models. Human development index (a country-specific composite index based on life expectancy, literacy, access to education and per capita gross domestic product) and the United Nations region were explored as potential sources of variation in undernutrition. The overall prevalence was 29.1% (95% CI 26.7%, 31.6%) for stunting, 6.3% (95% CI 4.6%, 8.2%) for wasting, and 13.7% (95% CI 10.9%, 16.9%) for underweight. Subgroup analyses suggested that Western Africa, Southern Asia, and Southeastern Asia had a substantially higher estimated prevalence of undernutrition than global average estimates. In multivariable meta-regression, a combination of human development index and United Nations region (a proxy for geographical variation) explained 54%, 56%, and 66% of the variation in stunting, wasting, and underweight prevalence, respectively. Our findings demonstrate that regional, subregional, and country disparities in undernutrition remain, and the residual gaps to close towards achieving the second sustainable development goal—ending undernutrition by 2030.
3D bioprinting of hepatocytes: core–shell structured co-cultures with fibroblasts for enhanced functionality
Authors: Taymour Rania , Kilian David , Ahlfeld Tilman , Gelinsky Michael , Lode Anja 
Published: March 2021

AbstractWith the aim of understanding and recapitulating cellular interactions of hepatocytes in their physiological microenvironment and to generate an artificial 3D in vitro model, a co-culture system using 3D extrusion bioprinting was developed. A bioink based on alginate and methylcellulose (algMC) was first shown to be suitable for bioprinting of hepatocytes; the addition of Matrigel to algMC enhanced proliferation and morphology of them in monophasic scaffolds. Towards a more complex system that allows studying cellular interactions, we applied core–shell bioprinting to establish tailored 3D co-culture models for hepatocytes. The bioinks were specifically functionalized with natural matrix components (based on human plasma, fibrin or Matrigel) and used to co-print fibroblasts and hepatocytes in a spatially defined, coaxial manner. Fibroblasts acted as supportive cells for co-cultured hepatocytes, stimulating the expression of certain biomarkers of hepatocytes like albumin. Furthermore, matrix functionalization positively influenced both cell types in their respective compartments by enhancing their adhesion, viability, proliferation and function. In conclusion, we established a functional co-culture model with independently tunable compartments for different cell types via core–shell bioprinting. This provides the basis for more complex in vitro models allowing co-cultivation of hepatocytes with other liver-specific cell types to closely resemble the liver microenvironment.