bluuebunny/crossref_metadata_2025_split huggingface dataset:
The PNUTS-PAD domain recruits MYC to the PNUTS:PP1 phosphatase complex via the oncogenic MYC-MB0 region
Authors: Wei Yong , Ahlner Alexandra , Redel Cornelia , Lemak Alexander , Johansson-Åkhe Isak , Houliston Scott , Kenney Tristan M.G. , Tamachi Aaliya , Morad Vivian , Duan Shili , Andrews David W. , Wallner Björn , Sunnerhagen Maria , Arrowsmith Cheryl H. , Penn Linda Z. 
Published: December 2021

SummaryDespite MYC dysregulation in most human cancers, strategies to target this potent oncogenic driver remains an urgent unmet need. Recent evidence shows the PP1 phosphatase and its regulatory subunit PNUTS control MYC phosphorylation and stability, however the molecular basis remains unclear. Here we demonstrate that MYC interacts directly with PNUTS through the MYC homology Box 0 (MB0), a highly conserved region recently shown to be important for MYC oncogenic activity. MB0 interacts with PNUTS residues 1-148, a functional unit here termed, PNUTS amino-terminal domain (PAD). Using NMR spectroscopy we determined the solution structure of PAD, and characterised its interaction with MYC. Point mutations of residues at the MYC-PNUTS interface significantly weaken their interaction both in vitro and in vivo. These data demonstrate the MB0 binding pocket of the PAD represents an attractive site for pharmacological disruption of the MYC-PNUTS interaction.In BriefSolving the structure of MYC-PNUTS direct interaction reveals how the intrinsically disordered MYC-Box0 (MB0) region anchors into a binding pocket in the N-terminal PAD domain of PNUTS. These data provide insight into the molecular mechanism of how the PNUTS:PP1 phosphatase complex regulates MYC phosphorylation.HighlightsA region critical for MYC oncogenesis, MYC-Box0 (MB0), directly interacts with PNUTSPNUTS amino-terminal domain (PAD) is a structural domain that interacts with MYC MB0Mutation of single residues at the interaction interface disrupts MYC-PNUTS binding in cellsMYC-PNUTS binding releases MYC intramolecular interactions to enable PP1substrate access
Learning progress mediates the link between cognitive effort and task engagement
Authors: Sayalı Ceyda , Heling Emma , Cools Roshan 
Published: December 2021

ABSTRACTWhile a substantial body of work has shown that cognitive effort is aversive and costly, a separate line of research on intrinsic motivation suggests that people spontaneously seek challenging tasks. According to one prominent account of intrinsic motivation, the Learning Progress Motivation theory, the preference for difficult tasks reflects the dynamic range that these tasks yield for changes in task performance (Oudeyer, Kaplan & Hafner, 2007). Here we test this hypothesis, by asking whether greater engagement with intermediately difficult tasks, indexed by subjective ratings and objective pupil measurements, is a function of trial-wise changes in performance. In a novel paradigm, we determined each individual’s capacity for task performance and used difficulty levels that are too low, intermediately challenging or high for that individual. We demonstrated that challenging tasks resulted in greater liking and engagement scores compared with easy tasks. Pupil size tracked objective task difficulty, where challenging tasks were associated with greater pupil responses than easy tasks. Most importantly, pupil responses were predicted by trial-to-trial changes in average accuracy as well as learning progress (derivative of average accuracy), while greater pupil responses also predicted greater subjective engagement scores. Together, these results substantiate the Learning Progress Motivation hypothesis stating that the link between task engagement and cognitive effort is mediated the dynamic range for changes in task performance.
Miniature Structured Illumination Microscope for in vivo 3D Imaging of Brain Structures with Optical Sectioning
Authors: Supekar Omkar D. , Sias Andrew , Hansen Sean R. , Martinez Gabriel , Peet Graham C. , Peng Xiaoyu , Bright Victor M. , Hughes Ethan G. , Restrepo Diego , Shepherd Douglas P. , Welle Cristin G. , Gopinath Juliet T. , Gibson Emily A. 
Published: December 2021

AbstractWe present a high-resolution miniature, light-weight fluorescence microscope with electrowetting lens and onboard CMOS for high resolution volumetric imaging and structured illumination for rejection of out-of-focus and scattered light. The miniature microscope (SIMscope3D) delivers structured light using a coherent fiber bundle to obtain optical sectioning with an axial resolution of 18 μm. Volumetric imaging of eGFP labeled cells in fixed mouse brain tissue at depths up to 220 μm is demonstrated. The functionality of SIMscope3D to provide background free 3D imaging is shown by recording time series of microglia dynamics in awake mice at depths up to 120 μm in the brain.
AKT1 is Required for a Complete Palbociclib-induced Senescence Phenotype in BRAF-V600E-Driven Human Melanoma
Authors: Bayer Abraham L. , Pietruska Jodie , Farrell Jaymes , McRee Siobhan , Alcaide Pilar , Hinds Philip W. 
Published: December 2021

AbstractCellular senescence is a carefully regulated process of proliferative arrest accompanied by numerous functional and morphologic changes. Senescence allows damaged cells to avoid neoplastic proliferation, however induction of the senescence-associated secretory phenotype (SASP) can promote tumor growth. The complexity of the senescence response may limit the efficacy of anti-neoplastic agents, such as CDK4/6 inhibitors (Cdk4/6i), that induce a senescence-like, non-proliferative state in tumor cells. The AKT kinase family plays an important role in cellular growth and division, and is commonly hyperactive in many cancers including melanoma. AKT activity has also been implicated in regulation of senescence. The three AKT isoforms play both redundant and unique roles in tumorigenesis and cancer progression. To interrogate the role of AKT isoforms in the induction of cellular senescence by Cdk4/6i, we generated isoform specific AKT knockout human BRAF-V600E mutated melanoma cell lines. We found that the CDK4/6i Palbociclib induced a form of senescence in these cells that was dependent on AKT1. As a potential mechanism, we evaluated the activity of the cGAS-STING pathway, recently implicated in cellular senescence. While we showed cGAS-STING function to be dependent on AKT1, pharmacologic inhibition of either cGAS or STING had little effect on senescence. However, we found SASP factors to require NF-kB function, in part dependent on a stimulatory phosphorylation of IKKα by AKT1 previously reported in other models. In summary, we provide the first evidence of a novel, isoform specific role for AKT1 in therapy-induced senescence in human melanoma cells acting through NF-kB but independent of cGAS-STING.
Fractal scaling of C. elegans behavior is shaped by insulin signaling
Authors: Arata Yukinobu , Shiga Itsuki , Ikeda Yusaku , Jurica Peter , Kimura Hiroshi , Kiyono Ken , Sako Yasushi 
Published: December 2021

AbstractFractal scaling governs the complex behavior of various animal species and, in humans, can be altered by neurodegenerative diseases and aging1. However, the mechanism underlying fractal scaling remains unknown. Here, we videorecorded C. elegans that had been cultured in a microfluidic device for 3 days and analyzed temporal patterns of C. elegans actions by fractal analyses. The residence-time distribution of C. elegans shared a common feature with those of human and mice2–4. Specifically, the residence-time power-law distribution of the active state changed to an exponential-like decline at a longer time scale, whereas this change did not occur in the inactive state. The exponential-like decline disappeared in starved C. elegans but was restored by culturing animals with glucose. The exponential-like decline similarly disappeared in insulin-signaling daf-2 and daf-16 mutants. Therefore, we conclude that insulin signaling regulates fractal scaling of C. elegans behavior. Our findings indicate that neurosensory modulation of C. elegans behavior by insulin signaling is achieved by regulation of fractal scaling. In humans, diabetes mellitus is associated with depression, bipolar disorder, and anxiety disorder5, which affect daily behavioral activities. We hypothesize that comorbid behavioral defects in patients with diabetes may be attributed to altered fractal scaling of human behavior.
Corporate sustainability performance and informativeness of earnings
Authors: Saini Jagjit Singh , Feng Mingming , DeMello Jim 
Published: December 2021

PurposeWith the growing awareness about the environment and climate, sustainability has gained increased attention of investors. Many investors now factor in the long-term sustainability of successful and responsible companies when making their investment choices. The purpose of this paper is to investigate whether or not the sustainability performance of a company affects the informativeness of its earnings by exploring the mediating effect of sustainability performance on the association between stock returns and earnings changes.Design/methodology/approachUsing a sample of firms for the period 2009–2016 with available sustainability data from TruValue Labs' database, the authors investigate how the sustainability performance of a firm mediates the relationship between stock returns and earnings (changes). The authors use ordinary least squares (OLS) regressions to test their hypotheses.FindingsConsistent with the voluntary disclosure and environmental, social and governance (ESG) performance literature, the authors find that higher sustainability performance improves the stock price informativeness of earnings. The authors find evidence in support of increased earnings response coefficient with increased sustainability performance.Research limitations/implicationsThis study adds to the literature supporting the notion of sustainability investing indicating that sustainability performance of a firm affects the stock price informativeness and predictability of earnings (changes) of the firm.Originality/valueThis study has value for, both, investors and managers regarding the importance of sustainability performance of the firm. Sustainability performance of the firm sends signals to market participants, increasing the informational content of the reported earnings as well as predictability of future earnings.
Cross-network propagation model of public opinion information and its control in coupled double-layer online social networks
Authors: Li Yun , Wang Jiakun 
Published: December 2021

PurposeIn modern society, considering the multi-channel of public opinion information (public opinion) propagation and its strong influence on social development, it is necessary to study its propagation law and discuss the intervention strategy in online social networks (OSN).Design/methodology/approachFirst, a conceptual model of double-layer OSN was constructed according to their structural characteristics. Then, a cross-network propagation model of public opinion in double-layer OSN was proposed and discussed its spreading characteristics through numerical simulations. Finally, the control strategy of public opinion, especially the timing and intensity of intervention were discussed.FindingsThe results show that the double-layer OSN promotes the propagation of public opinion, and the propagation of public opinion in double-layer OSN has the characteristics of that in two single-layer OSN. Compared with the intervention intensity, the regulator should give the priority to the timing of intervention and try to intervene in the early stage of public opinion propagation.Practical implicationsThis study may help the regulators to respond to the propagation of public opinion in OSN more actively and reasonably.Originality/valueThis research has a deep comprehension of the cross-network propagation rules of public opinion and manages the propagation of public opinion.
Career satisfaction, subjective well-being and turnover intention: an attachment style perspective
Authors: Nae Eun Young , Choi Byoung Kwon 
Published: December 2021

PurposeOn the basis of an attachment style perspective, the authors explored a moderated mediation model in which career satisfaction reduces employees' turnover intention by enhancing subjective well-being; this mediated relationship would be moderated by three dimensions of attachment style as follows: secure, counterdependent and overdependent.Design/methodology/approachData were collected from 192 employees in South Korea and hypotheses were tested using multiple regression analysis and the PROCESS macro for SPSS.FindingsSubjective well-being mediated the relationship between career satisfaction and turnover intention. The indirect relationship between career satisfaction and turnover intention through subjective well-being was significant only when employees had high-secure attachment and low-counterdependent and -overdependent attachment styles.Practical implicationsOn the basis of the authors' findings that not all employees' subjective well-being translates into a lower level of turnover intention despite being satisfied with their career, the study suggests that organizations should pay more attention to how the subjective well-being of employees can be enhanced in relation to their career by considering their attachment styles.Originality/valueThe study contributes to deepening the understanding of the mechanism of when and how career satisfaction reduces turnover intention by integrating subjective well-being and attachment styles that have been neglected in prior research.
Ayanda Mbatha: resilience in action during the COVID-19 pandemic (A & B)
Authors: Magwegwe Frank 
Published: December 2021

Complexity/Academic level
Undergraduate, postgraduate and corporate education.

Case overview
This case describes Ayanda Mbatha’s response, attitudes and beliefs after retrenched from his position as a technician and draughtsman at Rheinmetall Denel Munition during the COVID-19 pandemic. Mbatha responded with resilience to losing his job. Mbatha’s attitudes and beliefs enabled him to creatively search for a new job amidst escalating retrenchments. The case examines the factors important for resilience and demonstrates why resilience is an essential skill for individuals dealing with adversity. The case dilemma involves the choices Mbatha had to make during and after the retrenchment process initiated by his employer.

Expected learning outcome
We designed this case to facilitate the understanding of what is resilience and why resilience is an essential skill for individuals facing adversity. Specifically, the case aims to help students to: 1. Describe the construct of resilience in the context of individuals. 2. Identify factors that promote resilience. 3. Explain what resilient individuals do in the face of adversity. 4. Evaluate the importance of resilience during adversity. 5. Evaluate the role of prior adversity in the development of resilience.

Supplementary materials
Teaching Notes are available for educators only.

Subject code
CSS 6: Human Resource Management.
The synergistic impact between internationalization and supply-and-demand interaction on firm performance: a study of environmental responsibility in social networking service
Authors: Kim YooJung , Seo Yejung 
Published: December 2021

PurposeThis study aims to investigate the relationship between environmental activities and consumer engagement on firm performance according to supply-and-demand perceptions, and further examines the moderating role of internationalization to demonstrate the effects of environmental activities more comprehensively.Design/methodology/approachThree panel regression models have been used. In total, 510 environmental activities and consumers’ negative engagement collected from the official Facebook brand page are analyzed to examine the study’s models for a period of 13-years (2008–2020). The findings persist when this study compares the estimates resulted from different econometrics methods.FindingsThe study’s results indicate an insignificant effect of environmental activities and consumer engagement on firm performance, respectively, while the interaction effect on firm performance is significant and negative. However, when internationalization plays the moderating role, this study provides new evidence that such negativity impact is no longer effective in the lodging industry as firms expand internationally.Practical implicationsThis study offers strategic insights to managers who are concerned about the detrimental effect of negative consumer engagement that the firm-consumer relationship mitigates the negativity bias in negative engagement. Hotels should actively implement internationalization as a key strategy while practicing environmental activities with integrity.Originality/valueDespite the importance of green management in the social networking service context, little is known about its effect and value on firm performance. This study provides new evidence for the real effectiveness of internationalization by demonstrating its role in the lodging industry.
Developing a sustainable career through discourse: a qualitative study on a group of Italian project managers
Authors: Lo Presti Alessandro , Manuti Amelia , De Rosa Assunta , Elia Angelo 
Published: December 2021

PurposeThe current study makes two main contributions: one theoretical and one methodological. First, it investigated the theoretical prepositions of career sustainability perspective, which appears particularly suitable for examining project managers' careers' dynamics and patterns, featured by explicit and recursive interactions between individual, temporal and contextual factors. Second, the study aimed to adopt a qualitative approach to this topic as to allow a deeper understanding of individual narratives about careers, highlighting underexplored issues and peculiarities that future research could further examine through quantitative methodologies.Design/methodology/approachProject managers' careers are still an under-researched topic, especially through qualitative methods. The study applied career sustainability theory to the realm of project management, moreover, adopting a socio-constructivist perspective. Participants were 50 Italian project managers who were involved through a narrative in-depth interview that focused on career and career success. Their answers were analyzed through thematic analysis of contents and diatextual analysis.FindingsResults showed that project managers' career could be a prototypical example of sustainable career, basically described in terms of four basic constitutive dimensions as follows: time frame, social space, agency and meaning. Implications for both future theoretical expansion of career sustainability theory and project managers' career management interventions were also discussed.Originality/valueThe originality of the paper could be found in the effort to adopt a socio-constructivist perspective to investigate the topic of career sustainability taking the exemplary case of project managers' career.
Reinforcing customer journey through artificial intelligence: a review and research agenda
Authors: Rana Jyoti , Gaur Loveleen , Singh Gurmeet , Awan Usama , Rasheed Muhammad Imran 
Published: December 2021

PurposeThis study defines a three-angled research plan to intensify the knowledge and development undergoing in the retail sector. It proposes a theoretical framework of the customer journey to explain the customers' intent to adopt artificial intelligence (AI) and machine learning (ML) as a protective measure for interaction between the customer and the brand.Design/methodology/approachThis study presents a research agenda from three-dimensional online search, ML and AI algorithms. This paper enhances the readers' understanding by reviewing the literature present in utilizing AI in the customer journey and presenting a theoretical framework.FindingsUsing AI tools like Chatbots, Recommenders, Virtual Assistance and Interactive Voice Recognition (IVR) helps create improved brand awareness, better customer relationships marketing and personalized product modification.Originality/valueThis study intends to identify a research plan based on investigating customer journey trends in today's changing times with AI incorporation. The research provides a novel model framework of the customer journey by directing customers into different stages and providing different touchpoints in each stage, all supported with AI and ML.
Employee engagement as a mediating variable on the relationship between employee relation practice and employee performance in a developing economy
Authors: Abdullahi Mohammed Sani , Raman Kavitha , Solarin Sakiru Adebola , Adeiza Adams 
Published: December 2021

PurposeThe aim of this research is to investigate the mediating effect of employee engagement (EE) on the relationship between employee relation practice and employee performance in Malaysian private universities (MPUs).Design/methodology/approachThis paper used a survey research design, and the study unit of the analysis consists of the academic staff of MPU. A sample of 314 teaching staff was used out of the target population (10,473) of the research, while simple random and stratified sampling techniques were used in order to determine the research sample. Data for the research were collected from the target participants via questionnaires, and partial least square-structural equation modelling (PLS-SEM) was utilized to evaluate the research hypotheses.FindingsThe outcome of the research revealed that employee relation practice (ERP) has a substantial effect on employee performance (EP), and EE partially mediates the relationship between ERP and EP.Practical implicationsThe outcome of this study has urged the universities' management to focus on building effective and sustainable ERP that will ensure academic engagement that can result to sound academic performance and university growth.Originality/valueThis research has contributed significantly to the body of knowledge by operationalizing EP, ERP and EE literature. In extension, this research contributes to develop the literature of leaders, acknowledging the ERP as an important tool for leadership growth.
Image manipulation in scholarly publications: are there ways to an automated solution?
Authors: Beck Thorsten Stephan 
Published: December 2021

PurposeThis paper provides an introduction to research in the field of image forensics and asks whether advances in the field of algorithm development and digital forensics will facilitate the examination of images in the scientific publication process in the near future.Design/methodology/approachThis study looks at the status quo of image analysis in the peer review process and evaluates selected articles from the field of Digital Image and Signal Processing that have addressed the discovery of copy-move, cut-paste and erase-fill manipulations.FindingsThe article focuses on forensic research and shows that, despite numerous efforts, there is still no applicable tool for the automated detection of image manipulation. Nonetheless, the status quo for examining images in scientific publications remains visual inspection and will likely remain so for the foreseeable future. This study summarizes aspects that make automated detection of image manipulation difficult from a forensic research perspective.Research limitations/implicationsResults of this study underscore the need for a conceptual reconsideration of the problems involving image manipulation with a view toward the need for interdisciplinary collaboration in conjunction with library and information science (LIS) expertise on information integrity.Practical implicationsThis study not only identifies a number of conceptual challenges but also suggests areas of action that the scientific community can address in the future.Originality/valueImage manipulation is often discussed in isolation as a technical challenge. This study takes a more holistic view of the topic and demonstrates the necessity for a multidisciplinary approach.