bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oroxylin a Attenuates Limb Ischemia by Promoting Angiogenesis via Modulation of Endothelial Cell Migration
Authors: Zhang Lusha , Chen Lu , Li Chunxiao , Shi Hong , Wang Qianyi , Yang Wenjie , Fang Leyu , Leng Yuze , Sun Wei , Li Mengyao , Xue Yuejin , Gao Xiumei , Wang Hong 
Published: July 2021

Oroxylin A (OA) has been shown to simultaneously increase coronary flow and provide a strong anti-inflammatory effect. In this study, we described the angiogenic properties of OA. OA treatment accelerated perfusion recovery, reduced tissue injury, and promoted angiogenesis after hindlimb ischemia (HLI). In addition, OA regulated the secretion of multiple cytokines, including vascular endothelial growth factor A (VEGFA), angiopoietin-2 (ANG-2), fibroblast growth factor-basic (FGF-2), and platelet derived growth factor BB (PDGF-BB). Specifically, those multiple cytokines were involved in cell migration, cell population proliferation, and angiogenesis. These effects were observed at 3, 7, and 14 days after HLI. In skeletal muscle cells, OA promoted the release of VEGFA and ANG-2. After OA treatment, the conditioned medium derived from skeletal muscle cells was found to significantly induce endothelial cell (EC) proliferation. OA also induced EC migration by activating the Ras homolog gene family member A (RhoA)/Rho-associated coiled-coil kinase 2 (ROCK-II) signaling pathway and the T-box20 (TBX20)/prokineticin 2 (PROK2) signaling pathway. In addition, OA was able to downregulate the number of macrophages and neutrophils, along with the secretion of interleukin-1β, at 3 days after HLI. These results expanded current knowledge about the beneficial effects of OA in angiogenesis and blood flow recovery. This research could open new directions for the development of novel therapeutic intervention for patients with peripheral artery disease (PAD).
Long-Term Outcomes and Predictors of Childhood-Onset Schizophrenia: A Naturalistic Study of 6-year Follow-Up in China
Authors: Liangrong Zheng , Guican Zhang , Qi Zhu , Weirui Yang , Yaqi Zhang , Tong Li , Wenjing Liang , Ming Zhang , Nianhong Guan 
Published: July 2021

Objectives:The long-term outcome of childhood-onset schizophrenia (COS) and its influencing factors remain unclear. The current study aimed to assess the long-term outcomes of COS and identify possible outcome predictors.Methods:We retrospectively investigated 276 patients with COS. Diagnosis made according to the ICD-10 criteria for schizophrenia, and the age of the first onset was ≤ 14 years. Follow-up was completed for 170 patients, with a median follow-up period of 5.6 years. Outcome variables included occupational/education status and readmission. Spearman correlation was performed to assess the relationship between predictors and outcome variables. Binary logistic regression was conducted to detect possible predictor variables for outcome variables.Results:At the end of the follow-up, 89 patients (52.3%) were at school, 70 patients (41.2%) were employed, and only 11 patients (6.5%) were dropped out of school or unemployed. The duration to the first admission and depressive symptoms were identified as predictors of occupational/educational status. The length of follow-up and obsessive-compulsive symptoms (OCS) were distinguished as predictors of readmission. Duration to the first admission and length of follow-up were risk factors, and depressive symptoms and OCS were protective factors for the outcomes of COS.Conclusion:We found a favorable long-term outcome on occupational/education status in COS, and depressive symptoms and OCS may be associated with more positive long-term outcomes in COS. Our findings suggest that COS patients may benefit from early intervention and require appropriate treatment.
The Clinical Impacts of Mobile Mood-Monitoring in Young People With Mental Health Problems: The MeMO Study
Authors: Dubad Muna , Elahi Farah , Marwaha Steven 
Published: July 2021

Background: Limited evidence suggests that mobile mood-monitoring can improve mental health outcomes and therapeutic engagement in young people. The aim of this mixed methods study was to explore the clinical impacts of mobile mood-monitoring in youth with mental health problems, using a publicly accessible app.Methods: Twenty-three patients with mental health problems and 24 young people without mental health problems participated in the quantitative study. Participants monitored their mood using a mood-monitoring app twice a day for 3 weeks, which was preceded by a 3-week baseline period. Outcome measures included momentary and retrospective assessments of affect regulation (all participants) and therapeutic engagement (patients only). Following the quantitative study, patients (n = 7) and their clinicians (n = 6) participated in individual interviews. Interview data was analysed using thematic analysis.Results: Use of the mood-monitoring app significantly reduced momentary negative mood (p &lt; 0.001) and retrospectively assessed impulsivity across all 47 participants (p = 0.001). All other outcomes showed no significant difference. Qualitative feedback similarly indicated the potential of apps to improve problems with impulsivity in patients. Furthermore, apps may aid communication, promote empowerment, and ameliorate memory difficulties in clinical appointments.Conclusions: This mixed methods study demonstrated the potential utility of apps for clinical practice. Apps may potentially be an interventional tool, or at a minimum, an adjunct to existing treatments. Data was collected from a small sample size over a short study duration, limiting the generalisability of findings and inferences regarding long-term effects. Potential sources of bias in the qualitative study (e.g., researcher bias) should also be considered.
Molecular Phylogenesis and Spatiotemporal Spread of SARS-CoV-2 in Southeast Asia
Authors: Zhu Mingjian , Shen Jian , Zeng Qianli , Tan Joanna Weihui , Kleepbua Jirapat , Chew Ian , Law Jia Xian , Chew Sien Ping , Tangathajinda Anita , Latthitham Natthjija , Li Lanjuan 
Published: July 2021

Background: The ongoing coronavirus disease 2019 (COVID-19) pandemic has posed an unprecedented challenge to public health in Southeast Asia, a tropical region with limited resources. This study aimed to investigate the evolutionary dynamics and spatiotemporal patterns of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the region.Materials and Methods: A total of 1491 complete SARS-CoV-2 genome sequences from 10 Southeast Asian countries were downloaded from the Global Initiative on Sharing Avian Influenza Data (GISAID) database on November 17, 2020. The evolutionary relationships were assessed using maximum likelihood (ML) and time-scaled Bayesian phylogenetic analyses, and the phylogenetic clustering was tested using principal component analysis (PCA). The spatial patterns of SARS-CoV-2 spread within Southeast Asia were inferred using the Bayesian stochastic search variable selection (BSSVS) model. The effective population size (Ne) trajectory was inferred using the Bayesian Skygrid model.Results: Four major clades (including one potentially endemic) were identified based on the maximum clade credibility (MCC) tree. Similar clustering was yielded by PCA; the first three PCs explained 46.9% of the total genomic variations among the samples. The time to the most recent common ancestor (tMRCA) and the evolutionary rate of SARS-CoV-2 circulating in Southeast Asia were estimated to be November 28, 2019 (September 7, 2019 to January 4, 2020) and 1.446 × 10−3 (1.292 × 10−3 to 1.613 × 10−3) substitutions per site per year, respectively. Singapore and Thailand were the two most probable root positions, with posterior probabilities of 0.549 and 0.413, respectively. There were high-support transmission links (Bayes factors exceeding 1,000) in Singapore, Malaysia, and Indonesia; Malaysia involved the highest number (7) of inferred transmission links within the region. A twice-accelerated viral population expansion, followed by a temporary setback, was inferred during the early stages of the pandemic in Southeast Asia.Conclusions: With available genomic data, we illustrate the phylogeography and phylodynamics of SARS-CoV-2 circulating in Southeast Asia. Continuous genomic surveillance and enhanced strategic collaboration should be listed as priorities to curb the pandemic, especially for regional communities dominated by developing countries.
I Know Some People: The Association of Social Capital With Primary Health Care Utilization of Residents in China
Authors: Zhang Weiwei , Huang Yuankai , Lu Mengqing , Lin Guohua , Wo Tian , Xi Xiaoyu 
Published: July 2021

Background: Primary health care (PHC) services are underused due to the unbalanced distribution of medical resources. This is especially true in developing countries where the construction of PHC systems has begun to take effect. Social capital is one of the important factors affecting primary health care utilization.Method: This study investigated the utilization of PHC services by Chinese community residents in the past year. Social capital, PHC utilization, age, health care insurance, etc., were measured. A multilevel negative binomial model was adopted to analyze the association of social capital with PHC utilization.Results: Data of 5,471 residents from 283 communities in China were collected through a questionnaire survey in 2018. The results showed that community social capital (CSC) is significantly associated with PHC utilization in China, but individual social capital (ISC) had no significant association with PHC utilization. A one-standard deviation increase in the CSC leads to a 1.9% increase in PHC utilization. Other factors like gender, education, income, health insurance, health status, etc., are significantly associated with PHC utilization in China.Conclusions: Community social capital plays a more important role in promoting PHC utilization, while ISC plays an unclear role in PHC utilization by the residents of China.
FBG-Based Estimation of External Forces Along Flexible Instrument Bodies
Authors: Al-Ahmad Omar , Ourak Mouloud , Vlekken Johan , Vander Poorten Emmanuel 
Published: July 2021

A variety of medical treatment and diagnostic procedures rely on flexible instruments such as catheters and endoscopes to navigate through tortuous and soft anatomies like the vasculature. Knowledge of the interaction forces between these flexible instruments and patient anatomy is extremely valuable. This can aid interventionalists in having improved awareness and decision-making abilities, efficient navigation, and increased procedural safety. In many applications, force interactions are inherently distributed. While knowledge of their locations and magnitudes is highly important, retrieving this information from instruments with conventional dimensions is far from trivial. Robust and reliable methods have not yet been found for this purpose. In this work, we present two new approaches to estimate the location, magnitude, and number of external point and distributed forces applied to flexible and elastic instrument bodies. Both methods employ the knowledge of the instrument’s curvature profile. The former is based on piecewise polynomial-based curvature segmentation, whereas the latter on model-based parameter estimation. The proposed methods make use of Cosserat rod theory to model the instrument and provide force estimates at rates over 30 Hz. Experiments on a Nitinol rod embedded with a multi-core fiber, inscribed with fiber Bragg gratings, illustrate the feasibility of the proposed methods with mean force error reaching 7.3% of the maximum applied force, for the point load case. Furthermore, simulations of a rod subjected to two distributed loads with varying magnitudes and locations show a mean force estimation error of 1.6% of the maximum applied force.
Implementation of the recognition and respect of the Dayak Iban Semunying customary law community in human rights and SDGs
Authors: Christmas Sandy Kurnia , Muhajir Ichsan , Wicaksono Imam 
Published: July 2021

Weak implementation of the recognition and respect for Indigenous Peoples of Iban Semunying be problems related to their discriminatory practices in running a government policy. Why is the implementation of the recognition and respect for the Indigenous People of Dayak Iban Semunying still weak and how the principles of human rights and the Sustainable Development Goals are the two issues raised in this article. In this study it aims to find out what are the things that form the basis of the weak protection of indigenous peoples. The results of this study are expected to provide insight into the protection of the rights of indigenous peoples with a perspective of sustainable development goals.
The Requirements for Replacement of Elected Legislative Candidates for Election Based on Democratic Principles
Authors: Haedar Muhammad Iqbal Maulana 
Published: July 2021

The research method used is Normative Juridical with a form of data collection by observation and documentation. This research aims to be able to know and analyze how the application of democratic principles and legal implications in the implementation of replacement of elected legislative candidates. The results of the study showed that there are differences in interpretation of the authority in terms of replacement of prospective legislative members elected. Political parties consider themselves to have absolute authority, while based on its rules the KPU should have that authority. Regarding the legal implications of the candidates of elected legislators who are dismissed by his party of course make the elected candidates in question are not appointed as members of the legislature and also give rise to biased legal certainty. Whereas in the legal process has been found the results of a final and binding ruling from the Makassar State Administrative Court.
Setting The Principles of Democracy in The Appointment of A Single Candidate Spouse of Regional Heads
Authors: Nur Rahmat 
Published: July 2021

This research aims to analyzethe regulation of democratic principles in filling the position of regional head in single candidatepai. This study uses normative juridical research by conducting legal analysis of legislation related to the filling of local government positions and legal issues related to the Decision of the Constitutional Court No. 100/PUU-XIII/2015 on the constitutional requirements of regional head elections (candidates' spouses). The results showed the regulation of democratic principles in filling the position of regional head in the case of a single candidate pair can use two mechanisms, namely using the electoral mechanism (Basedon Law No. 10 of 2016 as a follow-up to the Decision of Mk No. 100/PUU-XIII/2015) or the mechanism of appointment, as long as the appointment is done by officials who have been directly elected. Furthermore, the arrangement of the mechanism of appointing a single candidate of regional head in Indonesia can follow what has been implemented in the United States that implements uncontested elections if after the nomination period ends still produces only one candidate, then the candidate's spouse is immediately considered valid as the spouse of the elected candidate and can be legally appointed as the head of the new period. Filling the position of regional head that there is only 1 (one) candidate pair is using the mechanism of appointment, while if there are 2 (two) pairs of candidates or more still use the election mechanism.
Intervención de la Facultad de Derecho y Ciencias Políticas de la Universidad de Ibagué en la demanda de inconstitucionalidad contra el artículo 223 de la Ley 906 de 2004. Sentencia C-480-20
Authors: Vargas Castro Sandra Bibiana 
Published: July 2021

Las demandas de inconstitucionalidad hacen parte del ejercicio democrático mediante el cual el ciudadano acude a la jurisdicción constitucional, en busca de proponer por parte de la Corte el análisis de una norma que se acusa de contradecir la Constitución.
Las universidades del país son invitadas a participar en el trámite inicial que surte la demanda, con el propósito de proporcionar su interpretación jurídica entre la norma demandada y la Constitución Política. Este ejercicio previo a la decisión final de la Corte Constitucional se ha convertido en un espacio valioso de expresión de la voz académica en el contexto práctico de una decisión judicial.
El lector encontrará a continuación, el concepto proyectado por la profesora Sandra Bibiana Vargas Castro y presentado por Hernando A. Hernández Quintero, decano de la Facultad de Derecho y Ciencias Políticas, en representación de esta unidad académica en el trámite de la demanda de inconstitucionalidad de la norma dispuesta en el artículo 223 de la Ley 906 de 2004 “Por la cual se expide el Código de Procedimiento Penal”. Esta controversia jurídica fue resuelta mediante la Sentencia C-480-20 que puede ser consultada aquí.
The Effectivity of Ozonated VCO on Healing Full Grafted Skin graft Study on Progenitor Cell Endothelial Proliferation and Angiogenesis in Sprague Dawley Mice
Authors: Sidauruk Rollin Hansen , Yuniati Renny , Handojo Djoko 
Published: July 2021

Abstract

Background : Full thickness Skin graft is one technique to accelerate wound healing. EPC proliferation and new blood vessel formation have an important role in the success of Ful thickness Skin graft. Ozone content in Ozonated VCO has the ability to increase growth factors so that it can accelerate wound healing

Aims : This study was aimed to prove the effects of ozonated vco in various doses in increasing EPC proliferation and angiogenesis in full thickness skin graft wounds.

Methods : This research is an experimental study with randomized post test only with parallel group design. 40 Sprague Dawley rats performed autologous Skin grafts at the same time. Samples were randomly divided into 8 groups, two control groups (X1 and X5), and 6 other groups were given a multi-dose ozonated oil 50.6 mg / ml (X2, X6), 101.3 mg / ml (X3, X7) , 202.6 mg / ml (X4, X8). Conduct termination on day 6 and day 12. Examination of the number of EPC proliferation and the number of angiogenesis in each group. Data were analyzed by Saphiro Wijk, ANOVA, post hoc benferonni and pearsons

Results : The number of EPC proliferation in groups X1, X2, X3, X4, X5, X6, X7, X8 has a mean of 6.2 + 0.837, 10 + 1.581, 13.80 + 2.049, 14.80+ 2,280, 9.40 + 2,074 , 13.20 + 1,483, 19,0 + 2,055 and 19.20 + 1,095.The number of Angiogenesis in groups X5, X6, X7, X8 has a mean of 9.20 + 1,095,14,60 + 2,881,17,40+ 3,286, 18,80 + 2,168,17,40 + 3,286,18.80+ 2,168. The administration of ozonated VCO dose of 202.6 mg / ml gave the best results in the amount of angiogenesis (p = 0.001) and the amount of angiogenesis (p=0,001).Correlation analysis between EPC proliferation and angiogenesis showed a significant correlation (p = 0.001 and r = 0.738).

Conclusion : Ozonated oil can increase the number of EPC proliferation and angiogenesis in the wound healng process of Full thickness Skin graft. The ozone dose of 202,6 mg / ml showed the best effect on increase wound healing process.
Keyword : Full thickness skin graft, Ozonated oil , EPC, Angiogenesis
Fungsi Pancasila sebagai Perekat Persatuan Bangsa dengan Efektivitas Kegiatan Belajar di Luar Kelas
Authors: Rachmadi Rachmadi 
Published: July 2021

Salah satu metode pembelajaran yang lebih memberdayakan siswa dan sesuai dengan K13 adalah metode pembelajaran dengan outing class dengan memanfaatkan halaman sekolah sebagai lokasi pembelajaran. Metode ini mempunyai beberapa keunggulan, yaitu mendorong siswa untuk belajar lebih aktif dan ikut berperan dalam kegiatan belajar mengajar, menerapkan konsep belajar sambil berekreasi (learning by doing and refreshing), dapat menghilangkan rasa jenuh selama belajar di dalam kelas dan dapat mengembangkan kehidupan demokrasi dalam dunia pendidikan. Adapun masalah yang akan dikaji dalam penelitian ini adalah mengenai efektivitas kegiatan belajar dengan outing class (belajar di luar kelas) untuk meningkatkan hasil belajar PKN Materi mengenal fungsi pancasila sebagai perekat persatuan bangsa siswa Kelas V di SD Negeri Ajung 01 Kecamatan Kalisat Semester Ganjil Tahun Pelajaran 2019-2020 pada pembelajaran PKN. Penelitian ini adalah Penelitian Tindakan Kelas (PTK) yang bertujuan untuk meningkatkan motivasi belajar siswa Kelas V dalam proses pembelajaran PKN Penelitian tindakan ini menggunakan 3 (tiga) siklus. Masing-masing siklus terdiri dari empat tahap, yaitu merencanakan, melakukan tindakan, mengamati dan merefleksi. Keempat fase tersebut merupakan suatu siklus yang digambarkan dengan sebuah spiral penelitian tindakan kelas. Dari hasil penelitian, analisa data dan pengujian hipotesis yang telah penulis laksanakan terhadap siswa Kelas V SD Negeri Ajung 01 Kecamatan Kalisat, dapat diambil kesimpulan bahwa Pembelajaran PKN luar kelas di luar kelas atau halaman sekolah pada pembelajaran PKN mampu meningkatkan hasil belajar siswa materi mengenal fungsi pancasila sebagai perekat persatuan bangsa.
UPAYA PENINGKATAN PENGETAHUAN REMAJA PUTRI TENTANG MENARCHE DI SD PONDOK MELATI
Authors: Elfira Sri Futriani  , Ita Herawati  , Lili Farlikhatun  
Published: July 2021

Pendahuluan: Data dunia sebesar 76,3% dari penduduk remaja didunia menyatakan bahwa populasi remaja putri sebagian besar mengalami stress saat menarche Data lain menunjukan sebanyak 54% remaja putri mengalami rasa cemas saat menarche tidak bisa melakukan aktivitas seperti biasanya dengan teman sebaya. Rata-rata usia menarche di Indonesia adalah 13 tahun, dengan kejadian lebih awal pada usia kurang dari 9 tahun atau lebih lambat sampai usia 17 tahun.. Menarche yang terlalu dini atau terlambat , bisa berakibat pada keadaan psikis remaja tersebut. Remaja yang akan mengalami menarche membutuhkan kesiapan mental yang baik.
Metode: Metode yang digunakan adalah pendidikan kesehatan.
Hasil: Menunjukkan sebagian besar mempunyai pengetahuan cukup (56,7 %) sebelum dilakukan pendidikan kesehatan . Sesudah dilaksanakan pendidikan kesehatan sebagian besar mempunyai pengetahuan baik (53,3 %). Dapat di ketahui rata-rata nilai sebelum dilakukan pendidikan kesehatan (56,8%) dan sesudah dilakukan pendidikan kesehatan (78,1%). Ini menunjukkan terjadi kenaikan sebesar 21,3 %.
Kesimpulan: Kegiatan ini berhasil meningkatkan pengetahuan remaja secara signifikan, hal ini juga dipengaruhi oleh penyuluh, ketertiban dan rasa ingin tahu sasaran dan proses pelaksanaan.
PENYULUHAN DUKUNGAN KESEHATAN JIWA DAN PSIKOSOSIAL (DKJPS) COVID-19 PADA MASYARAKAT KATEGORI “ORANG SEHAT” DI BEKASI SELATAN
Authors: Asep Rusman  , Kusnanto  , Mahyar Suara  
Published: July 2021

Pendahuluan: Mewabahnya virus corona (COVID-19) saat ini, menjadi ancaman dan tantangan besar bagi seluruh negara di dunia, termasuk Indonesia. Berbagai upaya telah dilakukan oleh pemerintah namun belum menunjukkan penurunan jumlah kasus. Hal ini menimbulkan masalah baru (stressor) bagi masyarakat salah satunya adalah masalah psikologis. Beredarnya informasi yang tidak adekuat (hoax), kesulitan berinteraksi sosial, masalah ekonomi, ketidakpastian akan berakhirnya masa pandemi dan lainnya membuat masyarakat menjadi mudah khawatir, panik, khawatir, cemas, gelisah, stres, tertekan, takut dan berbagai masalah psikologis lainnya
Metode: Metode yang digunakan dengan empat tahap yaitu tahap persiapan, tahap pelaksanaan, tahap evaluasi, dan tahap lanjutan
Hasil: Terdapat peningkatan pengetahuan yang sangat signifikan tentang pengetahuan dan kemampuan melakukan relaksasi akibat covid-19 pada seluruh peserta penyuluhan
Kesimpulan: Seluruh peserta penyuluhan mampu memahami pengertian, tujuan, manfaat dari kegiatan penkes dan mampu mengaplikasikan cara mengatasi ansietas dan mempertahankan edukasi tersebut pada tindakan sehari-hari sehingga terjadi peningkatan pengetahuan dan sikap yang signifikan