bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perfluoro-N-Octane (PFO) in the Repair of Complicated Retinal Detachments Due to Severe Proliferative Diabetic Retinopathy
Authors: Maturi Raj K , Merrill Pauline T , Lomeo Mark D , Diaz-Rohena Roberto , Khan Myrna , Lambert H Michael 
Published: April 2021

* PURPOSE: To report our experience with perfluoro-N-octane (PFO) in the surgical management of complicated retinal detachments due to proliferative diabetic retinopathy.
* METHODS: Retrospective review of 18 consecutive eyes of 18 patients with tractional or combined tractional and rhegmatogenous retinal detachments due to severe proliferative diabetic retinopathy managed by pars plana vitrectomy and the intraoperative use of PFO. Preoperative characteristics, intraoperative findings and procedures and postoperative results were recorded.
* RESULTS: The mean preoperative acuity was 2/200 (range, 20/25 to light perception). The mean final visual acuity was 4/200 (range, 20/20 to no light perception). With a mean follow-up of 6 months, there was an 89% anatomic reattachment rate at the last visit and visual acuity was stable or improved in 72% of eyes.
* CONCLUSIONS: In our experience, PFO is a helpful surgical adjunct in the anatomic reattachment of tractional or combined tractional and rhegmatogenous diabetic retinal detachments. Visual acuity was stabilized or improved in the majority of eyes.
[Ophthalmic Surg Lasers 1999;30:715-720.]
Follow-Up Appointment Delay in Diabetic Macular Edema Patients
Authors: Agarwal Daniel , Udeh Belinda , Campbell Jack , Bena James , Rachitskaya Aleksandra 
Published: April 2021

BACKGROUND AND OBJECTIVE:
To evaluate a novel measure of compliance, follow-up appointment delay, and assess its relationship with clinical and sociodemographic factors in patients undergoing treatment for diabetic macular edema (DME).

PATIENTS AND METHODS:
This is a comparative case series of patients treated for DME. The novel measure of compliance — the time in days from the intended day of return and actual day of return, or follow-up appointment delay — was studied and compared to a traditional measure: the percentage of visits missed. These were correlated with clinical and sociodemographic characteristics: best-corrected visual acuity, hemoglobin A1C percent (HbA1c), median household income, smoking status, type of insurance held, marital status, gender, and age. Univariate and multivariable analyses were conducted.

RESULTS:
One hundred fifty-five patients (212 eyes) were included in the study. The median times between recommended and actual appointments was 5.0 days (range: 2.0–14.0 days). The mean percentage of visits missed was 31.7% (± 13.3%). The two measures of compliance were positively associated, but the correlation was moderate (r = 0.44). Non-white race, lack of bilateral injections, and higher baseline HBA1c were significant predictors of a median time greater than 7 days between the intended and actual follow-up dates.

CONCLUSIONS:
The current study identified a novel method of measuring compliance of DME patients seen by retina specialists and has identified non-white race, lack for bilateral treatment, and poorer glycemic control as risk factors for noncompliance.

[
Ophthalmic Surg Lasers Imaging Retina.
2021;52:200–206.]
Macular Cone Abnormalities in Behçet's Disease Detected by Adaptive Optics Scanning Light Ophthalmoscope
Authors: Kadomoto Shin , Uji Akihito , Arichika Shigeta , Muraoka Yuki , Kido Ai , Nishijima Kazuaki , Akagi Tadamichi , Kawai Kentaro , Tsujikawa Akitaka 
Published: April 2021

BACKGROUND AND OBJECTIVE:
Investigations of morphological changes in photoreceptors in Behçet's disease (BD) using adaptive optics scanning light ophthalmoscope (AOSLO) are lacking. The authors aimed to evaluate macular cone density and regularity in BD patients with or without a history of uveitis with good visual acuity (VA).

PATIENTS AND METHODS:

The authors included 16 patients (29 eyes) with BD and 12 healthy volunteers (12 eyes) as controls. All subjects had VA of 20/20 or higher. Subjects underwent AOSLO to evaluate the photoreceptor status including cone density (numbers/mm
2
) and proportion of hexagonal Voronoi domains.

RESULTS:

Hyporeflective patches that were not detected in color fundus photograph or optical coherence tomography were observed by AOSLO in BD patients both with and without past uveitis history; these were not detected in the control group. Cone density was significantly reduced in BD patients with a history of uveitis compared to controls (
P
= .002). The proportion of hexagonal Voronoi domains was significantly reduced in BD eyes both with and without history of uveitis relative to controls (
P
< .001).

CONCLUSION:
Macular photoreceptor damage was observed in BD patients with and without a history of uveitis.

[
Ophthalmic Surg Lasers Imaging Retina
. 2021;52:218–225.]
Tuberculosis Treatment Outcome and Associated Factors among Tuberculosis Patients at Wolayta Sodo Teaching and Referral Hospital, Southern Ethiopia: A Retrospective Study
Authors: Teferi Malese Yeshambaw , Didana Lukas Dingato , Hailu Tsegaye , Woldesenbet Simon Genet , Bekele Senedu , Mihret Adane 
Published: April 2021

Background Tuberculosis is a major public health problem throughout the world particularly in resource limited countries. Measuring and reporting of TB treatment outcomes and identifying associated factors are fundamental part of TB treatment. The aim of this study was to assess TB treatment outcome and associated factors among TB patients in Wolayta Sodo Teaching and Referral Hospital, Southern Ethiopia. Design and Method Facility based retrospective cohort study was conducted in Wolayta Sodo Teaching and Referral Hospital. All TB patients who registered during September 2014 to August 2019 and had known treatment outcome were included in the study. The data were collected using pretested structured data extraction format that included demographic, clinical and treatment outcome variables. SPSS Version 23 for windows was used for data processing. Bivariate and multivariate analysis with 95% confidence interval (CI) was employed to infer associations between the independent and dependent variables. Results Of total 232 TB patients included in the study, 54.3% were male, 80.2% were urban residents, 65.9% were pulmonary TB (PTB). From the total 153 PTB cases, 31.5% were smear positive, 17.2% were HIV co-infected and all of them were on antiretroviral treatment. Most, 97.0% of the TB cases were newly diagnosed and all were treated as first line treatment category. The overall treatment success rate was 82.5% (28% cured 54.3% completed), 11.2% loss to follow-up, 4.7% dead and 0.9% treatment failure. The treatment success rate of HIV co-infected TB patients was 77.5%. There was no significant association between TB treatment outcome and age, sex, residence, type of TB, category of patients and HIV status. Conclusion The treatment success rate was low (82.5%) which is below the 90% threshold defined standard with high proportion of patient's lost to follow-up (11.2%). A higher number of transfer-out cases were recorded in this study. Thus, supervision and monitoring of DOTs implementation, improved counseling service, mechanisms for lost to follow-up patients should be strengthen. Establish efficient referral and contact tracing mechanisms for transferred-out cases and document their treatment outcomes of status is also fundamental.
Pengaruh Pengaruh Faktor-Faktor Budaya Organisasi Terhadap Kepuasan Kerja Pegawai Pada Kantor Pemerintah Daerah Kabupaten Karimun
Authors: Sambuardi Roli , Haqiqi Fauzan , Azmi  
Published: April 2021

Abstrak
Penelitian ini dilaksanakan dengan obyek Kantor Pemerintah Daerah Kabupaten Karimun, dengan melibatkan responden yang merupakan pegawai pada Kantor Pemerintah Daerah Kabupaten Karimun yang berjumlah 37 orang. Tujuan penelitian ini adalah untuk menganalisis pengaruh nilai-nilai budaya organisasi baik secara simultan maupun parsial terhadap tingkat kepuasan kerja pegawai Kantor Pemerintah Daerah Kabupaten Karimun. Disamping itu terdapat variabel yang paling dominan berpengaruh terhadap kepuasan kerja pegawai. Variabel dalam penelitian ini meliputi delapan variabel bebas yang terdiri dari Asas Tujuan, Asas Keunggulan, Asas Konsensus, Asas Kesatuan, Asas Prestasi, Asas Empirisme, Asas Keakraban, Asas Integritas, Serta satu variabel terikat yaitu kepuasan kerja pegawai. Pengujian hipotesis menghasilkan bahwa asas integritas mempunyai pengaruh yang paling dominan terhadap kepuasan kerja Pegawai Kantor Pemerintah Daerah Kabupaten Karimun. Hal ini ditunjukkan dengan nilai thitung adalah sebesar 6.521 dengan tingkat signifikansi sebesar 0.000 lebih besar dari ttabel sebesar 2.045. Hal ini menunjukkan bahwa terjadi penolakan Ho dan penerimaan Ha yang berarti terdapat pengaruh yang signifikan variabel asas integritas terhadap variabel kepuasan kerja Pegawai Kantor Pemerintah Daerah Kabupaten Karimun (Y). Nilai thitung ini dinyatakan paling besar dibandingkan variabel-variabel yang lain.
Kata Kunci: Budaya Organisasi, Kepuasan Kerja
Abstract
This research was conducted with the object of the Regional Government Office of Karimun Regency, involving respondents who were employees of the Regional Government Office of Karimun Regency, amounting to 37 people. The purpose of this study was to analyze the effect of organizational culture values ​​both simultaneously and partially on the level of job satisfaction of employees of the Regional Government Office of Karimun Regency. Besides that, there is the most dominant variable influencing employee job satisfaction. The variables in this study include eight independent variables consisting of the Principle of Purpose, Principle of Excellence, Principle of Consensus, Principle of Unity, Principle of Achievement, Principle of Empiricism, Principle of Familiarity, Principle of Integrity, and one dependent variable namely employee job satisfaction. Hypothesis testing results in that the principle of integrity has the most dominant influence on job satisfaction of Karimun Regency Government Office Employees. This is indicated by the tcount value of 6,521 with a significance level of 0,000 greater than the table of 2,045. This shows that there is a rejection of Ho and Ha acceptance, which means there is a significant influence of the integrity principle variable on the job satisfaction variable of the Employees of the Regional Government Office of Karimun Regency (Y). This t-count value is stated to be the largest compared to the other variables.

Keywords: Organizational Culture, Job Satisfaction
Inkonsistensi Tentang Pemberhentian Kepala Negara Menurut Konstitusi Indonesia
Authors: Akbar Aryo 
Published: April 2021

Demokrasi dalam sebuah negara dapat di artikan bahwa seluruh kekuasaan dan kewenangannya harus berdasarkan sebuah aturan yang di sepakati bersama yang di cantumkan dalam sebuah konstitusi negara. Bangsa ketika melaksanakan demokrasi tentu bertujuan untuk menggerakkan roda kekuasaan. Salah satu faktor penyebab orang menjadi peminpin adalah guna menjalankan kekuasaan dalam sebuah negara tersebut harus didasarkan pada keinginan rakyat dalam negara tersebut. Hal tersebut juga terjadi terhadap seorang Presiden yang dipilih oleh rakyat. Presiden merupakan orang yang diberikan kewenanagan dalam menjalankan roda pemerintahan berdasarkan atas keinginan rakyat. Kewenangan dalam menjalankan roda pemerintahan ini diberikan pada bidang eksekutif dan harus di pertanggumgjawabkan pada Parlemen atau bidang Legislatif yang mana parlemen tersebut merupakan representatif dari rakyat. Tata cara/mekanisme pemberhentian presiden setelah amandemen di atur dalam pasal 7A dan 7B Undang-undang Dasar 1945 yang melibatkan sebuah peradilan yakni Mahkamah Konstitusi berdasarkan pada pasal 24 C ayat 2 pada konstitusi Indonesia. Mahkamah Konstitusi yang bagi beberapa ahli juga berpendapat sebagai peradilan politik tentu saja dalam menjalankan tugasnya tentu saja tidak lepas dari pengaruh dinamika politik yang berkembang pada saat itu. Memberhentikan presiden/wakil presiden bukanlah sebuah perkara mudah, Mahkamah Konstitusi harus mendapatkan laporan dan usulan dari Dewan Perwakilan Rakyat (legislatif) sebagai penerjemahan prinsip “check and balance system”. Dukungan politik tentu sangat berpengaruh terhadap pemberhentian kepala negara. Unsur politik lebih berpengaruh dibandingkan putusan yang diberikan oleh mahkamah konstitusi terhadap pelanggaran hukum yang dilakukan kepala negara dalam menjalankan roda pemerintahan yang dibuktikan melalui pemeriksaan yang dilakukan Mahkamah Konstitusi dan dituangkan dalam bentuk putusan. Tidak ada ketentuan dalam konstitusi mewajibkan MPR untuk melakukan putusan yang telah dilakukan lembaga mahkamah konstitusi mengenai pemberhentian terhadap kepala negara tidak memiliki akibat hukum atau sanksi sehingga tidak dilaksanakannya putusan yang dibuat Mahkamah Konstitusi akan menimbulkan ketidakpastian hukum bila tidak dilaksanakan oleh Majelis Permusyawaratan Rakyat selaku eksekutor dari putusan Mahkamah Konstitusi. Idealnya seharusnya putusan yang dibuat atau dikeluarkan oleh Mahkamah Konstitusi harus segera dijalankan dengan dibawa kesidang istimewa guna menjalankan putusan Mahkamah Konstitusi tanpa melakukan voting lagi. Bila voting dilakukan otomatis jika suara terbanyak tidak menerima putusan yang dibuat Mahkamah Konstitusi maka pemberhentian Kepala Negara mengalami jalan buntu
EL RECURSO DE CASACIÓN EN LA JURISDICCIÓN CONTENCIOSO-ADMINISTRATIVA TRAS LA LEY ORGÁNICA 7/2015
Authors: RAZQUIN LIZARRAGA JOSÉ ANTONIO 
Published: April 2021

Este trabajo estudia la reforma del recurso de casación en el orden jurisdiccional contencioso-administrativo operada por la Ley Orgánica 7/2015 de modificación de la Ley Orgánica del Poder Judicial, que establece un nuevo modelo de casación universal cuya clave es la admisión del recurso mediante la apreciación discrecional de la existencia de interés casacional objetivo por la Sala Tercera del Tribunal Supremo.
L lan honetan administrazioarekiko auzien jurisdikzioan kasazio- errekurtsoaren erreformak eragin duen aldaketa aztertzen da. Botere Judizialaren Lege Organikoa aldatzeko 7/2015 Lege Organikoak ekarri du aldaketa hori, eta kasazio-eredu unibertsal berri bat ezartzen du. Horren gakoa da errekurtsoak onartzeko Auzitegi Gorenaren Hirugarren Aretoak kasazio-interes objektiboa hauteman beharko duela, bere eskumenez, errekurtsoa onartzeko.
this paper studies the reform of the cassation appeal in the contentious-administrative jurisdiction operated by the Organic Law 7/2015 amending the Organic Law of the Judiciary Power, establishing a new model of cassation appeal with the transformation of admissibility by discretion of Supreme Court.
Promotion at Canadian Universities: The Intersection of Gender, Discipline, and Institution
Authors: Ornstein Michael , Stewart Penni , Drakich Janice 
Published: April 2021

Statistics Canada’s annual census of full-time faculty at all Canadian universities, between 1984 to 1999, is used to measure the effect of gender, discipline, and institution on promotion from assistant to associate professor and from associate to full professor. Accelerated failure time models show that gender has some effect on rates of promotion, but that disciplinary and institutional variation are much greater. Generally, departments in science, engineering, and professional schools promote their faculty more rapidly, while disciplines strongly oriented to training practitioners are slowest. There is considerable variationamong institutions, but this is not strongly linked to institutional characteristics such as size and prestige. All these factors more strongly affect the length of time for promotion from associate to full professor, than for promotion from assistant to associate professor.
Nous utilisons le recensement annuel des professeures et professeurs à temps plein des universités canadiennes de Statistiques Canada (1984 à 1999) afi n de mesurer la variation du temps nécessaire à la promotion (d’adjoint à agrégé puis d’agrégé à titulaire) en fonction du sexe, de la discipline et de l’institution. Des modèles statistiques (accelerated failure time models) démontrent que le sexe a un léger effet sur la vitesse de la promotion mais que cet effet est moindre que celui de la discipline et de l’institution. Règle générale, les départements de sciences et de génie ainsi que les écoles professionnelles (médecine, droit, etc.) promeuvent plus rapidement leurs professeurs, tandis que les domaines de formation pratique (soins infi rmiers, travail social, etc.) sont plus lents. La variation entre institutions est considérable mais n’est associée ni à leur taille, ni à leur prestige. Ces deux facteurs affectent davantage la vitesse de promotion du rang de professeur adjoint à celui de professeur agrégé que la titularisation.
Determinação do perigo de inundação a partir do mapeamento geomorfológico de detalhe
Authors: Valdati Jairo , Ferreira Daner Rosskamp , Villaça Gomes Maria Carolina 
Published: April 2021

Este trabalho tem por objetivo determinar as áreas sucetíveis às inundações com base em mapeamento geomorfológico em escala de detalhe de uma área sujeita aos diferentes tipos de inundações na planície aluvial de uma bacia hidrográfica com sistema de canais entrelaçados. A área em estudo faz parte da bacia hidrográfica do Rio da Pedra, situada no extremo sul do Estado de Santa Catarina, no município de Jacinto Machado. Para o mapeamento das áreas sujeitas à inundação partiu-se da elaboração do mapeamento geomorfológico de detalhe, elaborado a partir de fotointerpretação e levantamentos de campo. Com base no mapeamento geomorfológico de detalhe, foi confeccionado o mapa das áreas de suscetibilidade à inundação, em escala de detalhe: 1: 25.000. Foram identificados e mapeados 4 níveis de perigo de inundação na planície aluvial do Rio da Pedra: perigo muito alto, alto1, alto 2, médio e sem perigo de inundação.
Natural and natural-like polyphenol compounds: in vitro antioxidant activity and potential for therapeutic application
Authors: Brboric Jasmina , Klisic Aleksandra , Kotur-Stevuljevic Jelena , Delogu Giovanna , Gjorgieva Ackova Darinka , Kostic Kristina , Antonietta Dettori Maria , Fabbri Davide , Carta Paola , Saso Luciano 
Published: April 2021

IntroductionPhenols are a large family of natural and synthetic compounds with known antioxidant activity. The aim of this study was to preform an in vitro screening of natural and natural-like phenol monomers and their C2-symetric dimers (hydroxylated biphenyls) in order to identify those representatives which pharmacophores have the strongest antioxidant and the lowest prooxidant activity.Material and methodsAntioxidative properties of 36 compounds (monomers and their C2-symmetric dimers) were evaluated in vitro. Different (red/ox) assays were used to measure their total oxidative potential (TOP), their total antioxidative capacity (TAC), the pro-oxidative-antioxidant balance (PAB) and total SH-group content (SHG) in a biologically relevant environment. The Pro-oxidative Score, Antioxidative Score and the Oxy Score were also calculated. Trolox, a water soluble analogue of α-tocopherol was used as a positive control.ResultsIn an assay consisting of pooled human serum 6 of the 36 compounds indicated significant antioxidant activity (compounds 6, 7, 12, 13, 26, and 27) whereas 4 indicated extremely weak antioxidant activity (compounds 2, 29, 30, and 31). Within the 36 compounds comprising of zingerone, dehydrozingerone, aurone, chalcone, magnolol derivatives, in both monomeric and dimeric forms, the 2 compounds that indicated the highest antioxidant activity were dehydrozingerone derivatives (compounds 6 and 12). Trolox’s activity was found between the strong and weak antioxidant compounds analysed in our study.ConclusionsIn this study selected dehydrozingerones were identified as good candidates for in-depth testing of their biological behaviour and for possible precursors for the synthesis of novel polyphenolic molecules with potential therapeutic applications.
Influenza in COVID-19 pandemic, epidemiological characteristics, approaches to vaccination
Authors: Краснова Е.И. , Карпович Г.С. , Проворова В.В. , Шестаков А.Е. , Казакова Ю.В. 
Published: April 2021

Грипп – острая высококонтагиозная респираторная инфекция, вызываемая преимущественно вирусами гриппа А, В и С. Грипп имеет особое значение среди других инфекционных болезней в связи с высокой вирулентностью возбудителя, способностью к пандемическому распространению. Однако на современном этапе регистрируются серьезнейшие изменения в эпидемическом процессе гриппа. Ведущее значение в этих процессах принадлежит продолжающейся пандемии COVID-19, а также иным мероприятиям, напрямую связанным с указанной пандемией. В приведенной статье освещается современная эпидемиологическая характеристика гриппозной инфекции в период пандемии COVID-19, рассматриваются вероятные причины развития подобных изменений, подходы к вакцинации от гриппозной инфекции. Массовая иммунизация против гриппа, внедряемая по рекомендациям ВОЗ, продемонстрировала убедительные результаты: применение гриппозных вакцин позволило снизить риск заболеваемости здорового населения на 70-90%. Более того, вакцинация пожилых людей уменьшает количество тяжелых заболеваний и осложнений на 60% и случаев смерти – на 80%. Данный метод борьбы с гриппом приоритетен и в России.
Influenza is an acute highly contagious respiratory infection, caused mainly by influenza A, B and C viruses. Influenza is of particular importance among other infectious diseases, due to the high virulence of the pathogen, widespread distribution, and the ability to spread pandemic. However, at the present stage, serious changes are registered in the epidemic process of influenza. The leading in these processes undoubtedly belongs to the ongoing COVID-19 pandemic, as well as to other events directly related to this pandemic. This article highlights the current epidemiological characteristics of influenza infection during the COVID-19 pandemic, and considers the likely reasons for the development of such changes. Mass immunization against influenza, introduced according to WHO recommendations, has demonstrated convincing results: the use of influenza vaccines has reduced the risk of morbidity in healthy populations by 70-90%. Moreover, vaccination of the elderly reduces the number of serious illnesses and complications by 60% and deaths by 80%. This method of fighting influenza is also a priority in Russia.