bluuebunny/crossref_metadata_2025_split huggingface dataset:
TMS entrains occipital alpha activity: Individual alpha frequency predicts the strength of entrained phase-locking
Authors: Lin Yong-Jun , Shukla Lavanya , Dugué Laura , Valero-Cabré Antoni , Carrasco Marisa 
Published: June 2021

Abstract
Parieto-occipital alpha rhythms (8–12 Hz) underlie cortical excitability and influence visual performance. Whether the synchrony of intrinsic alpha rhythms in the occipital cortex can be entrained by transcranial magnetic stimulation (TMS) is an open question. We applied 4-pulse, 10-Hz rhythmic TMS to entrain intrinsic alpha oscillators targeting right V1/V2, and tested four predictions with concurrent electroencephalogram (EEG): (1) progressive enhancement of entrainment across time windows, (2) output frequency specificity, (3) dependence on the intrinsic oscillation phase, and (4) input frequency specificity to individual alpha frequency (IAF) in the neural signatures. Two control conditions with an equal number of pulses and duration were arrhythmic-active and rhythmic-sham stimulation. The results confirmed the first three predictions. Rhythmic TMS bursts significantly entrained local neural activity. Near the stimulation site, evoked oscillation amplitude and inter-trial phase coherence (ITPC) were increased for 2 and 3 cycles, respectively, after the last TMS pulse. Critically, ITPC following entrainment positively correlated with IAF rather than with the degree of similarity between IAF and the input frequency (10 Hz). Thus, we entrained alpha-band activity in occipital cortex for ~ 3 cycles (~ 300 ms), and IAF predicts the strength of entrained occipital alpha phase synchrony indexed by ITPC.
Title: Supercomplex formed by the cross-binding of multiple antibody-single repeat chain complex gives signal amplification of antibody based assay
Authors: Lee Yongchan , Kim SunMin , Park Jongchan , Choe MuHyeon 
Published: June 2021

Abstract
It is a challenging subject of biomedical research to develop more efficient and sensitive assay method. New method for enhancing sensitivity and precision of conventional immunological assays is developed. The antibody binding domain of Streptococcus protein G was used to make a chain of repeated antibody binding domain. The repeat chain was mixed with antibody, and multiple number of antibody bound to the repeat chain to form multiple antibody-repeat chain complex. The cross-binding between the complexes formed supercomplex, and the supercomplex amplified signals without specificity loss and background noise increase.
Dynamical Gravity, Expanding Space and Stretching Gedesics
Authors: Redwood Clive Anthony 
Published: June 2021

Abstract
The gravitational natures of phenomena separately attributed to dark matter and dark energy and challenges encountered in identifying such sources motivate enquiry into the capabilities of the field, itself, to generate such phenomena. It is found that, in curvature-free Friedmann-Lemaître-Robertson-Walker and gravitationally perturbed Robertson-Walker spacetimes, gravity has an equation of state parameter w = -1 and negative pressures. Expanding space is proposed as the form of a growing cosmic gravitational field. The gravitational-spatial expansion is locally isobaric. Barotropic gravitational dynamics yield the Hubble-Lemaître law. The expansion results from the induction of gravity by matter, radiation and by itself. Gravitational auto-induction is a dynamical feedback process that produces an isotropic spatial expansion with an invariant Hubble parameter like a ‘cosmological constant’ of density 2H2/κ or, equivalently, of a density parameter of 2/3. The Planck 2018 result is moderately higher at about the 2.5/σ level. A new expression of the Hubble parameter in the late homogeneous universe is obtained. The growth of the field isotropically stretches geodesics. In homogeneous regions, this manifests as the Hubble acceleration of bodies and the redshifting of radiation attributed to dark energy. Geodesics may depend on gravitational energy density that retains its values at comoving locations. In inhomogeneous regions, such retentions lead to similar retentions of circular speeds and deflection angles - geodesic stretching - attributed to clustering dark matter. The baryonic Tully-Fisher relation is explained. Dependence of geodesics on gravitational energy explains tidal interactions as being inertial gravitational processes.
Community-Based Group Physical Activity and/or Nutrition Interventions to Promote Health and Mobility in Older Adults: An Umbrella Review
Authors: Neil-Sztramko Sarah E , Teggart Kylie , Moore Caroline , Sherifali Diana , Fitzpatrick-Lewis Donna , Coletta Giulia , Phillips Stuart , Newbold K Bruce , Alvarez Elizabeth , Kuspinar Ayse , Kennedy Courtney C , Santaguida Pasqualina , Ganann Rebecca 
Published: June 2021

Abstract
Background

Physical activity and a healthy diet are important in helping to maintain mobility and quality of life with aging. Delivery of physical activity and nutrition interventions in a group setting adds the benefits of social participation.
Objectives

This umbrella review aims to identify group-based physical activity and nutrition interventions for community-dwelling older adults that improve mobility.
Methods

Five electronic databases (MEDLINE, Embase, CINAHL, Cochrane CENTRAL, Sociological Abstracts) were searched from inception to April 28, 2020. Eligibility criteria included systematic reviews exploring the effectiveness of physical activity and/or nutrition interventions, delivered in a group setting for community-dwelling older adults. Two reviewers independently performed eligibility screening, critical appraisal (using AMSTAR 2) and data extraction. Older adult/provider research partners informed data synthesis and results presentation.
Results

In total, 54 systematic reviews (1 high, 21 moderate, 32 low/critically low quality) were identified; 46 included physical activity only, and eight included both physical activity and nutritional supplements. No reviews included nutrition interventions alone. Combined aerobic/resistance, general physical activity, and mind-body exercise all improved physical function and balance (moderate-high certainty). Aerobic/resistance training improved aerobic capacity (high certainty). Resistance training and general physical activity improved muscle strength (moderate certainty). Aerobic/resistance training and general physical activity are likely to reduce falls among older adults (moderate certainty). There was no evidence of benefit for nutritional supplementation with physical activity.
Conclusions

Multicomponent group-based physical activity interventions can improve measures of mobility in community-dwelling older adults. We found no reviews focused on nutrition only, highlighting a gap in the literature.
Geographic footprints of life expectancy inequalities in the state of Geneva, Switzerland
Authors: Ladoy Anaïs , Vallarta-Robledo Juan , De Ridder David , Sandoval José , Stringhini Silvia , DaCosta Henrique , Guessous Idris , Joost Stéphane 
Published: June 2021

Abstract
Introduction Although Switzerland has one of the highest life expectancy in the world, this global indicator may mask significant disparities at a local level. The present study used a spatial cluster detection approach on individual mortality data to investigate the geographic footprint of life expectancy inequalities in the state of Geneva, Switzerland. Methods Individual-level mortality data (n=30,592) were obtained from the Geneva’s mortuary announcements (2003-2017). We measured life expectancy inequalities through Life Expectancy Difference (LED), defined as the difference between the individual’s age at death and their Life Expectancy at Birth. We assessed the spatial dependence of LED across the state of Geneva using spatial autocorrelation statistics (Local Moran’s I). To ensure the robustness of the discovered patterns, we ran the analysis for ten random subsets of 10,000 individuals drawn from the 30,592 deceased. We also repeated the spatial analysis for LED before and after controlling for nationality and neighborhood income.Results LED was not randomly distributed across the state of Geneva. The ten random subsets revealed no significant difference in the geographic footprint of LED and the population characteristics within Local Moran cluster types, suggesting the robustness of the spatial structure obtained. The proportion of women, the proportion of Swiss, and the median neighborhood income were significantly lower for populations within low LED clusters than for populations within high LED clusters. After controlling for nationality and neighborhood income, we observed a slight reduction in the low LED cluster footprints, but we found similar differences in population characteristics between cluster types.Conclusion To the best of our knowledge, this is the first study in Switzerland using spatial cluster detection methods to investigate small area inequalities in life expectancy. We identified a clear geographic footprint of LED, which may support further investigations and guide future public health interventions at the local level.
A Systematic Study of PPLN Length Dependence in Intracavity SHG
Authors: Kashak Tyler , Flannigan Liam , Xu Chang-qing 
Published: June 2021

Abstract
In this paper, a systematic study of the relationship between nonlinear crystal length and intracavity second-harmonic generation (SHG) using MgO-doped periodically-poled lithium niobate (MgO:PPLN) is presented. The experimental results demonstrate a relationship between the maximum SHG power generated and the full-width at half maximum (FWHM) of the crystal’s temperature tuning curve to the length of the nonlinear optical crystal. It was shown that maximum SHG power increases rapidly with the increase of MgO:PPLN length, reaching a saturation length (~2 mm), which is much shorter than that predicted by the single-pass SHG theory. This saturation length of the MgO:PPLN crystal is almost independent on 808 nm pump power for typical powers used in continuous wave intracavity SHG lasers. In addition to this saturation effect, a broadening effect was also observed, the FWHM of the temperature tuning curve was shown to have a larger FWHM than that predicted by the single-pass SHG theory for MgO:PPLN shorter than the saturation length. This work has the benefit of allowing engineers to optimize nonlinear crystal length when developing intracavity SHG based diode-pumped solid state (DPSS) lasers.
A Case Study on TBM Cutterhead Temperature Monitoring and Mud Cake Formation Discrimination Method
Authors: Fu Jie , Xia Yimin , Lan Hao , Wu Dun , lin Laikuang 
Published: June 2021

Abstract
The mud cake is easily formed during the tunnel boring machine (TBM) excavation in clay soils or rocks containing clay minerals. Mud cake will lead to soil disturbance, clogging cutterhead and even affect the construction efficiency and personnel safety. In this study, a mud cake formation discrimination method based on cutterhead temperature was proposed. An online monitoring system was designed and installed on the slurry shield TBM. The results show that: (a) the cutterhead temperature data can be reliably detected and transmitted by the system; (b) in a tunneling ring, the temperature at some positions of the cutterhead will increase first and then decrease; (c) during the field test, the temperature variation is around 2.5℃ under the normal condition, but the temperature variation will increase more than 50℃ due to the mud cake or geological change; (d) compared with the cooling rate, mud cake formation can be accurately discriminated.
Self-remedied Nanomedicine for Surmounting the Achilles's Heel of Photodynamic Tumor Therapy
Authors: Zhou Xiang , Huang Jia-Qi , Liu Ling-Shan , Deng Fu-An , Liu Yi-Bin , Li Yan-Mei , Chen A-Li , Yu Xi-Yong , Li Shi-Ying , Cheng Hong 
Published: June 2021

Abstract
Background: Photodynamic therapy (PDT) has been recognized as a promising tumor treatment for its minimal invasiveness, low side effects and on-demand light controllability. However, the oxygen-dependent PDT could exacerbate tumor hypoxia to upregulate the expression of hypoxia-inducible factor-1α (HIF-1α), which would promote tumor growth and metastasis. Inhibition of HIF-1α activity is very necessary to PDT for effective tumor suppression.Results: Herein, we developed a self-remedied nanomedicine based on a photosensitizer and a HIF-1α inhibitor to surmount the Achilles' heel of PDT for enhanced antitumor efficacy. Specifically, the nanomedicine (designated as CYC-1) was prepared by the self-assembly of Ce6 and YC-1 through π-π stacking and hydrophobic interactions. Carrier-free CYC-1 held an extremely high drug loading rate, uniform size distribution and favorable stability. Compared with free Ce6, CYC-1 exhibited an improved cellular uptake behavior and an enhanced ROS production capability. Besides, CYC-1 had the overwhelming superiority on restraining tumor proliferation over the combined administration of Ce6 and YC-1. More importantly, CYC-1 preferred to accumulate in tumor tissue for efficient PDT by inhibiting the activity of HIF-1α. Ultimately, this YC-1-assistant PDT effectively restrained the tumor growth and caused a low system toxicity. Conclusions: This carrier-free self-remedied strategy overcame the Achilles' heel of PDT on tumor suppression while induced a minimal side effect, which would expedite the development and clinical translation of nanomedicine for PDT against hypoxic tumors.
Monitoring Inflow Dynamics in a Multipurpose Dam Based on Travel-Time Principle
Authors: Sawaf Mohamad Basel Al , Kawanisi kiyosi , Xiao Cong , Noor Gillang , Khadami Faruq , Gusti Nugrahaning 
Published: June 2021

Abstract
Understanding inflow dynamics in a dam lake forms the basis for optimal dam operation and management practices. However, methods pertaining to adequately determining negative inflows and addressing them, as well as quantifying uncertainties in dam inflow, have been scarcely investigated. In this study, the inflow was observed using two pairs of fluvial acoustic tomography (FAT) systems placed diagonally in a dam lake, forming a crossed-shaped pattern. The “travel-time” principle is the primary approach for measuring the inflow by FAT. The novelty of this study is in discussing the inflow characteristics within a slow water-flow environment monitored by FAT. Based on the reciprocal sound transmission, we upgraded an equation to estimate the flow direction; this newly proposed generalized equation can be used in a fluctuating flow environment. We also discussed the sound propagation characteristics for slow flow velocities. Finally, we demonstrated that a small inaccuracy in the acoustic signal, even by a sub-millisecond, can cause significant errors in measurements. One of the novel findings of this study is the detection of internal waves using the improved flow direction equation and acoustic travel-time records. Overall, this study presents a promising approach for inflow measurements under extremely slow flow conditions.
‘It Was Hell in the Community’: A Qualitative Study of Maternal and Child Health Care During Health Care Worker Strikes in Kenya
Authors: Scanlon Michael L , Maldonado Lauren Y. , Ikemeri Justus E. , Jumah Anjellah , Anusu Getrude , Chelagat Sheilah , Keter Joann Chebet , Songok Julia , Ruhl Laura J. , Christoffersen-Deb Astrid 
Published: June 2021

Abstract
Background: Health care workers in Kenya have launched major strikes in the public health sector in recent years but how strikes by health care workers affect health systems and services is under-explored. We conducted a qualitative study to explore maternal and child health care and services during nationwide strikes by health care workers in 2017 from the perspective of pregnant women, community health volunteers (CHVS), and health facility managers. Methods:We conducted interviews and focus group discussions (FGDs) with three populations: women who were pregnant in 2017, CHVs, and health facility managers. Participants were part of a previous study and recruited using convenience sampling from a single County in western Kenya. Interviews and FGDs were conducted in English or Kiswahili using semi-structured guides that probed women’s pregnancy experiences and maternal and child health services in 2017. Interviews and FGDs were audio-recorded, translated, and transcribed. Content analysis followed a thematic framework approach using deductive and inductive approaches. Data were collected March to July 2019. All participants provided written informed consent.Results:Forty-three women (mean age 28) and 22 CHVs (mean age 47) participated in 4 FGDs and 3 FGDs, respectively, and 8 health facility managers (mean age 38) participated in interviews. CHVs and health facility managers were majority female (80%). Participants reported that strikes by health care workers significantly impacted the availability and quality of maternal and child health services in 2017 and led to indirect economic effects due to households paying for services in the private sector. Participants overwhelmingly felt it was the poor, particularly poor women, who were most affected since they were more likely to rely on public services, while CHVs highlighted their own poor working conditions in response to strikes by other health care workers. Strikes strained relationships and trust between communities and the health system that were identified as particularly important to maternal and child health care. Conclusion: The impacts of strikes by health care workers extend beyond negative health and economic effects and exacerbate fundamental inequities in the health system with important implications for health systems strengthening and universal health coverage in Kenya and other countries.
Prevalence of Hepatitis B virus and its predictors among volunteer blood donors in Jimma, Ethiopia, 2018
Authors: Solomon Tesfaye , Mekonnen Debele , Nigatu Mamo 
Published: June 2021

Abstract
Background: Transfusion of contaminated blood causes a significant burden of Hepatitis B virus (HBV) infection globally and more than 45,000 infections in Sub-Saharan Africa annually. However, very few studies were conducted in Ethiopia to assess the status of HBV. Objective: To determine the prevalence of HBV and its predictors among volunteer blood donors in Jimma Zone, Southwest Ethiopia.Material and Methods: A cross-sectional study was conducted among volunteer blood donors who consecutively included from March 10 - April 20, 2018. The detection of the virus was made through the investigation of the Hepatitis B surface antigen in the serum. Data collected through a structured questionnaire were entered into Epi-data 3.1 and analyzed by SPSS 20. Adjusted Odds Ratio with 95% Confidence Interval computed using multivariable logistic regression and statistical significance established at P<0.05. Results: A total of 548 (98.7%) volunteer blood donors participated. The overall prevalence of HBV infection was 16 (2.92%) with 12 (4.5%) and 4 (1.4%) prevalence among males and females respectively. Male sex [AOR=3.28, 95%CI: 1.01-10.68], age 18-24 years [AOR=0.17, 95%CI: 0.36-0.78], frequency of donation [AOR= 0.25, 95%CI: 0.08-0.76] and exposure to unsafe therapeutic drug injection [AOR= 6.98, 95%CI: 1.66-29.29] were significant factors for HBV infection. Conclusions: The prevalence of HBV in the study area was intermediate. Age, sex, frequency of donation, and exposure to unsafe therapeutic drug injection were independent predictors of HBV. Therefore, the blood bank should focus on blood donation among identified low-risk groups and should strengthen counseling for repeated volunteer blood donors.
Timescales and rates of intrusive and metamorphic processes determined from zircon and garnet in migmatitic granulite, Fiordland, New Zealand
Authors: Stowell Harold , Schwartz Joshua , Bollen Elizabeth , Tulloch Andy , Ramezani Jahandar , Klepeis Keith 
Published: June 2021

Abstract
Zircon U-Pb, and garnet Sm-Nd and Lu-Hf dates provide important constraints on local and orogenic scale processes in lower-crustal rocks. However, in high-temperature metamorphic rocks these isotopic systems typically yield significant ranges reflecting both igneous and metamorphic processes. Therefore, linking dates to specific aspects of rock history can be problematic. In Fiordland, New Zealand, granulite-facies orthogneiss is cut by leucosomes that are bordered by garnet clinopyroxene reaction zones (garnet reaction zones). In both host orthogneiss and garnet reaction zones, zircon are typically anhedral with U-Pb dates ranging from 118.30 ± 0.13 to 115.70 ± 0.18 Ma (CA-ID-TIMS) and 121.4 ± 2.0 to 109.8 ± 1.8 Ma (SHRIMP-RG). Zircon dates in host and garnet reaction zone do not define distinct populations. In addition, the dates cannot be readily grouped based on external morphology or internal CL zoning. Zircon trace-element concentrations indicate two distinct crystallization trends, clearly seen in Th and U. Garnet occurs in selvages to the leucosome veins and in the adjacent garnet reaction zones. In selvages and host orthogneiss, garnet is generally 0.5 to 1 cm diameter and euhedral and is 0.1 to 0.5 cm diameter and subhedral in garnet reaction zones. Garnet Sm-Nd and Lu-Hf dates range from ca. 115 to 101 Ma (including uncertainties) and correlate with grain size. We interpret the CA-ID-TIMS zircon dates to record the age of magma emplacement and the SHRIMP-RG dates to record a range from igneous crystallization to metamorphic dissolution and reprecipitation and/or local Pb loss. Zircon compositional trends within the garnet reaction zone and host are compatible with locally isolated melt and/or separate intrusive magma batches for the two samples described here. Dates for the largest, ~1 cm, garnet of ~113 Ma record growth during metamorphism, while the smaller grains with younger dates reflect high-temperature intracrystalline diffusion and isotopic closure during cooling. The comprehensive geochronological data set for a single location in the Malaspina Pluton illustrates a complex and protracted geologic history common in granulite facies rocks, estimates lower crustal cooling rates of ~20 °C/m.y., and underlines the importance of multiple chronometers and careful textural characterization for assigning meaningful ages to lower-crustal rocks. Numerous data sets from single locations, like the one described here, are needed to evaluate the spatial extent and variation of cooling rates for Fiordland and other lower crustal exposures.