bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of seasonal and longitudinal variation of daytime MSTID activity using GPS observation and GAIA simulations
Authors: Sivakandan Mani , Otsuka Yuichi , Ghosh Priyanka , Shinagawa Hiroyuki , Shinbori Atsuki , Miyoshi Yasunobu 
Published: February 2021

AbstractThe total electron content (TEC) data derived from the GAIA (Ground-to-topside model of Atmosphere Ionosphere for Aeronomy) is used to study the seasonal and longitudinal variation of occurrence of medium-scale traveling ionospheric disturbances (MSTIDs) during daytime (09:00–15:00 LT) for the year 2011 at eight locations in northern and southern hemispheres, and the results are compared with ground-based Global Positioning System (GPS)-TEC. To derive TEC variations caused by MSTIDs from the GAIA (GPS) data, we obtained detrended TEC by subtracting 2-h (1-h) running average from the TEC, and calculated standard deviation of the detrended TEC in 2 h (1 h). MSTID activity was defined as a ratio of the standard deviation to the averaged TEC. Both GAIA simulation and GPS observations data show that daytime MSTID activities in the northern and southern hemisphere (NH and SH) are higher in winter than in other seasons. From the GAIA simulation, the amplitude of the meridional wind variations, which could be representative of gravity waves (GWs), shows two peaks in winter and summer. The winter peak in the amplitude of the meridional wind variations coincides with the winter peak of the daytime MSTIDs, indicating that the high GW activity is responsible for the high MSTID activity. On the other hand, the MSTID activity does not increase in summer. This is because the GWs in the thermosphere propagate poleward in summer, and equatorward in winter, and the equatorward-propagating GWs cause large plasma density perturbations compared to the poleward-propagating GWs. Longitudinal variation of daytime MSTID activity in winter is seen in both hemispheres. The MSTID activity during winter in the NH is higher over Japan than USA, and the MSTID activity during winter in the SH is the highest in South America. In a nutshell, GAIA can successfully reproduce the seasonal and longitudinal variation of the daytime MSTIDs. This study confirms that GWs cause the daytime MSTIDs in GAIA and amplitude and propagation direction of the GWs control the noted seasonal variation. GW activities in the middle and lower atmosphere cause the longitudinal variation.
Comparison of dental caries (DMFT and DMFS indices) between asthmatic patients and control group in Iran: a meta-analysis
Authors: Elyassi Gorji Nadia , Nasiri Pegah , Malekzadeh Shafaroudi Ali , Moosazadeh Mahmood 
Published: February 2021

AbstractBackgroundThe association between caries index, which is diagnosed by Decayed, Missing, and Filled Teeth (DMFT), and asthma has been assessed in several studies, which yielded contradictory results. Meta-analysis is the statistical procedure for combining data from multiple studies and reducing the differences among parameters due to the increased number of studies involved in the analysis process. Therefore, the present study aimed to determine the relationship between dental caries using decayed, missing, filled teeth indices (DMFT, dmft, and DMFS indices) and asthma using meta-analysis.MethodsDatabases were searched using such keywords as “Asthma,” “Caries,” “DMFT,” “DMFS,” “Iran,” and OR operators, AND, and NOT. After the elimination of duplicate documentation, the articles which met the inclusion criteria were selected. Quality assessment was performed based on the Newcastle-Ottawa Quality Checklist (NOS). After that, standardized mean difference (SMD) of DMFT, dmft, and Decayed, Missing, and Filled Surfaces (DMFS) indices were estimated.ResultsThe number of 10 evidence was extracted out of nine studies in which mean oral health indices were compared between asthmatic patients and the control group. Out of 10 evidences that examined the association of DMFT, dmft, and DMFS with asthma, these indices were higher in asthmatic patients than the control group in seven cases. In three cases, these differences were statistically significant. The SMD of DMFT, dmft, and DMFS indices between asthmatic patients and the control group at the confidence level of 95% were reported as 0.29 (− 0.05, 0.62), 0.48 (− 0.20, 1.17), and − 0.05(− 0.30, 0.21), respectively.ConclusionAccording to the results, the prevalence of dental caries is higher among patients with asthma than in the control group. Therefore, having asthma could be considered a risk factor for the development of dental caries.
DEep VEin Lesion OPtimisation (DEVELOP) trial: protocol for a randomised, assessor-blinded feasibility trial of iliac vein intervention for venous leg ulcers
Authors: Aherne Thomas M. , Keohane Colm , Mullins Matthew , Zafar Adeel S. , Black Stephen A. , Tang Tjun Y. , O’Sullivan Gerard J. , Walsh Stewart R. 
Published: February 2021

Abstract
Background
Venous leg ulceration is a widespread, debilitating pathology with high recurrence rates. Conservative treatment using graduated compression dressings may be associated with unacceptable ulcer recurrence rates. Early superficial venous ablation encourages ulcer healing and reduces recurrence. However, many of this cohort display concomitant ilio-caval stenosis, which further contributes to lower limb venous hypertension and ulceration.
An approach that combines early superficial venous ablation with early treatment of ilio-caval stenotic disease may significantly improve ulcer healing and recurrence rates. We question whether early iliac vein interrogation with intravascular ultrasound (IVUS), stenting of significant occlusive disease plus superficial venous ablation, in patients with active venous leg ulceration, will produce superior ulcer healing to standard therapy.

Methods
This is a prospective, multi-centre, randomised controlled, feasibility trial recruiting patients with lower limb venous ulceration and saphenous venous incompetence. Patients will be randomised to undergo either truncal ablation and compression therapy or truncal ablation, simultaneous iliac interrogation with intravascular ultrasound and stenting of significant (> 50%) iliac vein lesions plus compression therapy. The primary feasibility outcome will be the rate of eligible patient participation while the primary clinical outcomes will be ulcer healing and procedural safety. Secondary outcomes include time to healing, quality of life and clinical scores, ulcer recurrence rates and rates of post-thrombotic syndrome. Follow-up will be over a 5-year period. This feasibility trial is designed to include 60 patients. Should it be practicable a total of 594 patients would be required to adequately power the trial to definitively address ulcer-healing rates.

Discussion
This trial will be the first randomised trial to examine the role iliac interrogation and intervention in conjunction with standard operative therapy in the management of venous ulceration related to superficial truncal venous incompetence.

Ethical committee reference
C.A. 2111 Galway Clinical Research Ethics Committee

Registration
Clinical Trials.gov registration NCT03640689, Registered on 21 August 2018.
Identifying the key factors of subsidiary supervision and management using an innovative hybrid architecture in a big data environment
Authors: Hu Kuang-Hua , Hsu Ming-Fu , Chen Fu-Hsiang , Liu Mu-Ziyun 
Published: February 2021

AbstractIn a highly intertwined and connected business environment, globalized layout planning can be an effective way for enterprises to expand their market. Nevertheless, conflicts and contradictions always exist between parent and subsidiary enterprises; if they are in different countries, these conflicts can become especially problematic. Internal control systems for subsidiary supervision and management seem to be particularly important when aiming to align subsidiaries’ decisions with parent enterprises’ strategic intentions, and such systems undoubtedly involve numerous criteria/dimensions. An effective tool is urgently needed to clarify the relevant issues and discern the cause-and-effect relationships among them in these conflicts. Traditional statistical approaches cannot fully explain these situations due to the complexity and invisibility of the criteria/dimensions; thus, the fuzzy rough set theory (FRST), with its superior data exploration ability and impreciseness tolerance, can be considered to adequately address the complexities. Motivated by efficient integrated systems, aggregating multiple dissimilar systems’ outputs and converting them into a consensus result can be useful for realizing outstanding performances. Based on this concept, we insert selected criteria/dimensions via FRST into DEMATEL to identify and analyze the dependency and feedback relations among variables of parent/subsidiary gaps and conflicts. The results present the improvement priorities based on their magnitude of impact, in the following order: organizational control structure, business and financial information system management, major financial management, business strategy management, construction of a management system, and integrated audit management. Managers can consider the potential implications herein when formulating future targeted policies to improve subsidiary supervision and strengthen overall corporate governance.
The protean manifestations of central nervous system IgG4-related hypertrophic pachymeningitis: a report of two cases
Authors: Woo Peter Y. M. , Ng Ben C. F. , Wong June H. M. , Ng Oliver K. S. , Chan Timothy S. K. , Kwok Ngai-Fung , Chan Kwong-Yau 
Published: February 2021

Abstract
Background
IgG4-related hypertrophic pachymeningitis is a relative newly recognized and rare manifestation of IgG4-related disease, an immune-mediated fibroinflammatory tumefactive disorder. Fewer than 80 patients have been reported in the literature, and it can mimic common neurosurgical conditions. We describe the clinical presentation of two patients that were initially considered to have a subdural collection, tuberculous meningitis, and a cervical spinal meningioma, but were eventually diagnosed with this disease.

Case presentation
Two ethnic Chinese men, 86 and 62 years old, experienced a 4-week history of headache. Both patients had a history of autoimmune disease, namely glomerulonephritis and Grave’s disease, respectively. Magnetic resonance brain imaging revealed diffuse dural thickening with the latter patient exhibiting homogeneous and intense gadolinium-contrast enhancement. Since the 86-year-old patient also had progressive bilateral visual loss, giant cell arteritis was suspected and a 2-week course of glucocorticoid therapy was prescribed, but his symptoms failed to improve. The 62-year-old patient also had accompanying low-grade fever and was treated empirically as having tuberculous meningitis although there were no confirmatory microbiological findings. This patient further developed right hemiparesis, and additional imaging revealed a C4/5 intradural-extramedullary contrast-enhancing lesion resembling a meningioma causing cord compression. Both patients underwent neurosurgical intervention with the former undergoing a dural biopsy and the latter having the cervical lesion resected. The final diagnosis was IgG4-related hypertrophic pachymeningitis with the hallmark histological features of lymphoplasmacytic infiltration of IgG4+ plasma cells, storiform fibrosis, and obliterative phlebitis. In addition, their serum IgG4 levels were elevated (i.e., > 135 mg/dL). Both patients received at least 6 months of glucocorticoid therapy while the latter also had azathioprine. Their symptoms improved significantly and recurrent lesions were not detected on follow-up imaging.

Conclusions
A high index of suspicion for this condition is suggested when a male patient with a history of autoimmune disease and compatible radiological findings, experiences subacute headache that is disproportionate to the degree of dural involvement. Neurosurgeons should consider early meningeal biopsy to establish a definitive histological diagnosis in order for early effective immunosuppressive treatment to be initiated and to avoid unnecessary morbidity.
Prescription characteristics of phosphate binders in a high pill burden for hemodialysis patients
Authors: Nagano Nobuo , Ito Kyoko , Ono Takashi , Ariyoshi Yuichi , Masima Soichiro , Kobayashi Hajime , Ando Tetsuo , Tsutsui Takaaki , Ogawa Tetsuya 
Published: February 2021

Abstract
Background
Dialysis patients have to take many oral drugs, causing a high pill burden. Phosphate binders (PBs) account for a large proportion of daily pill burden; however, the relationship between patient background and prescription status of PBs is not clear.

Methods
We clarified the characteristics of PBs in the total daily pill burden by analyzing the drugs prescribed for 533 chronic hemodialysis patients in our facility.

Results
An average of nine different types of oral drugs was prescribed for each patient. The mean and median values of total pill burden were 15.1 and 14.1 pills/day/patient, respectively. The total pill burden showed a significant negative correlation with age and a significant positive correlation with dialysis vintage. In addition, the total pill burden was significantly higher in males than in females. However, there was no difference in the pill burden between patients with and without diabetes mellitus (DM). PBs were prescribed to 409 patients (76.7%), and the mean pill burden derived from PBs was 6.44 pills/day/patient. This was by far the highest of all 35 different drug categories and accounted for 32.84% of all pills. Multiple regression analysis demonstrated that independent predictors of total pill burden were age, dialysis vintage, DM, and serum phosphorus (P) levels, and all these variables, except DM, were also independent predictors of pill burden from PBs. These variables were also selected when considering the use of calcimimetics.

Conclusions
A high pill burden is more likely to occur in younger patients with longer dialysis vintage, DM, higher serum P levels, and prescription of calcimimetics. In addition, PB was the single largest contributor to the total pill burden that positively and linearly linked to serum P levels. Therefore, P management is a high-priority issue in the mitigation of high pill burdens in dialysis patients.
Decapod crustaceans associated with macroinvertebrates in Pacific Costa Rica
Authors: Salas-Moya Carolina , Vargas-Castillo Rita , Alvarado Juan José , Azofeifa-Solano Juan Carlos , Cortés Jorge 
Published: February 2021

AbstractDecapod crustaceans are a diverse group that exploits various types of habitats in Costa Rica, where they represent 8.1% of the marine diversity of the country. This group includes families containing species with strictly symbiotic behavior, e.g., the Palaemonidae and Pinnotheridae. Despite the high diversity of decapods and the importance of symbionts in marine ecosystems, very little research has been done regarding symbiosis in Costa Rica and the Central American region. The objective of the present study is to present a check list of the species of decapods that are associated with macroinvertebrates in Pacific Costa Rica. The research was carried out using different sources, including a literature review, the Crustaceans Collection of the Zoology Museum of the University of Costa Rica, and field surveys between 1970 and 2019 along the Pacific coast of Costa Rica, and Isla del Coco, 500 km offshore. One-hundred associations are reported, of 74 species of symbiotic decapods with six host phyla. Seventy-four associated with Cnidaria, 15 with Echinodermata, four each with Annelida and Mollusca, two with Chordata, and one with Porifera. In total, there were 14 new reports of decapods occurring on Isla del Coco and four new reports of decapods for Costa Rica: Pseudocoutierea elegans, Raytheres clavapedatus, Tuleariocaris holthuisi, and Calyptraeotheres pepeluisi. These results highlight the need to conduct more detailed studies to determine the real diversity and ecological importance of the associations between marine organisms.
A scoping review of causal methods enabling predictions under hypothetical interventions
Authors: Lin Lijing , Sperrin Matthew , Jenkins David A. , Martin Glen P. , Peek Niels 
Published: February 2021

Abstract
Background
The methods with which prediction models are usually developed mean that neither the parameters nor the predictions should be interpreted causally. For many applications, this is perfectly acceptable. However, when prediction models are used to support decision making, there is often a need for predicting outcomes under hypothetical interventions.

Aims
We aimed to identify published methods for developing and validating prediction models that enable risk estimation of outcomes under hypothetical interventions, utilizing causal inference. We aimed to identify the main methodological approaches, their underlying assumptions, targeted estimands, and potential pitfalls and challenges with using the method. Finally, we aimed to highlight unresolved methodological challenges.

Methods
We systematically reviewed literature published by December 2019, considering papers in the health domain that used causal considerations to enable prediction models to be used for predictions under hypothetical interventions. We included both methodologies proposed in statistical/machine learning literature and methodologies used in applied studies.

Results
We identified 4919 papers through database searches and a further 115 papers through manual searches. Of these, 87 papers were retained for full-text screening, of which 13 were selected for inclusion. We found papers from both the statistical and the machine learning literature. Most of the identified methods for causal inference from observational data were based on marginal structural models and g-estimation.

Conclusions
There exist two broad methodological approaches for allowing prediction under hypothetical intervention into clinical prediction models: (1) enriching prediction models derived from observational studies with estimated causal effects from clinical trials and meta-analyses and (2) estimating prediction models and causal effects directly from observational data. These methods require extending to dynamic treatment regimes, and consideration of multiple interventions to operationalise a clinical decision support system. Techniques for validating ‘causal prediction models’ are still in their infancy.
Psychometric properties of a condition-specific PROM for the psychosocial consequences of Labelling hypertension by using Rasch analysis
Authors: Gyuricza János Valery , Christensen Karl Bang , d’Oliveira Ana Flávia Pires Lucas , Brodersen John 
Published: February 2021

AbstractBackgroundA previous qualitative assessment of the psychosocial consequences of labelling hypertension describes the diagnosis of hypertension as a labelling event with potential unintended negative long-term psychosocial consequences (labelling effects). Until now, the benefits of diagnosing hypertension have been far more reported than the harms. To obtain the net result of the preventive interventions for cardiovascular disease, such as diagnosing and treating mild hypertension, assessing benefits and harms in the most comprehensive way possible is necessary, including the psychosocial consequences of labelling. When measuring psychosocial consequences of labelling hypertension, a questionnaire with high content validity and adequate psychometric properties is needed.ObjectivesThe aim of this study was to describe the psychometric parameters of face and content-validated pool of items. Other objectives were also to screen the item pool by using Rasch model analysis and confirmatory factor analysis (CFA) for identifying such items with sufficient fit to the hypothesised models.MethodsWe surveyed the pool of items as a draft questionnaire to Brazilians recruited via social networks, sending e-mails, WhatsApp® messages and posting on Facebook®. The inclusion criteria were to be older than 18 years old, to be healthy and to have only hypertension.We used Rasch model analysis to screen the item pool, discarding items that did not fit the hypothesised domain. We searched for local dependence and differential item functioning. We used CFA to confirm the derived measurement models and complementarily assessed reliability using Cronbach’s coefficient alpha.ResultsThe validation sample consisted of 798 respondents. All 798 respondents completed Part I, whereas 285 (35.7%)—those with hypertension—completed Part II. A condition-specific questionnaire with high content validity and adequate psychometric properties was developed for people labelled with hypertension. This measure is called ‘Consequences of Labelling Hypertension Questionnaire’ and covers the psychosocial consequences of labelling hypertension in two parts, encompassing a total of 71 items in 15 subscales and 11 single items.ConclusionWe developed a tool that can be used in future research involving hypertension, especially in scenarios of screening, prevention, population strategies and in intervention studies. Future use and testing of the questionnaire may still be required.
Outcomes in rheumatoid arthritis patients treated with abatacept: a UK multi-centre observational study
Authors: Choy Ernest , Groves Lara , Sugrue Daniel , Hurst Michael , Houghton John , Venkatachalam Srinivasan , Patel Yusuf I. , Maxwell James R. , Pollock Kevin G. , Henning Sadie 
Published: February 2021

Abstract
Background
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that causes chronic synovitis, resulting in progressive joint destruction and functional disability and affects approximately 400,000 people in the UK. This real-world study aimed to describe the characteristics, treatment patterns and clinical outcomes of patients who received abatacept in UK clinical practice.

Methods
This was a multi-centre, retrospective, observational study of patients with RA treated with abatacept at four UK centres between 01 January 2013 and 31 December 2017. Data were collected from medical records of each patient from the index date (date of first bDMARD initiation) until the most recent visit, death or end of study (31 December 2017).

Results
In total, 213 patients were included in the study. Patients received up to eight lines of therapy (LOTs). Treatment with abatacept, or any other bDMARD, was associated with reductions in DAS28-ESR and DAS28-CRP scores at 6 and 12 months. The distribution of EULAR responses (good/moderate/no response) tended to be more favourable for patients when receiving abatacept than when receiving other bDMARDs (22.8%/41.3%/35.9% versus 16.6%/41.4%/42.1% at 6 months, and 27.9%/36.1%/36.1% versus 21.2%/34.5%/44.2% at 12 months). Patients receiving abatacept at LOT1 (n = 68) spent significantly longer on treatment compared with patients receiving other bDMARDs (53.4 vs. 17.4 months; p< 0.01); a similar trend was observed for LOT2. Among patients who discontinued after 6 months, a greater proportion experienced infection requiring antibiotics when receiving other bDMARDs compared to those receiving abatacept.

Conclusions
RA patients who received bDMARDs, including abatacept, experienced reduced disease activity. When receiving abatacept as first or second line of therapy, patients persisted with treatment significantly longer than those receiving other bDMARDs.