bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Lactobacillus spp. Supplementation in Helicobacter pylori Eradication: A Systematic Meta‐Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Authors: Mishra Vivek , Dash Debabrata , Panda Aditya K. , Pathak Sushil Kumar 
Published: December 2024

ABSTRACTBackgroundHelicobacter pylori infection is a major global health concern and has been associated with a number of gastrointestinal disorders. Probiotics, especially Lactobacillus spp., have been suggested to have beneficial effect in managing H. pylori infection. This meta‐analysis of randomized control trials (RCTs) aimed to evaluate the effect of Lactobacillus spp. supplementation on H. pylori eradication rates and associated side effects when combined with standard therapy.Materials and MethodsRelevant studies were retrieved from PubMed, Scopus, Google Scholar and the Cochrane Library. Comprehensive Meta‐Analysis (CMA) Software 4.0 was used for all the statistical analyses. TSA 0.9.5.10 Beta software was used for the trial sequential analysis (TSA). GRADEpro GDT was used to assess the certainty of evidence.ResultsAn analysis of 26 selected studies showed that supplementing with Lactobacillus spp. significantly increased the rates of H. pylori eradication in per‐protocol (PP) analysis (Overall risk ratio [RR] = 1.063, p = 0.000, 95% CI of −0.21 to 2.11; adults: RR = 1.050, p = 0.005, 95% CI = −0.55 to 2.03, children: RR = 1.223, p = 0.001, 95% CI = −13.35 to 4.55). In comparison to quadruple therapy, Lactobacillus spp. supplementation to triple therapy showed significant benefit (RR: 1.124; p = 0.000, 95% CI of −0.48 to 2.61). L. reuteri supplementation indicated better efficacy (RR: 1.049; p = 0.055, 95% CI of −0.56 to 3.26) than Lactobacillus GG (RR: 0.980; p = 0.595, 95% CI of −0.69 to 1.21). The 28–30 day (RR: 1.103; p = 0.003, 95% CI of −2.14 to 4.19) and 14‐day supplementation periods (RR: 1.102; p = 0.003, 95% CI of −1.69 to 3.51) showed the most improvement. The analysis also revealed that Lactobacillus spp. significantly reduced gastrointestinal side effects: nausea/vomiting (RR: 0.566; p = 0.037, −3.11 to 1.45), diarrhea (RR: 0.324; p = 0.000, −5.46 to 0.48), and abdominal pain (RR: 0.438; p = 0.007, −5.65 to 4.22). The effect on bloating was non‐significant (RR: 0.820; p = 0.498, −4.01 to 0.96). TSA graphs validated sufficient evidence for the conclusions.ConclusionLactobacillus spp. significantly enhances H. pylori eradication rates and may reduce gastrointestinal side effects when used alongside standard therapy, offering a promising adjunctive treatment option. The evidence was supported by TSA and assessed using GRADEpro, indicating a high certainty of the findings.
Evaluating the impact of the Dietary Approaches to Stop Hypertension diet versus a calorie‐restricted diet on metabolic dysfunction‐associated steatotic liver disease: A meta‐analysis of randomized controlled trials
Authors: Hasan Fariha , Singh Avneet , Garcia Alexander , Qadri Syeda Hafsa , Sattar Hina , Ali Rimmel , Ali Hassam , Nguyen Tommy , Mohan Babu P. , Contino Krysta 
Published: December 2024

AbstractAimMetabolic dysfunction‐associated steatotic liver disease (MASLD) can lead to increased morbidity and mortality. Diets high in refined carbohydrates and saturated fats elevate MASLD risk. The Dietary Approaches to Stop Hypertension (DASH) diet has shown metabolic benefits. This meta‐analysis evaluates the impact of the DASH diet on MASLD progression.MethodsA systematic search from 2016 to 2023 across PubMed, Embase, Web of Science, and Cochrane databases was conducted to identify studies reporting on the role of the DASH diet in MASLD. Standard meta‐analysis methods were employed using a random‐effects model. Heterogeneity was assessed by I2 statistics.ResultsWe identified five randomized controlled trials meeting inclusion criteria, involving 280 participants (140 in the DASH group and 140 in the control group). Mean ages were approximately 41 years, and the proportions of women were similar between groups. Compared with controls, the DASH diet group had a significantly reduced risk of grade 0 and 1 liver fibrosis (RR 1.21, 95% CI 1.04–1.41, p = 0.01). They also showed lower levels of aspartate aminotransferase (MD −4.81, 95% CI −6.98 to −2.64, p < 0.0001), alanine aminotransferase (MD −10.31, 95% CI −13.82 to −6.80, p < 0.00001), body mass index (MD −0.74, 95% CI −1.45 to −0.03, p = 0.04), and cholesterol‐to‐high‐density lipoprotein ratio (MD −0.40, 95% CI −0.68 to −0.11, p = 0.006). No significant differences were found for weight, waist and hip circumference, total cholesterol, low‐density lipoprotein, or high‐density lipoprotein levels. Heterogeneity was low for most outcomes (I2 = 0%).ConclusionBased on our meta‐analysis of five randomized controlled trials, the DASH diet may reduce MASLD progression. These findings suggest it could be an effective dietary intervention for MASLD management.
Unbiased Drug Target Prediction Reveals Sensitivity to Ferroptosis Inducers, HDAC and RTK Inhibitors in Melanoma Subtypes
Authors: Pla Indira , Szabolcs Botond L. , Péter Petra Nikolett , Ujfaludi Zsuzsanna , Kim Yonghyo , Horvatovich Peter , Sanchez Aniel , Pawlowski Krzysztof , Wieslander Elisabet , Kuras Magdalena , Murillo Jimmy Rodriguez , Guedes Jéssica , Pál Dorottya M.P. , Ascsillán Anna A. , Betancourt Lazaro Hiram , Németh István Balázs , Gil Jeovanis , de Almeida Natália Pinto , Szeitz Beáta , Szadai Leticia , Doma Viktória , Woldmar Nicole , Bartha Áron , Pahi Zoltan , Pankotai Tibor , Győrffy Balázs , Szasz A. Marcell , Domont Gilberto , Nogueira Fábio , Kwon Ho Jeong , Appelqvist Roger , Kárpáti Sarolta , Fenyö David , Malm Johan , Marko‐Varga György , Kemény Lajos V. 
Published: December 2024

AbstractBackgroundThe utilization of PD1 and CTLA4 inhibitors has revolutionized the treatment of malignant melanoma (MM). However, resistance to targeted and immune‐checkpoint‐based therapies still poses a significant problem.ObjectiveHere, we mine large‐scale MM proteogenomic data to identify druggable targets and forecast treatment efficacy and resistance.MethodsLeveraging protein profiles from established MM subtypes and molecular structures of 82 cancer treatment drugs, we identified nine candidate hub proteins, mTOR, FYN, PIK3CB, EGFR, MAPK3, MAP4K1, MAP2K1, SRC, and AKT1, across five distinct MM subtypes. These proteins are potential drug targets applicable to one or multiple MM subtypes. Additionally, by integrating proteogenomic profiles obtained from MM subtypes with MM cell line dependency and drug sensitivity data, we identified a total of 162 potentially targetable genes. Lastly, we identified 20 compounds exhibiting potential drug impact in at least one melanoma subtype.ResultsEmploying these unbiased approaches, we have uncovered compounds targeting ferroptosis demonstrating a striking 30× fold difference in sensitivity among different subtypes.ConclusionsOur results suggest innovative and novel therapeutic strategies by stratifying melanoma samples through proteomic profiling, offering a spectrum of novel therapeutic interventions and prospects for combination therapy.
Sintering‐resistant porous BaZrO3 ceramics using a particle‐stabilized foam method for thermal insulation applications
Authors: Liu Bin , Fan Jie , Nian Hongqiang , Li Yiran , Xiang Huimin , Zhou Yanchun 
Published: December 2024

AbstractSintering and phase transitions of materials in current large‐area thermal insulation systems are critical problems for hypersonic vehicles. Searching for thermal insulation materials with good structure stability, thermal stability, and superior insulation performance is urgent for the development of these vehicles. Herein, we reported a novel porous BaZrO3 ceramic fabricated by a particle‐stabilized foam method. By controlling the sintering temperature, the porosity (92.96%–94.62%), thermal conductivity (0.088–0.193 W/(m·K)), and strength (0.30–1.31 MPa) of the porous ceramics are tunable. Most importantly, these porous BaZrO3 ceramics exhibit excellent sintering resistance. After being heat treated at 1300°C for 6 h, the shrinkage of porous BaZrO3 ceramics is nearly 0. The shrinkage of the samples heat‐treated even at 1600°C is still lower than 3%, demonstrating outstanding high‐temperature structure stability. Our results demonstrate that porous BaZrO3 ceramics are promising candidates for high‐temperature thermal insulation applications.
Comprehensive Analysis of Bulk RNA‐Seq and Single‐Cell RNA‐Seq Data Unveils Sevoflurane‐Induced Neurotoxicity Through SLC7A11‐Associated Ferroptosis
Authors: Hu Xiaolan , Zhang Yiping , Guo Lian , Xiao Renjie , Yuan Linhui , Liu Fen 
Published: December 2024

ABSTRACTSevoflurane's potential impact on cognitive function and neurodevelopment, especially in susceptible populations such as infants and the elderly, has raised widespread concern. This study focuses on how sevoflurane induces ferroptosis in astrocytes and identifies solute carrier family 7 member 11 (SLC7A11) as a mediator of ferroptosis, providing new insights into sevoflurane‐related neurotoxic pathways. We analysed single‐cell sequencing (scRNA‐seq) data from sevoflurane‐exposed mice and control mice, supplemented with bulk RNA‐seq data, to assess gene expression alterations. Additionally, pregnant mice were subjected to in vivo experiments, and in vitro studies using U251 astrocytoma cells were conducted to evaluate sevoflurane's neurotoxic effects on offspring, focusing on ferroptosis markers and SLC7A11 expression. Sevoflurane exposure led to learning, memory and behavioural deficits in offspring, associated with decreased SLC7A11 expression and increased signs of ferroptosis. In U251 cells, sevoflurane reduced cell viability, increased reactive oxygen species (ROS) levels and affected the expression of ferroptosis regulatory factors, supporting the hypothesis that sevoflurane induces astrocyte ferroptosis through SLC7A11 modulation. Molecular docking experiments suggest a direct interaction between sevoflurane and SLC7A11. This study provides mechanistic insights into sevoflurane‐induced neurotoxicity, emphasising the importance of SLC7A11 in regulating astrocyte ferroptosis. Our findings highlight the potential for targeting ferroptosis pathways to mitigate the adverse effects of sevoflurane anaesthesia.
Oxidative balance is associated with diabetic kidney disease and mortality in adults with diabetes mellitus: Insights from NHANES database and Mendelian randomization
Authors: Jiang Li , Jian Jie , Sai Xulin , Yu Hongda , Liang Wanxian , Wu Xiai 
Published: December 2024

ABSTRACTObjectiveTo explore and validate the association between the oxidative balance and prevalence of diabetic kidney disease (DKD) and mortality in patients with diabetes.Study designA large and representative sample from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2016 was analyzed to study the potential association between Oxidative Balance Score (OBS) and prognosis of DKD in adult diabetic patients. Weighted multivariate logistic regression analysis was conducted to examine the relationship between OBS and DKD risk. Subgroup analysis, sensitivity analysis, and mediation effect analysis were conducted to explore the effect of the covariates and assess the robustness of the findings. Mendelian randomization (MR) was employed to evaluate the correlated relationship between mitochondrial reactive oxygen species (ROS) levels and DKD at the genetic level.ResultThe highest OBS quartile showed the most significant negative correlation with DKD compared to the lowest OBS quartile (OR = 0.62, 95% CI 0.41–0.92, P = 0.017). Higher OBS was associated with a reduced risk of DKD (OR = 0.96; 95% CI = 0.93, 0.98; P < 0.001) and mortality (P = 0.021 by log‐rank) in diabetic patients. This association remained robust even after excluding individual OBS components. Subgroup analysis revealed the interaction of metabolic syndrome on OBS was significant. Mediation analyses revealed that OBS's effect on DKD was independent of blood uric acid and cholesterol. Restricted cubic spline (RCS) analysis indicated a typical L‐shaped relationship between OBS and DKD risk. The physical activity was identified as the core variable predicting DKD risk by two machine learning algorithms. MR showed a potential correlated relationship between ROS and microalbuminuria in DKD.ConclusionsThe high level of oxidative balance score was negatively correlated with the risk of DKD and mortality in diabetic patients.
Gastrointestinal symptoms in patients receiving imeglimin in combination with metformin: A post‐hoc analysis of imeglimin clinical trial data
Authors: Ito Jumpei , Hagi Katsuhiko , Kochi Kenji , Ueki Kohjiro , Watada Hirotaka , Kaku Kohei 
Published: December 2024

ABSTRACTIntroductionAn increased rate of gastrointestinal (GI) symptoms is reported in patients with type 2 diabetes receiving imeglimin plus metformin vs monotherapy or in combination with other antidiabetic drugs. This post‐hoc analysis explored GI symptom incidence, risk factors for their occurrence, and the impact on therapeutic efficacy during imeglimin and metformin combination therapy.Materials and MethodsData were derived from the 52‐week, open‐label, phase 3 TIMES‐2 trial in Japanese type 2 diabetes patients. Patients in the imeglimin plus metformin group were divided into two subgroups based on the presence of GI symptoms and diarrhea, with efficacy and safety assessed. Factors associated with their occurrence were explored using multivariate logistic regression analysis.ResultsOf 64 patients analyzed, GI symptoms and diarrhea occurred in 40.6% (n = 26) and 17.2% (n = 11) of patients, respectively. Metformin dose and patient age did not significantly affect their incidence. Events occurred more frequently within the first 4 months of treatment. Approximately half resolved within 1 week, and most were mild. Type 2 diabetes duration <5 years was significantly associated with diarrhea (odds ratio = 5.979; P = 0.039). Significant hypoglycemic effects were observed from baseline, irrespective of GI symptoms or diarrhea. However, the degree of HbA1c improvement tended to be greater in patients with GI symptoms and diarrhea.ConclusionsIncreased awareness regarding the potential for GI symptoms, including diarrhea, during imeglimin plus metformin combination therapy is warranted. This data will provide clinicians with useful information regarding symptomatic treatment when it occurs and help determine whether to continue treatment administration and is expected to improve patient adherence.
Percutaneous Transhepatic Cholangioscopy in Hepatolithiasis Associated With Decompensated Cirrhosis: A Retrospective Cohort Study
Authors: Yan Qianyu , Zhang Jie , Chen Rui , Zhang Jingyi , Zhou Rongxing 
Published: December 2024

ABSTRACTBackgroundMultiple and complicated hepatolithiasis can be associated with decompensated cirrhosis. Endoscopic retrograde cholangiopancreatography is unavailable for multiple and complicated hepatolithiasis, and the mainstay for decompensated cirrhosis is liver transplantation. However, due to the ethical factors and the complexity of operation, liver transplantation cannot be widely operated. This study aimed to evaluate percutaneous transhepatic cholangioscopy in the extraction of stones and the recompensation of cirrhosis in patients with hepatolithiasis associated with decompensated cirrhosis.MethodsBetween January 2021 and February 2024, we retrospectively reviewed the clinical data of 21 patients with multiple and complicated hepatolithiasis associated with decompensated cirrhosis. Before PTCS, the 21 patients were all assessed by the Model for End‐stage Liver Disease as having indications for liver transplantation. One‐step PTCS (n = 19) and two‐step PTCS (n = 2) were used to remove the stones.ResultsThe technical success rate was 100%, and most stones were cleared 90.48% (19/21). After 3 months of PTCS, MELD score of the patients had significantly decreased (10.81 ± 3.31 vs. 17.24 ± 3.40, p < 0.05), and it was lowest at 6 months after the operation (9.94 ± 4.31). After a median follow‐up period of 18 months (up to 40 months), the stone recurrence rate was 28.57% (6/21), 13 patients survived without liver transplantation, three patients underwent liver transplantation and survived, and five patients died of liver failure or cancer (mortality rate 23.81%).ConclusionsPTCS can significantly improve patients’ liver function in hepatolithiasis associated with decompensated cirrhosis.
The Perception of Unilateral Recessions in the Maxillary Esthetic Zone: A Survey Among Dentists and Non‐Professionals
Authors: Fürhauser Nikolaus , Rosen Rebecca , Fürhauser Lukas , Fürhauser Rudolf 
Published: December 2024

ABSTRACTStatement of ProblemEsthetic dental features, especially the maxillary anterior teeth, significantly influence perceived attractiveness. Gingival recessions can negatively affect smile esthetics, particularly when asymmetrical.PurposeThis study aimed to investigate the perception of dentists and non‐professionals regarding subtle variations in the apically displaced soft tissue surrounding a lateral or central incisor.Materials and MethodsBased on an ideal image of the esthetic zone, asymmetrical modifications of either a central or lateral incisor in the maxillary anterior were created and used in a digital survey asking participants to assess the overall appearance of the smile, using a visual analog scale (VAS). The dental expertise, age, and gender of the participants were recorded. For each image, the question was posed to identify if any of the teeth caused a visible irritation. The mean results of each tooth alteration and the correlation between dental expertise were statistically analyzed.ResultsA total of 114 participants were polled. There was a significant difference in the esthetic perception between the central and lateral incisors (p < 0.001). The perception threshold for a noticeable asymmetrical recession was 1.2 mm for the central and 2.0 mm for the lateral incisor. Gender and age showed no significant difference in the esthetic evaluation, and dental expertise was only significantly different for larger recessions (p < 0.05).ConclusionThe asymmetric changes were more noticeable for the central incisor than the lateral incisor. A unilateral recession change of 0.8 mm did not appear to influence the assessment of the overall smile. The dental expertise, age, or gender of the participants did not significantly correlate with a stricter esthetic perception.Clinical ImplicationsThe present study highlights that the perception of unilateral recession changes in the anterior maxilla varies between central and lateral incisors, with lateral incisor recessions being less impactful on the overall appearance of the smile. These findings suggest that small gingival changes can be acceptable for the overall esthetic outcome, underscoring the importance of discussing patient expectations and treatment options before restoration or orthodontic treatment and prioritizing the gingival margin of the central incisor which appeared more noticeable.
Entrepreneurial Resourcefulness: Theoretical Origins, Integrative Review, and Research Agenda
Authors: Williams Trenton Alma , Li Joanna Mingxuan , Zhao Eric Yanfei 
Published: December 2024

AbstractEntrepreneurial resourcefulness is frequently invoked as an essential quality needed to succeed in the entrepreneurship processes. As such, recent years have seen a proliferation of a diverse body of scholarship on entrepreneurial resourcefulness. While this diversity demonstrates the promise and depth of entrepreneurial resourcefulness, this research is fragmented across disciplines, theories, and levels of analysis, which limits our understanding of when, why, and how entrepreneurial resourcefulness occurs and its effect on the entrepreneurial process. This study reviews and integrates the literature on entrepreneurial resourcefulness, providing a common foundational grounding that coheres diverse yet related streams of research. As an outcome of the review, we offer a definition of entrepreneurial resourcefulness that is anchored in its diverse theoretical origins and synthesize relevant research. In building on the foundation offered by the review, we identify the most critical areas for future research with the potential to build upon and extend the theoretical insights derived from the review.
Disparities in telehealth utilization between US rural and urban areas during the COVID‐19 pandemic
Authors: Bin Abdul Baten Redwan , Zohora Fatema Tuz , Siddiqui Muhammad Umar Hasan 
Published: December 2024

AbstractPurposeDuring the COVID‐19 pandemic, telehealth services were expanded across the United States to meet the increased demand and safety requirements of care. This observational study aims to understand rural‐urban differences in telehealth utilization during the early part of the COVID‐19 pandemic.MethodsIndividual‐level data from the National Health Interview Survey 2020‐2021 (age ≥18) were analyzed for this study. The Propensity Score Matching method with multivariable Ordinary Least Square was used to analyze 2 outcome variables—(1) having a medical appointment by video or phone in the past 12 months and (2) having a virtual one for reasons related to the pandemic. Event study models were analyzed to understand the trend of telehealth utilization throughout 6 quarters of the pandemic. Subgroup analysis by health insurance, age, sex, race, citizenship, and disability status was performed to identify underlying disparities between rural and urban residents.FindingsAnalysis reveals that rural respondents (N = 6,984) were 8.7 percentage points (P<.001) less likely than urban respondents (N = 40,207) to have a medical appointment by video or phone. Rural residents were 8.1 percentage points (P<.001) less likely to have had a virtual medical appointment because of reasons related to the COVID‐19 pandemic than urban users. The event study showed that rural‐urban telehealth utilization disparities persisted throughout the pandemic. Subgroup analysis revealed significant rural‐urban disparities in telehealth utilization by demographic characteristics.ConclusionsResults demonstrate that rural residents were less likely than urban residents to utilize telehealth services during the COVID‐19 pandemic, highlighting concerns about access to care for rural residents.
Assessing the Use and Acceptability of Virtual Reality to Assist Coping in Children Undergoing Clinical Procedures
Authors: Samnakay Sarah , Bell Emily , Evans Daisy , Sommerfield David , Sommerfield Aine , Hauser Neil , von Ungern‐Sternberg Britta S. 
Published: December 2024

ABSTRACTPurposeVirtual reality is used as a distraction tool during medical procedures that can cause anxiety and pain. We assessed the usefulness, engagement, value and feasibility of virtual reality to help children cope with routine clinical procedures.Design and MethodsQuality improvement study. Children, 4–16 years old, were given the option to use virtual reality during their procedure in oncology, immunology or diabetes clinics, or during an induction of general anesthesia. The emotional state of the child was documented using the children's emotional manifestation scale. We assessed feedback from patients, parents, and clinicians.ResultsAcross all clinics, children responded positively to the virtual reality and 80% would choose to use virtual reality again for health‐related procedures. Parents and clinicians, respectively, reported that virtual reality helped children tolerate the procedure (82% and 87%), engaged children well (82% and 89%) and was a valuable tool (85% and 98%). Clinicians (90%) endorsed the feasibility of using virtual reality during procedures.Practice ImplicationsThis project demonstrated that virtual reality can be implemented as a useful, engaging and feasible tool to help children tolerate a variety of routine medical procedures. However, ensuring comfortable fit of virtual reality devices and diversifying the visual content is necessary.