bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measurement Indicators of Age-Friendly Communities: Findings From the AARP Age-Friendly Community Survey
Authors: Kim Kyeongmo , Buckley Tommy , Burnette Denise , Kim Seon , Cho Sunghwan 
Published: April 2021

Abstract

Background and Objectives
Cities and counties worldwide have adopted the concept of “age-friendly communities.” These communities aspire to promote older adults’ well-being by providing a safe, affordable built environment and a social environment that encourages their participation. A major limitation in this field is the lack of valid and reliable measures that capture the complex dimensionality and dynamic nature of the aging–environment interface.

Research Design and Methods
This study uses data from the AARP 2016 Age-Friendly Community Surveys (N = 3,652 adults aged 65 and older). The survey includes 62 indicators of age-friendliness, for example, outdoor spaces, transportation, housing, social participation, and community and health services. We randomly split the sample into 2 equal subsamples for confirmatory factor analysis (CFA) and structural equation modeling (SEM).

Results
CFA results indicated that both the 5-factor model and the second-order factor model adequately fit the data. In the SEM 5-factor model, outdoor space (β = 0.134; p = .017), social participation (β = 0.307; p &lt; .001), and community and health services (β = −0.149; p = .008) were associated with self-rated health, the outcome of interest. The path coefficients of housing and transportation were not significant. In the second-order factor model, people who lived in more age-friendly communities reported better self-rated health (β = 0.295; p &lt; .001).

Discussion and Implications
Our findings show that the Age-Friendly Community Survey measures demonstrate reliability and concurrent validity. To promote older adults’ well-being, practitioners, policymakers, and researchers should focus on improving their built and social environments. They can use these measures for short- and long-term planning, monitoring, and evaluating age-friendly community initiatives.
Mapping the Evidence on Rapid Diagnosis of Bloodstream Infections: A Scoping Review
Authors: Rubinstein Matthew L , Wolk Donna M , Babady N. Esther , Johnson J. Kristie , Atkinson Bridgette , Makim Roshni , Parrott J. Scott 
Published: April 2021

AbstractBackgroundLaboratory and other healthcare professionals participate in developing clinical practice guidelines through systematic review of the evidence. A significant challenge is the identification of areas for analytic focus when the evidence consists of several categories of interventions and outcomes that span both laboratory and clinical processes. The challenge increases when these interventions present as sets of combined interventions. A scoping review may provide a transparent and defensible analytic route forward for systematic reviews challenged in this manner.ContentA scoping review was carried out to characterize the evidence on rapid identification of bloodstream infections. Fifty-five studies previously identified by the supported systematic review were charted in duplicate. Charted records were analyzed using descriptive content analysis and evidence mapping with a 5-step process.SummaryThe 5-step analysis culminated in the characterization of 9 different intervention chain configurations that will facilitate the comparison of complex intervention practices across studies. Furthermore, our evidence map indicates that the current evidence base is strongly centered on 3 specific clinical outcomes, and it links these outcomes to the most represented intervention chain configurations. The scoping review effort generated a route forward for the supported systematic review and meta-analysis.
Evaluation of a Capillary Electrophoresis System for the Separation of Proteins
Authors: Favresse Julien , Yolande Lenga , Gras Jeremie 
Published: April 2021

Abstract

Background
Serum protein electrophoresis is one of the core investigations for screening for monoclonal proteins. Among the available capillary systems, the Helena V8 system has been evaluated in a limited number of studies.

Methods
In total, 310 sera samples were assessed on the Helena V8 system and compared with the Sebia Capillarys instrument. Abnormalities suggestive of monoclonal proteins were confirmed by immunofixation. Imprecision studies and reference intervals were determined.

Results
The imprecision of the Helena V8 was inferior or equal to 5.8%. The mean bias of Helena V8 vs Sebia Capillarys was about −0.9 g/L for albumin; −0.2 g/L for alpha-1; 1.1 g/L for alpha-2; −0.2 g/L for beta; 0.3 g/L for gamma; −0.5 g/L for monoclonal protein in beta; and 0.3 g/L for monoclonal protein in gamma. Among the 56 samples with monoclonal proteins confirmed by immunofixation, all were seen on both methods, with only 1 discordant result at a cutoff of 5.0 g/L. Reference intervals were statistically different between the 2 analyzers, except for the beta fraction.

Conclusions
Our evaluation confirms the good analytical performance of the Helena V8 analyzer as a suitable alternative to the Sebia Capillarys instrument.
Legal Diversity at the International Criminal Court
Authors: Schmitt Bertram 
Published: April 2021

Abstract
The procedural law of the International Criminal Court (ICC) combines common law and civil law concepts in a ‘unique compromise’. It gives the judges broad discretion to determine which adversarial and inquisitorial elements fit best into the overall system of the Rome Statute. In exercising their discretion judges cannot, of course, deny their legal background. However, sticking to the familiar practice is an impediment to the effective procedural functioning of the Court. To find meaningful solutions within the legal framework of the ICC requires instead an attitude based on the assumption that no legal system is superior to the other and the ability to doubt legal concepts that one might consider as self-evident. To this end, it is necessary that judges develop an understanding of the procedural system that they have not experienced in their former professional life. The article discusses nine examples of the procedural law and practice of the ICC — from the role of the prosecutor to victims participation — and examines the reasons for, and implications of, the transfer of adversarial and inquisitorial elements into the ICC`s statutory framework.
The contribution of PIP2-type aquaporins to photosynthetic response to increased vapour pressure deficit
Authors: Israel David , Khan Shanjida , Warren Charles R , Zwiazek Janusz J , Robson T Matthew 
Published: April 2021

Abstract
The roles of different plasma membrane aquaporins (PIPs) in leaf-level gas exchange of Arabidopsis thaliana were examined using knockout mutants. Since multiple Arabidopsis PIPs are implicated in CO2 transport across cell membranes, we focused on identifying the effects of the knockout mutations on photosynthesis, and whether they are mediated through the control of stomatal conductance of water vapour (gs), mesophyll conductance of CO2 (gm), or both. We grew Arabidopsis plants in low and high humidity environments and found that the contribution of PIPs to gs was larger under low air humidity when the evaporative demand was high, whereas any effect of a lack of PIP function was minimal under higher humidity. The pip2;4 knockout mutant had 44% higher gs than wild-type plants under low humidity, which in turn resulted in an increased net photosynthetic rate (Anet). We also observed a 23% increase in whole-plant transpiration (E) for this knockout mutant. The lack of functional plasma membrane aquaporin AtPIP2;5 did not affect gs or E, but resulted in homeostasis of gm despite changes in humidity, indicating a possible role in regulating CO2 membrane permeability. CO2 transport measurements in yeast expressing AtPIP2;5 confirmed that this aquaporin is indeed permeable to CO2.
Hmg1 mutations in Aspergillus fumigatus and their contribution to triazole susceptibility
Authors: Arai Teppei , Umeyama Takashi , Majima Hidetaka , Inukai Tatsuya , Watanabe Akira , Miyazaki Yoshitsugu , Kamei Katsuhiko 
Published: April 2021

Abstract

Triazole-resistant Aspergillus fumigatus is a global health concern. In general, each triazole resistance pattern caused by the specified amino acid substitution of Cyp51A has a typical pattern depending on the mutation site. We evaluated the contribution of both Cyp51A and Hmg1 mutations to atypical triazole resistance in A. fumigatus. We used clinical triazole-resistant A. fumigatus strains collected in Japan and investigated the sequences of cyp51A and hmg1 genes. To delineate the association between the hmg1 mutation and atypical triazole resistance, the mutant hmg1 alleles in clinical multi-azole resistant strains were replaced with the wild-type hmg1 allele by CRISPR/Cas9 system. In our study, the combination of Cyp51A mutation and Hmg1 mutation was shown to additively contribute to triazole resistance. We also demonstrated that the triazole resistance conferred by the Hmg1 mutation showed a different pattern depending on the mutation site, similar to the Cyp51A mutation. Our results indicate that focusing on the phenotypes of multiple genes is essential to clarify the overall picture of the triazole resistance mechanism of A. fumigatus.

Lay Summary
The number of triazole-resistant Aspergillus fumigatus is increasing. We confirmed thatmutation in a hydroxymethylglutaryl-CoA reductase (Hmg1) in the fungus contributesto the resistance separately from Cyp51A mutation, and that susceptibility patterns aredifferent based on mutation site.
Jet properties of XTE J1752−223 during its 2009–2010 outburst
Authors: Debnath Dipak , Chatterjee Kaushik , Chatterjee Debjit , Jana Arghajit , Chakrabarti Sandip K 
Published: April 2021

ABSTRACT
Galactic short orbital period black hole candidate (BHC) XTE J1752−223 was discovered on 2009 October 21 by the Rossi X-ray Timing Explorer (RXTE). We study the spectral properties of this outburst using transonic flow solution based two component advective flow (TCAF) model. TCAF model fitted spectrum gives an estimation of the physical flow parameters, such as the Keplerian disc rate, sub-Keplerian halo rate, properties of the so-called Compton cloud, other than the mass of the source and normalization (N). N is a standardized ratio of emitted to observed photon flux in TCAF that does not include X-ray emission from jets. In the presence of jets, this ratio changes and this deviation is used to obtain the estimation of X-ray contribution from the jets. Nature of the jet is found to be compact during low luminous hard state and discrete or blobby during high luminous intermediate states. We find a correlation between the radio (5.5 GHz) and X-ray (2.5–25 keV) fluxes from different components. The radio (FR) and jet X-ray (Fouf) fluxes are found to be correlated within the acceptable range of the standard correlation (0.6 to 0.7). A similar correlation indices were reported by our group for three other short orbital period transient BHCs (Swift J1753.5−0127, MAXI J1836−194, and XTE J1118+480).
On the use of the local prior on the absolute magnitude of Type Ia supernovae in cosmological inference
Authors: Camarena David , Marra Valerio 
Published: April 2021

ABSTRACT
A dark-energy, which behaves as the cosmological constant until a sudden phantom transition at very low redshift (z &lt; 0.1), seems to solve the &gt;4σ disagreement between the local and high-redshift determinations of the Hubble constant, while maintaining the phenomenological success of the Λ cold dark matter model with respect to the other observables. Here, we show that such a hockey-stick dark energy cannot solve the H0 crisis. The basic reason is that the supernova absolute magnitude MB that is used to derive the local H0 constraint is not compatible with the MB that is necessary to fit supernova, baryon acoustic oscillation, and cosmic microwave background data, and this disagreement is not solved by a sudden phantom transition at very low redshift. We make use of this example to show why it is preferable to adopt in the statistical analyses the prior on MB as an alternative to the prior on H0. The three reasons are: (i) one avoids potential double counting of low-redshift supernovae, (ii) one avoids assuming the validity of cosmography, in particular, fixing the deceleration parameter to the standard model value q0 = −0.55, (iii) one includes in the analysis the fact that MB is constrained by local calibration, an information which would otherwise be neglected in the analysis, biasing both model selection and parameter constraints. We provide the priors on MB relative to the recent Pantheon and DES-SN3YR supernova catalogs. We also provide a Gaussian joint prior on H0 and q0 that generalizes the prior on H0 by Supernova H0 for the Equation of State.
Homogeneous analysis of globular clusters from the APOGEE survey with the BACCHUS code – III. ω Cen
Authors: Mészáros Szabolcs , Masseron Thomas , Fernández-Trincado José G , García-Hernández D A , Szigeti László , Cunha Katia , Shetrone Matthew , Smith Verne V , Beaton Rachael L , Beers Timothy C , Brownstein Joel R , Geisler Doug , Hayes Christian R , Jönsson Henrik , Lane Richard R , Majewski Steven R , Minniti Dante , Munoz Ricardo R , Nitschelm Christian , Roman-Lopes Alexandre , Zamora Olga 
Published: April 2021

ABSTRACT
We study the multiple populations of ω Cen by using the abundances of Fe, C, N, O, Mg, Al, Si, K, Ca, and Ce from the high-resolution, high signal-to-noise (S/N &gt; 70) spectra of 982 red giant stars observed by the SDSS-IV/APOGEE-2 survey. We find that the shape of the Al–Mg and N–C anticorrelations changes as a function of metallicity, continuous for the metal-poor groups, but bimodal (or unimodal) at high metallicities. There are four Fe populations, similarly to previous literature findings, but we find seven populations based on Fe, Al, and Mg abundances. The evolution of Al in ω Cen is compared to its evolution in the Milky Way and in five representative globular clusters. We find that the distribution of Al in metal-rich stars of ω Cen closely follows what is observed in the Galaxy. Other α-elements and C, N, O, and Ce are also compared to the Milky Way, and significantly elevated abundances are observed over what is found in the thick disc for almost all elements. However, we also find some stars with high metallicity and low [Al/Fe], suggesting that ω Cen could be the remnant core of a dwarf galaxy, but the existence of these peculiar stars needs an independent confirmation. We also confirm the increase in the sum of CNO as a function of metallicity previously reported in the literature and find that the [C/N] ratio appears to show opposite correlations between Al-poor and Al-rich stars as a function of metallicity.
Free Will for the Long Run
Authors: Huff Benjamin I 
Published: April 2021

Abstract
For beings that have a beginning in time, free will seems impossible, because our choices seem to be a result of past events over which we had no control. Latter-day Saint theology offers what seems a simple solution: the idea that human beings have always existed in the form of spirits or “intelligences.” While this idea solves some key puzzles, contemplating an infinite past also brings the recognition that causal autonomy is not enough for freedom. A crucial feature of humanity is the ability to move beyond past choices and versions of ourselves. Human freedom involves a dynamic process of identification, alienation, and re-identification through which we develop, improve, and mature as agents. Thinking about freedom over the long run, with attention to both the past and the future, casts the traditional debate over free will in a distinctive light, suggesting fresh possibilities.
m6A RNA methylation of major satellite repeat transcripts facilitates chromatin association and RNA:DNA hybrid formation in mouse heterochromatin
Authors: Duda Katarzyna J , Ching Reagan W , Jerabek Lisa , Shukeir Nicholas , Erikson Galina , Engist Bettina , Onishi-Seebacher Megumi , Perrera Valentina , Richter Florian , Mittler Gerhard , Fritz Katharina , Helm Mark , Knuckles Philip , Bühler Marc , Jenuwein Thomas 
Published: April 2021

Abstract
Heterochromatin has essential functions in maintaining chromosome structure, in protecting genome integrity and in stabilizing gene expression programs. Heterochromatin is often nucleated by underlying DNA repeat sequences, such as major satellite repeats (MSR) and long interspersed nuclear elements (LINE). In order to establish heterochromatin, MSR and LINE elements need to be transcriptionally competent and generate non-coding repeat RNA that remain chromatin associated. We explored whether these heterochromatic RNA, similar to DNA and histones, may be methylated, particularly for 5-methylcytosine (5mC) or methyl-6-adenosine (m6A). Our analysis in mouse ES cells identifies only background level of 5mC but significant enrichment for m6A on heterochromatic RNA. Moreover, MSR transcripts are a novel target for m6A RNA modification, and their m6A RNA enrichment is decreased in ES cells that are mutant for Mettl3 or Mettl14, which encode components of a central RNA methyltransferase complex. Importantly, MSR transcripts that are partially deficient in m6A RNA methylation display impaired chromatin association and have a reduced potential to form RNA:DNA hybrids. We propose that m6A modification of MSR RNA will enhance the functions of MSR repeat transcripts to stabilize mouse heterochromatin.
Henry Tye: the future of theoretical physics and advice to young researchers
Authors: Cai Yi-Fu , Yan Sheng-Feng 
Published: April 2021

Abstract
Professor Henry Tye (戴自海) is a world-renowned expert in theoretical particle physics, string theory and cosmology. He was recently the IAS Professor at the Jockey Club Institute for Advanced Study (IAS) and the Hong Kong University of Science and Technology (HKUST), and is the Horace White Professor of Physics (Emeritus) at Cornell University. He has a lot of experience in research status in both China and the United States. Recently, NSR invited Professor Yi-Fu Cai (蔡一夫) from the University of Science and Technology of China (USTC) to interview Prof. Tye on his personal views on the future of theoretical physics, his own experience, and his advice to young researchers.
Positive and Negative Constitutionalism and the Limits of Universalism: A Review Essay
Authors: Stone Adrienne , Weis Lael K 
Published: April 2021

Abstract—
In The Principles of Constitutionalism, Nicholas Barber provides a sophisticated yet highly readable introduction to fundamental constitutional principles. At the same time, Barber seeks to reorient constitutional theory scholarship away from a mistaken ‘negative’ understanding of constitutionalism towards a ‘positive’ understanding. This essay examines that argument. We suggest that the idea of ‘positive constitutionalism’ has a weaker and a stronger sense. In its weak form, the argument calls for greater attention to what constitutions enable as well as what they restrict, and thus serves as a welcome reminder of the full potential of constitutional principles. However, it cannot be regarded as the correction of a widespread mistake. In its strong form, the argument calls for greater recognition that the state’s essential function lies in advancing the ‘well-being’ of its members. Although this amounts to a significant reorientation, it weakens the theory’s claim to universalism. These tensions indicate limitations to efforts to construct general theories of constitutionalism.
The Effectiveness of Social Media in the Dissemination of Knowledge About Pain in Dementia
Authors: Castillo Louise I R , Hadjistavropoulos Thomas , Brachaniec Mary 
Published: April 2021

Abstract

Objectives
Traditional knowledge dissemination methods have been ineffective in leading to timely and widespread changes in clinical practice. Social media have the potential to reach broader audiences than more traditional methods that disseminate research findings. We evaluated the effectiveness of using social media to mobilize knowledge about pain in dementia.

Methods
We developed an online repository of evidence-based content (e.g., guidelines, assessment approaches) and a video about pain in dementia. The video was uploaded to YouTube, a video-sharing platform. We collaborated with stakeholder organizations on a 5-month social media campaign (#SeePainMoreClearly) on Twitter, a social networking site, to disseminate digital content about pain in dementia. The response to our initiatives was evaluated with Web and social media metrics, a video questionnaire, and a comparison of the extent of Twitter discussions about pain in dementia before and during the campaign period.

Results
Web metrics showed a great reach of the initiative: The #SeePainMoreClearly hashtag received more than 5,000,000 impressions and was used in 31 countries. The online repository was viewed by 1,218 individuals from 55 countries, and the video resulted in 51,000 views. Comparisons between the pre-campaign and campaign periods demonstrated a higher number of posts about pain in dementia during the campaign period.

Conclusion
The findings have implications for closing the knowledge-to-practice gap in dementia care through faster mobilization of scientific findings. Our campaign compares favorably with other health information dissemination initiatives. The methodologies used in the study could serve as a framework for the development of social media initiatives in other health disciplines.
Increased representation of the non-dominant hand in pianists demonstrated by measurement of 3D morphology of the central sulcus
Authors: Harvey Adam , Hou Lewis , Davidson-Kelly Kirsteen , Schaefer Rebecca S , Hong Sujin , Mangin Jean-François , Overy Katie , Roberts Neil 
Published: April 2021

Abstract

Background
Post-mortem and magnetic resonance imaging (MRI) studies of the central sulcus, as an indicator of motor cortex, have shown that in the general population there is greater representation of the dominant compared to the non-dominant hand. Studies of musicians, who are highly skilled in performing complex finger movements, have suggested this dominance is affected by musical training, but methods and findings have been mixed.

Objective
In the present study, an automated image analysis pipeline using a 3D mesh approach was applied to measure central sulcus (CS) asymmetry on MR images obtained for a cohort of right-handed pianists and matched controls.

Methods
The depth, length, and surface area (SA) of the CS and thickness of the cortical mantle adjacent to the CS were measured in each cerebral hemisphere by applying the BrainVISA Morphologist 2012 software pipeline to 3D T1-weighted MR images of the brain obtained for 15 right-handed pianists and 14 controls, matched with respect to age, sex, and handedness. Asymmetry indices (AIs) were calculated for each parameter and multivariate analysis of covariance (MANCOVA), and post hoc tests were performed to compare differences between the pianist and control groups.

Results
A one-way MANCOVA across the four AIs, controlling for age and sex, revealed a significant main effect of group (P = 0.04), and post hoc analysis revealed that while SA was significantly greater in the left than the right cerebral hemisphere in controls (P &lt; 0.001), there was no significant difference between left and right SA in the pianists (P = 0.634). Independent samples t-tests revealed that the SA of right CS was significantly larger in pianists compared to controls (P = 0.015), with no between-group differences in left CS.

Conclusions
Application of an image analysis pipeline to 3D MR images has provided robust evidence of significantly increased representation of the non-dominant hand in the brain of pianists compared to age-, sex-, and handedness-matched controls. This finding supports prior research showing structural differences in the central sulcus in musicians and is interpreted to reflect the long-term motor training and high skill level of right-handed pianists in using their left hand.