bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness and Safety of Apixaban versus Warfarin in Venous Thromboembolism Patients with Chronic Kidney Disease
Authors: Cohen Alexander T. , Sah Janvi , Dhamane Amol D. , Lee Theodore , Rosenblatt Lisa , Hlavacek Patrick , Emir Birol , Delinger Rachel , Yuce Huseyin , Luo Xuemei 
Published: December 2021

AbstractThere has been limited evidence reported about the outcomes of oral anticoagulants among patients with venous thromboembolism (VTE) and chronic kidney disease (CKD), especially those with stage V/end-stage renal disease (ESRD). This retrospective cohort analysis of five U.S. claims databases evaluated the risk of recurrent VTE, major bleeding (MB), and clinically relevant nonmajor bleeding (CRNMB) for apixaban versus warfarin among VTE patients diagnosed with CKD, including ESRD. Inverse probability treatment weighting (IPTW) was used to balance patient characteristics between treatment cohorts. Hazard ratios (HRs) were calculated for recurrent VTE, MB, and CRNMB among patients with CKD who experienced an index VTE. An interaction analysis was conducted to evaluate treatment effects across different stages of CKD. A total of 29,790 VTE patients with CKD were selected for analyses, of whom 10,669 (35.8%) initiated apixaban and 19,121 (64.2%) initiated warfarin. Among IPTW-balanced patient cohorts, the apixaban group had significantly lower risk of recurrent VTE (HR: 0.78; 95% confidence interval [CI]: 0.66–0.92), MB (HR: 0.76; 95% CI: 0.65–0.88), and CRNMB (HR: 0.86; 95% CI: 0.80–0.93) than the warfarin group. When stratified by CKD stage (stage I/II: 8.2%; stage III: 49.4%; stage IV: 12.8%; stage V/ESRD: 12.0%; stage unspecified: 17.6%), no significant interaction was observed for effects of apixaban versus warfarin on recurrent VTE or MB. In summary, apixaban was associated with a significantly lower risk of recurrent VTE and MB than warfarin among VTE patients with CKD. CKD stages did not have significant impact on treatment effects for recurrent VTE and MB.
An Experimental Study on Timing in Tracheal Stenosis Surgery
Authors: Aydogmus Umit , Ozturk Gokhan , Kis Argun , Karakaya Yeliz Arman , Aybek Hulya , Bir Ferda 
Published: December 2021

Abstract
Background TNF-α, IL-6, and TGF-β are important bio mediators of the inflammatory process. This experimental study has investigated inflammatory biomarkers' efficacy to determine the appropriate period for anastomosis surgery in tracheal stenosis cases.
Methods First, a pilot study was performed to determine the mean stenosis ratio (SR) after the surgical anastomosis. The trial was planned on 44 rats in four groups based on the pilot study's data. Tracheal inflammation and stenosis were created in each rat by using micro scissors. In rats of groups I, II, III, and IV, respectively, tracheal resection and anastomosis surgery were applied on the 2nd, 4th, 6th, 8th weeks after the damage. The animals were euthanized 8 weeks later, followed by histopathological assessment and analysis of TNF-α, IL-6, and TGF-β as biochemical markers.
Results Mean SR of the trachea were measured as 21.9 ± 6.0%, 24.1 ± 10.4%, 25.8 ± 9.1%, and 19.6 ± 9.2% for Groups I to IV, respectively. While Group III had the worst SR, Group IV had the best ratio (p = 0.03). Group II had the highest values for the biochemical markers tested. We observed a statistically significant correlation between only histopathological changes and TNF-α from among the biochemical markers tested (p = 0.02). It was found that high TNF-α levels were in a relationship with higher SR (p = 0.01).
Conclusion Tracheal anastomosis for post-traumatic stenosis is likely to be less successful during the 4th and 6th weeks after injury. High TNF-α levels are potentially predictive of lower surgical success. These results need to be confirmed by human studies.
Continuous Remote Patient Monitoring: Evaluation of the Heart Failure Cascade Soft Launch
Authors: Chi Wei Ning , Reamer Courtney , Gordon Robert , Sarswat Nitasha , Gupta Charu , White VanGompel Emily , Dayiantis Julie , Morton-Jost Melissa , Ravichandran Urmila , Larimer Karen , Victorson David , Erwin John , Halasyamani Lakshmi , Solomonides Anthony , Padman Rema , Shah Nirav S. 
Published: December 2021

Abstract
Objective We report on our experience of deploying a continuous remote patient monitoring (CRPM) study soft launch with structured cascading and escalation pathways on heart failure (HF) patients post-discharge. The lessons learned from the soft launch are used to modify and fine-tune the workflow process and study protocol.
Methods This soft launch was conducted at NorthShore University HealthSystem's Evanston Hospital from December 2020 to March 2021. Patients were provided with non-invasive wearable biosensors that continuously collect ambulatory physiological data, and a study phone that collects patient-reported outcomes. The physiological data are analyzed by machine learning algorithms, potentially identifying physiological perturbation in HF patients. Alerts from this algorithm may be cascaded with other patient status data to inform home health nurses' (HHNs') management via a structured protocol. HHNs review the monitoring platform daily. If the patient's status meets specific criteria, HHNs perform assessments and escalate patient cases to the HF team for further guidance on early intervention.
Results We enrolled five patients into the soft launch. Four participants adhered to study activities. Two out of five patients were readmitted, one due to HF, one due to infection. Observed miscommunication and protocol gaps were noted for protocol amendment. The study team adopted an organizational development method from change management theory to reconfigure the study protocol.
Conclusion We sought to automate the monitoring aspects of post-discharge care by aligning a new technology that generates streaming data from a wearable device with a complex, multi-provider workflow into a novel protocol using iterative design, implementation, and evaluation methods to monitor post-discharge HF patients. CRPM with structured escalation and telemonitoring protocol shows potential to maintain patients in their home environment and reduce HF-related readmissions. Our results suggest that further education to engage and empower frontline workers using advanced technology is essential to scale up the approach.
Endovascular Treatment of Acute Ischemic Stroke in Patients Younger than 18 Years
Authors: Dalai Sibasankar , Limaye Uday , Kolli Satyarao , Maturu Mohan V. Sumedha , Narayana Randhi Venkata , Pati Rajesh , Korada Suresh Kumar , Vankineni Kuchelababu , Sameera Anantamakula , Datla Aravind Varma 
Published: December 2021

Abstract
Purpose Rapid and effective revascularization is very important in the treatment of acute ischemic stroke (AIS). Endovascular treatment is a promising modality in the management of AIS in young patients.
Methods We evaluated the clinical and imaging records in 14 patients younger than 18 years presenting within 6 hours of AIS. They received endovascular therapy (ET) either by mechanical thrombectomy, thromboaspiration, or both (Solumbra) between July 2017 and June 2021. The National Institute of Health Stroke Scale (NIHSS) score was calculated on admission and before the discharge of all patients. The 90-day modified Rankin Scale (mRS) score on disability-free outcome was also evaluated.
Results The mean preprocedure NIHSS score was 10.78 ± 2.11 that improved to 4.5 ± 1.88 after the procedure. Thrombolysis in cerebral infarction (TICI) grade 2b and 3 blood flow could be established in 12 (85.72%) patients. One patient had TICI 2a flow and one patient had recurrent occlusion despite repeated recanalization (TICI grade 0). The disability-free outcome, mRS score at 90 days was 0 to 1 in 12 (85.72%) patients, mRS score 2 in one (7.14%) patient, and mRS score 3 in one patient (7.14%). We did not have any major complication related to the procedure.
Conclusion ET provides high rates of arterial recanalization and favorable disability-free outcomes in young patients with AIS.
Do Orbital Implants Differ in Complication Rates: A Retrospective Study of 88 Patients, and an Argument for Cost-Effective Practices in the Face of Rising Health Care Costs
Authors: Ramji Husayn F. , Blessing Nathan W. , Tan Jeremy F. , Moreau Annie 
Published: December 2021

AbstractOperative repair of orbital fractures utilizes implants constructed of a plethora of materials that vary in cost. Surgeon preference as well as fracture complexity may dictate the implant chosen. In this study, we retrospectively compared the complication rates of the four most common types of implants utilized at our institution. We found no significant difference in complication rates in our sample of 88 patients. Additionally, the least expensive implant was as effective as the most expensive implant in addressing isolated orbital blowout fractures. This situation is not unique to the field of oculoplastics. As evidenced from published literature in other areas of surgery, from orthopaedics to orthodontics, cheaper alternatives often afford similar outcomes as more expensive options. We herein argue that a cost-effective approach should be considered while still allowing for high quality of care, in the face of rising health care costs and health disparities in America.
Social Perception of Self-Enhanced Photographs
Authors: Parsa Keon M. , Charipova Karina , Chu Eugenia , Reilly Michael J. 
Published: December 2021

AbstractThe use of appearance manipulating applications on our smartphones has increased in popularity. As the aim of this study is to determine the impact of self-directed appearance manipulation on perceptions of personality and examine the influence of respondent age and gender on the various personality domains. This cross-sectional cohort study included 20 subjects between the ages of 18 to 34 who had headshots taken and were provided an introduction on the use of the Facetune2 app. After 1 week of engaging in digital appearance manipulation, subjects submitted their self-determined most attractive edited photograph. Four surveys were constructed with 10 sets of photographs each. Each of these surveys were then sent to lay people via a web-based survey tool. Anonymous blinded respondents used a 7-point Likert scale to rate their perception of each patient's aggressiveness, likeability, sociability, trustworthiness, attractiveness, authenticity, and masculinity or femininity. A multivariate linear mixed effect model was applied to analyze the overall patient trait data as well as to assess the impact of rater age and gender. A total of 288 respondents (mean age range, 25–34 years [43%]; 202 [70%] female) completed a survey. Overall, digitally enhanced photographs were perceived as more attractive (0.22; 95% CI, 0.06–0.38). Analysis based on gender of the study subjects revealed increased attractiveness scores for men (0.19; 95% CI, 0.07–0.33). Females were also perceived as being more attractive (0.16; 95% CI, 0.03–0.40), but less authentic (−0.24; 95% CI, −0.36 to −0.12). Females rated enhanced photographs of men as less masculine (−0.23; 95% CI, −0.46 to −0.04). Raters aged 35 to 64 rated altered photos as less attractive (0.31; 95% CI, 0.09–0.52), authentic (0.20; 95% CI, 0.01–0.38), and gender enhancing (0.42; 95% CI, 0.24–0.61) compared with individuals aged 18 to 34. Patients and surgeons should be aware of the ways in which self-enhanced photographs may affect social perception.
Impact of Race, Ethnicity, and Socioeconomic Status on Nasopharyngeal Carcinoma Disease-Specific and Conditional Survival
Authors: London Ashley O. , Gallagher Liam W. , Sharma Rahul K. , Spielman Daniel , Golub Justin S. , Overdevest Jonathan B. , Yan Carol H. , DeConde Adam , Gudis David A. 
Published: December 2021

Abstract
Introduction Race, ethnicity, and socioeconomic status (SES) are complex, interconnected social determinants of health outcomes. This study uses multivariable analysis on a combination of large national datasets to examine the effects of these factors on 5-year disease-specific survival (DSS) and conditional DSS (CDSS) for nasopharyngeal carcinoma (NPC).
Methods A retrospective study of adults with NPC between 2000 and 2017 from the Surveillance, Epidemiology, End Results (SEER) registry was performed, using the National Cancer Institute Yost Index, a census tract–level composite score of SES to categorize patients. Kaplan–Meier analysis and Cox's regression for DSS and CDSS were stratified by SES. Logistic regression was conducted to identify risk factors for advanced cancer stage at time of diagnosis and receiving multimodal therapy.
Results Our analysis included 5,632 patients. DSS was significantly associated with race and SES (p < 0.01). Asian/Pacific Islander patients exhibited increased survival when controlling for other variables (hazard ratio [HR] = 0.73, p < 0.01). Although Black patients were more likely to be diagnosed with advanced disease (Black odds ratio [OR] = 1.47, p < 0.01), Black patients were also less likely to receive multimodal therapy; however, this relationship lost statistical significance once SES was incorporated into the multivariable analysis. DSS was decreased among the lowest (first) and middle (second) tertiles of SES (first HR = 1.34, p < 0.01; second HR = 1.20, p < 0.01) compared with the highest (third).
Conclusion Our results indicate that race, ethnicity, and SES significantly affect survival, stage at diagnosis, and treatment of NPC. An interplay of tumor biology and inequalities in access to care likely drives these disparities.
Infinite bound states and 1/n energy spectrum induced by a Coulomb-like potential of type III in a flat band system
Authors: Zhang Yi-Cai 
Published: December 2021

Abstract
In this work, we investigate the bound states in a one-dimensional spin-1 flat band system with a Coulomb-like potential of type III, which has a unique non-vanishing matrix element in basis ∣1〉. It is found that, for such a kind of potential, there exists infinite bound states. Near the threshold of continuous spectrum, the bound state energy is consistent with the ordinary hydrogen-like atom energy level with Rydberg correction. In addition, the flat band has significant effects on the bound states. For example, there are infinite bound states which are generated from the flat band. Furthermore, when the potential is weak, the bound state energy is proportional to the potential strength α. When the bound state energies are very near the flat band, they are inversely proportional to the natural number n (e.g., E

n
∝ 1/n, n = 1, 2, 3, …). Further we find that the energy spectrum can be well described by quasi-classical approximation (WKB method). Finally, we give a critical potential strength α

c
at which the bound state energy reaches the threshold of continuous spectrum. After crossing the threshold, the bound states in the continuum (BIC) would exist in such a flat band system.
Comparison of Modeling SPARC spiral galaxies’ rotation curves: halo models vs. MOND
Authors: Wang Lin , Chen Da-Ming 
Published: December 2021

Abstract
The tension between luminous matter and dynamical matter has long been an interesting and controversial topic in the investigation of galaxies. This is particularly true when we study spiral galaxies for which we have high quality observations of rotation curves. The solutions to the tension are proposed in two different approaches, one is the dark matter hypothesis and the other is MOdified Newtonian Dynamics (MOND) theory. When we test the solutions by using observational data of rotation curves, the controversy arises when we apply them to both low surface brightness (LSB) galaxies and high surface brightness (HSB) galaxies. Usually one likes to use the rotation curves of LSB galaxies, since dark matter is needed or the Newtonian acceleration falls below the characteristic acceleration a
0 in most regions of such galaxies, even near their centers. But for HSB galaxies, dark matter is needed or Newtonian acceleration falls below the characteristic acceleration a
0 only in their outer regions so it is helpful to single out HSB galaxies from some large sample to test the solutions. To this end, we employ a sub-sample of the rotation curves consisting of 45 non-bulgy HSB galaxies selected from the Spitzer Photometry and Accurate Rotation Curves (SPARC) database to test two dark halo models (NFW and Burkert) and MOND. We find that, among the three models, the core-dominated Burkert halo model (

χ

ν

2

=
1.00

) provides a better description of the observed data than the NFW model (

χ

ν

2

=
1.44

) or MOND model (

χ

ν

2

=
1.87

). This is not consistent with the most recent numerical simulations, which tend to favor some cuspy density profiles for HSB galaxies. For MOND, when we take a
0 as a free parameter, there is no obvious correlation between a
0 and disk central surface brightness at 3.6 μm of these HSB spiral galaxies, which is in line with the basic assumption of MOND that a
0 should be a universal constant, but is surprisingly not consistent with the results when LSB galaxies are included. Furthermore, our fittings give a
0 an average value of (0.74 ±0.45) ×10−8 cm s−2, which only marginally supports the standard value of a
0 (1.21 ×10−8 cm s−2). Since the standard value of a
0 is strongly supported when both HSB and LSB galaxies are included in the large SPARC sample, we conclude that our slightly smaller value of a
0 cannot be explained by the so called external field effect in MOND theory.
PhotoNs-GPU: A GPU accelerated cosmological simulation code
Authors: Wang Qiao , Meng Chen 
Published: December 2021

Abstract
We present a GPU-accelerated cosmological simulation code, PhotoNs-GPU, based on an algorithm of Particle Mesh Fast Multipole Method (PM-FMM), and focus on the GPU utilization and optimization. A proper interpolated method for truncated gravity is introduced to speed up the special functions in kernels. We verify the GPU code in mixed precision and different levels of theinterpolated method on GPU. A run with single precision is roughly two times faster than double precision for current practical cosmological simulations. But it could induce an unbiased small noise in power spectrum. Compared with the CPU version of PhotoNs and Gadget-2, the efficiency of the new code is significantly improved. Activated all the optimizations on the memory access, kernel functions and concurrency management, the peak performance of our test runs achieves 48% of the theoretical speed and the average performance approaches to ∼35% on GPU.
Multi-parameter identification of gratings measurement by Experimental Ray Tracing
Authors: Chen Li-Si , Hu Zhong-Wen , Jiang Hai-Jiao , Kang Hui-Min , Wang Chen-Zhong 
Published: December 2021

Abstract
A simple method for measuring grating groove density as well as its position and orientation is proposed based on the idea of ERT (Experimental Ray Tracing). Conventional methods only measure grating groove density with accuracy limited by its rotary stage and goniometer. The method proposed in the paper utilizes linear guides which could be calibrated to much higher accuracy. It is applicable to gratings of arbitrary surface profile or mosaic of a group of various gratings. Various measurement error sources are simulated by the Monte Carlo method and the results show high accuracy capability of grating parameters identification. A verification testing is performed. The accuracy dependency on main configuration parameters is evaluated. A method to expand measurement range by double wavelength is also discussed.
Observational results of MUSER during 2014–2019
Authors: Zhang Ming-Hui , Zhang Yin , Yan Yi-Hua , Wang Wei , Chen Lin-Jie , Tan Cheng-Ming , Ma Su-Li , Huang Jing , Chen Xing-Yao , Tan Bao-Lin , Zhou Zhichao , Liu Fei , Geng Li-Hong , Li Sha , Du Jing , Su Cang , Chen Zhi-Jun , Cheng Jun 
Published: December 2021

Abstract
The solar radio signal that can be received by the ground-based telescopes covers a wide frequency range, allowing us to monitor the complex physical processes occurred from the solar surface to the vast interplanetary space. MingantU SpEctral Radioheliograph (MUSER), as the latest generation of solar dedicated radio spectral-imaging instrument in the centimeter-decimeter wavelengths, has accumulated a large number of observational data since its commissioning observation in 2014. This paper presents the main observational results identified by MUSER from 2014 to 2019, including the quiet Sun and 94 solar radio burst events. We find that there are 81 events accompanied with Geostationary Operational Environmental Satellites (GOES) soft X-ray (SXR) flares, among which the smallest flare class is B1.0. There are 13 events without accompanying any recorded flares, among which the smallest SXR intensity during the radio burst period is equivalent to level-A. The main characteristics of all radio burst events are presented, which shows the powerful ability of MUSER to capture the valuable information of the solar non-thermal processes and the importance for space weather. This work also provides a database for further in-depth research.
On detecting stellar binary black holes via the LISA-Taiji network
Authors: Chen Ju , Yan Chang-Shuo , Lu You-Jun , Zhao Yue-Tong , Ge Jun-Qiang 
Published: December 2021

Abstract
The detection of gravitational waves (GWs) by ground-based laser interferometer GW observatories (LIGO/Virgo) reveals a population of stellar binary black holes (sBBHs) with (total) masses up to ∼ 150M
⊙, which are potential sources for space-based GW detectors, such as LISA and Taiji. In this paper, we investigate in details on the possibility of detecting sBBHs by the LISA-Taiji network in future. We adopt the sBBH merger rate density constrained by LIGO/VIRGO observations to randomly generate mock sBBHs samples. Assuming an observation period of 4 years, we find that the LISA-Taiji network may detect several tens (or at least several) sBBHs with signal-to-noise ratio (SNR) > 8 (or > 15), a factor 2 − 3 times larger than that by only using LISA or Taiji observations. Among these sBBHs, no more than a few that can merge during the 4-year observation period. If extending the observation period to 10 years, then the LISA-Taiji network may detect about one hundred (or twenty) sBBHs with SNR> 8 (or > 15), among them about twenty (or at least several) can merge within the observation period. Our results suggest that the LISA-Taiji network may be able to detect at least a handful to twenty or more sBBHs even if assuming a conservative SNR threshold (15) for “detection”, which enables multi-band GW observations by space and ground-based GW detectors. We also further estimate the uncertainties in the parameter estimations of the sBBH systems “detected” by the LISA-Taiji network. We find that the relative errors in the luminosity distance measurements and sky localization are mostly in the range of 0.05 − 0.2 and 1 − 100deg2, respectively, for these sBBHs.