bluuebunny/crossref_metadata_2025_split huggingface dataset:
An edge-cloud collaborative computing platform for building AIoT applications efficiently
Authors: Rong Guoping , Xu Yangchen , Tong Xinxin , Fan Haojun 
Published: July 2021

AbstractThe convergence of Artificial Intelligence (AI) and the Internet of Things (IoT), or AIoT, has breathed a new life into IoT operations and human-machine interactions. Currently, resource-constrained IoT devices usually cannot provide sufficient capability for data storage and processing so as to support building modern AI models. An intuitive solution is to integrate cloud computing technology into AIoT and exploit the powerful and elastic computing as well as the storage capacity of the servers on the cloud end. Nevertheless, the network bandwidth and communication latency increasingly become serious bottlenecks. The emerging edge computing can complement the cloud-based AIoT in terms of communication latency, and hence attracts more and more attention from the AIoT area. In this paper, we present an industrial edge-cloud collaborative computing platform, namely Sophon Edge, that helps to build and deploy AIoT applications efficiently. As an enterprise-level solution for the AIoT computing paradigm, Sophon Edge adopts a pipeline-based computing model for streaming data from IoT devices. Besides, this platform supports an iterative way for model evolution and updating so as to enable the AIoT applications agile and data-driven. Through a real-world example, we demonstrate the effectiveness and efficiency of building an AIoT application based on the Sophon Edge platform.
Inducing sterile pyramidal neuronal death in mice to model distinct aspects of gray matter encephalitis
Authors: Wilke Justus B. H. , Hindermann Martin , Moussavi Amir , Butt Umer Javed , Dadarwal Rakshit , Berghoff Stefan A. , Sarcheshmeh Aref Kalantari , Ronnenberg Anja , Zihsler Svenja , Arinrad Sahab , Hardeland Rüdiger , Seidel Jan , Lühder Fred , Nave Klaus-Armin , Boretius Susann , Ehrenreich Hannelore 
Published: July 2021

AbstractUp to one person in a population of 10,000 is diagnosed once in lifetime with an encephalitis, in 50–70% of unknown origin. Recognized causes amount to 20–50% viral infections. Approximately one third of affected subjects develops moderate and severe subsequent damage. Several neurotropic viruses can directly infect pyramidal neurons and induce neuronal death in cortex and hippocampus. The resulting encephalitic syndromes are frequently associated with cognitive deterioration and dementia, but involve numerous parallel and downstream cellular and molecular events that make the interpretation of direct consequences of sudden pyramidal neuronal loss difficult. This, however, would be pivotal for understanding how neuroinflammatory processes initiate the development of neurodegeneration, and thus for targeted prophylactic and therapeutic interventions. Here we utilized adult male NexCreERT2xRosa26-eGFP-DTA (= ‘DTA’) mice for the induction of a sterile encephalitis by diphtheria toxin-mediated ablation of cortical and hippocampal pyramidal neurons which also recruits immune cells into gray matter. We report multifaceted aftereffects of this defined process, including the expected pathology of classical hippocampal behaviors, evaluated in Morris water maze, but also of (pre)frontal circuit function, assessed by prepulse inhibition. Importantly, we modelled in encephalitis mice novel translationally relevant sequelae, namely altered social interaction/cognition, accompanied by compromised thermoreaction to social stimuli as convenient readout of parallel autonomic nervous system (dys)function. High resolution magnetic resonance imaging disclosed distinct abnormalities in brain dimensions, including cortical and hippocampal layering, as well as of cerebral blood flow and volume. Fluorescent tracer injection, immunohistochemistry and brain flow cytometry revealed persistent blood–brain-barrier perturbance and chronic brain inflammation. Surprisingly, blood flow cytometry showed no abnormalities in circulating major immune cell subsets and plasma high-mobility group box 1 (HMGB1) as proinflammatory marker remained unchanged. The present experimental work, analyzing multidimensional outcomes of direct pyramidal neuronal loss, will open new avenues for urgently needed encephalitis research.
Exploratory analysis of machine learning methods in predicting subsurface temperature and geothermal gradient of Northeastern United States
Authors: Shahdi Arya , Lee Seho , Karpatne Anuj , Nojabaei Bahareh 
Published: July 2021

AbstractGeothermal scientists have used bottom-hole temperature data from extensive oil and gas well datasets to generate heat flow and temperature-at-depth maps to locate potential geothermally active regions. Considering that there are some uncertainties and simplifying assumptions associated with the current state of physics-based models, in this study, the applicability of several machine learning models is evaluated for predicting temperature-at-depth and geothermal gradient parameters. Through our exploratory analysis, it is found that XGBoost and Random Forest result in the highest accuracy for subsurface temperature prediction. Furthermore, we apply our model to regions around the sites to provide 2D continuous temperature maps at three different depths using XGBoost model, which can be used to locate prospective geothermally active regions. We also validate the proposed XGBoost and DNN models using an extra dataset containing measured temperature data along the depth for 58 wells in the state of West Virginia. Accuracy measures show that machine learning models are highly comparable to the physics-based model and can even outperform the thermal conductivity model. Also, a geothermal gradient map is derived for the whole region by fitting linear regression to the XGBoost-predicted temperatures along the depth. Finally, through our analysis, the most favorable geological locations are suggested for potential future geothermal developments.
Clinical features, radiological profiles, pathological features and surgical outcomes of pituicytomas: a report of 11 cases and a pooled analysis of individual patient data
Authors: Cheng Jian-Hua , Nie Ding , Li Bin , Gui Song-Bai , Li Chu-Zhong , Zhang Ya-Zhuo , Cavallo Luigi Maria , Zhao Peng 
Published: July 2021

Abstract
Background
Pituicytoma is an extremely rare low-grade glial tumor that is closely related to the neurohypophysis axis. Most studies of pituicytomas include only several cases. To better understand this disease, we reviewed a series of cases of pituicytomas. The diagnosis and treatment of pituicytoma must be further elucidated.

Methods
Eleven patients with pituicytoma admitted to Beijing Tiantan Hospital from 2012 to 2019 were selected. The clinical features, including radiological and histological examination, surgical records and prognosis were reviewed. Sixty-eight other previously published cases of pituicytoma also were used to analyze the predictive factors for the results. The Cox regression model was used for univariate and multivariate analyses.

Results
Our patients included 5 males (45.5%) and 6 females (54.5%), with a mean age of 49.3 years. The tumor was located in the suprasellar region in 5 patients (45.5%), intrasellar region in 4 patients (36.4%), and intrasellar-suprasellar region in 2 patients (18.2%). All patients were misdiagnosed with other common tumors in the sellar region before the operation. During the operation, gross total resection (GTR) of the tumor was achieved in 6 patients (54.5%), and subtotal resection (STR) was achieved in 5 patients (45.5%). The mean progression-free survival (PFS) time was 29.82 months. Tumor progression after surgical resection occurred in 4 patients (36.4%). Among them, 60.0% of the patients (cases 4, 5, 7) with STR experienced progression, while 16.7% of the patients (case 2) with GTR experienced progression. Combined with the 68 cases in the literature, GTR was an independent risk factor for PFS time (P < 0.05).

Conclusions
Pituicytomas are more common in middle-aged people and the sellar region. The clinical manifestations of pituicytomas are different, but no diagnostic clinical features have been identified other than an abnormally abundant blood supply. Currently, GTR is the best approach for the treatment of pituicytomas. More patients and longer follow-up periods were needed to further elucidate the biological features of pituicytomas.
A prospective, randomized controlled, double-blinded study comparing dexmedetomidine and clonidine as an adjuvant to ropivacaine in femoral nerve block for postoperative analgesia in patients undergoing total knee arthroplasty
Authors: Suresh Aathira , Fultambkar Gajanan , Vijayanand B. , Nair Abhijit 
Published: July 2021

Abstract
Background
Total knee arthroplasty (TKA) causes significant postoperative pain, imposing a limitation on postoperative mobilization crucial in regaining joint function. Ultrasound (US)-guided femoral nerve block (FNB) in complex knee surgeries is associated with better pain scores and fewer hospital admissions. Alpha-2 (α2) adrenoreceptor agonists have been the recent focus of interest as additives to local anesthetic. We aimed to compare the equivalent dose of dexmedetomidine and clonidine as an adjuvant to ropivacaine in US-guided FNB in TKA. A prospective, randomized, controlled, double-blinded study was conducted involving 80 American Society of Anesthesiologists’ physical status (ASA-PS) I, II, and III patients scheduled to undergo TKA under subarachnoid block. Group 1 (n = 40) patients received 1 μg/kg dexmedetomidine and group 2 (n = 40) patients with 1 μg/kg clonidine as adjuvants added to 20 ml of 0.75% ropivacaine. Duration of postoperative analgesia, pain scores, sedation scores, hemodynamics, rescue analgesia requirement, complications, and patient satisfaction were compared.

Results
The total duration of analgesia in group 1 was better compared to group 2 (p < 0.001).
The patients were better sedated and the mean NRS scores were significantly lower (p < 0.05) in group 1 up to 24 h postoperatively. Total analgesic consumption was reduced in group 1, with a p value < 0.001. Patient satisfaction was significantly better (p < 0.001) in group 1 compared to group 2.

Conclusion
We conclude that dexmedetomidine added as an adjuvant in FNB increased the duration of analgesia when compared to clonidine with decreased NRS scores, reduced postoperative tramadol requirement, and better sedation and patient satisfaction.

Trial registration
Researchregistry6709, “Retrospectively registered” on 31 March 2021.
Thymic carcinoma with extrinsic occlusion of the left anterior descending artery: a distinctive case of myocardial infarction in a young woman
Authors: Ayuna Ahmed , Ahmad Saad , Alam Sjirjel , Abidin Nik 
Published: July 2021

AbstractBackgroundThymic epithelial tumour (TET) is the most common tumour affecting the anterior mediastinum in adults. The cardiac extension is often limited to the pericardium, and intracardiac extension is rare. We present a unique case of encasement and displacement of the left anterior descending coronary artery by the large mediastinal tumour leading to myocardial ischemia.Case presentationOur patient is a 28-year-old lady with stage 4 TET. She presented with acute chest pain associated with 12-lead ECG changes and a significant rise in serial troponin I. Multimodality cardiac imaging revealed encasement and displacement of the left anterior descending coronary artery by the large mediastinal tumour. CT-FFR demonstrates evidence of ischemia which would account for her acute presentation. Following detailed MDT discussions between cardiologists, oncologists and cardiothoracic surgeons, the decision was made to treat this lady with palliative chemotherapy. Given the extent of the tumour invasion and failure of the initial therapy, her prognosis and the outcome were poor.ConclusionsTET could cause atrial compression, myocardial infiltration, and invasion of the pulmonary and caval veins; however, to the best of our knowledge, this is the first case reported of coronary artery displacement and encasement by TET.
The Regulation of Circulating Hepatokines by Fructose Ingestion in Humans
Authors: Richter Michael M , Plomgaard Peter 
Published: July 2021

Abstract

Context
Fibroblast growth factor 21 (FGF21), follistatin, angiopoietin-like 4 (ANGPTL4), and growth differential factor 15 (GDF15) are regulated by energy metabolism. Recent findings in humans demonstrate that fructose ingestion increases circulating FGF21, with increased response in conditions of insulin resistance.

Objective
This study examines the acute effect of fructose and somatostatin on circulating FGF21, follistatin, ANGPTL4, and GDF15 in humans.

Methods
Plasma FGF21, follistatin, ANGPTL4, and GDF15 concentrations were measured in response to oral ingestion of 75 g of fructose in 10 young healthy males with and without a 15-minute infusion of somatostatin to block insulin secretion. A control infusion of somatostatin was also performed in the same subjects.

Results
Following fructose ingestion, plasma FGF21 peaked at 3.7-fold higher than basal concentration (P &lt; 0.05), and it increased 4.9-fold compared with basal concentration (P &lt; 0.05) when somatostatin was infused. Plasma follistatin increased 1.8-fold after fructose ingestion (P &lt; 0.05), but this increase was blunted by concomitant somatostatin infusion. For plasma ANGPTL4 and GDF15, no increases were obtained following fructose ingestion. Infusion of somatostatin alone slightly increased plasma FGF21 and follistatin.

Conclusion
Here we show that in humans (1) the fructose-induced increase in plasma FGF21 was enhanced when somatostatin was infused, suggesting an inhibitory role of insulin on the fructose-induced FGF21 increase; (2) fructose ingestion also increased plasma follistatin, but somatostatin infusion blunted the increase; and (3) fructose ingestion had no stimulating effect on ANGPTL4 and GDF15 levels, demonstrating differences in the hepatokine response to fructose ingestion.
Always leave the audience wanting more: An entertaining approach to stimulate engagement with health research among publics in coastal Kenya through ‘Magnet Theatre’
Authors: Sanga Gladys , Jao Irene , Mumba Noni , Mwalukore Salim , Kamuya Dorcas , Davies Alun 
Published: July 2021

Background: Magnet Theatre (MT), a form of participatory community theatre, is one of several public engagement approaches used to facilitate engagement between KEMRI-Wellcome Trust Research Programme (KWTRP) researchers and public audiences in Coastal Kenya. We describe how we used MT as an entertaining forum where audiences learn about research, and where researchers learn about how the public views research. Methods: Drama scripts depicting community interaction with different aspects of research were developed iteratively with research staff, a theatre company and community members. Six fortnightly theatre outreaches per site over two months, attracting a total of 1454 audience members were held in Mida, a rural village 30 km north of Kilifi; and in Mtwapa, a peri-urban town 45 km to the south. Audiences were presented with dramatized health research-related dilemmas and subsequently invited to enact their responses. Evaluation comprised, notes and observations from meetings, rehearsals and outreaches, transcripts from a review workshop with repeat audience members (n=21), a reflection meeting with KWTRP engagement staff (n=12), and a group discussion with the theatre company (n=9). Discussions were recorded, transcribed, translated to English and analysed using thematic approach. Results: Despite being costly in terms of time and expense, we argue that MT in public spaces can assist audience members to navigate ‘border-crossings’ between everyday contexts and scientific/research concepts. This can enable audiences to share their views and concerns and enact their responses to research-related dilemmas. Conclusions: While reporting on MT’s successes, drawing from literature on rumours, we acknowledge the limitations of individual engagement activities in providing long-term solutions to address alternative interpretations and rumours about research, in the context of local and global inequities. MT, however, presents an opportunity for researchers to express respect to public audiences through making research more accessible and providing opportunities to listen to public views and concerns.
From severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) to coronavirus disease 2019 (COVID-19): a systematic review of the quality and responsiveness of clinical management guidelines in outbreak settings
Authors: Lipworth Samuel , Rigby Ishmeala , Cheng Vincent , Bannister Peter , Harriss Eli , Cook Karen , Cai Erhui , Tattan Mais , Epie Terrence , Manoharan Lakshmi , Lambe Kate , Michelen Melina , Vila-Gilibets Anna , Hart Peter , Groves Helen , Dagens Andrew , Sigfrid Louise , Horby Peter 
Published: July 2021

Background: Clinical management guidelines (CMGs) can be useful tools to guide clinician’s decision making and enable consistent evidence-based high-quality care. Here, we assessed whether their objective quality has improved over time by considering CMGs for severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and from different timepoints for coronavirus disease 2019 (COVID-19). Methods: We performed a rapid literature review, quality assessment and focus group consultation. The Appraisal of Guidelines for Research and Evaluation (AGREE-II) tool was used to evaluate the quality of the CMGs. In total, six COVID-19 treatments were selected to assess the responsiveness of a subset of guidelines and their updates to 20th November 2020. We ran two sessions of focus groups with patient advocates to elicit their views on guideline development. Results: We included 37 COVID-19, six SARS, and four MERS CMGs. Evidence appraisals in CMGs generally focused on novel drugs rather than basic supportive care; where evidence for the latter was provided it was generally of a low quality. Most CMGs had major methodological flaws and there was no evidence of improvement in quality over time. CMGs scored lowest in the following AGREE-II domains: scope and purpose, editorial independence, stakeholder engagement, and rigour of development. Of the COVID-19 CMGs, only eight included specific guidance for the management of elderly patients and only ten for high-risk groups; a further eight did not specify the target patient group. Early in the pandemic, multiple guidelines recommended unproven treatments and whilst in general findings of major clinical trials were eventually adopted, this was not universally the case. Conclusions: The quality of most CMGs produced in coronaviridae outbreaks is poor and we have found limited evidence of improvement over time, highlighting that current development frameworks must be improved. PROSPERO registration: CRD42020167361 (17/02/2020)
Gênero, cuidado e envelhecimento: um estudo sobre um grupo de mulheres idosas praticantes de pilates em Buenos Aires (AR)
Authors: Bitencourt Silvana Maria 
Published: July 2021

O artigo investiga um grupo de mulheres idosas praticantes de pilates e tem como objetivo principal investigar como elas cuidam-se na contemporaneidade. A metodologia utilizada consistiu em um trabalho de campo e entrevistas semiestruturadas. Constatou-se que a grande maioria decidiu fazer atividades físicas por indicação médica. Contudo, a possibilidade de estar cuidando-se junto com outras mulheres contribui para despertarem para o autoconhecimento de seus corpos/emoções.
Exclusive breastfeeding practice and associated factors among rural mothers with 6–12-month-old children in west Oromia, Ethiopia
Authors: Nemera Bedasa , Merga Hailu 
Published: July 2021

Background/aims Despite the benefits of exclusive breastfeeding for children, the practice is not widespread in low-income countries, including Ethiopia, especially in rural settings. This study aimed to determine exclusive breastfeeding practice and associated factors among mothers with 6–12-month-old children in west Oromia, Ethiopia. Methods This cross-sectional study was conducted among 391 randomly selected mothers with 6–12-month-old children in Amuru, Ethiopia. Data on breastfeeding practice were collected using a structured questionnaire, adapted from the Ethiopian Health and Demographic Survey. Data were analysed using the Statistical Package for Social Sciences version 21. Factors that were significantly associated with exclusive breastfeeding at univariate analysis were then submitted to binary logistic regression, with P<0.05 considered significant. Results Of the 391 respondents, 48.1% of the mothers reported exclusively breastfeeding their children. Factors associated with exclusive breastfeeding were: mother aged 21–25 years old (adjusted odds ratio=5.1, P<0.0001), husband`s educational status (adjusted odds ratio=2.8, P<0.0001), owning a radio (adjusted odds ratio=2.8, P<0.0001), antenatal care attendance (adjusted odds ratio=9.2, P<0.0001), delivery at a health institution (adjusted odds ratio=4.3, P<0.0001) and initiating breastfeeding within an hour of birth (adjusted odds ratio=4.2, P<0.0001). Conclusions The exclusive breastfeeding rate was low among mothers in this study. Health education should be provided to mothers at the community and health facility level. The quality of maternity services provided at health facilities or in the community needs improvement by providing pre-service and in-service training to health workers. Moreover, facility-based birth and respectful care needs promotion.
Effects of imatinib on vascular insulin sensitivity and free fatty acid transport in early weight gain
Authors: Box Camiel V. J. , Sandhu Amandeep K. , Turaihi Alexander H. , Xiaoké Pan , Dallinga-Thie Geesje , Aman Jurjan , Eringa Etto C. 
Published: July 2021

Background
Vascular endothelial dysfunction is an essential part of the pathophysiology of type 2 diabetes and its complications. In type 2 diabetes, endothelial dysfunction is characterized by reduced insulin signaling and increased transendothelial transport of fatty acids (FA). As the Abl kinase inhibitor imatinib was previously shown to reverse type 2 diabetes and to inhibit VEGF signaling via Abl kinases, we studied the effect of imatinib on vascular insulin sensitivity and fatty acid transport in vivo and in vitro.

Methods
C57/BL6J mice were fed a chow diet or Western diet (WD), and received daily imatinib injections for two weeks. Insulin-mediated vasoreactivity of resistance arteries was studied using intravital microscopy, and metabolic insulin sensitivity using the hyperinsulinemic-euglycemic clamp. The effect of imatinib on triglyceride content in skeletal muscle and heart in vivo was also determined. In vitro, the effect of imatinib on fatty acid transport was studied in human umbilical vein endothelial cells (HUVECs) by evaluating the effect of imatinib on fluorescently labeled FA uptake both under basal and VEGF-B-stimulated conditions.

Results
Imatinib prevented the WD-induced weight gain in mice, independently from food intake. In line with this, imatinib enhanced insulin-mediated vasoreactivity of resistance arteries in the WD-fed mice. However, imatinib did not affect triglyceride content in muscle. In cultured endothelial cells, VEGF-B stimulation resulted in a time-dependent uptake of fatty acids in parallel with increased phosphorylation of the Abl kinase substrate Crk-like protein (CrkL) at Tyr207. Although imatinib effectively prevented VEGF-B-mediated Abl kinase activation, it had no effect on VEGF-B mediated endothelial FA uptake.

Conclusion
Imatinib prevents weight gain and preserves insulin-mediated vasodilation in WD-fed mice, but does not affect endothelial FA transport despite inhibiting VEGF-B signaling. The beneficial effect of imatinib on insulin-mediated vasodilation may contribute to the anti-diabetic effects of imatinib.