bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of musculoskeletal conditions among those in residential aged care in Australia
Authors: Gill Tiffany K. , Caughey Gillian E. , Wesselingh Steve , Inacio Maria C. 
Published: October 2021

AbstractObjectiveTo determine the prevalence of musculoskeletal conditions, co‐morbidity and functional limitations in older people in residential aged care in Australia and the association of musculoskeletal conditions with mortality.MethodsA retrospective cohort study using data from 490 325 people in the Registry of Senior Australians was conducted between 2004 and 2014. The association of co‐morbidity, health risk factors and functional limitations with musculoskeletal conditions was evaluated using logistic regression. Cox regression was used to examine the association with mortality.ResultsOverall, 40.2% [95% CI 40.1‐40.4]) of residents had a musculoskeletal condition, which was associated with limited social (OR 1.16 [95% CI 1.14‐1.19]) and domestic activities (OR 1.44 [95% CI 1.39‐1.49]). Residents with musculoskeletal conditions had a 15% lower risk of mortality (aHR 0.85 [95% CI 0.85‐0.86], P < 0.001) compared to residents without.ConclusionsThe presence of musculoskeletal conditions in older people in residential aged care negatively impacts activities of daily living and quality of life rather than mortality.
Business as usual during the COVID‐19 pandemic? Reflections on state‐wide trends in maternity telehealth consultations during lockdown in Victoria and New South Wales
Authors: Potenza Stephanie , Marzan Melvin Barrientos , Rolnik Daniel Lorber , Palmer Kirsten , Said Joanne , Whitehead Clare , Sheehan Penelope , Mol Ben W. , Walker Susan , Hui Lisa 
Published: October 2021

AbstractCOVID‐19 has resulted in unprecedented changes to maternity care across Australia. This study aims to analyse trends in maternity consultations and the uptake of telehealth in Victoria and New South Wales (NSW) since the first restrictions to reduce COVID‐19 transmission were implemented. From March 2020 to April 2021, a higher proportion of antenatal care consultations was delivered via telehealth in Victoria compared to NSW (13.8% vs 7.4%, P < 0.0001). Uptake of telehealth and a shift from in‐person care has been a major contributor to maintaining pregnancy care during pandemic restrictions. However, further research is required to understand women’s perspectives and health outcomes.
Importance of attachment to place in growing a sustainable Australian Rural Health Workforce: A rapid review
Authors: Beccaria Lisa , McIlveen Peter , Fein Erich C. , Kelly Tricia , McGregor Rowena , Rezwanul Rana 
Published: October 2021

AbstractIntroductionPersonal, community, and environmental factors can influence the attraction and retention of regional, rural, and remote health workers. However, the concept of place attachment needs further attention as a factor affecting the sustainability of the rural health workforce.ObjectiveThe purpose of this rapid review was to explore the influence of a sense of place in attracting and retaining health professionals in rural and remote areas.DesignA systematic rapid review was conducted based on an empirical model using four dimensions: place dependence, place identity, social bonding and nature bonding. English‐language publications between 2011 and 2021 were sought from academic databases, including studies relevant to Australian health professionals.FindingsA total of 348 articles were screened and 52 included in the review. Place attachment factors varied across disciplines and included (a) intrinsic place‐based personal factors; (b) learning experiences enhancing self‐efficacy and rural health work interest; (c) relational, social and community integration; and (d) connection to place with lifestyle aspirations.DiscussionThis rapid review provides insight into the role of relational connections in building a health workforce and suggests that community factors are important in building attachment through social bonding and place identity. Results indicate that future health workforce research should focus on career decision‐making and psychological appraisals including place attachment.ConclusionAn attachment to place might develop through placement experiences or from a strong rural upbringing. The importance of the relational interactions within a work community and the broader community is seen as an important factor in attracting, recruiting, and sustaining a rural health workforce.
Impact of upper blepharoplasty, with or without orbicularis oculi muscle removal, on tear film dynamics and dry eye symptoms: A randomized controlled trial
Authors: Hollander Maria H. J. , Pott Jan Willem R. , Delli Konstantina , Vissink Arjan , Schepers Rutger H. , Jansma Johan 
Published: October 2021

AbstractPurposeUpper blepharoplasty may be related to dry eye symptoms since the function of the orbicularis oculi muscle may affect the tear film. We aimed to assess the effect of blepharoplasty with or without the removal of a strip of orbicularis oculi muscle on tear film dynamics and dry eye symptoms.MethodsA double‐blind, randomized, controlled trial comparing upper blepharoplasty without (group A) or with (group B) orbicularis oculi muscle excision was performed on 54 healthy Caucasian patients. Tear film dynamics and dry eye symptoms were evaluated using multiple dry eye parameters, i.e. tear osmolarity, Schirmer test I, corneal/conjunctival staining, tear break‐up time (TBUT), Oxford Scheme, Sicca Ocular Staining Score and Ocular Surface Disease Index questionnaire. All the parameters were assessed preoperatively and 6 and 12 months after upper blepharoplasty. All the groups’ outcomes were compared.ResultsThe differences were not significant between the two upper blepharoplasty techniques regarding most of the above‐mentioned outcomes. Subjective symptoms of ocular irritation, consistent with dry eye disease and vision‐related impairment, were reduced after upper blepharoplasty independent of the type of the technique applied, while the pre and postoperative outcomes of the objective tear dynamics did not differ 12 months after surgery. However, group B demonstrated a significant increase in tear osmolarity and TBUT at the 6‐month follow‐up visit.ConclusionAn upper blepharoplasty alleviates subjective dry eye complaints in the long term, while not changing the tear dynamics. The improvement was independent of the blepharoplasty technique used.
Lavender aromatherapy: A systematic review from essential oil quality and administration methods to cognitive enhancing effects
Authors: Malloggi Eleonora , Menicucci Danilo , Cesari Valentina , Frumento Sergio , Gemignani Angelo , Bertoli Alessandra 
Published: October 2021

AbstractModern society is reviving the practice of aromatherapy, and lavender is reported being the most worldwide purchased plant for essential oil (EO) extraction. Since recent studies reported cognitive enhancing effects of lavender besides the hypno‐inducing effects, a literature review is needed. Considering EO quality and diffusion devices, we conducted a systematic review on the effects of lavender EO inhalation on arousal, attention and memory in healthy subjects. Starting from this new multidisciplinary perspective, cognitive effects were reviewed to link outcomes to effective and reproducible protocols. A systematic search on MEDLINE, ERIC, PsycInfo, Google Scholar, and Scopus databases using Cognitive Atlas and plant‐related keywords was conducted. Among the 1,203 articles yielded, 11 met eligibility criteria. Subjects administered with lavender EO displayed arousal decrease and sustained attention increase. Controversial results emerged regarding memory. Lack of EO quality assessment and protocols heterogeneity did not allow assessing whether different EO composition differentially modulates cognition and whether placebo effect can be discerned from EO effect itself. However, GABAergic pathway modulation exerted by linalool, a major lavender EO constituent, might explain cognitive functions empowerment. We speculate aromatherapy could be a burgeoning cognition enhancing tool, although further investigation is required to reach robust conclusions.
Road verges facilitate exotic species’ expansion into undisturbed natural montane grasslands
Authors: Turner Sophia Carmel , Esler Karen Joan , Kalwij Jesse Machiel 
Published: October 2021

AbstractQuestionsHow has exotic plant species richness and composition changed in and adjacent to a montane road verge over a 10‐year period? Are montane road verges conduits of exotic species’ dispersal into adjacent, undisturbed hinterland?LocationMontane grassland, Maloti‐Drakensberg Transfrontier Conservation Area, South Africa.MethodsWe surveyed road verge and adjacent hinterland transects (25 × 2 m; N = 80) across an elevational gradient of 1,500–2,874 m a.s.l. in 2007 and 2017. In each transect, we estimated the cover of each exotic plant species and the total cover of indigenous species. Generalised Linear Models were fitted to test if exotic species’ richness and cover had changed over time. A Canonical Correspondence Analysis was used to determine if exotic species’ composition had changed over time.ResultsTen years onwards, exotic species richness had increased significantly across the entire elevational gradient, predominantly in the low‐ to mid‐elevational range. Road verge and adjacent hinterland transects differed in species composition in 2007, but no longer in 2017.ConclusionExotic species richness and composition displayed a high spatiotemporal rate of change. Over time, exotic species increasingly moved into the hinterland from the verges as a result of human‐mediated colonisation pressure. These results indicate that montane road verges are far better conduits for the dispersal of exotic species than previously assumed, and that further colonisation of the hinterland by exotics can be expected.
Antihypertensive drug use and psoriasis: A systematic review, meta‐ and network meta‐analysis
Authors: Song Gonjin , Yoon Ha Young , Yee Jeong , Kim Myeong Gyu , Gwak Hye Sun 
Published: October 2021

AimsDiverse genetic and/or external factors may induce psoriasis. Drug exposure is 1 such prominent external factor; antihypertensive drugs are reportedly associated with psoriasis, but study results have been inconsistent. In this context, we investigated the associations between antihypertensive drugs and incidence if psoriasis via a systematic literature review and meta‐analysis.MethodsLiterature search in databases such as PubMed, Embase and Web of Science was conducted on 8 January 2021, and obtained data were pooled for meta‐ and network meta‐analysis. Fixed‐ or random effect models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for evaluating the strength of the associations between antihypertensive drugs and psoriasis incidence. In addition to meta‐analysis, Bayesian network meta‐analysis was performed.ResultsThirteen eligible studies were included for meta‐analysis with 6 378 116 individuals and 8 studies for network meta‐analysis with 5 615 918 individuals. All antihypertensive drugs were significantly associated with psoriasis incidence. In a meta‐analysis, the pooled ORs were 1.67 (95% CI: 1.31–2.13) for angiotensin‐converting enzyme (ACE) inhibitors, 1.40 (95% CI: 1.20–1.63) for β‐blockers, 1.53 (95% CI: 1.23–1.89) for calcium‐channel blockers (CCBs), and 1.70 (95% CI: 1.40–2.06) for thiazide diuretics. For the comparative risks of psoriasis among antihypertensive drugs in the network meta‐analysis, ORs were 2.09 (95% CI: 1.39–3.18) for ACE inhibitors, 1.35 (95% CI: 0.99–1.91) for BBs, 1.53 (95% CI: 1.07–2.24) for CCBs and 1.80 (95% CI: 1.23–2.66) for thiazide diuretics.ConclusionThis study confirmed the associations between antihypertensive drugs and psoriasis; ACE inhibitors, BBs, CCBs and thiazide diuretics increased the risk of psoriasis. Therefore, antihypertensive drug users should be carefully monitored for psoriasis.
Intensified antiplatelet therapy in patients after percutaneous coronary intervention with high on‐treatment platelet reactivity: the OPTImal Management of Antithrombotic Agents (OPTIMA)‐2 Trial
Authors: Ying Lianghong , Wang Jing , Li Juan , Teng Jianzhen , Zhang Xiaofeng , Ullah Inam , Samee Abdus , Xu Ke , Chen Jun , Xu Lei , Zhu Hui , Li Jimin , Yang Lu , Wang Fei , Fan Yuansheng , Zhang Jing , Lu Yi , Gong Xiaoxuan , Shi Lu , Eikelboom John W. , Li Chunjian 
Published: October 2021

SummaryHigh on‐treatment platelet reactivity (HOPR) is associated with increased risk of cardiovascular events in patients undergoing percutaneous coronary intervention (PCI). We randomised post‐PCI patients with HOPR after 5 days of standard dual antiplatelet therapy (DAPT) to intensified therapy with aspirin 100 mg once daily in combination with either clopidogrel 150 mg once daily, clopidogrel 75 mg once daily plus cilostazol 100 mg twice daily, ticagrelor 90 mg twice daily, or standard therapy with clopidogrel 75 mg once daily (STD) for 1 month, after which all patients were switched to standard DAPT for a further 11 months. The primary outcome was residual HOPR rate at 1 month. We screened 1724 patients with light transmission aggregation studies and randomised 434 with HOPR. At 1 month the proportion of patients with persistent HOPR was significantly lower in the intensified therapy groups compared with STD group. Compared to the group receiving STD therapy, those receiving intensified therapy had significantly lower rate of major adverse cardiovascular events (MACE) at both 1 month and 12 months with no significant increase in bleeding. In patients with post‐PCI HOPR, 1 month of intensified antiplatelet therapy provides greater platelet inhibition and improves outcomes without increasing bleeding.Clinical Trial Registration URL: http://www.clinicaltrials.gov; Unique Identifier: NCT01955200.
Novel therapies for immune thrombocytopenia
Authors: Kuter David J. 
Published: October 2021

SummaryCurrent therapies for immune thrombocytopenia (ITP) are successful in providing a haemostatic platelet count in over two‐thirds of patients. Still, some patients have an inadequate response and there is a need for other therapies. A number of novel therapies for ITP are currently being developed based upon the current pathophysiology of ITP. Many therapies are targetted at reducing platelet destruction by decreasing anti‐platelet antibody production by immunosuppression with monoclonal antibodies targetted against CD40, CD38 and the immunoproteasome or physically reducing the anti‐platelet antibody concentration by inhibition of the neonatal Fc receptor. Others target the phagocytic system by inhibiting FcγR function with staphylococcal protein A, hypersialylated IgG, polymeric Fc fragments, or Bruton kinase. With a recognition that platelet destruction is also mediated by complement, inhibitors of C1s are also being tested. Inhibition of platelet desialylation may also play a role. Other novel therapies promote platelet production with new oral thrombopoietin receptor agonists or the use of low‐level laser light to improve mitochondrial activity and prevent megakaryocyte apoptosis. This review will focus on these novel mechanisms for treating ITP and assess the status of treatments currently under development. Successful new treatments for ITP might also provide a pathway to treat other autoimmune disorders.
The effect of work‐schedule control on volunteering among early career employees
Authors: Mantovan Noemi , Sauer Robert M. , Wilson John 
Published: October 2021

AbstractRecent trends in the labor market see increasing numbers of workers having to deal with ‘schedule precarity’ including volatile hours, rotating shift work, unpredictable work hours and lack of choice on the part of the employee. These trends are of concern to those interested in fostering levels of civic engagement because they potentially limit volunteering. This study uses data from the National Longitudinal Survey of Youth 1997 (NLSY97) containing information on work schedules in 2011 and 2013 among employees to determine the effect of changes in work schedules on becoming a volunteer using transition regressions. We investigate interactions between work‐schedule measures and pay structure because workers paid by the hour have lower volunteer rates than salaried workers. The study finds that, while three of the schedule dimensions are unrelated to volunteering, transitioning toward more schedule control has a positive effect on volunteering. However, interaction analysis shows this positive effect is confined to salaried workers whereas for hourly paid workers the effect is negative. The results support the idea that having more freedom to set one's work schedule reduces work‐life conflict but suggest that this positive effect is limited to those who can take advantage of it.
Hydroxycinnamic acid‐spermidine amides from Tetragonisca angustula honey as anti‐Neospora caninum: In vitro and in silico studies
Authors: Lima Ângela C. de O. , Conceição Rodrigo S. , Freitas Luciana S. , de Carvalho Carlos A. L. , Conceição Antônio L. da S. , Freitas Humberto F. , Pita Samuel S. da R. , Ifa Demian R. , Pinheiro Alexandre M. , Branco Alexsandro 
Published: October 2021

AbstractTetragonisca angustula honey was fractioned in a SiO2 column to furnish three fractions (A–C) in which four hydroxycinnamic acid‐Spermidine amides (HCAAs), known as N′, N″, N‴—tris‐p‐coumaroyl spermidine, N′, N″—dicaffeoyl, N‴—coumaroyl spermidine, N′, N″, N‴—tris‐caffeoyl spermidine and N′, N″—dicaffeoyl and N‴—feruloyl spermidine were identified in the fractions B and C by electrospray ionization tandem mass spectrometry. A primary culture model previously infected with Neospora caninum (72 h) was used to evaluate the honey fractions (A–C) for two‐time intervals: 24 and 72 h. Parasitic reduction ranged from 38% on fraction C (12.5 µg/ml), after 24 h, to 54% and 41% with fractions B and C (25 µg/ml) after 72 h of treatment, respectively. Additionally, HCAAs did not show any cell toxicity for 24 and 72 h. For infected cultures (72 h), the active fractions B (12.5 µg/ml) and C (25 µg/ml) decreased their NO content. In silico studies suggest that HCAAs may affect the parasite's redox pathway and improve the oxidative effect of NO released from infected cells. Here, we presented for the first time, that HCAAs from T. angustula honey have the potential to inhibit the growth of N. caninum protozoa.
Genetics of pubertal delay
Authors: Saengkaew Tansit , Howard Sasha R. 
Published: October 2021

AbstractThe timing of pubertal development is strongly influenced by the genetic background, and clinical presentations of delayed puberty are often found within families with clear patterns of inheritance. The discovery of the underlying genetic regulators of such conditions, in recent years through next generation sequencing, has advanced the understanding of the pathogenesis of disorders of pubertal timing and the potential for genetic testing to assist diagnosis for patients with these conditions. This review covers the significant advances in the understanding of the biological mechanisms of delayed puberty that have occurred in the last two decades.
Global corporate social responsibility reporting regulation
Authors: Wen Hui , Deltas George 
Published: October 2021

AbstractCorporate social responsibility (CSR) has steadily grown in importance. We show government regulation on corporate reporting of CSR, aimed to spur its growth and increase transparency, has grown in tandem. Such reporting regulation is more readily observable than CSR itself and can be used as a proxy for the latter. We show that larger economies with higher institutional capacity find it easier to develop reporting regulations, and that international influences and local pollution increase concerns are important contributing factors. We show that such regulation also increases CSR, even after accounting for common unobserved factors that may affect both.
Understanding Miscommunication: Speech Act Recognition in Digital Contexts
Authors: Holtgraves Thomas 
Published: October 2021

AbstractSuccessful language use requires accurate intention recognition. However, sometimes this can be undermined because communication occurs within an interpersonal context. In this research, I used a relatively large set of speech acts (n = 32) and explored how variability in their inherent face‐threat influences the extent to which they are successfully recognized by a recipient, as well as the confidence of senders and receivers in their communicative success. Participants in two experiments either created text messages (senders) designed to perform a specific speech act (e.g., agree) or interpreted those text messages (receivers) in terms of the specific speech act being performed. The speech acts were scaled in terms of their degree of face threat. In both experiments, speech acts that were more threatening were less likely to be correctly recognized than those that were less threatening. Additionally, the messages of the more threatening speech acts were longer and lower in clout than the less threatening speech acts. Senders displayed greater confidence in communicative success than receivers, but judgments of communicative success (for both senders and receivers) were unrelated to actual communicative success. The implications of these results for our understanding of actual communicative episodes are discussed.
Draw a Star and Make it Perfect: Incremental Processing of Telicity
Authors: Foppolo Francesca , Bosch Jasmijn E. , Greco Ciro , Carminati Maria N. , Panzeri Francesca 
Published: October 2021

AbstractPredicates like “coloring‐the‐star” denote events that have a temporal duration and a culmination point (telos). When combined with perfective aspect (e.g., “Valeria has colored the star”), a culmination inference arises implying that the action has stopped, and the star is fully colored. While the perfective aspect is known to constrain the conceptualization of the event as telic, many reading studies have demonstrated that readers do not make early commitments as to whether the event is bounded or unbounded. A few visual‐world studies tested the processing of telic predicates during online sentence processing, demonstrating an early integration of aspectual and temporal cues. By employing the visual‐world paradigm, we tested the incremental processing of the perfective aspect in Italian in two eye‐tracking studies in which listeners heard durative predicates in the perfective form in a scenario showing a completed and a non‐completed event. Differently from previous studies, we compared telic durative predicates such as “coloring‐the‐star” to punctual predicates such as “lighting‐the‐candle.” While for punctual predicates, the inferences of telicity (the event has a telos) and of culmination (the telos is reached) are lexically encoded in the perfective verb, for durative predicates, the degree of event completion (visually encoded) needs to be integrated with perfective aspect (linguistically encoded) for the culmination inference derivation. By modulating the interaction of visual and linguistic stimuli across the two experiments, we show that the verb's perfective aspect triggers the culmination inference incrementally during sentence processing, offering novel evidence for the continuous integration of linguistic processing with real‐world visual information.