bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of Neural Tube Defect: A Single-Center Experience
Authors: Söylemez Burçak , Bulut Zekeriya , Koç Fatih , Özüm Ünal , Karadağ Özen 
Published: March 2021

Objective: Neural tube defects are a heterogeneous and complex group of congenital central nervous system anomalies involving that involve the failed closure of the vertebral column. The spinal cord is frequently affected, and neural tube defects substantially increase the risk of disability and death within the first year of life. Neural malformations are often associated with abnormalities in other organ systems. This study presents our clinical experiences regarding the development and comorbidities of infants with neural tube defect and compares them with the literature.
Materials and Methods: This retrospective study included 47 patients (24 females, 23 males) who underwent surgical treatment for neural tube defect in the neurosurgery department of Sivas Cumhuriyet University Faculty of Medicine Training and Research Hospital between 2000 and 2020.
Results: Of the 47 patients, 34 (72.34%) had myelomeningocele and 13 (27.65%) had meningocele. Lesion location was thoracolumbar in 38 patients (80.85%), lumbar in 5 (10.63%), lumbosacral in 3 (6.38%), and cervical in 1 patient (2.12%). Twenty-seven patients (57.44%) underwent ventriculoperitoneal shunting due to hydrocephalus. Thirty patients (63.82%) had Chiari malformation type II, 13 (27.65%) had cranial anomalies, and 1 (2.12%) had Down syndrome. In 9 patients, the conus medullaris terminated at or below the L3 vertebral body (19.14%). Two patients (4.25%) died.
Conclusion: Because of their multidimensional nature, neural tube defects have various effects on individuals, families, society, and the field of medicine. This study represents a small group of patients with neural tube defects. Cases should be included from other centers to compile more comprehensive data about patients with neural tube defects in Turkey.
The Relationship Between the Level of Revanchist Behavior and Emotional State and Sleep Quality
Authors: Fidancı İzzet , Aksoy Hilal , Ayhan Başer Duygu , Yengil Taci Duygu , Cankurtaran Mustafa 
Published: March 2021

Objective: The aim of this study is to examine factors that can affect revanchist behavior such as emotional state and sleep quality, and to evaluate the relationship between them.
Materials and Methods: 461 individuals at the age of 18 and above who referred to our polyclinic for any reason, and agreed to participate were included in the study via conducting a survey after their written consents were obtained. A survey that consisted of socio-demographic information in the first section, and “the Vengeance Scale”, “the Pittsburgh Sleep Quality Index”, “the State-Trait Anxiety Inventory” and “Beck Depression Inventory” in the second section was applied to the participants. The data were analyzed with IBM SPSS V23.
Results: 52.7% of the participants were male and 47.3% were female. The mean age of the study group was 37.4 ± 11.2 years. 51.4% of the participants had severe depression according to the Beck Depression Inventory, while 20.4% had moderate, 16.3% had minimal and 11.9% had mild depression. The median value of the revanchist behavior levels did not differ according to gender (p=0.257). The median value of the revanchist behavior levels in males were 82, while it was 75 in female participants. The median value of the revanchist behavior levels did not differ according to the educational background (p=0.727). A statistically significant relationship was not found between revanchist behavior levels and age, state anxiety, trait anxiety, Beck depression point and PSQI (p>0.05).
Conclusion: The absence of a significant relationship between revenge behavior and age, anxiety level, depression and sleep quality will help us to improve the quality of life of societies rather than personal psychological characteristics, and this behavior level that can also cause violence will be minimized.
НОРМАТИВНО-ПРАВОВЕ ЗАБЕЗПЕЧЕННЯ РОЗВИТКУ МАТЕРІАЛЬНО-ТЕХНІЧНОГО ПОТЕНЦІАЛУ ЄДИНОЇ ДЕРЖАВНОЇ СИСТЕМИ ЦИВІЛЬНОГО ЗАХИСТУ
Authors: Подобед Ігор 
Published: March 2021

Практика реагування на надзвичайну ситуацію, що пов’язана із розповсюдженням захворюваності населення COVID-19, свідчить, що ефективність функціонування Єдиної державної системи цивільного захисту в повсякденному режимі, а особливо при переведенні її в режим надзвичайної ситуації залежить від наявності в неї відповідного ресурсного потенціалу.
Метою статті є аналіз стану нормативно-правового забезпечення розвитку матеріально-технічного потенціалу ЄДСЦЗ. На основі аналізу різних методологічних підходів державного управління сферою цивільного захисту перспективним запропоновано застосування ресурсного підходу до функціонування ЄДСЦЗ. Це дозволяє враховувати прогнози щодо її розвитку, прогнозувати застосування нових та альтернативних видів ресурсів.
Подається авторське розуміння дефініцій «ресурс», «потенціал», «ресурсний потенціал», «матеріально-технічний ресурс». У статті дано авторське визначення ресурсного потенціалу ЄДС ЦЗ як комплексу науково-технічного, морального, організаційного, кадрового, фінансового, матеріально-технічного, освітнього, інформаційного, інституційного (соціально-інфраструктурного) потенціалу, що може бути застосований органами управління для виконання її функцій. Матеріально-технічний ресурс (потенціал) розуміється як сукупність матеріальних і технічних засобів, технологій, систем, що створюють систему ресурсного забезпечення функціонування ЄДСЦЗ. По суті матеріально-технічний ресурс складається із поточного ресурсу, що використовуються ЄДСЦЗ, а також матеріальних резервів, що відповідно до законодавства поділяються на оперативний, відомчий, регіональний та об’єктовий. Також для виконання завдань ліквідації наслідків надзвичайних ситуацій може залучатися державний матеріальний резерв. Визначено, що нормативно-правове забезпечення розвитку матеріально-технічного потенціалу ЄДСЦЗ в достатній мірі регламентовано. Однак встановлено, що фактичний стан матеріально-технічного ресурсу ЄДСЦЗ не забезпечує вчасного, належного забезпечення реалізації заходів із запобігання чи ліквідації наслідків в умовах надзвичайних ситуацій. Критеріями оцінювання стану розвитку ресурсного потенціалу ЄДСЦЗ є доцільність і ефективність використання будь-яких із наявних ресурсів, ефективність управління на всіх рівнях – державному, функціональному, територіальному, об’єктовому.
Напрямом подальшого визначено розробка алгоритму розрахунку рівня ефективності управління розвитком ресурсного потенціалу ЄДСЦЗ.
The The Role Of Von Willenbrand Factors As The Early Detection Of Endotel Cell Damage In Youth Ages With Obesity In The Usu Medan Campus Environment
Authors: Rusdiana  , Syahputra Muhammad , Suryani Sry 
Published: March 2021

Preliminary : Endothelial cells are a single layer that lines the entire vascular system. Endothelial dysfunction can be triggered by several main things, namely physical stress, oxidative stress and irritant substances. Obesity triggers an inflammatory process and metabolic disorders that will lead to increased oxidative stress. Long-term oxidative stress will cause damage to cells and tissues and trigger degenerative diseases. Damage to endothelial cells is expected to be detected by examining Von Willenbrand levels so that it can prevent complications of vascular disorders early.
Method: This research is descriptive with cross sectional design. Carried out from March to October 2018 on the USU Campus. The first examination was done to measure body weight and height to determine body mass index, then performed lipid profile and blood sugar levels (KGD) in the sample, then examined von Willenbrand factor levels carried out in the integrated laboratory of USU FK using the method ELISA in both the sample group and the control group. The research subjects were adolescents aged 17-25 years with BMI> 25 kg / m2Data analysis was carried out using the T-Test statistical program, comparing two groups.
Result: Of the 40 obese subjects found Von Wilenbrand level values ​​The lowest factor was 1.78 IU / ml and the highest was 35.60 IU / ml. Whereas in 40 non-obese subjects Von Wilenbrand grade values ​​were the lowest factor of 2.01 IU / ml and the highest was 45.10 IU / ml. This difference was not statistically significant (p = 0.661).Conclusion: There was no significant difference between the levels of Von Wilenbrand Factors in obese subjects with non-obese subjectsKey Words: Obesity, endothelial cells, Von Wilenbrand Factors
Analisis model-model pembelajaran fikih yang aktual dalam merespons isu sosial di sekolah dan madrasah
Authors: Mansir Firman 
Published: March 2021

<p class="15bIsiAbstractBInggris"><em>This study describes the learning of fikih in schools in various models, methods or strategies, and approaches that have a significant role in achieving the goals of learning efforts and responding to various problems in society. Therefore, the method becomes a way and a tool guide in order to achieve learning with a goal that can produce various materials and concepts of fikih that can be arranged in the Islamic religious education curriculum. With the existence of inappropriate fikih learning models, approaches and strategies will be an obstacle to the smooth running of learning at this stage of the process. Thus, an educator needs to have skills in choosing the right model, strategy and approach according to the characteristics of subjects and students. These models, strategies, and approaches will only get optimal results if they can be used to achieve the stated goals. To achieve various learning objectives, one thing that needs to be considered and applied is to consistently use models, strategies and learning approaches that are in accordance with the conditions in schools and madrasa. This research is in the form of literature study, namely research with the source of material from the library. So that, what is, done in making this research is exploration of some data.</em></p><p class="15cKeywordsBInggris"> </p><p class="16aJudulAbstrak"><strong>Abstrak</strong></p><p class="16bIsiAbstrak">Penelitian ini menjelaskan tentang pembelajaran fikih di sekolah dalam berbagai model, metode atau strategi, dan pendekatan yang memiliki andil signifikan dalam tujuan tercapai upaya pembelajaran serta merespons berbagai persoalan di masyarakat. Karena itu metode menjadi jalan dan petunjuk alat agar mencapai pembelajaran dengan tujuan yang dapat menghasilkan berbagai bahan dan konsep fikih yang dapat diatur pada kurikulum Pendidikan agama Islam. Dengan adanya model, pendekatan dan strategi pembelajaran fikih yang tidak sesuai akan menjadi penghambat kelancaran pembelajaran pada tahap prosesnya. Dengan demikian, seorang pendidik perlu memiliki keterampilan dalam memilih model, strategi dan pendekatan yang tepat sesuai dengan karakteristik mata pelajaran dan peserta didik. Model, strategi, dan pendekatan ini hanya akan mendapatkan hasil yang optimal jika dapat digunakan untuk mencapai tujuan yang telah ditetapkan. Untuk meraih berbagai tujuan pembelajaran, maka salah satu yang perlu diperhatikan dan diterapkan adalah dengan konsisten memakai model, strategi dan pendekatan pembelajaran yang sesuai dengan kondisi di sekolah dan madrasah. Penelitian ini berupa studi kepustakaan, yaitu penelitian dengan sumber bahan dari perpustakaan. Sehingga yang dilakukan dalam pembuatan penelitian ini yaitu eksplorasi terhadap beberapa data.</p>
ДОСЛІДЖЕННЯ ДИНАМІЧНОГО НАВАНТАЖЕННЯ ТРАКТОРІВ З ОБ’ЄМНИМ ГІДРАВЛІЧНИМ ПРИВОДОМ
Authors: Mandryka V.R. , Krasnokutskyi V.M. , Ostroverkh O.O. 
Published: March 2021

Процеси, що виникають у трансмісіях тракторних агрегатів та самохідних сільськогосподарських машин за різних режимів руху і в процесі регулювання, характеризуються складними залежностями, які вивчаються аналітично або експериментально. Відомі різні способи отримання математичних моделей. Одним із них є класичний метод прямого опису. Іншим – використання пасивних і активних методів регресійного аналізу. Раціональним є використання обох методів, поєднання яких дає можливість отримати необхідну математичну модель. Об’ємний гідропривід (ОГП) все більше знаходить застосування в трансмі- сіях сучасних тракторів і самохідних сільськогосподарських машин. У наведеній статті розглядається математичний опис аксіально-поршневих гідромашин. Проведено дослідження перехідних процесів, їх оцінка проводилися для визна- чення навантажень, що виникають у трансмісії машини за ступінчастої зміни навантаження, передавального числа ОГП і постійної подачі палива під час роз- гону агрегату з місця. Режим розгону агрегату вивчався під час руху на оран- ці і на транспортних роботах для таких параметрів і таких початкових умов: швидкість обертання валу гідромотора і валу двигуна; крутний момент на валу двигуна; Крюкова навантаження; тиск у напірній магістралі ОГП. Враховано динамічні характеристики гідромашин, витоку рідини і її пружні властивості, а також змінні значення ККД гідроприводу. Результати моделювання зіставлені з експериментальними дослідженнями. Як об’єкти дослідження використовува- лися: макет гусеничного трактора Т-150Е з незалежними повнопотоковий ОГП лівого і правого бортів; макет колісного коренезбирального комбайна з незалеж- ними ОГП бортів задніх ведучих коліс. Залежно від режимів роботи за несталого руху можливі такі варіанти управління, що забезпечують високу швидкодію за деякого рівня динамічних навантажень або мінімальні динамічні навантаження, коли часовий чинник не є превалюючим. Перспективним є й оптимальне управлін- ня, коли у функцію мети включені додаткові параметри.
Morpho-Molecular Characterization and Screening of Rice (Oryza Sativa L.) Genotypes for Salinity Tolerance at Seedling Stage
Authors: Muti SAA , Hoque MI , Islam MM , Siddique MA , Islam MS 
Published: March 2021

Salinity is one of the major abiotic stresses which severely affect the production of crops across the world. Twenty rice genotypes of diverse origins were assessed to examine salt tolerance potentiality at seedling stage as well as to elucidate the genetic variation using SSR markers. Consequently, IRRI standard protocol was applied to screen out those varieties for tolerance at the glasshouse laboratory of Bangladesh Institute of Nuclear Agriculture, maintaining salt stress level at 6dS m-1, 8dS m-1, 10dS m-1 and 12 dS m-1. Data on morphological parameter were recorded as shoot length (cm), root length (cm) and total dry matter (TDM). For molecular characterization thirteen SSR markers were exploited to determine the genetic diversity and in this context, 53alleles were revealed while the mean number of alleles per locus was 4.The Polymorphism Information Content (PIC) value ranged from 0.37- 0.78 having an average of 0.58. The Un-weighted Pair Group Method with Arithmetic Mean (UPGMA) displayed three major clusters including some sub-clusters, where in Cluster 1, Binadhan- 8, Binadhan-10, Pokkali and FL478 were very close in their vicinity. Information obtained from this experiment, thus can be taken into account for stress breeding program and prospective genetic materials could be utilized for exploring the genetic architecture in favor of salt tolerance as well as for developing better salt tolerant rice varieties in near future.
SAARC J. Agri., 18(2): 1-15 (2020)
Germination and Seed Vigour of Indigenous Bean (Phaseolus Vulgaris) Genotype in Nepal
Authors: Uprety Anupam , Dahal Bhishma Raj , Shrestha Bishal 
Published: March 2021

Bean is an important vegetable crop of Nepal but farmers of Jumla district of Nepal are experiencing low productivity, probably due to poor germination. Keeping these points in view, a study was conducted to determine the germination and seed vigour of various indigenous beans genotype of Jumla district during February to March, 2018. The promising lines of Jumli beans namely KBL-3, KBL-2, PB0002, PB0001, KBL-1 and farm saved KBL-3 were used under study. The experiment was laid in completely randomized design (CRD) with four replications and six treatments namely T1 = KBL-3, T2 = KBL-2, T3 = PB0002, T4 = PB0001, T5 = KBL-1 and T6 = Farm-saved KBL-3. Significant differences were observed in germination percentage, speed of germination, seed vigourindex and true leaf emergence among different lines of Jumli beans .The highest germination percentage (96%), seed vigour index (1367) and speed of germination (1.763) was found in the variety of KBL-3 whereas the lowest germination percentage (69%), seed vigour index (947) and speed of germination (0.968) were found in the variety of KBL-1. Days to true leaf emergence was found shortest in the KBL-3 (23.50) and longest in the farm saved KBL-3 (30.25). KBL-3 pureline of Jumli bean was found to be highly responsive to seed germination and vigour characteristics. Thus, it would be better to suggest the indigenous bean growing farmers of Jumla district to cultivate KBL-3 for better germination and seed vigour.
SAARC J. Agri., 18(2): 67-75 (2020)
Polymorphism of Sakini Chicken Population From Different Locations/Altitudes of Nepal Using Randomly Amplified Polymorphic Dna Markers
Authors: Gorkhali NA , Dhakal R , Sapkota S , Koirala P , Pokhrel BR , Kolachhapati MR , Bhattarai N 
Published: March 2021

A study was conducted to evaluate genetic polymorphism in three Sakini chicken populations using random amplification of polymorphic DNA (RAPD) with seven highly polymorphic primers. All populations showed polymorphism with these primers that generates 59 different bands with an average of 8.4 bands per primer with 78.6% polymorphism nature. Primer OPA-16 produced the highest number of polymorphism bands 47 % and the lowest number of bands was produced by the OPA-05 primer 24 %. Differences for genetic distance (D) among populations were significant (P<0.05). A consensus dendogram was therefore developed to show the phylogenetic relationship among the populations. The cluster pattern is well supported by the principle component analysis that also separates all three populations of Sakini chicken into six major groups. The results provide evidence of the applicability of RAPD to determining genetic relatedness within and among different poultry populations and in developing reproducible markers useful in evaluating individual variation in poultry.
SAARC J. Agri., 18(2): 115-124 (2020)
Impact of Hydrometeorological Hazards on Agricultural Production at Chalan Beel, Bangladesh
Authors: Ahmed A , Hossain MS , Majumder AK 
Published: March 2021

Agriculture of Bangladesh is closely dependent on weather, rainfall pattern and land formation. However, frequent hydro-meteorological hazards cause to adversely affect the normal agricultural process and production. This study aimed to assess the impact of Hydro meteorological hazards on the crop cultivation practices, possible mitigation and adaptation measures for the farmers at Chalan Beel area under Pabna district, Bangladesh. There are 90 people having land and engaged with crop cultivation directly at Chalan Beel were been selected by applying purposive sampling method and interviewed by a pre-designed semi-structured questionnaire through face to face interview. The results revealed that Rice (93.75 %) and Garlic (47.5 %) are the major cultivating crops at Chalan Beel and 96 % of the farmers were been experienced with hydrometeorological devastation. The farmers perceived Nor’wester (77.9 %) as the most frequent hazard causing crop damage following by Heavy Rainfall (71.4 %), Hailstorm (68.8 %), Heavy Wind (45.5 %), Flashflood (42.9 %), Heavy Fog and Floods (19.5 % and 11.7 %) respectively. It is also identified that Nor’wester (58.4 %) and Heavy Rainfall (58.4 %) had maximum damage whereas Hailstorm (55.8 %), Heavy Wind and Flashflood also considerable adverse effects on overall crop production at this area. Only 24 % of farmers were found to change their cultivation pattern as the adaptation measure. This study portrayed that hydro-meteorological hazards are adversely affecting the crop production at Chalan Beel area and resulting economic loss. Therefore, government should ensure the participation of farmers along with adopting their deliberative in developing a strategic plan for providing technical support for diversification and training to adapt in this hazard prone area.
SAARC J. Agri., 18(2): 181-193 (2020)
EKSPRESI p53 DAN E-CADHERIN SEBAGAI PREDIKTOR PROGNOSIS PADA KARSINOMA SEL SKUAMOSA RONGGA MULUT DI RSUP DR. KARIADI SEMARANG
Authors: Pangaribuan Clara 
Published: March 2021

p53 AND E-CADHERIN EXPRESSION AS PREDICTORS OF PROGNOSTIC IN ORAL SQUAMOUS CELL CARCINOMA AT KARIADI HOSPITAL SEMARANG
THE EFFECTIVENESS OF CORIANDER (Coriandrum sativum L.) EXTRACTS ON REDUCING THE BLOOD SUGAR LEVELS OF ALLOXAN INDUCED WISTAR MALE RATS (Rattus norvegicus L.)
Authors: Dersing Kalvin 
Published: March 2021

AbstractBackground : Diabetes mellitus is the most common metabolic syndrome in the whole world with an incidence of 1-8%. This disease arises when insufficient insulin is produced or insulin cannot function properly.The ability of coriander juice water extract is expected to reduce blood glucose levels because the action is similar to insulin and can stimulate insulin release. Purpose : Knowing effectiveness coriander extract (Coriandrum sativum L.)to decline blood sugar levels in male white rats (Rattus norvegicus L.) wistar strain induced by alloxan. Method : This is a pure experimental study (true-experiment) using a pre and post test design with control group design using subjects namely white rats (Rattus norvegicus L.) male Wistar strain aged 10-12 weeks with a weight of 150-200 grams. By looking at changes in blood sugar levels during administration of alloxan and administration of coriander extract. Results : There were significant changes in some groups induced alloxan (p <0.05), but the effect of coriander extract was not very significant (p> 0.05). Conclusion : Coriander extract can control blood sugar levels to be stable or normal, but it takes longer and more research. Keywords : coriander extract, blood sugar levels, alloxan
The future of Funds for Innovative Medicines: results from a Delphi Study
Authors: Jommi Claudio , Armeni Patrizio , Bertolani Arianna , Costa Francesco , Otto Monica 
Published: March 2021

Introduction: Dedicated Funds for Innovative Medicines were introduced in 2017 for cancer and non-cancer drugs in Italy. After three years, their impact on patient access to the relevant treatments and critical issues about their management has been poorly investigated.
Aims and scope. This paper aims at bridging the literature gap and providing possible reforms scenarios.
Methods: Our analysis relied on a qualitative approach. The personal opinions of twelve Italian experts coming from the Ministry of Economy and Finance, the Scientific Committee of the Italian Medicines Agency, the Regions and Patient Associations, the Oncologists’ Scientific Societies and Hospital Pharmacists were elicited through a Delphi approach. A consensus on final recommendations was reached in two rounds.
Results: Experts were in favour of maintaining dedicated Funds for Innovative Medicines and had a distinct preference for a single Fund. Most of them suggested to extend access to Funds to more than three years, if, for the relevant indication, there are no alternatives to the innovative drug and provided that this does not represent a barrier to new entries. Responders advocated for Funds being covered by on top resources and the production of more evidence on their impact. They finally claimed a speeder flow of information to the regions on expenditure for innovative treatments and an enhancement of controls on prescribing behaviour, to avoid prescriptions be dependent on Funds capacity.
Conclusions: The consensus document provides for eight recommendations that could be taken into account for possible reforms and future research on this topic.