bluuebunny/crossref_metadata_2025_split huggingface dataset:
Water, walls, and bicycles: wealth index composition using census microdata
Authors: Lovaton Davila Rodrigo , McCarthy Aine Seitz , Gondwe Dorothy , Kirdruang Phatta , Sharma Uttam 
Published: March 2021

AbstractIn this study, we produce a valid and consistent variable for socioeconomic status (SES) at the household level with census microdata from ten developing countries available from the Integrated Public Use Microdata Series—International (IPUMS-I), the world's largest census database. We use principal components analysis to compute a wealth index based on asset ownership, utilities, and dwelling characteristics. We validate the index by verifying socioeconomic gradients on school enrollment and educational attainment. Given that the availability of socioeconomic indicators varies considerably across samples of census microdata, we implement a stepwise elimination procedure on the wealth index to identify the conditions that produce an internally consistent index. Using the results of the stepwise methodology, we propose which indicators are most important in measuring household SES. The development of the asset index for such a large archive of international census microdata is a very useful public resource for researchers.
Weather variability and transmissibility of COVID-19: a time series analysis based on effective reproductive number
Authors: Si Xiaohan , Bambrick Hilary , Zhang Yuzhou , Cheng Jian , McClymont Hannah , Bonsall Michael B. , Hu Wenbiao 
Published: March 2021

AbstractCOVID-19 is causing a significant burden on medical and healthcare resources globally due to high numbers of hospitalisations and deaths recorded as the pandemic continues. This research aims to assess the effects of climate factors (i.e., daily average temperature and average relative humidity) on effective reproductive number of COVID-19 outbreak in Wuhan, China during the early stage of the outbreak. Our research showed that effective reproductive number of COVID-19 will increase by 7.6% (95% Confidence Interval: 5.4% ~ 9.8%) per 1°C drop in mean temperature at prior moving average of 0–8 days lag in Wuhan, China. Our results indicate temperature was negatively associated with COVID-19 transmissibility during early stages of the outbreak in Wuhan, suggesting temperature is likely to effect COVID-19 transmission. These results suggest increased precautions should be taken in the colder seasons to reduce COVID-19 transmission in the future, based on past success in controlling the pandemic in Wuhan, China.
Reluctant and Illegal Migrants in Mao's China: Civil Defense Evacuation in the Tianjin Region, 1969–1980
Authors: Brown Jeremy 
Published: March 2021

AbstractMore than 100,000 people from the city of Tianjin were evacuated to the countryside in a civil defense program during the 1970s. Many evacuees refused to submit to state migration mandates, instead sneaking back to the city illegally or petitioning to regain urban residency. City officials responded flexibly to the evacuees’ pleas, sympathizing with family reunification and treating suburban districts (jiaoqu) on the outskirts of Tianjin as a buffer zone between city and countryside. Dominated by agriculture but home to a growing number of factories, workshops, and offices during the 1970s, jiaoqu became a solution to evacuation headaches. When compared with the recent coerced movement of hundreds of thousands of Chinese citizens on national security grounds, the civil defense evacuations of the 1970s suggest that it may be misguided to think of the Mao Zedong years as a faraway time that was more radical or repressive than China today.
Depression and worry symptoms predict future executive functioning impairment via inflammation
Authors: Zainal Nur Hani , Newman Michelle G. 
Published: March 2021

AbstractBackgroundScar models posit that heightened anxiety and depression can increase the risk for subsequent reduced executive function (EF) through increased inflammation across months. However, the majority of past research on this subject used cross-sectional designs. We therefore examined if elevated generalized anxiety disorder (GAD), major depressive disorder (MDD), and panic disorder (PD) symptoms forecasted lower EF after 20 months through heightened inflammation.MethodsCommunity-dwelling adults partook in this study (n = 614; MAGE = 51.80 years, 50% females). Time 1 (T1) symptom severity (Composite International Diagnostic Interview – Short Form), T2 (2 months after T1) inflammation serum levels (C-reactive protein, fibrinogen, interleukin-6), and T3 (20 months after T1) EF (Brief Test of Adult Cognition by Telephone) were assessed. Structural equation mediation modeling was performed.ResultsGreater T1 MDD and GAD (but not PD) severity predicted increased T2 inflammation (Cohen's d = 0.21–1.92). Moreover, heightened T2 inflammation forecasted lower T3 EF (d = −1.98 to −1.87). T2 inflammation explained 25–32% of the negative relations between T1 MDD or GAD and T3 EF. T1 GAD severity predicting T3 EF via T2 inflammation path was stronger among younger (v. older) adults. Direct effects of T1 MDD, GAD, and PD forecasting decreased T3 EF were found (d = −2.02 to −1.92). Results remained when controlling for socio-demographic, physical health, and lifestyle factors.ConclusionsInflammation can function as a mechanism of the T1 MDD or GAD–T3 EF associations. Interventions that successfully treat depression, anxiety, and inflammation-linked disorders may avert EF decrements.
Effects of the aqueous extract of Dicliptera verticillata on fertility and different stages of gestation in female rats
Authors: Meguem Stéphanie Ouabo , Lienou Landry Lienou , Goka Marie Stéphanie Chekem , Tagne Richard Simo , Yemele Didiane Mefokou , Telefo Phélix Bruno 
Published: March 2021

SummaryDicliptera verticillata is a medicinal plant traditionally used in western Cameroon to cure female infertility. This experiment was designed to assess the effects of the aqueous extract of Dicliptera verticillata (AEDv) on fertility and gestation in female rats. Oral increasing doses of AEDv were administered to immature female rats over 20 d. After this time, some animals were mated with fertile males and some fertility parameters were assayed; the other animals were euthanized for preliminary toxicity parameters analysis. The effects of AEDv on the different stages of gestation were assayed on selected animals previously controlled for estrous cycle regularity and mated. AEDv led to an increase in serum, uterine and ovarian proteins as well as in ovarian and uterine weights (P < 0.05) in immature female rats. Hepatic proteins significantly decreased (P < 0.01) in high dose-treated animals (50 and 100 mg/kg) compared with controls. The number of implantation sites and the fertility rate were significantly lower (P < 0.05), while the antifertility activity increased significantly (P < 0.05) in treated rats compared with controls. When administered from the 1st to the 5th day of pregnancy, AEDv led to a decrease of more than 60% in the implantation rate in high dose-treated rats (50, 100, and 400 mg/kg). From the 6th to the 9th day, the implantation, gestation rates and the number of fetuses decreased significantly in all treated groups. From the 11th to the 20th day, a 50% resorption and decrease in gestation rate were reported in 50 mg/kg dose-treated animals. AEDv possesses weak contraceptive and abortifacient effects during pregnancy.
Acid and aluminium-tolerant microbes isolated from China space station assembly cleanroom surfaces and identified by 16S rRNA/ITS sequencing and MALDI-TOF MS
Authors: Rcheulishvili Nino , Papukashvili Dimitri , Shakir Yasmeen , Deng Yulin , Zhang Ying 
Published: March 2021

AbstractCorrosion of aluminium (Al) is a potential problem for spacecraft as this metal is used for various mechanical parts due to its strength, durability, etc. However, it can be corroded by certain factors including microbes. Studying microbes which can be implicated in microbiologically influenced corrosion (MIC) due to their extremophilic nature is of vital importance. In this current study, Al and acid-tolerant microbes were isolated from the samples of China space station assembly cleanroom surfaces; acidic environments can accelerate the corrosion process on metal surfaces. Nine bacterial and 10 fungal strains were identified with 16S ribosomal RNA gene/internal transcribed spacer region sequencing and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The dominant bacteria were of Bacillus, fungi of Penicillium and Aspergillus genera. Knowing the microbes which may be conveyed from the cleanrooms to the space stations with a potential capacity of Al degradation is important for long-term maintenance of station components. This study might aid in designing further researches of the aforementioned microorganisms and, therefore, contribute to the prevention of MIC.
Control of Palmer amaranth (Amaranthus palmeri) regrowth following failed applications of glufosinate and fomesafen
Authors: Haarmann Jesse A. , Young Bryan G. , Johnson William G. 
Published: March 2021

AbstractRapid vegetative growth and adverse application conditions are common factors leading to the failure of postemergence herbicides on Palmer amaranth. A sequential herbicide application, or respray, is often necessary to control weeds that have survived the initial herbicide application to protect crop yield and minimize weed seed production. The optimum timing after the initial application and the most effective herbicide for control of Palmer amaranth has not been characterized. The objectives of these experiments were to determine the optimum herbicide for treating Palmer amaranth regrowth, the optimum timing for each of those herbicides, and how the initial failed herbicide might affect efficacy of a second herbicide application. Bare ground field experiments were performed in 2017 and 2018 in which glufosinate or fomesafen herbicide failure was induced on Palmer amaranth plants that were 30 cm in height. Respray treatments of glufosinate, fomesafen, lactofen, 2,4-D, and dicamba were applied once at timings of 4 to 5 d, 7 d, or 11 d after the initial spray application. Nearly all herbicide treatment and timing combinations increased control by at least 13 percentage points compared to no respray herbicide treatment. Regardless of initial herbicide, glufosinate applied as a respray treatment was the most consistent and efficacious with up to 97% control. The specific herbicide used in the second application impacted final weed control more so than timing of the respray application. For instance, control by glufosinate respray treatments was 10 to 18 percentage points greater than control from lactofen respray treatments, whereas control decreased by 3 percentage points when respray applications of any herbicide were made 11 d after initial application of glufosinate compared to 4 to 5 and 7 d after initial application of glufosinate. In the event of failure to control Palmer amaranth with glufosinate or fomesafen, glufosinate should be applied in order to maximize control.
Observational Evidence for Whistler Mode Waves Guided/Ducted by the Inner and Outer Edges of the Plasmapause
Authors: Chen Rui , Gao Xinliang , Lu Quanming , Tsurutani Bruce T. , Wang Shui 
Published: March 2021

AbstractWe present observational support for whistler mode waves guidance by the plasmapause gradients based on a case study and statistical analyses. Due to the combined effects of inhomogeneous magnetic fields and plasma densities, whistler mode waves near the inner edge of plasmapause (plasmasphere side) will be guided by a high density duct‐like (HDD) gradient, and tend to have very small wave normal angles (WNAs ≤ 20°) relative to the ambient magnetic field,B0. In contrast, whistler mode waves near the outer edge of the plasmapause (plasmatrough side) guided by a low density duct‐like (LDD) gradient, tend to have quite large WNAs (≥∼60°). Statistical analyses emphasize these remarkably different properties of waves in the plasmapause gradients. The results indicate that the wave ducting effects at the plasmapause may lead to unusual and anomalous energetic pitch angle scattering.
Nanoprinted high-neuron-density optical linear perceptrons performing near-infrared inference on a CMOS chip
Authors: Goi Elena , Chen Xi , Zhang Qiming , Cumming Benjamin P. , Schoenhardt Steffen , Luan Haitao , Gu Min 
Published: March 2021

AbstractOptical machine learning has emerged as an important research area that, by leveraging the advantages inherent to optical signals, such as parallelism and high speed, paves the way for a future where optical hardware can process data at the speed of light. In this work, we present such optical devices for data processing in the form of single-layer nanoscale holographic perceptrons trained to perform optical inference tasks. We experimentally show the functionality of these passive optical devices in the example of decryptors trained to perform optical inference of single or whole classes of keys through symmetric and asymmetric decryption. The decryptors, designed for operation in the near-infrared region, are nanoprinted on complementary metal-oxide–semiconductor chips by galvo-dithered two-photon nanolithography with axial nanostepping of 10 nm1,2, achieving a neuron density of >500 million neurons per square centimetre. This power-efficient commixture of machine learning and on-chip integration may have a transformative impact on optical decryption3, sensing4, medical diagnostics5 and computing6,7.
Randomized trial of azithromycin to eradicate Ureaplasma respiratory colonization in preterm infants: 2-year outcomes
Authors: Viscardi Rose M. , Terrin Michael L. , Magder Laurence S. , Davis Natalie L. , Dulkerian Susan J. , Waites Ken B. , Allen Marilee , Ajayi-Akintade Ajoke , Ambalavanan Namasivayam , Kaufman David A. , Donohue Pamela , Tuttle Deborah J. , Weitkamp Jörn-Hendrik 
Published: March 2021

Abstract
Background
To assess the potential impact of azithromycin treatment in the first week following birth on 2-year outcomes in preterm infants with and without Ureaplasma respiratory colonization who participated in a double-blind, placebo-controlled randomized controlled trial.

Methods
Respiratory morbidity was assessed at NICU discharge and at 6, 12, and 22–26 months corrected age using pulmonary questionnaires. Comprehensive neurodevelopmental assessments were completed between 22 and 26 months corrected age. The primary and secondary composite outcomes were death or severe respiratory morbidity and death or moderate–severe neurodevelopmental impairment, respectively, at 22–26 months corrected age.

Results
One hundred and twenty-one randomized participants (azithromycin, N = 60; placebo, N = 61) were included in the intent-to-treat analysis. There were no significant differences in death or serious respiratory morbidity (34.8 vs 30.4%, p = 0.67) or death or moderate–severe neurodevelopmental impairment (47 vs 33%, p = 0.11) between the azithromycin and placebo groups. Among all trial participants, tracheal aspirate Ureaplasma-positive infants experienced a higher frequency of death or serious respiratory morbidity at 22–26 months corrected age (58%) than tracheal aspirate Ureaplasma-negative infants (34%) or non-intubated infants (21%) (p = 0.028).

Conclusions
We did not observe strong evidence of a difference in long-term pulmonary and neurodevelopment outcomes in preterm infants treated with azithromycin in the first week of life compared to placebo.

Impact

No strong evidence of a difference in long-term pulmonary and neurodevelopment outcomes was identified at 22–26 months corrected age in infants treated with azithromycin in the first week of life compared to placebo.

The RCT is the first study of 2-year pulmonary and neurodevelopmental outcomes of azithromycin treatment in ELGANs.

Provides evidence that ELGANs with lower respiratory tract Ureaplasma have the most frequent serious respiratory morbidity in the first 2 years of life, suggesting that a Phase III trial of azithromycin to prevent BPD targeting this population is warranted.
Locally adapted gut microbiomes mediate host stress tolerance
Authors: Houwenhuyse Shira , Stoks Robby , Mukherjee Shinjini , Decaestecker Ellen 
Published: March 2021

Abstract
While evidence for the role of the microbiome in shaping host stress tolerance is becoming well-established, to what extent this depends on the interaction between the host and its local microbiome is less clear. Therefore, we investigated whether locally adapted gut microbiomes affect host stress tolerance. In the water flea Daphnia magna, we studied if the host performs better when receiving a microbiome from their source region than from another region when facing a stressful condition, more in particular exposure to the toxic cyanobacteria Microcystis aeruginosa. Therefore, a reciprocal transplant experiment was performed in which recipient, germ-free D. magna, isolated from different ponds, received a donor microbiome from sympatric or allopatric D. magna that were pre-exposed to toxic cyanobacteria or not. We tested for effects on host life history traits and gut microbiome composition. Our data indicate that Daphnia interact with particular microbial strains mediating local adaptation in host stress tolerance. Most recipient D. magna individuals performed better when inoculated with sympatric than with allopatric microbiomes. This effect was most pronounced when the donors were pre-exposed to the toxic cyanobacteria, but this effect was also pond and genotype dependent. We discuss how this host fitness benefit is associated with microbiome diversity patterns.
Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours
Authors: Gampala Silpa , Shah Fenil , Zhang Chi , Rhodes Steven D. , Babb Olivia , Grimard Michelle , Wireman Randall S. , Rad Ellie , Calver Brian , Bai Ren-Yuan , Staedtke Verena , Hulsey Emily L. , Saadatzadeh M. Reza , Pollok Karen E. , Tong Yan , Smith Abbi E. , Clapp D. Wade , Tee Andrew R. , Kelley Mark R. , Fishel Melissa L. 
Published: March 2021

Abstract
Background
MPNST is a rare soft-tissue sarcoma that can arise from patients with NF1. Existing chemotherapeutic and targeted agents have been unsuccessful in MPNST treatment, and recent findings implicate STAT3 and HIF1-α in driving MPNST. The DNA-binding and transcriptional activity of both STAT3 and HIF1-α is regulated by Redox factor-1 (Ref-1) redox function. A first-generation Ref-1 inhibitor, APX3330, is being tested in cancer clinical trials and could be applied to MPNST.

Methods
We characterised Ref-1 and p-STAT3 expression in various MPNST models. Tumour growth, as well as biomarkers of apoptosis and signalling pathways, were measured by qPCR and western blot following treatment with inhibitors of Ref-1 or STAT3.

Results
MPNSTs from Nf1-Arfflox/floxPostnCre mice exhibit significantly increased positivity of p-STAT3 and Ref-1 expression when malignant transformation occurs. Inhibition of Ref-1 or STAT3 impairs MPNST growth in vitro and in vivo and induces apoptosis. Genes highly expressed in MPNST patients are downregulated following inhibition of Ref-1 or STAT3. Several biomarkers downstream of Ref-1 or STAT3 were also downregulated following Ref-1 or STAT3 inhibition.

Conclusions
Our findings implicate a unique therapeutic approach to target important MPNST signalling nodes in sarcomas using new first-in-class small molecules for potential translation to the clinic.
Self-consistent solution for the magnetic exchange interaction mediated by a superconductor
Authors: Ghanbari Atousa , Risinggård Vetle K. , Linder Jacob 
Published: March 2021

AbstractWe theoretically determine the magnetic exchange interaction between two ferromagnets coupled by a superconductor using a tight-binding lattice model. The main purpose of this study is to determine how the self-consistently determined superconducting state influences the exchange interaction and the preferred ground-state of the system, including the role of impurity scattering. We find that the superconducting state eliminates RKKY-like oscillations for a sufficiently large superconducting gap, making the anti-parallel orientation the ground state of the system. Interestingly, the superconducting gap is larger in the parallel configuration than in the anti-parallel configuration, giving a larger superconducting condensation energy, even when the preferred ground state is anti-parallel. We also show that increasing the impurity concentration in the superconductor causes the exchange interaction to decrease, likely due to an increasing localization of the mediating quasiparticles in the superconductor.
Nesting of Ceratina nigrolabiata, a biparental bee
Authors: Mikát Michael , Matoušková Eva , Straka Jakub 
Published: March 2021

AbstractBiparental care is very rare in insects, and it was well-documented in only one bee species to this date – Ceratina nigrolabiata. However, biparental care was only recently discovered in this species, and detailed description of natural history of this species is missing. Here, we describe the nesting cycle ofC. nigrolabiata. Pairs ofC. nigrolabiataare established before female starts offspring provisioning. After provisioning is finished (when youngest offspring reached larval stage), the male abandons the nest. Males which are present in nests where female already finished provisioning brood cells, are probably mainly temporary visitors. The female can perform long-time offspring guarding, but only 22% of completely provisioned nests are guarded by a female. Most nests (54%) are closed and abandoned, when provisioning is completed, and other (24%) are orphaned before provisioning is finished. Guarded nests have statistically higher number of brood cells provisioned than unguarded nests. Generally,C. nigrolabiatais unique among bees due to its biparental behavior, but it has also uncommon traits of nesting biology amongCeratinabees, e.g. fast offspring development in comparison with provisioning rate, and high proportion of nests which are closed and abandoned by mother.
Comparison of the effect of air tamponade versus no tamponade after pars plana vitrectomy for idiopathic epiretinal membrane
Authors: Jang Kyuhwan , Hwang Daniel Duck-Jin , Ahn Jayoung , Son Gisung , Park Ji In , Sohn Joonhong 
Published: March 2021

AbstractThis study aimed to compare the surgical outcomes of pars plana vitrectomy (PPV) with and without air tamponade in patients with idiopathic epiretinal membrane (iERM). We prospectively enrolled 145 patients with iERM who underwent a 25-gauge transconjunctival sutureless PPV. Patients were assigned to either the air tamponade (air) group (79 eyes) or balanced salt solution (BSS; no tamponade) group (66 eyes). The central macular thickness (CMT), peripapillary retinal nerve fiber layer (pRNFL) thickness, and best-corrected visual acuity (BCVA) were compared for two years. At baseline, there were no significant differences between the two groups. CMT and BCVA were not significantly different between the groups for 2 years. However, the air group had a significantly lower thickness in the superior temporal pRNFL sector at 1 month (p = 0.01) and in the inferior temporal and superior temporal pRNFL sectors at 3 months (p = 0.02 for both). There were no significant differences between both groups in all the pRNFL sectors from 6 months to 2 years. The outcomes of PPV with air tamponade and that with no tamponade appear to be equivalent. This shows that air tamponade may not be an imperative procedure for iERM surgery and has no additional benefit.