bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid resolution of severe exudation in uveal effusion syndrome with anti-vascular endothelial growth factor alone in a case of bilateral nanophthalmos: a case report
Authors: Song Li , Dong Fangtian , Yi Changxian 
Published: October 2021

Abstract
Background
Uveal effusion syndrome is a rare disease characterized by exudative detachments of the choroid, ciliary body, and retina. Various surgical procedures and nonsurgical strategies have been described to treat uveal effusion syndrome with limited success. The treatment for uveal effusion syndrome remains a serious challenge for clinicians. To the best of our knowledge, no previous report has described a severe uveal effusion syndrome patient with nanophthalmos treated by using an anti-vascular endothelial growth factor agent alone. We report here one such case with unexpected positive results.

Case presentation
A 30-year-old Chinese male patient presented with painless vision loss in both eyes that had persisted for 2 months. Examination of the right eye revealed a best corrected visual acuity of 0.03; the best corrected visual acuity of the left eye was finger count/20 cm. The intraocular pressure was normal on both eyes. A-scan revealed an right eye axial length of 15.88 mm and a left eye axial length of 16.21 mm. In the right eye, half of the peripheral choroid and nearly three-fourths of the retina were detached. The left fundus was not visible because of the total retinal detachment located just behind the lens, which could be clearly observed directly with a slit lamp. Considering all the possibilities and available treatments as well as the patient’s intentions after discussion, we first administered an intravitreal injection of ranibizumab 0.5 ml into both eyes. The patient’s visual perception improved 3 days after the injection. One month later, most of the effusion under the choroid and retina was absorbed. Visual acuity improved from finger count to 0.05 in both eyes, and vision quality was remarkably improved. Encouraged by this good result, the patient opted to undergo a second injection 1 month later. Choroidal and retinal detachment completely vanished 30 days after the second injection.

Conclusions
Using an anti-vascular endothelial growth factor agent alone may be a potentially effective and safe method for managing some types of uveal effusion syndrome, such as in nanophthalmos. The injection may be administered before considering more aggressive procedures in some uveal effusion syndrome patients.
Neuropsychological and psychological dysfunctions associated with coronavirus disease 2019: a case report
Authors: Damianova Maria 
Published: October 2021

Abstract
Background
Patient’s account of personal experiences of having lived through coronavirus disease 2019 is important for understanding the magnitude of the debilitating impact of the infection. There is increasing recognition that the infection impedes multiple functional domains, but to date the evidence remains scarce. Moreover, to the author’s knowledge, there are no documented cases reporting on research data derived from self-reflective first-person experience.

Case presentation
The patient was a 59-year-old female psychologist of White self-ascribed ethnicity who had coronavirus disease 2019. She had no history of medical, neurological, or psychiatric conditions and works in a neurosurgery clinic at a large hospital as a psychologist, specializing in neuropsychology. Using the introspective method, she captured the occurrence of neuropsychological and psychological dysfunctions she experienced in the acute stage of the illness, which took place in December 2020 and lasted for 17 days. Treatment of coronavirus disease 2019 was conducted in the home environment under medical supervision and followed a standardized protocol adopted at the time in the country.

Conclusions
The data derived from the first-person experience indicated that among the most salient cognitive functions impacted by the disease were: executive control, working memory, attention, concentration, and processing speed.
Furthermore, emotional instability; mood swings; racing, repetitive, or intrusive thoughts; uncontrolled associations; dizziness; fatigue; disbalance; and sleep disturbances featured consistently throughout the illness. The overall profile of these dysfunctions suggests disruption in the overall operation of the brain and particularly in the functioning of the frontal lobes. Although less tangible than the physical symptoms, the neuropsychological and psychological dysfunctions associated with coronavirus disease 2019 form a distinct cluster that has a highly debilitating impact on a person’s well-being.
Transesophageal echocardiography for cardiovascular risk estimation in patients with sepsis and new-onset atrial fibrillation: a multicenter prospective pilot study
Authors: Labbé Vincent , Ederhy Stephane , Lapidus Nathanael , Joffre Jérémie , Razazi Keyvan , Laine Laurent , Sy Oumar , Voicu Sebastian , Chemouni Frank , Aissaoui Nadia , Smonig Roland , Doyen Denis , Carrat Fabrice , Voiriot Guillaume , Mekontso-Dessap Armand , Cohen Ariel , Fartoukh Muriel ,   for the FAST Study Group, Guidet Bertrand , Ait-Oufella Hafid , Bourcier Simon , Da Silva Daniel , Jochmans Sebastien , Dellamonica Jean , Timsit Jean-François , Megarbane Bruno , Diehl Jean-Luc , Rushton-Smith Sophie 
Published: October 2021

Abstract
Background
Echocardiographic parameters have been poorly investigated for estimating cardiovascular risk in patients with sepsis and new-onset atrial fibrillation. We aim to assess the prevalence of transesophageal echocardiographic abnormalities and their relationship with cardiovascular events in mechanically ventilated patients with sepsis and new-onset atrial fibrillation.

Methods
In this prospective multicenter pilot study, left atrial/left atrial appendage (LA/LAA) dysfunction, severe aortic atheroma, and left ventricular systolic dysfunction were assessed using an initial transesophageal echocardiographic study, which was repeated after 48–72 h to detect LA/LAA thrombus formation. The study outcome was a composite of cardiovascular events at day 28, including arterial thromboembolic events (ischemic stroke, non-cerebrovascular arterial thromboembolism, LA/LAA thrombus), major bleeding, and all-cause death.

Results
The study population comprised 94 patients (septic shock 63%; 35% women; median age 69 years). LA/LAA dysfunction, severe aortic atheroma, and left ventricular systolic dysfunction were detected in 17 (19%), 22 (24%), and 27 (29%) patients, respectively. At day 28, the incidence of cardiovascular events was 46% (95% confidence interval [CI]: 35 to 56). Arterial thromboembolic events and major bleeding occurred in 7 (7%) patients (5 ischemic strokes, 1 non-cerebrovascular arterial thromboembolism, 2 left atrial appendage thrombi) and 18 (19%) patients, respectively. At day 28, 27 patients (29%) died. Septic shock (hazard ratio [HR]: 2.36; 95% CI 1.06 to 5.29) and left ventricular systolic dysfunction (HR: 2.06; 95% CI 1.05 to 4.05) were independently associated with cardiovascular events.

Conclusions
Transesophageal echocardiographic abnormalities are common in mechanically ventilated patients with sepsis and new-onset atrial fibrillation, but only left ventricular systolic dysfunction was associated with cardiovascular events at day 28.
Warmblood fragile foal syndrome causative single nucleotide polymorphism frequency in horses in Ireland
Authors: Rowe Áine , Flanagan Sharon , Barry Gerald , Katz Lisa M. , Lane Elizabeth A. , Duggan Vivienne 
Published: October 2021

Abstract
Background
Warmblood Fragile Foal Syndrome (WFFS) is an autosomal recessive disorder caused by a mutation in the procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 (PLOD1) gene. Homozygosity for the mutation results in defective collagen synthesis which clinically manifests as the birth of non viable or still born foals with abnormally fragile skin. While the mutation has been identified in non Warmblood breeds including the Thoroughbred, to date all homozygous clinically affected cases reported in the scientific literature are Warmblood foals. The objective of this study was to investigate the carrier frequency of the mutation in the Thoroughbred and sport horse populations in Ireland.

Methods
A test was developed at the UCD School of Veterinary Medicine using real-time PCR to amplify the PLOD1 gene c.2032G > A variant. A subset of the samples was also submitted to an external laboratory with a licensed commercial WFFS genetic test.

Results
Warmblood Fragile Foal Syndrome genotyping was performed on hair samples from 469 horses representing 6 different breeds. Six of 303 (1.98%) sport horses tested and three of 109 (2.75%) Thoroughbreds tested were heterozygous for the WFFS polymorphism (N/WFFS). The WFFS polymorphism was not identified in the Standardbred, Cob, Connemara, or other pony breeds.

Conclusions
The study identified a low frequency of the WFFS causative mutation in sport horses and Thoroughbreds in Ireland, highlighting the importance of WFFS genetic testing in order to identify phenotypically normal heterozygous carriers and to prevent the birth of nonviable foals.
Existence and nonexistence of entire k-convex radial solutions to Hessian type system
Authors: Cui Jixian 
Published: October 2021

AbstractIn this paper, a Hessian type system is studied. After converting the existence of an entire solution to the existence of a fixed point of a continuous mapping, the existence of entirek-convex radial solutions is established by the monotone iterative method. Moreover, a nonexistence result is also obtained.
On a generalized fractional boundary value problem based on the thermostat model and its numerical solutions via Bernstein polynomials
Authors: Etemad Sina , Tellab Brahim , Deressa Chernet Tuge , Alzabut Jehad , Li Yongkun , Rezapour Shahram 
Published: October 2021

AbstractIn this paper, we introduce a new structure of the generalized multi-point thermostat control model motivated by its standard model. By presenting integral solution of this boundary problem, the existence property along with the uniqueness property are investigated by means of a special version of contractions named μ-φ-contractions and the Banach contraction principle. Then, on the given nonlinear generalized BVP of thermostat, the Bernstein polynomials are introduced and numerical solutions obtained by them are presented. At the end, three different structures of nonlinear thermostat models are designed and the results are examined.
Shape-adjustable developable generalized blended trigonometric Bézier surfaces and their applications
Authors: Maqsood Sidra , Abbas Muhammad , Miura Kenjiro T. , Majeed Abdul , Hu Gang , Nazir Tahir 
Published: October 2021

AbstractDevelopable surfaces have a vital part in geometric modeling, architectural design, and material manufacturing. Developable Bézier surfaces are the important tools in the construction of developable surfaces, but due to polynomial depiction and having no shape parameter, they cannot describe conics exactly and can only handle a few shapes. To tackle these issues, two straightforward techniques are proposed to the computer-aided design of developable generalized blended trigonometric Bézier surfaces (for short, developable GBT-Bézier surfaces) with shape parameters. A developable GBT-Bézier surface is established by making a collection of control planes with generalized blended trigonometric Bernstein-like (for short, GBTB) basis functions on duality principle among points and planes in 4D projective space. By changing the values of shape parameters, a group of developable GBT-Bézier surfaces that preserves the features of the developable GBT-Bézier surfaces can be generated. Furthermore, for a continuous connection among these developable GBT-Bézier surfaces, the necessary and sufficient $G^{1}$

G
1

and $G^{2}$

G
2

(Farin–Boehm and beta) continuity conditions are also defined. Some geometric designs of developable GBT-Bézier surfaces are illustrated to show that the suggested scheme can settle the shape and position adjustment problem of developable Bézier surfaces in a better way than other existing schemes. Hence, the suggested scheme has not only all geometric features of current curve design schemes but surpasses their imperfections which are usually faced in engineering.
Existence, uniqueness, and approximate solutions for the general nonlinear distributed-order fractional differential equations in a Banach space
Authors: Eftekhari Tahereh , Rashidinia Jalil , Maleknejad Khosrow 
Published: October 2021

AbstractThe purpose of this paper is to provide sufficient conditions for the local and global existence of solutions for the general nonlinear distributed-order fractional differential equations in the time domain. Also, we provide sufficient conditions for the uniqueness of the solutions. Furthermore, we use operational matrices for the fractional integral operator of the second kind Chebyshev wavelets and shifted fractional-order Jacobi polynomials via Gauss–Legendre quadrature formula and collocation methods to reduce the proposed equations into systems of nonlinear equations. Also, error bounds and convergence of the presented methods are investigated. In addition, the presented methods are implemented for two test problems and some famous distributed-order models, such as the model that describes the motion of the oscillator, the distributed-order fractional relaxation equation, and the Bagley–Torvik equation, to demonstrate the desired efficiency and accuracy of the proposed approaches. Comparisons between the methods proposed in this paper and the existing methods are given, which show that our numerical schemes exhibit better performances than the existing ones.
Evidence of the impacts of pharmaceuticals on aquatic animal behaviour: a systematic map protocol
Authors: Martin Jake M. , Bertram Michael G. , Blanchfield Paul J. , Brand Jack A. , Brodin Tomas , Brooks Bryan W. , Cerveny Daniel , Lagisz Malgorzata , Ligocki Isaac Y. , Michelangeli Marcus , Nakagawa Shinichi , Orford Jack T. , Sundin Josefin , Tan Hung , Wong Bob B. M. , McCallum Erin S. 
Published: October 2021

Abstract
Background
Globally, there is growing concern over the impacts of pharmaceuticals and drug manufacturing on aquatic animals, and pharmaceuticals are now recognized as contaminants of emerging environmental concern. In recent years, scientists, environmental managers, and policymakers have been interested in using behavioural endpoints for chemical regulation, given their importance for fitness and survival. The body of research on whether and how pharmaceutical exposure alters the behaviour of aquatic animals has grown exponentially, making it difficult to get an overview of the results. With an international spotlight on the management of these environmental threats, synthesizing the currently available data is vital to inform managers and policymakers, as well as highlighting areas where more research is needed. This is a protocol for a systematic evidence map (SEM) and serves as an a priori record of our objectives and methodological decisions. Our objectives are to identify, catalogue, and present primary research articles on the effects of human and veterinary pharmaceuticals on aquatic animal behaviour.

Methods
The literature search will be conducted using two electronic databases: Web of Science and Scopus, and we will supplement these searches with additional sources. The search string has been developed using a Population–Exposure–Comparison–Outcome (PECO) framework, to capture articles that used an aquatic organism (P, population) to test the effects of a pharmaceutical (E, exposure) on behaviour (O, outcome). Eligible articles must also have a control group (C, comparison). Articles will be screened in two stages, title and abstract, followed by full-text screening before data extraction. Decision trees have been designed a priori to appraise articles for eligibility at both stages of screening. At both stages, screening each article will be completed by two independent reviewers. Study validity will be appraised but not used as a basis for article inclusion. The information extracted from the eligible articles, along with bibliometric data, will be mapped and displayed. All data associated with this SEM will be publicly available through the Open Science Framework (OSF) and a future project webpage.
A systematic review of cognitive behavior therapy and dialectical behavior therapy for adolescent eating disorders
Authors: Vogel Emily N. , Singh Simar , Accurso Erin C. 
Published: October 2021

Abstract
Background
Eating disorders have serious psychological and physical consequences. Current evidence-based treatments for adolescents with eating disorders have modest effects, underscoring the need to improve current treatment approaches. Cognitive behavior therapy (CBT) and dialectical behavior therapy (DBT) have been proposed as alternative treatment options, with burgeoning research in this area. This review aims to summarize and critically analyze the current literature on the feasibility, acceptability, effectiveness, and efficacy of CBT and DBT for adolescent eating disorders, and then proposes areas of future research.

Methods
PsycINFO and PubMed were searched using the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines to identify studies examining the feasibility, acceptability, effectiveness and/or efficacy of CBT or DBT for adolescent eating disorders.

Results
Eligible studies (N = 50; CBT: n = 40, DBT: n = 10) indicated that both treatments are reasonably feasible, acceptable, and possibly effective for adolescent eating disorders across diagnoses and levels of care, though efficacy trials are lacking.

Conclusions
CBT and DBT demonstrate promise as alternatives to family-based approaches for adolescent eating disorders. Adequately powered trials to establish the effectiveness and efficacy of CBT and DBT are needed, particularly ones that compare these treatments against other leading approaches.

Plain English summary
Despite high rates of relapse and likelihood for severe and enduring illness, there is a dearth of evidence-based treatment options for adolescents with eating disorders. Potentially viable but less well-studied treatments for adolescents with eating disorders include cognitive behavior therapy (CBT) and dialectical behavior therapy (DBT). This systematic review of CBT and DBT for adolescent eating disorders focuses on feasibility (i.e., how easy it was to implement the treatment), acceptability (i.e., how well the intervention was received by patients and therapists), effectiveness (i.e., how well the intervention performed under routine, real-world circumstances), and efficacy (i.e., how well the intervention performed in highly-controlled research settings). This review concludes that research supports the feasibility and acceptability of these approaches, as well as preliminary evidence of their effectiveness. However, the field is lacking studies that systematically compare CBT and DBT to other evidence-based approaches. Recommendations to advance research on CBT and DBT for adolescent eating disorders are provided, including a call for efficacy studies that clarify their performance compared to other leading approaches.
The association between problematic social networking site use, dark triad traits, and emotion dysregulation
Authors: Hussain Zaheer , Wegmann Elisa , Griffiths Mark D. 
Published: October 2021

Abstract
Background
Social networking sites (SNSs) allow people to socially connect with each other, collaborate, and share information. However, problematic SNS use (PSNSU) may be associated with negative personality traits. The present study investigated the associations between PSNSU, dark triad personality traits, and emotion dysregulation.

Method
In the present study, 555 SNS users (Mage = 33.32 years, SD = 10.88) completed an online survey comprising measures of PSNSU, dark triad personality traits, and emotion dysregulation.

Results
Bivariate correlations showed that PSNSU was significantly associated with dark triad traits as well as emotion dysregulation. Structural equation modelling (where the effect of the dark triad traits on PSNSU was mediated by emotion dysregulation) showed that 33.5% of the variance of PSNSU was explained by Machiavellianism, psychopathy, and narcissism.

Conclusion
The findings provide suggestive evidence of why PSNSU may occur as a function of the presence of dark triad traits and emotion dysregulation. The study also highlighted the important role that emotion regulation plays in the association between dark triad traits and PSNSU.
Identification and structural analysis of a thermophilic β-1,3-glucanase from compost
Authors: Feng Jianwei , Xu Shenyuan , Feng Ruirui , Kovalevsky Andrey , Zhang Xia , Liu Dongyang , Wan Qun 
Published: October 2021

Abstractβ-1,3-glucanase can specifically hydrolyze glucans to oligosaccharides and has potential applications in biotechnology. We used the metatranscriptomic technology to discover a thermophilic β-1,3-glucanase from compost. The phylogenetic study shows that it belongs to the family 16 glycoside hydrolase (GH16) and is most homologous with an enzyme fromStreptomyces sioyaensis, an actinobacterium. It has the activity of 146.9 U/mg in the optimal reaction condition (75 °C and pH 5.5). Its catalytic domain was crystallized and diffracted to 1.14 Å resolution. The crystal structure shows a sandwich-like β-jelly-roll fold with two disulfide bonds. After analyzing the occurring frequencies of these cysteine residues, we designed two mutants (C160G and C180I) to study the role of these disulfide bonds. Both mutants have decreased their optimal temperature from 75 to 70 °C, which indicate that the disulfide bonds are important to maintain thermostability. Interestingly, the activity of C160G has increased ~ 17% to reach 171.4 U/mg. We speculate that the increased activity of C160G mutant is due to increased dynamics near the active site. Our studies give a good example of balancing the rigidity and flexibility for enzyme activity, which is helpful for protein engineering.