bluuebunny/crossref_metadata_2025_split huggingface dataset:
Música na formação acadêmico-profissional nos cursos de Pedagogia: 20 anos de pesquisa
Authors: Natera Gislene , Mateiro Teresa 
Published: May 2021

Este estudo analisa teses e dissertações produzidas nos últimos 20 anos com o objetivo de compreender as relações da música no contexto da formação acadêmico-profissional dos cursos de Licenciatura em Pedagogia. Foram mapeadas 33 pesquisas defendidas em programas brasileiros de pós-graduação, tendo sido agrupadas em dois blocos: formação continuada com 18 trabalhos e formação acadêmico-profissional com 15. Em ambos foram descritos e analisados temas, objetivos, referenciais teóricos, procedimentos metodológicos e resultados. O segundo grupo de pesquisas recebeu um tratamento de dados mais detalhado e os resultados demonstram que: as temáticas mais estudadas referem-se à estrutura dos cursos, identidades das estudantes, processos da docência e o lugar da música na Pedagogia; o estudo de caso foi a metodologia adotada por 40% dos pesquisadores; os emissores do discurso sobre pedagogia e educação musical são autores nacionais e estrangeiros; a legislação educacional é mencionada na maioria dos trabalhos; programas de Pós-Graduação em Educação produzem mais pesquisas na temática em questão do que os de música; a carga horária nos cursos não é suficiente para a aprendizagem de um conhecimento específico em música; as parcerias entre professoras de referências e professoras especialistas têm sido uma alternativa de atuação para as egressas; entre outros. Para dar continuidade às investigações, aponta-se, por um lado, a necessidade de estudos em todas as regiões e in loco e, por outro, a inclusão das músicas do cotidiano das crianças na formação das pedagogas.
Aggression, Escalation, and Other Latent Themes in Legal Intervention Deaths of Non-Hispanic Black and White Men: Results From the 2003‒2017 National Violent Death Reporting System
Authors: Arseniev-Koehler Alina , Foster Jacob Gates , Mays Vickie M. , Chang Kai-Wei , Cochran Susan D. 
Published: May 2021

Objectives. To investigate racial/ethnic differences in legal intervention‒related deaths using state-of-the-art topic modeling of law enforcement and coroner text summaries drawn from the 2003–2017 US National Violent Death Reporting System (NVDRS). Methods. Employing advanced topic modeling, we identified 8 topics consistent with dangerousness in death incidents in the NVDRS death narratives written by public health workers (PHWs). Using logistic regression, we then evaluated racial/ethnic differences in PHW-coded variables and narrative topics among 4981 males killed by legal intervention, while adjusting for age, county-level characteristics, and year. Results. Black, as compared with White, decedents were younger and their deaths were less likely to include PHW-coded mental health or substance use histories, weapon use, or positive toxicology for alcohol or psychoactive drugs, but more likely to include “gangs-as-an-incident-precipitant” coding. Topic modeling revealed less frequent thematic representation of “physical aggression” or “escalation” but more of “gangs or criminal networks” among Black versus White decedents. Conclusions. While Black males were more likely to be victims of legal intervention deaths, PHW-coded variables in the NVDRS and death narratives suggest lower threat profiles among Black versus similar White decedents. The source of this greater risk remains undetermined.
The Gut Microbiome as a Promising Biomarker of Cancer Progression Among Female Never-smokers With Lung Adenocarcinoma
Authors: Otoshi Takehiro , Nagano Tatsuya , Park Jonguk , Hosomi Koji , Yamashita Tomoya , Tachihara Motoko , Tabata Tokiko , Sekiya Reina , Tanaka Yugo , Kobayashi Kazuyuki , Mizuguchi Kenji , Itoh Tomoo , Maniwa Yoshimasa , Kunisawa Jun , Nishimura Yoshihiro 
Published: May 2021

Abstract
Background: The gut microbiome plays an important role in the immune system and has attracted attention as a biomarker of various diseases, including cancer. As such, we examined the relationship between the gut microbiome and lung cancer progression. In addition, we assessed the correlation between the gut microbiome and epidermal growth factor receptor (EGFR) mutation status.Methods: Female never-smokers diagnosed with lung adenocarcinoma were consecutively and prospectively enrolled between May 2018 and August 2019. Fecal samples were collected within 1 month before or after diagnosis and before administration of any lung cancer treatment. Principal coordinate analyses were retrospectively performed using Bray-Curtis distance matrices to investigate the effects of clinical variables (age, body mass index, Tumor-Node-Metastasis stage, T category, N category, M category, primary tumor size, performance status, and EGFR mutation status) on the gut microbial community. A correlation analysis was also performed to determine the strength of association between the dominant taxonomy (comprising ≥1% of the relative abundance of bacterial DNA sequences) and clinical variables.Results: A total of 37 patients were enrolled. T category and primary tumor size were significantly correlated with the gut microbial community (p=0.018 and 0.041, respectively). At the genus level, a significant positive correlation was observed between the relative abundance of Faecalibacterium and both T category (correlation coefficient, R=0.51, p=0.0013) and primary tumor size (R=0.37, p=0.024), whereas a significant negative correlation was observed between the relative abundances of Fusicatenibacter and Bacteroides and T category (R=−0.35, p=0.034 and R=−0.32, p=0.05, respectively) and primary tumor size (R=−0.36, p=0.029 and R=−0.41, p=0.012, respectively). EGFR mutation status had no statistically significant effect on the gut microbial community (p=0.11). However, the relative abundances of Bifidobacterium and Faecalibacterium were significantly higher in EGFR mutation–negative patients than EGFR mutation–positive patients (p=0.012 and 0.041), whereas the relative abundance of Blautia was significantly lower in EGFR mutation–negative patients (p=0.036).Conclusions: This is the first study identifying the gut microbiome as a promising biomarker of lung cancer progression. Further elucidation of the role of the gut microbiome in lung cancer progression could facilitate development of new treatments for lung cancer.
Prediction of survival after eribulin chemotherapy for breast cancer by absolute lymphocyte counts and progression types
Authors: Morisaki Tamami , Kashiwagi Shinichiro , Asano Yuka , Goto Wataru , Takada Koji , Ishihara Sae , Shibutani Masatsune , Tanaka Hiroaki , Hirakawa Kosei , Ohira Masaichi 
Published: May 2021

Abstract
Background
In the RECIST diagnostic criteria, the concepts of progression by pre-existing disease (PPL) and progression by new metastases (PNM) have been proposed to distinguish between the progression types of cancer refractory to treatment. According to the tumor biology of cancer progression forms, the "PPL" form indicates invasion and the "PNM" form indicates metastasis. On the other hand, recent studies have focused on the clinical importance of inflammatory markers as indicators of the systemic tumor immune response. In particular, absolute lymphocyte counts (ALC) is an indicator of the host’s immune response. Thus, we developed a new measure that combined progression form with ALC. In this study, we clinically validated the combined assessment of progression form and ALC in eribulin chemotherapy.
Methods
From August 2011 to April 2019, a total of 486 patients with locally advanced or metastatic breast cancer (MBC) underwent treatment. In this study, only 88 patients who underwent chemotherapy using eribulin were included. The antitumor effect was evaluated based on the RECIST criteria, version 1.1. To measure ALC, peripheral blood samples collected before eribulin treatment were used. The cut-off value for ALC in this study was 1,500 /µL, based on previous studies.
Results
The PPL group (71 patients, 80.7%) had significantly longer PFS (p = 0.022, log-rank) and OS (p < 0.001, log-rank) than the PNM group (17 patients,19.3%). In the 51 patients with ALC < 1500/µl, the PPL group had a significantly better prognosis than the PNM group (PFS: p = 0.035, OS: p < 0.001, log-rank, respectively). On the other hand, in the 37 patients with ALC ≥ 1500/µl, the PPL group had a better OS compared to the PNM group (p = 0.055, log-rank), but there was no significant difference in PFS between the two groups (p = 0.541, log-rank). Furthermore, multivariate analysis that validated the effect of OS showed that high ORR and “high-ALC and PPL” were factors for a good prognosis (p < 0.001, HR = 0.321) (p = 0.036, HR = 0.290).
Conclusions
In breast cancer patients with eribulin chemotherapy, good systemic immune status, such as ALC ≥ 1500/µl, was associated with less progression, particularly metastasis, and better prognosis. Furthermore, the biomarker "high-ALC and PPL" was particularly useful as a prognostic marker following eribulin chemotherapy.
WITHDRAWN: HSPA2&nbsp;Expression Predicts Early Postsurgical Relapse and Promotes Tumor Cell Migration and Invasion in Pancreatic Cancer
Authors: Zhai Lu-Lu , Qiao Pei-Pei , Sun Yue-Shen , Tang Zhi-Gang , Ju Tong-Fa 
Published: May 2021

Abstract
Background: Heat shock protein A2 (HSPA2) is known to relate to the pathogenesis and progress of cancer. This study aimed to investigate the connection between HSPA2 and early postsurgical relapse, and the influences of HSPA2 on cell biological behaviors in pancreatic cancer (PC).Methods: Expression of HSPA2 in cancerous and noncancerous samples was determined by bioinformatics and immunostaining methods. The significance of HSPA2 expression in predicting early postsurgical recurrence was assessed. The biological role and potential mechanisms of HSPA2 in PC progression were uncovered by enrichment analysis. HSPA2 expression in human PC cells was detected by immunoblotting. Silencing of HSPA2 in BxPC-3 cells and upregulation of HSPA2 in PANC-1 cells were achieved with siRNA and overexpression plasmid, respectively, and then the impacts of HSPA2 downregulation and upregulation on cancer cell biological behaviors were estimated.Results: HSPA2 expression in tumor specimens was markedly elevated compared with nontumor specimens. HSPA2 overexpression could independently predict early postsurgical recurrence, and combined with malignant clinicopathological characteristics had greater predictive power and potential application value. Enrichment analysis revealed that HSPA2 expression was closely associated with PC progression. HSPA2 was expressed in BxPC-3, PANC-1 and SW1990 cells, with the highest and lowest levels in BxPC-3 and PANC-1 cells, respectively. Cell migration and invasion abilities were remarkably restrained in HSPA2-silenced BxPC-3 cells and significantly enhanced in HSPA2-overexpressed PANC-1 cells.Conclusion: HSPA2 expression predicts early postoperative recurrence and promotes cell migration and invasion, and is expected to become a useful molecular target of antitumor treatment in PC.
Reversible C–C Bond Formation Using Palladium Catalysis
Authors: Marchese Austin , Mirabi Bijan , Johnson Colton , Lautens Mark 
Published: May 2021

Abstract
A widely appreciated principle is that all reactions are fundamentally reversible. Observing reversible transition metal-catalyzed reactions, particularly those that include the cleavage of C–C bonds, are more challenging. The development of the palladium- and nickel-catalyzed carboiodination reactions afforded access to the syn- and anti-diastereomers of the iodo-dihydroisoquinolone products. Using these substrates, an extensive study investigating the catalytic reversibility of the C–C bond formation using a different palladium catalyst was undertaken. A combination of experimental and computational studies led to the discovery of a variety of new methodologies and concepts key to understanding the process of reversible C–C bond formations.
Fabrication of Visible Light Active Mn-Doped Bi2WO6-GO/MoS2 Heterostructure for Enhanced Photocatalytic Degradation of Methylene Blue
Authors: Tahir Noor , Zahid Muhammad , Bhatti Ijaz Ahmad , Jamil Yasir 
Published: May 2021

Abstract
The increase in environmental pollution has led to an increased investigation in the development of novel ternary photocatalytic systems for remediation. These Photocatalytic systems exhibit superior photocatalytic action for the removal of pollutants because of their visible light active bandgaps. A highly effective visible light active ternary heterojunction was fabricated using a hydrothermal method assisted by ultrasonication. Herein, we report the Insitu hydrothermal synthesis of Mn-doped Bi2WO6-GO/ MoS2 photocatalyst, efficiently exhibiting greater photocatalytic activity for the wastewater treatment under solar light. The binary metal sulphide (MoS2) used as a co-catalyst, acted as electron collector and Graphene oxide (GO) as a support material for interfacial electron transfer to and from bismuth tungstate and MoS2. The as-prepared samples were characterized using SEM-EDX, FT-IR, XRD, XPS, and UV–Vis techniques. The bandgap of the novel photocatalyst was found in the visible region (2.2 eV) which helped in suppressing photoinduced electron-hole pairs recombination. The ternary Mn-BMG showed 99% methylene blue removal after 60 minutes of sunlight irradiation at the optimum conditions of pH 8, catalyst dose 50 mg/100ml and initial MB concentration of 10ppm under sunlight irradiation. The Mn-BMG has proved to be an effective sunlight active photocatalyst that can be reused without substantial loss in photocatalytic efficiency.
Mitigating the Impacts of Meteorological Disasters During the Phenological Period for Geographical Indication Agricultural Growers by Using Adaptive and Resilient Coping Strategies
Authors: QIN Yuhan , Shi Xingmin , Li Xueping , Yan Jianwu 
Published: May 2021

Abstract
Developing geographical indication agricultural products will help to expand regional characteristic industries by taking actions that suit local circumstances. Improving the adaptability of geographical indication agricultural growers to cope with meteorological disasters is conducive to promoting the optimization of rural industrial structure and the implementation of rural revitalization strategy. Based on the field survey data of Shaanxi Province, this research uses the method of natural breaks to classify the resilience scores of meteorological disasters under the framework of Sustainable Livelihood Approach. Finally, the ordinal logistic regression model is used to quantitatively research how livelihood capital contributes to the resilience of kiwifruit growers to meteorological disasters during the phenological period. The results show that the perception of meteorological disasters by farmers does not significantly affect the resilience of farmers, and the impacts of different livelihood capitals on the resilience strategies of farmers are quite distinct: material capital, financial capital, social capital and human capital have significant positive impact on the resilience strategies of growers, while natural capital has a significant negative impact on the resilience strategies of growers. The results extend the theoretical foundation of resilience strategies for meteorological disasters in kiwifruit phenological period, and bring quantitative evidence linkage of livelihood capital and resilience strategies. Furthermore, the study emphasizes that the agricultural activities of kiwifruit growers during the phenological period should be combined with the livelihood capital guarantee measures, as well as a better financial environment should be created by government intervention. Paying attention to science popularization work of middle-aged and elderly growers, accelerating the linkages between the government and the mass, would help the government to obtain the best agricultural management methods.
Factors Associated with Prolonged Hospital Stay: a Retrospective Study for Imported Malaria Cases
Authors: Huang Liang , Jin Hong , Zhang Hong , Liu Yang , Shi Xinxing , Kang Xintong , Zeng Yilan , Wang Lin 
Published: May 2021

Abstract
Background

China had entered post-elimination era for malaria, however, the imported cases are continuously are a public health concern as the increasing number of cases. In this study we studied the potential predictive factors for prolonged hospital stay for imported malaria patients.
Material and Methods

We retrospectively collected patients of imported malaria cases data from 2017–2020 in our hospital. we analyzed the data from clinical, epidemiological, geographical, and seasonal points of view, and used cox proportional hazard model to find the predictive factors for prolonged hospital stay.
Results

We found most of imported cases were from Democratic Republic of the Congo(23%, 34/150) and most cases 74%(26/34) were infected by P. falciparum. Through Edwards Test, no significant seasonality of imported cases were found(χ2 = 2.51 p-value = 0.28). We found bacterial infection(HR = 0.58, p-value = 0.01) and thrombocytopenia(HR = 0.66, p-value = 0.02) were protective factors for discharge, that were, the risk factors for prolonged hospital stay.
Conclusions

The imported cases are the major risk of malaria in post-elimination era of China. The bacterial infection and thrombocytopenia were the risk factors for prolonged hospital stay.
Title Achieving Integrated Self-Directed Cancer Aftercare (ASICA) for Melanoma: How a Digital Intervention to Support Total Skin Self-Examination Was Used By People Treated for Cutaneous Melanoma
Authors: Reilly Felicity , Contstable Lynda , Brant William , Rahman Kaz , Durrani Amer , Burroughs Nigel , Proby Charlotte , Allan Julia , Johnston Marie , Johnston Derek , Walter Fiona , Murchie Peter 
Published: May 2021

Abstract
BackgroundMelanoma incidence has quadrupled since 1970 and melanoma is now the second most common cancer in individuals under 50. Targeted immunotherapies for melanoma now potentially enable long-term remission even in advanced melanoma, but these melanoma survivors require ongoing surveillance, with implications for NHS resources and significant social and psychological consequences for patients. Total skin self-examination (TSSE) can detect recurrence earlier and improve clinical outcomes but is underperformed in the UK. To support survivors, the Achieving Self-directed Integrated Cancer Aftercare (ASICA) intervention was developed to prompt and improve TSSE performance, with subsequent reporting of concerns and submission of skin photos to a Dermatology Nurse Practitioner (DNP). ASICA was delivered as a randomized pilot trial.MethodsThis paper reports on process evaluation. Data on participants’ demographics and the concerns they reported during the trial were tabulated and displayed using Microsoft Excel and SPSS. We explored which participants used ASICA, and how frequently, to report skin concerns. We also determined how the interactions had worked in terms of quality of skin photographs submitted, clinical assessments made by the DNP, and the assessments and decisions made for each concern. Finally, we explored significant events occurring during the trial. Data on participants’ demographics and the concerns they reported during the trial were tabulated and displayed using SPSS. A semi-structured interview was undertaken with the DNP to gain perspective on the range of concerns presented and how they were resolved.Results Of 121 recruited melanoma patients receiving ASICA for 12 months, 69 participants submitted a total of 123 reports detailing 189 separate skin-related concerns and including 188 skin photographs. Where participants fully complied with follow-up by the DNP, concerns were usually resolved remotely, but 19 (10.1%) were seen at a secondary care clinic and 14 (7.4%) referred to their GP. 49 (25.9%) of concerns were not completely resolved due to partial non-compliance with DNP follow-up.ConclusionMelanoma patients randomized to the ASICA intervention were able to report skin-related concerns that could be resolved remotely through interaction with a DNP. Feasibility issues highlighted by ASICA will support further development and optimization of this digital tool.
Oncogenic BRAF Induces Whole-Genome Doubling Through Suppression of Cytokinesis
Authors: Darp Revati , Vittoria Marc , Ganem Neil , Ceol Craig 
Published: May 2021

Abstract
Melanomas and other solid tumors commonly have increased ploidy, with near-tetraploid karyotypes being most frequently observed. Such karyotypes have been shown to arise through whole-genome doubling events that occur during early stages of tumor progression. The generation of tetraploid cells via whole-genome doubling is proposed to allow nascent tumor cells the ability to sample various protumorigenic genomic configurations while avoiding the negative consequences that chromosomal gains or losses have in diploid cells. Whereas a high prevalence of whole-genome doubling events has been established, the means by which whole-genome doubling arises is unclear. Here, we find that BRAFV600E, the most common mutation in melanomas, can induce whole-genome doubling via cytokinesis failure in vitro and in a zebrafish melanoma model. Mechanistically, BRAFV600E causes decreased activation and localization of RhoA, a critical cytokinesis regulator. BRAFV600E activity during G1/S phases of the cell cycle is required to suppress cytokinesis. During G1/S, BRAFV600E activity causes inappropriate centriole amplification, which is linked in part to inhibition of RhoA and suppression of cytokinesis. Together these data suggest that common abnormalities of melanomas linked to tumorigenesis – amplified centrosomes and whole-genome doubling events – can be induced by oncogenic BRAF and other mutations that increase RAS/MAPK pathway activity.
Immune Cell Profiles of Metastatic HER2 Positive Breast Cancer Patients According To The Sites of Metastasis
Authors: Honkanen Tiia J , Luukkainen Milla E K , Tikkanen Antti , Karihtala Peeter , Mäkinen Markus , Väyrynen Juha P , Koivunen Jussi 
Published: May 2021

Abstract
Purpose: Recent works have characterized that metastatic site can affect the tumour immune profiles and efficiency of cancer immunotherapies. The prognosis of HER2 positive breast cancer is associated with the characteristics of the tumour immune microenvironment, with immunological cells playing a central role in efficiency of HER2 targeted antibodies. Here we investigated the prognostic significance of different metastatic sites and their correlation to tumour immune profiles in HER2 positive breast cancer treated with trastuzumab. Methods: We collected all (n=54) HER2 positive metastatic breast cancer patients treated with trastuzumab containing regimens at Oulu University Hospital 2009-2014. Pathological and clinical data were collected from electronic patient records. The tumour immune profiles were analysed from pre-treatment primary tumours using well-characterized immunological markers with computer-assisted immune cell counting. Results: Of the metastatic sites, only liver metastases were associated with poor prognosis (hazard ratio 1.809, 95% confidence interval 1.004 – 3.262), especially when presenting as the primary site of metastases. Of the other sites, pulmonary metastases characterized a patient profile with trend to improved survival. Of the studied tumour immunological markers, liver metastases had low densities of CD3+ T-cells (p=0.030) and M1-like macrophages in their primary tumours (p=0.025). Of the other studied markers and sites, pulmonary metastases had low STAB1+ immunosuppressive macrophage density in their primary tumours.Conclusions: Our results suggest that the site of metastasis is associated with prognosis in HER2 positive breast cancer, highlighted by the poor prognosis of liver metastases. Furthermore, liver metastases were associated with adverse tumour immune cell profiles.