bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and functional impact of chronotropic incompetence in amyloid cardiomyopathy: a multicentre analysis
Authors: Magrì Damiano , Ermolaev Nikita , Willixhofer Robin , Gallo Giovanna , Fiori Emiliano , Maruotti Antonello , Fantozzi Paolo , Castiglione Vincenzo , Capelle Christophe D J , Kronberger Christina , Vergaro Giuseppe , Passino Claudio , Salvioni Elisabetta , Del Torto Alberico , Baggiano Andrea , Contini Mauro , Emdin Michele , Barbato Emanuele , Badr Eslam Roza , Agostoni Piergiuseppe 
Published: December 2024

BackgroundLittle evidence is available about heart rate (HR) response to exercise as well as its relationship with functional capacity in amyloid cardiomyopathy. Then, in a multicentre cohort of patients with amyloid cardiomyopathy, we investigated the prevalence of chronotropic incompetence (CI) and its relationships with cardiopulmonary exercise testing (CPET) variables.MethodsData from 172 outpatients with amyloid cardiomyopathy who performed a maximal CPET and who had no significant rhythm disorders were analysed.ResultsThe prevalence of CI differed depending on the age-predicted peak HR (pHR%) cut-off value adopted, ranging from 16% to 59%. pHR% correlated non-linearly with peak oxygen uptake (pVO2), either as expressed as a percentage of the maximum predicted or as mL/kg/min (p<0.001). Although to a lesser extent, pHR% correlated inversely with ventilatory efficiency (p<0.001). A pHR%≤75% resulted in the most accurate cut-off value in identifying a moderate-to-severe exercise impairment (sensitivity 72%; specificity 73%; area under the curve 77.2%).ConclusionsCI is prevalent in patients with amyloid cardiomyopathy in sinus rhythm, its percentage varying according to the pHR% cut-off value. A blunted exercise-induced HR response correlated with a poor exercise capacity even in this setting of patients, a pHR%≤75% cut-off value being possibly useful in centres without CPET availability to identify a significant exercise impairment.
Optimal surgical timing for congenital diaphragmatic hernia in a non-ECMO center: a retrospective study
Authors: Feng Zhong , Wei Yan-Dong , Wang Ying , Li Jing-Na , Liu Chao , Zhang Hui , Wang Fei , Wu Tao , Jiang Yu-Lin , Ma Lishuang 
Published: December 2024

BackgroundThis study aims to address the timing of repair for severe congenital diaphragmatic hernia (CDH) without the use of extracorporeal membrane oxygenation (ECMO) and to determine the feasibility of an earlier intervention to avoid deaths associated with non-repair in patients who are more challenging to stabilize without ECMO.MethodsThis single-center retrospective study was conducted on neonates with CDH from 2013 to 2023. Based on the timing of surgery, the patients were classified into three groups: <24 hours (group A), 24–48 hours (group B) and ≥48 hours (group C). The 90-day survival rates were analyzed using Kaplan-Meier curves and compared among groups via log-rank tests. The independent factors related to survival assessed using the multivariate Cox regression model.ResultsOf 132 CDH infants, the overall 90-day survival rate was 81.8% (108/132), with a median operative time of 26.00 (24.00, 38.50) hours. A significant difference was observed in the 90-day survival rate among the three groups: 60.5% (23/38) in group Avs.91.3% (74/81) in group Bvs.84.6% (11/13) in group C (log-rankp<0.001). In mild and severe cases and those with an oxygen index ≥7.5, group A resulted in significantly reduced survival rates. Multivariate Cox regression analysis indicated that surgical timing <24 hours remained an independent mortality-related risk factor in infants with CDH.ConclusionsRepair surgery should be performed at least 24 hours after birth. The optimal timing for CDH neonates in non-ECMO centers appears to be 24–48 hours after birth, which can prevent the loss of treatment opportunities for severe cases.
Comprehensive Analysis of Thrombotic Microangiopathy Following Renal Transplantation
Authors: Fattal Ittai , Steinmetz Tali , Donin Natalie , Tobar Ana Foigelman , Rozen-Zvi Benaya , Rahamimov Ruth , Nesher Eviatar , Shirazi Idit , Mor Eytan , Babai Ilan , Fishelson Zvi 
Published: December 2024

Background: Thrombotic microangiopathy is a severe complication of renal transplantation. Little is known about risk factors, incidence of autoantibodies against complement components, and prognosis.Methods: Clinical and laboratory data were retrospectively collected for 13 patients diagnosed with post‐transplant thrombotic microangiopathy (PT‐TMA) in 2011–2018. Enzyme‐linked immunosorbent assay (ELISA) results were compared to transplant recipients without PT‐TMA and healthy controls.Results: Nine patients (69%) had potential PT‐TMA risk factors other than exposure to calcineurin inhibitors (CNIs). Stratification by time to PT‐TMA yielded two groups. Patients diagnosed within 6 months of transplantation (n = 6) were characterized by positive donor‐specific antibody (DSA) test, complement‐associated renal disease, and acute rejection. Two had IgG and IgA autoantibodies to complement Factors H and I, respectively. Patients diagnosed ≥ 3 years after transplantation (n = 7) had a high rate of infection. Renal biopsy yielded dense deposits in 6 patients, and only one with primary immune complex renal disease. Within 2 years, graft failure requiring dialysis occurred in 6 patients (46%). Three patients with early‐onset PT‐TMA showed improved renal function and remained stable under eculizumab treatment. Epstein–Barr virus (EBV)–associated post‐transplant lymphoproliferative disorder (EPTLD) developed in 3 patients, 2 of whom had received eculizumab for more than 5 years. Five patients (39%) died during follow‐up.Conclusion: In this study, PT‐TMA was associated with other risk factors besides CNI exposure, with differences by time of onset from transplantation. Prognosis was generally poor but better for early‐onset PT‐TMA managed with eculizumab. The development of late EPTLD in 3 patients raises concerns.
Law Wars: Academia and the Manufacture of International Humanitarian Law
Authors: Wilson Page 
Published: December 2024

Abstract
Despite the emergence of much critical discourse on the conventional history of international humanitarian law (IHL) over the last decades, the way in which this conventional history is told and re-told remains virtually unaltered in one key area of dissemination: teaching materials. By conducting an in-depth examination of these materials, this article uncovers the techniques used over time to generate and perpetuate the conventional IHL history. In so doing, it helps to explain how and why the conventional IHL history continues largely unchanged in textbooks to this day.
Consensus, Disagreement, and the Criteria of Authenticity
Authors: Archer Joel 
Published: December 2024

Abstract
Recent scholarship has challenged the use of the so-called ‘criteria of authenticity’ in historical Jesus studies. One common argument draws attention to the fact that those who employ the criteria have produced an abundance of radically incompatible portraits of Jesus. The failure to generate any significant consensus in Jesus studies is therefore attributed to the criteria themselves. In response, I distinguish three versions of this line of reasoning, and I argue that none is persuasive. Scholarly disagreement, I argue, is ubiquitous across academic fields, and historical Jesus studies is not unique in this respect. There may be compelling reasons to discard or downplay the criteria of authenticity, but scholarly disagreement is not among them.
On the Margins of Emancipation: the Ambivalence of the Struggles of Evictees from the ZACA Project in Ouagadougou (Burkina Faso)
Authors: Lefebvre Félix 
Published: December 2024

Abstract
In Ouagadougou, the capital of Burkina Faso, the ZACA project, an urban renewal project, involved the destruction of inner-city neighbourhoods, and the displacement of their 12,000 inhabitants, mostly to outlying areas. Similar to other instances of forced evictions and displacements in metropolitan areas, this project has been widely used as an indicator of urban inequality, demonstrating the seizure of city centres by the upper classes and the prioritization of exchange value in neoliberal urbanism. It has also generated impulses for change through the promotion of new lifestyles, notably through the unprecedented communication campaign entrusted to the Synergie agency. In the face of this strategy, which emphasised the “modernity” of the project, tradition seemed to be an issue of struggle for the inhabitants, strongly emphasised in some speeches, and the customary authorities appeared as key actors whose support was sought by the various sides. While these injunctions may have seemed violent to a large part of the inhabitants of the zone and may partly explain the violent mobilisations that took place against the project, they may have constituted desirable horizons for others, especially the youth, making the social consequences of the ZACA project more ambivalent. By examining the testimonies of a father and his son evicted from the ZACA more than ten years after the event, and other field data, we will see that the reading of these events differs according to generation, revealing the importance of age-related inequalities in Burkinabè society. A radical change such as the expulsion from the neighbourhood of origin, if it consisted in an undeniable spatial marginalisation, could also have allowed the son to reshuffle the cards of social determinism, which he saw as a means of emancipation. In the end, this article argues for a complex reading of the accumulation of inequalities in urban societies, out of univocal logic.
A Historical Perspective on Political Culture in Contemporary African Politics
Authors: Nzally Jimmy Hendry 
Published: December 2024

Abstract
This article offers a historical but critical perspective on the influence of colonisation on political cultures in African states. It seeks to interrogate how colonialism has influenced Africa’s political systems. There is little literature that exists to explain the influence of colonialism on contemporary African politics. As an oppressive system, colonialism was rooted in white dominance, “racial hierarchy”, and exploitation. This led to the setting up of coerced institutionalised colonial systems of government. Notable examples were the British indirect rule system and assimilation by the French. This encounter led to the dismantling of Africa’s precolonial traditional systems of governance and their replacement with oppressive colonial systems. This article argues that colonial structures led to the instituting of, among other things, ethnic fragmentation, one-party states and military takeovers. This underpins “contemporary” discourse as it relates to democratic and non-democratic political cultures in Africa.
The main sources used in this study are literature studies, but the article also uses a variety of other sources to investigate political cultures. This includes analysing reports and historiographical and postcolonial theorising. The article makes a unique contribution to colonial, postcolonial and, more so, contemporary discourse on Africa’s political culture. Using the framework of Almond and Verba (1963), the article identifies three classifications of political culture: participant, subject and parochial. Thus, the article not only to applies this theoretical framework as it is but adapting it to the African context. It includes a salient focus on The Gambia’s 2016 presidential elections, which led to the democratic transition from autocracy.
Against Isolation: Multilingualism, Transnationalism and Literary Dialogue in Dutch–Afrikaans Formations. A Report with Critical Reflections on a Research Programme
Authors: T’Sjoen Yves 
Published: December 2024

Abstract
This research report pushes back against isolationist accounts of linguistic autonomy, not only in Afrikaans, but across languages and literary traditions. Starting with a focus on recent interactions between Afrikaans and Dutch literary polysystems (both in the Netherlands and Flanders), it combines a critical perspective on ‘minor literatures’ with methods based in functional literary and cultural interactions. I propose a generalisable transversal and multi-linguistic approach to the study of global literary and linguistic polysystems. This contribution focuses especially on the potential of multilingualism and translation to generate literary histories that can accommodate international and cross-cultural networking and exchange, thereby to complicate separatist constructions of linguistic heritage and identity.
Testing an HPV Vaccine Decision Aid for 27- to 45-Year-Old Adults in the United States: A Randomized Trial
Authors: Thompson Erika L. , Luningham Justin , Alkhatib Sarah A. , Grace Jessica , Akpan Idara N. , Daley Ellen M. , Zimet Gregory D. , Wheldon Christopher W. 
Published: December 2024

Background In the United States, human papillomavirus (HPV) vaccination among 27- to 45-y-olds (mid-adults) is recommended based on shared clinical decision making with a health care provider. We developed a patient decision aid tool to support the implementation of this mid-adult HPV vaccination guideline. The purpose of this study was to evaluate the effect of a patient decision aid tool for HPV vaccination, HPV DECIDE, compared with an information fact sheet among mid-adults who have not received the HPV vaccine. Method Participants were recruited between December 2023 and January 2024. We used a randomized Solomon, 4-group, pretest/posttest design with mid-adults aged 27 to 45 y who were unvaccinated for HPV and balanced based on sex ( n = 612). The primary outcome was decisional conflict. Intermediate outcomes included knowledge, behavioral expectancies, self-efficacy, and perceived risk. Variables were measured using validated scales. Pretest sensitization was not present; intervention and control groups were compared. Fixed-effects inverse-variance weighting was used to pool effect estimates and determine meta-analytic statistical significance across tests with and without pretest controls. Results Participants in the intervention group had significantly lower total decisional conflict scores (B = −3.58, P = 0.007) compared with the control group. Compared with the control group, participants in the intervention group showed higher knowledge (B = 0.48, P = 0.020), greater intention to receive (B = 0.196, P = 0.049) and discuss the HPV vaccine (B = 0.324, P ≤ 0.001), and greater self-efficacy about HPV vaccine decision making (B = 3.28, P = 0.043). There were no statistically significant results for perceived risks of HPV infection. Conclusions The HPV DECIDE tool for mid-adult HPV vaccination shows promise for immediate reductions in decisional conflict and improvement in knowledge, intentions, and self-efficacy about the HPV vaccine. Future studies are warranted to evaluate the effectiveness of this patient decision aid tool in real-world settings. Highlights Shared clinical decision making is recommended for HPV vaccination with mid-adults. A patient decision aid for HPV vaccination reduced decisional conflict for mid-adults. The HPV vaccine patient decision aid was acceptable to mid-adults.
Safety and effectiveness of ataluren in patients with Duchenne muscular dystrophy: single-center experience from Saudi Arabia
Authors: Ahmad Mushtaha , ElRasoul Alaa , Sedayou Raneem , Tamboosi Mohammed , Mahroos Hanan , Alrashed Shaimaa , Tunkar Mariam , Alzahrani Faisal , Alharbi Mohammed , Aljehani Mona , Alahmari Mousa , Alqarni Khalid , Gashlan Maha , Yilmaz Berna Seker , Alshaikh Nahla M. 
Published: December 2024

Objective Duchenne muscular dystrophy (DMD) is a rare X-linked neurodegenerative disorder caused by mutations in the DMD gene. This study examined the efficacy and safety of ataluren, the first oral treatment for DMD with nonsense mutations (nmDMD), in patients in the Middle East. Methods This retrospective longitudinal study assessed the outcomes of seven boys with nmDMD who received treatment with ataluren and follow-up at a single center since 2016. Results The median patient age at treatment initiation was 8.04 years (range: 3.3–9.92), and the median duration of exposure was 3.95 years (interquartile range = 4.42 years). Five patients were still ambulatory at the last follow-up. Ataluren was more effective in individuals with baseline 6-min walking distance (6MWD) ≥300 m, as these patients had smaller declines in 6MWD and North Star Ambulatory Assessment scores. Pulmonary function was well preserved in all patients, with no patients having forced vital capacity <60% at their last follow-up. Six patients maintained normal cardiac function, whereas one patient developed heart failure before starting ataluren treatment. Conclusions Our results demonstrated both the efficacy and safety of ataluren. Early initiation of ataluren treatment delayed the loss of ambulation and cardiorespiratory milestones.
Persistence of HPV in cervical smears of vaccinated WLWH support for combined molecular testing and cytology screening
Authors: Pereira Milena Siqueira , Cavalcanti Silvia Maria Baeta , Haddad Kury Charbell Miguel , da Rocha Willker Menezes , Varella Rafael Brandão 
Published: December 2024

Background Human papillomavirus (HPV) infection profoundly affects women living with HIV (WLWH). This infection leads to cervical cancer (CC) and increased mortality. Methods This study monitored HPV infection in WLWH in Rio de Janeiro, Brazil, before (T1) and after (T2) 4 years of vaccination. HPV genotyping and the presence of intraepithelial lesions were investigated at both time points. Results Among the 156 WLWH who received the quadrivalent HPV vaccine (4vHPV) at T1, 30 (19.2%) were initially found to have HPV DNA. After vaccination, only three (7%) of those who were HPV-negative at T1 tested positive for HPV. Most women who tested positive for HPV DNA at T1 had normal Pap smear results. However, this cohort also demonstrated a significant increase in cases of atypical squamous cells of uncertain significance and cervical intraepithelial neoplasia in PCR-negative HPV DNA samples at T2 ( p < .01). Conversely, women who initially tested negative for HPV DNA continued to exhibit normal Pap smear results in 2018 ( p < .01). Conclusions This study highlights the persistence of HPV in WLWH despite vaccination and underscores the importance of continued molecular and cytologic screening. The findings enhance our understanding of vaccine effectiveness in this population and emphasize the need for tailored preventive strategies.
Efficacy and safety of a dedicated venous stent for the treatment of iliofemoral venous obstruction: A single center experience
Authors: Huang Yulong , Xie Xinsheng , Huang Guoqiang , Hong Xiang , Hong Shichai , Fu Weiguo , Lu Weifeng 
Published: December 2024

Background Endovascular recanalization with venous stenting is the preferred treatment for iliofemoral venous obstruction. We reviewed our institutional experience and mid-term outcomes with endovascular therapy for iliofemoral venous obstruction using the VenovoTM Self-expanding Venous Stent (BARD Peripheral Vascular, Inc., Tempe, AZ, USA). Methods Between October 2022 and March 2024, patients with iliofemoral venous obstruction treated with VenovoTM Self-expanding Venous Stents were retrospectively analyzed. Patients were monitored at 3, 6, and 12 months. The primary endpoint was 12-month primary patency, defined as computed tomography venography-derived stenosis <50% and no target venous revascularization. Secondary endpoints included stent intimal hyperplasia and pain venous clinical severity scores (VCSSs). Results We evaluated 51 limbs from 40 patients (mean age: 61.7 ± 10.7 years; 26 females), including three acute deep venous thrombosis (DVT)cases, six post-thrombotic syndrome (PTS) cases, and 42 non-thrombotic iliofemoral vein lesion cases. All (100%) underwent successful endovascular treatment, with five undergoing combined stent deployment. The interventional operation-related complication rate was 1/51 (1.96%). The median follow-up was 14.6 months (range: 12–18 months). The primary patency rate at 1 year was 90%. Freedom from stent intimal hyperplasia at 12 months was 74.51% (38/51), and 3.92% (2/51) had in-stent stenosis >50%, which was reduced after high-pressure balloon dilation at 6 months. The mean VCSS decreased from a baseline of 13.1.7 ± 3.7 to 3.3 ± 1.6 at 12 months ( p < .0001). No complications were noted during follow-up. Conclusions Stenting iliofemoral venous obstruction using the VenovoTM Self-expanding Venous Stent appears to be safe and effective, with a high rate of 1-year clinical patency and a low reintervention rate.
Treatment of symptomatic bipartite patella in patients <21 years of age: A systematic review and treatment algorithm
Authors: Hines Kristen E , Liu David S , Steele Amy E , Gabriel Daniel , Prabhat Anjali , Yen Yi-Meng , Hogue Grant Douglas 
Published: December 2024

Purpose: The purpose of this study is to develop an evidence-based algorithm for the management of symptomatic bipartite patella in the pediatric and adolescent population based on a systemic review of the published literature. Methods: A systematic review of the literature was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines on PubMed and Embase, selecting for studies discussing the management of symptomatic bipartite patella. Results: Five studies met criteria, involving 315 knees (314 patients, average age 15.8 years). All patients presented with symptomatic bipartite patella and underwent an initial trial of conservative management. Seventy-six percent (239 knees) achieved full resolution of symptoms after conservative management at a median of 1.9 months. The remaining 76 knees (24.12%) had persistent symptoms requiring operative intervention. Surgical techniques included surgical excision, screw fixation, synchondrosis drilling, lateral release, and both arthroscopic and open interventions (92.1%). Most patients (90.79%) who underwent surgical intervention had partial or complete resolution of their symptoms. Seven of 76 knees (9.21%) needed management postoperatively for pain due to trauma, residual symptomatic ossicles, and hardware complications. Of these, four patients required reoperations (average 2 years). The remaining three patients had satisfactory outcomes with an additional course of conservative management and oral analgesics. Conclusion: Management of symptomatic bipartite patella should begin with a trial of conservative management. With refractory symptoms lasting greater than 3 months, surgical intervention may be considered with positive outcomes of partial or complete resolution of symptoms. The proposed algorithm is provided to guide physician management of symptomatic BPP in pediatric or adolescent patients.