bluuebunny/crossref_metadata_2025_split huggingface dataset:
The academic leadership framework: A guide for systematic assessment and improvement of academic administrative work
Authors: Niewiesk Stefan , Garrity‐Rokous E. Gates 
Published: March 2021

AbstractUniversities, particularly those in the United States, administer their operations through a multitude of disparate, siloed initiatives and processes. Approaches toward academic administrative leadership deserve a more concentrated focus. We propose a simple framework to provide a structure for the evaluation and improvement of administrative processes within a university. Based on an analysis of the literature on academic administration, and input from participants in academic leadership programs at Ohio State University, the proposed framework seeks to create a structure to harmonize administrative work across the university, afford consistency while allowing for unit‐specific adjustments, and offer a basis for defining and measuring ongoing improvement. The framework is organized in six domains of competence, with their respective competencies, which enables administrators to talk about their work using a common language. The framework is contrasted with other approaches to the evaluation of academic administrative work and some general conclusions about it uses are drawn.
Mid‐term outcomes and periodontal prognostic factors of autotransplanted third molars: A retrospective cohort study
Authors: Lucas‐Taulé Ernest , Llaquet Marc , Muñoz‐Peñalver Jesús , Nart José , Hernández‐Alfaro Federico , Gargallo‐Albiol Jordi 
Published: March 2021

AbstractBackgroundTooth autotransplantation is a valid method for replacing non‐restorable teeth. This study aimed to assess mid‐term survival and success of autotransplanted third molars and the clinical periodontal parameters and factors predicting successful periodontal attachment apparatus regeneration.MethodsIn total, 36 patients who had undergone extraction and subsequent autotransplantation of 36 third molars using virtual planning and computer‐aided rapid prototyping models by an oral surgeon and endodontist were eligible. Probing pocket depth (PPD), gingival recession (REC), clinical attachment level (CAL), pulpal and periapical healing, root resorption, and radiographic bone loss (RBL) were evaluated. Additionally, a questionnaire evaluated patient‐reported outcomes.ResultsThe mean age of the participants was 30.2 years with a mean follow‐up duration of 29.42 ± 14.56 months. The overall survival and success rates were 97.2% and 91.7%, respectively. No statistically significant differences were found in success and survival rates between open and closed apex groups or between compromised and intact buccal bone groups. No signs of pulp necrosis were found in the open apex group. Progressive replacement resorption was detected in one closed apex case. The mean PPD was 2.7 ± 0.45 mm for all transplanted teeth. REC was 0.13 mm higher in transplanted teeth than in previous hopeless teeth. CAL changes were neither clinically relevant (−0.17 ± 0.66 mm) nor statistically significant. The reported patient satisfaction was high.ConclusionsAutotransplantation of third molars is a predictable treatment method, with a 2.5‐year cumulative tooth survival and success of 97.2% and 91.7%, respectively, which were not influenced by recipient site integrity or root development.
Environments of the climatic optimum of MIS 11 in Britain: evidence from the tufa sequence at Hitchin, southeast England
Authors: Sherriff J. E. , Schreve D. C. , Candy I. , Palmer A. P. , White T. S. 
Published: March 2021

ABSTRACTMarine Oxygen Isotope Stage 11 (MIS 11, Hoxnian Interglacial) is an important interval for understanding both climate change in an interglacial partially analogous to the Holocene and the response of geomorphic processes, biotic systems, and hominin populations to these changes. In Britain, many sites correlated to MIS 11 have not been studied since the mid‐20th century and require reinvestigation, including the Hitchin tufa sequence, where a rich, non‐marine molluscan assemblage was originally recovered. Re‐excavation of the Hitchin tufa sequence for this study was focussed on combined sedimentological, micromorphological and geochemical analyses of the deposits. These indicate that tufa formation occurred within a perched springline system under temperate climatic conditions. Shifts between paludal and fluvial tufa facies within this system occur concomitantly with changes in carbonate geochemistry, representing increased humidity caused by a change in rainfall amount or seasonality. This research enables a correlation of the sequence to the climatic optimum of MIS 11c, the main warm phase of MIS 11, and permits further insights into temperature and hydrological changes in this interval by generating the first geochemical records of hydroclimatic evolution during the MIS 11 thermal maximum in Britain.
Stathmin expression in metastatic colorectal cancer
Authors: Leiphrakpam Premila D. , Lazenby Audrey J. , Smith Lynette M. , Brattain Michael G. , Are Chandrakanth 
Published: March 2021

AbstractObjectivesTo evaluate the relationship between stathmin expression and clinical outcome in colorectal cancer (CRC).BackgroundStathmin is a phosphoprotein involved in the regulation of microtubule dynamics and integration of intracellular signaling pathways. Stathmin has been implicated in the tumorigenesis of several cancers and is a potential therapeutic target.MethodsStathmin expression was evaluated in 25 metastatic CRC (mCRC) patients by immunohistochemistry (IHC). Ki67 IHC and TUNEL assay were also evaluated in mCRC for cell proliferation and apoptosis.ResultsHigh expression of stathmin was correlated with CRC metastasis (p = .0084), and significantly worse overall survival (OS) in CRC patients (p = .036). There was a significant increase in cell proliferation and a decrease in apoptosis in liver metastasis compared with CRC primary tumors as determined by Ki67 IHC and TUNEL assay (p < .0001). We also observed a significant positive correlation between stathmin level and cell proliferation in both CRC primary tumor and liver metastasis (p = .0429 to 0.0451; r = .4236 to .4288).ConclusionStathmin expression correlated with worse patient prognosis in mCRC patients and positively correlated with increased cell proliferation. Together, our findings indicate stathmin as a novel potential marker for increased risk of CRC‐specific mortality and identify stathmin as an attractive therapeutic target for the treatment of mCRC.
Assessing the immediate impact of COVID‐19 on surgical oncology practice: Experience from an NCI‐designated Comprehensive Cancer Center in the Northeastern United States
Authors: Gazivoda Victor , Greenbaum Alissa , Roshal Joshua , Lee Jenna , Reddy Lekha , Rehman Shahyan , Kangas‐Dick Aaron , Gregory Stephanie , Kowzun Maria , Stephenson Ruth , Laird Amanda , Alexander H. R. , Berger Adam C. 
Published: March 2021

AbstractBackgroundThe effects of the coronavirus disease 2019 (COVID‐19) pandemic on surgical oncology practice are not yet quantified. The aim of this study was to measure the immediate impact of COVID‐19 on surgical oncology practice volume.MethodsA retrospective study of patients treated at an NCI‐Comprehensive Cancer Center was performed. “Pre‐COVID” era was defined as January–February 2020 and “COVID” as March–April 2020. Primary outcomes were clinic visits and operative volume by surgical oncology subspecialty.ResultsAbouyt 907 new patient visits, 3897 follow‐up visits, and 644 operations occurred during the study period. All subspecialties experienced significant decreases in new patient visits during COVID, though soft tissue oncology (Mel/Sarc), gynecologic oncology (Gyn/Onc), and endocrine were disproportionately affected. Telehealth visits increased to 11.4% of all visits by April. Mel/Sarc, Gyn/Onc, and Breast experienced significant operative volume decreases during COVID (25.8%, p = 0.012, 43.6% p < 0.001, and 41.9%, p < 0.001, respectively), while endocrine had no change and gastrointestinal oncology had a slight increase (p = 0.823) in the number of cases performed.ConclusionsThe effects of the COVID‐19 pandemic are wide‐ranging within surgical oncology subspecialties. The addition of telehealth is a viable avenue for cancer patient care and should be considered in surgical oncology practice.
Psychometric Properties of the Syrian Arabic Version of the Impact of Event Scale–Revised in the Context of the Syrian Refugee Crisis
Authors: Grassi Michele , Pellizzoni Sandra , Vuch Marta , Apuzzo Gian Matteo , Agostini Tiziano , Murgia Mauro 
Published: March 2021

AbstractThe Impact of Event Scale–Revised (IES‐R) is a widely used self‐report questionnaire used to assess symptoms of posttraumatic stress disorder (PTSD). Although the IES‐R has been translated and validated in multiple languages, no previous version has employed the Arabic dialect commonly spoken in Syria. The present work aimed to assess the psychometric properties of a Syrian Arabic version of the IES‐R. Syrian citizens (N = 288) living in refugee camps in Turkey were administered the Syrian Arabic IES‐R as part of a humanitarian aid project focused on providing psychological assistance. The data were analyzed with respect to 10 previously published factor solutions. We found that the best‐fitting model was a four‐factor structure that included factors involving Avoidance–Numbing, Intrusion, Hyperarousal, and Sleep Disturbance. The model showed strong measurement invariance between male and female subsamples, allowing for meaningful comparisons of the factor means. Overall, the present findings support the validity of a new version of the IES‐R, which can be used by both researchers and clinicians responding to the urgent need for psychological care for Syrian refugees fleeing war‐related violence.
The Effects of Microaggressions on Depression in Young Adults of Color: Investigating the Impact of Traumatic Event Exposures and Trauma Reactions
Authors: Auguste Evan E. , Cruise Keith R. , Jimenez Maria C. 
Published: March 2021

AbstractMicroaggressions are a common way that individuals experience racism in the United States. The current study examined the extent to which microaggressions contribute to mental health difficulties, namely trauma reactions and depression, after controlling for other traumatic event exposures. We sought to address gaps in the literature by quantitatively assessing the associations among microaggressions, posttraumatic stress symptoms, and depression symptoms. Participants were 140 young adults of color (68.8% female) who were recruited online. Linear regression analyses evidenced that microaggressions were uniquely associated with depression symptoms, B = 0.27, after controlling for lifetime traumatic event exposures, with this association partially mediated by trauma reactions, B = 0.49. These results suggest that microaggressions are a clinically relevant factor in understanding mental health problems reported by Black, Indigenous, and People of Color in the United States and warrant analysis, assessment, and intervention through a trauma lens.
Incorporating Virtual Reality to Improve Otolaryngology Resident Wellness: One Institution's Experience
Authors: Weitzman Rachel E. , Wong Kevin , Worrall Douglas M. , Park Christopher , McKee Sean , Tufts Ryan E. , Teng Marita S. , Iloreta Alfred M. 
Published: March 2021

ObjectiveBurnout is defined as work‐related emotional exhaustion, depersonalization, and decreased sense of accomplishment. Virtual reality (VR) has emerged as an effective treatment modality for various conditions related to anxiety, however, few studies have assessed its role for stress management in residents. We hypothesize that VR‐based mindfulness meditation can reduce resident burnout in real‐world settings.Study DesignProspective randomized crossover trial.MethodsResident participants completed the validated Maslach Burnout Inventory (MBI). One group used a VR‐based meditation app; the second group received no intervention. After a 2‐month rotation, all subjects completed an MBI and crossed over to the other arm. Wilcoxon rank‐sum tests were used to compare MBI scores before and after intervention, and to compare results by gender and postgraduate year. Mann‐Whitney U tests were used to assess qualitative differences between participants.ResultsEighteen residents completed the study. Five participants were female and 13 were male. Weekly use of VR‐guided meditation and paced breathing was associated with a significant decrease in emotional exhaustion (P = .009), and on subgroup analysis, male gender specifically was associated with a decrease in emotional exhaustion (P = .027). In the post‐intervention survey, 42.9% subjects reported that VR encouraged them to employ paced breathing techniques, 71.4% reported that they would use the technology if regularly available, and 21.4% reported they would use paced breathing in the future.ConclusionVR‐based therapy may serve as a successful tool in stress management and reduce the rate of burnout among otolaryngology residents.Level of EvidenceNA Laryngoscope, 131:1972–1976, 2021
Surface runoff from an area undergoing soil rehabilitation after bauxite mining in southeastern Brazil
Authors: Spletozer Aline Gonçalves , da Silveira Lucas Jesus , Sato Aurora Yoshiko , Lorenzon Alexandre Simões , Zanuncio José Cola , Dias Herly Carlos Teixeira 
Published: March 2021

AbstractChanging hydrological processes and soil characteristics are of major environmental concern in surface mining. Runoff may be the best factor for determining the efficiency of rehabilitation after this type of mining, and needs more in‐depth studies, but the environmental factors require more attention in order to control that runoff. The objective of this study was to compare the runoff during post‐mining rehabilitation after the extraction of bauxite with that before mining, and to identify the factors that most affect it. Runoff from before the mining operations and during the rehabilitation after those operations were collected in seven plots in the area of a bauxite mine in southeastern Minas Gerais State, Brazil. The physical‐environmental and anthropic factors interfering with the runoff were characterized for both periods, and their results were submitted to principal component analysis to define the parameters, which most demand attention in the mining rehabilitation stage. This study provides the first records of runoff in the field in areas rehabilitated after surface mining in Brazil, where the runoff decreased (1.75‐times or 42.79%) from 0.76 to 0.30% of the precipitation during rehabilitation, compared to the reference area. The total porosity, density, and resistance of the soil, associated with the maintenance of slope, surface roughness, and vegetation cover, are the factors demanding more attention during the rehabilitation stage of surface mining in order to minimize runoff.
Simulation of the impacts of native vegetation and polyacrylamide on hydraulic properties and heavy metal concentrations at mine dumps
Authors: Zhou Tao , Su Zheng'an , He Zhouyao , Zhang Xiaobo , Wang Xiaoyi , Wang Junjie , Liu Yihan , Wu Zuo , Wang Lijuan 
Published: March 2021

AbstractThe ecological restoration of mine dumps is challenging because of the loose soil structure, toxic heavy metal, and severe soil erosion at such sites. The impacts of native grass and polyacrylamide (PAM) on the soil sediment concentration, hydraulic properties, and heavy metals at mine dumps were investigated via scouring tests with a flow discharge of 90 L min−1. In the initial stages of the tests, fluctuating decreasing trends in the soil sediment concentration, flow velocity, and flow Ni concentration were observed, while a fluctuating increasing trend was observed in the flow resistance f. After a period of adjustment, the steady‐state soil sediment concentrations, hydraulic properties, and Ni concentrations in the flow were attained. An increasing–decreasing trend for the V concentration and a decreasing–increasing trend for the Cu concentration in the flow were observed over time. In addition, Zn was not dissolved or transported by the overland flow. A significant correlation between the heavy metal concentration in the flow and soil sediment concentration was observed (p ≤  0.01). Both native grass and PAM could effectively control soil loss and change hydraulic properties by increasing the surface roughness. The steady‐state flow velocity of B5 was 1.11–1.36 times higher than in the other treatments, while the steady‐state resistance f of B5 was 12.54–45.02% lower than in the other treatments. However, the native grass and PAM had different effects on the transport of heavy metals. The native grass could effectively reduce the mobility of V, while the PAM could reduce the mobility of Cu and V.
Moisture Curable Hybrid Polyhydroxyurethanes from Sugar‐Derived Dicarbonates
Authors: Younes Georges R. , Maric Milan 
Published: March 2021

AbstractA new set of polyhydroxyurethanes (PHUs) is synthesized from bio‐based sorbitol bicarbonate (SBC) and mannitol bicarbonate (MBC). The synthesized dicarbonates are polymerized with two long chain diamines, telelechelic amine terminated poly(propylene glycol) (PPG), and poly(dimethylsiloxane) (PDMS). Despite the high melting points of SBC and MBC, PHU prepolymers are prepared in bulk at moderate temperatures of 60–100 °C. The structural and thermal properties of the resulting PHUs are qualitatively and quantitatively characterized in order to evaluate them as potential sealants and adhesives, and they are end‐capped with moisture curing agents and left to cure at ambient conditions (22 °C and 20–30% humidity) with the curing processes monitored rheologically. The chemical stability of the novel partially sustainable hybrid PHUs (HPHUs) in pure water is investigated to check the viability of applying them outdoors. Only SBC or MBC‐PDMS HPHUs are found to be hydrophobic with water contact angles of 105° and 109°, respectively, but they are brittle. Small and wide‐angle X‐ray scattering of these water‐resistant films show that they are potentially composed of three different phases due to microphase separation: the PDMS matrix, a hard segments phase, and a third phase mixing the PDMS diamine end‐segments and some dissolved hard segments.
A Phase 2 Proof‐of‐Concept, Randomized, Placebo‐Controlled Trial of CX‐8998 in Essential Tremor
Authors: Papapetropoulos Spyros , Lee Margaret S. , Versavel Stacey , Newbold Evan , Jinnah Hyder A. , Pahwa Rajesh , Lyons Kelly E. , Elble Rodger , Ondo William , Zesiewicz Theresa , Hedera Peter , Handforth Adrian , Elder Jenna , Versavel Mark 
Published: March 2021

AbstractBackgroundAvailable essential tremor (ET) therapies have limitations.ObjectivesThe objective of this study was to evaluate CX‐8998, a selective T‐type calcium channel modulator, in essential tremor.MethodsPatients 18–75 years old with moderate to severe essential tremor were randomized 1:1 to receive CX‐8998 (titrated to 10 mg twice daily) or placebo. The primary end point was change from baseline to day 28 in The Essential Tremor Rating Assessment Scale performance subscale scored by independent blinded video raters. Secondary outcomes included in‐person blinded investigator rating of The Essential Tremor Rating Assessment Scale performance subscale, The Essential Tremor Rating Assessment Scale activities of daily living subscale, and Kinesia ONE accelerometry.ResultsThe video‐rated The Essential Tremor Rating Assessment Scale performance subscale was not different for CX‐8998 (n = 39) versus placebo (n = 44; P = 0.696). CX‐8998 improved investigator‐rated The Essential Tremor Rating Assessment Scale performance subscale (P = 0.017) and The Essential Tremor Rating Assessment Scale activities of daily living (P = 0.049) but not Kinesia ONE (P = 0.421). Adverse events with CX‐8998 included dizziness (21%), headache (8%), euphoric mood (6%), and insomnia (6%).ConclusionsThe primary efficacy end point was not met; however, CX‐8998 improved some assessments of essential tremor, supporting further clinical investigation. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This article has been contributed to by US Government employees and their work is in the public domain in the USA.
Mitochondrial DNA insert into CD40 ligand gene‐associated X‐linked hyper‐IgM syndrome
Authors: Li Xuejing , Xu Dan , Cheng Beilei , Zhou Yunlian , Chen Zhimin , Wang Yingshuo 
Published: March 2021

AbstractBackgroundX‐linked hyper‐IgM (X‐HIGM), which results from mutations in the CD40LG gene located on chromosome Xq26.3, is the most common form of HIGM. To date, more than 130 variants of the CD40L gene have been reported. We described a patient with novel de novo nuclear mitochondrial DNA sequences (NUMTs) in the CD40LG gene that have resulted in X‐HIGM.MethodsWhole‐exome sequencing (WES) analysis was used to screen for causal variants in the genome, and the candidate breakpoint was confirmed by Sanger sequencing.ResultsA new mutation of CD40LG, which deletes A at position 17 followed by a 147‐nucleotide from mitochondrial DNA copies insertion in exon 1, was detected in a 20‐month‐old boy harbouring an X‐HIGM combined with immunodeficiency syndrome.ConclusionThis is one of the few cases of a human genetic disease caused by nuclear mitochondrial DNA sequences (NUMTs). The presented data serve to demonstrate that de novo NUMT transfer of nucleic acid is a novel mechanism of X‐HIGM.
Optimal design of dielectric flat lens utilizing Bayesian optimization
Authors: Kudo Koji , Morimoto Keita , Iguchi Akito , Tsuji Yasuhide , Kashiwa Tatsuya 
Published: March 2021

AbstractIn recent years, various kinds of optimal design approaches are intensively studied for exploring novel and higher performance microwave and optical devices beyond human knowledge. In this article, we first apply a design approach based on Bayesian optimization (BO) to design of dielectric flat lens which is expected to be used in microwave and millimeter wave region because of its excellent features, such as thin and light weight. BO is able to efficiently search optimal values of design variables compared with population based optimization, without requiring sensitivity analysis which is mandatory in the gradient method.
A novel antipodal tapered slot antenna integrated with half mode substrate integrated waveguide‐based bandpass filter for K and Ka band applications
Authors: P Prasanna Kumar , Saxena Prerna 
Published: March 2021

AbstractIn this article, we present a novel half mode substrate integrated waveguide (HMSIW)‐based bandpass filter fed antipodal tapered slot antenna. We employ a novel feed consisting of three horizontal slots with two gaps arranged periodically on the top metal layer of HMSIW to obtain |S11|<‐10 dB and |S21|≃0 dB over the passband from 21.6 to 40 GHz. We incorporate sinusoidal corrugations at the antenna outer edges along with ground plane slots. We control the operating bandwidth of the antenna over 21.6–40 GHz with |S11|<‐10 dB using the proposed feed. The antenna offers gain of 10–12.44 dB and stable radiation pattern over the controlled band. The proposed antenna, 16 × 30.3 × 0.254 mm3 in volume, is fabricated and tested for validation. The measurement results show good agreement with simulations. The proposed antenna compares favorably with the state‐of‐the‐art. It is compact and exhibits stable gain and stable radiation pattern over the controlled bandwidth.