bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvement of BNSGAII to Increase the Accuracy and Reduction of Feature Selection Subsets
Authors: Farimani Hojjat Farrahi , Bahrepour Davoud , Kamel Seyed Reza , Ghaemi Reza 
Published: March 2021

Abstract
Feature selection is a process for the elimination of irrelevant and redundant features from a dataset in order to improve learning performance in terms of accuracy and time to build a model from the subsets. The conventional techniques in this regard have limitations such as the high computational overhead for training, even in moderate datasets. Although attention has been paid to the development of rapid and accurate detection techniques, finding a dataset of features that could increase detection accuracy is paramount. The issue with feature selection is the NP-hard problem; therefore, an optimal solution cannot be guaranteed. The present study aimed to propose a new solution for the non-dominated sorting genetic algorithm (NSGA II) by making it binary through the Sigmoid transfer function and a thresholding device for binary feature selection in order to improve the performance in feature selection problems in terms of the accuracy and reduction of the subset dimensions. In addition, the efficiency of the proposed algorithm in reducing the mentioned parameters was measured through comparison with other methods in the four datasets of breast cancer, hepatitis, heart, and diabetes.
Assessing Health Seeking Behaviour and Malaria Prevention Practices Among Communities in Four Districts of the Volta Region of Ghana
Authors: Orish Verner N. , Maalman Raymond Saa-Eru , Donkor Otchere Y. , Ceruantes Barbara Yordanis Henandez , Osei Eric , Amu Hubert , Appiah Prince Kubi , Konlan Kennedy Diema , Mumuni Hadiru , Kim Eunji , Kim Siwoo , Jung Hajun , Ofori-Amoah Jones , Kofie Philip , Adjuik Martin , Alhassan Robert Kaba , Donkor Ernestina Safoa , Zottor Francis Bruno , Kweku Margaret , Amuna Paul , Kim So Yoo , Gyapong John Owusu 
Published: March 2021

Abstract
Background: Malaria is a preventable disease that causes huge morbidity and mortality in malaria-endemic areas especially among children and pregnant women. The malaria control program focuses on the prevention of mosquito bites using Insecticide Treated Nets (ITNs) and mosquito aerosol spray and coil, and prevention of severe disease among those infected through prompt and adequate treatment. The success of the malaria control program in Ghana is dependent on the malaria prevention practices of people in the community. Therefore, this study evaluated the malaria prevention practices of participants in four districts of the Volta Region of Ghana. Methods: This was a cross-sectional study conducted in Ketu South, Nkwanta South, Hohoe Municipality and Ho West districts of the Volta Region of Ghana. Questionnaire were administered to adults who consented to each household visited. Questions were asked on the socio-demographics and malaria prevention practices of the households. Data analysis was done using SPSS version 23 with frequency distribution done for all the variables. Pearson chi-square was used to determine the significant association between socio-demographics and malaria prevention practices, and logistic regression was used to analyze the strength of the association. Result: Of the 668 participants that had a fever within the past 3 days, 268 (40.1%) visited a patent medicine store and 156(23.4%) visited health facilities. Out of the 2493 participants; 2234 (89.6%) owned ITN and 1528 (68.4%) used ITN a night before this study, 768(30.8%) used mosquito aerosol spray and 368 (15%) used mosquito coil. More females significantly owned ITN than males (1293, 92.4%, p ≤0.001). Participants from Ketu South had 1.5 times higher odds of owning an ITN (AOR, 1.56 [95% 1.09-2.22]; p=0.01). Conclusion: There is high ownership of ITNs but relatively low utilization among the community members. Education on malaria prevention practices should be intensified and continuous among the population of the Volta Region to ensure the success of malaria control in the region.
Association Between Regular Arrangement of Collecting Venules and Helicobacter Pylori Status in Routine Endoscopy
Authors: Yuan Cong , Lin Xue-Mei , Ou Yan , Cai Lin , Cheng Qian , Zhou Ping , Liao Juan 
Published: March 2021

Abstract
Background: The sensitivity of regular arrangement of collecting venules (RAC)-positive pattern for predicting Helicobacter pylori (H. pylori)-negative status greatly altered from 93.8% to 48.0% in recent two decades of various studies, while the reason behind it remained obscure. The aim of this study was to investigate the value of RAC as an endoscopic feature for judging H. pylori status in routine endoscopy and reviewed the underlying mechanism.Methods: A prospective study with high-definition non-magnifying endoscopy was performed. RAC-positive and RAC-negative patients were classified according to the collecting venules morphology of the lesser curvature in gastric corpus. Gastric biopsy specimens were obtained from the lesser and greater curvature of corpus with normal RAC-positive or abnormal RAC-negative mucosal patterns. H. pylori status was established by hematoxylin and eosin staining and immunohistochemistry. Results: 41 RAC-positive and 124 RAC-negative patients were enrolled from June 2020 to September 2020. The prevalence of H. pylori infection in patients with RAC-positive pattern and RAC-negative pattern was 7.3% (3/41) and 71.0% (88/124), respectively. Among all 124 RAC-negative patients, 36 (29.0%) patients were H. pylori-negative status. Ten patients (32.3%) demonstrated RAC-positive pattern in 31 H. pylori-eradicated cases. The sensitivity, specificity, positive predictive value, and negative predictive value of RAC-positive pattern for predicting H. pylori negative status were 51.4% (95%CI, 0.395-0.630), 96.7% (95%CI, 0.900-0.991), 92.7% (95%CI, 0.790-0.981), and 71.0% (95%CI, 0.620-0.786), respectively.Conclusions: RAC presence can accurately rule out H. pylori infection of gastric corpus, and H. pylori-positive status cannot be predicted only by RAC absence in routine endoscopy.Trial registrationThe present study is a non-interventional trial.
Immunogenicity and Efficacy Evaluation of Vero Cell-Adapted Infectious Bursal Disease Virus LC-75 Vaccine Strain in Ethiopia&nbsp;
Authors: Kebebe Wakjira , Bitew Molalegne , Dawo Fufa , Mammo Bedaso , Mohammed Hawa , Yami Martha , Getachew Belayneh , Abayneh Takele , Gelaye Esayas 
Published: March 2021

Abstract
Background: Infectious bursal disease virus (IBDV) is an avian viral pathogen that causes infectious bursal disease (IBD) of chickens. The disease is endemic in Ethiopia since 2002 and vaccination is the major means of disease prevention and control. IBD vaccine is produced in Ethiopia using primary chicken embryo fibroblast (CEF) cell; which is time-consuming, laborious, and uneconomical. The present study was carried out to develop cell-based IBDV LC-75 vaccine using Vero cells, and to evaluate the immunogenicity and protection level.Results: Identity of the vaccine seed was confirmed using gene-specific primers using reverse transcription polymerase chain reaction. Confluent monolayer of Vero cells was infected with vaccine virus and serial passage continued till passage ten. Characteristic virus induced cytopathic effect was observed starting from passage 2 on the third day post-infection. The infectious titer of adapted virus showed a linear increment along the passage level. Virus induced specific antibody was determined using indirect ELISA after vaccination of 14 days old chicks through ocular route. Accordingly, the antibody titer measured from Vero cells vaccinated chicks revealed similar level with the currently available CEF cell-based vaccine. Chicks vaccinated with Vero cell adapted virus showed complete protection against very virulent IBDV, while unvaccinated group had 60% morbidity and 25% mortality.Conclusions: The IBDV vaccine strain well adapted on Vero cells and found to be immunogenic induces antibodies development and successfully protects chicks against challenging with the circulating field IBDV isolate. Hence, it is recommended to produce IBD vaccine using Vero cell culture with enough quantity to conquer the limitations using CEF cells and thus to vaccinate chicks to protect against IBDV infection.
Spreading Misinformation on Exercise and Health: Analysis of Instagram´s Profiles
Authors: Marocolo Moacir , Meireles Anderson , Souza Hiago Leandro Rodrigues , Mota Gustavo R. , Arriel Rhaí André , Leite Laura Hora Rios 
Published: March 2021

Abstract
Instagram (IG) reaches millions of people, sharing personal content, and also all kinds of information, including those related to exercise and health. However, scientific quality of the posted information is questionable. Thus, this study aimed at analyzing whether exercise and health information posted by main IG Brazilian influencers have technical-scientific accuracy. A personal IG account was created to identify Brazilian IG profiles. The inclusion criteria of the accounts were: 1) having 50% of all the shared posts indeed related to topics about exercise and heath, such as nutrition, health and wellness, medicine and/or physical fitness; and 2) having over followers 100,000. A qualitative analysis revealed that ~75% of the account´s administrators were academically/professionally qualified. However, out of all the posts, only 13 (~2.7%) cited a reference endorsing the information. Moreover, the higher quality of the posts was directly associated with the higher educational qualification of the influencers (r=0.451; p<0.01). Nevertheless, the number of followers was inversely correlated with the educational qualification of the influencers (r=-0.450; p<0.01) and quality of the posts (r=-0.348; p=0.047). We conclude that main IG Brazilian influencers disseminate low-quality information about exercise and health, contributing to the wide-spreading of misinformation to millions of followers.
Treatment of alcohol withdrawal syndrome in the emergency department: a rapid review
Authors: Koh Justin Jek-Kahn , Malczewska Madeline , Doyle-Waters Mary M. , Moe Jessica 
Published: March 2021

Abstract
Background

Patients who experience harms from alcohol and other substance use often seek care in the emergency department (ED). Many ED patients with alcohol use disorder will require management of alcohol withdrawal. ED clinicians are responsible for risk-stratifying these patients under time and resource constraints and must reliably identify those who are safe for outpatient management versus those who require more intensive levels of care. Published guidelines for alcohol withdrawal are largely limited to the primary care and outpatient settings, and do not provide specific guidance for ED use. The purpose of this review was to synthesize published evidence on the treatment of alcohol withdrawal syndrome specifically in the emergency department setting.
Methods

We conducted a rapid review by searching MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials (1980 to 2020). We also searched for grey literature on Google and hand-searched the conference abstracts of relevant addiction medicine and emergency medicine professional associations (2015 to 2020). We included interventional and observational studies that reported outcomes of clinical interventions aimed at treating alcohol withdrawal syndrome in adults in the ED.
Results

We identified 13 studies that met inclusion criteria for our review (7 randomized controlled trials and 6 observational studies). Most studies were at high/serious risk of bias. We divided studies based on intervention and summarized evidence narratively. Benzodiazepines decrease alcohol withdrawal seizure recurrence, but no clear evidence supports the use of one benzodiazepine over another. It is unclear if symptom-triggered benzodiazepine protocols are effective for use in the ED. More evidence is needed to determine if phenobarbital, with or without benzodiazepines, can be used safely and effectively to treat alcohol withdrawal in the ED. Phenytoin does not have evidence of effectiveness at preventing withdrawal seizures in the ED.
Conclusions

Few studies have evaluated the safety and efficacy of pharmacotherapies for alcohol withdrawal specifically in the ED setting. Benzodiazepines are the most evidence-based treatment for alcohol withdrawal in the ED. Pharmacotherapies that have demonstrated benefit for treatment of alcohol withdrawal in other inpatient and outpatient settings need to be evaluated in the ED setting before routine use.
Effect of ultrasonic impact time on Microstructure and properties of 7A52 aluminum alloy tandem MIG welded joint
Authors: Chen Furong , Yang Yihang , Li Nan 
Published: March 2021

Abstract
7A52 (Al-Zn-Mg-Cu) alloy is a high-strength aluminum alloy, its welded joints are often accompanied by defects such as poor wear resistance and low fatigue strength. Herein, we try to optimize the welded joint of 7A52 aluminum alloy by using ultrasonic impact treatment (UIT). Generally, the mechanical properties such as microhardness and fatigue strength of the welded joint after UIT will be improved. 7A52 aluminum alloy tandem metal inert gas (MIG) welded joints with UIT time per unit area of 2.5 min, 5 min, 10 min, 15 min, 30 min, and 75 min were studied. Through the surface topography, microstructure observation, and mechanical properties test, the time parameters of excessive treatment, lack of treatment, and proper treatment were selected, and the effects of UIT, excessive treatment, lack of treatment, and proper treatment on fatigue strength were analyzed. Test results show that, the mechanical properties of welded joints after UIT are improved. The proper treatment time is 15min and its fatigue strength is 37.86MPa, respectively under the stress ratio of 0.1. Compared to the original welding condition with a fatigue strength of 28.61MPa, the fatigue strength of the welded joints of 7A52 aluminum alloy increased by 32.33%. The largest percentage of grain size reduction occurs when the UIT is 15 min. Moreover, excessive treatment and lack of treatment will not further refine the grains and optimize the mechanical properties.
An integrated method for optimized identification of effective natural inhibitors against SARS-CoV-2 3CLpro
Authors: Liao Qi , Chen Ziyu , Tao Yanlin , Zhang Beibei , Wu Xiaojun , Wang Zhengtao , Yang Li , Wang Qingzhong 
Published: March 2021

Abstract
The current severe situation of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has not been reversed and posed great threats to global health. Therefore, there is an urgent need to find out effective antiviral drugs. The 3-chymotrypsin-like protease (3CLpro) in SARS-CoV-2 serve as a promising anti-virus target due to its essential role in the regulation of virus reproduction. Here, we report an improved integrated approach to identify effective 3CLpro inhibitors from effective Chinese herbal formulas. With this approach, we identified the 5 natural products (NPs) including narcissoside, kaempferol-3-O-gentiobioside, rutin, vicenin-2 and isoschaftoside as potential anti-SARS-CoV-2 candidates. Subsequent molecular dynamics simulation additionally revealed that these molecules can be tightly bound to 3CLpro and confirmed effectiveness against COVID-19. Moreover, kaempferol-3-o-gentiobioside, vicenin-2 and isoschaftoside were first reported to have SARS-CoV-2 3CLpro inhibitory activity. In summary, this optimized integrated strategy for drug screening can be utilized in the discovery of antiviral drugs to achieve rapid acquisition of drugs with specific effects on antiviral targets.
FEM Based Study for Estimation of Applanation Force and Influence of Intraocular Pressure on Tonometry
Authors: Bhat Bharathi , Poojary Rakshath G. , Prabhu Gopalakrishna , Ve Ramesh S. 
Published: March 2021

Abstract
Purpose: Excess force on cornea during eye care testing procedure such as tonometry may damage the internal structure of eye or may result in erroneous results. The proposed work can be utilized or incorporated as an additional feedback mechanism in the technology innovation of design of eye care instruments. Method: This work is focused on biomechanical simulation of human eye to determine applanation force on cornea and also to find the influence of intraocular pressure (IOP) of eye on Tonometry. Results: The results summarise that force applied by the tonometer will increase linearly for increase in deformation of cornea and the junction of cornea and sclera will undergo maximum deformation and hence will experience maximum stress compared to the centre of cornea where tonometer applanates the cornea. Conclusion: The tonometry will result in deformation of cornea in vertical elongation and the maximum stress is concentrated at the tonometer periphery as well as at the junction of cornea and sclera. The investigation also report that rise in IOP of eye demands higher force of applanation to get the prescribed deformation of cornea.
Peripheral Inflammation Is Associated With Brain SPECT&nbsp;Perfusion Changes in Schizophrenia
Authors: Fond Guillaume , GAROSI Alexandra , FAUGERE Mélanie , Campion Jacques-Yves , LANCON Christophe , Boyer Laurent , RICHIERI Raphaelle , Guedj Eric 
Published: March 2021

Abstract
Purpose. Peripheral inflammation is frequent in schizophrenia, and plays a major role in pathophysiology, prognosis, and persistence of psychotic symptomatology under treatment. Aim. To determine the correlation between peripheral inflammation and brain SPECT perfusion in stabilized antipsychotic-treated outpatients with schizophrenia, and to determine whether such perfusion changes are correlated to persistent symptoms. Methods. Highly sensitive C-reactive protein blood level (hs-CRP) and brain SPECT perfusion were assessed in 137 stabilized outpatients with schizophrenia. Whole-brain voxel-based associations were searched with SPM between SPECT perfusion and hs-CRP (correlation analysis to quantitative levels and between-group analysis according to a threshold of 3mg/L). The identified clusters were secondarily correlated with clinical symptoms.Results. After adjustment for age, sex, educational level, illness duration, antidepressant, chlorpromazine equivalent dose, tobacco smoking and obesity, a negative correlation was found between hs-CRP level and the perfusion of 4 brain areas: the right inferior frontal gyrus, the right middle/superior temporal gyrus, the left superior parietal lobe and the right postcentral/transverse temporal gyrus (p-voxel < 0.001, k > 80, uncorrected). An increased perfusion of the left amygdala was found in patients with hs-CRP ≥ 3 mg/L compared to those with hs-CRP level < 3mg/L. A negative correlation was found between perfusion of the right inferior frontal gyrus and the persistence of positive, negative and excitement symptoms under antipsychotic treatment. Conclusion. In stabilized patients with schizophrenia, peripheral inflammation is associated with brain perfusion changes that are correlated with the persistence of psychotic symptomatology.
A Practical Method for Real-Time Detection of Pedicle Wall Breaching During Funneling
Authors: Zarchi Omer , Ohana Nissim , Mercado Eyal , Amitai Amir , Berestizshevsky Yuri , Sheinis Dimitri , Benharroch Daniel , Bar-On Elhanan 
Published: March 2021

Abstract
Background: A reliable, real-time method for the detection of pedicle wall breaching during funnelling in spine deformity surgery could be accessible to any surgeon assisted with neuromonitoring.Methods: Fifty-six consecutive patients (1066 pedicles), who were submitted to spinal deformity surgery from December 2013 to July 2015 were included in the study group. A control group of 13 consecutive patients (226 pedicles) with spinal deformity surgery were operated on from January to December 2013 and were excluded from finder stimulation. In the study cohort, continuous stimulation during funnelling was delivered via a finder and subsequently a compound muscle action potential (CMAP) threshold was determined. Following funnelling, manual inspection of the pedicular internal walls was performed. The CMAP thresholds were compared with the results of palpation to determine the sensitivity and specificity of the technique for detecting pedicular breaching. In order to cover common ranges of damage, the medial and lateral breaches were compared and the concave-apical breaches compared to the non-apical or convex-apical breaches. In addition, a pedicle screw test was estimated for all patients.Results: ROC analysis showed 9 mA cut-off to have a sensitivity of 88.0% and a specificity of 89.5% for predicting pedicular breaching, with an area under the curve of 0.92 (95% confidence interval, 0.90-0.94; P < .001). Using 9 mA threshold as an alert criterion, funnelling at the concave-apical pedicles showed significantly more true and false positive alerts and fewer true negative alerts when compared with the non-apical and convex-apical pedicles (P<.001). Medial breaches had significantly lower stimulation thresholds than lateral breaches (P <.001). Thresholds of screw-testing were significantly higher for study- than for control-patients (P=.002).Conclusions: Finder stimulation has a considerably higher sensitivity and specificity for prediction of pedicular breaching, most prominent for medial breaches. Screw-testing displayed significantly better results in patients undergoing the finder stimulation technique, as compared with the control group. The main advantages of our method are its high safety level and low cost, which may be critical in less affluent countries. Level of evidence III.
The Temporal Structure and Association Networks of Endophytic Bacteria in Pea Roots and Nodules
Authors: Lv Xin , Wang Qiankun , Zhang Xiaoyan , Hao Junjie , Li Li , Chen Wang , Li Haokun , Wang Yuhui , Ma Cuiping , Wang Jialin , Liu Quanlan 
Published: March 2021

Abstract
Background and aims Endophytic bacteria from legume roots and nodules play important roles in regulating plant growth and health. However, little is known about how the endophytic bacteria community changes and how it interacts with each other throughout the plant life cycle. Methods We collected twenty pea cultivars to study the composition and structure of endophytic bacterial community during the whole developmental period using Illumina sequencing of 16S rRNA gene. Results Here we show that the development period significantly affected the structure of root endophytic bacterial community and peas recruit different root microbes during different developmental stages. The complexity of microbial community first increased and then decreased with the growth of pea. Rhizobium began to accumulate in pea seedling roots, and the content peaked at flowering stage and remained at high levels during the mature stage. In the flowering and mature stage, the relative abundance of Pseudomonas increased. Conclusions These findings can deepen the overall understanding of the community structure and interaction network of endophytic bacteria from pea root and nodules, and provide a detail for the establishment of root endophytic bacteria throughout the plant life cycle.