bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rejection Sensitivity in Intimate Relationships
Authors: Richter Marianne , Schoebi Dominik 
Published: September 2021

Abstract. The goal of the study was to investigate whether and how perceptions of rejection are predictive of perceptions of the partner’s responsiveness, and the intimacy felt with a romantic partner, daily. Moreover, we examined whether people who are more anxious and sensitive to rejection perceived more rejection in daily life and whether this foreshadowed perception of the partner to be less responsive. Analyses of daily data from a sample of 75 couples ( N = 150) who reported on their daily relational experiences suggest that rejection sensitivity and rejection experiences play a significant role in couples’ felt intimacy in daily life, and specifically for perceptions of responsiveness. Results also indicate that for women, rejection sensitivity is associated with more rejection experiences. We discuss the current results from a clinical and from a social psychological perspective, and we highlight how anxious apprehension and experience of rejection, and its interpersonal consequences, can be further considered in clinical practice.
Cures That (Make You) Work
Authors: Aengenheister Jana S. , Urban Renée , Halbeisen Georg 
Published: September 2021

Abstract. Successful treatment not only depends on adhering to taking medication and attending therapy but also on behavioral changes. In two experiments (total N = 256), we investigated the hypothesis that the perceived social role of a treatment as partner (co-producer of a health-benefits) or servant (sole provider of health benefits) could promote or prevent intentions to engage in health-related behaviors. Specifically, we used headache treatment as an everyday example and found that participants were more inclined to engage in headache-reducing behaviors when painkillers were described as partners as compared to servants. Implications of these findings for the importance of anthropomorphic social perception in the clinical application are discussed.
Assessing Adaptive Irrigation Impacts on Water Scarcity in Nonstationary Environments—A Multi‐Agent Reinforcement Learning Approach
Authors: Hung Fengwei , Yang Y. C. Ethan 
Published: September 2021

AbstractOne major challenge in water resource management is to balance the uncertain and nonstationary water demands and supplies caused by the changing anthropogenic and hydroclimate conditions. To address this issue, we developed a reinforcement learning agent‐based modeling (RL‐ABM) framework where agents (agriculture water users) are able to learn and adjust water demands based on their interactions with the water systems. The intelligent agents are created by a reinforcement learning algorithm adapted from the Q‐learning algorithm. We illustrated this framework in a case study where the RL‐ABM is two‐way coupled with the Colorado River Simulation System (CRSS), a long‐term planning model used for the administration of the Colorado River Basin, for assessing agriculture water uses impacts on water scarcity. Seventy‐eight intelligent agents are simulated, which can be grouped into three categories based on their parameter values: the “aggressive” (swift actions; low regrets), the “forward‐looking conservative” (mild actions; high regrets; fast learning), and the “myopic conservative” (mild actions; median regrets; slow learning). The ABM‐CRSS results showed that the major reservoirs in the Upper Colorado Basin might experience more frequent water shortages due to the increasing water uses compared to the original CRSS results. If the drought continues, the case study also demonstrates that agents can learn and adjust their demands.
Australian Plate Subduction is Responsible for Northward Motion of the India‐Asia Collision Zone and ∼1,000 km Lateral Migration of the Indian Slab
Authors: Parsons Andrew J. , Sigloch Karin , Hosseini Kasra 
Published: September 2021

AbstractDistributions of slabs within Earth's mantle are increasingly used to reconstruct past subduction zones, based on first‐order assumptions that slabs sink vertically after slab break‐off, and thus delineate paleo‐trench locations. Non‐vertical slab motions, which occur prior to break‐off, represent a potentially significant source of error for slab‐based plate reconstructions, but are poorly understood. We constrain lateral migration of the Indian slab and overlying India‐Asia collision zone by comparing tomographically imaged mantle structure with plate‐kinematic constraints. Following coupling of the Indian and Australian plates at the onset of collision, ∼1,000 km lateral migration of the Indian slab was driven by vertical subduction of the Australian slab. The sinking behaviors of individual slabs do not evolve in isolation, but instead influence, or are influenced by, other slabs in the same plate network. Hence, lateral slab migrations may be determined by interpreting the sinking behavior of slabs collectively, and with respect to plate kinematics.
Adjoint‐Based Inversion of Geodetic Data for Sources of Deformation and Strain
Authors: Smith J. Torquil , Vasco D. W. 
Published: September 2021

AbstractAn adjoint‐based formulation leads to a particularly efficient approach for inverting geodetic measurements for the source of the deformation. Specifically, the quantities necessary to iteratively improve the fit to the observations can be computed with just three forward calculations, one to obtain the current residuals, another to solve the adjoint problem, and a third to compute the step length. An inversion algorithm utilizing the adjoint‐based gradient is applied to a set of Interferometric Synthetic Aperture Radar (InSAR) data gathered between 2016 and 2018 over the Tulare Basin in California's Central Valley. Because the measured deformation is due to groundwater withdrawal, a penalty function is included in the inversion to avoid placing aquifer volume change in locations that are far from any documented wells. The solution of the inverse problem provides estimates of aquifer compaction that provide a match to the observed range changes while honoring the well data. The solution indicates an average aquifer volume loss of 2.17 /year over the two year period from January 2016 to January 2018, encompassing one drought year (2016) and one wet year (2017). This magnitude of lost volume is compatible with the 3.1 /year decrease in water volume for the entire Central Valley, estimated from GRACE satellite gravity data.
Electrostatic Conditions That Produce Fast Breakdown in Thunderstorms
Authors: Attanasio Alex , da Silva Caitano , Krehbiel Paul 
Published: September 2021

AbstractFast breakdown (FB), a breakdown process composed of systems of high‐velocity streamers, has been observed to precede lightning leader formation and play a critical role in lightning initiation. Vigorous FB events are responsible for the most powerful natural radio emissions on Earth, known as narrow bipolar events (NBEs). In this paper, an improved version of the Griffiths and Phelps (1976, https://doi.org/10.1029/jc081i021p03671) model of streamer breakdown is used alongside supervised machine learning techniques to probe the required electric fields and potentials inside thunderstorms to produce FB and NBEs. Our results show that the electrostatic conditions needed to produce FB observed in New Mexico at 9 km altitude and FB in Florida at 14 km altitude are about the same, each requiring about 100 MV potential difference to propagate 500 m. Additionally, the model illustrates how electric field enhancement ahead of propagating FB can initiate rebounding FB of the opposite polarity.
The self-assembled nanoparticle-based trimeric RBD mRNA vaccine elicits robust and durable protective immunity against SARS-CoV-2 in mice
Authors: Sun Wenqiang , He Lihong , Zhang He , Tian Xiaodong , Bai Zhihua , Sun Lei , Yang Limin , Jia Xiaojuan , Bi Yuhai , Luo Tingrong , Cheng Gong , Fan Wenhui , Liu Wenjun , Li Jing 
Published: September 2021

AbstractAs COVID-19 continues to spread rapidly worldwide and variants continue to emerge, the development and deployment of safe and effective vaccines are urgently needed. Here, we developed an mRNA vaccine based on the trimeric receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein fused to ferritin-formed nanoparticles (TF-RBD). Compared to the trimeric form of the RBD mRNA vaccine (T-RBD), TF-RBD delivered intramuscularly elicited robust and durable humoral immunity as well as a Th1-biased cellular response. After further challenge with live SARS-CoV-2, immunization with a two-shot low-dose regimen of TF-RBD provided adequate protection in hACE2-transduced mice. In addition, the mRNA template of TF-RBD was easily and quickly engineered into a variant vaccine to address SARS-CoV-2 mutations. The TF-RBD multivalent vaccine produced broad-spectrum neutralizing antibodies against Alpha (B.1.1.7) and Beta (B.1.351) variants. This mRNA vaccine based on the encoded self-assembled nanoparticle-based trimer RBD provides a reference for the design of mRNA vaccines targeting SARS-CoV-2.
Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits
Authors: Tierney Elaine , Remaley Alan T. , Thurm Audrey , Jager Leah R. , Wassif Christopher A. , Kratz Lisa E. , Bailey-Wilson Joan E. , Bukelis Irena , Sarphare Geeta , Jung Eun Sol , Brand Boudewien , Noah Kelly K. , Porter Forbes D. 
Published: September 2021

AbstractAn improved understanding of sterol and lipid abnormalities in individuals with autism spectrum disorder (ASD) could lead to personalized treatment approaches. Toward this end, in blood, we identified reduced synthesis of cholesterol in families with ≥2 children with ASD participating with the Autism Genetic Resource Exchange (AGRE), as well as reduced amounts of high-density lipoprotein cholesterol (HDL), apolipoprotein A1 (ApoA1) and apolipoprotein B (ApoB), with 19.9% of the subjects presenting with apolipoprotein patterns similar to hypolipidemic clinical syndromes and 30% with either or both ApoA1 and ApoB less than the fifth centile. Subjects with levels less than the fifth centile of HDL or ApoA1 or ApoA1 + ApoB had lower adaptive functioning than other individuals with ASD, and hypocholesterolemic subjects had apolipoprotein deficits significantly divergent from either typically developing individuals participating in National Institutes of Health or the National Health and Nutrition Examination Survey III.
High harmonic generation in two-dimensional Mott insulators
Authors: Orthodoxou Christopher , Zaïr Amelle , Booth George H. 
Published: September 2021

AbstractWith a combination of numerical methods, including quantum Monte Carlo, exact diagonalization, and a simplified dynamical mean-field model, we consider the attosecond charge dynamics of electrons induced by strong-field laser pulses in two-dimensional Mott insulators. The necessity to go beyond single-particle approaches in these strongly correlated systems has made the simulation of two-dimensional extended materials challenging, and we contrast their resulting high-harmonic emission with more widely studied one-dimensional analogues. As well as considering the photo-induced breakdown of the Mott insulating state and magnetic order, we also resolve the time and ultra-high-frequency domains of emission, which are used to characterize both the photo-transition, and the sub-cycle structure of the electron dynamics. This extends simulation capabilities and understanding of the photo-melting of these Mott insulators in two dimensions, at the frontier of attosecond non-equilibrium science of correlated materials.
Oral intake of rice overexpressing ubiquitin ligase inhibitory pentapeptide prevents atrophy in denervated skeletal muscle
Authors: Nakao Reiko , Shen Weilin , Shimajiri Yasuka , Kainou Kumiko , Sato Yuki , Ulla Anayt , Ohnishi Kohta , Ninomiya Miyuki , Ohno Ayako , Uchida Takayuki , Tanaka Mitsuru , Akama Kazuhito , Matsui Toshiro , Nikawa Takeshi 
Published: September 2021

AbstractWe previously reported that intramuscular injections of ubiquitin ligase CBLB inhibitory pentapeptide (Cblin; Asp-Gly-pTyr-Met-Pro) restored lost muscle mass caused by sciatic denervation. Here, we detected Cblin on the basolateral side of Caco-2 cells after being placed on the apical side, and found that cytochalasin D, a tight junction opener, enhanced Cblin transport. Orally administered Cblin was found in rat plasma, indicating that intact Cblin was absorbed in vitro and in vivo. Furthermore, transgenic Cblin peptide-enriched rice (CbR) prevented the denervation-induced loss of muscle mass and the upregulation of muscle atrophy-related ubiquitin ligases in mice. These findings indicated that CbR could serve as an alternative treatment for muscle atrophy.
Chemogenetic modulation of histaminergic neurons in the tuberomamillary nucleus alters territorial aggression and wakefulness
Authors: Naganuma Fumito , Nakamura Tadaho , Kuroyanagi Hiroshi , Tanaka Masato , Yoshikawa Takeo , Yanai Kazuhiko , Okamura Nobuyuki 
Published: September 2021

AbstractDesigner receptor activated by designer drugs (DREADDs) techniques are widely used to modulate the activities of specific neuronal populations during behavioural tasks. However, DREADDs-induced modulation of histaminergic neurons in the tuberomamillary nucleus (HATMN neurons) has produced inconsistent effects on the sleep–wake cycle, possibly due to the use of Hdc-Cre mice driving Cre recombinase and DREADDs activity outside the targeted region. Moreover, previous DREADDs studies have not examined locomotor activity and aggressive behaviours, which are also regulated by brain histamine levels. In the present study, we investigated the effects of HATMN activation and inhibition on the locomotor activity, aggressive behaviours and sleep–wake cycle of Hdc-Cre mice with minimal non-target expression of Cre-recombinase. Chemoactivation of HATMN moderately enhanced locomotor activity in a novel open field. Activation of HATMN neurons significantly enhanced aggressive behaviour in the resident–intruder test. Wakefulness was increased and non-rapid eye movement (NREM) sleep decreased for an hour by HATMN chemoactivation. Conversely HATMN chemoinhibition decreased wakefulness and increased NREM sleep for 6 h. These changes in wakefulness induced by HATMN modulation were related to the maintenance of vigilance state. These results indicate the influences of HATMN neurons on exploratory activity, territorial aggression, and wake maintenance.
Automatic detection and monitoring of abnormal skull shape in children with deformational plagiocephaly using deep learning
Authors: Tabatabaei Seyed Amir Hossein , Fischer Patrick , Wattendorf Sonja , Sabouripour Fatemeh , Howaldt Hans-Peter , Wilbrand Martina , Wilbrand Jan-Falco , Sohrabi Keywan 
Published: September 2021

AbstractCraniofacial anomaly including deformational plagiocephaly as a result of deformities in head and facial bones evolution is a serious health problem in newbies. The impact of such condition on the affected infants is profound from both medical and social viewpoint. Indeed, timely diagnosing through different medical examinations like anthropometric measurements of the skull or even Computer Tomography (CT) image modality followed by a periodical screening and monitoring plays a vital role in treatment phase. In this paper, a classification model for detecting and monitoring deformational plagiocephaly in affected infants is presented. The presented model is based on a deep learning network architecture. The given model achieves high accuracy of 99.01% with other classification parameters. The input to the model are the images captured by commonly used smartphone cameras which waives the requirement to sophisticated medical imaging modalities. The method is deployed into a mobile application which enables the parents/caregivers and non-clinical experts to monitor and report the treatment progress at home.
Hemicentin-1 is an essential extracellular matrix component of the dermal–epidermal and myotendinous junctions
Authors: Welcker Daniela , Stein Cornelia , Feitosa Natalia Martins , Armistead Joy , Zhang Jin-Li , Lütke Steffen , Kleinridders Andre , Brüning Jens C. , Eming Sabine A. , Sengle Gerhard , Niehoff Anja , Bloch Wilhelm , Hammerschmidt Matthias 
Published: September 2021

AbstractThe extracellular matrix architecture is composed of supramolecular fibrillar networks that define tissue specific cellular microenvironments. Hemicentins (Hmcn1 and Hmcn2) are ancient and very large members (> 600 kDa) of the fibulin family, whose short members are known to guide proper morphology and functional behavior of specialized cell types predominantly in elastic tissues. However, the tissue distribution and function of Hemicentins within the cellular microenvironment of connective tissues has remained largely unknown. Performing in situ hybridization and immunofluorescence analyses, we found that mouse Hmcn1 and Hmcn2 show a complementary distribution throughout different tissues and developmental stages. In postnatal dermal–epidermal junctions (DEJ) and myotendinous junctions (MTJ), Hmcn1 is primarily produced by mesenchymal cells (fibroblasts, tenocytes), Hmcn2 by cells of epithelial origin (keratinocytes, myocytes). Hmcn1−/− mice are viable and show no overt phenotypes in tissue tensile strength and locomotion tests. However, transmission electron microscopy revealed ultrastructural basement membrane (BM) alterations at the DEJ and MTJ of Hmcn1−/− mice, pointing to a thus far unknown role of Hmcn1 for BM and connective tissue boundary integrity.
Spacetime in the brain: rapid brain network reorganization in visual processing and recovery
Authors: Wu Zheng , Sabel Bernhard A. 
Published: September 2021

AbstractFunctional connectivity networks (FCN) are the physiological basis of brain synchronization to integrating neural activity. They are not rigid but can reorganize under pathological conditions or during mental or behavioral states. However, because mental acts can be very fast, like the blink of an eye, we now used the visual system as a model to explore rapid FCN reorganization and its functional impact in normal, abnormal and post treatment vision. EEG-recordings were time-locked to visual stimulus presentation; graph analysis of neurophysiological oscillations were used to characterize millisecond FCN dynamics in healthy subjects and in patients with optic nerve damage before and after neuromodulation with alternating currents stimulation and were correlated with visual performance. We showed that rapid and transient FCN synchronization patterns in humans can evolve and dissolve in millisecond speed during visual processing. This rapid FCN reorganization is functionally relevant because disruption and recovery after treatment in optic nerve patients correlated with impaired and recovered visual performance, respectively. Because FCN hub and node interactions can evolve and dissolve in millisecond speed to manage spatial and temporal neural synchronization during visual processing and recovery, we propose “Brain Spacetime” as a fundamental principle of the human mind not only in visual cognition but also in vision restoration.
Wood ants as biological control of the forest pest beetles Ips spp.
Authors: Trigos-Peral Gema , Juhász Orsolya , Kiss Péter János , Módra Gábor , Tenyér Anna , Maák István 
Published: September 2021

AbstractClimate change is one of the major threats to biodiversity, but its impact varies among the species. Bark beetles (Ipsspp.), as well as other wood-boring pests of European forests, show escalating numbers in response to the changes driven by climate change and seriously affect the survival of the forests through the massive killing of trees. Many methods were developed to control these wood-boring beetles, however, their implementation can be detrimental for other forest specialists. Ants are widely used for biological pest-control, so in our study, we aimed to test the effect ofFormica polyctenaon the control of the wood-boring beetles. The results show that the proportion of infested trees is significantly reduced by the increase of the number ofF. polyctenanests, with a strong effect on those infested by Ipsspecies. We also show that the boring beetle community is shaped by different biotic and abiotic factors, including the presence ofF. polyctenanests. However, the boring beetle infestation was not related to the latitude, altitude and age of the forests. Based on our results, we assert the effectiveness of the red wood ants as biological pest control and the importance of their conservation to keep the health of the forests.
Characterisation of lamina I anterolateral system neurons that express Cre in a Phox2a-Cre mouse line
Authors: Alsulaiman Wafa A. A. , Quillet Raphaelle , Bell Andrew M. , Dickie Allen C. , Polgár Erika , Boyle Kieran A. , Watanabe Masahiko , Roome R. Brian , Kania Artur , Todd Andrew J. , Gutierrez-Mecinas Maria 
Published: September 2021

AbstractA recently developed Phox2a::Cre mouse line has been shown to capture anterolateral system (ALS) projection neurons. Here, we used this line to test whether Phox2a-positive cells represent a distinct subpopulation among lamina I ALS neurons. We show that virtually all lamina I Phox2a cells can be retrogradely labelled from injections targeted on the lateral parabrachial area (LPb), and that most of those in the cervical cord also belong to the spinothalamic tract. Phox2a cells accounted for ~ 50–60% of the lamina I cells retrogradely labelled from LPb or thalamus. Phox2a was preferentially associated with smaller ALS neurons, and with those showing relatively weak neurokinin 1 receptor expression. The Phox2a cells were also less likely to project to the ipsilateral LPb. Although most Phox2a cells phosphorylated extracellular signal-regulated kinases following noxious heat stimulation, ~ 20% did not, and these were significantly smaller than the activated cells. This suggests that those ALS neurons that respond selectively to skin cooling, which have small cell bodies, may be included among the Phox2a population. Previous studies have defined neurochemical populations among the ALS cells, based on expression of Tac1 or Gpr83. However, we found that the proportions of Phox2a cells that expressed these genes were similar to the proportions reported for all lamina I ALS neurons, suggesting that Phox2a is not differentially expressed among cells belonging to these populations. Finally, we used a mouse line that resulted in membrane labelling of the Phox2a cells and showed that they all possess dendritic spines, although at a relatively low density. However, the distribution of the postsynaptic protein Homer revealed that dendritic spines accounted for a minority of the excitatory synapses on these cells. Our results confirm that Phox2a-positive cells in lamina I are ALS neurons, but show that the Phox2a::Cre line preferentially captures specific types of ALS cells.
Smart-cut-like laser slicing of GaN substrate using its own nitrogen
Authors: Tanaka Atsushi , Sugiura Ryuji , Kawaguchi Daisuke , Yui Toshiki , Wani Yotaro , Aratani Tomomi , Watanabe Hirotaka , Sena Hadi , Honda Yoshio , Igasaki Yasunori , Amano Hiroshi 
Published: September 2021

AbstractWe have investigated the possibility of applying lasers to slice GaN substrates. Using a sub-nanosecond laser with a wavelength of 532 nm, we succeeded in slicing GaN substrates. In the laser slicing method used in this study, there was almost no kerf loss, and the thickness of the layer damaged by laser slicing was about 40 µm. We demonstrated that a standard high quality homoepitaxial layer can be grown on the sliced surface after removing the damaged layer by polishing.