bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimating Caprock Impact on CO2 Migration in the Gassum Formation Using 2D Seismic Line Data
Authors: Andersen Odd , Sundal Anja 
Published: May 2021

AbstractRealizable CO2 storage potential for saline formations without closed lateral boundaries depends on the combined effects of physical and chemical trapping mechanisms to prevent long-term migration out of the defined storage area. One such mechanism is the topography of the caprock surface, which may retain CO2 in structural pockets along the migration path. Past theoretical and modeling studies suggest that even traps too small to be accurately described by seismic data may play a significant role. In this study, we use real but scarce seismic data from the Gassum Formation of the Norwegian Continental shelf to estimate the impact of topographical features of the top seal in limiting CO2 migration. We seek to estimate the amount of macro- and sub-scale trapping potential of the formation based on a few dozen interpreted 2D seismic lines and identified faults. We generate multiple high-resolution realizations of the top surface, constructed to be faithful to both large-scale topography and small-scale statistical properties. The structural trapping and plume retardation potential of these top surfaces is subsequently estimated using spill-point (static) analysis and dynamical flow simulation. By applying these techniques on a large ensemble of top surface realizations generated using a combination of stochastic realizations and systematic variation of key model parameters, we explore the range of possible impacts on plume advancement, physical trapping and migration direction. The stochastic analysis of trapping capacity and retardation efficiency in statistically generated, sub-seismic resolution features may also be applied for surfaces generated from 3D data.
Internalizing the externalities of overfunding: an agent-based model approach for analyzing the market dynamics on crowdfunding platforms
Authors: Koch Jascha-Alexander , Lausen Jens , Kohlhase Moritz 
Published: May 2021

AbstractCrowdfunding platforms offer project initiators the opportunity to acquire funds from the Internet crowd and, therefore, have become a valuable alternative to traditional sources of funding. However, some processes on crowdfunding platforms cause undesirable external effects that influence the funding success of projects. In this context, we focus on the phenomenon of project overfunding. Massively overfunded projects have been discussed to overshadow other crowdfunding projects which in turn receive less funding. We propose a funding redistribution mechanism to internalize these overfunding externalities and to improve overall funding results. To evaluate this concept, we develop and deploy an agent-based model (ABM). This ABM is based on a multi-attribute decision-making approach and is suitable to simulate the dynamic funding processes on a crowdfunding platform. Our evaluation provides evidence that possible modifications of the crowdfunding mechanisms bear the chance to optimize funding results and to alleviate existing flaws.
Nationalpopulismus und Faschismus im historischen Vergleich. Zur Aktualität von Max Webers Herrschaftssoziologie
Authors: Bach Maurizio 
Published: May 2021

ZusammenfassungDer Aufstieg des Rechtspopulismus im vergangenen Jahrzehnt, aber auch jüngst die „autoritär“ anmutenden staatlichen Maßnahmen zur Bekämpfung der Corona-Pandemie haben in verschiedenen politischen Lagern verstärkt Vergleiche mit dem historischen Faschismus evoziert. In dem Beitrag steht die Frage im Mittelpunkt, inwieweit ein solcher diachroner Vergleich empirisch belastbar und damit aussagekräftig ist. Methodisch orientiert sich die Argumentation an Max Webers Konzept des Idealtypus, der als tertium comparationis angewendet werden kann. Mit dem „faschistischen Minimum“, einem soziologischen Begriffskonstrukt, das generelle Strukturmerkmale faschistischer Bewegungen und Regime bündelt, steht ein theoretisch tragfähiger und empirisch gehaltvoller Vergleichsmaßstab zur Verfügung. Unter den analytischen Gesichtspunkten des „faschistischen Minimums“ prüft der Artikel, ob und gegebenenfalls in welchem Maße gegenwärtige Tendenzen der Politik und des Staates in Deutschland „faschistische“ Züge aufweisen.
Detoxification of the tricyclic antidepressant opipramol and its analog – IS-noh by UGT enzymes before and after activation by phase I enzymes in rat liver microsomes
Authors: Mieszkowska Anna , Hemine Koleta , Skwierawska Anna , Augustin Ewa , Mazerska Zofia 
Published: May 2021

AbstractThe present studies were carried out to evaluate the simultaneous one-pot metabolism of opipramol (IS-opi) and analog (IS-noh) by phase I and phase II enzymes present in rat liver microsomes (RLM) as an alternative to separate testing with recombinant enzymes. This approach allows for more time-saving and cost-effective screening of the metabolism of newly discovered drugs. We also considered that the lack of results for phase II, including UGT, often creates problems in correct selection of valuable compounds. Moreover, microsomes data set is richer in the contest and provides medical scientist to determine also the susceptibility of drugs to undergo phase I and then phase II. In the present work, we have shown that IS-noh was metabolized in vitro by phase I enzymes to the oxidation product, which was next transformed with UGTs to glucuronide. The results showed also that the previously known oxidation product of opipramol was changed to previously no reported glucuronidation product by UDP-glucuronosyltransferases. In addition, unlike IS-noh, opipramol did not prove to be the substrate for UGTs. Therefore, tricyclic antidepressants depending on the structure can trigger a different response after contact with UGT enzymes. Some will metabolize directly with UGTs, others only after activation by phase I enzymes.
Negative updating applied to the best-of-n problem with noisy qualities
Authors: Lee Chanelle , Lawry Jonathan , Winfield Alan F. T. 
Published: May 2021

AbstractThe ability to perform well in the presence of noise is an important consideration when evaluating the effectiveness of a collective decision-making framework. Any system deployed for real-world applications will have to perform well in complex and uncertain environments, and a component of this is the limited reliability and accuracy of evidence sources. In particular, in swarm robotics there is an emphasis on small and inexpensive robots which are often equipped with low-cost sensors more prone to suffer from noisy readings. This paper presents an exploratory investigation into the robustness of a negative updating approach to the best-of-n problem which utilises negative feedback from direct pairwise comparison of options and opinion pooling. A site selection task is conducted with a small-scale swarm of five e-puck robots choosing between $$n=7$$

n
=
7

options in a semi-virtual environment with varying levels of sensor noise. Simulation experiments are then used to investigate the scalability of the approach. We now vary the swarm size and observe the behaviour as the number of options n increases for different error levels with different pooling regimes. Preliminary results suggest that the approach is robust to noise in the form of noisy sensor readings for even small populations by supporting self-correction within the population.
Hypertrophic Cardiomyopathy: Updates Through the Lens of Sports Cardiology
Authors: Lander Bradley S. , Phelan Dermot M. , Martinez Matthew W. , Dineen Elizabeth H. 
Published: May 2021

Abstract
Purpose of review
This review will summarize the distinction between hypertrophic cardiomyopathy (HCM) and exercise-induced cardiac remodeling (EICR), describe treatments of particular relevance to athletes with HCM, and highlight the evolution of recommendations for exercise and competitive sport participation relevant to individuals with HCM.

Recent findings
Whereas prior guidelines have excluded individuals with HCM from more than mild-intensity exercise, recent data show that moderate-intensity exercise improves functional capacity and indices of cardiac function and continuation of competitive sports may not be associated with worse outcomes. Moreover, recent studies of athletes with implantable cardioverter defibrillators (ICDs) demonstrated a safer profile than previously understood. In this context, the updated American Heart Association/American College of Cardiology (AHA/ACC) and European Society of Cardiology (ESC) HCM guidelines have increased focus on shared decision-making and liberalized restrictions on exercise and sport participation among individuals with HCM.

Summary
New data demonstrating the safety of exercise in individuals with HCM and in athletes with ICDs, in addition to a focus on shared decision-making, have led to the most updated guidelines easing restrictions on exercise and competitive athletics in this population. Further athlete-specific studies of HCM, especially in the context of emerging therapies such as mavacamten, are important to inform accurate risk stratification and eligibility recommendations.
Endocrine-related adverse events in a large series of cancer patients treated with anti-PD1 therapy
Authors: Rubino Rossella , Marini Andrea , Roviello Giandomenico , Presotto Elena Margherita , Desideri Isacco , Ciardetti Isabella , Brugia Marco , Pimpinelli Nicola , Antonuzzo Lorenzo , Mini Enrico , Livi Lorenzo , Maggi Mario , Peri Alessandro 
Published: May 2021

Abstract
Purpose
Immune checkpoint inhibitors have opened a new scenario in the treatment of cancer. These agents can elicit adverse events, which may affect different systems and organs, including the endocrine system. The aims of this study were to evaluate the impact of the anti-PD-1 molecules nivolumab and pembrolizumab on endocrine toxicity and on patient outcome.

Methods
A retrospective and multicentre study was designed, which involved a total of 251 patients affected by different tumors (mostly non-small cell lung cancer, 68.92% and melanoma, 24.30%) and treated with the PD-1 inhibitors nivolumab (61.35%) or pembrolizumab (38.65%) for up to 60 months. Clinical and biochemical data were recorded until July 31, 2020.

Results
Endocrine toxicity occurred in 70 out of 251 patients (27.89%). It was mostly related to thyroid dysfunction and in 75% of cases occurred within 6 months from the beginning of therapy. A previous endocrine morbidity and female gender were predictors of endocrine toxicity. There was no association between endocrine dysfunction and patient outcome. However, when all toxicities (i.e., endocrine and non endocrine) were considered, a significant association with progression-free survival and overall survival was found.

Conclusions
Thyroid alterations are frequently observed in cancer patients treated with anti PD-1 drugs, particularly in women and in the presence of a previous endocrinopathy. We suggest that regular thyroid assessment should be performed in these patients, especially in the first months of therapy. Finally, the onset of side effects, related to anti PD-1 agents, appears to be associated with a better outcome.
Clinical presentation, genotype–phenotype correlations, and outcome of pancreatic neuroendocrine tumors in Von Hippel–Lindau syndrome
Authors: Penitenti F. , Landoni L. , Scardoni M. , Piredda M. L. , Cingarlini S. , Scarpa A. , D’Onofrio M. , Girelli D. , Davi M. V. 
Published: May 2021

Abstract
Purpose
Data regarding the clinical management and follow-up of pancreatic neuroendocrine tumors (PanNETs) associated with Von Hippel–Lindau (VHL) syndrome are limited. This study aimed to assess clinical presentation, genotype–phenotype correlations, treatment and prognosis of PanNETs in a series of VHL syndrome patients.

Methods
Retrospective analysis of data of patients observed between 2005 and 2020.

Results
Seventeen patients, including 12 probands and 5 relatives (mean age 30.8 ± 18.4; 7 males), were recruited. PanNETs were found in 13/17 patients (77.5%) at a median age of 37 years: 4/13 (30.7%) at the time of VHL diagnosis and 9 (69.3%) during follow up. Six (46.1%) PanNET patients underwent surgery, whereas seven were conservatively treated (mean tumor diameter: 40 ± 10.9 vs. 15 ± 5.3 mm respectively). Four patients (30.7%) had lymph node metastases and a mean tumor diameter significantly larger than the nonmetastatic PanNETs (44.2 ± 9.3 vs. 17.4 ± 7 mm, p = 0.00049, respectively). Five (83.3%) operated patients had stable disease after a median follow up of 3 years whereas one patient showed liver metastases. Six (85.7%) non-resected PanNETs were stable after a median follow-up of 2 years, whereas one patient developed a new small PanNET and a slight increase in diameter of a pre-existing PanNET. No correlation was found between the type of germline mutation and malignant behavior of PanNETs.

Conclusions
PanNETs are a common disease of the VHL syndrome and can be the presenting feature. Tumor size rather than genetic mutation is a prognostic factor of malignancy.
The International Development of Open Access Publishing: A Comparative Empirical Analysis Over Seven World Regions and Nine Academic Disciplines
Authors: Demeter Marton , Jele Agnes , Major Zsolt Balázs 
Published: May 2021

AbstractThis paper offers a cross-country and cross-disciplinary analysis of the development of open access publishing from 2000 to 2019. Through an analysis of seven world regions and nine scholarly fields, we found that, while the overall share of open access journals has increased significantly over the last two decades, there are important differences across both the analyzed world regions and disciplines. We also found that, with the exception of neuroscience, the proportion of open access journals is considerably lower among the journals ranked in the Q1 quartile of Scopus than in the general field. We also offer a model that explains the development of open access publishing trends on different disciplinary and geographical levels.
When it really counts: Investigating the relation between trait mindfulness and actual prosocial behavior
Authors: Schindler Simon , Pfattheicher Stefan 
Published: May 2021

AbstractMeta-analytical findings suggested a positive link between trait mindfulness and prosociality. However, most correlational studies on mindfulness and prosociality have relied on self-report measures. The present work aimed to address this serious limitation by investigating actual prosocial behavior. We further focused on mindfulness as a multi-dimensional personality trait to disentangle effects of different mindfulness aspects. In addition, we tested whether the relation between trait mindfulness and prosocial behavior emerges under a theoretical meaningful experimental boundary condition (i.e., feelings of guilt). In two studies (using four different samples; N = 1240), we did not find support for a positive link between trait mindfulness and (a) charitable donation and (b) behavior in an incentivized economic game, respectively. Evidence for manipulated guilt-level as a moderator was inconclusive. Taken together, the findings point to a more complex role of trait mindfulness for prosocial behavior. Limitations and ideas for further research are discussed.
Clinical Presentation of Varicose Veins
Authors: Ghosh Shantonu Kumar , Al Mamun Abdullah , Majumder Alpana 
Published: May 2021

AbstractVaricose vein is one type of venous insufficiency that presents with any dilated, elongated, or tortuous veins caused by permanent loss of its valvular efficiency. Destruction of venous valves in the axial veins results in venous hypertension, reflux, and total dilatation, causing varicosities and transudation of fluid into subcutaneous tissue. The first documented reference of varicose veins was found as illustrations on Ebers Papyrus dated 1550 B.C. in Athens. Evidence of surgical intervention was found in the 1860s. However dramatic advances of varicose vein management occurred in the latter half of twentieth century. Varicose veins affect from 40 to 60% of women and 15 to 30% men. Multiple intrinsic and extrinsic factors including age, gender, pregnancy, weight, height, race, diet, bowel habits, occupation, posture, previous DVT, genetics, and climate are considered to be the predisposing factors for formation of varicose vein. Other reported factors are hereditary, standing occupation, chair sitting, tight underclothes, raised toilet seats, lack of exercise, smoking, and oral contraceptives. Common symptoms are unsightly visible veins, pain, aching, swelling, itching, skin changes, ulceration, thrombophlebitis, and bleeding. The signs of varicose vein disease are edema, varicose eczema or thrombophlebitis, ulcers (typically found over the medial malleolus), hemosiderin skin staining, lipodermatosclerosis (tapering of legs above ankles, an “inverted champagne bottle” appearance), and atrophie blanche. Varicose vein is classified according to CEAP classification, the components of which are clinical, etiological, anatomy, and pathophysiology. The revised CEAP classification was published on 2020 based on four principles which were preservation of the reproducibility of CEAP, compatibility with prior versions, evidence-based medicine, and practicality.
The Italian contribution to the construction of the linac for the European spallation source
Authors: Gammino S. , Fabris A. , Lindroos M. 
Published: May 2021

AbstractThe European spallation source (ESS) uses a linear accelerator (linac) to deliver the high intensity proton beam to the target station for producing intense beams of neutrons. At the exit of the linac, the proton beam will have 2 GeV energy and 62.5 mA current. The construction of an accelerator with the contribution of different laboratories is not a new concept but so far the laboratories were controlled by the same government (e.g. in USA and Japan) or they delivered components for an intergovernmental institution like CERN. The European Spallation Source is a research facility that gathers 40 active in-kind (IK) contributors from 13 States, even outside the European Union, so its construction is not only a technical and scientific challenge, but also an economic, political and social experiment. The case of the Italian contribution is interesting because of the structure of Italian industrial ecosystem, mostly based on small and medium-sized enterprises (SME), which may be unsuitable for the case of a research infrastructure which construction requires a high level of R&D investments. Conversely, the well-known flexibility of SME to adapt to the requirements have balanced the weakness and the results are satisfactory. Following the overview of the Linac design, the paper will focus on the key issues of the Italian contribution, the state of the project (73% completion up to now) along with the point of view of the ESS management and the lesson learnt; the major outcomes for the economy and society will complete the discussion.
Study of quality markers of antiuric acid formula by grey relational analysis
Authors: Wang Fang , Cao Jing , Li Yang , Ren Fugang , Bai Jing , Dong Qiang , Guo Jinlin 
Published: May 2021

AbstractGout has become a global problem, antiuric acid formula (AAF) is a clinical prescription highly effective in reducing uric acid levels. In order to find its quality control standards and contribute to the treatment of gout in the future, we adopted high-performance liquid chromatography and orbitrap liquid chromatography–mass spectrometry to establish fingerprints of 13 batches of AAF. The different batches of AAF were tested the activity of inhibit uric acid by the xanthine oxidase inhibition experiment. Grey relational analysis and bio-activity validation to assess the spectrum–effect relationship. Finally, we choose puerarin, calycosin-7-O-beta-d-glucoside and puerarin apioside as the AAF quality control component, and its average content is 6036.006 μg/g, 296.113 μg/g and 878.285 μg/g. As the quality control components of AAF, puerarin, calycosin-7-O-beta-d-glucoside and puerarin apioside can be of great significance for the treatment of gout and gout related research.
Recruitment and disengagement: two sides of the same coin or different phenomena?
Authors: Santos Nascimento Jamile , Klandermans Bert , de Theije Marjo 
Published: May 2021

AbstractWe investigate the disengagement of four former activists of the Landless Rural Workers Movement (Movimento dos Trabalhadores Rurais Sem Terra—MST) in Brazil. The MST is the largest Brazilian social movement and has mobilized activists for over 30 years. The trajectories of recruitment, participation and disengagement of its activists serve as emblematic cases for the study of disengagement in social movements in general. This research contributes to the understanding of the activists’ disengagement from a social movement, a phenomenon that has been little studied. It sheds new light on the study of disengagement in two ways. First, some characteristics of the MST, in particular that many activists live in tight-knit communities, children participation and the activists’ long-lasting participation, open up new possibilities for the analysis of factors that influence disengagement pointed out in previous studies. In addition, the analysis of former activists’ whole trajectories of recruitment-participation-disengagement allows us show that considering disengagement as the analogous process as recruitment cannot explain all of its aspects. Given that the reasons that make someone leave a movement are, not always, the same that made someone join it. A multiple-case study design was used. The semi-structured interviews encompassing the engagement trajectories of the former activists served very well to the purpose of evidencing the multi-level character of the disengagement decision-making. Our analysis reveals how the social context, the movement and the activists’ personal characteristics in conjunction play a pivotal role.
‘I was altogether out of tune with my colleagues’: Conor Cruise O'Brien and Northern Ireland, 1969–77
Authors: Kelly Stephen 
Published: May 2021

AbstractThis article critically re-assesses Conor Cruise O'Brien's attitude to Northern Ireland between 1969 and 1977. It argues that O'Brien's most significant contribution to public life was the ability to deconstruct many aspects of Irish nationalism, specifically his rejection of the Irish state's irredentist claim over Northern Ireland. In doing so, it contends that O'Brien was one of the most important, and outspoken, champions of so-called ‘revisionist nationalism’ of his generation. The article examines three themes in relation to O'Brien's attitude to Northern Ireland: his attack on the Irish state's anti-partitionism; his rejection of Irish republican terrorism; and his support for the ‘principle of consent’ argument. The article illustrates that O'Brien was criticised in nationalist circles and accused of committing political heresy. Indeed, his willingness to challenge the attitude of most mainstream Irish politicians on Northern Ireland invariably left him an isolated figure, even among his own Labour Party comrades. Writing in his Memoir, O'Brien neatly summed up the difficult position in which he found himself: ‘I was altogether out of tune with my colleagues over Northern Ireland’.