bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dimensionless Solutions for the Time-Dependent and Rate-Dependent Productivity Index of Wells in Deformable Reservoirs
Authors: Zhang Wei , Mehrabian Amin 
Published: May 2021

SummaryReservoir depletion is known to reduce the porosity and permeability of stress-sensitive reservoir rocks. The effect may substantially hinder the productivity index (PI) of producing wells. This study presents analytical solutions for the time-dependent and steady-state well PIs, respectively, of a bounded, disk-shaped, elastic reservoir with no-flow and constant-pressure conditions at the outer boundary. A combination of Green's functions, the Laplace transform method, and the perturbation technique is used to solve the governing nonlinear partial differential equations of the considered coupled problems of flow and geomechanics. Dimensional analyses based on the Buckingham Π theorem are conducted to identify the dimensionless parameters groups of each problem and to express the resulting analytical solutions in the dimensionless form. In addition, necessary corrections to an existing error in the reported Green's functions for the induced strain field of a ring-shaped pressure source within an elastic half-space (Segall 1992) are made. The corrected Green's functions are used to obtain the strain induced by the pore fluid pressure distribution within a depleting disked-shaped reservoir. Consequently, a corrected permeability variation model compared to our previously published, time-independent solution for rate-dependent PI (Zhang and Mehrabian 2021a) is presented. Finally, a mechanistically rigorous formulation of the permeability modulus parameter that commonly appears in the pertinent literature is suggested. In addition to the in-house developed finite-difference solutions, the presented analytical solutions are verified against results from the finite-element simulation of the same problems using COMSOL® Multiphysics (2018).The obtained rate-dependent PI of the reservoir is controlled by four dimensionless parameters, namely, the dimensionless rock bulk modulus, the Biot-Willis effective stress coefficient, Poisson's ratio, and rock initial porosity. The pore fluid pressure solution is shown to asymptotically approach the corresponding flow-only solution for large values of the dimensionless rock bulk modulus. Parametric analysis of the solution suggests that the well productivity loss has a reverse relationship with the dimensionless bulk modulus and initial porosity of the rock, whereas a direct relationship is identified with Biot-Willis effective stress coefficient and Poisson's ratio. Compared to the reservoir with a constant-pressure outer boundary, the PI of a reservoir with a no-flow condition at the outer boundary is shown to be more significantly hindered by the stress sensitivity of the reservoir rock.
Allocation of EV Public Charging Station in Renewable based Distribution Network using HHO Considering Uncertainties and Traffic Congestion
Authors: Pal Arnab , Bhattacharya Aniruddha , Chakraborty Ajoy Kumar 
Published: May 2021

Abstract
Electric vehicle (EV) is the growing vehicular technology for sustainable development to reduce carbon emission and to save fossil fuel. The charging station (CS) is necessary at appropriate locations to facilitate the EV owners to charge their vehicle as well as to keep the distribution system parameters within permissible limits. Besides that, the selection of a charging station is also a significant task for the EV user to reduce battery energy wastage while reaching the EV charging station. This paper presents a realistic solution for the allocation of public fast-charging stations (PFCS) along with solar distributed generation (SDG). A 33 node radial distribution network is superimposed with the corresponding traffic network to allocate PFCSs and SDGs. Two interconnected stages of optimization are used in this work. The first part deals with the optimization of PFCS’s locations and SDG’s locations with sizes, to minimize the energy loss and to improve voltage profile using harris hawk optimization (HHO) and few other soft computing techniques. The second part handles the proper assignment of EVs to the PFCSs with less consumption of the EV’s energy considering the road distances with traffic congestion using linear programming (LP), where the shortest paths are decided by Dijkstra's algorithm. The 2m point estimation method (2m PEM) is employed to handle the uncertainties associated with EVs and SDGs. The robustness of solutions are tested using wilcoxon signed rank test and quade test.
Bias correction of extreme values of high resolution climate simulations for risk analysis.
Authors: sanabria luis Augusto , Qin Xuerong , Li Jin , Cechet Robert Peter 
Published: May 2021

Abstract
Most climatic models show that climate change affects natural perils' frequency and severity. Quantifying the impact of future climate conditions on natural hazard is essential for mitigation and adaptation planning. One crucial factor to consider when using climate simulations projections is the inherent systematic differences (bias) of the modelled data compared with observations. This bias can originate from the modelling process, the techniques used for downscaling of results, and the ensembles' intrinsic variability. Analysis of climate simulations has shown that the biases associated with these data types can be significant. Hence, it is often necessary to correct the bias before the data can be reliably used for further analysis. Natural perils are often associated with extreme climatic conditions. Analysing trends in the tail end of distributions are already complicated because noise is much more prominent than that in the mean climate. The bias of the simulations can introduce significant errors in practical applications. In this paper, we present a methodology for bias correction of climate simulated data. The technique corrects the bias in both the body and the tail of the distribution (extreme values). As an illustration, maps of the 50 and 100-year Return Period of climate simulated Forest Fire Danger Index (FFDI) in Australia are presented and compared against the corresponding observation-based maps. The results show that the algorithm can substantially improve the calculation of simulation-based Return Periods. Forthcoming work will focus on the impact of climate change on these Return Periods considering future climate conditions.
Experimental study of pre- and postnatal caffeine exposure and its observable effects on selected neurotranmitters and behavioural attributes at puberty
Authors: Owolabi Joshua , Kehinde Adefule , Shallie Philemon , Fabiyi Oluseyi , Olatunji Sunday , Olanrewaju John , Ajibade Testimony , Oyewumi Samson , Ogunnaike Philip 
Published: May 2021

Abstract
Caffeine is globally consumed as a stimulant in beverage drinks; it is also ingested in purified forms as power and tablets. Concerns have been raised about the potential consequences of intrauterine and early life caffeine exposure on brain health. This study modeled caffeine exposure during pregnancy and early postanal life until puberty, and the potential consequences. Caffeine powder was dissolved in distilled water. Thirty-two (n = 32) pregnant mice (Mus musculus) were divided into four groups- A, B, C and D. Group A animals served as a control, receiving placebo. Caffeine doses in mg/kg body weight were administered as follows: Group B, 10mg/kg; Group C, 50mg/kg; Group D, 120mg/kg. Prenatal caffeine exposure [phase I] lasted throughout pregnancy. Half the number of offspring were sacrificed at birth; the rest were recruited into phase II and the experiment continued till day 35, marking puberty. Brain samples were processed following sacrifice. γ-aminobutyric acid (GABA), acetylcholine (ACh), and serotonin (5Ht) neurotransmitters were assayed in homogenates to evaluate functional neurochemistry. Anxiety and memory as neurobehavioural attributes were observed using the elevated plus and Barnes’ mazes respectively. Continuous caffeine exposure produced positive effects on short and long-term memory parameters; the pattern interestingly was irregular and appeared more effective with the lowest experimental dose. Anxiety test results showed no attributable significant aberrations. Caffeine exposure persistently altered the neurochemistry of selected neurotransmitters including ACh and 5Ht, including when exposure lasted only during pregnancy. ACh significantly increased in group BC+ to 0.3475µgg-1 relative to control’s 0.2508µgg-1; pre-and continuous postnatal exposure in Group B increased 5Ht to 0.2203 µgg-1 and 0.2213 µgg-1 respectively relative to control’s 0.1863 µgg-1. From the current investigation, caffeine exposure in pregnancy had persistent effects on brain functional attributes including neurotransmitters activities, memory and anxiety. Caffeine in moderate doses affected memory positively but produced negative effects at the higher dosage including increased anxiety tendencies.
The Effect of Workforce Birthplace Diversity on Firms: When do Migrants increase Firms’ Performance?
Authors: Misuraca Roberta , Annosi Maria Carmela , Carillo Maria Rosaria , Dolfsma Wilfred 
Published: May 2021

Abstract
Growing migration between countries and the sustained trend of globalization are changing business dynamics and creating conditions for increased workforce birthplace diversity within firms. However, few studies investigate the relationships between workforce birthplace diversity and firm performance. We address this, and also study how the impact of workplace birthplace diversity on firm performance is moderated by characteristics of the firms (firm size). We find that firm performance increases when workforce birthplace diversity increases. While larger firms perform better, smaller firms can make better use of birthplace diversity’s positive impact on firm performance. We analyzed a panel of 33,258 Italian firms operating in the agriculture sector between 2012 and 2017. Theoretical implications of our results are discussed, and further research is recommended to investigate appropriate internal mechanisms to enable firms to take advantage of workforce birthplace diversity.JEL: F22, J15, J61, Z1
Molecular markers confirm the presence of the alien snowflake coral Carijoa riisei (Octocorallia: Alcyonacea) in Cabo Verde Islands (Central-East Atlantic).
Authors: Lopes Evandro Pires , Freitas Rui , Xavier Raquel , Soares João Deus , Santos António M 
Published: May 2021

Abstract
The snowflake coral Carijoa riisei is one of the most invasive and successfully adapting species in the coastal marine environment. This species can disperse through ballast waters or fouling on the hull of ships, which allows it to expand very quickly to areas where it is not native. Recently C. riisei was identified in the Porto Grande Bay in São Vicente island in Cabo Verde Islands. We analysed mitochondrial and nuclear DNA sequences from specimens collected at this locality to determine the potential origin of this invasion. Lack of genetic variation in both mitochondrial and nuclear genes suggest a very recent invasion (bottleneck effect) but did not permit to establish its origin with total confidence.
Population Genetic Structure of Wild Boar And Dispersal Performance Based On Kinship Analysis In The Northern Region of South Korea
Authors: Han Seung Woo , Park Han Chan , Kim Jee Hyun , Suh Jae Hwa , Lee Hang , Min Mi Sook 
Published: May 2021

Abstract
Wild boar (Sus scrofa) is one of the most challenging mammalian species to manage in the wild because of its high reproductive rate, population density, and lack of predators in much of its range. A recent outbreak of African swine fever (ASF) and the transmission into domestic pigs in commercial farms empower the necessity of establishing management strategies of the wild boar population in the northern region of South Korea. A population genetic study, including the dispersal distance estimation of wild boars, is required to prepare fine-scale population management strategies in the region. In this study, both population structure analysis and dispersal distance estimation based on kinship were conducted using 13 microsatellite markers. The results revealed a high level of genetic diversity compared to a previous study. The population was not structured obviously, but there was a slight level of genetic differentiation between groups mainly formed by isolation by distance rather than mountain ridges. The dispersal distance estimation of Korean wild boars based on kinship analysis showed a philopatric pattern in females. However, extensive dispersal ability in both sexes was observed with a considerable proportion. The population genetic status and dispersal traits of wild boars may provide valuable data for planning detailed ASF and wild boar population management strategies in South Korea.
Twin Vaginal Deliveries: Impact of Delivery Time Interval on Twin B
Authors: Levine Elliot M , Ginsberg Norman A , Delfinado Leah , Ghobrial Mora 
Published: May 2021

Abstract
Background:A vaginal twin delivery is a natural commonplace occurrence, but which can sometimes present a concern which may require action. Recently, the delivery time interval has been recognized as a variable that can be helpful for its safe conduct.Objectives:To view the delivery time interval in an obstetric population undergoing a twin vaginal trial of labor in consecutive deliveries during a specified time period.Study Design:A retrospective observational cohort of twin vaginal trials of labor was investigated to view the delivery time interval and its association with other factors, such as birth weights and the need for cesarean delivery of the second twin. The twin deliveries were divided into 2 groups, those with a delivery time interval of ≤ 30 minutes (Group A) and those with a delivery time interval of > 30 minutes (Group B), in a single institution.Results:No perinatal outcome difference was found between Group A (248 patients) or Group B (72 patients). However, 13 patients in Group B required a cesarean birth for a safe delivery, and 3 patients in Group A. The birth weight difference between each Baby A and Baby B varied according to the delivery time interval. Conclusion:The delivery time interval for vaginal twin deliveries may be useful to predict the need for a cesarean delivery of the second twin. The birth weight difference between Baby A and Baby B may be responsible for this finding.
Dilemmas Regarding Abdominal Re-Exploration for War Casualties Following On-Site Abdominal Trauma Surgery and Subsequently Delayed Arrival to Medical Care Abroad – An Unusual Scenario
Authors: Bickel Amitai , Akinichev Konstantin , Weiss Michael , Ganam Samer , Kakiashvili Eli 
Published: May 2021

Abstract
Background: During the Syrian civil war, casualties were treated on-site and only later transferred to foreign medical centers. Significant number needed abdominal re-operation. Our aim is to present our approach to abdominal trauma casualties who survived the on-site surgery and needed abdominal reoperation abroad.Methods: Medical data from all medical records were retrospectively analyzed. Each patient underwent total body computerized tomography on arrival, revealing diverse multi-organ trauma. We divided the casualty population involving abdominal trauma into 4 sub-groups according to the location of abdominal surgical intervention, focusing on missed injuries and post-operative complications in the re-laparotomy sub-group. Results: By July 2018, 236 casualties suffering abdominal trauma (among 1331 trauma casualties) had been admitted to our hospital. Life-saving abdominal interventions had been done in 138 subjects in Syria before arrival to our medical center. Seventy-nine underwent abdominal surgery in Israel, of whom, 46 (33.3%) needed abdominal re-laparotomy. Indications for re-exploration included severe peritoneal inflammation, neglected abdominal foreign bodies, hemodynamic instability and intestinal fistula. Mortality occurred in 37/236 patients, with abdominal trauma as the main cause of fatality in 10 of them (4.2%), usually following urgent re-laparotomy. Conclusions: Clinical presentation of the Syrian casualties following emergency medical care outside our borders, and the fact that re-operation was not done by the same team responsible for the initial abdominal intervention posed major diagnostic challenges and necessitated increased suspicion and changes in our medical approach.
A Tumor of Composite Cervical Adenocarcinoma with MUCIN Gene Mutation：A Case Report
Authors: Guo Meijun , Li Guoping , Jiang Xiuxiu , Lv Shiming 
Published: May 2021

Abstract
Background:There are reports about the coexistence of two kinds of tumors in the same patient,which is believed that this phenomenon is caused by the dedifferentiation between the two tumors.In this paper, we report an human papillomavirus (HPV) negative cervical adenocarcinoma in a patient composed of two adenocarcinoma components,which is first reported.Histologically, both minimal deviation adenocarcinoma (MDA) and poorly differentiated gastric type adenocarcinoma (GTA) components, as well as their transitional area, were observed.Methods:This case of cervical cancer was screened by gene sequencing. For detection of specific somatic mutations in MDA and GTA, we filtered out mutations in malignant cervical cancer blood sample and 7 common cervical carcinoma. Then the genes were screened and identified based on the enrichment analysis of GO and KEGG and related literature reports. Results:We found 13 specific somatic gene mutations in total. Among these genes, only Mucin gene was transformed from gene level to protein level, and was positive in both MDA and GTA components of the patient by immunohistochemistry.Both components had genes mutation of MUC4 and MUC17,the component in MDA had gene mutation of MUC3A,and we found that MUC3A and MUC17 were on the same chromosome. Moreover,MUC3A and MUC4 genes were found to be fused in FusionGDB database. Conclusion:According to the reports of MUC3A,MUC4 and MUC17 genes mutation in cervical adenocarcinoma and gene fusions in tumorigenesis, we speculate that the occurrence of the transformation of pathological type from MDA to GTA in this case of cervical cancer is related to the mechanism of MUC3A and MUC4 gene fusion.We would advice, for HPV negative or atypical cervical lesions, immunohistochemistry of MUCIN genes staining and gene sequencing should be considered, which may find unusual cancer types and change the prognosis of patients.
SPOP Could Play a Potential Inhibitory Role in Human Renal Cell Carcinoma
Authors: chen zhi , Li Zuan , Nong Deyong , Li Ximing , Huang Guihai , Lin Junhao , Li Wei 
Published: May 2021

Abstract
Background: SPOP, a substrate adaptor of Cul3 ubiquitin ligase, plays crucial roles in solid neoplasms by promoting the ubiquitination and degradation of substrates. Limited studies have shown that SPOP is overexpressed in human renal cell carcinoma (RCC) tissue. However, the exact role of SPOP in RCC remains unclear and needs to be further elucidated. The present study showed that SPOP was expressed at different levels in different RCC cell lines. The purpose of this study was to explore the roles of SPOP in the biological features of RCC cells and determine the expression levels of SPOP in human tissue microarrays (TMAs) and kidney tissues.Methods: Here, SPOP was overexpressed by lentiviral vector transfection in ACHN and Caki-1 cells, and SPOP was knocked down in Caki-2 cells with similar transfection methods. The transfection efficiency was evaluated by quantitative PCR and western blotting analyses. The role of SPOP in the proliferation, migration, invasion and apoptosis of cell lines was determined by the MTT, wound-healing, Transwell and flow cytometry assays. Moreover, the cells were treated with different drug concentrations in proliferation and apoptosis assays to investigate the effect of sunitinib and IFN-α2b on the proliferation and apoptosis of SPOP-overexpressing cells and SPOP-knockdown RCC cells. Finally, immunohistochemical staining of SPOP was performed in kidney tissues and TMAs, which included RCC tissues and corresponding adjacent normal tissues.Results: Overexpression of SPOP inhibited cell proliferation, migration and invasion and increased cell apoptosis. Interestingly, sunitinib and IFN-α2b at several concentrations increased the proliferation inhibitory rate and total apoptosis rate of cells overexpressing SPOP. The findings of the present study showed that the SPOP protein was significantly expressed at low levels in most clear cell RCC (ccRCC) tissues and at relatively high levels in the majority of adjacent normal tissues and kidney tissues. Kaplan-Meier survival analysis showed that there was no statistically significant difference in cumulative survival based on the data of different SPOP expression levels in TMA and patients.Conclusions: In contrast to previous studies, our findings demonstrated that overexpression of SPOP might suppress the progression of RCC cells, which was supported by cell experiments and immunohistochemical staining. SPOP could be a potential tumour inhibitor in RCC.
Paleofluid flow: answers in the quartz.
Authors: Freville Kevin , Sizaret Stanislas 
Published: May 2021

Abstract
The search for carbon-free energy sources is at the heart of our concerns. It has become necessary to develop our capacities to harness the active energy flows of our environment while trying to have the lowest possible impact. Among these flows, one of the most stable is that linked to terrestrial thermal anomalies. Geothermal energy is an attractive option due to its regularity and the development of knowledge is encouraged, in France, by the national research funding agency. Geothermal systems are mainly associated with active hydrothermal circulations, fluids can be considered as a source of heat but also of metals. However, fluid circulation within active hydrothermal fields occurs at considerable depths and cannot be observed directly. In this study we propose a method for reconstructing the paleo-flow velocities recorded by quartz. The relative thickness of quartz growth bands is used to deduce the sense and velocity of the paleofluid flow. This contribution highlights the paleofluid flows velocities and the recharge/discharge area in the Limagne Basin geothermal province, which is currently under investigation. Finally, this study provides a tool to be used to study fossil hydrothermal systems containing quartz veins with comb textures.