bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low dose pig anti-influenza virus monoclonal antibodies reduce lung pathology but do not prevent virus shedding
Authors: Paudyal Basudev , McNee Adam , Rijal Pramila , Carr B. Veronica , Nunez Alejandro , McCauley John W. , Daniels Rodney S. , Townsend Alain R. , Hammond John A. , Tchilian Elma 
Published: October 2021

AbstractWe have established the pig, a large natural host animal for influenza, with many physiological similarities to humans, as a robust model for testing the therapeutic potential of monoclonal antibodies (mAbs). In this study we demonstrated that prophylactic intravenous administration of 15mg/kg of porcine mAb pb18, against the K160-163 site of the haemagglutinin, significantly reduced lung pathology and nasal virus shedding and eliminated virus from the lung of pigs following H1N1pdm09 challenge. When given at 1mg/kg, pb18 significantly reduced lung pathology and lung and BAL virus loads, but not nasal shedding. Similarly, when pb18 was given in combination with pb27, which recognised the K130 site, at 1mg/kg each, lung virus load and pathology were reduced, although without an apparent additive or synergistic effect. No evidence for mAb driven virus evolution was detected. These data indicate that intravenous administration of high doses was required to reduce nasal virus shedding, although this was inconsistent and seldom complete. In contrast the effect on lung pathology and lung virus load is consistent and is also seen at one log lower doses, strongly indicating that a lower dose might be sufficient to reduce severity of disease, but for prevention of transmission other measures would be needed.
Exploring maintaining gains following therapy during the coronavirus pandemic with adults with an intellectual disability
Authors: Purrington Jack , Nye Arthur , Beail Nigel 
Published: October 2021

Purpose
The novel coronavirus and associated mitigation efforts have caused significant increases in stress for adults with intellectual disabilities. Such increases in life stress predict an increased risk of relapse following psychological therapy. This contributes to the high global disease burden of common mental health difficulties. Therefore, this paper aims to explore service user experiences of maintaining gains following therapy within the context of the Covid-19 pandemic.

Design/methodology/approach
A mixed-methods evaluation was completed in a psychology service based in the North of England which specialises in supporting adults with intellectual disabilities. Descriptive statistics and effect size calculations were used to examine therapeutic outcomes pre-therapy, post-therapy, and at follow-up. These findings informed a framework analysis of eight semi-structured interviews.

Findings
Overall, outcome results improved post-therapy and regressed at follow-up. The framework analysis revealed facilitators to maintenance include a recollection of specific aspects of therapy and the regular utilisation of strategies and resources. Conversely, barriers to maintenance include a recollection focussed on personal outcome, a reliance on social support and an inability to remember therapy.

Originality/value
This is the only study to the authors’ knowledge examining service user experiences of maintaining gains following therapy within the context of Covid-19. It is hoped that these findings will inform further research and be useful for services in preparing service users for discharge as the Covid-19 pandemic continues and moves towards the post-pandemic phase.
Risk, competition, efficiency and its interrelationships: evidence from the Chinese banking industry
Authors: Tan Yong , Charles Vincent , Belimam Doha , Dastgir Shabbir 
Published: October 2021

PurposeThis study investigates the interrelationships between efficiency, competition and risk in the Chinese banking industry.Design/methodology/approachParametric stochastic frontier analysis is used to estimate bank efficiency; the Lerner index is used as the competition indicator; accounting ratios and a translog function are used to measure different types of risk and finally, the three-stage least square estimator is used to investigate the interrelationships.FindingsThe results of this study show that the impact of competition on different types of risk is significant and positive, while there is a significant and positive impact of credit risk, liquidity risk and capital risk on bank competition. In addition, the findings demonstrate that the interrelationships between efficiency and competition are significant and negative. The authors do not find any robust interrelationships between different types of risk and different types of efficiency; the authors find that diversification and higher levels of profitability reduce bank credit risk. The results suggest that a higher developed banking sector reduces the level of bank competition in China.Originality/valueThis is the first piece of research that comprehensively investigates the interrelationships between different types of risk, competition and different efficiencies in China.
Ranking of performance indicators in an Internet of Things (IoT)-based traceability system for the agriculture supply chain (ASC)
Authors: Yadav Sanjeev , Garg Dixit , Luthra Sunil 
Published: October 2021

PurposeThe prime aim of this paper is the identification and prioritization of performance indicators, which motivate the development of an Internet of Things (IoT)-based traceability system for the agriculture supply chain (ASC). Also, this research aims for checking the robustness of obtained results.Design/methodology/approachTen performance indicators have been identified based on the five “criteria in the IoT-based traceable system”. Further, based on five criteria, performance indicators were ranked by using grey-based “Additive Ratio Assessment”.FindingsSustainable practices obtained first rank, and certification of agri-products obtained worst ranking. Further, based on sensitivity analysis, tracking of agri-products and stakeholders' behavior have found high sensitivity. Also, information sharing and global distribution networks have found the least sensitive performance indicators.Research limitations/implicationsThis research has some limitations of taking only a few criteria and alternatives. This study may also contribute as a practical insight to the practitioners and managers in decision-making in the adoption of an IoT-based traceable system within the ASC.Originality/valueThis research may motivate the implementation of an IoT-based efficient traceability mechanism that improved the sustainability and consumer's trust in the ASC during different types of hazardous activities and other outbreaks (COVID-19). Also, this research has provided a theoretical insight based on the dynamic capability theory (DCT).
Using the theory of planned behavior to understand the students’ pro-environmental behavior: a case-study in a Portuguese HEI
Authors: Correia Elisabete , Sousa Sara , Viseu Clara , Leite Joana 
Published: October 2021

Purpose
Through the application of the theory of planned behavior (TPB), this study aims to explore the main determinants of higher education students’ pro-environmental behavior.

Design/methodology/approach
An online survey was conducted among the students of a public higher education institution (HEI) in Portugal, from March to May of 2020. The data were analyzed with the structural equation modeling technique, considering environmental attitude, knowledge, subjective norm and perceived behavioral control as exogenous latent variables, and pro-environmental intention and behavior as endogenous latent variables.

Findings
The results show that the students’ environmental attitude and knowledge have no significant impact on their pro-environmental intention, while the students’ subjective norm and perceived behavioral control have a positive impact on their pro-environmental intention. The results also reveal that the students’ perceived behavioral control and pro-environmental intention have a strong and positive impact on their pro-environmental behavior.

Research limitations/implications
This study focuses on the students from a single public HEI, in accounting and administration area, and deepens environmental behavior in relation to resources’ consumption.

Practical implications
This study provides findings that can be useful for HEIs to be more effective in their policies, strategies and practices to improve students’ environmental behavior.

Originality/value
The paper contributes to the literature by exploring the main determinants of higher education students’ pro-environmental behavior in a Portuguese HEI and extending the TPB considering the additional variable environmental knowledge.
Choice of certification schemes by smallholder pineapple farmers in Ghana: analysis of constraints and determinants of adoption
Authors: Quartey Comfort Love Naa Kwaale , Osei Mensah James , Nimoh Fred , Adams Faizal , Etuah Seth 
Published: October 2021

PurposeThe main purpose of this study was to assess constraints and determinants of pineapple farmers' choice of certification schemes in Ghana.Design/methodology/approachA multistage sampling method was used to solicit data from 345 pineapple farmers from Eastern and Central regions of Ghana. Analytical techniques including descriptive statistics, four-point Likert scale index and multinomial logistic regression model (MNL) were used to analyze the data.FindingsThe four-point scale index shows that high renewal fee for certification schemes is the most important constraint facing certified farmers before high labor cost of production. The MNL model shows that both off-farm income and age negatively influenced farmers' choice of GlobalG.A.P scheme. However, household size had significant positive influence on farmers' choice of GlobalG.A.P and Organic schemes. Likewise, formal education had significant positive relationship with the choice of Fairtrade and Organic certification schemes while farming experience positively influenced organic scheme choice. On the other hand, premium price and extension services positively influenced the likelihood of choosing all the three certification schemes. Lastly, regional dummy only negatively influences the choice of organic certification schemes.Research limitations/implicationsThis study contributes to the literature on certification schemes adopted by smallholder by analyzing the determinants and constraints of choice of scheme(s).Originality/valueThe study brings to bear the issues confronting smallholder pineapple farmers in the employment of certification schemes in developing countries, specifically Ghana.
Stability of Borna disease virus‐based episomal vector under physical and chemical stimulation
Authors: Yanai Mako , Sakai Madoka , Komorizono Ryo , Makino Akiko , Tomonaga Keizo 
Published: October 2021

AbstractBorna disease virus (BoDV), a nonsegmented, negative‐sense RNA virus, establishes persistent infection and replicates in the cell nucleus. Since BoDV genomic RNA exists as episomal RNA, the host genome is not invaded by BoDV infection. These unique features make BoDV a promising gene delivery system as an RNA virus‐based episomal vector (REVec). Previously, the stable expression of genes of interest in vitro and in vivo using a REVec was reported. For the clinical application of a REVec, the fundamental properties under various physical and chemical conditions must be determined to develop purification processes, supply chains, and biosafety management. This study investigated the effects of the following conditions on the inducibility of transmission‐defective ΔG‐REVec: freeze–thaw cycles, dehydration, UV, temperature, pH, and reagents for virucides and laboratory experiments. Although the titer of ΔG‐REVec was not influenced by the freeze–thaw process or 5 minute incubation at ≤50°C, ΔG‐REVec was significantly inactivated by incubation at ≥70°C for 5 minutes. The induction titer of ΔG‐REVec was decreased by long‐term incubation, dehydration, and UV irradiation in a temperature‐ and time‐dependent manner. ΔG‐REVec was sensitive to lower pH and inactivated by chemical reagents under general conditions. These results provide important knowledge for developing the clinical use of REVec and biosafety management.
Viral adaptations to vector‐borne transmission can result in complex host–vector–pathogen interactions
Authors: Wilfert Lena 
Published: October 2021

AbstractResearch Highlight: Norton, A. M., Remnant, E. J., Tom, J., Buchmann, G., Blacquiere, T., & Beekman, M. (2021). Adaptation to vector‐based transmission in a honeybee virus. Journal of Animal Ecology, 90, https://besjournals.onlinelibrary.wiley.com/doi/10.1111/1365‐2656.13493.In their paper on the adaptation to vector‐based transmission via the mite Varroa destructor in a honeybee virus, Norton et al. study how high versus low levels of a viral vector affect viral load and potential competition between two strains of Deformed Wing Virus, an important highly virulent bee virus with the potential to spill‐over into other pollinators and bee‐associated insect species. This paper addresses two very timely issues, on the one hand on viral evolutionary ecology in response to vector‐borne transmission, and on the other hand providing much needed information on an important honey bee pathogen. Using a complex natural system, this study shows that vector‐borne transmission, and the control of the vector, can select for complex host–pathogen–vector interactions and that adaptations to changing transmission landscapes in fast evolving pathogens can create conditions for emerging pathogens to transition to endemic diseases.
Dancing bees evaluate central urban forage resources as superior to agricultural land
Authors: Samuelson Ash E. , Schürch Roger , Leadbeater Ellouise 
Published: October 2021

Abstract

Recent evidence suggests that flower‐rich areas within cities could play an important role in pollinator conservation, but direct comparison of floral resources within agricultural and urban areas has proved challenging to perform over large scales.

Here we use the waggle dances of honeybees Apis mellifera L. to perform large‐scale landscape surveys at heavily urban or agricultural sites for a key pollinator of wild and crop plants. We analysed 2,827 dances that were performed by 20 colonies in SE England.

We show that hive median foraging trip distance is consistently lower at urban sites across the entire season. The sucrose content of collected nectar did not significantly differ between urban and agricultural land, ruling out the possibility that longer foraging distances in agricultural sites were driven by distant but nectar‐rich resources.

Within cities, bees preferentially targeted residential areas on foraging trips, while trips to mass‐flowering crops overwhelmingly dominated at agricultural sites. For both land‐use types, distances flown increased in the summer, but there was high variation in temporal patterns between individual sites.

Policy implications. From the self‐reported perspective of a generalist pollinator, forage was easier to find in heavily urbanized areas than in the modern agricultural landscapes that we studied. A focus on continuous spatial and temporal provision within agricultural environments is key to redressing this imbalance.
Corporate Governance in Extreme Institutional Environments
Authors: Cumming Douglas , Girardone Claudia , Śliwa Martyna 
Published: October 2021

AbstractThis paper reviews the literature on corporate governance in extreme institutional environments, including both formal and informal institutions. We focus on three main areas of research: corporate governance in an international context, banking and corporate governance, and governance in entrepreneurship and innovation. We document some classic papers in each of these areas and explain how the papers in this special issue contribute to the development of these areas of research. We discuss recommendations for policy and practice and offer suggestions for future research.
What Form would Referendums on Irish Unification take?
Authors: Renwick Alan , Kelly Conor J. 
Published: October 2021

AbstractThe Belfast or Good Friday Agreement of 1998 makes provision for Northern Ireland to leave the United Kingdom and join a united Ireland through a unification referendum, if voters so wish. Yet, the provision is short on detail and has not been substantively explored. A Working Group on Unification Referendums on the Island of Ireland has recently sought to address this gap. In this article, the Working Group's chair and research assistant outline the project's methodology and key findings, covering overall referendum configurations and specific design features, as well as what steps might be taken in the coming years. The article also highlights two comparative lessons, relating to tensions between the values of informed consent and inclusive design, and between majoritarian and consensual politics. These tensions afflict many referendums, particularly on sovereignty questions. They cannot be resolved, but only tempered, through careful and inclusive design of referendum processes.
Personal Financial Distress, Limited Attention
Authors: ASLAN HADIYE 
Published: October 2021

ABSTRACTBy linking sell‐side equity analysts to their deed records and LinkedIn profiles, I show that analysts with higher exposure to negative wealth shocks issue more pessimistic and less accurate forecasts. The effects are stronger when analysts have higher leverage in their homes and face career concerns. I also find that stocks recommended by exposed analysts underperform those of nonexposed counterparts, by an amount that is significant and economically large in magnitude. The results remain robust to unobserved skill differences, the potential endogeneity of housing prices, the self‐selection of analysts into neighborhoods with certain traits, and placebo tests where housing wealth shocks are randomized across analysts. Collectively, this study provides new evidence on if and how personal wealth shocks impact analysts' work productivity and forecast behavior.
Papaya and pineapple juices facilitate rehydration of mummified dermal tissue for fingerprint capture
Authors: Fernandez Fidel , Thumaty Neehar , Climer Cailin R. , Escorcia Wilber 
Published: October 2021

AbstractMummified remains pose an issue for forensic scientists as identification of the deceased can be difficult due to extreme shriveling of dermal tissue and a resulting lack of quality fingerprint features. The typical protocols used to address this problem include corrosive chemicals that may further damage the already susceptible tissues. An alternative approach is found in the juice of two fruit species known to contain proteolytically active enzymes that tenderize soft tissues, thereby promoting water uptake. In this study, we saturated mummified fingers in papaya and pineapple juice treatments, followed by syringe‐facilitated finger volume distension. After juice saturation, the data showed statistically significant increases in mass and volume of the samples, (papaya: relative mass p < 0.02833, relative volume p < 0.008466; pineapple: relative mass p < 0.01426, relative volume p < 0.04182). The post‐treatment tissues were then rehydrated through a hydraulic mechanism that exerted the required turgor for effective fingerprint capture. This novel protocol utilizes fruit‐based reagents to rehydrate mummified fingers without risk of corrosive damage, allowing for the restoration of accurate fingerprints and the positive identification of decedents. The value of this protocol lies in its simple implementation, affordability, instrument availability, and time effectiveness.
Different pipe burial depths associated with subsurface drip irrigation significantly affected soil gas emissions
Authors: Wang Jingwei , Yao Ziyan , Han Jinxian , Niu Wenquan , Li Yuan 
Published: October 2021

AbstractEfforts are needed to reduce soil greenhouse gas emissions from irrigated croplands. Thus, in this study, patterns of soil carbon dioxide (CO2) and nitrous oxide (N2O) emissions in the root zone of tomato plants grown under subsurface drip irrigation (SDI) involving different pipe burial depths were studied, with surface drip irrigation (DI) used as a control (CK). The soil CO2and N2O emission curves under DI and SDI with pipe burial depths of 10 and 20 cm tended to be similar. In contrast, SDI with a pipe depth of 30 cm resulted in peak CO2and N2O emissions occurring at different times. The different pipe burial depths led to significantly different spatial distributions of soil water‐filled pore space, which indirectly affected root–soil interactions and soil gas emissions through direct effects on total tomato root fork numbers and microbial community composition. The SDI treatments involving 10‐ and 20‐cm pipe burial depths increased the number of root forks to 1.85 and 2.77 times that in the DI treatment, respectively, and increased the Shannon index of the fungal community by 11.9 and 7.29% compared with that in the DI treatment, respectively. The SDI treatment involving the 30‐cm pipe burial depth resulted in 2.22 times the number of root forks compared with that in the DI treatment; however, the Shannon index of the fungal community decreased by 13.6% compared with that in the DI treatment. As a result, the total soil CO2emissions and total soil N2O emissions in the SDI treatment involving the 10‐cm pipe burial depth were 1.37 and 2.03 times those in the DI treatment, and those in the SDI treatment involving the 20‐cm pipe burial depth were 1.33 and 2.17 times those in the DI treatment, respectively. In the SDI treatment involving the 30‐cm pipe burial depth, the total amount of soil CO2emissions was similar to that in the DI treatment; however, the total amount of soil N2O emissions was 28.98% lower than that in the DI treatment. Therefore, soil gas emissions can be reduced by increasing the burial depth of irrigation pipes. These results provide insights into the control of soil gas emissions in agroecosystems.
Mitochondrial DNA copy number and heteroplasmy load correlate with skeletal muscle oxidative capacity by P31 MR spectroscopy
Authors: Tian Qu , Moore Ann Zenobia , Oppong Richard , Ding Jun , Zampino Marta , Fishbein Kenneth W. , Spencer Richard G. , Ferrucci Luigi 
Published: October 2021

AbstractThe association between blood‐based estimates of mitochondrial DNA parameters, mitochondrial DNA copy number (mtDNA‐CN) and heteroplasmy load, with skeletal muscle bioenergetic capacity was evaluated in 230 participants of the Baltimore Longitudinal Study of Aging (mean age:74.7 years, 53% women). Participants in the study sample had concurrent data on muscle oxidative capacity (τPCr) assessed by 31P magnetic resonance spectroscopy, and mitochondrial DNA parameters estimated from whole‐genome sequencing data. In multivariable linear regression models, adjusted for age, sex, extent of phosphocreatine (PCr) depletion, autosomal sequencing coverage, white blood cell total, and differential count, as well as platelet count, mtDNA‐CN and heteroplasmy load were not significantly associated with τPCr (both p > 0.05). However, in models evaluating whether the association between mtDNA‐CN and τPCr varied by heteroplasmy load, there was a significant interaction between mtDNA‐CN and heteroplasmy load (p = 0.037). In stratified analysis, higher mtDNA‐CN was significantly associated with lower τPCr among participants with high heteroplasmy load (n = 84, β (SE) = −0.236 (0.115), p‐value = 0.044), but not in those with low heteroplasmy load (n = 146, β (SE) = 0.046 (0.119), p‐value = 0.702). Taken together, mtDNA‐CN and heteroplasmy load provide information on muscle bioenergetics. Thus, mitochondrial DNA parameters may be considered proxy measures of mitochondrial function that can be used in large epidemiological studies, especially when comparing subgroups.