bluuebunny/crossref_metadata_2025_split huggingface dataset:
The immunogenicity and safety of different COVID-19 booster vaccination following CoronaVac or ChAdOx1 nCoV-19 primary series
Authors: Angkasekwinai Nasikarn , Niyomnaitham Suvimol , Sewatanon Jaturon , Phumiamorn Supaporn , Sukapirom Kasama , Senawong Sansnee , Mahasirimongkol Surakameth , Toh Zheng Quan , Umrod Pinklow , Somporn Thitiporn , Chumpol Supaporn , Ritthitham Kanokphon , Chokephaibulkit Kulkanya 
Published: December 2021

Abstract
The appropriate COVID-19 booster vaccine following inactivated or adenoviral vector COVID-19 vaccination is unclear. We evaluated the safety and immunogenicity of different booster vaccines, inactivated (BBIBP-CorV), chimpanzee adenoviral vector (ChAdOx1), or mRNA (BNT162b2 at full (30 µg), or half (15 µg) dose) in healthy adults who received 2-dose primary series of either inactivated vaccine (CoronaVac) or ChAdOx1 8-12 weeks earlier. Overall, the adverse events for all booster vaccines were mild and moderate. Two weeks post-booster dose, the neutralising antibody titres against Delta variant in CoronaVac-prime and ChAdOx1-prime were highest with for 30µg-BNT162b2 (411 vs 470) and 15µg-BNT162b2 (499 vs 358); followed by ChAdOx1 (271 vs 69), and BBIBP-CorV (61.3 vs 49). BNT162b2 also induced higher interferon gamma response. Heterologous COVID-19 boosting vaccination with BNT162b2 is the most immunogenic following CoronaVac or ChAdOx1 primary series. A lower dose BNT162b2 may be used as booster in settings with limited vaccine supply.
Effects of Sleep Disturbance on Neuropsychological Functioning in Patients with Pediatric Brain Tumor
Authors: Chiang Jenna A. , Feghali Paulina T. , Saavedra Anita , Whitaker Ashley M. 
Published: December 2021

Abstract
Purpose While the effects of sleep on cognition in typically developing children are well established, there is a paucity of research in patients with pediatric brain tumor (PBT), despite their increased risk for sleep-related disturbances. The aim of this study was to examine the impact of sleep factors on patient-reported outcome (PRO) measures, including adaptive and executive functioning within this population.Methods 133 patients with PBT (52% male) ages 5-23 (x̄ = 12.8yrs; SD = 4.5yrs) underwent neuropsychological evaluation, including assessment of adaptive and executive functioning. Subjective sleep concerns, nocturnal sleep duration, and daytime sleep behavior were also collected and compared to age-based guidelines.Results Nearly 30% of patients reported subjective sleep concerns, while the sample as a whole presented with reduced nocturnal sleep duration (approximately one hour below age-based recommendations). Despite the expectation for monophasic sleep by age five, nearly half of the sample reported consistent daytime napping. With regard to functional outcomes, inadequate sleep predicted decreased adaptive functioning, F(1, 56) = 4.23, p < .05 (R2 = .07), as well as increased symptoms of executive dysfunction, F(1, 108) = 3.51, p < .05 (R2 = .03).Conclusion Patients with PBT demonstrate several aspects of abnormal sleep, which are associated with poorer long-term PROs. Further exploration of diagnostic, treatment-related, and demographic variables will be needed to better understand these relationships among patients with PBT in order to inform appropriate interventions.
A New Type of Cemented Sand-Gravel (CSG) Mixtures for Water-Tightening of Hardfill Dams
Authors: Karimi Sina , Aghajani Hamed Farshbaf 
Published: December 2021

Abstract
This paper aims to achieve a specific type of cemented sand-gravel mixtures with low permeability to implement in the impervious zone of hardfill dams. To this end, various mixtures are prepared by blending two native soils of sand and gravel with different amounts of kaolinite or bentonite additives in presence of various cement content. The compaction properties, uniaxial compressive strength, permeability and scanning electron microscope (SEM) images of mixtures are measured. According to the results, the cemented mixture containing 10% of kaolinite additive regardless of native soil type exhibits the maximum strength. However, the bentonite disturbs the cement hydration in the mixture, and the strength of mixtures especially with high cement content decreases with increasing the bentonite content. The permeability of mixtures is related to the amount of cement and fine additive in the mixture. The permeability of both cemented sand and gravel mixtures decreases with increasing the bentonite additive. However, the kaolinite additive has a limited influence on the permeability of cemented gravel mixtures. The lowest permeability is achieved in the mixture involving the higher amount of bentonite (with a weight ratio of 30%) in presence of adequate cement.
Genome-Wide Superior Alleles, Haplotypes and Candidate Genes Associated With Tolerance on Sodic-Dispersive Soils in Wheat (Triticum Aestivum L.)
Authors: Sharma Darshan Lal , Bhoite Roopali , Reeves Karyn , Forrest Kerrie , Smith Rosemary , Dowla Mirza A.N.N.U. 
Published: December 2021

Abstract
Sodic-dispersive soils have multiple subsoil constraints including poor soil structure, alkaline pH and subsoil toxic elemental ion concentration, affecting growth and development in wheat. Tolerance is required at all developmental stages to enhance wheat yield potential on such soils. An in-depth investigation of genome-wide associations was conducted using a field phenotypic data of 206 diverse Focused Identification of Germplasm Strategy (FIGS) wheat lines for two consecutive years from different sodic and non-sodic plots and the exome targeted genotyping by sequencing (tGBS) assay. A total of 39 quantitative trait SNPs (QTSs), including 18 haplotypes were identified on chromosome 1A, 1B, 1D, 2A, 2B, 2D, 3A, 3B, 5A, 5D, 6B, 7A, 7B, 7D for yield and yield-components tolerance. Among these, three QTSs had common associations for multiple traits, indicating pleiotropism and four QTSs had close associations for multiple traits, within 32.38 Mb. The overlapping metal ion binding (Mn, Ca, Zn and Al) and photosynthesis genes, and transcription factors (PHD-, Dof-, HTH myb-, BHLH-, PDZ_6-domain) identified are known to be highly regulated during germination, maximum stem elongation, anthesis, and grain development stages. The homozygous/biallelic SNPs having allele frequency above 30% were identified for yield and crop establishment/plants m-2. These SNPs correspond to HTH myb-type and BHLH transcription factors, brassinosteroid signaling pathway, kinase activity, ATP and chitin binding activity. These resources are valuable in haplotype-based breeding and genome editing to improve yield potential on sodic-dispersive soils.
Senescence as a Dictator of Patient Outcomes and Therapeutic Efficacies in Human Gastric Cancer
Authors: Sun Qiang , Zhou Lulin , Niu Zubiao , Wang Yuqi , Zheng You , Zhu Yichao , Wang Chenxi , Gao Xiaoyan , Gao Li-Hua , Zhang Wen , Zhang Kaitai , Melino Gerry , HUANG HONGYAN , Wang Xiao-ning 
Published: December 2021

Abstract
Senescence is believed to be a pivotal player in the onset and progression of tumors as well as cancer therapy. However, the guiding roles of senescence in clinical outcomes and therapy selection for patients with cancer remains obscure, largely due to the absence of a feasible senescence signature. Here, by integrative analysis of single cell and bulk transcriptome data from multiple datasets of gastric cancer patients, we uncovered senescence as a veiled tumour feature characterized by senescence gene signature enriched, unexpectedly, in the non-cancerous cells, and further identified two distinct senescence-associated subtypes based on the unsupervised clustering. Patients with the senescence subtype had higher tumor mutation loads and better prognosis as compared with the aggressive subtype. By the machine learning, we constructed a scoring system termed as senescore based on 6 signature genes: ADH1B, IL1A, SERPINE1, SPARC, EZH2 and TNFAIP2. Higher senescore demonstrated robustly predictive capability for longer overall and recurrence-free survival in 2290 gastric cancer samples, which was independently validated by the multiplex staining analysis of gastric cancer samples on the tissue microarray. Remarkably, the senescore signature served as a reliable predictor of chemo- and immuno-therapeutic efficacies, with high-senescore patients benefited from immunotherapy while low-senescore patients were responsive to chemotherapy. Collectively, we report senescence as a heretofore unrecognized hallmark of gastric cancer that impacts patient outcomes and therapeutic efficacy.
Impact of Volume-Based Drug Procurement Policy on Drug Use Structure of Chinese Public Medical Institutions: A Difference-in-Difference Analysis of Nine Pilot Cities and Twelve Non-pilot Provinces
Authors: Lu Jiancheng , Yang Ying , Long Hongfei , Wang Jing , Shen Yuan , Cui Dan , Mao Zongfu , Li Jinghua 
Published: December 2021

Abstract
Background
In 2019, the Chinese government implemented the first round pilot of volume-based drug procurement in 4 municipalities and 7 sub-provincial cities, i.e. “4+7” policy. This study evaluated the impact of “4+7” policy on the use structure of policy-related drugs.
Methods
Data of China Drug Supply Information Platform (CDSIP) database was used, covering 18,636 public medical institutions from 9 pilot cities and 12 non-pilot provinces in mainland China. “4+7” policy-related drugs were selected as study samples, including 25 drugs in the “4+7” procurement List and 83 alternative drugs that have an alternative relationship with “4+7” List drugs. “4+7” List drugs were divided into bid-winning and bid-non-winning products. Drug Structure Index (DSI) was employed as the outcome variable, and higher DSI refers to the use proportion of higher-DDDc (Defined Daily Drug cost) drugs increased. Difference-in-difference (DID) method was employed to estimate the net effect of “4+7” policy.
Results
After policy intervention, the DSI of bid-winning drugs significantly decreased (β=-0.233, p<0.0001), while non-winning drugs (β = 0.177, p<0.001) and “4+7” List drugs (β = 0.050, p<0.01) increased. No significant change was found for the overall DSI of alternative drugs (β = 0.013, p>0.05), while a remarkable increase was found in primary healthcare settings (β = 0.033, p<0.05). In three post-“4+7” periods, the increments of DSI for non-winning products were 17.54% (period 1), 18.35% (period 2), and 19.66% (period 3). The DSI of “4+7” List drugs significantly increased in post-“4+7” period 2 and 3 (all p-values<0.05).
Conclusions
The use proportion of higher-DDDc bid-winning drugs significantly decreased after policy intervention. However, among drugs not involved by NCDP policy, the use proportion of higher-DDDc drugs significantly increased after policy intervention, moreover, the increment was more pronounced at the later periods of policy implementation. The clinical use monitoring and the physician’s prescription behavior supervision should be strengthened.
Safety and Efficacy of Cabozantinib for Patients with Advanced Hepatocellular Carcinoma and Child-Pugh B Liver Function: Retrospective Analysis From the CELESTIAL Randomised Controlled Trial
Authors: El-Khoueiry Anthony B. , Meyer Tim , Cheng Ann-Lii , Rimassa Lorenza , Sen Suvajit , Milwee Steven , Kelley Robin Kate , Abou-Alfa Ghassan K. 
Published: December 2021

Abstract
Background: Patients with hepatocellular carcinoma (HCC) and Child-Pugh B liver cirrhosis have poor prognosis and are underrepresented in clinical trials. The CELESTIAL trial, in which cabozantinib improved overall survival (OS) and progression-free survival (PFS) versus placebo in patients with HCC and Child-Pugh A liver cirrhosis at baseline, was evaluated for outcomes in patients who had Child-Pugh B cirrhosis at Week 8. Methods: This was a retrospective analysis of adult patients with previously treated advanced HCC. Child-Pugh B status was assessed by the investigator. Patients were randomised 2:1 to cabozantinib (60 mg once daily) or placebo. Results: Fifty-one patients receiving cabozantinib and 22 receiving placebo had Child-Pugh B cirrhosis at Week 8. Safety and tolerability of cabozantinib for the Child-Pugh B subgroup were consistent with the overall population. For cabozantinib- versus placebo-treated patients, median OS from randomisation was 8.5 versus 3.8 months (HR 0.32, 95% CI 0.18–0.58), median PFS was 3.7 versus 1.9 months (HR 0.44, 95% CI 0.25–0.76), and best response was stable disease in 57% versus 23% of patients. Conclusions: These encouraging results with cabozantinib support the initiation of prospective studies in patients with advanced HCC and Child-Pugh B liver function.Clinical Trial Registration: NCT01908426
Outlining the Challenges of COVID-19 Pandemic on Africa’s Maritime Industry: the Case of Marine and Seafaring Professionals
Authors: Sackey Anthony Djaba , Tchouangeup Bertrand , Lomotey Bernard , Lamptey Benjamin Lantei , Lee Raphael Ofosu-Dua , Sackey ABIGAIL Dede , Segbefia Joseph Elorm , Teye Abraham Akwertey , Quarcoo Richmond Kennedy , Bansah John , Ewedji Christabel , Wood Ekow Eduhene 
Published: December 2021

Abstract
Despite the ‘Key Worker’ status accorded seafarers in moments of demonstrable selflessness -ensuring, adequate supply of food, medicines, consumables like personal protective equipment (PPEs), and energy - there is a lack of genuine interest in their concerns, leading to various calls from major stakeholders such as the United Nations and International Maritime Organization. These calls associate- with various covid-19-related policies and regulations having a direct bearing on the ongoing crew change crises, maroon and overstay of contracts, poor mental health, rise in covid-19 infections and other unrelated illnesses among ship crew. Thus, to what extent are non-traditional seafaring nations of Africa being impacted? The study examines these concerns by identifying and investigating implemented covid-19 policies and regulations and their impact on maritime operations and crew ‘wellbeing;’ the contingency measures and innovations aiding mitigate responses with minimal challenges to seafarers and marine professionals. The case study approach focuses on West Africa’s maritime corridor, examining operations in Ghana, Ivory Coast, Liberia, Nigeria and Angola to a host of varied ports and offshore installations operations. Direct field observations, as well as questionnaires and interviews of expert or ‘eye witness’ account, deployed via phone calls, online social media and emails are carried out. The study finds MLC 2006 was not been complied with. Embarkation quarantine measures and testing implemented for offshore Ghana and Angola could not prevent the outbreak of cases onboard FPSO units respectively, though the process identified positive cases during quarantine. The stigma associated with positive cases amongst the crew were prevalent in the first six months of pandemic declaration. Of the survey conducted amongst 71 vessel crew, 32.14% were certain of having recorded Covid-19 positive cases on their various Jobsites, 91.06% showed support for IMO-led interventions against covid-19, 30% complained of uncertainty spared by rumours as fueling poor mental health. However, only 19% willingly addressed issues of their proximity to covid-19. Vaccine inoculations upon commencing March 2021 remained low in the region amongst marine professionals. Mitigating measures implemented include increased internet and call access, and extensive boarding protocols. In conclusion, lessons learnt within these periods of history going forward should inform the need for a comprehensively developed global emergency response contingency regulatory plan that identifies various potential threats, establishes adequate measures and make adjustment for review and amendments –to be instated only in times of global emergencies.
Functionalized Porous Nanoscale Fe3O4 Particles Supported Biochar From Peanut Shell For Pb(II) Ions Removal From Landscape Wastewater
Authors: Jin Xiaojun , Liu Renrong , Wang Huifang , Han Li , Qiu Muqing , Hu Baowei 
Published: December 2021

Abstract
The large amounts of heavy metal from landscape wastewater have become serious problems of environmental pollution and risks for human health. It affects the growth of plant and aquatic, and leads to the destruction of landscape. Therefore, the development of efficient novel adsorbent is a very important for treatment of heavy metal. A low-cost and easily obtained agricultural waste (Peanut Shell) was modified by nanoscale Fe3O4 particles. Then, the functionalized porous nanoscale Fe3O4 particles supported biochar from peanut shell (PS-Fe3O4) for removal of Pb(II) ions from aqueous solution was investigated. The characterization of PS-Fe3O4 composites showed that PS from peanut shell was successfully coated with porous nanoscale Fe3O4 particles. The pseudo second-order kinetic model and Langmuir model were more fitted for describing the adsorption process of Pb(II) ions in solution. The maximum adsorption capacity of Pb(II) ions removal in solution by PS-Fe3O4 composites could reach 188.68 mg/g. The adsorption process of Pb(II) ions removal by PS-Fe3O4 composites was a spontaneous and endothermic process. The adsorption mechanisms of Pb(II) ions by PS-Fe3O4 composites were mainly controlled by the chemical adsorption process. They included Fe-O coordination reaction, co-precipitation, complexation reaction and ion exchange. PS-Fe3O4 composites were thought as a low-cost, good regeneration performance and high efficiency adsorption material for removal of Pb(II) ions in solution.
First report of Seville root-knot nematode, Meloidogyne hispanica (Nematoda: Meloidogynidae) in the USA and North America
Authors: Skantar Andrea M. , Handoo Zafar A. , Subbotin Sergei A. , Kantor Mihail R. , Vieira Paulo , Agudelo Paula , Hult Maria N. , Rogers Stephen 
Published: December 2021

Abstract
A high number of second stage juveniles of the root-knot nematode were recovered from soil samples collected from a corn field, located in Pickens County, South Carolina, USA in 2019. Extracted nematodes were examined morphologically and molecularly for species identification which indicated that the specimens of root knot juveniles were Meloidogyne hispanica. The morphological examination and morphometric details from second-stage juveniles were consistent with the original description and redescriptions of this species. The ITS rRNA, D2-D3 expansion segments of 28S rRNA, intergenic COII-16S region, nad5 and COI gene sequences were obtained from the South Carolina population of M. hispanica. Phylogenetic analysis of the intergenic COII-16S region of mtDNA gene sequence alignment using statistical parsimony showed that the South Carolina population clustered with Meloidogyne hispanica from Portugal and Australia. To our best knowledge, this finding represents the first report of Meloidogyne hispanica in the USA and North America.
The influence of OH content on elastic constants of topaz [Al2SiO4(F,OH)2]
Authors: Aradachi Kako , Hamada Morihisa , Tsuge Kiyoshi , Watanabe Tohru 
Published: December 2021

Abstract
Topaz, Al2SiO4(OH)xF(2–x), may play a significant role in transporting water and fluorine into the Earth’s interior at subduction zones. Seismological detection of topaz gives us insights into the transport mechanisms of water and fluorine but requires a thorough understanding of its elastic properties. The influence of OH content on elastic constants of topaz has not been fully understood, though experimental and theoretical studies have been done on topaz with various OH contents. We thus determined elastic constants of topaz for five natural single-crystal specimens with different OH contents (x = 0.28~0.72) via the sphere resonance method at an ambient condition. Our determined C11, C22, C44, C66, C12, C23, and C31 increase with OH content while C33 and C55 decrease. For the change in OH molar content from 0.0 to 1.0, relatively large changes (&gt;3.0%) are seen in C33 [8.0(6)%], C55 [4.9(6)%], and C22 [3.1(7)%]. The OH content dependence of elastic constants is qualitatively similar to that of theoretically determined values except for C11. The theoretical value of C11 decreases as the OH molar content increases from 0.0 to 1.0, whereas the experimental value of C11 slightly increases. Our elastic constants are significantly higher (&gt;3%) than theoretically determined values, especially in diagonal components (Cii). The theoretical lower values must be related to the used lattice parameters, which are systematically larger than the measured lattice parameters. The theoretical approach should be modified to reproduce measured lattice parameters and lead to the agreement of theoretical and experimental elastic constants. Our results provide a clue to a better understanding of the elasticity of topaz and a basis for the seismological detection of subducted oceanic sediments.
Efektivitas Daylight Mirror Shaft sebagai Sistem Pencahayaan Alami Ruang Bawah Tanah pada Langit Tropis
Authors: Margono Seline Adella , Pangestu Mira Dewi 
Published: December 2021

Title: Effectiveness of Daylight Mirror Shafts as Natural Daylighting System for Basements under Tropic Sky Conditions

Basements have lots of potential as functional spaces, but have mostly been neglected due to lighting issues. Therefore, this study will explore the daylight mirror shaft system as a daylight strategy for basements, which features the placement of a reflecting surface on a light shaft to redirect daylight. The system was introduced by Heliobus®, a daylighting company from Switzerland. To see the effectiveness of implementing the system in Indonesia, a study was made on its performance on the climate sky condition. Furthermore, a study was made on the effect of different opening orientations and light shaft placements toward the illuminance level achieved. The lighting data was obtained using the simulation softwares Lightstanza. Results show that the performance of the system on climate sky condition can provide sufficient light for 41% of a basement. The use of mirrors on the light shaft could also increase the lighting levels by 2.1 times compared to a shaft without a mirror. Moreover, it was found that different opening orientations and light shaft placements didn’t give a significant effect on the lighting quantity. Overall, the study shows that the system’s implementation on climate skies still require adjustments through further studies to be effective.