bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Protective Tidal Volume Adapted To Lung Compliance and The PEEP Level With Lowest Transpulmonary Driving Pressure May Be Determined By a Rapid PEEP-Step Procedure
Authors: Grivans Christina , Stenqvist Ola 
Published: August 2021

Abstract
Background: A protective ventilation strategy should be based on lung mechanics and transpulmonary pressure, as this is the pressure that directly “hits” the lung. Esophageal pressure has been used for this purpose but has not gained widespread clinical acceptance. Instead, respiratory system mechanics and airway driving pressure have been used as surrogate measures. We have shown that the lung pressure/volume (P/V) curve coincides with the line connecting the end-expiratory airway P/V points of a PEEP trial. Consequently, transpulmonary pressure increases as much as PEEP and lung compliance (CL) can be determined as ΔEELV/ΔPEEP and transpulmonary driving pressure (ΔPTP) as tidal volume divided by ΔEELV/ΔPEEP.Methods: In ten patients with acute respiratory failure, ΔEELV was measured during each 4 cmH2O PEEP-step from 0 to 16 cmH2O and CL for each PEEP interval calculated as ΔEELV/ΔPEEP giving a lung P/V curve for the whole PEEP trial. Similarily, a lung P/V curve was obtained also for the PEEP levels 8, 12, and 16 cmH2O only.Results: A two-step PEEP procedure starting from a clinical PEEP level of 8 cmH2O gave almost identical lung P/V curves as the four PEEP-step procedure. The lung P/V curves showed a marked individual variation with an over-all CL (CLoa ) 50-137 ml/cmH2O. ΔPTP of a tidal volume of 6-7 ml/kg ideal body weight divided by CLoa ranged from 8.6-2.8 cmH2O, while ΔPTP of tidal volume adapted to CLoa ranged from 3.3 in the patient with lowest to 4.3 cmH 2 O in the patient with highest CLoa . The ratio of airway driving pressure to transpulmonary driving pressure (ΔPTP/ΔPAW) varied between patients and changed with PEEP, reducing the value of ΔPAW as surrogate for ΔPTP in individual patients.Conclusion: Only a two PEEP-step procedure is required for obtaining a lung P/V curve from baseline clinical PEEP to end-inspiration at the highest PEEP level, i.e. without esophageal pressure measurements. The best-fit equation for the curve can be used to determine a tidal volume related to lung compliance instead of ideal body weight and the PEEP level where transpulmonary driving pressure is lowest and possibly least injurious for any given tidal volume.
Predictors of Heart Failure Symptoms in Hereditary Hemorrhagic Telangiectasia Patients With Hepatic Arteriovenous Malformations
Authors: Cusumano Lucas Russell , Tesoriero Joseph A , Wilsen Craig B , Sayre James , Quirk Matthew , McWilliams Justin P 
Published: August 2021

Abstract
BackgroundHepatic arteriovenous malformations (AVMs) in hereditary hemorrhagic telangiectasia (HHT) patients are most commonly hepatic artery to hepatic venous shunts which can result in high-output heart failure. This condition can be debilitating and is a leading cause of liver transplantation in HHT patients. However, it is not known what characteristics can discriminate between asymptomatic patients and those who will develop heart failure symptoms.Results176 patients with HHT were evaluated with computed tomography angiography (CTA) between April 2004 and February 2019 at our HHT Center of Excellence. 63/176 (35.8%) patients were found to have hepatic AVMs on CTA. 18 of these patients were excluded because of the presence of another condition which could confound evaluation of heart failure symptoms. In the remaining 45 patients included in our cohort, 25/45 (55.6%) patients were classified as asymptomatic and 20/45 (44.4%) were classified as symptomatic, and these groups were compared. In symptomatic patients, mean common hepatic artery (CHA) diameter was significantly higher (11.1 versus 8.4 mm) and mean hemoglobin levels were significantly lower (10.7 vs 12.6 g/dL). A stepwise multiple logistic regression analysis demonstrated that both CHA diameter and hemoglobin level were independent predictors of heart failure symptoms with ORs of 2.554 (95% CI 1.372-4.754) and 0.489 (95% CI 0.299-0.799), respectively. The receiver operator characteristic (ROC) curve of our analysis demonstrated an AUC of 0.906 (95% CI 0.816–0.996), sensitivity 80.0% (95% CI 55.7-93.4%), and specificity 75.0% (95% CI 52.9-89.4%).ConclusionsCTA is an effective and easily reproducible method to evaluate hepatic involvement of HHT. Utilizing CTA, clinical, and laboratory data we determined CHA diameter and hemoglobin level were independent predictors of heart failure symptoms.
Acute Diplopia of Non-neurological/restrictive Etiology: a Retrospective Comparative Study.
Authors: Savino Gustavo , Scampoli Alessandra , Piccinni Fabrizio , Mattei Roberta , Salerni Annabella , Crincoli Emanuele 
Published: August 2021

Abstract
PurposeTo describe and compare the clinical features and management of different types of acute diplopia of non-neurological/restrictive etiology.MethodsRetrospective comparative study carried out reviewing medical records of forty-eight patients referred to one tertiary referral center between January 2016 and June 2020.Thirty-two were classified as Acute Acquired Comitant Esotropia (AACE), 3 cases as type I (group A), 12 cases as type II (group B) and 17 cases as type III (group C). Four cases were classified as Decompensated MonoFixation Syndrome (DMFS) (group D), 6 cases as High Myopia-Comitant Esotropia (HMCE) (group E) and 6 cases as Sagging Eye Syndrome (SES) (group F). Patients with diplopia of neurological or restrictive etiology were excluded.All patients underwent a complete orthoptic and ophthalmologic assessment with a postoperative follow-up of 11.4 ± 4.1 months (ranging from 5 to 20 months).ResultsType 3 AACE (Group C) was the most frequent cause of diplopia among the groups (35.4%). High Myopia-Comitant Esotropia (Group E) and Sagging Eye Syndrome (Group F) were significantly older at onset and baseline examination (both P= .001). Constant acute onset was significantly more represented in Group C (P= .026) while all patients in Group F showed an intermittent onset. Near angle of deviation was significantly lower in Group E and Group F compared to Group C (P= .030). A significantly higher near divergence fusion amplitude was detected in Group C (P= .017). Compensation (angle of deviation increasing) at Prism Adaptation Test (PAT) was observed in 75% of total study population, without significant differences among group. Fifty-four % of the total sample underwent surgery as first or secondary treatment choice with good functional results regardless of pathogenesis.ConclusionDemographic characteristics and clinical features (refraction, type of diplopia at onset, angle deviation, fusion amplitudes, response to prismatic correction) can differentiate different types of acute or subacute onset diplopia of not neurological/restrictive etiology.
Theoretical design of high-nitrogen energetic molecules: Performance prediction of pentazole-based derivatives
Authors: Wang Hao-Ran , Zhang Chong , Sun Cheng-Guo , Hu Bing-Cheng , Ju Xue-Hai 
Published: August 2021

Abstract
High nitrogen energetic compounds have always been a hot spot in energetic materials. In this work, we provide a new approach for the design of promising energetic molecules containing pentazole. Attractive energetic compounds include 5-amino-3-nitro-1H-1,2,4-triazole (ANTA) and 5-nitro-1,2,4-triazol-3-one(NTO) are used to effectively combine with pentazole to form a series of pentazole derivatives. Then, the NH2, NO2 or NF2 groups were introduced into the system to further adjust the property. Herein, the structures and densities of designed compounds as well as the heats of formation, detonation properties and impact sensitivities were predicted based on density functional theory (DFT). The results show that all ten designed molecules have excellent densities (1.81 g/cm3 to 1.97 g/cm3) and high heats of formation (621.66 kJ/mol to 1374.63 kJ/mol). Furthermore, detonation performances of compounds A3 (P = 41.16 GPa and D = 9.45 km/s) and A4 (P = 43.90 GPa and D = 9.69 km/s) are superior to 1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX), and lower impact sensitivity than HMX. It exhibited that they could be taken as promising candidates of high-energy density materials. This work provides a worthy way to explore the energetic compounds with excellent performance based on pentazole.
The Rexinoid V-125 Reduces Tumor Growth in Preclinical Models of Breast and Lung Cancer
Authors: Reich Lyndsey A. , Moerland Jessica A. , Leal Ana , Zhang Di , Carapellucci Sarah , Lockwood Beth , Jurutka Peter W. , Marshall Pamela A. , Wagner Carl E. , Liby Karen T. 
Published: August 2021

Abstract
Rexinoids are ligands which activate retinoid X receptors (RXRs), regulating transcription of genes involved in cancer-relevant processes. Rexinoids have anti-neoplastic activity in multiple preclinical studies. Bexarotene, used to treat cutaneous T cell lymphoma, is the only FDA-approved rexinoid. Bexarotene has also been evaluated in clinical trials for lung and metastatic breast cancer, wherein subsets of patients responded despite advanced disease. By modifying structures of known rexinoids, we can improve potency and toxicity. We previously screened a series of novel rexinoids and selected V-125 as the lead based on performance in optimized in vitro assays. To validate our screening paradigm, we tested V-125 in clinically relevant mouse models of breast and lung cancer. V-125 significantly (p < 0.001) increased time to tumor development in the MMTV-Neu breast cancer model. Treatment of established mammary tumors with V-125 significantly (p < 0.05) increased overall survival. In the A/J lung cancer model, V-125 significantly (p < 0.01) decreased number, size, and burden of lung tumors. Although bexarotene elevated triglycerides and cholesterol in these models, V-125 demonstrated an improved safety profile. These studies provide evidence that our screening paradigm predicts novel rexinoid efficacy and suggest that V-125 could be developed into a new cancer therapeutic.
The Surrogate Decision Making Participation Experience of Severe Acute Pancreatitis Patient In ICU: A Phenomenological Research In China
Authors: Fang Ting , Wang Shasha , Zhuang Yiyu , Zhang Xiuwei 
Published: August 2021

Abstract
Background Patients with severe acute pancreatitis mental state，tissues and organs function severely affected, patients themselves unable to effective participation in decision making, they have to rely on their family members to participate in clinical decision making, when the patient was admitted in ICU. However, it is unclear what factors influence the surrogate involved in decision making during anxiety, depression, post-traumatic stress disorder and other adverse psychological reactions.To describe the experiences of ICU patient’s family members with severe acute pancreatitis during decision making process.Methods Husserl’s phenomenology was applied in this study. This study was conducted in a critical care unit of a China tertiary hospital. They used Semi-structured face-to-face interviews with 12 surrogates of people with severe acute pancreatitis patient to explore the influencing factors of decision participation. This study followed the Colaizzi’s phenomenological method guided.Results/Finding Our sample consisted of 12 participants. Data analysis revealed four main themes: (i) ICU family surrogate cognitive self-role, (ii) ICU family surrogate consider of uncertainty, (iii) ICU family surrogate Communication and consulting, (iv) Decision-making attitude of ICU surrogate.Conclusion A framework of 4 themes of decisional involvement of family members of patients with severe acute pancreatitis in the ICU was constructed, and the interrelationship of the 4 themes was revealed. Psychological and somatic experience of the family as an outward expression of participation in decision-making, self-ability cognition is the internal cause of decision-making participation, consulting experience and considering uncertain factors are the external cause of decision-making participation. It is very important for ICU professionals to consider family members' decision-making participation. The suggestion that the family members of ICU patients participate in the intervention plan was initially formed ICU professionals should respect the values of patients' family members, to improve the disease awareness of the patient's family, to improve the support of the medical care system, and to improve Communication and emotional support skills for health care workers.
Comparative Analysis Of Orthologous Mast Cell Chymases Active Sites Using Bioinformatics Tools
Authors: Kiran Jawairia 
Published: August 2021

Abstract
Mast cells, neutrophils, basophils, natural killer cells, and cytotoxic T cells are among the hematopoietic cell lines originating from immune cells. The importance of mammalian mast cells in innate immunity has piqued the scientific community's interest. cytoplasmic granules of mast cells. Histamine, proteoglycans, proteins, and cytokines are examples of compounds (mediators) that produce mast cell cytoplasmic granules. When external stimuli are received, these granules are released, causing degranulation. Mast cells generate a lot of proteases including chymase, tryptase, and type A carboxypeptidase, among other things. The structure of chymase cma1 was unknown in mice, but it shares 74 percent of its human sequence with chymase CMA1, which was used as a reference. The human CMA1 structure was used to establish and interpret the mouse cma1 structure. Significant residues from the active site, such as catalytic triads and binding residues, were examined. The position of a catalytic triad in human CMA1 chymase and mouse cma1 chymase has been discovered to be similar. Val 175 and Val 197, respectively, replaced two Ala 192 and Gly 214 residues in active site binding residues in target, according to active site residue analysis. We may deduce from this substitution that the cleavage specificity of mouse cma1 chymase varies from that of human CMA1 chymase.
Fabrication of chitosan-coated mixed spinel ferrite integrated with graphene oxide (GO) for magnetic extraction of viral RNA for potential detection of SARS-CoV-2
Authors: Singh Vijay , Batoo Khalid Mujasam , Singh Mahavir 
Published: August 2021

Abstract
Genetic variants of the COVID-19 causative virus have been arising and circulating globally. In many countries especially in developing ones with a huge population, vaccination has become one of the major challenges. SARS-CoV-2 variants’ fast transmission rate has upsurge the COVID cases, leading to more stress on health systems. In the current COVID-19 scenario, there is the requirement of more adequate diagnostic approaches to check the COVID-19 spread. Out of many diagnostic approaches, a magnetic nanoparticle-based reverse transcription-polymerase chain reaction could be nontrivial. The use of magnetic nanoparticles to separate nucleic acid of SARS-CoV-2 from the patient samples and applied for detection is an easy and more effective way for COVID-19 patient detection. Herein, the magnetic nanoparticles are synthesized using the sol-gel autocombustion methods and then, successfully coated with biopolymer (chitosan) using ultra-sonication. Chitosan-coated nanoparticles are successfully integrated into the graphene oxide sheets to introduce carboxyl groups. Crystallite size calculation, morphological and magnetic studies of synthesized magnetic nanoparticles, and multifunctional magnetic nanoparticles are done using XRD, SEM, TEM, and VSM respectively. Besides the potentiality of the fabricated nanocomposites in RNA extraction protocol is also discussed with schematic representation.
Role of the Kuroshio Current on the Diurnal Variation of the Early-Summer Meiyu-Baiu Rainband
Authors: Park Hyung-Ju , Kim Kwang-Yul 
Published: August 2021

Abstract
Mechanism of the strong diurnal cycle of precipitation over the Kuroshio Current (KC) during mid-June is investigated, when the climatological location of the Meiyu-Baiu front overlaps the KC. Heating from the KC intensifies in the morning when the temperature difference between the sea surface and the surface air (TDF) maximizes. The diurnal cycle of precipitation, on the other hand, peaks in the afternoon, consistent with previous studies. It is revealed that convective precipitation (CP) due to convective instability is in phase with TDF, whereas large-scale precipitation (LSP) caused by the cross-frontal circulation matures later. Intensified convective instability via enhanced heating from the KC in the morning hours (03–12 LST) increases the mean amount of CP as well as the probability of stronger CP. Surface wind convergence is also strengthened during the morning hours and helps sustain the convection. The diurnal cycle of LSP, which peaks in the afternoon hours (12–15 LST), covaries with the intensity of the Meiyu-Baiu front and the assocaited cross-frontal circulation. The wind convergence and deformation anomalies associated with the intensified thermal heating over the KC during the morning hours intensifies the frontogenesis function, which leads to the maximization of the frontal intensity in the afternoon. The direct contribution of diabatic heating to the frontogenesis is relatively weak.
Resistin Forms A Network With Inflammatory Cytokines And Endothelial Damage Markers And Provides Prognostic And Therapeutic Information For COVID-19
Authors: Ebihara Takeshi , Matsumoto Hisatake , Matsubara Tsunehiro , Togami Yuki , Nakao Shunichiro , Matsuura Hiroshi , Kojima Takashi , Sugihara Fuminori , Okuzaki Daisuke , Hirata Haruhiko , Yamamura Hitoshi , Ogura Hiroshi 
Published: August 2021

Abstract
Background: Resistin increases in septic subjects and is associated with severity and prognosis. Its role in Coronavirus disease 2019 (COVID-19) is unknown. We investigated relationships between resistin and the severity, prognosis and time to wean off mechanical ventilation (MV) in two cohorts.Methods: Plasma resistin was available for 306 mild-to-critical COVID-19 patients on days 1, 4 and 8 from the Massachusetts General Hospital Emergency Department COVID-19 (MGH) cohort public proteomics data. The relationship between resistin and severity (World Health Organization COVID-19 outcomes) and the prognosis were evaluated. A cohort of 62 critical COVID-19 patients (Osaka cohort) was used to evaluate the relationship between resistin on days 1 (day of ICU admission), 2–3, 6–8 and 11–15 and the prognosis and time to wean off MV. Correlations among resistin, inflammatory cytokines and endothelial damage markers were evaluated.Results: In the MGH cohort, day 1 resistin was associated with severity and predicted the prognosis in an ROC analysis (AUC, 0.739; 95% CI, 0.659–0.819). Twenty-eight-day non-survivors showed significantly greater resistin levels than 28-day survivors on days 1, 4 and 8. In the Osaka cohort, a Cox proportional hazards model (time dependent) showed a significant relationship between resistin and time to wean off MV (crude hazard ratio, 0.702 [95% CI, 0.508–0.969]). Resistin formed a network with inflammatory cytokines and endothelial damage markers.Conclusions: Resistin was associated with severity, prognosis and time to wean off MV in COVID-19 patients. Resistin formed a network with inflammatory cytokines and endothelial damage markers, suggesting its contribution to the pathogenesis of COVID-19.
Automated Labeling of Chest X-ray Images using a Quantitative Explainable Atlas-Based AI Model
Authors: Kim Doyun , Chung Joowon , Choi Jongmun , Succi Marc , Conklin John , Longo Maria Gabriela Figueiro , Ackman Jeanne , Little Brent , Petranovic Milena , Kalra Mannudeep , Lev Michael , Do Synho 
Published: August 2021

Abstract
The inability to accurately, efficiently label large, open-access medical imaging datasets limits the widespread implementation of artificial intelligence models in healthcare. There have been few attempts, however, to automate the annotation of such public databases; one approach, for example, focused on labor-intensive, manual labeling of subsets of these datasets to be used to train new models. In this study, we describe a method for standardized, automated labeling based on similarity to a previously validated, explainable AI model (xAI), using an atlas-based approach, for which the user can specify a quantitative threshold for a desired level of accuracy, the “probability-of-similarity” (pSim) metric. We showed that our xAI model, by calculating the pSim values for each feature based on comparison to its training-set derived reference atlas, could automatically label the external datasets to a user-selected, high level of accuracy, equaling or exceeding that of human experts.
Health-Seeking Behaviour Among COVID-19 Cases In Singapore: Does Single or Multiple Physicians Make A Difference?
Authors: Tay Min Zhi , Ang Li Wei , Wei Wycliffe Enli , Lee Vernon JM , Leo Yee-Sin , Toh Matthias Paul HS 
Published: August 2021

Abstract
Background: COVID-19 is a novel pandemic affecting almost all countries leading to lockdowns worldwide. In Singapore, locally-acquired cases emerged after the first wave of imported cases, and these two groups may have different health-seeking behaviour affecting disease transmission. Objective: We investigated differences in health-seeking behaviour between locally-acquired cases and imported cases, and within the locally-acquired cases, those who saw single versus multiple healthcare providers.Methods: We conducted a retrospective study of 258 patients who were diagnosed with COVID-19 from 23 January to 17 March 2020. Variables related to health-seeking behaviour included number of visits prior to hospitalisation, timing of the first visit, duration from symptom onset to admission, and places where the cases had at least one visit.Results: Locally-acquired cases had longer duration from symptoms onset to hospital admission (median 6 days, range 1-30) than imported cases (median 4 days, range 1-13) (p<0.0005). Singapore residents were more likely to have at least one visit to private clinics and/or government-subsidised public clinics than non-residents (84.0% vs. 58.7%, p<0.0005). Among locally-acquired cases, those who sought care from a single provider had fewer visits before their hospital admissions compared with those who went to multiple care providers (median 2 vs. 3, p=0.001).Conclusion: Our study indicates the need to encourage individuals to seek medical attention early on in their patient journey, particularly from their family physician or the same doctor. This in turn, would facilitate early detection and isolation, hence limiting local transmission and enabling better control of the pandemic.
High-quality mesoporous SiO2 nanospheres via a confined jet impingement continuous microchannel reactor
Authors: Chen Qiang , Chen Kai , Yu Feng , Guo Aixia , Zou Siqing , Zhou Mei , Li Jiangwei , Dan Jianming , Li Yongsheng , Dai Bin , Guo Xuhong 
Published: August 2021

Abstract
High surface area mesoporous silica (SiO2) nanospheres has been considered an ideal material for the catalytic, adsorption and drug delivery. However, synthesis of ultra-high specific surface area mesoporous silica nanoparticles with well-defined sphere structure and small particle size (< 200 nm) is still challenging. Here, a two-stream confined jet impingement continuous microchannel reactor is proposed to produce novel mesoporous silica nanospheres (MSNs) with ultra-high specific surface area (SSA) and abundant worm-like meso-porosity. The as-obtained MSNs with worm-like mesoporous structure were produced with average particle diameter of 142 ~ 207 nm, high SSA of 1347 ~ 1854 m2/g, total pore volume of 0.86 ~ 1.23 cm3/g and pore diameter of 2.6 ~ 3.3nm. Moreover, the shear force field in the microchannel reactor on the mesoscopic structure of MSNs was simulated by mesoscopic kinetics. Additionally, MSNs was used as the silicon source to synthesize lithium silicate (Li4SiO4), which enhanced carbon dioxide (CO2) adsorption of 27.18 wt% at 650 ℃.