bluuebunny/crossref_metadata_2025_split huggingface dataset:
Counterterrorism policies in the Middle East and North Africa: A regional perspective
Authors: Mansour-Ille Dina 
Published: December 2021

AbstractThe 9/11 attacks and the “War on Terror” brought terrorism and counterterrorism to the forefront of politics. Today, terrorism remains one of the most serious threats to national and international security. Yet, amid the surge of scholarly and policy interest in terrorism and counterterrorism, the literature on counterterrorism policies and strategies in the Middle East at the local and regional levels is sparse, limited and predominantly Western.The experience of political terrorism and violence in the Middle East throughout the 1980s and 1990s, which led to the introduction of a securitization process and the adoption of counterterrorism measures in the region long before the 9/11 attacks, offers important lessons. This paper takes its point of departure from the definitional conundrum of the concepts of “terrorism” and “(national) security” within the Middle East context. It examines the evolution of the securitization process in the Middle East in response to terrorism, with reference to the experiences of countries in the region. As it analyzes the different counterterrorism models and methods employed, it argues that counterterrorism strategies in much of the Middle East have not been effective and have at times been counterproductive.
Warm Phase of AMV Damps ENSO Through Weakened Thermocline Feedback
Authors: Trascasa‐Castro Paloma , Ruprich‐Robert Yohan , Castruccio Frederic , Maycock Amanda C. 
Published: December 2021

AbstractInteractions between ocean basins affect El Niño–Southern Oscillation (ENSO), altering its impacts on society. Here, we explore the effect of Atlantic Multidecadal Variability (AMV) on ENSO behavior using idealized experiments performed with the NCAR‐CESM1 model. Comparing warm (AMV+) to cold (AMV−) AMV conditions, we find that ENSO sea surface temperature (SST) anomalies are reduced by ∼10% and ENSO precipitation anomalies are shifted to the west during El Niño and east during La Niña. Using the Bjerknes stability index, we attribute the reduction in ENSO variability to a weakened thermocline feedback in boreal autumn. In AMV+, the Walker circulation and trade winds strengthen over the tropical Pacific, increasing the background zonal SST gradient. The background changes shift ENSO anomalies westwards, with wind stress anomalies more confined to the west. We suggest the changes in ENSO‐wind stress decrease the strength of the thermocline feedback in the east, eventually reducing ENSO growth rate.
Origin of Frequency‐Doubling and Shoulder‐Like Magnetic Pulsations in ULF Waves
Authors: Li Li , Zhou Xu‐Zhi , Zong Qiu‐Gang , Chen Xing‐Ran , Liu Ying , Hao Yi‐Xin , Yue Chao , Omura Yoshiharu , Rankin Robert , Fu Sui‐Yan 
Published: December 2021

AbstractWe present Van Allen Probes observations of a long‐lasting ultralow frequency (ULF) wave event with frequency doubling features in the compressional wave component. The azimuthal magnetic field, on the other hand, shows shoulder‐like pulsations characterized by the presence of two bumps between the crests and troughs within each wave cycle. A wavelet analysis suggests that the shoulder‐like pulsations originate from a secondary peak of the wave power at a frequency of three times the dominant wave frequency. Shoulder‐like pulsations have been observed in many ULF wave events with frequency doubling features, although this phenomenon has never been reported or explained. Here, we propose that these features can be caused by monochromatic oscillations of the magnetic flux tubes in a ballooning‐mirror mode structure. Then, a simple model is developed to reproduce these signatures, which also has the potential to yield uneven bumps in shoulder‐like pulsations depending on the spacecraft location.
Long‐Term Morphodynamics of a Coupled Shelf‐Shoreline System Forced by Waves and Tides, a Model Approach
Authors: Nnafie A. , de Swart H. E. , Falqués A. , Calvete D. 
Published: December 2021

AbstractSand ridges, with length scales of several km, are prominent features of the seafloor landscape of many sandy continental shelves. Knowledge about the extent to which these ridges influence the large‐scale (i.e., decadal and kilometer scales) morphodynamic evolution of the adjacent shoreline and vice versa (shelf‐shoreline morphodynamic coupling) is limited. The present work aims at quantifying this coupling by using a coupled nonlinear shelf‐shoreline model forced by tides and different wave conditions. Model results show that the presence of sand ridges on the shelf creates longshore non‐uniform wave patterns, which act as a forcing template for the morphodynamic development of the shoreline. The shelf‐shoreline coupling primarily works one way, meaning that the morphodynamic evolution of the shelf affects the evolution of the shoreline. When wave propagation is predominantly aligned with the long axis of the shelf ridges, the forced shoreline undulations are so prominent, that they affect the shelf morphology (significant two‐way coupling). Moreover, for those waves, the longshore spacing of the ridges is strongly imprinted on the shoreline morphology. Weaker shoreline undulations develop for waves that propagate more across the ridges and the weakest for time‐varying wave conditions with large variability in their angles of propagation. Model results compare fairly well with observations. Physical mechanisms underlying the different morphodynamic responses of the coupled shelf‐shoreline system to different wave conditions are also given.
Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1
Authors: Hu Yiming , Zhang Haohao , Xie Ningxia , Liu Dandan , Jiang Yuhang , Liu Zhi , Ye Deji , Liu Sanhong , Chen Xi , Li Cuifeng , Wang Qi , Huang Xingxu , Liu Yongzhong , Shi Yufang , Zhang Xiaoren 
Published: December 2021

AbstractTumor necrosis factor-α (TNF) is described as a main regulator of cell survival and apoptosis in multiple types of cells, including hepatocytes. Dysregulation in TNF-induced apoptosis is associated with many autoimmune diseases and various liver diseases. Here, we demonstrated a crucial role of Bcl-3, an IκB family member, in regulating TNF-induced hepatic cell death. Specifically, we found that the presence of Bcl-3 promoted TNF-induced cell death in the liver, while Bcl-3 deficiency protected mice against TNF/D-GalN induced hepatoxicity and lethality. Consistently, Bcl-3-depleted hepatic cells exhibited decreased sensitivity to TNF-induced apoptosis when stimulated with TNF/CHX. Mechanistically, the in vitro results showed that Bcl-3 interacted with the deubiquitinase CYLD to synergistically switch the ubiquitination status of RIP1 and facilitate the formation of death-inducing Complex II. This complex further resulted in activation of the caspase cascade to induce apoptosis. By revealing this novel role of Bcl-3 in regulating TNF-induced hepatic cell death, this study provides a potential therapeutic target for liver diseases caused by TNF-related apoptosis.
Production of reactive oxygen species by PuRBOHF is critical for stone cell development in pear fruit
Authors: Wang Xiaoqian , Liu Siqi , Sun Huili , Liu Chunyan , Li Xinyue , Liu Yang , Deguo Lyu  , Du Guodong 
Published: December 2021

AbstractThe production of reactive oxygen species (ROS) by NADPH oxidase, which is also referred to as respiratory burst oxidase homolog (RBOH), affects several processes in plants. However, the role of RBOHs in cell wall lignification is not well understood. In this study, we show thatPuRBOHF, an RBOH isoform, plays an important role in secondary wall formation in pear stone cells. ROS were closely associated with lignin deposition and stone cell formation according to microscopy data. In addition, according to the results of an in situ hybridization analysis, the stage-specific expression ofPuRBOHFwas higher in stone cells than in cells of other flesh tissues. Inhibitors of RBOH activity suppressed ROS accumulation and stone cell lignification in pear fruit. Moreover, transient overexpression ofPuRBOHFcaused significant changes in the amount of ROS and lignin that accumulated in pear fruit and flesh calli. We further showed that PuMYB169 regulatesPuRBOHFexpression, whilePuRBOHF-derived ROS induces the transcription ofPuPOD2andPuLAC2. The findings of this study indicate thatPuRBOHF-mediated ROS production, which is regulated by a lignin-related transcriptional network, is essential for monolignol polymerization and stone cell formation in pear fruit.
Transcriptional regulation of flavonoid biosynthesis in Artemisia annua by AaYABBY5
Authors: Kayani Sadaf-Ilyas , Shen Qian , Rahman Saeed-ur , Fu Xueqing , Li Yongpeng , Wang Chen , Hassani Danial , Tang Kexuan 
Published: December 2021

Abstract
Artemisia annua is a medicinal plant rich in terpenes and flavonoids with useful biological activities such as antioxidant, anticancer, and antimalarial activities. The transcriptional regulation of flavonoid biosynthesis in A. annua has not been well-studied. In this study, we identified a YABBY family transcription factor, AaYABBY5, as a positive regulator of anthocyanin and total flavonoid contents in A. annua. AaYABBY5 was selected based on its similar expression pattern to the phenylalanine ammonia lyase (PAL), chalcone synthase (CHS), chalcone isomerase (CHI), and flavonol synthase (FLS) genes. A transient dual-luciferase assay in Nicotiana bethamiana with the AaYABBY5 effector showed a significant increase in the activity of the downstream LUC gene, with reporters AaPAL, AaCHS, AaCHI, and AaUFGT. The yeast one-hybrid system further confirmed the direct activation of these promoters by AaYABBY5. Gene expression analysis of stably transformed AaYABBY5 overexpression, AaYABBY5 antisense, and control plants revealed a significant increase in the expression of AaPAL, AaCHS, AaCHI, AaFLS, AaFSII, AaLDOX, and AaUFGT in AaYABBY5 overexpression plants. Moreover, their total flavonoid content and anthocyanin content were also found to increase. AaYABBY5 antisense plants showed a significant decrease in the expression of flavonoid biosynthetic genes, as well as a decrease in anthocyanin and total flavonoid contents. In addition, phenotypic analysis revealed deep purple-pigmented stems, an increase in the leaf lamina size, and higher trichome densities in AaYABBY5 overexpression plants. Together, these data proved that AaYABBY5 is a positive regulator of flavonoid biosynthesis in A. annua. Our study provides candidate transcription factors for the improvement of flavonoid concentrations in A. annua and can be further extended to elucidate its mechanism of regulating trichome development.
Trellis for efficient data and task management in the VA Million Veteran Program
Authors: Ross Paul Billing , Song Jina , Tsao Philip S. , Pan Cuiping 
Published: December 2021

AbstractBiomedical studies have become larger in size and yielded large quantities of data, yet efficient data processing remains a challenge. Here we present Trellis, a cloud-based data and task management framework that completely automates the process from data ingestion to result presentation, while tracking data lineage, facilitating information query, and supporting fault-tolerance and scalability. Using a graph database to coordinate the state of the data processing workflows and a scalable microservice architecture to perform bioinformatics tasks, Trellis has enabled efficient variant calling on 100,000 human genomes collected in the VA Million Veteran Program.
Identifying occult bladder outlet obstruction in women with detrusor-underactivity-like urodynamic profiles
Authors: Chow Po-Ming , Hsiao Sheng-Mou , Kuo Hann-Chorng 
Published: December 2021

AbstractVoiding dysfunction can result from detrusor underactivity (DU), bladder outlet obstruction (BOO), or both. Conceptually, women with high-pressure low-flow urodynamic profiles are diagnosed with BOO without DU. However, the possibility of BOO is often neglected in women with DU-like (low-pressure low-flow) urodynamic (UDS) profiles. By reviewing the videourodynamic studies (VUDS) of 1678 women, our study identified the key factors suggesting urodynamic BOO (determined by radiographic evidence of obstruction) in women with DU-like UDS profiles (Pdet.Qmax < 20 cmH2O and Qmax < 15 mL/s). In 355 women with DU-like UDS profiles, there were 70 (19.7%) with BOO and 285 (80.3%) without BOO. The BOO group had predominantly obstructive symptoms. The BOO group showed significantly decreased bladder sensation, lower detrusor pressure (Pdet.Qmax), lower flow rate (Qmax), smaller voided volume, and larger post-voiding residual (PVR) compared to the non-BOO group. In multivariate analysis, volume at first sensation, Qmax, PVR, and detrusor overactivity (DO) remained independent factors for BOO. The receiver operating characteristic (ROC) areas for the parameters were largest for PVR (area = 0.786) and Qmax (area = 0.742). The best cut-off points were 220 mL for PVR and 4 mL/s for Qmax. Our findings provide simple indicators for BOO in women with DU.
Performance and usefulness of a novel automated immunoassay HISCL SARS-CoV-2 Antigen assay kit for the diagnosis of COVID-19
Authors: Saito Kaori , Ai Tomohiko , Kawai Akinori , Matsui Jun , Fukushima Yoshiyuki , Kikukawa Norihiro , Kyoutou Takuya , Chonan Masayoshi , Kawakami Takeaki , Hosaka Yoshie , Misawa Shigeki , Takagi Haruhi , Matsushita Yasushi , Hiki Makoto , Okuzawa Atsushi , Hori Satoshi , Naito Toshio , Miida Takashi , Takahashi Kazuhisa , Tabe Yoko 
Published: December 2021

AbstractHere, we aimed to evaluate the clinical performance of a novel automated immunoassay HISCL SARS-CoV-2 Antigen assay kit designed to detect the nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This kit comprises automated chemiluminescence detection systems. Western blot analysis confirmed that anti-SARS-CoV antibodies detected SARS-CoV-2N proteins. The best cut-off index was determined, and clinical performance was tested using 115 nasopharyngeal swab samples obtained from 46 patients with coronavirus disease 2019 (COVID-19) and 69 individuals who tested negative for COVID-19 through reverse transcription quantitative polymerase chain reaction (RT-qPCR). The HISCL Antigen assay kit showed a sensitivity of 95.4% and 16.6% in samples with copy numbers > 100 and < 99, respectively. The kit did not cross-react with human coronaviruses causing seasonal common cold and influenza, and none of the 69 individuals without COVID-19 were diagnosed with positive results. Importantly, 81.8% of the samples with low virus load (< 50 copy numbers) were diagnosed as negative. Thus, using HISCL antigen assay kits may reduce overdiagnosis compared with RT-qPCR tests. The rapid and high-throughput HISCL SARS-CoV-2 Antigen assay kit developed here proved suitable for screening infectious COVID-19 and may help control the pandemic.
Therapeutic potential of TRPM8 antagonists in prostate cancer
Authors: Di Donato Marzia , Ostacolo Carmine , Giovannelli Pia , Di Sarno Veronica , Monterrey Isabel M. Gomez , Campiglia Pietro , Migliaccio Antimo , Bertamino Alessia , Castoria Gabriella 
Published: December 2021

AbstractTransient receptor potential melastatin-8 (TRPM8) represents an emerging target in prostate cancer, although its mechanism of action remains unclear. Here, we have characterized and investigated the effects of TRPM8 modulators in prostate cancer aggressiveness disclosing the molecular mechanism underlying their biological activity. Patch-clamp and calcium fluorometric assays were used to characterize the synthesized compounds. Androgen-stimulated prostate cancer-derived cells were challenged with the compounds and the DNA synthesis was investigated in a preliminary screening. The most effective compounds were then employed to inhibit the pro-metastatic behavior of in various PC-derived cells, at different degree of malignancy. The effect of the compounds was then assayed in prostate cancer cell-derived 3D model and the molecular targets of selected compounds were lastly identified using transcriptional and non-transcriptional reporter assays. TRPM8 antagonists inhibit the androgen-dependent prostate cancer cell proliferation, migration and invasiveness. They are highly effective in reverting the androgen-induced increase in prostate cancer cell spheroid size. The compounds also revert the proliferation of castrate-resistant prostate cancer cells, provided they express the androgen receptor. In contrast, no effects were recorded in prostate cancer cells devoid of the receptor. Selected antagonists interfere in non-genomic androgen action and abolish the androgen-induced androgen receptor/TRPM8 complex assembly as well as the increase in intracellular calcium levels in prostate cancer cells. Our results shed light in the processes controlling prostate cancer progression and make the transient receptor potential melastatin-8 as a ‘druggable’ target in the androgen receptor-expressing prostate cancers.
Influence of surgical stabilization of clavicle fractures in multiply-injured patients with thoracic trauma
Authors: Eberbach Helge , Lefering Rolf , Hager Sven , Schumm Klaus , Bode Lisa , Jaeger Martin , Maier Dirk , Kalbhenn Johannes , Hammer Thorsten , Schmal Hagen , Bayer Jörg 
Published: December 2021

AbstractThoracic trauma has decisive influence on the outcome of multiply-injured patients and is often associated with clavicle fractures. The affected patients are prone to lung dysfunction and multiple organ failure. A multi-center, retrospective analysis of patient records documented in the TraumaRegister DGU was performed to assess the influence of surgical stabilization of clavicle fractures in patients with thoracic trauma. A total of 3,209 patients were included in the analysis. In 1362 patients (42%) the clavicle fracture was treated operatively after 7.1 ± 5.3 days. Surgically treated patients had a significant reduction in lung failure (p = 0.013, OR = 0.74), multiple organ failure (p = 0.001, OR = 0.64), intubation time (p = 0.004; −1.81 days) and length of hospital stay (p = 0.014; −1.51 days) compared to non-operative treatment. Moreover, surgical fixation of the clavicle within five days following hospital admission significantly reduced the rates of lung failure (p = 0.01, OR = 0.62), multiple organ failure (p = 0.01, OR = 0.59) and length of hospital stay (p = 0.01; −2.1 days). Based on our results, multiply-injured patients with thoracic trauma and concomitant clavicle fracture may benefit significantly from surgical stabilization of a clavicle fracture, especially when surgery is performed within the first five days after hospital admission.
Orthogonal frequency division multiplexing with cascade index modulation
Authors: Hu Zeng , Yang Jing , Guo Pengfei , Li Qiang 
Published: December 2021

AbstractAs an emerging technique, index modulation (IM) can improve the system bit error rate (BER) performance due to the robustness of index bits over conventional modulated symbol bits. The existing IM aided orthogonal frequency division multiplexing (OFDM) schemes only employ one index modulator at the transmitter, which transmits a small amount of index bits in each transmission. In this paper, a novel IM technique, called cascade IM (CIM), is proposed to increase the proportion of the index bits in the transmission by combining the conventional IM with the multiple‐mode IM together. Subcarrier‐wise and subblock‐wise CIM schemes are proposed to achieve different spectral efficiency and diversity order for diverse scenarios in the next generation wireless communication networks. The optimal subcarrier‐wise maximum likelihood detector is proposed for OFDM‐CIM. To reduce the demodulation complexity, a novel tree search based and an iterative log‐likelihood ratio based detectors, which can avoid illegal index patterns in the search process, are developed for OFDM‐CIM. Monte Carlo simulations show that the proposed scheme achieves better BER performance than OFDM‐IM and appears as a competitive candidate of multi‐carrier transmission techniques for next generation wireless communication networks.
Deep reinforcement learning for shared control of mobile robots
Authors: Tian Chong , Shaik Shahil , Wang Yue 
Published: December 2021

AbstractShared control of mobile robots integrates manual input with auxiliary autonomous controllers to improve the overall system performance. However, prior work that seeks to find the optimal shared control ratio needs an accurate human model, which is usually challenging to obtain. In this study, the authors develop an extended Twin Delayed Deep Deterministic Policy Gradient (DDPG) (TD3X)‐based shared control framework that learns to assist a human operator in teleoperating mobile robots optimally. The robot's states, shared control ratio in the previous time step, and human's control input is used as inputs to the reinforcement learning (RL) agent, which then outputs the optimal shared control ratio between human input and autonomous controllers without knowing the human model. Noisy softmax policies are developed to make the TD3X algorithm feasible under the constraint of a shared control ratio. Furthermore, to accelerate the training process and protect the robot, a navigation demonstration policy and a safety guard are developed. A neural network (NN) structure is developed to maintain the correlation of sensor readings among heterogeneous input data and improve the learning speed. In addition, an extended DAGGER (DAGGERX) human agent is developed for training the RL agent to reduce human workload. Robot simulations and experiments with humans in the loop are conducted. The results show that the DAGGERX human agent can simulate real human inputs in the worst‐case scenarios with a mean square error of 0.0039. Compared to the original TD3 agent, the TD3X‐based shared control system decreased the average collision number from 387.3 to 44.4 in a simplistic environment and 394.2 to 171.2 in a more complex environment. The maximum average return increased from 1043 to 1187 with a faster converge speed in the simplistic environment, while the performance is equally good in the complex environment because of the use of an advanced human agent. In the human subject tests, participants' average perceived workload was significantly lower in shared control than that in exclusively manual control (26.90 vs. 40.07, p = 0.013).
Energy‐efficient control of a train considering multi‐trains power flow
Authors: Rao Yu , Feng Xiaoyun , Wang Qingyuan , Sun Pengfei , Xiao Zhuang , Chen Honghui 
Published: December 2021

AbstractFor a selected train journey with multiple trains in the same traction power system, the given driving strategies of other trains can be abstracted as available external power flow. Aims at reducing the energy consumption of the multi‐train system, this paper presents an analytical solution for optimising the selected train trajectory to maximise the utilisation of the external power flow. Specifically, a spatial‐temporal area which combine the track grade along space and the external power over time is constructed and the problem is converted into the energy‐efficient control of a train travels in the spatial‐temporal area. Classical methods of constrained optimisation is used to show that the set of the optimal control modes and the optimal driving speed for the proposed problem are in a state of change. In order to obtain the optimal driving strategy, the spatial‐temporal area is divided into grids, and the evolution of a key adjoint variable when the external power changes is discussed. The authors illustrate our results by finding optimal control sequences and associated speed profile for the freight train in some elementary but realistic examples.