bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationships Between D-Dimer Levels and Stroke Risk as Well as Adverse Clinical Outcomes After Acute Ischemic Stroke or Transient Ischemic Attack: A Systematic Review and Meta-Analysis
Authors: Yuan Bing , Yang Tong , Yan Tao , Cheng Wenke , Bu Xiancong 
Published: June 2021

Objective: Abnormal elevation of D-dimer levels is an important indicator of disseminated intravascular clotting. Therefore, we hypothesized that high D-dimer levels were associated with the risk of stroke and adverse clinical outcomes of patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA).Methods: The present meta-analysis aimed to systematically analyze the associations between D-dimer and the risk of stroke as well as the clinical outcomes of patients with post-stroke or TIA. Meanwhile, dose–response analyses were conducted when there were sufficient data available. Three electronic databases including Pubmed, the Embase database, and the Cochrane Library were searched by two investigators independently. All the pooled results were expressed as risk ratios (RRs).Results: Finally, 22 prospective cohort studies were included into this meta-analysis. The results suggested that high D-dimer levels were associated with increased risks of total stroke (RR 1.4, 95%CI 1.20–1.63), hemorrhagic stroke (RR 1.25, 95%CI 0.69–2.25), and ischemic Stroke (RR 1.55, 95%CI 1.22–1.98), and the dose-dependent relationship was not found upon dose–response analyses. Besides, the high D-dimer levels on admission were correlated with increased risks of all-cause mortality [RR 1.77, 95% confidence interval (CI) 1.26–2.49], 5-day recurrence (RR 2.28, 95%CI 1.32–3.95), and poor functional outcomes (RR 2.01, 95%CI 1.71–2.36) in patients with AIS or TIA.Conclusions: On the whole, high D-dimer levels may be associated with the risks of total stroke and ischemic stroke, but not with hemorrhagic stroke. However, dose–response analyses do not reveal distinct evidence for a dose-dependent association of D-dimer levels with the risk of stroke. Besides, high D-dimer levels on admission may predict adverse clinical outcomes, including all-cause mortality, 5-day recurrence, and 90-day poor functional outcomes, of patients with AIS or TIA. More studies are warranted to quantify the effect of D-dimer levels on the risk of stroke or TIA, so as to verify and substantiate this conclusion in the future.
Post-COVID Opsoclonus Myoclonus Syndrome: A Case Report From Pakistan
Authors: Ishaq Hira , Durrani Talha , Umar Zainab , Khan Nemat , McCombe Pamela , Ul Haq Mian Ayaz 
Published: June 2021

Background: Coronavirus disease-2019 (COVID-19), caused by the severe acute respiratory distress syndrome–coronavirus-2 (SARS-CoV-2), is primarily a respiratory infection but has been recently associated with a variety of neurological symptoms. We present herewith a COVID-19 case manifesting as opsoclonus-myoclonus syndrome (OMS), a rare neurological disorder.Case Presentation: A 63-year-old male diagnosed with COVID-19 infection developed behavioral changes, confusion, and insomnia followed by reduced mobility and abnormal eye movements within 48 h of recovery from respiratory symptoms associated with COVID-19. On examination, he had rapid, chaotic, involuntary saccadic, multidirectional eye movements (opsoclonus), and limb myoclonus together with truncal ataxia. CSF analysis, MRI of the brain, and screening for anti-neuronal and encephalitis related antibodies were negative. Extensive testing revealed no underlying malignancy. The patient was successfully treated with intravenous immunoglobulin (IVIG) with complete resolution of symptoms within 4 weeks of treatment.Conclusion: COVID-19 infection can be associated with the manifestation of opsoclonus myoclonus syndrome, a rare neurological disorder that can be treated with IVIG if not responsive to corticosteroids.
Glucosamine Ameliorates Symptoms of High-Fat Diet-Fed Mice by Reversing Imbalanced Gut Microbiota
Authors: Yuan Xubing , Zheng Junping , Ren Lishi , Jiao Siming , Feng Cui , Du Yuguang , Liu Hongtao 
Published: June 2021

Glucosamine (GlcN) is used as a supplement for arthritis and joint pain and has been proved to have effects on inflammation, cancer, and cardiovascular diseases. However, there are limited studies on the regulatory mechanism of GlcN against glucose and lipid metabolism disorder. In this study, we treated high-fat diet (HFD)-induced diabetic mice with GlcN (1 mg/ml, in drinking water) for five months. The results show that GlcN significantly reduced the fasting blood glucose of HFD-fed mice and improved glucose tolerance. The feces of intestinal contents in mice were analyzed using 16s rDNA sequencing. It was indicated that GlcN reversed the imbalanced gut microbiota in HFD-fed mice. Based on the PICRUSt assay, the signaling pathways of glucolipid metabolism and biosynthesis were changed in mice with HFD feeding. By quantitative real-time PCR (qPCR) and hematoxylin and eosin (H&amp;E) staining, it was demonstrated that GlcN not only inhibited the inflammatory responses of colon and white adipose tissues, but also improved the intestinal barrier damage of HFD-fed mice. Finally, the correlation analysis suggests the most significantly changed intestinal bacteria were positively or negatively related to the occurrence of inflammation in the colon and fat tissues of HFD-fed mice. In summary, our studies provide a theoretical basis for the potential application of GlcN to glucolipid metabolism disorder through the regulation of gut microbiota.
Associations Between Depressive Symptoms and Physical Activity Intensity in an Older Adult Population During COVID-19 Lockdown
Authors: Lage Ana , Carrapatoso Susana , Sampaio de Queiroz Neto Elzier , Gomes Sérgio , Soares-Miranda Luísa , Bohn Lucimere 
Published: June 2021

IntroductionThe COVID-19 pandemic led to the implementation of physical–social distancing measures–including self-isolation, home confinement, and quarantine around the world, with psychological consequences such as depression. Older adults are especially likely to develop depressive symptomatology. This study aims to investigate the association between physical activity intensities and sedentary behavior with depression levels among previously active older adults during the COVID-19 lockdown.MethodsA total of 1,123 physically active older Brazilian adults (67.68 ± 5.91 years, 91.00% female) were interviewed by telephone in regard to sociodemographic, general health status, depression (GDS-15), and physical activity (IPAQ-SV) after being home-confined for 11.59 ± 2.42 weeks. Participants were also asked to self-report changes in their physical activity levels and time spent sitting. Descriptive statistics (mean, frequencies), between-groups comparisons (t-tests and chi-square), and hierarchical regression analysis were used.ResultsAbout 83.80% of older adults self-reported a decrease in daily physical activity levels and 73.90% increased sitting time. Overall, depressive symptoms were observed in 30.40, and 20.80% met physical activity recommendations. Daily moderate (β = −0.174; 95% CI = −0.026; -0.012) and moderate-to-vigorous (β = −0.183; 95% CI = −0.023; 0.011) physical activity intensities were negatively associated with depression score explaining 2.6 and 2.9% of depression variability, respectively, after adjusting for age, gender, education level, body mass index, and polypharmacy. Daily walking and sitting time were not associated with the depression score (p &gt; 0.05).ConclusionThe results provide empiric suggestion supporting moderate to vigorous physical activity as a way to reduce depressive levels among older adults during COVID-19 confinement. Supervised home-based exercise programs, specifically designed for older adults, might be an important strategy to maintain and improve older adults’ mental health.
Decline in Emotional Face Recognition Among Elderly People May Reflect Mild Cognitive Impairment
Authors: Ochi Ryuta , Midorikawa Akira 
Published: June 2021

BackgroundAs with cognitive function, the ability to recognize emotions changes with age. In the literature regarding the relationship between recognition of emotion and cognitive function during aging, the effects of predictors such as aging, emotional state, and cognitive domains on emotion recognition are unclear. This study was performed to clarify the cognitive functions underlying recognition of emotional facial expressions, and to evaluate the effects of depressive mood on recognition of emotion in elderly subjects, as well as to reproduce the effects of aging on the recognition of emotional facial expressions.Materials and MethodsA total of 26 young (mean age = 20.9 years) and 30 elderly subjects (71.6 years) participated in the study. All subjects participated in face perception, face matching, emotion matching, and emotion selection tasks. In addition, elderly subjects were administered a multicomponent cognitive test: the Neurobehavioral Cognitive Status Examination (Cognistat) and the Geriatric Depression Scale-Short Version. We analyzed these factors using multiple linear regression.ResultsThere were no significant differences between the two groups in the face perception task, but in the face matching, emotion matching, and emotion selection tasks, elderly subjects showed significantly poorer performance. Among elderly subjects, multiple regression analyses showed that performance on the emotion matching task was predicted by age, emotional status, and cognitive function, but paradoxical relationships were observed between recognition of emotional faces and some verbal functions. In addition, 47% of elderly participants showed cognitive decline in one or more domains, although all of them had total Cognistat scores above the cutoff.ConclusionIt might be crucial to consider preclinical pathological changes such as mild cognitive impairment when testing for age effects in elderly populations.
Comparison of Patients with Hospital-Recorded Nephrotic Syndrome and Patients with Nephrotic Proteinuria and Hypoalbuminemia: A Nationwide Study in Denmark
Authors: Vestergaard Søren Viborg , Birn Henrik , Hansen Anette Tarp , Nørgaard Mette , Nitsch Dorothea , Christiansen Christian Fynbo 
Published: June 2021

Key Points

Only a minority of patients with the biochemical features of nephrotic syndrome (NS) receive hospital diagnoses specific to NS.Patients identified with hospital-recorded NS are considerably different from those with biochemical features of NS.Laboratory databases should complement hospital databases to fully elucidate the burden of NS and the prognosis of patients with NS.

Background
Registry-based studies of nephrotic syndrome (NS) may only include a subset of patients with biochemical features of NS. To address this, we compared patients with laboratory-recorded nephrotic proteinuria and hypoalbuminemia to patients with hospital-recorded NS.

Methods
We identified adult patients with first-time hospital-recorded NS (inpatients, outpatients, or emergency-room visitors) in the Danish National Patient Registry and compared them with adults with first-time recorded nephrotic proteinuria and hypoalbuminemia in Danish laboratory databases during 2004–2018, defining the date of admission or laboratory findings as the index date. We characterized these cohorts by demographics, comorbidity, medication use, and laboratory and histopathologic findings.

Results
We identified 1139 patients with hospital-recorded NS and 5268 patients with nephrotic proteinuria and hypoalbuminemia; of these, 760 patients were identified in both cohorts. Within 1 year of the first record of nephrotic proteinuria and hypoalbuminemia, 18% had recorded hospital diagnoses indicating the presence of NS, and 87% had diagnoses reflecting any kind of nephropathy. Among patients identified with nephrotic proteinuria and hypoalbuminemia, their most recent eGFR was substantially lower (median of 35 versus 61 ml/min per 1.73 m2), fewer underwent kidney biopsies around the index date (34% versus 61%), and the prevalence of thromboembolic disease (25% versus 17%) and diabetes (39% versus 18%) was higher when compared with patients with hospital-recorded NS.

Conclusions
Patients with nephrotic proteinuria and hypoalbuminemia are five-fold more common than patients with hospital-recorded NS, and they have a lower eGFR and more comorbidities. Selective and incomplete recording of NS may be an important issue when designing and interpreting studies of risks and prognosis of NS.
Ressignificação teórica para a interpretação de um modelo matemático por meio do tempo lógico de Jaques Lacan
Authors: Silva Pontes Edel Alexandre 
Published: June 2021

Decifrar um modelo das coisas perpassa por três circunstâncias observáveis: intuição, deliberação e tomada de decisão. Segundo Jaques Lacan, o tempo lógico é definido em três atos: o instante de ver, o tempo de compreender e o momento de concluir. A interpretação de um modelo matemático segue em três partes analisáveis: a noção intuitiva, o pensamento matemático e a resolução do problema. Este estudo objetivou identificar as verdadeiras relações entre os princípios da descodificação de um modelo da natureza, as etapas de execução do tempo lógico de Lacan e a as fases da explicação de um modelo matemático. A ordem é ressignificar o processo de ensino e aprendizagem de matemática utilizando uma abordagem Lacaniana. Abordagens pedagógicas que fortalecem a intuição e o pensamento matemático são indispensáveis para aprimorar o desenvolvimento metacognitivo do sujeito envolvido.
Development and validation of film stimuli to assess empathy in the work context
Authors: Wieck Cornelia , Scheibe Susanne , Kunzmann Ute 
Published: June 2021

AbstractA growing body of research suggests that empathy predicts important work outcomes, yet limitations in existing measures to assess empathy have been noted. Extending past work on the assessment of empathy, this study introduces a newly developed set of emotion-eliciting film clips that can be used to assess both cognitive (emotion perception) and affective (emotional congruence and sympathy) facets of empathy in vivo. Using the relived emotions paradigm, film protagonists were instructed to think aloud about an autobiographical, emotional event from working life and relive their emotions while being videotaped. Subsequently, protagonists were asked to provide self-reports of the intensity of their emotions during retelling their event. In a first study with 128 employees, who watched the film clips and rated their own as well as the protagonists’ emotions, we found that the film clips are effective in eliciting moderate levels of emotions as well as sympathy in the test taker and can be used to calculate reliable convergence scores of emotion perception and emotional congruence. Using a selected subset of six film clips, a second two-wave study with 99 employees revealed that all facet-specific measures of empathy had moderate-to-high internal consistencies and test–retest reliabilities, and correlated in expected ways with other self-report and test-based empathy tests, cognition, and demographic variables. With these films, we expand the choice of testing materials for empathy in organizational research to cover a larger array of research questions.
Supernova Luminosity Powered by Magnetar–Disk System
Authors: Lin Weili , Wang Xiaofeng , Wang Lingjun , Dai Zigao 
Published: June 2021

Abstract
Magnetars are one of the potential power sources for some energetic supernova explosions such as type I superluminous supernovae (SLSNe I) and broad-lined type Ic supernovae (SNe Ic-BL). In order to explore the possible link between these two subclasses of supernovae (SNe), we study the effect of fallback accretion disk on magnetar evolution and magnetar-powered SNe. In this scenario, the interaction between a magnetar and a fallback accretion disk would accelerate the spin of the magnetar in the accretion regime but could result in substantial spin-down of the magnetars in the propeller regime. Thus, the initial rotation of the magnetar plays a less significant role in the spin evolution. Such a magnetar–disk interaction scenario can explain well the light curves of both SNe Ic-BL and SLSNe I, for which the observed differences are sensitive to the initial magnetic field of the magnetar and the fallback mass and timescale for the disk. Compared to the magnetars powering the SNe Ic-BL, those accounting for more luminous SNe usually maintain faster rotation and have relatively lower effective magnetic fields around peak time. In addition, the association between SLSNe I and long gamma-ray bursts, if observed in the future, could be explained in the context of a magnetar–disk system.
Spacer Length Modification Facilitates Discrimination between Normal and Neoplastic Cells and Provides Clinically Relevant CD37 CAR T Cells
Authors: Okuno Shingo , Adachi Yoshitaka , Terakura Seitaro , Julamanee Jakrawadee , Sakai Toshiyasu , Umemura Koji , Miyao Kotaro , Goto Tatsunori , Murase Atsushi , Shimada Kazuyuki , Nishida Tetsuya , Murata Makoto , Kiyoi Hitoshi 
Published: June 2021

Abstract
Despite the remarkable initial efficacy of CD19 chimeric Ag receptor T (CAR-T) cell therapy, a high incidence of relapse has been observed. To further increase treatment efficacy and reduce the rate of escape of Ag-negative cells, we need to develop CAR-T cells that target other Ags. Given its restricted expression pattern, CD37 was considered a preferred novel target for immunotherapy in hematopoietic malignancies. Therefore, we designed a CD37-targeting CAR-T (CD37CAR-T) using the single-chain variable fragment of a humanized anti-CD37 Ab, transmembrane and intracellular domains of CD28, and CD3ζ signaling domains. High levels of CD37 expression were confirmed in B cells from human peripheral blood and bone marrow B cell precursors at late developmental stages; by contrast, more limited expression of CD37 was observed in early precursor B cells. Furthermore, we found that human CD37CAR-T cells with longer spacer lengths exhibited high gene transduction efficacy but reduced capacity to proliferate; this may be due to overactivation and fratricide. Spacer length optimization resulted in a modest transduction efficiency together with robust capacity to proliferate. CD37CAR-T cells with optimized spacer length efficiently targeted various CD37+ human tumor cell lines but had no impact on normal leukocytes both in vitro and in vivo. CD37CAR-T cells effectively eradicated Raji cells in xenograft model. Collectively, these results suggested that spacer-optimized CD37CAR-T cells could target CD37-high neoplastic B cells both in vitro and in vivo, with only limited interactions with their normal leukocyte lineages, thereby providing an additional promising therapeutic intervention for patients with B cell malignancies.
Study of Obstructive Sleep Apnea Parameters in Patients of Nasal Polyposis Using Peripheral Arterial Tonometry
Authors: Basak Rajat , Rai Devinder , Munjal Manish 
Published: June 2021

Background:
Obstructive sleep apnea (OSA) syndrome is characterized by partial or complete cessation of airflow and oxygen desaturation during sleep owing to upper airway collapse. This study assesses the OSA parameters in nasal polyposis patients before and after functional endoscopic sinus surgery (FESS) with the help of peripheral arterial tonometry (PAT) device.

Methodology:
This was a prospective study done in the months of April 2015 to June 2016. Patients with bilateral nasal polyps with Lund Mackay Scoring marking equal to and more than two of both sides. Thirty patients willing to undergo PAT sleep study before and after FESS were recruited. The sleep parameters thus obtained in the pre- and postoperative period were analyzed.

Results:
Out of 30 patients, 22 patients were male and eight patients were female. The mean age was 43.17 with standard deviation of 10.06 years. The mean body mass index was 29.12 with a standard deviation of 5.76. All patients underwent FESS. The PAT study was done before and after surgery. Snoring grading and Epworth Sleepiness Scale scoring improved in the majority of patients after surgery. The mean respiratory disturbance index (RDI) in the preoperative period was 32.7 which decreased to 11.34 in the postoperative period. The mean apnea hypopnea index (AHI) in the preoperative period was 22.85 which decreased to 6.34 in the postoperative period. The mean oxygen desaturation index (ODI) in the preoperative period was 16.8 which decreased to 4.4 after surgery. Significant correlation (P < 0.001) was found between pre- and postoperative RDI, AHI, ODI, and oxygen desaturation events.

Conclusion:
The OSA parameters before and after endoscopic sinus surgery in nasal polyposis patients got improved. The PAT device, which is the newest novel plethysmograph, proved to be a reliable device for the assessment of sleep apnea parameters in nasal polyposis in the pre- or postoperative period.
Use of herbal medicine during pregnancy and attitudes of pregnant women in Jos, Nigeria
Authors: Dafam Dalen G. , Denou Adama , Idoko Agnes , Jimam Nanloh S. , Okwori Victoria A. , Ohemu Temitayo L. , Yakubu Thomas P. , David Shakur 
Published: June 2021

Herbal medicines have been used for disease prevention and treatment for both humans and animals worldwide. The present study was designed to determine the herbs used during pregnancy in Jos and to evaluate attitudes of pregnant women. The survey was carried out in antenatal clinics. Information was obtained from pregnant women (17-60 years) through both informal, unstructured conversations and the use of structured questionnaire. Botanical data were focused on the name and part of the herbs or plant used during pregnancy including herbs, herbal preparations and finished products having medicinal properties. In total, 300 pregnant women were enrolled for this study. The respondents were farmers (33.3 %), housewives (26.7%) and students (23.3 %). The most commonly used herbs were, garlic (16.7 %), pawpaw (13.6 %), ginger (13.0 %) and Moringa (8.0 %). Among the parts, bulb was the most used (16.7 %) followed by fruits (14 %). The most common reasons for the use were: herbal medicine is more effective than conventional medicine for some medications (20 %) and more easily accessed than conventional medicine (20 %). Most of the women were advised by family (31.3 %) and believed herbs had fewer side effects. The findings revealed their knowledge on medicinal plants. The women used one or more herbal medicine during pregnancy.
Keywords: Pregnant women; Herbal medicine; Medicinal plants; Jos; Nigeria
Imperforate hymen presenting with massive haematocolpos and acute urinary retention in a teenage girl: A case report
Authors: Mwampagatwa Ipyana H. , Mponda Baraka A. 
Published: June 2021

Imperforate hymen is relatively rare but it is the most frequently encountered obstructive anomaly of the female lower genital tract. The clinical presentation vary significantly from patient to patient depending on the age at diagnosis but in most cases the diagnosis is missed in early childhood and therefore the diagnosis is made after puberty when the patient present with haematocolpos, heamatometra or both. When this happens, the presentation could even be tricky because the patient may presents with unlikely symptoms apart from cryptomenorhoea like, urinary retention or bowel obstruction or both. Here we present a 16 years old girl with imperforate hymen and presented with history of lower abdominal pain and distension associated with acute urinary retention. She was treated by hymenotomy and improved dramatically and was discharge 6th day post operatively. This case report is presented to address to clinicians the possibility of imperforate hymen with haematocolpos as a differential diagnosis in adolescent girls particularly those who have not started having their menses in their teens and present with acute urinary retention so that their external genitalia are carefully examined to exclude the possibility of imperforate hymen as a cause of acute urinary retention due to the haematocolpos.