bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jesus and Abba in Gethsemane: A Center in Filial Cooperation
Authors: Moser Paul K. 
Published: May 2021

ABSTRACT
What motivated and empowered Jesus to go, willingly, to Jerusalem to undergo suffering and death? He could have chosen to avoid the fatal confrontation in Jerusalem, but he intended to endure it, despite its tragic end. This situation calls for an explanation in terms of what empowered him in carrying out his intention while facing suffering and death. Such an explanation takes us beyond the periphery to the center of Jesus’s self-understanding and mission. Jesus understood God as “Abba, Father,” in the light of the Hebrew Bible, but he factored in his own experience of God as Abba. This article uses the Gethsemane narrative of the Gospel of Mark to identify Jesus’s Abba relationship, asking whether Jesus’s obedience in Gethsemane was a means to a more basic end rather than an end in itself. We shall see that obedience is not sufficient for this relationship, because obedient actions fall short of a cooperatively responsive filial relationship with God. Cooperative filial responsiveness to God is central to Jesus’s self-understanding. Religious experience of a filial sort plays a key role in the identity of Jesus. In neglecting this experience and the accompanying filial relationship, we fail to understand Jesus and his mission.
Writing History in Renaissance Sicily: The Formation of Sicilian National Identity in the Work of Tommaso Fazello
Authors: Maltempi Anne 
Published: May 2021

Abstract
This study illuminates the process of writing history in Renaissance Sicily. While Italian historians have offered revisionist histories of Sicily in the Medieval period, the same cannot be said for the Sicilian Renaissance. The existing gap in our understanding of Renaissance historiography with regard to Sicily is the result of a much more expansive tradition that can be traced from Dante and Petrarch to later Italian national histories such as those of Francesco DeSanctis and Benedetto Croce, not to mention Jacob Burckhardt. Anglophone historiography of the Renaissance also reflects this trend of overlooking Sicilian historians of this period. We are left with an incomplete understanding of Sicilian history and culture. I offer a different picture of culture in Sicily during this period by examining how humanists of the time wrote Sicilian history and, as a result, constructed Sicilianità, a term I have chosen to discuss the construction of a unique Sicilian national identity. The work of the Dominican friar Tommaso Fazello (1498–1570) is particularly helpful in teasing out the broader pattern in Sicilian intellectual thought of a selective use of history, philosophy, and literature in order to construct Sicilianità.
Frecuencias alélicas y genotípicas del gen Kappa Caseína y βeta Lactoglobulina en ganado Pardo Suizo
Authors: Andrade Ortega Sonaira Gabriela , López Flores Julio Omar , Sánchez Gómez Isaías Ezequiel 
Published: May 2021

La raza Pardo Suizo es una de las razas con gran desarrollo genético orientada a la producción de mayores volúmenes de leche. El objetivo de este estudio fue determinar las frecuencia alélicas y genotípicas del gen de Κappa caseína y βeta Lactoglobulina en ganado con encaste Pardo Suizo y Brahaman. Se seleccionaron 20 hembras bovinas, ubicadas en la finca Santa Rosa de la Facultad de Ciencia Animal de la Universidad Nacional Agraria (UNA). Se extrajo el ADN a partir de sangre total con EDTA. Con la técnica PCR se amplifico fragmentos del gen de Kappa caseína de 351pb y fragmentos de 262pb para el gen Beta lactoglobulina. La genotipificación se realizó con la técnica PCR-FRLP y la separación de fragmentos para ambos genes se realizó en un gel de agarosa al 2 %. Las frecuencias genotípicas encontradas para Κappa caseína fueron de 0.25 (5/20), 0.65 (13/20), 0.10 (2/20), para los genotipos AA, AB y BB respectivamente, resultando más frecuente el heterocigoto AB. Las frecuencias alélicas para este mismo gen fueron de 0.575 y 0.425 para el alelo A y B. Las frecuencias genotípicas para βeta Lactoglobulina fueron 0.05 (1/20), 0.1 (2/20), 0.85 (17/20) para los genotipos AA, AB y BB respectivamente, resultando más frecuente los individuos homocigóticos BB. Las frecuencias alélicas resultaron ser de 0.1 y 0.9 para los alelos A y B de βeta Lactoglobulina. Los individuos evaluados para Κappa caseína presentaron baja proporción del genotipo deseable BB, mientras que para βeta Lactoglobulina la proporción de individuos con genotipo deseable BB fue mayor.
Boron Facilitates Rice Growth, Development, and Related Attributes Under Saline Soil Conditions
Authors: Uddin Md. Rasel , Nuruzzaman Mohammed , Briste Preangka Saha , Islam Md. Morshedul , Bhuiyan Ashik Karim , Joy Md. Istiak Hossain , Ahmed Shakil , Khatun Amena 
Published: May 2021

Abstract
Salinity is a severe environmental threat causing low productivity in field crops. Rice is a staple crop of the world whose yield and quality is highly affected by the salt content in the root zone. Nutrient management, however, is a key factor that can be used to boost rice production in saline soils. Boron (B), a micronutrient with diverse functions, plays a significant role in rice yield. However, little is known about the effects of B under saline conditions on the yield of rice components. ‘Swarna,’ is a local and salt-sensitive rice variety from Bangladesh. A field experiment was conducted in salt-treated soils to assess the possible functions of B for the improvement of ‘Swarna’ yield. The current study showed that B applications substantially improved the length and weight of panicles, number of tillers and grains, seed weight as well as the yield of grain and straw, indicating its role in rice production in saline environments.
HIPEC for Ovarian Cancer: A Controversial Discussion
Authors: Friedrich Michael , Friedrich Dominique , Kraft Clayton , Kuhn Walther , Rogmans Christoph 
Published: May 2021

Peritoneal carcinomatosis is a sign of advanced disease of ovarian cancer. The prognosis of ovarian cancer is significantly improved after cytoreductive surgery with complete tumor debulking followed by platin based chemotherapy. If cytoreductive surgery results in a tumor free situation with remaining tumor less than 0.25 cm, HIPEC may further improve prognosis. Materials and methods: The results of the Krefeld study are presented and the literature is reviewed according to overall survival and progression free survival with or without HIPEC. In the Krefeld study, patients with ovarian cancer and peritoneal carcinomatosis underwent cytoreductive surgery. In patients with optimal tumor debulking, HIPEC was performed. The peri- and postoperative course was observed. Adverse events were recorded after the Clavien-Dindo classification. Results: 43 patients were treated with cytoreductive surgery and HIPEC. In all patients an optimal cytoreductive situation with remaining tumor less than 0.25 cm was achieved. HIPEC was performed with a cisplatin solution (50 mg/m2) at 41°C. The median age of the patients was 56 years (range: 32–74 years), the median peritoneal cancer index (PCI) was 13 (range: 4–21), the median operation time was 356 minutes (range: 192–507 minutes). The median time to postoperative systemic treatment with chemotherapy was 29 days (range 21–70). There was no postoperative surgically associated death. No adverse events were recorded in 16 (37.2%) of 43 patients, no grade III or IV adverse events were reported for 33 (76.7%) patients, and no grade IV adverse events were reported for 41 (95.3%) patients. Grade III adverse events occured in 19 (44.2%) of the 43 patients; a total of 29 grade III adverse events were reported in these 19 patients. Grade IV adverse events occured in 3 (7.0%) of the 43 patients; a total of 3 grade IV adverse events were reported. Two of them resulted in return to the operating room. This was a fistula of the distal small bowel caused by drainage and a revision of wound infection. Conclusion: In ovarian cancer multiple surgical procedures may be necessary in order to have macroscopically eradicated tumor tissue. Combined with HIPEC, this seems to have positive effects on the survival of patients with peritoneal carcinomatosis. Since we have no marked additional adverse events caused by HIPEC in our case series, HIPEC seems to be an additional treatment option of peritoneal carcinomatosis in ovarian cancer. This statement is strengthened by the literature review in that metaanalysis show significant improved OAS and PFS.
Development of LDPE Crystallinity in LDPE/Cu Composites
Authors: Abdelmouleh Makki , Jedidi Ilyes 
Published: May 2021

This chapter summarizes the study of the filler (ie copper) effect on LDPE phasic composition in LDPE/Cu composites prepared in solution. During this research work, a particular effort is focused on the use of DSC under non-standard conditions. Therewith, the presence of copper microparticles has a great effect on the network phase than on the crystalline long-range-order phase of LDPE structure. Furthermore, LDPE phasic composition in absence and presence of copper microparticles is investigated by FTIR spectroscopy followed by a spectral simulation of the band that appeared at 720 cm−1 corresponding to the CH2. Anywise, the two-phase model confirmed that no variation is observed of LDPE phase composition for all copper contents into LDPE/Cu films. However, with the three-phase model the orthorhombic phase fraction was found to be constant compared to the fraction of amorphous and that of network phase were found to increase and decrease respectively with increase in the copper particle load in the film. Overall, the thermal and structural behavior of LDPE in presence of copper particles allows this type to be used as phase change materials (PCMs) by adding a paraffin fraction in the LDPE/Cu composite. An update of the most relevant work carried out in the field of phasic characterization of polyethylene is presented in this chapter.
Pharmacogenomic tests in Oncology - finding the right dose
Authors: Basso Jeziel , Schwartsmann Gilberto 
Published: May 2021

ABSTRACTA pharmacogenetics/genomics (PGx) anticancer drug testing program is being developed by Kurtz and his group at the Brazilian National Cancer Institute (INCA). Drug -gene pairs were selected for PGx testing based on the presence of clinically validated PGx associations and the availability of international guidelines with PGx-informed dosing recommendations. Fluoropyrimidines-DPYD, irinotecan-UGT1A1 and thiopurines-TPMT/NUDT15 were initially included. The current estimation of anticancer therapy doses usually does not reflect the complexities of metabolism. Therefore, efforts should be made in order to refine the ways we prescribe these drugs, being conventional cytotoxic or newer ones. This program is extremely welcome and may lead to more multi-institutional partnerships and should bring a broader discussion on the use of PGx and pharmacokinetics in routine oncology practice.
Real-life data from an oncology infirmary in a Brazilian universitybased teaching hospital
Authors: Silva Pedro Paulo Perroni da , Matos Humberto Pinto De , Buttros Luciana De Araujo Brito , Hatamoto Nadia Yumi , Capassi Ana Clara Salviato , Sales Gabriela Filgueiras , Delgado Gilson Luchezi , Pires Luis Antonio , Borin Julia Villa Rios , Alencar Mateus Sudario , Dias Bruna Carone , Maia Marina Vieira , Carvalho Fernanda Paiva De , Herculano Matheus 
Published: May 2021

ABSTRACT
Objective: Analyze data regarding patients in need of hospital care admitted in our oncology infirmary aiming for better clinical practices, clinical support and scope for financial and structural needs for institutions. Methods: A prospective study of 191 patients admitted for in-hospital care during a year, who were stratified by diagnosis, age, sex, admission reason, duration of stay, re-admission rate and outcomes. Results: 97 male and 94 female patients were admitted, with a 61-year-old mean age; the mean stay was 13,4 days; and a re-admission rate of 9,4%. Main admission causes: terminality [defined by PSECOG=4, with a 30 day or less estimated life expectancy]: 30 patients (15,7%); total pain: 23 (12,0%); oncological emergencies [febrile neutropenia, malignant hypercalcemia, medullar compression, superior vena cava syndrome]: 20 (10,4%); clinical deterioration [defined as worsening of patients performance or malnutrition]: 15 (7,8%); abdominal pain [without acute abdomen]: 14 (7,3%). Most common primary tumor sites were: colorectal=30 (15,7%), breast=28 (14,6%), stomach=20 (10,4%), lung=14 (7,3%), ovary=12 (6,2%) and prostate=10 (5,2%). Results: 99 deaths (mortality rate 52,1%). Patients in terminality presented a 90% ratio of mortality within an average of 6,6 days of hospital care. Febrile neutropenia (42,8%) and abdominal pain (35,7%) both achieved above expected mortality rates. 91 patients were discharged from the hospital and went back to ambulatory care. Conclusion: Our analysis pointed at an admission rate of 1,2%, pointing at good clinical ambulatory practices. The mean in-hospital stay comparison between patients who were discharged and those who died, not considered terminal ill, was unexpectedly similar, 11,7 versus 13,4 days, respectively, suggesting that in-hospital care should be focused on symptoms - not outcomes. Patients with febrile neutropenia and gastrointestinal cancer should be evaluated with caution due to higher than expected mortality rates
EGFR mutation status yield from bronchoalveolar lavage in patients with primary pulmonary adenocarcinoma compared to a venous blood sample and tissue biopsy
Authors: Yanev Nikolay , Mekov Evgeni , Valev Dinko , Yankov Georgi , Milanov Vladimir , Bichev Stoyan , Gabrovska Natalia , Kostadinov Dimitar 
Published: May 2021

Background
In recent years, there has been a revolution in the genomic profiling and molecular typing of lung cancer. A key oncogene is the epidermal growth factor receptor (EGFR). The gold standard for determining EGFR mutation status is tissue biopsy, where a histological specimen is taken by a bronchoscopic or surgical method (transbronchial biopsy, forceps biopsy, etc.). However, in clinical practice the tissue sample is often insufficient for morphological and molecular analysis. Bronchoalveolar lavage is a validated diagnostic method for pathogenic infections in the lower respiratory tract, yet its diagnostic value for oncogenic mutation testing in lung cancer has not been extensively investigated. This study aims to compare the prevalence of EGFR mutation status in bronchoalveolar lavage and peripheral blood referring to the gold standard - tissue biopsy in patients with primary lung adenocarcinoma.

Methods
Twenty-six patients with adenocarcinoma were examined for EGFR mutation from tissue biopsy, peripheral blood sample and bronchoalveolar lavage.

Results
Thirteen patients had wild type EGFR and the other 13 had EGFR mutation. EGFR mutation from a peripheral blood sample was identified in 38.5% (5/13) of patients, whereas EGFR mutation obtained from bronchoalveolar lavage (BAL) was identified in 92.3% (12/13). This study demonstrates that a liquid biopsy sample for EGFR status from BAL has a higher sensitivity compared to a venous blood sample.
Evaluation of Contamination Risks Due to the Sale and Storage Conditions of Smoked, Dried and Fresh Fishes in Ouagadougou
Authors: Ouedraogo Arouna , Zongo Cheikna , Tapsoba François , Cissé Hama , Traoré Yves , Savadogo Aly 
Published: May 2021

Aims: Fish is a product more and more consumed in Burkina Faso, especially in Ouagadougou. Poor sale and storage conditions can impact on the hygienic quality of fish. The objective of this study was to identify the contamination risks due to the sale and storage conditions of smoked, dried and fresh fishes.
Study Design: A descriptive design was used to identify the different types and origins of fish on the markets in Ouagadougou and the practices and conditions of sale that could be sources of chemical and microbiological contamination.
Place and Duration of Study: Relevant data was collated in Ouagadougou (Burkina Faso) from February 2019 to July 2019.
Methodology: A survey was conducted among traders of dried and smoked fish from 50 markets and major sales sites in Ouagadougou. Data collection was done using a questionnaire developed with Sphinx Plus2 software.
Results: The results indicated a higher proportion of men (75%) than women (25%) with an age between 21 and 45 years old were participated in fish trade. The fish encountered in the markets of Ouagadougou come from Sourou, Kompienga and Bagré, as well as from external suppliers such as Côte d'Ivoire, Mali and Senegal. The different types of fish sold were dried or smoked carp (36.67%), smoked catfish (23.33%), dried Nanani or Djêdjê wala (concorde) (13.33%), smoked Macharon (10%), smoked Racok (10%) and smoked eels or Roolgo in mooré (local language) (6.67%). The types of fish most purchased by consumers, in order, were: Carp, Catfish, Macharon, Nanani. In addition, the study detected risks of contamination of the fish, namely: exposure material consisting of tables and baskets, conservation at room temperature, storage period of 10 to 30 days, no training in hygiene, fish served with bare hands, exposed to dust and stray animals.
Conclusion: In sum, the study revealed some characteristics of the fish industry in Ouagadougou and also risks of contamination of fish sold on the markets.
Response of Cabbage (Brassica oleracea var capitata L.) to Organic and Inorganic Fertilizer
Authors: Debrah P. Yaw , Afriyie-Debrah C. , Nuhu F. , Ribeiro P. Francisco , Obeng E. Agyei 
Published: May 2021

Aim: The experiment was conducted in the Kintampo North Municipality during the 2017 cropping season from August to November to evaluate the response of cabbage to different soil amendments.
Methods: It was a single factor experiment laid out in a Randomized Complete Block design with three replications. The five treatments which includes NPK 15-15-15, poultry manure, cow dung and goat manure and a control.
Results: Parameters measured were plant height, number of leaves, leave length, canopy diameter, head diameter and head weight. Generally, all treatments performed better than the control used in the study.
Conclusions: Poultry manure performed similar to NPK 15-15-15, and were superior to all other treatments in all parameters measured. Cow dung and goat manure performed fairly well in the parameters measured.
Recommendation: The study therefore recommends the application of poultry manure for improved growth, yield maximization and sustainable cabbage production. Application of cow dung and goat manure can also be adopted for appreciable yields of cabbage.
Synthesis, Drug Likeness and In-vitro Screening of Some Novel Quinazolinone Derivatives for Anti-Obesity Activity
Authors: Modh Pratik G. , Patel Laxman J. 
Published: May 2021

Aim: A series of novel quinazolinone derivates was synthesized and assessed for their ability to inhibitory action on pancreatic lipase. The cyclization of quinazolinone-4(3H)-one derivatives was achieved, whereas carbon-carbon cross coupling reactions were carried out on cyclized quinazolinone-4(3H)-one. This synthesis method afforded corresponding 2, 3 and 6 substituted quinazolin-4(3H)-ones (3a to 3m) with moderate to high yields.
Methods: Benzamide derivatives (1a-1b) were synthesized from anthranilic acid using acid-amine reaction, followed by cyclization using catalytic p-toluene sulfonic acid and oxidation using (diacetoxyiodo)benzene to give bromo substituted quinazolin-4(3H)-ones (2a-2b), which were cross coupled to suitable boronic acid using Suzuki-Miyaura condition to obtain desired compound (3a-3m). All synthesized compounds were characterized by FTIR, proton NMR, LC-MS analysis, checked for their drug likeness, absorption and evaluated for in vitro pancreatic lipase inhibition activity.
Results: Analytical interpretation of all compounds with infrared, proton NMR and LC-MS spectroscopy confirmed their correct structure. All compounds (3a-3m) show good absorption and have reasonably good molecular properties except 3c and 3m which violate two criteria for Lipinski’s rule. Whereas, Compounds 3l and 3m showed IC50 value of 13.13±0.84 µg/mL and 13.80±1.27 µg/mL respectively comparable to the Orlistat (12.72±0.97µg/mL), a US FDA approved drug for the treatment of obesity.
Conclusion: Pancreatic lipase is an important lipolytic enzyme, synthesized and secreted through pancreas, plays an important role in dietary trigycerol absorption and metabolism. Therefore, reducing fat absorption through pancreatic lipase inhibition is a promising strategy to treat obesity. Based upon our findings, compounds 3l and 3m can be further developed as potent anti-obesity agents.
Reconstruction of Ultra‐thin Alveolar‐capillary Basement Membrane Mimics
Authors: Jain Puja , Nishiguchi Akihiro , Linz Georg , Wessling Matthias , Ludwig Andreas , Rossaint Rolf , Möller Martin , Singh Smriti 
Published: May 2021

AbstractAlveolar‐capillary basement membrane (BM) is ultra‐thin (<2 µm) extracellular matrix that maintains integral epithelial‐endothelial cell layers. In vitro reconstructions of alveolar‐capillary barrier supported on synthetic scaffolds closely resembling the fibrous and ultra‐thin natural BM are essential in mimicking the lung pathophysiology. Although BM topology and dimensions are well known to significantly influence cellular behavior, conventionally used BM mimics fail to recreate this natural niche. To overcome this, electrospun ultra‐thin 2 µm poly(caprolactone) (PCL) nanofibrous mesh is used to establish an alveolar‐capillary barrier model of lung endothelial/epithelial cells. Transepithelial electrical resistance (TEER) and permeability studies reveal integral tight junctions and improved mass transport through the highly porous PCL meshes compared to conventional dense membranes with etched pores. The chemotaxis of neutrophils is shown across the barrier in presence of inflammatory response that is naturally impeded in confined regions. Conventional requirement of 3 µm or larger pore size can lead to barrier disruption due to epithelial/endothelial cell invasion. Despite high porosity, the interconnected BM mimic prevents barrier disruption and allows neutrophil transmigration, thereby demonstrating the physiological relevance of the thin nanofibrous meshes. It is envisioned that these bipolar cultured barriers would contribute to an organ‐level in vitro model for pathological disease, environmental pollutants, and nanotoxicology.
Integrating Bayesian Inference with Scanning Probe Experiments for Robust Identification of Surface Adsorbate Configurations
Authors: Järvi Jari , Alldritt Benjamin , Krejčí Ondřej , Todorović Milica , Liljeroth Peter , Rinke Patrick 
Published: May 2021

AbstractControlling the properties of organic/inorganic materials requires detailed knowledge of their molecular adsorption geometries. This is often unattainable, even with current state‐of‐the‐art tools. Visualizing the structure of complex non‐planar adsorbates with atomic force microscopy (AFM) is challenging, and identifying it computationally is intractable with conventional structure search. In this fresh approach, cross‐disciplinary tools are integrated for a robust and automated identification of 3D adsorbate configurations. Bayesian optimization is employed with first‐principles simulations for accurate and unbiased structure inference of multiple adsorbates. The corresponding AFM simulations then allow fingerprinting adsorbate structures that appear in AFM experimental images. In the instance of bulky (1S)‐camphor adsorbed on the Cu(111) surface, three matching AFM image contrasts are found, which allow correlating experimental image features to distinct cases of molecular adsorption.