bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impaired Insulin Clearance as the Initial Regulator of Obesity-Associated Hyperinsulinemia: Novel Insight Into the Underlying Mechanism Based on Serum Bile Acid Profiles
Authors: Fu Zhenzhen , Wu Qinyi , Guo Wen , Gu Jingyu , Zheng Xuqin , Gong Yingyun , Lu Chenyan , Ye Jingya , Ye Xuan , Jiang Wanzi , Hu Moran , Yu Baowen , Fu Qi , Liu Xiang , Bai Jianling , Li John Zhong , Yang Tao , Zhou Hongwen 
Published: December 2021

OBJECTIVE
To investigate the roles of insulin clearance and insulin secretion in the development of hyperinsulinemia in obese subjects and to reveal the association between insulin clearance and bile acids (BAs).

RESEARCH DESIGN AND METHODS
In cohort 1, insulin secretion, sensitivity, and endogenous insulin clearance were evaluated with an oral glucose tolerance test in 460 recruited participants. In cohort 2, 81 participants underwent an intravenous glucose tolerance test and a hyperinsulinemic-euglycemic clamp to assess insulin secretion, endogenous and exogenous insulin clearance, and insulin sensitivity. Based on insulin resistance levels ranging from mild to severe, obese participants without diabetes were further divided into 10 quantiles in cohort 1 and into tertiles in cohort 2. Forty serum BAs were measured in cohort 2 to examine the association between BAs and insulin clearance.

RESULTS
All obese participants had impaired insulin clearance, and it worsened with additional insulin resistance in obese subjects without diabetes. However, insulin secretion was unchanged from quantile 1 to 3 in cohort 1, and no difference was found in cohort 2. After adjustments for all confounding factors, serum-conjugated BAs, especially glycodeoxycholic acid (GDCA; β = −0.335, P = 0.004) and taurodeoxycholic acid (TDCA; β = −0.333, P = 0.003), were negatively correlated with insulin clearance. The ratio of unconjugated to conjugated BAs (β = 0.335, P = 0.002) was positively correlated with insulin clearance.

CONCLUSIONS
Hyperinsulinemia in obese subjects might be primarily induced by decreased insulin clearance rather than increased insulin secretion. Changes in circulating conjugated BAs, especially GDCA and TDCA, might play an important role in regulating insulin clearance.
The Information Service in Developing the Students’ Discipline Associated to the Utilization of School Canteen
Authors: Novialdi Andrian , Prayitno Prayitno , Marjohan Marjohan 
Published: December 2021

This research begins from the condition of students’ discipline associated to the utilization of school canteen. The aim of the research is to obtain an overview regarding the information services provided by the guidance and counseling teachers. The background of the research is about the students’ discipline associated to school canteen, condition and role of school canteen and also the role of guidance and counseling service particularly information service. The research used a descriptive quantitative method. Then, the population was the principal, guidance and counseling teachers, and students in Padang City Vocational School who were selected by using the purposive sampling technique. The research findings are: 1) the condition and role of school stalls according to the opinion of principal are in good category and according to the opinion of guidance and counseling teachers are in good enough category. 2) Students' disciplin in the utilization of school canteen according to the opinion of guidance and counseling teachers are good, meanwhile the student' opinions are good enough category. 3) The implementation of information services associated to the utilization of school canteens according to guidance and counseling teachers and students is in the good category.
PENGEMBANGAN MULTIMEEDIA PEMBELAJARAN INTERAKTIF INSTALASI MOTOR LISTRIK KELAS XI TITL SMK SWASTA DWIWARNA MEDAN
Authors: Pasaribu Horas Karlos , Siagian Sahat 
Published: December 2021

Abstract This research is generally a research that aims to develop learning multimedia. Multimedia learning is very important in the learning process, good learning multimedia is very effective in the teaching and learning process. Researchers try to develop interactive learning multimedia that can be used in the form of interactive CDs, using several software consisting of Adobe Flash CS6, Adobe Photoshop CS5. Aims to make it easier for students to understand the lesson and also make it easier for educators to deliver lessons. Multimedia learning in this study uses the ADDIE model by using five stages in it which was adapted by Sugiyono. The target of this research is the Expert Lecturer at the State University of Medan. Tests on interactive multimedia by media validators, material validators, and user/acceptance validators showed that the resulting learning multimedia was good with a score of 4.33 for material validation, a score of 4.35 for media validation, and a score of 4.29 for user/acceptance validation. . Keywords: Interactive Multimedia Development, Adobe Flash CS6 Software, Electric Motor Installation. AbstrakPenelitian ini secara umum merupakan penelitian yang bertujuan untuk mengembangkan multimedia pembelajaran. Multimedia pembelajaran termasuk hal yang sangat penting dalam proses pembelajaran, multimedia pembelajaran yang baik sangat efektif digunakan dalam proses belajar mengajar. Peneliti mencoba mengembangkan multimedia pembelajaran interaktif yang dapat digunakan dalam bentuk CD interaktif, menggunakan beberapa software yang terdiri dari Adobe Flash CS6, Adobe Photoshop CS5. Bertujuan untuk memudahkan peserta didik dalam memahami pelajaran dan juga memudahkan pendidik dalam menyampaikan pelajaran. Multimedia pembelajaran pada penelitian ini menggunakan model ADDIE denggan menggunakan lima tahap di dalamnya yang diadaptasi oleh Sugiyono. Sasaran penelitian ini adalah Dosen Ahli Universitas Negeri Medan. Pengujian terhadap multimedia interaktif oleh validator media, validator materi, dan validator user/akseptansi menunjukkan bahwa multimedia pembelajaran yang dihasilkan baik dengan skor 4,33 untuk validasi materi, skor 4,35 untuk validasi media, dan skor 4,29 untuk validasi user/akseptansi. Kata kunci: Pengembangan Multimedia Interaktif, Software Adobe Flash CS6, Instalasi Motor Listrik.
PENGEMBANGAN MEDIA PEMBELAJARAN MULTIMEDIA INTERAKTIF LECTORA INSPIRE MATA PELAJARAN PEKERJAAN DASAR ELEKTROMEKANIK
Authors: Rahmi Aprilia , . Baharuddin 
Published: December 2021

AbstrakTujuan dari penelitian ini adalah mengembangkan media pembelajaran yang layak untuk memudahkan guru dan peserta didik dalam proses belajar mengajar. Penelitian ini adalah jenis penelitian pengembangan (Research and Development) dengan model pengembangan 4D yang dikembangkan oleh Thiagaradjan. Model 4D terdiri dari 4 tahap, yaitu: 1) Define (Pendefinisian), 2) Design (Perancangan), 3) Develop (Pengembangan), 4) Disseminate (Penyebaran). Tahap penyebaran (disseminate) tidak dilakukan dikarenakan waktu serta kondisi yang kurang memungkinkan, dan pada tahap pengembangan (develop) tujuan penelitian telah tercapai dimana media pembelajaran yang dikembangkan telah diketahui sejauh mana kelayakannya untuk diterapkan dalam proses pembelajaran. Tingkat kelayakan media pembelajaran diketahui dari hasil validasi oleh ahli materi dan ahli media. Dari validasi yang telah dilakukan, didapatkan bahwa ahli materi memberikan nilai sebesar 4,58 dan ahli media sebesar 4,57 dimana nilai tersebut mencapai indikator kelayakan Sangat Baik. Dengan demikian pengembangan media pembelajaran ini sangat baik dilakukan karena telah diuji kelayakannya oleh para ahli. Kata Kunci: Pengembangan Media Pembelajaran, Model Pengembangan 4D, Lectora Inspire AbstractThe aims of this research is to develop a viable learning medium to facilitate teachers and learners in the teaching and learning process. This research is a type of research development (Research and Development) with a 4D development model developed by Thiagaradjan. The 4D model consists of 4 stages, namely: 1) Define (Defining), 2) Design (Design), 3) Develop (Development), 4) Disseminate (Deployment). The disseminate stage is not carried out due to time and conditions that are less likely, and at the stage of development (develop) research objectives have been achieved where the learning media developed has been known the extent of its feasibility to be applied in the learning process. The level of feasibility of learning media is known from the results of validation by material experts and media experts. From the validation that has been done, it was found that material experts gave a value of 4.58 and media experts of 4.57 where the value reached the excellent eligibility indicator. Thus the development of this learning media is very well done because it has been tested for feasibility by experts. Keywords: Learning Media Development, 4D Development Model, Lectora Inspire
Data Collection and Analysis for the Development of Environmental Resilience Index in Selangor
Authors: Syed Zainal Yussof Sharifah Husna , Asmawi M. Zainora , Ibrahim Illyani , Wan Mohd Rani Wan Nurul Mardhiah 
Published: December 2021

Over the years, population surges resulted in urban sprawl in meeting the needs and demands of the future generation. However, excessive human activities in the environment cause environmental degradation, which affects cities resilience. In addition, the impact of global climate change has significantly affected the local environmental context in many towns. As a result, we experience constant incidences of natural disasters, such as monsoon floods, flash floods and landslides. The absence of a framework to address the resilience level in Selangor may lead to a problematic situation in planning and managing the development concerning the physical contexts, for instance, the location and topographic aspects. Therefore, this paper introduces the research to develop an Environmental Resilience Index (ERI) to measure Malaysia's level of environmental resilience by selecting Selangor as a case study because of the difference in economic activities that could result in different levels of environmental resilience. This paper also explains the general framework and indicator selected for this study by reviewing environmental systems and reviews of past research and established indicators. Though this study uses secondary data as the basis of data collection, data from authorised departments and agencies are gathered to verify the reliability and validity of data essential in the analysis stage. Lastly, this paper elaborates on the methodology of data collection and data analysis with an example by measuring the ERI level for the component of environmental resources for the district of Kuala Selangor. Considering the latest secondary data, the results demonstrate that Selangor has an ERI of moderate level for the component of environmental resources.
Keywords: resilience, environment, index, Kuala Selangor, methodological
Isolation and Characterization Chemical Compounds From N-Hexane Extract of Zodia Leaves (Evodia suaveolens Scheff.)
Authors: Mutakin Mutakin , Yunita Wina , Nikodemus Titi Wirahardja 
Published: December 2021

Zodia (Evodia suaveolens Scheff.) (Rutaceae) is one of Indonesia's native plants, which comes from Papua which is widely used as traditional medicine. Empirically, zodia leaves are used as anti-mosquitoes, dysentery drugs, boiled bark is useful as a reliever for malaria fever, leaf decoction is used as a tonic, and increases stamina. Until now, no investigation has been carried out for the main compounds of the zodia leaf n-hexane extract which have proven activity. Therefore, it was done the isolation and characterization of the main compound in the zodia leaf n-hexane extract (Evodia suaveolens Scheff.). Zodia leaves were extracted with n-hexane using the Soxhlet tool. The n-hexane extract was fractionated using column chromatography with a gradient of n-hexane-chloroform mixture. Isolates were isolated in the form of white needle crystals which were purified by washing with n-hexane. Isolates were characterized by analyzing various UV, IM, 1D and 2D RMI spectrometry data which were confirmed by analyzing the mass spectrum. Based on the results of spectrometric analysis, it is known that the isolate is thought to be a triterpenoid compound, namely neohop-13 (18) -ene-3α-ol.Keywords: Evodia suaveolens, neohop-13(18)-ene-3α-ol, triterpenoide,
Mikrobiota jelitowa a leki. Interakcje wpływające na skuteczność i bezpieczeństwo farmakoterapii
Authors: Nycz Joanna , Zajdel Alicja 
Published: December 2021

Abstrakt
Mikrobiota jelitowa stanowi nieodłączny element organizmu umożliwiający jego prawidłowe funkcjonowanie. Dzięki mikroorganizmom jelitowym możliwa jest stymulacja układu odpornościowego, synteza witamin czy poprawa wchłaniania składników odżywczych. Jednak jej aktywność może również niekorzystnie działać na organizm, m.in. z powodu przetwarzania treści jelitowej. Opisywana w artykule interakcja mikrobiota–lek uwzględnia pozytywny i negatywny wpływ mikroorganizmów jelitowych na farmakoterapię poprzez bezpośrednie i pośrednie oddziaływanie na lek w organizmie. Ze względu na to, że mikrobiom stanowi nieodłączny element organizmu, ingerencja nawet w jego niewielką część może doprowadzić do wystąpienia daleko idących, czasami niespodziewanych skutków. Stąd w celu poprawy skuteczności i bezpieczeństwa farmakoterapii konieczne jest wyjaśnienie mechanizmów oddziaływania mikrobioty na lek w organizmie.
W artykule podsumowano obecną wiedzę na temat biologicznej aktywności mikrobioty jelitowej, a zwłaszcza oddziaływań mikrobiota–leki determinujących skuteczność i bezpieczeństwo farmakoterapii. Wyszukiwanie przeprowadzono we wrześniu 2020 r. w bazach danych PubMed, Scopus, Web of Science, Cochrane Library i powszechnie dostępnej literaturze z użyciem terminów: „mikrobiota jelitowa”, „mikrobiom”, „metabolizm leku”, „interakcje mikrobiota–lek”. W artykule omówiono interakcje między mikrobiotą a lekami m.in. z grupy antybiotyków, inhibitorów pompy protonowej, sulfonamidów, pochodnych kwasu 5-aminosalicylowego, niesteroidowych leków przeciwzapalnych, przeciwnowotworowych, statyn czy metforminą.
The assessment of the relationship between the severity of gingivitis and the glycosylated hemoglobin levels in adolescent and adult patients with type 1 diabetes
Authors: Lipski Jakub , Burchardt Dorota , Duda-Sobczak Anna , Wyganowska-Świątkowska Marzena 
Published: December 2021

Abstrakt

Background
Diabetes and periodontitis belong to the group of civilizational diseases, which are not associated with any specific bacterial or viral infection but with the rapid development of civilization and technological advances that affect comfort and quality of life. Civilizational diseases occur in highly developed and developing societies. Glycosylated hemoglobin A1c (HbA1c) is one of the standard indicators for the assessment of metabolic compensation in diabetes that reflects the risk of disease complications. One of the significant complications of diabetes that manifests in the oral cavity is gingival and periodontal inflammation, which is directly related to increased insulin resistance and worsened diabetes compensation. Factors influencing inflammation are the patient’s age, directly linked with fine motor skills when it comes to cleaning teeth, and patients’ awareness related to cause-and-effect relationship between dental hygiene, gingival and periodontal inflammation, and HbA1c testing during routine check-ups.

Objectives
To compare the relationship between gingival inflammation and metabolic compensation (HbA1c levels), depending on the patient’s age.

Materials and methods
The study involved 100 patients (50 adolescents and 50 adults, 42 M; 58 F) with type 1 diabetes. The study group was divided according to sex and age into 19 male adolescent patients (10–18 years old; mean age 15.5) and 23 male adult patients (19–45 years old; mean age 27.1). The mean duration of diabetes was 7 years in the group of adolescents and 11 years in the group of adults. The HbA1c levels and gingival index (GI) were measured in all patients. The obtained results were statistically analyzed.

Results
By comparing the study groups, higher HbA1c values were reported in the group of adolescents. HbA1c has been shown to correlate with the GI in adolescents and adults. Despite poorer compensation for diabetes (higher HbA1c), GI values were similar in adolescents and adults.
Anomaly Detection Using XGBoost Ensemble of Deep Neural Network Models
Authors: Ikram Sumaiya Thaseen , Cherukuri Aswani Kumar , Poorva Babu , Ushasree Pamidi Sai , Zhang Yishuo , Liu Xiao , Li Gang 
Published: December 2021

Abstract
Intrusion Detection Systems (IDSs) utilise deep learning techniques to identify intrusions with maximum accuracy and reduce false alarm rates. The feature extraction is also automated in these techniques. In this paper, an ensemble of different Deep Neural Network (DNN) models like MultiLayer Perceptron (MLP), BackPropagation Network (BPN) and Long Short Term Memory (LSTM) are stacked to build a robust anomaly detection model. The performance of the ensemble model is analysed on different datasets, namely UNSW-NB15 and a campus generated dataset named VIT_SPARC20. Other types of traffic, namely unencrypted normal traffic, normal encrypted traffic, encrypted and unencrypted malicious traffic, are captured in the VIT_SPARC20 dataset. Encrypted normal and malicious traffic of VIT_SPARC20 is categorised by the deep learning models without decrypting its contents, thus preserving the confidentiality and integrity of the data transmitted. XGBoost integrates the results of each deep learning model to achieve higher accuracy. From experimental analysis, it is inferred that UNSW_ NB results in a maximal accuracy of 99.5%. The performance of VIT_SPARC20 in terms of accuracy, precision and recall are 99.4%. 98% and 97%, respectively.
Fish Diversity and Its Threatened Status of the Dharla River in Bangladesh
Authors: Alam Md. Ashraful , Ara Yeasmin , Parvez Imran , Roy Jayanto Kumar , Khan Macksood Alam 
Published: December 2021

Abstract
Fish diversity of a riverine ecosystem became reduced due to different manmade and natural calamities. This study investigated the present fish biodiversity status of the Dharla River located (25.8103° N, 89.6487° E) in the northern part of Bangladesh from January to December 2018. In this study, the existing fish biodiversity status of the Dharla River was estimated in terms of diversity indices and threatened status (both global and local). Data was collected from the three sampling sites of the river using different fishing gears and three selected fish markets located in the Kurigram district of Bangladesh. A total of 76 fish species were identified belonging to 8 orders, 26 families and 57 genera. The Cyprinidae was the most dominant family represented by 14 species followed by the Danionidae (13 species), Bagridae (8 species) and few minor families. Apart from the indigenous species, nine exotic fish species were also recorded. The Shannon-Weaver diversity (H), Pielous evenness (e) and Margalef richness (D) indices ranged from 3.00 to 3.71, 0.62 to 0.94 and 3.94 to 7.95, respectively. Out of 76 indigenous species, 28 species (37%) were identified as threatened in Bangladesh, which included critically endangered (4), vulnerable (9) and endangered (15) species. Indiscriminate fishing through poisoning and destructive fishing gears were identified as the major threats to fish biodiversity of the Dharla River. Thus, the river serves as considerable support for threatened indigenous fishes. Therefore, necessary steps are needed to stop destructive fishing, establish permanent fish sanctuaries and proper monitoring for maintaining sustainable biodiversity in the Dharla River.
The Limits of Leadership as a Barrier to Quality Assurance in Higher Education in Algeria
Authors: Belimane Wissam , Chahed Amina 
Published: December 2021

AbstractSince 2010, Quality Assurance (QA) has been officially adopted and has become a priority of the Higher Education (HE) system in Algeria. This study is part of this framework and aims to explore the role of leadership in the QA process as perceived by Quality Management Managers (QMRs). It is based on a qualitative approach through interviews with 27 QMRs from different institutions. Content analysis technique was used to analyse data.The results show that QMRs consider the lack of commitment and involvement of institutions’ higher management as a major constraint to the success of quality processes. The study reveals that the main barrier to QA is related to the limitations of institutions’ governance, which do not promote autonomy and effectiveness. The study suggests that two elements seem to be crucial: autonomy andtraining/awarenessof institutions’ higher managers. Those elements are closely linked and could be at the origin of the success or failure of quality mechanisms.
Gene expression levels of DNA methyltransferase enzymes in Shank3-deficient mouse model of autism during early development
Authors: Srancikova Annamaria , Reichova Alexandra , Bacova Zuzana , Bakos Jan 
Published: December 2021

Abstract

Objectives. The balance between DNA methylation and demethylation is crucial for the brain development. Therefore, alterations in the expression of enzymes controlling DNA methylation patterns may contribute to the etiology of neurodevelopmental disorders, including autism. SH3 and multiple ankyrin repeat domains 3 (Shank3)-deficient mice are commonly used as a well-characterized transgenic model to investigate the molecular mechanisms of autistic symptoms. DNA methyltransferases (DNMTs), which modulate several cellular processes in neurodevelopment, are implicated in the pathophysiology of autism. In this study, we aimed to describe the gene expression changes of major Dnmts in the brain of Shank3-deficient mice during early development.

Methods and Results. The Dnmts gene expression was analyzed by qPCR in 5-day-old homo-zygous Shank3-deficient mice. We found significantly lower Dnmt1 and Dnmt3b gene expression levels in the frontal cortex. However, no such changes were observed in the hippocampus. However, significant increase was observed in the expression of Dnmt3a and Dnmt3b genes in the hypothalamus of Shank3-deficient mice.

Conclusions. The present data indicate that abnormalities in the Shank3 gene are accompanied by an altered expression of DNA methylation enzymes in the early brain development stages, therefore, specific epigenetic control mechanisms in autism-relevant models should be more extensively investigated.