bluuebunny/crossref_metadata_2025_split huggingface dataset:
Northern Gannets (Morus bassanus) breeding at their southern limit struggle with prey shortages as a result of warming waters
Authors: d'Entremont Kyle J N , Guzzwell Leanne M , Wilhelm Sabina I , Friesen Vicki L , Davoren Gail K , Walsh Carolyn J , Montevecchi William A 
Published: November 2021

AbstractNorthern Gannet (Morus bassanus) colonies near the species’ southernmost limits are experiencing plateaued or declining population growth and prolonged poor productivity. These trends have been linked to reductions in the availability of the species’ key prey, the Atlantic mackerel (Scomber scombrus). Declines in mackerel availability have been associated with warming ocean temperatures and over-fishing. Here, we assessed the influence of prey availability, abundance, and sea surface temperature (SST) during the breeding season on Northern Gannet reproductive success over a multi-decadal time span at their southernmost colony at Cape St. Mary's, NL, Canada. We demonstrate that warming SST affects reproductive success differently in early vs. late chick-rearing, but that overall, declining mackerel availability (landings and biomass) due to warming SST and over-exploitation has resulted in poor productivity of Northern Gannets at their southernmost limit. Our study is consistent with previous findings in other colonies in Atlantic Canada and France, and contrasts with findings in more northern colonies where mackerel population increases and range expansion are coinciding with gannet population growth. This implies that warming SST is having opposing influences on Northern Gannets and mackerel at the different extremes of the gannets’ breeding range.
Social and demographic correlates of cardiovascular mortality in the Kassena-Nankana districts of Ghana: a verbal post-mortem analysis
Authors: Oduro Abraham R , Francke Jordan , Ansah Patrick , Jackson Elizabeth F , Wak George , Phillips James F , Haykin Leah A , Azongo Daniel , Bawah Ayaga A , Welaga Paul , Hodgson Abraham , Aborigo Raymond , Heller David J 
Published: November 2021

Abstract

Background
The burden of cardiovascular disease (CVD) in Ghana is rising, but details on its epidemiology are scarce. We sought to quantify mortality due to CVD in two districts in rural Ghana using verbal post-mortem (VPM) data.

Methods
We conducted a proportional sub-hazards analysis of 10 232 deaths in the Kassena-Nankana East and West districts from 2005 to 2012, to determine adult mortality attributed to CVD over time. We stratified results by age, gender and socio-economic status (SES), and compared CVD mortality among SES and gender strata over time. A competing risk model estimated the cumulative effect of eliminating CVD from the area.

Results
From 2005 to 2012, CVD mortality more than doubled overall, from 0.51 deaths for every 1000 person-years in 2005 to 1.08 per 1000 person-years in 2012. Mortality peaked in 2008 at 1.23 deaths per 1000 person-years. Increases were comparable in men (2.0) and women (2.3), but greater among the poorest residents (3.3) than the richest (1.3), and among persons aged 55–69 years (2.1) than those aged ≥70 years (1.8). By 2012, male and female CVD mortality was highest in middle-SES persons. We project that eliminating CVD would increase the number of individuals reaching age 73 years from 35% to 40%, adding 1.6 years of life expectancy.

Conclusions
The burden of CVD on overall mortality in the Upper East Region is substantial and markedly increasing. CVD mortality has especially increased in lower-income persons and persons in middle age. Further initiatives for the surveillance and control of CVD in these vulnerable populations are needed.
Prevalence, risk factors and short-term consequences of adverse birth outcomes in Zimbabwean pregnant women: a secondary analysis of a cluster-randomized trial
Authors: Chasekwa Bernard , Ntozini Robert , Church James A , Majo Florence D , Tavengwa Naume , Mutasa Batsirai , Noble Christie , Koyratty Nadia , Maluccio John A , Prendergast Andrew J , Humphrey Jean H , Smith Laura E ,   for the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial Team
Published: November 2021

Abstract

Background
Globally, 15 million children are born preterm each year and 10.7 million are born at term but with low birthweight (&lt;2500 g).

Methods
The Sanitation Hygiene Infant Nutrition Efficacy (SHINE) cluster-randomized trial enrolled 5280 pregnant women between 22 November 2012 and 27 March 2015 to test the impact of improved water supply, sanitation and hygiene, and improved infant feeding, on child growth and anaemia. We conducted a secondary analysis to estimate the prevalence and risk factors of miscarriage, stillbirth, preterm birth, size small for gestational age (SGA), low birthweight (LBW), perinatal mortality, and neonatal mortality, and to estimate the effects of adverse birth outcomes on infant survival and growth.

Results
The prevalence of adverse birth outcomes was: miscarriage: 5.0% [95% confidence interval (CI), 4.4, 5.7]; stillbirth: 2.3% (95% CI 1.9, 2.7); preterm birth: 18.2% (95% CI 16.9, 19.5); SGA: 16.1% (95% CI 15.0, 17.3); LBW: 9.8% (95% CI 9.0, 10.7); and neonatal mortality: 31.4/1000 live births (95% CI 26.7, 36.5). Modifiable risk factors included maternal HIV infection, anaemia, lack of antenatal care and non-institutional delivery. Preterm infants had higher neonatal mortality [risk ratio (RR): 6.1 (95% CI 4.0, 9.2)], post-neonatal infant mortality [hazard ratio (HR): 2.1 (95% CI 1.1, 4.1)] and stunting at 18 months of age [RR: 1.5 (95% CI 1.4, 1.7)] than term infants; 56% of stillbirths and 57% of neonatal deaths were among preterm births.

Conclusions
Neonatal mortality and stillbirth are high in Zimbabwe and appear to be driven by high preterm birth. Interventions for primary prevention of preterm birth and strengthened management of preterm labour and ill and small neonates are required to reduce neonatal mortality in Zimbabwe and other African countries with similar profiles.
Coronavirus Disease 2019 Messenger RNA Vaccine Immunogenicity in Immunosuppressed Individuals
Authors: Collier Ai-ris Y , Yu Jingyou , McMahan Katherine , Liu Jinyan , Atyeo Caroline , Ansel Jessica L , Fricker Zachary P , Pavlakis Martha , Curry Michael P , Jacob-Dolan Catherine , Patel Het , Sellers Daniel , Barrett Julia , Rowe Marjorie , Ahmad Kunza , Gompers Annika , Aguayo Ricardo , Chandrashekar Abishek , Alter Galit , Hacker Michele R , Barouch Dan H 
Published: November 2021

Abstract
Individuals on immunosuppressive (IS) therapy have increased mortality from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and delayed viral clearance may lead to new viral variants. IS therapy reduces antibody responses following coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccination; however, a comprehensive assessment of vaccine immunogenicity is lacking. Here we show that IS therapy reduced neutralizing, binding, and nonneutralizing antibody functions in addition to CD4 and CD8 T-cell interferon-γ responses following COVID-19 mRNA vaccination compared to immunocompetent individuals. Moreover, IS therapy reduced cross-reactivity against SARS-CoV-2 variants. These data suggest that the standard COVID-19 mRNA vaccine regimens will likely not provide optimal protection in immunocompromised individuals.
Immunogenicity of SCB-2019 Coronavirus Disease 2019 Vaccine Compared With 4 Approved Vaccines
Authors: Ambrosino Donna , Han Htay Htay , Hu Branda , Liang Joshua , Clemens Ralf , Johnson Marina , Siber George , Goldblatt David 
Published: November 2021

Abstract
A significant correlation has been shown between the binding antibody responses against original severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and vaccine efficacy of 4 approved coronavirus disease 2019 vaccines. We therefore assessed the immune response against original SARS-CoV-2 elicited by the adjuvanted S-Trimer vaccine, SCB-2019 + CpG/alum, in the same assay and laboratory. Responses to SCB-2019 were comparable or superior for antibody to original and Alpha variant when compared with 4 approved vaccines. The comparison accurately predicted success of the recently reported efficacy trial of SCB-2019 vaccine. Immunogenicity comparisons to original strain and variants of concern should be considered as a basis for authorization of vaccines.
Interaction between a fluoroquinolone derivative and RNAs with a single bulge
Authors: Nagano Konami , Kamimura Takashi , Kawai Gota 
Published: November 2021

Abstract
Interaction analysis between small molecules and RNA as well as structure determination of RNA–small molecule complexes will be the clues to search for compounds that bind to specific mRNA or non-coding RNA in drug discovery. In this study, the RNA-binding ability of a fluoroquinolone derivative, KG022, was examined against single-residue bulge-containing hairpin RNAs as RNA models. Nuclear magnetic resonance analysis indicated that KG022 interacts with the RNAs in the vicinity of the bulge residue, with preferring C and G as the bulge residues. The solution structures of the RNA–KG022 complexes showed that the KG022 binds to the RNAs at the bulge-out regions. Each substituent in KG022 interacts with specific position of RNAs around the bulge-out region probably contributing the specificity of the binding. This work provides a novel member for the RNA-targeted small molecules.
The Theatre of Exhibitions: Czechoslovakia at the International Exhibition in Paris, 1937
Authors: Filipová Marta 
Published: November 2021

Abstract
How can an exhibition designer engage the visitor at a world’s fair who has already spent hours walking around the grounds, visiting other attractions and countless national pavilions? This question drove many theoretical and practical considerations of exhibition design during the interwar period and preoccupied many designers and artists. As a very active participant in world’s fairs at this time, Czechoslovakia established an intricate system of presenting its material production and cultural prowess which included careful design of the exterior of its pavilion as well as its interior. Using the Czechoslovak pavilion at the International Exhibition of Art and Technology in Modern Life in Paris, 1937, as a case study, this article examines how Czech designers developed their own original ideas about exhibition design informed by other disciplines. It offers a reading of exhibition design in parallel with stage design and claims that the two shared many techniques, aimed at attracting audiences. It stresses, on the one hand, the affiliation between the two design areas and on the other, the original contribution of designers from Czechoslovakia to the development of exhibition design as a self-sufficient field in the interwar period.
Global Estimates of Rotavirus Hospitalizations Among Children Below 5 Years in 2019 and Current and Projected Impacts of Rotavirus Vaccination
Authors: Hallowell Benjamin D , Chavers Tyler , Parashar Umesh , Tate Jacqueline E 
Published: November 2021

Abstract

Background
Rotavirus vaccine impact on rotavirus hospitalizations is not well documented globally. We performed a systematic review to estimate the number of rotavirus hospitalizations that (1) occur annually, (2) are currently prevented by rotavirus vaccines, and (3) could be prevented with improved vaccine coverage and universal vaccine introduction.

Methods
We systematically reviewed articles indexed in the PubMed database published from January 1, 2000, to December 31, 2019. We included all primary peer-reviewed studies with rotavirus hospitalization rates for children below 5 years that reported data prior to vaccine introduction, utilized at least one continuous year of data collection, and collected hospitalization data after 2000 using active surveillance. We grouped pre-vaccine country estimates by childhood mortality strata and calculated the median rate among each group. We then assigned the mortality stratum-specific hospitalization rates to each country and calculated the number of rotavirus hospitalizations by country, mortality strata, and World Health Organization region.

Results
Our search strategy identified 4590 manuscripts, of which 32 were included in the final dataset. In 2019, an estimated 1 760 113 (interquartile range [IQR]: 1 422 645-2 925 372) rotavirus hospitalizations occurred globally, with 524 871 (IQR: 415 987-814 835) prevented by rotavirus vaccination. With universal introduction of rotavirus vaccines and increased vaccine coverage, we estimate that an additional 751 609 (IQR: 607 671-1 318 807) rotavirus hospitalizations can be prevented annually.

Conclusions
This analysis highlights the continued burden of rotavirus hospitalizations among children below 5 years. A large, preventable proportion of this burden could be eliminated by expanding introductions to new countries and increasing rotavirus vaccine coverage to levels seen with other childhood vaccinations.
Breeding effects on canopy light attenuation in maize: a retrospective and prospective analysis
Authors: Lacasa Josefina , Ciampitti Ignacio A , Amas Juan I , Curín Facundo , Luque Sergio F , Otegui María E 
Published: November 2021

Abstract
The light attenuation process within a plant canopy defines energy capture and vertical distribution of light and nitrogen (N). The vertical light distribution can be quantitatively described with the extinction coefficient (k), which associates the fraction of intercepted photosynthetically active radiation (fPARi) with the leaf area index (LAI). Lower values of k correspond to upright leaves and homogeneous vertical light distribution, increasing radiation use efficiency (RUE). Yield gains in maize (Zea mays L.) were accompanied by increases in optimum plant density and leaf erectness. Thus, the yield-driven breeding programs and management changes, such as reduced row spacing, selected a more erect leaf habit under different maize production systems (e.g., China and the USA). In this study, data from Argentina revealed that k decreased at a rate of 1.1% year–1 since 1989, regardless of plant density and in agreement with Chinese reports (1.0% year–1 since 1981). A reliable assessment of changes in k over time is critical for predicting (i) modifications in resource use efficiency (e.g. radiation, water, and N), improving estimations derived from crop simulation models; (ii) differences in productivity caused by management practices; and (iii) limitations to further exploit this trait with breeding.
Adequate Antibody Response to COVID-19 Vaccine in Patients with Monoclonal Gammopathies and Light Chain Amyloidosis
Authors: Wu Alan H B , Wang Chia-Ching , Ong Chui Mei , Lynch Kara L 
Published: November 2021

Abstract

Objective
Determine the COVID-19 seroconversion rate for patients with multiple myeloma receiving a COVID-19 vaccine.

Materials and Methods
After 45 patients received their second COVID-19 vaccine dose, their serum IgG antibodies were measured: 22 with monoclonal gammopathy (MG) of unknown significance, 3 with smoldering myeloma, 2 with light chain amyloidosis, and 18 with MG (9 in remission, 6 out of remission, and 3 with free light-chain gammopathy alone). A second serum specimen was retained for 16 patients with MG. Their antibody levels were compared to those of 78 uninfected healthy vaccinated control patients.

Results
Three patients with MG had low antibody levels on blood collected 98, 100, and 113 days after the initial vaccine dose (2 with MG of unknown significance and 1 with hypogammaglobulemia). The other 40 patients with MG (seroconversion rate 93%) and both patients with amyloidosis produced antibodies. Relative to days after vaccination, patients with MG had lower antibody levels than control patients.

Conclusion
After receiving a COVID-19 vaccine, most patients with MG produce anti-SARS-CoV-2 antibodies comparable to levels in uninfected vaccinated healthy control patients.
Using action space clustering to constrain the recent accretion history of Milky Way-like galaxies
Authors: Wu Youjia , Valluri Monica , Panithanpaisal Nondh , Sanderson Robyn E , Freese Katherine , Wetzel Andrew , Sharma Sanjib 
Published: November 2021

ABSTRACT
In the currently favoured cosmological paradigm galaxies form hierarchically through the accretion of satellites. Since a satellite is less massive than the host, its stars occupy a smaller volume in action space. Actions are conserved when the potential of the host halo changes adiabatically, so stars from an accreted satellite would remain clustered in action space as the host evolves. In this paper, we identify recently disrupted accreted satellites in three Milky Way-like disc galaxies from the cosmological baryonic FIRE-2 simulations by tracking satellites through simulation snapshots. We try to recover these satellites by applying the cluster analysis algorithm Enlink to the orbital actions of accreted star particles in the z = 0 snapshot. Even with completely error-free mock data we find that only 35 per cent (14/39) satellites are well recovered while the rest (25/39) are poorly recovered (i.e. either contaminated or split up). Most (10/14 ∼70 per cent) of the well-recovered satellites have infall times &lt;7.1 Gyr ago and total mass &gt;4 × 108M⊙ (stellar mass more than 1.2 × 106 M⊙, although our upper mass limit is likely to be resolution dependent). Since cosmological simulations predict that stellar haloes include a population of in situ stars, we test our ability to recover satellites when the data include 10–50 per cent in situ contamination. We find that most previously well-recovered satellites stay well recovered even with 50 per cent contamination. With the wealth of 6D phase space data becoming available we expect that cluster analysis in action space will be useful in identifying the majority of recently accreted and moderately massive satellites in the Milky Way.
The magnetic field and magnetosphere of Plaskett’s star: a fundamental shift in our understanding of the system
Authors: Grunhut J H , Wade G A , Folsom C P , Neiner C , Kochukhov O , Alecian E , Shultz M , Petit V ,   MiMeS BinaMIcS Collaborations
Published: November 2021

ABSTRACT
Plaskett’s ‘star’ appears to be one of a small number of short-period binary systems known to contain a hot, massive, magnetic star. We combine an extensive spectropolarimetric (Stokes V) data set with archival photometry and spectropolarimetry to establish the essential characteristics of the magnetic field and magnetosphere of the rapidly rotating, broad-line component of the system. We apply least-squares deconvolution (LSD) to infer the longitudinal magnetic field from each Stokes V spectrum. Using the time series of longitudinal field measurements, in combination with CoRoT photometry and equivalent width measurements of magnetospheric spectral lines, we infer the rotation period of the magnetic star to be equal to $1.21551^{+0.00028}_{-0.00034}$ d. Modelling the Stokes V LSD profiles with Zeeman–Doppler Imaging, we produce the first reliable magnetic map of an O-type star. We find a magnetic field that is predominantly dipolar, with an obliquity near 90° and a polar strength of about 850 G. We update the calculations of the theoretical magnetospheric parameters, and in agreement with their predictions we identify clear variability signatures of the H α, H β, and He ii λ4686 lines confirming the presence of a dense centrifugal magnetosphere surrounding the star. Finally, we report a lack of detection of radial velocity (RV) variations of the observed Stokes V profiles, suggesting that historical reports of the large RV variations of the broad-line star’s spectral lines may be spurious. This discovery may motivate a fundamental revision of the historical model of the Plaskett’s star as a near-equal mass O + O binary system.
HIT 2.0: an enhanced platform for Herbal Ingredients' Targets
Authors: Yan Deyu , Zheng Genhui , Wang Caicui , Chen Zikun , Mao Tiantian , Gao Jian , Yan Yu , Chen Xiangyi , Ji Xuejie , Yu Jinyu , Mo Saifeng , Wen Haonan , Han Wenhao , Zhou Mengdi , Wang Yuan , Wang Jun , Tang Kailin , Cao Zhiwei 
Published: November 2021

Abstract
Literature-described targets of herbal ingredients have been explored to facilitate the mechanistic study of herbs, as well as the new drug discovery. Though several databases provided similar information, the majority of them are limited to literatures before 2010 and need to be updated urgently. HIT 2.0 was here constructed as the latest curated dataset focusing on Herbal Ingredients’ Targets covering PubMed literatures 2000–2020. Currently, HIT 2.0 hosts 10 031 compound-target activity pairs with quality indicators between 2208 targets and 1237 ingredients from more than 1250 reputable herbs. The molecular targets cover those genes/proteins being directly/indirectly activated/inhibited, protein binders, and enzymes substrates or products. Also included are those genes regulated under the treatment of individual ingredient. Crosslinks were made to databases of TTD, DrugBank, KEGG, PDB, UniProt, Pfam, NCBI, TCM-ID and others. More importantly, HIT enables automatic Target-mining and My-target curation from daily released PubMed literatures. Thus, users can retrieve and download the latest abstracts containing potential targets for interested compounds, even for those not yet covered in HIT. Further, users can log into ‘My-target’ system, to curate personal target-profiling on line based on retrieved abstracts. HIT can be accessible at http://hit2.badd-cao.net.
The Human Proteoform Atlas: a FAIR community resource for experimentally derived proteoforms
Authors: Hollas Michael A R , Robey Matthew T , Fellers Ryan T , LeDuc Richard D , Thomas Paul M , Kelleher Neil L 
Published: November 2021

AbstractThe Human Proteoform Atlas (HPfA) is a web-based repository of experimentally verified human proteoforms on-line at http://human-proteoform-atlas.org and is a direct descendant of the Consortium of Top-Down Proteomics’ (CTDP) Proteoform Atlas. Proteoforms are the specific forms of protein molecules expressed by our cells and include the unique combination of post-translational modifications (PTMs), alternative splicing and other sources of variation deriving from a specific gene. The HPfA uses a FAIR system to assign persistent identifiers to proteoforms which allows for redundancy calling and tracking from prior and future studies in the growing community of proteoform biology and measurement. The HPfA is organized around open ontologies and enables flexible classification of proteoforms. To achieve this, a public registry of experimentally verified proteoforms was also created. Submission of new proteoforms can be processed through email vianrtdphelp@northwestern.edu, and future iterations of these proteoform atlases will help to organize and assign function to proteoforms, their PTMs and their complexes in the years ahead.
Revealing A-T and G-C Hoogsteen base pairs in stressed protein-bound duplex DNA
Authors: Shi Honglue , Kimsey Isaac J , Gu Stephanie , Liu Hsuan-Fu , Pham Uyen , Schumacher Maria A , Al-Hashimi Hashim M 
Published: November 2021

AbstractWatson–Crick base pairs (bps) are the fundamental unit of genetic information and the building blocks of the DNA double helix. However, A-T and G-C can also form alternative ‘Hoogsteen’ bps, expanding the functional complexity of DNA. We developed ‘Hoog-finder’, which uses structural fingerprints to rapidly screen Hoogsteen bps, which may have been mismodeled as Watson–Crick in crystal structures of protein–DNA complexes. We uncovered 17 Hoogsteen bps, 7 of which were in complex with 6 proteins never before shown to bind Hoogsteen bps. The Hoogsteen bps occur near mismatches, nicks and lesions and some appear to participate in recognition and damage repair. Our results suggest a potentially broad role for Hoogsteen bps in stressed regions of the genome and call for a community-wide effort to identify these bps in current and future crystal structures of DNA and its complexes.