bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal trends of COVID-19 mortality and hospitalisation rates: an observational cohort study from the US Department of Veterans Affairs
Authors: Cai Miao , Bowe Benjamin , Xie Yan , Al-Aly Ziyad 
Published: August 2021

ObjectivesTo investigate the temporal trends of 30-day mortality and hospitalisation in US Veterans with COVID-19 and 30-day mortality in hospitalised veterans with COVID-19 and to decompose the contribution of changes in the underlying characteristics of affected populations to these temporal changes.DesignObservational cohort study.SettingUS Department of Veterans Affairs.Participants49 238 US veterans with a positive COVID-19 test between 20 March 2020 and 19 September 2020; and 9428 US veterans hospitalised with a positive COVID-19 test during the same period.Outcome measures30-day mortality rate and hospitalisation rate.ResultsBetween 20 March 2020 and 19 September 2020 and in COVID-19 positive individuals, 30-day mortality rate dropped by 9.2% from 13.6% to 4.4%; hospitalisation rate dropped by 16.8% from 33.8% to 17.0%. In hospitalised COVID-19 individuals, 30-day mortality rate dropped by 12.7% from 23.5% to 10.8%. Among COVID-19 positive individuals, decomposition analyses suggested that changes in demographic, health and contextual characteristics, COVID-19 testing capacity, and hospital occupancy rates accounted for 40.2% and 33.3% of the decline in 30-day mortality and hospitalisation, respectively. Changes in the underlying characteristics of hospitalised COVID-19 individuals accounted for 29.9% of the decline in 30-day mortality.ConclusionBetween March and September 2020, changes in demographic and health characteristics of people infected with COVID-19 contributed measurably to the substantial decline in 30-day mortality and hospitalisation.
Comparison of a preventive or curative strategy of fluid removal on the weaning of mechanical ventilation: a study protocol for a multicentre randomised open-label parallel-group trial
Authors: Dres Martin , Estellat Candice , Baudel Jean-Luc , Beloncle François , Cousty Julien , Galbois Arnaud , Guérin Laurent , Labbe Vincent , Labro Guylaine , Lebut Jordane , Mira Jean-Paul , Prat Gwenael , Quenot Jean-Pierre , Dessap Armand Mekontso 
Published: August 2021

IntroductionFluid overload is associated with a poor prognosis in the critically ill patients, especially at the time of weaning from mechanical ventilation as it may promote weaning failure from cardiac origin. Some data suggest that early administration of diuretics would shorten the duration of mechanical ventilation. However, this strategy may expose patients to a higher risk of haemodynamic and metabolic complications. Currently, there is no recommendation for the use of diuretics during weaning and there is an equipoise on the timing of their initiation in this context.Methods and analysisThis study is a multicentre randomised controlled trial comparing two strategies of fluid removal during weaning in 13 French intensive care units (ICU). The preventive strategy is initiated systematically when the fluid balance or weight change is positive and the patients have criteria for clinical stability; the curative strategy is initiated only in case of weaning failure documented as of cardiac origin. Four hundred and ten patients will be randomised with a 1:1 ratio. The primary outcome is the duration of weaning from mechanical ventilation, defined as the number of days between randomisation and successful extubation (alive without reintubation nor tracheostomy within the 7 days after extubation) at day 28. Secondary outcomes include daily and cumulated fluid balance, metabolic and haemodynamic complications, ventilator-associated pneumonia, weaning complications, number of ventilator-free days, total duration of mechanical ventilation, the length of stay in ICU and mortality in ICU, in hospital and, at day 28. A subgroup analysis for the primary outcome is planned in patients with kidney injury (Kidney Disease: Improving Global Outcomes class 2 or more) at the time of randomisation.Ethics and disseminationThe study has been approved by the ethics committee (Comité de Protection des Personnes Paris 1) and patients will be included after informed consent. The results will be submitted for publication in peer-reviewed journals.Trial registration numberNCT04050007.Protocol versionV.1; 12 March 2019.
Unmet needs in non-metastatic castration-resistant prostate cancer from the Japanese patient perspective: a discrete choice experiment
Authors: Uemura Hiroji , Matsushima Hisashi , Yokomizo Akira , Kobayashi Kazuki , Arai Gaku , Satoh Takefumi , Grillo Vince , Chen Yirong , Singh Shikha , Ledesma Dianne Athene 
Published: August 2021

ObjectivesWith novel antiandrogen treatments of varying clinical benefits and risks becoming available, this study investigates how patients with castration-resistant prostate cancer (CRPC) value differences in treatment characteristics.DesignCross-sectional observational study.SettingA discrete choice experiment was conducted. Patients chose between two hypothetical non-metastatic CRPC (nmCRPC) treatments defined by six attributes: risk of fatigue, falls or fracture, cognitive impairment, hypertension, rashes as side effects to treatment and extension of time until cancer-related pain occurs.ParticipantsA total of 137 adult male patients with CRPC with no prior experience with chemotherapy and with Eastern Cooperative Oncology Group status 0–1 were recruited. Patients were excluded if they participated in an investigational programme outside of routine clinical practice, had a clinically relevant medical or psychiatric condition, or diagnosis of visceral/other metastases not related to the prostate, or were otherwise deemed ineligible by the referring physician.Primary outcome measuresRelative preference weights and relative importance of the attributes was estimated by hierarchical Bayesian logistic regression.ResultsAmong the treatment attributes, ‘risk of cognitive impairment as a side effect of treatment’ was the most important attribute (relative importance (RI) (95% CI): 27.47% (24.80% to 30.14%)), followed by ‘extension of time until cancer-related pain occurs’ (RI (95% CI): 17.87% (15.49% to 20.25%)) and the ‘risk of falls or fracture’ (RI (95% CI): 15.99% (14.73% to 17.25%)). The ‘risk of hypertension as a side effect of treatment’ (RI (95% CI): 13.77% (12.73% to 14.81%)) had similar RI as ‘risk of rashes as a side effect of treatment’ (RI (95% CI): 13.17% (12.15% to 14.19%)), followed by the ‘risk of fatigue as a side effect of treatment’ (RI (95% CI): 11.74% (10.75% to 12.73%)).ConclusionsPatients consider the risk of cognitive impairment as a side effect of treatment as the most important attribute in nmCRPC, followed by the extension of time until cancer-related pain occurs, and the risk of falls and fracture. These features should be considered in treatment decision making for nmCRPC in Japan.
Pentoxifylline in diabetic kidney disease (VA PTXRx): protocol for a pragmatic randomised controlled trial
Authors: Leehey David J , Carlson Kimberly , Reda Domenic J , Craig Ian , Clise Christina , Conner Todd A , Agarwal Rajiv , Kaufman James S , Anderson Robert J , Lammie Douglas , Huminik Jeffrey , Polzin Linda , McBurney Conor , Huang Grant D , Emanuele Nicholas V 
Published: August 2021

IntroductionDiabetic kidney disease (DKD) is the most frequent cause of end-stage renal disease (ESRD) in the USA and worldwide. Recent experimental and clinical data suggest that the non-specific phosphodiesterase inhibitor pentoxifylline (PTX) may decrease progression of chronic kidney disease. However, a large-scale randomised clinical trial is needed to determine whether PTX can reduce ESRD and death in DKD.Methods and analysisVeterans Affairs (VA) PTXRx is a pragmatic, randomised, placebo-controlled multicentre VA Cooperative Study to test the hypothesis that PTX, when added to usual care, leads to a reduction in the time to ESRD or death in patients with type 2 diabetes with DKD when compared with usual care plus placebo. The study aims to enrol 2510 patients over a 4-year period with an additional up to 5-year follow-up to generate a total of 646 primary events. The primary objective of this study is to compare the time until ESRD or death (all-cause mortality) between participants randomised to PTX or placebo. Secondary endpoints will be: (1) health-related quality of life, (2) time to doubling of serum creatinine, (3) incidence of hospitalisations for congestive heart failure, (4) incidence of a three-point major adverse cardiovascular events composite (cardiovascular death, non-fatal myocardial infarction, non-fatal stroke), (5) incidence of peripheral vascular disease, (6) change in urinary albumin-to-creatinine ratio from baseline to 6 months and (7) rate of annual change in estimated glomerular filtration rate (eGFR) during the study period.Ethics and disseminationThis study was approved by the VA Central Institutional Review Board (cIRB/18-36) and will be conducted in compliance with the Declaration of Helsinki and the Guidelines for Good Clinical Practice. The Hines Cooperative Studies Programme will finalise the study results, which will be published in accordance with the Consolidated Standards of Reporting Trials statement in a peer-reviewed scientific journal.Trial registration numberNCT03625648.
Analysis of outcome of 6-month readmissions after percutaneous left atrial appendage occlusion
Authors: Morita Sae , Malik Aaqib H , Kuno Toshiki , Ando Tomo , Kaul Risheek , Yandrapalli Srikanth , Briasoulis Alexandros 
Published: August 2021

ObjectivePercutaneous left atrial appendage occlusion (LAAO) is an alternative strategy for prevention of thromboembolic events in patients with atrial fibrillation and unsuitable for long-term oral anticoagulation. The study aimed to evaluate the causes and timing of readmissions within 6 months following percutaneous LAAO in a real-world setting.MethodsWe conducted a retrospective cohort study of percutaneous LAAO performed in the USA between January and June of 2016–2018 using the Nationwide Readmissions Database.ResultsOverall, 12 446 patients who underwent LAAO were included in the analyses and 3477 patients (28%) were readmitted within 6 months following the interventions. Readmitted patients were more often women (p=0.001). The index hospitalisation was characterised by longer duration of hospital stay (p<0.001) and complicated with acute kidney injury (p<0.001) among readmitted patients compared with those without readmissions. Readmissions within 6 months following the index intervention were mainly due to heart failure (13%) and gastrointestinal bleeding (12%). Characteristics associated with readmissions due to heart failure included previously known heart failure (HR 2.39; 95% CI 1.70 to 3.37), valvular heart disease (HR 1.39; 95% CI 1.05 to 1.84) and chronic kidney disease (HR 1.42; 95% CI 1.03 to 1.94). Readmissions due to gastrointestinal bleeding were associated with diabetes mellitus (HR 1.78; 95% CI 1.25 to 2.53), chronic kidney disease (HR 1.86; 95% CI 1.23 to 2.81) and previous anaemia (HR 2.41; 95% CI 1.54 to 3.77).ConclusionsAfter percutaneous LAAO, over a quarter of the patients in the USA required rehospitalisation within 6 months, mainly due to heart failure and gastrointestinal bleeding.
Natural history of mental health competence from childhood to adolescence
Authors: O'Connor Meredith , Arnup Sarah J , Mensah Fiona , Olsson Craig , Goldfeld Sharon , Viner Russell M , Hope Steven 
Published: August 2021

BackgroundMental health competence (MHC) involves psychosocial capabilities such as regulating emotions, interacting well with peers and caring for others, and predicts a range of health and social outcomes. This study examines the course of MHC from childhood to adolescence and patterning by gender and disadvantage, in Australian and UK contexts.MethodsData: Longitudinal Study of Australian Children (n=4983) and the Millennium Cohort Study (n=18 296). Measures: A measure capturing key aspects of MHC was derived summing items from the parent-reported Strengths and Difficulties Questionnaire, assessed at 4–5 years, 6–7 years, 10–11 years and 14–15 years. Analysis: Proportions of children with high MHC (scores ≥23 of range 8–24) were estimated by age and country. Random-effects models were used to define MHC trajectories according to baseline MHC and change over time. Sociodemographic patterns were described.ResultsThe prevalence of high MHC steadily increased from 4 years to 15 years (from 13.6% to 15.8% and 20.6% to 26.2% in Australia and the UK, respectively). Examination of trajectories revealed that pathways of some children diverge from this normative MHC progression. For example, 7% and 9% of children in Australia and the UK, respectively, had a low starting point and decreased further in MHC by mid-adolescence. At all ages, and over time, MHC was lower for boys compared with girls and for children from disadvantaged compared with advantaged family backgrounds.ConclusionsApproaches to promoting MHC require a sustained focus from the early years through to adolescence, with more intensive approaches likely needed to support disadvantaged groups and boys.
Tracing X-ray-induced formation of warm dense gold with Boltzmann kinetic equations
Authors: Ziaja Beata , Bekx John Jasper , Masek Martin , Medvedev Nikita , Piekarz Przemyslaw , Saxena Vikrant , Stransky Michal , Toleikis Sven 
Published: August 2021

Abstract
In this paper, we report on the Boltzmann kinetic equation approach adapted for simulations of warm dense matter created by irradiation of bulk gold with intense ultrashort X-ray pulses. X-rays can excite inner-shell electrons, which triggers creation of deep-lying core holes. Their relaxation, especially in heavier elements such as gold (atomic number $$Z= 79$$

Z
=
79

) takes complicated pathways, involving collisional processes, and leading through a large number of active configurations. This number can be so high that solving a set of evolution equations for each configuration becomes computationally inefficient, and another modeling approach should be used instead. Here, we use the earlier introduced ’predominant excitation and relaxation path’ approach. It still uses true atomic configurations but limits their number by restricting material relaxation to a selected set of predominant pathways for material excitation and relaxation. With that, we obtain time-resolved predictions for excitation and relaxation in X-ray irradiated bulk of gold, including the respective change of gold optical properties. We compare the predictions with the available data from high-energy-density experiments. Their good agreement indicates ability of the Boltzmann kinetic equation approach to describe warm dense matter created from high-Z materials after their irradiation with X rays, which can be validated in future experiments.

Graphic Abstract
Camrelizumab plus Famitinib in Patients with Advanced or Metastatic Renal Cell Carcinoma: Data from an Open-label, Multicenter Phase II Basket Study
Authors: Qu Yuan-Yuan , Zhang Hai-Liang , Guo Hongqian , Luo Hong , Zou Qing , Xing Nianzeng , Xia Shujie , Sun Zhongquan , Zhang Xuepei , He Chaohong , Cai Jinling , Zhang Xiao , Wang Quanren , Ye Ding-Wei 
Published: August 2021

AbstractPurpose:Blockade of immune checkpoint and angiogenesis is an effective treatment strategy for advanced or metastatic renal cell carcinoma (RCC). We report the results of camrelizumab plus famitinib in the RCC cohort of an open-label, multicenter, phase II basket study.Patients and Methods:Eligible patients were enrolled to receive camrelizumab (200 mg i.v. every 3 weeks) and famitinib (20 mg orally once daily). Primary endpoint was objective response rate (ORR) per RECIST version 1.1.Results:Totally, 38 patients were recruited, including 13 (34.2%) treatment-naïve and 25 (65.8%) previously treated patients. With a median duration from enrollment to data cutoff of 16.5 months (range, 6.1–20.4), 23 patients achieved a confirmed objective response, and ORR was 60.5% [95% confidence interval (CI), 43.4–76.0]. Responses in 18 (78.3%) responders were still ongoing, and Kaplan–Meier estimated median duration of response had not been reached yet (range, 1.0+–14.8+ months). Median progression-free survival (PFS) was 14.6 months (95% CI, 6.2–not reached). ORR was 84.6% (95% CI, 54.6–98.1) in treatment-naïve patients and 48.0% (95% CI, 27.8–68.7) in pretreated patients; median PFS had not been reached and was 13.4 months (95% CI, 4.1–not reached), respectively. Most common grade 3 or 4 treatment-related adverse events included proteinuria (18.4%), hypertension (18.4%), decreased neutrophil count (13.2%), palmar-plantar erythrodysesthesia syndrome (10.5%), and hypertriglyceridemia (10.5%). No treatment-related deaths occurred, and no new safety signals were observed.Conclusions:Camrelizumab plus famitinib showed potent and enduring antitumor activity in patients with advanced or metastatic RCC, both in treatment-naïve and previously treated population.
A fuzzy rule based approach for islanding detection in grid connected inverter systems
Authors: Ikken Naima , Tariba Nour-Eddine , Bouknadel Abdelhadi , Haddou Ahmed , Omari Hafsa El , Omari Hamid El 
Published: August 2021

<span lang="EN-US">Islanding is when an area of the electrical distribution system is isolated from the electrical system while being powered by distributed generators. An important condition for the interconnection of power plants and distribution systems is the ability of the power plant to detect islands. The presented and proposed method is a combination of best active sandia frequency shift (SFS) method with the intelligent fuzzy logic controller, which has been tested in distributed production using the island detection function. And the choice to improve the method by fuzzy logic control (FLC) is retained, as this process is more effective in decreasing the non-</span><span lang="EN-US">detection zone (NDZ) and in further improving the efficiency of the islanding detection system. This paper proposes a new active islanding detection technique controlled by a fuzzy logic controller, for grid connected photovoltaic (PV) inverters. In addition, the efficiency and performance of the proposed method strategy for islanding detection has been analyzed and tested in the various situations of the network. In addition, the results of the simulations with the <span lang="EN-US">power </span><span lang="EN-US">simulation (</span>PSIM) software will be provided to illustrate the main conclusions and the development of the control. Thus, will be used to show the feasibility and validity of the proposed new algorithm.</span>
An adaptive multi-hop routing with IoT abstraction for minimizing delay-node capacity trade-offs in mobile ad-hoc network
Authors: Chasib Haitham Shiaibth , Salih Saddam Raheem , Al-Ogaili Israa Jaber Khalaf 
Published: August 2021

<span>Delay and node capacity are incompatible mobile ad hoc constraints because of the network's versatility and self-disciplined design. </span><span>It is a challenging problem to maximize the trade-off between the above mobility correlation factors. </span><span>This manuscript proposes an adaptive multi-hop routing (A.M.R.) for mobile ad-hoc network (MANET) to minimize the trade-off by integrating the internet of things (IoT). IoT nodes' smart computing and offloading abilities are extended to ad-hoc nodes to improve routing and transmission. Dor MANET nodes in route exploration, neighbor selection, and data transmission, the beneficial features of IoT include enhanced decision making. The traditional routing protocols use IoT at the time of the neighbor discovery process in updating the routing table and localization. </span><span>The harmonizing technologies with their extended support improve the performance of MANETs has been estimated. The proposed method achieves better throughput (14.16 Mbps), delay (0.118), packet drop (126), and overhead (36 packets) when compared to existing methods.</span>
Preeclampsia Across Pregnancies and Associated Risk Factors: Findings From a High‐Risk US Birth Cohort
Authors: Ogunwole S. Michelle , Mwinnyaa George , Wang Xiaobin , Hong Xiumei , Henderson Janice , Bennett Wendy L. 
Published: August 2021

Background
Preeclampsia increases women's risks for maternal morbidity and future cardiovascular disease. The aim of this study was to identify opportunities for prevention by examining the association between cardiometabolic risk factors and preeclampsia across 2 pregnancies among women in a high‐risk US birth cohort.

Methods and Results
Our sample included 618 women in the Boston Birth Cohort with index and subsequent pregnancy data collected using standard protocols. We conducted log‐binomial univariate regression models to examine the association between preeclampsia in the subsequent pregnancy (defined as incident or recurrent preeclampsia) and cardiometabolic risk factors (ie, obesity, hypertension, diabetes mellitus, preterm birth, low birth weight, and gestational diabetes mellitus) diagnosed before and during the index pregnancy, and between index and subsequent pregnancies. At the subsequent pregnancy, 7% (36/540) had incident preeclampsia and 42% (33/78) had recurrent preeclampsia. Compared with women without obesity, women with obesity had greater risk of incident preeclampsia (unadjusted risk ratio [RR], 2.2 [95% CI, 1.1–4.5]) and recurrent preeclampsia (unadjusted RR, 3.1 [95% CI, 1.5–6.7]). Preindex pregnancy chronic hypertension and diabetes mellitus were associated with incident, but not recurrent, preeclampsia (hypertension unadjusted RR, 7.9 [95% CI, 4.1–15.3]; diabetes mellitus unadjusted RR, 5.2 [95% CI, 2.5–11.1]. Women with new interpregnancy hypertension versus those without had a higher risk of incident and recurrent preeclampsia (incident preeclampsia unadjusted RR, 6.1 [95% CI, 2.9–13]); recurrent preeclampsia unadjusted RR, 2.4 [95% CI, 1.5–3.9]).

Conclusions
In this diverse sample of high‐risk US women, we identified modifiable and treatable risk factors, including obesity and hypertension for the prevention of preeclampsia.