bluuebunny/crossref_metadata_2025_split huggingface dataset:
Withaferin A – A natural multifaceted therapeutic compound
Authors: Vinod Sangeetha , Senthil Kalaiselvi 
Published: March 2021

COVID 19, which has lead to the death of millions of people, is still spreading worldwide. The development of any new drug after proper trial is much time consuming. This present global pandemic situation has lead the researchers around the world to run behind various existing antiviral and immunomodulatory natural compounds to overcome this contagious disease. Withania somnifera (ashwagandha) that is being used in Ayurvedic medicine for several ailments since several years is also said to pocess anti viral activity. Thus many of its metabolites are being studied individually for its efficacy against the dreadful disease. Withaferin A, a steroidal lactone from ashwagandha is one such prime metabolite which beyond acting as an antioxidant or antimicrobial agent, is also said to pocess anti-inflammatory to anti carcinogenic properties. Thus because of its wide spectrum of medicinal properties it has now become an attractive drug candidate for several preclinical studies. This increase in the demand for withaferin A has chanelled its way towards in vitro propagation of the plant Withania somnifera and trials on various strategies to increase the yield in terms of plant biomass as well as the withaferin content in the plants thus making it a better alternative to field grown plants. Thus this article reviews in depth on the important medicinal properties of withaferin A, its demand in Ayurveda industry and the in vitro strategies being carried out to overcome the demand.
IMPLEMENTASI TRAUMA HEALING DALAM PENANGANAN ANAK KORBAN TINDAK PIDANA KEKERASAN SEKSUAL
Authors: Yusuf Imam Maulana , Fatimah Siti , Noviawati Evi 
Published: March 2021

Mitra dalam kegiatan PKMS ini adalah PKK Desa Pajaten Kecamatan Sidamulih Kabupaten Pangandaran. Pemasalahan mitra adalah sebagai berikut: 1) Kader PKK Desa Pajaten Kecamatan Sidamulih Kabupaten Pangandaran belum memahami pengetahuan mengenai kekerasan seksual pada anak; 2) Belum optimalnya Keterlibatan Kader PKK Desa Pajaten Kecamatan Sidamulih Kabupaten Pangandaran dalam implementasi Trauma Healling dikarenakan sehingga tidak dapat membantu dalam penanganan terhadap anak korban kekerasan seksual; 3) Semakin banyaknya anak korban kekerasan seksual dalam kurun waktu 2017-2019 sehingga berpengaruh terhadap kekhawatiran lingkungan Desa Pajaten Kecamatan Sidamulih Kabupaten Pangandaran; 4) Kurangnya sikap aktif dan peduli terhadap sebuah kejadian yang tidak sesuai dengan aturan dan harus diselesaikan secara cepat dan tepat. Solusi yang ditawarkan untuk mengatasi permasalahan mitra yakni memberikan Pemahaman dan pelatihan penerapan metode Trauma Healing untuk anak korban tindak pidana kekerasaan seksual bagi Kader PKK Desa Pajaten Kecamatan Sidamulih Kabupaten Pangandaran. Penerapan metode Trauma Healing merupakan bentuk penanganan awal berupa bantuan psikologis bagi anak yang mengalami gejala Post Traumatic Stress Disorders (PTSD) akibat dari adanya tekanan atau goncangan mental yang disebabkan tindakan kekerasaan. Penerapan metode Trauma Healing yang praktis dapat dilakukan oleh keluarga, yaitu melalui terapi permainan (play therapy) dan motivasi diri (self motivation). Penggunaan metode Trauma Healing berupa terapi bermain (play therapy) lebih menekankan pada permainan yang syarat akan muatan edukasi dan dirancang agar dapat menuangkan simbolisasi tekanan atau kondisi traumatis bagi anak dan sekaligus sebagai adaftasi stres. Sedangkan metode motivasi diri (self motivation) yang bertujuan untuk meningkatkan motivasi diri bagi anak korban kekerasan seksual agar tidak mengalami ganguan hilang kepercayaan diri sehingga dapat bangkit dan semangat berkarya dalam rangka membangun masa depan yang lebih baik.
PENYULUHAN DALAM MEMINIMALISIR PEMBUANGAN SAMPAH UNTUK PENGEMBANGAN OBJEK WISATA DI PANTAI PANDAN CARITA KABUPATEN TAPANULI TENGAH
Authors: Wahyuni Esti , Aina Nur , Kristina Anjali , Poniman Poniman , Siregar Emma Suri Yanti , Rahimah Insaniah 
Published: March 2021

Sampah merupakan suatu bahan yang dibuang atau terbuang sebagai hasil dari aktifitas manusia maupun hasil aktifitas alam yang tidak atau belum memiliki nilai ekonomis. Persoalan sampah tidak henti hentinya untuk dibahas, karena berkaitan dengan pola hidup serta budaya masyarakat. Tapanuli Tengah adalah salah satu kabupaten yang memiliki potensi luar biasa dalam bidang wisata bahari, terutama pada pulau-pulau dan pantai yang indah. Hal ini menjadikan Kabupaten Tapanuli Tengah unggul dalam bidang wisata bahari. Akan tetapi, permasalahan utama mengenai sampah tetap menjadi sebuah permasalahan yang belum terselesaikan hingga saat ini. Kegiatan penyuluhan ini bertujuan untuk memberikan edukasi/kesadaran kepada masyarakat serta wisatawan Pantai Pandan Carita tentang: (1) Bahaya sampah (terutama plastik), (2) Cara menjaga kebersihan pantai (3) Cara pengelolaan sampah. Kegiatan ini dilakukan dengan metode ceramah, diskusi dan tanya jawab dengan menggunakan media flift chart. Hasil dari kegiatan ini adalah: (1) Media yang digunakan untuk kegiatan penyuluhan berupa flift chart tentang sampah dan efeknya terhadap kehidupan, (2) Hasil observasi, diskusi dan tanya jawab, menunjukkan bahwa melalui kegiatan penyuluhan ini pengetahuan masyarakat tentang bahaya sampah terhadap kehidupan, dan (3) Kesadaran masyarakat terhadap bahaya sampah terhadap kehidupan.
Explaining Variability in the Prevalence of Achilles Tendon Abnormalities: A Systematic Review With Meta-analysis of Imaging Studies in Asymptomatic Individuals
Authors: Docking Sean Iain , Hart Harvi F. , Rio Ebonie , Hannington Madeline Claire , Cook Jill L. , Culvenor Adam G. 
Published: March 2021

Objective To estimate the prevalence of, and factors associated with, Achilles tendon abnormalities observed on imaging in asymptomatic individuals. Design Systematic review with stratified meta-analysis and meta-regression. Literature Search Embase, Scopus, MEDLINE, CINAHL, SPORTDiscus, and Web of Science were searched from 1980 to August 2020. Study Selection Criteria We included studies that reported the prevalence of Achilles tendon abnormalities, observed with any imaging modality, in an asymptomatic population. We excluded studies if participant mean age was younger than 12 years or if participants had current/previous lower-limb tendon injuries/symptoms or other systemic conditions. Data Synthesis Random-effects proportion meta-analysis was used to estimate prevalence. We used meta-regression for continuous variables (mean age and body mass index [BMI], sample size, proportion of female participants) and stratified categorical variables (imaging modality and participation in physical activity) to explain between-study heterogeneity. Results We included 91 studies (10 156 limbs, 5841 participants). The prevalence of Achilles tendon abnormalities on imaging ranged from 0% to 80% per participant. Between-study heterogeneity was high (I2>90%, P<.001), precluding data pooling. Between-study heterogeneity was partly explained by participant mean BMI (slope, 2.8% per 1-unit increase in BMI; 95% confidence interval: 0.57%, 5.03%; P = .015) and participation in physical activity per limb, and mean age of 40 years old or older (P = .022) per participant. Conclusion There was substantial variability in the prevalence of Achilles tendon abnormalities on imaging in asymptomatic individuals. Higher prevalence of abnormalities was associated with older age (40 years old or older), higher BMI, and participation in physical activity. A large proportion of heterogeneity remains unaccounted for, likely due to variations in abnormality definitions and study design. J Orthop Sports Phys Ther 2021;51(5):232–252. Epub 28 Mar 2021. doi:10.2519/jospt.2021.9970
Role of Ayurveda Dincharya in Prevention of Infectious Diseases with special reference to Covid 19
Authors: Zoya Hasan Khan  , Trupti Thakre  , Sourabh G. Deshmukh  
Published: March 2021

Health means not only the freedom from disease but its ability to work with self-control and satisfaction. According to WHO health is to define as a state of complete physical, mental and social well being and not merely the absence of disease. Social and cultural pressures can only be endured by a healthy individual. Health is only the factor which helps to achieve Dharma (Attain Pious) Artha (Wealth) Kama (Desire) and Moksha (Salvation). As per Ayurveda, proper lifestyle or the person following Dinacharya, Ritucharya explained by acharya having disease-free life. The ideal lifestyle or routine or various duties from day to day in a day called daily regimen (Dinacharya). Recently Ayush Ministry has given some measures has to be taken in Dincharya. These measures include Dhumpana by dravyas having antiseptic and antimicrobial properties then, installing taila or ghrita in both the nostrils (Pratimarsha Nasya) at morning and evening helps to boost immunity. This practice acts as the first line of defense against the destabilizing influences of an external environment and will improve the condition of health. But most importantly, it will increase positivity in one, which is the prime requirement of the person dealing with COVID 19 patients. This should be the practical approach in the condition like atmosphere full of COVID 19 virus; One should always wear clean clothes and never share with others. Graha Dhuma is a unique technique mentioned in the texts for disinfecting the rooms. If all these daily regimens follow strictly, can help to prevent the spread of pandemic like covid-19.
Antimicrobial activity of plant based Essential Oils and Synergistic effect against selected Human Pathogenic Bacteria
Authors: Agneswari S  , Gopukumar S T  
Published: March 2021

The occurrence of multidrug resistant by pathogens is a universal issue for providing tolerable treatment for various infectious diseases. The predictable anti-microbial proxies are relatively active against plentiful strains, still need of more drugs against multidrug resistant pathogens. Herbal drugs have potential against antimicrobial activity from ancient days and their treatment of pathogenic diseases is increasing for developing plant based natural products. Essential oils have combat against antibiotic resistant bacteria. Thus our study was focused on plant based essential oil against human pathogenic bacteria. The necessary oil extracted from Curcuma longa and C. martini revealed protuberant anti-microbial accomplishments against B. subtilis, Escherichia coli, P. aeruginosa and S. aureus. Low concentration of C. longa oil at 10 µl inhibited the growth of all strains Bacillus subtilis followed by E. coli and S. aureus. Maximum bustle was noted in P. aerogenosa at 40 µl in both C. longa and C. martini oils. Human pathogenic strain treated with C. martini oil showed maximum inhibition in P. aerogenosa followed by B. subtilis, E. coli and S. aureus. Synergistic activity of oils against the strains showed maximum inhibition at 40 µl in P. aerogenosa.
PENGUKURAN EROSI PADA LAHAN RUMPUT KOLONJONO (Brachiaria mutica) DENGAN METODE PLOT KECIL DI HUTAN WANAGAMA I
Authors: Nugraha Irfansyah Diangga Yusuf , Kusumandari Ambar 
Published: March 2021

Hutan Wanagama I Gunungkidul memiliki topografi yang berbukit-bukit dan berlereng sehingga berpotensi tinggi menimbulkan erosi. Kombinasi tebal hujan yang relatif tinggi dan keadaan topografi dengan kemiringan curam berperan penting untuk menghasilkan aliran permukaan yang dapat menimbulkan erosi. Tujuan penelitian ini adalah untuk menganalisis hubungan antara tebal hujan terhadap aliran permukaan, aliran permukaan terhadap erosi, dan tebal hujan terhadap erosi dengan menggunakan analisis regresi linear sederhana. Di Hutan Wanagama I banyak terdapat lahan rumput Kolonjono (Brachiaria mutica) yang ditanam oleh masyarakat sekitar. Oleh karena itu, sangat mendesak untuk dilakukan penelitian erosi pada lahan rumput Kolonjono tersebut untuk menghindari terjadinya degradasi lahan. Penelitian ini dilakukan dengan menggunakan metode plot kecil untuk menganalisis tingkat erosi dan aliran permukaan. Pada penggunaan lahan rumput dibuat 3 plot kecil berukuran 22 m x 4 m, yang dipasang terpisah searah lereng, masing-masing mewakili bagian atas, tengah, dan bawah lereng. Hasil penelitian menunjukkan bahwa erosi selama penelitian tergolong sangat rendah, pada plot atas sebesar 52,52 kg/ha, pada plot tengah sebesar 48,44 kg/ha, dan pada plot bawah sebesar 57,90 kg/ha. Tebal hujan sangat memengaruhi aliran permukaan dan aliran permukaan sangat memengaruhi erosi. Hasil penelitian juga menunjukkan bahwa aliran permukaan selama penelitian pada plot atas sebesar 18,26 mm dengan koefisien aliran permukaan sebesar 0,0482, pada plot tengah sebesar 16,92 mm dengan koefisien aliran permukaan sebesar 0,0447, dan pada plot bawah sebesar 20,03 mm dengan koefisien aliran permukaan sebesar 0,0529 yang kesemuanya tergolong baik.
Personalities of the Hyperthymic Circle: Evolution of Conception Views and Patokinesis
Authors: Churkina A. M. , Subbotskaya N. V. 
Published: March 2021

The aim of review: to present the evolution of the concepts and pathokinesis of hyperthymia.Materials and methods: according to the keywords “personality of the hyperthymic circle”, “hyperthymia”, “bipolar affective disorder”, “chronic hypomania”, publications were searched in PubMed/MEDLINE, RSCI and other sources from the middle of the 19th century to the present.Conclusion: in science, historically, two intersecting psychopathological concepts of hyperthymia have developed, positioning it as a single continuum of bipolar disorder and affective temperament/personality disorder. In recent years, thanks to the success and introduction of biological psychiatry, studies have appeared that confirm the structural-dynamic and pathogenetic integrity of hyperthymia.
Neurobiology of Schizophrenia (to the Construction of Clinical and Biological Model)
Authors: Klyushnik T. P. , Smulevich A. B. , Zozulya S. A. , Voronova E. I. 
Published: March 2021

The objective: of the study was to present the main provisions of a new clinical and biological model of schizophrenia, which establishes links between disorders in the field of biological processes and the formation of positive and negative in the general psychopathological space of schizophrenia on the basis of the analysis of long-term results of clinical and biological research of the Mental Health Research Centre.Material and method: by keywords “schizophrenia”, “biological hypotheses of schizophrenia”, “neuroinflammation”, “neurodegeneration”; “positive disorders”, “negative disorders”, “neuroimmune relationships”, “catabolismof tryptophan”, “activation of microglia”, publications from PubMed/MEDLINE databases, RSCI and other sources were analyzedover the past 10 years in comparison with the results of clinical and biological studies of schizophrenia at the Mental Health Science Center.Results: comparison and analysis of current biological hypotheses of schizophrenia indicates that immunological studies are the most promising for solving the problem of establishing links between disorders of neurobiological processes and psychopathological specificities of schizophrenia. Within the framework of the new clinical and biological model, a key role is assigned to the process of neuroinflammation, which determines the pathogenesis of both negative and positive disorders by various, albeit interrelated, molecular mechanisms. One of these mechanisms, associated with the development of reversible positive symptom complexes, is based on an imbalance in the neurotransmitter systems, which is formed as a result of the effect of proinflammatory cytokines on tryptophan catabolism. Another mechanism that determines the development of negative symptom complexes is associated with the influence of cytotoxic metabolites on the processes of neurodegeneration. Conclusion: a new clinical and biological model of schizophrenia establishes a paradigm of the relationship between disorders in the sphere of biological processes determined by neuroinflammation/inflammation and the formation of the main procedural dimensions — positive and negative disorders in the general psychopathological space of schizophrenia. This model makes it possible to clarify some general provisions related to the pharmacotherapy of schizophrenia and the relief of negative disorders, and also serves as the basis for the development of new approaches to early diagnosis, clinical and social prognosis.
Peran Kader SPG (Stop Penyakit Gastritis) di Pondok Pesantren
Authors: Ghozali Ghozali , Sudirman Sudirman , Amalia Ayu Rizki , Setiawan Ferry 
Published: March 2021

Indonesia data penduduk yang menderita gastritis sekitar 40-50% diperkirakan adanya sebanyak 10 juta jiwa untuk itu penduduk yang berusia 40 tahun dari 6,5% jumlah populasi penduduk. Tahun 2016 di Kalimantan timur penyakit gastritis berada diurutan ke-4 penyakit terbanyak jumlah prevelensi sebanyak 8% dari jumlah penduduk. survey awal yang dilakukan di Pondok Pesantren Istiqomah pada enam bulan terakhir didapatkan data pravelensi sebanyak 32,3% mengalami maag, 12,6% mengalami diare, 3,1% mengalami scabies, dan Sebanyak 88% santri mengalami nyeri dan perih dibagian ulu hati. Tujuan terbentuknyaperan kader SPG (stop penyakit gastritis)untuk menjalankan kegiatan pendidikan kesehatan UKS di pondok pesantren dan untuk memonitoring para santri dengan media buku saku.Pengabdian Masyarakat ini menggunakan metode : (1) negosiasi (2) community empowerment (3) pembuatan buku saku “Stop Gastritis”. Dengan media penyampian berupa penayangan video, buku saku, poster yang telah diberikan santri dapat memahami dan meningkatkan pengetahuan mereka terhadap penyakit gastritis yang dimana penyakit gastritis merupakan penyakit yang banyak dikeluhkan oleh santri di pondok pesantren. Promosi kesehatan yang mendalam terkait dengan gastritis perlu di berikan kepada kader kesehatan pondok pesantren secara terus menerus.
Changes in Production Modes and Intellectual Relations in Managing the Behavior of Oil and Gas Labors in Muara Badak District
Authors: Priambodo Nalendro , Murlianti Sri , Nanang Martinus 
Published: March 2021

ABSTRACT:
This study aims to identify the pattern of changes in the mode of production of people who work as farmers and fishermen in Kutai Kartanegara Regency, especially Muara Badak District after the entry of the oil and gas industry in the region, and analyze how intellectual relations are in regulating the behavior of oil and gas workers along with the social, economic and political impacts. raised. This type of qualitative research uses the Grounded Theory approach. The results of this study indicate that changes in the way people produce from agriculture, plantations, and traditional fisheries in Muara Badak District have been accompanied by a mechanism for releasing social ties to land and sea through intermediary policies that are pro to the formation of industrial commodities for market interests and result in a decline in the domestic industry due to dependence. in the oil and gas industry. This dependence also gave birth to an intellectual layer and a working class that served the interests of the plantation, aquaculture and oil and gas-based industries. The process of its journey was accompanied by the emergence of various kinds of class conflicts, which gave rise to types of organic intellectuals who tried to fight back against the exploitation that occurred.
ABSTRAK:
Penelitian ini bertujuan untuk mengindentifikasikan pola perubahan mode produksi masyarakat yang berprofesi sebagai petani dan nelayan di Kabupaten Kutai Kartanegara, khususnya Kecamatan Muara Badak setelah masuknya industri migas di wilayah tersebut dan menganalisis bagaimana relasi intelektual dalam pengaturan prilaku buruh migas beserta dampak sosial, ekonomi dan politik yang ditimbulkan. Jenis penelitian kualitatif dengan menggunakan pendekatan Grounded Theory. Hasil penelitian ini menunjukan bahwa perubahan cara masyarakat berproduksi dari pertanian, perkebunan dan perikanan tradisional di Kecamatan Muara Badak ikut dibarengi dengan mekanisme pelepasan ikatan sosial dengan tanah dan laut melalui perantara kebijakan yang pro terhadap pembentukan komoditas industri untuk kepentingan pasar serta mengakibatkan kemunduran industri domestik akibat ketergantungan pada industri migas. Ketergantungan ini juga melahirkan lapisan intelektual dan kelas buruh yang mengabdi pada kepentingan industri berbasis perkebunan, pertambakan dan migas. Dalam proses perjalalanannya juga dibarengi dengan kemunculan berbagai macam konflik kelas sehingga memunculkan jenis intelektual organik yang berusaha melakukan perlawanan balik terhadap eksploitasi yang terjadi.
Reggae Music Community Practice in The City of Bontang (Descriptive Study of Bontang Reggae Community)
Authors: Syafa Muhammad Fachmi , Murlianti Sri 
Published: March 2021

ABSTRACT:
This study describes the practice of social life in the field of music in the city of Bontang, based on a sociological perspective using the generative formulation of the theory of Pierre Bourdieu (Habitus x Modal) + Ranah = Practice. This shows that the existence of the Bontang Reggae Community has produced several groups consisting of Reggae Grill, Slow Reggae, and Reggae Vibe groups as actors who practice in the realm of reggae music. This group was formed because of the different knowledge and understanding in the field of reggae music as a realm of space for social life, which then produced various habitus according to the realm of music in each group. Also, the existence of each group has been supported by the existence of a classification of capital which according to Bourdieu consists of four fundamental capitals including material capital, social capital, cultural capital, and symbolic capital. The three groups produce a practice resulting from dialectical relations through habitus-modal interactions in different and prominent domains of reggae music. The Reggae Grill group produces practices that come from symbolic capital, and circular habitus or the use of Cannabis, then the Slow Reggae group produces modern music practices that come from material capital and cultural capital, and the Reggae Vibe group produces solidarity practices that come from cultural capital and capital. symbolic, as well as group habitus.
ABSTRAK:
Penelitian ini menggambarkan praktik kehidupan sosial masyarakat pada bidang seni musik di kota Bontang, berdasarkan perspektif sosiologi dengan menggunakan rumusan generatif teori Pierre Bourdieu (Habitus x Modal) + Ranah = Praktik. Menunjukkan bahwa keberadaan Bontang Reggae Community telah melahirkan beberapa kelompok yang terdiri dari kelompok Reggae Grill, Slow Reggae, dan Reggae Vibe sebagai aktor yang melakukan praktik dalam ranah kehidupan seni musik reggae. Kelompok ini terbentuk karna adanya pengetahuan dan pemahaman yang berbeda-beda di bidang seni musik reggae sebagai ranah atau ruang kehidupan sosial, yang kemudian menghasilkan berbagai habitus sesuai dengan ranah musik pada masing-masing kelompok. Selain itu, keberadaan setiap kelompok telah didukung dengan adanya klasifikasi modal yang menurut Bourdieu terdiri dari keempat modal fundamental diantaranya adalah, modal material, modal sosial, modal kultural, dan modal simbolik. Ketiga kelompok tersebut menghasilkan sebuah praktik yang dihasilkan dari hubungan dialektis melalui interaksi habitus-modal dalam ranah musik reggae yang berbeda dan menonjol. Kelompok Reggae Grill menghasilkan praktik yang bersumber dari modal simbolik, dan habitus melingkar atau penggunaan Cannabis, kemudian kelompok Slow Reggae menghasilkan praktik musik modern yang bersumber dari modal material dan modal budaya, serta kelompok Reggae Vibe menghasilkan praktik solidaritas yang bersumber dari modal budaya, dan modal simbolik, serta habitus berkelompok.