bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case–control association study between polygenic risk score and COVID-19 severity in a Russian population using low-pass genome sequencing
Authors: Nostaeva Arina , Shimansky Valentin , Apalko Svetlana , Kuznetsov Ivan , Sushentseva Natalya , Popov Oleg , Asinovskaya Anna , Mosenko Sergei , Karssen Lennart , Sarana Andrey , Aulchenko Yurii , Shcherbak Sergey 
Published: December 2024

Abstract
The course of COVID-19 is highly variable, with genetics playing a significant role. Through large-scale genetic association studies, a link between single nucleotide polymorphisms and disease susceptibility and severity was established. However, individual single nucleotide polymorphisms identified thus far have shown modest effects, indicating a polygenic nature of this trait, and individually have limited predictive performance. To address this limitation, we investigated the performance of a polygenic risk score model in the context of COVID-19 severity in a Russian population. A genome-wide polygenic risk score model including information from over a million common single nucleotide polymorphisms was developed using summary statistics from the COVID-19 Host Genetics Initiative consortium. Low-coverage sequencing (5x) was performed for ~1000 participants, and polygenic risk score values were calculated for each individual. A multivariate logistic regression model was used to analyse the association between polygenic risk score and COVID-19 outcomes. We found that individuals in the top 10% of the polygenic risk score distribution had a markedly elevated risk of severe COVID-19, with adjusted odds ratio of 2.9 (95% confidence interval: 1.8–4.6, p-value = 4e-06), and more than four times higher risk of mortality from COVID-19 (adjusted odds ratio = 4.3, p-value = 2e-05). This study highlights the potential of polygenic risk score as a valuable tool for identifying individuals at increased risk of severe COVID-19 based on their genetic profile.
‘The pieces that are in the hands of everyone belong to the public’: Philippe-Emmanuel de Coulanges, Song Games and Operatic Artefacts in Seventeenth-Century Paris
Authors: Romey John 
Published: December 2024

Abstract
In seventeenth-century Paris, the performance of an opera or other staged spectacle was an interactive event that engendered countless subsequent performative acts. An operatic premiere infused the Parisian songscape with new musical material that reverberated in various social spheres, from the galant airs performed by mondains at gatherings of literary elites to the ribald songs performed by street singers. The chansons of Philippe-Emmanuel de Coulanges provide a window into the musical games that unfolded across fashionable Paris. These traces of ephemeral song networks illuminate how spectacles had a ripple effect throughout Paris and beyond when individuals performed, manipulated, quoted and parodied operatic artefacts in various social contexts and spaces. The study of the ways in which audiences interacted with operatic music in turn reveals how contemporary spectators understood, listened to and valued a work and its components, as they dissected and reused elements in their quotidian social experiences.
Orchid embryo-to-seed (E:S) ratio as an indicator of germination behaviour and its ecological implications
Authors: Oikonomidis Spyridon , Thanos Costas A. 
Published: December 2024

Abstract
Although the seeds of various Orchidaceae members can be readily germinated on sterile nutrient media, numerous species exhibit complete asymbiotic germination failure. Also, while seed morphology in orchids has been previously linked to dispersal, associations with germinability have not been widely explored. We compiled seed morphometric and germination data for 203 orchid species globally, drawing from international literature and our lab's unpublished findings. Based on (a) final germination percentage and (b) pre-treatment duration, two distinct groups of asymbiotic germination behaviour emerged – termed compliant and defiant, respectively. Additionally, a statistically significant relationship between germinability and the embryo-to-seed (E:S) length ratio was observed. E:S values tended to be lower in species with defiant germination and higher in those with compliant germination. We further correlated seed morphometric and germination data with phylogenetically and ecologically significant parameters (subfamily, growth form, mycoheterotrophy level, climatic zone and habitat shadiness). Notably, lower E:S values and defiant germination predominate in orchids of shaded habitats, while compliant germination is more prevalent in open habitats. Lastly, considering the mycoheterotrophy continuum, we propose that the reduction in the E:S ratio is linked to the adaptation of various orchid lineages to shaded habitats through both an increased dispersal ability and their greater reliance on fungal symbiosis.
Different bilingual experiences predict different executive functions: Evidence from mouse-tracking
Authors: Yurtsever Aslı , Sotebeer Kaiah N. , Grundy John G. 
Published: December 2024

Abstract
There is evidence to suggest that the effects of bilingualism on executive functions (EFs) need to be examined along a continuum rather than a dichotomy. The present study addressed this need by examining the influence of different bilingual experiences on executive functioning using a Flanker and Stroop mouse-tracking task that taps into more dynamic cognitive processes than typical behavioral paradigms. We sampled 98 bilingual young adults and investigated conflict and sequential congruency effects (SCEs). We found that mouse-tracking metrics captured links that were not identified with overall reaction times. SCEs were more sensitive to detecting relations between L2 experiences and EF than simple conflict effects. Second-language age of acquisition and L1/L2 switching frequency consistently predicted EF outcomes. This association was moderated by the attentional demands of the task. These findings highlight the complexity of the effects of bilingualism on cognition, and the use of more sensitive measures to capture these effects.
Exploring the perceptions of people diagnosed with schizophrenia and their family members to inform the cultural adaptation of cognitive behavioural therapy for psychosis in Saudi Arabia: a qualitative study
Authors: Aljuhani Muteb , Lovell Karina , Price Owen , Almutairi Asrar 
Published: December 2024

Abstract
Cognitive behavioural therapy (CBT) is one of the best-evidenced psychosocial interventions for psychosis and is recommended by the National Institute for Health and Care Excellence and the American Psychiatric Association. CBT was developed and derived from Western cultural values, which may not be appropriate for non-Western cultures. Trials of CBT in Western countries have indicated that participants from ethnic minority groups demonstrate low rates of engagement, retention, and recruitment. This indicates that the principles underlying CBT may conflict with individual beliefs and cultural values in non-Western countries. Therefore, we interviewed 15 people diagnosed with schizophrenia and 15 with their family members to explore the beliefs and attitudes of people diagnosed with schizophrenia and their family members concerning the proposed CBT intervention for psychosis in the Saudi context. The findings revealed that most participants accepted the proposed intervention. Important factors that influenced participants’ engagement and motivation in the CBT intervention were related to the therapist’s qualities (sex, empathy, and competence), family involvement, religion, and the number and format of CBT sessions for psychosis.

Key learning aims

(1)
To explore the beliefs and attitudes of people diagnosed with schizophrenia concerning the proposed CBT intervention for psychosis and how to improve it to make it more appropriate for their needs and cultures.

(2)
To explore the beliefs and attitudes of family members of people diagnosed with schizophrenia concerning the proposed CBT intervention for psychosis and how to improve it to make it more appropriate to their needs and culture.
Satellite Observations Reveal Widespread Color Variations in Global Lakes Since the 1980s
Authors: Shen Xiaoyi , Ke Chang‐Qing , Duan Zheng , Cai Yu , Li Haili , Xiao Yao 
Published: December 2024

AbstractThe color of lakes is an essential indicator of the local ecological state, and the corresponding changes can reflect the physical and biochemical processes of lakes. However, worldwide changes in lake color and their drivers remain largely unknown. Here, we analyze the long‐term color distributions and changes of 67,579 lakes worldwide from 1984 to 2021 by utilizing 32 million consistent satellite observations. Blue lakes (<495 nm) were primarily located in high‐latitude and high‐elevation areas. Green lakes (495–560 nm) were more prevalent in densely populated middle‐latitude regions, while most red and yellow colors (≥560 nm) were located in the Southern Hemisphere. Our findings reveal distinct temporal patterns of lake color changes, with the majority of global lakes shifted toward shorter wavelengths. This phenomenon is more common in Warm Temperate and Boreal zones. Lake color changes are closely linked to basin vegetation conditions, population, water volume change, and lake area. Our study provides essential references for monitoring the ecological status of global lakes, further supporting the sustainable development of water resources in the future.
Characteristics of “Zebra Stripes” of Relativistic Electrons Unveiled by CIRBE/REPTile‐2 Measurements and Test Particle Simulations
Authors: Mei Yang , Li Xinlin , O’Brien Declan , Xiang Zheng , Zhao Hong , Sarris Theodore , Hogan Benjamin , Brennan David , Temerin Michael 
Published: December 2024

AbstractDrift periodic echoes of electrons in the inner belt appear as structured bands in energy spectrograms, also known as “zebra stripes”. Such phenomenon is normally observed at energies from 10s of keV to ∼250 keV. We report multiple series of zebra stripes of relativistic electrons observed by the recent Colorado Inner Radiation Belt Experiment (CIRBE) CubeSat. The high energy resolution measurements taken by the REPTile‐2 (Relativistic Electron and Proton Telescope integrated little experiment‐2) instrument onboard CIRBE show that zebra stripes of radiation belt electrons can be observed from 300 keV to >1 MeV, crossing the L range from 1.18 to >3, from quiet times to storm times. Through test particle simulations, we show that a prompt electric field with a peak amplitude ∼5 mV/m in near‐Earth space can trigger zebra stripes of relativistic electrons. Azimuthal inhomogeneity of electron distribution caused by the prompt electric field modulates the electron energy spectrum by energy‐dependent drift phases to form zebra stripes. Though zebra stripes are observed in both belts, they tend to last longer and appear more frequently in the inner belt. Zebra stripes in the outer belt will have a shorter lifetime due to more perturbations there, including energy and pitch‐angle diffusion, which diminish the structure. This study demonstrates the important role of electric fields in the dynamics of relativistic electrons and contributes to the understanding of the mechanisms creating and diminishing zebra stripes.
Fast detection of protein kinase B in chrysin treated colorectal cancer cells using a novel multicore microfiber biosensor
Authors: Tian Zhen , Xuan Hongzhuan , Yao Yicun , Hao Shengyu , Zhang Zhichao , Zhang Bingyuan , Zhang Jingao , Zhang Liqiang , Sang Xinzhu , Yuan Jinhui , Farrell Gerald , Wu Qiang 
Published: December 2024

AbstractRapid and accurate determination of target proteins in cells provide essential diagnostic information for early detection of diseases, evaluation of drug responses, and the study of pathophysiological mechanisms. Traditional Western blotting method has been used for the determination, but it is complex, time-consuming, and semi-quantitative. Here, a tapered seven-core fiber (TSCF) biosensor was designed and fabricated. By immobilizing protein kinase B (PKB), also known as AKT, antibody onto TSCF surface, the microfiber biosensor can be used for quantitatively detecting the AKT level in solution concentrations as low as 0.26 ng/mL. To test the reliability of the TSCF sensing method in a medical application, the TSCF biosensor was used to study the relationship between chrysin’s anticancer effect and the concentration of AKT in a human colorectal cancer cell line (LoVo cells). The results reveal that the inhibitory effect of chrysin on LoVo cells is positively correlated with the dose, agreeing well with the equivalent results using the traditional Western blotting method.
Unlocking the power of multi‐modal fusion in 3D object tracking
Authors: Hu Yue 
Published: December 2024

Abstract3D Single Object Tracking plays a vital role in autonomous driving and robotics, yet traditional approaches have predominantly focused on using pure LiDAR‐based point cloud data, often neglecting the benefits of integrating image modalities. To address this gap, we propose a novel Multi‐modal Image‐LiDAR Tracker (MILT) designed to overcome the limitations of single‐modality methods by effectively combining RGB and point cloud data. Our key contribution is a dual‐branch architecture that separately extracts geometric features from LiDAR and texture features from images. These features are then fused in a BEV perspective to achieve a comprehensive representation of the tracked object. A significant innovation in our approach is the Image‐to‐LiDAR Adapter module, which transfers the rich feature representation capabilities of the image modality to the 3D tracking task, and the BEV‐Fusion module, which facilitates the interactive fusion of geometry and texture features. By validating MILT on public datasets, we demonstrate substantial performance improvements over traditional methods, effectively showcasing the advantages of our multi‐modal fusion strategy. This work advances the state‐of‐the‐art in SOT by integrating complementary information from RGB and LiDAR modalities, resulting in enhanced tracking accuracy and robustness.
Reduced component cascaded switched capacitor multilevel inverter for renewable energy applications
Authors: Seifi Ali , Hosseini Seyed Hossein , Hagh Mehrdad Tarafdar , Hosseinpour Majid 
Published: December 2024

AbstractMulti‐level inverters (MLIs) have a wide range of applications that try to minimize power electronics such as switches, diodes, and DC sources. Switched‐capacitor inverters are offered with reduced sources that reduce the number of sources and switches. This paper presents a switched capacitor‐based MLI with fewer components for grid‐connected applications. The basic topology can inherently charge and stabilize the capacitor voltage without additional circuits, sensors, or initial charges. This topology is generalized as a cascaded structure and produces higher voltage levels. The proposed cascaded topology is improved regarding the number of switches and components and the voltage stress on switches. This topology is compared with several similar topologies to evaluate the advantage of the proposed topology. For this purpose, a comprehensive comparison is performed by defining the cost function. The proposed topology under dynamic operating conditions is examined and validated. The phase‐shifted pulse width modulation is used to perform the switching of the proposed topology. Grid‐connected results for the proposed basic topology are also presented. The simulation results in MATLAB software and the laboratory results from a prototype made in the laboratory demonstrate the correctness and capability of the proposed converter.
Experimental verification of coverage control of multi‐agent systems with obstacle avoidance
Authors: Siri Fidelia Chaitra , Song Jie , Svinin Mikhail 
Published: December 2024

AbstractMulti‐agent systems are a significant and popular area of study in robotics, focusing on efficient and safe coordination among multiple agents. This paper presents algorithms for safe coverage control in multi‐agent systems, addressing key challenges such as coverage control and obstacle avoidance. The coverage control problem is tackled using centroidal Voronoi tessellation with a time‐varying density function, which optimally distributes agents based on the spatial density of the area of interest. To ensure collision‐free manoeuvres, a control barrier function based controller is developed for obstacle avoidance. The proposed controller's effectiveness is validated through a custom Python simulator and experimental tests conducted in the robot operating system–Gazebo environment. The results demonstrate the efficacy of the centroidal Voronoi tessellation and control barrier function approaches in achieving both optimal agent distribution and robust obstacle avoidance.
Venous Sinus Stenting for Cerebrospinal Fluid Leaks in Setting of Idiopathic Intracranial Hypertension—An Institutional Series and Systematic Review of Literature
Authors: Lim Jaims , Jaikumar Vinay , Okai Bernard K. , Malueg Megan D. , Khan Hamid Sharif , Liu Collin , Fritz Alexander , Ghannam Moleca , Levy Elad I. , Siddiqui Adnan H. , Vakharia Kunal 
Published: December 2024

Abstract
Introduction Chronic cerebrospinal fluid (CSF) pressure in idiopathic intracranial hypertension (IIH) can erode the skull base and cause CSF leaks, necessitating surgical repair or other interventions. Venous sinus stenting (VSS) may restore normal CSF reabsorption and flow, reducing elevated pressures and warranting further investigation as a treatment for IIH-related CSF leaks.
Methods We retrospectively reviewed charts of IIH patients who underwent VSS for CSF leak repair, analyzing clinical presentation, imaging, treatment, and follow-up. A systematic review of PubMed and Embase was conducted, with continuous variables reported as medians and interquartile ranges (IQRs).
Results We included two institutional cases and seven cases from the systematic review. Median age was 51 years (35–53), with eight female and six obese patients. Among six patients with prior confirmed IIH, four of five treated with acetazolamide were refractory. All presented with CSF rhinorrhea, six had a history of leaks, and four were recurrences. Seven had bony dehiscence. All had bilateral venous stenosis with a pressure gradient of 6 mmHg (3–8.25) and underwent unilateral VSS, with one patient also undergoing angioplasty. Over a 12-month follow-up (11–27), leaks resolved in all patients but one within 3 months (0.875–3). Four had recurrences by 7.15 months (4.8–9); one resolved spontaneously, another after angioplasty, and two required ventriculoperitoneal shunting. One patient underwent additional dural grafting for new sphenoid dehiscence, achieving resolution.
Conclusion VSS can be an effective initial treatment for IIH-related CSF leaks; but if VSS does not adequately address underlying intracranial pressures, additional medical and surgical interventions are warranted to prevent recurrent leaks.
Synthesis and characterization of alkali metal salts bearing a phenalenyl-based tridentate ligand
Authors: Kodama Takuya , Noguchi Hikaru , Tsurugi Hayato , Tobisu Mamoru 
Published: December 2024

Abstract
A series of alkali metal salts bearing a phenalenyl-based N,N,N-tridentate ligand was systematically characterized by spectroscopic and computational methods. The electronic absorption spectra of alkali metal salts exhibited bathochromic shift compared to that of the corresponding free ligand. TD-DFT calculations suggest that alkali metal salts possess narrower HOMO-LUMO gaps than the free ligand. In addition, the natural charges for the alkaline metal cations are increased from lithium to heavier alkali metals, resulting in an increase in the negative charge within the phenalenyl ligand, leading to a destabilizing of the energies of occupied molecular orbitals involved in the bathochromic shift.
Chest pain after elective percutaneous coronary intervention as trigger of takotsubo syndrome—a case report
Authors: Castiglione Vincenzo , Arzilli Chiara , Ciardetti Marco , Emdin Michele , Coceani Michele 
Published: December 2024

Abstract

Background
Takotsubo syndrome (TTS) is characterized by transient left ventricular dysfunction, often triggered by emotional or physical stress. It usually presents with clinical features similar to acute coronary syndrome, making its occurrence following elective percutaneous coronary intervention (PCI) challenging to diagnose and treat.

Case summary
A 67-year-old man with ischaemic heart disease and recurrent angina underwent elective PCI of the right coronary artery. The procedure, although technically challenging, was completed without immediate complications. However, shortly after the intervention, the patient experienced acute chest pain, initially thought to be due to subocclusion of a postero-lateral branch, which was treated with balloon angioplasty. Despite this intervention, the patient developed severe ventricular arrhythmias and exhibited dynamic electrocardiographic changes and echocardiographic features consistent with TTS. Cardiac magnetic resonance (CMR) imaging confirmed the diagnosis, revealing classic apical ballooning and left ventricular dysfunction. With comprehensive medical management and haemodynamic support, the patient gradually recovered. He was discharged after stabilization, with follow-up showing complete resolution of the left ventricular dysfunction.

Discussion
This case highlights the importance of recognizing TTS as a potential complication following PCI, particularly in patients with a heightened stress response. It emphasizes the need for increased awareness and the use of advanced diagnostic tools, such as CMR imaging, to accurately identify TTS. Early diagnosis and appropriate management are crucial for improving outcomes, especially in complex PCI cases where TTS can mimic more common coronary complications.
Wait and trust: conservative management of bradyarrhythmias due to dengue infection: a case report
Authors: Cortez Maicol , López Bryam , Angulo Bryan , Palomino Milagros , Mancha Carlos 
Published: December 2024

Abstract

Background
This case report highlights the conduction disorder anomalies associated with dengue infection, particularly bradyarrhythmias due to dysfunction of the sinus node and atrioventricular node, which may require cardiac stimulation such as pacemaker implantation. This case emphasizes the importance of continuous monitoring and the use of additional diagnostic techniques to detect complications in a timely manner.

Case summary
A 31-year-old male patient was admitted to our institution with symptoms of dyspnoea, orthopnoea, and severe bradycardia. During hospital admission, atrial fibrillation with a low ventricular response was evident. A 24-h Holter examination revealed additional electrical conduction abnormalities, including first-, second-, and third-degree atrioventricular block, 3.8 s pauses, and migrating atrial rhythm. Since the patient remained asymptomatic and did not present circulatory compromise, conservative management was chosen, with gradual recovery observed during the 30-day follow-up.

Discussion
Dengue can significantly affect the cardiovascular system, presenting a variety of abnormalities in cardiac conduction. This case highlights electrical abnormalities and the importance of proper evaluation and management. It was decided to avoid temporary or permanent pacemaker implantation. This case underscores the need for continuous monitoring and the use of alternative diagnostic tools demonstrating that arrhythmias in this context can be successfully managed conservatively.