bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adolescent intergroup connections and their developmental benefits: Exploring contributions from social network analysis
Authors: Kornienko Olga , Rivas‐Drake Deborah 
Published: November 2021

AbstractBecause diverse school settings provide students with opportunities to form same‐ and cross‐group relationships with youth of various ethnicities and races, an important question arises: How are these opportunities taken up, and what are the developmental implications of doing so? Accumulating evidence suggests that these connections are beneficial to youth. Yet, we currently have a limited understanding of the specific peer mechanisms that produce these benefits. Addressing this gap requires adopting a relational perspective and using social network analysis (SNA) tools to characterize the theorized developmental mechanisms through which intergroup connections promote adolescent psychological and academic adjustment. To do so, we present an integrative account in which intergroup connections are viewed as developing and influencing adolescent outcomes in the context of broader peer networks. We then discuss the need to disentangle peer network selection from peer influence dynamics to provide an accurate account of multiple processes through which intergroup connections shape development and briefly explore how these goals are achieved by using statistical approaches to modeling of social networks. This review seeks to guide the next generation of research to more thoroughly test and refine the developmental theory and advance knowledge that will inform interventions to promote intergroup connections and their academic and socio‐emotional benefits.
Base cation‐enhancing role of corn straw biochar in an acidic soil
Authors: Yuan Jinhua , E Shengzhe , Che Zongxian 
Published: November 2021

AbstractBiochar affects base cation retention and leaching when it is used to enhance the base cation status of acidic soil. However, the details of its contribution are not yet clear. In this study, six loadings of corn straw biochar (0%, 2%, 4%, 6%, 8% and 10%, w/w) were applied to an acidic Ferralsol and incubated for 1 year. The results showed that the content of water‐soluble and exchangeable base cations of K, Na, Ca and Mg increased with increasing levels of biochar in amended soil. The percentage of water‐soluble Na, Ca and Mg of amended soil significantly decreased, while the percentage of exchangeable K, Ca and Mg increased significantly after the addition of biochar. For K and Na, biochar affected their leaching concentrations both as a source and by increasing the pH. For Ca, biochar reduced Ca leaching when the biochar loading was ≥4%, and the contribution increased from 30.8% to 100% at 4%–10% loading. For Mg, biochar reduced Mg leaching at biochar loadings 2%–10%, the reduction increasing from 22.0% to 70.5%. The results show that corn straw biochar can increase the content of the soil nutrient base cations K, Ca and Mg by increasing their exchangeable forms and enhance soil retention by decreasing their leaching. Thus, corn straw biochar can be used to effectively improve acidic soil base cation fertility.
5S‐IGS rDNA in wind‐pollinated trees (Fagus L.) encapsulates 55 million years of reticulate evolution and hybrid origins of modern species
Authors: Cardoni Simone , Piredda Roberta , Denk Thomas , Grimm Guido W. , Papageorgiou Aristotelis C. , Schulze Ernst‐Detlef , Scoppola Anna , Salehi Shanjani Parvin , Suyama Yoshihisa , Tomaru Nobuhiro , Worth James R. P. , Cosimo Simeone Marco 
Published: November 2021

SUMMARYStandard models of plant speciation assume strictly dichotomous genealogies in which a species, the ancestor, is replaced by two offspring species. The reality in wind‐pollinated trees with long evolutionary histories is more complex: species evolve from other species through isolation when genetic drift exceeds gene flow; lineage mixing can give rise to new species (hybrid taxa such as nothospecies and allopolyploids). The multi‐copy, potentially multi‐locus 5S rDNA is one of few gene regions conserving signal from dichotomous and reticulate evolutionary processes down to the level of intra‐genomic recombination. Therefore, it can provide unique insights into the dynamic speciation processes of lineages that diversified tens of millions of years ago. Here, we provide the first high‐throughput sequencing (HTS) of the 5S intergenic spacers (5S‐IGS) for a lineage of wind‐pollinated subtropical to temperate trees, the Fagus crenata – F. sylvatica s.l. lineage, and its distant relative F. japonica. The observed 4963 unique 5S‐IGS variants reflect a complex history of hybrid origins, lineage sorting, mixing via secondary gene flow, and intra‐genomic competition between two or more paralogous‐homoeologous 5S rDNA lineages. We show that modern species are genetic mosaics and represent a striking case of ongoing reticulate evolution during the past 55 million years.
Effects of 0.0015% preservative‐free tafluprost on the equine eye
Authors: Azimpour Saeed , Emami alagha Hannah , Faghihi Houman , Rajaei Seyed Mehdi , Shokoohimand Armin 
Published: November 2021

AbstractObjectiveThe purpose of this study was to determine the effects and potential side effects of topical preservative‐free (PF) tafluprost 0.0015% in ophthalmologically normal horses.AnimalsFive adult grade horses.ProceduresOne of the eyes of each horse was randomly chosen as the “treatment” eye, and consequently, the contralateral eye served as the “control.” A single dose of PF tafluprost 0.0015% (0.2 mL) was instilled in the treated eye of each horse. Intraocular pressure (IOP), Schirmer's tear test (STT) levels of each eye, and an ophthalmic examination were performed at T0 (baseline), T30, T120, T24 h, and T48 h.ResultsThe mean IOP values of the treated eyes at baseline (T0), T30, T120, T24 h, and T48 h were 25.4 ± 4.8 mmHg, 21.2 ± 1.92 mmHg, 15.20 ± 2.48 mmHg, 18.40 ± 1.51 mmHg, and 24.60 ± 1.94 mmHg, respectively. Significant differences were observed between the mean baseline IOP level and the T120 and T24 h time points (p = .001 and p = .009). The mean STT levels at each time point showed insignificant fluctuations during the study (p = .140). Adverse effects such as chemosis and episcleral injection were observed 30 min after the instillation of tafluprost 0.0015% (T30). Blepharospasm and conjunctival hyperemia were observed 120 min (T120) after the administration of the medication.Conclusion and clinical relevanceTafluprost 0.0015% showed potential in reducing IOP, but due to its local side effects, it is not a good candidate for management of glaucoma in horses. Tafluprost did not notably affect STT.
In Vitro
Susceptibility of Gram-Negative Pathogens to Cefiderocol in Five Consecutive Annual Multinational SIDERO-WT Surveillance Studies, 2014 to 2019
Authors: Karlowsky James A. , Hackel Meredith A. , Takemura Miki , Yamano Yoshinori , Echols Roger , Sahm Daniel F. 
Published: November 2021

We report
in vitro
susceptibility data from five consecutive annual SIDERO-WT surveillance studies (2014 to 2019) for cefiderocol and comparators tested against Gram-negative clinical isolates from North America and Europe. CLSI broth microdilution was used to determine MICs for
Enterobacterales
(
n
= 31,896),
Pseudomonas aeruginosa
(
n
= 7,700),
Acinetobacter baumannii
complex (
n
= 5,225),
Stenotrophomonas maltophilia
(
n
= 2,030), and
Burkholderia cepacia
complex (
n
= 425).
Slow slip in subduction zones: Reconciling deformation fabrics with instrumental observations and laboratory results
Authors: Oncken O. , Angiboust S. , Dresen G. 
Published: November 2021

AbstractCataclasites are a characteristic rock type found in drill cores from active faults as well as in exposed fossil subduction faults. Here, cataclasites are commonly associated with evidence for pervasive pressure solution and abundant hydrofracturing. They host the principal slip of regular earthquakes and the family of so-called slow earthquakes (episodic slip and tremor, low to very low frequency earthquakes, etc.). Slip velocities associated with the formation of the different types of cataclasites and conditions controlling slip are poorly constrained both from direct observations in nature as well as from experimental research. In this study, we explore exposed sections of subduction faults and their dominant microstructures. We use recently proposed constitutive laws to estimate deformation rates, and we compare predicted rates with instrumental observations from subduction zones. By identifying the maximum strain rates using fault scaling relations to constrain the fault core thickness, we find that the instrumental shear strain rates identified for the family of “slow earthquakes” features range from 10−3s−1 to 10−5s−1. These values agree with estimated rates for stress corrosion creep or brittle creep possibly controlling cataclastic deformation rates near the failure threshold. Typically, pore-fluid pressures are suggested to be high in subduction zones triggering brittle deformation and fault slip. However, seismic slip events causing local dilatancy may reduce fluid pressures promoting pressure-solution creep (yielding rates of &lt;10−8 to 10−12s−1) during the interseismic period in agreement with dominant fabrics in plate interface zones. Our observations suggest that cataclasis is controlled by stress corrosion creep and driven by fluid pressure fluctuations at near-lithostatic effective pressure and shear stresses close to failure. We posit that cataclastic flow is the dominant physical mechanism governing transient creep episodes such as slow slip events (SSEs), accelerating preparatory slip before seismic events, and early afterslip in the seismogenic zone.
The rise and demise of deep accretionary wedges: A long-term field and numerical modeling perspective
Authors: Angiboust Samuel , Menant Armel , Gerya Taras , Oncken Onno 
Published: November 2021

AbstractSeveral decades of field, geophysical, analogue, and numerical modeling investigations have enabled documentation of the wide range of tectonic transport processes in accretionary wedges, which constitute some of the most dynamic plate boundary environments on Earth. Active convergent margins can exhibit basal accretion (via underplating) leading to the formation of variably thick duplex structures or tectonic erosion, the latter known to lead to the consumption of the previously accreted material and eventually the forearc continental crust. We herein review natural examples of actively underplating systems (with a focus on circum-Pacific settings) as well as field examples highlighting internal wedge dynamics recorded by fossil accretionary systems. Duplex formation in deep paleo–accretionary systems is known to leave in the rock record (1) diagnostic macro- and microscopic deformation patterns as well as (2) large-scale geochronological characteristics such as the downstepping of deformation and metamorphic ages. Zircon detrital ages have also proved to be a powerful approach to deciphering tectonic transport in ancient active margins. Yet, fundamental questions remain in order to understand the interplay of forces at the origin of mass transfer and crustal recycling in deep accretionary systems. We address these questions by presenting a suite of two-dimensional thermo-mechanical experiments that enable unravelling the mass-flow pathways and the long-term distribution of stresses along and above the subduction interface as well as investigating the importance of parameters such as fluids and slab roughness. These results suggest the dynamical instability of fluid-bearing accretionary systems causes either an episodic or a periodic character of subduction erosion and accretion processes as well as their topographic expression. The instability can be partly deciphered through metamorphic and strain records, thus explaining the relative scarcity of paleo–accretionary systems worldwide despite the tremendous amounts of material buried by the subduction process over time scales of tens or hundreds of millions of years. We finally stress that the understanding of the physical processes at the origin of underplating processes as well as the forearc topographic response paves the way for refining our vision of long-term plate-interface coupling as well as the rheological behavior of the seismogenic zone in active subduction settings.
A Retrospective Analysis of COVID-19-infected Patients with Acute Hepatitis who Develop Acute Liver Failure in a Safety Net Hospital
Authors: Pellegrini Jr. James Robert , Sabbula Bhanu , Russe-Russe Jose R , Munshi Rezwan F , Meshoyrer Daniel , Sajid Nourma , Gutierrez Alex , Munnangi Swapna , Szydziak Elisa , Akella Jagadish 
Published: November 2021

ObjectiveIn early 2019, a new coronavirus called SARS-CoV-2 emerged and changed the course of civilization. Our study aims to analyze the association between acute liver failure (ALF) and mortality in patients infected with COVID-19. A retrospective analysis of 864 COVID-19-infected patients admitted to Nassau University Medical Center in New York was performed.DesignALF is identified by acute liver injury (elevations in liver enzymes), hepatic encephalopathy and an international normalised ratio greater than or equal to 1.5. These parameters were analysed via daily blood work and clinical assessment. Multivariate logistic regression model predicting mortality and controlling for confounders such as age, coronary artery disease, intubation, hypertension, diabetes mellitus and acute kidney injury were used to determine the association of ALF with mortality.ResultsA total of 624 patients, out of the initial 864, met the inclusion criteria—having acute hepatitis and COVID-19 infection. Of those 624, 43 (6.9%) patients developed ALF during the course of their hospitalisation and their mortality rate was 74.4%. The majority of patients with ALF were male (60.6%). The logistic model predicting death and controlling for confounders shows COVID-19 patients with ALF had a nearly four-fold higher odds of death in comparison to those without ALF (p=0.0063).ConclusionsFindings from this study suggest that there is a significant association between mortality and the presence of ALF in patients infected with COVID-19. Further investigation into patients with COVID-19 and ALF can lead to enhanced treatment regimens and risk stratification tools, which can ultimately improve mortality rates during these arduous times.
Emilia-Romagna Regional Blood System accreditation as an example of improvement through application of specific requirements: a retrospective analysis
Authors: Cortellazzi Pilade , Carini Davide , Bolzoni Luana , Cattadori Evelina , Randi Vanda 
Published: November 2021

BackgroundInstitutional accreditation in Italy represents the license given by a region to a public or private facility to provide services in the name and on behalf of the National Health Service. This study aims to evaluate the improvement of the Emilia-Romagna Regional Blood System and to highlight its unresolved issues, analysing non-conformities observed during accreditation and maintenance inspections between 2013 and 2018.MethodsAll the Emilia-Romagna Regional Blood facilities were invited to participate in this study voluntarily and anonymously. Participants had to access a web application that we developed specifically. For each of the three inspections evaluated in this study, they had to enter data about the state of their organisation branches and non-conformities observed by regional inspectors. All data entered were finally exported from the web application database and analysed with spreadsheets. Statistical analysis was performed using Wilcoxon signed-rank test with continuity correction.Results17 structures took part in the study, with a total of 174 organisation branches. The number of branches changed over the years because of new openings and closures due to reorganisations or non-conformities that were too difficult to correct. Inspectors observed 2381 non-conformities (291 structural, 611 technological and 1479 organisational). As a result of accreditation inspections and consequent improvement actions, non-conformities were reduced by 88%. The most frequent non-conformities concerned the management software and the transportation of blood and blood components.ConclusionAn improvement in the Emilia-Romagna Regional Blood System over time is evident: institutional accreditation certainly pushed it to change and overcome its problems to comply with specific requirements. The remaining non-conformities after the three inspections were mostly organisational and management software was the most critical issue. Despite these non-conformities, all currently active structures are accredited and guarantee high standards of quality and safety of products and services.
PAX-D: study protocol for a randomised placebo-controlled trial evaluating the efficacy and mechanism of pramipexole as add-on treatment for people with treatment resistant depression
Authors: Au-Yeung Sheena Kristine , Griffiths James , Roberts Sophie , Edwards Chloe , Yu Ly-Mee , Bogacz Rafal , Rendell Jennifer , Attenburrow Mary-Jane , Watson Stuart , Chan Fiona , Cipriani Andrea , Cleare Anthony , Harmer Catherine J , Kessler David , Evans Jonathan , Lewis Glyn , Singh Ilina , Simon Judit , Harrison Paul J , Cowen Phil , Shanyinde Milensu , Geddes John , Browning Michael 
Published: November 2021

IntroductionClinical depression is usually treated in primary care with psychological therapies and antidepressant medication. However, when patients do not respond to at least two or more antidepressants within a depressive episode, they are considered to have treatment resistant depression (TRD). Previous small randomised controlled trials suggested that pramipexole, a dopamine D2/3 receptor agonist, may be effective for treating patients with unipolar and bipolar depression as it is known to influence motivational drive and reward processing. PAX-D will compare the effects of pramipexole vs placebo when added to current antidepressant medication for people with TRD. Additionally, PAX-D will investigate the mechanistic effect of pramipexole on reward sensitivity using a probabilistic decision-making task.Methods and analysisPAX-D will assess effectiveness in the short- term (during the first 12 weeks) and in the longer-term (48 weeks) in patients with TRD from the UK. The primary outcome will be change in self-reported depressive symptoms from baseline to week 12 post-randomisation measured using the Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR16). Performance on the decision-making task will be measured at week 0, week 2 and week 12. Secondary outcomes include anhedonia, anxiety and health economic measures including quality of life, capability, well-being and costs. PAX-D will also assess the adverse effects of pramipexole including impulse control difficulties.DiscussionPramipexole is a promising augmentation agent for TRD and may be a useful addition to existing treatment regimes. PAX-D will assess its effectiveness and test for a potential mechanism of action in patients with TRD.Trial registration numberISRCTN84666271
Antipsychotic use in pregnancy and risk of attention/deficit-hyperactivity disorder and autism spectrum disorder: a Nordic cohort study
Authors: Hálfdánarson Óskar , Cohen Jacqueline M , Karlstad Øystein , Cesta Carolyn E , Bjørk Marte-Helene , Håberg Siri Eldevik , Einarsdóttir Kristjana , Furu Kari , Gissler Mika , Hjellvik Vidar , Kieler Helle , Leinonen Maarit K , Nørgaard Mette , Öztürk Esen Buket , Ulrichsen Sinna Pilgaard , Reutfors Johan , Zoega Helga 
Published: November 2021

BackgroundAntipsychotics are increasingly used among women of childbearing age and during pregnancy.ObjectiveTo determine whether children exposed to antipsychoticsin uteroare at increased risk of attention-deficit/hyperactivity disorder (ADHD) or autism spectrum disorder (ASD), accounting for maternal diagnoses of bipolar, psychotic and other psychiatric disorders.DesignPopulation-based cohort study, including a sibling analysis.SettingNationwide data on all pregnant women and their live-born singletons in Denmark (1997-2017), Finland (1996-2016), Iceland (2004-2017), Norway (2004-2017), and Sweden (2006-2016).Participants4 324 086 children were eligible for inclusion to the study cohort.InterventionAntipsychotic exposurein utero, assessed by pregnancy trimester, type of antipsychotic, and varying patterns of use.Main outcome measuresNon-mutually exclusive diagnoses of ADHD and ASD. We used Cox proportional hazard models to calculate hazard ratios (HRs) controlling for maternal psychiatric disorders and other potential confounding factors.FindingsAmong 4 324 086 singleton births, 15 466 (0.4%) were exposed to antipsychoticsin utero. During a median follow-up of 10 years, we identified 72 257 children with ADHD and 38 674 children with ASD. Unadjusted HRs were raised for both outcomes but shifted substantially towards the null after adjustment; 1.10 (95%CI 1.00 to 1.27) for ADHD and 1.12 (0.97 to 1.29) for ASD. Adjusted HRs remained consistent by trimester of exposure and type of antipsychotic. Comparingin uteroexposure with pre-pregnancy use yielded HRs of 0.74 (0.62 to 0.87) for ADHD and 0.88 (0.70 to 1.10) for ASD. Sibling analyses yielded HRs of 1.14 (0.79 to 1.64) for ADHD and 1.34 (0.75 to 2.39) for ASD.DiscussionOur findings suggest little or no increased risk of child ADHD or ASD afterin uteroexposure to antipsychotics.Clinical implicationsResults regarding child neurodevelopment are reassuring for women who need antipsychotics during pregnancy.
Quality of life after transcatheter or surgical aortic valve replacement using the Toronto Aortic Stenosis Quality of Life Questionnaire
Authors: Kennon Simon , Styra Rima , Bonaros Nikolaos , Stastny Lukas , Romano Mauro , Lefèvre Thierry , Di Mario Carlo , Stefàno Pierluigi , Ribichini Flavio Luciano , Himbert Dominique , Urena-Alcazar Marina , Salgado-Fernandez Jorge , Cuenca Castillo Jose Joaquin , Garcia Bruno , Deutsch Cornelia , Sykorova Lenka , Kurucova Jana , Thoenes Martin , Lüske Claudia , Bramlage Peter , Frank Derk 
Published: November 2021

BackgroundThe Toronto Aortic Stenosis Quality of Life Questionnaire (TASQ) is a validated instrument for assessing quality of life (QoL) in patients with severe aortic stenosis (AS). In this study, we evaluated health status outcomes, based on the TASQ, in patients with severe AS undergoing transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR).MethodsThe TASQ registry was a prospective observational registry. Patients with severe AS from nine centres in Europe and one in Canada underwent either SAVR or transfemoral TAVR. Patients completed the TASQ, Kansas City Cardiomyopathy Questionnaire and Short Form-12 V.2 prior to the intervention, predischarge, and at 30-day and 3-month follow-ups. Primary end point was the TASQ score.ResultsIn both the TAVR (n=137) and SAVR (n=137) cohorts, significant increases were observed in all three scores. The overall TASQ score improved as did all but one of the individual domains at 3 months after the intervention (p<0.001). TASQ health expectations were the only domain which worsened (p<0.001). Across TASQ subscores, significant changes were evident from the time of discharge in the TAVR and 30-day follow-up in the SAVR cohort. In a categorical analysis of the TASQ, 39.7% of the TAVR group and 35.0% of the SAVR group had a substantially improved health status at 3 months compared with baseline.ConclusionsThe TASQ captured changes in QoL among patients with severe AS who were treated with TAVR or SAVR. QoL improved substantially after either intervention, as indicated by changes in the TASQ overall score at 3 months.Trial registration numberNCT03186339.