bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prenatal exposure to nitrofurantoin and risk of childhood leukaemia: a registry-based cohort study in four Nordic countries
Authors: Hjorth Sarah , Pottegård Anton , Broe Anne , Hemmingsen Caroline H , Leinonen Maarit K , Hargreave Marie , Nörby Ulrika , Nordeng Hedvig 
Published: September 2021

Abstract

Background
Studies have suggested increased risks of childhood leukaemia after prenatal exposure to antibiotics, particularly nitrofurantoin. However, these findings may be related to the underlying maternal infection. This multinational study aimed to investigate the association between prenatal nitrofurantoin exposure and childhood leukaemia while accounting for maternal infection.

Methods
In a population-based cohort study of children born in Denmark, Finland, Norway or Sweden from 1997 to 2013, prenatal exposure to nitrofurantoin or pivmecillinam (active comparator) was ascertained from national Prescription Registries. Childhood leukaemia was identified by linkage to national Cancer Registries. Poisson regression was used to estimate incidence rate ratios (IRRs) and incidence rate differences (IRDs) with inverse probability of treatment weights applied to account for confounding.

Results
We included 44 091 children prenatally exposed to nitrofurantoin and 247 306 children prenatally exposed to pivmecillinam. The children were followed for 9.3 years on average (standard deviation 4.1). There were 161 cases of childhood leukaemia. The weighted IRR for prenatal nitrofurantoin exposure when compared with pivmecillinam was 1.34 (95% confidence interval 0.88, 2.06), corresponding to an IRD of 15 per million person-years. Higher point estimates were seen for first- and third-trimester exposure. There was no evidence of a dose–response relationship.

Conclusions
Prenatal exposure to nitrofurantoin was not substantially associated with childhood leukaemia, although a slightly elevated IRR with confidence intervals including the null was observed, corresponding to a small absolute risk. The lack of a dose–response relationship and a clear biological mechanism to explain the findings suggests against a causal association.
Foreign Policy Change from an Advocacy Coalition Framework Perspective
Authors: Haar Roberta N , Pierce Jonathan J 
Published: September 2021

AbstractWhy does a state change its foreign policy objectives and who is responsible for instigating such change? According to Hermann, four primary change agents are central to this process: leaders, bureaucracies, changes in domestic constituencies, and external shocks. This paper argues that the Advocacy Coalition Framework (ACF) is a complementary policy process framework that can explain foreign policy change (FPC) and that accounts for all four of these primary change agents. Additionally, it is a broader framework of the policy process that facilitates a more comprehensive understanding of the factors influencing FPC than traditional FPC research. The ACF has the potential to broaden our understanding of FPC by emphasizing the intersection of the international system with domestic politics and focusing on a myriad of policy actors coordinating their advocacy efforts to influence FPC. To support this argument, the paper discusses how FPC can benefit from the ACF and reviews past applications. It proposes a research agenda using the ACF to study FPC and draws conclusions about future challenges and directions.
Mating Disruption of the California Red Scale, Aonidiella aurantii (Hemiptera: Diaspididae) in Central California Citrus
Authors: Grafton-Cardwell E E , Leonard J T , Daugherty M P , Headrick D H 
Published: September 2021

Abstract
A warmer climate and the development of pesticide resistance have led to an increase in the number of generations and higher population densities of California red scale, Aonidella aurantii (Maskell) in central California. Commercial citrus orchard studies were conducted to determine how effective mating disruption using CheckMate CRS was at reducing A. aurantii. In 2016–2017, two replicated trials were conducted in 15.0–15.5 ha orchards and in 2018 and 2019, one half of each of 10 orchards 8–16.2 ha in size were treated with CheckMate CRS. Mating disruption significantly suppressed male captures for up to 8 mo. Average reductions of 90% in cumulative male flight trap catches were recorded, twig and leaf infestations were reduced by 95%, and highly scale-infested fruit were reduced by 75% in the CheckMate CRS plots for the 2018 and 2019 trials. In seven of 12 sites the percentage of highly infested fruit was reduced below 0.5%. Leaf and twig infestations in August and reductions in male captures during the 4th flight were strongly related to the percentage of highly infested fruit at the end of the season and could be used as predictors of the success of mating disruption. The results of the study indicated mating disruption using CheckMate CRS can be an effective method to reduce California red scale populations throughout the 4+ generations that occur in central California. Mating disruption has the potential to reduce or eliminate pesticide applications, especially in low scale density situations.
Research progress of the biosynthetic strains and pathways of bacterial cellulose
Authors: Li Guohui , Wang Li , Deng Yu , Wei Qufu 
Published: September 2021

AbstractBacterial cellulose is a glucose biopolymer produced by microorganisms and widely used as a natural renewable and sustainable resource in the world. However, few bacterial cellulose-producing strains and low yield of cellulose greatly limited the development of bacterial cellulose. In this review, we summarized the 30 cellulose-producing bacteria reported so far, including the physiological functions and the metabolic synthesis mechanism of bacterial cellulose, and the involved three kinds of cellulose synthases (type I, type II, and type III), which are expected to provide a reference for the exploration of new cellulose-producing microbes.
Phlebotominae Fauna (Diptera: Psychodidae) and Molecular Detection of Leishmania (Kinetoplastida: Trypanosomatidae) in Urban Caves of Belo Horizonte, Minas Gerais, Brazil
Authors: Serra e Meira Paula Cavalcante Lamy , Abreu Bruna Lacerda , de Almeida Zenóbio Ana Paula Lusardo , de Castilho Sanguinette Cristiani , Rêgo Felipe Dutra , de Lima Carvalho Gustavo Mayr , Saraiva Lara , Andrade Filho José Dilermando 
Published: September 2021

Abstract
Sand flies are often collected in urban areas, which has several implications for the risk of transmission of Leishmania Ross, 1903, to humans and other mammals. Given this scenario, we describe the sand fly fauna of caves and their surroundings in Mangabeiras Municipal Park (MMP) and Paredão Serra do Curral Park (PSCP), both located in the urban area of Belo Horizonte, Minas Gerais, Brazil, an endemic focus of visceral and cutaneous leishmaniasis. Collections were conducted monthly from November 2011 to October 2012, using CDC light traps exposed for two consecutive nights in four caves and their surroundings. Nonsystematized collections using Shannon traps and active searches were also performed around the caves. The presence of Leishmania DNA in collected female sand flies was evaluated by ITS1-PCR. A total of 857 sand flies representing fourteen species were collected in MMP, of which Evandromyia edwardsi (Mangabeira, 1941) was the most abundant. Leishmania amazonensis was detected in Brumptomyia nitzulescui (Costa Lima, 1932) and Ev. edwardsi, with the latter also having Leishmania braziliensis, Leishmania infantum, and Leishmania sp. A total of 228 sand flies representing four species were collected in PSCP, of which Sciopemyia microps (Mangabeira, 1942) was the most abundant. No females from PSCP were positive for Leishmania-DNA. Studies aimed at describing sand fly faunas of cave environments and detecting Leishmania are essential to understanding the relationship between these insects and this ecotope and assessing and monitoring areas that may pose risks to the health of visitors and employees.
Serum Amyloid A Is Present in Human Saccular Intracranial Aneurysm Walls and Associates With Aneurysm Rupture
Authors: Huuska Nora , Netti Eliisa , Tulamo Riikka , Lehti Satu , Jahromi Behnam Rezai , Kovanen Petri T , Niemelä Mika 
Published: September 2021

Abstract
Saccular intracranial aneurysm (sIA) rupture leads to a disabling subarachnoid hemorrhage. Chronic inflammation and lipid accumulation in the sIA wall contribute to wall degenerative remodeling that precedes its rupture. A better understanding of the pathobiological process is essential for improved future treatment of patients carrying sIAs. Serum amyloid A (SAA) is an acute-phase protein produced in response to acute and chronic inflammation and tissue damage. Here, we studied the presence and the potential role of SAA in 36 intraoperatively resected sIAs (16 unruptured and 20 ruptured), that had previously been studied by histology and immunohistochemistry. SAA was present in all sIAs, but the extent of immunopositivity varied greatly. SAA immunopositivity correlated with wall degeneration (p = 0.028) and rupture (p = 0.004), with numbers of CD163-positive and CD68-positive macrophages and CD3-positive T lymphocytes (all p &lt; 0.001), and with the expression of myeloperoxidase, matrix metalloproteinase-9, prostaglandin E-2 receptor, and cyclo-oxygenase 2 in the sIA wall. Moreover, SAA positivity correlated with the accumulation of apolipoproteins A-1 and B-100. In conclusion, SAA occurs in the sIA wall and, as an inflammation-related factor, may contribute to the development of a rupture-prone sIA.
Effects of biodiversity, stand factors and functional identity on biomass and productivity during the restoration of subtropical forests in Central China
Authors: Miao Wenhao , Ma Shupeng , Guo Zhiwen , Sun Haozhe , Wang Xuemei , Lyu Yueming , Wang Xiangping 
Published: September 2021

AbstractBiodiversity is found to have a significant promotion effect on ecosystem functions in manipulation experiments on grassland communities. However, its relative role compared with stand factors or functional identity is still controversial in natural forests. Here, we examined their relative effects on biomass and productivity during forest restoration. We investigated stand biomass and productivity for 24 plots (600 m2) across restoration stages in the subtropical forests of Mt. Shennongjia, Central China. We measured five key functional traits and calculated functional diversity (functional richness, evenness and dispersion) and community-weighted mean of traits. We used general linear models, variation partitioning methods to test the relative importance of stand factors (density, stand age, maximum height, etc.), functional identity, species and functional diversity on biomass and productivity. Our results illustrated that stand biomass and productivity increased significantly as forest restoration, and that community species richness increased, while functional dispersion decreased significantly. Variation partitioning analyses showed that diversity had no significant pure effects on biomass and productivity. However, diversity may affect biomass and productivity through the joint effect with stand factors and functional identity. Overall, we found that stand factors had the strongest effect on biomass and productivity, while functional identity significantly affects productivity but not biomass, suggesting that modulating stand structure and species identity are effective ways to enhance forest carbon storage and sequestrations potential in forest management.
Situation analysis of the pharmacovigilance system in Nepal using the indicator-based pharmacovigilance assessment tool (IPAT)
Authors: Jha Nisha , Palaian Subish , Shankar Pathiyil Ravi , K. C. Santosh , Kshetry Pan Bahadur 
Published: September 2021

Abstract

Objectives
The aim of this study was to assess the national and regional pharmacovigilance centres in Nepal in terms of their policy frameworks, structure and functioning.

Methods
A descriptive cross-sectional study was conducted during January 2021 among regional pharmacovigilance centres, and the national pharmacovigilance centre and the Ministry of Health and Population. The indicator-based pharmacovigilance assessment tool (IPAT) consisting of 43 indicators (26 core and 17 supplementary) assessing different aspects of pharmacovigilance was used.

Key findings
Of a total of 14 candidates representing regional pharmacovigilance centres, 12 agreed to participate. The national pharmacovigilance centre located at the Department of Drug Administration had an acceptable level of infrastructure and manpower but poor functioning and weak collaboration with regional centres. There are no policies and procedures specifically related to pharmacovigilance and no requirement for pharmaceutical companies to report adverse drug reactions (ADRs). The national centre received only 42 ADR reports during the evaluation period. The regional centres are mostly located (10 out of 14) in the Kathmandu Valley and had qualified manpower and basic resources. There were poor process indicators suggesting problems with functioning in terms of ADR reporting, signal generation and drug safety communication.

Conclusions
Underreporting of ADRs, weak processes and poor coordination among centres limit functioning of the system. Creating more awareness, involving consumers and pharmaceutical companies in the reporting process, and conducting more training programmes are needed for the proper functioning of pharmacovigilance services in Nepal.
Air travel-related outbreak of multiple SARS-CoV-2 variants
Authors: Dhanasekaran Vijaykrishna , Edwards Kimberly M , Xie Ruopeng , Gu Haogao , Adam Dillon C , Chang Lydia D J , Cheuk Sammi S Y , Gurung Shreya , Krishnan Pavithra , Ng Daisy Y M , Liu Gigi Y Z , Wan Carrie K C , Cheng Samuel S M , Tsang Dominic N C , Cowling Benjamin J , Peiris Malik , Poon Leo L M 
Published: September 2021

Abstract

Background
A large cluster of 59 cases were linked to a single flight with 146 passengers from New Delhi to Hong Kong in April 2021. This outbreak coincided with early reports of exponential pandemic growth in New Delhi, which reached a peak of &gt; 400 000 newly confirmed cases on 7 May 2021.

Methods
Epidemiological information including date of symptom onset, date of positive-sample detection and travel and contact history for individual cases from this flight were collected. Whole genome sequencing was performed, and sequences were classified based on the dynamic Pango nomenclature system. Maximum-likelihood phylogenetic analysis compared sequences from this flight alongside other cases imported from India to Hong Kong on 26 flights between June 2020 and April 2021, as well as sequences from India or associated with India-related travel from February to April 2021 and 1217 reference sequences.

Results
Sequence analysis identified six lineages of SARS-CoV-2 belonging to two variants of concern (Alpha and Delta) and one variant of public health interest (Kappa) involved in this outbreak. Phylogenetic analysis confirmed at least three independent sub-lineages of Alpha with limited onward transmission, a superspreading event comprising 37 cases of Kappa and transmission of Delta to only one passenger. Additional analysis of another 26 flights from India to Hong Kong confirmed widespread circulation of all three variants in India since early March 2021.

Conclusions
The broad spectrum of disease severity and long incubation period of SARS-CoV-2 pose a challenge for surveillance and control. As illustrated by this particular outbreak, opportunistic infections of SARS-CoV-2 can occur irrespective of variant lineage, and requiring a nucleic acid test within 72 hours of departure may be insufficient to prevent importation or in-flight transmission.
Maintaining osmotic balance in legume nodules
Authors: Poole Philip S , Ledermann Raphael 
Published: September 2021

This article comments on:Tian L, Liu L, Xu S, Deng R, Wu P, Jiang H, Wu G, Chen Y. 2022. A d-pinitol transporter, LjPLT11, regulates plant growth and nodule development in Lotus japonicus. Journal of Experimental Botany 73, 351–365.
AGN and star formation at cosmic noon: comparison of data to theoretical models
Authors: Florez Jonathan , Jogee Shardha , Guo Yuchen , Cora Sofía A , Weinberger Rainer , Davé Romeel , Hernquist Lars , Vogelsberger Mark , Ciardullo Robin , Finkelstein Steven L , Gronwall Caryl , Kawinwanichakij Lalitwadee , Leung Gene C K , LaMassa Stephanie , Papovich Casey , Stevans Matthew L , Wold Isak 
Published: September 2021

ABSTRACT
In theoretical models of galaxy evolution, active galactic nucleus (AGN) and star formation (SF) activity are closely linked and AGN feedback is routinely invoked to regulate galaxy growth. In order to constrain such models, we compare the hydrodynamical simulations IllustrisTNG and SIMBA, and the semi-analytical model SAG to the empirical results on AGN and SF at cosmic noon (0.75 &lt; z &lt; 2.25) reported in Florez et al. (2020). The empirical results are based on a large mass-complete sample drawn from 93 307 galaxies with and without high X-ray luminosity AGN (LX ≳ 1044 erg s−1), selected from a 11.8 deg2 area (∼0.18 Gpc3 comoving volume at z = 0.75–2.25). The main results of our comparisons are: (i) SAG and IllustrisTNG both qualitatively reproduce the empirical result that galaxies with high X-ray luminosity AGN have higher mean SFR, at a given stellar mass, than galaxies without such AGN. SAG, however, strongly overproduces the number density of high X-ray luminosity AGN by a factor of 10–100, while IllustrisTNG shows a lack of high X-ray luminosity AGN at high stellar mass ($M* \gt 10^{11} \, \mathrm{M}_{\odot }$) at z ∼ 2. (ii) In SIMBA, the mean SFR of galaxies with high X-ray luminosity AGN is lower than the SFR of galaxies without such AGN. Contrary to the data, many high X-ray luminosity AGN in SIMBA have quenched SF, suggesting that AGN feedback, or other feedback modes in galaxies with such AGN, might be too efficient in SIMBA.
Density estimation with Gaussian processes for gravitational wave posteriors
Authors: D’Emilio V , Green R , Raymond V 
Published: September 2021

ABSTRACTThe properties of black hole and neutron-star binaries are extracted from gravitational waves (GW) signals using Bayesian inference. This involves evaluating a multidimensional posterior probability function with stochastic sampling. The marginal probability distributions of the samples are sometimes interpolated with methods such as kernel density estimators. Since most post-processing analysis within the field is based on these parameter estimation products, interpolation accuracy of the marginals is essential. In this work, we propose a new method combining histograms and Gaussian processes (GPs) as an alternative technique to fit arbitrary combinations of samples from the source parameters. This method comes with several advantages such as flexible interpolation of non-Gaussian correlations, Bayesian estimate of uncertainty, and efficient resampling with Hamiltonian Monte Carlo.
On the terminal spins of accreting stars and planets: boundary layers
Authors: Dittmann Alexander J 
Published: September 2021

ABSTRACT
The origin of the spins of giant planets is an open question in astrophysics. As planets and stars accrete from discs, if the specific angular momentum accreted corresponds to that of a Keplerian orbit at the surface of the object, it is possible for planets and stars to be spun-up to near-break-up speeds. However, accretion cannot proceed on to planets and stars in the same way that accretion proceeds through the disc. For example, the magneto-rotational instability cannot operate in the region between the nearly Keplerian disc and more slowly rotating surface because of the sign of the angular velocity gradient. Through this boundary layer where the angular velocity sharply changes, mass and angular momentum transport is thought to be driven by acoustic waves generated by global supersonic shear instabilities and vortices. We present the first study of this mechanism for angular momentum transport around rotating stars and planets using 2D vertically integrated moving-mesh simulations of ideal hydrodynamics. We find that above rotation rates of ∼0.4−0.6 times the Keplerian rate at the surface the rate at which angular momentum is transported inwards through the boundary layer by waves decreases by ∼1−3 orders of magnitude depending on the gas sound speed. We also find that the accretion rate through the boundary layer decreases commensurately and becomes less variable for faster rotating objects. Our results provide a purely hydrodynamic mechanism for limiting the spins of accreting planets and stars to factors of a few less than the break-up speed.
The impact of the FMR and starburst galaxies on the (low metallicity) cosmic star formation history
Authors: Chruślińska Martyna , Nelemans Gijs , Boco Lumen , Lapi Andrea 
Published: September 2021

ABSTRACT
The question how much star formation is occurring at low metallicity throughout the cosmic history appears crucial for the discussion of the origin of various energetic transients, and possibly double black hole mergers. We revisit the observation-based distribution of birth metallicities of stars (fSFR(Z,z)), focusing on several factors that strongly affect its low metallicity part: (i) the method used to describe the metallicity distribution of galaxies (redshift-dependent mass metallicity relation – MZR, or redshift-invariant fundamental metallicity relation – FMR), (ii) the contribution of starburst galaxies and (iii) the slope of the MZR. We empirically construct the FMR based on the low-redshift scaling relations, which allows us to capture the systematic differences in the relation caused by the choice of metallicity and star formation rate (SFR) determination techniques and discuss the related fSFR(Z,z) uncertainty. We indicate factors that dominate the fSFR(Z,z) uncertainty in different metallicity and redshift regimes. The low metallicity part of the distribution is poorly constrained even at low redshifts (even a factor of ∼200 difference between the model variations) The non-evolving FMR implies a much shallower metallicity evolution than the extrapolated MZR, however, its effect on the low metallicity part of the fSFR(Z,z) is counterbalanced by the contribution of starbursts (assuming that they follow the FMR). A non-negligible fraction of starbursts in our model may be necessary to satisfy the recent high-redshift SFR density constraints.
The BIG X-ray tail
Authors: Ge Chong , Sun Ming , Yagi Masafumi , Fossati Matteo , Forman William , Jáchym Pavel , Churazov Eugene , Zhuravleva Irina , Boselli Alessandro , Jones Christine , Ji Li , Luo Rongxin 
Published: September 2021

ABSTRACT
Galaxy clusters grow primarily through the continuous accretion of group-scale haloes. Group galaxies experience preprocessing during their journey into clusters. A star-bursting compact group, the Blue Infalling Group (BIG), is plunging into the nearby cluster A1367. Previous optical observations reveal rich tidal features in the BIG members, and a long H α trail behind. Here, we report the discovery of a projected ∼250 kpc X-ray tail behind the BIG using Chandra and XMM–Newton observations. The total hot gas mass in the tail is ∼7 × 1010 M⊙ with an X-ray bolometric luminosity of ∼3.8 × 1041 erg s−1. The temperature along the tail is ∼1 keV, but the apparent metallicity is very low, an indication of the multi-T nature of the gas. The X-ray and H α surface brightnesses in the front part of the BIG tail follow the tight correlation established from a sample of stripped tails in nearby clusters, which suggests the multiphase gas originates from the mixing of the stripped interstellar medium (ISM) with the hot intracluster medium (ICM). Because thermal conduction and hydrodynamic instabilities are significantly suppressed, the stripped ISM can be long lived and produce ICM clumps. The BIG provides us a rare laboratory to study galaxy transformation and preprocessing.