bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protein intake in inhabitants with regular exercise is associated with sleep quality: Results of the Shika study
Authors: Suzuki Fumihiko , Morita Emi , Miyagi Sakae , Tsujiguchi Hiromasa , Hara Akinori , Nguyen Thao Thi Thu , Shimizu Yukari , Hayashi Koichiro , Suzuki Keita , Kannon Takayuki , Tajima Atsushi , Matsumoto Sumire , Ishihara Asuka , Hori Daisuke , Doki Shotaro , Oi Yuichi , Sasahara Shinichiro , Satoh Makoto , Matsuzaki Ichiyo , Yanagisawa Masashi , Ikaga Toshiharu , Nakamura Hiroyuki 
Published: February 2021

Study objectives
Although associations between sleep quality and environmental factors and nutrient intake have been reported, interactions between these factors have not been elucidated in detail. Therefore, this cross-sectional study examined the effects of regular exercise and nutrient intake on sleep quality using the Pittsburgh Sleep Quality Index (PSQI), which is the most frequently used index for sleep evaluation.

Methods
The participants included 378 individuals aged 40 years or older living in Shika Town, Ishikawa Prefecture. Of these individuals, 185 met the inclusion criteria. The participants completed a self-administered questionnaire assessing lifestyle habits and frequency and duration of exercise, the PSQI, and the brief-type self-administered diet history questionnaire (BDHQ) on nutrient intake.

Results
A two-way analysis of covariance on regular exercise and PSQI scores indicated that protein intake (17.13% of energy) was significantly higher in the regular exercise and PSQI ≤10 groups than in the non-regular exercise or PSQI ≥11 groups (p = 0.002). In a multiple logistic regression analysis with PSQI scores (≤10 and ≥11), protein intake was a significant independent variable in any of the models adjusted for confounding factors such as age, sex, body mass index, current smoker, and current drinker (OR: 1.357, 95% CI: 1.081, 1.704, p = 0.009) in the regular exercise group but not in the non-regular exercise group.Conclusions
We identified a positive relationship between sleep quality and protein intake in the regular exercise group. These findings suggest that regular exercise at least twice a week for 30 minutes or longer combined with high protein intake contributes to good sleep quality.
Cardiac-specific troponins in uncomplicated pregnancy and pre-eclampsia: A systematic review
Authors: Dockree Samuel , Brook Jennifer , Shine Brian , James Tim , Green Lauren , Vatish Manu 
Published: February 2021

Background
The risk of myocardial infarction (MI) increases during pregnancy, particularly in women with pre-eclampsia. MI is diagnosed by measuring high blood levels of cardiac-specific troponin (cTn), although this may be elevated in women with pre-eclampsia without MI, which increases diagnostic uncertainty. It is unclear how much cTn is elevated in uncomplicated and complicated pregnancy, which may affect whether the existing reference intervals can be used in pregnant women. Previous reviews have not investigated high-sensitivity troponin in pregnancy, compared to older, less sensitive methods.

Methods
Electronic searches using the terms “troponin I” or “troponin T”, and “pregnancy”, “pregnancy complications” or “obstetrics”. cTn levels were extracted from studies of women with uncomplicated pregnancies or pre-eclampsia.

Results
The search identified ten studies with 1581 women. Eight studies used contemporary methods that may be too insensitive to use reliably in this clinical setting. Two studies used high-sensitivity assays, with one reporting an elevation in troponin I (TnI) in pre-eclampsia compared to uncomplicated pregnancy, and the other only examining women with pre-eclampsia.
Seven studies compared cTn between women with pre-eclampsia or uncomplicated pregnancy using any assay. Seven studies showed elevated TnI in pre-eclampsia compared to uncomplicated pregnancy or non-pregnant women. One study measured troponin T (TnT) in pregnancy but did not examine pre-eclampsia.

Conclusion
TnI appears to be elevated in pre-eclampsia, irrespective of methodology, which may reflect the role of cardiac stress in this condition. TnI may be similar in healthy pregnant and non-pregnant women, but we found no literature reporting pregnancy-specific reference intervals using high-sensitivity tests. This limits broader application of cTn in pregnancy. There is a need to define reference intervals for cTn in pregnant women, which should involve serial sampling throughout pregnancy, with careful consideration for gestational age and body mass index, which cause dynamic changes in normal maternal physiology.
Impact of the COVID-19 pandemic on the lifestyle, mental health, and quality of life of adults in South Korea
Authors: Park Kang-Hyun , Kim Ah-Ram , Yang Min-Ah , Lim Seung-Ju , Park Ji-Hyuk 
Published: February 2021

ObjectiveThe COVID-19 pandemic continues to pose significant challenges to nations. The Korean government aimed to mitigate the spread of COVID-19 through stay-at-home strategies and maintaining social distance, which are likely to result in major changes in the lifestyle, mental health, and quality of life of citizens. This study aimed to investigate the impact of the COVID-19 pandemic on these factors in Koreans over 20 years old.MethodsThe study sample consisted of 104 adults in South Korea aged over 20 years. An online survey was conducted between August and October 2020, in which participants were asked to complete the Yonsei Lifestyle Profile to assess lifestyle changes, the Center for Epidemiological Studies-Depression Scale, and the World Health Organization Quality of Life Scale abbreviated version. To investigate the changes in people’s lifestyles, depression, and quality of life post COVID-19, descriptive statistics were calculated for these indicators before and after the onset of the pandemic. The p-value was two-sided, and values <0.05, were regarded as statistically significant.ResultsThere was a significant decline in physical and other meaningful activities, including activities of daily living, leisure, social activity, and education. However, there were no significant changes in nutrition, except in the consumption of carbohydrates and minerals. Participants reported that their quality of life and mental health had decreased after the pandemic struck.ConclusionsWe obtained novel data on the changes in the lifestyle, mental health, and quality of life of South Korean adults before and after the onset of the pandemic. The results of our study may assist health policymakers and practitioners in the development of health education or relevant interventions to deal with the pandemic situation as well as future crises.
Cost-Effectiveness Analysis of Antiviral Therapy for Untreated Minimally Active Chronic Hepatitis B to Prevent Liver Disease Progression
Authors: Lee Hankil , Kim Beom Kyung , Jang Sungin , Ahn Sang Hoon 
Published: February 2021

INTRODUCTION:
Antiviral therapy (AVT) for chronic hepatitis B (CHB) can prevent liver disease progression. Because of its stringent reimbursement criteria, significant numbers of patients with untreated minimally active (UMA)-CHB exist, although they are still subject to disease progression. We thus performed a cost-effectiveness analysis to assess the rationale for AVT for UMA-CHB.

METHODS:
We compared cost and effectiveness (quality-adjusted life years, QALYs) in virtual UMA-CHB cohorts of 10,000 50-year-olds receiving AVT (scenario 1) vs no treatment (scenario 2) for 10 years. A Markov model, including 7 health states of CHB-related disease progression, was used. Values for transition probabilities and costs were mostly obtained from recent South Korean data.

RESULTS:
The simulation of AVT vs no treatment predicted $2,201 incremental costs and 0.175 incremental QALYs per patient for 10 years, with an incremental cost-effectiveness ratio (ICER) of $12,607/QALY, suggesting cost-effectiveness of AVT. In sum, if 10,000 patients received AVT, 720 incident hepatocellular carcinoma and 465 CHB-related more deaths could be averted in 10 years relative to no treatment. When the simulated analysis period was extended to 20 years, AVT was also highly cost-effective with an ICER of $2,036/QALY. Although hepatocellular carcinoma–related mortality was a major factor influencing ICER, its fluctuation can be accepted within willingness to pay of $33,000 in South Korea. According to probabilistic sensitivity analysis with the threshold of willingness to pay, the probability of AVT cost-effectiveness was 83.3%.

DISCUSSION:
Long-term AVT for patients with UMA-CHB may contribute positively toward individual clinical benefit and national health care budget.
Organspende – Liebe zum Nächsten oder Verantwortung für das Ganze?
Authors: Meyer-Magister Hendrik 
Published: February 2021

Abstract
In the debates on post-mortal organ donation German protestant churches fundamentally argue in favour of the motif of Christian charity: To donate organs after death must be a voluntary act of giving. Any duties to do so are incompatible with this motif. In principle Christian charity focuses on a concrete other, whose specific needs in a given situation are apparent. Against this backdrop the article argues, that charity is an insufficient motif in these debates, since anonymous post-mortal organ donation structurally deals with a generalised other. Therefore, it seems more appropriate to understand organ donation as an expression of the individual’s orientation towards the common weal and as a matter of responsibility for the whole of society. Indeed: there is no individual duty to donate organs after death, but a demand for personal reasoning and public participation in a crucial social and political question, that seems well in line with the concept of Public Protestantism.
Kantian Themes in Merleau-Ponty’s Theory of Perception
Authors: Matherne Samantha 
Published: February 2021

Abstract:
It has become typical to read Kant and Merleau-Ponty as offering competing approaches to perceptual experience. Kant is interpreted as an ‘intellectualist’ who regards perception as conceptual ‘all the way out’, while Merleau-Ponty is seen as Kant’s challenger, who argues that perception involves non-conceptual, embodied ‘coping’. In this paper, however, I argue that a closer examination of their views of perception, especially with respect to the notion of ‘schematism’, reveals a great deal of historical and philosophical continuity between them. By analyzing Kant’s theory of schematism, the interpretation of it by the Neo-Kantian Pierre Lachièze-Rey, and Merleau-Ponty’s theory of the body schema, we find that aspects of Merleau-Ponty’s theory of perception are better understood as a development of Kant’s theory of perception.
A Role for STOML3 in Olfactory Sensory Transduction
Authors: Agostinelli Emilio , Gonzalez-Velandia Kevin Y. , Hernandez-Clavijo Andres , Kumar Maurya Devendra , Xerxa Elena , Lewin Gary R. , Dibattista Michele , Menini Anna , Pifferi Simone 
Published: February 2021

AbstractStomatin-like protein-3 (STOML3) is an integral membrane protein expressed in the cilia of olfactory sensory neurons (OSNs), but its functional role in this cell type has never been addressed. STOML3 is also expressed in dorsal root ganglia neurons, where it has been shown to be required for normal touch sensation. Here, we extended previous results indicating that STOML3 is mainly expressed in the knob and proximal cilia of OSNs. We additionally showed that mice lacking STOML3 have a morphologically normal olfactory epithelium. Because of its presence in the cilia, together with known olfactory transduction components, we hypothesized that STOML3 could be involved in modulating odorant responses in OSNs. To investigate the functional role of STOML3, we performed loose patch recordings from wild-type (WT) andStoml3knock-out (KO) OSNs. We found that spontaneous mean firing activity was lower with additional shift in interspike intervals (ISIs) distributions inStoml3KOs compared with WT neurons. Moreover, the firing activity in response to stimuli was reduced both in spike number and duration in neurons lacking STOML3 compared with WT neurons. Control experiments suggested that the primary deficit in neurons lacking STOML3 was at the level of transduction and not at the level of action potential generation. We conclude that STOML3 has a physiological role in olfaction, being required for normal sensory encoding by OSNs.
The GARP Domain of the Rod CNG Channel's β1-Subunit Contains Distinct Sites for Outer Segment Targeting and Connecting to the Photoreceptor Disk Rim
Authors: Pearring Jillian N. , Martínez-Márquez Jorge , Willer Jason R. , Lieu Eric C. , Salinas Raquel Y. , Arshavsky Vadim Y. 
Published: February 2021

Vision begins when light is captured by the outer segment organelle of photoreceptor cells in the retina. Outer segments are modified cilia filled with hundreds of flattened disk-shaped membranes. Disk membranes are separated from the surrounding plasma membrane, and each membrane type has unique protein components. The mechanisms underlying this protein sorting remain entirely unknown. In this study, we investigated the outer segment delivery of the rod cyclic nucleotide-gated (CNG) channel, which is located in the outer segment plasma membrane, where it mediates the electrical response to light. UsingXenopusand mouse models of both sexes, we now show that the targeted delivery of the CNG channel to the outer segment uses the conventional secretory pathway, including protein processing in both ER and Golgi, and requires preassembly of its constituent α1 and β1 subunits. We further demonstrate that the N-terminal glutamic acid-rich protein (GARP) domain of CNGβ1 contains two distinct functional regions. The glutamic acid-rich region encodes specific information targeting the channel to rod outer segments. The adjacent proline-enriched region connects the CNG channel to photoreceptor disk rims, likely through an interaction with peripherin-2. These data reveal fine functional specializations within the structural domains of the CNG channel and suggest that its sequestration to the outer segment plasma membrane requires an interaction with peripherin-2.SIGNIFICANCE STATEMENTNeurons and other differentiated cells have a remarkable ability to deliver and organize signaling proteins at precise subcellular locations. We now report that the CNG channel, mediating the electrical response to light in rod photoreceptors, contains two specialized regions within the N terminus of its β-subunit: one responsible for delivery of this channel to the ciliary outer segment organelle and another for subsequent channel sequestration into the outer segment plasma membrane. These findings expand our understanding of the molecular specializations used by neurons to populate their critical functional compartments.
Consonance Preferences Within an Unconventional Tuning System
Authors: Friedman Ronald S. , Kowalewski Douglas A. , Vuvan Dominique T. , Neill W. Trammell 
Published: February 2021

Recently, Bowling, Purves, and Gill (2018a), found that individuals perceive chords with spectra resembling a harmonic series as more consonant. This is consistent with their vocal similarity hypothesis (VSH), the notion that the experience of consonance is based on an evolved preference for sounds that resemble human vocalizations. To rule out confounding between harmonicity and familiarity, we extended Bowling et al.’s (2018a) procedure to chords from the unconventional Bohlen-Pierce chromatic just (BPCJ) scale. We also assessed whether the association between harmonicity and consonance was moderated by timbre by presenting chords generated from either piano or clarinet samples. Results failed to straightforwardly replicate this association; however, evidence of a positive correlation between harmonicity and consonance did emerge across timbres following post hoc exclusion of chords containing intervals that were particularly similar to conventional equal-tempered dyads. Supplementary regression analyses using a more comprehensive measure of harmonicity confirmed its positive association with consonance ratings of BPCJ chords, yet also showed that spectral interference independently contributed to these ratings. In sum, our results are consistent with the VSH; however, they also suggest that a composite model, incorporating both harmonicity as well as spectral interference as predictors, would best account for variance in consonance judgments.
Hybrid Electric Vehicles: A mini Overview
Authors: Muhammad Aisha , Haruna Ibrahim Shanono 
Published: February 2021

The present greenhouse effect and its arrays of limitations on energy sources have made Hybrid Electric Vehicles (HEV’s) a current research focus due to its reduced amount of fuel usage. The ability to simultaneously deliver power to the wheels from the mo-tor/engine made HEVs to have greater advantages (less fuel consumption and reduced internal combustion engine size without compromising the power output) over the tradi-tional vehicles. Despite its low patronage in markets, there is still hope that its popularity in the market will rise due to the superior qualities associated with it. This paper presented an brief review of Hybrid Electric Vehicles, by focusing on history, architecture and energy sources.
Model Satisfaction Users Measurement of Academic Information System Using End-User Computing Satisfaction (EUCS) Method
Authors: Hidayah Nur Aeni , Fetrina Elvi , Taufan Alvali Zaqi 
Published: February 2021

As concrete steps in order to realize the vision and mission of an organization or educational institution is to implement the system of academic information. The one factor that influences the success of the academic information system is the satisfaction of users. The problems in the user satisfaction are also issues that cannot be denied and continue to be studied. In consequently, having measurements related to user satisfaction is required. This research is done to see how the user satisfaction of the existing system has been implemented and to know what factorshas influenced the system. The method used in this study is a quantitative method using the End User Computing Satisfaction (EUCS) model whereas 255 respondents are chosen as the sample for the study. The purposive sampling technique is usedand the PLS-SEM approach with tools Smart PLS 3.0 is used for analyzing the data. This research consists of 7 hypotheses and 8 variables, namely Content, Accuracy, Format, Timeliness, Ease of Use, System Reliability, System Speed and End-User Satisfaction. The research finds out that the current level of end-user satisfaction is in satisfied level. Inferentially, of the 7 hypotheses tested, 2 of them were rejected and the other 5; Accuracy, System Reliability, Timeliness, Content and System Spee;are accepted.Through this research, it is hoped that later it could be used as a practical consideration and theoretical study in thefuture.
Primary cutaneous mucinous carcinoma of axilla: a case report with review of literature
Authors: Kamat Sanjivi , Malawad Manohar , Patil Rajesh 
Published: February 2021

Primary cutaneous mucinous carcinoma is a low grade tumour of the sweat gland rarely occurring in middle aged men, more commonly in the sixth decade. When seen in a younger age group, the tumour tends to be more aggressive with potential for metastasis. Clinical presentation is usually a hard nodular well defined painless lesion confined to skin and subcutaneous tissue, commonly seen in head and neck region. Histopathological examination of the specimen shows cells with myxoid and mucinous material, confirmed by immunohistochemistry showing positive for estrogens and progesterone receptor and cytokeratin 7, is diagnostic. Surgery is the treatment of choice, wide local excision with margin of 1 cm as this tumor is resistant to radiotherapy and chemotherapy. Its tendency for late recurrences and rare metastasis, adds to the good prognosis. With rare chances of distant metastasis, prognosis remains good but local recurrences are not uncommon after excision.
EPIDEMIOLOGIA DA HANSENÍASE E A DESCENTRALIZAÇÃO DAS AÇÕES DE CONTROLE NO BRASIL
Authors: Rodrigues Rayssa Nogueira , Arcêncio Ricardo Alexandre , Lana Francisco Carlos Felix 
Published: February 2021

<span>Objetivo: Analisar a situação epidemiológica da hanseníase no Brasil e sua associação com a descentralização das ações de controle. Método: Estudo ecológico misto com dados secundários do Sistema de Informação de Agravos de Notificação dos municípios brasileiros. Foi utilizado </span><span>o modelo de regressão binomial negativo, período 2001-2015</span><span>. Resultados: A análise das variações geográficas e temporais mostrou comportamentos heterogêneos dos indicadores epidemiológicos de hanseníase, sendo que o </span><span>aumento significativo destes foi associado </span><span>à</span><span> </span><span>proporção de casos de hanseníase diagnosticados na Atenção Primária à Saúde; já a proporção da </span><span>cobertura populacional estimada por </span><span>Estratégia Saúde da Família foi associada somente à redução significativa do indicador taxa de detecção de hanseníase entre os menores de quinze anos de idade. </span><span>Conclusão:</span><span> Apesar da expansão da Estratégia Saúde da Família ser importante, a condição identificada como fundamental para o controle da doença é o aumento da oferta de ações pelos profissionais de saúde.</span>
Geração de cenários através de simulação computacional como instrumento da mobilidade urbana
Authors: Silva Fernando Dutra , Falcão Viviane Adriano , Evangelista Antônio Carlos 
Published: February 2021

O aumento significativo da frota de veículos no Brasil acarretou algumas externalidades urbanas, há algumas, porém que tem uma influência direta na qualidade de vida da população economicamente ativa, que são os congestionamentos. O objetivo desse estudo foi estabelecer a otimização semafórica na região do entorno do Hospital de Clínicas da Universidade Federal do Triângulo Mineiro (HC-UFTM) em Uberaba e a partir disso promover melhorias na mobilidade urbana do entorno. Para tanto, foi feito uma contagem volumétrica em cinco interseções no entorno do HC-UFTM e, posteriormente a caracterização das mesmas de acordo com dois manuais desenvolvidos pelos DNIT e CONTRAN. Os dados coletados foram inseridos no software Traffic Software Integrator System – TSIS 6, e processados considerando o cenário atual e as propostas de melhoria. Na análise dos cenários, conseguiu-se uma melhoria no desempenho de todos os parâmetros considerados, mais especificamente aumentou a taxa de movimento e a velocidade média de deslocamento e uma diminuição média da fila máxima de veículos nas interseções. Os resultados encontrados foram validados considerando o cenário atual e para os cenários otimizados, algumas medidas simples como alteração do tempo de ciclo podem otimizar o fluxo de veículos na região.