bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microvascular Reconstruction of Osteonecrosis: Assessment of Long‐term Quality of Life
Authors: Sweeny Larissa , Mayland Erica , Swendseid Brian P. , Curry Joseph M. , Kejner Alexandra E. , Thomas Carissa M. , Kain Joshua J. , Cannady Steve B. , Tasche Kendall , Rosenthal Eben L. , DiLeo Michael , Luginbuhl Adam J. , Theeuwen Hailey , Sarwary Juliana R. , Petrisor Daniel , Wax Mark K. 
Published: February 2021

ObjectiveReview long‐term clinical and quality‐of‐life outcomes following free flap reconstruction for osteonecrosis.Study DesignRetrospective multi‐institutional review.SettingTertiary care centers.MethodsPatients included those undergoing free flap reconstructions for osteonecrosis of the head and neck (N = 232). Data included demographics, defect, donor site, radiation history, perioperative management, diet status, recurrence rates, and long‐term quality‐of‐life outcomes. Quality‐of‐life outcomes were measured using the University of Washington Quality of Life (UW‐QOL) survey.ResultsOverall flap success rate was 91% (n = 212). Relative to preoperative diet, 15% reported improved diet function at 3 months following reconstruction and 26% at 5 years. Osteonecrosis recurred in 14% of patients (32/232); median time to onset was 11 months. Cancer recurrence occurred in 13% of patients (29/232); median time to onset was 34 months. Results from the UW‐QOL questionnaire were as follows: no pain (45%), minor or no change in appearance (69%), return to baseline endurance level (37%), no limitations in recreation (40%), no changes in swallowing following reconstruction (28%), minor or no limitations in mastication (29%), minor or no speech difficulties (93%), no changes in shoulder function (84%), normal taste function (19%), normal saliva production (27%), generally excellent mood (44%), and no or minimal anxiety about cancer (94%).ConclusionThe majority of patients maintained or had advancement in diet following reconstruction, with low rates of osteonecrosis or cancer recurrence and above‐average scores on UW‐QOL survey suggesting good return of function and quality of life.
National Trends in Opioid Prescriptions Following Outpatient Otologic Surgery, 2005‐2017
Authors: Cooperman Shayna P. , Jin Michael C. , Qian Z. Jason , Alyono Jennifer C. 
Published: February 2021

ObjectiveTo describe opioid stewardship in ambulatory otologic surgery from 2005 to 2017.Study DesignDescriptive study of US private insurance claims.SettingNationwide deidentified private insurance claims database (Clinformatics DataMart; Optum).MethodsA total of 17,431 adult opioid‐naïve outpatients were included in the study. Patients were identified from CPT‐4 codes (Current Procedural Terminology, Fourth Edition) as having undergone middle ear or mastoid surgery. Multiple regression was used to determine sociodemographic and geographic predictors of postoperative morphine milligram equivalents (MMEs) prescribed, including procedure type, year of procedure, age, sex, education, income level, and geographic region of the United States.ResultsThe mean prescribed perioperative dose over the examined period was 203.03 MMEs (95% CI, 200.27‐205.79; 5‐mg hydrocodone pill equivalents, 40.61). In multivariate analysis, patients undergoing mastoid surgery were prescribed more opioids than those undergoing middle ear surgery (mean difference, 39.89 MME [95% CI, 34.37‐45.41], P <. 01; 5‐mg hydrocodone pill equivalents, 8.0). Men were prescribed higher doses than women (mean difference, 15.39 [95% CI, 9.87‐20.90], P <. 01; 5‐mg hydrocodone pill equivalents, 3.1). Overall MMEs prescribed by year demonstrates a sharp drop in MMEs from 2015 to 2017.ConclusionWhile the amount of opioids prescribed perioperatively has declined in recent years, otologists should continue to be cognizant of potential overprescribing in light of previous studies of patients’ relatively low opioid intake.
Determinants of normal nutrition among 0–59-month-old Filipino children living in low-income households
Authors: Ramirez Ma. Anna Rita , Ducay Apple Joy 
Published: February 2021

Background: An alternative concept in understanding malnutrition among 0 to 59-month-old children from low-income households is to look at and understand factors contributing to their good nutritional status. Aim: (a) Compared nutritional status of children across age groups in terms of weight-for-age, length/height-for-age, weight-for-length/height and body mass index-for-age z scores; (b) determined and compared selected characteristics of children and mothers across age; (c) identified factors affecting normal nutritional status of these children. Methods: Cross-sectional data from the Philippines' 8th National Nutrition Survey among 1,990 children. Differences in mean values measured using analysis of variance; chi-square test for assessing significance of association between children with normal nutritional status across child and maternal characteristics; and multivariate logistic regression to calculate adjusted odds ratio (AORs). Results: Younger (AOR =1.63–2.54), female children (AOR=1.20), mothers neither pregnant nor lactating (AOR=1.18), have high school, vocational (AOR=1.65) or college level education (AOR=2.02), household use of water-sealed toilet (AOR=1.26), having nuclear family types (AOR=1.25) indicated protection against undernutrition. Behavior-related factors that significantly predict normal nutrition among the children were “acceptable” food consumption score among households (0 to 5 and 6 to 23 months old), delivery in health facilities (6 to 23 months old) and household use of water-sealed toilets (24 to 59 months). Conclusion: Based on the findings, activities and programs can be tailored around the behavior-related factors identified depending on the target age group, and pursued in crafting interventions to maintain normal nutrition among the children.
Bortezomib-based therapy in non-transplant multiple myeloma patients: a retrospective cohort study from the FABIO project
Authors: Franchi Matteo , Vener Claudia , Garau Donatella , Kirchmayer Ursula , Di Martino Mirko , Romero Marilena , De Carlo Ilenia , Scondotto Salvatore , Stival Chiara , Della Porta Matteo Giovanni , Passamonti Francesco , Corrao Giovanni 
Published: February 2021

Introduction: Randomized clinical trials showed that bortezomib, in addition to conventional chemotherapy, improves survival and disease progression in multiple myeloma (MM) patients not eligible for stem cell transplantation. The aim of this retrospective population-based cohort study is the evaluation of both clinical and economic profile of bortezomib-based versus conventional chemotherapy in daily clinical practice. Methods: Healthcare utilization databases of six Italian regions were used to identify adult patients with non-transplant MM, who started a first-line therapy with bortezomib-based or conventional chemotherapy. Patients were matched by propensity score and were followed from treatment start until death, lost to follow-up or study end-point. Overall survival (OS) and restricted mean survival time (RMST) were estimated using the Kaplan–Meier method. Association between first-line treatment and risk of death was estimated by a conditional Cox proportional regression model. Average mean cumulative costs were estimated and compared between groups. Results: In the period 2010–2016, 3509 non-transplant MM patients met the inclusion criteria, of which 1157 treated with bortezomib-based therapy were matched to 1826 treated with conventional chemotherapy. Median OS and RMST were 33.9 and 27.9 months, and 42.9 and 38.4 months, respectively, in the two treatment arms. Overall, these values corresponded to a HR of death of 0.79 (95% CI 0.71–0.89) over a time horizon of 84 months. Average cumulative cost were 83,839 € and 54,499 €, respectively, corresponding to an incremental cost-effectiveness ratio of 54,333 € per year of life gained, a cost coherent with the willingness-to-pay thresholds frequently adopted from Western countries. Conclusions: These data suggested that, in a large cohort of non-transplant MM patients treated outside the experimental setting, first-line treatment with bortezomib-based therapy was associated with a favourable effectiveness and cost-effectiveness profile.
A case of an intramural, cavitated feline gastrointestinal eosinophilic sclerosing fibroplasia of the cranial abdomen in a domestic longhair cat
Authors: Davidson Gordon A , Taylor Samantha S , Dobromylskyj Melanie J , Gemignani Francesco , Renfrew Helen 
Published: February 2021

Case summary A 5-year-old neutered male domestic longhair cat was presented for the investigation of a cranial abdominal mass following a 1-month history of inappetence and lethargy. Abdominal ultrasound revealed a large cavitated mass confluent with the mesenteric aspect of the descending duodenum. At surgery, the mass was found to involve the pylorus, proximal duodenum and pancreas, and was non-resectable. Histopathological examination of surgical biopsies revealed a non-neoplastic process involving eosinophils and fibroplasia. Relevance and novel information This case report describes an uncommon feline gastrointestinal pathology with an unusual appearance that may provide an additional differential diagnosis other than neoplasia or abdominal abscess when confronted with a cavitated abdominal mass in cats.
Perinatal Mood and Anxiety Disorder Management in Multicenter Community Practices: Clinicians’ Training, Current Practices and Perceived Strategies to Improve Future Implementation
Authors: Puspitasari Ajeng J. , Heredia Dagoberto , Weber Elise , Betcher Hannah K , Coombes Brandon J. , Brodrick Ellen M. , Skinner Susan M. , Tomlinson Angie L. , Salik Shana S. , Allen Summer V. , O’Grady Jason S. , Johnson Emily K. , L’amoureux Tayler M. , Moore Katherine M. 
Published: February 2021

Background: This study aimed to explore clinicians’ perspectives on the current practice of perinatal mood and anxiety disorder (PMAD) management and strategies to improve future implementation. Methods: This study had a cross-sectional, descriptive design. A 35-item electronic survey was sent to clinicians (N = 118) who treated perinatal women and practiced at several community clinics at an academic medical center in the United States. Results: Among clinicians who provided care for perinatal women, 34.7% reported never receiving PMAD management training and 66.3% had less than 10 years of experience. Out of 10 patients who reported psychiatric symptoms, 47.8% of clinicians on average reported providing PMAD management to 1 to 3 patients and 40.7% noted that they conducted screening only when patient expresses PMAD symptoms. Suggested future improvements were providing training, developing a referral list, and establishing integrated behavioral health services. Conclusions: Results from this study indicated that while PMAD screening and management was implemented, improvements are warranted to meet established guidelines. Additionally, clinicians endorsed providing PMAD management to a small percentage of perinatal patients. Suggested strategies to increase adoption and implementation of PMAD management should be explored to improve access to behavioral health services for perinatal women.
Implementing a Geriatric Fracture Program in a Mixed Practice Environment Reduces Total Cost and Length of Stay
Authors: Lin Carol , Rosen Sonja , Breda Kathleen , Tashman Naomi , T. Black Jeanne , Lee Jae , Chiang Aaron , Rosen Bradley 
Published: February 2021

Introduction: Geriatric-orthopaedic co-management models can improve patient outcomes. However, prior reports have been at large academic centers with “closed” systems and an inpatient geriatric service. Here we describe a Geriatric Fracture Program (GFP) in a mixed practice “pluralistic” environment that includes employed academic faculty, private practice physicians, and multiple private hospitalist groups. We hypothesized GFP enrollment would reduce length of stay (LOS), time to surgery (TTS), and total hospital costs compared to non-GFP patients. Materials and Methods: A multidisciplinary team was created around a geriatric Nurse Practitioner (NP) and consulting geriatrician. Standardized geriatric focused training programs and electronic tools were developed based on best practice guidelines. Fracture patients >65 years old were prospectively enrolled from July 2018 – June 2019. A trained biostatistician performed all statistical analyses. A p < 0.05 was considered significant. Results: 564 operative and nonoperative fractures in patients over 65 were prospectively followed with 153 (27%) enrolled in the GFP and 411 (73%) admitted to other hospitalists or their primary care provider (non-GFP). Patients enrolled in the GFP had a significantly shorter median LOS of 4 days, compared to 5 days in non-GFP patients (P < 0.001). There was a strong trend towards a shorter median TTS in the GFP group (21.5 hours v 25 hours, p = 0.066). Mean total costs were significantly lower in the GFP group ($25,323 v $29085, p = 0.022) Discussion: Our data shows that a geriatric-orthopaedic co-management model can be successfully implemented without an inpatient geriatric service, utilizing the pre-existing resources in a complex environment. The program can be expanded to include additional groups to improve care for entire geriatric fracture population with significant anticipated cost savings. Conclusions: With close multidisciplinary team work, a successful geriatric-orthopaedic comanagement model for geriatric fractures can be implemented in even a mixed practice environment without an inpatient geriatrics service.
The impact of out-of-home placement characteristics with regard to suicidal risk among adult survivors of childhood abuse
Authors: Touati Camille Danner , Miljkovitch Raphaële , Sirparanta Aino , Deborde Anne-Sophie 
Published: February 2021

Background: Childhood abuse is associated with increased lifetime suicidal risk (SR). Among victims of abuse, children in out-of-home care are also at risk. Out-of-home placement is aimed at stopping further exposure to maltreatment and at providing the necessary security for proper development. Research suggests that placement arrangements may impact children’s mental health outcomes. Objective: The study was aimed at examining (1) the direct effects of different placement characteristics (i.e. age at first placement, number of placements, placement disruptions, total time in care, contact with biological parents, contact with siblings, placement with siblings) on SR and (2) whether these characteristics moderate the link between maltreatment and SR. Participants: The sample consisted of 77 adults (52 women; 25 men; mean age: 26.6 years) who received out-of-home care during childhood. Method: Participants completed the Childhood Trauma Questionnaire and the Mini International Neuropsychiatric Interview (for SR). Participants’ records were used to determine placement characteristics and maltreatment. Results: PLS-PM analyses suggest a significant role of risk (age at first placement, number of placements, placement disruptions, contact with biological parents) and protective factors (contact with siblings, foster home placement) on SR. Risk factors also moderate the link between maltreatment and SR. Conclusions: Interventions aimed at limiting risk factors during placement seem important to reduce SR.
STING and transplantation: can targeting this pathway improve outcomes?
Authors: Bader Cameron S. , Jin Lei , Levy Robert B. 
Published: February 2021

Abstract
Stimulator of interferon genes (STING) is an innate immune sensor of cytoplasmic dsDNA originating from microorganisms and host cells. STING plays an important role in the regulation of murine graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and may be similarly activated during other transplantation modalities. In this review, we discuss STING in allo-HSCT and its prospective involvement in autologous HSCT (auto-HSCT) and solid organ transplantation (SOT), highlighting its unique role in nonhematopoietic, hematopoietic, and malignant cell types.
Heightened activation of embryonic megakaryocytes causes aneurysms in the developing brain of mice lacking podoplanin
Authors: Hoover Christopher , Kondo Yuji , Shao Bojing , McDaniel Michael J. , Lee Robert , McGee Samuel , Whiteheart Sidney , Bergmeier Wolfgang , McEver Rodger P. , Xia Lijun 
Published: February 2021

Abstract
During early embryonic development in mammals, including humans and mice, megakaryocytes (Mks) first originate from primitive hematopoiesis in the yolk sac. These embryonic Mks (eMks) circulate in the vasculature with unclear function. Herein, we report that podoplanin (PDPN), the ligand of C-type lectin-like receptor (CLEC-2) on Mks/platelets, is temporarily expressed in neural tissue during midgestation in mice. Loss of PDPN or CLEC-2 resulted in aneurysms and spontaneous hemorrhage, specifically in the lower diencephalon during midgestation. Surprisingly, more eMks/platelets had enhanced granule release and localized to the lower diencephalon in mutant mouse embryos than in wild-type littermates before hemorrhage. We found that PDPN counteracted the collagen-1–induced secretion of angiopoietin-1 from fetal Mks, which coincided with enhanced TIE-2 activation in aneurysm-like sprouts of PDPN-deficient embryos. Blocking platelet activation prevented the PDPN-deficient embryo from developing vascular defects. Our data reveal a new role for PDPN in regulating eMk function during midgestation.
Ontology-guided segmentation and object identification for developmental mouse lung immunofluorescent images
Authors:   LungMAP Consortium, Masci Anna Maria , White Scott , Neely Ben , Ardini-Polaske Maryanne , Hill Carol B. , Misra Ravi S. , Aronow Bruce , Gaddis Nathan , Yang Lina , Wert Susan E. , Palmer Scott M. , Chan Cliburn 
Published: February 2021

AbstractBackgroundImmunofluorescent confocal microscopy uses labeled antibodies as probes against specific macromolecules to discriminate between multiple cell types. For images of the developmental mouse lung, these cells are themselves organized into densely packed higher-level anatomical structures. These types of images can be challenging to segment automatically for several reasons, including the relevance of biomedical context, dependence on the specific set of probes used, prohibitive cost of generating labeled training data, as well as the complexity and dense packing of anatomical structures in the image. The use of an application ontology helps surmount these challenges by combining image data with its metadata to provide a meaningful biological context, modeled after how a human expert would make use of contextual information to identify histological structures, that constrains and simplifies the process of segmentation and object identification.ResultsWe propose an innovative approach for the semi-supervised analysis of complex and densely packed anatomical structures from immunofluorescent images that utilizes an application ontology to provide a simplified context for image segmentation and object identification. We describe how the logical organization of biological facts in the form of an ontology can provide useful constraints that facilitate automatic processing of complex images. We demonstrate the results of ontology-guided segmentation and object identification in mouse developmental lung images from the Bioinformatics REsource ATlas for the Healthy lung database of the Molecular Atlas of Lung Development (LungMAP1) programConclusionWe describe a novel ontology-guided approach to segmentation and classification of complex immunofluorescence images of the developing mouse lung. The ontology is used to automatically generate constraints for each image based on its biomedical context, which facilitates image segmentation and classification.
Mapping and validation of a major QTL for primary root length of soybean seedlings grown in hydroponic conditions
Authors: Chen Huatao , Kumawat Giriraj , Yan Yongliang , Fan Baojie , Xu Donghe 
Published: February 2021

Abstract
Background
The root system provides nutrient absorption and is closely related to abiotic stress tolerance, but it is difficult to study the roots under field conditions. This study was conducted to identify quantitative trait loci (QTL) associated with primary root length (PRL) during soybean seedling growth in hydroponic conditions. A total of 103 F7 recombinant inbred lines (RILs) derived from a cross between K099 (short primary root) and Fendou 16 (long primary root) were used to identify QTL for PRL in soybean. The RIL population was genotyped with 223 simple sequence repeats markers covering 20 chromosomes. Phenotyping for primary root length was performed for 3-weeks plants grown in hydoponic conditions. The identified QTL was validated in near isogenic lines and in a separate RIL population.

Results
QTL analysis using inclusive composite interval mapping method identified a major QTL on Gm16 between SSR markers Sat_165 and Satt621, explaining 30.25 % of the total phenotypic variation. The identified QTL, qRL16.1, was further confirmed in a segregating population derived from a residual heterozygous line (RHLs-98). To validate qRL16.1 in a different genetic background, QTL analysis was performed in another F6 RIL population derived from a cross between Union (medium primary root) and Fendou 16, in which a major QTL was detected again in the same genomic region as qRL16.1, explaining 14 % of the total phenotypic variation for PRL. In addition, the effect of qRL16.1 was confirmed using two pair of near-isogenic lines (NILs). PRL was significantly higher in NILs possessing the qRL16.1 allele from Fendou 16 compared to allele from K099.

Conclusions
The qRL16.1 is a novel QTL for primary root length in soybean which provides important information on the genetic control of root development. Identification of this major QTL will facilitate positional cloning and DNA marker-assisted selection for root traits in soybean.
Impact of a visual indicator on the noise level in an emergency medical dispatch centre - a pilot study
Authors: Outrey Justin , Pretalli Jean-Baptiste , Pujol Sophie , Brembilla Alice , Desmettre Thibaut , Lambert Christophe , Labourey Jean-Marc , Mauny Frédéric , Khoury Abdo 
Published: February 2021

Abstract
Background
Noise levels are monitored in call centres. A maximum of 52 to 55 dB(A) is recommended in order to prevent adverse events. We aimed at assessing the noise level and the impact of a visual noise indicator on the ambient noise level in a French Regional Emergency Medical Dispatch Centre (EMDC).

Methods
We conducted an observational study in the EMDC of the SAMU25 (University Hospital of Besancon). We measured the noise level using a SoundEarII® noise indicator (Dräger Medical SAS, France). The measurement took place in two phases on three consecutive days from 00:00 to 11:59 PM. At baseline, phase 1, the device recorded the average ambient noise for each minute without visual indication. Secondly, phase 2 included a sensor mounted with a light that would turn on green if noise was below 65 dB(A), orange if noise ever exceeded 65 and red if it exceeded 75 dB(A).

Results
In the presence of the visual noise indicator, the LAeq was significantly lower than in the absence of visual noise indicator (a mean difference of − 4.19 dB; P < 10–3). It was higher than 55 dB(A) in 84.9 and 43.9% of the time in phases 1 and 2, respectively.

Conclusions
The noise levels were frequently higher than the standards, and sometimes close to recommended limits, requiring preventive measures. The noise indicator had a positive effect on the ambient noise level. This work will allow the implementation of effective prevention solutions and, based on future assessments, could improve operators’ well-being and better care for patient.