bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Efficacy of a Commercial Physical Activity Monitor in Longitudinal Tracking of Pulmonary Hypertension Patients
Authors: Rosenzweig Eliana H , Villeda Gerson Antonio Valencia , Crook Sarah , Koli Fatima , Rosenzweig Erika B. , Krishnan Usha S. 
Published: December 2021

Abstract
Patients with pulmonary arterial hypertension (PAH) have quality of life (QoL) limitations, decreased exercise capacity, and poor prognosis if left untreated. Standard exercise testing is routinely performed for the evaluation of patients with PAH but may be limited in its ability to monitor activity levels in daily living. We evaluated the validity of the commercial Fitbit Charge HR as a tool to assess real time exercise capacity as compared to standard exercise testing in patients with PAH. Ambulatory pediatric and adult PAH patients were enrolled and given a Fitbit with instructions to continuously wear during waking hours. Subjects underwent a 6-minute walk test (6MWT), cardiopulmonary exercise test (CPET) and an SF-36 QoL survey on the day of enrollment and follow-up. Twenty-seven ambulatory subjects with PH were enrolled and 21 had sufficient data for analyses (median age 25, range 13-59, 14 F) were enrolled. Daily steps measured by the Fitbit had a positive correlation with 6MWT distance (r = 0.72, p = 0.03) and an inverse correlation with WHO functional class. On the QoL survey, 77% reported improvement in energy/fatigue (p = 0.055). At follow up there was a strong correlation between Fitbit steps and role limitations due to physical problems (r = 0.88, p = 0.020) and weaker correlations with less related QoL markers. These findings suggest activity monitors may have potential as a simple/novel method of assessing longitudinal exercise capacity and activity levels in PAH patients. Further study in larger cohorts of patients is warranted to determine the best accelerometric correlates with outcomes.
Reactivation of Crohn’s colitis in an adolescent following serial autologous fecal transplants for diversion colitis: A case report with multiomic characterization
Authors: Polanco Esthermari Gonzalez , Murach Maria , Hoffman Casandra L , Oliphant Sandra L. , Wase Nishikant , McGowan Emily C. , Mendoza Michael V. , Moore Sean R. 
Published: December 2021

Abstract
Autologous fecal transplant (AFT, transfer of ileostomy feces to the colon) for diversion colitis (DC) has not yet been described in children or adolescents. We performed serial AFTs in a 16-year-old with Crohn’s disease and DC. As evidenced by endoscopic, histologic, laboratory, and multiomic profiling of the colon, the first AFT led to interval improvement in DC, whereas the second AFT reactivated Crohn’s colitis. These findings ultimately guided shared decision-making towards total colectomy.
Influence of Freeze-Thaw on the Stability of Road Cut Slopes near Atal Tunnel in Indian Himalayan Region
Authors: Sardana Sahil , Sinha Rabindra Kumar , Verma A. K. , Jaswal Mamta , Singh T.N. 
Published: December 2021

Abstract
The rock slopes in the Indian Himalayan region are exposed to recurrent freeze-thaw. Freeze-thaw plays a dominant role in the instability of rock slopes in cold regions. Extensive field investigations have been carried on the two rock slopes of the Solang valley roadway in Himachal Pradesh. Freeze-thaw testing has been carried out in the laboratory on the rock samples collected from the studied slopes. The test has been repeated for 30 freeze-thaw cycles. The laboratory tests have been conducted to determine the mechanical properties of rock with and without freeze-thaw conditioning. The micro-photographs from scanning electron microscope have been obtained to identify the microscopic damages due to freeze-thaw activity. The macroscopic damages have been recognized in tensile, compressive and triaxial compressive strength of rock. Further, a three-dimensional numerical analysis has been performed to evaluate the stability and corroborate the results with the field observations. FT conditioning results reveal a reduction of about 27–39 % in rock strength and subsequently a decrease in the factor of safety by 10–39 % for rock slopes.
Encapsulated Allogeneic Synovial Membrane Mesenchymal Stem Cells Provide Better Outcomes of Chondral Lesions in Horses
Authors: Santos Vitor Hugo , Pfeifer João Pedro Hübbe , Rosa Gustavo dos Santos , Stievani Fernanda de Castro , Apolonio Emanuel Vitor Pereira , Rossi Mariana Correa , Constantino Leonel Vinicius , de Melo Thadeu Rodrigues , Fonseca-Alves Carlos Eduardo , Alves Ana Liz Garcia 
Published: December 2021

Abstract
Osteoarthritis is the main cause of equine lameness, and its treatment remains ineffective. Synovial membrane mesenchymal stem cells (SMMSCs) provide satisfactory outcomes in joint injuries, mainly due to their immunomodulatory and reparative properties. This study aimed to evaluate the effect of SMMSCs, either encapsulated in alginate hydrogel or free, in chondral lesions of horses.Methods: Chondral lesions were surgically induced in the medial trochlea of the talus of fifteen horses. Animals were treated with PBS free SMMSCs or encapsulated SMMSCs. Physical evaluations, assignment of lameness scores and synovial fluid analysis were performed (cytological analysis and dosage of IL-1, IL-10, IL-6, INF-Ɣ, TNF 𝛼, P substance, serum amyloid A, TGF-β, IGF and PGE2) for two weeks. Cartilage biopsies were performed 150 days after induction for histological analysis and immunohistochemistry staining.Results: All groups initially presented inflammation. Although free SMMSCs showed moderate tissue repair, encapsulated SMMSCs had a lower grade of inflammation with superior tissue macro- and microscopic aspects at the end, while the control group showed fibrosis and poor cartilage aspect. This study suggests better effectiveness of stem cells in chondral defects when encapsulated MSCs are used.Conclusion: While the absence of treatment perpetuates cartilage degradation, encapsulated SMMSCs respond better to initial inflammation, interacting and modulating the environment through the release of anti-inflammatory cytokines. Better outcomes observed in encapsulated MSCs were related to the immuno- and physical barriers provided by the alginate hydrogel, allowing a longer period of permanence and interaction between MSCs and the environment.
Interpreting models interpreting brain dynamics
Authors: Rahman Md Mahfuzur , Mahmood Usman , Lewis Noah , Gazula Harshvardhan , Fedorov Alex , Fu Zening , Calhoun Vince , Plis Sergey 
Published: December 2021

Abstract
Brain dynamics are highly complex and yet hold the key to understanding brain function and dysfunction. The dynamics captured by resting-state functional magnetic resonance imaging data are noisy, high-dimensional, and not readily interpretable. The typical approach of reducing this data to low-dimensional features and focusing on the most predictive features comes with strong assumptions and can miss essential aspects of the underlying dynamics. In contrast, introspection of discriminatively trained deep learning models may uncover disorder-relevant elements of the signal at the level of individual time points and spatial locations. Yet, the difficulty of reliable training on high-dimensional low sample size datasets and the unclear relevance of the resulting predictive markers prevent the widespread use of deep learning in functional neuroimaging. In this work, we introduce a deep learning framework to learn from high-dimensional dynamical data while maintaining stable, ecologically valid interpretations. Results successfully demonstrate that the proposed framework enables learning the dynamics of resting-state fMRI directly from small data and capturing compact, stable interpretations of features predictive of function and dysfunction.
Spatial Pattern and Determinants of Institutional Delivery in Ethiopia: Spatial and Multilevel Analysis Using 2019 Ethiopian Mini Demographic and Health Survey.
Authors: Awol Mukemil , Edosa Dejene , Jemal kemal 
Published: December 2021

Abstract
Background: In Ethiopia, despite the progress that has been made to improve maternal and child health, the proportion of births occurring at health institutions is still very low (26%), Which significantly contribute to a large number of maternal death 412 deaths/100,000 live births. Therefore, this study intended to determine spatial pattern and factors affecting institutional delivery among women who had live birth in Ethiopia within five years preceding survey.Method: Data from 2019 Ethiopian mini demographic and health survey were used. Taking into account the nested structure of the data, multilevel logistic regression analysis has been employed to a nationally representative sample of 5753 women nested with in 305 communities/clusters.Result: A significant heterogeneity was observed between clusters for institutional delivery which explains about 57% of the total variation. Individual-level variables: primary education (OR= 1.8: 95% CI: 1.44-2.26), secondary education (OR= 3.65: 95% CI: 2.19- 6.1), diploma and higher (OR= 2.74: 95% CI: 1.02 – 7.34), women who had both Radio and Television were 4.6 times (OR= 4.6; 95% CI: 2.52, 8.45), four and above Antenatal visit (AOR=2.72 ,95% CI:2.2, 3.34), rich wealth index (OR= 2.22; 95% CI: 1.62- 2.99), birth interval for 18 to 33 months (OR= 1.8; 95% CI: 1.19, 2.92), and women who space birth for 33 and above months (OR= 2.02; 95% CI: 1.3, 3.12) were associated with institutional delivery. Community level variables, community high proportion of antenatal visit (OR= 4.68; 95% CI: 4.13- 5.30), and Region were associated with institutional deliveryConclusion: A clustered pattern of areas with low institutional delivery was observed in Ethiopia. Both individual and community level factors found significantly associated with institutional delivery theses showed the need for community women education through health extension programs and community health workers. And the effort to promote institutional delivery should pay special attention to antenatal care, less educated women and interventions considering awareness, access, and availability of the services are vital for regions.
Optimized Data-Independent Acquisition Approach for Proteomic Analysis at Single-Cell Level
Authors: Wang Yuefan , Lih Tung-Shing Mamie , Chen Lijun , Xu Yuanwei , Kuczler Morgan D. , Cao Liwei , Pienta Kenneth J. , Amend Sarah R. , Zhang Hui 
Published: December 2021

Abstract
Background: Single-cell proteomic analysis provides valuable insights into cellular heterogeneity allowing the characterization of the cellular microenvironment which is difficult to accomplish in bulk proteomic analysis. Currently, single-cell proteomic studies utilize data-dependent acquisition (DDA) mass spectrometry (MS) coupled with a TMT labelled carrier channel. Due to the extremely imbalanced MS signals among the carrier channel and other TMT reporter ions, the quantification is compromised. Thus, data-independent acquisition (DIA)-MS should be considered as an alternative approach towards single-cell proteomic study since it generates reproducible quantitative data. However, there are limited reports on the optimal workflow for DIA-MS-based single-cell analysis. Methods: We report an optimized DIA workflow for single-cell proteomics using Orbitrap Lumos Tribrid instrument. We utilized a breast cancer cell line (MDA-MB-231) and induced drug resistant polyaneuploid cancer cells (PACCs) to evaluate our established workflow. Results: We found that a short LC gradient was preferable for peptides extracted from single cell level with less than 2 ng sample amount. The total number of co-searching peptide precursors was also critical for protein and peptide identifications at nano- and sub-nano-gram levels. Post-translationally modified peptides could be identified from a nano-gram level of peptides. Using the optimized workflow, up to 1,500 protein groups were identified from a single PACC corresponding to 0.2 ng of peptides. Furthermore, about 200 peptides with phosphorylation, acetylation, and ubiquitination were identified from global DIA analysis of 100 cisplatin resistant PACCs (20 ng). Finally, we used this optimized DIA approach to compare the whole proteome of MDA-MB-231 parental cells and induced PACCs at a single-cell level. We found the single-cell level comparison could reflect real protein expression changes and identify the protein copy number. Conclusions: Our results demonstrate that the optimized DIA pipeline can serve as a reliable quantitative tool for single-cell as well as sub-nano-gram proteomic analysis.
Analysis of environmental hazards in the system «children's playground – urbanized area»
Authors: Stadnik Veronika 
Published: December 2021

The article presents the results of the study of environmental pollution by methods of biological indication. The objects of research are children's playgrounds which are influenced by the negative anthropogenic factors. A child's body is more vulnerable to anthropogenic stresses. Car exhaust gases can have a negative impact on the respiratory, cardiovascular, nervous and other systems. Excessive noise pollution not only affects your hearing, but also other organs and systems. In addition, noise can increase stress hormone levels. The aim of the study is to identify the main adverse factors affecting playgrounds in large cities. Despite there are the sanitary standards for the placement of playgrounds in large cities, it was found that about 50 % of all playgrounds were located in violation of environmental safety standards. As part of the work, an inventory of children's playgrounds and sports grounds in the cities of Kyiv, Kharkiv and Dnipro was carried out. The author carried out experimental research on some playgrounds using biological indication methods. The method of lichen indication revealed that four out of ten playgrounds in Kharkiv have a high level of air pollution, and two out of ten in Kyiv and Dnipro. This is confirmed by the biotesting method. It was found that one of the methods of solving the problem of excessive anthropogenic load on the objects of study is planting greenery. It is experimentally established that green plantations are able to reduce the level of noise pollution by 4–6 dB and absorb pollutants. In addition to reducing the anthropogenic load, the greening of playgrounds has an impact on improving the microclimate of the urban environment, and developing the visual qualities of urbanised landscapes
Nanostructure reveals REE mineral crystallization mechanisms in granites from a heavy REE deposit, South China
Authors: Shi Aiguo , Xu Cheng , Chakhmouradian Anton R. , Smith Martin P. , Kynicky Jindrich , Fan Chaoxi , Wei Chunwan , Kuang Guangxi 
Published: December 2021

Abstract
Weathering crusts after granites are the most important source of heavy rare-earth elements (HREE) worldwide. Although HREE in these deposits is known to be inherited from parental rocks, the origin of HREE enrichment and the reasons why it is rare outside of China remains unclear. Here, we report the occurrence of variably organized nanoparticles of Ce-poor (&lt;0.2 wt%), Nd-Y-rich bastnäsite-(La), and associated cerianite in parental granites from a HREE deposit, South China. The mineral contains high-HREE abundances (up to 13 wt% Y2O3). Synchrotron radiation-induced X-ray diffraction and high-resolution transmission electron microscopy analyses suggest that the mineral grew as disordered nanocrystals and (nearly) coaligned nanoparticle aggregations, thus supporting “nonclassical” crystallization mechanisms by particle attachment under hydrothermal conditions. The nanocrystal-line Ce-poor, Nd-Y-rich bastnäsite-(La) precipitated at rapidly decreasing temperature related to the influx of externally derived fluids, which caused CO2-H2O immiscibility and REE supersaturation. This interpretation is supported by petrographic data and microthermometric analysis of fluid inclusions in quartz. Unusually high fO2 resulted in Ce oxidation and decoupling from trivalent lanthanides, producing polycrystalline mineralization.
The Category of “responsibility” in the Humanities and Law: A Multidisciplinary Approach
Authors: Sushchenko Volodymyr 
Published: December 2021

The article is devoted to the theoretical foundations of the category of “responsibility” of philosophy and ethics, as well as its interpretation in psychology and jurisprudence. The author analyzes the category of “responsibility” in the context of etymology (origin) of this term in Ukrainian, Russian, English, French and German languages, while emphasizing their semantic similarity/identity. On the base of the analysis of scientific sources, an attempt was made to take a multidisciplinary approach to the interpretation of this category in jurisprudence in order to better and The article is devoted to the theoretical foundations of the category of “responsibility” of philosophy and ethics, as well as its interpretation in psychology and jurisprudence. The author analyzes the category of “responsibility” in the context of etymology (origin) of this term in Ukrainian, Russian, English, French and German languages, while emphasizing their semantic similarity/identity. On the base of the analysis of scientific sources, an attempt was made to take a multidisciplinary approach to the interpretation of this category in jurisprudence in order to better and
Chihuahua-Sacramento and Tabalaopa-Aldama aquifers of Chihuahua state, Mexico: linkage and importance of geostatistical and hydrogeochemical analysis
Authors: Núñez J. , Herrera E. , Navarro C. J. 
Published: December 2021

Abstract
The objective of this study is to gather sufficient information to make a diagnosis of drinking water sufficiency in the Chihuahua-Sacramento and Tabalaopa-Aldama aquifers. By applying advanced statistical techniques, the goal is to find the variables that control the regional and intermediate flow systems and establish the characteristics of a heterogeneous aquifer. The variables chosen from those established were as follows: total solids (TS), nitrates (NO3), fluoride (F), and total hardness, among others. In order to establish a conceptual model, the results from all the sampling were carried out by the National Water Commission (CONAGUA) in the aforementioned aquifers and were used to obtain an approximate flow differentiation. The results showed a good flow differentiation. In addition, a group of mixed water was detected among the intermediate and regional flows. The increase in the average regional flow values suggests a rise in the incidence of an upward flow of the regional flow as a result of uncontrolled extraction.
In Vitro Fatigue and Fracture Load of Monolithic Ceramic Crowns Supported by Hybrid Abutment
Authors: Nawafleh Noor , Elshiyab Shareen , Öchsner Andreas , George Roy 
Published: December 2021

Objective:
This study evaluated the performance of zirconia and lithium disilicate crowns supported by implants or cemented to epoxy resin dies.

Methods:
Eigthy zirconia and lithium disilicate crowns each were prepared and assigned in four groups according to the crown material and supporting structure combinations (implant-supported zirconia, die-supported zirconia, implant-supported lithium disilicate, and die-supported lithium disilicate). Ten crowns in each group acted as control while the rest (n=10) underwent thermocycling and fatigue with 100 N loading force for 1.5 million cycles. Specimens were then loaded to fracture in a universal testing machine. Data were analysed using one-way ANOVA and Tukey multiple comparison test with a 95% level of significance.

Results:
No implants or crown failure occurred during fatigue. The mean fracture load values (control, fatigued) in newton were as follows: (4054, 3344) for implant-supported zirconia, (3783, 3477) for die-supported zirconia, (2506, 2207) for implant-supported lithium disilicate, and (2159, 1806) for die-supported lithium disilicate. Comparing the control with the corresponding fatigued subgroup showed a significantly higher fracture load mean of the control group in all cases. Zirconia showed a significantly higher fracture load mean than lithium disilicate (P=0.001, P<0.001). However, comparing crowns made from the same material according to the supporting structure showed no significant difference (P=0.923, P=0.337).

Conclusion:
Zirconia and lithium disilicate posterior crowns have adequate fatigue and fracture resistance required for posterior crowns. However, when heavy fatigue forces are expected, zirconia material is preferable over lithium disilicate. Zirconia and lithium disilicate implant-supported crowns cemented to hybrid abutments should have satisfactory clinical performance.
Is Dental Panoramic Radiography Reliable to Assess Position of Bicortical Fixation Screws in Mandibular Fractures? Case Report
Authors: Albassal Ahmad , Al-Khanati Nuraldeen Maher , Harfouch Munir 
Published: December 2021

Background:
Panoramic radiography is widely used as a diagnostic tool before oral surgeries and can be considered the foremost follow-up image after. It provides a broad observation of the maxillomandibular complex at a lower cost and radiation dose. But cone-beam computed tomography (CBCT) examination, after panoramic radiograph evaluation, can produce a change in the diagnostic thinking of maxillofacial surgeons leading to alterations in treatment plans.

Objective:
We aim to report a case with incidentally discovered radiographic findings where diagnostic changes were caused by switching from panoramic to CBCT imaging.

Conclusion:
Radiographic assessment of the position and angulation of screws by panoramic x-ray should be approached with extreme caution. The image of choice is CBCT if nerve injury is suspected.
Comparison of Surface Equivalent Dose in CBCT, Digital Panoramic and Intra-Oral X-Ray Generators Using InstadoseTM Device: An In-Vitro Study
Authors: Mathew Asok , Almahi Salam , Mohamed Razan , Abu Fanas Salem , Jaber Mohamed A. , Luke Alexander M. , Radeideh Ahmed , Shetty Shishir 
Published: December 2021

Background:
Radiation protection in the dental examination is often overlooked because the doses delivered are negligible. However, the volume of dental radiological examinations will constitute almost 15% of all the radiological examinations carried out in the medical field.

Aim:
This study aims to evaluate and compare the surface equivalent dose on various target organs from various radiology devices on the RINN phantom, and the effect of numerous scanning protocols on said dose using dosimetry badge (Instadose).

Objectives:
The main objective is to study surface equivalent doses delivered in various critical organ regions in the facial region with the help of an Instadose device and to compare the doses delivered between 2D programs against 3D programs.

Materials and Methods:
RINN phantom was mounted on a dental chair for use against Planmeca ProMax 3D Classic and Planmeca intraoral ProX. Models. An Instadose badge was placed on various anatomical landmarks, and radiographic exposure protocols were applied to vary the parameters. The equivalent dose was calculated by connecting the dosimeter to a laptop and performing an instant reading output on the Instadose software.

Results:
The Thyroid showed a mean of 0.350, 0.0000, 0.0133, and 0.0000 in response to exposure by intraoral machine ProX, Panoramic, CBCT, and CBCT in ULD mode respectively. The dose absorbed by the left salivary glands was found to be significantly lower than the right salivary glands in panoramic exposures.

Conclusion:
It was revealed that a significant reduction in the dose when applying the Ultra-Low Dose protocol was noticed, and it reached up to 100% in the thyroid. It was also noted that there is no need for a thyroid collar in CBCT and Panoramic exposures. Maintaining the KVp at a constant and the exposure time as a variant caused a change in the dose equivalent received by the floor of the mouth and the right salivary gland.