bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research Capabilities of Public Secondary School Teachers in the Schools Division of Zambales
Authors: Farin Elizabeth N. , Brade Wilma M. , Garcia Cherry E. 
Published: August 2021

The study aimed to assess the research capability of public secondary school teachers in the Division of Zambales and utilized a descriptive research design with a questionnaire as the main instrument in gathering data from seven hundred (700) teacher-respondents who were randomly selected. The researcher found out that the respondent is a married female Teacher-I in her early adulthood, with 21-25 hours of teaching load, baccalaureate degree holder had no research conducted and published but had attended a school-based seminar on research with knowledge on basic computer applications. The respondents were assessed "moderately capable" of writing a research proposal and writing a research report. There is significant differences in civil status, academic rank, specialization, number of seminars attended, number of research published, and the level of computer literacy towards writing research proposal while the significant difference in age, specialization, number of seminars attended number of research published, and the level of computer literacy towards writing a research report. There is a slight or weak relationship between the number of research conducted and the research capability and a negligible relationship between the number of seminars attended and the research capability as to writing a research proposal and writing a research report.
Intensitas Serangan Hama Dan Patogen Pada Bibit Tembakau (Nicotiana tabaccum L.) Di Dinas Pangan Pertanian Kelautan Dan Perikanan Kota Langsa
Authors: Harlita Harlita 
Published: August 2021

Tanaman tembakau merupakan salah satu komoditas andalan Indonesia yang berperan penting dalam penyediaan lapangan pekerjaan, sumber pendapatan bagi petani, dan sumber devisa negara bagi negara. Namun akhir-khir ini produktivitas mengalami penerunan yang di sebabkan serangan hama, patogen, gulma, dan faktor lingkungan. Tujuan dari penelitian ini yaitu mengetahui jenis hama dan patogen yang menyerang pada fase pembibitan tembakau, mengetahui persentase serangan hama dan patogen dan mengetahui cara pengendalian hama dan patogen pada pembibitan tembakau di Dinas Pangan Pertanian Kelautan dan Perikanan Kota Langsa. Metode yang digunakan pada penelitian ini yaitu metode diskriptif kuantitatif dengan mengidentifikasi dan mengitung persentase dan insentisitas serangan hama dan patogen yang menyerang tanaman tembakau di pembibitan Dinas Pangan Pertanian Kelautan dan Perikanan Kota Langsa. Berdasarkan hasil penelitian terdapat dua jenis hama dan patogen yang menyerang tanaman tembakau pada fase pembibitan yaitu ulat daun (Spodoptera litura) dan jamur (Phytophthora nicotianae). Intensitas serangan hama dan patogen tertinggi pada hari ke-1 pengamatan terdapat pada Plot ke-I yaitu 0,25 % dan 0, 56 %, sedangkan terendah pada Plot ke IV yaitu 0,12 dan 0,25%. Namun, pada hari ke 15 setelah aplikasi fungisida nordox 70 ml/14 liter air dan insektisida decis 2,5 gr/15 intensitas serangan hama dan patogen mengalami penurunan yang signifikan. Dengan demikian fungisida nordox dan insektisida decis efektif mengendalikan hama dan patogen yang menyerang tanaman tembakau pada fase pembibitan.
Effect of device-guided paced breathing of biofeedback on blood pressure, stress and anxiety levels in hypertensives
Authors: New York Beatriz Souza de Albuquerque Cacique , Nascimento Micaele Farias , Moraes Alexa Alves de , Leite Jéssica Costa , Souza Iara Tainá Cordeiro de , Fernandes Ana Tereza do Nascimento Sales Figueiredo 
Published: August 2021

The present study aimed to evaluate the influence of cardiac coherence through Biofeedback Therapy (BT) with paced breathing on blood pressure, stress and anxiety levels in individuals with essential arterial hypertension. The participants underwent 8 sessions of paced breathing guided by biofeedback visual therapy for 20 minutes, in which they were evaluated through clinical assessment, Hamilton Anxiety Rating Scale, Perceived Stress Scale and cardiovascular variables. Comparisons of means were performed using the paired and unpaired Student's t-test. Statistically significant correlations were considered when p ≤ 0.05 with a 95% confidence interval. The effect size (Cohen's d) and common language effect size were calculated to assess the effect of such therapy. Sixteen patients with mean age of 57.3 ± 14 years old participated in this study. Comparisons between mean initial and final systolic blood pressure levels (SBP) in women (p = 0.007; Cohen's d = 0.50), pre- and post-training heart rate (p = 0.02; Cohen's d = 0.60) and anxiety levels (p = 0.01; Cohen's d = 1.04) were significant. Comparisons between pre- and post-training SBP (p = 0.006; Cohen's d = 0.81) and pre- and post-training anxiety levels (p = 0.04; Cohen's d = 0.32) were significant among males. In conclusion, paced breathing training with biofeedback therapy can be promising to reduce anxiety levels in individuals with essential arterial hypertension.
Revisão dos novos modelos de produção: Economia Circular, Bioeconomia e Biossociedade
Authors: Maia Vitória dos Santos Fontanezi , Shibata Antônio Emílio , Romão Ediene Monteiro 
Published: August 2021

O aumento populacional e a forma convencional de produção linear fazem com que seja necessário analisar conceitos referentes a economia circular, bioeconomia e biossociedade, teorias já existentes e que já são aplicáveis em muitos setores da sociedade. Nesse sentido, a preocupação com a qualidade de vida e do meio ambiente são precursores para o desenvolvimento de uma sociedade com um maior engajamento de novos modos de produção, mais limpos e otimizados. Diante disso, o presente artigo traz uma revisão bibliográfica sobre os novos modelos de produção, envolvendo a economia circular, a bioeconomia e a biossociedade. Tem como objetivo introduzir o conceito como uma alternativa tecnológica sustentável, que torna os processos mais limpos e econômicos, como a otimização de processos e aproveitamento de biomassa e outros resíduos. A pesquisa foi desenvolvida ao se construir uma revisão a respeito do tema, passando, então, por uma abordagem geral, apresentando a origem, aplicabilidade e características tecnológicas sobre a temática. Conclui-se, com ênfase, a importância de se estudar novos modelos de produção para promover e melhorar a capacidade de produção mais limpa e sustentável, além de potencializar a divulgação desses conceitos em meio a pesquisas.
DETERMINAN TINGKAT PENGETAHUAN IBU MENYUSUI TENTANG PEMBERIAN ASI EKSKLUSIF PADA BAYI 0-6 BULAN DI PUSKESMAS SUNGAI KAKAP TAHUN 2019
Authors: Melyani Katarina Iit, 
Published: August 2021

DETERMINAN TINGKAT PENGETAHUAN IBU MENYUSUI TENTANG PEMBERIAN ASI EKSKLUSIF PADA BAYI 0-6 BULAN DI PUSKESMAS SUNGAI KAKAP TAHUN 2019
1Katarina Iit, 2Melyani
Akademi Kebidanan Panca Bhakti Pontianak
Email Korespendensi: katarinaiit17@gmail.com
Abstrak
Pada tahun 2017 persentase bayi baru lahir yang mendapatkan ASI eksklusif sebesar 61,33%. Angka tersebut sudah melampaui target renstra tahun 2017 yaitu 44%. Persentase tertinggi cakupan pemberian ASI terdapat pada Nusa Tenggara Barat (87, 35%), sedangkan persentase terendah terdapat pada papua (15,32%). Adapun ASI eksklusif adalah pemberian ASI saja pada bayi selama 0-6 bulan tanpa tambahan makanan dan minuman lain seperti susu formula, jeruk, madu, air teh. ASI dapat menurunkan angka kematian bayi karena meningkatkan daya imunitasnya sehingga lebih tahan terhadap penyakit. Hasil studi pendahuluan di Puskesmas Sungai Kakap ditemukan 32 ibu yang memberikan ASI eksklusif pada bayi 0-6 bulan.Tujuan penelitian adalah untuk mengetahui DeterminanTingkat Pengetahuan Ibu Tentang Pemberian ASI Secara Eksklusif Pada Bayi 0-6 bulan Di Puskesmas Sungai Kakap PadaTahun 2019.Desain penelitian ini menggunakan deskriptif dengan pendekatan cross sectionalPopulasi yaitu ibu yang menyusui bayi usia 0-6 bulan di wilayah kerja puskesmas sungai kakap sebanyak 107 responden. Instrumen yang digunakan dalam penelitian ini adalah kuesioner. Analisis yang digunakan dalam penelitian ini adalah analisis univariate dan Bivariate.Teknik sampel dalam penelitian ini menggunakan purposivesampling.Hasil Penelitian menjelaskan bahwa ada hubungan antara usia dengan Pemberian ASI Eksklusif dengan P value = 0,027, ada hubungan antara paritas dengan pemberian ASI Eksklusif dengan P value = 0,016, ada hubungan antara Pendidikan dengan pemberian ASI Eksklusif dengan P value = 0,022, ada hubungan yang bermakna antara Pengetahuan dengan pemberian ASI Eksklusif dengan P value = 0,040, ada hubungan yang bermakna antara Pekerjaan dengan pemberian ASI Eksklusif dengan P value= 0,010, ada hubungan yang bermakna antara dukungan suami dengan pemberian ASI Eksklusif dengan P value = 0,002.Kesimpulan dari penelitian dapat disimpulkan bahwa Determinan tingkat pengetahuan ibu menyusui di wilayah kerja Puskesmas Sungai Kakap termasuk kategori sedikit dari responden.Kata kunci: Pengetahuan, Ibu Menyusui, ASI Ekslusif
Case Report: A Novel Variant c.2262+3A>T of the SCN5A Gene Results in Intron Retention Associated With Incessant Ventricular Tachycardias
Authors: Yin Jie , Zhou Jia , Chen Jinlong , Xu Ting , Zhang Zhongman , Zhang Han , Yuan Chang , Cheng Xueying , Qin Yuming , Zheng Bixia , Wang Chunli , Yang Shiwei , Jia Zhanjun 
Published: August 2021

Objective: Voltage-gated sodium channel Nav1.5 encoded by the SCN5A gene plays crucial roles in cardiac electrophysiology. Previous genetic studies have shown that mutations in SCN5A are associated with multiple inherited cardiac arrhythmias. Here, we investigated the molecular defect in a Chinese boy with clinical manifestations of arrhythmias.Methods: Gene variations were screened using whole-exome sequencing and validated by direct Sanger sequencing. A minigene assay and reverse transcription PCR (RT-PCR) were performed to confirm the effects of splice variants in vitro. Western blot analysis was carried out to determine whether the c.2262+3A&gt;T variant produced a truncated protein.Results: By genetic analysis, we identified a novel splice variant c.2262+3A&gt;T in SCN5A gene in a Chinese boy with incessant ventricular tachycardias (VT). This variant was predicted to activate a new cryptic splice donor site and was identified by in silico analysis. The variant retained 79 bp at the 5′ end of intron 14 in the mature mRNA. Furthermore, the mutant transcript that created a premature stop codon at 818 amino acids [p.(R818*)] could be produced as a truncated protein.Conclusion: We verified the pathogenic effect of splicing variant c.2262+3A&gt;T, which disturbed the normal mRNA splicing and caused a truncated protein, suggesting that splice variants play an important role in the molecular basis of early onset incessant ventricular tachycardias, and careful molecular profiling of these patients will be essential for future effective personalized treatment options.
Patient Reported Experiences and Delays During the Diagnostic Pathway for Pulmonary Fibrosis: A Multinational European Survey
Authors: van der Sar Iris G. , Jones Steve , Clarke Deborah L. , Bonella Francesco , Fourrier Jean Michel , Lewandowska Katarzyna , Bermudo Guadalupe , Simidchiev Alexander , Strambu Irina R. , Wijsenbeek Marlies S. , Parfrey Helen 
Published: August 2021

Introduction: Pulmonary fibrosis includes a spectrum of diseases and is incurable. There is a variation in disease course, but it is often progressive leading to increased breathlessness, impaired quality of life, and decreased life expectancy. Detection of pulmonary fibrosis is challenging, which contributes to considerable delays in diagnosis and treatment. More knowledge about the diagnostic journey from patients' perspective is needed to improve the diagnostic pathway. The aims of this study were to evaluate the time to diagnosis of pulmonary fibrosis, identify potential reasons for delays, and document patients emotions.Methods: Members of European patient organisations, with a self-reported diagnosis of pulmonary fibrosis, were invited to participate in an online survey. The survey assessed the diagnostic pathway retrospectively, focusing on four stages: (1) time from initial symptoms to first appointment in primary care; (2) time to hospital referral; (3) time to first hospital appointment; (4) time to final diagnosis. It comprised open-ended and closed questions focusing on time to diagnosis, factors contributing to delays, diagnostic tests, patient emotions, and information provision.Results: Two hundred and seventy three participants (214 idiopathic pulmonary fibrosis, 28 sarcoidosis, 31 other) from 13 countries responded. Forty percent of individuals took ≥1 year to receive a final diagnosis. Greatest delays were reported in stage 1, with only 50.2% making an appointment within 3 months. For stage 2, 73.3% reported a hospital referral within three primary care visits. However, 9.9% reported six or more visits. After referral, 76.9% of patients were assessed by a specialist within 3 months (stage 3) and 62.6% received a final diagnosis within 3 months of their first hospital visit (stage 4). Emotions during the journey were overall negative. A major need for more information and support during and after the diagnostic process was identified.Conclusion: The time to diagnose pulmonary fibrosis varies widely across Europe. Delays occur at each stage of the diagnostic pathway. Raising awareness about pulmonary fibrosis amongst the general population and healthcare workers is essential to shorten the time to diagnosis. Furthermore, there remains a need to provide patients with sufficient information and support at all stages of their diagnostic journey.
A Bulk Retrospective Study of Robot-Assisted Stereotactic Biopsies of Intracranial Lesions Guided by Videometric Tracker
Authors: Liu Huan-Guang , Liu Yu-Ye , Zhang Hua , Meng Fan-Gang , Zhang Kai , Zhu Guan-Yu , Chen Ying-Chuan , Liu De-Feng , Zhang Jian-Guo , Yang An-Chao 
Published: August 2021

Background: Biopsies play an important role in the diagnosis of intracranial lesions, and robot-assisted procedures are increasingly common in neurosurgery centers. This research investigates the diagnoses, complications, and technology yield of 700 robotic frameless intracranial stereotactic biopsies conducted with the Remebot system.Method: This research considered 700 robotic biopsies performed between 2016 and 2020 by surgeons from the Department of Functional Neurosurgery in Beijing's Tiantan Hospital. The data collected included histological diagnoses, postoperative complications, operation times, and the accuracy of robotic manipulation.Results: Among the 700 surgeries, the positive rate of the biopsies was 98.2%. The most common histological diagnoses were gliomas, which accounted for 62.7% of cases (439/700), followed by lymphoma and germinoma, which accounted for 18.7% (131/700) and 7.6% (53/700). Bleeding was found in 14 patients (2%) by post-operation computed tomography scans. A total of 29 (4.14%) patients had clinical impairments after the operation, and 9 (1.29%) experienced epilepsy during the operation. The post-biopsy mortality rate was 0.43%. Operation time—from marking the cranial point to suturing the skin—was 16.78 ± 3.31 min (range 12–26 min). The target error was 1.13 ± 0.30 mm, and the entry point error was 0.99 ± 0.24 mm.Conclusion: A robot-assisted frameless intracranial stereotactic biopsy guided by a videometric tracker is an efficient, safe, and accurate method for biopsies.
ANK3 Gene Polymorphism Rs10994336 Influences Executive Functions by Modulating Methylation in Patients With Bipolar Disorder
Authors: Tang Lili , Liu Juan , Zhu Yue , Duan Jia , Chen Yifan , Wei Yange , Gong Xiaohong , Wang Fei , Tang Yanqing 
Published: August 2021

Background: A large body of evidence suggests that epigenetic modification including DNA methylation plays a critical role in BD's pathogenesis while the identification of methylation quantitative trait loci (meQTLs) shed light on the interpretation of the function of genetic variants in non-coding regions. The intronic single nucleotide polymorphism (SNP) rs10994336 within the ANK3 has emerged as one of the most replicated risk variants for bipolar disorder (BD) in genome-wide association studies. Whether rs10994336 functions as a meQTL to mediate the association between genotype and phenotype remains unclear.Method: A total of 154 patients with BD and 181 healthy controls (HC) were recruited. The genotypes of rs10994336 and methylation levels of CpG sites within ANK3 were tested. Executive functions were assessed using a computerized version of the Wisconsin Card Sorting Test (WCST).Results: Bipolar disorder patients with the risk-T allele of rs10994336 scored lower on tests of executive function compared to homozygous CC carriers, after controlling for age, gender, and education level. No significant difference was found in HC individuals. The risk-T allele is associated with a lower methylation level of CpG site cg02172182 in HC after multiple corrections and replicated in the BD group in the same direction. Further mediation analysis revealed that the cg02172182 methylation significantly mediated the association between the polymorphism rs10994336 and PE index of WCST in patients with BD.Conclusion: Our study suggests that BD-related genetic variant rs10994336 in ANK3 impacts executive functions by modulating ANK3 methylation, supporting the theory that methylation acts as a mediator between genotype and phenotype.
Wrist, but Not Back, Isometric Contraction Induced Widespread Hypoalgesia in Healthy Participants
Authors: Mailloux Catherine , Wideman Timothy H. , Massé-Alarie Hugo 
Published: August 2021

Objective: Exercise may reduce pain sensitivity. This phenomenon called exercise-induced hypoalgesia is observed in different types of exercises and involves the activation of endogenous pain modulation systems. Although the effect of limb exercise on pain sensitivity has often been tested, few studies explored the impact of back exercises that are often used to treat low back pain. The main objective is to measure the effect of back-muscle exercise on pain sensitivity and compare it to the effect of a limb-muscle exercise.Methods: Twenty-three participants who were pain-free performed a 4-min wrist flexion isometric contraction followed by a 4-min low back extension, separated by a 20-min break. Pressure pain thresholds were tested at two low back (S1 spinous process, lumbar erector spinae muscle) and two wrist (capitate bone, wrist flexor muscles) sites before and after each exercise. For each exercise, sites were considered as remote or local in relation to the muscles contracted during the exercise. An independent sample of 11 participants was recruited to confirm the influence of low back extension on pain sensitivity.Results: Wrist exercise induced a larger increase in pain sensitivity than back exercise at the remote site. Only wrist exercise induced a hypoalgesia effect at both the local and the remote sites. Back exercise induced a similar effect in the independent sample.Conclusions: This study showed that back and wrist exercises induced a distinct effect on pain sensitivity in participants who were pain-free. The wrist exercise induced a systemic reduction in pain sensitivity (locally and remotely), whereas the back exercise did not. This differential effect may be present because wrist exercise induced most fatigue compared with the back exercise.
Epidemiology of Bleeding in Critically Ill Children
Authors: Sequeira Jake , Nellis Marianne E. , Karam Oliver 
Published: August 2021

Objective: Bleeding can be a severe complication of critical illness, but its true epidemiologic impact on children has seldom been studied. Our objective is to describe the epidemiology of bleeding in critically ill children, using a validated clinical tool, as well as the hemostatic interventions and clinical outcomes associated with bleeding.Design: Prospective observational cohort study.Setting: Tertiary pediatric critical care unitPatients: All consecutive patients (1 month to 18 years of age) admitted to a tertiary pediatric critical care unitMeasurements and Main Results: Bleeding events were categorized as minimal, moderate, severe, or fatal, according to the Bleeding Assessment Scale in Critically Ill Children. We collected demographics and severity at admission, as evaluated by the Pediatric Index of Mortality. We used regression models to compare the severity of bleeding with outcomes adjusting for age, surgery, and severity. Over 12 months, 902 critically ill patients were enrolled. The median age was 64 months (IQR 17; 159), the median admission predicted risk of mortality was 0.5% (IQR 0.2; 1.4), and 24% were post-surgical. Eighteen percent of patients experienced at least one bleeding event. The highest severity of bleeding was minimal for 7.9% of patients, moderate for 5.8%, severe for 3.8%, and fatal for 0.1%. Adjusting for age, severity at admission, medical diagnosis, type of surgery, and duration of surgery, bleeding severity was independently associated with fewer ventilator-free days (p &lt; 0.001) and fewer PICU-free days (p &lt; 0.001). Adjusting for the same variables, bleeding severity was independently associated with an increased risk of mortality (adjusted odds ratio for each bleeding category 2.4, 95% CI 1.5; 3.7, p &lt; 0.001).Conclusion: Our data indicate bleeding occurs in nearly one-fifth of all critically ill children, and that higher severity of bleeding was independently associated with worse clinical outcome. Further multicenter studies are required to better understand the impact of bleeding in critically ill children.
Anatomical Study of the Hepatic Veins in Segment 4 of the Liver Using Three-Dimensional Visualization
Authors: Zhang Jun , Guo Xiaochao , Qiao Qilu , Zhao Jianxun , Wang Xin 
Published: August 2021

Objective: The current study aimed to examine the anatomical structure of the hepatic vein of segment IV liver (S4) of the liver using three-dimensional (3D) visualization technology in order to explore the surgical value of the middle hepatic vein (MHV) manipulation and highlight the importance of current research in hepatic surgery.Methods: Between January 2014 and December 2019, 52 patients with abdominal diseases(not including hepatic disease) were selected for multiphasic computed tomography-enhanced scans of the upper abdomen. A 3D visualization system was utilized to display the structural details of the hepatic veins in S4 of their livers. Couinaud's eight-segment classification system was used to denote the liver' sections.Results: The constructed 3D model clearly displayed vascular morphological characteristics and their location in the liver, hepatic artery and vein system, and portal vein system. Of the 52 patients, 43 had an umbilical fissure vein (UFV) (82.7%), 19 had an accessory S4 liver vein (36.5%), 16 had both a UFV (30.8%) and an accessory S4 liver vein, and 6 had neither (11.5%). A total of 79% of the patients with a UFV and 74.2% of those with an accessory S4 liver vein had venous blood returning into the left hepatic vein.Conclusion: 3D visualization technology was used to determine hepatic venous return of S4 hepatic veins and was found to improve the safety of evaluation in hepatic surgery.