bluuebunny/crossref_metadata_2025_split huggingface dataset:
0D/1D Heterojunction Implant with Electro‐Mechanobiological Coupling Cues Promotes Osteogenesis
Authors: Huang Xiao , Xing Jun , Wang Zhengao , Han Jin , Wang Renxian , Li Changhao , Xiao Cairong , Lu Fang , Zhai Jinxia , Zhou Zhengnan , Li Yangfan , Zhou Lei , Song Zhiguo , Chen Dafu , Yu Peng , Ning Chengyun , Jiang Xieyuan 
Published: September 2021

AbstractMimicking the natural bone extracellular matrix containing intrinsic topography and electrical signals is an effective way to modulate bone regeneration. However, simultaneously coupling of the intrinsic mechanobiology and electrical cues of implant to modulate bone regeneration remains ignored. Here, the authors report in situ designation of titanium dioxide (TiO2) nanocone/bismuth oxide (Bi2O3) nanodot heterojunctions on bone implant surface to electro‐biomechanically trigger osseointegration at bone/implant interface. TiO2 nanocone/Bi2O3 nanodot heterojunctions exhibit built‐in electric field at the nanoscale interface and elastic modulus equivalent to that of bone tissue. The nano‐heterojunctions significantly promoted the attachment, spreading, and osteogenic differentiation of bone marrow mesenchymal stem cells in vitro, and the osteogenesis in vivo. The authors also show that the effects of nano‐heterojunctions on osteogenesis are mediated by yes‐associated protein biomechanical signal pathway and intracellular enrichment induced Phosphatidylinositol 3‐kinase signal pathway. Their findings highlight the coupling of topographical and electric parameters of biomaterials for modulating cell behaviors.
Pro‐Healing Zwitterionic Skin Sensor Enables Multi‐Indicator Distinction and Continuous Real‐Time Monitoring
Authors: Guo Hongshuang , Bai Ming , Zhu Yingnan , Liu Xinmeng , Tian Shu , Long You , Ma Yiming , Wen Chiyu , Li Qingsi , Yang Jing , Zhang Lei 
Published: September 2021

AbstractIn both artificial electronic and ionic skins, the distinction of multi‐stimuli response in a single sensing unit is challenging, due to unavoidable mutual signal interference. Here, a zwitterionic skin sensor system that can continuously monitor and differentiate three‐stimuli‐responsive information in real‐time is designed. This sandwich‐structured sensor system is based on a zwitterionic thermo–glucose‐sensitive skin‐like hydrogel at its upper and lower layers with a middle isolation elastomer layer, enabling monitoring and distinction of temperature, mechanical and glucose information without signal interference: 1) the capacitance of the upper/lower layers as glucose–temperature‐insensitive is variable to measure strain; 2) the resistance of the upper hydrogel as glucose‐insensitive is variable to measure strain and temperature; and 3) the resistance of the lower hydrogel can detect three indicators. Based on the skin sensor system, a smart wound dressing is developed to pro‐heal chronic diabetic wounds and enable continuous real‐time monitoring of three indicators—infection, swelling, and blood glucose. This work provides a new method of real‐time monitoring and the distinction of multi‐stimuli response in a wearable device.
A Textile‐Based Temperature‐Tolerant Stretchable Supercapacitor for Wearable Electronics
Authors: Lee Hanchan , Jung Gyusung , Keum Kayeon , Kim Jung Wook , Jeong Hyein , Lee Yong Hui , Kim Dong Sik , Ha Jeong Sook 
Published: September 2021

AbstractAmong the extensive development of wearable electronics, which can be implanted onto bodies or embedded in clothes, textile‐based devices have gained significant attention. For daily basis applications, wearable energy storage devices are required to be stable under harsh environmental conditions and different deformational conditions. In this study, a textile‐based stretchable supercapacitor with high electrochemical performance, mechanical stability, and temperature tolerance over a wide temperature range is reported. It exhibits high areal capacitances of 28.0, 30.4, and 30.6 mF cm−2 at −30, 25, and 80 °C, respectively, while the capacitance remains stable over three repeated cycles of cooling and heating from −30 to 80 °C. The supercapacitor is stable under stretching up to 50% and 1000 repetitive cycles of stretching. A temperature sensor and an liquid‐crystal display are simultaneously driven at temperatures between −20 and 80 °C by the supercapacitors. The supercapacitors are woven into a nylon glove power a micro‐light‐emitting diode stably regardless of the bending of the index finger. Furthermore, the encapsulated supercapacitors retain the capacitance during being immersed in water for a few days. This study demonstrates the potential application of the fabricated supercapacitor as a wearable energy storage device that works under extreme temperature variations, high humidity, and body movements.
Multistage Responsive Materials for Real‐time, Reversible, and Sustainable Light‐Writing
Authors: Liu Jize , Guo Quanquan , Zhang Xinxing , Gai Jinggang , Zhang Chuhong 
Published: September 2021

AbstractStimulus‐responsive materials with designable integrated functions bridge the intelligent systems in future lifestyles with the Internet of Things (IoT). The growing trend for IoT and corresponding advanced devices will involve a great number of electronic disposables, which may place heavy burdens on the environment. Here, an elaborately designed multistage responsive material is reported for real‐time, reversible light‐writing based on organized stage‐by‐stage responsive behaviors and polarity‐dependent physicochemical fluorescence response, where the stimulus is accurately delivered through a completely reversible “light‐heat‐fluorescence” pathway. The resulted materials can be pollution‐freely written by hand‐controlled near‐infrared laser within 5 s, spontaneously erased within 20 s, and exhibit excellent re‐writing ability (more than 5000 times while the variance of chromaticity coordinates <0.0008), which is difficult to achieve by traditional laser writing technologies. This study is a step toward high‐performance long‐life functional devices based on reversible multistage responsive materials for future IoT lifestyles.
Noble‐Metal‐Assisted Fast Interfacial Oxygen Migration with Topotactic Phase Transition in Perovskite Oxides
Authors: Wang Qian , Gu Youdi , Zhu Wenxuan , Han Lei , Pan Feng , Song Cheng 
Published: September 2021

AbstractTransition‐metal perovskite oxides constitute a series of functional material systems for electronics, catalysis, and energy‐conversion processes, in which oxygen migration and evolution play a key role. However, the stable metal–oxygen (MO) bond forms a large energy barrier inhibiting ion diffusion. Therefore, seeking efficient and facile approaches to accelerate oxygen kinetics has become a significant issue. Here, the interaction (interfacial charge transfer and cooperative bonding) between noble metal (Pt, Ag) and perovskites oxide (SrCoO3−δ) is employed to weaken the (MO) bond and decrease the energy barrier of oxygen migration. Noble metal layers serving as oxygen pumps can continuously extract oxygen from oxide films to the atmosphere. The temperature of the topotactic phase transition from perovskite (SrCoO3) to brownmillerite (SrCoO2.5) is remarkably lowered from ≈200 °C to room temperature. Furthermore, this approach can also be applied to SrFeO3 for similar topotactic phase reduction by moderate thermal activation. The finding of this study paves a promising and general pathway to achieve fast oxygen migration in perovskite oxides, with important application prospects in low‐temperature electrodes and high‐activity catalysis interface.
DLP 4D‐Printing of Remotely, Modularly, and Selectively Controllable Shape Memory Polymer Nanocomposites Embedding Carbon Nanotubes
Authors: Cortés Alejandro , Cosola Andrea , Sangermano Marco , Campo Mónica , González Prolongo Silvia , Pirri Candido Fabrizio , Jiménez‐Suárez Alberto , Chiappone Annalisa 
Published: September 2021

AbstractAn in‐depth investigation on novel electro‐activated shape memory polymer composites (SMPCs) for digital light processing 3D‐Printing, consisting of a poly(ethylene glycol) diacrylate/poly(hydroxyethyl methacrylate) matrix embedding multi‐walled carbon nanotubes (CNTs), is reported here. The composition of the photocurable (meth)acrylate system is finely tuned to tailor the thermomechanical properties of the matrix, whereas the effect of CNTs on the photoreactivity and rheological properties of the formulations is investigated to assess the printability. Electrical measurements confirmed that the incorporation of CNT into the polymeric matrix enables the electrical conductivity and thus the possibility to remotely heat the nanocomposite using the Joule effect. The feasibility to drive a shape memory cycle via Joule heating is proved, given that the high shape fixity (Rf) and shape recovery (Rr) ratios achieved (Rf ≈ 100%,Rr > 95%) confirmed the significant electrically‐triggered responsiveness of such CNT/SMPCs. Finally, it is shown how to activate a modular and selective electro‐activated shape recovery, which may ultimately envisage the 4D‐Printing of remotely and selectively controllable smart devices.
CRISPR/Cas9‐2D Silicene Gene‐Editing Nanosystem for Remote NIR‐II‐Induced Tumor Microenvironment Reprogramming and Augmented Photonic Tumor Ablation
Authors: Yin Haohao , Zhou Bangguo , Dong Caihong , Zhang Yan , Yu Jifeng , Pu Yinying , Feng Wei , Sun Liping , Hu Hui , Chen Yu , Xu Huixiong 
Published: September 2021

AbstractPhotothermal therapy (PTT) is a minimally invasive and highly specific antineoplastic treatment, whereas the significant upregulation of TXNDC5 gene expression following PTT cripples the photothermal ablation efficacy through protein processing in the endoplasmic reticulum signaling pathway, as transcriptome sequencing and bioinformatics analysis revealed in this research. To tackle this crucial issue, a second near‐infrared biowindow (NIR‐II) light‐controlled CRISPR/Cas9 nanosystem (silicene‐Cas9) is constructed based on biosafe and biodegradable 2D silicene nanosheets with desirable photothermal‐conversion capability. The elaborate system enables remote NIR‐II‐induced reprogramming of tumor microenvironment for enhanced photonic tumor ablation. Moreover, this CRISPR/Cas9 delivery system is carried out to precisely and efficiently knock down TXNDC5 for reprogramming the tumor microenvironment and amplifying the photothermal performance of silicene, exhibiting high efficiency and controlled gene‐editing capacity of 47.68% and significantly improving therapeutic effect of tumor ablation without recurrence both in vitro and in vivo. This work not only provides a paradigm of improving the effectiveness of photothermal tumor therapy, but also develops a safe and efficient 2D silicene‐based nonviral vector for harnessing CRISPSR/Cas9 technology‐mediated genome editing, which further broadens the biomedical application of 2D silicene nanosheets.
Wide Working Temperature Range Rechargeable Lithium–Sulfur Batteries: A Critical Review
Authors: Zhou Zhenfang , Li Guicun , Zhang Jiujun , Zhao Yufeng 
Published: September 2021

AbstractAt the technological forefront of energy storage, there is still a continuous upsurge in demand for high energy and power density batteries that can operate at a wide range of temperature. Rechargeable lithium sulfur batteries stand out among other advanced cell concepts owing to their ultrahigh theoretical gravimetric energy density characteristic as well as merits of low cost and environmental friendliness. Although achieving good operability of ambient lithium sulfur batteries, extending their workability to both higher and lower temperatures is also of paramount importance especially for future task‐specific applications. As a first attempt, this review presents a comprehensive understanding on the advances, challenges, and future research directions on lithium sulfur batteries operating at both low and high temperature extremes. From a material perspective, the workability of sulfur‐containing cathode materials, advanced electrolytes (from conventional liquid to quasi‐ and all‐solid‐state electrolytes), lithium metal anodes and the electrochemically inert components (separators and interlayer materials) at extreme temperatures are thoroughly analyzed. The insurmountable challenges and mechanistic understandings caused by thermal changes are critically reviewed. Finally, potential future research directions and prospects for lithium sulfur batteries operated at a wide range of temperature are also proposed.
3D Wearable Fabric‐Based Micro‐Supercapacitors with Ultra‐High Areal Capacitance
Authors: Li Dongdong , Yang Sheng , Chen Xin , Lai Wen‐Yong , Huang Wei 
Published: September 2021

AbstractMiniaturized electronics require integrated unit configuration in very limited space, where energy storage per unit area is thus extremely critical. Micro‐supercapacitors (MSCs), mainly established on planar substrates, are superior but still suffer from limited areal capacitance. Herein, a novel strategy is introduced to construct high cross‐section MSCs using 3D fabrics as the porous skeleton. Interdigitated poly(3,4‐ethylenedioxythiophene): poly(styrenesulfonate) (PEDOT:PSS) is patterned on 3D fabrics to achieve continuous conductive networks, while MnO2 microspheres epitaxially grown on PEDOT:PSS are fully exposed to electrolyte with the support of fabric fibers. The unique architecture can utilize more active sites of thick electrodes and the high conductivity of interpenetrating fiber networks. The resulting fabric‐based MSCs demonstrate ultra‐high areal capacitance of 135.4 mF cm−2, which is 3.5 times that of devices on polyethylene terephthalate substrates and is among the highest values for planar‐based MSCs using the same interdigital geometry. Moreover, the flexible fabrics endow MSCs with extremely high bending stability with 94% capacitance retention even after 3000 cycles. These figures‐of‐merit enable fabric‐based MSCs promising to be used in the next‐generation of wearable electronics.
Immune Cycle‐Based Strategies for Cancer Immunotherapy
Authors: Li Yanhua , Liu Xiaohan , Zhang Xia , Pan Wei , Li Na , Tang Bo 
Published: September 2021

AbstractThe immune system is composed of immune organs, immune cells, and immunoactive substances, which plays a vital role in antitumor immunity in cancer immunotherapy. During the process of the antitumor immune response, many factors are involved in the cancer immune cycle. Therefore, developing intelligent strategies based on the steps of the cancer immune cycle to elicit the immune responses for enhanced cancer immunotherapy is of great significance. In this review, the key factors in each step of the cancer immune cycle are discussed, and then, the intelligent therapeutic strategies for modulating the immune surveillance against cancer are highlighted. Considering the demand for cancer immunotherapy in clinic, some suggestions for constructing new intelligent strategies are also put forward, which will make antitumor immunity more effective and advance the development of cancer immunotherapy.
Substrate‐Independent and Re‐Writable Surface Patterning by Combining Polydopamine Coatings, Silanization, and Thiol‐Ene Reaction
Authors: Li Shuai , Scheiger Johannes M. , Wang Zhenwu , Dong Zheqin , Welle Alexander , Trouillet Vanessa , Levkin Pavel A. 
Published: September 2021

AbstractPolydopamine coating is a unique, simple, and substrate‐independent surface functionalization strategy. Techniques for secondary functionalization, patterning, and re‐functionalization of polydopamine modified materials are important to broaden the scope of applications of such materials in a variety of fields. Here, a facile and substrate‐independent strategy for surface functionalization and patterning is presented. This approach combines the advantages of three important methods: facile and substrate‐independent polydopamine coating, versatile gas phase silanization, and rapid thiol‐ene photoclick reaction for patterning. They demonstrate equally efficient functionalization and patterning of diverse materials, such as glass, polytetrafluoroethylene, aluminum, polypropylene, or polyethylene. They also show the possibility of controlled chemical removal of the patterns or surface functionalization by treatment with tetrabutylammonium fluoride, which allows re‐modification or re‐patterning of the substrate. Thus, this universal and powerful approach for substrate independent surface modification and patterning can significantly facilitate the development of novel functional materials and devices useful for various applications.
Superior Rate Mesoporous Carbon Sphere Array Composite via Intercalation and Conversion Coupling Mechanisms for Potassium‐Ion Capacitors
Authors: Liu Hongxin , Zhang Wulin , Song Yan , Li Lanlan , Zhang Chengwei , Wang Gongkai 
Published: September 2021

AbstractCarbonaceous materials have been usually adopted as the anode for high energy density potassium‐ion hybrid capacitors (KICs) owing to their low voltage plateau, high conductivity, and excellent electrochemical compatibility. The improvements of their specific capacity and sluggish intercalation mechanism are still challenges to further boost the energy density of KICs while maintaining high power density and long cycle life. Herein, a N‐doped mesoporous carbon sphere array composite is developed by a dual‐templates method. The N‐doped carbon sphere array with interpenetrated macro‐ and meso‐pores facilitates the fast electron transport and rapid K+ diffusion. The uniformly introduced Co3O4 nanoparticles (NPs) confined in the array enable a kinetically boosted conversion reaction for excess and fast K+ storage. The partially oxidized Co NPs can efficiently enhance the conductivity of the entire composite. By introducing this optimized conversion capacity from encapsulated Co3O4 NPs, the composite with intercalation and conversion coupling mechanisms displays superior capacity and cycle life. The assembled KICs exhibit high energy/power densities (148 Wh kg−1/124 W kg−1) and great cycling performance (94% after 5000 cycles, 0.5 A g−1). This promising strategy demonstrates an example for carbonaceous composite anode with synergistic K+ storage hybrid mechanism toward high performance KICs.
The Importance of Interfaces in Multi‐Material Biofabricated Tissue Structures
Authors: Viola Martina , Piluso Susanna , Groll Jürgen , Vermonden Tina , Malda Jos , Castilho Miguel 
Published: September 2021

AbstractBiofabrication exploits additive manufacturing techniques for creating 3D structures with a precise geometry that aim to mimic a physiological cellular environment and to develop the growth of native tissues. The most recent approaches of 3D biofabrication integrate multiple technologies into a single biofabrication platform combining different materials within different length scales to achieve improved construct functionality. However, the importance of interfaces between the different material phases, has not been adequately explored. This is known to determine material's interaction and ultimately mechanical and biological performance of biofabricated parts. In this review, this gap is bridged by critically examining the interface between different material phases in (bio)fabricated structures, with a particular focus on how interfacial interactions can compromise or define the mechanical (and biological) properties of the engineered structures. It is believed that the importance of interfacial properties between the different constituents of a composite material, deserves particular attention in its role in modulating the final characteristics of 3D tissue‐like structures.
Tattoo Inks for Optical Biosensing in Interstitial Fluid
Authors: Pazos Martalu D. , Hu Yubing , Elani Yuval , Browning Kathryn L. , Jiang Nan , Yetisen Ali K. 
Published: September 2021

AbstractThe persistence of traditional tattoo inks presents an advantage for continuous and long‐term health monitoring in point of care devices. The replacement of tattoo pigments with optical biosensors aims a promising alternative for monitoring blood biomarkers. Tattoo inks functionalization enables the control of interstitial biomarkers with correlated concentrations in plasma, to diagnose diseases, evaluate progression, and prevent complications associated with physio pathological disorders or medication mismatches. The specific biomarkers in interstitial fluid provide a new source of information, especially for skin diseases. The study of tattoo inks displays insufficient regulation in their composition, a lack of reports of the related complications, and a need for further studies on their degradation kinetics. This review focuses on tattoo optical biosensors for monitoring dermal interstitial biomarkers and discusses the clinical advantages and main challenges for in vivo implantation. Tattoo functionalization provides a minimally invasive, reversible, biocompatible, real‐time sensing with long‐term permanence and multiplexing capabilities for the control, diagnosis, and prevention of illness; it enables self‐controlling management by the patient, but also the possibility of sending the records to the doctor.
Stem/Proliferative and Differentiated Cells within Primary Murine Colonic Epithelium Display Distinct Intracellular Free Ca2+ Signal Codes
Authors: Mestril Sebastian , Kim Raehyun , Hinman Samuel S. , Gomez Shawn M. , Allbritton Nancy L. 
Published: September 2021

AbstractThe second messenger, intracellular free calcium (Ca2+), acts to transduce mitogenic and differentiation signals incoming to the colonic epithelium. A self‐renewing monolayer of primary murine colonic epithelial cells is formed over a soft, transparent hydrogel matrix for the scalable analysis of intracellular Ca2+ transients. Cultures that are enriched for stem/proliferative cells exhibit repetitive, high frequency (≈25 peaks h−1), and short pulse width (≈25 s) Ca2+ transients. Upon cell differentiation the transient frequency declines by 50% and pulse width widens by 200%. Metabolites and growth factors that are known to modulate stem cell proliferation and differentiation through Wnt and Notch signaling pathways, including CHIR‐99021, N‐[(3,5‐Difluorophenyl)acetyl]‐L‐alanyl‐2‐phenylglycine‐1,1‐dimethylethyl ester (DAPT), bone morphogenetic proteins (BMPs), and butyrate, also modulate Ca2+ oscillation patterns in a consistent manner. Increasing the stiffness of the supportive matrix from 200 Pa to 3 GPa shifts Ca2+ transient patterns toward those resembling differentiated cells. The ability to monitor Ca2+ oscillations with the spatial and temporal resolution offered by this platform, combined with its amenability to high‐content screens, provides a powerful tool for investigating real‐time communication within a wide range of primary tissues in addition to the colonic epithelium.