bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Sales (penjualan) dan Debt to Equity Ratio (DER) Terhadap Pertumbuhan Laba
Authors: Sulbahri Rifani Akbar 
Published: September 2021

The company always wants its business to grow. These developments will occur if supported by the ability of management to establish policies in planning, obtaining, and utilizing funds to maximize corporate values. It cannot be denied that profit growth cannot be separated from the company's financial performance. One of the most commonly used financial analysis tools is financial ratios. This research was conducted to reexamine the relationship of Sales and financial ratios with profit growth. The inconsistency of the results from previous studies caused this issue to be interesting to be examined again. This study aims to provide evidence that the variable Sales (Sales) and Debt to Equity Ratio, affect the profit growth. The conclusion in this study obtained Sales significant effect on earnings changes with the value of prob. sales variable <critical probability value (α = 5%) of 0.0043 <0.05, so that the sales variable has a significant effect on earnings changes.DER has a significant effect on earnings changes on prob. DER variable <critical probability value (α = 5%) of 0.0000 <0.05, so that the DER variable has a significant effect on earnings changes.

Abstrak
Perusahaan senantiasa menginginkan usahanya berkembang. Perkembangan tersebut akan terjadi apabila didukung oleh adanya kemampuan manajemen dalam menetapkan kebijaksanaan dalam merencanakan, mendapatkan, dan memanfaatkan dana-dana untuk memaksimumkan nilai-nilai perusahaan. Tidak dapat dipungkiri bahwa pertumbuhan laba tidak bisa terlepas dari kinerja keuangan perusahaan. Salah satu alat analisis keuangan yang paling sering digunakan adalah rasio keuangan. Penelitian ini dilakukan untuk menguji kembali hubungan Sales (Penjualan) dan rasio keuangan dengan pertumbuhan laba.Adanya ketidak konsistenan hasil dari penelitian-penelitian sebelumnya menyebabkan isu ini menarik untuk diteliti kembali. Penelitian ini bertujuan untuk memberikan bukti bahwa variabel Sales (Penjualan) dan Debt to Equity Ratio,berpengaruh terhadap pertumbuhan laba. Kesimpulan pada penelitian ini didapat Sales berpengaruh signifikan terhadap Perubahan laba dengan Nilai prob. variabel sales < nilai probabilitas kritis (α = 5%) sebesar 0.0043 < 0,05, sehingga variabel sales berpengaruh signifikan terhadap perubahan laba.DER berpengaruh signifikan terhadap Perubahan laba Nilai prob. variabel DER < nilai probabilitas kritis (α = 5%) sebesar 0.0000 < 0.05, sehingga variabel DER berpengaruh signifikan terhadap perubahan laba.
Kata Kunci : Pertumbuhan Laba, Penjualan, DER
Pengaruh Komitmen dan Kompensasi terhadap Kinerja Dosen pada Perguruan Tinggi Swasta (PTS)
Authors: Armanto Rully , Gunarto Muji 
Published: September 2021

This study aims to determine the effect of commitment and compensation on lecturer performance in private universities (PTS). The performance of lecturers in Indonesia, especially in PTS, is still considered unsatisfactory when compared to lecturers in state universities (PTN). The main factor that is suspected to be the cause is the commitment of the foundation as the owner and leader of the higher education institution as the manager and the compensation which is still low. The research sample was the permanent lecturers of the foundation at PTS in Palembang, totaling 44 respondents. The sampling technique used is cluster random sampling at Universities, Colleges, Academies, and Polytechnics. The statistical analysis technique used multiple regression analysis with the help of SPSS software. The results showed that commitment and compensation had a significant effect on the performance of lecturers at private universities in Palembang City. The most dominant factor in the performance of PTS lecturers in Palembang City is compensation, meaning that by increasing the compensation for lecturers, their performance will increase. The results of this study really provide input for the improvement of private universities in Palembang City because when viewed from the permanent income of private universities in Palembang City, it is still below the average decent income of a lecturer.

Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh komitmen dan kompensasi terhadap kinerja dosen pada Perguruan Tinggi Swasta (PTS). Kinerja dosen di Indonesia khususnya di PTS masih dirasa belum memuaskan jika dibandingkan dengan dosen di Perguruan Tinggi negeri (PTN). Faktor utama yang diduga menjadi penyebabnya adalah komitmen yayasan sebagai pemilik dan pimpinan perguruan tinggi sebagai pengelola serta kompensasi yang dirasa masih rendah. Sampel penelitian adalah dosen tetap yayasan pada PTS di Kota Palembang yang berjumlah 44 orang responden. Teknik sampling yang digunakan adalah cluster random sampling pada Universitas, Sekolah Tinggi, Akademi dan Politeknik. Teknik analisis statistik digunakan analisis regresi berganda dengan bantuan software SPSS. Hasil penelitian menunjukkan bahwa komitmen dan kompensasi berpengaruh signifikan terhadap kinerja dosen pada PTS di Kota Palembang. Faktor yang paling dominan terhadap kinerja dosen PTS di Kota Palembang adalah kompensasi, artinya bahwa dengan meningkatnya kompensasi bagi dosen, maka kinerjanya akan meningkat. Hasil penelitian ini sangat memberikan masukan bagi perbaikan PTS di Kota Palembang karena jika dilihat dari pendapatan dosen tetap pada PTS di Kota Palembang masih dibawah rata-rata pendapatan layak seorang dosen.
State of the art in dissociative electron attachment spectroscopy and its prospects
Authors: Pshenichnyuk S A , Asfandiarov N L , Vorob’ev A S , Matejčík Š 
Published: September 2021

Abstract
The latest achievements are presented in experimental and theoretical studies of resonance scattering of low-energy (0–15-eV) electrons from molecular targets in a gas phase resulting in the formation and decay of negative ions. The focus is on dissociative electron attachment spectroscopy for studying the microsecond dynamics of molecules containing an excess electron. Some studies of fundamental processes in isolated negative ions containing up to several electronvolts of excess energy are briefly described, and the possibility of using the results in interdisciplinary fields is discussed. A goal of the paper is to attract attention to the above-mentioned studies, which are rapidly developing abroad but only scarcely presented in the domestic literature.
LncRNA NEAT1 Promotes Gastric Cancer Progression Through miR-17-5p/TGFβR2 Axis Up-Regulated Angiogenesis
Authors: Xu Yangwei , Li Yanyan , Qiu Yue , Sun Fei , Zhu Guifang , Sun Jingbo , Cai Guixing , Lin Wanmei , Fu Yun , Wu Hongmei , Jiang Shanshan , Wen Zhihui , Feng Feiyan , Luo Junjie , Yang Yuqin , Zhang Qingling 
Published: September 2021

BackgroundLong non-coding RNAs (lncRNAs) have been indicated to play critical roles in gastric cancer (GC) tumorigenesis and progression. However, their roles in GC remain to be further elucidated.MethodsRT-qPCR and fluorescence in situ hybridzation (FISH) were conducted to detect the expression of lncRNA NEAT1 in GC tissues and cell lines. Gene Set Enrichment Analysis (GSEA) was performed to screen out potential phenotypes and pathways that NEAT1 may participate in. NEAT1-silenced AGS and MGC803 cells were constructed and a series of functional experiments to investigate the roles of NEAT1 in GC angiogenesis both in vitro and in vivo. RNA pull down and luciferase reporter assays were utilized to illustrate the mechanisms underlying the functions of NEAT1 in GC.ResultsWe observed that NEAT1 was upregulated in most GC specimens and cell lines. NEAT1 high was correlated with poor prognosis of GC patients. In vitro experiments showed that NEAT1 promoted GC angiogenesis by enhancing proliferation, migration, and tube formation ability of endothelial cells. Mechanism researches revealed that NEAT1 could competitively sponge miR-17-5p which targeted TGFβR2 directly. Subsequently, activate TGFβ/Smad pathway by following with upregulation of a series of classical proangiogenic factors especially VEGF.ConclusionThe study unveiled that the LncRNA NEAT1/miR-17-5p/TGFβR2 axis is a novel mechanism in GC angiogenesis. Disrupting this axis may be a potential strategy for GC treatment.
Reproductive History in Takotsubo Syndrome, A Register-Based Cohort Study
Authors: Tornvall Per , Pettersson Hans Järnbert 
Published: September 2021

Background: Takotsubo syndrome (TS) is a recently recognized serious heart condition that mainly affects women. Despite that 80–90% of the patients are women, few studies have focused on sex-specific characteristics such as female sex hormones and reproductive history. The aim of the study was to compare reproductive history in patients with TS with controls.Methods: This register-based cohort study compared reproductive history and off-spring birth characteristics between 158 TS patients without coronary artery stenoses and 236 age- and sex-matched controls (C) with coronary artery stenoses because of acute coronary syndrome (ACS-C), respectively, 285 without coronary artery stenoses with chest pain (CP-C).Results: There were no differences in pregnancy complications between TS and CP-C. Gestational length did not differ, but infants born to TS patients had lower birth weight for gestational age than CP-C with an odds ratio of 1.7 (95% confidence interval 1.2–2.5) for infants born small.Conclusion: The results showing an association between birth weight for gestational age and TS later in life are hypothesis-generating. The association is not likely causal and before delivery of small for gestational age infants can be considered as a risk marker for TS later in life the results need to be confirmed in independent studies
Surgical Interventions Are Effective for Treating Unruptured Sinus of Valsalva Aneurysms
Authors: Qiu Juntao , Xie Enzehua , Wang Yuetang , Wang Wei , Yu Cuntao , Luo Xinjin 
Published: September 2021

Background: This study investigates the optimal management for unruptured sinus of Valsalva aneurysms (USVAs) combined with other cardiovascular lesions.Methods: This retrospective study examined 33 USVA patients who underwent surgical repair from February 1, 2007 to January 31, 2012. We analyzed the surgical procedures and the patients' quality of life after surgery. Additionally, echocardiography follow-up was performed before and after the operation.Results: Most USVAs (87.8%) originated in the right coronary sinus. Aside from one patient who was preoperatively misdiagnosed as having a ruptured sinus of Valsalva aneurysm (SVA). USVAs of the right coronary sinus were addressed by reinforcing this sinus with a Dacron patch through the right ventricle. USVAs were corrected by aortotomy using an autogenous pericardium patch when they originated in the non-coronary or left coronary sinus. Thirty patients (90.9%) were followed up for 22–119 months. No early death, residual fistula or SVA recurrence were found during the follow-up period. They all had a good quality of life and good heart function (New York Heart Association class I–II).Conclusions: Active surgical repair of an USVA can be achieved with satisfactory results in patients combined with other cardiovascular lesions.
Association Between Proficiency and Efficiency in Electronic Health Records Among Pediatricians at a Major Academic Health System
Authors: Khairat Saif , Zalla Lauren , Gartland Allie , Seashore Carl 
Published: September 2021

Objective: The purpose of this study was to evaluate the variations in electronic health record (EHR) activity among General and Specialty pediatricians by investigating the time spent and documentation length, normalized for workload.Materials and Methods: We conducted a cross-sectional study of pediatric physicians using Epic EHR at a major Southeastern academic healthcare system. We collected user-level EHR activity data of 104 pediatric physicians over 91 days from April 1 to June 30, 2020.Results: Of the 104 pediatrics physicians, 56 (54%) were General pediatricians and 48 (46%) were Specialists pediatricians. General pediatricians spent an average of 17.6 min [interquartile range (IQR): 12.9–37] using the EHR per appointment, while Specialists spent 35.7 min (IQR: 28–48.4) per appointment.Significant negative associations were found between proficiency scores and the amount of time spent in the system for Generalists (p &lt; 0.001). On the contrary, significant positive associations were found between proficiency scores and the amount of time spent in the system for Specialists (p &lt; 0.01).Conclusions: We report an association between EHR proficiency and efficiency levels among pediatricians within the same healthcare system, receiving the same EHR training, and using the same EHR system. The profound differences in EHR activity suggest that higher priority should be given to redesigning EHR training methods to accommodate the learning needs of physicians.
Seismic Characteristics of Paleo-Pockmarks in the Great South Basin, New Zealand
Authors: Karaket Arunee , Chenrai Piyaphong , Huuse Mads 
Published: September 2021

Globally, a wide range of pockmarks have been identified onshore and offshore. These features can be used as indicators of fluid expulsion through unconsolidated sediments within sedimentary basin-fills. The Great South Basin, New Zealand, is one such basin where paleo-pockmarks are observed at around 1,500 m below the seabed. This study aims to describe the characteristics of paleo-pockmarks in the Great South Basin. Numerous paleo-pockmarks are identified and imaged using three-dimensional seismic reflection data and hosted by fine-grained sediments of the Middle Eocene Laing Formation. The paleo-pockmarks are aligned in a southwest to northeast direction to form a fan-shaped distribution with a high density of around 67 paleo-pockmarks per square kilometre in the centre of the study area. The paleo-pockmarks in this area have a similar shape, varying from sub-rounded to a rounded planform shape, but vary in size, ranging from 138 to 481 m in diameter, and 15–45 ms (TWT) depth. The origin of the fluids that contributed to the paleo-pockmark formation is suggested, based on seismic observations, to be biogenic methane. The basin floor fan deposits beneath the interval hosting the paleo-pockmark might have enhanced fluid migration through permeable layers in this basin-fill. This model can help to explain pockmark formation in deep water sedimentary systems, and may inform future studies of fluid migration and expulsion in sediment sinks.
Peripheral and Autonomic Neuropathy Status of Young Patients With Type 1 Diabetes Mellitus at the Time of Transition From Pediatric Care to Adult-Oriented Diabetes Care
Authors: Vágvölgyi Anna , Maróti Ágnes , Szűcs Mónika , Póczik Csongor , Urbán-Pap Dóra , Baczkó István , Nemes Attila , Csajbók Éva , Sepp Krisztián , Kempler Péter , Orosz Andrea , Várkonyi Tamás , Lengyel Csaba 
Published: September 2021

IntroductionThe prevalence of neuropathic lesions in young patients with type 1 diabetes mellitus (T1DM) at the time of transition from pediatric care to adult-oriented diabetes care is poorly studied. A comparative study with healthy volunteers to assess the possible neuropathic condition of this special population and to identify the potential early screening needs has not been performed yet. The results may provide important feedback to pediatric diabetes care and a remarkable baseline reference point for further follow up in adult diabetes care.Patients and MethodsTwenty-nine young patients with T1DM [age: 22.4 ± 2.9 years; HbA1c: 8.5 ± 2.1%, diabetes duration: 12.2 ± 5.8 years; (mean ± SD)] and 30 healthy volunteers (age: 21.5 ± 1.6 years; HbA1c: 5.3 ± 0.3%) were involved in the study. Autonomic function was assessed by standard cardiovascular reflex tests. Complex peripheral neuropathic testing was performed by Neurometer®, Neuropad®-test, Tiptherm®, Monofilament®, and Rydel-Seiffer tuning fork tests.ResultsT1DM patients had significantly higher diastolic blood pressure than controls (80 ± 9 vs. 74 ± 8 mmHg, p &lt; 0.01), but there was no significant difference in systolic blood pressure (127 ± 26 vs. 121 ± 13 mmHg). Cardiovascular reflex tests had not revealed any significant differences between the T1DM patients and controls. No significant differences with Neurometer®, Neuropad®-test, and Monofilament® were detected between the two groups. The vibrational sensing on the radius on both sides was significantly impaired in the T1DM group compared to the controls with Rydel-Seiffer tuning fork test (right: 7.5 ± 1.0 vs. 7.9 ± 0.3; left: 7.5 ± 0.9 vs. 7.9 ± 0.3, p &lt; 0.05). The Tiptherm®-test also identified a significant impairment in T1DM patients (11 sensing failures vs. 1, p &lt; 0.001). In addition, the neuropathic complaints were significantly more frequently present in the T1DM patient group than in the controls (9 vs. 0, p &lt; 0.01).ConclusionIn this young T1DM population, cardiovascular autonomic neuropathy and cardiac morphological alterations could not be found. However, Rydel-Seiffer tuning fork and Tiptherm®-tests revealed peripheral sensory neurological impairments in young T1DM patients at the time of their transition to adult diabetes care.
Brain-Derived Neurotropic Factor, Vascular Endothelial Growth Factor and Matrix Metalloproteinases as Markers of Metabolic Status in Non-Growth Hormone-Treated Girls With Turner Syndrome
Authors: Błaszczyk Ewa , Gawlik Jakub , Gieburowska Joanna , Tokarska Agnieszka , Kimsa-Furdzik Małgorzata , Hibner Grzegorz , Francuz Tomasz , Gawlik Aneta Monika 
Published: September 2021

BackgroundTurner syndrome (TS) presents a high risk of congenital heart defects and may predispose to both obesity and related metabolic complications. Hence the search for new markers as potential early predictors of the metabolic syndrome (MetS) and cardiovascular diseases appears warranted.ObjectiveTo assess MMP-1 (matrix metalloproteinase-1), MMP-2 (matrix metalloproteinase-2), MMP-9 (matrix metallopeptidase-9), BDNF (brain-derived neurotrophic factor), GDNF (glial cell line-derived neurotrophic factor), and VEGF (vascular endothelial growth factor) in non-MetS TS girls not treated with growth hormone (GH) vs. healthy short stature girls, and to assess the connection with basic metabolic parameters.MethodThe concentrations of circulating MMP-1, MMP-2, MMP-9, BDNF, GDNF and VEGF were measured in 12 patients with TS not treated with growth hormone. The control group was composed of 17 girls with non-pathologic short stature. The patients’ clinical and biochemical phenotypes were determined by weight, height, total cholesterol, HDL cholesterol, triglycerides, glucose, aminotransferases, IGF1, TSH and fT4.ResultsThere were no differences in mean age, weight, BMI Z-Score, or hSDS between the studied group and the controls; however, they differed in baseline values of ALT (18.2 ± 4.2 vs. 14.2 ± 4.1, p= 0.02), BDNF [29951.5 (26176.9 – 41271.9) vs. 23131.7 (18392.4 – 28313.3), p=0.01] and MMP-2 [91.8 (71.7 – 111.0) vs. 143.6 (123.7 - 244.5), p&lt; 0.001]. BDNF correlated with ALT activity (r = 0.56 p = 0.002) and BMI Z-score (r = 0.38 p = 0.042), while MMP-2 correlated with HDL concentration (r = 0.48 p = 0.029) in all the patients. The analysis of the study group alone revealed significant positive correlations between MMP-9 and TSH (r = 0.74 p = 0.036), BDNF and both ALT (r = 0.73 p = 0.038) and TSH (r = 0.85 p = 0.008), and a negative correlation between MMP-1 and fT4 (r = -0.75 p = 0.032). The control group did not present any significant correlations.ConclusionThe higher concentrations of BDNF and lower of MMP-2 found in girls with TS without MetS compared to healthy girls with short stature, could have a major impact on the future “natural” development of the metabolic status. Our findings need further studies.
Case Report: A Boy From a Consanguineous Family Diagnosed With Congenital Muscular Dystrophy Caused by Integrin Alpha 7 (ITGA7) Mutation
Authors: Xia Wenqing , Ni Zhumei , Zhang Zheng , Sang Hongfei , Liu Huifang , Chen Zhenzhen , Jiang Lin , Yin Congguo , Huang Jinyu , Li Lingfei , Lei Xiaoguang 
Published: September 2021

Introduction: Congenital muscular dystrophy (CMD) is a group of early-onset disorders with clinical and genetic heterogeneity. Patients always present with muscle weakness typically from birth to early infancy, delay or arrest of gross motor development, and joint and/or spinal rigidity. There are various genes related to the development of CMD. Among them, mutations in integrin alpha 7 (ITGA7) is a rare subtype. The identification of disease-causing genes facilitates the diagnosis and treatment of CMD.Methods: We screened ITGA7 mutations in four people by whole exome sequencing and targeted sequencing from a consanguineous family. We then carried out electromyography and neuroelectrophysiological examinations to clarify a clinical picture of the patient diagnosed with CMD.Results: We report a Chinese boy diagnosed with CMD who carries a homozygous variant (c.1088dupG, p.H364Sfs*15) of the ITGA7 gene. According to the genotype analysis of his family members, this is an autosomal recessive inheritance.Conclusions: Our case further shows that ITGA7 mutation is related to CMD. Genetic counseling and multidisciplinary management of CMD play an important role in helping patients and their family. Further elucidation of the significant clinical and genetic heterogeneity, therapeutic targets, and the clinical care for patients remains our challenge for the future.
Properdin Deficiency Impairs Phagocytosis and Enhances Injury at Kidney Repair Phase Post Ischemia–Reperfusion
Authors: Wu Yuanyuan , Zwaini Zinah D. , Brunskill Nigel J. , Zhang Xinyue , Wang Hui , Chana Ravinder , Stover Cordula M. , Yang Bin 
Published: September 2021

Properdin, a positive regulator of complement alternative pathway, participates in renal ischemia–reperfusion (IR) injury and also acts as a pattern-recognition molecule affecting apoptotic T-cell clearance. However, the role of properdin in tubular epithelial cells (TECs) at the repair phase post IR injury is not well defined. This study revealed that properdin knockout (PKO) mice exhibited greater injury in renal function and histology than wild-type (WT) mice post 72-h IR, with more apoptotic cells and macrophages in tubular lumina, increased active caspase-3 and HMGB1, but better histological structure at 24 h. Raised erythropoietin receptor by IR was furthered by PKOand positively correlated with injury and repair markers. Properdin in WT kidneys was also upregulated by IR, while H2O2-increased properdin in TECs was reduced by its small-interfering RNA (siRNA), with raised HMGB1 and apoptosis. Moreover, the phagocytic ability of WT TECs, analyzed by pHrodoEscherichia colibioparticles, was promoted by H2O2but inhibited by PKO. These results were confirmed by counting phagocytosed H2O2-induced apoptotic TECs byin situend labeling fragmented DNAs but not affected by additional serum with/without properdin. Taken together, PKOresults in impaired phagocytosis at the repair phase post renal IR injury. Properdin locally produced by TECs plays crucial roles in optimizing damaged cells and regulating phagocytic ability of TECs to effectively clear apoptotic cells and reduce inflammation.