bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a Complex Intervention to Support Parents of Chronically Ill Adolescents in Transition From Pediatrics to Adult Care (ParTNer-STEPs)
Authors: Thomsen Ena Lindhart , Esbensen Bente Appel , Hanghøj Signe , Hansson Helena , Boisen Kirsten Arntz 
Published: December 2021

Abstract
Background Transfer from pediatric to adult care for chronically ill adolescents is associated with outpatient non-attendance and low treatment adherence in adolescents, and with anxiety and concerns among parents. Recent studies have shown that parent involvement results in better transitions. The aim of this paper was to describe the development, through participatory design, of a brief transition program targeted to parents of chronically ill adolescents.Methods The study was based on the UK Medical Research Council’s (MRC) framework on developing and testing complex interventions. To increase the program’s feasibility and relevance, participatory design was chosen as the overall method. A collaboration group of parents, adolescents and health care professionals (HCP) were actively involved in the development of the program. The program was developed in three development stages, in accordance with the MRC framework: 1) identifying the evidence base, 2) identifying theory, and 3) modelling process and outcomes. Results Together with the collaboration group, we developed a brief transition program targeting parents, by undertaking an iterative process, involving a literature review, individual interviews, workshops, online brainstorms and multiple pilot tests. The program, called ParTNer-STEPs (Parents in Transition – a Nurse-led Support and Transfer Educational Program) comprised three components: 1) an informative website, 2) online educational events for parents, and 3) transfer consultations with providers from both pediatrics and adult care.Conclusions The MRC framework was successfully applied to develop a brief transition program targeting parents of chronically ill adolescents. By incorporating the principles of participatory design in the development phase, we ensured that both parents’ and adolescents’ needs were represented and addressed in the program. Furthermore, the involvement of HCPs ensured the feasibility and relevance of the intervention in clinical practice and will increase the chances of successful implementation.Trial registration ClinicalTrials.gov ID NCT04969328
Genetic Algorithm-Based Hybrid Spectrum Handoff Strategy in Cognitive Radio-Based Internet of Things
Authors: Miao Liu , Qing He , Huo Zhuo-Miao , Sun Zhen-Xing , Di Xu 
Published: December 2021

Abstract
In Cognitive radio-based Internet of Things (CR-IoT) systems, the return of the primary user (PU) causes the secondary user (SU) that is communicating to face the spectrum handoff problem. In the process of spectrum handoff, the user terminal can’t get the idle channels in time because of the unknown channel usage state.
To solve this problem, a hybrid spectrum handoff algorithm based on the channel idle probability is proposed. The
algorithm considers the regularity of PU activities in space and time, defines the idle probability of channels from
the perspective of week attributes and time periods, obtains the optimal time period length using genetic algorithm, generates a channel idle probability table, and provides the target channel sequence for SUs in combination with the proposed channel ordering scheme. Simulation results show that the hybrid spectrum switching algorithm based on the channel idle probability can reduce the energy consumption of SUs during spectrum switching, reduce the communication interruption rate, enable SUs to find idle channels faster and reduce the number of sensing times.
Trends of overweight and obesity among preschool children from 2013 to 2018: A cross-sectional study in Rhine-Neckar County and the City of Heidelberg, Germany
Authors: Liu Weina , Dambach Peter , He Mike Z. , Schwertz Rainer , Chen Simiao , Yu Fengyun , Marx Michael 
Published: December 2021

Abstract
BackgroundEarly childhood overweight and obesity is a growing public health concern worldwide. Few recent studies have addressed how time trends varied by sociodemographic characteristics at the regional level using large and high-quality data. This study aims to determine how time trends vary in the prevalence of early childhood overweight and obesity by age, gender, and migration background at the regional level.MethodsWe described the distribution change in the BMI with a Kernel-density curve, and evaluated the trends of overweight and obesity by age, gender, and migration background using logistic regression.ResultsMean BMI and the prevalence of overweight and obesity increased among preschool children aged 4-6 years in the Rhine-Neckar County and the City of Heidelberg. After adjusting for age, gender, and migration background, trends in the prevelance of overweight significantly increased only among male children in the age 5 year group with migration background (P < 0.05), and an upward trend of obesity was observed only among male children in the age 5 year group and female children in the age 6 year group with migration background (P < 0.05).Conclusions﻿BMI distribution as well as general prevalence of overweight and obesity are still increasing among preschool children. Children with migration backgrounds, particularly male children in the age 5 year groups and female children in the age 6 year group should be prioritized. More prevention policies should be targeted towards vulnerable groups.
Field Study for PAH Absorption Performances of Butyl Rubber, PDMS, and SPMD Passive Samplers
Authors: Tureyen Oktay Eren , Yakan Sevil Deniz , Yilmaz Atilla , Yetiskin Berkant , Okay Oguz , Okay Oya S. 
Published: December 2021

Abstract
Polycyclic aromatic hydrocarbons (PAHs) are organic pollutants having various adverse effects on the marine ecosystem. Because of their low solubility in the marine environment, their detection and monitoring in the water column are challenging tasks. Passive samplers are used to detect PAHs in aquatic environments as complementary tools to conventional water sampling. In the present study, PAH absorbance performances of four butyl rubber-based (BR) passive samplers with different structures (SN5, SN10, DN, and TN) and commercialized passive samplers (SPMD and PDMS) were determined. Stainless steel cages containing passive samplers were deployed in the water column in Istinye Bay, Istanbul, and retrieved after 7 and 28 days. Collected samplers were analyzed in the laboratory to determine their PAH contents. Results showed that, even though the SPMD samplers had the highest total PAH content, they were not able to collect PAHs with log Kow value of above 6.0. Similarly, PAHs with log Kow values higher than 5.5 could have not been collected by PDMS samplers. In contrast, BR-based passive samplers have sampled also high molecular weight PAHs in the water column, and SN10 sampler showed the highest performance in terms of the collected PAHs. Results highlighted that SN10 sampler has a wide absorption range when it is compared with the commercialized samplers, and it has also advanced absorption performance relative to the other BR samplers.
Where’S the “Everyday Black Woman”? an Intersectional Qualitative Analysis of Black Women’S Decision-Making Regarding HIV Pre-Exposure Prophylaxis (PrEP) in Mississippi
Authors: Willie Tiara C. , Knight Deja , Baral Stefan D. , Chan Philip A. , Kershaw Trace , Mayer Kenneth H. , Stockman Jamila K. , Adimora Adaora A. , Monger Mauda , Mena Leandro A. , Philllips Karlye A. , Nunn Amy 
Published: December 2021

Abstract
Background

Black cisgender women in the U.S. South bear a disproportionate burden of HIV compared to cisgender women in other racial and ethnic groups and in any other part of the US. Critical to decreasing new HIV infections is the improved delivery of pre-exposure prophylaxis (PrEP) for Black cisgender women as it remains underutilized in 2021. Informed by intersectionality, the study sought to characterize the sociostructural influences on Black cisgender women’s deliberations about PrEP within the context of interlocking systems of oppression including racism, sexism, and classism.
Methods

Six focus groups were conducted with 37 Black women residing in Jackson, Mississippi. This sample was purposively recruited to include Black cisgender women who were eligible for PrEP but had never received a PrEP prescription.
Results

Six themes were identified as obstacles during PrEP deliberation among Black women: 1) limited PrEP awareness, 2) low perceived HIV risk, 3) concerns about side effects, 4) concerns about costs, 5) limited marketing, and 6) distrust in the healthcare system. Three themes were identified as facilitators during PrEP deliberations: 1) women’s empowerment and advocacy, 2) need for increased PrEP-specific education, and 3) the positive influence of PrEP-engaged women’s testimonials. Black women shared a limited awareness of PrEP exacerbated by the lack of Black women-specific marketing. Opportunities to support Black women-specific social marketing could increase awareness and knowledge regarding PrEP’s benefits and costs. Black women also shared their concerns about discrimination in healthcare and distrust, but they felt that these barriers may be addressed by patient testimonials from PrEP-engaged Black women, empowerment strategies, and directly addressing provider biases.
Conclusions

An effective response to PrEP implementation among Black women in the South requires developing programs to center the needs of Black women and carry out active strategies that prioritize peer advocacy while reinforcing positive and mitigating negative influences from broader social and historical contexts.
Phytochemical, Heavy Metals and Antimicrobial Study of the Leaves of Calopogonium Mucunoides
Authors: Emenike Ebuka Chizitere , Chukwuebuka Onyema 
Published: December 2021

Abstract
Background: In this study, the phytochemical, heavy metals, and antimicrobial characteristics of the leaves of Calopogonium mucunoides were investigated in other to determine its therapeutic potentials. The phytochemicals present in the leaves were extracted with n-hexane, methanol and ethyl acetate, and the extracts were used to investigate for the phytochemical constituents and antimicrobial activity. The methanol extract was used to test for the concentration of five heavy metals.Results: The result of the phytochemical screening confirmed the presence of alkaloids, anthocyanins, flavonoids, glycosides, phenols, reducing sugars, saponins, steroids, tannins, and terpenoids in various quantities. The heavy metals analysis result revealed the presence of lead (0.08 mg/kg) and iron (0.08 mg/kg) well below the acceptable limits set by the World Health Organization for heavy metals in plants, while cadmium, nickel and zinc were found to be below detectable limits. The extracts were tested against thirteen human pathogens (ten bacteria and three fungi) using the disk diffusion method. The extracts possessed a broad range of microbial activities, with the methanolic extract reportedly showing the highest zone of inhibition (31 mm) against Bacillus sp. while the n-hexane extract did not show any antimicrobial activity in the whole test organisms.Conclusion: The results obtained revealed that the leaves of C. mucunoides has some therapeutic values and could be exploited in the preparation of herbal drugs for the treatment of various ailments.
Peripheral Interleukin-18 Is Negatively Correlated With Abnormal Brain Activity In Patients With Depression: A Resting-State fMRI Study
Authors: Du Xiangdong , Zou Siyun , Yue Yan , Fang Xiaojia , Wu Yuxuan , Wu Siqi , Wang Haitao , Li Zhe , Zhao Xueli , Yin Ming , Ye Gang , Sun Hongyan , Gu Xiaochu , Zhang Xiaobin , Miao Zhigang , Jin Jeff Wang , Wu Hanjing Emily , Liu Yansong , Xu Xingshun 
Published: December 2021

Abstract
Background: Interleukin-18 (IL-18) may participate in the development of major depressive disorder, but the specific mechanism remains unclear. This study aimed to explore whether IL-18 correlates with areas of the brain associated with depression.Methods: Using a case-control design, 68 subjects (34 patients and 34 healthy controls) underwent clinical assessment, blood sampling, and resting-state functional Magnetic Resonance Imaging (fMRI). The total Hamilton depression-17 (HAMD-17) score was used to assess depression severity. Enzyme-linked immunosorbent assay (ELISA) was used to detect IL-18 levels. Rest-state fMRI was conducted to explore the spontaneous brain activity. Results: The level of IL-18 was higher in patients with depression in comparison with health controls. IL-18 and degree centrality (DC) were negatively correlated with the left posterior cingulate gyrus in the depression patient group, but no correlation was found in the healthy control group. Conclusion: This study suggests the involvement of IL-18 in the pathophysiological mechanism for depression and interference with brain activity.
Lysozyme Treatment Makes 16S rRNA Amplicon Sequencing Results Less Biased
Authors: Jiao Yuting , Gao Zijie , Gui Shiyu , Ren Lu , Lu Yongyue , Cheng Daifeng 
Published: December 2021

Abstract
Background

Amplicon sequencing is widely applied in gut bacteria structure analysis. However, the proportion of Gram-positive bacteria may greatly affect the results of microbial community analysis. Lysozyme is an effective agent to extract DNA of Gram-positive bacteria. In this study, we assessed the influence of lysozyme treatment on results of Bactrocere dorsalis rectal bacteria structure.
Result

The results indicated that the total bacteria content can be significantly increased in lysozyme treated samples. Moreover, rectal bacteria diversity was significantly higher in lysozyme treated samples. A detail analysis revealed that abundance of Gram-positive bacteria significantly increased in samples treated with lysozyme.
Conclusion

This study indicates that lysozyme treatment before DNA extraction is an effective way to reduce bias in bacteria structure analysis, especially for samples with high proportion of Gram-positive bacteria.
Mitophagy Eliminates the Accumulation of SARM1 on the Mitochondria, Alleviating Axon Degeneration in Acrylamide Neuropathy
Authors: Wang Shuai , Yong Hui , Zhang Cuiqin , Kang Kang , Song Mingxue , Yang Yiyu , Huang Zhengcheng , Wang Shu’e , Ge Haotong , Zhao Xiulan , Song Fuyong 
Published: December 2021

Abstract
Background: Sterile-α and toll/interleukin 1 receptor motif containing protein 1 (SARM1) is the central executioner of axon degeneration. Although it has been confirmed to have a mitochondrial targeting sequence and can bind to and stabilize PINK1 on depolarized mitochondria, the biological significance for mitochondrial localization of SARM1 is still unclear. Chronic acrylamide (ACR) intoxication can cause typical pathology of axonal injury, owning the potential to explore the interaction between mitochondria and SARM1 during the latent period of axon destruction.Methods: The expression and the mitochondria distribution of SARM1 were evaluated in in vivo and in vitro ACR neuropathy models. Transmission electron microscopy, immunoblotting, and immunofluorescence were performed to evaluate mitochondrial dynamics and PINK1-dependent mitophagy. LC3 turnover experiment and live cell imaging were conducted to further assess the state of mitophagy flux. In order to verify the effect of mitophagy in SARM1-mediated axon degeneration, low-dose and low-frequency rapamycin was administered in ACR-exposed rats to increase basal autophagy.Results: In a time- and dose-dependent manner, ACR induced peripheral nerve injury in rats and truncated axons of differentiated N2a cell. Moreover, the severity of this axon damage was consistent with the up-regulation of SARM1. SARM1 prominently accumulated on mitochondria, and at the same time mitophagy was activated. Importantly, rapamycin (RAPA) administration eliminated mitochondrial accumulated SARM1 and alleviated SARM1 dependent axonal degeneration.Conclusions: Complementing to the coordinated activity of NMNAT2 and SARM1, mitochondrial localization of SARM1 may be part of the self-limiting molecular mechanisms of Wallerian axon destruction. In the early latent period of axon damage, the mitochondrial localization of SARM1 will help it to be isolated by the mitochondrial network and to be degraded through PINK1-dependent mitophagy to maintain local axon homeostasis. When the mitochondrial quality control mechanisms are broken down, SARM1 will cause irreversible damage for axon degeneration. Moderate autophagy activation can be invoked as potential strategies to alleviate axon degeneration in ACR neuropathy and even other axon degeneration diseases.
Application of CT Radiomics Combined with Machine Learning Methods in Predicting the Recurrence or Metastasis of Gastrointestinal Stromal Tumors
Authors: Feng Qiu-Xia , Xu Lu-Lu , Li Qiong , Jiang Xiao-Ting , Tang Bo , Zhang Yu-Dong , Liu Xi-Sheng 
Published: December 2021

Abstract
Background

The study aimed to evaluate the diagnostic performance of machine learning-based CT radiomics models for predicting the recurrence and metastasis of gastrointestinal stromal tumors (GISTs) preoperatively.
Methods

A total of 382 patients with histopathological confirmed GISTs were retrospectively included. According to postoperative follow-up, patients were classified into non-recurrence and metastasis group (NRM) and recurrence or metastasis group (RM). Radiomics features were extracted from arterial and portal venous phase CT images. Four feature selection methods and ten machine learning techniques were used to train predicting models on training cohort with internal validation by 10-fold cross-validation. F1 score was used to evaluate the performance of the classification model. The best model of two phase were stacked to build an ensemble model. The area under the curve (AUC), recall, precision, accuracy, and F1 score were used to evaluate the performance of the models and compare with clinical criteria based on diameter.
Results

Eighty machine learning models in two phases were built and the ensemble model was integrated by analysis of variance and Naive Bayes (ANOVA_NB) model in arterial phase which selected only 5 features provided the highest F1 Score of 0.560 and Kruskal Wallis and Adaptive Boosting (KW_ AdaBoost) model in venous phase which selected only 4 features provided the highest F1 Score of 0.500. The AUC of the generated ensemble model and the clinical criteria showed no difference (0.866 vs 0.857; DeLong Test, P = 0.865). But the ensemble model had higher accuracy (0.961), recall (0.826), precision (0.905), F1 Score (0.864), and the area under the Precision-Recall curve (0.774; 95%CI, 0.552 - 0.917), compared with clinical criteria, of which, the accuracy was 0.942, recall was 0.367, precision was 0.478, the F1 Score was 0.415 and the area under the Precision-Recall curve was 0.354(95%CI, 0.552 - 0.917).
Conclusions

Our findings highlight the potential of machine learning techniques based on CT radiomics in the prediction of recurrence and metastasis of GISTs preoperatively.
The mNUTRIC Score as a Tool to Predict Mortality and Increased Resource Utilization in Intensive Care Patients with Sepsis.
Authors: Wełna Marek , Kübler Andrzej , Goździk Waldemar , Adamik Barbara 
Published: December 2021

Abstract
Background: The mNUTRIC score is a nutrition risk assessment tool. The aim of this study was to evaluate mNUTRIC score ability to predict 28-mortality, icu resource utilization and nursing workload for patients with sepsis and septic shock. Methods: We performed a secondary analysis of prospectively collected data from a ICU sepsis registry database. The study included adults diagnosed with sepsis or septic shock, admitted from January to December 2014.Results: The study included 146 patients. In the ROC curve analysis the mNUTRIC score had the ability to predict 28-day mortality with an AUC of 0.833 (95% CI 0.76-0.89). Additionally group of patients with NUTRIC score ≥ 6 points more frequently required vasopressor infusion, mechanical ventilation, renal replacement therapy, thromboprophylaxis and blood products use. Nursing workload was also significantly higher in this group (TISS-28: 36 pts., IQR 33 – 40 vs. 31 pts, IQR 28 – 34, p<0.001).Conclusion: The mNUTRIC score obtained at admission to the ICU provided a good discriminative value for 28-mortality and makes it possible to identify patients who will ultimately require intense use of ICU resources with an associated increase in the nursing workload during ICU sepsis treatment.
A systematic review of blue carbon as an approach for Eco-DRR: current gap and future research
Authors: Ogunwumi Taiwo Seun , Armstrong Margarethe-Elizabeth Graves 
Published: December 2021

Abstract
Blue carbon ecosystems (BCEs), such as wetlands, marshes, mangroves, and seagrasses, warrant increased attention for their abilities to protect life, property, and environments locally and globally. BCEs serve as both buffers reducing coastal hazards and carbon sinks storing ‘blue’ carbon in aquatic plant life and soils. While research exists on BCE functions and benefits, their global diversity necessitates a collection of localized research investigating the unique dynamics and histories of distinct BCEs. The historic degradation of coastal ecosystems proves the need for purposeful, well-informed, sustainable ecosystem management to conserve and restore BCEs. We conducted a systematic literature review to understand the existing body of research on synergies between BCEs and ecosystem-based disaster risk reduction (Eco-DRR). We investigated how prior research employed various research methods, discussed key aspects of sustainable land management, and considered geographic locations and scales. We discovered localized case studies have incredible insights on the efficacy of BCEs along with context-specific strategies for sustainable ecosystem management. However, as these case studies are not plentiful and are concentrated in North America and Asia, they do not account for the diversity of BCEs. We suggest increased support for localized research on the benefits and implementation of BCEs as Eco-DRR measures.