bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forming an individual trajectory of teaching computer-aided design by means of an intelligent adaptive system
Authors: Hoang Cong , Avksentieva Elena , Fedosov Yuriy 
Published: March 2021

The aim of the work is to increase the efficiency of teaching computer-aided design of printed circuit boards of ship integrated control systems (CAD PCB SICS) with forming an individual learning path, in which there is a need to move from traditional teaching to intelligent adaptive training.
The research method is to analyze the peculiarities of forming an individual trajectory of teaching CAD PCB.
Research results and novelty:
an algorithm for implementing the training course at intelligent adaptive teaching CAD PCB SICS is developed; an algorithm for determining the complexity level of educational material for teaching CAD PCB by study priority is developed; Kohonen's algorithm for forming an intelligent adaptive environment of the educational process of teaching CAD PCB SICS is considered; an algorithm for adaptive testing with forming individual trajectories of teaching CAD PCB SICS is developed taking into account the student’s preferences and individual characteristics.
Helminth fauna of birds of prey (Strigiformes: Strigidae, Tytonidae) in the Non-Black Earth Region of the Russian Federation
Authors: Dorokhov V. V. , Davydova O. E. 
Published: March 2021

The purpose of the research is studying helminths of carnivorous birds of the order of owls (Strigiformes) found in the Non-Black Earth Region of the Russian Federation.Materials and methods. From 2015 to 2020, complete helminthological dissections were carried out by the Skryabin method for 72 birds of the order of owls after their spontaneous death: 8 specimens of the short-eared owl Asio flammeus, 6 specimens of the Ural owl Strix uralensis, 4 specimens of the little owl Athene noctua, 9 specimens of the barn owl Tyto alba, 19 specimens of the tawny owl S. aluco, and 26 specimens of the long-eared owl A. otus. The study material was provided by rehabilitation centers and veterinary clinics in Moscow City and the Moscow, Tula and Kaluga regions. The helminths were fixed according to generally accepted methods; the species was identified taking into account specific morphological characters.Results and discussion. Total infection rate in owls was 89.9%. All studied birds were found to have mixed infections with two or more types of helminths. We identified 15 helminth species including 3 species of trematodes (Neodiplostomum attenuatum, Strigea falconis, S. strigis), 2 species of cestodes (Cladotaenia globifera, Paruterina candelabraria), 9 species of nematodes (Syngamus trachea, Cyrnea leptoptera, Microtetrameres inermis, Synhimantus laticeps, Porrocaecum depressum, P. spirale, Capillaria tenuissima, Baruscapillaria falconis, and Capillaria sp.) and 1 acanthocephalian species (Centrorhynchus aluconis). For the first time, new hosts were identified for the following helminth species: the barn owl, short-eared owl and little owl for the trematode N. attenuatum, the Ural owl and little owl for S. falconis, the long-eared owl for the nematode S. trachea, the short-eared owl and tawny owl for C. leptoptera, and the tawny owl for M. inermis.
Coexistence of Lateriporus teres (Cestoda: Dilepididae) and Polymorphus phippsi (Palaeacanthocephala: Polymorphidae) in the intestine of common eider
Authors: Kuklina М. М. , Kuklin V. V. 
Published: March 2021

The purpose of the research is studying the peculiarities of parasite infection of the cestodes Lateriporus teres Krabbe, 1869 (Cestoda: Dilepididae) and acanthocephalans Polymorphus phippsi Kostylew, 1922 (Palaeacanthocephala: Polymorphidae) during coexistence in the intestine of the common eider, particularly, the localization of these parasites, the activity of protein and carbohydrate metabolism enzymes on the tegument of the worms, the degree of parasite influence on the host digestion, as well as to assess total digestive activity in the gastrointestinal tract of birds infected with these helminths.Materials and methods. Using methods of biochemical analysis, the activity of digestive enzymes (protease and glycosidase) and the intensity of a digestion with the participation of these enzymes along the intestine of the common eider were determined. The digestive activity of enzymes in the body of helminthes was measured, and the intensity of membrane digestion on the surface of their tegument was estimated.Results and discussion. During coexistence, L. teres were observed mainly in the proximal parts of the intestine of the birds, P. phippsi in the distal parts. Membrane digestion, involving the action of proteases and glycosidases, occurred on the surface of the tegument of both cestodes and acanthocephalans. The protein metabolism intensity in both helminth species was nearly the same, but the glycosidase activity was higher on the tegument of L. teres. The glycosidase activity in the body of the acanthocephalans exceeded that in the cestodes strobile six times. In the intestine parts inhabited by L. teres, both protease and glycosidase activity decreased. In the intestine parts where P. phippsi parasitized, protease activity increased in the intestinal mucosa of the common eider. The total activity of protease and glycosidase along the entire length of the intestine in common eider infected with L. teres and P. phippsi was lower compared to the uninfected birds.
Study of the peculiarities of combined opisthorchosis and helicobacteriosis
Authors: Bibik O. I. , Pomytkina T. E. , Pivovar O. I. 
Published: March 2021

The purpose of the research is identifying patients with helicobacteriosis and opisthorchosis, and determining regular features of the course of combined diseases.Materials and methods. The study involved 50 patients in the Gastroenterology Department with helicobacteriosis diagnosed. Helicobacter pylori was confirmed by the HP test during fibrogastroduodenoscopy. Opisthorchis felineus was detected in patients using the study of feces by the Kato technique and enrichment method. The patients were divided into 2 groups of 25 people each. The first group only consisted of patients with H. pylori. The second group consisted of patients in whom H. pуlori and O. felineus were identified. Initially, the levels of aminotransferases and bilirubin were assessed using a biochemical blood test on a MIURA 200 apparatus. The manifestation of such clinical symptoms as abdominal pain was assessed using a visual analogue scale (VAS). Further, the eradication of H. pylori during therapy was assessed based on the Maastricht V recommendations for 14 days, including the use of three drugs: omeprazole at a dose of 20 mg 2 times a day, clarithromycin – 500 mg 2 times a day, amoxicillin – 1000 mg 2 times a day, and the effectivity of treatment of patients of the second group with opisthorchosis with the use of praziquantel at a dose of 60 mg/kg of body weight during the day three times every 4 hours.Results and discussion. In the second group of patients with combined pathology, pain intensity was estimated at 4–5 scores in 20 people (80%), and at 2–3 scores in 25 people (100%) in the first group. The severity of nausea was also higher in 100% of patients in the second group. Values for AST and ALT in blood were higher in patients of the second group – by an average of 50–100% in 18 people (72%); increase in the level of bilirubin by 15% in 23 people (92%). Combined pathology (opisthorchosis and helicobacteriosis) is accompanied by more pronounced clinical symptoms (abdominal pain and nausea). In patients with opisthorchosis and H. pуlori, aminotransferases increased up to three reference values and bilirubin increased by 15% were noted. For helicobacteriosis and opisthorchosis, longer treatment was required. The presence of H. pylori at the same time with opisthorchosis did not affect the efficacy of antiparasitic therapy.
The efficacy of FOS and Fitoverm drugs against Ixodes ticks
Authors: Butakov E. I. , Shamanskaya L. D. 
Published: March 2021

The purpose of the research is studying the efficacy of FOS and Fitoverm drugs against ixodid ticks.Materials and methods. The study objects were ixodid tick species Ixodes persulcatus (Schulze, 1930), Dermacentor reticulatus (Hermann, 1804) and D. marginatus (Schulzer, 1776) in the imago stage. Ticks were collected in the environment of the Altai plains and mountains from vegetation to the flag under the methodology. The efficacy of drug acaricidal activity was assessed according to the methodological guide. In the laboratory, the ticks were placed in a chamber at a temperature of 7 оC. The effect of drugs was assessed by observation every hour for 2-3 days. Live ticks (20 individuals) were contacted with the drug by immersion three times in the working solution in a permeable fabric container. Neostomosan was used as control. Further tests of FOS and Fitoverm were carried out in the field environment. Briz 25% e.c. was used as control. The plots on which the number of Ixodes had previously been recorded was treated using a sprayer on June 1-2 in the morning. The number of live ticks in the plots was counted 1-2 days after the treatment. The biochemical composition of grass stand on various treated grounds was studied according to standard methods. The results were processed statistically.Results and discussion. The Siberian Scientific-Research Institute of Horticulture has developed a series of environmentally friendly drugs based on natural biologically active substances that have shown high efficacy against Ixodes. These are FOS and Fitoverm, which provided a 100% lethal effect against Ixodes in working concentrations of 3–4% and 0.1–0.3% under laboratory conditions. Treatment with Fitoverm 0.3%, FOS 3% and synthetic industrial drug Briz 25% of e.c. 0.75% of grass stand at the stage of grazing for cattle in pasture conditions statistically significantly reduces the number of ticks by 71–79%.
Orientasi Pasar dalam Inovasi Produk dan Kinerja Bisnis Perbankan
Authors: Harianto Raden A , Sari Pratiwi Nila 
Published: March 2021

Tujuan penelitian ini adalah untuk mengetahui pengaruh Orientasi Pasar dan Inovasi Produk terhadap Kinerja Bisnis Perbankan, di Jakarta. Metode penelitian ini menggunakan metode survei kausal dengan pendekatan kuantitatif. Populasi target dalam penelitian ini adalah sebanyak 50 Bank (N = 50) di DKI Jakarta. Teknik sampling yang digunakan adalah teknik simple random sampling dan jumlah sampel dari penelitian ini adalah n = 99 responden. Pengumpulan data primer menggunakan metode kuesioner. Data dianalisis menggunakan analisis Jalur (path analysis) lewat Software Lisrel 8.54. Hasil dari penelitian ini adalah bahwa (1) Terdapat pengaruh langsung positif signifikan orientasi pasar terhadap inovasi produk dengan koefisien jalur sebesar p = 0,46 pada α = 0,05; (2) Tidak cukup bukti terdapat pengaruh langsung signifikan orientasi pasar terhadap Kinerja bisnis perbankan dengan koefisien jalur sebesar p = 0,09. (3) Terdapat pengaruh langsung positif signifikan Inovasi Produk terhadap kinerja bisnis perbankan dengan koefisien jalur sebesar p = 0,44 pada α = 0,05 dan (4) Terdapat pengaruh tidak langsung positif signifikan orientasi pasar terhadap kinerja bisnis perbankan melalui inovasi produk dengan koefisien jalur sebesar p = 0,28 pada α = 0,05.
PENINGKATAN KEMAMPUAN BERSAING DI DUNIA KERJA DENGAN PELATIHAN SOFTWARE ZAHIR ACCOUNTING
Authors: Setianingsih Setianingsih , Napisah Napisah , Anisa Anisa , Finatariani Endah , Darsita Ita 
Published: March 2021

Institution Awareness to the citizens in order to increase the quality of education is a part of Tri Dharma Perguruan Tinggi. To apply the program, it needs a plan. Community service program. The general purpose of this community service program is to increase the competency of citizens of RW 003 Babakan Village, Kelapa Dua, Setu, South Tangerang using Zahir Accounting Software training. The activity of this community service program entitled Computerized Accounting. The trainers and the source speakers are from the lecturers of Accounting Major of Pamulang University (Universitas Pamulang). The result conducted on November, 1,2,3 2019 was increasing their ability to use computer and computerized accounting with Zahir Accounting Software. The trainees was enthusiastic with the material they had from the lecturers of Accounting Major of Pamulang University (Universitas Pamulang). The trainees directly used the software.Zahir Accounting Software becomes an attention for the entrepreneurs who need accounting software to support financial noting in their business easily, fast and accurately, so by practicing Zahir Accounting Software will increase the citizens' competence to look for a job Keywords: Software Zahir Accounting ; Computerized Accounting
Impacto da doença periodontal na qualidade de vida: uma revisão integrativa
Authors: Nascimento Júnior Mauro Bezerra do , Nóbrega Fernando José de Oliveira , Fernandes Eloísa Cesário , Andrade Micássio Fernandes de , Oliveira Camila Cristine Araújo de , Fernandes Filho Antônio Eliece , Santos Patrícia Bittencourt Dutra dos 
Published: March 2021

Objetivo: Realizar uma revisão de literatura, com busca sistemática, observando as evidências quanto ao impacto da doença periodontal na qualidade de vida. Metodologia: A pesquisa foi feita nas bases de dados Medline/Pubmed, SciELO, LILACS, Web of Science e Scopus, nas quais utilizou-se os descritores “Periodontal Diseases” e “Quality of Life”. Foram incluídos artigos publicados em português, inglês e espanhol que retrataram a temática no período compreendido entre 2015-2020. Excluiu-se os artigos duplicados e todos os estudos de revisão. Inicialmente, identificou-se 1435 artigos, restando 36 artigos após a observação dos critérios de elegibilidade. Resultados: A doença periodontal causa um impacto negativo na qualidade de vida relacionada à saúde oral, visto que, do total de artigos (n=36), trinta evidenciaram essa afirmativa, e quanto mais severa é a destruição periodontal, pior é a qualidade de vida (n=11). Entretanto, alguns estudos (n=4) não encontraram relações significativas entre a doença e a qualidade de vida ou obtiveram baixo impacto. Além disso, há resultados com alto impacto na qualidade de vida nos seguintes grupos: fumantes, ausência de seguro de saúde, obesos e diabéticos, grávidas, ansiosos, idosos, pacientes com doença renal terminal, cárie, hipertensão arterial. Conclusão: As doenças periodontais interferem negativamente na qualidade de vida das pessoas afetadas e há evidências de quanto maior a severidade da doença, maior é o seu impacto na qualidade de vida. Contudo, são necessários estudos clínicos randomizados e estudos do tipo longitudinal para fortalecer esses achados.
Literature Based Model as an Effort to Build Pedagogic Literacy Ability of Students Elementary School
Authors: Zakaria Zakaria , Mahfud Imam 
Published: March 2021

The literacy learning paradigm must be able to direct students to understand the values ​​of pedagogic literacy. The government policy in the Regulation of the Minister of Education and Culture Number 23 of 2015 proclaims the school literacy movement or Gerakan Literasi Sekolah requiring students to read for 15 minutes as an effort to build a passion for reading, fostering imagination through reading activities with educational messages. Pedagogic literacy values ​​must be built from an early age in an effort to create students with character. One learning model that is considered capable of building students' pedagogic literacy skills is the literature based model. The artile aims to analyze the description of pedagogic literacy in elementary school learning and the didactic design of a literature-based model in building the pedagogic literacy skills of elementary school students. The researchers used the content analysis or meta-analysis method. Sources of data in this study are journals and books related to literature-based models and pedagogic literacy. Then, the object of this research is the didactic design of the literature based model in building the pedagogic literacy skills of elementary school students. The result show that the literature-based model shows an increase in activity students including students' enthusiasm in following lessons, student interaction with teachers, student interaction with students, and student participation in concluding learning.
Keywords: Pedagogic Literacy Ability, Model Pedagogic Literacy, Students Literation
SOX9 Knockdown-Mediated FOXO3 Downregulation Confers Neuroprotection Against Ischemic Brain Injury
Authors: Deng Yiming , Ma Gaoting , Gao Feng , Sun Xuan , Liu Lian , Mo Dapeng , Ma Ning , Song Ligang , Huo Xiaochuan , He Hongwei , Miao Zhongrong 
Published: March 2021

BackgroundEvidence exists uncovering that SRY-box transcription factor 9 (SOX9) plays a role in ischemic brain injury (IBI). Thus, the current study was conducted to elucidate the specific role of SOX9 and the mechanism by which SOX9 influenced IBI.MethodsThe IBI-associated regulatory factors were searched by bioinformatics analysis. The rat model of IBI was generated using middle cerebral artery occlusion (MCAO) treatment. Neuronal cells were exposed to oxygen-glucose deprivation (OGD). The expressions of SOX9, forkhead box O3 (FOXO3), transcription of Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2), and IκB kinase α (IKKα) in OGD-treated neuronal cells were characterized using reverse transcription quantitative polymerase chain reaction (RT-qPCR) assay. The interaction among CITED2, IKKα, and FOXO3 was identified by chromatin immunoprecipitation (ChIP) and dual luciferase reporter gene assays. Gain- and loss-of-function experiments were performed to verify the relationship among SOX9, FOXO3, CITED2, and IKKα and to investigate their functional effects on apoptosis and the inflammatory response of OGD-treated neuronal cells as well as neurological deficit and infarct area of the rat brain.ResultsSOX9, FOXO3, CITED2, and IKKα were highly expressed in OGD-treated neuronal cells. Silencing of SOX9 inhibited OGD-induced neuronal apoptosis and inflammatory response and reduced the neurological deficit and infarct area of the brain in the rats, which were caused by MCAO but were reversed by overexpressing FOXO3, CITED2, or IKKα.ConclusionTaken together, our study suggested that upregulation of SOX9 promoted IBI though upregulation of the FOXO3/CITED2/IKKα axis, highlighting a basic therapeutic consideration for IBI treatment.
A Genetic Risk Score Improves the Prediction of Type 2 Diabetes Mellitus in Mexican Youths but Has Lower Predictive Utility Compared With Non-Genetic Factors
Authors: Miranda-Lora América Liliana , Vilchis-Gil Jenny , Juárez-Comboni Daniel B. , Cruz Miguel , Klünder-Klünder Miguel 
Published: March 2021

BackgroundType 2 diabetes (T2D) is a multifactorial disease caused by a complex interplay between environmental risk factors and genetic predisposition. To date, a total of 10 single nucleotide polymorphism (SNPs) have been associated with pediatric-onset T2D in Mexicans, with a small individual effect size. A genetic risk score (GRS) that combines these SNPs could serve as a predictor of the risk for pediatric-onset T2D.ObjectiveTo assess the clinical utility of a GRS that combines 10 SNPs to improve risk prediction of pediatric-onset T2D in Mexicans.MethodsThis case-control study included 97 individuals with pediatric-onset T2D and 84 controls below 18 years old without T2D. Information regarding family history of T2D, demographics, perinatal risk factors, anthropometric measurements, biochemical variables, lifestyle, and fitness scores were then obtained. Moreover, 10 single nucleotide polymorphisms (SNPs) previously associated with pediatric-onset T2D in Mexicans were genotyped. The GRS was calculated by summing the 10 risk alleles. Pediatric-onset T2D risk variance was assessed using multivariable logistic regression models and the area under the receiver operating characteristic curve (AUC).ResultsThe body mass index Z-score (Z-BMI) [odds ratio (OR) = 1.7; p = 0.009] and maternal history of T2D (OR = 7.1; p &lt; 0.001) were found to be independently associated with pediatric-onset T2D. No association with other clinical risk factors was observed. The GRS also showed a significant association with pediatric-onset T2D (OR = 1.3 per risk allele; p = 0.006). The GRS, clinical risk factors, and GRS plus clinical risk factors had an AUC of 0.66 (95% CI 0.56–0.75), 0.72 (95% CI 0.62–0.81), and 0.78 (95% CI 0.70–0.87), respectively (p &lt; 0.01).ConclusionThe GRS based on 10 SNPs was associated with pediatric-onset T2D in Mexicans and improved its prediction with modest significance. However, clinical factors, such the Z-BMI and family history of T2D, continue to have the highest predictive utility in this population.
Association Between a Tri-allelic Polymorphism in the Estrogen Metabolism Oxidoreductase NRH:Quinone Oxidoreductase 2 Gene and Risk of Breast Cancer by Molecular Subtype
Authors: Zhou Jiao-Qun , Zhu Si-Yuan , He Ye , Yu Ke-Da 
Published: March 2021

Background: We hypothesized that NRH:quinone oxidoreductase 2 (NQO2) is a candidate susceptibility gene for breast cancer because of its known enzymatic activity on estrogen-derived quinones. A tri-allelic polymorphism in the NQO2 gene might be associated with the risk of luminal-like breast cancer.Methods: In this case-control study, 2,865 women were recruited, including 1,164 patients with pathologically confirmed breast cancer and 1,701 cancer-free controls. The tri-allelic genetic polymorphism (I-29, I-16, and D alleles) was genotyped by a polymerase chain reaction and restriction fragment length polymorphism (RFLP)-based assay. Because the I-16 allele frequency is rare (approximately 1.0%), individuals carrying the I-16 allele were excluded from the analysis. Breast cancer subtypes were classified according to ER, PR, HER2, and grade.Results: In the association analysis of allele, an increased risk of breast cancer is associated with I-29 allele [82.5% in case group and 79.0% in the control group; odds ratio (OR), 1.25; 95% CI, 1.09–1.43, compared with D allele, p = 0.0015]. In the association analysis of genotype, the I-29-containing genotype was significantly correlated with breast cancer under a dominant model (adjusted OR, 1.31, 95% CI, 1.12–1.54, p = 0.001). Moreover, in the subtype analysis, there was a significant association of the I-29/D polymorphism with luminal-like breast cancer (adjusted OR, 1.54, 95% CI, 1.22–1.94, p = 0.001 for luminal-A disease; adjusted OR, 1.37, 95% CI, 1.06–1.76, p = 0.014 for luminal-B disease) but not with HER2-enriched or triple-negative subtypes.Conclusion: The tri-allelic polymorphism in the NQO2 gene is associated with breast cancer risk, especially for the luminal-like subtype. Our findings provide a new piece of molecular epidemical evidence supporting the hypothesis that estrogen and its metabolites are carcinogens of luminal-like breast cancer. Further external validation studies are needed.