bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corporate Social Responsibility (CSR) Efficiency Approach with the Establishment of a State Institution Managing Funding and CSR Programs
Authors: Soetrisno Agustinus 
Published: November 2021

<p>CSR is an activity that provides broader benefits in various social aspects such as education, health, community empowerment or environmental preservation. CSR actions applied as a strategy will only cause irregularities in the use of funds owned by the company which can trigger to damage to the company's financial performance. This is thought to be due to the fact that there are quite a lot of funds budgeted with the CSR implementation which is not supervised, which causes inefficiency. This study aims to determine and analyze the provisions of the laws and regulations that govern CSR related to the obligations of Limited Liability Companies in the Indonesian legal system and to find out and analyze the implementation of company obligations to implement CSR in Indonesia and find solutions to corporate liability arrangements such as Limited Liability Companies (PT), Enterprises. Micro, Small and Medium Enterprises (UMKM) and other businesses carry out CSR to be useful in accordance with that CSR. The approach used is the Legislative Law approach and the case approach. From the research results it is known that 1). CSR regulations concerning the obligation of PT to implement it in the Indonesian legal framework are regulated in several laws but there are 2 (two) laws that specifically regulate CSR but the two laws are inconsistent with regard to sanctions if these obligations are violated, 2) Implementation of PT obligations implementing CSR in Indonesia is a program carried out by the company that is not in accordance with the community needs, is carried out individually, is moving and it’s not sustainable, there is no provision that regulates the amount of funds and there is no supervision from the local government in managing CSR. The occurrence of overlapping laws and regulations so that the implementation of the CSR program does not match the policies issued by the local government. CSR funds are misused and even corrupted by local officials and there is no evaluation by the company because it is more concerned with profit in carrying out CSR. 3). Regulating company obligations such as Limited Liability Companies (PT), Micro, Small and Medium Enterprises (MSMEs) and other businesses implementing CSR so that it is useful, it is necessary to establish a state institution that manages CSR and accommodates the companies’, government’s and society interests so that the CSR program can run efficiently, precisely targeted and continuously.</p><p> </p>
Notary Malpractice in Carrying Out Their Duties and Authorities
Authors: Wiryomartani Winanto 
Published: November 2021

<p>As an official whose duty and authority is making authentic deeds, a Notary is responsible for all the content of the deed he/ she made and all the information relating to the deed made before/ by him/ her, based on the Official Oath of the Notary and Notary Law. Notary is a noble position (<em>noblese obligue</em>), and Notaries are expected to keep their dignity as official. The consequences of such honorable position and authority of Notary is that Notaries are obliged to do everything that is regulated in the Notary Law and obey everything that is prohibited by the law, regulations, and the Notary’s Code of Ethics, in carrying out both their duties and authority, Notaries are responsible for any consequences arises from any violation of the position of a Notary. For any malpractice committed by a Notary, a Notary may be held liable to civil and criminal lawsuits. This article explains about: (1) The law and regulations applied to Notary in Indonesia in carrying out their duties and authorities. (2) How does the Notary practice in Indonesia in carrying out their duties and authorities. (3) How the ideal Law and Regulations should be applied to Notary, so that Notary malpractice can be eliminated, or at least reduced, and Notaries can carry out their duties and authorities as they are mandated. </p>
Variation in the Profit Margin for Different Types of Total Joint Arthroplasty
Authors: Fang Christopher J. , Shaker Jonathan M. , Hart Paul-Anthony , Cassidy Charles , Mattingly David A. , Jawa Andrew , Smith Eric L. 
Published: November 2021

Background:
As health care shifts to a value-based model with bundled-payment methods, it is important to understand the costs and reimbursements of arthroplasty procedures that represent the largest expenditure of Medicare. The aim of the present study was to characterize the variation in (1) total hospital costs, (2) reimbursement, and (3) profit margin for different arthroplasty procedures.

Methods:
The total hospital costs of total knee arthroplasty (TKA), total hip arthroplasty (THA), anatomic total shoulder arthroplasty (TSA), reverse shoulder arthroplasty (RSA), and total ankle arthroplasty (TAA) were calculated with use of time-driven activity-based costing at an orthopaedic institution from 2018 to 2020. The average reimbursement for each type of procedure was determined. Profit margin, defined as the reimbursement profit after direct costs, was calculated by deducting the average time-drive activity-based total hospital costs from the reimbursement value. Multivariate analyses were performed to evaluate the associations between costs, reimbursement, and profit margins.

Results:
There were 13,545 arthroplasty procedures analyzed for this study, including 6,636 TKAs, 5,902 THAs, 346 TSAs, 577 RSAs, and 84 TAAs. Costs and reimbursement were highest for TAA. THA and TKA resulted in the highest profit margins, whereas RSA resulted in the lowest. The strongest associations with profit margin were private insurance (0.46547), age (−0.22732), and implant cost (−0.19240).

Conclusions:
THA and TKA had greater profit margins overall than TAA and upper-extremity arthroplasty in general. Profit margins for RSA, TSA, and TAA were all at least 28% lower than those for TKA or THA. Lower-volume arthroplasty procedures were associated with decreased profit margins. Study findings suggest that optimizing implant costs and length of stay are important for sustaining institutional fiscal health when performing shoulder and ankle arthroplasty surgery.
Rare Case of Dynamic Thoracic Outlet Syndrome Resolved by an Isolated Subclavius Posticus Muscle Resection
Authors: Dukan Ruben , Petroni Gautier , Muller Guy-Paul , Silvera Jonathan , Masmejean Emmanuel H. 
Published: November 2021

Case:
We reported a dynamic neurogenic left thoracic outlet syndrome (TOS) with a permanent abduction of the fifth left finger. Preoperative magnetic resonance imaging (MRI) assessed the presence of subclavius posticus muscle (SPM). Because of a nonoperative treatment failure, we performed a brachial plexus neurolysis and SPM resection. Immediate postoperative assessment showed an immediate disappearance of the Wartenberg sign.

Conclusion:
SPM constitutes an underestimated cause of TOS. A careful MRI reading is necessary to make correct diagnosis. Nonoperative treatment includes physiotherapy and can be proposed in first instance. When nonoperative treatment fails, brachial plexus exploration with release of the SPM may result in resolution of symptoms.
Long-Term Stability of PVDF-SiO2-HDTMS Composite Hollow Fiber Membrane For Carbon Dioxide Absorption in Gas–Liquid Contacting Process
Authors: Pang Honglei , Qiu Yayu , Sheng Weipeng 
Published: November 2021

Abstract
To obtain a long-term stable operation of the hollow fiber membrane for using in membrane contact absorption of carbon dioxide (CO2), hybrid polyvinylidene fluoride-silica-hexadecyltrimethoxysilane (PVDF-SiO2-HDTMS) membrane were fabricated via the non-solvent induced phase-inversion method. The surface properties, performance characteristics and long-term stable operation performance of the prepared membranes were compared and analyzed. The results show the outer surface of the prepared membranes exhibited superhydrophobicity because of the formation of rough nano-scale microstructures and the low surface free energy. Due to the addition of inorganic nanoparticles, the mechanical strength of PVDF-SiO2-HDTMS membranes were improved. The long-term stable operation experiments were carried out with the inlet gas (CO2/N2 = 19/81, v/v) at a flow rate of 20 mL/min and the absorbent liquid (1 mol/L DEA) at a flow rate of 50 mL/min. And the result showed that the mass transfer flux of PVDF-SiO2-HDTMS membrane decreased from the initial value of 2.39×10-3 mol/m2s to 2.31×10-3 mol/m2s, which was a decrease of 3% after 20 days. The main benefit is the addition of inorganic nanoparticles, which have strong chemical resistance and high hydrophobicity, thereby preventing structural damage and pore wetting of the membrane. PVDF-SiO2-HDTMS membrane exhibits excellent long-term stable operation performance of CO2.
The Complete Chloroplast Genome of Critically Endangered Chimonobambusa hirtinoda (Poaceae: Chimonobambusa) and Phylogenetic Analysis
Authors: liu yanjiang , Zhu Xiao , Wu Mingli , Xu Xue , Dai Zhaoxia , Gou Guangqian 
Published: November 2021

Abstract
Chimonobambusa hirtinoda is a threatened species and only naturally distributed in Doupeng Mountain, Duyun, Guizhou, China. Next-generation sequencing (NGS) is used obtained the complete chloroplast (cp) genome sequence of C. hirtinoda, and then the sequence was assembled and analyze for phylogenetic and evolutionary. We also analyzed comparing the cp genome among Chimonobambusa species with previously published. The complete cp genome of C. hirtinoda has the total length of 139, 561 bp, 38.90% GC content was detected. A total of 130 genes were founded in the cp genome, including 85 protein coding genes, 37 tRNA genes, 8 rRNA. Some genes are missing and the introns occur lost in the cp genome of C. hirtinoda. A total of 48 simple sequence repeat (SSR) were detected and by measuring the codon usage frequency of amino acids, the A/U preference of the third nucleotide in the cp genome of C. hirtinoda was obtained. Furthermore, phylogenetic analysis using complete cp sequences, matk gene exhibited genetic relationship within the Chimonobambusa genus.
Understanding the Role of Student Stress, Personality and Coping on Learning Motivation and Mental Health During a Pandemic
Authors: Gibbons Chris 
Published: November 2021

Abstract
The aims explored associations between stress ratings and influences on coping on student mental health and motivation and compared defensive-pessimism against optimism as a strategy for learning motivation. Most research construes stress as distress, with little attempt to consider positive ‘eustress’ experiences. Undergraduate psychology students (N=162) were surveyed on student and pandemic-related stressors, personality, support, control, mental health and learning motivation. Overall, lack of motivation and procrastination were acute. Uplifting ratings of teaching and optimistic thinking were associated with good mental health, but context control was key. Hassle ratings of teaching lowered learning motivation. Support and conscientiousness bolstered learning motivation, with the latter an important buffer against hassle experiences on motivation. Openness was associated with the stress involved in learning. For those anxious-prone, defensive-pessimism was as effective as optimism was for those not anxious-prone, in stimulating learning motivation. Developing context control, support and strategies linked to personality could bolster student resilience during and post Covid-19.
Efficacy and Safety of Vedolizumab for Pediatrics With Inflammatory Bowel Disease: a Systematic Review
Authors: Fang Shengbo , Song Yanqing , Zhang Chunyan , Wang Libo 
Published: November 2021

Abstract
Background: Vedolizumab use in pediatrics is still off-label and the data are limited. We conducted a systematic review evaluating the efficacy and safety of vedolizumab in children and adolescents with inflammatory bowel disease (IBD). Methods: PubMed, EMBASE and Cochrane databases were systematically searched for studies of vedolizumab in children and adolescents with IBD reporting clinical remission, response, corticosteroid-free (CS-free) remission, mucosal healing, or safety up to November 21 2020. Results: 7 studies, comprising 238 patients were included. For CD, the pooled clinical remission rates were 25% (19/75) at 6 weeks, 28% (19/67) at 14 weeks, 32% (17/53) at 22 weeks, and 25% (1/4) at 1 year. For UC/IBD-U, the pooled clinical remission rates were 36% (25/70) at 6 weeks, 52% (32/61) at 14 weeks, 53% (24/45) at 22 weeks, and 60% (6/10) at 1 year. Mucosal healing was found in 17%-39% of CD and 15%-34% of UC/IBD-U respectively. Six percent of patients reported serious adverse events.Conclusions: According to low-quality evidence based on case series, approximately one-third and one-half of patients for CD and UC/IBD-U respectively achieved remission within 22 weeks. Long-term benefit profile data and high quality evidence are still needed.
MiR-21 is a Predictor for Chemoradioresistance and a Novel Therapeutic Target in Head and Neck Squamous Cell Carcinoma
Authors: Ishinaga Hajime , Okugawa Yoshinaga , Hou Bo , He Feng , Yin Chengzeng , Shah Said Ahmad , Murata Mariko , Toiyama Yuji , Takeuchi Kazuhiko 
Published: November 2021

Abstract
ObjectiveThis study aimed to clarify whether circulating miR-21 represents a predictive biomarker in patients with head and neck squamous cell carcinoma (HNSCC) undergoing chemoradiotherapy, and to investigate the effect of miR-21 inhibitor for chemoradiation in human SCC cells.MethodsPlasma samples were obtained from 22 patients with HNSCC and 25 non-cancer volunteers. Plasma miR-21 expression was measured using real-time quantitative reverse transcription polymerase chain reaction. The effects of miR-21 inhibitor in human SCC cells were investigated by performing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, flow cytometry, and Western blot analysis.ResultsPlasma miR-21 expression was higher in HNSCC patients than in control patients (p< 0.001). Seven patients with recurrence showed significantly higher plasma miR-21 than the 15 patients without recurrence. Moreover, miR-21 inhibition significantly enhanced cisplatin- or radiation-induced apoptosis. Western blot analysis suggested the programmed cell death 4 (PDCD4) protein as a potential target of miR-21 in relation to apoptosis. Adding miR-21 inhibition to radiation or cisplatin treatment provided clear and potent suppression of tumor cell proliferation.ConclusionThis study provides new insights into the role of miR-21 as a predictive biomarker for HNSCC treated with chemoradiotherapy, and suggests a potential target to improve the effects of chemoradiotherapy against HNSCC.
Selection of CMIP6 GCM With Projection of Climate Over The Amu Darya River Basin
Authors: Salehie Obaidullah , Hamed Mohammed Magdy , Ismail Tarmizi , Tam Tze Huey , Shahid Shamsuddin 
Published: November 2021

Abstract
Global Climate Models (GCMs) are considered the most feasible tools to estimate future climate change. The objective of this study was to assess the interpretation of 19 GCMs of Coupled Model Intercomparison Project 6 (CMIP6) in replicating the historical precipitation and temperature of climate prediction center data for the Amu Darya river basin (ADRB) and the projection of climate of the basin using the selected GCMs. The Kling Gupta efﬁciency (KGE) metric was used to assess the effectiveness of GCMs to simulate the annual geographic variability of precipitation, maximum and minimum temperature (Pr, Tmx and Tmn). A multi-criteria decision-making approach (MCDMA) was used to integrate the KGE values to rank GCMs. The results revealed that MPI-ESM1-2-LR, CMCC-ESM2, INM-CM4-8 and AWI-CM-1-1-MR are the best in replicating observed Pr, Tmx and Tmn in ADRB. Projection of climate employing the selected GCMs indicated an increase in precipitation (9.9-12.4%) and temperature (1.3-5.5⁰C) in the basin for all the shared socioeconomic pathways (SSPs), particularly for the far future (2060-2099). A significant variation can be seen in temperature over the different climatic zone. However, the intercomparison of selected GCM projected revealed high uncertainty in the projected climate. The uncertainty is higher in the far future and higher SSPs compared to the near future and lower SSPs.
Xylanase Production By Thermobacillus Xylanilyticus is Impaired By Population Diversification But Can Be Mitigated Based On the Management of Cheating Behavior
Authors: Bouchat Romain , Vélard Frédéric , Audonnet Sandrine , Rioult Damien , Delvigne Frank , Rémond Caroline , Rakotoarivonina Harivony 
Published: November 2021

Abstract
Background: The microbial production of hemicellulasic cocktails is still a challenge for the sector of biorefineries and agro-waste valorization. In this work, the production of hemicellulolytic enzymes by Thermobacillus xylanilyticus has been considered. This microorganism is of interest since it is able to produce an original set of thermostable hemicellulolytic enzymes, and notably a xylanase GH11, Tx-xyn11. However, cell-to-cell heterogeneities impairs the production capability of the whole microbial population.Results: Sequential cultivations of the strain on xylan as a carbon source has been considered in order to highlight and better understand this cell-to-cell heterogeneity. Successive cultivations pointed out a fast decrease of xylanase activity (loss of ~75%) after 23.5 generations. Accordingly, the expression of the Tx-xyn11 gene decreased drastically and followed the same trend as the xylanase activity. Flow cytometry analyses pointed out that two subpopulations, differing at the level of their light scattering properties, were potentially involved in this progressive loss of enzymatic activities. Interestingly, upon successive cultivations on xylan, the subpopulation exhibiting low forward scatter (FSC) signal. Additionally, the evolution of the ratio between the two subpopulations was correlated to the decrease in xylanase activity. Cell sorting and direct observation of the sorted subpopulations revealed that the low-FSC subpopulation was not sporulating, whereas the high-FSC subpopulation contained cells at the onset of the sporulation stage. Serial cultivations on glucose, followed by the addition of a xylan pulse led to a ~1.5-fold to ~15-fold improvement of xylanase, depending on the moment for pulse addition, , suggesting that alternating cultivation conditions could lead to an efficient population management strategy for the production of xylanase. Conclusions: Taken altogether, the data from this study point out that a cheating behaviour is responsible for the progressive reduction in xylanase activity during serial cultivations of T. xylanilyticus. Alternating cultivation condition between glucose and xylan could be used as an efficient strategy for promoting population stability and higher enzymatic productivity from this bacterium.
Preoperative Sarcopenia is Associated with Poorer Compliance Rate of Adjuvant Chemotherapy and Worse Disease-free Survival of Patients with Stage Ⅲ Colon Cancer
Authors: Yu Liang , Chen Guangliang , Xu Zongbin , Chi Pan , Chen Zhifen 
Published: November 2021

Abstract
Purpose: Preoperative sarcopenia has been proved to be associated with worse postoperative outcomes in cancer patients. This study aimed to evaluate whether preoperative sarcopenia affects the perioperative outcomes, adjuvant chemotherapy, and long-term outcomes of patients with stage Ⅲ colon cancer.Methods: Total 218 patients who underwent curative resection for stage Ⅲ colon cancer in our department from January, 2015 and December, 2018 were retrospectively analyzed. Sarcopenia was assessed by total psoas index, which measured the total area the level of L3 vertebral body and normalized according to patients’ height. Perioperative complications, postoperative adjuvant chemotherapy, and long-term prognosis were retrospectively analyzed.Results: Of 218 patients, 100(45.9%) patients were diagnosed with sarcopenia. Sarcopenia did not add the risk of perioperative complications (20.0% vs 15.3%, P=0.357), but it increased hospital stays (7.6±3.9 vs 6.7±2.2 days, P=0.042). Patients with sarcopenia had a lower rate of receiving adjuvant chemotherapy (70.0% vs 82.2%, p=0.033) and less likely to receive adequate adjuvant chemotherapy (58.6% vs 70.1, P=0.08). Patients with adequate adjuvant chemotherapy had significantly better 3-year OS (89.8% vs 79.5, P=0.005) and a tendency of better 3-year DFS (76.4% vs 63.6%, P=0.055) than those with inadequate adjuvant chemotherapy and Non-adjuvant chemotherapy. Compared with the patients without sarcopenia, patients with sarcopenia had significantly worse 3-year DFS (76.9% vs 62.8%, P=0.026).Conclusion: Preoperative sarcopenia was an important indicator to predict the compliance of AC in stage Ⅲ colon cancer patients, and it is also a significant prognostic factor of worse 3-year DFS.
Comparison of Clinical Characteristics and Ultrasound Features of Ovarian Clear Cell Carcinoma and Ovarian High-Grade Serous Carcinoma
Authors: Liu Wei , Qian Lin-Xue , wei Xue-Jing 
Published: November 2021

Abstract
Purpose To investigate clinical and ultrasound features for differentiating ovarian clear cell carcinoma (OCCC) from ovarian high-grade serous carcinoma (HGSC). Methods Forty-five patients with OCCC and 72 patients with HGSC were retrospectively studied. Patient clinical characteristics and ultrasound features of tumors were evaluated. The differences, including laterality, menopausal status, Federation of Gynecology and Obstetrics (FIGO) stage between OCCC and HGSC patients were compared by Fisher’s exact test. The ultrasound features of tumors, including laterality, shape, configuration, color score, peritoneal implantation, and ascites, were evaluated and compared between the two groups. Results The average age at diagnosis in the OCCC group was 57.6±11.1 (range, 30–76) years, and 35.56% of patients were premenopausal. However, the average age at diagnosis was 63.4±12.2 (range, 42-81) years and 33.33% of patients were premenopausal in the HGSC group. There was a statistically significant difference in unilaterality (P< 0.001), clear boundaries (P<0.05), round or oval shape (P <0.05), and color score (P<0.05). Compared to HGSC patients, fewer OCCC patients had peritoneal implantation and ascites. There was a statistically significant difference in the mean size of papillary projections in OCCC and HGSC (P<0.05). The mean size of the papillary projections was significantly larger in OCCC than in HGSC. Conclusions OCCC commonly appeared as a large, round or oval mass with a clear boundary; the papillary projections of OCCC are larger and round. In contrast, HGSC was typically a large, irregular tumor with solid masses or mixed cystic-solid masses with small papillary projections.