bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of plasma homocysteine on cardiometabolic multimorbidity among Chinese adults: a population-based and real-world evidence study
Authors: Li Ling , Wang Jia , Li Jing , Li Minqi , Wang Jie , Long Tianyao , Zhengliu Yangyi , Tan Xuan , Peng Yiwei , Hong Xiuqin 
Published: December 2024

AimsTo explore the effect of plasma homocysteine (Hcy) on cardiometabolic multimorbidity (CMM) among Chinses adults.MethodsThis study combined a community-based cross-sectional study with a 1:1 matched case–control study using propensity score method among adults aged over 30 years in six districts randomly selected from Hunan Province, China. We recruited 5,258 people, of whom 4,012 met the study criteria were enrolled. CMM was defined as the coexistence of two or more cardiometabolic diseases, including diabetes, hypertension, coronary heart disease and stroke. The plasma Hcy and other laboratory data was measured by chemical automatic detector. Lifestyles and personal characteristics were collected by a questionnaire. Multivariate models were used to explore the associations. We calculated the attributable risk proportion (ARP) for the association of Hcy with CMM. The dose–response relationship was evaluated using restricted cubic splines method.ResultsOf the 4,012 adults, 436 had CMM, with a population prevalence of 10.9%. In the propensity-score-matched case–control study, 828 (414 cases and 414 controls) were included, and those with high plasma Hcy level (&gt;16.2 μmol/L) had a higher risk of CMM than those with lowest level (&lt;10.4 μmol/L) (adjusted OR = 2.83, 95% CI: 1.84–4.36, p &lt; 0.001), with a multivariate ARP of high level of exposure was 64.66% (95% CI: 46.24–77.06%). The largest effect combination of CMM was the coexisting of diabetes, hypertension and coronary heart disease (adjusted OR = 2.26, 95%CI: 1.43–3.57, p &lt; 0.001). An inverse association and dose–response relationship were observed between CMM and plasma Hcy levels. Notably, we recognized a significant mediation effect by C-reactive protein, total cholesterol, triglyceride and waist circumference, and they mediated approximately 8 ~ 23% of the effect of Hcy on risk of CMM.ConclusionOur findings add new evidence to this field that of high level of plasma Hcy was consistently associated with higher risk of CMM among Chinses adults, with the largest effect combination of being coexisting diabetes, hypertension and coronary heart disease. These findings have implications for cardiologists that CMM can be attributable to high level of plasma Hcy, and for decision makers that Hcy has become a public threat that persistently affects cardiovascular health in humans.
Case report: Treatment of a rare primary cerebellum histiocytic sarcoma with surgery and radiotherapy
Authors: Yanchu Li , Li Zhang , Qiongwen Zhang , Jiayu Duan , Feng Wang 
Published: December 2024

BackgroundHistiocytic sarcoma originates in various tissues, including the skin, lymph nodes, gastrointestinal tract, lungs, bone marrow, and central nervous system. Primary central nervous system histiocytic sarcoma (PCNSHS) is exceptionally rare, known for its aggressive behavior and poor prognosis. This report describes a case of PCNSHS in the cerebellum treated with surgery and radiotherapy.Case presentationA 30-year-old woman presented with progressive dizziness and headache. Magnetic resonance imaging scans showed right cerebellar neoplastic lesions approximately 3.6 cm*3.0 cm with cerebral edema and fourth ventricle and brainstem compression. The patient underwent surgical debulking, and the pathological diagnosis was PCNSHS. Two months after the surgery, the patient underwent adjuvant radiotherapy at a dose of 60 Gy. No tumor progression has been observed during the one-year follow-up period.ConclusionsThis case report provides an example of effective central nervous system control using resection and radiation therapy. A review of the literature confirms that surgery alone or combined concurrent or sequential treatment of radiotherapy and chemotherapy is often used; however, the best treatment plan remains unclear. Moreover, the prognosis is poor, with a median survival of six months. Thus, ongoing research aims to better understand the biology of histiocytic sarcomas and find more effective strategies.
An MRI-based radiomics nomogram for preoperative prediction of Ki-67 index in nasopharyngeal carcinoma: a two-center study
Authors: Wang Yao , Zhang Jing , Li Qiyuan , Sun Li , Zheng Yingmei , Gao Chuanping , Dong Cheng 
Published: December 2024

BackgroundThe expression level of Ki-67 in nasopharyngeal carcinoma (NPC) affects the prognosis and treatment options of patients. Our study developed and validated an MRI-based radiomics nomogram for preoperative evaluation of Ki-67 expression levels in nasopharyngeal carcinoma (NPC).MethodsIn all, 133 patients with pathologically-confirmed (post-operatively) NPC who underwent MRI examination in one of two medical centers. Data from one medical center (n=105; Ki-67: ≥50% [n=57], &lt;50% [n=48]) formed the training set, while data from another medical center (n=28; Ki-67: ≥50% [n=15], &lt;50% [n=13]) formed the test set. Clinical data and routine MRI results were reviewed to determine significant predictive factors. The minimum absolute shrinkage and selection operator method was used to select key radiomics features to form a radiomics signatures from resonance imaging (MRI), and a radiomics score (Rad-score) was calculated. Subsequently, a radiomics nomogram was established using a logistic regression (LR) algorithm. The predictive performance of the nomogram was evaluated using operating characteristics curve (ROC), decision curve analysis (DCA), and the area under the curve (AUC).ResultsFive radiomics features were selected to build the radiomics signature. The radiomics nomogram incorporating the clinical factors and radiomics signature showed favorable predictive value for expression level of Ki-67, with AUC 0.841 (95% confidence intervals: 0.654 –0.951) for the test set. Decision curve analysis showed that the nomogram outperformed a clinical model in terms of clinical usefulness.ConclusionsThe radiomics nomogram based on MRI effectively predicted the pre-surgical expression level of Ki-67.
Configuring thermal ablation volumes for treatment of distinct tumor shapes: a repeatability study using a robotic approach
Authors: Bulatović Milica , Hermann Jan , Tinguely Pascale , Paolucci Iwan , Weber Stefan 
Published: December 2024

ObjectivesIn the current clinical practice of thermal ablation treatment for liver tumors, achieving consistent and effective clinical outcomes across tumors of varying shapes, sizes and locations remains challenging. The aim of this study was to evaluate the repeatability of a novel robotic approach for configurable ablation of distinct tumor shapes and compare it to the standard ablation technique for creating ellipsoidal ablation volumes.Materials and methodsThe repeatability was evaluated in terms of width variability in created ablation volumes. Using a robotic navigation platform, custom ablation profiles configured with power, time, and distance parameters were designed to create four distinct ablation shapes. The profiles were applied for microwave ablation in a tissue-mimicking liver model. For comparison of ablation shape variability, six standard ellipsoidal shapes were created using the standard ablation technique by configuring power and time parameters. For each sample, the resulting ablation area was segmented, and the resulting shape width and length were calculated at the measurement points. Width variability was calculated as the median of the absolute pairwise differences in width at each measurement point, and configurable versus standard ablation shapes were compared using the Mann–Whitney U test.ResultsAll tissue-mimicking samples were successfully ablated using both configurable (n = 48) and standard ablation technique (n = 35). Study findings revealed noninferiority regarding repeatability of created ablation shapes using the robotic platform for configurable ablation, compared to created standard ellipsoidal ablation shapes (p &lt; 0.001, 95% CI ≤ -0.05 mm, Δ = -0.22 mm). Median repeatability of created configurable shapes was 1.00 mm, and for standard shapes 1.22 mm. Maximal repeatability for both groups was below 3 mm.ConclusionThe repeatability of configurable ablation shapes was observed to be noninferior to the standard ablation shapes. Achieving configurable ablation volumes underscores the potential to advance personalization of thermal ablation treatment and broaden its applicability to distinct tumor cases. In-vivo validation is needed for evaluation of the clinical implications of this novel treatment technique.
Determinants of quality of life following resection of skull base tumors: a systematic review
Authors: Sperl Veronika , Rhomberg Thomas , Kretschmer Thomas 
Published: December 2024

BackgroundSkull base tumors represent a small subset of intracranial neoplasm. Due to their proximity to critical neurovascular structures, their resection often leads to morbidity. As a result, surgical interventions can exacerbate symptoms or cause new deficits, thereby impacting the patients’ perceived quality of life (QoL). The factors influencing QoL in patients with skull base tumors remain underexplored. This systematic review aims to synthesize current research on QoL outcomes and identify potential factors influencing QoL in these patients.MethodsA systematic literature review was conducted in PubMed using the keywords “Skull Base” AND “Quality of Life.” A total of 815 studies published up to January 31, 2024, were screened. After abstract review, 656 studies were excluded, and 159 studies underwent full-text review. The wide variability in study methodologies and utilized QoL instruments made only a descriptive comparison possible.ResultsIn total, 113 studies were systematically reviewed. Publications focusing on the same tumor type or localization were compared. The majority of studies addressed tumors of the anterior skull base, with pituitary adenomas, meningiomas and vestibular schwannomas being the most commonly represented. The impact of surgery on QoL is often underestimated by caregivers and has a more profound effect on patients than expected by surgeons. A transient decline in QoL after surgery was observed across almost all studies regardless of localization and entity. Factors influencing QoL included age, gender, tumor localization, surgical approach, tumor type, extent of resection, preoperative clinical status and neurological deficits. Radiotherapy and recurrent surgeries were predictors of poorer QoL. Early psychological intervention in complex tumors appears to enhance QoL. Some successful sealing techniques, such as nasoseptal flaps and lumbar drains, affected QoL. However, variability in study methodologies reduced the validity of the findings.ConclusionThis review highlights the significant impact of skull base tumor surgery on patients’ QoL. Given the major oncological and surgical challenges presented by skull base tumors, their treatment significantly affects QoL, and gross total resection (GTR) should not always be the primary goal. Additionally, recognizing and addressing the modifiable and non-modifiable factors influencing QoL is crucial for improving patient outcomes and providing personalized care.
Incidence and risk factors for acute kidney injury in children with nephrotic syndrome: a meta-analysis
Authors: Chen Changdi , Qiu Bingbing , Wang Jianxin , Yang Liuqing , Huang Yanru 
Published: December 2024

BackgroundNephrotic syndrome (NS) is a prevalent kidney disease in children. Acute kidney injury (AKI) is a severe complication of NS and has the potential to be life-threatening.ObjectiveThe aim of this study was to analyze the prevalence and risk factors of AKI in children with NS, and to provide an evidence-based medical basis for the early identification of high-risk children in the clinic.MethodsA comprehensive search was conducted in publicly available databases, namely PubMed, Embase, Web of Science, Scopus, and the Cochrane Library, covering the period from the inception of each database until May 2024. The analysis involved examining basic characteristics (age, sex), the concomitant diseases (hypertension, infections), NS disease characteristics (steroid susceptibility classification, pathologic classification), laboratory test (e.g., serum albumin), and the use of nephrotoxic drugs. Traditional and network meta-analyses were performed for analysis.ResultsA total of 11 studies were included in the analysis, revealing an incidence of AKI of 29% (95% CI: 23%–37%). The analysis of factors indicated that the age of NS onset [standardized mean difference (SMD): 0.31; 95% confidence interval (CI): 0.08, 0.54; p = 0.009], sex [odds ratio (OR): 1.49; 95% CI: 1.03, 2.16; p = 0.035], serum albumin level (SMD: −0.43; 95% CI: −0.85, −0.02; p = 0.041), response to steroid treatment (OR: 0.52; 95% CI: 0.33, 0.80; p = 0.003), infection (OR: 3.60; 95% CI: 1.91, 6.78; p &lt; 0.001), hypertension (OR: 4.02; 95% CI: 2.94, 5.51; p &lt; 0.001), and nephrotoxic drug application (OR: 4.43; 95% CI: 1.86, 10.53; p = 0.001), were all significantly associated with the incidence of AKI. Furthermore, the results of the network meta-analysis suggested that the pathologic type of minor glomerular abnormalities (MGA)/diffuse mesangial proliferation (DMP), the type of infrequent relapses (IFRNS)/steroid-sensitive NS (SSNS), and the use of diuretic medications were associated with a relatively low risk of AKI occurrence.ConclusionFactors upon admission of children with NS are associated with the onset of AKI. Emphasis should be placed on populations with a heightened risk of AKI in clinical practice. Further research is warranted to confirm the findings due to the limitations of this study.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024571170, PROSPERO (CRD42024571170).
The endocannabinoid anandamide prevents TH17 programming of activated T lymphocytes while preserving TH1 responses
Authors: Kiprina Anastasiia , Teichmann Tom , Martín Giménez Virna Margarita , Xu Wenqing , Sailer Fiona , Windbergs Maike , Manucha Walter , Weigert Andreas , Brandes Ralf P. 
Published: December 2024

IntroductionAnandamide (AEA) is an endocannabinoid that has recently been recognized as a regulator of various inflammatory diseases as well as cancer. While AEA was thought to predominantly engage cannabinoid (CB) receptors, recent findings suggest that, given its protective anti-inflammatory role in pathological conditions, anandamide may engage not only CB receptors.MethodsIn this study, we studied the role of exogenous AEA in a mouse AirPouch model of acute inflammation by examining immune cell infiltrates by flow cytometry. Human primary immune cells were used to validate findings towards immune cell activation and migration by flow cytometry and bead-based ELISA.ResultsWe found that AEA decreases the acute infiltration of myeloid cells including granulocytes and monocytes into the inflamed area, but unexpectedly increases the number of T cells at the site of inflammation. This was related to AEA signaling through nuclear receptor subfamily 4A (NR4A) transcription factors rather than CB receptors. Exploring regulatory mechanisms in the human system, we found that AEA broadly inhibits the migratory capacity of immune cells, arguing for blocked emigration of T cells from the inflamed tissue. Taking a closer look at the impact of AEA on T cells revealed that AEA profoundly alters the activation and exhaustion status of CD4+ T and CD8+ T cells, thereby strongly inhibiting TH17 responses, while not altering TH1 differentiation.DiscussionThese data suggest that AEA has the potential to block chronic inflammation without influencing crucial anti-viral and anti-microbial immune defense mechanisms, and may therefore be an attractive molecule to interfere with the establishment of chronic inflammation.
The effects of interactive video games combined with LEGO game therapy on social anxiety in rural left-behind children
Authors: Peng Dianhui , Wu Xinbo , Yang Yaqi , Li Xiaolin , Shu Anni , Liang Junwen , Tu Zengying , Liu Le , Yang Qian , Dong Weixin , Lu Chunxia 
Published: December 2024

BackgroundChina has a significant population of left-behind children, defined as those whose parents have migrated away from their home for at least six months. This situation arises when one or both parents leave to seek work in urban areas. Among the various challenges faced by left-behind children, social anxiety has emerged as one of the most pressing issues.ObjectiveThis study aims to deeply explore the impact of interactive video games and LEGO games on the social anxiety of rural left-behind children, with the aim of providing a more comprehensive and effective solution to the mental health problems they encounter.MethodsEighty-four rural left-behind children were randomly assigned to four groups: interactive video game group, LEGO game group, combined intervention group, and the control group, using a single-blind randomized controlled experiment. All participants underwent the intervention three times a week for 12 weeks. Social anxiety levels were assessed at three points: before the intervention (T0), immediately after the intervention (T1), and 6 weeks post-intervention (T2).ResultsThe effects of different intervention strategies on the social anxiety of left-behind children showed significant group-time interaction effects. As the intervention progressed, the total score of social anxiety and the scores of various dimensions among participants in different intervention groups showed a gradual decreasing trend. The combined intervention group scored significantly lower at T1 and T2 than both the interactive video game group and the LEGO group.ConclusionOur findings indicate that social anxiety in left-behind children can be significantly mitigated through both LEGO therapy and interactive video games, with a combined approach yielding the most pronounced effects. These results underscore the importance of a multifaceted intervention strategy that addresses the unique social needs of this vulnerable population. Importantly, our study suggests that effective interventions should not only focus on symptom reduction but also foster environments that enhance social skills and build confidence. Future research should investigate the scalability of these interventions across diverse contexts and their potential integration into existing mental health services to better support left-behind children.
Analyzing the cyberbullying phenomenon on social media from the perspective of students
Authors: Bularca Maria Cristina , Cristescu Sergiu , Netedu Adrian , Coman Claudiu 
Published: December 2024

IntroductionWith the significant increase in the number of social media users, the degree of cyberbullying has also increased in a directly proportional manner. Cyberbullying manifests itself in the commission of psychological abuses, teenagers being the most vulnerable.MethodsThe purpose of our paper was to analyze how the phenomenon of cyberbullying manifests in terms of frequency on social media platforms, while taking into account factors such as gender, and elements related to the behavior/reactions of witnesses and victims. We conducted a quantitative research, while having as an instrument a questionnaire. We sent the questionnaire online on the Facebook group of students from Transilvania University of Brasov, the sample of the research comprising 500 students. The quantitative method used was considered appropriate for the analysis of this phenomenon because through the questionnaire we were able to gain some insights and a more wide perspective regarding students’ perception about cyberbullying and its prevalence on social media.ResultsThe results of the research showed that respondents were aware of the existence of the phenomenon of cyberbullying on social media, and that the main forms of online bullying they experienced or witnessed referred to: ridiculing people’s physical or intellectual aspects and features, being verbally abused or threatened, being humiliated by posting sensitive content, being excluded from a group, or having their secrets publicly revealed. There were no differences found in the degree of exposure to online bullying according to gender, but the results revealed that undergraduate students, and younger students were more exposed to cyberbullying than master students and students of older age.DiscussionThe findings also highlight the fact that witnesses have an important role in the cyberbullying phenomenon. Thus, even though most of the respondents declared that they did not get involved when they witnessed cyberbullying, this results are relevant to prevention policies because they emphasize the need to develop educational campaigns regarding cyberbullying and the need to promote ethical behavior online. The results highlight the need of raising awareness and of educating young people about the phenomenon of cyberbullying, and the need of finding appropriate ways in which this phenomenon could be detected and prevented. From a theoretical point of view, the paper contributes to the literature on the forms of manifestation of cyberbullying on social media platforms, from the perspective of students. In the context of the practical implications of our paper, the results highlight the need of including information about the phenomenon of cyberbullying in the education of young people, the need of conducting awareness and prevention campaigns or programs. The paper also highlights the need of developing and implementing instruments on social media platforms, that could detect the improper behavior of users.
A multi-label text sentiment analysis model based on sentiment correlation modeling
Authors: Ni Yingying , Ni Wei 
Published: December 2024

ObjectiveThis study proposes an emotion correlation-enhanced sentiment analysis model (ECO-SAM), a sentiment correlation modeling-based multi-label sentiment analysis model.MethodsThe ECO-SAM utilizes a pre-trained BERT encoder to obtain semantic embedding of input texts and then leverages a self-attention mechanism to model the semantic correlation between emotions. Additionally, it utilizes a text emotion matching neural network to make sentiment analysis for input texts.ResultsThe experiment results in public datasets demonstrate that compared to baseline models, the ECO-SAM obtains the precision score increasing by 13.33% at most, the recall score increasing by 3.69% at most, and the F1 score increasing by 8.44% at most. Meanwhile, the modeled sentiment semantics are interpretable.LimitationsThe data modeled by the ECO-SAM are limited to text-only modality, excluding multi-modal data that could enhance classification performance. Additionally, the training data are not large-scale, and there is a lack of high-quality large-scale training data for fine-tuning sentiment analysis models.ConclusionThe ECO-SAM is capable of effectively modeling sentiment semantics and achieving excellent classification performance in many public sentiment analysis datasets.