bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studies on the effect of Celastrus orbiculatus (Celastraceae) extract on chemosensitivity of liver cancer cells via Wnt/β-catenin pathway
Authors: Ding Xiaobo , Song Laijun , Lu Yunfei , Huang Qiting , Jiao Chengming 
Published: November 2021

Purpose: To examine the efficacy of Celastrus orbiculatus extract (COE) on the chemosensitivity of liver cancer (LC) cells and its mechanism of action.Methods: Hep G2/ADM cells in the logarithmic growth phase were assigned to a control group (no treatment for cell culture medium only) and a study group (120 μg/ml COE added to the culture medium). After 48 h of incubation, the biological responses were compared. The study group wasdivided into groups A and B, while control group was divided into groups C and D, with 1 μmol/L XAV939 added in groups A and C. Cell proliferation, cell invasion, cell apoptosis rate, and apoptosis protein in the four groups were evaluated.Results: The study group showed significantly lower values in terms of cell proliferation and cell invasiveness (p < 0.05) and a higher apoptotic rate than the control group (p < 0.05)). The study group also demonstrated an elevated pro-apoptotic protein Bax level and a declined anti-apoptotic protein Bcl-2 level. In contrast to group B, the proliferation and invasiveness of Hep G2/ADM cells in group A treated with the inhibitor, XAV939, were significantly lower (p < 0.05), while the apoptotic rate exhibited a significant increase (p < 0.05). There was a rise in the level of pro-apoptotic protein, Bax, and a fall in the anti-apoptotic protein Bcl-2 level in group A. Lower levels of β-catenin, c-Myc, and cyclin D1 protein were observed in the study group compared with the control group (p < 0.05). Compared with other groups, the multiplication capacity and invasiveness of cells in group A treated with COE and inhibitor XAV939 significantly declined, while the apoptotic rate increased (p < 0.05).Conclusion: COE reverses drug resistance in chemotherapy by inhibiting the expression of Wnt/β-catenin pathway in LC cells. Therefore, COE has potentials for use along with chemotherapeutic agents in the management of liver cancer.
Language and semantics of expressions for Grafcet model synthesis in a MDE environment
Authors: NZEBOP NDENOKA Gérard , Tchuenté Maurice , Simeu Emmanuel 
Published: November 2021

The GRAphe Fonctionnel de Commande Étapes Transitions (GRAFCET) is a powerful graphical modeling language for the pecification of controllers in discrete event systems.It uses expressions to express the conditions of transitions and conditional actions as well as the logical and arithmetic expressions assigned to stored actions. However, several research works has focused on the transformation of Grafcet specifications (including expressions) into control code for embedded systems. To make it easier to edit valid Grafcet models and generate code, it is necessary to propose a formalization of the Grafcet expression language permitting to validate its constructs and provide an appropriate semantics. For this, we propose a context-free grammar that generates the whole set of Grafcet expressions, by extending the usual grammars of logical and arithmetic expressions. We also propose a metamodel and an associated semantics of Grafcet expressions to facilitate the implementation of the Grafcet language. A parser of the expressions Grafcet emph G7Expr is then obtained thanks to the generator of parsers ANTLR, while the metamodel is implemented in the Eclipse EMF Model Driven Engineering (MDE) environment. The combination of the two tools makes it possible to analyze and automatically build Grafcet expressions when editing and synthesizing Grafcet models.
Le GRAphe Fonctionnel de Commande Étapes Transitions (GRAFCET) est un puissant lan-gage de modélisation graphique pour la spécification de contrôleurs dans des systèmes à événe-ments discrets. Il fait usage des expressions pour exprimer les conditions de franchissement des transitions et des actions conditionnelles ainsi que les expressions logiques et arithmétiques assi-gnées aux actions stockées. Cependant, de nombreux travaux se sont penchés sur la transformation de spécifications Grafcet (y compris les expressions) en code de contrôle pour systèmes embar-qués. Pour faciliter l'édition de modèles Grafcet valides et la génération du code de contrôle, il est judicieux de proposer une formalisation du langage des expressions Grafcet, permettant de valider ses constructions et d'en pourvoir une sémantique appropriée. Pour cela, nous proposons une gram-maire hors-contexte qui génère tout l'ensemble des expressions Grafcet, en étendant les grammaires usuelles des expressions arithmétiques et logiques. Nous proposons également un métamodèle et une sémantique associée des expressions Grafcet pour faciliter la mise en oeuvre du langage Grafcet sous la forme d'un parseur des expressions Grafcet G7Expr obtenu grce au générateur d'analyseurs syntaxiques ANTLR, alors que le métamodèle est mis en oeuvre dans l'environnement d'Ingénie-rie Dirigée par les Modèles (IDM) Eclipse EMF. L'association des deux outils permet d'analyser et de construire automatiquement les expressions Grafcet lors de l'édition et la synthèse des modèles Grafcet.
THE UTILIZATION OF THE FIRST CEMETERY OF ATHENS IN THE EDUCATIONAL PROCESS: PRIMARY EDUCATION’S STUDENTS' PERCEPTIONS
Authors: Lambrou Chrysafia , Manesis Nikolaos 
Published: November 2021

<p>The educational use of ancient necropolises is widespread in the western world, examining them in the light of archaeological, historical, artistic and environmental interest. However, western culture does not encourage school visits to modern cemeteries, even though they are historically and artistically important monuments, such as the First Cemetery of Athens. It was founded in the 19th century on the basis of landscape architecture, adopting the aesthetics of Romanticism, as a product of a vision of an upgraded ideology for the realm of the dead and condense a wide field of learning. The educational world expresses strong doubts about the integration of the First Cemetery in the educational process, although it recognizes its multifaceted and multiple educational value. The purpose of this study is to investigate the perceptions of students in the 6th grade of Primary School about the Cemetery, to highlight the emotions that were developed and the results of the educational use of the visit to the Cemetery. The group semi-structured interview was used. The results showed the familiarity and the emotional connection that the 6th grade students developed with the First Cemetery, showing their strong desire to visit it again. Thus, the value of using cemeteries in the educational process was highlighted.</p><p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0808/a.php" alt="Hit counter" /></p>
SOCIO-PSYCHOLOGICAL DIMENSIONS OF TEACHING AND LEARNING
Authors: Akman M. Kubilay 
Published: November 2021

<p>Education is a dynamic social process with its two main components: teaching and learning. As a field of study in social sciences education science / pedagogy has a truly interdisciplinary basis. In this article we will discuss socio-psychological aspects of teaching and learning. As human beings we are all social actors: educational managers, teachers, students, parents, etc. All people have their own social responsibilities and tasks in educational activities. When we analyze and understand comprehensively this social reality it will be much more successful to establish effective strategies and apply them in society. Of course, as individuals, social groups and societies we are facing psychological interactions as well. These are very connected to people’s being social actors. This is why it is more proper to take a “socio-psychological” level of analysis for profoundly understanding educational processes. In this scientific discussion we will refer to Marx’s concepts related to education, theories in sociology of education and educational psychology. Our academic purpose is contributing to the progressive literature in education studies as broadening the discussion.</p><p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0965/a.php" alt="Hit counter" /></p>
THE ROLE OF IMPULSIVITY IN PREDICTING THE SUBJECTIVE WELL-BEING OF STUDENTS IN PRIVATE HIGHER EDUCATION
Authors: Sokić Katarina , Qureshi Fayyaz Hussain , Khawaja Sarwar 
Published: November 2021

<p>The primary purpose of this study was to investigate associations between attention impulsivity, motor impulsivity and non-planning impulsivity measured according to the Barratt Impulsiveness Scale-11 (BIS) and indicators of subjective well-being (SWB) measured by the Flourishing Scale (FS) and Personal Wellbeing Index (PWI) in students at selected private higher education institutions (N = 514, 52% women, 48% men). The aim of the current study was to explore the impact of gender on the aforementioned associations. Relationships between impulsivity and subjective well-being were examined taking into account the multifactoral structure of impulsiveness. The main findings of the study show that: (a) attention impulsivity predicted low prosperity and low levels of satisfaction with standard of living, health, personal achievements, safety and future security; (b) motor impulsivity showed bivariate but not unique relationships between prosperity and satisfaction with personal health, achievements and personal safety; (c) non-planning impulsivity was found to be uniquely associated with lower subjective prosperity and lower satisfaction with personal achievements and personal relationships; and (d) gender did not moderate the relationship between BIS components and SWB indexes. Impulsivity substrates explained between 4 and 17% of the variance in subjective well-being indexes. In sum, the results showed that the three components of impulsivity are distinct yet partially overlapping. </p><p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0998/a.php" alt="Hit counter" /></p>
THE EFFECT OF USING MENTAL COMPUTATION IN IMPROVING MATHEMATICAL PROBLEM - SOLVING ABILITY AMONG STUDENTS
Authors: Al Mashqabah Talal Tayel 
Published: November 2021

<p>The present study aimed to identify the effect of mental computation in improving the ability of university undergraduates in mathematical problem - solving. To achieve this aim, the quasi - experimental approach was used. Participants were (80) preparatory year students at Najran University in Saudi Arabia who were distributed into two main groups using the simple random sampling. One of these groups (N = 40) was assigned as the experimental group and was taught via the use of mental computation method. The second group (N = 40) was assigned as the control group and studied through the use of traditional methods. Mathematical problem - solving ability pre-test and posttest were applied to both groups. Findings showed that there were statistically significant differences between the two groups with regard to the mathematical problem- solving posttest in favor of the experimental group.</p><p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0994/a.php" alt="Hit counter" /></p>
THE INVESTIGATION OF TEACHERS’ VALUES TENDENCIES IN THE PANDEMIC PERIOD / SINIF ÖĞRETMENLERININ PANDEMİ DÖNEMİNDEKİ DEĞER EĞİLİMLERİNİN İNCELENMESİ
Authors: Yaşaroğlu Cihat 
Published: November 2021

<p>Passing through critical periods can have an impact on value systems. Our values can change in extraordinary periods such as pandemics. When the COVID-19 pandemic that affect the world is considered as one of these extraordinary situations, passing through this period may have an impact on value systems. This study was conducted to determine whether there was a change in the values of classroom teachers during the lockdown in the pandemic period. Data were collected from 224 teachers using Schwartz's Value Survey. The results of the findings analyzed descriptively were compared with the research findings collected from teacher groups using the same scale before the pandemic in the literature. Conformity was found to be the most important value in this research. Conformity value was ranked fifth, on average, in other studies. </p><p> </p><p>Kritik dönemlerden geçmek, değer sistemlerini etkileyebilir. Pandemi gibi olağanüstü dönemlerde değerlerimiz değişebiliyor. Dünyayı etkisi altına alan COVID-19 pandemisi de bu olağanüstü durumlardan biri olarak değerlendirildiğinde, bu dönemden geçmek değer sistemlerini de etkileyebilir. Bu çalışma, pandemi döneminde karantina döneminde sınıf öğretmenlerinin değerlerinde bir değişiklik olup olmadığını belirlemek amacıyla yapılmıştır. 224 öğretmenden Schwartz Değer Anketi kullanılarak veri toplanmıştır. Betimsel olarak incelenen bulguların sonuçları, literatürde pandemi öncesinde aynı ölçeği kullanarak öğretmen gruplarından toplanan araştırma bulguları ile karşılaştırılmıştır. Bu araştırmada en önemli değerin “uyma” olduğu görülmüştür. Uyma değeri, diğer çalışmalarda ortalama olarak beşinci sırada yer aldığı görülmüştür.</p><p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0957/a.php" alt="Hit counter" /></p>
THE SITUATION OF ENGLISH TEACHERS FOSTERING ACTIVITIES AT SECONDARY SCHOOLS IN KE SACH DISTRICT, SOC TRANG PROVINCE, VIETNAM
Authors: Mai Lan Yen Thi 
Published: November 2021

<p>This article aims to provide scientific, accurate and overall information on the English teachers fostering activities at secondary schools in Ke Sach district, Soc Trang province. Via the sociological survey method and direct interview, this article has informed comprehensively about the status of teachers’ quality and students’ results in learning English, English teachers’ awareness of fostering activities, implementing teaching contents under the teaching and learning foreign languages project, as well as English teachers fostering activity methods, and forms of English teachers fostering activities of educational managers. The results of the study are the basis to improve the quality of teaching and learning foreign languages for students at secondary schools in Ke Sach district, Soc Trang province.</p><p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0951/a.php" alt="Hit counter" /></p>
SOCIAL INCLUSION OF CHILDREN DIAGNOSED WITHAUTISM SPECTRUM DISORDER IN INDIA: A LITERATURE REVIEW
Authors: Samnani Malvika , Shahi Sujata , Samnani Manish , Nanda Kanika , Srivastava Mansi , Singh Pooja 
Published: November 2021

<p>Autism Spectrum Disorder is a neurodevelopmental disorder defined by insufficiency in social communication and social interaction skills and restricted and repetitive patterns of behavior. The aim of this research was to analyze empirical studies on inclusion of children with Autism in India over the past 20 years and then propose recommendations for future research. A systematic process was used to conduct the review which included identifying the data source, assessing the quality of our studies, and drawing analysis of our findings. The result included different stakeholder’s perspectives which were parents and teachers. </p><p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0986/a.php" alt="Hit counter" /></p>
Utilizing reinforcement learning and deep neural networks to optimize non-pharmaceutical COVID-19 interventions in Florida
Authors: Yang Megan , Joykutty Leya 
Published: November 2021

Under the umbrella of artificial intelligence is machine learning that allows a system to improve through experience without any explicit programs telling it to. It is able to find patterns in massive amounts of data from works, images, numbers, to statistics. One approach to machine learning is neural networks in which the computer learns to finish a task by analyzing training samples. Another approach used in this study is reinforcement learning which manipulates it environment to discover errors and rewards.
This study aimed developed a deep neural network and used reinforcement learning to develop a system that was able to predict whether the cases will increase or decrease, then using that information, was able to predict which actions would most effectively cause a decline in cases while keeping things like economy and education in mind for a better long term effect. These models were made based on Florida using eight different counties’ data including things like mobility, temperature, dates of government actions, etc. Based on this information, data exploration and feature engineering was conducted to add dimensions that would further the accuracy of the neural network. The reinforcement learning model’s actions consisted of first, a shutdown for about two months before reopening schools and allowing things to return to normal. Then interestingly the model decided to keep school operating in a hybrid model with some students going back to school while others continue to study remotely.
Cognitive Remediation Therapy for People With Schizophrenia Spectrum Disorder: A Rapid Qualitative Review
Authors: Majid Umair , Severn Melissa 
Published: November 2021

This rapid qualitative review analyzed 8 studies describing the perspectives of people living with schizophrenia spectrum disorder (SSD) who use cognitive remediation therapy (CRT), and their caregivers and clinicians.
People living with SSD reported notable improvements in their attention, memory, and problem solving; improvement in their lives when they applied the cognitive strategies acquired from CRT into daily life activities; improvement in communication skills, social engagement, motivation, independence; and a reduction in psychotic symptoms.
This review found a common preference among people living with SSD and caregivers to provide personalized delivery and treatment of CRT.
People living with SSD cited several ways to introduce personalized CRT: cognitive trainer or clinician’s support and guidance; the content, design, and implementation of CRT; using technology; and group environment and interacting with peers. The constant presence of a polite, friendly, empathetic, and encouraging clinician contributed to beneficial views of CRT.
People living with SSD enjoyed the structure of sessions and cognitive tasks, specifically working on tasks at their own pace with gradual increases in difficulty that gave them a sense of accomplishment and mastery. They also enjoyed using technology and playing games to complete tasks; however, some found accessing a computer and a high-quality internet connection difficult.
While people living with SSD reported several social benefits to group-based CRT, others found group-based CRT to be unconducive for their learning, especially when the group environment was not supportive or encouraging.
Caregivers and clinicians recognized the importance of matching the type of cognitive exercises and structure of sessions to the cognitive needs of people living with SSD.
Are You There, Law? It's Me, Semen
Authors: Bernstein Anita 
Published: November 2021

Joining a conversation about menstruation and the law, this Essay interprets “law” to mean regulation––a source of burden, constraint, and interference justified by reason. The object of my regulatory agenda is a substance perceived by Western thinkers at least since Aristotle as the superior counterpart to menstrual fluid.1 Traditions that celebrate semen as vital or affirmative, while recoiling from and controlling the other gendered emission that hurts no one, get reality backward. Law as burden, constraint, and interference ought to regulate semen and leave menstrual fluid alone.
Contrast the two substances. One of them started out with the potentially useful function of building a uterine lining. That possibility concluded, menstrual fluid is benign. The other effluvium started out with the potentially useful function of launching a pregnancy. Pregnancy is a good thing when it is desired by the person who has to live with the bulk of pregnancy’s detriments. Along with its capacity to do an important job, semen causes quite the array of harms.
A statute on point for this purpose, the Federal Hazardous Substances Act, regulates material that “may cause substantial personal injury or substantial illness during or as a proximate result of any customary or reasonably foreseeable handling or use.”2 Because semen “has the capacity to produce personal injury or illness to man through ingestion, inhalation, or absorption through any body surface,” it also aligns with the definition of “toxic” in the statute.3 Judges, policymakers, litigants, and ordinary people can all learn from well-established legal labels to understand semen as a stark example of an externality.

Nothing in this statute impedes the characterization I propose: The FHSA lists substances that lie outside its purview,4 and semen is not among them. Labeling, containment, and emergency protocols—splash protection, if you like—are the hazardous-substance safety impositions I would apply to semen.
Menopause and the Menstrual Equity Agenda
Authors: Weiss-Wolf Jennifer 
Published: November 2021

I was in fifth grade, the year 1978, and the weathered purple- and orange-covered paperback copy of Are You There God? It’s Me, Margaret. was finally mine to check out of the school library for an entire week. I read it cover to cover that first night, and surely a dozen times over in the years that followed. I have since reflected upon the extraordinary gifts Judy Blume bestowed in Margaret: enabling children to be seen, respected, and met right when and where it mattered. She validated the most mundane, yet oddly prolific, questions about periods that were clearly on the minds of many.
Four decades later, it is fair to say that the most meaningful moments of my legal career have been spent considering the very same topic—menstruation—in a quest to ensure its political centrality to issues of social justice, democratic participation, and gender equality. For my own part, commitment to menstrual equity has entailed examining our current laws and systems to see where discrimination and bias exist and persist—from public benefits to tax codes to education—and then forging the arguments to reverse that. And then, importantly, reimagining, crafting, and advancing new and more equitable policies in their place.