bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intrauterine insemination or in vitro fertilization for the treatment of Poseidon group 3 and unexplained subfertility: A propensity score matching study
Authors: Wu Yixuan , Liu Haiying , Liu Jianqiao 
Published: August 2021

Abstract
Background

Although it is becoming an increasingly significant indication for in-vitro fertilization (IVF), no studies have been done to examine the efficacy of IVF and intrauterine insemination (IUI) for the treatment of young patients with unexplained infertility and low ovarian reserve. The goal of this research was to compare the efficacy of IVF with IUI on Poseidon group 3 patients with unexplained infertility (PG3&UI).
Methods

This was a retrospective analysis of PG3&UI patients who had IVF/intracytoplasmic sperm injection (ICSI) or IUI at the Third Affiliated Hospital of Guangzhou Medical University between January 1, 2015, and March 31, 2021. To equalize the baseline characteristics of the IVF and IUI groups, propensity score matching (PSM) was utilized. Intention-to-treat (ITT) and per-protocol (PP) analyses were used to compare the differences in live births. To discover variations in time to biochemical pregnancy leading to live birth, Kaplan-Meier curves were produced. To evaluate the expenses per live birth between two procedures, a cost-effective analysis was done.
Results

According to ITT analysis, the live birth rate for the IVF group was substantially higher than the cumulative live birth rate (CLBR) for the IUI group (22.6% (38/168) vs. 11.3% (19/168), RR 2.00, 95% CI 1.20–3.32, P = 0.006). In the PP analysis, the live birth rate was 23.0% (38/165) in the IVF group and 11.7% (19/162) in the IUI group (RR = 1.96, 95% CI 1.18–3.26, P = 0.007). When censored at 365 days, the Kaplan-Meier analysis revealed that the IVF group had a higher live birth rate than the IUI group (log-rank test χ²= 6.025; P = 0.014). However, when the two groups were censored at 180 days, the live birth rates were not substantially different (log-rank test χ²= 3.847; P = 0.05). The number of visits per live birth in the IUI group was higher than in the IVF group (85 vs. 48). The overall cost of a live birth was comparable across the two groups (¥132242 vs. ¥131611), while the medical expenses for a live delivery from IVF were higher than those from IUI ((¥118955 vs. ¥108279).
Conclusions

The livebirth rate per IVF cycle with at most one embryo transfer is higher than the CLBR of IUI, with fewer hospital visits and similar expenses.
Wearable Pressure Sensors Based on Carbonized Graphene Coated Waste Paper Aerogel
Authors: Li Ang , Cui Ce , Wang Weijie , Zhang Yue , Zhai Jianyu , Guo Ronghui , Lin Shaojian , Qin Wenfeng , Ren Erhui , Xiao Hongyan , Zhou Mi , Zhang Jinwei 
Published: August 2021

Abstract
Graphene is complexed with cellulose fibers to construct 3D aerogels, which is generally considered to be an environmentally friendly and simple strategy to achieve wide sensing, high sensitivity and low detection of wearable piezoresistive pressure sensors. Here, graphene is incorporated into waste paper fibers with cellulose as the main component to prepare graphene coated waste paper aerogel (GWA) using a simple “filtration-oven drying” method under atmospheric pressure. The GWA was further annealed to obtain the carbonized graphene coated waste paper aerogel (C-GWA) to achieve low density and excellent resilience. The result shows that the C-GWA has a rough outer surface due to the 3D structure formed by interpenetrated fibers and the carbon skeleton with wrinkles. The sensor based on GCA shows low density (25mg/cm3), a wide detection range of 0-132 kPa, an ultra-low detection limit of 2.5 Pa (a green bean, ≈ 53.4 mg), and a high sensitivity of 31.6 kPa− 1. In addition, the sensor based on C-GWA with the excellent performance can be used to detect human motions including the pulse of the human body, cheek blowing and bending of human joints. The result indicates that the sensor based on C-GWA shows great potential for wearable electronic products.
Sustainable management of recycled wastewater – A case study
Authors: rani sudha Pendyala , Naresh Nalla , Gurijala Akhil 
Published: August 2021

Abstract
Waste water reuse is considered as a best solution to climate change adaptation, lack of water service and sanitation in rural areas in particular. The proposed method was the implementation of a real case which describes the benefits of application of treated waste water in Guru Nanak Institution of Technology, Hyderabad for ground water recharge and miscellaneous purposes. The waste water was analyzed for physical and chemical parameters before and after treatment and were compared with WHO, Indian standards and FAO irrigation standards. DO and BOD, Total hardness, Calcium, Magnesium, chlorides and sulphates were found in high concentration as compared to standard values. Hence, infiltration basins filled with filter media were designed and constructed in the campus to recharge ground water. Therefore treated waste water was passed through infiltration beds consisting of Coarse River sand, wood charcoal, 3/4th inch gravel, ¾ inch Granite stones and river boulders. Final analysis was done after filtration. BOD of the filtered water was reduced Ca2+, Mg2+, T.H, Cl and So42− were reduced .The research suggests that the waste water after treatment and filtration could be used for ground water recharge .This study provides an exploratory investigation into advantages of managing recycled waste The paper also provides evidence that an Integrated planning and approach is necessary for the waste water management in a water stressed basin. This work is a challenge for the present and also for the future.
WITHDRAWN: The Impact of Addiction on Academic Performance of Students: the Case of Wolaita Sodo University, Ethiopia
Authors: Bojago Elias , Wendimu Abenezer 
Published: August 2021

Abstract
Background: The high prevalence of substance use and its association with poor academic performance is a global concern today. Objective: The study was conducted to assess the impact of addiction on the academic performance of students in the case of Wolaita Sodo University. Methods: Cross-sectional study was carried out among a total of 421 students selected by using the cluster sampling technique. Data were collected via semistructured questionnaires and interviews and analyzed using descriptive and inferential statistics.Results: The results showed that, from the total sample of students, 71.8% of the respondents were involved in addiction while the rest 28.2% were free from any addiction and 73.1% males were more likely to be addicted than females (26.9%). The chi-square result also shows that addiction and academic performance were found to be dependent and addicted students were associated with poor academic achievement than nonaddicted. The regression dummy variable test also showed that the students involved in addiction recorded a lower academic results by 0.587 than addiction free students.Conclusion: Behavioral and physiological addiction to illicit substances and other stimulants is common in Wolaita Sodo University as in other higher education institutions. The common practice of substance use and its association with poor academic performance demand universities to have a good control of the substance and to implement youth friendly activities. The effects of addiction might be better studied through pertinent, vigorous research.
A Modificatory Screening Protocol for ARDS in Patients with Respiratory Support Based on SpO2 and FiO2
Authors: Xia Yan , Xu Qiancheng , Guo Zhiyuan , Zhang Huijuan , Cao Yingya , Qi Yupeng , Chen Qun , Lu Weihua 
Published: August 2021

Abstract
Background: A large number of recent studies have confirmed that the pulse oximetric saturation (SpO2)/fraction of inspired oxygen (FiO2) ratio (SFR) correlate well with PaO2/FiO2 ratio (PFR). However, whether SFR can replace PFR for the diagnosis and evaluate the severity of ARDS patients with advanced respiratory support is unclearly. The purpose of this study is to explore potential value of SFR ratio as a new diagnostic tool for ARDS by establishing new processes in patients who require high levels of oxygen support.Methods: 341 patients were included in this study, SFR and PFR values were recorded in the same time. 161 patients were used to establish the model, and 180 patients were used to verify the validity of the model. 161 groups of data were divide into hypoxic group (group H) and non-hypoxic group (group N) according to whether SpO2 was greater than 97%. For group H, the regression equation was established to describe the relationship between SFR and PFR. and calculated the value of SFR when PFR is 300. For group N, the correlation between each observation data andPFR were analyzed. Receiver operating characteristic (ROC) curve analysis was used to determine the diagnostic value of the index. Finally, a new diagnostic process was established for ARDS based on these results, and the reliability was verified with Berlin definition set as the gold standard for diagnosis and classification. Results: For group H, the diagnostic linear equation is PFR = 0.9162*SFR-21.39 ( R2=0.66 , P<0.0001 ). After calculation, when PFR is 300, SFR is 352. For group N, There is a significant negative correlation between FiO2 and PFR((R= -0.521,P<0.0001)). The AUC of using FiO2 to diagnose ARDS was 0.694 (95%CI 0.571~0.817, P ＜ 0.005). When the cutoff value of FiO2 was 39%, the sensitivity was 0.838 and the specificity was 0.545. Therefore, in this new diagnosis progress, when SpO2≤97%, if SFR≤352, ARDS may exist; when SpO2>97%, if FiO2min>39%, there may be ARDS. The sensitivity, specificity, NPV, PPV, and accuracy of the new diagnosis progress for ARDS were 91.1%, 76.7%, 89.6%, 79.6%, and 83.9%, respectively. Conclusion: There are potential value of SpO2 and FiO2 as a noninvasive diagnostic tool for ARDS by new processes in patients who are already receiving high levels of oxygen support.
Computational Drug Discovery in Patients with Endometriosis-Induced Infertility via Text Mining and Biomedical Databases
Authors: Lin Yingying , Chen Zhiwei , Huang Jianping , Fang Jiaoning , Qi Yuanjie , Xie Li , Chen Li , Li Hua 
Published: August 2021

Abstract
Background: Endometriosis (EMT) is the most common benign gynecological disease among women of reproductive age, causing infertility and seriously affects women's physical and mental health. However, the current treatment was not always effective. This study was designed to use publicly available data to identify drugs targeting the relevant gene with EMT-induced-infertility using computational tools.Methods: EMT and infertility genes were determined by text mining, and the GeneCodis program was used to analyzed gene ontology of the intersection of the two gene sets. A string database was used to analyze the protein-protein interaction network. The Drug-Gene Interaction database is queried for the rich gene set belonging to the identified pathways to find drug candidates that can be used in EMT-induced infertility.Results: Our analysis identified 550 genes common to both the EMT and infertility by text mining. Gene enrichment analysis and protein-protein interaction analysis found 39 genes potentially targetable by a total of 49 drugs that could be formulated for application, which have not been used in EMT-induced infertility. Conclusions: The findings from the present analysis can facilitate the Identification of existing drugs that have the potential of topical administration to improve EMT-induced infertility and present tremendous opportunities to study novel targets pharmacology using in silico text mining and pathway analysis tools.
What is the Importance of Psychological Measures to Determine Readiness to Return to Sports After Anterior Cruciate Ligament Reconstruction?
Authors: Newmarch Tate , Betsch Marcel , Michalik Roman , Dwyer Tim , Whelan Daniel , Chahal Jaskarndip , Theodoropoulos John 
Published: August 2021

Abstract
Background: Recent studies have suggested that psychological factors are important components of successful return to sports (RTS) after anterior cruciate ligament reconstruction (ACLR). The purpose of this study was to survey physicians on their criteria used to determine readiness to RTS after ACLR and understand the significance of psychological factors on RTS.Methods: A survey was designed to understand the practices of clinicians managing rehabilitation after ACLR consisting of 25 questions divided in 3 different sections, including one section about psychological scores and factors affecting RTS. The survey was delivered to three North-American orthopaedic sports medicine organizations.Results: The total number of respondents was 113. 95% of respondents considered psychological tests at least “somewhat important” (33% “important”, 23% selected “very important”). Routine use of psychological tests in practice was only reported by 35% of respondents. The ACL-Return to Sport after Injury Scale was the most frequently used psychological test (23%). Fear of reinjury was considered the most common patient-cited psychological factor affecting RTS. Psychological factors ranked 8th out of 9 outcomes measures in determining readiness to RTS.Conclusion: This study demonstrates a discrepancy between the importance of psychological tests and the frequency of use in practice. Additional education on this topic, web-based applications and a multidisciplinary approach may increase the usage of psychological tests to determine RTS after ACLR.
Safety of Dihydroartemisinin-piperaquine Versus Artemether-lumefantrine for the Treatment of Uncomplicated Plasmodium Falciparum Malaria Among Children in Africa: A Systematic Review and Meta-analysis of Randomized Control Trials
Authors: Assefa Dawit Getachew , Yesmaw Gizachew , Makonnen Eyasu 
Published: August 2021

Abstract
Background: The efficacies of artemisinin based combinations have been excellent in Africa, but little or no attention has been given to their safety. The aim of this review was to synthesize available evidence on the safety of dihydroartemisinin-piperaquine (DHA-PQ) compared to artemether-lumefantrine (AL) for the treatment of uncomplicated P.falciparum malaria among children in Africa.Method: A systematic literature search was done to identify relevant articles from online databases PubMed/ MEDLINE, Embase, and Cochrane Center for Clinical Trial database (CENTRAL) for retrieving randomized control trials comparing safety of DHA-PQ and AL for treatment of uncomplicated P.falciparum malaria among children in Africa. The search was performed from August 2020 to 30 April 2021. Using Rev-Man software (V5.4.1), the extracted data from eligible studies were pooled as risk ratio (RR) with 95% confidence interval (CI).Result: In this review, 18 studies were included, which involved 10,498 participants were included. Compared to AL, DHA-PQ was associated with a slightly higher frequency of early vomiting (RR 2.26, 95% CI 1.46 to 3.50; participants = 7796; studies = 10; I2 = 0%, high quality of evidence), cough (RR 1.06, 95% CI 1.01 to 1.11; participants = 8013; studies = 13; I2 = 0%, high quality of evidence), and diarrhea (RR 1.16, 95% CI 1.03 to 1.31; participants = 6841; studies = 11; I2 = 8%, high quality of evidence) were more frequent in DHA-PQ treatment arm.Conclusion: From this review, it can be concluded that early vomiting, diarrhea, and cough were significantly more frequent in patients who were treated with the DHA-PQ than that of AL, and both drugs are well tolerated. More studies comparing AL with DHA-PQ are needed to determine the comparative safety of these drugs.
Single-incision Non-weight-bearing Area Autologous Osteochondral Transplantation for the Treatment of Osteochondral Lesions of the Talus
Authors: Zhang Yan , Liang Jing-qi , Wen Xiao-dong , Liu Pei-long , Lu Jun , Zhao Hong-mou 
Published: August 2021

Abstract
Background: Autologous osteochondral transplantation (AOT) is one of the most effective treatments for osteochondral lesions of the talus (OLTs). Normally, medial malleolar osteotomy is used to expose posteromedial lesions. However, medial malleolar osteotomy causes additional ankle injuries and a risk of persistent pain in the ankle joint. The purpose of the current study was to evaluate a new medial malleolar triplane osteotomy method and the functional outcomes of AOT from a non-weight-bearing area of the talus for OLTs.Methods: Twenty-three patients (23 ankles), including 14 males and 9 females, received AOT with triplane osteotomy of the medial malleolus for symptomatic OLTs between September 2015 and December 2017. The mean age was 35.6 years. The mean size of the lesion area was 141.5 mm2. The visual analog scale (VAS) for pain during walking and the American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot score were used for the pre- and postoperative evaluations. In addition, the incorporation of the grafts was assessed by computed tomography (CT).Results: All patients had a minimum follow-up of 22 months, with an average of 37.1 months. The mean time from osteotomy to full weight-bearing activity was 8.1±2.3 weeks (range, 5-12 weeks). The VAS score improved from 4.34 preoperatively to 0.53 postoperatively (P <0.01). The AOFAS ankle-hindfoot score improved significantly in all domains (P<0 .01). Twenty-one patients returned to sport at their previous level, and 2 returned at a lower level compared with preinjury (mean return to play, 7.4 months). According to CT, the medial malleolus recovered in all patients, and the graft was incorporated well. One patient suffered from flexor hallucis longus tendon discomfort due to internal fixation screw irritation posteromedial to the ankle. The general complication rate was 4.3% (1/23).Conclusions: AOT combined with medial malleolus triplane osteotomy is a viable option for OLTs. Patients could perform weight-bearing exercise and return to sport as early as possible, with few complications at the osteotomy site and donor site.
Rebound Iritis With a Well-circumscribed Anterior Chamber Fibrin Mass After Uncomplicated Cataract Surgery
Authors: Raval Nilesh , Yao Wen-Jeng , Kim Gene , Kang Joann J. 
Published: August 2021

Abstract
Purpose: To describe a case of bilateral rebound iritis complicated by a subacute, transient, well-circumscribed anterior chamber mass.Methods and Observations: Observational case report of a 59-year-old female with recent ocular history of bilateral cataract surgery and poor post-operative medication compliance who was found to have bilateral rebound iritis and a globular, pedunculated anterior chamber mass attached to the posterior chamber intraocular lens in the right eye. Slit lamp photographs were taken, and after three days of topical steroid administration, the mass resolved with only a mild, residual iritis.Conclusions and Importance: Post-operative fibrinous exudates are occasionally encountered immediately after intraocular surgery, however, there have been no reports in the literature to the best of our knowledge of a subacute anterior chamber mass in such a well-circumscribed configuration as we report. This case study raises awareness of a peculiar structural form in which a subacute, post-operative fibrin clot may present.
Impact of Potential Modifications to Alzheimer’s Disease Clinical Trials in Response to Disruption by COVID-19
Authors: Schneider Lon S , Qiu Yuqi , Thomas Ronald G , Evans Carol , Jacobs Diane M. , Jin Shelia , Kaye Jeffrey A. , LaCroix Andrea Z. , Messer Karen , Salmon David P , Sano Mary , Schafer Kimberly A. , Feldman Howard H. 
Published: August 2021

Abstract
BackgroundThe COVID-19 pandemic disrupted Alzheimer disease randomized clinical trials (RCTs)forcing investigators to make changes in the conduct of such trials while endeavoring to maintain their validity. Changing ongoing RCTs carries risks for biases and threats to validity. To understand the impact of exigent modifications due to COVID-19 we examined several scenarios in symptomatic and disease modification trials that could be made.MethodsWe identified both symptomatic and disease modification Alzheimer disease RCTs as exemplars of those that would be affected by the pandemic and considered the types of changes that sponsors could make to each. We modeled three scenarios for each of the types of trialsusing existing datasets, adjusting enrollment, follow-ups, and dropouts to examine the potential effects COVID-19-related changes.Simulations were performed that accounted for completion and dropout patterns using linear mixed effects models, modeling time as continuous and categorical. The statistical power of the scenarios was determined.ResultsTruncating both symptomatic and disease modification trials, led to underpowered trials.By contrast, adapting the trials byextending the treatment period, temporarily stopping treatment, delaying outcomes assessments, and performing remote assessment allowed for increased statistical power nearly to the level originally planned.DiscussionThese analyses support the idea that disrupted trials under common scenarios are better continued and extended even in the face of dropouts, treatment disruptions, missing outcomes, and other exigencies, and that adaptations can be made that maintain the trials validity. We suggest some adaptive methods to do this noting that some changes become under-powered to detect theoriginal effect sizes and expected outcomes. These analyses provide insight to better plan trials that are resilient to unexpected changes to the medical, social, and political milieu.
More than a Spacer: The Bacterial Promoter Spacer Modulates Promoter Strength and Timing by Length, Sequence, TG-Motifs and DNA Supercoiling Sensitivity
Authors: Klein Carlo A. , Teufel Marc , Weile Carl J. , Sobetzko Patrick 
Published: August 2021

Abstract
Transcription, the first step to gene expression, is a central coordination process in all living matter. Besides a plethora of regulatory mechanisms, the promoter architecture sets the foundation of expression strength, timing and the potential for further regulatory modulation. In this study, we investigate the effects of promoter spacer length and sequence composition on strength and supercoiling sensitivity in bacteria. Combining transcriptomics data analysis and standardized synthetic promoter libraries, we exclude effects of specific promoter sequence contexts. Analysis of promoter activity shows a strong variance with spacer length and spacer sequence composition. A detailed study of the spacer sequence composition under selective conditions reveals a, RNAP binding enhancing but expression damping, extension to the –10 region. Using physiological changes in DNA supercoiling levels, we link promoter supercoiling sensitivity to overall spacer GC-content. Time-resolved promoter activity screens, only possible with a novel mild treatment approach, reveal strong promoter timing potentials solely based on DNA supercoiling sensitivity in the absence of regulatory sites or alternative sigma factors.