bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peningkatan Keterampilan Bertanya (Posing Question) melalui Penerapan Discovery Learning pada Materi Ekosistem di Kelas X Imersi 1 SMA Negeri 2 Karanganyar Tahun Pelajaran 2013/2014
Authors: Wijayanti Rina , Widoretno Sri , Santosa Slamet 
Published: March 2021

<p>This research’s aim is to improve the posing question skill of the students in X Imersi 1 of SMA Negeri 2 Karanganyar academic Year 2013/2014 about ecosystem material through discovery learning application. This research is a class action research which consists of three cycles. Each cycle contains planning, implementing, observing and reflecting. The research subject is the students in X Imersi 1 of SMA Negeri 2 Karanganyar Academic Year 2013/2014. The data source is from the questions that cover the quantity and quality of the question. The question’s quantity is counted from the sum of questions that is given by the students while the question’s quality is counted from the sum of questions’ kind that is given by the students based on their thinking process and knowledge dimension. Data collecting techniques of this research are using observation, interview and documentation then data validation is using triangulation method. Data analyzing technique of this research is descriptive qualitative analysis which is done in three components, they are: data reduction, data presentation and drawing the conclusion or verification. The research’ procedure is using spiral mode which is interdependent. The result of the research shows that the implementation of discovery learning improves the students’ posing question skill that covers the quantity and quality of the question. The question’s quantity improvement from pre-cycle to the first cycle is 70 questions, the first cycle to the second cycle is 46 questions and the second cycle to the third cycle is 20 questions. Then the question’s quality improvement from pre-cycle to the first cycle is 29,16%, the first cycle to the second cycle is 17,18% and the second cycle to the third cycle is 16,14%. This research’s conclusion is the implementation of discovery learning can improve the posing question skill of the students in X Imersi 1 of SMA Negeri 2 Karanganyar academic Year 2013/2014 about ecosystem material.</p><p align="center"> </p><p>Key Words: discovery learning, posing question skill</p>
PENERAPAN PROBLEM BASED LEARNING PADA MATERI PENCEMARAN LINGKUNGAN UNTUK MENINGKATKAN KEMAMPUAN BERPIKIR KRITIS PESERTA DIDIK KELAS X MIA 3 SMA NEGERI 3 SURAKARTA
Authors: Astuti Hesti Retno Puji , Prayitno Baskoro Adi , Suwarno Suwarno 
Published: March 2021

<p>The purpose of this research is to improve student’s critical thinking skill on Environmental Pollution Subject at class X MIA 3 of SMA Negeri 3 Surakarta. The research is a Classroom Action Research with 2 cycles of action. Each cycle consist of 4 phases which is planning, acting, observing, and reflecting. The result of the observations showed, 1) interpretation skill 43.97%, 2) analysis 29.31%, 3) evaluation 32.76%, 4) inference 43.10%, 5) explanation 53.45%, and 6) self-regulation 52.59%. Average of students’ critical thinking skill procentage is 42,53%. The method of data collection is through observation, tests, and documentation. Technical analysis of data is technical qualitative descriptive. Data validation is use triangulation methods. The results of the application of <em>Problem Based</em> <em>Learning</em> on Environmental Pollution Subject showed an increase of students’ critical thinking skill. Students’ critical thinking skill in the first cycle is 70,83%. Students’ critical thinking skill in the second cycle is 75%. Based on the result of the research, we can conclude that the application of <em>Problem Based</em> <em>Learning</em> on Environmental Pollution Subject in general can improve students’ critical thinking skill at class X MIA 3 of SMA Negeri 3 Surakarta, despite the increase that occurs varies in each cycle.</p><p><em> </em></p><p><em>Keywords : </em>Critical Thinking Skill, Problem Based Learning</p>
Teknik Instruksional Pertanyaan Guru Di Tahap Evaluating Data, Driving A Conclusion, Presenting The Project In Class As Preffered & Discussion Project Based Learning Untuk Meningkatkan Skor Valid Relationship Concept Map
Authors: Rahayu Yacinta Arum Dwi , Rinanto Yudi , Widoretno Sri 
Published: March 2021

<p>This research aimed to calculate the valid relationship score of concept map (CM) using instructional technique of teacher’s questions in the stages of evaluating data, driving a conclusion, presenting the project in class as preferred &amp; discussion project-based learning. This research was a classroom action research. This research was a classroom action research with the research subject of 36 students in X MIPA of Senior High School. The research procedure was including: planning, lesson plan completed with assessment, acting, observing and reflecting. Validity test in this research was using triangulation method that consisted of verification of valid relationship CM score, documentation based on expert CM and interview to present the valuable relation between concepts. Reduction done to choose the data completion, data interpretation and conclusion based on the complete valid relationship data. Data analysis was using descriptive qualitative. The result of this research shows that valid relationship score of expert CM in pre-research, cycle I and cycle II were written as follows. 1.95%-14.98% with 13.89% of the under averaged students’ score and 11.11% of the over averaged students’ score. 3.08%-61.54% with 19.44% of the under averaged students’ score and 11.11% of the over averaged students’ score. 16.58%-32.16% with 11.11% of the under averaged students’ score and 16.67% of over averaged students’ score. Thus, the use of instructional technique of questioning in the stages of evaluating data, driving a conclusion, presenting the project in class as preferred &amp; discussion project-based learning improving the valid relationship CM score on the individual and classical.</p><p> </p>
Pengaruh Media Pembelajaran Natural Picture Terhadap Hasil Belajar Siswa Pada Mata Pelajaran IPA
Authors: Rudianto Ruril , Nurtjahyani Supiana Dian 
Published: March 2021

<p class="5abstrak">Science is a science that learns about life in the world from all aspects. To be able to study these subjects requires a deeper understanding of the material. Application of learning innovations needs to be done to achieve the objectives of science subjects especially by teachers so as to provide hands-on experience for students to acquire innovative learning. Based on the observations at SMP Negeri 1 Bancar known that the results obtained by students less satisfactory. The process of teaching and learning is done by lecture method, when the learning process takes place many students are sleepy and chatting. To improve the learning outcomes in science subjects especially biology required the existence of learning innovation, namely by using Natural Picture learning media. The purpose of this study is to determine whether there is an influence of Natural Picture learning media on student learning outcomes in science biology subjects in SMP Negeri 1 bancar. The type of research used is Quasi Eksperimen. This research was conducted at SMP Negeri 1 Bancar with research sample that is student of class VII A which amounted to 32 students as experiment class and student of class VII E which amounted to 32 students as control class. The research design used was Pre-Test research design - Post-Test Control Group Design. Based on the results of data analysis of learning results, the average value in the experimental class given treatment using Natural Picture learning media is higher than the control class using the lecture method. The experiment class is 87.12 and the control class is 74.37. In the hypothesis test the Sig value. (2-tailed) of 0.000, when compared with α 0.05 then Sig &lt;α then H0 is rejected and H1 accepted. Thus, it can be concluded that there is a difference in mean values of experimental class learning outcomes and control classes. That is, there is the effect of learning media Natural Picture on student learning outcomes.</p><p class="6keyword"> </p>
Congratulations! Best Paper Award 2011
Authors: Office Editorial 
Published: March 2021

The second Best Paper Award ceremony was held in Kasumigaseki, Tokyo, Japan, on July 29, attended by the winner and IJAT committee members who took part in the selection process for IJAT, Vol.4 (2010). The award winner(s) will also be announced on the IJAT website and given a certificate and a nearly US$1,000 honorarium.
The Best Paper Award 2011 is as follows:
Title: Adaptive Cutting Force Prediction in Milling Processes
Authors: Takashi Matsumura, Takahiro Shirakashi, and Eiji Usui
IJAT, Vol.4, No.3, pp. 221-228, 2010
Congratulations! Best Paper Award & Best Review Award 2013
Authors: Office Editorial 
Published: March 2021

The fourth Best Paper Award 2013 and the first Best Review Award 2013 ceremony was held in Kasumigaseki, Tokyo, Japan, on August 2, 2013, attended by the winner and IJAT committee members who took part in the selection process. The Best Paper was severely selected from among 81 papers published in Vol.6 (2012) and the Best Review was selected from 9 reviews published from 2010 to 2012. The Best Paper Award winner was given a certificate with a nearly US$1,000 honorarium and the Best Review Award winner was given a certificate with commemorative shield.

The Best Paper Award 2013 is as follows:
Title: Estimation of Dynamic Mechanical Error for Evaluation of Machine Tool Structures
Authors: Daisuke Kono, Sascha Weikert, Atsushi Matsubara, and Kazuo Yamazaki
Int. J. of Automation Technology Vol.6 No.2, pp. 147-153, March 2012

The Best Review Award 2013 is as follows:
Title: Indirect Measurement of Volumetric Accuracy for Three-Axis and Five-Axis Machine Tools: A Review
Authors: Soichi Ibaraki and Wolfgang Knapp
Int. J. of Automation Technology Vol.6 No.2, pp. 110-124, March 2012
Herramientas de mercadeo tradicional y digital utilizadas por grandes empresas ubicadas en países en vías de desarrollo y su relación con el desempeño exportador: el caso de Costa Rica
Authors: Quirós-Gómez Josué , Arce-Gutiérrez Susan 
Published: March 2021

Rev.esc.adm.neg
Las exportaciones juegan un papel clave en el desarrollo económico de los países. Estas se han visto beneficiadas por el uso de internet, según estudios previos. No obstante, la literatura no es clara con respecto a la relación que existe entre las herramientas de mercadeo digital y tradicional con el desempeño exportador de grandes empresas ubicadas en países en vías de desarrollo. Con el fin de determinar si existe esta relación y, además, identificar cuáles herramientas poseen un mayor impacto en este tipo de organizaciones, se desarrolla la presente investigación. Se basa en una metodología cualitativa por medio de entrevistas a profundidad realizadas a empresas con más de cien colaboradores ubicadas en Costa Rica, las cuales fueron analizadas con el software Atlas.TI8. Los resultados apuntan a que efectivamente existe la posible relación descrita, y cómo, a pesar de que se evidencia la relevancia que tienen las herramientas de mercadeo digital en la actualidad, existe una predominancia de las herramientas tradicionales. El análisis permite concluir que cada vez son más las compañías que manejan las herramientas de mercadeo digital a nivel interno dentro la organización, debido a la importancia de estas para el logro de los objetivos, además fue posible identificar que las empresas estudiadas han logrado un equilibrio entre mantener las actividades de mercadeo tradicional e incursionar en el uso del mercado digital.
Decreased peripheral blood lymphocyte-monocyte ratio and platelet-monocyte ratio and the Peripheral Blood Score model predict poor survival in peripheral T-cell lymphoma patients
Authors: Zhang Yan , Shi Yuanfei , Shen Huafei , Shou Lihong , Fang Qiu , Zheng Xiaolong , Zhu Mingyu , Huang Xin , Huang Jiansong , Li Li , Zhou De , Zhu Lixia , Zhu Jingjing , Ye Xiujin , Jin Jie , Xie Wanzhuo 
Published: March 2021

Abstract
Background Peripheral T-cell lymphoma(PTCL) is a group of lymphoproliferative tumors originated from post-thymic T cells or mature natural killer (NK) cells. It shows highly aggressive clinical behaviour, resistance to conventional chemotherapy, and a poor prognosis. Its incidence rate in China is 1 to 2 times higher than in western countries. Therefore, optimal strategies for identifying high-risk patients are urgently needed. Materials and Methods We retrospectively studied 347 newly diagnosed PTCL patients from January 2011 to October 2019 and analyzed the relationship between peripheral blood lymphocyte-monocyte ratio (LMR) and platelet-monocyte ratio (PMR) and prognosis. The model of Peripheral Blood Score was established to screen out high-risk patients. Results The receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value based on survival rate. It was found that patients with PTCL with LMR ≤ 1.68 and PMR ≤ 300 had inferior overall survival (OS) and the difference was significant in both low-risk (P<0.001) and medium high-risk (P<0.001) groups of IPI score. In multivariate analysis, LMR ≤ 1.68 (HR=1.751, 95% CI 1.158-2.647, p=0.006), PMR ≤ 300 (HR=1.762, 95% CI 1.201-2.586, p=0.002), stage III-IV (HR=3.276, 95% CI 1.512-7.099, p=0.003), Eastern Cooperative Oncology Group (ECOG) score 3-5 (HR=2.351, 95% CI 1.647-3.356, p<0.001) and extra-nodal invasion more than one site (HR=1.659, 95% CI 1.125-2.445, p=0.039) were independently associated with short survival. LMR and PMR were integrated into "Peripheral Blood Score (PBS)" model. PTCL patients were divided into three risk groups: low-risk group, medium risk group and high-risk group. The 1-year OS was 86%, 55.3% and 22.6%, and the 3-year OS was 43.4%, 20% and 13.1%, respectively. Conclusion Overall, LMR and PMR can be used as early prognostic indicators in PTCL patients. Moreover, we can easily detect the complete blood cell count (CBC), and use PBS model to preliminarily screen and stratify patients. It is simple, convenient and accurate to screen out patients with short lives, and formulate personalized treatment strategies.
Characteristics, Comorbidities, and Outcomes Among Patients Admitted With COVID-19 in Sheikh Khalifa Medical City: A Retrospective Study
Authors: Abdelwahab Moustafa , Qadi Lara Al , Jawabreh Mohammad Al , Sulaiman Hanan , Blooki Mariam Al 
Published: March 2021

Abstract
Background: Many studies were published to describe the clinical characteristics of COVID-19, however there is still lack of knowledge and it’s time to take stock of the war against coronavirus disease 2019 (COVID-19) pandemic before we hit another million in a matter of days. Simply Identifying COVID-19 features will help in mapping the disease and guiding pandemic management. A retrospective review, retrospective study was initiated in SKMC to describe the demographic data, clinical characteristics, and outcomes of COVID-19 cases who were hospitalized during that period.Methods: Confirmed positive COVID-19 sample patients from April 1st 2020 to May 31st 2020 in Sheikh Khalifa Medical City. Clinical characteristics, Demographic data, incubation periods, laboratory findings, and patient outcomes data retrieved from 336 cases in the electronic medical chart (SALAMTAK).Results: The median age was 44 years and 83.9% (n = 282) of the patients were men. The patients with diabetes mellitus being the most common risk factor (25.0%), followed by hypertension (22.9%) and Age ≥60 were (13.4%). Total 36 patients (10.7%) were asymptomatic. The most common symptoms were upper respiratory tract symptoms, manifested as dry cough (70.2%), and followed by fever (54.2%), shortness of breath (43.5%), headache (25.9%) and sore throat (25.3%). Less common symptoms were diarrhea (16.7%) chest pain (14.6%). The maximum length of stay is 32 days. The minimum length of stay in [ICU/HDU] was 1 day and the maximum was 21 days.Conclusion: In this retrospective study, fever and cough were common symptoms. Special attention should be given to patients with risk factors especially patients with one risk factor such as diabetic patients, patients with hypertension and older patients over 60 years as they are the most highly prevalent in this case series. Disease was affecting males and D-dimer was significantly elevated in deceased patients.
Refractive Error Induced by Intraocular Lens Tilt After Intrascleral Intraocular Lens Fixation
Authors: TOKUHISA TERUAKI , WATANABE TOMOYUKI , WATANABE AKIRA , NAKANO TADASHI 
Published: March 2021

Abstract
Purpose To investigate the spherical shift of Intraocular lens (IOL) tilt after intrascleral fixationMethods We retrospectively reviewed the medical records of patients who underwent flanged intrascleral IOL fixation with transconjunctival 25- or 27-gauge pars plana vitrectomy at the Department of Ophthalmology of Jikei University Hospital with a minimum follow-up duration of three months. Second-generation anterior segment optical coherence tomography (CASIA2; TOMEY) was used to obtain the tilt and decentration of intrasclerally fixated IOL and postoperative anterior chamber depth. We investigated the relationship of the refractive error with these parameters, axial length, and keratometry. In addition to the clinical investigation, we performed optical simulations using the Zemax optical design program for studying the spherical shift of the IOL tilt by means of the through-focus response and change of spherical equivalent power.Results The study involved 72 eyes of 67 patients. The degree of IOL tilt was correlated with the amount of refractive error (Spearman's rank correlation coefficient [CC] = −0.32; P = 0.006). In particular, a tilt angle greater than 10° strongly influenced the refractive error. Postoperative anterior chamber depth also correlated with the refractive error (CC = 0.50; P < 0.001). The refractive error did not correlate with decentration (CC = −0.17; P = 0.15), axial length (CC = −0.08; P = 0.49), and keratometry (CC = −0.06; P =0.64). Optical simulations using the Zemax optical design program also showed a myopic shift exponentially as the tilt becomes greater. Conclusion An IOL tilt greater than 10 ° induces refractive error.
Quality of life of caregivers of patients with gastrointestinal cancer: The influence of sex, age, and stage of the cancer patients
Authors: Rosa Lilian Nascimento , Forones Nora Manoukian 
Published: March 2021

Abstract
Purpose: The caregivers of cancer patients may experience changes in their routine and environment that affect their quality of life. The aim of the study was to identify the domains that compromise the quality of life of the caregivers of patients with gastrointestinal cancer (GIC). Methods: A descriptive, observational study with caregivers of patients diagnosed with GIC during chemotherapy therapy was done. The caregivers answered 2 questionnaires, SF-36 (Short Form Health Survey 36) and CBS (Caregiver Burden Scale). Results: 100 caregivers of 100 patients with GIC were included. The mean age of the patients was 62.2±13 years. Most of them had colorectal cancer (66%), ECOG 0-1 (87%) and stage II/III (81%) disease. Among caregivers, 81% had less than 60 years old and 76% were female. According to the SF-36, lower levels were observed in the emotional, physical aspects and vitality and the best average in functional capacity. Regarding the CBS instrument, the general strain domain and disappointment was the more affected. Stage or ECOG was not associated to the caregivers QOL or burden. High schooling level of the patients was associated with a better quality of life and less burden of the caregivers. Ageing caregivers had a worst QoL and an increased burden.Conclusion: Most of caregivers were women and youngers and had a worst quality of life in emotional role, physical aspects and vitality and an increased burden in general strain and disappointment.
AI-guided use of balanced PPARα/γ dual agonist finetunes macrophage responses in inflammatory bowel disease
Authors: Katkar Gajanan , Sayed Ibrahim , Anandachar Mahitha Shree , Castillo Vanessa , Eleadah Vidales , Toobian Daniel , Usmani Fatima , Sawires Joseph , Leriche Geoffray , Yang Jerry , Sandborn William , Das Soumita , Sahoo Debashis , Ghosh Pradipta 
Published: March 2021

Abstract
A computational platform, the Boolean network explorer (BoNE), has recently been developed to infuse AI-enhanced precision into drug discovery; it enables querying and navigating invariant Boolean Implication Networks of disease maps for prioritizing high-value targets. Here we used BoNE to query an Inflammatory Bowel Disease (IBD)-map and prioritize two nuclear receptors, PPARα/γ. Balanced agonism of PPARα/γ was predicted to impact macrophage processes, ameliorate colitis in network-prioritized animal models, ‘reset’ the gene expression network from disease to health, and achieve a favorable therapeutic index that tracked other FDA-approved targets. Predictions were validated using a balanced and potent PPARα/γ-dual agonist (PAR5359) in two pre-clinical murine models, i.e., Citrobacter rodentium-induced infectious colitis and DSS-induced colitis. Mechanistically, we show that such balanced dual agonism promotes bacterial clearance more efficiently than individual agonists both in vivo and in vitro; PPARα/γ is required and its agonism is sufficient to induce the pro-inflammatory cytokines and cellular ROS, which are essential for bacterial clearance and immunity, whereas PPARα/γ-agonism blunts these responses, delays microbial clearance and induces the anti-inflammatory cytokine, IL10. Balanced agonism achieved controlled inflammation while protecting the gut barrier and ‘reversal’ of the transcriptomic network. Furthermore, dual agonism effectively reversed the defective bacterial clearance observed in PBMCs derived from IBD patients. These findings not only deliver a macrophage modulator for use as barrier-protective therapy in IBD, but also highlight the potential of BoNE to accelerate and enhance the precision of drug discovery.
Accumulation, risk assessment of trace elements in soil-herbage systems and effects of elevation on subalpine grassland in the northeast of Tibet Plateau
Authors: Yang Qianfang , Wang Shengli , Zhao Cuicui , Nan Zhongren 
Published: March 2021

Abstract
Ecological environment of remote grassland has become increasingly serious in many countries due to mining, tourism, grazing and other human activities. In this study, a total of 15 pairs of soil-herbage samples were collected in the northeast of the Tibet Plateau to study the relationship between physicochemical properties and content of trace elements in soils and elevation, and to examine the accumulation and fractionation of heavy metals in soil-herbage systems. In addition, the ecological risk of the subalpine grassland was also assessed. The average concentrations of Hg, As, Cu, Zn, Pb, Cd, Cr and Mn in soil were higher than their background values of Gansu soil, but the average concentrations of these heavy metals in herbage satisfied Hygienical Standard for Feeds. The speciation analysis of heavy metals in soil indicated that the exchangeable content of heavy metal was very low, except Pb, Cd, Mn. There was a linear relationship between pH, CaCO3, total phosphorus (TP), organic matter (OM), concentrations of Hg, As, Zn, Pb, Cr and Mn in soils, dry weight of herbage and elevation, while there was a quadratic curve trend between Cu, Cd in soils and elevation. The results of risk assessment showed that there was no obvious ecological risk in the study area.