bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical usefulness of drug-laboratory test interaction alerts: a multicentre survey
Authors: van Balveren Jasmijn A. , Verboeket-van de Venne Wilhelmine P. H. G. , Doggen Carine J. M. , Cornelissen Anne S. , Erdem-Eraslan Lale , de Graaf Albert J. , Krabbe Johannes G. , Musson Ruben E. A. , Oosterhuis Wytze P. , de Rijke Yolanda B. , van der Sijs Heleen , Tintu Andrei N. , Verheul Rolf J. , Hoedemakers Rein M. J. , Kusters Ron 
Published: March 2021

Abstract

Objectives
Knowledge of possible drug-laboratory test interactions (DLTIs) is important for the interpretation of laboratory test results. Failure to recognize these interactions may lead to misinterpretation, a delayed or erroneous diagnosis, or unnecessary extra diagnostic tests or therapy, which may harm patients. The aim of this multicentre survey was to evaluate the clinical value of DLTI alerts.

Methods
A survey was designed with six predefined clinical cases selected from the clinical laboratory practice with a potential DLTI. Physicians from several departments, including internal medicine, cardiology, intensive care, surgery and geriatrics in six participating hospitals were recruited to fill in the survey. The survey addressed their knowledge of DLTIs, motivation to receive an alert and opinion on the potential influence on medical decision making.

Results
A total of 210 physicians completed the survey. Of these respondents 93% had a positive attitude towards receiving DLTI alerts; however, the reported value differed per case and per respondent’s background. In each clinical case, medical decision making was influenced as a consequence of the reported DLTI message (ranging from 3 to 45% of respondents per case).

Conclusions
In this multicentre survey, most physicians stated DLTI messages to be useful in laboratory test interpretation. Medical decision making was influenced by reporting DLTI alerts in each case. Alerts should be adjusted according to the needs and preferences of the receiving physicians.
DC-link current based position estimation and speed sensorless control of a BLDC motor used for electric vehicle applications
Authors: John Lionel Febin Daya , Jayan Jestin , Srinivasan Mohan Krishna , Prabhakaran Prajof 
Published: March 2021

Abstract
Sensors of any kind contribute to extra space and electronics when they are used in any application. Besides, the sensor noise also has the effect of altering the overall gain of the system. This is more prevalent in non-linear systems like motor control. In applications which have strict space constraints like Electric vehicles, the use of sensors must be optimized, which, in turn, gave rise to many sensorless state estimation strategies. This paper proposes a novel sensorless control technique for brushless direct current (BLDC) motor used in electric vehicle applications. The concept of sensorless control in BLDC Motor drive eliminates the hall-effect position sensor, thereby giving better performance and improves the robustness of the overall drive system. The main objective of this work is to estimate the position of the motor at standstill condition using stator saturation effect concerning the rotor, accelerate the motor from standstill so that enough back EMF is generated. This acceleration technique speeds up the motor to a stage where a self-actuating control mechanism is used to generate control signals with back EMF or line voltages. The motor can be started with a load, which is a significant constraint for electric vehicle application. The proposed method will avoid the reverse rotation of the motor. The proposed work is simulated in Matlab/Simulink software, and results obtained show that it works well under dynamic conditions of starting, acceleration and load switching. The hardware setup of the proposed work is developed using the TMS320F2812 DSP processor. Simulation and experimental results validate the effectiveness of the proposed work for electric vehicle application.
Pelvic pain correlates with peritoneal macrophage abundance not endometriosis
Authors: Gibson Douglas A , Collins Frances , De Leo Bianca , Horne Andrew W , Saunders Philippa T K 
Published: March 2021

Endometriosis is a chronic neuroinflammatory pain condition affecting ~180 million women worldwide. Surgical removal or hormonal suppression of endometriosis lesions only relieves pain symptoms in some women and symptomatic relapse following treatment is common. Identifying factors that contribute to pain is key to developing new therapies. We collected peritoneal fluid samples and clinical data from a cohort of women receiving diagnostic laparoscopy for suspected endometriosis (n = 52). Peritoneal fluid immune cells were analysed by flow cytometry and data compared with pain scores determined using the pain domain of the Endometriosis Health Profile Questionnaire (EHP-30) in order to investigate the association between peritoneal immune cells and pain symptoms. Pain scores were not different between women with or without endometriosis, nor did they differ according to disease stage; consistent with a poor association between disease presentation and pain symptoms. However, linear regression and correlation analysis demonstrated that peritoneal macrophage abundance correlated with the severity of pelvic pain. CD14high peritoneal macrophages negatively correlated with pain scores whereas CD14low peritoneal macrophages were positively correlated, independent of diagnostic outcome at laparoscopy. Stratification by pain subtype, rather than endometriosis diagnosis, resulted in the most robust correlation between pain and macrophage adundance. Pain score strongly correlated with CD14high (P = 0.007) and CD14low (P = 0.008) macrophages in patients with non-menstrual pain and also in patients who reported dysmennorhea (CD14high P = 0.021, CD14low P = 0.019) or dysparunia (CD14high P = 0.027, CD14low P = 0.031). These results provide new insight into the association between peritoneal macrophages and pelvic pain which may aid the identification of future therapeutic targets.

Lay summary
Endometriosis is a common condition where cells similar to those that line the womb are found elsewhere in the body. It is associated with inflammation and pain in the pelvis and affects ~180 million women worldwide. Current treatments are not effective for all patients and we, therefore, need to understand what causes pain in order to develop new treatments. We investigated the types of immune cells present within the pelvis of women undergoing investigation for suspected endometriosis. Disease diagnosis and stage (I–IV) was recorded along with pain score determined by questionnaire. We characterised the immune cells present and compared them to disease stage and pain score. We found that pelvic pain was linked to the abundance of immune cells but, surprisingly, not to disease stage. These findings suggest that immune cells are closely associated with pain severity in endometriosis and may be good targets for future endometriosis treatments.
Evaluating the effectiveness of using enoxaparin to prevent venous thromboembolism in hip replacement patients: A retrospective cohort study
Authors: Thanh Toan Vo , Dong Kha To , Van Anh Bui 
Published: March 2021

Introduction: Our research aims to evaluate the effectiveness of thromboprophylaxis using enoxaparin in patients undergoing hip replacement.
Methods: A retrospective cohort study was conducted based on medical records of patients aged 40 years and older undergoing hip replacement. Exclusion criteria included patients who had used anticoagulants to prevent other diseases, patients with a history of chronic renal failure, liver failure, cancer or allergy to anticoagulants, and patients with indicated mechanical prophylaxis. In our study, 65 patients were randomized into 2 groups - the control group and the venous thromboembolism (VTE) prophylaxis group (receiving subcutaneous enoxaparin 40 mg daily for 7 - 14 days). Preventive effectiveness was evaluated based on the comparison of VTE incidence after surgery between the groups.
Results: In our study, most of the patients were over 60 years old (79.2%). No case of pulmonary embolism was recorded. There were 11 patients in the control group (17.2%) who developed deep venous thrombosis (DVT) versus 2 patients in the prophylaxis group (3.1%). After adjusting for postoperative hospital stay, use of enoxaparin reduced the risk of DVT by 89.7% (OR 0.103, 95% confidence interval 0.019-0.569, p=0.009), especially in patients over 60 years old (OR 0.147, 95% confidence interval 0.026 - 0.822, p = 0.029).
Conclusion: This study demonstrates that using enoxaparin significantly reduces the incidence of DVT in patients undergoing hip replacement, especially in patients over 60 years old.
Variation in Management and Outcomes of Children With Complicated Pneumonia
Authors: Gross Caroline J. , Porter John J. , Lipsett Susan C. , Monuteaux Michael C. , Hirsch Alexander W. , Neuman Mark I. 
Published: March 2021

OBJECTIVES:To assess the characteristics of children hospitalized with complicated pneumonia at US children’s hospitals and compare these characteristics with those of children hospitalized with community-acquired pneumonia (CAP).METHODS:We identified children hospitalized with complicated pneumonia (parapneumonic effusion, empyema, necrotizing pneumonia, or lung abscess) or CAP across 34 hospitals between 2011 and 2019. We evaluated differences in patient characteristics, antibiotic selection, and outcomes between children with complicated pneumonia and CAP. We, also, assessed seasonal variability in the frequency of these 2 conditions and evaluated the prevalence of complicated pneumonia over the 9-year study period.RESULTS:Compared with children hospitalized with CAP (n = 75 702), children hospitalized with complicated pneumonia (n = 6402) were older (a median age of 6.1 vs 3.4 years; P &lt; .001), with 59.4% and 35.2% of patients ≥5 years of age, respectively. Patients with complicated pneumonia had higher rates of antibiotic therapy targeted against methicillin-resistant Staphylococcus aureus (46.3% vs 12.2%; P &lt; .001) and Pseudomonas (8.6% vs 6.7%; P &lt; .001), whereas differences in rates of coverage against mycoplasma were not clinically significant. Children with complicated pneumonia had a longer median hospital length of stay and higher rates of ICU admissions, mechanical ventilation, 30-day readmissions, and costs. Seasonal variation existed in both complicated pneumonia and CAP, with 42.7% and 46.0% of hospitalizations occurring during influenza season. The proportion of pneumonia hospitalizations due to complicated pneumonia increased over the study period (odds ratio 1.04, 95% confidence interval: 1.02–1.06).CONCLUSIONS:Complicated pneumonia more frequently occurs in older children and accounts for higher rates of resource use, compared to CAP.
Resource Use by Hospital Type for Frequent Inpatient Pediatric Conditions
Authors: Lopez Michelle A. , Yu Xian , Walder Annette , Kowalkowski Marc A. , Colvin Jeffrey D. , Raphael Jean L. 
Published: March 2021

BACKGROUND:Children’s hospitals (CHs) deliver care to underserved, critically ill, and medically complex patients. However, non-CHs care for the majority of children with frequently occurring conditions. In this study, we aimed to examine resource use across hospitals where children receive care for frequent inpatient conditions.METHODS:This was a cross-sectional, observational analysis of pediatric hospitalizations for 8 frequent inpatient conditions (pneumonia, asthma, bronchiolitis, mood disorders, appendicitis, epilepsy, skin and soft tissue infections, and fluid and electrolyte disorders) in the 2016 Kids’ Inpatient Database. Primary outcomes were median length of stay (LOS) and median total cost. The primary independent variable was hospital type: nonchildren’s, nonteaching; nonchildren’s, teaching (NCT); and freestanding CHs. Multivariable linear regression was used to assess differences in mean LOS and costs.RESULTS:There were 354 456 pediatric discharges for frequent inpatient conditions. NCT hospitals cared for more than one-half of all frequent inpatient conditions. CHs and NCT hospitals cared for the majority of patients with higher illness severity and medical complexity. After controlling for patient and hospital factors, discharges for frequent inpatient conditions at CHs had 0.48% longer mean LOS and 61% greater costs compared with NCT hospitals (P &lt; .01).CONCLUSIONS:CHs revealed higher estimated costs in caring for frequent inpatient conditions despite controlling for patient- and hospital-level factors but also cared for higher illness severity and medical complexity. Further research is warranted to explore whether we lack sufficient measures to control for patient-level factors and whether higher costs are justified by the specialized care at CHs.
Pesticide removal and efficiency of different types of granular activated carbon
Authors: Marton Michal , Ilavský Ján , Barloková Danka 
Published: March 2021

AbstractPesticides as one of the micro-pollutants present a great problem and threat to the environment and human health. They can infiltrate the sources of drinking water by application on the agricultural fields. This article is focused on Atrazine, Terbuthylazine and their metabolites. It is their complex structure that makes them hard to degrade naturally and, thus, water needs to be treated before safe using. Therefore, this article studies adsorption on the two granular activated carbons Filtrasorb 400 and Norit 1240 W. For the determination of the concentration liquid chromatography was used. In this article it is presented that Filtrasorb 400 efficiency (26–40% and 33–45% for atrazine and terbuthylazine respectively) is better than the efficiency of Norit 1240 W (9–27% and 10–24% for atrazine and terbuthylazine respectively).
Controlling the failure behavior of FRP-reinforced concrete elements
Authors: Sakr Aziz , Orbán Zoltán 
Published: March 2021

AbstractConcrete indeterminate flexural members represented by continuous beams reinforced with both fiber-reinforced polymers and steel bars in a way that allows for moment redistribution at failure are analyzed. The efficiency of introducing steel bars in the critical sections where plastic hinges are likely to form is evaluated in terms of reliability. Monte Carlo simulation and the concept of comparative reliability are both employed. Ultimately, the effect of different design parameters on the strength reduction factor is evaluated.
Application of rooftop solar panels with coolant natural circulation
Authors: Shapoval Stepan , Spodyniuk Nadiia , Zhelykh Vasyl , Shepitchak Volodymyr , Shapoval Pavlo 
Published: March 2021

AbstractIn line with the energy development strategy of Europe, it is necessary to implement energy efficient buildings, in which the external enclosures are converters of solar energy to thermal. Therefore, the purpose of the publication was the scientific substantiation and development of the solar heating system with the use of rooftop solar panels. Graphical and analytical dependences of the coefficient of thermal efficiency of the solar panel in heat supply system from the angles of solar radiation incoming and the density of the radiation flux were obtained. Analysis of the results showed that the coefficient of thermal efficiency of the solar panel without transparent coating with the placement of pipelines of the circulation circuit of the coolant over the heat absorber increases by 50%.
BAGAIMANA KESEJAHTERAAN SUPIR BIS TERGANTUNG DUKUNGAN KELUARGA?
Authors: Hamdi Muhammad Dudih Fadilah , Nurendah Gemala 
Published: March 2021

The purpose of this study was to examine the effect of family support perception on fatigue and subjective well-being of the bus drivers. The research method used was a quantitative research with 125 bus driver participants. The instrument were Perceived Social Support from family or PSS-Fa (Procidano Heller, 1983) to measure family support, Fatigue Measurement Scale or SPK to measure fatigue, Scale of Positive and Negative Experience (SPANE) instrument and Satisfaction With Life Scale (SWLS) to measure subjective well-being. Technique of data analysis was used simple regression. The results of this study indicated that family support affected fatigue with a significance level of 0.000; and family support influenced subjective well-being with significance level of 0.01
The Practicality of Teaching Materials on Types of Crab in the Mangrove Forest Area to Improve Critical Thinking Skills for Islamic High School Students
Authors: Fauzan Nahri , Soendjoto Mochamad Arief , Zaini Muhammad 
Published: March 2021

The crab is an organism that has pe a major role in the mangrove ecosystem. The preservation of the mangrove ecosystem cannot be separated from the roles and responsibilities of humans. This can be started by creating awareness and practicing thinking skills to provide solutions to various existing environmental problems. According to the results of the TIMSS study, the low scientific ability of Indonesian students, especially its implementation in the form of scientific literacy, has not shown a good improvement so that learning innovations are needed, one of which is the manufacture of environment-based teaching materials. The purpose of this study was to describe the practicality of the teaching materials "Crab Types in the Mangroves Area" in training students' critical thinking skills at MAN Tanah Laut. The type of research used is the Tessmer formative test. The research data were analyzed descriptively, practical data included the feasibility of using teaching material and student responses, indicating that the teaching materials developed were practical for use in learning and could improve the critical thinking skills of MA students.Abstrak Kepiting merupakan organisme yang memiliki peran besar dalam ekosistem mangrof. Kelestarian ekosistem mangrof tidak luput dari peran dan tanggung jawab manusia. Hal ini dapat dimulai dari menciptakan kesadaran dan melatih keterampilan berpikir agar dapat memberikan solusi-solusi dari berbagai permasalahan lingkungan yang ada. Hasil studi TIMSS menunjukkan rendahnya kemampuan sains siswa Indonesia terutama implementasinya dalam bentuk literasi sains belum menunjukkan adanya peningkatan yang baik sehingga diperlukan inovasi pembelajaran salah satunya dengan pembuatan bahan ajar berbasis lingkungan. Tujuan penelitian ini adalah untuk mendeskripsikan kepraktisan Bahan Ajar “Jenis Kepiting di Kawasan Mangrof” dalam melatihkan keterampilan berpikir kritis siswa MAN Tanah Laut. Jenis penelitian yang digunakan adalah uji formatif Tessmer. Data hasil penelitian dianalisis secara deskriptif, data kepraktisan meliputi kepraktisan penggunaan bahan ajar dan respon siswa, menunjukkan bahwa bahan ajar yang dikembangkan praktis untuk digunakan dalam pembelajaran dan dapat meningkatkan kemampuan berpikir kritis siswa MA.
UJI FREE DRAINING COLUMN LEACH MENGGUNAKAN VARIASI PERSENTASI MATERIAL PAF DAN NAF: STUDI KASUS OVERBURDEN TAMBANG BATUBARA
Authors: Novianti Yuniar Siska , Reza Muhammad , Fatmawati Evi , Ramanda Rully 
Published: March 2021

Karakterisasi batuan penutup/overburden diperlukan untuk mengetahui penggolongan batuan berpotensi membentuk asam atau tidak sehingga dapat memperediksi potensi pembentukan air asam tambang pada kegiatan penaambangan. Salah satu bentuk karakterisasi batuan tersebut adalah dengan melakukan uji kinetik ynag berupa free draining column leach test (FDCL), tujuan pengujian FDCL ini adalah untuk mengetahui reaktivitas mineral sulfida, oksidasi dan kualitas air lindian. Dalam pengujian FDCL ini sampel diberikan berdasarkan persentasi material PAF dan NAF yaitu, kombinasi pertama adalah 40:60, kombinasi pertama adalah 50:50 dan kombinasi ketiga adalah 60:40. Pengujian ini mengguanakan siklus basah-kering dan dilakukan selama 22 hari dalam siklus harian, dan melakukan pengujian air hasil lindian dengan parameter pH, TDS dan EC. Dari hasil pengujian didapatkan bahwa ketiga kombinasi untuk nilai TDS dan EC sudah menunjukkan korelasi yang positif karena berada didalam range nilai kualitas air normal sebesar 0.5, pH awal hasil uji statik untuk batuan PAF pada pengujian ini sebesar 2.31 dan pH untruk batuan NAFnya sebesar 6.49 sehingga untuk hasil lindian pada parameter pH hari pertama berada pada kisaran 3 - 3.5 kondisi ini pada ketiga kombinasi mengalami perubahan nilai pH menuju pH netral setiap waktunya, namun pada hari ke 22 kombinasi pertama dan ketiga mengalami penurunan hal ini besar kemungkinan reaktivitas mineral sulfida masih berlangsung dan laju pelapukan batuan juga masih berproses. Sehingga harapannya jika siklus penyiraman dilanjutkan untuk siklus mingguan dan bulanan proses reaktivitas minerl sulfida dan oksidasi dapat menunjukkan nilai yang konstan. Dan untuk kombinasi yang memiliki peningkatan nilai pH yang baik ditunjukkan pada kombinasi 2 dengan pH hari pertama air lindian sebesar 3.5 dan menjadi 4.7 pada hari keduapuluh dua pengujian. Keywords: PAF; NAF; Free draining column leach test
Pembelajaran Bagi Siswa Berkesulitan Belajar Matematika di Sekolah Dasar
Authors: Minsih Minsih , Yusa Pressilia , Hera Treny , Mujadid Imam 
Published: March 2021

Tujuan penelitian ini dilaksanakan untuk mendeskripsikan gangguan kesulitan belajar matematika yang dialami siswa kelas rendah di MI Muhammadiyah Gonilan Kartasura. Salah satu penyebab kesulitan belajar matematika yaitu penggunaan metode dan strategi yang masih konvensional. Guru masih menerapkan pembelajaran yang yang berorientasi pada guru yaitu ceramah dan penugasan. Karena itu, penggunaan metode pembelajaran yang tepat dan cenderung melibatkan siswa untuk berpartisipasi secara aktif sangat diperlukan agar mempermudah proses pembelajaran terutama siswa yang mengalami berkesulitan belajar. Subjek dari penelitian ini adalah peserta didik yang mengalami kesulitan belajar matematika di kelas rendah. Data yang dianalisis berdasarkan hasil observasi, wawancara, dan dokumentasi yang selanjutnya menggunakan validitas data triangulasi sumber dan teknik. Hasil menyatakana bahwa terdapat beberapa strategi guru dalam mengatasi kesulitan belajar peserta didik kelas rendah MI Muhammadiyah Gonilan Kartasura. Strategi yang dilakukan berupa; 1) Memberikan jam tambahan/pretest, 2) Program remidial, 3) Memonitor peserta didik secara khusus, 4) Menggunakan media pembelajaran, dan 5) Memberikan motivasi. Dari strategi tersebut, dapat membantu kesulitan belajar siswa kelas rendah yang menalami berkesulitan belajar pada pelajaran matematika.<p class="PageNumber1"> </p>
Evaluation of the effect of MTNR1B rs10830963 gene polymorphism on the therapeutic efficacy of nateglinide in treating type 2 diabetes among Chinese Han patients
Authors: Song Jin-Fang , Zhang Jie , Zhang Ming-Zhu , Ni Jiang , Wang Tao , Zhao Yi-Qing , Khan Naveed Ullah 
Published: March 2021

Abstract
Genetic polymorphisms in the MTNR1B gene is associated with type 2 diabetes mellitus (T2DM); however, there is no evidence about its impact on the therapeutic efficacy of nateglinide. This prospective case-control study was designed to investigate the effect of MTNR1B rs10830963 gene polymorphism on the therapeutic efficacy of nateglinide in treating T2DM. We genotyped untreated T2DM patients (N = 200) and healthy controls (N = 200) using the method of the high resolution of melting curve (HRM). Newly diagnosed T2DM patients (n = 60) with CYP2C9*1 and SLCO1B1 521TT genotypes were enrolled and given oral nateglinide (360 mg/d) for 8 weeks. The outcome was measured by collecting the venous blood samples before and at the 8th week of the treatment. The risk G allelic frequency of MTNR1B rs10830963 was higher in T2DM patients than the healthy subjects (P < 0.05). Post 8-week of treatment, newly diagnosed T2DM patients showed a less reduction in fasting plasma glucose levels and less increase in the carriers of genotype CG + GG at rs10830963 when compared with the CC genotype (P < 0.05). MTNR1B rs10830963 polymorphism was associated with the therapeutic efficacy of nateglinide in T2DM patients. Also, the CC homozygotes had a better effect than G allele carriers. Trial registration: Chinese Clinical Trial Register ChiCTR13003536, date of registration: May 14, 2013.