bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Antiepileptic Activity of Flowers of Cocos nucifera L. Against Experimentally Induced Convulsions in Rats
Authors: B Archana , Mudavath Ravi Naik , Enumula Vinay , Ravali N , Sravan Kumar Paka 
Published: December 2021

The report used to be planned to analyze the antiepileptic activity of Cocos nucifera flowers against special experimentally induced convulsions in rats. In the present study, antiepileptic activity was assessed by following experimental models. Anti-convulsant in vivo models: Maximal electroshocks (MES) induced models in rats, Pentylenetetrazole (PTZ) induced in rats. Pretreatment of animals with Cocos nucifera flowers extract has reduced by half the general continuance of tonic hind leg extension, the most commonly used endpoint in assessing clonic convulsions. MES provokes repetitive neuronal firing indicates epileptic neurons. MES is the widely accepted model to demonstrate the antiepileptic property of a drug. This property is antagonistic of the plant extract could flow from to blockade of voltage-gated sodium channel or due to effect on NMDA receptors. The Cocos nucifera flowers extract was also demonstrated potential anticonvulsant activity in PTZ induced convulsions and this may be due to its agonistic activity on the GABAA receptor. This is further supported by an elevated level of GABA by the plant extract in the PTZ model. Methanolic extract of Cocos nucifera flowers has shown significant anticonvulsant activity against MES and Pentlylenetetrazole induced convulsion models. This observed activity could also be the referable presence of flavonoids and other phytochemical constituents found in the powerful extract.
Keywords: Cocos nucifera, antiepileptic activity, Maximal electroshock, Pentlylenetetrazole, Flavonoids,
Formulation, Development and Evaluation of Bilayer Floating Tablets of Antihypertensive Drug Bosentan
Authors: Niranjan Abadhesh Kumar , Singh Alka 
Published: December 2021

Hypertension, or high blood pressure, is a major public health concern around the world because of its large contribution to the global health burden and its function as a major risk factor for a variety of disease processes. Bosentan SR Floating Bilayer Tablets were made with HPMC K4M, HPMC E-15, and HPMC E-15 alone (80%) and in combination with varying percentages of polymer (20&60 percent, 40&40 percent, and 60&20 percent ). The hydrophilic polymer HPMC is used to make three different formulations (M4, M8, and M12) of floating Bosentan SR tablets, each with a viscosity grade of 80 percent. M12 formulation was shown to be suitable for SR tablet formulation. From the M12 formulation. It's based on the M12 formula. The fraction of high viscosity polymer can be lowered by adding low viscosity polymer, as demonstrated in the C3 formulation. It was clear from the dissolution profile of formulation C3 that by mixing the low and high viscosity polymers, the drug release from the formulation may be improved as compared to manufacturing M12 high viscosity polymer alone. According to the findings of this investigation, as floating duration increases, the release rate drops. As a result, it's appropriate for long-term formulation.
Keywords: Bosentan, Floating Bilayer Tablets, Hypertension, SR Tablets, HPMC K4M, E-15
A review on medicinal plants as potential sources of natural immunomodulatory action
Authors: Porwal Omji , Ozdemir Mehmet , Kala Duran , Anwer Esra Tariq 
Published: December 2021

The concept of immunomodulation was proposed by Edward Jenner, while working on polio vaccine in 1796. A brawny, fine-functioning immune system is the keystone of excellent health. Immune replies are the consequence of an effectual interaction among innate (natural and non-specific) and acquired (adaptive and specific) components of the immune system. Inequity or failure of the immune systems is connected with a variety of chronic illness counting allergies, autoimmune diseases, cancers and furthers. Diverse innate and adaptive immune cells that are incorporated in this multifaceted networking organization may symbolize talented targets for expanding immunotherapeutics for treating specific immune illness. An assorted array of natural, synthetic, and recombinant compounds is accessible with both advantages and demerits. A range of phytochemicals have been remote, differentiated and customized for expansion and employ as avoidance or cure of human diseases, but the request of customary or novel medicinal plants for employ as immunomodulators in indulgencing immune diseases is still comparatively limited. At present, there is much-growing interest in the use of medicinal plants as modulators of the complex immune system. Numerous therapeutic consequences of plant extracts have been recommended to be because of their extensive assortment of immunomodulatory effects and persuade on the immune system of the human body. In present review paper, various medicinal plants, their resultant crude or fractionated phyto extracts and the precise phytochemicals remote from them are conversed in terms of their immunomodulatory bioactivities. We also review their possible for future expansion as immunomodulatory or inflammation-regulatory therapeutics or agents.
Keywords: Immunomodulation, Immune system, Phytochemicals, Medicinal plant, Plant extracts
A Review on medicinal plants in dentistry
Authors: Porwal Omji , Kala Duran 
Published: December 2021

The dental afflictions are indubitably the most important global infectious diseases affecting both children and adults. The most significant dental illness is dental caries and periodontal pathologies. The major reason of oral health troubles is more inhabitants with pathogenic bacteria and for this reason, conservative treatment can often be in efficient because of bacterial resistance or may have unpleasant side effects.For that reason, studies in the field have focused on finding new therapeutic alternatives.The use of natural medicines for dental care is an ancient cross-cultural practice that persists in the majority of cultures today.Over the past decade, interest in drugs derived from medicinal plants has markedly increased. This study was designed at a literature review focusing on studies investigating herbal drugs and their therapeutic application, mechanism of action, side effects, toxicities and probable drug interactions. A small number of studies were established to hold their rational employ in dentistry. Because there is a rising employ of phytotherapeutic agents in dentistry, additional studies are required to evaluate their safety and efficacy for clinical use.
Keywords: Herbal medicine, Oral health, Dentistry, Caries, Infections
Scalability of the Basic Care Model for Very Low Birth Weight Infants and Implementation Research Considerations
Authors: Daga Subhashchandra 
Published: December 2021

Objectives: To study the scalability of the rural hospital (RH) model of basic newborn care in a general hospital (GH) by including very low birth weight (VLBW) infants, and to assess the implementation aspects.
Study design: Observational
Settings: RH (1988-1992) and General Hospital, (GH) (2010-2013).
Subjects: VLBW infants with birth weight ranging from 1000 g to 1500 g.
Interventions: (1) RH: Basic care including warmth, feeding, antibiotics, and oxygen (2) GH: Basic plus circulatory care (2010-12), and continuous positive airway pressure (CPAP) support (2013). Mechanical ventilation and surfactant therapy were not available.
Main outcome measure: Mortality
Results: The cumulative mortality (38.5%) with basic neonatal care in the RH model declined to 26.6% at the GH with the addition of circulatory support and a “home-made” CPAP system.
Conclusions: The RH package may be scaled up by adding CPAP and circulatory support to reduce the mortality among VLBW infants. The RH model is scalable horizontally and vertically.
What is already known about this subject?

Implementation research constitutes a relatively new and underdeveloped field,
One of the facets of health system research is the implementation research.
Implementation research aims at bridging the gaps between knowledge and action.

What does this study add?

Tertiary care center can help in developing basic newborn care at a rural hospital.
The rural hospital model can be upscaled vertically as well as horizontally.
Addition of circulatory support and CPAP to basic newborn care can significantly lower neonatal mortality.

How might it impact on clinical practice in the foreseeable future?
The study may encourage tertiary care centers to facilitate the development of basic newborn care centers at the rural hospitals. These centers, in turn, can spread horizontally.
Thermal Protection of Newborns: The World Health Organization Guidelines Need to Include Clear and Feasible Options for Low-Resource Settings
Authors: Daga Subhashchandra 
Published: December 2021

Backgorund: Hypothermia in babies may increase mortality, directly or indirectly, by potentiating the effect of the other morbidities. Guidelines published by The World health organization (WHO) on newborn health (2015) may be inadequate to address the issue in a low-resource setting. To be relevant in such a context, they should be user-friendly for the trainers of health workers (HW) who may be responsible for interpreting the recommendations and training the HW.
Text: According to earlier guidelines (2013), ‘No randomized or quasi-randomized trial that evaluated the impact of keeping infants warm after discharge (hospital births) or after 24 hours (home births) was identified’. However, kangaroo mother care (KMC), a strong recommendation with moderate-quality evidence, and thermal protection are inseparable, as the most crucial component of KMC is skin-to-skin contact, which keeps a baby warm. A HW may be surprised when the guidelines or the basis change and, the move comes at a time when the earlier guidelines (1993) are just finding roots in patient care practices. Current guidelines are based on the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology, where randomized trials assume more importance. The guidelines recommend the following methods to keep infants warm after birth: KMC (strong recommendation, moderate-quality evidence), intermittent KMC (strong recommendation, moderate-quality evidence), and radiant warmers or incubators (strong recommendation, very low-quality evidence). The divergence between the evidence and the recommendations may be difficult for the HW to comprehend.
Conclusions: The guidelines for postnatal care need to be revisited and revised so that clear and feasible options for keeping infants warm in low-resource settings are offered. Besides KMC, warm rooms, heated mattresses, plastic wraps and Styrofoam boxes may be suggested.
What is already known about this subject?
• In the absence of a randomized or quasi-randomized trial that evaluated the impact of keeping infants warm, there are fewer options in a low-resource setting.
• They include Kangaroo mother care and incubators/radiant warmers.
What does this study add?
• Options that may not have been supported by randomized trials but have consistent results may be suggested.
• They include warm rooms, heated mattresses, plastic wraps and Styrofoam boxes.
• In future revisions, the level of evidence should be paired with the recommendations.
How might this impact on clinical practice or future developments?
The health worker may choose the most feasible option at home or at a facility.
Policy Initiation for Development of Slow Charging Station Infrastructure and E-rickshaw Vehicle Registration Process in India
Authors: Neelam Kishore Kumar 
Published: December 2021

This paper is to enclave, a policy initiation for development of slow charging station infrastructure and E-rickshaw vehicles registration process in India. EV’s (Electric Vehicles) as the new green nonpolluting vehicle for last mile connectivity within the city limits. At the E-rickshaw market a no of models available, but there is no study done for governing method, rules to follow and provision for charging infrastructure. E-rickshaw are being considered as a priority option towards sustainable development. These vehicles are the smart choice and encouraged as feeder system for last mile connectivity. E-rickshaw mode has been excluded from NMT (Non-motorized Transport) category and included in Motor Vehicles Act (2014) as special purpose battery operated vehicle. The main objective of the paper is to creating a space for building the charging infrastructure with different tariff and to setup governing rules for E-rickshaw operators.
PANDUAN KOMPOSISI DASAR TARI KREASI BERBASIS FLIP HTML5 TERINTEGRASI PLATFORM VIDEO ONLINE PADA PEMBELAJARAN SENI BUDAYA DI SMA
Authors: Irwansyah Irwansyah 
Published: December 2021

Penelitian ini bertujuan untuk memproduksi e-book berupa Panduan Komposisi Dasar Tari Kreasi berbasis Flip HTML5 terintegrasi platform video online yang valid dan praktis pada pembelajaran seni budaya di SMA. Penelitian ini menggunakan metode penelitian pengembangan (development of research) dengan model Rowntree yang terdiri dari 3 tahapan, yaitu perencanaan,pengembangan,dan tahap evaluasi.Untuk tahap evaluasi penelitian ini mengadopsi model evaluasi Tessmer yang terdiri dari 4 tahapan, yaitu: (1) expert review; (2) one to one; (3) small group evaluation; dan (4) field trial. Pengumpulan data menggunakan lembar review ahli dan angket tanggapan siswa. Hasil penelitian mengindikasikan bahwa uji kelayakan produk rata-rata memperoleh nilai 86,92% dan hasil uji coba kepraktisan produk memperoleh nilai 87,75%. Berdasarkan hasil penelitian dapat disimpulkan bahwa e-book berupa Panduan Komposisi Dasar Tari Kreasi berbasis Flip HTML5 terintegrasi platform video online sangat layak dan praktis digunakan dalam pembelajaran Seni Budaya di SMA.
Effect of soft skills and emotional intelligence of health-care professionals on burnout: a Lebanese cross-sectional study / Effekte von Soft Skills und emotionaler Intelligenz auf Burnout von Fachkräften im Gesundheitswesen: eine Querschnittsstudie aus dem Libanon
Authors: Semaan Micheline Sleiman , Bassil Jana Pierre Abdallah , Salameh Pascale 
Published: December 2021

Abstract

Objectives
The main objective of this study is to assess the effect of soft skills and emotional intelligence on burnout among health-care professionals in Lebanon.

Materials and methods
A cross-sectional study was conducted among health-care professionals working all over Lebanon for a period of 3 months starting from March till June 2021. In total, 324 out of 345 contacted health-care professionals responded. The survey was anonymous and administered via social networks as a link to an electronic form. The study included general sociodemographic questions and validated scales to measure emotional intelligence (Trait Meta-Mood Scale [TMMS-24]), burnout (Maslach Burnout Inventory for Health Services Survey [MBI-HSS]), and soft skills.

Results
Higher burnout was associated with lower soft skills (β = −0.137). Job satisfaction was negatively associated with burnout (β = −8.064). Nurses had higher burnout levels than dentists, radiologists, midwives, nutritionists, psychotherapists, and speech therapists (β = −4.595). Also, people working in Baalbek, Akkar, Beqaa, North and South had lower burnout levels compared to those working in Beirut (β = −9.015). As for emotional intelligence, no statistically significant association was found with burnout (P = 0.116).

Conclusion
This study showed that soft skills and emotional intelligence can affect job burnout. Additional research should be conducted in order to support our findings.
Study of load bearing capacity of an infinite sheet weakened by multiple collinear straight cracks with coalesced yield zones
Authors: Shekhar S. , Akhtar Naved , Hasan S. 
Published: December 2021

Abstract
This paper is concerned with the analytical solution of a multi-side damage problem. The objective is to investigate the load-bearing capacity of an infinite elastic-plastic plate weakened by three pairs of collinear straight cracks with coalesced yield zones. Stress intensity factors (SIFs) are obtained when yield zones are subjected to three different patterns of yield stress distribution, i. e., constant, linearly, and quadratically varying. Muskhelisvili's complex variable approach is applied for uncovering the solution to this problem. The problem is solved and analyzed rigorously based on Dugdale's hypothesis. The numerical results are deduced for the load-bearing capacity of the plate and yield zone lengths. These results are analyzed and demonstrated graphically for various mechanical loading conditions and different crack lengths.
Effect of graphite nanoplatelets on spark plasma sintered and conventionally sintered aluminum-based nanocomposites developed by powder metallurgy
Authors: Shrivastava Pankaj , Alam Syed Nasimul , Maity Taraknath , Biswas Krishanu 
Published: December 2021

Abstract
In this work, aluminum (Al)-based nanocomposites reinforced with graphite nanoplatelets (GnPs) have been fabricated by conventional sintering as well as spark plasma sintering (SPS) techniques, and their microstructure and mechanical properties have been studied. The powder metallurgy (PM) route has been adopted to fabricate the various Al–GnP nanocomposites. Characterization of the powder mixtures and the nanocomposites has been carried out through different characterization techniques, such as X-ray diffraction (XRD), scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), and Raman spectroscopy. Compressive strength, Young's modulus, density, and Vickers microhardness of the various nanocomposites have also been determined. The HRTEM results show the formation of nonstoichiometric Al4C3 nanoparticles – during both conventional sintering and SPS – at the interface of the Al grains and GnP, which worsen the mechanical properties of the nanocomposites. SPSed nanocomposites show superior mechanical properties due to higher densification, finer grain size, and homogeneous nanofiller dispersion in the Al matrix, compared to the conventionally sintered Al–GnP nanocomposites.
Solidification microstructure in a supercooled binary alloy
Authors: Wang Hongfu , Tang Cheng , An Hongen , Zhao Yuhong 
Published: December 2021

Abstract
The maximum undercooling that has been achieved for Ni-Cu alloy, by using molten glass purification and cyclic super-heating technology, is 270 K. With the help of high-speed photography, the solidification front images of Ni-Cu alloy at various typical undercooling were obtained. Two grain refinements occurred in the range of 60 K< ΔT < 100 K and ΔT > 170 K, the solidification front became smoother, and the solidification position appeared randomly. With the increase of undercooling, the transition from solute diffusion to thermal diffusion leads to the transition from coarse dendrite to directional fine dendrite. At large undercooling, considerable stress is accumulated and some dislocations exist in the microstructure. However, the proportion of high-angle grain boundaries is as high as 89%, with twin boundaries of 13.6% and most strain-free structures, and the microhardness decreases sharply. This indicates that the accumulated stress at large undercooling causes the plastic strains in the microstructure, and in the later stage of recalescence, part of the plastic strains is dissipated by the system and acts as the driving force to promote the recrystallization of the microstructure.
Rhizomatic Assemblages: Connecting Climate Change to Nursing Action
Authors: Vold Lindsey , Meszaros Megan 
Published: December 2021

Calls for nursing action to address climate change are resounding throughout the nursing community, yet many nurses feel ill-prepared to engage in climate action. As a collective practice discipline, we argue that nursings’ internalized a rigid view of what nursing is and, through self-disciplining practices, actively police our knowledge and practice to conform within a bounded domain that fails to view global issues, such as climate change, as being within the scope of nursing. To build nurses’ climate action capacity, we draw on Deleuze and Guarttari’s (1987) concept of rhizomatic assemblages to make an explicit connection between health and climate change, but also how climate action is a moral imperative in the scope of nursing education and practice. Using examples in the four domains of nursing - education, practice, research, and policy, we present how nurses can engage in coordinated and collaborative efforts both within and outside of ‘traditional’ nursing practice to address the connecting and complicated pathways of a changing climate.
Kniphofia foliosa Hochst, (Asphodelaceae)
Authors: Aladejana Elizabeth Bosede , Musara Collen 
Published: December 2021

This review gives the first comprehensive appraisal of Kniphofia foliosa Hochst, from the plant family Asphodelaceae: its botany, ethnomedicinal (with particular emphasis on the African communities), phytochemistry, and pharmacological potential. Particular emphasis is given to the biological and chemical properties. Peer review and literature search were done by conducting a logical and inclusive review. Indigenous cultures have used the plant among different ethnic groups in tropical Africa for medicinal and other purposes. The chemical compounds that have been isolated from K. foliosa include monomeric anthraquinones such as chrysophanol, islandicin, laccaic acid, aloe-emodin, and aloe-emodin acetate, which contain antileukaemic properties; dimeric anthraquinones such as asphodelin, knipholone, and chryslandicin; phenyl anthraquinones and anthrones, including knipholone anthrone, isoknipholone anthrone, knipholone, phenylanthrone knipholone anthrone and anthraquinone isoknipholone; oxanthrones such as isofoliosone and foliosone; and rare dimeric phenylanthraqunones joziknipholones A and B. The pharmacological studies on K. foliosa exhibited antimalarial, antioxidant, antibacterial, anti-HIV-1, and anti-leukotriene activities. From the above, it can be deduced that K. foliosa contains chemical constituents of pharmacological importance, contributing significantly to the development of new medicines.
Therapeutic Effectiveness of Cefoperazone for Community-Acquired Pneumonia and Associated Factors in a Tertiary Care Hospital, Vietnam
Authors: Le Cua Ngoc , Nguyen Duong Trung , Kaewsawat Supreecha , Suwangbamrung Charuai , Khammaneechan Patthanasak 
Published: December 2021

Purpose: This study aimed to (i) identify the pathogenic bacterial profile and Cefoperazone (CPZ) sensitivity; (ii) assess the therapeutic effectiveness of CPZ and (iii) determine factors associating with the treatment success.
Patients and methods: The retrospective study was conducted in Kien Giang hospital, Vietnam. Sample size was 210 medical records of community-acquired pneumonia (CAP) patients admitted to the hospital from January to December 2018. The Chi square and Fisher’s exact test were used to determine factors associating with the treatment success such as age, gender, comorbidities, levels of CAP severity respiratory rate, PaO2, and laboratory findings of blood tests. Statistical significance was at level α = 0.05.
Results: The main pathogenic bacteria were Klebsiella pneumoniae (29.1%), Streptococcus pneumoniae (26.7%) and Pseudomonas aeruginosa (14%), and were highly susceptible to CPZ. Mean duration of obtaining clinical stability was 3.01 days. The obtainment of clinical stability through CPZ monotherapy on the third, fifth and seventh day of treatment process accounted for 78.9%, 87.6% and 100% of total cases, respectively. CPZ achieved a highly successful rate in the monotherapy (79.07%) if the treatment was guided by antibiotic sensitivity testing results. The association between the treatment success and factors such as age, respiratory rate, and severity category of CAP were statistically significant (p<0.05).
Conclusion: Minimizing CPZ resistance, and CPZ overuse during CAP therapy is necessary. The factors associating with the success of therapy are useful in predicting the prognosis of CAP patients, planning the sequential therapy, and determining hospital discharge.