bluuebunny/crossref_metadata_2025_split huggingface dataset:
VITAMIN D DEFICIENCY IN PATIENTS WITH PSORIASIS AND PSORIATIC ARTHRITIS
Authors: Q MOHAMMED JINAN , MATHKHOR ABDULSATAR J , S KHUDHAIRY AMER 
Published: January 2021

Objective: The objective of this study is to investigate the association between Vitamin D level and psoriasis, in particular in our city of the long, hot, and sunny weather, in an attempt to add a clarification to this controversial subject.
Methods: A case–control study included 120 patients with psoriasis and 38 patients with psoriatic arthritis (PsA); 89 (56.3%) patients were male. Psoriasis area and severity index (PASI) was calculated for all patients with psoriasis and disease activity score using 28 joints (DAS28) and erythrocyte sedimentation rate (DAS28) was measured for all patients with PsA. The control group comprised 164 age- and sex-matched participants (91 males and 73 females). Vitamin D serum level was performed for both patients and controls.
Results: Vitamin D levels in both patients and controls were 17.4±7.7 and 28.3±5.6, respectively. The level of Vitamin D was lower in a patient with disease duration equal and more than 10 years than those with a disease duration <10 years. There is no significant difference in Vitamin D levels between the two patient subgroups. Lower Vitamin D levels were associated with high PASI and high DAS28 in psoriasis and PsA, respectively.
Conclusion: Patients with psoriasis and PsA associated with low levels of serum Vitamin D. Vitamin D deficiency was found to be associated with long disease duration in both psoriasis and PsA. Patients with active disease have lower Vitamin D levels.
STUDY OF THE ANXIOLYTIC ACTIVITY OF ETHANOLIC EXTRACT OF ROOT OF ACORUS CALAMUS IN ALBINO MICE
Authors: KAUSHIK SHIPRA , KAUSHIK SHOBHIT 
Published: January 2021

Objective: Anxiety is classified as a form of sub-acute or chronic fear. Root of Acorus calamus has been traditionally used as an anxiolytic. The aim of the study is to assess the anxiolytic activity of ethanolic extract of A. calamus (EEAC) by elevated plus-maze test on Albino mice.
Methods: Albino mice of either sex were taken and divided into five groups, each consisting of 5 mice. One group was used as control, one as standard (diazepam), and three as test groups treated with 100, 200, and 400 mg/kg of EEAC. The drugs, that is, 10 ml/kg of normal saline for control, diazepam 2 mg/kg (standard), and 100, 200, and 400 mg/kg EEAC (test groups) were injected intraperitoneally (i.p.), 30 min before placing them in the center of the maze. The preferences of the animal to open/enclosed arm, average time spent in open arm, and numbers of entries in open arm were compared in each group. Data were statistically analyzed by one-way analysis of variance followed by multiple Dunnett’s test.
Results: The number of entries in open arm and the average time spent in the open arm by the mice is increased by EEAC in a dose-dependent manner.
Conclusion: EEAC has anxiolytic activity.
AMPHOTERICIN B TOPICAL EXTEMPORANEOUS PREPARATIONS FOR THE TREATMENT OF NON-DERMATOPHYTIC ONYCHOMYCOSIS
Authors: PHOJANA KOMESMUNEEBORIRAK , PORNPEN WERAWATGANONE , WALAISIRI MUANGSIRI 
Published: January 2021

Objective: At present, the nail preparation to cure onychomycosis, caused by non-dermatophyte molds, is not commercially available in Thailand. The physical and chemical stability of amphotericin B (AmB) extemporaneous preparations in the presence of 30% dimethyl sulfoxide (DMSO) and their in vitro nail permeation was evaluated.
Methods: AmB extemporaneous preparations in the presence of 30% DMSO were prepared from a commercial sterile injection product, and cream or hydrophilic ointment. Physical stability was tested at 30°C for 2 months, or using 6 heating-cooling cycles. The chemical stability and in vitro nail permeation of AmB content were analyzed using high-performance liquid chromatography (HPLC). In vitro nail permeation was performed by applying 3.5 mg/mm2 of the tested formulation on nail clippings for 5 consecutive days.
Results: The AmB cream and ointment extemporaneous preparations containing 30% DMSO, a permeation enhancer, were homogeneous and pale yellow to yellow cream or ointment. The AmB ointment was stable for up to 60 days. The ointment preparation allows in vitro penetration through nails up to 14.17 μg/cm2. The ointment preparation allows significantly better penetration through than the cream preparation due to the presence of DMSO, sodium lauryl sulfate (SLS), and water in the ointment preparation.
Conclusion: The AmB extemporaneous ointment was successfully compounded from a commercial sterile injection product with a beyond-use date of 60 days. The ointment preparation is currently under further investigation for in vivo efficacy.
ANTIFUNGAL AND ANTIBIOFILM ACTIVITY OF 2-BROMO-N-PHENYLCETAMIDE AGAINST CRYPTOCOCCUS NEOFORMANS
Authors: DE MELO THAMARA RODRIGUES , CORDEIRO LAÍSA VILAR , DA SILVA SOUZA HELIVALDO DIÓGENES , DE ATHAYDE-FILHO PETRÔNIO FILGUEIRAS , DE OLIVEIRA-FILHO ABRAHÃO ALVES , FERREIRA SÁVIO BENVINDO , OLIVERIA LIMA EDELTRUDES DE 
Published: January 2021

Objective: This study aimed to evaluate the antifungal and antibiofilm of 2-bromo-N-phenylacetamide (A1Br) against Cryptococcus neoformans in vitro.
Methods: The compound was characterized by infrared and 1H-nuclear magnetic resonance spectrometry data. Minimum inhibitory concentration (MIC) was determined using the plate dilution method and biofilm formation inhibition of the crystal violet assay.
Results: A1Br inhibited the growth of C. neoformans with MIC of 0.25 and 0.5 μg/ml and has good antibiofilm activity MIC ×4, with ≥80% inhibition growth.
Conclusions: Thus, A1Br shows potential antifungal and antibiofilm agents for the treatment of infections caused by C. neoformans, as well as the eradication of cryptococcal colonization of medical prosthetic devices.
AN OBSERVATIONAL STUDY OF ENTHESOPATHY IN DRIED HUMAN SCAPULAE
Authors: AGARWAL SUMITA , MOTAGI MANJUNATH V , PAL VISHNU , VAIDYA YUGANTI 
Published: January 2021

Objectives: An abnormal ossification process in soft tissues at the attachment site to a bone is called enthesopathy due to biomechanical movements of bone. The present study aimed to observe the calcification of the transverse scapular ligament (TSL) with complete or partial ossification, the presence of the triangular bony growth at the lateral border of scapula and to observe vascular foramen/foramina piercing at the bases of the spine of scapulae.
Methods: An observational study was conducted on dried human scapulae 140 in number (70 right and 70 left) of unknown sex and age, procured from the Department of Anatomy, People’s College of Medical Science and Research Center, Bhopal, and Government Doon Medical College, Dehradun, India. These scapulae were studied to observe enthesopathic changes in them. Measurements were taken with Vernier calipers.
Results: In the present study, we observed the presence of completely ossified TSL with formation of complete suprascapular foramina in 8.57% scapulae. The incidence of triangular bony growth at the lateral border of scapula was found in 40% scapulae of the right side and 32.85% of the left. The incidence of vascular foramina piercing at the bases of the spine of scapulae was 17.14% on the right side and 21.42% on the left side scapulae.
Conclusion: The study provides the descriptive knowledge of enthesopathy in scapulae. The study is of great significance for neurosurgeons and orthosurgeons to carry out various reconstructive surgeries.
Past Decade Work Done on Cubosomes and its Factorial Design: A Fast Track Information for Researchers
Authors: Shravani Y  , Hindustan Abdul Ahad  , Chinthaginjala  Haranath  , Bhumireddy  gari Poojitha  , Syed Rahamathulla  , Aswarthanarayana Rupasree  
Published: January 2021

The objective of this review is to explore the past work done on Cubosomes as drug delivery systems by factorial design. Cubosomes are Nanoparticulate systems made of amphiphilic lipids at a certain percentage, known as liquid crystals. They have tightly packed honeycomb structures twisted into 3D bilayers. Cubosomes can capture all categories of the lipophilic, hydrophilic, and amphiphilic substances irrespective of their affinity, by that they fit for delivering all range of drugs with ease. Many works in recent days are concentrating on Cubosomes for drug delivery, as it suits all ranges of drugs without much difficulty. Cubosomes acts as a carrier in drug delivery for a wide range of drugs and protects them from degradation issues like hydrolysis, oxidation, and others. Moreover, numerous studies have established the benefits of Cubosomes in nanotechnology, prolonged-release, and also enhanced bioavailability. This article reviews about the past work done on Cubosomes using factorial design. Additionally, many studies need to be performed for the optimization of Cubosomes for artificial cells, and biosensors, etc. Moreover, the rational design of Cubosomes for biomedical applications need to be developed. A widespread literature assessment revealed that many reviews and research attempts were made on Cubosomes, but no review article is still available in bringing the attempts made on Cubosomes by factorial design on a single platform. The factorial approach is used to optimize the formulation, which is acceptable and used in the current scenario in optimizing the formulations. So, the authors made widespread work by referring to peer-review journals, periodicals, magazines, and succeeded in bringing work done on Cubosomes in the last ten years by using factorial design. The study concludes and gives a quick reference to the young researchers to get literature on earlier successive attempts done on Cubosomes by factorial design.
Mediação da informação e suas dimensões dialógica, estética, formativa, ética e política: um fundamento da Ciência da Informação em favor do protagonismo social
Authors: Gomes Henriette Ferreira 
Published: January 2021

Estudo analítico da literatura científica que focaliza o fenômeno informação, a mediação da informação, teorias sóciointeracionistas,articulando abordagens de autores que situam a informação e o fazer informacional em uma perspectivasocial em diálogo com abordagens que focalizam a mediação da informação, as teorias sócio-interacionistas, teorias dacomunicação, semióticas e linguísticas, com o apoio da técnica da análise de conteúdo em leituras intensivas e recursivasna identificação de pontos de convergência entre as perspectivas e proposições. Como resultado amplia as dimensõesda mediação da informação, apresentando uma proposição conceitual de informação e discutindo que a efetividade daação mediadora depende da mediação consciente, que busca alcançar suas dimensões dialógica, estética, formativa,ética e política, assegurando o processo de problematização para que ocorra a apropriação da informação e a tomadade consciência, o que contribui para o desenvolvimento e fortalecimento do protagonismo social e permita o acesso,uso e a apropriação da informação em parâmetros democráticos, o que é fundamental ao processo de transformaçõessociais. Nessa perspectiva, ressalta a problematização e a práxis como categorias freirianas que sustentam a importânciada mediação consciente, a formação do profissional e intelectual orgânico do campo, assim como a proposição de se alçara mediação da informação e suas dimensões à condição de fundamento da Ciência da Informação.
Palavras-chave: Dimensões da mediação da informação. Mediação consciente da informação. Informação – Conceito.
Periódicos científicos brasileiros indexados no Google Scholar Metrics
Authors: Pinto Adilson Luiz , Do Canto Fabio Lorensi , Gavron Edson Mario , Talau Marcos 
Published: January 2021

Este trabalho tem o objetivo de identificar quantos periódicos científicos brasileiros são indexados pelo GoogleScholar Metrics e o de descrever as características das publicações. As variáveis analisadas são o escopo temáticoe o impacto (índice e mediana h5), a classificação Qualis, os idiomas do conteúdo, a periodicidade e a vinculaçãoinstitucional. Foram recuperados dados de 1.906 periódicos científicos brasileiros contidos no UlrichsWeb.Foi desenvolvido um script para busca e extração automatizada dos dados no sistema. Para os títulos nãoencontrados foi realizada uma busca manual. Foram identificados 1.063 periódicos brasileiros no Google ScholarMetrics, que correspondem a 55% do total pesquisado. Constatou-se que 33% das publicações são de CiênciasHumanas, 17% de Ciências da Saúde e Medicina e 17% de Ciências Sociais; os periódicos com maior média doíndice h5 são Ciências da Saúde (11,34) e Ciências Agrarias e Biológicas (9,11) e aproximadamente 90% do totalde publicações possuí índice h5 inferior a 10. Verificou-se ainda que aproximadamente 50% dos periódicos émantido por universidades públicas federais ou estaduais, 54% publica conteúdo somente em português e 65%é semestral ou trimestral. Pode-se afirmar que o Google Scholar Metrics é uma fonte relevante de análise deimpacto de periódicos brasileiros, principalmente de publicações acadêmicas, das áreas de Ciências Humanas eSociais e sem outro indicador de impacto. No entanto, o uso desse sistema para fins avaliativos oficiais deve serrealizado com cautela, considerando que o sistema apresenta inconsistências e limitações.
Palavras-chave: Google Scholar Metrics. Periódicos científicos brasileiros. Índice h5.
Fontes de informação sobre Gestão de Dados de Pesquisa
Authors: Cunha Murilo Bastos da , Costa Maira Murrieta 
Published: January 2021

O artigo apresenta uma bibliografia seletiva e anotada sobre as principais fontes de informação necessárias ao estudo da gestão de dados de pesquisa. Ela está dividida em duas partes; a primeira arrola os livros e manuais e os documentos gerais. Na segunda parte foram listados os documentos relacionados ao fluxo dos dados de pesquisa: políticas de gestão, planos para a gestão de dados, requisitos das agências de fomento, normas e padrões, metadados, fluxos de trabalho, aspectos legais, aspectos econômicos, compartilhamento e reuso de dados, preservação de dados, identificadores dos dados, citação de dados, visualização de dados, usuários de dados e avaliação dos sistemas.
Palavras-chave: Bibliografia. Gestão de dados de pesquisa. Preservação digital
A missão da Ciência da Informação na Era da Pós-Verdade
Authors: Araújo Carlos Alberto Ávila 
Published: January 2021

Neste texto são apresentados e discutidos alguns aspectos da realidade informacional contemporânea, marcada pelas questões da pós-verdade e da desinformação. Discute-se o potencial da ciência da informação para estudar e propor ações relacionadas com essa realidade, a partir dos três modelos de estudo existentes na área: o físico, o cognitivo e o social. Identifica-se a necessidade, a partir da noção de conhecimento e ignorância de Edgar Morin, de se promover um avanço na ciência da informação em direção a uma dimensão veritística, tal como formulado por Jonathan Furner. Conclui-se, a partir das ideias de Theodor Adorno, que a ciência da informação atual precisa ter como centro de sua missão a questão da verdade e do combate à circulação de informações falsas.
Palavras-chave: Pós-verdade. Desinformação. Ciência da informação. Epistemologia da ciência da informação.
Democracia documentária e Teoria da Não-conceitualidade: filosofia e práxis
Authors: Saldanha Gustavo 
Published: January 2021

O objetivo desta pesquisa é discutir a construção das possibilidades de problematizar a teoria da não-conceitualidade naCiência da Informação no âmbito da organização do conhecimento, com vistas a desenvolver uma abordagem políticocríticada democracia documentária. Por meio da abordagem metodológica da filosofia da linguagem ordinária, a pesquisaintegra a logologia de Bárbara Cassin, a teoria política de Maria Nélida González de Gómez e a teoria do conceito de EmanueleTesauro. Os resultados colocam em diálogo a organização ordinária dos saberes socialmente oprimidos e a Constituiçãobrasileira, estabelecendo a práxis documental como forma de luta e resistência na sociedade democrática.
Palavras-chave: Democracia documentária. Teoria da não conceitualidade. Organização ordinária dos saberes socialmenteoprimidos. Teoria do conceit. Logologia.
Mediação da leitura e alteridade na Educação Literária
Authors: Cavalcante Lidia Eugenia 
Published: January 2021

Discute a mediação da leitura na perspectiva da educação literária a partir da compreensão do conceito de alteridade. Tomacomo referência conceitual os estudos filosóficos de Emmanuel Lévinas e Paul Ricoeur acerca da alteridade. Apresenta comoquestão de pesquisa: qual o lugar da alteridade na mediação da leitura na educação literária contemporânea, nesses temposdifíceis de individualismo, isolamento, silenciamento e de subtração de direitos? Discute as implicações da mediação daleitura levando-se em consideração as subjetividades do leitor em relação ao texto e às linguagens. Busca compreendercomo a ação pedagógica na educação literária pode contribuir no que concerne à dialogicidade das experiências de cadaser humano. Conclui que o ato de ler pode contribuir para o desenvolvimento de saberes reflexivos e críticos que alicerçama construção do conhecimento, gerando modos de resistência às visões totalitárias, centralizadoras e assimétricas queteimam em reduzir os direitos humanos e a autonomia dos sujeitos. A leitura, portanto, pode propor outro caminho pormeio da linguagem e da cultura, não subordinada às formas de dominação.
Palavras-chave: Educação literária. Mediação de leitura. Alteridade.
The role of cardioenzymes in the diagnostics of infectious heart diseases
Authors: Babachenko I. V. , Sharipova E. V. , Alekseeva L. A. , Chuprova S. N. , Bessonova T. V. , Konstantinova Yu. E. 
Published: January 2021

Purpose: to evaluate the importance of increasing cardioenzymes in the diagnosis of infectious heart lesions.Object and methods: Under observation were 71 children aged 3 to 17 years (average age – 6.6 ± 0.4 years) who received treatment at the clinic of Pediatric Research and Clinical Center for Infectious Diseases. All children in the acute period of illness and 49 patients with follow-up history were identified with levels of creatine phosphokinase (CPK), MВ fractions of creatine phosphokinase (CPK-MВ), lactate dehydrogenase (LDH), C-reactive protein (CRP), aspartate aminotransferase (AST). Follow-up observation and examination of patients was performed after 1 month and after 1 year. All children were examined for a wide range of pathogens of acute respiratory viral infections, active herpes virus infections (EBV, CMV, HHV-6 type), B19 parvovirus, Chlamydophila pneumoniae, Mycoplasma pneumonia, enteroviruses and bacterial respiratory pathogens. All examined patients underwent electrocardiography and echocardiography.The results of the study. In the examined patients with an increased level of “cardioenzymes” (CPK-MВ, LDH, AST) against the background of acute respiratory infection (ARI), a wide range of diseases was established with damage to both the upper respiratory tract and lower (bronchitis, bronchiolitis, pneumonia), and also other infectious nosologies, including respiratory syndrome (infectious mononucleosis, enterovirus and parvovirus infection). The etiological structure was dominated by a group of herpesvirus (53%) and bacterial infections (25%), as well as their combinations. An analysis of the dynamics of the main biochemical and hematological parameters characterizing the severity of the systemic inflammation syndrome (leukocytes, SRE, CRP, CPK), as well as reflecting myocardial injuries and used in cardiology practice (CPK- MВ, LDH, AST), revealed a long-term (within 1 year observations) the preservation of a moderately elevated level of CPK-MВ, unlike other indicators that returned to normal within 1 month. An increase in CPK-MВ was recorded in 79% of patients with drip infections, while the average level of CPK-MВ in the total sample exceeded the normal values by 1.8-2.4 times.Conclusion. It was found that elevated levels of CPK-MВ and LDH can be used as criteria for the formation of dynamic observation groups and early rehabilitation.
Frequency of infectious complications and features of systemic inflammatory response in patients with prolonged disorders of consciousness
Authors: Dryagina N. V. , Kondratyeva E. A. , Kondratyev S. A. , Markovkina I. A. , Potemkina E. G. , Kondratyev A. N. 
Published: January 2021

Objective: investigate epidemiology of infectious complications, intensity of antibacterial therapy, and features of the systemic inflammatory response in patients with prolonged disorders of consciousness.Materials and methods: retrospective case histories analysis of 102 patients with prolonged disorders of consciousness who were treated in the department of anesthesiology and intensive care of Polenov Neurosurgical Institute from 2010 to 2019.Results: during hospitalization all patients (100%) had signs of tracheobronchitis, 86 patients (84,3%) had urinary tract infection, 34 (33,3%) pneumonia, 10 patients (9,8%) meningoventriculitis, and in 9 (8,8%) cases sepsis was diagnosed. Identified bacterial complications required systemic antibacterial therapy. With an average length of hospital stay of 51±42 days, duration of antibiotic therapy was 37±41 days. One-component therapy was applied in half of the cases (54%), slightly less often (43,2%) treatment consisted of two antibiotics, in some cases patient’s condition required prescription of three antibiotics (2,8%). Even in the absence of a focus of infection, temperature and laboratory markers of inflammation in blood samples of patients with prolonged disorders of consciousness were higher than the reference values. CRP was increased with addition of any bacterial complications. Count of white blood cells significantly increased only in case of pneumonia and sepsis. Procalcitonin test was positive in 16,6% observations of urinary tract infection, 30,4% of pneumonia, and 28% of meningoventriculitis.Conclusion: most informative proinflammatory marker of bacterial complications in patients with prolonged disorders of consciousness was CRP. Mild leukocyte response can be explained by immunosuppression in long-term ill patients. Limited value of procalcitonin test may be due to the insufficiency of the semi-quantitative method sensitivity with a threshold level of 0,5 ng/ml, as well as reduced proinflammatory response to local infection in patients with prolonged disorders of consciousness as a result of massive antibacterial therapy, colonization of opportunistic microflora and presence of sympathicotonia (non-infectious systemic inflammatory reaction).