bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient Centered Studies Focused on Type 2 Diabetes Management, Education,
and Family Support: A Scoping Review
Authors: Rosenthal Meagen , Arnold Austin , Salkar Monika , Patelb Sahil , Harrell Emily , Aldridge Harleigh , Mancuso Blake 
Published: November 2021

Background:
Although a large amount of research has been conducted in diabetes management,
many of the articles do not focus on patient-centered questions and concerns. To address
this shortcoming, patients and various other stakeholders from three northern Mississippi communities
co-created research questions focused on Type 2 diabetes management.

Objective:
To identify the diabetes management literature pertaining to each of the six patient-developed
research questions from March 2010 to July 2020.

Methods:
A scoping review was conducted via PubMed to identify research articles from March
2010 to July 2020 focused on patient-centered Type 2 diabetes studies relevant to the six research
questions.

Results:
A total of 1,414 studies were identified via the search strategy and 34 were included for
qualitative analysis following article exclusion. For one of the research questions, there were no articles
included. For the remaining research questions, the number of articles identified ranged from
two to eleven. After analysis of the included articles, it was found that these questions either lacked
extensive data or had not been implemented in the practice of diabetes management.

Conclusion:
v
Effects of Smokeless Tobacco Samples from Tabuk Saudi Arabia on Nitric
Oxide Production: A Potential Risk for Cancer and Cardiovascular Diseases
Authors: Jabeen Almas , Mesaik Muhammed Ahmed , Saeed Maria , Zaheer Ul-Haq  , Ahmed Izzaddinn Elawad , Ibrahim Mohammed Yassin , Mirghani Hyder Osman , Khalid Asaad 
Published: November 2021

Background:
Smokeless tobacco (SLT) is traditionally used in Middle East countries.
The several toxic constituents with potential carcinogenicity make it a serious human health risk.
Literature regarding their effects on cardiac and cancer disease is lacking in Saudi Arabia.

Objective:
This study was conducted to investigate the adverse effect of 11 different samples of
widely used SLT varieties from the Tabuk region - Saudi Arabia, on Nitric Oxide (NO) level and
their potential risk on cardiovascular health, etiology and/or progression of cancers.

Methods:
Samples were collected from Tabuk, KSA and analyzed by the GC-MS technique. Nitric
oxide inhibition was performed using J774.2 macrophages by the Griess method. The retrieved
crystallized structure of human inducible nitric oxide synthase (iNOS) from Brookhaven Protein
Data Bank Repository PDB I.D: 3E7G with 2.20Å resolution was further prepared by structure using
the MOE.2019 tool. The compounds abstracted from 11 different Shammah varieties were
sketched by the MOE-Builder tool. Minimization for both receptor and compounds was performed
via AMBER99 and MMFF99X force field implemented in MOE.

Results:
Nine samples (4 - 11) showed a potent suppressive effect on NO production with IC50 values
ranging between (16.9-20.4 μg/mL), respectively. The samples (1 & 2) exhibited a moderate
level of inhibition with IC50 ranging between 33.2 and 57.4 μg/mL, respectively. Interestingly,
sample 4 consisting of compounds (13-15, 19-26, 28) that mostly belongs to the group fatty acid ester
and phthalic acid ester showed the most potent suppressive effect. Molecular docking results revealed
that the current local SLT constituents presented noticeable potency in different extract samples.

Conclusion:
Variable suppressive effects on NO were detected in the current SLT samples, where
sample 4 was the most potent among all. The extract of the latter exhibited molecular interaction
with the first shell amino acid residues of Inducible nitric oxide synthase (iNOS), which may anchor
the plasticity and selectivity of the compounds present in it. The samples (4 -11) showed a potent
inhibitory effect on the NO, where compound 26 (Phthalic acid ester) is common, and its adequate
concentration may account for augmented biological activity. These results may effectively
highlight their adverse effects on cardiovascular health and etiology and/or progression of cancer
and may help in strengthening the social and governmental efforts in minimizing the use of these
substances.
Synthesis of Antibacterial Oxide of Copper for Potential Application as
Antifouling Agent
Authors: Bhagat Neeru , Pandey Brajesh 
Published: November 2021

Background:
Copper oxide nanoparticles have become very important due to their numerous
applications and ease of synthesis. Out of the two oxides of copper, cuprous oxide exhibits
better antibacterial, antimicrobial, and antifouling properties.

Objective:
The study aimed to find a way of synthesizing stable and eco-friendly oxide of copper and
test it for antibacterial properties.

Methods:
The precipitation method was employed for the synthesis of nanoparticles. NaOH and
Moringa oleifera leaves extract were used as the reducing agents to obtain two different sets of samples.

Results:
Good phases of copper oxides were formed for all the samples (cuprous as well as cupric
oxides). SEM studies showed that the structure of cupric oxide (CuO), formed at higher calcination
temperatures, is well defined when synthesized using a hybrid method.

Conclusion:
Our studies indicate that the hybrid method of synthesis used by us is a more effective
and quicker way of synthesizing cuprous oxide (Cu2O), which exhibits higher antibacterial properties
as compared to cupric oxide (CuO).
Patient, Disease, and Drug-Related Risk Factors Associated with Phenytoin-
Induced Cutaneous Adverse Drug Reactions in South Indian Epileptic
Patients - A Prospective Case-Control Study
Authors: Pattharachayakul Sutthiporn , John Shobana , Canyuk Bhutorn , Anand T.C. Vijay , Sukasem Chonlaphat 
Published: November 2021

Background:
Phenytoin is the most commonly reported aromatic Anti-Epileptic Drug
(AED) to cause Cutaneous Adverse Drug Reactions (CADRs). Cutaneous adverse drug reactions
may be immune or non-immune mediated. It has been observed that predisposition is multifactorial
and that gene mutations alone cannot be the cause.

Objectives:
In this study, we investigated the patient, disease, and drug-related risk factors associated
with phenytoin-induced cutaneous adverse drug reactions in South Indian epileptic patients.

Methods:
This study was conducted as a single-center prospective case-control study over a period
of 13 months. The Fisher’s exact test and multivariate binary logistic regression analysis were used
to test the association of single and multiple variables, respectively.

Results:
This study comprised 26 patients with phenytoin-induced cutaneous adverse drug reactions
(PHT-CARDs) and 32 phenytoin-tolerant controls with a mean age of 40.60±18.15 and
36.21±14.71 years, respectively. Among 26 phenytoin-induced cutaneous adverse drug reactions,
76.92% cases were mild-moderate reactions and 23.07% were severe. The onset latency period of
these reactions ranged from 7-42 days. The multivariate analysis showed that multiple AEDs (OR
=18.62, 95% CI 4.28-80.87, p=< .001) and comorbidities (OR= 5.98, 95% CI 1.33-26.78, p=.01)
are risk factors for PHT-CADRs. PHT-SCARs were shown to be associated with previous allergy
history (OR= 31, % CI 2.40-398.8, p=.008).

Conclusion:
The risk factors found to be associated with CARDs in South Indian Epileptic patients
are multiple AEDs, comorbidities, and past allergic history. Therefore, physicians and other
associated health care professionals should closely monitor the patients when phenytoin is employed.
Finite Element Simulation and Deformation Control of High-Speed
Milling of Al7050-T7451 Thin-Walled Parts
Authors: Yang Song , Yang Jun-X. , Wang Fei-Y. 
Published: November 2021

Background:
To reduce environmental pollution and improve resource utilization,
lightweight equipment has become an important development trend of manufacturing. Therefore,
thin-walled parts are being widely used in automobiles, aerospace, etc. due to their lightweight and
high specific strength. However, they usually deform during machining due to poor stiffness.

Objective:
To reduce the machining deformation, the finite element method has been used to analyze
the deformation law of thin-walled parts.

Method:
A 3D milling model of Al7050-T7451 thin-walled parts was established. Then, the influence
of hole structure, rib, and auxiliary support on the deformation was investigated under the
condition of optimized parameters. Moreover, some related patents on the research of machining
deformation of thin-walled parts were also consulted.

Results:
The results showed that the established 3D model could accurately predict the machining
deformation of thin-walled parts. The machining deformation on the edges is more severe due to
holes that weaken the stiffness of thin-walled parts. Besides, ribbed slab and auxiliary support can
shorten machining deformation by 71.9% and 65.2%, respectively.
Hubungan Antara Kontrol Diri dengan Perilaku Konsumtif Melalui Online Shop pada Mahasiswi
Authors: Sudarisman Hergita Syi Vadila 
Published: November 2021

Kemudahan dalam melakukan belanja secara online memberikan cara baru pada konsumen dalam membelibarang, sehingga hal ini dapat lebih mempermudah konsumen dalam melakukan transaksi dan cenderung berperilaku konsumtif. Sementara itu, kontrol diri merupakan hal penting untuk mengendalikan perilaku konsumtif. Penelitian ini bertujuan untuk mengetahui hubungan antara kontrol diri dengan perilaku konsumtif melalui online shop pada mahasiswi. Penelitian ini menggunakan pendekatan kuantitatif. Subjek dalam penelitian ini adalah mahasiswi Universitas Negeri Yogyakarta angkatan 2016 sebanyak 130 mahasiswi. Metode pengambilan sampel yang digunakan adalah simple random sampling. Instrumen penelitian ini menggunakan dua skala yaitu skala perilaku konsumtif melalui online shop yang terdiri dari 26 item dengan reliabilitas sebesar 0,966 serta skala kontrol diri yang terdiri dari 15 item dengan reliabilitas sebesar 0,920. Hasil analisis data menggunakan Pearson Product Moment menunjukkan bahwa terdapat hubungan antara kontrol diri dengan perilaku konsumtif melalui online shop pada mahasiswi Universitas Negeri Yogyakarta angkatan 2016, dengan nilai korelasi sebesar -0,861 dan signifikansi p < 0.05 yang artinya semakin rendah kontrol diri maka semakin tinggi perilaku konsumtif melalui online shop, begitu pula sebaliknya..
Pengaruh Kontrol Diri Terhadap Intensitas Penggunaan Smartphone Pada Remaja
Authors: Nurningtyas Fernita , Ayriza Yulia 
Published: November 2021

Penelitian ini bertujuan untuk mengetahui pengaruh kontrol diri terhadap intensitas penggunaan smartphone pada remaja. Adapun pendekatan yang digunakan ialah pendekatan kuantitatif dengan jenis penelitian ex post facto. Penelitian ini dilakukan di Kota Yogyakarta dengan subjek penelitian remaja berusia 15-18 tahun dan sampel berjumlah 384 remaja yang diambil dengan menggunakan teknik incidental sampling. Pengumpulan data dilakukan dengan menggunakan metode kuisioner. Instrumen data yang digunakan adalah skala kontrol diri dan skala intensitas penggunaan smartphone. Validitas instrumen dilakukan dengan menilai validitas isi melalui expert judgment. Pengujian reliabilitas instrument dilakukan menggunakan alpha Cronbach dan menunjukkan nilai koefisien 0,908 pada skala kontrol diri. Teknik analisis data pada penelitian ini menggunakan regresi linear sederhana. Hasil penelitian menunjukkan bahwa terdapat pengaruh kontrol diri secara negatif dan signifikan terhadap intensitas penggunaan smartphone pada remaja usia 15-18 tahun di Kota Yogyakarta (β = -0,102, p0,01) yang artinya kontrol diri mampu menjadi prediktor terhadap intensitas penggunaan smartphone.
Impact analysis of expanding narrow-spectrum antibiotic use for children with ear, sinus and throat infections
Authors: Barbosa Carolina , Breck Andrew , King Grant , Bass Sarah , Kook Yoojin , Honeycutt Amanda , Esposito Dominick 
Published: November 2021

Aim:Estimate the impacts treating acute respiratory tract infections (ARTIs) in children aged 6 months through 12 years with narrow-spectrum antibiotics.Materials & methods:Decision-tree model to estimate children’s health, healthcare utilization and costs, and caregiver’s time and costs for using narrow-spectrum antibiotics in eligible children with an ARTI, compared with current use of narrow- and broad-spectrum antibiotics.Results:Reduced adverse drug reactions by 35,750 (14%) cases) and 4750 (12%) fewer emergency department visits, 300 (12%) fewer hospitalizations, and 50,500 (10%) avoided outpatient visits. Annual healthcare costs fell by US$120 million (22%). Total societal costs declined by US$131 million (20%).Conclusion:National implementation of narrow-spectrum antibiotics to treat ARTIs in children improves patient outcomes and reduces caregiver burden and annual healthcare costs.
Impact of a Novel Diabetes Support System on a Cohort of Individuals With Type 1 Diabetes Treated With Multiple Daily Injections: A Multicenter Randomized Study
Authors: Bisio Alessandro , Anderson Stacey , Norlander Lisa , O’Malley Grenye , Robic Jessica , Ogyaadu Selassie , Hsu Liana , Levister Camilla , Ekhlaspour Laya , Lam David W. , Levy Carol , Buckingham Bruce , Breton Marc D. 
Published: November 2021

OBJECTIVE
Achieving optimal glycemic control for many individuals with type 1 diabetes (T1D) remains challenging, even with the advent of newer management tools, including continuous glucose monitoring (CGM). Modern management of T1D generates a wealth of data; however, use of these data to optimize glycemic control remains limited. We evaluated the impact of a CGM-based decision support system (DSS) in patients with T1D using multiple daily injections (MDI).

RESEARCH DESIGN AND METHODS
The studied DSS included real-time dosing advice and retrospective therapy optimization. Adults and adolescents (age &gt;15 years) with T1D using MDI were enrolled at three sites in a 14-week randomized controlled trial of MDI + CGM + DSS versus MDI + CGM. All participants (N = 80) used degludec basal insulin and Dexcom G5 CGM. CGM-based and patient-reported outcomes were analyzed. Within the DSS group, ad hoc analysis further contrasted active versus nonactive DSS users.

RESULTS
No significant differences were detected between experimental and control groups (e.g., time in range [TIR] +3.3% with CGM vs. +4.4% with DSS). Participants in both groups reported lower HbA1c (−0.3%; P = 0.001) with respect to baseline. While TIR may have improved in both groups, it was statistically significant only for DSS; the same was apparent for time spent &lt;60 mg/dL. Active versus nonactive DSS users showed lower risk of and exposure to hypoglycemia with system use.

CONCLUSIONS
Our DSS seems to be a feasible option for individuals using MDI, although the glycemic benefits associated with use need to be further investigated. System design, therapy requirements, and target population should be further refined prior to use in clinical care.
Monitoring Perubahan Penggunaan Lahan Menggunakan Citra SPOT 6 dan SPOT 7 di Kota Semarang
Authors: Dalilah Anisa , Malinda Alviana Ratna , Oktapiyansyah Recky , Monicha Windha , Purnama Fajar 
Published: November 2021

Perubahan penggunaan lahan terjadi di beberapa kota besar salah satunya adalah kota Semarang. Perubahan penggunaan lahan yang terjadi tentunya dapat memberikan perubahan nilai ekonomis lahan, namun apabila tidak dilakukan pengelolaan dengan baik, pada waktu yang akan datang dapat mengakibatkan degradasi nilai ekonomis lahan. Penelitian ini bertujuan untuk mengetahui perubahan penggunaan lahan di kota Semarang serta untuk mengetahui faktor-faktor yang mempengaruhi perubahan penggunaan lahan. Metode yang digunakan yaitu analisis citra multitemporal, menggunakan citra Spot 6 dan Spot 7 Pada citra 2013 dan citra 2019 untuk mengetahui perubahan penggunaan lahan. Hasil yang diproleh yaitu Peta perubahan penggunaan lahan yang telah diuji akurasi dengan cara Ground chek ke lapangan, akurasi data yang didapatkan kira kira 50% dari hasil survey ke lapangan sebagian besar yang telah dilakukan terdapat perubahan penggunaan lahan di titik sampel yang telah ditentukan seperti hutan berubah menjadi lahan terbuka hijau dan lahan terbangun sedangkan area tambak berubah menjadi area persawahan.
Tradisi Meurup-Urup dan Nilai-Nilai Karakter Masyarakat Banjar Munti Gunung Desa Tianyar Barat Kabupaten Karangasem
Authors: Suastika I Nengah 
Published: November 2021

Penelitian ini bertujuan untuk menganalisis dan memformulasi nilai-nilai karakter yang ada pada masyarakat Desa Munti Gunung yang dapat dijadikan modal sosial untuk membangun kemandirian masyarakat, memformulasi proses internalisasi sikap hormat dan bertangungjawab pada masyarakat Desa Munti Gunung, dan menganalisis implementasi sikap hormat dan bertangungjawab pada kehidupan masyarakat Desa Munti Gunung. Penelitian ini secara metodologis menggunakan pendekatan kualitatif. Subjek penelitian ini adalah tokoh masyarakat, anggota karang taruna, dan masyarakat. Objek penelitiannya adalah nilai-nila karakter dan kegiatan meurup-urup. Instrumen penelitian dalam penelitian ini, menggunakan prinsip bahwa peneliti adalah instrumen utama penelitian (human instrumen). Teknik analisis data dalam penelitian ini akan dilakukan secara kualitatif. Hasil penelitian menunjukkan pengembangan karakter masyarakat Banjar Munti Gunung dibangun dari landasan filosofis tri hita karana, sehingga membangun sikap jujur, bertangungjab, toleran, empati, kreatif, dan kebersamaan. Sedangkan proses internalisasi nilai-nilai karakter pada masyarakat Banjar Munti Gunung dibangun dari proses-proses kehidupan keluarga, organisasi sosial (sekeha), sekolah dan masyarakat. Penerapan nilai-nilai karakter, khsususnya sikap hormat dan tangungjawab terimplementasi pada semua aspek kehidupan masyarakat.
PENGUKURAN TINGKAT KESIAPAN IMPLEMENTASI E-LEARNING (E-LEARNING READINESS) MENGGUNAKAN MODEL CHAPNICK STUDI KASUS : SMKN 1 GEROKGAK
Authors: Budiarta I Kadek Edi , Pradnyana I Made Ardwi , Divayana Dewa Gede Hendra 
Published: November 2021

Perkembangan era globalisasi ini tidak terlepas dari salah satu bidang yaitu Teknologi Informasi dan Komunikasi (TIK). Penerapan internet di bidang pendidikan yang paling jelas implementasinya dan sedang menjadi trend sekarang adalah penggunaan e-learning. (Chapnick, 2000) memperingatkan bahwa harus berhati-hati dalam proses adopsi e-learning untuk suatu organisasi. Mereka menegaskan bahwa adopsi e-learning tanpa perencanaan yang cermat kemungkinan besar akan berakhir dengan cost overruns, produk pembelajaran yang tidak menarik, dan kegagalan. Maka dari itu peneliti melakukan penelitian tentang tingkat kesiapan suatu organisasi dalam penggunaan elearning (elearning readiness) , elearning readiness merupakan kesiapan mental atau fisik suatu organisasi untuk suatu pengalaman pembelajaran. Dalam penelitian ini peneliti mengambil studi kasus di SMKN 1 Gerokgak , menggunakan metode penelitian survey model Chapnick dengan 8 kategori yaitu Psycological, Sociological, Enviromental, Human Resources, Financial, Technological skill, Equipment ,dan Content. Setelah semua data terkumpul maka selanjutnya peneliti melakukan pengukuran dengan skala pengukuran Aydin & Tasci untuk menentukan hasil akhir.Hasil penelitian menunjukkan bahwa SMKN 1 Gerokgak mendapatkan skor e-learning readiness sebesar 3,98. Yang berarti SMKN 1 Gerokgak telah siap, tetapi membutuhkan sedikit perbaikan dalam faktor psycological readiness, environmental readiness, human resource readiness, financial readiness, technological skill readiness, dan equipment radiness. Sedangkan faktor yang telah siap yaitu sociological readiness dan content readiness.Kata kunci : Globalisasi, trend , e-learning, Chapnick, e-learning readiness
Analisis Retorika Gibran Rakabuming Pada Panggung Debat Pilwalkot Solo 2020
Authors: Hidayat Syamsul 
Published: November 2021

Dalam kajian ilmu pengetahuan seni berbicara atau sering disebut dengan retorika seseorang akan lebih mudah menyampaikan maksud dan tujuan dari apa yang dibicarakannya serta terasa enak didengarkannya dan tidak membuat bosan pendengarnya. Retorika merupakan salah satu kunci sukses didalam suatu kampanye atau debat politik karena menggunakan kata-kata yang menarik simpati masyarakat dalam mengkomunikasikan ideologi ataupun program kerja yang mereka tawarkan sehingga nantinya mendapatkan dukungan pada saat pemilihan umum (pemilu). Gibran Rakabuming yang kita ketahui adalah seorang pengusaha muda sukses yang kini melebarkan sayapnya untuk terjun dalam dunia politik yaitu menjadi walikota Surakarta. Dengan berlatar belakang pengusaha yang memiliki kemampuan beretorika yang baik, dapat digunakan untuk mengambil simpatik masyarakat dalam proses pemilihan pilwalkot Surakarta. Penelitian ini berjudul Analisis Retorika Gibran Rakabuming Pada Panggung Debat Pilwalkot Solo 2020. Tujuan dari penelitian ini adalah untuk melihat bagaimana Analisis Retorika Gibran Rakabuming yang digunakan Pada Panggung Deba Pilwalkot Solo 2020 yang ditayangkan langsung oleh metrotv pada 6 November 2020. Berkaitan dengan hal tersebut hasil penelitian menggunakan teori Retorika menurut Aristoteles yaitu ethos, pathos, logos. a)Ethos Gibran Rakabuming mampu menghubungkan kalimat yang terstruktur dan menata ide dalam makna setiap kalimatnya dalam menyampaikan visi misinya, b)Pathos (bukti emosional) dalam penyampaian visi, Gibran Rakabuming mampu membangkitkan rasa emosi, simpatik, dan bangga, olah vokal yang ditunjukkan Gibran sangat lugas dan tegas lantang terdengar jelas, tidak terlalu cepat, dan penggunaan jedanya juga tepat, sehingga sangat meyakinkan untuk mempersuasi masyarakat, c)Logos (bukti logis) Gibran Rakabuming mampu menghubungkan kalimat yang terstruktur dan menata ide dalam makna setiap kalimatnya dalam menyampaikan visi misinya. Walaupun kalimat yang digunakan Gibran Rakabuming cenderung konotatif tetapi struktur kalimat tetap mengandung penalaran yang logis. Metode yang digunakan dalam penelitian ini adalah penelitian kualitatif deskriptif. Objek penelitian ini berfokus dari tayangan yang diselenggarakan metrotv dan diupload chanel Youtube metrotv yang berjudul “Debat Publik Antar Paslon Pilwalkot Surakarta 2020”. Dari penelitian yang dilakukan oleh peneliti, peneliti menyimpulkan bahwa Gibran Rakabuming dalam melakukan debat pilwalkot Solo memahami dan menerapkan elemen-elemen retorika (ethos, pathos dan logos). Berdasarkan elemen-elemen retorika tersebut pidato yang dikemukakan oleh Gibran Rakabuming mampu memberi dampak signifikan terhadap kesuksesannya dalam memperoleh kepercayaan publik dan juga meningkatkan presentase kemenangan dalam Pemilihan Wali Kota Surakarta.