bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efektifitas Komunikasi Interpersonal Siswa Melalui Metode Diskusi Buzz Group dalam Pembelajaran PAI Kelas VI SDN Bandar Kidul 1 Kediri
Authors: Umam Moh. Latiful 
Published: July 2021

Penelitian ini dibingkai dalam topik besar Metode Pembelajaran yang secara khusus melihat praktek pembelajaran di SDN Bandar Kidul 1 Kediri dari komunikasi interpersonal siswa dalam kelas dengan menggunakan metode buzz group. Penelitian ini diharapkan memiliki nilai praktis terhadap pembelajaran PAI.
Permasalahan yang diajukan dalam penelitian ini meliputi: 1). Bagaimana pelaksanaan metode Diskusi Buzz Group pada Mata Pelajaran PAI di kelas VI SDN Bandar Kidul 1 Kediri, dan 2). Bagaimana efektifitas Komunikasi Interpersonal siswa pada Mata Pelajaran PAI dalam metode Diskusi Buzz Group di kelas VI SDN Bandar Kidul 1 Kediri.
Lokasi penelitian ini SD Negeri Bandar Kidul 1 Kediri. Sampel yang digunakan dalam penelitian ini adalah siswa-siswi kelas VI SD Negeri Bandar Kidul 1 Kediri.
Jenis pendekatan penelitian ini adalah penelitian kualitatif. Teknik pengumpulan data yang digunakan (1). Observasi, (2). Wawancara, (3). Tes, (4). Dokumentasi. Dan teknik analisa data yang digunakan adalah reduksi data, paparan data dan penyimpulan. Maka data terkumpul dianalisis dengan bekal senjata intelektual berupa teori sebagaimana ditampilkan dalam Bab II untuk mendapatkan berbagai uraian interperaktif sesuai kaidah penelitian ilmiah yang logis dan rasional atas data yang dikumpulkan.
Akhirnya, penelitian ini berhasil memperoleh temuan sesuai pertanyaan permasalahan yang pada garis besarnya dapat disimpulkan sebagai berikut. 1)pelaksanaan metode diskusi buzz group berjalan lancar, antusias dari anak-anak sangat baik serta memiliki kemanfaatan yang baik dalam kemajuan pemahaman siswa kelas VI pada materi pendidikan agama islam bab sholat tarawih. 2) efektifitasanya siswa pada materi pendidikan agama Islam ada kemajuan dengan menggunakan metode diskusi buzz group serta memperlancar siswa dalam komunikasi di kelas dan memahami materi pelajaran.
PEMBUATAN NANOPARTIKEL PERAK (NPP) DENGAN BIOREDUKTOR EKSTRAK BUAH Muntingia calabura L UNTUK ANALISIS LOGAM MERKURI
Authors: Sari Purwo Ismaya , Firdaus M. Lutfi , Elvia Rina 
Published: July 2021

The goal of this research was to make silver nanoparticles (NPP) with a cherry fruit extract bioreductor which was used for mercury metal analysis by using a digital image method. The process of making silver nanoparticles had done by a bottom up method involving a reduction reaction. The precursors used were 1 mM AgNO3 solution and as a bioreductor was an antioxidant compound which were in cherry fruit extract. Variation of the volume ratio between cherry fruit extract and 1 mM AgNO3 solution was 1: 3, 1: 4, 1: 5, 1: 6, and 1: 7 and the variation of contact time were 5, 15, 30, 45, 1, 2, 3 hours, and 1, 2, 7 days. The most optimum results of silver nanoparticles were synthesized with 1 : 4 volume ratio and 1 hour contact time. From the results of selectivity test, it was known that silver nanoparticles were made selective toward Hg and Fe metal. The sensitivity test toward Hg metal, it was known that NPP can detect mercury metal with the smallest concentration of 16,7 ppb.
PENERAPAN MODEL PEMBELAJARAN INKUIRI DENGAN MEDIA DART BOARD UNTUK MENINGKATKAN HASIL BELAJAR KIMIA Di KELAS XI IPA 1 SMA NEGERI 9 KOTA BENGKULU TAHUN AJARAN 2016/2017
Authors: Wulandari Defrilina Sri Eka , Bahar Amrul , Elvinawati Elvinawati 
Published: July 2021

[THE APPLICATION OF INQUIRY LEARNING MODEL WITH DART BOARDMEDIA TO IMPROVE THE STUDIED RESULTS OF CHEMISTRY IN CLASS XI IPA 1 SMA NEGERI 9 CITY OF BENGKULU AT 2016/2017 ACADEMIC YEAR] This research aims to improve the learning outcomes and student activity model of learning by implementing a inkuiri dart board with media in class XI IPA 1 SMA Negeri 9 Bengkulu city at 2016/2017. Academic year. This research is a class action research. This research was conducted in three cycles consisting of 4 stages each namely planning, implementation, observation, and reflection. The subject of this research is the whole grade X IPA 1 SMA N 9 Bengkulu city on 2016/2017 academic year. From the results, it can be concluded that the process of learning to apply inquiry learning models by using a Dart Board media proved can improve the activity and outcomes of study chemistry grade XI IPA 1 SMA Negeri 9 Bengkulu city on 2016/2017 academic year. It can be seen from the average value of students in Ist cycle are 61.61, classical absorption 77.02% and learning of classical completeness at 19.35%..In Iind Cycle obtained an average score of students amounted to 71.29; absorption of conventional 79.21% and completeness studied conventional 35.48%. In IIIth cycle received an average rating of students at 84.51; absorption of conventional 84.51% and completeness studied classical 90.32%.. For the entire sequence of an increase in the activity of the students which can be seen from the mean value – 1st cycle averages of 22.5, 2nd cycle at 25; and in 3th cycle at 29.
PERBANDINGAN HASIL DAN MINAT BELAJAR KIMIA SISWA KELAS X IPA MENGGUNAKAN MODEL PEMBELAJARAN KOOPERATIF SNOWBALL THROWING DAN TALKING STICK PADA KURIKULUM-2013 DI SMAN 10 KOTABENGKULU
Authors: Saputri Rika Juwita , Sumpono Sumpono , Elvia Rina 
Published: July 2021

The purpose of this research to determine the difference in learning outcome and interest of students on chemistry learning between class which applied snowball throwing and class which applied talking stick learning model on nomenclatur of chemical compounds material in curriculum-2013 of grade X IPA in SMA Negeri 10 Bengkulu City. Research conducted is a research with the type of quasi experiment. Analysis of the data used are mean values, normality test, homogeneity test, and t-test. Chemistry learning outcome data obtained pretest and posttest value where average improvement value of cognitive learning result for snowball throwing class and talking stick class are 56,970 and 45,606. While the interest of students learning of both experiment classes procure percentage are 81,567% and 75,373%. The result of t test with significant level (? = 0,05), then got value for tcount >ttable is 4,734 > 1,669 for learning result and 3,596 > 1,669 for interest learning. The results showed that there were significant differences in learning outcomes and learning interest between classes that applied snowball throwing learning and classes that applied the talking stick learning model.
KARAKTERISASI NANOPARTIKEL KITOSAN EKSTRAK DAUN UBIJALAR (Ipomoea batatas L.) MENGGUNAKAN METODE GELASI IONIK
Authors: Putri Ade Indriani , Sundaryono Agus , Chandra I Nyoman 
Published: July 2021

The purpose of this study is to determine and measure the results of the characterization of Chitosan nanoparticle synthetized from leaves of sweet potato (Ipomoea batatas l.) extracts . The methods used to make nanoparticles is made with Ionic Gelation method based on electrostatic interaction between the Hydroxyl Amine on Chitosan with cluster of negative charge from the polianion NaTPP with conditioned surfactant Tween 80 used as surfactant. Characterization test of nanoparticle morphology in this study obtained using the Fourier Transformation Infra Red (FTIR), and Particle Size Analyzer (PSA). Results with FTIR characterization test from the obtained Chitosan-white purple sweet potato leaf extract nanoparticles has a cluster of N-H and P = O that show the occurrence of ammonium ion interaction between Chitosan with polianion from NaTPP and sweet potato leaves. The interaction seen from wave number and intensities O-H shifting from pure Chitosan at 3425.56 cm-1 to 3427, 51 cm-1, as well as on pure Chitosan N-H absorption undergoes a shift from 1597, 06 cm-1 to becomes 1629.85-1 cm-1, which shows that there has been a cross connective between ammonium ion on Chitosan and Posphat from NaTPP and white purple sweet potato leaf extract. The results of the analysis from the PSA, is known to the average Nanokitosan particle sizes extracts from white purple sweet potato leaf extracts with the addition of NaTPP i.e. of 302.6 nm and that the aim of the research on Chitosan nanoparticle synthesis has been successfully done.
PERBANDINGAN HASIL BELAJAR KIMIA SISWA MENGGUNAKAN MODEL PEMBELAJARAN WORD SQUARE DAN MODEL PEMBELAJARAN SCRAMBLE DI MAN 2 KOTA BENGKULU
Authors: Shintia Weny , Bahar Amrul , Elvia Rina 
Published: July 2021

This study aimed to compare the chemistry learning outcomes of students with using word square model learning and scramble model learning in grade X MAN 2 Kota Bengkulu on the subject of chemistry compound nomenclature. This was quasy experimental research and held in March to May 2018. Population in this study is the entire class X MIA in MAN 2 Kota Bengkulu 2017/2018 academic year, amounting to 149 students. Sample is class X MIA 1 and class X MIA 3. The sample of the research is class X MIA 1 with 32 students and class X MIA 3 with 33 students. Data analysis used normality test, homogeneity test and hypothesis test (t test). Data analysis was performed using Statistical Package for The Social Science (SPSS) version 16.Improvement student’s learning outcomes in this research was taken from difference assess of pretest and posttest. At experiment class of I average value improvement of student’s learning outcomes was 50.32. while at experiment class of II, average value improvement of student’s learning outcomes was 44.4 . through some statistic test, there was t-test (? = 0.05) which done test the hypothesis to obtained the test result was t value = 2.174 and t tabel = 1.998. The result of data analysis showed that were significant differences in student learning outcomes between the class which implemented word square model learning and the class which implemented scramble model learning. Student learning outcomes that apply the word square model of learning better than student learning outcomes that apply the scramble model of learning.
PERBANDINGAN PEMBELAJARAN KOOPERATIF TIPE STRUCTURED NUMBERED HEADS (SNH) DAN NUMBERED HEAD TOGETHER (NHT) TERHADAP KEMAMPUAN BERPIKIR KREATIF SISWA KELAS X MIPA SMAN 6 KOTA BENGKULU
Authors: Elyani Evi , Sumpono Sumpono , Amir Hermansyah 
Published: July 2021

The purpose of this research is to measuring the comparison of students creative thinking ability between cooperative learning model type Stuctured Numbered Heads (SNH) and Numbered Head Together (NHT) on nomenclatur of chemical compounds material in curriculum 2013 of grade X MIPA SMA Negeri 6 Bengkulu city school year 2017/2018. This research is a quasi-experimental research with total population 118 students and sample 57 students with class X MIPA D as experiment class I that apply cooperative learning model type SNH and class X MIPA B as experiment class II applying cooperative learning model type NHT. Analysis of the data used are mean values, Percentage Indicator, normality test, homogeneity test, and hypothesis test (t test). The students' creative thinking ability in this study is seen from the difference between pretest and posttest. In the experimental class I, the average value of students creative thinking ability was 51,851 while the experimental class II was 46,916. The result of t test (? = 0,05) obtained tcount> ttable is 2,645> 2,0040 indicates the accepted hypothesis means that there is a significant difference between students' creative thinking ability using cooperative learning model type SNH and NHT, where the model of cooperative learning type SNH is more influential on students’ creative thinking ability compared with cooperative learning type model NHT.
ANALISIS KEMAMPUAN PENYELESAIAN SOAL KIMIA LEVEL SIMBOLIK SECARA SISTEMATIS PADA MATERI KELARUTAN DAN HASIL KALI KELARUTAN
Authors: Firdaus Miming , Rohiat Salastri , Amir Hermansyah 
Published: July 2021

Penelitian ini bertujuan untuk mengetahui kemampuan representasi simbolik siswa kelas XI IPA SMA N 01 Padang Jaya pada materi kelarutan dan hasil kali kelarutan. Metode yang digunakan dalam penelitian adalah deskriptif dengan pendekatan kuantitatif. Sampel penelitian berjumlah 52 siswa kelas XI IPA SMA N 01 Padang Jaya. Kemampuan representasi simbolik siswa diukur menggunakan tes tertulis berbentuk esai. Teknik analisis data didasarkan pada data yang telah dikumpulkan dari jawaban tes yang diberikan. Berdasarkan hasil analisis data dapat disimpulkan bahwa kemampuan representasi simbolik siswa kelas XI IPA SMA N 01 Padang Jaya pada materi kelarutan dan hasil kali kelarutan masih rendah. Hal ini ditunjukkan dengan rendahnya persentase rata-rata kemampuan representasi simbolik siswa 40% (kategori kurang).
Multi-Omics Data Integration Analysis of an Immune-Related Gene Signature in LGG Patients With Epilepsy
Authors: Cheng Quan , Duan Weiwei , He Shiqing , Li Chen , Cao Hui , Liu Kun , Ye Weijie , Yuan Bo , Xia Zhiwei 
Published: July 2021

BackgroundThe tumor immune microenvironment significantly affects tumor occurrence, progression, and prognosis, but its impact on the prognosis of low-grade glioma (LGG) patients with epilepsy has not been reported. Hence, the purpose of this study is to explore its effect on LGG patients with epilepsy.MethodsThe data of LGG patients derived from the TCGA database. The level of immune cell infiltration and the proportion of 22 immune cells were evaluated by ESTIMATE and CIBERSORT algorithms, respectively. The Cox and LASSO regression analysis was adopted to determine the DEGs, and further established the clustering and risk score models. The association between genomic alterations and risk score was investigated using CNV and somatic mutation data. GSVA was adopted to identify the immunological pathways, immune infiltration and inflammatory profiles related to the signature genes. The Tumor Immune Dysfunction and Exclusion (TIDE) algorithm and GDSC database were used to predict the patient’s response to immunotherapy and chemotherapy, respectively.ResultsThe prognosis of LGG patients with epilepsy was associated with the immune score. Three prognostic DEGs (ABCC3, PDPN, and INA) were screened out. The expression of signature genes was regulated by DNA methylation. The clustering and risk score models could stratify glioma patients into distinct prognosis groups. The risk score was an independent predictor in prognosis, with a high risk-score indicating a poor prognosis, more malignant clinicopathological and genomic aberration features. The nomogram had the better predictive ability. Patients at high risk had a higher level of macrophage infiltration and increased inflammatory activities associated with T cells and macrophages. While the higher percentage of NK CD56bright cell and more active inflammatory activity associated with B cell were present in the low-risk patients. The signature genes participated in the regulation of immune-related pathways, such as IL6-JAK-STAT3 signaling, IFN-α response, IFN-γ response, and TNFA-signaling-via-NFKB pathways. The high-risk patients were more likely to benefit from anti-PD1 and temozolomide (TMZ) treatment.ConclusionAn immune-related gene signature was established based on ABCC3, PDPN, and INA, which can be used to predict the prognosis, immune infiltration status, immunotherapy and chemotherapy response of LGG patients with epilepsy.
Evaluation of a Prototype of a Novel Galactomannan Sandwich Assay Using the VIDAS® Technology for the Diagnosis of Invasive Aspergillosis
Authors: Gallet Salomé , Garnaud Cécile , Dragonetti Céline , Rivoiron Sophie , Cognet Odile , Guo Yuping , Lesénéchal Mylène , Maubon Danièle , Cornet Muriel 
Published: July 2021

ObjectivesTo evaluate the analytical and clinical performance of a prototype of a VIDAS® Galactomannan (GM) unitary test (bioMérieux, Marcy l’Etoile, France) and compare to that of the Platelia™ Aspergillus Ag assay (Bio-Rad, CA, USA).MethodsRepeatability, reproducibility, and freeze-thaw stability of VIDAS®GM were evaluated. Sera from patients at risk of IA were concurrently tested with both the VIDAS®GM and Platelia™ Aspergillus Ag assays. Correlations between the two assays were assessed by Passing Bablok (PB) regression and performance by ROC analysis.ResultsThe correlations between the VIDAS®GM indexes after one and two cycles of freezing/thawing were r=1.00 and r=0.989, respectively. The coefficients of variation for negative, low-positive, and positive sera were 13%, 6%, and 5% for repeatability and 14.4%, 7.2%, and 5.5% for reproducibility. Overall, 126 sera were tested with both assays (44 fresh and 82 frozen). The correlation between VIDAS®GM and Platelia™ Aspergillus Ag was r=0.798. The areas under the curve of the ROC analyses were 0.892 and 0.894, for VIDAS®GM and Platelia™ Aspergillus Ag, respectively.ConclusionsThis new VIDAS®GM prototype assay showed adequate analytical and clinical performance and a good correlation with that of Platelia™ Aspergillus Ag with 126 sera, although these results need to be confirmed in a larger prospective and multicentric study. As for the other VIDAS® assays, VIDAS®GM is a single-sample automated test using a solid reagent strip and receptacle. It is easy to use and suitable for rapid on-demand test results.
Crosslink: An R Package for Network Visualization of Grouped Nodes
Authors: Liu Di , Bai Zhijie , Liu Bing , Li Zongcheng 
Published: July 2021

The demand for network visualization of relationships between nodes attributed to different categories grows in various biomedical research scenarios, such as gene regulatory networks, drug-target networks, ligand-receptor interactions and association networks of multi-omics elements. Elegantly visualizing the relationships between nodes with complex metadata of nodes and edges appended may inspire new insights. Here, we developed the crosslink R package, tailored for network visualization of grouped nodes, to provide a series of flexible functions for generating network diagrams. We first designed a CrossLink class for storage of metadata about nodes and edges and manipulation of node coordinates. Then affine transformation and function mapping transformation are implemented to perform fundamental node coordinates transformation by groups, based on which various network layouts can be defined easily. For convenience, we predefined several commonly used layouts, including row, column, arc, polygon and hive, which also can be combined in one layout. Finally, we designed a user-friendly wrapper function to draw network connections, aesthetic mappings of metadata and decoration with related annotation graphs in one interface by taking advantage of the powerful ggplot2 system. Overall, the crosslink R package is easy-to-use for achieving complex visualization of a network diagram of grouped nodes surrounded by associated annotation graphs.Availability and ImplementationCosslink is an open-source R package, freely available from github:https://github.com/zzwch/crosslink; A detailed user documentation can be found inhttps://zzwch.github.io/crosslink/.
Subthreshold Micropulse Laser vs. Conventional Laser for Central Serous Chorioretinopathy: A Randomized Controlled Clinical Trial
Authors: Zhou Lijun , Lai Kunbei , Jin Ling , Huang Chuangxin , Xu Fabao , Gong Yajun , Li Longhui , Zhu Zhe , Lu Lin , Jin Chenjin 
Published: July 2021

Purpose: To investigate the effectiveness and safety of 577-nm subthreshold micropulse laser (SML) on acute central serous chorioretinopathy (CSC).Methods: One hundred and ten patients with acute CSC were randomized to receive SML or 577-nm conventional laser (CL) treatment. Optical coherence tomography and best-corrected visual acuity (BCVA) were performed before and after treatment.Results: At 3 months, the complete resolution of subretinal fluid (SRF) in 577-nm SML group (72.7%) was lower than that in CL group (89.1%) (Unadjusted RR, 0.82; P = 0.029), but it was 85.5 vs. 92.7% at 6 months (unadjusted RR, 0.92; P = 0.221). The mean LogMAR BCVA significantly improved, and the mean central foveal thickness (CFT) significantly decreased in the SML group and CL group (all P &lt; 0.001) at 6 months. But there was no statistical difference between the two groups (all P &gt; 0.05). In the SML group, obvious retinal pigment epithelium (RPE) damage was shown only in 3.64% at 1 month but 92.7% in the CL group (P &lt; 0.001).Conclusions: Although 577-nm SML has a lower complete absorption of SRF compared with 577-nm CL for acute CSC at 3 months, it is similarly effective as 577-nm CL on improving retinal anatomy and function at 6 months. Importantly, 577-nm SML causes less damage to the retina.
Management Based on Multimodal Brain Monitoring May Improve Functional Connectivity and Post-operative Neurocognition in Elderly Patients Undergoing Spinal Surgery
Authors: Yang Shuyi , Xiao Wei , Wu Hao , Liu Yang , Feng Shuai , Lu Jie , Wang Tianlong 
Published: July 2021

Perioperative neurocognitive disorder (PND) is a common condition in elderly patients undergoing surgery. Sedation, analgesia, regional cerebral oxygen saturation (rSO2), and body temperature are known to be associated with PND, but few studies have examined the contribution of these factors combined in detail. This prospective, randomized, controlled, double-blinded study investigated whether anesthesia management based on multimodal brain monitoring—an anesthesia management algorithm designed by our group—could improve the post-operative cognitive function and brain functional connectivity (FC) in elderly patients undergoing elective spinal surgery with general anesthesia. The patients (aged ≥65 years) were randomized into two groups [control (Group C), n = 12 and intervention (Group I), n = 14]. Patients in Group I were managed with multimodal brain monitoring (patient state index, spectral edge frequency, analgesia nociception index, rSO2, and temperature), and those in Group C were managed with routine anesthesia management. All patients were pre- and post-operatively evaluated (7 days after surgery) with the Montreal Cognitive Assessment (MoCA). Amplitude of low-frequency fluctuation (ALFF) and FC were analyzed after resting-state functional MRI. Serum C-reactive protein (CRP) and lipopolysaccharide levels were measured, and the correlation between FC and changes in inflammatory marker levels was analyzed. Mean post-operative MoCA score was higher in Group I (24.80 ± 2.09) than in Group C (22.56 ± 2.24) (p = 0.04), with no difference in PND incidence between groups (28.57 vs. 16.67%; p = 0.47). Group I also showed significantly increased ALFF values in several brain regions after surgery (p &lt; 0.05), and FC between the left hippocampus and left orbital inferior frontal gyrus (FG), left middle FG, left superior temporal gyrus, and left precentral gyrus was enhanced (p &lt; 0.05), which was negatively correlated with the change in serum CRP (pre vs. post-intervention) (R = −0.58, p = 0.01). These results suggest that management of elderly patients undergoing surgery by multimodal brain monitoring may improve post-operative neurocognition and FC by reducing systemic inflammation.Clinical Trial Registration:http://www.chictr.org.cn/index.aspx, identifier: ChiCTR1900028024.