bluuebunny/crossref_metadata_2025_split huggingface dataset:
The HSV-1 ICP22 protein selectively impairs histone repositioning upon Pol II transcription downstream of genes
Authors: Djakovic Lara , Hennig Thomas , Reinisch Katharina , Milic Andrea , Whisnant Adam , Wolf Katharina , Weiß Elena , Haas Tobias , Grothey Arnhild , Juerges Christopher , Kluge Michael , Wolf Elmar , Erhard Florian , Friedel Caroline , Dolken Lars 
Published: October 2021

Abstract
Herpes simplex virus 1 (HSV-1) infection and stress responses disrupt transcription termination by RNA Polymerase II (Pol II). In HSV-1 infection but not upon salt or heat stress, this is accompanied by a dramatic increase in chromatin accessibility downstream of genes. Here, we show that the HSV-1 immediate-early protein ICP22 is both necessary and sufficient to induce downstream open chromatin regions (dOCRs) upon disrupted transcription termination. This was matched by a marked ICP22-dependent loss of histones downstream of affected genes consistent with impaired histone repositioning in the wake of Pol II. Efficient knock-down of the ICP22-interacting histone chaperon FACT, though insufficient to induce dOCRs in ΔICP22 infection, increased dOCR induction upon wild-type HSV-1 infection. Interestingly, this was accompanied by a marked increase in chromatin accessibility within gene bodies. We propose a model in which allosteric changes in Pol II composition downstream of genes and ICP22-mediated interference with FACT activity explain the differential impairment of histone re-positioning in the wake of Pol II observed in HSV-1 infection.
The Stem Cell Quiescence and Niche Signaling is Disturbed in the Hair Follicle of the Hairpoor Mouse, an MUHH Model Mouse.
Authors: Choi Keonwoo , Park Sang-Hee , Park Seo-Yeon , Yoon Sungjoo Kim 
Published: October 2021

Abstract
Background

Hair follicle stem cells (HFSC) play an essential role in the maintenance of hair homeostasis during the hair cycle in which HFSC remain quiescent most of its duration. The hairpoor mouse (+/HrHp), an animal model of Marie-Unna Hypotrichosis (MUHH), exhibits over-expression of Hairless in the bulge, inner root sheath and outer root sheath of HF and exhibits the same phenotype as in MUHH patients manifesting sparse hair with progression to alopecia with age. In this study, we aimed to understand the hair cycle and the status of HFSC during the hair cycle of the hairpoor mouse to delineate the pathogenesis of MUHH.
Methods

To define the state of the hair follicle, H&E staining was performed. FACS analysis and immunostaining was utilized at the 1st and 2nd telogen stages to observe the HFSCs. Label retaining assay was carried out to determine the quiescent state of hair follicle. Expression of factors in involved in the niche signaling and the Wnt signaling was determined using qRT-PCR.
Results

We found that the number of hair follicle was drastically decreased after 1st telogen, then followed by the intensified disturbance in the hair cycle with shorter anagen as well as 2nd telogen in the hairpoor mouse. The number of CD34 expressing bulges as well as cells were dramatically reduced at the telogen of the HFs and the high proliferation of bulge cells was prominent, suggesting the loss of HFSC quiescence in the hairpoor mouse. The increased cell proliferation in HF was reiterated following the synchronization of hair cycle, leading to accelerating HF cycling. The expression of Fgf18 and Bmp6, the factors involved in the HFSC quiescence, was reduced in the HFSC niche of the hairpoor mouse. Furthermore, expression of Wnt signaling molecules including Wnt7b, Wnt10b and Sfrp1 were disturbed inducing the telogen to anagen transition of HFs in the hairpoor mouse.
Conclusions

These results indicate that the quiescent state of HFSC is not properly maintained in the hairpoor mouse and consequently leading HFs to the completely disarrayed hair cycle. These findings may provide an understanding of an underlying mechanism by which alopecia develops with age in MUHH patients.
An Unformed Chip Thickness Approach to Study the Influence of Process Vibration on Machining Performance in Milling
Authors: Guo Miaoxian , Wang Jianming , Guo Weicheng , Liu Jin , Jiang Xiaohui 
Published: October 2021

Abstract
The vibration in milling process plays a key role in machining, which will significantly affect the machining quality of workpiece. Some vibrations have negative influences on the workpiece surface, while particular vibrations are able to improve machining stability. Therefore, it is critical to distinguish the influence of different types of vibration on the machining quality. A simulation method of undeformed chip thickness considering process vibration is presented in this article, in which a finite element model is established to analyze the dynamic milling process of 7075-T651 aluminum alloy from the aspects of cutting force and temperature. A series of experiments are carried out to verify the effectiveness of the simulation model, and the results show that the proposed model is accurate in predicting milling force and temperature. Furthermore, the effect of milling vibration on machining performance is studied with the proposed method, in which the relationship between amplitude-frequency characteristics of vibration and milling force-temperature fluctuation is revealed. The results show that the proposed method can define the influence of milling vibration and provide a basis for distinguishing favorable and unfavorable vibration parameters of machining quality in milling.
3 Boyutlu Yazıcı ile Farklı Yazdırma Parametreleri Kullanılarak Üretilen Eğme Test Numunelerinin Mekanik Özelliklerinin İncelenmesi
Authors: KAMER Muhammed Safa , DOĞAN Oğuz , TEMİZ Şemsettin , YAYKAŞLI Hakan 
Published: October 2021

Eklemeli imalat yöntemi ile üretilen parçaların mekanik özelliklerinin bilinmesi tasarımcılar ve kullanıcılar için büyük önem teşkil etmektedir. Bu çalışmada, eklemeli imalat yöntemine ait, üretim parametrelerinden nozul sıcaklığı, tabla sıcaklığı ve dolgu deseni değişiminin, eğilmeye karşı olan etkisi deneysel olarak araştırılmıştır. ABS ve PLA malzemeler kullanılarak farklı üretim parametrelerine sahip deney numuneleri üç boyutlu yazıcılar ile üretilmiştir. Üretilen numuneler üç noktalı eğme testine tabi tutulmuştur. Deneyler sonucunda her bir parametrenin etkisinin gözlemlenmesi için kuvvet-sehim eğrileri oluşturulmuş ve sonuçlar değerlendirilmiştir. Sonuç olarak PLA malzemesinin eğilme dayanımının ABS malzemeye göre daha yüksek oldu tespit edilmiştir. Ayrıca PLA malzemesi için nozul sıcaklığının düşmesi ile eğilme dayanımının da büyük oranda düştüğü tespit edilmiştir. Dolgu deseni değişiminin,
hem ABS hem de PLA malzemesi için eğilme dayanımını kayda değer oranda değiştirdiği gözlemlenmiştir.
Design of Experiments Application for Machining Process Analyse
Authors: Javorek Lubomir , Vargovská Maria 
Published: October 2021

In this contribution are results from machining of the aluminium alloy by spiral router. The experiment was designed as full 3 - factors and 2-levels process and for evaluation of input factors to output parameters – Fx and Fy components were used Paret´s diagram and Lorentz´s line. The input parameters were: revolution speed (4000/min. and 6000/min.), working engagement of a cutting edge (depth of cut) ae (1 mm and 3 mm), back engagement of a cutting edge (with of cut) ap (5 mm and 15 mm) and down (climb) milling.
Políticas públicas e mobilidade social
Authors: Polli Gislei Mocelin , Martinelli Jamille , Zugman Ari , Oliveira Fabio , Doi Francislaine Wiczneski , Dias Maria Sara de Lima , Tavares Juliana 
Published: October 2021

A educação tem se mostrado uma importante ferramenta de transformação social. A partir dessa compreensão, políticas públicas para acesso ao ensino superior têm sido desenvolvidas no Brasil com o objetivo de promover igualdade social. O Programa Universidade para Todos (PROUNI) é direcionado a estudantes com renda familiar de até três salários mínimos e atinge um número crescente de estudantes. Este estudo objetivou averiguar a ascensão desses estudantes beneficiados pelo PROUNI, envolvendo três dimensões: satisfação profissional, econômica e pessoal. Para tanto, foram contatados 1200 alunos egressos de uma Universidade privada que foram beneficiados pelo PROUNI. Os questionários foram enviados por e-mail e foram obtidas 212 respostas. A análise foi realizada por meio de estatística descritiva e relacional. Os resultados indicam que a graduação universitária através do PROUNI propiciou mobilidade social ascendente. A maioria dos entrevistados declarou que obteve melhorias em sua vida, tanto nos aspectos pessoais, profissionais e econômicos, o que ressalta a importância da existência de políticas públicas voltadas ao acesso à educação.
Des expressions et des sentiments sur des pavements dionysiaques de l’Algérie romaine
Authors: SERRADJ-REMİLİ Nedjma 
Published: October 2021

The figurative ancient mosaics often represent “living” paintings which depict mythological, historical or real personages who manage to express various feelings thanks to the ingenuity of the mosaic craftsmen.
Indeed, the art of ancient mosaic has not ceased to evolve since the Hellenistic period in the direction of the translation of the emotions and feelings that give life to the myths and legends represented.
The mosaics which decorated the ceremonial and reception rooms in luxurious domus did not only play an ornamental role, they entertained the guests, stimulated all their senses and provoked the exchange of conversations around the table. The Dionysian mosaics were particularly intended for this function because Dionysus is the god of the banquet!
By admiring some of the many pavements of the Dionysian legend of Roman Algeria, one can detect the rendering of emotions and soak up an unreal and almost real atmosphere at the same time! ...
This article is an invitation to discover a whole range of sometimes contradictory feelings that appear on mosaics; we will thus be able to see how the African mosaicists from the end of the 2nd to the 5th century A.D. used various methods to make their personages more expressive and alive.
Reburial of Mosaics: Field Experiment Comparing Six Different Systems Based on The Results of Monitoring Station in Perge
Authors: YEŞİL Şehrigül 
Published: October 2021

The effectiveness of six different reburial systems was investigated by means of a monitoring station installed on a part of approximately 110 square meters of mosaic, defined as basilica thermarum in the Southern Baths of the ancient city of Perge. The scope of the study covers the monitoring of six different reburial systems consisting of only soil filling on the tessellatum layer; only sand filling on the tessellatum layer; sand filling on geotextile laid on the tessellatum surface; sand and gravel, respectively on geotextile laid on the tessellatum surface; geotextile and pozzolana on the tessellatum surface, and finally, approximately 5 cm sand, geotextile, and 15 cm sand on the tessellatum surface. Key parameters, which lead to deterioration such as moisture content in these systems, system response to the precipitation, temperature change, acidity, salt content, and plant formation were evaluated comparatively.
In these systems, Decagon 10HS soil moisture sensor for moisture measurements and Apogee ST100 soil temperature sensor for temperature measurements were employed. Atmospheric humidity, atmospheric temperature and precipitation data were collected with a Davis® Vantage Vue™ Wireless Weather Station set. Data of salt content, acidity and elemental composition were obtained through conductivity analysis, pH tests, X-ray fluorescence (PED-XRF) analysis. Having reached under the reburial system, species analysis of plants that cause mosaic deterioration was realized, and the coverage degree of those plants was determined according to the Braun-Blanquet cover-abundance scale. This research, in which data for the years 2017-2018 were evaluated, showed that each monitored reburial system had certain advantages and disadvantages according to the above-mentioned parameters.
Sentiment Classification for Film Reviews by Reducing Additional Introduced Sentiment Bias
Authors: Effendi Fery Ardiansyah , Yuliant Sibaroni  
Published: October 2021

Film business and its individual reviews cannot be separated and film review sites such as IMDb is a credible source of reviews posted in public forums. With IMDb site reviews being unstructured and bias-heavy, classification methods by reducing additional sentiment bias is needed to create a balanced classification with lower polarity bias. Elimination of additional sentiment bias will improve the model as polarity is defined by non-bias method, resulting in models correctly defined which sequences of words is either positive or negative. This research limits the dataset by 50.000 rows of randomly extracted reviews from the IMDb website using dataset preparation methods such as Preprocessing, POS-Tagging, and Word Embeddings. Then preprocessed data is used in classification methods such as ANN, SWN, and SO-Cal. This paper also used bias processing methods such as Hyperparameter Tuning and BPM, with outputs evaluated using Accuracy and PBR metrics. This research yields 77.39 % for ANN, 66.32% for BPM, 75.6% for SO-Cal, and 76.26% for Hybrid classification. Best PBR resulted in two lexicon-based methods on 0.0009 for BPM, and 0.00006 for SO-Cal. More advanced model configuration in ANN can improve the model, and much complex lexicon models will be a future in the research topic.
New Games via soft-I-Semi-g-Separation axioms
Authors: Mohammad R.J. , Esmaeel R.B. 
Published: October 2021

In this article, the notions are introduced by using soft ideal and soft semi-open sets, which are - - - -closed sets " -closed" where many of the properties of these sets are clarified. Some games by using soft- -semi, soft separation axioms: like ( 0 ( 0 Using many figures and proposition to study the relationships among these kinds of games with some examples are explained.
Predictors of Health-Related Quality of Life among Thai People with Coronary Heart Disease: A Preliminary Study
Authors: Meesoonthorn Kanthima , Nilmanat Kittikorn , Boonyasopun Umaporn , Campbell Cathy , Logan Jeongok 
Published: October 2021

Objective: To examine the prediction of severity of illness, health promoting behaviors, cardiac self-efficacy, and acceptance of illness on health-related quality of life (HRQOL) among Thai people with coronary heart disease (CHD) in Thailand.Material and Methods: A cross-sectional design was used. A quota sampling was used to recruit 110 people with CHD, who met the inclusion criteria, from 20 selected hospitals across Thailand. Five self-reporting questionnaires were used: a demographic data questionnaire, Thai version of MacNew HRQOL, Thai version of Health-Promoting Lifestyle Profile-II, Thai version of Cardiac Self-Efficacy Scale Questionnaire, and the Thai version of Acceptance of Illness Scale. Data were analyzed using descriptive statistics, a point-biserial correlation or a bivariate Pearson’s correlation and multiple stepwise regression analyses. Results: One hundred and ten people were included. Most of the participants were men (64.5%) with an average age of 62.07±9.98 years. Most of them (76.4%) were best categorized as class I under the Canadian Cardiovascular Society (CCS) classification system. The findings showed that 46 percent of the variance (adjusted R2 =0.46) for HRQOL was explained by being CCS class I (β=0.22, p-value<0.010), cardiac self-efficacy (β=0.41, p-value<0.010) and acceptance of illness (β=0.35, p-value<0.010). Health promoting behavior was a non-significant predictor of HRQOL (β=0.10, p-value=0.260).Conclusion: The results support the severity of illness, cardiac self-efficacy, and acceptance of illness in explaining HRQOL among people with CHD. Therefore, nursing interventions that are suitable for the severity of the disease, and aimed at boosting cardiac self-efficacy and acceptance of illness should be considered to enhance HRQOL.
ANALISIS KEMAMPUAN LITERASI SAINS DAN KETERAMPILAN BERPIKIR KRITIS SISWA TERHADAP COVID-19 BERDASARKAN MATERI YANG RELEVAN DALAM PEMBELAJARAN BIOLOGI
Authors: Ferdyan Rhavy , Arsih Fitri 
Published: October 2021

Pendidikan sangat berperan penting dalam memfasilitasi siswa dalam memahami konsep dari peristiwa yang belakangan muncul seperti pandemi COVID-19. Peran pendidikan secara penuh adalah dalam menuntun siswa untuk mendapatkan informasi mengenai COVID-19 salah satunya melalui pembelajaran biologi yang memiliki materi relevan dengan COVID-19. Ketersediaan informasi mengenai COVID-19 dan cara menyikapinya ditentukan oleh kemampuan literasi sains dan keterampilan berpikir kritis siswa. Tujuan penelitian ini adalah untuk melihat tingkat kemampuan literasi sains dan keterampilan berpikir kritis siwa mengenai COVID-19. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kualitatif yang dilakukan di SMAN 16 Padang. Hasil peneltian menunjukkan kemampuan literasi sains siswa terhadap COVID-19 berdasarkan materi biologi yang relevan adalah 57,4 dengan kriteria sedang. Sedangkan tingkat keterampilan berpikir kritis siswa terhadap COVID-19 adalah 60.8% dengan kriteria rendah. Hal ini disebabkan oleh kurangnya materi pembelajaran yang mengarahkan dan melatih siswa untuk meningkatkan kemampuan literasi sains dan keterampilan berpikir kritis, karena kedua kemampuan tersebut sangat dibutuhkan dalam menjaga keselamatan diri menghadapi pandemi. Sangat diperlukan sebuah rancangan untuk mengembangkan materi pembelajaran biologi untuk meningkatkan kedua kemampuan tersebut.
KEMANDIRIAN DAN MOTIVASI BELAJAR BIOLOGI SISWA MENGGUNAKAN GOOGLE CLASSROOM PADA MASA PANDEMI COVID-19
Authors: Rikizaputra Rikizaputra , Sembiring Al Khudri , Dinata Marta , Azhar Minda , Yohandri Yohandri 
Published: October 2021

Kemandirian dan motivasi belajar siswa melalui google classroom menjadi penting dalam situasi pandemi Covid-19. Tujuan penelitian ini adalah untuk menganalisis dampak google classroom terhadap kemandirian dan motivasi belajar siswa pada masa pandemi covid-19. Penelitian ini merupakan penelitian kuantitatif dengan metode survey. Populasi dalam penelitian ini berjumlah 52 siswa dengan sampel penelitian 52 siswa yang diambil dengan menggunakan teknik total sempling. Teknik pengumpulan data menggunakan kuesioner yang terdiri dari 30 pernyataan dengan skala likert dan wawancara terhadap siswa. Berdasarkan analisis data yang dilakukan dengan deskriptif perentase yang mengacu pada skala likert 1-4 maka diperoleh rata-rata kemandirian belajar 2,19 dan rerata motivasi belajar siswa diperoleh 2,46. Dengan demikian dapat disimpulkan bahwa pengunaan google classroom dalam pembelajaran pada masa pendemi covid 19 memberikan dampak yang sedang terhadap kemandirian dan berdampak kuat terhadap motivasi. Penggunaan google classroom pada masa pandemi covid-19 perlu ditingkatkan kualitas penggunannya dalam pembelajaran.
Pendidikan Literasi Keuangan Pada Anak Yang Berhadapan Dengan Hukum Di Lembaga Pembinaan Khusus Anak Kelas II Jakarta
Authors: Masriah Imas , Budiman Surya , Asri Desy Mulat , Sumarsih Eni , Budianto Jefri Tangkas , Maryanti Ririn , Maida Wahyu 
Published: October 2021

Pengabdian ini berjudul Pendidikan Literasi Keuangan Pada Anak Yang Berhadapan Dengan Hukum Di Lembaga Pembinaan Khusus Anak Kelas II Jakarta. Mengedukasi bagaimana pentingnya pendidikan literasi keuangan pada anak yang berhadapan dengan hukum di LPKA Kelas II Jakarta, bagaiamana penerapan nilai literasi keuangan yang efektif bagi Anak Didik Pemasyarakatan di LPKA Kelas II Jakarta dan peran serta keluarga untuk menanamkan nilai pendidikan literasi keuangan ini bagi Anak Didik Pemasyarakatan di LPKA Kelas II Jakarta. Metode yang digunakan berupa penyuluhan yang dilanjutkan dengan pemberian kuesioner tentang pemahaman pengelolaan keuangan keluarga, serta wawancara.Kata Kunci: Manajemen, Literasi Keuangan Pada Anak, Pengelolaan KeuanganThis service is entitled Financial Literacy Education for Children in Conflict with the Law at the Special Class II Children's Development Institute, Jakarta. Educate on the importance of financial literacy education for children who are in conflict with the law at LPKA Class II Jakarta, how to apply effective financial literacy values for Correctional Students at LPKA Class II Jakarta and the role of families to instill the value of financial literacy education for Correctional Students in LPKA Class II Jakarta. The method used in the form of counseling followed by the provision of questionnaires about the understanding of family financial management, as well as interviews. Keywords: Management; Financial Literacy in Children; Financial Management
abdomen agudo por hernia de amyand
Authors: De la Peña López Jairo , Silgado Kerguelen Ricardo , Calderón Morón Hernán 
Published: October 2021

En el servicio de urgencia se observa con frecuencia la consulta de pacientes con cuadros abdominales de presentación aguda, que ameritan intervención quirúrgica. La apendicitis aguda es la principal patología en orden de frecuencia, sin embargo la presencia de una apendicitis aguda en un saco herniario inguinal incarcerado es poco frecuente. Esta situación clínica es conocida con el nombre de hernia de Amyand. Se presenta caso clínico de un paciente con retardo mental leve, que presentó dolor abdominal con evolución de una semana. Al consultar se evidenció cuadro relacionado con síndrome de respuesta inflamatoria sistémica y características clínicas de abdomen agudo con proceso herniario inguinal derecho incarcerado. En el acto quirúrgico se encontró peritonitis purulenta y un severo proceso adherencial. Se cumplió drenaje de la peritonitis y corrección de la hernia con técnica de Bassini. Rev.cienc.biomed. 2011; 2 (1): 106-110
Fenómeno de Lázaro : retorno de la circulación espontánea después del cese de reanimación cardiopulmonar prolongada en paciente con covid-19.
Authors: Oyola Yepes Antonio José , Martínez Ávila María Cristina , Almanza Hurtado Amilkar José , Trespalacios Sierra Alvano David , Rodríguez Yánez Tomás , Dueñas Castell Carmelo 
Published: October 2021

Introducción: la pandemia por la infección del SARS-CoV-2 o COVID-19 ha impactado de manera inimaginable los sistemas de salud a nivel mundial. La parada cardiorrespiratoria sigue siendo una emergencia médica potencialmente reversible que requiere la realización de un conjunto de maniobras destinadas a sustituir y restaurar la respiración y la circulación espontánea. Suspender una reanimación cardiopulmonar corresponde usualmente a un dilema ético-clínico que debe asumir el profesional de salud a cargo. El “fenómeno de Lázaro” es un síndrome inusual y de difícil explicación fisiopatológica definido como el retorno espontáneo de la circulación en ausencia de cualquier técnica de soporte vital o tras el cese de las maniobras de reanimación cardiopulmonar fallidas. Caso clínico: se presenta el caso de una paciente de 79 años hospitalizada en unidad de cuidados intensivos por choque séptico de origen pulmonar asociado a infección por COVID-19 quien presenta parada cardiorrespiratoria que requirió maniobras de reanimación durante 40 minutos no exitosas, declarada fallecida. Tras 20 minutos del fallecimiento presenta retorno a la circulación espontánea. Conclusión: los cambios fisiopatológicos del fenómeno de Lázaro nos recuerdan las limitaciones que tenemos para determinar cuándo finalizar la reanimación cardiopulmonar y su interrupción debe abordarse con más cuidado, especialmente en el marco de la pandemia de COVID-19.