bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Teamwork, Moral Sensitivity and Missed Nursing Care in ICU Nurses: A Cross‐Sectional Study
Authors: Jia Wanshun , Chen Xue , Fang Jinxia , Cao Heng 
Published: December 2024

ABSTRACTAimTo investigate the correlation between intensive care unit (ICU) nurses' demographic characteristics, teamwork, moral sensitivity and missed nursing care.BackgroundTeamwork, moral sensitivity and missed nursing care are important health challenges among ICU nurses. Clarifying the relationship between variables is benefit to improve the quality of patients care. Nevertheless, a comprehensive conceptualisation of the relationship between teamwork, moral sensitivity and missed nursing care remains lacking.DesignA cross‐sectional design.MethodsThis study follows the STROBE checklist. ICU nurses were recruited by two hospitals between November 2023 and January 2024, in Shandong Province, China. The demographic characteristic questionnaire, teamwork perceptions questionnaire, moral sensitivity questionnaire–revised version into Chinese and the Chinese version of the missed nursing care questionnaire were used for investigation. Multiple linear regression was used to clarify the factors affecting missed nursing care. Pearson correlation was used to test the correlation between teamwork, moral sensitivity and missed nursing care.ResultsThe level of missed nursing care for ICU nurses was low, with overall mean score of 37.49. Missed nursing care for ICU nurses in the labour dispatch were much higher than nurses with the contract system and personnel agency (p < 0.05). The 12‐h shifts of ICU nurses also influenced missed nursing care. Furthermore, teamwork has a positive relationship with moral sensitivity (r = 0.653, p < 0.001).ConclusionHospital and nursing managers should pay attention to the clinical sense of belonging of ICU nurses, reasonably set the working shifts, which will help to reduce the occurrence of missed nursing care.Relevance to Clinical PracticeIt is recommended that nursing managers should invest in strategies to enhance nurse teamwork and implement a 12‐h shift pattern, which can alleviate moral distress and improve quality of care.Patient or Public ContributionNo patient or public contribution. (The data of this were collected from nurses and not related to patients. They were informed of the research process and precautions, signed informed consent.)
Organizational models for advancing technological innovations: A configurational approach
Authors: O'Connor Gina Colarelli 
Published: December 2024

AbstractNovel technologies are emerging and evolving at such a rapid pace that it is difficult for companies and society to absorb them. Large mature organizations can be displaced if they fail to learn about, develop, and adopt new technologies, yet they struggle to do so. What is the best approach? Clearly there is no single best answer. This paper examines organizational models that companies have experimented with for leveraging technological discoveries and inventions to create strategic innovations that fuel new growth opportunities. I adopt Kanter's concept of newstreams as the guiding lens, because it addresses the challenges that mature firms face in their attempts to create new platforms of growth that emerging technologies enable, while maintaining the health of the mainstream core business. This notion demands an extension of ambidexterity theory beyond the exploration/exploitation dichotomy, recognizing that creating new streams of growth that ultimately become part of the mainstream organization requires elements of exploitation to enhance reliability and predictability that the mainstream requires. Five organizational approaches for SI that have been observed in practice are described and considered in light of three elements that, together, can be thought of as comprising a technological innovation strategy: (a) type of ambidextrous approach the firm adopts, (b) type of technology (general vs. special purpose), and (c) targeted market (internal vs. external). By combining theory and observation, configurations of ambidexterity type, technology type, and target market are proposed, as well as expected outcomes for each. I offer these as a research agenda whose outcome can provide important guidance to organizational leaders who are attempting to build capabilities for technological innovation that will secure their organizations' future health.
Molecular characterization of two cyanobacterial generitypes from their type localities in Scandinavia
Authors: Vondrášková Alžběta , Hauer Tomáš , Bengtsson Roland , Kaštovský Jan , Johansen Jeffrey R. 
Published: December 2024

AbstractOver 400 cyanobacterial genera have been described up to the present. Since the Cambridge Rules (https://www.iapt‐taxon.org/historic/1935.htm: Rendle 1935), a type species (generitype) must be specified at the time of description for a new genus to be validly described. Even though we have entered a time in which sequencing has become practical and widespread, the basic molecular characterization (e.g., 16S rRNA gene sequence) of most cyanobacterial generitypes is still lacking. About 15 cyanobacterial genera were originally described from Scandinavia. Following a field excursion in which the type or syntype localities for the type species of these genera were visited and sampled, we succeeded in finding three type species from their type or syntype localities: Capsosira brebissonii, Stigonema mamillosum, and Paracapsa siderophila. Epitypes for all three generitypes are herein established. Cells or filaments of C. brebissonii and S. mamillosum were isolated and used for single‐cell/filament PCR amplification of the 16S rRNA gene and subsequent cloning and sequencing of the PCR amplicons. This allows a firm establishment of reference sequences of these two genera, to which morphologically similar taxa can now be compared. Stigonema and Capsosira are shown herein to be sister to Aetokthonos hydrillicola, a cyanobacterium known to cause avian vacuolar myelinopathy in birds, including bald eagles.
Factors associated with the presence and abundance of Aedes albopictus and Aedes aegypti (Diptera: Culicidae): Perspectives from larval habitat‐scale and neighbourhood‐scale analyses in the Argentine subtropics
Authors: Lizuain Arturo Andres , Maffey Lucia , Leporace Marina , Garzón Maximiliano , Schweigmann Nicolás , Santini María Soledad 
Published: December 2024

AbstractAedes albopictus (Skuse) and Aedes aegypti L. (Diptera: Culicidae) are invasive species known for their notable expansion capacity, which makes them relevant in the context of public health due to their role as vectors. In Argentina, these species coexist in a limited subtropical area in Northeastern part of the country. Because of the limited knowledge existing about these species in this region, the present study aims to investigate the determinants of the presence and abundance of both vectors at the larval habitat scale (presence and abundance) and neighbourhood scale (House, Container and Breteau Indices; abundance; and number of pupae). For this purpose, preimaginal stages of Ae. albopictus and Ae. aegypti were sampled in households from areas with variable urbanisation degrees (in rural, vegetated urban and non‐vegetated urban) located in the province of Misiones, Argentina. The analyses considered the association with meteorological variables (temperature and precipitation), environmental variables (type of urbanisation), biotic variables (presence of predator species) and container characteristics (size and water volume). At the larval habitat scale, Ae. albopictus was associated with precipitation, temperature and rural environments. In contrast, Ae. aegypti was positively associated with urban environments and negatively with predator presence. At the neighbourhood scale, Ae. albopictus was primarily associated with precipitation and temperature, whereas Ae. aegypti showed a negative association with predator presence and positive associations with urban environments and, to a lesser degree, meteorological variables. These results indicate that in Argentina, meteorological, biotic and environmental factors have differential influences on Ae. albopictus and Ae. aegypti, underscoring the need to consider them for the development of effective public health strategies.
Magnetic Resonance Imaging of Gastric Motility in Conscious Rats
Authors: Wang Xiaokai , Alkaabi Fatimah , Cornett Ashley , Choi Minkyu , Scheven Ulrich M. , Di Natale Madeleine R. , Furness John B. , Liu Zhongming 
Published: December 2024

ABSTRACTIntroductionGastrointestinal (GI) magnetic resonance imaging (MRI) enables simultaneous assessment of gastric peristalsis, emptying, and intestinal filling and transit. However, GI MRI in animals typically requires anesthesia, which complicates physiology and confounds interpretation and translation to humans. This study aimed to establish GI MRI in conscious rats, and for the first time, characterize GI motor functions in awake versus anesthetized conditions.MethodsFourteen Sprague–Dawley rats were acclimated to remain awake, still, and minimally stressed during MRI. GI MRI was performed under both awake and anesthetized conditions following voluntary consumption of a contrast‐enhanced test meal.ResultsAwake rats remained physiologically stable during MRI, giving rise to gastric emptying of 23.7% ± 1.4% at 48 min and robust peristaltic contractions propagating through the antrum at 0.72 ± 0.04 mm/s, with a relative amplitude of 40.7% ± 2.3% and a frequency of 5.1 ± 0.1 cycles per minute. Under anesthesia, gastric emptying was approximately halved, mainly due to a significant reduction in peristaltic contraction amplitude, rather than the change in propagation speed, whereas the contraction frequency remained unchanged. Additionally, the small intestine showed faster filling and stronger motility in awake rats.ConclusionThis study demonstrates the feasibility of GI MRI in awake rats and highlights notable differences in gastric and intestinal motility between awake and anesthetized states. Our protocol provides a novel and valuable framework for preclinical studies of GI physiology and pathophysiology.
Effect of Oral Inflammatory Burden on Size and Stage of Oral Tongue Cancer
Authors: Saraneva Orvokki , Furuholm Jussi , Hagström Jaana , Sorsa Timo , Rita Ville , Tervahartiala Taina , Välimaa Hannamari , Ruokonen Hellevi 
Published: December 2024

ABSTRACTObjectiveOral tongue squamous cell carcinoma is an aggressive life‐threatening disease, the prognosis of which is affected by tumor stage and size. We retrospectively studied whether oral inflammatory burden and established tongue carcinoma etiological factors exert an impact on tumor size and stage.Materials and MethodsMedical records of 183 subjects diagnosed with tongue carcinoma at Helsinki University Hospital were investigated. Data on sex, smoking habits, alcohol consumption, and oral inflammatory burden were assessed by the Periodontal Burden Index, Total Dental Index, and Panorama Tomography Index. In addition, Candida hyphae in histological samples, and tumor size and stage were recorded and analyzed. History of oral potentially malignant disorders was also investigated.ResultsIncreased oral inflammatory burden, male sex, and smoking were associated significantly with larger size and advanced stage of cancer, whereas oral Candida hyphae were not associated with size of tongue carcinoma but were associated with female sex.ConclusionMale sex, oral inflammatory burden, and smoking were more common in patients with a large and advanced stage of tongue carcinoma. Thus, oral and periodontal infections and their pro‐inflammatory effects may eventually promote carcinoma growth and advance the stage, especially in males.
Efficacy of Conservative Therapy in Juvenile Recurrent Parotitis: A Retrospective Study
Authors: Li Yanxiang , Niu Shutong , He Zhiyuan , Zhu Hanyi , Liu Yimin , Bao Xin , Yu Chuangqi , Shi Huan 
Published: December 2024

ABSTRACTObjectiveThe objective of this study is to evaluate the therapeutic effect of conservative treatment in children with juvenile recurrent parotitis (JRP).MethodsClinical data from 55 children who were diagnosed with JRP from June 2019 to January 2022 were collected. On admission, patients underwent comprehensive examinations, and a questionnaire was completed by the patients and their parents. Patients received only conservative treatment, including sialagogues, warm compresses, massage and antibiotic treatment.ResultsEpisodes after treatment (1.11 ± 1.42) were significantly lower in 55 patients than before treatment (3.35 ± 2.42) (p < 0.001). Clinical symptoms improved for 81.81% and recurred for 60%. Patients who did not respond to treatment were in 3‐ to 5‐year‐old group. The serum IgG (p = 0.018), IgA (p = 0.014) and IgM (p = 0.032) levels in the nonresponsive group were significantly higher than those in the improvement group and were either higher than the normal range or at the upper limit. The improvement rate was positively related to the CD8%, and the serum IgA concentration was negatively related to the number of previsit episodes.ConclusionConservative treatment is effective for most children with JRP. Patient responses to treatment may be associated with the maturation of their immune systems. Underlying immune dysregulation should be evaluated, and further treatment is needed in severe cases.
The Critical Role of Polyphenols in Immunomodulation and Periodontal Regeneration
Authors: Zhao Mingyu , Li Peitong , Xie Xudong , Shi Peilei , Wang Qianting , Wang Jun , Xu Chunmei 
Published: December 2024

ABSTRACTObjectivesPeriodontitis, the main cause of tooth loss in adults, is a widespread oral disease characterized by chronic inflammation primarily triggered by periodontopathic bacterial infection. Polyphenols are a class of compounds extracted from herbs and diets, characterized by the presence of more than one phenol unit per molecule. Emerging evidence has revealed that polyphenols show significant effectiveness in ameliorating tissue destruction in periodontitis. Herein, we comprehensively review current literature studying the critical role of polyphenols in periodontitis and summarize the predominant molecular mechanisms in immunomodulation and periodontal regeneration, aiming to provide a better understanding of their therapeutic potential in periodontitis.MethodsPubMed and Web of Science databases were searched for articles, reviews, and clinical studies published until August 2024.ResultsWe summarized the immunomodulatory effects of polyphenols in vivo and in vitro, described the research advance regulating the functions of periodontal ligament stem cells and their regeneration potential, and discussed the underlying mechanisms. Finally, we propose future directions for periodontitis therapies with polyphenols.ConclusionsPolyphenols exert a significant anti‐inflammatory effect and promising potential to promote periodontal regeneration. Further study of the molecular mechanisms and techniques to increase the bioavailability and effect of polyphenols is warranted.
Mobile Application‐Based Care on Health Outcomes in Patients With Rheumatoid Arthritis: A Systematic Review and Meta‐Analysis
Authors: Long Manyu , Fu Yingping , Liang Hui , Duan Lingxue , Tie Songyuan , Wang Jing , Wang Shuya 
Published: December 2024

ABSTRACTBackgroundEffective disease management is crucial for rheumatoid arthritis (RA) patients as it can significantly reduce disease‐associated symptoms. Currently, the utilization of mobile applications for managing RA patients has gained widespread popularity in clinical settings. However, there is a notable absence of a comprehensive meta‐analysis exploring their effectiveness specifically in the context of RA patients.ObjectiveThe purpose of our research was to evaluate the effectiveness of mobile app‐based care for patients with rheumatoid arthritis.MethodsWe searched eight databases, including CNKI and PubMed, for randomized controlled trials on the implementation of care for RA patients by mobile apps. This search encompassed a timeframe ranging from the inception of the databases to December 1, 2023. Two researchers reviewed the literature and gathered data based on inclusion and exclusion criteria. The quality of the study was evaluated using the Cochrane Handbook version 5.1.0. The meta‐analysis was carried out using Revman5.4. software.ResultsEight articles encompassing 3175 patients were retrieved for analysis. Over one‐half of the research was from China, duration of the intervention was 6 weeks to 12 months, and eight included studies were of moderate quality. The meta‐analysis revealed that mobile app‐based care was effective in relieving disease activity, relieving pain, and improving patients' quality of life, however, the impact on self‐management was not clear.ConclusionMobile app‐based care has proven effective in reducing disease activity, alleviating joint pain, and improving quality of life in RA patients. Nonetheless, an in‐depth study is recommended to clarify the potential of these interventions for self‐management.Trial Registration: International Prospective Register of Systematic Reviews; Registration number: CRD CRD42024498623.
Recovery From Heroin Addiction: A Qualitative Study
Authors: Krowka Jessica , Aller Loretta 
Published: December 2024

ABSTRACTObjectiveUnderstanding the recovery process from heroin addiction is crucial as nonmedical opioid use persists. This study aims to comprehensively describe the recovery journey, focusing on the experiences and challenges faced by individuals in recovery to inform treatment approaches and support strategies.MethodsThis qualitative study, guided by critical social theory, emphasized balancing power dynamics and fostering equal participation to ensure all voices are heard, challenging traditional hierarchies and promoting inclusivity. Data were collected through audio‐recorded and semi‐structured interviews, and analyzed using Diekelmann's framework. Participants included 10 adults in recovery from heroin addiction, recruited through convenience and snowball sampling methods.ResultsA relational theme “As normal as you can get” was supported by four categories of (a) Being ready: You have to want this; (b) Structure: I need to do certain things through my week and I need to let you know why; (c) Obligation: You realize death was at your door, so many people are dying and you've been granted this gift; and (d) Acceptance: I am who I am today.ConclusionUnderstanding recovery experiences is essential for effective education and support for those at risk of relapse. Insights from this study can help guide the selection of successful treatment and recovery options.
COMMITMENT TO SUSTAINABILITY: A CASE STUDY OF GREEN ENERGY AND SUSTAINABILITY INITIATIVES AT AN AMERICAN UNIVERSITY
Authors: Ilham Zul , Kamaruzuki Muhammad Nazhan 
Published: December 2024

Research, teaching, and involvement at an American university in the areas of green energy and sustainability has placed it at the forefront of international leadership. Its campuses serve as living laboratories for the creation, testing, and implementation of ideas that solve some of the world's most difficult problems. However, very few literatures recorded the approaches made by American universities and most available information are either by European or Asian universities. Therefore, this article aims to provide an overview of the sustainability initiatives that are currently being carried out at this university using the qualitative case study method. We draw from interviews with the stakeholders, documents and observations to capture the information from collective viewpoints that is able to position the views aligned with the ongoing green energy and sustainability initiatives at this university. Some of the key components of this initiative include a realistic goal of Quadruple Bottom Line Sustainability Framework, University Radical Collaboration Priorities in Sustainability and Climate Action Plan. It was discovered from this study that many relatively prominent institutional assets, such as a living laboratory for sustainability and campus activities on wellbeing, played crucial roles in the process of getting the initiative off the ground. In this particular path of development, the initial physical assets have been transformed into complementary potential for research, teaching, and institutional growth. In spite of the fact that the case study is limited to a specific university in a particular geographic location, which makes it difficult to reproduce the findings, it does offer a fresh perspective on the topic of green energy and sustainability adoption by university through the interaction with the stakeholders.
Reactivation of hidden-latent
Brucella
infection after doxycycline and streptomycin treatment in mice
Authors: Sancho-Sánchez Eugenia , García-Arteaga Kimberly , Granados-Chinchilla Fabio , Artavia Graciela , Alfaro-Alarcón Alejandro , Villalobos-Villalobos Andrés , Bouza-Mora Laura , Suárez-Esquivel Marcela , Chacón-Díaz Carlos , Guzmán-Verri Caterina , Moreno Edgardo , Barquero-Calvo Elías 
Published: December 2024

ABSTRACT

Brucellosis has therapeutic challenges due to 3%–15% relapses/therapeutic failures (R/TF) after antibiotic treatment. Therefore, determining the antibiotic concentration in tissues, the physiopathological parameters, and the R/TF after treatment is relevant. After exploring different antibiotic quantities, we found that a combined dose of 100 µg/g of doxycycline (for 45 days) and 7.5 µg/g of streptomycin (for 14 days), respectively, achieved therapeutic levels of more than fourfold minimum inhibitory concentrations (MICs) against
Brucella abortus
in the spleen, liver, bone marrow, and plasma of mice, causing minimal pathophysiological effects. After 30 days of infection, mice received antibiotics, and hematological, histopathological, biochemical, and immunological analyses were performed. After antibiotic therapy, the pathological, hematological, immunological, and physiological profiles paralleled those described in human brucellosis. Treatment lowered antibody titers, reduced proinflammatory cytokines, and reduced inflammation in the target organs for a protracted period. No bacteria were detected in tissues 8 weeks after treatment, suggesting complete recovery. However, despite high doxycycline and streptomycin concentrations in tissues, relapses appeared in 100% of the animals after 182 days post-infection, estimated by the bacterial counts and PCR from organs. This proportion contrasts with the 15% R/TF observed in humans after antibiotic treatments. None of the
B. abortus
isolated from relapses showed augmented MICs or mutations coding for antibiotic resistance in chromosomal-relevant regions. We discuss whether our findings constitute a general phenomenon or differences in the exhaustive screening method for bacteria detection related to the murine model. Along these lines, we envision likely mechanisms of bacterial persistence in tissues after antibiotic treatment.