bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychosocial Aspects of Deliberate Physical Suicide Attempts by Children and Adolescents
Authors: Kinciniene Odeta , Sambaras Rokas , Lesinskaite Auge , Zilinskaite Virginija , Lesinskiene Sigita 
Published: November 2021

Abstract
Background and objectives: Suicide is a topical issue in Lithuania and all around the world. It is the second most common cause of death among young people. There is a lack of research studies on the psychosocial aspects of adolescent suicide in Lithuania. This study aimed to evaluate demographics, life circumstances, and health conditions as factors related to suicide attempt in adolescents. Materials and Methods: A retrospective study was performed at the Children’s Hospital (Vilnius University Santara Clinics). Medical documentation of adolescents treated in this hospital after suicide attempts from January 2011 to April 2018 were analyzed. Results: There were 117 cases of hospitalization due to suicide attempts during this period, and 102 cases were included in the study. There were 83.8% female and 16.2% male patients with an average age of 15.02 ± 1.9 years (p = 0.405); 40.6% of patients lived in divorced families, 17.7% lived in orphanages, 4.2% lived in foster care, 36.4% suffered from parental alcoholism, and 17.2% experienced suicide in their close surroundings. They had comorbidities (girls 72.5%, boys 68.8%), mostly depression (31.3%), were suffering from bullying (54.1%) or violence (26.0%), and 85.4% showed signs of other types of self-harm (girls more often (p < 0.001)). Most of them chose to cut for suicide attempts (86.0% girls, 56.2% boys). In 52.8% of cases, the attempt was spontaneous and 34% relapsed. Thirty-four events occurred in March (18.9%) (p = 0.688).Conclusions: Our study revealed the possible circumstances related to adolescent suicide attempt. Female gender was more common overall and males were more likely to carry out more potentially lethal methods. Other common associated factors were a lack of prosperity in family life, experience of bullying, violence, comorbidities, and the early spring period. Signs of any self-harm could be an indicator of later suicide attempt.
Delivery and Diffusion of Retinal in Dermis and Epidermis Through The Combination of Prodrug Nanoparticles and Detachable Dissolvable Microneedles
Authors: Toprangkobsin Pattrawadee , Banlunara Wijit , Limcharoen Benchaphorn , Leelahavanichkul Asada , Asawanonda Pravit , Kumtornrut Chanat , Sansureerungsikul Titiporn , Rutwaree Teeranut , Wanichwecharungruang Supason 
Published: November 2021

Abstract
To minimize fast chemical degradation of retinal, we convert this aldehyde into proretinal nanoparticles (PRNs) by forming retinylidene moieties on chitosan and allowing the grafted polymers to assemble into nanoparticles, and then load the obtained PRNs into detachable microneedles made of 1:1 (by weight) hyaluronic acid/maltose. An embedment of the PRNs in the solid matrix of microneedles helps improving chemical stability of the grafted retinal; the loaded device can be kept at 25 °C for three months (longest time experimented) with less than 30% degradation of the retinylidene moieties. The presence PRNs in the hyaluronic acid-maltose matrix also help improving mechanical strength of the needles. Administration of PRN-loaded detachable microneedles on fresh porcine ear skin results in complete deposition of an array of microneedles in the skin tissue at the dept that spans both epidermis and dermis, as observed by stereomicroscopic and confocal fluorescence microscopic analyses of the cross-sectioned tissue pieces. Obvious diffusion of the PRNs from the originally embedded site of the needles in the skin tissue to the nearby location can be observed, and even distribution in the tissue is reached at 4 h post administration. Rats administered with single dose of PRN-loaded microneedles show significant increased epidermal thickness as compared to rats administered with unloaded microneedles. Both PRN-loaded microneedles and unloaded microneedles produce no skin irritation in rats.
RETRACTED: Evaluation of Response to Treatment in Breast Cancer-related Lymphedema
Authors: GÜVERCİN EZGİ YILDIZ , EYİGÖR Sibel , Tanigor Göksel , Inbat Menekse , Kabayel Sedef 
Published: November 2021

Abstract

The authors have requested that this preprint be removed from Research Square.
Prognostic Significance of mRNA Expression RBBP8 or its Methylation in Gliomas
Authors: Liu Zhengdong , Cheng Xingbo , Gao Yanzheng , Han Zhibin , Lin Shaochong , Jin Haoran , Luan Zheyu , Li Pengxu , Liang Wenjia , Qian Rongjun 
Published: November 2021

Abstract
Retinoblastoma-binding protein 8 (RBBP8) affects the prognosis of patients with malignancies through various mechanisms. However, its function in gliomas is unknown. Our study explored the effects of RBBP8 on the prognosis of glioma patients, as well as its regulatory role in the glioma immune microenvironment. We used various bioinformatics methods to analyze the transcriptional profiles and methylation data of RBBP8 in gliomas from multiple databases. Our results showed that the mRNA and protein expression of RBBP8 in gliomas was higher than that in normal tissues and positively correlated with malignant clinical features such as age and WHO grade. A Kaplan–Meier analysis showed that patients with high RBBP8 expression had a poor prognosis. Cox regression demonstrated that RBBP8 was an independent risk indicator and had good diagnostic value for the poor prognosis of glioma. A meta-analysis confirmed the carcinogenic effect of RBBP8 on glioma, while the Tumor Immune Estimation Resource analysis showed that RBBP8 was positively correlated with the infiltration of six immune cell types in low-grade glioma, but only with dendritic cells in glioblastoma multiforme. Importantly, RBBP8 was positively correlated with many well-known immune checkpoints (e.g., CTLA4 and PDL-1). Finally, a gene set enrichment analysis revealed that RBBP8 can promote the activation of cancer-related pathways such as cell cycle, DNA replication and so on. In conclusion, this study is the first to elaborate on the value of RBBP8 in the pathological process of glioma for anti-tumor immunotherapy. In addition, the expression of RBBP8 and its methylation site, cg05513509, may provide potential targets for glioma therapy.
Evaluation and Selection of Potent Fluorescent Immunosensors by Combining Fluorescent Peptide and Nanobodies Displayed on Yeast Surface
Authors: Inoue Akihito , Yasuda Takanobu , Zhu Bo , Kitaguchi Tetsuya , Murakami Akikazu , Ueda Hiroshi 
Published: November 2021

Abstract
Quenchbody (Q-body) is a quench-based fluorescent immunosensor labeled with fluorescent dye(s) near the antigen-binding site of an antibody. Q-bodies can detect a range of target molecules rapidly and directly. However, because Q-bodies show different antigen responses depending on the antibody used, time-consuming optimization of the Q-body structure is often necessary, and a high-throughput screening method for discriminating and selecting good Q-bodies is required. Here, we aimed to develop a molecular display method of nanobody-based “mini Q-bodies” by combining yeast surface display and coiled-coil forming E4/K4 peptide-based fluorescence labeling. As a result, the yeast-displayed mini Q-body recognizing the anti-cancer agent methotrexate (MTX) showed significant quenching and MTX-dependent dequenching on cells. To demonstrate the applicability of the developed method to select highly responsive mini Q-bodies, a small nanobody library consisting of 30 variants that recognize human serum albumin was used as a model. The best variant, showing a 2.4-fold signal increase, was obtained through selection by flow cytometry. Furthermore, the same nanobody prepared from Escherichia coli also worked as a mini Q-body after dye labeling. The described approach will be applied to quickly obtain well-behaved Q-bodies and other fluorescent biosensors for various targets through directed evolutionary approaches.
How Does Biased Technological Progress Affect Haze Pollution? Evidence from APEC Economies
Authors: Yang Guanglei , Zha Donglan 
Published: November 2021

Abstract
Biased technological progress is the act of energy conservation and emission reduction by changing the marginal rate of substitution. In this study, we introduced renewable energy into a production function, and proposed a method of identifying biased characteristics of technological progress, based on marginal productivity theory. A panel dataset for the Asia-Pacific Economic Cooperation (APEC) economies from 2000-2017 was analyzed to explore the effect of biased technological progress in reducing particulate matter (PM2.5). We found that input biased technological progress tended to use more non-renewable energy. Input biased technological progress aggravated haze pollution; however, this effect decreased as the PM2.5 concentration increased. Output biased technological progress significantly reduced haze pollution in high-income economies, but increased it in low-income economies. The effect of neutral technological progress on haze pollution was the opposite of the effect from output biased technological progress. We also found that increasing renewable energy consumption and reducing energy intensity were separate effective paths for input and output biased technological progress, respectively, to mitigate haze pollution. For neutral technological progress, improving total factor productivity was an important way to mitigate haze pollution. Finally, several policy recommendations are proposed to mitigate haze pollution in APEC economies.
Improving 1-propanol Force Field: a New Methodology
Authors: Alva-Tamayo José Abundio Daniel , Guillén-Escamilla Iván , Méndez-Maldonado Gloria Arlette , Méndez-Bermúdez José Guillermo 
Published: November 2021

Abstract
A new force field for 1-propanol, in the united and all atom models, has been obtained by combining two different empirical methodologies. The first was developed by scaling atom charges, and Lennard-Jones parameters to fit the dielectric constant, surface tension, and density ((2018) J. Chem. Theory Comput. 14:5949-5958). The second methodology consists of moving these parameters and together with the bond distance to obtain the liquid-vapor phase diagram of the CO2 molecule ((1995) J. Phys. Chem. 99:12021-12024). The last methodology is used to obtain the self-diffusion coefficient, which was not considered in the first one. With this new methodology, the experimental density, dielectric constant, surface tension, and self-diffusion coefficient at ambient temperature could be achieved. Furthermore, we show the temperature dependence of the aforementioned properties. The static structure factors are in accordance with the experimental spectrum. Solubility is increased to the experimental value for the united atom model after applying this methodology and for all atom scheme, the experimental solubility value is maintained.
Happiness and Hope for Success in T1DM Patients
Authors: Cyranka Katarzyna , Dudek Domnika , Matejko Bartłomiej , Małecki Piotr , Małecki Maciej T , Pilecki Maciej , Klupa Tomasz 
Published: November 2021

Abstract
Happiness and hope are essential parts of human health. One of the main purposes of health care, including diabetes care, are to achieve happiness and a sense of purpose in life. Material and methodDuring educational workshops a short survey concerning the level of happiness and hope for success in the group of Type 1 Diabetes Mellitus (T1DM) patients was carried out. 120 patients anonymously filled in Subjective Happiness Scale (SHS) and a Hope for Success Questionnaire (KNS).Results and conclusionsThe level of subjective happiness in T1DM patients was lower than in general population for both sexes, for all age categories apart from people older than 50, who seem to be happy and satisfied with their life with no differences compared to the general population. In terms of hope for success, T1DM teenagers and adults aged 27-50 did not differ from the general population. T1DM patients older than 50 turned out to have higher hope for success in life that other T1DM patients. Special attention should be paid to patients in young adulthood (18-26), who seem to be the most pessimistic group of T1DM patients, with low self-esteem and low believe in their possibilities.
Environmental Regulation, Innovation Capability, and Green Total Factor Productivity: New Evidence from China
Authors: Lee Chien-Chiang , Zeng Mingli , Wang Changsong 
Published: November 2021

Abstract
In recent years, China's economy has experienced a rapid transformation period from rugged economic development to a sustainable economic development style. Increasing green total factor productivity (GTFP) is considered as one of the important signs. The application of innovation capability (ICY) is becoming more and more widely used in modern life. But it is still unclear how ICY can affect GTFP. With increasingly stricter environmental laws and regulations, how environmental regulations (ER) affect GTFP is unclear. This research contributes to the literature on the impact mechanisms of ICY and ER on GTFP using the data on 30 Chinese provinces covering the period from 2006-2017. The results indicate both ICY and ER can effectively promote GTFP. Compared with ER, ICY has obvious heterogeneity on GTFP, that is, the stronger the ICY is, the stronger it promoting effect on GTFP. Next, ICY plays an intermediary role in ER and GTFP, and ER can promote GTFP through ICY. Accordingly, the paper puts forward some policy suggestions, such as optimizing and improving ER policy, unswervingly practicing innovation-driven development strategy, strengthening monitoring and supervision.
Impact of COVID-19 on Delays in General Practice. A Retrospective Analysis
Authors: Schers Henk , Boven Kees van , Akkermans Reinier , Weel Chris van , Hartman Tim olde , Bischoff Erik 
Published: November 2021

Abstract
BackgroundFrom the beginning of the COVID-19 pandemic, worries have been exposed about collateral damage to patients’ health through postponed appointments, and delayed diagnostic testing and referrals in general practice.AimTo study delays in presentation and management of health problems in general practice during the first 9 months of the COVID-19 crisis. We aimed at symptoms that were most relevant: COVID-19 related symptoms, cancer-related symptoms, mental health symptoms, and musculoskeletal symptoms. Design and settingRetrospective analysis of routine patient data from a practice based registration network in the Netherlands (population 40.000 patients; 30 GPs).MethodWe compared data from the first nine months of the COVID-19 crisis to the preceding 5 years, and analyzed differences between the periods of time in the duration of symptoms before presentation, and the duration from the first presentation in general practice until diagnostic testing and referrals.ResultsWe found no indications that patients waited longer to contact the FP for newly presented health symptoms; only COVID-19 related symptoms were presented earlier to family practice (p< 0.001). Also, we found no delays in general practice for diagnostic testing or referring to hospital care in 2020.ConclusionsGeneral practice maintained its capability to deliver timely care for newly presented health symptoms during the COVID-19 crisis, despite serious changes in delivery modes: patients have contacted their GPs broadly when it was needed, and do not seem to have postponed their help seeking behavior massively. Follow-up studies are needed to monitor long term consequences also in other health echelons.
The Association between BMI and Osteoarthritis in Adults
Authors: Liu Zheling , Zheng Liwen , Xu Liguang 
Published: November 2021

Abstract
Objectives: The prevalence of obesity-related symptomatic OA has been found to increase. We investigated the relationship between BMI and osteoarthritis in 14,058 20-85 year-old participants from the National Health and Nutrition Examination Survey (NHANES). Methods: To estimate the association between BMI and osteoarthritis, multivariate logistic regression analyses were conducted. Fitted smoothing curves. Results: After adjusting for other confounding factors, we found that BMI was positively correlated with osteoarthritis. On subgroup analyses, stratified by sex and race/ethnicity, the positive correlation between BMI and Osteoarthritis in men and women, as well as in whites, blacks, and Mexican Americans, still exists. Conclusions: Our study revealed a positive relationship between BMI and Osteoarthritis in most adults.
Tunneling between parallel one-dimensional Wigner crystals
Authors: Mendez-Camacho Reyna , Cruz-Hernandez Esteban 
Published: November 2021

Abstract
Vertically aligned arrays are a frequent outcome in the nanowires synthesis by self-assembly techniques or in its subsequent processing. When these nanowires are close enough, quantum electron tunneling is expected between them. Then, because extended or localized electronic states can be established in the wires by tuning its electron density, the tunneling configuration between adjacent wires could be conveniently adjusted by an external gate. In this contribution, by considering the collective nature of electrons using a Yukawa-like effective potential, we explore the electron interaction between closely spaced, parallel nanowires while varying the electron density and geometrical parameters. We find that, at a low-density Wigner crystal regime, the tunneling can take place between adjacent localized states along and transversal to the wires axis, which in turn allows to create two- and three-dimensional electronic distributions with valuable potential applications.
Spatiotemporal Heterogeneities and Driving Factors of Water Quality and Trophic State of a Typical Urban Shallow Lake (Taihu, China)
Authors: Wang Yonggui , Guo Yanqi , Zhao Yanxin , Wang Lunche , Chen Yan , Yang Ling 
Published: November 2021

Abstract
Water quality deterioration and eutrophication of urban shallow lakes are global ecological problems with increasing concern and greater environmental efforts. In this study, spatiotemporal changes of water quality and eutrophication over 2015-2019 in Lake Taihu, were assessed using the monthly time series of 7 water quality parameters measured at 17 sites. The whole lake was divided into 7 sub-lakes and trophic condition was evaluated by trophic level index (TLI). Taihu had poor water quality overall which was mainly astricted by the total nitrogen (TN) and the total phosphorus (TP) and maintained a light-eutropher state, but it had improved in the last five years. It is found that all nutrient parameters reached relatively higher concentrations in the northwestern and northern Taihu with combined cluster analysis and spatial interpolation methods. Meiliang Bay was the most polluted and nutrient-rich area. Mann-Kendall test highlighted the fact that the TP and chlorophyll-a (Chl-a) concentrations increased significantly while the TN and five-day biochemical oxygen demand (BOD5) decreased. The nutrient loading input from the northwestern areas with high human activity and the geomorphological characteristic of the northern closed bays were the main contributors to the spatial heterogeneity in water quality. The main driving force of N pollution was the declining river inflow N loading. And P pollution was affected more by accumulated endogenous pollution, decline aquatic plants area, as well as closely linked with algae biomass. Further water pollution and eutrophication mitigation of Taihu should focus on the limitation of algae and those heavily polluted closed bays.
Security Enhancement and PaaS platform Authentication in Cloud Computing based On SBA
Authors: Vankdothu Ramdas , Hameed Mohd Abdul 
Published: November 2021

Abstract
One of the most challenging security requirements in a PaaS platform setting is authentication. We provide a new signature-based authenticated key establishment approach for PaaS platform security improvement in this study. It adds a feature to increase confidentiality and non-repudiation by requiring the sender to sign a specific action while sending data from one user to another. It’s signed with the transaction’s private key and a public-key value-based signature generated with the transaction’s public key. Use the public key value-based signature that was generated to authenticate this operation, and the hashing process assures that the operation is immutable. Our proposed solution delivers improved data security, throughput, reaction speed, and a reduction in end-to-end delay and overhead when compared to existing methodologies. The results of the experiments reveal that the proposed system achieves a superior outcome to the existing methods. This project makes use of the MATLAB platform.
Erosion potential of ultrasonic food processing
Authors: Bredihin Sergei , Andreev Vladimir , Martekha Alexander , Schenzle Matthias , Korotkiy Igor 
Published: November 2021

Introduction. Cavitation is the most significant factor that affects liquid food products during ultrasound treatment. Ultrasonic treatment intensifies diffusion, dissolution, and chemical interactions. However, no physical model has yet been developed to unambiguously define the interaction between ultrasonic cavities and structural particles of liquid food media. Physical models used to describe ultrasonic interactions in liquid food media are diverse and, sometimes, contradictory. The research objective was to study ultrasonic devices in order to improve their operating modes and increase reliability.
Study objects and methods. The present research featured ultrasonic field generated in water by the cylindrical emitter, the intensity of flexural ultrasonic waves and their damping rate at various distances from the emitter.
Results and discussion. The paper offers a review of available publications on the theory of acoustic cavitation in various media. The experimental studies featured the distribution of cavities in the ultrasound field of rod vibrating systems in water. The research revealed the erosion capacity of ultrasonic waves generated by the cylindrical emitter. The article also contains a theoretical analysis of the cavitation damage to aluminum foil in water and the erosive effect of cavitation on highly rigid materials of ultrasonic vibration systems. The obtained results were illustrated by semi-graphical dependences.
Conclusion. The present research made it possible to assess the energy capabilities of cavities generated by ultrasonic field at different distances from the ultrasonic emitter. The size of the contact spot and the penetration depth can serve as a criterion for the erosion of the surface of the ultrasonic emitter.