bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGEMBANGAN LEMARI PENGERING HERBARIUM DENGAN DEHUMIDIFIER DI LABORATORIUM BIOLOGI, UNIVERSITAS BENGKULU
Authors: Susanto Dedi , Edwar Edwar 
Published: December 2021

Salah satu kegiatan utama di Laboratorium Biologi adalah pembuatan spesimen herbarium tanaman kering. Kegiatan pembuatan herbarium dilakukan baik dalam kegiatan praktikum maupun penelitian yang dilakukan oleh dosen dan mahasiswa. Di Laboratorium Biologi, pembuatan herbarium dilakukan dengan menggunakan oven sebagai alat pengering. Sementara, saat ini di Laboratorium Biologi subLab Botani hanya terdapat 1 unit oven berkapasitas 60 liter. Hal ini menjadi salah satu hambatan pelayanan subLab Botani pada kegiatan praktikum dan penelitian, di mana ketika dilaksanakan pembuatan herbarium baik oleh kegiatan praktikum maupun oleh kegiatan penelitian terjadi waktu-tunggu yang cukup lama karena keterbatasan jumlah alat pengering yang ada. Hambatan menjadi semakin besar ketika di waktu bersamaan dilaksanakan kegiatan praktikum atau penelitian lain yang membutuhkan oven juga. Solusi utama dari permasalahan ini adalah pengadaan oven yang baru, namun ini bukan hal yang mudah terlaksana karena harga oven laboratorium berkapasitas besar relatif mahal. Selain itu kapasitas oven yang hanya sekira 60 L hanya mampu menampung sejumlah kecil spesimen tanaman dalam satu kali proses pengeringan. Karena itulah, penulis berupaya mencari solusi alternatif dengan merancang lemari pengering yang memiliki kapasitas muat 2x dari oven yang selama ini telah digunakan. Sebagai alat pengering digunakan paduan dari alat-dehumifier (sebagai penyerap uap air) dan kipas (sebagai pengatur sirkulasi udara).
Factores de riesgo de anemia ferropénica en niños menores de un año
Authors: Gongora-Ávila Cesar Ramón , Mejias-Arencibia Roberto Alejandro , Vázquez-Carvajal Lisandra , Álvarez Hernández José Carlos , Frías Pérez Annalie Elizabeth 
Published: December 2021

Objetivo: identificar los factores de riesgo de anemia ferropénica en niños menores de un año pertenecientes al Policlínico Docente "7 de Noviembre" del municipio Majibacoa durante el año 2020.
Métodos: estudio observacional, descriptivo, de corte transversal en lactantes menores de un año con anemia ferropénica pertenecientes al Policlínico Docente "7 de Noviembre" del municipio Majibacoa durante el año 2020. El universo estuvo constituido por 42 niños menores de un año con anemia ferropénica; se trabajó con la totalidad de estos. Se analizaron las variables: edad, sexo, intensidad de la anemia, factores de riesgo biológicos y factores de riesgo sociales y culturales.
Resultados: el 61,9 % eran del sexo femenino; por su parte la edad más representada fue la menor de 6 meses en ambos sexos, aunque más observada en las féminas (33,3 %). el 61,9 % tenían anemia ligera. El 69,0 % de las madres con anemia gestacional sus hijos presentaron anemia ferropénica; por otra parte, el 47,6 % de los niños menores de un año tenían como antecedente el abandono de la lactancia materna exclusiva.
Conclusiones: el antecedente de anemia durante la gestación, el bajo peso al nacer, la ablactación incorrecta y el abandono de la lactancia materna exclusiva constituyen los principales factores de riesgo en el origen de la anemia ferropénica en niños menores de un año.
IRONIC ΗRYHIR TIUTIUNNYK (SOME OBSERVATIONS)
Authors: Moroz Larysa 
Published: December 2021

One of the most dramatic writers of the 2nd half of the 20th century Hryhir Tiutiunnyk was remembered by all his contemporaries who worked in the cultural sphere as a person endowed with a keen sense of humor, rare wit, and unique artistry (in various genres, both dramatic and comedic). This paper is a reflection on how in the works by Hryhir Tiutiunnyk, killed by the totalitarian system in 1980, the well-known dominants of “love and pain” are deepened by irony, in all the immensity of its shades and meanings. The writer did not use any words from the political lexicon but instead unmasked the totalitarian system by depicting (mostly through apt expressions and details) the behavior and destinies of people oppressed or destroyed by it. His irony is mild, lenient, or even somewhat sympathetic. In the stories reviewed in the paper, namely “Screw”, “Niura”, “The Feast in Memory of Markiian”, “The Son Has Arrived”, the mentioned nuances of the means of irony are used in rather complex, sometimes weird combinations (“The Literate”, “Laughter”), revealing the ardent indifference of the author who tried (sometimes successfully) to pretend to be an outsider – an unworried or even superior narrator. In such works as “The Feast in Memory of Markiian” and “Medal”, the death itself or its obvious approach causes the appearance of tragicomic elements. However, in the latter, the tragic irony is not related to the character, but to the props of the stage action, in which the people resembling mannequins represent the village and district authorities and pretend to award a starving man as “the best animal breeder”.
Some of Hryhir Tiutiunnyk’s characters, as in the short story “Oddity” and the story “My Saturday”, rise to a sarcastic mockery of oppressors: the specificity of the Soviet-communist officials lies in the fact that they don’t even realize the absurdity of their activities, which lack any humanistic principles. The literary world of the writer, despite its seeming simplicity, is extremely complex in terms of inner subtleties of thoughts, emotions, and conflicts.
INTERMEDIAL RECODING OF GEO SHKURUPII'S WORKS IN THE VIDEO PERFORMANCES AT THE SEMINAR OF CREATIVE YOUTHS 2020
Authors: Gladun Daryna 
Published: December 2021

The paper focuses on poetry-based video performances conducted by the participants of the “Creative Youths Seminar” (CYS), which was founded in 1995. Adaptability is one of the most essential features of all seminar clusters. It leads to constant transformations in a general program and within poetry performance laboratory (existing as a part of CYS since 2015) in particular, due to socio-cultural and political context. In 2020, because of the quarantine restrictions, CYS for the first time changed its regular face-to-face form to a remoteone and took place online. Live performance cluster transformed into a three-day marathon of video performances. During that time 24 participants made over 70 video performances that lasted for more than 100 minutes in total (there was a record number in every category of a CYS performance cluster). Nearly half of the performances were poetry-based. Almost a third part was based on the poems by Ukrainian Futurist writers Oleksa Vlyzko, Mykhail Semenko, Oleksa Slisarenko, Andrii Chuzhyi, Geo Shkurupii, and Yulian Shpol. The article analyzes five poetry-based video performances that refer to the poems by Geo Shkurupii as pretexts: “A Talk with a Future Self ” by Yaroslav Boruta, “I Want to Be a Furniture” by Vladyslava Demianchuk (Dadi), “Oh Little Boy” by Natalia Matsybok-Starodub, “Czech Scotch Tape” by Iryna Pavlenko (Ira Pamiatai), and “The Future of Cherry Orchards” by Viktoriia Feshchuk. The pretexts, poetry performance texts (if any), and their intermedial connections with video performances have been examined.
The researcher concludes that poetry-based performances let the artists not only experience the text traditionally but also ‘live through the text’, or, in other words, create a personal physical experience of the pretext and offer the audience another perspective on the pretext with the help of non-literary media.
EXPERIMENTAL STUDY ON BEHAVIOR OF UNPROTECTED FOAMED CONCRETE FILLED STEEL HOLLOW COLUMN UNDER FIRE
Authors: Kado Bishir , Mohammad Shahrin , Lee Yeong Huei , Shek Poi Ngian , Ab Kadir Mariyana Aida 
Published: December 2021

Reduction in self-weight and achievement of full fire resistance requirements are some of the important considerations in the design of high-rise structures. Lightweight concrete filled steel tube (CFST) column provides an alternative method to serve these purposes. Recent studies on lightweight CFST columns at ambient temperature have revealed that foamed concrete can be a beneficial and innovative alternative material. Hence, this study investigates the potential of using foamed concrete in circular hollow steel columns for improving fire resistance. A series of nine fire test on circular unfilled hollow and foamed concrete filled hollow section column were carried out. ISO 834 standard fire exposure test were carried out to investigate the structural response of these columns under fire. The main parameters considered are load level and foamed concrete density; foamed concrete density used are 1500 kg/m3 and 1800 kg/m3 at 15%, 20%, and 25% load level. All the columns tested are without any external fire protection, with concentrically applied load under fixed-fixed boundary conditions. The columns dimension was 2400 mm long, 139.7 mm diameter and steel tube thickness of 6 mm. The fire test result showed that foamed concrete increases the fire resistance of steel hollow column up to an additional 16 minutes. The improvement is more at load level above 15%, and the gain in fire resistance is about 71% when 1500 kg/m3 density foamed concrete is used. Generally, foamed concrete filled steel hollow column demonstrate a good structural fire behavior, based on the applied load and foamed concrete density. Also, inward local buckling was averted by filling the steel hollow column with foamed concrete. General method for composite column design in Eurocode 4 adopted to calculate the axial buckling load of 1500 kg/m3 foamed concrete filled columns. These type of columns can be used for structures like airports, schools, and stadiums; taking the advantage of exposed steel for aesthetic purpose and high fire resistance. It can also be used for high rise structures; taking advantage of high fire resistance and reduction in self-weight of a structure.
Photoluminescence-Based Bioassay With Cysteamine-Capped TiO2 Nanoparticles for the Selective Recognition of N-Acyl Homoserine Lactones
Authors: Vasudevan Sahana , Srinivasan Parthasarathy , Neelakantan Prasanna , Rayappan John Bosco Balaguru , Solomon Adline Princy 
Published: December 2021

Currently available diagnostic procedures for infections are laborious and time-consuming, resulting in a substantial financial burden by increasing morbidity, increased costs of hospitalization, and mortality. Therefore, innovative approaches to design diagnostic biomarkers are imperative to assist in the rapid and sensitive diagnosis of microbial infections. Acyl homoserine lactones (AHLs) are ubiquitous bacterial signaling molecules that are found to be significantly upregulated in infected sites. In this pioneering work, we have developed a simple photoluminescence-based assay using cysteamine-capped titanium oxide (TiO2) nanoparticles for AHL detection. The PL intensity variation of the oxygen defect state of TiO2 was used for the biosensing measurements. The bioassays were validated using two well-studied AHL molecules (C4-HSL and 3-oxo-C12 HSL) of an important human pathogen, Pseudomonas aeruginosa. The developed system has a maximum relative response of 98%. Furthermore, the efficacy of the system in simulated host urine using an artificial urine medium showed a linear detection range of 10–160 nM. Also, we confirmed the relative response and specificity of the system in detecting AHLs produced by P. aeruginosa in a temporal manner.
Association Between Heart Rate and Major Adverse Cardiovascular Events Among 9,991 Hypertentive Patients: A Multicenter Retrospective Follow-Up Study
Authors: Sun Ningling , Chen Yuanyuan , Xi Yang , Wang Hongyi , Wang Luyan 
Published: December 2021

Objective: To assess the effect of heart rate at baseline on major adverse cardiovascular events (MACEs) among hypertensive patients in China.Methods: A multicenter retrospective study was conducted with a 24 month follow-up period. A total of 10,031 hypertensive patients treated with standard antihypertensive drugs were grouped according to their heart rate before treatment: &lt;65 beats per min (bpm), 65–69 bpm, 70–74 bpm, 75–79 bpm, and ≥80 bpm. The occurrence of any of MACEs was as the endpoint event during the 24 month follow-up period. The effect of heart rate at baseline on MACEs was analyzed using univate and multivariable Cox proportional regression analyses, with hazard ratios (HRs) and 95% confidence intervals (CIs). The restricted cubic spline (RCS) model was used to fit the Cox proportional harzard model with 5 knots at the 5th, 25th, 50th, 75th, and 95th percentiles of heart rate.Results: Totally 9,991 patients were finally enrolled with the mean systolic pressure (SBP)/diastolic pressure (DBP) of 130.59 ± 7.13/77.66 ± 5.99 mmHg at 24 month follow-up. The incidence of MACEs was 4.80% (n = 480). After adjustment for age, gender, baseline blood pressure, alcohol drinking, smoking, hyperlipidemia, diabetes, coronary heart disease, cerebrovascular disease and antihypertensive drug use, patients with heart rate &lt;65 bpm (HR = 1.450, 95% CI: 1.098–1.915) and ≥80 bpm (HR = 1.391, 95% CI: 1.056–11.832) showed 0.45 fold and 0.391 fold increases of MACE risks, compared with patients with heart rate of 70–74 bpm. Furthermore, MACE risks were increased by 86.0% and 65.4% in men, and 59.3% and 69.0% in elderly patients aged ≥65 years at heart rate &lt;65 bpm or ≥80 bpm, respectively. We also found a non-liner U-shaped correlation between heart rate and the occurrence of MACEs.Conclusions: Heart rate might be an independent risk factor for MACEs in hypertensive patients. An appropriate range of heart rate control may offer guidance to hypertension treatment.
Fulminant Giant Cell Myocarditis vs. Lymphocytic Myocarditis: A Comparison of Their Clinical Characteristics, Treatments, and Outcomes
Authors: Hu Yuxiao , Ren Jie , Dong Xueqi , Zhang Di , Qu Yi , Yang Chunxue , Sun Yang , Li Jinghui , Luo Fang , Wang Wei , Wang Huanhuan , Qing Ping , Zhao Shihua , Huang Jie , Yu Litian , Liu Yaxin , Tan Huiqiong 
Published: December 2021

Objectives: Fulminant myocarditis (FM) is a rapidly progressive and frequently fatal form of myocarditis that has been difficult to classify. This study aims to compare the clinical characteristics, treatments and outcomes in patients with fulminant giant cell myocarditis (FGCM) and fulminant lymphocytic myocarditis (FLM).Methods and Results: In our retrospective study, nine patients with FGCM (mean age 47.9 ± 7.5 years, six female) and 7 FLM (mean age 42.1 ± 12.3 years, four female) patients confirmed by histology in the last 11 years were included. Most patients with FGCM and FLM were NYHA functional class IV (56 vs. 100%, p = 0.132). Patients with FGCM had significantly lower levels of high-sensitivity C-reactive protein [hs-CRP, 4.4 (2.0–10.2) mg/L vs. 13.6 (12.6–14.6) mg/L, P = 0.004, data shown as the median with IQR], creatine kinase-myoglobin [CK-MB, 1.4 (1.0–3.2) ng/ml vs. 14.6 (3.0–64.9) ng/ml, P = 0.025, median with IQR], and alanine aminotransferase [ALT, 38.0 (25.0–61.5) IU/L vs. 997.0 (50.0–3,080.0) IU/L, P = 0.030, median with IQR] and greater right ventricular end-diastolic diameter (RVEDD) [2.9 ± 0.3 cm vs. 2.4 ± 0.6 cm, P = 0.034, mean ± SD] than those with FLM. No differences were observed in the use of intra-aortic balloon pump (44 vs. 43%, p = 1.000) and extracorporeal membrane oxygenation (11 vs. 43%, p = 0.262) between the two groups. The long-term survival rate was significantly lower in FGCM group compared with FLM group (0 vs. 71.4%, p = 0.022). A multivariate cox regression analysis showed the level of hs-CRP (hazard ratio = 0.871, 95% confidence interval: 0.761–0.996, P = 0.043) was an independent prognostic factor for FM patients. Furthermore, the level of hs-CRP had a good ability to discriminate between patients with FGCM and FLM (AUC = 0.94, 95% confidence interval: 0.4213–0.9964).Conclusions: The inflammatory response and myocardial damage in the patients with FGCM were milder than those with FLM. Patients with FGCM had distinctly poorer prognoses compared with those with FLM. Our results suggest that hs-CRP could be a promising prognostic biomarker and a hs-CRP level of 11.71 mg/L is an appropriate cutoff point for the differentiating diagnosis between patients with FGCM and FLM.
A Population-Based Systematic Clinical Analysis With a Single-Center Case Series of Patients With Pulmonary Large Cell Neuroendocrine Carcinoma
Authors: Sun Xu , Wu Yijun , Shen Jing , Han Chang , Kang Kai , Liu Zhikai , Zhang Fuquan 
Published: December 2021

Background and ObjectivesThis study aims to conduct an updated systematic analysis of patients with pulmonary large cell neuroendocrine carcinoma (PLCNC) in recent decades, concerning incidence and mortality trends, demographics, treatments, survival and death causes.MethodsPatients who were diagnosed with PLCNC at the Peking Union Medical College Hospital (PUMCH) between 2000 to 2020 were retrospectively analyzed. The population-based Surveillance, Epidemiology, and End Results (SEER) database were also retrieved. Frequencies and average annual age-adjusted rates (AAR) of PLCNC patients were calculated and analyzed by Joint-point regression. Univariate and multivariate Cox regression were used for identifying prognostic factors. Predictive nomograms for overall survival (OS) and cancer-specific survival (CSS) were developed and then validated by calculating C-index values and drawing calibration curves. Survival curves were plotted using the Kaplan-Meier method and compared by log-rank test. Causes of death were also analyzed by time latency.ResultsA total of 56 PLCNC patients of the PUMCH cohort were included. Additionally, the PLCNC patients in the SEER database were also identified from different subsets. The AAR from 2001 to 2017 were 3.21 (95%CI: 3.12-3.30) per million. Its incidence and mortality rates in PLCNC patients increased at first but seemed to decline in recent years. Besides TNM stage and treatments, older age and male gender were independently associated with poorer survival, while marital status only affected CSS other than OS. The nomograms for OS and CSS presented great predictive ability and calibration performance. Surgery gave significantly more survival benefits to PLCNC patients, and chemotherapy might add survival benefits to stage II-IV. However, radiation therapy seemed to only improve stage III patients’ survival.ConclusionsThis study supported some previous studies in terms of incidence, survival, and treatment options. The mortality rates seemed to decline recently, after an earlier increase. Among PLCNC patients, most of the deaths occurred within the first five years, while other non-PLCNC diseases increased after that. Thus, careful management and follow-up of other comorbidities are of equal importance. Our study may partly solve the dilemma caused by PLCNC’s rarity and inspire more insights in future researches.
Prognostic Implications and Immune Infiltration Analysis of ALDOA in Lung Adenocarcinoma
Authors: Lu Guojun , Shi Wen , Zhang Yu 
Published: December 2021

Background: aldolase A (ALDOA) has been reported to be involved in kinds of cancers. However, the role of ALDOA in lung adenocarcinoma has not been fully elucidated. In this study, we explored the prognostic value and correlation with immune infiltration of ALDOA in lung adenocarcinoma.Methods: The expression of ALDOA was analyzed with the Oncomine database, the Cancer Genome Atlas (TCGA), and the Human Protein Atlas (HPA). Mann-Whitney U test was performed to examine the relationship between clinicopathological characteristics and ALDOA expression. The receiver operating characteristic (ROC) curve and Kaplan-Meier method were conducted to describe the diagnostic and prognostic importance of ALDOA. The Search Tool for the Retrieval of Interacting Genes (STRING) and Cytoscape were used to construct PPI networks and identify hub genes. Functional annotations and immune infiltration were conducted.Results: The mRNA and protein expression of ALDOA were higher in lung adenocarcinoma than those in normal tissues. The overexpression of ALDOA was significantly correlated with the high T stage, N stage, M stage, and TNM stage. Kaplan-Meier showed that high expression of ALDOA was correlated with short overall survival (38.9 vs 72.5 months, p &lt; 0.001). Multivariate analysis revealed that ALDOA (HR 1.435, 95%CI, 1.013–2.032, p = 0.042) was an independent poor prognostic factor for overall survival. Functional enrichment analysis showed that positively co-expressed genes of ALDOA were involved in the biological progress of mitochondrial translation, mitochondrial translational elongation, and negative regulation of cell cycle progression. KEGG pathway analysis showed enrichment function in carbon metabolism, the HIF-1 signaling pathway, and glycolysis/gluconeogenesis. The “SCNA” module analysis indicated that the copy number alterations of ALDOA were correlated with three immune cell infiltration levels, including B cells, CD8+ T cells, and CD4+ T cells. The “Gene” module analysis indicated that ALDOA gene expression was negatively correlated with infiltrating levels of B cells, CD8+ T cells, CD4+ T cells, and macrophages.Conclusion: Our study suggested that upregulated ALDOA was significantly correlated with tumor progression, poor survival, and immune infiltrations in lung adenocarcinoma. These results suggest that ALDOA is a potential prognostic biomarker and therapeutic target in lung adenocarcinoma.