bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utilization of the library recreational function through the Gasibu Library Bandung
Authors: Anwar Rully Khairul , Agustine Merryam 
Published: November 2021

Background of the study: One of the capabilities of the library is to provide pleasant conditions for relaxation that cannot be found at home. This research has the background to find out more about the recreational functions of public libraries through the Gasibu Bandung library which is located around the Gasibu field.
Purpose: The purpose of this study is divided into two parts, namely to determine the recreational function of the library as a means of channeling reading hobbies and to find out the Gasibu library as a tourism developer of Bandung city.
Method: The technique used in this research is a qualitative research technique with a case study method.
Findings: The results of this study indicate that the Gasibu library is an appropriate informative recreation facility to serve as a means of channeling people's reading hobbies and the Gasibu library can add to the tourist attraction of Bandung city because of the uniqueness of the information center in the middle of recreational facilities.
Conclusion: In fulfilling the recreational needs of its users, the Gasibu library is carried out by providing books that are suitable for its purpose. Novels and other literary forms, works of art, travel books, biographies, popular magazines, especially other recreational books. The Gasibu library building is also the main attraction because of its location in the middle of recreational facilities.
ANALISIS PENGARUH KREATIF DAN INOVATIF DI DUNIA BISNIS KEWIRAUSAHAAN DALAM PERSPEKTIF EKONOMI ISLAM
Authors: Novita Mega Angel Virdianasari  
Published: November 2021

In writing this article, it aims to determine the effect of the benefits of creative and innovative ideas in running an entrepreneurial business based in an Islamic economy. The method in writing this article is to use descriptive analysis literature study to analyze the influence of creative and innovative ideas on the entrepreneurial world. The data collection technique is to look for secondary data obtained from sources relevant to the topic of discussion. By taking the title, taking advantage of this idea will have a great opportunity to face existing challenges and have great potential in the face of increasingly fierce business competition today. Because if you don't take advantage of this idea, the business you are running will be unable to compete with similar businesses and consumers will feel uninterested in simple products so that the business we run will experience a decrease in sales levels. Therefore, the existence of this idea will have a considerable influence in the world of economy and business so that consumers do not feel bored to buy and use these products. However, consumers can feel satisfied because they can use products with many benefits that consumers can take advantage.
Dalam penulisan artikel ini bertujuan untuk mengetahui pengaruh manfaat ide kreatif dan inovatif dalam menjalankan bisnis wirausaha yang berbasis dalam ekonomi Islam. Metode dalam penulisan artikel ini ialah dengan menggunakan studi pustaka analisis deskriptif untuk menganalisis pengaruh ide kreatif dan inovatif terhadap dunia usaha wirausaha. Teknik pengumpulan data adalah dengan mencari data sekunder yang diperoleh dari sumber yang relevan dengan topik pembahasan. Dengan mengambil gelar tersebut, karena dengan memanfaatkan ide tersebut akan memiliki peluang yang besar untuk menghadapi tantangan yang ada dan memiliki potensi yang besar dalam menghadapi persaingan bisnis yang semakin ketat saat ini. Karena jika tidak memanfaatkan ide ini maka bisnis yang dijalankan akan kalah bersaing dengan bisnis sejenis dan konsumen akan merasa tidak tertarik pada produk sederhana sehingga bisnis yang kita jalankan akan mengalami penurunan tingkat penjualan. Oleh karena itu, keberadaan ide ini akan memberikan pengaruh yang cukup besar dalam dunia ekonomi dan bisnis agar konsumen tidak merasa bosan untuk membeli dan menggunakan produk tersebut. Namun konsumen dapat merasa puas karena dapat menggunakan produk dengan banyak manfaat yang dapat dimanfaatkan konsumen.
PENGARUH CAPITAL ADEQUACY RATIO, INFLASI, DAN GROSS DOMESTIC PRODUCT TERHADAP RETURN ON ASSETS (STUDI PADA BANK UMUM SYARIAH NON DEVISA DI INDONESIA PERIODE TAHUN 2018-2020)
Authors: Lutfi Indriwati  , Agung Eko Purwana  
Published: November 2021

This research examines the influence of CAR, inflation and GDP on ROA of Non-Foreign Exchange Sharia Commercial Banks in Indonesia. In the research period there were cases in the financial statements where CAR increased but ROA decreased, in addition when inflation decreased ROA also decreased and at the time of GDP rise ROA again decreased. The novelty of this research is a method of regression of panel data that has never been used in CAR, inflation and GDP together. This research is quantitative with a sample number of 4 Non-Foreign Exchange Sharia Commercial Banks. The findings in this study are that CAR, inflation and GDP have no partial effect on ROA. However, CAR, inflation, and GDP simultaneously affect ROA. The next research is expected to take variables other than CAR, inflation, and GDP that theoretically affect roa of Non-Foreign Exchange Sharia Commercial Banks in order to obtain a better roa model of Non-Foreign Exchange Sharia Commercial Banks compared to this study.
Riset ini menguji pengaruh CAR, inflasi dan GDP terhadap ROA Bank Umum Syariah Non Devisa di Indonesia. Pada periode riset ditemui kasus pada laporan keuangan dimana CAR mengalami peningkatan namun ROA mengalami penurunan, selain itu ketika inflasi mengalami penurunan ROA turut mengalami penurunan serta pada saat GDP naik ROA kembali mengalami penurunan. Kebaruan dari riset ini berupa metode regresi data panel yang belum pernah digunakan pada CAR, inflasi dan GDP secara bersama. Riset ini berjenis kuantitatif dengan jumlah sampel 4 Bank Umum Syariah Non Devisa. Temuan pada riset ini adalah CAR, inflasi dan GDP secara parsial tidak berpengaruh pada ROA. Namun, CAR, inflasi, serta GDP secara simultan berpengaruh pada ROA. Riset berikutnya diharapkan dapat mengambil variabel lain selain CAR, inflasi, dan GDP yang secara teori berpengaruh pada ROA Bank Umum Syariah Non Devisa agar diperoleh model ROA Bank Umum Syariah Non Devisa yang lebih baik dibandingkan dengan penelitian ini.
A Novel Clinical Nomogram for Predicting Lymph Node Metastasis in Ovarian Cancer: A SEER Analysis and External Validation in a Tertiary Center
Authors: Zhang Guiping , Ren Wei 
Published: November 2021

Abstract
Introduction

The aim of the study is to investigate the risk factors for developing lymph node metastases (LNM) in cases diagnosed as a presumed early-stage ovarian carcinoma (OC).
Methodology

Information of patients who had been diagnosed as OC in 2018 was obtained from the SEER database. We enrolled 104 OC patients in General Hospital of Northern Theatre Command for external validation. A logistic regression was conducted to determine the independent predictors for LNM, which were used for establishing a nomogram. In order to evaluate the reliability of nomogram, we applied a receiver operating characteristic curve (ROC) analysis, calibration curves and plotted decision curves.
Results

We found that age(≥70, OR=0.544, p=0.022), histology type (Mucinous carcinoma, OR=0.390, p=0.001; Endometrioid carcinoma, OR=7.946, p=0.053; Others, OR=2.400, p=0.040), histology grade (Grade II, OR=2.423, p=0.028; Grade III, OR=1.982, p=0.152; Grade IV, OR=1.594, p=0.063) and preoperative serum CA125 level (positive, OR=2.236, p=0.001) were all significant predictors of LNM. The AUC of the model training cohort, internal validation cohort, and external validation cohort were 0.78, 0.79 and 0.76 respectively. The calibration curves showed that the predicted outcome fitted well to the observed outcome in the training cohort (p=0.825) internal validation cohort (p=0.503), and external validation cohort (p=0.108). The decision curves showed the nomogram had more benefits than the All or None scheme if the threshold probability is >50% and <100% in training cohort and internal validation cohort, >30% and <90% in the external validation cohort.
Conclusion

The multivariate logistic regression showed that age, histology type, histology grade and preoperative serum CA125 level were all significant predictors of LNM. The nomogram established using the above variables had great performance for clinical applying.
Evaluating Positive and Negative Effects of Seven Biogenic Metal-based Nanoparticles on Seed Germination and Seedling of Nano-primed Wheat and Flax Seeds
Authors: Bayat Maryam , Zargar Meisam 
Published: November 2021

Abstract
Seed germination is the first and the most susceptible stage in plant’s growing phases, so could be considered as an index to evaluate the effect of newly developed materials like nanoparticles (NPs), providing useful information for researchers. In our experiments, germination tests have been carried out in Petri plates, containing wet filter paper and nano-primed seeds. We had biosynthesized seven nanoparticles in our previous researches, including calcinated and non-calcinated zinc oxide, zinc, magnesium oxide, silver, copper and iron nanoparticles. The effect of these biogenic nanoparticles and their counterpart metallic salts including zinc acetate, magnesium sulphate, silver nitrate, copper sulphate and iron (III) chloride was studied on two popularly grown plants, wheat and flax, in laboratory condition to obtain preliminary information for future field experiments. Germination percentage, shoot length, root length, seedlings length, root-shoot ratio, seedling vigor index (SVI), shoot length stress tolerance index (SLSI) and root length stress tolerance index (RLSI) were calculated at 2nd and 7th days of the experiment. According to the results, the response of the plants to metal containing nanoparticles and metal salts mainly depend on type of the metal, plant species, concentration of the NP suspension or salt solution, condition of the exposure and the stage of growth.
Self-care Status and Influencing Factors of Patients with Chronic Heart Failure in Community from The Perspective of Health Ecology
Authors: Zhou Bingying , Xu Cuirong , Xu Xiaolu , Chen Yong , Tang Weihong 
Published: November 2021

Abstract
Objective To explore the current situation and influencing factors of self-care of patients with chronic heart failure in community. Methods Patients with chronic heart failure in four community health service centers of a third class hospital in Nanjing were selected as the research object. A questionnaire was formed based on health ecology to understand the current situation and influencing factors of self-care. The data were analyzed by one-way ANOVA and multiple linear regression.Results The self-care status of community patients with chronic heart failure was poor, and they were in the state of "low maintenance, low management and low confidence"; Social support level, anxiety, depression, number of complications, course of disease, education level and income were independent influencing factors of self-care ability of community patients with chronic heart failure (P < 0.05). Conclusion The self-care ability of community patients with chronic heart failure needs to be improved, which is affected by many factors. Personalized evaluation and active intervention should be carried out to improve the self-care ability and quality of life of patients with chronic heart failure.
Artificial Neural Network for analyzing the chaotic time series motion: The case of the Lebanese GDP
Authors: Verne Jean-François 
Published: November 2021

Abstract
In this paper, we propose to analyze the motion of the Lebanese GDP over the period 1950-2019. This macroeconomic aggregate reveals large fluctuations notably during the civil war period (1975-1990). By estimating the Lyapunov exponents with the Artificial Neural Network (ANN) procedure, we show that this series exhibits a strange attractor generated by a chaotic dynamic and we use the embedding procedure to shed in light the bizarre structure of such a series. Thus, the ANN method gives better results regarding prediction than other linear regression models and allows to fit with accuracy the chaotic motion followed by the Lebanese GDP in the phase space.
Molecular Diagnostic of Ochratoxin A with Specific Aptamers in Corn and Groundnut via Fabrication of A Microfluidic Device
Authors: Shahdeo Deepshikha , Khan Azmat Ali , Alanazi Amer M , Huh Yun Suk , Shukla Shruti , Gandhi Sonu 
Published: November 2021

Abstract
Ochratoxin A (OTA) is one of the predominant mycotoxins that contaminate a wide range of food commodities. In the present study, a 36-mer aptamer was used as a molecular recognition element coupled with gold nanoparticles (AuNPs) for colorimetric detection of OTA in a microfluidic paper-based analytical device (µPADs). The µPADs consisted of three zones: control, detection, and sample, interconnected by channels. The biophysical characterizations of aptamer conjugated AuNPs were done by UV-vis spectroscopy (UV-vis), dynamic Light Scattering (DLS), and transmission electron microscopy (TEM). The developed colorimetric assay for OTA showed a limit of detection of 242, 545, and 95.69 ng/mL in water, corn, and groundnut, respectively. The HPLC detection method achieved acceptable coefficient in standard curves (r2 = 0.9995), better detection range, and recovery rates in spiked corn and groundnut samples as 43.61 ± 2.18% to 87.10 ± 1.82% and 42.01 ± 1.31% to 86.03 ± 2.64% after multiple sample extractions and cleanup steps. However, the developed µPADs analytical device had the potent ability to rapidly detect OTA without any extraction pre-requirement, derivatization, and cleanup steps, thus illustrating its feasibility in the animal health sector, agricultural, and food industries.
Downregulation of Lipid Phosphate Phosphatase 3 correlates with Tumor-Infiltrating Immune Cells in Oral Cancer
Authors: Vishwakarma Supriya , Joshi Deepti , Pandey Ritu , Das Saikat , Mukhopadhyay Sramana , Singh Renu , Singhal Ritu , Kapoor Neelkamal , Kumar Ashok 
Published: November 2021

Abstract
Purpose

Sphingosine-1-phosphate (S1P), a potent oncogenic lipid. Intracellular levels of S1P are tightly regulated by eight S1P metabolizing enzymes. S1P is synthesized by phosphorylation of sphingosine which is catalyzed by two sphingosine kinases (SphK1 and SphK2). Five lipid phosphatases (two S1P phosphatases and three lipid phosphate phosphatases) reversibly convert S1P back to sphingosine. S1P is ultimately irreversibly degraded by S1P lyase. The role of sphingosine-1-phosphate (S1P) metabolizing enzymes in oral squamous cell carcinoma (OSCC) has not been fully studied.

Methods

In the current study, we have determined the protein expression of four S1P metabolizing enzymes, namely sphingosine Kinase (SphK) -1, SphK2, S1P phosphatase 1 (SGPP1), and lipid phosphate phosphatase 3 (LPP3) by immunohistochemistry (IHC) and western botting in tumor tissues of 46 OSCC patients and normal oral mucosa (N = 6). Further, we determined the associations of expression of S1P metabolizing enzymes with clinicopathological features of OSCC patients.

Results

SphK2 and LPP3 exhibit low IRS in OSCC tumors. Importantly, expression of SphK2 and LPP3 was downregulated in malignant cells compared to non-malignant mucosa. Further, LPP3 expression negatively correlated with TNM staging of patients (ρ = -0.307, p = 0.043). Importantly, TCGA analysis revealed that LPP3 expression was positively correlated with infiltration of B cells, neutrophils, macrophages, and dendritic cells in the HNSCC tumors.

Conclusion

In conclusion, our data show that expression of SphK2 and LPP3 is decreased in OSCC tumors compared to normal mucosa. Thus, LPP3 could represent a potential prognostic marker and therapeutic target for OSCC.
A Selected Population Study Reveals the Biochemical Mechanism of Intramuscular Fat Deposition in Chicken Meat
Authors: Cui Huanxian , Liu Lu , Liu Xiaojing , Wang Yongli , Luo Na , Tan Xiaodong , Zhu Yuting , Liu Ranran , Zhao Guiping , Wen Jie 
Published: November 2021

Abstract
Background

Increasing intramuscular fat (IMF) is an important strategy to improve meat quality, but the regulation mechanism of IMF deposition needs to be systematically clarified.
Results

A total of 520 chickens from a selected line with improved IMF content and a control line were used to investigate the biochemical mechanism of IMF deposition in chickens. The results showed that the increased IMF would improve the flavor and tenderness quality of chicken meat. IMF content was mainly determined both by measuring triglyceride (TG) and phospholipid (PLIP) in muscle tissue, but only TG content was found to be decisive for IMF deposition. Furthermore, the increase in major fatty acid (FA) components in IMF is mainly derived from TGs (including C16:0, C16:1, C18:1n9c, and C18:2n6c, etc.), and the inhibition of certain very-long-chain FAs would help to IMF/TG deposition.
Conclusions

Our study elucidated the underlying biochemical mechanism of IMF deposition in chicken: Prevalent accumulation of long-chain FAs and inhibitions of medium-chain FAs and very long chain-FA would synergistically result in the increase of TGs with the FA biosynthesis and cellular uptake ways. Our findings will guide the production of high-quality chicken meat.
Metabolomics Profiling of Brassinolide and Abscisic Acid In Response to High Temperature Stress
Authors: Lv Jinhua , Dong Tianyu , Zhang Yanping , Ku Yu , Zheng Ting , Jia Haifeng , Fang Jinggui 
Published: November 2021

Abstract
To determine the effect of abscisic acid (ABA), brassinolide (BR) and ABA+BR on grape quality under high temperature stress (HTS), various metabolites were analyzed. Compared with the control (CK), DL-tryptophan, D-raffinose, geniposidic acid, dodecanedioic acid and polyphenols were found to be higher after ABA treatment. After BR treatment, amino acids and poricoic acid B were higher than in CK. And carbohydrates and amino acids were upregulated after ABA+BR treatment. BR and ABA+BR treatment also induced higher endogenous ABA and epibrassinolide (EBR) contents. In addition, treated grape had higher soluble solid concentrations (SSC) and soluble sugar content, and delayed the degradation of middle lamella and microfibrils. Antioxidant and heat shock related genes were examined, which significantly increased in treated grape. The finding of this study suggested that ABA, BR and ABA+BR are very useful for alleviating high temperature damage by increasing the accumulation of osmotic adjustment substances, and endogenous hormones content.
Investigating EFL Learners’ Perceptions Towards the Difficulties in Oral Presentation at Kandahar University
Authors: Tareen Hashmatullah , Faizi Farishta 
Published: November 2021

Abstract
This research paper examines the difficulties of oral presentation, strategies coping with difficulties used in oral presentations and the perceived role of lecturer in improving EFL learners’ oral presentation skills. The study used quantitative approach in which a survey questionnaire comprising 34 items based on four likert scales was distributed to EFL learners in a public university. The data was collected from 150 learners from two English Departments through random sampling which 109 were male and 41 were female learners. The data was analyzed and interpreted in terms of mean and standard deviation through SPSS software (22) version. The results of the study revealed that learners had a problem with oral fluency, accuracy and pronunciation during oral presentation, feel frightened when a lot of people are watching them, afraid of being assessed by their classmates in front of the class, having low self-confidence. The results also revealed some strategies coping with difficulties used in oral presentation such as, learners have to prepare themselves properly before an oral presentation, they have to build self-confidence for presentation to present very well and they have to concentrate more on phonetics and phonology of language. Furthermore, considering a crucial role of lecturer in improving oral presentation skills, the following factors such as lecturer has to design a specific course in teaching oral presentation skills for EFL learners, lecturer has to show learners videos of good speakers for enhancing their presentation skill and lecturer has to give learners freedom to choose their own topic that lowers their anxiety were discovered for more consideration.
How Does HbA1c Predict Mortality and Readmission in Patients with Heart Failure? A Protocol for Systematic Review and Meta-analysis
Authors: Xu Junpeng , Zeng Ruixiang , Mai Xiaoyi , Pan Wenjun , Zhang Yuzhuo , Zhang Minzhou 
Published: November 2021

Abstract
BackgroundAccumulating evidence suggests that HbA1c levels, a common clinical indicator of chronic glucose metabolism over the preceding 2-3 months, are independent risk factor for cardiovascular disease, including heart failure. The aim of this protocol is to conduct a systematic review and meta-analysis to assess the possible predictive value of HbA1c on mortality and readmission in patients with heart failure.MethodsA systematic and comprehensive search will be performed using PubMed, Embase, Central and other databases before August 2021 to identify relevant trials. All-cause mortality is the pre-specified primary endpoint. Cardiovascular death and heart failure readmission are secondary interested endpoints. We will only include prospective and retrospective cohort trials and place no restrictions on the language, race, region and publication period. The Newcastle-Ottawa Scale will be used to assess the quality of each trial included. If there are sufficient trials, we will conduct meta-analysis with pooled relative risks and corresponding 95% confidence interval to evaluate the possible predictive value of HbA1c on mortality and readmission. Otherwise, we will undertake a narrative synthesis. Heterogeneity and publication bias will be assessed. If heterogeneity is significant among included trails, a sensitivity analysis or subgroup analysis will be used to explore the source of heterogeneity, such as diverse types of heart failure or patients with diabetes and non-diabetes. Also, we will conduct meta-regression to examine the time-effect and treatment-effect modifiers on all-cause mortality compared between different quantile of HbA1c levels. Finally, a restricted cubic spline model may be used to explore the dose-response relationship between HbA1c and adverse outcomes.DiscussionThis planned analysis is anticipated to identify the predictive value of HbA1c on mortality and readmission in patients with heart failure. Improved understanding of different HbA1c levels and their specific effect on diverse types of heart failure or patients with diabetes and non-diabetes is expected to be figured out. Also, a dose-response relationship or optimal range of HbA1c will be determined to instruct clinicians and patients.PROSPERO registration detailsCRD42021276067