bluuebunny/crossref_metadata_2025_split huggingface dataset:
International registry of dermatological manifestations secondary to COVID‐19 infection in 347 Hispanic patients from 25 countries
Authors: Ocampo‐Candiani Jorge , Ramos‐Cavazos Cesar Jair , Arellano‐Mendoza Maria Ivonne , Arenas‐Guzmán Roberto , Beirana‐Palencia Angélica , Salmon‐Demongin Alfredo , Welsh‐Hernández Esperanza , Cabo Horacio A. , Gómez‐Flores Minerva , Dominguez‐Cherit Judith , Criado Paulo Ricardo , Castro‐López Helena , Alfaro‐Sánchez Abraham Benjamin , García‐Vargas Alejandro , Cohen‐Sabban Emilia N. , del Solar Manuel , Fich Félix , Galimberti Gastón , Gatti Carlos Fernando , López‐Estebaranz José Luis , Lupi Omar , Olmos‐Pérez Miguel , Pérez‐Alfonzo Ricardo 
Published: May 2021

AbstractBackgroundThe infection by coronavirus disease 2019 (COVID‐19) has been associated with multiple cutaneous manifestations, although characterization of them in Hispanic patients with darker skin phototypes is lacking. The objective of this study is to characterize the clinical dermatological manifestations associated with COVID‐19 infection in cases with few or without general symptoms in patients from Latin America.MethodsCross‐sectional study using a questionnaire that was made for health professionals (physicians with a specialty in dermatology) to investigate dermatological lesions associated with COVID‐19 infection in patients from 25 countries of Latin America. The survey was active from June 9 to July 30, 2020.ResultsIn this study, information was collected from a total of 347 patients. We found a female gender predominance: 179/347 (51.6%). The mean age at presentation was 40.87 years. The most frequent dermatological manifestations were maculopapular rash and urticarial lesions, followed by papulovesicular lesions, vesicular lesions, chilblain‐like lesions, papular lesions, ecchymosis, petechial purpura, pityriasis rosea‐like lesions, pruritus, palmoplantar dysesthesias, transient livedo, acral necrosis, palpable purpura, livedo racemosa, and retiform purpura. As far as we know, there are no previous reports of pruritus and palmoplantar dysesthesias.ConclusionsThis registry emphasizes skin manifestations as an important criterion for establishing the diagnosis of COVID‐19 infection in Latin American countries. This information will be useful for the early identification of suspected cases by health professionals (dermatologists and nondermatologists) and will allow contact tracing to mitigate the impact on health systems at different levels.
Application of whey of Mozzarella di Bufala Campana fermented by lactic acid bacteria as a bread biopreservative agent
Authors: Luz Carlos , Quiles Juan M. , Romano Raffaele , Blaiotta Giuseppe , Rodríguez Lorena , Meca Giuseppe 
Published: May 2021

SummaryA total of nine isolated lactic acid bacteria (LAB) from tomato and sourdough with antifungal activity were employed to revaluate the whey of Mozzarella di Bufala through the fermentation process for 72 h at 37 °C. Then, the fermented whey (BWF) was characterised and used as biopreservative in bread formulation. L. plantarum TR7 and L. plantarum TR2 strains showed average lactic acid concentration in BWF of 13.8 g L−1. Also, the bread volatile organic compounds (VOC) analysis showed an increase in hexanal, benzeneacetaldehyde, benzaldehyde and pyrazine tetramethyl when using BWF as ingredient. Moreover, the DPPH‐inhibitory activity of bread with BWF extract also reflected a 33% rise in comparison with control bread. The application of BWF as a biopreservation agent in bread showed an increase in shelf life compared with bread with 0.3% calcium propionate and bread control for 2 and 15 days, respectively. BWF can be used as an interesting biopreservation strategy of bread.
Rule‐based versus feedback‐based coaching for situational judgment tests
Authors: Zhang Charlene , Sackett Paul R. , Naemi Bobby D. 
Published: May 2021

AbstractThe use of situational judgment tests (SJTs) in high‐stakes selection contexts has led to the emergence of commercial coaching programs aimed at increasing individuals’ performance. The present study uses a pre–post experimental design to investigate coaching effects on an SJT’s mean score and relationships with external variables. General strategies with which to guide how respondents answer SJT questions were developed for rule‐based coaching. Item‐level feedback was provided for feedback‐based coaching. Results suggest that (a) both rule‐based and feedback‐based coaching are similarly effective at increasing mean SJT scores, (b) coaching does not detract from the SJT’s ability to correlate with other variables, and (c) knowledge of ineffective behaviors are more coachable than knowledge of effective behaviors.
Psychometric validation of the Portuguese version of the Measure of Anxiety in Selection Interviews
Authors: Santos Anabela Caetano , Arriaga Patrícia , Simões Celeste 
Published: May 2021

AbstractFeeling anxiety in a job interview is common. It is important to have a valid, reliable, and culturally adapted measure, enabling cross‐cultural comparisons. Our main goal was to examine the psychometric properties of the Measure of Anxiety in Selection Interviews (MASI) in a Portuguese sample, since no similar measure is available in the Portuguese language. The MASI was developed to capture five dimensions of anxiety: Communication, appearance, social, performance, and behavior. We tested 436 participants (337 women; aged 18–61 years old) with and without prior job interview experience. Confirmatory factor analysis indicated an adequate fit for the five‐factor solution. Good internal and test–retest reliability (two weeks between assessments) was observed. The MASI‐P positively correlated with social anxiety/fear, but negatively correlated with age, number of previous job interviews, and perceived performance on the last job interview. Overall, the use of MASI‐P can be advantageous in job interview training, research, and employment processes.
Prevention and management of infectious complications in prostate biopsy: A review
Authors: Shigemura Katsumi , Fujisawa Masato 
Published: May 2021

AbstractProstate biopsies are common procedures for urologists, performed in order to detect and diagnose prostate cancer. Procedures continue to evolve, for instance, recently there has been an increase in the use of the transperineal approach, and the emergence of antibiotic‐resistant bacteria has become a challenge. This review examines the recent prostate biopsy literature as well as the guidelines of three urological associations. We review the recent literature, including our own recent studies, and the Japanese Urological Association, European Association of Urology and American Urological Association guidelines, and summarize the current recommendations regarding the prevention of infectious complications that can occur after prostate biopsy, including the use of antimicrobial agents, and the management and treatment of such complications. Current recommendations include single‐dose or 1‐day use of oral quinolones for infection control, along with consideration of high‐risk patients with diabetes, steroid use, large prostates, or high residual urine volume for instance. Targeted therapies based on the results of rectal swabs carried out prior to transrectal prostate biopsy, which can provide better inhibitory data with regard to post‐prostate biopsy infectious complications, can also be considered. In conclusion, oral quinolones for low‐risk patients and targeted therapies for high‐risk patients are recommended when using a transrectal approach to prostate biopsy, and oral quinolones are recommended when using a transperineal approach. Further randomized controlled trials are necessary to draw more definitive conclusions.
Decreased urothelial cytoskeleton and cell proliferation protein expression suggest interstitial cystitis/bladder pain syndrome patients with Hunner’s lesion and grade 3 glomerulation might be different from other types of patients
Authors: Jhang Jia‐Fong , Jiang Yuan‐Hong , Hsu Yung‐Hsiang , Ho Han‐Chen , Kuo Hann‐Chorng 
Published: May 2021

ObjectivesTo explore the expression of cytoskeletal and cell proliferation proteins in urothelial cells of patients diagnosed with various clinical subtypes of interstitial cystitis/bladder pain syndrome.MethodsBiopsy specimens from 85 interstitial cystitis/bladder pain syndrome patients were classified according to findings on cystoscopy. Cytokeratins and cell proliferation proteins detected in the specimens were evaluated with immunofluorescence staining and quantified with western blotting. A total of 22 patients diagnosed with pure stress urinary incontinence were enrolled as controls.ResultsInterstitial cystitis/bladder pain syndrome patients with Hunner’s lesion and with grade 3 glomerulation hemorrhage had smaller bladder capacities than the other interstitial cystitis/bladder pain syndrome patients without Hunner’s lesion. Diminished expression of CK14, CK20, cell proliferation protein tumor protein 63, sonic hedgehog, and fibroblast growth factor receptors 3 and 4, and increased expression of CK5 and BCL2‐associated X protein were observed in biopsy specimens from patients with Hunner’s lesion compared with those from patients without Hunner’s lesion and controls. In the patients with grade 3 glomerulation hemorrhage, lower expression levels of urothelial CK20, tumor protein 63 and fibroblast growth factor receptor 4, and lower expression of CK5 and BCL2‐associated X protein were detected compared with other types of NHIC.ConclusionA diminished expression of proliferation proteins tumor protein 63 and the mature urothelium marker CK20, and increased expression of the immature marker CK5 in specimens from both Hunner’s lesion and grade 3 glomerulation hemorrhage patients can be observed. The urothelium of patients with interstitial cystitis/bladder pain syndrome might be in a state of persistent or chronic injury that could relate to the limited expression of cell proliferation proteins.
Spatial control of gene expression in flies using bacterially derived binary transactivation systems
Authors: Gamez S. , Vesga L. C. , Mendez‐Sanchez S. C. , Akbari O. S. 
Published: May 2021

AbstractControlling gene expression is an instrumental tool for biotechnology, as it enables the dissection of gene function, affording precise spatial–temporal resolution. To generate this control, binary transactivational systems have been used employing a modular activator consisting of a DNA binding domain(s) fused to activation domain(s). For fly genetics, many binary transactivational systems have been exploited in vivo; however, as the study of complex problems often requires multiple systems that can be used in parallel, there is a need to identify additional bipartite genetic systems. To expand this molecular genetic toolbox, we tested multiple bacterially derived binary transactivational systems in Drosophila melanogaster including the p‐CymR operon from Pseudomonas putida, PipR operon from Streptomyces coelicolor, TtgR operon from Pseudomonas putida and the VanR operon from Caulobacter crescentus. Our work provides the first characterization of these systems in an animal model in vivo. For each system, we demonstrate robust tissue‐specific spatial transactivation of reporter gene expression, enabling future studies to exploit these transactivational systems for molecular genetic studies.
Migrant trailing spouses: Career adaptability and occupational downshifting
Authors: Venugopal Vidhula , Huq Afreen 
Published: May 2021

AbstractThis study examines career adaptability of trailing spouses whose comparative advantage most strikingly illustrates the erosion over time of career agency for migrant women, or what is known as “occupational downshifting.” Problematising occupational downshifting as a major obstacle to social integration of trailing spouses, we explore how cultural tensions play out vocationally, and the career choices available to trailing spouses become so diminished over time that their agency can be considered “bounded.” Using a life story approach, our study provides evidence of the lived experiences of constrained agency and paradox of 12 early childhood educators in Australia. Our evidence demonstrates that the choice of moving for the family not only creates occupational precarity, but a more grievous occupational downshifting. We consider strategies like vocational facilitation to address the needs of trailing spouses as individuals, and as such facilitate migrant integration and neutralise the forces leading to occupational downshifting.
Interdependencies between Toll‐like receptors in Leishmania infection
Authors: Shukla Divanshu , Patidar Ashok , Sarma Uddipan , Chauhan Prashant , Pandey Surya Prakash , Chandel Himanshu Singh , Bodhale Neelam , Ghosh Soumya Kanti , Guzman Carlos Alberto , Ebensen Thomas , Silvestre Ricardo , Sarkar Arup , Saha Bhaskar , Bhattacharjee Surajit 
Published: May 2021

AbstractMultiple pathogen‐associated molecular patterns (PAMPs) on a pathogen's surface imply their simultaneous recognition by the host cell membrane‐located multiple PAMP‐specific Toll‐like receptors (TLRs). The TLRs on endosomes recognize internalized pathogen‐derived nucleic acids and trigger anti‐pathogen immune responses aimed at eliminating the intracellular pathogen. Whether the TLRs influence each other's expression and effector responses—termed TLR interdependency—remains unknown. Herein, we first probed the existence of TLR interdependencies and next determined how targeting TLR interdependencies might determine the outcome of Leishmania infection. We observed that TLRs selectively altered expression of their own and of other TLRs revealing novel TLR interdependencies. Leishmania major—an intra‐macrophage parasite inflicting the disease cutaneous leishmaniasis in 88 countries—altered this TLR interdependency unfolding a unique immune evasion mechanism. We targeted this TLR interdependency by selective silencing of rationally chosen TLRs and by stimulation with selective TLR ligands working out a novel phase‐specific treatment regimen. Targeting the TLR interdependency elicited a host‐protective anti‐leishmanial immune response and reduced parasite burden. To test whether this observation could be used as a scientific rationale for treating a potentially fatal L. donovani infection, which causes visceral leishmaniasis, we targeted the inter‐TLR dependency adopting the same treatment regimen. We observed reduced splenic Leishman–Donovan units accompanied by host‐protective immune response in susceptible BALB/c mice. The TLR interdependency optimizes TLR‐induced immune response by a novel immunoregulatory framework and scientifically rationalizes targeting TLRs in tandem and in sequence for redirecting immune responses against an intracellular pathogen.
The effect of ankyloglossia and tongue‐tie division on speech articulation: A systematic review
Authors: Wang Jiahe , Yang Xiaoyu , Hao Siyuan , Wang Yan 
Published: May 2021

AbstractAimAnkyloglossia is a common congenital malformation characterized by a short, thick, or tight tongue frenulum, and its effect on speech articulation remains controversial. This study aimed to evaluate (a) the association between ankyloglossia and speech disorders, and (b) the effectiveness of surgical interventions on the articulation of patients with ankyloglossia.Material and MethodsA comprehensive search of PubMed was conducted. Randomized control trials (RCTs), cohort studies, case‐control studies, and case series with more than five cases were included.ResultOf the 16 included studies, except for one cross‐sectional study, all studies were small in sample size. The evidence quality was generally low, with an average of 3.88 in a 7‐point system. Three studies investigated the occurrence of speech disorders in the ankyloglossia population and obtained different results. Fifteen studies assessed the effectiveness of surgery, among which eight self‐control studies observed significant postoperative improvement, whereas three of four cohort studies with untreated controls reported no significant differences. Three RCTs compared surgical techniques and one pointed out the advantage of frenuloplasty over frenulotomy.ConclusionThere was no clear connection between ankyloglossia and speech disorders. More widely accepted uniform grading systems and well‐designed clinical studies are needed.
Discovery of new broadband yellow‐emitting nitridoalumosilicate phosphor and its pc‐WLED application
Authors: Ye Shanshan , Zhao Quan , Geng Wanying , Zhang Weibin , Cai Zhihui , Wu Peng , Ding Jianyan , Wu Quansheng 
Published: May 2021

AbstractDeveloping a yellow phosphor with broadband emission covering more red‐light areas is an effective approach to achieve high‐quality solid‐state lighting. In this study, a novel yellow‐emitting nitride phosphor, Ca5Si2Al2N8:Ce3+, was successfully prepared at atmospheric pressure and lower temperatures (1300°C), and its structure‐property relation was revealed using crystal refinement, photoluminescence (PL) spectra, time‐resolved PL spectra, and density‐functional theory calculations. The results demonstrate that Ca atoms occupy three different crystallographic sites in the lattice, which are substituted by Ce3+ to form multiple luminescence centers. Thus, Ca5Si2Al2N8:Ce3+ emits strong yellow light with a maximum peak at 585 nm and a wide emission band. Compared with YAG:Ce3+, Ca5Si2Al2N8:Ce3+ has a wider emission band with a FWHM of 150 nm, which can effectively cover the green and red areas. Moreover, the sample can be fully excited by a blue LED chip due to its broad excitation band. Notably, the Ca5Si2Al2N8's tight crystal structure composed of edge‐sharing AlN4 and SiN4 tetrahedra pairs guarantee its thermochemical stability and quantum efficiency. Furthermore, Ca5Si2Al2N8:Ce3+ exhibits better thermal stability than YAG:Ce3+. The results indicate that Ca5Si2Al2N8:Ce3+ is a promising yellow phosphor for WLEDs.
Direct ink writing of hierarchical porous ultra‐high temperature ceramics (ZrB2)
Authors: Sesso Mitchell L. , Slater Sonya , Thornton John , Franks George V. 
Published: May 2021

AbstractAn approach to producing hierarchical multi‐scale porous ultra‐high temperature ceramics (zirconium diboride, ZrB2) using 3D printing has been developed. Porous ceramic filaments can be 3D printed via Direct Ink Writing (DIW) (paste extrusion). Millimeter scale porosity is created by the 3D printed scaffold filaments. We introduce 20‐micron‐scale porosity into the scaffold filaments with the addition of oil to produce capillary suspension paste inks. Micron‐scale porosity is also developed by partial sintering of the ceramic. The rheological (flow) properties of the capillary suspension paste inks suitable for printing by extrusion through the needle of the 3D printer have been characterized. The samples are strengthened by partial sintering at high temperatures. Complex‐shaped components can be printed and sintered into crack‐free components, but distortion during drying and sintering lead to poor shape and tolerance control. X‐ray tomography is used to characterize the internal structure of the printed components. Printed test bars measured in 4‐point bend testing exhibit high strength to density ratio. Such materials potentially have applications as insulation near very high‐temperature surfaces in aerospace applications.
Plasma bubbling effect on essential oil yield, extraction efficiency, and flavor compound of Cuminum cyminum L. seeds
Authors: Sharanyakanth Paatre Shashikanthalu , Lokeswari Ramireddy , Mahendran Radhakrishnan 
Published: May 2021

AbstractPlasma bubbling at solid–liquid mixture is a non‐thermal technology for spice processing to retain its flavors and fragrances. Cumin is a regularly consumed spice with significant medicinal properties and has 2–5% essential oil that imparts the characteristic aroma to the seeds. Plasma bubbling influence at a different voltage (175, 180, and 185 V), exposure time (30, 60, and 90 min), and particle size (whole and 0.5 mm) on the essential oil yield and its subsequent effect on flavor compounds were estimated. Increase of voltage to 185 V and bubbling time to 90 min, cumin essential oil yield and extraction efficiency raised from 2.42 to 3.22% and 55.89 to 74.36% for 0.5 mm size, 3.22 to 4% and 74.36 to 92.37% for whole seeds respectively compared to control. Gas chromatography–mass spectrometry analysis showed 21.27 and 31.48% enhancement in cuminaldehyde content after plasma bubbling compared to control of whole and 0.5 mm seeds, respectively.Practical applicationsAn approach to optimize non‐thermal plasma bubbling process parameters for improving Cuminum cyminum L. essential oil extraction by retaining its flavor compound (Cuminaldehyde) was performed in the present study. Plasma bubbling assisted hydrodistillation method is easy, cost‐effective, and also retains flavor compound in essential oil. The data obtained are valuable to scale up a batch scale plasma bubbling process extraction of cumin essential oil to a large or pilot‐scale system since the results showed a rise in essential oil extraction yield and improvement in cuminaldehyde content.
Electrically assisted ionic gelling encapsulation of enzymatically extracted zinc‐chlorophyll derivatives from stinging nettle (Urtica urens L.)
Authors: Tekin İdil , Ersus Seda 
Published: May 2021

AbstractThis study evaluates the effect of four different encapsulation techniques. Zn‐chlorophyll derivatives obtained by enzymatic extraction with 26.80% yield compared to nonenzymatic extraction from stinging nettle were encapsulated with (i) ionic gelling, (ii) ionic gelling + chitosan coating, (iii) electrically assisted ionic gelling (iv) electrically assisted ionic gelling + chitosan coating methods. The decrease in total chlorophyll content at the end of the 8 weeks storage in the capsules according to the initial amount was found to be 17.32, 44.97, 4.18 and 26.52%, respectively. Depending on the total chlorophyll content, the decrease in a* value in the capsules according to the initial amount was found to be 30.00, 68.63, 8.16 and 53.04%, respectively. The capsules prepared by the electrical method provided the highest protection of chlorophyll during storage. Chitosan application as a second layer to capsules resulted in an increase in chlorophyll decay in both ionic gelling and electrically assisted ionic gelling methods (p < 0.05). It has been determined that the application of chitosan in chlorophyll encapsulation is not appropriate due to the poor color and malodor effect.Practical applicationsNatural colorants are food additives that are widely used to increase the acceptance of products in the food industry. Nowadays, the demand of consumers for natural products has increased the studies on this subject and the search for solutions to problems. The most important problem of natural colorants is their low stability. The development of natural colorants with high stability requires different techniques such as encapsulation or innovations in the molecular structure. With the applied techniques, the stability of natural products can be increased as well as innovative forms of the products obtained can find market share in the industry.