bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early postoperative seizures in liver and kidney recipients
Authors: Tsirulnikova O. M. , Syrkina A. V. , Miloserdov I. A. , Pashkova I. E. , Oleshkevich S. Yu. , Komarova I. B. 
Published: July 2021

Background. Transplantation is presently the only treatment for end-stage liver and kidney failure. Up to 42% of liver transplant recipients and up to 30% of kidney transplant recipients have neurological complications from the transplantation. Acute symptomatic seizures (ACS) occupy an important place in the structure of early postoperative neurological complications. Verification of the causes of seizures and management of the risk of relapse is presently a critical task.Objective: to review recent advances in ACS assessment, prevalence, and treatment approaches in liver and kidney transplant recipients.Materials and methods. The causes of ACS after liver and kidney transplant are diverse. Nonspecific causes of seizures such as dysmetabolic and volemic changes associated with transplantation are widely known. There are also specific syndromes associated with seizures in liver and kidney recipients, such as posterior reversible leukoencephalopathy syndrome, neurotoxicity of calcineurin inhibitors, hyponatremia in the final stage of liver failure, hypocalcemia in kidney recipients, etc. Diagnosis is made based on general rules, and treatment depends on the identified causes of seizures. Management of acute symptomatic seizures involves prescribing anticonvulsants according to the risk of seizure recurrence; immunosuppression is converted when neurotoxicity is identified. Results. The diagnostic algorithm, and often the treatment strategies, in ACS cases in liver and kidney recipients, are not clearly defined.Conclusion. Due to the multiple causes of ACS, there are differences in treatment tactics. Further accumulation and generalization of ACS outcome data will help in creating a convenient algorithm for rapid identification of the cause and the most effective treatment tactics.
Kidney transplantation in Kazakhstan: the burden of organ shortage
Authors: Abdugafarov S. A. , Assykbayev M. N. , Saparbay D. J. 
Published: July 2021

Kidney transplantation has been the best replacement therapy for end-stage kidney disease for over 60 years. The Republican Coordination Center for Transplantation reports that as of January 29, 2020, there were 2675 people on the kidney transplant waiting list in the Republic of Kazakhstan. The issue of deceased donation in Kazakhstan is problematic for various reasons. Over the past couple of years, the already low rates of deceased donors have fallen by more than 2 times.Objective: to objectively assess the effectiveness of deceased-donor kidney transplant in order to indicate the need for development of cadaveric donation and reduce the number of patients in the transplant waitlist.Materials and methods. Fifty-two kidney transplants from a deceased donor were performed at the National Research Oncology Center (NROC) from 2010 to 2020. The age group of recipients ranged from 20 to 75 years old. In most cases, end-stage chronic renal failure resulted in chronic glomerulonephritis (76%), pyelonephritis (1.9%), polycystic kidney disease (9.6%) and diabetic nephropathy (11.5%).Results. The 1-year and 5-year survival rates were 96% and 86%, respectively. There was delayed graft function in 13 of cases. In one case (1.92%), there was intraoperative hyperacute rejection of the kidney transplant that could not be treated with high doses of glucocorticosteroids; the kidney graft was removed. Two patients (3.8%) in the early postoperative period, on days 2 and 7 after surgery, developed a clinic of acute renal transplant rejection; after the rejection crisis was stopped by drug therapy, graft function was restored. One patient (1.92%) died as a result of bilateral pneumonia, which led to sepsis and death.Conclusion. Graft and recipient survival rates after deceased-donor kidney are comparable to those after living-donor kidney transplantation. The solution to the problems of increasing the number of deceased organ transplants should not rest entirely on the shoulders of transplant doctors; this task must also be addressed at the government level with constant propaganda to explain to the citizens the need for a deceased organ donation program.
Numerical and experimental justification of transcatheter aortic valve prosthesis design
Authors: Ovcharenko E. A. , Klyshnikov K. U. , Shilov A. A. , Scheglova N. A. , Glushkova T. V. , Nushtaev D. V. , Barbarash L. S. 
Published: July 2021

Objective: to justify the design of a self-expanding transcatheter aortic valve prosthesis based on a biomaterial stabilized with ethylene glycol diglycidyl ether using numerical simulation and a series of field experiments with working prototypes to determine the consistency of the proposed design solutions.Material and methods. Numerical computer models of a developed aortic valve prosthesis intended for transcatheter implantation, as well as prototypes of the most promising concepts for a series of field tests, were used in the work. Computer 3D models were subjected to numerical analysis in the Abaqus/CAE environment (Dassault Systemes, France) based on the finite element method with iterative design optimization and repeated numerical experiments. Physical prototypes of the transcatheter prosthesis were subjected to a series of mechanical tests for axial and radial compression, as well as tests on a Vivitro hydrodynamic stand (Vivitro Labs, Canada) under simulated normal flow. All studies were carried out in a comparative aspect with a similar transcatheter aortic valve prosthesis (control), the CoreValve™ bioprosthesis (Medtronic, Inc., USA).Results. Computer simulation demonstrates the stress-strain state values that do not significantly exceed the critical levels (628 and 756 MPa versus the threshold value 1080 MPa) for two basic concepts of support frames. The fatigue strength based on the calculation of the mean and alternating stresses corresponding to normo- and hypertensive states based on the Goodman diagrams, did not reveal any evidence that the threshold values (destruction area after 200 million cycles) were exceeded. The hydrodynamic characteristics of working prototypes made on the basis of computer models correspond to the testing data of CoreValve™ clinical bioprosthesis: the effective orifice area was 1.97 cm2, the mean transprosthetic gradient was 8.9 mm Hg, the regurgitant volume was 2.2–4.1 mL per cycle depending on the prototype model.Conclusion. Generally, experiments carried out showed the consistency of the concepts, including from the point of view of implementation of the leaflet apparatus based on xenogeneic tissues treated with ethylene glycol diglycidyl ether.
IMPRESSÕES DOS ALUNOS DE UM CURSO DE BACHARELADO EM SISTEMAS DE INFORMAÇÃO ACERCA DO ENSINO REMOTO DURANTE A PANDEMIA DE COVID-19
Authors: Silveira Sidnei Renato , Delepiane de Vit Antônio Rodrigo , Bertolini Cristiano , Bernardino da Cunha Guilherme 
Published: July 2021

Este artigo apresenta um relato de experiências, compreendendo as impressões dos alunos do Curso de Bacharelado em Sistemas de Informação da Universidade Federal de Santa Maria (UFSM) – Campus Frederico Westphalen/RS, acerca das vantagens e desvantagens do Regime Especial Domiciliar de Estudos (REDE), bem como as ferramentas e estratégias adotadas pelos docentes para atender ao referido regime de estudos. A instituição adotou o REDE em março de 2020, devido ao isolamento social provocado pela pandemia de covid-19. Nesse contexto, as atividades relacionadas aos processos de ensino e de aprendizagem precisaram ser repensadas, aplicando-se Tecnologias Digitais da Informação e da Comunicação (TDICs), Ambientes Virtuais de Aprendizagem (AVAs) e ferramentas para o desenvolvimento de videoaulas. O relato apresenta as impressões de um grupo de alunos que cursaram a disciplina de Computadores e Sociedade, destacando as vantagens e desvantagens que perceberam em relação ao REDE. Os resultados apontam que as principais vantagens envolvem a flexibilidade de horários e a possibilidade de estudar em qualquer lugar. As desvantagens mais destacadas compreendem a necessidade dos alunos de adquirirem maior autonomia e responsabilidade – o que são, também, vantagens – e a falta de contato presencial com professores e colegas, o que diminui a interação.
Weight and histopathological changes in pancreas in alleged suicide cases
Authors: Singh Amandeep , Singh Preet Inder , Kumar Ajay , Harish Dasari 
Published: July 2021

Pancreas will respond differently to stress situations, which results in histopathological changes in the gland. Glucagon and insulin are both secreted by pancreas, the former by alpha cells and latter by beta cells. Insulin may decrease during stress. These endocrine secretions enter the portal vein so that liver is exposed to high concentration of these hormones. This along with increase in its antagonistic hormones can contribute to the stressed induced hyperglycaemia. The aim is to find and compare the weight and histopathological changes of Pancreas in suicide and non suicide deaths. The pancreas were dissected during the autopsy from the cases with known history of death due to alleged suicide with clear history of non administration of steroids and was declared brought dead at GMCH, Chandigarh. The removed glands were preserved and fixed with 10% formalin for more than 2 weeks. After the period of fixation, grossing and section of gland was done, and slides of each subject was prepared and studied.In suicide group maximum weight is 78.2 grams and minimum is 67.3 grams. In non suicide maximum weight is 78.2 grams and minimum is 65.5 grams. The mean weight of the pancreas in the suicidal group was 71.27 grams and the standard deviation was 2.18 grams, whereas the mean weight of the pancreas in the non- suicidal group was 70.87 grams and the standard deviation was 2.63 grams. The P value comes out to be 0.41. Of the total 100 cases, only three (3%) revealed significant pathological findings and the rest 97 (97%) were histologically normal. In the study group there was one case each of pancreatic abscess, and necrotising pancreatitis. Pancreatitis abscess was diagnosed when the histology revealed focus of necrosis of the pancreatic parenchyma with dense neutrophilic infiltration. Necrotising pancreatitis showed extensive necrotising inflammation of the pancreatic parenchyma. In the control group there was only 1 case (2%), of chronic pancreatitis. Chronic pancreatitis was labelled when fibrosis of the pancreatic parenchyma with mild lymphomononuclear cell infiltration. There was no significant difference between the weight of the pancreas in the suicidal and the non-suicidal group. Pathological findings were twice as common in the suicidal group as compared to the non-suicidal group.
Estimation of stature from outstretched arm span and measurement of component/s of upper limb in the natives of Gujarat
Authors: Lalhminghlua R , Saiyed Mohammed Ziyauddin G , Nayak Manjit , Jani C B 
Published: July 2021

The outstretched arm span and measurement of components of the upper limb are a reliable predictors of stature when fragmentary remains of the human body are found. However, this relationship can be affected by age, sex, diet, racial and geographical differences, etc. Hence, a regional database is necessary to be more accurate. This cross-sectional, prospective analytical study included 200 students pursuing MBBS (Male = 100, Female = 100), natives of Gujarat, aged between 18 - 24 years with normal developmental history. Rich bells stature meter, Anthropometric metal rods (scaled), and Vernier caliper were used for taking measurements. SPSS software version 26 was used for statistical analysis. The findings showed a positive correlation between stature and the outstretched arm span as well as stature and various components of the upper limb. Except for the correlation between stature and the length of the shoulder to mid suprasternal notch in males, all of the results were statistically significant (p &#60; 0.05). Regression equations were derived and verified.Outstretched arm span is the most reliable indicator of stature whereas the length of the shoulder to mid suprasternal notch is the least reliable indicator of stature in both sexes in the natives of Gujarat. This study can be used as a reference in the future for medico-legal purposes.
To study histopathological features, GFAP staining and Ki 67/ MIB-1 labelling index in diagnoses and histological grading of gliomas
Authors: Verma Kavita , Negi Satya Raj , Garhwal Sanjay 
Published: July 2021

: A group of tumors that develops in the brain and spinal cord is called glioma. Histologically gliomas are classified into astrocytoma, ependymoma, oligodendroglioma, brain stem glioma and oligoastrocytoma. The present study was conducted to study histological grading of gliomas and correlate it with patient’s age, sex, GFAP staining, role of the Ki-67/MIB-1 labelling indices (PIs). The present retrospective study was conducted on 50 biopsies received. All specimens were subjected to immunohistochemistory for GFAP and MIB-1 and correlated with WHO grading for glioma.: High incidence of glial tumours was seen in the 3 and 4 decade with slight male predominance (60%), with commonest site being frontal lobe. Glioblastomas (Grade IV) constitute the most common glial tumour. A statistically significant correlation was observed between GFAP staining and Ki-67/MIB-1 with histological grading.: The study can prove helpful in diagnosis and histological grading of gliomas and in planning treatment protocols and strategies.
A clinico-epidemiological hospital based study of oral cancer patients in Gwalior district
Authors: Tripathi Ankita , Agarwal Anil Kumar , Mahore Ramniwas , Bhadoriya Sumit S , Saraswat Swati 
Published: July 2021

Oral cancer is the most common form of carcinoma of oral cavity and ranks as the 12th most common cancer in the world. Oral cancer is one of the major social & health problems in India and Indian subcontinent countries. Tobacco use in different forms is the main etiological factor for oral carcinoma. (i) To define relations of oral cancer with respect to gender, age group, socioeconomic status and risk habits; (ii) To observe the distribution of affected oral cavity sites and observe the clinical profile in oral cancer patients.A cross-sectional study of 340 oral cancer patients from January 2019 to December 2019 was carried out in Department of oncology & radiotherapy, JA Group of hospital, G. R. Medical Gwalior, Madhya Pradesh India. Details of patient's sex, age, tobacco habit and site of cancer and status were noted. Data were analyzed by probability of patient with risk factors and chi-squire (χ) test. The prevalence of oral cancer was significantly (p &#60; 0.001) higher in males (91.5.9%) than females (8.5%). In both the sexes, most affected sites were the buccal mucosa and gingivo-buccal sulcus. However, the consuming form of tobacco was found to be significantly associated with oral cancer, in both sex. The study revealed that oral cancer is more common in men, probably due to habit of large tobacco consumption.
Cephalometric analysis for assessing sagittal jaw relationship- A comparative study
Authors: Bajjad Adeel Ahmed , Chauhan A K , Sharma Anil , Kumar Santosh 
Published: July 2021

The successful treatment of Orthodontic patient is dependent on careful diagnosis. Three planes of discrepancies are commonly described in orthodontics namely, transverse, sagittal and vertical. Of these, the sagittal discrepancies are most commonly encountered in day to day practice. This study was aimed to compare various methods of cephalometric analysis for assessing sagittal jaw relationship. There were total of 180 lateral cephalograms used and each samples were divided into 2 groups based on their skeletal relationship according to ANB angle. i.e Class I and Class II. Class I and Class II were again divided into average, horizontal and vertical group. Pretreatment records were taken and tracing were performed on the lateral cephalogram and measured values were recorded and subjected to statistical analysis.In class I, the highest frequency was seen in A-B plane angle and FABA angle and in class II the highest frequency found in K angle followed by A-B plane angle. In class I horizontal group, a strong level of agreement was found between AXB angle with AF-BF distance while in class II average group, A-B plane angle shows strong level of agreement with WITS and FABA angle. In terms of reliability, all the ten parameters (A-B plane angle, WITS, AF-BF distance, APP-BPP distance, FABA angle, BETA angle, YEN angle, W angle and K angle) show good reliability in class II average and vertical group. : No single measurement is perfect in all the cases. A combination of different measurements should be used to have a true assessment of sagittal jaw relationship.
Papa Francesco e Bartolomeo I: il fraterno impegno a favore di una spiritualità ecologica integrale
Authors: Farinola Onofrio 
Published: July 2021

Papież Franciszek i Bartłomiej I: braterskie zaangażowanie w integralną duchowość ekologiczną
Artykuł jest próbą ukazania założeń i rozwoju integralnego duszpasterstwa teoekologicznego w nauczaniu Franciszka i Bartłomieja I. Obaj pasterze są głęboko przekonani, że ekologia jest tematem głęboko ekumenicznym i międzyreligijnym. Autor analizuje różne aspekty ekolologii, odwołując się do specyficznej duchowości i teologii obu obrządków, zwracając uwagę na nowe podejście, jakim jest duszpasterstwo teoekologiczne. Artykuł kończy się wywiadem z Patriarchą Konstantynopola przeprowadzonym w 2017 roku, poświęconym zagadnieniom ochrony środowiska.

L'articolo è un tentativo di mostrare i presupposti e lo sviluppo di una pastorale teo ecologica integrale nell'insegnamento di Francesco e Bartolomeo I. Entrambi i pastori sono profondamente convinti che l'ecologia sia un argomento profondamente ecumenico e interreligioso. L'autore analizza vari aspetti dell'cologia, riferendosi alla spiritualità e ala teologia specifiche di entrambi i riti, evidenziando un nuovo approccio, quello della pastorale teo ecologica. L'articolo si conclude co un'intervista al Patriarca di Costantinopoli, condotta ne 2017, dedicata alle questioni ambientali.
Die personalistische Grundlage der kirchlichen Lehrverkündigung bezüglich der Personen mit lebensverkürzenden Erkrankungen
Authors: Kuciński Andrzej 
Published: July 2021

Personalistyczne podstawy nauczania Kościoła na temat osób z wadami letalnymi
Fala protestów po orzeczeniu polskiego Trybunału Konstytucyjnego z 22 października 2020 r. w sprawie niezgodności z konstytucją przesłanki o ciężkim i nieodwracalnym uszkodzeniu płodu jako wskazania do aborcji może być postrzegana jako wyzwanie dla Kościoła katolickiego do sprecyzowania swojego nauczania przyjaznego życiu w odniesieniu do ochrony najsłabszych oraz do podjęcia na nowo tego nauczania. Jedną z pomocy ku temu jest list Kongregacji Nauki Wiary Samaritanus bonus z 14 lipca 2020 r. Niniejszy artykuł odnosi się do wspomnianego nauczania doktrynalnego w celu syntezy i uzasadnienia reprezentowanego w nim stanowiska moralnego na temat aborcji, zwłaszcza w przypadku wad letalnych. Jego zasadą przewodnią jest personalistyczne spojrzenie na człowieka, zgodnie z którym osoba powinna znajdować się w centrum wszystkich decyzji etycznych. Z analizy poszczególnych aspektów postawionego problemu wyłaniają się pewne imperatywy etyczne, które są umieszczone we wnioskach końcowych.
Die Protestwelle nach dem Urteil des polnischen Verfassungsgerichts vom 22.10.2020 über die Verfassungswidrigkeit der embryopathischen Abtreibungsindikation kann für die katholische Kirche als Herausforderung betrachtet werden, ihre lebensbejahende Lehre im Hinblick auf den Schutz der Schwächsten zu verdeutlichen und neu zur Sprache zu bringen. Eine Stütze dafür bildet das Schreiben der Glaubenskongregation Samaritanus bonus vom 14.07.2020. Der vorliegende Artikel greift die besagte Lehrverkündigung auf, um die dort vertretene moralische Auffassung bzgl. der Abtreibung, insbesondere im Fall von lebensverkürzenden Krankheiten, zu synthetisieren und zu begründen. Leitend dafür ist die personalistische Sicht des Menschen, nach der die Person im Zentrum aller ethischen Entscheidung stehen soll. Aus der Betrachtung der einzelnen Aspekte der aufgeworfenen Frage ergeben sich bestimmte ethische Imperative, die in den Schlussfolgerungen betrachtet werden.
Ks. Ireneusz Mroczkowski (1949-2020) teolog moralista
Authors: Derdziuk Andrzej 
Published: July 2021

Ks. Ireneusz Mroczkowski (1949-2020) był teologiem moralistą zatrudnionym na KUL oraz na UKSW i innych uczelniach akademickich. Był aktywnym uczestnikiem życia Kościoła w Płocku jako rektor seminarium, członek Płockiego Towarzystwa Naukowego oraz redaktor „Studiów Płockich”. Pełnił posługę przewodniczącego Stowarzyszenia Teologów Moralistów w Polsce. W swojej twórczości naukowej zajmował się metodologią uprawiania nauki, antropologią teologicznomoralną, teologią ciała, małżeństwem i rodziną, feminizmem, prawami człowieka, moralnością życia społeczno-politycznego oraz ekologią. Zabierał też głos w sprawach wychowania seminaryjnego, kondycji Kościoła w Polsce, powołania i posłannictwa świeckich we współczesnym Kościele oraz aktualnego stanu świadomości moralnej. Był dobrym człowiekiem, który łączył prostą wiarę z dyscypliną rozumu i uczciwością serca.
A Fifth Mark of the Church?
Authors: Lancton Thaddaeus 
Published: July 2021

In addition to the four marks of the Church, mercy has been emphasized since the pontificate of St. John Paul II as essential to the authentic fulfillment of the Church’s identity and mission. A Christological and pneumatological understanding of these marks of the Church leads to a proper grasp of the Church in relation to mercy. The Church is merciful not de facto because of her works of mercy on behalf of the poor or sinners. Rather, she is first the recipient of unprecedented Divine Mercy, poured forth in the gift of the Holy Spirit, and so shares that same Spirit of Mercy with others through her sacraments, preaching, and service. The Church’s mission of mercy thus extends beyond the myriad of manners to alleviate human misery. In union with Christ, her Bridegroom, the Church is to communicate the one gift of Divine Mercy, the Holy Spirit, to all.
Relato de uma menina com cromossomo derivativo 4 resultante de translocação herdada paterna t(4:18)
Authors: Carvalho Natalia Dayane Moura , Prazeres Vania Mesquita Gadelha , Fantin Cleiton 
Published: July 2021

IntroduçãoTranslocação corresponde a troca de segmentos entre cromossomos não homólogos, decorrendo novas mutações ou herdadas. Na maioria dos casos, translocações estão associadas com cromossomo derivativo. Assim, objetivou-se relatar paciente com cariótipo 46,XX,der(4)t(4;18), resultante de translocação balanceada familiar entre cromossomos 4 e 18.Descrição do casoPaciente sexo feminino, 3 anos, filha única de casal não consanguíneo, apresentando fácies com hipertelorismo ocular discreto, ponte nasal alta, orelhas simplificadas e de abano, micrognatia, mãos com sobreposição de dedos, dificuldade de crescimento e ganho de peso, atraso no desenvolvimento psicomotor, refluxo gastroesofágico, alteração da deglutição e laringotraqueomalácia. O resultado de cariótipo da paciente revelou 46, XX,der(4)t(4;18)(q35;q12), mãe 46, XX e pai 46,XY,t(4;18)(q35;q12). Heredograma familiar foi construído.DiscussãoTais achados revelaram diagnóstico translocação balanceada familiar envolvendo os cromossomos 4 e 18, levando a trissomia parcial do cromossomo 4q. Isto é, o cromossomo 4 derivativo da paciente provavelmente teve ganho/perda de material genético da região q12 até a q23 do cromossomo 18. Análise citogenética foi primordial para o diagnóstico etiológico. ConclusãoPortanto, a análise citogenética/heredograma identificou a translocação balanceada familiar, permitindo melhor entendimento da etiopatologia além de centrado aconselhamento genético. Estudos citogenômicos/moleculares são necessários para elucidar o tipo e extensão das regiões cromossômicas.