bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic radiofrequency ablation or surveillance in patients with Barrett’s oesophagus with confirmed low-grade dysplasia: a multicentre randomised trial
Authors: Barret Maximilien , Pioche Mathieu , Terris Benoit , Ponchon Thierry , Cholet Franck , Zerbib Frank , Chabrun Edouard , Le Rhun Marc , Coron Emmanuel , Giovannini Marc , Caillol Fabrice , Laugier René , Jacques Jeremie , Legros Romain , Boustiere Christian , Rahmi Gabriel , Metivier-Cesbron Elodie , Vanbiervliet Geoffroy , Bauret Paul , Escourrou Jean , Branche Julien , Jilet Lea , Abdoul Hendy , Kaddour Nadira , Leblanc Sarah , Bensoussan Michael , Prat Frederic , Chaussade Stanislas 
Published: March 2021

ObjectiveDue to an annual progression rate of Barrett’s oesophagus (BO) with low-grade dysplasia (LGD) between 9% and 13% per year endoscopic ablation therapy is preferred to surveillance. Since this recommendation is based on only one randomised trial, we aimed at checking these results by another multicentre randomised trial with a similar design.DesignA prospective randomised study was performed in 14 centres comparing radiofrequency ablation (RFA) (maximum of 4 sessions) to annual endoscopic surveillance, including patients with a confirmed diagnosis of BO with LGD. Primary outcome was the prevalence of LGD at 3 years. Secondary outcomes were the prevalence of LGD at 1 year, the complete eradication of intestinal metaplasia (CE-IM) at 3 years, the rate of neoplastic progression at 3 years and the treatment-related morbidity.Results125 patients were initially included, of whom 82 with confirmed LGD (76 men, mean age 62.3 years) were finally randomised, 40 patients in the RFA and 42 in the surveillance group. At 3 years, CE-IM rates were 35% vs 0% in the RFA and surveillance groups, respectively (p<0.001). At the same time, the prevalence LGD was 34.3% (95% CI 18.6 to 50.0) in the RFA group vs 58.1% (95% CI 40.7 to 75.4) in the surveillance group (OR=0.38 (95% CI 0.14 to 1.02), p=0.05). Neoplastic progression was found in 12.5% (RFA) vs 26.2% (surveillance; p=0.15). The complication rate was maximal after the first RFA treatment (16.9%).ConclusionRFA modestly reduced the prevalence of LGD as well as progression risk at 3 years. The risk-benefit balance of endoscopic ablation therapy should therefore be carefully weighted against surveillance in patients with BO with confirmed LGD.Trial registration numberNCT01360541.
De novo TRPV4 Leu619Pro variant causes a new channelopathy characterised by giant cell lesions of the jaws and skull, skeletal abnormalities and polyneuropathy
Authors: Ragamin Aviel , Gomes Carolina C , Bindels-de Heus Karen , Sandoval Renata , Bassenden Angelia V , Dib Luciano , Kok Fernando , Alves Julieta , Mathijssen Irene , Medici-Van den Herik Evita , Eveleigh Robert , Gayden Tenzin , Pullens Bas , Berghuis Albert , van Slegtenhorst Marjon , Wilke Martina , Jabado Nada , Mancini Grazia Maria Simonetta , Gomez Ricardo Santiago 
Published: March 2021

BackgroundPathogenic germline variants in Transient Receptor Potential Vanilloid 4 Cation Channel (TRPV4) lead to channelopathies, which are phenotypically diverse and heterogeneous disorders grossly divided in neuromuscular disorders and skeletal dysplasia. We recently reported in sporadic giant cell lesions of the jaws (GCLJs) novel, somatic, heterozygous, gain-of-function mutations in TRPV4, at Met713.MethodsHere we report two unrelated women with a de novo germline p.Leu619Pro TRPV4 variant and an overlapping systemic disorder affecting all organs individually described in TRPV4 channelopathies.ResultsFrom an early age, both patients had several lesions of the nervous system including progressive polyneuropathy, and multiple aggressive giant cell-rich lesions of the jaws and craniofacial/skull bones, and other skeletal lesions. One patient had a relatively milder disease phenotype possibly due to postzygotic somatic mosaicism. Indeed, the TRPV4 p.Leu619Pro variant was present at a lower frequency (variant allele frequency (VAF)=21.6%) than expected for a heterozygous variant as seen in the other proband, and showed variable regional frequency in the GCLJ (VAF ranging from 42% to 10%). In silico structural analysis suggests that the gain-of-function p.Leu619Pro alters the ion channel activity leading to constitutive ion leakage.ConclusionOur findings define a novel polysystemic syndrome due to germline TRPV4 p.Leu619Pro and further extend the spectrum of TRPV4 channelopathies. They further highlight the convergence of TRPV4 mutations on different organ systems leading to complex phenotypes which are further mitigated by possible post-zygotic mosaicism. Treatment of this disorder is challenging, and surgical intervention of the GCLJ worsens the lesions, suggesting the future use of MEK inhibitors and TRPV4 antagonists as therapeutic modalities for unmet clinical needs.
Two tobacco retailer programmes in Banyuwangi, Indonesia: a qualitative study
Authors: Azzahro Eqia Arum , Dewi Desak Made Sintha Kurnia , Puspikawati Septa Indra , Handayani Rizky Putri , Ayodya Gayatri , Prayogi Ahmad Rido'i Yuda , Sebayang Susy K 
Published: March 2021

IntroductionThe tobacco retail density in Indonesia is very high, and tobacco companies are creative at promoting their products at point of sale (POS). The study explores the strategies employed by tobacco companies through their retailer programmes in Banyuwangi, Indonesia.MethodsIn 2019 we conducted observation and indepth interviews with the owners/keepers of 12 retailers with Sampoerna Retail Community (SRC) signs and 6 retailers with Gudang Garam Strategic Partnership signs placed as store names in front of their stores. We analysed the data to identify key strategies used by each tobacco company.ResultsGudang Garam promoted more visibility of their own products, while Sampoerna promoted their products in a power wall and also rearranged other products sold in the store to attract more customers. Sampoerna educated their retailers to attract and retain more customers by using schemes such as reward points and coupons. Sampoerna also developed and promoted the use of a mobile application for online sales.ConclusionsBoth programmes promote product and brand display at retailers to create brand loyalty. The SRC mobile application for online sales is potentially attractive to young customers and allows for data collection about retail and customer purchase behaviours that can be used for tailored marketing. Tobacco sales promotion strategies should be strongly regulated. Banning indoor tobacco advertisement, promotion and tobacco display at POS should be encouraged.
Exclusive dilepton production at forward rapidities in PbPb collisions
Authors: Goncalves V. P. , Martins D. E. , Rangel M. S. 
Published: March 2021

AbstractThe dilepton production at forward rapidities in diffractive and exclusive processes present in ultraperipheral PbPb collisions at the LHC is investigated. Predictions for the $$e^+ e^-$$

e
+

e
-

, $$\mu ^+ \mu ^-$$

μ
+

μ
-

and $$\tau ^+ \tau ^-$$

τ
+

τ
-

cross sections are presented taking into account of realistic cuts that can be implemented by the LHCb Collaboration in a future experimental analysis. Our results indicate that the background associated with the diffractive production can be strongly suppressed and the exclusive processes can be cleanly separated. For the $$\tau ^+ \tau ^-$$

τ
+

τ
-

production, the semi and purely leptonic decay channels are considered. Our results indicate that a future experimental analysis of the dilepton production at the LHCb is feasible and can be useful to search for BSM physics.
Measurement of the principal quantum number distribution in a beam of antihydrogen atoms
Authors: Kolbinger B. , Amsler C. , Cuendis S. Arguedas , Breuker H. , Capon A. , Costantini G. , Dupré P. , Fleck M. , Gligorova A. , Higaki H. , Kanai Y. , Kletzl V. , Kuroda N. , Lanz A. , Leali M. , Mäckel V. , Malbrunot C. , Mascagna V. , Massiczek O. , Matsuda Y. , Murtagh D. J. , Nagata Y. , Nanda A. , Nowak L. , Radics B. , Sauerzopf C. , Simon M. C. , Tajima M. , Torii H. A. , Uggerhøj U. , Ulmer S. , Venturelli L. , Weiser A. , Wiesinger M. , Widmann E. , Wolz T. , Yamazaki Y. , Zmeskal J. 
Published: March 2021

AbstractThe ASACUSA (Atomic Spectroscopy And Collisions Using Slow Antiprotons) collaboration plans to measure the ground-state hyperfine splitting of antihydrogen in a beam at the CERN Antiproton Decelerator with initial relative precision of$$10^{-6}$$10-6or better, to test the fundamental CPT (combination of charge conjugation, parity transformation and time reversal) symmetry between matter and antimatter. This challenging goal requires a polarised antihydrogen beam with a sufficient number of antihydrogen atoms in the ground state. The first measurement of the quantum state distribution of antihydrogen atoms in a low magnetic field environment of a few mT is described. Furthermore, the data-driven machine learning analysis to identify antihydrogen events is discussed.Graphic Abstract
Observational aspect of black hole dark matter
Authors: Stodolsky L. 
Published: March 2021

Advances in high angular resolution astronomy make it conceivable that black hole dark matter could be detected via angular deviation effects. Assuming the dark matter in the galaxy is made of solar mass black holes, there is a nontrivial probability that a line-of-sight through the galaxy, leads to [Formula: see text]’s deviations, a value that has been discussed for various astronomical projects. In cosmology, the effects are magnified by an increased density at early times and an opening of angles due to redshift. We stress the interest of the resolution in observations on the CMB and emphasize the distinction between this and the power spectrum. If the dark matter is made of primordial black holes, present at the CMB, random deflections of the CMB photons lead to a limit on the angular resolution, approximately [Formula: see text] rad, with [Formula: see text] the mass of the black holes. Using the resolutions of [Formula: see text] demonstrated in observations of the “acoustic peaks” then implies the limit [Formula: see text]. While this large value seems uninteresting, improved resolutions would lead to significant exclusion limits or conceivably the discovery of primordial black holes.
A Pogorelov estimate and a Liouville-type theorem to parabolic k-Hessian equations
Authors: He Yan , Sheng Haoyang , Xiang Ni , Zhang Jiannan 
Published: March 2021

We consider Pogorelov estimates and Liouville-type theorems to parabolic [Formula: see text]-Hessian equations of the form [Formula: see text] in [Formula: see text]. We derive that any [Formula: see text]-convex-monotone solution to [Formula: see text] when [Formula: see text] satisfies a quadratic growth and [Formula: see text] must be a linear function of [Formula: see text] plus a quadratic polynomial of [Formula: see text].
PETRA
Authors: Izadpanah Ramin , Peterson Christina , Solihin Yan , Dechev Damian 
Published: March 2021

Emerging byte-addressable Non-Volatile Memories (NVMs) enable persistent memory where process state can be recovered after crashes. To enable applications to rely on persistent data, durable data structures with failure-atomic operations have been proposed. However, they lack the ability to allow users to execute a sequence of operations as transactions. Meanwhile, persistent transactional memory (PTM) has been proposed by adding durability to Software Transactional Memory (STM). However, PTM suffers from high performance overheads and low scalability due to false aborts, logging, and ordering constraints on persistence.
In this article, we propose PETRA, a new approach for constructing persistent transactional linked data structures. PETRA natively supports transactions, but unlike PTM, relies on the high-level information from the data structure semantics. This gives PETRA unique advantages in the form of high performance and high scalability. Our experimental results using various benchmarks demonstrate the scalability of PETRA in all workloads and transaction sizes. PETRA outperforms the state-of-the-art PTMs by an order of magnitude in transactions of size greater than one, and demonstrates superior performance in transactions of size one.
Distribution of
α

p

2

Modulo One with Prime Variable
p
of a Special Form
Authors: Xue Fei , Li Jinjiang , Zhang Min 
Published: March 2021

Let

P

r

denote an almost-prime with at most

r

prime factors, counted according to multiplicity. In this paper, it is proved that, for

α
∈

ℝ
/
ℚ

,

β
∈
ℝ

, and

0
<
θ
<

10
/

1561

, there exist infinitely many primes

p

, such that

α

p

2

+
β

<

p

−
θ

and

p
+
2
=

P

4

, which constitutes an improvement upon the previous result.
Spectrum of Mechanisms of Resistance to Crizotinib and Lorlatinib in ROS1 Fusion–Positive Lung Cancer
Authors: Lin Jessica J. , Choudhury Noura J. , Yoda Satoshi , Zhu Viola W. , Johnson Ted W. , Sakhtemani Ramin , Dagogo-Jack Ibiayi , Digumarthy Subba R. , Lee Charlotte , Do Andrew , Peterson Jennifer , Prutisto-Chang Kylie , Malik Wafa , Hubbeling Harper G. , Langenbucher Adam , Schoenfeld Adam J. , Falcon Christina J. , Temel Jennifer S. , Sequist Lecia V. , Yeap Beow Y. , Lennerz Jochen K. , Shaw Alice T. , Lawrence Michael S. , Ou Sai-Hong Ignatius , Hata Aaron N. , Drilon Alexander , Gainor Justin F. 
Published: March 2021

Abstract

Purpose:
Current standard initial therapy for advanced, ROS proto-oncogene 1, receptor tyrosine kinase fusion (ROS1)-positive (ROS1+) non–small cell lung cancer (NSCLC) is crizotinib or entrectinib. Lorlatinib, a next-generation anaplastic lymphoma kinase/ROS1 inhibitor, recently demonstrated efficacy in ROS1+ NSCLC, including in crizotinib-pretreated patients. However, mechanisms of lorlatinib resistance in ROS1+ disease remain poorly understood. Here, we assessed mechanisms of resistance to crizotinib and lorlatinib.

Experimental Design:
Biopsies from patients with ROS1+ NSCLC progressing on crizotinib or lorlatinib were profiled by genetic sequencing.

Results:
From 55 patients, 47 post-crizotinib and 32 post-lorlatinib biopsies were assessed. Among 42 post-crizotinib and 28 post-lorlatinib biopsies analyzed at distinct timepoints, ROS1 mutations were identified in 38% and 46%, respectively. ROS1 G2032R was the most commonly occurring mutation in approximately one third of cases. Additional ROS1 mutations included D2033N (2.4%) and S1986F (2.4%) post-crizotinib and L2086F (3.6%), G2032R/L2086F (3.6%), G2032R/S1986F/L2086F (3.6%), and S1986F/L2000V (3.6%) post-lorlatinib. Structural modeling predicted ROS1L2086F causes steric interference to lorlatinib, crizotinib, and entrectinib, while it may accommodate cabozantinib. In Ba/F3 models, ROS1L2086F, ROS1G2032R/L2086F, and ROS1S1986F/G2032R/L2086F were refractory to lorlatinib but sensitive to cabozantinib. A patient with disease progression on crizotinib and lorlatinib and ROS1 L2086F received cabozantinib for nearly 11 months with disease control. Among lorlatinib-resistant biopsies, we also identified MET amplification (4%), KRAS G12C (4%), KRAS amplification (4%), NRAS mutation (4%), and MAP2K1 mutation (4%).

Conclusions:
ROS1 mutations mediate resistance to crizotinib and lorlatinib in more than one third of cases, underscoring the importance of developing next-generation ROS1 inhibitors with potency against these mutations, including G2032R and L2086F. Continued efforts are needed to elucidate ROS1-independent resistance mechanisms.
Diagnosing MERS-CoV using dempster-shafer method
Authors: Akbar Memen , Hidayat Fandy , Novayani Wenda 
Published: March 2021

<span lang="EN-US">MERS-CoV (Middle East Respiratory Syndrome-Coronavirus) is a respiratory syndrome disease caused by the coronavirus which attacks the respiratory tract from mild to severe. MERS-CoV was first reported in Saudi Arabia; total cases of MERS-CoV have continued to increase. In Indonesia, the MERS-CoV enters through the pilgrimage of Hajj and Umrah. But not many people know about this disease and its symptoms. For this reason, an expert system was developed to diagnose MERS-CoV using the Dempster-Shafer method. The system can detect the disease from the symptoms inputted by user. The output of the system is the value of the probability of the disease, the level of the disease and the suggested. The levels of the disease are Stage 1, Stage 2, and Stage 3 where each has a different treatment based on the level of the disease. The system contains information about MERS-CoV in the form of videos and text. The system was built using the PHP programming language. The testing result shows that all system functionalities have been fulfilled. The expert validation testing had obtained at 76.7%, which prove that the system is good enough in diagnosing MERS-CoV and the results obtained from the questionnaire is at an average of 84.13% which is very good in helping users in diagnosing disease. The expert system that has been developed can help people in diagnosing the disease before consulting with a doctor.</span>MERS-CoV (Middle East Respiratory Syndrome-Coronavirus) is arespiratory syndrome disease caused by the coronavirus which attacks therespiratory tract from mild to severe. MERS-CoV was first reported in SaudiArabia; total cases of MERS-CoV have continued to increase. In Indonesia,the MERS-CoV enters through the pilgrimage of Hajj and Umrah. But notmany people know about this disease and its symptoms. For this reason, anexpert system was developed to diagnose MERS-CoV using the DempsterShafer method. The system can detect the disease from the symptomsinputted by user. The output of the system is the value of the probability ofthe disease, the level of the disease and the suggested. The levels of thedisease are Stage 1, Stage 2, and Stage 3 where each has a different treatmentbased on the level of the disease. The system contains information aboutMERS-CoV in the form of videos and text. The system was built using thePHP programming language. The testing result shows that all systemfunctionalities have been fulfilled. The expert validation testing had obtainedat 76.7%, which prove that the system is good enough in diagnosing MERSCoV and the results obtained from the questionnaire is at an average of84.13% which is very good in helping users in diagnosing disease. Theexpert system that has been developed can help people in diagnosing thedisease before consulting with a doctor.<div> </div>
New record of Lissoporcellana demani Dong & Li, 2014 (Decapoda, Anomura, Galatheoidea, Porcellanidae) from southeast Africa
Authors: Dong Dong , Kazmi Quddusi B. , Siddiqui Feroz A. 
Published: March 2021

Abstract
The porcellanid crab Lissoporcellana demani Dong & Li, 2014 is reported for the first time from southeast Africa, based on material collected from trawls off Mozambique during the International Indian Ocean Expedition in 1963-1964. Lissoporcellana demani has been known only from the western Pacific, and the present specimens greatly extend the previously known distribution range of this species to the western Indian Ocean. Illustrations of a specimen are provided. Morphological variations of L. demani and characters distinguishing it from closely related congeneric species are discussed.
Positive association between experimental cortisol increases and cage-measures of feeding behavior in wild-caught gerbils
Authors: Sargunaraj Franklin , St. Juliana Justin R. , Downs Cynthia J. , Khokhlova Irina S. , Koren Lee , Matas Devorah , Wynne-Edwards Katherine E. , Kotler Burt P. 
Published: March 2021

Abstract
Glucocorticoid hormone levels vary within a forager based upon environmental stressors such as illumination and riskier habitats, and a forager’s response to environmental variables depends upon its glucocorticoid levels. Here, we report on a laboratory experiment in which we manipulated cortisol in Allenbyi’s gerbils (Gerbillus andersoni allenbyi) to test the relationship between cortisol and behavior. We then quantified the resulting blood cortisol levels and feeding behavior in gerbils. Thirty gerbils were injected with 21-day slow-release cortisol pellets drawn from 5 different dosages. We quantified the physiological response to pellet implantation in gerbils by measuring cortisol level in blood serum using ELISA (Enzyme Linked Immunosorbent Assay). We fed gerbils daily by mixing millet seeds into the sand inside rodent cages and measured the remaining seeds the following day to quantify feeding efforts. Some evidence supports that subcutaneous supplementation of glucocorticoids (GCs) in the gerbils led to higher blood serum levels. Cortisol levels varied according to time period of measurement. Gerbils that received lower dosages consumed most of the food presented to them when compared to those receiving the highest doses. In this manner, we delineate a pattern on cortisol hormone level variation over time following dosing and consequences in feeding behavior.
Role of Baroclinic Trough in Triggering Vertical Motion during Summertime Heavy Rainfall Events in Korea
Authors: Park Chanil , Son Seok-Woo , Kim Jung-Hoon 
Published: March 2021

AbstractThe nature of the vertical motion responsible for the summertime heavy rainfall events (HREs) in South Korea is quantitatively examined. By compositing 318 HREs from June to September in 1979–2018, it is found that the synoptic conditions of the HREs are typically characterized by a developing surface cyclone with a southwesterly low-level jet on its southeastern flank and an upper-level trough to the west of the HREs. This baroclinic environment allows for well-organized vertical motion over South Korea at the equatorward side of the upper-level jet entrance. The relative importance of dynamic and diabatic forcings in driving the vertical motion is further quantified by solving the quasigeostrophic omega equation. It turns out that the dynamic forcing, defined as Q-vector convergence, is comparable to the diabatic forcing in the developing stage of the HREs. The diabatic forcing, however, becomes more important in the mature stage as latent heating rapidly increases. The decomposition of the Q vector into the transverse (cross-isentropic) and shearwise (along-isentropic) components reveals that the dynamic uplift is largely caused by the shearwise Q-vector convergence, which is closely related to the developing trough in the upper to middle troposphere on the west of the HREs. This result indicates that the HREs in South Korea are organized by the baroclinic trough coupled to moist processes, with a minor contribution of the thermally direct secondary circulation at the entrance region of the upper-level jet.