bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEG-BCT-100 in Combination With Capecitabine and Oxaliplatin (PACOX) in Patients With Advanced Hepatocellular Carcinoma: A Phase I Study Results
Authors: Yau Thomas , Cheng Paul N.M. , Chiu Joanne , Kwok Gin Wai , Leung Roland , Liu Angela M , Cheung Tan To , Ng Chi Tao 
Published: July 2021

Abstract
Introduction: We investigated the safety and efficacy of PEG-BCT-100 in combination with oxaliplatin and capecitabine (PACOX) in advanced HCC patients.Methods: This was a single centre phase 1 trial to assess the safety and tolerability of PACOX. All the enrolled subjects received treatment in 3-weekly cycles: IV PEG-BCT-100 2.7 mg/kg on day 1, 8 and 15 of each cycle; oral capecitabine 1000 mg/m2 twice daily on day 1-14 of each cycle and IV oxaliplatin on day 1. Three dose levels of oxaliplatin (85 mg/m2, 100 mg/m2 or 130 mg/m2) were studied to define the maximum tolerated dose (MTD). Adverse events (AEs), efficacy by RECIST v1.1, time to progression (TTP), progression-free survival (PFS) and overall survival (OS) were studied.Results: Seventeen patients were enrolled at 3 doses of oxaliplatin: 85 mg/m2 (8 patients), 100 mg/m2 (3 patients), and 130 mg/m2 (6 patients). The median age was 55 years; all had local-regional chemotherapy or target therapy such as sorafenib, but no systemic chemotherapy. Most common AEs were nausea (82%), injection site reaction (76%), palmar-plantar erythrodysesthesia (59%), oral mucositis (53%) and vomiting (53%). There was no dose-limiting toxicity (DLT). Median duration on study was 8 weeks overall. In 14 evaluable cases, one achieved partial response (PR), 4 had stable disease (SD); disease control rate was 36% (5/14); most responses were observed in the 130 mg/m2 cohort with 1 PR and 2 SDs (3/6 or 50%). The median TTP, PFS were both 7.0 weeks. Overall median OS was 10.7 months; the median OS was not reached at 19.4 months of follow-up in the third cohort.Conclusion: The PACOX regimen demonstrated good anti-cancer activity and survival advantage in advanced pre-treated HCC with favourable safety profile. It warrants further phase II/III studies.
Increased Soil Fertility in Tea Plantations Leads to Declines in Fungal Diversity and Complexity in Subsoils
Authors: yan peng , Shen Chen , Zou Zhenhao , Fan Lichao , Li Xin , Zhang Liping , Zhang Lan , Dong Chunwang , Fu Jianyu , Han Wenyan , Shi Lingling 
Published: July 2021

Abstract
Purpose The effects of fertilization of tea plantations on soil quality and the diversity and composition of microbial communities have received increased attention in recent years. Despite their important role as decomposers of organic matter, the responses of soil fungi to fertilization and soil fertility, particularly in subsoils, remain unknown. In this study, the effects of land-use change and fertilization on fungal diversity and function in both of topsoil and subsoils were evaluated.Methods We sampled soil profiles (0–60 cm) from tea plantations in southeastern China with low, moderate, and high inputs of mineral and organic fertilizers, as well as a nearby natural (unfertilized) forest. 18s rRNA Illumina sequencing was used to evaluate how soil fertility and land-use impacted fungal diversity and function. Results Following conversion from forest to tea plantation, soil fungal diversity increased with fertility in topsoil but declined in subsoils, resulting in significant vertical variation in highly fertile soils. The dominant fungal groups shifted from Solicoccozyma and Trichoderma in the forest to Pseudogymnoascus and Umbelopsis in tea plantation soils. Relative abundance of Pseudogymnoascus increased with soil fertility, while Mortierella and opportunistic saprotrophs exhibited the opposite pattern. Fungal network complexity was enhanced in topsoil under increased soil fertility, but decreased in the subsoil, suggesting an increased selective effect along the soil horizon. Land-use changes have altered the dominant fungal groups, particularly in topsoil. Soil fertility not only regulated fungal diversity but also shifted community composition toward that found in the forest. With increased soil fertility, plants have a greater influence on the soil fungal community.
A double-hit in vivo model of GBA viral microRNA-mediated downregulation and human alpha-synuclein overexpression demonstrates nigrostriatal degeneration
Authors: Polissidis Alexia , Nikolopoulou Georgia , Koronaiou Effrosyni , Nikatou Maria , Viel Catherine , Bogiongko Marios , Sardi S. Pablo , Xilouri Maria , Vekrellis Kostas , Stefanis Leonidas 
Published: July 2021

Abstract
Background: Preclinical and clinical studies support a strong association between mutations in the GBA1 gene that encodes beta-glucocerebrosidase (GCase) (EC 3.2.1.45; glucosylceramidase beta) and Parkinson’s disease (PD). Alpha-synuclein (AS), a key player in PD pathogenesis, and GBA1 mutations may independently and synergistically cause lysosomal dysfunction and thus, embody clinically well-validated targets of the neurodegenerative disease process in PD. However, double-hit in vivo models, recapitulating pathological features of PD that can be used to dissect the nature of the complex relationship between GCase and AS on the nigrostriatal axis, the region particularly vulnerable in PD, are direly needed. Methods: To address this, we implemented a bidirectional approach in mice to examine the effects of: 1) GCase overexpression (wild-type and mutant N370S) on endogenous AS levels and 2) downregulation of endogenous GCase combined with AS overexpression. Results: Striatal delivery of viral-mediated GCase overexpression revealed minimal effects on cortical and nigrostriatal AS tissue levels and no significant effect on dopaminergic system integrity. On the other hand, microRNA (miR)-mediated GBA1 downregulation (miR GBA), combined with virus-mediated human AS overexpression (+AS), yields decreased GCase activity in the cortex, mimicking levels seen in GBA1 heterozygous carriers (30-40%), increased astrogliosis and microgliosis, decreased striatal dopamine levels (50% compared to controls) and loss of nigral dopaminergic neurons (~33%)- effects that were all reversible with miR rescue. Most importantly, the synergistic neurodegeneration of miR GBA+AS correlated with augmented AS accumulation and extracellular release in the striatum. Conclusion: Collectively, our results suggest that GCase downregulation alone is not sufficient to recapitulate key pathological features of PD in vivo, but its synergistic interplay with AS, via increased AS levels and release, drives nigrostriatal neurodegeneration. Furthermore, we demonstrate a novel double-hit model that can be used to identify putative mechanisms driving PD pathophysiology and can be subsequently used to test novel therapeutic approaches.
The Improved Techniques of Holding the Lens in Endoscopic Thyroidectomy via Bilateral Areola Approach
Authors: wang junxiao , Lin Qisheng , Wu Xiaolan , Lin Yuxiang , liu ezhang 
Published: July 2021

Abstract
Background: Inexperienced endoscope holder often greatly affect the time and quality of endoscopic thyroidectomy (ET) via bilateral areola approach. We summarized some techniques of holding the endoscopic lens to evaluate the value of the technique in ET.Methods: We retrospectively enrolled 200 eligible patients during two time peroids: 2015.6-2018.6 (Control group:inexperienced endoscope holder,n = 100) and 2019.9-2021.2 (Improved group:assistants who master the techniques of holding the endoscopic lens,n = 100). Surgery approach:unilateral lobectomy and isthmus resection plus ipsilateral cervical central lymph nodes dissection via bilateral areola approach of ET. Perioperative indicators included Volume of intraoperative blood loss,the time of three stages in the operation, the indwelling time of drainage tube and postoperative hospitalization time were compared. Postoperative complications were simultaneously compared involved temporary hoarseness, tetany, postoperative bleeding, postoperative infection and postoperative subcutaneous effusion.Results: The time of stage 1 (p < 0.001), stage 2 (p < 0.001) and stage 3 (p < 0.001) in the operation in improved group were significantly shorter than those in control group. The volume of intraoperative blood loss was smaller (p < 0.001), postoperative hospitalization time was shorter (p < 0.001) and the indwelling time of drainage tube was shorter (p < 0.001) for improved group. In terms of postoperative complications, the control group had more cases of temporary hoarseness (p = 0.002), tetany (p = 0.008) and postprocedure subcutaneous effusion (p = 0.009), but there was no difference in postoperative bleeding (p = 0.477) and infection (p = 1.000) between the two groups.Conclusions: The skills of holding the endoscopic lens which shorten the operation time and improve the quality of the operation are effective and suitable for novices.
Study on the techniques of wallpaper (“Biaohu”) in the Palace Museum: Case on Lodge of Bamboo Fragrance(Zhu Xiangguan)
Authors: Yue Ma , Zhao Congshan , Lei Yong 
Published: July 2021

Abstract
"Biao Hu" was one of the eight famous traditional crafts in the late Qing dynasty.Its function was decorating the interior of ancient buildings and making burial objects, including ceilings, walls and windows. It was popular in the buildings of northern China in the early Qing dynasty. There were white and patterned wallpaper in the Forbidden City, the latter included traditional and rare patterns in the Palace. Take the wallpaper in Lodge of Bamboo Fragrance( Zhuxiang Guan ) as an example, in this article, its structure and composition are studied by morphological observation and spectral analysis. Combined with the analysis of the patterned wallpaper in other buildings of the Forbidden City, the traditional technology is studied .
Seismic Performance of Prefabricated Beam-to-column Joint with Replaceable Energy-dissipating Steel Hinge
Authors: Zheng Lianqiong , Chen Xiaoyang , Wei Changgui , Yan Guiyun 
Published: July 2021

Abstract
This study presents a novel energy-dissipating prefabricated joint for connecting beam to column in a precast frame structure. The joints are characterized by a replaceable steel hinge and a prefabricated steel tube confined joint core, providing advantages for precast concrete reinforced frames, such as complete assembly, damage control, and maintainability of the structure after an earthquake. The hysteretic behavior of the proposed prefabricated joint was studied through two tests. First, a full-scale prefabricated joint was tested under cyclic loading until failure. On the basis of the initial test, only four weakened dissipaters of the steel hinges in the prefabricated joint were replaced and the second test was conducted to investigate the restorable functional characteristics of the proposed prefabricated joints. For comparison, a reference monolithic joint was also tested. The experimental results demonstrate that the novel prefabricated beam-to-column joint displayed excellent hysteretic performance, and corresponding to the monolithic joint, the load-bearing, energy dissipation, and deformation capacity were improved. The damage of the prefabricated joint was concentrated on the weakened dissipaters of the steel hinges, indicating that the failure mode and damage degree of the prefabricated joint can be controlled. In the second test, the prefabricated joint exhibited similar hysteretic behavior to that of the first test; however, the initial stiffness was slightly lower. Therefore, the prefabricated joint can meet the replaceability requirement and achieve satisfactory beam-to-column joint function recovery after an earthquake.
Study Protocol: Traditional Chinese Medicine (TCM) Syndrome Differentiation for Heart Failure patients and its Implication for Long-term Therapeutic Outcome of Qiliqiangxin Capsules
Authors: Leung Alice Yeuk Lan , Chen Hoiyong , Jia Zhenhua , Li Xinli , Shen Jiangang 
Published: July 2021

Abstract
BackgroundSyndrome differentiation is a commonly used methodology and practice in Traditional Chinese Medicine (TCM) guiding the diagnosis and treatment of diseases including heart failure (HF). However, previous clinical trials seldom consider the impact of syndrome patterns on the outcome evaluation of TCM formulae. Qiliqiangxin (QLQX) capsule is a TCM formula with cardiotonic effect to improve the cardiovascular function for heart failure with proven efficacy from well-designed clinical trials. Though, there is no clinical trial with a large sample size and long assessment period that considers the relationship between TCM syndrome differentiation and the treatment efficacy of QLQX. In the present study, we design a study protocol to evaluate the relationship between TCM syndrome differentiation and the severity of heart failure as well as its progression. Furthermore, we will evaluate the impact of the TCM syndrome patterns on the efficacy of QLQX in the outcome of heart failure. MethodsThis is a clinical study conducted in conjunction with an ongoing clinical trial (QUEST Study 1 ) to evaluate the efficacy of QLQX to improve the outcome of HF treatment through the assessment of morbidity and re-hospitalization, which involves over 100 hospitals in mainland China and Hong Kong SAR with 3,080 HF patients. Firstly, we will apply a modified TCM Questionnaire to collect the clinical manifestations of HF and acquire the tongue images of the patients to facilitate the syndrome differentiation. We will base on the “2014 Consensus from TCM experts on diagnosis and treatment of chronic heart failure” to evaluate the TCM syndromes for the patients. Secondly, we will investigate the characteristic of TCM syndrome distribution of HF patients and its correlation with the functional and biochemical data. Furthermore, we will evaluate the relationship between the TCM syndrome patterns and the efficacy of QLQX in the treatment of heart failure. Lastly, we will investigate the implication of tongue diagnosis in the severity and therapeutic outcome of HF. Expect OutcomesTo our knowledge, this will be the latest and well-designed clinical trial to evaluate the rules of TCM syndrome differentiation in the progression and therapeutic outcome of HF patients. We expect to obtain direct clinical evidence to verify the importance of TCM syndrome differentiation for the diagnosis and treatment of HF.Trial Registration1The trial was registered at Chinese Clinical Trial Registry, http://www.chictr.org.cn. (Registration No.: ChiCTR1900021929); Date: 2019-03-16.
A Rare Case of Right Upper Lung Cancer With Azygos Lobe and Partial Anomalous Pulmonary Venous Return: A Case Report
Authors: SU Xiaoyang , Huang Qianzhun , Luo Zhiqiang , Fang Ning , Huang Jian 
Published: July 2021

Abstract
Background: The azygos lobe (AL) combined with partial anomalous pulmonary venous return (PAPVR) is comparatively uncommon as well as in radical surgery for right lung cancer.Case presentation: We herein present an extremely rare case of lung cancer coexisting with AL and asymptomatic PAPVC, which was diagnosed with preoperative contrast three-dimensional reconstruction and received radical surgery by thoracoscopy. During the surgery, we preserved azygos vein successfully and found a split type of PAPVR in right upper pulmonary vein.Conclusions: AL combined with PAPVR may cause confusion on the vascular separation and disconnection of the right pulmonary hilar. However, preoperative 3D reconstruction are more conducive to the correct performing of this type of surgery.
Clinical Outcomes of Limited-repair Strategy and Conservative Approach for the Elderly With Acute Type A Aortic Dissection
Authors: Maze Yasumi , Tokui Toshiya , Murakami Masahiko , Nakamura Bun , Inoue Ryosai , Hirano Reina , Hirano Koji 
Published: July 2021

Abstract
BackgroundThere is controversy regarding surgical indication and surgical procedure of acute type A aortic dissection for the elderly. We examined surgical outcomes for the elderly.MethodsFrom January 2012 to December 2019, 174 patients underwent surgical repair for acute type A aortic dissection. We compared the surgical outcomes between the elderly group (≧80 years old) and the non-elderly group (≦79 years old). Additionally, we compared the surgical treatment group with the conservative treatment group.ResultsThe primary entry was found in the ascending aorta in 51.6% of the elderly group and in 32.8% of the non-elderly group (p= 0.049). In the elderly group, ascending or hemiarch replacement was performed in all cases, while in the non-elderly group, ascending or hemiarch replacement was performed in 57.3% (p<0.001). The hospital mortality was similar in both groups. The 5-year survival rate was 48.4±10.3% in the elderly group and 86.7±2.9% in the non-elderly group (p<0.001). The rates of freedom from aortic event at 5 years was 86.9±8.7% in the elderly group and 86.5±3.9% in the non-elderly group (p=0.771). The 5-year survival rate of conservative treatment group was 19.2±8.0% in the elderly. There was no significant difference from the surgical treatment group (p=0.103).ConclusionsThe surgical approach may not always be the reasonable treatment of choice for the elderly because the significant survival merit was not achieved compared with the conservative approach.
Magnetic Composite of γ-Fe2O3 Hollow Sphere and Palladium Doped Nitrogen-rich Mesoporous Carbon as a Recoverable Catalyst for C-C Coupling Reactions
Authors: Malmir Masoume , Heravi Majid M. , Amiri Zahra , Kafshdarzadeh Kosar 
Published: July 2021

Abstract
In this article, Palladated-magnetic nitrogen doped porous carbon was prepared from nano magnetic γ-Fe2O3 hollow sphere (h-Fe2O3) with high specific surface area and pore volume. To the purpose, initially h-Fe2O3 was prepared and covered with glucose via hydrothermal treatment with subsequent polymerization of organic shell. The polymerization of melamine-resorcinol-formaldehyde (MRF) was achieved in the presence of Cl-functionalized glucose coated h-Fe2O3 (h-Fe2O3@glu-MRF). Next, the prepared magnetic core-shell hollow sphere was palladated followed by carbonization to yield Pd@h-Fe2O3@C introducing more pores in its structure. The resulted compound, Pd@h-Fe2O3@C, was fully characterized, showing that carbonization process expressively increased the specific surface area. The resulted Pd@h-Fe2O3@C was successfully used for promoting C-C coupling reactions under mild reaction conditions as a heterogeneous catalyst and its activity was compared with some prepared control catalysts. This novel catalyst was magnetically separated simply by a magnet bar and recycled and reused at least in five consecutive runs, without considerable loss of its activity. It is note mentioning that, high recyclability with low Pd leaching are another gains of this protocol.
Analysis and Prediction of Sulfate Erosion Damage of Concrete in Service Tunnel based on ARIMA Model
Authors: Liu Dunwen , Chen Haofei , Tang Yu , Chun Gong , Jian Yinghua , Cao Kunpeng 
Published: July 2021

Abstract

Sulfate erosion is a major cause of concrete durability deteriorations, especially for the service tunnels which are in sulfate erosion for a long time. Accurately predicting the concrete damage failure under sulfate erosion has been a challenging problem in the evaluation and maintenance of concrete structures. Here we design the dry-wet cycle test of service tunnel concrete under sulfate erosion, and analyze the Elastic relative dynamic modulus(Erd) and mass under 35 times cycle periods. Then we develop an autoregressive integrated moving average (ARIMA) prediction model linking damage failure to Erd and mass. The results show that the deterioration of concrete first increased and then decreased with an extension of the dry–wet cycle period. Moreover, based on a finite set of training data, the proposed prediction approach shows high accuracy for the changes of concrete damage failure parameters in or out of the training dataset. The ARIMA method is proven to be feasible and efficient for predicting the concrete damage failure of service tunnel under sulfate erosion for a long time.
Oral Supplementation With Selected Lactobacillus Acidophilus Triggers Antimicrobial Response, Activation of Innate Lymphoid Cells Type 3 And Improves Colitis
Authors: Hrdý Jiří , Couturier-Maillard Aurélie , Boutillier Denise , Lapadatescu Carmen , Blanc Philippe , Pot Bruno , Ryffel Bernhard , Grangette Corinne , Chamaillard Mathias 
Published: July 2021

Abstract
Live biotherapeutic products constitute an emerging therapeutic approach to prevent or treat inflammatory bowel diseases. Lactobacillus acidophilus is a constituent of the human microbiota with probiotic potential, that are illustrated by direct and indirect antimicrobial activity against several pathogens and improvement of intestinal inflammation. In this study, we evaluated the anti-inflammatory properties of the L. acidophilus strain BIO5768 and assessed the underlying mechanisms of action. BIO5768 was able to counteract the acute colitis that is induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS). When administered alone or in combination with Bifidobacterium animalis spp. lactis BIO5764 and Limosilactobacillus reuteri, BIO5768 was also able to alleviate intestinal inflammation induced by Citrobacter rodentium infection. Supplementation of naïve mice with either strain BIO5768 alone or as mixture, increased the gene expression of several target genes involved in immune signaling, including c-type lectin Reg3 gamma. Consistently, the ability of innate lymphoid cells to secrete IL-22 was enhanced in response to BIO5768. Interestingly, the aforementioned responses were shown to be independent of NOD2 and Th17 signaling in mice that were mono-colonized with BIO5768. In conclusion, we identify a new potential probiotic strain with the ability for the management of inflammatory bowel diseases, and provide some insights into its mode of action.