bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting postoperative epilepsy surgery satisfaction in adults using the 19‐item Epilepsy Surgery Satisfaction Questionnaire and machine learning
Authors: Josephson Colin B. , Engbers Jordan D. T. , Sajobi Tolulope T. , Wahby Sandra , Lawal Oluwaseyi A. , Keezer Mark R. , Nguyen Dang K. , Malmgren Kristina , Atkinson Mark J. , Hader Walter J. , Macrodimitris Sophia , Patten Scott B. , Pillay Neelan , Sharma Ruby , Singh Shaily , Starreveld Yves , Wiebe Samuel 
Published: July 2021

ABSTRACTObjectiveThe 19‐item Epilepsy Surgery Satisfaction Questionnaire (ESSQ‐19) is a validated and reliable post hoc means of assessing patient satisfaction with epilepsy surgery. Prediction models building on these data can be used to counsel patients.MethodsThe ESSQ‐19 was derived and validated on 229 patients recruited from Canada and Sweden. We isolated 201 (88%) patients with complete clinical data for this analysis. These patients were adults (≥18 years old) who underwent epilepsy surgery 1 year or more prior to answering the questionnaire. We extracted each patient’s ESSQ‐19 score (scale is 0–100; 100 represents complete satisfaction) and relevant clinical variables that were standardized prior to the analysis. We used machine learning (linear kernel support vector regression [SVR]) to predict satisfaction and assessed performance using the R2 calculated following threefold cross‐validation. Model parameters were ranked to infer the importance of each clinical variable to overall satisfaction with epilepsy surgery.ResultsMedian age was 41 years (interquartile range [IQR] = 32–53), and 116 (57%) were female. Median ESSQ‐19 global score was 68 (IQR = 59–75), and median time from surgery was 5.4 years (IQR = 2.0–8.9). Linear kernel SVR performed well following threefold cross‐validation, with an R2 of .44 (95% confidence interval = .36–.52). Increasing satisfaction was associated with postoperative self‐perceived quality of life, seizure freedom, and reductions in antiseizure medications. Self‐perceived epilepsy disability, age, and increasing frequency of seizures that impair awareness were associated with reduced satisfaction.SignificanceMachine learning applied postoperatively to the ESSQ‐19 can be used to predict surgical satisfaction. This algorithm, once externally validated, can be used in clinical settings by fixing immutable clinical characteristics and adjusting hypothesized postoperative variables, to counsel patients at an individual level on how satisfied they will be with differing surgical outcomes.
Clinical phenotypes within nonconvulsive status epilepticus
Authors: Lattanzi Simona , Giovannini Giada , Brigo Francesco , Orlandi Niccolò , Trinka Eugen , Meletti Stefano 
Published: July 2021

AbstractThe study aimed to identify distinct phenotypes within nonconvulsive status epilepticus (NCSE). Consecutive episodes of NCSE in patients at least 14 years old were included. The level of consciousness was assessed through the Glasgow Coma Scale (GCS). Etiology of NCSE was defined as symptomatic (acute, remote, progressive) or unknown. Electroencephalographic (EEG) recordings were searched for lateralized periodic discharges (LPDs), generalized sharply and/or triphasic periodic potentials (GPDs), and spontaneous burst suppression (BS). According to treatment response, NCSE was classified as responsive, refractory, or superrefractory. Average linkage hierarchical cluster analysis was performed with Pearson correlation as similarity measure. Two hundred twenty‐nine episodes of NCSE were included. Three clusters were identified. The first cluster linked GCS score 3–8, presence of spontaneous BS on EEG, acute symptomatic etiology, and treatment superrefractoriness. The second cluster gathered GCS score 9–12, presence of LPDs or GPDs on EEG, unknown etiology, and treatment refractoriness. The third cluster associated GCS score 13–15, absence of LPDs, GPDs, and spontaneous BS on EEG, and progressive and remote symptomatic etiology with treatment responsiveness. Phenotyping the heterogeneity of NCSE into electroclinical clusters can contribute to understanding correlations between pathologic and clinical domains, assessing the intrinsic severity of NCSE episodes, and estimating the likelihood of treatment responsiveness.
Vervet monkeys socialize more when time budget constraints are experimentally reduced
Authors: Borgeaud Christèle , Jankowiak Béatrice , Aellen Mélisande , Dunbar Robin I.M. , Bshary Redouan 
Published: July 2021

AbstractIn species that live in stable groups, successful management of time budget (i.e., the proportion of time involved in different behaviours) and social relationships has been proposed to be a key variable affecting individual fitness. Such management is limited by time constraints, which are group size and season dependancy. However, the link between time budget constraints and grooming patterns as a means to service social relationships has never been studied experimentally. Here, we reduced the time constraints of three wild vervet monkey (Chlorocebus aethiops pygerythrus) groups by offering them high quality food for 60 min in the morning. We conducted 10 trials in summer and 10 trials in winter. We found that vervet monkeys indeed reduced the proportion of time spent foraging during the rest of those days compared to control days and increased the proportion of grooming time spread over more bouts. Individuals that did not get access to the food still participated as much in grooming as those that did eat. In accordance with our expectations, social network analysis revealed a larger grooming network on supplementation days: vervet monkeys used their extra time to socialize with more different group members. Furthermore, following our predictions, the effect of provisioning was usually stronger during the winter season (when food was scarce and days shorter) than during the summer, and the number of conflicts decreased during supplementation days. Finally, despite the fact that adults and juveniles of all three groups increased their proportion of time spent grooming during supplementation days, few group and age differences emerged in the way vervet monkeys manage their time budget. Interestingly, some of these differences seem to be independent of group size. In conclusion, vervet monkeys seize the opportunity to increase the proportion of time spent in social behaviours if time budget constraints are reduced.
Cysteine residues in the fourth zinc finger are important for activation of the nitric oxide‐inducible transcription factor Fzf1 in the yeast Saccharomyces cerevisiae
Authors: Nasuno Ryo , Yoshioka Natsuko , Yoshikawa Yuki , Takagi Hiroshi 
Published: July 2021

AbstractNitric oxide (NO) is a ubiquitous signaling molecule in various organisms. In the yeast Saccharomyces cerevisiae, NO functions in both cell protection and cell death, depending on its concentration. Thus, it is important for yeast cells to strictly regulate NO concentration. The transcription factor Fzf1, containing five zinc fingers, is reportedly important for NO homeostasis by regulating the expression of the YHB1 gene, which encodes NO dioxygenase. However, the mechanism by which NO activates Fzf1 is still unclear. In this study, we showed that NO activated Fzf1 specifically at the protein level by RT‐qPCR and Western blotting. Our further transcriptional analyses indicated that cysteine residues in the fourth zinc finger (ZF4) are required for the NO‐responsive activation of Fzf1. Additionally, the present results suggest that ZF4 is important for the protein stability of Fzf1. From these results, we proposed possible mechanisms underlying Fzf1 activation.
Early response and safety of atezolizumab plus bevacizumab for unresectable hepatocellular carcinoma in patients who do not meet IMbrave150 eligibility criteria
Authors: Sho Takuya , Suda Goki , Ogawa Koji , Kimura Megumi , Kubo Akinori , Tokuchi Yoshimasa , Kitagataya Takashi , Maehara Osamu , Ohnishi Shunsuke , Shigesawa Taku , Nakamura Akihisa , Yamada Ren , Ohara Masatsugu , Kawagishi Naoki , Natsuizaka Mitsuteru , Nakai Masato , Morikawa Kenichi , Furuya Ken , Baba Masaru , Yamamoto Yoshiya , Suzuki Kazuharu , Izumi Takaaki , Meguro Takashi , Terashita Katsumi , Ito Jun , Miyagishima Takuto , Sakamoto Naoya 
Published: July 2021

AbstractAimA clinical trial (IMbrave150) indicated the efficacy and safety of atezolizumab plus bevacizumab for patients with unresectable hepatocellular carcinoma (HCC). In this study, we evaluated this therapeutic combination in a real‐world setting, with a focus on patients who did not meet the IMbrave150 eligibility criteria.MethodsIn this multicenter study, patients with unresectable HCC treated with atezolizumab plus bevacizumab between October 2020 and May 2021 were screened. In patients who did not meet IMbrave150 eligibility criteria, treatment responses and safety at 6 and 12 weeks were evaluated.ResultsAtezolizumab plus bevacizumab was initiated in 64 patients, including 46 patients (71.9%) who did not meet IMbrave150 eligibility criteria. Most of these patients had a history of systemic therapy (44/46). The objective response rate and disease control rate observed using Response Evaluation Criteria in Solid Tumors 1.1 were 5.2% and 82.8% at 6 weeks and 10.0% and 84.0% at 12 weeks, respectively; these rates were similar between patients who met and did not meet the IMbrave150 criteria. Ten patients experienced progressive disease (PD) at 6 weeks. Portal vein tumor thrombosis was significantly associated with PD (p = 0.039); none of the 15 patients with hepatitis B virus‐related HCC experienced PD (p = 0.050). The most common adverse events of grade 3 or higher were aspartate aminotransferase elevation (n = 8, 13.8%) and the safety profile was similar between patients who met and did not meet the IMbrave150 criteria.ConclusionMost patients treated with atezolizumab plus bevacizumab did not meet the IMbrave150 criteria; however, the combination therapy showed good safety and efficacy at the early treatment phase.
Digital art history in 2021
Authors: Brey Alexander 
Published: July 2021

AbstractThe past decade has seen tremendous growth and innovation in the use of digital resources, methods, and tools in the history of art and architecture. While digital art history is less developed than text‐based disciplines, the emergence of new digital standards for visual and spatial data, and advances in computer vision are poised to revolutionize the field. This article provides a survey of recent developments in digital art history from the perspective of European and North American publications and conferences. I discuss the digitization of visual, spatial, and textual resources by museums, research centers, and individual researchers. Researchers have developed a variety of tools for digitally analyzing art and architecture, which can replicate or challenge traditional methods of formal, iconographic, and socio‐historical analysis. Trends in published research indicate uneven growth in the theoretical sophistication of digital art history scholarship. While digital methods are quickly moving into the training of art history professionals and students, digital art history communities in museums, research institutes, and universities remain somewhat fragmented. I conclude with a reflection on critiques of digital art history, several of which have not been fully addressed in recent scholarship.
Age class of alien tree stands retained for mammal protection have differential effects on flower‐visiting insect assemblages
Authors: Adedoja Opeyemi , Kehinde Temitope , Samways Michael J. 
Published: July 2021

Abstract
Limited sunlight reduces plant productivity and foraging activities of pollinators, such as when alien trees shade out native flowering plants. The conservation management response is to remove the impoverishing effect of the alien tree canopy. However, alien trees can provide benefit for certain species when they provide significant scarce resources. We assess how flower‐visiting insects respond to shading from young, small‐sized, open canopy vs. mature, tall, closed‐canopy alien pine trees retained specifically as refuges for certain rare mammals.
We sampled flower–visitor species diversity and interactions at various distances from pine stands of both sizes in a matrix of low sclerophyllous natural vegetation. We sampled flower–visitors using coloured pan traps and estimated flower–visitor interactions and flower diversity.
Reduction in percentage light reaching the understorey significantly reduced flower abundance, with zero flowers in tall pine understorey. Flower–visitor species composition differed across sampling locations with increasing distance from tall pine understorey. Although pine tree size led to a decline in flower–visitor interaction frequency and network specialisation in all pine tree stands, some bee species that are mostly tree nesters, were observed in unique interactions in association with tall pines only.
We show that alien pines, especially tall trees, have an impoverishing effect on flowering plants and flower–visitors. However, these trees also confer benefit to specialised groups such as tree‐nesting bees. While active alien pine removal is encouraged where the trees are actively invading, maintaining well‐contained small stands is of value for two different taxa of conservation concern.
Survival and prognostic factors of managing cracked teeth with reversible pulpitis: A 1‐ to 4‐year prospective cohort study
Authors: Lee Junghoon , Kim Sunil , Kim Euiseong , Kim Kyung‐Ho , Kim Seong Taek , Jeong Choi Yoon 
Published: July 2021

AbstractAimThis prospective clinical study evaluated the clinical performance of managing cracked teeth with reversible pulpitis through a combination of internal and external splinting and investigated factors that can affect pulp survival after splinting.MethodologyThirty‐four teeth diagnosed with cracks and reversible pulpitis were enrolled and treated with bidirectional crack splinting: 1) immediate splinting with a stainless‐steel band, 2) internal splinting with crack line removal and resin filling and 3) external splinting with a temporary crown followed by final crown placement. If the symptoms remained/recurred, root canal treatment was performed. Patients were followed up at 3, 6 and 12 months, then annually thereafter. Kaplan–Meier survival analysis to calculate the survival of the treated teeth and Cox univariate proportional hazards regression model to investigate prognostic factors were performed.ResultsTwenty‐nine (97%) teeth were followed up for up to 4 years. The pulp survival rate was 72% after banding and 91% after final crown cementation. No tooth was extracted (100% tooth survival rate). In the univariate Cox proportional hazard test, pain on percussion was the only statistically significant factor (hazard ratio = 11.77). Teeth with pain on percussion at the first visit had a pulp survival rate of 46% during the follow‐up period. In comparison, their counterparts without pain had a 94% pulp survival rate.ConclusionsBidirectional splinting successfully managed cracked teeth with reversible pulpitis. Pain on percussion (mechanical allodynia) may be an important factor in deciding whether to attempt root canal treatment on symptomatic cracked teeth. A step‐by‐step approach with bidirectional crack splinting should be encouraged for a cracked tooth with a vital pulp without mechanical allodynia rather than pre‐emptive root canal treatment.
The forms of financial literacy overconfidence and their role in financial well‐being
Authors: Vörös Zsófia , Szabó Zoltán , Kehl Dániel , Kovács Olivér Béla , Papp Tamás , Schepp Zoltán 
Published: July 2021

AbstractOverconfidence in financial literacy (FL) is defined and assessed in various ways, and results regarding the effects of FL overconfidence on financial well‐being are inconsistent. Therefore, this study aims to develop our understanding of the processes by which overconfidence in FL influences the financial well‐being of consumers; that is to separately examine the effects of the different forms of FL overconfidence on financial well‐being. In order to map the associations between FL, the forms of FL overconfidence, and financial well‐being, the data of 506 randomly selected Hungarian test‐takers were collected by a self‐report questionnaire. According to the results, FL and its overestimation (OE) are positively linked to households' financial outcomes. Hence, perceived FL is a better predictor of financial well‐being than actual FL skills. Moreover, the results add to the existing body of literature by showing that the effects of the different forms of overconfidence are divergent: overprecision and OE may be damaging. Thus, the paper provides evidence that FL overconfidence is a multifaceted construct, and its different forms affect financial well‐being differently.
Caregivers’ experiences of contributing to patients’ self‐care in Chronic Obstructive Pulmonary Disease: A thematic synthesis of qualitative studies
Authors: Matarese Maria , Pendoni Roberta , Piredda Michela , De Marinis Maria Grazia 
Published: July 2021

AbstractAimTo identify, analyze and synthesize qualitative studies on caregivers’ experiences of contributions to the self‐care of patients with Chronic Obstructive Pulmonary Disease (COPD).BackgroundCOPD patients perform daily self‐care behaviours to manage the disease. With aging and disease progression, patients need to rely on the contributions of informal caregivers, usually family members, for disease management. Caregivers’ normal or habitual contributions to patients’ self‐care have not yet been completely investigated.DesignThematic synthesis of qualitative studies.Data sourcesCINAHL, EMBASE, PubMed, PsycINFO, Web of Science, Scopus, Emcare and OpenGrey databases were searched from inception to September 2020. The search was restricted to English‐language papers.Review methodsStudies were critically appraised using the Critical Appraisal Skills Programme checklist. The initial line‐by‐line codes were aggregated into descriptive themes from which analytical themes were derived.ResultsFifteen papers from nine countries, published 2009–2020, were included. Six analytical themes encompassing 22 descriptive themes were identified and grouped in two overarching themes describing caregivers’ experiences of contributions to patients’ self‐care during the stable and exacerbation phases of COPD. In the stable phases, caregivers contribute through maintaining disease stability, promoting healthy behaviours, fostering normal life and helping perform daily activities. During exacerbations, caregivers contribute through assessing, monitoring and managing symptoms in collaboration with patients or autonomously. They contribute by performing actions, motivating patients, organizing care, sensing variations in symptoms, acquiring knowledge and educating patients, making decisions, communicating and collaborating with healthcare providers and patients and advocating for patients.ConclusionThis thematic synthesis enlarges knowledge of caregivers’ contributions to patients’ self‐care in COPD, detailing the ways by which caregivers provide care to patients.ImpactContributing daily to the self‐care of a family member with COPD is a complex experience. Nurses need to acknowledge the importance of caregivers’ contributions to patient disease management and develop effective educational interventions to support them.
People with intellectual disabilities living in care facilities engaging in virtual social contact: A systematic review of the feasibility and effects on well‐being
Authors: Bakkum Lianne , Schuengel Carlo , Sterkenburg Paula S. , Frielink Noud , Embregts Petri J. C. M. , de Schipper Johanna Clasien , ten Brug Annet , Tharner Anne 
Published: July 2021

AbstractBackgroundDuring the initial phase of the COVID‐19 pandemic, many people with disabilities living in home care facilities could not receive visitors. The use of virtual social contact has been recommended by health authorities. This systematic review examined the scientific evidence of the use and feasibility of information and communication technology (ICT) for social contact by people with intellectual disabilities living in care facilities, and potential effects on well‐being.MethodsFive databases were searched using traditional systematic screening and machine‐learning supported screening. Findings are presented in a narrative synthesis using thematic analysis.ResultsNine studies were included. We described three themes: means of ICT used for social contact; effects on well‐being; and benefits, barriers, and preconditions.ConclusionsEngaging in virtual social contact may be feasible for people with severe to mild intellectual disabilities, but there is little concrete evidence that this can be used as an alternative for in‐person contact.
Safety and feasibility of left bundle branch area pacing following valvular interventions: Multicenter study
Authors: Gul Enes Elvin , Kabadi Rajiv A. , Padala Santosh K. , Sanchez Somonte Paula , Kron Jordana , Shepard Richard K. , Koneru Jayanthi N. , Kalahasty Gautham , Terricabras Maria , Tsang Bernice , Khaykin Yaariv , Wulffhart Zaev , Pantano Alfredo , Ellenbogen Kenneth A. , Verma Atul 
Published: July 2021

AbstractObjectivesTo evaluate the safety and feasibility of left bundle branch area pacing (LBBAP) in patients with valvular interventions.MethodsEighty‐four patients were included in this study. All patients underwent recent surgical or percutaneous valvular interventions. LBBAP was attempted in all patients. Implant success rates, peri‐ and postprocedure electrocardiogram, pacing parameters, and complications were assessed at implant, and during follow‐up.ResultsLBBAP implantation was successful in 80/84 (95%) patients. Mean age was 74.1 ± 13.8 years and 56% patients were male. Prior valvular replacements included: percutaneous aortic (26), surgical aortic (36), combined surgical aortic plus mitral (6), MVR (10), tricuspid (1), and pulmonic (1). Average LVEF was 52.6 ± 11%. Majority of patients underwent LBBAP due to atrioventricular block (76%) and sinus node disease (13%). Total procedure duration was 74.1 ± 12.5 min and fluoroscopic duration was 9.7 ± 6.8 min. Pacing parameters were stable during follow‐up period of 10.0 ± 6.3 months. Pacing QRS duration was significantly narrower than baseline QRS duration (131.5 ± 31.4 ms vs. 114.3 ± 13.7 ms, p < .001, respectively). No acute complications were observed. Mean follow‐up was 10.0 ± 6.3 months (median: 8.4 months, min: 1 and max: 24 months). During follow‐up, there were three device infections and two patients had loss of LBBA capture within 1 month of implant.ConclusionsLBBAP is a feasible and safe pacing modality in patients with prior interventions for valvular heart disease.