bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced cytotoxic effects of Clinacanthus nutans and doxorubicin in combination toward breast cancer cell lines
Authors: Widjaja Sry Suryani , Rusdiana  , Ichwan M. 
Published: April 2021

ABSTRACT
Breast cancer is one of the most common cancers with a relatively high mortality rate. Despite the advancement of its medical treatments, many patients are still seeking complementary alternative medicines, namely Clinacanthus nutans which is found mainly in South-East Asian countries. We aim to find the antioxidant properties and cytotoxic activity of the plant extract toward breast cancer cell lines Michigan Cancer Foundation-7 (MCF7) and T47D individually and in combination with doxorubicin. Extractions of C. nutans with ethanol, n-hexane, and ethyl acetate were done using rotatory vacuum evaporators with the reflux method. Screening of biochemical properties was conducted. Antioxidant activity was measured toward α, α-diphenyl-β-picrylhydrazyl (DPPH) with IC50 scores were shown to be highest in ethyl acetate extract. Cytotoxic effects of all three extracts were shown to be low in both MCF7 and T47D cells. However, combinations of 125 μg/ml n-hexane extract of C. nutans, and 0.1 μg/ml doxorubicin in T47D cancer cells showed further proliferation reduction compared to the single administration. The results suggested possible synergisms of the treatment combination.
Egg white-induced inflammation models
Authors: Barung Elisabeth Natalia , Dumanauw Jovie Mien , Duri Meilany Feronika , Kalonio Donald Emilio 
Published: April 2021

ABSTRACT
The egg white was used to induce rat paw inflammation, with inadequate references to explain its mechanism. It's contained protein was identified as an allergen was suspected to trigger an inflammatory reaction. This research was aimed to evaluate the use of egg white as an inflammatory inductor in inflammation animal models through edema profile and histological change. Male Wistar rats were divided into three groups, which were given λ-carrageenan, fresh takes of the hen's egg white, and sterile saline solution. Edema was induced by subcutaneous injection of 0.1 ml of λ-carrageenan (1%), egg white, and sterile saline solution as the control in the hind paw of rats. Paw volume was measured before and then at 1, 2, 3, 4, 5, 6, and 24 h after the inductor injection. Paw tissue was taken for evaluation of rats’ paw histological change. The data were analyzed by one-way ANOVA followed by LSD test. The results of the study showed that the egg white could induce rat paw inflammation. Edema formation began in the 1st h and reached the peaks in the 2nd h after the subcutaneous injection of egg white. A number of leukocyte cells were also found in the inflamed paw tissues. Egg white was potential as an edema inductor for animal models of inflammation for the evaluation of new drugs or natural product with anti-inflammation activity.
Structure-based virtual screening of bioactive compounds from Indonesian medical plants against severe acute respiratory syndrome coronavirus-2
Authors: Gani Maria Apriliani , Nurhan Ahmad Dzulfikri , Maulana Saipul , Siswodihardjo Siswandono , Shinta Dewi Wara , Khotib Junaidi 
Published: April 2021

ABSTRACT
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a virus that causes the infectious disease coronavirus disease-2019. Currently, there is no effective drug for the prevention and treatment of this virus. This study aimed to identify secondary metabolites that potentially inhibit the key proteins of SARS-CoV-2. This was an in silico molecular docking study of several secondary metabolites of Indonesian herbal plant compounds and other metabolites with antiviral testing history. Virtual screening using AutoDock Vina of 216 Lipinski rule-compliant plant metabolites was performed on 3C-like protease (3CLpro), RNA-dependent RNA polymerase (RdRp), and spike glycoprotein. Ligand preparation was performed using JChem and Schrödinger's software, and virtual protein elucidation was performed using AutoDockTools version 1.5.6. Virtual screening identified several RdRp, spike, and 3CLpro inhibitors. Justicidin D had binding affinities of −8.7, −8.1, and −7.6 kcal mol−1 on RdRp, 3CLpro, and spike, respectively. 10-methoxycamptothecin had binding affinities of −8.5 and −8.2 kcal mol−1 on RdRp and spike, respectively. Inoxanthone had binding affinities of −8.3 and −8.1 kcal mol−1 on RdRp and spike, respectively, while binding affinities of caribine were −9.0 and −7.5 mol−1 on 3CLpro and spike, respectively. Secondary metabolites of compounds from several plants were identified as potential agents for SARS-CoV-2 therapy.
Empirical analysis of extreme weather conditions and aviation safety in Nigeria
Authors: Akanni C.O. , Hassan A.M. , Osuji T.C. 
Published: April 2021

The frequency of delay, diversion and outright cancellation occasioned by poor weather has affected the Nigerian aviation industry and serious safety implication.This study therefore examines the influence of weather conditions on aviation safety in Nigeria. Secondary data basically from Nigeria Meteorological Agency such as information on thunderstorm, fog occurrence and rainfall from 2004 to 2013 and data obtained from Federal Airport Authority of Nigeria on air accident induced by extreme weather within the same period were analysed using Multiple Regression Analysis. Results show that low visibility as a result of fog occurrence causes four (4) air traffic accidents more than other weather conditions and that Lagos experienced two (2) air accidents more than other airports during the period under study. So also the value of R2 shows a value of 77.8% which implies that there is variation in the dependent variable (Airport Operation) which can be predicted by independent variables (Weather conditions). The F-statistic value of 62.892 is also found to be statistically significant at 5% (p<0.05) which shows that weather condition has significant influence on aviation safety. Baseline studies on flight operation, government intervention in aviation industry, maintenance culture were recommended.Keywords: Fog, Thunderstorm, Rainfall, Safety, Accident
Pengaruh Pertumbuhan Ekonomi, Upah Minimum, dan Tingkat Pengangguran terhadap Kesejahteraan Masyarakat di Jawa Timur Tahun 2014-2018
Authors: Shavira Shella Okky , Balafif Mohammad , Imamah Nurul 
Published: April 2021

Penelitian ini bertujuan untuk mengetahui pengaruh pertumbuhan ekonomi, upah minimum, dan tingkat pengangguran terhadap kesejahteraan masyarakat di Jawa Timur tahun 2014-2018. Data yang digunakan adalah data sekunder dengan cross section termasuk data satu tahun di setiap kabupaten di Provinsi Jawa Timur tahun 2014-2018. Data sekunder ini bersumber dari badan pusat statistik Jawa Timur. Metode analisis data yang digunakan dalam penelitian ini adalah metode kuantitatif dengan analisis data dan analisis regresi linier menggunakan SPSS. Di dalam model variabel independen yang digunakan adalah pertumbuhan ekonomi, upah minimum, dan tingkat pengangguran. Sementara variabel dependen adalah indeks pembangunan manusia. Hasilnya menunjukkan pertama, pertumbuhan ekonomi berpengaruh positif dan signifikan terhadap kesejahteraan masyarakat di Provinsi Jawa Timur tahun 2014-2018. Untuk variabel pertumbuhan ekonomi yang diperoleh thitung > ttabel demikian H0 ditolak Ha diterima. Kedua, upah minimum berpengaruh positif dan signifikan terhadap kesejahteraan masyarakat di Provinsi Jawa Timur tahun 2014-2018. Untuk variabel upah minimum yang diperoleh thitung > ttabel demikian H0 ditolak Ha diterima. Ketiga, tingkat pengangguran berpengaruh negatif dan signifikan terhadap kesejahteraan masyarakat di Provinsi Jawa Timur tahun 2014-2018. Untuk variabel tingkat pengangguran yang diperoleh thitung < ttabel demikian H0 diterima Ha ditolak.
РАСШИРЕНИЕ АССОРТИМЕНТА
КОНДИТЕРСКИХ ИЗДЕЛИЙ ОБОГАЩЕННЫХ
РАСТИТЕЛЬНЫМИ КОМПОНЕНТАМИ
Authors: Голован Д.С. , Берсенева А. , Белова М.П. , Чернега О.П. 
Published: April 2021

В статье приведены результаты исследования, позволяющие расширить ассортимент
кондитерских изделий за счет добавления к фруктово-ягодным прослойкам овощных.
Овощные компоненты отличаются по органолептическим свойствам от фруктово-ягодных,
при этом и те, и другие содержат физиологически активные вещества. Обоснован выбор
ингредиентов рецептуры. Подобраны режимы тепловой обработки для более полного
сохранения физиологической активности растительных компонентов. Доказано, что
добавление конфи из облепихи и сладкого красного перца обеспечивает суточную
потребность в витамине С для взрослого человека на 16 %. Вносимая добавка из сладкого
красного перца дополнительно обогащает продукт ликопином. Приведена
органолептическая оценка готового кондитерского изделия. Подобран загуститель для
зеркальной глазури, не меняющий своих свойств после размораживания готового изделия.
ИСПОЛЬЗОВАНИЕ БИОЛОГИЧЕСКИХ ПРЕПАРАТОВ ДЛЯ
ПОВЫШЕНИЯ ПОСЕВНЫХ КАЧЕСТВ СЕМЯН АСТРАГАЛА
МОНГОЛЬСКОГО (ASTRAGALUS MONGHOLICUS BGE.)
Authors: Болтова Н.С. , Калинина Е.А. 
Published: April 2021

В статье представлены результаты исследования оценки эффективности
биологических препаратов при повышении посевных качеств семян астрагала монгольского.
Установлено, что изученные препараты Рибав-Экстра и Восток ЭМ-1 (ЭМ-био) в различных
концентрациях положительно влияют на прорастание и всхожестьсемян. При этом действие
препарата Восток ЭМ-1 в концентрации 2 мл/л воды оказалось несколько сильнее, чем
действие этого же препарата в концентрации 1 мл/л воды. Эффективность действие
Рибав-Экстра в концентрации 0,2 мл/л воды было больше, чем в концентрации 0,1 мл/л воды.
При сравнении двух эффективно действующих препаратов, более эффективным оказался
ЭМ-био (Восток ЭМ-1) в концентрации 2 мл/л воды – всхожесть в этом варианте составила
68 %. Исследования, направленные на повышение посевных качеств семян, являются
важным элементом в технологии возделывания лекарственных растений.
Світові тенденцій розвитку дистанційного навчання: системоутворюючі фактори системи дистанційного навчання у вищих військових навчальних закладах
Authors: Poltorak M. F. , Orda M. V. , Kozak N. D. , Levitska L. A. , Bielozorova O. V. 
Published: April 2021

Вступ. Останніми роками в Україні питання дистанційного навчання перебуває у процесі постійного наукового обговорення і є новою формою навчання, включаючи військову національну освіту в Україні.
Метою статті є аналіз факторів, що суттєво впливають на ефективність системи дистанційного навчання Збройних Сил України, а також розуміння світових тенденцій розвитку систем дистанційного навчання як елементу електронного навчання.
Матеріали та методи. Аналіз, порівняння та систематизація наукових джерел.
Результати. Проведений аналіз питань, що стосуються світових тенденцій розвитку систем дистанційного навчання як елементу електронного навчання. Розглянуто фактори, що суттєво впливають на ефективність системи дистанційного навчання Збройних Сил України. Розкрито сутність дистанційного навчання у вищих військових навчальних закладах (ВВНЗ) та військових навчальних підрозділах закладів вищої освіти (ВНП ЗВО) як особливої форми цілеспрямованого процесу оволодіння знаннями, вміннями та навичками військовими спеціалістами. Визначено основну особливість дистанційного навчання у вищих навчальних закладах та військових навчальних підрозділах закладів вищої освіти (екстериторіальність - необов’язкове перебування слухачів (курсантів) у військовому навчальному закладі; відсутність заперечення щодо участі науково-педагогічних працівників у ході проведення освітнього процесу).
Висновки. Впровадження технологій дистанційного навчання в систему підготовки Збройних Сил України покликане забезпечити появу нових можливостей для оновлення змісту викладання та методики викладання дисциплін та розповсюдження знань, розширення доступу до освітніх ресурсів. Отже, це потребує подальших досліджень щодо розвитку дистанційного навчання та його впровадження, зокрема, у національній системі військової освіти.
PENERAPAN GAME CORRONA UNTUK MENINGKATKAN HASIL BELAJAR PADA MATERI PENGENALAN PERALATAN DASAR LABORATORIUM KIMIA DI KELAS X SMKN 1 MOJOANYAR
Authors: Hidayati Sri 
Published: April 2021

Materi pengenalan peralatan dasar laboratorium kimia merupakan salah satu materi untuk mata pelajaran Teknik Dasar Pekerjaan Laboratorium Kimia (TDPLK). Materi ini diberikan kepada peserta didik di jenjang SMK kelas X untuk kompetensi keahlian kimia analisis. Pada materi ini, peserta didik dituntut untuk mengenal nama alat-alat yang terdapat di laboratorium kimia, dari alat gelas, alat non gelas serta alat penunjang lainnya. Selain mengenal nama alat, mereka juga dituntut untuk mengetahui fungsi setiap alat sehingga mereka akan lebih mudah melakukan dalam melakukan praktikum lanjutan di laboratorium kimia. Tuntutan ini menjadi lebih sulit karena sebagian besar alat yang ada di laboratorium merupakan alat yang baru mereka kenal. Sehingga diperlukan media menarik untuk mempermudah pengenalan alat dasar laboratorium kimia yaitu berupa game CORrONA-COcokno gambaR kaRO NAma (jawa-red). Jenis penelitian ini merupakan penelitian tindakan kelas (PTK) dengan dua siklus, masing-masing siklus terdiri dari perencanaan, pelaksanaan, pengamatan, dan refleksi. Setiap siklus dilakukan sebanyak 1 kali pertemuan (3x45 menit). Subyek penelitian ini adalah peserta didik kelas X KA 1 SMKN 1 Mojoanyar tahun pelajaran 2019/2020. Data hasil tes dianalisis secara deskriptif kuantitatif-kualitatif. Hasil penelitian menunjukkan bahwa rata-rata nilai kelas pada siklus I sebesar 70 dengan 73% peserta didik mencapai KKM, sedangkan pada siklus II rata-rata nilai kelas meningkat sebesar 80 dengan 88% peserta didik mencapai KKM. Peningkatan hasil belajar juga terjadi untuk hasil belajar afektif maupun psikomotor. Sehingga dapat disimpulkan bahwa pembelajaran dengan game CORRONA mampu meningkatkan hasil belajar peserta didik.
Pengelolaan Biaya Pendidikan: Kajian Studi Pustaka
Authors: Hasibuan Lias , Anwar Us Kasful , Zas Pendi Hamdi 
Published: April 2021

Perekonomian Indonesia cenderung mengarah pada krisis multidime nsional yang terus membelengg negara kita. Nampaknya, sampai saat ini belum ada tanda-tanda bangsa kita akan terbebas dari krisis tersebut. Hal tersebut berdampak pada kehidupan masyarakat, khususnya masyarakat yang kurang mampu semakin berat beban hidupnya, terutama bagi golongan masyarakat yang status ekonominya kurang beruntung. Hal ini dapat dicermati dari segala jenis kebutuhan hidup yang semakin tid ak terjangka. Masalah pendidikan misalnya, merupakan salah satu masalah bangsa yang belum dapat ditemukan solusinya secara tuntas. Jika kita mencermati dan ikuti perkembangan pendidikan khususnya dalam hal biaya pendidikan sampai saat ini, biaya tersebut dirasakan semakin mahal.
Terlebih lagi, dari kalangan kurang mampu semakin tidak menentu kondisi perekonomiannya dari hari ke hari. Apalagi bagi masyarakat yang tidak memiliki penghasilan tetap dikarenakan pemu-tusan hubungan kerja (PHK) atau disebakan oleh karena hal yang lainnya. Mahalnya biaya pendidikan tidak hanya terjadi di sekolah atau perguruan tinggi negeri maupun swasta. Di tingkat pendidikan dasar misalnya, sekalipun Pemerintah telah memberi dana bantuan operasional sekolah (BOS) SD dan SMP negeri, namun dianggap oleh sebagian besar masyarakat menengah ke bawah masih belum mencukupi untuk memenuhi biaya pendidikan, terutama biaya operasional pokok yang harus ditanggung oleh orangtua/wali peserta didik.
DESENVOLVIMENTO TERRITORIAL E SOCIOBIODIVERSIDADE: CONTORNOS TEÓRICOS-CONCEITUAIS E DIRETRIZES METODOLÓGICAS DE UM PROJETO GUARDA-CHUVA
Authors: Marques Ana Carolina de Oliveira , Alves Souza Josy Dayanny 
Published: April 2021

O ano de 2016 marca o início da execução do projeto guarda-chuva intitulado: “Desenvolvimento Territorial e Sociobiodiversidade: perspectivas para o Mundo do Cerrado[1]”. Sob a coordenação geral do professor Eguimar Felício Chaveiro, da Universidade Federal de Goiás, uma equipe de pesquisadores de diversas universidades brasileiras tem promovido eventos científicos, missões de pesquisa internacionais e trabalhos de campo, cujos resultados são divulgados por meio de artigos em periódicos, livro, relatórios de estágio pós-doutoral, anais de eventos, além de três teses de doutorado em construção. Este texto cumpre o propósito de divulgação científica das ações e resultados preliminares do projeto, sobretudo os avanços teóricos na definição do conceito de “sociobiodiversidade”. As entrevistas semiestruturadas com os coordenadores – geral e associados – e um dos estagiários de pós-doutorado, possibilitaram a construção de um mapa conceitual da sociobiodiverdade, acompanhado de diretrizes metodológicas apreendidas a partir das experiências de pesquisa mobilizadas no projeto.

[1] Projeto aprovado no âmbito do Programa de Apoio à Pós-Graduação e à Pesquisa Científica e Tecnológica em Desenvolvimento Socioeconômico no Brasil – PGPSE/CAPES.
Kay Fisker
Authors: Søberg Martin 
Published: April 2021

Kay Fisker (1893-1965) is considered one of the most influential Danish architects of the twentieth century, and yet there has existed until now no in-depth English-language study of his works and writing.
Published as part of the Bloomsbury Studies in Modern Architecture series, which brings to light the work of significant yet overlooked modernist architects, this book examines Fisker’s key projects – from his early railway stations and innovative housing projects to the Danish Academy in Rome – and analyses his work as a historian and writer.
Fisker’s output is closely associated with the functional tradition, a hybridization of international modernism and regional architectural typologies, and this book shows how his architectural poetics can be understood as an amalgamation of an ideal order with the contingent conditions of landscapes and urban sites. Hybridization is not only a valuable notion for understanding Fisker, the book argues, it can also be applied to an understanding of modernist architecture as a whole, with its various expressions, agendas and tensions both regionally and internationally.
Beckett’s Laboratory
Authors: Wakeling Corey 
Published: April 2021

Offering fresh studies of Samuel Beckett in pre-production, in rehearsal, as an innovator of the script form, and as a speculative director and designer, Beckett’s Laboratory reconsiders Beckett’s stringent approach to stage direction through the lens of the laboratory and reveals his experimentalism with stage representation and composition. Wakeling argues that acknowledging Beckett’s experimental processes, from their composition to their reception, is crucial to understanding the innovative representations of humanity that emerged at different stages in Beckett’s practice.
Repositioning Beckett’s performance oeuvre in relation to philosophy, Wakeling draws upon post-dramatic, symbolist, materialist and post-structural understandings of theatre performance to reappraise Beckett’s plays as a composition for performance. The philosophical underpinnings of Beckett’s practices are explored through an eclectic mix of familiar and unexplored contemporary theatre productions and films of Beckett’s works, including Not I, Nacht und Träume, Happy Days, Footfalls and Catastrophe.
Beckett’s Laboratory is a provocative examination of Beckett’s experimentalism with the human spectacle and his playful reliance upon the interpretative powers of the actors and audience.
Fashioning Spain
Authors: Fernández de Alba Francisco , Garcés Marcela T. 
Published: April 2021

Fashioning Spain is a cultural history of Spanish fashion in the 20th and 21st centuries, a period of significant social, political, and economic upheaval. As Spain moved from dictatorship to democracy and, most recently, to the digital age, fashion has experienced seismic shifts. The chapters in this collection reveal how women empowered themselves through fashion choices, detail Balenciaga’s international stardom, present female photographers challenging gender roles under Franco’s rule, and uncover the politicization of the mantilla. In the visual culture of Spanish fashion, tradition and modernity coexist and compete, reflecting society’s changing affects.
Using a range of case studies and approaches, this collection explores fashion in films, comics from la Movida, Rosalía’s music videos, and both brick-and-mortar and virtual museums. It demonstrates that fashion is ripe with historical meaning, and offers unique insights into the many facets of Spanish cultural life.
Screening Queer Memory
Authors: Horvat Anamarija 
Published: April 2021

In Screening Queer Memory, Anamarija Horvat examines how LGBTQ history has been represented on-screen, and interrogates the specificity of queer memory. She poses several questions: How are the pasts of LGBTQ people and communities visualised and commemorated on screen? How do these representations comment on the influence of film and television on the construction of queer memory? How do they present the passage of memory from one generation of LGBTQ people to another? Finally, which narratives of the queer past, particularly of the activist past, are being commemorated, and which obscured?
Horvat exemplifies how contemporary British and American cinema and television have commented on the specificity of queer memory - how they have reflected aspects of its construction, as well as participated in its creation. In doing so, she adds to an under-examined area of queer film and television research which has privileged concepts of nostalgia, history, temporality and the archive over memory. Films and television shows explored include Cheryl Dunye’s The Watermelon Woman (1996), Todd Haynes’ Velvet Goldmine (1998), Jill Soloway’s Transparent (2014-2019), Matthew Warchus’ Pride (2014) and Tom Rob Smith’s London Spy (2015).
Allegro non troppo
Authors: Bellano Marco 
Published: April 2021

“A film that will let you see the music and listen to drawings; in a word, a film full of Fantasia!” Bruno Bozzetto’s Allegro non Troppo tips its hand right away: it is an unabashed, yet full of admiration, retake on Walt Disney’s 1940 “concert feature”. The obvious nod to that model fuels many tongue-in-cheek jokes in the film; however, Allegro non Troppo soon departs from mere parody, and becomes a showcase for the multifaceted aesthetics of Italian animation in 1976, as well as a witty social satire and a powerful rethinking of the music-image relationship in cinema.
Marco Bellano reconstructs the history of the production of Allegro non Troppo, on the basis of an original research developed with the contribution of Bozzetto himself; it also presents an audiovisual analysis of the work, as to reassess the international relevance of Bozzetto’s achievements by giving insight into the director’s creative process.
This book is available as open access through the Bloomsbury Open Access programme and is available on www.bloomsburycollections.com