bluuebunny/crossref_metadata_2025_split huggingface dataset:
Becoming the State-Funded Madrasah or Retaining Autonomy: The Case of Two Madrasahs in Kelantan
Authors: Latief Hilman , Robani Anidah , Kamarudin Mohd Fauzi , Rozikan Rozikan 
Published: July 2021

<p>Malaysia witnessed the rise of Islamic education more than a century ago, partly evidenced by the establishment of traditional Islamic education institutions called pondok or madrasah. Starting in the nineteenth century, Islamic pondok schools spread in Malaysia, founded by ‘ulama (Islamic scholars) who gained financial support from the community. As time went by, many pondok, previously supported by civil society, began to face financial difficulties because of the changing political landscape, economic situation, the death of their founders, and changes in government policy. This paper investigates the experiences of two madrasahs in the state of Kelantan in Malaysia and the strategies they have adopted to resolve their financial issues. This paper argues decisions and strategies regarding financing were influenced by several factors, including the degree of attachment felt by the current asatidz (teachers) to the history of their pondok, their desire to preserve the legacy of the madrasah founder, and the level of economic pressure they experienced. The primary choice was between relinquishing ownership to the state by becoming a state (funded) school or remaining a self-governed school with limited access to state funds. </p>
Quantification of Potentially Toxic Elements in Degraded Mining Soils and Medicinal Plants: A Case Study of Indus Kohistan Region Northern Pakistan
Authors: sardar Waseem , Rahman Aziz Ur , nawab javed , Khan Sardar , Ali Abid , Rahman Zia Ur , Baig Shams Ali , Khan Muhammad Qayash 
Published: July 2021

Abstract
In recent years, a series of environmental and ecological problems have occurred due to enhanced anthropogenic disturbances for precious minerals mining. Traditional medicines have become an important pillar in national homeopathic treatment system especially in mountainous environment of developing countries. The current study investigates the level of potentially toxic elements ( PTEs ) contamination in degraded mining soil and medicinal plants along the mafic-ultramafic rocks in the Kohistan region. Soil samples and medicinal plant species were collected from the degraded mining area and were screened for PTEs (Pb, Cr, Ni, Mn, Zn, and Cd) using atomic absorption spectrometry. Various pollution indices were used for PTEs such as contamination factor (CF), pollution load index (PLI) and translocation factor (TF) in degraded mining soil and medicinal plants. The mean concentration of PTEs found in soil were in order of Mn>Ni>Cr >Pb>Zn>Cd, while in medicinal plants were Pb>Cr>Mn>Ni>Zn>Cd. Highest bioaccumulation was observed in Ajuga bracteosa (Cr=349 mg kg –1 ), Phlomis bracteosa (Pb=335 mg kg –1 ), Chenopodium ambrosioides (Mn = 304.3 mg kg –1 ), Isatis costata (Ni=169 mg kg –1 ), Ajuga parviflora (Zn = 38.4 mg kg –1 ) and Salvia moorcoftiana (Cd=11 mg kg –1 ). Furthermore, the concentrations of PTEs were significantly higher ( p <0.001) in degraded mining soil and medicinal plants than the reference site, which may be attributed to the mining and open dumping of mining wastes. The present study revealed that chromite mining and open dumping of mining wastes can cause serious environmental problem in the study area. Furthermore, medicinal plants grown in degraded mining soil may pose risk to the local inhabitants as most of the people consume these plants for various health problems.
Prenatal Glucocorticoid Administration Accelerates Maturation in the Hepatocytes of Fetal Rats
Authors: Kobayashi Tsukasa , Takeba Yuko , Ohta Yuki , Ootaki Masanori , Kida Keisuke , Watanabe Minoru , Iiri Taroh , Matsumoto Naoki 
Published: July 2021

Abstract
Prenatal glucocorticoid (GC) is clinically administered to pregnant women at risk of preterm birth for maturation of the cardiopulmonary function. Preterm and low birth weight infants often experience liver dysfunction after birth because the liver is immature. However, the effects of prenatal GC administration on the liver remain unclear. We aimed to investigate the effects of prenatal GC administration regarding maturity of the liver in preterm rats. Dexamethasone (DEX) was administered to pregnant Wistar rats on gestational day 17 and 19 before cesarean section. Real time polymerase chain reaction (RT-PCR) was then used to analyze the mRNA levels (albumin, HNF4α, HGF, Thy-1, cyclin B, and CDK1) in the liver samples. Immunohistochemical staining and enzyme-linked immunosorbent assay (ELISA) were used to analyze protein production. Hepatocyte size enlarged because of growth and administration of prenatal DEX. Albumin, HNF4α, and hepatocyte growth factor (HGF) increased secondary to growth and administration of prenatal DEX. Cell cycle markers, cyclin B, and CDK1 gradually decreased during growth and by administration of DEX. These results suggest that prenatal GC administration achieves hepatocyte maturation via expression of HNF4α and HGF in premature fetuses.
Soft sediment deformation features in Dauki Fault region: Evidence of paleoearthquakes, Shillong Plateau, NE India
Authors: Lakshmi B.V , Gawali Praveen B. 
Published: July 2021

Abstract
The northeastern region (NER) of India has a number of complex regional geological structures, out of which the Dauki fault (DF) is a prominent one. The E-W trending reverse DF, which is referred to go through the southern margin of Shillong Plateau (SP), have played major role in the regional deformation of the adjoining areas and was believed to be active during the Late Quaternary time. Previous paleoseismological studies conducted on the eastern and western part of the DF, Bangladesh, revealed that the fault ruptured in AD 849–920 and AD 1548 respectively. However there were no studies on the DF from southern side of the SP, India. For the first time, from Indian side, soft sediment deformation structures (SSDS) are reported from five trenches in and around the DF zone, SP. Close to the Dauki village, five trenches in the eastern part of the DF, SP, show presence of micro faulting, sand dykes, disturbed strata, and water escape structures. The detailed investigation of SSDS indicates that the origin for deformation is seismic trigger. The 14C AMS dating of deformation structures generated coseismically by earthquakes suggest three seismic events occurred between 130 and 920 year BP, 5415 to 9140 year BP, and at about 4285 year BP. This study confirms that DF is indeed active, at least, since the mid-Holocene. More trenching and dating of seismically induced deformation features are needed to accurately calculate the recurrence interval of major earthquakes that can strike the fast-expanding urban areas in India and Bangladesh.
Depression, Hope and Social Support Among Older People With Cancer: A Comparison of Muslim Palestinian and Jewish Israeli Cancer Patients
Authors: Goldzweig Gil , Baider Lea , Jacobs Jeremy , Ghrayeb Ibtisam M , Sapir Eli , Rottenberg Yakir 
Published: July 2021

Abstract
ObjectivesStudies of depression in older Muslim Palestinians diagnosed with cancer are scarce. To gain insight into the psychological response and coping ability of this very large, globally distributed population, we collected data from older Muslim Palestinian people diagnosed with cancer concerning depression hope and perceived social support. Both hope and social support were selected because they can be manipulated through intervention and education, as shown in the geriatric literature. Data were compared to data collected from older Jewish Israeli people diagnosed with cancer. DesignThe study sample comprised 143 Muslim Palestinian and 110 Jewish Israeli people diagnosed with cancer, aged >=65. All participants were either in treatment for active disease or within six months of such treatment. Self-administered measures included depression (the Five-Item Geriatric Depression Scale), perceived social support (Cancer Perceived Agents of Social Support Questionnaire) and hope (Snyder’s Adult Hope Scale). ResultsHope and depression were both found to be significantly higher among the Muslim Palestinian patients than in the Jewish Israeli participants. In both samples, higher levels of hope were associated with lower levels of depression, with this correlation stronger in the Jewish Israeli group. ConclusionTo improve the psychological wellbeing of patients, healthcare providers must exercise cultural sensitivity in their interactions, respecting the perspectives of both the patients and their families. Incorporating the concept of hope into the therapeutic dialogue and language may improve psychological wellbeing and synchronize the needs and expectations of patients, caregivers, and healthcare professionals, resulting in more equitable, effective and value-oriented care.
Transferring Cognitive Talent Across Domains: The Case of Finance
Authors: Rotaru Kristian , Kalev Petko S. , Yadav Nitin , Bossaerts Peter 
Published: July 2021

Abstract
We consider Theory of Mind, the ability to correctly predict the intentions of others. The skill requires abstraction from one’s own particular circumstances. Here, we posit that such abstraction can be transferred successfully to other, non-social contexts. We consider the disposition effect, which is a pervasive cognitive bias whereby investors, including professionals, improperly take their personal trading history into account when deciding on investments. We design an intervention policy whereby we attempt to transfer Theory of Mind skills, subconsciously, to personal investment decisions. In a within-subject repeated-intervention laboratory experiment, we record how the disposition effect is reduced by a very significant 85%, but only for those with high Theory of Mind skills. No such transfer is observed in subjects who score well only on the emotional dimension of interpersonal skills. Our findings open up a promising way to exploit cognitive talents in one domain in order to alleviate cognitive deficiencies elsewhere.
Orai1 Downregulation Causes Proliferation Reduction and Cell Cycle Arrest via Inactivation of the Ras-NF-κB Signaling Pathway in Osteoblasts
Authors: Guo Yunshan , Hao Dingjun 
Published: July 2021

Abstract
Background: The purpose of this study was to determine the role of Orai1 in the regulation of the proliferation and cell cycle of osteoblasts. Methods: The expression of Orai1 was inhibited by Orai1 small interfering RNA (siRNA) in MC3T3-E1 cells. Following Orai1 downregulation, cell proliferation and cell cycle were examined. Furthermore, the expression of cyclin D1, cyclin E, CDK4, and CDK6 was analyzed. The activity of the Ras-NF-κB signaling pathway was investigated to identify the role of Orai1 in the regulation of osteoblast proliferation. Results: Orai1 was successfully downregulated in MC3T3-E1 cells by the Orai1 siRNA transfection (p <0.05). We found that MC3T3-E1 cell proliferation was decreased, and the cell cycle was arrested by Orai1 downregulation (p <0.05). Additionally, the expression of cyclin D1 was decreased by Orai1 downregulation (p <0.05), as was the activity of the Ras-NF-κB signaling pathway (p <0.05). Orai1 siRNA did not further reduce cell proliferation, the proportion of cells in the S phase, and cyclin D1 expression after chemical blockage of the Ras signaling pathway in MC3T3-E1 cells (p >0.05).Conclusions: The results reveal that Orai1 downregulation may reduce cyclin D1 expression by inactivating the Ras-NF-κB signaling pathway thus blocking osteoblast proliferation and cell cycle.
Long-Term Survival of Chlamydomonas Reinhardtii During Conditional Senescence
Authors: Damoo Djihane Yushrina , Durnford Dion 
Published: July 2021

Abstract
Chlamydomonas reinhardtii undergoes conditional senescence when grown in batch culture due to nutrient limitation. Here we explored plastid and photo-physiological adaptations in Chlamydomonasreinhardtiiduring a long-term ageing experiment by methodically sampling them over 22 weeks. Following exponential growth, Chlamydomonas entered an extended declining growth phase where cells continued to divide, though at a lower rate. Ultimately this ongoing division was fueled by the recycling of macromolecules, that was obvious in the rapidly declining protein and chlorophyll content in the cell during this phase. This process was sufficient to maintain a high level of cell viability as the culture entered stationary phase. Beyond that, cell viability starts to plummet. During the turnover of macromolecules after exponential growth that saw RuBisCO levels drop, the LHCII antenna was relatively stable. This, along with the upregulation of the light stress-related proteins (LHCSR), contributes to an efficient energy dissipation mechanism to protect the ageing cells from photooxidative stress during the senescence process. Ultimately, viability dropped to about 7%at 22 weeks in a batch culture. We anticipate that this research will help further understand the various acclimation strategies carried out by Chlamydomonas to maximize survival under conditional senescence.
On occurrence of sudden increase of spiking amplitude via fold limit cycle bifurcation in a modified Van der Pol-Duffing system with slow-varying periodic excitation
Authors: Zhang Xiaofang , Zhang Bin , Han Xiujing , Bi Qinsheng 
Published: July 2021

Abstract
The main purpose of the paper is to reveal the mechanism of certain special phenomena in bursting oscillations such as the sudden increase of the spiking amplitude. When multiple equilibrium points coexist in a dynamical system, several types of stable attractors via different bifurcations from these points may be observed with the variation of parameters, which may interact with each other to form other types of bifurcations. Here we take the modified van der Pol-Duffing system as an example, in which periodic parametric excitation is introduced. When the exciting frequency is far less than the natural frequency, bursting oscillations may appear. By regarding the exciting term as a slow-varying parameter, the number of the equilibrium branches in the fast generalized autonomous subsystem varies from one to five with the variation of the slow-varying parameter, on which different types of bifurcations, such as Hopf and pitch fork bifurcations, can be observed. The limit cycles, including the cycles via Hopf bifurcations and the cycles near the homo-clinic orbit may interact with each other to form the fold limit cycle bifurcations. With the increase of the exciting amplitude, different stable attractors and bifurcations of the generalized autonomous fast subsystem involve the full system, leading to different types of bursting oscillations. Fold limit cycle bifurcations may cause the sudden change of the spiking amplitude, since at the bifurcation points, the trajectory may oscillate according to different stable limit cycles with obviously different amplitudes. At the pitch fork bifurcation point, two possible jumping ways may result in two coexisted asymmetric bursting attractors, which may expand in the phase space to interact with each other to form an enlarged symmetric bursting attractor with doubled period. The inertia of the movement along the stable equilibrium may cause the trajectory to pass across the related bifurcations, leading to the delay effect of the bifurcations. Not only the large exciting amplitude, but also the large value of the exciting frequency may increase inertia of the movement, since in both the two cases, the change rate of the slow-varying parameter may increase. Therefore, a relative small exciting frequency may be taken in order to show the possible influence of all the equilibrium branches and their bifurcations on the dynamics of the full system.
Preoperative Versus Postoperative Chemo-Radiotherapy For Locally Advanced Gastric Cancer: A Propensity Score-Matched Analysis
Authors: Li Ning , Xiang Xiaoyong , Zhao Dongbin , Wang Xin , Tang Yuan , Chi Yihebali , Yang Lin , Jiang Liming , Jiang Jun , Shi Jinming , Liu Wenyang , Fang Hui , Tang Yu , Chen Bo , Lu Ningning , Jing Hao , Qi Shunan , Wang Shulian , Liu Yueping , Song Yongwen , Li Yexiong , Zhang Liyuan , Jin Jing 
Published: July 2021

Abstract
Background: peri-operative chemo-radiotherapy played important role in locally advanced gastric cancer. Whether preoperative strategy can improve the long-term prognosis compared with postoperative treatment is unclear. The study purpose to compare long-term oncologic outcomes in locally advanced gastric cancer patients treated with preoperative chemo-radiotherapy (pre-CRT) and postoperative chemo-radiotherapy (post-CRT). Methods: From January 2009 to April 2019, 222 patients from 2 centers with stage T3/4 and/or N positive gastric cancer who received pre-CRT and post-CRT were included. After propensity score matching (PSM), comparisons of local regional control (LC), distant metastasis-free survival (DMFS), disease-free survival (DFS) and overall survival (OS) were performed using Kaplan-Meier analysis and log-rank test between pre- and post-CRT groups.Results: The median follow-up period was 30 months. 120 matched cases were generated for analysis. Three-year LC, DMFS, DFS and OS for pre- vs. post-CRT groups were 93.8% vs. 97.2% (p=0.244), 78.7% vs. 65.7% (p=0.017), 74.9% vs. 65.3% (p=0.042) and 74.4% vs. 61.2% (p=0.055), respectively. Pre-CRT were significantly associated with DFS in uni- and multi-variate analysis. Conclusion: Preoperative CRT showed advantages of long-term outcome compared with postoperative CRT. Trial registration: ClinicalTrial.gov NCT01291407, NCT03427684 and NCT04062058, date of registration: Feb 8, 2011
Pelvic Obliquity, It Is Not a Neutral Angle in the Normal Population
Authors: Moharrami Alireza , Tamehri Seyed Saeed , Ghasemi Mohammad Ali , Jamshidi Mir Mansour Moazen , Mortazavi Seyed Mohammad Javad 
Published: July 2021

Abstract
Introduction: The definition of pelvic obliquity angle (PO) still unclear in the normal population. Several factors might cause the obliquity i.e. hip osteoarthritis, developmental dysplasia of hip, trauma, scoliosis and spine related factors. Perhaps, pelvic obliquity is expressed as a deviation of neutral alignment in the normal population. We developed present study to evaluate the distribution of pelvic obliquity angle in normal population.Method: present study retrospectively enrolled on 134 cases (70 female and 64 male) without any problem of spine, pelvic and lower extremity abnormality who referred to our institution from January 2017 to January 2018 for non-orthopedic problems. We retrospectively reviewed radiographs from institutional PACS and measured pelvic obliquity angle using mediCAD Classic software (version 3.50.0.1, Hectec, Landstuhl, Germany). Finally, all data were analyzed with SPSS software (version 24.0, USA).Result: present study show that all data has significant relationship in one sample T test. All PO angles were normally distributed in kurtosis and skewness test. The patients were aged with a mean of 39.6 ±16.8 in current study. The mean of PO angle was 2.18 ±1.6 in all patients and 0.13 standard error of mean. There was no significant differences between male and female genders (2.07 ±1.6 vs 2.27±1.6, P=0.47). This study reveal that age and PO angle had not any correlation (P=0.165).Conclusion: despite this fact, there was an attitude that PO angle normally is in neutral alignment, our result uncover that the normal range of PO angle was not neutral and ranged from 0.58 to 4.4 degrees with one standard deviation from mean in the normal population.
High Heritability of Glycyrrhizic Acid, Glabridin, Liquiritin and Liquiritigenin in Licorice (Glycyrrhiza Glabra L.) Populations of Iran
Authors: Eghlima Ghasem , Sanikhani Mohsen , Kheiry Azizollah , Hadian Javad 
Published: July 2021

Abstract
Glycyrrhiza glabra L. is an herbaceous, perennial plant with high distribution in Iran. Genetic variability, heritability and correlation among characters in 22 populations of G. glabra L. were studied. The genetic parameters among the traits including phenotypic variances, genotypic variances, genotype by environment variances, broad-sense heritability and genotypic and phenotypic correlation coefficients were studied. Variance components analysis showed that the extent of phenotypic coefficient of variation (PCV) was fairly higher for all the examined traits compared with genotypic coefficient of variation (GCV). Glabridin (GLA) exhibited high GCV and PCV (156.07% and 156.68%, respectively). The broad sense heritability varied from 38.92–99.79% and narrow sense heritability ranged from 9.70 % to 24.94%. Heritability of GLA, glycyrrhizic acid (GLY), liquiritin (LI), liquiritigenin (LIQ), rutin (RU) and rosmarinic acid (RA) were very high, exhibiting more than 97% heritability. Therefore, these critical characteristics can efficiently be selected and inherited in breeding programs. In most traits, the genotypic correlations showed the same direction as the phenotypic correlations. The contents of GLA and LIQ showed a positive correlation with majority of morphological traits. Therefore, selecting individual plants having desired morphological traits can be correlated with high contents of bioactive compounds in the harvested root.
Effectiveness of Prosthetic Rehabilitation and Quality of Life of Older Edentulous Head and Neck Cancer Survivors Following Resection of the Maxilla. A Cross-sectional Study
Authors: Artopoulou Ioli Ioanna , Sarafianou Aspasia , Perisanidis Christos , Polyzois Gregory 
Published: July 2021

Abstract
PurposeTo evaluate the effectiveness of the prosthetic rehabilitation, as well as the quality of life (QOL) of older edentulous maxillectomy patients.MethodsEffectiveness of the complete denture obturator prosthesis and QOL of 44 older patients who had resection of the maxilla and were restored with a definitive prosthesis that was in use for minimum 1 year was assessed using 3 instruments: European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (QLQ-C30), Head and Neck Cancer Module (QLQ-HN35), and Obturator Functioning Scale (OFS). Data analysis was performed by the one-way ANOVA on ranks, Spearman rank order correlation, and hierarchical multivariable rank regression at α=.05 level of significance.ResultsParticipants’ gender (P<.001), adjuvant treatment (P =.016), surgical approach (P =.017), size of the maxillary defect (P=.028), participants’ prosthetic history (P =.047), and dental status of the mandible (P =.038) were significantly related to the self-reported effectiveness of the obturator. Perceived functioning of the complete denture obturator prosthesis (P=.001), participants’ gender (P=.002), the American Society of Anesthesiologists (ASA) physical status (P=.027), and surgical approach (P=.039) were significant predictors of QOL. ConclusionRestoration of the edentulous maxillectomy defect is challenging. An effective definitive complete denture obturator appeared to be the strongest predictor for advanced quality of life in older maxillectomy patients. The physical status of the older participants significantly affected the overall QOL, but did not influence the self-reported functioning of the complete denture obturator prosthesis.