bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cultural and Linguistic Adaptation for the Romanian Language Version of the Cardiff Acne Disability Index: A Pilot Study on the Web-Based Experience of Cognitive Debriefing
Authors: Cretu Stefana , Salavastru Carmen Maria 
Published: December 2021

Background
The Cardiff Acne Disability Index (CADI) is a validated measurement instrument for quality of life evaluation in young patients with acne. The original version was designed in English, and it has been translated to other languages. An adaptation for the Romanian language was lacking.

Objective
The main objective of this study was to evaluate the comprehensibility of the Romanian language adaptation of the CADI in a small sample of patients with acne.

Methods
Guided by the team at Cardiff University, we conducted the stages of the standardized translation process—forward translation, the reconciliation of translated versions, back translation, and cognitive debriefing. The cognitive debriefing stage involved applying the CADI to a small sample of patients. This was followed by individual interviews in which each question was discussed. Ethical approval was obtained for the cognitive debriefing stage. We administered this measure as a web-based form. The completion times for each individual question and for the entire survey were automatically recorded. The interviews for assessing comprehensibility and suitability for the Romanian language and culture were also held as live, web-based meetings.

Results
A total of 7 patients with acne—4 females and 3 males—aged between 19 and 34 years were included. All subjects were native speakers of the Romanian language. They had mild or moderate acne. The mean completion time for the survey was 3.28 minutes. The mean score for the CADI was 5.4286. All participants agreed that the language used in this quality of life measurement instrument was simple, clear, and adequate for their native language.

Conclusions
Despite the epidemiologic restrictions against COVID-19, through teledermatology, we achieved cultural adaptation for the CADI in a language that previously lacked a specific tool for assessing quality of life impairment in patients with acne.

Conflicts of Interest
CMS receives royalties from Springer Nature, consulting fees from Vichy International, and support for attending meetings from Leo Pharma. SC has no conflicts of interest.
Crusted Scabies as a Suitable Disease for Teledermatology: A Study of 2 Cases
Authors: Bimbi César , Dalla Lana Daiane Flores , Brzezinski Piotr , Kyriakou Georgia 
Published: December 2021

Background
Teledermatology has been available for several years now, but the COVID-19 pandemic has highlighted its importance, especially in remote communities. Crusted scabies (CS) presents a unique clinical picture that favors telediagnosis. Patients with neurological diseases, as well as homeless, HIV-infected patients and people with impaired immunological function, are at risk. Clusters of CS have been reported in French Guyana, and these were associated with human T-lymphotropic virus infections. CS has also been reported in Aboriginal Australian communities.

Objective
Teledermatology is especially useful in cases of CS, as it is a disease that affects areas that are in need of medical services. At the same time, CS presents a unique clinical picture. The objective of this presentation is to fuel the clinical suspicion and detection of patients with this debilitating condition.

Methods
Relatives of patient 1 contacted our clinic for teledermatology appointments. General practitioners from health services sent images of the second patient.

Results
Case 1 involved an older woman living in a nursing home with Alzheimer disease, which was severe enough to constrain her to bed. We recommended that her relatives (who had sent images) collect skin scrapings in a container. These scrapings were sent to a clinical analysis laboratory where microscopic potassium hydroxide preparation revealed the presence of Sarcoptes mites. Treatment with oral ivermectin and topical permethrin resulted in the complete resolution of the lesions. Case 2 involved a homeless, HIV-positive, 42-year-old male. The images were sent by clinicians from local health services. This patient was also treated with oral ivermectin and permethrin lotion. We recognize that this case would need further diagnostic workup, but it is highly indicative of CS.

Conclusions
CS is one of the most suited diseases for the practice of teledermatology for widespread, large, hyperkeratotic fissured plaques covered with abundant, silvery scales for which the expression “once seen, never forgotten” is highly applicable. These cases are gratifyingly simple to treat, and patients benefit from rapid clinical improvement. Prompt diagnoses prevent outbreaks of scabies for relatives and medical personnel, since these skin crusts contain large numbers of scabies mites. CS has been increasingly reported but poorly recognized, and it has often been misdiagnosed as psoriasis. Images, such as those shown in this presentation, are unique and are enough to raise strong clinical suspicion.

Conflicts of Interest
None declared.
Identifikasi Potensi Wisata di Desa Banjaran Wetan
Authors: Kurniawan Kunkun 
Published: December 2021

Desa Banjaran Wetan merupakan salah satu desa di wilayah Kecamatan Banjaran Kabupaten Bandung yang belum memiliki destinasi pariwisata. Secara geografis, Desa Banjaran Wetan memiliki wilayah yang paling luas di Kecamatan Banjaran. Salah satu potensi alam di wilayah Desa Banjaran Wetan yang dapat dikembangkan menjadi sebuah destinasi pariwisata berkelanjutan adalah Situ Cimeuhmal. Situ Cimeuhmal terletak di kaki Pegunungan Malabar dengan luas wilayah kawasan hutan lindung sebesar 46,5 hektar dan ketinggian 1.200 mdpl. Pemangku kepentingan yang terlibat dalam pengelolaan kawasan Situ Cimeuhmal terdiri dari PT. Perhutani, BBWS Citarum, PT Jasa Tirta, Komunitas Anak Peduli Alam Semesta, dan Kelompok Peduli Lingkungan Situ Cimeuhmal. Pengembangan Situ Cimeuhmal menjadi destinasi pariwisata berbasis konservasi air terkendala kordinasi dan role sharing diantara pemangku kepentingan. Tujuan penelitian ini untuk mengidentifikasi potensi wisata di Desa Banjaran Wetan serta strategi pengembangan destinasi pariwisata Situ Cimeuhmal yang sejalan dengan prinsip pariwisata berkelanjutan. Metode penelitian dilakukan secara kualitatif dengan teknik pengumpulan data melalui observasi, wawancara, dan studi literatur. Hasil penelitian menunjukkan bahwa Desa Banjaran Wetan memiliki potensi wisata alam dan non alam yang dapat dikembangkan menjadi destinasi pariwisata. Berdasarkan hasil analisasi SWOT, Situ Cimeuhmal memiliki potensi alam yang menarik untuk dijadikan destinasi pariwisata berbasis konservasi sumber daya air meskipun dari tinjauan atribut pariwisata belum memenuhi kriteria dengan baik. Atraksi yang ditawarkan kepada wisatawan masih terbatas pada keindahan kawasan yang asri, sejuk dengan kolam air dan event yang diselenggarakan tahunan kawin cai. Akses menuju lokasi destinasi kurang baik. Fasilitas untuk kenyamanan wisatawan seperti homestay atau pondokan belum tersedia. Potensi non alam yang dapat dikembangkan di Desa Banjaran Wetan adalah produk makanan ringan kerupuk, kopi dan beragam produk olahannya.
Teniases caused by <i>Taenia asiatica, Taenia saginata, Taenia solium</i>
Authors: Chuelov S. B. , Rossina A. L. 
Published: December 2021

The urgency of the problem of human teniases is due to the widespread prevalence of these parasitoses, which often infect humans.The aim and result of the work is to summarize the available information about the etiology, epidemiology, pathogenesis, clinical picture, diagnosis, etiotropic therapy and prevention of human teniases.Conclusion. Teniases are widespread, including on the territory of Russia. The clinic mainly includes symptoms of lesions of the gastrointestinal tract, allergic reactions. Diagnostics is carried out on the basis of the detection of eggs, proglottids, coproangigens of parasites in the feces, serological and molecular genetic tests. Praziquantel is an effective etiotropic therapy. Prevention takes into account the peculiarities of the epidemiology of teniases.
Does Mode of Access Make a Difference? Mobile Learning and online student engagement
Authors: Nichter Sarah 
Published: December 2021

Even though student use of mobile devices for educational purposes has increased in recent years, the research on the possible impact on student success or engagement has been minimal. This study investigated the impact of mobile device use on student engagement and student success in online courses. The theory of Self-Regulated Learning (SRL) was a foundation for understanding and measuring engagement behaviors of online students. The Online Self-Regulated Learning Questionnaire (OSLQ) was the basis of the survey instrument. Participants were categorized into three groups of mobile device use (low, moderate, high). These three groups were used for comparison in each of the research questions. The research questions ask what impacts mobile learning has on student engagement, as measured with SRL; what impact mobile learning has on the SRL constructs of environment structuring, task management, and time management; and what associations mobile learning might have with student success and persistence. The ANOVA showed that mobile learning had a moderate impact on engagement for students in the high group. Students in each group engaged in environment structuring behaviors more than task strategies or time management behaviors. Students in the moderate and high groups engaged in task strategies more than the low group. Students in the high group engaged in time management behaviors more than the other groups. The Crosstab analysis did not show an association between levels of mobile learning and course grade or persistence. These findings have positive implications for online pedagogy and course design. Keywords: Mobile Learning; online learning; student engagement; Self-Regulated Learning; student success
In Memorium: Dr. Karen Swan
Authors: Shea Peter 
Published: December 2021

The community that makes up the Online Learning journal lost a colleague, leader, and dear friend recently. Dr. Karen Swan, a founding member of the Online Learning Consortium and the James J. Stukel Distinguished Professor of Educational Leadership at the University of Illinois Springfield passed away on September 5, 2021. Karen was a central figure on the editorial board of this journal and we will miss her wisdom, kindness, and spirit.
Optimization of damaging perinatal factors diagnosing in intrauterine growth restriction
Authors: M. V. Маkаrenko  , О. A. Кuzmina  
Published: December 2021

74 pregnant women with the symmetric form of intrauterine growth restriction (IUGR) at the term of pregnancy of 27-40 weeks were involved in the study. The conducted analysis showed that the principal cause of symmetric form of IUGR is the complicated course of pregnancy: gestosis (55 %) and protracted threat of pregnancy interruption (35 %). The obtained results allowed to distinguish the criteria of fetal chronic hypoxia and attribute them to the damaging perinatal factors in IUGR.
A case of late diagnosing dermal focal hypoplasia in a child
Authors: N. I. Pidvysotska  , I. V. Lastivka  , L. V. Boiko  , I. M. Valуhurskyі  
Published: December 2021

Dermal focal hypoplasia is a rare X-linked dominant mesoectodermal disorder. The described case of Goltz’s syndrome shows clinical manifestations, a need for a multidisciplinary assessment, diagnostic and continuous monitoring of this pathology.
Specific characteristics of teaching pharmacology to foreign students under conditions of credit-module education system
Authors: I. B. Samura  
Published: December 2021

The design of physician programs creates special challenges for providing pharmacology education. The article presents examples pertaining to improving teaching methods in pharmacology to foreign students at Medical Department. The paper has revealed peculiarities of theoretical knowledge and practical skills acquisition in the process of teaching pharmacology, and the stimulation technics for cognitive interest of students have been discussed. In particular, it has been analyzed the contributing factors that prove the need for the introduction and regular application of interactive teaching methods, testing students, the discussion of complex and unresolved scientific problems of dynamic and constantly developing science of pharmacology, and its interaction with other modern biomedical sciences.
The state of carbohydrate and lipid metabolism and glomerular filtration rate in patients with degree II hypertensive disease associated with type II diabetes
Authors: S. V. Biletskyi  , O. Z. Novytska  , O. A. Petrynych  , T. V. Kazantseva  
Published: December 2021

The article deals with the state of carbohydrate and lipid metabolism, its interrelation with glomerular filtration rate (GFR) in patients with degree II hypertensive disease (degree II HD) associated with type II diabetes mellitus (insulin-independent DM). The patients being examined revealed hyperinsulinemia, insulin-resistance and dyslipidemia, which with concomitant type II DM are more pronounced. There is a tendency to hyperfiltration in patients with II degree HD and significant decrease of GFR with concomitant development of II degree HD and type II DM. disorders of lipid and carbohydrate metabolism in patients with II degree HD and concomitant type II DM are found to be as risk factors in the development of kidney afflictions.
Influence of vitamins C and E on lipid peroxidation processes and the activity of NO-synthase system in pancreas of rats with the epinephrine-induced stress
Authors: T. I. Bondarchuk  
Published: December 2021

Influence of vitamins (Vit) C and E on the lipid peroxidation processes and activity of NO-synthase system in the pancreas of rats with the epinephrine-induced stress was studied. It was ascertained that Vit C decreased TBA-active products content as well as superdismutase activity more than Vit E under the same conditions. However the decrease of general NOS, eNOS activities and the content of NO2 - was more considerable in group with Vit E as compared to the action of Vit C. Both vitamins decreased the activity of iNOS equally. Combined action of Vit C and E under condition of epinephrine-induced stress reduced activity of general NOS and iNOS and the content of NO2 - more substantially from those treated with Vit independently, however there was no summation of their effects on studied processes.
Comparision influence of conditioned medium of human mesenchimal cells and interferon-α on development of tumor cell population
Authors: T. S. Herheliuk  , O. M. Perepelytsina  , M. V. Sydorenko  
Published: December 2021

This work is a study of mediators and mechanisms of the effect of human mesenchymal stem cells from bone marrow (hMSC BM) on the tumor cell population line MCF-7 (breast adenocarcinoma). It is known that MSCs produce a wide range of cytokines and chemokines, and provide humoral cells interaction. BM MSCs produce tumor necrosis factor (TNF-α), interleukin (IL-1β, IL-2, IL-4, IL-6, IL-8), interferon-alpha (IFN-α). In this study we compared the proliferation, adhesion, survival and antigenic profile of breast adenocarcinoma cells that were cultured with conditioned medium (с-medium) of the MSC and IFN-α. Consequently, it was found that с-medium from MSC inhibited proliferation activity of MCF-7, increased cells adhesion, suppressed the ability to migrate, and reduced the expression of estrogen receptor and epidermal growth factor receptor. Conversely expression of cytokeratins increased, which is a positive sign for the tumor cells of epithelial origin. IFN-α showed a more pronounced effect on the tumor population. These findings suggest that cryopreserved MSC BM has antitumor activity. Also, our data suggest that IFN-alpha is one of the mediators of antitumor effect of MSCs.
Features of exercise induced bronchial asthma course in schoolchildren with polymorphisms in glutation-s-transferase genes
Authors: Koloskova O. K. , Hryhola O. G. , Bilous T. M. , Ortemenka Ye. P. 
Published: December 2021

With respect to the principles of bioethics, on the base of allergy department of Chernivtsi Regional Children's Hospital it has been conducted a comprehensive clinical and paraclinical examination of 51 children with symptoms of exercise induced asthma phenotype depending upon the presence or the absence of genes polymorphism of the enzymes of glutation-S-transferase – GSTT1M1. The study showed that the course of the disease was more severe in the patients with deletions of the mentioned genes, though with more rapid effect of standard reliever treatments as compared to the patients with genotype GSTT1+M1+. The patients with exercise-induced asthma in the presence of deletion genes polymorphisms of GSTT1M1 (GSTT1delM1del, GSTT1+M1del or GSTT1delM1+) require a special attention to their environmental enhancement and normalization of their life-style.
Dynamic parameters of homeostasis under the influence of antiaggregant treatment in patients with atrial fibrillation and metabolic syndrome
Authors: M. A. Orynchak  , M. M. Vasylechko  
Published: December 2021

The condition of coagulation and platelet hemostasis in 125 patients with atrial fibrillation (AF) and with metabolic syndrome (MS) has been analysed. Сoagulation and platelet hemostasis in 125 patients with AF and MS under treatment with acetylsalicylic acid (ASA) (group 1), omega-3 polyunsaturated fatty acids (omega-3 PUFAs) (group 2) and ASA with L-arginine (3 group) during 2 months were measured. It was established that omega-3 PUFAs are more effective compared with ASA/aspirin with L-arginine and it promotes normalization of fibrinogen, soluble fibrin-monomer complexes (SFMK), D-dimer and improves the platelet aggregative activity (PAA).
Some aspects of pathogenesis of erosive-ulcerous gastric lesions in liver cirrhosis patients
Authors: Palibroda N. M. , Fediv O. I. 
Published: December 2021

Von Willebrand factor, tumor necrosis factor-α levels and portal bloodstream were examined in 47 patients with liver cirrhosis and 8 apparently healthy persons. The increase of von Willebrand factor and tumor necrosis factor-α levels were found to lead to the development of erosive-ulcerative lesions of gastric mucosa. The abnormalities of portal resistance, von Willebrand factor and TNF-α are interrelated data which play a certain role in occurrence of erosive-ulcerative lesions of gastric mucosa in patients with liver cirrhosis.
Comparative analysis of monocyesis and multiple gestation course after in vitro fertilization and embriotransfer
Authors: L. I. Sehedii  , О. I. Prokopiv  
Published: December 2021

The data of comparative clinical and statistical analysis of gestation process and pregnancy outcome after IVF & ET in the observation period from 2008 through 2012 have been presented. For a set of initial parameters (age structure; cases, duration and infertility factors, the choice of controlled ovarian stimulation protocol) the studied groups did not differ. It has been concluded, that multiple gestation has a aggravating impact on pregnancies achieved in the result of IVF & ET, which was manifested in statistically more frequent, in comparison to monocyesis, cases of late miscarriage threat, intrauterine growth retardation of fetus (fetuses), preterm labour, adverse perinatal outcomes instances, which has been supported by the corresponding findings of the research in both monocyesis and multiple pregnancy groups. A substantial role in aggravating impact on pregnancy also refers to anemia, which statistically more frequently develops in women with a multiple gestation in comparison to those with monocyesis.
Enterobiasis caused changes in the mucous and skin of female genital tract
Authors: V. O. Skliarova  , K. I. Bodnia  
Published: December 2021

The paper presents the changes in the skin of the external genitalia and perianal area, as well as in the mucous caused by enterobiasis. Enterobius vermicularis infestation has been identified in 60 % of patients with changes in the skin and mucous membranes. The influence of mature pinworms and their eggs on the vulva, causes a local reaction, which is accompanied by itching, discomfort, swelling, change in consistency and color of vaginal discharge. Only in 30 % of infected patients the complaint "night itch" was noted. Colposcopy changes of the vaginal mucosa and cervix have been detected in all women with enterobiasis.
Evaluation of control over the bronchial asthma in period of clinical well-being in teenagers depending on the severity of the bronchial inflammation
Authors: O. O. Shakhova  , I. B. Sichkar  
Published: December 2021

At the basis of a complex examination of 63 adolescents it was revealed, that the signs of local inflammation in the bronchi and the increase of their nonspecific hyperresponsiveness remained in some of patients with asthma during the clinical well-being period with the absence of clinical symptoms. It was shown that the lower than 40.0 mmol/l content of nitrogen monoxide metabolites in the condensate of exhaled air increases the likelihood of retention of control: relative risk = 4,3 (while assessing the level of control by the ACT questionnaire) and 5,5 – in the evaluation of control level by the GINA questionnaire. Due to this the basic therapy is effective in almost every child, because the minimal number of patients needed to be treated to obtain a positive result is 1,3, according to ACT and GINA tests.
Statistical indicators of epidemiology of colorectal cancer among the population of Chernivtsi region, Ukraine and world
Authors: V. V. Shulhina  , O. I. Ivashchuk  , S. Y. Kravchuk  , I. Y. Hushul  
Published: December 2021

Statistics indicators of prevalence, incidence and mortality caused by colorectal cancer in the population of the world, Ukraine and residents of Chernivtsi region with conducted taking into consideration patients’ gender and stage of disease.
Hormonal changes in women of late reproductive, perimenopausal and postmenopausal age with urogenital disorders
Authors: A. P. Hryhorenko  , O. G. Shymanska-Horbatiuk  , V. M. Kucheruk  , O. A. Poliovyi  
Published: December 2021

Investigation of hormonal homeostasis in 51 women with urogenital disorders (urogenital prolapse, vaginal atrophy, urinary incontinence) and 10 healthy women (control group) was carried out. There was studied the concentration of pituitary-ovarian hormones, thyroid and adrenal glands hormones. The hormonal research showed a significant reduction of gonadotropins, prolactin, total testosterone, DHEA-S, cortisol in women of late reproductive age with urogenital disorders. In perimenopausal and postmenopausal women with urogenital disorders gonadotropins and TSH rates increased. Levels of prolactine, estradiol, progesterone, testosterone total, DHEA-S and cortisol reduced. In perimenopausal women with urogenital disorders level of total thyroxine (Т4) was significantly elevated.
The effect of rheosorbilact on the regulation mechanisms of sodium balance of sepsis patients
Authors: V. M. Konovchuk  , A. V. Andrushchak  , S. O. Akentiev  
Published: December 2021

The article examines the effect of rheosorbilact on the regulation mechanisms of sodium balance of sepsis patients. It has been concluded that because of the filtration mechanisms damage the reduction of sodium filtration fraction is the result of the sodium balance impairment which is the component of ion-osmo and volume-regulative kidney function of severe sepsis patients.