bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential Involvement of Extracellular Citrate in Brain Tumor
Progression
Authors: Jordan Katrin , Stanton Evan H. , Milenkovic Vladimir M. , Federlin Marianne , Drexler Konstantin , Buchalla Wolfgang , Gaumann Andreas , Adamski Jerzy , Proescholdt Martin , Haferkamp Sebastian , Geissler Edward K. , Mycielska Maria E. 
Published: March 2021

Abstract:
Brain tissue is known to have elevated citrate levels, necessary to regulate
ion chelation, neuron excitability, and are also necessary for the supply of necessary
energy substrates to neurons. Importantly, citrate also acts as a central substrate in
cancer metabolism. Recent studies have shown that extracellular citrate levels in the
brain undergo significant changes during tumor development and may play a dual role in
tumor progression, as well as cancer cell aggressiveness. In the present article, we
review available literature describing changes of citrate levels in brain tissue, blood, and
cerebrospinal fluid, as well as intracellular alterations during tumor development before
and after metastatic progression. Based on the available literature and our recent
findings, we hypothesize that changes in extracellular citrate levels may be related to the
increased consumption of this metabolite by cancer cells. Interestingly, cancerassociated
cells, including reactive astrocytes, might be a source of citrate. Extracellular
citrate uptake mechanisms, as well as potential citrate synthesis and release by
surrounding stroma, could provide novel targets for anti-cancer treatments of primary
brain tumors and brain metastases.
Halloysite Nanotubes Functionalized Sulfonic Acid: Synthesis, Spectroscopic Characterization, Computational Studies and Application for the Synthesis of 1,4-Dihydropyridines
Authors: Gupta Princy , Prakash Nayan , Ramawat Yogeshwar , Rajput Palvi , Fayaz Amir , Roy Tapta Kanchan 
Published: March 2021

:In this study, naturally occurring clay halloysite has been used to synthesize novel halloysite functionalized sulfonic acid in two steps, i.e. functionalization followed by oxidation, and its catalytic activity has been estimated for one-pot synthesis of Hantzsch 1,4-dihydropyridines under green solventfree conditions. Spectroscopic studies such as FTIR, TGA, elemental analysis and first-principles-based quantum chemical studies have been employed to characterize the catalyst. Recyclability without significant loss of catalytic activity has been observed for several runs.
Synthesis and Anti-cancer Activity of Paclitaxel−Coumarin Conjugate
Authors: Song Zurong , Lu Qin , Tao Ali , Wu Tianchen 
Published: March 2021

Background:
Paclitaxel, a natural diterpenoid compound, has anti-tumor effect by acting on tubulin,
whereas coumarin, another kind of natural product, has anti-tumor effect, along with some other effects, such as
anti-bacterial-., Moreover, it also possesses fluorescence.

Objective:
Multi targeting is an effective strategy in drug design to combat tumor. Therefore, a combination of
paclitaxel with other active molecular drugs for exploring the novel lead with multi-functions is in demand.

Materials and Methods:
To synthsize paclitaxel-coumarin conjugate via click chemistry and to investigate anticancer
activity by MTT assay and the scratch test.

Results and Discussion:
The results of MTT assay showed that compared tothe paclitaxel, the anti-tumor activity
of the conjugate was significantly improved. The results of flow cytometry showed that the conjugate had a
stronger ability to induce apoptosis. The scratch test results showed that the conjugate had better anti- metastasis
ability than paclitaxel.

Conclusion:
These findings indicated that paclitaxel and coumarin had a synergistic effect, which paved the way
for the development of paclitaxel through fluorescence.
Lynch Syndrome Identification in Endometrial Cancer Patients: Should
Universal Screening be Used for all Histologies?
Authors: Parker Jessica E. , Mauer Caitlin , Zheng Wenxin , Miller David S. , Lea Jayanthi S. 
Published: March 2021

Background:
There is an increased proportion of non-endometrioid histologies in
Lynch syndrome-associated compared to sporadic endometrial cancer; however, screening recommendations
do not differ between type I and type II cancers.

Objective:
Our objective was to examine the frequency of Lynch syndrome identified in type I and
type II endometrial cancers and their associated characteristics.

Methods:
We reviewed patients with type I and type II endometrial cancer who were screened for
Lynch Syndrome or referred for genetic testing according to an age and family history-based
screening protocol. All patients were seen and treated at a large academic institution affiliated with
a county safety-net hospital. Clinical, pathologic, immunohistochemistry, and germline genetic testing
results were obtained as well as the choice of genetic screening approach, personal and family
history, and compliance with testing were assessed.

Results:
234 women with type I and 29 patients with type II endometrial cancer were identified.
Lynch syndrome was diagnosed in a total of eight (3.4%) type I endometrial cancer patients, all
identified after age-based tumor screening. In type II endometrial cancer group, three (10.3%) patients
had Lynch syndrome. One was referred for testing after abnormal immunohistochemistry
screening under age 60. The other two were >60 years old and identified after abnormal immunohistochemistry
screening performed on physician’s request.

Conclusion:
Age-based screening may not diagnose Lynch Syndrome in women with type II endometrial
cancers. Our findings underscore the need for a universal screening approach in patients
with type II endometrial cancers, even in a low-resource population.
Pharmacological Treatment of Diabetic Peripheral Neuropathy: An
Update
Authors: Rafiullah Mohamed , Siddiqui Khalid 
Published: March 2021

:
Neuropathy is the most common complication of diabetes. 50% of adults with diabetes
will develop neuropathy in their lifetime. Diabetic peripheral neuropathy (DPN) is the major form
of neuropathy found in 75% of diabetic neuropathy incidences. Pharmacological treatments are recommended
for pain management in DPN. Anticonvulsants like pregabalin and gabapentin are the
preferred first-line treatment, followed by amitriptyline, duloxetine, and venlafaxine. Topical
agents like capsaicin and isosorbide dinitrate are also useful in treating the DPN and may be considered
for the second or third-line treatment. Opioids and related drugs are suggested for short-term
use during the acute exacerbation of pain. Combination therapy may be beneficial in patients who
do not respond to monotherapy. However, currently, there is no compelling evidence to suggest
any specific combination of agents. Disease-modifying agents such as alpha-lipoic acid and epalrestat
appear to improve the disease state but are not recommended by any guideline. This review discusses
the available pharmacological therapy for treating DPN. Also, we highlight the recommendations
from different guidelines about the pharmacological treatment of DPN.
Preparation of Fe2O3-ZnO Nanocomposites: Structure and Optical Properties
Authors: Farahmandjou Majid , Hoseini Fatemeh 
Published: March 2021

Background:
The synthesis of Fe2O3/ZnO nanocomposites has gained wide acceptance
in recent years due to its magnetic, photoluminescence and catalytic properties, and
as an active element in gas sensors. This type of composite particle has potential biological
and biomedical applications such as the detection of cancer cells, bacteria and viruses, and
for magnetic separation.

Objective:
In the present study, first we synthesized the Fe2O3/ZnO nanoparticles, and then
the structural, optical and surface morphological properties were investigated by XRD,
HRTEM, FESEM, XRF and FTIR analyses.

Methods:
Fe2O3-ZnO nanoparticles were fabricated by a solgel synthesis method by combining
iron chloride hexahydrate and zinc sulfate heptahydrate. In the beginning, 2g of
Polyvinylpyrrolidone (PVP) stabilizer was dissolved in 100 mL deionized water and then 5
g FeCl3 was added to the solution with stirring at room temperature. Then 5g of ZnSO4
was added to the solution and synthesis temperature was increased to 100 °C. The product
was evaporated for 3 hours, cooled to room temperature and finally calcined at 600 °C for
3 hours.

Result:
The XRD results showed single-phase Fe2O3-ZnO nanocomposites with a hexagonal
wurtzite structure of ZnO and spinel phase of rhombohedral α-Fe2O3. The crystallite
size of as-prepared sample was determined at about 45 nm and annealed one was calculated
around 40 nm. The SEM images showed that the Fe-Zn nanoparticles changed from
spherical shape to rod shape by increasing the temperature after annealing. The TEM studies
showed the core-shell nanoparticles with a mean diameter of 47 nm. The sharp peaks in
the FTIR spectrum determined the stretching vibrations of Fe and Zn groups in the frequencies
of 620, 565 cm-1 and 410 cm-1.

Conclusion:
The XRD data indicates a single-phase Fe2O3-ZnO structure. The SEM images
show that the nanoparticles changed from sphere-like shape to rod-like shape by increasing
the annealing temperature. TEM image exhibits the core-shell Fe-Zn nanoparticles
with an average diameter of about 37 nm. From the FTIR data, it is shown that the
presence of Fe-Zn stretching mode and the intensity of the peaks increased by increasing
the annealing temperature. XRF analysis showed peaks of iron and ferrite elements, and an
increase in the Zn weight percent was observed from 26.35 %Wt. to 49.26 %Wt. with increasing
temperature.
Civic education di Negara Korea Selatan dan Inggris
Authors: Fauziah Fatikha 
Published: March 2021

Pendidikan diyakini berperan penting dalam memajukan peradaban bangsa. Hampir setiap negara menanamkan kewarganegaraan melalui pendidikan dengan cara yang berbeda-beda. Perbedaan ini dilatarbelakangi oleh perkembangan sejarah, ekonomi, identitas nasional, dan budaya setiap negara. Artikel ini bertujuan untuk menganalisis pendidikan kewarganegaraan di Korea Selatan dan Inggris dengan menggali atribut yang melatarbelakanginya. Kedua negara dipilih karena memiliki kesebandingan yakni maju dalam bidang industry. Hasil telaah menunjukkan bahwa terdapat perbedaan kurikulum pendidikan kewarganegaraan di kedua negara. Inti dari pendidikan kewarganegaraan (civic virtue) di Korea Selatan berasal dari budaya dan keyaninan, yakni budaya konfusianisme dan agama leluhur. Sedangkan, inti pendidikan kewarganegaraan di Inggris berasal dari sejarah dan ideologinya. Kata kunci: Pendidikan kewarganegaraan, Korea Selatan, Inggris
Peningkatan motivasi membaca permulaan melalui metode scramble kalimat pada siswa Kelas 2 SDN Pandeyan Yogyakarta
Authors: Sayekti Octavian Muning 
Published: March 2021

Penelitian ini bertujuan untuk meningkatkan motivasi belajar siswa pada aspek membaca permulaan di kelas 2 SD Negeri Pandeyan. Teknik yang digunakan untuk mengumpulkan data adalah pengamatan atau observasi, angket, wawancara, dan tes. Teknik analisis data yang digunakan dalam penelitian ini adalah teknik deskripsi komparatif. Peneliti membandingkan hasil sebelum penelitian dengan hasil pada akhir setiap siklus. Selain itu juga digunakan teknik analisis kritis dengan tujuan untuk mengungkapkan kelebihan dan kekurangan kinerja siswa dan guru selama proses kegiatan belajar mengajar. Hasil penelitian ini menunjukkan bahwa motivasi membaca permulaan siswa dalam pembelajaran tematik muatan bahasa Indonesia kelas 2 SD Negeri Pandeyan dapat ditingkatkan dengan menerapkan metode scramble. Peningkatan tersebut dapat dilihat sebagai berikut: (1) Pada siklus I meningkat menjadi 50% serta 85% siswa menyatakan senang mengikuti pembelajaran. antusiasme siswa dalam pembelajaran terjadi peningkatan pada siklus I 57% menjadi 78% pada siklus II. Keaktifan siswa dalam apersepsi pada siklus I 50% meningkat menjadi 78% pada siklus II. Selanjutnya untuk keaktifan siswa selama proses KBM pada siklus I 57% meningkat menjadi 78% pada siklus II. Kemudian untuk keaktifan siswa dalam kegiatan tanya jawab pada siklus I 50% menjadi 64% pada siklus II.
Extracting Family History Information From Electronic Health Records: Natural Language Processing Analysis
Authors: Rybinski Maciej , Dai Xiang , Singh Sonit , Karimi Sarvnaz , Nguyen Anthony 
Published: March 2021

Background
The prognosis, diagnosis, and treatment of many genetic disorders and familial diseases significantly improve if the family history (FH) of a patient is known. Such information is often written in the free text of clinical notes.

Objective
The aim of this study is to develop automated methods that enable access to FH data through natural language processing.

Methods
We performed information extraction by using transformers to extract disease mentions from notes. We also experimented with rule-based methods for extracting family member (FM) information from text and coreference resolution techniques. We evaluated different transfer learning strategies to improve the annotation of diseases. We provided a thorough error analysis of the contributing factors that affect such information extraction systems.

Results
Our experiments showed that the combination of domain-adaptive pretraining and intermediate-task pretraining achieved an F1 score of 81.63% for the extraction of diseases and FMs from notes when it was tested on a public shared task data set from the National Natural Language Processing Clinical Challenges (N2C2), providing a statistically significant improvement over the baseline (P<.001). In comparison, in the 2019 N2C2/Open Health Natural Language Processing Shared Task, the median F1 score of all 17 participating teams was 76.59%.

Conclusions
Our approach, which leverages a state-of-the-art named entity recognition model for disease mention detection coupled with a hybrid method for FM mention detection, achieved an effectiveness that was close to that of the top 3 systems participating in the 2019 N2C2 FH extraction challenge, with only the top system convincingly outperforming our approach in terms of precision.
The Value of Routinely Collected Data in Evaluating Home Assessment and Modification Interventions to Prevent Falls in Older People: Systematic Literature Review
Authors: Daniels Helen , Hollinghurst Joe , Fry Richard , Clegg Andrew , Hillcoat-Nallétamby Sarah , Nikolova Silviya , Rodgers Sarah E , Williams Neil , Akbari Ashley 
Published: March 2021

Background
Falls in older people commonly occur at home. Home assessment and modification (HAM) interventions can be effective in reducing falls; however, there are some concerns over the validity of evaluation findings. Routinely collected data could improve the quality of HAM evaluations and strengthen their evidence base.

Objective
The aim of this study is to conduct a systematic review of the evidence of the use of routinely collected data in the evaluations of HAM interventions.

Methods
We searched the following databases from inception until January 31, 2020: PubMed, Ovid, CINAHL, OpenGrey, CENTRAL, LILACS, and Web of Knowledge. Eligible studies were those evaluating HAMs designed to reduce falls involving participants aged 60 years or more. We included study protocols and full reports. Bias was assessed using the Risk Of Bias In Non-Randomized Studies of Interventions (ROBINS-I) tool.

Results
A total of 7 eligible studies were identified in 8 papers. Government organizations provided the majority of data across studies, with health care providers and third-sector organizations also providing data. Studies used a range of demographic, clinical and health, and administrative data. The purpose of using routinely collected data spanned recruiting and creating a sample, stratification, generating independent variables or covariates, and measuring key study-related outcomes. Nonhome-based modification interventions (eg, in nursing homes) using routinely collected data were not included in this study. We included two protocols, which meant that the results of those studies were not available. MeSH headings were excluded from the PubMed search because of a reduction in specificity. This means that some studies that met the inclusion criteria may not have been identified.

Conclusions
Routine data can be used successfully in many aspects of HAM evaluations and can reduce biases and improve other important design considerations. However, the use of these data in these studies is currently not widespread. There are a number of governance barriers to be overcome to allow these types of linkage and to ensure that the use of routinely collected data in evaluations of HAM interventions is exploited to its full potential.
Performance of the Neonatal Tetanus Surveillance System (NTSS) in Sana'a, Yemen: Evaluation Study
Authors: Al-Jamrah Khaled Mohammed , Al Nabehi Basheer Abdulgalil , Almoayed Khaled Abdullah , Anam Labiba Saeed , Khader Yousef S 
Published: March 2021

Background
The Neonatal Tetanus Surveillance System (NTSS) in Yemen was established in 2009 to identify high-risk areas, determine trends, and evaluate elimination activities. Since its launch, the NTSS had never been evaluated.

Objective
This study aimed to assess the performance of NTSS and determine its strengths and weaknesses to recommend improvements.

Methods
The US Centers for Disease Control and Prevention (CDC) guidelines were used for evaluating the NTSS. Stakeholders at the central, district, and facility levels were interviewed to rate the attributes of the NTSS. The percentage scores for attributes were ranked as poor (<60%), average (≥60% to <80%) and good (≥80%).

Results
The overall usefulness score percentage was 38%, which indicates a poor performance. The performance of the NTSS was rated as average on flexibility (score percent: 68%) and acceptability (score percent: 64%) attributes and poor on stability (score percentage: 33%), simplicity (score percentage: 57%), and representativeness (score percentage: 39%) attributes. About 65% of investigation forms were completed within 48 hours of notification date. Data quality was poor, as 41% of the core variables were missing.

Conclusions
The overall performance of the NTSS was poor. Most of the system attributes require improvement, including stability, simplicity, quality of data, and completeness of investigation. To improve the performance of NTSS, the following are recommended: capacity building of staff (focal points), strengthening NTSS through technical support and government funding to ensure its sustainability, establishing electronic investigation forms for improving the system data quality, and expansion of NTSS coverage to include all private health care facilities.
A Smartphone App for Engaging Patients With Catheter-Associated Urinary Tract Infections: Protocol for an Interrupted Time-Series Analysis
Authors: Bentvelsen Robbert Gerard , Veldkamp Karin Ellen , Chavannes Niels H 
Published: March 2021

Background
Catheter-associated urinary tract infections (CAUTIs) are the main cause of health care–associated infections, and they increase the disease burden, antibiotic usage, and hospital stay. Inappropriate placement and unnecessarily prolonged usage of a catheter lead to an elevated and preventable risk of infection. The smartphone app Participatient has been developed to involve hospitalized patients in communication and decision-making related to catheter use and to control unnecessary (long-term) catheter use to prevent CAUTIs. Sustained behavioral changes for infection prevention can be promoted by empowering patients through Participatient.

Objective
The primary aim of our multicenter prospective interrupted time-series analysis is to reduce inappropriate catheter usage by 15%. We will evaluate the efficacy of Participatient in this quality improvement study in clinical wards. Our secondary endpoints are to reduce CAUTIs and to increase patient satisfaction, involvement, and trust with health care services.

Methods
We will conduct a multicenter interrupted time-series analysis—a strong study design when randomization is not feasible—consisting of a pre- and postintervention point-prevalence survey distributed among participating wards to investigate the efficacy of Participatient in reducing the inappropriate usage of catheters. After customizing Participatient to the wards’ requirements, it will be implemented with a catheter indication checklist among clinical wards in 4 large hospitals in the Netherlands. We will collect clinical data every 2 weeks for 6 months in the pre- and postintervention periods. Simultaneously, we will assess the impact of Participatient on patient satisfaction with health care services and providers and the patients’ perceived involvement in health care through questionnaires, and the barriers and facilitators of eHealth implementation through interviews with health care workers.

Results
To reduce the inappropriate use of approximately 40% of catheters (currently in use) by 15%, we aim to collect 9-12 data points from 70-100 patients per survey date per hospital. Thereafter, we will conduct an interrupted time-series analysis and present the difference between the unadjusted and adjusted rate ratios with a corresponding 95% CI. Differences will be considered significant when P<.05.

Conclusions
Our protocol may help reduce the inappropriate use of catheters and subsequent CAUTIs. By sharing reliable information and daily checklists with hospitalized patients via an app, we aim to provide them a tool to be involved in health care–related decision-making and to increase the quality of care.

Trial Registration
Netherlands Trial Register NL7178; https://www.trialregister.nl/trial/7178

International Registered Report Identifier (IRRID)
DERR1-10.2196/28314
PERENCANAAN STRATEGIS SISTEM INFORMASI UNTUK MENINGKATKAN PERSAINGAN KOMPETITIF
Authors: Kasma Utin 
Published: March 2021

<em>SMU Bina Utama Pontianak merupakan salah satu lembaga pendidikan formal swasta yang ada di kota Pontianak. Dalam pengelolaan operasional sekolah, sebagian besar SMU Bina Utama sudah menerapkan sistem informasi. Namun sistem informasi yang digunakan belum memberikan pengaruh dalam pencapaian persaingan yang kompetitif secara optimal. Hal ini dikarenakan penerapan sistem informasi belum digunakan sebagai tools strategis melainkan hanya mendukung proses pengolahan data administrasi sekolah saja. Dikarenakan semakin bertambahnya SMU Negeri dan swasta yang baru dibuka, untuk itu SMU Bina Utama membutuhkan sebuah perencanaan strategis sistem informasi agar dapat bersaing secara kompetitif dengan SMU negeri maupun swasta yang ada di Pontianak. Framework yang digunakan dalam penelitian ini adalah framework Ward &amp; Peppard. Framework Ward &amp; Peppard dimulai dengan pemahaman situasi saat ini, yaitu lingkungan eksternal dan internal, baik pada lingkungan bisnis maupun pada lingkungan SI/TI</em>. <em>Adapun metode analisis yang digunakan adalah analisis Value Chain, Analisis SWOT, Analisis PEST dan McFarland Strategic Grid. Proses pengumpulan data dilakukan dengan wawancara dengan teknik wawancara personal (Personal interview), observasi dengan pendekatan observasi terstruktur dan studi dokumentasi</em>. <em>Tujuan dari penelitian ini adalah membuat perencanaan strategis sistem informasi pada SMA Bina Utama Pontianak untuk meningkatkan keunggulan kompetitif pada sekolah. </em>