bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polyacrylamide/Copper‐Alginate Double Network Hydrogel Electrolyte with Excellent Mechanical Properties and Strain‐Sensitivity
Authors: Zhang Zeyu , Lin Tingrui , Li Shuangxiao , Chen Xibang , Que Xueyan , Sheng Lang , Hu Yang , Peng Jing , Ma Huiling , Li Jiuqiang , Zhang Wenjuan , Zhai Maolin 
Published: November 2021

AbstractThe double network (DN) hydrogel has attracted great attention due to its wide applications in daily life. However, synthesis DN hydrogel with excellent mechanical properties is still a big challenge. Here, polyacrylamide/copper‐alginate double network (PAM/Cu‐alg DN) hydrogel electrolyte is successfully synthesized by radiation‐induced polymerization and cross‐linking process of acrylamide with N, N’‐methylene‐bis‐acrylamide and subsequent cupric ion (Cu2+) crosslinking of alginate. The content of sodium alginate, absorbed dose, and the concentration of Cu2+ are investigated in detail for improving the overall properties of PAM/Cu‐alg DN hydrogel electrolyte. The PAM/Cu‐alg DN hydrogel electrolyte synthesizes by radiation technique and Cu2+ crosslinking shows superior mechanical properties with a tensile strength of 2.25 ± 0.02 MPa, excellent energy dissipation mechanism, and the high ionic conductivity of 4.08 ± 0.17 mS cm−1. PAM/Cu‐alg DN hydrogel is characterized with attenuated total reflection Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy, and X‐ray photoelectron spectroscopy analyses and the reason for the improvement of mechanical properties is illustrated. Furthermore, PAM/Cu‐alg DN hydrogel electrolyte exhibits excellent strain‐sensitivity, cyclic stability, and durability. This work paves for the new way for the preparation of DN hydrogel electrolytes with excellent properties.
Signs and symptoms, apart from vital signs, that trigger nurses’ concerns about deteriorating conditions in hospitalized paediatric patients: A scoping review
Authors: Jensen Claus Sixtus , Lisby Marianne , Kirkegaard Hans , Loft Mia Ingerslev 
Published: November 2021

AbstractAimThis scoping review aimed to identify and map the signs and symptoms—apart from vital signs—that trigger nurses’ concerns about the deteriorating conditions of hospitalized paediatric patients.DesignA scoping review was conducted in accordance with the Joanna Briggs Institute methodology.MethodsSix databases, including MEDLINE, CINAHL, Embase, Scopus, Swemed and ProQuest Dissertations and Theses databases, were searched systematically. Of 5795 citations, seven matched the inclusion criteria.ResultsObjective observations, such as the patient's colour, pain‐level changes, and behavioural observations, were identified as signs that would trigger nurses’ concerns. Nurse's intuitive feelings or gut feelings when seeing a patient was also identified as an important factor for identifying a deteriorating paediatric patient. A “gut feeling” was described as both a reaction to patient signs and a feeling based on the nurse's intuition gained through experience. The signs or symptoms that would trigger this “gut feeling” were not identified.
In‐plane shear behaviors of unbalanced 3D interlock woven reinforcement in bias extension test: Experiments and finite element modeling
Authors: Guan Liuxiang , Hao Keqian , Mei Shuo , Yang Haizhen , Lu Shiyan , Yang Yanfei 
Published: November 2021

AbstractIn this paper, the in‐plane shear deformation of unbalanced 3D interlock woven reinforcement (IWR) was investigated through experiments and finite element modeling. Five specimens with five layers warp (six layers weft) were designed and prepared. The warp is 792 tex carbon tows and weft is 396 tex carbon tows. This kind of reinforcement is unbalanced because that the linear density of warp is different from that of weft. The in‐plane shear deformation of unbalanced 3D IWR was tested by bias extension test. The bias extension process was simulated by finite element method from macro and meso scales. The results of simulation are basically consistent with experiments. The bias extension process can be divided into three stages: Meso scale deformation stage, multiscale deformation stage and Reinforcement failure stage. At meso scale deformation stage, the tensile load and shear angle are small when the displacement is less than 7.5 mm. There is no obvious change in the macro scale, while the weft slipping in the meso scale mainly occurs in area B. The deformation of B1 and B2 are asymmetric because the linear density of warp is different from that of weft. In the multiscale deformation stage, asymmetric deformation at the macro scale begins to appear when the displacement is between 7.5 mm and 20 mm. There is obvious in‐plane shear deformation in area C at the meso scale. In the reinforcement failure stage, A large number of weft yarns are pulled out from the reinforcement in area B.
Microbial Lipopeptide Supramolecular Self‐Assemblies as a Methuosis‐Like Cell Death Inducer with In Vivo Antitumor Activity
Authors: Lu Jiao Yang , Huang Wei Tao , Zhou Kexuan , Zhao Xiaoli , Yang Shuqing , Xia Liqiu , Ding Xuezhi 
Published: November 2021

AbstractDiscovering new drugs and improving action mechanisms is a promising strategy to overcome chemotherapy ineffectiveness caused by cancer cell apoptosis resistance. Natural products (like cyclic lipopeptides, CLPs) are potential sources of nonapoptotic cell death inducers and can form diverse supramolecular structures, closely relating to their bioactivities. Herein, it is found for the first time that fatty chain is the key to maintain self‐assembled form and antitumor activity of microbial‐derived amphiphilic CLP bacillomycin Lb (B‐Lb). Compared with B‐Lb analogues assemblies without antitumor activity, B‐Lb supramolecular self‐assemblies (including nanomicelles, nanofibers, giant micrometer rods) can be generated in a multilevel and cross‐scale manner and served as a methuosis‐like cell death inducer triggered by cytoplasmic vacuolation through macropinocytosis in MDA‐MB‐231‐Luc and MCF‐7 cells and in vivo tumor‐bearing mice. This study will promote constructing of customized CLP micro‐/nanostructures with multipurposes and functions, and boost designing of new antitumor drugs as nonapoptotic cell death modulators based on structure–activity relationship.
Porous Au–Ag Nanoparticles from Galvanic Replacement Applied as Single‐Particle SERS Probe for Quantitative Monitoring
Authors: Wang Lu , Patskovsky Sergiy , Gauthier‐Soumis Bastien , Meunier Michel 
Published: November 2021

AbstractPlasmonic nanostructures have raised the interest of biomedical applications of surface‐enhanced Raman scattering (SERS). To improve the enhancement and produce sensitive SERS probes, porous Au–Ag alloy nanoparticles (NPs) are synthesized by dealloying Au–Ag alloy NP‐precursors with Au or Ag core in aqueous colloidal environment through galvanic replacement reaction. The novel designed core–shell Au–Ag alloy NP‐precursors facilitate controllable synthesis of porous nanostructure, and dealloying degree during the reaction has significant effect on structural and spectral properties of dealloyed porous NPs. Narrow‐dispersed dealloyed NPs are obtained using NPs of Au/Ag ratio from 10/90 to 40/60 with Au and Ag core to produce solid core@porous shell and porous nanoshells, having rough surface, hollowness, and porosity around 30–60%. The clean nanostructure from colloidal synthesis exhibits a redshifted plasmon peak up to near‐infrared region, and the large accessible surface induces highly localized surface plasmon resonance and generates robust SERS activity. Thus, the porous NPs produce intensely enhanced Raman signal up to 68‐fold higher than 100 nm AuNP enhancement at single‐particle level, and the estimated Raman enhancement around 7800, showing the potential for highly sensitive SERS probes. The single‐particle SERS probes are effectively demonstrated in quantitative monitoring of anticancer drug Doxorubicin release.
Nanoprotection Against Retinal Pigment Epithelium Degeneration via Ferroptosis Inhibition
Authors: Tang Zhimin , Huo Minfeng , Ju Yahan , Dai Xiaochan , Ni Ni , Liu Yan , Gao Huiqin , Zhang Dandan , Sun Hao , Fan Xianqun , Chen Yu , Gu Ping 
Published: November 2021

AbstractLethal oxidative stress and ferrous ion accumulation‐mediated degeneration/death in retinal pigment epithelium (RPE) exert an indispensable impact on retinal degenerative diseases with irreversible visual impairment, especially in age‐related macular degeneration (AMD), but corresponding pathogenesis‐oriented medical intervention remains controversial. In this study, the potent iron‐binding nanoscale Prussian blue analogue KCa[FeIII(CN)6] (CaPB) with high biocompatibility is designed to inhibit RPE death and subsequently photoreceptor cell degeneration. In mice, CaPB effectively prevents RPE degeneration and ultimately fulfills superior therapeutic outcomes upon a single intravitreal injection: significant rescue of retinal structures and visual function. Through high‐throughput RNA sequencing and sophisticated biochemistry evaluations, the findings initially unveil that CaPB nanoparticles protect against RPE degradation by inhibiting ferroptotic cell fate. Together with the facile, large‐scale preparations and in vivo biosafety, it is believed that the synthesized CaPB therapeutic nanoparticles are promising for future clinical treatment of diverse retinal diseases involving pathological iron‐dependent ferroptosis, including AMD.
Macrophages at the Nexus of Mesenchymal Stromal Cell Potency: The Emerging Role of Chemokine Cooperativity
Authors: Galipeau Jacques 
Published: November 2021

Abstract
Pharmacological depletion of macrophages in vivo with liposomal clodronate renders mice unresponsive to adoptive transfer of mesenchymal stromal cells (MSCs) for affecting outcomes of acute inflammatory pathology. This experimental observation identifies host macrophages as necessary in mediating the salutary anti-inflammatory properties of MSCs as a cellular pharmaceutical. This theory is supported by the observation that transfusion of MSCs leads to the prompt phagocytosis of nearly half of lung entrapped MSCs by lung resident macrophages, triggering an interleukin (IL)-10 suppressive efferocytotic response. In addition, non-phagocytosed MSCs with COX2 competency shape the immune milieu by inducing tissue macrophages to express IL-10. Additional experimental evidence identifies MSC-borne IL-6, IDO and TSG-6 as directly involved in macrophage polarization. Along similar lines of functional convergence, implantation of CCL2+ MSCs in the extravascular space where interaction with lung resident perivascular macrophages is not operative, also leads to IL-10 polarization of CCR2+ macrophages within acute injured tissue far removed from MSC depot. Intriguingly, MSC-derived CCL2 on its own is not sufficient to polarize macrophages and requires heterodimerization with MSC-borne CXCL12 to trigger macrophage IL-10 polarization via CCR2, but not CXCR4. Such chemokine cooperativity opens a new venue for analysis of MSC potency especially considering the rich chemokine secretome of MSC exposed to inflammatory stimulus. As an aggregate, these data highlight a necessary MSC and host macrophage functional dyad that may inform potency attribute analysis of MSCs—including the chemokine interactome—that may be directly linked to in vivo clinical anti-inflammatory and regenerative response.
Cancer Stem Cell-Targeted Therapeutic Approaches for Overcoming Trastuzumab Resistance in HER2-Positive Breast Cancer
Authors: Qiu Yan , Yang Libo , Liu Honghong , Luo Xiaobo 
Published: November 2021

Abstract
Application of the anti-HER2 drug trastuzumab has significantly improved the prognosis of patients with the HER2-positive subtype of breast cancer. However, 50% of patients with HER2 amplification relapse due to trastuzumab resistance. Accumulating evidence indicates that breast cancer is driven by a small subset of cancer-initiating cells or breast cancer stem cells (BCSCs), which have the capacity to self-renew and differentiate to regenerate the tumor cell hierarchy. Increasing data suggest that BCSCs are resistant to conventional therapy, including chemotherapy, radiotherapy, and endocrine therapy, which drives distant metastasis and breast cancer relapse. In recent years, the trastuzumab resistance of breast cancer has been closely related to the prevalence of BCSCs. Here, our primary focus is to discuss the role of epithelial-mesenchymal transition (EMT) of BCSCs in the setting of trastuzumab resistance and approaches of reducing or eradicating BCSCs in HER2-positive breast cancer.
A Case for Revisiting Nodal Signaling in Human Pluripotent Stem Cells
Authors: Hayes Kevin , Kim Yun-Kyo , Pera Martin F. 
Published: November 2021

Abstract
Nodal is a transforming growth factor-β (TGF-β) superfamily member that plays a number of critical roles in mammalian embryonic development. Nodal is essential for the support of the peri-implantation epiblast in the mouse embryo and subsequently acts to specify mesendodermal fate at the time of gastrulation and, later, left-right asymmetry. Maintenance of human pluripotent stem cells (hPSCs) in vitro is dependent on Nodal signaling. Because it has proven difficult to prepare a biologically active form of recombinant Nodal protein, Activin or TGFB1 are widely used as surrogates for NODAL in hPSC culture. Nonetheless, the expression of the components of an endogenous Nodal signaling pathway in hPSC provides a potential autocrine pathway for the regulation of self-renewal in this system. Here we review recent studies that have clarified the role of Nodal signaling in pluripotent stem cell populations, highlighted spatial restrictions on Nodal signaling, and shown that Nodal functions in vivo as a heterodimer with GDF3, another TGF-β superfamily member expressed by hPSC. We discuss the role of this pathway in the maintenance of the epiblast and hPSC in light of these new advances.
Chapter 6: Russia’s Regional Free Trade Agreements and Agri-Food Trade After 2014
Authors: Elvestad Christel , Isachenko Tatiana 
Published: November 2021

AbstractThis chapter analyses changes in Russia’s agri-food trade relations after 2014 with a specific focus on regional trade agreements. The introduction of countersanctions against Western countries in 2014 spurred the need to replace some of Russia’s most important foreign food trade partners. Free trade agreements can be effective instruments to boost trade and strengthen ties between countries. Russia is a latecomer in the race for free trade agreements, but a series of agreements have been negotiated since 2015. The portfolio of free trade agreements is still in an early stage, but there is a clear turn to Asia in Russia’s trade. China’s role in total trade as well as in agri-food trade with Russia is considerably strengthened despite the lack of trade preferences so far.
Effective Field Theory for jet substructure in heavy ion collisions
Authors: Vaidya Varun 
Published: November 2021

Abstract
I develop an Effective Field Theory (EFT) framework to compute jet substructure observables for heavy ion collision experiments. As an example, I consider dijet events that accompany the formation of a weakly coupled long lived Quark Gluon Plasma (QGP) medium in a heavy ion collision and look at an observable insensitive to jet selection bias: the simultaneous measurement of jet mass along with the transverse momentum imbalance between the jets that are groomed to remove soft radiation. Treating the jet as an open quantum system, I write down a factorization formula within the SCET (Soft Collinear Effective Theory) framework in the forward scattering regime. The physics of the medium is encoded in a universal soft field correlator while the jet-medium interaction is captured by a medium induced jet function. The factorization formula leads to a Lindblad type equation for the evolution of the reduced density matrix of the jet in the Markovian approximation. The solution for this equation allows a resummation of large logarithms that arise due to the final state measurements imposed while simultaneously summing over multiple incoherent interactions of the jet with the medium.
Single Assessment Numeric Evaluation (SANE) – ein vielversprechendes, valides Messinstrument der „patient-reported outcome measures“ (PROM)
Authors: Örgel Marcus , Graulich Tilman , Liodakis Emmanouil 
Published: November 2021

Zusammenfassung„Patient-reported outcome measures“ (PROM) sind klinische Messinstrumente, die den Gesundheitszustand sowie die Ergebnisse medizinischer Interventionen aus der Perspektive des Patienten erfassen. Ziel dieser Studie war es, retrospektiv die Korrelation zwischen dem Oxford Elbow Score (OES) und Single Assessment Numeric Evaluation (SANE) zu untersuchen. Dies wurde zwischen Dezember 2018 und Februar 2019 bei 86 Patienten mittels des Pearson Korrelationskoeffizient zwischem dem SANE und OES untersucht. OES und die SANE korrelierten signifikant (r = 0,903, p < 0,001), sodass SANE als vielversprechender Outcome-Parameter neben etablierten Scores betrachtet werden kann.
DNS-embedded service endpoint registry for distributed e-Infrastructures
Authors: Salnikov Andrii , Kónya Balázs 
Published: November 2021

AbstractDistributed e-Infrastructure is a key component of modern BIG Science. Service discovery in e-Science environments, such as Worldwide LHC Computing Grid (WLCG), is a crucial functionality that relies on service registry. In this paper we re-formulate the requirements for the service endpoint registry based on our more than 10 years experience with many systems designed or used within the WLCG e-Infrastructure. To satisfy those requirements the paper proposes a novel idea to use the existing well-established Domain Name System (DNS) infrastructure together with a suitable data model as a service endpoint registry. The presented ARC Hierarchical Endpoints Registry (ARCHERY) system consists of a minimalistic data model representing services and their endpoints within e-Infrastructures, a rendering of the data model embedded into DNS-records, a lightweight software layer for DNS-record management and client-side data discovery. Our approach for the ARCHERY registry required minimal software development and inherits all the benefits of one of the most reliable distributed information discovery source of the internet, the DNS infrastructure. In particular, deployment, management and operation of ARCHERY is fully relying on DNS. Results of ARCHERY deployment use-cases are provided together with performance analysis.
Effects of experimental multi-season drought on abundance, richness, and beta diversity patterns in perennially flowing stream insect communities
Authors: Saffarinia P. , Anderson K. E. , Herbst D. B. 
Published: November 2021

AbstractFreshwater systems are projected to experience increased hydrologic extremes under climate change. To determine how small streams may be impacted by shifts in flow regimes, we experimentally simulated flow loss over the span of three summers in nine 50 m naturally fed stream channels. The aquatic insect community of these streams was sampled before, during, and after experimental drought treatments as well as following one unforeseen flood event. Abundance, richness, and beta diversity were measured as indicators of biotic effects of altered flow regimes. Abundance declined in proportion to flow loss. In contrast, we observed a threshold response in richness where richness did not decrease except in channels where losses of surface flow occurred and disconnected pools remained. The flood reset this pattern, but communities continued their prior trajectories shortly thereafter. Beta diversity partitions suggested no strong compositional shifts, and that the effect of drought was largely experienced uniformly across taxa until flow cessation. Pools served as a refuge, maintaining stable abundance gradients and higher richness longer than riffles. Upon flow resumption, abundance and richness returned to pre-treatment levels within one year. Our results suggest that many taxa present were resistant to drought conditions until loss in surface flow occurred.
Green Chemistry Production of Codlemone, the Sex Pheromone of the Codling Moth (Cydia pomonella), by Metabolic Engineering of the Oilseed Crop Camelina (Camelina sativa)
Authors: Xia Yi-Han , Wang Hong-Lei , Ding Bao-Jian , Svensson Glenn P. , Jarl-Sunesson Carin , Cahoon Edgar B. , Hofvander Per , Löfstedt Christer 
Published: November 2021

AbstractSynthetic pheromones have been used for pest control over several decades. The conventional synthesis of di-unsaturated pheromone compounds is usually complex and costly. Camelina (Camelina sativa) has emerged as an ideal, non-food biotech oilseed platform for production of oils with modified fatty acid compositions. We used Camelina as a plant factory to produce mono- and di-unsaturated C12 chain length moth sex pheromone precursors, (E)-9-dodecenoic acid and (E,E)-8,10-dodecadienoic acid, by introducing a fatty acyl-ACP thioesterase FatB gene UcTE from California bay laurel (Umbellularia californica) and a bifunctional ∆9 desaturase gene Cpo_CPRQ from the codling moth, Cydia pomonella. Different transgene combinations were investigated for increasing pheromone precursor yield. The most productive Camelina line was engineered with a vector that contained one copy of UcTE and the viral suppressor protein encoding P19 transgenes and three copies of Cpo_CPRQ transgene. The T2 generation of this line produced 9.4% of (E)-9-dodecenoic acid and 5.5% of (E,E)-8,10-dodecadienoic acid of the total fatty acids, and seeds were selected to advance top-performing lines to homozygosity. In the T4 generation, production levels of (E)-9-dodecenoic acid and (E,E)-8,10-dodecadienoic acid remained stable. The diene acid together with other seed fatty acids were converted into corresponding alcohols, and the bioactivity of the plant-derived codlemone was confirmed by GC-EAD and a flight tunnel assay. Trapping in orchards and home gardens confirmed significant and specific attraction of C. pomonella males to the plant-derived codlemone.
Kanzelhöhe Observatory: Instruments, Data Processing and Data Products
Authors: Pötzi Werner , Veronig Astrid , Jarolim Robert , Rodríguez Gómez Jenny Marcela , Podlachikova Tatiana , Baumgartner Dietmar , Freislich Heinrich , Strutzmann Heinz 
Published: November 2021

AbstractKanzelhöhe Observatory for Solar and Environmental Research (KSO) of the University of Graz (Austria) is in continuous operation since its foundation in 1943. Since the beginning, its main task was the regular observation of the Sun in full disc. In this long time span covering almost seven solar cycles, a substantial amount of data was collected, which is made available online. In this article we describe the separate processing steps from data acquisition to high level products for different observing wavelengths. First of all we present in detail the quality classification, which is important for further processing of the raw images. We show how we construct centre-to-limb variation (CLV) profiles and how we remove large scale intensity variations produced by the telescope optics in order to get images with uniform intensity and contrast. Another important point is an overview of the different data products from raw images to high contrast images with heliographic grids overlaid. As the data products are accessible via different sources, we also present how to get information about the availability and how to obtain these data. Finally, in an appendix, we describe in detail the information in the FITS headers, the file naming and the data hierarchy.