bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tamoxifen: Will Less Equal More in Women with Precancerous Breast Disease?
Authors: Fabian Carol J. 
Published: April 2021

Abstract
Similar risk reduction but fewer side effects would predict more uptake and compliance with low (5 mg) versus full (20 mg) dose tamoxifen. Benefit with low dose is demonstrated for perimenopausal/postmenopausal women with intraepithelial neoplasia and high lesion Ki-67. Longer follow-up needed to determine benefit with low lesion Ki-67.
See related article by DeCensi et al., p. 3576
Association rule hiding using integer linear programming
Authors: B. Suma , G. Shobha 
Published: April 2021

<span>Privacy preserving data mining has become the focus of attention of government statistical agencies and database security research community who are concerned with preventing privacy disclosure during data mining. Repositories of large datasets include sensitive rules that need to be concealed from unauthorized access. Hence, association rule hiding emerged as one of the powerful techniques for hiding sensitive knowledge that exists in data before it is published. In this paper, we present a constraint-based optimization approach for hiding a set of sensitive association rules, using a well-structured integer linear program formulation. The proposed approach reduces the database sanitization problem to an instance of the integer linear programming problem. The solution of the integer linear program determines the transactions that need to be sanitized in order to conceal the sensitive rules while minimizing the impact of sanitization on the non-sensitive rules. We also present a heuristic sanitization algorithm that performs hiding by reducing the support or the confidence of the sensitive rules. The results of the experimental evaluation of the proposed approach on real-life datasets indicate the promising performance of the approach in terms of side effects on the original database.</span>
Robotic hex-nut sorting system with deep learning
Authors: Almanza Cristian , Baquero Javier Martínez , Jiménez-Moreno Robinson 
Published: April 2021

<span>This article exposes the design and implementation of an automation system based on a robotic arm for hex-nut classification, using pattern recognition and image processing. The robotic arm work based on three servo motors and an electromagnetic end effector. The pattern recognition implemented allows classifying three different types of hex-nut through deep learning algorithms based on convolutional neural network architectures. The proposed methodology exposes four phases: the first is the design, implementation, and control of a robotic arm. The second is the capture, classification, and image treatment; the third allows gripping the nut through the robot’s inverse kinematic. The final phase is the re-localization of the hex-nut in the respective container. The automation system successfully classifies all the types of hex-nuts, where the convolutional network used is an efficient and recent pattern recognition method, with an accuracy of 100% in 150 iterations. This development allows for obtaining a novel algorithm for robotic applications in hex-nut sorting.</span>
Soluble CD14 Levels in the Jackson Heart Study: Associations With Cardiovascular Disease Risk and Genetic Variants
Authors: Stanislawski Maggie A. , Lange Leslie A. , Raffield Laura M. , Zakai Neil A. , Meyer Mariah , Ferrier Kendra , Szeto Mindy D. , Leavitt Colton , Shortt Jonathan A. , Thornton Timothy A. , Tracy Russell P. , Auer Paul L. , Reiner Alex P. , Lange Ethan M. , Olson Nels C. 
Published: April 2021

Objective:
sCD14 (soluble CD14) is a circulating pattern recognition receptor involved in inflammatory signaling. Although it is known that sCD14 levels vary by race, information on the genetic and cardiovascular disease (CVD) risk relationships of sCD14 in Black participants is limited.

Approach and Results:

We measured sCD14 in plasma at the baseline exam from n=3492 Black participants from the JHS (Jackson Heart Study). We evaluated associations between sCD14 and subclinical CVD measures, incident CVD events, and mortality under 3 levels of covariate adjustment. We used whole-genome sequence data from the Trans-Omics for Personalized Medicine program to identify genetic associations with sCD14. Adjusting for CVD risk factors and C-reactive protein, higher sCD14 was significantly associated with increased risk of mortality (hazard ratio, 1.25 [95% CI, 1.17–1.32]), incident coronary heart disease (hazard ratio, 1.28 [95% CI, 1.11–1.47]), and incident heart failure (hazard ratio, 1.27 [95% CI, 1.15–1.41]), but not stroke (hazard ratio, 0.96 [95% CI, 0.84–1.09]). Some of these relationships differed by age or sex: the association between sCD14 and heart failure was only observed in females; there was an association between sCD14 and stroke only at younger ages (in the lowest tertile of age, <49.4 years). We replicated the association between sCD14 levels with African ancestry-specific allele (rs75652866) on the
CD14
region of chromosome 5q31. We additionally identified 2 novel statistically distinct genetic associations with sCD14 represented by index variants rs770147646 and rs57599368, also in the chromosome 5q31 region.

Conclusions:
sCD14 independently predicts CVD-related outcomes and mortality in Black participants.
Not So Well Campaign Speech in Swahili
Authors: Kipacha Ahmad 
Published: April 2021

Abstract
The political campaign speeches can be used not only as platform to promote election manifestos of the candidates but also as communication channels imbued with creative manipulation of words, phrases, sayings and proverbial expressions to lure voters. Of interest in this study, is how some erudite public figures in Tanzania tend to interspace their political campaign speeches with proverbial elements. As campaign speeches aim to weaken political rivals, the use of subverted form of standard adage became inevitable on the process of waging verbal war to disarm opponents’ argumentative style, didactic wisdom and explanatory prowess. This paper goes beyond the exploration of standard proverbial expressions in political campaign speeches, to specifically target the deliberate modification, parody, subversion on existing proverbs and proverbial expressions in Swahili by the two major political parties of CCM and UKAWA as contested in the 2015 Tanzania general election campaigns.
“Five and Five Does Not Make Ten …”
Authors: Raji-Oyelade Aderemi , Ango Zaynab 
Published: April 2021

Abstract
The scholarship of change and transformations in proverbs has become an emergent industry in contemporary African studies. The term in transgressive paremiography used for this phenomenon of transformation is called postproverbials. Postproverbiality in Fulfulde is one illustration of the engagement with perspectives of modernities, and aspects of change in worldviews among the Ful’be. “Five and five does not make ten, …” is a signal Ful’be proverbial clause which represents the early interactional history of trade, political and jurisprudent relations between the Ful’be and the predominant Hausa communities of Northern Nigeria. The proverb has experienced a radical reception and turning, based on contemporary social relations and literacy. It is employed in this essay as a symbolic example of how change in proverb construction can also be a challenge to received history. Thirteen pairs of Ful’be proverbs and postproverbials will be deployed to establish the phenomenon of transgressive proverb-making among contemporary Ful’be speakers. The essay will highlight the peculiar forms of extensions, adaptations and cutterage that have been invested into the making of new radical Fulbe proverbs, usually by a younger generation of Fulfulde speakers whose attempt (inadvertent or deliberate) is ultimately to break conventions through newly invented proverbs.
Between Cooperation and/or Co-optation and Confrontation: Civil Society-State Relations in Ethiopia, Since 1991 up to 2018
Authors: Gichamo Bekalu Wachiso , Woldesenbet Wassihun Gebreegizaber 
Published: April 2021

Abstract
By qualitatively drawing on relevant empirical and secondary data sources, the present study sought to investigate the relationship and the practice between the Ethiopian state and csos through the illustration of different relationship patterns, i.e. cooperation and/or co-optation and confrontation, between the two actors and the implications thereof for the imperative of democratization in the country. The study primarily analyzed two supplementary notions: the politico-legal changes in the governance of Ethiopian csos, between 1991 and 2018, on the one hand, and the strategies employed by cso actors to deal with such changes in the same period, on the other hand. The analysis could be further divided into two analytical time periods i.e., the first is from 1991 up to 2005 and the second is from 2005 up to 2018. In doing so, the study found out that the state-civil society relations in Ethiopia since 1991 was more complicated than implied by the liberal discourse, and reflected a continuum of accommodation and confrontation dynamics. The study concluded by arguing that the commonly held dichotomy which polarized the relation between the state and csos as a whole may have overlooked the nature of relationship between the two actors, which can range from overt and hidden tensions and active hostility to cooperation and collaboration, depending on various factors across time and space.
Freedom of Thought in Canada: The History of a Forgetting and the Potential of a Remembering
Authors: Newman Dwight 
Published: April 2021

Abstract
Canada has a constitutional freedom of thought clause that has received almost no attention. This article considers reasons behind this phenomenon and the future potential of the clause. Unlike many constitutional rights and freedoms in Canada, constitutionalised freedom of thought did not have precedents in prior Canadian human rights instruments. Rather, its precedents are in international human rights instruments, with Canadian drafters choosing to adopt this freedom into Canada’s 1982 Charter of Rights and Freedoms. For a complex set of reasons, almost no Canadian case law has developed on freedom of thought. This article explains that phenomenon in terms of path dependence and problematic features of Canadian jurisprudence and scholarship. It argues that some recent cases offer new hope for development of freedom of thought jurisprudence. It argues that comparative constitutional conversations and emerging contemporary challenges may be significant in the development of Canada’s constitutional freedom of thought guarantee.
Bertrand Russell, Fu Tong, and the Emergence of Scientific Secularism in Early 1920s China
Authors: Vrhovski Jan 
Published: April 2021

Abstract
In the May Fourth period (1917–1921), the Chinese intellectual world saw the emergence of various forms of secularism, which culminated around the year 1922, when a nationwide non-religious movement was formed. The Western-educated philosopher Fu Tong influenced and contributed to the discourse on science and religion in the early 1920s, and his philosophy of religion served as a conduit for the introduction of Bertrand Russell’s ideas about religion into Chinese public and intellectual discourses. This article establishes a connection between Fu and the lectures on religious belief that Russell delivered in Peking in January 1921 and documents the transfer of ideas from Russell to Fu’s philosophical writings on religion between 1921 and 1922. In its central analysis, the article focuses on Fu’s philosophy of religion and his theory of scientific secularism, which he developed as a critique of the Marxist-led non-religious movement from 1922 onward. The discussion also sheds light on the network of intellectual connections underlying the emergence of the notion of scientific secularism in 1920s China.
Cardiac implantable electronic device surgery with interruption of warfarin forgoing post-operative bridging therapy in patients with moderate or high thromboembolic risks
Authors: Ng Andrew Kei-Yan , Ng Pauline Yeung , Tam Eva Wai-Ying , Siu Chung-Wah , Fan Katherine 
Published: April 2021

Abstract
Background
For patients taking warfarin and undergoing pacemaker or implantable cardioverter-defibrillator surgery, clinical evidence and guidelines support continuation of warfarin therapy, as opposed to interruption of warfarin therapy with heparin bridging. Interruption of warfarin without post-operative bridging therapy may be a feasible alternative but data is sparse.

Methods
This is a single-arm observational study including adults who had interruption of warfarin therapy without post-operative bridging therapy for cardiac implantable electronic device (CIED) surgery performed between 2010 and 2019 in a tertiary referral hospital. The primary outcome was a composite of all-cause mortality, arterial or venous thromboembolic events. The secondary outcomes were clinically significant device-pocket hematoma and other procedural complications.

Results
Of the 411 patients analysed including 257 patients (62.5%) who had mechanical heart valves, the primary outcome developed in 5 (1.2%) patients within 30 days after surgery, including death in 3 (0.7%) patients, transient ischemic attack in 1 (0.2%) patient and non-CNS embolism in 1 (0.2%) patient. Clinically significant hematomas occurred in 24 (5.8%) patients, including 15 (3.7%) requiring additional interruption of anti-coagulation and 6 (1.5%) requiring clot evacuation. Other procedural complications and bleeding events were rare (< 1%).

Conclusions
Warfarin interruption without post-operative bridging therapy for CIED surgery was associated with low thromboembolic risks and acceptable bleeding risk. Randomized controlled trials are required to formulate an optimal approach to anti-coagulation management.
N6-methyladenosine-dependent signalling in cancer progression and insights into cancer therapies
Authors: Tan Fenghua , Zhao Mengyao , Xiong Fang , Wang Yumin , Zhang Shanshan , Gong Zhaojian , Li Xiayu , He Yi , Shi Lei , Wang Fuyan , Xiang Bo , Zhou Ming , Li Xiaoling , Li Yong , Li Guiyuan , Zeng Zhaoyang , Xiong Wei , Guo Can 
Published: April 2021

AbstractThe N6-methyladenosine (m6A) modification is a dynamic and reversible epigenetic modification, which is co-transcriptionally deposited by a methyltransferase complex, removed by a demethylase, and recognized by reader proteins. Mechanistically, m6A modification regulates the expression levels of mRNA and nocoding RNA by modulating the fate of modified RNA molecules, such as RNA splicing, nuclear transport, translation, and stability. Several studies have shown that m6A modification is dysregulated in the progression of multiple diseases, especially human tumors. We emphasized that the dysregulation of m6A modification affects different signal transduction pathways and involves in the biological processes underlying tumor cell proliferation, apoptosis, invasion and migration, and metabolic reprogramming, and discuss the effects on different cancer treatment.
Radiofrequency ablation and chemotherapy versus chemotherapy alone for locally advanced pancreatic cancer (PELICAN): study protocol for a randomized controlled trial
Authors:   for the Dutch Pancreatic Cancer Group, Walma M. S. , Rombouts S. J. , Brada L. J. H. , Borel Rinkes I. H. , Bosscha K. , Bruijnen R. C. , Busch O. R. , Creemers G. J. , Daams F. , van Dam R. M. , van Delden O. M. , Festen S. , Ghorbani P. , de Groot D. J. , de Groot J. W. B. , Haj Mohammad N. , van Hillegersberg R. , de Hingh I. H. , D’Hondt M. , Kerver E. D. , van Leeuwen M. S. , Liem M. S. , van Lienden K. P. , Los M. , de Meijer V. E. , Meijerink M. R. , Mekenkamp L. J. , Nio C. Y. , Oulad Abdennabi I. , Pando E. , Patijn G. A. , Polée M. B. , Pruijt J. F. , Roeyen G. , Ropela J. A. , Stommel M. W. J. , de Vos-Geelen J. , de Vries J. J. , van der Waal E. M. , Wessels F. J. , Wilmink J. W. , van Santvoort H. C. , Besselink M. G. , Molenaar I. Q. 
Published: April 2021

Abstract
Background
Approximately 80% of patients with locally advanced pancreatic cancer (LAPC) are treated with chemotherapy, of whom approximately 10% undergo a resection. Cohort studies investigating local tumor ablation with radiofrequency ablation (RFA) have reported a promising overall survival of 26–34 months when given in a multimodal setting. However, randomized controlled trials (RCTs) investigating the effect of RFA in combination with chemotherapy in patients with LAPC are lacking.

Methods
The “Pancreatic Locally Advanced Unresectable Cancer Ablation” (PELICAN) trial is an international multicenter superiority RCT, initiated by the Dutch Pancreatic Cancer Group (DPCG). All patients with LAPC according to DPCG criteria, who start with FOLFIRINOX or (nab-paclitaxel/)gemcitabine, are screened for eligibility. Restaging is performed after completion of four cycles of FOLFIRINOX or two cycles of (nab-paclitaxel/)gemcitabine (i.e., 2 months of treatment), and the results are assessed within a nationwide online expert panel. Eligible patients with RECIST stable disease or objective response, in whom resection is not feasible, are randomized to RFA followed by chemotherapy or chemotherapy alone. In total, 228 patients will be included in 16 centers in The Netherlands and four other European centers. The primary endpoint is overall survival. Secondary endpoints include progression-free survival, RECIST response, CA 19.9 and CEA response, toxicity, quality of life, pain, costs, and immunomodulatory effects of RFA.

Discussion
The PELICAN RCT aims to assess whether the combination of chemotherapy and RFA improves the overall survival when compared to chemotherapy alone, in patients with LAPC with no progression of disease following 2 months of systemic treatment.

Trial registration
Dutch Trial RegistryNL4997. Registered on December 29, 2015. ClinicalTrials.govNCT03690323. Retrospectively registered on October 1, 2018
Statistical analysis plan for the Surgery for Cancer with Option of Palliative Care Expert (SCOPE) trial: a randomized controlled trial of a specialist palliative care intervention for patients undergoing surgery for cancer
Authors: Orun Onur M. , Shinall Myrick C. , Hoskins Aimee , Morgan Ellis , Karlekar Mohana , Martin Sara F. , Ely E. Wesley , Raman Rameela 
Published: April 2021

Abstract
Background
The impact of specialist palliative care intervention in patients undergoing surgery for cancer has not been studied extensively. The SCOPE randomized controlled trial will investigate the effect of specialist palliative care intervention in cancer patients undergoing surgery for selected abdominal malignancies. The study protocol of the SCOPE Trial was published in December 2019.

Methods and design
The SCOPE Trial is a single-center, single-blind, prospective, randomized controlled trial that will investigate specialist palliative care intervention for cancer patients undergoing surgery for selected abdominal malignancies. The study plans to enroll 236 patients that will be randomized to specialist palliative care (intervention arm) and usual care (control arm) in a 1:1 ratio.

Results
The primary outcome of the study is the Functional Assessment of Cancer Therapy-General (FACT-G) Trial Outcome Index (TOI) at 90 days postoperatively. Secondary outcomes of the study include the total FACT-G score at 90 days postoperatively, days alive at home without an emergency room visit within 90 days of operation, and all-cause mortality at 1 year after operation. Time frames for all outcomes will start on the day of surgery.

Conclusion
This manuscript serves as the formal statistical analysis plan (version 1.0) for the SCOPE randomized controlled trial. The statistical analysis plan was completed on 6 April 2021.

Trial registration
ClinicalTrials.gov NCT03436290. Registered on 16 February 2018
Structural stability for the Forchheimer equations interfacing with a Darcy fluid in a bounded region in $\mathbb{R}^{3}$
Authors: Shi Jincheng , Liu Yan 
Published: April 2021

AbstractThe structural stability for the Forchheimer fluid interfacing with a Darcy fluid in a bounded region in$\mathbb{R}^{3}$R3was studied. We assumed that the nonlinear fluid was governed by the Forchheimer equations in$\Omega _{1}$Ω1, while in$\Omega _{2}$Ω2, we supposed that the flow satisfies the Darcy equations. With the aid of some useful a priori bounds, we were able to demonstrate the continuous dependence results for the Forchheimer coefficientλ.
Socioeconomic, urban‐rural and sex‐based inequality in infant mortality rate: evidence from 2013 Yemen demographic and health survey
Authors: Zegeye Betregiorgis , Shibre Gebretsadik , Haidar Jemal , Lemma Gorems 
Published: April 2021

Abstract
Background
The occurrence of Infant Mortality Rate (IMR) varied globally with most of the cases coming from developing countries including Yemen. The disparity in IMR in Yemen however, has not been well dealt and therefore we examined the IMR inequality based on the most reliable methodology in order to generate evidence-based information for some program initiatives in Yemen.

Methods
Based on the World Health Organization (WHO) Health Equity Assessment Toolkit (HEAT) software, we analyzed the inequality across the different inequality dimensions in Yemen. The toolkit analyzes data stored in the WHO health equity monitor database. Simple and complex, and absolute and relative measures of inequality were calculated for the four dimensions of inequality (subpopulations) which included wealth, education, sex and residence. We computed a 95 % CI to assess statistical significance.

Results
The analysis included 31, 743 infants. Absolute and relative wealth-driven, education, urban-rural and sex-based inequalities were found in IMR. Higher concentration of IMR was observed among infants from the poorest/poor households (ACI=-4.68, 95 % CI; -6.57, -2.79, R = 1.61, 95 % CI; 1.18, 2.03), rural residents (D = 15.07, 95 % CI; 8.04, 22.09, PAF=-23.57, 95 % CI; -25.47, -21.68), mothers who had no formal education (ACI=-2.16, 95 % CI; -3.79, -0.54) and had male infants (PAF= -3.66, 95 % CI; -4.86, -2.45).

Conclusions
Higher concentration of IMR was observed among male infants from disadvantaged subpopulations such as poorest/poor, uneducated and rural residents. To eliminate the observed inequalities, interventions are needed to target the poorest/poor households, rural residents, mothers with no formal education and male infants.