bluuebunny/crossref_metadata_2025_split huggingface dataset:
Horizontal Rafting Plate for Treatment of the Tibial Plateau Fracture
Authors: Liu Zhong‐yu , Zhang Jin‐li , Zhang Tao , Cao Qing , Zhao Jun‐chao , Li En‐qi , Shen Qi‐jie , Zhao Bao‐cheng , Zheng Yu‐chen , Chen Yang 
Published: May 2021

ObjectiveThis study aimed to investigate the value of a horizontal rafting plate in treating tibial plateau fractures.MethodsThe data of 24 patients in whom a horizontal rafting plate was used to treat a tibial plateau fracture between October 2014 and January 2018 were retrospectively analyzed, including 16 males and 8 females, aged 21–63 years old, with an average of 40 ± 14.68 years. The fractures included 13 in the left knee and 11 in the right knee. The places where the horizontal rafting plate were used included the anterior margin of tibia, anterolateral tibia, and posterolateral tibia. All cases were followed up for 12–24 months, with an average follow‐up of 17.5 ± 5.0 months. At the last follow‐up, the Rasmussen radiological criteria were used to evaluate the effect of fracture reduction and fixation. The knee joint function was evaluated using the Rasmussen functional score. Computed tomography (CT) scanning and three‐dimensional reconstruction were performed preoperatively and postoperatively, with the quality of reduction of the fractured articular surface clarified by the final follow‐up. The flexion and extension abilities of the knee joint were also measured in the postoperative follow‐up.ResultsPreoperative CT scanning showed that the gap of the tibial plateau was 8.00 ± 1.40 (5–24) mm. The heights of the fracture of the articular surface at all three sites during the final follow‐ups were significantly different from the height before the surgery (P < 0.05). The vertical distance between the articular line and the highest point of the articular surface after reduction was 0.17 ± 0.05 mm. Anatomic reductions were obtained in 24 patients. The Rasmussen functional score after surgeries was 27.25 ± 0.94 points. Bony union was achieved in all the patients. According to the Rasmussen radiological criteria, the scores during the last follow‐up were as follows: the total score was 13–18 points, with an average of 16.00 ± 1.72 points; the scores were excellent in 17 cases and good in seven cases. Therefore, 100% of results were excellent or good. No infection or fracture nonunion was found.ConclusionUsing a horizontal plate can be an effective method for treating special types of fractures of the tibial plateau, including the anterior margin and anterolateral and posterolateral tibial plateau, with satisfactory treatment efficacy.
Equity in Public Services: A Systematic Literature Review
Authors: Cepiku Denita , Mastrodascio Marco 
Published: May 2021

AbstractSince the New Administration perspective was introduced by Dwight Waldo, equity has played a key role in public administration and public policy studies. Much research has focused on employment, politics, jurisprudence, voting and many other issues, while neglecting the role of public services. As gross societal inequities in the world still abound, this article aims at mapping the structure of the knowledge on equity in public services as well as the main conceptualizations and determinants of equity. Quantitative (bibliometrix) and qualitative (narrative) analyses are combined in the analysis of 145 articles from 69 journals. The greatest concentration areas and main drivers of equity (i.e., representative bureaucracy, administrative burden, horizontal and vertical decentralization, privatization, co‐production and performance management) are identified. The review contributes to the advancement of social equity in public administration scholarship and practice by improving the conceptual clarity of the term and by mapping the various literature streams.
Vitamin E regulates bovine granulosa cell apoptosis via NRF2‐mediated defence mechanism by activating PI3K/AKT and ERK1/2 signalling pathways
Authors: Wang Meimei , Li Yan , Gao Yanxia , Li Qiufeng , Cao Yufeng , Shen Yizhao , Chen Panliang , Yan Jinling , Li Jianguo 
Published: May 2021

AbstractHigh‐yield dairy cows are usually subject to high‐intensive cell metabolism and produce excessive reactive oxygen species (ROS). Once ROS is beyond the threshold of scavenging ability, it can induce oxidative stress, imperilling the reproductive performance of cows. The study was to investigate the effects of vitamin E (VE) on H2O2‐induced proliferation and apoptosis of bovine granulosa cells and the underlying molecular mechanism. Granulosa cells were pretreated with VE for 24 hr and then treated with H2O2 for 6 hr. The results showed that VE treatment decreased the intracellular ROS levels, increased the MDA content, and improved the antioxidant enzyme activity in a dose‐dependent manner. Furthermore, VE treatment promoted the proliferation and inhibited apoptosis in granulosa cells by up‐regulation of CCND1 and BCL2 levels and down‐regulation of P21, BAX, and CASP3 levels. The cytoprotective effects of VE were attributed to the activation of the NRF2 signalling pathway. Knockdown of the NRF2 impaired the cytoprotective effects of VE on granulosa cells. Besides, the PI3K/AKT and ERK1/2, but not the p38 signalling pathway is involved in the regulation of VE‐mediated cell proliferation and apoptosis. The PI3K/AKT inhibitor LY294002 and ERK1/2 inhibitor SCH772984 inhibited the VE‐induced granulosa cell proliferation and promoted apoptosis, whereas the p38 inhibitor SB203580 had the opposite effects. These results were confirmed by proliferation and apoptosis‐related gene expression at mRNA and protein levels. The results also showed that the PI3K/AKT inhibitor LY294002 and ERK1/2 inhibitor SCH772984 inhibited VE‐induced NRF2, GCLC, GCLM, and HO‐1 expression, whereas the p38 inhibitor SB203580 not. Overall, the results demonstrated that VE‐regulated granulosa cell proliferation and apoptosis via NRF2‐mediated defence system by activating the PI3K/AKT and ERK1/2 signalling pathway.
ORIGINAL SIN, RACISM, AND EPISTEMOLOGIES OF IGNORANCE
Authors: Mulder Jack 
Published: May 2021

AbstractThe purpose of this article is twofold. First, it explores and shows ways in which one important view of racism parallels the Christian doctrine of original sin. Second, it argues that this comparison helps to close the gap between the two main strands of Christian thinking about original sin. Philosophers and theologians are often asked to decide between Augustinian or Irenaean theories of original sin. An epistemology of ignorance, especially as applied in discussions of racism, helps us to see how this dichotomy may be short‐sighted. For virtually no one, in an epistemology of ignorance, matures into being a racist. Nevertheless, as Charles W. Mills famously argues, the epistemology of ignorance he terms the Racial Contract has a historical inception, namely, the period around the beginning of the Transatlantic Slave Trade. I close the article by discussing whether a model of original sin similar to an epistemology of racist ignorance might satisfy the dogmatic constraints of the Catholic tradition.
CONSCIOUSNESS AND MORAL RESPONSIBILITY: SKEPTICAL CHALLENGES AND THEOLOGICAL REFLECTIONS
Authors: Visala Aku Olavi 
Published: May 2021

AbstractSome philosophers and scientists have argued that we humans cannot be held morally responsible for anything. Invoking results of the neurosciences and the cognitive sciences, they argue that humans lack the kind of conscious control and awareness required for moral responsibility. For theological ethics and Christian theology as a whole, moral responsibility is indispensable. I will begin by outlining some empirical results that are invoked in support of moral responsibility skepticism. I will, then, examine the subsequent discussion and the question why conscious awareness is central to moral responsibility. Consciousness contributes to morally relevant control over action in multiple ways. I will briefly examine some accounts of conscious control that are resistant to the skeptical challenge. Although the empirical results might lead us to revise the degree and range of conscious control, there seems to be enough of it to ground many everyday practices of responsibility. I will conclude the article with some theological reflections.
AQUINAS ON SIN, ESSENCE, AND CHANGE: APPLYING THE REASONING ON WOMEN TO EVOLUTION IN AQUINAS
Authors: Loveland Swanstrom Julie 
Published: May 2021

AbstractAberrations and variations within kinds of creatures required explanation to Western medievals, who took the Genesis creation narratives together with Aristotelian species to imply that change was limited to within species; consequently, species were presumed static. Medieval philosophers often explained variation—including “new” kinds like mules—as due to problems in procreation/gestation (following Aristotle) or by sin. I argue that Aquinas's explanation of variation in women, people with disabilities, and mules suggests that Aquinas cannot be taken to entirely reject the possibility of new kinds, and parallels in his explanation of the existence of women and the possible existence of new kinds provides warrant for a re‐evaluation of his understanding of the notion of the natures or essences shared by kinds. Sin—individual or original—is an inadequate explanation for variation, and the argumentative parallels between Aquinas's treatment of women and mules challenge presumptions about what medievals mean by “static kinds” at all, revealing space for evolutionary thought.
Compression Molding and Nickel Molds for Directional Gecko-Inspired Adhesives
Authors: Kerst Capella F. , Cutkosky Mark R. 
Published: May 2021

Abstract
In the fabrication of directional gecko-inspired adhesives, a new capability made possible by the availability of metal molds is hot compression molding. This molding process allows the use of elastomers with much higher toughness than those cast at ambient temperature and pressure, as has been the common case in fabricating adhesives. In addition, it permits fast cycle times (minutes instead of hours), which is useful for volume manufacturing. We present the results of hot compression molding of elastomers in metal molds created with overhanging and tapered microscopic surface features, which give rise to anisotropic adhesion. We show that the adhesive performance so obtained is equivalent to that obtained earlier with polydimethylsiloxane (PDMS).
Message Passing Interface Parallelization for Two-Way Coupled Euler–Lagrange Simulation of Microbubble Enhanced HIFU
Authors: Ma Jingsen , Gnanaskandan Aswin , Hsiao Chao-Tsung , Chahine Georges L. 
Published: May 2021

Abstract
Microbubble enhanced high intensity focused ultrasound (HIFU) is of great interest to tissue ablation for tumor treatment such as in liver and brain cancers. To accurately characterize the acoustic and thermal fields during this process, a coupled Euler–Lagrange model is used. The ultrasound field is modeled using compressible Navier–Stokes equations on an Eulerian grid, while the microbubbles are tracked in a Lagrangian fashion. The coupling is realized through the void fraction computed from the instantaneous bubble volumes. To speed up the computations, an message passing interface parallelization scheme based on domain decomposition is herein proposed. During each time-step, message passing interface processors, each handling one subdomain, are first used to execute the fluid computation, and then the bubble computations. This is followed by the coupling procedure. The coupling is challenging as the effect of the bubbles through the void fraction at an Eulerian point near a subdomain border will require information from bubbles located in different subdomains, and vice versa. This is addressed by a special utilization of ghost cells surrounding each fluid subdomain, which allows bubbles to spread their void fraction effects across subdomain edges without the need of exchanging directly bubble information between subdomains and significantly increasing overhead. After a careful verification of gas effects conservation, this parallelization scheme is validated and illustrated on a typical microbubble enhanced HIFU problem, followed by parallelization scaling tests and efficiency analysis.
Machine-learning model derived gene signature predictive of paclitaxel survival benefit in gastric cancer: results from the randomised phase III SAMIT trial
Authors: Sundar Raghav , Barr Kumarakulasinghe Nesaretnam , Huak Chan Yiong , Yoshida Kazuhiro , Yoshikawa Takaki , Miyagi Yohei , Rino Yasushi , Masuda Munetaka , Guan Jia , Sakamoto Junichi , Tanaka Shiro , Tan Angie Lay-Keng , Hoppe Michal Marek , Jeyasekharan Anand D. , Ng Cedric Chuan Young , De Simone Mark , Grabsch Heike I. , Lee Jeeyun , Oshima Takashi , Tsuburaya Akira , Tan Patrick 
Published: May 2021

ObjectiveTo date, there are no predictive biomarkers to guide selection of patients with gastric cancer (GC) who benefit from paclitaxel. Stomach cancer Adjuvant Multi-Institutional group Trial (SAMIT) was a 2×2 factorial randomised phase III study in which patients with GC were randomised to Pac-S-1 (paclitaxel +S-1), Pac-UFT (paclitaxel +UFT), S-1 alone or UFT alone after curative surgery.DesignThe primary objective of this study was to identify a gene signature that predicts survival benefit from paclitaxel chemotherapy in GC patients. SAMIT GC samples were profiled using a customised 476 gene NanoString panel. A random forest machine-learning model was applied on the NanoString profiles to develop a gene signature. An independent cohort of metastatic patients with GC treated with paclitaxel and ramucirumab (Pac-Ram) served as an external validation cohort.ResultsFrom the SAMIT trial 499 samples were analysed in this study. From the Pac-S-1 training cohort, the random forest model generated a 19-gene signature assigning patients to two groups: Pac-Sensitive and Pac-Resistant. In the Pac-UFT validation cohort, Pac-Sensitive patients exhibited a significant improvement in disease free survival (DFS): 3-year DFS 66% vs 40% (HR 0.44, p=0.0029). There was no survival difference between Pac-Sensitive and Pac-Resistant in the UFT or S-1 alone arms, test of interaction p<0.001. In the external Pac-Ram validation cohort, the signature predicted benefit for Pac-Sensitive (median PFS 147 days vs 112 days, HR 0.48, p=0.022).ConclusionUsing machine-learning techniques on one of the largest GC trials (SAMIT), we identify a gene signature representing the first predictive biomarker for paclitaxel benefit.Trial registration numberUMIN Clinical Trials Registry: C000000082 (SAMIT); ClinicalTrials.gov identifier, 02628951 (South Korean trial)
Association between parents’ socioeconomic conditions and nutritional status during childhood and the risk of cardiovascular disease in their adult offspring: an intergenerational study in south India
Authors: Mallinson Poppy Alice Carson , Kulkarni Bharati , Bhogadi Santhi , Kinra Sanjay 
Published: May 2021

BackgroundSome researchers have suggested that parents’ exposure to poor socioeconomic conditions during childhood can increase their offspring’s risk of cardiovascular disease, primarily through poor maternal nutrition and growth. However, epidemiological data on this association are limited. In an intergenerational cohort from rural India, we examined the association of parental childhood socioeconomic conditions and stature with offspring’s cardiovascular risk, hypothesising an inverse association between the two.MethodsWe analysed data on 3175 adult offspring (aged 18–35 years, 58% men) and their parents from the third wave of the Andhra Pradesh Children and Parents’ Study (2010–12). We used multilevel linear regression to estimate the association of parents’ Standard of Living Index (SLI, an asset-based measure of socioeconomic conditions) in childhood, height and leg length with subclinical atherosclerosis and cardiovascular risk factors in their offspring.ResultsIn multivariable models adjusted for offspring’s socioeconomic conditions in childhood and adulthood, associations (beta coefficients and 95% CIs) of mother’s and father’s childhood SLI (per SD) were −0.00 mm (−0.01, 0.01) and 0.01 mm (−0.00, 0.02) for carotid intima media thickness, −0.17 mm Hg (−0.61, 0.27) and −0.30 mm Hg (−0.78, 0.20) for systolic blood pressure, −0.43 mg/dL (−2.00, 1.15) and −1.07 mg/dL (−2.79, 0.65) for total cholesterol and −0.00mU/L (−0.04, 0.03) and 0.01mU/L (−0.03, 0.04) for log fasting insulin. Results were of similar magnitude for parental height and leg length.ConclusionsOur findings do not support an inverse association between parental childhood socioeconomic conditions or stature and offspring’s risk of cardiovascular disease. Intergenerational socioeconomic influences on cardiovascular risk may be of limited public health significance for this setting.
Effects of chronic intermittent hypobaric hypoxia on prostate-specific antigen (PSA) in Chilean miners
Authors: Alcantara-Zapata Diana Elizabeth , Bangdiwala Shrikant I , Jiménez Daniel , Kogevinas Manolis , Marchetti Nella , Nazzal Carolina 
Published: May 2021

ObjectiveThe aim was to determine the effects of chronic intermittent hypobaric hypoxia (CIHH) on prostate-specific antigen (PSA) levels in Chilean miners who work at different altitudes.MethodsA cross-sectional study was conducted between April and July 2019. Miners from five mines (N=338) at different altitudes were evaluated. We recorded sociodemographic, working and altitude information. Haemoglobin oxygen saturation (SaO2) and haemoglobin (Hb) were measured in situ, while PSA and testosterone were analysed at a low level. Linear mixed-effect models were used to evaluate the association between PSA level and two CIHH exposures: composite CIHH (with four descriptors) and ChileStd-CIHH (CIHH Chilean standard; based on the Chilean technical guide for occupational exposure to CIHH). All models were adjusted by age, body mass index and day of the work the samples were taken.ResultsHighest and lowest PSA levels were found in mines ≥3000 m above sea level (mine 3: median=0.75, IQR=−0.45; mine 4: median=0.46, IQR=−0.35). In the multilevel models, the wider altitude difference between mining operation and camp showed lower PSA levels (model D: βPSA=−0.93 ng/mL, βlogPSA=−0.07, p<0001), adjusted for other CIHH descriptors, SaO2, Hb and testosterone. The descriptors of composite CIHH explained better PSA variations than ChileStd-CIHH (model D: marginal R2=0.090 vs model A: marginal R2=0.016).ConclusionsOccupational health regulations and high altitude medicine should consider these results as initial evidence on the inclusion of new descriptors for CIHH and the possible effect of this exposure on PSA levels in this male-dominated occupational sector.
Environmental Impacts and Public Opinion About International Trade: Experimental Evidence from Six OECD Countries
Authors: Nguyen Quynh , Huber Robert A. , Bernauer Thomas 
Published: May 2021

Abstract
Do environmental implications of international trade influence public support for economic globalization? And under what conditions do environmental considerations shape individuals’ trade attitudes and policy preferences? In this study, we examine the microfoundations of the trade–environment nexus based on survey-embedded experiments in six OECD countries. Our empirical findings demonstrate that environmental implications have a substantial causal effect on public opinion about international trade. Furthermore, our results indicate that citizens are similarly sensitive to both domestic and international environmental implications of trade. These findings suggest that there is probably sufficient public support for green economy policies that take into account the global rather than only national environmental impacts from trade when designing trade policies.
How Lives Form Leaders: Plutarch’s Tripartite Theory of Leadership Education
Authors: Promisel Michael E. 
Published: May 2021

Abstract
Plutarch’s Parallel Lives was once considered a preeminent source of ethical and leadership instruction. But despite generations turning to the Lives for leadership education, we lack clarity concerning how the Lives cultivate leadership. In fact, Plutarch offers the key to this puzzle in a tripartite theory of leadership education evident throughout his corpus. Leaders should be educated through: 1) philosophical instruction, 2) experience in public life, or 3) literary synthesis – and, ideally, some combination of all three. Plutarch’s Lives, this article contends, exemplifies the third form of education, literary synthesis, which exhibits the influence of philosophical principle and moral character on political conduct. Understanding the Lives as a model of literary leadership education reveals the conditions for written works to cultivate virtuous leaders – the closing consideration of this article.
Characteristics of newly diagnosed HIV-positive service users using a pan-London e-sexually transmitted infection screening service
Authors: Day Sara , Khan Kaywaan , Kelly Adrian M , Jones Sophie , Kinsella Ryan 
Published: May 2021

Maximising opportunities and removing barriers to HIV testing can help reduce the undiagnosed HIV population. Digital STI/HIV screening services have increased in availability and can improve access and testing coverage. We identified the characteristics of individuals who tested HIV positive using a regional, integrated, self-sampling STI service. The e-notes of service users with reactive HIV screening results were reviewed. Between 8 January 2018 and 31 December 2019, 0.097% (144/148,257) users received a reactive HIV result, 30/144 (20.8%) of whom had previously diagnosed HIV infection. All of the remaining 114 users were notified of their screening result, an estimated 109/114 (95.6%) received confirmatory testing (CT) at a sexual health clinic (SHC) and the confirmatory outcome was documented in 102/114 (89.5%) of cases: 34/114 (29.8%)were HIV positive, 68/114 (59.6%) HIV were negative and the result was unknown in 12/114 (10.5%). All new diagnoses transitioned to HIV outpatient care. These individuals were median age 28 years; 94.1% (32/34) male; 88.2% (30/34) men who have sex with men and 11.8% (4/34) heterosexual; 58.8% (20/34) of white/‘white other’ ethnicity and 42.2% of Black, Asian and minority ethnic group; 50%(17/34) had a concurrent STI; 9% and 21% had never tested for HIV or attended a SHC before. n HIV test reactivity rate of 0.1%(95% CI) was observed. Confirmed new HIV diagnoses comprised 0.023% of all HIV tests performed. All individuals where CT confirmed a new HIV diagnosis transitioned to HIV specialist care.