bluuebunny/crossref_metadata_2025_split huggingface dataset:
Position statement on classification of basal cell carcinomas. Part 2: EADO proposal for new operational staging system adapted to basal cell carcinomas
Authors: Grob J.J. , Gaudy‐Marqueste C. , Guminski A. , Malvehy J. , Basset‐seguin N. , Bertrand B. , Fernandez‐Penas P. , Kaufmann R. , Zalaudek I. , Fargnoli M.C. , Tagliaferri L. , Fertil B. , Del Marmol V. , Stratigos A. , Garbe C. , Peris K. 
Published: August 2021

AbstractBackgroundNo simple staging system has emerged for basal cell carcinomas (BCCs), since they do not follow the TNM process, and practitioners failed to agree on simple clinical or pathological criteria as a basis for a classification. Operational classification of BCCs is required for decision‐making, trials and guidelines. Unsupervised clustering of real cases of difficult‐to‐treat BCCs (DTT‐BCCs; part 1) has demonstrated that experts could blindly agree on a five groups classification of DTT‐BCCs based on five patterns of clinical situations.ObjectiveUsing this five patterns to generate an operational and comprehensive classification of BCCs.MethodTesting practitioner's agreement, when using the five patterns classification to ensure that it is robust enough to be used in the practice. Generating the first version of a staging system of BCCs based on pattern recognition.ResultsSixty‐two physicians, including 48 practitioners and the 14 experts who participated in the generation of the five different patterns of DTT‐BCCs, agreed on 90% of cases when classifying 199 DTT‐BCCs cases using the five patterns classification (part 1) attesting that this classification is understandable and usable in practice. In order to cover the whole field of BCCs, these five groups of DTT‐BCCs were added a group representing the huge number of easy‐to‐treat BCCs, for which sub‐classification has little interest, and a group of very rare metastatic cases, resulting in a four‐stage and seven‐substage staging system of BCCs.ConclusionA practical classification adapted to the specificities of BCCs is proposed. It is the first tumour classification based on pattern recognition of clinical situations, which proves to be consistent and usable. This EADO staging system version 1 will be improved step by step and tested as a decision tool and a prognostic instrument.
Effect of repeated heating and cooling cycles on the degree of conversion and microhardness of four resin composites
Authors: Gebril Mohamed , Grüll Marc P. , Brillant Martha Smith , Sullivan Braden , Price Richard B. 
Published: August 2021

AbstractObjectiveThis study evaluated the effect of repeatedly heating and cooling four resin‐based composites (RBCs) for up to six cycles.Materials and MethodsFour commercial RBCs were heated to 68°C and cooled to room temperature for up to six cycles before photocuring at 30°C. Specimens spent a total of 0, 30, 60, 90, 120, 150 min, or 7 days at 68°C. The degree of conversion (DC) was measured at the bottom of the specimens immediately after photocuring. The Vickers microhardness was measured at the top and bottom of the RBC surfaces 24 h after photocuring. The data were analyzed using one‐way analysis of variance, Dunnett's or Bonferroni post‐hoc tests, and Spearman correlation analysis (α = 0.05).ResultsFor two brands of RBC, the DC decreased at various time points; however, these decreases were small, and there was no correlation (negative or positive) between the number of heating cycles and the DC for any of the RBCs. Repeated heated and cooling resulted in small changes in the hardness (compared to the control) in both directions (Dunnett; p < 0.05). Two of the RBCs showed a significant, positive correlation between the number of heating cycles and their hardness at the bottom surface.ConclusionRepeated heating, cooling, and then reheating the RBCs for up to 1 week had little overall effect on their DC and microhardness values. The 2 mm thick specimens of all four RBCs achieved a bottom: top hardness ratio exceeding 0.8 after a 20 s exposure to light from a commercial LED curing lightClinical SignificanceSix repeated dry heating and cooling cycles of up to 1 week in duration had little effect on the DC and the microhardness of four commercial resin‐based composites.
Ultrastructural insights into the replication cycle of salmon pancreas disease virus (SPDV) using salmon cardiac primary cultures (SCPCs)
Authors: Noguera Patricia , Klinger Matthias , Örün Histro , Grunow Bianka , del‐Pozo Jorge 
Published: August 2021

AbstractSalmon pancreas disease virus (SPDV) has been affecting the salmon farming industry for over 30 years, but despite the substantial amount of studies, there are still a number of recognized knowledge gaps, for example in the transmission of the virus. In this work, an ultrastructural morphological approach was used to describe observations after infection by SPDV of an ex vivo cardiac model generated from Atlantic salmon embryos. The observations in this study and those available on previous ultrastructural work on SPDV are compared and contrasted with the current knowledge on terrestrial mammalian and insect alphaviral replication cycles, which is deeper than that of SPDV both morphologically and mechanistically. Despite their limitations, morphological descriptions remain an excellent way to generate novel hypotheses, and this has been the aim of this work. This study has used a target host, ex vivo model and resulted in some previously undescribed features, including filopodial membrane projections, cytoplasmic stress granules or putative intracytoplasmic budding. The latter suggests a new hypothesis that warrants further mechanistic research: SPDV in salmon may have retained the capacity for non‐cytolytic (persistent) infections by intracellular budding, similar to that noted in arthropod vectors of other alphaviruses. In the notable absence of a known intermediate host for SPDV, the presence of this pattern suggests that both cytopathic and persistent infections may coexist in the same host. It is our hope that the ultrastructural comparison presented here stimulates new research that brings the knowledge on SPDV replication cycle up to a similar level to that of terrestrial alphaviruses.
Elevated levels of circulating mitochondrial DNA predict early allograft dysfunction in patients following liver transplantation
Authors: Yoshino Osamu , Wong Boris Ka Leong , Cox Daniel R A , Lee Eunice , Hepworth Graham , Christophi Christopher , Jones Robert , Dobrovic Alexander , Muralidharan Vijayaragavan , Perini Marcos V 
Published: August 2021

AbstractBackground and AimThe role of circulating mitochondrial DNA (cmtDNA) in transplantation remains to be elucidated. cmtDNA may be released into the circulation as a consequence of liver injury; yet recent work also suggests a causative role for cmtDNA leading to hepatocellular injury. We hypothesized that elevated cmtDNA would be associated with adverse events after liver transplantation (LT) and conducted an observational cohort study.MethodsTwenty‐one patients were enrolled prospectively prior to LT.ResultsPostoperative complications were observed in 47.6% (n = 10). Seven patients (33.3%) had early allograft dysfunction (EAD), and six patients (28.5%) experienced acute cellular rejection within 6 months of LT. cmtDNA levels were significantly elevated in all recipients after LT compared with healthy controls and preoperative samples (1 361 937 copies/mL [IQR 586 781–3 399 687] after LT; 545 531 copies/mL [IQR 238 562–1 381 015] before LT; and 194 562 copies/mL [IQR 182 359–231 515] in healthy controls) and returned to normal levels by 5 days after transplantation. cmtDNA levels were particularly elevated in those who developed EAD in the early postoperative period (P < 0.001). In all patients, there was initially a strong overall positive correlation between cmtDNA and plasma hepatocellular enzyme levels (P < 0.05). However, the patients with EAD demonstrated a second peak in cmtDNA at postoperative day 7, which did not correlate with liver function tests.ConclusionsThe early release of plasma cmtDNA is strongly associated with hepatocellular damage; however, the late surge in cmtDNA in patients with EAD appeared to be independent of hepatocellular injury as measured by conventional tests.
Accounting for colonial complicities throughRefusalsin researching agency across borders
Authors: Coultas Clare 
Published: August 2021

AbstractEve Tuck and K. Wayne Yang develop the concept of “refusal” as an essential methodology for decolonizing social sciences, that I suggest provides an opening for white scholars to contribute to decolonizing projects. In this article, I reflect on my attempts at engaging with my colonial complicities, as a white European woman doing research on comprehensive sexuality education and young people's agency in Tanzania. I present this discussion as a series of refusals interspersed throughout more conceptual discussions on how feminist and social psychological theorizing, and post‐/de‐colonial problematizations of it, have advanced my understanding of agency, and shaped my approach and research design. In drawing these literatures together, along with my own practical efforts at applying them, I attempt to mark out, but also problematize, potentials for white people's anti‐colonial praxis in working across borders. I conclude with some broad thoughts on the particularities of refusals connected to whiteness and the neoliberal university.
New paradigms in cell adaptation: decades of discoveries on the CrRLK1L receptor kinase signalling network
Authors: Zhu Sirui , Fu Qiong , Xu Fan , Zheng Heping , Yu Feng 
Published: August 2021

SummaryReceptor‐like kinases (RLKs), which constitute the largest receptor family in plants, are essential for perceiving and relaying information about various environmental stimuli. Tremendous progress has been made in the past few decades towards elucidating the mechanisms of action of several RLKs, with emerging paradigms pointing to their roles in cell adaptations. Among these paradigms, Catharanthus roseus receptor‐like kinase 1‐like (CrRLK1L) proteins and their rapid alkalinization factor (RALF) peptide ligands have attracted much interest. In particular, FERONIA (FER) is a CrRLK1L protein that participates in a wide array of physiological processes associated with RALF signalling, including cell growth and monitoring cell wall integrity, RNA and energy metabolism, and phytohormone and stress responses. Here, we analyse FER in the context of CrRLK1L members and their ligands in multiple species. The FER working model raises many questions about the role of CrRLK1L signalling networks during cell adaptation. For example, how do CrRLK1Ls recognize various RALF peptides from different organisms to initiate specific phosphorylation signal cascades? How do RALF‐FER complexes achieve their specific, sometimes opposite, functions in different cell types? Here, we summarize recent major findings and highlight future perspectives in the field of CrRLK1L signalling networks.
Reframing nothingness in the kunju adaptation of Eugène Ionesco’s The Chairs
Authors: Feng Wei 
Published: August 2021

AbstractPractitioners of xiqu (traditional Chinese theater) have long appropriated Western plays and theatrical ideas to modernize Chinese tradition for new theatricalities. Primarily, plays driven by plot and characterization have been selected to highlight themes germane to Enlightenment modernity. Yet recently, there have been a few intercultural attempts to adapt the so‐called Absurdist drama with xiqu, in a deliberate deviation from metanarratives that have characterized modern Chinese theater for nearly a century, to reflect better the existential conditions of contemporary individuals. By investigating the actors’ reframing of nothingness in Shanghai Kunqu Opera Troupe’s adaptation of Eugène Ionesco’s The Chairs, this article argues that Ionesco’s original absence‐presence dynamic has been displaced and transformed in the Chinese context; his concern with frightening nothingness is replaced by kunju’s philosophical reflection on emptiness, which aims at a positive negativity. This adaptation also suggests a new path for Western modernist plays to communicate with classical Chinese culture.
Becoming part of an upwards spiral: Meanings of being person‐centred in nursing homes
Authors: Lood Qarin , Kirkevold Marit , Edvardsson David 
Published: August 2021

AbstractIntroductionPrevious research suggests that person‐centred care is positive for people living in nursing homes, but less is known on what motivates people working in nursing homes to be person‐centred. Previous research has focused on person‐centred care in relation to people in need of care, which may lead to a risk of viewing person‐centred care as a means to achieve quality of care, and not as a means in itself. Therefore, this study aimed to illuminate meanings of being person‐centred as narrated by people working in nursing homes.MethodsA total of 23 persons working in a nursing home in rural Australia participated in group and individual interviews, conducted and interpreted in respect to a phenomenological hermeneutic approach.ResultsThe thematic structure as emerging from structural analyses of the text indicated that being person‐centred involved a joint effort to think differently on what you do and why you do it interpreted as; Doing what you know and feel is the right thing to do, Being a person with and for another person, and Striving to do and be better together. The comprehensive understanding of these findings was that being person‐centred means becoming part of an upwards spiral of doing person‐centred actions and being person‐centred to become even more person‐centred and to feel a sense of belonging to a person‐centred culture.ConclusionsDenoting the importance of being more of a person in one's professional role, this study highlights health aspects of being person‐centred from the perspective of people working in nursing homes, and complements previous research that describes the impact of person‐centred care on people in need of care. The findings could be applied to facilitate person‐centred care in nursing home contexts, and to develop prevention strategies to diminish negative impacts on person‐centred doing, being, becoming and belonging.
Femoroacetabular Impingement and Labral Tear: From the Most Highly Cited Articles to Research Interests
Authors: Tang Ning , Zhang Wenchao , Su Yang , Han Zhencan , Deng Lingwen , Li Yusheng , Huang Tianlong , Li Chunbao 
Published: August 2021

ObjectiveTo highlight the characteristics of the most highly cited articles and propose the research interests over the past decades in the field of femoroacetabular impingement (FAI) and labral tear.MethodsThe ISI Web of Science database (Clarivate Analytics, New York, the United States) was utilized for the identification of articles on 15 December 2020. FAI and labral tear‐related articles (1138 articles) were retrieved, of which the 100 most‐cited articles (top 100) were identified. Subsequent analysis included citation density (citations/article age), authorship, institution, journal, geographic distribution, level of evidence, and theme.ResultsThe number of citations per article ranged from 66 to 1189 with a mean of 163.31. The majority of articles were published in the United States (all articles/top 100 = 655/57) and Switzerland (85/22). University of Bern (n = 10) was the most prolific institution. The journal with the most of articles was Arthroscopy: The Journal of Arthroscopic and Related Surgery. The most prolific coauthor (all articles) or first authors (top 100) was Domb (n = 109) and Philippon (n = 6), respectively. The evidence with the most articles is level IV (n = 41). The top three most popular topics of research article were outcomes of surgery (n = 23), imaging diagnosis (n = 18), and comparison of surgery (n = 8). The top four most prevalent themes of review were labral tears (n = 3), FAI (n = 3), comparison of surgery imaging diagnosis, and outcomes of surgery (both n = 2). Six keywords with the newest average publication year, including FAI syndrome (average publication year = 2019.50), patient‐reported outcomes (2019.43), femoroplasty (2018.60), clinical outcomes (2018.17), borderline dysplasia (2018.00), and capsule (2018.00). Five keywords with the highest average citations, including outcome (average citations = 88.50), alpha angle (58.00), complications (55.86), revision hip arthroscopy (49.00), and systematic review (46.14).ConclusionsOutcomes research is the most popular research interest and patient‐reported outcome instruments might be further and widely used in the emerging articles in the near future. The field of FAI and labral tear has shown an obvious trend of development and is steadily evolving. It could be predicted that there will be an increasing number of publications in the following years, with the United States and Switzerland maintaining leadership in this field.
Plastic response to early shade avoidance cues has season‐long effect on Beta vulgaris growth and development
Authors: Adjesiwor Albert T. , Ballenger Joseph G. , Weinig Cynthia , Ewers Brent E. , Kniss Andrew R. 
Published: August 2021

AbstractEarly‐emerging weeds are known to negatively affect crop growth but the mechanisms by which weeds reduce crop yield are not fully understood. In a 4‐year study, we evaluated the effect of duration of weed‐reflected light on sugar beet (Beta vulgaris L.) growth and development. The study included an early‐season weed removal series and a late‐season weed addition series of treatments arranged in a randomized complete block, and the study design minimized direct resource competition. If weeds were present from emergence until the two true‐leaf sugar beet stage, sugar beet leaf area was reduced 22%, leaf biomass reduced 25%, and root biomass reduced 32% compared to sugar beet grown season‐long without surrounding weeds. Leaf area, leaf biomass, and root biomass was similar whether weeds were removed at the two true‐leaf stage (approximately 330 GDD after planting) or allowed to remain until sugar beet harvest (approximately 1,240 GDD after planting). Adding weeds at the two true‐leaf stage and leaving them until harvest (~1,240 GDD) reduced sugar beet leaf and root biomass by 18% and 23%, respectively. This work suggests sugar beet responds early and near‐irreversibly to weed presence and has implications for crop management genetic improvement.
RETRACTED: Current trends in the formation and development of insurance marketing in Ukraine
Authors: Kniazieva Tetiana V. , Shevchenko Anna V. , Shevchenko Anna V. , Yaroshenko Oleg M. , Inshyn Mykola I. , Yakovlyev Oleksandr A. 
Published: August 2021

AbstractThe relevance of the article due to the fact that the insurance industry of Ukraine at the present stage is developing in the global financial, economic and CORONA crisis, which deepens a number of unresolved problems: increases the risk of insurance companies, reduces demand for insurance products; distrust of insurance on the part of potential insurers has increased, increasing competition between insurers for the sphere of influence and customers. The purpose of the articles is to prepare theoretical foundations and develop practical recommendations for the introduction and improvement of the use of modern insurance management in the activities of Ukrainian insurers. The result of this studying is deepening and improvement of modern theory in insurance marketing, and development of practical recommendations for improving the efficiency and competitiveness of Ukrainian insurers.
Current advances in transfusion medicine 2020: A critical review of selected topics by the AABB Clinical Transfusion Medicine Committee
Authors: Allen Elizabeth S. , Cohn Claudia S. , Bakhtary Sara , Dunbar Nancy M. , Gniadek Thomas , Hopkins Courtney K. , Jacobson Jessica , Lokhandwala Parvez M. , Metcalf Ryan A. , Murphy Colin , Prochaska Micah T. , Raval Jay S. , Shan Hua , Storch Emily K. , Pagano Monica B. 
Published: August 2021

AbstractBackgroundThe AABB Clinical Transfusion Medicine Committee (CTMC) compiles an annual synopsis of the published literature covering important developments in the field of transfusion medicine (TM), which has been made available as a manuscript published in Transfusion since 2018.MethodsCTMC committee members reviewed original manuscripts including TM‐related topics published electronically (ahead) or in print from December 2019 to December 2020. The selection of topics and manuscripts was discussed at committee meetings and chosen based on relevance and originality. Next, committee members worked in pairs to create a synopsis of each topic, which was then reviewed by two additional committee members. The first and senior authors of this manuscript assembled the final manuscript. Although this synopsis is extensive, it is not exhaustive, and some papers may have been excluded or missed.ResultsThe following topics are included: COVID‐19 effects on the blood supply and regulatory landscape, COVID convalescent plasma, adult transfusion practices, whole blood, molecular immunohematology, pediatric TM, cellular therapy, and apheresis medicine.ConclusionsThis synopsis provides easy access to relevant topics and may be useful as an educational tool.
Effects of monetary policy shocks on exchange rate in emerging countries
Authors: Kim Soyoung , Lim Kuntae 
Published: August 2021

AbstractThis study empirically investigates the effects of monetary policy shocks on the exchange rate in six emerging countries (Korea, Thailand, the Philippines, Mexico, Brazil and Colombia). VAR models are used, wherein sign restrictions on impulse responses are imposed to identify monetary policy shocks. The empirical model reflects the small open emerging economy features. The estimation period is the recent period in which these countries adopted inflation‐targeting and more flexible exchange rate regimes based on the experience of advanced countries. The main findings are as follows: first, various puzzles such as the ‘exchange rate puzzle’, ‘delayed overshooting puzzle’ and ‘forward discount bias puzzle’ are frequently found in these countries; and second, more severe puzzles are found in these emerging countries than in small open advanced countries.
ILLUSION OR DELUSION? A RE‐EXAMINATION OF BUDDHIST PHILOSOPHY OF PERSONAL IDENTITY
Authors: Panaïoti Antoine 
Published: August 2021

AbstractIn this article, I argue against the conventional view that Buddhist philosophy of personal identity regards the self as an illusion. Critically engaging the work of Miri Albahari, I defend the view that it is instead centered around the properly diagnostic claim that the overwhelming majority of human beings suffer from a delusion concerning the nature of the self. In the central section of the paper, I draw from contemporary work in philosophy of psychiatry to gain clarity on what delusions are and how they are distinct from illusions. On the narrative theory of delusions I thence develop, delusions are best understood as faulty and harm‐inducing self‐referential narrative constructions. Buddhist views on human beings’ confusion concerning the self, I then submit, consist of the diagnosis of a delusion in precisely this sense. At the end of the article, I argue that in addition to its intrinsic merits this interpretation has the added advantage of bringing into sharper focus the irreducibly therapeutic character of Buddhist philosophy of personal identity, and I discuss the implications of this for future cross‐cultural research on the problem of selfhood.