bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breaking continuity? Site formation and temporal depth at Çatalhöyük and Tell Sabi Abyad
Authors: Plug Jo-Hannah , Hodder Ian , Akkermans Peter M.M.G. 
Published: May 2021

AbstractSpatial continuity of the house is often seen as crucial in providing temporal depth for the Neolithic societies of southwest Asia. While an emphasis on the creation of such continuities is evinced at densely agglomerated sites, other sites are characterised by dispersal and frequent relocation of habitation. Çatalhöyük (Turkey) and Tell Sabi Abyad (Syria) appear to be at either end of this spectrum. However, recently found evidence and reinterpretation of older evidence call into question the apparently stark distinction between the two sites. The purpose of this paper is to compare aspects of the archaeological evidence from Tell Sabi Abyad and Çatalhöyük, and in doing so to understand the different ways in which site formation and social continuity were achieved. In particular, the presence of breaks in spatial continuities – an often overlooked aspect of site formation – and its implications are discussed. It appears that at these two sites both continuity and breaks gave form and meaning to the settlements and to the societies that inhabited them. We argue that social continuities and anchors to the past can be constructed in many variable ways, and that direct spatial continuity of the house is but one.
Nourishing Humanity without Destroying the Planet
Authors: Barnhill Anne , Fanzo Jessica 
Published: May 2021

AbstractAs part of the roundtable, “Ethics and the Future of the Global Food System,” this essay discusses some of the major challenges we will face in feeding the world in 2050. A first challenge is nutritional: 690 million people (9 percent of the world's population) are currently undernourished, while 2.1 billion adults (28 percent of the population) are overweight or obese. The current global food system is insufficient in ensuring that the nutritious foods that make up healthy diets are available and accessible for the world's population. Moreover, by 2050, as the global population increases, food demand will increase by 50–60 percent. A fundamental challenge is meeting this demand while not wreaking irreversible havoc on natural resources, the environment, and planetary systems. A body of scientific research has coalesced around the need to reduce food loss and waste, adopt environmentally sustainable production practices, and shift toward plant-dominant diets. Other long-standing food system problems include deficits in providing fair wages and decent working conditions for food system workers, threats to smallholder farmer livelihoods, and tens of billions of animals kept in welfare-deficit confinement conditions. These food system challenges are bad states of affairs that matter from a variety of moral perspectives. In other words, there is a robust moral case for addressing these challenges. Yet concerted policy action in this area is insufficient and largely absent, pointing to the underlying challenge and complexity of political inertia.
Effect of selective removal of badgers (Meles meles) on ranging behaviour during a ‘Test and Vaccinate or Remove’ intervention in Northern Ireland
Authors: O'Hagan M. J. H. , Gordon A. W. , McCormick C. M. , Collins S. F. , Trimble N. A. , McGeown C. F. , McHugh G. E. , McBride K. R. , Menzies F. D. 
Published: May 2021

AbstractThe role of the Eurasian badger (Meles meles) as a wildlife host has complicated the management of bovine tuberculosis (bTB) in cattle. Badger ranging behaviour has previously been found to be altered by culling of badgers and has been suggested to increase the transmission of bTB either among badgers or between badgers and cattle. In 2014, a five-year bTB intervention research project in a 100 km2area in Northern Ireland was initiated involving selective removal of dual path platform (DPP) VetTB (immunoassay) test positive badgers and vaccination followed by release of DPP test negative badgers (‘Test and Vaccinate or Remove’). Home range sizes, based on position data obtained from global positioning system collared badgers, were compared between the first year of the project, where no DPP test positive badgers were removed, and follow-up years 2–4 when DPP test positive badgers were removed. A total of 105 individual badgers were followed over 21 200 collar tracking nights. Using multivariable analyses, neither annual nor monthly home ranges differed significantly in size between years, suggesting they were not significantly altered by the bTB intervention that was applied in the study area.
Communicability of varicella before rash onset: a literature review
Authors: Marin Mona , Leung Jessica , Lopez Adriana S. , Shepersky Leah , Schmid D. Scott , Gershon Anne A. 
Published: May 2021

AbstractVaricella poses an occupational risk and a nosocomial risk for susceptible healthcare personnel and patients, respectively. Patients with varicella are thought to be infectious from 1 to 2 days before rash onset until all lesions are crusted, typically 4–7 days after onset of rash. We searched Medline, Embase, Cochrane Library and CINAHL databases to assess evidence of varicella-zoster virus (VZV) transmission before varicella rash onset. Few articles (7) contributed epidemiologic evidence; no formal studies were found. Published articles reported infectiousness at variable intervals before rash onset, between <1 day to 4 days prior to rash, with 1–2 patients for each interval. Laboratory assessment of transmission before rash was also limited (10 articles). No culture-positive results were reported. VZV DNA was identified by PCR before rash onset in only one study however, PCR does not indicate infectivity of the virus. Based on available medical literature, VZV transmission before rash onset seems unlikely, although the possibility of pre-rash, respiratory transmission cannot be entirely ruled out.
RECENT INVESTIGATIONS AT TULA CHICO, TULA, HIDALGO
Authors: Cobean Robert H. , Healan Dan M. , Suárez María Elena 
Published: May 2021

AbstractRecent excavations at Tula Chico, the monumental center for Tula's earliest settlement, revealed a long and complex history of occupation, beginning with its initial settlement in the Middle Classic period by Coyotlatelco peoples, when much of the region was under Teotihuacan's direct control. During the Epiclassic period, a program of monumental construction began that developed the monumental complex seen today over a period of about 200 years. Although Tula Chico was superseded by Tula Grande, the monumental center for the Early Postclassic city, it continued to be occupied and maintained until its destruction by fire. Tula Chico and Tula Grande show evidence of clear cultural continuity in ceramics, architecture, and sculpture, including “Toltec style” sculpture characteristic of Tula Grande that is present in temporally early contexts at Tula Chico.
ARCHAEOLOGICAL INVESTIGATIONS IN THE NORTHERN PORTION OF ANCIENT TULA
Authors: Getino Granados Fernando 
Published: May 2021

AbstractSalvage excavations along the right of way of a 2 km stretch of proposed highway crossing the northern part of the Postclassic city of Tula, Hidalgo utilized a multi-phase investigation strategy, featuring pedestrian survey and exploratory test-pitting. This fieldwork led to extensive excavation in five localities, which uncovered significant portions of both elite and non-elite residential compounds, a possible administrative structure, and two temples, one of which is the earliest example of a twin temple pyramid in western Mesoamerica. The diversity of structures and corresponding functions encountered in excavation are comparable to those found in previous excavations that suggest the city was organized into barrios, each with its own political, religious, social, and other institutions that mimic those of the larger urban polity. While these investigations confirm previous evidence of considerable destruction of the ancient city in recent decades, they also demonstrate that significant portions are still intact.
The Qizilbāsh and their Shah: The Preservation of Royal Prerogative during the Early Reign of Shah Ṭahmāsp
Authors: ALDOUS GREGORY 
Published: May 2021

AbstractModern historians of Persia's Safavid period (1501–1722) have long assumed that there was an interregnum between the death of Shah Ismāʿīl I in 1524 and the date when his son Ṭahmāsp came of age and established direct control in the 1530s. This idea of an interregnum takes two forms in the historiography. According to one narrative, during this time the Qizilbāsh amirs were disloyal to the young Ṭahmāsp and tried to seize control of Persia for themselves. According to the other, there was a war of succession in which Qizilbāsh factions supported different sons of Ismāʿīl I. Both of these narratives co-exist in the contemporary historical literature even though they disagree. Based on a close reading of the early Safavid chronicles, this article demonstrates that both narratives are incorrect and there was no interregnum. The Qizilbāsh continued throughout Ṭahmāsp's minority to respect him and treat him as their leader. Unsurprisingly, given his youth and inexperience, he deferred matters of state to his amirs. Nevertheless, his amirs derived their legitimacy to rule from him, and when leadership passed from one amir to another, it did so only with Ṭahmāsp's approval. Moreover, there was no dispute over the succession during Ṭahmāsp's minority.
Antioxidant and inflammatory potential of diet among women at risk of cervical cancer: findings from a cross-sectional study in Italy
Authors: Maugeri Andrea , Barchitta Martina , Magnano San Lio Roberta , Scalisi Aurora , Agodi Antonella 
Published: May 2021

AbstractObjective:To evaluate the association of Composite Dietary Antioxidant Index (CDAI) and Dietary Inflammatory Index (DII) with the prevalence of high-grade cervical intraepithelial neoplasia (CIN).Design:A cross-sectional study was conducted on women with abnormal Papanicolaou test, who underwent high-risk human papillomavirus (HPV) screening and histological test through colposcopy. Dietary data were collected using a FFQ and used to assess both CDAI and DII.Setting:Women were recruited from 2012 to 2015 at the Cervical Cancer Screening Unit of the ‘Azienda Sanitaria Provinciale’ of Catania (Italy).Participants:The study included 539 women with a mean age of 40·2 years, who were classified as cases (n 127 with CIN2 or more severe lesions) and controls (n 412 with normal cervical epithelium or CIN1).Results:Although we observed a lower proportion of HPV-positive women among those with higher CDAI (P < 0·001), the index was not associated with the diagnosis of CIN2 or more severe lesions. By contrast, women with medium or high DII showed higher odds to be diagnosed with CIN2 or more severe lesions than those with low DII (OR = 2·15; 95 % CI 1·11, 4·17; P = 0·024 and OR = 3·14; 95 % CI 1·50, 6·56; P = 0·002, respectively), after adjusting for age, HPV status, educational level, BMI, smoking status, parity, use of oral contraceptives and supplements.Conclusions:Our findings suggested that a pro-inflammatory diet might be associated with an increased risk of CIN2 and more severe lesions. However, further prospective studies should be encouraged to support this evidence.
Changes in the palliative performance scale may be as important as the initial palliative performance scale for predicting survival in terminal cancer patients
Authors: Lee Guk Jin , Gwak Ji Hyun , Kim Myoung Sim , Lee Mi Yeong , Kim Seo Ree , Chun Sang Hoon , Jin Jong Youl 
Published: May 2021

AbstractObjectiveThe accurate estimation of expected survival in terminal cancer patients is important. The palliative performance scale (PPS) is an important factor in predicting survival of hospice patients. The purpose of this study was to examine how initial status of PPS and changes in PPS affect the survival of hospice patients in Korea.MethodWe retrospectively examined 315 patients who were admitted to our hospice unit between January 2017 and December 2018. The patients were divided based on the PPS of ≥50% (group A) and ≤40% (group B). We performed survival analysis for factors associated with the length of survival (LOS) in group A. Based on the hospice team's weekly evaluation of PPS, we examined the effect of initial levels and changes in group A on the prognosis of patients who survived for 2 weeks or more.ResultsAt the time of admission to hospice, 265 (84.1%) patients were PPS ≥50%, and 50 (15.9%) were PPS ≤40%. The median LOS of PPS ≥50% and PPS ≤40% were 15 (2–158 days) and 9 (2–43 days), respectively. Male, gastrointestinal cancer, and lower initial PPS all predicted poor prognosis in group A. Male, gastrointestinal cancer, and a PPS change of 10% or greater, compared with initial status 1 week and 2 weeks of hospitalization, were all predictors of poor prognosis in group A patients who survived for 2 weeks or longer.Significance of resultsOur research demonstrates the significance of PPS change at 1 week and 2 weeks, suggesting the importance of evaluating not only initial PPS but also change in PPS.
Cardiovascular disease and meaning in life: A systematic literature review and conceptual model
Authors: Vos Joel 
Published: May 2021

AbstractObjectivesPrevious studies have shown that psychological stress and mental health problems increase the risk for cardiovascular disease (CVD) events, such as heart attack or stroke. Furthermore, after CVD events, the majority of patients report large stress. However, psychological treatments have only modest effects in CVD patients. Therefore, it has been argued that new conceptual models are needed to understand the aetiology of stress and mental health problems in CVD patients. Therefore, this study included a systematic literature review and a conceptual model on the role of meaning in life for psychological stress, mental health, and CVD risks.MethodsA systematic literature review was conducted on relationships between CVD and meaning in life. PRISMA/MOOSE review guidelines were followed. These findings were used to build a conceptual model.ResultsThe literature review included 113 studies on meaning and CVD. The included studies described meaning as a predictor of cardiovascular risks and health, meaning-centered needs of patients in conversations with medical staff, meaning-centered changes after CVD events, meaning-centered coping with CVD, meaning as motivator of CVD-related lifestyle changes, and meaning as an element in psychological treatments of CVD patients. In sum, the literature showed that a central clinical concern for patients is their question how to live a meaningful life despite CVD. Meaning-centered concerns seem to lead to lower motivation to make lifestyle changes, more psychological stress, lower quality-of-life, worse physical well-being, and increased CVD risk. The ability to live a meaningful life after CVD events is related with lower stress, better mental health, and several biomarkers.Significance of resultsAn evidence-based conceptual framework was developed for the relationship between meaning and CVD. It may be hypothesized CVD patients may benefit from psychological therapies focused on meaning.
Mixture interactions of quizalofop and reduced rates of halosulfuron
Authors: Webster L. Connor , Webster Eric P. , Blouin David C. , McKnight Benjamin M. 
Published: May 2021

AbstractA field study was conducted in 2017 and 2018 at the Louisiana State University Agricultural Center H. Rouse Caffey Rice Research Station near Crowley, LA, to evaluate the impact of reduced rates of halosulfuron on quizalofop activity in Louisiana rice production. Halosulfuron and a prepackaged mixture of halosulfuron plus thifensulfuron were evaluated at 0, 17, 35, or 53 g ai ha−1 and 34 or 53 g ai ha−1, respectively, in a mixture with quizalofop at 120 g ai ha−1. Control of barnyardgrass, red rice, and two non-acetyl-CoA carboxylase resistant rice lines, CL-111 and CLXL-745, were recorded at 14 and 28 d after treatment (DAT). The red rice, CL-111, and CLXL-745 represented a weedy rice population. Across all species evaluated at 14 DAT, all mixtures containing halosulfuron and halosulfuron plus thifensulfuron resulted in antagonism with an observed control of 79% to 90%, compared with an expected control of 96% to 99%. At 28 DAT, all mixtures containing halosulfuron resulted in neutral interactions for barnyardgrass control. Quizalofop mixed with halosulfuron plus thifensulfuron at the lower rate of 34 g ha−1 was able to overcome the antagonism compared with the higher rate of 53 g ha−1 for barnyardgrass control at 28 DAT. Both the high and the low rate of halosulfuron plus thifensulfuron resulted in antagonistic interaction for red rice, CL-111, and CLXL-745 control at 28 DAT. This research suggests that mixing quizalofop with halosulfuron plus thifensulfuron should be avoided, especially at the higher rate of 53 g ha−1.
Higher dietary total antioxidant capacity (TAC) reduces the risk of cardio-metabolic risk factors among adults: An updated systematic review and meta-analysis
Authors: Farhangi Mahdieh Abbasalizad , Mohammad-Rezaei Ali 
Published: May 2021

Abstract: Background: Numerous studies have revealed the protective role of dietary antioxidants against hypertension and diabetes. In the current systematic review and meta-analysis, we evaluated the possible role of dietary total antioxidant capacity (TAC) against metabolic parameters in the adult population. Methods: A literature search of authentic electronic resources including PubMed, Scopus, Web of Sciences, and Cochrane had been performed to retrieve the qualified observational studies that reported the mean plus/minus the SD for the parameter in subjects of the highest versus lowest dietary TAC categories up to July 2020. Results: Totally, the number of included studies was 13 for fasting blood sugar (FBS), 12 for systolic blood pressure (SBP), and 12 for diastolic blood pressure (DBP), with the participants’ number of 26349. The results of the current study showed that being at highest category of TAC significantly reduces serum FBS (WMD: −2.381; CI: −3.445, −1.316; P<0.001), SBP (WMD: −1.080; CI: −1.458, −0.701; P<0.001) and DBP (WMD: −0.854; CI: −1.655, −0.052; P<0.001), while no significant difference in the serum insulin, HOMA-IR values, prevalence of type 2 diabetes (T2DM) (P=0.37) and hypertension (HTN) (P=0.09) was observed. Subgroup analysis revealed the geographical location, dietary assessment tool, sample size, and gender as possible sources of heterogeneity. Conclusion: Higher intake of dietary TAC was associated with reduced SBP, DBP, and FBS in the current observational studies of this meta-analysis. These findings further confirm the clinical importance of dietary antioxidants in the prevention of different metabolic disorders.
Climatic and Topographic Control of the Stable Isotope Values of Rivers on the South Island of New Zealand
Authors: Lachniet Matthew S. , Moy Christopher M. , Riesselman Christina , Stephen Haroon , Lorrey Andrew M. 
Published: May 2021

AbstractWe show that climate and topography control the spatial distribution of stable isotope values on the South Island of New Zealand, based on a spatially dense (n = 193) river isotopic survey. Our data show a δ18O minimum in isotope values east of the Southern Alps that demonstrates topographically driven continentality associated with the Southern Alps, which intersect the prevailing, moisture‐laden westerlies. Our data define a South Island surface water line of δ2H = 8.17 (±0.26) × δ18O + 10.57 (±2.04), which is identical within 95% confidence intervals to the global and New Zealand meteoric water lines established from monthly precipitation samples. The observed river δ18O values are strongly correlated with annual temperature range and winter temperature. Strongest correlations are between δ18O and mean minimum winter temperatures (r > 0.7 for June, July, August), with gradients of 0.58–0.66‰ /°C. Based on a multiple regression analysis of δ18O against climate data, we present a river δ18O model and isoscape that demonstrate the control of continentality and moisture source on New Zealand surface water isotope spatial patterns. Model validation against previously published river samples shows skill in predicting river δ18O values (root‐mean‐square error = 0.83), confirming that the spatial variations in river δ18O (and δ2H) are robust to sampling period and reflect continental, precipitation source and temperature effects. Our data suggest that oxygen or hydrogen isotope paleoclimate proxies derived from rivers or open‐system lakes on the South Island should be sensitive to winter temperature.
YAP inhibits autophagy and promotes progression of colorectal cancer via upregulating Bcl-2 expression
Authors: Jin Lan , Chen Yunhe , Cheng Dan , He Zhikai , Shi Xinyi , Du Boyu , Xi Xueyan , Gao Yujing , Guo Yang 
Published: May 2021

AbstractColorectal cancer (CRC) is one of the most aggressive and lethal cancers. The role of autophagy in the pathobiology of CRC is intricate, with opposing functions manifested in different cellular contexts. The Yes-associated protein (YAP), a transcriptional coactivator inactivated by the Hippo tumor-suppressor pathway, functions as an oncoprotein in a variety of cancers. In this study, we found that YAP could negatively regulate autophagy in CRC cells, and consequently, promote tumor progression of CRC in vitro and in vivo. Mechanistically, YAP interacts with TEAD forming a complex to upregulate the transcription of the apoptosis-inhibitory protein Bcl-2, which may subsequently facilitate cell survival by suppressing autophagy-related cell death; silencing Bcl-2 expression could alleviate YAP-induced autophagy inhibition without affecting YAP expression. Collectively, our data provide evidence for YAP/Bcl-2 as a potential therapeutic target for drug exploration against CRC.
Learning with reinforcement prediction errors in a model of the Drosophila mushroom body
Authors: Bennett James E. M. , Philippides Andrew , Nowotny Thomas 
Published: May 2021

AbstractEffective decision making in a changing environment demands that accurate predictions are learned about decision outcomes. In Drosophila, such learning is orchestrated in part by the mushroom body, where dopamine neurons signal reinforcing stimuli to modulate plasticity presynaptic to mushroom body output neurons. Building on previous mushroom body models, in which dopamine neurons signal absolute reinforcement, we propose instead that dopamine neurons signal reinforcement prediction errors by utilising feedback reinforcement predictions from output neurons. We formulate plasticity rules that minimise prediction errors, verify that output neurons learn accurate reinforcement predictions in simulations, and postulate connectivity that explains more physiological observations than an experimentally constrained model. The constrained and augmented models reproduce a broad range of conditioning and blocking experiments, and we demonstrate that the absence of blocking does not imply the absence of prediction error dependent learning. Our results provide five predictions that can be tested using established experimental methods.