bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spectrum of hematological malignancies, clonal evolution and outcomes in 144 Mayo Clinic patients with germline predisposition syndromes
Authors: Martin Emma St , Ferrer Alejandro , Mangaonkar Abhishek A. , Khan Shakila P. , Kohorst Mira A. , Joshi Avni Y. , Hogan William J. , Olteanu Horatiu , Moyer Ann M. , Al‐Kali Aref , Tefferi Ayalew , Chen Dong , Wudhikarn Kitsada , Go Ronald , Viswanatha David , He Rong , Ketterling Rhett , Nguyen Phuong L. , Oliveira Jennifer L. , Gangat Naseema , Lasho Terra , Patnaik Mrinal M. 
Published: August 2021

AbstractGermline predisposition syndromes (GPS) result from constitutional aberrations in tumor suppressive and homeostatic genes, increasing risk for neoplasia in affected kindred. In this study, we present clinical and genomic data on 144 Mayo Clinic patients with GPS; 59 evaluated prospectively using an algorithm‐based diagnostic approach in the setting of a dedicated GPS/ inherited bone marrow failure syndrome (IBMFS) clinic. Seventy‐two (50%) patients had IBMFS (telomere biology disorders‐32,Fanconi anemia‐18, Diamond Blackfan Anemia – 11, congenital neutropenia–5, Schwachman‐Diamond Syndrome‐5 and Bloom Syndrome‐1), 27 (19%) had GPS with antecedent thrombocytopenia (RUNX1‐FPD‐15, ANKRD26‐6, ETV6‐2, GATA1‐1, MPL‐3), 28 (19%) had GPS without antecedent thrombocytopenia (GATA2 haploinsufficiency‐16, DDX41‐10, CBL‐1 and CEBPA‐1) and 17 (12%) had general cancer predisposition syndromes (ataxia telangiectasia‐7, heterozygous ATM variants‐3, CHEK2‐2, TP53‐2, CDK2NA‐1, NF1‐1 and Nijmegen Breakage Syndrome‐1). Homozygous and heterozygous ATM pathogenic variants were exclusively associated with lymphoproliferative disorders (LPD), while DDX41 GPS was associated with LPD and myeloid neoplasms. The use of somatic NGS‐testing identified clonal evolution in GPS patients, with ASXL1, RAS pathway genes, SRSF2 and TET2 being most frequently mutated. Fifty‐two (91%) of 59 prospectively identified GPS patients had a change in their management approach, including additional GPS‐related screening in 42 (71%), referral for allogenic HSCT workup and screening of related donors in 16 (27%), medication initiation and selection of specific conditioning regimens in 14 (24%), and genetic counseling with specific intent of fertility preservation and preconceptual counseling in 10 (17%) patients; highlighting the importance of dedicated GPS screening, detection and management programs for patients with hematological neoplasms.
A cluster of hypersensitivity pneumonitis associated with exposure to metalworking fluids
Authors: Tustin Aaron W. , Cooney Ryan , Lamson Glenn E. , Hodgson Michael J. 
Published: August 2021

AbstractBackgroundWorkers exposed to metalworking fluids (MWF) can develop respiratory illnesses including hypersensitivity pneumonitis (HP). These respiratory manifestations are likely due to microbial contamination of aerosolized MWF. This paper reports a cluster of HP and respiratory symptoms at a manufacturing plant where MWF and workplace air were contaminated with bacterial endotoxin despite frequent negative bacterial cultures of MWF.MethodsA pulmonologist assessed and treated three workers with respiratory symptoms. The Occupational Safety and Health Administration (OSHA) inspected the plant. OSHA's investigation included bacterial culture of MWF, measurement of endotoxin concentrations in MWF and workplace air, review of the employer's fluid management program, and distribution of a cross‐sectional symptom questionnaire.ResultsThree workers had biopsy‐confirmed HP. In addition, 30.8% of questionnaire respondents reported work‐related respiratory symptoms. OSHA detected endotoxin levels as high as 92,000 endotoxin units (EU)/ml in MWF and 3200 EU/m3 in air. Endotoxin concentrations and risk of MWF inhalation were highest near an unenclosed multistation computer numerical control machine. A contractor had tested this machine's MWF for bacterial growth weekly during the preceding three years, and most (96.0%) of those tests were negative.ConclusionsContaminated MWF can cause severe occupational lung disease even if microorganisms do not grow in fluid cultures. Endotoxin testing can increase the sensitivity of detection of microbial contamination. However, employers should not rely solely upon MWF testing data to protect workers. Medical surveillance and meticulous source control, such as engineering controls to suppress MWF mist and prevent its inhalation, can reduce the likelihood of respiratory disease.
Single‐Molecule Frequency Fingerprint for Ion Interaction Networks in a Confined Nanopore
Authors: Li Xinyi , Ying Yi‐Lun , Fu Xi‐Xin , Wan Yong‐Jing , Long Yi‐Tao 
Published: August 2021

AbstractThe transport of molecules and ions through biological nanopores is governed by interaction networks among restricted ions, transported molecules, and residue moieties at pore inner walls. However, identification of such weak ion fluctuations from only few tens of ions inside nanopore is hard to achieve owing to electrochemical measurement limitations. Here, we developed an advanced frequency method to achieve qualitative and spectral analysis of ion interaction networks inside a nanopore. The peak frequency fm reveals the dissociation rate between nanopore and ions; the peak amplitude am depicts the amount of combined ions with the nanopore after interaction equilibrium. A mathematical model for single‐molecule frequency fingerprint achieved the prediction of interaction characteristics of mutant nanopores. This single‐molecule frequency fingerprint is important for classification, characterization, and prediction of synergetic interaction networks inside nanoconfinement.
Ordered Conformation‐Regulated Vesicular Membrane Permeability
Authors: Zheng Yi , Wang Zuojie , Li Zifen , Liu Hang , Wei Jing , Peng Chuan , Zhou Yeqiang , Li Jianshu , Fu Qiang , Tan Hong , Ding Mingming 
Published: August 2021

AbstractIn nature, the folding and conformation of proteins can control the cell or organelle membrane permeability and regulate the life activities. Here we report the first example of synthetic polypeptide vesicles that regulate their permeability via ordered transition of secondary conformations, in a manner similar to biological systems. The polymersomes undergo a β‐sheet to α‐helix transition in response to reactive oxygen species (ROS), leading to wall thinning without loss of vesicular integrity. The change of membrane structure increases the vesicular permeability and enables specific transport of payloads with different molecular weights. As a proof‐of‐concept, the polymersomes encapsulating enzymes could serve as nanoreactors and carries for glucose‐stimulated insulin secretion in vivo inspired by human glucokinase, resulting in safe and effective treatment of type 1 diabetes mellitus in mouse models. This study will help understand the biology of biomembranes and facilitate the engineering of nanoplatforms for biomimicry, biosensing, and controlled delivery applications.
Sun coral management effectiveness in a wildlife refuge from south‐eastern Brazil
Authors: Savio Lucca A. C. , Dias Gustavo M. , Leite Kelen L. , Godoi Silvia N. , Figueiroa Apoena C. , Neto Geraldo F. O. , Correa Edineia C. , Francini Carlo L. B. , Shintate Gustavo , Kitahara Marcelo V. 
Published: August 2021

Abstract

The introduction of exotic species is one of the major causes for biodiversity loss in marine environments. Introduced species can change habitat complexity, impacting local communities and altering ecosystem functioning.
Since the 1980s, the scleractinian species Tubastraea coccinea and Tubastraea. tagusensis (commonly known as sun corals) have been spreading in the south‐western Atlantic, posing a major threat to local biodiversity and marine ecosystems. Nowadays, these species are reported from more than 3,500 km along the Brazilian coast and on at least 21 oil and gas offshore platforms.
Considering the great environmental pressure resulting from sun coral invasion, this study verified the effectiveness of manual removal of Tubastraea spp. along a rocky shore in Alcatrazes Wildlife Refuge, one of the most pristine marine regions in Brazil.
Results indicate that removal is indeed effective as a control technique; however, as invaders have high regeneration capabilities and recruitment rates, successive management efforts are essential. In order for management to be effective against Tubastraea's year‐round release of clonal larvae, results suggest invaded areas should receive at least two management actions per year.
Successive management efforts, in addition to the development of new techniques and prevention of new invasions should be priorities for mitigating sun coral impacts.
Further analysis of psychotropic medication and severe problem behavior
Authors: Falligant John M. , Bednar Molly K. 
Published: August 2021

AbstractCox et al. (2021) recently outlined a number of analytic methods (i.e., procedures for estimating effect size, conditional rates, and nonparametric partial correlation tests) that may help quantify the relative contributions of psychotropic medication and behavioral interventions on problem behavior among individuals with intellectual and developmental disorders. The purpose of the current study was to examine the generality of these methods by applying these procedures in a novel clinical context (i.e., a hospital‐based inpatient unit for severe problem behavior). We extended the procedures described by Cox to include a larger sample size, cases with more frequent, severe and treatment‐resistant problem behavior, cases with both medication decreases and increases, and cases with at least one similar class of psychotropic medication in common (i.e., atypical antipsychotics). This work remains a proof of concept, but we replicated a number of the preliminary findings from Cox et al. Implications for future research and medication monitoring practices are discussed.
Metabolic regulation and optimization of oxygen supply enhance the 2,3‐butanediol yield of the novel Klebsiella sp. isolate FSoil 024
Authors: Chu Wanying , Jiang Ke , Lu Ping , Xu Yudong , Yang Jiayao , Wei Xuan , Li Li , Liu Shuxin , Wu Yan , Wang Shenghou , Zhao Hongxin 
Published: August 2021

AbstractBackgroundBiogenic 2,3‐butanediol (2,3‐BDO) is a high‐value‐added compound that can be used as a liquid fuel and a platform chemical. Bioproduction of 2,3‐BDO is an environmentally friendly choice.Method and ResultsThree recombinant derivatives of the novel Klebsiella sp. isolate FSoil 024 (WT) were constructed via different strategies including deletion of lactate dehydrogenase by λ‐Red homologous recombination technology, overexpression of the small‐noncoding RNA RyhB and a combination of both. The 2,3‐BDO productivity of the mutants increased by 61.3%–79%, and WT‐Δldh/ryhB displayed the highest 2,3‐BDO yield of 42.36 mM after 24 h of shake‐flask fermentation. Glucose was shown as the best carbon source for 2,3‐BDO production by WT‐Δldh/ryhB. In addition, higher oxygenation was favorable for ideal product synthesis. The maximal 2,3‐BDO yield of WT and WT‐Δldh/ryhB were increased by 23.3% and 52.5% respectively compared to the control group in the presence of 70% oxygen (V:V’ = O2:(O2 + N2)).Conclusion and ImplicationsAccording to the present study, deletion of lactate dehydrogenase, RyhB overexpression, and manipulation of oxygen supply showed great impacts on cell growth, 2,3‐BDO productivity and cellular metabolism of the novel isolated strain Klebsiella sp. FSoil 024. This work would also provide insights for promoting 2,3‐BDO biosynthesis for industrial applications.
Chemical‐activity‐based quality marker screening strategy for Viscum articulatum
Authors: Wei Xu‐Ya , Guo Wen‐Jing , Chen Ze‐Yan , Qiu Zi‐Dong , Guo Juan , Cui Guang‐Hong , Wang Ya‐Nan , Gong Li , Chen Lan‐Ying , Lai Chang‐Jiang‐Sheng , Huang Lu‐Qi 
Published: August 2021

AbstractViscum articulatum Burm. f. is a parasitic plant rich in flavonoids, triterpenoids, and catechins and has a high nutritional value. It has been reported that consuming V. articulatum can prevent cardiac diseases. In this study, six bioactive compounds, including catechins, triterpenoids, and phenylpropanoid glycosides, were determined in alcohol extracts of the plant using HPLC. The anti‐inflammatory and antioxidant activities of three catechins, two triterpenoids, and three combination drugs were measured in cardiomyocytes, and the results showed that the anti‐inflammatory activity was significantly enhanced while retaining strong antioxidant activity when epicatechin and ursolic acid were used in combination. The main quality markers epicatechin and ursolic acid were screened based on the specificity of the genuine herb and a potent synergistic effect, and the lowest limitation contents of V. articulatum which could discriminate it from some other taxonomically similar materials were accordingly determined. This self‐built lowest limitation content of the two screened quality markers could quickly and accurately reflect the efficacy in terms of chemical composition and reverse the disorderly market use of nongenuine herbs or confusing species for adulteration. This study is of some significance for market regulation, drug development, and clinical medication.
Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma
Authors: Xia Yujia , Brown Zachary J. , Huang Hai , Tsung Allan 
Published: August 2021

AbstractHepatocellular carcinoma (HCC) is a typical inflammation‐induced cancer and displays a complex interaction between the tumor microenvironment and tumor development. Immune cells in the HCC microenvironment play both pro‐ and anti‐tumoral roles in HCC progression. An increasing number of findings indicate that metabolic reprogramming is essential for immune cell differentiation and function. In this review, we discuss the metabolic changes of different immune cells and correlate these findings to HCC progression.
Prevalence and predictors of peripheral neuropathy after breast cancer treatment
Authors: Kamgar Mandana , Greenwald Mark K. , Assad Hadeel , Hastert Theresa A. , McLaughlin Eric M. , Reding Kerryn W , Paskett Electra D. , Bea Jennifer W. , Shadyab Aladdin H. , Neuhouser Marian L. , Nassir Rami , Crane Tracy E. , Sreeram Kalyan , Simon Michael S. 
Published: August 2021

AbstractBackgroundMany of the 3.8 million breast cancer survivors in the United States experience long‐term side effects of cancer therapy including peripheral neuropathy (PN). We assessed the prevalence and predictors of PN among women with breast cancer followed in the Women's Health Initiative's Life and Longevity After Cancer survivorship cohort.MethodsThe study population included 2420 women with local (79%) or regional (21%) stage disease. Presence of PN was based on the reports of “nerve problems and/or tingling sensations” after treatment and PN severity was assessed using the Functional Assessment of Cancer Therapy‐Gynecologic Oncology Group/Neurotoxicity instrument. Logistic regression analysis was used to evaluate the socio‐demographic and clinical factors associated with PN prevalence and severity.ResultsInitial breast cancer treatment included surgery‐only (21%), surgery and radiation (53%), or surgery and chemotherapy (±radiation) (26%). Overall, 17% of women reported PN occurring within days (30%), months (46%), or years (24%) after treatment and 74% reported ongoing symptoms at a median of 6.5 years since diagnosis. PN was reported by a larger proportion of chemotherapy recipients (33%) compared to those who had surgery alone (12%) or surgery+radiation (11%) (p < 0.0001). PN was reported more commonly by women treated with paclitaxel (52%) and docetaxel (39%), versus other chemotherapy (17%) (p < 0.0001). In multivariable analyses, treatment type (chemotherapy vs. none; OR, 95% CI: 3.31, 2.4–4.6), chemotherapy type (taxane vs. no‐taxane; 4.74, 3.1–7.3), and taxane type (paclitaxel vs. docetaxel; 1.59, 1.0–2.5) were associated with higher odds of PN.ConclusionPN is an important long‐term consequence of taxane‐based chemotherapy in breast cancer survivors.
How loyalty extends across product categories
Authors: Grasby Alicia , Corsi Armando , Dawes John , Driesener Carl , Sharp Byron 
Published: August 2021

AbstractFifty years ago, Gerald Goodhardt's analysis of audience duplication across television programs led to the discovery of the Duplication of Viewing law. This law was then extended to describe and predict customer sharing within product categories: the Duplication of Purchase Law. Many replications and extensions documented the law‐like status of this generalisation, providing important insight into how brands compete and the composition of consumers' repertoires. In this article we build on that seminal research, using Duplication of Purchase as an analytical method to measure loyalty across categories, or, in other words, the purchasing of brand extensions. Brand extensions are commonly cited as a way to capitalise on brand equity, and when asked, respondents often report high intentions to purchase brand extensions. However, the actual cross category buying of brand extensions has not been systematically examined. In this research we analyse panel data to understand whether purchasing a brand in one category does in fact increase the likelihood of a brand being bought in a second category. The study finds that a consumer who purchases from two categories is on average 2.4 times more likely to purchase a brand extension in the second category if they had purchased the same brand in the other category. This effect is larger for brands spanning similar, or complementary categories. Therefore, for many brand extensions the cross‐category loyalty effect is much more modest.
Mental health in immigration detention: A comparison of foreign national ex‐prisoners and other detainees
Authors: Sen Piyal , Crowley Grace , Moro Claira , Slade Karen , Khan Al Aditya , Katona Cornelius , Forrester Andrew 
Published: August 2021

AbstractBackgroundPeople held in immigration removal centres have a range of vulnerabilities relating both to disappointment at imminent removal from the country of hoped‐for residence and various antecedent difficulties. An important subgroup in the UK is of foreign national ex‐prisoners who have served a period of incarceration there. Prisoners generally have higher rates of mental disorders than the general population. It is, however, not clear whether foreign national ex‐prisoners in UK immigration removal centres have higher rates of mental disorders than other detainees.AimsTo compare the screened prevalence of mental disorders, levels of unmet needs and time in detention between foreign national ex‐prisoners and others in Immigration Removal Centres in England.MethodsWe conducted a secondary analysis of cross‐sectional survey data from a previously published study in one Immigration Removal Centre.ResultsThe 28 foreign national ex‐prisoners had been in immigration detention for longer and reported greater levels of unmet needs than the other 66 detainees. The highest levels of unmet needs among the foreign national ex‐prisoners were in the areas of psychological distress and intimate relationships. After adjusting for time spent in detention, there was evidence to suggest that foreign national ex‐prisoners had a higher screened prevalence of substance use disorders, autism spectrum disorders and attention‐deficit hyperactivity disorder than the other detainees.Conclusions/Implications for Clinical PracticeThis study supports the view that foreign national ex‐prisoners are a vulnerable group within immigration detention who have needs for enhanced and specialist service provision, including appropriate arrangements for health screening and active consideration to alternatives to their detention.
Diabetes mellitus is independently associated with early stent thrombosis in patients undergoing drug eluting stent implantation: Analysis from the Victorian cardiac outcomes registry
Authors: Nogic Jason , Nerlekar Nitesh , Soon Kean , Freeman Melanie , Chan Jasmine , Roberts Louise , Brennan Angela , Dinh Diem , Lefkovits Jeffrey , Brown Adam J. 
Published: August 2021

AbstractBackgroundDiabetes mellitus (DM) is a predictor of restenosis and late stent thrombosis (ST) in patients undergoing percutaneous coronary intervention (PCI) with drug‐eluting‐stents (DES). Real‐world data on rates of early ST is lacking. We compared clinical outcomes of patients with and without DM from the Victorian cardiac outcomes registry.MethodsConsecutive patients undergoing PCI with DES were analyzed with primary outcome being ST at 30‐days. Secondary outcomes including major adverse cardiovascular events (MACE) and all‐cause mortality.ResultsOf 43,209 patients included, 9730 (22.5%) had DM. At 30 days, DM was independently associated with higher rates of early ST (0.7% vs. 0.5%) OR 1.41 (95% confidence interval; 1.05–1.87, p = 0.02), MACE (4.1% vs. 3.5%, p = 0.004) and mortality (1.9% vs. 1.5%, p = 0.01). Increased risk was not simply due to treatment. Patients with DM requiring insulin were equally affected in regard to MACE (4.7% vs. 3.9%, p = 0.069) and mortality (1.9%, vs. 1.8%, p = 0.746). On National Death Index linkage, patients with DM had increased all‐cause mortality over five‐year follow‐up (OR 1.69 CI 1.55–1.83, p = < 0.001).ConclusionIn this large real‐world‐registry, DM was an independent predictor of early ST, MACE and mortality at 30 days. These data suggest additional therapeutic strategies are required to reduce the risk of early complications in patients with DM undergoing PCI with DES.
Prophylactic permanent pacemaker strategy in patients with right bundle branch block undergoing transcatheter aortic valve replacement
Authors: Fukutomi Motoki , Hokken Thijmen , Wong Ivan , Bieliauskas Gintautas , Daemen Joost , de Jaegere Peter , Van Mieghem Nicolas , Søndergaard Lars , De Backer Ole 
Published: August 2021

AbstractObjectivesTo report on the experience with a selective prophylactic permanent pacemaker (PPx‐PPM) implantation strategy in patients with pre‐existing right bundle branch block (RBBB) undergoing transcatheter aortic valve replacement (TAVR).BackgroundPre‐existing RBBB is an independent predictor for PPM after TAVR and has been linked to increased mortality.MethodsHospital patient flow and longer‐term clinical endpoints were compared for TAVR patients with pre‐existing RBBB treated in a period with and without selective PPx‐PPM strategy (2013–2020).ResultsA total of 260 patients were included: 170 in the early period without PPx‐PPM strategy and 90 patients in the late period with selective PPx‐PPM strategy. A PPx‐PPM was implanted in 44% of patients in the late period. Overall, 69% versus 80% of all patients in the early versus late period ended up with a PPM (p = .06). Streamlined transfemoral TAVR was routinely used from 2017—in this series of patients, both TAVR procedural time and hospital length of stay (LoS) were significantly shorter in the late versus early period (mean procedural time: 70 vs. 83 min and LoS ≥5 days: 15% vs. 40%; p < .05). No difference in all‐cause/cardiovascular mortality was observed between both strategies, whereas cardiac rehospitalization was significantly higher for patients treated in the early versus late period (hazard ratio 2.33 [1.04–5.26]; p = .042)—this mainly due to (sub)acute PPM‐implantation early after discharge.ConclusionsSelective prophylactic PPM implantation in TAVR candidates with pre‐existing RBBB results in shorter TAVR procedural time and hospital LoS and prevents early cardiac rehospitalization related to complete heart block.