bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementing a successful proactive telephone breastfeeding peer support intervention: volunteer recruitment, training, and intervention delivery in the RUBY randomised controlled trial
Authors: Grimes Heather A. , McLachlan Helen L. , Forster Della A. , McLardie-Hore Fiona , Mortensen Kate , Shafiei Touran 
Published: December 2021

Abstract
Background
The RUBY randomised controlled trial demonstrated the benefit of proactive telephone peer support in promoting breastfeeding continuation in a setting with high breastfeeding initiation, where typically this is difficult to achieve. This paper describes the implementation and delivery of the peer support intervention with a focus on recruitment, training, and support of peer volunteers, and includes a description of the key components of the calls.

Methods
Data collection occurred between December 2012 and June 2016 in Melbourne, Australia. Volunteers completed enrolment forms at the training session and recorded data related to each call in a Call Log maintained for each mother supported. Data were summarised using descriptive statistics and responses to open-ended questions analysed using content analysis.

Results
A total of 693 women expressed interest in the peer support role, with 246 completing training, that is, 95% of whom supported at least one mother. Each supported a mean of two mothers (range 1 to 11). Training session topics included respecting individual values, using positive language, confidence building, active listening, empathetic support, and normal baby behaviour. There were 518 periods of support where at least one call was made between a volunteer and a mother to whom she was allocated. Of the 518 periods of support, 359 Call Logs (69%) were returned. The 359 call logs recorded a total of 2398 calls between peers and mothers. Call length median duration was 12 min (range 1 to 111 min). Volunteers perceived the most valued aspects of the calls were the provsion of ‘general emotional support’ (51%) and ‘general information/discussion about breastfeeding’ (44%). During the first call, mothers raised questions about ‘nipple pain/ damage’ (24%) and 'general breastfeeding information’ (23%). At ≥12 weeks postpartum, issues raised related to ‘normal infant behaviour’ (22%), ‘feed frequency’ (16%), and ‘general breastfeeding information’ (15%). Volunteers referred women to other resources during 28% of calls, most commonly to the Australian Breastfeeding Association.

Conclusions
Our findings demonstrate that the RUBY trial was feasible and sustainable in terms of recruiting volunteers who were willing to participate in training and who proceeded to provide peer support. Call content was responsive to the evolving breastfeeding information needs of mothers and the provision of emotional support was perceived by volunteers to be important.

Trial registration
Australian New Zealand Clinical Trials Registry, ACTRN 12612001024831.
A study of the labor process from a technology transformation perspective: the case of internet virtual teams
Authors: Liang Meng 
Published: December 2021

AbstractThis article presents an empirical study of the labor process of internet virtual teams. It argues that organizations with a “horizontally virtual and vertically real” structure face a dilemma in the virtual team labor process. While a culture of engineers, which embodies equality, liberty, and cooperation, is the cultural basis of the virtual team, management is bureaucratic, emphasizing individual interests and hierarchical features. The coexistence of the two leads to cooperation and division of labor in virtual teams. Essentially, this is a compromising institutional arrangement adopted by corporations to triangulate technology culture and managerial control to obtain surplus value. Based on the preceding discussion, this paper ends by proposing a new theoretical framework for studying the labor process under the technological conditions of the internet.
Endothelial-specific depletion of TGF-β signaling affects lymphatic function
Authors: Fukasawa Kunpei , Hanada Kako , Ichikawa Kei , Hirashima Masanori , Takagi Takahiro , Itoh Susumu , Watabe Testuro , Itoh Fumiko 
Published: December 2021

Abstract
Background
Transforming growth factor (TGF)-β is a multifunctional cytokine involved in cell differentiation, cell proliferation, and tissue homeostasis. Although TGF-β signaling is essential for maintaining blood vessel functions, little is known about the role of TGF-β in lymphatic homeostasis.

Methods
To delineate the role of TGF-β signaling in lymphatic vessels, TβRIIfl/fl mice were crossed with Prox1-CreERT2 mice to generate TβRIIfl/fl; Prox1-CreERT2 mice. The TβRII gene in the lymphatic endothelial cells (LECs) of the conditional knockout TβRIIiΔLEC mice was selectively deleted using tamoxifen. The effects of TβRII gene deletion on embryonic lymphangiogenesis, postnatal lymphatic structure and drainage function, tumor lymphangiogenesis, and lymphatic tumor metastasis were investigated.

Results
Deficiency of LEC-specific TGF-β signaling in embryos, where lymphangiogenesis is active, caused dorsal edema with dilated lymphatic vessels at E13.5. Postnatal mice in which lymphatic vessels had already been formed displayed dilation and increased bifurcator of lymphatic vessels after tamoxifen administration. Similar dilation was also observed in tumor lymphatic vessels. The drainage of FITC-dextran, which was subcutaneously injected into the soles of the feet of the mice, was reduced in TβRIIiΔLEC mice. Furthermore, Lewis lung carcinoma cells constitutively expressing GFP (LLC-GFP) transplanted into the footpads of the mice showed reduced patellar lymph node metastasis.

Conclusion
These data suggest that TGF-β signaling in LECs maintains the structure of lymphatic vessels and lymphatic homeostasis, in addition to promoting tumor lymphatic metastasis. Therefore, suppression of TGF-β signaling in LECs might be effective in inhibiting cancer metastasis.
Quality 4.0 for Processes and Customers
Authors: Efimova Anastasia , Briš Petr 
Published: December 2021

Purpose: Considering the speed of technological development towards the Industry 4.0 era the change is necessary for managerial aspects in industrial companies. In this paper an attempt is made to understand the influence of Industry 4.0 technologies on the Quality 4.0 concept better.
Methodology/Approach: Two aspects were analysed in order to achieve the goal – the influence of Industry 4.0 on quality management and the influence of Quality 4.0 on customer satisfaction. The paper is based on a literature review and a pilot study based on questionnaires prepared for research purposes.
Findings: It was found out that the emergence of new technologies is beneficial for Quality Management processes and customer satisfaction. Moreover, the influence is greatly described by the amount of data now available for analysis. However, as the concept of Quality 4.0 is in its infancy, the necessary change is still required.
Research Limitation/Implication: As the research was conducted in the Czech Republic, the results are limited according to the territory. Also, the study was based on the literature review available from SCOPUS and WoS databases in English, thus further studies of available literature in other languages might be needed.
Originality/Value of paper: Although the quality tools that are used in Quality 4.0 are already known and accepted the influence of advanced technologies on quality management is not clear. In this paper an attempt is made to understand the influence.
Identification of Environmentally Friendly Alternative for Laundry Detergent Packaging
Authors: Palfy Pavol , Marenčíková Barbora 
Published: December 2021

Purpose: The objective of the study was to analyse and evaluate two alternative liquid detergent packaging systems from the point of view of their overall environmental impact. Using the LCA method, we have come to the conclusion that cardboard packaging is an alternative with a lower negative impact on the environment than an HDPE bottle.
Methodology/Approach: The study is based on the LCA method implemented through the software openLCA, including available databases.
Findings: The environmentally friendlier alternative of the detergent packaging is identified. The decisions about individual stages during LCA must be made with caution and well documented to ensure credibility of the results.
Research Limitation/Implication: The findings of the presented study are limited by the available data used for the environmental impact assessment. The inventory analysis was performed for the conditions of the central European region.
Originality/Value of paper: This study applies LCA methodology to present the details of a decision process involved in selecting better environmental alternative of the product. The information generated by the study is directly applicable in the industry.
What are the best diagnostic tests for diagnosing bacterial arthritis of a native joint?
Authors: Walinga Alex B. , Stornebrink Tobias , Langerhuizen David W. G. , Struijs Peter A. A. , Kerkhoffs Gino M. M. J. , Janssen Stein. J. 
Published: December 2021

Aims This study aimed to answer two questions: what are the best diagnostic methods for diagnosing bacterial arthritis of a native joint?; and what are the most commonly used definitions for bacterial arthritis of a native joint? Methods We performed a search of PubMed, Embase, and Cochrane libraries for relevant studies published between January 1980 and April 2020. Of 3,209 identified studies, we included 27 after full screening. Sensitivity, specificity, area under the curve, and Youden index of diagnostic tests were extracted from included studies. We grouped test characteristics per diagnostic modality. We extracted the definitions used to establish a definitive diagnosis of bacterial arthritis of a native joint per study. Results Overall, 28 unique diagnostic tests for diagnosing bacterial arthritis of a native joint were identified. The following five tests were deemed most useful: serum ESR (sensitivity: 34% to 100%, specificity: 23% to 93%), serum CRP (sensitivity: 58% to 100%, specificity: 0% to 96%), serum procalcitonin (sensitivity: 0% to 100%, specificity: 68% to 100%), the proportion of synovial polymorphonuclear cells (sensitivity: 42% to 100%, specificity: 54% to 94%), and the gram stain of synovial fluid (sensitivity: 27% to 81%, specificity: 99% to 100%). Conclusion Diagnostic methods with relatively high sensitivities, such as serum CRP, ESR, and synovial polymorphonuclear cells, are useful for screening. Diagnostic methods with a relatively high specificity, such as serum procalcitonin and synovial fluid gram stain, are useful for establishing a diagnosis of bacterial arthritis. This review helps to interpret the value of various diagnostic tests for diagnosing bacterial arthritis of a native joint in clinical practice. Cite this article: Bone Joint J 2021;103-B(12):1745–1753.
Biogeography and genetic diversity of clinical isolates of Burkholderia pseudomallei in Sri Lanka
Authors: Jayasinghearachchi Himali S. , Corea Enoka M. , Jayaratne Kumari I. , Fonseka Regina A. , Muthugama Thilini A. , Masakorala Jayanthi , Ramasinghe Ravija YC. , De Silva Aruna D. 
Published: December 2021

BackgroundMelioidosis is a potentially fatal infectious disease caused byBurkholderia pseudomalleiand the disease is endemic in Southeast Asia and Northern Australia. It has been confirmed as endemic in Sri Lanka. Genomic epidemiology ofB.pseudomalleiin Sri Lanka is largely unexplored. This study aims to determine the biogeography and genetic diversity of clinical isolates ofB.pseudomalleiand the phylogenetic and evolutionary relationship of Sri Lankan sequence types (STs) to those found in other endemic regions of Southeast Asia and Oceania.MethodsThe distribution of variably present genetic markers [Burkholderiaintracellular motility A (bimA)gene variantsbimABP/bimABM, filamentous hemagglutinin 3 (fhaB3),Yersinia-like fimbrial (YLF) andB.thailandensis-like flagellum and chemotaxis (BTFC) gene clusters and lipopolysaccharide O-antigen type A (LPS type A)] was examined among 310 strains. Multilocus sequence typing (MLST) was done for 84 clinical isolates. The phylogenetic and evolutionary relationship of Sri Lankan STs within Sri Lanka and in relation to those found in other endemic regions of Southeast Asia and Oceania were studied using e BURST, PHYLOViZ and minimum evolutionary analysis.ResultsThe Sri LankanB.pseudomalleipopulation contained a large proportion of the rare BTFC clade (14.5%) andbimABMallele variant (18.5%) with differential geographic distribution. GenotypesfhaB3 andLPSA were found in 80% and 86% respectively. This study reported 43 STs (including 22 novel). e-BURST analysis which include all Sri Lankan STs (71) resulted in four groups, with a large clonal group (group 1) having 46 STs, and 17 singletons. ST1137 was the commonest ST. Several STs were shared with India, Bangladesh and Cambodia.ConclusionThis study demonstrates the usefulness of high-resolution molecular typing to locate isolates within the broad geographical boundaries ofB.pseudomalleiat a global level and reveals that Sri Lankan isolates are intermediate between Southeast Asia and Oceania.
Evidence of Chikungunya virus seroprevalence in Myanmar among dengue-suspected patients and healthy volunteers in 2013, 2015, and 2018
Authors: Luvai Elizabeth Ajema Chebichi , Kyaw Aung Kyaw , Sabin Nundu Sabiti , Yu Fuxun , Hmone Saw Wut , Thant Kyaw Zin , Inoue Shingo , Morita Kouichi , Ngwe Tun Mya Myat 
Published: December 2021

Introduction
Chikungunya virus (CHIKV) is a mosquito-borne virus known to cause acute febrile illness associated with debilitating polyarthritis. In 2019, several institutions in Myanmar reported a CHIKV outbreak. There are no official reports of CHIKV cases between 2011 and 2018. Therefore, this study sought to determine the seroprevalence of CHIKV infection before the 2019 outbreak.

Methods
A total of 1,544 serum samples were collected from healthy volunteers and patients with febrile illnesses in Yangon, Mandalay, and the Myeik district in 2013, 2015, and 2018. Participants ranged from one month to 65 years of age. Antibody screening was performed with in-house anti-CHIKV IgG and IgM ELISA. A neutralization assay was used as a confirmatory test.

Results
The seroprevalence of anti-CHIKV IgM and anti-CHIKV IgG was 8.9% and 28.6%, respectively, with an overall seropositivity rate of 34.5%. A focus reduction neutralization assay confirmed 32.5% seroprevalence of CHIKV in the study population. Age, health status, and region were significantly associated with neutralizing antibodies (NAbs) and CHIKV seropositivity (p < 0.05), while gender was not (p = 0.9). Seroprevalence in 2013, 2015, and 2018 was 32.1%, 28.8%, and 37.3%, respectively. Of the clinical symptoms observed in participants with fevers, arthralgia was mainly noted in CHIKV-seropositive patients.

Conclusion
The findings in this study reveal the circulation of CHIKV in Myanmar’s Mandalay, Yangon, and Myeik regions before the 2019 CHIKV outbreak. As no treatment or vaccine for CHIKV exists, the virus must be monitored through systematic surveillance in Myanmar.
Effects of health education on adolescents’ non-cognitive skills, life satisfaction and aspirations, and health-related quality of life: A cluster-randomized controlled trial in Vietnam
Authors: Yoon Sangchul , An Shinki , Noh Dave Haeyun , Tuan Le Thanh , Lee Jongwook 
Published: December 2021

Objective
The effectiveness of health education on adolescents has been questioned, along with a growing body of empirical studies documenting the absence of behavioral changes after the intervention. However, evidence on its impact on other crucial health domains, besides health practices, is lacking. We evaluated the causal effects of a school-based health education program on adolescents’ multidimensional psychological health factors.

Design
A cluster-randomized controlled trial.

Methods
We conducted a cluster-randomized controlled trial involving 140 lower secondary schools in Vietnam. After stratifying by district, schools were randomized 1:1 to either treatment or control groups. Students enrolled in the treatment schools received monthly stand-alone health education in five topics by school teachers at the class level, but control group students did not receive any intervention. The primary outcomes of the study were students’ non-cognitive skills, life satisfaction, aspirations gap, and the Health-Related Quality of Life at five-month follow-up. We estimated the intention-to-treat effects with the panel fixed effects model using student panel data.

Results
Of the 6,477 students enrolled at baseline, 2,958 (92%) treated and 2,967 (91%) control students completed the follow-up survey five months after baseline data collection from October to December 2018. Compared with controls, health education led to improved treatment school students’ self-efficacy (p-value = 0.013), presumed life satisfaction five years from the present (p-value = 0.001), aspirations gap for a socially and mentally healthy future (p-value = 0.036), and the Health-Related Quality of Life (p-value = 0.036).

Conclusion
A school-based health education program enhanced students’ non-cognitive skills, life satisfaction and aspirations gap, and the Health-Related Quality of Life significantly. This study proposes essential psychological factors that should be taken into account when evaluating the effectiveness of a health education program in resource-limited settings.
Direct medical costs after surgical or nonsurgical treatment for degenerative lumbar spinal disease: A nationwide matched cohort study with a 10-year follow-up
Authors: Kim Chi Heon , Chung Chun Kee , Choi Yunhee , Lee Juhee , Yang Seung Heon , Lee Chang Hyun , Park Sung Bae , Kim Kyoung-Tae , Rhee John M. , Park Moon Soo 
Published: December 2021

Objective
The demand for treating degenerative lumbar spinal disease has been increasing, leading to increased utilization of medical resources. Thus, we need to understand how the budget of insurance is currently used. The objective of the present study is to overview the utilization of the National Health Insurance Service (NHIS) by providing the direct insured cost between patients receiving surgery and patients receiving nonsurgical treatment for degenerative lumbar disease.

Methods
The NHIS-National Sample Cohort was utilized to select patients with lumbar disc herniation, spinal stenosis, spondylolisthesis or spondylolysis. A matched cohort study design was used to show direct medical costs of surgery (n = 2,698) and nonsurgical (n = 2,698) cohorts. Non-surgical treatment included medication, physiotherapy, injection, and chiropractic. The monthly costs of the surgery cohort and nonsurgical cohort were presented at initial treatment, posttreatment 1, 3, 6, 9, and 12 months and yearly thereafter for 10 years.

Results
The characteristics and matching factors were well-balanced between the matched cohorts. Overall, surgery cohort spent $50.84/patient/month, while the nonsurgical cohort spent $29.34/patient/month (p<0.01). Initially, surgery treatment led to more charge to NHIS ($2,762) than nonsurgical treatment ($180.4) (p<0.01). Compared with the non-surgical cohort, the surgery cohort charged $33/month more for the first 3 months, charged less at 12 months, and charged approximately the same over the course of 10 years.

Conclusion
Surgical treatment initially led to more government reimbursement than nonsurgical treatment, but the charges during follow-up period were not different. The results of the present study should be interpreted in light of the costs of medical services, indirect costs, societal cost, quality of life and societal willingness to pay in each country. The monetary figures are implied to be actual economic costs but those in the reimbursement system instead reflect reimbursement charges from the government.
Medially positioned plate in first metatarsophalangeal joint arthrodesis
Authors: Witkowski Wojciech , Kuik Leszek , Rucka Magdalena , Daszkiewicz Karol , Andrzejewska Angela , Łuczkiewicz Piotr 
Published: December 2021

Objective
The purpose of this study was to biomechanically compare the stability of first metatarsophalangeal (MTP1) joint arthrodesis with dorsally and medially positioned plates.

Methods
A physical model of the MTP1 joint consists of printed synthetic bones, a titanium locking plate and screws. In the experiments, samples with dorsally and medially positioned plates were subjected to loading of ground load character in a universal testing machine. Force-displacement relations and relative displacements of bones were recorded. The obtained results were used to validate the corresponding finite element models of the MTP1 joint. Nonlinear finite element simulations of the toe-off phase of gait were performed to determine the deformation and stress state in the MTP1 joint for two positions of the plate.

Results
In numerical simulations, the maximum displacement in the dorsal direction was noticed at the tip of the distal phalanx and was equal to 19.6 mm for the dorsal plate and 9.63 mm for the medial plate for a resultant force of 150 N. Lower relative bone displacements and smaller plastic deformation in the plate were observed in the model with the medial plate. Stress values were also smaller in the medially positioned plate and locking screws compared to fixation with the dorsal plate.

Conclusions
A medially positioned locking plate provides better stability of the MTP1 joint than a dorsally positioned plate due to greater vertical bending stiffness of the medial plate. Smaller relative bone displacements observed in fixation with the medial plate may be beneficial for the bone healing process. Moreover, lower stress values may decrease the risk of complications associated with hardware failure.