bluuebunny/crossref_metadata_2025_split huggingface dataset:
Naprapathy versus orthopaedic standard care for common musculoskeletal disorders: an 8-year follow-up of a pragmatic randomized controlled trial in Sweden
Authors: Lilje Stina , Eklund Andreas , Wykman Anders , Sundberg Tobias , Skillgate Eva 
Published: November 2021

AbstractBackgroundMusculoskeletal pain is among the most common reasons for seeking care, specialist competence for its treatment in primary care limited and waiting lists for orthopaedics often amongst the longest. Many referrals to orthopaedics do not concern disorders that benefit from surgery. Manual therapy is effective, yet not integrated in national health care systems, and there is a lack of research on other than neck and low back pain, and a lack of long-term follow-ups.The present study evaluates the long-term effects of a manual therapy (naprapathy) for common orthopaedic disorders.MethodsAn 8-year follow-up (96 months) of a pragmatic randomized controlled trial of naprapathy (experimental group) versus standard orthopaedic care (control group) for non-surgical patients of working age with the most common musculoskeletal disorders on the waiting lists (n = 78). Bodily pain, physical function (SF36), Quality of life (QoL; SF6D), and data on health care utilization were collected. The treatments lasted from January 2007 to November 2007.ResultsN = 75 participants in the original study sample completed the 8-year follow-up. The differences in bodily pain (21.7 (95% CI: 9.1–34.3)), physical function (17.6 (6.7–28.4)), and QoLs (0.823 (95% CI: 0.785–0.862) compared with 0.713 (95% CI: 0.668–0.758)) were statistically significantly in favor of the experimental group (p-values < 0.01). After sensitivity analysis the experimental group had altogether 260 health care visits compared with 1161 in the control group.ConclusionsNaprapathy is a continuously effective treatment. Together with earlier research our study suggests that specialized manual therapy should be considered when triaging patients with common non-surgical musculoskeletal disorders in national health care systems.Trial registration: Not applicable, as per information given by ClinicalTrials.gov.
Cotton stubble detection based on wavelet decomposition and texture features
Authors: Yang Yukun , Nie Jing , Kan Za , Yang Shuo , Zhao Hangxing , Li Jingbin 
Published: November 2021

AbstractBackgroundAt present, the residual film pollution in cotton fields is crucial. The commonly used recycling method is the manual-driven recycling machine, which is heavy and time-consuming. The development of a visual navigation system for the recovery of residual film is conducive, in order to improve the work efficiency. The key technology in the visual navigation system is the cotton stubble detection. A successful cotton stubble detection can ensure the stability and reliability of the visual navigation system.MethodsFirstly, it extracts the three types of texture features of GLCM, GLRLM and LBP, from the three types of images of stubbles, residual films and broken leaves between rows. It then builds three classifiers: Random Forest, Back Propagation Neural Network and Support Vector Machine in order to classify the sample images. Finally, the possibility of improving the classification accuracy using the texture features extracted from the wavelet decomposition coefficients, is discussed.ResultsThe experiment proves that the GLCM texture feature of the original image has the best performance under the Back Propagation Neural Network classifier. As for the different wavelet bases, the vertical coefficient texture feature of coif3 wavelet decomposition, combined with the texture feature of the original image, is the feature having the best classification effect. Compared with the original image texture features, the classification accuracy is increased by 3.8%, the sensitivity is increased by 4.8%, and the specificity is increased by 1.2%.ConclusionsThe algorithm can complete the task of stubble detection in different locations, different periods and abnormal driving conditions, which shows that the wavelet coefficient texture feature combined with the original image texture feature is a useful fusion feature for detecting stubble and can provide a reference for different crop stubble detection.
A systematic literature review of frequency of vaso-occlusive crises in sickle cell disease
Authors: Zaidi Ahmar U. , Glaros Alexander K. , Lee Soyon , Wang Taiji , Bhojwani Rhea , Morris Eric , Donohue Breanne , Paulose Jincy , Iorga Şerban R. , Nellesen Dave 
Published: November 2021

Abstract
Background and purpose
Sickle cell disease (SCD) is a collection of rare inherited blood disorders affecting approximately 100,000 people in the U.S. and 20–25 million people globally. Individuals with SCD experience recurrent episodes of severe and unpredictable pain that are caused by vaso-occlusive crises (VOCs), a hallmark of the disease. VOCs are the primary cause of hospitalization in SCD, result in missed workdays and school days, and decrease quality of life (QoL). Although VOCs cause significant burden in the lives of individuals with SCD, there is no synthesis on the frequency of VOCs in the real world. This systematic literature review sought to identify literature describing the frequency of VOCs experienced by individuals with SCD in real-world settings.

Methods
MEDLINE and 6 congresses were searched (date range: January 1, 2000 to June 30, 2020). Studies were reviewed independently by two researchers. Studies assessing frequency or prevalence of VOCs or VOC-related outcomes were included.

Results
Of 1438 studies identified in the search, 52 met pre-specified inclusion and exclusion criteria. Reported frequency of VOCs varied widely ranging from a mean or median of 0 VOCs/year to 18.2 VOCs/year. The proportion of patients experiencing ≥ 3 VOCs/year ranged from 4 to 67% and the proportion of patients experiencing ≥ 5 VOCs/year ranged from 18 to 59%. Measures of VOC severity were limited, with 13 studies considering frequency of complicated VOCs and only 1 study reporting duration of VOC episodes.

Conclusions
This is the first study to systematically assess published evidence pertaining to VOCs in real-world settings. Reported VOC frequency in real-world settings varied widely, with a majority of studies only considering VOCs managed in an inpatient or outpatient setting. Studies that considered VOCs managed at home reported a higher frequency of VOCs, suggesting that many studies may underestimate the frequency of VOCs. This systematic literature review (SLR) highlights the need for consistent reporting of (1) self-reported VOCs, including those managed at home, (2) definitions of VOCs, (3) complicated VOCs, and (4) duration of VOC episodes in literature.
Alterations in brain morphology by MRI in adults with neurofibromatosis 1
Authors: Wang Su , Mautner Victor-Felix , Buchert Ralph , Flibotte Stephane , Suppa Per , Friedman Jan M. , Heran Manraj K. S. 
Published: November 2021

AbstractObjectiveNeurofibromatosis 1 (NF1) is a rare autosomal dominant disease that causes the dysregulated growth of Schwann cells. Most reported studies of brain morphology in NF1 patients have included only children, and clinical implications of the observed changes later in life remain unclear. In this study, we used MRI to characterize brain morphology in adults with NF1.MethodsPlanar (2D) MRI measurements of 29 intracranial structures were compared in 389 adults with NF1 and 112 age- and sex-matched unaffected control subjects. The 2D measurements were correlated with volumetric (3D) brain measurements in 99 of the adults with NF1 to help interpret the 2D findings. A subset (n = 70) of these NF1 patients also received psychometric testing for attention deficits and IQ and was assessed for clinical severity of NF1 features and neurological problems. Correlation analysis was performed between the MRI measurements and clinical and psychometric features of these patients.ResultsFour of nine corpus callosum measurements were significantly greater in adults with NF1 than in sex- and age-matched controls. All seven brainstem measurements were significantly greater in adults with NF1 than in controls. Increased corpus callosum and brainstem 2D morphology were correlated with increased total white matter volume among the NF1 patients. No robust correlations were observed between the 2D size of these structures and clinical or neuropsychometric assessments.ConclusionOur findings are consistent with the hypothesis that dysregulation of brain myelin production is an important manifestation of NF1 in adults.
Clinical and molecular spectrum of P/Q type calcium channel Cav2.1 in epileptic patients
Authors: Alehabib Elham , Esmaeilizadeh Zahra , Ranji-Burachaloo Sakineh , Tafakhori Abbas , Darvish Hossein , Movafagh Abolfazl 
Published: November 2021

AbstractBackgroundEpilepsy is a neurological disorder characterized by the potential to induce seizure and accompanied by cognitive, psychological, and social consequences.CACNA1Agene is a voltage-gated P/Q-type Cav2.1 channel that is broadly expressed in the central nervous system, and the pathogenic variants within this gene may be associated with the epileptic phenotype. In the present study, we collected clinical and molecular data related to epileptic patients withCACNA1Apathogenic variants and investigated possible meaningful relationship between age at onset, neurodevelopmental disorders, type of seizures, brain imaging abnormalities, genotype, and protein domains.ResultsIn our retrospective literature studies, from among 890 articles reviewed, a total of 90 individuals were related to epilepsy phenotype. Our findings showed that about 90 percent of patients have shown the first symptoms in childhood and teenage years and different types of neurodevelopmental disorders, such as intellectual disability, developmental arrest, and behavioral disorders, have been common findings for these patients. Further, a wide range of abnormalities have been observed in their brain imaging, and generalized seizures have been the most type of seizures in these patients. However, our data showed no specific genotype–phenotype correlation in epileptic patients withCACNA1Apathogenic alterations.ConclusionsOur study focused on epileptic phenotype in patients withCACNA1Apathogenic variants and showed a wide range of clinical and molecular heterogeneity with no specific genotype–phenotype correlation. It seems that incomplete penetrance,de-novovariants, and modifier genes are obstacles in predicting the clinical outcome.
A non-internalised CD38-binding radiolabelled single-domain antibody fragment to monitor and treat multiple myeloma
Authors: Duray Elodie , Lejeune Margaux , Baron Frederic , Beguin Yves , Devoogdt Nick , Krasniqi Ahmet , Lauwers Yoline , Zhao Yong Juan , D’Huyvetter Matthias , Dumoulin Mireille , Caers Jo 
Published: November 2021

Abstract
Background
Antibody-based therapies targeting CD38 are currently used as single agents as well as in combination regimens for multiple myeloma, a malignant plasma cell disorder. In this study, we aimed to develop anti-CD38 single-domain antibodies (sdAbs) that can be used to trace CD38+ tumour cells and subsequently used for targeted radionuclide therapy. SdAbs are derived from Camelidae heavy-chain antibodies and have emerged as promising theranostic agents due to their favourable pharmacological properties.

Methods
Four different anti-CD38 sdAbs were produced, and their binding affinities and potential competition with the monoclonal antibody daratumumab were tested using biolayer interferometry. Their binding kinetics and potential cell internalisation were further studied after radiolabelling with the diagnostic radioisotope Indium-111. The resulting radiotracers were evaluated in vivo for their tumour-targeting potential and biodistribution through single-photon emission computed tomography (SPECT/CT) imaging and serial dissections. Finally, therapeutic efficacy of a lead anti-CD38 sdAb, radiolabelled with the therapeutic radioisotope Lutetium-177, was evaluated in a CD38+ MM xenograft model.

Results
We retained anti-CD38 sdAb #2F8 as lead based on its excellent affinity and superior stability, the absence of competition with daratumumab and the lack of receptor-mediated internalisation. When intravenously administered to tumour-xenografted mice, radiolabelled sdAb #2F8 revealed specific and sustained tumour retention with low accumulation in other tissues, except kidneys, resulting in high tumour-to-normal tissue ratios. In a therapeutic setting, myeloma-bearing mice received three consecutive intravenous administrations of a high (18.5 MBq) or a low radioactive dose (9.3 MBq) of 177Lu-DTPA-2F8 or an equal volume of vehicle solution. A dose-dependent tumour regression was observed, which translated into a prolonged median survival from 43 days for vehicle-treated mice, to 62 days (p = 0.027) in mice receiving the low and 65 days in mice receiving the high (p = 0.0007) radioactive dose regimen, respectively.

Conclusions
These results highlight the theranostic potential of radiolabelled anti-CD38 sdAbs for the monitoring and treatment of multiple myeloma.
APOS—antibiotic prophylaxis for preventing infectious complications in orthognathic surgery: study protocol for a phase III, multicentre, randomised, controlled, double blinded, clinical trial with two parallel study arms
Authors: Ristow Oliver , Hofele Christof , Münch Philipp , Danner Sylvia , Dietzel Anja , Krisam Johannes , Klose Christina , Pilz Maximilian , Hoffmann Jürgen , Freudlsperger Christian 
Published: November 2021

Abstract
Background
It is a constant debate among surgeons whether the use of prolonged postoperative antibiotics may reduce surgical site infection rates. As specific treatment guidelines are still lacking, many surgeons continue to use broad-spectrum antibiotics, causing not only increased costs but also contributing to the potential for antibiotic resistance. Hence, there is an urgent need for an appropriately designed prospective clinical trial, to investigate whether a prophylactic use of antibiotics after surgery actually decreases surgical site infections to a clinically relevant degree.

Methods
This study presents a multicentre, randomised, controlled, double-blinded, clinical trial with two parallel study arms to demonstrate that no postoperative antibiotic prophylaxis (AP) is not inferior to antibiotic prophylaxis with respect to surgical site infections in patients having undergone orthognathic surgery. The primary efficacy endpoint is defined as the occurrence of postoperative surgical site infections within 30 days of surgery. Secondary endpoints are further efficacy and subject-oriented parameters within 90 days after surgery. The entire trial is planned for 54 months, with an enrolment of 1420 patients over 39 months by 14 national participating centres.

Discussion
As a highly standardised procedure on an exceeding, healthy and young homogenous study population and identical processes all over the world, elective orthognathic surgery as clean-contaminated procedure provides comparable intervention groups with balanced baseline characteristics, comparable surgical duration, even when performed within multiple centres. Therefore, evaluating antibiotic prophylaxis after orthognathic surgery will be of high scientific value representable for other surgical procedures.

Trial registration
DRKS—German Clinical Trials Register—DRKS00022838; EudraCT No. 2020-001397-30. Registered on 29 March 2021
Spread and scale of an electronic deprescribing software to improve health outcomes of older adults living in nursing homes: study protocol for a stepped wedge cluster randomized trial
Authors: Nadeau Marc-Eric , Henry Justine L. , Lee Todd C. , Bortolussi-Courval Émilie , Goodine Carole , McDonald Emily G. 
Published: November 2021

Abstract
Background
Medication overload or problematic polypharmacy is a major problem causing widespread harm, particularly to older adults. Taking multiple medications increases the risk of potentially inappropriate medications (PIMs), and residents in long-term care (LTC) are frequently prescribed 10 or more medications at once. One strategy to address this problem is for the physician and/or pharmacist to perform regular medication reviews; however, this process can be complicated and time-consuming. With a prescription review, medications may be decreased, changed, or stopped altogether. MedReviewRx is a software that runs an analysis using deprescribing rules to produce a report to guide medication reviews addressing medication overload for residents in LTC.

Methods
This study will employ a mixed methods effectiveness-implementation hybrid type 2 study design. To measure effectiveness, a stepped wedge cluster randomized trial design is planned, which allows us to approximate a randomized clinical trial. Approximately 1000 residents living in LTC will be recruited from five facilities in New Brunswick. The study will begin with 3 months of baseline data on rates of deprescribing. Thereafter, every 3 months a new cluster will enter the intervention mode. The intervention consists of medication reviews augmented with the MedReviewRx software, which will be used by staff and clinicians in the facilities. The estimated study duration is 18 months and the main outcome will be the proportion of patients with one or more PIMs deprescribed (reduced/stopped or changed to a safer alternative) in the 90 days following a prescription review. The goal is to study the impact of MedReviewRx on medication overload among older adults living in LTC. In typical fashion of a stepped wedge cluster randomized trial, each cluster acts as an internal control (before and after) as well as a control for the other clusters (external control). Qualitative data collected will include resident/caregiver attitudes towards deprescribing and semi-structured interviews with staff working in the long-term care homes.

Discussion
This study design addresses issues with seasonality and allows all clusters to participate in the intervention, which is an advantage when the intervention is related to quality improvement. This study will provide valuable information on PIM use, cost savings, and facilitators and challenges associated with medication reviews and deprescribing. This study represents an important step towards understanding and promoting tools to guide safe and rational reduction of PIM use among older adults.

Trial registration
NCT04762303, Registered February 21, 2021.
The importance of adherence to international standards for depositing open data in public repositories
Authors: Forero Diego A. , Curioso Walter H. , Patrinos George P. 
Published: November 2021

AbstractThere has been an important global interest in Open Science, which include open data and methods, in addition to open access publications. It has been proposed that public availability of raw data increases the value and the possibility of confirmation of scientific findings, in addition to the potential of reducing research waste. Availability of raw data in open repositories facilitates the adequate development of meta-analysis and the cumulative evaluation of evidence for specific topics. In this commentary, we discuss key elements about data sharing in open repositories and we invite researchers around the world to deposit their data in them.
Feasibility of home-based sampling of salivary cortisol and cortisone in healthy adults
Authors: Sørensen Sarah Overgaard , Pedersen Jesper , Rasmussen Martin G. , Kristensen Peter L. , Grøntved Anders 
Published: November 2021

Abstract
Objective
Salivary cortisol and cortisone are used as biomarkers of physiological stress. Careful sampling of saliva for profiling of awakening response and the diurnal slope can be challenging in free-living environments, and validated sampling protocols are lacking. Therefore, we investigated (1) the level of compliance to a three-day home-based salivary sampling protocol, and (2) the within subject day-to-day variability of cortisol and cortisone outcomes and the required measuring days to obtain high reproducibility.

Results
Nineteen healthy adults (mean age: 42, 50% females) participated. Participants collected in total 434 salivary samples out of 456 scheduled (four samples per day over three consecutive days at two time points). We found high level of compliance to the proposed free-living salivary sampling protocol with 18 (95%) and 16 (84%) participants being compliant to numbers and timing of samples, respectively. The area under the curve for the morning salivary samples and peak-to-bed slope had moderate reproducibility for cortisol and cortisone (intraclass correlation coefficient: 0.51–0.68, and mean coefficient of variation: 14.7%-75.3%). Three-to-four measuring days were required for high reproducibility of the area under the curve for the morning salivary samples and peak-to-bed slope using this free-living salivary sampling protocol.
Trial registration Clinical trial registered with www.clinicaltrials.gov (NCT03788525).
Placental extract suppresses the formation of fibrotic deposits by tumor necrosis factor alpha and transforming growth factor beta-induced epithelial–mesenchymal transition in ARPE-19 cells
Authors: Igarashi Kyoko , Sugimoto Koji , Hirano Eiichi 
Published: November 2021

Abstract
Objective
Epithelial–mesenchymal transition (EMT) is involved in the development of proliferative vitreoretinopathy (PVR) and subsequent fibrosis. Previously, we demonstrated that placental extract ameliorates fibrosis in a mouse model of non-alcoholic steatohepatitis. In this study, we evaluated whether placental extract influences EMT and fibrosis through cytokine-induced EMT in the retinal pigment epithelial cells, in vitro.

Results
Placental extract did not inhibit EMT, but it suppressed excessive mesenchymal reactions and the subsequent fibrosis. These results suggest that placental extract effectively ameliorates EMT-associated fibrosis in PVR. This beneficial effect could be partially attributed to the suppression of excessive mesenchymal reactions.
An open source library to parse and analyze online collaborative knowledge-building portals
Authors: Verma Amit Arjun , Iyengar S.R.S , Setia Simran , Dubey Neeru 
Published: November 2021

AbstractWith the success of collaborative knowledge-building portals, such as Wikipedia, Stack Overflow, Quora, and GitHub, a class of researchers is driven towards understanding the dynamics of knowledge building on these portals. Even though collaborative knowledge building portals are known to be better than expert-driven knowledge repositories, limited research has been performed to understand the knowledge building dynamics in the former. This is mainly due to two reasons; first, unavailability of the standard data representation format, second, lack of proper tools and libraries to analyze the knowledge building dynamics.We describe Knowledge Data Analysis and Processing Platform (KDAP), a programming toolkit that is easy to use and provides high-level operations for analysis of knowledge data. We propose Knowledge Markup Language (Knol-ML), a generic representation format for the data of collaborative knowledge building portals. KDAP can process the massive data of crowdsourced portals like Wikipedia and Stack Overflow efficiently. As a part of this toolkit, a data-dump of various collaborative knowledge building portals is published in Knol-ML format. The combination of Knol-ML and the proposed open-source library will help the knowledge building community to perform benchmark analysis.Link of the repository: Verma et al. (2020)Video Tutorial: Verma et al. (2020)Supplementary Material: Verma et al. (2020)