bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collagen Fibers-based Self-assembled 3D Spheroids Alleviate Thioacetamide-induced Liver Cirrhosis in Rats
Authors: Wu Yu Chiuan , Wu Guan Xuan , Chen Kuan Wei , Shiu Li-Yen , Kumar Satheesh , Liu Guei-Sheung , Kuo Shyh Ming 
Published: August 2021

Abstract
Cirrhosis refers to irreversible liver damage where healthy tissue is replaced by scar tissue which impairs liver function. There is no cure and current treatments only prevent further liver damage; thus novel therapeutic options are urgently needed. Here, we report a new approach that enables the formation of the self-assembled 3D spheroids of adipose-derived stem cells (ADSCs) and murine hepatocytes (AML12) via reconstituted collagen fibers. Compared with the spheroids formed in the commercially available EZSHERE dish, the collagen fiber-based ADSC/hepatocyte spheroids offer a notable benefit in structure formation and paracrine factor secretion. To test regenerative capability of the collagen fiber-based 3D ADSC/hepatocyte spheroids, a rat model of thioacetamide (TAA)-induced liver cirrhosis was employed. The transplantation of the collagen fiber-based 3D ADSC/hepatocyte spheroids show an improvement in liver function and ameliorates pathological liver cirrhosis in TAA-treated rats. In summary, our data show collagen fiber-based self-assembled 3D ADSC/hepatocyte spheroids to possess excellent regenerative capacity in response to TAA-induced liver injury, promising an alternative therapeutic strategy for liver cirrhosis.
The Effects of Laparoscopic Sleeve Gastrectomy on Biochemical and Hematological Parameters in Short Term; Retrospective Review of Laboratory and Radiological Findings
Authors: Akyol Hüseyin , Erok Berrin 
Published: August 2021

Abstract
Obesity, with its many associated diseases, is the fastest growing public health problem worldwide. Obesity related chronic inflammation is the main pathophysiological basis in many obesty related comorbidities. In obesity, hypertrophic growth of adipose tissue is associated with the stimulation of the secretion of inflammatory mediators such as tumor necrosis factor-alpha (TNF-a) and interleukin-6 (IL-6) (2, 3). Continued release of inflammatory mediators leads to chronic inflammation.Inflammatory markers such as neutrophil-lymphocyte ratio (NLR) and platelet / lymphocyte ratio (PLR), which are used as diagnostic and prognostic factors in infectious diseases, have been shown to play an important role in the prognostic evaluations in many diseases. The aim of this study is to retrospectively investigate the changes in these obesty related biochemical and hematological parameters 6 months after laparoscopic sleeve gastrectomy (LSG). In addition we also retrospectively reviewed the findings of abdominal ultrasonography (US) examinations in all patients and computed tomography (CT) findings in patients who had been performed, in terms of postoperative complications. In our study, the improvements in inflamatory markers in addition to glucose and lipid profiles have been showed with a possitive correlation parallel to the change in BMI.
Polygenic Risk Score Effectively Predicts Risk of Depression Onset in Alzheimer’s Disease
Authors: Upadhya Suraj , Liu Hongliang , Luo Sheng , Lutz Michael W. , Chiba-Falek Ornit 
Published: August 2021

Abstract
Introduction: Depression is a common, though heterogenous, comorbidity in late-onset Alzheimer’s Disease (LOAD) patients. In addition, individuals with depression are at greater risk to develop LOAD. In previous work, we demonstrated shared genetic etiology between depression and LOAD. Collectively, this evidence suggested interactions between depression and LOAD. However, the underpinning genetic heterogeneity of depression co-occurrence with LOAD is largely unknown.Methods: Major Depressive Disorder (MDD) genome wide association study (GWAS) summary statistics were used to create polygenic risk scores (PRS). The Religious Orders Society and Rush Memory and Aging Project (ROSMAP) and National Alzheimer’s Coordinating Center (NACC) datasets were utilized to assess the PRS performance in predicting depression onset in LOAD patients.Results: The developed PRS showed marginal results in standalone models for predicting depression onset in both ROSMAP (AUC=0.540) and NACC (AUC=0.534). Full models, with baseline age, sex, education, and APOEε4 allele count, showed improved prediction of depression onset (ROSMAP AUC: 0.606, NACC AUC: 0.583). In time-to-event analysis, standalone PRS models showed significant effects in ROSMAP (P=0.0051), but not in NACC cohort. Full models showed significant performance in predicting depression in LOAD for both datasets (P<0.001 for all).Discussion: This study provided new insights into the genetic factors contributing to depression onset in LOAD and advanced our knowledge of the genetics underlying the heterogeneity of depression in LOAD. The developed PRS accurately predicted LOAD patients with depressive symptoms, thus, has clinical implications including, diagnosis of LOAD patients at high-risk to develop depression for early anti-depressant treatment.
Natural Dye Extracted from Dalbergia cochinchinensis Residue with Water Fastness, Mildew Resistance and Permeability Properties for Wood Staining
Authors: Zhu Tao , Ren Kai , Sheng Jiale , Zhang Qiulong , Li Jian , Lin Jinguo 
Published: August 2021

Abstract
Wood dyed with extracts from Dalbergia cohinchinensis residues as natural dye (ND) exhibited desirable color appearance and anti-UV property while the potential property of the ND dyed wood has not been exploited with respect to the water fastness, mildew resistance along with the penetrability of the ND on wood blocks dyeing. The present study was aimed at exploring these aspects for multifunction assessment of the ND dyed wood. The results showed that the ΔE* (4.58) and color intensity reduction (PR:14.01%) of the ND dyed wood declined slightly after washed treatment by comparison with that of acid red (ΔE*:32.82; RP:76.14%) and reactive red (ΔE*:26.85; RP:66.52%) dyed wood indicative of its preferable waster fastness due to the surface hydrophobicity improvement. In addition, the ND ameliorated the mildew resistance against Aspergillus niger and Trichoderma viride infection. Interestingly, the wood blocks inner can be completely impregnated with ND under atmospheric pressure dyeing process without any pretreatment and auxiliary adding. The extracts utilization scenario was proved to perforce greatly promising for industrial application in terms of multifunctional ND dyed wood preparation.
Sec6 modulates PP2A phosphatase activity through alteration of the binding affinity of PP2A in A and C subunits
Authors: Tanaka Toshiaki , Iino Mitsuyoshi , Goto Kaoru 
Published: August 2021

Abstract
Dephosphorylation of the activated the regulator of a-fetoprotein (Raf)-MAP/ERK kinase (MEK)-the extracellular signal-regulated protein kinase (ERK)-p90 ribosomal protein 6 kinase (RSK) cascade plays an essential role in regulating the magnitude and duration of kinase activation and the nature of the physiological response. The protein phosphatase 2A (PP2A), which is one of the major serine/threonine phosphatases, plays a pivotal role in various signaling pathways including cell cycle, metabolism, migration, and cell death. The impairment of PP2A activity is associated with various diseases including neurodegenerative disorders, autoimmune diseases, type II diabetes, and tumors. However, little is known about how cells control the assembly of PP2A subunits and stabilize PP2A phosphatase activity. In the present study, we demonstrate that Sec6 regulates PP2A phosphatase activity by modulating the binding affinity of the A and C subunits of PP2A, thereby modulating the phosphorylation of p90RSK at Thr359 and Ser380, glycogen synthase kinase 3b (GSK3b) at Ser9, and the expression of zinc finger E-box binding homeobox 1 (ZEB1), vimentin, and zonula occludens 3 (ZO-3).
A new model of two-sown regime for oat forage production in an alpine region of northern China
Authors: Hou Longyu , Bai Wenming , Zhang Qiangqiang , Liu Yahong , Sun Hailian , Luo Yingluo , Song Shihuan , Zhang Wen-Hao 
Published: August 2021

Abstract
Demand for high forage production and quality of oat (Avena sativa L., A nuda L.) by animal husbandry has increased in recent years, especially in the cold regions of northern China, because these regions are the traditional animal husbandry base. To maximize high quality of forage production, we developed a new model of two-sown regime for oat forage during a single growing season in an alpine region of Hulun Buir, Inner Mongolia Autonomous Region, China, using two early-matured oat species, Avena sativa (cv. Qinghai444, winner oat cultivar) and A. nuda (cv. Huazao2, spring oat cultivar). The key technologies and corresponding mechanisms in the first spring-sown and the second summer-sown were studied by measuring agronomic characteristics and forage quality and production. Furthermore, forage production and quality, resources use efficiency, and economic benefits were compared and quantified between two-sown regime and traditional one-sown regime across three consecutive years (2017–2019). We found that 1) the first sowing in spring was done when the thawing depth of soil at 10–13 cm occurred, and the forage yield was mainly achieved by an increase in plant height; 2) The second sowing after harvesting the first sowing oat forage was made in summer under no-tillage treatment, with the yield being mainly due to an increase in tiller density by increasing seeding rate; 3) Compared to traditional one-sown regime, dry weight yield, crude protein yield and relative feed value were significantly increased by 53.6%, 48.9% and 70.6% across three experimental years of 2017–2019, respectively. These results clearly demonstrate that the two-sown regime of oat is an effectively way in improving forage production and quality as well as increasing benefits in an alpine region of northern China.
Prevalence of symptom-defined gastroesophageal reflux disease among general population of Herat, Afghanistan - A cross sectional study
Authors: Neyazi Ahmad , Jain Samarvir , Kaur Ekjot , Bhullar Khushman Kaur , Afzali Habibah , Noormohammadi Morteza , Momand Sabera , Mehmood Qasim 
Published: August 2021

Abstract
Background: Gastroesophageal Reflux Disease (GERD) is a chronic digestive ailment that is characterized by the regurgitation of stomach contents back into the esophagus. This cross-sectional study aims to estimate the prevalence of symptom-defined GERD and their correlation with age and BMI among the general population of Herat city, Afghanistan.Methods: This cross-sectional study was conducted among the general population of Herat city of Afghanistan from March 1st, 2021 to March 25th, 2021. A respective sample of 400 adults participated in this study. Different variables were collected using a questionnaire developed. Data were evaluated in the IBM SPSS program.Results: 61.8% of the participants were aged between 18 to 34 years old. 59.3% of the participant's body mass index (BMI) was found to be normal and healthy. 50.5% of the participants were male and 41.3% of the participants responded that they have digestive problems. 42.5% of the participants had heartburn, 31.5% of the participants responded that they usually experience stomach acid coming up. 32.5% of the participants said that they have chest pain while 36.8% of the participants responded that they have indigestion problems.Conclusion: The result of this study shows that the prevalence of symptoms-defined GERD among the general population of Herat province of Afghanistan is higher than in many countries in the world. A significant association was found between heartburn and chest pain with the age groups. Also, a significant association was found between the indigestion symptoms of GERD and the BMI of the participants.
ATITUDES E COMPORTAMENTOS DOS TRABALHADORES FACE ÀS TRANSFORMAÇÕES DO MUNDO DO TRABALHO SEGUNDO O MARXISMO ANALÍTICO OU INDIVIDUALISMO METODOLÓGICO
Authors: Lazzareschi Noêmia 
Published: August 2021

Este artigo tem como objetivo demonstrar que as atitudes e os comportamentos políticos, isto é, as estratégias de ação política dos trabalhadores para a defesa de seus interesses e a realização de suas expectativas, em todos os países industrializados do Ocidente, expressam clara compreensão do contexto histórico no qual surgem novas condições objetivas de trabalho e novas condições materiais de vida. Pretende-se, portanto, demonstrar, com fundamento na extensa bibliografia nacional e internacional sobre o mundo do trabalho e, especificamente, sobre o movimento sindical, que os trabalhadores elaboram formas de resistência que resultam de uma análise racional das condições dadas e das possibilidades de realização de seus objetivos e expectativas pessoais ou coletivos, a partir da qual tomam decisões estratégicas que definem o rumo de sua própria história. Assim, trata-se de se acompanhar, tal como indica o seu título, as atitudes e comportamentos dos trabalhadores face às transformações do mundo do trabalho que tipificaram as últimas décadas do século XX e estão revolucionando as primeiras décadas deste século, graças à utilização da inteligência artificial, blockchain, big data e profusão de aplicativos para a satisfação de um sem número de necessidades sociais, com a finalidade de indicar que resultaram sempre de uma escolha racional alternativas existentes, definindo a configuração da estrutura social da qual são os sujeitos.
A FORMAÇÃO DE UM GRUPO PROFISSIONAL
Authors: Garcia dos Santos Yumi , Georges Isabel 
Published: August 2021

Este artigo discute como as categorias gênero, classe e raça interferem (ou não) na formação de certos grupos profissionais, configurando a sua morfologia, a partir da análise de um estudo sobre agentes de execução de programas assistenciais brasileiros. É com base no conceito de consubstancialidade de gênero, classe e raça de Danièle Kergoat que é possível compreender as permanências e as mudanças que atravessam esse grupo profissional, que se encontra em baixa posição na hierarquia dos serviços públicos na saúde e na assistência contemporâneos. Numa abordagem inspirada no estudo das instituições do interacionismo norte-americano, a pesquisa propõe, por um lado, a análise das transformações da oferta institucional, assim como, pelo outro, das trajetórias socioprofissionais que a atravessam. São quatro agentes cujas experiências se apoiam em três contextos distintos da construção da política social: o primeiro, no final dos anos 1970, baseado no engajamento militante e comunitário de uma ex-agente sanitária ; o segundo, que se insere no processo de construção nacional da política de saúde voltada para as famílias no início de 2000, com o caso de duas agentes comunitárias de saúde. Uma delas carrega a herança da forma de trabalho comunitário e militante, e a outra se insere nesse mercado por motivos “instrumentais” para sobrevivência. O terceiro, por fim, um homem jovem, negro, se junta em nossa análise para compreender o sentido que ele atribui a esse trabalho fortemente feminizado, realizado num âmbito terceirizado e submetido a imperativos de produtividade.
Preservação Dos Contratos De Aprendizagem Profissional Em Tempos De Pandemia De Covid-19
Authors: Emerson Victor Hugo Costa de Sá  , Anderson Lincoln Vital da Silva  , Valena Jacob Chaves Mesquita  
Published: August 2021

O artigo analisa as estratégias de manutenção dos contratos de aprendizagem profissional em tempos de pandemia da COVID-19. Principal política pública voltada ao primeiro emprego, o instituto propicia oportunidades de formação técnico-profissional metódica para adolescentes e jovens, além de consistir em estratégia de erradicação do trabalho infantil. O cenário de crise de saúde pública, resultante do novo Coronavírus, gerou o reconhecimento do estado de calamidade pública em março de 2020, o que acarretou instabilidade nas relações jurídicas e a necessidade de adaptação normativa. Nesse contexto, analisa-se a aplicabilidade dos diplomas legais instituídos durante a crise sanitária decorrente da COVID-19, com especial ênfase na análise hermenêutica da Medida Provisória 926, cujos efeitos cessaram com a sua caducidade, e da Lei n. 14.020, de 6 de julho de 2020, fruto da conversão da Medida Provisória n. 936, notadamente quanto à preservação do trabalho do adolescente diante dessa nova realidade, por meio da aprendizagem e da qualificação profissionais em tempos de pandemia. A pesquisa utiliza o método de abordagem indutivo e apresenta-se como exploratória quanto aos objetivos, de natureza qualitativa e com base nos procedimentos bibliográfico e documental. Conclui-se que os contratos de aprendizagem se ajustaram para viabilizar a continuidade, mas há necessidade de marcos regulatórios mais precisos e atentos às especificidades do instituto, especialmente quanto ao público adolescente e o socialmente vulnerável.
PRODUÇÃO DE CURRÍCULOS MULTICULTURAIS E DECOLONIAIS NO CURSO DE PEDAGOGIA PELO CINEMA NEGRO DE ZÓZIMO BULBUL
Authors: Rosa Fabio Jose Paz 
Published: August 2021

Este artigo tem por objetivo apresentar a reconstrução de conhecimentos outros no curso de Pedagogia por meio do cinema negro de Zózimo Bulbul ao propor a exibição e a produção de atividades baseadas no filme Alma no olho. A fundamentação teórica respaldou-se no Paradigma Multicultural e nas Pedagogias decoloniais com o intuito de desenvolver conhecimentos para as diversidades enunciadas por meio do docente e dos estudantes participantes. As metodologias utilizadas foram a Pesquisa-ação e a Análise Criativa. Ao final, a investigação evidenciou a construção de conhecimentos propiciados pelas inter-relações corpóreas, estéticas e históricas do filme com as percepções e vivências dos graduandos.
Edifício e Cidade
Authors: Kennedy Braga Oliveira Fernando , Dos Santos Borda Luis Eduardo 
Published: August 2021

Este trabalho é parte de uma investigação mais ampla sobre a arquitetura de Oscar Niemeyer e sua abordagem enquanto signo. Ele foi desenvolvido como dissertação de mestrado no Programa de Pós Graduação da Faculdade de Arquitetura e Urbanismo e Design (PPGAU - FAUeD) da Universidade Federal de Uberlândia (UFU). Sua motivação partiu do desejo de exploração e síntese de algumas das teorias que se desdobram sobre a percepção visual e a organização da forma arquitetônica. Nesse sentido, o presente artigo se desdobra sobre a teoria da Gestalt - especificamente da Gestalt do Objeto de Gomes Filho (2009) - para entender as estratégias de organização do objeto arquitetônico em relação ao espaço urbano. Para tanto, a proposta consiste em uma leitura da Catedral de Brasília, projetada por Oscar Niemeyer. Acredita-se que esse exercício possa contribuir no entendimento de uma possível relação simbólica entre tal edifício e o espaço urbano.
Aktivitas Antibakteri Produk Polen Lebah terhadap Salmonella typhi NCTC786 BCC712
Authors: Milanda Tiana , Sjafril Astri K. , Sulistiyaningsih Sulistiyaningsih 
Published: August 2021

Polen lebahmerupakan serbuk sari bunga atau bagian tumbuhan lainnya yang dikumpulkan oleh lebah madu pejantan dari berbagai tumbuhan. Produk ini diketahui memiliki berbagai aktivitas farmakologi, diantaranya sebagai antimikroba terhadap beberapa bakteri Gram positif, Gram negatif dan jamur. Sampai saat ini, belum ada informasi mengenai aktivitas antibakteri polen lebah terhadap Salmonella typhi, penyebab demam tifoid pada manusia. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri beberapa produk polen lebah dari Kota Bandung, Jawa Barat, Indonesia terhadap S. typhi NCTC786 BCC712. Penelitian ini dilakukan melalui tahap pengujian aktivitas antibakteri produk polen lebah, penentuan nilai Konsentrasi Hambat Tumbuh Minimum (KHTM) dan Konsentrasi Bunuh Minimum (KBM) produk polen lebah teraktif dan penentuan nilai banding aktivitas antibakterinya terhadap kloramfenikol.Hasil penelitian menunjukkan ketiga produk mempunyai aktivitas antibakteri terhadap S. typhi NCTC786 BCC712, dengan aktivitas terbesar ditunjukkan oleh produk ketiga. KHTMdan KBM dari produk polen lebah terhadap S. typhi NCTC786 BCC712 masing-masing sebesar 137,5 mg/mL dan140 mg/mL.Nilai banding aktivitas antibakteri produk tersebut terhadap dengan kloramfenikol sebesar 1 : 0,0562. Hal ini menunjukkan aktivitas antibakteri produk polen lebah ketiga terhadap S. typhi NCTC786 BCC712 lebih lemah dibanding kloramfenikol.
Evaluation of diagnostic and prognostic usefulness of abdominal ultrasonography in dogs with clinical signs of acute pancreatitis
Authors: Gori Eleonora , Pierini Alessio , Lippi Ilaria , Citi Simonetta , Mannucci Tommaso , Marchetti Veronica 
Published: August 2021

Abstract

OBJECTIVE
To report abdominal ultrasonography (AUS) findings in dogs with clinical signs of acute pancreatitis (AP) during the first 2 days of hospitalization and to compare AUS findings with severity of disease and mortality rate.

ANIMALS
37 client-owned dogs with clinical signs of AP.

PROCEDURES
Dogs suspected of having AP with complete medical records, AUS examinations performed throughout the first 2 days of hospitalization, and available frozen surplus serum samples for quantitative measurement of canine pancreatic lipase (cPL) concentrations at hospital admission met the criteria for study inclusion. Dogs were grouped as AUS+ or AUS− on the basis of positive or negative findings for AP on AUS, respectively. Abdominal ultra-sonography findings of AP were stratified (as mild, moderate, or severe) by use of an AUS severity index, and a canine acute pancreatitis severity score was calculated.

RESULTS
24 of 37 (64.8%) dogs had AUS findings of AP at hospital admission, whereas 10 had positive findings for AP on AUS within 2 days of hospitalization. Three (8%) dogs were AUS− but had serum cPL concentrations > 400 µg/L (ie, values considered diagnostic for AP). On the AUS severity index, 5 of 34 (14.7%) AUS+ dogs had mild findings, 18 (52.9%) AUS+ dogs had moderate findings, and 11 (32.4%) AUS+ dogs had severe findings. Severe findings were associated with a higher risk of death than mild and moderate findings. A significant association was found between canine acute pancreatitis severity scores and mortality rates.

CONCLUSIONS AND CLINICAL RELEVANCE
For dogs with clinical signs of AP, repeated AUS examinations during hospitalization should be performed, severe findings on the AUS severity index may indicate an increased risk of death, and serum cPL concentrations may increase earlier than findings on AUS of AP.