bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility and acceptability of “active” classroom material among French university students and lecturers: a pilot study
Authors: Grosprêtre Sidney , Ennequin Gael , Peseux Sophie , Isacco Laurie 
Published: February 2021

Abstract
Background: Sedentary lifestyles are a plague of today's society in terms of physical, psychosocial and cognitive health. Students are particularly at risk because they spend most of their daily time sitting and inactive. The current pedagogical model must be rethought in order to promote their health, well-being and therefore their success. The objective of this project was to equip one classroom of the sport university with various active workstations (steppers, pedalboards, cycling desk, Swiss-ball, etc...) and to evaluate the feasibility and the influence of this type of material on cognitive and psychological factors of the students and to collect the feedback of lecturers during this experience. The global adherence to such material among students and lecturers also need to be assessed before generalizing the use of such material, which represent a certain cost for institutions. Methods: A total of 663 students and 14 lecturers took part in a survey that aims at evaluating various aspects of lecture’s quality after their first experience in the classroom. Results: The majority of students and lecturers reported positive effects of such material, by a reduction in fatigue, distraction and boredom. The most plebiscited materials were the cycling-desks and the swiss balls. Finally, 89.4 % of students were in favor of using active material in future lectures if they had the possibility to, as well as 71% of lecturers, demonstrating the global acceptance of such material. Conclusion: The present study brings promising results toward a more general implementation of such material in universities. Once a familiarization period is observed, such material in classroom could help prevent the deleterious effect of sedentary behavior as well as promoting a more active dailylife for the future workers represented by students.
Predialysis Serum Lactate Levels Can Predict Dialysis Withdrawal in Type 1 Cardiorenal Syndrome Patients
Authors: Pan Heng-Chih , Wu Vincent 
Published: February 2021

Abstract
Type 1 cardiorenal syndrome (CRS) is a complication with grave outcomes, and renal replacement therapy (RRT) is an effective rescue therapy. Serum lactate has been correlated with the risk of mortality in patients with sepsis. However, the association between serum lactate level and the prognosis of type 1 CRS patients requiring RRT is unknown. We prospectively enrolled 500 type 1 CRS patients who received RRT from August 2011 to January 2018. The 90-day mortality rate was 52.8% and the incidence rate of RRT independence was 34.8%. Lower pre-dialysis lactate was correlated with a higher rate of dialysis withdrawal and lower rate of mortality. A generalized additive model showed that 4.2 mmol/L was an adequate cut-off value of lactate to predict renal recovery. Taking mortality as a competing risk, Cox proportional hazards analysis indicated that a low lactate level (≦ 4.2 mmol/L) was an independent prognostic factor for the possibility of dialysis withdrawal, as also shown in external validation. The interaction of quick Sequential Organ Failure Assessment score and lactate was associated with dialysis dependence in a disease severity-dependent manner. In summary, we identified that pre-dialysis serum lactate level could predict the possibility of dialysis withdrawal in type 1 CRS patients.
Dietary and Plasmodium challenge effects on cuticular hydrocarbons in Anopheles albimanus
Authors: Claudio-Piedras Fabiola , Recio-Tótoro Benito , Cime-Castillo Jorge , Condé Renaud , Maffei Massimo , Lanz-Mendoza Humberto 
Published: February 2021

Abstract
The cuticular hydrocarbon (CHC) profile reflects the insect’s physiological states. These states include age, sex, reproductive stage, or gravidity. Environmental factors such as diet, relative humidity, or exposure to insecticides also affect the CHCs composition in mosquitoes. In this work, the CHC profile was analyzed in two Anopheles albimanus phenotypes with different degrees of susceptibility to Plasmodium: the susceptible-White and resistant-Brown phenotypes. The effects of the CHC profile were considered under a carbon-rich diet (sugar), a protein-rich diet (blood), and an infectious challenge (blood containing Plasmodium berghei ookinetes). The CHCs were analyzed by gas chromatography coupled with either mass spectrometry or flame ionization detection, identifying 19 CHCs with chain lengths ranging from 20 to 37 carbons. The qualitative and quantitative changes observed in the CHCs composition were dependent on the diet and parasite challenge, and independent of the phenotype. The exception was the challenged condition, where significant differences between the phenotypes were observed in Z-12 pentacosane, hexacosane 9-octyl, methyl-nonacosane, and methyl-hentriacontane. Since the lipid metabolism in Anopheles mosquitoes has been shown crucial for Plasmodium development, the changes in the CHC profiles associated with infection could have multiple effects on mosquito fitness and impacts on disease transmission.
Can Web Based Learning be the New Normal for the National Radiology Didactics in Singapore during COVID-19?
Authors: Seng Michael Che Hao , Sia Soon Yew , Wong Daniel , Liew Charlene Jin Yee , Sim Jocelyn Yan Fen , Lim Winston Eng Hoe 
Published: February 2021

Abstract
Objectives: The objective of this study aims to quantify and share the experiences of the residents and tutors during the transition to web-based learning during this time of COVID-19. Normally radiology residents would visit the different public hospitals to attend the different didactic teachings. However this is no longer possible and web-based learning has been implemented instead. Methods: Online anonymized surveys were given to the residents and tutors to gather feedback regarding the web-based learning exercise to help quantify the effectiveness of the sessions and to gather suggestions for improvement going forward. Results: The feedback from the web-based learning experience was generally positive from both the tutors and the residents and quality of learning was not compromised. Issues faced gradually improved as participants get more accustomed to web-based learning. The quality of learning also increased as tutors started to get more familiar and integrated their teaching material with the tools available in the software. Conclusions: As such, it is strongly recommended that the use of web-based learning should be considered the new norm going forward, even as the end of social distancing measures locally and worldwide remain uncertain.
Oral Manifestations of Patients with Systemic Sclerosis: A Meta-analysis for Case-controlled Studies.
Authors: Zhang Suhan , Zhu Junfei , Zhu Yanshan , Li Siying , Zhang Xiaochao , Wu Ruifang , Su Yuwen 
Published: February 2021

Abstract
Background：Systemic sclerosis (SSc) is a multisystem rheumatic disease. Orofacial manifestations are commonly in SSc but maybe usually ignored and overshadowed by other systemic complications. Multiple comparative studies have been conducted to investigate the possible links between SSc and oral manifestations. The present study aimed to investigate the oral health status in patients with SSc. Methods：Pubmed, Embase, Web of Science, and Scopus were searched up to July 2020. Following outcomes were evaluated: Probing depth (PD), Attachment loss (AL), Bleeding on probing (BOP), Number or percentage of Sites with PD ≥ 4 mm, Prevalence of periodontitis, Number of teeth, Decayed Teeth, Missing teeth, Filled teeth, DMFT index, and the interincisal distance. Newcastle-Ottawa Scale (NOS) were applied for quality assessment. The statistical analysis was processed using the software STATA.Results: 11 eligible studies were included. The maximum interincisor distance was significantly restricted in SSc patients (SMD -1.061; 95%CI [-1.546, -0.576]; Z=4.29, P=0.000).The prevalence of Periodontitis (OR 7.007; 95%CI [3.529,13.915]; Z=5.56, P=0.000) , PD (SMD 3.101; 95%CI [1.374, 4.829]; Z=3.52, P=0.000), AL(SMD 2.584; 95%CI [0.321, 4.846]; Z=2.24, P=0.025) , sites with PD≥4mm (SMD 2.071 ; 95%CI [0.267, 3.875]; Z=2.25, P=0.024) and the number of decayed teeth (SMD, 0.186; 95%CI [0.007, 0.365]; Z= 2.04, P=0.041) were increased significantly in SSc population in comparison with the controls. Conclusions: SSc patients have limited mouth opening, higher periodontitis prevalence, and worse periodontal status, as well as an increased number of decayed teeth. Routinely oral hygiene instruction and initial periodontal treatment is recommended for SSc patients.
Sevoflurane and isoflurane inhibit KCl-induced, Rho kinase-mediated, and PI3K-participated vasoconstriction in aged diabetic rat aortas
Authors: Yang Shaozhong , Liu Yu , Huang Shanshan , Jin Feihong , Qi Feng 
Published: February 2021

Abstract
Background The mechanism of volatile anesthetics on vascular smooth muscle (VSM) contraction in diabetes mellitus (DM) remains unclear. The current study was designed to determine the effects of sevoflurane (SEVO) and isoflurane (ISO) on KCl induction. PI3K and Rho kinase participate in vasoconstriction in aged type 2 DM (T2DM) rats.Methods KCl-induced (60 mM) contractions were examined in endothelium -denuded aortic rings from aged T2DM Otsuka Long-Evans Tokushima Fatty (OLETF) rats (65–70 weeks old), control age-matched nondiabetic Long-Evans Tokushima Otsuka (LETO) rats and young Wistar rats (6–8 weeks old). The effects of SEVO and ISO on KCl-induced vasoconstriction, as well as those of LY294002 and Y27632, were measured in aortic rings from the three groups using an isometric force transducer.Results KCl induced rapid and continuous contraction of aortic smooth muscle in the three groups, and the contraction was more obvious in OLETF rats.SEVO and ISO inhibited KCl-induced vasoconstriction in a concentration-dependent manner and were suppressed by LY294002 (10 mM) and Y27632 (1 µM). SEVO had a stronger inhibitory effect on the aortas of young Wistar rats than ISO, especially at 2 MAC and 3 MAC (P<0.05). In aged rats, the inhibitory effect of ISO was stronger than that of SEVO, especially OLETF rats. There was no significant difference in the effects of different concentrations of ISO on arterial contraction among the three groups. However, the effects of 1 MAC SEVO on Wistar rats and 3 MAC SEVO on OLETF rats were noticeably and significantly different (P<0.05).Compared with the control condition, LY294002 and Y27632 had the most noticeable effect on the KCl-induced contraction of aortic rings in OLETF rats (P<0.01).Conclusion KCl significantly increased the rapid and sustained contraction of aortic rings in aged patients with T2DM. SEVO and ISO reduced vascular tension in the three groups to different degrees. ISO had a smaller inhibitory effect on young rats, and SEVO had a smaller inhibitory effect on aged rats. The mechanism of SEVO and ISO in vascular tension in T2DM is due to changes in PI3K and/or Rho kinase activity.
Efficacy and Safety of Remimazolam Besylate Versus Propofol during Hysteroscopy: Single‐centre Randomized Controlled Trial
Authors: Zhang Xiaoqiang , Li Shuang , Liu Jing 
Published: February 2021

Abstract
Background: Remimazolam besylate is a new type of benzodiazepine that has the characteristics of quick effects, short maintenance and recovery times, and no accumulation. Compound opioids can have a sedative effect in some endoscopic examinations. This trial was conducted to confirm the efficacy and safety of remimazolam besylate versus propofol during hysteroscopy.Methods: Patients undergoing hysteroscopy were randomly assigned to either the remimazolam (Group R, n=41) or the propofol group (Group P, n=41). Group R was administered an induction dosage of 0.2 mg/kg/min and a maintenance dosage of 1 mg/kg/h. Group P was started at 1.5-2.0 mg/kg propofol for up to 60-100 s and then maintained at 3.0-6.0 mg/kg/h. In both groups, remifentanil was infused using a target-controlled infusion system with a target concentration of 1.5 ng/ml and titrated during the procedure. The incidence rates of body movement and various adverse events in both groups were compared.Results: Eighty-two patients were included in this study. The incidence of adverse events in Group R (8.5%) was significantly lower than that in Group P (36.6%) (P < 0.05). Injection pain, postoperative dizziness and low SpO2 were the most common adverse events (P < 0.05). Compared with Group P patients, Group R patients recovered faster, had a shorter residence time in the PACU, and exhibited a higher quality of recovery (P < 0.05).Conclusion: Remimazolam besylate can provide safe and effective sedation for hysteroscopy. The depth of sedation is sufficient and effective, and the quality of recovery is high. Moreover, adverse events such as haemodynamic fluctuation, excessive sedation depth, low SpO2 and injection pain caused by propofol are largely avoided.Trial registrationThis study was approved by the Clinical Research Ethics Committee of Mengcheng County No.1 People's Hospital (2020MYL20003) and registered at http:// www.chictr.org.cn (15/09/2020, ChiCTR-2000038252). The study protocol is performed in the relevant guidelines.
Chlamydia trachomatis, Ureaplasma urealyticum and Mycoplasma hominis urogenital infections in patients with infertility. Results from a large cross-sectional study.
Authors: Paira Daniela Andrea , Molina Guillermo , Tissera Andrea Daniela , Olivera Carolina , Molina Rosa Isabel , Motrich Ruben Dario 
Published: February 2021

Abstract
Female and male infertility have been associated to Chlamydia trachomatis, Ureaplasma urealyticum and Mycoplasma hominis urogenital infections. However, evidence from large studies assessing their prevalence and putative associations in patients with infertility is still needed. The study design was a cross-sectional study including 1554 female and 3610 male patients with infertility in Cordoba, Argentina. In women, the prevalence of C. trachomatis, U. urealyticum and M. hominis urogenital infection was 4.3%, 31.1% and 12.1% whereas in men it was 5.8%, 19.2% and 5.3%, respectively. C. trachomatis infection was significantly more prevalent in men whereas U. urealyticum and M. hominis infections were more prevalent in women. Besides, C. trachomatis and U. urealyticum infections were significantly higher patients younger than 25 years. Moreover, U. urealyticum and M. hominis infections were associated to each other in either infertile women or men. Our data revealed that C. trachomatis, U. urealyticum and M. hominis are prevalent uropathogens in infertile patients. Of clinical importance, C. trachomatis and U. urealyticum infections were more prevalent in young patients whereas U. urealyticum and M. hominis are reciprocal risk factors of their co-infection. These results highlight the importance of including the screening of urogenital infections in the diagnostic workup of infertility.
Topical Betaxolol Hydrochloride for the Treatment of Superficial Infantile Hemangiomas: A Single Institutional Retrospective Study
Authors: Li Hong , Li Chen-Xi , Zhou Yu-Chuan , Gong Zhong-Cheng , Ling Bin 
Published: February 2021

Abstract
Background and Objectives:

Beta-blockers have gradually become an attractive option for the treatment of infantile hemangiomas (IHs). Topical application of beta-blockers is more preferred over oral administration since their potential systemic adverse effects. Besides timolol, as the mainstream medication for superficial IHs, however other types of beta-blockers are rarely reported. To develop a brand-new effective approach, in this present study, betaxolol as a topical treatment for IHs was specifically observed and recorded.
Methods

83 infants with superficial hemangiomas admitted to the First Affiliated Hospital of Xinjiang Medical University from January 2018 to May 2019 were all treated by topical application of betaxolol. The changeable indicators such as color, size, tension and thickness were monthly recorded and evaluated according to visual analog scales. Multi-factor analysis of variance (MANOVA) with repeated measurements and Kruskal-Wallis H nonparametric test were performed to compare the clinical effectiveness across different groups.
Results

After six months of treatment, 33.78% (25/74) got excellent results, 55.41% (41/74) had good response, 8.11% (6/74) had moderate response and 2.70% (2/74) had poor response respectively. During the whole procedure, neither local discomforts nor systemic complications had been found. There was no significant difference in gender and location of occurrence among groups (P > 0.05), while the effect of topical application of betaxolol was optimum in the children aged 0–3 months (P = 0.002). None of three age groups had statistically significant discrepancy of heart rate and blood pressure after accepting treatment (one month, P = 0.618; four months, P = 0.138; six months, P = 0.757).
Conclusions

Our study showed that topical administration of betaxolol was effective and well-tolerated for superficial IHs, particularly in the early proliferative stage. However, its safety and efficacy need continuous studies to be confirmed.
Determinants of Non-Disclosure to Sexual Partner among Human immune virus Infected Adults on Anti-Retroviral Therapy Follow-Up Care at North Shewa Zone public Hospitals in Oromia Region, Ethiopia, 2020.
Authors: Alemineh Tiliksew Liknaw , Shifraew Mengistu Benayew , Shibabaw Muluken Ayenew , Kebede Andualem Gezahegn , Birlie Mihretie Gedfew , Mulu Atsedemariam Andualem , Kidani Bekalu Bewketu 
Published: February 2021

Abstract
BackgroundHIV positive status non-disclosure to sexual partner remains challenging for the prevention and control of Human Immune Virus infection as it results in poor antiretroviral treatment adherence, high risk of transmission and limits women’s ability in the prevention of mother to child transmission. ObjectiveThe study tried to identify determinants of non-disclosure to sexual partner/s among Human immune virus infected Adult on Anti-Retroviral Therapy Follow-Up Care at North Shewa zone public Hospitals in Oromia Region, Ethiopia, 2020. MethodsA hospital based unmake case control study was conducted from December 1 to February 30/2020 among 378 (94 cases and 284 controls) Human immune virus infected adults on Anti-Retroviral Therapy Follow-Up Care at North Shewa zone public Hospitals in Oromia Region, Ethiopia, 2020. Epi data version 3.1 for data entry and SPSS version 25 for analysis were used. To find factors significantly associated with non-disclosure to sexual partner/s, Bivariable and Multivariable logistic regression analysis were done. ResultOf a total of 378 sampled study respondents, 369 were interviewed (92 cases and 277 controls) giving response rate of 97.5%. Among the study participants 39.3% (36 cases and 109 controls) were in the age group of 31-40 years and more than half of the respondents, 53.4% (61 cases and 136 controls) were females. Regarding educational and marital status, 39.3% (100 controls and 45 cases) were unable to read and write and 69.6% (211 controls and 46 cases) were married. Variables that showed significant association with non-disclosure to sexual partner were male sex (AOR: 0.25, 95% CI: 0.13-0.47), ART duration <36 months (AOR:2.13, 95% CI: 1.14-4.01), Being on WHO clinical staging one (AOR: 3.00, 95% CI: 1.26-7.12), Having more than one lifetime sexual partner (AOR: 0.46, 95% CI: 0.22-0.95) and not seeing person/s publically disclosed HIV status (AOR: 3.12, 95% CI: 1.47-6.65). Conclusions﻿This study endorsed that promoting public HIV disclosure and having one sexual partner helps disclosure to sexual partner/s. Deep and continuous HIV disclosure counseling service is needed for Female, for those being in WHO clinical staging one and ART duration <36 months.
MicroRNA 33 Potentially Participates in the Development of Goose Fatty Liver via Its Target Gene CROT
Authors: Lin Xiao , Xing Ya , Zhang Yihui , Dong Biao , zhao Minmeng , Wang Jian , Geng Tuoyu , Gong Daoqing , Zheng Yun , Liu Long 
Published: February 2021

Abstract
Background

Previous studies indicate that microRNA33 (miR-33) and its target gene, CROT, are implicated in hepatic lipid metabolism, but it is unclear whether miR-33 participates in the development of goose fatty liver via CROT.
Methods

The expression of miR-33 in goose fatty liver, muscle and fat tissues, as well as the mRNA and protein expression of CROT in goose fatty liver was determined by q-PCR or Western-blot. The targeting regulatory relationship between miR-33 and CROT in goose liver cells was validated by miR-33 overexpression and interference assays. The effects of miR-33 mimic and CROT overexpression on lipid deposition and the expression of downstream genes were determined in goose primary hepatocytes. The treatment of high concentrations of glucose and insulin was performed to determine their regulation on the expression of miR-33 and CROT in goose primary hepatocytes.
Results

Here, data showed that miR-33 expression was significantly increased in the liver, muscle and fat tissues of overfed geese. Consistently, miR-33 mimic promoted lipid deposition in goose primary hepatocytes. Moreover, the regulatory targeting relationship between miR-33 and CROT was validated in goose primary hepatocytes. Consistently, the mRNA and protein expression of CROT were significantly reduced in goose fatty liver. Interestingly, CROT overexpression could induce the expression of fatty acid oxidation associated genes including CRAT, PEX5, EHHADH, CAT and ACOT8 in goose primary hepatocytes, but only the expression of PEX5 was significantly inhibited in goose fatty liver. However, it seemed conflicting that CROT overexpression increased lipid deposition and reduced lipid peroxidation in goose primary hepatocytes. Additionally, high glucose inhibited miR-33 expression and induced CROT expression in goose primary hepatocytes.
Conclusions

These findings suggest that miR-33 potentially participates in the development of goose fatty liver via CROT, and that miR-33/CROT may partially mediate the effect of glucose in goose liver cells.
Graphitic-Phase C3N4 Nanosheets Combined with MnO2 Nanosheets for Sensitive Fluorescence Quenching Detection of Parathion-Methyl
Authors: Liu Bicheng , Wu Sihao , Peng Zoujun , Rui Jiahan , Qiu Ping 
Published: February 2021

Abstract
In this study, we have developed a sensitive approach to measure organophosphorus pesticides (OPs) using graphitic-phase C3N4 nanosheets (g-C3N4) combined with a nanomaterial-based quencher MnO2 nanosheets (MnO2 NS). Because MnO2 NS could quench the fluorescence of g-C3N4 via the inner-filter effect (IFE), the enzymatic hydrolysate (thiocholine, TCh) can efficiently trigger the decomposition of MnO2 nanosheets in the presence of acetylcholinesterase (AChE) and acetylthiocholine, resulting in the fluorescence recovery of g-C3N4. OPs, as inhibitors for AChE activity, can prevent the generation of TCh and decomposition of MnO2 nanosheets, accompanied by fluorescence quenching again. So the AChE-ATCh-MnO2-g-C3N4 system can be utilized to detect OPs quantitatively based on the g-C3N4 fluorescence. Under the optimum conditions, the linear range for the determination of parathion-methyl (PM) and 2,2-dichlorovinyl dimethyl phosphate (DDVP) were found in the range of 0.1-2.1 ng/mL with a limit of detection of 0.069 ng/mL, and 0.5-16 ng/mL with a limit of detection of 0.069 ng/mL, respectively. Finally, this method was exploited for the monitoring of PM in real samples. The advantages of the assay are user-friendly, easy-to-ease, cost-effective compared to sophisticated analytical instruments.