bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating tumor cells and circulating cancer stem cells and their detection by the method of flow cytometry
Authors: Pozniak T. A. , Hancharou A. Y. , Abashkin V. M. , Stanovaya A. I. , Prokhorov A. V. , Shcharbin D. G. 
Published: August 2021

This review describes the circulating cancer stem cells (CCSCs) and circulating tumor cells (CTCs). CCSCs are one of the main initiators of recurrent cancer and thus make them an important target for the development of new treatment methods. CTCs are relatively new biomarkers for the early diagnosis of metastasis. CTCs provide doctors with valuable information about each stages of cancer treatments: diagnostic of early-stage disease, early detection of recurrent cancer, the efficiency of chemotherapy, and makes it possible to select an individual sensitive drug.The most informative and frequently used markers for the detection of CSCs and CSCs were described. The mechanism of two models of tumor formation is considered: clonal and hierarchical. The known mechanisms of epithelial-mesenchymal transition of tumor cells are described. The most widely used specific cell surface markers for the detection and isolation of CTCs and CCSCs are described. The efficiency of a sensitive high-precision method of multicolor flow cytometry using specific fluorescent dye-labeled monoclonal antibodies for the detection of CCSCs and CTCs in the blood of cancer patients is analyzed. Detection of CTCs and CCSCs provides important information for the early diagnosis of metastasis and open a possibility to personalized treatment, and to monitoring of all stages cancers.
On the issue of systems of orientation and service in Fromm’s philosophy
Authors: Nagornaya T. V. 
Published: August 2021

Based upon the analysis of E. Fromm’s philosophical ideas the problem of man’s choice of the system of universal orientation is considered in interrelation with the individual development of the subject. The article shows the principal impossibility of personal growth with no regard to the ontological imperative foundations of human existence.In the work the concepts of “religiosity” and “faith” are being distinguished and deconstructed. For this purpose, the concept of “faith” is taken out of the traditionally religious context and is shown as the subject’s inner orientation modus in relation to the overall integrity. Systems of orientation diﬀer in the scale and capability of realization of human creativity in relation to the surrounding world and oneself. The choice of system depends on the personal maturity and the individual’s readiness to perceive yet implicit levels of being. Philosophical faith thus provides an opportunity to reveal the hidden, implicative orders of existence, and the human spirit is viewed upon as an active beginning to fulﬁll these new ontological dimensions into life.Conclusions are made about the correlation of human inner growth with the number of dimensions of being that can be embraced, processed and integrated. Switching to another center of orientation becomes possible only if profound changes take place in the whole person. This kind of “personal growth” requires not only understanding, but also inner strength. In this case, a higher and more productive form of understanding and orientation can give liberation from its lower form.
Studi Budaya Pada Eksistensi Pelayaran (7 Hari Kematian) di Desa Sukarema Lombok Timur
Authors: Husnayati Husnayati , Amar Syahrul , Zidni Zidni 
Published: August 2021

Kebudayaan memiliki bentuk tersendiri dalam suatu masyarakat. Di Desa Sukarema Lombok Timur terdapat kebiasaan masyarakt dalam menghormati keluarga yang sudah meninggal dunia yang disebut dengan kepercayaan pelayaran (7 hari kematian). Penelitian ini bertujuan untuk mengetahui asal usul dari kepercayaan pelayaran 7 hari kematian di Desa Sukarema, Penelitian ini menggunakan metode kualitatif. Tahapan pencarian sumber data dilakukan melalui observasi, wawancara, dan dokumentasi. Analisis yang digunakan dalam penelitian ini adalah analisis data bersifat induktif melalui tahaoan reduksi daya, penyajian data, dan penarikan kesimpulan. Asal usul kepercayaan pelayaran 7 hari kematian berasal dari nenek moyang masyarakat Sasak yang menjadi adat istiadat di desa Sukarema. Kebiasaan ini masih eksis sampai sekarang, karena pelayaran merupakan adat-istiadat yang diwariskan secara turun temurun oleh leluhur atau nenek moyang masyarakat desa Sukarena. Mereka sangat menjunjung tinggi adat istiadat nenek moyang yang sudah ada.
Optimalisasi Guru Menggunakan Quiz Creator dalam Meningkatkan Minat Belajar IPS Siswa di MTs. Sepit Lombok Timur
Authors: Herianto Irwan , Ferdianto Jujuk , Zidni Zidni 
Published: August 2021

Penelitian ini bertujuan untuk mengetahui dua hal yang mengarah kepada penggunaan media pembelajaran wondershare quiz creator, yaitu optimalisasi guru dalam proses pembelajaran, dan minat belajar IPS bagi siswa kelas VIIIb MTs. Al-amin NW Sepit. Penelitian ini menggunakan metode deskriptif dengan model analisis data Milles dan Huberman. Hasil penelitian menyimpulkan bahwa secara umum guru di MTs Al-amin NW Sepit tidak pernah menggunakan media pembelajaran IT dan khususnya bagi guru mata pelajaran IPS terpadu kelas VIIIb, Hal ini dikarenakan oleh beberapa faktor: (a) guru mata pelajaran IPS terpadu tidak mengenal media pembelajaran IT dalam hal ini wondershare quiz creator, (b) tidak adanya sarana yang menunjang pembelajaran menggunakan media pembelajaran IT seperti LCD, (c) keterbatasan informasi bagi guru dalam hal pengembagan media berbasis IT, dan (d) guru tidak pernah mengikuti pelatihan media pembelajaran. Hadirnya media pembelajaran wondershare quiz creator memberikan dampak yang positif terhadap proses pembelajaran baik itu yang dirasakan oleh guru maupun siswa. Bagi guru penggunaan media wondershare quiz creator dirasakan sangat bermanfaat, karena selama proses mengajar menggunakan media pembelajaran wondershare quiz creator guru dapat mengoptimalkan proses pembelajaran. Bagi siswa sendiri penggunaan media pembelajaran wondershare quiz creator dalam proses belajar dirasakan mampu meningkatkan minat belajar.
Escuela pública y COVID-19: dificultades sociofamiliares de educación en confinamiento
Authors: Fernández Sánchez María Jesús , Pérez Vera Lucía , Sánchez Herrera Susana 
Published: August 2021

La crisis derivada de la pandemia por COVID-19 ha provocado el cierre de los centros educativos, trasladando la enseñanza de la escuela a los hogares. La educación a distancia ha supuesto un reto para las familias que, en ocasiones, realizan un sobreesfuerzo para cumplir con las demandas escolares. Por ello, el principal objetivo de este estudio es explorar los factores concretos que dificultan la adaptación a la enseñanza no presencial de las familias del alumnado de Educación Primaria.
Con el propósito de responder al objetivo señalado, se han ejecutado análisis estadísticos a partir de las respuestas de 236 familiares de alumnos de escuelas públicas de nuestro país a un cuestionario, creado y validado ad hoc, como sistema cuantitativo de obtención de datos. Por otra parte, se ha llevado a cabo un análisis cualitativo de más de 600 comentarios emitidos por los 236 familiares a una pregunta de tipo abierto.
Los resultados reflejan que casi la mitad de las familias reconocen dificultades de adaptación a la enseñanza no presencial, existiendo falta de recursos, carencia de conocimientos y problemas organizativos que han generado sentimientos negativos. Estas dificultades se agravan en los hogares del alumnado con familiares desempleados durante el confinamiento.
Finalmente, se refleja la necesidad de la activación de actuaciones que fomenten la comunicación, escuela y familia, y que disminuyan la brecha digital por condiciones sociofamiliares.
PENGARUH INTELLECTUAL CAPITAL, LEVERAGE, PROFITABILITAS, DAN LIKUIDITAS TERHADAP NILAI PERUSAHAAN
Authors: Putri Azlin Shakila , Miftah Desrir 
Published: August 2021

The objective of this study is to analyze the influence of intellectual capital, leverage, profitability and liquidity on firm value. Firm value is measured by price to book value (PBV), leverage is measured by debt to equity ratio (DER), profitability by return on equity (ROE) and liquidity by current ratio (CR). This research method is a quantitative research with sampling using a purpose sampling technique based on predetermined characteristics as many as 9 pharmaceutical sub-sector companies listed on the Indonesia Stock Exchange for the period 2016 - 2019. The type of data used is secondary data and the analytical method used is panel data regression using Eviews. The results show that intellectual capital, leverage, profitability have a significant effect on firm value. However, liquidity has no effect on firm value.
Analisis Penerapan Frame Work IDEAS Menggunakan Parameter PEI Guna Menentukan Rancangan Posisi Kerja Operator di CV. Nipson Industrial Coating
Authors: Hidayat Arnas Rizkia , Hariastuti Ni Luh Putu 
Published: August 2021

Kinerja dari operator atau pekerja pada dasarnya mempengaruhi tingkat keoptimalan suatu pekerjaan.Seperti kondisi kerja, tempat kerja, dan postur kerja yang menjadi faktor utama untuk melakukan suatu pekerjaan. Kenyamanan dan keselamatan kerja pada dasarnya akan dipengaruhi oleh faktor-faktor tersebut. Tingkat keamanan dan kenyamanan pekerja yang buruk salah satunya akan mengakibatkan musculoskeletal disordes (MSDs) berupa cidera otot urat syaraf, urat daging, tulang, persendian tulang, tulang rawan yang disebabkan oleh aktivitas kerja.Untuk menganalisis postur kerja adalah dengan menggunakan konsep ergonomi, metode yang digunakan dalam analisa ini adalah Framework IDEAS (Identify, Design, Evaluate, Adapt,Sustain) metode ini berisikan langkah-langkah dari awal sampai akhir bagaimana mengidentifikasi masalah antara pekerja dengan lingkungan kerjanya lalu dibuat pemecahan masalahnya. Dalam hal ini digunakan softwareJack 8.2 untuk menganalisis postur kerja yang ada dengan parameter PEI (Posture Evaluation Index). CV. Nipson Industrial Coating memiliki penilaian terhadap kenyamanan dan keselamatan operator dalam bekerja di ruang produksi CV. Nipson Industrial Coating, semua operator yang ada di ruang produksi pasti memiliki potensi bahaya dalam beraktivitas, dimana semakin besar nilai PEI (Posture Evaluation Index) maka akan semakin besar potensi bahayanya.Kata Kunci : Ergonomi, Frame Work IDEAS, PEI
A theoretical study of the modified equal scalar and vector Manning-Rosen potential within the deformed Klein-Gordon and Schrödinger in RNCQM and NRNCQM symmetries
Authors: Maireche Abdelmadjid 
Published: August 2021

In this research work, within the framework of relativistic and nonrelativistic noncommutative quantum mechanics, the deformed Klein–Gordon and Schrödinger equations were solved with the modified equal vector scalar Manning-Rosen potential that has been of signiﬁcance interest in recent years using Bopp's shift method and standard perturbation theory in the first-order in the noncommutativity parameters in 3-dimensions noncommutative quantum mechanics. By employing the improved approximation of the centrifugal term, the relativistic and nonrelativistic bound state energies were obtained for some diatomic molecules such as (HCl, CH, LiH, CO, NO, O2, I2, N2, H2, and Ar2). The obtained energy eigenvalues appear as a function of the generalized Gamma function, the parameters of noncommutativity, and the parameters of studied potential, in addition to the atomic quantum numbers . In both relativistic and nonrelativistic problems, we show that the corrections on the spectrum energy are smaller than the main energy in the ordinary cases of RQM and NRQM. A straightforward limit of our results to ordinary quantum mechanics shows that the present result is consistent with what is obtained in the literature. We have seen that the improved approximation of the centrifugal term is better than the other approximations in ﬁnding the approximate analytical solutions of the Klein-Gordon and Schrödinger equations for the modified Manning–Rosen potential in RNCQM and NRNCQM.
Acceptance matters: Disengagement and attrition among LGBT personnel in the U.S. military
Authors: McNamara Kathleen A. , Gribble Rachael , Sharp Marie-Louise , Alday Eva , Corletto Giselle , Lucas Carrie L. , Castro Carl A. , Fear Nicola T. , Goldbach Jeremy T. , Holloway Ian W. 
Published: August 2021

LAY SUMMARY The U.S. military has undergone several changes in policies toward lesbian, gay, bisexual, and transgender (LGBT) service members over the past decade. Some LGBT service members report continued victimization and fear of disclosing their LGBT identity, which can affect retention of LGBT personnel serving in the military. However, there is little research on this population. This study uses data from a survey funded by the U.S. Department of Defense (2017-2018) and completed by 544 active-duty service members (296 non-LGBT and 248 LGBT) to better understand the career intentions of LGBT service members. Of transgender service members, 33% plan to leave the military upon completion of their commitment, compared with 20% of cisgender LGB and 13% of non-LGBT service members. LGBT service members were twice as likely as non-LGBT service members to be undecided as to their military career path. Lower perceived acceptance of LGBT service members in the workplace was associated with a higher risk of leaving among LGBT service members. Lower perceived unit cohesion was associated with attrition risk for all members, regardless of LGBT status. These findings suggest that the U.S. military can do more to improve its climate of LGBT acceptance to prevent attrition.
Mind the gap: Sex, gender, and intersectionality in military-to-civilian transitions
Authors: Eichler Maya , Smith-Evans Kimberley , Spanner Leigh , Tam-Seto Linna 
Published: August 2021

LAY SUMMARYThe authors conducted a review of existing research on sex, gender, and intersectionality in relation to military-to-civilian transition (MCT). Extensive international studies and government resources, mostly from the United States, provide insight into the potential vulnerabilities and challenges encountered by historically under-represented military members and Veterans during MCT (i.e., by women, lesbian, gay, bisexual, transgender, and other sexual or gender minority, Black, Indigenous, and People of Colour military service members and Veterans). The reviewed sources also highlight government initiatives and tailored programs that exist internationally to address diverse Veteran needs. Canadian research and government initiatives on the topic are limited, and this gap needs to be kept in mind. To support equitable transition outcomes for all Veterans, research as well as policies, programs, and supports need to pay attention to sex and gender as well as intersecting factors such as sexuality, race, Indigeneity, and more.
Generalidades sobre encefalitis viral aguda
Authors: Pizarro Alvarado Gloriana , Garnier Fernández Juan Carlos , Orozco García Roberto 
Published: August 2021

La encefalitis es una inflamación del parénquima cerebral asociado a disfunción neurológica. Se suele presentar como un cuadro agudo o subagudo, con alteración del estado mental mayor de 24, fiebre, convulsiones, cefalea, y/o déficits neurológicos focales.
El Virus de herpes simple tipo 1 es la causa no epidémica más común de encefalitis infecciosa y la encefalitis japonesa es la causa más común de encefalitis infecciosa a nivel mundial. El pilar fundamental para el diagnóstico se basa en realizar una punción lumbar en la cual se observa pleocitosis linfocítica y se debe solicitar una PCR de manera urgente.
El tratamiento se basa en medidas de soporte asegurando la oxigenación, protección de las vías respiratorias, apoyo circulatorio, tratamiento de la pirexia y se recomienda iniciar de manera empírica con aciclovir intravenosa.
Actualización de lumbalgia en atención primaria
Authors: Dada Santos Michelle , Zarnowski Gutiérrez Andrés , Salazar Santiz Andrea 
Published: August 2021

La lumbalgia es un síntoma muy frecuente en la atención primaria, tanto en consulta externa como en el servicio de emergencias. Puede tener muchas causas, desde leves hasta severas. Sin embargo, en el 90% de los casos no se logrará encontrar una causa específica del dolor, esto se llamará lumbalgia mecánica.
Para un adecuado diagnóstico de la lumbalgia, se requiere de una anamnesis y un examen físico exhaustivo, esto nos ayudará a encontrar la etiología, descartar Banderas Rojas y dar un adecuado manejo.
El manejo de la lumbalgia mecánica se centrará en mejorar el dolor y la calidad de vida del paciente, también en disminuir los gastos en los servicios de salud. Para lograr esto el paciente se debe de proponer realizar ejercicios de estiramiento y fortalecimiento en el hogar, tomar el medicamento indicado y mantener una adecuada dieta y rutina de ejercicios. La labor del médico es tratar de impedir que la lumbalgia aguda evolucione a crónica, esto se logra con actividad física, evitando el reposo en cama, no suspendiendo labores, permaneciendo activo, descartando “banderas amarillas” y sobre todo no realizar estudios médicos innecesarios.
Supratentorial high-grade gliomas: maximal safe anatomical resection guided by augmented reality high-definition fiber tractography and fluorescein
Authors: Luzzi Sabino , Giotta Lucifero Alice , Martinelli Andrea , Maestro Mattia Del , Savioli Gabriele , Simoncelli Anna , Lafe Elvis , Preda Lorenzo , Galzio Renato 
Published: August 2021

OBJECTIVE
The theoretical advantages of augmented reality (AR) with diffusion tensor imaging (DTI)–based high-definition fiber tractography (HDFT) and sodium fluorescein (F) in high-grade glioma (HGG) surgery have not been investigated in detail. In this study, the authors aimed to evaluate the safety and efficacy profiles of HDFT-F microscope-based AR cytoreductive surgery for newly diagnosed supratentorial HGGs.

METHODS
Data of patients with newly diagnosed supratentorial HGGs who underwent surgery using the AR HDFT-F technique were reviewed and compared with those of a cohort of patients who underwent conventional white-light surgery assisted by infrared neuronavigation. The safety and efficacy of the techniques were reported based on the postoperative Neurological Assessment in Neuro-Oncology (NANO) scores, extent of resection (EOR), and Kaplan-Meier curves, respectively. The chi-square test was conducted for categorical variables. A p value < 0.05 was considered statistically significant.

RESULTS
A total of 54 patients underwent surgery using the AR HDFT-F technique, and 63 underwent conventional white-light surgery assisted by infrared neuronavigation. The mean postoperative NANO scores were 3.8 ± 2 and 5.2 ± 4 in the AR HDFT-F group and control group, respectively (p < 0.05). The EOR was higher in the AR HDFT-F group (p < 0.05) than in the control group. With a mean follow-up of 12.2 months, the rate of progression-free survival (PFS) was longer in the study group (log-rank test, p = 0.006) than in the control group. Moreover, the complication rates were 9.2% and 9.5% in the study and control groups, respectively.

CONCLUSIONS
Overall, AR HDFT-F–assisted surgery is safe and effective in maximizing the EOR and PFS rate for patients with newly diagnosed supratentorial HGGs, and in optimizing patient functional outcomes.
First in-human report of the clinical accuracy of thoracolumbar percutaneous pedicle screw placement using augmented reality guidance
Authors: Yahanda Alexander T. , Moore Emelia , Ray Wilson Z. , Pennicooke Brenton , Jennings Jack W. , Molina Camilo A. 
Published: August 2021

OBJECTIVE
Augmented reality (AR) is an emerging technology that has great potential for guiding the safe and accurate placement of spinal hardware, including percutaneous pedicle screws. The goal of this study was to assess the accuracy of 63 percutaneous pedicle screws placed at a single institution using an AR head-mounted display (ARHMD) system.

METHODS
Retrospective analyses were performed for 9 patients who underwent thoracic and/or lumbar percutaneous pedicle screw placement guided by ARHMD technology. Clinical accuracy was assessed via the Gertzbein-Robbins scale by the authors and by an independent musculoskeletal radiologist. Thoracic pedicle subanalysis was also performed to assess screw accuracy based on pedicle morphology.

RESULTS
Nine patients received thoracic or lumbar AR-guided percutaneous pedicle screws. The mean age at the time of surgery was 71.9 ± 11.5 years and the mean number of screws per patient was 7. Indications for surgery were spinal tumors (n = 4, 44.4%), degenerative disease (n = 3, 33.3%), spinal deformity (n = 1, 11.1%), and a combination of deformity and infection (n = 1, 11.1%). Presenting symptoms were most commonly low-back pain (n = 7, 77.8%) and lower-extremity weakness (n = 5, 55.6%), followed by radicular lower-extremity pain, loss of lower-extremity sensation, or incontinence/urinary retention (n = 3 each, 33.3%). In all, 63 screws were placed (32 thoracic, 31 lumbar). The accuracy for these screws was 100% overall; all screws were Gertzbein-Robbins grade A or B (96.8% grade A, 3.2% grade B). This accuracy was achieved in the thoracic spine regardless of pedicle cancellous bone morphology.

CONCLUSIONS
AR-guided surgery demonstrated a 100% accuracy rate for the insertion of 63 percutaneous pedicle screws in 9 patients (100% rate of Gertzbein-Robbins grade A or B screw placement). Using an ARHMS system for the placement of percutaneous pedicle screws showed promise, but further validation using a larger cohort of patients across multiple surgeons and institutions will help to determine the true accuracy enabled by this technology.
Kecurangan Akademik Dalam Perspektif Teori Fraud Diamond
Authors: Sofa Devi Maya , Susilowati Endah 
Published: August 2021

Academic fraud can occur in university because it is influenced by various underlying factors, both internally and externally. The purpose of holding this study was to determine whether the pressure, opportunity, rationalization, and abilities possessed by students significantly influence the occurrence of academic fraud in university. This research was conducted on 92 students of the Accounting Major in East Java "Veteran" National Development University by filling out a questionnaire via Google Form. The results of data collection were processed statistically using SmartPLS. The results of data analysis show that pressure, rationalization, and ability have a significant effect on academic fraud, while opportunities do not significantly influence students because lecturers always provide objective assessments to students, thereby reducing the chance of academic fraud.
Keywords: Diamond Fraud Theory, Academic Fraud