bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of water quality response to hypolimnetic anoxia in Daheiting Reservoir
Authors: Liu Chang , Wang Shiyan , Liu Xiaobo , Zhou Huaidong , Li Budong , Du Yanliang , Wang Liang 
Published: November 2021

Abstract
Anoxia is a common phenomenon at the bottom of large reservoirs during thermal stratification. In an anoxic environment, an increasing amount of reducing substances and nutrients are released and settle at the hypolimnion of the reservoir, leading to water quality deterioration and eutrophication. This work presents a case study on Daheiting Reservoir, a part of the Water Diversion Project from the Luanhe River to Tianjin city. With the monitored data of the water temperature and dissolved oxygen content in the reservoir, and based on the mechanism of redox reactions, the water quality response to the hypolimnetic anoxia in Daheiting Reservoir was systematically analyzed. It was found that the release of total phosphorus from the sediments in Daheiting Reservoir was a joint effect of the biological and chemical processes, and the redox reaction in the anoxic zone boosted release of phosphorus. Anoxia in the reservoir caused the ammonia nitrogen released from sediments in the reservoir to accumulate at the hypolimnion, which increased the concentration of ammonia nitrogen in the water. Anoxia in the reservoir led to an increase in the concentration of iron and manganese, which accounts for the major driving factor of release of iron and manganese.
Recent Trends in Rationally Designed Molecules as Kinase Inhibitors
Authors: Prasher Parteek , Sharma Mousmee , Chan Yinghan , Singh Sachin Kumar , Anand Krishnan , Dureja Harish , Jha Niraj Kumar , Gupta Gaurav , Zacconi Flavia , Chellappan Dinesh K. , Dua Kamal 
Published: November 2021

:
Protein kinases modulate the structure and function of proteins by adding phosphate
groups to threonine, tyrosine, and serine residues. The phosphorylation process mediated
by the kinases regulates several physiological processes, while their overexpression results
in the development of chronic diseases, including cancer. Targeting of receptor tyrosine
kinase pathways results in the inhibition of angiogenesis and cell proliferation that validates
kinases as a key target in the management of aggressive cancers. As such, the identification
of protein kinase inhibitors revolutionized the contemporary anticancer therapy by
inducing a paradigm shift in the management of disease pathogenesis. Contemporary drug
design programs focus on a broad range of kinase targets for the development of novel
pharmacophores to manage the overexpression of kinases and their pathophysiology in cancer
pathogenesis. In this review, we present the emerging trends in the development of rationally
designed molecular inhibitors of kinases over the last five years (2016-2021) and
their incipient role in the development of impending anticancer pharmaceuticals.
Recent Advances in the Synthesis of 5′-deoxynucleoside Phosphonate
Analogs
Authors: Shen Guang Huan , Hong Joon Hee 
Published: November 2021

:
The present review focuses on the synthesis of cyclic 5′-deoxynucleoside
phosphonate analogs. The formation of various phosphonate alkyl moieties is accomplished
through (i) Wittig (or HWE) type condensation to the nucleoside aldehyde moiety;
(ii) nucleophilic displacement reaction using phosphonate anion or Lewis acid; (iii)
Arbuzov reaction; (iv) olefin cross-metathesis between vinyl phosphonates and vinylated
nucleosides; and (v) radical reaction and Pd catalyzed alkyne. For the coupling of nucleobases
with cyclic moieties, the Mitsunobu reaction and Sonogashira-type cross-coupling
are usually applied. For the coupling of furanose moieties with nucleobases, Vorbrüggentype
condensation is generally applied. Addition reactions mediated by selenium ions are
mainly applied for the coupling of carbocyclic moieties. Their biological activity results
have been summarized.
Cholesterol in Brain Development and Perinatal Brain Injury: More than a Building Block
Authors: Lu Fuxin , Ferriero Donna M. , Jiang Xiangning 
Published: November 2021

:The central nervous system (CNS) is enriched with important classes of lipids, in which cholesterol is known to make up a major portion of myelin sheaths, besides being a structural and functional unit of CNS cell membranes. Unlike in the adult brain, where the cholesterol pool is relatively stable, cholesterol is synthesized and accumulated at the highest rate in the developing brain to meet the needs of rapid brain growth at this stage, which is also a critical period for neuroplasticity. In addition to its biophysical role in membrane organization, cholesterol is crucial for brain development due to its involvement in brain patterning, myelination, neuronal differentiation, and synaptogenesis. Thus any injuries to the immature brain that affect cholesterol homeostasis may have long-term adverse neurological consequences. In this review, we describe the unique features of brain cholesterol biosynthesis and metabolism, cholesterol trafficking between different cell types, and highlight cholesterol-dependent biological processes during brain maturation. We also discuss the association of impaired cholesterol homeostasis with several forms of perinatal brain disorders in term and preterm newborns, including hypoxic-ischemic encephalopathy. Strategies targeting the cholesterol pathways may open new avenues for the diagnosis and treatment of developmental brain injury.
Synthesis of Triazine Based Dendrimers: A Mini-Review
Authors: Singh Anupama , Kumari Sukhbeer 
Published: November 2021

Abstract:
Synthesizing s-triazine dendrimers are interesting as they can be synthesized easily, contain
diversity in composition, and have a basic potential for molecular recognition. Triazine trichloride is the
molecule of choice for synthesizing a novel class of dendrimers as it possesses certain remarkable characteristics
like the potential to expand the chemical functionality by nucleophilic aromatic substitution
reactions at various temperatures to give the desired dendrimer.
Multipotentiality of Luliconazole against Various Fungal Strains: Novel Topical Formulations and Patent Review
Authors: Mahajan Ayushi , Kaur Lakhvir , Singh Gurjeet , Dhawan Ravi Kumar , Singh Lovepreet 
Published: November 2021

Abstract:
Luliconazole is a broad-spectrum antifungal agent with impactful
fungicidal and fungistatic activity. It has shown exceptional potency against miscellaneous
fungal strains like Candida, Aspergillus, Malassezia, Fusarium species
and various dermatophytes. Luliconazole belongs to class II of the Biopharmaceutical
Classification System with low aqueous solubility. Although it is available
conventionally as 1% w/v topical cream, it has limitations of lower skin
permeation and shorter skin retention. Therefore, nanoformulations based on various
polymers and nanostructure carriers can be employed to overcome the impediments
regarding topical delivery and efficacy of luliconazole. In this review, we
have tried to provide insight into the literature gathered from authentic web resources
and research articles regarding recent research conducted on the subject
of formulation development, patents, and future research requisites of luliconazole.
Nanoformulations can play a fundamental role in improving topical delivery
by escalating dermal localization and skin penetration. Fabricating luliconazole
into nanoformulations can overcome the drawbacks and can efficiently enhance
its antimycotic activity. It has been concluded that luliconazole has exceptional
potential in the treatment of various fungal infections, and therefore, it
should be exploited to its maximum for its innovative application in the field of
mycology.
Foreign Direct Investment and Youth Employment Causality: Evidence From ASEAN-5 Countries
Authors: Setyanti Axellina Muara , Wahyudi Setyo Tri 
Published: November 2021

Abstract: FDI - employment relationship has been a major concern of many researchers due to it's various findings. FDI is stated that able to trigger growth in employment, however, on the other hand, some have found that employment conditions affect FDI inflow. Meanwhile, several studies found a bidirectional relationship, or even no-relationship. With a focus on youth employment, this study aimed to examine the link between FDI and youth employment in ASEAN-5 countries. From the results of the Granger Causality test, it was found that in Indonesia, Malaysia, Philippines, and Singapore the FDI inflow is leading to youth employment, while in Thailand, the relationship is vice versa. Overall, there is no bidirectional causal relationship between FDI and youth employment in ASEAN-5 countries.Keywords: Foreign Direct Investment, Youth Employment, Granger Causality, ASEAN-5 Kausalitas Penanaman Modal Asing dan Penyerapan Tenaga Kerja Muda: Bukti dari Negara-negara ASEAN-5Abstrak: Keterkaitan antara FDI dan penyerapan tenaga kerja telah menjadi perhatian utama banyak peneliti karena temuan yang beragam. FDI dinyatakan dapat memicu pertumbuhan lapangan kerja, namun di sisi lain, beberapa peneliti menemukan bahwa kondisi ketenagakerjaanlah yang mempengaruhi arus masuk FDI. Sementara itu, beberapa penelitian lain menemukan adanya hubungan dua arah, atau bahkan tidak ada hubungan. Dengan fokus pada penyerapan tenaga kerja muda, penelitian ini bertujuan untuk mengkaji hubungan antara FDI dan penyerapan tenaga kerja muda di negara-negara ASEAN-5. Dari hasil uji kausalitas Granger ditemukan bahwa di Indonesia, Malaysia, Filipina, dan Singapura, aliran FDI yang masuk mengarah pada pada penciptaan lapangan kerja bagi kaum muda, sedangkan di Thailand ditemukan hubungan yang sebaliknya. Secara keseluruhan, tidak ditemukan hubungan kausal dua arah antara FDI dan penyerapan tenaga kerja muda di negara-negara ASEAN-5.Kata kunci: Penanaman Modal Asing, Penyerapan Tenaga Kerja Muda, Kausalitas Granger, ASEAN-5
The Role of Board of Commissioners in Islamic Social Reporting
Authors: Ifada Luluk Muhimatul , Suhendi Chrisna , Hanafi Rustam 
Published: November 2021

Abstract: This research aims to investigate how the board of commissioners plays a role in influencing Islamic social reporting. The object of this study was the disclosure of Islamic social reporting in sharia banking in Indonesia, through secondary data. Data were analyzed using multiple linear regression analysis. The findings showed the role of the board of commissioners in influencing the extent of Islamic social reporting disclosure more likely through the size of the board of commissioners, not through an independent board of commissioners or the number of board meetings. Researchers found that challenge of a great opportunity for the board of commissioners to contribute to social responsibility of companies in accordance with the provisions of Islam. Keywords: Islamic social reporting, board of commissioners, sharia banks Peran Dewan Komisaris dalam Islamic Social ReportingAbstrak: Penelitian ini bertujuan untuk mengetahui peran dewan komisaris dalam mempengaruhi Islamic social reporting. Objek penelitian ini adalah pengungkapan Islamic social reporting pada perbankan syariah di Indonesia, melalui data sekunder. Analisis data menggunakan analisis regresi linier berganda. Temuan menunjukkan bahwa peran dewan komisaris dalam mempengaruhi pengungkapan Islamic social reporting cenderung melalui ukuran dewan komisaris, bukan melalui dewan komisaris independen atau jumlah rapat dewan. Peneliti menemukan bahwa terdapat tantangan yang menjadi peluang besar bagi dewan komisaris untuk berkontribusi pada tanggung jawab sosial perusahaan sesuai dengan ketentuan Islam.Kata kunci: Islamic social reporting, board of commissioners, bank syariah
Nocturnal Dipping and Left Ventricular Mass Index in the Chronic Kidney Disease in Children Cohort
Authors: Bakhoum Christine Y. , Katz Ronit , Samuels Joshua A. , Al-Rousan Tala , Furth Susan L. , Ix Joachim H. , Garimella Pranav S. 
Published: November 2021

Background and objectives
The physiologic nocturnal BP decline is often blunted in patients with CKD; however, the consequences of BP nondipping in children are largely unknown. Our objective was to determine risk factors for nondipping and to investigate if nondipping is associated with higher left ventricular mass index in children with CKD.

Design, setting, participants, & measurements
We conducted a cross-sectional analysis of ambulatory BP monitoring and echocardiographic data in participants of the Chronic Kidney Disease in Children study. Multivariable linear and spline regression analyses were used to evaluate the relationship of risk factors with dipping and of dipping with left ventricular mass index.

Results
Within 552 participants, mean age was 11 (±4) years, mean eGFR was 53 (±20) ml/min per 1.73 m2, and 41% were classified as nondippers. In participants with nonglomerular CKD, female sex and higher sodium intake were significantly associated with less systolic and diastolic dipping (P≤0.05). In those with glomerular CKD, Black race and greater proteinuria were significantly associated with less systolic and diastolic dipping (P≤0.05). Systolic dipping and diastolic dipping were not significantly associated with left ventricular mass index; however, in spline regression plots, diastolic dipping appeared to have a nonlinear relationship with left ventricular mass index. As compared with diastolic dipping of 20%–25%, dipping of <20% was associated with 1.41-g/m2.7-higher left ventricular mass index (95% confidence interval, −0.47 to 3.29), and dipping of >25% was associated with 1.98-g/m2.7-higher left ventricular mass index (95% confidence interval, −0.77 to 4.73), although these relationships did not achieve statistical significance.

Conclusions
Black race, female sex, and greater proteinuria and sodium intake were significantly associated with blunted dipping in children with CKD. We did not find a statistically significant association between dipping and left ventricular mass index.

Podcast
This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2021_12_20_CJN09810721.mp3
Strategic Diagnostics of the Industry as a Strategizing Object
Authors: Sasaev N. I. 
Published: November 2021

The changes associated with the strengthening of existing trends, the translation of global trends to regional and national levels, the emergence of new trends and their scaling up to the world level, leads to a transformation of conditions and the emergence of new strategic factors of economic development. This non-stationary process, which declares both negative and positive aspects, complicates the monitoring, search and selection of long-term guidelines for the industrial development of the economy, which justifies the relevance of the development of the methodological apparatus for strategizing industries.The industrial strategy developed in accordance with the general theory of strategy and the methodology of strategizing, the founder of which is Foreign Member of the Russian Academy of Sciences Vladimir L. Kvint, is designed to systematize and take into account the variability of conditions, the variety of strategic factors and emerging opportunities, decompose the latter to the level of strategic priorities, the implementation of which will generate high efficiency over the entire horizon of strategizing.At the same time, the general theory of strategy is a young science, being in constant contact with practice, the theoretical foundations and methodological provisions of its main directions, including industrial, are still at the stage of formation and improvement.Making correct and reasonable strategic decisions increasingly depends on the depth of studying the object of strategizing. In this regard, the purpose of this article was to disclose one of the preparatory stages for the development of a strategy, namely, the study of the industry as an object of strategizing.The article justifies the necessity of dividing the analysis of the industry as an object of strate-gizing into two stages: strategic diagnostics (the study of the main characteristics, features, the current trajectory of development and potential), and OTSW-analysis (the study of the object of industrial strategizing from the position of searching for future prospects, choosing a vector of long-term development and forming a trajectory of movement in the chosen direction). In addition, the author indicates the potential elements of strategic diagnostics of the industry as an object of strategizing and reveals the key aspects of each of the areas of analysis.
Bioplastiche: sono realmente così innocue?
Authors: Mastrolia Cristina 
Published: November 2021

Le bioplastiche, fin dal loro inserimento nei processi produttivi, sono
state considerate come una alternativa sicura ed ecosostenibile alle
“normali” plastiche (a base di petrolio) ree di danneggiare
invariabilmente l’ecosistema, in particolare quello marino. Di fatti, è
stimato che circa il 56% della plastica prodotta annualmente non venga
riciclata o incenerita, bensì venga scartata soprattutto negli oceani in
forma di microplastiche. Di conseguenza, la ricerca sulle bioplastiche e
specificamente sul loro ciclo vitale è un campo di studio di notevole
interesse ed in rapida crescita. Tuttavia, pensare alle bioplastiche
come la perfetta soluzione al problema dell’inquinamento da plastica
sarebbe un grossolano errore nonostante la loro produzione avvenga a
partire da fonti rinnovabili. Infatti, la maggior parte delle
bioplastiche sono biodegradabili ma non compostabili.
Il fine di questo lavoro è quindi quello di dare luce alla parte meno
conosciuta, e spesso ignorata, delle bioplastiche; ovvero il loro
potenziale dannoso sia durante la loro produzione, sia nei vari processi
di smaltimento, ed in particolare in ambiente marino; nonché
sull’applicazione del criterio e delle tecnologie di economia circolare
per il recupero, ed il riutilizzo delle bioplastiche all’interno degli
impianti di smaltimento delle acque reflue.
An Islamic Perspective on Peaceful Coexistence
Authors: Sulaiman Kabuye Uthman 
Published: November 2021

According to Abrahamic religions, namely Judaism, Christianity and Islam, human beings exist on the earth for a common purpose, and they have patrilineally and matrilineally descended from a single couple, namely Adam and Hawa (Eve). The Qur’an unambiguously mentions: “O mankind! reverence your Guardian-Lord, who created you from a single person, created, of like nature, His mate, and from them twain scattered (like seeds) countless men and women; reverence Allah, through whom ye demand your mutual (rights), and (reverence) the wombs (That bore you): for Allah ever watches over you.” Thus, it is incumbent upon human beings to live together in peace rather than constant hostility to fulfil the purpose of their existence on the earth. This paper endeavours to contribute to the understanding of the concept of ‘peaceful coexistence’ from the Islamic perspective. It specifically answers the following research questions: What is peaceful coexistence? What is necessary for peaceful coexistence? What are the fundamental principles that we must adhere to in order to coexist peacefully? The paper is structured into eight sections, beginning with introduction on the concept of ‘peace’ in Islam. The second section focuses on the main objectives of Islam. The third section is on the meaning of peaceful coexistence. The fourth and fifth sections are on the need for peaceful coexistence, and the necessary requirements and tools for peaceful coexistence respectively. The sixth section is on categorization of peaceful coexistence into: peaceful coexistence in marriage, peaceful coexistence of mankind, peaceful coexistence of the members of the Muslim ummah and peaceful coexistence of mankind and the environment. The seventh section is a summary of the Islamic principles of peaceful coexistence. The final section sums up the main conclusions drawn from this study. The translation of the ayat (verses) of the Qur’an related to this study is extracted from the work of Abdullah Yusuf Ali, The Holy Qur’an: Text and Translation unless stated otherwise. At the end of this paper, it is hoped that the readers will: first, appreciate the message of Islam as a universal religion and the need for mutual care, mutual respect, and mutual cooperation; and second, explore the methodology of the Qur’an and the Prophet Muhammad (peace and blessings be upon him) in managing human diversity. It is also hoped that this study will lead to a better understanding of peaceful coexistence as an integral part of Islam and one of the characteristics of the Muslim ummah. The findings of this study highlight the role of Islam in promoting peace and security. The study reveals that peaceful coexistence is a key factor in the success of human beings and it requires nurturing love, respect, care, and salam (a greeting of peace) in one’s relationship with others.
Opakowanie jako instrument promocji wioski tematycznej
Authors: LIPIŃSKA HALINA , GOLIASZ MAŁGORZATA , KORNAS RAFAŁ , GOLIASZ SYLWESTER 
Published: November 2021

W Polsce liczne obszary wiejskie nieustannie ulegają zmianom, zmienia się również mentalność ich mieszkańców. Stają się coraz bardziej świadomi, potrafią stworzyć ciekawą ofertę dla lokalnej społeczności, co wpisuje się w ideę trwałego, zrównoważonego i wielofunkcyjnego rozwoju obszarów wiejskich. Tworzona oferta staje się atrakcyjna również dla potencjalnych turystów, a jej kształtowanie odbywa się m.in. poprzez promowanie własnej miejscowości i budowanie wiosek tematycznych. Tego typu lokalna inicjatywa społeczno-gospodarcza powstała w Stężycy k. Dęblina. Koncentruje się ona na przedstawieniu lokalnego dorobku w nowej rzeczywistości, ale opartego na bazie miejscowej historii. Domeną dla miejscowych starań jest przywołanie dawnych zwyczajów szlacheckich jako wzoru gościnności na rzadko dziś spotykanym poziomie. Jednym z instrumentów promocji jest regionalne opakowanie ze skóry drobiowej, nadające się do produktów spożywczych. Przekaz ludowy kojarzony z kurczakiem służy propagowaniu dziedzictwa kulturowego i jest determinantem rozwoju lokalnego ruchu turystycznego.
Zawartość składników pokarmowych w mieszankach łubinu wąskolistnego z żytem jarym uprawianych na zieloną masę
Authors: MAKAREWICZ ARTUR , PŁAZA ANNA , GĄSIOROWSKA BARBARA , CYBULSKA ANNA 
Published: November 2021

Niedobór pasz objętościowych dla bydła mlecznego skłania do podjęcia badań nad uprawą mieszanek strączkowo-zbożowych z przeznaczeniem na zieloną masę. Do uprawy na glebach słabszych zaleca się mieszanki łubinu wąskolistnego z żytem jarym. W latach 2010–2012 w Rolniczej Stacji Doświadczalnej w Zawadach przeprowadzono badania nad określeniem wpływu składu i terminu zbioru na zawartość składników pokarmowych w mieszankach łubinu wąskolistnego z żytem jarym uprawianych na zieloną masę. W doświadczeniu badano dwa czynniki: skład mieszanek oraz termin zbioru. I. Skład mieszanek: łubin wąskolistny – siew czysty, żyto jare – siew czysty, łubin wąskolistny 75% + żyto jare 25%, łubin wąskolistny 50% + żyto jare 50%, łubin wąskolistny 25% + żyto jare 75%. II. Termin zbioru: faza kwitnienia łubinu wąskolistnego, faza płaskiego zielonego strąka łubinu wąskolistnego. W mieszankach uprawiano łubin wąskolistny odmiany Zeus i żyto jare odmiany Bojko. W pobranym materiale roślinnym oznaczono zawartość: białka ogólnego, tłuszczu surowego, włókna surowego i popiołu surowego. Na podstawie wykonanych oznaczeń zawartości składników pokarmowych obliczono zawartość związków bez- azotowych wyciągowych. Niezależnie od terminu zbioru największą zawartość białka ogólnego i popiołu surowego odnotowano w łubinie wąskolistnym uprawianym w siewie czystym, tłuszczu surowego w łubinie wąskolistnym oraz w mieszankach łubinu wąskolistnego z żytem jarym, a włókna surowego i związków bezazotowych wyciągowych w życie jarym uprawianym w siewie czystym. Mieszanki łubinu wąskolistnego z żytem jarym zebrane w fazie kwitnienia zawierały więcej białka ogólnego, popiołu surowego i bezazotowych związków wyciągowych, a zebrane w fazie płaskiego zielonego strąka łubinu wąskolistnego więcej tłuszczu surowego i włókna surowego.