bluuebunny/crossref_metadata_2025_split huggingface dataset:
Basic income and its applicability in Turkey
Authors: Çakmak Şahin Senem , Kılıç İbrahim Engin 
Published: November 2021

AbstractIn search of justice in income distribution and easy access to necessities by everyone, basic income (BI) has become one of the main topics of conversation. However, there is no comprehensive study on the cost and effect of BI in Turkey. This study aims to set a theoretical framework for BI, compare different views on the topic, evaluate implementations from the world, and analyze the feasibility of a BI program in Turkey by estimating its costs and distributional consequences using a tax–benefit microsimulation. The results show that, although it improves the income distribution, implementing a basic income scheme financed by income tax would impose a significant burden on the upper half of the income distribution due to widespread poverty and income inequality. In the baseline, individual-based scenario, every individual aged 15 or above is granted a BI equal to the poverty line, while children below age 15 are granted 30 percent of this amount. This plan costs 17.77 percent of the gross domestic product and it is covered by multiplying current income tax by 3.54. Implementation of this plan decreases the poverty rate from 12.43 percent to zero and the Gini index from 0.388 to 0.181.
Minmaxing of Bayesian Improved Surname Geocoding and Geography Level Ups in Predicting Race
Authors: Clark Jesse T. , Curiel John A. , Steelman Tyler S. 
Published: November 2021

AbstractRacial identification is a critical factor in understanding a multitude of important outcomes in many fields. However, inferring an individual’s race from ecological data is prone to bias and error. This process was only recently improved via Bayesian improved surname geocoding (BISG). With surname and geographic-based demographic data, it is possible to more accurately estimate individual racial identification than ever before. However, the level of geography used in this process varies widely. Whereas some existing work makes use of geocoding to place individuals in precise census blocks, a substantial portion either skips geocoding altogether or relies on estimation using surname or county-level analyses. Presently, the trade-offs of such variation are unknown. In this letter, we quantify those trade-offs through a validation of BISG on Georgia’s voter file using both geocoded and nongeocoded processes and introduce a new level of geography—ZIP codes—to this method. We find that when estimating the racial identification of White and Black voters, nongeocoded ZIP code-based estimates are acceptable alternatives. However, census blocks provide the most accurate estimations when imputing racial identification for Asian and Hispanic voters. Our results document the most efficient means to sequentially conduct BISG analysis to maximize racial identification estimation while simultaneously minimizing data missingness and bias.
Icebreaking polar class research vessels: New Antarctic fleet capabilities
Authors: Rogan-Finnemore Michelle , Ojeda Miguel , Paz Acosta Jorge Manuel , Bretel Patrice , Browne Nick , Flått Stig , Shuoren Wang , Sliester Randolph 
Published: November 2021

Abstract
Supporting Antarctic scientific investigation is the job of the national Antarctic programmes, the government entities charged with delivering their countries’ Antarctic research strategies. This requires sustained investment in people, innovative technologies, Antarctic infrastructures, and vessels with icebreaking capabilities. The recent endorsement of the International Maritime Organization (IMO) Polar Code (2015) means that countries must address challenges related to an ageing icebreaking vessel fleet. Many countries have recently invested in and begun, or completed, builds on new icebreaking Polar research vessels. These vessels incorporate innovative technologies to increase fuel efficiency, to reduce noise output, and to address ways to protect the Antarctic environment in their design. This paper is a result of a Council of Managers of National Antarctic Programs (COMNAP) project on new vessel builds which began in 2018. It considers the recent vessel builds of Australia’s RSV Nuyina, China’s MV Xue Long 2, France’s L’Astrolabe, Norway’s RV Kronprins Haakon, Peru’s BAP Carrasco, and the United Kingdom’s RRS Sir David Attenborough. The paper provides examples of purposeful consideration of science support requirements and environmental sustainability in vessel designs and operations.
Reduced emotion regulatory selection flexibility in post-traumatic stress disorder: converging performance-based evidence from two PTSD populations
Authors: Fine Naomi B. , Ben-Aharon Noa , Armon Daphna Bardin , Seligman Zivya , Helpman Liat , Bloch Miki , Hendler Talma , Sheppes Gal 
Published: November 2021

AbstractBackgroundContemporary views of emotion dysregulation in post-traumatic stress disorder (PTSD) highlight reduced ability to flexibly select regulatory strategies according to differing situational demands. However, empirical evidence of reduced regulatory selection flexibility in PTSD is lacking. Multiple studies show that healthy individuals demonstrate regulatory selection flexibility manifested in selecting attentional disengagement regulatory strategies (e.g. distraction) in high-intensity emotional contexts and selecting engagement meaning change strategies (e.g. reappraisal) in low-intensity contexts. Accordingly, we hypothesized that PTSD populations will show reduced regulatory selection flexibility manifested in diminished increase in distraction (over reappraisal) preference as intensity increases from low to high intensity.MethodsStudy 1 compared student participants with high (N = 22) post-traumatic symptoms (PTS, meeting the clinical cutoff for PTSD) and participants with low (N = 22) post-traumatic symptoms. Study 2 compared PTSD diagnosed women (N = 31) due to childhood sexual abuse and matched non-clinical women (N = 31). In both studies, participants completed a well-established regulatory selection flexibility performance-based paradigm that involves selecting between distraction and reappraisal to regulate negative emotional words of low and high intensity.ResultsBeyond demonstrating adequate psychometric properties, Study 1 confirmed that relative to the low PTS group, the high PTS group presented reduced regulatory selection flexibility (p = 0.01, $\eta _{\rm p}^2$ = 0.14). Study 2 critically extended findings of Study 1, in showing similar reduced regulatory selection flexibility in a diagnosed PTSD population, relative to a non-clinical population (p = 0.002, $\eta _{\rm p}^2$ = 0.114).ConclusionsTwo studies provide converging evidence for reduced emotion regulatory selection flexibility in two PTSD populations.
Long-term follow-up of subvalvular aortic stenosis in children: a single-centre experience
Authors: Ramoğlu Mehmet G. , Karagözlü Selen , Uçar Tayfun , Eyileten Zeynep , Uysalel Adnan , Atalay Semra , Tutar Ercan 
Published: November 2021

AbstractObjective:The aim of this study is to evaluate clinical and surgical outcomes of children with subaortic stenosis, to determine the risk factors for surgery and reoperation and to compare isolated subaortic stenosis and those concomitant with CHDs.Methods:The study involved 80 children with subaortic stenosis. The patients were first classified as isolated and CHD group, and the isolated group was further classified as membranous/fibromuscular group. The initial, pre-operative, post-operative and the most recent echocardiographic data, demographic properties and follow-up results of the groups were analysed and compared. The correlation of echocardiographic parameters with surgery and reoperation was evaluated.Results:There was a significant male predominance in all groups. The frequency of the membranous type was higher than the fibromuscular type in the whole and the CHD group. The median time to the first operation was 4.6 years. Thirty-five (43.7%) patients underwent surgery, 5 of 35 (14%) patients required reoperation. The rate of surgery was similar between groups, but reoperation was significantly higher in the isolated group. The gradient was the most important factor for surgery and reoperation in both groups. In the isolated group besides gradient, mitral-aortic separation was the only echocardiographic parameter correlated with surgery and reoperation.Conclusion:Reoperation is higher in isolated subaortic stenosis but similar in membranous and fibromuscular types. Early surgery may be beneficial in preventing aortic insufficiency but does not affect the rate of reoperation. Higher initial gradients are associated with adverse outcomes, recurrence and reoperation.
Altered Reinforcement Learning from Reward and Punishment in Anorexia Nervosa: Evidence from Computational Modeling
Authors: Wierenga Christina E. , Reilly Erin , Bischoff-Grethe Amanda , Kaye Walter H. , Brown Gregory G. 
Published: November 2021

ABSTRACTObjectives:Anorexia nervosa (AN) is associated with altered sensitivity to reward and punishment. Few studies have investigated whether this results in aberrant learning. The ability to learn from rewarding and aversive experiences is essential for flexibly adapting to changing environments, yet individuals with AN tend to demonstrate cognitive inflexibility, difficulty set-shifting and altered decision-making. Deficient reinforcement learning may contribute to repeated engagement in maladaptive behavior.Methods:This study investigated learning in AN using a probabilistic associative learning task that separated learning of stimuli via reward from learning via punishment. Forty-two individuals with Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 restricting-type AN were compared to 38 healthy controls (HCs). We applied computational models of reinforcement learning to assess group differences in learning, thought to be driven by violations in expectations, or prediction errors (PEs). Linear regression analyses examined whether learning parameters predicted BMI at discharge.Results:AN had lower learning rates than HC following both positive and negative PE (p < .02), and were less likely to exploit what they had learned. Negative PE on punishment trials predicted lower discharge BMI (p < .001), suggesting individuals with more negative expectancies about avoiding punishment had the poorest outcome.Conclusions:This is the first study to show lower rates of learning in AN following both positive and negative outcomes, with worse punishment learning predicting less weight gain. An inability to modify expectations about avoiding punishment might explain persistence of restricted eating despite negative consequences, and suggests that treatments that modify negative expectancy might be effective in reducing food avoidance in AN.
Investigation of field output factors using IAEA-AAPM TRS-483 code of practice recommendations and Monte Carlo simulation for 6 MV photon beams
Authors: Yabsantia Sumalee , Suriyapee Sivalee , Phaisangittisakul Nakorn , Oonsiri Sornjarod , Sanghangthum Taweap , Seuntjens Jan 
Published: November 2021

Abstract

Introduction:
This study aims to experimentally determine field output factors using the methodologies suggested by the IAEA-AAPM TRS-483 for small field dosimetry and compare with the calculation from Monte Carlo (MC) simulation.

Methods:
The IBA-CC01, Sun Nuclear EDGE and IBA-SFD detectors were employed to determine the uncorrected and the corrected field output factors for 6 MV photon beams. Measurements were performed at 100 cm source to axis distance, 10 cm depth in water, and the field sizes ranged from 1 × 1 to 10 × 10 cm2. The use of field output correction factors proposed by the TRS-483 was utilised to determine field output factors. The measured field output factors were compared to that calculated using the egs_chamber user code.

Results:
The decrease in the percentage standard deviation of the measured three detectors was observed after applying the field output correction factors. Measured field output factors using CC01 and EDGE detectors agreed with MC values within 3% for field sizes down to 1 × 1 cm2, except the SFD detector.

Conclusions:
The corrected field output factors agree with the calculation from MC, except the SFD detector. CC01 and EDGE are suitable for determining field output factors, while the SFD may need more implementation of the intermediate field method.
Conjugate Photoelectron Energy Spectra Derived From Coincident FUV and Radio Measurements
Authors: Urco J. M. , Kamalabadi F. , Kamaci U. , Harding B. J. , Frey H. U. , Mende S. B. , Huba J. D. , England S. L. , Immel T. J. 
Published: November 2021

AbstractWe present a method for estimating incident photoelectrons' energy spectra as a function of altitude by combining global scale far‐ultraviolet (FUV) and radio‐occultation (RO) measurements. This characterization provides timely insights important for accurate interpretation of ionospheric parameters inferred from the recently launched Ionospheric Connection Explorer (ICON) observations. Quantification of photoelectron impact is enabled by the fact that conjugate photoelectrons (CPEs) directly affect FUV airglow emissions but not RO measurements. We demonstrate a technique for estimation of photoelectron fluxes and their spectra by combining coincident ICON and COSMIC2 measurements and show that a significant fraction of ICON‐FUV measurements is affected by CPEs during the winter solstice. A comparison of estimated photoelectron fluxes with measured photoelectron spectra is used to gain further insights into the estimation method and reveals consistent values within 10–60 eV.
How the Source Depth of Coastal Upwelling Relates to Stratification and Wind
Authors: He Jing , Mahadevan Amala 
Published: November 2021

AbstractWind‐driven coastal upwelling is an important process that transports nutrients from the deep ocean to the surface, fueling biological productivity. To better understand what affects the upward transport of nutrients (and many other properties such as temperature, salinity, oxygen, and carbon), it is necessary to know the depth of source waters (i.e., “source depth”) or the density of source waters (“source density”). Here, we focus on the upwelling driven by offshore Ekman transport and present a scaling relation for the source depth and density by considering a balance between the wind‐driven upwelling and eddy‐driven restratification processes. The scaling suggests that the source depth varies as (τ/N)1/2, while the source density goes as (τ1/2N3/2), where τ is the wind stress and N is the stratification. We test these relations using numerical simulations of an idealized coastal upwelling front with varying constant wind forcing and initial stratification, and we find good agreement between the theory and numerical experiments. This work highlights the importance of considering stratification in wind‐driven upwelling dynamics, especially when thinking about how nutrient transport and primary production of coastal upwelling regions might change with increased ocean warming and stratification.
Stable Isotopes in Precipitation and Meteoric Water: Sourcing and Tracing the North American Monsoon in Arizona, New Mexico, and Utah
Authors: Tulley‐Cordova C. L. , Putman A. L. , Bowen G. J. 
Published: November 2021

AbstractThe North American Monsoon (NAM) is an important source of precipitation across the southwestern United States. The approximate northern boundary of this feature crosses the Navajo Nation (NN), in the Four Corners region, where NAM rains have long been important to the livelihoods of Native Americans. Relatively little is known about the characteristics and hydrological significance of the NAM in this region. Here, we report a new 4 yr record of stable H and O isotope ratios in monsoon‐season rainfall and water resources across the NN. Monthly precipitation samples collected at 39 sites document a characteristic pattern of 2H‐ and 18O‐enrichment associated with monsoonal precipitation. These changes are weakly correlated with local precipitation amount, however, and the correlation that does exist is dominated by sub‐cloud evaporation effects. In contrast to precipitation amount, monsoon‐season isotopic values exhibited little spatial variability across the region, and after correction for sub‐cloud evaporation NN values were similar to those from a site in southern Arizona. Airmass back trajectory analysis suggests that the uniformly high NAM precipitation water isotope ratios across the region may reflect (a) a region‐wide shift from mid‐latitude to low‐latitude moisture sources at the onset of the peak monsoon, and (b) substantial land‐surface recycling of NAM moisture in upwind regions. Comparison of precipitation water isotope data with surface and groundwater values implies that, despite its hydroclimatic significance, monsoon rainfall contributes little to subsurface water resources. This highlights the monsoon's importance for warm‐season land‐surface ecology and hydrology critical to residents in the Four Corners region.
Single cell-derived spheroids capture the self-renewing subpopulations of metastatic ovarian cancer
Authors: Velletri Tania , Villa Carlo Emanuele , Cilli Domenica , Barzaghi Bianca , Lo Riso Pietro , Lupia Michela , Luongo Raffaele , López-Tobón Alejandro , De Simone Marco , Bonnal Raoul J. P. , Marelli Luca , Piccolo Stefano , Colombo Nicoletta , Pagani Massimiliano , Cavallaro Ugo , Minucci Saverio , Testa Giuseppe 
Published: November 2021

AbstractHigh Grade Serous Ovarian cancer (HGSOC) is a major unmet need in oncology, due to its precocious dissemination and the lack of meaningful human models for the investigation of disease pathogenesis in a patient-specific manner. To overcome this roadblock, we present a new method to isolate and grow single cells directly from patients’ metastatic ascites, establishing the conditions for propagating them as 3D cultures that we refer to as single cell-derived metastatic ovarian cancer spheroids (sMOCS). By single cell RNA sequencing (scRNAseq) we define the cellular composition of metastatic ascites and trace its propagation in 2D and 3D culture paradigms, finding that sMOCS retain and amplify key subpopulations from the original patients’ samples and recapitulate features of the original metastasis that do not emerge from classical 2D culture, including retention of individual patients’ specificities. By enabling the enrichment of uniquely informative cell subpopulations from HGSOC metastasis and the clonal interrogation of their diversity at the functional and molecular level, this method provides a powerful instrument for precision oncology in ovarian cancer.
Independent control of mean and noise by convolution of gene expression distributions
Authors: Gerhardt Karl P. , Rao Satyajit D. , Olson Evan J. , Igoshin Oleg A. , Tabor Jeffrey J. 
Published: November 2021

AbstractGene expression noise can reduce cellular fitness or facilitate processes such as alternative metabolism, antibiotic resistance, and differentiation. Unfortunately, efforts to study the impacts of noise have been hampered by a scaling relationship between noise and expression level from individual promoters. Here, we use theory to demonstrate that mean and noise can be controlled independently by expressing two copies of a gene from separate inducible promoters in the same cell. We engineer low and high noise inducible promoters to validate this result in Escherichia coli, and develop a model that predicts the experimental distributions. Finally, we use our method to reveal that the response of a promoter to a repressor is less sensitive with higher repressor noise and explain this result using a law from probability theory. Our approach can be applied to investigate the effects of noise on diverse biological pathways or program cellular heterogeneity for synthetic biology applications.
Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release
Authors: Li Wanqiu , Wang Linlin , Wierbowski Bradley M. , Lu Mo , Dong Feitong , Liu Wenchen , Li Sisi , Wang Peiyi , Salic Adrian , Gong Xin 
Published: November 2021

AbstractThe membrane protein Dispatched (Disp), which belongs to the RND family of small molecule transporters, is essential for Hedgehog (Hh) signaling, by catalyzing the extracellular release of palmitate- and cholesterol-modified Hh ligands from producing cells. Disp function requires Furin-mediated proteolytic cleavage of its extracellular domain, but how this activates Disp remains obscure. Here, we employ cryo-electron microscopy to determine atomic structures of human Disp1 (hDisp1), before and after cleavage, and in complex with lipid-modified Sonic hedgehog (Shh) ligand. These structures, together with biochemical data, reveal that proteolytic cleavage opens the extracellular domain of hDisp1, removing steric hindrance to Shh binding. Structure-guided functional experiments demonstrate the role of hDisp1–Shh interactions in ligand release. Our results clarify the mechanisms of hDisp1 activation and Shh morphogen release, and highlight how a unique proteolytic cleavage event enabled acquisition of a protein substrate by a member of a family of small molecule transporters.
Nitrogen-incorporation activates NiFeOx catalysts for efficiently boosting oxygen evolution activity and stability of BiVO4 photoanodes
Authors: Zhang Beibei , Yu Shiqiang , Dai Ying , Huang Xiaojuan , Chou Lingjun , Lu Gongxuan , Dong Guojun , Bi Yingpu 
Published: November 2021

AbstractDeveloping low-cost and highly efficient catalysts toward the efficient oxygen evolution reaction (OER) is highly desirable for photoelectrochemical (PEC) water splitting. Herein, we demonstrated that N-incorporation could efficiently activate NiFeOx catalysts for significantly enhancing the oxygen evolution activity and stability of BiVO4 photoanodes, and the photocurrent density has been achieved up to 6.4 mA cm−2 at 1.23 V (vs. reversible hydrogen electrode (RHE), AM 1.5 G). Systematic studies indicate that the partial substitution of O sites in NiFeOx catalysts by low electronegative N atoms enriched the electron densities in both Fe and Ni sites. The electron-enriched Ni sites conversely donated electrons to V sites of BiVO4 for restraining V5+ dissolution and improving the PEC stability, while the enhanced hole-attracting ability of Fe sites significantly promotes the oxygen-evolution activity. This work provides a promising strategy for optimizing OER catalysts to construct highly efficient and stable PEC water splitting devices.