bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revival of a forgotten valve: use of the percutaneous clip for the treatment of tricuspid regurgitation
Authors: Bartorelli Antonio L , Ferrari Cristina , Olivares Paolo , Monizzi Giovanni , Grancini Luca 
Published: October 2021

Abstract
Tricuspid regurgitation (TR) is common in patients with left-sided valvular heart disease and is independently associated with increased mortality and morbidity because it leads to right-sided heart failure and recurrent hospitalization. The prognostic benefit of isolated TR surgical repair or replacement is unclear and medical treatment of decompensated right heart failure alone does not prevent the progression of the disease. Recently, minimal invasive catheter-based techniques have emerged as a feasible and effective option for TR treatment in selected high-risk patients who would clinically benefit from tricuspid valve repair. We provide an overview of the current state of transcatheter TR treatment using the edge-to-edge technique.
Aortic and mitral bioprosthetic valve dysfunction: surgical or percutaneous solutions?
Authors: Belluschi Igor , Buzzatti Nicola , Castiglioni Alessandro , De Bonis Michele , Maisano Francesco , Alfieri Ottavio 
Published: October 2021

Abstract
In the last years, there has been a trend to prefer biological prostheses, especially among young patients, with the aim to avoid anticoagulant treatment. Surgical tissue valves have so far demonstrated their solid long-term durability. However, younger age has been identified as one of the main risk factors for developing structural valve deterioration (SVD). As a consequence, the proportion of subjects at risk for valve dysfunction will constantly rise in the near future. However, while surgical reintervention has always been considered the gold standard for treatment of prosthesis deterioration, the introduction of transcatheter heart valves could offer new therapeutical options, particularly among high-risk patients, aiming a second less invasive chance. The recent standardization of valve durability definitions will soon allow a more comprehensive understanding of the mechanism underlying SVD and guide the choice of prosthesis for patients needing valve replacement.
Correlation between cardiovascular risk factors and cognitive decline
Authors: Desideri Giovambattista , Bocale Raffaella 
Published: October 2021

AbstractThe number of people suffering from dementia in the world is progressively increasing due to the expansion of the geriatric population in which this clinical condition is more frequent. The appearance of a variable degree of cognitive decline up to full-blown dementia does not, however, represent the inevitable fate of those who age, as the studies conducted in the centenarians clearly indicate. Indeed, the age-specific incidence of dementia has progressively decreased in many geographical areas, probably due to an improvement in lifestyles and health care. In fact, a growing number of scientific evidence shows how chronic exposure over the course of life, starting from young adulthood, to various risk factors—arterial hypertension, diabetes mellitus, obesity, tobacco smoke, sleep disorders—contribute significantly to the development of cognitive decline and dementia in the course of senescence. These risk factors, in fact, can trigger and amplify the various neuropathological mechanisms underlying the development of decline, progressively reducing the functional reserve of the brain. Although definitive evidence deriving from ad hoc intervention studies is not currently available, it is legitimate to assert that the early control of cardiovascular risk factors can represent today the most effective tool for the prevention of dementia.
The wireless pacemaker is on again; from electro-stimulation to synchronization
Authors: Stazi Filippo 
Published: October 2021

Abstract
Leadless stimulation of the right ventricle is now a reality, especially in patients with very specific indications and clinical characteristics, even in the absence of randomized studies to support its use. The reduction of device costs and the refinement of atrioventricular synchronization algorithms will sanction its greater diffusion in the future. The possibility of using leadless technology also for resynchronization therapy, on the other hand, is currently a promising option but, pending randomized studies with robust case histories and adequate follow-ups, it should still be considered as a niche therapy, to be limited to centres highly specialized and in patients in whom conventional resynchronization has been impossible or ineffective.
The myosin activator: is another step forward in heart failure therapy?
Authors: Abete Raffaele , Iacovoni Attilio , Senni Michele 
Published: October 2021

Abstract
Selective cardiac myosin activators constitute a new class of drugs capable of increasing cardiac contractility independently of intracellular calcium concentrations. In the GALACTIC-HF study, the first of this class of molecules, omecamtiv mercabil, was compared with the standard of care according to current guidelines, showing a significant reduction in the composite endpoint of first episode of heart failure or mortality due to cardiovascular causes in patients exposed to treatment compared with placebo. In particular, the effect was more pronounced for decreasing ejection fraction values, suggesting a potential further benefit of selective cardiac myosin activators in this category of patients.
Thrombosis in pre- and post-vaccination phase of COVID-19
Authors: Violi Francesco , Cammisotto Vittoria , Pastori Daniele , Pignatelli Pasquale 
Published: October 2021

Abstract
Acute infections may be complicated by thrombosis occurring in the venous and arterial circulation. This may be observed in patients with community-acquired pneumonia (CAP) and also in patients with coronavirus 2019 (COVID-19), that is a pandemic characterized by severe acute respiratory syndrome (SARS-CoV-2) needing mechanical ventilation and intensive care unit treatment. However, the type and rate of thrombosis can vary according to the cause of pneumonia as is more frequently complicated by arterial thrombosis in CAP, while an equal incidence of venous and arterial thrombosis occurs in SARS-CoV-2. The mechanisms of disease are overall platelet-related in CAP while activation of both platelets and clotting system is implicated in the pathogenesis of thrombosis in SARS-CoV-2; this finding could imply a different therapeutic approach of the two settings. Thrombosis may also occur in subjects vaccinated against SARS-CoV-2 even if its incidence is not so high (1/100 000); this rare effect occurs more prevalently in young women, is independent from known risk factors of thrombosis, is caused by antibodies against platelet PF4 and is counteracted by treatment with immunoglobulin and glucocorticoids.
A multi-intervention protocol to improve sleep quality in a coronary care unit
Authors: Beltrami Flávia Gabe , John Ângela Beatriz , de Macedo Bruno Rocha , Corrêa Júnior Vicente , Nguyen Xuân Lan , Pichereau Claire , Maury Eric , Fleury Bernard , Gus Miguel , Fagondes Simone Chaves 
Published: October 2021

Abstract

Aims
Poor sleep is a frequent occurrence in the critical illness. Evaluate sleep quality and test the effect of a multi-intervention sleep care protocol in improving sleep quality in a coronary care unit (CCU).

Methods and results
Quasi-experimental study, carried out in two phases. During the first phase, the control group (n = 58 patients) received usual care. Baseline sleep data were collected through the Richards-Campbell Sleep Questionnaire (RCSQ) and the Sleep in the Intensive Care Unit Questionnaire (SICUQ). During the second phase (n = 55 patients), a sleep care protocol was implemented. Interventions included actions to promote analgesia, reduce noise, brightness, and other general measures. Sleep data were collected again to assess the impact of these interventions. The intervention group had better scores in overall sleep depth [median (interquartile range)] [81 (65–96.7) vs. 69.7 (50–90); P = 0.046]; sleep fragmentation [90 (65–100) vs. 69 (42.2–92.7); P = 0.011]; return to sleep [90 (69.7–100) vs. 71.2 (40.7–96.5); P = 0.007]; sleep quality [85 (65–100) vs. 71.1 (49–98.1); P = 0.026]; and mean RCSQ score [83 (66–94) vs. 66.5 (45.7–87.2); P = 0.002] than the baseline group. The main barriers to sleep were pain [1 (1.0–5.5)], light [1 (1.0–5.0)], and noise [1 (1.0–5.0)]. The most rated sources of sleep-disturbing noise were heart monitor alarm [3 (1.0–5.25)], intravenous pump alarm [1.5 (1.0–5.00)]. and mechanical ventilator alarm [1 (1.0–5.0)]. All were significantly lower in the intervention group than in the baseline group.

Conclusion
A multi-intervention protocol was feasible and effective in improving different sleep quality parameters and reducing some barriers to sleep in CCU patients.
Irreversibility analysis of induced swirl flow inside the pipes of flat-plate solar collector using dual tangential nozzles
Authors: Cao Yan , Ayed Hamdi , Issakhov Alibek , Sene Ndolane , Bouallegue Belgacem 
Published: October 2021

Abstract
In the present research, dual-nozzle swirl generator was installed at the blocked end of the straight tube to inject flow tangential to the wall of the pipe with various injection inclinations compared to the longitudinal axis. This causes a swirl flow inside the pipe. Altering some decisive variables, including injection angle, side of nozzle cross-section, pipe diameter, and flow rate, caused to attain various cases with unique hydraulic-geometrical characteristics. Classes ‘A…-D50-N…-M…’ and ‘A…-D20-N…-M…’ bear the main characteristics of the cases embodied in their sub-classes. Entropy generation (St), Nu*, NE, Heat Transfer Improvement (HTI) index and ${\eta}_{w-s}$ were used as effective tools for the basement of the system based on the irreversibility concept. The results showed that all of the cases of class ‘A…-D50-N…-M…’ cause lower frictional-contributed and higher thermal-contributed entropy generation compared to the class ‘A…-D20-N…-M…’. The highest values of the HTI index are 1.5 and 1.763 obtained by ‘A30-D20-N5-M0.4’ and ‘A90-D20-N6.25-M0.1’, respectively.
Work status and work ability of patients receiving kidney replacement therapy: results from a European survey
Authors: de Jong Rianne W , Boezeman Edwin J , Chesnaye Nicholas C , Bemelman Frederike J , Massy Ziad A , Jager Kitty J , Stel Vianda S , de Boer Angela G E M 
Published: October 2021

ABSTRACT

Background
Employment is important for the quality of life and financial security of patients of working age receiving kidney replacement therapy (KRT). We aimed to examine self-reported work status and general, physical and mental work ability and to determine associations between demographic, disease-related, work-related and macroeconomic factors and employment.

Methods
Europeans from 37 countries, ages 19–65 years, treated with dialysis or kidney transplantation, filled out the web-based or paper-based cross-sectional EDITH kidney patient survey between November 2017 and January 2019. We performed descriptive analyses and multivariable generalized logistic mixed models.

Results
Of the 3544 patients, 36.5% were employed and working [25.8% of dialysis patients, 53.9% of kidney transplant recipients (KTRs)]. The mean general work ability was 5.5 out of 10 (dialysis: 4.8, KTRs: 6.5). Non-working patients (all: 4.1, dialysis: 3.9, KTRs: 4.7) scored lower than working patients (all: 7.7, dialysis 7.3, KTRs: 8.0). Working dialysis patients scored lower on physical and mental work ability (7.1 and 8.1) than working KTRs (8.0 and 8.4; P &lt; 0.001). Impaired physical work ability (42.7%) was more prevalent than impaired mental work ability (26.7%). Male sex, age 40–49 years, higher education, home dialysis or kidney transplantation as current treatment, treatment history including kidney transplantation, absence of diabetes mellitus, better general work ability and higher country gross domestic product were positively associated with employment (P &lt; 0.05).

Conclusions
Low employment rates and impaired work ability were prevalent among European patients receiving KRT. Demographic, disease-related, work-related and macro-economic factors were associated with employment.
Hybrid Robotics for Endoscopic Transnasal Skull Base Surgery: Single-Centre Case Series
Authors: Zappa Francesca , Madoglio Alba , Ferrari Marco , Mattavelli Davide , Schreiber Alberto , Taboni Stefano , Ferrari Erika , Rampinelli Vittorio , Belotti Francesco , Piazza Cesare , Fontanella Marco Maria , Nicolai Piero , Doglietto Francesco 
Published: October 2021

Abstract

BACKGROUND
Only preclinical studies and case reports have described robotic surgery for endoscopic transnasal skull base surgery.

OBJECTIVE
To evaluate the role of a novel robotic endoscope holder, developed for transsphenoidal surgery.

METHODS
Patients were prospectively enrolled for 3 mo at the Neurosurgery Unit of Brescia. Endoscope Robot® was used to assist during the sphenoidal phase of the approach, tumor removal, and skull base reconstruction. A Likert scale questionnaire was given to all surgeons after each procedure. Patients who underwent robotic-assisted surgery were matched with nonrobotic ones for pathology and type of procedure. All surgical videos were evaluated during bimanual phases.

RESULTS
Twenty-one patients underwent robot-assisted, endoscopic transsphenoidal surgery for different pathologies (16 pituitary adenomas, 3 chordomas, 1 craniopharyngioma, 1 pituitary exploration for Cushing disease) for a total of 23 procedures (1 patient underwent 2 endoscopic revisions of a skull base reconstruction). Subjective advantages reported by surgeons included smoothness of movement, image steadiness, and improvement of maneuvers in narrow spaces and with angled endoscopes; as the main limitation, Endoscope Robot® appeared to be relatively heavy during the initial endoscope positioning. A comparative analysis with a historical matched cohort documented similar clinical outcomes, while endoscope lens cleaning and position readjustments were significantly less frequent in robotic procedures.

CONCLUSION
Although confirmation in larger studies is needed, Endoscope Robot® was a safe and effective tool, especially advantageous in lengthy interventions through deep and narrow corridors.
Symptomatic Epidural Hematoma After Elective Cervical Spine Surgery: Incidence, Timing, Risk Factors, and Associated Complications
Authors: Abola Matthew V , Du Jerry Y , Lin Charles C , Schreiber-Stainthorp William , Passias Peter G 
Published: October 2021

Abstract

BACKGROUND
As the rate of elective cervical spine surgery increases, studies of complications may improve quality of care. Symptomatic postoperative cervical epidural hematomas (PCEH) are rare but result in significant morbidity. Because of their low incidence, the risk factors and complications associated with symptomatic PCEH remain unclear.

OBJECTIVE
To clarify the prevalence, timing, variables, and complications associated with PCEH following elective cervical spine surgery.

METHODS
Using the American College of Surgeons National Surgical Quality Improvement Program database, cervical spine surgeries performed between 2012 and 2016 were identified using Current Procedural Terminology codes. Symptomatic PCEH was defined as readmission or reoperation events specifically associated with International Classification of Diseases code diagnoses of postoperative hematoma within 30 d of index surgery. Multivariate models were created to assess the independent association of symptomatic PCEH with other postoperative complications.

RESULTS
There were 53233 patients included for analysis. The overall incidence of symptomatic PCEH was 0.4% (n = 198). Reoperation occurred in 158 cases (78.8%), of which 2 required a second reoperation (1.3%). The majority (91.8%) of hematomas occurred within 15 d of surgery. Multivariate analysis identified male gender, American Society of Anesthesiologists classes 3 to 5, bleeding disorder, increasing number of operative levels, revision surgery, dural repair, and perioperative transfusion as independent factors associated with PCEH. Upon controlling for those confounders, PCEH was independently associated with cardiac arrest, stroke, deep vein thrombosis, surgical site infection, and pneumonia.

CONCLUSION
Postoperative epidural hematomas requiring readmission or reoperation following elective cervical spine surgery occurred at an incidence of 0.4%. Symptomatic PCEHs are associated with increased rates of numerous major morbidities.
Coupling Stokes Flow with Inhomogeneous Poroelasticity
Authors: Taffetani Matteo , Ruiz-Baier Ricardo , Waters Sarah 
Published: October 2021

Summary
We investigate the behaviour of flux-driven flow through a single-phase fluid domain coupled to a biphasic poroelastic domain. The fluid domain consists of an incompressible Newtonian viscous fluid while the poroelastic domain consists of a linearly elastic solid filled with the same viscous fluid. The material properties of the poroelastic domain, that is permeability and elastic parameters, depend on the inhomogeneous initial porosity field. We identify the dimensionless parameters governing the behaviour of the coupled problem: the ratio between the magnitudes of the driving velocity and the Darcy flows in the poroelastic domain, and the ratio between the viscous pressure scale and the size of the elastic stresses in the poroelastic domain. We consider a perfusion system, where flow is forced to pass from the single-phase fluid to the biphasic poroelastic domain. We focus on a simplified two-dimensional geometry with small aspect ratio and perform an asymptotic analysis to derive analytical solutions. The slender geometry is divided in four regions, two outer domains that describe the regions away from the interface and two inner domains that are the regions across the interface. Our analysis advances the quantitative understanding of the role of heterogeneous material properties of a poroelastic domain on its mechanical response when coupled with a fluid domain. The analysis reveals that, in the interfacial zone, the fluid and the elastic behaviours of this coupled Stokes—poroelastic problem can be treated separately via (i) a Stokes–Darcy coupling and (ii) the solid skeleton being stress free. This latter finding is crucial to derive the coupling condition across the outer domains for both the elastic part of the poroelastic domain and the fluid flow. Via specification of heterogeneous material properties distribution, we reveal the effects of heterogeneity and deformability on the mechanics of the poroelastic domain.
Phylogenetics and Evolution of Potato Virus V: Another Potyvirus that Originated in the Andes
Authors: Fuentes Segundo , Gibbs Adrian J. , Adams Ian P. , Hajizadeh Mohammad , Kreuze Jan , Fox Adrian , Blouin Arnaud G. , Jones Roger A. C. 
Published: October 2021

Potato virus V (PVV) causes a disease of potato (Solanum tubersosum) in South and Central America, Europe, and the Middle East. We report here the complete genomic sequences of 42 new PVV isolates from the potato’s Andean domestication center in Peru and of eight historical or recent isolates from Europe. When the principal open reading frames of these genomic sequences together with those of nine previously published genomic sequences were analyzed, only two from Peru and one from Iran were found to be recombinant. The phylogeny of the 56 nonrecombinant open reading frame sequences showed that the PVV population had two major phylogroups, one of which formed three minor phylogroups (A1 to A3) of isolates, all of which are found only in the Andean region of South America (Peru and Colombia), and the other formed two minor phylogroups, a basal one of Andean isolates (A4) that is paraphyletic to a crown cluster containing all the isolates found outside South America (World). This suggests that PVV originated in the Andean region, with only one minor phylogroup spreading elsewhere in the world. In minor phylogroups A1 and A3, there were two subclades on long branches containing isolates from S. phureja evolving more rapidly than the others, and these interfered with dating calculations. Although no temporal signal was directly detected among the dated nonrecombinant sequences, PVV and potato virus Y (PVY) are from the same potyvirus lineage and are ecologically similar, so “subtree dating” was done via a single maximum likelihood phylogeny of PVV and PVY sequences, and PVY’s well-supported 157 ce “time to most common recent ancestor” was extrapolated to date that of PVV as 29 bce. Thus the independent historical coincidences supporting the datings of the PVV and PVY phylogenies are the same; PVV arose ≥2,000 years ago in the Andes and was taken to Europe during the Columbian Exchange, where it diversified around 1853 ce, soon after the European potato late blight pandemic. PVV is likely to be more widespread than currently realized and is of biosecurity relevance for world regions that have not yet recorded its presence.[Formula: see text] Copyright © 2022 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Genomic Sequence Data of Bacterial Isolates from Pistachio Trees and Other Woody Plants in California Are Inconsistent with the Role of Rhodococcus as the Causative Agent of Pistachio Bushy Top Syndrome
Authors: Riely Brendan K. , Nouri Mohamed T. , Riaz Kashif , Tufail Muhammad Rizwan , Gai Yunpeng , Carrasquilla Noelia , Fayyaz Amna , Chang Peter L. , Leveau Johan H. J. , Cook Douglas R. , Trouillas Florent P. 
Published: October 2021

Pistachio bushy top syndrome (PBTS) is a serious problem for pistachio growers in the western United States, but the cause of this disorder remains controversial. Recently, it was proposed that the Rhodococcus species R. fascians and R. corynebacterioides caused PBTS outbreaks in 2011 and 2015. To investigate the association of Rhodococcus spp. with PBTS in California's pistachio-growing region, Rhodococcus-like isolates were collected from diverse hosts and environments, including pistachio nurseries and orchards. Whole genome sequence analysis of 231 isolates revealed their evolutionary relationships and identified six Rhodococcus species. Combined with data on geography and host of origin, the data reveal that Rhodococcus generally, and R. fascians specifically, is ubiquitous in nature, frequently occurring in both symptomatic and asymptomatic pistachio trees and on other woody and native species. Core gene and single nucleotide polymorphism-based phylogenies and pangenome analyses differentiate R. fascians into distinct genotypes. Although we found examples of common genotypes shared between nurseries and orchards, the observed patterns are most consistent with an environmental source of strains and do not support a scenario in which individual nurseries are point sources of Rhodococcus. Moreover, none of the collected strains harbored known virulence genes, calling into question the role of these common environmental bacteria in causing PBTS. [Formula: see text] Copyright © 2022 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
COVID-19 and opioid use disorder
Authors: Mumba Mercy Ngosa , Jaiswal Jessica , Langner-Smith Natalia , Mugoya George T. , Brown Whitnee , Davis Lori L. 
Published: October 2021

Abstract:
Substance use treatment inequities among rural populations are well documented and the COVID-19 pandemic has exacerbated these inequalities, forcing healthcare providers to be creative in the delivery of treatment. Systematic reviews on the use of telehealth to treat patients with substance use disorder indicate that it is a promising alternative to in-person services. This article examines the evidence supporting the use of telehealth in treating patients with opioid use disorder and explores other promising options that can help overcome pandemic-related barriers to treatment.