bluuebunny/crossref_metadata_2025_split huggingface dataset:
A survey on single server private information retrieval in a coding theory perspective
Authors: Alfarano Gianira N. , Khathuria Karan , Weger Violetta 
Published: April 2021

AbstractIn this paper, we present a new perspective of single server private information retrieval (PIR) schemes by using the notion of linear error-correcting codes. Many of the known single server schemes are based on taking linear combinations between database elements and the query elements. Using the theory of linear codes, we develop a generic framework that formalizes all such PIR schemes. This generic framework provides an appropriate setup to analyze the security of such PIR schemes. In fact, we describe some known PIR schemes with respect to this code-based framework, and present the weaknesses of the broken PIR schemes in a unified point of view.
Cardiovascular risk profiles and 20-year mortality in older people: gender differences in the Pro.V.A. study
Authors: Trevisan Caterina , Capodaglio Giulia , Ferroni Eliana , Fedeli Ugo , Noale Marianna , Baggio Giovannella , Manzato Enzo , Maggi Stefania , Corti Maria Chiara , Sergi Giuseppe 
Published: April 2021

AbstractThe age- and gender-related cardio-metabolic changes may limit the applicability of guidelines for the prevention of cardiovascular diseases (CVD) in older people. We investigated the association of cardiovascular risk profile with 20-year all-cause and CVD-mortality in older adults, focusing on age- and gender-specific differences. This prospective study involved 2895 community-dwelling individuals aged ≥65 years who participated in the Pro.V.A study. The sum of achieved target levels (smoking, diet, physical activity, body weight, blood pressure, lipids, and diabetes) recommended by the European Society of Cardiology 2016 guidelines was assessed in each participant. From this sum, cardiovascular risk profile was categorised as very high (0–2), high (3), medium (4), low (5), and very low (6–7 target levels achieved). All-cause and CV mortality data over 20 years were obtained from health registers. At Cox regression, lower cardiovascular risk profile was associated with reduced 20-year all-cause mortality in both genders, with stronger results for women (HR = 0.42 [95%CI:0.25–0.69] and HR = 0.61 [95%CI:0.42–0.89] for very low vs. very high cardiovascular risk profile in women and men, respectively). This trend was more marked for CVD mortality. Lower cardiovascular risk profile was associated with reduced all-cause and CVD mortality only in men < 75 years, while the associations persisted in the oldest old women. A lower cardiovascular risk profile, as defined by current guidelines, may reduce all-cause and CVD mortality in older people, with stronger and longer benefits in women. These findings suggest that personalised and life-course approaches considering gender and age differences may improve the delivery of preventive actions in older people.
Typical field lines of Beltrami flows and boundary field line behaviour of Beltrami flows on simply connected, compact, smooth manifolds with boundary
Authors: Gerner Wadim 
Published: April 2021

AbstractWe characterise the boundary field line behaviour of Beltrami flows on compact, connected manifolds with vanishing first de Rham cohomology group. Namely we show that except for an at most nowhere dense subset of the boundary, on which the Beltrami field may vanish, all other field lines at the boundary are smoothly embedded 1-manifolds diffeomorphic to$${\mathbb {R}}$$R, which approach the zero set as time goes to$$\pm \, \infty$$±∞. We then drop the assumptions of compactness and vanishing de Rham cohomology and prove that for almost every point on the given manifold, the field line passing through the point is either a non-constant, periodic orbit or a non-periodic orbit which comes arbitrarily close to the starting point as time goes to$$\pm \infty$$±∞. During the course of the proof, we in particular show that the set of points at which a Beltrami field vanishes in the interior of the manifold is countably 1-rectifiable in the sense of Federer and hence in particular has a Hausdorff dimension of at most 1. As a consequence, we conclude that for every eigenfield of the curl operator, corresponding to a non-zero eigenvalue, there always exists exactly one nodal domain.
Vascular endothelial cell specification in health and disease
Authors: Marziano Corina , Genet Gael , Hirschi Karen K. 
Published: April 2021

AbstractThere are two vascular networks in mammals that coordinately function as the main supply and drainage systems of the body. The blood vasculature carries oxygen, nutrients, circulating cells, and soluble factors to and from every tissue. The lymphatic vasculature maintains interstitial fluid homeostasis, transports hematopoietic cells for immune surveillance, and absorbs fat from the gastrointestinal tract. These vascular systems consist of highly organized networks of specialized vessels including arteries, veins, capillaries, and lymphatic vessels that exhibit different structures and cellular composition enabling distinct functions. All vessels are composed of an inner layer of endothelial cells that are in direct contact with the circulating fluid; therefore, they are the first responders to circulating factors. However, endothelial cells are not homogenous; rather, they are a heterogenous population of specialized cells perfectly designed for the physiological demands of the vessel they constitute. This review provides an overview of the current knowledge of the specification of arterial, venous, capillary, and lymphatic endothelial cell identities during vascular development. We also discuss how the dysregulation of these processes can lead to vascular malformations, and therapeutic approaches that have been developed for their treatment.
Disparity between ecological and political timeframes for species conservation targets
Authors: Piipponen-Doyle Stella , Bolam Friederike C. , Mair Louise 
Published: April 2021

AbstractThe Convention on Biological Diversity’s (CBD) Aichi Target 12 aimed to prevent species extinctions and improve the conservation status of known threatened species by 2020 but has not been met. As the post-2020 global biodiversity framework is negotiated, it is essential that we learn lessons from past failures. Here, we investigate whether a reduction in extinction risk could realistically be achieved within the ten-year timeframe of the Aichi Targets. We identified threatened bird and mammal species for which a population increase could lead to down-listing on the IUCN Red List and created population models that assumed exponential population growth to predict how long it would take to reach the population size threshold required for down-listing. We found that in the best-case scenario, 39/42 birds (93%) and 12/15 mammals (80%) could be expected to show the population increase required to achieve down-listing by one Red List category within a ten-year timeframe. In contrast, under the worst-case scenario, 67% birds and 40% mammals were predicted to take > 10 years to reach the population threshold. These results indicate a disparity between the ecological timeframes required for species to show a reduction in extinction risk, and the political timeframes over which such ecological change is expected to be achieved and detected. We suggest that quantitative analyses should be used to set realistic milestone targets in the post-2020 framework, and that global indicators should be supplemented with temporally sensitive measures of conservation progress in order to maintain political and societal motivation for species conservation.
Game-theoretical model for the sustainable use of thermal water resources: the case of Ischia volcanic Island (Italy)
Authors: Kicsiny Richárd , Piscopo Vincenzo , Scarelli Antonino , Varga Zoltán 
Published: April 2021

AbstractThe Island of Ischia, one of the Italian active volcanoes, is a famous tourist resort for spa treatments. Spas are supplied by withdrawals from groundwaters which are characterized by a wide range of chemical compositions, salinity and temperature. In natural conditions, the hydrogeological system is recharged by rainfall and by deep fluids; the discharge is towards the sea and the springs. During the peak of the tourist season, when approximately 240 wells are operating simultaneously, a significant additional recharge of the aquifers derives from seawater and from upwelling increase in deep fluids. Although this does not compromise the availability of groundwater, the pumping often determines variation in composition and temperature of groundwater over time. Conversely, the maintenance of a stable quality of thermal waters represents one of the requirements for their therapeutic use in the spas. The study aims to establish game-theoretical modeling of the optimal sustainable exploitation of the groundwater resources of the island by competing users (spas) falling in the same flow tube of the aquifer. In the game the spas are the players, the strategy of a player consists of a fixed pumping rate and daily time durations of pumping, and the player’s utility or payoff is proportional to the total quantity of withdrawn thermal water in a given time period. A special constrained Pareto optimal strategy choice is obtained, considered as a cooperative solution of the game. Pareto optimality means that there is no other strategy choice that makes one player better off without making some other player worse off.
Data workflow to incorporate thermodynamic energies from Calphad databases into grand-potential-based phase-field models
Authors: Dargahi Noubary Kaveh , Kellner Michael , Hötzer Johannes , Seiz Marco , Seifert Hans J. , Nestler Britta 
Published: April 2021

Abstract
In order to approximate Gibbs energy functions, a semi-automated framework is introduced for binary and ternary material systems, using Calphad databases. To generate Gibbs energy formulations by means of second-order polynomials, the framework includes a precise approach. Furthermore, an optional extensional step enables the modeling of systems in which a direct generation leads to the unsatisfactory results in the representation of the thermodynamics. Furthermore, an optional extensional step enables the modeling of systems, in which a direct generation leads to the unsatisfactory results, when representing the thermodynamics. Within this extension, the commonly generated functions are modified to satisfy the equilibrium conditions in the observed material systems, leading to a better correlation with thermodynamic databases. The generated Gibbs energy formulations are verified by recalculating the equilibrium concentrations of the phases and rebuilding the phase diagrams in the considered concentration and temperature ranges, prior to the simulation studies. For all comparisons, a close match is achieved between the results and the Calphad databases. As practical examples of the method, phase-field simulation studies for the directional solidification of the binary – and the ternary – eutectic systems are performed. Good agreements between the simulation results and the reported theoretical and experimental studies from literature are found, which indicates the applicability of the presented approaches.

Graphical Abstract
The Innate Immune Response Characterizes Posterior Reversible Encephalopathy Syndrome
Authors: Nelke Christopher , Schulte-Mecklenbeck Andreas , Pawlitzki Marc , Rolfes Leoni , Räuber Saskia , Gross Catharina C. , Minnerup Jens , Meuth Sven G. , Wiendl Heinz , Ruck Tobias 
Published: April 2021

AbstractWhile posterior reversible encephalopathy syndrome (PRES) is often characterized by an inflammatory cerebrospinal-fluid (CSF) profile, knowledge of immune cell patterns in PRES is lacking. Thus, we retrospectively characterized CSF and peripheral blood (PB) from 15 PRES patients, which we analyzed by multidimensional flow cytometry (FC). Results were compared to 72 controls, as well as to 9 patients with progressive multifocal leukoencephalopathy (PML, as a relevant differential diagnosis) and 15 multiple sclerosis patients (MS, as a classical neuroinflammatory disorder), respectively. Total protein level in CSF from PRES patients was elevated compared to that in controls, but not to MS and PML. In-depth FC analysis revealed no differences for adaptive immune cells (B cells, plasma cells, CD4+, and CD8+ T cells) in PB or CSF of PRES compared to controls. In contrast, we observed alterations of the adaptive immune response in CSF of PML and MS compared to PRES, indicating that the adaptive immune response is not a driver of disease in PRES. Indeed, PRES was characterized by an innate immune response with CD14++/CD16+ (intermediate) monocytes elevated in PB and CSF, while CD14++/CD16− (classical) monocytes were decreased in PB from PRES patients as compared to controls. Levels of CD14++/CD16+ monocytes correlated with the duration of hospital stay as a surrogate marker for disease severity in PRES patients. Our findings argue for a role of innate rather than adaptive immunity in the pathophysiology of PRES. The observed shift in monocyte subsets might provide valuable diagnostic clues for the clinical management of these patients.
Porosity Dynamics through Carbonate-Reaction Kinetics in High-Temperature Aquifer Storage Applications
Authors: Tilley B. S. , Ueckert M. , Baumann T. 
Published: April 2021

AbstractWhile near-surface geothermal energy applications for the heating and cooling of buildings have been in use for decades, their practical adoption is limited by the energy transport rates through soils. Aquifers provide a means to use convective heat transport to improve heat transfer between the building and the aquifer. However, the solid matrix in the aquifer is carbonaceous in nature, and calcification prevention techniques in the heat exchangers for the building also lead to dissolution of the aquifer matrix. Due to the Arrhenius nature of the reaction, dissolution rates may decrease with increasing temperature. An effective medium model is derived for the energy, calcium species, and fluid transport through a dynamic calcite porous medium which undergoes a reaction between the matrix and fluid. To better discern how these competing phenomena affect thermal transport in the aquifer, a two-dimensional Cartesian system is considered, where the vertical axis is parallel to the borehole axis, and flow is in the horizontal direction. An effective medium model is derived for the energy, calcium species, and fluid transport through a dynamic calcite porous medium which undergoes a reaction between the matrix and fluid. Since the fluid velocity decays algebraically with radial distance from the borehole axis, two flow regimes are considered. In one regime, far from the borehole where flow rates are small, conductive thermal transport acts faster than the species transport, leading to a case where precipitation dominates and regions of the smallest porosity contract to limit energy recovery. In regions with larger porosity, moderate advection of the species is sufficient to prevent significant pore closures over the time scale of exploration. The second regime, closer to the borehole, larger flow rates reduce species concentrations sufficiently to dissolve the solid phase between pores. In this second regime, Taylor dispersion effects in both energy and species transport compete, but thermal conduction acts more slowly than advection, promoting dissolution. The critical limitation in modeling the long-term evolution of the aquifer structure is the in situ dissolution rate.
A image encryption algorithm based on chaotic Lorenz system and novel primitive polynomial S-boxes
Authors: Al-Maadeed Temadher Alassiry , Hussain Iqtadar , Anees Amir , Mustafa Muhammad Tahir 
Published: April 2021

AbstractWe have proposed a robust, secure and efficient image encryption algorithm based on chaotic maps and algebraic structure. Nowadays, the chaotic cryptosystems gained more attention due to their efficiency, the assurance of robustness and high sensitivity corresponding to initial conditions. In literature, there are many encryption algorithms that can simply guarantees security while the schemes based on chaotic systems only promises the uncertainty, both of them can not encounter the needs of current scenario. To tackle this issue, this article proposed an image encryption algorithm based on Lorenz chaotic system and primitive irreducible polynomial substitution box. First, we have proposed 16 different S-boxes based on projective general linear group and 16 primitive irreducible polynomials of Galois field of order 256, and then utilized these S-boxes with combination of chaotic map in image encryption scheme. Three chaotic sequences can be produced by the disturbed of Lorenz chaotic system corresponding to variables x, y and z. We have constructed a new pseudo random chaotic sequence ki based on x, y and z. The plain image is encrypted by the use of chaotic sequence ki and XOR operation to get a ciphered image. To show the strength of presented image encryption, some renowned analyses are performed.
A psychometric evaluation of the Functional assessment of cancer therapy—kidney symptom index (FKSI-19) among renal cell carcinoma patients suggesting an alternative two-factor structure
Authors: Rosenblad Andreas Karlsson , Sundqvist Pernilla , Westman Bodil , Ljungberg Börje 
Published: April 2021

Abstract
Purpose
To psychometrically evaluate the hypothesized four-factor structure of the 19-item Functional Assessment of Cancer Therapy—Kidney Symptom Index (FKSI-19) health-related quality of life (HRQoL) instrument in a sample of surgically treated renal cell carcinoma (RCC) patients and examine if an alternative factor structure with good psychometric properties may be derived from the available items.

Methods
The model fit of the hypothesized four-factor structure was examined using confirmatory factor analysis on cohort data from 1731 individuals included in the National Swedish Kidney Cancer Register who had undergone surgery for RCC during the three years 2016–2018 and answered the FKSI-19 instrument within 6–12 months after surgery. Exploratory factor analysis was applied to the same dataset to derive a possible alternative factor solution.

Results
The four-factor structure did not reach the thresholds for good model fit using the normed χ2-value or the Comparative Fit Index, although the Standardized Root Mean Square Residual and Root Mean Square Error of Approximation measures indicated good and acceptable model fits, respectively. An alternative 14-item trimmed FKSI version (FKSI-14) with a two-factor structure derived from the available FKSI-19 items was found to measure the same aspects of HRQoL as the full FKSI-19 instrument.

Conclusion
The present study is the first to use psychometric methods for examining the factor structure of the FKSI-19 instrument. The hypothesized four-factor structure of FKSI-19 provided a barely acceptable model fit. The two-factor FKSI-14 structure may be used as an alternative or complement to the four-factor structure when interpreting the FKSI-19 instrument.
Efficiency comparison of B6(Cg)-Tyrc−2j /J and C57BL/6NTac embryos as hosts for the generation of knockout mice
Authors: Ma Yu’e , He Lei , Xiang Lijie , Zhang Jie , Wang Jing , Zhu Wenjing , Cao Wenni , Zhu Yichen , Gao Man , Zhou Fei , Liu Zhiwei 
Published: April 2021

AbstractCareful selection of the host embryo is critical to the efficient production of knockout (KO) mice when injecting mouse embryonic stem (mES) cells into blastocysts. B6(Cg)-Tyrc−2j/J (B6 albino) and C57BL/6NTac (B6NTac) strains of mice are widely used to produce host blastocysts for such procedures. Here, we tested these two strains to identify an appropriate match for modified agouti C57BL/6N (JM8A3.N1) mES cells. When comparing blastocyst yield, super-ovulated B6NTac mice produced more injectable blastocysts per female than B6 albino mice (8.2 vs. 5.4). There was no significant difference in birth rate when injected embryos were transferred to the same pseudopregnant recipient strain. However, the live birth rate was significantly higher for B6NTac blastocysts than B6 albino blastocysts (62.7% vs. 50.2%). In addition, the proportion of pups exhibiting high-level and complete chimerism, as identified by coat color, was also significantly higher in the B6NTac strain. There was no obvious difference in the efficiency of germline transmission (GLT) when compared between B6NTac and B6 albino host embryos (61.5% vs. 63.3% for mES clones; 64.5% vs. 67.9% for genes, respectively), thus suggesting that an equivalent GLT rate could be obtained with only a few blastocyst injections for B6NTac embryos. In conclusion, our data indicate that B6NTac blastocysts are a better choice for the microinjection of JM8A3.N1 mES cells than B6 albino blastocysts.
Plant age affects intraspecific variation in functional traits
Authors: Henn Jonathan J. , Damschen Ellen I. 
Published: April 2021

AbstractFunctional traits are often used to examine ecological patterns and processes. Ontogeny—changes that occur over time as the result of development—generates variation in traits within individual organisms. We aimed to quantify the role of ontogeny in structuring functional trait variation across a range of co-existing herbaceous perennial species and hypothesized that ontogenetic variation in traits would be greater in younger vs. older plants. We grew eight herbaceous perennial forb species common in tallgrass prairies from seed in a greenhouse in Madison, Wisconsin, USA to determine how and when time-related variation in functional traits is large relative to other sources of variation, such as differences between leaves and species. We destructively measured common functional traits on four individuals of each species every two weeks for 19 weeks, including leaf mass fraction, root mass fraction, stem mass fraction, specific leaf area, leaf dry matter content, and leaf area. We found that most functional traits indeed change through time, that the direction of many changes are consistent between species but the magnitude of change is species specific, and most time-related variation occurred earlier in development. These results emphasize the importance of considering sampling timing and differences between young and old plants when measuring functional traits. Our results suggest that ontogenetic intraspecific variation can be substantial, especially early in life. It may be problematic to use traits measured from mature plants to interpret the importance of processes that occur at earlier life stages or vice versa; using seedling traits to understand adult plant responses may also be inappropriate.
A Fast Transform for Brain Connectivity Difference Evaluation
Authors: Zanin Massimiliano , Ivanoska Ilinka , Güntekin Bahar , Yener Görsev , Loncar-Turukalo Tatjana , Jakovljevic Niksa , Sveljo Olivera , Papo David 
Published: April 2021

AbstractAnatomical and dynamical connectivity are essential to healthy brain function. However, quantifying variations in connectivity across conditions or between patient populations and appraising their functional significance are highly non-trivial tasks. Here we show that link ranking differences induce specific geometries in a convenient auxiliary space that are often easily recognisable at mere eye inspection. Link ranking can also provide fast and reliable criteria for network reconstruction parameters for which no theoretical guideline has been proposed.