bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parameter Genetik Karakter Agronomi pada Galur F1 Padi Hasil Persilangan Galur Murni dan Kultivar Lokal Indonesia
Authors: Adi Eko Binnaryo Mei , Indrayani Sri , Burhana Nana , Mulyaningsih Enung Sri 
Published: May 2021

Padi merupakan salah satu sumber karbohidrat utama bagi masyarakat Indonesia. Upaya pengembangan varietas baru sangat bergantung pada ketersediaan plasma nutfah sebagai sumber material genetik. Salah satu cara dalam pengembangan varietas baru melalui persilangan buatan untuk menciptakan keragaman dengan menggunakan kultivar lokal dan varietas/galur unggul. Tujuan penelitian ialah untuk mengeksplorasi korelasi, heterosis, aksi gen, dan heritabilitas arti luas pada delapan karakter padi, yang dapat digunakan dalam melakukan seleksi. Kegiatan persilangan buatan telah dilakukan dengan menggunakan satu galur unggul dan empat kultivar padi lokal yang memiliki karakter beragam. Empat populasi hasil persilangan (F1) ditanam menggunakan rancangan acak lengkap dengan empat ulangan, serta lima tetua (galur unggul dan padi lokal) sebagai pembanding. Hasil perhitungan korelasi menemukan bahwa terdapat satu variabel yang menunjukan korelasi pada hampir semua karakter yaitu bobot malai. Heritabilitas tinggi terdapat pada karakter umur panen, panjang malai, jumlah gabah permalai, bobot 1000 biji dan tinggi tanaman. Persilangan yang menunjukan fenomena heterosis negatif ialah pada B14081H-296 x Salak dan Dampak x Carogol sehingga memiliki umur panen yang lebih pendek dari rata-rata kedua tetua dengan aksi gen dominan sebagian dan aditif.
Parenting Style and Adolescent Adjustment: Findings of a Cross-Sectional Study in Urban Dhaka
Authors: Bhuiyan Armina , Islam Md Ziaul , Riaz Baizid Khoorshid , Md Hamdullah - 
Published: May 2021

Background: Adolescent adjustment is associated by parenting style as well as influenced by other factors of life. The objective of this study was to assess the association between parenting style and adolescent adjustment.
Methods: This cross-sectional study was conducted among 360 adolescents (180 boys and 180 girls) between 15-19 years selected by systematic random sampling from two institutions. Data were collected by semi-structured selfadministered questionnaire after taking informed written consent. The research was conducted in full accord with ethical principles and by keeping in view of the objectives of the study.
Results: Among the students, majority (74.2%) were between 15-17 years. The mean (±SD) of age was 16.66 (±1.108). Regarding parenting style, majority, 40.0% parents followed permissive style, 25.8% and 25.3% followed authoritative parenting. Only 8.9%followed negligent parenting. Majority, 59.7% of the adolescent were well adjusted. Parenting style was associated with adolescent adjustment (p<.01). There was significant mean difference in adjustment between boys and girls showing better adjustment of boys than girls (p<.01). Logistic regression between parenting style and adolescent adjustment showed, adjustment was high (OR=6.3) in permissive parenting.
Conclusion: This study showed there is significant influence of parenting style in adjustment of adolescent boys and girls which is related to the adjustment in almost all areas of life.
JOPSOM 2020; 39(2): 8-13
ANALISA PERILAKU KONSUMEN : STRATEGI MEMENANGKAN PERSAINGAN BISNIS DI ERA EKONOMI DIGITAL
Authors: Santoso Rachmad , Munawi Hisbulloh Ahlis , Nevita Ary Permatadeny 
Published: May 2021

Perkembangan teknologi informasi dan telekomunikasi yang terjadi dengan begitu pesatnya memberikan dampak yang cukup besar terhadap perilaku konsumen dalam memilih dan memutuskan untuk melakukan transaksi jual beli. Teknologi Informasi telah memungkinkan berbagai kegiatan dapat dilaksanakan dengan cepat, tepat dan akurat, tidak dibatasi oleh waktu dan tempat sehingga diharapkan dapat meningkatkan kinerja dan produktivitas. Peningkatan jumlah pengguna internet di Indonesia dari 30 juta orang pada tahun 2009 menjadi 171 juta orang pada tahun 2018 perlu disikapi dengan bijak khususnya bagi perusahaan yang ingin memenangkan persaingan bisnis. Perubahan perilaku konsumen terkait dengan cara memperoleh informasi dan melakukan transaksi jual beli harus dikaji ulang secara terus menerus agar diperoleh informasi yang tepat mengenai keinginan dan kebutuhan konsumen. Penelitian ini dilakukan untuk mengetahui perilaku konsumen dalam melakukan aktifitasnya khususnya aktifitas jual beli sebagai akibat perkembangan teknologi informasi dan telekomunikasi. Penelitian dilakukan dengan menggunakan kuisioner yang dilakukan secara online (online) agar bisa menjangkau responden yang lebih banyak, lebih beragam, lebih luas sebarannya dan dalam waktu yang lebih cepat. Hasil penelitian menunjukkan adanya ketergantungan masyarakat terhadap internet yang berakibat adanya perubahan cara mendapatkan informasi dan perubahan perilaku dalam melakukan jual beli yang semula dilakukan secara offline menjadi online.
PERANCANGAN SISTEM INFORMASI GEOGRAFIS PARIWISATA DI JOMBANG BERBASIS MOBILE (STUDI KASUS : DINAS PARIWISATA JOMBANG)
Authors: Huda Ahmad Nur Syahril , Balafif Nufan , Murtadho Mohamad Ali 
Published: May 2021

Sistem Informasi Geografis (SIG) dibuat dengan menggunakan informasi yang berasal dari pengolahan sejumlah data, yaitu data yang berkaitan dengan posisi objek di permukaan bumi. Di kabupaten Jombang, juga memiliki tempat wisata yang banyak dikunjungi masyarakat dihampir seluruh Indonesia yakni : wisata makam Gusdur, dan kedung cinet yang sempat masuk salah satu Channel TV yaitu Tranz TV dengan sebutan Grand Canyon Jombang. Permasalahan dari wisata yang ada di Jombang adalah arah penunjuk ke lokasi wisata serta wisata-wisata baru yang belum di ketahui oleh wisatawan baik local maupun dari manca negara. Sehingga terjadi keluhan dari wisatawan serta kurangnya pengelolaan data wisata dari Dinas Pariwisata Budaya Pemuda dan Olahraga Jombang karena banyaknya wisata yang belum terdaftar di Dinas terkait. Dari permasalahan tersebut muncul suatu gagasan untuk membangun suatu Sistem Informasi Geografis Pariwisata Jombang dibangun Menggunakan Metodelogi waterfall, dengan bahasa pemograman PHP , HTML, Jquery, sedangkan untuk database-nya menggunakan MySQL, Selain itu dalam proses prancangan aplikasi ini menggunakan UML, Berdasarkan hasil analisis dan pengujian dengan mengunakan Black Box Testing. Disimpulkan bahwa sistem informasi geografis pariwisata jombang berbasis mobile dapat digunakan sebagai salah satu solusi untuk dinas pariwisata dalam mempromosikan wisata yang ada di Jombang. Serta di dalam aplikasi ini terdapat fitur tambah data (wisata,kuliner,penginapan, dan dapat melihat deskripsi lokasi wisata. Hasil dari penerapan aplikasi Memudahkan pihak dinas untuk memberikan informasi wisata dan memudahkan wisatawan dalam mengetahui lokasi dan jarak tempu wisata.
Native microbial consortia improve maize shoot and root systems at early developmental stages in a seedbed assay
Authors: Guardiola-Márquez Carlos Esteban , Figueroa-Montes Melina Lizeth , Pacheco Moscoa Adriana , Senés-Guerrero Carolina 
Published: May 2021

Background: Agriculture is a major contributor to environmental and soil degradation. Soil microorganisms are essential to improve plant growth, crop yields and stress-tolerance.
Objective: To characterize maize early plant-response in a seedbed setting to native consortia of isolated microorganisms from arid zones.
Methods: Sixteen fungal and 16 bacterial isolates from arid soils were identified by MALDI-TOF MS and confirmed using morphological characteristics. Ten biofertilizers were tested in replicates (n=100) in maize under seedbed conditions. Consortia were formulated based on growth promoting traits, including mainly Penicillium and Pseudomonas species. After 45 days, biofertilizers were evaluated according to plant height, and shoot and root fresh weight.
Results and Conclusions: Penicillium and Pseudomonas were the predominant genera identified. Most strains are potential candidates for biofertilizer formulation based on their growth promoting traits. Bacterial consortia mainly promoted plant caulinar development, while the combination of fungal and bacterial species markedly increased root development. Eight biofertilizer consortia from arid zones had positive effects at early developmental stage of maize under seedbed conditions compared to uninoculated plants.
Gender- and Age-Specific Associations of Visit-to-Visit Blood Pressure Variability With Anxiety
Authors: Zhou Jiandong , Lee Sharen , Wong Wing Tak , Leung Keith Sai Kit , Nam Ronald Hang Kin , Leung Prudence Shun Hay , Chau Yau-Lam Alex , Liu Tong , Chang Carlin , Cheung Bernard Man Yung , Tse Gary , Zhang Qingpeng 
Published: May 2021

Background: There is a bidirectional relationship between blood pressure variability (BPV) and anxiety, but few studies have examined the gender- and age-specific effects of visit-to-visit BPV on incident anxiety. We examined the predictive value of BPV for the incidence of anxiety in a family clinic cohort.Methods: Consecutive patients with a first attendance to family medicine clinics in Hong Kong between January 1, 2000, and December 31, 2002, with at least three blood pressure measurements available thereafter were included. The primary endpoint was incident anxiety as identified by ICD-9 coding.Results: This study included 48,023 (50% males) patients with a median follow-up of 224 [interquartile range (IQR): 217–229] months. Females were more likely to develop incident anxiety compared to males (incidence rate: 7 vs. 2%), as were patients of older age. Significant univariate predictors were female gender, older age, preexisting cardiovascular diseases, respiratory diseases, diabetes mellitus, hypertension, and gastrointestinal diseases, various laboratory examinations, and the number of blood pressure measurements. Higher baseline, maximum, minimum, standard deviation (SD), coefficient of variation (CV), and variability score of diastolic blood pressure significantly predicted incident anxiety, as did all systolic blood pressure measures [baseline, latest, maximum, minimum, mean, median, variance, SD, root mean square (RMS), CV, and variability score].Conclusions: The relationships between longer-term visit-to-visit BPV and incident anxiety were identified. Female and older patients with higher blood pressure and higher BPV were at the highest risks of incident anxiety.
A20/TNFAIP3 Increases ENOS Expression in an ERK5/KLF2-Dependent Manner to Support Endothelial Cell Health in the Face of Inflammation
Authors: Angolano Cleide , Kaczmarek Elzbieta , Essayagh Sanah , Daniel Soizic , Choi Lynn Y. , Tung Brian , Sauvage Gabriel , Lee Andy , Kipper Franciele C. , Arvelo Maria B. , Moll Herwig P. , Ferran Christiane 
Published: May 2021

Rationale: Decreased expression and activity of endothelial nitric oxide synthase (eNOS) in response to inflammatory and metabolic insults is the hallmark of endothelial cell (EC) dysfunction that preludes the development of atherosclerosis and hypertension. We previously reported the atheroprotective properties of the ubiquitin-editing and anti-inflammatory protein A20, also known as TNFAIP3, in part through interrupting nuclear factor-kappa B (NF-κB) and interferon signaling in EC and protecting these cells from apoptosis. However, A20's effect on eNOS expression and function remains unknown. In this study, we evaluated the impact of A20 overexpression or knockdown on eNOS expression in EC, at baseline and after tumor necrosis factor (TNF) treatment, used to mimic inflammation.Methods and Results: A20 overexpression in human coronary artery EC (HCAEC) significantly increased basal eNOS mRNA (qPCR) and protein (western blot) levels and prevented their downregulation by TNF. Conversely, siRNA-induced A20 knockdown decreased eNOS mRNA levels, identifying A20 as a physiologic regulator of eNOS expression. By reporter assays, using deletion and point mutants of the human eNOS promoter, and knockdown of eNOS transcriptional regulators, we demonstrated that A20-mediated increase of eNOS was transcriptional and relied on increased expression of the transcription factor Krüppel-like factor (KLF2), and upstream of KLF2, on activation of extracellular signal-regulated kinase 5 (ERK5). Accordingly, ERK5 knockdown or inhibition significantly abrogated A20's ability to increase KLF2 and eNOS expression. In addition, A20 overexpression in HCAEC increased eNOS phosphorylation at Ser-1177, which is key for the function of this enzyme.Conclusions: This is the first report demonstrating that overexpression of A20 in EC increases eNOS transcription in an ERK5/KLF2-dependent manner and promotes eNOS activating phosphorylation. This effect withstands eNOS downregulation by TNF, preventing EC dysfunction in the face of inflammation. This novel function of A20 further qualifies its therapeutic promise to prevent/treat atherosclerosis.
Serum Uric Acid Concentrations and Risk of Adverse Outcomes in Patients With COVID-19
Authors: Chen Bo , Lu Chenyang , Gu Hong-Qiu , Li Yang , Zhang Guqin , Lio Jonathan , Luo Xiongyan , Zhang Lingshu , Hu Yidan , Lan Xiaomeng , Chen Zerong , Xie Qibing , Pan Huaqin 
Published: May 2021

BackgroundAlthough hyperuricemia frequently associates with respiratory diseases, patients with severe coronavirus disease 2019 (COVID-19) and severe acute respiratory syndrome (SARS) can show marked hypouricemia. Previous studies on the association of serum uric acid with risk of adverse outcomes related to COVID-19 have produced contradictory results. The precise relationship between admission serum uric acid and adverse outcomes in hospitalized patients is unknown.MethodsData of patients affected by laboratory-confirmed COVID-19 and admitted to Leishenshan Hospital were retrospectively analyzed. The primary outcome was composite and comprised events, such as intensive care unit (ICU) admission, mechanical ventilation, or mortality. Logistic regression analysis was performed to explore the association between serum concentrations of uric acid and the composite outcome, as well as each of its components. To determine the association between serum uric acid and in-hospital adverse outcomes, serum uric acid was also categorized by restricted cubic spline, and the 95% confidence interval (CI) was used to estimate odds ratios (OR).ResultsThe study cohort included 1854 patients (mean age, 58 years; 52% women). The overall mean ± SD of serum levels of uric acid was 308 ± 96 µmol/L. Among them, 95 patients were admitted to ICU, 75 patients received mechanical ventilation, and 38 died. In total, 114 patients reached composite end-points (have either ICU admission, mechanical ventilation or death) during hospitalization. Compared with a reference group with estimated baseline serum uric acid of 279-422 µmol/L, serum uric acid values ≥ 423 µmol/L were associated with an increased risk of composite outcome (OR, 2.60; 95% CI, 1.07- 6.29) and mechanical ventilation (OR, 3.01; 95% CI, 1.06- 8.51). Serum uric acid ≤ 278 µmol/L was associated with an increased risk of the composite outcome (OR, 2.07; 95% CI, 1.18- 3.65), ICU admission (OR, 2.18; 95% CI, 1.17- 4.05]), and mechanical ventilation (OR, 2.13; 95% CI, 1.06- 4.28), as assessed by multivariate analysis.ConclusionsThis study shows that the association between admission serum uric acid and composite outcome of COVID-19 patients was U-shaped. In particular, we found that compared with baseline serum uric acid levels of 279-422 µmol/L, values ≥ 423 µmol/L were associated with an increased risk of composite outcome and mechanical ventilation, whereas levels ≤ 278 µmol/L associated with increased risk of composite outcome, ICU admission and mechanical ventilation.
Monitoring Spatial-Temporal Transition Dynamics of Transport Infrastructure Space in Urban Growth Phenomena: A Case Study of Lagos—Nigeria
Authors: Otuoze Suleiman Hassan , Hunt Dexter V.L. , Jefferson Ian 
Published: May 2021

Lagos is one of the fastest growing world mega-cities with a huge urban mobility crisis, the traditional aggregate city’s development model could not provide reliable scientific solutions to monitor the competing demands of various land-use components and the urbanization’s effects on transport infrastructure space. This study uses a disaggregated predictive spatial modeling approach to investigate the evolutionary dynamics of transportation infrastructure space to address the fragmented urban chain process. The methodology involves analysis and modeling of the land-use spatial transition changes that have occurred over the past three decades using three Landsat imagery epochs (1984, 2013, and 2019) in remote sensing ARC-GIS 10.7. Furthermore, the prediction of the two-temporal milestones (2030 and 2050) using hybrid cellular automata-Markov (CA-Markov) implemented in IDIRISI SELVA 17.0 software when the tides of social-demographic factors were expected to bring about significant urban spatial transformation. The forecast results are expected to increase the area for transport infrastructure spaces by 93 km2 (7.3%) in 2030 and 157 km2 (12.4%) in 2050. The model’s kappa reliability coefficient estimates for the three temporal scales (k1984 = 85%; k2013 = 88% and k2019 = 89%) are higher than the 80% minimum adjudged strong agreement between the ground truth and prediction classified images in literature. The model provides efficient tool in urban development planning and sustainable transport decisions.
Combination of Immunotherapy and Radiotherapy for Recurrent Malignant Gliomas: Results From a Prospective Study
Authors: Jiang Haihui , Yu Kefu , Cui Yong , Ren Xiaohui , Li Mingxiao , Yang Chuanwei , Zhao Xuzhe , Zhu Qinghui , Lin Song 
Published: May 2021

BackgroundWorld Health Organization (WHO) grade IV glioma remains one of the most lethal tumors with a dismal prognosis and inevitable recurrence. We evaluated the safety and efficacy of immunotherapy with radiotherapy in this population of patients.MethodsThis study was a single-arm, open-label, phase I trial based on patients with recurrent WHO grade IV glioma. Patients were treated with intracranial and systemic immunoadjuvants in combination with low-dose reirradiation. The primary endpoint of the present trial was safety. Secondary endpoints were overall survival (OS) and progression-free survival (PFS). This trial is registered at ClinicalTrials.gov, NCT03392545.ResultsThirty patients were enrolled. The most common adverse events (AEs) were fever (66.7%), vomiting (33.3%), headache (30.0%), and fatigue (23.3%). Only a single patient experienced grade 3 fever, and no grade 4 AEs or deaths related to treatment were observed. Of the 30 patients, 1 (3.3%) had a complete response, 5 (16.7%) had a partial response, 9 (30.0%) had stable disease, and 15 (50.0%) had progressive disease, resulting in an objective response rate of 20.0%. The median PFS of the entire cohort was 88.0 (61.0-254.0) days, and the median OS was 362.0 (197.0-601.0) days. Patients could be divided into responders and non-responders, and these groups exhibited a significant difference in terms of survival time, T lymphocyte subsets, frequency of cell division cycle 27 (CDC27) mutation status, and CD15 and CD68 expression (P&lt;0.05).ConclusionThe combination of immunotherapy and radiotherapy is well tolerated and may provide clinical benefit for patients with recurrent WHO grade IV glioma. A prospective phase II study is needed to further validate the efficacy of our therapeutic regimen.
Altered Functional Connectivity of the Primary Visual Cortex in Patients With Iridocyclitis and Assessment of Its Predictive Value Using Machine Learning
Authors: Tong Yan , Huang Xin , Qi Chen-Xing , Shen Yin 
Published: May 2021

PurposeTo explore the intrinsic functional connectivity (FC) alteration of the primary visual cortex (V1) between individuals with iridocyclitis and healthy controls (HCs) by the resting-state functional magnetic resonance imaging (fMRI) technique, and to investigate whether FC findings be used to differentiate patients with iridocyclitis from HCs.MethodsTwenty-six patients with iridocyclitis and twenty-eight well-matched HCs were recruited in our study and underwent resting-state fMRI examinations. The fMRI data were analyzed by Statistical Parametric Mapping (SPM12), Data Processing and Analysis for Brain Imaging (DPABI), and Resting State fMRI Data Analysis Toolkit (REST) software. Differences in FC signal values of the V1 between the individuals with iridocyclitis and HCs were compared using independent two-sample t-tests. Significant differences in FC between two groups were chosen as classification features for distinguishing individuals with iridocyclitis from HCs using a support vector machine (SVM) classifier that involved machine learning. Classifier performance was evaluated using permutation test analysis.ResultsCompared with HCs, patients with iridocyclitis displayed significantly increased FC between the left V1 and left cerebellum crus1, left cerebellum 10, bilateral inferior temporal gyrus, right hippocampus, and left superior occipital gyrus. Moreover, patients with iridocyclitis displayed significantly lower FC between the left V1 and both the bilateral calcarine and bilateral postcentral gyrus. Patients with iridocyclitis also exhibited significantly higher FC values between the right V1 and left cerebellum crus1, bilateral thalamus, and left middle temporal gyrus; while they displayed significantly lower FC between the right V1 and both the bilateral calcarine and bilateral postcentral gyrus (voxel-level P&lt;0.01, Gaussian random field correction, cluster-level P&lt;0.05). Our results showed that 63.46% of the participants were correctly classified using the leave-one-out cross-validation technique with an SVM classifier based on the FC of the left V1; and 67.31% of the participants were correctly classified based on the FC of the right V1 (P&lt;0.001, non-parametric permutation test).ConclusionPatients with iridocyclitis displayed significantly disturbed FC between the V1 and various brain regions, including vision-related, somatosensory, and cognition-related regions. The FC variability could distinguish patients with iridocyclitis from HCs with substantial accuracy. These findings may aid in identifying the potential neurological mechanisms of impaired visual function in individuals with iridocyclitis.