bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genomic characteristics and prognostic significance of co‐mutatedASXL1/SRSF2acute myeloid leukemia
Authors: Richardson Daniel R. , Swoboda David M. , Moore Dominic T. , Johnson Steven M. , Chan Onyee , Galeotti Jonathan , Esparza Sonia , Hussaini Mohammad O. , Van Deventer Hendrick , Foster Matthew C. , Coombs Catherine C. , Montgomery Nathan D. , Sallman David A. , Zeidner Joshua F. 
Published: January 2021

AbstractTheASXL1andSRSF2mutations in AML are frequently found in patients with preexisting myeloid malignancies and are individually associated with poor outcomes. In this multi‐institutional retrospective analysis, we assessed the genetic features and clinical outcomes of 43 patients withASXL1mutSRSF2mutAML and compared outcomes to patients with eitherASXL1(n = 57) orSRSF2(n = 70) mutations. Twenty‐six (60%) had secondary‐AML (s‐AML). Variant allele fractions suggested thatSRSF2mutations precededASXL1mutational events. Median overall survival (OS) was 7.0 months (95% CI:3.8,15.3) and was significantly longer in patients with de novo vs s‐AML (15.3 vs 6.4 months, respectively;P= .04 on adjusted analysis). Compared toASXL1mutSRSF2wtandASXL1wtSRSF2mut, co‐mutated patients had a 1.4 and 1.6 times increase in the probability of death, respectively (P= .049), with a trend towards inferior OS (median OS = 7.0 vs 11.5 vs 10.9 months, respectively;P= .10). Multivariable analysis suggests this difference in OS is attributable to the high proportion of s‐AML patients in the co‐mutated cohort (60% vs 32% and 23%, respectively). Although this study is limited by the retrospective data collection and the relatively small sample size, these data suggest thatASXL1mutSRSF2mutAML is a distinct subgroup of AML frequently associated with s‐AML and differs fromASXL1mutSRSF2wt/ASXL1wtSRSF2mutwith respect to etiology and leukemogenesis.
Genetic skin disorders: The value of a multidisciplinary clinic
Authors: Parker James Clayton , Rangu Sneha , Grand Katheryn Lynn , Bhoj Elizabeth Joyce , Castelo‐Soccio Leslie , Sheppard Sarah E. 
Published: January 2021

AbstractGenodermatoses are inherited disorders with skin manifestations and can present with multisystem involvement, resulting in challenges in diagnosis and treatment. To address this, the expertise of dermatology and clinical genetics through a multidisciplinary clinic (Genodermatoses Clinic) were combined. A retrospective cohort study of 45 children seen between March 2018 and February 2019 in the Genodermatoses Clinic at The Children's Hospital of Philadelphia was performed. Patient demographics, referral information, genetic testing modality, diagnoses, and patient satisfaction scores were evaluated to assess the clinic's impact. The majority of patients (42.2%) were referred from Dermatology and 86.7% were referred for diagnosis. Two‐thirds of the patients were recommended genetic testing, and subsequently 73.3% completed testing. Nearly three‐quarters, 26 out of 36 patients (72.2%), of our undiagnosed patients received a clinical and/or molecular diagnosis, which is imperative in managing their care. Twenty‐two individuals pursued genetic testing. In eight individuals (36%), molecular testing was diagnostic. However, in two individuals the molecular diagnosis did not completely explain the phenotype. However, there are still obstacles to genetic testing, such as cost of testing and insurance barriers. Almost all (91.4%) rated the Genodermatoses Clinic as “Very Good,” the top Press Ganey score. High patient satisfaction scores suggest a positive impact of the Genodermatoses clinic, emphasizing the importance to increase support for the clinical and administrative time needed for patients with genodermatoses.
Recent Advances in the Synthesis of CF3‐ or HCF2‐Substituted Cyclopropanes
Authors: Wu Wen‐Feng , Lin Jin‐Hong , Xiao Ji‐Chang , Cao Yu‐Cai , Ma Yanfang 
Published: January 2021

AbstractCF3‐ or HCF2‐substituted cyclopropanes are of great interest in pharmaceutical chemistry and agrochemistry, and thus significant efforts have been directed towards the development of efficient methods for the installation of these motifs. This Minireview summarizes recent efforts for the construction of CF3‐ or HCF2‐substituted cyclopropanes. CF3‐cyclopropanes are usually synthesized by a transition‐metal‐catalyzed cyclopropanation of alkenes with a trifluoromethylcarbene generated in situ from a diazocompound, CF3CHN2 or CF3C(Ar)N2. The synthesis of HCF2‐cyclopropanes remains largely unexplored. Some difluoromethylcarbene reagents have been developed, such as HCF2CHN2, Ph2S+CH2CF2H TfO−, and difluoroacetaldehyde N‐triftosylhydrazone (DFHZ‐Tfs), and cyclopropanation of alkenes with these reagents could also occur by transition metal catalysis. These protocols may find great utility in the synthesis of biologically active molecules.
C3h‐symmetric and Cs‐symmetric Triformyl Triindolo‐Truxenes: Synthesis and Properties
Authors: Chen Jun‐Bo , Lu Ru‐Qiang , Wang Xin‐Chang , Qu Hang , Liu Hao‐Liang , Zhang Hui , Cao Xiao‐Yu 
Published: January 2021

AbstractC3h‐symmetric and Cs‐symmetric triformyl triindolo‐truxenes with different substitution positions of formyl groups were developed by two synthetic strategies. Direct formylation of triindolo‐truxene using Rieche formylation produced C3h‐symmetric and Cs‐symmetric triformyl triindolo‐truxenes in one‐pot. Four‐step synthesis starting from truxene gave a carbonyl‐modified C3h‐symmetric triformyl triindolo‐truxene. The optical and electrochemical properties of triformyl triindolo‐truxenes were modulated by changing the substitution positions of formyl groups and introducing carbonyl groups into molecules. The Cs‐symmetric triformyl triindolo‐truxenes exhibited red‐shifted absorption and emission, higher HOMO levels, and narrower HOMO‐LUMO gaps than those of C3h‐symmetric analogues. Furthermore, carbonyl‐modified C3h‐symmetric triformyl triindolo‐truxene showed the longest absorption and emission and narrowest HOMO‐LUMO gap among its analogues. The assembly of triformyl triindolo‐truxenes in single crystals and solution was investigated. This work provides valuable building blocks for constructing supramolecular architectures and adds new aspects of reactivity and structure‐property relationship of triindolo‐truxene.
FeCl2‐Catalyzed Direct C2‐Benzylation of Benzofurans with Diarylmethanes via Cross Dehydrogenative Coupling
Authors: Zhou Jiacheng , Li Tianci , Li Meichao , Li Chunmei , Hu Xinquan , Jin Liqun , Sun Nan , Hu Baoxiang , Shen Zhenlu 
Published: January 2021

AbstractA direct strategy for the iron‐catalyzed oxidative coupling C2‐functionalization of benzofurans with unactivated diarylmethanes has been established. The developed procedure provides a straightforward access to C2‐benzylation of benzofurans from simple and abundant starting materials without the need for pre‐functionalization or specific substituted functional groups of both, substrates and coupling partners.
Non‐oxidative Coupling of Methane: N‐type Doping of Niobium Single Atoms in TiO2–SiO2 Induces Electron Localization
Authors: Chen Ziyu , Wu Shiqun , Ma Jiayu , Mine Shinya , Toyao Takashi , Matsuoka Masaya , Wang Lingzhi , Zhang Jinlong 
Published: January 2021

AbstractPhotodriven nonoxidative coupling of CH4 (NOCM) is an attractive potential way to use abundant methane resources. Herein, an n‐type doped photocatalyst for NOCM is created by doping single‐atom Nb into hierarchical porous TiO2–SiO2 (TS) microarray, which exhibits a high conversion rate of 3.57 μmol g−1 h−1 with good recyclability. The Nb dopant replaces the 6‐coordinated titanium on the (1 0 1) plane and forms shallow electron‐trapped surface polarons along [0 1 0] direction and the comparison of different models proves that the electron localization caused by the n‐type doping is beneficial to both methane activation and ethane desorption. The positive effect of n‐type dopant on CH4 conversion is further verified on Mo‐, W‐ and Ta‐doped composites. In contrast, the doping of p‐type dopant (Ga, Cu, Fe) shows a less active influence.
Coassemblierung von Helices auf Makroebene durch chiralitätstransferierende, temperaturresponsive, Kohlenhydrat‐basierte Bolaamphiphile und 1,4‐Phenylenbisboronsäure
Authors: Wang Shuang , Forster Marcel C. , Xue Kai , Ehlers Florian , Pang Bo , Andreas Loren B. , Vana Philipp , Zhang Kai 
Published: January 2021

AbstractWir zeigen das erste Beispiel von Helices, die durch temperaturresponsive, Kohlenhydrat‐basierte Bolaamphiphile (CHO‐Bolas) und 1,4‐Phenylenbisboronsäure (BDBA) auf der Makroskala coassembliert wurden. Die CHO‐Bolas enthielten hydrophile Glucose‐ oder Mannose‐Einheiten und ein hydrophobes Cumarin‐Dimer. Sie zeigten in wässriger Lösung einen reversiblen, temperaturresponsiven Mizellen‐zu‐Vesikel‐Übergang (MVT). Nach dem Binden der Kohlenhydrat‐Einheiten mit den Boronsäure‐Gruppen des BDBA in alkalischer Lösung wurden rechtshändige Helices über einen temperaturgetriebenen Chiralitätstransfer der d‐Glucose oder d‐Mannose von der molekularen auf die supramolekularen Ebene gebildet. Diese Helices wurden durch nicht umgesetztes BDBA, aus CHO‐Bolas und BDBA gebildete Boronsäureester (B‐O‐C‐Bindungen) sowie Boroxinanhydride (B‐O‐B) aus der Selbstkondensation von BDBA coassembliert. Nach Erhitzen bei 300 °C unter Stickstoff zeigten die Helices eine exzellente morphologische Stabilität. Darüber hinaus emittierten sie helle, blaue Lumineszenz infolge von starker Selbstkondensation des BDBA und Zerfall des Cumarin‐Dimers.
Fine‐Tuning the Spring‐Like Motion of an Anion‐Based Triple Helicate by Tetraalkylammonium Guests
Authors: Liang Lin , Li Boyang , Zhang Wenyao , Li Anyang , Zheng Bo , Yang Xiao‐Juan , Wu Biao 
Published: January 2021

AbstractSupramolecular springs are a class of molecular devices that may provide implications to the macroscopic spring behavior from the molecular level. Helical structures are suitable molecular springs because the specific twisting of the helical strands can cause spring‐like (extension‐contraction) movement along the axis upon external stimuli. Herein we report an anion‐based triple‐helicate spring, which can undergo reversible contraction–extension motion through introduction and removal of tetraalkylammonium cations, including TMA+ and analogous irregular tetrahedral cations bearing different alkyl chains, while the relative orientation of the two phosphate ions changes to facilitate guest inclusion. Notably, the degree of contraction (shortening of the helical pitch) can be fine‐tuned by varying the shape and size of guest cation. However, with the larger cations (TEA+, TPA+ and TBA+), the meso‐helicate configuration is obtained, which interconverts with the helicate by addition/removal of TMA+ ion.
Rechargeable K‐CO2 Batteries with a KSn Anode and a Carboxyl‐Containing Carbon Nanotube Cathode Catalyst
Authors: Lu Yong , Cai Yichao , Zhang Qiu , Ni Youxuan , Zhang Kai , Chen Jun 
Published: January 2021

AbstractMetal K‐CO2 batteries suffer from large polarization and safety hazards, which mainly result from the difficult decomposition of K2CO3 and dendrite growth. Moreover, the battery redox mechanism remains not fully understood. Here we report K‐CO2 batteries with KSn alloy as the anode and carboxyl‐containing multi‐walled carbon nanotubes (MWCNTs‐COOH) as the cathode catalyst, proving the redox mechanism to be 4 KSn + 3 CO2 ⇄ 2 K2CO3 + C + 4 Sn. Compared with K metal, the less active and dendrite‐free KSn anode effectively enhances the safety and stability of CO2 batteries. More importantly, the strong electrostatic interaction between MWCNTs‐COOH and K2CO3 weakens the C=O bond in K2CO3 and thus facilitates K2CO3 decomposition. As a result, the K‐CO2 batteries show excellent cycling stability (an overpotential increase of 0.89 V after 400 cycles) and good rate performance (up to 2000 mA g−1). This work paves a way to develop highly stable and safe CO2‐based batteries.
Macroscalar Helices Co‐Assembled from Chirality‐Transferring Temperature‐Responsive Carbohydrate‐Based Bolaamphiphiles and 1,4‐Benzenediboronic Acid
Authors: Wang Shuang , Forster Marcel C. , Xue Kai , Ehlers Florian , Pang Bo , Andreas Loren B. , Vana Philipp , Zhang Kai 
Published: January 2021

AbstractWe present the first example of macroscalar helices co‐assembled from temperature‐responsive carbohydrate‐based bolaamphiphiles (CHO‐Bolas) and 1,4‐benzenediboronic acid (BDBA). The CHO‐Bolas contained hydrophilic glucose or mannose moieties and a hydrophobic coumarin dimer. They showed temperature‐responsive reversible micelle‐to‐vesicle transition (MVT) in aqueous solutions. After the binding of carbohydrate moieties with boronic acids of BDBA in their alkaline solutions, right‐handed helices were formed via the temperature‐driven chirality transfer of d‐glucose or d‐mannose from the molecular to supramolecular level. These helices were co‐assembled by unreacted BDBA, boronate esters (B−O−C bonds) between CHO‐Bolas and BDBA, as well as boroxine anhydrides (B−O−B bonds) of self‐condensed BDBA. After heating at 300 °C under nitrogen, the helices displayed excellent morphological stability. Moreover, they emitted bright blue luminescence caused by strong self‐condensation of BDBA and decomposition of coumarin dimers.
Nanostructured rigid polyurethane foams with improved specific thermo‐mechanical properties using bacterial nanocellulose as a hard segment
Authors: Benavides Sofía , Armanasco Franco , Cerrutti Patricia , Chiacchiarelli Leonel Matías 
Published: January 2021

AbstractRigid polyurethane foams (RPUFs) were synthesized with bacterial nanocellulose (BNC) at concentrations of up to 0.5 wt% using two insertion routes based on its reaction with the isocyanate precursor (ISO route) and the formation of a colloidal dispersion in the polyol precursor (POL route). The results indicated that, for BNC concentrations of only 0.1 wt%, drastic improvements of the specific elastic compressive modulus (+244.2%) and strength (+77.5%) were measured for foams with apparent density of 46.4+/− 4.7 Kg.m−3. The chemical reaction of BNC with the precursor was corroborated through the measurement of the isocyanate number and FTIR analysis. The BNC caused a significant nucleation effect, decreasing the cell size up to 39.7%. Differential scanning calorimetry analysis revealed that the BNC had a strong effect on post‐cure enthalpy, particularly for the POL route. Dynamical mechanical thermal analysis under flexural conditions proved that, regardless of BNC concentration, the incorporation of BNC caused anisotropy and that the ISO route contributed to an enhanced damping factor at high temperatures. These results prove that the ISO route is a key aspect to achieve foamed nanocomposites with improved specific mechanical properties.
Dielectric performance of composites of BaTiO3 and polymers for capacitor applications under microwave frequency
Authors: Basturk S. Bahar , Dancer Claire E. J. , McNally Tony 
Published: January 2021

AbstractComposites of nano‐sized barium titanate (BaTiO3) with volume fractions up to 0.5 and poly(butylene terephthalate) (PBT) or linear low‐density polyethylene (LLDPE) were made via extrusion. Scanning electron microscopy demonstrated that BaTiO3 is well dispersed in the polymer matrices. The crystalline content (DSC) and thermal stability (TGA) of both polymers decreased with increasing BaTiO3 loading. Dielectric properties of the composites were measured using a vector network analyzer. Both dielectric permittivity and tangent loss increased with increasing BaTiO3 content. At 2.45 GHz, the dielectric permittivity for 48 vol% BaTiO3‐filled LLDPE and 43 vol% BaTiO3‐filled PBT was 25 and 21.2, respectively. There was a good fit between the Lichtenecker model and experimental data obtained up to a certain value, with the permittivity variations being dependent on volume fraction. The improved dielectric performance achieved on inclusion of BaTiO3 confirms both composite systems as potential candidates for microwave frequency capacitor applications.
Geophysical survey at the early Christian complex of Son Peretó (Mallorca, Balearic Islands, Spain)
Authors: Mas Florit Catalina , Cau Ontiveros Miguel Ángel , Meyer Cornelius , Sala Roger , Ortiz Helena , RodrÍguez Simón Pedro 
Published: January 2021

AbstractRural basilicas are the most important evidence of Christianization of the countryside on the island of Mallorca (Balearic Islands, Spain). Recent investigations of rural landscape transformations suggest that some churches were built along communication routes and linked to preexisting settlements. To obtain new data that could support this hypothesis, a geophysical survey has been carried out at the early Christian complex of Son Peretó, one of the most emblematic sites for the understanding of Late Antiquity on the island. The objective was to better define the site investigating the possible presence of other remains related to the Christian complex, that is undergoing excavation, or to a previous settlement that was later Christianized. The geophysical survey was carried out combining magnetometry and ground‐penetrating radar. For the magnetic investigation, a multiprobe gradiometer array was used. GPR was used to examine the areas nearby the remains already excavated and to better define areas where the magnetic data revealed interesting anomalies. GPR data were collected using an IDS GPR system. The results revealed both the presence of architectural remains beneath the soil that help define the Early Christian complex, as well as other remains that suggest the church was part of a larger settlement.
How online review richness impacts sales: An attribute substitution perspective
Authors: Yin Hang , Zheng Shuang , Yeoh William , Ren Jie 
Published: January 2021

AbstractRicher forms of online reviews such as videos or follow‐on reviews convey ‘additional information and can attract consumers’ attention. However, prior studies focused mostly on the relationship between aggregated online reviews and sales. This paper investigates the impact of online review richness (i.e., reviews containing videos or follow‐on reviews) on sales. Leveraging attribute substitution theory, we conjecture that online review richness can provide heuristic cues in the online shopping environment to help consumers make better purchase decisions. Using data from JD.com, we found that reviews containing either videos or follow‐on reviews positively affect sales. In addition, different product types can also serve as heuristic cues to replace target cues, which can further affect how different forms of online review richness affect sales. We found that the impact of online review richness on sales is stronger for utilitarian products than for hedonic products, and stronger for negatively commented products than for positively commented products. Moreover, we conducted two online experiments and confirmed that the causal relationship is from online review richness to sales. The research findings offer practical implications for online retailers and constitute one of the first steps toward a better understanding of the relationship between online review richness and sales.
Icaritin and icariin reduce p‐Tau levels in a cell model of Alzheimer's disease by downregulating glycogen synthase kinase 3β
Authors: Li Ying , Dai Shirui , Huang Nanqu , Wu Jie , Yu Changyin , Luo Yong 
Published: January 2021

AbstractThis study aimed to explore the neuroprotective effect of icariin/icaritin (ICA/ICT) and the role of ICA/ICT in the treatment of Alzheimer's disease (AD). ICA and ICT were used to treat okadaic acid (OA)‐induced Tau hyperphosphorylation in SH‐SY5Y cells. We detected the relative changes in Tau, p‐Tau, protein phosphatase 2A (PP2A), and glycogen synthase kinase 3β (GSK‐3β) by Western blotting and enzyme‐linked immunosorbent assay. At 40 nmol/L OA, the cell viability of the SH‐SY5Y cells was significantly changed. We used different concentrations of ICA and IC to treat AD model cells and found that the effect of 2.5 μmol/L ICA and 1 μmol/L ICT was best after 48 H of treatment. After SH‐SY5Y cell induction, the p‐Tau levels were increased (P < 0.05); after the ICA/ICT treatment, the p‐Tau and GSK‐3β levels were decreased (P < 0.05), although PP2A expression did not change (P > 0.05). We found that ICA and ICT exert an effect on AD model cells by decreasing the levels of GSK‐3β and p‐Tau. The therapeutic effect of ICT is slightly better than that of ICA. Although these drugs were effective in the cell model, more studies are required to determine whether they are promising for the treatment and prevention of AD.
Use of 5‐Thio‐L‐Fucose to modulate binding affinity of therapeutic proteins
Authors: Zimmermann Martina , Nguyen Melanie , Schultheiss Christian M. , Kolmar Harald , Zimmer Aline 
Published: January 2021

AbstractThe reduction of antibody core‐fucosylation is known to enhance antibody‐dependent cellular cytotoxicity (ADCC). In this study, 5‐Thio‐l‐Fucose (ThioFuc) was investigated as a media and feed supplement for modulating the fucosylation profile of therapeutic proteins and, thereby, improving the resulting effector functions. Glycan analysis of five different therapeutic proteins produced by a diverse set of Chinese hamster ovary cell lines demonstrated a clone dependent impact of ThioFuc treatment. Using rituximab as a model, an efficient dose‐ and time‐dependent reduction of core‐fucosylation up to a minimum of 5% were obtained by ThioFuc. Besides a concomitant increase in the afucosylation level up to 48%, data also revealed up to 47% incorporation of ThioFuc in place of core‐fucosylation. In accordance with the glycan data, antibodies produced in the presence of ThioFuc revealed an enhanced FcγRIIIa binding up to 7.7‐fold. Furthermore, modified antibodies subjected to a cell‐based ADCC reporter bioassay proved to exert both a 1.5‐fold enhanced ADCC efficacy and 2.6‐fold enhancement in potency in comparison to their native counterparts—both of which contribute to an improvement in the ADCC activity. In conclusion, ThioFuc is a potent fucose derivative with potential applications in drug development processes.
Study of rapid reorganization of visual neurofunctions with the resting‐state functional MRI in pituitary adenoma patients with vision improvement after transsphenoidal surgery
Authors: Wang Fuyu , Wang Peng , Liu Yuyang , Zhou Tao , Meng Xianghui , Jiang Jinli 
Published: January 2021

AbstractIntroductionTo investigate changes of vision‐related resting‐state activity in pituitary adenoma (PA) patients with visual improvement after transsphenoidal surgery.Methods14 PA patients with visual improvement after surgery were enrolled. The resting‐state functional MRI and neuro‐ophthalmologic evaluation were performed before and after the operation. The functional connectivity (FC) of 8 seeds (the primary visual cortex (V1), the secondary visual cortex (V2), the middle temporal visual cortex (MT+), and fusiform gyrus(FG)) was evaluated. A paired t test was conducted to identify the differences between the two groups.ResultsCompared with the preoperation counterparts, the PA patients with improved vision exhibited decreased FC with the V1, V2, MT+, FG in the left paracentral lobule, bilateral lingual gyrus, precentral gyrus(BA 4), right superior temporal gyrus(BA 22), left fusiform gyrus, bilateral middle occipital gyrus (BA 19), left cuneus, right inferior occipital gyrus, left superior frontal gyrus, right cuneus, left superior parietal lobule(BA 7),the medulla, right postcentral gyrus, and increased FC in the right middle frontal gyrus, left inferior parietal lobule (BA 40), left declive, right lentiform nucleus, inferior frontal gyrus, right superior frontal gyrus(BA 11), cingulate gyrus(BA 32), right putamen, right thalamus, left medial frontal gyrus, left claustrum, left superior frontal Medial, right rectal gyrus(BA 25) and right parahippocampal gyrus.ConclusionsThe results show most subareas within the visual cortex exhibit decreased functional connectivity. The functional changes in subareas within default mode network (DMN), action observation network (AON) and the multisensory system in PAs propose that vision improvement may lead to function remodeling in higher‐order cortex.