bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulation of cGAS-STING pathway - Implications for systemic lupus erythematosus
Authors: Hagiwara Audrey M. , Moore Richard E. , Wallace Daniel J. , Ishimori Mariko , Jefferies Caroline A. 
Published: December 2021

Abstract
Type I interferon (IFN-I) is implicated in the pathogenesis of systemic lupus erythematosus (SLE) and the closely associated monogenic autoinflammatory disorders termed the “interferonopathies.” Recently, the cytosolic DNA sensor cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) and its downstream signaling adaptor stimulator of interferon genes (STING) have been identified as having important, if not central, roles in driving IFN-I expression in response to self-DNA. This review highlights the many ways in which this pathway is regulated in order to prevent self-DNA recognition and underlines the importance of maintaining tight control in order to prevent autoimmune disease. We will discuss the murine and human studies that have implicated the cGAS-STING pathway as being an important contributor to breakdown in tolerance in SLE and highlight the potential therapeutic application of this knowledge for the treatment of SLE.
Trajetórias educacionais de estudantes universitários com dislexia
Authors: Jesus Karlla Vanessa Santos de , Nóbrega Danielle Oliveira da 
Published: December 2021

Este artigo tem o intuito de discutir as trajetórias escolares de dois/duas jovens do curso de Psicologia de uma universidade pública do interior do Nordeste do Brasil que manifestaram problemas de leitura e escrita e são diagnosticados com dislexia. Tem como base uma pesquisa que objetivou compreender as trajetórias educacionais desses/as estudantes a partir de suas narrativas autobiográficas. Trata-se de uma pesquisa qualitativa com fundamento na Psicologia Sócio-histórica, que utilizou como método de investigação as narrativas autobiográficas exploradas por meio de uma entrevista em profundidade. A partir da técnica de análise de conteúdo, obteve-se quatro categorias: trajetória educacional; experienciação da aprendizagem; processo de medicalização; e relações interpessoais. Com os resultados, observa-se que a trajetória educacional desses/as estudantes foi cercada por dificuldades que implicaram em questões relacionadas às condições de ensino, às relações familiares e às relações com professores/as. Conclui-se, questionando a medicalização das trajetórias escolares desses/as estudantes e sinalizando a relevância de programas de assistência estudantil que considerem as diversas formas de aprender.

Recebido: 05/06/2020Aceite: 22/12/2020
Assessment of active citizenship
Authors: Enchikova Ekaterina , Neves Tiago , Ferreira Pedro 
Published: December 2021

Active Citizenship (AC) is a complex and multidimensional notion that encompasses related constructs, such as civic and political engagement, civic competency, citizens’ identity, democratic values, among others. However, different studies offer different models of AC, focusing on specific aspects of it. In this paper, we focus on the research instruments used in the large international studies of AC, as they reflect how the constructs are understood and interpreted by different authors. This paper reviews the frameworks and the surveys of seven studies of AC to elaborate a comprehensive conceptual framework that incorporates different dimensions, signposts the main domains, and defines the relationships between them. This paper elucidates the current views on the operationalization of AC and can be used not only to develop instruments for future AC assessment, but also to provide a context for better understanding and interpretating current studies.

Recebido: 16/11/2019Aceite: 10/10/2020
Entre o TDAH e o aprimoramento cognitivo
Authors: Gonçalves Cristiana de Siqueira , Pedro Rosa Maria Leite Ribeiro 
Published: December 2021

O presente artigo visa desdobrar as controvérsias do diagnóstico de TDAH (Transtorno do Déficit de Atenção e Hiperatividade) e de seu tratamento medicamentoso através do cloridrato de metilfenidato. Controvérsias relacionadas à demanda por assistência médica que, advindas da escola e/ou dos pais diante de dificuldades no âmbito escolar, nos fazem questionar se estaríamos medicalizando o mau desempenho escolar. São controvérsias alimentadas pelo aumento no número de diagnósticos e pelo modo de prescrição do cloridrato de metilfenidato, que apontam para uma busca que diz respeito ao aprimoramento da performance escolar, mais do que ao tratamento de uma patologia. E que também estão vinculadas ao contexto atual e suas exigências por bons resultados e competitividade que, articuladas ao individualismo, põe sobre os pais a responsabilidade por gerir esse indivíduo produtivo desde a infância, fazendo do consumo de medicamentos um meio de responder a essas exigências. Tais aspectos evidenciam uma rede que ainda está em debate, em negociação e que pode ser seguida. Nesse sentido, consideramos importante seguir as práticas de psiquiatras, da indústria farmacêutica e da mídia na performação desse campo, assim como dos pais e da escola. Práticas que, postas em debate, podem ser diferentes, possibilitando a construção de outros futuros.

Recebido: 16/07/2020Aceite: 25/11/2020
Hubungan Antara Quality of Life dan Motivasi Belajar Siswa SMA/Sederajat di Jakarta Selama Masa Pandemi Covid-19
Authors: Tiarani Alma , Purwanti Margaretha , Aisyah Aireen Rhammy Kinara 
Published: December 2021

This study aimed to see the relationships between quality of life and learning motivation of high school students in Jakarta during the Covid-19 pandemic. The pandemic had a significant impact on society in Indonesia, including middle adolescence who are generally high school students. During the pandemic, several rules were put in place to break the chain of transmission of the coronavirus. Conditions that tend to be difficult to predict and dynamic during a pandemic were suspected to affect the quality of life and individual learning motivation.
This study uses a quantitative approach with a questionnaire as a data collection tool. The questionnaires used were the World Health Organization Quality of Life – BREF (WHOQOL-BREF) and the Motivated Strategies for Learning Questionnaire (MSLQ). Analysis of relationships between quality of life (QoL) and learning motivation by testing the correlation between aspects and components in the two variables. Participants in this study were high school students, currently undergoing PJJ, and domiciled in Jakarta. The participants used in the data analysis process were 168 people.
The results showed that there was a positive relationship between aspects of quality of life and components of learning motivation (rs = 0.189 – 0.363, p < .05, two-tailed). However, there is no relationship between aspects of quality of life and one component of learning motivation, namely the affective component (rs = -0.069 – 0.133, p > .05, two-tailed). The relationship between quality of life and learning motivation shows the significant role of the environment. It is expected that high school students, parents, teachers, and schools always establish communication and work together so that students have a quality of life and optimal learning motivation during the pandemic.
PENGARUH TINGKAT INFLASI DAN NILAI TUKAR (KURS) RUPIAH TERHADAP INDEKS SAHAM SYARIAH INDONESIA (ISSI)
Authors: Kamal Mustafa , Kasmawati  , Rodi  , Thamrin Husni , Iskandar  
Published: December 2021

Penelitian ini bertujuan untuk mengetahui pengaruh inflasi dan nilai tukar (kurs) rupiah secara parsial dan simultan terhadap Indeks Saham Syariah Indonesia (ISSI). Dilihat dari pergerakan ISSI yang mengalami perkembangan signifikan tentu hal tersebut dipengaruhi oleh beberapa variabel makroekonomi seperti pertumbuhan PDB, inflasi, dan nilai tukar. Metode analisis penelitian ini menggunakan metode analisis deskriptif, uji asumsi klasik, analisis regresi berganda, uji F (Uji Simultan), uji t (Uji Parsial), koefisien korelasi, dan koefisien determinasi dengan menggunakan bantuan software SPSS 25. Berdasarkan hasil uji secara simultan (Uji F) variabel inflasi (X1) dan nilai tukar (Kurs) Rupiah (X2) berpengaruh signifikan terhadap Indeks Saham Syariah Indonesia (ISSI). Hasil uji secara parsial (Uji t) variabel nilai tukar (Kurs) Rupiah berpengaruh signifikan terhadap ISSI, sedangkan untuk variabel inflasi tidak berpengaruh signifikan terhadap Indeks Saham Syariah Indonesia (ISSI). Keeratan hubungan variabel independen (X) dengan variabel dependen (Y) tergolong sedang. Sedangkan kontribusi variabel inflasi (X1) dan kurs rupiah (X2) terhadap ISSI (Y) sebesar 23,7% sedangkan sisanya 76,3% dipengaruhi oleh variabel yang tidak termasuk dalam penelitian ini.
Mathematical modelling for the functioning of the p53 signaling pathway following DNA damage. I. The model of activation of the p53-Mdm2-Wip1 system
Authors: Воропаева Ольга Фалалеевна , Гаврилова Ксения Сергеевна 
Published: December 2021

Работа посвящена численному исследованию известной математической модели динамики системы p53-Mdm2-Wip1 при различных воздействиях, приводящих к повреждениям ДНК. Главное внимание уделено ранее не рассматривавшимся методическим аспектам - оценке чувствительности модели, качественному анализу свойств решения в биологически адекватном диапазоне значений параметров, анализу применимости модели к описанию критических состояний системы, связанных с известными дегенеративными заболеваниями. Показано, что простейшая модификация исходной модели делает ее существенно более эффективным инструментом для численного анализа широкого диапазона состояний системы p53-Mdm2-Wip1
In the context of the survival and death of cells with DNA damage, a special role is assigned to the p53 protein. The management of p53 and its inhibitors can provide a protective effect in a wide range of degenerative diseases, such as cancer, infarctions, and dementia. Therefore, there are increased requirements for mathematical models designed to study the mechanism of functioning of the p53 signaling pathway. Our work is devoted to the study of the properties of the well-known mathematical model of the dynamics of the p53-Mdm2-Wip1 system under various influences leading to DNA damage. A simple modification of the model is proposed. The main attention is paid to the analysis of the sensitivity and qualitative properties of solutions, as well as the validation of the model before and after its modification. In numerical experiments, it was found that within the framework of the accepted models, the stationary state of the p53-Mdm2-Wip1 system can be unstable to negligible changes in the initial conditions, so that the system can function under the same parameter values according to the bifurcation scenario with a doubling of the period. The mathematical conditions under which the multiplicity of solutions and complex dynamic modes were detected allow for a biological interpretation as a reflection of the variability in the response of the p53 protein pathway to the damage signal. The range of applicability of the models was compared using the example of a wellknown laboratory experiment, in which the most complete set of observed in vitro and in vivo states of the p53-Wip1 system was demonstrated when irradiating cancer cells with wild-type p53. It is shown that the simplest modification of the original model significantly expands the scope of its applicability, allows describing the transition from normal to critical states of the system associated with known degenerative diseases. Thus, the modified model is a more effective tool for numerical analysis of a wide range of states of the p53-Mdm2-Wip1 system
Approaches to discrete optimization problems with interval objective function
Authors: Пролубников Александр Вячеславович 
Published: December 2021

В работе дается обзор подходов к решению задач дискретной оптимизации с интервальной целевой функцией. Эти подходы рассматриваются в общем контексте исследований оптимизационных задач с неопределенностями в постановках. Приводятся варианты концепций оптимальности решений для задач дискретной оптимизации с интервальной целевой функцией - робастные решения, множества решений, оптимальных по Парето, слабые и сильные оптимальные решения, объединенные множества решений и др. Оценивается предпочтительность выбора той или иной концепции оптимальности при решении задач и отмечаются ограничения для применения использующих их подходов
Optimization problems with uncertainties in their input data have been investigated by many researchers in different directions. There are a lot of sources of the uncertainties in the input data for applied problems. Inaccurate measurements and variability of the parameters with time are some of such sources. The interval of possible values of uncertain parameter is the natural and the only possible way to represent the uncertainty for a wide share of applied problems. We consider discrete optimization problems with interval uncertainties in their objective functions. The purpose of the paper is to provide an overview of the investigations in this field. The overview is given in the overall context of the researches of optimization problems with uncertainties. We review the interval approaches for the discrete optimization problem with interval objective function. The approaches we consider operate with the interval values and are focused on obtaining possible solutions or certain sets of the solutions that are optimal according to some concepts of optimality that are used by the approaches. We consider the different concepts of optimality: robust solutions, the Pareto sets, weak and strong solutions, the united solution sets, the sets of possible approximate solutions that correspond to possible values of uncertain parameters. All the approaches we consider allow absence of information on probabilistic distribution on intervals of possible values of parameters, though some of them may use the information to evaluate the probabilities of possible solutions, the distribution on the interval of possible objective function values for the solutions, etc. We assess the possibilities and limitations of the considered approaches
CABARET scheme on moving grids for two-dimensional equations of gas dynamics and dynamic elasticity
Authors: Афанасьев Н.А. , Майоров П.А. 
Published: December 2021

Схема КАБАРЕ, являющаяся представителем семейства балансно-характеристических методов, широко используется при решении многих задач для систем дифференциальных уравнений гиперболического типа в эйлеровых переменных. Возрастающая актуальность задач взаимодействия деформируемых тел с потоками жидкости и газа требует адаптации этого метода на лагранжевы и смешанные эйлерово-лагранжевы переменные. Ранее схема КАБАРЕ была построена для одномерных уравнений газовой динамики в массовых лагранжевых переменных, а также для трехмерных уравнений динамической упругости. В первом случае построенную схему не удалось обобщить на многомерные задачи, а во втором — использовался необратимый по времени алгоритм передвижения сетки. В данной работе представлено обобщение метода КАБАРЕ на двумерные уравнения газовой динамики и динамической упругости в смешанных эйлерово-лагранжевых и лагранжевых переменных. Построенный метод является явным, легко масштабируемым и обладает свойством временн´ой обратимости. Метод тестируется на различных одномерных и двумерных задачах для обеих систем уравнений (соударение упругих тел, поперечные колебания упругой балки, движение свободной границы идеального газа).
The conservative-characteristic CABARET scheme is widely used in solving many problems for systems of differential equations of hyperbolic type in Euler variables. The increasing urgency of the problems of interaction of deformable bodies with liquid and gas flows requires the adaptation of this method to Lagrangian and arbitrary Lagrangian-Eulerian variables. Earlier, the CABARET scheme was constructed for one-dimensional equations of gas dynamics in mass Lagrangian variables, as well as for three-dimensional equations of dynamic elasticity. In the first case, the constructed scheme could not be generalized to multidimensional problems, and in the second, a time-irreversible grid movement algorithm was used. This paper presents a generalization of the CABARET method to two-dimensional equations of gas dynamics and dynamic elasticity in arbitrary Lagrangian-Eulerian and Lagrangian variables. The constructed method is explicit, easily scalable, and has the property of temporal reversibility. The method is tested on various one-dimensional and two-dimensional problems for both systems of equations (collision of elastic bodies, transverse vibrations of an elastic beam, motion of the free boundary of an ideal gas).
Реализация и производительность алгоритмов волновой томографии на вычислительных платформах SIMD CPU и GPU
Authors: Goncharsky A.V. , Romanov S.Y. , Seryozhnikov S.Y. 
Published: December 2021

This paper is concerned with implementation of wave tomography algorithms on modern SIMD CPU and GPU computing platforms. The field of wave tomography, which is currently under development, requires powerful computing resources. Main applications of wave tomography are medical imaging, nondestructive testing, seismic studies. Practical applications depend on computing hardware. Tomographic image reconstruction via wave tomography technique involves solving coefficient inverse problems for the wave equation. Such problems can be solved using iterative gradient-based methods, which rely on repeated numerical simulation of wave propagation process. In this study, finite-difference time-domain (FDTD) method is employed for wave simulation. This paper discusses software implementation of the algorithms and compares the performance of various computing devices: multi-core Intel and ARM-based CPUs, NVidia graphics processors.
В данной статье рассматривается реализация алгоритмов волновой томографии на современных вычислительных платформах SIMD CPU и GPU. Область волновой томографии, которая в настоящее время находится в стадии разработки, требует мощных вычислительных ресурсов. Основные области применения волновой томографии - это медицинская визуализация, неразрушающий контроль, сейсмические исследования. Практические приложения зависят от вычислительного оборудования. Восстановление томографического изображения методом волновой томографии включает решение коэффициентов обратной задачи для волнового уравнения. Такие проблемы могут быть решены с помощью итерационных градиентных методов, основанных на многократном численном моделировании процесса распространения волн. В этом исследовании для моделирования волн используется метод конечных разностей во временной области (FDTD). В статье обсуждается программная реализация алгоритмов и сравнивается производительность различных вычислительных устройств: многоядерных процессоров Intel и ARM, графических процессоров NVidia.
Kajian Ilmiah dan Deteksi Adiksi Internet dan Media Sosial di Indonesia Menggunakan XGBoost
Authors: Rismala Rita , Novamizanti Ledya , Ramadhani Kurniawan Nur , Rohmah Yuyun Siti , Parjuangan Sabam , Mahayana Dimitri 
Published: December 2021

Internet dan media sosial telah menjadi kebutuhan pokok manusia untuk mengakses informasi, terutama di masa pandemi COVID-19 saat ini. Hal ini penting untuk dikaji karena berdampak pada perilaku dan kesehatan psikologi seseorang. Berdasarkan sudut pandang filsafat sains, adiksi internet dan media sosial di Indonesia merupakan kenyataan saintifik karena telah memenuhi kriteria falsifikasi dan bisa diuji (testable) secara empiris. Hasil survei terhadap 1980 responden, diperoleh 25,56% responden teradiksi internet dan 20,2% teradiksi media sosial. Penelitian ini juga berhasil membangun model untuk mendeteksi adiksi internet dan media sosial menggunakan XGBoost, dengan F-Measure sebesar 69,23% untuk adiksi internet dan 67,66% untuk adiksi media sosial. Oleh karena itu, fenomena adiksi internet dan media sosial ini perlu mendapatkan perhatian khusus agar dapat diantisipasi sejak dini.
Strategi Konsep Gamifikasi dalam Aplikasi Teknologi Blockchain
Authors: Aini Qurotul , Rahardja Untung , Santoso Nuke Puji Lestari , Harahap Eka Purnama Purnama , Amelia Sindy 
Published: December 2021

Blockchain adalah tren baru yang meningkat pesat dari komunitas dan dunia usaha. Sebagai teknologi infrastruktur, dan dapat menemukan jalannya ke berbagai ranah seperti keuangan, medis, pasar digital, farmasi, dan lembaga pemerintah. Meskipun teknologi blockchain pada dasarnya dianggap sebagai fondasi Bitcoin, ia telah berkembang pesat melampaui mata uang virtual. Ini menjanjikan pembangunan kepercayaan, transparansi, dan integritas yang lebih baik tanpa pihak ketiga dan risiko penyensoran. Namun, keuntungan luar biasa ini ada harganya. Ekosistem blockchain penuh dengan masalah manusia-sentris dan ekonomis bagi para pesertanya, yang mengarah pada konsekuensi yang tidak diinginkan dalam jaringan yang terdesentralisasi. Rekayasa perangkat lunak gamified adalah bidang yang berkembang yang secara khusus memanfaatkan teknologi gamifikasi, penerapan mekanisme game dalam konteks non-game, untuk mengatasi masalah yang berhubungan dengan manusia. Saat ini tidak ada studi seputar blockchain yang telah diidentifikasi memiliki pandangan yang jelas tentang penelitian dan solusi yang ada untuk memanfaatkan gamifikasi dalam sistem blockchain yang muncul. Sebagai langkah pertama untuk mengatasi masalah ini, makalah ini membahas dan mengidentifikasi dua masalah utama berbasis manusia dalam aplikasi dan pengembangan mengimplementasi blockchain. Untuk masalah tersebut, dalam penelitian ini menggunakan metode literature review. Dengan adanya penelitian ini diharapkan gamifikasi dalam sistem blockchain dapat berjalan dengan maksimal dalam pengembangan pengimplementasinya
Pendekatan Baru untuk Merepresentasi Informasi di Bidang Pendidikan Menggunakan Kombinasi Ontologi
Authors: Kusuma Selvia Ferdiana , Sukya Fadelis , Heriadi Agustono 
Published: December 2021

Ontologi adalah sebuah konsep yang dirancang untuk merepresentasikan relasi antar informasi. Ontologi dapat digunakan untuk merepresentasikan informasi berbentuk hierarki maupun non hierarki. Namun, model ontologi yang ada saat ini pada umumnya selalu bersifat domain spesifik. Peran ahli sangat dominan ketika membuat ontologi yang bersifat domain spesifik. Kelengkapan informasi pada ontologi tergantung pada kemampuan ahli pada domain tersebut dan ahli di bidang teknologi informasi untuk merepresentasikan informasi ke dalam bentuk ontologi. Oleh sebab itu diperlukan model ontologi baru agar dapat menghasilkan ontologi yang tidak bersifat domain spesifik. Sehingga mempermudah proses representasi informasi ke dalam bentuk ontologi dan mengurangi peran ahli dalam proses pembuatan ontologi tersebut. Model ontologi baru yang diusulkan adalah kombinasi dari ontologi taksonomi dan ontologi kalimat. Informasi berbentuk hierarki akan direpresentasikan dalam bentuk ontologi taksonomi, sedangkan informasi non-hierarki akan direpresentasikan dalam bentuk ontologi kalimat. Berdasarkan uji coba yang telah dilakukan, diketahui bahwa kombinasi ontologi yang diusulkan dapat menghasilkan ontologi yang tidak bersifat domain spesifik, mempermudah proses pembangkitan ontologi, dan mengurangi peran ahli dalam pembuatan ontologi tersebut.