bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparedness for family caregiving prior to allogeneic hematopoietic stem cell transplantation
Authors: Winterling Jeanette , Kisch Annika , Alvariza Anette , Årestedt Kristofer , Bergkvist Karin 
Published: August 2021

AbstractObjectiveAllogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment associated with high morbidity and mortality. It is often necessary for family caregivers to become highly involved in the care, especially when patients return home after a long period of inpatient care. Family caregivers’ preparedness for the tasks and demands of the caregiving role prior to allo-HSCT might help them during this distressing time. The aim of this study was to explore whether demographic factors are associated with preparedness for caregiving prior to allo-HSCT and if such preparedness for caregiving is associated with caregiver outcomes in terms of caregiver burden, anxiety/depression, competence, self-efficacy, and general health among family caregivers.MethodThis correlational cross-sectional study included 86 family caregivers of patients to undergo allo-HSCT, who completed a self-administered questionnaire on preparedness, caregiver burden, anxiety/depression, competence, self-efficacy, and general health. Descriptive statistics and multiple regression models (linear and ordinal) were used to analyze the data.ResultsFamily caregivers with a higher education and those who were the patient's partner were significantly associated with a higher level of preparedness for caregiving, while gender and age were not significant. Higher preparedness was significantly associated with higher competence and self-efficacy and lower symptoms of depression, even after the model was adjusted for education, relationship to the patient, gender, and age but not for anxiety or caregiver burden. Higher levels of preparedness were also significantly associated with better general health.Significance of resultsA higher level of preparedness for caregiving prior to allo-HSCT was associated with better family caregiver outcomes. Assessing family caregivers prior to allo-HSCT to identify those with insufficient preparedness might enable the provision of individually tailored psycho-educational support to help them cope with their caregiving role and prevent potential negative consequences.
Institutions, ideas and economic change: some reflections on Geoffrey Hodgson's ‘Culture and Institutions’
Authors: Mokyr Joel 
Published: August 2021

AbstractProfessor Hodgson in his review of myA Culture of Growth(Princeton University Press, 2016) raises a number of important issues. One of them is the usefulness of the concept of a ‘market for ideas’ as an analytical tool in discussing the way cultural change affects economic change. Even though there is no price mechanism that clears the market, many basic components of the economic analysis of markets carry through and enriched by evolutionary concepts. A second question is the importance of cultural entrepreneurs, who play an important role in my book. It should be stressed that such ‘Vital Few’ were rarely indispensable, yet their influence on subsequent events may have imparted a direction on events and accelerated them. In any event, the success of such entrepreneurs was an indication of an intellectual environment sufficiently open to new ideas to be consistent with major new ideas such as the possibility and desirability of sustained economic progress.
Screening glyphosate-alternative weed control options in important perennial crops
Authors: Kanatas Panagiotis , Antonopoulos Nikolaos , Gazoulis Ioannis , Travlos Ilias S. 
Published: August 2021

AbstractThe current study aimed to screen glyphosate-alternative weed control methods in three perennial crops in Greece. Field trials were conducted and repeated (2018 to 2019 and 2019 to 2020) in a citrus orchard (Citrus clementina Hort. ex Tan), an olive grove (Olea europaea L.), and a vineyard (Vitis vinifera L.) under the randomized complete block design (nine treatments, four blocks). Glyphosate was applied in the citrus orchard (720 g ae ha−1), the olive grove (720 g ae ha−1), and the vineyard (1,800 g ae ha−1). Pelargonic acid (1,088 g ha−1; two times), barley (Hordeum vulgare L.) residues and white mustard (Sinapis alba L.) residues were evaluated in all sites. Mowing was evaluated in the citrus orchard (one time) and the vineyard (two times). Flazasulfuron (50 g ha−1), oxyfluorfen (144 g ha−1), and flumioxazin (150 g ha−1) were applied in the citrus orchard and the olive grove. Penoxsulam + florasulam (15 + 7.5 g ha−1) was also applied in the olive grove. Cycloxydim (200 g ha−1), quizalofop-p-ethyl (150 g ha−1) and propaquizafop (150 g ha−1) were applied in the vineyard. An untreated control was included in all sites. Flazasulfuron, oxyfluorfen, and flumioxazin resulted in similar normalized difference vegetation index (NDVI) and weed biomass to glyphosate in the citrus orchard in both years and evaluations. Pelargonic acid (two times) and mowing (one time) were effective on broadleaf weeds. Flazasulfuron and penoxsulam + florasulam were the most promising glyphosate-alternative weed control methods against hairy fleabane [Conyza bonariensis (L.) Cronquist] in the olive grove. Cover crop residues showed their suppressive ability as in the citrus orchard. All selective herbicides resulted in similar NDVI and johnsongrass [Sorghum halepense (L.) Pers.] dry weight values in the vineyard in both years. Negative and strong correlations were observed in all sites and years between crop yield and weed dry weight (R2 = 0.543 to 0.924).
Wave Transformation on a Fringing Reef System With Spur and Groove Structures
Authors: Acevedo‐Ramirez César A. , Stephenson W. , Wakes S. , Mariño‐Tapia I. 
Published: August 2021

AbstractSpurs and Grooves (SAG) are coral forereef structures with their main axis normal to the reef crest. The dimensions of SAG vary considerably on a global scale. Despite being common, there are relatively few studies that relate SAG morphology with wave transformation processes. Measurements of wave transformation are presented from Xahuayxol, Quintana Roo, Mexico, across a SAG zone with larger spurs than in previous studies. An array of pressure sensors and current meters sampling at high frequencies were deployed over 8 days. Our results show that SAG structures are more important for wave transformation than previously reported since a high rate of wave energy flux dissipation (up to 0.077 kW/m2) was found and the corresponding wave dissipation friction factor, fw (1.01), was four times higher as compared to other reefs. We also found that the wave dissipation rate over the spurs can be up to three times higher than the adjacent grooves (0.098 vs. 0.028 kW/m2). This study demonstrates that SAG plays a very important role in wave dissipation over coral reefs.
A Preliminary Study of Magnetosphere‐Ionosphere‐Thermosphere Coupling at Jupiter: Juno Multi‐Instrument Measurements and Modeling Tools
Authors: Wang Yuxian , Blanc Michel , Louis Corentin , Wang Chi , André Nicolas , Adriani Alberto , Allegrini Frederic , Blelly Pierre‐Louis , Bolton Scott , Bonfond Bertrand , Clark George , Dinelli Bianca Maria , Gérard Jean‐Claude , Gladstone Randy , Grodent Denis , Kotsiaros Stavros , Kurth William , Lamy Laurent , Louarn Philippe , Marchaudon Aurélie , Mauk Barry , Mura Alessandro , Tao Chihiro 
Published: August 2021

AbstractThe dynamics of the Jovian magnetosphere are controlled by the interplay of the planet's fast rotation, its main iogenic plasma source and its interaction with the solar wind. Magnetosphere‐Ionosphere‐Thermosphere (MIT) coupling processes controlling this interplay are significantly different from their Earth and Saturn counterparts. At the ionospheric level, they can be characterized by a set of key parameters: ionospheric conductances, electric currents and fields, exchanges of particles along field lines, Joule heating and particle energy deposition. From these parameters, one can determine (a) how magnetospheric currents close into the ionosphere, and (b) the net deposition/extraction of energy into/out of the upper atmosphere associated to MIT coupling. We present a new method combining Juno multi‐instrument data (MAG, JADE, JEDI, UVS, JIRAM and Waves) and modeling tools to estimate these key parameters along Juno's trajectories. We first apply this method to two southern hemisphere main auroral oval crossings to illustrate how the coupling parameters are derived. We then present a preliminary statistical analysis of the morphology and amplitudes of these key parameters for eight among the first nine southern perijoves. We aim to extend our method to more Juno orbits to progressively build a comprehensive view of Jovian MIT coupling at the level of the main auroral oval.
Effect of pelvic laparoscopic implantation of neuroprosthesis in spinal cord injured subjects: a 1-year prospective randomized controlled study
Authors: Kasch Helge , Løve Uffe Schou , Jønsson Anette Bach , Severinsen Kaare Eg , Possover Marc , Elmgreen Søren Bruno , Forman Axel 
Published: August 2021

Abstract
Study design
1-year prospective RCT.

Objective
Examine the effect of implantable pulse generator and low-frequency stimulation of the pelvic nerves using laparoscopic implantation of neuroprosthesis (LION) compared with neuromuscular electrical stimulation (NMES) in SCI.

Methods
Inclusion criteria: traumatic spinal cord injury (SCI), age 18–55 years, neurological level-of-injury Th4–L1, time-since-injury >1 year, and AIS-grades A–B. Participants were randomized to (A) LION procedure or (B) control group receiving NMES. Primary outcome measure: Walking Index for Spinal Cord Injury (WISCI-II), which is a SCI specific outcome measure assessing ability to ambulate. Secondary outcome measures: Spinal Cord Independence Measure III (SCIM III), Patient Global Impression of Change (PGIC), Penn Spasm Frequency Scale (PSFS), severity of spasticity measured by Numeric Rating Scale (NRS-11); International Spinal Cord Injury data sets-Quality of Life Basic Data Set (QoLBDS), and Brief Pain Inventory (BPI).

Results
Seventeen SCI individuals, AIS grade A, neurological level ranging from Th4–L1, were randomized to the study. One individual was excluded prior to intervention. Eight participants (7 males) with a mean age (SD) of 35.5 (12.4) years were allocated to the LION procedure, 8 participants (7 males) with age of 38.8 (15.1) years were allocated to NMES. Significantly, 5 LION group participants gained 1 point on the WISCI II scale, (p < 0.013; Fisher´s exact test). WISCI II scale score did not change in controls. No significant changes were observed in the secondary outcome measures.

Conclusion
The LION procedure is a promising new treatment for individuals with SCI with significant one-year improvement in walking ability.
Genetic engineering of marine cyanophages reveals integration but not lysogeny in T7-like cyanophages
Authors: Shitrit Dror , Hackl Thomas , Laurenceau Raphael , Raho Nicolas , Carlson Michael C G , Sabehi Gazalah , Schwartz Daniel A , Chisholm Sallie W , Lindell Debbie 
Published: August 2021

Abstract
Marine cyanobacteria of the genera Synechococcus and Prochlorococcus are the most abundant photosynthetic organisms on earth, spanning vast regions of the oceans and contributing significantly to global primary production. Their viruses (cyanophages) greatly influence cyanobacterial ecology and evolution. Although many cyanophage genomes have been sequenced, insight into the functional role of cyanophage genes is limited by the lack of a cyanophage genetic engineering system. Here, we describe a simple, generalizable method for genetic engineering of cyanophages from multiple families, that we named REEP for REcombination, Enrichment and PCR screening. This method enables direct investigation of key cyanophage genes, and its simplicity makes it adaptable to other ecologically relevant host-virus systems. T7-like cyanophages often carry integrase genes and attachment sites, yet exhibit lytic infection dynamics. Here, using REEP, we investigated their ability to integrate and maintain a lysogenic life cycle. We found that these cyanophages integrate into the host genome and that the integrase and attachment site are required for integration. However, stable lysogens did not form. The frequency of integration was found to be low in both lab cultures and the oceans. These findings suggest that T7-like cyanophage integration is transient and is not part of a classical lysogenic cycle.
Emergence and expansion of SARS-CoV-2 B.1.526 after identification in New York
Authors: Annavajhala Medini K. , Mohri Hiroshi , Wang Pengfei , Nair Manoj , Zucker Jason E. , Sheng Zizhang , Gomez-Simmonds Angela , Kelley Anne L. , Tagliavia Maya , Huang Yaoxing , Bedford Trevor , Ho David D. , Uhlemann Anne-Catrin 
Published: August 2021

AbstractSARS-CoV-2 infections have surged across the globe in recent months, concomitant with considerable viral evolution1–3. Extensive mutations in the spike protein may threaten the efficacy of vaccines and therapeutic monoclonal antibodies4. Two signature spike mutations of concern are E484K, which has a crucial role in the loss of neutralizing activity of antibodies, and N501Y, a driver of rapid worldwide transmission of the B.1.1.7 lineage. Here we report the emergence of the variant lineage B.1.526 (also known as the Iota variant5), which contains E484K, and its rise to dominance in New York City in early 2021. This variant is partially or completely resistant to two therapeutic monoclonal antibodies that are in clinical use and is less susceptible to neutralization by plasma from individuals who had recovered from SARS-CoV-2 infection or serum from vaccinated individuals, posing a modest antigenic challenge. The presence of the B.1.526 lineage has now been reported in all 50 states in the United States and in many other countries. B.1.526 rapidly replaced earlier lineages in New York, with an estimated transmission advantage of 35%. These transmission dynamics, together with the relative antibody resistance of its E484K sub-lineage, are likely to have contributed to the sharp rise and rapid spread of B.1.526. Although SARS-CoV-2 B.1.526 initially outpaced B.1.1.7 in the region, its growth subsequently slowed concurrently with the rise of B.1.1.7 and ensuing variants.
Hourly potential evapotranspiration at 0.1° resolution for the global land surface from 1981-present
Authors: Singer Michael Bliss , Asfaw Dagmawi Teklu , Rosolem Rafael , Cuthbert Mark O. , Miralles Diego G. , MacLeod David , Quichimbo Edisson Andres , Michaelides Katerina 
Published: August 2021

AbstractChallenges exist for assessing the impacts of climate and climate change on the hydrological cycle on local and regional scales, and in turn on water resources, food, energy, and natural hazards. Potential evapotranspiration (PET) represents atmospheric demand for water, which is required at high spatial and temporal resolutions to compute actual evapotranspiration and thus close the water balance near the land surface for many such applications, but there are currently no available high-resolution datasets of PET. Here we develop an hourly PET dataset (hPET) for the global land surface at 0.1° spatial resolution, based on output from the recently developed ERA5-Land reanalysis dataset, over the period 1981 to present. We show how hPET compares to other available global PET datasets, over common spatiotemporal resolutions and time frames, with respect to spatial patterns of climatology and seasonal variations for selected humid and arid locations across the globe. We provide the data for users to employ for multiple applications to explore diurnal and seasonal variations in evaporative demand for water.
Highly efficient removal of Sb(V) from water by franklinite-containing nano-FeZn composites
Authors: Wu Huiqing , Wu Qingping , Zhang Jumei , Gu Qihui , Guo Weipeng , Rong Shun , Zhang Yongxiong , Wei Xianhu , Wei Lei , Sun Ming , Li Aimei , Jing Xinhui 
Published: August 2021

AbstractThe existence of toxic and carcinogenic pentavalent antimony in water is a great safety problem. In order to remove antimony(V) from water, the purpose of this study was to prepare a novel graphene nano iron zinc (rGO/NZV-FeZn) photocatalyst via hydrothermal method followed by ultrasonication. Herein, weakly magnetic nano-Fe–Zn materials (NZV-FeZn, GACSP/NZV-FeZn, and rGO/NZV-FeZn) capable of rapid and efficient Sb(V) adsorption from water were prepared and characterised. In particular, rGO/NZV-FeZn was shown to comprise franklinite, Fe0, and graphite. Adsorption data were fitted by a quasi-second-order kinetic equation and Langmuir model, revealing that among these materials, NZV-FeZn exhibited the best Sb removal performance (543.9 mgSb gNZV-FeZn−1, R2 = 0.951). In a practical decontamination test, Sb removal efficiency of 99.38% was obtained for a reaction column filled with 3.5 g of rGO/NZV-FeZn. Column regenerability was tested at an initial concentration of 0.8111 mgSb L−1, and the treated water obtained after five consecutive runs complied with the GB5749-2006 requirement for Sb. rGO/NZV-FeZn was suggested to remove Sb(V) through adsorption-photocatalytic reduction and flocculation sedimentation mechanisms and, in view of its high cost performance, stability, and upscalable synthesis, was concluded to hold great promise for source water and wastewater treatment.
Assessment of genetic diversity and variety identification based on developed retrotransposon-based insertion polymorphism (RBIP) markers in sweet potato (Ipomoea batatas (L.) Lam.)
Authors: Meng Yusha , Su Wenjin , Ma Yanping , Liu Lei , Gu Xingguo , Wu Dianxing , Shu Xiaoli , Lai Qixian , Tang Yong , Wu Liehong , Wang Yin 
Published: August 2021

AbstractSweet potato, a dicotyledonous and perennial plant, is the third tuber/root crop species behind potato and cassava in terms of production. Long terminal repeat (LTR) retrotransposons are highly abundant in sweet potato, contributing to genetic diversity. Retrotransposon-based insertion polymorphism (RBIP) is a high-throughput marker system to study the genetic diversity of plant species. To date, there have been no transposon marker-based genetic diversity analyses of sweet potato. Here, we reported a structure-based analysis of the sweet potato genome, a total of 21555 LTR retrotransposons, which belonged to the main LTR-retrotransposon subfamilies Ty3-gypsy and Ty1-copia were identified. After searching and selecting using Hidden Markov Models (HMMs), 1616 LTR retrotransposon sequences containing at least two models were screened. A total of 48 RBIP primers were synthesized based on the high copy numbers of conserved LTR sequences. Fifty-six amplicons with an average polymorphism of 91.07% were generated in 105 sweet potato germplasm resources based on RBIP markers. A Unweighted Pair Group Method with Arithmatic Mean (UPGMA) dendrogram, a model-based genetic structure and principal component analysis divided the sweet potato germplasms into 3 groups containing 8, 53, and 44 germplasms. All the three analyses produced significant groupwise consensus. However, almost all the germplasms contained only one primary locus. The analysis of molecular variance (AMOVA) among the groups indicated higher intergroup genetic variation (53%) than intrapopulation genetic variation. In addition, long-term self-retention may cause some germplasm resources to exhibit variable segregation. These results suggest that these sweet potato germplasms are not well evolutionarily diversified, although geographic speciation could have occurred at a limited level. This study highlights the utility of RBIP markers for determining the intraspecies variability of sweet potato and have the potential to be used as core primer pairs for variety identification, genetic diversity assessment and linkage map construction. The results could provide a good theoretical reference and guidance for germplasm research and breeding.
Non-lethal effects of entomopathogenic nematode infection
Authors: Filgueiras Camila C. , Willett Denis S. 
Published: August 2021

AbstractEntomopathogenic nematodes are typically considered lethal parasites of insect hosts. Indeed they are employed as such for biological control of insect pests. The effects of exposure to entomopathogenic nematodes are not strictly limited to mortality, however. Here we explore non-lethal effects of exposure to entomopathogenic nematodes by introducing the relatively non-susceptible pupal stage of Delia antiqua to thirteen different strains. We specifically chose to inoculate the pupal stage because it tends to be more resistant to infection, yet resides in the soil where it could come into contact with EPN biological control agents. We find that there is no significant mortality at the pupal stage, but that there are a host of strain-dependent non-lethal effects during and after the transition to adulthood including altered developmental times and changes in risk of death compared to controls. We also find that exposure to specific strains can reduce risk of mortality. These results emphasize the strain-dependent nature of entomopathogenic nematode infection and highlight the positive and negative ramifications for non-lethal effects for biological control of insect pests. Our work emphasizes the need for strain-specific screening of biological control agents before wide-spread adoption.
Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth
Authors: Huusko Johanna M. , Tiensuu Heli , Haapalainen Antti M. , Pasanen Anu , Tissarinen Pinja , Karjalainen Minna K. , Zhang Ge , Christensen Kaare , Ryckman Kelli K. , Jacobsson Bo , Murray Jeffrey C. , Kingsmore Stephen F. , Hallman Mikko , Muglia Louis J. , Rämet Mika 
Published: August 2021

AbstractHeat shock proteins are involved in the response to stress including activation of the immune response. Elevated circulating heat shock proteins are associated with spontaneous preterm birth (SPTB). Intracellular heat shock proteins act as multifunctional molecular chaperones that regulate activity of nuclear hormone receptors. Since SPTB has a significant genetic predisposition, our objective was to identify genetic and transcriptomic evidence of heat shock proteins and nuclear hormone receptors that may affect risk for SPTB. We investigated all 97 genes encoding members of the heat shock protein families and all 49 genes encoding nuclear hormone receptors for their potential role in SPTB susceptibility. We used multiple genetic and genomic datasets including genome-wide association studies (GWASs), whole-exome sequencing (WES), and placental transcriptomics to identify SPTB predisposing factors from the mother, infant, and placenta. There were multiple associations of heat shock protein and nuclear hormone receptor genes with SPTB. Several orthogonal datasets supported roles for SEC63, HSPA1L, SACS, RORA, and AR in susceptibility to SPTB. We propose that suppression of specific heat shock proteins promotes maintenance of pregnancy, whereas activation of specific heat shock protein mediated signaling may disturb maternal–fetal tolerance and promote labor.