bluuebunny/crossref_metadata_2025_split huggingface dataset:
Micropulse Laser Trabeculoplasty On Glaucoma Patients: Average 35 Months Follow-Up Results
Authors: Yang Yuting , Huang Xinting , Liao Sheng , Zhang Feng , Shi Jingming , Duan Xuanchu , Liu Ke 
Published: September 2021

Abstract
Background: Glaucoma is a group of eye diseases that can damage the optic nerve and cause vision loss. A novel technology micropulse laser trabecular plasty (MLT) can use duty-circle subvisible laser pulses to treat glaucoma. The aim of this study is to evaluate the efficacy of 360° MLT to alleviate intraocular pressure (IOP) in patients with glaucoma.Methods: This was a single-center prospective study on patients treated with 360° MLT using a Diode True-Yellow 577-nm Laser with MicroPulse technology. All the patients were recruited from the Department of Ophthalmology. Follow-up visits were carried out at 1 day, 1 week, 1 month, 3 months, 6 months, 18 months, and 36 months after the procedure. Best-corrected visual acuity (BCVA), Intraocular pressure (IOP), and vertical cup-to-disc ratio (C/D ratio) were measured during the follow-up. Repeated-measures analysis of variance (ANOVA) and Kaplan–Meier analysis were performed to evaluate the outcomes.Results: A total of 39 eyes from 26 patients were included in this study (10 men/15 women). The average age of patients was 41.47±14.39 years old, and the baseline IOP was 21.13 ± 7.75 mmHg. MLT significantly reduced the IOP at 1 day (range 15.61–19.01, P=0.0218), 3 months (range 16.47–19.22, P=0.0390), and 6 months (range 15.38–18.56, P=0.0332) compared with the baseline. However, by the end of the study, only 21.88% of patients demonstrated a ≥ 20% IOP reduction, while seven eyes needed further laser or surgical treatment. Conclusions: Micropulse laser trabeculoplasty could reduce IOP in patients with glaucoma or ocular hypertension for a short period, but its lowering efficiency was limited up to 6 months of the follow-up period.
Dose tranexamic acid reduce blood loss associated with simultaneous bilateral distal tibial tubercle-high tibial osteotomy?
Authors: Wang Zhimeng , Huang Qiang , Liu Lu , Lu Yao , Zhang Congming , Ma Teng , Li Zhong , Wang Qian , Xue Hanzhong , Zhang Kun 
Published: September 2021

Abstract
Background
Simultaneous bilateral distal tibial tubercle high tibial osteotomy (SBDTT-HTO) can result in increased blood loss. The aim of this study is to evaluate the actual hemostatic effect of different tranexamic acid (TXA) treatment regimen in SBDTT-HTO.
Methods
We conducted a retrospective case–control study including 54 patients who underwent SBDTT-HTO. The single-dose group (n = 18) received 1 g of intravenous TXA 15–30 min before surgery, the two-dose group (n = 18) received an additional 1 g of intravenous TXA 6 h after surgery, and the multiple-dose group (n = 18) received an additional 1 g intravenous TXA per-day until discharge. Blood loss, hemoglobin levels, occurrence of any adverse events,functional analysis, quality of life, and pain assessmentswere compared among the three groups.
Results
The total blood loss, hidden blood loss, drainage volumes, and haemoglobin level in the multiple-dose group all occupy a significant advantage.(p < 0.05). In addition, faster recovery and better quality of life were observed in patients belonging to the multiple-dose group then single-dose group.(p < 0.05).
Conclusions
Based on our results, for patients undergoing SBDTT-HTO, sequential intravenous TXA administration can effectively and safely reduce blood loss without increasing the risk of thromboembolism, with the advantage of accelerating recovery.
Facilitators and Barriers To The Integration of Integrated Community Case Management Into The Health System in Zambia: A Case Study of Kapiri Mposhi District
Authors: Riri Johnson Vonje , Silumbwe Adam , Mweemba Chris , Zulu Joseph Mumba 
Published: September 2021

Abstract
Background

Zambia adopted the Integrated Community Case Management of childhood illness (ICCM) strategy in May 2010, targeting populations in rural communities and hard-to-reach areas. However, evidence suggests that ICCM integration into local health systems has been suboptimal, particularly at the district level. This study sought to explore factors that shape ICCM integration into the district health system in Kapiri Mposhi district, Zambia.
Methods

Data were gathered through 19 key informant interviews with district health managers, ICCM supervisors, health facility managers, and district health co-operating partners. The study was conducted in Kapiri Mposhi district, Zambia. Interviews were translated and transcribed verbatim. Data were were analyzed using thematic analysis in NVivo 11(QSR International).
Results

Facilitators to intergration of ICCM into the health system consisted of community involvement and support for the program, active community case detection and timeliness of health services, the program was not considered a significant shift from other community-based health interventions, district leadership and ownership of the program, availability of national and district-level policies supporting ICCM and engagement of international co-operating partners. Program incompatibility with some socio-cultural and religious cotexts, stock-out of prerequisite drugs and supplies, staff reshuffle and redeployment, inadequate supervision of health facilities, and nonpayment of community health worker incentives inhibited intergration of ICCM into the health system.
Conclusion

The study findings highlight key faciliators and barriers that should be considered by policy-makers, district health managers, ICCM supervisors, health facility managers, and co-operating partners, in designing context-specific implementation strategies, to ensure full integration of ICCM into the health system.
The protects of deep sea water against photoaging of HaCaT keratinocyte induced by UVB via suppression MMPs and MAPKs/NF-κB signaling pathway
Authors: Ma Xiaolei , Duan Duomo , Xie Baolong , Wang Xunliang 
Published: September 2021

Abstract
Ultraviolet radiation destroys skin through several harmful effects, like inducing reactive oxygen species, inflammatory response, and collagen degradation. In this study we researched the impact of deep seawater (DSW) on the photoaging of HaCaT keratinocytes induced by ultraviolet B (UVB). DSW can inhibit epidermal hyperplasia and collagen degradation, increase skin moisture and hydroxyproline content, thereby improving the macro and histopathological damage of skin under UVB irradiation. Besides, DSW can inhibit UVB-induced oxidative stress (OS), improve antioxidant enzyme activity and inhibit the cellular signal transduction pathway of inflammatory response. Results showed DSW curbed the UVB irradiated levels of reactive oxygen species, superoxide dismutase (SOD), oxidative enzyme, glutathione peroxidase (GSH-Px), proinflammatory cytokines (TNF-α, IL-6). DSW prevented UVB-induced photoaging by suppressing collagen disorientation and expression of MMPs induced by UVB. Moreover, Western blot analyses exhibited that DSW significantly lessened the protein levels of phosphorylated SAPK/JNK kinase, phosphorylated ERK1/2 kinase, and phosphorylated p38 kinase. Similarly, UVB induced nuclear translocation of nuclear factor kappa-B were diminished by treatment of DSW. Therefore, DSW may lessen skin OS and inflammatory response under UVB irradiation. These data suggest that DSW can be used as a potentially effective skin care and dietary supplement for attenuating UVB-induced premature skin aging.
Oral susceptibility of aedine and culicine mosquitoes (Diptera: Culicidae) to Batai orthobunyavirus
Authors: Hernandez-Triana Luis Miguel , Folly Arran , Barrero Elsa , Lumley Sarah , de Marco Maria del Mar Fernández , Sewgobind Sanam , McElhinney Lorraine M. , Fooks Anthony R. , Johnson Nicholas 
Published: September 2021

Abstract
Background

A number of zoonotic mosquito-borne viruses have emerged in Europe in recent decades. Batai virus (BATV), orthobunyavirus, is one example having been detected in mosquitoes and livestock. We conducted vector competency studies on three mosquito species at a low temperature to assess whether Aedes and Culex mosquito species are susceptible to infection with BATV.
Methods

Colonised lines of Aedes aegypti and Culex pipiens, and a wild-caught species, Aedes detritus, were orally inoculated with BATV strain 53.2, originally isolated from mosquitoes trapped in Germany in 2009. Groups of blood-fed female mosquitoes were maintained at 20oC for seven or fourteen days. Individual mosquitoes were screened for the presence of BATV in body, leg and saliva samples for evidence of infection, dissemination and transmission, respectively. Batai virus RNA was detected by RT-PCR and positive results confirmed by virus isolation in Vero cells.
Results

Aedes detritus was highly susceptible to BATV with infection prevalence at or above 80% at both time points. Disseminated infections were recorded in 30.7–41.6% of Ae. detritus and evidence for virus transmission with BATV detected in saliva samples (n = 1, dpi = 14) was observed. Lower rates of infection for Ae. aegypti and Cx. pipiens with no evidence for virus dissemination or transmission at either time point.
Conclusions

This study shows Ae. detritus may be a competent vector for BATV at 20oC, whereas Ae. aegypti and Cx. pipiens were not competent. Critically, the extrinsic incubation period appears to be ≤ 7 days for Ae. detritus, which may increase the onward transmissibility potential of BATV in these populations.
Targeted genome-wide SNP genotyping in feral horses using non-invasive fecal swabs
Authors: Gavriliuc Stefan , Reza Salman , Jeong Chanwoori , Getachew Fitsum , McLoughlin Philip Dunstan , Poissant Jocelyn 
Published: September 2021

Abstract
The development of high-throughput sequencing has prompted a transition in wildlife genetics from using microsatellites toward sets of Single Nucleotide Polymorphisms (SNPs). However, genotyping large numbers of targeted SNPs using non-invasive samples remains challenging due to relatively large DNA input requirements. Recently, target enrichment has emerged as a promising approach requiring little template DNA. We assessed the efficacy of Tecan Genomics’ Allegro Targeted Genotyping (ATG) for generating genome-wide SNP data in feral horses using DNA isolated from fecal swabs. Total and host-specific DNA were quantified for 989 samples collected as part of a long-term individual-based study of feral horses on Sable Island, Nova Scotia, Canada, using dsDNA fluorescence and a host-specific qPCR assay, respectively. Forty-eight samples representing 44 individuals containing at least 10ng of host DNA (ATG’s recommended minimum input) were genotyped using a custom multiplex panel targeting 279 SNPs. Genotyping accuracy and consistency were assessed by contrasting ATG genotypes with those obtained from the same individuals with SNP microarrays, and from multiple samples from the same horse, respectively. 62% of swabs yielded the minimum recommended amount of host DNA for ATG. Ignoring samples that failed to amplify, ATG recovered an average of 86.7% targeted sites per sample, while genotype concordance between ATG and SNP microarrays was 98.5%. The repeatability of genotypes from the same individual approached unity with an average of 99.9%. This study demonstrates the suitability of ATG for genome-wide, non-invasive targeted SNP genotyping, and will facilitate further ecological and conservation genetics research in equids and related species.
Thermal and Mechanical Stabilities of Core-shell Microparticles Containing a Liquid Core
Authors: Nguyen Nam-Trung , Nguyen Nam-Trung , Nguyen Nam-Trung , Nguyen Nam-Trung 
Published: September 2021

Abstract

Thorough understanding of the behaviour of core-shell microparticles with a liquid core is essential for determining their performance in applications under different operation conditions. This paper reports the behaviour of core-shell particles with a liquid core under thermal and mechanical loads. First, we formulated an analytical model for the heating process of a core-shell microparticle with a liquid core. Next, we utilised an axisymmetric model of an elastic spherical shell upon compression to describe the deformation of a core-shell microparticle. Finally, we conducted experiments to validate these models. Both thermal and mechanical models agree well with the experimental data. The maximum temperature a core-shell microparticle can withstand depends on the liquid, the geometry, and the material of the shell. The critical compression force before rupture of a core-shell microparticle depends on the Poisson’s ratio of the shell material and the shell thickness relative to the outer shell radius. The rupture force and rupture temperature increase with increasing shell thickness.
Lexibank: A public repository of standardized wordlists with computed phonological and lexical features
Authors: List Johann-Mattis , Forkel Robert , Greenhill Simon J. , Rzymski Christoph , Englisch Johannes , Gray Russell D. 
Published: September 2021

Abstract

The past decades have seen substantial growth in digital data on the world's languages. At the same time, the demand for cross-linguistic datasets has been increasing, as witnessed by numerous studies devoted to diverse questions on human prehistory, cultural evolution, and human cognition. Unfortunately, the majority of published datasets lack standardization which makes their comparison difficult. Here, we present the first step to increase the comparability of cross-linguistic lexical data. We have designed workflows for the computer-assisted lifting of datasets to Cross-Linguistic Data Formats, a collection of standards that increase the FAIRness of linguistic data. We test the Lexibank workflow on a collection of 100 lexical datasets from which we derive an aggregated database of wordlists in unified phonetic transcriptions covering more than 2000 language varieties. We illustrate the benefits of our approach by showing how phonological and lexical features can be automatically inferred, complementing and expanding existing cross-linguistic datasets.
Genetic algorithm application for electrodynamic transducer model identification
Authors: Volkov Denys , Zubkov Artem , Didkovskyi Vitalii 
Published: September 2021

Research object: the adaptation and application of the genetic algorithm for electrodynamic transducer model parameters identification.
Investigated problem: to formulate loudspeaker identification task as an optimization problem, adapt it to the genetic algorithm framework and compare obtained results with classical identification method using added mass.
Main scientific results: the complete genetic algorithm loudspeaker identification procedure is presented, including:
– data acquisition scheme, where the directly measured values for the algorithm application are: voltage at loudspeaker terminals, current through the voice coil and displacement of the moving part
– selection of an appropriate set of genes of an individual
– derivation of the fitness function for assessing the quality of the identified parameters, which can also be used to identify other types of electroacoustic transducers
Also, the advantages of this method in comparison with the classical method of identification using added mass are considered, that are its versatility and ability to quickly configure and adapt for research and experimentation with different loudspeaker models and different types of transducers used in acoustics.
Area of practical use of the research results: the proposed genetic loudspeaker model identification scheme can be directly applied on practice to speed up research and development tasks in electroacoustics and other related fields that require frequent experimentation with different types of transducer models.
Innovative technological product: genetic algorithm based loudspeaker identification scheme that can be applied to identify various model of electrodynamic transducers.
Scope of application of the innovative technological product: electroacoustics, loudspeaker design, audio systems
Efficiency determination of methods for eliminating the polarization layer in the process of membrane concentration of buttermilk
Authors: Omelchenko Oleksandr , Deynichenko Gregoriy , Huzenko Vasyl , Zolotukhina Inna , Dmytrevskyi Dmytro , Chervonyi Vitalii , Horielkov Dmytro , Melnik Olga , Korolenko Olha , Tsvirkun Liudmyla 
Published: September 2021

The object of research: the process of membrane concentration of buttermilk using methods of removing the polarizing layer on the membrane surface.
Investigated problem: determination of the effectiveness of methods for eliminating the polarization layer on the membrane surface during membrane concentration of buttermilk.
Main scientific results: The results of experimental studies on methods of removing the polarization layer to increase the productivity of ultrafiltration equipment in the process of membrane concentration of buttermilk are presented. Mathematical models are proposed based on the regression equation of a factorial experiment using the elimination of the polarization layer on the membrane to determine the rational operating parameters of the membrane concentration of buttermilk. These parameters were determined: pressure – 0.4 … 0.5 MPa, buttermilk temperature – 40 … 50 °С, speed of pulsating flows – 1.5 … 1.7 m/s, frequency of bubbling of raw materials – 0 , 10 … 0.15 min-1, bubbling pressure – 0.56 … 0.58 MPa. A comparative analysis of the application of the method of vibrational mixing and bubbling of separated non-fat dairy raw materials to eliminate the formation of a polarization layer on the surface of membranes in the process of membrane concentration is presented. Based on the obtained quantitative and qualitative characteristics of the ultrafiltration products, it can be seen that vibrational mixing and bubbling of the processed buttermilk equally intensify the process of membrane concentration of buttermilk.
The area of practical use of the research results: enterprises of the dairy industry of the food industry, engaged in waste-free processing of dairy raw materials and its by-products.
An innovative technological product: devices for reducing the polarization layer, allowing to increase the performance of membranes in the process of membrane concentration of buttermilk.
Scope of application of the innovative technological product: waste-free processing of dairy raw materials at dairies and dairy plants and other food industry enterprises.
The socio-economic impact of the Covid-19: a South African perspective on its impact on the socio-economic, inequality, security, and food systems
Authors: Yesufu Shaka 
Published: September 2021

The objects of this research are: first, to highlight some of the socio-economic impact, arising out of the government's strict lockdown rules due to the Covid-19 pandemic. Second, to explore the psychological effects of the new normal on citizens, arising out of the lockdown.
The author investigated the following problems: social problems, caused by restricted movements, increase interpersonal violence crimes, and economic problems due to job losses, emanating from several businesses closures.
The main results of the research are: very high number of death rates with over (78 000), succumbing to coronavirus in South Africa, high unemployment, threats of food scarcity, educational setbacks due to schools closure, economic inequality gap, more widely pronounced, and hospitals, put under severe pressure due high patients needs.
The area of practical use of the research is for all citizens, directly affected by the global pandemic. The research highlights the significance of the use of technology to inform and support lifelong learning using more e-learning platforms as an alternative for the old pedagogic delivery of lectures.
The innovative technological products, arising out of the lockdown, were several e-learning softwares introduced. Apps like ‘uber eats; Vromo; Open Table; and ChatFood were all introduced and made delivery of fast food to our homes relatively easy. Several e-learning products were made popular: Microsoft teams; Zoom; Skype; Canvas; Ariculate 360; 7 taps; Spayee and teachable.
The Scope of the innovative technology products were more pronounced in both the hospitality, catering industries, and educational institutions.
Trial using of ultrasonic cavitation in cottonization processes of hemp fibers
Authors: Hych Olha , Zakora Oksana , Rastorhuieva Mariia , Zilinskyi Andrii 
Published: September 2021

The object of research: ultrasonic processing technology of textile materials.
Investigated problem: increasing the degree of splitting of complex hemp fibers due to the effect of the mechanism of ultrasonic cavitation on them.
The main scientific results: The article shows the potential of textile production to ensure the environmental friendliness of textile products, and the development and implementation of new eco-technologies of physical and mechanical cottonization of hemp fiber is important in this. Analysis of existing methods of cottonization and structural features of hemp fibers has led to the conclusion that the destruction of cellulose satellites in complex fiber can be considered as a process of purification from impurities, since the technologies for purification of substances in the aquatic environment by ultrasound now are widely used. Therefore the process of cottonization of hemp by technology of ultrasonic treatment was used in this investigation for the first time. The basic principle effect on the textile material what placed in the liquid are the hydroacoustic effects formed by the collapse of cavitation bubbles in the contact zone "liquid-material". Experimental studies of the geometric characteristics of the obtained hemp cottonine were carried out, and the effectiveness of the effect of ultrasonic vibrations on the change of the structure of hemp fiber was confirmed. Due to the removal of inlaid substances under the action of cavitation, the complex fibers of hemp were split, as a result of which the range of variation and the absolute value of their length and linear density were decreased.
The scope of practical use of the research results: textile enterprises of deep processing of bast raw materials into technical and household yarns.
Innovation technological product: technology of ultrasonic cottonization of hemp fibers.
The scope of using the innovation technological product: manufacturing of textile hemp products for general use.
Urban stormwater nutrient and metal removal in small-scale green infrastructure: exploring engineered plant biofilter media optimisation
Authors: Jacklin D. M. , Brink I. C. , Jacobs S. M. 
Published: September 2021

Abstract
The present study evaluated engineered media for plant biofilter optimisation in an unvegetated column experiment to assess the performance of loamy sand, perlite, vermiculite, zeolite and attapulgite media under stormwater conditions enriched with varying nutrients and metals reflecting urban pollutant loads. Sixty columns, 30 unvegetated and 30 Juncus effusus vegetated, were used to test: pollutant removal, infiltration rate, particulate discharge, effluent clarity and plant functional response, over six sampling rounds. All engineered media outperformed conventional loamy sand across criteria, with engineered attapulgite consistently among the best performers. No reportable difference existed in vegetation exposed to different material combinations. For all media, the results show a net removal of NH3-N, PO43−-P, Cd, Cu, Pb and Zn and an increase of NO3−-N, emphasizing the importance of vegetation in biofilters. Growth media supporting increased rate of infiltration whilst maintaining effective remediation performance offers the potential for reducing the area required by biofilters, currently recommended at 2% of its catchment area, encouraging the use of small-scale green infrastructure in the urban area. Further research is required to assess the carrying capacity of engineered media in laboratory and field settings, particularly during seasonal change, gauging the substrate's potential moisture availability for root uptake.