bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole-Genome and Transcriptome Sequencing Identified NOTCH2 and HES1 As Potential Markers of Response to Imatinib in Desmoid Tumor (Aggressive Fibromatosis): A Phase II Trial Study
Authors: Kwon Joonha , Lee Jun Hyeong , Lee Young Han , Lee Jeeyun , Ahn Jin-Hee , Kim Se Hyun , Kim Seung Hyun , Kim Tae Il , Yun Kum-Hee , Park Young Suk , Kim Jeong Eun , Lee Kyu Sang , Choi Jung Kyoon , Kim Hyo Song 
Published: October 2021

Abstract
Background: Desmoid tumor, also known as aggressive fibromatosis, is well-characterized by abnormal Wnt/β-catenin signaling. Various therapeutic options, including imatinib, are available to efficiently treat desmoid tumor. However, molecular mechanism of why imatinib works remains poorly understood. Here, we describe the potential roles of NOTCH2 and HES1 in association with clinical response to imatinib as in genome and transcriptome levels. Methods: We identified all somatic mutations in coding and non-coding regions via whole genome sequencing using desmoid tumor samples. To validate the genetic interaction with expression level in desmoid-tumor condition, we utilized large-scale Whole-genome sequencing (WGS) and transcriptome datasets from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project. RNA-sequencing was performed using prospective and retrospective cohort samples to evaluate the expressional relevance with clinical response. Results: Among 20 patients, 4 (20%) had a partial response and 14 (66.7%) had stable disease, 11 of which continued for ≥1 year. With gene-wise functional analyses, we detected significant correlation between recurrent NOTCH2 noncoding mutations and clinical response to imatinib. Based on PCAWG data analyses, NOTCH2 mutations affect its expression levels particularly in the presence of CTNNB1 missense mutations. By analyzing RNA-sequencing with additional desmoid tumor samples, we found that NOTCH2 expression was significantly correlated with HES1 expression. Interestingly, NOTCH2 had no statistical power to discriminate responders and non-responders. Instead, HES1 was differentially expressed with statistical significance between responders and non-responders Conclusions: Imatinib was effective and well tolerated for advanced desmoid tumor treatment. Our results show that HES1, regulated by NOTCH2, as an indicator of sensitivity to imatinib, which provides an important therapeutic consideration for desmoid tumor. Trial Registration: ClinicalTrials.gov, NCT02495519, Registered July 13, 2015- Retrospectively registered, https://www.clinicaltrials.gov/ct2/show/NCT02495519
Impact of Conservation Agriculture and Cropping System On Soil Organic Carbon and Its Fractions in Alluvial Soils of Eastern Gangetic Plains
Authors: S Rakesh , Sinha Abhas K , Gathala Mahesh Kumar , Menzies  , Dutta Sudarshan , Dalal Ram C , Mukhopadhyay Prabir , Chowdhury Apurba K , Bhattacharya Prateek M , Poddar Parthendu 
Published: October 2021

Abstract
Purpose

A conservation agriculture-based sustainable intensification (CASI) practices have been proposed as a potential alternative management strategy for achieving the food, water and energy security while sustaining the soil health and climate resilience. In this study, we evaluate the performance of CASI technologies under two cropping systems on carbon (C) dynamics in the soils of recent and old alluvial nature of West Bengal in Eastern Alluvial Ganga Plains.
Methods

The on-farm field study was undertaken for four years during 2014-15 to 2018-19 with an objective of long-term setup at Coochbehar and Malda districts, West Bengal (subtropical eastern India). The two cropping systems (rice-wheat, RW and rice-maize, RM) and two tillage options (zero tillage, ZT and conventional tillage, CT) were evaluated on multi-location at farmers’ field to see the impact on soil total organic carbon (TOC) and its fractions, stratification, and stocks.
Results

About 20% higher TOC concentration was observed in the old alluvial soils (Inceptisols of Malda district) as compared to recent alluvial soils (Entisols of Coochbehar district). TOC and its fractions significantly (p<0.05) improved under RM cropping system than that under RW. The ZT system enhanced the TOC and its fractions by 16.8 and 9.8 % over CT at 0–5 and 5–10 cm respectively. All the C fractions showed strong positive correlation (r= >0.85; p < 0.01) with TOC except POC.
Conclusions

Our research indicated that ZT system increased the C turnover rate in both soil types which was found more prominent in RM system.
Lead-Zinc Mine Tailings Valorization Through Fly Ash-Based Geopolymer for Building Material: Synthesis, Microstructure, and Mechanical Properties
Authors: BAH ALSENY , Ramos Andrea ORTIZ , Daolun Feng , Jin jie , Bah Alhassane , Li Feihu 
Published: October 2021

Abstract
Using geopolymerization to value mining wastes in order to meet construction demand is a sustainable and environmentally friendly strategy. Fly ash geopolymer materials have been developed to address environmental issues such as climate change caused by the emissions of CO2 from coal fly ash plants, mining, and cement industry into the atmosphere. The main objective of this study is to study the feasibility of using mine tailings to produce environmentally friendly building materials (so-called geopolymer products) with excellent mechanical strength through fly-based geopolymer technology. Fly ash (F.A.) and mine tailings (M.T.) were utilized as raw materials and gypsum (G.Y.) as additives. Sodium hydroxide (NaOH) at (5-10M) and sodium silicate (water glass) constituted the alkaline solution and were added separately to the mixture. The mechanical property and microstructure of the geopolymers were assessed by performing the Unconfined Compressive Strength (UCS), Scanning Electron Microscopy (SEM), X-ray diffractions (XRD), and Fourier transforms infrared (FTIR). A 24 MPa was achieved at 10M NaOH with 100% F.A. Besides, low UCS values were obtained with only M.T. as a binder. The SEM imaging analysis confirmed similar results showing that the geopolymer specimens cured with 100% of F.A. at 10M NaOH with a moderate amount of gypsum are denser than those prepared without gypsum at 5M. The findings revealed that F.A., MT, and gypsum, together with the alkali reagents, influenced the geopolymerisation process. These factors responded effectively to the microstructural performance(increasing density), resulting in increased unconfined compressive strength.
A scenario-based coupled SWAT-MODFLOW decision support system for advanced water resource management
Authors: Izady A. , Joodavi A. , Ansarian M. , Shafiei M. , Majidi M. , Davary K. , Ziaei A. N. , Ansari H. , Nikoo M. R. , Al-Maktoumi A. , Chen M. , Abdalla O. 
Published: October 2021

Abstract
Models provide invaluable visions to decision-makers for basin-scale management of water resources. However, decision-makers have difficulties in directly using these complex models. Water managers are primarily interested in user-friendly features allowing an integration of their judgments into the decision-making process, rather than applying detailed theories and methodologies. This knowledge gap between technical simulation models and policy-makers highlights the urgent need for developing an integrated water resource management decision support system (IWRM-DSS). This paper describes the main aspects of a new IWRM-DSS in which Microsoft Visual Studio under the C# language was employed to integrate the Microsoft SQL server as a database and ArcGIS Engine DLLs for pre/postdata processing for the SWAT and MODFLOW models. Two particular ‘module’ and ‘presentation’ shells are specifically designed for decision-makers to create four different scenarios, namely, ‘climatic’, ‘recharge’, ‘discharge’, and ‘coupled’ and to analyze the results. Decision-makers, without any detailed modeling knowledge and computer skills, can access the data and run models to test different management scenarios in an attractive graphical user interface. The IWRM-DSS, which was applied for the Neishaboor watershed, Iran, reveals that mean annual potential evapotranspiration increased to 8.2%, while runoff and recharge rates are reduced to 35 and 63%, which led to a decline of 13.5 m in mean groundwater level for the 13-year projected period.
Environmental flow assessment in the context of climate change: a case study in Southern Quebec (Canada)
Authors: Berthot Laureline , St-Hilaire André , Caissie Daniel , El-Jabi Nassir , Kirby Judith , Ouellet-Proulx Sébastien 
Published: October 2021

Abstract
Through a case study in Southern Quebec (Canada), the assessment of environmental flows in light of the effects of climate change is investigated. Currently, the 7Q2 flow metric (7-day average flow with a 2-year return period) is used for water abstraction management. Several flow metrics were calculated using flow time series simulated by a deterministic hydrological model (HYDROTEL) and climate change scenarios as inputs. Results were compared within homogeneous low flow regions defined using ascendant hierarchical clustering, for the 1990, 2020 and 2050 horizons and annual, summer and winter periods. The impact of each flow metric on the potential availability of physical habitat was analyzed using the wetted perimeter as a proxy. Results indicated that: (1) the increasing non-stationarity of simulated flow data sets over time will complicate the use of frequency analysis to calculate the 7Q2 flow metric; (2) summer low flow values are expected to be lower than winter low flows; and (3) flow-duration curve metrics like the LQ50 (median discharge value of the month with the lowest flow) may become relevant environmental flow metrics by 2050. Results question current water abstraction management tools and permit us to anticipate future local and regional issues during low flow periods.
Water poverty assessment based on the random forest algorithm: application to Gansu, Northwest China
Authors: Gao Xiang , Wang Ke , Lo Kevin , Wen Ruiyang , Huang Xingxing , Dang Qianwen 
Published: October 2021

Abstract
This study proposes a random forest algorithm to evaluate water poverty. It shows how the machine learning technique can be used to classify the degree of water poverty into five levels: very severe, severe, moderate, mild, and very mild. The strengths of the proposed random forest method include a high classification accuracy, good operational efficiency, and the ability to handle high-dimensional datasets. The success of the proposed method is empirically illustrated through a case study in Gansu, Northwest China. The analysis shows that from 2000 to 2017, the severity of water poverty in the study area declined. In 2000, most municipalities were classified as level 1 (very severe) or level 2 (severe). In 2017, level 1 water poverty disappeared, with most municipalities classified in as level 3 (moderate) and level 4 (mild). Spatially, there is a significant difference between the water poverty levels of the western, central, and eastern parts of Gansu, and the eastern part is affected by serious water poverty problems.
Preparation and application of embedded and immobilized Achromobacter sp. agent for effective removal of ammonia nitrogen from water
Authors: Xiao Yao , Huang Yongbing , Wu Weishan , Li Yao , Li Zhipeng , Li Yanzheng , Tang Dongmei 
Published: October 2021

Abstract
A novel wastewater-quality-improver, Sodium Alginate Embedded Microbe-treated Zeolite (SAEMZ), was proposed. The strains used are screened from black-odorous water and have high-efficiency NH4+-N degradation performance. The Gram-positive bacteria, belonging to Achromobacter sp., was determined through the screening and identification for this strain, whose removal rate of NH4+-N can reach 88.06%, to decrease the NH4+-N concentration from 61.83 mg/L to 7.80 mg/L, and its optimal growth conditions are pH 7–8, rotation speed 150–210 r/min, temperature 25–35 °C. The SAEMZ's removal effect on NH4+-N was considered in this research from aspects of reusability, storage stability, and the effects of dosage, coexisting ions, and wastewater's concentration. The increase of the SAEMZ's dosage effectively improved the NH4+-N removal rate; Ca2+ in the solution promoted the NH4+-N removal rate, while Mg2+ and Mn2+ inhibited it. Also, the NH4+-N removal rate improved slightly with Fe2+ concentration's increase and then decreased significantly; with the increase of the wastewater dilution factor, the NH4+-N removal rate showed an upward trend and with the increase of the SAEMZ's reuse times, it decreased. Therefore, recycle times should be controlled to less than 3 times in practical application; the SAEMZ still maintains its physiological stability, high mechanical strength, and good storage stability after being stored at 4 °C for 120 days.
Learning Outcomes of Immersive Technologies in Health Care Student Education: Systematic Review of the Literature
Authors: Ryan Grace V , Callaghan Shauna , Rafferty Anthony , Higgins Mary F , Mangina Eleni , McAuliffe Fionnuala 
Published: October 2021

Background
There is a lack of evidence in the literature regarding the learning outcomes of immersive technologies as educational tools for teaching university-level health care students.

Objective
The aim of this review is to assess the learning outcomes of immersive technologies compared with traditional learning modalities with regard to knowledge and the participants’ learning experience in medical, midwifery, and nursing preclinical university education.

Methods
A systematic review was conducted according to the Cochrane Collaboration guidelines. Randomized controlled trials comparing traditional learning methods with virtual, augmented, or mixed reality for the education of medicine, nursing, or midwifery students were evaluated. The identified studies were screened by 2 authors independently. Disagreements were discussed with a third reviewer. The quality of evidence was assessed using the Medical Education Research Study Quality Instrument (MERSQI). The review protocol was registered with PROSPERO (International Prospective Register of Systematic Reviews) in April 2020.

Results
Of 15,627 studies, 29 (0.19%) randomized controlled trials (N=2722 students) were included and evaluated using the MERSQI tool. Knowledge gain was found to be equal when immersive technologies were compared with traditional learning modalities; however, the learning experience increased with immersive technologies. The mean MERSQI score was 12.64 (SD 1.6), the median was 12.50, and the mode was 13.50. Immersive technology was predominantly used to teach clinical skills (15/29, 52%), and virtual reality (22/29, 76%) was the most commonly used form of immersive technology. Knowledge was the primary outcome in 97% (28/29) of studies. Approximately 66% (19/29) of studies used validated instruments and scales to assess secondary learning outcomes, including satisfaction, self-efficacy, engagement, and perceptions of the learning experience. Of the 29 studies, 19 (66%) included medical students (1706/2722, 62.67%), 8 (28%) included nursing students (727/2722, 26.71%), and 2 (7%) included both medical and nursing students (289/2722, 10.62%). There were no studies involving midwifery students. The studies were based on the following disciplines: anatomy, basic clinical skills and history-taking skills, neurology, respiratory medicine, acute medicine, dermatology, communication skills, internal medicine, and emergency medicine.

Conclusions
Virtual, augmented, and mixed reality play an important role in the education of preclinical medical and nursing university students. When compared with traditional educational modalities, the learning gain is equal with immersive technologies. Learning outcomes such as student satisfaction, self-efficacy, and engagement all increase with the use of immersive technology, suggesting that it is an optimal tool for education.
Intervention for a Digital, Cognitive, Multi-Domain Alzheimer Risk Velocity Study: Protocol for a Randomized Controlled Trial
Authors: Gray Michelle , Madero Erica N , Gills Joshua L , Paulson Sally , Jones Megan D , Campitelli Anthony , Myers Jennifer , Bott Nicholas T , Glenn Jordan M 
Published: October 2021

Background
In the United States, more than 6 million adults live with Alzheimer disease (AD) that affects 1 out of every 3 older adults. Although there is no cure for AD currently, lifestyle-based interventions aimed at slowing the rate of cognitive decline or delaying the onset of AD have shown promising results. However, most studies primarily focus on older adults (>55 years) and use in-person interventions.

Objective
The aim of this study is to determine the effects of a 2-year digital lifestyle intervention on AD risk among at-risk middle-aged and older adults (45-75 years) compared with a health education control.

Methods
The lifestyle intervention consists of a digitally delivered, personalized health coaching program that directly targets the modifiable risk factors for AD. The primary outcome measure is AD risk as determined by the Australian National University-Alzheimer Disease Risk Index; secondary outcome measures are functional fitness, blood biomarkers (inflammation, glucose, cholesterol, and triglycerides), and cognitive function (Repeatable Battery for the Assessment of Neuropsychological Status and Neurotrack Cognitive Battery). Screening commenced in January 2021 and was completed in June 2021.

Results
Baseline characteristics indicate no difference between the intervention and control groups for AD risk (mean −1.68, SD 7.31; P=.90).

Conclusions
The intervention in the Digital, Cognitive, Multi-domain Alzheimer Risk Velocity is uniquely designed to reduce the risk of AD through a web-based health coaching experience that addresses the modifiable lifestyle-based risk factors.

Trial Registration
ClinicalTrials.gov NCT04559789; https://clinicaltrials.gov/show/NCT04559789

International Registered Report Identifier (IRRID)
DERR1-10.2196/31841
«Tu sei acqua». Dialogo e dissolvenza tra Roni Horn e Anne Carson
Authors: Anedda Angioy Antonella 
Published: October 2021

Il titolo dell’intervento è una variazione sul titolo You are the Weather dell’artista Roni Horn, realizzato in Islanda: il viso di una giovane donna veniva fotografato durante diverse condizioni meteorologiche mentre si bagnava nelle sorgenti dell’isola. La ricerca di Horn sull’identità, sul suo comporsi e decomporsi, sulla meteorologia delle nostre emozioni trova un’interlocutrice nella scrittrice e poeta di origini canadesi Anne Carson.
Keywords: acqua, identità, conoscenza, dissoluzione, Anne Carson, Roni Horn.
Nota preliminar
Authors: López Guil Itzíar , González Vicente Juan Antonio 
Published: October 2021

Se presenta aquí, de forma somera, el contenido de las dos secciones que conforman este número 68 de Versants: el apartado monográfico conmemora el 80 aniversario de la muerte de Miguel Hernández y se dedica al estudio de las dimensiones metapoética y autorreferencial presentes en su obra. La sección de tema libre está integrada por un artículo del veterano Jon Kortázar sobre Harri eta Herri de Gabriel Aresti y otro de un grupo de investigadores noveles de la Universidad de Zúrich acerca de la autorreflexión en tres cuentos de Medardo Fraile.
Keywords: Miguel Hernández, autorreferencialidad, metapoesía, Harri eta Herri, Gabriel Aresti, Medardo Fraile.
UJI EFEK ANTELMINTIK INFUS BUNGA WIDURI (Calotropis gigantea) (L.) Dryand TERHADAP CACING HATI (Fasciola) SECARA IN VITRO
Authors: Pratama Iman Surya , Toyyibah Zurriatun , Tresnani Galuh 
Published: October 2021

Fasciolosis merupakan penyakit parasit yang dapat menyerang sapi dan manusia disebabkan oleh Fasciola sp. Bunga widuri (Calotropis gigantea) merupakan tumbuhan obat yang telah diketahui secara tradisional dapat mengobati kecacingan. Penelitian ini bertujuan menentukan efektivitas infus bunga widuri terhadap Fasciola sp. secara in vitro dan berdasarkan gambaran histologi tegumen. Penelitian ini bersifat eksperimental, dilaksanakan pada bulan Mei sampai September 2017 di Laboratorium Biologi FMIPA, Universitas Mataram. Pengujian secara in vitro terdiri dari enam kelompok: albendazol, kontrol negatif, infus bunga widuri konsentrasi 5%, 10%, 15%, dan 30% dengan parameter indeks pergerakan relatif dan ketahanan hidup. Preparat dibuat menggunakan metode parafin dan pewarnaan hematoksilin eosin. Data hasil perhitungan in vitro dianalisis dengan uji Kruskal-Wallis dan Mann-Whitney U Test. Analisis histologi pada bagian tegumen dilakukan secara deskriptif. Secara in vitro tidak ada pengaruh nyata (p<0,05) peningkatan konsentrasi terhadap penurunan waktu kematian cacing. Preparat histologi menunjukkan peningkatan konsentrasi infus seiring peningkatan kerusakan pada tegumen. Kesimpulan dari penelitian ini konsentrasi efektif infus bunga widuri adalah 5%. Kerusakan tegumen terbesar terjadi pada konsentrasi tertinggi.
Penyebaran Penyakit Brucellosis di Wilayah Koasistensi Administrasi Dinas dan Kesmavet
Authors: Primatika Roza Azizah , Sumiarto Bambang , Nugroho Widagdo Sri , Widiasih Dyah Ayu , Drastini Yatri , Yudhabuntara Doddy , Susetya Heru 
Published: October 2021

Brucellosis is a Brucella bacterial infectious disease that is spread from animals to humans, generally through consumption of milk, especially unpasteurized milk, or other dairy products. Veterinary public health has an important role in preventing transmission of disease to humans through both animals and foodstuffs of animal origin or other animal origin ingredients. Brucellosis is one of the problems often faced by the Animal Husbandry Department, especially at the Animal Health Unit. Handling and controlling about Brucellosis is very vital to maintain animal health and reduce the level of economic losses of farmers due to Brucellosis experienced by livestock owned. This study aims to determine the spread of Brucellosis disease by mapping in the Administrative and Service Coordination areas, to know the handling and control actions carried out by the Animal Husbandry Service throughout the implementation of the Administrative Coordination Office and Veterinary Public Health. The results of the mapping of the spread of Brucellosis in the District of Veterinary Public Health and Public Service Administration Coordination can be divided into 3 groups with the number of cases <10, 10 - 66, and> 66. The number of cases between the range of 10 - 66 there are 3 regions, while the number of cases> 66 there are 2 regions. Keywords : Brucellosis; Mapping; Handling and Control; Descriptive Statistics
Analisis Epidemiologi Kasus Hipofungsi Ovarium pada Sapi Potong di Kabupaten Jepara
Authors: Salman Aldi , Prihatno Surya Agus , Sumiarto Bambang 
Published: October 2021

Hipofungsi ovarium menjadi kasus gangguan reproduksi yang memiliki angka kejadian paling tinggi di Jawa Tengah, dengan kerugian peternak karena panjangnya Calving Interval dan biaya pengobatan yang tinggi. Kualitas pakan seringkali dianggap menjadi menjadi penyebab hipofungsi ovarium, tetapi juga terdapat faktor lain yang mengakibatkan munculnya penyakit. Penelitian bertujuan untuk mengetahui prevalensi dan faktor risiko hipofungsi ovarium pada sapi potong, serta model untuk memprediksi penyakit hipofungsi ovarium di Kabupaten Jepara. Sapi betina produktif sebanyak 304 ekor sampel dari 176 peternak dipilih secara formal random sampling pada 14 desa di 7 kecamatan dengan tahapan ganda. Dilakukan anamnesis pada peternak dan pemeriksaan sapi secara per rektal untuk mengetahui status reproduksi, serta kuesioner untuk tingkat peternakan dan individu ternak. Hasil penelitian menunjukkan prevalensi hipofungsi ovarium 8,88% dan faktor risiko yang mempunyai hubungan adalah frekuensi pakan tambahan/PKTB (OR=12,77) dan pakan utama/PKUT (OR=9,59). Variabel yang menurunkan hipofungsi ovarium adalah jenis ternak/JNT (OR=0,37), kepemilikan ternak satu/PUNYA1 (OR=0,34), umur ternak/UMT (OR=0,32), status laktasi/STLAK (OR=0,07) dan umur sapih/SAPH (OR=0,027). Model persamaan pada tingkat ternak adalah Ln P/1-P = 5,709 - 3,198xSAPH - 1,825xSTLAK - 0,992xJNTR. Model persamaan pada tingkat peternakan adalah Ln P/1-P = 1,213 + 1,813xPKUT + 1,736xPKTB - 1,331xPUNYA1