bluuebunny/crossref_metadata_2025_split huggingface dataset:
Venetoclax in relapsed/refractory blastic plasmacytoid dendritic cell neoplasm with central nervous system involvement: a case report and review of the literature
Authors: Albiol Nil , Novelli Silvana , Mozos Anna , Pratcorona Marta , Martino Rodrigo , Sierra Jorge 
Published: June 2021

Abstract
Background
We describe a patient with blastic plasmacytoid dendritic cell neoplasm with central nervous system involvement and the outcome of venetoclax use in this setting.

Case presentation
A 54-year-old Caucasian male was referred to the Haematology Unit with an enlarged inguinal lymph node which was diagnostic of a blastic plasmacytoid dendritic cell neoplasm. The staging revealed disseminated disease (skin, visceral, lymph nodes, and bone marrow). He received chemotherapy with an acute myeloid leukaemia-like regime. Afterwards, he underwent allogeneic haematopoietic stem cell transplantation, though it was not successful, showing a relapse 14 months later with hepatic and central nervous system dissemination. Intrathecal chemotherapy was administered, and venetoclax (anti-bcl2 agent) was started in an off-label indication based on most recent literature. The disease halted its course for 3 months. In the end, the patient’s disease progressed and so he succumbed due to infectious complications.

Conclusions
Venetoclax monotherapy seems not enough to control the disease progression under CNS involvement and other treatments should be investigated.
Proceedings of the Canadian Thyroid Cancer Active Surveillance Study Group 2019 national investigator meeting
Authors: Goldstein David P. , Ghai Sangeet , Corsten Martin , Bissada Eric , Audet Nathalie , Zhang Han , Nichols Anthony , Morrison Deric , Johnson-Obeski Stephanie , Anderson Donald W. , Prisman Eitan , Baxter Nancy N. , Jones Jennifer , Gafni Amiram , Witterick Ian , Sawka Anna M. 
Published: June 2021

Active surveillance (AS) in the management of small, low risk papillary thyroid cancer (PTC) as an alternative option to thyroidectomy, is an area of active research. A national Canadian study is proposed to evaluate the long-term outcomes of patients with small, low risk PTC who choose AS or surgery. This letter describes the proceedings of a national investigator meeting to plan the study. Graphical abstract
Instructional improv to analyze inquiry-based science teaching: Zed’s dead and the missing flower
Authors: Dahn Maggie , Lee Christine , Enyedy Noel , Danish Joshua 
Published: June 2021

AbstractIn inquiry-based science lessons teachers face the challenge of adhering to curricular goals while simultaneously following students’ intuitive understandings. Improvisation (improv) provides a useful frame for understanding teaching in these inquiry-based contexts. This paper builds from prior work that uses improv as a metaphor for teaching to present a translated model for analysis of teaching in an inquiry-based, elementary school science lesson context. We call our model instructional improv, which shows how a teacher spontaneously synthesizes rules of improv with teaching practices to support student learning, engagement, and agency. We illustrate instructional improv through case study analysis of video recorded classroom interactions with one teacher and 26 first and second grade students learning about the complex system of honey bee pollination in a mixed reality environment. Our model includes the following defining features to describe how teaching happens in this context: the teacher 1) tells a story; 2) reframes mistakes as opportunities; 3) agrees; 4) yes ands; 5) makes statements (or asks questions that elicit statements); and 6) puts the needs of the classroom ensemble over individuals. Overall, we show how instructional improv helps explain how teachers can support science discourse and collective storytelling as a teacher (a) shifts power and agency to students; (b) balances learning and agency; and (c) makes purposeful instructional decisions. Findings have immediate implications for researchers analyzing interactions in inquiry-based learning environments and potential future implications for teachers to support inquiry learning.
Towards probing Earth’s upper mantle with daily magnetic field variations: exploring a physics-based parametrization of the source
Authors: Zenhäusern Géraldine , Kuvshinov Alexey , Guzavina Martina , Maute Astrid 
Published: June 2021

AbstractThe electromagnetic (EM) field variations capable of probing the electrical conductivity of the upper mantle and mantle transition zone have a period range between a few hours and 1 day. At these periods, the dominant source of the EM signals is the ionospheric current system, which has a complex spatial and temporal structure. A concept of global-to-local (G2L) transfer functions can handle spatially complex source by relating global source expansion coefficients with locally measured magnetic (or/and electric) fields. When estimating the G2L transfer functions, the source is commonly expanded into spherical harmonics (SH). In this paper, we explore an alternative parametrization of the source based on a principal component analysis (PCA) of the Fourier transformed output from the physics-based Thermosphere Ionosphere Electrodynamics General Circulation Model (TIE-GCM). Specifically, we investigate whether magnetic fields computed in the realistic three-dimensional conductivity model of Earth excited by the PCA-based source agree better with observatory data than those computed in the same model but induced by the SH-based source. Using PCA to capture the source current compared to SH parametrization, we find that agreement with the observatory data is better during magnetically disturbed times and at shorter periods. Vice versa, it is poorer during magnetically quiet times and at longer periods.
Application of deep learning-based neural networks using theoretical seismograms as training data for locating earthquakes in the Hakone volcanic region, Japan
Authors: Sugiyama Daisuke , Tsuboi Seiji , Yukutake Yohei 
Published: June 2021

AbstractIn the present study, we propose a new approach for determining earthquake hypocentral parameters. This approach integrates computed theoretical seismograms and deep machine learning. The theoretical seismograms are generated through a realistic three-dimensional Earth model, and are then used to create spatial images of seismic wave propagation at the Earth’s surface. These snapshots are subsequently utilized as a training data set for a convolutional neural network. Neural networks for determining hypocentral parameters such as the epicenter, depth, occurrence time, and magnitude are established using the temporal evolution of the snapshots. These networks are applied to seismograms from the seismic observation network in the Hakone volcanic region in Japan to demonstrate the suitability of the proposed approach for locating earthquakes. We demonstrate that the determination accuracy of hypocentral parameters can be improved by including theoretical seismograms for different earthquake locations and sizes, in the learning data set for the deep machine learning. Using the proposed method, the hypocentral parameters are automatically determined within seconds after detecting an event. This method can potentially serve in monitoring earthquake activity in active volcanic areas such as the Hakone region.
Fishes of Lakshadweep archipelago: new records, review and a revised checklist
Authors: Rajan Rajkumar , Rajan P. T. , Mishra S. S. , C. N. Abdul Raheem , S. Shrinivaasu , C. Surendar , A. T. Damodhar 
Published: June 2021

AbstractExtensive studies on fish diversity in Lakshadweep waters began with Jones and Kumaran’s in 1964. Reports after these authors were sparse and sporadic until the turn of this century. Although recent reports have increased the tally, targeted studies are lacking, and there is a possibility of listing more species for this region. Studies on the diversity and abundance of fishes are due, given the atoll system undergoing rapid changes: structural decline due to several bleaching related coral mortality events, changes in the seagrass meadows, and the increase in fishing reef-associated species. These circumstances call for a revised checklist of fishes for this region, for the latest dates back to 1991. Thus, we present an inventory of ichthyofauna of Lakshadweep atolls based on published literature and incorporating 15 new species records identified through a rapid survey. The new species records for this region are presented here with the diagnostics of these species. The checklist shows 856 species of 432 genera, 43 orders, and 144 families known from these islands, including 16 freshwater forms. 49.3% of the contribution is from 14 fish families having > 15 species each, while the remainder 131 families contributed 52.5%, which have < 15 species. About 154 species belonging to 12 families are known to contribute to the commercial fisheries of these islands. The new records reported in this work for this region are found in the Maldives, and Sri Lanka proves the zoogeographical affinity of these two regions with the Lakshadweep archipelago.
Cardiovascular risk comorbidities in rheumatoid arthritis patients and the use of anti-rheumatic drugs: a cross-sectional real-life study
Authors: Vicente Gustavo Nogueira Schincariol , Pereira Ivânio Alves , de Castro Gláucio Ricardo Werner , da Mota Licia Maria Henrique , Carnieletto Ana Paula , de Souza Dhara Giovanna Santin , da Gama Fabiana Oenning , Santos Ana Beatriz Vargas , de Albuquerque Cleandro Pires , Bértolo Manoel Barros , Júnior Paulo Louzada , Giorgi Rina Dalva Neubarth , Radominski Sebastião Cezar , Guimarães Maria Fernanda Brandão Resende , Bonfiglioli Karina Rossi , Sauma Maria de Fátima Lobato da Cunha , Brenol Claiton Viegas , da Rocha Castelar Pinheiro Geraldo 
Published: June 2021

AbstractBackgroundRheumatoid arthritis (RA) is a common autoimmune systemic inflammatory disease. In addition to joint involvement, RA patients frequently have other comorbidities, such as cardiovascular diseases. Drugs used for RA treatment may increase or decrease the risk of a cardiovascular event. This study aims to analyze cardiovascular risk comorbidities in patients with RA and the correlation with the use of anti-rheumatic drugs.MethodsCross-sectional study conducted based on the real-life rheumatoid arthritis study database – REAL, a prospective observational cohort study. Associations between the use of anti-rheumatic drugs and the presence of comorbidities were represented by their prevalence ratio and evaluated using the Chi-square or Fisher’s Exact tests.ResultsWe assessed 1116 patients, 89.4% women, mean age of 55.15 years and predominance of seropositive disease. 63.3% had some cardiovascular comorbidity, predominantly hypertension (49.9%). The use of glucocorticoids was observed in 47.4% of patients and there was a significant tendency of lower use of these drugs in the presence of dyslipidemia (PR: 0.790;p = 0.007). We observed that the presence of cardiovascular comorbidities was associated with higher use of bDMARDs (PR:1.147;p = 0.003).ConclusionsThe presence of cardiovascular risk comorbidities was confirmed to be higher in RA patients. Different treatment strategies using less glucocorticoids in the presence of dyslipidemia and more common use of bDMARDs in patients with cardiovascular comorbidities suggest that rheumatologists are aware of the potential influence of the DMARDs in the risk of cardiovascular event. Reinforcing these results, we highlight the need for a better baseline assessment to guide the choice of anti-rheumatic drugs in RA patients who have comorbidities.
Immediate weight-bearing is safe following lateral locked plate fixation of periprosthetic distal femoral fractures
Authors: Keenan Oisin J. F. , Ross Lauren A. , Magill Matthew , Moran Matthew , Scott Chloe E. H. 
Published: June 2021

Abstract
Purpose
This study aimed to determine whether unrestricted weight-bearing as tolerated (WBAT) following lateral locking plate (LLP) fixation of periprosthetic distal femoral fractures (PDFFs) is associated with increased failure and reoperation, compared with restricted weight-bearing (RWB).

Materials and methods
In a retrospective cohort study of consecutive patients with unilateral PDFFs undergoing LLP fixation, patients prescribed WBAT were compared with those prescribed 6 weeks of RWB. The primary outcome measure was reoperation. Kaplan–Meier and Cox multivariable analyses were performed.

Results
There were 43 patients (mean age 80.9 ± 11.7 years, body mass index 26.8 ± 5.7 kg/m2 and 86.0% female): 28 WBAT and 15 RWB. There were more interprosthetic fractures in the RWB group (p = 0.040). Mean follow-up was 3.8 years (range 1.0–10.4). Eight patients (18.6%) underwent reoperation. Kaplan–Meier analysis demonstrated no difference in 2-year survival between WBAT (80.6%, 95% CI 65.3–95.9) and RWB (83.3%, 95% CI 62.1–100.0; p = 0.54). Cox analysis showed increased reoperation risk with medial comminution (hazard ratio 10.7, 95% CI 1.5–80; p = 0.020) and decreased risk with anatomic reduction (hazard ratio 0.11, 95% CI 0.01–1.0; p = 0.046). Immediate weight-bearing did not significantly affect the risk of reoperation compared with RWB (relative risk 1.03, 95% CI 0.61–1.74; p = 0.91).

Conclusions
LLP fixation failure was associated with medial comminution and non-anatomic reductions, not with postoperative weight-bearing. Medial comminution should be managed with additional fixation. Weight-bearing restrictions additional to this appear unnecessary and should be avoided.
Fasting Plasma Glucose and Incident Colorectal Cancer: Analysis of a Nationwide Epidemiological Database
Authors: Itoh Hidetaka , Kaneko Hidehiro , Okada Akira , Yano Yuichiro , Morita Kojiro , Seki Hikari , Kiriyama Hiroyuki , Kamon Tatsuya , Fujiu Katsuhito , Matsuoka Satoshi , Nakamura Sunao , Michihata Nobuaki , Jo Taisuke , Takeda Norifumi , Morita Hiroyuki , Nishiyama Akira , Node Koichi , Yasunaga Hideo , Komuro Issei 
Published: June 2021

Abstract

Context
Although diabetes mellitus (DM) was reported to be associated with incident colorectal cancer (CRC), the detailed association between fasting plasma glucose (FPG) and incident CRC has not been fully understood.

Objective
We assessed whether hyperglycemia is associated with a higher risk for CRC.

Design
Analyses were conducted using the JMDC Claims Database [n = 1 441 311; median age (interquartile range), 46 (40-54) years; 56.6% men). None of the participants were taking antidiabetic medication or had a history of CRC, colorectal polyps, or inflammatory bowel disease. Participants were categorized as normal FPG (FPG level &lt; 100 mg/dL; 1 125 647 individuals), normal-high FPG (FPG level = 100-109 mg/dL; 210 365 individuals), impaired fasting glucose (IFG; FPG level = 110-125 mg/dL; 74 836 individuals), and DM (FPG level ≥ 126 mg/dL; 30 463 individuals).

Results
Over a mean follow-up of 1137 ± 824 days, 5566 CRC events occurred. After multivariable adjustment, the hazard ratios for CRC events were 1.10 (95% CI 1.03-1.18) for normal-high FPG, 1.24 (95% CI 1.13-1.37) for IFG, and 1.36 (95% CI 1.19-1.55) for DM vs normal FPG. We confirmed this association in sensitivity analyses excluding those with a follow-up of&lt; 365 days and obese participants.

Conclusion
The risk of CRC increased with elevated FPG category. FPG measurements would help to identify people at high-risk for future CRC.
Neurodevelopmental Disorders, Glycemic Control, and Diabetic Complications in Type 1 Diabetes: a Nationwide Cohort Study
Authors: Liu Shengxin , Kuja-Halkola Ralf , Larsson Henrik , Lichtenstein Paul , Ludvigsson Jonas F , Svensson Ann-Marie , Gudbjörnsdottir Soffia , Tideman Magnus , Serlachius Eva , Butwicka Agnieszka 
Published: June 2021

Abstract

Context
Neurodevelopmental disorders are more prevalent in childhood-onset type 1 diabetes than in the general population, and the symptoms may limit the individual’s ability for diabetes management.

Objective
This study investigated whether comorbid neurodevelopmental disorders are associated with long-term glycemic control and risk of diabetic complications.

Methods
This population-based cohort study used longitudinally collected data from Swedish registers. We identified 11 326 individuals born during 1973-2013, diagnosed with type 1 diabetes during 1990-2013 (median onset age: 9.6 years). Among them, 764 had a comorbid neurodevelopmental disorder, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, and intellectual disability. We used multinomial logistic regression to calculate odds ratios (ORs) of having poor glycemic control (assessed by glycated hemoglobin [HbA1c]) and Cox regression to estimate hazard ratios (HRs) of nephropathy and retinopathy.

Results
The median follow-up was 7.5 years (interquartile range [IQR] 3.9, 11.2). Having any neurodevelopmental disorder (ORadjusted 1.51 [95% CI 1.13, 2.03]), or ADHD (ORadjusted 2.31 [95% CI 1.54, 3.45]) was associated with poor glycemic control (mean HbA1c &gt; 8.5%). Increased risk of diabetic complications was observed in patients with comorbid neurodevelopmental disorders (HRadjusted 1.72 [95% CI 1.21, 2.44] for nephropathy, HRadjusted 1.18 [95% CI 1.00, 1.40] for retinopathy) and patients with ADHD (HRadjusted 1.90 [95% CI 1.20, 3.00] for nephropathy, HRadjusted 1.33 [95% CI 1.07, 1.66] for retinopathy). Patients with intellectual disability have a particularly higher risk of nephropathy (HRadjusted 2.64 [95% CI 1.30, 5.37]).

Conclusion
Comorbid neurodevelopmental disorders, primarily ADHD and intellectual disability, were associated with poor glycemic control and a higher risk of diabetic complications in childhood-onset type 1 diabetes.
Highly Selective and Sensitive Detection of Hg(I), Hg(II) Ions by a Covalent Organic Framework Embedding Active Sulfur Sites in the Pore Wall
Authors: Zheng Ming-Xin , Yao Chan , Xie Wei , Xu Yan-Hong , Hu Hui 
Published: June 2021

Abstract
Mercury is a toxic substance that is harmful to human health and the environment. It is a great challenge to overcome the pollution of mercury via designing suitable adsorbent decorated with abundant chelating sites on a solid surface together with high affinity for heavy metals. Herein, we employed a flexible building block 4,4′-dithiodianiline as a connector, and together with tetraphenylethylene tetraaldehyde to construct a periodic 3D extended framework with bright green-yellow luminescence (TPE-S-COF), in which the active sites of sulfur are uniformly distributed in pore walls. This allows TPE-S-COF to be used as a sensitive chemosensor to selectively detect toxic mercury ions; and has an adsorption capacity of 48 and 42.4 mg g−1 for Hg+ or Hg2+, respectively. More interestingly, the detection performance of TPE-S-COF towards mercury ions can be directly observed by the naked eye. And, it can be reused without loss of sensitivity and responsiveness.
Photodynamic and Photothermal Effects of Carbon Dot-Coated Magnetite- and Porphyrin-Conjugated Confeito-Like Gold Nanoparticles
Authors: Do Thu Thi Anh , Imae Toyoko 
Published: June 2021

Abstract
Gold nanoparticles (AuNPs) possess the characteristics of both inertness and biocompatibility which enable great biomedical application in biosensors and drug delivery. Confeito-like AuNPs conjugated with porphyrin (TCPP) were synthesized and characterized to clarify the photodynamic and photothermal properties. The conjugation of TCPP was performed by covalent binding using L-cysteine or carbon dot-protected iron oxide (Fe3O4@Cdots) as adapted linkages. The product had a great aptitude for photosensitization performance and improved the efficiency of singlet oxygen generation, indicating the possible photodynamic properties in an order of AuNPs &lt; Cdots &lt; TCPP. TCPP could be best used for photodynamic application, and carbon dots and confeito-like AuNPs conjugated with TCPP could improve the effectiveness of photodynamic properties. Moreover, magnetite displayed excellent photothermal property better than that of AuNPs, while Cdots and TCPP do not contribute to the photothermal performance. Thus, this study confirmed that Fe3O4@Cdot-conjugated confeito-like AuNPs are available for both photodynamic and photothermal therapeutic application.
Impact of nurse-initiated education on HeartScore in patients with hypertension: a randomised trial
Authors: Chatziefstratiou Anastasia A , Fotos Nikolaos V , Giakoumidakis Konstantinos , Brokalaki Hero 
Published: June 2021

Background: People with hypertension experience significant damage to major organs due to insufficient management of cardiovascular risk factors. Aims: To assess the impact of nurse-led educational interventions on the total cardiovascular risk among people with hypertension. Method: the study was an interventional randomised study. The sample (n=92) was randomly assigned to the either the control or intervention group. The HeartScore tool was used to assess patients' total cardiovascular risk between December 2017 and March 2018. Findings: 56.6% of the control group and 55.4% of the intervention group were women, with a mean age of 64.4 years and 66.2 years respectively (P>0.05). Total cholesterol reduced in both groups; however, improvement was greater in the intervention group (P<0.05). Total cardiovascular risk fell in the intervention group from 4.75 to 4.33 (P>0.05), while the control group saw an increase in risk from 10.03 to 12.65 (P=0.035). Conclusion: Nurse-led educational interventions should be incorporated in the usual care of patients with hypertension, in order to achieve the best management of the condition.
Redeployment during the first wave of the COVID-19 pandemic: implications for a clinical research workforce
Authors: Walker Kathryn Louise , Gerakios Florence 
Published: June 2021

Background:Health professionals are considered a group vulnerable to developing mental health symptoms during a pandemic, with redeployment being a risk factor. However, previous literature suggests workplace communication can be a protective element.Aims:An audit aimed to evaluate NHS research staff's experiences of redeployment in order to provide suggestions for future improvements in the process.Methods:A questionnaire was disseminated to all staff in the clinical research directorate of an NHS trust. Responses were analysed using thematic analysis.Findings:Over half the redeployed staff experienced perceived negative psychological outcomes. The main reported contributor to this was perceived lack of communication.Conclusion:Communication needs to be improved in future redeployments. Future research should consider a larger cohort and more input from team members who remained on the pre-COVID-19 studies in order to improve the transition back from redeployment.
Emergency management of neck stoma patients during the coronavirus pandemic: a national nurse survey
Authors: Senior Andrew , Chan Jacquline , Brookes Kim , Jolly Karan , Darr Adnan , Ameen Rohan 
Published: June 2021

Background: Neck stoma patient care involves significant clinical complexity. Inadequate staff training, equipment provision and infrastructure have all been highlighted as causes for avoidable patient harm. Aims: To establish the perception of knowledge and confidence levels relating to the emergency management of neck stomas among UK nurses during the COVID-19 pandemic. Method: A nationwide prospective electronic survey of both primary and secondary care nurses via the Royal College of Nursing and social media. Findings: 402 responses were collated: 81 primary care and 321 secondary care; the majority (n=130) were band 5. Forty-nine per cent could differentiate between a laryngectomy and a tracheostomy; ENT nurses scored highest (1.56; range 0−2) on knowledge. Fifty-seven per cent could oxygenate a tracheostomy stoma correctly and 54% could oxygenate a laryngectomy stoma correctly. Sixty-five per cent cited inadequate neck stoma training and 91% felt inclusion of neck stoma training was essential within the nursing curriculum. Conclusion: Clinical deficiencies of management identified by nurses can be attributed to a lack of confidence secondary to reduced clinical exposure and education.