bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using informative features in machine learning based method for COVID-19 drug repurposing
Authors: Aghdam Rosa , Habibi Mahnaz , Taheri Golnaz 
Published: September 2021

AbstractCoronavirus disease 2019 (COVID-19) is caused by a novel virus named Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). This virus induced a large number of deaths and millions of confirmed cases worldwide, creating a serious danger to public health. However, there are no specific therapies or drugs available for COVID-19 treatment. While new drug discovery is a long process, repurposing available drugs for COVID-19 can help recognize treatments with known clinical profiles. Computational drug repurposing methods can reduce the cost, time, and risk of drug toxicity. In this work, we build a graph as a COVID-19 related biological network. This network is related to virus targets or their associated biological processes. We select essential proteins in the constructed biological network that lead to a major disruption in the network. Our method from these essential proteins chooses 93 proteins related to COVID-19 pathology. Then, we propose multiple informative features based on drug–target and protein−protein interaction information. Through these informative features, we find five appropriate clusters of drugs that contain some candidates as potential COVID-19 treatments. To evaluate our results, we provide statistical and clinical evidence for our candidate drugs. From our proposed candidate drugs, 80% of them were studied in other studies and clinical trials.
Long-term cost-effectiveness of interventions for loss of electricity/industry compared to artificial general intelligence safety
Authors: Denkenberger David , Sandberg Anders , Tieman Ross John , Pearce Joshua M. 
Published: September 2021

AbstractExtreme solar storms, high-altitude electromagnetic pulses, and coordinated cyber attacks could disrupt regional/global electricity. Since electricity basically drives industry, industrial civilization could collapse without it. This could cause anthropological civilization (cities) to collapse, from which humanity might not recover, having long-term consequences. Previous work analyzed technical solutions to save nearly everyone despite industrial loss globally, including transition to animals powering farming and transportation. The present work estimates cost-effectiveness for the long-term future with a Monte Carlo (probabilistic) model. Model 1, partly based on a poll of Effective Altruism conference participants, finds a confidence that industrial loss preparation is more cost-effective than artificial general intelligence safety of ~ 88% and ~ 99+% for the 30 millionth dollar spent on industrial loss interventions and the margin now, respectively. Model 2 populated by one of the authors produces ~ 50% and ~ 99% confidence, respectively. These confidences are likely to be reduced by model and theory uncertainty, but the conclusion of industrial loss interventions being more cost-effective was robust to changing the most important 4–7 variables simultaneously to their pessimistic ends. Both cause areas save expected lives cheaply in the present generation and funding to preparation for industrial loss is particularly urgent.
A comparison of methods for the long-term harness-based attachment of radio-transmitters to juvenile Japanese quail (Coturnix japonica)
Authors: Buck Evan J. , Sullivan Jeffery D. , Kent Cody M. , Mullinax Jennifer M. , Prosser Diann J. 
Published: September 2021

Abstract
Background
While the period from fledging through first breeding for waterbird species such as terns (e.g., genus Sterna, Sternula) is of great interest to researchers and conservationists, this period remains understudied due in large part to the difficulty of marking growing juveniles with radio transmitters that remain attached for extended periods.

Methods
In an effort to facilitate such research, we examined the impact of various combinations of harness types (backpack, leg-loop, and 3D-printed harnesses), harness materials (Automotive ribbon, Elastic cord, and PFTE ribbon), and transmitter types (center-weighted and rear-weighted) on a surrogate for juvenile terns, 28-day-old Japanese quail (Coturnix japonica; selected due to similarities in adult mass and downy feathering of juveniles), in a 30-day experiment. We monitored for abrasion at points of contact and tag gap issues via daily exams while also recording mass and wing cord as indices of growth. This study was designed to serve as an initial examination of the impacts of marking on the growth and development of young birds and does not account for any impacts of tags on movement or behavior.

Results
While we found that treatment (the specific combination of the transmitter type, harness type, and harness material) had no impact on bird growth relative to unmarked control birds (P ≥ 0.05), we did observe differences in abrasion and tag gap between treatments (P ≤ 0.05). Our results suggest that leg-loop harnesses constructed from elastic cord and backpack harnesses from PFTE ribbon are suitable options for long-term attachment to growing juveniles. Conversely, we found that automotive ribbon led to extensive abrasion with these small-bodied birds, and that elastic cord induced blisters when used to make a backpack harness.

Conclusions
While these results indicate that long-term tagging of juvenile birds is possible with limited impacts on growth, this work does not preclude the need for small-scale studies with individual species. Instead, we hope this provides an informed starting point for further exploration of this topic.
Visualizing the cultural landscape gene of traditional settlements in China: a semiotic perspective
Authors: Hu Zui , Strobl Josef , Min Qingwen , Tan Min , Chen Fulong 
Published: September 2021

Abstract
China has a deep traditional culture and a long history, and is rich in traditional settlements (designated as “Famous Historic-Cultural Villages/Towns”, “Chinese Traditional Villages” by Chinese Government). To help people develop these traditional settlements to achieve the great goal of Chinese National Rejuvenation, Chinese scholar put forward the Cultural Landscape Genes of Traditional Settlements (CLGTS) in 2003. Since then, CLGTS theory has been employed to solve the issues of Chinese traditional settlements, such as the identification and regionalization of cultural landscape genes in traditional settlements, and the understanding of architectural features. Although CLGTS theory has made great strides in many application fields, there is still a lack of scientific findings in exploring the symbol mechanism from a perspective of semiotics. To explore this, we firstly examined the core features of CLGTS through a dialectical perspective. We analyzed two features of CLGTS in depth. First, CLGTS is the dialectical combination of macro settlement image and micro cultural factors of traditional settlements, material appearance and inherent traditional cultural implications, overall features and local self-renewal mechanisms, qualitative and quantitative methods, superiority of cultural factors and rich cultural connotation. Second, CLGTS is famous for its nonlinearity, self-organization, and self-iteration due to various spatial shapes and complex structures. Based on the above, we first proposed the concept of Symbolization Method of CLGTS (SM-CLGTS). Then, we further explored the key features, classification methods, and corresponding representation methods of CLGTS symbols. Finally, by using Visual C#.net program language, we developed a prototype system of the Traditional Landscape Genetic Symbol Database (TLGSD) to create and centrally manage CLGTS symbols. Test results show that TLGSD can meet the needs of constructing a CLGTS symbol database for a given region. This study is of great significance to explore and contribute to visualizing the CLGTS symbols.
Immature granulocytes can help the diagnosis of pulmonary bacterial infections in patients with severe COVID-19 pneumonia
Authors: Daix Thomas , Jeannet Robin , Hernandez Padilla Ana Catalina , Vignon Philippe , Feuillard Jean , François Bruno 
Published: September 2021

AbstractDuring COVID-19, immature granulocyte (IG) concentration is heterogeneous with higher concentrations than those found in bacterial sepsis. We investigated the relationship between IG levels at ICU admission and on days 7 (± 2) and 15 (± 2) and associated pulmonary bacterial infections in intensive care unit (ICU) patients hospitalized for an acute respiratory distress syndrome (ARDS) related to SARS-CoV-2. Patients with associated pulmonary bacterial infection had a peak of IGs. IG thresholds of 18% or 2 G/L allowed discriminating patients with ventilator associated pneumonia with 100% sensitivity and specificity. Our study supports that IGs could help identifying pulmonary bacterial infections in this population.
Evaluation of chemical and microbial quality of food in northern Iran
Authors: Aghalari Zahra , Hosseini Seyed Reza , Jafarian Somayeh , Rezazadeh Mohsen , Mirzaei Mohsen , Esmaeili Ebrahim , Hasanzadeh Peyman 
Published: September 2021

Abstract
Background
Iran is one of the developing countries and foodborne diseases commonly impose problems for public health, the health care system and the economy. Therefore, this study aimed to evaluate the chemical and microbial quality of food in northern Iran.

Methods
This cross-sectional study was conducted in 2019. This study was performed on food samples obtained in a straightforward way while visiting food preparation and distribution centers in Babol. Tests related to different food types were performed by laboratory experts. Data collection with a checklist: date and place of sampling, number of samples, type of food, type of test, compliance of results with standards. Data were analyzed by SPSS22 and descriptive statistics, Chi-square and t-test.

Results
1043 food samples were tested from 5 groups of dairy products, protein, cereals, vegetables and other food groups. The highest number of samples in the cereal group was 767 samples (73.53%). In the cereal group, most samples were breads. The pH of 11.67% of breads and the salt in 21.49% of breads did not match the standard. The blankit (sodium hydrosulfite) on bread dough were negative. Moisture, gluten, ash and pH match with the standards in all flour samples. The results of microbial tests on sweets and ice cream showed that Escherichia coli and Staphylococcus aureus and Salmonella were negative. Enterobacter aerogenes was positive in 8.20% of sweets, mold and yeast were positive in 19.58%. The results of microbial tests on buttermilk and yogurt, grilled meat and chicken sandwiches, vegetables and salads showed that bacteria Escherichia coli and Staphylococcus aureus and all microorganisms were negative. Mold tests were positive in 11.12% of juice samples.

Conclusions
The results showed that the foods and drinks supplied in food and drink preparation and distribution centers in Babol in 2019 were of good chemical and microbial quality. In some food groups the results of microbial and chemical testings were negative, i.e. without contamination. Less than 20% of products in the group of cereals and protein products did not match with the standards, which is a satisfactory result compared to other studies conducted in different cities of Iran. These good results for food quality can be explained bythe constructive performance of food health experts that made good controling, monitoring, and food health and hygiene education.
Validation and reliability of the Dutch version of the EORTC QLQ-NMIBC24 Questionnaire Module for patients with non-muscle-invasive bladder cancer
Authors: Ripping Theodora M. , Westhoff Ellen , Aaronson Neil K. , Van Hemelrijck Mieke , Rammant Elke , Witjes J. Alfred , Kiemeney Lambertus. A. , Aben Katja K. H. , Vrieling Alina 
Published: September 2021

Abstract
Background
The European Organisation for Research and Treatment of Cancer (EORTC) quality of life questionnaire for non-muscle invasive bladder cancer (QLQ-NMIBC24) has been available and applied for some years now, but has yet to undergo a full comprehensive psychometric evaluation. The aim of this study was to investigate the psychometric properties of the Dutch version of the EORTC QLQ-NMIBC24 questionnaire in patients with low, intermediate and high risk NMIBC.

Methods
We included patients newly diagnosed with NMIBC participating in the multicenter, population-based prospective cohort studies UroLife or BlaZIB. Psychometric evaluation included examination of the structural validity, reliability (i.e. internal consistency and test–retest reliability), construct validity (i.e. divergent validity and known-groups validity), responsiveness and interpretability.

Results
A total of 1463 patients who completed the baseline questionnaire of UroLife (n = 541, response rate 50%) or BlaZIB (n = 922, response rate 58%) were included. The percentage of missing responses were low for all non-sex related scales (< 1%) and ranged between 6.9% to 50.0% for sex-related scales. More than 15% of the patients obtained the lowest possible scores on nearly each scale (floor effect). The structural validity was adequate; the confirmatory factor analysis showed satisfactory results and all items of multiple items scales had higher within- than between-scale correlations. Reliability of the questionnaire was adequate for most multiple item scales (Cronbach’s α ≥ 0.70 and intraclass correlation coefficient ≥ 0.70), with exception of the scales ‘malaise’ and ‘bloating and flatulence’. The questionnaire also showed good construct validity; it showed low correlations with the items of the EORTC core questionnaire and was able to measure differences between risk-based subgroups. The responsiveness of the questionnaire was good, but the interpretability, i.e. minimal important change, could not be determined.

Conclusions
This study shows that the measurement properties of the EORTC QLQL-NMIBC24 are good; it has a good structural validity, reliability (i.e. internal consistency and test–retest reliability), construct validity (i.e. divergent validity and known-group validity), and responsiveness. Interpretability could not be assessed. This questionnaire can be used to measure and monitor health-related quality of life of patients with NMIBC.
Effects of insecticides and cultivars on panicle-feeding insect pest infestations and grain yield of sorghum (Sorghum bicolor (L.) Moench) in northern Ghana
Authors: Nboyine Jerry A. , Opare-Obuobi Kenneth , Yahaya Iddrisu , Badii Benjamin K. , Kusi Francis , Yahaya Asieku , Adazebra Gloria 
Published: September 2021

Abstract
Background
Panicle-feeding insects are a challenge in sorghum (Sorghum bicolor (L.) Moench) cultivation but most farmers do not protect the crop. Here, the effects of pest management in different sorghum cultivars on grain yields and the financial returns after protecting the crop from panicle-feeding insects was studied.

Results
There were significant insecticide treatments × cultivars/genotypes interaction effects for Stenodiplosis sorghicola, Clavigralla tomentosicollis, Nezara viridula, Dysdercus fasciantus and Riptortus dentipes. Generally, pest infestations were higher in the untreated control compared to K-Optimal- or NSO-treated sorghum. Infestations were also higher in compact-headed cultivars (Dorado and Kapaala) compared to those with open heads (CSSOR 08-V01 and CSSOR 10-V07). Damage was approximately 1.7-fold higher in the untreated controls than in NSO or K-Optimal. Grain yields were about 14% higher in NSO or K-Optimal treated sorghum than in controls. Gross margins were between 16- and 35-fold higher in protected sorghum compared to the untreated ones.

Conclusion
These findings suggest that an effective integrated pest management strategy for sorghum farmers must comprise cultivars that do not have compact heads, and the use of about two sprays of NSO or a synthetic pyrethroid when high numbers of panicle-feeding insects are observed during the growing season. Judicious use of insecticides and the “right” cultivar will improve the profitability of sorghum farmers with gross marginal returns that are at least 15-fold higher than that obtained by farmers who adopt only good agronomic practices without insecticide sprays.
Development and reliability of the histological THROMBEX-classification rule for thrombotic emboli of acute ischemic stroke patients
Authors: Ribbat-Idel Julika , Stellmacher Florian , Jann Florian , Kalms Nicolas , König Inke R. , Ohlrich Marcus , Royl Georg , Klotz Stefan , Kurz Thomas , Kemmling Andrè , Roessler Florian C. 
Published: September 2021

Abstract
Background
Thrombus histology has become a potential diagnostic tool for the etiology assessment of patients with ischemic stroke caused by embolic proximal vessel occlusion. We validated a classification rule that differentiates between cardiac and arteriosclerotic emboli in individual stroke patients. We aim to describe in detail the development of this classification rule and disclose its reliability.

Methods
The classification rule is based on the hypothesis that cardiac emboli arise out of separation thrombi and arteriosclerotic emboli result from agglutinative thrombi. 125 emboli recovered by thrombectomy from stroke patients and 11 thrombi serving as references for cardiac (n = 5) and arteriosclerotic emboli (n = 6) were Hematoxylin and eosin, Elastica-van Gieson and CD61 stained and rated independently by two histopathologists blinded to the presumed etiology by several pre-defined criteria. Intra- and interobserver reliabilities of all criteria were determined. Out of the different criteria, three criteria with the most satisfactory reliability values were selected to compose the classification rule that was finally adjusted to the reference thrombi. Reliabilities of the classification rule were calculated by using the emboli of stroke patients.

Results
The classification rule reached intraobserver reliabilities for the two raters of 92.9% and 68.2%, respectively. Interobserver reliability was 69.9%.

Conclusions
A new classification rule for emboli obtained from thrombectomy was established. Within the limitations of histological investigations, it is reliable and able to distinguish between cardioembolic and arteriosclerotic emboli.
COVID-19 infection initially presented by interstitial edematous pancreatitis and acute peri-pancreatic collection; the first CT case report in Egypt
Authors: Samir Ahmed , Elnekeidy Abdelaziz , El-Kady Enjy 
Published: September 2021

Abstract
Background
The extra-pulmonary computed tomography (CT) findings of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or coronavirus disease 2019 (COVID-19) have been described in the literature, including the neurologic, cardiac, and abdominal manifestations. Ischemic and inflammatory bowel changes were the most frequent abdominal CT findings. Acute pancreatitis was seldom found all over the world outside of China and described in case reports, but not in Egypt.

Case presentation
A 44-years-old female patient presented with severe abdominal pain, vomiting, and mild fever for six days. No respiratory symptoms were encountered till the time of the radiological investigation. Abdominal CT examination revealed interstitial edematous pancreatitis with acute peri-pancreatic fluid collection according to the revised Atlanta classification. No pancreatic necrosis or vascular complications were depicted. Secondary pyloro-duodenitis was noticed. The modified Balthazar CT-severity index was moderate (6/10). Basal chest scans showed bilateral variable-sized bronchocentric and sub-pleural consolidative pneumonic patches with mild bilateral pleural effusion. The patient was admitted to the intensive-care unit (ICU) for two weeks. The serum amylase and lipase titers were elevated and the polymerase chain reaction (PCR) test for COVID-19 was positive. She received pancreatic, circulatory, and pulmonary medical support, then she was discharged after stabilization of her condition.

Conclusion
The authors provided this case report for the association between COVID-19 infection and acute pancreatitis, which is mostly the first in Egypt. It documented their Egyptian experience to be added to the international literature. It radiologically described their chest and abdominal CT findings in detail using the COVID-19 Reporting and Data System (CO-RADS) and the revised Atlanta classification with modified Balthazar CT-severity index (CTSI). This could eventually enrich the radiological point of view in addition to the previously published clinical case reports.
Radioembolization With Chemotherapy for Colorectal Liver Metastases: A Randomized, Open-Label, International, Multicenter, Phase III Trial
Authors: Mulcahy Mary F. , Mahvash Armeen , Pracht Marc , Montazeri Amir H. , Bandula Steve , Martin Robert C. G. , Herrmann Ken , Brown Ewan , Zuckerman Darryl , Wilson Gregory , Kim Tae-You , Weaver Andrew , Ross Paul , Harris William P. , Graham Janet , Mills Jamie , Yubero Esteban Alfonso , Johnson Matthew S. , Sofocleous Constantinos T. , Padia Siddharth A. , Lewandowski Robert J. , Garin Etienne , Sinclair Philip , Salem Riad ,   for the EPOCH Investigators
Published: September 2021

PURPOSE To study the impact of transarterial Yttrium-90 radioembolization (TARE) in combination with second-line systemic chemotherapy for colorectal liver metastases (CLM). METHODS In this international, multicenter, open-label phase III trial, patients with CLM who progressed on oxaliplatin- or irinotecan-based first-line therapy were randomly assigned 1:1 to receive second-line chemotherapy with or without TARE. The two primary end points were progression-free survival (PFS) and hepatic PFS (hPFS), assessed by blinded independent central review. Random assignment was performed using a web- or voice-based system stratified by unilobar or bilobar disease, oxaliplatin- or irinotecan-based first-line chemotherapy, and KRAS mutation status. RESULTS Four hundred twenty-eight patients from 95 centers in North America, Europe, and Asia were randomly assigned to chemotherapy with or without TARE; this represents the intention-to-treat population and included 215 patients in the TARE plus chemotherapy group and 213 patients in the chemotherapy alone group. The hazard ratio (HR) for PFS was 0.69 (95% CI, 0.54 to 0.88; 1-sided P = .0013), with a median PFS of 8.0 (95% CI, 7.2 to 9.2) and 7.2 (95% CI, 5.7 to 7.6) months, respectively. The HR for hPFS was 0.59 (95% CI, 0.46 to 0.77; 1-sided P < .0001), with a median hPFS of 9.1 (95% CI, 7.8 to 9.7) and 7.2 (95% CI, 5.7 to 7.6) months, respectively. Objective response rates were 34.0% (95% CI, 28.0 to 40.5) and 21.1% (95% CI, 16.2 to 27.1; 1-sided P = .0019) for the TARE and chemotherapy groups, respectively. Median overall survival was 14.0 (95% CI, 11.8 to 15.5) and 14.4 months (95% CI, 12.8 to 16.4; 1-sided P = .7229) with a HR of 1.07 (95% CI, 0.86 to 1.32) for TARE and chemotherapy groups, respectively. Grade 3 adverse events were reported more frequently with TARE (68.4% v 49.3%). Both groups received full chemotherapy dose intensity. CONCLUSION The addition of TARE to systemic therapy for second-line CLM led to longer PFS and hPFS. Further subset analyses are needed to better define the ideal patient population that would benefit from TARE.