bluuebunny/crossref_metadata_2025_split huggingface dataset:
A short communication: Diphtheria outbreak, Tdap vaccination for adults
Authors: Jeevan P J Sabi 
Published: September 2021

Diphtheria cases continue to occur also in Madurai, Tamil Nadu despite a national vaccination program targeting the disease. Outbreaks of diphtheria are noted in areas of low immunization coverage. Last week our nephews came with swollen cheeks etc so forth and so on. Disease manifesting among older children and adults as in of the recent outbreaks from the Indian states of Andhra Pradesh, Karnataka, Delhi and Assam.Of these, immunized children, 88% were above 10 years of age.A booster second doses of Adacel is for person 8 years and above along with tetanus prophylaxia is given in addition to maintaining a high immunization coverage in the routine immunization program, with special emphasis on areas of low vaccination coverage is essential for preventing then emergence of diphtheria.
Genetic Relationship of Transcriptional Factor Genes in the Regulation of Cells Death in Arabidopsis: A Review
Authors: Khaskheli A.J. , Zhang L. , Khaskheli M.I. , Khaskheli A.A. , Qing L.H. 
Published: September 2021

The leaf yellowing is the first visible sign of senescence, which starts at the margins of the leaf and progresses to the blade. Although, transcriptional factor family genes generally encode meticulous regulators which perform a range of functions in turns regulating the physiological and developmental mechanism of plant stature. However, the genetic relationship of TFs genes in regulating the cell death of Arabidopsis is well not understood to date. TFs family in a plant regulates various developmental and stress responses in underline pathways. In our review we observed the genetic relationship of TFs genes in regulations of cell death in Arabidopsis. Given that, programmed cell death (PCD) being an active process that includes the expression of hundreds of genes. It is speculated that many TFs are involved in the core elements of the regulatory network. There are only a few factors that are being demonstrated in involving the regulation of cell death, by evaluating the leaf senescence appearances of knocking of mutants and by identifying downstream target genes. In this review, we have focused on the manifold roles of TFs during genetic relationships and the regulation of cell death in Arabidopsis. We also deliberated how the transcription factors family gene regulates the cells’ death by different hormonal stress, environmental strain and their role in retrograde signaling. For deep understanding of regulatory molecular mechanisms of cell death in the plant, future research may be hypothesized to collect appropriate evidence and a detailed study may be implemented on the upstream pathway with a specific targeted gene that recognizes the stress signals involved in cell death in plants. Also, crosstalk between mitochondria and chloroplast is mainly being focused to better understand the regulations of cell death in plants. Present review concludes that regulating the cell death of Arabidopsis is very important for meeting future global food needs, crop yields. Overexpression of ERF transcription factors genes relating cell death of Arabidopsis confers broad-spectrum resistance to pathogens and other abiotic stresses and can also make transgenic plants resistant to drought, salinity and freezing.
The Effects of Organic Fertilizer and Planting Type on Growth and Yield of Curcuma aromatica
Authors: Ben Trinh Thi , Linh Le Nguyen Tu , Giang Tran Thi Linh , Dao Vu Quang , Oanh Nguyen Thi Tu , Dang Luu Van , Thach Bui Dinh 
Published: September 2021

Background: Curcuma aromatica Salisb is an important medicinal herb in Vietnam. It is exploited naturally, so its production is limited and in danger of extinction. Studying an organic farming model is a necessary orientation to exploit, conserve and provide quality raw materials. Methods: The present study was conducted to investigate the effect of surface coating types (A1: without coating, A2: straw coating and A3: polymer coating) and organic fertilizer amount (B1: 0; B1: 15, B2: 20, B3: 25 and B4: 30 ton ha-1) on growth and yield of Curcuma aromatica Salisb. The experiment was designed in a factorial randomized complete block design (RCBD) with three replications. The traits studied were: survival plant’s rate (%), leaf area (cm2), plant height (cm), number of leaves, fresh weight (g/plant), dry weight (g/plant), phenolic content/area (mg/20 m2), curcumol content/area (mg/20 m2). Result: The results of the experiment revealed that surface coating types and organic fertilization and their interaction were significant in growth and yield of Curcuma aromatica Salisb.
Strengths and problems of families in contact with child protective services during the COVID-19 pandemic
Authors: Witte Susanne , Kindler Heinz 
Published: September 2021

Objective: The study investigates the dynamics within families in contact with child protective services in reaction to the Covid-19 pandemic as perceived by social workers. Based on the Family Adjustment and Adaptation Response (FAAR) model, strengths and problems are outlined.
Background: Following the first lockdown of public life in March 2020, concerns about children’s well-being have been raised. Practitioners and scientists alike worried that particularly children in families with multiple problems would suffer severe abuse and neglect. However, it remains unclear how these families have actually been affected by the Covid-19 pandemic and the measures to reduce transmission of SARS-CoV-2.
Method: Child protection caseworkers from 40 child and youth welfare authorities across Germany were interviewed twice via telephone. The first interview was conducted during summer 2020, and the second interview two months later. Caseworkers were questioned about their professional experience in their daily work since March 2020. Moreover, they provided information on the perceived effects of the Covid-19 pandemic on families in contact with child protective services.
Results: The interviews were analyzed using content analyses. Six overall challenges for families were identified. Families reacted differently to these. The caseworkers reported problems in families like increased parental conflict, media use, and alcohol consumption during the first lockdown. Nevertheless in some families, the caseworkers also perceived there to be less stress and tension during the lockdown in March 2020 due to fewer school requirements. Furthermore, some families were able to establish routines, activate resources, and find solutions for problems on their own. At the time of the second interview, some families’ problems had increased, particularly regarding children’s difficulties at school due to insufficient homeschooling.
Conclusion: The results show that the effects of the Covid-19 pandemic on child protection families are positive and negative. Some are resourceful in the face of adversities, and others show an aggravation of problems. The results are discussed in light of findings on family dynamics during the Covid-19 pandemic in other countries.
Ethanol extract of Imperata Cylindrica leaves inhibits proliferation and migration of HSC-3 cell lines
Authors: Roeslan Moehamad Orliando , Tasha Gabriella 
Published: September 2021

Background: Squamous cell carcinoma (SCC) is classified as the most common type of oral cancer up to 90% of all malignant neoplasm in the oral cavity. Currently, the only treatments for SCC are surgery and/or radiation or chemotherapy, which can cause various side effects. Cogon grass leaves (Imperata cylindrica) have been considered an alternative cancer treatment that may reduce side effects. Imperata cylindrica (I. cylindrica) leaf extract can inhibit cancer cell proliferation and migration by withholding the cell cycle in the gap 1/synthesis (G1/S) and gap 2/mitosis (G2/M) phases. Therefore, the levels of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) is decreased and cancer is not progressing. Purpose: The study aims to determine the effect of I. cylindrica leaf extract on the proliferation and migration of human oral squamous carcinoma-3 (HSC-3) cell lines. Methods: This in vitro experimental study was conducted with nine study groups. The treatment group was divided into seven concentrations—640 ppm, 320 ppm, 160 ppm, 80 ppm, 40 ppm, 20 ppm and 10 ppm. 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium-bromide (MTT) assay and scratch assay were carried out to assess the effect of I. cylindrica leaf extract on HSC-3 cell proliferation and migration. Results: Ethanol extract of I. cylindrica has a significant effect compared to the negative control towards the proliferation and migration of HSC-3 cells. Conclusion: This study shows that I. cylindrica ethanol leaf extract can inhibit proliferation and migration of HSC-3 cells.
SWOT analysis of subscriptions to printed and electronic periodicals
Authors: Gerasimenko A. Yu. , Suraeva N. V. 
Published: September 2021

The rapid development of digital technology has led to the need of replenishing library collections with both traditional and electronic resources. Against this backdrop, a topical question has emerged: In what proportion should the library collections be replenished with printed and electronic resources? This topic is of particular importance in the context of forming collections of periodicals. The purpose of the study was to assess the potential of print and electronic periodicals and identify criteria for selecting the optimal approach to replenishment of library collections.For the first time, an attempt was made to use the strategic planning method - SWOT analysis.The study contained three stages, the description and the results of each are presented in the article. The analysis resulted in assessing the potential of electronic and printed periodicals to provide information services and proposing criteria for choosing the format of subscriptions to periodicals.
Directions of scientific research in the Ural Branch of the RAS (scientometric analysis of publications)
Authors: Prokof’eva Yu. D. , Peksheva M. A. 
Published: September 2021

Compliance of studies with the priority directions of scientific development in the country is an important factor in realizing the research potential of scholars. The article analyzes the directions of scientific research held in the Ural Branch of the Russian Academy of Sciences (UB RAS) organizations and their interdisciplinary interactions in the context of RF priority areas of science and technology development. The research bases on the content analysis of strategic documents at the national and federal levels, programs for the development of the scientific sphere (Forecast of scientific and technological development of the Russian Federation for the period up to 2030) and the analysis of scientific activities of the institutes of the Ural Branch based on scientometric data (Scopus).It is revealed that the leading research directions of Ural scientists enter scientific fields, which, due to the Forecast, are promising for science and technology development. These areas include “Materials Science”, “Biochemistry and Molecular Biology”, “Medicine”, “Immunology and Microbiology”, “Pharmacology, Toxicology, Pharmacy”, “Energy”.Fundamental scientific fields, not dir ectly reflected in the key areas of science and technology development, contribute to their development through the established interdisciplinary ties. They include “Physics and Astronomy”, “Chemistry”, “Engineering”, “Mathematics” and others. Researches on interdisciplinary problems have greater potential for international cooperation.
Algorithms for contactless scanning of book monuments
Authors: Sivkov S. I. , Simakov S. P. , Vinokur A. I. 
Published: September 2021

The article is devoted to the questions of cultural heritage preservation by creating the digital collection of book monuments. The original documents are monuments of book culture and their dilapidated state requires careful handling, splitting of documents for scanning is extremely undesirable. The market does not present the equipment for contactless scanning of books without embroidering, therefore an algorithm that allows digitalizing book monuments in a contactless way has been developed. The technique has been constructed using an algorithm based on the projection of the light grid on the object scanned. The authors propose a sequence of actions consisting of image processing and comparing the results between two images. The first snapshot determines the initial parameters of the grid; the second snapshot determines the actual distortion of the test snapshot. Subsequent mathematical processing allows getting scanned images without absence of geometric distortions of the scanned page due to the system of using the two-dimensional array of corrections. The application of the system has been modeled on the example of «The legend of the destruction of Siberian cities of Tara and Tyumen by the lesser Tatars / / Collection of moral stories, words, lives and other articles [hand.]». The evaluation parameters of the simulation result have been the following: text distinctness, absence of geometric distortions, color quality, uniformity of document scanning quality within a single book, etc., as checked and recognized as high by the experts.The experience described opens possibilities of book monuments digitization using the new algorithm. The development of the system is aimed at expanding the database of objects of material culture to be digitized, perfecting the software, improving the quality of digital images, as well as the capabilities of image recognition and search for the document itself and information it contains.
How to Seal Hydraulic Fracturing Boreholes in the Large-Size HDR Rocks under HTHP Conditions
Authors: Hongwei Zhang , Zhijun Wan , Zhao Yixin , Changbing Zhou , Chuanqi Zhu , Shuaifeng Lu 
Published: September 2021

Abstract
The hydraulic fracturing (HF) is a key technique to enhance the permeability and heat production of hot-dry-rock (HDR) geothermal reservoirs. Normally, laboratory HF tests should be preconducted to understand the HF characteristics of HDR samples. However, in the laboratory test, sealing failure between boreholes and injection pipes always limits the experimental efficiency and data accuracy, especially for the HF tests under high-temperature and high-pressure (HTHP) conditions. Traditional sealing methods, such as rubber and cement sealing, are easy to be failed because of their poor load and/or thermal bear performance under HTHP conditions. Therefore, in this study, we proposed a novel HTHP seal by using wedge-buckled copper components and steel rings. The sealing efficiency was verified by successfully conducting the HF tests of HDR rocks with a dimension of φ200×400 mm under various high temperatures ranging from 100°C to 400°C. As expected, the unfavorable factors such as HTHP and high injection pressure could be turned into favorable ones during the introduced seal method. By this investigation, we expect to provide some sealing solutions for researchers when conducting HF tests under HTHP environments.
Oligocene Planktic Foraminiferal Taxonomy and Evolution: An Illustrated Revision of Ocean Drilling Program Site 803
Authors: Fraass Andrew J. , Leckie R. Mark 
Published: September 2021

ABSTRACT
The Oligocene (33.9–23.0 Ma) has historically proven to be a difficult interval to examine with respect to planktic foraminifera; the tendency for many of the taxa to be basically globigerine in shape, with 4 or 5 chambers in the final whorl means differences between species are limited. Recently, an international working group has attempted to clarify the Oligocene planktic foraminiferal taxonomy, with the goal of establishing phylogenetically-consistent generic and species concepts. A relatively expanded and continuous Oligocene section recovered at Ocean Drilling Program Site 803 in the western equatorial Pacific was previously studied by Leckie et al. (1993) using fairly conservative species concepts. Since 1993, foraminiferal biostratigraphic datum age calibrations have changed, and so revised sedimentation rates for the 220-m thick Oligocene sequence are actually more constant than previously thought. As a part of the recent taxonomic revision, this site was reevaluated and numerous additional taxa are recorded at this location. Macroevolutionary rates are calculated from the occurrences, and increased extinction is found within the late Oligocene, counter to the expectations laid out in broader-scale macroevolutionary studies. An effort is made here to describe the diagnostic features, which can be used to distinguish all taxa under a standard binocular microscope. Finally, several figures of scanning electron microscope photomicrographs (from Site 803 and tropical Atlantic Ocean ODP Site 628) depict features used to describe and differentiate important, but difficult or homeomorphic taxa, with the hope that these figures can be used by other workers at the microscope attempting to do Oligocene taxonomy-based studies.
Growth and Fecundity of Marginopora Vertebralis and Amphistegina Lobifera in Laboratory Culture
Authors: Naidu Roselyn , Ford Murray , Kench Paul , Hallock Pamela , Prasad Rajesh 
Published: September 2021

ABSTRACT
The shells of large benthic foraminifers (LBF) are key contributors to the development and maintenance of coastal landforms in the Pacific as well as to Paleogene and Miocene carbonates deposited along the Neotethys Seaway and tropical Pacific islands. The current study assessed growth and fecundity of two species, Marginopora vertebralis and Amphistegina lobifera, collected from sites in Viti Levu, Fiji, based on shell diameter, shell weight, fecundity, and survival. Specimens were cultured without supplemental nutrients or food for 15 months under controlled laboratory conditions. Physicochemical parameters, including salinity, alkalinity, pH, and temperature, varied by &lt;5% throughout the experiment. Asexual reproduction by M. vertebralis produced ∼270 offspring per brood, while A. lobifera produced ∼500 offspring per brood. The minimum size at reproduction for M. vertebralis was 15 mm, and A. lobifera reproduction occurred at diameters ≥0.9 mm. These observations were consistent with those of previous studies that predicted asexual fecundity related to parent size. Four non-linear mathematical functions (exponential, Gompertz, logistic, and von Bertalanffy) were compared to describe the age-weight relationship for each species. Results revealed that the logistic model best fits M. vertebralis growth, and von Bertalanffy model best fits A. lobifera growth. The growth model for A. lobifera predicted trends in juvenile growth and maximum size consistent with a previously published von Bertalanffy model based on cultures in which the foraminifers were provided nutrient sources and grew much faster than those observed in this study. These observations support published hypotheses that many LBF are exceptionally well-adapted to extreme oligotrophy, a characteristic that accounted for their dominance as carbonate producers in the Paleogene and Miocene of the Neotethys and Pacific islands.
COOPERAÇÃO INTERORGANIZACIONAL
Authors: Frias Rafael Pena Cerqueira , Siqueira Rafaela da Costa , Xavier Filho José Lindenberg Julião , Fernandes Nelson Monteiro 
Published: September 2021

Este estudo se propôs a investigar as contribuições dos Acordos de Cooperação Técnica Interorganizacionais para o alcance da Missão de uma Instituição Federal de Ensino situada no Agreste de Pernambuco. Foram realizadas entrevistas e mapeamento de documentos que culminaram num conjunto de 8 (oito) Termos de Acordos de Cooperação Técnica analisados. Constataram-se proposições de contribuições ao cumprimento da Missão nas áreas de Ensino, Extensão e Pesquisa, através do compartilhamento/redução de custos, compartilhamento de experiências, poder de mercado, acesso a soluções e capital social. O estudo fornece informações úteis à gestão das Instituições Federais de Ensino, além de alavancar novas pesquisas no campo das experiências colaborativas.

Palavras-Chave: Acordos de Cooperação Técnica; Missão; Instituições Federais de Ensino; Apoio a Gestão; Experiências colaborativas.
WITHDRAWN: IL-31, IL-32 and IL-33 May Serve as Diagnosis Biomarkers in Gastric Cancer
Authors: Liu Qinghua , Zhang Jiwei , Xia Lei , Wise Steven G , Hambly Brett D. , Tao Kun , Bao Shisan 
Published: September 2021

Abstract
To determine whether IL-31, IL-32 and IL-33 can be used as biomarkers for the detection of gastric cancer (GC), via evaluating the correlations between IL-31, IL-32 and IL‑33 expression and clinicopathological parameters of GC patients. Tissue array (n=180) gastric specimens were utilised. IL-31, IL-32 and IL-33 in GC and non-GC tissues were detected immunohistochemically. The correlations between IL-31, IL-32 and IL-33 in GC and severity of clinicopathological parameters were evaluated. Survival curves were plotted using the Kaplan-Meier/Cox regression. IL-31, IL-32 and IL-33 in circulation were detected by ELISA. We found that IL-31, IL-32 and IL-33 were all lower in GC than that in adjacent non-GC gastric tissue (p all <0.05). IL-33 in peripheral blood of GC patients was significantly lower than that of healthy individuals (1.50 ± 1.11 vs 9.61 ± 8.00 ng/ml) (p<0.05). Decreased IL-31, IL-32 and IL-33 in GC were observed in younger patients (<60 years), and IL-32 and IL-33 were lower in female patients (p all <0.05). Higher IL-32 correlated with longer survival in two GC subgroups: T4 invasion depth and TNM I-II stage. Univariate/multivariate analysis revealed that IL-32 is an independent prognostic factor for GC within the T4 stage subgroup. Circulation IL-33 was significantly lower in GC patients than healthy people (p <0.05). Our findings provide new insights into the roles of IL-31, IL-32 and IL-33 in carcinogenesis of GC and demonstrate their relative usefulness as prognostic markers for GC. The underlying mechanism of IL-31, IL-32 and IL-33 in GC is further discussed.
Transcriptomic and Histological Analysis of Exposed Facial Skin Areas Wrinkled or Not and Unexposed Skin
Authors: Martin Renan , Varela Patricia , Gomes Caio Peres , Marins Maryana Mara , Filippelli-Silva Rafael , Yarak Samira , Soares Juliana L.M. , Sanudo Adriana , Idkowiak-Baldys Jolanta , Chen Siming , Hwang Cheng , Zhuang Yong , Lyga John , Pesquero João Bosco , Bagatin Ediléia 
Published: September 2021

Abstract
Skin aging involves genetic, environmental and hormonal factors. Facial wrinkles also depend on muscular activity. Gene expression investigation may be useful for new anti-aging products. To evaluate structure and gene expression differences among exposed and unexposed skin in menopausal women. Cross-sectional study, including 15 menopausal women, 55-65yo, phototype III; photo-exposed, periorbital wrinkles (A1), preauricular, not wrinkled (A2), and unexposed gluteal (A3) areas were described and compared by non-invasive measures, histology, immunohistochemistry and gene expression (RNASeq); participants mean age was 61yo, presenting moderate periorbital wrinkles and light facial photodamage. Higher roughness, wrinkles number and echogenicity were observed in A1 and A2 versus A3. Decreased epidermal thickness and dermal collagen IV were demonstrated in A1 versus A2 and A3. Exposed areas impacted different pathways compared to unexposed. Exposed wrinkled skin (A1) showed impact on cell movement with decreased inflammatory activation state. Pathways related to lipid and aminoacids metabolism were modulated in non-wrinkled exposed (A2) compared to unexposed (A3) skin. Expected histological findings and gene expression differences among areas were observed. Photoaging in menopausal women may modulate lipid and aminoacids metabolism and decrease inflammatory and keratinization pathways, cellular homeostasis, immune response, fibrogenesis and filament formation. These findings may help development of new therapies for skin health and aging control.