bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Chronic Kidney Disease on 5-Year Follow-Up Clinical Outcomes After Off-pump Coronary Artery Bypass Grafting-A Retrospective Study
Authors: Li Xihui , Zhang Siyu , Xiao Feng 
Published: January 2021

Abstract
BackgroudTo investigate the effect of chronic kidney disease (CKD) on mid- and long-term clinical outcomes after off-pump coronary artery bypass grafting (CABG).MethodsThis was a retrospective analysis of data of1141 discharged patients from January 2010 to June 2018 after undergoing off-pump CABG. Follow-up endpoints included stroke, myocardial infarction, heart failure, revascularization, and all-cause death.Patients with preoperative estimated glomerular filtration rate calculated, using the Chronic Kidney Disease Epidemiology equation of≥ 60 mL/min/1.73 m2 and < 60 mL/min/1.73m2, were assigned tonormal Group (1, 910 cases) and CKD group (231 cases), respectively. The effects of CKD on selected endpoint events were compared and analyzed.ResultsThere was a higher proportion of women, more preoperative complications, and a higher incidence of early postoperative complications in patients with CKD than inthose with normal renal function.After 1–9 years of follow-up (mean5.0±2.2 years), the incidences of stroke, myocardial infarction, and all-cause mortality were significantly higher in the CKD than in the normal renal function group, whereas incidences of revascularization and heart failure were not.Logistic regression analysis showed that preoperative CKD was a risk factor for stroke, myocardial infarction, and all-cause death during follow-up. After correctingfor common confounding factors, such as sex, age, and left ventricular ejection fraction, preoperative CKD was a risk factor for myocardial infarction and all-cause death.ConclusionsIn patientsundergoing off-pump CABG, preoperative CKD is associated with increases in the incidences of myocardial infarction and all-cause mortality 5-year postoperation..
Investigating the Effect of Positive, Intermediate and Negative Enabling and Training Factors Affecting Physical Activity in Pregnant Women
Authors: Kianfard Leila , SHokravi Farkhonde Amin , Rakhshanderou Sakineh , Niknami Shamsaddin 
Published: January 2021

Abstract
BackgroundPhysical activity during pregnancy period is one of the issues with priority during pregnancy period. Researches show that women reduce their physical activity during this period and are unaware of the benefits on the health of the mother and embryology. Although researchers regarding physical activity during pregnancy have prepared many guidelines; it is not however clear why pregnant women do not perform physical activity and the effectiveness factors that facilitate the desired behavior. MethodsThe research population included all pregnant women aged 18 to 40 years with gestational age of 12-38 weeks referring to the healthcare centers in District 5 of Tehran Municipality, from 22 districts of the city who had eliminated their physical activity during pregnancy. Questionnaires of physical activity assessment questionnaire after educational intervention in pregnant women (PPAQ) and a questionnaire designed based on the results of the needs assessment and the dimensions of the PEN-3 model were used for assessment. This study is a Research Clinical Trial (RCT). Due to the nature, a quasi-experimental research design (pre-test, post-test) with the control group was used in this research. ResultsBased on the obtained results, the intervention based on E-learning has a significant effect of enabling factors to increase physical activity in pregnant women in the experimental group. In addition, the intervention based on E-learning has a significant effect on the training factors in order to increase physical activity in pregnant women in the experimental group. ConclusionBased on the research results, it can be said that there is a statistically significant difference between the experimental and control groups in the scores obtained from training factors in the pretest and the experimental group. Furthermore, it can be said that there is a statistically significant difference between the experimental and control groups in the scores obtained from the enabling factors in the pre-test and the experimental group.
The Expression of αvβ3 and Osteopontin in Articular Cartilage of Patients with Knee Osteoarthritis and Its Correlation with Disease Severity and Chondrosenescence
Authors: Cheng Chao , Tian Jian , Gao Shuguang , Zhou Zhihong , Yang Ruiqi , Xiao Kai , Guo Wei , Liu Li , Yang Hua , Zhang Fang-Jie 
Published: January 2021

Abstract
Background: Osteoarthritis(OA) is the most common joint pathological disease associated with aging,previous observations have revealed that both osteopontin (OPN) and αvβ3 integrin are expressed in chondrocytes and both could as the biomarker for the progression of knee OA .The research aimed to comprehend the expressions of OPN and αvβ3 integrin and the chondrocyte senescence levels in OA. Methods: 48 cartilage tissues from normal and knee OA patients were divided into four groups of normal,minor,moderate, severe lesions based on the Mankin score. Immunohistochemistry and western blot were used to determine the expresssions of αvβ3,OPN and SAβ-gal in articular cartilage,Then Spearman’s correlation was used to analyze the correlations between Mankin Scores and αvβ3, OPN and SAβ-gal. The pearson correlation analysis was used to analyze the correlation among the αvβ3, OPN and SAβ-gal. Results: The expression of OPN and αvβ3 and SAβ-gal in articular cartilage were explored. αvβ3, OPN and SAβ-gal proteins all elvated in OA cartilage, the correlation coefficient between the Mankin score and the average optical density value of αvβ3, OPN, SAβ-gal were r=0.60,r=0.75,r=0.87,respectively, all p＜0.001,the correlation between the average optical density value of αvβ3 and OPN was r=0.3191, p<0.05, the correlation between αvβ3 and SAβ-gal was r=0.4955, p<0.001 , the correlation between OPN and SAβ-gal was r=0.7821, p<0.001.Conclusion: the correlation between αvβ3 , OPN and SAβ-gal expression in articular cartilage might be important to the OA progression and pathogenesis. Nonetheless, more researches are needed to elucidate the exact contribution of αvβ3 , OPN and SAβ-gal in the degenerative process of OA.
Effects of Prophylactic Antibiotic Administration and Antibiotic Timing on Culture Results and Clinical Outcomes of Pediatric Musculoskeletal Infection: A Protocol for A Randomized, Controlled, Clinical Trial
Authors: Xia Yongjie , Deng Chao , Zhou Yibiao , Wu Dechao , Liu Zhiyong , Xie Liangfu , E Bing , Han Jingming , You Chao 
Published: January 2021

Abstract
Background: Musculoskeletal infection (MSI) is a common cause of morbidity among the pediatric population. Some clinicians recommend withholding prophylactic antibiotics until culture collection with an aim to improve the culture sensitivity. However, a recent retrospective study reported that prophylactic antibiotic administration did not affect culture sensitivities in either disseminated or local MSI in pediatric population, which is surprising. Therefore, the aim of this study is to investigate the effects of prophylactic antibiotic administration and the timing of antibiotic administration on culture sensitivity and clinical outcomes of pediatric MSI.Methods: A randomized, controlled, clinical trial will be carried out. Individuals aged 0 to 18 years with a diagnosis of MSI will be screened and evaluated at the Shenzhen Children’s Hospital. The participants will be randomly allocated into four groups, and they will receive the antibiotic treatment at different time points, that is, 1 week, 3 days, 1 day prior to culture collection and 1 day after culture collection, respectively. The primary outcome will be culture sensitivity. In addition, the disease-related markers including white blood cell count (WBC), C-reactive protein (CRP), erythrocyte sedimentation rate, vital signs as well as the length of hospital stay will be measured or recorded accordingly. Using chi-squared tests, the rates of positive cultures will be compared between different groups. Statistical comparisons between the different patient groups regarding the confounding and outcome variables will be conducted using independent t-tests, Mann-Whitney U tests, chi-squared tests and Fisher’s exact tests as appropriate with the significance level set to 5% (P<0.05).Discussion: The results of this study would provide some evidence for the clinical management of pediatric MSIs with regards to the application of prophylactic antibiotics.Trial registration: Chinese Clinical Trial Registry, ChiCTR2100041631. Registered at 1 January 2021, http://www.chictr.org.cn/hvshowproject.aspx?id=69850.
Magnitude and Associated Factors of Virological Failure Among Children on ART in Bahir Dar Town Public Health Facilities, Northwest Ethiopia: a Facility Based Cross-sectional Study
Authors: Gelaw Belete , Mulatu Getasew , Tesfa Getasew , Marew Chalie , Chekole Bogale , Alebel Animut 
Published: January 2021

Abstract
Background: Despite the rapid scale-up of antiretroviral therapy, virologic failure has become global public health concern and challenge, especially in developing countries. Viral load monitoring is an important approach to identify treatment failure and develop public health interventions in children receiving antiretroviral therapy. Thus, this study aims to assess the magnitude and associated factors of virological failure among children on antiretroviral therapy. Methods: A facility-based cross-sectional study was conducted among 399 HIV-positive children on antiretroviral therapy from 2016 to 2019 in Bahir Dar Town public health facilities. Data were extracted from children’s charts using a standardized data extraction tool, adapted from ART intake and follow-up forms. Data were entered using Epi-Data Version 3.1, and analyzed using SPSS Version 25. Bivariable and multivariable binary logistic regression models were done to identify factors associated with virological failure. Variables with p-values < 0.25 were fitted into the multivariable analysis. Finally, variables with p-values ˂0.05 were considered as statistically significant factors.Results: The period prevalence of virological failure was found to be 14.8% (95% CI: 11.5-19.3%). Opportunistic infections (AOR=2.19, CI: 1.13-4.25), history of treatment interruption and restart (AOR=2.21, CI: 1.09-4.54), younger age (AOR= 2.42, CI: 1.02-5.74), poor/fair ART adherence (AOR=2.19, CI: 1.05-4.57), and advanced baseline WHO clinical staging (AOR= 2.32, CI: 1.14-4.74) were found to be factors significantly associated with virological failure.Conclusion: The magnitude of virological failure among HIV-infected children remained high. Children with poor/fair ART adherence, history of treatment interruption, advanced baseline WHO clinical staging, younger age, and opportunistic infections were significantly associated with virologic failure. Thus, special attention should be given to children who had poor/fair ART adherence and presenting with opportunistic infections.
Knowledge, Attitude, and Practice of Exclusive Breastfeeding Among Mothers Attending Masaka District Hospital Kigali/Rwanda: a Cross-section Study.
Authors: Luo Jiayou , Prince Dukuzumuremyi Claude Jean , Mungai Kaburu Francis , James Ntambara 
Published: January 2021

Abstract
Background: Exclusive breastfeeding (EBF) for 6 months is considered a major public health intervention to reduce the escalating child mortality of neonates and infants in low and middle-income countries. In most East Africa countries, exclusive breastfeeding did not meet the recommendation of WHO/UNICEF that a baby should be fed only breast milk for the first 6 months. This study is aimed to provide knowledge, attitudes, and practice (KAP) towards EBF and identify factors associated with the practice of exclusive breastfeeding. Methods: A cross-sectional study was conducted from January to April 2020. A total of 364 mothers were interviewed using a questionnaire. Univariate statistical analysis was used to define variables using frequencies and percentages. Multiple logistic regression was also applied to identify the factors associated with EBF practice.Results: In the current study, the majority of mothers, 84%, presented good knowledge, 87.0% also showed a good attitude toward EBF. Nearly 95.9% of the respondents understood the benefits of EBF practice for at least six months, 86.0% also responded that breast milk should be started immediately after birth within an hour. Besides, 87.6% knew the importance of the first breast milk or colostrum. 92.3% of mothers understand that breastfeeding increases mother-infant bonding, 92.3% of mothers understand that breastfed babies are healthier than formula-fed babies, and 94.8% believed that breast milk is the ideal food for babies. Furthermore, 76.4% of the surveyed mothers exclusively breastfed their infants for the first 6 months after delivery A married women (OR=.270; 95%CI=.160-.457, p<.001), had a high school degree(OR= .150; 95CI=.073-.307; p<.001), mothers whose had babies more than three (OR=.090; 95%CI=.035-.233, p<.001), good knowledge score(OR=2.535; 95%CI=1.399-4.594, P=0.002) and positive attitude score OR=2.051; 95%CI=1.149-3.662, P=0.015) were statistically significant association with EBF.Conclusion: In the studied area; knowledge and attitude of mothers towards EBF are relatively high. However, the level of EBF is still below the WHO recommendation. The findings of this study highly inform policymakers and healthcare providers to direct their efforts to provide evidence-based information and recommendations on the benefits of breastfeeding to promote the practice of exclusive breastfeeding.
Over half of clinical practice guidelines use non-systematic methods to inform recommendations: A methods study
Authors: Lunny Carole , Ramasubbu Cynthia , Puil Lorri , Gerrish Savannah , Liu Tracy , Salzwedel Douglas M. , Mintzes Barbara , Wright James M. 
Published: January 2021

Abstract
Introduction Assessing the process used to synthesise the evidence in clinical practice guidelines (CPGs) enables users to determine the trustworthiness of the recommendations. We aimed to assess whether systematic methods were used when synthesizing the evidence for CPGs; and whether reviews or ‘overviews of reviews’ were cited in support of recommendations.Methods and analysis We followed a study protocol. CPGs published in 2017 and 2018 were retrieved from TRIP and Epistemonikos. We randomly sorted and sequentially screened the CPGs to select the first 50 that met our inclusion criteria. Our primary outcomes were the numbers and proportions of recommendations that were based on reviews and ‘overviews‘, and CPGs using either a systematic or non-systematic process to gather, assess, and synthesise evidence. We also looked for evidence that critical appraisal was conducted. We also performed a chi-square test of independence to examine the relationship between variables. Results Of the 50 guidelines, 34% did an exceptional job in systematically synthesising the evidence to inform recommendations. These guidelines clearly reported their objectives and eligibility criteria, conducted comprehensive search strategies, and assessed the quality of the studies. 66% of CPGs reported non-systematic methods to develop their recommendations. This percentage is likely an underestimation because we excluded some CPGs when selecting studies. Overall, 90% of CPGs cited reviews to inform recommendations, and one fifth cited a Cochrane systematic review. Of the 29 CPGs that included reviews, 21% critically appraised the review. 60% of CPGs assessed the quality of primary studies. Conclusions We used novel methodology to evaluate recommendations in a random sample of CPGs, and found that 62% did not use a systematic process to gather, appraise, and synthesise the evidence. Significant improvement is needed in the conduct and reporting of CPG methods. Guideline developers should use systematic methods endorsed by reputable evidence synthesis organisations.
Interleukin-35 inhibited production of histamine and pro-inflammatory cytokines through suppression MAPKs pathway in HMC-1 cells
Authors: Fu Lixin , Chen Tao , Sun Qiaomei , Zhou Peimei , Guo Zai-pei 
Published: January 2021

Abstract
Background: IL-35 is a newly anti-inflammatory cytokine which belong to the IL-12 family. Mast cells, as one of the major effector cells in the immune response system, play important roles in the pathogenesis of chronic spontaneous urticarial (CSU). The aim of our study is to explore the inhibited role of IL-35 in HMC-1.Methods: The effects of IL-35 on cell proliferation, cytokine expression and histamine release in human mast cell line (HMC­1) were investigated by CCK8, ELISA or RT-PCR. The phosphorylation of ERK1/2, p38 and JNK1/2, in PMA and A23187 induced HMC-1 cells were detected by Western Blot.Results: We found that IL-35 significantly inhibited the proliferation of HMC-1 cells stimulated by PMA and A23187. IL-35 also down-regulates the released of histamine and the mRNA expression of IL-6 and IL-17 in activated HMC-1. Furthermore, IL-35 markedly inhibited the phosphorylation of ERK1/2, p38 and JNK1/2, in PMA and A23187 induced HMC-1 cells.Conclusions: This study provides first observations on the inhibitory and anti-inflammtory effect of IL-35 on activated HMC-1 cells. We suggest that IL35 may play an inhibited role in the pathogenesis of CSU.
SnpRecode: A Versatile and Fast Genotype Recoding and Correlation Function
Authors: Marete Andrew , Bissonnette Nathalie 
Published: January 2021

Abstract
Genotype imputation is an essential tool used in genomic selection in plants and animals. A popular imputation tool used in animal genomics is FImpute. FImpute, however, accepts a specific genotype format and produces dosages whose conversion to VCF or Plink format requires multiple software packages in a pipeline with a large amount of processing time. We have developed SnpRecode as a helper tool that bridges the gap between regular genotype files and the FImpute imputation software by allowing for fast and seamless conversion of genotypes to-and-from FImpute format. SnpRecode also implements a fast genotype correlation function to estimate and plot the imputation accuracy. We run tests on 6,000 samples with a step of 1,000 to determine the performance of SnpRecode on various sample sizes and runtime and memory usage used as performance measures. The performance of SnpRecode was modest at 10sec/1,000 samples. Written in Python programming language, SnpRecode provides users with great flexibility in implementation with other software packages in a pipeline.
Elevation-dependent compensation effects in snowmelt in the Rhine River Basin upstream gauge Basel
Authors: Rottler Erwin , Vormoor Klaus , Francke Till , Warscher Michael , Strasser Ulrich , Bronstert Axel 
Published: January 2021

Abstract
In snow-dominated river basins, floods often occur during early summer, when snowmelt-induced runoff superimposes with rainfall-induced runoff. An earlier onset of seasonal snowmelt as a consequence of a warming climate is often expected to shift snowmelt contribution to river runoff and potential flooding to an earlier date. Against this background, we assess the impact of rising temperatures on seasonal snowpacks and quantify changes in timing, magnitude and elevation of snowmelt. We analyse in situ snow measurements, conduct snow simulations and examine changes in river runoff at key gauging stations. With regard to snowmelt, we detect a threefold effect of rising temperatures: snowmelt becomes weaker, occurs earlier and forms at higher elevations. Due to the wide range of elevations in the catchment, snowmelt does not occur simultaneously at all elevations. Results indicate that elevation bands melt together in blocks. We hypothesise that in a warmer world with similar sequences of weather conditions, snowmelt is moved upward to higher elevation. The movement upward the elevation range makes snowmelt in individual elevation bands occur earlier, although the timing of the snowmelt-induced runoff stays the same. Meltwater from higher elevations, at least partly, replaces meltwater from elevations below.
Optimization of water productivity in Bhagwanpur distributary command of India employing TLBO and cuckoo search algorithms
Authors: Upadhyaya Ashruti , Upadhyaya Ashutosh 
Published: January 2021

Abstract
Efficient and judicious use of land and water is the need of the hour. In other words, evolving a cropping pattern, which optimizes productivity or net return considering prevailing constraints is quite useful to farmers, because such a cropping pattern is expected to be better than the existing cropping pattern in terms of yielding optimum productivity or net return. A single objective problem consisting of an objective function of optimization of water productivity with prevailing constraints was formulated and three optimization algorithms, namely (i) LINPROG, (ii) teaching learning based optimization (TLBO) and (iii) cuckoo search (CS) were employed to compute optimum water productivity corresponding to various affinity levels. It was observed that all three approaches yielded exactly the same values of water productivity at different affinity levels. TLBO showed better convergence capability as it reached the optimum value of objective function at a lower number of iterations than CS technique. Optimum water productivity at 20% affinity level seems quite practical and reasonable to be recommended in this distributary command for adoption because water productivity value is 2.57 times higher with 98.25 ha less cropped area as compared to the value of water productivity for the existing cropping pattern.
Modified DRASTIC model for groundwater vulnerability to nitrate contamination in the Dagujia river basin, China
Authors: Wei Aihua , Bi Pan , Guo Jie , Lu Shuai , Li Duo 
Published: January 2021

Abstract
Due to rapid economic growth and over-exploitation of groundwater, nitrate pollution in groundwater has become very serious. The main objective of this study is to modify the DRASTIC model to identify groundwater vulnerability to nitrate pollution. The DRASTIC model was firstly used to analyze the intrinsic vulnerability. The DRASTIC model with the inclusion of a land-use factor (DRASTIC-LU) was put forward to map the specific vulnerability of groundwater. Furthermore, the support vector machine (SVM) was introduced to avoid the drawback of the overlay and index methods, and the improved integrated models of DRASTIC + SVM and DRASTIC-LU + SVM were built. Moreover, 103 groundwater samples were collected for building and validating the models. The Root Mean Squared Error (RMSE) of DRASTIC, DRASTIC-LU, DRASTIC + SVM, and DRASTIC-LU + SVM was found to be 0.853, 0.755, 0.631, and 0.502, respectively. The model DRASTIC-LU was more precise than the original one. The results also showed that the integrated model using SVM exhibited better correlation between the vulnerability value and the nitrate pollution. The study indicated that the modified models including the land-use factor as well as SVM in the DRASTIC model were more suitable to assess the groundwater vulnerability to nitrate.