bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abdominal pregnancy-a case report
Authors: Roy Indrani , Choubey Neha 
Published: August 2021

Abdominal pregnancy is a rare obstetric complication with high maternal mortality and even higher perinatal mortality, and it can be primary or secondary with the latter being the most common type. This is a case of abdominal pregnancy in gravida 2, para 0+1 women admitted to the hospital with h/o amenorrhoea for two and a half months, with the chief complaints of pain abdomen for one week which was severe that day for which she attended emergency. Ultrasonography revealed a single live intra uterine pregnancy with a solid retro gestational sac collection, with a CRL of 11W3D. She was initially managed conservatively. Surgical intervention became necessary on day 9th when with the rising fundal height and drop in Hb levels, under general anaesthesia.
Giant chorioangioma with severe polyhydramnios presenting with abruptio placenta: a case report
Authors: Mudanur Subashchandra R. , Kori Shreedevi D. , Yaliwal Rajasri G. , Malapure Preeti S. 
Published: August 2021

Chorioangioma is the most common non trophoblastic tumor of the placenta which can result in pregnancy complications with attendant maternal and fetal mortality and morbidity.Although majority of them are asymptomatic, clinical course depends mainly on the size of the neoplasm.We present a case of large symptomatic placental chorioangioma managed successfully at Shri B M Patil Medical College,Vijayapura.The patient presented with acute features of abruptio placenta secondary to sudden decompression of uterus with polyhydramnios associated with large placental capillary chorioangioma of 10 cm size.Immediate intervention with Emergency LSCS helped rescue the baby of Intauterine demise and possible hemorrhagic morbidity in the mother.Further gross and histological examination confirmed the diagnosis.
Evaluation of the results of bioelectrical impedance analysis in patients undergoing laparoscopic sleeve gastrectomy and its effect on postoperative follow-up
Authors: ÖZDEN Hüseyin , ERBESLER Zeynel Abidin , ULCAY Tufan 
Published: August 2021

Aim: Obesity is a health problem. Laparoscopic sleeve gastrectomy (LSG) surgery is the most widely used surgical method in the treatment of obesity. Post-LSG follow-up is as important as the surgery itself. This study aims to examine the most accurate way to follow in the postoperative follow-up of LSG by examining the changes in body compositions such as fat and muscle.
Material and Method: 19 female patients who underwent LSG surgery by a single surgeon in Kırşehir Training and Research Hospital between September 2019 and March 2020 were included in our study. The mean age of the patients was 35.73 years. The mean body mass index (BMI) was 43.03. Bioelectric impedance analysis was performed on the patients before the surgery, at the 1st and 2nd months after the surgery. Statistical evaluation of the results was performed.
Results: Many undesirable values such as weight, BMI, and fat were significantly reduced (p
Tranexamic Acid Was Not Associated with Increased Complications in High-Risk Patients with Hip Fracture Undergoing Arthroplasty
Authors: Porter Steven B. , Spaulding Aaron C. , Duncan Christopher M. , Wilke Benjamin K. , Pagnano Mark W. , Abdel Matthew P. 
Published: August 2021

Background:
Tranexamic acid (TXA) is considered safe and efficacious for elective total joint arthroplasty. However, evidence of TXA’s safety in high-risk patients with hip fracture requiring nonelective arthroplasty has been lacking. This study aimed to assess whether TXA administration to high-risk patients with a hip fracture requiring arthroplasty increased the risk of thrombotic complications or mortality.

Methods:
All patients who underwent hip hemiarthroplasty (HHA) or total hip arthroplasty (THA) for displaced femoral neck fractures between 2011 and 2019 at 4 sites within 1 hospital system were retrospectively identified. Patients were grouped by risk (high-risk or low-risk) and TXA treatment (with or without TXA). Propensity scores were used for risk adjustment in comparisons between surgery with and without TXA for only the high-risk group (n = 1,066) and the entire population (n = 2,166). Differences in the occurrence of postoperative mortality, deep venous thrombosis, pulmonary embolism, myocardial infarction, and stroke within 90 days of hip arthroplasty were evaluated.

Results:
TXA administration was not associated with an increased risk of thrombotic complications or mortality within 90 days in either high-risk or all-patient groups. Specifically, among 1,066 matched high-risk patients who did not or did receive TXA, there were no significant differences in mortality (14.82% and 10.00%; p = 0.295), deep venous thrombosis (3.56% and 3.04%; p = 0.440), pulmonary embolism (2.44% and 1.96%; p = 0.374), myocardial infarction (3.38% and 2.14%; p = 0.704), or stroke (4.32% and 5.71%; p = 0.225).

Conclusions:
In our review of 1,066 propensity-matched high-risk patients undergoing hip arthroplasty for displaced femoral neck fractures, we found that TXA administration (compared with no TXA administration) was not associated with an increased risk of mortality, deep venous thrombosis, pulmonary embolism, myocardial infarction, or stroke.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Complex Shoulder Girdle Stabilization Using Allograft Capsular Reconstruction and Pectoralis Major Transfer
Authors: Lo Eddie Y. , Melton Christopher , Rizkalla James , Majekodunmi Temilola , Krishnan Sumant G. 
Published: August 2021

Case:
A 21-year-old woman with a history of multiple failed surgical and conservative management for recurrent involuntary shoulder instability presented with 1-year history of shoulder pain. Physical examination demonstrated intractable static anterior glenohumeral instability, deficient capsular tissue, with reducible scapular winging secondary to long thoracic nerve palsy. Allograft capsular reconstruction and open split pectoralis major tendon transfer were performed to salvage shoulder motion and stabilize her shoulder girdle.

Conclusion:
This report presents a novel repair option for intractable shoulder instability and scapular winging. Surgeons should recognize potential causes of shoulder instability and familiarize themselves with multiple stabilization techniques as potential salvage options before glenohumeral fusion.
Multiple Lesion Matrix–Induced Chondrocyte Implantation Procedure in a Collegiate Football Athlete
Authors: Gupton Marco , Romanelli Daniel , Johnson Jordan , Meyer Ben 
Published: August 2021

Case:
A 21-year-old male division I collegiate athlete presented for right knee pain, effusion, and mechanical symptoms. The patient was found to have 2.4 × 2-cm medial patellar facet, 1 × 0.8-cm central trochlea, and 2.5 × 3-cm lateral femoral condyle articular cartilage defects on arthroscopy. The patient was treated with a matrix-induced autologous chondrocyte implantation (MACI) procedure for all 3 lesions. At 9 months postoperatively, the patient returned to full American football activities and remains asymptomatic 16 months postoperatively.

Conclusion:
Multiple lesions and lesions involving the patellofemoral joint can be treated with a MACI procedure with short-term promising results in high-demand athletes.
Late Flexor Entrapment in Neocortex After Pediatric Forearm Fracture
Authors: Zeng Francine , Jorgensen Anna , Chaudhry Sonia 
Published: August 2021

Case:
A pediatric patient sustained an open Monteggia-equivalent fracture treated operatively. Despite uneventful fracture healing, late-onset extrinsic flexor tightness of the index finger occurred. A neocortex developed about the torn ulnar periosteum, entrapping the index flexor digitorum profundus muscle belly. Despite being 5 years postinjury, motion was improved after proximal muscle release.

Conclusion:
Acute flexor entrapment is well-reported in forearm fractures; however, late-onset entrapment inside a neocortex is not. Although early recognition of restricted motion is ideal, even long-standing contractures may be amenable to improvement with appropriate treatment guided by the physical examination.
Acute Compartment Syndrome of the Upper Extremity in Acquired Hemophilia A
Authors: Inagaki Naoya , Udaka Jun , Nishiwaki Kaichi , Hattori Daiki , Hiramoto Yuki , Saito Mitsuru 
Published: August 2021

Case:
Acute compartment syndrome (ACS) with acquired hemophilia A (AHA) is rare and has no established treatment strategy. A 64-year-old woman presented with a giant hematoma in the rectus abdominis. Laboratory findings included decreased hemoglobin and increased activated partial thromboplastin time. Arterial embolization was performed for hemostasis. After catheter removal, she developed severe arm pain and numbness with blistering. Fasciotomy was performed to decrease intracompartmental pressure. Laboratory investigations revealed decreased factor VIII (FVIII) activity and increased FVIII inhibitor. AHA was diagnosed and treated with immunosuppressive and FVIII inhibitor-bypassing agents.

Conclusions:
Fasciotomy should be performed promptly if ACS with AHA is suspected.
Magnetically Controlled Growing Rods: Influence on Intraoperative Fluoroscopic Imaging
Authors: Sio Brenton , Pan Woei Jack , Lim Kevin Boon Leong 
Published: August 2021

Case:
A 7-year-old boy with severe congenital scoliosis and impending thoracic insufficiency syndrome underwent uneventful single magnetically controlled growing rod (MCGR) insertion and removal of his ipsilateral rib-based distraction implants at our institution. Intraoperative fluoroscopy imaging revealed an artifactual bend (S-distortion) of the rod actuator after placement. This artifact was eliminated by moving the image intensifier further from the patient.

Conclusion:
We attributed the S-distortion to influences of magnetic fields within the MCGR actuator onto the image intensifier. Surgeons should be aware of such implications which can lead to misleading imaging artifacts. This is a first reported case of such incident with MCGR.
Crustal-scale transport of nanoparticle emulsion forms ore deposits
Authors: Petrella Laura , Thebaud Nicolas , Fougerouse Denis , Martin Laure , Turner Stephen , Suvorova Alexandra , Gain Sarah 
Published: August 2021

Abstract
A 10- to 10 000-fold enrichment is required to form economic metal deposits. Such enrichment is achieved through the accumulation of metals transported in hydrothermal fluids from their source to the deposit. The contribution of gold nanoparticle suspensions in fluids is required to form bonanza gold grades. However, as the source of gold is spatially disconnected from the deposit location, it is not known how the transport of gold nanoparticles is achieved. Here we show that metal nanoparticles (Au, AgO, AuAg Cu) are stabilised by colloidal silica in nanoparticle emulsion and transported with the aid of low-density carbonic phases. We document systematic occurrence of metals nanoparticle in five deposits that show a previously unrecognized association with amorphous silica and carbon. Our results demonstrate that stabilisation of metal nanoparticles may be achieved over kilometres through the Earth’s upper crust and offers a step change in our understanding of metalliferous deposit formation.
In vitro modeling for the aging of nanoplastics: physicochemical characteristics and effect on the biofilm formation of Staphylococcus aureus
Authors: Saygin Hasan , Baysal Aslı 
Published: August 2021

Abstract
Over the last decade, it has become clear that the pollution by plastic debris presents global societal, environmental, and human health challenges. Increasing scientific attention on the occurrence and influence of plastic particles, and their potential toxic effects on the environment are evident. However, humans are also exposed to plastics in daily life and very limited information is available concerning human health, especially aging process in biological fluids and the colonization of the bacteria on plastics due to transport the pathogens, causing the infectious is another vital problem. Moreover, various studies also observed the importance of the nano-sized particles since a lower size can increase the activity, surface area etc. Therefore, the aim of this study is to investigate the in vitro (artificial saliva, artificial lysosomal fluid, phagolysosomal simulant fluid, Gamble’s solution) aging of plastic particles and the effect on the formation of Staphylococcus aureus biofilms with nanoplastics under in vitro conditions. We found that the surface properties of the nano-sized plastic particles changed according to the surrounding environment and surface deformation and the surface affinity to the biological activity was triggered with in vitro conditions due to higher hydroxyl index and carbon to nitrogen ratio. The results also showed that the Staphylococcus aureus biofilms formed with nanoplastics with the aging in vitro conditions. However, their levels and characteristic of extracellular polymeric substances were varied in these conditions with aging compared to control, and more basophilic extracellular polymeric substances were formed with these conditions.
Using a Novel Change Detection Algorithm to Predict Daily Linear Accelerator Output Changes in a Radiation Department.
Authors: Ashburner Mark , Mugabe Koki , Mohanathas Yathu , Umar Ahmad , Huang David , Dobbie Gill 
Published: August 2021

Abstract
Machine learning tools and techniques were utilised to create a Novel Change Detection Algorithm (NCDA) as a supplementary quality assurance tool to alert users to potential significant changes in linear accelerator output using daily measurements. A prototype model was developed and validated that provides a forecast for the daily dose and indicated when there is the potential for the output to change beyond what is considered normal daily drift. The model provided a good fit with the validation dataset used, meaning that trends in daily output were easy to identify.The NCDA can be used either daily whereby output data is manually entered from the QA3 user interface, or on a weekly basis allowing input of the other data which is not traditionally presented on the interface. The NCDA should serve as a tool to alert users when data is trending out of tolerance and inform of possible output adjustments, therefore enabling effective allocation of time and resources.
DZNep Promotes Mouse Bone Defect Healing via Enhancing Both Osteogenesis and Osteoclastogenesis
Authors: Cao Xiankun , He Wenxin , Rong Kewei , Xu Shenggui , Chen Zhiqian , Liang Yuwei , Han Shuai , Zhou Yifan , Yang Xiao , Ma Hui , Qin An , Zhao Jie 
Published: August 2021

Abstract
Background: EZH2 (Enhancer of zeste homolog 2) is a novel oncogene that can specifically trimethylate the histone H3 lysine 27 (H3K27me3) to transcriptionally inhibit the expression of downstream tumor-suppressing genes. As a small molecular inhibitor of EZH2, 3-Deazaneplanocin (DZNep) has been widely studied due to the role of tumor suppression. With the roles of epigenetic regulation of bone cells emerged in past decades, the property and molecular mechanism of DZNep on enhancing osteogenesis had been reported and attracted a great deal of attention recently. this study aims to elucidate the role of DZNep on EZH2-H3K27me3 axis and downstream factors during both osteoclasts and osteoblasts formation and the therapeutic possibility of DZNep on bone defect healing.Methods: Bone marrow drived macrophages (BMMs) cells were cultured and their responsiveness to DZNep was evaluated by Cell Counting Kit-8, TRAP staining assay, Bone Resorption Assay, Podosome Actin Belt. Bone marrow drived mesenchymal stem cells (BMSC) were cultured and their responsiveness to DZNep was evaluated by Cell Counting Kit-8, ALP and AR staining assay. The expression of nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), Wnt signaling pathway was determined by qPCR and western blotting. Mouse bone defect models were created, rescued by DZNep injection and the effectiveness was evaluated by X-ray and Micro-CT and Histological staining.Results: Consistent with the previous study that DZNep enhances osteogenesis via Wnt family member 1(Wnt1), Wnt6, and Wnt10a, our results showed that DZNep also promotes osteoblasts differentiation and mineralization through the EZH2-H3K27me3-Wnt4 axis. Furthermore, we identified that DZNep promoted the receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL)-induced osteoclast formation via facilitating the phosphorylation of IKKα/β, IκB, and subsequently NF-κB nuclear translocation, which credit to the EZH2-H3K27me3-Foxc1 axis. More importantly, the enhanced osteogenesis and osteoclastogenesis result in accelerated mice bone defect healing in vivo.Conclusion: DZNep targeting EZH2-H3K27me3 axis facilitated the healing of mice bone defect via simultaneously enhancing osteoclastic bone resorption and promoting osteoblastic bone formation.
Characterization of Wnt Genes in Argopecten Scallops and Their Involvement in Responses to Different Temperature Stresses in Bohai Red Scallops
Authors: Wang Caihui , Chen Min , Liu Bo , Ning Junhao , Lu Xia , Zhang Jinsheng , Wang Chunde 
Published: August 2021

Abstract
Background: Bohai Red, a new Argopecten scallop strain selected from the hybrids between the Peruvian scallop, Argopecten purpuratus and the bay scallop northern subspecies, A. irradians irradians, is now one of the most cultured scallop strains in northern China. As one of a series of studies focusing on adaptation of Bohai Red scallops to fluctuations in environmental factors, this study aimed to examine the expression profile of Wnt genes in response to different temperature stresses in Bohai Red. Results: As Bohai Red scallops were originated from the hybrids between the Peruvian scallop and the bay scallop northern subspecies, we first identified all Wnt genes from the genomes of the Peruvian scallop and the bay scallop northern subspecies, as well as the bay scallop southern subspecies, A. i. concentricus. Twelve Wnt members were identified from the two subspecies of bay scallop, and 13 Wnt genes were found in the genome of the Peruvian scallop. Protein structure analyses showed that most Wnt genes poses all 5 conserved motifs except Wnt 1, Wnt 2, Wnt 6 and Wnt 9 in the bay scallops and Wnt2 and Wnt9 in the Peruvian scallop. Unexpectedly, Wnt8 gene was present while Wnt3 was absent in both the bay scallops and the Peruvian scallop. Phylogenetic analysis revealed that Wnt3 may have disappeared in the early evolution of mollusks. The expression profile of Wnt genes in Bohai Red exposed to different temperatures were examined by qRT-PCR. The results showed that expression of Wnt genes responded differentially to temperature changes. The Wnt genes such as Wnt1, Wnt6, Wnt7, Wnt11 and WntA that responded slowly to low and high temperature stresses may be related to the maintenance of basic homeostasis. Other Wnt genes such as Wnt4, Wnt9, Wnt5 and Wnt2 that responded rapidly to low temperature may play an important role in organismal protection against low temperature stress. And yet some Wnt genes including Wnt10, Wnt16, and Wnt8 that responded quickly to high temperature stress may play key roles in response to organismal stress provoked by high temperature stress. Conclusions: Wnt genes are well conserved in Argopecten scallops, as in other bivalves. Wnt genes may play important roles in adaptation of Bohai Red scallops to changing temperatures. The results in this study will provide new insights into the evolution and function of Wnt genes in bivalves and eventually benefit culture of Bohai Red scallops.
Interaction effects between variants in TOMM40 and PVRL2 with plasma amyloid-β and Alzheimer's disease among Chinese older adults: a population-based study
Authors: xiaoyan liang , Liu Cuicui , Liu Keke , Cong Lin , Wang Yongxiang , Liu Rui , Fa Wenxin , Tian Na , Cheng Yingzhe , Wang Nan , Hou Tingting , Du Yifeng , Qiu Chengxuan 
Published: August 2021

Abstract
Background

Emerging evidence has linked TOMM40 and PVRL2 polymorphisms with Alzheimer’s disease (AD). We examined their associations with AD and plasma AD biomarkers and interaction on AD risk among Chinese older adults.
Methods

This population-based study included 4876 participants (age ≥ 65 years, 57.2% women) from MIND-China. TOMM40(rs2075650) and PVRL2(rs6859) polymorphisms were detected using multiple-polymerase chain reaction amplification. Plasma Aβ40, Aβ42, and t-tau were measured using SIMOA in a subsample (n = 1257). Data was analyzed using multiple logistic and general linear regression models.
Results

AD was diagnosed in 182 participants. The multi-adjusted odds ratio of AD was 6.24(95%CI 1.73–22.48) for TOMM40GG (vs. AA), 1.47(0.89–2.42) for PVRL2AA (vs. GG), and 12.87(3.97–41.73) for having both risk alleles (Pinteraction=0.0003). In the plasma biomarker subsample, TOMM40GG was significantly associated with lower plasma Aβ42 and the Aβ42-to-Aβ40 ratio (p < 0.05).
Conclusions

TOMM40 and PVRL2 genes could interact to substantially increase the likelihood of AD, possibly through influencing Aβ metabolism.
Synthesis, Quantum Chemical Calculations, Molecular Docking and Studying the Effect of High Energetic Gamma Irradiation on Cu(I, II), Zn(II) and Cd(II) Complexes with their Antibacterial Activity.
Authors: Elganzory Hussein 
Published: August 2021

Abstract
New complexes of Cu(I,II), Zn(II) and Cd(II) of thiosemicarbazide ligand 1-(p-(methylanilinocetyl-4-phenyl-thiosemicarbazide)(H2LB) have been prepared and characterized by 1HNMR, Mass spectra, FT-IR, elemental analyses, molar conductance, UV-visible spectra, magnetic susceptibility measurements, thermogravimetric analysis (TGA/DTG) and X-ray diffraction pattern before and after irradiation. The results confirmed that gamma ray enhanced the stability of irradiated compounds as compared to non-irradiated compounds. XRD patterns proved that increasing the crystallinity of the samples and the particles in nano range after gamma irradiation. The obtained data indicated that the Cu(I) and Cd(II) ions coordinated to the ligand through the (C = O), N(2)H and (C = S), the ligand behaves as neutral tridentate. While in complexes Cu(II) and Zn(II)complexes (B2 and B3) the ligand behave as neutral tetradentate and coordination take place via (C = O) and two N(2)H. These studies revealed that, two kinds of stereochemical geometries; Cu(II) and Zn(II) complexes were predicted to be octahedral, Cu(I) and Cd(II)complexes were found to be tetrahedral. The theoretical conformational structure analyses were performed using density functional theory for ligand and complexes at B3LYP functional with 6-31G(++)d,p basis set for ligand and LANL2DZ basis set for complexes. The ligand and its metal complexes have been tested for their inhibitory effect on the growth of bacteria against gram-positive (Streptococcus pyogenes) and gram-negative (Escherichia coli). Results suggested that in case of 1µg/ml and 5µg/ml for Cu(II) and Zn(II) complexes have higher activity than other complexes. The chelation could facilitate the ability to cross the cell membrane of E. coli and can be explained by Tweedy’s chelation theory. Molecular docking investigation proved that; the Zn(II) complex had interesting interactions with active site amino acids of topoisomerase II DNA gyrase enzymes (code: 2XCT).