bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Early Fluid Overload and Mortality in Critically-ill Mechanically Ventilated Children: A Single Center Prospective Cohort Study
Authors: Kong Xiangmei , Zhu Xiaodong , Zhu Yueniu 
Published: May 2021

Abstract
Background: This study retrospectively analyzed the relationship between early fluid overload(FO) and in-hospital mortality in Children with mechanical ventilation in pediatric intensive care unit.Methods: Patients who were on mechanical ventilation (MV) for≥48 h and aged over 28 days and less than 18 years from March 2014 to March 2019 in department of PICU, Xinhua hospital. Daily FO was calculated as {(daily fluid intake-daily fluid output)/weight at ICU admission * 100%}.We defined the early FO as the FO in the first three days of mechanical ventilation, and divided it into four bands: %FO ≤ 0%, 0%＜%FO≤ 10%, 10%＜%FO≤ 20%, and %FO > 20%. We compared the mortality in discharge between groups with different FO. We also compared the early FO between survivors and non-survivors. Multivariate stepwise logistic regression analysis was used to analyze the prognostic factors of mortality in hospital.Results: 309 patients were included. There were 202 cases in non-operative and 107 cases in operative. The mean early FO was 8.83 ± 8.81%, and the mortality in hospital was 26.2% (81/309). The percentage of % FO＞10% was in present 41.4%(131/309) and %FO＞20% was in present 8.7% (27/309). There was no significant difference in discharge-mortality between different FO groups(p=0.053) and in FO between survivors and non-survivors(p=0.992). Regression analysis demonstrated that the more vasoactive drugs, the presence of MODS, the longer duration of MV, and the non-operation reason for PICU admission were related to the increase of mortality(p＜0.05); although early FO and %FO>10% were not associated with in-hospital mortality(β=0.030, p=0.090, 95% C.I.=0.995~1.067; β=0.479, p=0.153, 95% C.I.= 0.837~3.117), %FO>20% was related to the increase of mortality (β=1.057, OR=2.878, p=0.029, 95% C.I.=1.116~7.418). There was positive correlation between early FO and LOS in PICU (r=0.148, p=0.009), but the relation is weak.Conclusions: Affected by interventions and the severity of the disease, the correlation between the early FO and %FO>10% with mortality was not clear, but %FO>20% was related to the increase of mortality in critically-ill mechanically ventilated Children. Trial registration: Not applicable
CaV2O6: A highly effective sintering aid for 0.61CaTiO3-0.39LaAlO3 ceramics
Authors: Chen Zizu , Yang Han , Guo Rongdi , Wu Guohua , Qiu Yang , Zhu Mingmin , Yu Guoliang , Zhou Haomiao 
Published: May 2021

Abstract
The 0.61CaTiO3-0.39LaAlO3 (CTLA) ceramics are widely used in relay station, aerospace and radar systems for their superior properties: remarkable quality factor and excellent thermal stability. However, some deficiencies remain, such as low permittivity and excessively high sintering temperature, which limit their development in microwave communication. Herein, we introduce CaV2O6 to the CTLA ceramics to solve these problems and systematically investigate its effects on sintering temperature, phase constitution, microstructure and microwave dielectric properties. The CTLA ceramics added with 0–2.0 wt% CaV2O6 were prepared by the traditional solid-state reaction procedure. The XRD patterns indicated that the pure phase Ca0.61La0.39Al0.39Ti0.61O3 (PDF #52-1773) was obtained from all samples, which revealed that the CaV2O6 was dissolved into CTLA lattice to form a solid solution. As the CaV2O6 content increased, the strongest X-ray diffraction peaks gradually shifted toward low angles, which manifested the increase of cell volume of the solid solution. When the additive amount was 1.0 wt%, the CaV2O6 could high-effectively lower the sintering temperature from 1450 ℃ to 1290 ℃ and obviously promote the growth of grains. Meanwhile, the εr slightly increased, the Q×f significantly improved and the τf favorably decreased to closer to zero, then the prominent microwave dielectric performance was exhibited, with εr = 40.6, Q×f = 48,800 GHz (at 4.5 GHz), and τf = 0.78 ppm/℃. Such CTLA ceramics are expected to promote the development of high-performance and temperature-stable microwave components.
Resonance Y-type soliton, hybrid and quasi-periodic wave solutions of a generalized (2+1)-dimensional nonlinear wave equation
Authors: He Lingchao , Zhang Jianwen , Zhao Zhonglong 
Published: May 2021

Abstract
In this paper, we consider a generalized (2+1)-dimensional nonlinear wave equation. Based on the bilinear, the N-soliton solutions are obtained. The resonance Y-type soliton and the interaction solutions between M-resonance Y-type solitons and P-resonance Y-type solitons are constructed by adding some new constraints to the parameters of the N-soliton solutions. The new type of two-opening resonance Y-type soliton solutions are presented by choosing some appropriate parameters in 3-soliton solutions. The hybrid solutions consisting of resonance Y-type solitons, breathers and lumps are investigated. The trajectories of the lump waves before and after the collision with the Y-type solitons are analyzed from the perspective of mathematical mechanism. Furthermore, the multi-dimensional Riemann-theta function is employed to investigate the quasi-periodic wave solutions. The one-periodic and two-periodic wave solutions are obtained. The asymptotic properties are systematically analyzed, which establish the relations between the quasi-periodic wave solutions and the soliton solutions. The results may be helpful to provide some effective information to analyze the dynamical behaviors of solitons, fluid mechanics, shallow water waves and optical solitons.
Efficacy and Safety of Corticosteroid Use on Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis
Authors: Cui Yuqing , Sun Yali , Sun Junyi , Liang Huoyan , Ding Xianfei , Sun Xueyi , Wang Dong , Sun Tongwen 
Published: May 2021

Abstract
Background: We conducted a comprehensive literature review to synthesize evidence for the relationship between corticosteroid use and mortality in COVID-19 patients.Methods: The PUBMED, EMBASE, and Cochrane Library were searched from inception to March 13, 2021. We searched and analyzed randomized controlled trials (RCTs) and observational studies (OS) that examined the corticosteroid use in COVID-19 patients. The primary outcome was in-hospital mortality, while the secondary outcome was the need for mechanical ventilation (MV) and serious adverse events. Results: 11 RCTs and 46 OS involving 7,893 and 4,1696 COVID-19 patients were included in the study. Corticosteroid use was associated with lower COVID-19 mortality in RCTs, but was not statistically significant (OR, 0.88; 95% CI, 0.74–1.05; I2=66.9%). The subgroup analysis of severe COVID-19 patients, corticosteroid type and dose also showed no survival benefit statistically. However, the corticosteroid use may reduce the MV need (OR, 0.67; 95% CI, 0.51–0.90; I2=7.5%) with no significant increase in serious adverse reactions (OR, 0.84; 95% CI, 0.30–2.37; I2=33.3%). In addition, the included OS showed that the pulse dose (OR, 0.52; 95% CI, 0.39–0.70) and methylprednisolone use (OR, 0.69; 95% CI, 0.52–0.92; I2=66.7%) may lower the mortality in COVID-19 patients. Conclusions: This meta-analysis indicated that corticosteroid use might cause a slight reduction in COVID-19 mortality. However, it could significantly reduce the MV requirement in COVID-19 patients and restrict serious adverse events. Additionally, the pulse dose of methylprednisolone may be a good treatment choice for COVID-19 patients.
Factors Associated With the Antinuclear Antibody Titer of Patients With Systemic Autoimmune Rheumatic Diseases After Treatment: A Retrospective Study
Authors: Xiao Yun , Zhang Yan , Lin Yiqiang , Wang Jiajia , Zeng Yanli 
Published: May 2021

Abstract
Background: Antinuclear antibodies (ANAs) are a serological hallmark of systemic autoimmune rheumatic diseases (SARDs); however, few studies have investigated their post-treatment levels.Objective: The mechanism by which ANA titers are upregulated in SARDs remains unclear. We assessed factors associated with the ANA titer after treatment.Methods: In this retrospective study we analyzed the clinical database of Zhongshan Hospital, Medical College of Xiamen. Demographic data and baseline and 12-month post-treatment ANA titers were collected. Bivariate and multivariate analyses were performed to determine the factors associated with the ANA titer.Results: This study identified 31,923 patients who underwent ANA assay for SARDs screening, and a total of 1043 patients were included in the study. Approximately 16% of the patients showed a decrease in the serological ANA titer. Men were twice as likely to achieve a decrease in the serum ANA titer than women (P = 0.055), and younger patients (<20) were 3× more likely to experience such a decrease (P = 0.005) compared to older patients (≥60 years). A baseline ANA titer >1:10000 was associated with a significantly lower (47×) serum ANA titer compared with the baseline ANA titer at a dilution of 1:100 (P < 0.001).. Homogeneous (P = 0.095) and cytoplasmic speckled (P = 0.158) had over threefold greater decrease in the serum ANA titer compared with other patterns.Conclusion: We found that a decrease in the serum ANA titer at 12 months after treatment for SARDs is associated with age, sex, ANA baseline titers, and ANA pattern.
Rheumatological Diseases in Patients with Inborn Errors of Immunity in the USIDNET Registry
Authors: Padem Nurcicek , Wright Hannah , Fuleihan Ramsay , Garabedian Elizabeth , Suez Daniel , Cunningham-Rundles Charlotte , Marsh Rebecca , Khojah Amer 
Published: May 2021

Abstract
Purpose

There is a gap in clinical knowledge regarding associations between specific inborn errors of immunity (IEIs) and rheumatological diseases. In this study, we report the frequency of rheumatological conditions in a large cohort of patients with IEI using the USIDNET (United States Immunodeficiency Network) registry.
Methods

We used the USIDNET registry to conduct the analysis. We included all IEI patients within the registry for whom a diagnosed rheumatological disease was reported.
Results

The total number of patients with IEI in our query was 5058. Among those, 278 (5.49%) patients had a diagnosis of rheumatological disease. This cohort included 172 (61.8%) female and 106 (38.2%) male patients. Rheumatologic complications were highest in the interferonopathies (66.6%), autoimmune lymphoproliferative syndrome (ALPS) (13.7%) and Immunoglobulin G subclass deficiency (IgGSD) (11.11%). Additionally, disease patterns were noted to be different in various IEI disease groups. Inflammatory myopathies were the most common rheumatologic condition in patients with X-linked agammaglobulinemia (1.65%), Sjogren’s syndrome was the most common rheumatology disease reported in ALPS patients (6.85%) and systemic lupus erythematosus was the most common rheumatology disease in in patients with Chronic mucocutaneous candidiasis(CMC) (7.41%). Rheumatoid arthritis (RA) report rate was highest in patients with IgGSD (3.70%), specific antibody deficiency (3.66%), and ALPS (2.74%).
Conclusion

This study reports that rheumatologic diseases are frequently observed in patients with IEI. The frequency of different rheumatological disease was variable based on the underlying diagnosis. Clinicians caring for patients with IEI should be vigilant to monitor for rheumatologic complications.
Long Noncoding RNA SGO1-AS1 Inactivates TGFβ Signaling by Facilitating TGFB mRNA Decay and Inhibits Gastric Carcinoma Metastasis
Authors: Huang Donglan , Zhang Ke , Zheng Wenying , Zhang Ruixin , Chen Jiale , Du Nan , Xia Yuanyuan , Long Yan , Gu Yixue , Xu Jianhua , Deng Min 
Published: May 2021

Abstract
Background: Although thousands of long noncoding RNAs (lncRNAs) have been annotated, only a limited number of them have been characterized functionally. In this study, we aimed to identify novel lncRNAs involved in the progression of gastric carcinoma (GC) and explore their regulatory mechanisms and clinical significance in GC.Methods: LncRNA expression microarray was used to identify differential lncRNA expression profiles between paired GCs and adjacent normal mucosa tissues. Using the above method, lncRNA SGO1-AS1 was picked out for further study. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) and in situ hybridization (ISH) were performed to detect SGO1-AS1 expression in GC tissues. Gain-of-function and loss-of-function analyses were performed to investigate the functions of SGO1-AS1 and its upstream and downstream regulatory mechanisms in vitro and in vivo. Results: SGO1-AS1 was downregulated in gastric carcinoma tissues compared to adjacent normal tissues, and its downregulation was positively correlated with advanced clinical stage, metastasis status and poor patient prognosis. Functional experiments revealed that SGO1-AS1 inhibited GC cell invasion and metastasis in vitro and in vivo. Mechanistically, SGO1-AS1 facilitated TGFB1/2 mRNA decay by competitively binding the PTBP1 protein, which resulted in reduced TGFβ production and thus prevented the epithelial-to-mesenchymal transition (EMT) and metastasis. In addition, TGFβ in turn could inhibited SGO1-AS1 transcription by inducing ZEB1. Thus, SGO1-AS1 and TGFβ form a double-negative feedback loop via ZEB1 to regulate EMT and metastasis.Conclusions: SGO1-AS1 functions as an endogenous inhibitor of the TGFβ pathway and suppresses gastric carcinoma metastasis, indicating a novel potential target for GC treatment.
In-silico study of Hesperidin, Epigallocatechin (EGCG ), Kaempferol and Quercetin
Authors: Chatterjee Soham , Maiti Smrajit , Bannerjee Amrita , Kanwar Mehak 
Published: May 2021

Abstract
SARS-Cov-2 or COVID-19 has caused a global disaster and catastrophe which has consequently led to a pandemic for the last two decades, the world has faced coronaviruses similar to SARS-Cov-2 such as SARS-Cov and Mers-Cov. In this study, a wide range of proteins such as Plpro (Papain like Protease), Rdrp (RNA-Dependent-RNA-Polymerase), Mpro or 3cl Protease and Spike Protein. The selected proteins were listed retrieved from RCSB PDB(https://www.rcsb.org/) And Zhang lab (https://www.zhanglab.ccmb.med.umich.edu/COVID-19/) with their corresponding and respective PDB-ID. The 3d Structures or 2D Structures of these molecules were selected on the sole basis of resolved resolution (in Å)of the structures during the X-ray crystallography and Electron Microscopy. Structures were retrieved in .pdb format. The three dimensional ligand molecules were retrieved from PubChem chemical structure In Spatial Data Base (.SDF) format. The respective ligand molecules are; Hesperidin, Kaempferol, Quercetin, Epigallocatechin. This molecular docking shows significant data of polyphenols, flavonoids and bioflavonoids inhibiting SARS-Cov-2 proteins which could lead to conclusive data for treatment of polyphenols, flavonoids and bioflavonoids against SARS-Cov-2.
Gastrointestinal Stromal Tumor of the Small Bowel Complicated by Torsion: A Case Report
Authors: Jun-ichi Yoshizawa , Shimizu Tadaaki , Ikehara Tomohiko , Fukushima Kentaro , Nakayama Ataru 
Published: May 2021

Abstract
Background: Gastrointestinal stromal tumor (GIST) is a mesenchymal tumor originating in the wall of the gastrointestinal tract, and 20-30% of these tumors originate from the small intestine. The clinical manifestations of GIST of the small intestine generally include a palpable mass, distention, and abdominal pain and sometimes include acute abdomen due to ileus, bleeding, perforation, and intussusception at onset. Here, we describe a rare case of a pedunculated GIST of the small intestine complicated by torsion.Case presentation: A 69-year-old woman was referred for lower abdominal pain. Abdominal contrast-enhanced computed tomography showed a 73×62×57-mm tumor in the pelvic cavity with an enhanced margin and reduced contrast effect inside of it. T2-weighted magnetic resonance imaging showed a hyperintense, demarcated, lobulated tumor. The diffusion-weighted image showed hyperintensity, and the apparent diffusion coefficient value revealed diffusion restriction, indicating malignancy. T1-weighted images showed a low intensity tumor; contrast-enhanced images showed hypointensity inside of the tumor and slight hyperintensity around its edges. It was presumed that the tumor had caused hemorrhagic infarction. Emergency laparotomy was performed, and the pedunculated tumor was found to be twisted 360 degrees clockwise at the pedicle with hemorrhage and necrosis due to torsion. We performed partial resection of the small intestine including the tumor. Histopathology revealed tightly arranged spindle-shaped cells with hemorrhage, congestion, and inflammatory cell infiltration. Immunohistochemical staining showed positivity for CD34, CD117, and DOG1.Conclusions: The present report describes a very rare case in which pedicle torsion of an extra luminal expanding GIST of small intestine, although there were some reports of small intestine volvulus caused by GIST of small intestine as a rare condition. The torsion of pedunculated GIST of small intestine should be recognized as an emergency condition of GIST, and we report that characteristic findings of this condition were acquired with CT and MRI which was possibility useful for the diagnosis.
A Spatially Distributed Groundwater Metric for Describing Hydrologic Changes in a Regional Population of Wetlands North of Tampa Bay, Florida, from 1990 to 2015
Authors: Fouad Geoffrey , Lee Terrie M. 
Published: May 2021

Abstract
A groundwater condition metric is presented and used to evaluate hydrologic changes in a regional population of wetlands in and around municipal well fields with large groundwater withdrawals. The approach compares a 26-year, monthly time series of groundwater potentiometric surfaces to light detection and ranging (LiDAR) land-surface elevations at 10,516 wetlands in a 1505-square-kilometer area. Elevation differences between the potentiometric surface and wetland land surface provide a flow direction (upward or downward) and a proxy for vertical hydraulic head difference in Darcy’s groundwater flow equation. The resulting metric quantifies the groundwater condition at a wetland through time as the potential for groundwater to discharge upward into a wetland or for water in a wetland to leak downward to recharge the underlying aquifer. The potential for wetland leakage across the regional wetland population decreased by 33% in the 13 years after cutbacks in groundwater withdrawals (2003-2015) compared to years before cutbacks (1990-2002). Inside well field properties, wetland leakage potential decreased by 24%. In the wet season month of September, wetlands with the potential to receive groundwater discharge increased to 21.6% of the regional population after cutbacks compared to 13.3% before cutbacks. When mapped across regional drainage basins, discharging wetlands formed spatial connections suggesting they play a critical role in generating streamflow.
Deformations on a Talings Dam Embankment Due to Its Heightening and Reservoir Filling
Authors: Teixeira Sidnei Helder Cardoso , de Paiva Paulo Roberto , Junior Tennison Freire de Souza , Conte Eduardo , Silva Cezar 
Published: May 2021

Abstract
The purpose of this article is to evaluate the deformations of a compacted embankment dam, partially supported on tailings, through the use of two-dimensional and three-dimensional finite element models using PLAXIS® and TOCHNOG® software, respectively. The modeling was developed to simulate the construction of a complete dam stage, with a compacted embankment, a launched embankment platform, and the filling of the dam reservoir with the tailings. The material deformation parameters were calibrated so that the numerical modeling results are consistent with the data obtained from the instrumentation installed on the dam. The results made it possible to represent and understand the deformation mechanisms that occur during the construction of a raised stage and the filling of the reservoir.
Critical Metadata Analysis and Data Visualization of United States, United Kingdom, and Ireland World Leaders Twitter Responses to COVID-19
Authors: Kentish Esther Ruth 
Published: May 2021

Abstract
Governments use their personal social media platforms, specifically Twitter, to promote their messaging and the perception of the COVID-19 pandemic and highlight key strategies and policy priorities. Data presented on social media outlets differ from the data presented by the WHO and the CDC. This critical metadata analysis uses visual rhetoric because “rhetoric has come to be used not just as means of producing effective communications, but also as a way of understanding communication” (Selzer, p. 280). Further, the argument has been made that the governmental systems and leaders utilized Twitter to promote their personal views on and experiences with COVID-19, in addition to implementation strategies on how to deal with the pandemic, how to safely engage with others, and the rules for future public engagement.
Evolution of species complementarity in response to drought in a grassland biodiversity experiment
Authors: Chen Yuxin , Vogel Anja , Wagg Cameron , Xu Tianyang , Iturrate-Garcia Maitane , Scherer-Lorenzen Michael , Weigelt Alexandra , Eisenhauer Nico , Schmid Bernhard 
Published: May 2021

Abstract
Growing threats from extreme climatic events and biodiversity loss have raised concerns about their interactive consequences for ecosystem functioning. Evidence suggests that biodiversity is crucial to buffer ecosystem functioning facing climatic extremes. However, whether evolutionary processes in species mixtures underpin such biodiversity-dependent stabilizing effects remains elusive. We tested this hypothesis by exposing experimental mixtures of grassland species to eight recurrent summer droughts vs. control in the field. Seed offspring of 12 species were subsequently grown individually, in monocultures or in 2-species mixtures and subjected to a novel drought event in the glasshouse. Comparing mixtures with monocultures, drought-selected plants showed greater between-species complementarity than ambient-selected plants when recovering from the drought event, which led to greater biodiversity effects on community productivity and better recovery of drought-selected mixtures after the drought. These findings suggest biodiversity can buffer the impacts of extreme climatic events through evolution of species complementarity.
Etiological associations of Cerebral Venous Sinus Thrombosis (CVT) among Sudanese patients in Khartoum state Neurological Centers, Sudan, 2020
Authors: Malekaldar Mohamed , Hussien Abbasher , Ahmed Khabab Abbasher Hussien Mohamed , Abdalla Yassin 
Published: May 2021

Abstract
Background

As cerebral venous sinus thrombosis is common in our country and it carries a high risk of morbidity and mortality if it is not detected and treated early. The common aetiological associations of CVST are post-partum, pregnancy and oral contraceptive pills.
Objectives

To study the etiological association of CVST among Sudanese patients in Khartoum state in neurological centers.
Methodology

This is a descriptive prospective hospital based study was conducted on CVST patients in four neurological centers in Khartoum state in the period from March to October 2020.
Results

Sixty patients were studied for etiological association of CVST using standardized questionnaire including medical history, clinical examination, investigation and treatment. The most common etiological association were pregnancy in 15(25%) OCP in 11(18.3) and being in the post-partum period in 23(38.3%).
Recommendation

Cerebral venous sinus thrombosis is a treatable condition and has good outcome. Early detection of patients and performing suitable work up including thrombophilia and connective tissue disease screening is essential.
Conclusion

Post-partum, pregnancy and oral contraceptive pills were the most common etiological associations of cerebral venous sinus thrombosis compared with other populations.