bluuebunny/crossref_metadata_2025_split huggingface dataset:
Galectin-12 modulates sebocyte proliferation and cell cycle progression by regulating cyclin A1 and CDK2
Authors: Tsao Ching-Han , Hsieh Wei-Chen , Yang Ri-Yao , Lo Yuan-Hsin , Tu Ting-Jui , Ke Liang-Yin , Zouboulis Christos C , Liu Fu-Tong 
Published: September 2021

Abstract
Enhanced sebocyte proliferation is associated with the pathogenesis of human skin diseases related to sebaceous gland hyperfunction and androgens, which are known to induce sebocyte proliferation, are key mediators of this process. Galectin-12, a member of the β-galactoside-binding lectin family that is preferentially expressed by adipocytes and functions as an intrinsic negative regulator of lipolysis, has been shown to be expressed by human sebocytes. In this study, we identified galectin-12 as an important intracellular regulator of sebocyte proliferation. Galectin-12 knockdown in the human SZ95 sebocyte line suppressed cell proliferation, and its overexpression promoted cell cycle progression. Inhibition of galectin-12 expression reduced the androgen-induced SZ95 sebocyte proliferation and growth of sebaceous glands in mice, respectively. The mRNA expression of the key cell cycle regulators cyclin A1 (CCNA1) and cyclin-dependent kinase 2CDK2 was reduced in galectin-12 knockdown SZ95 sebocytes, suggesting a pathway of galectin-12 regulation of sebocyte proliferation. Further, galectin-12 enhanced peroxisome proliferator-activated receptor gamma (PPARγ) expression and transcriptional activity in SZ95 sebocytes, consistent with our previous studies in adipocytes. Rosiglitazone, a PPARγ ligand, induced CCNA1 levels, suggesting that galectin-12 may upregulate CCNA1 expression via PPARγ. Our findings suggest the possibility of targeting galectin-12 to treat human sebaceous gland hyperfunction and androgen-associated skin diseases.
Health Care Costs and Resource Utilization Among Patients With Crohn’s Disease With and Without Perianal Fistula
Authors: Chen Grace , Pedarla Vasantha , Null Kyle D , Cazzetta Susan E , Khan Qasim Rana , Schwartz David A 
Published: September 2021

Abstract

Background
Perianal fistula (PAF), a complication of Crohn’s disease (CD), is associated with substantial economic costs and poor prognosis. We determined prevalence of PAF CD in the United States and compared costs and health care resource utilization (HRU) of PAF CD patients with matched non-PAF CD patients.

Methods
This was a retrospective cohort study of claims data from the IBM MarketScan Commercial Database from October 1, 2015, to September 30, 2018. Eligible patients were aged 18 to 89 years with ≥2 CD diagnoses. Patients with PAF CD had ≥1 PAF diagnosis or procedure code and were matched with non-PAF CD patients. Cumulative prevalence of PAF CD in the US population was calculated across total patients in MarketScan. All-cause and gastrointestinal (GI)-related costs and HRU were compared between groups using a generalized linear model (GLM).

Results
Cumulative 3-year prevalence of PAF was 7.70% of patients with CD (N = 81,862) and 0.01% of the US population. Among PAF CD (n = 1218) and matched non-PAF CD (n = 4095) patients, most all-cause costs and HRU were GI-related. Mean total all-cause and GI-related health care costs per patient and per year for PAF CD were $85,233 and $71,612, respectively, vs $40,526 and $29,458 for non-PAF CD (P &lt; .0001). Among PAF CD vs non-PAF CD patients, GLM-adjusted proportions of patients with GI-related inpatient, outpatient, or pharmacy visits, mean GI-related inpatient length of stay, and mean GI-related surgeries were higher (P &lt; .0001 for all comparisons).

Conclusions
Costs and HRU are significantly higher for patients with PAF CD vs non-PAF CD patients, highlighting the economic burden of the disease.
Łojasiewicz Inequalities for Mean Convex Self-Shrinkers
Authors: Zhu Jonathan J 
Published: September 2021

AbstractWe prove Łojasiewicz inequalities for round cylinders and cylinders over Abresch–Langer curves, using perturbative analysis of a quantity introduced by Colding–Minicozzi. A feature is that this auxiliary quantity allows us to work essentially at 1st order. This new method interpolates between the higher-order perturbative analysis used by the author for certain shrinking cylinders and the differential geometric method used by Colding–Minicozzi for the round case.
Mucosal Immune Responses Against an Oral Enterotoxigenic Escherichia coli Vaccine Evaluated in Clinical Trials
Authors: Svennerholm Ann-Mari , Lundgren Anna , Leach Susannah , Akhtar Marjahan , Qadri Firdausi 
Published: September 2021

Abstract
Enterotoxigenic Escherichia coli (ETEC) is a leading cause of mortality and morbidity in children in low-income countries. We have tested an oral ETEC vaccine, ETVAX, consisting of inactivated E coli overexpressing the most prevalent colonization factors and a toxoid, LCTBA, administered together with a mucosal adjuvant, double-mutant heat-labile toxin (dmLT), for capacity to induce mucosal immune responses and immunological memory against the primary vaccine antigens, ie, colonization factors, heat-labile toxin B-subunit and O antigen. The studies show that ETVAX could induce strong intestine-derived and/or fecal immune responses in a majority of vaccinated Swedish adults and in different age groups, including infants, in Bangladesh.
Environmental Public Interest Litigation in China: Findings from 570 Court Cases Brought by NGOs, Public Prosecutors and Local Government
Authors: Xie Lei , Xu Lu 
Published: September 2021

Abstract
Environmental public interest litigation (EPIL) is an important development in the evolving framework of environmental governance in China. Through quantitative and qualitative analyses of decided cases brought by local government, public prosecutors and environmental non-governmental organisations (NGOs), this study critically examines the features, strengths, difficulties and obstacles in the EPIL practice of China. While there is remarkable success overall for all three groups in terms of outcome, they each display different approaches and focuses. The prosecutors have established themselves as the cornerstone of the system by being the most efficient in winning the greatest number of cases. NGOs moved away from collaboration with the prosecutors in low-value cases, effectively into a competition with the government in a smaller number of high-value cases, though they are willing to venture into areas where others hesitate over. The findings offer valuable insights into current EPIL practice and inform future policy adjustment and legislation.
Treatment of device thrombus in the HeartWare HVAD: surgical exchange through thoracotomy
Authors: Ghandour Amale , Cecere Renzo 
Published: September 2021

Abstract
Pump thrombosis can occur in patients with a left ventricular assist device (LVAD). It can be treated medically with thrombolytic agents or surgically. We present a case of a man who successfully underwent an LVAD swap via left anterior thoracotomy due to recurrent thromboses in the inflow cannula.
Investigation of the properties of four rotating radio transients at 111 MHz
Authors: Tyul’bashev S A , Smirnova T V , Brylyakova E A , Kitaeva M A 
Published: September 2021

ABSTRACT
We present an analysis of the individual pulses of four rotating radio transients (RRATs), previously discovered in a monitoring survey running for 5.5 yr at the frequency of 111 MHz. At a time interval equivalent to 5 d of continuous observations for each RRAT, 90, 389, 206 and 157 pulses were detected in J0640+07, J1005+30, J1132+25 and J1336+33, respectively. The investigated RRATs have different distributions of their pulse amplitudes. For J0640+07 and J1132+25, the distribution is described by a single exponent over the entire range of flux densities. For J1005+30 and J1336+33, it is a lognormal function with a power-law tail. For J0640+07 and J1005+30, we have detected pulses with a signal-to-noise ratio (S/N) of a few hundred. For J1132+25 and J1336+33, the S/N of the strongest pulses reaches several tens. These RRATs show a strong change in their emission. When the strengths of their pulse amplitudes are significantly changed, we see long intervals of absence of emission or its strong attenuation. The analysis carried out in this work shows that it is possible that all the studied RRATs are, apparently, pulsars with giant pulses.
The Pristine survey XIII: uncovering the very metal-poor tail of the thin disc
Authors: Fernández-Alvar Emma , Kordopatis Georges , Hill Vanessa , Starkenburg Else , Viswanathan Akshara , Martin Nicolas F , Thomas Guillaume F , Navarro Julio F , Malhan Khyati , Sestito Federico , González Hernández Jonay I , Carlberg Raymond G 
Published: September 2021

ABSTRACT
We evaluate the rotational velocity of stars observed by the Pristine survey towards the Galactic anticentre spanning a wide range of metallicities from the extremely metal-poor regime ([Fe/H] &lt; −3) to nearly solar metallicity. In the Galactic anticentre direction, the rotational velocity (Vϕ) is similar to the tangential velocity in the galactic longitude direction (Vℓ). This allows us to estimate Vϕ from Gaia early data release 3 (Gaia EDR3) proper motions for stars without radial velocity measurements. This substantially increases the sample of stars in the outer disc with estimated rotational velocities. Our stellar sample towards the anticentre is dominated by a kinematical thin disc with a mean rotation of ∼−220  km s−1. However, our analysis reveals the presence of more stellar substructures. The most intriguing is a well-populated extension of the kinematical thin disc down to [Fe/H] ∼ −2 . A scarcer fast-rotating population reaching the extremely metal-poor regime down to [Fe/H] ∼ −3.5 is also detected but without statistical significance to unambiguously state whether this is the extremely metal-poor extension of the thin disc or the high-rotating tail of hotter structures (like the thick disc or the halo). In addition, a more slowly rotating kinematical thick disc component is also required to explain the observed Vℓ distribution at [Fe/H] &gt; −1.5 . Furthermore, we detect signatures of a ‘heated disc’, the so-called Splash, at metallicities higher than ∼−1.5. Finally, at [Fe/H] &lt; −1.5 our anticentre sample is dominated by a kinematical halo with a net prograde motion.
The search for failed supernovae with the Large Binocular Telescope: N6946-BH1, still no star
Authors: Basinger C M , Kochanek C S , Adams S M , Dai X , Stanek K Z 
Published: September 2021

ABSTRACT
We present new Large Binocular Telescope, Hubble Space Telescope, and Spitzer Space Telescope data for the failed supernova candidate N6946-BH1. We also report an unsuccessful attempt to detect the candidate with Chandra. The ∼300 000 $\, \mathrm{L}_\odot$ red supergiant progenitor underwent an outburst in 2009 and has since disappeared in the optical. In the LBT data from 2008 May through 2019 October, the upper limit on any increase in the R-band luminosity of the source is $2000 \, \mathrm{L}_\odot$. HST and Spitzer observations show that the source continued to fade in the near-IR and mid-IR, fading by approximately a factor of 2 between 2015 October and 2017 September to 2900 $\, \mathrm{L}_\odot$ at Hband (F160W). Models of the spectral energy distribution are inconsistent with a surviving star obscured either by an ongoing wind or dust formed in the transient. The disappearance of N6946-BH1 remains consistent with a failed supernova, but the post-failure phenomenology requires further theoretical study.
GW Ori: circumtriple rings and planets
Authors: Smallwood Jeremy L , Nealon Rebecca , Chen Cheng , Martin Rebecca G , Bi Jiaqing , Dong Ruobing , Pinte Christophe 
Published: September 2021

ABSTRACT
GW Ori is a hierarchical triple star system with a misaligned circumtriple protoplanetary disc. Recent Atacama Large Millimeter/submillimeter Array observations have identified three dust rings with a prominent gap at $100\, \rm au$ and misalignments between each of the rings. A break in the gas disc may be driven by the torque from either the triple star system or a planet that is massive enough to carve a gap in the disc. Once the disc is broken, the rings nodally precess on different time-scales and become misaligned. We investigate the origins of the dust rings by means of N-body integrations and 3D hydrodynamic simulations. We find that for observationally motivated parameters of protoplanetary discs, the disc does not break due to the torque from the star system. We suggest that the presence of a massive planet (or planets) in the disc separates the inner and outer discs. We conclude that the disc breaking in GW Ori is likely caused by undetected planets – the first planet(s) in a circumtriple orbit.
A deep search for faint Chandra X-ray sources, radio sources, and optical counterparts in NGC 6752
Authors: Cohn Haldan N , Lugger Phyllis M , Zhao Yue , Tudor Vlad , Heinke Craig O , Cool Adrienne M , Anderson Jay , Strader Jay , Miller-Jones James C A 
Published: September 2021

ABSTRACT
We report the results of a deep search for faint Chandra X-ray sources, radio sources, and optical counterparts in the nearby, core-collapsed globular cluster, NGC 6752. We combined new and archival Chandra imaging to detect 51 X-ray sources (12 of which are new) within the 1.9 arcmin half-light radius. Three radio sources in deep ATCA 5 and 9 GHz radio images match with Chandra sources. We have searched for optical identifications for the expanded Chandra source list using deep Hubble Space Telescope photometry in B435, R625, H α, UV275, and U336. Among the entire sample of 51 Chandra sources, we identify 18 cataclysmic variables (CVs), 9 chromospherically active binaries (ABs), 3 red giants (RGs), 3 galaxies (GLXs), and 6 active galactic nuclei (AGNs). Three of the sources are associated with millisecond pulsars (MSPs). As in our previous study of NGC 6752, we find that the brightest CVs appear to be more centrally concentrated than the faintest CVs, although the effect is no longer statistically significant as a consequence of the inclusion in the faint group of two intermediate brightness CVs. This possible difference in the radial distributions of the bright and faint CV groups appears to indicate that mass segregation has separated them. We note that photometric incompleteness in the crowded central region of the cluster may also play a role. Both groups of CVs have an inferred mass above that of the main-sequence turnoff stars. We discuss the implications for the masses of the CV components.
Blast from the past: constraining progenitor models of SN 1972E
Authors: Do Aaron , Shappee Benjamin J , De Cuyper Jean-Pierre , Tonry John L , Hunt Cynthia , Schweizer François , Phillips Mark M , Burns Christopher R , Beaton Rachael , Hainaut Olivier 
Published: September 2021

ABSTRACT
We present a novel technique to study Type Ia supernovae (SNe Ia) by constraining surviving companions of historical extragalactic SN by combining archival photographic plates and Hubble Space Telescope(HST) imaging. We demonstrate this technique for Supernova 1972E, the nearest known SN Ia in 125 yr. Some models of SNe Ia describe a white dwarf with a non-degenerate companion that donates enough mass to trigger thermonuclear detonation. Hydrodynamic simulations and stellar evolution models show that these donor stars will survive the explosion, and show increased luminosity for at least a 1000 yr. Thus, late-time observations of the exact location of a supernova can constrain the presence of a surviving donor star and progenitor models. We find the explosion site of SN 1972E by analysing 17 digitized photographic plates taken with the European Southern Observatory 1-m Schmidt and 1 plate taken with the Cerro Tololo Inter-American Observatory 1.5-m telescope. Using the Gaia eDR3 catalogue to determine Supernova 1972E’s location yields: α = 13h39m52${_{.}^{\rm s}}$708 ± 0${_{.}^{\rm s}}$004 and δ = −31°40’9${_{.}^{\prime\prime}}$00 ± 0${_{.}^{\prime\prime}}$04 (ICRS). In 2005, HST/ACS imaged the host galaxy of SN 1972E with the F435W, F555W, and F814W filters covering the explosion site. The nearest detected source is offset by 3.0 times our positional precision, and is inconsistent with the colours expected of a surviving donor star. Thus, the limiting magnitude of the HST observation (F555W &gt; 28 mag) rules out all He star companion models and the most luminous main-sequence companion model currently in the literature. The remaining main-sequence companion models could be tested with a 10 orbit HST exposure in the F606W filter.
The K2-OjOS Project: New and revisited planets and candidates in K2 campaigns 5, 16, & 18
Authors: Castro-González A , Díez Alonso E , Menéndez Blanco J , Livingston J , de Leon J P , Lillo-Box J , Korth J , Fernández Menéndez S , Recio J M , Izquierdo-Ruiz F , Coya Lozano A , García de la Cuesta F , Gómez Hernández N , Vidal Blanco J R , Hevia Díaz R , Pardo Silva R , Pérez Acevedo S , Polancos Ruiz J , Padilla Tijerín P , Vázquez García D , Suárez Gómez S L , García Riesgo F , González Gutiérrez C , Bonavera L , González-Nuevo J , Rodríguez Pereira C , Sánchez Lasheras F , Sánchez Rodríguez M L , Muñiz R , Santos Rodríguez J D , de Cos Juez F J 
Published: September 2021

ABSTRACT
We present the first results of K2-OjOS, a collaborative project between professional and amateur astronomers primarily aimed to detect, characterize, and validate new extrasolar planets. For this work, 10 amateur astronomers looked for planetary signals by visually inspecting the 20 427 light curves of K2 campaign 18 (C18). They found 42 planet candidates, of which 18 are new detections and 24 had been detected in the overlapping C5 by previous works. We used archival photometric and spectroscopic observations, as well as new high-spatial resolution images in order to carry out a complete analysis of the candidates found, including a homogeneous characterization of the host stars, transit modelling, search for transit timing variations and statistical validation. As a result, we report four new planets (K2-355 b, K2-356 b, K2-357 b, and K2-358 b) and 14 planet candidates. Besides, we refine the transit ephemeris of the previously published planets and candidates by modelling C5, C16 (when available) and C18 photometric data jointly, largely improving the period and mid-transit time precision. Regarding individual systems, we highlight the new planet K2-356 b and candidate EPIC 211537087.02 being near a 2:1 period commensurability, the detection of significant TTVs in the bright star K2-184 (V = 10.35), the location of K2-103 b inside the habitable zone according to optimistic models, the detection of a new single transit in the known system K2-274, and the disposition reassignment of K2-120 b, which we consider as a planet candidate as the origin of the signal cannot be ascertained.
A pathogen-specific sRNA influences enterohemorrhagic Escherichia coli fitness and virulence in part by direct interaction with the transcript encoding the ethanolamine utilization regulatory factor EutR
Authors: Sauder Amber B , Kendall Melissa M 
Published: September 2021

Abstract
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 relies on sRNAs to coordinate expression of metabolic and virulence factors to colonize the host. Here, we focus on the sRNA, named MavR (metabolism and virulence regulator), that is conserved among pathogenic Enterobacteriaceae. MavR is constitutively expressed under in vitro conditions that promote EHEC virulence gene expression. Using MS2-affinity purification coupled with RNA sequencing, the eutR transcript was identified as a putative target of MavR. EutR is a transcription factor that promotes expression of genes required for ethanolamine metabolism as well as virulence factors important for host colonization. MavR binds to the eutR coding sequence to protect the eutR transcript from RNase E-mediated degradation. Ultimately, MavR promotes EutR expression and in turn ethanolamine utilization and ethanolamine-dependent growth. RNAseq analyses revealed that MavR also affected expression of genes important for other metabolic pathways, motility, oxidative stress and attaching and effacing lesion formation, which contribute to EHEC colonization of the gastrointestinal tract. In support of the idea that MavR-dependent gene expression affects fitness during infection, deletion of mavR resulted in significant (∼10- to 100-fold) attenuation in colonization of the mammalian intestine. Altogether, these studies reveal an important, extensive, and robust phenotype for a bacterial sRNA in host-pathogen interactions.
Ethylenediamine derivatives efficiently react with oxidized RNA 3′ ends providing access to mono and dually labelled RNA probes for enzymatic assays andin vivotranslation
Authors: Mamot Adam , Sikorski Pawel J , Siekierska Aleksandra , de Witte Peter , Kowalska Joanna , Jemielity Jacek 
Published: September 2021

AbstractDevelopment of RNA-based technologies relies on the ability to detect, manipulate, and modify RNA. Efficient, selective and scalable covalent modification of long RNA molecules remains a challenge. We report a chemical method for modification of RNA 3′-end based on previously unrecognized superior reactivity of N-substituted ethylenediamines in reductive amination of periodate-oxidized RNA. Using this method, we obtained fluorescently labelled or biotinylated RNAs varying in length (from 3 to 2000 nt) and carrying different 5′ ends (including m7G cap) in high yields (70–100% by HPLC). The method is scalable (up to sub-milligrams of mRNA) and combined with label-facilitated HPLC purification yields highly homogeneous products. The combination of 3′-end labelling with 5′-end labelling by strain-promoted azide-alkyne cycloaddition (SPAAC) afforded a one-pot protocol for site-specific RNA bifunctionalization, providing access to two-colour fluorescent RNA probes. These probes exhibited fluorescence resonance energy transfer (FRET), which enabled real-time monitoring of several RNA hydrolase activities (RNase A, RNase T1, RNase R, Dcp1/2, and RNase H). Dually labelled mRNAs were efficiently translated in cultured cells and in zebrafish embryos, which combined with their detectability by fluorescent methods and scalability of the synthesis, opens new avenues for the investigation of mRNA metabolism and the fate of mRNA-based therapeutics.