bluuebunny/crossref_metadata_2025_split huggingface dataset:
Symmetrical drug‐related intertriginous and flexural exanthema/baboon syndrome induced by traditional Chinese medicine
Authors: Liu Jing , Li Lin‐feng 
Published: August 2021

AbstractBackgroundSymmetrical drug‐related intertriginous and flexural exanthema (SDRIFE) refers to an uncommon cutaneous adverse reaction that symmetrically involves the buttock and intertriginous areas after systemic exposure to the offending drug and is previously known as baboon syndrome. SDRIFE related with traditional Chinese medicine (TCM) has not been reported.ObjectiveWe presented a case of SDRIFE /baboon syndrome induced by TCM, Xi‐Huang capsule.MethodsA 57‐years‐old man presented with macular erythematous rash mainly on his intergluteal, inguinal, axillary, popliteal regions for a duration of 5 days. The lesions appeared a day after an oral Chinese patent medicine Xi‐Huang capsule for arthralgia. Drug eruption was diagnosed. The rash disappeared completely within a week with immediate discontinuation of Xi‐Huang capsule and a short term of systemic therapy with glucocorticosteroids. Patch testing was performed on the patient 1 month after complete resolution. He was patch tested with Xi‐Huang capsule (5% and 10% in petroleum) using Finn Chambers on Scanpor tape and T.R.U.E. test system. Five heathy volunteers were also patch tested with the same Xi‐Huang capsule.ResultsPatch testing to 20 common contact allergens including nickel and fragrance were negative. TCM patch test was positive. No positive results were found in five volunteers. Months later, the patient relapsed after an oral herbal Chinese medicine challenge for arthralgia. To avoid the rash recurrence, he stopped taking any Chinese herbal medicine and had complete resolution of disease.ConclusionThe Chinese patent drugs for external and oral have unique advantages and have been widely used in many diseases. It is important that dermatologists monitor for clinically significant manifestations of TCM, such as baboon syndrome. Patch testing could help make a definitive diagnosis.
A randomized, controlled, split‐face study of topical timolol maleate 0.5% eye drops for the treatment of erythematotelangiectatic rosacea
Authors: Wei Danfeng , Hamblin Michael R. , Wen Xiang 
Published: August 2021

AbstractBackgroundCentrofacial erythema associated with telangiectasis is the most common presentation of rosacea, known as erythematotelangiectatic rosacea (ETR). However, successful management of these symptoms remains challenging.AimThe purpose of this study was to evaluate the efficacy and safety of topical timolol maleate eye drops 0.5% for ETR.MethodsIn this randomized, single‐center, single‐blind, placebo‐controlled split‐face study, 16 patients with mild‐to‐moderate ETR who presented at West China Hospital between January 2019 to September 2020 were randomized to receive either topical timolol maleate eye drops 0.5% to one side of their face daily for 28 days and normal saline to the other side of the face. Patients were assessed with both the Clinician Erythema Assessment (CEA) and Patient Self‐Assessment (PSA) at the 28‐day follow‐up appointment. Subjective assessment was performed by asking participants to grade their sensation of warmth and burning.ResultsThe sides treated with timolol demonstrated a significant improvement in both the CEA and PSA at the 28‐day assessment. Patients reported a significant difference in warmth and burning sensations. The only adverse reaction was worsened redness on both sides of the face at Day 1 in one patient.ConclusionsIn this small study, the application of topical timolol maleate was safe and effective for the treatment of ETR.
Evaluation of the evidence level for the use of radiofrequency in aesthetic treatments: A systematic review and meta‐analysis
Authors: Oliveira Paggiaro André , Pinheiro Rafael , Soares Kaolanna , Fernandes Carvalho Viviane , Gemperli Rolf 
Published: August 2021

AbstractBackgroundRadiofrequency (RF) is a non‐invasive or minimally invasive procedure with a low risk of complications. It has been employed for several aesthetic purposes.AimThis study aimed to conduct a systematic literature review on the use of RF for aesthetic applications and assess the level of accumulated evidence for each condition.MethodsUsing the MEDLINE/PubMed and EMBASE databases, we searched for articles published from 2009 to 2019 describing the use of RF treatment for aesthetic purposes.ResultsOur search approach identified 25 randomized clinical trials investigating the efficacy of RF in the following clinical situations: body contour improvement, facial rejuvenation, acne scar treatment, alopecia, and rosacea. There were problems with the quality of the studies, especially regarding selection, performance, and detection bias.ConclusionOur study revealed that RF treatment is potentially promising in all of the evaluated clinical situations; however, we were not able to identify a level of evidence that justifies its use over other therapeutic options currently available on the market.
The combined effect of CO2 laser, topical diclofenac 3%, and imiquimod 5% in treating high‐risk basal cell carcinoma
Authors: El‐Khalawany Mohamed , Saudi Wael M. , Ahmed Eman , Mosbeh Alsadat , Sameh Ahmed , Rageh Mahmoud A. 
Published: August 2021

AbstractBackgroundSome basal cell carcinoma (BCC) patients are considered as a high risk regarding the site, size, histopathological variant, or recurrence. High‐risk BCC is a challenging therapeutic problem due to the trial to balance between complete surgical excision from one side and tissue preservation from the other side.AimTo evaluate the efficacy of combining ablative CO2 laser, imiquimod 5%, and diclofenac 3% as a therapeutic regimen in high‐risk and inoperable BCC.Patients/MethodsThe study was conducted on 14 patients that were assessed clinically and pathologically then categorized regarding the site, size, histopathology, and fitness for surgery as high‐risk inoperable BCC. They received an ablative session of CO2 laser, followed by application of diclofenac sodium 3% gel once daily for 5 days and imiquimod 5% cream for another 2 days.ResultsThe study included 11 males and 3 females. Nine lesions were located on the scalp, 4 on the face, and one lesion on the trunk. All lesions were of large size >5 cm in diameter. Histopathology showed 4 patterns: nodular type in 8 patients, infiltrating type in 3 patients, metatypical type in 2 patients, and micronodular type in one patient. At the end of the treatment period, 9 patients showed significant (moderate to marked) improvement while 5 patients showed weak (poor to mild) response. Significant improvement was more observed in nodular type. Relapse was more observed during the 5th to 6th months with 2 patients showed no relapse.ConclusionThis combined regimen is a good alternative therapeutic modality in high‐risk inoperable BCC especially the nodular pathologic pattern.
A split‐face clinical trial of conventional red‐light photodynamic therapy versus daylight photodynamic therapy for acne vulgaris
Authors: Slutsky‐Bank Evgenia , Artzi Ofir , Sprecher Eli , Koren Amir 
Published: August 2021

AbstractBackgroundPhotodynamic therapy (PDT) is considered an effective treatment for acne vulgaris. A significant drawback is pain during illumination. Daylight PDT (DL‐PDT) is more tolerable.ObjectiveTo assess and compare the efficacy and tolerability of DL‐PDT and C‐PDT for acne vulgaris through a prospective split‐face trial.Methods and MaterialsFifteen patients underwent 4 treatment sessions at 3‐week intervals. First, 5‐aminolevulinic acid (ALA) was applied to the entire face, after which the face was divided into 2 symmetrical areas: The right side was exposed to sunlight, and the left half was illuminated with red light. Photographs were obtained and evaluated by two dermatologists blinded to the study protocol. The patients reported side effects and downtime.ResultsThere was a statistically significant decrease in the number and percent change of inflammatory and non‐inflammatory lesions on both sides. Adverse effects were markedly decreased on the DL‐PDT side compared to the C‐PDT side (p < .01). The average downtime duration was longer for the C‐PDT side (p < .001).ConclusionDL‐PDT was at least as effective as C‐PDT with fewer adverse effects and a shorter downtime duration.
What is the impact of corpus uterine invasion on oncologic outcomes in surgically treated cervical cancer?
Authors: Turan Taner , Kimyon Comert Gunsu , Boyraz Gokhan , Kilic Fatih , Cakir Caner , Kilic Cigdem , Yuksel Dilek , Unsal Mehmet , Karalok Alper , Turkmen Osman 
Published: August 2021

AbstractAimTo investigate the clinical significance of uterine corpus involvement in patients with surgically treated cervical cancer.MethodsPatients (n = 354) with clinical early‐stage (stage IB1‐IIA2) cervical cancer who underwent radical hysterectomy and pelvic ± paraaortic lymphadenectomy were evaluated.ResultsUterine invasion was detected in 60 (16.9%) patients. Patients with uterine invasion had a higher rate of pelvic lymph node metastasis than those without uterine invasion (35% vs 22.8%, p = 0.046). In multivariate analysis, no statistically significant difference was identified between patients with and without uterine invasion for pelvic lymph node metastasis (p = 0.953). Uterine invasion was identified as an independent risk factor for paraaortic lymph node metastasis in multivariate analysis (p = 0.012). The presence of pelvic lymph node metastasis was found to be another significant predictor of paraaortic lymph node involvement (p = 0.022). In addition, uterine invasion and lymph node metastasis were identified as an independent risk factors regarding poor prognosis in cancer‐specific survival (hazard ratio [HR]: 4.537; 95% confidence interval [CI], 1.304–15.782; p = 0.017 and HR: 5.598; 95% CI, 1.581–19.823; p = 0.008, respectively).ConclusionsUterine invasion is an independent predictor of decreased survival and the presence of paraaortic lymph node metastasis in cervical cancer. The presence of the uterine invasion in cervical cancer should be considered as a poor prognostic factor in the decision of treatment.
Occlusal disharmony and chronic oro‐facial pain: from clinical observation to animal study
Authors: Cao Ye 
Published: August 2021

AbstractBackgroundOcclusion can be viewed as the most sensitive susceptor of the central nervous system in the oro‐facial region. Its inalienable relationships to the temporomandibular joint, the muscles, the stomatognathic system and even the central nervous system are self‐evident. Almost all the dental treatments inevitably change the occlusion, potentially or actually, locally or extensively, and immediately or gradually.ObjectiveThe objective of this study was to present a narrative literature on occlusal disharmony and chronic oro‐facial pain.MethodsLiterature reviews focusing on clinical studies about the relationship between occlusal disharmony and myofascial oro‐facial pain, and related preclinical studies about the animal models of, as well as the peripheral and central mechanisms underlying this condition related to, occlusal disharmony were used as starting point and guidelines to describe the topics mentioned. A search of the PubMed database was performed mainly with the following search terms: “occlusion,” “occlusal interference,” “occlusal disharmony,” “occlusal change,” “oro‐facial pain” and “myofascial pain.”ResultsRelevant literature from the past 70 years until the present day was meticulously studied. The literature review together with three related characteristic clinical cases revealed an intimate association between occlusal disharmony and chronic oro‐facial pain, involving pathological changes, extending from the peripheral tissues to the central nervous system. The patients suffered from psychological distress, sleep disturbance and poor life quality.ConclusionOcclusal disharmony–related oro‐facial pain is a clinical problem that deserves attention, although there are no universally accepted clinical protocols. The existing literature provides some constructive suggestions, but further research is needed.
Occurrence and characterization of Bipolaris setariae associated with leaf blight of browntop millet (Brachiaria ramosa) in India
Authors: Ramesh Gutha Venkata , Palanna Kaki Boraiah , Vinaykumar Hargi Devappa , Arunkumar  , Koti Prasanna S. , Mahesha Hosapura Shekhararaju , Nagaraja Thathigowdara Enkeswarappa , Tonapi Vilas A. , Jeevan B. 
Published: August 2021

AbstractA new leaf blight disease of browntop millet (Brachiaria ramosa) was noticed during rainy season (Kharif) 2018 at small millet experimental field, University of Agricultural Sciences, Gandhi Krishi Vignana Kendra (GKVK), Bengaluru, India. To assess the disease severity, an intensive roving survey was conducted during the 2019 cropping season. Based on the morphological characterization, the causal agent of leaf blight disease was identified as Bipolaris spp. Further sequencing and combined gene analysis of ITS (internal transcribed spacer of rDNA), GAPDH (glyceraldehyde 3‐phosphate dehydrogenase) and LSU (large subunit) of all the nine isolates confirmed the pathogen as B. setariae. Pathogenicity study showed that all the isolates were pathogenic and caused leaf blight symptoms on browntop millet. The B. setariae isolates showed marked variability with respect to disease incidence on browntop millet (cv. Dundu korale) under artificial inoculation conditions. However, the host range was limited only to browntop millet and found non‐pathogenic to other six small millets examined. To our knowledge, this is the first completely described study on characterization of B. setariae causing leaf blight disease of browntop millet in India.
Psychological and work‐related factors associated with emotional exhaustion among healthcare professionals during the COVID‐19 outbreak in Italian hospitals
Authors: Fiabane Elena , Gabanelli Paola , La Rovere Maria Teresa , Tremoli Elena , Pistarini Caterina , Gorini Alessandra 
Published: August 2021

AbstractThe coronavirus disease 2019 (COVID‐19) pandemic has induced considerable psychological distress in healthcare workers, increasing the risk of burnout. This research aimed to investigate sociodemographic, work‐related, COVID‐19‐related, and psychological factors associated with emotional exhaustion (the core component of burnout) among healthcare professionals during the first wave of the COVID‐19 pandemic in Italy. A cross‐sectional study was conducted to assess risk (e.g. perceived risk and fear of contagion, stress) and protective factors (e.g. job satisfaction, resilience) for emotional exhaustion among 616 hospital staff. Women, nurses, shift workers, those with a permanent contract, and frontline workers reported significantly higher levels of emotional exhaustion compared to others. Significant risk factors predicting emotional exhaustion were prolonged use of personal protective equipment, increased work pressure, lack of support, and prolonged working hours; psychologically protective factors were resilience and job satisfaction, while perceived stress was found to be a significant psychological risk factor. Organizational interventions should focus on these factors to prevent the onset of burnout.
Oral mucosal lesions in pregnant women: A population‐based study
Authors: Duarte da Silva Karine , Vargas‐Ferreira Fabiana , Dâmaso Bertoldi Andréa , Celso Lopes Fernandes de Barros Fernando , Fernando Demarco Flávio , Britto Correa Marcos , Beatriz Chaves Tarquinio Sandra 
Published: August 2021

AbstractObjectiveTo evaluate the prevalence of oral mucosal lesions (OML) and oral self‐examination and their associated factors among pregnant women from the 2015 Pelotas Birth Cohort Study, Brazil.MethodsPregnant women who would deliver babies in 2015 were included in the antenatal study. Data related to demographic, socio‐economic and behavioural conditions were collected using questionnaires. Participants were also clinically assessed for oral health outcomes. The outcomes were the presence of OMLs and oral self‐examination. Size, location, time of onset and symptomatology of the lesions were collected. Descriptive and bivariate analysis, and Poisson regression were performed. p‐Value <0.05 was set to indicate statistical significance.ResultsData from 2481 pregnant women were analysed. Four hundred and nine (16.5%) had at least one OML. The most prevalent lesions were exostosis (80/16.6%), coated tongue (70/14.5%) and benign oral brownish pigmentation (68/14.1%). Non‐white skin colour was associated with a higher prevalence of OMLs (PR 1.3; 95% CI 1.1–1.6), while daily use of dental floss was positively associated with the prevalence of oral self‐examination (PR 1.4; 95% CI 1.2; 1.5).ConclusionsAlmost 20% of pregnant women presented OML, which were more prevalent in non‐white individuals. Women with better oral care were more likely to perform oral self‐examination.
Malignant peripheral nerve sheath tumour of the oral and maxillofacial region—A systematic review
Authors: Schuch Lauren Frenzel , Kirschnick Laura Borges , de Arruda José Alcides Almeida , Klein Isadora Peres , Silveira Felipe Martins , Vasconcelos Ana Carolina Uchoa , Santos‐Silva Alan Roger , Lopes Márcio Ajudarte , Carrard Vinicius Coelho , Vargas Pablo Agustin , Martins Marco Antonio Trevizani , Wagner Vivian Petersen , Martins Manoela Domingues 
Published: August 2021

AbstractTo integrate the available data published on malignant peripheral nerve sheath tumours (MPNST) of the oral and maxillofacial region. Searches in Embase, PubMed, Web of Science and Scopus were conducted for the identification of case reports/case series in English language. The risk of bias was assessed using the Joanna Briggs Institute tool. Outcomes were evaluated by Cox regression and Kaplan–Meier methods. A total of 306 articles were retrieved, 50 of which reporting 57 MPNST were included. The lesion showed a predilection for the mandible (n = 18/31.57%) of middle‐aged adults (~40.5 years) with a male/female ratio of 1.1:1. The individuals were mostly symptomatic with a mean evolution time of 9.6 months. Surgical removal plus adjuvant therapy (especially radiotherapy) was the main approach (51.86%). Recurrence was reported in 39.62% of cases. Nodal and distant metastases were identified in 28.26% and 26.66% of cases, respectively. The 2‐year cumulative survival rate was 55%. Independent predictors of poor survival were the presence of neurofibromatosis type 1 (p = 0.04) and distant metastases (p = 0.004). The diagnosis of MPNST is challenging due to the variety of its clinical and histopathological presentations. Local aggressiveness and the potential for metastases are common outcomes of this neoplasm.
Identification of competing endogenous RNA network in laryngeal squamous cell carcinoma
Authors: Cui Xiao‐Feng , Zhang Si‐Lin , Wang Wei‐Ping , Huang Xiao‐Wu , Chen Xiang‐Jun 
Published: August 2021

AbstractObjectiveThis study was conducted to investigate key long noncoding RNAs (lncRNAs) involved in competitive endogenous RNA (ceRNA) network associated with laryngeal squamous cell carcinoma (LSCC).Materials and MethodsThree mRNA datasets, two miRNA datasets, and one lncRNA dataset of LSCC were downloaded from GEO database. Following the identification of differentially expressed mRNAs (DEmRNAs), (microRNAs) miRNAs (DEmiRNAs), and lncRNAs (DElncRNAs) in LSCC compared with adjacent tissues, functional enrichment of DEmRNAs was performed. Then, construction of the ceRNA (DElncRNA‐DEmiRNA‐DEmRNA) regulatory network and functional analyses of all DEmRNAs in ceRNA regulatory network were conducted. Quantitative real‐time polymerase chain reactions (qRT‐PCR) were used to detect the expression levels of selected DEmRNAs, DEmiRNAs, and DElncRNAs.ResultsA total of 3449 DEmRNAs, 40 DEmiRNAs, and 100 DElncRNAs were identified in LSCC. The ceRNA networks, which contained 132 DElncRNA‐DEmiRNA pairs and 287 DEmiRNA‐DEmRNA pairs, involving 44 lncRNAs, 3 miRNAs, and 271 mRNAs, were obtained. DEmRNAs in ceRNA regulatory networks were significantly enriched in pathways in cancer, prostate cancer, and aldosterone‐regulated sodium reabsorption. Except for HCG22 and hsa‐miR‐1246, expressions of the others in the qRT‐PCR results played the same pattern with that in our integrated analysis, generally.ConclusionsWe concluded that HCG22/EGOT‐hsa‐miR‐1275‐FAM107A and HCG22/EGOT‐hsa‐miR‐1246‐Glycerol‐3‐phosphate dehydrogenase 1 like interaction pairs may play a central role in LSCC.
MiR‐144/451a cluster synergistically modulates growth and metastasis of Oral Carcinoma
Authors: Manasa Vidyadharan Geetha , Thomas Shaji , Kannan Sankarareddiar 
Published: August 2021

AbstractObjectivesMicroRNA (miRNA) clusters co‐transcribe and function in a coordinated fashion mediating synergistic or antagonistic regulatory effects. MiR‐144 and miR‐451a are deregulated in various cancers but the combined regulatory role of miR‐144/451a cluster in oral squamous cell carcinoma (OSCC) remains unexplored. In the present study, we studied the synergistic effect of miR‐144/451a cluster on oral cancer progression.Materials and methodsmiR‐144 and miR‐451a expression was explored in OSCC cell lines by quantitative real‐time PCR (qRT‐PCR). Proliferation, wound healing, migration and invasion, spheroid formation, and colony formation assays were performed after transfection with miR‐144‐3p, miR‐451a, miR‐144‐5p, and co‐expressed miR‐144/451a. Expression of putative target genes was analyzed using qRT‐PCR and Western blotting.ResultsmiR‐144 and miR‐451a were downregulated in all cell lines. The cell viability and stemness of cancer cell lines were unaltered when treated with miRNA mimics. However, co‐expressed miR‐144/451a significantly reduced the migratory, invasive, and clonogenic potential of cells than individual miRNAs.ConclusionmiR‐144/451a cluster functions as a tumor suppressor in OSCC by inhibiting cancer cell invasion, migration, and clonogenic potential.
The impaired unfolded protein‐premelanosome protein and transient receptor potential channels‐autophagy axes in apoptotic melanocytes in vitiligo
Authors: Xie Bo , Song Xiuzu 
Published: August 2021

AbstractVitiligo is an autoimmune skin disease, characterized by depigmentation and epidermal melanocytes loss. The specific mechanisms underlying vitiligo have not been fully understood. As a result, treating vitiligo is a dermatological challenge. Recently, much attention has been paid to the dysfunction and interaction of organelles under environmental stress. The impaired organelles could generate misfolded proteins, particularly accumulated toxic premelanosome protein (PMEL) amyloid oligomers, activating the autoimmune system and cause melanocyte damage. Unfolded protein response (UPR) dysfunction accelerates toxic PMEL accumulation. Herein, we presented a narrative review on UPR’s role in vitiligo, the misfolded PMEL‐induced attack of the autoimmune system under autophagy dysfunction caused by abnormal activation of transient receptor potential (TRP) channels and the background of UPR system defects in melanocytes. All of these mechanisms were integrated to form UPR/PMEL‐TRP channels/autophagy axis, providing a new understanding of vitiligo pathogenesis.