bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trypanosoma rangeli infection increases the exposure and predation endured by Rhodnius prolixus
Authors: Marliére Newmar Pinto , Lorenzo Marcelo Gustavo , Guarneri Alessandra Aparecida 
Published: September 2021

AbstractTrypanosoma rangeli is a protozoan that infects triatomines and mammals in Latin America, sharing hosts with Trypanosoma cruzi, the etiological agent of Chagas disease. Trypanosoma rangeli does not cause disease to humans but is strongly pathogenic to its invertebrate hosts, increasing mortality rates and affecting bug development and reproductive success. We have previously shown that this parasite is also capable of inducing a general increase in the locomotory activity of its vector Rhodnius prolixus in the absence of host cues. In this work, we have evaluated whether infection impacts the insect–vertebrate host interaction. For this, T. rangeli-infected and uninfected R. prolixus nymphs were released in glass arenas offering single shelters. After a 3-day acclimatization, a caged mouse was introduced in each arena and shelter use and predation rates were evaluated. Trypanosoma rangeli infection affected all parameters analysed. A larger number of infected bugs was found outside shelters, both in the absence and presence of a host. Infected bugs also endured greater predation rates, probably because of an increased number of individuals that attempted to feed. Interestingly, mice that predated on infected bugs did not develop T. rangeli infection, suggesting that the oral route is not effective for these parasites, at least in our system. Finally, a smaller number of infected bugs succeeded in feeding in this context. We suggest that, although T. rangeli is not transmitted orally, an increase in the proportion of foraging individuals would promote greater parasite transmission rates through an increased frequency of very effective infected-bug bites.
The conversions of ʿAbdallāh ibn Salām (d. 43/633): A legendary moment in the biography of Muḥammad's Jewish companion
Authors: Stafford Samuel A. 
Published: September 2021

AbstractThe Jewish scholar ʿAbdallāh b. Salām is a legendary figure from early Islam who is regarded in Islamic tradition as the archetypal Jewish convert to Islam during the Prophet's career, the pre-eminent authority on Jewish scriptures in seventh-century Arabia, and a renowned Companion. This study examines the traditions on Ibn Salām's conversion that were recorded in the biographical literature and Quranic commentaries of classical Islam and identifies the literary tropes from Muḥammad's biography featured in these traditions. Scrutiny of the evidence shows that the reports on the date and circumstances of Ibn Salām's conversion were shaped by a number of factors, including, the biases of his descendants, Quranic exegesis, and anti-Jewish polemics. Ibn Salām's legendary conversion served as a vehicle for diverse groups of Muslims to promote their doctrines and supply the Prophet with Biblical legitimacy.
Robust adaptive controller–observer scheme for robot manipulators: a Bernstein–Stancu approach
Authors: Izadbakhsh Alireza , Nikdel Nazila 
Published: September 2021

AbstractThis article introduces a robust adaptive controller–observer structure for robotic manipulators such that the need for joints speed measurement is removed. Besides, it is presumed that the system model has uncertainties and is subject to disturbances, and the proposed method must eliminate the impact of these factors on the system response. According to this, for the first time in the robotics field, a model-free scheme is developed based on the Bernstein–Stancu polynomial. The universal approximation property of the Bernstein–Stancu polynomial enables it to accurately estimate the lumped uncertainty, including unmodeled dynamics and disturbances. Moreover, to increase the efficiency of the controller–observer structure, adaptive rules have been proposed to update polynomial coefficients. The boundedness of all system errors is proven using the Lyapunov theorem. Finally, the proposed robust Adaptive controller–observer is applied on a planer robot, and the results are precisely analyzed. The results of the proposed approach are also compared with two state-of-art powerful approximation methods.
The first epidemiological and virological influenza surveillance in the Republic of Guinea revealed the predominance of influenza A/H3N2 and B Victoria viruses
Authors: Keita Mamadou Bhoye , Pierre Fenano , Ndjomou Jean , Traoré Bassala , Tohonamou Pepe , Soumaré Mafoudia , Mamadi Sidibé , Keita Moussa Aminata , Bile Célestin Ebi , Pallawo Raymond Bernard , Rajatonirina Soatiana Cathycia , Barry Ahmadou , Koivogui Lamine , Camara Robert , Touré Abdoulaye 
Published: September 2021

Abstract
Little is known about respiratory viruses infection in Guinea. Influenza surveillance has not been implemented in Guinea mainly because of the paucity of laboratory infrastructure and capacity. This paper presents the first influenza surveillance data in Guinea.
Swabs were obtained from August 2018 through December 2019 at influenza sentinel sites and transported to the Institut National de Santé Publique for testing. Ribonucleic acid was extracted and tested for the presence of influenza A and B by real-time reverse transcription-polymerase chain reaction (RT-PCR). Positive samples were further characterised to determine the subtypes and lineages of influenza viruses.
A total of 862 swabs were collected and tested. Twenty-three per cent of samples tested positive for influenza A and B viruses. Characterisation of positive specimens identified influenza A/H1N1pmd09 (2.5%), influenza A/H3N2 (57.3%), influenza B/Victoria lineage (36.7%) and 7 (3.5%) influenza B with undetermined lineage. Influenza B virus activity clustered in August through November while influenza A/H3N2 displayed two clusters of activities that appeared in May through August and November through December.
For the first time in Guinea, the epidemiology, diversity and period of circulation of influenza viruses were studied. The results indicate the predominance and the periods of activities of influenza B Victoria lineage and influenza A/H3N2 which are important information for preventive strategies. It is warranted to extend the influenza surveillance to other parts of Guinea to better understand the epidemiology of the viruses and monitor the emergence of influenza strains with pandemic potential.
ORDERS OF GROWTH AND GENERALIZED ENTROPY
Authors: Correa Javier , Pujals Enrique R. 
Published: September 2021

AbstractWe construct the complete set of orders of growth and define on it the generalized entropy of a dynamical system. With this object, we provide a framework wherein we can study the separation of orbits of a map beyond the scope of exponential growth. We show that this construction is particularly useful for studying families of dynamical systems with vanishing entropy. Moreover, we see that the space of orders of growth in which orbits are separated is wilder than expected. We achieve this with different types of examples.
Fetal Hemodynamic Responses to Arterial Occlusion of Acardiac Twins
Authors: Traisrisilp Kuntharee , Luewan Suchaya , Tongprasert Fuanglada , Srisupundit Kasemsri , Tongsong Theera 
Published: September 2021

AbstractThe objective of this study was to comprehensively assess fetal hemodynamic adaptions to occlusive procedures. Twin pregnancies complicated with acardiac twin and hydrops fetalis of the pump twin were recruited. The occlusive procedures — either alcoholization, radiofrequency ablation, coil embolization or occlusive glue — were performed under ultrasound guidance. Various hemodynamic parameters were assessed before, shortly after, then every 6 h for 48 h and 2−4 weeks after the procedures. Seven pregnancies were recruited. The median (range) gestational age of intervention was 21 (17−26) weeks of gestation. Before the procedures, all cases showed normal cardiac function. Just after the procedures, all cases showed an increase in Tei index and isovolumic relaxation time but returned to preocclusion levels within 6−48 h, except for two cases that were persistently high. Increased preload and poor shortening fraction were observed in two cases, leading to heart failure, with one recovery and one death in utero. Five out of the seven cases got through the critical period with a gradual return to normal hemodynamics, ending with the disappearance of hydrops and successful outcomes. It was concluded that the occlusive procedure could aggravate the overworked heart, leading to heart failure. Preocclusion preload index and Tei index may predict risk of heart failure due to the occlusion. This small series strongly suggests that the occlusion should be performed before the deterioration of cardiac function.
Dissolution Hotspots in Fractures
Authors: Hu Ran , Wang Ting , Yang Zhibing , Xiao Yang , Chen Yi‐Feng , Zhou Chuang‐Bing 
Published: September 2021

AbstractThe injection of reactive fluid into fractured reservoirs is relevant to many subsurface processes. During injection, fracture dissolution forms various patterns. Despite its importance, the evolution of geometries in radial fractures remains unexplored experimentally. Here, by flow‐visualization experiments, we characterize dissolution patterns and show that the patterns shift from compact to wormhole to uniform as flow rate increases. For the first time, we observe dissolution hotspots with maximum local dissolution rate in radial fractures, occurring at a distance from the inlet. We elucidate the key role of gravity for the occurrence of hotspots. The locations of hotspots correspond to the state that the effects of transport in the horizontal and vertical directions are comparable. We establish a theoretical model for predicting locations of hotspots in good agreement with experiments. This work demonstrates transitions of dissolution patterns in fractures and reveals the underlying mechanism for dissolution hotspots previously unidentified.
Prostate cancer castrate resistant progression usage of non-canonical androgen receptor signaling and ketone body fuel
Authors: Labanca Estefania , Bizzotto Juan , Sanchis Pablo , Anselmino Nicolas , Yang Jun , Shepherd Peter D. A. , Paez Alejandra , Antico-Arciuch Valeria , Lage-Vickers Sofia , Hoang Anh G. , Tang Ximing , Raso Maria Gabriela , Titus Mark , Efstathiou Eleni , Cotignola Javier , Araujo John , Logothetis Christopher , Vazquez Elba , Navone Nora , Gueron Geraldine 
Published: September 2021

AbstractProstate cancer (PCa) that progresses after androgen deprivation therapy (ADT) remains incurable. The underlying mechanisms that account for the ultimate emergence of resistance to ADT, progressing to castrate-resistant prostate cancer (CRPC), include those that reactivate androgen receptor (AR), or those that are entirely independent or cooperate with androgen signaling to underlie PCa progression. The intricacy of metabolic pathways associated with PCa progression spurred us to develop a metabolism-centric analysis to assess the metabolic shift occurring in PCa that progresses with low AR expression. We used PCa patient-derived xenografts (PDXs) to assess the metabolic changes after castration of tumor-bearing mice and subsequently confirmed main findings in human donor tumor that progressed after ADT. We found that relapsed tumors had a significant increase in fatty acids and ketone body (KB) content compared with baseline. We confirmed that critical ketolytic enzymes (ACAT1, OXCT1, BDH1) were dysregulated after castrate-resistant progression. Further, these enzymes are increased in the human donor tissue after progressing to ADT. In an in silico approach, increased ACAT1, OXCT1, BDH1 expression was also observed for a subset of PCa patients that relapsed with low AR and ERG (ETS-related gene) expression. Further, expression of these factors was also associated with decreased time to biochemical relapse and decreased progression-free survival. Our studies reveal the key metabolites fueling castration resistant progression in the context of a partial or complete loss of AR dependence.
Mutant collagen COL11A1 enhances cancerous invasion
Authors: Lee Carolyn S. , Siprashvili Zurab , Mah Angela , Bencomo Tomas , Elcavage Lara E. , Che Yonglu , Shenoy Rajani M. , Aasi Sumaira Z. , Khavari Paul A. 
Published: September 2021

AbstractCollagens are the most abundant proteins in the body and comprise the basement membranes and stroma through which cancerous invasion occurs; however, a pro-neoplastic function for mutant collagens is undefined. Here we identify COL11A1 mutations in 66 of 100 cutaneous squamous cell carcinomas (cSCCs), the second most common U.S. cancer, concentrated in a triple helical region known to produce trans-dominant collagens. Analysis of COL11A1 and other collagen genes found that they are mutated across common epithelial malignancies. Knockout of mutant COL11A1 impairs cSCC tumorigenesis in vivo. Compared to otherwise genetically identical COL11A1 wild-type tissue, gene-edited mutant COL11A1 skin is characterized by induction of β1 integrin targets and accelerated neoplastic invasion. In mosaic tissue, mutant COL11A1 cells enhanced invasion by neighboring wild-type cells. These results suggest that specific collagens are commonly mutated in cancer and that mutant collagens may accelerate this process.
Codon optimality in cancer
Authors: Gillen Sarah L. , Waldron Joseph A. , Bushell Martin 
Published: September 2021

AbstractA key characteristic of cancer cells is their increased proliferative capacity, which requires elevated levels of protein synthesis. The process of protein synthesis involves the translation of codons within the mRNA coding sequence into a string of amino acids to form a polypeptide chain. As most amino acids are encoded by multiple codons, the nucleotide sequence of a coding region can vary dramatically without altering the polypeptide sequence of the encoded protein. Although mutations that do not alter the final amino acid sequence are often thought of as silent/synonymous, these can still have dramatic effects on protein output. Because each codon has a distinct translation elongation rate and can differentially impact mRNA stability, each codon has a different degree of ‘optimality’ for protein synthesis. Recent data demonstrates that the codon preference of a transcriptome matches the abundance of tRNAs within the cell and that this supply and demand between tRNAs and mRNAs varies between different cell types. The largest observed distinction is between mRNAs encoding proteins associated with proliferation or differentiation. Nevertheless, precisely how codon optimality and tRNA expression levels regulate cell fate decisions and their role in malignancy is not fully understood. This review describes the current mechanistic understanding on codon optimality, its role in malignancy and discusses the potential to target codon optimality therapeutically in the context of cancer.
Real-world outcomes of combined therapy of photodynamic therapy with anti-vascular endothelial growth factor for polypoidal choroidal vasculopathy
Authors: Liu Siyin , Chhabra Ramandeep 
Published: September 2021

Abstract
Objectives
To describe the real-world outcomes of photodynamic therapy (PDT) as a rescue therapy in eyes with polypoidal choroidal vasculopathy (PCV) refractory to anti-vascular endothelial growth factor (VEGF) monotherapy in a British cohort of patients.

Methods
This is a retrospective chart review of 53 eyes with PCV. Based on the timing of PDT, the eyes were stratified into two groups (9 in the Initial-PDT group, 44 in the Deferred group). The number of anti-VEGF injections/year and the best corrected visual acuity (BCVA) before and after PDT were analysed. Multivariate regression model was created to identify factors predictive of visual outcome and treatment burden after PDT.

Results
The Deferred group received a mean of 9.4 injections/year but significantly reduced to 7.2 after PDT (p < 0.001). The Initial-PDT group required significantly fewer injections after PDT compared to the Deferred group (p = 0.004). The Deferred group experienced improvement in BCVA from 58.7 letters at baseline to 63.8 at 18-months follow-up (p < 0.001), but no significant increase was observed in the Initial-PDT group (p = 0.310). Better baseline BCVA is associated with higher likelihood of achieving good BCVA ≥ 70 letters after PDT (Odd Ratio=1.12, 95% CI: 1.03–1.21, p = 0.006), while increased number of anti-VEGF injections/year before PDT reduces the likelihood of easing treatment burden to ≥12 weeks apart between each injection after PDT (Odd Ratio=0.724, 95% CI: 0.58–0.91, p = 0.006).

Conclusions
PDT as a rescue therapy is beneficial in the long-term management of PCV, particularly in eyes that had experienced a significant period of prior exposure to anti-VEGF monotherapy.
Genetic purging in captive endangered ungulates with extremely low effective population sizes
Authors: López-Cortegano Eugenio , Moreno Eulalia , García-Dorado Aurora 
Published: September 2021

AbstractInbreeding threatens the survival of small populations by producing inbreeding depression, but also exposes recessive deleterious effects in homozygosis allowing for genetic purging. Using inbreeding-purging theory, we analyze early survival in four pedigreed captive breeding programs of endangered ungulates where population growth was prioritized so that most adult females were allowed to contribute offspring according to their fitness. We find evidence that purging can substantially reduce inbreeding depression in Gazella cuvieri (with effective population size Ne = 14) and Nanger dama (Ne = 11). No purging is detected in Ammotragus lervia (Ne = 4), in agreement with the notion that drift overcomes purging under fast inbreeding, nor in G. dorcas (Ne = 39) where, due to the larger population size, purging is slower and detection is expected to require more generations. Thus, although smaller populations are always expected to show smaller fitness (as well as less adaptive potential) than larger ones due to higher homozygosis and deleterious fixation, our results show that a substantial fraction of their inbreeding load and inbreeding depression can be purged when breeding contributions are governed by natural selection. Since management strategies intended to maximize the ratio from the effective to the actual population size tend to reduce purging, the search for a compromise between these strategies and purging could be beneficial in the long term. This could be achieved either by allowing some level of random mating and some role of natural selection in determining breeding contributions, or by undertaking reintroductions into the wild at the earliest opportunity.
Inhibition of serotonergic signaling induces higher consumption of both sucrose solution and toxic baits in carpenter ants
Authors: Josens Roxana , Giacometti Alina , Giurfa Martin 
Published: September 2021

AbstractBiogenic amines play an important role in the regulation of appetitive responses in insects. Among them, serotonin (5-HT) regulates feeding-related processes in numerous insect species. In carpenter ants, 5-HT administration has been shown to depress feeding behavior, thus opening the possibility of using 5-HT modulation in control strategies against those species considered as pest. Here we studied if administration of a 5-HT antagonist, ketanserin, promotes feeding of a sucrose solution and a toxic bait in carpenter ants Camponotus mus. We found that 3 h after a single oral administration of ketanserin, the mass of sucrose solution consumed by carpenter ants increased significantly. A similar effect was found after a chronic administration that lasted 5 days. Yet, ketanserin did neither affect the intake rates nor the activity of the pharyngeal pump that mediates feeding dynamics. In addition, ketanserin promoted the consumption of a toxic bait based on boric acid. Our results thus show that feeding motivation and consumption of both sucrose solution and a toxic bait can be enhanced via prior administration of ketanserin. We discuss the possible mechanisms underlying these effects and conclude that understanding basic physiological and neural principles that underlie feeding motivation allows establishing more efficient control strategies for pest insects.
Sarcopenia adversely impacts postoperative complications in living-donor liver transplantation recipients
Authors: Wu Mei-Yun , Lim Wei-Xiong , Cheng Yu-Fan , Chang Ching-Di , Hsu Hsien-Wen , Lin Chih-Che , Chen Chao-Long , Chang Wan-Ching , Yu Chun-Yen , Tsang Leo Leung-Chit , Chuang Yi-Hsuan , Ou Hsin-You 
Published: September 2021

AbstractDespite technological and immunological innovations, living-donor liver transplant (LDLT) recipients still face substantial risk of postoperative complications. Sarcopenia is being recognized more and more as a biomarker that correlates with poor outcomes in surgical patients. The purpose of this study was to evaluate the relationship between sarcopenia and significant surgical complications in LDLT recipients. This retrospective review included patients who had received LDLT at our institute from 2005 to 2017. Sarcopenia was assessed using the psoas muscle index (PMI) in cross-sectional images. ROC curve analysis was used to determine the ability of PMI to predict postoperative complications. Correlations between major postoperative complications and sarcopenia were evaluated using regression analysis. A total of 271 LDLT recipients were included. No significant differences were found between PMI and major postoperative complications in male patients. Female recipients with major postoperative complications had significantly lower mean PMI values (P = 0.028), and the PMI cut-off value was 2.63 cm2/m2. Postoperative massive pleural effusion requiring pigtail drainage occurred more frequently in the sarcopenia group than in the non-sarcopenia group (P = 0.003). 1-, 3-, 5- and 10-year overall survival rates in female were significantly poorer in the sarcopenia group (n = 14) compared with the non-sarcopenia group (n = 108), at 92.9% versus 97.2%, 85.7% versus 95.4%, 85.7% versus 92.5% and 70.1 versus 82.0%, respectively (P = 0.041) and 94.6%, 89.9%, 85.9% and 78.5% in male patients. Sarcopenia is associated with a significantly higher risk of major postoperative complications in females. PMI and sarcopenia together are predictive of major postoperative complications and survival rates in female LDLT recipients.
Phenotypic plasticity and a new small molecule are involved in a fungal-bacterial interaction
Authors: Andrade-Domínguez Andrés , Trejo-Hernández Abigail , Vargas-Lagunas Carmen , Encarnación-Guevara Sergio 
Published: September 2021

AbstractNitrogen-fixing bacteria have been extensively studied in the context of interactions with their host plants; however, little is known about the phenotypic plasticity of these microorganisms in nonmutualistic interactions with other eukaryotes. A dual-species coculture model was developed by using the plant symbiotic bacterium Rhizobium etli and the well-studied eukaryote Saccharomyces cerevisiae as a tractable system to explore the molecular mechanisms used by R. etli in nonmutual interactions. Here, we show that the fungus promotes the growth of the bacterium and that together, these organisms form a mixed biofilm whose biomass is ~ 3 times greater and is more structured than that of either single-species biofilm. We found that these biofilm traits are dependent on a symbiotic plasmid encoding elements involved in the phenotypic plasticity of the bacterium, mitochondrial function and in the production of a yeast-secreted sophoroside. Interestingly, the promoters of 3 genes that are key in plant bacteria-interaction (nifH, fixA and nodA) were induced when R. etli coexists with yeast. These results show that investigating interactions between species that do not naturally coexist is a new approach to discover gene functions and specialized metabolites in model organisms.