bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case report: ABO discrepancy due to vancomycin complicating a transfusion reaction investigation
Authors: Gilbert D.M. , Domen R.E. 
Published: June 2021

Abstract
A 3-year old patient with acute myelogenous leukemia developed fever and chills during transfusion of packed red cells. A preliminary workup suggested that a group AB donor unit had been issued to a Group A patient. However, a discrepancy between the ABO group of the original donor unit segment (A) and blood taken from the IV tubing (AB) and the patient’s pre- and posttransfusion samples (A and AB, respectively) suggested another reason for the weak reactivity of some samples with anti-B. The patient’s chart revealed that vancomycin, reported to be a cause of non-immune agglutination of red cells, had been injected into the IV tubing one hour prior to transfusion. Further testing confirmed that the patient’s febrile response to transfusion was consistent with a nonhemolytic transfusion reaction and was unrelated to the drug-induced, pseudo ABO problem.
New g-C3N4/GO/MoS2 composites as efficient photocatalyst for photocathodic protection of 304 stainless steel
Authors: Zheng Hongai , Sun Xin , Liu Yue , Jiang Shuangyan , Wang Derui , Fan Yankun , Hu Lili , Zhang Daquan , Yao Weifeng , Zhang Lizhi 
Published: June 2021

Abstract
Photocathodic protection is an economical and environmental metal anticorrosion method. In this research, we successfully synthesized the g-C3N4/GO (15 wt%)/MoS2 catalytic materials by a facile hydrothermal method. The results show that the as-prepared g-C3N4/GO (15 wt%)/MoS2 composites prominently enhanced photocatalytic activities for the photocathodic protection of 304 stainless steel (SS) compared with the corresponding pristine g-C3N4 and MoS2. Notably, the AC impedance results demonstrated that the Rct value of 304 SS coupled with g-C3N4/GO (15 wt%)/MoS2 decreased to 35.66 Ω•cm2, which is 29 and 37 times lower than that of g-C3N4 and MoS2 alone. In addition, g-C3N4/GO (15 wt%)/MoS2 provided the highest current density (77.19 μA•cm2) for the 304 SS, which is four times that of pristine g-C3N4. All results indicate that as-prepared g-C3N4/GO (15 wt%)/MoS2 photocatalysts have produced a distinct enhancement on photocathodic protection performance. An optimum decorating amount of MoS2 onto g-C3N4 forms heterojunctions of g-C3N4/MoS2, which favor the separation of electrons and holes efficiently. Furthermore, the addition of GO further promotes the separation and transfer of photo-induced carriers.
Zinc Oxide Nanoparticles as a Potential Agent for Antiviral Drug Delivery
Development: A Systematic Literature Review
Authors: Nasrollahzadeh Mahda S. , Ghodsi Razieh , Hadizadeh Farzin , Maleki MahdiFaal , Mashreghi Mohammad , Poy Donya 
Published: June 2021

:
Viral infection is a worldwide health problem, which has negatively affected global activity
in recent years. There is no specific medication for most of the viral infections and the treatments
are based on symptom management. Nanoparticles (NPs) in recent years have shown promising antibacterial
and antiviral properties, among which metal oxide NPs have shown superiority. In the present
study, we aimed to systematically review all available literature supporting the efficiency of zinc
oxide (ZnO)NPs in the treatment of viral infections. For this purpose, a systematic literature search
was performed in scientific literature databases, including PubMed, Scopus, Web of Science, Science
Direct, Ovid, Embase, and Google Scholar by using “viral infections”, “antiviral effects” and “ZnO
NPs” in addition to all their equivalent terms as keywords. Due to the lack of human studies, no strict
inclusion criteria were defined and all available relevant studies were included. A total of 14 documents
that fully met the inclusion criteria were retrieved and used for data synthesis. The results
showed that ZnO NPs due to specific physicochemical properties can be a promising approach in
developing antiviral agents and nano vaccines, especially against RNA viruses, such as human immunodeficiency
virus (HIV) and severe acute respiratory syndrome coronavirus. The most probable
antiviral mechanistic pathways of ZnO NPs include blocking the virus entry into the cells and deactivation
of the virus through virostatic potential. Based on the findings of the included studies, it is
suggested that ZnO NPs and other metal oxide-based NPs may be potential antiviral agents; however,
further human studies are required to confirm such efficiency in clinical practice.
The Plasma Levels of hsa-miR-19b-3p, hsa-miR-125b-5p, and hsamiR- 320c in Patients with Asthma, COPD and Asthma-COPD Overlap Syndrome (ACOS)
Authors: Bersimbaev Rakhmetkazhy , Aripova Akmaral , Bulgakova Olga , Kussainova Аssya , Akparova Almira , Izzotti Alberto 
Published: June 2021

Background:
Bronchial Asthma (BA) and Chronic Obstructive Pulmonary Disease
(COPD) are chronic airway inflammation diseases. In recent years, patients with signs of both BA
and COPD have been assigned to a separate group as Asthma-COPD Overlap Syndrome (ACOS).
Free-circulating plasma microRNAs are considered as potential biomarkers of pulmonology diseases,
including BA, COPD, and ACOS.

Objective:
This study aimed to investigate the expression level of free-circulating plasma microRNAs,
hsa-miR-19b-3p, hsa-miR-125b-5p, and hsa-miR-320c in patients with BA, COPD and
ACOS for the detection and validation of new microRNAs as biomarkers for chronic lung diseases.

Methods:
The relative expression levels of 720 microRNAs were evaluated by Real Time-Polymerase
Chain Reaction (RT-PCR) in patients with COPD and BA. Three upregulated microRNAs
(hsa-miR-19b-3p, hsa-miR-125b-5p and hsa-miR-320c) were selected for further study. The obtained
data were analyzed using the microRNA PCR Array Data Analysis tool. The sensitivity and
specificity were estimated using the area under the Receiver Operating Characteristics curve
(ROC).

Results:
The expression level of free-circulating hsa-miR-19b-3p was decreased in the blood plasma
of patients with BA and ACOS, and increased in patients with COPD. hsa-miR-125b-5p was
downregulated in the blood plasma of patients with COPD and upregulated in patients with BA
and ACOS. hsa-miR-320c was downregulated in the blood plasma of patients with BA, and upregulated
in patients with COPD and ACOS. The ROC curves of patients with BA for hsa-miR-19b-3p,
patients with ACOS for hsa-miR-125b-5p, and patients with COPD for hsa-miR-320c revealed the
probability of them as valuable biomarkers with AUCs of 0.824, 0.825, and 0.855, respectively.

Conclusion:
Our study revealed three promising biomarkers for the diagnosis of COPD, BA and
ACOS.
Evaluation of the Low Carb Program Digital Intervention for the Self-Management of Type 2 Diabetes and Prediabetes in an NHS England General Practice: Single-Arm Prospective Study
Authors: Summers Charlotte , Tobin Simon , Unwin David 
Published: June 2021

Background
Type 2 diabetes mellitus has serious health consequences, including blindness, amputation, and stroke. Researchers and clinicians are increasingly in agreement that type 2 diabetes may be effectively treated with a carbohydrate-reduced diet. Digital apps are increasingly used as an adjunct to traditional health care provisions to support remote self-management of long-term health conditions.

Objective
Our objective was to evaluate the real-world 12-month outcomes of patients prescribed the Low Carb Program digital health intervention at a primary care National Health Service (NHS) site. The Low Carb Program is a nutritionally focused, 12-session, digitally delivered, educational behavior change intervention for glycemic control and weight loss for adults with prediabetes and type 2 diabetes. The program educates and supports sustainable dietary changes focused on carbohydrate restriction by utilizing behavior change techniques, including goal setting, peer support, and behavioral self-monitoring, as well as personalized downloadable resources, including recipes and meal plans tailored to ethnicity, weekly shopping budget, and dietary preferences.

Methods
This study evaluated the real-world outcomes of patients recruited to the Low Carb Program at an NHS general practice in Southport, United Kingdom. All of the NHS patients recruited to the program were diagnosed with type 2 diabetes or prediabetes and were given access to the program at no cost. A total of 45 participants, with a mean age of 54.8 years (SD 13.2), were included in the study. Women made up 42% (19/45) of the sample. The mean hemoglobin A1c (HbA1c) of the sample was 56.7 mmol/mol (SD 16.95) and the mean body weight was 89.4 kg (SD 13.8).

Results
Of the 45 study participants recruited to the program, all of them (100%) activated their accounts and 37 (82%) individuals reported outcomes at 12 months. All 45 (100%) patients completed at least 40% of the lessons and 32 (71%) individuals completed more than nine out of 12 core lessons of the program. Glycemic control and weight loss improved, particularly for participants who completed more than nine core lessons in the program over 12 months. The mean HbA1c went from 58.8 mmol/mol at baseline to 54.0 mmol/mol, representing a mean reduction of 4.78 mmol/mol (SD 4.60; t31=5.87; P<.001). Results showed an average total body weight reduction of 4.17%, with an average weight reduction of 3.85 kg (SD 2.49; t31=9.27; P<.001) at the 12-month follow-up point.

Conclusions
A digital app prescribed to adults with type 2 diabetes and prediabetes in a primary care setting supporting a transition to a low-carbohydrate diet has been shown to be effective in improving glycemic control and enabling weight loss. Further research to understand more about factors affecting engagement with the app and further positive health implications would be valuable.
Risk Factors Associated with a Dengue Fever Outbreak in Islamabad, Pakistan: Case-Control Study
Authors: Mehmood Amjad , Khalid Khan Fawad , Chaudhry Ambreen , Hussain Zakir , Laghari Mumtaz Ali , Shah Ijaz , Baig Zeeshan Iqbal , Baig Mirza Amir , Khader Yousef , Ikram Aamer 
Published: June 2021

Background
On October 23, 2016, 79 dengue fever cases were reported from the Union Council Tarlai to Federal Disease Surveillance and Response Unit Islamabad. A team was established to investigate the suspected dengue outbreak.

Objective
The aim of this study was to determine the extent of the outbreak and identify the possible risk factors.

Methods
Active case finding was performed through a house-to-house survey. A case was defined as an acute onset of fever ≥38℃ in a resident of Tarlai from October 2 to November 11, 2016, with a positive dengue virus (nonstructural protein, NS-1) test and any of the two of following signs and symptoms: retroorbital/ocular pain, headache, rash, myalgia, arthralgia, and hemorrhagic manifestations. A structured questionnaire was used to collect data. Age- and sex-matched controls (1:1) were identified from residents in the same area as cases. Blood samples were taken and sent to the National Institute of Health for genotype identification.

Results
During the active case search, 145 cases of dengue fever were identified by surveying 928 houses from October 23 to November 11, 2016. The attack rate (AR) was 17.0/10,000. The mean age was 34.4 (SD 14.4) years. More than half of the cases were male (80/145, 55.2%). Among all cases, 29% belonged to the 25-34 years age group and the highest AR was found in the 35-44 years age group (35.6/10,000), followed by the 55-64 years age group (35.5/10,000). All five blood samples tested positive for NS-1 (genotype DENV-2). The most frequent presenting signs/symptoms were fever and headache (both 100%). Stagnant water around houses (odds ratio [OR] 4.86, 95% CI 2.94-8.01; P<.001), presence of flower pots in the home (OR 2.73, 95% CI 1.67-4.45; P<.001), and open water containers (OR 2.24, 95% CI 1.36-3.60; P<.001) showed higher odds among cases. Conversely, use of bed nets (OR 0.44, 95% CI 0.25-0.77; P=.003), insecticidal spray (OR 0.33, 95% CI 0.22-0.55; P<.001), door screens (OR 0.27, 95% CI 0.15-0.46; P<.001), mosquito coil/mat (OR 0.26, 95% CI 0.16-0.44; P<.001), and cleanliness of the house (OR 0.12, 95% CI 0.05-0.26; P<.001) showed significant protective effects.

Conclusions
Stagnant water acting as breeding grounds for vectors was identified as the probable cause of spread of the dengue outbreak. Establishment of surveillance and an early reporting system along with use of protective measures against the vector are strongly recommended.
Foundations of Modern Eurasianism in Russian Political Discourse
Authors: Lyubina D. E. 
Published: June 2021

The growing integration processes in the Eurasian space confirm the geopolitical place and role of this region in modern international relations. Thus it becomes more important to understand the basic postulates of the Eurasianism concept for the development of national and geopolitical interests of Russia, as well as to study the process of evolution of the main provisions of classical Eurasianism in the foundations of modern Russian neo-Eurasianism, as well as to determine the main stages of this process.The work is based on the analysis of publications of Russian neo-Eurasianism representatives, scientific works of foreign and domestic researchers of this phenomenon in the Russian political discourse.The geopolitical vector of the Eurasian concept is becoming the most relevant at the present stage in the context of increased interest in the geopolitical discourse and research of interaction, the “clash of civilizations”.For the modern Russian political discourse, the Eurasian theme has become one of the most promising foreign policy vectors. At present, we can observe how the theoretical concept of classic Eurasianism is reflected in Russia’s foreign policy. The Eurasian project began to be implemented from theory into political practice.
Law Enforcement of Waste Management in An Effort to Reduce Flood Risk in Indonesia
Authors: Azhar Azhar , Sobri Kgs Muhammad , Halim Abdul 
Published: June 2021

The aim of this paper is to identify law enforcement of waste management and formulate a law enforcement model for urban waste management in an effort to reduce flood risk. The explanatory survey was used in this study. Quantitative and qualitative approaches were used to explain the relationship between several variables. Sampling techniques were carried out in stages, and proportionally according to the research objectives. Besides, the data collection in this study carried out through observation, in-depth interviews, documentation and audio visual. The data analysis technique used descriptive qualitative through an interactive model developed by Miles and Huberman consisting of four interacting components, namely data collection, data reduction, data presentation and drawing conclusions and verification. Results indicate that there are some issues in law enforcement of waste management. First, the total number of law enforcers is not enough. Second, there are lack of facilities and infrastructures such as garbage cans, collection, temporary landfills, transportation and final processing. Third, there is a lack of commitment by the authorities in enforcing waste management laws related to reducing the risk of flooding. Furthermore, public awareness to comply with waste management is very law. Finally, there is still a lack of public awareness of the risk of flood. In conclusion, almost half of the community is aware that disposing of garbage in its place is very important for their survival and flood risk in their area. On the other hand, half of the people who do not care and still throw waste not properly
Rupturas e continuidades no pensamento de Arthur Neiva acerca da imigração japonesa no Brasil entre 1920 e 1937
Authors: Kubohira Ryo 
Published: June 2021

O presente artigo tem como objetivo analisar as rupturas e continuidades no discurso ora favorável, ora desfavorável do médico sanitarista, intelectual e político Arthur Neiva acerca da imigração japonesa para o Brasil entre 1920 e 1937. Ao longo do texto, abordaremos Ã s três fases do discurso de Neiva: um primeiro momento anti-japonês entre 1910 e 1920; um segundo momento no qual ele mesmo se autoproclamou pró-japonês após retornar de uma viagem científica ao Japão em janeiro de 1921. E, devido Ã s questões políticas que tangenciam o próprio espírito do Nacionalismo da década de 30, buscaremos apresentar, uma terceira fase no qual ele assume um papel conservador juntamente com outros líderes de vertente anti-japonês na Assembleia Nacional Constituinte de 1934. Assim, por meio do estudo de telegramas e jornais da época no Brasil e Japão, buscaremos compreender não apenas as “mudanças de lado” de Arthur Neiva, mas também, ao término, expor o próprio cerne do pensamento crítico sobre os imigrantes na Constituinte de 1934.
Utopia e destruição, ruína e progresso
Authors: Bisterço Vinícius da Cunha 
Published: June 2021

O filme A Margem, de Ozualdo Candeias, relata o cotidiano de quatro indivíduos moradores de uma região periférica da cidade de São Paulo. A partir das considerações de Marc Ferro, Eduardo Morettin e Ismail Xavier, o artigo elege caminhos para a mobilização do cinema como fonte do conhecimento histórico. Na investigação, principal ênfase se dá para a construção da experiência dos marginalizados, a qual aparece tensionada entre a constituição de vínculos de solidariedade e a incapacidade de reagirem coletivamente Ã s opressões. Além disso, o filme também é investigado como perspectiva crítica acerca do processo de modernização da cidade de São Paulo, intensificado a partir dos anos 50.
The Brazilian Financial System, Cyber Security Policy and Personal Data Protection
Authors: Goettenauer Carlos 
Published: June 2021

Purpose ”“ This work intends to map and analyze, through the polycentric regulation proposal introduced by Julia Black, the contribution of the actors involved in the creation of the data protection regulatory legal regime in financial system, after the introduction of the cyber security policy by the Central Bank of Brazil, the approval of the General Data Protection State and new financial business models.
Methodology ”“ It first analyses the regulatory and statutory norms associated with data protection in the financial system, combined with the cyber security policies published by financial institutions. After this, it identifies the actors who contribute to the regulatory environment and their respective regulatory role. The final step is the creation of a table to categorize each actor’s functions in the regulatory regime.
Findings ”“ The research concludes that the contracts between financial institutions and technology play a major role on creating and hybrid regulatory environment for data protection.
Originality ”“ The work is an original analysis of the data protection regulatory legal regime in financial system, using polycentric regulation not only as a theoretical reference, but also as a methodological framework.
Integrating general and local context-dependent factors into a framework for analysing business sectors in Bottom-of-the-Pyramid emerging markets
Authors: Broeksma Maaike , PENNINK Bart Jan Willem (Bartjan) 
Published: June 2021

Abstract:
Aim: This paper investigates how a framework for analysing business sectors in emerging markets looks like when taking into account the local context-dependent and general factors of The Bottom-of-the-Pyramid (BoP). The BoP segment in emerging markets represents a major growth potential for firms, including multinational enterprises (MNEs) from developed countries. However, the continued lack of success of MNEs in these markets has shown that generic one-size-fits-all strategies for the BoP are not appropriate as BoP contexts differ between countries.
Design / Research methods: The sample that was selected for the research includes two non-governmental organizations (NGOs) related to the BoP and eight managers at MNEs with activities in the BoP have been interviewed in a semi-structured manner to collect rich data.
Conclusion / findings: By interviewing eight managers at MNEs with activities in the BoP and two NGOs related to the BoP, an additional analysis, BoP-orientation, and further extensions to the original analyses are being presented. This results in an advanced framework for analysing business sectors in emerging markets.
Originality / value of the article: Current frameworks for analysing business sectors in emerging markets do take into account inter-country differences but fail to recognize intra-country differences, which causes them to fall short on their applicability to the BoP. This paper fills the gap how frameworks for analysing business sectors in emerging markets can be made applicable for the BoP by taking into account both the local context-dependent and general factors of a BoP-market to analyse it for opportunities, threats, and eventually and strategic entry mode.
Inteligencia emocional en estudiantes de la Carrera de Contabilidad y Auditoría de la Facultad de Ciencias Administrativas, Gestión Empresarial e Informática, Universidad Estatal de Bolívar y su influencia en el rendimiento académico
Authors: Gavilánez Cárdenas Clarita Vanessa , Llumiguano Poma María Elena , Chávez Chimbo Galo Wenseslao 
Published: June 2021

La investigación se fundamenta en evidenciar el tipo de Inteligencia Emocional-IE que tienen los estudiantes de la Carrera de Contabilidad y Auditoría de la Facultad de Ciencias Administrativas, Gestión Empresarial e Informática, de la Universidad Estatal de Bolívar-Ecuador para lo cual se ha tomado como muestra a 89 estudiantes, comprendidos entre el cuarto, quinto y sexto ciclo. Con la finalidad de determinar los niveles de inteligencia emocional y cómo influye su inteligencia emocional en el rendimiento académico, debemos acotar que hoy en día las realidades y estímulos resultan ser múltiples y complejos, los diferentes factores que podrían intervenir en los resultados académicos del estudiante y por ende en su deserción/permanencia en las universidades. En muchos de los casos los docentes observamos a diario que los estudiantes además de diferenciarse en su nivel académico, también difieren en sus habilidades emocionales. Mismas que influyen de forma decisiva en la adaptación psicológica de los alumnos en clase, en su bienestar emocional e, incluso, en sus logros académicos y en su futuro laboral, razón por lo cual debemos centrarnos más en esta línea de investigación y estudio que hace énfasis en el uso, comprensión y regulación de los estados de ánimo es el campo de estudio de la inteligencia emocional.
La mirada de la escuela a la interculturalidad: el cimiento de la ciudadanía
Authors: Ortega Velasco María Soledad 
Published: June 2021

Un total de noventa y un inmigrantes que han pasado por el sistema educativo español nos cuentan cómo ha sido su experiencia y para qué les ha servido la escuela. En base a esto se puede decir que es muy importante que la mirada en la escuela sea cercana, abierta a lo nuevo y con proyección de futuro, ya que en ella se educan hoy a los ciudadanos del mañana. El papel que en esta labor asume el docente es fundamental, por lo que deben incorporarse en su formación conceptos como el de hibridación cultural o el de pedagogía de la hibridación.