bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of multi-objective optimization on the basis of ratio analysis (MOORA) for selection of cotton fabrics for optimal thermal comfort
Authors: Mitra Ashis 
Published: July 2021

PurposeSelection of fabrics for particular purposy-e has created lots of research interest over the years, and the said problems have been addressed by several researchers using various multi-criteria decision-making (MCDM) methods. The main purpose of this paper is to highlight a maiden approach to handle one such fabric selection problem using multi-objective optimization by ratio analysis (MOORA) as a simple yet potent MCDM tool.Design/methodology/approachTwo approaches of MOORA method (namely, ratio system and reference point) have been demonstrated for ranking of 13 candidate fabrics based on four fabric attributes, namely, fabric cover, thickness, areal density and porosity.FindingsIn both the approaches, candidate fabric F3 secures rank 1 (the best alternative) whereas fabric F6 occupies rank 13 (the worst alternative). Moreover, ranking orders of these two approaches are alike and also show very high level of congruence with those of other approaches reported by earlier researchers, as evidenced from extremely high rank correlation coefficients (Rs > 0.89). During sensitivity analysis, each of the ranking results obtained from the four simulated weight sets do demonstrate very high degree of correlation (Rs > 0.90 for ratio system, andRs > 0.81 for reference point). Besides, no occurrence of rank reversal is observed even when the initial decision-making matrix is changed.Originality/valueMost the methods adopted so far for fabric selection purpose involve huge mathematical equations, complex computation and/or logic. The uniqueness of the MOORA method is that it involves minimal and thus very simple mathematical operations although possesses higher level of robustness and reliability.
Fault detection and diagnosis using vibration signal analysis in frequency domain for electric motors considering different real fault types
Authors: Ribeiro Junior Ronny Francis , Areias Isac Antônio dos Santos , Gomes Guilherme Ferreira 
Published: July 2021

Purpose
Electric motors are present in most industries today, being the main source of power. Thus, detection of faults is very important to rise reliability, reduce the production cost, improving uptime and safety. Vibration analysis for condition-based maintenance is a mature technique in view of these objectives.

Design/methodology/approach
This paper shows a methodology to analyze the vibration signal of electric rotating motors and diagnosis the health of the motor using time and frequency domain responses. The analysis lies in the fact that all rotating motor has a stable vibration pattern on health conditions. If the motor becomes faulty, the vibration pattern gets changed.

Findings
Results showed that through the vibration analysis using the frequency domain response it is possible to detect and classify the motors in several induced operation conditions: healthy, unbalanced, mechanical looseness, misalignment, bent shaft, broken bar and bearing fault condition.

Originality/value
The proposed methodology is verified through a real experimental setup.
Harmonious entrepreneurship – a new approach to the challenge of global sustainability
Authors: Kirby David Anthony , El-Kaffass Iman 
Published: July 2021

PurposeThe article is intended to consider how entrepreneurship needs to adapt if it is to address the global sustainability challenge. The intention is to propose a new business model that recognises the interconnectedness of the global ecosystem.Design/methodology/approachThe article analyses two case studies purposively written to demonstrate the difference between the traditional entrepreneurship approach, dating back to the 19th century and the proposed harmonised one. Both cases are based on secondary data and personal field observation.FindingsWhile the two cases focus on wealth creation, job generation and innovation, the traditional approach is shown to have had a long-term deleterious impact on both society and the environment, whereas the proposed harmonised approach impacts positively. The article recognises the multifaceted nature of the sustainability challenge and that the three elements (economy/commerce, society and environment) are interconnected. If there is a change in the status of one the other, connected facets will change or will need to be changed. Thus any solution needs to address all three facets.Social implicationsThe proposed business model will be of interest to scholars and practitioners of entrepreneurship and sustainability, as well as to policy makers and educators.Originality/valueApart from proposing a new business model that will address the sustainability challenge, the article provides a definition of harmonious entrepreneurship and identifies the conditions required for it to be met, as well as the characteristics of the harmonious entrepreneur.
A systematic review of video‐modelling interventions for children and adolescents with attention‐deficit hyperactivity disorder
Authors: Wilkes‐Gillan Sarah , Cordier Reinie , Chen Yu‐Wei , Swanton Ruth , Mahoney Natasha , Trimboli Concettina , Yule Elisa , Tam Elaine 
Published: July 2021

AbstractObjectiveTo identify, appraise, and synthesise the evidence for video‐modelling interventions for individuals with attention‐deficit hyperactivity disorder (ADHD).MethodWe searched four electronic databases. Two independent researchers screened abstracts and methodologically assessed data using the Kmet appraisal checklist.ResultsA total of 15 studies met the inclusion criteria (11 original studies and four follow‐up studies). Of the 11 original studies, one was a randomised controlled trial, one was a controlled between‐group comparative design, two were one group pre‐test post‐test studies, one was an experimental 2 × 2 factorial design, and six were single‐case experimental design studies. Studies included 1–35 participants with ADHD aged 5–16 years. Three studies targeted behaviour, three targeted social play skills, two targeted social behaviour, one targeted social skills, one targeted goal orientation and friendship quality, targeted and one attention/comprehension of social behaviour. In four studies video‐modelling was the whole intervention, with no other intervention components reported. Nine studies reported positive outcomes immediately after intervention, two studies reported mixed findings. All studies were found to have good or strong methodological quality.ConclusionThere is preliminary evidence to suggest video‐modelling may be a promising intervention approach for targeting the social skills and behaviours of individuals with ADHD when used in conjunction with other intervention components. Future studies need to lower the risk of bias and use larger sample sizes before the efficacy of video‐modelling interventions can be fully investigated.
Unilateral adrenalectomy for aldosterone‐producing adenoma in Hong Kong: Outcomes and factors predicting resolution of hypertension
Authors: Leung Hoi‐Tik , Yuen Wai‐Cheung , Lang Brian Hung‐Hin , Tan Kathryn Choon‐Beng , Fung Berry Tat‐Chow , Lau Emmy Yuen‐Fun , Ng Wai‐Kuen , Chan Kin‐Wah , Chan Bryant Shun‐Yan , Lau Ip‐Tim , Leung Jenny Yin‐Yan 
Published: July 2021

AbstractObjectiveTo evaluate surgical outcomes of patients with aldosterone‐producing adenoma (APA) over a 6‐year period from 2009 to 2014 in Hong Kong, and to derive a new scoring system to predict cure of hypertension after surgery.MethodologyThis was a retrospective multi‐centre study evaluating 104 APA patients from five major hospitals in Hong Kong. These patients were retrieved using database from Surgical Outcomes Monitoring and Improvement Programme (SOMIP). Their clinical characteristics and surgical outcomes were evaluated.ResultsOver a median follow‐up period of 5 years, APA patients who had undergone adrenalectomy had an average decrease in systolic and diastolic blood pressure of 16.9 and 4.8 mm Hg respectively. Cure of hypokalaemia, cure of hypertension and improvement in hypertension occurred in 100%, 48.5% and 40% respectively. When a patient had two of the following three parameters, namely, female sex, duration of hypertension ≤5 years and number of anti‐hypertensives ≤2, the sensitivity and specificity in achieving cure in hypertension was 79.6% and 70.6%, respectively. Surgical complications were uncommon.ConclusionsAdrenalectomy resulted in resolution of hypokalaemia for all and cure of hypertension in half of the patients with APA. It was safe and effective in curing hyperaldosteronism.
The impact of intensive care unit stay following oesophagectomy for oesophageal cancer on long‐term survival
Authors: Askari Alan , Wong Joshua , Rabinowitz Josh , Riaz Amjid 
Published: July 2021

AbstractAimSurvival in patients with oesophageal cancer is associated with an overall poor 5‐year survival rate. The aim of this study was to determine whether return to theatre, overall and intensive care unit (ICU) length of stay (LOS) impact long‐term survival.MethodsA single‐institution dataset of prospectively collated data from January 2011 to December 2018 were analysed. Survival analysis using multivariable Cox regression analyses were undertaken to determine factors associated with survival.ResultsA total of 190 patients underwent an oesophagectomy, of whom 81.6% (155/190) were male and the median age was 66 years (interquartile range 58‐72 years). The median length of stay was 12 days (interquartile range 10‐15 days). At a mean follow‐up of 36 months, 41.9% (117/279) of the population were deceased. Nodal, N3 staging [hazard ratio (HR) 5.30, 95% confidence interval (CI) 2.92‐9.63] was associated with poorer survival. Prolonged ICU stay of 5 to 7 days (HR 2.26, 95% CI 1.18‐4.33, P = .015), 8 to 10 days (HR 3.96, 95% CI 1.65‐9.50, P = .002) and over 10 days (HR 2.47, 95% CI 1.11‐5.47, P = .027) was also associated with significantly worse survival.ConclusionProlonged ICU stay after oesophagectomy has a negative impact on survival irrespective of the tumour stage. Enhanced recovery programs aimed at fast‐tracking ICU care and early safe patient discharge may improve long‐term survival.
Methodological threat or myth? Evaluating the current state of evidence on common method variance in human resource management research
Authors: Bozionelos Nikos , Simmering Marcia J. 
Published: July 2021

AbstractNew key evidence on common method variance (CMV) has been generated in the last decade (including quantitative and qualitative reviews, and simulations) to estimate its real validity threat, and evaluate the post hoc techniques to detect and correct for its effects. This work looks at the new evidence, and reviews all HRM‐related empirical articles published in the last 10 years in six major journals. The following primary conclusions are drawn. First, adoption of new knowledge about CMV by the empirical literature has been uneven. Second, published research in these journals indicates few incidences of meaningful distortion of estimates due to CMV, even when post hoc tests are used to detect it. Third, these findings in the empirical literature mirror the conclusions of reviews and simulations of the last 10 years, which indicate that the probability of significant distortion of estimates because of CMV is very limited.
R2Cross: A Web‐Based Decision Support Tool for Instream Flows
Authors: Oikonomou Panagiotis D. , Sidhu Rumpal , Wible Tyler , Morrison Ryan R. 
Published: July 2021

AbstractThe determination of instream flows for preserving or improving aquatic ecosystems’ health often includes challenges caused by varied hydraulic conditions, ecological criteria, and socioeconomic considerations. Despite the abundance of available methodologies, there are few available desktop or online applications enabling rapid assessment of instream flows that incorporate pertinent geospatial information for the region. We present R2Cross, a user‐friendly, online, instream flow rate calculation tool that was developed for aiding water allocation decisions in the state of Colorado. The R2Cross tool is the only existing online decision support tool based on a hydraulic rating method. It estimates hydraulic conditions at different water stages in a stream reach and compares them to habitat criteria to determine biological instream flow recommendations. Cloud‐based Geographic Information System features and additional tools are incorporated that augment information and aid in evaluating ecological needs. The development of the R2Cross tool enables an open‐access interface for management authorities and stakeholders to evaluate ecological needs at stream reaches. It automates the reporting process and could assist in making water management decisions about environmental protection. Although the R2Cross tool was developed for the state of Colorado, it is generalizable to other stream systems assuming similar habitat criteria.
A novel technique for a rare diagnosis: MRI‐guided vaginal biopsy of Skene gland adenocarcinoma: Pictorial Essay
Authors: Dentry Matt , McBean Rhiannon , Garrett Andrea , Brown Nicholas 
Published: July 2021

SummaryFDG‐PET and MRI imaging of the pelvis identified a suspicious lesion in a patient with a history of small cell neuroendocrine tumour of the vagina, and after a negative surgical biopsy, a multidisciplinary team meeting decided to proceed with MRGB (magnetic resonance‐guided biopsy). The patient remains well and in remission two years after anterior exenteration, with final histology of the lesion determined to be Skene gland adenocarcinoma. MRGB is a novel and effective way to diagnose vaginal lesions.
Durable response to EGFR tyrosine kinase inhibitors in a patient with non–small cell lung cancer harboring an EGFR kinase domain duplication
Authors: Hirokawa Esuteru , Watanabe Satomi , Sakai Kazuko , Takeda Masayuki , Sato Chihiro , Takahama Takayuki , Nishio Kazuto , Nakagawa Kazuhiko 
Published: July 2021

AbstractEpidermal growth factor receptor (EGFR) kinase domain duplication (KDD) has been identified as an oncogenic driver in 0.05% to 0.14% of non–small cell lung cancer (NSCLC) patients. However, little is known of the efficacy of EGFR tyrosine kinase inhibitors (TKIs) for such patients. Here, we report the case of a 45‐year‐old Japanese woman with NSCLC positive for EGFR‐KDD (duplication of exons 18–25) who developed carcinomatous meningitis and showed a marked response to the EGFR‐TKIs erlotinib and osimertinib. As far as we are aware, this is the first report of EGFR‐TKI efficacy for carcinomatous meningitis in a NSCLC patient harboring EGFR‐KDD.
Encouraging participation in colorectal cancer screening for people with schizophrenia: A randomized controlled trial
Authors: Fujiwara Masaki , Yamada Yuto , Shimazu Taichi , Kodama Masafumi , So Ryuhei , Matsushita Takanori , Yoshimura Yusaku , Horii Shigeo , Fujimori Maiko , Takahashi Hirokazu , Nakaya Naoki , Kakeda Kyoko , Miyaji Tempei , Hinotsu Shiro , Harada Keita , Okada Hiroyuki , Uchitomi Yosuke , Yamada Norihito , Inagaki Masatoshi 
Published: July 2021

AbstractObjectiveWe examined the efficacy of a case management approach to improve participation in colorectal cancer screening among people with schizophrenia.MethodsThis was a randomized, parallel group trial. We recruited outpatients with schizophrenia aged 40 years or over from two psychiatric hospitals in Japan. Participants were randomly assigned (1:1) to treatment as usual or case management intervention plus treatment as usual using a web‐based system. Attending clinicians and participants were unmasked to the allocation. Case management included education and patient navigation for colorectal cancer screening using a fecal occult blood test. Treatment as usual included direct mail government recommendations. The primary endpoint was participation in colorectal cancer screening assessed using municipal records. We also assessed the secondary endpoint of participation in other cancer screenings (lung, gastric, breast, and cervical).ResultsBetween 3 June and 9 September 2019, 172 eligible participants were randomly assigned to the case management plus treatment as usual group (n = 86) or treatment as usual group (n = 86). One participant was ineligible and another withdrew consent; both were excluded from analysis. A significantly higher proportion of participants received colorectal cancer screening in the case management plus treatment as usual group than in the treatment as usual group (40 [47.1%] of 85 participants vs. 10 [11.8%] of 85 participants, p < 0.0001). The proportion of lung cancer screening also increased. No serious adverse events associated with the study intervention occurred.ConclusionThe case management intervention to encourage participation in colorectal cancer screening was effective for patients with schizophrenia.
Molecular definition of severe acute respiratory syndrome coronavirus 2 receptor‐binding domain mutations: Receptor affinity versus neutralization of receptor interaction
Authors: Vogel Monique , Augusto Gilles , Chang Xinyue , Liu Xuelan , Speiser Daniel , Mohsen Mona O. , Bachmann Martin F. 
Published: July 2021

AbstractBackgroundSeveral new variants of SARS‐CoV‐2 have emerged since fall 2020 which have multiple mutations in the receptor‐binding domain (RBD) of the spike protein. It is unclear which mutations affect receptor affinity versus immune recognition.MethodsWe produced wild type RBD, RBD with single mutations (E484K, K417N, or N501Y) or with all three mutations combined and tested their binding to ACE2 by biolayer interferometry (BLI). The ability of convalescent sera to recognize RBDs and block their interaction with ACE2 was tested as well.ResultsWe demonstrated that single mutation N501Y increased binding affinity to ACE2 but did not strongly affect its recognition by convalescent sera. In contrast, single mutation E484K had almost no impact on the binding kinetics, but essentially abolished recognition of RBD by convalescent sera. Interestingly, combining mutations E484K, K417N, and N501Y resulted in a RBD with both features: enhanced receptor binding and abolished immune recognition.ConclusionsOur data demonstrate that single mutations either affect receptor affinity or immune recognition while triple mutant RBDs combine both features.
Standardisation of allergen products: 4. Validation of a candidate European Pharmacopoeia standard method for quantification of major grass pollen allergen Phl p 5
Authors: Zimmer Julia , Schmidt Sandra , Kaul Susanne , Costanzo Angèle , Buchheit Karl‐Heinz , Brown Shannon , Carnés Jerónimo , Chapman Martin , Chen Aaron , De Neergaard Michalade , Döring Sascha , Hindley James Phillip , Holzhauser Thomas , Jorajuria Sylvie , Le Tallec David , Lombardero Manuel , Iacovacci Patrizia , Reese Gerald , Sander Ingrid , Smith Bryan , Strecker Daniel , van Ree Ronald , Zebina Myriam , Vieths Stefan 
Published: July 2021

AbstractBackgroundThe aim of the BSP090 project is the establishment of European Pharmacopoeia Chemical Reference Substances (CRSs) in combination with corresponding standard ELISA methods for quantification of major allergens in allergen products. Here, we present data of a Phl p 5‐specific sandwich ELISA that proved suitable for the quantification of Phl p 5, one of the major Timothy grass (Phleum pratense) pollen allergens.MethodsA Phl p 5‐specific ELISA system was assessed with respect to accuracy, precision, inter‐assay (within laboratory) and inter‐laboratory variations, in a ring trial including 14 laboratories in Europe and the USA. Model samples containing recombinant Phl p 5a CRS as well as native grass pollen extracts were analysed. Each participant was instructed to perform at least one preliminary assay to familiarise with the protocol, followed by three independent assays.ResultsThe candidate standard ELISA proved suitable to quantify recombinant and native Phl p 5 with satisfactory precision (93% of results within ±30% acceptance range). Inter‐assay variation (max. GCV 24%) and especially inter‐laboratory variation (max. GCV 13%) showed conclusive results. When assessing accuracy by means of recovery of recombinant spikes from a grass pollen extract matrix, similarly satisfactory spike recovery results were observed for the two spikes with higher concentrations (all within ±30% acceptance range), whereas recovery of the lowest concentration spike was slightly poorer with mean results of six laboratories exceeding acceptance range.ConclusionsBased on the collaborative study results, the assessed Phl p 5‐specific immunoassay is appropriate to be proposed as European Pharmacopoeia standard method.
Safety, pharmacokinetics and quantitative EEG modulation of TAK‐071, a novel muscarinic M1 receptor positive allosteric modulator, in healthy subjects
Authors: Yin Wei , Mamashli Fahimeh , Buhl Derek L. , Khudyakov Polyna , Volfson Dmitri , Martenyi Ferenc , Gevorkyan Hakop , Rosen Laura , Simen Arthur A. 
Published: July 2021

AimsTAK‐071 is a muscarinic M1 receptor positive allosteric modulator designed to have low cooperativity with acetylcholine. This was a first‐in‐human study to evaluate the safety, pharmacokinetics, and pharmacodynamics of TAK‐071.MethodsTAK‐071 was administered as single and multiple doses in a randomized, double‐blind, placebo‐controlled, parallel‐group design in healthy volunteers alone and in combination with donepezil. Laboratory, electrocardiogram (ECG) and electroencephalogram (EEG) evaluations were performed. Cerebrospinal fluid and blood samples were taken to evaluate the pharmacokinetics (PK), relative bioavailability and food effect.ResultsTAK‐071 was safe and well tolerated, and no deaths or serious adverse events occurred. TAK‐071 demonstrated a long mean (% coefficient of variation) half‐life of 46.3 (25.2%) to 60.5 (51.5%) hours and excellent brain penetration following oral dosing. Coadministration with donepezil had no impact on the PK of either drug. There was no food effect on systemic exposure. Quantitative EEG analysis revealed that TAK‐071 40‐80 mg increased power in the 7‐9 Hz range in the posterior electrode group with eyes open and 120‐160 mg doses increased power in the 16‐18 Hz range and reduced power in the 2‐4 Hz range in central‐posterior areas with eyes open and eyes closed. Functional connectivity was significantly reduced after TAK‐071 at high doses and was enhanced with coadministration of donepezil under the eyes‐closed condition.ConclusionsPK and safety profiles of TAK‐071 were favorable, including those exceeding expected pharmacologically active doses based on preclinical data. When administered without donepezil TAK‐071 was largely free of cholinergic adverse effects. Further clinical evaluation of TAK‐071 is warranted.