bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of marital status with stage and survival in patients with mycosis fungoides: A population‐based study
Authors: Xing Ling‐Xiao , Zhang Jing , Shen Hui , Tang Xiao‐Lu , He Lu , Wu Jia‐Zhu , Li Jian‐Yong , Miao Yi 
Published: September 2021

AbstractBackgroundPrevious studies have shown that marital status was associated with stages and survival in patients with melanoma or Merkel cell carcinoma. To date, the impacts of marital status on stage and survival in patients with mycosis fungoides (MF) have not been determined yet.MethodsA total of 3375 eligible cases diagnosed from 2004 to 2015 were included from the Surveillance, Epidemiology, and End Results (SEER) database. Association of marital status with stage and survival in patients with MF was analyzed.ResultsMarried patients were more likely to be diagnosed at T1 stage (p = 0.041). And married patients were less likely to present with lymph node involvement (p = 0.007). More favorable overall survival (p < 0.001) and cancer‐specific survival (p < 0.001) were demonstrated in married patients as compared with divorced patients or widowed patients. A clinically feasible prognostic model including marital status, age, sex, race, and stage at presentation was constructed.ConclusionMarried marital status was associated with earlier stage at diagnosis and longer survival compared with divorced or widowed marital status in patients with MF.
Hearing loss and intellectual outcome in children treated for embryonal brain tumors: Implications for young children treated with radiation sparing approaches
Authors: Moxon‐Emre Iska , Dahl Christine , Ramaswamy Vijay , Bartels Ute , Tabori Uri , Huang Annie , Cushing Sharon L. , Papaioannou Vicky , Laperriere Normand , Bouffet Eric , Mabbott Donald J. 
Published: September 2021

AbstractPurposeWe investigate the impact of severe sensorineural hearing loss (SNHL) and for the first time evaluate the effect of unilateral versus bilateral SNHL on intellectual outcome in a cohort of children with embryonal brain tumors treated with and without radiation.MethodsData were from 94 childhood survivors of posterior fossa (PF) embryonal brain tumors who were treated with either: (1) chemotherapy alone (n = 16, 7.11 [3.41] years, 11M/5F), (2) standard‐dose craniospinal irradiation (CSI) and/or large boost volumes (n = 44, 13.05 [3.26] years, 29M/15F), or (3) reduced‐dose CSI with a boost restricted to the tumor bed (n = 34, 11.07 [3.80] years, 19M/15F). We compared intellectual outcome between children who: (1) did and did not develop SNHL and (2) developed unilateral versus bilateral SNHL. A Chang grade of ≥2b that required the use of a hearing aid was considered severe SNHL. Comparisons were made overall and within each treatment group separately.ResultsPatients who developed SNHL had lower full scale IQ (p = 0.007), verbal comprehension (p = 0.003), and working memory (p = 0.02) than patients without SNHL. No differences were observed between patients who had unilateral versus bilateral SNHL (all p > 0.05). Patients treated with chemotherapy alone who developed SNHL had lower mean working memory (p = 0.03) than patients who did not develop SNHL. Among patients treated with CSI, no IQ indices differed between those with and without SNHL (all p > 0.05).ConclusionsChildren treated for embryonal brain tumors who develop severe SNHL have lower intellectual outcome than patients with preserved hearing: this association is especially profound in young children treated with radiation sparing approaches. We also demonstrate that intellectual outcome is similarly impaired in patients who develop unilateral versus bilateral SNHL. These findings suggest that early intervention to preserve hearing is critical.
Contemporary post‐marketing adverse events and modes of failure related to VASCADE Vascular Closure System: The utility of the MAUDE database
Authors: Case Brian C. , Kumar Sant , Medranda Giorgio A. , Yerasi Charan , Forrestal Brian J. , Satler Lowell F. , Ben‐Dor Itsik , Hashim Hayder , Bernardo Nelson L. , Rogers Toby , Waksman Ron 
Published: September 2021

AbstractObjectivesTo analyze post‐marketing surveillance data from the United States Food and Drug Administration (FDA) Manufacturer and User Facility Device Experience (MAUDE) database for the VASCADE Vascular Closure System (Cardiva Medical Inc., Santa Clara, CA).BackgroundThe VASCADE Vascular Closure System is a closure device for femoral arterial and venous access‐site closure that was approved by the FDA in 2013. However, post‐marketing data and experience on the most commonly reported complications and modes of failure associated with the VASCADE Vascular Closure System are limited.MethodsPost‐marketing surveillance data from the FDA MAUDE database from October 2013 through March 2020 were analyzed, yielding 201 reports.ResultsOf the 201 reports of major complications involving VASCADE devices, 156 reports involved either injury (145) or death (11) related to the device. Of the 145 injury reports, bleeding was the most common adverse outcome described (85), followed by pseudoaneurysm (29) and pulselessness of an extremity (21). The device malfunction incidents (41 reports) were reported in three main categories, with deployment failure being the most commonly reported complication.ConclusionsOur analysis of the MAUDE database demonstrates that in contemporary post‐marketing practice, physicians should be well‐trained and educated to use the VASCADE closure device because improper utilization is a common cause of device failure, and complications with the VASCADE device can have profound clinical implications.
Low Temperature Sunlight‐Powered Reduction of CO2 to CO Using a Plasmonic Au/TiO2 Nanocatalyst
Authors: Martínez Molina Pau , Meulendijks Nicole , Xu Man , Verheijen Marcel A. , den Hartog Tim , Buskens Pascal , Sastre Francesc 
Published: September 2021

AbstractSunlight‐powered reduction of CO2 to fuels and chemicals is a promising strategy to close the carbon loop and facilitate the energy transition. In this research, we demonstrate that Au nanoparticles supported on TiO2 are an efficient plasmonic catalyst for the sunlight‐powered reverse water‐gas shift (rWGS) reaction. A maximum CO production rate of 429 mmol ⋅ gAu−1 ⋅ h−1 with a selectivity of 98 % and an apparent quantum efficiency of 4.7 % were achieved using mildly concentrated sunlight (1.44 W ⋅ cm−2 equals 14.4 sun). The CO production rate showed an exponential increase with increasing light intensity, suggesting that the process is mainly promoted by a photothermal effect. Thermal reference experiments with the same catalysts promoted CH4 formation, dropping the CO selectivity to 70 %. Thus, mildly concentrated sunlight can efficiently and selectively enhance the promotion of the rWGS reaction without using external heating.
Intracardiac versus transesophageal echocardiography for diagnosis of left atrial appendage thrombosis in atrial fibrillation: A meta‐analysis
Authors: He Guijun , Liu Hanxion , Huang Xiaoyu , Deng Xiaoqi , Yang Guosu , Luo Duan , Cai Lin 
Published: September 2021

AbstractIntroductionLeft atrial appendage (LAA) thrombus in patients with atrial fibrillation is usually detected by transesophageal echocardiography (TEE). Intracardiac echocardiography (ICE) can be a suitable alternative to detect thrombosis. However, the effectiveness of the two methods for detecting LAA thrombus is still unclear, we performed a meta‐analysis that compared ICE versus TEE for LAA thrombosis.MethodsWe searched PubMed, Cochrane Library, and Embase for published abstracts and manuscripts on June 1, 2020. The analysis was performed using RevMan 5.3, STATA 15, and Meta‐Disc 1.4.ResultsEight studies consists of 1108 patients (TEE = 558 vs. ICE = 550) were included. The average sensitivity of ICE and TEE to diagnose LAA thrombus is 1.0 (95% CI: 0.91–1.00) versus 0.68 (95% CI: 0.49–0.83), and specificity of ICE and TEE to diagnosis of LAA thrombus is 1.0 (95% CI: 0.99–1.00) versus 0.98 (95% CI: 0.96–0.99). The AUC of ICE and TEE is 0.9846 (SEAUC = 0.0196) and 0.9655 (SEAUC = 0.0401), and the Q* statistics is 0.9462 (SEQ* = 0.0406) and 0.9127 (SEQ * = 0.0616), respectively. Z test was performed on Q* statistics (Z = 0.45, p > .05).ConclusionThe ICE and TEE have similar diagnostic efficacy for LAA thrombosis, but the ICE has higher sensitivity. Compared with TEE, ICE may be more advantages and prospects for clinical application.
Using the lineage determinants Olig2 and Sox10 to explore transcriptional regulation of oligodendrocyte development
Authors: Sock Elisabeth , Wegner Michael 
Published: September 2021

AbstractThe transcription factors Olig2 and Sox10 jointly define oligodendroglial identity. Because of their continuous presence during development and in the differentiated state they shape the oligodendroglial regulatory network at all times. In this review, we exploit their eminent role and omnipresence to elaborate the central principles that organize the gene regulatory network in oligodendrocytes in such a way that it preserves its identity, but at the same time allows defined and stimulus‐dependent changes that result in an ordered lineage progression, differentiation, and myelination. For this purpose, we outline the multiple functional and physical interactions and intricate cross‐regulatory relationships with other transcription factors, such as Hes5, Id, and SoxD proteins, in oligodendrocyte precursors and Tcf7l2, Sip1, Nkx2.2, Zfp24, and Myrf during differentiation and myelination, and interpret them in the context of the regulatory network.
Potential geographical distribution and environmental explanations of rare and endangered plant species through combined modeling: A case study of Northwest Yunnan, China
Authors: Ye Pengcheng , Zhang Guangfu , Zhao Xiao , Chen Hui , Si Qin , Wu Jianyong 
Published: September 2021

AbstractIn recent decades, due to the effect of climate change and the interference of human activities, the species habitat index has fallen by 2%. Studying on the geographical distribution pattern and predicting the potential geographical distribution of species are of great significance for developing scientific and effective biodiversity conservation strategies. Plenty of rare and endangered species that need immediate conservation are distributed in Northwest Yunnan. In this regard, this research is conducted in the purpose of predicting the potential geographical distribution of 25 rare and endangered plant species in Northwest Yunnan and analyzing the explanation capabilities of various environmental factors on the potential geographical distribution patterns of these species. Initially, the ecological niche model MaxEnt was employed to predict the potential geographical distribution of target species. Following that, the superposition method was applied to obtain the potential geographical distribution pattern of species richness on the spatial scale of the ecological niche model with a resolution of 0.05° × 0.05°. Ultimately, geographically weighted regression (GWR) model was adopted to investigate the explanation capabilities of various environmental parameters on the potential distribution patterns. The research results showed that the average value of the area under the receiver operating curve (AUC) of each species was between 0.80 and 1.00, which indicated that the simulation accuracy of the MaxEnt model for each species was good or excellent. On the whole, the potential distribution area for each species was relatively concentrated and mainly distributed in the central‐western, central‐eastern and northern regions of Northwest Yunnan. In addition, the potential distribution areas of these species were between 826.33 km2 and 44,963.53 km2. In addition, the annual precipitation (Bio12), precipitation of coldest quarter (Bio19), and population density (Pop) made a greater contribution to the species distribution model, and their contribution values were 25.92%, 15.86%, and 17.95%, respectively. Moreover, the goodness‐of‐fit R2 and AIC value of the water model were 0.88 and 7,703.82, respectively, which indicated the water factor largely influenced the potential distribution of these species. These results would contribute to a more comprehensive understanding of the potential geographical distribution pattern and the distribution of suitable habitats of some rare and endangered plant species in Northwest Yunnan and would be helpful for implementing long‐term conservation and reintroduction for these species.
The quality of afterlife: surviving extracorporeal life support after therapy‐refractory circulatory failure—a comprehensive follow‐up analysis
Authors: Immohr Moritz Benjamin , Eschlböck Sophie Margaretha , Rellecke Philipp , Dalyanoglu Hannan , Tudorache Igor , Boeken Udo , Akhyari Payam , Albert Alexander , Lichtenberg Artur , Aubin Hug 
Published: September 2021

AbstractAimsExtracorporeal life support (ECLS) represents a popular treatment option for therapy‐refractory circulatory failure and substantially increases survival. However, comprehensive follow‐up (FU) data beyond short‐term survival are mostly lacking. Here, we analyse functional recovery and quality of life of longer‐term survivors.Methods and resultsBetween 2011 and 2016, a total of n = 246 consecutive patients were treated with ECLS for therapy‐refractory circulatory failure in our centre. Out of those, 99 patients (40.2%) survived the first 30 days and were retrospectively analysed. Fifty‐eight patients (23.6%) were still alive after a mean FU of 32.4 ± 16.8 months. All surviving patients were invited to a prospective, comprehensive clinical FU assessment, which was completed by 39 patients (67.2% of survivors). Despite high incidence of early functional impairments, FU assessment revealed a high degree of organ and functional recovery with more than 70% of patients presenting with New York Heart Association class ≤ II, 100% free of haemodialysis, 100% free of moderate or severe neurological disability, 71.8% free of moderate or severe depression, and 84.4% of patients reporting to be caring for themselves without need for assistance.ConclusionsPatients surviving the first 30 days of ECLS therapy for circulatory failure without severe adverse events have a quite favourable outcome in terms of subsequent survival as well as functional recovery, showing the potential of ECLS therapy for patients to recover. Patients can recover even after long periods of mechanically support and regain physical and mental health to participate in their former daily life and work.
Preferences on advance care planning and end‐of‐life care in patients hospitalized for heart failure
Authors: Kitakata Hiroki , Kohno Takashi , Kohsaka Shun , Fujisawa Daisuke , Nakano Naomi , Shiraishi Yasuyuki , Katsumata Yoshinori , Nagatomo Yuji , Yuasa Shinsuke , Fukuda Keiichi 
Published: September 2021

AbstractAimsEarly engagement in advance care planning (ACP) is recommended in heart failure (HF) management. We investigated the preferences of patients with HF regarding ACP and end‐of‐life (EOL) care, including their desired timing of ACP initiation.Methods and resultsData were collected using a 92‐item questionnaire survey, which was directly distributed to hospitalized patients by dedicated physicians and nurses in a university hospital setting. One‐hundred eighty‐seven patients agreed to participate (response rate: 92.6%), and 171 completed the survey [valid response rate: 84.7%; men: 67.3%; median age: 73.0 (63.0–81.0) years]. Logistic regression analyses were conducted to identify the predictors of positive attitudes towards ACP. Most recognized ACP as important for their care (n = 127, 74.3%), 48.1% stated that ACP should be initiated after repeated HF hospitalizations in the past year, and 29.0% preferred ACP to begin during the first or second HF hospitalization. Only 21.7% of patients had previously engaged in ACP conversations during HF management. Positive attitudes towards ACP were associated with lower depressive symptoms [two‐item Patient Health Questionnaire; odds ratio (OR): 0.75, 95% confidence interval (CI): 0.61–0.92, P‐value: 0.006], marriage (OR: 2.53, 95% CI: 1.25–5.12, P‐value: 0.010), and a high educational level (OR: 2.66, 95% CI: 1.28–5.56, P‐value: 0.009), but not with severity of HF (represented by Seattle Heart Failure Model risk score). Regarding EOL care, while ‘Saying what one wants to tell loved ones’ (83.4%), ‘Dying a natural death’ (81.8%), and ‘Being able to stay at one's favorite place’ (75.6%) were the three most important factors for patients, preferences for ‘Receiving sufficient treatment’ (56.5%) and ‘Knowing what to expect about future condition’ (50.3%) were divergent.ConclusionsDespite patients' preferences for ACP conversations, there was a discrepancy between preference and engagement in ACP among patients hospitalized for HF. Patients' preferences regarding EOL care may differ; physicians need to consider the appropriate ACP approach to align with patients' care goals.
Risks of trastuzumab‐related cardiotoxicity in breast cancer patients in Taiwan
Authors: Chang Wei‐Ting , Chen Po‐Wei , Lin Hui‐Wen , Lin Sheng‐Hsiang , Li Yi‐Heng 
Published: September 2021

AbstractAimsIn contrast to Western patients with breast cancer, Asian patients are relatively younger at diagnosis, and most are free from traditional cardiovascular risk factors. Despite trastuzumab‐related major adverse cardiac and cerebrovascular event (MACCE) being reported, its incidence and predictors remain unknown in Taiwan.Methods and resultsThrough a three‐hospital retrospective cohort study, we analysed the incidence of MACCE in 386 breast cancer patients' exposure to trastuzumab from 2010 to 2018. To further reconfirm our findings, in a nationwide study using the Taiwanese National Health Insurance Research Database and National Cancer Registry, we identified 13 502 women diagnosed with breast cancer who received chemotherapy from 2010 to 2015 and found 6751 women who received initial treatment with trastuzumab. After 1:1 propensity score matching with trastuzumab non‐users, the incidence of MACCE was measured with a median follow‐up of 36 months. In the hospital‐based study, among 386 patients receiving trastuzumab, the 5‐year incidences of MACCE and heart failure (HF) were 5.4 and 2.8%, respectively. In the national cohort, the crude incidences of MACCEs and HF were 4.67 and 3.21%, respectively. After adjustment for age and comorbidities, the hazard ratio of MACCE was 1.485 (95% CI 1.246–1.769). Notably, among the endpoints, only the hazard ratio of HF was significantly higher in patients receiving trastuzumab than in nonusers. In the subgroup analysis, except for patients also using taxanes, those receiving trastuzumab had a higher risk of MACCE than non‐users.ConclusionsFrom clinical observations in a nationwide cohort, we found an increased risk of MACCE, especially HF, in patients receiving trastuzumab. Given that its cardiotoxicity is independent of traditional cardiovascular risks, our findings highlight critical concerns regarding the cardiac safety of trastuzumab use.
Influence of baseline parameters on one‐year physical, mental, and health‐related quality of life in patients with heart failure and preserved ejection fraction
Authors: Fitz Judith , Edelmann Frank , Hasenfuß Gerd , Sandek Anja , Nolte Kathleen , Hashemi Djawid , Trippel Tobias D. , Wachter Rolf , Herrmann‐Lingen Christoph 
Published: September 2021

AbstractAimsTo identify baseline parameters longitudinally influencing overall health‐related quality of life (HRQoL), physical function and mental health 1 year later in patients with chronic heart failure and preserved ejection fraction (HFpEF).Methods and resultsWe performed post hoc analyses of the randomized aldosterone in diastolic heart failure (Aldo‐DHF) trial, including 422 patients with HFpEF and NYHA class II or III. Overall HRQoL, measured by the Minnesota Living with Heart Failure Questionnaire (MLHFQ), physical functioning and mental health, both measured by the Short Form 36 Health Survey (SF‐36), after 12 months were predicted in correlation analyses and multivariate regression analyses with continuous values and worst versus three better HRQoL quartiles as dependent variables. The mean age of the study population was 66.8 ± 7.6 years, 52.4% were female, and 86.0% had NYHA class II. All HRQoL variables at 1 year were predicted by their respective baseline values (all P < 0.001), which were also the best variables to predict lowest versus higher HRQoL quartiles (all P < 0.001). For overall HRQoL, six‐minute‐walking‐distance (P = 0.009), Borg‐score (P = 0.001), coronary heart disease (P = 0.036) and SF‐36 role‐emotional (P = 0.005) independently predicted one‐year‐outcome, while depression diagnosis (P = 0.044), self‐reported health status (P = 0.023) and PHQ depression (P = 0.001) were only significant predictors when excluding MLHFQ total score at baseline. In logistic regression analyses, only SF‐36 role‐emotional (P = 0.016) independently predicted overall HRQoL group status at follow up. For physical functioning, Borg‐score (P ≤ 0.001), 6 min walking distance (P = 0.005), coronary heart disease (P = 0.009), and SF‐36 vitality (P = 0.001) were significant independent predictors, also when excluding baseline physical functioning. Low SF‐36 vitality (P = 0.021) and presence of coronary heart disease (P = 0.027) independently predicted a patient's membership in the lowest quartile 1 year later. For mental health, SF‐36 physical functioning (P = 0.025) and HADS anxiety (P = 0.046) were independent predictors, while self‐rated fatigue and poor performance (P = 0.033) and SF‐36 vitality (P = 0.008) only served as significant predictors when excluding mental health at baseline. HADS anxiety (P = 0.009) also served as independent predictor of a patient's group status after 1 year.ConclusionOverall HRQoL, physical functioning, and mental health of HFpEF patients 1 year later are mainly influenced by their respective baseline values. Other self‐rated baseline parameters also showed independent effects while objective severity measures had limited predictive value.
Phenotyping heart failure patients for iron deficiency and use of intravenous iron therapy: data from the Swedish Heart Failure Registry
Authors: Becher Peter Moritz , Schrage Benedikt , Benson Lina , Fudim Marat , Corovic Cabrera Carin , Dahlström Ulf , Rosano Giuseppe M.C. , Jankowska Ewa A. , Anker Stefan D. , Lund Lars H. , Savarese Gianluigi 
Published: September 2021

AimsIron deficiency (ID) is associated with poor prognosis regardless of anaemia. Intravenous iron improves quality of life and outcomes in patients with ID and heart failure (HF) with reduced ejection fraction (HFrEF). In the Swedish HF registry, we assessed (i) frequency and predictors of ID testing; (ii) prevalence and outcomes of ID with/without anaemia; (iii) use of ferric carboxymaltose (FCM) and its predictors in patients with ID.Methods and resultsWe used multivariable logistic regressions to assess patient characteristics independently associated with ID testing/FCM use, and Cox regressions to assess risk of outcomes associated with ID. Of 21 496 patients with HF and any ejection fraction enrolled in 2017–2018, ID testing was performed in 27%. Of these, 49% had ID and more specifically 36% had ID−/anaemia−, 15% ID−/anaemia+, 29% ID+/anaemia−, and 20% ID+/anaemia+ (48%, 39%, 13%, 30% and 18% in HFrEF, respectively). Risk of recurrent all‐cause hospitalizations was higher in patients with ID regardless of anaemia. Of 1959 patients with ID, 19% received FCM (24% in HFrEF). Important independent predictors of ID testing and FCM use were anaemia, higher New York Heart Association class, having HFrEF, and referral to HF specialty care.ConclusionIn this nationwide HF registry, ID testing occurred in only about a quarter of the patients. Among tested patients, ID was present in one half, but only one in five patients received FCM indicating low adherence to current guidelines on screening and treatment.