bluuebunny/crossref_metadata_2025_split huggingface dataset:
Test Research on Air-conditioning Water Chiller of an Office Building
Authors: Yu Wenhong , Xu Weiwei , Li Hui 
Published: February 2021

Abstract
In this paper, an office building in Beijing is taken as the research object. This collected the operation data of the air-conditioning water chiller on a typical summer day. The performance of the air-conditioning water chilling unit and system is tested. This evaluates energy efficiency according to national standards and puts forward optimization suggestions. The results show that under low-load operation, the performance coefficient of the chiller reaches the detection index, but the efficiency of the air conditioning system is low. It is recommended to reduce the number of corresponding air conditioning equipment to optimize the performance coefficient of the air conditioning system. And the chiller can be installed a frequency conversion device to improve the operating performance of the chiller.
Polynomial to non-Darcian flow study
Authors: Deng Huilin , Li Lifeng 
Published: February 2021

Abstract
The theoretical modeling of fluid flow in low-permeability porous media is a common problem within engineering such as passages of fluid flow. Some factors lead the flow behaviors to deviate from the classical Darcy’s law. Therefore, it is of great scientific significance to carry out the research of non-Darcian flow and pecific analysis the fluid flow in porous media that do not satisfy the linear constitution law of flow. Compared with existing research results, this paper mainly shows that polynomials with powers of no more than 4 degrees have smaller mean squared errors (MSE) and higher correlation coefficients (R2) in experimental data.
Statistical Analysis and Study on Joint Distribution of the Extreme Value of Wind Speed and Wind Direction
Authors: Ye Tao , Li Lanlan 
Published: February 2021

Abstract
The joint distribution of wind speed and direction is one of basic characters of wind load, the distribution function at the location of building have to be acquired before structural wind resistance reliability analysis. In this paper, the joint probability distribution function was further studied based on previous references. An analytical method of joint probability density function of wind speed and wind direction from extreme value sample is proposed in this paper. By using this method, the probability distribution feature of any wind direction can be easily calculated which is of great benefits for safety and reliability analysis of wind-resistant structures. Then the joint probability of wind speed and direction near a civil structure was derived on the basis of datum sampled from weather station on the assumption that the wind direction and gradient wind speed of the weather station is same as that at location of the civil building. The data of wind speed and corresponding direction from Shanghai Baoshan weather stations were analysed as a case according to the method discussed in this paper. The conclusions in this paper is useful for analysis of reliability of structural wind resistance.
Development of remote hydraulic system based on BS framework
Authors: Song Wen Tao , Jin Jian , Li Xing Ke 
Published: February 2021

Abstract
Based on the analysis of related research at home and abroad, combined with the experimental requirements of hydraulic teaching and scientific research, this paper designs a remote teaching experiment project and content for hydraulic pump performance test based on B / s network architecture. The field experiment subsystem is designed and developed, and the field experiment measurement and control software is developed based on LabVIEW. The step responsetracking experiments in the field experiment and remote terminal experiment are compared and analyzed. The response speed and control accuracy of the remote terminal experimental system are slightly lower than that of the field experimental system, but both of the two systems can achieve good control of the controlled quantity, which can meet the needs of remote and field hydraulic experiments Using construction has an important role in promoting.
Analysis on the Influencing Factors and Prediction Sensitivity of the Initial Velocity of Gas Emission from Boreholes
Authors: Sun Bing-xing 
Published: February 2021

Abstract
The initial velocity of gas emission from boreholes is one of the main indicators for the prediction of the outburst hazard of the working face and the effect detection. Only by fully grasping the various factors affecting the initial velocity of gas emission from boreholes and continuously improving and perfecting the measurement method of the indicators can the test results be guaranteed, so that can accurately grasp the coal face outburst dangerous degree, thus improving the safety and reliability of prediction. In this paper, through the numerical analysis of the testing method of the initial velocity of gas emission from the borehole and the numerical analysis of the test results, various factors affecting the initial velocity of gas emission from the borehole are found, and the sensitivity of the prediction results of the initial velocity of gas emission from the borehole is further analyzed. Therefore, a technical way to improve the accuracy of the initial velocity of gas emission from the borehole was found. The analysis results show that the initial velocity of gas emission from boreholes is only suitable for coal seams or areas where the permeability of the coal seam is not small and changes little; when the gas pressure in the coal seam is small, the initial velocity of gas emission from boreholes is used to predict the geostress as the dominant factor The prominence of the prominence has poor prediction sensitivity; when measuring on site, the predicted borehole depth should enter the plastic deformation zone in the stress concentration zone, and high-quality and responsible test personnel should be assigned.
Carbon emission measurement analysis of prefabricated components in prefabricated buildings
Authors: Yang Hongxiong , Chen Junshu 
Published: February 2021

Abstract
In order to solve the problem of carbon emission of prefabricated building components, combined with the standardization results of prefabricated components in China, three calculation methods are put forward according to the availability of data, and the carbon emission database of standard prefabricated components is formed. And the standardization of prefabricated component design is extended to the standardization of carbon emission calculation. By calculation and analysis, the equations of the ratio of steel content to carbon emission per unit volume and carbon emission per unit volume of reinforced concrete are obtained. The proposed calculation method of carbon emissions is more simple and universal, and the analysis results can provide reference for related research.
Study on Mechanical and Thermal Expansion Properties of Oxide Coated Magnesium Borate Whiskers Reinforced Aluminum-based Composite
Authors: Zhang Lei , Zhang Mingming , Chen Zhongwei 
Published: February 2021

Abstract
The surface of magnesium borate whiskers was coated with oxide coatings of different components by chemical precipitation method, and magnesium borate whisker-reinforced aluminum-based composites were prepared by squeeze casting method. The compressive deformation resistance of the prefabricated whisker and the tensile and thermal expansion properties of the composite were tested. The experimental results show that the oxide coating can effectively improve the anti-deformation ability of the whisker preform, and the whisker preform prepared by MgO and Al2O3 coating has better strength, and the compressive strength at room temperature reaches 0.98 MPa and 0.96 MPa. The composite material prepared by Al2O3 coated whiskers has the highest room temperature tensile strength of 263 MPa, and the composite material prepared by ZnO coated whiskers has the lowest room temperature tensile strength of 224 MPa. The thermal expansion curve of the composite material shows that as the temperature increases, the thermal expansion coefficient of the composite material gradually increases, and the thermal expansion coefficient of the composite material decreases slightly after a temperature cycle.
Research on Parameters Setting of Smoke Exhaust Outlet and Cross Passage on Side Wall of Underwater Tunnel
Authors: Tian Fang , Chen Jianzhong , Lu Yi , Li Xing 
Published: February 2021

Abstract
In recent years, the length and scale of underwater road tunnels have continued to increase. Ventilation and fire prevention have become one of the key control factors for the successful construction and safe operation of underwater road tunnels. As one of the smoke extraction schemes of highway tunnel, determining the layout of sidewall smoke outlet is very important. In this paper, for the purpose of people being able to evacuate safely in a tunnel fire accident, taking an underwater tunnel as an engineering example, the available safe evacuation time (ASET) and the required safe evacuation time (RSET) under different working conditions are compared and analyzed by simulating the fire smoke spread and personnel evacuation process in the tunnel, so as to provide quantitative basis for the arrangement scheme of sidewall smoke outlet.
Practice and Teaching Reform of Engineering Geology for Urban Underground Space Engineering1
Authors: Junlan Zhao 
Published: February 2021

Abstract
Engineering geology is an important compulsory professional basis course for the urban underground space engineering. Its teaching hours is a few but rich in content. This course pays equal attention to theory and practice, whose teaching is difficult and endowed with challenging. In order to adapt to the deep, large and especial construction for urban underground space engineering, we must reform the practice and teaching system of engineering geology. The reformed course is closely combining with the construction practice of underground engineering and reflecting the latest academic achievements. We strengthen the practice and open teaching, focus on training students’ innovation ability and innovative thinking in the teaching process.
Quadriceps muscle group function and after total knee arthroplasty—asystematic narrative update
Authors: Morelli Ilaria , Maffulli Nicola , Brambilla Lorenzo , Agnoletto Marco , Peretti Giuseppe Maria , Mangiavini Laura 
Published: January 2021

AbstractBackgroundThis article systematically summarizes the present evidences, published in the last 20 years, regarding the pre- and post-operative factors, which may influence recovery of the function of the quadriceps muscle group following total knee arthroplasty (TKA). We following the PRISMA methodology, including meta-analyses and high-level evidence studies (prospective trials, and, when unavailable, retrospective studies).Sources of dataPubmed and Cochrane databases: 582 articles were identified and 54 of them were selected.Areas of agreementTourniquets inflated at high pressure exert a detrimental effect on the quadriceps muscle group. Faster quadriceps recovery takes place using mini-invasive approaches, an eight-week rehabilitation period including balance training and the use of nutraceuticals.Areas of disagreementPre-habilitation and pre-operative factors, analgesic methods and different TKA implants.Growing points and areas timely for developing researchTelerehabilitation seems a cost-effective tool for rehabilitation after TKA. Patients’ optimization protocols before TKA should include standardized nutraceuticals intake.
The VWF/LRP4/αVβ3-axis represents a novel pathway regulating proliferation of human vascular smooth muscle cells
Authors: Lagrange Jérémy , Worou Morel E , Michel Jean-Baptiste , Raoul Alexandre , Didelot Mélusine , Muczynski Vincent , Legendre Paulette , Plénat François , Gauchotte Guillaume , Lourenco-Rodrigues Marc-Damien , Christophe Olivier D , Lenting Peter J , Lacolley Patrick , Denis Cécile V , Regnault Véronique 
Published: February 2021

Abstract

Aims
Von Willebrand factor (VWF) is a plasma glycoprotein involved in primary haemostasis, while also having additional roles beyond haemostasis namely in cancer, inflammation, angiogenesis, and potentially in vascular smooth muscle cell (VSMC) proliferation. Here, we addressed how VWF modulates VSMC proliferation and investigated the underlying molecular pathways and the in vivo pathophysiological relevance.

Methods and results
VWF induced proliferation of human aortic VSMCs and also promoted VSMC migration. Treatment of cells with a siRNA against αv integrin or the RGT-peptide blocking αvβ3 signalling abolished proliferation. However, VWF did not bind to αvβ3 on VSMCs through its RGD-motif. Rather, we identified the VWF A2 domain as the region mediating binding to the cells. We hypothesized the involvement of a member of the LDL-related receptor protein (LRP) family due to their known ability to act as co-receptors. Using the universal LRP-inhibitor receptor-associated protein, we confirmed LRP-mediated VSMC proliferation. siRNA experiments and confocal fluorescence microscopy identified LRP4 as the VWF-counterreceptor on VSMCs. Also co-localization between αvβ3 and LRP4 was observed via proximity ligation analysis and immuno-precipitation experiments. The pathophysiological relevance of our data was supported by VWF-deficient mice having significantly reduced hyperplasia in carotid artery ligation and artery femoral denudation models. In wild-type mice, infiltration of VWF in intimal regions enriched in proliferating VSMCs was found. Interestingly, also analysis of human atherosclerotic lesions showed abundant VWF accumulation in VSMC-proliferating rich intimal areas.

Conclusion
VWF mediates VSMC proliferation through a mechanism involving A2 domain binding to the LRP4 receptor and integrin αvβ3 signalling. Our findings provide new insights into the mechanisms that drive physiological repair and pathological hyperplasia of the arterial vessel wall. In addition, the VWF/LRP4-axis may represent a novel therapeutic target to modulate VSMC proliferation.
Genetic contribution to high temperature tolerance in Cryptococcus neoformans
Authors: Stempinski Piotr R , Zielinski Jessica M , Dbouk Nadir H , Huey Elizabeth S , McCormack Ellen C , Rubin Alexander M , Chandrasekaran Srikripa , Kozubowski Lukasz 
Published: February 2021

Abstract
The human fungal pathogen Cryptococcus neoformans relies on a complex signaling network for the adaptation and survival at the host temperature. Protein phosphatase calcineurin is central to proliferation at 37°C but its exact contributions remain ill-defined. To better define genetic contributions to the C. neoformans temperature tolerance, 4031 gene knockouts were screened for genes essential at 37°C and under conditions that keep calcineurin inactive. Identified 83 candidate strains, potentially sensitive to 37°C, were subsequently subject to technologically simple yet robust assay, in which cells are exposed to a temperature gradient. This has resulted in identification of 46 genes contributing to the maximum temperature at which C. neoformans can proliferate (Tmax). The 46 mutants, characterized by a range of Tmax on drug-free media, were further assessed for Tmax under conditions that inhibit calcineurin, which led to identification of several previously uncharacterized knockouts exhibiting synthetic interaction with the inhibition of calcineurin. A mutant that lacked septin Cdc11 was among those with the lowest Tmax and failed to proliferate in the absence of calcineurin activity. To further define connections with calcineurin and the role for septins in high temperature growth, the 46 mutants were tested for cell morphology at 37°C and growth in the presence of agents disrupting cell wall and cell membrane. Mutants sensitive to calcineurin inhibition were tested for synthetic lethal interaction with deletion of the septin-encoding CDC12 and the localization of the septin Cdc3-mCherry. The analysis described here pointed to previously uncharacterized genes that were missed in standard growth assays indicating that the temperature gradient assay is a valuable complementary tool for elucidating the genetic basis of temperature range at which microorganisms proliferate.
Cohesin dysfunction results in cell wall defects in budding yeast
Authors: Kothiwal Deepash , Gopinath Swagathnath , Laloraya Shikha 
Published: February 2021

Abstract
Cohesin is a conserved chromatin-binding multisubunit protein complex involved in diverse chromosomal transactions such as sister-chromatid cohesion, chromosome condensation, regulation of gene expression, DNA replication, and repair. While working with a budding yeast temperature-sensitive mutant, mcd1-1, defective in a cohesin subunit, we observed that it was resistant to zymolyase, indicating an altered cell wall organization. The budding yeast cell wall is a strong but elastic structure essential for maintenance of cell shape and protection from extreme environmental challenges. Here, we show that the cohesin complex plays an important role in cell wall maintenance. Cohesin mutants showed high chitin content in the cell wall and sensitivity to multiple cell wall stress-inducing agents. Interestingly, temperature-dependent lethality of cohesin mutants was osmoremedial, in a HOG1-MAPK pathway-dependent manner, suggesting that the temperature sensitivity of these mutants may arise partially from cell wall defects. Moreover, Mpk1 hyper-phosphorylation indicated activation of the cell wall integrity (CWI) signaling pathway in cohesin mutants. Genetic interaction analysis revealed that the CWI pathway is essential for survival of mcd1-1 upon additional cell wall stress. The cell wall defect was independent of the cohesion function and accompanied by misregulation of expression of several genes having cell wall-related functions. Our findings reveal a requirement of cohesin in maintenance of CWI that is independent of the CWI pathway, and that may arise from cohesin’s role in regulating the expression of multiple genes encoding proteins involved in cell wall organization and biosynthesis.
Translating insights from the seed metabolome into improved prediction for lipid-composition traits in oat (Avena sativaL.)
Authors: Campbell Malachy T , Hu Haixiao , Yeats Trevor H , Caffe-Treml Melanie , Gutiérrez Lucía , Smith Kevin P , Sorrells Mark E , Gore Michael A , Jannink Jean-Luc 
Published: February 2021

AbstractOat (Avena sativa L.) seed is a rich resource of beneficial lipids, soluble fiber, protein, and antioxidants, and is considered a healthful food for humans. Little is known regarding the genetic controllers of variation for these compounds in oat seed. We characterized natural variation in the mature seed metabolome using untargeted metabolomics on 367 diverse lines and leveraged this information to improve prediction for seed quality traits. We used a latent factor approach to define unobserved variables that may drive covariance among metabolites. One hundred latent factors were identified, of which 21% were enriched for compounds associated with lipid metabolism. Through a combination of whole-genome regression and association mapping, we show that latent factors that generate covariance for many metabolites tend to have a complex genetic architecture. Nonetheless, we recovered significant associations for 23% of the latent factors. These associations were used to inform a multi-kernel genomic prediction model, which was used to predict seed lipid and protein traits in two independent studies. Predictions for 8 of the 12 traits were significantly improved compared to genomic best linear unbiased prediction when this prediction model was informed using associations from lipid-enriched factors. This study provides new insights into variation in the oat seed metabolome and provides genomic resources for breeders to improve selection for health-promoting seed quality traits. More broadly, we outline an approach to distill high-dimensional “omics” data to a set of biologically meaningful variables and translate inferences on these data into improved breeding decisions.
Is left ventricular superior to right ventricular pacing in children with congenital or postoperative complete heart block?
Authors: Siddharth Ch Bharat , Relan Jay 
Published: January 2021

Summary
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was ‘Is left ventricular superior to right ventricular pacing in children with congenital or postoperative complete heart block?’ Altogether, 19 papers were found using the reported search, of which 9 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. Two large multicentric showed that site of pacing was the major determinant of left ventricular (LV) function with LV pacing being superior to RV pacing, though the number of patients paced via LV was lesser in comparison to right ventricular (RV). There were 2 prospective, 2 retrospective and 1 cross-sectional studies with fewer patients that demonstrated superiority of LV over RV pacing in preserving LV function. Only 1 small-scale retrospective study showed similar results of LV and RV pacing on LV function. One cross-sectional study showed superiority of LV apical pacing on exercise tolerance. As per the existing literature, LV apex seems to be the most optimal site for epicardial pacing while RV free wall pacing has the highest risk of causing LV dysfunction over the long term. We conclude that LV pacing appears to be superior to RV pacing in terms of long-term effect on cardiac function and ventricular synchrony.
Research on feature of thermal performance of integrated composite system
Authors: Chen Lei , Li Yangluxi 
Published: February 2021

Abstract
The aim of this study is to explore the effect of stud on the characteristics of thermal insulation and decoration composite system. Prior research conducted has primarily focused on the insulation material performance aside from the composite system. The theoretical calculation and field measurement method are adopted in this paper to compare the insulation performance for different building envelope systems. By considering the thermal transfer coefficient as the performance indicator, thermal bridge and air cavities of integrated insulation composite system as impact factors are investigated. Firstly, the high insulation performance of the composite system is determined via comparing other systems. Secondly, the thermal bridge issue of the composite system led by stud is subsequently investigated followed by the air cavity influenced element being studied via field measurement, which is caused by stud condition. Final results indicate that the thermal insulation and decoration composite system can achieve a substantial insulation performance. In this case, the corresponding optimal size of studs and air cavity is achieved. Further, scattered layout of air cavities could apparently improve the entire thermal system’s insulated performance. All these studied conclusions can contribute designers to implement this system more accurately.