bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genotoxicity of PM2.5 and PM1.0 Particulates on Human Peripheral Blood Lymphocytes in Manila, Philippines
Authors: Estonilo Ma. Katrina Gale , Cazeñas Joedith Anne , Villafuerte Carlos Josef , Deocaris Custer , Caraos Gloriamaris , Robles Gerardo Jose , Galvez Maria Cecilia , Asaad Celia , Vallar Edgar 
Published: November 2021

Urban air quality is increasingly being studied as a fraction of the world's population is now living in megacities. In this study, particulate matter (PM) along Taft Avenue, Manila, Philippines, is investigated in terms of its ability to induce genetic damage on human peripheral blood lymphocytes (PBL). Size-segregated roadside air samples were obtained from 2015-2016 near the university gate and analyzed using in vitro micronucleus and cytokinesis-block proliferation tests. While cellular proliferation was unaffected by 0 – 0.1 kg·m-3 of PM1.0 and PM2.5, PBL cells treated with PM2.5 displayed significantly higher micronucleus count (p = 0.03) compared to the cells treated with PM1.0. Atomic Absorption Spectroscopy revealed greater amounts of Cd, Ca, Pb, K, Na, and Zn in PM2.5 compared to PM1.0. The results indicate the differences in composition of the two size fractions of air particulates are associated with their genotoxicities.
Internal continuatives and logical metaphors: A development of classifying conjunctive relation
Authors: Santosa Riyadi , Sumarlam  , Wiratno Tri , Priyanto Agus Dwi , Susanti Ratna 
Published: November 2021

This research attempts to develop Martin’s & Rose’s concept of conjunctive relation (CR) analysis, in which the external and internal roles of conjunction do not include the other two types of conjunctive relation markers such as continuative and logical metaphor. Relying on more than twenty international journal articles, the research findings exhibit that certain types of continuative and logical metaphor can not only operate externally to connect events and qualities but they can also function internally to organize evidences and arguments in texts. As a result, not only a new role of internal continuative and logical metaphor can be confirmed, but the findings will also introduce an elaborated development of classifying CR in general. The emergence of the internal role of continuative and logical metaphor leads to a more elaborate way of connecting and grouping clauses into different units of discourse. In this way, they will also be able to demonstrate how texts can be built up through clauses, phases, and stages in a particular genre, without the need to be interpreted in conjunctions.
HIGHLIGHTS:

This article attempt to find a new way of classifying internal and external conjunctive relation that is comprised of conjunction, continuative and metaphor. Martin (2007) argues that only conjunction that perform external and inter.
This article exhibits that actually external and internal roles can also be performed by continuative and metaphor
Alternatif Pendanaan Antara Leasing, Hutang Jangka Panjang dan Saham Biasa dalam Pengadaan Aktiva Tetap pada PT. Blue Bird Tbk
Authors: Bella Mei Mita , Amaniyah Evaliati 
Published: October 2021

In a business, fixed assets are very important for a company, fixed assets in the company are usually used as an investment for the long term. In addition, the most important thing in a company is fixed assets as a working capital for the survival of the company. The choice of financing alternatives will affect the decision making in the procurement of fixed assets. The purpose of this study is to determine which source of funding is the most efficient in the procurement of fixed assets among leasing, long term debt, and common stock capital at PT. Blue Bird Tbk in 2019. This study uses a descriptive research method that compare net present value of the three funding alternatives. The result of study shows that long-term debt has a smallest net present value compared to leasing and common stock capital so that it is most efficient when used in the procurement of fixed assets in PT. BIue Bird Tbk.
Pengaruh Gaya Hidup Halal, Label Halal Dan Harga Terhadap Keputusan Pembelian Ms Glow (Studi Pada Mahasiswi Universitas Trunojoyo Madura)
Authors: Hoiriyah Yuliana Ulfidatul , Chrismardani Yustina 
Published: October 2021

This study aims to see the effect of the halal lifestyle, the halal label, and the price of MS Glow’s product on the purchase decision of students of Trunojoyo Madura University from 2017 to 2020. Sampling in this study used accidental sampling with a total of 100 respondent, and analyzed using multiple linear regressions analysis. Based on the partial analysis, the result show, that each variables (halal lifestlye, halal label and price) has a significant effect on the purchase decision of MS Glow of the students of Trunojoyo Madura University.
ANALISIS PERBANDINGAN HARGA SAHAM DAN VOLUME PERDAGANGAN SAHAM SEBELUM DAN SESUDAH PENGUMUMAN COVID-19 DI INDONESIA (Studi Pada Indeks Saham LQ-45 Di Bursa Efek Indonesia)
Authors: Iswanti Aviana Putri , Susandini Aprilina 
Published: October 2021

The Covid-19 case in Indonesia was first announced on March 2, 2020. This study aims to determine whether there is a significant difference in share prices and share trading volume before and after the announcement of Covid-19 in Indonesia on LQ-45 shares on the Indonesia Stock Exchange. . The research data were taken 14 days before and 14 days after the announcement of the first case of Covid-19 in Indonesia. The data analysis was processed with descriptive statistics, the One Sample Kolmogorov-Smirnov Test, and the Wilcoxon Signed Rank Test. From the results of data processing, it shows that there is a significant difference in stock prices before and after the announcement of the first Covid-19 case in Indonesia. This is indicated by a significance value of 0.00 0.05. Where the share price has decreased compared to before the announcement of the Covid-19 case. Meanwhile, the trading volume of shares also shows a significant difference. Where the significance value is 0.00 0.05. The volume of stock trading after the announcement shows an increasing value.
ANALISIS STRATEGI BAURAN KOMUNIKASI PEMASARANDALAM MENINGKATKAN PENJUALAN SENJATA KERIS DIDESA AENG TONG – TONG SUMENEP
Authors: Albar Andi Barri , Suyono Suyono 
Published: October 2021

This study aims to determine what strategies are used to increase the sale of keris weapons in the village of Aeng Tong-Tong Sumenep. The research method used is descriptive qualitative, descriptive research aims to collect detailed information by describing the situation in the field, data obtained through interviews with researchers from informants. From the results of research that can be obtained that the marketing communication mix that has been used by businessmen in the village of Aeng Tong-Tong Sumenep currently is Advertising, Sales promotion, Event and experiences, Online and social media marketing,interactive marketing, Personal selling. With the marketing communication mix relatively increased compared to before using only conventional sales methods.
Pemahaman Konsep Geometri Anak Usia Dini pada Pembelajaran Berbasis STEAM
Authors: Sa'ida Naili 
Published: October 2021

Pemahaman konsep geometri pada anak penting untuk dikembangkan karena dalam kehidupan sehari-hari cenderung sering kita perlukan, melalui konsep geometri anak mampu mengembangkan kemampuan pemecahan masalah. Penelitian ini bertujuan untuk mengembangkan pemahaman konsep geometri anak usia dini melalui pembelajaran berbasis STEAM. Pendekatan penelitian yang digunakan dalam penelitian ini adalah pendekatan penelitian kuantitatif dengan desain pre experiment one group pretest posttest. Teknik pengumpulan data yang digunakan berupa observasi dan wawancara. Indikator dalam penelitian ini diantaranya: mengelompokkan bentuk geometri berdasarkan warnanya, pengelompokan geometri berdasarkan bentuk, pengelompokan geometri menurut ukuran, dan menyebutkan benda disekitar yang berbentuk geometri. Teknik analisis data menggunakan uji wilcoxon match pairs test. Hasil perhitungan menunjukkan nilai Thit sebesar 0 dan Ttab=3 dengan taraf signifikansi 5% dan N=10. Diketahui Thit≤ Ttab, sehingga disimpulkan bahwa model pembelajaran berbasis STEAM mampu mengembangkan pemahaman konsep geometri anak usia dini. Pengembangan geometri pada penelitian ini lebih pada inovasi model pembelajaran yang diterapkan yaitu dengan pembelajaran berbasis STEAM yang mampu membuat anak lebih aktif dalam pembelajaran. Saran untuk penelitian selanjutnya, dapat melakukan penelitian pengembangan pemahaman konsep geometri pada aspek lain dengan meningkatkan kualitas dari segi pelaksanaan atau media yang mampu mencapai hasil yang optimal.
Orbital cholesterol granuloma: a retrospective case series
Authors: Zhao Yun , Hui Jingwen , Yu Shasha , Lin Jinyong , Zhao Hong 
Published: November 2021

Abstract
Background
To review the clinical features, radiographic features, therapy, pathological features and prognosis of orbital cholesterol granuloma(CG).
Methods
Twelve patients with orbital CG who were referred to Tianjin Eye Hospital between January 2002 and December 2020 were include in this retrospective case series study. Data collected included patient ophthalmic manifestations, imaging finding, treatment strategies, pathological features and prognosis were retrospectively reviewed.
Results
The patients comprised 10 males and 2 females. The mean age was 34.5±8.9 years(range 16 to 45 years). Four patients had a history of orbital trauma. The clinical manifestations at first visit were proptosis ( 7/12, 58.3%), periorbital or eyelids swelling (6/12,50%), limitation of eye displacement (4/12,33.3%), ptosis(2/12,16.7%), decreased visual acuity (1/12,8.3%).CT showed a non-enhancing,well-circumscribed lesion in the orbit with extensive erosion of the adjacent frontal bone and temporal bone.MRI showed a non-enhancing mass with intermediate to high signal intensity on T1- and T2-weighted imaging. Ten patients underwent lateral orbitotomy, and two patient underwent supraorbital orbitotomy,.All patients had aggressive bone erosion. Histopathologic evaluation of the cyst contents and wall revealed cholesterol clefts,multinucleated giant cells,histiocytes, foamy macrophages,and altered blood pigments. The median recurrence time of 79.6±49.8 months (range 19 month to 193 months). Three patients were lost to follow-up. No postoperative diminution of vision was noted,and no recurrence was observed.
Conclusions
Cholesterol granulomas can present as superiotemporal or temporal orbital lesions. The diagnosis can be established based on CT and MRI. Most of patients can have no history of orbital trauma.
Assessment of Maternal and Child Health Care Services Performance in The Context of COVID-19 Pandemic in Addis Ababa, Ethiopia: Evidence From Routine Service Data
Authors: Gebreegziabher Senedu Bekele , Marrye Solomon Sisay , Kumssa Tsegaye Hailu , Merga Kassa Haile , Feleke Alemu Kibret , Dare Degu Jerene , Hallström Inger Kristensson , Yimer Solomon Abebe , Shargie Mulatu Biru 
Published: November 2021

Abstract
Background
In many settings, health care service provision has been modified to managing COVID-19 cases, and this has been affecting the provision of maternal and child health services. The aim of this study was to assess trends in selected maternal and child health services performance in the context of COVID-19 pandemic.
Methods
A cross-sectional data review was conducted in Addis Ababa, Ethiopia from April to May 2021. Routine health management information system database was reviewed from Addis Ababa Health Bureau for the period from July 2019 to March 2021 across all quarters. Proportions and mean with standard deviations were computed. T-test was used to assess statistically significant differences in services mean performance.
Results
PNC visit, new contraceptives accepters, safe abortion care and number of under-five years old children treated for pneumonia significantly decreased by 9.3% (p-value 0.04), 20.3% (p-value 0.004), 23.7% (p-value 0.01) and 77.2% (P-value < 0.001), respectively during the first eight months of the COVID-19 pandemic compared to the previous eight months’ average performance. The trends in ANC first visit, new contraceptive accepters, pentavalent-3 vaccination and under-five children treated for pneumonia began to decline between January-March 2020 when the COVID-19 pandemic began; with accelerated declines between April-June 2020 following national lockdown. The trends for the stated services began to increase during July-September 2020, during the last quarter of national lockdown. Contraceptive accepters and pentavalent-1 vaccination continued to decline and showed no recovery until January-March 2021when this study was completed.
Conclusions
Most of the maternal and child health services performance declined following the onset of COVID-19 pandemic and national lockdown, and most of the services began recovering during July-September 2020, the last quarter of national lockdown. However, new and repeat contraceptive accepters and pentavalent-1 recipients continue to decline and show no recovery during end of the study period. Implementing COVID-19 prevention measures and assuring the community about the safety of service delivery is imperative to ensure continuity of the maternal and child health services. Regular monitoring and evaluation of services performance is required to identify slowly recovering services and respond to potentially volatile changes during the COVID-19 pandemic.
ACRnet: Adaptive Cross-transfer Residual neural network for chest X-ray images discrimination
Authors: Zhang Wenyu 
Published: November 2021

Abstract
Background: Cardiothoracic diseases are a serious threat to human health and chest X-ray images have great reference value for the diagnosis and treatment. However, it is difficult for professional doctors to accurately diagnose cardiothoracic diseases through chest X-ray images sometimes and there will be different understanding based on human subjective differences, which will affect the judgment and treatment of diseases. Therefore, it is very necessary to develop a high-precision neural network to recognize chest X-ray images of cardiothoracic diseases.Methods: In this work, we cross-transfer the information extracted by the residual block and by the adaptive structure to different levels, which avoids the reduction of the adaptive function by residual structure and improves the recognition performance of the model. To evaluate the recognition ability of ACRnet, VGG16, InceptionV2, ResNet101 and CliqueNet are used for comparison. In addition, we use the deep convolution generative adversarial network (DCGAN) to expand the original dataset.Result: We find ACRnet has better recognition ability than other networks in identifying cardiomegaly, emphysema and normal. Besides, ACRnet's recognition ability has been greatly improved after data expansion. Conclusions: The experimental result indicates that emphysema and cardiomegaly can be effectively identified by ACRnet. Using DCGAN technology to expand the dataset can further improve the recognition ability of the model.
Clinical Characteristics and Allergen Detection of Perioperative Anaphylaxis: A 12-year Retrospective Analysis from an Anesthesia Clinic in China
Authors: Liu Xiaowen , Gong Ruisong , Xin Xin , Zhao Jing 
Published: November 2021

Abstract
Background: Anaphylaxis during anesthesia is a rare but often a potentially life-threatening event for patients. Identifying culprit agents responsible for anaphylaxis is of great important for avoiding potential re-exposure to allergens, but it poses great challenge for anesthetists. This retrospective study aimed to analyze the culprits of patients with a history of perioperative anaphylaxis referred to an anesthesia allergy clinic in China, and to evaluate the role of allergy diagnostic tests in clinical practice.Methods: A total of 145 patients (102 female/43 male) who attended the Anesthesia Allergy Clinic for allergen detection between 1 January 2009 and 31 December 2020 were reviewed retrospectively. Clinical characteristics, results of allergy diagnostic tests including skin and/or basophil activation tests, and the incidence of repeat anaphylaxis after use of recommended alternative anesthetics were obtained.Results: Of these 145 patients, 109 patients (75.2%, 74 females/35 males) were determined to experience perioperative anaphylaxis. The commonest presenting clinical feature was cardiovascular manifestations (n=63, 57.8%). According to diagnostic work up, the commonest culprits for perioperative anaphylaxis were neuromuscular blocking agents (n= 35, 32.1%). After diagnostic work up, 52 patients underwent repeat anesthesia, and none had recurrent anaphylaxis.Conclusions: This study suggests that neuromuscular blocking agents are the main culprits for perioperative anaphylaxis. For patients with perioperative anaphylaxis, allergy diagnostic tests are essential to identify causative agents, and to find suitable alternative drugs for the planning of repeat anesthesia.
Computational Analysis of Cortical Neuronal Excitotoxicity in a Large Animal Model of Neonatal Brain Injury
Authors: Kratimenos Panagiotis , Vij Abhya , Vidva Robinson , Koutroulis Ioannis , Delivoria-Papadopoulos Maria , Gallo Vittorio , Sathyanesan Aaron 
Published: November 2021

Abstract
Background: Neonatal hypoxic brain injury is a major cause of intellectual and developmental disability. Hypoxia causes neuronal dysfunction and death in the developing cerebral cortex due to excitotoxic Ca2+-influx. In the translational piglet model of hypoxic encephalopathy, we have previously shown that hypoxia overactivates Ca2+/Calmodulin (CaM) signaling via Sarcoma (Src) kinase in cortical neurons, resulting in overexpression of proapoptotic genes. However, identifying the exact relationship between alterations in neuronal Ca2+-influx, molecular determinants of cell death, and the degree of hypoxia in a dynamic system represents a significant challenge. Methods: We used experimental and computational methods to identify molecular events critical to the onset of excitotoxicity-induced apoptosis in the cerebral cortex of newborn piglets. We used 2-3 day-old piglets (normoxic [Nx], hypoxic [Hx], and hypoxic + Src-inhibitor-treatment [Hx+PP2]groups) for biochemical analysis of ATP production, Ca2+-influx, and Ca2+/CaM-dependent protein kinase kinase 2(CaMKK2) expression. We then used SimBiology to build a computational model of the Ca2+/CaM-Src-kinase signaling cascade, simulating Nx, Hx, and Hx+PP2 conditions. To evaluate our model, we used Sobol variance decomposition, multiparametric global sensitivity analysis, and parameter scanning.Results: Our model captures important molecular trends caused by hypoxia in the piglet brain. Incorporating the action of Src kinase inhibitor PP2 further validated our model and enabled predictive analysis of the effect of hypoxia on CaMKK2. We determined the impact of a feedback loop related to Src phosphorylation of NMDA receptors and activation kinetics of CaMKII. We also identified distinct modes of signaling wherein Ca2+ level alterations following Src kinase inhibition may not be a linear predictor of changes in Bax expression. Importantly, our model indicates that while pharmacological pre-treatment significantly reduces the onset of abnormal Ca2+-influx, there exists a window of intervention after hypoxia during which targeted modulation of Src-NMDAR interaction kinetics in combination with PP2 administration can reduce Ca2+-influx and Bax expression to similar levels as pre-treatment. Conclusions: Our model identifies new dynamics of critical components in the Ca2+/CaM-Src signaling pathway leading to neuronal injury and provides an essential framework for drug efficacy studies in translational models of neonatal brain injury for the prevention of intellectual and developmental disabilities.
Diabetes is not associated with greater pain and worse patient-reported outcome measures one year after laminoplasty for cervical spondylotic myelopathy
Authors: Nagata Kosei , Miyahara Junya , Nakamoto Hideki , Kawamura Naohiro , Takeshita Yujiro , Higashikawa Akiro , Ono Takashi , Fukushima Masayoshi , Okazaki Rentaro , Hara Nobuhiro , Kato So , Doi Toru , Taniguchi Yuki , Matsubayashi Yoshitaka , Tanaka Sakae , Oshima Yasushi 
Published: November 2021

Abstract
Although patients with diabetes reportedly have more peripheral neuropathy, the impacts of diabetes on postoperative recovery in pain and patient-reported outcome measures (PROMs) after laminoplasty for cervical spondylotic myelopathy (CSM) is not well characterized. The authors aimed to elucidate the effects of diabetes on neck/arm/hand/leg/foot pain and PROMs after laminoplasty CSM. The authors retrospectively reviewed 339 patients (82 with diabetes and 257 without) who underwent laminoplasty between C3 and C7 in 11 hospitals during April 2017−October 2019. Preoperative Numerical Rating Scale (NRS) scores in all five areas, the Short Form-12 Mental Component Summary, Euro quality of life 5-dimension, Neck Disability Index, and the Core Outcome Measures Index-Neck) were comparable between the groups. The between-group differences were also not significant in NRS scores and PROMs one after surgery. The change score of NRS hand pain was larger in the diabetic group than the nondiabetic group. The diabetic group showed worse preoperative score but greater improvement in the Short Form-12 Physical Component Summary than the nondiabetic group, following comparable score one year after surgery. These data indicated that the preoperative presence of diabetes, at least, did not adversely affect pain or PROMs one year after laminoplasty for CSM.
Platelet-activating Factor Acetyl Hydrolase IB2 Dysregulated Cell Proliferation in Ovarian Cancer
Authors: he yingying , he zhicheng , Zhang Xiaoyu , LIU SHUBAI 
Published: November 2021

Abstract
BackgroundOvarian cancer is the world’s largest cause of death for gynaecologic diseases. Platelet-activating factor acetyl hydrolase IB2 (PAF-AH IB2) is an intracellular serine esterase that hydrolyzes platelet-activating factor, a G-protein-like trimer with two catalytic subunits and one regulatory subunit. The deregulatory role of PAF-AHIB2 in the etiology of ovarian cancer is poorly understood. MethodsIn this study, the TCGA exploration and cancer tissue immunohistochemistry were utilized to investigate aberrant overexpression of PAF-AH IB2 in ovarian cancer. PAF-AH IB2 Stable knocking down (KD) ovarian cancer cells were established to investigate the impact on the cell proliferation, migration, and tumorigenicity in vitro. The whole transcription profiling, tyrosine kinase profiling and standard cell functional assays were integrated to explore the biological importance and mechanism of PAF-AH IB2 modulated in ovarian cancer. ResultsInteresting, PAF-AH IB2 was identified significantly overexpression in four subtypes of ovarian cancer. PAF-AHIB2 KD significantly reduced cancer cell proliferation, migration, and tumorigenicity in vitro, activated Caspases and caused cell cycle arrest, and making the cells more sensitive to PAF. Several key regulators of multiple tyrosine kinases-mediated signaling pathway were down-regulated in PAF-AH 1B2 KD cells, revealing a novel interaction network between the growth factor receptors pathway and PAF-AH 1B2 mediated PAF signalling.Conclusions These results discovered an unrevealed role for PAFAH IB2 as a novel potential therapy target and essential signaling mediators in ovarian cancer pathogenesis, as well as new potential preventive and therapeutic strategies to inhibit this enzyme in clinical treatment for ovarian cancer.