bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor visualization and fluorescence angiography with indocyanine green (ICG) in laparoscopic and robotic hepatobiliary surgery – valuation of early adopters from Germany
Authors: Franz Mareike , Arend Jörg , Wolff Stefanie , Perrakis Aristotelis , Rahimli Mirhasan , Negrini Victor-Radu , Stockheim Jessica , Lorenz Eric , Croner Roland 
Published: April 2021

Abstract

Objectives
Indocyanine green (ICG) is a fluorescent dye which was initially used for liver functional assessment. Moreover, it is of value for intraoperative visualization of liver segments and bile ducts or primary and secondary liver tumors. Especially in minimally invasive liver surgery, this is essential to enhance the precision of anatomical guided surgery and oncological quality. As early adopters of ICG implementation into laparoscopic and robotic-assisted liver surgery in Germany, we summarize the current recommendations and share our experiences.

Methods
Actual strategies for ICG application in minimally invasive liver surgery were evaluated and summarized during a review of the literature. Experiences in patients who underwent laparoscopic or robotic-assisted liver surgery with intraoperative ICG staining between 2018 and 2020 from the Magdeburg registry for minimally invasive liver surgery (MD-MILS) were evaluated and the data were analyzed retrospectively.

Results
ICG can be used to identify anatomical liver segments by fluorescence angiography via direct or indirect tissue staining. Fluorescence cholangiography visualizes the intra- and extrahepatic bile ducts. Primary and secondary liver tumors can be identified with a sensitivity of 69–100%. For this 0.5 mg/kg body weight ICG must be applicated intravenously 2–14 days prior to surgery. Within the MD-MILS we identified 18 patients which received ICG for intraoperative tumor staining of hepatocellular carcinoma (HCC), cholangiocarcinoma, peritoneal HCC metastases, adenoma, or colorectal liver metastases. The sensitivity for tumor staining was 100%. In 27.8% additional liver tumors were identified by ICG fluorescence. In 39% a false positive signal could be detected. This occurred mainly in cirrhotic livers.

Conclusions
ICG staining is a simple and useful tool to assess individual hepatic anatomy or to detect tumors during minimally invasive liver surgery. It may enhance surgical precision and improve oncological quality. False-positive detection rates of liver tumors can be reduced by respecting the tumor entity and liver functional impairments.
Paradoxical sleep deprivation induces oxidative stress in the submandibular glands of Wistar rats
Authors: Lasisi Taye J. , Shittu Shehu-Tijani T. , Abeje Jude I. , Ogunremi Kehinde J. , Shittu Seyyid A. 
Published: April 2021

Abstract

Objectives
Paradoxical sleep deprivation has been associated with impaired salivary secretion in rats. However, the mechanism that underlies this is not known. Therefore, this study assessed salivary and serum oxidative stress levels following paradoxical sleep deprivation in rats.

Methods
Twenty-one male Wistar rats randomly divided into three groups of seven rats each as; Control (C); partial sleep-deprived (PSD); and total sleep-deprived (TSD) were used. Malondialdehyde (MDA) concentration, Superoxide dismutase (SOD), and catalase activities were evaluated in saliva, serum, and submandibular glands after seven days of sleep deprivation. Data were expressed as mean ± standard error of the mean and analyzed using one-way ANOVA, Tukey HSD post hoc, and Pearson’s correlation tests.

Results
Serum MDA levels were significantly higher in both the TSD and PSD groups compared to the control group whereas only the TSD group showed higher submandibular MDA levels compared to the PSD group and the control group. Submandibular SOD activity was significantly lower in both the TSD and PSD groups compared to the control group. Serum catalase activity was significantly lower in the TSD group only compared to the control group.

Conclusions
These results have demonstrated for the first time that paradoxical sleep deprivation was associated with changes in the oxidant/antioxidant defense system in the submandibular salivary glands of male Wistar rats which may contribute to impairment in salivary secretion.
A case of statin-induced liver injury with positive rechallenge with a second statin. Is there a class effect?
Authors: Onfiani Giovanna , Nascimbeni Fabio , Carubbi Francesca 
Published: April 2021

Abstract

Objectives
Statins have proved to reduce cardiovascular morbidity and mortality in high-risk population and are generally well tolerated, although adverse events can occur. Up to 3% of patients develop aminotransferases elevation, which usually normalizes with continued treatment and hardly is associated with clinical symptoms. Serious statin-related liver injury is exceedingly rare. Furthermore, literature regarding rechallenge with a second statin is extremely poor. Some authors caution that re-exposure to these drugs is associated with a more serious liver injury but safe switching to a second statin after drug-induced liver injury (DILI) is also reported.

Case presentation
We describe a case of a middle-aged woman who developed hepatocellular liver injury after simvastatin dose escalation; a rechallenge with low dose rosuvastatin caused rapid recurrence of DILI.

Conclusions
In our opinion, clinicians should be very cautious upon rechallenge and closely follow-up patients who experienced statin-induced liver injury when trying re-exposure to another statin.
The effects of pre-pregnancy obesity and gestational weight gain on maternal lipid profiles, fatty acids and insulin resistance
Authors: Gulecoglu Onem Muge Gul , Coker Canan , Baysal Kemal , Altunyurt Sabahattin , Keskinoglu Pembe 
Published: April 2021

Abstract

Objectives
Pregnancy is associated with physiological alterations in insulin sensitivity and lipid metabolism. This study investigates the associations between pregestational body mass index (pBMI) and the rate of gestational weight gain (rGWG) in the second trimester with the biomarkers of lipid, fatty acids metabolism and insulin resistance.

Methods
Sixty nine pregnant women followed. The body weights of the pregnant women were measured and blood samples were obtained at 11–14th and 24–28th weeks of pregnancy. Glucose, total cholesterol, triglyceride, HDL cholesterol, LDL cholesterol, insulin levels and fatty acids were measured. Rate of GWG (kg/week) and The Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) were calculated. The pregnant women were stratified according to their pBMI and the 2nd trimester rGWG.

Results
The rate of GWG was significantly higher for the group with pBMI<25, compared to the group with pBMI≥25 (p=0.024). Triglyceride, total cholesterol, LDL and HDL cholesterol were significantly increased in the second trimester compared with the first trimester. Palmitic acid, oleic acid, linoleic acid, myristic acid, docosahexaenoic acid (DHA), arachidonic acid (AA), total omega-6 (n − 6) and omega-3 (n − 3) fatty acid levels and n − 6/n − 3 ratio were significantly higher in the second trimester. Glucose was significantly decreased and insulin was increased in the second trimester. In the overweight/obese group; HOMA-IR, insulin, AA, palmitoleic acid and stearic acid were found to be high in comparison to the group with low/normal pBMI. No parameters were associated with rGWG.

Conclusions
The changes in lipid parameters, free fatty acids, insulin and HOMA-IR in the second trimester were compatible with the changes in lipid metabolism and the development of insulin resistance. Pregestational BMI was shown to have a stronger influence on lipid profile, insulin resistance, and fatty acids than rGWG.
Four long noncoding RNAs act as biomarkers in lung adenocarcinoma
Authors: Zhang Zhihui , Yang Liu , Li Yujiang , Wu Yunfei , Li Xiang , Wu Xu 
Published: April 2021

Abstract

Introduction
Lung adenocarcinoma (LUAD) is currently one of the most common malignant tumors worldwide. However, there is a lack of long noncoding RNA (lncRNA)-based effective markers for predicting the prognosis of LUAD patients. We identified four lncRNAs that can effectively predict the prognosis of LUAD patients.

Methods
We used data gene expression profile for 446 patients from The Cancer Genome Atlas database. The patients were randomly divided into a training set and a test set. Significant lncRNAs were identified by univariate regression. Then, multivariate regression was used to identify lncRNAs significantly associated with the survival rate. We constructed four-lncRNA risk formulas for LUAD patients and divided patients into high-risk and low-risk groups. Identified lncRNAs subsequently verified in the test set, and the clinical independence of the lncRNA model was evaluated by stratified analysis. Then mutated genes were identified in the high-risk and low-risk groups. Enrichment analysis was used to determine the relationships between lncRNAs and co-expressed genes. Finally, the accuracy of the model was verified using external database.

Results
A four-lncRNA signature (AC018629.1, AC122134.1, AC119424.1, and AL138789.1) has been verified in the training and test sets to be significantly associated with the overall survival of LUAD patients.

Conclusions
The present study demonstrated that identified four-lncRNA signature can be used as an independent prognostic biomarker for the prediction of survival of LUAD patients.
Use of microspheres in embolization for unruptured renal angiomyolipomas
Authors: Shimohira Masashi , Nagai Keiichi , Ohta Kengo , Sawada Yusuke , Naiki Taku , Nagai Takashi , Yasui Takahiro , Shibamoto Yuta 
Published: April 2021

Abstract

Purpose
To describe our initial experience with use of microspheres in transcatheter arterial embolization (TAE) for unruptured sporadic renal angiomyolipomas (AMLs).

Materials and methods
Seven consecutive patients with seven unruptured sporadic renal AMLs, 6 females and 1 male, with a median age of 45 years (range, 30–69 years), underwent TAE using microspheres between November 2016 and February 2020. We evaluated the technical success rate, complications related to the procedure, clinical success rate, and the shrinkage rate of renal AML. Technical success was defined as the completion of TAE. Clinical success was defined as presence of shrinkage of the renal AML after TAE.

Results
In all patients, TAE using microspheres was accomplished and technical success rate was 100% (7/7). Three patients exhibited slight pain, but it improved with only observation, and the minor complication rate was 43% (3/7) and major complication rate was 0% (0/7). After the TAE, shrinkage of renal AML was confirmed in 6 of 7 patients, and clinical success rate was 86% (6/7). The median of shrinkage rate was 47% (range, 26–83%) with a median follow-up period of 19 months (range, 4–30 months).

Conclusion
TAE using microspheres appears to be effective and safe for unruptured sporadic renal AMLs.
The crystal structure of ethyl 5-methyl-7-(4-(phenylthio)phenyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate, C20H19N5O2S
Authors: Wang Wenxiang 
Published: April 2021

Abstract
C20H19N5O2S, monoclinic, C2/c (no. 15), a = 18.861(4) Å, b = 12.000(2) Å, c = 17.787(4) Å, β = 105.15(3)°, V = 3885.7(15) Å3, Z = 8, R

gt
(F) = 0.0654, wR

ref
(F
2) = 0.1538, T = 293(2) K.
Improvement of long-term cycling performance of high-nickel cathode materials by ZnO coating
Authors: Wang Fangfang , Hong Ruoyu , Lu Xuesong , Liu Huiyong , Zhu Yuan , Zheng Ying , Hui David 
Published: April 2021

Abstract
The high-nickel cathode material of LiNi0.8Co0.15Al0.05O2 (LNCA) has a prospective application for lithium-ion batteries due to the high capacity and low cost. However, the side reaction between the electrolyte and the electrode seriously affects the cycling stability of lithium-ion batteries. In this work, Ni2+ preoxidation and the optimization of calcination temperature were carried out to reduce the cation mixing of LNCA, and solid-phase Al-doping improved the uniformity of element distribution and the orderliness of the layered structure. In addition, the surface of LNCA was homogeneously modified with ZnO coating by a facile wet-chemical route. Compared to the pristine LNCA, the optimized ZnO-coated LNCA showed excellent electrochemical performance with the first discharge-specific capacity of 187.5 mA h g−1, and the capacity retention of 91.3% at 0.2C after 100 cycles. The experiment demonstrated that the improved electrochemical performance of ZnO-coated LNCA is assigned to the surface coating of ZnO which protects LNCA from being corroded by the electrolyte during cycling.
Teachers and supervisors negotiating face during critical account requests in post observation feedback
Authors: Donaghue Helen 
Published: April 2021

Abstract
This article shows, through the analysis of “real life” institutional interaction, how experienced teachers and supervisors negotiate face when teachers contest or manage supervisors’ critical account requests during post observation feedback meetings. A linguistic micro-analysis of data extracts is supplemented with ethnographic data drawn from participant perspective interviews and researcher knowledge. The analysis shows how participants subtly and skillfully employ facework to manage the potential face-threat engendered by criticism and disagreement. This facework is mostly successful, but in one case the supervisor orients to face-threat and closes down the topic of discussion. This demonstrates that face is consequential to both unfolding talk and the feedback goal of dialogue and development. Feedback participants, both supervisors and teachers, also engage in moves of face support and face maintenance. The analysis shows face to be an emergent, situated relationship, co-constructed by both participants, and also shows that participants are willing to risk face-threat to achieve institutional goals (supervisors) and defend their actions (teachers). This supports the view that face-threat is rational and common and indicates that criticism, account requests, and disagreements are acceptable norms in post observation feedback.
Motzen und Moral
Authors: Thielemann Nadine , Göke Regina , Savych Zlatoslava 
Published: April 2021

SummaryThe paper analyses complaining behaviour at the workplace across several languages (French, German in Austria and in Germany, Polish and Russian). As speech acts, complaints deal with socially unacceptable actions that are brought up as problematic issues retrospectively. This may include critical evaluative assessment or the request for compensation. Data have been collected using an online discourse completion task (DCT) including discourse scenarios in which the power distance between the participants as well as the weight of the transgression/misconduct varied. The results show that complaining strategies vary along several dimensions (e. g. mention of transgression +/-, justification of complaint +/-, way in which a solution or compensation is requested). The observed differences in complaining strategies can be interpreted in terms of culture-specific ways in which the relationship at the workplace is conceived of. Despite the general restrictions of DCT as a method of data collection, we suggest utilizing data and results derived from their analysis in the context of courses of intercultural business communication and of business language courses.
On the argument structure of complex denominal verbs in Latin: a syntactic approach
Authors: Mateu Jaume 
Published: April 2021

AbstractIn this paper I offer a syntactic approach to the formation of complex denominal verbs in Latin. Two basic types of prefixed locative denominal verbs can be distinguished in this language: location ones “agglutinate” a PP expressing location, whereas locatum ones contain a noun expressing thelocatumobject. Assuming a syntactic distinction between Incorporation and Conflation in denominal verb formation, I claim that prefixed location verbs are formed viaIncorporation(i.e. Internal Merge), whereas prefixed locatum verbs are formed viaConflation(i.e. External Merge). Unprefixed locative verbs can only be interpreted as locatum predicates, but unlike prefixed locatum verbs, they are analyzed as involving a possessive relation and as being formed via incorporation. The present approach also provides an explanation of why Romance locatum verbs, unlike location ones, are not necessarily prefixed. It is also claimed that unprefixedandprefixed locatum verbs in Romance are formed via incorporation rather than via conflation, its reason being related to the typological shift from the presence of a typical conflation pattern in satellite-framed Latin to a lack of it in verb-framed Romance languages. Finally, I show that Latin prefixed denominal verbs and prefixed deadjectival ones are all telic and project a ResultP in syntax. In contrast, this projection can be argued to be absent from unprefixed denominal and deadjectival verbs.
On-Machine Measurements im Internet of Production
Authors: Sanders Mark , Xi Tiandong , Dahlem Philipp , Fey Marcel , Schmitt Robert H. , Brecher Christian 
Published: April 2021

Abstract
Bei On-Machine Measurements werden Bauteile direkt mit dem Messtastersystem der Maschine gemessen. So wird im Vergleich zur Messung per KMG (Koordinatenmessgeräte) der Aufwand zur dimensionellen Bauteilprüfung und einer anschließenden Korrektur fehlerhafter Bauteile erheblich reduziert. Es wird eine Dateninfrastruktur vorgestellt, welche die aus der Maschine stammenden Daten annotiert speichert. Mithilfe der gesammelten Daten kann die Maßhaltigkeit des Bauteils automatisch erkannt werden.**
Herausforderungen bei der Einführung neuer digitaler Technologien bei KMU Teil 1: Am Beispiel der Künstlichen Intelligenz
Authors: Axmann Bernhard , Harmoko Harmoko 
Published: April 2021

Abstract
Diese Veröffentlichung ist der erste von zwei Teilen der KI-Studie für KMU, in der der langsame Fortschritt der Digitalisierung in deutschen KMU und die damit verbundenen Herausforderungen aufgezeigt werden. Demgegenüber stehen die großen Vorteile der Digitalisierung mit Künstlicher Intelligenz. Die geringen Aktivitäten beruhen auf der Skepsis, dass KI nicht für KMU geeignet ist. Die begrenzten Ressourcen der KMU sowie die Herausforderungen in Bezug auf Daten und ihre Infrastruktur müssen durch den Aufbau von Vertrauen und Fähigkeiten der KMU und die Bereitstellung von Bewertungswerkzeugen sowie Richtlinien für KI-Anwendungen überwunden werden.**
Only the Fastest Corticospinal Fibers Contribute to β Corticomuscular Coherence
Authors: Ibáñez J. , Del Vecchio A. , Rothwell J. C. , Baker S. N. , Farina D. 
Published: April 2021

Human corticospinal transmission is commonly studied using brain stimulation. However, this approach is biased to activity in the fastest conducting axons. It is unclear whether conclusions obtained in this context are representative of volitional activity in mild-to-moderate contractions. An alternative to overcome this limitation may be to study the corticospinal transmission of endogenously generated brain activity. Here, we investigate in humans (N= 19; of either sex), the transmission speeds of cortical β rhythms (∼20 Hz) traveling to arm (first dorsal interosseous) and leg (tibialis anterior; TA) muscles during tonic mild contractions. For this purpose, we propose two improvements for the estimation of corticomuscular β transmission delays. First, we show that the cumulant density (cross-covariance) is more accurate than the commonly-used directed coherence to estimate transmission delays in bidirectional systems transmitting band-limited signals. Second, we show that when spiking motor unit activity is used instead of interference electromyography, corticomuscular transmission delay estimates are unaffected by the shapes of the motor unit action potentials (MUAPs). Applying these improvements, we show that descending corticomuscular β transmission is only 1–2 ms slower than expected from the fastest corticospinal pathways. In the last part of our work, we show results from simulations using estimated distributions of the conduction velocities for descending axons projecting to lower motoneurons (from macaque histologic measurements) to suggest two scenarios that can explain fast corticomuscular transmission: either only the fastest corticospinal axons selectively transmit β activity, or else the entire pool does. The implications of these two scenarios for our understanding of corticomuscular interactions are discussed.SIGNIFICANCE STATEMENTWe present and validate an improved methodology to measure the delay in the transmission of cortical β activity to tonically-active muscles. The estimated corticomuscular β transmission delays obtained with this approach are remarkably similar to those expected from transmission in the fastest corticospinal axons. A simulation of β transmission along a pool of corticospinal axons using an estimated distribution of fiber diameters suggests two possible mechanisms by which fast corticomuscular transmission is achieved: either a very small fraction of the fastest descending axons transmits β activity to the muscles or, alternatively, the entire population does and natural cancellation of slow channels occurs because of the distribution of axon diameters in the corticospinal tract.
Comparative Efficacy of Bronchiolitis Interventions in Acute Care: A Network Meta-analysis
Authors: Elliott Sarah Alexandra , Gaudet Lindsay A. , Fernandes Ricardo M. , Vandermeer Ben , Freedman Stephen B. , Johnson David W. , Plint Amy C. , Klassen Terry P. , Allain Dominic , Hartling Lisa 
Published: April 2021

CONTEXT:Uncertainty exists as to which treatments are most effective for bronchiolitis, with considerable practice variation within and across health care sites.OBJECTIVE:A network meta-analysis to compare the effectiveness of common treatments for bronchiolitis in children aged ≤2 years.DATA SOURCES:Medline, Embase, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature, ClinicalTrials.gov, and the World Health Organization International Clinical Trials Registry Platform were searched from inception to September 1, 2019.STUDY SELECTION:A total 150 randomized controlled trials comparing a placebo or active comparator with any bronchodilator, glucocorticoid steroid, hypertonic saline solution, antibiotic, helium-oxygen therapy, or high-flow oxygen therapy were included.DATA EXTRACTION:Data were extracted by 1 reviewer and independently verified. Primary outcomes were admission rate on day 1 and by day 7 and hospital length of stay. Strength of evidence was assessed by using Confidence in Network Meta-Analysis .RESULTS:Nebulized epinephrine (odds ratio: 0.64, 95% confidence interval [CI]: 0.44 to 0.93, low confidence) and nebulized hypertonic saline plus salbutamol (odds ratio: 0.44, 95% CI: 0.23 to 0.84, low confidence) reduced the admission rate on day 1. No treatment significantly reduced the admission rate on day 7. Nebulized hypertonic saline (mean difference: −0.64 days, 95% CI: −1.01 to −0.26, low confidence) and nebulized hypertonic saline plus epinephrine (mean difference: −0.91 days, 95% CI: −1.14 to −0.40, low confidence) reduced hospital length of stay.LIMITATIONS:Because we did not report adverse events in this analysis, we cannot make inferences about the safety of these treatments.CONCLUSIONS:Although hypertonic saline alone, or combined with epinephrine, may reduce an infant’s stay in the hospital, poor strength of evidence necessitates additional rigorous trials.