bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prática docente no ensino superior e os saberes da formação inicial: constituindo a identidade profissional
Authors: Amaral Bruna Lucas de Melo , Pinto Cesar Augusto Sadalla , Nóbrega-Therrien Silvia Maria 
Published: December 2021

O trabalho aborda a relação entre formação inicial e prática docente no ensino superior, enfatizando os saberes docentes mobilizados pelos professores e suas influências para a constituição de sua identidade profissional. Nesse artigo, questionamos quais saberes e práticas da formação inicial refletem na atividade profissional docente de professores de Educação Física do ensino superior? E como esses saberes e práticas contribuem para construção de sua identidade profissional? Nesse sentido traçamos como objetivo analisar a relação entre a prática docente e a formação inicial de professores universitários, mapeando os principais saberes adquiridos durante o processo formativo dos sujeitos pesquisados e as contribuições desses saberes para a constituição de sua identidade profissional. Utilizamos de uma abordagem predominantemente qualitativa, partindo de um estudo de caso no âmbito do curso de Licenciatura em Educação Física de uma instituição pública de ensino superior do estado do Ceará, tendo como sujeitos da pesquisa, professores do referido curso. Como técnica de coleta de dados utilizamos a entrevista semiestruturada. A pesquisa nos revelou que os saberes da formação inicial se encontram refletidos nas atividades de ensino desenvolvidas pelos professores pesquisados, porém, não podemos considerá-los determinantes, tendo em vista, que os professores se encontram mobilizando outros saberes que não foram enfatizados em sua formação inicial. Contatamos ainda, a contribuição dessa etapa formativa inicial no processo de construção da identidade docente dos professores pesquisados, por meio de referências de ensino que marcaram de forma positiva (ou negativa) a formação desses sujeitos.
Programas de exercício físico no domicílio dos idosos frágeis: revisão integrativa
Authors: Faria Ana da Conceição Alves , Martins Maria Manuela Ferreira Pereira da Silva , Laredo-Aguilera José Alberto , Ribeiro Olga Maria Pimenta Lopes , Fonseca Luciano José Moreira 
Published: December 2021

Introdução: O exercício físico tem o potencial de melhorar a condição de saúde dos idosos frágeis. No entanto, o conhecimento sobre exercício físico em contexto domiciliário para esta população é escasso. Objetivo: Investigar na literatura científica programas de exercício físico implementados no domicílio dos idosos frágeis com contribuições para a capacidade funcional. Métodos: Revisão integrativa da literatura entre 2010 e 2020, nas bases de dados Web of Science, Medline e Cinahl. Resultados: De 290 artigos, incluímos 12 artigos que revelaram efeitos positivos dos programas de exercício físico no domicílio na capacidade funcional dos idosos frágeis. Os programas de exercício físico incluíram treino de força, equilíbrio, flexibilidade e resistência. Conclusão: Esta revisão demonstra os benefícios do exercício físico no domicílio dos idosos frágeis, não só na capacidade funcional, assim como na participação das atividades da vida diária, incidência de quedas, medo de cair, intensidade da dor, episódios de doença aguda e qualidade de vida.
Nursing diagnoses in hospitalized patients with COVID-19 in Indonesia
Authors: Hidayati Nur , Hadi Farhan , Suratmi Suratmi , Maghfiroh Isni Lailatul , Andarini Esti , Setiawan Henri , Lutfi Sandi Yudisa Diaz 
Published: December 2021

Background: The COVID-19 pandemic has become a global public health issue, and the roles of nurses are very much needed in providing nursing services in the current situation. The enforcement of appropriate nursing diagnoses for patients with COVID-19 is also fundamental in determining proper nursing care to help the patients achieve maximum health.
Objective: This study aimed to describe and analyze nursing diagnoses in patients with COVID-19 treated in the isolation rooms and ICUs.
Methods: This study used a secondary data analysis from hospital medical record data of patients with COVID-19 from early December 2020 to the end of February 2021. Data were selected using a cluster random sampling technique and analyzed using descriptive statistics.
Results: The results showed that the signs and symptoms of the patients with COVID-19 that often appeared were fever, cough, shortness of breath, and decreased consciousness. The common nursing diagnoses in the hospitalized patients with COVID-19 were hyperthermia, ineffective airway clearance, gas exchange disorder, self-care deficit, spontaneous ventilation disorder, spontaneous circulation disorder, knowledge deficit, and shock risk.
Conclusion: This study offers an insight into nursing practices in the hospital setting, which can be used as a basis for nurses to perform complete nursing assessments and nursing diagnoses during the pandemic.
POTENTIAL USE OF 'ENSET' FIBER ASH AS PARTIAL REPLACEMENT OF CONVENTIONAL FILLER MATERIAL IN HOT MIX ASPHALT
Authors: Kibru Yisak , Geremew Anteneh , Yigezu Biruk 
Published: December 2021

The main problems in road construction and maintance work in Ethiopia availability of a large amount of appropriate quality materials in road construction sites, aggregates in different size fractions are not readily obtainable, necessitating their procurement from long distances, thereby causing an exorbitant increase in construction costs. One of the main problems in constructing the asphalt paving mixture is obtaining a sufficient amount of filler material from crushing fine rock material and low percent using ordinary Portland cement (OPC), hydrated lime (HL) and marble dust. To overcome this problem, it is important to come across alternative filler material to address this gap using naturally available material. Currently, renewed attention has been given to the use of ‘waste’ materials instead of conventional aggregates in pavement construction. This research study investigates the potential use of ‘Enset’ fiber ash as a partial replacement of conventional filler material in hot mix asphalt supported by experimental laboratory investigation. In order to achieve this study, purposive sampling techniques were adopted to select the sample size and location. The study evaluated the potential of ‘Enset’ fiber ash as filler for the design of dense-graded hot mix asphalt by referencing traditional filler control mix procedures based on standard specifications, and a crush rock filler was utilized as a conventional filler material as a control for comparison. The Marshal Stability and Rutting Test (RT) was conducted to determine the HMA specimen's performance. Several HMA specimens were prepared using aggregate blend according to ASTM D 1559 with four different percentages of ‘Enset’ fiber ash (EFA) of 15%, 25%, 35% and 45% filler replacement the total filler weight used in the control mix. Specimens were prepared and tests performed according to EN 12697-22 procedure-B for rutting test. All HMA properties were taken at 4% air void and determined their optimum bitumen content (OBC). Almost the same result with the control mix was observed in the study at 15% and 25% of the ‘Enset’ fiber ash (EFA) replacement. However, higher Marshall Stability, a lower void filled with asphalt, better flow, a good void in mineral were observed at 25% ‘Enset’ fiber ash (EFA) replacement. At this rate, the rutting performance is less than that of the control mix but is within the specifications of 2.78mm and 2.9 mm of rutting depth less than 6mm that satisfies the EN 13108 requirement. As a result, Enset fiber ash filler can replace traditional filler material up to 25% of the total filler weight used in this study. It was recommended to use ‘Enset' fiber ash (EFA) as a filler material as a partial replacement in a bituminous paving mixture up to the specificed percentage by weight replacement.
Highly Sensitive Whole-Cell Biosensor for Cadmium Detection Based on a Negative Feedback Circuit
Authors: Zhang Guangbao , Hu Shuting , Jia Xiaoqiang 
Published: December 2021

Although many whole-cell biosensors (WCBs) for the detection of Cd2+ have been developed over the years, most lack sensitivity and specificity. In this paper, we developed a Cd2+ WCB with a negative feedback amplifier in P. putida KT2440. Based on the slope of the linear detection curve as a measure of sensitivity, WCB with negative feedback amplifier greatly increased the output signal of the reporter mCherry, resulting in 33% greater sensitivity than in an equivalent WCB without the negative feedback circuit. Moreover, WCB with negative feedback amplifier exhibited increased Cd2+ tolerance and a lower detection limit of 0.1 nM, a remarkable 400-fold improvement compared to the WCB without the negative feedback circuit, which is significantly below the World Health Organization standard of 27 nM (0.003 mg/L) for cadmium in drinking water. Due to the superior amplification of the output signal, WCB with negative feedback amplifier can provide a detectable signal in a much shorter time, and a fast response is highly preferable for real field applications. In addition, the WCB with negative feedback amplifier showed an unusually high specificity for Cd2+ compared to other metal ions, giving signals with other metals that were between 17.6 and 41.4 times weaker than with Cd2+. In summary, the negative feedback amplifier WCB designed in this work meets the requirements of Cd2+ detection with very high sensitivity and specificity, which also demonstrates that genetic negative feedback amplifiers are excellent tools for improving the performance of WCBs.
Absence of Obesity Paradox in All-Cause Mortality Among Chinese Patients With an Implantable Cardioverter Defibrillator: A Multicenter Cohort Study
Authors: Zhou Bin , Sun Xuerong , Yu Na , Zhao Shuang , Chen Keping , Hua Wei , Su Yangang , Yang Jiefu , Liang Zhaoguang , Xu Wei , Tang Min , Zhang Shu 
Published: December 2021

Background: The results of studies on the obesity paradox in all-cause mortality are inconsistent in patients equipped with an implantable cardioverter-defibrillator (ICD). There is a lack of relevant studies on Chinese populations with large sample size. This study aimed to investigate whether the obesity paradox in all-cause mortality is present among the Chinese population with an ICD.Methods: We conducted a retrospective analysis of multicenter data from the Study of Home Monitoring System Safety and Efficacy in Cardiac Implantable Electronic Device–implanted Patients (SUMMIT) registry in China. The outcome was all-cause mortality. The Kaplan–Meier curves, Cox proportional hazards models, and smooth curve fitting were used to investigate the association between body mass index (BMI) and all-cause mortality.Results: After inclusion and exclusion criteria, 970 patients with an ICD were enrolled. After a median follow-up of 5 years (interquartile, 4.1–6.0 years), in 213 (22.0%) patients occurred all-cause mortality. According to the Kaplan–Meier curves and multivariate Cox proportional hazards models, BMI had no significant impact on all-cause mortality, whether as a continuous variable or a categorical variable classified by various BMI categorization criteria. The fully adjusted smoothed curve fit showed a linear relationship between BMI and all-cause mortality (p-value of 0.14 for the non-linearity test), with the curve showing no statistically significant association between BMI and all-cause mortality [per 1 kg/m2 increase in BMI, hazard ratio (HR) 0.97, 95% CI 0.93–1.02, p = 0.2644].Conclusions: The obesity paradox in all-cause mortality was absent in the Chinese patients with an ICD. Prospective studies are needed to further explore this phenomenon.
Effect of Shenfu Injection on Reperfusion Injury in Patients Undergoing Primary Percutaneous Coronary Intervention for ST Segment Elevation Myocardial Infarction: A Pilot Randomized Clinical Trial
Authors: Wang Xiao , Miao Huangtai , Yan Yan , Guo Ruifeng , Gong Wei , He Yi , Wang Hui , Ma Xinliang , Nie Shaoping 
Published: December 2021

Background: Shenfu injection is a traditional Chinese medicine formulation that alleviates ischemia-reperfusion injury through multiple pharmacologic effects. However, no data are available regarding its efficacy in patients with myocardial infarction. We aimed to examine the effects of Shenfu injection on infarct size in patients with ST segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI).Methods: From April 2016 to February 2018, 40 patients with first-time anterior STEMI undergoing primary PCI within 6 h of symptom onset were randomized 1:1 to intravenous Shenfu injection (80 ml Shenfu injection + 70 ml 5% glucose injection) or placebo (150 ml 5% glucose injection) before reperfusion. Treatment started before PCI and maintained for 5 days after PCI. The primary end point was infarct size assessed by CK-MB area under the curve (AUC) over 72 h and cardiac magnetic resonance (CMR) imaging 4 ± 1 days after PCI.Results: Infarct size by area under the curve for CK-MB over 72 h did not differ between the Shenfu injection and placebo groups (5602.5 [3539.4–7526.4] vs. 6403.2 [2234.4–8340.6] ng·h/ml, P = 0.82). Among 32 patients who underwent CMR Imaging, a nominal reduction in infarct size was observed in the Shenfu injection group compared with the placebo group (23.9 [15.2–28.5] % vs. 27 [21.9–31.9] %, P = 0.42). After excluding patients with no or minimal infarct, there was a trend toward reduction in infarct size in the Shenfu injection group (24.1 [20.3–29.3] % vs. 29.1 [24.5–32] %, P = 0.18). Incidence of adverse events was similar between the groups.Conclusions: This pilot study showed that the use of Shenfu injection was safe but did not reduce infarct size by CMR Imaging and CK-MB release kinetics in reperfused patients with STEMI. Larger studies (confining to patients with extensive infarct size) to evaluate the efficacy of Shenfu injection on reperfusion injury are warranted.Clinical Trail Registration:clinicaltrials.gov, identifier: NCT02709798.
Growth Hormone Cotreatment for Low-Prognosis Patients According to the POSEIDON Criteria
Authors: Liu Xueying , Xu Jingxiao , Bi Lixin , Liu Peihao , Jiao Xue 
Published: December 2021

BackgroundPoor ovarian response (POR) remains one of the most challenging conditions in assisted reproduction technology. Previous studies seemed to indicate that growth hormone (GH) was a potential solution for the dilemma of POR; however, the role GH played on the low-prognosis patients diagnosed and stratified by the POSEIDON criteria remains indistinct.MethodsThis retrospective study was performed among women with POR according to the POSEIDON criteria who failed a previous in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycle, and the subsequent cycle was under GH cotreatment and conducted within 12 months. These participants were stratified into four groups according to the POSEIDON criteria. The comparison was implemented between the failed cycle and the cycle treated with GH. Generalized estimating equation (GEE) multivariate regression was applied for data analysis.ResultsA total of 428 low-prognosis women were included in this study. GH supplementation improved the live birth rates (47.66%, 28.33%, 45.45%, and 24.07%; in groups 1, 2, 3, and 4, respectively) and the clinical pregnancy rates (OR 19.16, 95% CI 7.87–46.63, p &lt; 0.001; OR 7.44, 95% CI 1.65–33.55, p = 0.009; OR 10.19, 95% CI 2.39–43.52, p = 0.002; OR 27.63, 95% CI 4.46–171.11, p &lt; 0.001; in groups 1, 2, 3, and 4, respectively) in all four POSEIDON groups. The number of oocytes retrieved was significantly elevated in the subgroups with normal ovarian reserve (IRR 1.47, 95% CI 1.36–1.59, p &lt; 0.001; IRR 1.31, 95% CI 1.15–1.49, p &lt; 0.001; in groups 1 and 2, respectively). The number of day-3 good-quality embryos was significantly elevated in the subgroups with either normal ovarian reserve or aged young (IRR 2.13, 95% CI 1.78–2.56, p &lt; 0.001; IRR 1.54, 95% CI 1.26–1.89, p &lt; 0.001; IRR 1.47, 95% CI 1.10–1.98, p = 0.010; in groups 1, 2, and 3, respectively).ConclusionGrowth hormone cotreatment could ameliorate the pregnancy outcome for women with POR under the POSEIDON criteria who failed a previous IVF/ICSI cycle. The application of growth hormone for low-prognosis women who experienced a failed cycle might be considered and further studied.
The Study of Optimization of Flocculation and Destabilization Technology of Waste PEM Drilling Fluid in Bohai Oilfield
Authors: Liu Yang , Zhang Yuchen , Xie Tao , Yue Ming , Wang Dongsen , Li Bin 
Published: December 2021

In light of the difficulty of solid-liquid separation of waste PEM drilling fluid in the Bohai oilfield, constructing an inorganic-organic flocculation system is proposed and the processing method of destabilization technology is optimized. The biggest influence factor on the flocculation process of PEM drilling fluid was determined by designing an orthogonal test. The flocculation mechanism was researched through single factor optimization, combined with zeta potential and particle size distribution test. The results showed that the most significant factors affecting the flocculation of waste PEM drilling fluid were the dosage of inorganic flocculant CaCl2 and flocculation pH value. When the dosage of inorganic flocculant CaCl2 was 1.2% (w/v), the dosage of organic flocculant SDYJ-2 was 0.05%, the flocculation pH value was 3, and the flocculation time was 5 min, the flocculation technology reached the optimization and then the liquid yield can reach 70.96%. The mechanism of flocculation and destabilization was as follows: the inorganic flocculant of CaCl2 mainly reduced the zeta potential of clay particles through electric neutralization. 1% CaCl2 could reduce the potential mean value of drilling fluid system from -38.1 mV to -32.5 mV, and then decrease the repulsion among suspensions. Through bridging curling and electric neutralization, the organic flocculant of SDYJ-2 can absorb and wrap the clay particles after flocculation destabilization to form a network spatial structure, which made clay particles aggregate into large flocs and particles. D50 can increase by 21.5 times, when the concentration of SDYJ-2 was 0.15%.
Spondyloocular Syndrome: A Novel XYLT2 Variant with Description of the Neonatal Phenotype
Authors: Doddato Gabriella , Fabbiani Alessandra , Fallerini Chiara , Bruttini Mirella , Hadjistilianou Theodora , Landi Martino , Coradeschi Caterina , Grosso Salvatore , Tomasini Barbara , Mencarelli Maria Antonietta , Renieri Alessandra , Ariani Francesca 
Published: December 2021

Spondyloocular syndrome (SOS) is a skeletal disorder caused by pathogenic variants in XYLT2 gene encoding a xylotransferase involved in the biosynthesis of proteoglycans. This condition, with autosomal recessive inheritance, has a high phenotypic variability. It is characterized by bone abnormalities (osteoporosis, fractures), eye and cardiac defects, hearing impairment, and varying degrees of developmental delay. Until now only 20 mutated individuals have been reported worldwide. Here, we describe two siblings from consanguineous healthy parents in which a novel homozygous frameshift variant c.1586dup p(Thr530Hisfs*) in the XYLT2 gene was detected by exome sequencing (ES). The first patient (9 years) presented short stature with skeletal defects, long face, hearing loss and cataract. The second patient, evaluated at a few days of life, showed macrosomia, diffuse hypertrichosis on the back, overabundant skin in the retronucal area, flattened facial profile with drooping cheeks, elongated eyelid rims, wide and flattened nasal bridge and turned down corners of the mouth. During the prenatal period, high nuchal translucency and intestinal hyperechogenicity were observed at ultrasound. In conclusion, these two siblings with a novel pathogenic variant in XYLT2 further expand the clinical and mutational spectrum of SOS.
AC093797.1 as a Potential Biomarker to Indicate the Prognosis of Hepatocellular Carcinoma and Inhibits Cell Proliferation, Invasion, and Migration by Reprogramming Cell Metabolism and Extracellular Matrix Dynamics
Authors: Liu Xiaoling , Wang Chenyu , Yang Qing , Yuan Yue , Sheng Yunjian , Li Decheng , Ojha Suvash Chandra , Sun Changfeng , Deng Cunliang 
Published: December 2021

Purpose: The risk signature composed of four lncRNA (AC093797.1, POLR2J4, AL121748.1, and AL162231.4.) can be used to predict the overall survival (OS) of patients with hepatocellular carcinoma (HCC). However, the clinical significance and biological function of AC093797.1 are still unexplored in HCC or other malignant tumors. In this study, we aimed to investigate the biological function of AC093797.1 in HCC and screen the candidate hub genes and pathways related to hepatocarcinogenesis.Methods: RT-qPCR was employed to detect AC093797.1 in HCC tissues and cell lines. The role of AC093797.1 in HCC was evaluated via the cell-counting kit-8, transwell, and wound healing assays. The effects of AC093797.1 on tumor growth in vivo were clarified by nude mice tumor formation experiments. Then, RNA-sequencing and bioinformatics analysis based on subcutaneous tumor tissue was performed to identify the hub genes and pathways associated with HCC.Results: The expression of AC093797.1 decreased in HCC tissues and cell lines, and patients with low expressed AC093797.1 had poor overall survival (OS). AC093797.1 overexpression impeded HCC cell proliferation, invasion, and migration in vitro and suppressed tumor growth in vivo. Compared with the control group, 710 differentially expressed genes (243 upregulated genes and 467 downregulated genes) were filtered via RNA-sequencing, which mainly enriched in amino acid metabolism, extracellular matrix structure constituents, cell adhesion molecules cams, signaling to Ras, and signaling to ERKs.Conclusion: AC093797.1 may inhibit cell proliferation, invasion, and migration in HCC by reprograming cell metabolism or regulating several pathways, suggesting that AC093797.1 might be a potential therapeutic and prognostic marker for HCC patients.
Prevalence and Correlates of Zinc Deficiency Among Vietnamese Women of Reproductive Age in Ho Chi Minh City: A Single Hospital-Based Survey
Authors: Nguyen Vinh Quang , Lam Phong Van , Goto Aya , Nguyen Tu Van T. , Vuong Thanh Nhan T. , Nguyen Tien Minh , Nguyen Minh Ha , Truong Anh Tuyet T. , Tran Truc Phuong T. , Vo Chien Duc 
Published: December 2021

Background and Objectives: Zinc is a micronutrient that plays an important role in metabolism, cell growth regulation, and differentiation. Vietnam has many population groups living in poverty. The daily food of Vietnamese people is mainly rice, which contains very little zinc. This cross-sectional study was conducted to determine the prevalence of, and factors related to, zinc deficiency in women of reproductive age.Methods and Study Design: The sample population was non-pregnant women of reproductive age (18–49 years old) who visited Nguyen Tri Phuong Hospital Gynecological Outpatient Clinic. The subjects were interviewed and data on background characteristics, anthropometric measurements, and blood tests (serum zinc concentration, complete blood count, albumin, and ferritin) were collected.Results: The prevalence of zinc deficiency, as defined by the International Zinc Nutrition Consultative Group (IZiNCG), was 85% [61/72; 95% confidence interval (CI) = 74–91%], and the prevalence of severe zinc deficiency was 37% (27/72; 95% CI = 26–50%). There were significant associations of albumin concentration, marital status, and past pregnancy history with severe zinc deficiency.Conclusions: More than three-fourths of Vietnamese women of reproductive age had zinc deficiency at our study site in Ho Chi Minh City. This health issue requires greater attention in order to swiftly promote preventive actions, and further surveillance to confirm our study findings.