bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost of breast cancer care in low- and middle-income countries: a scoping review protocol
Authors: Erfani Parsa , Bhangdia Kayleigh , Mugunga Jean Claude , Pace Lydia E. , Fadelu Temidayo 
Published: February 2021

ABSTRACT

Objective:
This review will describe the scope of the literature on the cost of breast cancer care in low- and middle-income countries and summate the methodological characteristics and approaches of these economic evaluations.

Introduction:
In the past decade, there has been global momentum to improve capacity for breast cancer care in low- and middle-income countries, which have higher rates of breast cancer mortality compared to high-income countries. Understanding the cost of delivering breast cancer care in low- and middle-income countries is critical to guide effective cancer care delivery strategies and policy.

Inclusion criteria:
Studies that estimate the cost of breast cancer diagnosis and treatment in low- and middle-income countries will be included. Studies not available in English will be excluded.

Methods:
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Review guidelines will be utilized. The search strategy has been developed in consultation with a medical librarian and will be carried out on five electronic databases from their inception (MEDLINE, Embase, Web of Science, Global Health, WHO Global Index Medicus) as well as in gray literature sources. Two independent reviewers will review all abstracts and titles in the primary screen and full-text articles in the secondary screen. A third reviewer will adjudicate conflicts. One reviewer will perform data extraction. Study demographics, design, and methodological characteristics (such as costing perspective, time horizon, and included cost categories) will be summarized in narrative and tabular formats. The methodological quality of studies will be evaluated using a validated economic evaluation tool.
Factors associated with electrical stimulation‐induced performance fatigability are dependent upon stimulation location
Authors: Inns Thomas B. , McCormick Daniel , Greig Carolyn A. , Atherton Philip J. , Phillips Bethan E. , Piasecki Mathew 
Published: February 2021

New Findings

What is the central question of this study?
How does peripheral nerve stimulation (PNS) compare with neuromuscular electrical stimulation (NMES) used clinically to reduce muscle atrophy?

What is the main finding and its importance?
NMES resulted in progressive increases in M‐wave duration and delay of muscle relaxation throughout a single stimulation protocol, findings not observed with PNS. This suggests PNS recruits from a wider pool of muscle fibres/motor units, providing a more favourable alternative to NMES for rehabilitation intervention.

AbstractNeuromuscular electrical stimulation (NMES) is increasingly viewed as a central tenet to minimise muscle loss during periods of disuse/illness – typically applied directly over a muscle belly. Peripheral nerve stimulation (PNS) is afforded less attention, despite providing a more global contractile stimulus to muscles. We investigated NMES versus PNS in relation to performance fatigability and peripheral contributions to voluntary force capacity. Two fatigue protocols were assessed separately: (1) over‐quadriceps NMES and (2) peripheral (femoral) nerve stimulation (PNS). Before and after each session, a maximal voluntary contraction (MVC) was performed to assess force loss. Knee‐extensor force was measured throughout to assess contractile function in response to submaximal electrical stimulation, and M‐wave features quantified myoelectrical activity. NMES and PNS induced similar voluntary (MVC, NMES: −12 ± 9%, PNS: −10 ± 8%, both P < 0.001) and stimulated (NMES: −45 ± 12%, PNS −27 ± 27%, both P < 0.001) force reductions. Although distinct between protocols, myoelectrical indicators of muscle recruitment (M‐wave area and amplitude) and nerve conduction time did not change throughout either protocol. Myoelectrical propagation speed, represented as M‐wave duration, and the delay before muscle relaxation began both progressively increased during NMES only (P < 0.05 and P < 0.001, respectively). NMES myoelectrical changes suggested performance fatigability, indicating activation of superficial fibres only, which was not observed with PNS. This suggests PNS recruits a wider pool of muscle fibres and motor units and is a favourable alternative for rehabilitation. Future work should focus on implementing PNS interventions in clinically relevant scenarios such as immobilisation, care homes and critical illness.
Should We Base Training Prescription on the Force–Velocity Profile? Exploratory Study of Its Between-Day Reliability and Differences Between Methods
Authors: Valenzuela Pedro L. , Sánchez-Martínez Guillermo , Torrontegi Elaia , Vázquez-Carrión Javier , Montalvo Zigor , Haff G. Gregory 
Published: February 2021

Purpose: To analyze the differences in the force–velocity (F–v) profile assessed under unconstrained (ie, using free weights) and constrained (ie, on a Smith machine) vertical jumps, as well as to determine the between-day reliability. Methods: A total of 23 trained participants (18 [1] y) performed an incremental load squat jump test (with ∼35%, 45%, 60%, and 70% of the subjects’ body mass) on 2 different days using free weights and a Smith machine. Nine of these participants repeated the tests on 2 other days for an exploratory analysis of between-day reliability. F–v variables (ie, maximum theoretical force [F0], velocity [v0], and power, and the imbalance between the actual and the theoretically optimal F–v profile) were computed from jump height. Results: A poor agreement was observed between the F–v variables assessed under constrained and unconstrained conditions (intraclass correlation coefficient [ICC] < .50 for all). The height attained during each single jump performed under both constrained and unconstrained conditions showed an acceptable reliability (coefficient of variation < 10%, ICC > .70). The F–v variables computed under constrained conditions showed an overall good agreement (ICC = .75–.95 for all variables) and no significant differences between days (P > .05), but a high variability for v0, the imbalance between the actual and the theoretically optimal F–v profile, and maximal theoretical power (coefficient of variation = 17.0%–27.4%). No between-day differences were observed for any F–v variable assessed under unconstrained conditions (P > .05), but all of the variables presented a low between-day reliability (coefficient of variation > 10% and ICC < .70 for all). Conclusions: F–v variables differed meaningfully when obtained from constrained and unconstrained loaded jumps, and most importantly seemed to present a low between-day reliability.
Prior exercise impairs subsequent performance in an intensity- and duration-dependent manner
Authors: Fullerton Madison M. , Passfield Louis , MacInnis Martin J. , Iannetta Danilo , Murias Juan M. 
Published: February 2021

Prior constant-load exercise performed for 30-min at or above maximal lactate steady state (MLSSp) significantly impairs subsequent time-to-task failure (TTF) compared with TTF performed without prior exercise. We tested the hypothesis that TTF would decrease in relation to the intensity and the duration of prior exercise compared with a baseline TTF trial. Eleven individuals (6 males, 5 females, aged 28 ± 8 yrs) completed the following tests on a cycle ergometer (randomly assigned after MLSSp was determined): (i) a ramp-incremental test; (ii) a baseline TTF trial performed at 80% of peak power (TTFb); (iii) five 30-min constant-PO rides at 5% below lactate threshold (LT−5%), halfway between LT and MLSSp (Delta50), 5% below MLSSp (MLSS−5%), MLSSp, and 5% above MLSSp (MLSS+5%); and (iv) 15- and 45-min rides at MLSSp (MLSS15 and MLSS45, respectively). Each condition was immediately followed by a TTF trial at 80% of peak power. Compared with TTFb (330 ± 52 s), there was 8.0 ± 24.1, 23.6 ± 20.2, 41.0 ± 14.8, 52.2 ± 18.9, and 75.4 ± 7.4% reduction in TTF following LT−5%, Delta50, MLSS−5%, MLSSp, and MLSS+5%, respectively. Following MLSS15 and MLSS45 there were 29.0 ± 20.1 and 69.4 ± 19.6% reductions in TTF, respectively (P < 0.05). It is concluded that TTF is reduced following prior exercise of varying duration at MLSSp and at submaximal intensities below MLSS. Novelty: Prior constant-PO exercise, performed at intensities below MLSSp, reduces subsequent TTF performance. Subsequent TTF performance is reduced in a linear fashion following an increase in the duration of constant-PO exercise at MLSSp.
Partitioning maternal and exogenous diet contributions to otolith 87Sr/86Sr in kokanee salmon (Oncorhynchus nerka)
Authors: Janak Jill M. , Linley Timothy J. , Harnish Ryan A. , Shen Steve D. 
Published: February 2021

Strontium isotopes (87Sr/86Sr) recorded in the otoliths of Pacific salmon (Oncorhynchus spp.) are commonly used to identify natal origin. For species that migrate at or soon after emergence, the embryonic region of the otolith provides the only record of provenance. However, maternal contribution of Sr from the yolk can confound the isotopic signature of the natal site. We experimentally quantified maternal and exogenous diet contributions to otolith 87Sr/86Sr over embryonic development in kokanee salmon (Oncorhynchus nerka). Eggs from two populations in isotopically distinct lakes were incubated and reared in a common water source. Timing of developmental events and proportional contribution from yolk to otolith 87Sr/86Sr differed significantly between the two populations. We suggest that the magnitude of difference in 87Sr/86Sr between yolk and water, the relative concentrations of Sr and Ca in these isotopic sources, and population-specific effects on otolith growth and composition contribute to this variation. Understanding how these factors affect otolith 87Sr/86Sr could extend the use of otolith geochemistry for determining provenance to species and populations in which natal site rearing is limited.
mTOR inhibition as a possible pharmacological target in the management of systemic inflammatory response and associated neuroinflammation by lipopolysaccharide challenge in rats
Authors: Guden Demet Sinem , Temiz-Resitoglu Meryem , Senol Sefika Pinar , Kibar Deniz , Yilmaz Sakir Necat , Tunctan Bahar , Malik Kafait U. , Sahan-Firat Seyhan 
Published: February 2021

Neuroinflammation plays a critical role during sepsis triggered by microglial activation. Mammalian target of rapamycin (mTOR) has gained attraction in neuroinflammation, however, the mechanism remains unclear. Our goal was to assess the effects of mTOR inhibition by rapamycin on inflammation, microglial activation, oxidative stress, and apoptosis associated with the changes in the inhibitor-κB (IκB)-α/nuclear factor-κB (NF-κB)/hypoxia-inducible factor-1α (HIF-1α) pathway activity following a systemic challenge with lipopolysaccharide (LPS). Rats received saline (10 mL/kg), LPS (10 mg/kg), and (or) rapamycin (1 mg/kg) intraperitoneally. Inhibition of mTOR by rapamycin blocked phosphorylated form of ribosomal protein S6, NF-κB p65 activity by increasing degradation of IκB-α in parallel with HIF-1α expression increased by LPS in the kidney, heart, lung, and brain tissues. Rapamycin attenuated the increment in the expression of tumor necrosis factor-α and interleukin-1β, the inducible nitric oxide synthase, gp91phox, and p47phox in addition to nitrite levels elicited by LPS in tissues or sera. Concomitantly, rapamycin treatment reduced microglial activation, brain expression of caspase-3, and Bcl-2-associated X protein while it increased expression of B cell lymphoma 2 induced by LPS. Overall, this study supports the hypothesis that mTOR contributes to the detrimental effect of LPS-induced systemic inflammatory response associated with neuroinflammation via IκB-α/NF-κB/HIF-1α signaling pathway.
Startup Qilimanjaro—towards a European full-stack coherent quantum annealer platform
Authors: Canivell V. , Forn-Díaz P. , Garcia-Saez A. , Sagastizabal R. 
Published: February 2021

AbstractQilimanjaro Quantum Tech is the full-stack quantum spin-off of three research institutions, the Barcelona Supercomputing Center (BSC), the Institute for High Energy Physics (IFAE) and the University of Barcelona (UB). The company addresses the emerging quantum readiness demand from industry and academia, by providing both algorithmic development services as well as access to a new coherent quantum annealer platform, a special purpose quantum computer. Qilimanjaro is a member of the AVaQus European Commission’s H2020 FET-Open consortium for coherent quantum annealing development, which is led by one of Qilimanjaro’s founders at IFAE. A special feature of Qilimanjaro are its funding sources being exclusively international client contracts.
Efficacy of pyonex in the treatment of functional dyspepsia with mild to moderate depression
Authors: Ye Qing , Chen Xiqun , Li Hui , Hu Yuqing , Zhou Jie , Gao Chen 
Published: February 2021

Objective: To observe efficacy of pyonex in the treatment of functional dyspepsia (FD) with mild to moderate depression.Methods: 64 FD patients with mild to moderate depression were randomly divided into control group ([Formula: see text]) and test group ([Formula: see text]). The test group was given mosapride combined with pyonex, acupuncture at Neiguan, Shenmen, Zusanli and Taichong, and the control group was given mosapride combined with sertraline. The course of treatment was 4 weeks in both groups. The changes of LDQ and HAMD scores were compared between the two groups before and after treatment, and the safety and efficacy were evaluated.Results: ① LDQ scores: The total efficacy of the test group was 87.5%, and that of the control group was 81.3% after treatment. The curative effect of the test group was similar to that of the control group ([Formula: see text]). The total LDQ scores and single symptom scores of the test group were significantly better than those of the control group ([Formula: see text]). ② HAMD scores: The both groups were significantly improved as compared with those before treatment ([Formula: see text]). ③ Safety evaluation: There were no obvious adverse reactions in the two groups during the treatment.Conclusions: Pyonex combined with mosapride can be safe and may improve the clinical symptoms of dyspepsia and depression.
Empirical evidence for cognitive subgroups in body dysmorphic disorder
Authors: Malcolm Amy , Brennan Sarah N , Grace Sally A , Pikoos Toni D , Toh Wei Lin , Labuschagne Izelle , Buchanan Ben , Kaplan Ryan A , Castle David J , Rossell Susan L 
Published: February 2021

Objective: Current understanding of cognitive functioning in body dysmorphic disorder is limited, owing to few studies, small sample sizes and assessment across only limited cognitive domains. Existing research has also shown inconsistent findings, with both intact and impaired cognition reported in body dysmorphic disorder, which might point towards cognitive heterogeneity in the disorder. This study aimed to examine the cognitive profile of body dysmorphic disorder in a large sample across eight cognitive domains, and to explore whether cognitive subgroups might be identified within body dysmorphic disorder. Method: Cognitive domains of inhibition/flexibility, working memory, speed of processing, reasoning and problem-solving, visual and verbal learning, attention/vigilance and social cognition were assessed and compared between 65 body dysmorphic disorder patients and 70 healthy controls. Then, hierarchical clustering analysis was conducted on the body dysmorphic disorder group’s cognitive data. Results: Group-average comparisons demonstrated significantly poorer cognitive functioning in body dysmorphic disorder than healthy controls in all domains except for attention/vigilance and social cognition. Cluster analysis identified two divergent cognitive subgroups within our body dysmorphic disorder cohort characterised by (1) broadly intact cognitive function with mild selective impairments (72.3%), and (2) broadly impaired cognitive function (27.7%). However, the clusters did not significantly differ on clinical parameters or most sociodemographic characteristics. Conclusion: Our findings demonstrate considerable cognitive heterogeneity among persons with body dysmorphic disorder, rather than uniform deficits. Poor performances in the broadly impaired subgroup may have driven group-level differences. However, our findings also suggest a dissociation between cognitive functioning and clinical characteristics in body dysmorphic disorder that has implications for current aetiological models. Additional research is needed to clarify why some people with body dysmorphic disorder demonstrate cognitive deficits while others do not.
Prevalence and characteristics of women with borderline personality pathology referred to a perinatal consultation liaison service
Authors: Nagel Katharina , Thomson Richard , Lorimer Stephanie , Judd Fiona 
Published: February 2021

Objective: To examine the prevalence and characteristics of pregnant women with borderline personality pathology (defined as borderline personality disorder and borderline personality traits) referred to a perinatal consultation-liaison psychiatry service. Method: Socio-demographic and clinical data, and diagnoses made according to Diagnostic and Statistical Manual of Mental Disorders (5th ed.) criteria were recorded for all women referred to and seen by the perinatal consultation-liaison psychiatry service over an 18-month period. Data were analysed using descriptive statistics and logistic regression analysis. Results: A total of 318 women were seen. The most common diagnoses found were depressive disorder (25.5%) and anxiety disorder (15.1%). Borderline personality disorder was found in 10.1% of women and almost one in five women had two or more borderline personality traits (19.5%). When compared to women with other diagnoses, women with borderline personality pathology had higher rates of unplanned pregnancy, being unpartnered, substance use during pregnancy and higher rates of child safety services involvement as a child or in a previous pregnancy. Over 40% of women with borderline personality pathology were referred to child safety services in the current pregnancy and a diagnosis of borderline personality pathology increased the risk of child safety services involvement by almost sixfold (odds ratio: 5.5; 95% confidence interval = [1.50, 20.17]). Conclusion: The prevalence of borderline personality pathology in antenatal women identified at antenatal screening and the recognition that women with borderline personality pathology are ‘high-risk’ caregivers argue for borderline personality pathology to be recognised as a high priority for investment in service development.
Results and outcomes for patients with atrioventricular groove disruption after mitral valve surgery
Authors: Ivanov Borko , Djordjevic Ilija , Eghbalzadeh Kaveh , Schlachtenberger Georg , Gerfer Stephen , Gaisendrees Christopher , Kuhn Elmar , Rahmanian Parwis , Sabashnikov Anton , Mader Navid , Wahlers Thorsten 
Published: February 2021

Background: Atrioventricular groove disruption (AVGD) is a rare and severe complication of mitral valve surgery (MVS). Current literature is limited to several case reports and series. Our aim was to analyze outcomes of patients with AVGD after MVS from our tertiary cardiac surgery center. Methods: Between June 2010 and January 2019, 18 patients suffering AVGD were identified in our institutional database and included in our retrospective observation. Preoperative, intraoperative and outcome data were analyzed using IBM SPSS Statistics. Late survival was estimated by using the Kaplan–Meier survival analysis. Results: The mean age of the study population was 76 ± 5 years. Most common indication for MVS was an isolated mitral valve insufficiency (67%). Severe annular calcification was present in four patients (22%). Majority of implanted valves were biological prosthesis (78%). Due to the location, 72% suffered type I rupture. External repair was performed in 94% of all patients. Second look operation in regard of excessive mediastinal hemorrhage was necessary in 67% of patients. Mean hospital stay of the presented collective was 13 ± 11 days with an intra-hospital mortality of 56%. Late follow-up was obtained in eight patients at an average of 3.1 (1.6–5.7) years postoperatively. Conclusion: Mortality rates for AVGD after MVS are high. However, way of managing AVGD depends on the underlying type of rupture and should be evaluated in regard of the myocardial damage. Due to the rare occurrence, registry data might help to address more scientific value concerning therapeutic measures and outcomes of this severe complication.
Influence of iron deficiency anemia on glycated hemoglobin levels in non-diabetic Saudi women
Authors: Bindayel Iman Abdullah 
Published: February 2021

Objective Studies of patients with iron deficiency anemia (IDA) have shown a relationship between high glycated hemoglobin (HbA1c) and low hemoglobin (Hb) concentration. The present study was conducted to determine the influence of IDA on HbA1c in non-diabetic women. Methods Fifty-nine Saudi women (20 to 50 years old) were enrolled and categorized into groups according to their circulating hemoglobin concentration: Non-IDA (Hb ≥7.45 mmol/L; n = 38) and IDA (Hb ≤7.44 mmol/L; n = 21). The IDA group was further subdivided according to the severity of the IDA, as follows: mild (Hb 6.83 to 7.44 mmol/L; n = 9) and moderate–severe (Hb <6.83 mol/L; n = 12). HbA1c, Hb, ferritin, fasting blood glucose, and red blood cell (RBC) count were measured in each participant. Results HbA1c did not significantly differ between the groups, but the absolute HbA1c level was significantly lower in the mild and moderate–severe anemia groups than the non-anemic group, and was positively associated with Hb, ferritin, and RBC count. In addition, the HbA1c level was inversely associated with the Hb concentration. Conclusions HbA1c is significantly associated with parameters related to IDA in non-diabetic Saudi women. Therefore, assessment of IDA-related parameters is recommended prior to making a diagnosis of diabetes.
Characteristics, complications, and outcomes of early-stage cervical stump carcinoma: laparoscopy versus laparotomy
Authors: Lu Zhiying , Guo Chenyan , Wang Ting , Qiu Junjun , Hua Keqin 
Published: February 2021

Objective To compare the characteristics, surgical complications, and overall survival between patients undergoing laparoscopy versus laparotomy for treatment of early-stage cervical stump carcinoma. Methods Patients with International Federation of Gynecology and Obstetrics (FIGO, 2009) stage IA2 to IIA2 cervical stump carcinoma who underwent laparoscopy or laparotomy in the Obstetrics and Gynecology Hospital of Fudan University from January 2000 to June 2018 were retrospectively reviewed. All patients’ clinical characteristics, pathological features, complications, and follow-up data were retrieved. Results Seventy-two patients were included in the analysis; 58 underwent laparoscopy and 14 underwent laparotomy. With respect to surgical complications, laparoscopy was associated with a significantly lower complication rate, less blood loss, a shorter operative time, and a higher hospitalization fee than laparotomy. Survival was not significantly different between the laparoscopy and laparotomy groups. Conclusions Although survival was not significantly different between the two surgical approaches, the rate of surgical complications was much lower in the laparoscopy than laparotomy group.