bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conversation with the Twenty-First Century Social Work: Some ‘Post(s)’ Perspectives
Authors: Yadav Raj 
Published: October 2021

AbstractThis article explores ‘post(s)’ perspective understandings for the 21st century social work. Drawing mainly on post-debates, this article argues that human beings and their societies will evolve in unimagined ways in the future than these have been in all of their previous historical periods. Social work therefore must re-invent and re-adjust itself in the rest of the 21st century. Such re-invention and re-adjustment, however, will pivot around some complex theoretical narratives concerning to the ‘post(s)’ contexts and conditions of the 21st century.
Onset pattern of nigrostriatal denervation in early Parkinson’s disease
Authors: Pineda-Pardo José A , Sánchez-Ferro Álvaro , Monje Mariana H G , Pavese Nicola , Obeso José A 
Published: October 2021

Abstract
The striatal dopaminergic deficit in Parkinson’s disease exhibits a typical pattern, extending from the caudal and dorsal putamen at onset to its more rostral region as the disease progresses. Clinically, upper-limb onset of cardinal motor features is the rule. Thus, according to current understanding of striatal somatotopy (i.e. the lower limb is dorsal to the upper limb) the assumed pattern of early dorsal striatal dopaminergic denervation in Parkinson’s disease does not fit with an upper-limb onset. We have examined the topography of putaminal denervation in a cohort of 23 recently diagnosed de novo Parkinson’s disease patients and 19 age-/gender-matched healthy subjects assessed clinically and by 18F-DOPA PET; 15 patients were re-assessed after 2 years. There was a net upper-limb predominance of motor features at onset. Caudal denervation of the putamen was confirmed in both the more- and less-affected hemispheres and corresponding hemibodies. Spatial covariance analysis of the most affected hemisphere revealed a pattern of 18F-DOPA uptake rate deficit that suggested focal dopamine loss starting in the posterolateral and intermediate putamen. Functional MRI group-activation maps during a self-paced motor task were used to represent the somatotopy of the putamen and were then used to characterize the decline in 18F-DOPA uptake rate in the upper- and lower-limb territories. This showed a predominant decrement in both hemispheres, which correlated significantly with severity of bradykinesia. A more detailed spatial analysis revealed a dorsoventral linear gradient of 18F-DOPA uptake rate in Parkinson’s disease patients, with the highest putamen denervation in the caudal intermediate subregion (dorsoventral plane) compared to healthy subjects. The latter area coincides with the functional representation of the upper limb. Clinical motor assessment at 2-year follow-up showed modest worsening of parkinsonism in the primarily affected side and more noticeable increases in the upper limb in the less-affected side. Concomitantly, 18F-DOPA uptake rate in the less-affected putamen mimicked that recognized on the most-affected side. Our findings suggest that early dopaminergic denervation in Parkinson’s disease follows a somatotopically related pattern, starting with the upper-limb representation in the putamen and progressing over a 2-year period in the less-affected hemisphere. These changes correlate well with the clinical presentation and evolution of motor features. Recognition of a precise somatotopic onset of nigrostriatal denervation may help to better understand the onset and progression of dopaminergic neurodegeneration in Parkinson’s disease and eventually monitor the impact of putative therapies.
Aphasia localization: was Pierre Marie right?
Authors: Coutinho Léo , Caramelli Paulo , Teive Hélio A Ghizoni 
Published: October 2021

Abstract
Language and its associated disorders have puzzled humanity since the dawn of civilization. The first descriptions of aphasia go back to classical antiquity. The Egyptians and Babylonians believed speech was a divine gift to mortals, and their descriptions of aphasia attributed these events to their Gods’ anger and disfavour. The Edwin Smith Surgical Papyrus and the Hippocratic Corpus report several aphasia cases, relating this phenomenology to apoplexy, epilepsy, and other illnesses.
Hepatocellular carcinoma risk variant modulates lncRNA HLA-DQB1-AS1 expression via a long-range enhancer–promoter interaction
Authors: Wang Haoxue , Yang Beifang , Cai Xiaomin , Cheng Xiang , Shen Na , Liu Li , Li Jiaoyuan , Wang Ying , He Heng , Ying Pingting , Li Bin , Lu Zequn , Yang Nan , Wang Xiaoyang , Zhang Fuwei , Li Yanmin , Wang Wenzhuo , Ning Caibo , Zhu Ying , Chang Jiang , Miao Xiaoping , Tian Jianbo , Zhong Rong 
Published: October 2021

Abstract
Substantial evidence highlighted the critical role of long non-coding RNAs (lncRNA) in driving hepatocarcinogenesis. We hypothesized that functional variants in genome-wide association studies (GWASs) associated loci might alter the expression levels of lncRNAs and contribute to the development of hepatocellular carcinoma (HCC). Here, we prioritized potentially cis-expression quantitative trait loci-based single nucleotide polymorphism (SNP)-lncRNA association together with the physical interaction by the analyses from Hi-C data in GWAS loci of chronic hepatitis B and HCC. Subsequently, by leveraging two-stage case-control study (1738 hepatitis B [HBV]) related HCC cases and 1988 HBV persistent carriers) and biological assays, we identified that rs2647046 was significantly associated with HCC risk (odds ratio = 1.26, 95% CI = 1.11 to 1.43, P = 4.14 × 10−4). Luciferase reporter assays and electrophoretic mobility shift assays showed that rs2647046 A allele significantly increased transcriptional activity via influencing transcript factor binding affinity. Allele-specific chromosome conformation capture assays revealed that enhancer with rs2647046 interacted with the HLA-DQB1-AS1 promoter to allele-specifically influence its expression by CTCF-mediated long-range loop. Cell proliferation assays indicated that HLA-DQB1-AS1 is a potential oncogene in HCC. Our study showed HLA-DQB1-AS1 regulated by a causal SNP in a long-range interaction manner conferred the susceptibility to HCC, suggesting an important mechanism of modulating lncRNA expression for risk-associated SNPs in the etiology of HCC.
Utility and Applicability of Rapid Diagnostic Testing in Antimicrobial Stewardship in the Asia-Pacific Region: A Delphi Consensus
Authors: Apisarnthanarak Anucha , Bin Kim Hong , Moore Luke S P , Xiao Yonghong , Singh Sanjeev , Doi Yohei , Kwa Andrea Lay-Hoon , Ponnampalavanar Sasheela Sri La Sri , Cao Qing , Kim Shin-Woo , Lee Hyukmin , Santanirand Pitak 
Published: October 2021

Abstract
Rapid diagnostic tests (RDTs) facilitate fast and accurate identification of infectious disease microorganisms and are a valuable component of multimodal antimicrobial stewardship (AMS) programs but are currently underutilized in the Asia-Pacific region. An experienced group of infectious diseases clinicians, clinical microbiologists, and a clinical pharmacist used a modified Delphi consensus approach to construct 10 statements, aiming to optimize the utility and applicability of infection-related RDTs for AMS in the Asia-Pacific region. They provide guidance on definition, types, optimal deployment, measuring effectiveness, and overcoming key challenges. The Grading of Recommendations Assessment, Development, and Evaluation system was applied to indicate the strength of the recommendation and the quality of the underlying evidence. Given the diversity of the Asia-Pacific region, the trajectory of RDT development will vary widely; the collection of local data should be prioritized to allow realization and optimization of the full benefits of RDTs in AMS.
Mitigating Institutional Attitudes toward Sign Languages: A Model for Language Vitality Surveys
Authors: Webster Jenny 
Published: October 2021

AbstractThis paper is about attitudes toward sign languages. The paper presents an idea to help make sign language surveys better in the future. In 2018, UNESCO (the United Nations Educational, Scientific and Cultural Organization) published a sign language survey and a spoken language survey together for the first time. This was very important to show that spoken languages and signed languages are equal. But the sign language survey has some weaknesses. The idea presented in this paper says that: when people make sign language surveys, they should be aware of discrimination and negative attitudes; they should give signers access to the survey in sign language; and they should help signers decide what actions they can do to protect their sign language.
Intravascular ultrasound for peri-procedural geometric orifice area measurement during transcatheter pulmonary valve replacement
Authors: Kalinczuk L , Wozniak O , Mintz G S , Rynkiewicz K , Skotarczka W , Zielinski K , Michalowska I , Biernacka K , Ruzyllo W , Demkow M 
Published: October 2021

Abstract

Introduction
Large imaging filed intravascular ultrasound (IVUS) offering superior online tomographic perspective and visual accuracy could guide transcatheter pulmonary valve replacement (TPVR) for right ventricular outflow tract (RVOT) insufficiency. It is unknown whether geometric orifice area (GOA) measured by IVUS corresponds with effective orifice area (EOA) measure by transthoracic echocardiography (TTE) after successful TPVR.

Purpose
To compare minimal inner-leaflets cross-sectional area delineated in systole (min GOA) measured by IVUS versus EOA calculated = right ventricle stroke volume (measured in baseline cardiac magnetic resonance) / pulmonary valve velocity time integral (measured early post-procedure by Vivid e95).

Methods
After successful TPVR a 10MHz Vision PV 0.035" (60mm imaging field) IVUS catheter was slowly pulled from the distal pulmonary artery to the right ventricle with continuous imaging of RVOT. IVUS measurements included inner-valve dimension for several evenly spaced cross-sections along the entire length and perpendicular to RVOT long axis. Measured were outer-frame diameters (minimal and maximal) and its cross-sectional area, and cross-sectional area of the visual orifice (min GOA) identified exclusively at the coaptation site (Fig 1).

Results
There were 11 pts (median age 30 [25–36] yrs, 4 ♀, all but one with Tetralogy of Fallot) who had undergone prior corrective surgery (5 transannular patch, 2 bioprosthetic valve or 4 pulmonary homograft). Overall, 176 cross-sections were analyzed. Overall, min GOA measured 3.7±1.0cm2, and was 68%±9% of the valve-outer area (5.5±1.5cm2). It was substantially larger than calculated EOA (3.7±1.0cm2 vs 2.0±0.5cm2; p&lt;0.001). The ratio of max/min GOA diameter was 1.11±0.11 signifying low eccentricity and was not related to EAO.

Conclusions
After successful balloon-expandable valve implantation to treat RVOT insufficiency, geometric orifice dimension was significantly smaller then outer valve frame dimension. Visual measure of geometric orifice area during the procedure using IVUS documented its circularity and indicated that it was larger than EOA calculated upon functional measure.

Funding Acknowledgement
Type of funding sources: Public hospital(s). Main funding source(s): This work was supported by the research grant (2.4/VI/18) founded by the National Institute of Cardiology in Warsaw (Poland). IVUS visualization of ES3.
Three-dimensional echocardiography in transcatheter edge-to-edge tricuspid valve repair
Authors: Orban M , Wolff S , Stolz L , Braun D , Stark K , Mehr M , Stocker T , Orban M , Hagl C , Massberg S , Nabauer M , Hausleiter J 
Published: October 2021

Abstract

Background
Transcatheter tricuspid valve repair (TTVR) is a new treatment option for severe tricuspid regurgitation (TR). First reports have reported conflicting results on development of right ventricular (RV) function after TTVR and questioned the role of conventional echocardiographic parameters to predict outcome.

Purpose
The aim of this study was to evaluate 3D echocardiography for the comprehensive assessment of RV function and its prognostic value for TTVR-treated patients.

Methods
We included patients undergoing TTVR from February 2017 to July 2019 who had preprocedural 3D assessment of RV volumes and ejection fraction. At follow-up (FU), 3D echo was performed to evaluate right ventricular reverse remodeling. All-cause mortality was assessed as clinical endpoint.

Results
75 patients treated with TTVR for isolated, severe TR had 3D echo assessment. TTVR reduced TR from grade ≥3+ to ≤2+ in 83.1% of patients at discharge. 3D-RV end-diastolic volume (−46.3 ml, p&lt;0.001), end-systolic volume (−22.0 ml, p=0.027) and 3D-RV ejection fraction (−4.7%, p&lt;0.001) decreased at short-term FU at 1-month and remained stable at 6-month FU. An impaired preprocedural 3D-RVEF &lt;44% conferred higher mortality risk (Figure), and was an independent predictor for 1-year mortality (hazard ratio 5.32, p=0.033) in multivariable analysis. Tricuspid annular systolic excursion (TAPSE) and RV fractional area change were not predictive for this endpoint. Importantly, the observed decrease of 3D-RVEF function after TTVR was not associated with outcome (p=0.22 for decrease of 3D-RVEF vs. no decrease of 3D-RVEF in Kaplan-Meier analysis). Instead, left ventricular stroke volume index increased by 9.2% from 26.0 to 28.4 ml/m2 (p&lt;0.01)

Conclusion
TTVR leads to right ventricular reverse remodeling and decrease of RV systolic function after TTVR. Impaired preprocedural RV systolic function is associated with worse clinical outcome. In contrast, the observed decrease of RV systolic function after TTVR was not associated with outcome.

Funding Acknowledgement
Type of funding sources: Public hospital(s). Main funding source(s): Klinikum der Universtität München Figure 1
Genetic polymorphisms of interleukin-6 and interleukin-10 are not associated with new onset atrial fibrillation after coronary artery bypass graft surgery
Authors: Rubanenko O , Shchukin Y , Rubanenko A 
Published: October 2021

Abstract

Purpose
To estimate the association of the genetic polymorphisms of Interleukin-6 (IL-6) and Interleukin-10 (IL-10) with new onset atrial fibrillation (AF) in postoperative period of coronary artery bypass graft (CABG) surgery in patients with coronary artery disease (CAD).

Methods
Studied were 158 patients who underwent CABG. In all the patients routine laboratory and instrumental tests were performed. Patients also underwent genetic polymorphisms of IL-6 C174G, IL-10 C592A and IL-10 G1082A estimation. All the patients were divided into two groups: 1 group comprised 111 patients without AF (82.0% men, median age 62.0 (56.0; 66.0) years, 2 group - 47 patients with AF development after CABG (84.4% men, median age 65.0 (61.0; 70.0) years).

Results
During the observation period AF occurred in 29.7% patients, on average 5.2 (2.0; 7.0) days after surgery. Patients of group 2 had longer history of CAD (60.0 (13.5; 138.0) vs. 15.5 (8.0; 72.0) months, p=0.01), had more often NYHA III class (27.7% vs. 9.0%, p=0.002) and larger left atrial (LA) diameter (44.0 (40.5; 46.0) mm vs. 38.0 (36.0; 40.0) mm, p&lt;0.0001) comparing with group 1.
Genotype CC IL-6 C174G was found in 19.8% patients of the 1 group and in 25.5% patients of the 2 group (p=0.42), genotype CG - in 56.8% and 53.2% (p=0.68), genotype GG - in 23.4% and 21.3% (p=0.77) respectively. Genotype CC IL-10 C592A was found in 62.2% patients of the 1 group and 46.8% patients of the 2 group (p=0.29), genotype CA - in 37.8% patients of the 1 group and in 53.2% patients of the 2 group (p=0.07) respectively. Genotype GG IL-10 G1082A was found in 25.2% patients of the 1 group and 23.4% patients of the 2 group (p=0.8), genotype GA - in 48.6% patients of the 1 group and in 59.6% patients of the 2 group (p=0.2), genotype AA - in 26.2% patients of the 1 group and in 17.0% patients of the 2 group (p=0.3) respectively.
All estimated genotypes fulfilled expectations of Hardy-Weinberg equilibrium.
According to the result of multivariate regression analysis the odds ratio for AF development in postoperative period of CABG for history of CAD more than 20 months - 1.1 (95% CI, 1.03–1.2, p=0.04), for LA dimension more than 41 mm - 1.5 (95% CI, 1.28–1.79, p&lt;0.0001).

Conclusion
Our investigation showed that increased left atrial dimension and the history of coronary artery disease were associated with postoperative atrial fibrillation development in patients who underwent coronary artery bypass graft surgery. However, genetic polymorphisms of IL-6 C174G, IL-10 C592A and IL-10 G1082A were not significantly associated with postoperative atrial fibrillation development.

Funding Acknowledgement
Type of funding sources: None.
Low voltage in limb leads in arrhythmogenic cardiomyopathy
Authors: Peters S 
Published: October 2021

Abstract

Low voltage in limb leads characterizes left ventricular involvement in arrhythmogenic cardiomyopathy. A large collective of patients with arrhythmogenic cardiomyopathy including 438 patients (268 males, mean age 46.8±11.6 years) were analyzed.

Method
Low voltage in limb leads were analyzed in typical patients with arrhythmogenic cardiomyopathy. Several other ECG features such a slow voltage in precordial leads, epsilon waves, right precordial T wave inversions, QRS fragmentation, typical appearance in lead aVR, amplitude of T wave inversion in special right ventricular leads, and developing complete right bundle branch block.

Results
Low voltage in limb leads was found in 60 patients (15%). Two patients represented with low voltage in limb leads and T wave inversions in inferolateral leads charactizing arrhythmogenic left ventricular leads with moderate reduction of left ventricular function with a large aneurysm of the apex. The other patients presented with sustained RBBB-VT. In 38 patients low voltage in limb leads and typical ECG findings of arrhythmogenic cardiomyopathy were found. These patients had arrhythmogenic biventricular cardiomyopathy of moderate reduction of left ventricular function and typical arrhythmias. Low voltage in limb and precordial leads was found in 14 patients with two cardiac deaths due to therapy-resistant heart failure. In 6 cases low voltage in limb and precordial leads and developing complete right bundle branch block were found. Four patients were tranplanted, two cases died due to heart failure. These 20 patients characterize advances, end-stage disease arrhythmogenic cardiomyopathy.

Conclusion
Standard ECG can differentiate between arrhythogenic left ventricular, arrhythmogenic biventricular, and arrhythmogenic advanced end-stage cardiomyopathy

Funding Acknowledgement
Type of funding sources: None.
Microvolt t-wave alternans its clinical significance in the assessment of the risk of sudden cardiac death among patients with hypertrophic cardiomyopathy
Authors: Pawlak M , Trzos E , Kurpesa M 
Published: October 2021

Abstract

Summary
Some patients with hypertrophic cardiomyopathy (HCM) are at significant risk of premature sudden death. Identification of the risk factors may enable effective prevention of adverse cardiac events in these patients. Assessment of the microvolt T-wave alternans (MTWA) is a recognized non-invasive diagnostic test used in risk stratification of sudden cardiac death (SCD). However, the number of reports on the frequency of occurrence of MTWA in HCM is small. Aim: Evaluation of the prognostic value of MTWA in predicting the risk of arrhythmic events (sudden cardiac death, documented VT/VF, appropriate ICD discharge) in patients with HCM.

Material and methods
122 patients with HCM underwent detailed clinical assessment and ECG- and echocardiographic examination. They underwent 24-hour ambulatory ECG monitoring, and the following elements were analysed: 1) arrhythmias, 2) heart rate variability (HRV) and the QT segment, 3) the presence of ventricular late potentials (LP), 4) heart rate turbulence (HRT). MTWA assessment was made during a test on a treadmill (Cambridge Heart). In accordance with the adopted criteria, the test was interpreted as negative, positive or indeterminate. Subsequently, positive and indeterminate results were described collectively as MTWA(+) and negative results as MTWA(−). Then the patients were divided into two groups: Group 1 – 57 patients (46,7%) with MTWA(−), and Group 2 – 65 patients (53,2%) with MTWA(+). In order to stratify the risk, the following were adopted as composite primary endpoints: sudden cardiac death or hospitalization for life-threatening arrhythmias (VT/VF), and appropriate ICD discharge.

Results
The mean follow-up period of the patients was 57±8 months; during that time, events that met the criteria for the endpoint occurred in 16 patients. On the basis of univariate analysis, 10 variables with a significant influence on the occurrence of an event were selected (unexplained syncope, NT-proBNP values elevated above 411 pg/ml, size of the left atrium over 44mm, diastolic thickness of the interventricular septum over 25 mm, the presence of MTWA(+), the QRS width &gt;90 msec, QTc &gt;467 msec, QTd &gt;70 msec, SDNN &lt;110 msec, and sinus rhythm turbulence parameters TS &lt;2,9 ms/2RR). These variables were then included in a multivariate analysis. The model from a Cox regression analysis showed that the presence of unexplained syncope (HR=1,4), MTWA(+) (HR=1,5), size of the left atrium over 44mm (HR=5), and the thickness of the interventricular septum over 25 mm (HR=1,5) increased the risk of sudden events.

Conclusions
1) Patients with hypertrophic cardiomyopathy had a significant percentage of positive results of the microvolt T-wave alternans test (MTWA+), 2) Positive MTWA test result in patients with hypertrophic cardiomyopathy can help to identify patients at risk of sudden cardiac death.

Funding Acknowledgement
Type of funding sources: None.