bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and efficacy of methotrexate (0.3 mg/kg/week) versus a combination of methotrexate (0.15 mg/kg/week) with cyclosporine (2.5 mg/kg/day) in chronic plaque psoriasis: A randomised non-blinded controlled trial
Authors: Singh Satyendra Kumar , Singnarpi Sermili Rini 
Published: March 2021

Background:
Psoriasis is a chronic, inflammatory, relapsing and remitting disease with no cure till date. There is a paucity of trials using a combination of methotrexate (MTX) and cyclosporine (CsA) in chronic plaque psoriasis, due to fear of added toxicity, although they are time tested treatment options for monotherapy.

Aims:
The study aimed to compare the efficacy and adverse effect profile of the standard recommended dose of MTX (i.e. 0.3mg/kg/week) versus a combination of reduced doses of MTX and CsA (i.e. MTX 0.15 mg/kg/week with CsA 2.5mg/kg/day) in patients with chronic plaque psoriasis.

Methods:
Study design was a non-blinded randomised controlled trial. Patients of chronic plaque psoriasis with PASI more than 10 were randomised in 1: 1 allocation to receive either 0.3 mg/kg/week of intramuscular MTX injection or a combination of 0.15 mg/kg/week of intramuscular MTX injection and 2.5 mg/kg/day of CsA rounded off to the nearest 25 mg. Patients were followed up at every 2 weeks for 12 weeks. The doses were kept fixed throughout the study period.

Results:
A total of 66 patients received MTX monotherapy, whereas 67 patients received the combination. At baseline, both groups were comparable in their BSA (P = 0.105, Student t-test) and PASI (P = 0.277, Student t-test), which reduced significantly at 12 weeks in both groups (P < 0.001, paired t-test). The achievement of PASI-75 (P = 0.005), PASI-90 (P < 0.001) and PASI-100 (P = 0.001) was more in the combination group (Chi square test). Intention to treat analysis using Chi square test also showed better outcomes for PASI-75 (P = 0.027), PASI-90 (P < 0.001) and PASI-100 (P = 0.001) in the combination group. Combination group also had earlier onset of action (P = 0.001, Chi square test). There was no significant difference between the groups in terms of laboratory and clinical adverse events.

Limitations:
Non-blinded, no comparison with CsA monotherapy arm, no follow up beyond 12 weeks.

Conclusion:
The combination of reduced doses of MTX and CsA is more efficacious with earlier onset of action and similar adverse effects as with MTX monotherapy.
Letting Bodies be Bodies: Exploring Relaxed Performance in the Canadian Performance Landscape
Authors: LaMarre Andrea , Rice Carla , Besse Kayla 
Published: March 2021

There is an increasing movement toward accessibility in arts spaces, including recent legislative changes and commitments at individual, organizational, and systemic levels to integrating access into the arts across Canada. In this article, we explore Relaxed Performance (RP) in the context of this movement. We present the results of a reflexive thematic analysis of interviews conducted with participants who completed RP training offered by the British Council to . understand the training’s effectiveness and impact. We explore the significance of the training, and of RP in general, and in relation to disability studies and cultural and political activism. We undertake this exploration against a backdrop of interrogating who RP is for and by. The themes we describe are: Committed to Access, Training is Critical, Inviting Bodies to be Bodies, and Imagining Audiences. These themes tell a story of how RP relates to broader access work, the importance of training grounded in and led by disability/difference, the need to consider the relationships between bodies and spaces, and the tensions inherent to billing RP as “for all.” We conclude with an exploration of possible modifications, enhancements, or theoretical imaginings that could help RP to become more radically open to difference as it emerges, shifts, and changes.
JOGOS DE LINGUAGEM E GEOMETRIA EUCLIDIANA PLANA: UMA TERAPIA WITTGENSTEINIANA EM CURSOS DE LICENCIATURA EM MATEMÁTICA
Authors: Moreira Person Gouveia dos Santos , Pinto Thiago Pedro 
Published: March 2021

Este trabalho reporta uma investigação, a partir da dúvida de a geometria euclidiana plana ser abordada de modo diferente em livros distintos, utilizados na formação de professores de matemática na Universidade Federal de Mato Grosso do Sul – UFMS. Assim, com base no levantamento de ementas e bibliografias de disciplinas de geometria nos cursos de Licenciatura em Matemática da UFMS, foram analisados os livros Geometria Euclidiana Plana, de João Lucas Barbosa (2006), que vinha sendo utilizado por muitos anos em praticamente em todos os cursos de Licenciatura em Matemática, da referida Universidade e, por questões logísticas, foi substituído por Geometria Euclidiana Plana e Construções Geométricas, de Eliane Quelho Frota Rezende e Maria Lúcia Bontorim de Queiroz (2000), em busca de semelhanças e diferenças entre ambos. Ancorada na perspectiva dos jogos de linguagem de Ludwig Wittgenstein, a referida análise desses dois manuais pautou-se na averiguação de como se constituíam os jogos de linguagem nestes manuais. Para tanto, foi praticada uma Terapia Bibliográfica com a Geometria Euclidiana Plana, seus axiomas, postulados e teoremas, tendo em conta que jogos de linguagem estão sempre assentados em formas de vida. Assim a leitura se inspirou em possíveis usos destes manuais didáticos em salas de aula de formação de professores de Matemática. Foram constatadas várias dessemelhanças, tais como diferentes palavras usadas em um mesmo sentido, usos de uma mesma palavra de formas próprias e encadeamentos lógicos singulares, caracterizando, assim, diferentes jogos de linguagem, diferentes Geometrias Euclidianas Planas.
Previous Malignancy as a Risk Factor for the Second Solid Cancer in a Cohort of Nuclear Workers
Authors: Osipov Mikhail , Sokolnikov Mikhail 
Published: March 2021

This paper describes the results of epidemiological analysis of a cohort of nuclear workers hired at the main facilities of “Mayak” Production Association located in the city of Ozyorsk in Southern Urals of the Russian Federation. Previous malignancy as a risk factor for second cancer in a cohort of 22,373 workers occupationally exposed to ionizing radiation has been analyzed in a retrospective study with more than 60 years of follow-up. Information on main radiation and non-radiation risk factors (attained age, sex, tobacco smoking), as well as the dose of exposure to occupational ionizing radiation has been obtained for the analysis using the data from cancer register as well as other main population registries created in Epidemiological Laboratory of Southern Urals Biophysics Institute. Poisson’s regression realized in the “Amfit” module of “Epicure” statistical package has been applied for risk analysis. Excess relative risk per 1 Gy of absorbed dose of external gamma radiation and internal alpha radiation has been calculated using linear model. Among the 2,471 cancer cases accumulated in the study cohort to the end of follow-up 6.4% of second cancer cases have been diagnosed among workers occupationally exposed to protracted external gamma- and internal alpha radiation. The relative risk of second cancer (except for non-melanoma skin cancer) among nuclear workers with previously diagnosed cancer was about 4 times higher after a decade compared with those cancer patients who had single cancer only. The results showed that previous malignancy along with main non-radiation factors is statistically significant carcinogenic risk factor among nuclear workers exposed to protracted occupational radiation. Doi: 10.28991/SciMedJ-2021-0301-2 Full Text: PDF
Cultural Heritage and Associations in France: Reflections on a Ground-Breaking Investigation, Twenty Years On
Authors: Bullen Claire , Isnart Cyril , Glevarec Hervé , Saez Guy 
Published: March 2021

This interview was carried out to mark the approaching twentieth anniversary of what has become a seminal text within French heritage studies: Le Patrimoine saisi par les associations (Heritage in the Hands of Associations). Ahead of its time, this work by the French sociologists Hervé Glevarec and Guy Saez shed light on a number of important yet little-studied dynamics relating to the interactions between the field of heritage and associations in France. Today many of the aspects they outlined (the role of the associative sector in expanding the notion of heritage in France; opening up of the category of heritage to include customs, rituals, know-how and memories; the interest in following the biographical trajectories of heritage actors) have become a common part of heritage making and a focus of heritage studies around the world. Somewhat surprisingly, there has been very little intellectual follow-up of Glevarec and Saez’ pioneering work. As well as detailing the social context that led to the study and underlining some of the key findings, in the interview Glévarec and Saez point to some significant evolutions in political, intellectual and moral paradigms affecting contemporary cultural heritage production. Accordingly, the interview demonstrates the historical value of ethnographic and sociological studies which, when compared with more recent research, can help chart the extent of transformations of a social field over time.
Anti‐Diabetic Effects of Different Phenolic‐Rich Fractions from Rhus Chinensis Mill. Fruits in vitro
Authors: Liu Xiaojing , Fu Yishan , Ma Qian , Yi Junjie , Cai Shengbao 
Published: March 2021

This study investigated the inhibitory effects of the Ethanol Extract (EE), Free Phenolic (TF), Esterified Phenolic (TE) and Insoluble‐bound Phenolic (TI) from Rhus chinensis Mill. fruits on α‐glucosidase, Dipeptidyl Peptidase‐4 (DPP‐IV), and the formation of Advanced Glycation End (AGE) products. Results showed that the TF had the strongest inhibition against α‐glucosidase and DPP‐IV with IC50 of 0.56 ± 0.04 and 66.08 ± 1.36 μg/mL, respectively (p < 0.05). TI exhibited the strongest inhibitory effect on the formation of AGEs with IC50 of 0.43 ± 0.03 mg/mL (p < 0.05). Two major compounds (myricetin‐3‐O‐rhamnoside and quercetin‐3‐O‐rhamnoside) showed additive or synergistic effects on α‐glucosidase inhibition, while displayed antagonistic effect on DPP‐IV inhibition. Correlation analysis indicated that myricetin‐3‐O‐(6″‐galloyl) glycoside and myricetin O‐gallate contributed significantly on α‐glucosidase inhibition, while di‐O‐galloyl‐glucoside and its isomer may contribute remarkably toward DPP‐IV inhibition. Protocatechuic acid and myricetin‐3‐O‐rhamnoside showed a positive correlation with the suppression of AGEs formation. Those results may provide some scientific information for exploring R. chinensis fruits as nutraceuticals and/or functional foods to prevent or improve diabetes.
ЕКСПЕРИМЕНТАЛЬНЕ ДОСЛІДЖЕННЯ ЯКОСТІ ПОВІТРЯ ТА ПОВІТРООБМІНУ В ЗАКЛАДАХ ОСВІТИ ТА ЖИТЛОВИХ БУДІВЛЯХ
Authors: Дешко В. І. , Білоус І. Ю. , Виноградов-Салтиков В. О. , Суходуб І. О. , Яценко О. І. 
Published: March 2021

Apply integrated approaches for the air exchange rate determination based on CO 2 concentration in educational and residential buildings of Ukraine. Methods. Taking into account variability of building's visitors and occupants operational and behavioral features experimental and calculated determination of the air exchange rate are considered. Results. Recommendations for providing comfort conditions in terms of air quality in the considered objects premises, recommendations on the premises operating conditions, ventilation schedule. Scientific novelty. The comprehensive approach to in-depth analysis of energy consumption has been developed, procedures for assessing the air quality and the level of air exchange in buildings have been improved taking into account the variability of operating conditions. The practical significance. Experimental studies of changes in CO 2 concentration were conducted in three schools, in higher education institution and in residential building. The research results allowed to establish the actual level of CO 2 concentration and air change rate under different operational and behavioral conditions in buildings during working hours, subject to comfortable conditions, and during non-use hours. The research results also help to determine the dynamics of changes in the studied factor over time under the building performance indicators influence. The obtained results allow to provide recommendations on ensuring the quality of indoor air exchange and on providing comfort working, studying and living conditions. The use of experimental and calculated air exchange rate values for various premises would allow to avoid in mathematical modeling the overestimation of the level of buildings energy consumption, which arises when standard air change rate values is using. So the obtained results allow to approximate more accurately the mathematical modeling results of buildings energy efficiency to the actual conditions and help to choose the optimal schedule for the building engineering networks managing considering comfort conditions with intermittent operation.
ВИВЧЕННЯ ПРОЦЕСУ ОДНОВІСНОГО РОЗТЯГУ ТРИКОТАЖУ ПЕРЕПЛЕТЕННЯ ЛАСТИК РІЗНИХ РАПОРТІВ
Authors: Єліна Т. В. , Пухова А. В. , Романюк В. П. , Галавська Л. Є. 
Published: March 2021

Study of the process of deformation of rib knits, which occurs due to the application of tensile forces in the course direction. Methodology. During the study, methods of theoretical analysis, a camera, a stretching frame, Microsoft Excel software and Autodesk AutoCAD were used. Findings. For producing rib knit samples, a 10th class flat-bed knitting machine PVRK was used. Samples of knitwear were made with repeatable unit patterns of 1x1, 2x2, 3x3, 4x4, 5x5 and 6x6 from bamboo yarn of linear density 29x2 tex, woolen yarn 32x2 tex, half-woolen yarn 31x2 tex and Polyacrylonitrile yarn 32x2 tex. To carry out uniaxial stretching of knitted fabric samples along the line of stitch rows, a stretching frame was used. After fixing the opposite ends of the sample on the needle set of the frame holders, the distance between them gradually increased with an interval of 20 mm. At each stage of stretching, the samples were photographed together with a calibration ruler. Sample photos imported into Autodesk AutoCAD software. After calibration, for each state of stretching of the sample, such characteristics were determined as: the average value of the width of the repeatable unit pattern, the average value of the width of the convex part of the pattern, as well as the visible section of its concave part. The study showed that at the first stages of stretching, there is a mutual displacement of the sections of the pattern, belonging to different layers of knitwear and a decrease in the twisting of the sections of the smooth surface. Further application of the tensile force leads to a more uniform deformation of the ivestigated structural parts of the pattern. Scientific novelty. The change in the geometric characteristics of rib knits with various repeatable units patterns made from various types of raw materials is experimentally determined. Practical value. The characteristics of knitwear, obtained in the course of the study, were used to form a database necessary for the construction of three-dimensional models of rib knits with bamboo, woolen, semi-woolen, and polyacrylonitrile yarns.
Improvement of Methods of Standardisation of Medicinal Products Made from Veratrum Lobelianum Rhizomes with Roots
Authors: Antonova N. P. , Morgunov I. M. , Prokhvatilova S. S. , Shefer E. P. , Evdokimova O. V. , Beketova A. V. , Lyakina M. N. 
Published: March 2021

Abstract. Identification of hellebore (Veratrum Lobelianum Bernh.) herbal substance, as well as hellebore-based herbal preparation and herbal medicinal product by the same group of biologically active substances using the same test method is in line with the so-called “consistent standardisation” principle.The aim of the study was to develop a harmonised approach to identification of steroidal alkaloids in hellebore products (hellebore water, hellebore tincture) and hellebore herbal substance (hellebore rhizomes with roots).Materials and methods: samples of hellebore water, hellebore tincture, and hellebore rhizomes with roots were analysed by high-performance thin-layer chromatography (HPTLC) using an HPTLC plate.Results: the authors developed a harmonised identification procedure for products made from hellebore rhizomes with roots (herbal substance, herbal preparation, and herbal medicinal product) based on HPTLC detection of steroidal alkaloids. The results of the study will be used to prepare amendments to the Identification part of monograph FS.2.5.0104.18 “Hellebore rhizomes with roots”. The developed test procedure is proposed for inclusion into draft monographs “Hellebore rhizomes with roots, tincture” and “Hellebore rhizomes with roots, tincture, solution for external use”.Conclusions: the developed test procedure can be used as an identification test for a range of products from the hellebore herbal substance to hellebore-based herbal medicinal products, which is based on the detection of the same group of biologically active substances.
REALIZATION OF MULTI-STAGE MODEL OF BABBIT FATIGUE DAMAGES AND BABBIT ANTI-FRICTION LAYERS
Authors: Zernin Mikhail , Rybkin Nikolay , Emel'yanov Ivan , Matyuhin Aleksey 
Published: March 2021

The research purpose is to realize a multi-stage model developed by the authors to show fatigue failures accumulation and failures of anti-friction materials and layers in slider bearings.
The model describes: a scattered accumulation of micro-cracks, formation and development of a micro-crack system up to a limiting state of an object. There are solved some problems. The problem of model parameter identification on the basis of the analysis of babbit sample tests is solved with the use of the simplest optimization method – a method of a deformable polyhedron.
At that there are used principles of the least-squares method. A new result is four model parameters obtained finally. A computation problem of anti-friction babbit layer life required the development of a new software product. Software testing is carried out as a comparison of bearing-sample tested for fatigue and calculated life of these samples. The calculated and experimental lives are consistent. It confirms model working capacity.
Harga Diri dan Dukungan Sosial dengan Kesejahteraan Psikologis pada Guru
Authors: Rosita Eva 
Published: March 2021

Tujuan-dalam penelitian yakni agar dapat mengetahui adanya kaitan atara harga-diri dan dukungan social dengan-kesejahteraan-psikologis,pada pengajar guru yang berada dimadura. Variabel yang diteliti pada penelitian yaitu kesejahteraan psikologis sebagai variabel dependen setelah itu harga diri dan-dukungan-sosial-sebagai variable independent, penelitian-ini-menggunakan-metode-kuantitatif. Subjek-dalam-penelitian-ini-adalah guru memiliki double jobs dan bertempat tinggal dimadura dengan subyek sebanyak 140 orang. Instrumen penelitian ini ialah skala kesejahteraan psikologi, skala harga diri serta skala, dukungan sosial yang disusun menggunakan skala likert. Metode analisis menggunakan analisis regresi. Hasil-analisis-menunjukkan terdapat hubungan harga diri dan dukungan sosial dengan kesejahteraan psikologis pada guru dapat diterima Hal ini dilihat dari taraf f hitung sebesar 33.288 pada dan taraf signifikansi 0,000 sehingga hipotesa diteriam, terdapat-hubungan-positif-harga-diri dengan kesejahteraan psikologis, Hal ini dilihat dari taraf thitung sebesar t = 3.718 pada p = 0,000-(p < 0,01) yang berarti diterima, dukungan social tidak mempengaruhi kesejahteraan psikologis pada guru dimadura. Hal ini dilihat dari taraf thitung sebesar t = 1.815 pada p = 0,072 (p < 0,01) yang berarti ditolak. Hasil penelitian diatas disimpukan bahwa kesejahteraan psikogis dapat diterima karna harga diri dan dukungan sosial, namun dukungan sosial tidak mempengaruhi kesejahteraan psikologis pada guru-guru yang ada di Madura.
Perilaku bullyinng pada remaja: Bagaimana peranan harga diri dan iklim sekolah
Authors: Suhadianto Suhadianto , Syuhud Mohammad Haris , Pratikto Herlan 
Published: March 2021

Abstrak. Perilaku bullying yang banyak terjadi pada remaja perlu mendapatkan perhatian karena memiliki dampak psikologis yang serius bagi pelaku dan korban. Tujuan penelitian ini untuk menguji hubungan antara harga diri, iklim sekolah dan perilaku bullying pada remaja. Partisipan penelitian berjumlah 56 remaja dengan rentang usia 14 sampai 19 tahun, diambil secara purposive. Data penelitian diperoleh melalui skala harga diri (?=0.857), skala iklim sekolah (?=0.898), dan skala perilaku bullying (?=0.807) yang disusun sendiri oleh peneliti. Hasil analisis data menggunakan korelasi Spearman’s Rho menunjukkan tidak ada hubungan negatif yang signifikan antara harga diri dengan perilaku bullying dan antara iklim sekolah dengan perilaku bullying. Implikasi dan keterbatasan penelitian akan dibahas. Abstract . Bullying behavior that often occurs in adolescents needs attention because it can have a negative impact on academic success and social relationships. The purpose of this study was to examine the relationship between self-esteem, school climate, and bullying behavior in adolescents. The study participants were 56 adolescents ranging in age from 14 to 19 years, taken purposively. The research data were obtained through the self-esteem scale (? = 0.857), the school climate scale (? = 0.898), and the bullying behavior scale (? = 0.807), the three scales were compiled by the researchers themselves. The results of data analysis using the Spearman's Rho correlation showed that there was no significant negative relationship between self-esteem and bullying behavior and between school climate and bullying behavior. The implications and limitations of the study will be discussed.Kata kunci: harga diri, iklim sekolah, perilaku bullying
СТРУКТУРНО-КОМПОЗИЦІЙНІ ПАРАМЕТРИ ТА СТИЛЬОВІ ОЗНАКИ ЖАНРУ ЛІТАНІЇ В МУЗИЧНО-ІСТОРИЧНОМУ КОНТЕКСТІ
Authors: Matushchak Tetiana Volodymyrivna 
Published: March 2021

Мета дослідження – зібрати відомості про жанр літанії, виявити ключові ознаки жанру, дослідити жанр літанії у творчості компози- торів різних національних шкіл, здійснити комплексний аналіз жанру із виявленням усіх закономірностей структури і за наявності текстової складової частини. Методологія дослідження об’єднує такі підходи, як компаративний метод, історичний метод для лінійного розгляду пробле- ми трансформації жанру літанії, метод системного аналізу, семіоло- гічний, герменевтичний. Наукова новизна полягає в систематизації на- явних відомостей про жанр літанії та виявленні основних характерних рис жанру в композиціях світського та церковного характеру, створенні цілісної картини розвитку та модифікацій жанру в хронологічному роз- гортанні у творчості композиторів на основі знайдених зразків. Висно- вки. На основі виконаного аналізу наявних теоретичних відомостей про жанр та вивчення композиційних зразків літаній ми дійшли висновків, що даний жанр є досить рухливим відносно структурних характерис- тик, що зумовлюється його значною історією розвитку, яка об’єднує сімнадцять століть. У перші століття існування жанру в літанії вже була закладена ця двоякість: церковне застосування літанії як молитви у храмі та вихід жанру із храму – хресні ходи під час перенесення мощей чи інших процесій. Із часом ця багатозначність тільки посилюється і тепер літанією можна назвати: молитву у храмі (включена у службу молитва у притворі храму як додаткова частина до служби), хресні ходи від од- ного храму в інший, композиції духовного характеру, які застосовуються в світському варіанті зі збереженням основних структурних закономір- ностей, композиції світського характеру, де відсутні майже всі харак- терні риси притаманні жанру. У різний історичний період існувала своя характерна літанія зі своєю структурою і особливостями, що особли- во значно виявилось у літаніях Ф. Пуленка, С. Монюшка, Дж. Кейджа, Ж. Алена. Літанія, як жанр церковної музики, зустрічається і у право- славній, і в католицькій традиціях. У православній традиції даний жанр практично не виходить за межі храму, в католицькій – отримує розви- ток і в канонічній, і в світській сферах.