bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mediating Effects of Coping Strategies on the Relationship Between Mental Health and Quality of Life Among Indonesian Female Migrant Workers in Taiwan
Authors: Pangaribuan Santa Maria , Lin Yen-Kuang , Lin Mei-Feng , Chang Hsiu-Ju 
Published: November 2021

Introduction: Mental health is a major concern among migrant workers worldwide. More than 200,846 female migrant workers in Taiwan are from Indonesia. The study’s purpose was to investigate mediating effects of coping strategies on the relationship between mental health problems and the quality of life (QoL). Method: This cross-sectional study was conducted in Taiwan. In total, 500 Indonesian female migrant workers completed four questionnaires. A mediation test was conducted to estimate direct and indirect effects. Results: Coping strategies, namely substance use, behavioral disengagement, denial, and religious dedication, partially mediated the relationship between mental health problems (depression, anxiety, and stress) and QoL among Indonesian female migrant workers in Taiwan. Discussion: Health promotion programs should be developed for Indonesian female migrant workers in Taiwan to help them detect and overcome their mental health problems. Interventions that facilitate effective coping strategies should be administered to improve their QoL.
A CBCT Study for Anatomic Variations of Osteomeatal complex in Patients With Cleft Lip and Palate
Authors: Göksel Sevde , Özcan İlknur 
Published: November 2021

Objective To evaluate the anatomy and variations of osteomeatal complex (OMC) by comparing patients with nonsyndromic cleft lip and palate (CLP) and control group. Design This case-control study was retrospectively analyzed using cone-beam computed tomography data. Setting Istanbul University Faculty of Dentistry Department of Dentomaxillofacial Radiology. Patients The study was conducted with 100 patients (44 females, 56 males) with CLP and 100 patients in the control group, which matched gender and age (with a maximum difference of 3 years). Variables OMC variations are grouped as follows: ethmoidal, conchal, uncinate process, and septal variations. Then, we evaluated the presence of these OMC variations and compared them between the two groups. Statistical analysis The McNemar's test was used to determine any significant differences between the groups for all indices at the 95% confidence level. Results The most common anatomic variation in this study was Agger nasi cell (97%) and concha bullosa (97%) in the patients with CLP, while Agger nasi cell was the most common variation (99%) in the controls. Moreover, the atelectatic uncinate process was the least observed variation in both groups (1%). The incidences of paradoxical concha (58%;42%), bifid concha (29%;11%), deviated nasal septum (92%;80%) were significantly higher in the CLP group ( p < 0.05). Conclusions The statistically significant results found when comparing OMC anatomy between the two groups reveal the importance of three-dimensional evaluation before functional endoscopic sinus surgery in patients with CLP.
Presentation and Management of Atypical Orofacial Clefts: A Single-Institution Experience for 13 Year Period
Authors: James O , Sabo VY , Adamson OO , Otoghile B , Adekunle AA , Adeyemo W.L , Ladeinde AL , Ogunlewe MO 
Published: November 2021

This study reviews the craniofacial clefts that presented at a Nigerian tertiary health facility, highlighting our experience with the pattern of presentation and surgical care of these patients. A retrospective review of the smile train database and medical records of all individuals who had been diagnosed with any of the Tessier craniofacial clefts and managed between 1st January 2007 and 31st December 2020 was done. The data were presented as numbers and percentages of cases. The cleft clinic of a tertiary health facility and a major cleft referral center in South-West Nigeria. Forty-five patients with craniofacial clefts were managed over the study period. 15.6% had associated syndromes, 2.2% had a family history of similar craniofacial cleft and 11% had a history of a possible teratogen. There were 21 (46.7%) middle clefts, 14(31.1%) lateral clefts and 10(22.2%) oblique clefts. The most common type of cleft was Tessier 0 while the Tessier 6 was the least common type. The median age at surgery was 10 months for male and 5months for female subjects, 15.3% complication rate was found in this study. Four patients had revision surgeries to correct residual deformities in this study. The diverse presentations and occurrence of the rare craniofacial clefts present complex aesthetic and functional problems that require individualized often multidisciplinary care. The execution of a properly planned treatment will reduce complications and the need for revision surgeries.
Nonsedated Magnetic Resonance Imaging for Visualization of the Velopharynx in the Pediatric Population
Authors: Kotlarek Katelyn J. , Sitzman Thomas J. , Williams Jessica L. , Perry Jamie L. 
Published: November 2021

Background Non-sedated MRI is gaining traction in clinical settings for visualization of the velopharynx in children with velopharyngeal insufficiency. However, the behavioral adaptation and training aspects that are essential for successful pediatric MRI have received limited attention. Solution We outline a program of behavioral modifications combined with patient education and provider training that has led to high success rates for non-sedated velopharyngeal MRI in children.
A Comprehensive Investigation on Potential Risk Factors for NSCL/P in a Rural District of Hebei Province, China
Authors: Chai Congna , Cheng Lei , Jiao Jianjun , Dang Juan , Jin Shubin 
Published: November 2021

Non syndromic cleft lip with or without palate (NSCL/P), one of the most common birth defects, is closely related to various risk factors. However, information regarding risk factors for NSCL/P in rural districts in China is very limited thus far. The objective of this study was designed to identify the potential risk factors for NSCL/P in rural districts. A comprehensive retrospective investigation including 435 NSCL/P patients and 402 healthy children was carried out in Hebei Province, China. Multiple logistic regression analysis and transmission disequilibrium test (TDT) were respectively used to identify non-genetic and genetic risk factors for NSCL/P, and then PLINK was used to explore the relationship between non-genetic and genetic risk factors. The results showed that maternal periconceptional exposure to pesticides and herbicides, as well as low parental education level were involved in the increased risk of NSCL/P, whereas maternal folic acid and multivitamin supplementation use during preconception period were associated with the reduced risk of NSCL/P. TDT analysis identified 2 single nucleotide polymorphisms (SNPs) (rs7078160 and rs4752028) in VAX1 and one SNP (rs17563) in BMP4 as the genetic risk factors for NSCL/P. Further analysis showed that the genetic risk factors were closely related with the negative non-genetic risk factors. Our study identified the potential risk factors for NSCL/P in rural districts, thus providing a theoretical basis for the prevention of NSCL/P occurrence.
Prevalence and predictors of hypertension among adults in Mbarara City, Western Uganda
Authors: Batte Anthony , Gyagenda Joseph Ogavu , Otwombe Kennedy , Muhindo Rose , Bagasha Peace , Kiggundu Daniel , Aujo Judith Caroline , Atuhe David Martin , Kansiime Grace , Hussein Reham , Namuyimbwa Lydia , Mukasa Sandra Luyima , Kabuye Amina , Mukasa Joseph , Sekasanvu Emmanuel , Kalyesubula Robert 
Published: November 2021

Objective The study aim was to evaluate the prevalence and predictors of hypertension among an urban adult population in Mbarara city, Western Uganda. Methods We evaluated blood pressure measurements, social demographic and clinical parameters of adults living in Mbarara city, Uganda. These parameters were extracted from medical records of adults who participated in the Uganda World Kidney Day 2020 health screening activities. A total of 302 adults were evaluated for hypertension using the American College of Cardiology/American Heart Association 2017 (blood pressure threshold 130/80 mmHg) and International Society of Hypertension 2020 guidelines (threshold 140/90 mmHg). Results The mean age of the participants was 42.5 years (standard deviation: 15.1) and majority were male 195/302 (64.6%). Using American College of Cardiology/American Heart Association 2017 guidelines, 156/302 (51.7%) adults were newly diagnosed with hypertension compared to 68/302 (22.5%) newly diagnosed with hypertension using International Society of Hypertension 2020 guidelines. Only 23/302 (7.6%) were on treatment. Based on American College of Cardiology/American Heart Association 2017 guidelines, age ≥40 years and overweight/obesity were statistically significant predictors of hypertension (p < 0.05 for all) at multivariate analysis. Using the International Society of Hypertension 2020 guidelines, age ≥40 years predicted hypertension. Discussion The prevalence of hypertension is high among this urban adult population irrespective of the guidelines used, highlighting the need for hypertension prevention interventions.
Lavender Aromatherapy to Reduce Anxiety During Intrauterine Insemination: A Randomized Controlled Trial
Authors: Jones Tiffanny , Purdy MacKenzie , Stewart Elizabeth A. , Cutshall Susanne M. , Hathcock Matthew A. , Mahapatra Saswati , Bauer Brent A. , Ainsworth Alessandra J. 
Published: November 2021

Background Infertility is a global public health issue. Therapies such as intrauterine insemination (IUI) are effective but may be associated with considerable anxiety. Preliminary data suggest that decreasing this anxiety might lead to improved outcomes. Objective To determine whether lavender aromatherapy (LA) reduces anxiety during an IUI procedure. Methods A randomized controlled trial of women undergoing IUI at a hospital-based fertility clinic. The intervention and comparison were the use of LA vs water. Measurements were the change in anxiety level during an IUI procedure, with secondary assessment of pain scores, patient satisfaction, and pregnancy rates. Results In total, 67 women were screened, and 62 women randomly assigned to either placebo (n = 31) or LA (n = 31). No differences were observed in baseline demographic characteristics or visual analog scores for anxiety before IUI (mean [95% CI], 33.9 [25.2 to 45.6] mm vs 41.0 [33.0 to 49.0] mm) in the LA and placebo groups. However, a statistically significant change in anxiety was observed after LA inhalation during the procedure (mean [95% CI], −11.2 [−19.1 to −3.2]) compared with placebo (mean [95% CI], 1.3 [−5.6 to 8.2]; P = .02). No significant difference was observed in pain during IUI in the LA group vs placebo group. Patient satisfaction was high, with 93% of respondents in the LA group satisfied with the aromatherapy during their procedure. Additionally, 76% of participants who received placebo reported that they would prefer to use LA during their IUI. No statistically significant difference was detected in pregnancy rates between the 2 groups: 19.4% with LA vs 9.7% with placebo ( P = .47). Conclusion LA reduced anxiety and was preferred by women during IUI fertility treatments.
Is there difference and correlation between medial and lateral tibial plateau coronal obliquity in native knee? A radiographic study
Authors: Leung Thomas Ka Chun , Lau Will Wai Hong , Fung Wing Chiu , Chan Vincent Wai Kwan , Cheung Amy , Cheung Man Hong , Fu Henry , Yan Chun Hoi , Chan Ping Keung , Chiu Kwong Yuen 
Published: November 2021

Background/Purpose Knee joint line is commonly defined as a tangent to medial and lateral tibial plateaus in various radiographic measurements. We aim to investigate radiographic differences between medial and lateral knee joint line coronal obliquity. It has significant implication on radiographic analysis following unicompartmental knee arthroplasty. Methods We analysed the knee radiographs of 48 young patients (mean age 25.1 + /-5.6 years) with 50 anterior cruciate ligament-deficient knees. Medial and lateral tibial plateau coronal obliquity were defined as angles between femoral knee joint line and the tangent to articular surface of each tibial plateau. Mediolateral differences and linear correlation were analysed. Results Significant difference was found between medial (mean = -1.5, SD = 2.4 degrees) and lateral obliquity (mean =  + 0.6, SD = 3.0 degrees) ( p < 0.001). The mean mediolateral difference was 3.1 degrees (SD = 2.8, range 0–11.8 degrees), without significant correlation (r = 0.085, p = 0.56). Conclusion Mediolateral differences exist in knee joint line obliquity. Each compartment should be considered separately when measuring knee joint line obliquity.
Joint awareness after unicompartmental and total knee arthroplasty: Which feels more natural?
Authors: Güngör Reşit Harun , Bayrak Gökhan , Şavkın Raziye , Büker Nihal 
Published: November 2021

Background/Purpose The purpose of this study was to compare the joint awareness and knee function after unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) for the management of isolated medial compartment osteoarthritis. Methods Patients who underwent UKA or TKA at our institution for isolated medial compartment osteoarthritis from 2015 to 2020 with a minimum follow-up of 1 year were screened. 116 eligible patients were invited and 94 volunteer patients participated. All patients were evaluated with The Forgotten Joint Score-12 and Lysholm Knee Scale. Results Average follow-up period was 29.13±15.48 months for UKA and 31.66±2.91 months for TKA groups ( p=0.292). FJS-12 of the UKA group was significantly higher than that of the TKA group (79.74±15.06 and 63.25±19.86, respectively; p=0.024). The Lysholm Knee Scale score was also significantly higher in the UKA group compared with the TKA group (92.94±8.74 and 78.34±14.99, respectively; p = 0.002). Conclusion Our findings suggest that patients who underwent UKA were less aware of their artificial joints and had better knee function compared to patients who underwent TKA for medial osteoarthritis of the knee.
Hiking-related orthopaedic injuries: Another epidemic during the COVID-19 pandemic
Authors: Chu Wing Yiu Claudia , Chong Yau Chun , Mok Wing Yuk 
Published: November 2021

Introduction Coronavirus disease 2019 (COVID-19) had spread to over 200 countries and regions across the world since early 2020. Travel bans had been implemented in Hong Kong to control the spread of virus. Despite the burden to the healthcare system brought by COVID-19, there was also an increase in number of hiking-related injuries requiring inpatient care. The aim of this study is to report the incidence of hiking-related injuries admitted to the orthopaedic wards during the COVID-19 pandemic and comparison with statistics from the past years. Methods Data was retrieved from the admission books of the orthopaedic wards and Electronic Patient Records. The number of admissions, patients’ demographics and details of hospitalisation were compared between February to May 2020 (COVID-19 study period) and 2019. Secondary analysis was performed on admissions for tibia and/or fibula fractures with or without operation during the study period and compared with the past five years. Results 48 patients were admitted due to hiking-related conditions during the COVID-19 study period, which was 2.4 times more than 2019. 23 patients suffered from tibia and/or fibula fractures and was higher than the past five years (average 5.8, p = 0.0001). Among patients operated for tibia and/or fibula fractures, the percentage of hiking-related injuries was 41.9% in 2020 and 6.9% in the past five years (p = 0.0002). Conclusions An increase in incidence of hiking-related orthopaedic injuries was observed during the COVID-19 pandemic. Healthcare workers, public health experts and government officials should work together to raise awareness on safety in hiking for effective prevention of injury.
How I treat frontline transplantation-eligible multiple myeloma
Authors: Perrot Aurore 
Published: November 2021

AbstractHigh-dose melphalan supported by autologous transplantation has been the standard of care for eligible patients with newly diagnosed multiple myeloma (MM) for &gt;25 years. Several randomized clinical trials have recently reaffirmed the strong position of transplantation in the era of proteasome inhibitors and immunomodulatory drugs combinations, demonstrating a significant reduction of progression or death in comparison with strategies without transplantation. Immunotherapy is currently changing the paradigm of MM management, and daratumumab is the first-in-class human monoclonal antibody targeting CD38 approved in the setting of newly diagnosed MM. Quadruplets have become the new standard in transplantation programs, but outcomes remain heterogeneous, with various response depth and duration. The development of sensitive and specific tools for disease prognostication allows the consideration of strategies adaptive to dynamic risk. This review discusses the different options available for the treatment of transplantation-eligible patients with MM in frontline setting.
PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in human and murine acute myeloid leukemia
Authors: Goswami Swagata , Mani Rajeswaran , Nunes Jessica , Chiang Chi-Ling , Zapolnik Kevan , Hu Eileen , Frissora Frank , Mo Xiaokui , Walker Logan A. , Yan Pearlly , Bundschuh Ralf , Beaver Larry , Devine Raymond , Tsai Yo-Ting , Ventura Ann , Xie Zhiliang , Chen Min , Lapalombella Rosa , Walker Alison , Mims Alice , Larkin Karilyn , Grieselhuber Nicole , Bennett Chad , Phelps Mitch , Hertlein Erin , Behbehani Gregory , Vasu Sumithira , Byrd John C. , Muthusamy Natarajan 
Published: November 2021

Abstract
Dysregulated cellular differentiation is a hallmark of acute leukemogenesis. Phosphatases are widely suppressed in cancers but have not been traditionally associated with differentiation. In this study, we found that the silencing of protein phosphatase 2A (PP2A) directly blocks differentiation in acute myeloid leukemia (AML). Gene expression and mass cytometric profiling revealed that PP2A activation modulates cell cycle and transcriptional regulators that program terminal myeloid differentiation. Using a novel pharmacological agent, OSU-2S, in parallel with genetic approaches, we discovered that PP2A enforced c-Myc and p21 dependent terminal differentiation, proliferation arrest, and apoptosis in AML. Finally, we demonstrated that PP2A activation decreased leukemia-initiating stem cells, increased leukemic blast maturation, and improved overall survival in murine Tet2−/−Flt3ITD/WT and human cell-line derived xenograft AML models in vivo. Our findings identify the PP2A/c-Myc/p21 axis as a critical regulator of the differentiation/proliferation switch in AML that can be therapeutically targeted in malignancies with dysregulated maturation fate.
Venetoclax plus dose-adjusted R-EPOCH for Richter syndrome
Authors: Davids Matthew S. , Rogers Kerry A. , Tyekucheva Svitlana , Wang Zixu , Pazienza Samantha , Renner Sarah K. , Montegaard Josie , Ihuoma Udochukwu , Lehmberg Timothy Z. , Parry Erin M. , Wu Catherine J. , Jacobson Caron A. , Fisher David C. , Thompson Philip A. , Brown Jennifer R. 
Published: November 2021

Abstract
Richter syndrome (RS) of chronic lymphocytic leukemia (CLL) is typically chemoresistant, with a poor prognosis. We hypothesized that the oral Bcl-2 inhibitor venetoclax could sensitize RS to chemoimmunotherapy and improve outcomes. We conducted a single-arm, investigator-sponsored, phase 2 trial of venetoclax plus dose-adjusted rituximab, etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (VR-EPOCH) to determine the rate of complete response (CR). Patients received R-EPOCH for 1 cycle, then after count recovery, accelerated daily venetoclax ramp-up to 400 mg, then VR-EPOCH for up to 5 more 21-day cycles. Responders received venetoclax maintenance or cellular therapy off-study. Twenty-six patients were treated, and 13 of 26 (50%) achieved CR, with 11 achieving undetectable bone marrow minimal residual disease for CLL. Three additional patients achieved partial response (overall response rate, 62%). Median progression-free survival was 10.1 months, and median overall survival was 19.6 months. Hematologic toxicity included grade ≥3 neutropenia (65%) and thrombocytopenia (50%), with febrile neutropenia in 38%. No patients experienced tumor lysis syndrome with daily venetoclax ramp-up. VR-EPOCH is active in RS, with deeper, more durable responses than historical regimens. Toxicities from intensive chemoimmunotherapy and venetoclax were observed. Our data suggest that studies comparing venetoclax with chemoimmunotherapy to chemoimmunotherapy alone are warranted. This trial was registered at www.clinicaltrials.gov as #NCT03054896.
Drug–target interaction prediction using unifying of graph regularized nuclear norm with bilinear factorization
Authors: Sorkhi Ali Ghanbari , Abbasi Zahra , Mobarakeh Majid Iranpour , Pirgazi Jamshid 
Published: November 2021

Abstract
Background
Wet-lab experiments for identification of interactions between drugs and target proteins are time-consuming, costly and labor-intensive. The use of computational prediction of drug–target interactions (DTIs), which is one of the significant points in drug discovery, has been considered by many researchers in recent years. It also reduces the search space of interactions by proposing potential interaction candidates.

Results
In this paper, a new approach based on unifying matrix factorization and nuclear norm minimization is proposed to find a low-rank interaction. In this combined method, to solve the low-rank matrix approximation, the terms in the DTI problem are used in such a way that the nuclear norm regularized problem is optimized by a bilinear factorization based on Rank-Restricted Soft Singular Value Decomposition (RRSSVD). In the proposed method, adjacencies between drugs and targets are encoded by graphs. Drug–target interaction, drug-drug similarity, target-target, and combination of similarities have also been used as input.

Conclusions
The proposed method is evaluated on four benchmark datasets known as Enzymes (E), Ion channels (ICs), G protein-coupled receptors (GPCRs) and nuclear receptors (NRs) based on AUC, AUPR, and time measure. The results show an improvement in the performance of the proposed method compared to the state-of-the-art techniques.
Prenatal diagnosis of auriculocondylar syndrome with a novel missense variant of GNAI3: a case report
Authors: Liu Xiaoliang , Sun Wei , Wang Jun , Chu Guoming , He Rong , Zhang Bijun , Zhao Yanyan 
Published: November 2021

Abstract
Background
Auriculocondylar syndrome (ACS) is a rare disorder characterized by micrognathia, mandibular condyle hypoplasia, and auricular abnormalities. Only 6 pathogenic variants of GNAI3 have been identified associated with ACS so far. Here, we report a case of prenatal genetic diagnosis of ACS carrying a novel GNAI3 variant.

Case presentation
A woman with 30 weeks of gestation was referred to genetic counseling for polyhydramnios and fetal craniofacial anomaly. Severe micrognathia and mandibular hypoplasia were identified on ultrasonography. The mandibular length was 2.4 cm, which was markedly smaller than the 95th percentile. The ears were low-set with no cleft or notching between the lobe and helix. The face was round with prominent cheeks. Whole-exome sequencing identified a novel de novo missense variant of c.140G > A in the GNAI3 gene. This mutation caused an amino acid substitution of p.Ser47Asn in the highly conserved G1 motif, which was predicted to impair the guanine nucleotide-binding function. All ACS cases with GNAI3 mutations were literature reviewed, revealing female-dominated severe cases and right-side-prone deformities.

Conclusion
Severe micrognathia and mandibular hypoplasia accompanied by polyhydramnios are prenatal indicators of ACS. We expanded the mutation spectrum of GNAI3 and summarized clinical features to promote awareness of ACS.