bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penerapan Metode Eksperimen Untuk Meningkatkan Aktivitas Siswa Pada Pembelajaran IPA Kelas V SD Negeri Ngemplak Kecamatan Windusari Kabupaten Magelang Provinsi Jawa Tengah
Authors: Mundiyah Mundiyah 
Published: September 2021

<p><strong><em> </em></strong></p><p><em>The lack of student interest in learning science subjects due to the wide and varied scope of learning and</em><em> the demands of a complete curriculum with content that must be delivered with a limited time allocation resulted in teachers having difficulty in developing learning methods according to student needs so that student learning outcomes were low. This study aims to increase students' learning motivation on the material for the Environment of Our Friends in class V SD Negeri Ngemplak by using the Experimental method in 2019/2020. The research was carried out in three cycles, with the object of research being 19th grade students, consisting of 10 girls and 9 boys. This research was conducted in three cycles, namely planning, action implementation, and reflection. Data collection techniques used are observation and tests. The application of the Experimental method has been proven to improve student achievement, courage, express opinions, and can learn through direct experience. Can enrich the experience with things that are objective and realistic, Can develop students' scientific attitude and can make learning actual.</em></p>
Peningkatan Hasil Belajar PPKn Melalui Strategi Pembelajaran Aktif Tipe Giving Question and Getting Answer Pada Peserta Didik Kelas V Sekolah Dasar
Authors: Selvinia Riza 
Published: September 2021

<p><em>The purpose of this research was to improve student learning outcomes in PPKn grade V elementary schools with <em> active learning strategy type Giving Question and Getting Answer (GQGA) </em>. The research conducted was a Classroom Action Research (PTK) with three cycles, with each cycle consisting of one meeting. The stages of each cycle are planning, implementing, observing and reflecting. Each meeting is carried out formative test to determine the progress of students. In the first cycle the students who completed after carrying out the formative test were 70% </em>and a class average 70<em>. In the second cycle students who completed after carrying out the formative test were 82,5% dan </em>a class average <em>77. In the third cycle students who completed after carrying out formative test were 100% and a class average 81,75. These results indicate that <em>active learning strategy type giving question and getting answer (GQGA) </em>can improve student learning outcomes, especially grade V PPKn at SD Negeri 04 Serang academic year 2019/2020.</em></p>
Upaya Meningkatan Hasil Belajar Siswa Kelas II Tema 2 Subtema 2 Bermain di Lingkungan Sekolah Melalui Model Pembelajaran Problem Based Learning (PBL) SD Negeri Waru 03
Authors: Nurwantinah Nurwantinah 
Published: September 2021

<p><em>The background of this research is because of the difficulties experienced by the second grade students of SD Negeri Waru 03, Bantarkawung District, Brebes. It is proven by the percentage of student learning in the previous class of 30% of students who have completed. The reason is that they feel bored with the monotonous learning process and do not use varied learning methods.The model in this study uses the Problem Based Learning (PBL) model which consists of 4 stages, namely; planning, implementing actions, observing and reflecting. The subjects of this study were second grade students of SD Negeri Waru 03 Bantarkawung District, Brebes Regency for the 2020-2021 academic year with a total of 13 students, consisting of 10 male students and 3 female students. </em><em>Data collection techniques using interviews, observation, documentation, and written test assessment. The results of this study can be explained as follows: 1) in the application of the Problem Based Learning (PBL) method there is an increase in teacher and student activity in each cycle, this can be proven for teacher activity in the first cycle to reach a percentage of 80% (good), while in the second cycle teacher activity reached a percentage of 100% (very good). Student activity in the first cycle reached a percentage of 69.16% (good), while in the second cycle it reached a percentage of 90.00% (very good) so that in the second cycle it was declared successful because it had reached the KKM</em></p>
Refertilization of Mantle Peridotites from the Central Indian Ridge: Response to a Geodynamic Transition
Authors: Hazra A. , Saha A. , Verencar A. , Satyanarayanan M. , Ganguly S. , Kotha M. 
Published: September 2021

AbstractThe phenomena of reactive percolation of enriched asthenospheric melts and pervasive melt-rock interactions at mid oceanic ridge-rift systems are the principal proponents for mantle refertilization and compositional heterogeneity. This study presents new mineralogical and geochemical data for the abyssal peridotites exposed along the Vema and Vityaz fracture zones of the Central Indian Ridge (CIR) to address factors contributing to the chemical heterogeneity of CIR mantle. Cr-spinel (Cr#: 0.37-0.59) chemistry classifies these rocks as alpine-type peridotites and corroborates a transitional depleted MORB type to enriched, SSZ-related arc-type magma composition. HFSE and REE geochemistry further attests to an enriched intraoceanic forearc mantle affinity. The distinct boninitic signature of these rocks reflected by LREE&gt;MREE&lt;HREE and PGE compositions substantiates refertilization of the CIR mantle harzburgites by boninitic melt percolation concomitant to initiation of oceanic subduction. The mineral chemistry, trace, and PGE signatures of the CIR peridotites envisage (i) replenishment of depleted sub-ridge upper mantle by impregnation of subduction-derived boninitic melts, (ii) tectonic transition from mid oceanic ridge-rift to an embryonic suprasubduction zone, and (iii) initiation of spontaneous intraoceanic subduction along submarine transform faults and fracture zones of slow-spreading CIR owing to the weakness and mechanical instability of older, denser, and negatively buoyant Indian Ocean lithosphere.
Gembala bagi Semua Domba: Memaknai Domba dari Kandang yang Lain dalam Yohanes 10:16 dalam Upaya Merangkul “Sang Liyan”
Authors: Subowo Adhika Tri 
Published: September 2021

AbstractLiving a amid of diversity is not always easy. Sometimes the temptation to be exclusive occurs, to think of ourselves as better and right while others are wrong. As a result the other groups were excluded. Through the effort to interpret the sheep from another cage as contained in John 10:16 we will see that it turns out the Shepherd takes care of all the sheep, including sheep from another cage. To elaborate on this theme, the author will begin by describing the meaning of the shepherd’s metaphor and then raising the reinterpretation of John 10:16 so that the text can be used as a basis to embrace ‘the other’.
AbstrakMenjalani kehidupan ditengah keberagaman tidak selalu mudah. Terkadang godaan untuk menjadi ekslusif terjadi, mengganggap diri kita lebih baik dan benar sedangkan yang lain salah. Alhasil kelompok yang lain tersisih dan bahkan disisihkan. Melalui upaya memaknai domba dari kandang yang lain sebagaimana terdapat dalam Yohanes 10:16 kita akan melihat bahwa ternyata Sang Gembala memelihara semua domba, termasuk domba dari kandang yang lain. Untuk mengelaborasi tema ini, penulis akan memulai dengan menjabarkan makna dari metafor gembala dan kemudian mengangkat reinterpretasi terhadap Yohanes 10:16 sehinggateks dapat dijadikan dasar dalam upaya merangkul ‘sang liyan’.
Mendidik Generasi Z Gereja: Peran Media Sosial di Tengah Bahaya Always-On Attention Deficit Disorder
Authors: Sintauli Susanna Erika 
Published: September 2021

AbstractGeneration Z, presumbably has a very big influence in the world, and also lives in the use of internet. Churches are facing opposite and side by side with this generation need to do shifting-ups with the use of the internet in Christian education, one of which is through social media. However, it cannot be denied that social media also has an impact that needs to be examined, one of which is the danger of Always-On Attenton Deficit Disorder. Information and relations can instantly be transformed into distractions. Therefore, incarnational Christian education can be an important thing to pay attenton to. The incarnational educator will not refuse to enter into the world that Generation Z lives in, but rather create and seek opportunities for face-toface connections but also pay attenton to virtual meeting. Incarnational educators will entersocial media, but do not fall into the dangers of distraction, but rather influence the exemplary life of Jesus who embraces those who are forgo􀆩 en. This is done by presenting relevant faith formation to generation Z. Some important things become guide for educators summarized in several terms, namely Double Content, Share and Comment and Log in-Log out.
AbstrakGenerasi Z yang terbilang memiliki pengaruh sangat besar di dunia, dan juga hidup dalam penggunaan internet. Gereja yang hadir berhadapan dan berdampingan dengan generasi ini perlu melakukan shift ing-up dalam hal penggunaan internet khususnya di bidang pendidikan Kristen, salah satunya adalah melalui media sosial. Namun demikian, tidak dapat dipungkiri bahwa media sosial pun memberi dampak yang perlu diwaspadai, salah satunya adalah bahaya Always-On Attention Deficit Disorder. Informasi dan relasi dapat sekejap bertransformasi menjadi distraksi. Maka dari itu, pendidikan Kristen yang inkarnasional dapat menjadi hal yang penting untuk diperhatikan. Pendidik yang inkarnasional tidak akan menolak masuk ke dalam dunia yang generasi Z hidupi, melainkan mencipta dan mencari kesempatan untuk koneksi tatap muka namun juga memperhatikan perjumpaan virtual. Pendidik yang inkarnasional akan masuk ke media sosial, namun tidak terjerembab ke dalam bahaya distraksi, melainkan memberikan pengaruh teladan hidup Yesus yang merangkul mereka yang terlupakan. Hal ini dilakukan salah satunya dengan menghadirkan pembentukan iman yang relevan kepada generasi Z. Beberapa hal penting yang dapat menjadi pegangan pendidik terangkum dalam beberapa istilah, yakni Double Content, Share and Comment, dan Log in-Log out.
Kebebasan yang Memerdekakan: Sumbangsih Pemikiran Filsafat Anarkisme Epistemologis Paul K. Feyerabend Terhadap Pemahaman Radikalisme Agama
Authors: Lumban Gaol Rumondang 
Published: September 2021

AbstractThis article discusses whether it is true that the biblical texts legitimize religious radicalism. Religious radical movements are present and carry out very violent actions, this is due to religious beliefs that are held as absolute, imposing their beliefs without seeing the beliefs of other parties so as to deny the freedom of others. The purpose of this study is to explore the philosophical thought of Paul Feyerabend’s epistemological anarchism and then see its relevance to the understanding of religious radicalism. The research method used in this paper is a literature study (library). Through this research study, it can be concluded that there is no single truth that can control and regulate human knowledge (Against Method); man must Anything Goes; knowledge cannot be measured by the same standard; and lastly is the concept of individual freedom, individual human beings must be free.
AbstrakArtikel ini membahas tentang benarkah teks-teks Kitab Suci melegitimasi radikalisme agama. Munculnya berbagai gerakan-gerakan radikal agama dan melakukan aksi-aksi yang tergolong sangat kasar disebabkan pemahaman kebenaran yang dianut sebagai kebenaran mutlak, memaksakan kebenarannya tanpa melihat kebenaran pihak lain sehingga mengkungkung kebebasan orang lain. Tujuan penelitian ini adalah mengeksplorasi pemikiran filsafat anarkisme epistimologis Paul Feyerabend kemudian melihat titik relevansinya terhadap pemahaman radikalisme agama. Metode penelitian yang digunakan dalam tulisan ini adalah studi literatur (kepustakaan). Melalui kajian penelitian ini dapat disimpulkan bahwa tidak ada kebenaran yang tunggal yang dapat menguasai dan mengatur pengetahuan manusia (Against Method); manusia harus Anything Goes; pengetahuan tidak bisa diukur dengan standar yang sama; dan terakhir adalah konsep kebebasan individu, manusia individual harus bebas.
Venom of Viperidae: A Perspective of its Antibacterial and Antitumor
Potential
Authors: Teodoro André , Gonçalves Fernando J.M. , Oliveira Helena , Marques Sérgio 
Published: September 2021

:
The emergence of multi-drug resistant bacteria and limitations on cancer treatment represent
two important challenges in modern medicine. Biological compounds have been explored with
a particular focus on venoms. Although they can be lethal or cause considerable damage to humans,
venom is also a source rich in components with high therapeutic potential.

:
Viperidae family is one of the most emblematic venomous snake families and several studies highlighted
the antibacterial and antitumor potential of viper toxins. According to the literature, these
activities are mainly associated to five protein families - svLAAO, Disintegrins, PLA2, SVMPs and
C-type lectins- that act through different mechanisms leading to the inhibition of the growth of bacteria,
as well as, cytotoxic effects and inhibition of metastasis process. In this review, we provide
an overview of the venom toxins produced by species belonging to the Viperidae family, exploring
their roles during the envenoming and their pharmacological properties, in order to demonstrate its
antibacterial and antitumor potential.
Pharmacological Study of A3 Adenosine Receptor agonist (AB Meca) in
Xenograft Lung Cancer Model in Mice through In Silico and In Vivo Approach:
Targeting TNF-α
Authors: Solanki Nilay , Patel Leena , Shah Shaini , Patel Ashish , Patel Swayamprakash , Patel Mehul , Shah Umang 
Published: September 2021

Background:
Lung cancer is the leading cause of mortality in India. Adenosine Receptor
(AR) has emerged as a novel cancer-specific target. A3AR levels are upregulated in various tumor
cells, which may mean that the specific AR may act as a biological marker and target specific ligands
leading to cell growth inhibition.

Aim:
Our aim was to study the efficacy of the adenosine receptor agonist, AB MECA, by in silico
(molecular docking) and in vitro (human cancer cells in xenografted mice) studies.

Method:
Molecular docking on the AB-meca and TNF-α was performed using AutoDock. A549
Human lung cancer 2 ×106 cells per microliter per mouse injected via intrabronchial route. Rat TNF-α
level was assessed by ELISA method.

Results:
AB Meca's predicted binding energy (beng) with TNF-α was 97.13 kcal/mol, and the compatible
docking result of a small molecular inhibitor with TNF-α native ligand beng was 85.76 kcal/mol.
In vivo, a single dose of lung cancer cell A549 is being researched to potentiate tumor development.
Doxorubicin and A3AR agonist therapies have lowered TNF-alpha levels that were associated with in
silico function. The A3AR Agonist showed myeloprotective effects in the groups treated along with
doxorubicin.

Conclusion:
AB MECA’s higher binding energy (beng) with TNF-α mediated reduction of tumor
growth in our lung cancer in vivo model suggested that it may be an effective therapy for lung cancer.
Strategy Analysis of Ynones’ Radical Reactions
Authors: Chen Kaijun , Huang Dayun , Sun Xiangyu 
Published: September 2021

:
This review highlights the multifaceted synthetic applications of ynones in radical reactions.
Substantial progress has been made over the last decade (2010-2020) in the utilization of
ynones. Herein, the chemistry of ynones is divided into three sections based on the classes of critical
mechanistic insights: (1) radical addition and intramolecular cyclization; (2) radical addition
and intermolecular annulation; (3) radical addition and coupling. We hope that this review will
promote future research in this area.
Exploring the Role of Stem Cell Therapy in Treating Neurodegenerative
Diseases: Challenges and Current Perspectives
Authors: Puranik Nidhi , Arukha Ananta Prasad , Yadav Shiv Kumar , Yadav Dhananjay , Jin Jun O. 
Published: September 2021

:
Several human neurological disorders, such as Parkinson’s disease, Alzheimer’s disease,
amyotrophic lateral sclerosis, Huntington’s disease, spinal cord injury, multiple sclerosis, and brain
stroke, are caused by the injury to neurons or glial cells. The recent years have witnessed the successful
generation of neurons and glia cells driving efforts to develop stem-cell-based therapies for
patients to combat a broad spectrum of human neurological diseases. The inadequacy of suitable
cell types for cell replacement therapy in patients suffering from neurological disorders has hampered
the development of this promising therapeutic approach. Attempts are thus being made to reconstruct
viable neurons and glial cells from different stem cells, such as embryonic stem cells,
mesenchymal stem cells, and neural stem cells. Dedicated research to cultivate stem cell-based
brain transplantation therapies has been carried out. We aim at compiling the breakthroughs in the
field of stem cell-based therapy for the treatment of neurodegenerative maladies, emphasizing the
shortcomings faced, victories achieved, and the future prospects of the therapy in clinical settings.
Application of Stem Cell Therapy During the Treatment of HIV/AIDS and
Duchenne Muscular Dystrophy
Authors: Gaobotse Goabaone , Chitena Lorraine , Masisi Keletso , Masisi Kabo , Kwape Tebogo E. 
Published: September 2021

:
Treating diseases such as Muscular dystrophy (MD) and HIV/AIDS pose several challenges
to the rapidly evolving field of regenerative medicine. Previously, stem cell therapy has
been said to affect the clinical courses of HIV/AIDS and MD, but, in practice, eradication or control
of these diseases was not achievable. The introduction of gene editing into stem cell therapy
has stimulated HIV/AIDS and MD cell therapy research studies substantially. Here, we review current
methods of treating HIV/AIDS and MD using stem cell therapy. This review also details the
use of different types of cells and methods in cell therapy and the modeling of new cell-based therapies
to treat Duchenne muscular dystrophy. We speculate that the effective use of stem cell therapy
in conjunction with other treatment therapies , such as steroids and rehabilitation , could improve
livelihood.
Prevalence of CYP2C19 Polymorphisms in Clopidogrel Treated Turkish
Patients: Preliminary Results, 2017
Authors: Susleyici Belgin , Ciftci Cavlan , Yurdakul Selen , Cevik Mehtap , Akdeniz Cansu Selcan , Canbolat Ismail Polat , Deliorman Gokce , Karaalp Atila 
Published: September 2021

Background:
Clopidogrel is one of the most frequently prescribed antiplatelet agents to reduce
the risk of atherosclerotic symptoms. CYP2C19 enzyme is involved in clopidogrel metabolism,
and several genetic variations of CYP2C19gene are able to affect the clinical response of clopidogrel.
Despite the lack of a fully accepted guideline for CYP2C19 pharmacogenetic testing before
clopidogrel treatment by relevant communities, we believe that determination of the variant frequencies
is important to predict the efficiency and possible clopidogrel related risks before the initiation of
treatment on the basis of populations. Our aim was to determine the distribution of gene polymorphisms
affecting the enzyme activity in Turkish cardiac patients prescribed clopidogrel.

Methods:
54 clopidogrel prescribed patients were included in the study. The presence of CYP2C19*2,
*3, *4, *5, *6, *7, *8, *9, *10 and *17 polymorphisms were investigated using a microarray platform.

Results :
No variant allele was detected for *4, *5, *6, *7, *8, *9 and *10 polymorphisms. The genotype
frequencies were detected as 38.89% for *1/*1, 16.67% for *1/*2, 11.11% for *2/*17, 1.85% for
*1/*3, 1.85% for *2/*3, 27.78% for *1/*17 and 1.85% for *17/*17. According to genotype analysis,
1.85% of the patients were recorded as poor and 29.63% intermediate; whereas 27.78% as rapid and
1.85% ultra-rapid metabolizers.

Conclusion:
Although our study population does not consist of a high number of patients, since the
high frequency of intermediate, rapid and ultra-rapid metabolizer patients were detected in relatively
high frequencies, CYP2C19 polymorphisms should be taken into account for efficiency and possible
clopidogrel related risks in Turkish cardiac patients.
Text Messaging Versus Email Messaging to Support Patients With Major Depressive Disorder: Protocol for a Randomized Hybrid Type II Effectiveness-Implementation Trial
Authors: Adu Medard Kofi , Shalaby Reham , Eboreime Ejemai , Sapara Adegboyega , Nkire Nnamdi , Chawla Rajan , Chima Chidi , Achor Michael , Osiogo Felix , Chue Pierre , Greenshaw Andrew J , Agyapong Vincent Israel 
Published: September 2021

Background
Major depressive disorder (MDD) accounts for 40.5% of disability-adjusted life years caused by mental and substance use disorders. Barriers such as stigma and financial and physical access to care have been reported, highlighting the need for innovative, accessible, and cost-effective psychological interventions. The effectiveness of supportive SMS text messaging in alleviating depression symptoms has been proven in clinical trials, but this approach can only help those with mobile phones.

Objective
This paper presents the protocol for a study that will aim to evaluate the feasibility, comparative effectiveness, and user satisfaction of daily supportive email messaging as an effective strategy compared to daily supportive text messaging as part of the treatment of patients with MDD.

Methods
This trial will be carried out using a hybrid type II implementation-effectiveness design. This design evaluates the effectiveness of an implementation strategy or intervention, while also evaluating the implementation context associated with the intervention. Patients with MDD receiving usual care will be randomized to receive either daily supportive email messaging or daily supportive text messaging of the same content for 6 months. The Patient Health Questionnaire-9, the Generalized Anxiety Disorder-7, and the 5-item World Health Organization Well-Being Index will be used to evaluate the effectiveness of both strategies. The implementation evaluation will be guided by the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework, as well as the Consolidated Framework for Implementation Research. All outcome measures will be analyzed using descriptive and inferential statistics. Qualitative data will be analyzed using thematic analysis.

Results
Data collection for this trial began in April 2021. We expect the study results to be available within 18 months of study commencement. The results will shed light on the feasibility, acceptability, and effectiveness of using automated emails as a strategy for delivering supportive messages to patients with MDD in comparison to text messaging.

Conclusions
The outcome of this trial will have translational impact on routine patient care and access to mental health, as well as potentially support mental health policy decision-making for health care resource allocation.

Trial Registration
ClinicalTrials.gov NCT04638231; https://clinicaltrials.gov/ct2/show/NCT04638231

International Registered Report Identifier (IRRID)
DERR1-10.2196/29495