bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation of MnO2 modified magnetic graphitic carbon nitride composite and its adsorption toward Pb(II) in waste water
Authors: Xia Wenning , Liu Yaochi 
Published: June 2021

AbstractBased on graphitic carbon nitride (CN) nanosheets, a novel MnO2 modified magnetic graphitic carbon nitride composite (MMCN) was prepared via magnetization and in-situ deposition of MnO2. Then, an array of characterizations and experiments were conducted to explore the physical and chemical properties of the synthesized MMCN material. The adsorption behavior and removal mechanism of the MMCN were also discussed intensively. The best pH value of Pb(II) of MMCN was 6. The maximum adsorption capacity of MMCN was as high as 187.6 mg/g, which was much higher than that of MCN and original CN, and removal percentage of Pb(II) was about 99%. The adsorption kinetics and isotherms were in accordance with the pseudo-second-order model and Langmuir model, respectively. The chemical adsorption of Pb(II) indicated that MMCN was a successful modified sorbent and pretty efficient to remove Pb(II) in an aqueous medium owing to the complexation and ion exchange of ample amino and hydroxyl groups. Moreover, MMCN could be separated easily from the aqueous medium under an external field after reaction with its magnetic performance.
Neurological Effects of SARS-CoV-2 and Neurotoxicity of Antiviral Drugs Against COVID-19
Authors: Ünlü Büşra , Simsek Rahime , Köse Selinay Başak Erdemli , Yirün Anıl , Erkekoglu Pinar 
Published: June 2021

Abstract:Severe Acute Respiratory Syndrome (SARS) is caused by different SARS viruses. In 2020, novel coronavirus (SARS-CoV-2) led to an ongoing pandemic, known as “Coronavirus Disease 2019 (COVID-19)”. The disease can spread among individuals through direct (via saliva, respiratory secretions, or secretion droplets) or indirect (through contaminated objects or surfaces) contact. The pandemic has spread rapidly from Asia to Europe and later to America. It continues to affect all parts of the world at an increasing rate. There have been over 92 million confirmed cases of COVID-19 by mid-January 2021. The similarity of homological sequences between SARS-CoV-2 and other SARSCoVs is high. In addition, clinical symptoms of SARS-CoV-2 and other SARS viruses show similarities. However, some COVID-19 cases show neurologic signs like headache, loss of smell, hiccups and encephalopathy. The drugs used in the palliative treatment of the disease also have some neurotoxic effects. Currently, there are approved vaccines for COVID-19. However, there is a need for specific therapeutics against COVID-19. This review will describe the neurological effects of SARS-CoV-2 and the neurotoxicity of COVID-19 drugs used in clinics. Drugs used in the treatment of COVID-19 will be evaluated by their mechanism of action and their toxicological effects.
SARS-Cov-2 Damage on the Nervous System and Mental Health
Authors: Boulkrane Mohamed Said , Ilina Victoria , Melchakov Roman , Arisov Mikhail , Fedotova Julia , Gozzo Lucia , Drago Filippo , Lu Weihong , Sarapultsev Alexey , Tseilikman Vadim , Baranenko Denis 
Published: June 2021

:The World Health Organization declared the pandemic situation caused by SARSCoV- 2 (Severe Acute Respiratory Syndrome Coronavirus-2) in March 2020, but the detailed pathophysiological mechanisms of Coronavirus disease 2019 (COVID-19) are not yet completely understood. Therefore, to date, few therapeutic options are available for patients with mildmoderate or serious disease. In addition to systemic and respiratory symptoms, several reports have documented various neurological symptoms and impairments of mental health. The current review aims to provide the available evidence about the effects of SARS-CoV-2 infection on mental health. The present data suggest that SARS-CoV-2 produces a wide range of impairments and disorders of the brain. However, a limited number of studies investigated the neuroinvasive potential of SARS-CoV-2. Although the main features and outcomes of COVID-19 are linked to severe acute respiratory illness, the possible damages on the brain should be considered, too.
MBMM: Moment Estimating Beta Mixture Model-based Clustering Algorithm for m6A Co-methylation Module Mining
Authors: Liu Zhaoyang , Yin Hongsheng , Chen Shutao , Liu Hui , Meng Jia , Wang HongLei , Zhang Lin 
Published: June 2021

Background:
m6A methylation is a ubiquitous post-transcriptional modification that exists
in mammals. MeRIP-seq technology makes the acquisition of m6A data in the whole transcriptome
under different conditions realizable. The specific regulation of the enzyme will present comethylation
module on m6A methylation level data. Thus, mining the co-methylation module from
which can help to unveil the mechanism of m6A methylation modification and its mechanism in the
occurrence and development of complex diseases such as cancer.

Objective:
To develop a clustering algorithm that can effectively realize the mining of m6A comethylation
module.

Methods:
In this study, a novel beta mixture model-based clustering algorithm named MBMM was
proposed, which is based on the EM framework and introduces the method of moment estimating in
M-step for parameter estimation to tackle the high-dimensional small sample m6A data. Simulation
research was employed to evaluate the clustering performance of the proposed algorithm, and by
which the co-methylation module mining was done based on real data. Biological significance correlation
analysis was employed to explore whether the clustering results are co-methylation modules.

Results and Conclusion:
Simulation research demonstrated that MBMM performed out than other
clustering algorithms. In real data, seven co-methylation modules were found by MBMM. Six m6Arelated
pathways specific analysis showed that six co-methylation modules were enriched in the
pathway and were different. Five enzymes substrate-specific analysis revealed that seven comethylation
modules expressed varying degrees of enrichment. Gene Ontology enrichment analysis
indicated that these modules may be regulated by enzymes while having potential functional specificity.
A Praça Nelson Mandela: Espacialidades em Fronteira
Authors: Nakagawa Regiane Miranda de Oliveira 
Published: June 2021

Este artigo apresenta o resultado parcial de uma pesquisa mais ampla, realizada no bairro Lavapiés, região central de Madrid, voltada a apreender a constituição de suas distintas espacialidades e os sentidos que elas geram na cultura. A discussão aqui proposta terá como objeto a praça Nelson Mandela, um dos principais pontos de encontro de imigrantes na região, com o intuito de verificar de que maneira ocorre a emersão de espacialidades pautadas pelos intercâmbios e tensionamentos entre os diferentes grupos que frequentam o espaço. Para tanto, a análise terá por base a ambivalência que caracteriza o funcionamento da fronteira semiótica, tal como ela foi definida pelo semioticista da cultura Iuri Lotman (1996). A deriva situacionista e a observação participante foram utilizadas como método de pesquisa. Na praça, nota-se a presença de duas espacialidades distintas: uma marcada por um distanciamento que resulta em relações pautadas por aquilo que Richard Sennett (2018/2019) indica ser o “próximo-estranho” e outra caracterizada por intercâmbios tradutórios pelos quais se constrói uma cidade diferente daquela planejada pelo urbanismo. Por meio da discussão, objetiva-se ainda pontuar de que maneira, por meio da fronteira, se torna possível apreender formas de constituição da cidade pidgin (Careri, 2016/2017), que emergem em meio a relações marcadas pela imprevisibilidade e pelo erro, decorrentes das interações estabelecidas entre distintas alteridades.
Use of Iris Scanning for Biometric Recognition of Healthy Adults Participating in an Ebola Vaccine Trial in the Democratic Republic of the Congo: Mixed Methods Study
Authors: Zola Matuvanga Trésor , Johnson Ginger , Larivière Ynke , Esanga Longomo Emmanuel , Matangila Junior , Maketa Vivi , Lapika Bruno , Mitashi Patrick , Mc Kenna Paula , De Bie Jessie , Van Geertruyden Jean-Pierre , Van Damme Pierre , Muhindo Mavoko Hypolite 
Published: June 2021

Background
A partnership between the University of Antwerp and the University of Kinshasa implemented the EBOVAC3 clinical trial with an Ebola vaccine regimen administered to health care provider participants in Tshuapa Province, Democratic Republic of the Congo. This randomized controlled trial was part of an Ebola outbreak preparedness initiative financed through Innovative Medicines Initiative-European Union. The EBOVAC3 clinical trial used iris scan technology to identify all health care provider participants enrolled in the vaccine trial, to ensure that the right participant received the right vaccine at the right visit.

Objective
We aimed to assess the acceptability, accuracy, and feasibility of iris scan technology as an identification method within a population of health care provider participants in a vaccine trial in a remote setting.

Methods
We used a mixed methods study. The acceptability was assessed prior to the trial through 12 focus group discussions (FGDs) and was assessed at enrollment. Feasibility and accuracy research was conducted using a longitudinal trial study design, where iris scanning was compared with the unique study ID card to identify health care provider participants at enrollment and at their follow-up visits.

Results
During the FGDs, health care provider participants were mainly concerned about the iris scan technology causing physical problems to their eyes or exposing them to spiritual problems through sorcery. However, 99% (85/86; 95% CI 97.1-100.0) of health care provider participants in the FGDs agreed to be identified by the iris scan. Also, at enrollment, 99.0% (692/699; 95% CI 98.2-99.7) of health care provider participants accepted to be identified by iris scan. Iris scan technology correctly identified 93.1% (636/683; 95% CI 91.2-95.0) of the participants returning for scheduled follow-up visits. The iris scanning operation lasted 2 minutes or less for 96.0% (656/683; 95% CI 94.6-97.5), and 1 attempt was enough to identify the majority of study participants (475/683, 69.5%; 95% CI 66.1-73.0).

Conclusions
Iris scans are highly acceptable as an identification tool in a clinical trial for health care provider participants in a remote setting. Its operationalization during the trial demonstrated a high level of accuracy that can reliably identify individuals. Iris scanning is found to be feasible in clinical trials but requires a trained operator to reduce the duration and the number of attempts to identify a participant.

Trial Registration
ClinicalTrials.gov NCT04186000; https://clinicaltrials.gov/ct2/show/NCT04186000
A Web-Based Intervention to Increase Smokers’ Intentions to Participate in a Cessation Study Offered at the Point of Lung Screening: Factorial Randomized Trial
Authors: Neil Jordan M , Chang Yuchiao , Goshe Brett , Rigotti Nancy , Gonzalez Irina , Hawari Saif , Ballini Lauren , Haas Jennifer S , Marotta Caylin , Wint Amy , Harris Kim , Crute Sydney , Flores Efren , Park Elyse R 
Published: June 2021

Background
Screen ASSIST is a cessation trial offered to current smokers at the point of lung cancer screening. Because of the unique position of promoting a prevention behavior (smoking cessation) within the context of a detection behavior (lung cancer screening), this study employed prospect theory to design and formatively evaluate a targeted recruitment video prior to trial launch.

Objective
The aim of this study was to identify which message frames were most effective at promoting intent to participate in a smoking cessation study.

Methods
Participants were recruited from a proprietary opt-in online panel company and randomized to a 2 (benefits of quitting vs risks of continuing to smoke at the time of lung screening; BvR) × 2 (gains of participating vs losses of not participating in a cessation study; GvL) message design experiment (N=314). The primary outcome was self-assessed intent to participate in a smoking cessation study. Message effectiveness and lung cancer risk perception measures were also collected. Analysis of variance examined the main effect of the 2 message factors and a least absolute shrinkage and selection operator (LASSO) approach identified predictors of intent to participate in a multivariable model. A mediation analysis was conducted to determine the direct and indirect effects of message factors on intent to participate in a cessation study.

Results
A total of 296 participants completed the intervention. There were no significant differences in intent to participate in a smoking cessation study between message frames (P=.12 and P=.61). In the multivariable model, quit importance (P<.001), perceived message relevance (P<.001), and affective risk response (ie, worry about developing lung cancer; P<.001) were significant predictors of intent to participate. The benefits of quitting frame significantly increased affective risk response (Meanbenefits 2.60 vs Meanrisk 2.40; P=.03), which mediated the relationship between message frame and intent to participate (b=0.24; 95% CI 0.01-0.47; P=.03).

Conclusions
This study provides theoretical and practical guidance on how to design and evaluate proactive recruitment messages for a cessation trial. Based on our findings, we conclude that heavy smokers are more responsive to recruitment messages that frame the benefits of quitting as it increased affective risk response, which predicted greater intention to participate in a smoking cessation study.
Fuzzy Clustering Algorithm to Catching Pattern of Change in District/City Poverty Variables Before and The Beginning of The Covid-19 Pandemic in Sulawesi Island
Authors: Novidianto Raditya , Irfani Rini 
Published: June 2021

The first goal of the SDGs is to end poverty in any form. The COVID-19 pandemic has greatly affected several economic indicators, especially absolute poverty, especially in Sulawesi Island, which has increased poverty indicators, leading to the movement of values between districts/cities. The grouping will show similar characteristics of absolute variable poverty. By the Fuzzy method clustering, each observation has a degree of membership so that from the degree of membership can be identified which areas have vulnerable to move from one cluster to another. Grouping using fuzzy algorithms will get an overview of districts of concern to the government during the pandemic so that the variable indicators of absolute poverty do not worsen due to the pandemic. Comparison with the absolute variables of poverty in 2019 and 2020 in the headcount index (P0), Poverty Gap Index (P1), and Poverty Severity Index (P2) in districts/cities on the island of Sulawesi based on silhouette coefficients shows that optimum clusters formed as many as 2 clusters, with a coefficient of 0.57 and 0.60 respectively. Cluster 1 has characteristics including areas with absolute poverty rates that tend to be more prosperous than cluster 2 in the 2019 and 2020 data groups on the island of Sulawesi. The fuzzy algorithm detects areas prone to displacement from cluster 1 to cluster 2, namely Bombana, Bone, Sangihe Islands, South Konawe, and Siau Tagulandang Biaro in 2019 and Bombana, Bone, Sangihe, and Maros Islands in 2020. The COVID-19 pandemic in March 2020 has not had much impact on the macro indicators of poverty seen in the transfer of membership from 2019 to 2020, which only occurred to 3 districts that changed, namely bolaang mongondouw and konawe selatan from cluster 1 to cluster 2 and Maros from cluster 2 to cluster 1.
Comparto Paesaggio: Innovare senza perturbare
Authors: Genovese Virginia , Simone Edvige , Spisso Manuela Lucia 
Published: June 2021

Le leggi che si sono succedute dal 1948 ad oggi hanno modificato e dato
forza alla tutela del paesaggio, stabilendo che per paesaggio si intende
la stratificazione delle azioni antropiche e naturali. Per sottolineare
la complessità e l’importanza del paesaggio è stato proposto il caso
studio di un impianto eolico off-shore. Attraverso la relazione
paesaggistica è stato esaminato lo stato attuale del paesaggio naturale
ed urbano in cui è inserito il progetto ed è stata stimata l’incidenza
che tale progetto avrà sul contesto.
Tecniche di individuazione degli impatti: analisi delle potenziali applicazioni
Authors: D'Ambrosi Pietro , Giaquinto Pietro 
Published: June 2021

Per poter realizzare un progetto verificando coerentemente la
compatibilità dello stesso con i comparti ambientali con cui
quest’ultimo interagisce, è necessario eseguire correttamente le varie
fasi inerenti alla valutazione ambientale. Prefissata quindi la
determinata opera che si intende realizzare, è fondamentale scegliere
anzitutto tra le alternative a disposizione quella che minimizzi le
pressioni negative esercitate sul territorio. Scelta l’alternativa
idonea si passa allo studio delle interazioni tra la stessa e i comparti
ambientali inerenti all’area in questione.
La seguente analisi passa rispettivamente per l’identificazione, la
stima e quindi la valutazione dei potenziali impatti.
Eseguite le suddette fasi è possibile valutare se siano necessari o meno
eventuali interventi di mitigazione o compensazione e quindi, effettuata
la valutazione degli impatti residui, verificare la compatibilità
ambientale del progetto con i comparti interagenti con esso.
In caso di impatti negativi significativi è necessario valutare
un’alternativa al progetto o di localizzazione. Viceversa, constatata
dall’ imprenditore la sostenibilità economica dell’opera, è possibile
passare alla redazione dello Studio di Impatto Ambientale.
La fase di identificazione degli impatti è fondamentale per garantire la
considerazione di tutti gli aspetti ambientali con cui l’opera
interagisce direttamente e indirettamente, oltre che evitare di
trascurare eventuali azioni progettuali comportanti potenziali impatti.
O desequilíbrio econômico financeiro do contrato de concessão por inadimplemento do usuário como critério objetivo e legitimador da interrupção do serviço público à luz dos princípios do Estado Constitucional de Direito
Authors: Almeida Fabrício Bolzan de 
Published: June 2021

A presente tese de doutoramento foi divida em três partes: Parte I – Serviço Público; Parte II – Continuidade do Serviço Público; e, Parte III – Critério Legitimador da Interrupção do Serviço Público. Na parte inicial, abordamos os fundamentos constitucionais e infraconstitucionais do instituto serviço público e trouxemos as principais definições trazidas pela doutrina administrativista, além da nossa proposta de conceituação. Demonstramos ainda o regime jurídico de direito público e a importância da Escola Francesa de Direito para a construção da noção de serviço público. Na segunda parte desta tese entraremos no enfrentamento de um ponto de extrema relevância, o princípio da continuidade do serviço público. Para tanto, abordamos as noções de consumidor e de usuário do serviço público, bem como as diferenças principais entre tarifas e taxas no tocante à espécie de contraprestação pecuniária remuneratória dos serviços públicos. Traremos à colação a visão da doutrina nacional contemporânea sobre a possibilidade ou não da interrupção do serviço público em razão do inadimplemento do usuário, bem como a posição dominante e as exceções na jurisprudência do Superior Tribunal de Justiça. A parte derradeira desta tese será elaborada com o intuito de construir aquilo que defendemos como sendo um critério objetivo e legitimador da interrupção do serviço público em razão do inadimplemento do usuário, considerado o interesse da coletividade, conforme determina a Lei Geral de Concessões e Permissões dos Serviços Públicos e à luz dos Princípios Constitucionais do Estado Democrático de Direito.
Analisis Pemanfaatan Panas Mesin Kendaraan Menjadi Sumber Energi Listrik Pada Kendaraan Bermotor Dengan Menggunakan Efek Seeback Pada Thermoelektrik Generator
Authors: Syafrianto Syafrianto , Lapisa Remon 
Published: June 2021

This study discusses the analysis of the heat utilization of vehicle engines into electrical energy using the seeback effect on the thermoelectric generator. This type of research is a level 3 development research with several stages, namely: potential and problems, product design, system validation, design revision, product manufacturing, testing product trials, product revisions, usage trials, product revisions. Based on the research conducted, several things can be concluded, namely. First, the use of the level 3 development research method can be applied in research on analyzing the use of vehicle engine heat into electrical energy using the seeback effect on the thermoelectric generator. Second, when testing the thermoelectric generator, it is carried out 2 times, so that the electrical energy is obtained from a temperature difference of 70.1 ° C of 2.98 volts.
Penelitian ini membahas mengenai analisis pemanfaatan panas mesin kendaraan menjadi energi listrik dengan menggunakan efek seeback pada thermoelektrik generator. Jenis penelitian ini adalah penelitian pengembangan level 3 dengan beberapa tahap, yakni: potensi dan masalah, desain produk, validasi sistem, ,revisi desain, pembuatan produk, uji coba produk, revisi produk, uji coba pemakaian, revisi produk.Berdasarkan penelitian yang dilakukan dapat disimpulkan beberapa hal, yaitu. Pertama penggunaan metode penelitian pengembangan level 3 dapat diterapkan dalam penelitian analisis pemanfaatan panas mesin kendaraan menjadi energi listrik dengan menggunakan efek seeback pada thermoelektrik generator. Kedua pada saat melakukan pengujian terhadap thermoelektrik generator dilakukan sebanyak 2 kali, sehingga didapatkanlah energi listrik yang dihasilkan dari perbedaan temperatur 70.1 °C sebesar 2,98 Volt.
Pengaruh Perubahan Arus Kas Yang Dimoderasi Oleh Korelasi Serial Dalam Perubahan Arus Kas Dalam Memprediksi Akrual
Authors: Nurjannah Nurjannah , Sebrina Nurzi 
Published: June 2021

The purpose of this study was to examine the effect of cash flow change serial correlation in moderating the relationship of cash flow change and accruals. This study is classified as causative research. The population in study are manufacturing companies listed on the Indonesia Stock Exchange of period 2016 to 2018. By using purposive sampling method, there were 43 companies as the research’s sampel. The type of data used is secondary data obtained from the official site of the Indonesia Stock Exchange and company’s official website. Used is panel regression analysis. The result indicate that cash flow changes has negative and siginificant effect on accrual, but cash flow changes serial correlation is not able to strengthen or weaken the relationship between cash flow changes and accrual.
Pengaruh Pengetahuan Akuntansi Dan Skala Usaha Mikro Kecil Dan Menengah Terhadap Penyusunan Laporan Keuangan SAK EMKM
Authors: Satiya Ibnu , Sebrina Nurzi , Mulyani Erly 
Published: June 2021

Tujuan dari penelitian ini adalah untuk menganalisis pengaruh pengetahuan akuntansi dan skala usaha terhadap Penyusunan laporan keuangan SAK EMKM. Data yang digunakan dalam penelitian adalah data primer. Metode pengambilan sampel menggunakan metode Rumus Slovin. Berdasarkan metode pengambilan diperoleh sampel sebanyak 55 UMKM. Pengujian hipotesis dalam penelitian ini menggunakan analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa pengetahuan akuntansi berpengaruh pada Penyusunan laporan keuangan SAK EMKM, sedangkan skala usaha tidak memberikan pengaruh