bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metodologia ativa de aprendizagem no plano municipal de educação de Jataí-Go
Authors: Costa Cunha Rodolfo 
Published: November 2021

A pesquisa objetivou analisar o Plano Municipal de Educação (PME) de Jataí – GO, para evidenciar se a Metodologia Ativa de Aprendizagem (MAA) compõe as estratégias de melhoria do ensino na Educação de Jovens e Adultos e na Educação Profissional e Tecnológica. Para isso, analisaram-se três metas do PME (7, 10 e 11). Utilizou-se a pesquisa exploratória, análise de conteúdo e a técnica de análise documental. Considerou-se, como unidade de registro, a expressão: Metodologia Ativa de Aprendizagem. Escolheu-se a contagem por frequência simples. Observou-se frequência zero. Concluiu-se que a MAA não compõe as estratégias educacionais do PME, nas modalidades supracitadas.
RANCANG BANGUN DUPLEXER PADA SYSTEM PEMANCAR DAN PENERIMA RADIO HYBRID CIGRA
Authors: Prabowo Choirul Rio , Ashar Imam , Gunawan Petrus 
Published: November 2021

Perkembangan teknologi saat ini sangatlah berkembang dengan pesat, komunikasi sangat penting dan dibutuhkan, Peneltian ini bertujuan untuk merancang bangun sebuah perangkat Duplexer yang bekerja pada band 900 MHz pada jaringan radio hybrid. Duplexer adalah perangkat yang menggunakan satu antena pada frekuensi yang berbeda. Pada penelitian ini menggunakan metode kuantitatif, karena hanya satu antenna yang dapat berkomunikasi antara dua HT, duplexer didesain menggunakan mikrostrip sebagai resonator. Komponen L dan C pada mikrostrip ini menggunakan teknik open circuit untuk kapasitor dan short circuit untuk induktor. Duplexer diperoleh dengan memanfaatkan respon frekuensi band stop filter (BSF). Frekuensi yang digunakan pada band 900 Mhz yang mana frekuensi uplink adalah 453,025 MHz – 463,025 MHz dan frekuensi downlink 458.025 MHz – 468.025 MHz.Hasil pengujian diperoleh redaman pada cut off mencapai 12 db. Redaman ini merupakan tingkat isolasi sinyal antara sinyal uplink dan downlink.
PENGARUH DEEP BACK MASSAGE TERHADAP INTENSITAS NYERI PERSALINAN KALA I FASE AKTIF DI RUANG BERSALIN RUMAH SAKIT IMMANUDIN KABUPATEN KOTAWARINGIN BARAT
Authors: Oktarina Jenny , Asriana Ayu , Arti Muni 
Published: November 2021

Persalinan merupakan proses menanti kelahiran yang akan dilalui seorang ibu dengan penuh rasa nyeri tetapi hal tersebut dapat teratasi dengan melakukan penekanan pada daerah sacrum secara mantap dengan telapak tangan, lepaskan dan tekan lagi atau disebut dengan deep back massage. Tujuan penelitian ini untuk menganalisis Pengaruh Deep Back Massage terhadap intensitas nyeri persalinan kala 1 fase aktif di Ruang Bersalin Rumah Sakit immanudin Kabupaten kotawaringin barat Tahun 2017. Desain penelitian adalah penelitian Pra Eksperiment dengan pendekatan metode One Group Pra-Post Test Design. Populasinya semua ibu bersalin pada saat penelitian, dengan sampel 21 responden diambil dengan tekhnik accidental sampling. Pengumpulan data dengan observasi.Dari hasil penelitian sebelum perlakuan hampir setengah responden mengalami nyeri berat terkontrol sebanyak 8 responden (38,1%) dan setelah perlakuan hampir setengah responden mengalami nyeri sedang sebanyak 8 responden (38,1%).Hasil analisa data menggunakan uji-T dengan nilai sig (2-tailed) : 0,000 dan : 0,05, jadi < sehingga H0 ditolak dan H1 diterima, artinya ada perbedaan intensitas nyeri persalinan sebelum dan sesudah diberikan deep back massage. Diharapkan hasil penelitian ini dapat digunakan sebagai alternatif penurunan rasa nyeri pada persalinan dengan mudah dilakukan tanpa efek yang membahayakan dalam memberikan intervensi pada ibu selama persalinan kala I fase aktif.
PERBEDAAN TINGKAT KECEMASAN IBU PRA MENOPAUSE SEBELUM DAN SESUDAH DIBERI KONSELING INFORMASI EDUKASI (KIE) TENTANG MENOPAUSE
Authors: Suprapti Dwi 
Published: November 2021

Menopause merupakan hal yang fisiologis dialami oleh setiap wanita yang ditandai dengan berhentinya masa subur. Masa ini akan mengalami keluhan baik fisik maupun psikologis yang berpengaruh terhadap kecemasan seseorang. Kecemasan adalah respon individu terhadap suatu keadaan yang tidak menyenangkan dan dialami oleh semua orang. Kecemasan tersebut dapat teratasi jika ibu mempunyai pengetahuan yang cukup tentang menopause, sehingga ibu perlu mengikuti kegiatan pendidikan kesehatan tentang menopause. Tujuan penelitian ini untuk mengetahui perbedaan tingkat kecemasan ibu pra menopause sebelum dan sesudah diberi KIE tentang menopause.Metode penelitian ini menggunakan pre-eksperimental design dengan teknik one group pre-test post-test, populasi penelitian sebanyak 201 orang dan sampel sebanyak 20 ibu pra menopause usia 41-50 tahun dengan pengambilan sampel menggunakan simple random sampling dan data analisis menggunakan uji paried T- test.Hasil penelitian menunjukkan bahwa ada perbedaan yang signifikan pemberian KIE tentang menopause terhadap tingkat kecemasan ibu pra menopause pada pre-test tingkat kecemasan ringan sebanyak 40,0%, cemas sedang 55,0%, dan cemas berat 5,0% dan mengalami penurunan pada saat post-test dengan tingkat kecemasan ringan 60,0%, sedang 35,0%, dan berat tidak ada kecemasan 0% dengan p-value = 0,000 (p < 0,05). Dan pada hasil penelitian menunjukkan bahwa sebelum diberikan KIE tentang menopause rata-rata skor kecemasan ibu sebesar 16,40, kemudian berkurang menjadi 13,15 setelah diberikan KIE tentang menopause.Saran bagi masyarakat terutama wanita pra menopause diharapkan dapat meningkatkan pengetahuan tentang menopause sehingga dapat menurunkan tingkat kecemasan dan lebih siap lagi dalam menghadapi menopause. Kata kunci : Kecemasan, Ibu Pra Menopause, KIE (Komunikasi Informasi Edukasi)
STUDI KOMPARATIF KEPUASAN PASIEN RAWAT JALAN UMUM DAN PERUSAHAAN DI POLIKLINIK MCU RSUD SULTAN IMANUDDIN PANGKALAN BUN
Authors: Nerlisa Nerlisa , Ningtyas Rahaju , Wiludjeng Rahaju 
Published: November 2021

Kualitas pelayanan kesehatan tergambar pada tingkat kepuasan pasien. Taraf hidup masyarakat mempengaruhi tuntutan masyarakat terhadap kualitas kesehatan. Pelayanan rawat jalan di RSUD Sultan Imannudin dibagi menjadi dua sesuai dengan cara pembayarannya yaitu pasien asuransi dan umum. Tujuan dalam penelitian ini adalah untuk mengetahui komparatif kepuasan pasien rawat jalan umum dan perusahaan di Poliklinik MCU RSUD Sultan Imanuddin.Penelitian ini menggunakan metode non eksperiment : komparatif. yaitu untuk mengetahui perbedaan kepuasan pasien rawat jalan dengan jaminan perusahaan dan umum.Hasil penelitian berdasar Wilcoxon sigred rank test dengan nilai p=0.000 < 0,05 yang artinya terdapat perbedaan yang signifikan antara kepuasan pasien rawat jalan umum dan kepuasan pasien rawat jalan perusahaan. Tingkat kepuasan pasien umum adalah puas, sementara tingkat kepuasan pasien perusahaan sangat puas. Hal ini dikarenakan dari faktor pembiayaan. Tingkat kepuasan pasien rawat jalan perusahaan sangat puas dikarenakan dari segi finansial mereka tidak perlu memikirkannya lagi. Pasien tertanggung (pasien perusahaan) hanya menerima pelayanan yang diberikan kepada mereka. Sementara pasien umum merasa puas karena mereka harus membayar biaya pegobatan, sehingga tuntutan terhadap mutu pelayanan juga tinggi.Disarankan bahwa penilaian tingkat kepuasan pasien dilakukan rutin dan berkala sebagai bahan masukan untuk mengambil kebijakan dalam peningkatan kualitas pelayanan terutama lebih difokuskan untuk dimensi reability (kehandalan). Kata kunci: Studi komparasi, Kepuasan ,Pasien rawat jalan umum dan perusahaan
Computational Methods for Legal Analysis
Authors: Kantorowicz-Reznichenko Elena 
Published: November 2021

Computational Methods for Legal Analysis
Computational analysis can be seen as the most recent innovation in the field of Empirical Legal Studies (ELS). It concerns the use of computer science and big data tools to collect, analyse and understand the large and unstructured data, such as for instance (legal) text. Given that the text is now the object of analysis, but the methods are (largely) quantitative, it lies in the intersection between doctrinal analysis and ELS. It brings with it not only a great potential to scale up research and answer old research questions, but also to reveal uncovered patterns and address new questions. Despite a slowly growing number of legal scholars who are already applying such methods, it is underutilised in the field of law. Furthermore, given that this method comes from social and computer sciences, many legal scholars are not even aware of its existence and potential. Therefore, the purpose of this special issue is not only to introduce these methods to lawyers and discuss possibilities of their application, but also to pay special attention to the challenges, with a specific emphasis on the ethical issues arising from using ‘big data’ and the challenge of building capacity to use such methods in law schools. This editorial briefly explains some of the methods which belong to the new movement of Computational Legal Analysis and provides examples of their application. It then introduces those articles included in this special issue. Finally, it provides a personal note on the way forward for lawyers within the movement of Computational Legal Analysis
Comparison of Incidence of Inguinal Hernia among Obese and Normal Individuals: A Retrospective Analysis
Authors: Zade Mandar , Sridharan Sivaram 
Published: November 2021

Objective: The objective of the present study was to verify whether obesity is associated with the occurrence of inguinal hernia.
This is a cross-sectional study carried out in a tertiary hospital, including 84 patients, with clinical diagnosis of inguinal hernia, who underwent hernia mesh repair during a 6-month period (January 2021 to June 2021). Demographic, anthropometric and diagnostic data for inguinal hernia were taken from the patients' medical records.
The Chi-square test was used to calculate the significance of association.
Results: A total of 84 patients were included in this study. The age of patients varied between 39 - 75 years, averaging 54.8 years.
The study showed an association between BMI and two factors, namely: Age (P = .023) and size of the defect (P = .005). However, hernia type (P = .797) and its content (P = 0.061) did not show such an association.
Conclusion: In conclusion, these results may be a useful guide for future studies about the relationship between BMI and hernia and may provide foundation for better understanding of the pathophysiology of hernia is obese.
Gallium‐Based Liquid Metal Reaction Media for Interfacial Precipitation of Bismuth Nanomaterials with Controlled Phases and Morphologies
Authors: Mayyas Mohannad , Khoshmanesh Khashayar , Kumar Priyank , Mousavi Maedehsadat , Tang Jianbo , Ghasemian Mohammad B. , Yang Jiong , Wang Yifang , Baharfar Mahroo , Rahim Md. Arifur , Xie Wanjie , Allioux Francois‐Marie , Daiyan Rahman , Jalili Rouhollah , Esrafilzadeh Dorna , Kalantar‐Zadeh Kourosh 
Published: November 2021

AbstractLiquid–liquid interfaces of liquid alloys with electrolytic solutions present fertile platforms for realizing exciting interfacial phenomena that can be devised to process alloys and produce nanomaterials. Here, such an interface is established by immersing a gallium–bismuth binary liquid alloy into aqueous electrolytes. It is shown that the application of a negative voltage to this interface results in a rapid and complete liberation of bismuth nanostructures from liquid gallium. The set of conditions that govern the chemistry of the interface can be adjusted to control the oxidation state, morphology, and crystal structure of the expelled bismuth. By changing the conditions; nanotubular, atomically thin plates, and sea‐urchin‐shaped bismuth oxide morphologies are obtained. The process can also control the crystal phase of bismuth oxide as monoclinic (α), tetragonal (β), or body‐centered cubic (γ). The addition of ascorbic acid to the electrolyte is observed to prevent the oxidation of the expelled entities, resulting in bismuth metal nanoparticles. Ab initio molecular dynamics and computational fluid dynamics simulations are performed to elucidate this rapid phase separation at the interface. This knowledge will potentially lead to new pathways for using alloys as reaction media to refine metals while simultaneously producing nanomaterials for various applications.
Emergent Photostability Synchronization in Coassembled Array Members for the Steady Multiple Discrimination of Explosives
Authors: Cheng Chuanqin , Cui Linfeng , Xiong Wei , Gong Yanjun , Ji Hongwei , Song Wenjing , Zhao Jincai , Che Yanke 
Published: November 2021

AbstractThe design of sensor array members with synchronous fluorescence and photostability is crucial to the reliable performance of sensor arrays in multiple detections and their service life. Herein, a strategy is reported for achieving synchronous fluorescence and photostability on two coassemblies fabricated from carbazole‐based energy donor hosts and a photostable energy acceptor. When a small number of the same energy acceptors are embedded into two carbazole‐based energy donor hosts, the excitation energy of the donors can be efficiently harvested by the acceptors through long‐range exciton migration and Förster resonance energy transfer (FRET) to achieve synchronous fluorescence and photostability in both coassemblies. More intriguingly, the synchronous photostability substantially improves the multiple discrimination capacity (e.g., 10 times more discriminations of TNT in two coassemblies have been achieved compared to the sensor array comprising two individual donor assemblies) and the working lifetime of the sensor array. The concept of optical synchronization (i.e., emission and photostability) of sensor array members can be extended to other sensor arrays for the steady multiple detection of certain hazardous chemicals.
On‐DNA Transfer Hydrogenolysis and Hydrogenation for the Synthesis of DNA‐Encoded Chemical Libraries
Authors: Stanway‐Gordon Harriet A. , Graham Jessica S. , Waring Michael J. 
Published: November 2021

AbstractDNA‐encoded libraries (DELs) are an increasingly popular approach to finding small molecule ligands for proteins. Many DEL synthesis protocols hinge on sequential additions of monomers using split‐pool combinatorial methods. Therefore, compatible protecting group strategies that allow the unmasking of reactive functionality (e. g. amines and alcohols) prior to monomer coupling, or the removal of less desirable functionality (e. g., alkenes and alkynes) are highly desirable. Hydrogenation/hydrogenolysis procedures would achieve these ends but have not been amenable to DEL chemistry. We report a catalytic hydrogen transfer reaction using Pd/C, HCONH4 and the micelle‐forming surfactant, TPGS‐750‐M, which gives highly efficient conversions for hydrogenolysis of Cbz‐protected amines and benzyl protected alcohols and hydrogenation of nitros, halides, nitriles, aldehydes, alkenes and alkynes. Application to multicycle synthesis of an encoded compound was fully compatible with DNA‐amplification and sequencing, demonstrating its applicability to DEL synthesis. This method will enable synthetic DEL sequences using orthogonal protecting groups.
An example of project‐based learning with the support of a process simulator applied to the chemical engineering final course project
Authors: Vasconcelos Mateus K. , Guedes Matheus N. , Melo Pedro G. F. , Amore Clara R. , Linares José J. 
Published: November 2021

AbstractAs the culmination of the Chemical Engineering curriculum, students face the challenging and stimulating elaboration of a whole design project that integrates all the knowledge gained throughout the course. The subject is divided into two parts, gaining a theoretical background in the ninth semester and a proposed teamwork project design with the aid of a process simulator in the tenth semester. This paper presents the challenge of designing a whiskey distillery elected by a group of students applying the project‐based learning methodology. As a strategy for a more efficient design, the process is divided into three blocks: prefermentation, fermentation, and distillation. Calculations involve mass and energy balances and the design of the different units, including the optimization of a distillation column assisted by the ASPEN HYSYS® simulator. Students must publicly present their results in front of the class and a jury formed by chemical engineers. A survey was carried out to assess the student's satisfaction and feedback. The results manifested the significance of the subject for the future and the satisfaction of the proposed teaching strategy.
Development of childhood asthma prediction models using machine learning approaches
Authors: Kothalawala Dilini M. , Murray Clare S. , Simpson Angela , Custovic Adnan , Tapper William J. , Arshad S. Hasan , Holloway John W. , Rezwan Faisal I. ,   STELAR/UNICORN investigators
Published: November 2021

AbstractBackgroundRespiratory symptoms are common in early life and often transient. It is difficult to identify in which children these will persist and result in asthma. Machine learning (ML) approaches have the potential for better predictive performance and generalisability over existing childhood asthma prediction models. This study applied ML approaches to predict school‐age asthma (age 10) in early life (Childhood Asthma Prediction in Early life, CAPE model) and at preschool age (Childhood Asthma Prediction at Preschool age, CAPP model).MethodsClinical and environmental exposure data was collected from children enrolled in the Isle of Wight Birth Cohort (N = 1368, ∼15% asthma prevalence). Recursive Feature Elimination (RFE) identified an optimal subset of features predictive of school‐age asthma for each model. Seven state‐of‐the‐art ML classification algorithms were used to develop prognostic models. Training was performed by applying fivefold cross‐validation, imputation, and resampling. Predictive performance was evaluated on the test set. Models were further externally validated in the Manchester Asthma and Allergy Study (MAAS) cohort.ResultsRFE identified eight and twelve predictors for the CAPE and CAPP models, respectively. Support Vector Machine (SVM) algorithms provided the best performance for both the CAPE (area under the receiver operating characteristic curve, AUC = 0.71) and CAPP (AUC = 0.82) models. Both models demonstrated good generalisability in MAAS (CAPE 8‐year = 0.71, 11‐year = 0.71, CAPP 8‐year = 0.83, 11‐year = 0.79) and excellent sensitivity to predict a subgroup of persistent wheezers.ConclusionUsing ML approaches improved upon the predictive performance of existing regression‐based models, with good generalisability and ability to rule in asthma and predict persistent wheeze.
Biocatalytic Alkylation Chemistry: Building Molecular Complexity with High Selectivity
Authors: Ospina Felipe , Schülke Kai H. , Hammer Stephan C. 
Published: November 2021

AbstractBiocatalysis has traditionally been viewed as a field that primarily enables access to chiral centers. This includes the synthesis of chiral alcohols, amines and carbonyl compounds, often through functional group interconversion via hydrolytic or oxidation‐reduction reactions. This limitation is partly being overcome by the design and evolution of new enzymes. Here, we provide an overview of a recently thriving research field that we summarize as biocatalytic alkylation chemistry. In the past 3–4 years, numerous new enzymes have been developed that catalyze sp3 C−C/N/O/S bond formations. These enzymes utilize different mechanisms to generate molecular complexity by coupling simple fragments with high activity and selectivity. In many cases, the engineered enzymes perform reactions that are difficult or impossible to achieve with current small‐molecule catalysts such as organocatalysts and transition‐metal complexes. This review further highlights that the design of new enzyme function is particularly successful when off‐the‐shelf synthetic reagents are utilized to access non‐natural reactive intermediates. This underscores how biocatalysis is gradually moving to a field that build molecules through selective bond forming reactions.
Isolation and Characterization of Both Human and Mouse Tfh/Tfr Cells
Authors: Tulyeu Janyerkye , Søndergaard Jonas N. , Sakaguchi Shimon , Wing James B. 
Published: November 2021

AbstractRegulatory T cells (Tregs) expressing the transcription factor Foxp3 have a critical role for the control of immune homeostasis. The Treg subgroup T follicular regulatory cells (Tfr) have a specialized function to travel to the B cell follicle and control antibody responses. While Tfr may be identified by their protein or gene expression profiles, the use of in vitro functional assays to determine their suppressive capacity is important to further characterize these cells. Here we present methods for the identification and purification of Tfr from both mice and humans followed by co‐culture with B cells and T follicular helper cells (Tfh). The suppressive activity of the Tfr is then assessed by the ability to prevent Tfh‐dependent B cell class switching and plasma blast formation measured by flow cytometry and immunoglobulin production in culture supernatants measured by enzyme‐linked immunosorbent assay. These assays will also provide in‐depth characterization of the functional suppressive capacity of any isolated Tfr or Treg population. © 2021 Wiley Periodicals LLC.Basic Protocol 1: Isolation of murine T follicular regulatory cellsBasic Protocol 2: Measurement of murine T follicular regulatory cell suppressive functionBasic Protocol 3: Isolation of human T follicular regulatory cellsBasic Protocol 4: Measurement of human T follicular regulatory cell suppressive function
Development of a Sensor Based on Poly(1,2‐diaminoanthraquinone) for Individual and Simultaneous Determination of Mercury (II) and Bismuth (III)
Authors: Shalaby E. A. , Beltagi A. M. , Hathoot A. A. , Azzem M. Abdel 
Published: November 2021

AbstractContamination of natural water by mercury (Hg2+) and bismuth (Bi3+) metal ions have been extensively studied due to their toxic effects. A validated square‐wave anodic stripping voltammetry (SW‐ASV) method for determining Bi3+ and Hg2+ ions individually and simultaneously is described. A new electrochemical sensor was constructed using a gold (Au) electrode that has been modified with poly(1,2‐diaminoanthraquinone) (p‐1,2‐DAAQ). Scanning electron microscopy, cyclic voltammetry, and electrochemical impedance spectroscopy were used to characterize the p‐1,2‐DAAQ/Au modified electrode. Factors such as the polymer film thickness, electrolyte, square wave parameters and preconcentration conditions were optimized to improve the performance of the modified Au electrode. Good linear responses were achieved in the concentration ranges of 1–200 μg L−1 and 1–50 μg L−1 forBi3+ and Hg2+, respectively, and the limits of detection were 0.27 μg L−1 (Bi3+) and 0.29 μg L−1 (Hg2+). The interference study results illustrated the high selectivity of the modified electrode for detection of Bi3+ and Hg2+. The proposed SW‐ASV method was successfully applied for Bi3+ and Hg2+analyses in different real water samples.