bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphological Changes in the Somatosensory Cortex of Guinea Pigs Following Simulation of the Abdominal Surgery Wound
Authors: Ishunina T. A. 
Published: December 2021

The aim of research was to study the effect of the abdominal wall injuries and ascorbic acid (AA) on morphometric parameters of the somatosensory cortex.Material and methods. The density of the arrangement of neurons, sizes of nuclei and perikaryons of neurons, density and area of blood vessels in the somatosensory cortex were detected in guinea pigs after simulation of the abdominal wall injury. The process was accompanied by the parenteral administration of AA.Results. Simulation of the abdominal wall injury in guinea pigs resulted in a decreased thickness of the somatosensory cortex and a decreased density of neurons arrangement (on average by 32-37%). In 7 days after the operation, the exposed animals demonstrated a decreased density of blood vessels by 14–18%, the size of blood vessels also decreased by 27–46%; the fact evidencing a deterioration in the blood supply to the somatosensory cortex in the postoperative period. The effect of AA was mainly manifested in the increased size of the nuclei and perikaryons of neurons (by 20–40%); this evidencing activation of their metabolic activity. The most significant changes in the studied parameters were observed in the outer granular and, to a lesser extent, in the pyramidal and inner granular cytoarchitectonic layers.Conclusion. Experimental abdominal surgical interventions resulted in a decreased size and density of blood vessels in the somatosensory cortex. The results obtained can be used to develop methods of postoperative rehabilitation with the inclusion of drugs that improve blood supply and metabolism of the brain neurons. AA potentiates some of the effects of surgery on the somatosensory cortex; currently, there are no sufficient data to recommend it as a neuroprotective agent in the postoperative period.
Frank Knight, Max Weber, la economía de Chicago y el institucionalismo
Authors: Emmett Ross 
Published: December 2021

Este ensayo muestra la influencia de Max Weber en el interés de Frank Knight por combinar la teoría económica y la historia económica comparada. En el periodo de entreguerras –cuando la enseñanza de la economía tenía un carácter pluralista– Knight se opuso al institucionalismo y defendió el estatus científico de la teoría neoclásica, pero sus lecturas de Weber Knight lo llevaron a considerar que el equilibrio y la competencia perfecta eran “tipos ideales”, construcciones útiles para la teorización pero que nunca se observan en la realidad. Ayudan a identificar los elementos centrales, pero el estudio de cómo cambian no es objeto de la teoría. Se debe recurrir entonces a la historia, en la que los cambios no se asemejan a equilibrios. En la posguerra apareció un nuevo estándar científico, que redefinió la disciplina y relegó la obra de Knight al ámbito no científico de la “filosofía social”.
MODEL MATEMATIKA KANKER NASOFARING DENGAN RADIOTERAPI
Authors: Syafii Maulan Aziz , Adi Yudi Ari 
Published: December 2021

Karsinoma nasofaring merupakan keganasan pada kepala dan leher yang terletak di nasofaring. Penyakit ini ditandai oleh serangkaian fitur geografis, etiologis dan biologis yang unik yang berbeda dari kanker kepala dan leher lainnya. Lanskap molekuler kanker nasofaring ditentukan oleh serangkaian variasi epigenetik genetik dan familial dan somatik, yang sebagian besar kanker nasofaring bercampur dengan infeksi virus Epstein-Barr (EBV) laten menghasilkan fenotipe ganas. Ada beberapa cara untuk mengobati kanker nasofaring, salah satunya adalah radioterapi. Penelitian ini akan membentuk model matematis empat persamaan diferensial biasa dengan empat variabel. Analisis stabilitas dalam penelitian ini adalah mempelajari suatu sistem dengan tujuan untuk mengetahui bentuk kestabilan titik-titik kesetimbangan pada masing-masing komponen titik kesetimbangan dalam model, sehingga dapat diketahui kapan komponenn titik-titik ekuibrium dari populasi sel laten, populasi sel yang terinfeksi, populasi invasif karsinoma, dan konsentrasi Radioterapi mencapai titik penyembuhan. Hasil penelitian menunjukkan dua titik kesetimbangan yaitu titik kesetimbangan bebas penyakit dengan dan titik ekuilibrium endemik untuk kanker nasofaring dengan memberikan dosis tertentu.
ANALISIS REGRESI COUNT DATA UNTUK PEMODELAN JUMLAH KASUS PENYAKIT TUBERKULOSIS DI KABUPATEN BANYUMAS
Authors: Kristy Kristy , Jajang Jajang , Nurhayati Nunung 
Published: December 2021

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Banyumas Regency is one of the districts with quite high Tuberculosis cases in Central Java. This study aims to analyze the factors that affect the number of tuberculosis cases in Banyumas Regency using regression analysis of count data. Poisson regression is the simplest count data regression model that has the assumption of equidispersion, that is, the mean value equal to the variance. However, in its application, these assumption is often not fulfilled, for example, there are cases of overdispersion (variance value is greater than the mean). In this study, to overcome the case of overdispersion, an approach was used using Generalized Poisson Regression (GPR) and negative binomial regression. The results showed that the data on the number of tuberculosis cases in Banyumas Regency in 2019 was overdispersion. The data modeling of the number of tuberculosis cases in Banyumas Regency with the negative binomial regression model is better than the GPR model. Meanwhile, the only predictor variable that affects the number of tuberculosis cases in Banyumas Regency is the sex ratio of productive age (15-49 years).
PENYELESAIAN PERSAMAAN POISSON MENGGUNAKAN METODE HOMOTOPI PERTUBASI
Authors: Mashuri Mashuri , Rahmi Sulistiowati Nur , Wijayanti Marwah Daud , Putri Alviana Pratama 
Published: December 2021

In this paper, we discuss the solution of the Poisson equation with some initial condition. We use the homotopy pertubation method to get the solution.. The homotopy pertubation method is a combination of the homotopy method and the pertubation method. The solution of the equation is assumed to be in the form of a power series. The result is by using the homotopy pertubation method for the diffution equation, the solution is the same with the exact solution.
Decision Support System For Energy Source Selection Based On Credibility Fuzzy Information.
Authors: Abdullah Saleem , Yahya Muhammad 
Published: December 2021

Abstract
This main objective of this work is to define some new operations of credibility fuzzy numbers using Hamacher t-norm and t-conorm. These operation are more generalized operation for credibility fuzzy numnbers, we apply these operations to aggregation operators for credibility fuzzy numbers. Furthermore, using the basic operational laws of Hamacher t-norm and t-conorm, we develop a series of credibility fuzzy Hamacher aggregation operators like credibility fuzzy Hamacher weighted averaging (CFHWA) and credibility fuzzy Hamacher geometric (CFHWG) aggregation operators. we also explained some of the proposed Hamacher aggregation operators properties like commutativity, idempotency and monotonicity. In order to validate the proposed Hamacher aggregation operators for credibility fuzzy numbers, we develop general algorithm for decision making technique under credibility fuzzy numbers and using these operators. The proposed algorithm is apply to electricity crises in Pakistan problems. Finally a comparison with other existing methods is done to check the accuracy and validation of the proposed methods. At rest the proposed method is verified by other well known methods.
Invasion in An Omnivorous Food Web: The Impact of Roles and Different Trophic Levels
Authors: Jiabu Duojie , Li Weide 
Published: December 2021

Abstract
In the field of ecology, habitat loss and fragmentation are the two main characteristic forms of habitat destruction and the main drivers of species extinction, resulting in the gradual loss of biodiversity. So far, many scholars have made some progress in the theoretical research of the spatial food web, but research on the effect of introducing an invasive species in an omnivorous food web is very rare. In order to explore the impact of invader on the persistence of species in omnivorous food webs, we constructed a model framework to describe the patch occupation of each species in omnivorous systems. Our model results show that invasive species is a prey of species in omnivorous food webs is easier to invade than invasive species is a predator of species in original omnivorous food webs on habitat loss and fragmentation. One conclusion also can be drawn is that when an invasive species is a prey of species in omnivorous food webs, no matter what trophic level the invasive species is invade, it is more successful. But when invasive species is a predator of species in different trophic levels on omnivorous food webs, they show different coexistence patterns. The invasion of a species has little effect upon the stability of original omnivorous food web for habitat loss and fragmentation, and will only make the original omnivorous food web more stable and more complicated. Therefore, we have proved that the omnivorous food web is stable and is not easy to destroy this ecological fact. Some examples to illustrate the reliability of our model results are discussed.
Reduced rice paddy methane emission through dual compound mechanism in novel cultivars
Authors: Jin Yunkai , Liu Tong , Hu Jia , Sun Kai , Xue Lihong , Bettembourg Mathilde , Hou Pengfu , Hao Peiyinh , Tang Jintian , Ye Zihoung , Liu Chunlin , Li Peng , Pan Aihu , Wang Lushui Wang , Xiao Guoying , Moazzami Ali , Yu Xiaoping , Schnürer Anna , Sun Chunaxin 
Published: December 2021

Abstract
Methane is the second most abundant greenhouse gas after carbon dioxide and its concentrations have risen tenfold in the past decade due to agricultural activity1. Rice paddies are considered a major source of anthropogenic methane, however strategies to mitigate methane emission in rice paddies is not yet successful despite considerable efforts being made. Methane production is caused by microbial communities feeding on organic exudates from the rice root, and regulation of the dominant secretions has been suggested as leading way to put an end to the methane emission from rice paddies. Here, we introduced a new system to reduce methane emission in rice paddies based on the discovery that fumarate and ethanol are two specific rice-orchestrated compounds that determine the levels of methane emission from rice paddies. Moreover, stable low-fumarate high-ethanol secretion lines have been successively bred through hybrid breeding and shown to cut around 70% of methane emission in paddies as compared to control. Approaches to block fumarate reductase or increase ethanol level, were furthermore employed as cultivation managements and resulted in a reduction in methane emissions of around 60%, calculated from two-year four-site field work. All results highlight the application of our findings to largely mitigate influences of rice cultivation on global climate.
Many-body localization enables iterative quantum optimization
Authors: Wang Hanteng , Yeh Hsiu-Chung , Kamenev Alex 
Published: December 2021

Abstract
We suggest an iterative quantum protocol, allowing to solve optimization problems with a glassy energy landscape. It is based on a periodic cycling around the tricritical point of the many-body localization transition. This ensures that each iteration leads to a non-exponentially small probability to find a lower local energy minimum. The other key ingredient is to tailor the cycle parameters to a currently achieved optimal state (the "reference" state) and to reset them once a deeper minimum is found. We show that, if the position of the tricritical point is known, the algorithm allows to approach the absolute minimum with any given precision in a polynomial time.
The Effect of IL-6-Primed Platelets on ADAMTS13-Mediated Clearance of Platelet-Bearing ULVWF and Its Mechanism
Authors: Kim Hyun-Jeong , Dong Jing-fei , Song Yejin , Jung Hyo-Il , Song Jaewoo 
Published: December 2021

Abstract
Inflammation is an essential contributing factor in the development of thrombosis. Using a microfluidic flow chamber, we investigated how the proinflammatory cytokine interleukin 6 (IL-6) affects the cleavage of platelet-bearing ultra-large VWF (ULVWF) by plasma ADAMTS13. We found that IL-6-treated platelets perfused at arteriolar shear stress significantly enhanced the ULVWF-platelet complex formation on activated endothelial cells and suppressed their clearance by ADAMTS13 under flow conditions. We also detected the phosphorylation of the serine/threonine kinase Akt and extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) in platelets treated with IL-6. Treatment of IL-6-primed platelets with either the phosphoinositol-3 kinase (PI3K) inhibitor LY294002 or the mitogen-activated protein kinase kinase (MEK) inhibitor U0126 reduced the ULVWF-platelet complex formation and restored the clearance of the complex by plasma ADAMTS13, compared to IL-6-primed platelets. Furthermore, IL-6 enhanced the phosphorylation of the intracellular adaptor molecule 14-3-3ζ, which regulates VWF binding to the glycoprotein (GP) Ib-IX complex. The 14-3-3 antagonist R18 significantly increased ADAMTS-13 cleavage of ULVWF strings with adherent IL-6-treated platelets. These findings indicate that IL-6 related intracellular signals of platelet is involved in regulating ULVWF-platelet binding and ULVWF cleavage by ADAMTS13.
miR-199b-3p Promotes Radiation-induced Oral Mucositis via DDIT4-mediated mTOR Signal Pathway
Authors: Yang Jiantang , Fu Lili , Zeng Yi , Yuan Chen 
Published: December 2021

Abstract
Background: Radiation-induced oral mucositis (RIOM) is an adverse reaction in patients of head and neck cancer after radiotherapy. However, the key regulatory factors in the pathogenesis of RIOM remain largely unclear. In this article, we discover a novel role of DNA damage-inducible transcript 4 (DDIT4) in regulating RIOM pathogenesis.Methods: We established RIOM in vitro and in vivo models to mimic the biological processes of RIOM. The level of DDIT4 in RIOM was analyzed by real-time PCR and Western blot. Through the bioinformatics analysis and luciferase assay, the relationship between miR-199b-3p and DDIT4 was performed. The level of mTOR signaling were explored by Western blot. Besides, Clone Formation and EDU assay were performed to investigate the effects of miR-199b-3p/DDIT4 on cell proliferation. H&E and immunohistochemistry experiments examined the effects of miR-199b-3p/DDIT4 on RIOM in vivo. Results: We found that the level of DDIT4 was significantly reduced during the RIOM formation, and up-regulated of DDIT4 suppressed the progression of RIOM in vitro and in vivo. Besides, we found DDIT4 was a direct target of miR-199b-3p. Ectopic expression of miR-199b-3p repressed the level of DDIT4 and activated mTOR signal conduction to promote RIOM progress, whereas the silencing of miR-199b-3p promoted the DDIT4-mediated RIOM regulation both in vitro and in vivo. Conclusion: Collectively, our studies not only identified the novel functional role of DDIT4 in modulating pathogenic processes of RIOM but also provided new directions and ideas for the future treatment of radiotherapy oral mucositis.
Effect of Solid-State Fermentation on the essential oil yield of Curcuma longa residues
Authors: Boum Alexandre Teplaira , Kwanga Sylvie Nguikwie , Tegoundio Doriane , Anoh Felix Adje 
Published: December 2021

Abstract
The solid waste of Curcuma longa rhizomes generated after its cold juice process making is mostly unused and discarded even though they can contain essential oil. Conventional techniques such as hydrodistillation can be used to extract essential oil, but this generally results in low essential oil yield and inefficient extraction time. Solid-state fermentation as a pretreatment of distillation could improve the yield of essential oil. In this study, we evaluated the effect of solid state fermentation on the yield of extraction of Curcuma longa solid wastes essential oil. The solid-state fermentation was carried out naturally without any addition of inoculum and the extraction was performed by hydrodistillation. Under experimental conditions at room temperature and anaerobically in the dark, the treatment of 7 days of solid state fermentation followed by 2h of hydrodistillation provided the highest yield of 1.21% as compared to non-fermented of 0.35% and of 0.96% relative to the raw plant material representing an increase of 71% and 21% respectively. A
Regional Parameters for Human Health Impact Assessment
Authors: Belyanovskaya Alexandra , Soktoev Bulat , Laratte Bertrand , Ageeva Elena , Baranovksaya Natalia , Korogod Natalia 
Published: December 2021

Abstract
The research paper is aimed to modify the human health impact assessment of Cr in soils. The current article presents the input of several critical parameters for the human health Impact Score (IShum) assessment in soils. The modification of the IShum is derived using geological data (results of neutron activation analysis of soils are used in the IShum calculation; research area is divided using the watersheds) and population size and density. Watersheds reflect the local environmental conditions of the territory unlike the administrative units due to their geological independence. The calculations of the Characterization factor value underestimate the influence of the population size and density on the final result. Default regional values cannot be considered during the assessment of the potential human health impact for the big sparsely inhabited areas. In case of very low population density the result will be overrated and underestimated in the opposite case. The current approach demonstrates the generosity of the geographical separation in the USEtox model. The same approach can be utilized for other geo zones due to the accessibility of this information (area size, population size and density, geological and landscape features).
Chemical and Behavioural Strategies along The Spectrum of Host Specificity in Ant-Associated Silverfish
Authors: Parmentier Thomas , Gaju-Ricart Miquel , Wenseleers Tom , Molero-Baltanás Rafael 
Published: December 2021

Abstract
Background
Host range is a fundamental trait to understand the ecological and evolutionary dynamics of symbionts. Increasing host specificity is expected to be accompanied with specialization in different symbiont traits. We tested this specificity-specialization association in a large group of 16 ant-associated silverfish species by linking their level of host specificity with their degree of behavioural integration into the colony and their accuracy of chemically deceiving the host’s recognition system, i.e. the cuticular hydrocarbon (CHC) profile.
Results
As expected, facultative associates and host generalists (targeting multiple unrelated ants) tend to avoid the host, whereas host-specialists (typically restricted to Messor ants) were bolder, approached the host and allowed inspection. Generalists and host specialists regularly followed a host worker, unlike the other silverfish. Host aggression was extremely high toward non-ant-associated silverfish and modest to low in ant-associated groups. Surprisingly, the degree of chemical deception was not linked with host specificity as most silverfish, including facultative ant associates, imitated the host’s CHC profile. Messor specialists retained the same CHC profile as the host after moulting, in contrast to a host generalist, suggesting an active production of the cues (chemical mimicry). Host generalist and facultative associates flexibly copied the highly different CHC profiles of alternative host species, pointing at passive acquisition (chemical camouflage) of the host’s odour.
Conclusions
Overall, we found that behaviour that seems to facilitate the integration in the host colony was more pronounced in host specialist silverfish. Chemical deception, however, was employed by all ant-associated species, irrespective of their degree of host specificity.
Complex regulation of Gephyrin splicing is a determinant of inhibitory postsynaptic diversity
Authors: Reis Raphael Dos , Kornobis Etienne , Pereira Alyssa , Tores Frédéric , Carrasco Judit , Jahannault-Talignani Céline , Nitschké Patrick , Muchardt Christian , Schlosser Andreas , Maric Hans , Ango Fabrice , Allemand Eric 
Published: December 2021

Abstract
Gephyrin (GPHN) regulates the clustering of postsynaptic components at inhibitory synapses and is involved in pathophysiology of neuropsychiatric disorders. Here, we uncover an extensive diversity of GPHN transcripts that are tightly controlled by splicing during mouse and human brain development. Proteomic analysis reveals at least a hundred isoforms of GPHN incorporated at inhibitory Glycine and GABA-A receptors containing synapses. They exhibit different localization and postsynaptic clustering properties, and altering the expression level of one isoform is sufficient to affect the number, size, and density of inhibitory synapses in cerebellar Purkinje cells. Furthermore, we discovered that splicing defects reported in neuropsychiatric disorders are carried by multiple alternative GPHN transcripts, demonstrating the need for a thorough analysis of the GPHN transcriptome in patients. Overall, we show that alternative splicing of GPHN is an important genetic variation to consider in neurological diseases and a determinant of the diversity of postsynaptic inhibitory synapses.
Evaluation of Biological Effect in Breast Cell Irradiated with Dose 2 Gy in Radiotherapy
Authors: Pereira Leslie , Lima Antonio Gilcler F. , Ferreira Marcella T. , Salata Camila , Ferreira-Machado Samara C , Morandi Veronica , Magalhães Luis Alexandre Gonçalves 
Published: December 2021

Abstract
Introduction: Breast cancer (BC) is the most common female malignancy worldwide. For the definitive treatment of MC, radiotherapy can be used, as an important component, and uses ionizing radiation (IR). Studies reveal the potential capacity of IR to promote metastasis. The clinical response of BC to radiotherapy is related to radiosensitivity and resistance of irradiated cells, which is associated with clonogenic activity and sensitivity to radiation. Unsuccessful treatment increases the risk of local and distant recurrence.Methodology: Three breast cell lines (MCF-10A, MCF-7, and MDA-MB-231) were irradiated with 2 Gy and after 72 hours following markers were evaluated: E-cadherin, fibronectin, vimentin, and Snail. The processes of invasion, degradation of MMP2 and MMP9, and transendothelial migration were then assessed. Double-strand DNA breaks (DSBs), apoptosis, and colony formation were quantified. Result: The detection of γH2AX histone of irradiated cells showed that MCF-10A non-tumor cell is more radiosensitive while the MDA-MB-231 tumor cell is more radioresistant. The dose 2 Gy altered the formation of colonies to any of the cell lines. Tumorigenic cells exhibited a markedly increase in apoptosis, 24 h after irradiation while MCF-10A cells only after 72 h. A single dose of 2 Gy does not induce changes in the cellular microenvironment that lead to changes in the mesenchymal epithelium in breast BC.Conclusion: A dose of 2 Gy induces apoptosis and consequently an alteration in cell survival. However, a single dose of 2 Gy does not induce changes in the cellular microenvironment that lead to changes in the mesenchymal epithelium.