bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic Management of VA-ECMO Support for Cardiogenic Shock: Case Report.
Authors: Yang Hongfeng , Yan Jun , Yu Zhixin , Cai Yan , Jin Zhaochen 
Published: July 2021

Abstract
Introduction: Cardiogenic shock is considered a serious stage of heart disease, and there is no better way to treat this. Veno-arterial Extracorporeal membrane oxygenation (VA-ECMO) is a well-established technology that can be used as potential life-saving measures in patients who present with cardiac arrest or severe hemodynamic instability by improving organ perfusion and oxygenation. However, it is usually complex and needs individualized decisions in a multidisciplinary approach to manage patients receiving Extracorporeal membrane oxygenation, as defined clinical condition’s protocols are still lacking. Case presentation: one patient was a 44-year-old man with out-of-hospital ventricular fibrillation was transferred to our hospital after initial cardiopulmonary resuscitation. In the emergency department, he presented with ST-segment elevation extensive anterior wall myocardial infarction and cardiogenic shock with paroxysmal ventricular tachycardia. After transfer to intensive care unit, VA-ECMO was implanted due to worsening cardiogenic shock and recovered slowly thereafter. Another patient was a 58-year-old woman presented refractory hypotension. As a bridge-therapy, VA-ECMO support was implanted and then the patient was taken to the cardiac catheterization laboratory where she experienced Percutaneous coronary intervention and implanted a drug-eluting stent in the right coronary artery. Due to acute kidney injury, continuous renal replacement therapy was given to facilitate the control of fluid access balance, the removal of inflammatory media.Conclusion: VA-ECMO is not only used as a temporary treatment strategy for cardiogenic shock, but also as a bridge-therapy. It is important to focus on the improve the success rate of VA-ECMO treatment and avoid complications.
A Pilot Study of Ponatinib in Patients With FGFR-Altered Advanced Cholangiocarcinoma
Authors: Ahn Daniel H. , Junior Pedro Luiz Serrano Uson , Masci Peter , Kosiorek Heidi , Halfdanarson Thorvardur R. , Mody Kabir , Babiker Hani , DeLeon Thomas , Sonbol Mohamad Bassam , Gores Gregory , Smoot Rory , Bekaii-Saab Tanios , Mahipal Amit , Mansfield Aaron , Tran Nguyen H , Hubbard Joleen M , Borad Mitesh J. 
Published: July 2021

Abstract
Background:Biliary tract cancers (BTC) are rare, chemo resistant and are associated with a poor prognosis. Preclinical and early clinical work had demonstrated interesting anti-tumor activity from targeting fibroblast growth factor receptor (FGFR) pathway. We hypothesized that ponatinib, a multi-targeted tyrosine kinase inhibitor with activity against FGFR, would be active in BTC patients with FGFR alterations.Methods:This was a multi-center, single institution pilot study of ponatinib in patients with advanced, refractory BTC with FGFR alterations. The primary end point was overall response rate, with secondary points of overall survival (OS), progression-free survival (PFS) and Health Related Quality of Life (HRQoL) assessment. Results:Twelve patients were enrolled prior to early termination of the trial. Clinical benefit (defined as complete/partial response + stable disease) of 45.5% was observed. All observed toxicities were manageable and reversible. Toxicities were mild, with lymphopenia (75%), rash (63%) and fatigue (50%) being the most frequent. No significant detriment in global QoL was observed.Conclusions:Ponatinib as a single agent in FGFR altered BTC is tolerable with very modest clinical activity. This is the first report of prospective assessment of FGFR inhibition in BTC using ponatinib, and the first study to report its effect on HRQoL. Further development of ponatinib will involve correlative studies to better refine patient selection, focus on combinations with other molecular targeted agents, conventional cytotoxic chemotherapy, and studies to better understand mechanisms of treatment resistance.
Measurement-based Investigation of the DC and RF Transconductance for Various HEMT Technologies in High-and Low-temperature Conditions
Authors: Alim Mohammad Abdul , Jarndal Anwar , Gaquiere Christophe , Crupi Giovanni 
Published: July 2021

Abstract
The purpose of this experimental study is to evaluate quantitatively the impact of the temperature on the behavior of various high electron-mobility transistor (HEMT) technologies through the analysis of the DC and RF transconductance. The experimental data are reported for six different HEMT devices, in order to develop a comparative analysis based on various technologies, including gallium arsenide (GaAs) and gallium nitride (GaN) materials, matched and pseudomorphic HEMTs, single- (S-H) and double-heterojunction (D-H) HEMTs, and both virgin and multi-layer devices. The reported findings show that the impact of the ambient temperature on the HEMT behavior strongly depend on the tested technology and operating conditions. As a matter of fact, a higher temperature can lead to increased or degraded transconductance, depending on the device technologies and bias point. In the GaAs-based devices, an operating bias condition at which the DC and RF transconductance are temperature insensitive can be defined, owing to two-opposite temperature-dependent effects counteracting with each other.
A CpGs Methylation Signature as Potential Marker for Early Diagnosis of Hepatocellular Carcinoma from HBV-Related Liver Disease using Multiplex Bisulfite Sequencing
Authors: Li Kang , Song Yi , Qin Ling , Li Ang , Jiang Sanjie , Ren Lei , Zang Chaoran , Sun Jianping , Zhao Yan , Zhang Yonghong 
Published: July 2021

Abstract
Background: Aberrant methylation of CpG sites severed as epigenetic marker for building diagnostic, prognostic, and recurrence models for hepatocellular carcinoma (HCC). Methods:Using Illumina 450K and EPIC Beadchip, we identified 34 CpG sites in peripheral blood mononuclear cell(PBMC) DNA that were differentially methylatedin early HCCversusHBV-related liver diseases (HBVLD). We employed multiplex bisulfite sequencing (MBS) based onnext-generation sequencing (NGS) to measure methylation of 34 CpG sites in PBMC DNA from 654 patients that were divided into a training set (n = 442), a test set (n = 212). Using training set, we selected and built a six-CpG-scorer (including cg14171514, cg07721852, cg05166871, cg18087306, cg05213896, and cg18772205), applying least absolute shrinkage and selection operator (LASSO) regression. We performed multivariable analyses of four candidate risk predictors (including six-CpG-scorer, age, sex, AFP level), using 20 times imputation of missing data, non-linearly transformed and backwards feature selection with logistic regression. The final model’s regression coefficients were calculated according to “Rubin's Rules”. The diagnostic accuracy of model was internally validated with10000 bootstrap validation dataset, and then applied to thetest set for validation.Results:The area under the receiver operating characteristic curve (AUROC) of the model was 0.81(95%CI, 0.77-0.85) and it showed good calibration, decision curve analysis. Using enhanced bootstrap validation, adjusted C-statistics and adjusted brier score was 0.809 and 0.199, respectively. The model also showed AUROC value of 0.84 (95% CI 0.79-0.88) of diagnosis for early HCC in test set.Conclusions:Our model basing onsix-CpG-scorer was a reliable diagnosis tool for early HCC from HBVLD.The usage of MBS method can realize large-scale detection of CpGsites in clinical diagnosis of early HCCand benefit the majority of patients.
Athletic Trainers’ Viewpoints of Patient-Centered Care
Authors: Wilson Carly J. , Eberman Lindsey E. , Redinger Ansley S. , Neil Elizabeth R. , Winkelmann Zachary K. 
Published: July 2021

Abstract
Background

The core competency of patient-centered care (PCC) states that for positive patient outcomes, the provider must respect the patient’s views and recognize their experiences. The Athletic Training Strategic Alliance Research Agenda Task Force identified a profession-wide belief that examining the extent to which athletic trainers (ATs) provide PCC in their clinical practice would benefit the profession. To first address this line of inquiry, we must study the subjectivity of how ATs view PCC.
Methods

We used Q methodology to allow participants to share their viewpoints while simultaneously exploring the study aim from a quantitative and qualitative perspective. A total of 115 (males = 62, females = 53, age = 37 ± 10 y, experience = 13 ± 10 y) ATs dispersed between 11 job settings volunteered for this study. Participants were asked to pre-sort (agree, disagree, neutral) 36 validated statements representing the 8 dimensions of PCC. The participants completed a Q-sort where they dragged-and-dropped the pre-sorted statements based on perceived importance in providing PCC. The Q-sorts were analyzed using QMethod software. A principal component analysis was used to identify statement rankings and factors. Factors were determined by an Eigenvalue > 1 and analyzed using a scree plot. The 6 highest selected statements per factor were assessed to create the distinguishing viewpoints.
Results

Two distinguishing viewpoints emerged from the Q-sorts. The statement “ATs treat patients with dignity and respect” appeared as a high ranked statement in both distinguishing viewpoints. The lowest ranked statement from viewpoint 1 was “ATs integrate the International Classification of Functioning, Disability, and Health (ICF) model as a framework for delivery of patient care.” The lowest ranked statement from viewpoint 2 was “Appointment scheduling is easy.”
Conclusions

ATs value patient’s preferences. However, a lack of importance was identified for incorporating the ICF model, which is a core competency and adopted framework by the NATA since 2015.
Human DNA AI Model to Predict COVID-19 Symptomatic or Asymptomatic Percentages
Authors: Martinez Peter Oropeza , Rosas-Vargas Haydeé , Gaggero-Sager Luis 
Published: July 2021

Abstract
The current paper proposes to use convolutional neural networks (CNN) to analyze human genome single nucleotide variants (SNVs) from nuclear deoxyribonucleic acid (DNA) and
mitochondrial deoxyribonucleic acid (mtDNA) presented as a 2D image structure to understand if the answer to COVID-19 severities can be found in the human genome. That methodology was implemented with 447 Mexican population samples. From the results, two main groups were formed divided into symptomatic and asymptomatic cases composed of 80.986% and 19.014% respectively and the model was validated through an online survey of individuals, giving a 91.89% of accuracy.
Ethamsylate attenuates mutilated secondary pathogenesis and exhibits a neuroprotective role in experimental model of spinal cord injury
Authors: Dolma Sonam , Adhikari Kirti , Mamidi Teena , Roy Abhishek , Pathak Zarna , Kumar Hemant 
Published: July 2021

Abstract
Deficits in the neuronal connection that succumbs to the impairment of sensory and motor neurons are the hallmarks of spinal cord injury (SCI). Secondary pathogenesis, which initiates after the primary mechanical insult to the spinal cord, depicts a pivotal role in producing inflammation, lesion formation and ultimately causes fibrotic scar formation in the chronic period. This fibrotic scar formed acts as a major hindrance in facilitating axonal regeneration and is one of the root causes of motor impairment. Cascade of secondary events in SCI begins with injury-induced blood spinal cord barrier rupture that promotes increased migration of neutrophils, macrophages, and other inflammatory cells at the injury site to initiate the secondary damages. This phenomenon leads to the release of matrix metalloproteinase, cytokines and chemokines, reactive oxygen species, and other proteolytic enzymes at the lesion site. These factors assist in the activation of TGF-β1 signalling pathway, which further leads to excessive proliferation of perivascular fibroblast, followed by deposition of collagen and fibronectin matrix, which are the main components of the fibrotic scar. Subsequently, this scar formed inhibits the propagation of action potential from one neuron to adjacent neurons. Ethamsylate, an anti-hemorrhagic drug, has the potential to maintain early hemostasis as well as restores capillary resistance. Therefore, we hypothesized that ethamsylate, by virtue of its anti-hemorrhagic activity, reduces hemorrhagic ischemia-induced neuronal apoptosis, maintains the blood spinal cord barrier integrity, and decreases secondary damage severity, thereby reduce the extent of fibrotic scar formation, and demonstrates a neuroprotective role in SCI.
The Topographic Representation of Time and its Link with Temporal Context and Perception
Authors: Kulashekhar Shrikanth , Maass Sarah , Rijn Hedderik Van , Bueti Domenica 
Published: July 2021

Abstract
Neuronal tuning and topography are mechanisms widely used in the brain to represent not only sensory information but also abstract features like numerosity and time. In humans, temporal topography has been shown recently in a wide circuit of brain regions, from lateral occipital to inferior parietal and premotor regions. However, it remains unclear whether chronotopic maps are specific to vision, whether they map time in an absolute or relative fashion, and to what extent they reflect objective or subjective, perceived time and whether they are influenced by temporal context. Here we asked human participants to reproduce the durations of sounds in two, partially overlapping, temporal contexts while we recorded high-spatial resolution fMRI. Both model-based and data driven analysis approaches show the presence of auditory chronomaps in the auditory parabelt, intraparietal sulcus, and in the supplementary motor area (SMA). Most importantly, when the same physical duration is presented in different temporal contexts, and thus perceived differently, different neuronal units respond to it. Those units were also spatially shifted on the cortical surface according to the relative position of the perceived duration within each context. Finally, voxels did not change their preferences across contexts and their pattern of activity was more similar within rather than across them, suggesting a pivotal role of the context in shaping the maps. These results highlight two important properties of human chronomaps: their flexibility of representation due to perception and their dependency on temporal context.
Host traits and evolution shape key coral-bacterial symbioses
Authors: Ricci Francesco , Tandon Kshitij , Black Jay , Cao Kim-Ahn Lê , Blackall Linda , Verbruggen Heroen 
Published: July 2021

Abstract
The success of tropical scleractinian corals depends on their ability to establish symbioses with microbial partners. Host traits and evolution are known to shape the coral microbiome, but to what extent they affect its composition remains unclear. Here, by using twelve coral species representing the complex and robust clades, we show that functional traits and host evolutionary history explain 14% of the tissue and 13% of the skeletal microbiome composition, providing evidence that these predictors contribute to shaping the holobiont in terms of the presence and abundance of key bacterial species. Additionally, our study shows that the coral tissue and skeleton are dominated by rare bacteria and the skeleton can function as a microbial reservoir. Together, we provide novel insights into the processes driving coral-bacterial symbioses along with an improved understanding of the scleractinian tissue and skeleton microbiome.
Selected ‘Starter Kit’ energy system modelling data for Cambodia (#CCG)
Authors: Allington Lucy , Cannone Carla , Pappis Ioannis , Barron Karla Cervantes , Usher Will , Pye Steve , Brown Edward , Howells Mark , Walker Miriam Zachau , Ahsan Aniq , Charbonnier Flora , Halloran Claire , Hirmer Stephanie , Taliotis Constantinos , Sundin Caroline , Sridha Vignesh , Ramos Eunice , Brinkerink Maarten , Deane Paul , Gritsevskyi Andrii , Moura Gustavo , Rouget Arnaud , Wogan David , Barcelona Edito , Rogner Holger 
Published: July 2021

Abstract
Energy system modelling can be used to assess the implications of different scenarios and support improved policymaking. However, access to data is often a barrier to energy system modelling, causing delays. Therefore, this article provides data that can be used to create a simple zero order energy system model for Cambodia, which can act as a starting point for further model development and scenario analysis. The data are collected entirely from publicly available and accessible sources, including the websites and databases of international organizations, journal articles, and existing modelling studies. This means that the dataset can be easily updated based on the latest available information or more detailed and accurate local data. These data were also used to calibrate a simple energy system model using the Open Source Energy Modelling System (OSeMOSYS) and three stylized scenarios (Fossil Future, Least Cost and Net Zero by 2050) for 2020–2050. The assumptions used and results of these scenarios are presented in the appendix as an illustrative example of what can be done with these data. This simple model can be adapted and further developed by in-country analysts and academics, providing a platform for future work.
Few Canadian children and youth were meeting the 24-hour movement behaviour guidelines 6-months into the COVID-19 pandemic: Follow-up from a national study
Authors: Moore Sarah A , Faulkner Guy , Rhodes Ryan E , Vanderloo Leigh M , Ferguson Leah J , Guerrero Michelle D , Brussoni Mariana , Mitra Raktim , O’Reilly Norm , Spence John C , Chulak-Bozzer Tala , Tremblay Mark S 
Published: July 2021

Abstract
Daily life has changed for families due to the COVID-19 pandemic. The aim of this repeated cross-sectional study was to describe movement behaviours in Canadian children and youth six months into the pandemic (T2; October 2020) compared with the start of the pandemic (T1, April 2020). An online survey was distributed to parents (N = 1568) of children and/or youth (5–17 years; 58% girls) in October 2020. The survey assessed changes in movement behaviours [physical activity (PA) and play, sedentary behaviours (SB), and sleep] from before the pandemic to October 2020 (T2). We compared these data to spring data (T1; April 2020; Moore et al., 2020) collected using identical methodology (N = 1472; 54% girls). We report correlations between movement behaviours and relevant parental factors and provide word frequency distributions for open-ended responses. During the second wave, 4.5% of children (4.6% girls; 4.3% boys) and 1.9% of youth (1.3% girls, 2.4% boys) met the movement guidelines (3.1% overall). Whereas, during the first wave, 4.8% (2.8% girls, 6.5% boys) of children and 0.6% (0.8% girls, 0.5% boys) of youth were meeting combined guidelines (2.6% overall). Parental support was correlated with their child’s movement behaviours (T1 and T2). Our study demonstrates the ongoing challenges for children and youth to engage in healthy movement during the pandemic.
The Role of the Church in Efforts to Improve the Economy of Indigenous Peoples in Papua, Indonesia
Authors: Junaedi I Wayan Ruspendi , Waruwu Dermawan , Damayana I Wayan , Utama I Gusti Bagus Rai 
Published: July 2021

Abstract
The novelty of this research is to prove that the community has been unable to encourage and motivate entrepreneurship growth to improve the economy of indigenous peoples in Papua. This research was carried out in-depth in Papua using descriptive qualitative methods using extensive interviews, observations, and secondary data techniques. The results of the study show that the efforts of the Indonesian Christian Church in Papua to improve the economy of indigenous peoples at both synods, classical, and community levels are still small. The community is currently facing challenges internally and externally. You are grappling with the global Covid-19 pandemic situation. Internet problems still exist in many areas of Papua, making communication even more difficult. To improve the economy of the indigenous peoples, the community tries to implement a common empowerment strategy and strategic steps, namely an open heart-to-heart dialogue between all church components internally at different levels. What is required is a concrete problem mapping with a priority scale and the ability to implement strategic indigenous economic development programs, and supported by appropriate support according to the regional or usual context. At the same time, the community must prepare competent human resources in its areas for long-term economic development.
Differential impact of liana colonization on the leaf functional traits of co-occurring deciduous and evergreen trees
Authors: pandi vivek , Babu Kanda Naveen 
Published: July 2021

Abstract
The present study was carried out to analyse the leaf functional traits of co-occurring evergreen and deciduous tree species in a tropical dry scrub forest. This study also intended to check whether the species with contrasting leaf habits differ in their leaf trait plasticity, responding to the canopy-infestation by lianas. A total of 12 leaf functional traits were studied for eight tree species with contrasting leaf habits (evergreen and deciduous) and liana-colonization status (Liana+ and Liana−). In the liana-free environment (L−), evergreen trees had significantly higher specific leaf mass (LMA) and leaf dry matter content (LDMC) than the deciduous species. Whereas, the deciduous trees had higher specific leaf area (SLA) and mass-based leaf nitrogen concentration (Nmass). The leaf trait-pair relationship in the present study agreed to the well-established global trait-pair relationships (SLA Vs Nmass, Lth Vs SLA, Nmass Vs Lth, Nmass Vs LDMC, LDMC Vs SLA). There was no significant difference between L+ and L− individuals in any leaf functional traits studied in the deciduous species. However, evergreen species showed marked differences in the total chlorophyll content (Chlt), chlorophyll b (Chlb), SLA, and LMA between L+ and L− individuals of the same species. Deciduous species with the acquisitive strategy can have a competitive advantage over evergreen species in the exposed environment (L−) whereas, evergreen species with shade-tolerant properties were better acclimated to the shaded environments (L+). The result revealed the patterns of convergence and divergence in some of the leaf functional traits between evergreen and deciduous species. The results also showed the differential impact of liana colonization on the host trees with contrasting leaf habits. Therefore, liana colonization can significantly impact the C-fixation strategies of the host trees by altering their light environment. Further, the magnitude of such impact may vary among species of different leaf habits. The increased proliferation of lianas in the tropical forest canopies may pose a severe threat to the whole forest carbon assimilation rates.