bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic study of Anopheles gambiae s.l. population and polymorphism of TRP1 gene during high malaria transmission season in Bancoumana commune, Mali
Authors: Diallo Mouctar , Sangare Djibril , Diarra Assetou , Camara Djènèba , Mariko Ramata , Guidenhard Markus , Kopitz Hanne , Sandrina L , Coulibaly Djènèba , Coulibaly Boubacar , Sacko Adama , Traoré Sekou F. 
Published: August 2021

Malaria vector control strategy is a key component of malaria control, it can interrupt malaria transmission. The effective use of this strategy is based on a depth knowledge of vector life cycle and the environmental factors that influence its life. The aims of this study was to determine the dynamics of the adult population of An.gambiae s.l. and to evaluate the allelic polymorphism of TEP1 gene implicate in malaria parasite lysis. This was conducted in endemic malaria areas Nanguilabougou and its hamlet of culture Kouroubabougou in the rural commune of Bancoumana between June 2014 and November 2015 during the high malaria transmission season. Mosquitoes were collected using light traps, stored in 50-ml tubes containing ethanol 70%, processed in the laboratory using PCR (DNA extraction, species identification and genotyping). In 2014 a total of 1433 mosquitoes were collected, An coluzzii was predominant 72.2% (n= 1034) follow by An gambiae 21.1% and hybrid An coluzzii/gambiae 3.1%. The same situation was observed in 2015 with 6612 mosquitoes collected, An coluzzii 72.4% follow by An gambiae 16.7% and hybrid An. coluzzii/gambiae 0.4%. Two An. arabiensis were found only in 2015. A strong presence of the genotype R1/R1 within An. coluzzii 85.2% in 2014 and 66.2% in 2015 was observed. An. gambiae was more associated with the S1/S1 genotype in 2014 and with the S1/R2 allele in 2015. The other allele were founded at low frequency. An. coluzzii is the most predominant during high malaria transmission season among An. gambiae s.l. species. It is also carried the high frequency TEP1 gene implicate in malaria parasite lysis.
Identificação de formaldeído em produtos capilares: relato da transposição de uma aula prática para o modelo EAD-Em e seu impacto no ensino em cursos da área da saúde
Authors: Cunha Ana Cristina Borba , Jacques Pedro Henrique Mirapalheta , Schmidt Rita de Cássia dos Reis , Andrade Henrique Carvalho , Dutra Ângela de Mattos 
Published: August 2021

O presente estudo foi desenvolvido por meio de uma pesquisa aplicada na disciplina de química analítica na Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), RS. A questão norteadora da pesquisa teve por objetivo avaliar a compreensão dos discentes sobre o conteúdo elaborado originalmente para uma aula prática presencial, que foi adaptado ao formato de Ensino à Distância-Emergencial (EAD-Em), em função da pandemia de Sars-CoV-2 (COVID-19). A aula prática intitulada “Identificação de formaldeído (formol) em produtos capilares” foi selecionada para o estudo de caso. A transposição da aula prática para o formato EAD-Em ocorreu durante o ano de 2020 e 2021. Participaram do estudo 20 alunos matriculados na disciplina de química analítica. A coleta de dados ocorreu após a aplicação da metodologia no formato EAD-Em. Entre os dados coletados observou-se que 85% dos alunos consideraram proveitosa a estratégia utilizada para a realização da prática em EAD-Em e 95% afirmaram ter gostado de participar da atividade. Portanto concluiu-se que apesar dos desafios impostos pela pandemia é possível adaptar atividades práticas para o formato EAD-Em com impacto positivo sobre a adesão e aprendizagem dos alunos.
A Case of Acute Lead Toxicity Associated with Siddha Medication
Authors: Janardhanan Sandheep , James Allwin , Palaniappan Alagammai , Ardhanari Ramesh 
Published: August 2021

Siddha is an indigenous system of medicine practiced exclusively in South India.Some of these formulations have been postulated to cause heavy metal poisoning,like lead toxicity. Here we present a case of Siddha medicine induced lead toxicity causing intractable chronic abdominal pain.
Does Micro-Credit Lending to Small Scale Enterprises Stimulate Economic Advancement in Nigeria? Evidence from ARDL Analysis
Authors: Nwaogwugwu Chuks , Ihendinihu John U. 
Published: August 2021

The microfinance institutions are evident tools for Small Scale Enterprises development due to the roles they perform in the economic advancement. Past studies have shown microfinance serves as a key player in the financial sector that has positively impacted in all works of life through the services it offers. This study is positioned to explore the case of Nigeria by examining the impact of micro-credit lending to Small Scale Enterprises on economic advancement in Nigeria over the period 1992–2019, using the autoregressive distributed lag approach to cointegration analysis. Controlling for the possible effects of crude oil price and trade openness on economic advancement in Nigeria, this study found the relationship between micro-credit lending to Small Scale Enterprises and economic advancement is negative and significant in the long‐run and positive but insignificant in the short‐run, thus, suggesting the weakness of financial intermediary sector in resource mobilization and allocation in Nigeria. The result, in general, illustrates the vulnerability of the financial sector in stimulating economic advancement by providing micro-credit for small businesses and the unbanked. Hence, this study suggests a well‐articulated policy framework that will facilitate access to financial services.
Bacterial Oxygen Sensing by Globin‐Coupled Sensor Proteins
Authors: Hoque Nushrat J. , Weinert Emily E. 
Published: December 2024

Abstract
Organisms adapt to fluctuating oxygen levels using a variety of strategies, including coupling sensory domains to regulatory functions that modulate physiology and phenotypes. Globin‐coupled sensor proteins are multidomain proteins composed of a heme‐containing globin domain associated with a range of output domains, ranging from methyl‐accepting chemotaxis proteins, kinases, and diguanylate cyclases. These proteins have been found in the genomes of many bacteria, indicating their involvement in regulating diverse cellular pathways and behaviors in response to gaseous ligands. Detailed characterizations of globin‐coupled sensors have utilized a wide array of biochemical and spectroscopic methods to understand ligand binding and signal transduction in the heme domain. The diversity of the globin‐coupled sensory family studied to date highlights unique ligand‐binding characteristics in the heme pocket. While the characterization of the globin‐coupled sensor family has elucidated the mechanisms by which oxygen binds the heme moiety and influences the activity of these sensor protein output domains, the downstream proteins and pathways governed by globin‐coupled sensor signaling are not well understood. Given the breadth of the globin‐coupled sensors studied to date, additional research is needed further to elucidate the role of globin‐coupled sensor proteins in managing oxygen‐dependent microbial physiology both in vitro and in vivo.
Calibration and volunteer testing of a prototype contactless respiratory motion detection system based on laser tracking
Authors: Islami Isnaini Nur , Muhamadi Amar Ma'ruf Irfan , Wibowo Wahyu Edy , Putranto Aloysius Mario Yudi , Sudarmaji Arief , Djuita Fielda , Pawiro Supriyanto Ardjo 
Published: December 2024

AbstractPurposeThe goal of this study was to assess the feasibility of a cost‐effective prototype of a laser‐based respiratory motion detection system utilizing a Leuze LDS for breath monitoring through calibration and volunteer tests.MethodsThis study was performed using the Anzai AZ‐773 V and computerized imaging reference systems (CIRS) motion phantoms for calibration tests. The calibration of the laser‐based respiratory motion detection system involved spatial accuracy testing, amplitude calibration, and temporal accuracy. Volunteer testing was conducted on eight volunteers at the inferior end of the sternum and the abdomen area. The accuracy of the data recorded by the laser‐based respiratory motion detection system was validated against established clinical reference tracking systems namely real‐time position management (RPM) and Anzai AZ‐733 V system.ResultsCalibration with an Anzai AZ‐773 V and CIRS phantoms demonstrated an average error of 1.17% ± 0.64% and an average amplitude calibration correlation coefficient of 0.975 ± 0.004. Volunteer tests, compared to the Anzai AZ‐733 V clinical system and RPM system, revealed average correlation coefficients for deep inspiration breath‐hold are 0.931 ± 0.02 and 0.936 ± 0.03, respectively, and for free breathing are 0.85 ± 0.07 and 0.77 ± 0.1, respectively.ConclusionsOverall, the data suggest that the in‐house laser‐based respiratory motion detection system performed well, with an error percentage below 10%. A reasonably good correlation coefficient was obtained, indicating that the readings obtained from the laser system are consistent with those set on the phantom and clinical respiratory motion detection systems. Although promising through the calibration process and volunteer tests, further studies are required to generate trigger data linked directly to computerized tomography and linear accelerator facilities, thereby advancing the clinical viability of this innovative laser‐based respiratory motion detection system.
Partial and full arc with DynamicARC technique in pencil beam scanning proton therapy for bilateral head and neck cancer: A feasibility and dosimetric study
Authors: Rana Suresh , Padannayil Noufal Manthala , Pokharel Shyam , Saeed Hina , Kasper Michael 
Published: December 2024

AbstractPurposeA novel proton beam delivery method known as DynamicARC spot scanning has been introduced. The current study aims to determine whether the partial proton arc technique, in conjunction with DynamicARC pencil beam scanning (PBS), can meet clinical acceptance criteria for bilateral head and neck cancer (HNC) and provide an alternative to full proton arc and traditional intensity‐modulated proton therapy (IMPT).MethodThe study retrospectively included anonymized CT datasets from ten patients with bilateral HNC, all of whom had previously received photon treatment. The clinical target volumes (CTV) were categorized into three levels: CTV_7000, CTV_5950, and CTV_5600. IMPT plans included three beams, whereas DynamicARC plans included dual‐partial‐arcs (DPA), single‐partial‐arc (SPA), and single‐full‐arc (SFA). All plans underwent robust optimization considering setup (± 3 mm) and range (± 3%) uncertainties applied to the CTVs. DynamicARC plans were evaluated against the NRG‐HN009 criteria and IMPT plans using various metrics.ResultsAll four techniques—IMPT, DPA, SPA, and SFA—demonstrated substantial compliance with NRG‐HN009 dosimetric criteria. DynamicARC produced superior dose conformity, lower hotspot, and improved homogeneity for high‐risk CTV compared to IMPT, with comparable performance for intermediate‐ and low‐risk CTVs. DynamicARC reduced the Dmean to the parotid glands by average differences of 14.5%–22.1% and to the oral cavity by an average difference of 15.75% compared to IMPT. DPA and SPA techniques achieved reductions in total integral dose of 3.7%–5.7% relative to IMPT. Overall, DPA yielded dosimetric results comparable to those of SFA while offering more conformal dose distributions and slightly better organ at risk sparing than SPA.ConclusionOn the ProteusOne with a partial gantry system, DPA and SPA, in conjunction with DynamicARC PBS protons, provided clear dosimetric advantages over three‐field IMPT. Future clinical implementation and further research into optimizing DynamicARC protocols are warranted to fully realize the benefits of these techniques in clinical settings.
Unveiling the Potential of Natural Resources‐Derived Therapeutics for Improved Malaria Management: Computational to Experimental Studies
Authors: Okoh Michael P. , Egua Maxwell O. , Alli Lukman A. , Dalu Damayanthi , Gundamaraju Rohit , Singla Rajeev K. , Shen Bairong 
Published: December 2024

AbstractMalaria kills millions of people annually, and it is one of the major causes of preventable mortality in the world. Of the different plasmodium species that induce malaria, Plasmodium falciparum and Plasmodium vivax account for the most severe form of malarial disease in humans. This review focuses on understanding preventive measures, mutation‐based disease evolution, malaria‐related biomarkers, and potential plant bioactive components for the treatment and management of malaria. The burden of malaria drug resistance has made it necessary for scientists to focus on alternative therapeutics, with particular interests in those involving plant‐based bioactive components that could mediate biochemical pathways, consisting of metabolic interactions essential for parasitic inhibition. To avoid artefacts or false positives, these bioactive components from plant sources are further filtered using the “pan‐assay‐interfering compounds” (PAINS) tool. This review discussed the history of malaria treatment, current treatment options, malaria preventive measures, and challenges associated with current treatment strategies. Additionally, this work discusses the barriers while developing drugs from phytochemicals and the steps needed to accelerate the development of new antimalarial from the lead compounds.
Light‐Directed Microalgae Micromotor with Supramolecular Backpacks for Photodynamic Therapy
Authors: Wang Zeyu , Yang Zhiqing , Li Sen , Kwong Cheryl H.T. , Zhang Daiyan , Wei Jianwen , Gao Cheng , Zhang Qing‐wen , Wang Ruibing 
Published: December 2024

AbstractIn recent years, the development of micromotors for biomedical applications has surged. However, challenges such as immunogenicity and the difficulty in controlling motion direction have hindered their clinical translation. In this study, Chlamydomonas reinhardtii, a natural unicellular green microalgae known for its biocompatibility and phototaxis properties in hydrogen peroxide environments is applied, as a micromotor for efficient drug delivery and photodynamic therapy. 5‐Aminolevulinic acid‐loaded liposomes are anchored onto the surface of algae through host–guest complexation between β‐cyclodextrin‐modified algae and adamantane‐modified liposomes. This created a micromotor capable of carrying a drug‐loaded backpack for light‐driven tumor targeting and drug delivery. Additionally, light irradiation activates the photosynthesis of chloroplasts in microalgae leading to oxygen production and alleviation of the tumor's hypoxic microenvironment. In tumor‐bearing mice, light irradiation on tumor tissue directs the micromotor to accumulate in the tumor region, significantly increasing the local drug concentration from 0.007 to 0.069 mg mL−1 compared to free liposomes. Furthermore, oxygen generated from photosynthesis enhances the efficacy of photodynamic therapy, resulting in complete tumor regression in Balb/c mice after 14 days. This system achieves a three‐in‐one effect, combining targeted drug delivery, oxygen generation, and photodynamic treatment. These findings hold promise for the advancement of micromotor‐based biomedical applications.
Built‐In Electric Field Induced Uniform Li Deposition via Construction of CoP/Co2P Heterojunction in 3D Carbon Nanofiber Networks
Authors: Hao Zhimin , Liu Dapeng , Zuo Xintao , Yu Haohan , You Tingting , Zhang Yu 
Published: December 2024

AbstractUncontrollable dendrite growth significantly hinders the application of Li metal anodes. To improve the uniformity of Li deposition, it is essential to develop an inorganic‐rich solid‐electrolyte interphase (SEI) and lithiophilic host surface. However, there exists a big challenge in simultaneously optimizing SEI and anode surface. Herein, the cobalt phosphide/dicobalt phosphide (CoP/Co2P) pp‐heterojunction modified carbon nanofiber networks (CNF‐CoPx) are successfully prepared as 3D Li host, which can form built‐in electric field (BIEF) to accelerate the conversion reaction kinetics of CoP into Li3P, and spontaneously derive into a new BIEF induced by the Co/Co2P Schottky heterojunction facilitates the electron transfer during Li deposition process. Consequently, the CNF‐CoPx@Li symmetric cell exhibits impressive long‐term cycling stability, maintaining low polarization for up to 600 h at a current density of 3 mA cm−2. Additionally, the CNF‐CoPx@Li||LiFePO4 full cell delivers a high‐capacity retention of 89.5% over 500 cycles at 1 C.
Homeothermic P‐Bit Computing Hardware with Stochastic Operations Beyond Limit of Non‐Stochastic Materials
Authors: Maeng Ho‐Young , Han Joon‐Kyu , Han Janguk , Lee Soo Hyung , Cheong Sunwoo , Hwang Cheol Seong , Choi Yang‐Kyu 
Published: December 2024

AbstractProbabilistic computing (p‐computing) is a customized approach for solving complex combinatorial optimization problems. However, issues of compatibility with well‐established complementary metal‐oxide‐semiconductor (CMOS) technology, robustness to environmental temperature variations and stochasticity need to be addressed. This study resolves these difficulties using a metal‐oxide‐semiconductor field‐effect transistor (MOSFET) with a floating body as a probabilistic‐bit (p‐bit) device. Unlike previously reported two‐terminal p‐bit structures, such as magnetic tunnel junction (MTJ) and memristor‐based devices, a MOSFET is commercialized for conventional von Neumann computing. Although MOSFET operation is sensitive to the ambient temperature, a homeothermic characteristic from 20 °C up to 110 °C is achieved with gate voltage (VG) control, taking advantage of the three‐terminal design. The conventional MOSFET operation is stable, reproducible, and, thus, non‐stochastic. However, the floating body effect in this specific MOSFET enhances stochasticity, enabling an irregular single transistor latch (STL). Invertible logic operations and a max‐cut solver are demonstrated with the proposed p‐bits, maintaining desirable performance even at 110 °C through VG control. Due to its compatibility with CMOS technology, large‐scale cointegration of a p‐bit array and supportive CMOS circuits is feasible.
Topographic Scanning Electronic Microscopy Reveals the 3D Surface Structure of Materials
Authors: Sun Wen , Xu Yichen , Zhou Ying , Zeng Zhihan , Wang Lei , Ouyang Jianyong 
Published: December 2024

AbstractScanning electron microscopy (SEM) is a very popular technology to analyze the surface morphology of various materials in both academia and industry. Its principle is the detection of secondary electron emission and electron scattering interactions between the electron beam and the sample surface. It requires the deposition of a thin metal film like Au on non‐conductive samples to prevent charge accumulation. However, due to the discontinuity of the Au film along the vertical direction of a sample, the SEM images cannot provide information along the vertical direction. Additionally, the gold films have grains of 10–12 nm in diameter, which can limit the resolution of the SEM images. Here, topographic SEM is reported by coating poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS, an intrinsically conductive polymer) onto samples instead of metal deposition. High‐quality features along both the horizontal and vertical directions can be observed on the SEM images because PEDOT:PSS can form a continuous film along both directions. Furthermore, due to the featureless morphology of the PEDOT:PSS films, the resolution of SEM images is significantly higher than that with gold deposition. The application of topographical SEM in the characterization of various materials, including patterned semiconductors, nanostructured materials, energy materials, biomaterials, etc is demonstrated.
Another Way to Realize LiMn2O4 as a Solid Electrolyte
Authors: Du Jingzhen , Sun Zewen , Peng Bohao , Xu Xuming , Fu Lijun , Chen Yuhui , Liu Lili , Liu Xu , Wu Yuping 
Published: December 2024

AbstractThe development and application of solid‐state electrolytes (SSEs) play a crucial role in advancing lithium metal batteries (LMBs). Consequently, the search for high‐performance, economic, and easily fabricated SSEs has become a prevailing trend. In this work, we explore an alternative approach to design the traditional commercial lithium‐ion batteries cathode material, spinel‐type LiMn2O4 (LMO) as a SSE. By blending LMO with poly(vinylidene difluoride) and combining with two layers of polyethylene (PE) film on the top and bottom, we effectively reduce its high electronic conductivity, thereby creating the PE/LMO/PE SSE. The PE/LMO/PE SSE demonstrates high ionic conductivity (3.15 × 10−4 S cm−1 at 35°C), low electronic conductivity (7.31 × 10−11 S cm−1), and good interfacial contact and stability with both the lithium metal anode, LiFePO4 and nickel‐rich Li[Ni0.8Co0.1Mn0.1]O2 cathodes. This study offers a new direction for the application of the electrochemically active cathode material LMO, while providing a simple and feasible solution to reduce the electronic conductivity of SSEs. Additionally, it opens up new perspectives for selecting high‐performance SSEs for use in LMBs, paving an alternative economic path toward the commercialization of solid‐state lithium metal batteries.
Effective Hydrogel Vascular Patch Dual‐Loaded with Cycloastragenol Nanostructured Lipid Carriers and Doxycycline for Repairing Extravascular Injury in Abdominal Aortic Aneurysm
Authors: Chen Du , Song Tiantian , Liu Yi , Wang Ying , Qin Boyang , Zhang Qingyi , Hu Weipeng , Zhou Xiqiao , Qi Rong 
Published: December 2024

AbstractEndovascular aneurysm repair (EVAR) plays a crucial role in the treatment of abdominal aortic aneurysm (AAA) in the clinic, but the aneurysm remains in the patient's body after surgery, continuing to pose a risk of progression. Cycloastragenol (CAG) is proven to be an effective anti‐AAA drug, and its vascular protective effects can be further improved when the hydrophobic CAG is encapsulated into nano‐sized formulations to enhance its bioavailability. In this context, this study developed an extravascular patch hydrogel loaded with CAG nanostructured lipid carriers and a hydrophilic drug of doxycycline hydrochloride (DOX). The extravascular patch delivered onto the mouse abdominal aortas can promote local permeation of hydrophilic/hydrophobic drugs at the vessel sites and provide effective vascular protection against AAA injury induced by elastase. This study introduces a novel and promising approach for AAA treatment, which can serve as a supplementary strategy after EVAR surgery.
A Microenvironment‐Responsive Graphdiyne‐Iron Nanozyme Hydrogel with Antibacterial and Anti‐Inflammatory Effect for Periodontitis Treatment
Authors: Wu Xiaojie , Wang Lu , Lu Yaning , Li Meng‐Hao , Liu Shuwei , Yang Yimeng , Song Yulian , Chen Sunzhuo , Kang Jing , Dong Alideertu , Yang Ying‐Wei 
Published: December 2024

AbstractPeriodontitis is a chronic inflammatory disease caused by dental plaque, which leads to tooth loosening and shifting or even tooth loss. Current treatments, including mechanical debridement and antibiotics, often fail to eradicate recalcitrant biofilms and mitigate excessive inflammation. Moreover, these interventions can disrupt the oral microbiome, potentially compromising long‐term treatment outcomes. To address these limitations, an injectable nanoenzyme hydrogel composed of a dopamine (DA)‐modified hyaluronic acid (HA) scaffold and a graphdiyne‐iron (GDY‐Fe) complex, named GDY‐Fe@HA‐DA, exhibits excellent tissue adhesion, self‐healing, antibacterial properties, and biocompatibility. Under near‐infrared laser irradiation, GDY‐Fe@HA‐DA effectively eradicates a variety of pathogens, including Escherichia coli, Staphylococcus aureus, and Porphyromonas gingivalis, through a synergistic combination of chemodynamical and photothermal therapies. The hydrogel's efficacy is further validated in both bacterial‐infected skin wounds and rat periodontitis models. It effectively alleviates the inflammatory environment and promotes wound healing and periodontal tissue recovery. This findings highlight the potential of GDY‐Fe@HA‐DA as a promising therapeutic material for periodontitis and other tissue injuries.