bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of Resistant Hypertension in Real Clinical Settings
Authors: Maltseva A. S. , Tsygankova A. E. , Gabitova M. A. , Rodionov A. V. , Fomin V. V. 
Published: May 2021

Background. Current guidelines describe in detail the approaches to the management of patients with resistant hypertension, however, in real clinical settings the number of non-rational and ineffective combinations of antihypertensive drugs used remains high.Aim. To analyze the distribution of different combinations of antihypertensive drugs for the treatment of resistant hypertension and to estimate the proportion of non-rational combinations.Methods. The retrospective analysis includes 117 outpatients with resistant hypertension. Resistant hypertension was defined as blood pressure that remains above goal despite concurrent use of three antihypertensive agents of different classes. Exclusion criteria was secondary hypertension. We defined rational combination as the standard combination (renin-angiotensin system [RAS] blocker + calcium-channel blocker [CCB] + diuretic) plus one of the group of reserve drugs (mineralocorticoid receptors antagonist [MRA], beta-blocker, alpha-blocker, agonist of imidazoline receptors [AIR]). Non-rational were considered combinations in which reserve drugs were used before the appointment of a triple combination of first-line drugs. Moreover, in a subgroup of non-rational therapy, situations were identified where such a combination was justified.Results. The proportion of rational combinations was 58.9%, reasonably non-rational - 15.5%, unreasonably non-rational - 25.6%. Unreasonably non-rational combinations are distributed as follows: non-appointment of CCB - 12%, non-appointment of RAS-blockers - 8%, non-appointment of diuretics - 6%, use of RAS-blockers for hyperkalemia - 6%, administration of MRA without non-potassium-sparing diuretics - 5%, double blockade of RAS - 3%, other combinations - 7%. In addition to first-line drugs, beta-blockers (93.2%), loop diuretics (22.2%), AIR (21.4) were the most prescribable, while the proportion of MRA is only 15.4% of the entire sample.Limitation: some patient's characteristics could be missed in case histories and some of the combinations could be falsely recognized as malpractice since the analysis was conducted retrospectively.Conclusion. The proportion of the non-rational combinations for the treatment of resistant hypertension is high. Among the drugs of the reserve, the frequent use of beta-blockers and moxonidine and the inadequate administration of spironolactone are noteworthy. The problem of treatment strategy choice remains relevant in real clinical practice.
Dynamics of Kidney Function in Patients with Chronic Kidney Disease and Atrial Fibrillation Who Receive Dabigatran
Authors: Novikova N. A. , Salpagarova Z. K. , Chashkina M. I. , Bykova A. A. , Alimova Z. A. , Yadykina А. S. , Mesitskaya D. F. , Babakova N. A. , Andreev D. A. 
Published: May 2021

Atrial fibrillation (AF) is the most frequent type of supraventricular arrhythmias. The anticoagulant therapy should be prescribed to prevent thromboembolic events. According to randomized clinical trials, anticoagulants do not always prove their high efficiency in the real clinical practice. It is a complicated issue for any doctor to prescribe the anticoagulant therapy for patients with AF and CKD. 30 % of patients with atrial fibrillation are known to have chronic kidney disease, while 10-15% of patients with chronic kidney disease are diagnosed with atrial fibrillation. Currently, there are scarce studies into the use of direct oral anticoagulants in patients with atrial fibrillation and chronic kidney disease (in case of Glomerular Filtration Rate (GFR) below 45 ml/min/1.73 m2).Aim. To determine the dynamics of GFR in patients with AF and CKD (in case of GFR below 45 ml/min/1.73 m2).Material and Methods. The sub-analysis was carried out to examine a single-centre prospective study into the optimization of the anticoagulant therapy in the outpatient practice. Initially, 133 dabigatran taking patients were enrolled in the study, and 79 patients were included in the final analysis. Endpoints were changes in Glomerular Filtration Rate (CKD-EPI) formulae as of the inclusion date, in 6, 12, 24 and 60 months after the inclusion. Changes in the renal function shall mean a decrease or increase in GFR by ≥5 ml/min.Results. The average follow-up period for patients was 1785 ± 218 days. A GFR>45 ml/min/1.73 m2 occurred in 116 (87.2%) patients, and a GFR <45 ml/min/1.73 m2 was found in 17 (12.8%) patients. The average HAS-BLED score was 1.8, and CHA2DS2VASc score - 3.8. During the observation period, there were 3 cases of major bleeding and 133 cases of minor bleeding. Both major (р=0.025) and minor (р=0.012) bleeding were statistically significant more frequent in patients with GFR below 45 ml/min. During 5 years of follow-up, 66 (49.6%) patients had an average decrease in GFR of 3.32 ml/min/1.73 m2 per year. Patients with the initially declined GFR (below 45 ml/min) did not demonstrate a significant dynamic of the renal function during the dabigatran therapy. The mortality rate in this group during the observation period was 61.5%.Conclusion. In 49.6% of patients during 5 years of follow-up, GFR decreased by an average of 3.32 ml/min/1.73 m2 per year, which does not exceed the indicators typical for patients with cardiovascular events and CKD.
Main Factors Related with the White Coat Effect Level in Patients with Arterial Hypertension and Bronchial Asthma
Authors: Andreeva G. F. , Smirnova M. I. , Gorbunov V. M. , Kurekhyan A. S. , Koshelyaevskaya Y. N. 
Published: May 2021

Aim. To study the main relationships of the white coat effect (WCE) levels in patients with arterial hypertension (AH) with bronchial asthma (BA) who treated with AH and BA drugs in routine clinical practice.Material and Methods. We analyzed the prospective cohort study data of AH patients, some of them had BA without exacerbation. We have formed two groups of patients:1 - control group, patients with AH without BA, the second - with AH + BA. The study consisted of three visits (first visit, 6 months and 12 months visits) and data collection period (30.1±7.6 months of follow-up). The following procedures were performed at the first and 12 month visits: clinical blood pressure (BP) measurements (sitting and standing), 24-hour monitoring ambulatory (ABPM), spirometry, clinical and biochemical blood tests, BA control questionnaires (ACQ) and quality of life (QL) questionnaire (GWBQ), at the second visit clinical BP measurement was performed and, if necessary, the drug dose was corrected.Results. The study included 125 patients, 28 men, 97 women. The first group of AH patients without BA included 85 people, the second (AH + BA) - 40. In AH patients without BA with ischemic heart disease, arterial revascularization, regular alcohol intake and smoking we identified the association with the lower WCE levels. In AH+BA patients with diabetes mellitus, gastrointestinal diseases, higher education was identified WCE decrease. In AH patients without asthma we found inverse relationships WCE levels with respiratory function parameters, the nighttime BP decrease, heart rate and the difference between standing and sitting BP levels, and correlations with the EchoCG variables (the left ventricular hypertrophy (LVH) indices), with age, AH duration and body mass index (BMI). In patients with AH + BA we found inverse correlations between WCE levels and some EchoCG variables, the difference between standing and sitting BP levels, and correlations with body weight, BMI.Conclusion. Thereby, in AH patients without BA with ischemic heart disease, revascularization, regular alcohol intake, smoking we identified the association with the lower WCE levels. This patients WCE indices had inverse correlations with height, respiratory function parameters, the BP nighttime decrease, the difference between standing and sitting BP levels and direct relationships with EchoCG variables of LVH, age, AH duration and BMI. In AH + BA patients with diabetes, gastrointestinal diseases, higher education we found relationships with lesser WCE manifestation. WCE levels in this group had inverse correlations with some EchoCG indicators, the standing and sitting BP difference and direct relations with weight and BMI.
ANALISIS TINGKAT KEPUASAN MASYARAKAT DALAM PELAYANAN PUBLIK (STUDI KASUS: DI GORONTALO UTARA)
Authors: Abdussamad Zuchri , Tahir Arifin , Arsana I Kadek Satria 
Published: May 2021

Abstrak: Analisis Tingkat Kepuasan Masyarakat Dalam Pelayanan Publik Studi Kasus: Di Gorontalo Utara. Pelayanan publik yang dilaksanakan oleh pemerintah daerah perlu dilakukan penilaian secara berkala. Hal ini berfungsi sebagai proses pembenahan layanan birokrasi pemerintahan. Tujuan penelitian ini adalah sebagai proses penilaian tingkat kepatuhan layanan yang diberikan oleh Organisasi Perangkat Daerah di Kabupaten Gorontalo Utara. Metode yang digunakan adalah mix metode yakni gabungan metode kualitatif dan kuantitatif. Untuk mendapat data yang valid maka terlebih dahulu dilakukan survei. Kesimpulannya hasil analisis survei pemerintah daerah Gorontalo Utara berkategori “Baik” dengan indeks sebesar 79.13. Bila dibandingkan dengan hasil indeks nilai kepatuhan pelayanan yang dipublikasikan oleh Ombudsman Republik Indonesia Tahun 2019 Kabupaten Gorontalo Utara memperoleh nilai sebesar 71.51. Berdasarkan hasil analisis tersebut menunjukkan bahwa ada peningkatan nilai indeks kepuasan pemerintah daerah Gorontalo Utara dari Tahun 2019 ke Tahun 2020 sebesar 7.62, nilai ini cukup signifikan. Artinya, Pemerintah Daerah Kabupaten Gorontalo Utara telah melakukan perbaikan-perbaikan dalam menunjang pelayanan publik pada setiap instansi di lingkungan pemerintahan. Kata Kunci: Survei Kepuasan Masyarakat; Pelayanan Publik; Gorontalo Utara; Pemerintah Daerah; Nilai Kepatuhan. Abstract: Analysis of Public Satisfaction Level in Public Service Case Study: In North Gorontalo. Public services implemented by local governments need to be assessed periodically. This serves as a process of improving government bureaucratic services. The purpose of this research is as a process of assessing the level of compliance of services provided by the Regional Device Organization in North Gorontalo Regency. The method used is a mix of methods that are a combination of qualitative and quantitative methods. To get valid data, a survey is first conducted. In conclusion, the results of the survey analysis of the North Gorontalo regional government are categorized as "Good" with an index of 79.13. When compared with the results of the service compliance value index published by the Ombudsman of the Republic of Indonesia in 2019, North Gorontalo District obtained a value of 71.51. Based on the results of the analysis shows that there is an increase in the satisfaction index value of the North Gorontalo regional government from 2019 to 2020 of 7.62, this value is quite significant. That is, the Regional Government of North Gorontalo Regency has made improvements in supporting public services in every agency in the government environment. Keywords: Public Satisfaction Survey; Public Service; North Gorontalo; Local Government; Compliance Value.
KETERLIBATAN KELUARGA DALAM TATA KELOLA DAN ORGANISASI PERUSAHAAN PADA KONTEKS ENTREPRENEURIAL ORIENTATION
Authors: Sienatra Krismi Budi , Laudo Syellen 
Published: May 2021

Abstrak : Keterlibatan Keluarga Dalam Tata Kelola Dan Organisasi Perusahan Pada Konteks Entrepreneurial Orientation. Perusahaan keluarga sebagai kontributor terbesar dalam pertumbuhan ekonomi, seringkali memiliki performa yang inkonsisten. Penelitian ini bertujuan mengetahui bagaimana dimensi entrepreneurial orientation dapat memberi pengaruh terhadap family firm performance. Penelitian ini menggunakan tiga dimensi entrepreneurial orientation terdiri dari innovativeness, proactiveness dan risk taking. Keterlibatan keluarga dalam pengelolaan perusahaan keluarga digunakan sebagai moderasi apakah memiliki dampak pada family firm performance. Sampel dari penelitian ialah komunitas perusahaan keluarga yang dibentuk dari universitas di Surabaya. Penelitian menggunakan alat analisis PLS. Hasil penelitian memperlihatkan bahwa proactiveness berpengaruh signifikan terhadap family firm performance sedangkan innovativeness dan risk taking tidak berpengaruh. Hasil moderasi menunjukkan keterlibatan keluarga tidak memoderasi dimensi entrepreneurial orientation terhadap family firm performance. Temuan ini memberikan gambaran bagi perusahaan keluarga yang masih skala menengah dan kecil serta belum terbuka dengan melibatkan anggota keluarga dalam tata kelola organisasi belum memiliki dampak pada kinerja perusahaan. Keterlibatan anggota keluarga hanya bersifat administratif bagi pemillik perusahaan. Abstract: Family Involvement In Governance And Company Organizations In The Context Of Entrepreneurial Orientation. Family companies, as the biggest contributors to economic growth, often have an inconsistent performance. This study aims to determine how the dimensions of entrepreneurial orientation can have an influence on family firm performance. This study uses three dimensions of entrepreneurial orientation consisting of innovativeness, proactiveness and risk taking. Family involvement in the management of family companies is used as moderation whether it has an impact on family firm performance. The sample of this research is a family company community formed from a university in Surabaya. The research used PLS analysis tool. The results showed that proactiveness had a significant effect on family firm performance, while innovativeness and risk taking had no effect. The result of moderation shows that family involvement does not moderate the dimensions of entrepreneurial orientation towards family firm performance. These findings provide an overview for family companies that are still medium and small in scale and have not been open to involving family members in organizational governance yet have an impact on company performance. The involvement of family members is only administrative in nature for company owners
Reliabilitas test-retest dyer tennis test revision
Authors: Alim Abdul , Nurfadhila Risti 
Published: May 2021

Banyak faktor yang mempengaruhi pencapaian prestasi olahraga, salah satu faktor yang mempengaruhi pencapaian prestasi pada cabang olahraga tenis lapangan adalah keterampilan dalam memukul bola. Instrumen tes yang valid dan reliabel diperlukan untuk mengetahui tingkat keterampilan pukulan untuk menentukan dan memantau hasil latihan. Tujuan penelitian ini adalah untuk mengetahui reliabilitas tes akurasi pukulan tenis lapangan menggunakan Dyer Tennis Test Revision. Pemilihan Dyer Tennis Test Revision sebagai intrumen tes pengukuran keterampilan akurasi pukulan tenis disesuaikan dengan subjek penelitian yaitu petenis pemula mahasiswa. Sembilan puluh tujuh mahasiswa pemula (51 laki-laki dan 46 perempuan) yang mengambil mata kuliah tenis lapangan menjadi subjek dalam penelitian ini. Test retest digunakan dalam penelitian ini. Hasil analisis product moment menunjukkan bahwa nilai r adalah 0,975. Hasil terebut bermakna bahwa Dyer Tennis Test Revision dapat diandalkan untuk mengukur unjuk kerja keterampilan tenis berbasis keakuratan. Dyer Tennis Test Revision juga merupakan alat ukur yang mudah dan murah yang dapat digunakan guru/dosen/pelatih untuk memantau kemajuan pemain.Test-retest reliability for dyer tennis test revisionAbstractMany factors affect sports performance, one of the factors that affect performance in tennis is the skill in hitting the ball. A valid and reliable test instrument is needed to determine the skill level of the stroke to determine and monitor the results of the training. The purpose of this study was to determine the reliability of the hitting tennis accuracy test using the Dyer Tennis Test Revision. The choice of Dyer Tennis Test Revision as a test instrument for measuring the accuracy of tennis strokes was adjusted to the research subject, namely student novice tennis players. Ninety-seven (beginner students (51 male and 46 female) who took tennis court courses were the subjects in this study. The retest test was used in this study. The results of the product moment analysis show that the value of r is 0.975. These results mean that the Dyer Tennis Test Revision can be relied upon to measure the performance of tennis skills based on accuracy. Dyer Tennis Test Revision is also an easy and inexpensive measuring tool that teachers / lecturers / coaches can use to monitor player progress.
Pengaruh ICT Self Efficacy terhadap Technopreneurship Intention dimediasi Motivasi Siswa
Authors: Fathonah Wulan Nur , Machmud Amir , Suwatno Suwatno 
Published: May 2021

Penelitian ini memiliki tujuan untuk mengetahui dan menganalisis pengaruh ICT self efficacy terhadap technopreneurship intention dimediasi oleh motivasi siswa. Tingkat technopreneurship intention diukur melalui indikator norma subjektif, persepsi kontrol perilaku dan sikap terhadap perilaku. Tingkat ICT self efficacy diukur melalui indikator computer self efficacy dan internet self efficacy. Tingkat motivasi siswa diukur melalui indikator keinginan untuk berbuat sesuatu, dorongan atau impuls dan kekuatan motifnya. Penelitian ini menggunakan metode survei eksplanatori dengan teknik pengumpulan data melalui kuesioner yang dibagikan kepada siswa jurusan Teknik Komputer Jaringan di Sekolah Menengah Kejuruan Negeri (SMKN) 5 Bandung sebanyak 167 siswa dengan sampel sebanyak 120 siswa. Teknik analisis data menggunakan statistik deskriptif, statistik inferensial dan analisis regresi. Hasil penelitian ini menunjukkan 1) tingkat technopreneurship intention, ICT self efficacy dan motivasi siswa berada pada kategori tinggi. 2) ICT self efficacy berpengaruh positif dan signifikan terhadap technopreneurship intention dan 3) motivasi siswa memediasi pengaruh ICT self efficacy terhadap technopreneurship intention. Temuan penelitian ini menjelaskan bahwa untuk meningkatkan technopreneurship intention siswa harus diselaraskan dengan meningkatkan ICT self efficacy dan motivasi siswa.
Evaluación de características fisicoquímicas, compuestos fenólicos, contenido de minerales y color de mieles comerciales del Cauca (Colombia)
Authors: Ortega-Bonilla Rubén Andrés , Morales-Hormiga Carlos Hernán , Chito-Trujillo Diana María 
Published: May 2021

La producción de miel en Colombia es una actividad secundaria destinada principalmente al abastecimiento regional. A nivel nacional, el departamento del Cauca ocupa el séptimo lugar en producción de miel. La miel como alimento debe satisfacer las preferencias del consumidor y los criterios de calidad exigidos por la legislación para garantizar sus propiedades nutricionales y funcionales. Estas características se asocian a factores tales como origen botánico y geográfico, prácticas apícolas, entre otros. El origen geográfico de diferentes mieles se puede definir a partir de sus parámetros fisicoquímicos. En este trabajo se analizaron las características fisicoquímicas (acidez libre, pH, °Brix, cenizas, conductividad eléctrica, materia insoluble y humedad), el contenido de compuestos fenólicos totales (CFT), minerales, y el color (escala PFund y CIELab) de veinticuatro muestras de mieles comerciales adquiridas en seis municipios del departamento del Cauca (Colombia): Caldono, La Vega, Paispamba, Silvia, Timbío y Totoró. No todas las muestras cumplieron los requerimientos de la Norma Técnica Colombiana NTC-1273 para mieles florales, excepto las de Silvia, y alrededor del 20 % de las muestras mostró características de mieles de mielada. El color predominante en las mieles analizadas fue ámbar claro y ámbar, y se encontró una fuerte correlación entre los parámetros color expresado en mm PFund y CFT (r = 0,9229, p < 0,05). El análisis de componentes principales (ACP) permitió distinguir parcialmente las mieles de Paispamba, Silvia y Totoró a partir de sus parámetros fisicoquímicos y contenido mineral. Se sugiere el análisis de más muestras de miel para lograr una diferenciación por origen geográfico.
Mobile App (WHEELS) to Promote a Healthy Lifestyle in Wheelchair Users With Spinal Cord Injury or Lower Limb Amputation: Usability and Feasibility Study
Authors: Hoevenaars Dirk , Holla Jasmijn F M , te Loo Leonie , Koedijker Johan M , Dankers Sarah , Houdijk Han , Visser Bart , Janssen Thomas W J , de Groot Sonja , Deutekom Marije ,   WHEELS Study Group
Published: May 2021

Background
Maintaining a healthy lifestyle is important for wheelchair users’ well-being, as it can have a major impact on their daily functioning. Mobile health (mHealth) apps can support a healthy lifestyle; however, these apps are not necessarily suitable for wheelchair users with spinal cord injury or lower limb amputation. Therefore, a new mHealth app (WHEELS) was developed to promote a healthy lifestyle for this population.

Objective
The objectives of this study were to develop the WHEELS mHealth app, and explore its usability, feasibility, and effectiveness.

Methods
The WHEELS app was developed using the intervention mapping framework. Intervention goals were determined based on a needs assessment, after which behavior change strategies were selected to achieve these goals. These were applied in an app that was pretested on ease of use and satisfaction, followed by minor adjustments. Subsequently, a 12-week pre-post pilot study was performed to explore usability, feasibility, and effectiveness of the app. Participants received either a remote-guided or stand-alone intervention. Responses to semistructured interviews were analyzed using content analysis, and questionnaires (System Usability Score [SUS], and Usefulness, Satisfaction, and Ease) were administered to investigate usability and feasibility. Effectiveness was determined by measuring outcomes on physical activity, nutrition, sleep quality (Pittsburgh Sleep Quality Index), body composition, and other secondary outcomes pre and post intervention, and by calculating effect sizes (Hedges g).

Results
Sixteen behavior change strategies were built into an app to change the physical activity, dietary, sleep, and relaxation behaviors of wheelchair users. Of the 21 participants included in the pilot study, 14 participants completed the study. The interviews and questionnaires showed a varied user experience. Participants scored a mean of 58.6 (SD 25.2) on the SUS questionnaire, 5.4 (SD 3.1) on ease of use, 5.2 (SD 3.1) on satisfaction, and 5.9 (3.7) on ease of learning. Positive developments in body composition were found on waist circumference (P=.02, g=0.76), fat mass percentage (P=.004, g=0.97), and fat-free mass percentage (P=.004, g=0.97). Positive trends were found in body mass (P=.09, g=0.49), BMI (P=.07, g=0.53), daily grams of fat consumed (P=.07, g=0.56), and sleep quality score (P=.06, g=0.57).

Conclusions
The WHEELS mHealth app was successfully developed. The interview outcomes and usability scores are reasonable. Although there is room for improvement, the current app showed promising results and seems feasible to deploy on a larger scale.