bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of sarcopenia on rehabilitation outcomes after total knee replacement in older adults with knee osteoarthritis
Authors: Liao Chun-De , Chen Hung-Chou , Huang Shih-Wei , Liou Tsan-Hon 
Published: March 2021

Introduction: Knee osteoarthritis (KOA) is associated with an increased risk of sarcopenia, and aging-related muscle deterioration continues after total knee replacement (TKR). Low skeletal muscle mass index may influence postoperative rehabilitation outcomes. Through this study, we aimed to investigate the impact of preoperative sarcopenia on clinical outcomes after postoperative rehabilitation in older Asian adults. Methods: A total of 190 older adults (39 men, 151 women) were enrolled from two previous trials and were classified as having no sarcopenia, class I sarcopenia, or class II sarcopenia according to definitions provided by the Asian Working Group for Sarcopenia (AWGS) and the European Working Group on Sarcopenia in Older People (EWGSOP). All patients were retrospectively analyzed before (T0) and after (T1) TKR rehabilitation and 10 months after surgery (T2). The outcome measures included the timed up-and-go test (TUGT), gait speed (GS), timed chair rise (TCR), and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and physical difficulty (WOMAC-PF). With patient characteristics and T0 scores as covariates, an analysis of variance was performed to identify intergroup differences in changes of all outcome measures at T1 and T2. Results: According to the definitions of both the AWGS and EWGSOP, patients with class I and class II sarcopenia exhibited minor changes in TUGT, GS, TCR, and WOMAC-PF at T1 and T2 (all p < 0.05), compared with those without sarcopenia. For patients classified as having sarcopenia based on AWGS and EWGSOP definitions, no significant intergroup differences in WOMAC pain score was observed at T1 or T2 (all p > 0.05). Conclusions: Sarcopenia independently had negative impacts on the treatment effects of rehabilitation on physical mobility but not on pain outcome after TKR in older adults with KOA.
Evaluations for New Healthcare Environment Commissioning and Operational Decision Making Using Simulation and Human Factors: A Case Study of an Interventional Trauma Operating Room
Authors: Dubé Mirette , Laberge Jason , Sigalet Elaine , Shultz Jonas , Vis Christine , Ball Chad G. , Kirkpatrick Andrew , Biesbroek Susan 
Published: March 2021

Purpose: The aim of this article is to provide a case study example of the preopening phase of an interventional trauma operating room (ITOR) using systems-focused simulation and human factor evaluations for healthcare environment commissioning. Background: Systems-focused simulation, underpinned by human factors science, is increasingly being used as a quality improvement tool to test and evaluate healthcare spaces with the stakeholders that use them. Purposeful real-to-life simulated events are rehearsed to allow healthcare teams opportunity to identify what is working well and what needs improvement within the work system such as tasks, environments, and processes that support the delivery of healthcare services. This project highlights salient evaluation objectives and methods used within the clinical commissioning phase of one of the first ITORs in Canada. Methods: A multistaged evaluation project to support clinical commissioning was facilitated engaging 24 stakeholder groups. Key evaluation objectives highlighted include the evaluation of two transport routes, switching of operating room (OR) tabletops, the use of the C-arm, and timely access to lead in the OR. Multiple evaluation methods were used including observation, debriefing, time-based metrics, distance wheel metrics, equipment adjustment counts, and other transport route considerations. Results: The evaluation resulted in several types of data that allowed for informed decision making for the most effective, efficient, and safest transport route for an exsanguinating trauma patient and healthcare team; improved efficiencies in use of the C-arm, significantly reduced the time to access lead; and uncovered a new process for switching OR tabletop due to safety threats identified.
Psychological impact of COVID-19 on health workers in Ghana: A multicentre, cross-sectional study
Authors: Ofori Anthony Amanfo , Osarfo Joseph , Agbeno Evans Kofi , Manu Dominic Owusu , Amoah Elsie 
Published: March 2021

Introduction: The COVID-19 pandemic has exacted an appreciable burden on health systems globally including adverse psychological impacts on health workers. This study sought to assess COVID-19-related fear, depression, anxiety and stress among hospital staff, potential factors that may help reduce its psychological effects and their personal coping strategies. The study will help to highlight the psychological impact of COVID-19 on Ghanaian health workers and indirectly serve as a needs assessment survey for input to support affected staff and the broader health system. Methods: A cross-sectional survey was conducted among health workers in three hospitals in the Ashanti Region of Ghana from 11 July 2020 to 12 August 2020. Demographic data and scores from the validated DASS-21 and Fear of COVID-19 scales and two other scales developed de novo were entered from 272 self-administered questionnaires and analyzed for means, frequencies and proportions. Fisher’s exact test analysis was done to ascertain associations between selected independent variables and depression, anxiety, stress and fear. Parametric and non-parametric tests were used to compare the mean and median scores of the outcome variables across the three study hospitals. Results and conclusion: Over 40% of respondents had fear while 21.1%, 27.8% and 8.2% had depression, anxiety and stress, respectively. Positive attitudes from colleagues and the government’s tax-free salary relief were some factors said to reduce the psychological effects while over half of participants indicated praying more often as a coping strategy. There is a need for the health system to recognize the presence of these adverse psychological effects in health workers and take pragmatic steps to address them.
Knowledge of obstetric danger signs and associated factors among pregnant women in Wolaita Sodo town, South Ethiopia: A community-based cross-sectional study
Authors: Bolanko Alemu , Namo Hussen , Minsamo Kirubel , Addisu Nigatu , Gebre Mohammed 
Published: March 2021

Introduction: Obstetric complications continue to be the major causes of maternal mortality in low- and middle-income countries. Knowledge of women toward obstetric danger signs is an important part of improving maternal and fetal outcomes. However, the reported level of knowledge on obstetric danger signs is low and inconsistent. Methods: Community-based cross-sectional study design was used. Data were collected from randomly selected 740 pregnant women. A pregnant woman said to have good knowledge of obstetric danger signs if she spontaneously mentioned at least two of the danger signs during each of the three periods (pregnancy, labor/childbirth, and postpartum) and otherwise said to have poor knowledge of obstetric danger signs. Adjusted odds ratio at 95% confidence interval and a value of p < 0.05 were used to identify the predictors. Results: A total of 740 pregnant women participated in the study with the response rate of 97.5%. One hundred twenty-four (16.8%) of the respondents were knowledgeable about obstetric danger signs. According to our study, age range of 20–24 years (adjusted odds ratio = 6, confidence interval: 2.67–17.44) and 25–29 years old (adjusted odds ratio = 2.4, confidence interval: 1.14–5.10); being housewife (adjusted odds ratio = 0.5, confidence interval: 0.28–0.87); monthly income of ⩽1000ETB (adjusted odds ratio = 0.24, confidence interval: 0.12–0.46) and 1001-2500ETB (adjusted odds ratio = 0.24, confidence interval: 0.12–0.47); and primigravida (adjusted odds ratio = 0.09, confidence interval: 0.04–0.18) and primipara (adjusted odds ratio = 0.15, confidence interval: 0.07–0.30) were factors significantly associated with knowledge of obstetric danger signs. Conclusion: Knowledge of obstetric danger signs among pregnant women was low. Maternal age, average monthly income, maternal occupation, parity, and gravidity were factors significantly associated with the knowledge of obstetric danger signs.
Bibliometric analysis of the top 100 cited articles in head and neck radiology
Authors: Oo Aye MM , Chu Timothy SM 
Published: March 2021

Background Bibliometric analysis is commonly used to identify influential research within a given topic. Purpose To identify the 100 top-cited articles in head and neck radiology, analyse the history and trends in head and neck imaging research, and understand what constitutes a highly cited work. Material and Methods A literature search was performed on the Thomson Reuters Web of Science using pre-defined search terms. The results were ranked according to citation count and screened to create a single database. The information included in the database were: Web of Science citations, year published, first author, primary institution, country of origin, journal, journal impact factor, title, study design, study focus and modality. Results 24,664 eligible papers were returned. Citations for the 100 top-cited articles ranged from 115 to 1185, and citations per year ranged from 3.5 to 197.5. More than half of the articles were published in the 2000s ( n = 67). Radiology has the greatest number of publications ( n = 22), followed by Journal of Nuclear Medicine ( n = 14). Positron Emission Tomography ( n = 56) was the most commonly studied modality, followed by Magnetic Resonance ( n = 40) and Computed Tomography ( n = 31). The most common topics of publication were diagnosis ( n = 63), followed by prognosis ( n = 16). Conclusion This study provides insights into the most influential research in head and neck radiology in the current time. It also serves as a guide to the characteristics of a highly cited work in this field.
Ability of a Risk Prediction Tool to Stratify Quality and Cost for Older Patients With Operative Distal Radius Fractures
Authors: Adenikinju Abidemi , Ranson Rachel , Rettig Samantha A. , Egol Kenneth A. , Konda Sanjit R. 
Published: March 2021

Introduction: Distal radius fractures are the second most common fracture in the elderly population. The incidence of these fractures has increased over time, and is projected to continue to do so. The aim of this study is to utilize a validated trauma risk prediction tool to stratify middle-aged and geriatric patients with operative distal radius fractures as well as compare hospital quality metrics and inpatient hospitalization costs among the risk groups. Materials and Methods: Patients were prospectively enrolled in an orthopedic trauma registry. The Score for Trauma Triage in Geriatric and Middle Aged (STTGMA) was calculated using patient demographics, injury severity, and functional status. Patients were then stratified into minimal-risk, moderate-risk, and high-risk cohorts based on their scores. Length of stay, need for escalation of care, complications, mortality, discharge location, 1-year patient reported outcomes, and index admission costs were evaluated. Results: Ninety-two patients met inclusion criteria. Sixty-three (68.5%) patients were managed with outpatient surgery. The mean inpatient length of stay for the high-risk cohort was 2.9x and 2.2x higher than the minimal and moderate-risk cohorts, respectively (2.0 + 2.9 days vs. 0.7 + 0.9 and 0.9 + 1.1 days, P = .019). There were no complications or mortality in any of the risk groups. No patients required intensive care and all patients were discharged home. There was no difference in readmission rates, inpatient cost, or 1-year patient reported outcomes among the risk cohorts. Discussion/Conclusions: The Score for Trauma Triage in Geriatric and Middle-Aged is able to risk-stratify patients that undergo operative intervention of distal radius fractures. Middle aged and elderly patients with isolated closed distal radius fractures can be safely managed on an outpatient basis regardless of risk. Standardized pathways can be created in the management of these injuries, thereby optimizing value-based care. Level of evidence: Prognostic Level III
Dorsal vaginal graft urethroplasty in female urethral stricture: a contemporary series
Authors: Chakraborty Joy Narayan , Vyas Nachiket 
Published: March 2021

Abstract
Background
Bladder outlet obstruction (BOO) is an uncommon entity in women. The incidence is only 2.7–8% of women referred for voiding symptoms. It is common to treat female urethral strictures by repeated urethral dilatations with subsequent self-intermittent catheterisation, which often leads to stricture recurrence. We aim to review the technique and outcomes of Dorsal vaginal graft Urethroplasty (DVGU) to manage urethral strictures in females.

Methods
This study is a retrospective chart review of 24 women with urethral stricture who underwent dorsal vaginal graft urethroplasty by a single surgeon. Patients were selected based on history, physical examination, uroflowmetry, urethral calibration, urethroscopy and voiding cystourethrography. We compared the pre- and postoperative values of variables such as the peak flow (Qmax), post-void residual (PVR) and self-reporting satisfaction score.

Results
Mean (range) age of the patients was 46.54 (38–55) years. The mean PVR was 6.35 ml/s and 148.12 ml/s, respectively. The mean Qmax before and after surgery was 6.35–25.12 ml/s, respectively (p < 0.05). The mean PVR decreased from 148.12 ml (preoperative) to 41.67 ml (postoperative) (p < 0.05). Before and after surgery, the mean calibration size was 12.76 F and 24.50 F, respectively (p < 0.05). Self-reported satisfaction score (Patient Global impression of improvement) showed that five (5) patients scored 1 (very much better), sixteen (16) patients scored 2 (much better) and three (3) patients scored 3 (a little better). Three women (12.5%) had stricture recurrence. Two of them got stabilised with initial soft dilatation, and the third women required continued self-catheterisation. Overall, the success rate was 87.5% with a mean (range) follow-up of 22.62 (12–36) months.

Conclusion
Dorsal onlay vaginal graft urethroplasty is a simple, safe and practical approach to treat female urethral stricture with a reasonable success rate. It can be considered as a first-line option for definitive repair.
Occurrence of a single-species cyanobacterial bloom in a lake in Cyprus: monitoring and treatment with hydrogen peroxide-releasing granules
Authors: Keliri Eleni , Paraskeva Christia , Sofokleous Angelos , Sukenik Assaf , Dziga Dariusz , Chernova Ekaterina , Brient Luc , Antoniou Maria G. 
Published: March 2021

AbstractBackgroundExcess loads of nutrients finding their way into waterbodies can cause rapid and excessive growth of phytoplankton species and lead to the formation of cyanobacterial harmful algal blooms (cyano-HABs). Toxic cyanobacteria produce a broad range of bioactive metabolites, some of which are known as cyanotoxins. These metabolites can negatively impact the ecosystem, and human and animal health, thus their presence needs to be closely monitored and mitigated. This study aimed to monitor St. George Lake (Athalassa National Forest Park, Cyprus) for its water quality characteristics, and initiate a new methodology to control the bloom that occurred in the lake during summer 2019, by comparing hydrogen peroxide treatment with novel metallic peroxide granules as source of hydrogen peroxide.ResultsLake monitoring showed that pH, salinity, total dissolved solids and conductivity varied throughout the year, and nutrients concentration was high, indicating a eutrophic lake. The cyanobacteriumMerismopediasp. bloomed in the lake between June and September 2019, comprising up to 99% of the phytoplankton biovolume. The presence of microcystin synthase encoding gene (mcyB, mcyE) was documented, however microcystins were not detected by tandem mass spectroscopy. Treatment with liquid hydrogen peroxide in concentrations 1 to 5 mg L−1had no effect on the phycocyanin fluorescence (Ft) and quantum yield of PSII (Fv/Fm) indicating an ineffective treatment for the denseMerismopediabloom (1 million cells mL−1 ± 20%). Metallic peroxide granules tested for their H2O2releasing capacity in St. George Lake water, showing that CaO2released higher H2O2concentration and therefore have better mitigation efficiency than MgO2granules.ConclusionThe present study highlights the importance of monitoring several water parameters to conclude on the different actions to be taken to limit eutrophication in the catchment area. The findings demonstrated that testing for the presence of genes involved in cyanotoxin production may not be sufficient to follow cyanotoxins in the water, therefore it should be accompanied with analytical confirmation. Treatment experiments indicated that slow release of H2O2from peroxide granules may be an alternative to liquid hydrogen peroxide when applied in appropriate doses, but further investigation is needed before it is applied at the field.Graphic Abstract
Transcriptomes analysis reveals novel insight into the molecular mechanisms of somatic embryogenesis in Hevea brasiliensis
Authors: Wang Ying , Li Hui-Liang , Zhou Yong-Kai , Guo Dong , Zhu Jia-Hong , Peng Shi-Qing 
Published: March 2021

AbstractBackgroundSomatic embryogenesis (SE) is a promising technology for plant vegetative propagation, which has an important role in tree breeding. Though rubber tree (Hevea brasiliensisMuell. Arg.) SE has been founded, few late SE-related genes have been identified and the molecular regulation mechanisms of late SE are still not well understood.ResultsIn this study, the transcriptomes of embryogenic callus (EC), primary embryo (PE), cotyledonary embryo (CE), abnormal embryo (AE), mature cotyledonary embryo (MCE) and withered abnormal embryo (WAE) were analyzed. A total of 887,852,416 clean reads were generated, 85.92% of them were mapped to the rubber tree genome. The de novo assembly generated 36,937 unigenes. The differentially expressed genes (DEGs) were identified in the pairwise comparisons of CE vs. AE and MCE vs. WAE, respectively. The specific common DEGs were mainly involved in the phytohormones signaling pathway, biosynthesis of phenylpropanoid and starch and sucrose metabolism. Among them, hormone signal transduction related genes were significantly enriched, especially the auxin signaling factors (AUX-like1,GH3.1,SAUR32-like,IAA9-like,IAA14-like,IAA27-like,IAA28-likeandARF5-like). The transcription factors includingWRKY40,WRKY70,MYBS3-like,MYB1R1-like,AIL6andbHLH93-likewere characterized as molecular markers for rubber tree late SE.CML13,CML36,CAM-7,SERK1andLEAD-29-likewere also related to rubber tree late SE. In addition, histone modification had crucial roles during rubber tree late SE.ConclusionsThis study provides important information to elucidate the molecular regulation during rubber tree late SE.
Long-term impact of baseline serum uric acid levels on living kidney donors: a retrospective study
Authors: Tanaka Kosuke , Yamanaga Shigeyoshi , Hidaka Yuji , Nishida Sho , Kinoshita Kohei , Kaba Akari , Ishizuka Toshinori , Hamanoue Satoshi , Okumura Kenji , Kawabata Chiaki , Toyoda Mariko , Miyata Akira , Kashima Masayuki , Yokomizo Hiroshi 
Published: March 2021

AbstractBackgroundPreoperative characteristics of living kidney donors are commonly considered during donor selection and postoperative follow-up. However, the impact of preoperative uric acid (UA) levels is poorly documented. The aim of this study was to evaluate the association between preoperative serum UA levels and post-donation long-term events and renal function.MethodsThis was a single-center retrospective analysis of 183 living kidney donors. The donors were divided into high (≥5.5 mg/dl) and low (< 5.5 mg/dl) UA groups. We analyzed the relationship between preoperative UA levels and postoperative estimated glomerular filtration rate (eGFR), as well as adverse events (cardiovascular events and additional prescriptions for hypertension, gout, dyslipidemia, and diabetes mellitus), over 5 years after donation.ResultsIn total, 44 donors experienced 52 adverse events over 5 years. The incidence of adverse events within 5 years was significantly higher in the high UA group than in the low UA group (50% vs. 24%,p = 0.003); this was true even after the exclusion of hyperuricemia-related events (p = 0.047). UA emerged as an independent risk factor for adverse events (p = 0.012). Donors with higher UA levels had lower eGFRs after donation, whereas body mass index, hemoglobin A1c, blood pressure, and low-density lipoprotein cholesterol did not have any impact on the eGFR.ConclusionsThe findings suggest that preoperative UA levels should be considered during donor selection and postoperative follow-up.
Fertility outcomes in women after controlled ovarian stimulation with gonadotropin releasing hormone agonist long protocol: fresh versus frozen embryo transfer
Authors: Ding Xiaoyan , Yang Jingwei , Li Lan , Yang Na , Lan Ling , Huang Guoning , Ye Hong 
Published: March 2021

Abstract
Background
Along with progress in embryo cryopreservation, especially the vitrification, freeze all strategy has become more acceptable than ever. Some studies have found comparable or higher live birth rate with frozen embryo transfer (FET) than with fresh embryo transfer(ET)in gonadotropin releasing hormone antagonist (GnRH-ant) protocol. However from our literature research, there have been no reports about live birth rate comparison between fresh ET and FET with gonadotropin releasing hormone agonist (GnRH-a) long protocol. The aim of this study is to retrospectively investigate whether patients benefit from freeze all strategy in GnRH-a protocol using real-world data.

Methods
This is a retrospective cohort study, in which women undergoing fresh ET or FET with GnRH-a long protocol at Chongqing Reproductive and Genetics Institute from January 2016 to December 2018 were evaluated. The primary outcome was live birth rate. The secondary outcomes were implantation rate, clinical pregnancy rate, pregnancy loss and ectopic pregnancy rate.

Results
A total of 7,814 patients met inclusion criteria, implementing 5,216 fresh ET cycles and 2,598 FET cycles, respectively. The demographic characteristics of the patients were significantly different between fresh ET and FET groups, except BMI. After controlling for a broad range of potential confounders including age, infertility duration, BMI, AMH, number of oocytes retrieved and of available embryos, multivariate logistic regression analysis demonstrated that there was no significant difference in clinical pregnancy rate, ectopic pregnancy rate and pregnancy loss rate between two groups (all P > 0.05). However, the implantation rate and live birth rate in fresh ET group were significantly higher than FET group (P < 0.001 and P = 0.012, respectively).

Conclusions
Under GnRH-a long protocol, compared to FET, fresh ET was associated with higher implantation rate and live birth rate in infertile patients that underwent in vitro fertilization (IVF). The freeze all strategy should be individualized and made with caution especially with GnRH-a long protocol.