bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Experimental study and numerical simulation of uniaxial compression on artiﬁcial rock samples with Z-shaped fractures
Authors: Zhou Tao , Chen Haijun , Xiong Liangxiao , Xu Zhongyuan , Yang Jie , Xue Maolin , Deng Licheng 
Published: April 2021

Abstract
To study the influence of the inclination and length of Z-shaped fissures on the mechanical properties and failure characteristics of the rock mass, this study conducts a series of uniaxial compression tests on rock-like materials with prefabricated Z-shaped fractures. In addition, two-dimensional Particle Flow Code software is used to perform uniaxial compression numerical simulations. The results show that when the specified inclination angle γ (γ = 0°, 30° or 45°) of the parallel cracks on both sides remains unchanged, the peak strength and elastic modulus of the sample show an M-shaped change trend with an increase in the inclination angle β of the middle connection crack. When γ = 60° or 90°, however, the peak strength and elastic modulus of the sample show a trend of decreasing, increasing, and then decreasing as β increases. In addition, the peak strength and elastic modulus of the sample decrease with an increase in the crack length. The influence of crack length on the elastic modulus is less than that of compressive strength. Further, the main failure mode of specimens with Z-shaped cracks is determined to be tension–shear mixed failure manifested by crack propagation from the tip of the prefabricated crack to the upper and lower boundaries of the sample. As a result, a through failure surface is formed with the prefabricated crack, which destroys the sample.
Prognostic Nomograms for Predicting Overall Survival and Cancer-Specific Survival in Patients with Angiosarcoma, a SEER population-based study
Authors: Jiang Ting , Ye Zixiang , Shao TianYu , Luo YiYang , Wang BinBin 
Published: April 2021

Abstract
Backgrounds: Angiosarcoma (AS) is a kind of highly aggressive cancer with high occurrence and mortality rates. This study aimed to establish a comprehensive and validated prognostic nomogram with various clinical indicators in patients with AS.Methods: Data of patients with AS diagnosed after surgery between 2010 and 2015 was retrieved from the Surveillance Epidemiology and End Results (SEER) database. Univariate and multivariate Cox proportional hazards regression analysis were performed to identify the independent prognostic factors associated with survival to construct the predictive nomogram of 3- and 5-year overall survival (OS) and cancer-specific survival (CSS) rates. Concordance-index(C-index), calibration plots and receiver operating characteristic (ROC) curves were applied to evaluate the predictive ability of the nomograms. The further decision curve analysis (DCA) was drawn to confirm the clinical usefulness of the nomograms.Results: 323 patients in total with AS were divided into the training group (N =226) and the validation group (N = 97). After the multivariate Cox regression analysis, gender, age, AJCC stage group 7th ed, T, N and M stage 7th ed, histologic grade and primary site were statistically identified as independent factors with OS and CSS (P<0.05). The C-index of the nomograms for OS and CCS in the training cohort was 0.760 (95%CI: 0.674–0.847) and 0.793 (95%CI: 0.687–0.898), meanwhile, the C-index of those in the validation cohort was 0.790 (95%CI: 0.725–0.855) and 0.888 (95%CI: 0.799–0.976) respectively. The results of calibration plots and ROC curve showed the nomograms qualified to measure the risk and prognosis. DCA exhibited good clinical utility of nomograms.Conclusion: Our study has developed novel and practical nomograms for predicting prognosis in patients with AS contributing to cancer management.
Long-term Prognostic Outcomes in Patients With Hemoptysis
Authors: Mondoni Michele , Carlucci Paolo , Cipolla Giuseppe , Pagani Matteo , Tursi Francesco , Fois Alessandro , Pirina Pietro , Canu Sara , Gasparini Stefano , Bonifazi Martina , Marani Silvia , Comel Andrea Claudio , Saderi Laura , De Pascalis Sabrina , Alfano Fausta , Centanni Stefano , Sotgiu Giovanni 
Published: April 2021

Abstract
Background: Hemoptysis is a challenging symptom which can be associated with potentially life-threatening medical conditions. Follow-up is key in these patients to early detect new or misdiagnosed pathologic findings. Few prospective studies evaluated long-term prognostic outcomes. Furthermore, the role played by antiplatelet and anticoagulant drugs on mortality and recurrence rates is unclear.The aim of the study was to assess the mortality after 18 months of follow-up; furthermore, it was evaluated the incidence of recurrences and the factors associated with both recurrence and death (including the role played by anticoagulant and antiplatelet drugs).Methods: Observational, prospective, multicentre, Italian study.Results: 451/606 (74.4%) recruited patients with hemoptysis completed the 18 months follow-up.22/604 (3.6%) diagnoses changed from baseline to the end of the follow-up. 83/604 (13.7%) patients died. In 52/83 (62.7%) patients, death was the outcome of the disease which caused hemoptysis at baseline. Only the diagnosis of lung neoplasm was associated with death (OR (95%CI): 38.2 (4.2-347.5); p-value: 0.0001).166 recurrences were recorded in 103/604 (17%) patients. The diagnosis of bronchiectasis was significantly associated with the occurrence of a recurrence (OR (95% CI): 2.6 (1.5-4.3)); p-value <0.0001).Anticoagulant, antiaggregant, and anticoagulant plus antiaggregant drugs were not associated with an increased risk of death and recurrence.Conclusions: Our study showed a low mortality rate in patients with hemoptysis followed-up for 18 months. Pulmonary malignancy is the main etiology and the main predictor of death, whereas bronchiectasis is the most frequent diagnosis associated with recurrence. Antiplatelet and/or anticoagulant therapy do not change the risk of death or recurrence. Follow-up is recommended in patients initially diagnosed with lower airways infections and idiopathic bleedings.Clinical trial registration: NCT02045394.
Regime Transition Shapes the Composition, Assembly Processes and Co-Occurrence Pattern of Bacterioplankton Community in a Large Eutrophic Freshwater Lake
Authors: Cao Xinyi , Zhao Dayong , Röttjers Lisa , Faust Karoline , Zhang Hongjie 
Published: April 2021

Abstract
At certain nutrient concentrations, shallow freshwater lakes are generally characterized by two contrasting ecological regimes with disparate patterns of biodiversity and biogeochemical cycles: a macrophyte-dominated regime (MDR) and a phytoplankton-dominated regime (PDR).To reveal ecological mechanisms that affect bacterioplankton along the regime shift, Illumina MiSeq sequencing of the 16S rRNA gene combined with a novel network clustering tool (Manta) were used to identify patterns of bacterioplankton community composition across the regime shift in Taihu Lake, China. Marked divergence in the composition and ecological assembly processes of bacterioplankton community were observed under the regime shift. The alpha diversity of bacterioplankton community was observed to consistently and continuously decrease with the regime shift from MDR to PDR, while the beta diversity presents the opposite. Moreover, as the regime shifted from MDR to PDR, the contribution of deterministic processes first decreased and then increased again closer to the PDR, most likely as a consequence of differences in nutrient concentration. The topological properties of bacterioplankton co-occurrence networks along the regime shift differed, and the co-occurrences among species changed in structure and were significantly shaped by the environmental variables along the regime transition from MDR to PDR. The divergent environmental state of the regimes with diverse nutritional status may be the most important factor that contributes to the dissimilarity of bacterioplankton community composition along the regime shift and could be represented by phosphorus concentrations as well as several indicator species.
Effects of Telerehabilitation on Occupational Therapy Services in the Coronavirus Disease 2019 Era: An Umbrella and Mapping Review with Meta–Meta-Analysis
Authors: Alageel Sara Mohammad 
Published: April 2021

Abstract
PurposeTelerehabilitation (TR) is a medical option that should be embraced in contemporary society to curb the spread of coronavirus. An umbrella along with mapping review based on a meta-meta-analysis (MMA) has recently been conducted using available scientific revelations to establish whether TR could be a critical option for traditional rehabilitation systems in occupational therapy practices [1].MethodsA systematic review of reviews along with previous and current studies on the objectives and systematic evidence based on an MMA and visual maps was conducted. A systematic search was then initiated in the Google Scholar, MEDLINE (PubMed), and Cochrane Database of Systematic Reviews (CDSR). Accordingly, two independent reviewers scrutinized and examined all obtained data and simultaneously analysed the authenticity of the reviews included while evaluating the bias risks using ROBIS. ResultsTwenty-five articles that met the inclusion thresholds were selected and grouped based on the conditions of the patients on rehabilitation, which constituted musculoskeletal, cardiorespiratory, and neurological conditions. The MMA linked to occupational functioning between normal care rehabilitation and TR failed to indicate a statistical difference among patients with musculoskeletal and cardiorespiratory conditions [2]. The MMA showed statistically significant results among patients with neurological conditions but with negligible impacts in six reviews on TR. The standardized mean difference was 0.18 with a 95-confidence interval of 0.03–0.34.ConclusionThese results suggest that TR provides admirable results that in many ways can be compared with face-to-face rehabilitation processes.ImpactTR has the advantage of reducing costs that work along with its minimal interruptions on a patient’s contemporary interactions, suggesting that it helps current medical setups when society requires minimal interactions to curb the spread of coronavirus.
Heat source-free water-floating carbon nanotube thermoelectric generators
Authors: Chiba Tomoyuki , Amma Yuki , Takashiri Masayuki 
Published: April 2021

Abstract
Thermoelectric generators (TEGs) produce electric power from environmental heat energy and are expected to play a key role in powering the Internet of things. However, they require a heat source to create a stable, irreversible temperature gradient. Overcoming these restrictions will allow the use of TEGs to proliferate. To this end, we propose heat source-free water-floating carbon nanotube (CNT) TEGs. Here, thermopower is generated by the temperature gradient in the CNT films in which water pumping via capillary action leads to water evaporation-induced cooling occurs in selected areas. Furthermore, the thermoelectric power increases when the films are exposed to sunlight and wind flow. These water-floating CNT TEGs demonstrate a pathway for developing wireless monitoring systems for water environments.
SHP-2 deletion in CD4+ chondrocyte precursors leads to tumor development with wrist tropism
Authors: Brossay Laurent , McNamara Jeffrey , Huntington Kelsey , Borys Samantha , Jayasuriya Chathuraka 
Published: April 2021

Abstract
Due to redundancy with other tyrosine phosphatases, the ubiquitously expressed tyrosine phosphatase SHP-2 (encoded by Ptpn11) is not required for T cell development. However, Ptpn11 gene deletion driven by CD4 Cre recombinase leads to cartilage tumors in the wrist. Using a fate mapping system, we demonstrate that wrist tumor development correlates with increased frequency and numbers of non-hematopoietic CD45 negative cells with a bone chondrocyte stromal cell precursor cell (BCSP) phenotype. Importantly, the BCSP subset has a history of CD4 expression and a marked wrist location tropism, explaining why the wrist is the main site of tumor development. Mechanistically, we found that in SHP-2 absence, SOX-9 is no longer regulated, leading to an uncontrolled proliferation of the BCSP subset. Altogether, these results identify a unique subset of chondrocyte precursors tightly regulated by SHP-2. These findings underscore the need for the development of methods to therapeutically target this subset of cells, which could potentially have an impact on treatment of SHP-2 dysfunction linked debilitating diseases.
Comparison of Insertion Time, Pull-out Strength, and Screw-media Interface Area of Customized Pedicle Screw With Different Core and Thread Design Against Commercial Pedicle Screw
Authors: Magetsari Rahadyan , Rukmoyo Tedjo , Saputra Marda Ade , Sakti Yudha Mathan 
Published: April 2021

Abstract
Objective: This research aimed to developing customized pedicle screw based on Indonesian vertebral anatomy and compare the insertion time, pull-out strength, and screw-media interface area of different screw design. We have developed 3 different types of pedicle screws (v-thread cylinder-core, square-thread cylinder-core and square-thread conical-core). The thread diameter was calculated from pedicle width of Indonesian population (6 mm). We used commercially available pedicle screw as control group (6.2 mm). Result: The insertion time were significantly difference between v-thread cylinder-core pedicle screw (22,94 s) with commercially available pedicle screw (15.86 s) (p<0.05). The pull-out strength was significantly difference between commercially available pedicle screw (408.60 N) with square-thread conical pedicle screw (836.60 N) (p<0.05). The square-thread conical-core group have the highest interface area (1486.21 mm2). The data comparison showed that the square-thread conical-core customized pedicle screw group has comparable insertion time and has better pull-out strength than commercially available pedicle screw.
Impacts of Parental Technoference on Parent-Child Relationships and Child Health and Developmental Outcomes: A Scoping Review Protocol
Authors: MacKay Lyndsay Jerusha , Komanchuk Jelena , Hayden K. Alix , Letourneau Nicole 
Published: April 2021

Abstract
Background: With increases in the use of technological devices worldwide, parental technoference is a potential threat to quality of parent-child relationships and children’s health and development. Parental technoference refers to disrupted interactions between a parent and child due to a parent’s use of a technological device. The aim of this scoping review is to map, describe and summarize existing evidence from published research studies on the impacts of parental technoference on parent-child relationships and children’s health and development and to identify limitations in the studies and gaps in the literature. Methods: This scoping review will be conducted in accordance with the Joanna Briggs Institute (JBI) methodology. A search for relevant research studies will be undertaken in APA PsycInfo, MEDLINE, Central, Cochrane Database for Systematic Reviews, JBI EBP and Embase (OVID). CINAHL (Ebsco) and Scopus will also be searched. Grey and popular literature will be excluded. This review will include primary research studies and review papers published in English with no time limit that identify the impacts of technoference on parent-child relationships and child health and developmental outcomes. Parent participants include primary caregivers, either biological, adopted or foster parents, of children under the age of 18 who engage in technoference. Two reviewers will independently screen titles, abstracts and full texts of studies according to inclusion and exclusion criteria. Disagreements will be resolved through discussion with a third researcher. Data will be extracted into a data charting table including; author(s), year of publication, country, research aim, methodology/design, population and sample size, variables/concepts and corresponding measures and main results. Data will be presented in tables and figures accompanied by a narrative summary. Discussion: The goal of this scoping review is to present an overview of the evidence on impacts of parental technoference on parent-child relationships and child and health developmental outcomes, highlighting the current risk of children of today. It will identify gaps in the literature, inform future research, advise recommendations for parents on technological device use and possibly guide the development of interventions aimed at addressing parental technoference. Systematic review registration: Open Science Framework (10.17605/OSF.IO/QNTS5)
Bcl-2-associated Transcription Factor 1 Phosphorylation Mediated DNA Damage Response in Gastric Cancer
Authors: Liu Jia , Li Jingyi , Sun Zhao , Duan Yangmiao , Wang Fengqin , Wei Guangwei , Yang Jing-Hua 
Published: April 2021

Abstract
Background: DNA damage response plays critical roles in tumor pathogenesis and radiotherapy resistance. Various cellular activities including the initiation and major steps DNA damage response are regulated by protein phosphorylation, whereas the molecular mechanism remains largely unknown. Methods: A quick label-free phosphoproteomics using high-resolution mass spectrometry and an open search approach was applied to paired tumor and adjacent tissues from five patients with gastric cancer. The dysregulated phosphoproteins were identified and their associated-pathways analyzed using Gene Set Enrichment Analysis (GSEA). The mostly regulated phosphoproteins and their potential functions were validated by the specific antibodies against the phosphorylation sites. Specific protein phosphorylation was further analyzed by functional and clinical approaches. Results: 832 gastric cancer-associated unique phosphorylated sites were identified, among which 25 were up- and 52 down-regulated. Markedly, the dysregulated phosphoproteins were primarily enriched in DNA-damage-response-associated pathways. Particularly, the phosphorylation of Bcl-2-associated transcription factor 1 (BCLAF1) at Ser290 was significantly upregulated in tumor. The upregulation of BCLAF1 Ser290 phosphorylation (pBCLAF1(Ser290)) in tumor was confirmed by tissue microarray studies and further indicated in association with poor prognosis of gastric cancer patients. Eliminating the phosphorylation of BCLAF1 at Ser290 suppressed gastric cancer (GC) cell proliferation. Upregulation of pBCLAF1(Ser290) was found in association with irradiation-induced γ-H2AX expression in the nucleus, leading to an increased DNA damage repair response, and a marked inhibition of irradiation-induced cancer cell apoptosis. Conclusions: The phosphorylation of BCLAF1 at Ser290 is involved in the regulation of DNA damage response, indicating an important target for the resistance of radiotherapy.
Does Demography &amp; Socio-Economic Status Influence Investment Motives?
Authors: K Riyazahmed 
Published: April 2021

Abstract
Research studies in the past have analyzed the significance of demographic and socioeconomic status influencing investment preference and behavior. However, no study has focused on analyzing their impact on ‘Investment motives’. Hence, this study examines the investment motives and analyzes the significance of the impact of demographic and socioeconomic factors on investment motives. The study uses factor analysis and Multivariate analysis of variance (MANOVA) for this purpose. The data are collected from 753 investors through a structured questionnaire. Results of the study show that investment motives are grouped into six categories i.e., nature of the investment, future financial needs, investor characteristics, safety and stability, investor behavior, and investor options. Further, there exists a main effect of employment, marital status, location, and the number of earning members on investment motives. Likewise, there exists an interaction effect of age and location, gender and income, and age and income on investment motives. The study adds to the existing literature by comprehensively analyzing all the demographic, socioeconomic status with the investment motives.
Attribute Based Collusion Resistant Controlled Secure Data Processing System Using Node Insertion Method
Authors: P. Dhanalakshmi , S Rajarajeswari , Das Nripendra Narayan , C Karthikeyan , Reddy L. Chandra Sekhar , Jain Parita 
Published: April 2021

Abstract
In the fast-developing technological world, a large number of informational data is obtained out of different software applications and hardware sources. Data storing, sharing of data, and then processing is more effective through the cloud computing method. In practice, the issue faced is a lack of security where the user details are leaked due to the exposure of software and hardware conflict. Among different data sharing technique, cloud computing is the most convenient method to be adapted due to service satisfying features and economy. Attribute-Based-Encryption (ABE) has the potential to detect even a narrow-drawn data sharing. The drawback of the conventional attribute-based encryption (ABE) poor data security and high over-head computation. The customer side satisfaction is not achieved because of security lacking in narrow-drawn informational data sharing as well as processing. The difficulty in achieving a standardized form of data sharing is an unsolved challenge for secured data processing. The attribute-based data sharing method is more effective for secured data processing in cloud computing. Customer satisfaction can be achieved through the secured services of cloud. The customer’s data should be secured and also the customer’s data is under an authorized access. The protection of data in cloud computing includes the usage of hardware solutions for a secured data operation, provides support in data storage, access, sharing, and automated detecting of risk during data processing.