bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repenser les partenariats entre écoles primaires et secteurs de psychiatrie infanto-juvénile en temps de COVID-19
Authors: Bonneton Sandrine , Maillard Isabelle , Denis Frédéric , Roelandt Jean-Luc 
Published: March 2021

Introduction : À échelle mondiale, le rapprochement entre écoles et services publics de pédopsychiatrie est privilégié pour promouvoir le développement d’interventions précoces qui améliorent les trajectoires de santé, de la prévention jusqu’aux soins des enfants exposés à des difficultés d’ordre psychique. Dans une perspective de santé publique, la contextualisation de ces pratiques est primordiale pour assurer leur pérennisation et leur efficacité. Cet article propose un éclairage sur les enjeux de ces rapprochements et les avantages de ces derniers pour répondre à l’empreinte sanitaire, sociale et économique de la crise liée à l’arrivée brutale de l’épidémie de Covid-19. Objectifs : Améliorer la prise en charge des enfants présentant des problèmes de santé mentale ou d’ordre psychique renvoie à une prise en compte de leur environnement au-delà du cadre thérapeutique. Une recherche interventionnelle, en cours actuellement, engage sur plusieurs sites en France : écoles primaires, Centres médico-psychologiques (CMP) et Conseils locaux en santé mental (CLSM). Elle a pour but d’inventorier et d’analyser les cadres partenariaux et interventionnels les plus efficients, à partir des besoins et des ressources mobilisables de chaque site. Elle envisage une diversification et une contextualisation de l’offre de soins dans un souci d’équité et d’efficacité thérapeutique à partir de l’école. Résultats : Plus que de résultats, il s’agit de faire des propositions pour accompagner au mieux la sortie de confinement et les mois à venir. Le déploiement de partenariats sur les territoires fortement marqués par les inégalités sociales et économiques constitue une priorité en termes de santé publique et d’orientation des politiques locales. Ces partenariats pourraient participer d’une stratégie globale d’évaluation des besoins et d’accompagnement personnalisé des enfants. La formalisation d’interventions à l’interface école-secteur permettrait d’étayer les professionnels de l’école à surmonter cette crise sanitaire qui traverse leur institution, afin qu’elle ne se cristallise pas en son sein. La montée en puissance des CLSM permettrait d’amplifier les coordinations et les collaborations locales pour aider les enfants les plus vulnérables psychiquement et accompagner leurs parents, compte tenu de leur situation, à soutenir le développement de ces derniers. Conclusion : Redonner les moyens humains et matériels aux structures existantes, notamment au secteur de psychiatrie infanto-juvénile, afin qu’il puisse remplir ses missions de service public semble une priorité aujourd’hui. La mise en œuvre de partenariats école-CMP-CLSM peut contribuer à l’orientation de politique locale dans un souci d’élaborer des stratégies individuelle et collective, qui garantissent des soins adaptés aux besoins des enfants et accessibles au plus grand nombre.
Facteurs d’adhésion et utilisation des Mutuelles de Santé (MS) : région Ziguinchor au Sénégal
Authors: Sow Papa Gallo , Bop Martial Coly , Akoetey Kossivi , Diop Cheikh Tacko , Kâ Ousseynou 
Published: March 2021

But : l’objectif de cette étude était d’identifier les facteurs qui expliquent l’adhésion et l’utilisation des Mutuelles de santé (MS) et de formuler des recommandations d’actions qui permettraient d’inciter la population à la base à adhérer davantage aux MS dans la Région de Ziguinchor au Sénégal. Méthode : l’échantillon était constitué de 392 patients sélectionnés par la méthode des quotas dans les centres hospitaliers de la Région. Les données ont été traitées et analysées par les logiciels sphinx et stata et par la méthode de régression logistique. Résultats : les facteurs qui expliqueraient l’adhésion et l’utilisation des MS dans la région d’étude étaient : la perception, la présence d’une personne âgée dans le ménage, la confiance accordée au MS, la taille des ménages et la pyramide médicale instaurée.
Fréquence des grossesses en milieu scolaire et profil des adolescentes concernées à Conakry, Guinée
Authors: Sidibé Sidikiba , Grovogui Fassou Mathias , Millimouno Tamba Mina , Camara Bienvenu Salim , Bouédouno Patrice , Kourouma Karifa , Camara Gnoumé , Tounkara Adrien Fapeingou , Delamou Alexandre 
Published: March 2021

Introduction : La grossesse en milieu scolaire constitue un frein à l’épanouissement et à l’éducation des jeunes filles surtout dans les Pays en développement. Le but de cette étude était d’analyser la fréquence des grossesses en milieu scolaire et le profil des adolescentes ayant fait l’expérience dans la ville de Conakry en Guinée. Méthode : Nous avons mené une étude transversale couvrant la période du 1 er janvier au 30 juin 2017 dans 16 écoles. Résultats : Au total, 2 419 adolescentes ont accepté de participer à l’étude. L’âge moyen était de 16,48±0,04 ans. Les élèves âgées de 15 à 19 ans (93 %), celles qui étaient au collège (53,3 %) et les célibataires (69,8 %) étaient les plus nombreuses à avoir été enceintes en milieu scolaire ( p < 0,05). Selon nos statistiques, les facteurs significativement associés à la survenue des grossesses chez les adolescentes en milieu scolaire étaient : l’âge (Rapport de côtes ajusté (RCa)=1,5 ; IC95 %=1,3-1,7 p < 0,001), le niveau d’étude (RCa = 0,6 ; IC95 % = 0,4-0,8 ; p = 0,003 pour le lycée), le lieu de résidence (RCa = 0,5 ; IC95 % = 0,4-0,9 ; p = 0,002 pour Matam, RCa = 0,4 ; IC95 % = 0,3-0,8 ; p < 0,001 pour Dixinn, RCa = 0,3 ; IC95 % = 0,2-0,8 ; p = 0,010 pour Ratoma), la situation matrimoniale (RCa = 8,7 ; IC95 % = 3,4-7,0 ; p < 0,001), les informations sur la santé de la reproduction (RCa = 2,4 ; IC95 % = 1,1-3,0 ; p = 0,015), la connaissance des avantages de la planification familiale (RCa = 2,2 ; IC95 % = 1,0-2,2 ; p = 0,030) et la difficulté d’accès aux services de santé sexuelle et reproductive (RCa = 3,4 ; IC95 % = 1,4-3,7 ; p < 0,01). Conclusion : La survenue des grossesses en milieu scolaire demeure une réalité préoccupante chez les adolescentes. Les facteurs qui y sont positivement associés sont l’âge, le niveau d’étude, le lieu de résidence, la situation matrimoniale, la connaissance des informations sur la santé sexuelle, la connaissance des avantages de la planification familiale et les difficultés liées à l’accès aux services de santé sexuelle et reproductive.
High School Students' Perceptions of Nursing as a Career: A Pilot Study
Authors: Grossman Divina , Arnold Lauren , Sullivan Jacqueline , Cameron Mary Emily , Munro Barbara 
Published: March 2021

ABSTRACT
A pilot survey of 300 high school junior students was implemented to elicit their perceptions of nursing and to explore the relationship between the experience of having a nursing role model and the decision to consider nursing as a career. The results indicated that the majority of students in the sample were aware of the caring and helping aspects of nursing, but there seemed to be a lack of knowledge about expanded roles and opportunities for advancement. High school students had significantly different mean opinion scores according to their sex (F = 17.03, p<0001) and the decision to consider nursing as a career (F = 10.00, p<002). There appeared to be a significant relationship between the experience of having a nurse role model and consideration of nursing as a career option (X2 = 8.23, p<.0041). These findings have important implications for recruitment of young people into the nursing profession.
Le compostage, entre réduction des déchets et domestication du pourrissement
Authors: Granjou Céline , Higgin Marc , Mounet Coralie 
Published: March 2021

Dans la ville de Grenoble et ses environs, comme dans de nombreuses autres villes et collectivités confrontées à la forte augmentation des déchets ménagers, le compostage est promu afin de réduire la quantité des déchets à traiter. Sur la base d’une enquête empirique auprès des praticiens et des techniciens du compostage à Grenoble et dans ses environs, l’article interroge les enjeux de la promotion du compostage privé. Il montre que ce qui est en jeu pour les praticiens du compostage, au-delà d’une adhésion aux normes de tri et de réduction des déchets, c’est surtout l’introduction, dans l’ordre ménager et domestique, d’une série de savoir-faire, de savoir-voir et d’expérimentations situées visant à évaluer et stimuler les mécanismes de décomposition et de pourrissement qui prennent place dans les composts. Cet article propose ainsi de montrer comment le compostage introduit un nouveau rapport aux déchets, interrogeant leur statut même de déchet : les restes de notre consommation cessent d'être de simples « détritus » dont on doit se débarrasser, pour devenir une matière dont la capacité productive est « domestiquée », mais jamais totalement contrôlée.
Prevalence of aspergillus skin hypersensitivity in allergic rhinitis
Authors: Bansal Monika , Kaur Komaldeep , Gupta Aditi , Goyal Deepak , Girdhar Nidhi , Chopra Vishal , Bhagat Sanjeev , Goel Akhil D. 
Published: March 2021

Allergic rhinitis (AR) is a chronic allergen specific, IgE-mediated hypersensitivity disorder which significantly impairs the quality of life in affected patients. Many aeroallergens and molds are responsible for AR. This study was conducted to find prevalence of Aspergillus fumigatus skin hypersensitivity in patients of AR by skin prick test (SPT). 150 clinically diagnosed AR patients visiting our OPD were enrolled. Skin hypersensitivity for Aspergillus f. was done by SPT in all the enrolled patients. Chi square test and Studentâ€™s t-test were applied for statistical analysis. Out of 150 patients, 60 (40%) were positive for Aspergillus fumigatus SPT. Majority of the positive patients had persistent AR and among those 39/60 (65%) had moderate to severe persistent AR and 12/60 (20%) had mild persistent AR. Our study concluded that there is high (40%) prevalence of Aspergillus f. skin hypersensitivity among AR patients. The hypersensitivity to Aspergillus f. was found more in severe AR patients and it was statistically significant.
Chest CT features of patients under investigation for Covid-19 pneumonia in a Ghanaian tertiary hospital: a descriptive study
Authors: Dzefi-Tettey Klenam , S. Saaka Patience , Acquah Isaac , K. M. Edzie Emmanuel , N. Gorleku Philip , Adjei Patrick , K. Semetey Jonathan , K. D. Ayem Edward , J. Insaidoo Arwen , Samba Ali 
Published: March 2021

Background: Coronavirus disease 2019 (COVID-19) has since December 2019 become a problem of global concern. Due to the virus’ novelty and high infectivity, early diagnosis is key to curtailing spread. The knowledge and identification of chest Computerized Tomography (CT) features in Patients Under Investigation (PUI) for the disease would help in its management and containment.
Objectives: To describe the chest CT findings of PUI for COVID-19 pneumonia referred to the Department of Radiology of the Korle Bu Teaching Hospital; as well as to determine the relationship between symptom onset and severity of the chest CT findings.
Methods: The study was retrospective and included 63 PUI for COVID-19 referred to the Department between 11th April, 2020 and 10th June, 2020, for non-enhanced chest CT imaging. Clinical data were obtained from patients’ records and Reverse Transcriptase–Polymerase Chain Reaction (RT-PCR) results were acquired after the CT evaluation.
Results: The mean age in years was 51.1±19.9 SD. More males (52.8%) than females (47.2%) tested positive for COVID-19 and the age range for positive cases was 7 months to 86 years, with a mean of 53.2±21 SD years. Common features of COVID-19 pneumonia were bilateral posterior basal consolidations, Ground Glass Opacities (GGO) and air bronchograms. Findings were worse in patients scanned 5–9 days after onset of symptoms.
Conclusion: Adequate knowledge of chest CT features of COVID-19 pneumonia, proves a valuable resource in triaging of symptomatic patients and consequent containment of the disease in the hospital setting.
Antifungal Properties of Protein Extracts from Thai Medicinal Plants to Opportunistic Fungal Pathogens
Authors: JEENKEAWPIEAM Juthatip , YODKEEREE Supachai , ROYTRAKUL Sittiruk , PONGPOM Monsicha 
Published: March 2021

Antifungal proteins or peptides (AFPs) are the natural products produced by several life forms including plants as the first-line defenses to infections. The AFPs from Thai plants can be used as new therapeutic agents in the world with growing resistance to conventional antifungals. This study determined the antifungal activities of protein extracts from Thai medicinal plants against important human opportunistic fungi, Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, and Talaromyces marneffei. Total crude protein supernatants and their precipitated proteins from 10 Thai medicinal plants with the historical usage for treatment of fungal infection were prepared. Most of the protein extracts showed antifungal activities to the tested fungi. The most effective reactivity found in the extracts from Rhinacanthus nasutus, Andrographis paniculata, and Psidium guajava by showing highest activity to T. marneffei ATCC200051 (yeast phase), followed by C. neoformans ATCC90112, C. albicans ATCC90028, T. marneffei ATCC200051 (mold phase), and A. fumigatus NCPF7367. The precipitated proteins from R. nasutus and A. paniculata containing antifungal properties were selected for partial purification by size cut-off membrane centrifugation and tested for antifungal activities. A colorimetric broth microdilution method was used to determine the minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) to anti-T. marneffei. The partially purified fractions from A. paniculata, and R. nasutus showed anti-T. marneffei activity with the MIC and MFC values ranged from 2 to 128 μg/mL and 16 to >128 μg/mL, respectively. Therefore, A. paniculata and R. nasutus can be further subjected to the study of the therapeutic antifungals.
The prognostic impact of CD49d protein and mRNA
expression in patients with chronic lymphocytic
leukaemia
Authors: Putowski Maciej , Skórka Katarzyna , Włodarczyk Monika , Tomczak Waldemar , Subocz Edyta , Hałka Janusz , Giannopoulos Krzysztof 
Published: March 2021

IntroductionThis research aimed to study CD49d expression – a potential
prognosis marker in chronic lymphocytic leukaemia (CLL) patients – at the
protein and mRNA levels. It was analysed in terms of time to first treatment
and compared to currently known prognostic markers and novel molecular
markers.Material and methodsUsing samples from 199 newly diagnosed CLL patients, we conducted immunophenotypical analyses of CD49d with flow cytometry, and assessed its expression on the mRNA level using quantitative
polymerase chain reaction (PCR).ResultsCytometric analysis showed significantly higher expression of
CD49d protein in ZAP-70+ (cut-off of 20%) patients than that in ZAP-70
patients (18.52 vs. 6.57, p = 0.028), and a tendency of higher CD49d expression in CD38+ patients than in CD38 patients (20.48 vs. 7.25, p = 0.072).
CD49d expression significantly correlated with serum β2-microglobulin
(r = 0.273, p = 0.012) and lactate dehydrogenase activity (r = 0.159,
p < 0.01). Analysed in subgroups divided according to novel mutations,
CD49d expression showed a tendency to be higher in MUT SF3B1 (93.98 vs.
7.86, p = 0.06) and MUT NOTCH1 (18.52 vs. 7.86, p = 0.140) groups than in
the corresponding UNMUT groups. CD49d expression did not affect the time
to first treatment at protein or mRNA level.ConclusionsHigh CD49d expression at the protein level accompanies aggressive biological markers in CLL patients, indicating its prognostic potential. It can thus be used to identify patients with poor clinical CLL prognosis.
Síndrome de malabsorción por disgammaglobulinemia y alteraciones en inmunidad celular
Authors: Chaves B María Gabriela , Hevia Urrutia Francisco , Frajman L Mauricio 
Published: March 2021

Los síndromes de malabsorción constituyen una entidad compleja de etiopatogenia multifactorial. Clásicamente se describe el sprue tropical, entidad con predisposición genética…
El esquema de vacunación de Costa Rica
Authors: Porras Madrigal Oscar 
Published: March 2021

El sistema de salud de Costa Rica ofrece un esquema de vacunación amplio, técnicamente diseñado, basado en evidencia y apoyado en literatura y recomendaciones internacionales. Estas guías que ofrece Acta Médica Costarricense permiten al médico o al personal de salud que aplica vacunas una orientación sobre edad de aplicación, dosis, vía de aplicación y refuerzos producto del acuerdo entre el Ministerio de Salud, la Caja Costarricense de Seguro Social y la Asociación Costarricense de Pediatría...
Determinants of Adequate Control in Diabetic Patients; Application of Multilevel Analysis for Costa Rica
Authors: Aparicio Amada , Morera Salas Melvin 
Published: March 2021

Aim: To establish an initial approach to identify individual and group variables that determine adequate interventions on diabetic patients by the Basic Integral Healthcare Units of the Costa Rican social security system. Methods: The study design is non-experimental, cross-sectional and applies multi-level logistic regression. The data were obtained from a sample chosen from the Health Services Purchasing Direction, and includes diabetic patients cared for at local levels from January to December 2004. The information was used at 2 levels of analysis: level 1 (individual) and level 2 (group), and glycosylated hemoglobin was used as a dependent variable. Results: Forty-nine percent of patients were controlled, with a median age above 60 years, 66% were women, and 76,6% had a body mass index reflecting overweight or obesity. On average, the Basic Integral Healthcare Units in the study had 7 years since initiating the reform process, and their average score on the “Commitment of Management” for the last 5 years was 87%. Moreover, the average population covered was 40 thousand inhabitants, and 22% of them had high school education. Multilevel logistic regression revealed that as diabetic patients age the probability of achieving control of the disease also increases. Women had a lower probability of being under control as compared to men. Diabetic patients belonging to the Basic Integral Healthcare Units that initiated their reform earlier, and those belonging to health services achieving higher scores on the “Commitment of Management” had a higher probability of being under control, even though this finding was not statistically significant, with respect to the other variables in the model. Discussion: Approximately between 6% and 10% of the variance in the control of diabetic patients is explained by differences within local health services, after controlling for other intervening variables
Sal mediterránea, yogur, genética e inmunoterapia
Authors: Madrigal Oscar Porras 
Published: March 2021

La historia de una herramienta molecular que ha llegado a ser utilizada en el tratamiento de leucemias y linfomas, nos envía en la máquina del tiempo, 25 años atrás, a la Costa Blanca de España para devolvernos en 2018 a la realidad de una nueva opción para el tratamiento de las malignidades hematológicas. La historia nació en 1993 con el investigador español Francisco Mojica, quien entonces estudiaba los efectos de la salinidad sobre las enzimas de restricción que cortaban el genoma de Haloferax mediterranei. Mojica encontró algo no descrito: copias múltiples de secuencias paliondrómicas de bases nitrogenadas en el ADN de H. mediterranei, y en otros organismos que estudió siguiendo la línea de investigación de su hallazgo, nombrado “Clustered Regularly Interspaced Paliondromic Repeats” (CRISPR). La explosión de conocimiento sobre CRISPR permitió que en pocos años aumentara en forma exponencial el número de microorganismos en lo que se demostró la presencia del descubrimiento y se generó un sistema de clasificación en 2 clases y 5 tipos, lo mismo que la identificación de genes adyacentes con funciones relacionadas. Sin embargo, hasta 2002 era un descubrimiento interesante, una curiosidad apasionante, prometedora, generadora de investigación, pero sin una aplicación definida.
Comparative Pharmacognostical Evaluation of Five Different Market Samples of Piper Longum Linn.
Authors: Gopani Tejal , Vidhi Bapna , Patel Mariyan 
Published: March 2021

Pippalimoola (root of Piper longum.linn) is one of most important drug in Ayurveda used as single drug and in combination with other herbs ,minerals or metallic preparations for poly herbo-mineral formulations.. In Ancient literature we found that in the name of ‘Moola’(means firmly fixed a root) we must practice root but now a days instead of Pippali moola most of market samples are substituted with stem of same plant, so it is essential to check the botanical source of market samples.In this study,different five market samples of Pippalimoola were procured all over India and one sample (control) was collected after authentication of botanical source of plant.Pharmacognostical study was undertaken to observe morphological characters of market samples and compared with the collected sample. It was observed that out of five market samples; macroscopic and microscopic characters of one sample was matched with the characters of control root sample. While other four samples were found to be stem of the plant. Hence there is lots of variation in raw material of the plant in Indian market.
Evaluation of effect of efficacy of Koshtha Shuddhi in the Management of Gridrasi (Sciatica)
Authors: Maragalawaththa Sandeepanie , Ediriweera E.R.H.S.S. 
Published: March 2021

Introduction: Sciatica is a medical condition of pain going down the leg through back, outside, or front of the leg from the lower back. It can be co-related with Grdrasi caused by both the aggravated Vata and Kapha two elements out of three basic elements of the body. Diagnostic method of disease is different and management also based on root cause of the disease. Sepalika (Nyctanthes arbor-tristis.Linn.)(Oleacea) leaves are having anti inflammatory effect and analgesic effect. Aim and Objectives: To Evaluate the efficacy of Koshtha (GIT) (Gastro Intestinal tract) Shuddhi (Purification) in the management of Gridrasi w.s.r. to Sciatica. Material and methods: For this study, 20 patients were resisted and divided into two groups. Registered patients of group A and Group B were given Koshtha Shuddhi with Sepalika leaves decoction along with Sashapadi oil Abhyanga and Sand Potali fomentation and Sepalika leaves decoction along with Sashapadi oil Abhyanga and Sand Potali fomentation respectively for 2 weeks before meal. Patients of group A were given 120ml of Vasagudushi decoction with 5ml Eranada oil twice a day for purpose of Koshtha Shuddhi for 3 days. The effect of therapy was evaluated on the basis of changes of chief complaints and SLR test was taken for assessment parameter. Discussion: The statistically significant relief was showed on the chief complaints of Gridrasi (Sciatica) in the both the groups except Ruk (Pain) in group B. SLR of all the patient of present study were in between 30o- 70o in R/side LL (Lower Limb). SLR was changed of both the groups up to 70o-90o and 100% showed relief except 4 patients in the group B. Conclusion: It can be concluded that the Koshtha Shuddhi is showed comparatively better effect than management of Gridrasi (Sciatica) without carried out Koshtha Shuddhi.