bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer patient management: role of multidisciplinary teams
Authors: Luu Tuan Trong 
Published: December 2021

ObjectivesAs a cancer model recommended by numerous governments and health care systems, multidisciplinary teams (MDTs) can improve clinical decision-making and overall patient care quality. This paper aims to discuss key elements and resources, as well as contingencies for effectiveness MDTs and their meetings.MethodsWe derived elements, resources, and contingencies for effective MDTs by analyzing articles on the themes of MDTs and MDT meetings.ResultsThis paper identifies key elements comprising MDT characteristics, team governance, infrastructure for MDM, MDM organization, MDM logistics, and clinical decision-making in light of patient-centeredness. Resources that facilitate an MDM functioning consist of human resources and non-human resources. The paper further detects barriers to the sustainable performance of MDTs and provide suggestions for improving their functioning in light of patients’ and healthcare providers’ perspectives.ConclusionsMDTs are vital to cancer care through enabling healthcare professionals with diversity of clinical specialties to collaborate and formulate optimal treatment recommendations for patients with suspected or confirmed cancer.
Ribosomal protein S6 kinase beta-1 gene variants cause hypertrophic cardiomyopathy
Authors: Jain Pratul Kumar , Jayappa Shashank , Sairam Thiagarajan , Mittal Anupam , Paul Sayan , Rao Vinay J , Chittora Harshil , Kashyap Deepak K , Palakodeti Dasaradhi , Thangaraj Kumarasamy , Shenthar Jayaprakash , Koranchery Rakesh , Rajendran Ranjith , Alireza Haghighi , Mohanan Kurukkanparampil Sreedharan , Rathinavel Andiappan , Dhandapany Perundurai S 
Published: December 2021

BackgroundHypertrophic cardiomyopathy (HCM) is a genetic heart muscle disease with preserved or increased ejection fraction in the absence of secondary causes. Mutations in the sarcomeric protein-encoding genes predominantly cause HCM. However, relatively little is known about the genetic impact of signalling proteins on HCM.Methods and resultsHere, using exome and targeted sequencing methods, we analysed two independent cohorts comprising 401 Indian patients with HCM and 3521 Indian controls. We identified novel variants in ribosomal protein S6 kinase beta-1 (RPS6KB1 or S6K1) gene in two unrelated Indian families as a potential candidate gene for HCM. The two unrelated HCM families had the same heterozygous missense S6K1 variant (p.G47W). In a replication association study, we identified two S6K1 heterozygotes variants (p.Q49K and p.Y62H) in the UK Biobank cardiomyopathy cohort (n=190) compared with matched controls (n=16 479). These variants are neither detected in region-specific controls nor in the human population genome data. Additionally, we observed an S6K1 variant (p.P445S) in an Arab patient with HCM. Functional consequences were evaluated using representative S6K1 mutated proteins compared with wild type in cellular models. The mutated proteins activated the S6K1 and hyperphosphorylated the rpS6 and ERK1/2 signalling cascades, suggesting a gain-of-function effect.ConclusionsOur study demonstrates for the first time that the variants in the S6K1 gene are associated with HCM, and early detection of the S6K1 variant carriers can help to identify family members at risk and subsequent preventive measures. Further screening in patients with HCM with different ethnic populations will establish the specificity and frequency of S6K1 gene variants.
Carotid artery direct access for mechanical thrombectomy: the Carotid Artery Puncture Evaluation (CARE) study
Authors: Dumas Victor , Kaesmacher Johannes , Ognard Julien , Forestier Géraud , Dargazanli Cyril , Janot Kevin , Behme Daniel , Shotar Eimad , Chabert Emmanuel , Velasco Stéphane , Bricout Nicolas , Ben Hassen Wagih , Veunac Louis , Geismar Maxime , Eugene Francois , Detraz Lili , Darcourt Jean , L'Allinec Vincent , Eker Omer F , Consoli Arturo , Maus Volker , Gariel Florent , Marnat Gaultier , Papanagiotou Panagiotis , Papagiannaki Chrisanthi , Escalard Simon , Meyer Lukas , Lobsien Donald , Abdullayev Nuran , Chalumeau Vanessa , Neau Jean Philippe , Guillevin Rémy , Boulouis Gregoire , Rouchaud Aymeric , Styczen Hanna , Fauché Cédric 
Published: December 2021

BackgroundIn acute ischemic stroke due to anterior large vessel occlusion (AIS-LVO), accessing the target occluded vessel for mechanical thrombectomy (MT) is sometimes impossible through the femoral approach. We aimed to evaluate the safety and efficacy of direct carotid artery puncture (DCP) for MT in patients with failed alternative vascular access.MethodsWe retrospectively analyzed data from 45 stroke centers in France, Switzerland and Germany through two research networks from January 2015 to July 2019. We collected physician-centered data on DCP practices and baseline characteristics, procedural variables and clinical outcome after DCP. Uni- and multivariable models were conducted to assess risk factors for complications.ResultsFrom January 2015 to July 2019, 28 149 MT were performed, of which 108 (0.39%) resulted in DCP due to unsuccessful vascular access. After DCP, 77 patients (71.3%) had successful reperfusion (modified Thrombolysis In Cerebral Infarction (mTICI) score ≥2b) and 28 (25.9%) were independent (modified Rankin Scale (mRS) score 0–2) at 3 months. 20 complications (18.5%) attributed to DCP occurred, all of them during or within 1 hour of the procedure. Complications led to extension of the intubation time in the intensive care unit in 7 patients (6.4%) and resulted in death in 3 (2.8%). The absence of use of a hemostatic closure device was associated with a higher complication risk (OR 3.04, 95% CI 1.03 to 8.97; p=0043).ConclusionIn this large multicentric study, DCP was scantly performed for vascular access to perform MT (0.39%) in patients with AIS-LVO and had a high rate of complications (18.5%). Our results provide arguments for not closing the cervical access by manual compression after MT.
A solvable contact potential based on a nuclear model
Authors: Martín-Mozo A. , Nieto L. M. , Romaniega C. 
Published: December 2021

AbstractWe extend previous works on the study of a particle subject to a three-dimensional spherical singular potential including a $$\delta $$
δ
–$$\delta '$$

δ
′

contact interaction. In this case, to have a more realistic model, we add a Coulombic term to a finite well and a radial $$\delta $$
δ
–$$\delta '$$

δ
′

contact interaction just at the edge of the well, which is where the surface of the nucleus would be. We first prove that the we are able to define the contact potential by matching conditions for the radial function, fixing a self-adjoint extension of the non-singular Hamiltonian. With these matching conditions, we are able to find analytic solutions of the wave function and focus the analysis on the bound state structure characterizing and computing the number of bound states. For this approximation for a mean-field Woods–Saxon model, the Coulombic term enables us to complete the previous study for neutrons analyzing the proton energy levels in some doubly magic nuclei. In particular, we find the appropriate $$\delta '$$

δ
′

contribution fitting the available data for the neutron- and proton-level schemes of the nuclei $${}^{{208}}$$

208

Pb, $${}^{{40}}$$

40

Ca, and $${}^{{16}}$$

16

O.
Synthesis and Characterization of NiFe2O4Magnetic Nanoparticles for Magnetic Resonance Imaging Application
Authors: Sitthichai Sudarat , Junploy Patcharanan , Thongtem Titipun , Pilapong Chalermchai , Phuruangrat Anukorn , Thongtem Somchai 
Published: December 2021

NiFe2O4magnetic nanoparticles (MNPs) were synthesized by co-precipitation of iron (III) chloride hexahydrate and nickel (II) chloride hexahydrate in the solution containing 45% hydrazine at 80∘C. Phase, morphology, oxidation state and magnetic properties were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), selected area electron diffraction (SAED), X-ray photoelectron spectroscopy (XPS) and vibrating sample magnetometry (VSM). In this research, pure NiFe2O4MNPs synthesized in the solution with the pH of 10 with saturation magnetization of 49.839[Formula: see text]emu/g were detected and were able to be used for magnetic resonance imaging (MRI) application with very high contrast.Highlights: [Formula: see text] NiFe2O4is used as magnetic nanoparticles. [Formula: see text] They have an excellent saturation magnetization. [Formula: see text] The promising material is used for magnetic resonance imaging application.
An In Vivo CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression
Authors: Scheidmann Manuel C. , Castro-Giner Francesc , Strittmatter Karin , Krol Ilona , Paasinen-Sohns Aino , Scherrer Ramona , Donato Cinzia , Gkountela Sofia , Szczerba Barbara M. , Diamantopoulou Zoi , Muenst Simone , Vlajnic Tatjana , Kunz Leo , Vetter Marcus , Rochlitz Christoph , Taylor Verdon , Giachino Claudio , Schroeder Timm , Platt Randall J. , Aceto Nicola 
Published: December 2021

Abstract

Blood-borne metastasis of breast cancer involves a series of tightly regulated sequential steps, including the growth of a primary tumor lesion, intravasation of circulating tumor cells (CTC), and adaptation in various distant metastatic sites. The genes orchestrating each of these steps are poorly understood in physiologically relevant contexts, owing to the rarity of experimental models that faithfully recapitulate the biology, growth kinetics, and tropism of human breast cancer. Here, we conducted an in vivo loss-of-function CRISPR screen in newly derived CTC xenografts, unique in their ability to spontaneously mirror the human disease, and identified specific genetic dependencies for each step of the metastatic process. Validation experiments revealed sensitivities to inhibitors that are already available, such as PLK1 inhibitors, to prevent CTC intravasation. Together, these findings present a new tool to reclassify driver genes involved in the spread of human cancer, providing insights into the biology of metastasis and paving the way to test targeted treatment approaches.

Significance:
A loss-of-function CRISPR screen in human CTC-derived xenografts identifies genes critical for individual steps of the metastatic cascade, suggesting novel drivers and treatment opportunities for metastatic breast cancers.
Convolution-Based Model-Solving Method for Three-Dimensional, Unsteady, Partial Differential Equations
Authors: Zha Wenshu , Zhang Wen , Li Daolun , Xing Yan , He Lei , Tan Jieqing 
Published: December 2021

AbstractNeural networks are increasingly used widely in the solution of partial differential equations (PDEs). This letter proposes 3D-PDE-Net to solve the three-dimensional PDE. We give a mathematical derivation of a three-dimensional convolution kernel that can approximate any order differential operator within the range of expressing ability and then conduct 3D-PDE-Net based on this theory. An optimum network is obtained by minimizing the normalized mean square error (NMSE) of training data, and L-BFGS is the optimized algorithm of second-order precision. Numerical experimental results show that 3D-PDE-Net can achieve the solution with good accuracy using few training samples, and it is of highly significant in solving linear and nonlinear unsteady PDEs.
Bridging the Gap Between Neurons and Cognition Through Assemblies of Neurons
Authors: Papadimitriou Christos H. , Friederici Angela D. 
Published: December 2021

Abstract
During recent decades, our understanding of the brain has advanced dramatically at both the cellular and molecular levels and at the cognitive neurofunctional level; however, a huge gap remains between the microlevel of physiology and the macrolevel of cognition. We propose that computational models based on assemblies of neurons can serve as a blueprint for bridging these two scales. We discuss recently developed computational models of assemblies that have been demonstrated to mediate higher cognitive functions such as the processing of simple sentences, to be realistically realizable by neural activity, and to possess general computational power.
Validation of the Modified Rhinoplasty Assessment Scale (Photographic)
Authors: Bayrak Sinehan B. , Penn Joseph , Hu Jinxiang , David Kriet John , Humphrey Clinton D. 
Published: December 2021

Objective: To validate the modified Rhinoplasty Assessment Scale (Photographic) (mRASP). Study Design: Retrospective cohort study. Methods: Study design—Photographs for 100 rhinoplasty patients from 2 facial plastic surgeons were compiled. Photos included 6 views. Each facial plastic surgeon reviewed all views. Nasal appearance was evaluated using the mRASP. Statistical analysis—A validation study was conducted, including descriptive statistics, reliability, and construct validity. Mean and standard deviations were used to describe the scores. Results: Eighty female (mean RASP score = 14.89, SD = 7.04) and 20 male (mean RASP score = 19.83, SD = 10.09) patients were included. The mean of the total score on the instrument was 15.88 (SD = 7.98). Cronbach’s alpha was .81, and inter-rater reliability measured as a Pearson product-moment correlation was .74. The CFA model fit the frontal view (χ2 = 32.47 ( P = .04), CFI = .99, TLI = .99, RMSEA = .05, SRMR = .05), basal view (χ2 = 4.55 ( P = .33), CFI = .98, TLI = .96, RMSEA = .03, SRMR = .23), and lateral view (χ2 = 39.52 ( P = .40), CFI = 1.0, TLI = 1.0, RMSEA = .0, SRMR = .05) data well. Conclusion: The mRASP is a reliable instrument that can be used to assess nasal form via frontal, lateral, and basal photographs of patients. This provides facial plastic surgeons with a validated tool to evaluate rhinoplasty outcomes.
Bioabsorbable dressing impregnated with betamethasone and ciprofloxacin after endoscopic sinus surgery: A randomized, double-blind, placebo-controlled study
Authors: Wierzchowska Małgorzata , Kalińczak-Górna Paulina , Grześkowiak Błażej , Radajewski Kamil , Burduk Jakub , Burduk Paweł 
Published: December 2021

Background In addition to its hemostatic and stabilization role, biodegradable nasal packing can be used as a carrier for drugs after functional endoscopic sinus surgery (FESS). The aim of this study was to compare the influence of biodegradable synthetic polyurethane foam (NasoPore) soaked with ciprofloxacin, or betamethasone, or both to the same foam soaked with saline after FESS. Methods 120 adults with chronic rhinosinusitis, with and without polyps, directed for bilateral full-house FESS were enrolled for the study. The patients were randomized and blinded into 3 groups, depending on the type of postoperative procedure applied. Thus, NasoPore soaked with antibiotic was provided to the first group; in the second group, the steroid was used; and the combination of both, in the third group. In each case, the aforementioned procedure was administered on one side of the nose, while NasoPore was soaked in saline on the other, at the end of the surgery, respectively. The patients were requested to complete a questionnaire during their postoperative visits at 2, 10, 30, 90, and 180 days, scoring the level of complaints on the VAS scale, separately for each side. The evaluation of the healing process was performed at each visit using rigid endoscopy and subsequently rated on numerical scales. Results Decreased mucosal edema and secretion; reduced Lund-Kennedy score; and favorable influences on facial pressure, nasal blockage, and smell were most evidently seen in the group receiving the antibioticsteroid combination. Conclusions The application of biodegradable nasal packing with betamethasone and ciprofloxacin in sino-nasal surgery has positive effects not only on the healing process but also impacts patient’s comfort. To optimize it, however, further research is needed.
Sensory Deprivation and Psychiatric Disorders: Association, Assessment and Management Strategies
Authors: Sahoo Swapnajeet , Naskar Chandrima , Singh Ajaypal , Rijal Rika , Mehra Aseem , Grover Sandeep 
Published: December 2021

Background: Sensory deprivation (SD) is a widely prevalent condition that leads to various health-related consequences and is also an important cause of disability worldwide. Earlier, SD experiments were used as research modalities to alter human behavior. In recent years, the focus has shifted to understand how SD can affect the mental health of individuals (with congenital or acquired sensory impairments). This narrative review focuses on the current understanding about the association of SD and psychiatric disorders. Methods: A comprehensive literature search was done PubMed, Scopus, PsycINFO, and Google Scholar and in the cross-references of relevant articles. Keywords included “sensory deprivation,” “blindness,” “deafness,” “mental illness,” “psychiatric disorders,” “prevalence,” “assessment,” and “management” in various combinations. Only original articles (abstract and full text) published in English till October 2020 were included. Results: The prevalence of anxiety, depression, dementia, suicidality, and psychosis in persons with SD is higher than the general population (highest being in persons with dementia with comorbid SD). Several mechanisms/hypotheses have been proposed to explain these associations. Assessment of SD includes a thorough history taking, with adequate awareness about the difficulties faced during a psychiatric interview in this population. Modifications in the psychometric assessment procedures are warranted. Management depends on a multi-disciplinary approach that includes proper referral to specialties, pharmacological management (depending on diagnosis as well as taking care of ototoxic/ocular side-effect profile of the drugs), and nonpharmacological supportive measures. Conclusions: SD is a complex condition, and evidence suggests that persons with SD have higher psychiatric morbidity. A comprehensive assessment, along with holistic management approach is warranted.
Contributions of Reality TV Consumption to College Women’s Endorsement of the Heterosexual Script and Acceptance of Sexualized Aggression
Authors: Papp Leanna J. , Ward L. Monique , Marshall Riley A. 
Published: December 2021

A prominent feature of mainstream television, especially reality programming, is a heterosexual script that outlines women’s and men’s traditional courtship roles. Although frequent media use is believed to produce greater acceptance of this script, existing analyses have not fully delineated contributions of scripted versus reality programming or tested these notions using a holistic heterosexual script scale. We addressed these limitations in two studies. In Study 1, 466 undergraduate women indicated their support of the heterosexual script and their consumption of popular reality programs, sitcoms, and dramas. Heavier viewing of reality programming predicted greater support for the heterosexual script, and heavier viewing of sitcoms predicted weaker support. In Study 2, we used longitudinal data to explore relations between viewing reality television, acceptance of the heterosexual script, and acceptance of sexualized aggression during undergraduate women’s first 2 years in college ( N = 244). We found that reality television consumption was not a direct predictor of acceptance of sexualized aggression but was a significant, indirect predictor through endorsement of the heterosexual script. These studies contribute to our understanding of unique media contributions to endorsement of the heterosexual script and illuminate one process by which women may come to normalize sexual mistreatment. Campus educational programming on sexuality, sexual assault, and healthy relationships may be able to intervene in this normalization through critique of the heterosexual script and media portrayals of dating and relationships. Online slides for instructors who want to use this article for teaching are available on PWQ's website at http://journals.sagepub.com/doi/suppl/10.1177/03616843211044686
Exploring the Perceptions of Nurses on Receiving the SARS CoV-2 Vaccine in Palestine: A Qualitative Study
Authors: Belkebir Souad , Maraqa Beesan , Nazzal Zaher , Abdullah Abdullah , Yasin Ferial , Al-Shakhrah Kamal , Zink Therese 
Published: December 2021

Background Uncertainty about vaccination among nurses are major barriers to managing the ongoing COVID-19 pandemic worldwide. Purpose To explore nurseś perceptions about receiving the SARS CoV-2 vaccine to inform the upcoming Palestinian Ministry of Health (MOH) vaccination efforts. Methods Four focus groups were conducted with nurses between January 18 and 30, 2021, before MOH launched vaccinations in Palestine. Participants working in government and private facilities were invited to participate and completed an online or paper form to provide demographics, review the study purpose, and give consent. Meetings were facilitated in Arabic either online via the Zoom platform or face-to-face using the same interview guide. Transcripts were translated into English and coded using a template analysis approach. Results Forty-six nurses, with a median age of 29.5y (range, 22–57) from across Palestine participated. Three major themes emerged: uncertainty, trust, and the knowledge needed to move forward. Uncertainty related to the evolving nature of COVID-19, the rapidity of vaccine development, the types and timing of available vaccines. The need for trusted experts to share scientific information about the vaccines to counteract the misinformation in social media. Moreover, reliable vaccine information may help vaccine-hesitant nurses move to vaccine-acceptors and to convince others, including their patients. Conclusion The negative perception of nurses towards vaccines is problematic in Palestine and uncertainty about which vaccine(s) will be available adds to the lack of education and mass-media misinformation. Other countries with vaccination efforts that are not wholly planned or implemented and may be struggling with similar concerns.
Is Cytoreductive Surgery Possible in Cervical Cancer Peritoneal Carcinomatosis?
Authors: Duzgun Ozgul , Kalin Murat 
Published: December 2021

Background: The number of cases of cervical cancer with recurrence and peritoneal carcinomatosis is limited. In our study, we aimed to present the results of cytoreductive surgery hyperthermic intraperitoneal chemotherapy treatment and its 3-year early period results in patients with peritoneal metastases due to cervical cancer. Methods: Data of 306 patients who had undergone cytoreductive surgery hyperthermic intraperitoneal chemotherapy between May 2016 and 2021 because of intra-abdominal metastases were collected prospectively and evaluated retrospectively. Ten cases who had undergone cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy due to cervical peritoneal carcinomatosis were included in this study. Results: Average time of operation was 5 (range = 3-6) hours, mean average of peritoneal carcinomatosis index score was 12.3 (range = 7-36), and mean average of completeness of cytoreduction score was 1 in 2 patients and 0 in 8 patients. No mortality was recorded in 30 days postoperatively. Four patients relapsed and died because of pneumonia, coronavirus disease, pulmonary embolism, and terminal illness. These patients died at 2, 5, 6, and 12 months, respectively. Six patients are still alive and early period tumor relapse has not been reported during their follow-ups. Conclusions: This study has a limited number of patients and the results are early period results. The follow-up of patients were not long term. Therefore, it is hard to say that cytoreductive surgery hyperthermic intraperitoneal chemotherapy could be of any benefit looking at the results. Long-term results should be waited. Also, multicentered randomized cohort study with large sample size is required to evaluate this invasive procedure.