bluuebunny/crossref_metadata_2025_split huggingface dataset:
I’am hiQ – A Novel Accuracy Index for Imputed Genotypes
Authors: Rosenberger Albert , Tozzi Viola , Hung Rayjean J , Christiani David C , Caporaso Neil E , Liu Geoffrey , Bojesen Stig E , Marchand Loic Le , Albanes Demetrios , Aldrich Melinda C , Tardon Adonina , Fernández-Tardón Guillermo , Rennert Gad , Field John K , Davies Mike , Liloglou Triantafillos , Kiemeney Lambertus A , Lazarus Philip , Haugen Aage , Zienolddiny Shanbeh , Lam Stephen , Schabath Matthew B , Andrew Angeline S , Duell Eric J , Arnold Susanne M , Brunnsstöm Hans , Melander Olle , Goodman Gary E , Chen Chu , Doherty Jennifer A , Teare Marion Dawn , Cox Angela , Woll Penella J , Risch Angela , Muley Thomas R , Johansson Mikael , Brennan Paul , Landi Maria Teresa , Shete Sanjay S , Amos Christopher I , Bickeböller Heike 
Published: February 2021

Abstract
Background: Imputation of untyped markers is a standard tool in genome-wide association studies to close the gap between directly genotyped and other known DNA variants. However, high accuracy with which genotypes are imputed is fundamental. Several accuracy measures have been proposed and some are implemented in imputation software, unfortunately diversely across platforms. In the present paper we introduce I’am hiQ, an independent pair of accuracy measures that can be applied to dosage files, the output of all imputation software. I’am (imputation accuracy measure) quantifies the average amount of individual-specific versus population-specific genotype information in a linear manner. hiQ (heterogeneity in quantities of dosages) addresses the inter-individual heterogeneity between dosages of a marker across the sample at hand. Results: Applying both measures to a large case-control sample of the International Lung Cancer Consortium (ILCCO), comprising 27,065 individuals, we found meaningful thresholds for I’am and hiQ suitable to classify markers of poor accuracy. We demonstrate how Manhattan-like plots and moving averages of I’am and hiQ can be useful to identify regions enriched with less accurate imputed markers, whereas these regions would by missed when applying the accuracy measure info (implemented in IMPUTE2). Conclusion: We recommend using I’am hiQ additional to other accuracy scores for variant filtering before stepping into the analysis of imputed GWAS data.
Photoinduced Electron Transfer Reactions of Water Soluble Porphyrins in Zeolite Environment
Authors: Venkattappan Anbazhagan , Velappan Kandavelu , Rajalingam Renganathan 
Published: February 2021

Abstract
Excited state interactions of zeolite adsorbed porphyrins have been investigated by steady state luminescence quenching technique with certain antioxidants such as reduced glutathione, ascorbic acid and L-cysteine. The zeolite supported porphyrins, meso-tetra (N-methyl-4-pyridyl) porphyrin (H2TMPyP4+) and zinc tetra(N-methyl-4-pyridyl) porphyrin (ZnTMPyP4+) was prepared and characterized by various techniques such as Diffuse Reflectance Spectra (DRS), Scanning Electron Microscope (SEM), powder X-Ray Diffraction (XRD) and BET surface area. The interaction of zeolites with porphyrins are shown to increase the lifetime of the singlet excited state of porphyrins and decays are biphasic in nature. The splitting of the emission band of porphyrins occurs in 1:1 glycerol: water solution due to the changes in the dielectric of the solvation sphere associated with porphyrin. The Stern-Volmer plots of I0/I vs quencher total concentration [Q] were linear in the whole range of [Q] used. This study revealed effective quenching for zinc porphyrin compared to free base porphyrin. The effect of quenchers and zeolite acidity has also been studied. Quenching rate constant (kq) is on the order of 109 M−1 s−1. The quenching reaction obeys Rehm-Weller Equation and is shown to be due to thermodynamically favoured electron transfer from quenchers to the excited singlet state of porphyrins (reductive quenching).
Sequential Treatment of Afatinib and Osimertinib in Patients with Advanced Non-small Cell Lung Cancer Harboring EGFR Mutations: Results from a Real-world Study in South Korea
Authors: Kim Taeyun , Jang Tae Won , Choi Chang Min , Kim Mi-Hyun , Lee Sung Yong , Park Cheol-Kyu , Chang Yoon Soo , Lee Kye Young , Kim Seung Joon , Yang Sei Hoon , Ryu Jeong Seon , Lee Jeong Eun , Lee Shin Yup , Park Chan Kwon , Lee Sang Hoon , Jang Seung Hun , Yoon Seong Hoon 
Published: February 2021

Abstract
The optimal sequence for administration of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) for treating non-small cell lung cancer (NSCLC) is still unclear. This study aimed to evaluate the efficacy of sequential afatinib and osimertinib treatment in patients with NSCLC harboring EGFR mutations. Electronic records of patients with EGFR-mutated NSCLC, who were administered afatinib and osimertinib (group A) or other chemotherapy (group B) between October 2014 and October 2019, across 16 hospitals in South Korea were reviewed. The primary outcome, time on treatment (TOT), secondary outcome, and overall survival (OS) were estimated using the Kaplan-Meier method and log-rank test. Multivariate analyses were performed using the Cox proportional hazards model. Of the 737 patients who received frontline afatinib treatment, 360 with complete records were selected (group A:154, group B: 206). The median TOT was 33.9 months (95% confidence interval [CI]: 24.5−43.3) in group A and 21.3 months (95% CI: 19.4−23.1) in group B. The median TOT with afatinib was 12.9 months (95% CI: 11.8−14.0) overall, and 15.2 months (95% CI: 13.2−17.1) in group A. The 2- and 3-year survival rates were 86.0% and 69.3% in group A and 75.9% and 55.3% in group B, respectively. Sequential afatinib and osimertinib treatment resulted in better survival rates than treatment with afatinib followed by other chemotherapies. Therefore, this sequential treatment strategy may offer clinical benefits to patients with EGFR-mutated NSCLC.
Effect of Productive Capacities on Economic Complexity: Do Aid for Trade flows Matter?
Authors: GNANGNON Sèna Kimm 
Published: February 2021

Abstract
The COVID-19 health pandemic has exposed the strong vulnerabilities of countries, including developing ones to shocks, and underlined the need for exploring ways to strengthen countries' resilience to future shocks. The current paper uses the dataset made recently available by the United Nations Conference on Trade and Development (UNCTAD) to examine (for the first time) the effect of productive capacities on economic complexity. The analysis further investigates whether Aid for Trade (AfT) flows matter for the influence of productive capacities on economic complexity in recipient-countries. The analysis uses a sample of 126 countries (including both developed and developing countries) over the period 2002-2018, and adopts the two-step system Generalized Methods of Moments (GMM) approach. Results have shown that productive capacities exert a positive effect on economic complexity over the full sample. However, the magnitude of this positive effect varies across different sub-samples, with Least developed countries (LDCs) enjoying the lowest magnitude of this positive effect. Furthermore, total AfT flows are positively associated with economic complexity, with LDCs enjoying a higher positive effect than other countries. Interestingly, total AfT flows exert a higher positive effect on economic complexity in countries that experience low levels of overall productive capacities. The latter finding highlights the need for donor-countries to scale-up AfT flows in favour of countries (such as LDCs) that are characterized by low levels of productive capacities. Finally, the empirical outcomes indicate that productive capacities enhance economic complexity in countries that receive higher amounts of total NonAfT flows.
Case study comparing Fiala-based thermophysiological model and PHS Index with experimental data to predict heat strain in normal and protective clothing
Authors: Kopeckova Barbora , Pokorny Jan , Lunerova Kamila , Fiser Jan , Jicha Miroslav 
Published: February 2021

The use of protective clothing under extreme conditions leads to heat stress with undesired consequences on human physiology. As a prevention measure, thermal indices and thermophysiological models have been developed. Based on these models and indices, it is possible to estimate the time limits for staying under risky conditions, e.g., by the predicted rectal temperature whose value is one of the most important parameters used for assessing the heat stress. This article is focused on the comparison of rectal and mean skin temperature prediction realized by the Fiala-based thermophysiological model (FMTK) and Predicted heat strain (PHS) index with results from the real experiment for normal and protective clothing. Three types of ensembles were tested and simulated as follows: Klimatex underwear, air-permeable military NBC suit M2000 (FOP), and impermeable chemical protective clothing Tychem-F. The real experiments of thermal strain were performed with one male participant (80 kg, 1.75 m) walking on the treadmill located in the climate chamber. The temperature range for neutral and hot tests was set from 25 °C to 40 °C. The rectal temperature, skin temperatures, and heart rate were measured. The results showed that PHS index is well usable for normal clothing (Klimatex underwear) and air-permeable protective clothing (FOP) under various ambient temperatures, and it is able to give results similar to FMTK model and experiment, the mean absolute error MAE for rectal temperature prediction was for all ambient temperatures lower than 0.5 °C. FMTK model demonstrated good predictability for impermeable protective clothing Tychem-F, the maximum value of MAE 0.69 °C. Whereas PHS index showed several times larger error, the maximum value higher than 1.8 °C, in the prediction for this type of clothing. The performed simulations showed that the accuracy of the prediction by the PHS index is not so strongly dependent on the value of the overall clothing resistance, but it depends on the value of the moisture permeability index (permeable vs impermeable clothing) which is connected with the water vapor partial pressure under the clothing.
Public Interest in Cosmetic Surgical and Minimally Invasive Plastic Procedures During the COVID-19 Pandemic: Infodemiology Study of Twitter Data
Authors: Liu Wenhui , Wei Zhiru , Cheng Xu , Pang Ran , Zhang Han , Li Guangshuai 
Published: February 2021

BackgroundThe unprecedented COVID-19 pandemic has brought drastic changes to the field of plastic surgery. It is critical for stakeholders in this field to identify the changes in public interest in plastic procedures to be adequately prepared to meet the challenges of the pandemic.ObjectiveThe aim of this study is to examine tweets related to the public interest in plastic procedures during the COVID-19 pandemic and to help stakeholders in the field of plastic surgery adjust their practices and sustain their operations during the current difficult situation of the pandemic.MethodsUsing a web crawler, 73,963 publicly accessible tweets about the most common cosmetic surgical and minimally invasive plastic procedures were collected. The tweets were grouped into three phases, and the tweeting frequencies and Google Trends indices were examined. Tweeting frequency, sentiment, and word frequency analyses were performed with Python modules.ResultsTweeting frequency increased by 24.0% in phase 2 and decreased by 9.1% in phase 3. Tweets about breast augmentation, liposuction, and abdominoplasty (“tummy tuck”) procedures consecutively increased over the three phases of the pandemic. Interest in Botox and chemical peel procedures revived first when the lockdown was lifted. The COVID-19 pandemic was associated with a negative impact on public sentiment about plastic procedures. The word frequency pattern significantly changed after phase 1 and then remained relatively stable.ConclusionsAccording to Twitter data, the public maintained their interest in plastic procedures during the COVID-19 pandemic. Stakeholders should consider refocusing on breast augmentation, liposuction, and abdominoplasty procedures during the current phase of the pandemic. In the case of a second wave of COVID-19, stakeholders should prepare for a temporary surge of Botox and chemical peel procedures.
Leadership core competencies for higher education facilities managers
Authors: Goodermote Christina 
Published: February 2021

ABSTRACT
The higher education facilities manager has a broad spectrum of leadership responsibilities for maintaining the institutional campus, which includes the management of buildings and grounds maintenance as well as people and customer service management. Leadership core competencies for the higher education facilities manager can be just as varied as the job duties. Therefore, a literature review was conducted to determine the leadership core competencies for higher education facilities managers. A data analysis using a two-stage qualitative thematic coding of the available literature contributed to the development of eight leadership master core competencies, which are: Physical Asset Operational Knowledge, Organizational Effectiveness, Strategy/Vision Leadership, Human Resources Administration, Relationship Cultivation, Communicative Expertise, Governance Acumen and Decision Making/Conflict Resolution. Higher education facilities entities can utilize the set of eight competencies as parameters for hiring managers into the profession, for employee evaluation and development initiatives and for internal leadership succession planning.
A Survey of O&M Practices for High Performance Buildings in the Building Industry
Authors: Mukhopadhyay Jaya , Kalonde Gilbert , PE Loras O'Toole 
Published: February 2021

ABSTRACT

Purpose —
The purpose of this paper is to document in part the study that was conducted for a research project ASHRAE RP-1650, which investigates the training requirements for sustainable high-performance building (HPB) operations and maintenance (O&M). This paper documents the intent, procedures and findings of a portion of the research project, which includes a survey of O&M practices for high performance buildings in the industry. The purpose of the survey as reported in this paper was to confirm and refine the level of understanding of KSCs for operating HPBs as perceived by O&M personnel in the industry. The details of the survey and the results are presented in this paper. The survey was sent out to facility managers in the industry who are involved with the O&M of HPB systems and equipment. 221 facility managers were surveyed in this study.

Design/methodology/approach —
This study utilizes a concurrent mixed-method research, which considers both qualitative and quantitative responses.

Findings —
The study found that while most technicians were ‘moderately well' to ‘very well' trained for the configuration and components as well as the installation, repair and replacement of different high performance equipment and systems, they lacked essential knowledge to address issues such as: controls; tracking of variables; programming and operation of modulation devices implemented in high-performance systems and equipment. This finding implied a lack of ‘Systems Thinking' approach, which the study found to be pertinent and essential for the O&M of HPB systems and equipment.

Originality/value —
The study is utilized to identify gaps between the training requirements for O&M of HPBs identified from the literature review of the research project and the current industry practices. The identified gaps are valuable to develop learning objectives for training programs that are aimed to train personnel responsible for the O&M of HPBs.
PENDEKATAN ANTROPOLOGI DALAM STUDI ISLAM
Authors: Potabuga Yodi Fitradi 
Published: February 2021

Artikel ini membahas tentang pendekatan antropologi dalam studi islam untuk mengkaji hubungan agama dengan pranata sosial masyarakat. Dasar dari penulisan ini adalah menjelaskan peran pendekatan antropologi dalam mengkaji dan menganalisis fenomena gejala perilaku manusia dalam masyarakat agama islam. Artikel ini merupakan tulisan yang berbasis literatur dengan menghimpun informasi yang dinilai relevan dengan topik dan masalah yag menjadi objek kajian. Hasil dari analisis menjelaskan bahwa melalui pendekatan antropologi dapat diketahui aspek berupa doktrin-doktrin dan fenomenaa-fenomena keagamaan yang tidak terlepas dari jaringan institusi atau kelembagaan sosial kemasyarakatan yang mendukung keberadaan sebuah praktik kebudayaan maupun budaya keagamaan.
INFLUENCE KNOWLEDGE LEVEL FUNDAMENTAL ANALYSIS AND TECHNICAL ANALYSIS ON CONTINUITY OF INVESTING IN SHARIA STOCKS IN SHARIA INVESTMENT GALLERY INDONESIA STOCK EXCHANGE STATE INSTITUTE OF ISLAMIC RELIGION KERINCI
Authors: Suar Abi Suar Alizar , Meirison Meirison Meirison 
Published: February 2021

Once the prospection of sharia trading in the capital market must be supported with a level of knowledge in analyzing the stocks that will be traded. Therefore there is an in-depth knowledge of the analysis of sharia stocks before making transactions on the sharia capital market and needed a deepening of understanding on fundamental and technical analysis to achieve optimal profit in the purchase or sale of Sharia stocks. This research aims to determine the influence of the knowledge level of fundamental analysis in the Continuity of investing in sharia stocks. Influence the level of technical analysis in the continuation of Continuity to invest in sharia stocks and the effect of the knowledge level of fundamental and technical analysis simultaneously on the Continuity of investing in sharia stocks. The research method used in this research is to use a quantitative approach. The result of the study was on a partial (independent) fundamental analysis level (X1) test for the variable Continuity of investing (Y). The influence of Knowledge level technical analysis (X2) partially against the Continuity of investing (Y), both get the result of a tcount < Ttable, OR a significant > 0.05. Zero hypotheses (H0) received, and an alternate hypothesis (HA) is rejected, which means variable X does Not affect the variable Y. Similar results are also obtained From simultaneous calculations (together).
Laparoscopic management of ovarian parasitic myoma: a case report
Authors: Gölbaş Ceren , Gölbaş Hakan , Bayraktar Burak , Biler Alper 
Published: February 2021

Background:
Ovarian leiomyoma is very rare and constitutes 0.5%-1% of ovarian benign masses. Although most adnexal masses are benign, primary purpose of the assessment is to eliminate any malignancies. The most important issue in the evaluation of ovarian masses is to differentiate between malignant and benign masses. Laparoscopy is an important diagnostic and minimally invasive method for these purposes.

Case Presentation:
In this paper, we present a case report on laparoscopic evaluation of a patient who was diagnosed with right ovarian spontaneous parasitic myoma and who did not have a history of uterine surgery.

Conclusion:
Uterine ovarian myoma is extremely rare and can be confused with malignant ovarian masses. Laparoscopy option should be considered as the primary approach in the management of masses with suspicious location and appearance and in the differentiation of benign and malignant.
Shale gas leakage in lower Ecca shales during contact metamorphism by dolerite sill intrusions in the Karoo Basin, South Africa
Authors: Nengovhela V. , Linol B. , Bezuidenhout L. , Dhansay T. , Muedi T , de Wit M. 
Published: February 2021

Abstract
Contact metamorphism along widespread dolerite sills and dykes, emplaced at 182 to 183 Ma through the sedimentary host rocks of the Karoo Basin, triggered devolatilization of carbon-rich shales of the Lower Ecca Group. Hornfel samples collected from drill cores that intersect dolerite sills were analyzed for mineral phase equilibria, chemistry and porosity to characterize thermal aureoles at various distances from sill intrusions. Andalusite-chiastolite and cordierite porphyroblasts with biotite and muscovite occur within 10 to 20 m of many intrusive contacts. These metamorphic minerals crystallized when host shales attained maximum temperatures ranging between 450 and 600°C. Scanning electron microscopy imaging confirms that the hornfels are compact and that their metamorphic minerals limit porosity along grain boundaries. In few cases intra-mineral porosity occurs within individual crystals such as calcite, andalusite and cordierite. Disequilibrium metamorphic textures such as irregular grain boundaries, and inclusions in andalusite and cordierite reveal that the elevated temperatures were too short-lived to accomplish complete (re)crystallization. Thermal modeling results are consistent with the observed metamorphic mineral assemblages. Gas leakage calculations along a 7 m and a 47 m thick dolerite sill that intrude toward the top of the Whitehill Formation suggest that methane volumes ranging between 8 to 15 Tcf were generated during the sill emplacement. Methane was likely released into the atmosphere through hydrothermal vent complexes that are well preserved in the western Karoo Basin. If such loss was widespread across the entire basin, the implications for paleo-climate change and preserved shale gas reserves in the Karoo Basin of South Africa would be significant.
Authors: SYAHBANI M HUSNI 
Published: February 2021

Meningkatnya penggunaan pesawat tanpa awak atau drone di seluruh dunia memberikan masalah baru pada dunia penerbangan. Hal itu membuat lembaga penerbangan (aviation authority) di beberapa negara mengeluarkan aturan yang mengatur dan mengendalikan penggunaan drone. Jika tidak diatur, penggunaan drone yang tidak terkendali akan meningkatkan resiko yang membahayakan penerbangan khususnya penerbangan sipil. Peraturan keselamatan dan keamanan pengoperasian drone di Indonesia diatur dalam CASR 107. Dengan perkembangan teknologi informasi saat ini, implementasi peraturan tersebut dapat dikemas menjadi satu aplikasi mobile. Dalam makalah ini kami membahas tentang konsep software aplikasi mobile yang dapat digunakan untuk mengimplementasikan aturan tersebut. Konsep dasar software yang diajukan diadopsi dari konsep software B4UFLY yang dikembangkan lembaga penerbangan Amerika FAA
Campur Kode dan Struktur Bahasa Madura pada Tugas Menulis Teks Berita Siswa Kelas 8 SMP Negeri 1 Mayang
Authors: Astuti Noviarini Indah , Sofyan Akhmad , Badrudin Ali 
Published: February 2021

Penelitian ini bertujuan untuk mendeskripsikan wujud campur kode yang ditemukan pada hasil menulis teks berita dan struktur Bahasa Madura yang digunakan campur kode pada tugas menulis teks berita. Data yang digunakan dalam penelitian ini berupa kata yang mengindikasikan adanya wujud campur kode Bahasa Indonesia dan Bahasa Madura pada tugas menulis teks berita. Pada penelitian ini ditemukan fenomena campur kode dan penggunaan struktur Bahasa Madura dalam tugas menulis kembali teks berita yang telah dibaca. Wujud campur kode yang ditemukan pada tugas menulis teks berita siswa kelas 8 SMP Negeri 1 Mayang meliputi 1) campur kode berwujud kata berupa campur kode berwujud kata kerja, kata sifat, kata benda, kata tugas, dan 2) campur kode berwujud frasa. Struktur bahasa Madura yang ditemukan pada tugas menulis teks berita siswa kelas 8 SMP Negeri 1 Mayang anataralain 1) bentuk ulang/ reduplikasi, 2) konstruksi posesif, 3) konstruksi imperatif, 4) konstruksi “berlagak seperti orang...”, serta 5) morfofonemik prefiks N-
El régimen de la mita
Authors: Basadre Jorge 
Published: February 2021

El Estado español adoptó una actitud oscilante con respecto a los indios. No se trata aquí del problema teórico de si el indio podía ser reconocido como un ser dotado de razón. Este problema quedó resuelto en favor de la tesis afirmativa por una bula del Papa Paulo III y una serie de leyes. De allí se deduce en el fondo el precepto de la ley II del Libro VI de la Recopilación de Leyes de Indias, según el cual estaba permitido el matrimonio de indios y españoles y españoles e indias. Por cierto que, al mismo tiempo que hacían todas estas concesiones, las leyes no otorgaban a los indios una independencia absoluta o total.