bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of different adiposity factors on insulin resistance in obese children and adolescents
Authors: Niu Yang , Zhao Xuelin , He Huijun , Mao Xiaomeng , Sheng Jinye , Zou Jing , Tang Qingya , Cai Wei 
Published: February 2021

AbstractContextInsulin resistance (IR) has been common in obese children, but the effect of different adiposity factors on IR is still unclear.ObjectiveTo evaluate the associations between IR with body mass index (BMI), waist circumference (WC), body fat mass (BFM), and body fat percentage (BFP) in obese children and adolescents.MethodsA total of 224 simple obese children were included in this study, including 150 boys and 74 girls, aged 3‐18 who were seen in the clinical nutrition outpatient of Xinhua Hospital from September 2012 to December 2019. Basic information, body composition and laboratory tests were collected.ResultsCompared with girls, boys had higher height, weight, BMI, WC, and BFM (P < 0.05), but on the contrary, boys' FINS and HOMA‐ IR were lower than girls' (P > 0.05). With the age increasing, height, weight, BMI, BFM, WC, HC, WHtR, FINS and HOMA‐IR increased accordingly (P < 0.05). The results from univariate analysis and multiple linear regression analysis showed that the impact of BMI on IR was slightly lower than BFM, WC and HC, but higher than BFP, with adjusting for the effects of age, sex and lipid metabolism (P < 0.01).ConclusionOverall adipose tissue, especially abdominal adipose tissue, is a powerful marker in inducing IR in obese children and adolescents. In addition, more attention should be paid to WC and BFM than BMI in obese people with IR.
Novel rare variants in FGFR1 and clinical characteristics analysis in a series of congenital hypogonadotropic hypogonadism patients
Authors: Nie Min , Yu Bingqing , Chen Rongrong , Sun Bang , Mao Jiangfeng , Wang Xi , Zhang Hongbing , Wu Xueyan 
Published: February 2021

AbstractObjectiveWe aimed to analyse FGFR1 rare variants in a series of Chinese congenital hypogonadotropic hypogonadism (CHH) patients. In addition, we intended to understand the clinical characteristics and the response to treatment of CHH patients with FGFR1 rare variants.Patients and MethodsA total of 357 CHH patients were recruited at Peking Union Medical College Hospital. We used Sanger sequencing to analyse FGFR1 gene. In silico analysis was carried out to study the pathogenicity of novel missense variants. The clinical, endocrinological and therapeutic effects from patients carrying FGFR1 rare variants were analysed retrospectively.ResultsThimissense mutations.rty patients in this series were found to harbour 29 FGFR1 rare variants, with 8 recurrent and 21 novel variants. After comprehensive analysis, 18 out of 21 novel variants were classified as likely pathogenic (LP) ones. These variants are widely spread throughout the FGFR1 gene and almost all FGFR1 functional domains, which exhibited no hot spot. Cryptorchidism, cleft palate and dental abnormality incidence in this CHH series that possessed FGFR1 LP variants were approximately 38.5%, 7.6% and 3.8%, respectively. Among patients who accepted the fertility‐promoting treatment, 8 out of 10 patients succeeded in spermatogenesis.ConclusionsEighteen novel LP variants were found to expand the spectrum of FGFR1 rare variants. In CHH patients possessing FGFR1 variants, we found that the rate of spermatogenesis was high following fertility‐promoting therapy and the existence of cryptorchidism may represent the underlying factors which affect spermatogenesis.
Parametric Skeletons with Reduced Soft‐Tissue Deformations
Authors: Tapia Javier , Romero Cristian , Pérez Jesús , Otaduy Miguel A. 
Published: February 2021

AbstractWe present a method to augment parametric skeletal models with subspace soft‐tissue deformations. We combine the benefits of data‐driven skeletal models, i.e. accurate replication of contact‐free static deformations, with the benefits of pure physics‐based models, i.e. skin and skeletal reaction to contact and inertial motion with two‐way coupling. We succeed to do so in a highly efficient manner, thanks to a careful choice of reduced model for the subspace deformation. With our method, it is easy to design expressive reduced models with efficient yet accurate force computations, without the need for training deformation examples. We demonstrate the application of our method to parametric models of human bodies, SMPL, and hands, MANO, with interactive simulations of contact with nonlinear soft‐tissue deformation and skeletal response.>
The ethnic identity of transracially placed foster children with an ethnic minority background: A systematic literature review
Authors: Degener Clementine J. , van Bergen Diana D. , Grietens Hans W. E. 
Published: February 2021

AbstractBackgroundEthnic minority foster children are frequently placed in families with ethnic majority backgrounds. In the international literature these placements are most commonly called transracial placements.AimsWith this study, we aim to obtain an encompassing view of the empirical scientific literature on how transracial placements may affect the ethnic identity of foster children.Materials and methodsTo gain insight into the ethnic identity of transracially placed foster children and the way they are ethnically socialized, we conducted a systematic literature review. We thereby followed the guidelines of the PRISMA statement.ResultsTransracially placed foster children may experience higher fluctuations in their racial/ ethnic identity over time than adolescents with a minority background in the general population. They also seem to be prone to experience disconnection from, or on the contrary, connection with the birth network; and some transracially placed foster children struggle with societal messages they receive about minority ethnicity and race. They may have an increased awareness of their minority ethnic background because of different physical appearances between themselves and the foster family. Foster parents can play a pivotal role in these processes, since culturally competent foster parents may guide foster children in their ethnic identity development by being open towards children’s cultural minority background as well as being self‐reflective regarding their own cultural values and beliefs.DiscussionThe ethnic development of transracially placed foster children seems to be influenced by intersecting mechanisms of being in foster care and having a minority ethnicity. Although the selected articles assume that foster parents impact the ethnic identities of their ethnic minority foster children, none of them measured the impact of foster parents’ skills and knowledge on foster children’ s ethnic identity development directly.ConclusionBeing transracially placed impacts the ethnic identity of foster children. Foster parents need to be cultural competent to encourage their foster children’s ethnic identity development.
A new president in the White House: implications for Canadian agricultural trade
Authors: Grant Jason H. , Boys Kathryn A. , Xie Chaoping 
Published: February 2021

AbstractCanadian agricultural trade has experienced several volatile periods over the past 15 years. The Great Recession (2007–2009), the 2015–2016 global trade slowdown, unilateral policy actions by the United States against key trade allies and the multilateral system more generally, and the impacts of the Covid‐19 pandemic are among the most significant events during this period. Given the close integration of Canadian and US agricultural markets, the recent US election is likely to again impact the relative competitiveness of Canadian agricultural exports. While many observers suggest President‐elect Joe Biden will return to normal times regarding multilateral cooperation with key allies and international institutions such as the World Trade Organization, the new administration is likely to face headwinds given the significant fraying of ties with key trading partners and allies due to disruptive actions taken by his predecessor. This article provides an overview of potential implications of a Biden administration for Canada's agricultural trade. We start by reviewing recent trade shock events affecting Canada's agricultural trade with a particular focus on trade actions taken by the United States. Relevant components of the President‐elect Biden's platform, considerations affecting the implementation of this platform, and the implications of this for Canadian agricultural trade are considered.
Minimal invasive surgery for left colectomy adapted to the COVID‐19 pandemic: laparoscopic intracorporeal resection and anastomosis, a ‘don’t touch the bowel’ technique
Authors: Serra‐Aracil Xavier , Mora‐Lopez Laura , Gomez‐Torres Irene , Pallisera‐Lloveras Anna , Serra‐Pla Sheila , Serracant Anna , Garcia‐Nalda Albert , Pino‐Perez Oriol , Navarro‐Soto Salvador 
Published: February 2021

AbstractAimThe COVID‐19 pandemic has forced surgeons to adapt their standard procedures. The modifications introduced are designed to favour minimally invasive surgery. The positive results obtained with intracorporeal resection and anastomosis in the right colon and rectum prompt us to adapt these procedures to the left colon. We describe a ‘don't touch the bowel’ technique and outline the benefits to patients of the use of less surgically aggressive techniques and also to surgeons in terms of the lower emission of aerosols that might transmit the COVID‐19 infection.MethodsThis was an observational study of intracorporeal resection and anastomosis in left colectomy. We describe the technical details of intracorporeal resection, end‐to‐end stapled anastomosis and extraction of the specimen through mini‐laparotomy in the ideal location.ResultsWe present preliminary results of 17 patients with left‐sided colonic pathologies, 15 neoplasia and two diverticular disease, who underwent four left hemicolectomies, six sigmoidectomies and seven high anterior resections. Median operating time was 186 min (range 120–280). No patient required conversion to extracorporeal laparoscopy or open surgery. Median hospital stay was 4.7 days (range 3–12 days). There was one case of anastomotic leak managed with conservative treatment.ConclusionIntracorporeal resection and end‐to‐end anastomosis with the possibility of extraction of the specimen by a mini‐laparotomy in the ideal location may present benefits and also adapts well to the conditions imposed by the COVID‐19 pandemic. Future comparative studies are needed to demonstrate these benefits with respect to extracorporeal anastomosis.
Essential indicators for measuring site‐based conservation effectiveness in the post‐2020 global biodiversity framework
Authors: Geldmann Jonas , Deguignet Marine , Balmford Andrew , Burgess Neil D. , Dudley Nigel , Hockings Marc , Kingston Naomi , Klimmek Helen , Lewis Alanah Hayley , Rahbek Carsten , Stolton Sue , Vincent Claire , Wells Sue , Woodley Stephen , Watson James E. M. 
Published: February 2021

AbstractWork on the post‐2020 global biodiversity framework is now well advanced and will outline a vision, goals, and targets for the next decade of biodiversity conservation and beyond. For the effectiveness of Protected areas and Other Effective area‐based Conservation Measures, an indicator has been proposed for “areas meeting their documented ecological objectives.” However, the Convention on Biological Diversity (CBD) has not identified or agreed on what data should inform this indicator. Here we draw on experiences from the assessment of protected area effectiveness in the CBD's previous strategic plan to provide recommendations on the essential elements related to biodiversity outcomes and management that need to be captured in this updated indicator as well as how this could be done. Our proposed protected area effectiveness indicators include a combination of remotely derived products for all protected areas, combined with data from monitoring of both protected area management and trends in species and ecosystems based on field observations. Additionally, we highlight the need for creating a digital infrastructure to operationalize national‐level data‐capture. We believe these steps are critical and urge the adoption of suitable protected area effectiveness indicators before the post‐2020 framework is agreed in 2021.
Conservation, risk aversion, and livestock insurance: The case of the snow leopard
Authors: Loch‐Temzelides Ted 
Published: February 2021

AbstractLivestock insurance consists of livestock owners pooling resources together in order to hedge against the risk of attacks by predators on their individual herds. We use an economic model to study optimal livestock insurance and to discuss its viability in improving outcomes for livestock owners. The benefit from insurance depends on the livestock owners' level of risk aversion. We calibrate the model using data from Project Snow Leopard and investigate the potential of livestock insurance for achieving conservation goals. The model predicts that leopard killings would decline under the proposed livestock insurance contract. The level of the decline depends on the degree of risk aversion. Our analysis calls for surveys that measure risk aversion of local livestock owners to be conducted in any situation where insurance is considered as a policy towards achieving conservation goals. Finally, we discuss how the proposed livestock insurance scheme could be implemented in practice.
Paracicatricial melanocytes as a sign of melanoma
Authors: Ghanian Soha , Zakka Fouad R. , Shu Nova , Robinson‐Bostom Leslie , Weinstock Martin , Vezeridis Michael , Walker Joanna 
Published: February 2021

AbstractIntradermal melanocytes in the setting of melanoma represent a diagnostic challenge to dermatopathologists as their presence may represent superficially invasive melanoma vs benign nevus cells or reactive dermal melanocytes. Previous dermatologic literature suggests that the absence of cytologic atypia in intradermal melanocytes and their presence in nonmelanocytic neoplasms lends to their characterization as reactive, benign, melanocytic proliferation. A 67‐year‐old female presented for evaluation of a 10‐mm irregularly pigmented dark brown macule on the left cheek. Initial shave biopsy showed transected malignant melanoma measuring at least 0.6 mm in thickness. Multiple reexcision specimens demonstrated residual melanoma with banal appearing intradermal epithelioid melanocytes within and surrounding the scar. The melanocytes tracked into the skin graft, which had previously been free from involvement. Positron emission tomography–computed tomography (PET CT) and lymph node biopsies did not show evidence of metastatic melanoma. Ten months after her diagnosis and following five surgical excisions, the patient was diagnosed with metastatic melanoma to the brain and succumbed to intracranial hemorrhage. We present a case in which paracicatricial melanoma may simulate benign paracicatricial melanocytic hyperplasia. These findings have significant therapeutic and prognostic implications for the practicing dermatologist and dermatopathologist.
Substance use and help‐seeking among justice‐involved young people in Queensland and Western Australia: A cross‐sectional survey of 14–17‐year‐olds
Authors: Steele Megan L. , Meurk Carla , Schess Jaclyn , Yap Lorraine , Jones Jocelyn , Harden Scott , Davison Sophie , Butler Tony , Heffernan Ed 
Published: February 2021

AbstractIntroductionThis study investigated substance use and help‐seeking among justice‐involved young people to inform and improve service provision during and after contact with the justice system.MethodsYoung people (14–17 years) in the community with current or prior contact with the justice system were recruited in Queensland and Western Australia, Australia using purposive sampling between 2016 and 2018. A cross‐sectional survey was delivered by computer‐assisted telephone interview. Information was collected on sociodemographic and health factors; lifetime and frequency of use of alcohol, tobacco and other drugs; and use of health services related to substance use and mental health.ResultsOf the 465 justice‐involved young people surveyed, most had used alcohol (89%), tobacco (86%) or other drugs (81%). Of the latter, cannabis use was most prevalent (79%), followed by ecstasy (26%) and amphetamine (22%). Young people engaging in higher risk drug use (daily use, injecting use) were more likely to also have an alcohol use disorder, be disengaged from education, unemployed, have attempted suicide and experienced incarceration. Of the cohort, 24% had received treatment at an alcohol and drug service in the past year and 30% had seen a health professional about emotional/behavioural problems. Males and Aboriginal and Torres Strait Islander young people were less likely to have sought professional help.ConclusionThe high levels of substance use and disproportionate levels of help‐seeking observed in this study illustrate the importance of delivering tailored, comprehensive and coordinated trauma‐informed and culturally safe alcohol and drug services to justice‐involved young people.
The role of phylogenetic scale in Darwin's naturalization conundrum in the critically imperilled pine rockland ecosystem
Authors: Trotta Lauren B. , Siders Zachary A. , Sessa Emily B. , Baiser Benjamin 
Published: February 2021

AbstractAimWe expand on community phylogenetic approaches to Darwin's Naturalization Conundrum by considering phylogenetic scale, comprised of phylogenetic grain and extent. We assess relatedness between invasive, non‐native and native plant species at multiple depths in the phylogeny (i.e. phylogenetic grain) and across multiple clades (i.e. phylogenetic extents) at regional and local spatial scales in the highly fragmented, critically imperilled pine rockland ecosystem.LocationMiami‐Dade County, Florida, USA.MethodsWe used two metrics differing in phylogenetic grain to determine whether invasive or non‐native species were more closely related to native species in the regional pool and at 33 habitat fragments. At both spatial scales, we altered phylogenetic extent from all vascular plants to four smaller phylogenetic domains (Monilophyte, Gymnosperm, Monocotyledon and Dicotyledon) and assessed whether the interpretation of relatedness changed.ResultsFor the regional pool and at a broad phylogenetic grain, non‐native species were more closely related to the native community than invasive species were for all phylogenetic extents (i.e. support for Darwin's Naturalization Hypothesis, DNH), and at a fine phylogenetic grain for only two phylogenetic extents. At the local scale, there was limited support for DNH across all phylogenetic extents. In Monocotyledons, support for DNH was more prevalent at the fine phylogenetic grain, while Dicotyledons showed support for DNH at the broad phylogenetic grain.Main conclusionsIn the pine rockland flora, we found either support for DNH or no difference in relatedness between non‐native‐to‐native and invasive‐to‐native species. However, patterns of relatedness varied across spatial and phylogenetic grain and, critically, this variability is highly dependent on the phylogenetic extent considered. By explicitly assessing the interactions between spatial scale and phylogenetic scale, we show that support for DNH was context dependent, and findings at smaller phylogenetic extents rarely agreed with findings at the larger phylogenic extent.
Pairing functional connectivity with population dynamics to prioritize corridors for Southern California spotted owls
Authors: Conlisk Erin , Haeuser Emily , Flint Alan , Lewison Rebecca L. , Jennings Megan K. 
Published: February 2021

AbstractAimLand use change, climate change, and shifts to disturbance regimes make successful wildlife management challenging, particularly when ongoing urbanization constrains habitat and movement. Preserving and maintaining landscape connectivity is a potential strategy to support wildlife responding to these stressors. Using a novel model framework, we determined the population‐level benefit of a set of identified potential corridors for spotted owl population viability.LocationSouthern California, United States.MethodsCombining habitat suitability and dynamic metapopulation models, we compared the benefit of corridors to the Southern California spotted owl population, measured as the increase in the expected minimum abundance, both now and under a future climate. Our approach considered key corridor characteristics important to conservation decisions, namely corridor irreplaceability and local population network benefit.ResultsWe identified two corridors likely to increase Southern California spotted owl expected minimum abundance under current climate conditions. At the regional scale, of the 27 corridors evaluated, one corridor was irreplaceable (i.e., no other corridors in the network could provide a similar increase in abundance when the irreplaceable corridor was removed) and one corridor was identified as redundant (i.e., remaining corridors in the network can provide some of the increases in abundance offered by the removed corridor). Both putative corridors connected two large, populous and similarly sized patches. Additionally, we identified two more corridors at the local scale. We found that, under climate change, population declines may limit the benefit of connectivity for a range‐restricted species like the spotted owl.Main conclusionsOur analytical approach highlights important criteria for corridor identification and prioritization, namely irreplaceability versus redundancy, local versus regional benefit, and corridor impact in a changing landscape. With the capability of incorporating estimated functional connectivity into population dynamics, our modelling framework advances connectivity decision‐making for other species of conservation concern and archetypal taxa within ecological communities.