bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Mindfulness in Promoting Subjective Wellbeing and Mood Homeostasis in Patients with Crohn’s Disease
Authors: Lyall Kimina 
Published: November 2021

Background: The relationship between stress, symptoms of inflammatory bowel disease (IBD), and depression has not previously been considered using the theory of subjective wellbeing (SWB) homeostasis as a conceptual framework. It is proposed that mindfulness, as a mechanism of down-regulating challenging emotion, can aid in the restoration of mood homeostasis and reduce symptoms of both psychological and physiological stress. The study aims to identify whether individuals with Crohn’s disease (CD) and co-occurring psychological depression or stress are experiencing the defeat of SWB homeostasis. Further, the study aims to test whether a Mindfulness Based Stress Reduction (MBSR) intervention can restore homeostasis. The study would also identify whether this restoration of homeostasis is associated with a reduction in disease symptomatology.
Methods/Design: An exploratory randomised control trial with 40 participants recruited from public health gastroenterology patients and randomly allocated to an 8-week MBSR program or wait-list control. Measures of SWB, depression, stress, and C-reactive protein (CRP) levels will be collected prior to and after the intervention. Individual HPMood set points will be determined from affect data collected over 7 days through momentary sampling techniques prior to the commencement of the intervention. Measures will be repeated at 6-month follow-up. Following this, the wait-list group will be offered the same 8-week MBSR. Hypotheses will be tested using mixed ANOVA and clinical significance tests.
Discussion: This study will be an important contributor to knowledge about psychological vulnerability and resilience for people with CD and will provide initial evidence that could contribute to the development of a larger future trial.
Diagnosis of Hordeum vulgare Genomic Profile: Review
Authors: Al-Hadeithi Zeina S. M. , Jasim Saade Abdalkareem 
Published: November 2021

This review represent plants genetic diversity (PDG) generally in crop plant and especially in Barley (Hordeum vulgare), can be studied (PDG) and stored as a (PGR) plant genetic resources as gene bank , DNA library for saved genetic material at long time and crops improvement can be utilized in breeding programs strategies in future. In this study observed the significance of plant genetic diversity (PGD) and (PGR) especially on agriculturally important crops , analysis of plant genomic using molecular markers. Barley is a well important studies crops using as a model for study genetic plant, cultivated barley Hordeum vulgare easily hybridization by genetic fingerprinting with wiled barley Hordeum spontaneum. The molecular markers showed their relation with locus of geographic factors and imposed stresses. Here, discussed barley genomic through relationship between genotype and phenotype traits using molecular markers useful for genetic physiological maps construction.
Comparative Study of the Safety and Chemical Composition of Commercially Available Fruit Juices and Soft Drinks in Southwest Nigeria
Authors: Bolarinwa Islamiyat Folashade , Oladepo Segilola Maryam , Adesola Mary Oluwatosin , Qadri Sekinat 
Published: November 2021

Aims: Fruits juices and soft drinks are among the most important and convenient foods which are commonly consumed to quench thirst, and as a source of micronutrients. However, most fruit juices commercially sold in Nigeria are not pure juice but contains additives which may affect the safety and quality attributes of the product. This study therefore, evaluated the chemical composition and microbiological safety of some commercially sold fruit juices and drinks and compared their quality with pure fruit juices.
Methodology: Twenty commercially sold fruit juices and soft drinks were analyzed for physicochemical properties, vitamins and minerals composition and microbiological quality using standard analytical procedures.
Results: Pure fruit juices contain similar pH, total titratable acidity, and specific gravity as the commercial fruit juices and soft drinks, but significantly higher total solid contents. The total soluble solid recorded for the pure pineapple (22 g/100ml) and watermelon juice (25.9 g/100ml) were significantly higher than the values (11.1 – 15.5g/100ml) recorded for the commercial fruit juices. The vitamin C content of the commercial soft drink ranged from 22.94 to 26.14 μg/100g, and that of commercial fruit juices and pure fruit juice ranged from 14.89 to 22.81μg/100g with pure fruit juice having the lowest value.
Conclusion: The physicochemical properties of the pure fruit juice and commercial fruit and soft drinks were similar except for total solids and Brix level. Commercial fruit juices and soft drinks contain higher vitamins and minerals than pure fruit juices due to addition of synthetic vitamins and minerals. All the commercial fruit juice samples and soft drinks are free of microbial loads and would not cause any health problems if properly handled after purchase. The study recommends the consumption of hygienically prepared pure fruit juices because they are free from synthetic micronutrients.
Level of Anxiety among the Mothers of Preterm Newborn Admitted in Nicu Ward
Authors: Patel Rupal , Soni Nirali , Patel Krishna , Patel Mahima , Patel Mansi , Patel Megha 
Published: November 2021

Background: Premature birth has a great impact on the parents. In India, 27 million babies are born each year out of which 3.5 million babies are born premature. This study included premature infants <37 weeks of gestation. Preterm birth may have a negative impact on parents’ experience as well In fact, the premature birth of the baby suddenly interrupts the building of parents’ mental representations and expectations.
Aim and Objective: The purpose of this study was to assess the level of anxiety among the mothers of preterm newborn admitted in NICU ward and to find out the association between the level of anxiety among the mothers of preterm newborn with their demographic variable.
Design and Methods: A descriptive study was carried out on 50 mothers of premature newborn. Who were admitted to the neonatal intensive care unit of selected hospital, vadodara. Purposive sampling technique was used to collect the data. Descriptive and inferential statistics were applied to analyses the data by using SPSS-20 software. The samples in this study was selected by non randomised sampling technique. Mothers anxiety regarding the newborn were determined by Hamilton anxiety rating scale. Data was collected by applying Inclusion Criteria like Mothers of preterm who were willing to participate , who were admitted in the hospital.
Results: The majority of mothers the study finding of qualitative data reveals that the mothers level of anxiety 10% mild, 10% moderate, 22% severe, 58% very severe. The linear regression analysis showed that anxiety level was at significance of 0.05 level. Association between age and birth weight in demographic variables.
Conclusion: The present study concluded level of anxiety 10% mothers of having mild anxiety, 10% were having moderate anxiety, 22% were having severe anxiety, 58% were having very severe anxiety. The linear regression analysis showed that anxiety level was at significance of 0.05 level.
Knowledge and Awareness about the Connection between Lifestyle and Dementia among Adolescents
Authors: Arora Dev , Devi R. Gayatri , Priya A. Jothi 
Published: November 2021

Background and Aim: Dementia is a group of symptoms characterized by memory loss, judgemental loss, forgetfulness. Dementia cannot be cured; but can be prevented. There are seven stages of Dementia, no cognitive decline being the first stage to very severe cognitive decline being the seventh stage. Healthy lifestyle is important for lower risk of Dementia. Smoking, consumption of alcohol, negative thinking, depression, stress, anxiety, lack of sleep, unhealthy diet causes Dementia. Diet plays a very important role in prevention of dementia; foods such as red meat, sugar, fatty foods can increase the risk of dementia whereas foods rich in fibres, fruits can reduce the risk of Dementia. The main aim of this study is to assess the knowledge about lifestyle and dementia.
Materials and Methods: This is a cross sectional survey. 121 adolescents of Saveetha Dental College, Chennai participated in the survey which was conducted through Google forms in February 2021. The questionnaire consisted of 19 questions. The data was analyzed with the help of SPSS software and chi-square test was done for the correlation between gender and awareness. Chi-square test was done for the correlation of gender with awareness among the population. ‘p-value’ was calculated and value < 0.05 was considered as significant.
Results: Out of that 62 were females and 59 were males. Females were more aware about healthy lifestyles and its connection with dementia than males. 92.56% of people were aware that physical activity promotes a healthy brain. 69.2% agreed that depression can increase risk of Dementia. Majority of them agreed that physical exercise can promote a healthy brain.
Conclusion: This study revealed that lifestyle is highly associated with dementia among adolescents. Healthy lifestyle leads to lower risk of dementia even if there’s high genetic risk. Females were aware about the diet which is healthy for lower risk of dementia and more smoking affects the memory. However, most of the people were neutral about the relation between BMI and Dementia.
Knowledge, Attitude and Awareness on Effect of Air Pollution on Children among Parents
Authors: Krishna B. Ashwin , Devi R. Gayatri , Priya A. Jothi 
Published: November 2021

Introduction: The World Health Organisation [WHO] recommended that breathing clean air reduces the risk of diseases such as Asthma and Lung cancer. Inhaling low quality of air causes several health problems such as headaches, nausea and tiredness. The main aim of this study is to create awareness among parents about the effect of air pollution on children.
Materials and Methods: This is a cross sectional survey study. The standard questionnaire was prepared and distributed as Google forms to nearly 100-120 parents. The population was randomly selected. A self-administered structured questionnaire was prepared based on Knowledge attitude and awareness on effects of air pollution on children among parents. It was circulated to participants through an online platform (google forms). The statistics were done using SPSS software, chi square test was used to check the association and P value of 0.05% was said to be statistically significant.
Results: 78.53% of the populations were aware that air pollution affects cognitive ability. 50.98% of the population responded that exposure of polluted air to pregnant female’s cause’s premature birth. 45.28% of females were aware that air pollution affects neutron development in the brain. As a result of this study most of the parents were aware about air pollution and its effects on their children.
Conclusion: In this study females were slightly more aware about air pollution than males. If this awareness persists among all the people in the society many harmful effects such as air pollution and other related problems can be solved.
Survey on HBV Immunisation Status among the Dental Practitioners
Authors: Kishore R. N. Arun , Muralidharan N. P. 
Published: November 2021

Introduction: There are more than 2 billion people worldwide who have evident recent or past HBV infection and chronic cases. Hepatitis B, C and D are transmitted by parental contact with infected body fluids including blood, semen, saliva , sweat and tears , invasive medical procedures using equipment which are contaminated with the virus , vertical transmission. Hepatitis B vaccine is a vaccine that prevents hepatitis B. The first dose is recommended within 24 hours of birth with either two or three more doses given after that. This includes those with immunisation such as from AIDS/HIV and those born premature. It is also recommended that health-care workers be vaccinated. In healthy people routine immunisation results in more than 96% of the people being protected.
Aim: The aim of this study is to know the immunisation status and knowledge and awareness among dental practitioners.
Materials and Methods: A survey was designed to analyse the result. The questionnaire was prepared in Google Forms (online survey link) and was distributed to 100 dental practitioners. The responses were then collected and statistically analysed using SPSS software.
Results and Discussion: After discussing the results of the present study, it was seen that many were aware of hepatitis B vaccine. Limitations of this are that the population is small. Limitations seen in this study can be included in future research for better spread of awareness among the general public.
Conclusion: From the study we can conclude that the majority of the dental practitioners are aware of hepatitis B vaccine and are aware of their vaccination status of hepatitis B.
In silico Analysis of a Novel Peptide Vaccine against Hepatitis B Virus (HBV)
Authors: Sundar R. , Ganesh P. Sankar , Girija A. S. Smiline , Priyadharshini J. Vijayashree 
Published: November 2021

Background : Hepatitis B is a potentially life-threatening liver infection caused by the Hepatitis B virus (HBV). It is a major global health problem and the most serious type of viral hepatitis. It can cause chronic liver disease and puts people at high risk of death from cirrhosis of the liver and liver cancer. HBV is found in highest concentrations in blood and in lower concentrations in other body fluids.
Methods: Target protein was retrieved from the swissprot database. Epitopes were predicted using the BCEPRED server. After running the BLAST algorithm for the target protein, the template with the best identity was selected. After modeling, target protein is verified by using the swiss model workspace and after this process the obtained target protein is allowed to interact with the MHC which is studied by using patchdock, finally these results were viewed by using the deepview tool.
Results: The target protein for vaccine development was downloaded from the SwissProt database. Its SwissProt ID was p29178. The protein was isolated from hepatitis B virus genotype G. The virus was isolated from the United States of America. The length of the target protein was found to be 195 amino acids. To confirm that the target protein could be used for vaccine development, the Presence of epitopes in the protein was confirmed using the BCEPRED tool. Results from the SAVS server showed 95.80 of the residues of the protein had an average 3D-1D score greater than 0.2. The protein attained a pass with an ERRAT value of 90.299.
Conclusion: The present investigation recognized the promising complex formed between the HBV peptide and MHC molecules. All the downloaded MHC molecules were found to interact with the target protein through the formation of hydrogen bonds. Since these interactions are necessary during an immune response to invading pathogens, the target protein would ultimately trigger an immune response if it is administered as a vaccine for Hepatitis B virus genotype G.
To Compare the Efficacy of Betamethasone Gel and Lignocaine Gel Applied over Endotracheal Tube to Reduce Post Operative Sore Throat and Cough
Authors: Imayaval S. , Sanjana K. V. L. 
Published: November 2021

Background: Post-operative sore throat, cough and hoarseness of the voice are often common, uncomfortable sequelae after tracheal intubation with inflammation being the most common pathogenesis. Post operative sore throat and cough has a multifactorial aetiology that includes patient-related factors such as age, sex, and smoking, as well as intubation factors such as technique, duration, tube size, intracuff pressure, cuff design, trauma to the pharyngolaryngeal mucosa and various factors.
Objectives: To compare the incidence of post operative sore throat, cough after endotracheal tube intubation when applying betamethasone gel and lignocaine jelly.
Materials and Methods: At Saveetha Medical College and Hospital in Thandalam, Chennai, a prospective controlled double blinded study was done among patients who were scheduled for elective procedures under general anaesthesia with orotracheal intubation. The study comprised 60 patients who met the study's inclusion and exclusion criteria. The 60 patients were divided into two study groups each enrolled with 30 patients. Before the study could begin, approval from the institutional research board was required. Before the study began, an informed, written consent was obtained. The method used was Qualitative observational randomised double blind study by using a computer-generated random number table and the sealed envelope approach, patients were assigned to one of two equal groups.
Following a pre-anaesthetic evaluation, 60 patients of either sex, aged 18 to 60 years, with an ASA physical status of I or II, who were undergoing elective surgery (likely to last up to 240 minutes) under general anaesthesia with orotracheal intubation and met the above inclusion criteria were included in the study. The differences between the study groups were analysed by chi square test and the “p” value used as a cut off for estimating statistical significance between groups is 0.05.
Results: The incidence and severity of post operative sore throat and cough after endotracheal intubation during 6 and 24 hours was found to be statistically significantly in patients in whom betamethasone was used. The results are significant at p<0.05.
At 6 hours the incidence of post operative sore throat for betamethasone and lignocaine was 12% and 30% respectively. At 24 hours the incidence of post operative sore throat for betamethasone and lignocaine was 9.36% and 25.2% respectively.
At 6 hours the incidence of post operative cough for betamethasone and lignocaine was 8.4% and 24%.At 24 hours the incidence of post operative cough for betamethasone and lignocaine was 7.2% and 21.6% respectively.
Conclusion: The use of 0.05 percent betamethasone gel to lubricate the endotracheal tube before intubation helps to reduce the time it takes for symptoms to resolve.
In vitro Evaluation of Antimicrobial Activity of Opuntia ficus-indica Seed Oil
Authors: Mohamed Naz Fathima Raj , Geetha R. V. , Ganesh P. Sankar 
Published: November 2021

Introduction: Opuntia ficus-indica is a well adapted cactus to extreme climatic environments. In the usual diet and food industry, it is an interesting source of food ingredients. In general, the protective role of prickly pears has been due to their antioxidant components, phenolic compounds, and some minor components present in the content of seed oil and seed protein and the oil from cactus pear seed has been found with high levels of unsaturated fatty acids ,with antioxidant and antimicrobial activity as well as cardioprotective, antithrombotic, anti-inflammatory, antiarrhythmic, hypolipidemic, and antihyperglycemic effect.
Aim: To evaluate the in vitro antimicrobial activity of Opuntia ficus-indica seed oil against Streptococcus mutans.
Materials and Methods: Broth microdilution assay was performed by following modifications: Brain heart infusion (BHI) broth was prepared and sterilise at 121c for 15lbs, the 100 microlitre of streptococcus mutans inoculated at freshly prepared broth and incubated at 37c for 24 hours. Then BHI broth prepared with sucrose and serial two fold dilution were done with 160microlitre broth and 40 microlitre prickly pear seed oil. Then 20 microlitre of culture was added. Column 11 contains BHI using sterile micro pipettes and the plates were incubated at 30 c for 18 hours. The growth of bacteria was visualised and lowest concentration with no visible growth was recorded as MIC.
Results: This study results shows that, by broth microdilution method at concentration ranging from 10%-0.039% v/v, Opuntia ficus-indica seed oil potentially inhibits the growth of streptococcus mutans at the concentration of 0.03% (v/v).
Conclusion: From the study, the results demonstrated that Opuntia ficus-indica seed oil shows noticeable antimicrobial activity against streptococcus mutans. Use of essential oils against oral pathogens can be an alternative to other antimicrobial agents which could be cheap and effective modules used in control of bacteria which are responsible for oral infections.
Detection of Immuno Dominant Peptides against pgaB of Acinetobacter baumannii
Authors: Indumathi M. , Girija A. S. Smiline , Ganesh P. Sankar , Priyadharsini J. Vijayashree 
Published: November 2021

Background: Acinetobacter baumannii is a gram negative non-motile coccobacillus, which was considered as a low priority pathogen with low virulence. Recently, it was declared as the priority pathogen under the critical category of the most dangerous pathogen by WHO. Acinetobacter Baumannii is an inhabitant of oral biofilms, and it also increases the risk of refractory periodontitis. It causes nosocomial infections with pgaB, a part of pgaABCD operon which is involved in the biofilm formation.
Aim: The aim of the present study was to detect the immunodominant peptides against pgaB of Acinetobacter baumannii using bioinformatic tools and databases.
Materials and Methods: The present study was carried out using immune informatics. The protein sequence of the pgaB protein from A.baumannii was subjected to assess allergenicity, secondary structure, antigenicity and stability prediction of selected T cell epitopes, physico-chemical analysis, Identification of MHC class 2 binders, Final selection of B-cell epitopes was done with IEDB B-cell epitope tool
Results: Final docking of the peptides were interpreted by hydrogen bonds and interac- tion scores with TLR-2. Promising scores on antigenicity, instability were obtained. Based on the combinatorial scores, one vaccine peptide (LNLTLGLAL) was suggested to be a promising vaccine candidate against pgaB of A.baumannii.
Conclusion: The findings of the present study suggest epitope LNLTLGLAL as a promising vaccine candidate against pgaB of A.baumannii. The vaccine peptides targeting the pgaB Gene in A.baumannii using an immune-informatics approach suggests promising results in the present study. However, the predicted epitope peptides need further experimentation in animal models for its application against A.baumannii.