bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of cabazitaxel on macrophages improves CD47-targeted immunotherapy for triple-negative breast cancer
Authors: Cao Xu , Li Bolei , Chen Jing , Dang Jessica , Chen Siqi , Gunes E Gulsen , Xu Bo , Tian Lei , Muend Sabina , Raoof Mustafa , Querfeld Christiane , Yu Jianhua , Rosen Steven T. , Wang Yingyu , Feng Mingye 
Published: March 2021

BackgroundLimited therapeutic options are available for triple-negative breast cancer (TNBC), emphasizing an urgent need for more effective treatment approaches. The development of strategies by targeting tumor-associated macrophages (TAMs) to stimulate their ability of Programmed Cell Removal (PrCR) provides a promising new immunotherapy for TNBC treatment.MethodsCD47 is a critical self-protective “don’t eat me” signal on multiple human cancers against macrophage immunosurveillance. Using human and mouse TNBC preclinical models, we evaluated the efficacy of PrCR-based immunotherapy by blocking CD47. We performed high-throughput screens on FDA-approved anti-cancer small molecule compounds for agents potentiating PrCR and enhancing the efficacy of CD47-targeted therapy for TNBC treatment.ResultsWe showed that CD47 was widely expressed on TNBC cells and TAMs represented the most abundant immune cell population in TNBC tumors. Blockade of CD47 enabled PrCR of TNBC cells, but the efficacy was not satisfactory. Our high-throughput screens identified cabazitaxel in enhancing PrCR-based immunotherapy. A combination of CD47 blockade and cabazitaxel treatment yielded a highly effective treatment strategy, promoting PrCR of TNBC cells and inhibiting tumor development and metastasis in preclinical models. We demonstrated that cabazitaxel potentiated PrCR by activating macrophages, independent of its cytotoxicity toward cancer cells. When treated with cabazitaxel, the molecular and phenotypic signatures of macrophages were polarized toward M1 state, and the NF-kB signaling pathway became activated.ConclusionThe combination of CD47 blockade and macrophage activation by cabazitaxel synergizes to vastly enhance the elimination of TNBC cells. Our results show that targeting macrophages is a promising and effective strategy for TNBC treatment.
Role of depressive symptoms in cardiometabolic diseases and subsequent transitions to all-cause mortality: an application of multistate models in a prospective cohort study
Authors: Qiao Yanan , Liu Siyuan , Li Guochen , Lu Yanqiang , Wu Ying , Ding Yi , Ke Chaofu 
Published: March 2021

Background and purposeThe role of depression in the development and outcome of cardiometabolic diseases remains to be clarified. We aimed to examine the extent to which depressive symptoms affect the transitions from healthy to diabetes, stroke, heart disease and subsequent all-cause mortality in a middle-aged and elderly European population.MethodsA total of 78 212 individuals aged ≥50 years from the Survey of Health Ageing and Retirement in Europe were included. Participants with any baseline cardiometabolic diseases including diabetes, stroke and heart disease were excluded. Depressive symptoms were measured by the Euro-Depression scale at baseline. Participants were followed up to determine the occurrence of cardiometabolic diseases and all-cause mortality. We used multistate models to estimate the transition-specific HRs and 95% CIs after adjustment of confounders.ResultsDuring 500 711 person-years of follow-up, 4742 participants developed diabetes, 2173 had stroke, 5487 developed heart disease and 7182 died. Depressive symptoms were significantly associated with transitions from healthy to diabetes (HR: 1.12, 95% CI: 1.05 to 1.20), stroke (HR: 1.31, 95% CI: 1.18 to 1.44), heart disease (HR: 1.26, 95% CI: 1.18 to 1.34) and all-cause mortality (HR: 1.41, 95% CI: 1.34 to 1.49). After cardiometabolic diseases, depressive symptoms were associated with the increased risk of all-cause mortality in patients with diabetes (HR: 1.54, 95% CI: 1.25 to 1.89), patients who had stroke (HR: 1.29, 95% CI: 1.03 to 1.61) and patients with heart disease (HR: 1.21, 95% CI: 1.02 to 1.44).ConclusionsDepressive symptoms increase the risk of diabetes, stroke and heart disease, and affect the risk of mortality after the onset of these cardiometabolic conditions. Screening and treatment of depressive symptoms may have profound implications for the prevention and prognosis of cardiometabolic diseases.
Chapter 5.3a Mount Early and Sheridan Bluff: volcanology
Authors: Smellie John L. , Panter Kurt S. , Reindel Jenna 
Published: March 2021

Abstract

Two small monogenetic volcanoes are exposed at Mount Early and Sheridan Bluff, in the upper reaches of Scott Glacier. In addition, the presence of abundant fresh volcanic detritus in moraines at two other localities suggests further associated volcanism, now obscured by the modern Antarctic ice sheet. One of those occurrences has been attributed to a small subglacial volcano only
c.
200 km from South Pole, making it the southernmost volcano in the world. All of the volcanic outcrops in the Scott Glacier region are grouped in a newly defined Upper Scott Glacier Volcanic Field, which is part of the McMurdo Volcanic Group (Western Ross Supergroup). The volcanism is early Miocene in age (
c.
25–16 Ma), and the combination of tholeiitic and alkaline mafic compositions differs from the more voluminous alkaline volcanism in the West Antarctic Rift System. The Mount Early volcano was erupted subglacially, when the contemporary ice was considerably thicker than present. By contrast, lithologies associated with the southernmost volcano, currently covered by 1.5 km of modern ice, indicate that it was erupted when any associated ice was either much thinner or absent. The eruptive setting for Sheridan Bluff is uncertain and is still being investigated.
Application and Clinical Analysis of Remote Fetal Heart Rate Monitoring Platform in Continuous Fetal Heart Rate Monitoring Images
Authors: Yang Xuan , Zhang Ke , He Jianhu 
Published: March 2021

Fetal heart sound is an important part of fetal monitoring and has attracted extensive research and attention from scholars at home and abroad in recent years. The fetal heart rate, extracted from the fetal heart sound signal, is one of the important indicators that reflect the health of the fetus in the womb. In this study, a maternal-fetal Holter monitor based on f ECG technology was used to collect maternal heart rate, fetal heart rate, and uterine contractions signals, isolate the fetal heart rate, and design an algorithm to extract the fetal heart rate baseline, acceleration, variation, wake-up cycle, and nonlinear parameters. Using statistical methods to analyze the average value and range of various characteristic parameters of fetal heart rate under continuous long-term monitoring, the results show that the baseline has a downward trend from 10 o’clock in the night to 4 o’clock in the morning and is the lowest around 2 o’clock in the morning. The area and acceleration time were significantly higher than those in the suspicious group. However, there was no significant difference in the number of acceleration values between the two groups; the proportion of small mutations in the normal group was lower than that of the suspicious group and the proportion of medium mutations was higher than that of the suspicious group. There is no statistically significant difference in maternal age, gestational age at childbirth, pregnancy comorbidities, and complication rates in the five-level interpretation system of ACOG (2009), RCOG (2007), SOGC (2007), and the United States (2007). The difference of pregnancy and parity in various images was statistically significant,

P

< 0.05. The second type of fetal heart rate monitoring images appeared in the highest among the diagnostic standards, and the difference in the second type of fetal heart rate monitoring images between the various diagnostic standards was statistically significant,

P

≤ 0.001.
Abnormal Left‐Hemispheric Sulcal Patterns in Adults With Simple Congenital Heart Defects Repaired in Childhood
Authors: Asschenfeldt Benjamin , Evald Lars , Yun Hyuk Jin , Heiberg Johan , Østergaard Leif , Grant P. Ellen , Hjortdal Vibeke Elisabeth , Im Kiho , Eskildsen Simon Fristed 
Published: March 2021

Background
Children operated on for a simple congenital heart defect (CHD) are at risk of neurodevelopmental abnormalities. Abnormal cortical development and folding have been observed in fetuses with CHD. We examined whether sulcal folding patterns in adults operated on for simple CHD in childhood differ from those of healthy controls, and whether such differences are associated with neuropsychological outcomes.

Methods and Results

Patients (mean age, 24.5 years) who underwent childhood surgery for isolated atrial septal defect (ASD; n=33) or ventricular septal defect (VSD; n=30) and healthy controls (n=37) were enrolled. Sulcal pattern similarity to healthy controls was determined using magnetic resonance imaging and looking at features of sulcal folds, their intersulcal relationships, and sulcal graph topology. The sulcal pattern similarity values were tested for associations with comprehensive neuropsychological scores. Patients with both ASD and VSD had decreased sulcal pattern similarity in the left hemisphere compared with controls. The differences were found in the left temporal lobe in the ASD group and in the whole left hemisphere in the VSD group (
P
=0.033 and
P
=0.039, respectively). The extent of abnormal left hemispheric sulcal pattern similarity was associated with worse neuropsychological scores (intelligence, executive function, and visuospatial abilities) in the VSD group, and special educational support in the ASD group.

Conclusions
Adults who underwent surgery for simple CHD in childhood display altered left hemisphere sulcal folding patterns, commensurate with neuropsychological scores for patients with VSD and special educational support for ASD. This may indicate that simple CHD affects early brain development.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03871881.
Role of Option of Defect in Tenders: A Study under Omani Law
Authors: al-Qassaymeh Maen Mohammad , AlOmran Nayel Musa Shaker 
Published: March 2021

Abstract
Option of defect is an important theory regulated in Omani Civil Law. It gives the injured party in bilateral contracts an option to rescind the contract if they find a defect in the subject matter of the contract. This theory is deemed a legal basis to refuse objects of sale by tender. In particular, it is useful when a guarantee that is given to the governmental body is insufficient to cover damages, due to bad performance of the contract. This article discusses how the option of defect is applied to sale by tender in Omani law.
الغنى مفهوما أخلاقيا عند الصوفية إلى حدود نهاية القرن السابع الهجري
Authors: Harrous (حفيظ هروس) Hafid 
Published: March 2021

الخلاصة
يعتبر الغنى من المفاهيم المهمة في حقل التصوف، فقد طوّره الصوفية ليفيد العديد من المدلولات الأخلاقية، ولم ينظروا إليه فقط باعتباره مقاما يسعى السالك لتحصيله في خويصة نفسه، ولكن أيضا باعتباره خلقا للتعامل مع الناس، وتعاليا للنفس عن الانبهار بمظاهر الإثراء المادي، وهو بذلك يُجيب على الكثير من التحديات والأمراض التي تطرحها الاضطرابات السلوكية المرتبطة بالقيم المادية، ويمكن أن يُشكل مدخلا لأخلاقيات المعالجات النفسية لأمراض التملك. لكن قبل أن يستقر هذا المفهوم على هذه الدلالات مرّ بمراحل عديدة في حياته الدلالية، ابتداء من القرآن والسنة والشعر العربي المبكر، ووصولا إلى الأدبيات والطرق الصوفية المكتملة نظريا والمنظمة عمليا‫.‬
<p><strong><em>Clerodendrum angustipetalum</em>, a new species of <em>Clerodendrum</em> (Lamiaceae) from Thailand</strong></p>
Authors: SATTHAPHORN JIRATTHI , PATON ALAN J. , LEERATIWONG CHARAN 
Published: March 2021

Clerodendrum angustipetalum (Lamiaceae), an endemic species to Narathiwat province, southern Thailand, is described and illustrated as a species new to science. It is similar to C. nutans in having an elongate pendulous inflorescence, but essentially differs in the thicker leaf texture (subcoriaceous vs membranaceous), the calyx tube being almost twice as long and the corolla lobes being half as broad. In addition, the new species has longer calyx lobes, corolla lobes and stamens. The conservation status of this species is assessed as Critically Endangered (CR, B2a + b(ii, iii)+C2ai+D) due to being known from a single locality with a small population of less than 50 individuals. A morphological comparison between similar species and an updated key to Clerodendrum species with pendulous inflorescences from southern Thailand is also presented.
Bianchiniite, Ba2(Ti4+V3+)(As2O5)2OF, a new diarsenite mineral from the Monte Arsiccio mine, Apuan Alps, Tuscany, Italy
Authors: Biagioni Cristian , Pasero Marco , Hålenius Ulf , Bosi Ferdinando 
Published: March 2021

AbstractThe new mineral bianchiniite, Ba2(Ti4+V3+)(As2O5)2OF, has been discovered in the Monte Arsiccio mine, Apuan Alps, Tuscany, Italy. It occurs as brown {001} tabular crystals, up to 1 mm across, with a vitreous lustre. It is brittle, with a perfect {001} cleavage. Streak is brownish. In reflected light, bianchiniite is grey, with orange–yellow internal reflections. It is weakly bireflectant, with a very weak anisotropy in shades of grey. Minimum and maximum reflectance data for COM wavelengths [Rmin/Rmax(%), (λ, nm)] are: 5.0/5.8 (470), 5.7/6.5 (546), 5.7/7.0 (589) and 5.2/6.3 (650). Electron microprobe analyses gave (wt.% – average of 10 spot analyses): TiO210.34, V2O33.77, Fe2O33.76, As2O344.36, Sb2O30.22, SrO 0.45, BaO 34.79, PbO 0.28, F 1.77, sum 99.74, –O = F –0.75, total 98.99. On the basis of 12 anions per formula unit, the empirical formula of bianchiniite is (Ba2.00Sr0.04Pb0.02)Σ2.06(Ti4+1.14V3+0.44Fe3+0.42)Σ2.00[(As3.96Sb0.02)Σ3.98O10](O1.18F0.82)Σ2.00. Bianchiniite is tetragonal, space groupI4/mcm, with unit-cell parametersa= 8.7266(4),c= 15.6777(7) Å,V= 1193.91(12) Å3andZ= 8. Its crystal structure was refined from single-crystal X-ray diffraction data toR1= 0.0134 on the basis of 555 unique reflections withFo> 4σ(Fo) and 34 refined parameters. The crystal structure shows columns of corner-sharing [Ti/(V,Fe)]-centred octahedra running alongc, connected alongaandbthrough (As2O5) dimers. A {001} layer of Ba-centred [10+2]-coordinated polyhedra is intercalated between (As2O5) dimers. Bianchiniite has structural relations with fresnoite- and melilite-group minerals. The name honours the two mineral collectors Andrea Bianchini (b. 1959) and Mario Bianchini (b. 1962) for their contribution to the knowledge of the mineralogy of pyrite ± baryte ± iron-oxide ore deposits from the Apuan Alps.
Comparing de novo transcriptome assembly tools in di- and autotetraploid non-model plant species
Authors: Madritsch Silvia , Burg Agnes , Sehr Eva M. 
Published: March 2021

Abstract
Background
Polyploidy is very common in plants and can be seen as one of the key drivers in the domestication of crops and the establishment of important agronomic traits. It can be the main source of genomic repatterning and introduces gene duplications, affecting gene expression and alternative splicing. Since fully sequenced genomes are not yet available for many plant species including crops, de novo transcriptome assembly is the basis to understand molecular and functional mechanisms. However, in complex polyploid plants, de novo transcriptome assembly is challenging, leading to increased rates of fused or redundant transcripts. Since assemblers were developed mainly for diploid organisms, they may not well suited for polyploids. Also, comparative evaluations of these tools on higher polyploid plants are extremely rare. Thus, our aim was to fill this gap and to provide a basic guideline for choosing the optimal de novo assembly strategy focusing on autotetraploids, as the scientific interest in this type of polyploidy is steadily increasing.

Results
We present a comparison of two common (SOAPdenovo-Trans, Trinity) and one recently published transcriptome assembler (TransLiG) on diploid and autotetraploid species of the genera Acer and Vaccinium using Arabidopsis thaliana as a reference. The number of assembled transcripts was up to 11 and 14 times higher with an increased number of short transcripts for Acer and Vaccinium, respectively, compared to A. thaliana. In diploid samples, Trinity and TransLiG performed similarly good while in autotetraploids, TransLiG assembled most complete transcriptomes with an average of 1916 assembled BUSCOs vs. 1705 BUSCOs for Trinity. Of all three assemblers, SOAPdenovo-Trans performed worst (1133 complete BUSCOs).

Conclusion
All three assembly tools produced complete assemblies when dealing with the model organism A. thaliana, independently of its ploidy level, but their performances differed extremely when it comes to non-model autotetraploids, where specifically TransLiG and Trinity produced a high number of redundant transcripts. The recently published assembler TransLiG has not been tested yet on any plant organism but showed highest completeness and full-length transcriptomes, especially in autotetraploids. Including such species during the development and testing of new assembly tools is highly appreciated and recommended as many important crops are polyploid.
Stepwise lactate kinetics in critically ill patients: prognostic, influencing factors, and clinical phenotype
Authors: Tang Bo , Su Longxiang , Li Dongkai , Wang Ye , Liu Qianqian , Shan Guangliang , Long Yun , Liu Dawei , Zhou Xiang 
Published: March 2021

Abstract
Background
To investigate the optimal target e of lactate kinetics at different time during the resuscitation, the factors that influence whether the kinetics achieve the goals, and the clinical implications of different clinical phenotypes.

Methods
Patients with hyperlactatemia between May 1, 2013 and December 31, 2018 were retrospectively analyzed. Demographic data, basic organ function, hemodynamic parameters at ICU admission (T0) and at 6 h, 12 h, 24 h, 48 h, and 72 h, arterial blood lactate and blood glucose levels, cumulative clinical treatment conditions at different time points and final patient outcomes were collected.

Results
A total of 3298 patients were enrolled, and the mortality rate was 12.2%. The cutoff values of lactate kinetics for prognosis at 6 h, 12 h, 24 h, 48 h, and 72 h were 21%, 40%, 57%, 66%, and 72%. The APACHE II score, SOFA score, heart rate (HR), and blood glucose were risk factors that correlated with whether the lactate kinetics attained the target goal. Based on the pattens of the lactate kinetics, eight clinical phenotypes were proposed. The odds ratios of death for clinical phenotypes VIII, IV, and II were 4.39, 4.2, and 5.27-fold of those of clinical phenotype I, respectively.

Conclusion
Stepwise recovery of lactate kinetics is an important resuscitation target for patients with hyperlactatemia. The APACHE II score, SOFA score, HR, and blood glucose were independent risk factors that influenced achievement of lactate kinetic targets. The cinical phenotypes of stepwise lactate kinetics are closely related to the prognosis.
Attention-deficit/hyperactivity disorder with developmental coordination disorder: 24-year follow-up of a population-based sample
Authors: Landgren Valdemar , Fernell Elisabeth , Gillberg Christopher , Landgren Magnus , Johnson Mats 
Published: March 2021

AbstractBackgroundAlthough the body of research concerning neurodevelopmental disorders is vast, there is a scarcity of longitudinal studies beyond late adolescence, and of studies taking co-existing disorders into account. The present study aimed to investigate outcome in adulthood for children with attention-deficit/hyperactivity disorder (ADHD) combined with developmental coordination disorder (DCD) diagnosed at 6.6 years of age.MethodsOut of a screening-based population cohort of 589 individuals, 62 (10 female) diagnosed with ADHD+DCD at mean age 6.6 years naïve to stimulant treatment were followed into adulthood through national registries. Results were compared to a screen- and assessment negative population matched group from the same cohort (PM group,n = 51) and a registry-matched (RM group,n = 410) group of the same county and age.ResultsAt 30 to 31 years of age, five deaths had occurred; one in the ADHD+DCD group and two each in the comparison groups. In time to event analyses of the composite outcome of any psychiatric disorder, psychotropic prescription, sick pension or criminal sentence, events occurred at a significantly higher rate in the ADHD+DCD group (p = 0.0032, vs PM groupp = 0.0115, vs RM groupp = 0.0054). The ADHD+DCD group had significantly higher rates of psychiatric diagnoses, prescriptions of psychoactive medications and occurrence of sick pension than both comparison groups. Further, the ADHD+DCD group had significantly lower educational attainment compared to both comparison groups, more years with unemployment, and overall higher welfare recipiency. Rates of pain diagnoses and analgesic prescriptions did not separate the groups.ConclusionADHD+DCD entailed a less favorable outcome in adulthood compared to a non-clinical comparison group and a registry-matched population. Neurodevelopmental disorder diagnosed upon school entry is of prognostic utility with respect to function in adulthood, and warrants early identification and management.
Expressions of TWIST1 and CD105 markers in colorectal cancer patients and their association with metastatic potential and prognosis
Authors: Fattahi Fahimeh , Saeednejad Zanjani Leili , Vafaei Somayeh , Habibi Shams Zohreh , Kiani Jafar , Naseri Marzieh , Gheytanchi Elmira , Madjd Zahra 
Published: March 2021

Abstract
Background
TWIST1 and CD105, which contribute to tumor malignancy, are overexpressed in cancers. Accordingly, TWIST1 enhances epithelial-to-mesenchymal transition (EMT) and promotes the formation of cancer stem cells (CSCs). Also, CD105 is a neoangiogenesis marker in endothelial cells, which is introduced as a CSC marker in tumoral epithelial cells in several types of cancers. The present study was aimed to investigate expressions of TWIST1 and CD105 in colorectal cancer (CRC) patients.

Methods
Expressions of TWIST1 and CD105 in 250 CRC tissue samples were evaluated using immunohistochemistry on tissue microarrays (TMAs). In this regard, TWIST1 expression was investigated in the subcellular locations (cytoplasm and nucleus), while CD105 was mapped in endothelial cells and cytoplasmic tumor cells of CRC tissues. The association between the expression of these markers and clinicopathological parameters, as well as survival outcomes were analyzed.

Results
Results indicate a statistically significant association between higher nuclear expression levels of TWIST1 and distant metastases in CRC (P = 0.040) patients. In addition, it was shown that the increased nuclear expression of TWIST1 had a poor prognostic value for disease-specific survival (DSS) and progression-free survival (PFS) (P = 0.042, P = 0.043, respectively) in patients with CRC. Moreover, analysis of CD105 expression level has revealed that there is a statistically significant association between the increased expression of CD105 in tumoral epithelial cells and more advanced TNM stage (P = 0.050).

Conclusions
Our results demonstrate that nuclear TWIST1 and cytoplasmic CD105 expressions in tumor cells had associations with more aggressive tumor behavior and more advanced diseases in CRC cases.