bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: ANXA2 Associated Life-Threatening Coagulopathy With Hyperfibrinolysis in a Patient With Non-APL Acute Myeloid Leukemia
Authors: Ruhnke Leo , Stölzel Friedrich , Wagenführ Lisa , Altmann Heidi , Platzbecker Uwe , Herold Sylvia , Rump Andreas , Schröck Evelin , Bornhäuser Martin , Schetelig Johannes , von Bonin Malte 
Published: April 2021

Patients with acute promyelocytic leukemia (APL) often present with potentially life-threatening hemorrhagic diathesis. The underlying pathomechanisms of APL-associated coagulopathy are complex. However, two pathways considered to be APL-specific had been identified: 1) annexin A2 (ANXA2)-associated hyperfibrinolysis and 2) podoplanin (PDPN)-mediated platelet activation and aggregation. In contrast, since disseminated intravascular coagulation (DIC) is far less frequent in patients with non-APL acute myeloid leukemia (AML), the pathophysiology of AML-associated hemorrhagic disorders is not well understood. Furthermore, the potential threat of coagulopathy in non-APL AML patients may be underestimated. Herein, we report a patient with non-APL AML presenting with severe coagulopathy with hyperfibrinolysis. Since his clinical course resembled a prototypical APL-associated hemorrhagic disorder, we hypothesized pathophysiological similarities. Performing multiparametric flow cytometry (MFC) and immunofluorescence imaging (IF) studies, we found the patient’s bone-marrow mononuclear cells (BM-MNC) to express ANXA2 - a biomarker previously thought to be APL-specific. In addition, whole-exome sequencing (WES) on sorted BM-MNC (leukemia-associated immunophenotype (LAIP)1: ANXAlo, LAIP2: ANXAhi) demonstrated high intra-tumor heterogeneity. Since ANXA2 regulation is not well understood, further research to determine the coagulopathy-initiating events in AML and APL is indicated. Moreover, ANXA2 and PDPN MFC assessment as a tool to determine the risk of life-threatening DIC in AML and APL patients should be evaluated.
The Clinical and Pathological Features of Children With Microscopic Polyangiitis
Authors: Li Qian , Yu Li-Chun , Li Feng-Xia , Wang Jing , Chen Yuan , Sun Shu-Zhen 
Published: April 2021

Objective: The aim of this study was to explore the clinical features, pathological characteristics, and the prognosis of children with microscopic polyangiitis (MPA).Methods: Ten children with MPA that were hospitalized in our hospital were included in this study. The children's pre-diagnosis status, clinical manifestations, renal pathology, treatment, and prognosis data were analyzed retrospectively.Results: All 10 cases included female patients with a median age of 8.9 years old at the time of diagnosis. MPO-ANCA antibody was positive in all cases, combined with a positive anti-GBM antibody in two cases. Nine cases had primary AAV and one had antithyroid drug (ATD)-associated MPA (secondary to methimazole). Renal involvement was found in all 10 patients, lung impairment was present in eight cases, and anemia was present in nine patients. Renal biopsies were performed in all 10 patients. Segmental focal or global glomerular necrosis was observed in 70% of the patients (7/10). The treatment mainly included steroid use combined with Cyclophosphamide and Mycophenolate. The follow-up s of the patients revealed normal renal function in eight patients and progression to end-stage renal disease (ESRD) in two patients.Conclusions: Female predisposition and positive MPO-ANCA antibody were prominent in children with MPA. The patients' kidneys and lungs were the most frequently involved organs. Corticosteroid combined with immunosuppressive therapy was recommended for the treatment of MPA. Early diagnosis, prompt aggressive treatment, and regular follow-ups are also very important factors associated with a good prognosis.
Population Pharmacokinetics of Lithium in Young Pediatric Patients With Intellectual Disability
Authors: Yuan Junying , Zhang Bohao , Xu Yiran , Zhang Xiaoli , Song Juan , Zhou Wenhao , Hu Kai , Zhu Dengna , Zhang Lirong , Shao Fengmin , Zhang Shusheng , Ding Junjie , Zhu Changlian 
Published: April 2021

Background: Lithium is a well-established treatment for bipolar disorders and has been shown to be neuroprotective, and thus low doses might be useful for the treatment of childhood brain injury and neurological sequelae. However, pharmacokinetic (PK) data in children are limited. This study was to investigate the PKs after oral administration of low-dose lithium carbonate in young children with intellectual disability.Methods: Fifty-two children with intellectual disability aged 4–10 years old were enrolled. A series of blood samples were collected after a single-dose administration of lithium carbonate. The serum lithium concentration was measured using a validated ion chromatography assay, and the PK concentration data were modeled using a nonlinear mixed effect model in the NONMEM program.Results: The lithium concentration over time was adequately described by a two-compartment disposition, with a transient absorption and first-order elimination process. The inclusion of body weight as an allometric factor significantly improved the model fit, but age and gender were not associated with the PKs of lithium. The clearance, central volume, inter-compartmental clearance, and peripheral volume estimates from the final population PK model were 0.98 L/h, 13.1 L, 0.84 L/h, and 8.2 L for children with a body weight of 20 kg. The model evaluation suggested that there is no obvious discrepancy between the observations and predictions in the proposed model. A visual predictive check demonstrated the good predictive performance of the final model.Conclusions: The lithium PK properties in young children were similar to those in older children and adults. The proposed model can be used for further PK/PD analysis to optimize the dosage regimen of lithium in children.
Depression and Anxiety in Patients With Cancer: A Cross-Sectional Study
Authors: Naser Abdallah Y. , Hameed Anas Nawfal , Mustafa Nour , Alwafi Hassan , Dahmash Eman Zmaily , Alyami Hamad S. , Khalil Haya 
Published: April 2021

ObjectivesDepression and anxiety persist in cancer patients, creating an additional burden during treatment and making it more challenging in terms of management and control. Studies on the prevalence of depression and anxiety among cancer patients in the Middle East are limited and include many limitations such as their small sample sizes and restriction to a specific type of cancer in specific clinical settings. This study aimed to describe the prevalence and risk factors of depression and anxiety among cancer patients in the inpatient and outpatient settings.Materials and MethodsA total of 1,011 patients (399 inpatients and 612 outpatients) formed the study sample. Patients’ psychological status was assessed using the Hospital Anxiety and Depression Scale (HADS), the Patient Health Questionnaire (PHQ-9), and the Generalized Anxiety Disorder 7-item (GAD-7) scale. The prevalence rate of depressive and anxious symptomatology was estimated by dividing the number of patients who exceeded the borderline score: 10 or more for each subscale of the HADS scale, 15 or more for the GAD-7 scale, and 15 or more in the PHQ-9 by the total number of the patients. Risk factors were identified using logistic regression.ResultsThe prevalence of depressive and anxious symptomatology among all patients was 23.4% and 19.1–19.9%, respectively. Depressive symptomatology was more prevalent across patients who were hospitalized (37.1%) compared with patients in the outpatient setting (14.5%) (p &lt; 0.001). Similarly, anxious symptomatology was more prevalent in the inpatient setting (p &lt; 0.001). In the inpatient setting, depressive symptomatology was more prevalent among patients with bladder cancer, while severe anxious symptomatology was more prevalent across patients with lung cancer. In the outpatient setting, depressive and anxious symptomatology was more prevalent among breast and prostate cancer patients, respectively. Despite that, around 42.7% and 24.8% of the patients, respectively, reported that they feel anxious and depressed, and only 15.5% of them were using medications to manage their conditions.ConclusionOur study findings demonstrated a higher prevalence of depressive and anxious symptomatology in the inpatient setting and advanced disease stages. In addition, the underutilization of antidepressant therapy was observed. There is a need to consider mental disorders as part of the treatment protocol for cancer patients. Enhanced clinical monitoring and treatment of depression and anxiety of cancer patients are required.
Adverse Psychological Reactions and Psychological Aids for Medical Staff During the COVID-19 Outbreak in China
Authors: Su Qinji , Ma Xiaoyun , Liu Shun , Liu Shaogang , Goodman Bernard A. , Yu Miaoyu , Guo Wenbin 
Published: April 2021

Background: The outbreak of the novel coronavirus disease COVID-19 caused panic and psychological stress throughout the World. We investigated the extent of adverse psychological reactions in two medical staff groups in China, and explored the importance of online psychological assistance for them.Methods: A cross-sectional online survey including Hospital Anxiety and Depression Scale (HADS) and Insomnia Severity Index (ISI) was utilized to assess anxiety, depression, and insomnia. Propensity score matching (PSM) was applied to match sex and age between the two groups. Differences in the prevalence of adverse psychological reactions between the two groups were compared by a Chi-square test. A multivariate logistic regression analysis was utilized to search for associated adverse psychological reaction factors of two groups.Results: A total of 2,920 medical staff took part in the survey, including 470 frontline and 2,450 non-frontline medical staff. The risk of the frontline group experiencing anxiety, depression, insomnia-early, insomnia-middle, and insomnia-late were 1.16, 1.28, 1.26, 1.22, 1.28 times those of the non-frontline group after PSM. For frontline medical staff, the spinsterhood state (OR = 1.23, 95% CI: 1.00–1.51; P = 0.05) was a risk factor for anxiety. Bachelor or college degree (OR = 2.23, 95% CI: 1.24–4.02, P = 0.01) and a contact history with COVID-19 patients (OR = 1.62, 95% CI: 1.10–2.40; P = 0.02) were risk factors for insomnia. For non-frontline medical staff, being a woman (OR = 1.49, 95% CI: 1.08–2.06, P = 0.01) was a risk factor for anxiety, whilst being in a middle age group was a protective factor for anxiety (OR = 0.70, 95% CI: 0.50–0.99, P = 0.04) and depression (OR = 0.65, 95% CI: 0.45–0.93, P = 0.02). Being a woman (OR = 1.47, 95% CI: 1.14–1.89, P = 0.003) and working in a COVID-19 unit (OR = 1.31, 95% CI: 1.11–1.54, P = 0.001) were risk factors for insomnia, whilst the spinsterhood state (OR = 0.80, 95% CI: 0.67–0.95; P = 0.01) was a protective factor for insomnia. Online forms of psychological aid were all popular with medical staff.Conclusions: The prevalence of anxiety, depression, and insomnia in frontline medical staff was significantly higher than in the non-frontline group. Appropriate intervention methods should be adopted according to the different influencing factors of the two groups. Online psychological aid was the preferred mechanism for relieving psychological problems.
Negative Appraisals of the COVID-19 Social Impact Associated With the Improvement of Depression and Anxiety in Patients After COVID-19 Recovery
Authors: Chen Wentao , Ju Yumeng , Liu Bangshan , Huang Mei , Yang Aiping , Zhou Yun , Wang Mi , Liao Mei , Shu Kongliang , Liu Jiyang , Zhang Yan 
Published: April 2021

Objective: Little is known about the factors affecting the recovery of mental health in COVID-19 patients. The purpose of this study is to look into the change of psychological distress and to explore the role of negative appraisals in the improvement of psychological distress in COVID-19 patients after they recovered from the infection.Methods: We conducted a longitudinal survey on patients with COVID-19 infection in Changsha. The 9-item Patient Health scale, the 7-item Generalized Anxiety Disorder scale, and a newly developed measure, the COVID-19 Impact Scale (CIS) were applied to assess patients' depression, anxiety, and negative appraisal toward COVID-19 infection during their hospitalization and 1 month post-discharge.Results: Seventy-two patients were included in the analysis. A significant decrease in anxiety and depression levels was observed after patients were discharged from hospital. Two meaningful factors of the CIS were extracted based on factor analysis, namely “health impact,” and “social impact.” The change of social impact explained the 12.7 and 10.5% variance in the depression and anxiety symptom improvement, respectively.Conclusions: Change in negative appraisals, especially the appraisals related to COVID-19 social impact may play a vital role in the relief of psychological distress of infected patients. Therefore, a cognitive and social care perspective might be considered when promoting the mental health recovery and readjustment to society among COVID-19 patients.
Autism-Associated Variant in the SLC6A3 Gene Alters the Oral Microbiome and Metabolism in a Murine Model
Authors: DiCarlo Gabriella E. , Mabry Samuel J. , Cao Xixi , McMillan Clara , Woynaroski Tiffany G. , Harrison Fiona E. , Reddy India A. , Matthies Heinrich J. G. , Flynn Charles R. , Wallace Mark T. , Wu Hui , Galli Aurelio 
Published: April 2021

Background: Altered dopamine (DA) signaling has been associated with autism spectrum disorder (ASD), a neurodevelopmental condition estimated to impact 1 in 54 children in the United States. There is growing evidence for alterations in both gastrointestinal function and oral microbiome composition in ASD. Recent work suggests that rare variants of the SLC6A3 gene encoding the DA transporter (DAT) identified in individuals with ASD result in structural and functional changes to the DAT. One such recently identified de novo mutation is a threonine to methionine substitution at position 356 of the DAT (DAT T356M). The DAT T356M variant is associated with ASD-like phenotypes in mice homozygous for the mutation (DAT T356M+/+), including social deficits, hyperactivity, and impaired DA signaling. Here, we determine the impact of this altered DA signaling as it relates to altered oral microbiota, and metabolic and gastrointestinal dysfunction.Methods: In the DAT T356M+/+ mouse, we determine the oral microbiota composition, metabolic function, and gastrointestinal (GI) function. We examined oral microbiota by 16S RNA sequencing. We measured metabolic function by examining glucose tolerance and we probed gastrointestinal parameters by measuring fecal dimensions and weight.Results: In the DAT T356M+/+ mouse, we evaluate how altered DA signaling relates to metabolic dysfunction and altered oral microbiota. We demonstrate that male DAT T356M+/+ mice weigh less (Wild type (WT) = 26.48 ± 0.6405 g, DAT T356M+/+ = 24.14 ± 0.4083 g) and have decreased body fat (WT = 14.89 ± 0.6206%, DAT T356M+/+ = 12.72 ± 0.4160%). These mice display improved glucose handling (WT = 32.60 ± 0.3298 kcal/g, DAT T356M+/+ = 36.97 ± 0.4910 kcal/g), and an altered oral microbiota. We found a significant decrease in Fusobacterium abundance. The abundance of Fusobacterium was associated with improved glucose handling and decreased body fat.Conclusions: Our findings provide new insights into how DAT dysfunction may alter gastrointestinal function, composition of the oral microbiota, and metabolism. Our data suggest that impaired DA signaling in ASD is associated with a number of metabolic and gastrointestinal changes which are common in individuals with ASD.
Entrepreneurial Pathways in Art
Authors: Tuominiemi Kaisu , Benzenberg Scott 
Published: April 2021

Art programs at the university level are often designed in a studio-based model where the curriculum objective is “high-levels of disciplinary expertise” (Hong, Essig, & Bridgstock, 2012). These programs graduate artists who, while highly proficient in creation and performance, must navigate a career market which is limited and highly competitive. This studio model is shifting. Many arts programs at the university level are now beginning to incorporate courses which help artists as they navigate the business of the art world, but these types of interventions still neglect opportunities to fully harness artistic skillsets of art students.
Arts Entrepreneurship is an emerging discipline in post-secondary education. This discipline aims address the needs of the artist while also recognizing the unique habits of mind the artist might bring into enterprise. The scope of this discipline extends beyond studio practices by considering and measuring the impact of an artists’ work. “The unique mission of arts programs and therefore a unique of arts entrepreneurship education and a defining aspect of its signature pedagogy is the practice of making art work in and for the real world” (Hong, Essig, & Bridgstock, 2012). In this discipline, artists extend the scope of their “work” beyond creation and towards practices which can future sustain an artistic venture. Arts Entrepreneurship therefore seeks to graduate artists who are able to consider and measure the scope of external impacts.
The proposal here seeks to address the need of graduates in art education to pursue meaningful employment while also generating new potentials the artist’s role in wider society.
Medidas Alternativas de Inflación
Authors: Mateos Calixto , Gaytán Alejandro 
Published: April 2021

El crecimiento del índice de precios al consumidor es el indicador más utilizado para medir la inflación. Sin embargo, dicho indicador puede reflejar variaciones en precios relativos o algunas otras perturbaciones cuyo origen radique en consideraciones ajenas a la política monetaria.	En este documento se reseñan y se aplican al caso de México las metodologías para calcular una serie de medidas que han sido desarrolladas con el objetivo de depurar al índice de precios al consumidor de las variaciones temporales o de precios relativos de manera que el indicador así obtenido sea una medida de inflación que capture únicamente el crecimiento sostenido en el nivel general de precios. Cada una de estas medidas provee información sobre algún aspecto del proceso inflacionario, por lo que resulta importante que el seguimiento de estas medidas se incorpore dentro del análisis de la inflación en México.
PEMANFAATAN TANAMAN LIDAH MERTUA (SANSEVIERA SP) UNTUK MENURUNKAN GAS NOx DI DALAM RUANGAN
Authors: Ramadhan Rangga Dian , - Khambali , Sari Ernita - 
Published: April 2021

Nitrogen oksida (NOx) adalah gas yang di hasilkan oleh kendaraan bermotor yang menjadi salah satu penyebab polusi udara. Berdasarkan data dari DLH Kota Surabaya kadar NOx dari tahun 2017 ke tahun 2018 meningkat dari 10,68 µg/m3 hingga 15,10 µg/m3. Gas NOx yang terhirup melalui pernafasan menyebabkan asma hingga bronchitis. Tanaman yang memiliki kemampuan meyerap polutan pencemaran udara adalah Lidah mertua (Sanseviera Sp). Tujuan penelitian ini adalah untuk mengetahui pengaruh tanaman lidah mertua terhadap penurunan kadar gas NOx di dalam ruangan.Jenis penelitian ini adalah Pre-experimental design dengan desain penelitian One group pretest-postest design. Variabel terikat pada penelitian ini adalah NOx dengan variabel bebas tanaman lidah mertua yang berjumlah 16 helai dan 16 kali replikasi. Analisis data yang di gunakan dalam penelitian ini menggunakan uji normalitas Shapiro-wilk dan kemudian di uji menggunakan Paired T-test yang berfungsi untuk mengetahui perbedaan sebelum dan sesudah dilakukan perlakuan pada sampel.Hasil penelitian menunjukkan bahwa rata-rata gas NOx sebelum dilakukan perlakuan sebesar 23,56ppm, dan setelah perlakuan sebesar 14ppm dengan presentase penurunan 40,58%. Hasil uji statistik mendapatkan nilai P0,05 yang berarti ada penurunan yang signifikan terhadap gas NOx pada udara ruangan dengan tanaman lidah mertua.Tanaman lidah mertua dapat menurunkan kadar NOx pada emisi gas buang kendaraan bermotor. Bagi peneliti lain dapat menambahkan waktu kontak yang bervariasi agar hasil penyerapan dapat ditentukan yang paling efektif. Disarankan kepada masyarakat untuk melakukan pengurangan pencemaran udara dapat memanfaatkan tanaman lidah mertua untuk menyerap gas NOx.
Hubungan Kondisi Fisik Rumah dan Tingkat Ekonomi Orangtua Terhadap Kejadian Pneumonia Pada Balita (Studi Kasus di Wilayah Kerja Puskesmas Sukodono))
Authors: Ramadhani Diaz , - Nurhaidah , - Narwati 
Published: April 2021

Pneumonia pada balita masih menjadi salah satu penyebab kematian tertinggi di dunia. Kematian karena pneumonia pada masa kanak-kanak sangat terkait dengan faktor yang berhubungan dengan kemiskinan seperti kurang gizi, polusi udara dalam ruangan, dan akses yang tidak memadai ke perawatan kesehatan. Tujuan penelitian ini untuk mengetahui hubungan antara kondisi fisik rumah dan tingkat ekonomi orangtua dengan kejadian pneumonia pada balita di wilayah kerja Puskesmas Sukodono.Penelitian ini merupakan penelitian observasional analitik menggunakan studi Case Control. Sebanyak 25 rumah balita menderita pneumonia sebagai kasus dan 25 rumah balita tidak menderita pneumonia sebagai kontrol. Responden penelitian ini adalah ibu balita kelompok kasus maupun kontrol. Data yang diperoleh dianalisis secara univariat dan bivariat dengan uji Chi Square.Hasil analisis menunjukkan dari lima variabel yang diteliti, dua variabel memiliki hubungan bermakna dengan kejadian pneumonia pada balita, yaitu kepadatan kamar tidur (p = 0,027) dan kelembaban rumah (p = 0,030), sedangkan variabel pencahayaan alami (p = 0,172), suhu rumah (0,382), dan tingkat ekonomi orangtua (p = 0,349) tidak memiliki hubungan dengan kejadian pneumonia pada balita.Kesimpulan penelitian ini yaitu ada hubungan antara kepadatan kamar tidur dan kelembaban rumah dengan kejadian pneumonia pada balita, sedangkan suhu rumah, pencahayaan alami, dan tingkat ekonomi orangtua tidak memiliki hubungan dengan kejadian pneumonia pada balita. Saran bagi masyarakat untuk ikut berperan dalam mencegah penularan penyakit pneumonia dengan rajin membuka jendela rumah tiap hari dan kamar tidur maksimal dihuni oleh 2 orang dewasa dan 1 balita. Saran bagi puskesmas untuk meningkatkan pengetahuan pneumonia pada ibu dengan penyuluhan dan pembinaan sanitasi rumah.
CRITICISM STRATEGY BY MAHFUD MD IN INDONESIA LAWYERS CLUB
Authors: Manurung Lastri Wahyuni 
Published: April 2021

AbstrakKritik, di satu sisi digunakan untuk mengendalikan dan mengarahkan seseorang dari kesalahan dengan menggunakan kata-kata verbal. Di sisi lain, kritik adalah tindakan linguistik yang mungkin dapat menyebabkan konflik dan kecenderungan mengancam muka seseorang. ‘Muka’ meliputi keinginan agar citra diri ini dihargai dan disetujui oleh lawan bicara. Penelitian ini dilakukan untuk mengetahui, strategi kritik Mahfud MD ketika memberikan kritik. Ditemukan bahwa apa pun kritik yang diberikan oleh Mahfud MD, ia melakukannya dengan memberikan koreksi.AbstractCriticism, in one hand was used as to control and to direct someone from mistake by using verbal words. On the other hand, critics were a linguistic action that possibly caused conflict and tendency to threat someone’s face. It was the face that crucially including the desire that this self-image be appreciated and approved by interlocutors. This research was conducted to find out, the criticism strategy of Mahfud MD in giving critics. It was found that whatever the critics that Mahfud MD gives, he must accomplish it by giving correction