bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, Spectral Investigations, Biological Potential and Molecular
Docking Study of Novel Schiff Base and its Transition Metal Complexes
Authors: Kumar Manoj , Aggarwal Pallvi , Varol Mehmet , Sharma Shashi , Rani Anita , Abbas Zahoor , Prakash Vinit , Tuli Hardeep Singh 
Published: November 2021

Aim:
The present study was designed to synthesize novel Schiff bases and their metal
complexes with promising antimicrobial and anti-angiogenic potential.

Background:
Currently, drug resistance has been seen in a diverse range of microbes, which is considered
a major threat to widespread infectious diseases. Therefore, it is essential to investigate novel
therapeutic molecules with broad-spectrum activities.

Method:
The novel Schiff base ligands were synthesized by using a condensation reaction of
ethylenediamine with p-chloroacetanilide and p-bromoactanilide. Fe(III), Ni(II), Mn(II), and Co(II)
metal complexes were prepared by refluxing the ligand with respective metal chloride salts in a 2:1
molar ratio.

Results:
Structures of the synthesized compounds were characterized by IR, 1H NMR, UV-VIS,
and mass spectrometry. Anti-microbial activities of all the synthesized compounds were determined
against bacterial strains (S. aureus and K. pneumoniae) and fungal strains (A. niger and Trichophyton
rubrum) by using the well plate diffusion method. DNA photo-cleavage and anti-angiogenic
properties were evaluated by gel electrophoresis and CAM assay, respectively. Molecular
docking studies were performed to analyze the binding interactions of synthesized compounds with
topoisomerase II alpha.

Conclusion:
The present preliminary efforts may be helpful to design novel drugs with therapeutic
potential.
eHealth Interventions for Treatment and Prevention of Depression, Anxiety, and Insomnia During Pregnancy: Systematic Review and Meta-analysis
Authors: Silang Katherine A , Sohal Pooja R , Bright Katherine S , Leason Jennifer , Roos Leslie , Lebel Catherine , Giesbrecht Gerald F , Tomfohr-Madsen Lianne M 
Published: November 2021

Background
Pregnancy is associated with an increased risk for depression, anxiety, and insomnia. eHealth interventions provide a promising and accessible treatment alternative to face-to-face interventions.

Objective
The objective of this systematic review and meta-analysis is to determine the effectiveness of eHealth interventions in preventing and treating depression, anxiety, and insomnia during pregnancy. Secondary aims are to identify demographic and intervention moderators of effectiveness.

Methods
A total of 5 databases (PsycINFO, Medline, CINAHL, Embase, and Cochrane) were searched from inception to May 2021. Terms related to eHealth, pregnancy, randomized controlled trials (RCTs), depression, anxiety, and insomnia were included. RCTs and pilot RCTs were included if they reported an eHealth intervention for the prevention or treatment of depression, anxiety, or insomnia in pregnant women. Study screening, data extractions, and quality assessment were conducted independently by 2 reviewers from an 8-member research team (KAS, PRS, Hangsel Sanguino, Roshni Sohail, Jasleen Kaur, Songyang (Mark) Jin, Makayla Freeman, and Beatrice Valmana). Random-effects meta-analyses of pooled effect sizes were conducted to determine the effect of eHealth interventions on prenatal mental health. Meta-regression analyses were conducted to identify potential moderators.

Results
In total, 17 studies were included in this review that assessed changes in depression (11/17, 65%), anxiety (10/17, 59%), and insomnia (3/17, 18%). Several studies included both depression and anxiety symptoms as outcomes (7/17, 41%). The results indicated that during pregnancy, eHealth interventions showed small effect sizes for preventing and treating symptoms of anxiety and depression and a moderate effect size for treating symptoms of insomnia. With the exception of intervention type for the outcome of depressive symptoms, where mindfulness interventions outperformed other intervention types, no significant moderators were detected.

Conclusions
eHealth interventions are an accessible and promising resource for treating symptoms of anxiety, depression, and insomnia during pregnancy. However, more research is necessary to identify ways to increase the efficacy of eHealth interventions for this population.

Trial Registration
PROSPERO (International Prospective Register of Systematic Reviews) CRD42020205954; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=205954
Efektivitas Metode Field Trip Dengan Aplikasi PlantNet Pada Materi Spermatophyta Sebagai Alternatif Inovasi Pembelajaran
Authors: Muchsin Adnan , Nurfadilah Zakia , Riandi Riandi , Supriatno Bambang 
Published: November 2021

Learning system during a pandemic requires everything to be done online. This is a challenge for teachers to continue applying certain learning methods without eliminating the essence and purpose of the method. The innovation of the field trip method with technology application is expected to be an alternative of learning. Thus, this study aims to analyze the effectiveness of using the PlantNet Application on identifying and classifying of Spermatophyte Plants. This study used a qualitative descriptive method and the subjects of this research are high school students of grade X. The analyzed aspects in this research are learning outcomes, PlantNet use and user responses. The results of this study indicate that 88% of students achieve good result and this can be stated as a successful learning innovation based on individual completeness. Regarding the use of PlantNet, almost all of the indicators received very good ratings by students. For user responses, teachers and students have a good to very good response to the use of the PlantNet application.
Abstrak. Pembelajaran di masa pandemi mengharuskan segala sesuatu dilakukan secara daring. Hal ini menjadi tantangan bagi guru untuk tetap menerapkan metode pembelajaran tertentu tanpa harus menghilangkan esensi dan tujuan dari metode tersebut. Inovasi metode field trip dengan bantuan aplikasi diharapkan menjadi sebuah alternatif pembelajaran. Sehingga, penelitian ini bertujuan untuk menganalisis efektivitas penggunaan aplikasi PlantNet pada materi identifikasi dan klasifikasi Spermatophyta. Penelitian ini menggunakan metode deskriptif kualitatif dengan subjek penelitian Siswa SMA Kelas X. Aspek-aspek yang dianalisis yaitu hasil belajar, fungsi PlantNet dan respon pengguna. Hasil penelitian ini menunjukkan 88% siswa mencapai ketuntasan belajar atau lebih dari ketuntasan individu 85%, sehingga pembelajaran dikatakan berhasil. Terkait fungsi PlantNet, hampir semua indikator fungsi memperoleh penilaian yang sangat baik oleh siswa. Untuk respon pengguna, guru dan siswa memiliki respon yang baik hingga sangat baik terhadap penggunaan aplikasi PlantNet.
EFEK INDOOR AIR POLLUTION TERHADAP KESEHATAN
Authors: Aurora Wahyu Indah Dewi 
Published: November 2021

ABSTRACT
In recent decades, indoor air quality has been of particular concern because of its contribution to health. It is estimated that as much as 90% of people spend their time indoors rather than outdoors. If the ventilation system is poor, it will result in an accumulation of pollutants in the room. These pollutants can come from outdoor air that enters the room, growing microorganisms, interior furniture or furniture or from the daily activities of humans themselves. The health problems that will be caused also vary. It can be from lung disease caused by inhalation of dangerous pollutants such as lung infections, pneumonia, asthma or COPD. Or other diseases such as Sick Building Syndrome, nasopharyngeal cancer, skin irritation, eye irritation, etc. To overcome this, careful planning is needed when building a room or building to minimize health problems due to indoor air, one of which is collaborating with several experts.
Keywords: Indoor Air Quality, Indoor Air Pollution, Health disease
ABSTRAK
Dalam beberapa decade terakhir,kualitas udara dalam ruangan menjadi perhatian khusus karena kontribusinya pada segi kesehatan. Diperkirakan ada sebanyak 90% orang-orang menghabiskan waktunya di dalam ruangan daripada di luar ruangan. Jika system ventilasi buruk, maka akan menghasilkan akumulasi polutan yang ada dalam ruangan. Polutan tersebut bisa berasal dari udara luar ruangan yang masuk ke dalam ruangan, mikroorganise yang tumbuh, perabotan atau furniture interior ruangan ataupun dari aktivitas keseharian manusia itu sendiri. Gangguan kesehatan yang akan diakibatkan pun bermacam-macam. Bisa dari penyakit paru akibat terhirup polutan yang berbahaya seperti penyakit infeksi paru, pneumonia, asma atau PPOK. Atau penyakit lain seperti Sick Building Syndrome, kanker nasofaring, iritasi kulit, iritasi pada mata, dll. Untuk mengatasinya perlulah perencanaan yang matang pada saat pembangunan sebuah ruangan atau gedung untuk meminimalisir gangguan kesehatan akibat udara dalam ruangan, salah satunya adalah berkolaborasi dengan beberapa ahli.
Keywords: Indoor Air Quality, Indoor Air Pollution, Health disease
PENGETAHUAN DAN SIKAP TENTANG TANDA BAHAYA KEHAMILAN BERHUBUNGAN DENGAN PEMANFAATAN BUKU KIA
Authors: Dewie Artika 
Published: November 2021

Background : The Maternal and Child Health (MCH) Handbook contains complete information, including early detection or danger signs of maternal health problems from pregnancy to childbirth to increase knowledge of mothers and their families. The attitude of pregnant women about signs of pregnancy is important in changing the behavior of pregnant women in dealing with signs of pregnancy.
Objective : To determine the relationship between knowledge and attitudes of pregnant women about the danger signs of pregnancy with the use of the MCH Handbook.
Method : Using a cross-sectional design. The population used was trimester III pregnant women who had MCH books and were visiting to carry out pregnancy checks at Puskesmas Kota Palu (11 Puskesmas) during the research period in 2019. Using the cluster sampling method with a total of 110 respondents. Primary data were collected through ODK Collect, then analyzed univariate and bivariate.
Results : There is a relationship between knowledge about the danger signs of pregnancy and the use of the MCH Handbook (p-value = 0.003). There is a relationship between the attitudes of pregnant women about danger signs and the use of the MCH Handbook (p-value = 0.008). OR = 3,235 indicates that mothers with positive attitudes are 3,235 times more likely to use the MCH handbook than mothers who are negative.
Conclusion : There is a relationship between knowledge and attitudes about the danger signs of pregnancy and the use of the MCH Handbook.
Keywords: Knowledge, Attitudes, danger sign of pregnancy, MCH Handbook.
WORKSHOP ECO-BATIK BERBASIS KONSERVASI LOCAL WISDOM BAGI GURU-GURU PAUD/TK DI KOTA JAMBI SEBAGAI UPAYA REVITALISASI BUDAYA BATIK JAMBI
Authors: Susanti Nova , Muazzomi Nyimas , Indryani Indryani , Sanova Aulia 
Published: November 2021

Batik merupakan salah satu warisan budaya leluhur Indonesia yang harus dipertahankan karena memiliki karakter unsur budaya berbasis local wisdom yang sarat akan nilai-nilai sosial dan spiritual suatu daerah. Pada dahulu kala teknik pengerjaan batik masih bersifat sangat tradisional dengan menggunakan motif lukis dan pewarna alam. Salah satu cara menjaga kelestarian keeksistensian batik agar tidak punah tergerus oleh zaman modernisasi adalah dengan melalui media pendidikan dengan cara memperkenalkan dan memasyarakatkan batik kepada generasi emas sejak dini, sehingga perlu dihidupkan kembali kegiatan membelajarkan budaya membatik. Hal ini bisa diawali dengan dengan memberikan sebentuk pelatihan dan pendampingan bagi guru-guru PAUD yang ada di Kota Jambi. Capaian soft skill dari hasil kegaitan ini adalah terciptanya suatu kreativitas peserta dalam melukis dan memadukan warna batik, memunculkan kecakapan hidup (life skill) dalam seni perbatikan, sikap kesadaran peduli dan cinta lingkungan, menambah pengalaman yang berwawasan lingkungan (social experience) dan tentunya tercipta nya sebuah karya hasil karya para peserta berupa produk batik yang ramah lingkungan karena menggunakan pewarna alam. Sementara untuk capaian jangka panjang berupa publikasi jurnal dan bahan ajar cetak modul tentang Eco-Batik. Karya produk yang dihasilkan berupa batik tulis dengan motif flora dan fauna sesuai tema karakteristik anak TK/PAUD yang ramah lingkungan (Eco-Batik). Pada proses pewarnaannya menggunakan pewarna alam yang berasal dari ekstrak kulit jengkol, buah naga, daun inay, daun suji dan kunyit. Begitu juga pada proses penguncian warna (fiksasi), agar warna kain terlihat tua maka ditambahkan serbuk gambir, air kapur dan tunjung.
ANALISIS FAKTOR RISIKO TERJADINYA DIARE PADA BALITA DI WILAYAH KERJA PUSKESMAS PAKUAN BARU KOTA JAMBI
Authors: Fitriani Nurul , Darmawan Armaidi , Puspasari Anggelia 
Published: November 2021

ABSTRACT :
Diarrheal is one of the main causes of the high morbidity and mortality rates for children worldwide. Identified risk factor of diarrhea provide better prevention and treatment strategy. The aims of this study was to determine the description and relationship of risk factors for exclusive breastfeeding, immunization status, age in children, gender in children, mother’s hand washing habits, water sources, family latrines, mother’s education level, mother’s employment status, socioeconomic with the incidence of diarrhea in children under two in the Pakuan Baru Community Health Center Jambi City in 2020. The study design was case-control. This research held in Pakuan Baru Community Health Center Located in Jambi. This research periods was August-November 2020. One hundred of under two children participated in this study, 50 suffering diarrhea and 50 not suffering diarrhea. Interview with questioner was perform to asses risk factor of diarrhea. This study reported age 0-12 months, not having exclusive breast feeding, not having complete immunization, unproper hand washing technique, unproper water resources, low education level of mothers and low socio-economic increased risk of diarrhea in children under two. Dominant factor for risk of diarrhea were unproper hand washing technique and incomplete immunization.
Keywords : Diarrhea, risk factors, toddler

Abstrak:
Penyakit diare merupakan salah satu penyebab utama tingginya angka kesakitan dan kematian anak di dunia. Identifikasi faktor risiko diare selaras dengan strategi pencegajan dan tatalaksana diare yang lebih menyeluruh. Tujuan penelitian ini untuk mengetahui gambaran dan hubungan faktor resiko ASI eksklusif, status imunisasi, usia pada anak, jenis kelamin pada anak, kebiasaan mencuci tangan pada ibu, sumber air, jamban keluarga, tingkat pendidikan ibu, status pekerjaan ibu, sosial ekonomi dengan kejadian diare pada balita di Wilayah Puskesmas Pakuan Baru Kota Jambi Tahun 2020. Penelitian merupakan penelitian kasus kontrol. Peneltian berlangsung di wilayah Puskesmas Pakuan Baru Kota Jambi, selama Agustus-November 2020. Sebanyak 100 balita dibawah dua tahun mengikuti penelitian ini, 50 orang merupakan balita diare dan 50 orang tidak menderita diare. Wawancara dengan ibu berdasarkan kuesioner dilakukan untuk pengambilan data risiko diare. Studi ini melaporkan menunjukkan balita usia 0-12 bulan, tidak mendapatkan ASI eksklusif, imunisasi yang tidak lengkap, kebiasaan mencuci tangan yang buruk, sumber air yang buruk, rendahnya tingkat pendidikan ibu dan sosial ekonomi yang rendah meningkatkan risiko balita mengalami diare. Faktor risiko paling dominan dari analisis multivariate adalah kebiasaan mencuci tangan yang buruk dan imunisasi yang tidak lengkap.
Kata Kunci : Diare , faktor resiko, balita
Penerapan Prinsip Self Determination terhadap Pembentukan Negara Kosovo Ditinjau dari Perspektif Hukum Internasional
Authors: Dwi Saputra Yogi , Ramlan Ramlan 
Published: November 2021

Negara adalah lanjutan dari kehendak manusia bergaul antara seorang dengan orang lainnya dalam rangka menyempurnakan segala kebutuhan hidupnya. Semakin luasnya pergaulan manusia tadi maka semakin banyak kebutuhannya, maka bertambah besar kebutuhannya kepada negara yang akan melindungi dan memelihara hidupnya. Pada tanggal 17 Februari 2008, parlemen Kosovo memproklamasikan Kosovo sebagai negara merdeka, yang lepas dari Serbia pada sidang parlemen yang dihadiri 109 anggota. Sebelumnya Kosovo adalah satu provinsi dibawah kekuasaan Serbia yang mayoritas beretnis Albania. Tujuan penelitian ini dimaksudkan untuk mengetahui bagaimana pengaturan hukum internasional mengenai pembentukan negara dengan menggunakan hak menentukan nasib sendiri dan apa arti penting pengakuan dalam pembentukan suatu negara. Metode Penelitian yang digunakan adalah tipe penilitian yuridis normatif. Hasil penelitian menunjukkan pada saat ini, Hukum Internasional telah mengakui hak untuk menentukan nasib sendiri sebagai salah satu Hak Asasi Manusia dan berdasarkan hak ini semua bangsa bebas untuk menentukan status politik dan mengejar pembangunan ekonomi, sosial dan budaya. Namun, dalam konteks hukum internasional kemerdekaan sebagai wujud dari hak untuk menentukan nasib sendiri dimaksudkan untuk membebaskan diri dari penjajahan dan dominasi/kekuasaan asing. Dalam masalah pengakuan, unsur-unsur politik dan hukum sulit untuk dipisahkan secara jelas karena pemberian dan penolakan pengakuan oleh suatu negara sering dipengaruhi pertimbangan politik, sedangkan akibatnya mempunyai ikatan hukum. Definisi atau unsur-unsur negara terdapat dalam Konvensi Montevideo 1933 (Montevideo The Convention on Rights and Duties of State of 1933), dimana pengakuan merupakan unsur deklaratif dan apabila semua unsur konstitutif telah dipenuhi oleh masyarakat politik, maka dengan sendirinya ia telah merupakan sebuah Negara dan harus diperlakukan secara demikian oleh Negara-negara lainya.
Characteristics of Workplace Psychosocial Resources and Risk of Diabetes: A Prospective Cohort Study
Authors: Xu Tianwei , Clark Alice J. , Pentti Jaana , Rugulies Reiner , Lange Theis , Vahtera Jussi , Magnusson Hanson Linda L. , Westerlund Hugo , Kivimäki Mika , Rod Naja H. 
Published: November 2021

OBJECTIVE
To examine whether characteristics of workplace psychosocial resources are associated with the risk of type 2 diabetes among employees.

RESEARCH DESIGN AND METHODS
Participants were 49,835 employees (77% women, aged 40–65 years, and diabetes free at baseline) from the Finnish Public Sector cohort study. Characteristics of horizontal (culture of collaboration and support from colleagues) and vertical (leadership quality and organizational procedural justice) psychosocial resources were self-reported. Incident type 2 diabetes (n = 2,148) was ascertained through linkage to electronic health records from national registers. We used latent class modeling to assess the clustering of resource characteristics. Cox proportional hazards models were used to examine the relationship between the identified clusters and risk of type 2 diabetes during 10.9 years of follow-up, adjusting for age, sex, marital status, educational level, type of employment contract, comorbidity, and diagnosed mental disorders.

RESULTS
We identified four patterns of workplace psychosocial resources: unfavorable, favorable vertical, favorable horizontal, and favorable vertical and horizontal. Compared with unfavorable, favorable vertical (hazard ratio 0.87 [95% CI 0.78; 0.97]), favorable horizontal (0.77 [0.67; 0.88]), and favorable vertical and horizontal (0.77 [0.68; 0.86]) resources were associated with a lower risk of type 2 diabetes, with the strongest associations seen in employees at age ≥55 years (Pinteraction = 0.03). These associations were robust to multivariable adjustments and were not explained by reverse causation.

CONCLUSIONS
A favorable culture of collaboration, support from colleagues, leadership quality, and organizational procedural justice are associated with a lower risk of employees developing type 2 diabetes than in those without such favorable workplace psychosocial resources.
The significance of homocysteine in patients with hypertension
Authors: Gluszek Jerzy , Kosicka Teresa 
Published: November 2021

Abstract
Cardiovascular disease is the most common cause of death in developed countries. Important factors leading to ischemic heart disease and strokes are hypertension and high levels of homocysteine in blood serum. The coexistence of these two factors significantly increases the risk of these diseases and premature deaths. Many studies indicate that patients with hypertension are significantly more likely to demonstrate increased blood serum homocysteine levels than those with normal blood pressure. This may be caused by a higher incidence of overweight, high intake of salt and increased uric acid levels. It has been shown that both these factors increase the prevalence of hypertension and lead to higher homocysteine levels. However, the results of some studies indicate that arterial hypertension and homocysteinemia are causally related. It was shown, among other things, that high homocysteine levels damage the endothelium and reduce nitric oxide synthesis, which may directly lead to hypertension. Serum homocysteine levels are slightly higher in patients with white coat hypertension than they are in healthy individuals and may therefore also increase the risk of cardiovascular diseases. Several authors have also shown that the levels of homocysteine in blood serum are higher in so-called non-dippers, i.e., patients with no night-time pressure drop. The lack of a 10%–20% decrease in blood pressure at night is associated with increased cardiovascular complications. Strokes occur especially frequently in older people with arterial hypertension and hyperhomocysteinemia. The administration of B vitamins and folic acid significantly reduces serum homocysteine levels. The administration of this acid also slightly, but statistically significantly, increases the effectiveness of hypotensive drugs. Large meta-analyses meta-analysis indicate that the increased supply of folic acid in patients with hypertension significantly reduces the risk of stroke. Such management is particularly effective in patients with hypertension and hyperhomocysteinemia.
Suplementy diety – specyficzna żywność
Authors: Brzezińska Joanna , Grembecka Małgorzata 
Published: November 2021

Abstrakt
Rynek suplementów diety rozwija się bardzo dynamicznie, co ma związek z rozpowszechnieniem tej kategorii produktów w środkach masowego przekazu, stosunkowo bezproblemową procedurą wprowadzenia na polski rynek oraz powszechną dostępnością (można je nabyć w aptece, sklepach zielarskich, spożywczych oraz w Internecie). Z definicji suplementy mają być uzupełnieniem diety, zaliczają się do żywności oraz nie mogą wykazywać działania leczniczego. Ich postać, która została ustawowo określona, może być wizualnie identyczna z postacią farmaceutyczną produktów leczniczych, co może wprowadzać konsumentów w błąd, jeżeli nie wiedzą, jak rozróżniać te dwie grupy. Polska legislacja nie uwzględnia żadnych wymogów dotyczących parametrów technologicznych czy właściwości fizycznych gotowych produktów. Na bezpieczeństwo stosowania suplementów diety, oprócz ich jakości i rzeczywistej zawartości deklarowanych składników, składa się również ewentualna obecność zanieczyszczeń i niedozwolonych substancji dodatkowych. Wybiórcza kontrola rynku oraz brak szczegółowych wytycznych dotyczących parametrów postaci suplementów daje znaczną dowolność producentom, jednocześnie umożliwia wprowadzenie na rynek produktów o wątpliwej jakości, które mogą zagrażać konsumentom, będąc całkowicie pozbawionymi działania prozdrowotnego. Ze względu na rosnące zainteresowanie tą grupą produktów przez konsumentów, przedstawiono w pracy sytuację prawną suplementów diety na polskim rynku, odnosząc się także do legislacji europejskiej i amerykańskiej. Omówiono procedurę wprowadzania na rynek, podstawowe wytyczne stawiane tej grupie produktów, wskazania do stosowania oraz aspekty związane z bezpieczeństwem i zagrożeniami wynikającymi ze stosowania suplementów diety.