bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feeding and condition shifts after encountering a pathogen
Authors: Reyes-Ramírez Alicia , Rocha-Ortega Maya , Córdoba-Aguilar Alex 
Published: May 2021

Abstract
Feeding behaviour is a dynamic process, especially if an individual is dealing with an infection. Here, we used Tenebrio molitor beetles to evaluate the effects of changes in diet macronutrients (protein:carbohydrate) on: (i) feeding behaviour before and after infection (using the entomopathogenic fungus Metarhizium robertsii) in males; and (ii) body condition, measured as the amount of proteins, carbohydrates, and lipids in the body, in males and females. Given that females also depend on the nutrients from the spermatophore, we also addressed the impact on female condition of using spermatophores from males whose diets differed in macronutrients whether they were confronting an infection. We found that males with different diets and regardless of their infection status, and females with different diets, all consumed less of the protein-rich diet but more of the carbohydrate-rich diet. In addition, infection in males produced anorexia. The infection resulted in males and the females they mated with, with fewer body proteins and lipids. This suggests that unlike studies in other insects, T. molitor does not consume large amounts of protein during the adult stage, even during an infection. Females’ condition depended strongly on that of their mates, improving even when paired with infected males. This implies that females may be using the nutrients that the males transfer during mating for maintenance.
Constitutional Judicial Review and International Obligations of Criminalization
Authors: Bonafè Beatrice I. 
Published: May 2021

Abstract
The main purpose of this article is to investigate the role that international obligations of criminalization do play and could play in the judicial review carried out by the Italian Constitutional Court. It is divided into three main parts. The Court’s case law is examined first, a general and theoretical appraisal of the Court’s approach follows, and further implications of that approach are taken into account at the end. The author maintains that the Court is quite deferential to international obligations and, despite the significant constitutional constraints surrounding criminal law-making, it seems prepared to let criminalization obligations have various legal effects in the Italian national legal order.
“Untold Stories of Issei Women: Collective Images and Individual Experiences in Japanese American Oral History”
Authors: Okamura Ryoko 
Published: May 2021

Abstract
This article examines the relationship between the Japanese American redress movement and the oral interviews of two Japanese immigrant women, known as Issei women. Focusing on the shared images of Issei women in the Japanese American community and the perspectives and self-representations of the interviewees in the oral interviews, it explores how cultural consensus produced stereotypical, collective images of Issei women as submissive, persevering, and quiet persons. As the redress movement progressed in the 1960s to the 1980s, the Japanese American community conducted oral history projects to preserve memories and legacies of their wartime experiences. There are dissimilarities between the original audio recordings and the published transcripts regarding the perspectives of Issei women. This article shows how the community’s desire to preserve idealized images of Issei men and women reduced the accuracy and nuances in the women’s self-representations and the complexities of family relations. Also, contrary to the collective images, Issei women demonstrated how they were independent, assertive, and open individuals expressing their perspectives, complicated emotions, and importance in the family.
Intransitive Atmosphere Dynamics Leading to Persistent Hot–Dry or Cold–Wet European Summers
Authors: Weiland Ruud Sperna , van der Wiel Karin , Selten Frank , Coumou Dim 
Published: May 2021

AbstractPersistent hot–dry or cold–wet summer weather can have significant impacts on agriculture, health, and the environment. For northwestern Europe, these weather regimes are typically linked to, respectively, blocked or zonal jet stream states. The fundamental dynamics underlying these circulation states are still poorly understood. Edward Lorenz postulated that summer circulation may be either fully or almost intransitive, implying that part of the phase space (capturing circulation variability) cannot be reached within one specific summer. If true, this would have major implications for the predictability of summer weather and our understanding of the drivers of interannual variability of summer weather. Here, we test the two Lorenz hypotheses (i.e., fully or almost intransitive) for European summer circulation, capitalizing on a newly available very large ensemble (2000 years) of present-day climate data in the fully coupled global climate model EC-Earth. Using self-organizing maps, we quantify the phase space of summer circulation and the trajectories through phase space in unprecedented detail. We show that, based on Markov assumptions, the summer circulation is strongly dependent on its initial state in early summer with the atmospheric memory ranging from 28 days up to ~45 days. The memory is particularly long if the initial state is either a blocked or a zonal flow state. Furthermore, we identify two groups of summers that are characterized by distinctly different trajectories through phase space, and that prefer either a blocked or zonal circulation state, respectively. These results suggest that intransitivity is indeed a fundamental property of the atmosphere and an important driver of interannual variability.
Near-field wind mixing and implications on parameterization from float observations
Authors: Inoue Ryuichiro , Osafune Satoshi 
Published: May 2021

AbstractA part of near-inertial wind energies dissipates locally below the surface mixed layer. Here, their role in the climate system is studied by adopting near-inertial near-field wind-mixing parameterization to a coarse-forward ocean general circulation model. After confirming a problem of the parameterization in the equatorial region, we investigate effects of near-field wind mixing due to storm track activities in the North Pacific. We found that, in the center of the Pacific Decadal Oscillation (PDO) around 170°W in the mid latitude, near-field wind mixing transfers the PDO signal into deeper layers. Since the results suggest that near-field wind mixing is important in the climate system, we also compared the parameterization with velocity observations by a float in the North Pacific. The float observed abrupt and local propagation of near-inertial internal waves and shear instabilities in the main thermocline along the Kuroshio Extension for 460 km. Vertical diffusivities inferred from the parameterization do not reproduce the enhanced diffusivities in the deeper layer inferred from the float. Wave-ray tracing indicates that wave trapping near the Kuroshio front is responsible for the elevated diffusivities. Therefore, enhanced mixing due to trapping should be included in the parameterization.
Populism, localism and democratic citizenship
Authors: Macedo Stephen 
Published: May 2021

This article articulates and explores a localist conception of citizenship that stands in contrast to more liberal, neoliberal and cosmopolitan conceptions. A localist orientation, and some real sympathy, is evident in specifically ethnographic accounts of voters who supported Trump, Brexit and populism more broadly, including such accounts by Arlie Hochschild, Robert Wuthnow, Kathy Cramer and Justin Gest. This localist orientation echoes the Antifederalist opponents of the American Constitution, Jacksonian Democrats, Tocqueville’s account of American democracy and the American populists. I consider both the virtues and vices of localism. The possible benefits include local practices of nested reciprocity, special obligations, specifically local ‘social bases of selfrespect’ – in the terminology of John Rawls – and feelings of belonging and home (what the Germans call Heimat). However, localism also has its downsides: its resources can empower prejudice and exclusion. I end with a reflection on localism and exclusion in Lorraine Hasberry’s A Raisin in the Sun.
Telemedicine for management of patients with lung cancer during COVID-19 in an Italian cancer institute: SmartDoc Project
Authors: Pardolesi Alessandro , Gherzi Lorenzo , Pastorino Ugo 
Published: May 2021

Background: Telemedicine, and particularly video-consulting, has rapidly accelerated since the coronavirus disease 2019 (COVID-19) pandemic outbreak. The role of e-healthcare for the management of patients with lung diseases is evolving. We report the results of the initial experience of the SmartDoc Project, a telemedicine program activated in a cancer center (Istituto Nazionale Tumori) at the epicenter of the COVID-19 pandemic onset in Italy. Method: The SmartDoc project was established to guarantee continuity of healthcare services for patients with lung cancer during the COVID-19 pandemic crisis. The project was promoted within the National Health System to create a regulatory framework to authorize and reimburse telemedicine in its care delivery for all patients. At the end of the virtual meeting, patients were asked to answer an online survey. Results: From June 19 to December 1, 2020, 83 patients participated in the SmartDoc project and received a teleconsultation. The majority of patients were older than 65 years. Among the 83 televisits, 14 (16.9%) were new visits, 2 (2.4%) second opinions, 4 (4.8%) 30-day postsurgery controls, and 63 (75.9%) long-term follow-up visits. A “complete satisfaction” score (5 out of 5 points) was reported in 70.59% of all the respondents; most patients (76.5%) preferred video-consulting and defined it as better than or comparable to an in-person visit. Conclusion: The favorable initial results of this study suggest that telemedicine should continue beyond the pandemic crisis and should be embedded in a more efficient and accessible healthcare system.
Novel external stenting for reconstruction of high flow arteriovenous fistula
Authors: Matoussevitch Vladimir , Kalmykov Egan , Shahverdyan Robert 
Published: May 2021

Background: High-flow arteriovenous fistulae (HF-AVF) may lead to adverse cardiac remodeling in hemodialysis patients. We have investigated whether a novel external stent is safe and effective in reducing and stabilizing flow rates during a 1-year follow-up after HF-AVF reconstruction. Methods: All patients with HF-AVF (access flow rate ⩾ 1500 ml/min), who underwent HF-AVF reconstruction with external stenting in two centers between June 2018 and May 2020, were included in this retrospective analysis. During HF-AVF reconstruction, the dilated vein segment was resected, underwent volume reduction, and was externally stabilized using a braided cobalt-chromium external stent. AVF flow rates were assessed preoperatively, intraoperatively, and at follow up visits using duplex ultrasound. Results: Forty-three HF-AVFs in 42 patients were reconstructed and supported with an external stent (mean age 49 years, range 20–86 years; 74% men). Fifty-one percent were forearm AVFs, 49% were upper arm. The mean preoperative flow rate was 2622 ± 893 ml/min (range: 1500–6000 ml/min) and was decreased to 710 ± 221 ml/min (range: 300–1300 ml/min) intra-operatively after HF-AVF reconstruction. At 6 and 12-months follow-up, the mean flow rates were 1132 ± 320 ml/min (range: 470–1700 ml/min) and 1453 ± 888 ml/min (range: 300–3800 ml/min), respectively. Recurrence of high flow (>1500 ml/min) occurred in 16% and 25% of the patients at 6 and 12 months and primary patency rates were 86% and 70%, respectively. Conclusions: This early experience with novel external stenting for HF-AVF reconstruction demonstrates that it is a safe and effective method for reducing and stabilizing flow rates up to 1-year post procedure. Additional studies are required to evaluate the durability of this procedure over the longer term and assess its effect on cardiac remodeling.
Effects of delayed suprapubic port removal on post-laparoscopic shoulder pain: a randomized controlled trial
Authors: Chalermchockcharoenkit Amphan , Hengrasmee Pattaya , Sophontanarak Paiboon , Sirimai Korakot , Sutchritpongsa Pavit , Srichaikul Pisutt 
Published: May 2021

Abstract
Background
One of the major drawbacks of gynecologic laparoscopy is post-laparoscopic shoulder pain (PLSP) that is believed to result from intra-abdominal CO2 retention leading to peritoneal and diaphragmatic stretching and causing referred pain in C4 dermatome. Several interventions have been applied to prevent and reduce its incidence and severity, with contradictory results. Only pulmonary recruitment maneuver, extended assisted ventilation, and active intra-abdominal gas aspiration have been mentioned to be effective interventions for CO2 evacuation. However, in our experience, an alternative technique of delayed suprapubic port removal (DSPR) was found to be an effective method in CO2 expulsion. Therefore, we conducted this randomized trial to determine the effectiveness of the DSPR technique in reducing the incidence and severity of PLSP. The trial was conducted at a single, tertiary hospital between May 2015 and May 2016. Having complied with the criteria, 220 patients scheduled for elective gynecological laparoscopy were randomly allocated into 2 groups after giving informed consent. Laparoscopic procedures were performed through 10-mm umbilical port and at least 2 ancillary, including suprapubic, ports. In conventional group, ancillary ports were removed at the end of surgery leaving only opened umbilical cannula for pneumoperitoneum deflation. Abdominal compression from periphery towards umbilicus was performed to further expel CO2 before removing the umbilical cannula. In DSPR group, both umbilical and suprapubic cannulas were retained. Two-step abdominal compression was undertaken, primarily towards umbilicus and secondarily towards pelvic cavity, before sequentially removing the umbilical and the suprapubic cannulas. Postoperatively, each patient was asked to rate PLSP level on 100-mm VAS during 0–6, 6–12, 12–24, and 24–48 h, respectively. Statistical analysis was performed to determine both incidence and severity of PLSP during 24- and 48-h post-laparoscopy.

Results
Patients in DSPR group demonstrated significantly lower incidence of PLSP within 24 h (43.8% vs 59.0%; p = 0.027) and 48 h (43.8% vs 60.0%; p = 0.019), and expressed apparently lower pain scores (0 (0–0) vs 0 (0–8); p = 0.020) during 24–48 h post-surgery.

Conclusion
DSPR is an effective CO2 expulsion technique, resulting in significant reduction of both incidence and severity of PLSP within 24–48 h post-laparoscopy.

Trial registration
Thai Clinical Trials Registry, TCTR20160208003. Registered 8 February 2016 — retrospectively registered; http://www.thaiclinicaltrials.org/
The effects of interventional mitral valve repair using the MitraClip System on the results of pulmonary function testing, pulmonary pressure and diffusing capacity of the lung
Authors: Kretzler Lucie , Große Stephan , Wiedemann Stephan , Wunderlich Carsten , Nowak Chris , Riedel Christian , Sieger Tomáš , Schoen Steffen 
Published: May 2021

Abstract
Background
The study analyzes changes in lung function, pulmonary pressure and diffusing capacity of the lung in patients with mitral valve regurgitation (MR) treated by MitraClip implantation.

Methods
A total of 43 patients (19 women and 24 men with an average age of 78.0 ± 6.6 years) who were able to perform pulmonary function testing including diffusing capacity of the lung for carbon monoxide (DLCO), vital capacity (VC), total lung capacity (TLC), residual volume (RV) and forced expiratory volume in 1 s (FEV1) before and 6 weeks after MitraClip implantation participated in this study. Furthermore, clinical and echocardiographic parameters including systolic pulmonary artery pressure (sPAP), left ventricular ejection fraction (LVEF) and left atrial diameter (LAD) measurements were recorded in all patients.

Results
The procedure was performed successfully in all 43 patients leading to a reduction of MR in 97.7% of cases. One patient died on day 4 after the intervention most likely due to pulmonary artery embolism. Six weeks after the implantation 79.1% of patients showed a MR of at most mild to moderate. Furthermore, we could demonstrate a significant reduction of systolic pulmonary artery pressure during follow-up (from 48.8 ± 11.4 mmHg to 42.9 ± 9.0 mmHg (t(41) = − 2.6, p = 0.01). However, no changes in LVEF were detected. Comparing pre and post implant lung function tests, no significant alterations were seen for VC, TLC, DLCO and FEV1. Though, in a subgroup of patients with moderate to severe preexisting deterioration of DLCO at the baseline (max. 50%) the MitraClip procedure resulted in a significant improvement in DLCO (37.8% ± 9.0 to 41.6% ± 10.0, p < 0.001).

Conclusions
Treatment of MR with the MitraClip system successfully reduces MR severity in the vast majority of patients. Consecutively, a reduction in pulmonary pressure could be observed, however no changes in LVEF were obvious. Lung function tests remained unaltered during follow-up. However, in a subgroup of patients with severe preexisting deterioration of DLCO the MitraClip procedure resulted in a significant improvement in DLCO.

Trial registration
Name of the registry: Die Auswirkung der interventionellen Mitralklappenreparatur mit MitraClip-System auf die Ergebnisse der Lungenfunktionsmessung.

Trial registration number
DRKS00022435; Date of registration: 09/07/2020 'Retrospectively registered'; URL of trial registry record: https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00022435.
Subdivision of de-novo metastatic nasopharyngeal carcinoma based on tumor burden and pretreatment EBV DNA for therapeutic guidance of locoregional radiotherapy
Authors: Yang Jin-Hao , Sun Xue-Song , Xiao Bei-Bei , Liu Li-Ting , Guo Shan-Shan , Liang Jia-Dong , Jia Guo-Dong , Tang Lin-Quan , Chen Qiu-Yan , Mai Hai-Qiang 
Published: May 2021

Abstract
Background
Nasopharyngeal carcinoma (NPC) is a malignancy predominantly associated with infection by the Epstein-Barr virus (EBV). Approximately 12,900 new cases of NPC occur each year, with more than 70% of cases occurring in the east and southeast Asia. NPC is different from ordinary head and neck squamous cell carcinoma due to its particular biological properties and it is highly sensitive to radiotherapy. With the development of RT technology, the 3-year local control rate and survival rates of non-metastatic NPC reached 80–90% in the intensity-modulated RT (IMRT) era. However, whether distant metastatic NPC (de novo mNPC, dmNPC) should receive locoregional RT (LRRT) needs to be clarified.

Results
Multivariate analysis identified three independent prognostic factors: Epstein-Barr virus (EBV) DNA, number of metastatic lesions, and number of metastatic organs. Through these factors, all patients were successfully divided into 3 subgroups: low-risk (single metastatic organ, EBV DNA ≤ 25,000 copies/ml, and ≤ 5 metastatic lesions), intermediate-risk (single metastatic organ, EBV DNA > 25,000 copies/ml, and ≤ 5 metastatic lesions), and high-risk (multiple metastatic organs or > 5 metastatic lesions or both). By comparing LRRT and non-LRRT groups, statistical differences were found in OS in the low-risk and intermediate-risk subgroups (p = 0.039 and p = 0.010, respectively) but no significant difference was found in OS in the high-risk subgroup (p = 0.076). Further multivariate analysis of different risk stratifications revealed that LRRT can improve OS of low- and intermediate-risk subgroups.

Conclusions
The risk stratification of dmNPC may be used as a new prognostic factor to help clinicians organize individualized LRRT treatment to improve the survival outcomes of dmNPC patients.
Characteristics and recurrence of pterygium in Saudi Arabia: a single center study with a long follow‐up
Authors: Alsarhani Waleed , Alshahrani Saeed , Showail Mahmood , Alhabdan Nawaf , Alsumari Osama , Almalki Abdullah , Alsarhani Abdulaziz , Alluhaidan Adel , Alqahtani Bader 
Published: May 2021

Abstract
Background
This study described the clinical features of patients with pterygium and analyzed the recurrence rate of conjunctival autografting alone, conjunctival autografting combined with intraoperative mitomycin C, and amniotic membrane grafting.

Methods
A retrospective cohort study of primary pterygium was conducted between January 2017 and February 2020. Factors associated with pterygium severity and recurrence were analyzed by univariate analysis and logistic regression models.

Results
The study included 292 patients with an average age of 53.3 ± 14.1 years, while the number of operated cases was 94. Pterygia involving the cornea were observed in 55 % of the cases. The overall rate of recurrence for the three procedures was 17 %. The average time of recurrence was 14.2 ± 11.9 months, with 37 % of the recurrences occurring after the first year. The only factor associated with a significant risk of recurrence was dry eye disease in both univariate (p = 0.021) and multivariate analysis (p = 0.026). The recurrence rates following conjunctival autografting with and without mitomycin C were 15.6 and 15.8 %, respectively. The recurrence rate following the amniotic membrane graft was twofold (OR= 2.02) (27 %) that following the conjunctival autograft (15.8 %).

Conclusions
The only factor associated with the recurrence of pterygium was dry eye disease. More than one-third of recurrences developed after the first year, which stresses the importance of a long follow-up. The recurrence rate in our study following conjunctival graft was slightly higher compared to the literature mainly due to differences in study areas, populations, and follow-up periods.
Lower regional grey matter in alcohol use disorders: evidence from a voxel-based meta-analysis
Authors: Li Lei , Yu Hua , Liu Yihao , Meng Ya-jing , Li Xiao-jing , Zhang Chengcheng , Liang Sugai , Li Ming-li , Guo Wanjun , QiangWang  , Deng Wei , Ma Xiaohong , Coid Jeremy , Li Tao 
Published: May 2021

Abstract
Background
Previous research using whole-brain neuroimaging techniques has revealed structural differences of grey matter (GM) in alcohol use disorder (AUD) patients. However, some of the findings diverge from other neuroimaging studies and require further replication. The quantity of relevant research has, thus far, been limited and the association between GM and abstinence duration of AUD patients has not yet been systematically reviewed.

Methods
The present research conducted a meta-analysis of voxel-based GM studies in AUD patients published before Jan 2021. The study utilised a whole brain-based d-mapping approach to explore GM changes in AUD patients, and further analysed the relationship between GM deficits, abstinence duration and individual differences.

Results
The current research included 23 studies with a sample size of 846 AUD patients and 878 controls. The d-mapping approach identified lower GM in brain regions including the right cingulate gyrus, right insula and left middle frontal gyrus in AUD patients compared to controls. Meta-regression analyses found increasing GM atrophy in the right insula associated with the longer mean abstinence duration of the samples in the studies in our analysis. GM atrophy was also found positively correlated with the mean age of the samples in the right insula, and positively correlated with male ratio in the left middle frontal gyrus.

Conclusions
GM atrophy was found in the cingulate gyrus and insula in AUD patients. These findings align with published meta-analyses, suggesting they are potential deficits for AUD patients. Abstinence duration, age and gender also affect GM atrophy in AUD patients. This research provides some evidence of the underlying neuroanatomical nature of AUD.