bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interventions to support early childhood development in times of COVID-19: A systematic review protocol.
Authors: Bhamani Shelina , Rahim Komal , Tabani Alaina , Lassi Zohra 
Published: April 2021

Background: Coronavirus Disease 2019 (COVID-19), which came as an emerging disease, was announced as a pandemic by the World Health Organization in March 2020. In an attempt to limit this virus's spread, strict measures were taken, amongst which closure of schools and child care facilities were also present. This impacted the holistic well-being of the children. This systematic review aimed to identify early childhood development (ECD) interventions conducted and reported during the COVID-19 pandemic in low and middle-income countries and identify the barriers and facilitators to taking up ECD activities during the COVID-19 pandemic.
Methodology: A systematic literature explores all published and pre-print studies done during this pandemic starting from 31 Dec 2019 onwards using PRISMA guidelines. Databases such as MEDLINE, Embase, ERIC, CINAHL, the Cochrane Central Register of Controlled Trials (CENTRAL), Google Scholar, and the WHO COVID-19 database would be searched. All types of studies that are reporting ECD interventions and outcomes will be considered.
Discussion: The review will be one of the initiatives to support and provide directions for the programmatic agencies and academia to support post-Covid-19 interventions for the young children living in lower middle-income countries. By gathering the data pertinent to the interventions that were done during the times of lockdown for early childhood will also provide evidence to the programs of what has worked and how well it has worked for the nurturing care of children and their families.
Systematic review registration number: PROSPERO CRD42020202541
The Legal Istinbâth of Ibnu Qayyim Al-Jauziyah in the Terms of Medication and Health
Authors: Khatib Suansar 
Published: April 2021

The problem concern in this research is how the method of legal istinbâth of Ibn Qayyim al-Jauziyah about medication and health and its relevance with modern theory.This is normative legal research with library research methods, in the form of character studies. The source of the primary material is al-Thibbal Nabawi, supported by secondary materials, al-Dâ’u wa al-Dâwa’, and other relevant materials.Data analysis employed content analysis techniques, the material contained in the text was elaborated by comprehending the contents, then interpreted to obtain the legal istinbâth method regarding the method of medication and health. The results of this study showed that the method of legal istinbâth of Ibnu Qayyim al-Jauziyah in terms of medications, is guided by dilâlah ‘ibârah or ibârat nash, namely the Quran, Yûnus [10]: 57, Al-Isra’ [17]: 82, and clarified by the hadith of the Prophet Muhammad PBUH. While the method of legal istinbâth of Ibn Qayyim al-Jauziyah in health issues was refering to dillah ‘ibârah or ibârat nash, Al-Maidah [5]: 6, Al-’Araf [7]: 31, and made clear by the hadith. In terms of modern medication and health, the theory of therapy related to the process of medical action, is by maintaining body health through preventive action and expelling dangerous substances within the body.Fokus permasalahan dalam penelitian ini adalah bagaimana metode istinbâth hukum Ibnu Qayyim al-Jauziyah tentang pengobatan dan kesehatan?, dan bagaimana relevansi metode istinbâth hukumnya dengan teori pengobatan dan kesehatan modern?. Jenis penelitian ini merupakan penelitian hukum normatif dengan metode penelitian kepustakaan, dalam bentuk studi tokoh. Sumber bahan primernya yakni al-Thibbal-Nabawi,didukung oleh bahan sekunder yakni al-Dâ’u wa al-Dâwa’, dan bahan lainnya yang relevan. Analisis data menggunakan teknik analisis isi, materi yang terdapat dalam kandungan naskah dielaborasi dengan memahami makna yang terkandung dalam teks,lalu dilakukan interpretasi guna mendapatkan metode istinbâth hukumnya tentang metode pengobatan dan kesehatan. Hasil penelitian ini menemukan pertama,metode istinbâth hukum Ibnu Qayyim al-Jauziyah dalam masalah pengobatan berpedoman kepada dilâlah ‘ibârah atau ibârat nash yaitu Alquran surat Yûnus [10]: 57, Al-Isra’ [17]: 82, dan diperjelas oleh hadis Nabi. Sedangkan metode istinbâth hukum Ibnu Qayyim al-Jauziyah dalam masalah kesehatan merujuk kepada dilâlah ‘ibârah atau ibârat nash surat al-Maidah [5]: 6, Al-‘Araf [7]: 31, dan diperjelas oleh hadis Nabi. Relevansinya dengan pengobatan dan kesehatan modern, salah satunya teori tentang terapi yang terkait proses tindakan medis, yaitu dengan menjaga kesehatan tubuh melalui tindakan preventif dan melakukan proses pengusiran zat di tubuh yang menerima campuran zat berbahaya.
Perbedaan Kualitas Tidur Pada Lansia Sebelum Dan Sesudah Diberikan Rendaman Kaki Dengan Air Hangat
Authors: Roufuddin Roufuddin , Syaifuddin Mohammad 
Published: April 2021

Gangguan tidur dapat mengakibatkan masalah serius bahkan menurunkan kualitas hidup, hal ini sering terjadi pada lansia. Penelitian ini bertujuan untuk mengetahui perbedaan kualitas tidur pada lansia sebelum dan sesudah pemberian rendam kaki dengan air hangat di Desa Sukolilo Barat Bangkalan.
Jenis penelitian ini adalah pra-experiment design, dengan pendekatan one-group pretest-posttest design. Populasi sebanyak 41 lansia di Desa Sukolilo Barat, dan jumlah sampel sebanyak 30 lansia yang ditentukan dengan teknik purposive sampling. Variabel independen penelitian adalah rendam kaki dengan air hangat, variabel dependennya kualitas tidur pada lansia. Alat ukur dengan kuesioner PSQI. Uji statistik menggunakan Wilcoxon Rank Test.
Kualitas tidur sebelum dilakukan rendam kaki dengan air hangat dengan kualitas tidur kurang sebanyak 15 lansia (50%), 12 lansia cukup (40%), dan baik sebanyak 3 lansia. Kualitas tidur sesudah dilakukan rendam kaki dengan air hangat dengan kualitas tidur baik sebanyak 13 lansia (43,3%), 15 lansia cukup (50%), dan 2 lansia kurang. Dengan menggunakan uji Wilcoxon didapatkan nilai p value 0,000 (p< 0,05). Sehingga dapat disimpulkan ada perbedaan kualitas tidur pada lansia sebelum dan sesudah diberikan rendam kaki dengan air hangat.
Kualitas tidur bisa ditingkatkan bila lansia mengatahui faktor-faktor yang mempengaruhi kualitas tidur seperti faktor usia, lingkungan, makanan dan cara meningkatkan kualitas tidur dengan baik dan benar.
A propósito de un Debate. Aproximación a la crítica Literaria Peruana
Authors: Castañeda V. Esther 
Published: April 2021

En estos últimos años han aparecido publicaciones que intentan escapar a la rigidez y formalidad de los textos especializados, pretendiendo por el contrario capturar la frescura, amenidad y vitalidad de los diálogos. Centrados éstos sobre algunos temas significativos para la historia, el arte y la cultura, se logra no sólo matices variados, sino un haz de ideas sugerentes y motivadores de ulteriores estudios. Ejemplo de estas publicaciones son: Conversaciones entre L. A. Sánchez y José M. Oviedo; Conversaciones con Basadre (y Macera).
Pathogenetic relationship and ways of correction of H. pylori in patients with gastric and duodenal peptic ulcers in the combination of arterial hypertension and type 2 diabetes mellitus. Treatment of patient with H. pylori in presence of toxicogenic stra
Authors: Buzdugan I. O. , Fediv O. I. , Roborchuk S. V. , Voloshyna L. О. 
Published: April 2021

Objective — to investigate the functional state of endothelium and methods of correction of endothelial dysfunction in patients with gastric and duodenal peptic ulcers (GPU and DPU) in combination with hypertension (AH) and type 2 diabetes mellitus (DM2).
Materials and methods. The investigation involved 100 patients, who were divided into the groups: group 1 consisted of  20 apparently healthy individuals (AHI), group 2 included  40 patients with GPU (n = 23) and DPU (n = 17) without signs of AH and DM2, group 3 involved 40 patients with GPU (n = 15) and DPU (n = 25) in combination with hypertension and DM2. The groups were sub‑divided into subgroups A and B depending on the H. pylori strains’ toxigenicity: group A included patients with CagA+ VacA+ strains’ combination, groups B — infected with H. pylori with a combination of strains of CagA+ or VacA+. All patients were administered the traditional antihelicobacter therapy (AHBT) (esomeprazole 20 mg twice daily + amoxicillin 1.0 g twice daily + clarithromycin 500 mg twice daily for 10 days). To increase the effectiveness of eradication therapy, 40 patients in addition to AHBT, received a combined probiotic (Bifidobacterium bifidum, B. lactis, Enterococcusus acidophilus, L. paracasei, L. plantarum, L. rhamnosus, L. salivarius) 1 sachet twice a day for 1 month. Eradication control was monitored 4 weeks after completion of treatment.
Results. The increased expression of the vascular cell adhesion molecule‑1 (VCAM‑1) and the number of desquamated endothelial cells (DEK) and improvement of the oxidant‑antioxidant system have been established. Before the treatment, in comparison with the levels in AHI, levels of sVCAM exceeded in 5.88 times (р < 0.05), of erythrocytic malondialdehyde in 1.92 times (р < 0.05), and levels of the reduced glutathione was lower by 46.39 % (р < 0.05). The use of triple therapy improved the endothelial condition and the state of the oxidative‑antioxidant system, and additional application of probiotic promoted more effective correction of the indices of endothelial state and oxidative‑antioxidant system by means of maximal decrease of the levels of sVCAM and erythrocytic malondialdehyde and increase of the reduced glutathione levels.
Conclusions. The presence of H. pylori, in particular its toxigenic strains, results in the development of endothelial disfunction in patients with GPU and DPU, combined with arterial hypertension and DM 2. When combined with hypertension and DM2, the course of GPU and DPU is accompanied with «mutual burden» syndrome resulting in the exhaustion of the antioxidant defense system and increased indexes of the glutathione system.
Evaluation of the clinical effectiveness of the method for determining the personalized correction of the patient’s lifestyle and new promising predictors
Authors: Nevoit G. V. 
Published: April 2021

Objective — to assess the clinical and diagnostic efficiency of the method for determining the personified correction of the patient’s lifestyle targeted on the increase the effectiveness of measures for the prevention and treatment of non‑communicable diseases in Ukraine.
Materials and methods. Method of the direct assessment of the personified correction of the patient’s lifestyle was applied to 247 respondents (60 functionally healthy athletes, 111 functionally healthy non‑athletes, 76 patients with NCDs) in the open, non‑randomized, controlled study using valeological testing, instrumental bioimpedance measurement, and analysis of a short recording of Heart Rate Variability.
Results. Cluster differences have been reveled between the groups as regards the formation of a healthy lifestyle; non‑compliance with the principles of healthy lifestyle in the groups of functionally healthy non‑athletes and patients with NCDs, which was confirmed by significant difference in the indicators of body composition (deficiency of muscle mass, impaired fat metabolism), spectral analysis, variational pulsometry is a short recording of heart rate variability.
Results. Cluster differences in the formation of the level of a healthy lifestyle, non‑compliance with the principles of healthy lifestyle in the groups of functionally healthy non‑athletes with NCDs were found. This was confirmed by personalized analysis data, significant differences in body composition indicators (lack of muscle mass, impaired fat metabolism), spectral analysis, variational pulsometry, short recording of heart rate variability.
Conclusions. The method for determining the personalized correction of the patient’s lifestyle is an effective method for identifying and preventing non‑communicable diseases, in particular at account of the possibility to assess the novel early predictors — the content of muscle tissue and the functional state of the body based on the results of the analysis of a short recording of heart rate variability.
Ultrasonographic profile of non-alcoholic fatty liver disease manifestation in patients with hypertension
Authors: Rozhdestvenska A. O. 
Published: April 2021

Objective — to determine the features of liver ultrasonographic parameters in patients with combination of non‑alcoholic fatty liver disease (NAFLD) and hypertension (HT).
Materials and methods. The investigation involved 115 patients with NAFLD at the stage of non‑alcoholic steatohepatitis. The main group (n = 63) consisted of patients with comorbid NAFLD and HT, the comparison group (n = 52) included patients with isolated NAFLD, and the control group consisted of 20 apparently healthy individuals. Based on the results of clinical and laboratory tests, indices of the degree of liver fibrosis were calculated: Fibrosis‑4 (FIB‑4) and NAFLD fibrosis score (NFS). A comprehensive assessment of ultrasonographic signs of liver and surrounding organs damage and a semi‑quantitative assessment of liver steatosis according to the Ultrasound fatty liver indicator (US‑FLI) scale was performed during ultrasound examinations.
Results. Among the main ultrasound signs of steatosis, a significant liver size increase, liver parenchyma hyperechogenicity, changes in the vascular pattern, a hepatic portal system overload were found in all patients with NAFLD and HT. The average US‑FLI test result in the group with comorbid NAFLD and HT was 6 points (95 % CI 5.24; 6.12). This value was significantly higher compared to the group with isolated NAFLD, where the results averaged 3 points (95 % CI 2.91; 3.74; p < 0.001). FIB‑4 and NFS indices were also significantly higher in patients with NAFLD and HT. An increased risk of liver fibrosis was found in patients with comorbidity of NAFLD and HT. The significant effects of concomitant HT on the progression of fibrotic changes in the liver parenchyma in NAFLD have been determined.
Conclusions. Concomitant HT in patients with NAFLD introduces deviations in the ultrasonographic profile of the liver. It is manifested by a significantly more frequent detection of the main signs of steatosis, more expressive changes in quantitative ultrasound parameters and qualitative signs of liver steatosis according to the US‑FLI test. The non‑invasive fibrosis tests results indicate an intensification of fibrosis processes in the liver parenchyma in patients with NAFLD and HT. The obtained data allow us to consider HT as a trigger factor for the progression of liver fibrotic changes in patients with NAFLD.
Proton pump inhibitors: important information for cardiologists
Authors: Dolzhenko M. M. , Davydova I. V. 
Published: April 2021

Thromboembolic disorders occupy an important place in the structure of cardiovascular pathologies. Anticoagulants and antiplatelet agents proved to be the most efficient preventive medications for this group of patients, they enable reduction of the risk for both primary and secondary thromboembolic complications. However, their main shortcoming is the high potential of serious adverse events, basically related to gastrointestinal tract. That’s why, to prevent stress ulcers and bleedings in these patients, administration of antiplatelet agents, thrombolysis and heparin therapy is obligatory combined with the proton pump inhibitors. The authors presented data of evidence‑based medicine regarding one of the proton pump inhibitors, Ezolong, that contains esomeprazole (branded generic of Organosyn company). This combined medication is a modern formulation with the improved properties and more prolonged and predictable effect. Apart from its high protective efficacy, Ezolong is well tolerated, which is explained by the peculiarities of its pharmacodynamics and pharmacokinetics. Based on the complex of its clinical effects and safety profile, it is the drug of choice for patients with cardiovascular diseases. Ezolong is marketed in various formulations. Availability of its injectable formulation allows to achieve a quick intake of the active substance into the body, which is important for the therapy of acute pathologies and in case of impossibility of oral administration of the drug. Capsulated Ezolong provides easy administration, dosing accuracy, high adherence to the therapy of patients receiving outpatient treatment.
Comorbid conditions at chronic obstructive pulmonary disease: the questions under investigation and discussion
Authors: Lemko O. I. , Haysak M. O. , Reshetar D. V. 
Published: April 2021

Today, chronic obstructive pulmonary disease is considered as a multifactorial disease with systemic extrapulmonary manifestations and a high level of comorbidity. Differentiation of the polymorbidity and comorbidity concepts for patients with this pathology is very important. The common trigger factors and/or pathogenetic mechanisms lay in the basis of comorbid conditions, and their progression is comparable in time with the underlying disease. This determines the necessity for appropriate integrated management of such patients. The presence of other diseases that are not related to the main pathological process through common causative factors and/or pathogenetic mechanisms should be regarded as concomitant and lying in the basis for polymorbidity. The domestic and foreign scientific literature data on the mechanisms of potential comorbid pathology in this group of patients have been summarized. Information concerning the leading role of oxidative stress and systemic inflammatory process of low intensity in the development of comorbidity in chronic obstructive pulmonary disease is presented. The mechanisms of their influence, relationship, discussion questions and actual data on genetic and molecular mechanisms of development of these pathological processes are highlighted. Special attention is paid to the metabolic processes that develop as a result of oxidative stress and systemic inflammation. In particular, it has been shown that systemic inflammation leads to the development of insulin resistance, diabetes and other metabolic disorders. Data is outlined, supporting rationale for stratification of the metabolic profiles or phenotypes, as well as the pathogenetic significance of endotoxemia. Endothelial dysfunction and associated diseases of the cardiovascular system are also the consequences of oxidative stress and systemic inflammation. The analysis has been performed for the peculiarities of the manifestations of some of them in this group of patients.
Pengembangan Model Creative Problem Solving (CPS) Untuk Meningkatkan Kemampuan Berpikir Reflektif Siswa
Authors: Sari Ayu Devita , Hastuti Sri , Asmiati Asmiati 
Published: April 2021

Penelitian ini bertujuan untuk mengembangkan model Creative Problem Solving berupa buku model dan perangkat pembelajaran untuk mengembangkan kemampuan berpikir reflektif siswa. Penelitian yang digunakan adalah jenis penelitian pengembangan atau R&D ( reseacrch and development). Namun penelitian dibatasi sampai pada tahap uji ahli, sehingga tahapan pengembangan ini dimulai dari studi pendahuluan, penyusunan pengembangan pembelajaran, validasi ahli. Subjek penelitian ini adalah 2 orang guru dan 2 orang dosen. Instrumen Penelitian ini berupa lembar validasi untuk ahli dan praktisi. Hasil penelitian ini adalah (1) desain model Creative Problem Solving (CPS), (2) perangkat pembelajaran berupa silabus, Rencana Pelaksanaan Pembelajaran (RPP) dan Lembar Kerja Peserta Didik (LKPD) dengan topik operasi SPLTV kelas X SMA Negeri 15 Bandar Lampung semester ganjil. Adapun hasil validasi meliputi: skor penilaian desain pengembangan model sebesar 92,5% oleh ahli model dan 95% untuk ahli materi; skor Silabus sebesar 98% untuk ahli materi 1 dan 94% untuk ahli materi 2; skor RPP sebesar 97% untuk ahli materi 1 dan 95% untuk ahli materi 2; Skor LKPD sebesar 91,67% untuk ahli materi 1 dan 94,44% untuk ahli materi 2; Skor Media sebesar 95% untuk ahli media dan 94% untuk ahli materi. Hasil validasi para ahli diperoleh bahwa pengembangan model Creative Problem Solving dan perangkat pembelajaran layak digunakan dan diimplementasikan setelah memenuhi kriteria valid dan praktis. Hal ini dapat dilihat dari hasil skor penilaian validator yang memiliki kriteria valid dan kategori sangat praktis. Berdasarkan penilaian para ahli, maka secara teoritis produk pengembangan Model Creative Problem Solving (CPS) dapat digunakan untuk meningkatkan Keteramplilan berpikir reflektif siswa.
Integrasi Budaya Aceh Kedalam Media Pembelajaran Matematika Interaktif Untuk Meningkatkan Hasil Belajar Siswa
Authors: Hadijah Siti , Aulia Laksmi , Eviyanti Cut Yuniza 
Published: April 2021

Dimasa pandemi proses pembelajaran tidak dimungkinkan untuk dilakukan secara langsung atau secara tatap muka. Agar proses pembelajaran tetap dapat berjalan sesuai tujuan pembelajaran diperlukan adanya media pembelajaran berbasis teknologi yang dapat digunakan untuk mendukung siswa melaksanakan kegiatan belajar dirumah. Namun media pembelajaran berbasis teknologi yang beredar saat ini sangat terbatas. Salah satu penyebab keterbatasan ini yaitu ketidaksesuaian media pembelajaran yang ada dengan karakteristik siswa atau dengan materi yang akan diajarkan. Untuk itu diperlukan media pembelajaran matematika berbasis teknologi yang sesuai dengan karateristik siswa. Media pembelajaran yang digunakan dalam penelitian ini disesuaikan dengan kebudayaan lokal yaitu kebudayaan aceh. Pentingnya mengintegrasikan budaya lokal kedalam media pembelajaran matematika adalah untuk pengenalan dan menambah kecintaan siswa terhadap budayanya. Penelitian ini bertujuan untuk meningkatkan hasil belajar siswa SDN 33 Banda Aceh menggunakan media pembelajaran matematika. Jenis penelitian yang dipakai adalah PTK. Instrumen yang digunakan dalam ujicoba yakni Lembar validasi Media Pembelajaran, lembar tes, dan angket respon siswa. Penelitian ini memberikan hasil bahwa ketuntasan hasil belajar matematika meningkat hal ini diketahui dari rata-rata skor hasil belajar matematika pada tes pengetahuan materi prasyarat adalah 44,64, kemudian rata-rata skor hasil belajar matematika pada siklus I adalah 66,18, dan meningkat menjadi 72,73 pada tes hasil belajar matematika siklus kedua.
Peningkatan Kemampuan Pemecahan Masalah dan Self Esteem Siswa Melalui Pembelajaran Humanistik Berbasis Pendidikan Matematika Realistik
Authors: Rista Lia , Eviyanti Cut Yuniza , Andriani Andriani 
Published: April 2021

Pemecahan masalah merupakan bagian dari kurikulum matematika yang sangat penting dalam dunia pendidikan saat ini. Karena dalam proses pembelajaran maupun penyelesaiannya, siswa dimungkinkan memperoleh pengalaman menggunakan pengetahuan serta keterampilan yang sudah dimiliki untuk diterapkan pada pemecahan masalah yang bersifat tidak rutin. Dalam menyelesaikan masalah tersebut, guru juga memiliki peran yang sangat penting. guru harus mengetahui bahwa anak perkembangan mentalnya telah cukup dan telah memiliki cukup pengetahuan dalam menyelesaian persoalan sehari-hari. Dalam hal ini, terjadinya peningkatan kemampuan pemecahan masalah matematika juga dibarengi dengan psikologi. Psikologi dalam hal ini adalah adanya kepribadian yang selalu memiliki rasa percaya diri dan berpikir positif. Salah satu kepribadian yang harus dimiliki siswa adalah self esteem. Tujuan umum dari penelitian ini adalah untuk mengetahui sejauh mana kemampuan pemecahan masalah matematis dan self esteeme siswa melalui pembelajaran humanistik berbasis Pendidikan Matematika Realistik (PMR) . Jenis penelitian adalah eksperimen dengan pendekatan kuantitatif. Sedangkan penilaian self esteem berupa angket. Berdasarkan hasil penelitian dapat disimpulkan bahwa Peningkatan kemampuan pemecahan masalah dan self esteem siswa yang memperoleh pembelajaran humanistik berbasis PMR lebihbaik daripada siswa yang memperoleh pembelajaran konvensional.