bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linked Nickel Oxide/Perovskite Interface Passivation for High‐Performance Textured Monolithic Tandem Solar Cells
Authors: Zhumagali Shynggys , Isikgor Furkan H. , Maity Partha , Yin Jun , Ugur Esma , De Bastiani Michele , Subbiah Anand S. , Mirabelli Alessandro James , Azmi Randi , Harrison George T. , Troughton Joel , Aydin Erkan , Liu Jiang , Allen Thomas , Rehman Atteq ur , Baran Derya , Mohammed Omar F. , De Wolf Stefaan 
Published: September 2021

AbstractSputtered nickel oxide (NiOx) is an attractive hole‐transport layer for efficient, stable, and large‐area p‐i‐n metal‐halide perovskite solar cells (PSCs). However, surface traps and undesirable chemical reactions at the NiOx/perovskite interface are limiting the performance of NiOx‐based PSCs. To address these issues simultaneously, an efficient NiOx/perovskite interface passivation strategy by using an organometallic dye molecule (N719) is reported. This molecule concurrently passivates NiOx and perovskite surface traps, and facilitates charge transport. Consequently, the power conversion efficiency (PCE) of single‐junction p‐i‐n PSCs increases from 17.3% to 20.4% (the highest reported value for sputtered‐NiOx based PSCs). Notably, the N719 molecule self‐anchors and conformally covers NiOx films deposited on complex surfaces. This enables highly efficient textured monolithic p‐i‐n perovskite/silicon tandem solar cells, reaching PCEs up to 26.2% (23.5% without dye passivation) with a high processing yield. The N719 layer also forms a barrier that prevents undesirable chemical reactions at the NiOx/perovskite interface, significantly improving device stability. These findings provide critical insights for improved passivation of the NiOx/perovskite interface, and the fabrication of highly efficient, robust, and large‐area perovskite‐based optoelectronic devices.
Detectability‐based controller design screening for processes under multiplicative cyberattacks
Authors: Narasimhan Shilpa , El‐Farra Nael H. , Ellis Matthew J. 
Published: September 2021

AbstractCyberattacks on process control systems (PCSs) may target communication links, compromising the data integrity. Cyberattack detection and mitigation are essential capabilities, as the consequences of a successful cyberattack on a PCS may be severe. While detectability may be viewed as a systems‐theoretic property, cyberattack detection in practice depends on the attack detection scheme used and the PCS design. This paper presents an approach for control parameter screening based on the detectability of sensor‐controller communication link multiplicative attacks. First, a residual set‐based condition for the undetectability of an attack is developed. A controller screening methodology aimed at identifying controller parameter choices that mask the detectability of an attack is presented. The proposed methodology can be used to incorporate the detectability of an attack as a criterion into conventional control design criteria (e.g., closed‐loop stability and economic considerations). Finally, the application of the controller screening methodology is demonstrated using two illustrative examples.
In‐Cell Generation of Anticancer Phenanthridine Through Bioorthogonal Cyclization in Antitumor Prodrug Development
Authors: Maslah Hichem , Skarbek Charles , Gourson Catherine , Plamont Marie‐Aude , Pethe Stéphanie , Jullien Ludovic , Le Saux Thomas , Labruère Raphaël 
Published: September 2021

AbstractPharmacological inactivation of antitumor drugs toward healthy cells is a critical factor in prodrug development. Typically, pharmaceutical chemists graft temporary moieties to existing antitumor drugs to reduce their pharmacological activity. Here, we report a platform able to generate the cytotoxic agent by intramolecular cyclization. Using phenanthridines as cytotoxic model compounds, we designed ring‐opened biaryl precursors that generated the phenanthridines through bioorthogonal irreversible imination. This reaction was triggered by reactive oxygen species, commonly overproduced in cancer cells, able to convert a vinyl boronate ester function into a ketone that subsequently reacted with a pendant aniline. An inactive precursor was shown to engender a cytotoxic phenanthridine against KB cancer cells. Moreover, the kinetic of cyclization of this prodrug was extremely rapid inside living cells of KB cancer spheroids so as to circumvent drug action.
Selymatra: A web application for protein‐profiling analysis of mass spectra
Authors: Nardone Davide , Ciaramella Angelo , Cerreta Mariangela , Pulcrano Salvatore , Bellenchi Gian C. , Leone Linda , Manco Giuseppe , Febbraio Ferdinando 
Published: September 2021

AbstractSurface enhanced laser desorption/ionization‐time of flight (SELDI‐TOF) mass spectrometry is a variant of the matrix‐assisted laser desorption/ionization‐time of flight (MALDI‐TOF) mass spectrometry. It is used in many cases especially for the analysis of protein profiling and for preliminary screening of biomarkers in complex samples. Unfortunately, these analyses are time consuming and protein identification is generally strictly limited. SELDI‐TOF analysis of mass spectra (SELYMATRA) is a web application (WA) developed to reduce these limitations by (i) automating the identification processes and (ii) introducing the possibility to predict proteins in complex mixtures from cells and tissues. The WA architectural pattern is the model‐view‐controller, commonly used in software development. The WA compares the mass value between two mass spectra (sample vs. control) to extract differences, and, according to the set parameters, it queries a local database to predict most likely proteins based on their masses and different expression amplification. The WA was validated in a cellular model overexpressing a tagged NURR1 receptor, being able to recognize the tagged protein in the profiling of transformed cells. A help page, including a description of parameters for WA use, is available on the website.
Schnelles Bauen durch Standardisierung und Vorfertigung – Straßenbrücken in Modulbauweise
Authors: Hierl Martin , Tresch Jürgen 
Published: September 2021

AbstractBauen im Bestand wird künftig die Regelbauweise im deutschen Straßennetz darstellen. Umso wichtiger ist es, in diesem Zusammenhang verkehrliche Einschränkungen möglichst zu verringern und die damit einhergehenden erhöhten Unfallgefährdungen, ökonomischen Folgen (Staukosten) und ökologischen Auswirkungen (Umweltverschmutzung) auf ein Minimum zu reduzieren. Kurze Bauzeiten bei gleichzeitig hohem Qualitätsstandard sind demnach in vielerlei Hinsicht wünschenswert. Ein wichtiger Baustein hierbei ist das Bauen mit standardisierten und vorgefertigten Bauteilen. Aufgrund der Vielzahl an Vorschriften, Richtzeichnungen und bereits vorhandenen Regelungen im Bereich des Brückenbaus ist dieses Fachgebiet des Bauwesens prinzipiell prädestiniert für standardisierte Bauweisen. Dennoch ist die Fertigteilbauweise in den letzten Jahrzehnten im Brückenbau im Gegensatz zu einigen Nachbarländern eher seltener realisiert worden. Die Marktsituation der vergangenen Jahrzehnte erlaubte es den Bauherren, die Bauwerke unter Ausschöpfung eines scheinbar schier unbegrenzten Pools an Ingenieuren und Fachkräften als Unikat zu planen und in Ortbeton herzustellen. Man berief sich darauf, dass Brücken in Fertigteilbauweise per se gestalterisch weniger gelingen. Dies sollte aber bei der Vielzahl an Brücken, bei denen dieser Aspekt eine untergeordnete Rolle spielt, nicht entscheidend sein. Letztlich gibt es viele ökologische und volkswirtschaftliche Gründe, sich der modularen Bauweise, wie sie im Folgenden vorgestellt wird, zu öffnen, insbesondere wenn auch der Brückenbau seinen Anteil an einem nachhaltigen Wandel der Baubranche leisten soll.
Schnelles Bauen – Motivation, Historie und Konzepte
Authors: Forman Patrick , Glock Christian , Mark Peter 
Published: September 2021

AbstractViele Bauwerke wie Brücken, Hochbauten oder Industrieanlagen sind aktuell durch neue zu ersetzen. Ihre (planmäßige) Nutzungszeit ist vorüber. Zudem besteht großer Bedarf an Wohnraum in den wachsenden Städten. Beide Bauarten, Ersatz wie Neubau, finden in engen Verkehrsnetzen statt, die durch Güter‐, Waren‐ und Personenverkehr bereits weitgehend ausgelastet sind. Schnelles Bauen – gemeint ist hier die Ausführung vor Ort – motiviert sich daraus in den Zielen, die Verkehrsnetze möglichst gering zusätzlich zu belasten und kurzfristig neue Bauwerke für die jeweilige Nutzung zur Verfügung zu stellen. Die Qualität bleibt erhalten. Der Beitrag stellt als Übersichtsartikel zum Sonderheft den Rahmen des Schnellbaus vor. Dies sind seine Motivation in Deutschland und Europa, seine historische Einordnung in die Bautätigkeit der letzten Jahrzehnte bzw. Jahrhunderte inkl. aktueller Forschungsansätze und Grundsätze, die für schnelle Bauausführungen wichtig sind.
Anatomy education for medical students in a virtual reality workspace: A pilot study
Authors: Nakai Kohga , Terada Satoshi , Takahara Ayaka , Hage Dany , Tubbs R. Shane , Iwanaga Joe 
Published: September 2021

AbstractThe COVID‐19 pandemic has posed a challenge for many medical schools, as they have had to adjust their curricula into an online format. This was particularly problematic for anatomy courses as in person dissections have historically been preferred for providing students with a three‐dimensional learning environment. In this study, we aim to share our experience with conducting anatomy lectures for medical student using a virtual reality (VR) workspace. Additionally, we discuss the advantages of using VR and expand on how it may be used to improve students' understanding of anatomy in comparison to various other online lecture formats. To do this, we utilized a post‐lecture survey to gain feedback from the medical students that participated in a VR anatomy workspace. We found that many of our participants expressed that having access to their course material from anywhere and anytime via a virtual space, and being able to manipulate anatomical structures by moving and modifying them provided the student with a strong advantage. Although there are still limitations, we hope that our experience will assist other anatomy teachers with improving their lecture methods, especially during the pandemic.
Restriction of congenital portosystemic shunt using the modified microvascular plug
Authors: Rao Sruti , Karuppasamy Karunakaravel , Radhakrishnan Kadakkal , Fagan Thomas E. 
Published: September 2021

AbstractCongenital portosystemic shunts (CPSS) may produce a variety of severe, clinically detrimental presentations. When indicated, closure is recommended; however, if the intrahepatic portal venous system (IPVS) is underdeveloped complete closure may not be possible and may result in severe acute portal hypertension. Staged restriction of CPSS flow by both surgical and complex transcatheter interventions has been successful in augmenting development of the IPVS such that complete occlusion of the CPSS can be performed. We report use of a modified microvascular plug to restrict CPSS flow with subsequent IPVS development and safe complete occlusion of CPSS.
Effects of cooking over the stability of fatty acids as bioactive compounds in enriched pasta with a fish by‐product
Authors: Ainsa Andrea , Iranzo Lorena , Honrado Adrián , Marquina Pedro , Roncalés Pedro , Beltrán José. A. , Calanche Juan 
Published: September 2021

AbstractBackground and objectivesFusilli pasta enriched with sea bass concentrate (Dicentrarchus labrax) was developed with the aim of increasing its content in proteins and especially in polyunsaturated fatty acids (PUFA) like Ω‐3. Pasta made from two types of cereals (wheat and spelt) and fish by‐product with or without a natural antioxidant were cooking prior to consumption, and nutritional and physicochemical characteristics were evaluated.FindingsEnriched developed pasta showed high levels of protein, fat, and fiber, and the fatty acid profiles confirmed a substantial enrichment in bioactive compounds (Ω‐3 fatty acids). The cooking of pasta before consumption was able to reduce bacterial loads guaranteeing food safety and improving nutritional availability. Furthermore, an increase in the MUFA and PUFA content was revealed, which could represent an advantage to offer a better source of functional ingredients (EPA & DHA).ConclusionsThe combination of heat from cooking with formulations containing antioxidants seems to offer a remarkable synergistic effect to preserve unsaturated fatty acids with desirable nutritional properties.Significance and noveltyPasta enriched with bioactive compounds from fish by‐product after cooking treatment before consumption appears to be an effectiveness option to improve healthy human nutrition.
Micellar Catalysis: Visible‐Light Mediated Imidazo[1,2‐a]pyridine C—H Amination with N‐Aminopyridinium Salt Accelerated by Surfactant in Water
Authors: Yang Zhonglie , Cao Kun , Peng Xiaoyan , Lin Li , Fan Danchen , Li Jun‐Long , Wang Jingxia , Zhang Xiaobin , Jiang Hezhong , Li Jiahong 
Published: September 2021

Main observation and conclusionA light‐promoted metal‐free protocol for the amination of imidazo[1,2‐a]pyridines with N‐aminopyridinium salt by the assistance of surfactants in water was reported, charactering mild and environmentally benign conditions, as well as great functional group tolerance. Micelles with negatively charged polar surface and hydrophobic core formed from sodium dodecyl sulfate serve as an ideal medium for visible‐light mediated radical reaction of cationic pyridine salt and imidazo[1,2‐a]pyridine in aqueous phase. The electrostatic interaction between positively charged N‐aminopyridinium and negatively charged surface of micelles is of great significance in this method.
Monitoring Aqueous Phase Reactions by Operando ATR‐IR Spectroscopy at High Temperature and Pressure: A Biomass Conversion Showcase
Authors: Khalili Khaled N. M. , de Peinder Peter , Bruijnincx Pieter C. A. , Weckhuysen Bert M. 
Published: September 2021

AbstractSpectroscopic insight into aqueous phase catalytic reactions under realistic conditions aids detailed understanding and fosters further improvements. However, this is also very challenging, particularly in the liquid phase, given the typically elevated temperatures and pressures employed. Here, we report an operando Attenuated Total Reflectance‐Infrared (ATR‐IR) spectroscopic method to monitor the Aqueous Phase Reforming (APR) of Kraft lignin at 225 °C and 30 bar over a Pt/Al2O3 catalyst. This is a showcase reaction, while the presented method developed is more generic. In addition to the high temperature and pressures conditions, spectral interference from bulk water is a major challenge. Other challenges include self‐absorption of IR light, molecular interactions, high substrate loadings and the noise resulting from water vapor and CO2. We present a protocol utilizing the temperature‐dependent single‐beam method to obtain high‐quality ATR‐IR spectra virtually free from temperature, background and matrix effects. The protocol allowed for effective correction for the aqueous solvent as a function of reaction temperature. A comparison with conventional spectral acquisition and correction shows the advantages of this approach.
Endoscopic resection of superficial non‐ampullary duodenal epithelial tumor
Authors: Kato Motohiko , Kanai Takanori , Yahagi Naohisa 
Published: September 2021

AbstractAlthough superficial non‐ampullary duodenal epithelial tumor (SNADET) was previously considered a rare disease, in recent years, the opportunities to detect and treat SNADET are increasing. Considering the high morbidity of pancreatoduodenectomy, endoscopic resection can be a treatment option that preserves the organs and contributes maintain patients’ quality of life. Endoscopic mucosal resection (EMR) is a standard treatment for relatively small lesions in gastrointestinal tracts, however, it is difficult because submucosal fibrosis frequently occurs due to the previous biopsy. Recently, some modified EMR techniques including underwater EMR (UEMR) and cold polypectomy (CP) have been proposed. In UEMR, the duodenal lumen is filled with water or saline and resected the targe lesion with a snare without injection into the submucosa. It would be a treatment option that could reduce candidates for ESD especially SNADET less than 20 mm. CP was reported as a safe and convenient means for SNADET. It would also be one of the standard treatments for diminutive lesions, though there remain some concerns on its resectability. ESD for SNADET is technically challenging, especially with an extremely high risk of adverse event (AE) with a reported bleeding rate of more than 20% and perforation rate up to about 40%. However, modified treatment techniques including the water pressure method and pocket creation method have been reported to potentially contribute to improving outcomes of ESD. Moreover, accumulated evidence shows closing the mucosal defect significantly reduces delayed adverse events after duodenal endoscopic treatments. Further studies are warranted to elucidate curative criteria, long‐term outcomes, and appropriate surveillance strategy.
Podoplanin is dispensable for mineralized tissue formation and maintenance in the Swiss outbred mouse background
Authors: Toda Nakamura Masako , Zhang Honghao , Guo Dayong , Ueharu Hiroki , Pan Haichun , Scott Greg , Harris Marie , Ray Manas , Feng Jiang Q. , Harris Stephen E. , Bonewald Lynda F. , Mishina Yuji 
Published: September 2021

SummaryPodoplanin, PDPN, is a mucin‐type transmembrane glycoprotein widely expressed in many tissues, including lung, kidney, lymph nodes, and mineralized tissues. Its function is critical for lymphatic formation, differentiation of type I alveolar epithelial lung cells, and for bone response to biomechanical loading. It has previously been shown that Pdpn null mice die at birth due to respiratory failure emphasizing the importance of Pdpn in alveolar lung development. During the course of generation of Pdpn mutant mice, we found that most Pdpn null mice in the 129S6 and C57BL6/J mixed genetic background die at the perinatal stage, similar to previously published studies with Pdpn null mice, while all Pdpn null mice bred with Swiss outbred mice survived. Surviving mutant mice in the 129S6 and C57BL6/J mixed genetic background showed alterations in the osteocyte lacunocanalicular network, especially reduced osteocyte canaliculi in the tibial cortex with increased tibial trabecular bone. However, adult Pdpn null mice in the Swiss outbred background showed no overt differences in their osteocyte lacunocnalicular network, bone density, and no overt differences when challenged with exercise. Together, these data suggest that genetic variations present in the Swiss outbred mice compensate for the loss of function of PDPN in lung, kidney, and bone.
An integrated population model to project viability of a northern bobwhite population in Ohio
Authors: Rosenblatt Connor J. , Gates Robert J. , Matthews Stephen N. , Peterman William E. , Stricker Nathan J. 
Published: September 2021

AbstractIncreased variation in interannual weather due to climate change can exert a powerful influence on the population dynamics of a species. Understanding the influence of severe weather is important for managing weather‐sensitive species. While best management practices target vital rates that are affected by weather, focusing on a single vital rate may not be sufficient if other vital rates are secondarily limiting. A comprehensive modeling framework to forecast future population dynamics while incorporating weather scenarios and vital rate variation within observed ranges that can be affected by management actions are necessary. A potential approach is to combine an integrated population model (IPM) with a population viability analysis (PVA) to generate novel insights about population dynamics. We used the northern bobwhite (Colinus virginianus), a rapidly declining gamebird sensitive to snowfall along the northern extents of the species' range, to demonstrate the utility of a coupled IPM‐PVA framework for projecting the response of a population to weather, management, and changes in vital rates. We created an IPM using two sources of count data spanning seven years, five years of winter survival data, and two years of breeding season demographics for a declining bobwhite population in southwestern Ohio during 2007–2015. Quasi‐extinction probability at the end of the decadal projection during 2019–2029 was 0.384–0.410 for mild, average, and severe winter weather scenarios. Quasi‐extinction probability declined to 0.326 with 20% improvement in nest success and summer survival rates. A concurrent 20% increase in winter survival further reduced quasi‐extinction probability to 0.263, which is a ˜36% reduction in quasi‐extinction probability compared with the baseline scenario with no changes in vital rates. These results suggest that long‐term viability of this population may depend on extensive management of winter habitat to improve survival but will also require management actions to improve fecundity after severe winters. Our modeling approach demonstrated how IPMs can be used to project population responses to future weather conditions and overcome some of the pitfalls of traditional PVA. The coupled framework presented here can serve as a tool for managers to make climate‐informed management decisions.