bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative Endoscopic Activity Predicts the Occurrence of Pouchitis After Ileal Pouch–Anal Anastomosis in Ulcerative Colitis: A Multicenter Retrospective Study in China
Authors: Xu Weimin , Tang Wenbo , Ding Wenjun , Hu Hang , Chen Wenhao , Qian Qun , Cui Long , Ding Zhao , Du Peng 
Published: September 2021

Background: Pouchitis is the most common long-term complication after ileal pouch–anal anastomosis (IPAA) in patients with ulcerative colitis (UC). Ulcerative colitis endoscopic index of severity (UCEIS) and Mayo endoscopic score (MES) are widely used indices to evaluate endoscopic activity. This study aimed to clarify the predictive value of preoperative endoscopic activity on the occurrence of pouchitis after IPAA.Methods: Data of patients with UC who underwent IPAA from January 2008 to January 2020 were collected retrospectively. UCEIS and MES were based on the preoperative colonoscopy findings of two independent endoscopists.Results: A total of 102 patients with a median follow-up of 5 (interquartile range, 2–9) years were included in the study. Among them, 21.6% developed pouchitis. Compared with MES, UCEIS had a stronger correlation with pouchitis disease activity index. UCEIS ≥ 7 had the most significant receiver-operating characteristic (ROC) curve area of 0.747 with a sensitivity of 68.2% and specificity of 81.2% in predicting pouchitis, which outperformed MES of 3 with an ROC area of 0.679 with a sensitivity of 54.5% and specificity of 81.2%. Furthermore, we found that UCEIS ≥ 7 was an independent risk factor for post-IPAA pouchitis [odds ratio (OR), 8.860; 95% CI, 1.969–39.865, p &lt; 0.001] with a higher risk than MES of 3 (OR, 5.200; 95% CI, 1.895–14.273; p = 0.001).Conclusion: Ulcerative colitis endoscopic index of severity performed better in predicting pouchitis after IPAA than MES. Earlier and more frequent postoperative colonoscopic surveillance should be considered in patients with preoperative UCEIS ≥ 7 to detect the occurrence of pouchitis earlier.
Magnetic Properties and SAR for Gadolinium-Doped Iron Oxide Nanoparticles Prepared by Hydrothermal Method
Authors: Kahil Heba , Faramawy Ahmed , El-Sayed Hesham , Abdel-Sattar Adel 
Published: September 2021

This study is an attempt to produce gadolinium-doped iron oxide nanoparticles for the purpose of utilization in magnetic fluid hyperthermia (MFH). Six gadolinium-doped iron oxide samples with varying gadolinium contents (GdxFe3−xO4,x=0, 0.02, 0.04, 0.06, 0.08, 0.1) were prepared using the hydrothermal method at 180 °C and high vapor pressure to incorporate gadolinium ions in the iron oxide structure. The samples were indexed as GdIO/x, with x varying from 0.0 to 0.1. The results reveal that gadolinium ions have a low solubility limit in the iron oxide lattice (x = 0.04). The addition of gadolinium caused distortion in the produced maghemite phase and formation of other phases. Based on X-ray diffraction (XRD) analysis and photoelectron spectroscopy (XPS), it was observed that gadolinium mostly crystalized as gadolinium hydroxide, Gd (OH)3 for gadolinium concentrations above the solubility limit. The measured magnetization values are consistent with the formed phases. The saturation magnetization values for all gadolinium-doped samples are lower than the undoped sample. The specific absorption rate (SAR) for the pure iron oxide samples was measured. Sample GdIO/0.04, pure iron oxide doped with gadolinium, showed the highest potential to produce heat at a frequency of 198 kHz. Therefore, the sample is considered to hold great promise as an MFH agent.
Biochemical Characterization of 13-Lipoxygenases of Arabidopsis thaliana
Authors: Maynard Daniel , Chibani Kamel , Schmidtpott Sonja , Seidel Thorsten , Spross Jens , Viehhauser Andrea , Dietz Karl-Josef 
Published: September 2021

13-lipoxygenases (13-LOX) catalyze the dioxygenation of various polyunsaturated fatty acids (PUFAs), of which α-linolenic acid (LeA) is converted to 13-S-hydroperoxyoctadeca-9, 11, 15-trienoic acid (13-HPOT), the precursor for the prostaglandin-like plant hormones cis-(+)-12-oxophytodienoic acid (12-OPDA) and methyl jasmonate (MJ). This study aimed for characterizing the four annotated A. thaliana 13-LOX enzymes (LOX2, LOX3, LOX4, and LOX6) focusing on synthesis of 12-OPDA and 4Z,7Z,10Z)-12-[[-(1S,5S)-4-oxo-5-(2Z)-pent-2-en-1yl] cyclopent-2-en-1yl] dodeca-4,7,10-trienoic acid (OCPD). In addition, we performed interaction studies of 13-LOXs with ions and molecules to advance our understanding of 13-LOX. Cell imaging indicated plastid targeting of fluorescent proteins fused to 13-LOXs-N-terminal extensions, supporting the prediction of 13-LOX localization to plastids. The apparent maximal velocity (Vmax app) values for LOX-catalyzed LeA oxidation were highest for LOX4 (128 nmol·s−1·mg protein−1), with a Km value of 5.8 µM. A. thaliana 13-LOXs, in cascade with 12-OPDA pathway enzymes, synthesized 12-OPDA and OCPD from LeA and docosahexaenoic acid, previously shown only for LOX6. The activities of the four isoforms were differently affected by physiologically relevant chemicals, such as Mg2+, Ca2+, Cu2+ and Cd2+, and by 12-OPDA and MJ. As demonstrated for LOX4, 12-OPDA inhibited enzymatic LeA hydroperoxidation, with half-maximal enzyme inhibition at 48 µM. Biochemical interactions, such as the sensitivity of LOX toward thiol-reactive agents belonging to cyclopentenone prostaglandins, are suggested to occur in human LOX homologs. Furthermore, we conclude that 13-LOXs are isoforms with rather specific functional and regulatory enzymatic features.
The Influence of OAT1 Density and Functionality on Indoxyl Sulfate Transport in the Human Proximal Tubule: An Integrated Computational and In Vitro Study
Authors: King Jasia , Mihaila Silvia M. , Ahmed Sabbir , Truckenmüller Roman , Giselbrecht Stefan , Masereeuw Rosalinde , Carlier Aurélie 
Published: September 2021

Research has shown that traditional dialysis is an insufficient long-term therapy for patients suffering from end-stage kidney disease due to the high retention of uremic toxins in the blood as a result of the absence of the active transport functionality of the proximal tubule (PT). The PT’s function is defined by the epithelial membrane transporters, which have an integral role in toxin clearance. However, the intricate PT transporter–toxin interactions are not fully explored, and it is challenging to decouple their effects in toxin removal in vitro. Computational models are necessary to unravel and quantify the toxin–transporter interactions and develop an alternative therapy to dialysis. This includes the bioartificial kidney, where the hollow dialysis fibers are covered with kidney epithelial cells. In this integrated experimental–computational study, we developed a PT computational model that focuses on indoxyl sulfate (IS) transport by organic anionic transporter 1 (OAT1), capturing the transporter density in detail along the basolateral cell membrane as well as the activity of the transporter and the inward boundary flux. The unknown parameter values of the OAT1 density (1.15×107 transporters µm−2), IS uptake (1.75×10−5 µM−1 s−1), and dissociation (4.18×10−4 s−1) were fitted and validated with experimental LC-MS/MS time-series data of the IS concentration. The computational model was expanded to incorporate albumin conformational changes present in uremic patients. The results suggest that IS removal in the physiological model was influenced mainly by transporter density and IS dissociation rate from OAT1 and not by the initial albumin concentration. While in uremic conditions considering albumin conformational changes, the rate-limiting factors were the transporter density and IS uptake rate, which were followed closely by the albumin-binding rate and IS dissociation rate. In summary, the results of this study provide an exciting avenue to help understand the toxin–transporter complexities in the PT and make better-informed decisions on bioartificial kidney designs and the underlining transporter-related issues in uremic patients.
A família do paciente com transtorno mental grave
Authors: Ferreira Laura Fornero Gomes , Couto Carla  Rosane Ouriques 
Published: September 2021

A atenção familiar é um componente essencial da Atenção Primária à Saúde (APS). É importante que equipes de APS se apoderem de instrumentos capazes de abordar integralmente as questões familiares envolvidas com o processo saúde-doença. O presente estudo teve como objetivo compreender a dinâmica de uma família que possui dois integrantes com doença mental (esquizofrenia) a partir da análise dos instrumentos Genograma, Ecomapa e Apgar Familiar. Além de evidenciar a importância do uso dessas ferramentas como vantagem para a amplificação da perspectiva sistêmica da doença, há auxílio na percepção da situação psicossocial pelos profissionais de saúde e família. A metodologia utilizada amparou-se nos princípios da abordagem familiar sistêmica, através de entrevistas familiares sucessivas com aplicação dos instrumentos mais comumente utilizados pela Medicina de Família e Comunidade, tendo como cenário o domicílio dos pacientes. Após análise das ferramentas concluiu-se que a abordagem facilitou o autoconhecimento familiar, o entendimento da doença e ampliou/aprofundou o diálogo e relacionamento entre os membros do núcleo familiar. Alcances fundamentais para a redução do sofrimento do paciente e sua família, além de promover maior qualidade na integralidade da atenção ofertada pelos diversos profissionais da equipe de saúde.
Tip 2 Diyabetli Bireylerde Seyahat Zevk mi? Yoksa Eziyet mi? Kalitatif Bir Yaklaşım
Authors: ŞENTÜRK Sibel , TERKES Nurten , AKÇA Derya 
Published: September 2021

Giriş ve Amaç: Bu araştırmanın amacı, tip 2 diyabetli bireylerin seyahatleri sırasında yaşadıkları zorlukları belirlemektir.
Gereç ve Yöntemler: Tanımlayıcı ve fenomenolojik desene sahip olan bu araştırma, en az bir yıldır tip 2 diyabet tanısı almış, çalışmanın yapıldığı tarihlerde dahiliye servisinde yatmakta olan ve çalışmaya katılmayı kabul eden toplam 14 birey ile tamamlanmıştır. Veriler, araştırmacılar tarafından geliştirilen yarı yapılandırılmış form ile yüz yüze görüşme tekniği kullanılarak 35-40 dakikada toplanmıştır. Görüşmeler boyunca tip 2 diyabetli bireylerin ifadeleri ses kayıt cihazı ile kayıt altına alınmıştır. Veriler, içerik analizi yöntemi ile değerlendirilmiştir.
Bulgular: Araştırmada “seyahatin anlamı”, “seyahat sırasında yaşanılan zorluklar” ve “baş etme stratejileri” olmak üzere üç tema belirlenmiştir. Araştırmaya katılan tip 2 diyabetli bireyler seyahati, savaşa hazırlanma, zorlu bir dağa tırmanış ve panik atak geçirmesine neden olabilecek bir kavram olarak tanımlamışlardır. Tip 2 diyabetli bireyler seyahatleri sırasında ilaçları ve insülini muhafaza etme, şeker ölçümü ve insülin uygulama, ayak problemleri, diyet programına uyum ve hipoglisemi/hiperglisemi atakları gibi zorluklar yaşadıklarını ifade etmişlerdir. Seyahat ile ilgili problemlerle başa çıkmak için seyahat öncesi ihtiyacı olabilecek tüm malzemeleri hazır bulundurdukları, gidecekleri yeri araştırdıkları, seyahat öncesi rutin kontrollerini yaptırıp hekim ve diyabet hemşiresinden bilgi aldıklarını belirtmişlerdir.
Sonuç: Araştırma sonucunda tip 2 diyabetli bireylerin seyahat sırasında uygulanan tedavi, diyet, ayak sağlığı ve insülin regülasyonu ile ilgili sorunlar yaşadıkları tespit edilmiştir. Tip 2 diyabetli bireylerin seyahat uygulamaları sırasında hekim ve diyabet hemşireleri tarafından diyabetik bakıma yönelik detaylı bir şekilde bilgilendirilmeleri gerekmektedir.
The Relationship between Patient Motivations with Dietary Compliance in Patients Diabetes Mellitus at Haruai Health Center
Authors: Pratiwi Anjar Padmi , Riduansyah Muhammad , E. M. Gaghauna Eirene 
Published: September 2021

One of the risk factors that affect the increase in blood sugar levels in diabetes mellitus is an irregular diet. To prevent this, it is necessary to comply with the diet. In order for patients to comply with diet therapy, self-motivation and external motivation are needed. To determine patient motivation, level of dietary compliance and the correlation between patient motivation and dietary compliance in diabetes mellitus patients at community Haruai.This study used a cross sectional approach. The sample technique was taken 25% of the total population by purposive sampling method, the sample size was 43. The results of this study indicated based on Sperman Rank (Rho) analysis there was a correlation between patient motivation and dietary compliance in diabetes mellitus patients at community Health Center Haruai with a p value of 0,000. There is a positive correlation between motivation and dietary compliance in diabetes mellitus patients, which means that the better the motivation of the patient, the better the dietary compliance is in the diabetes mellitus patient and both have a strong correlation.
EFEKTIVITAS PEMBERIAN SILASE LIMBAH IKAN UNTUK MENINGKATKAN PANJANG TULANG FEMUR, TIBIA DAN METATARSUS, PADA BEBEK PEDAGING
Authors: Sulistiyoningsih Mei , Rakhmawati Reni 
Published: September 2021

Tujuan penelitian ini adalah untuk mengetahui keefektifan pemberian silase limbah ikan dalam ransum terhadap panjang tulang tungkai, khususnya pada tulang femur, tibia dan metatarsus pada bebek pedaging. Subjek yang digunakan dalam penelitian ini adalah 100 ekor DOD (Day Old Duck). Rancangan yang di gunakan adalah Rancangan Acak Lengkap (RAL). Materi penelitian terdiri dari 3 perlakuan dengan 4 ulangan. Perlakuan dalam penelitian ini adalah P0 (Ransum komersial)/Kontrol, P1(Ransum komersial + 5% silase limbah ikan), dan P2 (Ransum komersial + 10% silase limbah ikan). Variable penelitian yang di ukur adalah tulang femur, tibia dan metatarsus pada bebek dengan menggunakan jangka sorong. Variabel kendalinya adalah manajemen kesehatan, jenis bebek, umur bebek, dan perkandangan. Data yang diperoleh selanjutnya dianalisis menggunakan sidik ragam (ANOVA) dengan taraf 5%. Hasil penelitian menunjukkan tidak ada pengaruh nyata (P > 0,05) terhadap panjang tulang femur, tibia dan metatarsus pada bebek pedaging.
Evaluasi Sistem Penjualan Tiket Pesawat Dan Kapal Laut Pada Wewe Travel Malang (Maks. 16 Kata)
Authors: Usatnoby Glaudiana M 
Published: September 2021

Penelitian ini bertujuan untuk mengetahui evaluasi sistem penjualan yang diterapkan pada Wewe travel. Penelitian ini juga diharapkan dapat menjadi masukan bagi manajemen perusahaan travel agar bisa membuat evaluasi sistem penjualan yang benar. Dalam penelitian ini peneliti akan membandingkan sistem penjualan yang sedang berjalan dan dan sistem yang diusulkan. Hasil penelitian menunjukkan bahwa evaluasi sistem penjualan yang sudah diterapkan memang belum sesuai dengan prosedur yang ada sehingga harus ada suslan sistem. Dengan adanya usulan sistem maka evaluasi sistem penjualan bisa berjalan dengan baik dan juga lebih efektif dan efisien.
Розвиток експортного потенціалу підприємств за умов глобалізації: фактори та пріоритети
Authors: Yurchenko O. , Kushnir O. 
Published: September 2021

В статті розглядаються проблемні питання формування і розвитку експортного потенціалу національних підприємств в умовах економічних криз глобального характеру. Враховується досвід формування експортного потенціалу з огляду на досвід порушення функціонування світових галузевих ринків, що спричинені протиепідемічними заходами та локдауном. Відзначається, що експорт відіграє особливу роль в оздоровленні економіки країни, особливо в умовах спаду внутрішнього виробництва. Адже кошти, що надходять від експортної діяльності, спрямовуються на погашення заборгованості, модернізацію, розв’язання соціально-економічних проблем. Розвиток експортного потенціалу розглядається як інтегральна діяльність підприємств. Відзначається важливість застосування різноманітних інструментів менеджменту для формування експортного потенціалу підприємства, а також необхідність визначати його пріоритети, зокрема модифікація складу функцій, оптимізація часу стійкості і нестійкості структури, підвищення рівня керованості, оптимізація шляхів реалізації з метою підвищення ефективності. Також приділено увагу формуванню та управлінню експортним потенціалом під час кризи. Адже вплив процесів глобалізації на розвиток експортного потенціалу має багатовимірний характер. Йдеться як про позитивні, так і негативні сторони інтеграції підприємств до світового господарства в контексті зовнішньої торгівлі, у тому числі експортних можливостей. Зокрема, йдеться про наслідки світової кризи, що пов’язана з обмеженнями для економічної активності підприємств, в умовах пандемії вірусу COVID-19. Таким чином, розглянувши поняття експортного потенціалу підприємства, шляхів його використання і підвищення та конкурентної стратегії країни, необхідно зазначити, що ці поняття нерозривно пов’язані між собою, а точніше, експортний потенціал кожного підприємства країни є однією з важливих складових, що дає їй змогу посідати гідне місце на міжнародній арені.
Türkiye’nin Şehir Sağlığı Politikalarının Sağlık Yönetimi Bakış Açısıyla Değerlendirilmesi
Authors: KOCAMAN Ersin , BAÇ Adnan , TERLEMEZ Bahriye 
Published: September 2021

Bireysel ve toplumsal sağlık değerinin artırılmasında şehir sağlığı politikaları önemli bir role sahiptir. Bu araştırmada, Türkiye’nin beş yıllık kalkınma planlarında (BYKP) yer alan şehir/kent ile ilgili politikaların tespit edilmesi ve tespit edilen politikaların Dünya Sağlık Örgütü Şehir Sağlık Profilinde yer alan dokuz başlıkta sınıflandırılarak incelenmesi amaçlanmaktadır.
Doküman incelemesi yönteminin kullanıldığı bu araştırmada, 1963- 2023 yıllarını kapsayan on bir tane BYKP incelenmiştir. Veriler, örneklem seçme, kategori geliştirme, analiz birimi saptama ve sayısallaştırma olmak üzere dört aşamada analiz edilmiştir. Verilerin analizinde ve görselleştirilmesinde MAXQDA 2020 ve Microsoft Excel programları kullanılmıştır.
Planlarda, 805 tane şehir sağlığı politikasının var olduğu; politikaların %51,3’nü (n:413) en son hazırlanan dört BYKP’de, en az politikanın Altıncı BYKP’de (n:26) ve en fazla politikanın On Birinci BYKP’de (n:142) yer aldığı belirlenmiştir. En az politikanın “Doğal ve Yapay Afetlere Karşı Dayanım” başlığında (n:15), en fazla politikanın ise “Yönetişim ve Katılım” başlığında (n:190) olduğu saptanmıştır. Plan başına düşen ortalama şehir sağlığı politika sayısı 73,18;, konu başlığı başına düşen ortalama politika sayısı 89,44’tür. Şehir sağlığı politikalarında en sık kullanılan kelimelerin “Sosyal”, “Sistem”, “Ulaşım”, “Su” ve “Koordinasyon” kelimeleri olduğu görülmüştür.
Planlarda yer alan şehir sağlığı politikalarının sayısında düzensiz olmakla birlikte ciddi bir artış olmuştur. Sağlık Hizmetleri, Nüfus Yapısı ve Demografik Eğilimler, Doğal ve Yapay Afetlere Karşı Dayanım konularında daha fazla politika üretilmesine ihtiyaç olduğu görülmektedir. Kalkınma planlarında yer alan şehir sağlığı politikalarının sayısının artırılması sağlık değerinin iyileştirilmesine katkı sağlayacaktır.
Components of a Digital Specimen Architecture for Biological Collections
Authors: Stewart Aimee 
Published: September 2021

In 2020, we began developing software components for an Application Programming Interface (API)-based integration architecture (the “Specify Network”) to leverage the global footprint of the Specify 7 collections management platform (www.specifysoftware.org) and the analytical services of the Lifemapper (lifemapper.org) and Biotaphy (biotaphy.org) Projects. The University of Kansas Lifemapper Project is a community gateway for species distribution and macroecological modeling. The Biotaphy Project, an extension of Lifemapper, is the product of a six-year, U.S. National Science Foundation-funded collaboration among researchers at the Universities of Michigan, Florida, and Kansas. Biotaphy's primary scope is to use big data methods and high-performance computing to integrate species occurrence data with phylogenetic and biogeographic data sets for large taxonomic and spatial scale analyses. Our initial integrations between Biotaphy and the Specify Network enable Specify users to easily discover remote information related to the specimens in their collection.
The widely-discussed, digital specimen architecture being championed by DiSSCo (Distributed System of Scientific Collections www.dissco.eu) and others (https://bit.ly/3jfsAgz) will change data communications between biodiversity collections and the broader biodiversity data community. Those network interactions will evolve from being predominantly one-way, batch-oriented transfers of information from museums to aggregators, to an n-way communications topology that will make specimen record discovery, updates and usage much easier to accomplish. But museum specimens and their catalogs will no longer be an intellectual endpoint of species documentation. Rather, records in collections management systems will increasingly serve as a point of departure for data synthesis, which takes place outside of institutional data domains, and which will overlay the legacy role of museums as authoritative sources of information about the diversity and distribution of life on Earth. Biological museum institutions will continue to play a vital role as the foundation of a global data infrastructure connecting aggregators, collaborative databases, analysis engines, journal publishers, and data set archives.
In this presentation, we will provide an update on the components and capabilities that make up integrations in the Specify Network as an exemplar of the global architecture envisaged by the biodiversity research community.
Use of a convolutional neural network to segment signals of motor operated valves
Authors: Kotsoyev Konstantin I. , Trykov Yevgeny L. , Trykova Irina V. 
Published: September 2021

Motor operated valves (MOV) are one of the most numerous classes of the nuclear power plant components. An important issue concerned with the MOV diagnostics is the lack of in-process (online) automated control for the MOV technical condition during full power operation of the NPP unit.
In this regard, a vital task is that of the MOV diagnostics based on the signals of the current and voltage consumed during MOV ‘opening’ and ‘closing’ operations. The current and voltage signals represent time series measured at regular intervals. The current (and voltage) signals can be received online and contain all necessary information for the online diagnostics of the MOV status.
Essentially, the approach allows active power signals to be calculated from the current and voltage signals, and characteristics (‘diagnostic signs’) to be extracted from particular portions (segments) of the active power signals using the values of which MOVs can be diagnosed.
The paper deals with the problem of automating the segmentation of active power signals. To accomplish this, an algorithm has been developed based on using a convolutional neural network.