bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation, Standardization and Anti-plasmodial Efficacy of Novel Malaria Nosodes
Authors: Suri Mansi , Walter Neha Sylvia , Katnoria Sapna , Gorki Varun , Manchanda Raj Kumar , Khurana Anil , Nayak Debadatta , Bagai Upma , Kaur Sukhbir 
Published: November 2021

AbstractBackground Resistance to artemisinin and its partner drugs has threatened the sustainability of continuing the global efforts to curb malaria, which urges the need to look for newer therapies to control the disease without any adverse side effects. In the present study, novel homeopathic nosodes were prepared from Plasmodium falciparum and also assessed for their in vitro and in vivo anti-plasmodial activity.Methods Three nosodes were prepared from P. falciparum (chloroquine [CQ]-sensitive [3D7] and CQ-resistant [RKL-9] strains) as per the Homeopathic Pharmacopoeia of India, viz. cell-free parasite nosode, infected RBCs nosode, mixture nosode. In vitro anti-malarial activity was assessed by schizont maturation inhibition assay. The in vitro cytotoxicity was evaluated by MTT assay. Knight and Peter's method was used to determine in vivo suppressive activity. Mice were inoculated with P. berghei-infected erythrocytes on day 1 and treatment was initiated on the same day. Biochemical, cytokine and histopathological analyses were carried out using standard methods.Results In vitro: the nosodes exhibited considerable activity against P. falciparum with maximum 71.42% (3D7) and 68.57% (RKL-9) inhibition by mixture nosode followed by cell-free parasite nosode (62.85% 3D7 and 60% RKL-9) and infected RBCs nosode (60.61% 3D7 and 57.14% RKL-9). The nosodes were non-toxic to RAW macrophage cell line with >70% cell viability. In vivo: Considerable suppressive efficacy was observed in mixture nosode-treated mice, with 0.005 ± 0.001% parasitemia on day 35. Levels of liver and kidney function biomarkers were within the normal range in the mixture nosode-treated groups. Cytokine analysis revealed increased levels of IL-4 and IL-10, whilst a decline in IL-17 and IFN-γ was evident in the mixture nosode-treated mice.Conclusion The mixture nosode exhibited promising anti-malarial activity against P. falciparum and P. berghei. Biochemical and histopathological studies also highlighted the safety of the nosode for the rodent host. The study provides valuable insight into a novel medicament that has potential for use in the treatment of malaria.
Análise da exposição intraoperatória ao raio X e do tempo cirúrgico em diferentes técnicas de fixação das fraturas transtrocanterianas do fêmur
Authors: Guerra Lucas Carneiro Curty Bastos , Chiarelli Leo Ribeiro 
Published: November 2021

Resumo
Objetivo Avaliar e comparar o tempo total do procedimento cirúrgico e a exposição ao raio X no intraoperatório em diferentes técnicas de fixação das fraturas transtrocanterianas do fêmur em pacientes idosos, utilizando técnicas extramedulares e intramedulares baseadas em parafuso de tração cefálico.
Métodos Foram avaliados no serviço de ortopedia e traumatologia do nosso hospital 107 pacientes com fraturas transtrocanterianas, sendo 34 do sexo masculino e 73 do sexo feminino, com idade mínima de 61 anos e máxima de 101 anos. As fraturas fixadas, utilizando a técnica com dynamic hip system (DHS, na sigla em inglês) somaram 21 pacientes; em 55 pacientes, foi utilizado o proximal femur nail (PFN, na sigla em inglês) standard; e em 31 idosos, foi optado pelo uso do gama nail standard. Todos os procedimentos foram realizados pelo mesmo cirurgião acompanhado de sua equipe de auxiliares de enfermagem, assim como pelo mesmo técnico de radiologia manuseando o mesmo intensificador de imagens. Foram avaliados o tempo total da cirurgia (em minutos) e a emissão de raios X medida em centigrays.
Resultados A fixação das fraturas transtrocanterianas com PFN proporciona um menor tempo cirúrgico com uma diferença estatística significativa (p = 0,013), quando comparada com as demais técnicas utilizadas entre os grupos envolvidos. Foi observada, também, uma menor exposição intraoperatória aos raios X (p = 0,015), a qual foi estatisticamente relevante quando utilizado o DHS como método de fixação comparado com o gama nail e o PFN.
Conclusão Apesar do PFN ter o menor tempo de cirurgia, a técnica do DHS se mostrou com menores níveis de exposição dentro da amostra estudada.
Fluorescence thermometry application of photoluminescence image from Cr-doped YAG
Authors: Katsumata Toru , Hanami Nobuyuki , Aizawa Hiroaki 
Published: November 2021

The temperature dependence of a photoluminescence (PL) image from a Cr-doped Y3Al5O12 (YAG:Cr) crystal was evaluated for a fluorescence thermometry application. The brightness of a red PL image of YAG:Cr was found to be increased by increasing the temperature. Temperature variations of the peak intensity and peak area of red PL related to the PL peaks at λ = 680, 690, 708, and 725 nm were evaluated to reveal the cause of the increase in brightness of the PL image. While intensities of the PL peaks at λ = 690, 690, and 708 nm decreased with temperature due to thermal quenching, the peak intensity at λ = 725 nm and the peak area increased with temperature up to 250 °C. The latter factor greatly affects the temperature variation of the brightness of PL images. The increase in the brightness of the PL image with temperature is evidently linked with the thermal excitation of electrons at the 2E level responsible for the increase in the PL peak area. Cr concentration suitable for the temperature sensor is suggested based on the temperature variation of the PL peak area.
Csi-let-7a-5p delivered by extracellular vesicles from a liver fluke activates M1-like macrophages and exacerbates biliary injuries
Authors: Yan Chao , Zhou Qian-Yang , Wu Jing , Xu Na , Du Ying , Li Jing , Liu Ji-Xin , Koda Stephane , Zhang Bei-Bei , Yu Qian , Yang Hui-Min , Li Xiang-Yang , Zhang Bo , Xu Yin-Hai , Chen Jia-Xu , Wu Zhongdao , Zhu Xing-Quan , Tang Ren-Xian , Zheng Kui-Yang 
Published: November 2021

SignificanceInfection with liver flukes (such asClonorchis sinensis) can induce severe biliary injuries. But we don’t know how it happens. Here, we find that a microRNA Csi-let-7a-5p delivered by extracellular vesicles fromC. sinensisis prone to M1-like activation of macrophages, thus leading to biliary proinflammatory responses and biliary injuries. These findings indicate a molecular mechanism contributing to biliary injuries caused byC. sinensis.
Haplotype-aware inference of human chromosome abnormalities
Authors: Ariad Daniel , Yan Stephanie M. , Victor Andrea R. , Barnes Frank L. , Zouves Christo G. , Viotti Manuel , McCoy Rajiv C. 
Published: November 2021

Significance
Whole-chromosome gains and losses (aneuploidies) are the leading cause of human pregnancy loss and congenital disorders. Recent work has demonstrated that in addition to harmful meiotic aneuploidies, mitotic aneuploidies (which lead to mosaic embryos harboring cells with different numbers of chromosomes) may also be common in preimplantation embryos but potentially compatible with healthy birth. Here we developed and tested a method for distinguishing these forms of aneuploidy using genetic testing data from 8,154 in vitro fertilization (IVF) embryos. We reclassified embryos based on signatures of meiotic and mitotic error, while also revealing lethal forms of chromosome abnormality that were previously hidden. Our method complements standard protocols for preimplantation genetic testing, while offering insight into the biology of early development.
Crony capitalism in Nigeria: the case of patronage funding of the Peoples Democratic Party and the power sector reform, 1999–2015
Authors: Albert Okorie , Abada Ifeanyichukwu , Adibe Raymond 
Published: November 2021

ABSTRACT
The article argues that cronyism in the funding of the Peoples Democratic Party (PDP) explains the dismal record of the recent power sector reforms in Nigeria. It implies that the reforms were packaged by the then PDP-led government to benefit their major campaign financiers with contracts; thus, within this period the party financiers were able to assume a commanding position in the sector. The article further contends that the funding regime in the party reinforces corruption as financiers leveraged on their contributions to the party to ensure that the reform processes and outcomes reflected their economic interests. The case exemplifies the crony relationship between the business and the political class (that ought to act as the regulatory body), which is skewed towards primitive accumulation.
Improved electronic structure prediction of chalcopyrite semiconductors from a semilocal density functional based on Pauli kinetic energy enhancement factor
Authors: Ghosh Arghya , Jana Subrata , Niranjan Manish K , Behera Sushant Kumar , Constantin Lucian A , Samal Prasanjit 
Published: November 2021

Abstract
The correct treatment of d electrons is of prime importance in order to predict the electronic properties of the prototype chalcopyrite semiconductors. The effect of d states is linked with the anion displacement parameter u, which in turn influences the bandgap of these systems. Semilocal exchange–correlation functionals which yield good structural properties of semiconductors and insulators often fail to predict reasonable u because of the underestimation of the bandgaps arising from the strong interplay between d electrons. In the present study, we show that the meta-generalized gradient approximation (meta-GGA) obtained from the cuspless hydrogen density (MGGAC) (2019 Phys. Rev. B 100 155140) performs in an improved manner in apprehending the key features of the electronic properties of chalcopyrites, and its bandgaps are comparative to that obtained using state-of-art hybrid methods. Moreover, the present assessment also shows the importance of the Pauli kinetic energy enhancement factor, α = (τ − τ

W
)/τ
unif in describing the d electrons in chalcopyrites. The present study strongly suggests that the MGGAC functional within semilocal approximations can be a better and preferred choice to study the chalcopyrites and other solid-state systems due to its superior performance and significantly low computational cost.
Large valley polarization in a novel two-dimensional semiconductor H-ZrX2 (X = Cl, Br, I)
Authors: Guo Jiatian , Lu Zhutong , Wang Keyu , Zhao Xiuwen , Hu Guichao , Yuan Xiaobo , Ren Junfeng 
Published: November 2021

Abstract
Inspired by the new progress in the research field of two-dimensional valleytronics materials, we propose a new class of transition metal halides, i.e. H-ZrX2 (X = Cl, Br, I), and investigated their valleytronics properties under the first-principles calculations. It harbors the spin-valley coupling at K and K′ points in the top of valence band, in which the valley spin splitting of ZrI2 can reach up to 115 meV. By carrying out the strain engineering, the valley spin splitting and Berry curvature can be effectively tuned. The long-sought valley polarization reaches up to 108 meV by doping Cr atom, which corresponds to the large Zeeman magnetic field of 778 T. Furthermore, the valley polarization in ZrX2 can be lineally adjusted or flipped by manipulating the magnetization orientation of the doped magnetic atoms. All the results demonstrate the well-founded application prospects of single-layer ZrX2, which can be considered as great candidate for the development of valleytronics and spintronics.
Force measurements near a natural frequency of a measurement system using inverse filters
Authors: Brooks S A , Brooks J D , Green M A 
Published: November 2021

Abstract
Accurate time-resolved force measurements for complex experimental systems are important for minimizing erroneous and misleading data. These measurements become difficult when a natural frequency of the system is in or near the expected frequency domain of the time-varying force being applied. In the cases where it is not possible to avoid this occurrence, the experimenter typically abandons the setup. This work presents an inverse filter method to compensate for the dynamic response of the measurement system. A two degree-of-freedom measurement system is used to obtain force measurements with dominant forcing frequencies above and below the first natural frequency of the system. The results show that inverse filtering can be used along with digital low pass filters to correct amplification and phase shift due to the dynamic response of the measurement system to within ±4.0

%

of total forcing amplitude and ±5.0∘. A simple cam follower mechanism is proposed as a method of low-frequency dynamic testing.
Enhancing the generalizability of predictive models with synergy of data and physics
Authors: Shen Yingjun , Song Zhe , Kusiak Andrew 
Published: November 2021

Abstract
Wind farms require predictive models for predictive maintenance. There is a need to predict values of non-observable parameters beyond ranges reflected in available data. A predictive model developed for one machine many not perform well for another similar machine. This is usually due to a lack of generalizability of data-driven models. To increase the generalizability of predictive models, this research integrates data mining with first-principle knowledge. Physics-based principles are combined with machine learning algorithms through feature engineering, strong rules and divide-and-conquer. The proposed synergy concept is illustrated with a wind turbine blade icing prediction and achieves significant predictive accuracy across different turbines. The proposed process should be widely accepted by wind energy predictive maintenance practitioners because of its simplicity and efficiency. Furthermore, the testing scores of KNN, CART and DNN algorithms are increased by 44.78%, 32.72% and 9.13%, respectively, with our proposed process. We demonstrate the importance of embedding physical principles within the machine learning process, and also highlight an important point that the need for more complex machine learning algorithms in industrial big data mining is often much less than it is in other applications, making it essential to incorporate physics and follow the ‘less is more’ philosophy.
An advanced electrical heating technique for double-sided Y(Gd)BCO coated conductor: gaining high engineering current density based on MOCVD
Authors: Yang Fan , Zhao Ruipeng , Tao Bowan , Chen Xi , Huang Tao , Fei Xi , Chen Tingyu , Xia Tao , Chang Yongtao 
Published: November 2021

Abstract
An advanced electrical heating technique was proposed and adopted for the reel-to-reel deposition of double-sided Gd
x
Y1−x
Ba2Cu3O7−δ
(Y(Gd)BCO) films on the surface of LaMnO3/epitaxial-MgO/IBAD-MgO/Y2O3/Al2O3/Hastelloy tapes based on the metal organic chemical vapor deposition process. In this technique, heating current is introduced into alloy tape to produce heat through the electric brushes. The use of thin Hastelloy tapes is an effective method to obtain a high engineering current density. However, the reduction of the substrate thickness will directly attenuate its mechanical strength, which will lead to the deformation of tapes at high temperature based on original electric heating device. More seriously, the electrical contact between the alloy substrate and the brush will deteriorate, which could cause ignition and ablation at the edge of the tapes. Therefore, in order to improve mechanical and electrical stability, we redesigned a novel electrical heating device to deposit Y(Gd)BCO films. Furthermore, through adopting the multiple-deposition process based on the new electrical heating device, the J
e of Y(Gd)BCO film can reach 900 A mm−2 (at self-field, 77 K), which has been significantly improved compared with the J
e before optimization.
Gaussian information bottleneck and the non-perturbative renormalization group
Authors: Kline Adam G , Palmer Stephanie E 
Published: November 2021

Abstract
The renormalization group (RG) is a class of theoretical techniques used to explain the collective physics of interacting, many-body systems. It has been suggested that the RG formalism may be useful in finding and interpreting emergent low-dimensional structure in complex systems outside of the traditional physics context, such as in biology or computer science. In such contexts, one common dimensionality-reduction framework already in use is information bottleneck (IB), in which the goal is to compress an ‘input’ signal X while maximizing its mutual information with some stochastic ‘relevance’ variable Y. IB has been applied in the vertebrate and invertebrate processing systems to characterize optimal encoding of the future motion of the external world. Other recent work has shown that the RG scheme for the dimer model could be ‘discovered’ by a neural network attempting to solve an IB-like problem. This manuscript explores whether IB and any existing formulation of RG are formally equivalent. A class of soft-cutoff non-perturbative RG techniques are defined by families of non-deterministic coarsening maps, and hence can be formally mapped onto IB, and vice versa. For concreteness, this discussion is limited entirely to Gaussian statistics (GIB), for which IB has exact, closed-form solutions. Under this constraint, GIB has a semigroup structure, in which successive transformations remain IB-optimal. Further, the RG cutoff scheme associated with GIB can be identified. Our results suggest that IB can be used to impose a notion of ‘large scale’ structure, such as biological function, on an RG procedure.
The Optimum Storage Conditions on the Quality of the Stingless bee Honey
Authors: Meechai Imron , Chelong Isma-ae , Chedoloh Romlee 
Published: November 2021

AbstractHoney of stingless bee has a higher moisture content than bees. Long-term storage may cause fermentation processes to change the physicochemical properties and taste. Thus, the aim of this research was evaluation of the optimum storage condition on the quality of stingless bee honey. Stingless bee honey (Tetragonular larviceps) was contained in plastic bottle and kept at ambient temperature (30-35°C) and low temperature (4-8°C) for 0-45 days. Before and after storage honey were analyzed the physicochemical properties and sensory investigation for comparison of quality. The results showed that temperatures and storage times have affected on the reducing sugar content, pH, conductivity, color, moisture content with significant difference (p<0.05). While, temperatures and storage times have unaffected on the °Brix value (p>0.05). Additionally, the physicochemical properties of honey were according with previously quality report. The sensory investigation indicated that the smell natural flavor, consistency, taste and sourness were not significant difference (p>0.05). In contrast, the color and overall preference were significant difference (p<0.05). For honey quality, Thus, the honey might keep at 4-35°C for ≤45 day of this study.
Porous Activated Carbon Binder-free Scleria sumatrensis Stem-Based for Supercapacitor Application
Authors: Taer Erman , Akbar Tsalis Muhammad Ali , Apriwandi  , Yanti Novi , Awitdrus  , Lazuardi  , Taslim Rika 
Published: November 2021

Abstract
Green, sustainable and effective development technique to obtain high porous activated carbon biomass based is important to boosting supercapacitor performance with environmentally friendly effect as conversion system and energy storage devices. We reported porous activated carbon binder-free Scleria sumatrensis stem-based as electrode material high performance of symmetric supercapacitor. Precursor biomass of Scleria sumatrensis stem was converted into porous carbon through simple ZnCl2 impregnated with different concentration of 0.4M, 0.5M, 0.6M, and 0.7M at high-temperature phyrolysis. All samples confirmed good amorphous carbon with small amounts of oxidative compounds. In two-electrode system, the optimum sample of ACSS0.6 significantly boosting the specific capacitance as high as 142.62 F g−1 at scan rate of 1 mV s−1. Furthermore, the optimum energy density was found to be 19.80 Wh kg−1 at a maximum power density of 71.35 W kg−1 in 1 M H2SO4 aqueous electrolyte. These results confirm that the porous activated carbon binder-free Scleria sumatrensis stem-based through simple ZnCl2 impregnated as an electrode material to boosting the electrochemical behavior of supercapacitors.
Mangifera foetida L. (Macang) Source of Potent Antiviral Activity of Against Dengue Virus Serotype 2 (Anti DENV2)
Authors: Fitmawati  , Safitri Maya , Kholifah S.N. , Emrizal  , Roza Rodesia Mustika 
Published: November 2021

AbstractThe new discovery about the potential ofMangifera foetidaL. as an antiviral will help conservation efforts in nature while maintaining and increasing its biodiversity value. This study aims to characterize the in vitro potential of three varieties ofM. foetidaL. against the dengue virus. Dengue virus is infected in Vero cells, viral replication was measured using the Viral ToxGlo Assay method. The selectivity ability ofMangifera foetidaL. stem bark extract to inhibit the dengue virus was seen from the Selectivity Index (SI) value. The standard curve between the concentration of the compound (μg/mL) and % cell viability was analyzed by linear regression using Microsoft Excel 2010 software. The results showed that the selectivity index (SI) value ofM. foetidaL stem bark extract of Limus, Manis and Batu varieties were 7.58, 6.82 and 16.43, respectively. It was concluded that the extract of Macang stem bark of the Limus, Manis and Batu varieties had the potential to be used as an antiviral for dengue.
Synthesis, in vitro Antioxidant Activity, and Toxicity Evaluation of Hydrazone Derivatives Naphthalene-1-ylmethylene hydrazine
Authors: Jasril  , Juwiyatri E , Fauza S N , Afriana N 
Published: November 2021

Abstract
Hydrazone is a versatile organic compound that has a basic structure (-NHN=CH-) called the azomethine group. This structure is responsible for the physical and chemical of hydrazone, which makes this compound has variety bioactivities such as antioxidant, antitumor, and anticancer. In this work, two hydrazone derivatives from 1-naphthaldehyde and hydrazine (phenylhydrazine/hydrazine hydrate) have been synthesized under microwave irradiation. Their antioxidant activity and toxicity were evaluated by DPPH and BSLT method, respectively. Structures of the synthesized compounds were confirmed based on spectroscopic data included UV, FTIR, HRMS, and 1H-NMR. Based on the DPPH assay, hydrazone from phenylhydrazine has strong antioxidant (IC50 28.90 μg/mL) but inactive antioxidant for hydrazine hydrate (IC50 >1000 μg/mL). However, both compounds have a high toxicity effect on Artemia Salina Leach with each LC50 1.45 and 47.20 μg/mL, hence they have the potential to be developed into anticancer drugs.