bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical cases of using coagulation factor VIII with von Willebrand factor in parturient women with type III von Willebrand disease
Authors: Куртов И.В. , Фатенкова Е.С. , Юдина Н.А. , Осадчук А.М. , Давыдкин И.Л. 
Published: February 2021

Болезнь Виллебранда (БВ) может представлять определенные трудности у рожениц с данной патологией. Приведены 2 клинических примера использования у женщин с БВ фактора VIII свертывания крови с фактором Виллебранда, показана эффективность и безопасность их применения. У одной пациентки было также показано использование фактора свертывания крови VIII с фактором Виллебранда во время экстракорпорального оплодотворения.
Von Willebrand disease presents a certain hemostatic problem among parturients. This article shows the effectiveness and safety of using coagulation factor VIII with von Willebrand factor for the prevention of bleeding in childbirth in 2 patients with type 3 von Willebrand disease. In one patient, the use of coagulation factor VIII with von Willebrand factor during in vitro fertilization was also shown.
Acquired hypoprothrombinemia in a patient with lymphoproliferative disorder in combination with lupus anticoagulant
Authors: Прасолов Н.В. , Шулутко Е.М. , Доброва Н.В. , Орел Е.Б. 
Published: February 2021

Введение: Приобретенная гипопротромбинемия, обусловленная циркуляцией волчаночного антикоагулянта (ВА), ассоциируется с высоким риском развития тяжелого кровотечения. Клинический случай: Описан случай приобретенного дефицита протромбина и фактора IX в сочетании с положительным ВА: у пациентки Н. была диагностирована лимфома из клеток маргинальной зоны, выявлен дефицит фактора II (21%) и фактора IX (27,1%), увеличение активированного частичного тромбопластинового времени, протромбинового времени и международного нормализованного отношения, обнаружены положительные маркеры антифосфолипидного синдрома, по данным тромбоэластографии — выраженная гипокоагуляция. Выполнена абдоминальная спленэктомия. Перед операцией пациентке был введен концентрат протромбинового комплекса (КПК) Уман Комплекс Д. И. в дозе 1500 МЕ. После введения КПК мы не достигли целевого значения активности факторов свертывания: фактор II увеличился до 49%, фактор IX — до 47%. Клинически оперативное вмешательство не сопровождалось
геморрагическим синдромом. Заключение: Сочетанный приобретенный дефицит протромбина и фактора IX у пациентки Н. с лимфомой при наличии ВА существенно увеличивал риск развития тяжелого интраоперационного кровотечения. Введение КПК с адекватным мониторингом гемостаза позволило избежать развития осложнений в периоперационном периоде.
Background: Acquired hypoprothrombinemia due to lupus anticoagulant presence is associated with a high risk of severe bleeding. Clinical case: The article describes the case of acquired prothrombin and factor IX defi ciency combined with a positive lupus anticoagulant (LA). The patient N. was diagnosed lymphoma from marginal zone cells. She had factor II (21%) and factor IX (27.1%) deficit, increased activated partial thromboplastin time, prothrombin time and international normalized ratio, positive markers of antiphospholipid syndrome, severe hypocoagulation according to thromboelastography. An abdominal splenectomy was performed. Before surgery, prothrombin complex concentrate (PCC) Complex DI Uman in a dose of 1500 IU was administrated. After PCC administration, we did not reach the target value of coagulation factors activity: factor II increased to 49%, factor IX — to 47%. Surgery was not associated with hemorrhagic syndrome. Conclusions: The combined acquired defi ciency of prothrombin and factor IX in patient N. with lymphoma and LA significantly increased the risk of severe intraoperative bleeding. PCC administration with adequate monitoring of hemostasis allowed to avoid the development of complications in perioperative period.
Hemorrhagic syndrome and complement system: is there a connection?
Authors: Работинский С.Е. 
Published: February 2021

Неспецифическую защиту организма от повреждений различной природы обеспечивает взаимодействие системы гемостаза, комплемента и кининов. В настоящей статье отражена попытка автора разобраться в этих взаимодействиях на основании обзора литературы, а также использования опыта работы выездной реанимационной гематологической бригады г. Москвы. Рассмотрены связи комплемент–гемостаз–кинины как с позиции контактной активации свёртывания, так и с позиции клеточной теории гемостаза. Отмечена роль фактора Хагемана как одного из связующих агентов между системой гемостаза и комплемента. В результате проведенного анализа прямая связь между системой комплемента и массивными кровотечениями найдена не была, однако отмечена связь патологии системы комплемента и системы гемостаза в патогенезе так называемых тромбогеморрагических состояний. В статье представлены такие критические состояния, как эмболия околоплодными водами, атипичный гемолитико-уремический синдром, гепарин-индуцированная тромбоцитопения 2-го типа, разобраны современные подходы к диагностике и лечению.
The interaction of hemostasis, complement and kinins provides non-specific protection of the body from damage of various nature. This review reflects the author’s attempt to understand these interactions based on literature review, as well as using the experience of the fi eld offsite hematologic service in Moscow. The relationships of complement–hemostasis–kinins had been observed from the perspective of both the contact activation of coagulation, and cellular theory of hemostasis. The role of the Hageman factor as one of the binding agents between hemostasis and complement was noted. As a result of the analysis, direct association between the complement system and massive bleeding was not found, but the connection between the pathology of the complement system and hemostasis in the pathogenesis of the so-called thrombohemorrhagic states was noted. The review presents such critical conditions as amniotic fluid embolism, atypical hemolytic-uremic syndrome, heparin-induced thrombocytopenia type 2, describes current approaches to diagnosis and treatment.
Thrombotic events in rare kinds of genetic thrombophilias
Authors: Николаева М.Г. , Момот А.П. , Мамаев А.Н. , Хорев Н.Г. , Пасман Н.М. , Вагнер Ю.Н. , Зайнулина М.С. , Фаткуллин И.Ф. , Сиразитдинова М.М. , Ясафова Н.Н. 
Published: February 2021

Цель исследования: изучить лабораторный фенотип редких мутаций Лейдена [FVL А(1961)A] и гена протромбина [FII А(20210)A] при их клинической реализации в виде тромбозов. Материалы и методы. Проведено многоцентровое проспективное наблюдательное исследование, включающее 80 носителей редких генетических форм тромбофилий: FVL А(1961)A (n = 31), FII А(20210)A (n = 10) и компаунд FII G(20210)A + FVL G(1691)A (n = 39). У всех пациентов исследована резистентность фактора Va к активированному протеину С (APC-R) по нормализованному отношению (НО) и уровень активности протромбина в плазме крови в состоянии физического здоровья и в случае эпизода тромботического события. Результаты. Определена ассоциативная связь развития тромботических событий со снижением НО при оценке APC-R как у гомозиготных носителей мутации Лейден (Ме = 0,35; 95% ДИ = 0,31–0,37 по НО), так и гетерозиготных компаундов (Ме = 0,43; 95% ДИ = 0,42–0,45 по НО). Заключение. Лабораторный мониторинг пациентов с редкими формами генетических тромбофилий позволяет выделить группу высокого тромбогенного риска, нуждающуюся в пролонгированной тромбопрофилактике.
Objectives: to study the laboratory phenotype of rare Leiden mutation [FVL A(1961)A] and the prothrombin gene mutation [FII А(20210)A] implementating clinically as thrombosis. Patients / Methods. A multicenter prospective observational study included 80 carriers of rare genetic kinds of thrombophilia: FVL A(1961)A (n = 31), prothrombin FII А(20210)A (n = 10) and the compound FII G(20210)A + FVL G(1691)A (n = 39). All patients were tested for the factor Va resistance to activated protein C (APC-R), normalized ratio (NR), and the plasma prothrombin activity (%) in healthy conditions and in the case of thrombotic event. Results. An associative
relation between the development of thrombotic events and a decrease in NR was determined when assessing APC-R, both in homozygous carriers of the Leiden mutation (Me = 0.35; 95% CI = 0.31–0.37 in NR) and heterozygous compounds (Me = 0.43; 95% СI = 0.42–0.45 in NR). Conclusions. Laboratory follow up for patients with rare kinds of genetic thrombophilias allows to identify a group at high thrombogenic risk requiring prolonged thromboprophylaxis.
ANALISIS KEMAMPUAN MULTI REPRESENTASI PESERTA DIDIK PADA MATERI USAHA DI MADRASAH ALIYAH
Authors: Murniati Rizki , Tandililing Edy , Hidayatullah Muhammad Musa Syarif 
Published: February 2021

The purpose of this study to identify student's multi-representation ability about work at MA Negeri Bengkayang. The method used is the survey method without comparative group which is descriptive correlative with research instrument in the form of descriptive test on the multi-representation ability test of five questions and multiple-choice test on the learning outcomes test often questions. the validity of the multi-representation test was 3.45 whit valid criteria and the validity of the learning outcomes test was 3.52 with valid criteria Meanwhile, the reliability of the multi-representation test was 0.516 in the sufficient category and the reliability of the learning outcomes test was 0.55 in the sufficient category. The study found that the multi-representation ability of students was low with an average percentage of 33.08%. The multi-representation ability of students with the highest percentage is in the image to symbol representation type, which is 75%, while the multi-representation ability of students with the lowest percentage is in the verbal to mathematical representation type, which is 5.19%. This study also did not found a correlation (r count 0.04 > r table 0.4848) between multi-representation ability and student's learning outcomes. The result of this study is expected to be taken into consideration in determining learning strategies.Keywords: Work, Multi-representation Ability, Learning Outcomes
From Syphilis to Autism, How the Anti-Vaccination Movement of Today is an Echo of the Past
Authors: Beaveridge Kayleigh 
Published: February 2021

Introduction: The anti-vaccination movement has led to decreased vaccination rates and increased vulnerability to vaccine-preventable diseases in the general population. In order to better understand the anti-vaccination movement of today, the anti-vaccination movement that emerged in the 19th century is examined and measured against the one observed in the 20th century.
Discussion: Though the population of the 19th and 20th centuries differ in many regards and our knowledge of vaccine and immune mechanisms are far greater; the anti-vaccination movement seen today stands on the same pillars as that of the 1800s with the sentiment of fear at its core. Though the façade of these pillars has been altered to suit the world today, both movements exploited the influence of prominent public figures, maintained false associations with dire vaccine consequences and emphasized these through the use of visual media, repetition and personal narratives. The persistence of the anti-vaccination movement lies largely in the use of personal stories which are more impactful and memorable then the statistical characteristics of scientific study.
Conclusion: The pro-vaccination movement must respond to the tactics used by the anti-vaccination movement and create accessible, understandable and equally impactful communication strategies in order to prevent the spread of misinformation and counter the efforts of the current anti-vaccination movement.
Relevance: Vaccine hesitancy was listed amongst the top 10 global health threats in 2019 by the World Health Organization. In order to shift the negative rhetoric surrounding vaccines, the anti-vaccination movement of today and its historic roots need to be understood.
Immune-Mediated Tissue Injury (Hypersensitivity Reactions)
Authors: Prud'homme Gerald J 
Published: February 2021

Hypersensitivity is synonymous with immune-mediated tissue injury. Hypersensitivity reactions occur in several forms and give rise to numerous conditions including allergies, autoimmune disease, allograft rejection, granulomatous inflammation, and a variety of acute or chronic inflammatory disorders (vasculitis, glomerulonephritis, arthritis, pneumonitis, encephalitis, etc.). While hypersensitivity is usually detrimental, in some cases it represents a normal response to a pathogen (e.g., the granulomatous inflammation of tuberculosis).
Several years ago, Gell and Coombs divided hypersensitivity states into four basic types (1), and this classification remains useful today (Table 1). Type I hypersensitivity reactions result from IgE-dependent degranulation of mast cells or basophils. Type II, or "cytotoxic" hypersensitivity, results from the binding of IgG or IgM antibodies to cell membranes or fixed tissue antigens, causing activation of the complement system. Type III, or "immune-complex" hypersensitivity, results from the formation of immune complexes that precipitate in tissues (or form in situ), also with activation of complement. Type IV, or "cell-mediated" reactions, can be subdivided into two basic types: type IV-A is synonymous with delayed-type hypersensitivity (DTH) and usually occurs in response to soluble antigens; type IV-B results from the direct killing of target cells by cytotoxic T lymphocytes (CTL). Stimulation of cells by anti-receptor autoantibodies (such as the anti-TSH receptor antibodies of Graves' disease) has been designated as type V hypersensitivity by some authors. In addition, there are syndromes caused by massive cytokine release that are not usually referred to as hypersensitivity reactions, although (in accord with the definition) they should be included in that category. Examples are anti-CD3 mAb therapy, superantigen- (superAg) induced diseases (toxic shock syndrome, scalded skin syndrome), and shock caused by endotoxins (gram negative septicemia).
Despite the occurrence of tissue injury, it should be understood that hypersensitivity mechanisms evolved as a means of fighting infectious agents. The mechanisms underlying these hypersensitivity states will be described and some clinical examples will be mentioned. In particular, the important role of cytokines, which is an area where considerable progress has occurred in recent years, will be emphasized.
Functional Status May Serve as a Predictor of CABG Surgery Outcome in the Elderly Patient
Authors: Mayer Chantal , Morin Jean-François 
Published: February 2021

Despite the growing number of elderly patients undergoing coronary artery bypass graft (CABG) surgery, no study addressing postoperative outcome from the perspective of preoperative functional status has been reported to date. The present investigation therefore undertook to determine, among elderly individuals matched for cardiac status, whether patients with poor functional status have a greater risk of mortality and morbidity following CABG surgery than those with good functional status. Retrospective preoperative and postoperative geriatric functional assessment using a standardized questionnaire was performed on 46 consecutive patients who had undergone CABG in 1994 at age 65 or older. Preoperative functional status was comprised of pre-anginal functional status (before angina limited physical activity) and anginal functional status (during which angina was a noticeable limiting factor). CABG outcome was recorded in terms of postoperative assessment of functional status, morbidity, and mortality. The results of statistical analysis revealed that both pre-anginal and anginal functional status were sensitive predictors of post-operative functional status (p < 0.005 and p < 0.001, respectively). In addition, the presence of comorbidities typically used in the screening of candidates was found to be a sensitive predictor of outcome (p < 0.02). However, the presence of comorbidities was not significantly linked to poor preoperative functional status (p > 0.05), indicating that these two predictors may screen for different elderly sub-populations at high risk for negative outcome of CABG. If confirmed by further studies of elderly patients undergoing CABG, these results suggest a new and important role for functional status as a predictor of CABG outcome in the elderly. Furthermore, these results may be useful toward the development of a reliable tool in screening for high risk of poor outcome among elderly candidates for CABG surgery.
Access to Own Dwelling through Ijarah at Islamic Banks and State-Owned Housing Scheme in Pakistan
Authors: Naseem Razi  , Rashida Zahoor  , Muhammad Asif Safdar  , Jibran Jamshed  
Published: February 2021

Purpose: Access to a safe dwelling is one of the necessities of life and an indicator to reveal the economic development of a country. In Pakistan, however, the majority of the people do not have their dwelling rather have to spend their life in renting homes or in slums. To overcome the housing shortfall, the State Bank of Pakistan has pronounced a low-cost housing scheme for the poor and the low-income segment of the society while the Islamic banking sector also offers ijarah facility to purchase or to construct own dwelling and claims to work in the objective of Islamic legal system. Therefore, this study aims to analyze critically, ijarah and state-owned low-cost housing scheme from the public insight. Design/Methodology/Approach: This research aims to utilize analytical, theoretical, and empirical methods of research rather than some combination thereof by utilizing experimental reasoning based on naturally occurring data, reports, and surveys. To evaluate ijarah and government housing scheme from public insight, a survey of 100 salaried persons has been conducted by way of the questionnaire at different companies in District Rawalpindi. Findings: This study found that Pakistan is suffering from the acute issue of lack of own dwelling. The result of the conducted survey reveals that the majority of the employed people showed more trust in the state-owned housing scheme than ijarah at Islamic banks. Those people showed their interest in the state-owned housing scheme than ijarah at Islamic banks. Implications/Originality/Value: The practical approach to ijarah at Islamic bank found in trust deficit concerning the public insight. That ijarah does not provide low-cost homes to the homeless people, hence not serving by Shari’ah. The current policy of the state provides an opportunity to ijarah to facilitate poor people by softening its terms and conditions and by way of qard-e-hasanah.
The Effect of Screen Size on Students’ Cognitive Load in Mobile Learning
Authors: Alasmari Talal 
Published: February 2021

<p>Mobile learning is becoming a crucial tool in this era of face-to-face shutdown of education, and however the whole process currently faces a significant deficiency due to the kind of cognitive load that does exist and its relation with mobile device screen display size. It is well-established that certain screen sizes are more effective than others. This study aims to investigate the effect of screen size on students’ cognitive load in mobile learning. Specifically, it investigates whether screen size has a role in cognitive role and draws a comparison to reflect on the most effective size to be used in the context of mobile learning. Other factors that might interfere in the process were also investigated which include course content, gender, age, and students' GPA to see whether they play any additional role in burdening the cognitive load when using different screen sizes. To test the effect of screen size on cognitive load, an online survey was distributed to 1,570 students of the University of Jeddah who are studying at the foundation year for the academic year of 2018-2018, particularly for eight online courses. The sample was chosen randomly, where all members of the population, 6,500 students, had equal opportunities to participate in the study. Participants were invited via e-mail by sending an invitation to participate along with the questionnaire link on the "Qualrrics" platform. This research data analysis technique used ANOVA and curve estimation. The research findings revealed that small screen display size produces the lowest cognitive load as compared with larger display screens. This study also supports the use mobile learning process and gives recommendations to the instructional designers in order to make learning experiences more effective. The results of this study suggest a proper use of screen size can improve learning from smartphones, making them equal to learning from laptops and reducing the overloaded cognitive load that may affect students' understanding and hinder retention. Hence, implications were discussed, and further research recommendations were then provided.</p>
SUPERVISI AKADEMIK UNTUK MENINGKATKAN KEMAMPUAN GURU MEMBUAT PENILAIAN SIKAP BERBASIS LITERASI DIGITAL
Authors: Saparudin Yudhi 
Published: February 2021

Pada saat ini pengembangan kompetensi sikap peserta didik merupakan hal yang bersifat urgen, dan harus mendasari kompetensi pengetahuan dan keterampilan. Namun sebagian guru belum terbiasa mengintegrasikan pengembangan kompetensi sikap ini pada saat melaksanakan pembelajaran. Kemudian sebagian guru mengalami kesulitan serta belum terbiasa untuk melakukan penilaian sikap. Penelitian ini bertujuan untuk untuk melihat kemampuan guru melakukan penilaian sikap berbasis literasi digital sebelum dan sesudah implementasi supervisi akademik menggunakan model Professional Learning Community (PLC). Metode penelitian yang digunakan adalah penelitian eksperimen satu kelompok, menggunakan rancangan penelitian one group pretest-postest. Untuk melihat signifikan pengaruh sebelum dengan sesudah implementasi model PLC, menggunakan paired samples t test. Sampel dalam penelitian ini adalah SMA YPKKP Bandung. Sumber data dalam penelitian ini adalah kepala sekolah, wakil kepala sekolah kurikulum, dan seluruh guru SMA YPKKP Bandun. Hasil penelitian menunjukkan bahwa implementasi supervisi akademik model PLC, dapat meningkatkan kemampuan guru dalam melakukan penilaian sikap berbasis literasi digital. Peningkatan tersebut signifikan dengan nilai p < 0.05. Kesimpulan dari penelitian ini, implementasi supervisi akademik menggunakan model PLC dapat diterapkan pada guru-guru SMA lainnya baik SMA negeri maupun swasta.
IMPACT OF INVASIVE ALIEN SPECIES AND GENDER
Authors: Shrestha Sajani 
Published: February 2021

Invasive Alien Species (IAS) is considered the second major cause of biodiversity loss and habitat degradation. They pose a serious threat to different ecosystems of Nepal such as agriculture, forestry, fisheries and natural systems. Invasive alien species affect people's livelihoods and human well-being.
Some species are important sources of fuel wood, fodder, timber and food products for local households and communities. Similarly, some species hold cultural, spiritual and recreational significance. In contrast, they also harm livelihoods and increase vulnerability via land encroachment and reduction in mobility or access. In some cases, they also diminish the abundance of natural resources used by households and reduce agricultural production. This results in a loss of their income and increases vulnerability. Furthermore, some invasive species have also negative implications on human health and safety. Likewise, they are responsible for reducing the cultural value of landscapes.
Invasive Alien Species are well-recognized drivers of social-ecological change. Extensive research on invasive species in Nepal has yet to be done. Therefore, the impact of invasive species on livelihoods and human well-being is a lesser-known concept. The effect of benefits and costs analysis of invasive species on livelihoods and human well-being remains pivotal for policy-making and management. This article is based on the development of a comprehensive national strategy and plan of action to control and manage IAS in Nepal. It discusses the broader aspect and status of IAS in Nepal.