bluuebunny/crossref_metadata_2025_split huggingface dataset:
KARAKTERISTIK MUTU DAN ORGANOLEPTIK PERMEN JELLY RUMPUT LAUT (Eucheuma spinosum)
Authors: Kamaluddin La Ode , Haslianti Haslianti , Sadimantara Muhammad Syukri 
Published: October 2021

ABSTRACT The aim of this study was to determine the quality and organoleptic characteristics of seaweed jelly candy (E. spinosum). This study used a Completely Randomized Design (CRD) consisting of 3 treatments: P1 = Seaweed: sucrose: water = 100 gr: 100 gr: 30 ml, P2 = Seaweed: sucrose: water = 120: 100: 30 ml, P3 = Seaweed: sucrose: water = 140 gr: 100: 30 ml: with there times replication. Data from observations were analyzed using ANOVA (Analysis of Variance) at a level of 95%, if there is a significant difference (P> 0.05) then a further test was performed with a DMRT (Duncan Multiple Range Test) tests at a 95% significance level. The results obtained showed that the concentration of seaweed (E. spinosum), sucrose, and water significantly affected the color, texture, aroma, and taste of seaweed jelly candy. The best treatment was in of P1 with a color value of 3.42 with a category like P1 texture 3.90 with a very like category, P1 aroma 3.58 with a very like category, and P1 a taste of 3.98 with a very like category. The chemical value of seaweed jelly candy is the value of water content 10.16% -13.26%, ash content 0.32-0.44%, and protein content 2.92% -4.17%. Keywords: Chemical test. Jelly candy, seaweed (Eucheuma spinosum), sensory and sucroseABSTRAKTujuan penelitian ini adalah untuk mengetahui karakteristik mutu dan organoleptik permen jelly rumput laut (E. spinosum). Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari 3 perlakuan yaitu : P1 = Rumput laut: sukrosa : air = 100 gr : 100 gr: 30 ml, P2 = Rumput laut: sukrosa : air = 120 : 100 : 30 ml, P3 = Rumput laut : sukrosa : air = 140 gr : 100 : 30 ml : dan ulangan sebanyak tiga kali. Data hasil pengamatan dianalisa menggunakan ANOVA (Analysis of Variance) pada taraf 95%, apabila terdapat beda nyata (P>0,05) maka dilakukan uji lanjut dengan uji DMRT (Duncan Multiple Range Test) pada taraf nyata 95%. Hasil penelitian yang diperoleh menunjukkan bahwa Kosentrasi rumput laut (E. spinosum), sukrosa dan air berpengaruh nyata terhadap warna, tekstur, aroma dan rasa permen jelly rumput laut. Perlakuan terbaik terdapat pada perlakuan P1 dengan nilai warna sebesar 3,42 (suka), P1 tekstur 3,90 (sangat suka), P1 aroma 3,58 (sangat suka)dan P1 rasa 3,98 (sanagt suka). Nilai kimia permen jelly rumput laut yaitu nilai kadar air berkisar 10.16%-13.26%, kadar abu berkisar 0,32-0.44% dan kadar protein berkisar 2,92%-4.17%.Kata kunci: Uji kimia, pernen jelly, rumput laut (E. spinosum), sensorik dan sukrosa
Genetically Predicted Longer Telomere Length May Reduce Risk of Hip Osteoarthritis
Authors: Yang Jing , Xu Huiqing , Cai Bingyue , Wei Jiahe , Sun Lingling , Li Yasong , Wang Tianle , Li Yingjun 
Published: October 2021

Objective: This two-sample Mendelian randomization (MR) study aimed to examine the potential causal association of telomere length (TL) with the risk of osteoarthritis (OA).Method: The summary-level data for OA was derived from the United Kingdom Biobank cohort, including 50,508 individuals of European descent. Eighteen single nucleotide polymorphisms associated with TL were identified as instrumental variables from the most up-to-date TL genome-wide association study (GWAS) involving over 78,592 individuals of European descent. Based on the GWASs data, MR was performed using established statistical analysis methods including the inverse variance weighted, weighted median, MR-Egger, and MR pleiotropy residual sum and outlier.Results: Genetically determined TL was not associated with the risk of total OA (IVW odds ratio [OR] = 1.00, 95% confidence interval [CI] = 0.83, 1.21). In subgroup analyses stratified by OA site, no evidence in favor of association between genetically determined TL and knee OA was found (IVW OR = 1.18, 95% CI = 0.89, 1.58). However, using WM method, we observed a limited protective effect of longer TL on the risk of hip OA (OR = 0.60, 95% CI = 0.36–0.99), whereas the results of the IVW (p = 0.931) and MR-PRESSO (p = 0.932) showed that TL had no effect on hip OA.Conclusions: This study does not support a causal association between TL and total OA. A potential protective association between longer TL and hip OA, though possible, remains less certain.
Attitudes to Being Vaccinated Against COVID-19: A Survey of People With Epilepsy in China
Authors: Qiao Shan , Zhang Ran-ran , Yang Ting-ting , Wang Zhi-hao , Fang Xi-qin , Fang Chun-yan , Geng Jian-hong , Zhang Dong-mei , Qu Li-xin , Cao Li-li , Han Tao , Liu Xue-wu 
Published: October 2021

Objective: We conducted a survey to assess vaccination coverage, vaccination willingness, and variables associated with vaccination hesitancy to provide evidence on coronavirus disease (COVID-19) vaccination strategies.Methods: This anonymous questionnaire study conducted a multicenter, cross-sectional survey of outpatients and inpatients with epilepsy (PWE) registered in epilepsy clinics, in 2021, in 10 hospitals in seven cities of Shandong Province.Results: A total of 600 questionnaires were distributed, and 557 valid questionnaires were returned. A total of 130 people were vaccinated against COVID-19. Among 427 unvaccinated participants, 69.32% (296/427) were willing to receive the COVID-19 vaccine in the future, and the remaining 30.68% (131/427) were unwilling to receive vaccination. Most (89.9%) of the participants believed that the role of vaccination was crucial in response to the spread of COVID-19. A significant association was found between willingness to receive the COVID-19 vaccine and the following variables: age, marital status, level of education, occupation, residence, seizure type, and seizure control after antiepileptic drug therapy. It is noteworthy that education level, living in urban areas, and seizure freedom were significantly related to willingness to receive COVID-19 vaccination.Conclusions: Vaccination is a key measure for the prevention and control of COVID-19, and most PWE are willing to be vaccinated. Vaccine safety, effectiveness, and accessibility are essential in combatting vaccine hesitation and increasing vaccination rates.
Experiment in vivo: How COVID-19 Lifestyle Modifications Affect Migraine
Authors: Grozeva Vesselina , Mínguez-Olaondo Ane , Vila-Pueyo Marta 
Published: October 2021

Introduction: The coronavirus disease 2019 (COVID-19) pandemic represents a unified lifestyle modification model, which was developed by the globally applied measures. The lockdowns designed the perfect study settings for observing the interaction between migraine and the adopted changes in lifestyle. An experiment in vivo took place unexpectedly to determine how the lockdown lifestyle modifications can influence migraine.Subsection 1: Overall lifestyle modifications during the pandemic: People stay home, and outdoor activities and public contacts are restricted. Sleep is disturbed. Media exposure and prolonged screen use are increased. Working conditions change. In-person consultations and therapies are canceled. The beneficial effects of short-term stress, together with the harmful effects of chronic stress, were observed during the pandemic.Subsection 2: Short-term effects: Substantial lifestyle changes happened, and knowing how vulnerable migraine patients are, one could hypothesize that this would have resulted in severe worsening of headache. Surprisingly, even though the impacts of changing social conditions were significant, some patients (including children) experienced a reduction in their migraine during the first lockdown.Subsection 3: Long-term effects: Unfortunately, headache frequency returned to the basal state during the second pandemic wave. The risk factors that could have led to this worsening are the long-term disruption of sleep and dietary habits, stress, anxiety, depression, non-compliance to treatment, and working during the pandemic.Discussion: Sudden short-term lifestyle changes taking migraine patients out of their usual routine may be beneficial for headache management. It is not necessary to have a natural disaster in place for a drastic lifestyle modification with 6–8-week duration, if we know that this will improve migraine.
Cerebral Blood Flow Difference Between Acute and Chronic Tinnitus Perception: A Perfusion Functional Magnetic Resonance Imaging Study
Authors: Hu Jinghua , Xu Jin-Jing , Shang Song’an , Chen Huiyou , Yin Xindao , Qi Jianwei , Wu Yuanqing 
Published: October 2021

Purpose: The central nervous mechanism of acute tinnitus is different from that of chronic tinnitus, which may be related to the difference of cerebral blood flow (CBF) perfusion in certain regions. To verify this conjecture, we used arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI) in this study to compare the CBF alterations of patients with acute and chronic tinnitus.Methods: The current study included patients with chronic tinnitus (n = 35), acute tinnitus (n = 30), and healthy controls (n = 40) who were age-, sex-, and education-matched. All participants underwent MRI scanning and then ASL images were obtained to measure CBF of the entire brain and analyze the differences between groups as well as the correlations with tinnitus characteristics.Results: The chronic tinnitus group showed increased z-CBF in the right superior temporal gyrus (STG) and superior frontal gyrus (SFG) when compared with the acute tinnitus patients. Further connectivity analysis found enhanced CBF connectivity between the right STG and fusiform gyrus (FG), the right SFG and left middle occipital gyrus (MOG), as well as the right parahippocampal gyrus (PHG). Moreover, in the chronic tinnitus group, the tinnitus handicap questionnaire (THQ) score was positively correlated with the normalized z-CBF of right STG (r = 0.440, p = 0.013).Conclusion: Our results confirmed that the CBF changes in some brain regions were different between acute and chronic tinnitus patients, which was correlated with certain tinnitus characteristics. This is of great value to further research on chronicity of tinnitus, and ASL has a promising application in the measurement of CBF.
Stress, Subordination, and Anomalies of Feeding Across the Tree of Life: Implications for Interpreting Human Eating Disorders
Authors: Natterson-Horowitz B. , Cho Julia H. 
Published: October 2021

Eating behaviors of animals living in naturalistic environments offer unique insights into several dysregulated eating patterns observed in humans. Social subordination is a known precipitant of hyperphagia and hypophagia in human beings, and examples of similar responses have been identified in a phylogenetically widespread range of vertebral species. This points to potentially conserved, patterned responses to animals navigating lives within social hierarchies. Self-imposed food restriction in subordinate fish and hyperphagic responses in socially subordinated bird and primate individuals may represent evolved adaptations to the stress of social subordination. As such, hyperphagic and hypophagic responses to social subordination in these species may model the natural history, neurobiology, and behavioral ecology of human dieting and bingeing more accurately than some current animal models.Phylogenetically widespread similarities in eating patterns under the stress of social subordination point to potentially shared biological benefits of these behaviors across species and the role of evolutionary trade-offs, adaptations, and other processes in shaping them. The application of a broadly comparative lens to disordered eating behaviors in other species exposes important similarities and differences between neurophysiology of eating across species. In doing so, it highlights the value of phylogenetic analyses and macroevolution as tools for identifying novel, naturally occurring models for understanding disordered human eating. Moreover, this approach introduces the intriguing possibility that human cultural influences on disordered eating may have far more ancient origins than previously considered.
Impact of MicroRNAs in Interaction With Environmental Factors on Autism Spectrum Disorder: An Exploratory Pilot Study
Authors: Cui LiHua , Du WenRan , Xu Ning , Dong JingYi , Xia BingJie , Ma JingYi , Yan RuoTong , Wang LanYing , Feng FuMin 
Published: October 2021

Background: This study aimed to explore the main effects of environmental risk factors as well as their interaction effects with miRNA on the risk of autism spectrum disorder (ASD).Methods: One hundred fifty-nine ASD children (ASD group) and 159 healthy children (control group), aged 2–6 years, were included in this study. ASD diagnoses were based on DSM-5 criteria. The extensive medical and demographic characterization of the two groups were recorded. MicroRNAs (miRNAs) in serum were detected by qRT-PCR.Results: Compared with the control group, the ASD group had significantly higher rates of maternal stress during pregnancy (p &lt; 0.001), maternal drinking during pregnancy (p = 0.006), threatened abortion (p = 0.011), pregnancy-induced hypertension (p = 0.032), gestational diabetes (p = 0.039), maternal anemia during pregnancy (p &lt; 0.001), umbilical cord knot (p &lt; 0.001), neonatal jaundice (p &lt; 0.001), family psychiatric history (p = 0.001), and much lower birth weight (p = 0.012). Furthermore, the ASD group had much lower expression levels of hsa-miR-181b-5p (p &lt; 0.001) and hsa-miR-320a (p &lt; 0.001) and significantly higher levels of hsa-miR-19b-3p (p &lt; 0.001). The interactions of hsa-miR-320a and maternal stress during pregnancy (OR = 39.42, p &lt; 0.001), hsa-miR-19b-3p and neonatal jaundice (OR = 2.44, p &lt; 0.001), and hsa-miR-181b-5p and family psychiatric history (OR = 8.65, p = 0.001) could increase ASD risk.Conclusions: The dysregulation of hsa-miR-181b-5p, hsa-miR-320a, and hsa-miR-19b-3p could interact with environmental factors, such as maternal stress during pregnancy, neonatal jaundice, and family psychiatric history, to impact the risk of ASD.
Viabilidade econômica de microgeradores eólicos para residências unifamiliares / Economic feasibility of wind microgenerators for single-family residences
Authors: De Oliveira Uriel Wizniewsky , Francescatto Matheus Binotto , Roos Cristiano 
Published: October 2021

No Brasil, a utilização da energia eólica vem crescendo e sua participação aumentando na diversificação da matriz energética. Ela se mostra uma das principais fontes de energia limpa e sustentável. Porém, a maioria dos projetos e produtos no mercado têm ênfase em geração eólica com potência elevada, o que requer muito investimento. Tendo isso em vista, o objetivo deste trabalho é realizar uma análise técnica e econômica da utilização de microgeradores eólicos grid tie comerciais para atender a demanda energética de uma residência unifamiliar na cidade de Santa Vitória do Palmar, no Rio Grande do Sul, utilizando dados atuais e reais de taxas e encargos. Na elaboração deste trabalho foram simulados 16 cenários com diferentes tipos de aerogeradores de acordo com o sistema de bandeiras tarifárias vigente da ANEEL. Para a análise econômica, foram utilizados os métodos de Valor Presente Líquido, Taxa Interna de Retorno, Payback Simples e Payback Descontado, juntamente com a metodologia LCOE para comparar a relação custo-eficácia dos geradores. Para a análise técnica foi levado em consideração as velocidades mínima, nominal e máxima de cada aerogerador, bem como a potência e a energia elétrica gerada a partir da curva de potência, a demanda energética da residência, a distribuição de probabilidade de Weibull, a velocidade e a direção dos ventos na cidade. Em conclusão, este trabalho alcançou seus objetivos mostrando seis cenários viáveis técnica e economicamente, sendo quatro cenários ideais, com uma residência de maior consumo, e dois cenários reais.
Análise de ações através de indicadores contábeis: o caso da empresa duratex s.a. na bolsa de valores / Analysis of actions through accounting indicators: the company's case duratex s.a. on the stock exchange
Authors: Pires Wagner Santana , Pacheco Fernando 
Published: October 2021

Os investidores do mercado de ações possuem variadas formas de análise para escolha das ações, porém é importante conhecer as características deste mercado e da empresa em que irão investir. O objetivo deste estudo é analisar as ações da empresa DURATEX S.A. na bolsa de valores com base nos indicadores contábeis do período estudado. Os procedimentos metodológicos envolvem pesquisa analítica e descritiva, mediante a isso, através da análise fundamentalista com o uso de demonstrativos contábeis, se tem a análise de indicadores de rentabilidade que demonstram a saúde financeira da empresa, podendo ser usada para fazer uma previsão de resultados futuros e consequentemente retorno financeiro aos investidores. Neste estudo é apresentado uma análise fundamentalista da empresa DURATEX S.A. acompanhando a variação de preço das ações na bolsa de valores após decisões e mudanças administrativas internas no período de 01 de janeiro de 2019 até 30 de setembro de 2020. Essa análise, denominada de fundamentalista, é uma ferramenta que auxilia na tomada de decisão do investidor, quando este tem a intensão de negociar papéis no mercado de ações ou selecionar empresas para formar uma carteira de investimentos. No Brasil, as ações (menor parte acionária de uma empresa de capital aberto) são negociadas na bolsa de valores (B3). Este estudo foi fundamentado a partir de dados que são disponibilizados pelas próprias empresas em seus websites. Os indicadores que foram utilizados para realização da análise fundamentalista neste estudo foram os seguintes: ROE, VPA, P/VPA, DP, DY, LPA e PSR. Assim, a conclusão após as análise dos indicadores das ações da empresa estudada indicam que é uma boa opção de investimento para longo prazo.
Redução do tempo de produção em uma indústria farmacêutica / Production time reduction in a pharmaceutical industry
Authors: Oliveira Felipe Escolaro , De Lima Erick Rodrigo , Do Vale Rosilda do Rocio 
Published: October 2021

O presente estudo é uma pesquisa de campo, realizado em uma empresa do ramo farmacêutico, a qual está localizada na cidade de São José dos Pinhais no estado do Paraná, e teve como objetivo reduzir o tempo de produção e atender a meta estipulada pela empresa que é de 40 minutos. Para a coleta de dados foi realizada uma entrevista informal com o gerente logístico, a observação participativa realizada por um dos autores que trabalha na empresa, pesquisa documental em documentos fornecidos pela empresa e brainstorming entre os autores e a equipe de logística e de produção, foram identificadas doze causas, sendo que cinco foram priorizadas utilizando a Matriz GUT. Para buscar alternativas de soluções para elaborar o plano de ação foi realizado o benchmarking em uma empresa do ramo logístico, brainstorming entre os autores e equipe de logística e produção e pesquisa em artigo científico e foi utilizado o 5W2H para elaborar o plano de ação. Das seis ações apresentadas, já foi atualizado os critérios da cronoanálise, adquirida uma paleteira semi automática, substituidos os documentos manuais do procedimento de controle de qualidade para planilhas eletrônicas e foi contratado um colaborador para o setor de compras. Porém as ações reorganizar o layout do armazém e elaborar um fluxo de compra simplificado, estão prevista para serem implantadas em 2021. Com a implantação dessas quatro ações o tempo médio de produção reduziu de 53 minutos para 20 minutos, apresentando um ganho de 33 minutos o que correspode a 62% e ficando 50% abaixo da meta definida pela empresa que é 40 minutos.
Psychological Impact of COVID-19 Pandemic on Pregnant Women
Authors: Sultana Rashida , Fatima Anees 
Published: October 2021

Background: Covid-19 pandemic has spread throughout the world in a short period of time. It has adversely affected the physical, mental and social well-being of communities including pregnant women. This study is aimed to determine the frequency, severity and associated factors of depression, anxiety and stress among pregnant women during COVID-19 pandemic.
Material and Methods: This cross-sectional study was conducted in Sharif Medical City Hospital, Lahore, from August to September 2020.Data was obtained on structured proforma comprised of two sections. Section one consisted of sociodemographic and obstetric components while second two was based on Urdu Version of DASS-21. Data was analyzed using SPSS-23.
Results: Total number of women was 350. Their mean age was 27.47 ± 4.72 while mean duration of their pregnancy was 26.33±9.17weeks. Mean DASS-21 score of depression, anxiety, and stress was 8.00±2.89, 5.80±3.10 and 9.18±2.80 respectively. It was observed that depression was present in 123(35.1%) ranging from mild to moderate, anxiety in 127(36.3%) ranging from mild to very severe and stress in only 20(5.7%) women and was mild.
Education was significantly associated with all three domains. The women who were infected themselves or any other family member affected with COVID-19 showed positive association for depression (p=0.00) and stress (p=0.00). Stress was higher in young age groups (p=0.04) and in women with higher monthly income (p=0.00) while parity also showed association with anxiety (p=001). Anxiety and depression were more in house wives (p=0.00) while stress in working women (p=0.00).
Conclusion: Frequency of depression and anxiety was notable varying from mild to very severe however for stress it was low and mild. Educational level was significantly associated with depression, anxiety, and stress.
Use of n-type amorphous silicon films as an electron transport layer in the perovskite solar cells
Authors: Song Zhancheng , Sumai Yuuka , Tu Huynh Thi Cam , Shahiduzzaman Md. , Taima Tetsuya , Ohdaira Keisuke 
Published: October 2021

Abstract
We have investigated the use of n-type amorphous silicon (n-a-Si) films as the electron transport layers (ETL) in perovskite (PVK) solar cells, aiming at the application to PVK/Si tandem solar cells. The use of n-a-Si as the ETL in MAPbI3 PVK solar cells was attempted, and the power conversion efficiency (PCE) of fluorine-doped tin oxide- (FTO-) based solar cells was improved due to an improvement in coverage on FTO with thicker n-a-Si, but the external quantum efficiency in the short wavelength region was decreased due to parasitic absorption of n-a-Si. The use of indium tin oxide with a flat surface resulted in a PCE of 1.25% for the solar cells with 10 nm-thick n-a-Si. This work indicates that n-a-Si is a potential ETL candidate for PVK solar cells and provides strategic guidance for the future vacuum-integrated process of PVK/Si heterojunction tandem solar cells, which can be feasible for efficient mass production.