bluuebunny/crossref_metadata_2025_split huggingface dataset:
ДО ПРОБЛЕМИ ФОРМУВАННЯ МОНОЛОГІЧНОГО МОВЛЕННЯ УЧНІВ ПОЧАТКОВИХ КЛАСІВ ЗАСОБАМИ МЕДІАОСВІТИ
Authors: Сіранчук Наталія 
Published: December 2024

У статті експериментально доведено ефективний вплив медіаосвіти на формування монологічного мовлення учнів початкових класів. Встановлено недостатність ігрового україномовного медіаосвітнього контенту для дітей молодшого шкільного віку у вільному доступі.
Визначено ефективні форми провадження медіаосвіти на уроці, в позакласній діяльності та в школі продовженого дня. Запропоновано найбільш ефективні прийоми формування монологічного мовлення учнів початкових класів засобами медіаосвіти: сприймання літературно-художніх образів, емоційно-усвідомлений аналіз літературних творів, робота над розумінням виразності літературних структур.
Встановлено, що функціювання постійно діючого шкільного медіаколективу та You Tube каналу школи позитивно впливає на формування монологічного мовлення учнів початкової школи. З’ясовано, що для ефективного формування монологічного мовлення, важливого значення набуває виконання учнями лексико-граматичних вправ (освітній медіаконтент школи), які уможливлять свідоме використання граматичних форм в процесі мовленнєвої творчості.
Практика навчання учнів у школах Києва засвідчила важливість широкого використання тематики учнівських монологів: враження від зустрічей з письменниками, героями війни; складання літературно-музичних композицій, нарисів про місцевих героїв, наших сучасників та ін.
PRELIMINARY STUDY ON FORMULATION OF PVA-BASED FACE MASK INCORPORATED WITH SUGARCANE BAGASSE MICROFIBRILLATED CELLULOSE
Authors: Jimat Dzun Noraini , Mohamad Istisyhad , Amid Azura , Azmi Azlin Suhaida , Abd. Wahab Mohd Firdaus 
Published: December 2024

Bio cellulose facial masks have gained a huge interest in the cosmetic industry. The raw materials such as plant biomass, bacteria and algae have been used as producers of cellulose. In this study, several formulated facial masks (F1,F2,F3,F4 and F5) incorporated with nanocellulose extracted from sugarcane bagasse (SCB) have been prepared. Polyvinyl alcohol (PVA) and nanocellulose of sugarcane bagasse (NC-SCB) concentrations were varied to get appropriate composition of the facial masks. The nanocellulose was extracted through chemical treatment assisted with ultrasonication. The physicochemical characteristics of the formulated facial masks in terms of appearance and drying time as well as its organoleptic characteristics; adhesion to skin, spreadability, colour and odour were evaluated. Spectral analysis of the best formulation (F3) and standard formulation of facial mask with sodium carboxymethyl cellulose (CMC) (F6) were compared to observe their chemical structural changes. The results showed that the formulated facial mask, F3 has better performance in term of drying time and adhesion to skin when compared to standard formulation using sodium carboxymethyl cellulose (CMC). This proves that the presence of nanocellulose of sugarcane bagasse showed competitive performance with the standard formulation of facial mask.
CARBON CAPTURE AND STORAGE WITH LIPID PRODUCTION IN INTEGRATED SYSTEM OF AQUEOUS AMMONIA WITH MARINE MUTANT SYNECHOCOCCUS PCC 7002 IIUM01
Authors: Azmi Azlin Suhaida , Awan Mohamed Anwar , Amid Azura , Mohamad Puad Noor Illi , Ali Fathilah 
Published: December 2024

Carbon capture and storage (CCS) involve capturing, transporting and storing CO2 underground geological permanently. Carbon capture using solvent such as amine and aqueous ammonia has been extensively studied by many researchers. However, this capture technology for CCS scheme is comparatively costly. Alternatively, CO2 emission can be captured and stored by utilizing the well-understood natural photosynthetic process of marine cyanobacteria. However, the capturing process is very slow compared to chemical absorption. Hence, this study concentrates on carbon capturing and storing using integrated of aqueous ammonia and mutated marine cyanobacteria (Synechococcus PCC 7002 IIUM01). The objective of the study was to identify conditions that would maximize CO2 reduction under varying conditions namely CO2 flow rate, absorption temperature and aqueous ammonia concentrations. The effectiveness of the mutant cyanobacteria was quantified by measuring the cell concentration, percentage reduction in carbon dioxide concentration, and lipid content. Synechococcus PCC 7002 IIUM01 showed it robustness by growing in aqueous ammonia solution at concentration between 0.5 to 1%(w/v) which the parent strain was not able to tolerate. The best conditions maximizing CO2 capture and storage while sustaining growth optimally and being a potential biofuel source was 0.5 Lpm of 15% CO2 gas flow rate, 0.75% (w/v) of ammonia concentration and at 33oC of optimum temperature. At this condition, around 68% of CO2 removal was achieved with 9% yield of lipid and more than 13% (w/v) of cell concentration
EFFECTS OF DAIDZIN AND ANALOGUE OF GANODERMA SINENSE ON BACTERIALLY-EXPRESSED HUMAN HEXOKINASE ISOFORM 2 FOR ANTI-DENGUE DRUG DESIGN
Authors: Nur Atikah Asman  , Suriyea Tanbin  , Ahmad Fuad Fazia Adyani 
Published: December 2024

Dengue disease, which is caused by dengue virus (DENV) has been a major worldwide concern, with increased number of cases each year. Currently, there are no specific medications to treat the disease. Hence, there is a dire need to develop novel drugs for disease treatment. Glycolysis is a metabolic pathway that serves as the main source of energy for DENV replication and targeting the pathway is one of the ideal approach to discover new anti-DENV drugs. This paper focuses on the inhibition of the human hexokinase isoform 2 (HK2) enzyme, which is one of the important enzymes in glycolysis, in the quest to disrupt DENV replication. In order to search for potential inhibitors, two methods were conducted, which are ligand-based screening and structure-based screening approaches. The docking of Daidzin, which was derived from Kudzu, a Japanese plant, has shown the nearest binding affinity score (-7.94 kcal/mol) to Glucose‘s (GLC), which is -8.15 kcal/mol. Meanwhile, from the ligand-based screening, Ethyl (2R)-2-[[3-[2-[(4-methylbenzoyl)amino]ethyl]-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]sulfanyl]butanoate, a compound which is the analogue of Ganoderma sinense with a binding score of -8.43 kcal/mol was chosen for the subsequent inhibition studies. These compounds were further analysed in an inhibition assay to determine the effects of of the potential naturally-derived inhibitors on the activity of HK2. The outcome from the inhibition study shows that both compounds exhibited substantial inhibition on HK2 enzyme, where Daidzin, at 0.5 mM, resulted in HK2 remaining activity of 88.98%, while Ethyl (2R)-2-[[3-[2-[(4-methylbenzoyl)amino]ethyl]-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]sulfanyl]butanoate (Ethyl (2R)) resulted in 69.58% of HK2 remaining activity, also at 0.5 mM concentration. In conclusion, this study has served as a platform for the development of anti-dengue drugs based on naturally-derived compounds, which is anticipated to be a safer option for dengue treatment
SURFACE FUNCTIONALIZATION OF MESOPOROUS HOLLOW CARBON NANOPARTICLES USING UV/OZONE TREATMENT
Authors: Muhammad Nur Amir Azman  , Ahmad Nor Yusilawati , Samsudin Nurhusna , Ma’an Fahmi Rashid Alkhatib  , Tshai Kim Yeow  
Published: December 2024

Carbon nanoparticles have been widely used in various applications. However, they are commonly known to have low dispersibility and chemical inertness which limit their practicallability in medical or biological area. Some studies have been performed to modified carbon nanoparticles such as carbon nanotubes using UV-Ozone system. However, little is known on the effect of such system towards other types of carbon nanoparticles such as mesoporous hollow carbon nanoparticles (MHCNs). Thus in this study, improvement of MHCNs physiochemical properties have been studied using UV-Ozone treatment for the first time. The treatment was conducted in water as dispersant agent at ozone flowrate of 1.0 L/min and exposure time of 45 min. SEM images observed that MHCNs morphology and surface structure remain intact after the treatment. Observations on the dispersibility of MHCNs in phosphate buffered saline (PBS) solution shows that the dispersibility was improved compared to the untreated ones. This was supported by the low Z-average and PDI values of treated MHCNs obtained at ~400 nm and 0.2 respectively when compared to untreated MHCNs which obtained at 970 d.nm and 0.417 respectively. Thermogalvimetric analysis (TGA) also shows an increased in weight loss of treated MHCNs at lower temperature compared to untreated ones. Results from fourier transform infrared (FTIR) shows an increased number of new functional groups that include carboxylic acid group presence at surface of treated MHCNs which contributed to the improvement of their dispersibility, thermal properties and chemical functionality. These findings opened a new possibility of using UV/Ozone treatment to improve physicochemical properties of MHCNs for medical area such as in drug delivery application in addition to their excellent drug storage and carrier system.
AGARWOOD BRANCH ETHANOLIC EXTRACT: OPTIMAL EXTRACTION PROCESS CONDITIONS AND CYTOTOXIC EFFECTS
Authors: Abbas Phirdaous , Hashim Yumi Zuhanis Has-Yun , Mohd Salleh Hamzah , Syed Abdul Azzizz Saripah Salbiah 
Published: December 2024

Uninfected agarwood branch is readily available as raw material in agarwood plantation as new practices of agarwood plantation scheme were opted as substitute to the endangered wild type agarwood. The uninfected branch can be easily obtained during pruning process (one of plantation’s common maintenance procedure), throughout the years before inoculation stage. This current study aimed to investigate the optimal extraction process conditions of agarwood branch using ethanol as solvent system for maximal yield, and assess its cytotoxic effects towards MCF-7 breast cancer cells. Uninfected branch of Aquilaria subintegra was subjected to One Factor at a Time (OFAT) and Response Surface Methodology (RSM)-guided ethanolic extraction to achieve maximal yield. The extract was then subjected to cytotoxicity, cell attachment and cell viability assays, respectively. Optimization Run 2 (temperature 45 °C, solid-liquid ratio of 1:30, 16 hours maceration) gave the highest agarwood branch ethanolic extract (ABEE) yield of 44.70 ± 18.9 mg/g dried material (DM). Meanwhile Run 7 (temperature 45 °C, solid-liquid ratio of 1:10, 16 hours of maceration) gave the lowest yield (19.34 ± 14.1 mg/g DM). However, while maintaining the 16 hour-maceration, the model predicted a slightly lower yield of 30.232 ± 0.266 mg/g DM of ABEE with process conditions of 45 °C and solid-liquid ratio of 1:19 when the desirable parameters were factored in namely using (i) the most suitable temperature (that does not risk the bioactivities of the extract), and (ii) an economical volume of solvent. Crude ABEE obtained from the optimal process conditions resulted in cytotoxicity effects on MCF-7 breast cancer cells with IC50 estimate of 3.645 ± 0.099 µg/mL. The extract also affected MCF-7 cell attachment and viability with altered morphology. More work to elucidate the mechanism of actions of the extract are warranted; which could further lead to development of breast cancer natural product-based therapeutics.
COMPARATIVE STUDY ON ORGANIC AND INORGANIC FERTILIZERS AND THEIR EFFECTS ON GROWTH AND YIELD OF TOMATO AND CUCUMBER UNDER GREENHOUSE CONDITIONS
Authors: Mohamed Rania E. , Lubna Mohamed Musa Mohamed  , Abdelmalik Eltayeb. M 
Published: December 2024

Organic fertilizers are derived mainly from animal matter, human excreta or crop residues, while chemical fertilizers are defined as any inorganic material of wholly or partially synthetic origin, that is added to the soil to sustain plant growth. This study was designed to compare between a commercial organic fertilizer and chemical fertilizers and their effects on growth and yield of tomato and cucumber under greenhouse conditions . The experiment was conducted in the cropping season of 2016/2017 at the University of Gezira. The experiment consist of four treatments viz. control , inorganic fertilizers, organic fertilizers (commercial organic fertilizer, Elkhaseeb ,of only cow manure) and a combination between organic and inorganic fertilizers. The soil of the experimental site is a riverain silt loam soil .The experiment for the two vegetable crops was arranged in a split plot design with three replications, and two factors, commercial organic fertilizer (OM) and chemical fertilizers (MN) which include nitrogen in the form of urea and phosphorus in the form of triple superphosphate. Foliar fertilization of micronutrients with Ca and B, was used for all treatments. Commercial organic fertilizer: OM was added at the rate of 15 tons /ha and nitrogen was added as urea at 86 kg/ha (2N) . Phosphorus was applied as triple superphosphate at 43 kg P2O5/ha (1P). Tomato seedlings of cultivar Termis were transplanted on the ninth of February,2017 whereas cucumber seeds, variety Leader were planted on the first of February,2017.The results showed that the effect of combination of inorganic fertilizers and organic fertilizers is significantly higher than application of either fertilizer alone. The combination resulted in 417.65 kg /ha of tomatoes and 823.53 kg / ha of cucumber. Application of the commercial organic fertilizer alone gave 261.4kg / ha in tomatoes, while in cucumber it gave732.03 kg /ha. Inorganic fertilizers alone gave 256.84 kg/ha in tomatoes and 447.7kg/ha in cucumber. This lead to a recommendation that application of combined fertilizers (organic+ inorganic) is the best practice for tomato and cucumber under greenhouse conditions, than any of the two fertilizers alone.
FUNCTIONAL CHARACTERIZATION OF PUTATIVE LATE ELONGATED HYPOCOTYL (LHY) GENE IN Stevia rebaudiana MS007 via IN SILICO ANALYSIS
Authors: Samsulrizal Nurul Hidayah , Abdul Rahim Zabirah , Mohamad Nazar Siti Noor Eliana , Mustafa Nur Farhana 
Published: December 2024

Stevia rebaudiana is a medicinal herb that has been known as a low-calorie sweetener. It has been recognised as an artificial sweetener that is 300 times sweeter than sucrose. It is a commercially important sweetener that has been consumed as food and medicine due to its ability to reduce blood sugar levels. Stevioside is one of the important compounds that give food a sweet taste. Previous studies showed a high amount of stevioside could be produced by delaying the flowering process of stevia. The aim of this study is to isolate and characterise the putative Late Elongated Hypocotyl (LHY) gene that is involved in the flowering process by using bioinformatics tools. Both analysis by using BLAST and domain search found that LHY gene involved in flowering process. These domains are SANT/Myb domain (IPR001005/SM000717), TEA domain (SM00426), Myb domain (IPR017930), and Myb domain plants (IPR006447). The phylogenetic tree was built using 20 out of 100 protein sequences from BLAST. The physico-chemical properties of putative LHY protein had been conducted through ProtParam and TMHMM showed the protein is globular protein. The phylogenetic tree construction indicated the common ancestor for the putative LHY protein, which is from the same family, i.e., Asteraceae. In summary, this study improves our knowledge of the Stevia MS007 LHY gene by in-silico analysis. Therefore, future research should focus on determining the precise function of the protein in regulating the blooming stage of the stevia plant.
ИНФОРМАТИКА МҰҒАЛІМДЕРІНІҢ ӘДІСТЕМЕЛІК ҚҰЗЫРЕТТІЛІГІН ҚАЛЫПТАСТЫРУДА ЦИФРЛЫҚ ТЕХНОЛОГИЯЛАРДЫҢ ӘЛЕУЕТІН ПАЙДАЛАНУ
Authors: Абдрашова Э.Т. , Кемелбекова Ж.С. , Веряев А.А. 
Published: December 2024

Мақалада білім берудің цифрлық трансформациясы жағдайындағы информатика мұғалімдерінің әдістемелік құзыреттілігін қалыптастырудың мәселелері қарастырылады. Қазіргі таңда цифрлық құзыреттілік пен цифрлық сауаттылықты талдау және бағалау - жоғары білім беру мекемелерінің оқытушылары үшін алдыңғы қатарға шығып отыр. Заманауи цифрлық технологияларды игеру үшін оқытушы мыналарды қалыптастыруы керек: әртүрлі цифрлық құралдармен, электрондық ресурстармен жұмыс істеу қабілеті, өмірдегі және болашақтағы кәсіби білім берудегі цифрлық қызметтерінің қабілеті. Дегенмен, цифрлық технологияларды қолданудың тәжірибесі білім беру процесінде білім алушыны әдістемелік сүйемелдеу және цифрлық білім беру ресурстарының қажеттілігі міндетті болып табылады. Бұл зерттеудің басты мақсаты болашақ информатика мұғалімдерінің әдістемелік құзыреттілігін қалыптастырудың тиімді әдісі ретінде – цифрлық білім беру ресурстарының маңызын айқындау болып табылады. Зерттеу барысында тeopиялық және эмпиpикaлық әдіcтep қолданылды. Яғни білім алушылардың оқу үдерісіндегі оқу қызметін бақылау, оқытушылардың тәжірибесін зерделеу, оқытушылар мен білім алушылар арасында тәжірибелік-эксперименттік әңгіме жүргізу, сауалнама жүргізу, білім алушылардың орындаған жұмыстарын талдау, бағалау.
Зерттеу нәтижесінде информатика педагогтарының цифрлық технологияларды игеруі барысында педагогикалық дағдылары, талаптары мен құзыреттерінің жаңа мүмкіндіктері ашылды. Цифрлық технологиялар арқылы болашақ информатика пәні мұғалімінің әдістемелік құзыреттілігін қалыптастыру моделін анықтау мақсатында болашақ информатика пәні мұғалімінің әдістемелік құзыреттілігін қалыптастыру деңгейлері мен диагностикалық құралдары әзірленді. Болашақ информатика мұғалімдерінің кәсіби бағдарын қалыптастырудағы білімді цифрландыру үдерісінің маңызы айқындалды.
THE ROLE OF ARTIFICIAL INTELLIGENCE IN THE FORMATION OF COMMUNICATIVE COMPETENCE IN FOREIGN LANGUAGE LESSONS
Authors: Zhumatayeva Z.N. , Mametkarim Zh.M. , Dosanova A.M. 
Published: December 2024

This article discusses the role of artificial intelligence (AI) in the development of intercultural communicative competence (ICC) in the context of foreign language acquisition. In modern education, communicative competence has become very important because it requires the use of a foreign language for communication. Communicative competence, as an individual's ability to communicate effectively, is of particular importance in modern society. The purpose of the article is to analyze the current application AI in foreign language teaching, examine its impact on developing speaking, writing, listening skills and communicative competences of learners. The findings demonstrate AI's ability to personalize learning experiences, hence increasing learner autonomy and engagement. The first section identifies the theoretical foundations of ICC and explores the potential of AI-driven tools to enhance communicative skills. It outlines the methodological approaches used to analyze AI`S role and highlights its benefits in creating interactive learning process. The second section provides a comparative analysis of traditional and AI-enhances teaching methods, illustrating how AI improves skill acquisition through real-time simulations and adaptive feedback mechanisms. Challenges related to data privacy, algorithmic biases, and access inequalities are also discussed.
The paper concludes with recommendations for using artificial intelligence into language teaching while maintaining ethical, inclusive, and sustainable methods. The main goal of the article is to ensure the development of communicative skills and to investigate how these skills can be developed in the educational process using artificial intelligence.
ҚАЗАҚСТАНДА ИНФЛЯЦИЯНЫҢ АРТУЫ ЖӘНЕ ОНЫ ТӨМЕНДЕТУДІҢ ӨЗЕКТІ ЖОЛДАРЫ
Authors: Иманбаев А.А. , Балабекова Д.Б. , Куралбаев А. 
Published: December 2024

Бұл мақалада Қазақстанда инфляция деңгейінің өсу себептеріне талдау жасалып және оның алдын алу шаралары бойынша ұсыныстар берілді. Өкінішке орай, Қазақстан Республикасында инфляциялық өсім тоқтар емес, өткен жылдың тиісінші айымен салыстырғанда, 2024 жылдың қазанында инфляция деңгейінің 8,5% өсімі тіркелді. Мұнда ең қажеттілерін атап өтсек, ақылы қызметтердің бағасы бір жылда 14,3%–ға, азық–түлік емес тауарлардың бағасы 7,8%–ға, азық-түлік тауарларының бағасы 4,9%-ға өсіп отырғандығын көреміз.
Инфляцияға қарсы шаралар бағытында ҚР Үкіметі тарапынан мемлекеттік шығындар мен трансферттерді бюджеттік реттеу ұтымды нәтижелерге әкелмей жатыр, сондықтанда біз үшін бұл инфляция деңгейінің өсу мәселесі жылдан жылға өзекті. Қазақстандағы инфляция өсімін көптеген жылдар бойына зерттеме сараласақ, жылдан жылға инфляция қарқынды өсіп жатырғандығын, сондай-ақ ел экономикамыздың дамуы тұрақсыздыққа тән екендігін байқаймыз. Үкімет пен Ұлттық Банк бұл инфляция деңгейінің өсу мәселесін үнемі атап, тұтынушылық тауарлар бағаларын тұрақтандыру және төмендету бойынша көптеген жоспарлар мен кешенді іс-шаралар жүргізіп жатырғанымен, қажетті нәтижелер мен жетістіктерге жете алмай жатырғандығының куәсіміз. Мақаламызда біз, елдегі жоғары өсімге ие инфляцияның негізгі себептеріне сараптама жүргіземіз, сонымен қатар басқарушы билік органдарының қабылдап жатырған кешенді іс-шараларының неге оң нәтижелерге әкелмей жатырғандығын талдаймыз.
Зерттеу барысында төмендегідей нәтижелерге қол жеткізілді:
- Қазақстан экономикасының дамуына теріс әсер етуші инфляциялық үдерістердің зияндықтары сараланды;
- Қазақстанда қаржы және валюта нарығы жеткіліксіз дамығандығы анықталды;
- Қазақстанның экономикасының жоғары деңгейде шикізатқа тәуелділігі және соның негізінде сыртқы байланыстардың дұрыс еместігі зерттелді;
- инфляция деңгейінің өсуін тежеуде экономиканы әртараптандыру басымдықтары ұсынылды;
- өндіріс ошақтарын көптеп ашылуына ықпал жасау бағытындағы мемлекетіміздің қағазбастылық тұрпаттағы кешенді іс-шаралардан көрі, нақты өндірісті индустриялау реформаларын қайта жасау қажеттіктері ұсынылады.
Studi di DKI Jakarta: Peran Karakteristik Pasien Dewasa dengan Keberhasilan Pengobatan Tuberkulosis Paru
Authors: Salsabila Atikah , Sudarto Ronoatmodjo  
Published: December 2024

Latar belakang: Berdasarkan capaian tahun 2022 angka keberhasilan pengobatan kasus Tb di Provinsi DKI Jakarta tahun 2022 sebesar 81%, yang mana angka ini belum memenuhi sasaran nasional sebesar 90% maupun capaian nasional sebesar 85.9%.Tujuan: untuk mengetahui faktor paling dominan yang berhubungan dengan keberhasilan pengobatan Tb di Provinsi DKI Jakarta tahun 2022. Metode: penelitian ini menggunakan desain studi Cross-sectional. Permintaan data SITB tahun 2022 kepada Dinas Kesehatan Provinsi DKI Jakarta dilakukan pada bulan Mei tahun 2024, sedangkan penelitian ini dilakukan pada bulan Juni-September 2024. Sampel diambil secara total sampling dari populasi eligible yang memenuhi kriteria inklusi dan eksklusi. Kriteria inklusi adalah pasien Tb paru dewasa berusia 19-59 tahun yang memiliki hasil akhir pengobatan sedangkan kriteria eksklusi adalah data hilang atau tidak lengkap, sehingga total pasien yang diteliti yaitu 29.723 kasus. Hasil: keberhasilan pengobatan Tb di Provinsi Jakarta tahun 2022 adalah sebesar 80.5%.Terdapat hubungan yang signifikan antara jenis kelamin perempuan (aPR; 1.305, 95% CI; 1.16-1.47), kelompok usia dewasa (aPR; 1.29, 95% CI; 1.151-1.46), terdiagnosis klinis (aPR; 1.51, 95% CI; 1.38-1.69), dan sumber obat (aPR; 2.16, 95% CI; 1.32-3.54) dengan keberhasilan pengobatan Tb di Provinsi DKI Jakarta tahun 2022. Kesimpulan: sumber obat menjadi faktor yang memiliki nilai prevalens ratio (PR) paling besar terhadap keberhasilan pengobatan