Statins and SARS‐CoV‐2 Infection: Results of a Population‐Based Prospective Cohort Study of 469 749 Adults From 2 Canadian Provinces
Authors: McAlister Finlay A. , Wang Ting , Wang Xuesong , Chu Anna , Goodman Shaun G. , van Diepen Sean , Jackevicius Cynthia A. , Kaul Padma , Udell Jacob , Ko Dennis T. , Kwong Jeffrey C. , Austin Peter C. , Lee Douglas S. , Abdel‐Qadir Husam , de Mestral Charles , Goodwin Shaun , Ha Andrew , Kapral Moira , Kwong Jeff , Rochon Paula , Roifman Idan , Ross Heather , Schull Michael , Sun Louise , Wang Bo , Wijeysundera Harindra , Yu Amy , Bainey Kevin , Bakal Jeff , Ezekowitz Justin , Greiner Russ , Kalmady Sunil , Welsh Robert , Westerhout Cindy , Liu Peter , Sandhu Roopinder 
Published: October 2021

Background
Small observational studies have suggested that statin users have a lower risk of dying with COVID‐19. We tested this hypothesis in a large, population‐based cohort of adults in 2 of Canada’s most populous provinces: Ontario and Alberta.

Methods and Results

We examined reverse transcriptase–polymerase chain reaction swab positivity rates for SARS‐CoV‐2 in adults using statins compared with nonusers. In patients with SARS‐CoV‐2 infection, we compared 30‐day risk of all‐cause emergency department visit, hospitalization, intensive care unit admission, or death in statin users versus nonusers, adjusting for baseline differences in demographics, clinical comorbidities, and prior health care use, as well as propensity for statin use. Between January and June 2020, 2.4% of 226 142 tested individuals aged 18 to 65 years, 2.7% of 88 387 people aged 66 to 75 years, and 4.1% of 154 950 people older than 75 years had a positive reverse transcriptase–polymerase chain reaction swab for SARS‐CoV‐2. Compared with 353 878 nonusers, the 115 871 statin users were more likely to test positive for SARS‐CoV‐2 (3.6% versus 2.8%,
P
<0.001), but this difference was not significant after adjustment for baseline differences and propensity for statin use in each age stratum (adjusted odds ratio 1.00 [95% CI, 0.88–1.14], 1.00 [0.91–1.09], and 1.06 [0.82–1.38], respectively). In individuals younger than 75 years with SARS‐CoV‐2 infection, statin users were more likely to visit an emergency department, be hospitalized, be admitted to the intensive care unit, or to die of any cause within 30 days of their positive swab result than nonusers, but none of these associations were significant after multivariable adjustment. In individuals older than 75 years with SARS‐CoV‐2, statin users were more likely to visit an emergency department (28.2% versus 17.9%, adjusted odds ratio 1.41 [1.23–1.61]) or be hospitalized (32.7% versus 21.9%, adjusted odds ratio 1.19 [1.05–1.36]), but were less likely to die (26.9% versus 31.3%, adjusted odds ratio 0.76 [0.67–0.86]) of any cause within 30 days of their positive swab result than nonusers.

Conclusions
Compared with statin nonusers, patients taking statins exhibit the same risk of testing positive for SARS‐CoV‐2 and those younger than 75 years exhibit similar outcomes within 30 days of a positive test. Patients older than 75 years with a positive SARS‐CoV‐2 test and who were taking statins had more emergency department visits and hospitalizations, but exhibited lower 30‐day all‐cause mortality risk.