bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complications of the Early Neonatal Period in Children from Mothers with Gestational Diabetes Mellitus
Authors: Orazmuradov Agamurad , Bekbaeva Irina , Arakelyan Gayane , Minaeva Anastasia , Akhmatova Anastasiya , Haddad Khalid , Suleymanova1 Zhasmin , Kyrtikov Sergey , Zokirova Nozimabonu , Aleksey A. Lukaev Aleksey 
Published: December 2021

Background: Changes in the course of gestational diabetes mellitus (GDM) at the present stage determine the emergence of a certain spectrum of completely new problems associated with the health status of newborns from mothers with GDM. The aim of the study was to investigate early neonatal complications in newborns from mothers with GDM.	Methods and Results: The study included 404 pregnant women (gestational age of 37.0–41.0 weeks) with GDM. All patients with GDM were divided into 2 groups. Group 1 included 188 patients receiving insulin therapy; Group 2 included 216 patients receiving a well-balanced diet. The control group (Group 3) consisted of 68 pregnant women without disorders of carbohydrate metabolism. In Group 1, macrosomia occurred in 44(23.4%) newborns, in Group 2 - in 48(22.0%) newborns; in newborns from mothers of the control group, the frequency of macrosomia was only in 7.35% of newborns (P=0.01). Morpho-functional immaturity of newborns had the highest frequency of occurrence, despite the fact that all children were born on time; 80(42.6%) newborns from mothers of Group 1 and 77(35.6%) newborns from mothers of Group 2 had signs of morpho-functional immaturity.	Conclusion: Diabetic fetopathy in newborns from mothers with GDM is manifested by morpho-functional immaturity of organs and systems developing in unfavorable hyperglycemic conditions.
Modern Clinical and Epidemiological Features and New Technological Possibilities in the Treatment of Bleeding Gastroduodenal Ulcers
Authors: Barannikov Sergey , Cherednikov Evgeniy , Yuzefovich Igor S. Yuzefovich , Banin Igor , Polubkova Galina , Vysotskaya Anastasiya , Maleev Yuri , Ovsyannikov Evgeniy , Chernykh Aleksandr 
Published: December 2021

The aim of this research was to study the current clinical and epidemiological features of ulcerative gastroduodenal bleeding (GDB) and to evaluate the outcomes of using new technological approaches in patients with bleeding from acute (symptomatic) and chronic (peptic ulcer disease) gastroduodenal ulcers (GDUs).	Methods and Results: The present study involved 221 patients with bleeding GDUs. Depending on the source of bleeding, all patients were divided into 2 groups. Group 1 included 143 patients with acute symptomatic GDUs; Group 2 consisted of 78 patients with peptic ulcer disease complicated by bleeding. In the complex treatment of patients of all the studied groups, an individual approach was used that included the innovative technologies of endoscopic cytoprotective treatment of GDB, based on the combined use of traditional means of EH in combination with the use of endoscopic pneumoinsufflation of biologically active drainage sorbent of a new generation Aseptisorb-D and powdered hemostatic Zhelplastan. Our analysis showed that acute symptomatic GDUs prevailed in the structure of GDB – 143(64.7%) patients; PUD complicated by bleeding was diagnosed in 78(35.3%) cases. The use of new technological approaches, including cytoprotective treatment of bleeding defects with biologically active draining sorbents of a new generation in combination with local hemostatics in the complex therapy of patients with ulcerative GDB, has significantly improved the results of treatment, which is confirmed by high rates of final hemostasis (95.0%), indicators of the effectiveness of primary EH in type FIA-IB (93.1%) and prevention of recurrence of FIIA-IIB bleeding (92.5%), with a low frequency of repeated bleeding (4.07%), emergency surgeries (2.7%), and mortality (3.2%).	Conclusion: Currently, in the structure of ulcerative GDB, acute symptomatic GDUs are the most common – 64.7%, and the share of PUD complicated by bleeding accounts for 35.3% of cases only. PUD and GDUs complicated by bleeding have certain clinical and epidemiological features, which must be taken into account when treating these patients. Symptomatic GDUs are more difficult to treat, which shows the need to develop new complex technologies for their treatment.
A Novel Approach for Near Wellbore Stimulation and Deposits Removal Utilizing Thermochemical Reaction
Authors: Alharith Abdullah , Albassam Sulaiman , Al-Zahrani Thamer 
Published: December 2021

Abstract
Organic and inorganic deposits play a major issue and concern in the wellbore of oil wells. This paper discusses the utilization of a new and novel approach utilizing a thermochemical recipe that shows a successful impact on both organic and inorganic deposits, as an elimination agent, and functions as stimulation fluid to improve the permeability of the near wellbore formation.
The new recipe consists of mixing nitrite salt with sulfamic acid in the wellbore at the target zone. The product of this reaction includes heat, acidic salt, and nitrogen gas. The heat of the reaction is enough to liquefy the organic deposits, and the acidic salt will tackle the carbonate scale in the tube and will increase the permeability of the near wellbore area. The nitrogen gas is an inert gas; it will not affect the reaction and will help to flow back the well after the treatment.
The experimental work shows an increment in the temperature by 65 °C when mixing the two chemicals. The test was conducted at room conditions and the temperature reached around 90 °C. Adding another 65 °C to the wellbore temperature is enough to melt asphaltene and wax, the acidic salt tackles carbonate scale. As a result, the mixture works on eliminating both the organic and inorganic deposits. The permeability of the limestone sample shows an increment of 65% when treated by the mixture of the reaction recipe.
The uniqueness of the new thermochemical recipe is the potential of performing three objectives at the same time; the heat of the reaction removes the organic deposits in the wellbore, the acidic salt tackles carbonate scale, and improves the permeability of the near wellbore zone.
Characterization of Oil Well Cement Performance during Early Hydration under Simulated Borehole Conditions
Authors: Li Z. , Vandenbossche J. M. , Iannacchione A. T. , Vuotto A. 
Published: December 2021

Summary
Experiments on oil well cement (OWC) slurries were performed using the newly developed laboratory-scale wellbore simulation chamber (WSC). The WSC can simulate hydrostatic pressure reduction in the cemented annulus and possible gas migration under representative conditions. Forensic analysis shows that pressurized fluids can result in porous cement and gas channeling during cement slurry gelation. The effects of different factors on slurry pore pressure were also studied, including formation permeability, initial overburden pressure (OBP) representing the depth of interest, wellbore temperature, water/cement (w/c) ratio, cement composition, and the use of a calcium chloride (CaCl2)-based accelerator. By analyzing the temperature history of hydrating cement using degree of hydration, the evolution of cement hydration was characterized for slurry designs cured at different hydration rates. This provides the opportunity to parameterize the slurry designs and other important factors associated with wellbore conditions.
The PROactive Cohort Study: Rationale, Design, and Study Procedures
Authors: Vlist Merel. M Nap-van der , Hoefnagels Johanna W. , Dalmeijer Geertje W. , Moopen Neha , Ent van der Cornelis K. , Swart Joost F. , de Elise M. Putte van , Nijhof Sanne L. 
Published: December 2021

Abstract
Children with a chronic condition face more obstacles than their healthy peers, which may impact their physical, social-emotional, and cognitive development. The PROactive cohort study identifies children with a chronic disease at high risk of debilitating fatigue, decreased daily life participation and psychosocial problems, as well as children who are resilient and thrive despite the challenges of growing up with a chronic condition. Both groups will teach us how we can best support children, adolescents and parents to adapt to and manage a disease, as well as tailor interventions to their specific needs. This cohort follows a continuous longitudinal design. It is based at the Wilhelmina Children's Hospital (WKZ) in the Netherlands and has been running since December 2016. Children with a chronic condition (e.g. cystic fibrosis, juvenile idiopathic arthritis, chronic kidney disease, or congenital heart disease) as well children with medically unexplained fatigue or pain in a broad age range (2-18 years) are included, as well as their parent(s). Data are collected from parents (of children between 2-18 years) and children (8-18 years), as well as data from their electronic health record (EHR). Primary outcome measures are fatigue, daily life participation, and psychosocial well-being, all assessed via patient- and proxy-reported outcome measures. Generic biological/lifestyle, psychological, and social factors were assessed using clinical assessment tools and questionnaires. In the PROactive cohort study the research assessment is an integrated part of clinical care. Children are included when they visit the outpatient clinic and are followed up annually.
Elderly´s Malnutrition, Processes/health Outcomes in Primary Health Care: A Scoping Review
Authors: Taveira Adriana Sofia , Sousa Bárbara , Costa Patrício , Macedo Ana Paula 
Published: December 2021

Abstract
Objectives - The aim of this study, as the first review directed at Primary Health Care, is identifying screening/intervention tools/health outcomes that validate malnutrition in the elderly. Methods - Following PRISMA, searches were conducted in 4 electronic databases on observational, qualitative, quantitative, or mixed studies, written in Portuguese, Spanish or English language, with participants aged 65 years or older. Results - 483 studies were identified, 16 were considered eligible. The Mini Nutritional Assessment showed the highest criteria of choice, however, health systems do not demonstrate standardized practices in the screening´s use. Studies are more oriented towards the relationship´s analysis of mortality/morbidity and malnutrition than its effects on the person´s quality of life. Discussion - Malnutrition is one of the modifiable factors and contributes to the frail elderly condition, with serious effects, especially when related to other comorbidities. Yet, several authors argue that Primary Health Care intervention can improve health outcomes.
Phylogenetic Analysis And Searching Bovine Papillomaviruses In Teat Papillomatosis Cases In Cattle By Histopathological, Immunohistochemical And Transmission Electron Microscopy Methods
Authors: Yıldırım Yakup , Kale Mehmet , Özmen Özlem , Çağırgan Abdurrahman Anıl , Hasırcıoğlu Sibel , Küçük Ali , Usta Ayşegül , Sökel Sevinç 
Published: December 2021

Abstract
Papillomaviruses are epitheliotropic viruses causing proliferations in skin, mucosa and various internal organs in different animal species. Especially due to lesions it causes in teats of cattle, it leads to important economical losses in milk sector. In this study, the aim was to diagnose bovine papillomaviruses (BPVs) causing teat papillomas in cattle by immunohistochemical, transmission electron microscopy (TEM) and molecular methods and to detect the defect on tissues by the virus using histopathological method. In addition to this, sequence analysis of the isolated field strains were to be carried out and their genetic and phylogenetic closeness with the strains within the literature were to be detected. After confirming teat papillomatosis in the collected samples using histopathological and immunohistochemical methods, other diagnosis methods were then used. During the TEM examination of teat lesions, intranuclear virus particles were seen in epithelium cells. After carrying out PCR using degenerate primers and type specific primers, 7 samples were detected as positive for BPV and these samples were used for typing using sequence analysis/PCR with type-specific primers. Within these analysis, three out of seven BPV isolates we collected from infected teat tissues of different cattle were detected as BPV-6, two as BPV-10, one as BPV-2 and one as BPV-8. Five isolates we isolated during sequence analysis of positive samples were found in Xipapillomavirus 1 genus, one in Epsilonpapillomavirus 1 genus and another in Deltapapillomavirus genus. As a result, in molecular diagnosis of BPV that takes place in etiology of teat papillomas, using type specific primers proved to be useful following the usage of genotyping in molecular diagnosis of BPV and generate primers in characterization. Detecting BPV types and their prevalence, taking biosafety measures in animal breeding and giving importance to vaccine studies was considered essential.
PTEBL Teaching Method Combined with Caesar (Trauma Patient Simulator) Versus Traditional Teaching Method in The Training of Outstanding Doctoral Candidates in STB Skills: A Randomized Controlled Trial
Authors: Chen Shuangyi , Li Jinfei , DiNenna Michael A. , Gao Chen , Chen Shijie , Wu Song , Tang Xiaohong , He Jinshen 
Published: December 2021

Abstract
Background: The “Stop The Bleed” (STB) campaign has achieved remarkable results since it launched in 2016, but there is no report on the application of a STB course combined with a trauma patient simulator. This study proposes the “problem-, team-, and evidence-based learning” (PTEBL) teaching method combined with Caesar (trauma patient simulator) based on the STB course, and compares its effect with the traditional teaching method in outstanding doctoral candidates training of hemostasis skills.Method: Seventy-eight outstanding doctoral candidates program students (five-years and eight-years) were selected as the research subjects and were randomly divided into a control group (traditional teaching method, n=34) and an experimental group (PTEBL teaching method combined with Caesar, n=44). Their confidence of hemostasis skills and willingness to rescue were investigated before and after the course in both groups.Result: Students’ self-confidence of STB skills and willingness to rescue in both groups were improved after the class. Compared with the control group, students in the experimental group were more confident in compressing with bandages and compressing with a tourniquet after a class (compressing with bandages: control group 3.9±0.8 vs. experimental group 4.3±0.7, P=0.014; compressing with a tourniquet: control group 3.9±0.4 vs. experimental group 4.5±0.8, P=0.001) More students in the experimental group than the control group thought that the use of Caesar for scenario simulation could improve learning (control group 55.9% vs. experimental group 81.8%, P=0.024), and showed higher teacher-student interaction (control group 85.3% vs. experimental group 97.7%, P=0.042) The overall effectiveness of the teaching was better in the experimental group than the control group (control group 85.3% vs. experimental group 97.7%, P=0.042). There was a significant positive correlation between teacher-students interaction and overall effectiveness of teaching (R=1.000; 95%CI, 1.000-1.000; P<0.001).Conclusion: The PTEBL teaching method combined with Caesar can effectively improve students' mastery of STB skills, and overcome the shortcomings of traditional teaching methods, which has a certain promotional value in the training of outstanding doctoral candidates in STB skills.
Histological Origin and Clinicopathological Analysis of Primary Ovarian Neuroendocrine Neoplasms
Authors: Shi Yuxiang , Li Li , Fan Luyao , Huang Zheng , Xie Yonghui , Hongfeng Zhang 
Published: December 2021

Abstract
Purpose

To investigate the histological origin and clinical and pathological features of primary ovarian neuroendocrine neoplasms.
Methods

We retrospectively analyzed nine cases of ovarian neuroendocrine neoplasms diagnosed at our hospital from January 2009 to January 2021.
Results

The mean age of the nine patients was 44.9 ± 15.2 years (range, 28–68 years). Six cases manifested ovarian carcinoid cancer, and the pathological types were insular and trabecular carcinoid; microscopic observation showed that the carcinoid components were limited and that stromal reaction was slight. Four cases showed teratomas, with the carcinoid components not displaying adjacent mucinous glands; and the other cases exhibited carcinoid cancer as the only tumor component, without adjacent or migratory epithelial components. The six patients were followed up for 76.6 ± 41.2 (6–123) months after resection, without disease. Two cases manifested adenocarcinoma admixed with neuroendocrine carcinoma, and the intermigration of neuroendocrine carcinoma and adenocarcinoma components could be observed; and one case was an isolated small cell neuroendocrine carcinoma with no epithelial proximity or migration observed. Adenocarcinoma admixed with neuroendocrine carcinoma and small-cell neuroendocrine carcinoma exhibited an obviously promoted interstitial reaction and damaging infiltration: these three patients underwent radical surgery supplemented by postoperative radiotherapy and chemotherapy, and follow-up lasted 34.6 ± 24.2 (7–52) months; two patients died and one showed recurrence.
Conclusions

Ovarian neuroendocrine neoplasms may reflect multiple tissue origins, carcinoid and simple neuroendocrine neoplasms with no adjacent, transitional epithelium, and may originate from original/transformed neuroendocrine cells or stem cells of the ovarian stroma. In addition, the adenocarcinoma admixed with neuroendocrine carcinoma may originate from dedifferentiated epithelium. The prognosis with carcinoid cancer is favorable, while the prognosis for neuroendocrine carcinoma is poor.
Adsorption and Reduction from Modified Polypyrrole Enhance Electrokinetic Remediation of Hexavalent Chromium-Contaminated Soil
Authors: Wang Jiangyuan , Yu Qiu , Zheng Yi , Li Jing , Jiao Binquan , Li Dongwei 
Published: December 2021

Abstract
Heavy metal pollutant Cr(Ⅵ) in the environment will pose a severe threat to animal and human health. In this work, Fe3O4@PPy, Arg@PPy, and Arg/Fe3O4@PPy were prepared to enhance adsorption of Cr(Ⅵ) by doping Fe3O4 nanoparticles and amino radicals into the original PPy structure. Their characteristics were investigated by FTIR, SEM, EDS, BET analysis, and batch adsorption experiments. And they were used as permeable reaction barriers (PRB) to combine with electrokinetic remediation (EKR) to remediate Cr-contaminated soil. Adsorption experiment results showed that the maximum adsorption capacities of PPy, Fe3O4@PPy, Arg@PPy, and Arg/Fe3O4@PPy for Cr(Ⅵ) were 60.43 mg/g, 67.12 mg/g, 159.86 mg/g, and 141.50 mg/g, respectively. All of them followed the kinetic pseudo-second-order model and the Langmuir isothermal model with a monolayer adsorption behavior. In EKR/PRB system, the presence of Fe3O4@PPy, Arg@PPy, and Arg/Fe3O4@PPy obtained the higher Cr(Ⅵ) removal efficiency near the anode than that of the PPy, increasing by 74.60%, 26.04%, 68.64%, respectively. A strong electrostatic attraction between anion contaminants and protonated modified PPy and a reduction from Cr(Ⅵ) to Cr(Ⅲ) appeared in the EKR remediation process under acid conditions. This study opened up a prospect for applying modified PPy composites to treat heavy metal contaminated soil.
Contribution of Soil Physical Propreties in The Assessment of Flood Risks in Tropical Areas. Case of The Mbo Plain
Authors: FENGUIA Sylvie Noelle DJUKEM , Nkouathio David Guimolaire 
Published: December 2021

Abstract
Flooding occurs when water is in excess and can no longer be evacuated normally. The nature of the soil has been identified as one of the major causes of flooding, hence this study aimed is to show the influence of the physico-chemical properties of the soil on the recurrence of flooding in the Mbo plain. Four soil profiles were carried out on the alluviums according to the altitudes. These profiles were described and undisturbed soil samples were taken. Then, measurements of the infiltration rate of water in the soil by the Porchet method were carried out in sixteen sites. Finally, soil samples taken by auger and core sampling were studied in the laboratory. Physico-chemical parameters such as grain size, porosity, moisture, pH, compactness and organic matter were determined. Infiltration tests carried out in situ using the Porchet method revealed a hydraulic conductivity between 10−5 and 10−7 m/s, characteristic of a semi-permeable soil. This low value of permeability results from the morpho-structural arrangement and the chemical composition of the soils of the plain. These soils are hydromorphic, which means that they are constantly flooded and temporarily waterlogged. They are more or less sandy-clay on the surface, and very clayey at depth, generally from 25 cm. The very clayey soils at the base considerably slow down infiltration and act as a real barrier layer that prevents water from infiltrating, resulting to intense runoff. These soils are very porous and compact with a fairly high water content of up to 71%. This work allows us to conclude on the role of intrinsic soil properties on the genesis of floods in lowland areas. As in many plains in Africa and in the world, the nature of the soil in the Mbo plain is a natural predisposing factor to flood risks. The methods used can be applied in areas with the same characteristics as the Mbo Plain.
Lactic Acid Metabolism And Transporter Related Three Genes Predict The Prognosis of Patients With Clear Cell Renal Cell Carcinoma
Authors: Guo Tuanjie , Zhang Jian , Wang Tao , Yuan Zhihao , Tang Heting , Zhang Dongliang , Zhang Encheng , Chen Siteng , Wang Xiang 
Published: December 2021

Abstract
Background: Lactic acid was previously considered a waste product of glycolysis, and has now become a key metabolite for cancer development, maintenance and metastasis. So far, numerous studies have confirmed that tumor lactic acid levels are associated with increased metastasis, tumor recurrence and poor prognosis. However, the prognostic value of lactic acid metabolism and transporter related genes in patients with clear cell renal cell carcinoma has not been explored.Results: We selected lactic acid metabolism and transporter related twenty-one genes for LASSO cox regression analysis in the E-MTAB-1980 cohort, and finally screened three genes (PNKD, SLC16A8, SLC5A8) to construct a clinical prognostic model for patients with clear cell renal cell carcinoma. Based on the prognostic model we constructed, the over survival (hazard ratio = 4.117, 95% CI: 1.810 - 9.362, p < 0.0001) of patients in the high-risk group and the low-risk group in the training set E-MTAB-1980 cohort had significant differences, and similar results (hazard ratio = 1.909, 95% CI: 1.414 - 2.579 p < 0.0001) were also observed in the validation set TGCA cohort. Subsequently, survival prediction was carried out based on the survival prognosis model we constructed. In the E-MTAB-1980 cohort, the area under ROC curve (AUC) of 1-, 3- and 5- years was 0.71, 0.72, and 0.77, respectively. The AUC of 1-, 3- and 5- years in TCGA cohort was 0.65, 0.65, and 0.63, respectively. Using CIBERSORT algorithm to analyze the differences in immune cell infiltration in different risk groups, we found that dendritic cells and CD4+ memory cells in the high-risk group were significantly lower than those in the low-risk group, while Treg cells were higher than in the low-risk group. Finally, through gene enrichment analysis, we found that the signal pathway that is strongly related to the prognostic model is the cell cycle. Conclusions: We constructed a prognostic model using lactic acid metabolism and transporter related genes, which can accurately predict the prognosis of patients. The poor prognosis of the high-risk group may be related to the regulation of cell cycle by lactic acid metabolism.