bluuebunny/crossref_metadata_2025_split huggingface dataset:
Konsep Diri Pustakawan Berprestasi Terbaik Tingkat Nasional Tahun 2017-2019
Authors: Meilinda Viska , Erza Elfitri Kurnia 
Published: July 2021

Konsep diri merupakan suatu pemahaman dalam diri, melalui pandangan dan perasaan tentang diri yang timbul akibat interaksi dengan orang lain. Penelitian ini bertujuan untuk mengetahui konsep diri pustakawan berprestasi terbaik tingkat Nasional tahun 2017-2019 adanya keyakinan melalui pandangan dan penghargaan terhadap perasaan seseorang mengenai dirinya. Peningkatan terhadap kepribadian diri melalui personal branding dan brand awareness yang menjadi kepercayaan diri untuk menggapai apa yang diinginkan. Metode Penelitian. Jenis penelitian kualitatif dengan metode eksplorasi. Pengambilan sampel menggunakan purposive sampling dan sampel yang digunakan sebanyak 10 informan dari populasi penelitian, yaitu pemenang pustakawan berprestasi terbaik tahun 2017-2019. Teknik pengumpulan data melalui: wawancara terstruktur dan studi dokumentasi. Teknik analisis data, yaitu reduksi data, penyajian dan penarikan kesimpulan. Hasil dan Pembahasan. Beberapa hasil penelitian menunjukkan: 1) Pustakawan mempunyai konsep diri dari adanya pengalaman di perguruan tinggi, memiliki hobi membaca buku di perpustakaan 2) Mengembangkan diri dari kepercayaan yang dilalui dengan aktif ikut asosiasi dan pelatihan pustakawan sesuai bidang 3) Terbentuknya brand awareness yang menjadi dukungan untuk berkomitmen, menujukkan ide dan aliran dari perilaku untuk mengembangkan kualitas profesionalisme.
Invertebrate hydrobiont fauna transformation in the Dombrovskyi pit lake during the period of 2014-2018
Authors:   Institute of Ecology of the Carpathians, NAS of Ukraine, Mykitchak T. , Kozlovskyy V. ,   Institute of Ecology of the Carpathians, NAS of Ukraine, Mateleshko O. ,   Uzhhorod National University
Published: July 2021

The aquatic invertebrate community of Dombrovskyi pit lake was investigated during 2014–2018. 25 species were recorded there. The only permanent component of plankton in the community is rotifer Brachionus plicatilis Müller, 1786; of benthos and neuston is hemipteran Sigara lateralis (Leach, 1817), beetle Hydrobius fuscipes (Linnaeus, 1758), flies Aedes sp., Ochlerotatus lepidonotus (Edwards, 1920), Culicoides salinarius Kieffer, 1914, Ephydra glauca Meigen, 1830 are permanent components of benthos and neuston. The main diversity of invertebrates is concentrated in littoral zone up to 2 m of depth. This is primarily due to the desalination of these areas by surface runoff. Over the last decade the mineralization of the surface water layer has decreased from 120–138 to 25–28 g/l. Combined with the desalination of water, the increase of species diversity of aquatic invertebrates was noticed in spring seasons (from 7 to 17 taxa). The freshwater taxa, which are not tolerant even to low water salinity, appeared in the community in 2018 (7–25 % of the species diversity), among them Hydrometra stagnorum (Linnaeus, 1758), Rhyacophila tristis Pictet, 1834, Coelambus impressopunctatus (Schaller, 1783), Enochrus coarctatus (Gredler, 1863), Hydrophilus caraboides (Linnaeus, 1758). The role of freshwater taxa, which are tolerant to low water salinity (up to 5 g/l), increased from 0–10 % of the species diversity in 2014–2015 to 22–35 % in 2018. Among them Eucyclops serrulatus (Fischer, 1851), Candona sp., Cypris pubera O. F. Müller, 1776, Cloeon dipterum (Linnaeus, 1760), Libellula depressa Linnaeus, 1758, Sympecta fusca Vander Linden, 1820, Paracorixa concinna (Fieber, 1848) was noted in 2018 for the first time. On the contrary, the number of saltwater taxa decreased from 20–29 % (2014–2015) to 5–14 % (2018). The saltwater aquatic invertebrate community of this pit lake has transformed into brakish-freshwater one over time. 83 % taxa of aquatic invertebrate communities from freshwater puddles near reservoir coast are noted in the Dombrovska reservoir. The introduction of species from protective canals of the reservoir is unlikely, as only 5 % of taxa from there are marked in it. The main way of the forming communities of invertebrates in this reservoir is the periodical flooding of freshwater coastal puddles.
Genotypic diversity and live weight in the populations of the Chukchi breed reindeer
Authors: Brizgalov G. , Ignatovich L. 
Published: July 2021

Purpose: study of associations of live weight and genotypic traits in reindeer populations.Materials and methods. The studies were carried out in 2018-2020. on the basis of 8 agricultural enterprises in Chukotka. Tissue samples (ear pinch) of deer of different sex and age groups served as material for genetic studies. In molecular genetic studies, 1002 samples were used. Individual genotyping of animals was carried out using the ISSR-PCR method. The live weight of the reindeer was determined using the materials of the zootechnical reports of the reindeer farms. Associations of the average population indices of genetic diversity and live weight of deer were established by a calculation-statistical method of comparing the values of values. The correlation coefficient was calculated by the product method according to the Pearson formula.Results. The variability of ISSR markers in populations indicates a significant similarity between them in most of the allelic frequencies, which confirms the common origin, economic and breeding use of the Chukchi breed deer. The populations are characterized by a high degree of heterogeneity. Differences in live weight between highly productive and less productive populations on average for all sex and age groups of deer amounted to 16.8%. At the same time, the populations with a high live weight of deer significantly exceeded the populations with a lower live weight in the average number of alleles per locus by 5.0% (P <0.01), the number of effective effective alleles - by 11.8% (P <0.001), polymorphic information content index (PIC) - by 35.8% (P <0.01). The homozygosity coefficient in the low-productive animals was 12.6% higher than in the high-productive group. In the populations with the highest live weight of deer - WZR, WAE and AMG, the most significant indicators of genetic diversity were also found: the average number of alleles per locus is 8.57; 10.45 and 8.71; effective alleles per locus - 7.57; 9.10 & 8.15; expected heterozygosity - 0.868; 0.890 & 0.877; PIC index - 0.248; 0.380 and 0.374, respectively. In populations with a low live weight of deer - OST and CHN, the smallest values of the number of active effective alleles per locus were found - 6.68 and 6.41; expected heterozygosity - 0.850 and 0.844, PIC index (proportion of heterozygotes) - 0.151 and 0.254. The correlation coefficient between the indicator of live weight and the genetic diversity of deer turned out to be equal for the average number of alleles per locus r = 0.335; the number of effective alleles - r = 0.52; heterozygosity - r = 0.558, the proportion of heterozygous variants - r = 0.646.Conclusion. The data obtained make it possible to state the existence of a dependence of the live weight of deer on the genotypic diversity in the populations of the Chukchi breed.
Efficacy of Tamsulosin and Alfuzosin in Management of Distal Ureteral Stones
Authors: Piya Bimochan , Bhattarai Abhishek 
Published: July 2021

Introduction: Urinary tract calculi are the most frequent condition in urology clinics worldwide. The overall prevalence is about 5 % and lower urinary tract stones account for 70% among them. Medical expulsive therapy has been used to treat distal ureteric stone as it reduces symptoms and facilitates stone expulsion. The aim of this study is to evaluate and compare the efficacy of tamsulosin and alfuzosin as medical therapy in ureteric stones.
Materials and Methods: A total of 87 patients with distal ureteral stones of size ≤10 mm were randomly divided into 3 groups. Group A patients (n-30) received 0.4 mg of tamsulosin daily, group B patients (n-29) received 10 mg of alfuzosin daily and group C patients (n-28) received 75 mg of diclofenac sodium. Patients in all groups received diclofenac sodium for one week and then as required. Follow-up was done on a weekly basis for 4 weeks. The stone expulsion rate, time for stone expulsion, and side-effects were recorded in each group.
Results: The mean stone size (5.66, 5.79, 5.67) mm and age (29.1, 30.31, 29.4) were comparable in each group. The stone expulsion rate was 83.3%, 79.3%, and 50% in groups A, B, and C respectively. It showed that both the study groups (Group A and Group B) were effective than the control group (p-value 0.006 and 0.02 respectively) but there was no difference between tamsulosin and alfuzosin (p-value 0.69). The duration of stone expulsion was 11.5 days, 11.8 days, and 17.3 days for Group A, B, and C respectively. The drugs related side effects reported by patients were mild and transient.
Conclusion: The use of tamsulosin and alfuzosin for the medical treatment of ureteric stones proved to be safe and effective and neither did have any significant benefits over the other.
A Comparison of Incidence of Post Dural Puncture Headache Using 25G Quincke and 25G Whitacre Needle in Obstetric Patients Undergoing Caesarean Section under Spinal Anesthesia
Authors: Bohara Chetan , Maharjan Rajesh , Regmi Subi , Regmi Gunjan , Kunwar Rajendra , Shrestha Anup 
Published: July 2021

Introduction: Spinal anesthesia has offered a new armamentarium for the anesthesiologists and has been widely used in the Cesarean section in the field of obstetrics, an alternative to general anesthesia. However, Post Dural Puncture Headache remains an inevitable complication of spinal anesthesia and can be minimized its incidence by reducing the size of the needle and changing the design of the needle tip. The objective of the study was to find the incidence of post-dural puncture headache undergoing subarachnoid block for CS using 25G Quincke and 25G Whitacre needles.
Materials and methods: This study was conducted from August 2020 to January 2021 enrolling 72 parturients and were allocated in two groups of 36 each. Group A and B parturients received spinal anesthesia via. 25G Quincke and 25G Whitacre in sitting position respectively. All the patients were evaluated based on incidence, onset, duration, and severity of headache postoperatively for 72 hours after the subarachnoid block.
Results: The incidence of post-dural puncture headache in the study was 7.2% in Group A and 3.15% in Group B which was statistically significant (P-value = 0.011), while there were no significant differences between these two groups in the onset, severity, and duration of post-dural puncture headache.
Conclusion: Despite no significant differences were found for the onset, severity, and duration of post-dural puncture headache, the use of 25G Whitacre is associated with a reduced incidence of post-dural puncture headache compare to 25G Quincke.
Intrathecal catheter for severe low back pain during deep brain stimulation placement: illustrative case
Authors: Kunkler Bryan , Tung Alan , Patil Parag G. , Chiravuri Srinivas , Tarnal Vijay 
Published: July 2021

BACKGROUND
Deep brain stimulation (DBS) is a U.S. Food and Drug Administration–approved therapy for medically refractory Parkinson’s disease, essential tremor, and other neurological conditions. The procedure requires prolonged immobility and can result in significant patient discomfort, potentially limiting patient selection. In addition, surgical requirements necessitate avoidance of medications that may alter or suppress the patient’s arousal or baseline tremor during macrostimulation testing.

OBSERVATIONS
In this study, the authors describe the use of continuous spinal anesthesia with local anesthetic to manage a patient with severe back pain who was intolerant of semisupine position during stereotactic computed tomography and stage 1 of DBS placement.

LESSONS
Continuous spinal anesthesia is an effective strategy to manage patients with severe back pain undergoing DBS surgery for upper extremity motor symptoms.
Studing the css animation with websimulator in extracurricuLar activities
Authors: Karmanova E. V. , Bezborodova O. V. 
Published: July 2021

The article is devoted to the issues of teaching high school students CSS animation (Cascading Style Sheets) in the framework of extracurricular activities using the gamification method. The current problems of teaching web programming at school are considered, its main components are highlighted: HTML page layout, programming on the client and server sides. The analysis of existing services and online games for teaching web layout is presented. As a result of the analysis of the traffic of the studied services, an increased interest of Internet users in web simulators, implemented using the principles of gamification, was revealed. However, today there are a limited number of such services, in addition, many topics of web programming and layout are still unrealized with the help of such web simulators.The article describes a completed project of developing a web simulator for teaching the basic properties of CSS animation. When designing a web simulator, the requirements for the implementation of game mechanics and dynamics were considered, which will make it possible to organize the educational process in a dynamic, exciting and visual way. The article describes the key features of the web simulator, its functional requirements, provides a rationale for the choice of topics and design of the web simulator, and considers the algorithm of its operation. The topics that are studied as a result of passing tasks in the web simulator are listed. The risks associated with the implementation of the web simulator in the educational process are described.The authors carried out an experiment on the basis of an additional education institution "KiberOne Programming School" among 10th grade students, the results of the experiment showed the effectiveness of using the developed web simulator in teaching CSS animation.
Un encuentro con las formas vivientes del discurso de Davi Kopenawa
Authors: Parga-León Ángela 
Published: July 2021

Esta exposición intenta comprender las formas culturales de comunicación y fijación mnémica en una narración específica que Davi Kopenawa, chamán Yanomami, expone al antropólogo Bruce Albert, en virtud de los modos de existencia amazónicos, refiriéndose en particular a la intensidad de los espíritus selváticos y a la experiencia chamánica con los mundos espirituales. En el contexto de una extensión vegetal dispersa y sobresaliente, afirmamos una sociabilidad cotidiana en el marco de una “ética respetuosa o amorosa” entre todas las formas de vida, expresada estéticamente en formas significantes y transportadoras de emociones desarrolladas por la cosmología amazónica. Para ello utilizamos las nociones que Aby Warburg emplea en su estudio de la cultura de las imágenes, en tanto curso por el cual estas pueden entenderse como organismos vivientes susceptibles a transformación, preservando su propia biología en la trasmisión codificada de la memoria.
LncRNA KCNQ1OT1 Secreted by Tumor Cell-Derived Exosomes Mediates Immune Escape in Colorectal Cancer by Regulating PD-L1 Ubiquitination via MiR-30a-5p/USP22
Authors: Xian Di , Niu Liangbo , Zeng Jie , Wang Lei 
Published: July 2021

Background: This study tried to explore the mechanism of long non-coding RNA (lncRNA) KCNQ1OT1 in tumor immune escape.Methods: Gene Expression Omnibus (GEO) and microarray analysis were used to screen the differentially expressed lncRNA and microRNA (miRNA) in normal tissues and tumor tissues. Quantitative reverse transcription PCR (RT-qPCR) was used to quantify KCNQ1OT1, miR-30a-5p, ubiquitin-specific peptidase 22 (USP22), and programmed death-ligand 1 (PD-L1). The interactive relationship between KCNQ1OT1 and miR-30a-5p was verified using dual-luciferase reporter gene assay and ribonucleoprotein immunoprecipitation (RIP) assay. Cell Counting Kit (CCK)-8, clone formation, wound healing, and apoptosis are used to detect the occurrence of tumor cells after different treatments. Protein half-life and ubiquitination detection are used to study the influence of USP22 on PD-L1 ubiquitination. BALB/c mice and BALB/c nude mice are used to detect the effects of different treatments on tumor growth and immune escape in vivo.Results: The expression of lncRNA KCNQ1OT1 in tumor tissues and tumor cell-derived exosomes was significantly increased. The tumor-promoting effect of lncRNA KCNQ1OT1 was through the autocrine effect of tumor cell-derived exosomes, which mediates the miR-30a-5p/USP22 pathway to regulate the ubiquitination of PD-L1 and inhibits CD8+ T-cell response, thereby promoting colorectal cancer development.Conclusion: Tumor cell-derived exosomes’ KCNQ1OT1 could regulate PD-L1 ubiquitination through miR-30a-5p/USP22 to promote colorectal cancer immune escape.
Monocyte Dysfunction Detected by the Designed Ankyrin Repeat Protein F7 Predicts Mortality in Patients Receiving Veno-Arterial Extracorporeal Membrane Oxygenation
Authors: Siegel Patrick M. , Orlean Lukas , Bojti István , Kaier Klaus , Witsch Thilo , Esser Jennifer S. , Trummer Georg , Moser Martin , Peter Karlheinz , Bode Christoph , Diehl Philipp 
Published: July 2021

Background: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is used for critically ill patients requiring hemodynamic support but has been shown to induce an inflammatory response syndrome potentially leading to severe complications and poor outcome. Monocytes are comprised of different subsets and play a central role in the innate immune system. The unique small binding proteins, Designed Ankyrin Repeat Protein “F7” and single chain variable fragment “MAN-1,” specifically detect the activated conformation of the leukocyte integrin Mac-1 enabling the highly sensitive detection of monocyte activation status. The aim of this study was to characterize monocyte function and heterogeneity and their association with outcome in VA-ECMO patients.Methods: VA-ECMO patients were recruited from the ICUs of the University Hospital in Freiburg, Germany. Blood was sampled on day 0 and day 3 after VA-ECMO placement, after VA-ECMO explantation and from healthy controls. Monocyte subset distribution, baseline activation and stimulability were analyzed by flow cytometry using the unique small binding proteins F7 and MAN-1 and the conventional activation markers CD163, CD86, CD69, and CX3CR1. Furthermore, expression of monocyte activation markers in survivors and non-survivors on day 0 was compared. Simple logistic regression was conducted to determine the association of monocyte activation markers with mortality.Results: Twenty two patients on VA-ECMO and 15 healthy controls were recruited. Eleven patients survived until discharge from the ICU. Compared to controls, baseline monocyte activation was significantly increased, whereas stimulability was decreased. The percentage of classical monocytes increased after explantation, while the percentage of intermediate monocytes decreased. Total, classical, and intermediate monocyte counts were significantly elevated compared to controls. On day 0, baseline binding of F7 was significantly lower in non-survivors than survivors. The area under the ROC curve associated with mortality on day 0 was 0.802 (p = 0.02).Conclusions: Distribution of monocyte subsets changes during VA-ECMO and absolute classical and intermediate monocyte counts are significantly elevated compared to controls. Monocytes from VA-ECMO patients showed signs of dysfunction. Monocyte dysfunction, as determined by the unique tool F7, could be valuable for predicting mortality in patients receiving VA-ECMO and may be used as a novel biomarker guiding early clinical decision making in the future.
Taurisolo®, a Grape Pomace Polyphenol Nutraceutical Reducing the Levels of Serum Biomarkers Associated With Atherosclerosis
Authors: Annunziata Giuseppe , Ciampaglia Roberto , Maisto Maria , D'Avino Maria , Caruso Domenico , Tenore Gian Carlo , Novellino Ettore 
Published: July 2021

Trimethylamine-N-oxide (TMAO) is a gut microbiota-derived metabolite recognized as strongly related to cardiovascular diseases (CVD), mainly increasing the risk of atherosclerosis development. Currently, no pharmacological approaches have been licensed for reduction of TMAO serum levels and conventional anti-atherosclerosis treatments only target the traditional risk factors, and the cardiovascular risk (CVR) still persist. This underlines the need to find novel targeted strategies for management of atherosclerosis. In this study we tested the ability of a novel nutraceutical formulation based on grape pomace polyphenols (Taurisolo®) in reducing both the serum levels of TMAO and oxidative stress-related biomarkers in humans (n = 213). After chronic treatment with Taurisolo® we observed significantly reduced levels of TMAO (−49.78 and −75.80%, after 4-week and 8-week treatment, respectively), oxidized LDL (oxLDL; −43.12 and −65.05%, after 4-week and 8-week treatment, respectively), and reactive oxygen species (D-ROMs; −34.37 and −49.68%, after 4-week and 8-week treatment, respectively). On the other hand, no significant changes were observed in control group. Such promising, the results observed allow indicating Taurisolo® as an effective nutraceutical strategy for prevention of atherosclerosis.Clinical Trial Registration: This study is listed on the ISRCTN registry with ID ISRCTN10794277 (doi: 10.1186/ISRCTN10794277).
Pore Structure Characteristics and Its Effect on Mechanical Performance of Cemented Paste Backfill
Authors: Huan Chao , Zhu Chao , Liu Lang , Wang Mei , Zhao Yujiao , Zhang Bo , Zhang Xiaoyan 
Published: July 2021

The development of cemented paste backfilling (CPB) technology has made an important contribution to the mining economy. As a kind of porous material, the pore structure characteristic of cemented paste backfill (CPB) is strongly correlated to its mechanical properties. In this study, CPB specimens were prepared with tailings/cement ratios (T/C ratio) of 4, 6, 10 and curing durations of 3, 7, 14, and 28 days, respectively. Pore structures characteristics of CPB specimens were investigated using nuclear magnetic resonance (NMR) and scanning electronic microscopy (SEM). The uniaxial compressive strength (UCS) was adopted to illustrate the mechanical property of CPB specimens. The coupling effects of T/C ratio and curing time on the pore characteristics of CPB as well as the effect of pore size on the UCS were analyzed. The results indicated that: 1) the microstructural integrity of CPB was highly related to the development status of the pore structure, which can be represented by micro-parameters like porosity, average pore area, etc. 2) a similar normal distribution curve was observed from the four kinds of pore structure in CPB. As the curing time increased, the peak of the pore size curve shifted left, and the peak value decreased, which means that the pore size in CPB decreased and became much concentrated; 3) the extension of the most probable pore size led to the cross-connection of pores and resulted in the fracture of CPB, which was shown as a crack on the main section.