bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personal and Emotional Factors in the Labour Integration of University Graduates in the Field of Education. Implications for University Teaching
Authors: Castejón Juan L. , Gilar Raquel , Miñano Pablo 
Published: November 2021

The main aim of this paper is to analyse the role of intellectual, personal and emotional competencies as well as technical knowledge - academic achievement - in the employment ofuniversity graduates, with the purpose of incorporating these competencies into training programmes developed within the European Framework of Higher Education. This study is based on an initial sample of 118 university graduates in the field of education. We have gathered information about academic achievement and the intellectual, personal and emotional traits of this sample. From these data, and given the importance ofnon-intellectual aspects of intelligence associated with professional success, the specific contribution -incremental validity - of personal and emotional intelligence in explaining theemployment - labour integration - of university graduates in the field of education is studied. From this point onwards, we attempt to identify the key socio-emotional competencies inthe field of education in order to establish the implications of including this type of skills in university training programmes within the European Higher Education Area.
Designing Dynamic Systems For Advancing Aesthetic Spatial Engagement In Sound Art
Authors:   , Johnson Bridget 
Published: November 2021

<p>This thesis documents three years of extensive research into the field of sonic spatial expression and is the culmination of years of fascination about all of the ways music is made. In particular, it focuses on the way sounds move through space. This research stems from artistic practice and a desire to deeply explore spatial aesthetics in sound art. A potential for further development of tools designed for aesthetic engagement with spatial attributes of music is identified. It is proposed that with new tools designed for the manipulation of spatial attributes, new spatial aesthetics might emerge. In exploring this proposition, a number of contributions to the field of spatial sound art are presented. The main approach taken is to apply new technologies to the design of spatialisation performance interfaces. It is hoped that in designing novel interfaces that specifically engage with spatial parameters, new ways for aesthetically engaging with space will be afforded for composers and performers. The tools designed all aim to exhibit a high level of intuitiveness in their control systems, allowing non- expert users access to these spatially expressive tools. Additionally, the new tools aim to provide high levels of expressivity so that advanced composers who are looking for new ways to use space expressively may also use them. This thesis focuses on the design, development, implementation, analysis, and artistic use of new spatial interfaces. The design methodology implemented for all of the interfaces includes both testing and analysis phases that involve the composition and performance of new musical works. The development of the interfaces is closely coupled with the development of the new musical works, with each design phase applied to a new work and each new work or spatial idea exploring the new aesthetics afforded by the tools. The assessment of these new tools takes various forms: they are assessed by critical evaluation of the new works created, by user study evaluations from other composers who utilise the tools, and, where appropriate, by quantifiable methods of evaluation that are adopted to assess specific spatialisation tools. The new musical interfaces presented, described, and evaluated in this document were conceived of as musical instruments, each affording new approaches to spatial expression. This document also details an extensive collection of new musical works that feature the interfaces. It concludes by suggesting future directions for this research body and the spatialisation interface design field.</p>
Là où dialoguent les musées: The Museum of New Zealand Te Papa Tongarewa at the Musée du Quai Branly
Authors:   , Phillips Lily 
Published: November 2021

<p>The opening of the Musée du quai Branly in 2006 signalled a new approach to the display of Māori and Pacific collections in France and the beginning of a new relationship with the Museum of New Zealand Te Papa Tongarewa. Between 2006 and 2012, the two museums were brought together by two challenging events: the repatriation of toi moko (Māori tattooed heads) from France to New Zealand and the 2011 exhibition Maori: leurs trésors ont une âme at the quai Branly. Through a close study of the repatriation and exhibition, and interviews with participants, this thesis considers the questions these events raise. How can museums with very different approaches to the treatment of artefacts negotiate issues of repatriation and the exhibition of sacred objects? How should colonial-era anthropological collections be exhibited today? What is the place of contemporary indigenous art in the museum? By focusing on the exchanges between two institutions, Te Papa and the quai Branly, this thesis suggests how conversations at an individual level can lead to shifts in the perception and exhibition of museum objects, and how dialogues between museums internationally can contribute to an evolution in the treatment and display of indigenous artefacts and art in museums.</p>
Proteomics of lipid accumulation and DGAT inhibition in HepG2 liver carcinoma cells
Authors:   , Bhatt-Wessel Bhumika 
Published: November 2021

<p>Non-alcoholic fatty liver disease (NAFLD) is a manifestation of the metabolic syndrome in the liver. It is marked by hepatocyte accumulation of triacylglycerol (TAG) rich lipid droplets. In some patients, the disease progresses to non-alcoholic steatohepatitis (NASH), characterized by cellular damage, inflammation and fibrosis. In some cases, cirrhosis and liver failure may occur. However, the pathogenesis of NAFLD is still unclear. The present project is based on the hypothesis that hepatocytes are equipped with mechanisms that allow them to manage lipid accumulation to a certain extent. Continued or increased lipid accumulation beyond this triggers molecular mechanisms such as oxidative stress, lipid peroxidation and cell death that aggravate the condition and cause disease progression. The aim of this project is to study the effects of lipid accumulation on the cells using proteomics approach to identify proteins involved in the disease progression. A cell culture model was used in the study. HepG2 cells, a human liver carcinoma cell line, were treated with a mixture of fatty acids (FA) to induce lipid accumulation. The lipid accumulation in HepG2 cells was measured with Oil red O assay and the effect of lipid accumulation on the proliferation of the cells was measured using an MTT cell proliferation assay. HepG2 cells treated with 1 mM FA mixture for 6 hours induced lipid accumulation 1.4 times of control with 90% of cell proliferation capacity of the control cells. The final and the only committed step in TAG biosynthesis is catalysed by acyl-CoA diacylglycerol acyltransferase (DGAT) enzymes. To investigate if limiting lipid accumulation in HepG2 cells would prevent molecular mechanisms of pathogenesis, inhibition of DGAT by small molecule inhibitors was performed. Among the three DGAT inhibitors (A922500, PF06424439 and PF04620110) tested, PF04620110 reduced the lipid accumulation to 1.2 fold of the control cells when they were treated with 100 μM of the inhibitor in the presence of 1 mM FA mixture for 6 h. Proteomic analyses were carried out for the control, FA-treated and inhibitor-treated cell groups to identify protein changes in the abundance. Functional analyses of the changed proteins identified suggest that lipid accumulation tends to adversely affect the functioning of the ER and the mitochondria. A complex interplay between the two organelles, possibly mediated by Ca2+ signalling may be vital in ensuring cell survival. PF04620110 was able to counter the FA induced changes in the abundance of some proteins involved in the metabolic processes but it had limited effect on the ER chaperones whose abundance in the inhibitor-treated sample was comparable to that of the FA-treated sample. These data provided important information for future discoveries of biomarkers and molecular mechanisms involved in the progression of NAFLD.</p>
Asymptotic methods of testing statistical hypotheses
Authors:   , Nguyen Thuong 
Published: November 2021

<p>For a long time, the goodness of fit (GOF) tests have been one of the main objects of the theory of testing of statistical hypotheses. These tests possess two essential properties. Firstly, the asymptotic distribution of GOF test statistics under the null hypothesis is free from the underlying distribution within the hypothetical family. Secondly, they are of omnibus nature, which means that they are sensitive to every alternative to the null hypothesis. GOF tests are typically based on non-linear functionals from the empirical process. The first idea to change the focus from particular functionals to the transformation of the empirical process itself into another process, which will be asymptotically distribution free, was first formulated and accomplished by {\bf Khmaladze} \cite{Estate1}. Recently, the same author in consecutive papers \cite{Estate} and \cite{Estate2} introduced another method, called here the {\bf Khmaladze-2} transformation, which is distinct from the first Khmaladze transformation and can be used for an even wider class of hypothesis testing problems and is simpler in implementation.	This thesis shows how the approach could be used to create the asymptotically distribution free empirical process in two well-known testing problems.	The first problem is the problem of testing independence of two discrete random variables/vectors in a contingency table context. Although this problem has a long history, the use of GOF tests for it has been restricted to only one possible choice -- the chi-square test and its several modifications. We start our approach by viewing the problem as one of parametric hypothesis testing and suggest looking at the marginal distributions as parameters. The crucial difficulty is that when the dimension of the table is large, the dimension of the vector of parameters is large as well. Nevertheless, we demonstrate the efficiency of our approach and confirm by simulations the distribution free property of the new empirical process and the GOF tests based on it. The number of parameters is as big as $30$. As an additional benefit, we point out some cases when the GOF tests based on the new process are more powerful than the traditional chi-square one.	The second problem is testing whether a distribution has a regularly varying tail. This problem is inspired mainly by the fact that regularly varying tail distributions play an essential role in characterization of the domain of attraction of extreme value distributions. While there are numerous studies on estimating the exponent of regular variation of the tail, using GOF tests for testing relevant distributions has appeared in few papers. We contribute to this latter aspect a construction of a class of GOF tests for testing regularly varying tail distributions.</p>
Design Optimisation for 3D printed SLM objects
Authors:   , Hill Stephen Tane 
Published: November 2021

<p>A common misconception about additive manufacturing (3D printing) is that any shape can be made in any material at the press of a button. The reality is that each process and material requires distinct Computer Aided Design (CAD) files that need to be optimised to the physical limitations of the manufacturing process. This optimisation process can have significant effects on the designer’s aesthetic intentions. Selective Laser Melting (SLM) is the new benchmark for functional 3D printed titanium designs where the optimisation process plays an important role in the outcome of the end product. The limitations imposed by the manufacturing process include build support material, heat transfer and post processing and designs are required to be optimised before the manufacturing process can commence. To date, case studies written on the SLM process have focused largely on engineering and functional applications in particular within the medical industry. However; this process has not been extensively studied from a visual and aesthetic industrial design perspective. This research will gather specific knowledge about the technical limitations involved in the Selective Laser Melting process and explore through a case study approach how a designer s intentions can be maintained or even enhanced when using this technology. With greater understanding of the SLM technology, the optimisation process may further provide positive outcomes to the designer by saving time, money and waste. This case study is built on an existing product design file as a base model. Refinements to the model were made based on findings from existing design research as well as digital and physical models. The existing design research was focused on challenges designers encounter using 3D printing technologies including SLM as well as the optimisation process. Models and design iterations were developed using Nigel Cross’s four step model of exploration, generation, evaluation and communication. By iteratively redesigning aspects of the model to conform to the SLM limitations, this study reviews opportunities for areas to reduce material without compromising the design intent.</p>
Improving knowledge transfer: A realist evaluation of the implementation of knowledge transfer pathways by a health research funder
Authors:   , Middleton Lesley 
Published: November 2021

<p>Organisations whose mission is to fund health research are increasingly concerned with ensuring that the research they fund is used productively. The resulting interest in the concept of “knowledge transfer” has involved introducing policies to prompt researchers to think about their role, not just as knowledge producers, but as translators of research findings. In New Zealand, researchers can be asked, in their application for funds, to provide an account of what will happen to their research results. They are then judged on the quality of that account. However, little is known about how effectively this type of policy influences researchers to do more to make connections with those who use their findings. Using the explanatory power of the realist evaluative approach, this thesis examines the implementation of new instructions by the Health Research Council of New Zealand (HRC) for providing knowledge transfer pathways in research applications. A focus of the research is on how these instructions change (or do not change) the mind-set of researchers. Key informant interviews were held, and the scholarly and grey literature examined, to develop an initial theory on how researchers would be influenced by such instructions. Individual interviews were then held with researchers, seeking their reflections on what they had originally written in a specific knowledge transfer pathway and how this then matched up with what actually happened; these interviews were then used to refine the initial theory. Finally, an on-line survey was conducted with those who sat on the HRC’s research assessing committees in the 2014/15 funding round in order to refine the theory further. The final theory identified six mechanisms, which under different contexts, explain how the HRC’s knowledge transfer policy works (or does not work) to prompt researchers to reason differently. A continuum of reasoning in the form of a dimmer switch was used to explain circumstances where researchers may become more mindful of what is involved in knowledge transfer, but were not likely to markedly change their behaviours. Based on the assumption that the HRC wants to be more active in encouraging researchers to undertake activities other than producing research results, two recommendations are made: (1) knowledge transfer policies should support self-reflexivity by different groups of researchers rather than creating more hoops within the research application process, and (2) the processes by which knowledge transfer sections are judged needs to be strengthened if researchers are going to be confident that this is a “serious” part of the application process.</p>
The Art of Chronic Pain: Creating an Exhibition Proposal on Chronic Pain for a New Zealand Gallery
Authors:   , Wells Melissa 
Published: November 2021

<p>The original idea for this research came from a combination of the work that Richard Sandell has done on social inclusion in the United Kingdom, and my personal experiences with chronic pain. The aim of this research is to make known the experiences of chronic pain survivors in New Zealand and also to bring understanding about a range of invisible illnesses where chronic pain is a major symptom. Research methods used include surveys using quota sampling and content analysis, case studies, and an exhibition proposal. People living with chronic pain make up one in five New Zealanders, meaning just over 900,000 people have this condition/disability/illness. Yet, have you heard anyone talk about it? Cancer is often spoken about, but it only effects around 20,000 New Zealanders. Mental health problems are contemporaneous but only effect approximately 582,000 people in New Zealand. However chronic pain cannot kill, or can it? Many people who have chronic pain have other co-morbid disorders such as depression. Chronic pain needs more publicity, it yearns to be spoken about and understood. People with chronic pain have said that they feel misunderstood and unheard not only by family, friends and colleagues but also by their medical professionals as well. This research looks at whether there would be support from both the chronic pain community and healthy New Zealanders for an art exhibition about chronic pain. The exhibition would contain art produced by people with chronic pain and depict their daily lives with their condition(s). It also offers a contribution to museum studies and current practice by attending to a gap in the New Zealand literature, not even well covered by overseas literature, on this subject. It is the first dissertation to focus on pain in a museum/gallery setting in New Zealand and opens up public interaction and discussion about a taboo topic. New Zealand museums and galleries have to have the ability to challenge preconceived opinions and ideas about chronic pain, as well as the opportunity to engage with a large and often invisible community.</p>
The effect of clozapine and MIS416 on demyelination, remyelination and immunomodulation in the murine cuprizone model
Authors:   , Templeton Nicola 
Published: November 2021

<p>Multiple Sclerosis (MS) is a disorder of the central nervous system that affects approximately 2.5 million people worldwide. Due to the heterogeneous nature of the disease, and the want of an identified cause, treatment of MS remains difficult. Treatments are available, however these are limited in efficacy and are not suitable for all forms of MS. Disease pathology is characterised by the formation of demyelinating lesions in the central nervous system (CNS) which lead to cognitive and motor impairments associated with the disease. These CNS lesions can be classified as those with immune cell involvement or those without immune cell infiltrate, which are more commonly seen in progressive forms of MS, and currently, there are no treatments available for progressive MS. Due to the limited options available for treating progressive MS, this thesis aims to identify the therapeutic effect provided by the immunomodulatory compounds, MIS416 and clozapine, in a non-immune mediated model of MS, which is believed to more closely resemble progressive disease. Both of these compounds have been shown previously to reduce disease burden in an immune-driven animal model of MS. To investigate the effect of immune-modulating therapies on lesions without immune cell infiltrate, the cuprizone model of non-immune demyelination was used. In summary, the work presented in this thesis found that treatment with MIS416 and clozapine led to improved performance on behavioural assays, although neither agent inhibited cuprizone-induced demyelination or enhanced remyelination. The cellular mechanism behind the observed behavioural improvement is yet to be confirmed. MIS416 was able to maintain its previously identified immunomodulatory properties when administered in this novel setting. Moreover, novel changes to serum growth factors were identified that could provide unexpected benefit to MS patients administered MIS416. In addition to reversing cuprizone-induced behavioural deficits, clozapine reduced LPS-driven inflammatory cytokine production by microglia, indicating that clozapine has the ability to directly reduce inflammation, which may benefit progressive MS patients. Protective effects provided by either of these compounds could aid in the development of unique combination therapies to target both the inflammatory immune component and the cellular components seen at different stages of MS. MIS416 induced changes to serum cytokines and growth factors in the periphery could be harnessed to treat not just MS but other auto-immune diseases characterised by a similar cytokine profile.</p>
A gravity analysis of the Alpine Fault and the DFDP-2 drill site, Whataroa valley, South Westland, South Island, New Zealand
Authors:   , Jenkins Stephen 
Published: November 2021

<p>The second phase of drilling into the Alpine Fault (DFDP-2), was completed in the Whataroa River valley, a former glacial valley located in central Westland, South Island, New Zealand. The site is located next to a steep hillside on the hanging-wall, ~1 km southeast of the mapped surface trace of the Alpine Fault. Projection of the hillside suggests a sediment thickness of 100 ± 40 m at the drill site; however, the sediment thickness was approximately double pre-drill estimates. Additionally, the surface expression and shallow geometry of the Alpine Fault in the Whataroa River valley, is not well-defined due to post-glacial burial of the fault zone. This thesis describes a gravity study designed to better constrain sub-surface structure beneath the DFDP-2 drill site and across the Alpine Fault. During this study, 466 new high-precision gravity observations were collected (standard error = 0.015 mGal) and amalgamated with 134 existing gravity stations, yielding comprehensive coverage of gravity data across the study area. A high density of observations was achieved within pre-determined zones, in addition to regional measurements so that residual gravity anomaly maps could be produced. The maps reveal: a negative residual gravity anomaly interpreted as a dextrally-offset glacial channel at least 350-450 m deep; steep localised gravity gradients near the Alpine Fault and DFDP-2 drill site that are interpreted as faulted and/or eroded boundaries; and a negative gravity anomaly adjacent to the DFDP-2 drill site that is interpreted as the deepest point of an over-deepened glacial lake. Gravity models were used to estimate the bedrock-sediment interface geometry near the DFDP-2 drill site and Alpine Fault. Structural inversion of the density boundary next to the drill site suggests either a moderately-dipping reverse fault or sub-vertical erosional wall exists beneath the hillside. Additional constraints on physical properties from direct density measurements or seismic velocity determinations and direct constraints on sediment thickness and layer geometry from seismic surveys will in future allow this new high-precision gravity dataset to be modelled more effectively.</p>