bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Combined Effects of ENSO and Arctic Oscillation on Wintertime Fog Days in Eastern China
Authors: Yu Huaying , Liu Peng , Zhang Ying 
Published: February 2021

Abstract
The data of fog days from weather observation stations in China and the NCEP/NCAR re-analysis data from 1954 to 2007 are used to investigate the combined effects of El Niño and Southern Oscillation (ENSO) and Arctic Oscillation (AO) on the number of winter fog days in eastern China. The results show that during El Niño the enhanced low-level southwesterly warm-moist airflow could lead to the temperature rise and humidity increase in eastern China. Note that the rate of humidity increase is faster than the rate of temperature rise, which makes the air in eastern China easy to be saturated. Besides, in winter the North China is dominated by the sinking airflow, so a large-value area of fog days appears in eastern China with the center in North China. While in La Niña years, the atmospheric circulation and its influence on the fog days are the opposite. During the positive AO period, the East Asian trough weakens and the low-level westerly jet moves northward, preventing northwesterly cold air from moving southward. The warming and humidification of North China and the slight temperature drop in South China would cause more fog days in North China and fewer fog days in South China. The effect of negative AO is opposite to that of positive AO. The combined effects of ENSO and AO are far greater than the sum of their individual effects. Under El Niño and positive AO, the number of fog days would increase significantly in North China during the whole winter. Besides, ENSO has greater impacts than AO during early winter and vice versa during later winter.
Amino Terminal Recognition by a CCR6 Chemokine Receptor Antibody Blocks CCL20 Signaling and IL-17 Expression via β-arrestin
Authors: Gómez-Melero Sara , García-Maceira Fé Isabel , García-Maceira Tania , Luna-Guerrero Verónica , Montero-Peñalvo Gracia , Túnez-Fiñana Isaac , Paz-Rojas Elier 
Published: February 2021

Abstract
Background: CCR6 chemokine receptor is an important target in inflammatory diseases. Th17 cells express CCR6 and a number of inflammatory cytokines, including IL-17 and IL-22, which are involved in the propagation of inflammatory immune responses. CCR6 antagonist would be a potential treatment for inflammatory diseases such as psoriasis or rheumatoid arthritis. The aim of this study is to develop an antagonistic monoclonal antibody (mAb) against human CCR6 receptor (hCCR6).Results: We generate monoclonal antibodies against hCCR6 immunizing Balb/c mice with hCCR6 overexpressing cells. The antibodies were tested by flow cytometry for specific binding to hCCR6, cloned by limiting dilution and resulted in the isolation and purification monoclonal antibody 1C6. By ELISA and flow cytometry, was determined that the antibody obtained binds to hCCR6 N-terminal domain. The ability of 1C6 to neutralize hCCR6 signaling was tested and we determined that 1C6 antibody were able to block response in β-arrestin recruitment assay with IC50 10.23 nM, but did not inhibit calcium mobilization. In addition, we found in a chemotaxis assay that 1C6 reduces the migration of hCCR6 cells to their ligand CCL20. Finally, we determined by RT-qPCR that the expression of IL-17A in Th17 cells treated with 1C6 was inhibited.Conclusions: In the present study, we applied whole cell immunization for successfully obtain an antibody that is capable to neutralize hCCR6 signaling and to reduce hCCR6 cells migration and IL-17 expression. These results provide an efficient approach to obtain therapeutic potential antibodies in the treatment of CCR6-mediated inflammatory diseases.
Hiccups Induced by Aripiprazole Combined With Sertraline in an Adolescent With Olfactory Reference Disorder: a Case Report
Authors: Li Zhe , Li Yang , Xiong Zhenzhen , Li Zhixiong , Yuan Yiwen , Deng Junfeng , Li Xiao 
Published: February 2021

Abstract
BackgroundHiccup can cause significant distress to patients and affect medication compliance. Individuals with olfactory reference disorder (ORD) who might develop persistent hiccups when treated with a combination of antidepressant and antipsychotic, leading to significant distress and impairment. Case presentationWe report a rare case of an adolescent with ORD who was treated with aripiprazole combined with sertraline and who began to hiccup persistently after 6 days on this treatment. He stopped hiccupping after the aripiprazole had been suspended for 12 h. After discharge, the patient continued on sertraline alone and reported no hiccupping at one-month follow-up. ConclusionsClinicians should consider that the combination of aripiprazole and sertraline can induce hiccups during the acute administration period in adolescents with ORD.
ADAM10 and ADAM17 in Liver Regeneration and Fibrosis: Regulation of EGFR, c-Met and TNF RI Signalling
Authors: Zbodakova Olga , Chalupsky Karel , Sarnova Lenka , Kasparek Petr , Jirouskova Marketa , Gregor Martin , Sedlacek Radislav 
Published: February 2021

Abstract
ADAM10 and ADAM17 are proteases that affect multiple signalling pathways by releasing molecules from the cell surface. As their substrate specificities partially overlaps, we investigated their concurrent role in liver regeneration and fibrosis, using three liver-specific deficient mouse lines: ADAM10- and ADAM17-deficient lines, and a line deficient for both proteases. In the model of partial hepatectomy, double deficient mice exhibited decreased AKT phosphorylation, decreased release of EGFR activating factors and lower shedding of HGF receptor c-Met. Thus, simultaneous ablation of ADAM10 and ADAM17 resulted in impaired EGFR signalling, while HGF/c-Met signalling pathway was enhanced. In contrast, antagonistic effects of ADAM10 and ADAM17 were observed in the model of chronic CCl4 intoxication. While ADAM10-deficient mice develop more severe fibrosis manifested by high ALT, AST, ALP and higher collagen deposition, combined deficiency of ADAM10 and ADAM17 surprisingly results in comparable degree of liver damage as in control littermates. Therefore, ADAM17 deficiency is not protective in fibrosis development per se, but can ameliorate the damaging effect of ADAM10 deficiency on liver fibrosis development and results in decreased shedding of TNF RI, while ADAM10 deficiency leads to increased levels of soluble TNF RI in serum. In conclusion, hepatocyte-derived ADAM10 and ADAM17 are important regulators of growth receptor signalling and TNF RI release, and pathological roles of these proteases are dependent on the cellular context.
Relativistic Modifications in Galactic Rotation Curves under a Toroidal Galactic Field
Authors: Mirza Babur M. 
Published: February 2021

Abstract
Rotational dynamics of galaxies exhibits an increase beyond the Keplerian velocity which corresponds to a missing mass up to six times the dynamic mass in the observable universe. In this paper we show that the observed increase in galactic rotation velocities is a general relativistic effect resulting from the combined effect of toroidal magnetic energy density in galaxies and spacetime dragging due to the rotating compact mass in galactic center. The effect of magnetic energy density on spacetime vorticity is derived from Maxwell equations in axially symmetric spacetime where the dragging effects are shown to extend farther in the galactic disc via the toroidal field, modifying the rotational speed of the galactic matter. This is shown to lead to the diverse rotation curves of spiral galaxies, along with the Tully-Fisher relation for total galactic mass and maximum rotational velocity.
A Visible Light Communication Channel Model for Agronomic Environments
Authors: Quispe Hugo Sanchez , Játiva Pablo Palacios , Zaquinaula Freddy Ajila , Naranjo Santiago Logroño , Saavedra Hilter Figueroa , Cañizares Milton Román 
Published: February 2021

Abstract
Currently, agriculture based on agronomic greenhouses is replacing traditional agriculture. This technique reduces dependence on rain on crops. It also generates a controlled internal environment making optimal use of land and water resources. However, this environment needs more care and attention compared to traditional agriculture. To overcome this limitation, various radio frequency (RF)-based technologies can be used. Nevertheless, studies show that the use of communications in RF bands degrades crops' growth and quality. Therefore, an efficient solution is to use the visible light spectrum for communication, the main technology of which is called visible light communication (VLC). Despite numerous studies for the application of VLC in indoor environments, specific VLC systems for agronomic greenhouse environments or their channel models are not yet investigated in depth. To collaborate on state of art on this topic, we present in this paper a novel channel model that incorporates specific factors that affect the quality of VLC systems in agronomic greenhouse environments. Factors such as the random position and orientation of the transmitters and external environmental agents such as atmospheric and different noise types are considered. These components are integrated into an analytical framework by developing the mathematical model of the VLC channel. Furthermore, the analytical expressions of the received power, the signal-to-noise-ratio (SNR), and the bit error rate (BER) are obtained. A VLC system applied to an agronomic greenhouse scenario is developed through computer simulations to validate the mathematical analysis. The results show that illuminance is adequate for the efficient operation of the greenhouse. Besides, the influence of atmospheric factors and noises on the magnitude and temporal dispersion of the channel impulse response is verified. Finally, the results show the system's performance in terms of SNR and BER, observing their differences compared to a traditional indoor VLC system.
The equivalent modulus of elasticity of soil mediums for designing shallow foundations
Authors: Pantelidis Lysandros 
Published: February 2021

Abstract
As known, in a Winkler type of analysis the soil medium underneath the foundation is violently replaced by a row of parallel springs having constant ks. For the effective calculation of the latter, which is called the modulus of subgrade reaction, the two elastic constants of the soil (the elastic modulus, E and the Poisson’s ratio, ν) must be known. Although for homogenous soils this generally seems not to be a problem, the same does not stand for stratified mediums or mediums with linearly increasing modulus with depth. In such an analysis, the proper pair of elastic constant values of soil should be selected. This refers to a Poisson’s ratio value equal to zero corresponding to the deformation pattern of springs (compression with no lateral expansion) and the respective modulus. In the present paper a method for calculating the equivalent elastic constants for the above mentioned mediums is proposed based on the theory of elasticity combining the principle of superposition. Various cases are considered, since the equivalent modulus, Eeq, depends on the rigidity and the shape of the footing. As shown, the derived Eeq values not only return reliable settlement results, but also settlement profiles that are similar to those corresponding to the original soil mediums.
SLC7A5 Promotes Colorectal Cancer Progression by Regulating Cell Cycle and Migration
Authors: Tang Baiyou , Zhang Lihua , Yu Jing , Peng Mingjing , Cheng Yu , Hu Dongli , Liu Yongbin , Guo Ying , Zhou Honghao 
Published: February 2021

Abstract
Background: Solute carrier family 7 member 5 (SLC7A5) was identified highly expressed and as a key participant in various tumor development; however, the role it played in colorectal cancer remains unclear. Methods and Results: In the current study, the expression of SLC7A5 were systematically mined in public databases and validated by real-time PCR in colon cancer and normal tissues. And then, the co-expression and pathway analysis got from public database, which indicated the potential influence of SLC7A5 for the etiology of colorectal cancer, were evaluated in the colon cancer cell lines by loss of SLC7A5 function experiment, flow cytometry, western blot, and wound healing assay. The results showed that the mRNA expression of SLC7A5 was significantly higher in colorectal cancer tissues than that in the non-tumor controls for GEO and TCGA datasets as well as 40 pairs of Xiangya clinical samples. The functional enrichment analysis based on public database showed that the pathways enriched most were cell cycle and epithelial-to-mesenchymal transition (EMT), and Cyclin D1 (CCND1) were the only gene that had a significant positive correlation with SLC7A5. Loss of SLC7A5 function in colon cancer cell lines could arrest cell cycle at G1 phase by down-regulating CCND1 and CDK2 protein expression, and may reduce cell migration by reversing EMT though upregulation of E-Cadherin and downregulation of zonula occludens-1. Conclusion: SLC7A5 is likely associated with the progression of colon cancer.
A Generative Adversarial Network Technique for High-Quality Super-Resolution Reconstruction of Cardiac Magnetic Resonance Images
Authors: Zhao Ming , Wei Yang , Wong Kelvin Kian Loong 
Published: February 2021

Abstract
Objective: In this paper, we proposed a Denoising Super-resolution Generative Adversarial Network (DnSRGAN) method for high-quality super-resolution reconstruction of noisy cardiac magnetic resonance (CMR) images.Methods: This method is based on feed-forward denoising convolutional neural network (DnCNN) and SRGAN architecture. Firstly, we used a feed-forward denoising neural network to pre-denoise the CMR image to ensure that the input is a clean image. Secondly, we use the gradient penalty (GP) method to solve the problem of the discriminator gradient disappearing, which improves the convergence speed of the model. Finally, a new loss function is added to the original SRGAN loss function to monitor GAN gradient descent to achieve more stable and efficient model training, thereby providing higher perceptual quality for the super-resolution of CMR images.Results: We divided the tested cardiac images into 3 groups, each group of 25 images, calculated the Peak Signal to Noise Ratio (PSNR) /Structural Similarity (SSIM) between Ground Truth (GT) and the images generated by super-resolution, used them to evaluate our model, and Compared with the current widely used method: Bicubic ESRGAN and SRGAN, our method has better reconstruction quality and higher PSNR/SSIM score.Conclusion: We used DnCNN to denoise the CMR image, and then using the improved SRGAN to perform super-resolution reconstruction of the denoised image, we can solve the problem of high noise and artifacts that cause the cardiac image to be reconstructed incorrectly during super-resolution. Furthermore, our method is capable of high-quality reconstruction of noisy cardiac images.
The Evidence Mapping and Methodological Quality of Clinical Practice Guidelines of Diagnosis and Management for Spinal Pain: A Cross-Sectional Study
Authors: Huang Jin-Feng , Qin Zongshi , Zheng Xuan-Qi , Lin Jia-Liang , Zhang Kai , Li Yan Michael , Wang Yi-Xiang , Wu Ai-Min 
Published: February 2021

Abstract
Objectives: To systematically review clinical practice guidelines (CPGs) for treating spinal pain, to assess the quality of different CPGs, and finally to provide an evidence map for the specific explication of research trends and gaps.Method: We searched CPGs in PubMed, Embase, Web of Science, Guidelines International Network (GIN), National Health and Medical Research Council (NHMRC), Scottish Intercollegiate Guidelines Network (SIGN) and the National Institute for Health and Care Excellence (NICE). We extracted basic information, recommendations, methodological quality, and reporting quality of the CPGs. Four researchers independently evaluated the quality of the CPGs according to the Appraisal of Guidelines Research and Evaluation (AGREE II) and Reporting Items for Practice Guidelines in Healthcare (RIGHT). Results: According to the AGREE II checklist, we found that the mean score was relatively high in four domains, namely, scope and purpose (78.39), stakeholder involvement (63.04), clarity of presentation (72.04), and rigor of development (61.25). However, the mean score of two domains (editorial independence and application) was relatively low. Among the seven domains of the RIGHT checklist, one field (basic information) had the highest reporting rate (86.61%), while another field (funding, declaration, and management of interest) obtained the lowest reporting rate (53.00%). Conclusion: Our study provided evidence mapping, which is a good tool to reduce research waste and facilitate the process of knowledge transfer. The results of our study can also be used to optimize the implementation of these recommendations and to improve the development of reliable CPGs for treating spinal pain.
Outcomes of Recovered COVID-19 Patients: 6 Months of Sequential Observations at a Designated Tertiary Center
Authors: Cao Jie , Wei Wei , Chen Xianmeng , Ryu Jay H. , Hu Xiaowen 
Published: February 2021

Abstract
Objectives: An ongoing global pandemic of coronavirus disease 2019 (COVID-19) has affecting almost 100,000,000 cases with 2,100,000 deaths worldwide. However, the long-term outcomes of recovered patients remain to be defined.Methods: This is a prospective observational study of patients with COVID-19 using sequential assessments after hospital discharge from a designated tertiary center in Hefei, China. We examined clinical symptom, chest CT imaging, pulmonary function, and 6-min walk distance (6-MWD).Results: There were 62, 61 and 51 discharged patients enrolled the 1-month, 3-month and 6-month observations, respectively. Symptoms persisted in 24 (39%), 25 (41%) and 5 (10%) patients, mainly cough in 31%, 15% and 8% of them, respectively. Mild restrictive pulmonary impairment was detected in 11%, 10%, 12% of patients at 1, 3, 6-month follow-up. Although chest CT scores were overall gradually improved at 1 month (5.0±5.1), 3 months (3.0±4.5) and 6 months (2.0±3.3) compared with that during hospitalization (11.0±6.8), residual CT abnormalities were seen in 73%, 54% and 43% of them at 1, 3, 6 months. At 6-month follow-up, the 6MWD was 541±59 m in these recovered patients, which was significantly lower compared to healthy controls (589±75 m，p<0.01). Only the steroid treatment during hospitalization (p=0.009, OR 12.091, 95% CI 1.882 to 77.678) was associated with abnormal CT score at 6 months.Conclusions: At 6 months after hospital discharge, respiratory symptoms and pulmonary function were improved in most COVID-19 patients while residual impairments were still present in both chest CT images and exercise capacity.
A Systematic Review of School Health Policy Measurement Tools: Implementation Determinants and Outcomes
Authors: McLoughlin Gabriella M , Allen Peg , Walsh-Bailey Callie , Brownson Ross C. 
Published: February 2021

Abstract
Background: Governments in some countries or states/provinces mandate school-based policies intended to improve the health and well-being of primary and secondary students, and in some cases the health of school staff. Examples include mandating a minimum time spent per week in programmed physical activity, mandating provision of healthy foods and limiting fat content of school meals, and banning tobacco products or use on school campuses. Although school health researchers have studied whether schools, districts, or states/provinces are meeting requirements, it is unclear to what extent implementation processes and determinants are assessed. The purposes of the present systematic review of quantitative measures of school policy implementation are to identify quantitative measures of implementation determinants and Proctor model implementation outcomes and assess pragmatic and psychometric properties of such measures.Methods: Peer-reviewed journal articles published 1995-2020 were included if they: 1) had multiple-item quantitative measures of school policy implementation; and 2) addressed overall wellness, tobacco, physical activity, nutrition, obesity prevention, and mental health/bullying/social-emotional learning. The final sample comprised 86 measurement tools from 67 peer-review articles. We extracted study characteristics, such as psychometric and pragmatic measure properties, from included articles based on three frameworks: Implementation Outcomes Framework, 2) Consolidated Framework for Implementation Research, and 3) Policy Implementation Determinants Framework.Results: Most implementation tools were developed to measure overall wellness policies which combined multiple policy topics (n=35, 40%) and were in survey form (n=75, 87%). Fidelity was the most frequently prevalent implementation outcome (n=70, 81%), followed by adoption (n=32, 81%). The implementation determinants most assessed were readiness for implementation, including resources (n=43, 50%), leadership (n=42, 49%), and policy communication (n=41, 48%). Overall, measures were low-cost and had easy readability. However, lengthy tools and lack of reported validity/reliability data indicate low transferability.Conclusions: Implementation science can contribute to more complete and rigorous assessment of school health policy implementation processes, which can improve implementation strategies and ultimately the intended health benefits. Several high-quality measures of implementation determinants and implementation outcomes can be applied to school health policy implementation assessment. D&I researchers can also benefit from measurement experiences of school health researchers.
Research on the Relationship Between Economic and Environmental Problems in Inner Mongolia under Industrial Transfer: An Analysis Based on EKC
Authors: Pei Xiaodong , Yuan Pengxu , Bao Chelimuge , Xue Junbo , Sun Ningning 
Published: February 2021

Abstract
In order to promote the economic development of the autonomous region, Inner Mongolia actively undertakes the industrial transfer in the eastern developed areas. In the process of promoting the economic development of Inner Mongolia, industrial transfer has also brought some environmental problems. In order to explore the relationship between industrial transfer, economic growth and the environment of Inner Mongolia, this paper selects the time series data of Inner Mongolia Autonomous Region from 2001 to 2016, and conducts an empirical analysis by establishing an Environmental Kuznets Curve (EKC) model. The study found that industrial transfer has brought the economic growth and the upgrading of industrial structure to Inner Mongolia, but also brought about environmental problems. Therefore, this paper proposes that Inner Mongolia should increase investment in R&D, strengthen investment in environmental governance, and make full use of the advantages of geography, labor force and natural resources to achieve high-quality economic development and industrial structure optimization and upgrade.