bluuebunny/crossref_metadata_2025_split huggingface dataset:
DDX58(RIG-I)-related disease is associated with tissue-specific interferon pathway activation
Authors: Prasov Lev , Bohnsack Brenda L , El Husny Antonette S , Tsoi Lam C , Guan Bin , Kahlenberg J Michelle , Almeida Edmundo , Wang Haitao , Cowen Edward W , De Jesus Adriana A , Jani Priyam , Billi Allison C , Moroi Sayoko E , Wasikowski Rachael , Almeida Izabela , Almeida Luciana N , Kok Fernando , Garnai Sarah J , Mian Shahzad I , Chen Marcus Y , Warner Blake M , Ferreira Carlos R , Goldbach-Mansky Raphaela , Hur Sun , Brooks Brian P , Richards Julia E , Hufnagel Robert B , Gudjonsson Johann E 
Published: January 2021

BackgroundSingleton-Merten syndrome (SGMRT) is a rare immunogenetic disorder that variably features juvenile open-angle glaucoma (JOAG), psoriasiform skin rash, aortic calcifications and skeletal and dental dysplasia. Few families have been described and the genotypic and phenotypic spectrum is poorly defined, with variants in DDX58 (DExD/H-box helicase 58) being one of two identified causes, classified as SGMRT2.MethodsFamilies underwent deep systemic phenotyping and exome sequencing. Functional characterisation with in vitro luciferase assays and in vivo interferon signature using bulk and single cell RNA sequencing was performed.ResultsWe have identified a novel DDX58 variant c.1529A>T p.(Glu510Val) that segregates with disease in two families with SGMRT2. Patients in these families have widely variable phenotypic features and different ethnic background, with some being severely affected by systemic features and others solely with glaucoma. JOAG was present in all individuals affected with the syndrome. Furthermore, detailed evaluation of skin rash in one patient revealed sparse inflammatory infiltrates in a unique distribution. Functional analysis showed that the DDX58 variant is a dominant gain-of-function activator of interferon pathways in the absence of exogenous RNA ligands. Single cell RNA sequencing of patient lesional skin revealed a cellular activation of interferon-stimulated gene expression in keratinocytes and fibroblasts but not in neighbouring healthy skin.ConclusionsThese results expand the genotypic spectrum of DDX58-associated disease, provide the first detailed description of ocular and dermatological phenotypes, expand our understanding of the molecular pathogenesis of this condition and provide a platform for testing response to therapy.
Model tests on biogrouted granular columns in soft soil
Authors: Mahawish Aamir , Bouazza Abdelmalek , Gates Will P. 
Published: January 2021

This paper examines the possible use of a bio-cementation process to reduce excessive bulging that occurs during the loading of granular columns in soft clays. A 12-phase percolation bio-chemical treatment technique was used to bio-cement part of the columns targeting the columns upper section, where bulging usually occurs. Upon application of unit cell surface loads up to 350 kPa, placement of a bio-cemented granular column substantially reduced the vertical strains by 43% to 48% compared with an un-cemented granular column and 56% to 60% compared with unreinforced kaolin clay for just a low replacement ratio of 11%. Bulging was reduced by 62% to 75% following bio-cementation and mostly occurred where bio-cementation was less evident. Scanning electron microscopy and energy dispersive spectroscopy validated the existence of calcium carbonate. This study presents a relatively new alternative to reducing bulging in granular columns using a promising approach.
GeV-scale neutrinos: interactions with mesons and DUNE sensitivity
Authors: Coloma Pilar , Fernández-Martínez Enrique , González-López Manuel , Hernández-García Josu , Pavlovic Zarko 
Published: January 2021

AbstractThe simplest extension of the SM to account for the observed neutrino masses and mixings is the addition of at least two singlet fermions (or right-handed neutrinos). If their masses lie at or below the GeV scale, such new fermions would be produced in meson decays. Similarly, provided they are sufficiently heavy, their decay channels may involve mesons in the final state. Although the couplings between mesons and heavy neutrinos have been computed previously, significant discrepancies can be found in the literature. The aim of this paper is to clarify such discrepancies and provide consistent expressions for all relevant effective operators involving mesons with masses up to 2 GeV. Moreover, the effective Lagrangians obtained for both the Dirac and Majorana scenarios are made publicly available as FeynRules models so that fully differential event distributions can be easily simulated. As an application of our setup, we numerically compute the expected sensitivity of the DUNE near detector to these heavy neutral leptons.
MS St. Petersburg RNL Yevr. II A 640: A Possible Remnant of Another Copy of Saadya Gaon’s Tafsīr by Samuel ben Jacob
Authors: Zewi Tamar 
Published: January 2021

Abstract
The article discusses one Genizah fragment from the Russian National Library in St. Petersburg, MS St. Petersburg RNL Yevr. II A 640, which contains a remnant of Saadya Gaon’s translation of the Pentateuch possibly copied by Samuel ben Jacob in the first quarter of the 11th century.
Tightening the Bonds between Edom and Israel (Gen 33:1–17*): On the Further Development of Edom’s Role within the Fortschreibung of the Jacob Cycle in the Exilic and Early Persian Periods
Authors: Hensel Benedikt 
Published: January 2021

Abstract
The article re-evaluates the role of Edom within the Jacob narrative and its formation processes. The bulk of the narrative stems from the pre-exilic period, supposedly the 8th century BCE. This article’s distinctive thesis is that Edom’s role undergoes certain developments during its Fortschreibung in the exilic and early Persian periods. The article will venture from the reconciliation scene in Gen 33:1–17*—the original ending of the earliest Jacob narrative—and describe the development of Edom’s role at different stages of its literary growth (e.g., the earliest Patriarchal narrative, the Abraham narrative, or within P). It will be observed that the strong and positive bond between Israel and Edom becomes even tightened within this process, which is remarkable because their relationship arguably worsened to a certain degree in the events accompanying the destruction of the Judahite kingdom. The article will investigate the historical realities behind this development.
Heretical Geometry
Authors: Jakušić Dino 
Published: January 2021

Abstract
This paper presents Christian Wolff’s claim that philosophy, undertaken on the basis of a proper method, cannot contradict revealed religion. The paper first provides a context of Wolff’s banishment from Halle for holding views in conflict with religious doctrines. Next, it proceeds, on the basis of Wolff’s Discursus præliminaris de philosophia in genere prefixed to his 1728 Latin Logic, to explain the principles of Wolff’s method, and to show how his conception of method enables him to disallow the possibility of a genuine conflict between philosophical and religious dogmas. For Wolff, doctrinal conflicts between philosophy and revealed religion can only occur as a result of terminological disagreements, disagreements between dogmas and hypotheses, or disagreements between dogmas and theological misinterpretations. The actual conflict of dogmas, understood as religious or philosophical truths, Wolff holds to be impossible.
Caspar Langenhert on Free Choice, Causation, and the Rejection of Calvinism
Authors: Jaworzyn Michael 
Published: January 2021

Abstract
This article provides an account of how Caspar Langenhert (1661–c. 1730) attempted to reconcile teaching a controversial “egoist” metaphysics in Paris with his reasons for rejecting Calvinism, leaving the Netherlands, and joining the Catholic Church. Langenhert had renounced Calvinism especially because he took the Calvinist account of free will to be philosophically, morally, and scripturally dubious. He preferred the notion of indifference in explaining freedom. That did not seem to accord well with his later work, the Novus Philosophus (1701–1702), whose supposedly “egoist” metaphysics appears to deny such freedom to creatures. Langenhert’s own defence would have been that there was no conflict here, because of the unusually strong distinction he drew between the domains of metaphysics and theology, but his attempts to sidestep his apparent unorthodoxy seem to have been unconvincing to the Parisian authorities, and Langenhert was required to cease teaching.
Five-Year Surveillance of Vitamin D Levels in NCAA Division I Football Players: Risk Factors for Failed Supplementation
Authors: Weber Alexander E. , Bolia Ioanna K. , Korber Shane , Mayfield Cory K. , Lindsay Adam , Rosen Jared , McMannes Sean , Romano Russ , Tibone James E. , Gamradt Seth C. 
Published: January 2021

Background: Monitoring vitamin D levels in athletes and determining their response to supplementation in cases of deficiency is thought to be necessary to modulate the risks associated with vitamin D deficiency. Hypothesis/Purpose: To report the results of a 5-year-long surveillance program of vitamin D in the serum of football players on a National Collegiate Athletic Association (NCAA) Division I team and to examine whether factors including age, body mass index (BMI), race, position played, and supplement type would affect the response to 12-month oral vitamin D replacement therapy in athletes with deficiency. We hypothesized that yearly measurements would decrease the proportion of athletes with vitamin D insufficiency over the years and that the aforementioned factors would affect the response to the supplementation therapy. Study Design: Cohort study; Level of evidence, 3. Methods: We measured serum 25(OH)D levels (25-hydroxyvitamin D) in 272 NCAA Division I football players from our institution annually between 2012 and 2017. Athletes with insufficient vitamin D levels (<32 ng/mL) received supplementation with vitamin D3 alone or combined vitamin D3/D2. The percentage of insufficient cases between the first 2 years and last 2 years of the program was compared, and yearly team averages of vitamin D levels were calculated. Associations between player parameters (age, BMI, race, team position, supplement type) and failed supplementation were evaluated. Results: The prevalence of vitamin D insufficiency decreased significantly during the study period, from 55.5% in 2012-2013 to 30.7% in 2016-2017 ( P = .033). The mean 25(OH)D level in 2012 was 36.3 ng/mL, and this increased to 40.5 ng/mL in 2017 ( P < .001); however, this increase was not steady over the study period. Non-Hispanic athletes and quarterbacks had the highest average 25(OH)D levels, and Black players and running backs had the lowest overall levels. There were no significant differences in age, BMI, race, or playing position between athletes with and without failed vitamin D supplementation. Athletes receiving vitamin D3 alone had a more successful rate of conversion (48.15%) than those receiving combined vitamin D3/D2 (22.22%; P = .034). Conclusion: To decrease the prevalence of vitamin D deficiency in football players, serum vitamin D measurements should be performed at least once a year, and oral supplementation therapy should be provided in cases of deficiency. Black players might be at increased risk of vitamin D insufficiency. Oral vitamin D3 may be more effective in restoring vitamin D levels than combined vitamin D3/D2 therapy.
Comparing the hippocampal miRNA expression profiles of wild and domesticated Chinese tree shrews (Tupaia belangeri chinensis)
Authors: Lu Caixia , Li Mingxue , Sun Xiaomei , Li Na , Wang Wenguang , Tong Pinfen , Dai Jiejie 
Published: January 2021

Abstract
Background
The domestication of tree shrews represents an important advance in the development of standardized laboratory animals. Little is known regarding the miRNA changes that accompany the transformation of wild tree shrews into domestic tree shrews.

Results
By performing miRNA-seq analysis on wild and domestic tree shrews, we identified 2410 miRNAs and 30 differentially expressed miRNAs in the hippocampus during tree shrew domestication. A KEGG analysis of the differentially expressed genes showed that the differentially expressed miRNAs were associated with ECM-receptor interaction, the phosphatidylinositol signaling system, protein digestion and absorption, inositol phosphate metabolism, lysine degradation, fatty acid degradation and focal adhesion. Most of these pathways could be classified under environmental information processing, organismal systems and metabolism. The miRNAs exclusively expressed in wild and tame tree shrews GO enriched in terms of divergent functions. The miRNA-mRNA networks suggested that novel-m1388-5p and novel-m0746-5p might play regulatory roles in domestication of tree shrews. Real–time RT-PCR analysis was employed to verify the presence of these miRNAs.

Conclusion
We identified a number of candidate miRNA-regulated domestication genes that may represent targets for selection during the domestication of tree shrews.
Cost-effectiveness of out-of-hospital continuous positive airway pressure for acute respiratory failure: decision analytic modelling using data from a feasibility trial
Authors: Thokala Praveen , Fuller Gordon W. , Goodacre Steve , Keating Samuel , Herbert Esther , Perkins Gavin D. , Rosser Andy , Gunson Imogen , Miller Joshua , Ward Matthew , Bradburn Mike , Harris Tim , Marsh Maggie , Ren Kate , Cooper Cindy 
Published: January 2021

AbstractBackgroundStandard prehospital management for Acute respiratory failure (ARF) involves controlled oxygen therapy. Continuous positive airway pressure (CPAP) is a potentially beneficial alternative treatment, however, it is uncertain whether this could improve outcomes and provide value for money. This study aimed to evaluate the cost-effectiveness of prehospital CPAP in ARF.MethodsA cost-utility economic evaluation was performed using a probabilistic decision tree model synthesising available evidence. The model consisted of a hypothetical cohort of patients in a representative ambulance service with undifferentiated ARF, receiving standard oxygen therapy or prehospital CPAP. Costs and quality adjusted life years (QALYs) were estimated using methods recommended by NICE.ResultsIn the base case analysis, using CPAP effectiveness estimates form the ACUTE trial, the mean expected costs of standard care and prehospital CPAP were £15,201 and £14,850 respectively and the corresponding mean expected QALYs were 1.190 and 1.128, respectively. The mean ICER estimated as standard oxygen therapy compared to prehospital CPAP was £5685 per QALY which indicated that standard oxygen therapy strategy was likely to be cost-effective at a threshold of £20,000 per QALY (67% probability). The scenario analysis, using effectiveness estimates from an updated meta-analysis, suggested that prehospital CPAP was more effective (mean incremental QALYs of 0.157), but also more expensive (mean incremental costs of £1522), than standard care. The mean ICER, estimated as prehospital CPAP compared to standard care, was £9712 per QALY. At the £20,000 per QALY prehospital CPAP was highly likely to be the most cost-effective strategy (94%).ConclusionsCost-effectiveness of prehospital CPAP depends upon the estimate of effectiveness. When based on a small pragmatic feasibility trial, standard oxygen therapy is cost-effective. When based on meta-analysis of heterogeneous trials, CPAP is cost-effective. Value of information analyses support commissioning of a large pragmatic effectiveness trial, providing feasibility and plausibility conditions are met.
Characteristics of hepatic solitary necrotic nodules on contrast-enhanced ultrasonography
Authors: Lu Chunyu , Tang Shaoshan , Zhang Xiaoyue , Wang Yang , Wang Kaiming , Shen Peng 
Published: January 2021

Abstract
Background
To summarize the characteristics of solitary necrotic nodules (SNN) in the liver observed under contrast-enhanced ultrasonography (CEUS).

Methods
Conventional ultrasonography (US) and CEUS were performed in 24 patients who were confirmed to have SNN by pathological assessment. The US data and dynamic enhancement patterns of CEUS were recorded and retrospectively analyzed.

Results
Ten of 24 patients underwent surgical resection, while the other 14 patients underwent a puncture biopsy to be confirmed as SNN. Among the 24 patients, 13 patients had a single lesion and 11 patients had multiple lesions. The largest lesion was selected for CEUS examination for patients with multiple lesions. Eleven patients presented no enhancement in all three phases, while the other 13 patients presented with a peripheral thin rim-like enhancement in the arterial phase, an iso-enhancement in the portal phase and delayed phase. However, no enhancement in the interior of the lesions was detected during three phases of CEUS.

Conclusions
SNN has characteristic findings on the CEUS, which play an important role in the differential diagnoses of liver focal lesions.
Prediction model study of overweight and obesity in preschool children with allergic diseases from an ecological perspective
Authors: Han Jeong-Won , Kim Da-Jung 
Published: January 2021

Abstract
Background
Allergic diseases have a high incidence in childhood and a high chance to be carried over into adulthood unless appropriately treated during childhood, it is important that healthcare providers actively manage these diseases. This study was to identify multidimensional factors that affect weight gain in preschool children with allergic diseases.

Methods
The overweight and obesity prediction model for children with allergic diseases was analyzed using multiple logistic regression analysis and a decision tree model and the present study was a secondary data analysis study that used data from the Panel Study on Korean Children conducted by the Korea Institute of Child Care and Education.

Results
The significance of this study is identify multidimensional factors that affect weight gain in preschool children with allergic diseases, which found that children (gender, sitting time during weekdays, sleeping hours during weekends,), parent (education level, mother’s job, quality of the home environment), local community (convenience of local community facilities, satisfaction level with local community facilities, quality of childcare in the local community) characteristics affected overweight and obesity at multidimensional levels as risk factors.

Conclusions
The significance of this study is identify multidimensional factors that affect weight gain in preschool children with allergic diseases using the data of the Panel Study on Korean Children, which found that children, parent, local community characteristics affected overweight and obesity at multidimensional levels as risk factors.
Masculinity and mental health treatment initiation for former political prisoners in Yangon, Myanmar – a qualitative investigation
Authors: Lakin Daniel P. , Win Kyaw Soe , Aung Htin , Soe Khin Nyein Chan , Kyi Bo , Marcell Arik V. , Tol Wietse A. , Bass Judith K. 
Published: January 2021

Abstract
Background
Men living in low- and middle-income countries are unlikely to seek mental health care, where poor healthcare infrastructure, differences in illness conceptualization, and stigma can impact treatment seeking. Vulnerable groups, such as former political prisoners, are more likely than others to experience potentially traumatic events that may lead to negative mental health outcomes. To improve the likelihood of successful engagement of vulnerable men in psychotherapy, it is necessary to identify factors that influence treatment adherence, and to better understand men’s attitudes surrounding decisions to seek and initiate care. The purpose of this investigation was to explore themes of masculinity, treatment seeking, and differences between male former political prisoners who accepted and declined therapy in an urban low-income context.

Methods
We conducted a qualitative, interview-based investigation with 30 former political prisoners in Yangon, Myanmar who were eligible to receive mental health counseling provided by the non-governmental organization (NGO), Assistance Association for Political Prisoners. Men were initially screened using a composite questionnaire with items related to depression, anxiety, and posttraumatic stress symptom severity. After screening, if potential clients were identified as having probable mental health problems, they were asked if they would like to participate in a multi-session cognitive behavioral therapy program. Semi-structured, open-ended interviews were conducted with 15 participants who accepted and 15 participants who declined therapy. Interviews were transcribed and translated by local partners and thematically coded by the authors. We used thematic analysis to identify and explore differences in treatment-seeking attitudes between men who accepted and men who declined the intervention.

Results
Men described that being a community leader, self-reliance, morality, and honesty were defining characteristics of masculinity. A focus on self-correction often led to declining psychotherapy. A general lack of familiarity with psychological therapy and how it differed from locally available treatments (e.g. astrologists) was connected to stigma regarding mental health treatment.

Conclusions
Masculinity was described in similar terms by both groups of participants. The interpretation of masculine qualities within the context of help-seeking (e.g. self-reliance as refusing help from others versus listening to others and applying that guidance) was a driving factor behind men’s decision to enter psychotherapy.
One‐level mini‐open pedicle subtraction osteotomy for treating spinal kyphosis in patients with ankylosing spondylitis
Authors: Wang Yu , Li Chunde , Liu Long , Qi Longtao 
Published: January 2021

Abstract
Background
To report a mini-open pedicle subtraction osteotomy (PSO) technique, to summarize the 2-year follow-up results of 25 patients, and to describe a modified operating table which allows the osteotomy to be closed in a more controllable manner.

Methods
We retrospectively reviewed the records of patients with AS who received one-level mini-open PSO between July 2015 and January 2018. The 25 patients with complete medical records and 2-year radiographic follow-up were included in the analysis. Estimated blood loss, operation time, incision length, complications, bed rest period, and length of hospitalization were extracted from the medical records and recorded.

Results
The mean age of the 25 patients (22 males and 3 females) was 39.5 years. The average global kyphosis(GK) decreased from 70.2° before surgery to 22.3° after surgery; the average C7- sagittal vertical axis (C7-SVA) decreased from 15.5 cm before surgery to 5.1 cm after surgery; the average pelvic incidence(PT) decreased from 37.8° before surgery to 22.5° after surgery. The average length of the incision was 10.2 cm. The average surgical time was 263.0 min, the average estimated blood loss was 840.0 ml, and the average time to mobilization was 4.1 days.

Conclusions
The current report shows that one-level PSO can be performed through an incision of about 10 cm. The one-level mini-open PSO could be superior to traditional PSO surgery with respect to cosmetic outcomes. Further comparative studies are necessary to evaluate the current and conventional techniques.