bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of Graft Maturity with Knee Function Scores Post Anterior Cruciate Ligament Reconstruction: A Retrospective Study
Authors: Chen Rongjin , Haozhong Zhu , Xinyi Gu , xianxiang xiang 
Published: September 2021

Abstract
BACKGROUND: The relationship between the signal/noise quotient value and knee function scores has not been extensively studied. Thus, we aimed to investigate the correlation between graft maturity and knee function after anterior cruciate ligament reconstruction.METHODS: In this retrospective study, we included patients (n=50; 28 male patients; age, 31.0 years) who underwent anterior cruciate ligament reconstruction with autogenous tendons between August 2016 and August 2018. At 6 months and 2 years postoperatively, the signal/noise quotient values of the tibia and femur, indicating graft maturity, were measured using magnetic resonance imaging. The Tegner, Lysholm, and International Knee Documentation Committee scores were used to evaluate knee function. Mean signal/noise quotient values of the grafts’ femoral and tibial ends were considered the final signal/noise quotient values. The correlation between the signal/noise quotient value at 6 months postoperatively and knee function score at 2 years postoperatively was analyzed. RESULTS: All patients were followed up for 24–28 months. The International Knee Documentation Committee, Lysholm, and Tegner scores of the knee joint at 6 months and 2 years postoperatively were significantly higher than the preoperative scores, and those at 2 years postoperatively were significantly higher than those at 6 months postoperatively. The signal/noise quotient value for all patients at 6 months postoperatively was negatively correlated with the Lysholm, International Knee Documentation Committee, and Tegner scores at 2 years postoperatively.CONCLUSION: The signal/noise quotient value based on magnetic resonance imaging in the early stage after anterior cruciate ligament reconstruction can predict knee function in the later stage.
Clinical outcomes of patients lost to follow-up and factors affecting follow-up loss after total knee arthroplasty
Authors: Yoon Jung-Ro , Park Phil Sun , Yoon Tae Hyuck , Lee Seung Hoon 
Published: September 2021

Abstract
Background
The hypotheses were as follows: 1) the clinical outcome of patients lost to follow-up after total knee arthroplasty (TKA) will be different compared to patients with follow-up; 2) follow-up rate will be affected by various social economic factors.
Methods
Patients who underwent TKA between March 2019 and February 2020 were retrospectively included. Patients lost to follow-up were defined as patients who did not undergo follow-up 6 months after TKA; all patients were divided into follow-up and follow-up loss groups. Western Ontario and McMaster Universities Osteoarthritis (WOMAC) and Knee Society Score (KSS) were measured before surgery. After surgery, WOMAC, KSS function, and satisfaction were measured via telephone. Age, sex, unilateral or bilateral TKA, distance from hospital, presence of a family, and insurance were investigated.
Results
A total of 137 patients were included in the study. There were 92 (67.2%) patients that followed up 6 months after TKA, on the other hand, 45 patients (32.8%) were lost to follow-up. There was no difference in clinical outcomes (WOMAC, p = 0.932; KSS clinical, p = 0.450) and satisfaction (pain: p = 0.230, function: p = 0.300) between two groups. Age, sex, unilateral or bilateral TKA, distance from hospital, presence of a family, and insurance had no effect on follow-up rates.
Conclusion
The clinical outcomes of patients lost to follow-up after TKA did not show a difference from those who were followed up. Age, sex, unilateral or bilateral TKA, distance from hospital, presence of a family, insurance status, and postoperative clinical symptoms did not affect the follow-up rate.
Optimization of the Image Contrast for the Developing Fetal Brain using 3D Radial VIBE Sequence in 3T Magnetic Resonance Imaging
Authors: Liao Yi , Li Xuesheng , Jia Fenglin , Ye Zhijun , Ning Gang , Liu Sai , Li Pei , Fu Chuan , Li Qing , Wang Shaoyu , Zhang Huapeng , Qu Haibo 
Published: September 2021

Abstract
Background: Faster and motion robust magnetic resonance imaging (MRI) sequences are desirable in fetal brain MRI. T1-weighted images are essential for evaluating fetal brain development. We optimized the radial volumetric interpolated breath-hold examination (VIBE) sequence for qualitative T1-weighted images of the fetal brain with improved image contrast and reduced motion sensitivity. Materials and Methods: This was an institutional review board-approved prospective study. Thirty-two pregnant subjects underwent fetal brain scan at 3 Tesla MRI. T1-weighted images were acquired using a 3D radial VIBE sequence with flip angles of 6º, 9º, 12º, and 15º and turbo FLASH (TFL) sequence. Qualitative assessments including image quality and motion artifact severity were evaluated. The image contrast ratio between gray and white matter were measured. Interobserver reliability and intraobserver repeatability were assessed using intraclass correlation coefficient (ICC).Results: Interobserver reliability and intraobserver repeatability universally revealed almost perfect agreement (ICC > 0.800). Significant differences in image quality were detected in basal ganglia (P < 0.001), central sulcus (P = 0.005), myelination (P < 0.001), lateral fissure (P = 0.008), optic chiasm (P < 0.001), and gray matter (P < 0.001) among radial VIBE with flip angles 6º, 9º, 12º, 15º and TFL groups. Image quality at the 9º flip angle in radial VIBE was generally better than TFL. Radial VIBE sequence with 9º flip angle of gray matter was significantly different by gestational age (GA) before and after 28 weeks (P = 0.036). Quantified image contrast was significantly different among protocols, consistent with qualitative analysis of image quality.Conclusions: Three-dimensional radial VIBE with 9º flip angle provides optimal, stable T1-weighted images of the fetal brain. Fetal brain structure and development can be evaluated using high-quality images obtained using this angle.
The evaluation of eazyplexÒ SuperBug CRE test usefulness for the detection of ESBLs and carbapenemases genes directly from urine samples and positive blood cultures
Authors: Sękowska Alicja , Bogiel Tomasz 
Published: September 2021

Abstract
Background. An increasing antimicrobial resistance of Gram-negative rods is an important diagnostic, clinical and epidemiological problem of a modern medicine. Therefore, it is important to detect multi-drug resistant strains as quickly as possible. The aim of this study was to evaluate eazyplex® SuperBug CRE test for beta-lactamases genes detection among Gram-negative rods, directly from urine samples and positive blood cultures. Methods. Eazyplex® SuperBug CRE test is based on isothermal amplification of a genetic material and allows for the detection of a selection genes encoding carbapenemases, i.e. KPC, NDM, VIM, OXA-48, OXA-181 and extended-spectrum beta-lactamases from the CTX-M-1 and CTX-M-9 groups. A total of 120 clinical specimens were included in the study. Results. The test gave valid results for 58 (96.7%) urine samples and 57 (95.0%) positive blood cultures. ESBL and/or carbapenemase enzymes genes were detected in 56 urine and 55 blood samples, respectively. Conclusions. Eazyplex® SuperBug CRE test can be used for a rapid detection of the most important genes encoded for resistance to beta-lactams in Gram-negative rods also without the necessity of bacterial culture.
Urinary Metabolomics Revealed the Biological Characteristics Associated with Early Pregnancy in Pigs
Authors: Zhou Chen , Cai Gengyuan , Meng Fanming , Hu Qun , Liang Guohao , Gu Ting , Zheng Enqin , Li Zicong , Wu Zhenfang , Hong Linjun 
Published: September 2021

Abstract
Background

Accurate early detection of pregnancy status is a prerequisite for effective monitoring of fertility in pig. In the early phase of pregnancy, because the embryo is small and in a free state, it is difficult to determine whether it is pregnant based on B-ultrasound examination. This calls for development of novel tools to accurately diagnose early pregnancy. Metabolomics reveal the metabolic status of cells, tissues and organisms.
Results

In this study, we investigated urinary metabolites in sows during early pregnancy. A total of 32 samples from 8 sows were collected at estrus and each phase of early pregnancy (days 9, 12, and 15 of gestation). Metabolites in urine samples from different sows obtained from gestation and estrus phases were analyzed via ultra-high performance liquid chromatography/mass spectrometry. A total of 530 metabolites were identified with high confidence in all samples. Compared with samples collected during the estrus phase, 269 differential metabolites were found in samples obtained during early pregnancy.
Conclusions

These metabolites included lipids and lipid-like molecules, organic acids and their derivatives, organic oxygen compounds, organoheterocyclic compounds, benzenoids, among others. These metabolites, such as choline and pregnanediol-3-glucuronide, play a very important role in pregnancy. They also regulate pregnancy in other animals. Our results provide novel insights into the metabolic changes in the urine of sows in the early pregnancy phase. The level of different metabolites in urine can be used to diagnosis pregnancy in sows. Understanding these metabolic changes is helpful for better management of pregnant sows.
Comparative analysis of neurological recovery and adverse effects in chondrodystrophic dogs with thoracolumbar intervertebral disc herniation treated with methylprednisolone versus non-steroidal anti-inflammatory drugs
Authors: McCartney William , Ober Ciprian Andrei , Benito Maria 
Published: September 2021

Abstract
Thoracolumbar intervertebral disc herniation is a common neurologic disease presented to the small-animal practitioner. The use of methylprednisolone sodium succinate (MPSS) as an adjunct to surgical decompression in cases of acute spinal cord injury following intervertebral disc extrusion is controversial. A prospective study was undertaken to compare the preoperative use of MPSS and non-steroidal anti-inflammatory drugs (NSAIDs) in 40 chondrodystrophic dogs presenting with similar signs and undergoing spinal decompressive surgery. Twenty dogs received MPSS and 20 had NSAIDs administered preoperatively. Dogs were administered with either MPSS intravenously 20 minutes before surgery (30 mg/kg) or NSAID (meloxicam 0.2mg/kg or carprofen 4 mg/kg) subcutaneously 20 minutes before surgery. Dogs were evaluated by neurologic examination of gait 24 hours postoperatively, at time of discharge and then at 8 weeks. The neurological recovery were similar in both groups, but the frequency of side effects such as vomiting (MPSS group: 90% versus NSAIDs group: 55%), and anorexia within the first three days (present in all 20 dogs pretreated with MPSS) was significantly different, with complications being more prevalent in the MPSS group. Side effects were significantly more evident with MPSS treatment group –including vomiting and anorexia during the first 3 days after surgery– than with NSAID treatment group, with a neurological recovery similar in both groups.
A novel rituximab administration protocol to minimize infusion-related adverse reactions in patients with B-cell non-Hodgkin lymphoma
Authors: Tsutsumi Daisuke , Hayama Tatsuya , Miura Katsuhiro , Uchiike Akihiro , Tsuboi Shinya , Otsuka Susumu , Hatta Yoshihiro , Kishikawa Yukinaga 
Published: September 2021

Abstract
Background

Rituximab is widely used as a key component of immunochemotherapy to treat B-cell non-Hodgkin lymphoma (B-NHL). However, infusion-related reactions (IRRs) during drug administration are occasionally severe or even life-threatening and thus remain problematic for patients and healthcare providers.
Aim

To minimize IRRs to rituximab in patients with various types of B-NHL.
Method:

We stratified patients into low- (n = 39), moderate- (n = 35), and high-risk (n = 7) groups according to the number of risk factors, specifically, an indolent histology and the presence of bulky tumors (> 10 cm). For the first rituximab cycle, the low- and moderate-risk groups underwent conventional infusion #1 (~ 4.3 h), and the high-risk group underwent long infusion (6.8 h). Patients in the low-, moderate-, and high-risk groups without IRRs in the first cycle underwent short infusion (2.3 h), conventional infusion #2 (3.5 h), and conventional infusion #1, respectively. Patients with IRRs in the first cycle received a second rituximab cycle with the same schedule as that in the first cycle. The procedure for the third cycle was at the attending physician’s discretion.
Results

Among 81 B-NHL patients, the incidences of IRRs in the low-, moderate-, and high-risk groups were 31%, 20%, and 57%, respectively, without any grade ≥ 3 IRRs. The overall conversion rate to short infusion in the third cycle was 54%, without any IRRs.
Conclusion

Our step-by-step protocol provided safe and comfortable rituximab administration for both patients and practitioners (UMIN-CTR; UMIN000032309, registered on 19th April 2018).
Advanced ventilatory support and mortality in hospitalized patients with COVID-19 caused by Gamma (P.1) variant of concern compared to other lineages: cohort study at a reference center in Brazil
Authors: Zavascki Alexandre Prehn , Vieceli Tarsila , Wink Priscila Lamb , Volpato Fabiana Caroline Zempulski , Monteiro Francielle Liz , Willig Julia Biz , Ferreira Charles Francisco , Arns Beatriz , Magalhães Guilherme Oliveira , Costa Matheus Niches , Martins Andreza Francisco , Barth Afonso Luís 
Published: September 2021

Abstract
Background

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variant of concern (VOC) Gamma (P.1) has increased transmissibility and resulted in elevated hospitalization, intensive care unit occupancy and mortality rates in Brazil. It is not known whether this VOC is also associated with more severe clinical course of disease.
Methods

This was a retrospective cohort study with non-elderly patients hospitalized for COVID-19 from June to December/2020 (first period) and February to May/2021 (second period) at a reference hospital in Brazil. Two cohorts were performed: the main cohort, composed by patients with SARS-CoV-2 lineages confirmed by whole genome sequencing; and the sensitivity cohort, composed by all eligible patients admitted before and after the emergence of Gamma. The primary outcome was the incidence rate of need of advanced ventilatory support.
Results

In the main cohort a total of 86 (43 Gamma and 43 non-Gamma) patients were included. Baseline characteristics were similar, except that Gamma patients had lower median Charlson’s comorbidity score. The crude and adjusted incidence rates of advanced respiratory support (adjusted Hazard Ratio [aHR], 1.78; 95% Confidence Interval [CI], 1.05–3.03), invasive respiratory support (aHR, 2.64; 95% CI, 1.34–5.19) and 28-day mortality from onset of symptoms (aHR, 4.73; 95% CI, 1.15–19.41) and adjusted 28-day mortality from hospital admission (aHR, 3.72; 95% CI, 1.19–11.65) were significantly higher in patients infected by Gamma. These patients had significantly lower days alive and free of supplemental oxygen support. The sensitivity cohort included 433 patients: 259 from the first and 174 from the second period (before and after the emergence of Gamma, respectively). Baseline characteristics were similar, except for a higher incidence of severe distress respiratory syndrome in patients from second group at admission. Patients from the second period had significantly higher incidence rates of advanced respiratory support (aHR, 2.04; 95% CI, 1.60–2.59), invasive ventilatory support (aHR, 2.72; 95%CI, 2.05–3.62), and 28-day mortality from the onset of symptoms (aHR, 2.62; 95%CI, 1.46–4.72).
Conclusions

Our study suggests that in non-elderly hospitalized patients, COVID-19 caused by Gamma VOC may present a more severe clinical course, with increased need of advanced respiratory support and higher 28-day mortality.
Molecular cytogenetics and St-chromosome-specific molecular markers development of novel stripe rust resistant wheat–Thinopyrum intermedium as well as wheat–Thinopyrum ponticum substitution lines
Authors: Wang Siwen , Wang Changyou , Feng Xianbo , Zhao Jixin , Deng Pingchuan , Wang Yajuan , Zhang Hong , Liu Xinlun , Li Tingdong , Chen Chunhuan , Wang Baotong , Ji Wanquan 
Published: September 2021

Abstract
Background
Owing to the excellent resistance to abiotic and biotic stress, Thionpyrum intermedium (2n = 6x = 42, JJJsJsStSt) and Thinopyrum ponticum (2n = 10x = 70) are both widely utilized in wheat germplasm innovation programs. Disomic substitution lines (DSLs) carrying one pair of alien chromosomes are valuable bridge materials for novel genes transmission, FISH karyotype construction and specific molecular marker development.
Results
Six wheat–Thinopyrum DSLs derived from crosses between Abbondanza nullisomic lines (2n = 40) and two octoploid Trititrigia lines (2n = 8x = 56), were characterized by a sequential fluorescence in situ hybridization (FISH)–genome in situ hybridization (GISH), a multicolor GISH (mc-GISH), and an analysis of wheat 15K SNP array combined with molecular marker selection. ES-9 (DS2St (2A)) and ES-10 (DS3St (3D)) are wheat–Th. ponticum DSLs, while ES-23 (DS2St (2A)), ES-24 (DS3St (3D)), ES-25(DS2St (2B)), and ES-26 (DS2St (2D)) are wheat–Th. intermedium DSLs. ES-9, ES-23, ES-25 and ES-26 conferred higher thousand-kernel weight and stripe rust resistance at adult stages, while ES-10 and ES-24 performed highly resistant to stripe rust at all stages. Furthermore, cytological analysis showed that the alien chromosomes (2St/3St) belonging to the same homoeologous group derived from different donors carried the same FISH karyotype and could normally form a bivalent. Based on specific-locus amplified fragment sequencing (SLAF-seq), two 2St-chromosome-specific markers (PTH-005 and PTH-013) and two 3St-chromosome-specific markers (PTH-113 and PTH-135) were developed.
Conclusions
The six wheat–Thinopyrum disomic substitution lines conferring stripe rust resistance will be used as bridging parents for valuable resistant genes transmission. And the utility of PTH-113 and PTH-135 in a BC1F2 population showed the newly developed markers could be useful tools for efficient identification of St chromosomes in a common wheat background.
Peran Lembaga Pengabdian dan Pengembangan Masyarakat (LP2M) Pesantren Al-Luqmaniyyah Yogyakarta dalam Mengurangi Masalah Krisis Keagamaan di Masyarakat Pelosok
Authors: Asari Aang , Charismanto Charismanto 
Published: September 2021

Penelitian ini berfokus pada salah satu kegiatan pengabdian yang telah terprogram setiap tahunnya di pondok pesantren Al-Luqmaniyyah Yogyakarta. Sasaran Pengabdian ini dikonsentrasikan pada daerah terpelosok yang dirasa masih membutuhkan pengembangan dan pemberdayaan. Khususnya mengenai pemahaman keagamaan masyarakat yang dinilai masih awam. Metode yang digunakan adalah metode kualitatif deskriptif. Penulis menceritakan hasil pengamatan dan pengalamannya serta dengan penelusuran dari data-data yang sudah didapat dari beberapa responden terkait. Pengambilan data pada penelitian ini menggunakan wawancara semi terstruktur dan observasi. Teknik analisis data dilakukan dengan cara reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa program tahunan Lembaga Pengabdian dan Pengembangan Masyarakat (LP2M) Pesantren Al-Luqmaniyyah yang dilaksanakan oleh santri-santri sebagai penggeraknya di lapangan, mampu untuk mengurangi krisis keagamaan di masyarakat. Selain itu pula dampak yang dirasakan masyarakat selaku objek dan santri sebagai subjek dari Lembaga Pengabdian dan Pengembangan Masyarakat ini bisa dirasakan oleh seluruh pihak terkait. Lembaga pengabdian dan pengembangan pondok pesantren ini juga masih tetap eksis dari awal berdiri hingga saat ini. This research focuses on one of the yearly programmed service activities at the Al-Luqmaniyyah Yogykarta Islamic boarding school. This Community Service target focuses on remote areas that still need development and empowerment. Especially regarding the religious understanding of the community which is still common. The method used is descriptive qualitative method. The author tells the results of his observations and experiences and also presents the results of tracing data obtained from several related respondents. The data collection process in this research used semi-structured interviews and observations. The data analysis technique was carried out by means of data reduction, data presentation, and drawing conclusions. The results showed that the annual program of the Institute for Community Service and Development (LP2M) of Al-Luqmaniyyah Islamic Boarding School which was implemented by the students as a driving force was able to reduce the religious crisis in society. In addition, the impact felt by the community as objects and students as subjects of this Community Service and Development Institute can be felt by all parties involved. This institution also still exists today.
Improving the ZnO-photocatalytic degradation of humic acid using powdered residuals from water purification plant
Authors: Elmougi Mohamed , El-Etriby Hisham , Barakat Ragab , Alalm Mohamed Gar , Mossad Mohamed 
Published: September 2021

Abstract
Alum residuals were collected from a water treatment plant and used for improving the photocatalytic degradation of humic acid (HA) by combinations of zinc oxide (ZnO) and powdered residuals from a water purification plant (PRWPP). The influence of operating conditions such as initial humic acid concentration, pH, irradiation time, PRWPP to ZnO ratio, catalyst dose, and light illuminance have been investigated. The optimum PRWPP to ZnO ratio was 10:90. Using the prepared composites instead of bare ZnO raised the HA removal efficiency from 85.5% to 97.8%, and from 38% to 48.1% at catalyst doses of 1.2 g/l and 0.4 g/l, respectively. Moreover, it reduced energy consumption from 210.4 to 166.2 Wh per mg of HA. An artificial neural network model (ANN) was developed to predict the removal efficiency under different operating conditions. The optimum ANN structure yielded a coefficient of determination (R2 = 0.993). A modified Langmuir-Hinshelwood pseudo-first-order model was used for describing the degradation kinetics at different initial concentrations of HA.
Optimization of pipeline lifecycle cost using alternatives with different life spans
Authors: Elsebaie Ibrahim H. , Al-Khomairi Abdulrahman 
Published: September 2021

Abstract
This paper suggests a pipeline project optimization approach that compares alternatives with different life spans. The average inflation rate is used to project the future maintenance, operation and replacement costs. The average interest rate is used to express all the costs in Equivalent Real Annual Cost (ERAC), which is the correct cost form to compare alternatives with different life spans. The pipe diameter, material, pressure rating, surge tank size, and inlet/outlet resistances are the decision variables. A software was compiled with a commercial pipeline software to generate all the possible design alternatives based on the decision variables. Pipe initial cost as well as operation and maintenance costs are computed for each design alternative. The alternative with the least ERAC value is the optimum one. It was found that the approach can lead to substantial savings in pipeline projects cost. For pipes 800 mm in diameter or larger, and when selecting the optimum diameter, savings are between 23 and 27% in the total project cost. When imposing certain pipe material savings in overall cost will be 8.5, 16.3 and 31.3% for ductile iron, GRP and mild steel pipe material, respectively.