bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vivo examination of healthy human skin after short‐time treatment with moisturizers using confocal Raman spectroscopy and optical coherence tomography: Preliminary observations
Authors: Ruini Cristel , Kendziora Benjamin , Ergun Ecem Z. , Sattler Elke , Gust Charlotte , French Lars E. , Bağcı Işın Sinem , Hartmann Daniela 
Published: September 2021

AbstractSkin is our barrier against environmental damage. Moisturizers are widely used to increase hydration and barrier integrity of the skin; however, there are contrasting observations on their in vivo effects in real‐life settings. In cosmetic studies, corneometers and tewameters are traditionally used to assess skin hydration. In this study, two novel noninvasive diagnostic techniques, optical coherence tomography (OCT) and confocal Raman spectroscopy, were used to analyze stratum corneum and epidermal thickness (ET), water content, blood flow in function of depth, skin roughness, attenuation coefficient, natural moisturizing factor, ceramides and free fatty acids, cholesterol, urea, and lactates in 20 female subjects aged between 30 and 45 before and after 2 weeks application of a commercially available moisturizing lotion on one forearm. The untreated forearm served as control. A third measurement was conducted 1 week after cessation of moisturizing to verify whether the changes in the analyzed parameters persisted. We noticed a reduction in skin roughness, an increase in ceramides and free fatty acids and a not statistically significant increase in ET. As a conclusion, short time moisturizing appears insufficient to provide significant changes in skin morphology and composition, as assessed by OCT and RS. Novel noninvasive imaging methods are suitable for the evaluation of skin response to topical moisturizers. Further studies on larger sample size and longer treatment schedules are needed to analyze changes under treatment with moisturizers and to standardize the use of novel noninvasive diagnostic techniques.
Balloon expandable aortic stent‐graft for the treatment of aortic aneurysm and rupture in a dog
Authors: Klainbart Sigal , Segev Gilad , Chen Hilla , Peery Dana , Shipov Anna 
Published: September 2021

AbstractObjectiveTo describe the successful placement of an aortic stent graft in a dog suffering from aortic aneurysm and rupture.Case summaryA 4‐year‐old neutered female mixed breed dog weighing 25 kg was presented with a chief complaint of acute onset of weakness and respiratory distress. On presentation, the dog was lateral and unresponsive, hypothermic, tachycardic, and tachypneic. Pleural effusion was identified in the right hemi‐thorax on thoracic‐focused sonographic scan for trauma. Thoracic radiographs showed a fluid/soft tissue opacity in the cranial mediastinum and pleural effusion on the right side. Thoracocentesis yielded noncoagulating blood. Hematology revealed normal PCV and total plasma protein that decreased within 24 hours to 20% and 50 g/L (20%/5.0 g/dL), respectively. The dog was treated with IV fluids, tranexamic acid, and fresh frozen plasma. An aortic aneurysm with irregular mineralization of the right ventrolateral aortic wall was identified on computed tomography examination, which also demonstrated a peri‐aortic hematoma. A decision was made to attempt treatment with a stent graft. Under general anesthesia, a marker catheter was inserted into the esophagus. A 10‐Fr sheath was inserted into the right femoral artery, and an angiography catheter was advanced over a wire. After angiography, a stent graft (12‐mm × 50‐mm) was placed over the guide wire and deployed under fluoroscopic guidance. The dog recovered uneventfully, with no evidence of recurrent bleeding, and was discharged 2 days after the procedure with antimicrobials, anthelmintic, and antithrombotic treatment. At 90‐day follow‐up, the dog was doing well, and stent position was radiographically confirmed.New or unique information providedThis report describes successful management of aortic aneurysm and dissection, an uncommon and challenging pathology in the veterinary practice with few available treatment options. Stent graft placement is a minimally invasive procedure in which a covered stent is placed over the lesion to prevent rupture.
Clinical comparison of tear film breakup time measurements in normal dogs using three different methods of fluorescein solution administration
Authors: Palmer Samantha , Ramos Renata V. , Rodriguez Galarza Roxanne M. 
Published: September 2021

AbstractObjectiveTo evaluate whether the method of fluorescein administration affects the results of tear film breakup time (TFBUT) measurement in normal dogs.Animals studiedThirty‐seven client and hospital staff owned dogs over 1 year of age with no known comorbidities or administration of systemic or topical ophthalmic medications.ProceduresA prospective randomized three‐way crossover study was conducted. All dogs received an abbreviated ophthalmic examination to rule out ocular surface disease. Using a 30‐min washout interval period, each dog's right eye was received: (a) direct application of fluorescein stain strip with one drop of sterile eyewash, (b) direct application of fluorescein stain strip with two drops of sterile eyewash, or (c) application of one drop from a premade fluorescein solution (dilution of one strip in 0.3 mL sterile eyewash). Eyes were assessed using the cobalt blue filter of a slit lamp biomicroscope. TFBUT measurements were summarized as means ± standard deviation. The methods were compared using mixed model analysis of variance. All analyses were performed using sas version 9.4.ResultsThirty‐seven dogs met the inclusion criteria. Mean TFBUT ± standard deviation (SD) for the three described methods were: (a) 16.58s ± 6.9, (b) 15.98s ± 7.1, and (c) 16.43s ± 8.1. No differences between fluorescein stain application techniques were observed (p = .92).ConclusionThe technique of fluorescein solution administration did not affect TFBUT measurement in this population of healthy dogs.
Humanization of care for adult ICU patients: a scoping review protocol
Authors: Gareau Stéphanie , de Oliveira Élaine Machado , Gallani Maria Cecilia 
Published: September 2021

ABSTRACT

Objective:
The objective of this review is to review and map data from studies on the humanization of care in intensive care units based on a conceptual framework.

Introduction:
The critical context of adult patients in intensive care units directs the focus on clinical medical interventions, drawing attention away from the humanization of care. Rethinking intensive care is imperative and the humanization of care is an absolute priority. Literature on this topic is scattered under umbrella terms such as “patient-centered care” or specific terms referring to target interventions. A scoping review based on a conceptual framework will map the literature on humanization in intensive care units.

Inclusion criteria:
The review will consider studies on the humanization of care, or on one of the seven components of the conceptual framework (communication, visiting hours, patients’ and health care professionals’ well-being, family involvement and satisfaction, post–intensive care unit syndrome, and physical environment) focusing on adult patients in intensive care units. Studies on co-existing states or end-of-life care will be excluded.

Methods:
A search of Embase, PubMed, and CINAHL will be conducted to identify relevant studies in English or French on the humanization of care, holistic care, or person-centered care in an adult intensive-care environment. The time period covered will be January 1, 2010 to the present. An iterative team approach will be used to screen and select studies and extract data. Data will be charted according to study design, distribution in time, cultural context, concepts, use of theoretical models, and intervention. The results will be summarized and reported, identifying the implications for policy, practice, and research.
Accuracy of imaging modalities at detecting extracapsular spread of cervical lymph node metastases in HPV-associated oropharyngeal cancer: a systematic review protocol of diagnostic test accuracy
Authors: Morey Tristan , Stern Cindy , Foreman Andrew , Hodge John-Charles 
Published: September 2021

ABSTRACT

Objective:
The objective of this review is to evaluate the accuracy of different imaging modalities in detecting extracapsular spread (ECS) of cervical lymph node metastases in human papillomavirus positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC).

Introduction:
Extracapsular spread of lymph node metastases is associated with poor prognosis, and its detection in head and neck cancer is crucial for treatment planning. Commonly used imaging modalities to detect ECS in OPSCC include computed tomography, magnetic resonance imaging, positron emission tomography, and ultrasonography. Currently there is no gold standard imaging modality to detect ECS in OPSCC.

Inclusion criteria:
This review will consider published studies examining the diagnostic accuracy (including sensitivity and specificity) of an imaging modality used to detect ECS in HPV+ OPSCC. Participants will have a diagnosis of HPV+ OPSCC and suspected diagnosis of ECS of cervical lymph node metastases. The index test will be different imaging modalities used to detect ECS, and the reference test will be histopathology.

Methods:
A three-step search strategy will be undertaken to identify relevant studies in MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and Scopus. A standardized critical appraisal tool (QUADAS-2) will be used to assess the methodological quality of the studies. The main outcomes will be sensitivity and specificity measures reported with 95% confidence intervals. Meta-analysis will be conducted using a bivariate model approach after pooling the studies according to imaging modality. Meta-regression will be used to explore heterogeneity. Meta-regression and subgroup analyses will be used to compare studies and imaging modalities. The results will be presented using either paired forest plots, summary receiver operator characteristic curves, or a narrative synthesis. A GRADE Summary of Findings will be provided.

Systematic review registration number:
PROSPERO CRD42021250626
Sub‐maximal aerobic exercise training reduces haematocrit and ameliorates symptoms in Andean highlanders with chronic mountain sickness
Authors: Macarlupú José Luis , Vizcardo‐Galindo Gustavo , Figueroa‐Mujíca Rómulo , Voituron Nicolas , Richalet Jean‐Paul , Villafuerte Francisco C. 
Published: September 2021

New Findings

What is the central question of this study?
What is the effect of sub‐maximal aerobic exercise training on signs and symptoms of chronic mountain sickness (CMS) in Andean highlanders?

What is the main finding and its importance?
Aerobic exercise training (ET) effectively reduces haematocrit, ameliorates symptoms and improves aerobic capacity in CMS patients, suggesting that a regular aerobic ET programme might be used as a low‐cost non‐invasive/non‐pharmacological management strategy of this syndrome.

AbstractExcessive erythrocytosis is the hallmark sign of chronic mountain sickness (CMS), a debilitating syndrome associated with neurological symptoms and increased cardiovascular risk. We have shown that unlike sedentary residents at the same altitude, trained individuals maintain haematocrit within sea‐level range, and thus we hypothesise that aerobic exercise training (ET) might reduce excessive haematocrit and ameliorate CMS signs and symptoms. Eight highlander men (38 ± 12 years) with CMS (haematocrit: 70.6 ± 1.9%, CMS score: 8.8 ± 1.4) from Cerro de Pasco, Peru (4340 m) participated in the study. Baseline assessment included haematocrit, CMS score, pulse oximetry, maximal cardiopulmonary exercise testing and in‐office plus 24 h ambulatory blood pressure (BP) monitoring. Blood samples were collected to assess cardiometabolic, erythropoietic, and haemolysis markers. ET consisted of pedalling exercise in a cycloergometer at 60% of for 1 h/day, 4 days/week for 8 weeks, and participants were assessed at weeks 4 and 8. Haematocrit and CMS score decreased significantly by week 8 (to 65.6 ± 6.6%, and 3.5 ± 0.8, respectively, P < 0.05), while and maximum workload increased with ET (33.8 ± 2.4 vs. 37.2 ± 2.0 ml/min/kg, P < 0.05; and 172.5 ± 9.4 vs. 210.0 ± 27.8 W, P < 0.01; respectively). Except for an increase in high‐density lipoprotein cholesterol, other blood markers and BP showed no differences. Our results suggest that reduction of haematocrit and CMS symptoms results mainly from haemodilution due to plasma volume expansion rather than to haemolysis. In conclusion, we show that ET can effectively reduce haematocrit, ameliorate symptoms and improve aerobic capacity in CMS patients, suggesting that regular aerobic exercise might be used as a low‐cost non‐invasive and non‐pharmacological management strategy.
Study on Design Method of Combustion Reference Values for Model-Based Control of Advanced Diesel Engine
Authors: Kim Jihoon , Yamasaki Yudai 
Published: September 2021

Abstract
Model-based control systems are drawing attention in relation to implementing advanced combustion technologies with high thermal efficiency and low emissions, such as homogeneous charge compression ignition and premixed charge compression ignition combustion, having low robustness. A model-based control system for engine combustion derives control inputs based on reference values and operating conditions in each cycle. Thus, it can replace the conventional control map, which necessitates a significant number of experiments. However, model-based control for combustion requires reference values, such as heat-release-rate peak timing and value, which represent the combustion state. In addition, because model-based control systems derive control inputs cycle by cycle, the combustion reference for the transient condition is critical for maximizing the benefit of such systems. Therefore, this study describes a design method of the combustion reference values for transient operation. The combustion method targeted in this study is a premixed compression ignition combustion that exhibits two-stage heat releases and can reduce combustion noise. Particularly, a method using predicted future operating conditions considering the driving characteristics is proposed. Designed combustion reference values with the proposed method were evaluated with engine control experiments in a certain part of worldwide harmonized light vehicles test cycle. Results indicate that the rate of achieving the desired two-stage heat releases combustion improved from 57% to 81% and combustion noise reduced. Thus, designing the combustion reference values for transient operation by considering future operating conditions is effective to ensure advanced combustion. In addition, such a method can consider the driving characteristics.
A Finite Element Model for the Prediction of Chip Formation and Surface Morphology in Friction Stir Welding Process
Authors: Das Debtanay , Bag Swarup , Pal Sukhomay , Amin M Ruhul 
Published: September 2021

Abstract
Friction stir welding (FSW) is widely recognized green manufacturing process capable of producing good quality welded joints at a temperature lower than the melting point. However, most of the works are focused on the establishment of the process parameters for a defect-free joint. There is a lack to understand the formation of defects from a physical basis and visualization of the same, which is otherwise difficult to predict by means of simple experiments. The conventional models do not predict chip formation and surface morphology by accounting for the material loss during the process. Hence, a three-dimensional (3D) finite element-based thermomechanical model is developed following coupled Eulerian-Lagrangian (CEL) approach to understand surface morphology by triggering material flow associated with tool–material interaction. In the present quasi-static analysis, the mass scaling factor is explored to make the model computationally feasible by varying the FSW parameter of plunge depth. The simulated results are validated with experimentally measured temperature and surface morphology. In the CEL approach, the material flow out of the workpiece enables the visualization of the chip formation, whereas small deformation predicts the surface quality of the joint.
Power Generation and Oxygen Transfer Analyses for Micro Hydro-Turbine Installed in Wastewater Treatment Aeration Tank
Authors: Salem Abdel Rahman , Hasan Alaa , Hadi Ahmad Abdel , Al Hamad Saif , Qandil Mohammad , Amano Ryoichi S. 
Published: September 2021

Abstract
This study targets one of the major energy consumers in the U.S. It suggests a new mechanical system that can recover a portion of the energy in Wastewater Treatment Plants (WWTPs). The proposed system entails a hydro-turbine installed above the air diffuser in the aeration tank to extract the water-bubble current’s kinetic energy and converts it to electricity. Observing the optimum location of the turbine required multiple experiments where turbine height varies between 35% and 95% (water height percentages above the diffuser), while varying the airflow between 1.42 L/s (3 CFM) and 2.12 L/s (4.5 CFM) with a 0.24 L/s (0.5 CFM) increment. Additionally, three water heights of 38.1 cm (15″), 53.4 cm (21″), and 68.6 cm (27″) were considered to study the influence of the water height. It was noticed that the presence of the system has an adverse effect on the standard oxygen transfer efficiency (SOTE). Therefore, a small dual-blade propeller was installed right above the diffuser to directly mix the water in the bottom of the tank with the incoming air to enhance the SOTE. The results showed that the maximum reclaimed power was obtained where the hydro-turbine is installed at 65–80% above the diffuser. A reduction of up to 7.32% in SOTE was observed when the setup was placed inside the tank compared to the tank alone. The addition of the dual-blade propeller showed an increase in SOTE of 7.27% with a power loss of 6.21%, ensuring the aeration process was at its standards.
Optimizing Power Reclamation of Micro Hydro Turbines in WWTPs Aeration Basins
Authors: Hasan Alaa , Salem Abdel Rahman , Abdelhadi Ahmad , Al Hamad Saif , Qandil Mohammad , Amano Ryoichi S. 
Published: September 2021

Abstract
This study investigates the optimum operating conditions and design configurations that can optimize the power reclaimed by small hydro turbines derived by the rising water-bubble current. The rising current is generated by the compressed air introduced by the diffusers at the bottom of aeration basins of Wastewater Treatment Plants (WWTPs). While optimizing the power production, the standard oxygen transfer efficiency (SOTE) is monitored since it is a significant parameter that cannot be sacrificed in the operation of WWTPs. Using one set of turbine blades, it was found out that the highest velocity is obtained in the upper half of the water column (70% - 80%). In contrast, the lowest velocities were obtained just above the air diffuser and at the water surface. Testing started with using a single turbine (ST) to determine the location of the optimum power reclaimed at each tested airflow (1.18, 1.42, 1.65, and 1.89 L/s). Then using double turbine (DT) and triple turbine (TT) to compare their performance to the ST&#x92;s maximum power increased power reclamation. The maximum percentage of increase in power reclamation for DT is 19.59%, while it is 20.24% in the case of TT. At a commonly used airflow in WWTPs (1.42 L/s), the optimum configurations of DTs and TTs were selected to investigate the effect of having the proposed setup on the SOTE. For membrane diffusers, DTs and TTs limited the dispersion of the air bubbles in the tank, therefore, reducing the SOTE (8.3% for DT and 3.7% for the TT). The ceramic and sharp-nub diffusers were also tested versus rubber membrane ones to determine the effect of using the ceramic and sharp-nub diffusers on the power reclamation and SOTE. Ceramic diffusers neither achieve higher power reclamation than the membrane nor increases the SOTE. In contrast, sharp-nub diffusers increase the SOTE for all configurations compared to membranes, but this came into account of power reclamation, where sharp-nub diffusers cause a DT and a TT to produce less power than ST does.
Assessment of Renewable Natural Gas Refueling Stations for Heavy-Duty Vehicles
Authors: Yaïci Wahiba , Longo Michela 
Published: September 2021

Abstract
With environmental concerns and limited natural resources, there is a need for cleaner sources of energy in the transportation sector. Renewable natural gas (RNG) is being considered as a potential fuel for heavy-duty applications due to its comparable usage to diesel and gasoline in vehicles. The idea of compressed RNG vehicles is being proposed especially because it will significantly reduce harmful emissions into the environment. This study examines the feasibility of implementing a nationwide network of compressed RNG refueling infrastructure in order to accommodate a conversion of long-haul, heavy-duty (LHHD) truck fleet from diesel fuel to RNG. Two methods, Constant Traffic and Variable Traffic, along with data about compressed RNG infrastructure and vehicles, were developed and used to predict fuelling requirements for LHHD truck fleet. Then, a detailed economic analysis was conducted on various test cases to estimate how different variables impact the final selling price of RNG. This provided insight with the understanding of what factors go into pricing RNG and if it can compete against diesel in the trucking market. Results disclosed that the cost to purchase RNG is the greatest factor in the final selling price of compressed RNG. Due to the variability in RNG production, however, there is no precise cost, which makes predictions challenging. However, results revealed that it is possible for compressed RNG to be competitive with diesel, with the mean compressed RNG price being 16.5% cheaper than diesel, before being taxed. Future studies should focus on the feasibility of the production of RNG and the associated costs. An in-depth analysis on operational and maintenance costs for compressed RNG refueling stations may also provide predictions that are more accurate. The methodology developed in this feasibility analysis may serve as a useful tool for future techno-economics of RNG refueling stations for other types of internal combustion engine (ICE) fleets or those powered with alternative green fuels.
Performance Analysis of Solar Thermal Powered Supercritical Organic Rankine Cycle-Assisted Low-Temperature Multi-Effect Desalination Coupled With Mechanical Vapor Compression
Authors: Almatrafi Eydhah , Moloney Francesca , Goswami D. Y. 
Published: September 2021

Abstract
Power and freshwater demand are increasing as populations around the world keep growing. Due to the environmental impact of using fossil fuels and limited resources, using solar thermal in desalination application is a valuable option. In this paper, an innovative new design of low-temperature multi-effect desalination coupled with mechanical vapor compression (LT-MED-MVC) powered by supercritical organic Rankine cycle (SORC) utilizing a low-grade solar heat source using evacuated tube collectors is analyzed. The proposed design has the potential to desalinate water of high salt concentrations or brine with high salinity more than 100,000 ppm or effluent streams from a power plant with low energy consumption and high efficiency when compared to other systems. The performance of the LT-MED-MVC was found to be better than similar systems found in the literature. The specific power consumption for the system is lower than 4 kW h/m3 for seawater feed salinity of 100,000 ppm, 14 forward feed effects, and a recovery rate of 50%. The overall system efficiency is about 14%. The impact of increasing the number of effects, motive steam temperature, pressure of SORC, and salt concentration on the specific power consumption, solar collector area, and the system efficiency are also analyzed.