bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climate change research and action must look beyond 2100
Authors: Lyon Christopher , Saupe Erin E. , Smith Christopher J. , Hill Daniel J. , Beckerman Andrew P. , Stringer Lindsay C. , Marchant Robert , McKay James , Burke Ariane , O’Higgins Paul , Dunhill Alexander M. , Allen Bethany J. , Riel‐Salvatore Julien , Aze Tracy 
Published: September 2021

AbstractAnthropogenic activity is changing Earth's climate and ecosystems in ways that are potentially dangerous and disruptive to humans. Greenhouse gas concentrations in the atmosphere continue to rise, ensuring that these changes will be felt for centuries beyond 2100, the current benchmark for projection. Estimating the effects of past, current, and potential future emissions to only 2100 is therefore short‐sighted. Critical problems for food production and climate‐forced human migration are projected to arise well before 2100, raising questions regarding the habitability of some regions of the Earth after the turn of the century. To highlight the need for more distant horizon scanning, we model climate change to 2500 under a suite of emission scenarios and quantify associated projections of crop viability and heat stress. Together, our projections show global climate impacts increase significantly after 2100 without rapid mitigation. As a result, we argue that projections of climate and its effects on human well‐being and associated governance and policy must be framed beyond 2100.
Impact of foreign direct investment on the haze pollution in various cities: Evidence from China
Authors: Huang Dan , Zhong Shihu , Tang Juan , Zhao Jingjing 
Published: September 2021

AbstractThis study employs panel data of 270 Chinese cities at the prefecture level or above from 2004 to 2018 to examine the impact of foreign direct investment (FDI) on urban haze pollution and its mechanism. The heterogeneity in FDI's impact in cities with different size, development level, government regulation level, the opening degree of the market, and government capacity is also investigated. The results show FDI exacerbates haze pollution in Chinese cities. At the mean value of the samples, a 1% rise in FDI would increase PM2.5 by approximately 0.0073%. These results remain consistent after we experiment several robustness checks. Then, analysis of mechanism suggests that FDI impacts PM2.5 via scale effect, composition effect and technological innovation effect. Finally, heterogeneity analysis further demonstrates haze pollution is more sensitive to the change of FDI in cities with low development level, cities with low market openness, and cities with weak government capacity. Further, it is worth stressing that FDI increases haze pollution in small‐, medium‐, and large sized cities, while it reduces haze pollution in mega cities and above. Moreover, the scale effect, composition effect, and technology effect of FDI in different cities are varied. Policy implications of our work are discussed.
Effects of Bacillus velezensis zk1 on the physiology and metabolism of peaches
Authors: Zeng Yaoying , Yu Qian , Cheng Shujun 
Published: September 2021

SummaryBacillus velezensis zk1 is the dominant bacterium that causing rot in peaches. However, the mechanisms through that this bacterium causes rot have not been elucidated. Here, we explored the mechanisms of peach decay caused by B. velezensis zk1. The invasion of B. velezensis zk1 in peaches resulted in an increase in glucose and arabinose contents in fruit tissues. Moreover, the relative conductivity of the fruit reached 84% after 4 days of culture with bacterial invasion. With the destruction of cells, the malondialdehyde content increased, whereas the vitamin C, dialdehyde, flavonoid and total phenol contents decreased. Polyphenol oxidase, superoxide dismutase, catalase, peroxidase, ascorbate peroxidase and ammonia lyase activities also decreased. Overall, these findings demonstrated that B. velezensis zk1 infection damaged peach chloroplasts, mitochondria, respiratory chain activity and related free radical scavenging enzyme systems, thereby disrupting the normal physiological metabolism of peaches and causing rot.
Effect of nitrate reduction and storage time on the antioxidative properties, biogenic amines and amino acid profile of dry fermented loins
Authors: Karwowska Małgorzata , Kononiuk Anna D. 
Published: September 2021

SummaryThe aim of this work was to evaluate the effect of nitrate reduction and storage time on the content of amino acids and biogenic amines (BAs), total antioxidant capacity (TAC) and antioxidative properties of peptides isolated from dry fermented loins. The results showed that reducing the addition of nitrates increased the amount of BAs formed during storage of dry fermented loins. The lowest TAC value (tested by ABTS assay) was recorded for the sample with the highest nitrate addition (150 mg kg‐1) at beginning, while the highest value was noted for the sample without nitrate addition at 180 days of storage. The amino acid profile showed that dry fermented loin with the highest addition of nitrate was characterised by a significantly lower content of amino acids, which are precursors of key aroma compounds compared with loin samples with a lower amount of added sodium nitrate. The sum of ranking differences (SRD) indicated that loin sample with traditional addition of nitrate (150 mg kg‐1) after 120 days of storage was characterised by the lowest SRD result, which means that they are the closest to the assumed values, that is the lowest content of BAs, the highest antioxidant activity and amino acid patterns recommended by WHO/FAO/UNU Experts.
Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases
Authors: Liang Hong‐Yu , Chen Yong , Wei Xin , Ma Gang‐Gang , Ding Jie , Lu Chao , Zhou Ren‐Peng , Hu Wei 
Published: September 2021

AbstractAn autoimmune disease is an inappropriate response to one's tissues due to a break in immune tolerance and exposure to self‐antigens. It often leads to structural and functional damage to organs and systemic disorders. To date, there are no effective interventions to prevent the progression of autoimmune diseases. Hence, there is an urgent need for new treatment targets. TRPM7 is an enzyme‐coupled, transient receptor ion channel of the subfamily M that plays a vital role in pathologic and physiologic conditions. While TRPM7 is constitutively activated under certain conditions, it can regulate cell migration, polarization, proliferation and cytokine secretion. However, a growing body of evidence highlights the critical role of TRPM7 in autoimmune diseases, including rheumatoid arthritis, multiple sclerosis and diabetes. Herein, we present (a) a review of the channel kinase properties of TRPM7 and its pharmacological properties, (b) discuss the role of TRPM7 in immune cells (neutrophils, macrophages, lymphocytes and mast cells) and its upstream immunoreactive substances, and (c) highlight TRPM7 as a potential therapeutic target for autoimmune diseases.
The surgical technique of the convergent procedure
Authors: Yammine Maroun , Puskas John , El Moheb Mohamad , Lattouf Omar 
Published: September 2021

AbstractThe convergent procedure is a newly developed hybrid ablation procedure that involves extensive epicardial ablation of the posterior left atrial wall followed by endocardial mapping and addition of pulmonary vein isolation. It is a team‐based approach that provides a promising option for patients with persistent and permanent atrial fibrillation. In this manuscript, we present a detailed description of the surgical component of this procedure and include potential pitfalls based on our experience in performing it.
When cultures collide: What can we learn from frictions in the implementation of design thinking?
Authors: Carlgren Lisa , BenMahmoud‐Jouini Sihem 
Published: September 2021

AbstractIncreasing interest in the use of design thinking (DT) in innovation has called into question its integration in organizational settings. We draw upon literature on management innovation and new practice implementation that highlights potential cultural conflicts between the values and assumptions underpinning the new practice and the culture of the organization that adopts it. We investigate thecultural fit between DT and the adopting firmthrough qualitative studies of 13 cases of DT implementation in large established firms complemented with data collected during eight workshops with DT practitioners and scholars. We abductively propose a cultural archetype of DT comprising eight dimensions:subjective and aesthetic ways of knowing,long‐term and nonlinear views about time,intrinsic motivation and sense of purpose,flexibility and change,relationships,empathy,and emotions at work,collaboration and inclusion,team autonomy and informality, andexternal orientation. We identify challenges and consequences associated with cultural misfits encountered in the implementation of DT:lack of legitimacy,lack of depth,disengagement,incrementalism,poor teamwork and alienation,collaboration lip service,micromanaged processes, andlack of external orientation. We thus (i) develop a characterization of DT by providing a detailed cultural archetype that we discuss relative to previous literature on DT and (ii) enrich the research on the recursive relationship between organizational culture and DT implementation, contributing to research on emotions in management and innovation culture. We also (iii) contribute to research on the challenges encountered by firms when adopting DT, extending the research on difficulties linked to cultural misfits when implementing new practices. Finally, we (iv) contribute to research on practice implementation and management innovation by highlighting the interplay between cultural fit, legitimacy, and the implementation climate.
The association between hepatocarcinogenesis and intracellular alterations due to hepatitis B virus infection
Authors: Tsuge Masataka 
Published: September 2021

AbstractChronic hepatitis B virus (HBV) infection is a worldwide health problem leading to severe liver dysfunction, including liver cirrhosis and hepatocellular carcinoma. Although current antiviral therapies for chronic HBV infection have been improved and can lead to a strong suppression of viral replication, it is difficult to completely eliminate the virus with these therapies once chronic HBV infection is established in the host. Furthermore, chronic HBV infection alters intracellular metabolism and signalling pathways, resulting in the activation of carcinogenesis in the liver. HBV produces four viral proteins: hepatitis B surface‐, hepatitis B core‐, hepatitis B x protein, and polymerase; each plays an important role in HBV replication and the intracellular signalling pathways associated with hepatocarcinogenesis. In vitro and in vivo experimental models for analyzing HBV infection and replication have been established, and gene expression analyses using microarrays or next‐generation sequencing have also been developed. Thus, it is possible to clarify the molecular mechanisms for intracellular alterations, such as endoplasmic reticulum stress, oxidative stress, and epigenetic modifications. In this review, the impact of HBV viral proteins and intracellular alterations in HBV‐associated hepatocarcinogenesis are discussed.
The role of pollination in controlling Ginkgo biloba ovule development
Authors: D’Apice Greta , Moschin Silvia , Araniti Fabrizio , Nigris Sebastiano , Di Marzo Maurizio , Muto Antonella , Banfi Camilla , Bruno Leonardo , Colombo Lucia , Baldan Barbara 
Published: September 2021

Summary

Generally, in gymnosperms, pollination and fertilization events are temporally separated and the developmental processes leading the switch from ovule integument into seed coat are still unknown. The single ovule integument of Ginkgo biloba acquires the typical characteristics of the seed coat long before the fertilization event. In this study, we investigated whether pollination triggers the transformation of the ovule integument into the seed coat.

Transcriptomics and metabolomics analyses performed on ovules just prior and after pollination lead to the identification of changes occurring in Ginkgo ovules during this specific time.

A morphological atlas describing the developmental stages of ovule development is presented. The metabolic pathways involved in the lignin biosynthesis and in the production of fatty acids are activated upon pollination, suggesting that the ovule integument starts its differentiation into a seed coat before the fertilization.

Omics analyses allowed an accurate description of the main changes that occur in Ginkgo ovules during the pollination time frame, suggesting the crucial role of the pollen arrival on the progression of ovule development.
PTEN regulates proliferation and osteogenesis of dental pulp cells and adipogenesis of human adipose‑derived stem cells
Authors: Nowwarote Nunthawan , Osathanon Thanaphum , Fournier Benjamin P.J. , Theerapanon Thanakorn , Yodsanga Somchai , Kamolratanakul Paksinee , Porntaveetus Thantrira , Shotelersuk Vorasuk 
Published: September 2021

AbstractObjectiveTo investigate the role of phosphatase and tensin homolog (PTEN) in dental pulp cells (hDPs) and adipose‐derived mesenchymal stem cells (hADSCs).Materials and MethodsGenetic variant was identified with exome sequencing. The hDPs isolated from a patient with Cowden syndrome were investigated for their proliferation, osteogenesis, adipogenesis, and gene expression compared with controls. The normal hDPs and hADSCs were treated with the PTEN inhibitor, VO‐OHpic trihydrate (VOT), to investigate the effect of PTEN inhibition.ResultsA heterozygous nonsense PTEN variant, c.289C>T (p.Gln97*), was identified in the Cowden patient's blood and intraoral lipomas. The mutated hDPs showed significantly decreased proliferation, but significantly upregulated RUNX2 and OSX expression and mineralization, indicating enhanced osteogenic ability in mutated cells. The normal hDPs treated with VOT showed the decreases in proliferation, colony formation, osteogenic marker genes, alkaline phosphatase activity, and mineral deposition, suggesting that PTEN inhibition diminishes proliferation and osteogenic potential of hDPs. Regarding adipogenesis, the VOT‐treated hADSCs showed a reduced number of cells containing lipid droplets, suggesting that PTEN inhibition might compromise adipogenic ability of hADSCs.ConclusionsPTEN regulates proliferation, enhances osteogenesis of hDPs, and induces adipogenesis of hADSCs. The gain‐of‐function PTEN variant, p.Gln97*, enhances osteogenic ability of PTEN in hDPs.
Effect of a self‐care training program using smartphones on general health, nutrition status, and sleep quality in the elderly
Authors: Vizeshfar Fatemeh , Ghelbash Zakiye 
Published: September 2021

BackgroundSelf‐care training programs can be an important means for educating the elderly in behaviours that promote health and the quality of life. Since sleep disorders, and problems related to eating patterns and general health, become more apparent with age, we aimed to investigate the effect of a self‐care training program using smartphones on general health, nutritional status, and sleep quality of the elderly.MethodsIn this randomized quality improvement trial with a pretest/post‐test design, 54 healthy and independent elderly were enrolled and randomly allocated to intervention and control groups. The interventions included 21 sessions of self‐care training that were presented virtually using smartphones.ResultsSignificant differences before and after the intervention were observed for the intervention group with respect to measures of general health, nutrition, and sleep quality.ConclusionTraining in health‐promoting self‐care behaviours, delivered by smartphone, should be considered as a major strategy for maintaining and promoting health among the elderly.
Policy innovation through noise in implementation: Best to be grey (or silver) on Friday, in Halifax
Authors: Hargreaves Heap Shaun , Talavera Oleksandr 
Published: September 2021

AbstractWhen the implementation of regulations requires judgement, there is bound to be noise in the application of the rules, but is there bias in the noise such that policy innovation, in effect, occurs in implementation? We use a recently available large postcode data set on the MOT road safety testing in the UK to answer this question. There is significant bias: the probability of failing varies systematically across postcodes, day of the week and vehicle colour. A national policy is undermined by this variability and we suggest how policy might be adjusted to reduce this unintended policy innovation.
Cariad [Love]
Authors: Sobande Francesca 
Published: September 2021

AbstractI’m still not sure what this poem means to me, let alone what it may mean to other people. However, when revisiting this poem nearly a year since writing it, I felt ready to share a few more words. I wrote this poem in the midst of experiencing loss and grief. I wrote it while spending time with family in Scotland, before returning to where I live in South Wales. Truth be told, I did not write it with the intention of contributing to scholarly work on Black geographies. Instead, the poem was penned in the wee hours of a restless summer night/morning and was part of how I was feeling and writing through grief at the time. In the months since writing this piece, I have had time and space to see things in and through the poem that I did not see before. Reflecting on which words I know in what languages, and how and why I know them. Thinking about the lives of Black people in the predominantly white nations of Scotland and Wales. Considering what it means to live in these devolved nations in Britain, where public conversations concerning Anglocentrism, colonialism, and language often occur in ways that obscure the specific experiences of Black people who do (and don’t) speak Scots and Welsh. The place from which this piece was written was a place of grief, restlessness, pain, peace, and remembrance for words, food, time, and love shared with specific people. I’m not sure how to preface a poem, nor am I sure if what I’m prefacing is even a poem at all. Perhaps that is precisely what this is all about. Grasping for certainty, locatedness, and linear narrative and history, while knowing that uncertainty, (dis)location, and divergence is often a part of Black geographies.
Smallholder Farmers’ Perception and Adaptation to Climate Change in Kurmuk District, Ethiopia
Authors: Ayansa Asaye Damera , Bedemo Amsalu , Jara Gemechu Ordofa 
Published: September 2021

Ethiopia is among the countries experiencing frequent drought and highly vulnerable to climate change associated impacts. Adaptation to climate change impacts are key element for sustainable development of economy. The objective of the study was analysis determinates of smallholder farmer’s climate change perception and adaptation options in Kurmuk district. For the study both primary and secondary data sources were employed. The primary data collected from 160 randomly selected sample households. The binary logit and multinomial logit model were employed to identify the factor that determines smallholder farmers’ climate change perception and adaptation strategies respectively. Results revealed that sex, extension service, credit access, climate information and distance from market are significantly affects smallholder farmers’ perception to climate change in kurmuk district, While, sex, education, cultivated land, access to credit services, climate information, access to market, extension service, distance from farm, off-farm income and on-farm income are found statistically significant affected adaptation options of smallholder farmers. Therefore, strengthening extension services, access credit services, disseminating climate and market information, diversification of farmer’s income are among the recommendable mechanisms to advance their perception and adaptation to climate change.
Perceptions, experiences, and attitudes of health care professionals regarding the role of librarians in fostering evidence-based health practice: a systematic review protocol
Authors: Obasola Oluwaseun Ireti , Kinengyere Alison Annet , Peter Devind , Chiweza Diston , Ross-White Amanda , Godfrey Christina 
Published: September 2021

ABSTRACT

Objective:
The objective of this systematic review is to explore perceptions, experiences, and attitudes of health care professionals in teaching hospitals, academic health science centers, and health care professional colleges regarding the role of librarians in fostering the production of evidence-based research.

Introduction:
Evidence-based health practice entails the use of the best research evidence, combined with knowledge and information gained through professional expertise as a practicing clinician, and consideration of patients’ concerns and preferences to make the best possible decision for the care provided to those patients. With their extensive skills in literature searching, librarians and other information professionals contribute to the process of evidence-based health practice by locating and retrieving the most relevant information for clinical practice. Despite the importance of librarians in evidence-based health practice, little attention has been paid to the perceptions and attitudes of health care professionals toward the involvement of librarians in fostering evidence-based research and their participation in other evidence-based health practice activities.

Inclusion criteria:
The population of interest is health care professionals working in teaching hospitals, academic health science centers, and health care professional colleges who make clinical decisions based on evidence, clinical judgments, and patient values.

Methods:
The following databases will be searched from database inception till June 2021 for published and unpublished studies: CINAHL, PsycINFO, AMED, Academic Search Premier, Scopus, LISTA, MEDLINE, POPLINE, and OpenGrey. Studies published in English will be considered for review. The selected studies will be critically assessed for methodological quality by two independent reviewers.

Systematic review registration number:
PROSPERO CRD42019136749
La comprensión de las meteduras de pata en escolares con autismo. Su relación con variables cognitivas y de teoría de la mente
Authors: García-Molina Irene , Clemente-Estevan Rosa-Ana 
Published: September 2021

El presente estudio tiene una doble finalidad. La primera es analizar dos de las variables implicadas en la comprensión de las meteduras de pata (MP) en el autismo (Cociente Intelectual; CI, y la Falsa Creencia; FC). La segunda, examinar en detalle las dificultades encontradas en la tarea de MP, dividida la población con autismo en dos grupos según su CI (Grupo 1= rango CI 100-120, Grupo 2 = rango CI 70-85). De dicha tarea de MP, se adaptaron cuatro historias (viñetas y narración) de Baron-Cohen, O’Riordan, Stone, Jones y Plaisted (1999), y se administraron a los dos grupos de niños y pre-adolescente con autismo (N = 34) de entre 7 y 12 años (M = 9.6, DE = 1.55), que las resolvieron a partir de respuestas de elección dicotómica y de explicación verbal. Los resultados demuestran la capacidad predictiva del CI total (r = 0.53; p < 0.001; R2 = 0.28) y de la FC (r = 0.51; p < 0.001; R2 = 0.26). El 40 % de la variabilidad de la tarea de MP se vio explicada por las variables predictores FC y Vocabulario. Además, se encontraron diferencias significativas entre grupos (el Grupo 1 respondió mejor que el Grupo 2) tanto en respuestas de elección forzada personaje (ii) e ignorancia (vii) y la suma total como en su explicación verbal. Estos resultados se discuten más detalladamente debido a su posible repercusión en la vida diaria de las personas con autismo.