bluuebunny/crossref_metadata_2025_split huggingface dataset:
Symptom-specific differential motor network modulation by deep brain stimulation in Parkinson’s disease
Authors: Gibson William S. , Rusheen Aaron E. , Oh Yoonbae , In Myung-Ho , Gorny Krzysztof R. , Felmlee Joel P. , Klassen Bryan T. , Jung Sung Jun , Min Hoon-Ki , Lee Kendall H. , Jo Hang Joon 
Published: May 2021

OBJECTIVE
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established neurosurgical treatment for the motor symptoms of Parkinson’s disease (PD). While often highly effective, DBS does not always yield optimal therapeutic outcomes, and stimulation-induced adverse effects, including paresthesia, muscle contractions, and nausea/lightheadedness, commonly occur and can limit the efficacy of stimulation. Currently, objective metrics do not exist for monitoring neural changes associated with stimulation-induced therapeutic and adverse effects.

METHODS
In the present study, the authors combined intraoperative functional MRI (fMRI) with STN DBS in 20 patients with PD to test the hypothesis that stimulation-induced blood oxygen level–dependent signals contained predictive information concerning the therapeutic and adverse effects of stimulation.

RESULTS
As expected, DBS resulted in blood oxygen level–dependent activation in myriad motor regions, including the primary motor cortex, caudate, putamen, thalamus, midbrain, and cerebellum. Across the patients, DBS-induced improvements in contralateral Unified Parkinson’s Disease Rating Scale tremor subscores correlated with activation of thalamic, brainstem, and cerebellar regions. In addition, improvements in rigidity and bradykinesia subscores correlated with activation of the primary motor cortex. Finally, activation of specific sensorimotor-related subregions correlated with the presence of DBS-induced adverse effects, including paresthesia and nausea (cerebellar cortex, sensorimotor cortex) and unwanted muscle contractions (caudate and putamen).

CONCLUSIONS
These results suggest that DBS-induced activation patterns revealed by fMRI contain predictive information with respect to the therapeutic and adverse effects of DBS. The use of fMRI in combination with DBS therefore may hold translational potential to guide and improve clinical stimulator optimization in patients.
Status epilepticus after intracranial neurosurgery: incidence and risk stratification by perioperative clinical features
Authors: Jin Michael C. , Parker Jonathon J. , Zhang Michael , Medress Zack A. , Halpern Casey H. , Li Gordon , Ratliff John K. , Grant Gerald A. , Fisher Robert S. , Skirboll Stephen 
Published: May 2021

OBJECTIVE
Status epilepticus (SE) is associated with significant mortality, cost, and risk of future seizures. In one of the first studies of SE after neurosurgery, the authors assess the incidence, risk factors, and outcome of postneurosurgical SE (PNSE).

METHODS
Neurosurgical admissions from the MarketScan Claims and Encounters database (2007 through 2015) were assessed in a longitudinal cross-sectional sample of privately insured patients who underwent qualifying cranial procedures in the US and were older than 18 years of age. The incidence of early (in-hospital) and late (postdischarge readmission) SE and associated mortality was assessed. Procedural, pathological, demographic, and anatomical covariates parameterized multivariable logistic regression and Cox models. Multivariable logistic regression and Cox proportional hazards models were used to study the incidence of early and late PNSE. A risk-stratification simulation was performed, combining individual predictors into singular risk estimates.

RESULTS
A total of 197,218 admissions (218,217 procedures) were identified. Early PNSE occurred during 637 (0.32%) of 197,218 admissions for cranial neurosurgical procedures. A total of 1045 (0.56%) cases of late PNSE were identified after 187,771 procedure admissions with nonhospice postdischarge follow-up. After correction for comorbidities, craniotomy for trauma, hematoma, or elevated intracranial pressure was associated with increased risk of early PNSE (adjusted OR [aOR] 1.538, 95% CI 1.183–1.999). Craniotomy for meningioma resection was associated with an increased risk of early PNSE compared with resection of metastases and parenchymal primary brain tumors (aOR 2.701, 95% CI 1.388–5.255). Craniotomies for infection or abscess (aHR 1.447, 95% CI 1.016–2.061) and CSF diversion (aHR 1.307, 95% CI 1.076–1.587) were associated with highest risk of late PNSE. Use of continuous electroencephalography in patients with early (p < 0.005) and late (p < 0.001) PNSE rose significantly over the study time period. The simulation regression model predicted that patients at high risk for early PNSE experienced a 1.10% event rate compared with those at low risk (0.07%). Similarly, patients predicted to be at highest risk for late PNSE were significantly more likely to eventually develop late PNSE than those at lowest risk (HR 54.16, 95% CI 24.99–104.80).

CONCLUSIONS
Occurrence of early and late PNSE was associated with discrete neurosurgical pathologies and increased mortality. These data provide a framework for prospective validation of clinical and perioperative risk factors and indicate patients for heightened diagnostic suspicion of PNSE.
Cost-effectiveness analysis in patients with an unruptured cerebral aneurysm treated with observation or surgery
Authors: Dandurand Charlotte , Zhou Lily , Prakash Swetha , Redekop Gary , Gooderham Peter , Haw Charles S. 
Published: May 2021

OBJECTIVE
The main goal of preventive treatment of unruptured intracranial aneurysms (UIAs) is to avoid the morbidity and mortality associated with aneurysmal subarachnoid hemorrhage. A comparison between the conservative approach and the surgical approach combining endovascular treatment and microsurgical clipping is currently lacking. This study aimed to conduct an updated evaluation of cost-effectiveness comparing the two approaches in patients with UIA.

METHODS
A decision tree with a Markov model was developed. Quality-adjusted life-years (QALYs) associated with living with UIA before and after treatment were prospectively collected from a cohort of patients with UIA at a tertiary center. Other inputs were obtained from published literature. Using Monte Carlo simulation for patients aged 55, 65, and 75 years, the authors modeled the conservative management in comparison with preventive treatment. Different proportions of endovascular and microsurgical treatment were modeled to reflect existing practice variations between treatment centers. Outcomes were assessed in terms of QALYs. Sensitivity analyses to assess the model’s robustness and completed threshold analyses to examine the influence of input parameters were performed.

RESULTS
Preventive treatment of UIAs consistently led to higher utility. Models using a higher proportion of endovascular therapy were more cost-effective. Models with older cohorts were less cost-effective than those with younger cohorts. Treatment was cost-effective (willingness to pay < 100,000 USD/QALY) if the annual rupture risk exceeded a threshold between 0.8% and 1.9% in various models based on the proportion of endovascular treatment and cohort age. A higher proportion of endovascular treatments and younger age lowered this threshold, making the treatment of aneurysms with a lower risk of rupture more cost-effective.

CONCLUSIONS
Preventive treatment of aneurysms led to higher utility compared with conservative management. Models with a higher proportion of endovascular treatment and younger patient age were most cost-effective.
Effects of Temperature on Population Growth and Resting Egg Production of Freshwater Rotifer (Brachionus calyciflorus)Effects of Temperature on Population Growth and Resting Egg Production of Freshwater Rotifer (Brachionus calyciflorus)
Authors: Nhinh Doan Thi , Hong Pham Thi Lam , Hoai Truong Dinh , Van Kim Van 
Published: May 2021

Resting egg production of rotifers provides critical advantages in larviculture of most fish species due to the reduction in the costs of labour and algae production. The study was conducted to investigate the effects of temperature on population growth and resting egg production of a freshwater rotifer, Brachionus calyciflorus, collected in Northern Vietnam. The rotifer was pre-cultured at 27ºC before being transferred to the cultures at 15 and 35ºC while the control was maintained at 27ºC. One-liter beakers filled with 500mL culture medium were used with three replicates for each temperature group. Stock rotifers were inoculated at an initial density of 200 ind ml-1 and fed with concentrated fresh algae. The results indicated that population growth rate (r) of rotifers cultured at 27 and 35ºC were significantly higher than that of rotifers at 15ºC while the highest density was attained from the treatment of 27ºC, at 608.3 ind mL-1, compared to 468.3 and 360.5 ind mL-1 at 35 and 15ºC, respectively. Transferring the cultures from 27 to 35ºC significantly increased the rate of resting egg carrying females with the maximum rate of 31.5% compared to 21.2 and 13.5% of the rotifers at 27 and 15ºC, respectively. The resting egg densities of the cultures at 35ºC were also significantly higher than those at 15 and 27ºC. The resting egg carrying females appeared and increased their rates in concurrence with increases in the population density. The present results are important information for resting egg induction and production of rotifer in larviculture.
Modified Atmosphere Packaging Reduces Pericarp Browning and Maintains the Quality of ‘Huong Chi’ Longan Fruit (Dimocarpus Longan) Pretreated with Citric Acid
Authors: Thuy Nguyen Thi Bich , Hanh Nguyen Thi 
Published: May 2021

Longan ‘Huong Chi’ (Dimocarpus longan Lour.) is one of the most favorite and widely exported fruits in Vietnam, but the trading of longan faces considerable challenges due to rapid pericarp browning and decay. Our study aimed to determine the effects of modified atmospheres generated by low-density polyethylene (LDPE), polypropylene bag (PP), and LifeSpan L201 films on the quality and pericarp browning of ‘Huong Chi’ longan fruit pre-treated with 3.0 % citric acid and stored at 5oC. The results showed that LifeSpan L201 and LDPE packaging created an equilibrium atmosphere of 10.66 ± 0.78% O2, 4.44 ± 0.64% CO2, and 15.04 ± 0.89% O2, 2.96 ± 0.61% CO2, respectively. The modified atmospheres generated by LifeSpan L201 and LDPE delayed pericarp browning, maintained the total soluble solids (TSS) and vitamin C content, and reduced decay in longan fruit. Meanwhile, the PP packaging resulted in an improperly modified atmosphere which led to severe decay and browning in cold storage conditions.
A Modal Semantics of Negation in Logic Programming
Authors: Balbiani Philippe 
Published: May 2021

The beauty of modal logics and their interest lie in their ability to represent such different intensional concepts as knowledge, time, obligation, provability in arithmetic, … according to the properties satisfied by the accessibility relations of their Kripke models (transitivity, reflexivity, symmetry, well-foundedness, …). The purpose of this paper is to study the ability of modal logics to represent the concepts of provability and unprovability in logic programming. The use of modal logic to study the semantics of logic programming with negation is defended with the help of a modal completion formula. This formula is a modal translation of Clack’s formula. It gives soundness and completeness proofs for the negation as failure rule. It offers a formal characterization of unprovability in logic programs. It characterizes as well its stratified semantics.
Recognizing Visibility Graphs of Triangulated Irregular Networks
Authors: Boomari Hossein , Ostovari Mojtaba , Zarei Alireza 
Published: May 2021

A Triangulated Irregular Network (TIN) is a data structure that is usually used for representing and storing monotone geographic surfaces, approximately. In this representation, the surface is approximated by a set of triangular faces whose projection on the XY-plane is a triangulation. The visibility graph of a TIN is a graph whose vertices correspond to the vertices of the TIN and there is an edge between two vertices if their corresponding vertices on TIN see each other, i.e. the segment that connects these vertices completely lies above the TIN. Computing the visibility graph of a TIN and its properties have been considered thoroughly in the literature. In this paper, we consider this problem in reverse: Given a graph G, is there a TIN with the same visibility graph as G? We show that this problem is ∃ℝ- Complete.
Leadership Responsibilities in Information Security Awareness Development
Authors: Kárász Balázs , Kollár Csaba 
Published: May 2021

This paper aims to introduce the main aspects arising in the organisational context related to leadership roles when information security awareness is being engineered and developed according to purposes set within. Achieving these development purposes is connected to the commanding function of leadership, while being influenced by key human risk factors such as: leadership commitment and example setting, leadership quality, the state of being motivated and above all, the ability of responsible decision- making on a professional basis. In order to improve the effectiveness of putting the implementation into practice, a methodological toolset needs to be elaborated for the disposal of the leader, thanks to which, besides taking on a transactional leadership style and a cyclic program management, the continuous monitoring and tailoring to the organisation of the development purposes all become facilitated.
Analyzing indicators of the results of applying forecasting methods for production plans (A case study at the Diyala State Company for Electrical Industries)
Authors: Ismael Emad Khaleel 
Published: May 2021

Economic organizations operate in a dynamic environment, which necessitates the use of quantitative techniques to make their decisions. Here, the role of forecasting production plans emerges. So, this study aims to the analysis of the results of applying forecasting methods to production plans for the past years, in the Diyala State Company for Electrical Industries.
The Diyala State Company for Electrical Industries was chosen as a field of research for its role in providing distinguished products as well as the development and growth of its products and quality, and because it produces many products, and the study period was limited to ten years, from 2010 to 2019. This study used the descriptive approach in the theoretical side of the study, on the practical side, the current study used the statistical application (SPSS), and some other statistical means to process and analyze what was collected from data related to the company, the research sample, from its official website.
The research concluded that flooding the Iraqi market with alternative imported products for the products of the Electrical Industries Company led to the cessation of production of some of the company's products, As a result, its resources were not invested efficiently and production costs were high. The current study suggested that the Ministry of Electricity buy the company's products, as these products have a good quality compared with the foreign ones.
Comparison of Some Methods for Estimating Parameters of General Linear Model in Presence of Heteroscedastic Problem and High Leverage Points
Authors: Saheb Qasim Mohammed , Hussein Saja Mohammad 
Published: May 2021

Linear regression is one of the most important statistical tools through which it is possible to know the relationship between the response variable and one variable (or more) of the independent variable(s), which is often used in various fields of science. Heteroscedastic is one of the linear regression problems, the effect of which leads to inaccurate conclusions. The problem of heteroscedastic may be accompanied by the presence of extreme outliers in the independent variables (High leverage points) (HLPs), the presence of (HLPs) in the data set result unrealistic estimates and misleading inferences. In this paper, we review some of the robust weighted estimation methods that accommodate both Robust and classical methods in the detection of extreme outliers (High leverage points) (HLPs) and the determination of weights. The methods include both Diagnostic Robust Generalized Potential Based on Minimum Volume Ellipsoid (DRGP (MVE)), Diagnostic Robust Generalized Potential Based on Minimum Covariance Determinant (DRGP (MCD)), and Diagnostic Robust Generalized Potential Based on Index Set Equality (DRGP (ISE)). The comparison was made according to the standard error criterion of the estimated parameters SE ( ) and SE ( ) of general linear regression model, for sample sizes (n=60, n=100, n=160), with different degree (severity) of heterogeneity, and contamination percentage (HLPs) are (τ =10%, τ=30%). it was found through comparison that weighted least squares estimation based on the weights of the DRGP (ISE) method are considered the best in estimating the parameters of the multiple linear regression model because they have the lowest standard error values of the estimators ( ) and ( ) as compared to other methods.
Paper type: A case study
The The Effect of Continuous Suspension Constraint on the Free Vibration and Buckling of a Beam
Authors: Németh Róbert K. , Alzubaidi Bilal M. A. 
Published: May 2021

In this paper, the free vibration and the buckling of a continuously suspended simply-supported beam are analyzed. A semi-analytical approach is used to calculate the natural circular frequencies and the critical forces of the beam. The length of the suspension is used as a parameter, and the natural circular frequencies and the critical forces are presented in a frequency map or a buckling map. The maps are analyzed in view of the trivial solutions, and the frequency map is compared to the map of discrete cable-stayed beams. Finally, for the validation of the results a numerical, finite element analysis is performed.
Tratamento endodôntico conservador em lesão periapical extensa asséptica: Relato de caso
Authors: Travassos Rosana Maria Coelho , Negreiros Jhony Herick Cavalcanti Nunes , Teixeira Joás de Araújo , Lyra Maria Carlla Aroucha , Barbosa Lívia Mirelle , Lima Netto Osman Jucá Rêgo 
Published: May 2021

Embora o fator etiológico mais frequente de injúria pulpar seja a presença de microrganismos que estabelecem um quadro infeccioso, uma polpa injuriada (assepticamente) por traumatismo torna-se mais sensível às bactérias infectantes que uma polpa dental saudável. O caso clínico apresentado neste trabalho descreve o sucesso de um tratamento endodôntico conservador de um elemento dentário necrosado por trauma e apresentando extensa lesão periapical crônica. Após a realização do acesso, limpeza do conduto e implementação do curativo de demora à base de pasta de hidróxido de cálcio, ocorreu a reagudização expressiva da lesão. Porém, o callen associado ao PMCC apresentou eficácia para o tratamento da lesão quando adotado como segunda escolha para a medicação intracanal. Após a obturação do canal radicular pela técnica Híbrida de Tagger, foi realizada a proservação do caso durante 1 ano, constatando-se radiograficamente a remissão da lesão. O sucesso do tratamento deste caso esteve diretamente relacionado ao correto diagnóstico que permitiu o estabelecimento da melhor conduta. Abordagens mais conservadoras devem ser a primeira escolha do profissional mesmo diante de casos complexos, como o apresentado.
Symptom experience of adverse drug reaction among male and female patients with newly diagnosed pulmonary tuberculosis in Thailand
Authors: Thontham Apichaya , Polsook Rapin 
Published: May 2021

Background: Patients with newly diagnosed pulmonary tuberculosis often suffer from adverse drug reaction symptoms, which leads to the automatic discontinuation of anti-tuberculosis drugs. Thus, understanding symptom experience of adverse drug reactions is necessary. Objective: This study aimed to examine differences in symptoms experienced in four dimensions: presence, frequency, severity, and distress of adverse drug reactions, between male and female patients. Methods: This was a quantitative survey with a cross-sectional design, with data collected between January and April 2020. A total of 394 patients with newly diagnosed pulmonary tuberculosis was selected through a purposive sampling technique. The symptom experiences of adverse drug reactions were measured using a validated instrument. Data were analyzed using mean, standard deviation, and independent t-test. Results: The most commonly reported symptom was itchiness (24.1% in males and 34.9% in females). Vomiting occurred as the most frequent symptom among males (x̅ ± SD = 2.73 ± .88), and fatigue was found to be the most severe and distressing symptom across male patients (x̅ ± SD = 2.50 ± 1.61 and 2.06 ± 1.30, respectively). In contrast, yellowing of the eyes and skin was most frequent and severe among females (x̅ ± SD = 3.17 ± .75 and 3.83 ± 1.47, respectively). In addition, flu-like symptoms were evaluated as the most distressing symptom for female patients (x̅ ± SD = 2.80 ± 1.09). The symptom burdens of the females ranged significantly and reached higher than those of the male patients at a p-value of .05 (t = 3.33). Conclusion: Females taking anti-tuberculosis drugs should be carefully monitored to deal with adverse drug reaction symptoms. This finding would help to decrease the severity of disease and improve their quality of life. Funding: This study received funding from the Ratchadaphiseksomphot Endowment Fund, Chulalongkorn University, Bangkok, Thailand (GCUGR1125633058M).
Emergence of Invasive Serotype Ib Sequence Type 10 Group B Streptococcus Disease in Chinese Infants Is Driven by a Tetracycline-Sensitive Clone
Authors: Zhang Li , Kang Wen-Juan , Zhu Lei , Xu Li-Jun , Guo Chao , Zhang Xin-Hua , Liu Qing-Hua , Ma Lan 
Published: May 2021

BackgroundGroup B streptococcus (GBS) is a leading cause of serious infections in infants. The extensive use of tetracycline has led to the selection of specific resistant and infectious GBS clones. The sequence type (ST) 10 GBS strain, causing invasive infections in infants, is becoming prevalent in China. We aimed to understand the clinical and microbiological characteristics of this GBS strain.MethodsWe conducted a retrospective study on infants with invasive GBS disease from the largest women’s and children’s medical center in Shanxi and collected data between January 2017 and October 2020. GBS isolates were analyzed by capsule serotyping, genotyping, antibiotic resistance, and surface protein genes.ResultsAll ST10 isolates belonged to serotype Ib; type Ib/ST10 strains were responsible for 66.7% (14/21, P &lt; 0.05) of infant invasive GBS infections during the period and all resulted in late-onset (LOD) and late LOD disease (14/14). Infants with type Ib/ST10 GBS disease had significantly higher rates of meningitis (9/14, 64.3%, p &lt; 0.05) and clinical complications (5/14, 35.7%, p &lt; 0.05). The Ib/ST10 GBS isolates had limited genetic diversity, clustered in the CC10/bca/PI-1 + PI-2a genetic lineage, showed resistance to erythromycin, lincomycin, and fluoroquinolones and sensitivity to tetracycline, and possessed genes ermT, ermB, and amino acid changes in gyrA and parC.ConclusionsThe probable clonal expansion can result in severe infections in infants and ongoing emergence of multi-drug resistant isolates. Continued monitoring for type Ib/ST10 GBS infections is warranted.