bluuebunny/crossref_metadata_2025_split huggingface dataset:
Withdrawal Notice: The Correlation Between ERRα Expression Level and Pathological Grade, Overall Survival, and Cancer Types: A Study on a Cohort of 150 Patients with Breast Cancer
Authors: Sun Ning , Li Chenchen , Teng Yue , Deng Yuxia , Shi Lin 
Published: July 2021

The article has been withdrawn by agreement between the editors and publisher of Recent Patents on Anti-Cancer Drug Discovery. The authors are not responding to the editor's requests to provide the language-edited version.

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Artificial Intelligence and Cancer Drug Development
Authors: Yang Mary Q. , Wang Shanzhi , Yang Fan , Darsey Jerry A. , Ghosh Anindya , Li Hong-Yu 
Published: July 2021

Background:
The development of cancer drugs is among the most focused “bench to
bedside activities” to improve human health. Because of the amount of data publicly available to
cancer research, drug development for cancers has significantly benefited from big data and Artificial
Intelligence (AI). In the meantime, challenges, like curating the data of low quality, remain to
be resolved.

Objective:
This review focused on the recent advancements in and challenges of AI in developing
cancer drugs.

Method:
We discussed target validation, drug repositioning, de novo design, and compounds' synthetic
strategies.

Results and Conclusion:
AI can be applied to all stages during drug development, and some excellent
reviews detailing the applications of AI in specific stages are available.
An Update of Lysine Specific Demethylase 1 Inhibitor: A Patent Review
(2016-2020)
Authors: Wang Bo , Liu Hong-Min , Zheng Yi-Chao , Liu Yue-Jiao , Gao Ya 
Published: July 2021

Background:
As a FAD (Flavin Adenine Dinucleotide) - dependent histone demethylase
discovered in 2004, LSD1 (lysine-specific demethylase 1) was reported to be overexpressed in
diverse tumors, regulating target genes transcription associated with cancer development. Hence,
LSD1 targeted inhibitors may represent a new insight in anticancer drug discovery. For these reasons,
researchers in both the pharmaceutical industry and academia have been actively pursuing LSD1
inhibitors in the quest for new anti-cancer drugs.

Objectives:
This review summaries patents about LSD1 inhibitors in recent 5 years in the hope of
providing a reference for LSD1 researchers to develop new modulators of LSD1 with higher potency
and fewer adverse effects.

Methods:
This review collects LSD1 inhibitors disclosed in patents since 2016. The primary ways
of patent searching are Espacenet®, Google Patents, and CNKI.

Results:
This review covers dozens of patents related to LSD1 inhibitors in recent five years. The
compound structures are mainly divided into TCP (Tranylcypromine) derivatives, imidazole derivatives,
pyrimidine derivatives, and other natural products and peptides. Meanwhile, the compounds
that have entered the clinical phase are also described.

Conclusion:
Most of the compounds in these patents have been subjected to activity analysis with
LSD1 and multi-cell lines, showing good antitumor activity in vitro and in vivo. These patents exhibited
the structural diversity of LSD1 inhibitors and the potential of natural products as novel LSD1
inhibitors.
COVID-19 Vaccines: Fabrication Techniques and Current Status
Authors: Kaur Lakhvir , Mahajan Ayushi , Singh Gurjeet , Dhawan Ravi Kumar , Singh Lovepreet , Kaur Anureet 
Published: July 2021

:
The year 2020 was the most challenging period due to the havoc caused by the outbreak
of novel coronavirus SARS-CoV-2. Scientists and researchers all around the world have endeavored
every possible approach to find solutions in context to therapeutics and vaccines to control the
spread of this life-threatening virus. The acceleration instigated by the outbreak of SARS-CoV-2
and its mutated strains has leveraged the use of numerous platform technologies for the development
of vaccines against this unfathomable disease. Vaccines could play an important role in mitigating
the effects of COVID-19 and reducing the ongoing health crisis. Various innovative platforms
like proteins, nucleic acids, viruses, and viral vectors have been exploited to fabricate
vaccines depicting almost 90% of efficacy like BNT162b2, AZD1222, Ad5-nCoV, etc. Some of these
vaccines are multipotent and have shown potent activity against newly emerged malicious
strains of SARS-CoV-2 like B.1.351 and B.1.1.7. In this review article, we have gathered key findings
from various sources of recently popularized vaccine candidates, which will provide an
overview of potential vaccine candidates against this virus and will help the researchers to investigate
possible ways to annihilate this menace and design new moieties.
Toward a Behavior Theory–Informed and User-Centered Mobile App for Parents to Prevent Infant Falls: Development and Usability Study
Authors: Cooray Nipuna , Sun Si Louise , Ho Catherine , Adams Susan , Keay Lisa , Nassar Natasha , Brown Julie 
Published: July 2021

Background
Falls account for approximately 50% of infant injury hospitalizations, and caretaker behavior is central to preventing infant falls. Behavior theory–informed interventions for injury prevention have been suggested, but to date, few have been reported. The potential of using smartphones for injury prevention intervention delivery is also underexploited.

Objective
This study aims to develop a behavior theory– and evidence-based as well as user-centered digital intervention as a mobile app for parents to prevent infant falls following agile development practices.

Methods
Infant falls while feeding was selected as the fall mechanism to demonstrate the approach being taken to develop this intervention. In phase 1, the Behaviour Change Wheel was used as a theoretical framework supported by a literature review to define intervention components that were then implemented as a mobile app. In phase 2, after the person-based approach, user testing through think-aloud interviews and comprehension assessments were used to refine the content and implementation of the intervention.

Results
The target behaviors identified in phase 1 were adequate rest for the newborn’s mother and safe feeding practices defined as prepare, position, and place. From behavioral determinants and the Behaviour Change Wheel, the behavior change functions selected to achieve these target behaviors were psychological capability, social opportunity, and reflective motivation. The selected behavior change techniques aligned with these functions were providing information on health consequences, using a credible source, instruction on performing each behavior, and social support. The defined intervention was implemented in a draft Android app. In phase 2, 4 rounds of user testing were required to achieve the predefined target comprehension level. The results from the think-aloud interviews were used to refine the intervention content and app features. Overall, the results from phase 2 revealed that users found the information provided to be helpful. Features such as self-tracking and inclusion of the social and environmental aspects of falls prevention were liked by the participants. Important feedback for the successful implementation of the digital intervention was also obtained from the user testing.

Conclusions
To our knowledge, this is the first study to apply the Behaviour Change Wheel to develop a digital intervention for child injury prevention. This study provides a detailed example of evidence-based development of a behavior theory–informed mobile intervention for injury prevention refined using the person-based approach.
Shift in Social Media App Usage During COVID-19 Lockdown and Clinical Anxiety Symptoms: Machine Learning–Based Ecological Momentary Assessment Study
Authors: Ryu Jihan , Sükei Emese , Norbury Agnes , H Liu Shelley , Campaña-Montes Juan José , Baca-Garcia Enrique , Artés Antonio , Perez-Rodriguez M Mercedes 
Published: July 2021

Background
Anxiety symptoms during public health crises are associated with adverse psychiatric outcomes and impaired health decision-making. The interaction between real-time social media use patterns and clinical anxiety during infectious disease outbreaks is underexplored.

Objective
We aimed to evaluate the usage pattern of 2 types of social media apps (communication and social networking) among patients in outpatient psychiatric treatment during the COVID-19 surge and lockdown in Madrid, Spain and their short-term anxiety symptoms (7-item General Anxiety Disorder scale) at clinical follow-up.

Methods
The individual-level shifts in median social media usage behavior from February 1 through May 3, 2020 were summarized using repeated measures analysis of variance that accounted for the fixed effects of the lockdown (prelockdown versus postlockdown), group (clinical anxiety group versus nonclinical anxiety group), the interaction of lockdown and group, and random effects of users. A machine learning–based approach that combined a hidden Markov model and logistic regression was applied to predict clinical anxiety (n=44) and nonclinical anxiety (n=51), based on longitudinal time-series data that comprised communication and social networking app usage (in seconds) as well as anxiety-associated clinical survey variables, including the presence of an essential worker in the household, worries about life instability, changes in social interaction frequency during the lockdown, cohabitation status, and health status.

Results
Individual-level analysis of daily social media usage showed that the increase in communication app usage from prelockdown to lockdown period was significantly smaller in the clinical anxiety group than that in the nonclinical anxiety group (F1,72=3.84, P=.05). The machine learning model achieved a mean accuracy of 62.30% (SD 16%) and area under the receiver operating curve 0.70 (SD 0.19) in 10-fold cross-validation in identifying the clinical anxiety group.

Conclusions
Patients who reported severe anxiety symptoms were less active in communication apps after the mandated lockdown and more engaged in social networking apps in the overall period, which suggested that there was a different pattern of digital social behavior for adapting to the crisis. Predictive modeling using digital biomarkers—passive-sensing of shifts in category-based social media app usage during the lockdown—can identify individuals at risk for psychiatric sequelae.
Rancang Bangun Sistem Kendali Dan Monitoring Peralatan Listrik Dalam Skala Rumah Tangga Berbasis Web
Authors: Erdin Ujang 
Published: July 2021

Seiring dengan perkembangan teknologi dan ilmu pengetahuan di bidang elektronika serta sistem kendali, banyak manusia yang memanfaatkan perkembangan ini untuk membuat kehidupan lebih mudah serta menyelesaikan masalah–masalah yang terjadi. Di era modern ini penggunaan peralatan listrik sangatlah penting karena manusia tidak terlepas dari penggunaan peralatan listrik dalam skala rumah tangga. Banyak masyarakat yang sangat menginginkan adanya sistem kendali otomatis tentang penggunaan peralatan listrik yang digunakan untuk kebutuhan rumah tangga sehari-hari. Sistem yang telah dibuat terhubung pada NodeMCU ESP8266, Relay dan terprogram dengan Arduino IDE agar lampu, kipas, dan charger handphone dapat dinyalakan melalui web browser. Selain itu penggunaan sensor LDR yang berfungsi untuk monitoring lampu. Alat bekerja sesuai dengan fungsinya, yaitu sebagai pengontrol peralatan listrik seperti lampu, kipas dan charger handphone dengan smart phone android sebagai interface melalui web server dan monitoring keadaan lampu dengan sensor LDR. Waktu yang dibutuhkan untuk menyalakan lampu dalam 5 kali percobaan rata-rata 1,6 detik, sedangkan waktu yang dibutuhkan untuk mematikan lampu dalam 5 kali percobaan rata rata 1,6 detik. Dari 5 kali percobaan, rata-rata waktu yang dibutuhkan untuk menyalakan kipas adalah 1,8 dan untuk mematikan kipas rata-rata 2 detik. Waktu yang dibutuhkan untuk menyalakan charger handphone dalam 5 kali percobaan rata-rata 1,6 dan mematikan charger handphone rata-rata 1,5. Dari keseluruhan pengujian, didapatkan waktu rata rata untuk menyalakan seluruh peralatan listrik adalah 1,63 detik dan untuk mematikan seluruh peralatan listrik adalah 1,7 detik.
TCF7L2 Genetic Variants Do Not Influence Insulin Sensitivity or Secretion Indices in Autoantibody-Positive Individuals at Risk for Type 1 Diabetes
Authors: Redondo Maria J. , Warnock Megan V. , Libman Ingrid M. , Bocchino Laura E. , Cuthbertson David , Geyer Susan , Pugliese Alberto , Steck Andrea K. , Evans-Molina Carmella , Becker Dorothy , Sosenko Jay M. , Bacha Fida ,   the Type 1 Diabetes TrialNet Study Group
Published: July 2021

OBJECTIVE
We aimed to test whether type 2 diabetes (T2D)–associated TCF7L2 genetic variants affect insulin sensitivity or secretion in autoantibody-positive relatives at risk for type 1 diabetes (T1D).

RESEARCH DESIGN AND METHODS
We studied autoantibody-positive TrialNet Pathway to Prevention study participants (N = 1,061) (mean age 16.3 years) with TCF7L2 single nucleotide polymorphism (SNP) information and baseline oral glucose tolerance test (OGTT) to calculate indices of insulin sensitivity and secretion. With Bonferroni correction for multiple comparisons, P values &lt; 0.0086 were considered statistically significant.

RESULTS
None, one, and two T2D-linked TCF7L2 alleles were present in 48.1%, 43.9%, and 8.0% of the participants, respectively. Insulin sensitivity (as reflected by 1/fasting insulin [1/IF]) decreased with increasing BMI z score and was lower in Hispanics. Insulin secretion (as measured by 30-min C-peptide index) positively correlated with age and BMI z score. Oral disposition index was negatively correlated with age, BMI z score, and Hispanic ethnicity. None of the indices were associated with TCF7L2 SNPs. In multivariable analysis models with age, BMI z score, ethnicity, sex, and TCF7L2 alleles as independent variables, C-peptide index increased with age, while BMI z score was associated with higher insulin secretion (C-peptide index), lower insulin sensitivity (1/IF), and lower disposition index; there was no significant effect of TCF7L2 SNPs on any of these indices. When restricting the analyses to participants with a normal OGTT (n = 743; 70%), the results were similar.

CONCLUSIONS
In nondiabetic autoantibody-positive individuals, TCF7L2 SNPs were not related to insulin sensitivity or secretion indices after accounting for BMI z score, age, sex, and ethnicity.
Pre-service primary school teachers’ metacognitive awareness and beliefs about mathematical problem solving
Authors: Yorulmaz Alper , Uysal Hümeyra , Çokçaliskan Halil 
Published: July 2021

Metacognitive awareness is a variable that is thought to affect beliefs in problem solving. When the literature is examined, it is seen that the studies mostly focus on metacognitive awareness and problem solving skills. Therefore, the aim is to determine pre-service primary school teachers’ metacognitive awareness and beliefs in mathematical problem solving. In this study, it is thought that it will contribute to the researches that will be carried out regarding the investigation of the relationship between metacognitive awareness and beliefs about problem solving and its implementation with pre-service primary school teachers. The study, designed as the correlational survey model, included a total of 284 pre-service primary school teachers attending a university in the Aegean Region of Turkey. The data were collected with the “Metacognitive Awareness Inventory” and the “Scale of Beliefs about Mathematical Problem Solving”. In the analysis, descriptive statistics, difference test, correlation and regression analyses were used. As a result, the pre-service primary school teachers’ metacognitive awareness was found to be high and their beliefs about mathematical problem solving were found to be medium. While metacognitive awareness was found to be not varying significantly by gender, beliefs about mathematical problem solving were found to be varying significantly by gender in favor of the male pre-service teachers. Moreover, a medium and significant correlation was found between metacognitive awareness and beliefs about mathematical problem solving. It was also found that metacognitive awareness explained 13% of the variance in the dependent variable of beliefs about mathematical problem solving.
Taxonomy as a Genre and Cycle-Forming Pattern of “Fandorin corpus” by B. Akunin
Authors: Borunov A. B. , Afanasyeva O. V. 
Published: July 2021

The issue of classification as the leading principle of organizing the set of texts by B. Akunin about Erast Fandorin are considered in the article. Particular attention is paid to the manifestation of this principle at the level of genre organization of texts and at the level of semantic and character components of works. The relevance of the study is due to the identification of the semantic constant of the metacycle about Erast Fandorin. It has been proved that the principle of taxonomy in the Fandorin corpus has two variants of manifestation — at the level of metacycle organization and at the level of semantics of the key motive of a classic detective — explaining the method used by the detective. The results of a comparative analysis of the image of Fandorin and his literary predecessors: detectives, derived in the texts of the authors of a classic detective story, are presented, and it is proved that Fandorin is the only one who explains in detail his method of investigation based on psychological classification. The authors dwell on the fact that the explanation of the method of investigation is an element of an intertextual game with the reader and at the same time, the opposition of the Russian detective to his English and American literary predecessors. At the same time, the principle of taxonomy is played up in the intertextual dialogue within the Fandorin corpus — other characters in this metacycle also resort to typing.
Magazine “Okhotnichy Vestnik”: History of its Origin and Functioning in Specialized Printing Market
Authors: Lyapina A. V. 
Published: July 2021

The history of one of the most popular Moscow magazines of nature and hunting “Okhotnichy Vestnik” (1901—1918), which for eighteen years has been associated with the trading company of the same name, is considered. The archival materials from the funds of the Russian State Historical Archive, the Central State Archive of Moscow, related to the publication and trading partnership “Okhotnichy Vestnik” are analyzed. On the basis of the historical-typological method, the program, content features of the magazin, ways of interacting with readers and competitors are studied, the reasons for its popularity during the period of historical catastrophes are considered. The novelty of the research is determined both by the empirical material itself — archival files not previously introduced into scientific circulation, and by the subject — the history of the emergence and functioning of the magazine “Okhotnichy Vestnik”. It is concluded that in the conditions of socio-political unrest and fierce competition for the reader, during the crisis of hunting journalism, “Okhotnichy Vestnik” retained the status of a fairly authoritative and influential publication thanks to the flexible policy of editors-publishers and effective methods of activity of the trade and industrial partnership “Okhotnichy Vestnik”. The history of the “Okhotnichy Vestnik” makes it possible to present a more complete picture of the formation of a new type of specialized printing.
Publicistic Reflection Of Russian Entrepreneurship in Second Half of 19th — early 20th Centuries in Context of History of Russian Journalism
Authors: Chernov A. V. , Vsevolodov A. V. 
Published: July 2021

An attempt to outline the contours of a new research field within the framework of the history of Russian journalism — the history of entrepreneurial journalism of the mid — second half of the 19th — early 20th centuries is presented. The publicistic work of Russian entrepreneurs of this time is interpreted by the authors as the forerunner of modern business journalism. It is shown that the key role in its constitution was played by the Great Reforms of the 1860s — 1870s, during which entrepreneurship became a collective actor in the emerging public (media) space and showed the ability to express and defend its interests, including through the printed word. It is noted that even then an array of non-professional entrepreneurial publications of various genres began to take shape, which subsequently evolved into an independent branch of journalistic creativity. It is pointed out that entrepreneurs-publicists remained primarily practitioners, people of action, which determined the special pragmatism of their texts, closely related to the “guild” and personal business interests. The authors come to the conclusion that when studying the journalistic creativity of entrepreneurs, not only logical coherence should be taken into account, but also the synchronicity of all forms of the author’s verbal creativity and his business activity.
Review of Current Research on Translanguaging as a Communicative Practice of Multilinguals
Authors: Golovko N. V. , Sheiko D. V. 
Published: July 2021

The issue of topical problems and promising areas of research of translanguaging as a communicative practice of multilinguals in English-language and Russian-language scientific publications of recent years is considered in the article. The results of a comparative analysis of scientific works on translanguaging, highlighting key supporting ideas and concepts, are presented. The novelty of the research is seen in the fact that modern publications on translanguaging as a communicative practice that have not yet been analyzed or sufficiently covered in similar review works are summarized. The relevance of the study is due to the fact that translanguaging is a new idea on a historical scale, which has gained significant popularity over the past years, which, in turn, causes the need to systematize and streamline the array of scientific works that have accumulated during this time. A review of the approaches proposed by various authors to the content of the concept of “translanguaging” in those cases when the latter is considered as a communicative practice is performed, as well as of the methodological principles and foundations on which various studies of translanguaging as a communicative practice are built. Based on the analysis of publications, possible problems and promising areas of research in translanguaging are highlighted.