bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS FAKTOR–FAKTOR YANG MEMPENGARUHI MASYARAKAT DALAM PENGEMBANGAN BANGUNAN RUMAH TIPE 36 (Studi Kasus Perumahan Surabaya Permai 4)
Authors: Ugizaqiah Olyvia , Supriani Fepy , Islam Mukhlis 
Published: May 2021

Abstract The increase of population caused the needed of home provider service. Mostly the housing already has it’s own type of house. As time goes by home developing happened in order to fullfill people needs. This study aimed to examine the factors that effect home development and find out the dominant factor for T36 h0use. The study uses descriptive survey methods and use multiple linear regression analysis to analyzed. Questionnaire were distributes to 41 respondents who lived in Surabaya Permai 4 Housing with 90% trust level. Processing questionnaire data using SPSS 25 with test requirements analysis, namely the validity and reliability test. The results of this research indicate that money, structural security, safety and comfort, social and culture, resident conditions, building condition effect 90.4% for home development. The most dominant factor affecting home development is the money factor with a percentage of 27.3%. The other factors are structural security 17.7%, safety and comfort 14.1%, social and culture 12.6%, resident condition 12.2% and building condition 6.5%. Keywords: house, home development, dominant factor
EVALUATION OF STRUCTURAL PERFORMANCE OF INSTALLATION BUILDING AND INPATIENT WARD IN DISTRICT HOSPITAL OF WATES USING SOFTWARE SAP-2000
Authors: Atmaka Aswin Andre 
Published: May 2021

This District Hospital of Wates was developed and constructed to meet medical need for local people of Kulon Progo District and this hospital was expected to have impact on the public economy wheel improvement. This hospital has a reinforced concrete structure to support the standing torque with five floors in 4.5-m height of each floor and has 20.5-m height. The building structure must be able to support earthquake force at specific level without significant damage of structure or, if the building must fail. The objective of this study was to find performance point value of the building, ratio drift value based on ATC-40 and performance level. This study evaluated the building performance of the hospital based on spectrum response and national standard of Indonesia. The results of study indicate that Performance Point value with X-direction slide force was 3188.541 kN and Y-direction was 1058.513. On the other hand, ratio drift value, based on ATC-40, had maximum in-elastic drift of X-direction = 0.000000249 and maximum In-elastic drift of Y-direction = 0.000000405, it means that the reviewed building was included in level of Immediate Occupancy (IO) so that the building of hospital, when earthquake faced it, did not experience structural and non-structural damage; therefore, this building remained safe. Keywords : Pushover, Perfomance Point , Ratio Drift, ATC-40
Análises das autorizações de procedimentos de alta complexidade de medicamentos para pacientes transplantados renais do Estado do Rio de Janeiro
Authors: Passos Márcia Maria Barros dos , Barbosa Gabriela Santos , Costa Milene Rangel da 
Published: May 2021

A terapia imunossupressora de manutenção é administrada a quase todos os receptores de transplante renal para ajudar a prevenir a rejeição aguda e a perda do enxerto renal entre indivíduos geneticamente diferentes. O presente trabalho teve por objetivo analisar a dispensação de medicamentos do Componente Especializado da Assistência Farmacêutica para o tratamento de pacientes submetidos a transplante renal no Estado do Rio de Janeiro no período de 2008 a 2013. Com este propósito foi conduzido estudo descritivo que incluiu 156.527 registros de APAC de medicamentos selecionados para transplantes renais. Os resultados demonstraram que 55,7% das APAC geradas foram para pacientes do sexo masculino, sendo 28,1% para pacientes na faixa etária de 40 a 49 anos. 78,4% das APAC produzidas foram para pacientes que residiam em municípios da região metropolitana do Estado do Rio de Janeiro. O principal diagnóstico secundário foi doença renal crônica (30,9%). O grupo químico que mais gerou APAC foi dos antiproliferativos, com o micofenolato de mofetila em maior quantidade. Dentre os outros grupos químicos, inibidores de calcineurina e inibidores de rapamicina, os medicamentos que mais geraram APAC foram respectivamente tacrolimo e sirolimo. Existem poucos estudos de utilização de medicamentos sobre manutenção do transplante renal no Brasil. Os resultados observados indicam que os medicamentos que mais foram dispensados não são os medicamentos indicados de primeira escolha para o tratamento de manutenção do transplante renal. Este resultado permitiu ter um perfil dos medicamentos que tem maior impacto no tratamento do paciente em terapia de manutenção do transplante renal, o que pode ajudar para planejamentos futuros de assistência farmacêutica no SUS.
Gestão estratégica de materiais: Uma proposta através da Matriz de Kraljic e da teoria dos jogos
Authors: Lima Douglas Leonardo de , Santos Osmildo Sobral dos , Coutinho Aparecido dos Reis 
Published: May 2021

Analisando o cenário de competitividade entre as empresas, o setor de compras tornou-se um setor estratégico, assim, é possível perceber a constate busca das organizações por modelos estratégicos que possibilitem um alinhamento com os resultados esperados pelas corporações. O presente artigo busca propor um método alternativo para gestão estratégica na aquisição de materiais e serviços, através do modelo de compras criado por Peter Kraljic, que analisou os materiais a partir dos impactos financeiros causados por eles e os risco de suprimentos que estes representam. Junto a isto é proposto a utilização da Teoria dos Jogos, como estratégia de jogo a ser jogado para cada grupo de material. Para isto, o método de pesquisa utilizado foi o método hipotético-dedutivo, bem como a revisão da literatura, feita através da leitura de livros, revistas e periódicos que relatam e relacionam-se com o assunto. Ao final um dos resultados observados é uma matriz estratégica para aquisição de materiais, onde para cada grupo de materiais, após classificados quanto ao risco financeiro e risco de suprimento é proposto um tipo de jogo. Entretanto, observa-se que o campo de estudo é muito vasto e passível de novos estudos.
Sosialisasi Pencegahan Stunting pada Anak Balita di Kelurahan Cawang Jakarta Timur
Authors: Damanik Sri Melfa , Sitorus Erita , Mertajaya I Made 
Published: May 2021

Stunting merupakan salah satu kondisi gagal tumbuh pada anak dimana tinggi badan anak <-2SD menurut tabel Z-score WHO. Ada beberapa hal yang menjadi penyebab utama masalah stunting pada anak, salah satunya yaitu ketidakoptimalan praktik pemberian makan anak. Tujuan Pelaksanaan Pengabdian kepada Masyarakat (PKM) ini yaitu untuk meningkatkan pengetahuan dan ketrampilan ibu tentang pencegahan stunting melalui edukasi praktik pemberian makan yang tepat berdasarkan rekomendasi WHO. Sebanyak 40 ibu yang memiliki anak Balita ikut dalam kegiatan PKM. Metode pelaksanaan PKM yaitu sosialisasi yang dikombinasikan dengan survei secara kuantitatif tentang pelaksanaan praktek pemberian yang dilakukan oleh ibu berdasarkan indikator praktik pemberian makan menurut rekomendasi WHO. Hasil PKM menunjukkan terdapat perbedaan yang signifikan antara nilai pre dan posttest peserta setelah diberikan sosialisasi di Kelurahan Cawang, Jakarta timur (P<0,001) dan 90 % ibu mengalami peningkatan pengetahuan. Pemahaman ibu yang memiliki anak Balita tentang pencegahan stunting melalui pemberian makanan yang tepat dapat menurunkan risiko masalah stunting di Indonesia.
Excitation Conditions for Surface-Enhanced Hyper Raman Scattering With Biocompatible Gold Nanosubstrates
Authors: Dusa Arpad , Madzharova Fani , Kneipp Janina 
Published: May 2021

Surface enhanced hyper Raman scattering (SEHRS) can provide many advantages to probing of biological samples due to unique surface sensitivity and vibrational information complementary to surface-enhanced Raman scattering (SERS). To explore the conditions for an optimum electromagnetic enhancement of SEHRS by dimers of biocompatible gold nanospheres and gold nanorods, finite-difference time-domain (FDTD) simulations were carried out for a broad range of excitation wavelengths from the visible through the short-wave infrared (SWIR). The results confirm an important contribution by the enhancement of the intensity of the laser field, due to the two-photon, non-linear excitation of the effect. For excitation laser wavelengths above 1,000 nm, the hyper Raman scattering (HRS) field determines the enhancement in SEHRS significantly, despite its linear contribution, due to resonances of the HRS light with plasmon modes of the gold nanodimers. The high robustness of the SEHRS enhancement across the SWIR wavelength range can compensate for variations in the optical properties of gold nanostructures in real biological environments.
Cell Type-Specific Differentiation Between Indica and Japonica Rice Root Tip Responses to Different Environments Based on Single-Cell RNA Sequencing
Authors: Wang Zhe , Cheng Daofu , Fan Chengang , Zhang Cong , Zhang Chao , Liu Zhongmin 
Published: May 2021

Background: As Oryza sativa ssp. indica and Oryza sativa ssp. japonica are the two major subspecies of Asian cultivated rice, the adaptative evolution of these varieties in divergent environments is an important topic in both theoretical and practical studies. However, the cell type-specific differentiation between indica and japonica rice varieties in response to divergent habitat environments, which facilitates an understanding of the genetic basis underlying differentiation and environmental adaptation between rice subspecies at the cellular level, is little known.Methods: We analyzed a published single-cell RNA sequencing dataset to explore the differentially expressed genes between indica and japonica rice varieties in each cell type. To estimate the relationship between cell type-specific differentiation and environmental adaptation, we focused on genes in the WRKY, NAC, and BZIP transcription factor families, which are closely related to abiotic stress responses. In addition, we integrated five bulk RNA sequencing datasets obtained under conditions of abiotic stress, including cold, drought and salinity, in this study. Furthermore, we analyzed quiescent center cells in rice root tips based on orthologous markers in Arabidopsis.Results: We found differentially expressed genes between indica and japonica rice varieties with cell type-specific patterns, which were enriched in the pathways related to root development and stress reposes. Some of these genes were members of the WRKY, NAC, and BZIP transcription factor families and were differentially expressed under cold, drought or salinity stress. In addition, LOC_Os01g16810, LOC_Os01g18670, LOC_Os04g52960, and LOC_Os08g09350 may be potential markers of quiescent center cells in rice root tips.Conclusion: These results identified cell type-specific differentially expressed genes between indica-japonica rice varieties that were related to various environmental stresses and provided putative markers of quiescent center cells. This study provides new clues for understanding the development and physiology of plants during the process of adaptative divergence, in addition to identifying potential target genes for the improvement of stress tolerance in rice breeding applications.
Potential Role of Macrophage Phenotypes and CCL2 in the Pathogenesis of Takayasu Arteritis
Authors: Kong Xiufang , Xu Ming , Cui Xiaomeng , Ma Lingying , Cheng Huiyong , Hou Jun , Sun Xiaoning , Ma Lili , Jiang Lindi 
Published: May 2021

ObjectivesTo investigate vascular macrophage phenotype as well as vascular and peripheral chemokine (C-C motif) ligand 2 (CCL2) expression during different stages of disease progression in patients with Takayasu Arteritis (TA).MethodsIn this study, 74 patients with TA and 50 controls were recruited. TA disease activity was evaluated with Kerr scores. Macrophage phenotype and CCL2 expression were examined by immunohistochemistry in vascular specimens from 8 untreated and 7 treated TA patients, along with 4 healthy controls. Serum CCL2 were quantified by enzyme-linked immune-absorbent assay from TA patients at baseline (n=59), at 6-months (n=38), and from 46 healthy volunteers. Vascular macrophage phenotype, vascular CCL2 expression and serum CCL2 levels during different stages, as well as the relationship between serum CCL2 and disease activity or other inflammatory parameters (erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and interleukin 6 (IL-6)) were investigated.ResultsIn untreated patients, vascular M1 macrophages and CCL2 showed increased expression, mainly in the adventitia. In contrast, in treated patients, vascular adventitial M1 and CCL2 expression were decreased, while vascular medial M2 macrophages and CCL2 levels were increased. Distribution of macrophages and CCL2 was consistent within the TA vascular lesions regardless of the disease stage. Furthermore, peripheral CCL2 was elevated in patients with TA (TA: 160.30 ± 120.05 vs. Control: 65.58 ± 54.56 pg/ml, P &lt; 0.001). CCL2 levels were found to correlate with ESR, CRP, and IL-6 (all R values between 0.55 and 0.6, all P &lt; 0.001). Receiver operating curve analysis demonstrated that CCL2 (at the cut-off value of 100.36 pg/ml) was able to predict disease activity (area under the curve = 0.74, P = 0.03). Decrease in CCL2 level was observed in patients with clinical remission (CR), but not in patients without CR, after 6 months of treatment (CR patients: baseline 220.18 ± 222.69 vs. post-treatment 88.71 ± 55.89 pg/ml, P = 0.04; non-CR patients: baseline 142.45 ± 104.76 vs. post-treatment 279.49 ± 229.46 pg/ml, P = 0.02).ConclusionsMacrophages contribute to vascular pathological changes in TA by undergoing phenotype transformation. CCL2 is an important factor for recruiting macrophages and a potential biomarker for disease activity.
Substrate Specificities and Inhibition Pattern of the Solute Carrier Family 10 Members NTCP, ASBT and SOAT
Authors: Grosser Gary , Müller Simon Franz , Kirstgen Michael , Döring Barbara , Geyer Joachim 
Published: May 2021

Three carriers of the solute carrier family SLC10 have been functionally characterized so far. Na+/taurocholate cotransporting polypeptide NTCP is a hepatic bile acid transporter and the cellular entry receptor for the hepatitis B and D viruses. Its intestinal counterpart, apical sodium-dependent bile acid transporter ASBT, is responsible for the reabsorption of bile acids from the intestinal lumen. In addition, sodium-dependent organic anion transporter SOAT specifically transports sulfated steroid hormones, but not bile acids. All three carriers show high sequence homology, but significant differences in substrate recognition that makes a systematic structure-activity comparison attractive in order to define the protein domains involved in substrate binding and transport. By using stably transfected NTCP-, ASBT-, and SOAT-HEK293 cells, systematic comparative transport and inhibition experiments were performed with more than 20 bile acid and steroid substrates as well as different inhibitors. Taurolithocholic acid (TLC) was identified as the first common substrate of NTCP, ASBT and SOAT with Km values of 18.4, 5.9, and 19.3 µM, respectively. In contrast, lithocholic acid was the only bile acid that was not transported by any of these carriers. Troglitazone, BSP and erythrosine B were identified as pan-SLC10 inhibitors, whereas cyclosporine A, irbesartan, ginkgolic acid 17:1, and betulinic acid only inhibited NTCP and SOAT, but not ASBT. The HBV/HDV-derived myr-preS1 peptide showed equipotent inhibition of the NTCP-mediated substrate transport of taurocholic acid (TC), dehydroepiandrosterone sulfate (DHEAS), and TLC with IC50 values of 182 nM, 167 nM, and 316 nM, respectively. In contrast, TLC was more potent to inhibit myr-preS1 peptide binding to NTCP with IC50 of 4.3 µM compared to TC (IC50 = 70.4 µM) and DHEAS (IC50 = 52.0 µM). Based on the data of the present study, we propose several overlapping, but differently active binding sites for substrates and inhibitors in the carriers NTCP, ASBT, SOAT.
Transvesical Retzius-Sparing Versus Standard Robot-Assisted Radical Prostatectomy: A Retrospective Propensity Score-Adjusted Analysis
Authors: Deng Wen , Jiang Hao , Liu Xiaoqiang , Chen Luyao , Liu Weipeng , Zhang Cheng , Zhou Xiaochen , Fu Bin , Wang Gongxian 
Published: May 2021

ObjectivesTo estimate the safety and efficiency of transvesical Retzius-sparing robot-assisted radical prostatectomy (T-RARP) compared with standard robot-assisted radical prostatectomy (S-RARP) for localized prostate cancer (PCa).Materials and Methods174 patients bearing localized PCa and undergoing T-RARP or S-RARP between October 2017 and January 2020 were retrospectively enrolled in our analysis. All potential baseline confounders were strictly restrained with propensity-score matching (PM) method (1: 1). Within the matched setting, the perioperative and functional outcomes were compared between the T-RARP and S-RARP groups, while the oncological results and functional recovery of the two arms were presented with Kaplan-Meier curves.ResultsFinally, 114 and 60 eligible patients harbouring localized PCa were identified in the S-RARP and T-RARP group, respectively. No significant differences between the two groups were found in all baseline characteristics after PM. Within the matched cohort, no case was converted to open surgery in either group. The T-RARP group was significantly related to a higher mean operative time (p = 0.001) and shorter median hospital stay length (p &lt; 0.001). There were not significant differences in the median estimated blood loss and specimen Gleason score between the two arms. The proportions of transfusion, pT3a disease, postoperative complication, and positive surgical margin in the T-RARP group were also comparable to that in the S-RARP group. The mean prostate-specific antigen and median erectile functional scores did not differ significantly between the two groups at postoperative 3 months and last follow-up. T-RARP vs. S-RARP had significantly improved urinary continence (UC) rates at the removal of catheter (p &lt; 0.001) and postoperative 3 months (p &lt; 0.001), but the significant difference between the two groups in UC recovery disappeared at last follow-up (p = 0.119). No significant difference in biochemical recurrence-free survival was observed following the two surgeries (p = 0.727).ConclusionsT-RARP by experienced hands was feasible for selected patients with clinically localized PCa, yielding significantly improved early return to UC and similar erectile functional preservation without compromising oncological control when compared with the standard approach.
A Systematic Review of Momentary Assessment Designs for Mood and Anxiety Symptoms
Authors: Hall Mila , Scherner Paloma V. , Kreidel Yannic , Rubel Julian A. 
Published: May 2021

Background:Altering components of ecological momentary assessment (EMA) measures to better suit the purposes of individual studies is a common and oftentimes necessary step. Though the inherent flexibility in EMA has its benefits, no resource exists to provide an overview of the variability in how convergent constructs and symptoms have been assessed in the past. The present study fills that gap by examining EMA measurement design for mood and anxiety symptomatology.Methods:Various search engines were used to identify 234 relevant studies. Items administered, data collection schedules (i.e., beeps per day), response scales (i.e., Likert), data collection platforms (i.e., apps), and psychometric properties (i.e., reliability) were extracted.Results:Study designs varied greatly in all aspects across the identified papers. Over 4,600 extracted items were qualitatively analyzed, resulting in the identification of 12 themes. The most EMA items focused on affect, with categories such as “happiness” and “tension” appearing most frequently. We provide all of our data extraction in the format of an open-source database.Limitations:Despite our best attempts to include as much of the relevant literature as possible, this review and the accompanying database are not exhaustive, but can easily be built upon to include other, newer studies.Conclusions:The fact that the affect theme featured both positive and negative emotional constructs highlights the dichotomous focus on valence and affect within the literature surrounding anxious and depressive symptomatology. We hope that our database will act as a helpful design decision-making resource for researchers studying this kind of symptomatology in the future.Systematic Review Registration:PROSPERO (CRD42019139409).
Long-Term Outcome of Adolescent Anorexia Nervosa: Family Treatment Apartments Compared With Child Psychiatric Inpatient Treatment
Authors: Wallin Ulf , Holmer Riitta 
Published: May 2021

Introduction: The family is rarely involved in treatment when the patient with anorexia nervosa (AN) is hospitalized. Family treatment apartment (FTA) represents an intervention that includes the family in the intensive treatment of AN. This study compares the short- and long-term outcomes of adolescents treated in FTA with those who received inpatient hospital care. In FTA, the parents are responsible for providing meal support, whereas in hospital care, the staff is responsible.Methods: Sixty-eight previous patients admitted during the period 1990–2009 participated in a follow-up, 43 from the FTA where the whole family is admitted for treatment and 25 from regular psychiatric inpatient care. The follow-up consisted of a personal meeting with structured interviews, measurement of height and weight, and self-rating questionnaires.Result: Readmissions due to weight loss within 6 months from discharge were less common in the FTA group. At follow-up, 14.2 years after admission, there was no difference in eating disorder pathology between the groups. There were significantly lower scores on general psychiatric pathology and significantly higher scores on quality of life in the FTA group.Discussion: The treatment in FTA aims to give the family the ability to handle AN when it is most challenging. FTA may thus provide a helpful context for treatment with a basic sense of security along with skills that could contribute to better general mental health at follow-up.