bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rhopressa-induced corneal edema: a case report
Authors: Chu Matthew J. , Song Michael , Palmares Trisa , Song Alice , Song Julia 
Published: April 2021

Abstract
Background
Rhopressa (netarsudil) has recently been added to the arsenal of treatment for open-angle glaucoma. It is an effective norepinephrine transporter and Rho-associated protein kinase (ROCK) inhibitor used to decrease intraocular pressure (IOP), with the most common side effect being conjunctival hyperemia.

Case presentation
We report a unique case of Rhopressa-induced corneal edema in a 79-year-old African-American woman, which resolved after discontinuation. She had a history of smoking one cigarette per day and did not consume alcohol. She had no history of corneal edema or uveitis.

Conclusions
Previous case reports have documented patients with Rhopressa-induced corneal edema; however, they have all had a preexisting history of corneal edema or uveitis. We believe that this is a unique case of Rhopressa-induced corneal edema in a relatively healthy eye. While Rhopressa is effective in managing glaucoma, there may be effects of treatment that are still unknown. We will discuss clinical findings of our case, along with a review of previous literature on Rhopressa and novel ROCK inhibitors. We hope that we can add to the existing body of literature and invite further investigation of Rhopressa and ROCK inhibitors and their effects on the cornea.
Iterative guided machine learning-assisted systematic literature reviews: a diabetes case study
Authors: Zimmerman John , Soler Robin E. , Lavinder James , Murphy Sarah , Atkins Charisma , Hulbert LaShonda , Lusk Richard , Ng Boon Peng 
Published: April 2021

Abstract
Background
Systematic Reviews (SR), studies of studies, use a formal process to evaluate the quality of scientific literature and determine ensuing effectiveness from qualifying articles to establish consensus findings around a hypothesis. Their value is increasing as the conduct and publication of research and evaluation has expanded and the process of identifying key insights becomes more time consuming. Text analytics and machine learning (ML) techniques may help overcome this problem of scale while still maintaining the level of rigor expected of SRs.

Methods
In this article, we discuss an approach that uses existing examples of SRs to build and test a method for assisting the SR title and abstract pre-screening by reducing the initial pool of potential articles down to articles that meet inclusion criteria. Our approach differs from previous approaches to using ML as a SR tool in that it incorporates ML configurations guided by previously conducted SRs, and human confirmation on ML predictions of relevant articles during multiple iterative reviews on smaller tranches of citations. We applied the tailored method to a new SR review effort to validate performance.

Results
The case study test of the approach proved a sensitivity (recall) in finding relevant articles during down selection that may rival many traditional processes and show ability to overcome most type II errors. The study achieved a sensitivity of 99.5% (213 out of 214) of total relevant articles while only conducting a human review of 31% of total articles available for review.

Conclusions
We believe this iterative method can help overcome bias in initial ML model training by having humans reinforce ML models with new and relevant information, and is an applied step towards transfer learning for ML in SR.
Maternal body condition during late-pregnancy is associated with in utero development and neonatal growth of Holstein calves
Authors: Alharthi A. S. , Coleman D. N. , Alhidary I. A. , Abdelrahman M. M. , Trevisi E. , Loor J. J. 
Published: April 2021

Abstract
Background
Nutritional management in the dry period can alter body condition score (BCS) in dairy cows, a subjective measure of body fat. As such, differences in BCS during late-pregnancy not only mirror nutrient utilization by fat depots, but also can play important roles on the metabolic and hormonal environment. We investigated the association between cow BCS during late-pregnancy on developmental parameters and blood variables of neonatal calves. Forty-nine multiparous Holstein cows were retrospectively divided by prepartal BCS into normal BCS ≤3.25 (NormBCS; 3.02 ± 0.17, n = 30) or high BCS ≥3.75 (HighBCS; 3.83 ± 0.15, n = 19) groups. Plasma samples were collected from cows at − 10 d relative to parturition. Body weight, hip and wither height, hip width and body length were measured at birth and weekly through weaning (42 d of age) and until 9 weeks of age. Calf blood samples were collected from the jugular vein at birth (before receiving colostrum, 0 d), 24 h after first colostrum and at 7, 21, 42 and 50 d of age. The data were subjected to ANOVA using the mixed procedure of SAS. The statistical model included day, BCS, and their interactions.

Results
Dry matter intake (kg/d or % of body weight) during the last 4 weeks of pregnancy was lower (P ≤ 0.06) in HighBCS cows. Plasma concentrations of fatty acids, ceruloplasmin, and nitric oxide were greater overall (P < 0.05) at d − 10 prior to calving in HighBCS cows, and they tended (P = 0.08) to have greater concentrations of reactive oxygen metabolites. Birth body weight was lower (P = 0.03) in calves born to dams with HighBCS. In addition, plasma concentrations of fatty acids, albumin and urea (P < 0.05) were greater in those calves. Although calves born to cows with HighBCS maintained a lower postnatal body weight (P = 0.04), hip and wither height, hip width, and body length, there was no difference (P > 0.05) in daily starter intake and average daily gain due to maternal BCS.

Conclusions
Overall, results highlight an association between BCS during late-gestation on in utero calf development and postnatal growth. A high maternal BCS during late-gestation was associated with lower calf body weights, which could be due to lower maternal intakes and a state of inflammation and metabolic stress.
Ultrasonic bone removal from the ossicular chain affects cochlear structure and function
Authors: Siu Jennifer M. , Negandhi Jaina , Harrison Robert V. , Wolter Nikolaus E. , James Adrian 
Published: April 2021

Introduction Ultrasonic bone removal devices (UBD) are capable of cutting through bony tissue without injury to adjacent soft tissue. The feasibility and safety of using this technology for removal of bone from an intact ossicular chain (as might be required for otosclerosis or congenital fixation) was investigated in an animal model. Methods This was a prospective animal study conducted on seven anesthetised adult chinchillas. An UBD was used to remove bone from the malleus head in situ. Pre and post-operative distortion product otoacoustic emission (DPOAE) levels and auditory brainstem response (ABR) thresholds were recorded. Scanning electron microscopy (SEM) was used to assess cochlear haircell integrity. Results Precise removal of a small quantity of bone from the malleus head was achieved by a 30s application of UBD without disruption of the ossicular chain or tympanic membrane. DPOAEs became undetectable after the intervention with signal-to-noise ratios (SNR) < 5 dB SPL in all ears. Furthermore, ABR thresholds were elevated > 85 dB SPL in 13 ears. SEM showed significant disruption of structural integrity of the organ of Corti, specifically loss and damage of outer haircells. Conclusions Although UBD can be used to reshape an ossicle without middle ear injury, prolonged contact with the ossicular chain can cause structural and functional injury to the cochlea. Extensive cochlea pathology was found, but we did not investigate for recovery from any temporary threshold shift. In the authors’ opinion, further study should be undertaken before consideration is given to use of the device for release of ossicular fixation. Graphical Abstract
Computing the Hazard Ratios Associated With Explanatory Variables Using Machine Learning Models of Survival Data
Authors: Sundrani Sameer , Lu James 
Published: April 2021

PURPOSE The application of Cox proportional hazards (CoxPH) models to survival data and the derivation of hazard ratio (HR) are well established. Although nonlinear, tree-based machine learning (ML) models have been developed and applied to the survival analysis, no methodology exists for computing HRs associated with explanatory variables from such models. We describe a novel way to compute HRs from tree-based ML models using the SHapley Additive exPlanation values, which is a locally accurate and consistent methodology to quantify explanatory variables’ contribution to predictions. METHODS We used three sets of publicly available survival data consisting of patients with colon, breast, or pan cancer and compared the performance of CoxPH with the state-of-the-art ML model, XGBoost. To compute the HR for explanatory variables from the XGBoost model, the SHapley Additive exPlanation values were exponentiated and the ratio of the means over the two subgroups was calculated. The CI was computed via bootstrapping the training data and generating the ML model 1,000 times. Across the three data sets, we systematically compared HRs for all explanatory variables. Open-source libraries in Python and R were used in the analyses. RESULTS For the colon and breast cancer data sets, the performance of CoxPH and XGBoost was comparable, and we showed good consistency in the computed HRs. In the pan-cancer data set, we showed agreement in most variables but also an opposite finding in two of the explanatory variables between the CoxPH and XGBoost result. Subsequent Kaplan-Meier plots supported the finding of the XGBoost model. CONCLUSION Enabling the derivation of HR from ML models can help to improve the identification of risk factors from complex survival data sets and to enhance the prediction of clinical trial outcomes.
The Geopolitics of Citizenship: Evidence from North Korean Claims to Citizenship in South Korea
Authors: Greitens Sheena Chestnut 
Published: April 2021

Abstract
North Koreans have a constitutionally guaranteed right to citizenship in the Republic of Korea and high coethnic communitarian affinity; as such, they are often described as having automatic citizenship in South Korea. This article demonstrates that portrayals of automatic citizenship are problematic. North Koreans have often struggled to acquire state recognition when making claims to citizenship from abroad, and acquisition of ROK citizenship remains an incremental and contingent process, one that requires a high degree of agency from North Koreans seeking resettlement. This article draws on analysis of approximately 120 North Korean memoirs published in Korean and English, as well as other documentary and interview evidence. It finds that although citizenship is typically thought of as membership within a political community, it is also an identity practiced, claimed, and negotiated externally. Moreover, extraterritorial negotiations over citizenship recognition can be strongly influenced by state geopolitical and security considerations.
Anxiety and its role for cognitive changes in patients after coronary artery bypass grafting
Authors: Eremina Daria 
Published: April 2021

Aim of the studySeveral psychosocial characteristics are well known to be importantly related to coronary heart disease (CHD). However, psychological aspects of surgical treatment of CHD and its implications for rehabilitation perspectives and cognitive changes of cardiac patients remain poorly understood.
The article presents the results of studying the dynamics of emotional state of patients after coronary artery bypass grafting (CABG), measured before the surgery and at different stages of the rehabilitation process, and on a comparative analysis of trait and state anxiety and alexithymia of patients with CHD with different cognitive dynamics.Subject or material and methods118 patients with CHD, undergoing CABG were examined (average age 59,86 ± 7,31 years). The study was conducted using the clinical and psychological method and a specially developed complex of pato- and neuropsychological methods for assessing various spheres of cognitive functioning and emotional state of the patients.ResultsIt was shown that patients with cognitive impairment are characterized by great anxiety in the field of social contacts and an understanding of the social sphere as the main source of anxiety stress and uncertainty in itself. Patients complaining about the state of the cognitive sphere generally have a greater degree of personal anxiety, a feeling of emotional discomfort, dissatisfaction with life situations, and increased anxiety in the field of social contacts.DiscussionMost differences in the emotional state of patients with different cognitive dynamics were found even before surgery.ConclusionsTherefore, it seems reasonable to introduce additional short-term psychotherapeutic interventions aimed at stabilizing the emotional state of patients preparing for CABG surgery.
The Value of Personalized Pricing
Authors: Elmachtoub Adam N. , Gupta Vishal , Hamilton Michael L. 
Published: April 2021

Increased availability of high-quality customer information has fueled interest in personalized pricing strategies, that is, strategies that predict an individual customer’s valuation for a product and then offer a price tailored to that customer. Although the appeal of personalized pricing is clear, it may also incur large costs in the forms of market research, investment in information technology and analytics expertise, and branding risks. In light of these trade-offs, our work studies the value of personalized pricing strategies over a simple single-price strategy. We first provide closed-form lower and upper bounds on the ratio between the profits of an idealized personalized pricing strategy (first-degree price discrimination) and a single-price strategy. Our bounds depend on simple statistics of the valuation distribution and shed light on the types of markets for which personalized pricing has little or significant potential value. Second, we consider a feature-based pricing model where customer valuations can be estimated from observed features. We show how to transform our aforementioned bounds into lower and upper bounds on the value of feature-based pricing over single pricing depending on the degree to which the features are informative for the valuation. Finally, we demonstrate how to obtain sharper bounds by incorporating additional information about the valuation distribution (moments or shape constraints) by solving tractable linear optimization problems. This paper was accepted by David Simchi-Levi, revenue management and market analytics.
Low-Wage Workers and the Enforceability of Noncompete Agreements
Authors: Lipsitz Michael , Starr Evan 
Published: April 2021

We exploit the 2008 Oregon ban on noncompete agreements (NCAs) for hourly-paid workers to provide the first evidence on the impact of NCAs on low-wage workers. We find that banning NCAs for hourly workers increased hourly wages by 2%–3% on average. Since only a subset of workers sign NCAs, scaling this estimate by the prevalence of NCA use in the hourly-paid population suggests that the effect on employees actually bound by NCAs may be as great as 14%–21%, though the true effect is likely lower due to labor market spillovers onto those not bound by NCAs. Whereas the positive wage effects are found across the age, education, and wage distributions, they are stronger for female workers and in occupations where NCAs are more common. The Oregon low-wage NCA ban also improved average occupational status in Oregon, raised job-to-job mobility, and increased the proportion of salaried workers without affecting hours worked.This paper was accepted by Lamar Pierce, organizations.
Obstetrics and birth: effects of experiences and gender bias on student test scores
Authors: Keating Glen , Marsh Amy , Nhouyvanisvong Adisack , Mountfort Steven , Lawler Ron 
Published: April 2021

Objectives: Paramedic education requires all students have the experience of attending childbirth. Obstetric (OB) experiences are limited for students in hospitals and even more so in the field. Gender bias may exist in hospital OB rotations for paramedic students but research on this is limited. This study is intended to examine whether a sex bias exists in field or hospital placements and if that bias correlates to OB test scores. Methods: Using data from Fisdap, numbers of OB experiences were analysed and compared to individual student sex and experience type (hospital clinical, field or skills laboratory). The number of experiences were compared to that student's score on the OB section of the Fisdap paramedic readiness examinations version 3 (PRE3) or version 4 (PRE4). Results: Of 12 090 paramedic students, male (n=5625) and female (n=2682) students who took the PRE3 had equal average scores of 0.76 and male (n=2498) and female (n=1285) students who took the PRE4 had average scores of 0.77 and 0.79 respectively. Students who took the PRE3 saw a mean of 4.32 births, a majority of which were in hospital (3.68); there was minimal difference in experiences between male and female students in field or skills laboratory settings, but women saw more births in hospital settings (3.92) than men (3.43). Students who took the PRE4 saw a mean of 4.54 births, a majority of which were in hospital (3.8) and there was minimal difference in experiences between male and female students in field or laboratory settings but women students saw more births in hospital (4.06) than men (3.54). Conclusions There is no correlation between the number of OB emergency encounters by paramedic students and their OB test scores. However, a potential gender bias exists as female students tend to have more labour and birth experiences in hospital settings than their male counterparts, while number of experiences in lab and field settings were similar.
Intensity-correlated spiking of infrared and ultraviolet emission from sodium vapors
Authors: Akulshin Alexander , Pedreros Bustos Felipe , Budker Dmitry 
Published: April 2021

Temporal spiking of directional infrared and ultraviolet cooperative emission from sodium vapors excited to the

4

D

5

/

2

level with a continuous-wave resonant laser pump is analyzed. Mirrorless lasing at 2207 and 2338 nm on cascade population-inverted transitions and radiation at 330 nm generated due to four-wave mixing demonstrate a high degree of intensity correlation.
Meta-analysis of the prevalence of Echinococcus in dogs in China from 2010 to 2019
Authors: Gong Qing-Long , Ge Gui-Yang , Wang Qi , Tian Tian , Liu Fei , Diao Nai-Chao , Nie Lan-Bi , Zong Ying , Li Jian-Ming , Shi Kun , Leng Xue , Du Rui 
Published: April 2021

Background
Echinococcosis (canine Echinococcus disease) is a neglected tropical disease that causes serious public harm. Dogs, as a terminal host of Echinococcus spp., are a key part of the Echinococcus epidemic. Echinococcosis spreads easily in humans and animals in some areas of China and it is therefore necessary to fully understand the prevalence of Echinococcus spp. in dogs.

Methodology/Principal findings
PubMed, ScienceDirect, Chongqing VIP, China National Knowledge Infrastructure (CNKI), and WanFang databases were searched for relevant articles published in the past 10 years. A final total of 108 studies were included. The overall prevalence of Echinococcus spp. in dogs in China was 7.3%, with the highest point estimate found in sampling year 2015 (8.2%) and publication year 2015 (16.5%). Northwestern China (7.9%) had the highest infection rate in China. Qinghai Province (13.5%) showed the highest prevalence among the 11 provinces we included. We also found that geographical and climatic factors are related to the incidence of canine echinococcosis. We further investigated the source of heterogeneity by analysis of subgroups (sampling district, detection method, dog type, season, parasite species, medication, and study quality level).

Conclusions/Significance
Our research indicated that Echinococcus spp. were still prevalent in some areas in China. More localized prevention and control policies should be formulated, including improving drinking water hygiene and strengthening hygiene promotion. We recommend the rational use of anti-Echinococcus drugs. In addition, treatment of livestock offal and feces and improving the welfare of stray dogs may play an important role in reducing canine Echinococcus infections.
Strengthening individual and family resilience against leprosy-related discrimination: A pilot intervention study
Authors: van’t Noordende Anna T. , Bakirtzief da Silva Pereira Zoica , Biswas Pritha , Ilyas Mohammed , Krishnan Vijay , Parasa Jayaram , Kuipers Pim 
Published: April 2021

Background
Leprosy and leprosy-related stigma can have a major impact on psychosocial wellbeing of persons affected and their family members. Resilience is a process that incorporates many of the core skills and abilities which may enable people to address stigma and discrimination. The current study aimed to develop and pilot an intervention to strengthen individual and family resilience against leprosy-related discrimination.

Methodology
We used a quasi-experimental, before-after study design with a mixed methods approach. The 10-week family-based intervention was designed to strengthen the resilience of individuals and families by enhancing their protective abilities and capacity to overcome adversity. The study was conducted in two sites, urban areas in Telangana state, and in rural areas in Odisha state, India. Persons affected and their family members were included using purposive sampling. Two questionnaires were used pre-and post-intervention: the Connor-Davidson Resilience Scale (CD-RISC, maximum score 100, with high scores reflecting greater resilience) and the WHOQOL-BREF (maximum score of 130, with higher scores reflecting higher quality of life). In addition, semi-structured interviews were conducted post-intervention. Data were collected at baseline, a few weeks after completion of the intervention, and in the Odisha cohort again at six months after completion. Paired t-tests measured differences pre- and post- intervention. Qualitative data were thematically analysed.

Findings
Eighty participants across 20 families were included in the study (23 persons affected and 57 family members). We found a significant increase in CD-RISC scores for persons affected and family members from Odisha state (baseline 46.5, first follow-up 77.0, second follow-up 70.0), this improvement was maintained at six-month follow-up. There was no increase in CD-RISC scores post-intervention among participants from Telangana state. WHOQOL-BREF scores were significantly higher at follow-up for persons affected in both states, and for family members in Odisha state. No families dropped out of the study. In the qualitative feedback, all participants described drawing benefit from the programme. Participants especially appreciated the social dimensions of the intervention.

Conclusion
This pilot study showed that the 10-week family-based intervention to strengthen resilience among persons affected by leprosy and their family members was feasible, and has the potential to improve resilience and quality of life. A large-scale efficacy trial is necessary to determine the effectiveness and long-term sustainability of the intervention.