bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychedelic drugs and perception: a narrative review of the first era of research
Authors: Aday Jacob S. , Wood Julia R. , Bloesch Emily K. , Davoli Christopher C. 
Published: February 2021

Abstract
Psychedelic drugs are well-known for transiently altering perception, and in particular, for their visual effects. Although scientific interest into the substances’ effects on perception increased during the first era of psychedelic research during the early to mid-20th century, there is currently no source where these findings have been synthesized. In addressing this gap, the current narrative review found that psychedelics were examined for their influences across all levels of the visual system (e.g., retinal, cortical, subcortical, simple visual processing, complex imagery, hallucinations). Psychedelics were also shown to affect auditory discrimination/generalization, neural correlates of auditory processing, and led to auditory hallucinations in subsets of participants. Several studies demonstrated that psychedelics can distort representations of body schema and time perception. Concerns regarding methodological standards of this era are a limitation to the findings and are discussed. Collectively, this review preserves and increases the accessibility of the work done by pioneering psychedelic/perception researchers, synthesizes findings, and critically analyzes areas of discrepancy to inform future studies.
Optogenetic and chemogenetic modulation of astroglial secretory phenotype
Authors: Salmina Alla B. , Gorina Yana V. , Erofeev Alexander I. , Balaban Pavel M. , Bezprozvanny Ilya B. , Vlasova Olga L. 
Published: February 2021

Abstract
Astrocytes play a major role in brain function and alterations in astrocyte function that contribute to the pathogenesis of many brain disorders. The astrocytes are attractive cellular targets for neuroprotection and brain tissue regeneration. Development of novel approaches to monitor and to control astroglial function is of great importance for further progress in basic neurobiology and in clinical neurology, as well as psychiatry. Recently developed advanced optogenetic and chemogenetic techniques enable precise stimulation of astrocytes in vitro and in vivo, which can be achieved by the expression of light-sensitive channels and receptors, or by expression of receptors exclusively activated by designer drugs. Optogenetic stimulation of astrocytes leads to dramatic changes in intracellular calcium concentrations and causes the release of gliotransmitters. Optogenetic and chemogenetic protocols for astrocyte activation aid in extracting novel information regarding the function of brain’s neurovascular unit. This review summarizes current data obtained by this approach and discusses a potential mechanistic connection between astrocyte stimulation and changes in brain physiology.
Progression of Gait Changes in Older Adults With Mild Cognitive Impairment: A Systematic Review
Authors: Masse Fernando Arturo Arriagada , Ansai Juliana Hotta , Fiogbe Elie , Rossi Paulo Giusti , Vilarinho Ana Carolina Gonçalves , Takahashi Anielle Cristhine de Medeiros , Pires de Andrade Larissa 
Published: February 2021

Background and Purpose:
The identification of altered gait and its progression over time is important to gaining a better understanding of the clinical aspects of mild cognitive impairment (MCI) in older adults. The aim of the present systematic review was to determine changes in gait variables over time among older adults with MCI.

Methods:
The PubMed, Web of Science, Scopus, and Science Direct databases were searched for relevant articles using the following keywords and Medical Subject Headings: Aged AND “Mild cognitive impairment” AND (gait OR locomotion). A hand search was also performed of the reference lists of the selected articles in an attempt to find additional records. The following were the inclusion criteria: longitudinal studies and clinical trials involving a control group without intervention; samples of individuals 65 years or older; and characterization of gait using a single or dual task.

Results and Discussion:
The initial search led to the retrieval of 6979 studies, 9 of which met the inclusion criteria. The duration of follow-up among the studies ranged from 6 months to 2 years. Most trials investigated gait speed. Other gait variables were step length, time required to walk a given distance, and mean weekly gait speed. Altered gait progressed in older adults with MCI. The main alterations were gait speed and variability in daily number of steps in follow-up periods lasting more than 1 year. No significant changes in gait variables were found in shorter follow-up periods (up to 6 months).

Conclusions:
The progression of gait changes in older adults with MCI has been underinvestigated. MCI leads to reduced gait speed in longer follow-up periods. Such information can contribute to the determination of motor interventions for older adults with MCI, especially in the early stages.
Mixed-Methods Approach to Understanding Determinants of Practice Change in Skilled Nursing Facility Rehabilitation: Adapting to and Sustaining Value With Postacute Reform
Authors: Gustavson Allison M. , LeDoux Cherie V. , Stutzbach Julie A. , Miller Matthew J. , Seidler Katie J. , Stevens-Lapsley Jennifer E. 
Published: February 2021

Background and Purpose:
Postacute care reform is driving physical and occupational therapists in skilled nursing facilities (SNFs) to change how they deliver care to produce better outcomes in less time. However, gaps exist in understanding determinants of practice change, which limits translation of evidence into practice. This study explored what determinants impacted change in care delivery at 2 SNFs that implemented a high-intensity resistance training intervention.

Methods:
We used a mixed-methods, sequential explanatory design to explain quantitative findings using qualitative methods with a multiple-case study approach. Quantitative data were collected on therapists' attitudes toward evidence-based practice and aspects of intervention implementation. We conducted focus groups with therapists (N = 15) at 2 SNFs, classified as either high- (SNF-H) or low-performing (SNF-L) based on implementation fidelity and sustainability.

Results and Discussion:
Determinants of SNF rehabilitation practice change included the organizational system, team dynamics, patient and therapist self-efficacy, perceptions of intervention effectiveness, and ability to overcome preconceived notions. A patient-centered system, positive team dynamics, and ability to overcome preconceived notions fostered practice change at SNF-H. While self-efficacy and perception of effectiveness positively impacted change in practice at both SNFs, these determinants were not enough to overcome challenges at SNF-L. To adapt to changes and sustain rehabilitation value, further research must identify the combination of determinants that promote application of evidence-based practice.

Conclusions:
This study is the first step in understanding what drives change in SNF rehabilitation practice. As SNF rehabilitation continues to face changes in health care delivery and reimbursement, therapists will need to adapt, by changing practice patterns and adopting evidence-based approaches, to demonstrate value in postacute care.
Use of Backward Walking Speed to Screen Dynamic Balance and Mobility Deficits in Older Adults Living Independently in the Community
Authors: Taulbee Logan , Yada Trishia , Graham Lauren , O'Halloran Allison , Saracino Dawn , Freund Jane , Vallabhajosula Srikant , Balasubramanian Chitralakshmi K. 
Published: February 2021

Background and Purpose:
Older adults who live independently in the community are higher functioning and routinely ambulate in the community. Unrestricted community ambulation increases the likelihood of encountering precarious situations challenging balance. Sufficient dynamic balance is necessary to avoid falls. Currently used balance and mobility assessments may not sufficiently challenge dynamic balance to uncover mobility deficits in independent community-dwelling older adults. The purpose of this study was to investigate whether backward walking speed (BWS) can serve as an outcome measure to screen dynamic balance and mobility deficits in independent community-dwelling older adults.

Methods:
A convenience sample of 30 older adults (73.68 ± 6.54 years) participated in this cross-sectional study. Participants walked backward on an instrumented walkway to record BWS. Other outcomes included forward walking speed (FWS), Community Balance and Mobility (CB&M) Scale, Falls Efficacy Scale-International (FES-I), Timed Up and Go (TUG) test, and 7-day average step count (ASC). A multivariate analysis of variance investigated the overall group differences between older adults at fall risk and those not at risk and was followed up by univariate tests. Pearson and spearman coefficients investigated associations between study outcomes. Youden's index assessed diagnostic accuracy.

Results and Discussion:
Backward walking speed, CB&M, FES-I, ASC discriminated older adults at fall risk from those not at risk (P < .01) whereas FWS and TUG did not. Backward walking speed strongly correlated with challenging assessments of balance and mobility (CB&M, FES-I, and ASC) but only moderately correlated with the TUG. The CB&M Scale independently explained 53% variance in the BWS performance (P < .01). Youden's index was highest (Y = 0.6, sensitivity = 93%, and specificity = 67%) for BWS (0.73 m/s) compared with other study outcomes.

Conclusions:
Preliminary results suggest that BWS can screen for dynamic balance and mobility deficits in independent community-dwelling older adults. Accurate screening is the first step to capture early decline in function for independent community-dwelling older adults. Longitudinal follow-up studies are warranted to validate BWS as a screening tool.
TRANSICIÓN EPITELIO-MESÉNQUIMA INDUCIDA POR VIRUS
Authors: Hincapie Victoria , Gallego-Gómez Juan Carlos 
Published: February 2021

La Transición Epitelio-Mesénquima (EMT) es un proceso de dediferenciación altamente conservado en vertebrados. Este ocurre en células epiteliales con la activación progresiva de la pérdida de la polaridad, la adquisición de motilidad individual y la capacidad invasiva a otros tejidos. La EMT es un proceso normal durante el desarrollo; no obstante, en condiciones patológicas está relacionada con la inducción de metástasis, lo cual representa una vía alterna al desarrollo de procesos oncogénicos tempranos. Aunque la EMT es activada principalmente por factores de crecimiento, también se puede desencadenar por infecciones de patógenos intracelulares mediante la activación de rutas moleculares inductoras de este proceso. Por lo tanto, una infección bacteriana o viral pueda generar predisposición al desarrollo de tumores. Nuestro interés está enfocado principalmente encaracterizar la relación virus-hospedero, y en el caso de los virus, varios ya se han descrito como inductores de la EMT. En este artículo de revisión se describenelfenómeno de la plasticidad celular y la ocurrencia detallada del proceso de EMT, los patógenos virales reportados como inductores, los mecanismos moleculares usados para ello y las vías de regulación mediante miRNAs. Por último, se discute cómo esta relación virus-hospedero puede explicar la patogénesis de la enfermedad causada por Dengue virus, favoreciendo la identificación de blancos moleculares para terapia, estrategia conocida como Antivirales dirigidos a blancos celulares o HTA (Host-targeting antivirals).
BIOLOGÍA REPRODUCTIVA DEL BOCACHICO Prochilodus magdalenae (PROCHILODONTIDAE) EN EL RÍO SAN JORGE, COLOMBIA
Authors: Doria-González María Alejandra , Espitia-Galvis Andrea Marcela , Segura-Guevara Fredys Fernando , Olaya-Nieto Charles William 
Published: February 2021

Se estudió la biología reproductiva del Bocachico, Prochilodusmagdalenae, en el río San Jorge, Colombia. La especie es un pez con proporción sexual hembra: macho de 1,2:1, diferente a lo esperado. Presenta desarrollo ovocitario sincrónico en dos grupos, un desove anual que se extiende de abril a septiembre asociado al ciclo hidrológico del río San Jorge, talla media de madurez sexual estimada en 30,2 cm LT, ovocitos grandes de 950 µm y fecundidad promedio de 109 972 ovocitos, cuya ecuación fue F =7271,6 WO0,60, r =0,93, n =14.
Predation of Brevicoryne brassicae and Aphis craccivora by Eriopis connexa depending on availability
Authors: Dos Santos Djison Silvestre , Trindade Roseane Cristina Predes , Torres Jorge Braz , De Lima Mauricio Silva , Dos Santos Lindinalva , Batista Felipe Colares 
Published: February 2021

Predator species under field conditions can face different and variable densities of prey species. This work evaluated the functional response of the neotropical lady beetle Eriopis connexa(Coleoptera: Coccinellidae) subjected to different densities of the aphids Brevicoryne brassicaeand Aphis craccivora(Hemiptera: Aphididae). Thus, predation rates were analyzed of fourth-instar larvae and one-day old adults of the lady beetle preying upon the aphids at constant densities of 20, 40, 50, 60, and 70 aphids with 15 repetitions per density. The aphids were offered on 5 cm leaf discs of each plant host. The handling times and attack rates were 0.03 h-1and 0.27 h-1for larvae and 0.03 h-1and 0.15 h-1for adults fed B. brassicae and 0.59 h-1and 0.35 h-1for larvae and 0.70 h-1and 0.95 h-1for adults fed A. craccivora, respectively. Both larva and adult lady beetles increasedpredation rate as a function of prey density offered, with an estimated maximum number of prey consumed of 30.3 and 31.6 B. brassicae and 36.3 and 34.6 of A. craccivora by larva and adult lady beetles at the highest prey density, respectively. In conclusion, larvae and adults of E. connexaexhibited a type II functional response.
AISLAMIENTO E IDENTIFICACIÓN DE Lactobacillus spp. (LACTOBACILLACEAE) RESISTENTES A Cd(II) Y As(III) RECUPERADOS DE FERMENTO DE CACAO
Authors: Rodríguez-López Claudia Milena , Guzmán-Beltrán Ana María , Lara-Morales María Camila , Castillo Elianna , Brandão Pedro F. B. 
Published: February 2021

El objetivo de este estudio fue aislar e identificar a partir de cacao fermentado en Caldas Colombia, bacterias con potencial de aplicación en procesos biotecnológicos, como la detoxificación de cadmio (Cd(II)) y arsénico (As(III)) en el organismo humano. En total se recuperaron 36 aislados de los cuales se recuperaron 11 en presencia de 1,0 mg/L de Cd(II) y 25 en presencia de 0,1 mg/L de As(III). Su identificación molecular determinó que la mayoría de los aislados son del género Lactobacillus. Los ensayos de crecimiento en presencia de diferentes concentraciones de los elementos evaluados permitió determinar que gran parte de los aislamientos presentan resistencia a mayores concentraciones de As(III) (300 mg/L) que de Cd(II) (10 mg/L). En ensayos de tolerancia a la acidez (pH 2,5) se encontró que la cepa tipo Lactobacillus plantarumJCM 1055, junto con los aislamientos nativos L. plantarumA19, A26 y C16, mostraron la mayor tolerancia, por lo que se seleccionaron para evaluar su tolerancia a condiciones de salinidad. Las bacterias evaluadas mostraron crecimiento en concentraciones de hasta 4 g/L de sales biliares. Se concluye que los L. plantarumevaluados en este trabajo tienen un gran potencial para futuros ensayos en los que se busque demostrar la disminución de la bioaccesibilidad de Cd(II) y As(III) en condiciones in vitro del sistema digestivo humano debido a su resistencia a altas concentraciones de estos elementos y su tolerancia a condiciones de acidez y salinidad. Esto, junto con el reconocido potencial probiótico que tienen estos microorganismos, permitirá a futuro su uso en procesos biológicos de mitigación de Cd(II) y As(III).
COMPOSICIÓN MICOQUÍMICA Y ACTIVIDAD ANTIOXIDANTE DE LA SETA Pleurotus ostreatus EN DIFERENTES ESTADOS DE CRECIMIENTO
Authors: Beltrán Delgado Yaixa , Morris Quevedo Humberto Joaquin , Oliva Dominguez Daliannis , Batista Corbal Pedro , Llaurado Maury Gabriel 
Published: February 2021

Pleurotussp. es un género de basidiomicetos ampliamente distribuido a nivel mundial, con especies que revisten importancia, no solo desde el punto de vista comercial por su valor nutricional, sino también por sus propiedades medicinales. Sin embargo, aún son insuficientes los estudios micoquímicos y se desconoce su relación con las propiedades antioxidantes de bioproductos obtenidos de estas setas durante diferentes estados de crecimiento. En el presente trabajo, se determinó el contenido de proteínas, carbohidratos, azúcares reductores, fenoles totales y flavonoides, así como la actividad antioxidante in vitro(ensayos de captación de radicales DPPH y estimación del poder reductor) de extractos acuosos de Pleurotus ostreatusen dos estados de crecimiento (primordios y cuerpos fructíferos maduros) durante la fermentación sólida. El contenido de proteínas, azúcares reductores y flavonoides fue superior en el extracto acuoso de cuerpos fructíferos maduros, mientras que los carbohidratos y fenoles totales fueron mayores en el extracto de primordios. Los valores de EC50en los ensayos de DPPH y los de poder reductor fueron de 1,72 mg/mL y 3,27 mg/mL para el extracto de primordios y de 0,44 mg/mL y 0,48 mg/mL para el de cuerpos fructíferos maduros, respectivamente. Los resultados sugieren que las propiedades antioxidantes de extractos acuosos de Pleurotus ostreatus(primordios y cuerpos fructíferos maduros) reflejan las variaciones en la concentración de moléculas bioactivas, teniendo en cuenta las particularidades fisiológicas de las fases de crecimiento. Ello podría resultar de utilidad para el diseño de protocolos de obtención de bioproductos de Pleurotus ostreatuscon aplicaciones potenciales como antioxidantes en las industrias alimentaria y farmacéutica.
BIOACTIVITY OF EXTRACTS FROM SOLANACEAE AGAINST Zabrotes subfasciatus
Authors: Gonçalves Gabriel Luiz Padoan , De Lira Simone Possedente , Gissi Danilo Soares , Vendramim José Djair 
Published: February 2021

The botanical family Solanaceae has many species producing compounds with insecticidal properties, e.g. nicotine and capsaicin, which are used for pest management in agriculture. This fact provides perspectives to identify insecticidal compounds in Brazilian native species of Solanaceae. In this study, we performed a screening with 25 ethanolic extracts from 17 Solanaceae species in order to evaluate their bioactivity against the Mexican bean weevil, Zabrotes subfasciatus(Coleoptera: Chrysomelidae: Bruchinae). The bioactivity of Solanaceae ethanolic extracts (2500 mg kg-1) was tested with residual contact bioassays. Adults ofZ. subfasciatus were exposed to treated bean grains, and adult mortality, oviposition, F1progeny and damages on grains were quantified. Most of the ethanolic extracts from Solanaceae reduced the number of eggs per sample, the egg-adult viability, the F1progeny and the damages on bean grains promoted byZ. subfasciatus, but none of them interfered on its sex ratio. Ethanolic extract from leaves of Solanum lycocarpumA. St.-Hil promoted the most promissory effects on Z. subfasciatus. This ethanolic extracts can be a suitable alternative to control Z. subfasciatus in stored beans, mainly for small farmers and organic farmers.
High-Intensity Assignments for the 22 February 2011 Mw 6.2 Christchurch, Canterbury, New Zealand, Earthquake: A Contribution toward Understanding the Severe Damage Caused by This Event
Authors: Goded Tatiana , Gerstenberger Matt , Stirling Mark , Cousins Jim , Canessa Silvia 
Published: February 2021

ABSTRACT
This article presents modified Mercalli intensity (MMI) data for the 22 February 2011 Mw 6.2 Christchurch, New Zealand, earthquake. These data include intensity levels above MMI 8 that have not been assigned previously. Two sources of data have been used in this research: GeoNet’s “Felt Classic” online questionnaires and felt reports gathered during a field study in Christchurch in February 2013. Taken together, these sets of data provided 331 valid (i.e., with all the needed information) felt reports in areas of MMI 8 or above, with 299 (90%) of the reports used to assign MMI levels above 8.
This article presents a more detailed picture of the geographical damage distribution of this earthquake than has previously been available. The data differentiate damage in the center of Christchurch, with 8 communities assigned a community MMI (CMMI) of 9, 11 communities a CMMI of 10, and 8 communities a CMMI of 11, which is the maximum possible intensity in the New Zealand MMI scale, and a level of intensity not previously reported in New Zealand (Dowrick et al., 2008).
The geographical damage distribution for Christchurch has been updated for intensities below MMI 8. This was done using a recently developed method that groups intensity data and allows intensities to be aggregated for a community and a single value assigned. Comparisons between MMI and peak ground velocity using the CMMI data and two ground-motion intensity correlation equations (GMICEs) indicate an underestimation of MMI when using the GMICEs and the need to review New Zealand’s GMICE.
An Optimum 2D Seismic-Wavefield Reconstruction in Densely and Nonuniformly Distributed Stations: The Metropolitan Seismic Observation Network in Japan
Authors: Shiina Takahiro , Maeda Takuto , Kano Masayuki , Kato Aitaro , Hirata Naoshi 
Published: February 2021

Abstract
We propose an optimization method for applying the seismic-wave gradiometry (SWG) method to a dense seismic station network consisting of nonuniformly distributed seismographs. As a nonuniformly distributed station array, we consider the station layout of the Metropolitan Seismic Observation Network (MeSO-net) operated in and around the Tokyo metropolitan area, Japan. In this study, thereby, we numerically investigate optimum shapes of weighting functions, which control the spatial weights of individual stations when estimating waveforms at any grid points in the SWG method, to reconstruct seismic wavefields propagating in the MeSO-net. The functions with isotropic spatial weights are found to be appropriate for wavefield reconstructions with seismic waves incoming from practically all directions, even for nonuniformly distributed stations. The reproducibility of the wavefields is greatly improved by changing the shapes of the spatial weights reflecting density of the stations. Further plausible wavefield reconstructions are made by considering the propagation directions of the seismic waves. In these cases, if the weight of a contribution for a wavefield reconstruction is larger at far stations with a direction perpendicular to the wave propagation direction, then the reproducibility of the waveforms is significantly increased. In addition, the spatial gradients of the amplitudes are well reproduced by the optimized SWG method even though the optimization only focused on the amplitudes. Therefore, our proposed optimization scheme can be used to accurately estimate seismic wavefields in a nonuniformly distributed station array. Actually, the weighting functions optimized in this study succeeded to reconstruct the seismic wavefield of a shallow crustal earthquake that occurred around the Tokyo metropolitan area, based on the observed seismograms obtained by the MeSO-net.