bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Architecture for Handling Manufacturing Exceptions Based on Information Integration
Authors: Wang Ching-Yang , Fulton Robert E. 
Published: March 2021

Abstract
Currently, most efforts to characterize manufacturing processes are based on the normal process assumption and pay little attention to exceptions. An exception is either a rare or an unexpected event which interrupts the normal manufacturing processes. There are potential exceptions in all stages of manufacturing processes. Exceptions like resource mismanagement (at the management decisions level), process out-of-control (at the technical strategies level) and product quality deterioration (at the operational plans level) can and do occur. These exceptions can have detrimental effects on quality, reliability and productivity. Little is known about managing unexpected events in manufacturing information integration.
A conceptual exception model for handling manufacturing exceptions is proposed. The architecture of the exception model includes the views of levels impacted, process flow, inference network and decision propagation, information relations, math/logic formalism, feedback control, user action and avoidance knowledge base. These multiple views are designed to aid in understanding the exceptional problems, in characterizing the information requirements and in building an information system.
An information system for an optical fiber manufacturing process was implemented as a case study of the model. The case study has been implemented in the Smalltalk environment. The developing procedure of the information system serves to illustrate the concepts of the exception model. This research is expected to benefit persons, such as system integrators, who need to build exception management information systems. Such an information system provides a platform for users to execute exception management capabilities such as recovery plans to aid in coping with exceptions and the impact and decision propagation regarding exceptions.
Integrating Human Knowledge Into the Product Development Process
Authors: Tegel Oliver 
Published: March 2021

Abstract
Specialists are often needed for solving the demanding tasks that arise during the development of today’s advanced products. During product development, assistance is required from other departments such as manufacturing, operations scheduling etc. Even the vendors and customers should be integrated into the product development process to guarantee the product developed will be accepted in the market. Information from different people in different forms must be collected aiming at a final good design. A problem occuring during product development is, how to know which people to contact for what kind of information. An approach for solving this problem is presented in this paper.
Progression of myopia in children and teenagers: a nationwide longitudinal study
Authors: Tricard Dorian , Marillet Simon , Ingrand Pierre , Bullimore Mark A , Bourne Rupert R A , Leveziel Nicolas 
Published: March 2021

BackgroundData on myopia prevalence and progression in European children are sparse. The aim of this work was to evaluate the progression of myopia in children and teenagers in a large prospective study.MethodsA prospective study involving a nationwide cohort. Myopia was defined as a spherical equivalent (SE) of ≤ –0.50 diopters (D). Data on refractive error, gender and age were collected in 696 optical centres in France between 2013 and 2019, including 136 333 children (4–17 years old) in the analysis.Progression of myopia was assessed between the first visit and the last visit over up to 6.5 years.ResultsMean age was 11.3±3.8 years (55.0% of female). The proportion of children progressing more than –0.50 D per year was higher in age groups 7–9 years and 10–12 years and in children with SE ≤ –4.00 D at first visit, representing 33.1%, 29.4% and 30.0% of these groups, respectively. In multivariate analysis, progression during the first 11–24 months was higher in the 7–9 and 10–12 age groups (–0.43 D and –0.42 D, respectively), for higher SE at baseline (at least –0.33 D for SE ≤ –1 D) and for girls (–0.35 D).ConclusionThis is the first French epidemiological study to investigate myopia progression in a large-scale cohort of children. Sex, age groups and myopia severity are associated with differing rates of progression.
NOTCH3 variants are more common than expected in the general population and associated with stroke and vascular dementia: an analysis of 200 000 participants
Authors: Cho Bernard P H , Nannoni Stefania , Harshfield Eric L , Tozer Daniel , Gräf Stefan , Bell Steven , Markus Hugh S 
Published: March 2021

BackgroundCysteine-altering NOTCH3 variants identical to those causing the rare monogenic form of stroke, CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy), have been reported more common than expected in the general population, but their clinical significance and contribution to stroke and dementia risk in the community remain unclear.MethodsCysteine-altering NOTCH3 variants were identified in UK Biobank whole-exome sequencing data (N=200 632). Frequency of stroke, vascular dementia and other clinical features of CADASIL, and MRI white matter hyperintensity volume were compared between variant carriers and non-carriers. MRIs from those with variants were visually rated, each matched with three controls.ResultsOf 200 632 participants with exome sequencing data available, 443 (~1 in 450) carried 67 different cysteine-altering NOTCH3 variants. After adjustment for various covariates, NOTCH3 variant carriers had increased risk of stroke (OR: 2.33, p=0.0004) and vascular dementia (OR: 5.00, p=0.007), and increased white matter hyperintensity volume (standardised difference: 0.52, p<0.001) and white matter ultrastructural damage on diffusion MRI (standardised difference: 0.72, p<0.001). On visual analysis of MRIs from 47 carriers and 148 matched controls, variants were associated with presence of lacunes (OR: 5.97, p<0.001) and cerebral microbleeds (OR: 4.38, p<0.001). White matter hyperintensity prevalence was most increased in the anterior temporal lobes (OR: 7.65, p<0.001) and external capsule (OR: 13.32, p<0.001).ConclusionsCysteine-changing NOTCH3 variants are more common in the general population than expected from CADASIL prevalence and are risk factors for apparently ‘sporadic’ stroke and vascular dementia. They are associated with MRI changes of small vessel disease, in a distribution similar to that seen in CADASIL.
Trends and outcomes of ruptured ovarian cysts
Authors: Lim Wei How , Woods Nikki , Lamaro Vincent P 
Published: March 2021

AbstractBackgroundRuptured ovarian cysts are common gynaecological presentation to health institutions with abdominal pain. While this phenomenon is generally self-limiting, surgery may be necessary in cases of haemodynamic compromise or association with torsion. The aim of this audit is to identify the trend of hospital presentations, as well as the review the management of modern gynaecology practice.MethodsA retrospective audit of all women who presented to the emergency department with an imaging diagnosis of ruptured ovarian cysts was conducted over a 5-year period at St Vincent's Hospital, Sydney.ResultsDuring the study period, 408 women were identified. There was a trend towards conservative management, as observed in 84.7% of women, while the remaining 15.4% underwent surgery. Haemorrhagic or ruptured corpus luteum was the most common diagnoses. As expected, women who had surgical intervention were more likely to have larger cysts (20 vs 50%; p&lt;0.05), and larger free fluid findings on imaging (1.4 vs 23.8%; p&lt;0.05) compared with those managed conservatively. There were no statistically significant differences in location of ovarian cysts (right or left) or antecedent to hospital presentation (vaginal intercourse or trauma).ConclusionRuptured ovarian cysts of both functional and non-functional types remained a common clinical presentation of acute pain for women to the emergency department. Majority of women were managed conservatively in our cohort, and indications for surgery were large ovarian cysts and large free fluid seen on imaging findings. Surgery was largely feasible with minimal complications.
The potential environmental risks associated with the development of rare earth element production in Canada
Authors: Yin Xiangbo , Martineau Christine , Demers Isabelle , Basiliko Nathan , Fenton Nicole J. 
Published: March 2021

The development of rare earth element (REE) production in Canada could generate significant economic benefits but also poses serious potential risks to the environment. Rare earth elements have been widely used in modern life and industries and are even indispensable in some crucial advanced technologies (e.g., permanent magnets). Increasing demand and the current United States – China trade tensions provide a commercial economic development opportunity for Canada, which has rich resources of REEs, to develop its own sector. However, environmental and health issues caused by REE production are challenges that Canada has to face given that significant environmental impacts have been reported elsewhere (e.g., China). Little literature is available on the potential environmental risks associated with the development of REE production in Canada. It is important to know what environmental issues, particularly those generated by REEs themselves, may happen in Canada in the future. Therefore, three major aspects are evaluated and summarized from multidisciplinary perspectives in this paper: (1) a general conceptual model of the transport of REEs as a group in the environment is established; (2) toxicity levels, biochemical mechanisms, and physiological effects of REEs on different organisms are reviewed, and case-studies from existing REE mining areas are briefly highlighted; and (3) considering specific environmental condition and risk factors, environmental risks that Canada may face in future REE developments are identified and discussed. This review concludes with macro-identification of potential environmental risks associated with the development of REE production in Canada considering both human and ecological health. We note that ingestion, inhalation, and dermal exposure for workers and surrounding residents (including potentially Indigenous communities) and subarctic and arctic climate conditions could increase the risks to human and ecological health in future REE production development in Canada. Finally, future research directions are proposed that could be applied to both Canadian and other geographical contexts.
South-Central Barents Sea Composite Tectono-Sedimentary Element
Authors: Doré A. G. , Dahlgren T. , Flowerdew M. J. , Forthun T. , Hansen J. O. , Henriksen L. B. , Kåsli K. , Rafaelsen B. , Ryseth A. E. , Rønning K. , Similox-Tohon D. , Stoupakova A. , Thießen O. 
Published: March 2021

Abstract
The south-central Barents Sea today comprises a shallow continental shelf with water depths mainly in the 200–400 m range, straddling the Norway–Russia marine boundary. Geologically, it consists of a stable platform (the Bjarmeland Platform) dissected by rifts of probable Late Carboniferous age, with a significant and geologically persistent basement high (the Fedynsky High) in its southeastern part. The rifts are the ENE–WSW-trending Nordkapp Basin, the similarly trending but less clearly demarcated Ottar Basin and the NW–SE Tiddlybanken Basin. The varying rift trends appear to reflect the orogenic grain patchwork of the basement (Caledonide and Timanide), and these basins were infilled with a variable facies assemblage including substantial Carboniferous–Permian halites.
A massive sedimentary influx of fluvio-deltaic to shallow-marine sediments took place in the Triassic, from the east and SE (Urals, Novaya Zemlya and western Siberia) and the south (Baltic Shield), resulting in doming and diapirism in the areas of thickest salt, particularly in the rifts. The succeeding Jurassic, Cretaceous and Cenozoic successions are generally thin, locally thickening in rim synclines and in the NE of the area towards the deep basins flanking Novaya Zemlya. Reactivation of the halokinetic structures took place in the early Cenozoic, probably associated with the development of the NE Atlantic–Arctic Ocean linkage.
Marine source rocks of Triassic and Late Jurassic age are present in the area, along with Carboniferous and Permian source rocks of uncertain effectiveness. Petroleum has been found in Jurassic and Triassic clastic reservoirs, including recent shallow Jurassic oil and gas discoveries. Although none is currently in production, near-future oil development is likely in the Wisting discovery, on the western margin of the area. New exploration, including drilling, has taken place in the east of the area as a result of recent Norwegian and Russian licensing.
Renal Sympathetic Denervation in Patients With Heart Failure With Preserved Ejection Fraction
Authors: Kresoja Karl-Patrik , Rommel Karl-Philipp , Fengler Karl , von Roeder Maximilian , Besler Christian , Lücke Christian , Gutberlet Matthias , Desch Steffen , Thiele Holger , Böhm Michael , Lurz Philipp 
Published: March 2021

Background:
Arterial hypertension is the most common comorbidity in patients with heart failure with preserved ejection fraction (HFpEF) and mediates adverse hemodynamics through related aortic stiffness and increased pulsatile load. We aimed to investigate the clinical and hemodynamic implications of renal sympathetic denervation (RDN) in patients with HFpEF and uncontrolled arterial hypertension.

Methods:
Patients undergoing RDN between 2011 and 2018 in a single-center were retrospectively analyzed and classified as HFpEF (n=99) or no HF (n=65). Stroke volume index and aortic distensibility were measured through cardiac magnetic resonance imaging, and left ventricular (LV) systolic and diastolic properties were assessed echocardiographically.

Results:

At baseline, patients with HFpEF had higher stroke volume index (median 40 [interquartile range, 33–48] versus 33 [26–40] mL/m
2
,
P
=0.002), pulse pressure (69 [63–77] versus 61 [55–67] mm Hg,
P
<0.001), but lower LV-VPES
100mm Hg
(18 [10–28] versus 24 [15–40] mL,
P
=0.007) and aortic distensibility (1.5 [1.1–2.6] versus 2.7 [1.1–3.5] 10
−3
mm Hg
−1
,
P
=0.013) as compared to no-HF patients. Systolic blood pressure decreased comparable in patients with HFpEF and no-HF patients following RDN (−9 [−16 to −2],
P
<0.001). After RDN stroke volume index (−3 [−9 to +3] mL/m
2
,
P
=0.011) decreased and aortic distensibility (0.2 [−0.1 to +1.1] 10
−3
mm Hg
−1
,
P
=0.007) and systolic stiffness (
P
<0.001) increased in HFpEF patients. LV diastolic stiffness and LV filling pressures as well as NT-proBNP (N-terminal pro-B-type natriuretic peptide) decreased after RDN in patients with HFpEF (
P
=0.032,
P
=0.043, and
P
<0.001, respectively).

Conclusions:
Patients with HFpEF undergoing RDN showed increased stroke volume index, vascular, and LV stiffness as compared to no-HF patients. Following RDN those hemodynamic alterations and reduced systolic and diastolic LV stiffness were partly normalized, implying RDN might be a potential therapeutic strategy for arterial hypertension and HFpEF.
Replacement Myocardial Fibrosis in Patients With Mitral Valve Prolapse
Authors: Constant Dit Beaufils Anne-Laure , Huttin Olivier , Jobbe-Duval Antoine , Senage Thomas , Filippetti Laura , Piriou Nicolas , Cueff Caroline , Venner Clément , Mandry Damien , Sellal Jean-Marc , Le Scouarnec Solena , Capoulade Romain , Marrec Marie , Thollet Aurélie , Beaumont Marine , Hossu Gabriella , Toquet Claire , Gourraud Jean-Baptiste , Trochu Jean-Noël , Warin-Fresse Karine , Marie Pierre-Yves , Schott Jean-Jacques , Roussel Jean-Christian , Serfaty Jean-Michel , Selton-Suty Christine , Le Tourneau Thierry 
Published: March 2021

Background:
Mitral valve prolapse (MVP) is a frequent disease that can be complicated by mitral regurgitation (MR), heart failure, arterial embolism, rhythm disorders, and death. Left ventricular (LV) replacement myocardial fibrosis, a marker of maladaptive remodeling, has been described in patients with MVP, but the implications of this finding remain scarcely explored. We aimed at assessing the prevalence, pathophysiological and prognostic significance of LV replacement myocardial fibrosis through late gadolinium enhancement (LGE) by cardiac magnetic resonance in patients with MVP.

Methods:
Four hundred patients (53±15 years of age, 55% male) with MVP (trace to severe MR by echocardiography) from 2 centers, who underwent a comprehensive echocardiography and LGE cardiac magnetic resonance, were included. Correlates of replacement myocardial fibrosis (LGE+), influence of MR degree, and ventricular arrhythmia were assessed. The primary outcome was a composite of cardiovascular events (cardiac death, heart failure, new-onset atrial fibrillation, arterial embolism, and life-threatening ventricular arrhythmia).

Results:

Replacement myocardial fibrosis (LGE+) was observed in 110 patients (28%; 91 with myocardial wall including 71 with basal inferolateral wall, 29 with papillary muscle). LGE+ prevalence was 13% in trace-mild MR, 28% in moderate MR, and 37% in severe MR, and was associated with specific features of mitral valve apparatus, more dilated LV and more frequent ventricular arrhythmias (45% versus 26%,
P
<0.0001). In trace-mild MR, despite the absence of significant volume overload, abnormal LV dilatation was observed in 16% of patients and ventricular arrhythmia in 25%. Correlates of LGE+ in multivariable analysis were LV mass (odds ratio, 1.01 [95% CI, 1.002–1.017],
P
=0.009) and moderate-severe MR (odds ratio, 2.28 [95% CI, 1.21–4.31],
P
=0.011). LGE+ was associated with worse 4-year cardiovascular event–free survival (49.6±11.7 in LGE+ versus 73.3±6.5% in LGE–,
P
<0.0001). In a stepwise multivariable Cox model, MR volume and LGE+ (hazard ratio, 2.6 [1.4–4.9],
P
=0.002) were associated with poor outcome.

Conclusions:
LV replacement myocardial fibrosis is frequent in patients with MVP; is associated with mitral valve apparatus alteration, more dilated LV, MR grade, and ventricular arrhythmia; and is independently associated with cardiovascular events. These findings suggest an MVP-related myocardial disease. Last, cardiac magnetic resonance provides additional information to echocardiography in MVP.
Extracellular Tuning of Mitochondrial Respiration Leads to Aortic Aneurysm
Authors: Oller Jorge , Gabandé-Rodríguez Enrique , Ruiz-Rodríguez María Jesús , Desdín-Micó Gabriela , Aranda Juan Francisco , Rodrigues-Diez Raquel , Ballesteros-Martínez Constanza , Blanco Eva María , Roldan-Montero Raquel , Acuña Pedro , Forteza Gil Alberto , Martín-López Carlos E. , Nistal J. Francisco , Lino Cardenas Christian L. , Lindsay Mark Evan , Martín-Ventura José Luís , Briones Ana M. , Miguel Redondo Juan , Mittelbrunn María 
Published: March 2021

Background:

Marfan syndrome (MFS) is an autosomal dominant disorder of the connective tissue caused by mutations in the
FBN1
(fibrillin-1) gene encoding a large glycoprotein in the extracellular matrix called fibrillin-1. The major complication of this connective disorder is the risk to develop thoracic aortic aneurysm. To date, no effective pharmacologic therapies have been identified for the management of thoracic aortic disease and the only options capable of preventing aneurysm rupture are endovascular repair or open surgery. Here, we have studied the role of mitochondrial dysfunction in the progression of thoracic aortic aneurysm and mitochondrial boosting strategies as a potential treatment to managing aortic aneurysms.

Methods:

Combining transcriptomics and metabolic analysis of aortas from an MFS mouse model (
Fbn1

c1039g/+

) and MFS patients, we have identified mitochondrial dysfunction alongside with mtDNA depletion as a new hallmark of aortic aneurysm disease in MFS. To demonstrate the importance of mitochondrial decline in the development of aneurysms, we generated a conditional mouse model with mitochondrial dysfunction specifically in vascular smooth muscle cells (VSMC) by conditional depleting Tfam (mitochondrial transcription factor A;
Myh11-Cre

ERT2

Tfam

flox/flox

mice). We used a mouse model of MFS to test for drugs that can revert aortic disease by enhancing Tfam levels and mitochondrial respiration.

Results:

The main canonical pathways highlighted in the transcriptomic analysis in aortas from
Fbn1

c1039g/+

mice were those related to metabolic function, such as mitochondrial dysfunction. Mitochondrial complexes, whose transcription depends on Tfam and mitochondrial DNA content, were reduced in aortas from young
Fbn1

c1039g/+

mice. In vitro experiments in
Fbn1
-silenced VSMCs presented increased lactate production and decreased oxygen consumption. Similar results were found in MFS patients. VSMCs seeded in matrices produced by Fbn1-deficient VSMCs undergo mitochondrial dysfunction. Conditional Tfam-deficient VSMC mice lose their contractile capacity, showed aortic aneurysms, and died prematurely. Restoring mitochondrial metabolism with the NAD precursor nicotinamide riboside rapidly reverses aortic aneurysm in
Fbn1

c1039g/+

mice.

Conclusions:
Mitochondrial function of VSMCs is controlled by the extracellular matrix and drives the development of aortic aneurysm in Marfan syndrome. Targeting vascular metabolism is a new available therapeutic strategy for managing aortic aneurysms associated with genetic disorders.
The Antinomies of Antonio Gramsci: A Rereading
Authors: Dal Maso Juan , Grinberg Gloria , Trevín Marisela 
Published: March 2021

Abstract
This essay discusses the main contentions of The Antinomies of Antonio Gramsci by Perry Anderson in a critical reading of both the positions of the British historian, and of his critics among ‘Togliattian Gramscianists’.
Multisourced Flood Inventories over the Contiguous United States for Actual and Natural Conditions
Authors: Huang Zhijun , Wu Huan , Adler Robert F. , Schumann Guy , Gourley Jonathan J. , Kettner Albert , Nanding Nergui 
Published: March 2021

AbstractA reliable flood event inventory that reflects the occurrence and evolution of past floods is important for studies of flood hazards and risks, hydroclimatic extremes, and future flood projections. However, currently available flood inventories are based on single-sourced data and often neglect underreported or less impactful flood events. Furthermore, traditional archives store flood events only at sparse geographic points, which significantly limits their further applicability. Also, few publicly available archives contain all-inclusive records of potential natural flooded area over time. To tackle these challenges, we construct two types of multisourced flood event inventories (MFI) for all river basins across the contiguous United States covering the period 1998–2013 on daily and subcatchment scales, which is publicly available at http://flood.umd.edu/download/CONUS/. These archives integrate flood information from in situ observations, remote sensing observations, hydrological model simulations, and five high-quality precipitation products. The first inventory (MFI-Actual) includes all actual floods that occurred in the presence of flood protection infrastructures, while the second, “natural (undefended)” inventory (MFI-Natural) reconstructs the possible “historical” floods without flood protection, which could be more directly influenced by climate variation. In the proposed two inventories, 2,755 and 4,661 flood events were estimated, respectively. MFI-Natural reconstructed 1,597 floods in ungauged basins, and recovered 608 extreme streamflow events in gauged subcatchments where floods would have happened if there were no flood protection. There is an average of four upstream dams located in these flood-recovered subcatchments, which indicates that modern flood defenses efficiently prevent significant flooding from extreme precipitation in many catchments over the country.