bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanistic studies of non-canonical amino acid mutagenesis
Authors: Fleisher Rachel C. , Michael Nina , Gonzalez Ruben L. 
Published: June 2021

AbstractOver the past decade, harnessing the cellular protein synthesis machinery to incorporate non-canonical amino acids (ncAAs) into tailor-made peptides has significantly advanced many aspects of molecular science. More recently, groundbreaking progress in our ability to engineer this machinery for improved ncAA incorporation has led to significant enhancements of this powerful tool for biology and chemistry. By revealing the molecular basis for the poor or improved incorporation of ncAAs, mechanistic studies of ncAA incorporation by the protein synthesis machinery have tremendous potential for informing and directing such engineering efforts. In this chapter, we describe a set of complementary biochemical and single-molecule fluorescence assays that we have adapted for mechanistic studies of ncAA incorporation. Collectively, these assays provide data that can guide engineering of the protein synthesis machinery to expand the range of ncAAs that can be incorporated into peptides and increase the efficiency with which they can be incorporated, thereby enabling the full potential of ncAA mutagenesis technology to be realized.
Deep learning and machine learning for EEG signal processing on the example of recognizing the disease of alcoholism
Authors: Ildar Rakhmatulin 
Published: June 2021

AbstractAlcoholism is one of the most common diseases in the world. This type of substance abuse leads to mental and physical dependence on ethanol-containing drinks. Alcoholism is accompanied by progressive degradation of the personality and damage to the internal organs. Today still not exists a quick diagnosis method to detect this disease. This article presents the method for the quick and anonymous alcoholism diagnosis by neural networks. For this method, don’t need any private information about the subject. For the implementation, we considered various algorithms of machine learning and deep neural networks. In detail analyzed the correlation of the signals from electrodes by neural networks. The wavelet transforms and the fast Fourier transform was considered. The manuscript demonstrates that the deep neural network which operates only with a dataset of EEG correlation signals can anonymously classify the alcoholic and control groups with high accuracy.On the one hand, this method will allow subjects to be tested for alcoholism without any personal data, which will not cause inconvenience or shame in the subject, and on the other hand, the subject will not be able to deceive specialists who diagnose the subject for the presence of the disease.
How do packet losses affect measures of averaged neural signals?
Authors: Dastin-van Rijn Evan M. , Harrison Matthew T. , Borton David A. 
Published: June 2021

AbstractRecent advances in implanted device development have enabled chronic streaming of neural data to external devices allowing for long timescale, naturalistic recordings. However, characteristic data losses occur during wireless transmission. Estimates for the duration of these losses are typically uncertain reducing signal quality and impeding analyses. To characterize the effect of these losses on recovery of averaged neural signals, we simulated neural time series data for a typical event-related potential (ERP) experiment. We investigated how the signal duration and the degree of timing uncertainty affected the offset of the ERP, its duration in time, its amplitude, and the ability to resolve small differences corresponding to different task conditions. Simulations showed that long timescale signals were generally robust to the effects of packet losses apart from timing offsets while short timescale signals were significantly delocalized and attenuated. These results provide clarity on the types of signals that can be resolved using these datasets and provide clarity on the restrictions imposed by data losses on typical analyses.
Radiation-reprogrammed glioma stem cells generate vascular-like cells to build a trophic niche driving tumor recurrence
Authors: Muthukrishnan Sree Deepthi , Kawaguchi Riki , Nair Pooja , Prasad Rachna , Qin Yue , Johnson Maverick , VanderVeer-Harris Nathan , Condro Michael C. , Alvarado Alvaro G. , Pham Amy , Gau Raymond , Wang Qing , Castro Maria G. , Lowenstein Pedro R. , Deb Arjun , Hinman Jason D. , Pajonk Frank , Burns Terry C. , Goldman Steven A. , Geschwind Daniel H. , Kornblum Harley I. 
Published: June 2021

AbstractTreatment-refractory glioma stem and tumor cells exhibit phenotypic plasticity driving recurrence, but the underlying molecular mechanisms remain to be elucidated. Here, we employed single-cell and whole transcriptomic analyses to discover that radiation induces a dynamic shift in functional states of glioma cells allowing for acquisition of vascular endothelial-like and pericyte-like cell phenotypes. These vascular-like cells provide a trophic niche to promote proliferation of irradiated glioma cells, and their selective depletion results in reduced tumor growth post-treatment in vivo. Mechanistically, the acquisition of vascular-like phenotype is driven by increased chromatin accessibility and H3K27 acetylation in specific vascular gene regions post-treatment. Blocking P300 histone acetyltransferase activity reverses the epigenetic changes induced by radiation, and inhibits the phenotypic transition and tumor growth. Our findings highlight an important role for P300 histone acetyltransferase in treatment-induced plasticity and opens a new therapeutic avenue for preventing glioma recurrence.SignificanceOur study demonstrates that radiation therapy promotes glioma resistance by inducing vascular-like phenotypes in GSC that, in turn, aid in proliferation of the remaining tumor cells. This phenotype switch is mediated by P300 HAT, and inhibition of this enzyme is a potential therapeutic target for preventing glioma recurrence following radiation.
Believe to go the extra mile: the influence of internal CSR initiatives on service employee organizational citizenship behaviors
Authors: Chou En-Yi , Liang Haw-Yi , Lin Jiun-Sheng Chris 
Published: June 2021

PurposeLeveraging the power of corporate social responsibility (CSR) is strategically important to corporations. Although various studies have explored the positive effects of CSR, few have been devoted to the investigation of CSR related to service employees from the internal marketing perspective. Therefore, this study fills this research gap by developing a conceptual model based on social influence theory to explain how internal CSR initiatives affect service employees' attitudes and behaviors.Design/methodology/approachThis study develops and empirically tests a theoretical model examining the impact of internal CSR initiatives (i.e. internal dissemination of and management support for CSR) on service employees' attitudes toward an organization (i.e. employee–company identification and value congruence), which ultimately enhance their organizational citizenship behaviors (OCBs) toward customers, other employees and the organization. Survey data from 271 frontline employees of service firms actively involved in CSR-related activities were examined with structural equation modeling.FindingsThe results suggest that perceived internal dissemination of and management support for CSR affect service employees' citizenship behaviors toward customers, other employees and the organization through the mediation of employee–company identification and value congruence.Practical implicationsInternal CSR initiatives are highly related to service employees' various OCBs that are beneficial to improving the service performance of firms. Therefore, it is imperative for companies to devote attention to internal marketing dissemination while promoting CSR. In addition, as managers' attitudes and behaviors trickle down to employees, service supervisors' support of CSR activities plays a significant role in forming employee perceptions of a firm's CSR dedication.Originality/valueThis study represents one of the first to view internal CSR initiatives as an effective internal marketing lever. Moreover, the relationship between internal CSR initiatives and service employees' OCBs – OCB toward customers, other employees and the organization – is proposed and tested with an empirical model, providing significant contributions.
Investigating the factors influencing Australian logistics companies toward environmental activity adoption
Authors: Sadeghian Esfahani Sonia , Cahoon Stephen , Chen Shu-Ling , Pateman Hilary , Sajadi Seyed Mojtaba 
Published: June 2021

PurposeThis paper aims to examine 12 factors influencing environmental activity adoption by Australian logistics companies.Design/methodology/approachAfter a literature review and collect the major factors influencing environmental activity adoption, exploratory factor analysis (EFA) and Friedman test are used to cluster and prioritize these factors through a Web survey.FindingsThe results of EFA show that these factors belong to three main groups including social and economic, pressure and governmental factors. The results of a Friedman test prioritizes 12 factors to find which factors have the greatest importance toward the adoption of environmental activity by managers of Australian logistics companies and reveals that governmental regulation, fuel and energy prices and the potential for achieving a competitive advantage, had the first to third ranking, respectively. Some new influencing factors in implementing environmental activities are found such as the willingness to be the market leader, responsibility and risk mitigation.Research limitations/implicationsThis paper contributes to the literature by exploring the new factors influencing environmental adoption.Practical implicationsAustralian logistics managers can use the results of this paper in developing their strategies and public policymakers can also use these results to improve sustainable development.Originality/valueThis is the first paper that clusters and prioritizes factors influencing environmental adoption in the Australian logistics industry.
The impact of time budget and time deadline pressures on audit behaviour: UK evidence
Authors: Nehme Rabih , Michael Amir , Haslam Jim 
Published: June 2021

Purpose
A survey is here systematically conducted to analyse auditors’ perceptions of dysfunctional auditing behaviour (DAB). As a result of many accounting scandals and litigations faced by audit firms, this paper aims to assess whether factors leading to DAB are embedded in audit firms’ practices.

Design/methodology/approach
The sample used in this study comprises auditors at all levels of employment with the big four audit firms in the United Kingdom (UK). DAB is analysed using two signals/indicators: premature sign-off and under-reporting of chargeable time. Time budget pressure and time deadline pressure are the factors considered here as potentially pushing auditors to exhibit DAB. A careful and considered analysis and interpretation is here articulated. Additionally, the sample individuals are divided into audit trainees and experienced auditors to assess any potential differences in the perception of DAB that reflect the experience factor.

Findings
Coordination with internal auditors, different perceptions between audit trainees and experienced auditors of dysfunctional behaviour, working during their personal time and the box-ticking exercise are amongst the findings that may help practitioners to understand the reasons behind dysfunctional behaviour and identify measures to mitigate it.

Originality/value
The study can aid concerned executives and audit partners to minimise DAB related to different time pressures by casting light on the key ethical issues. The study is conducted on a sample of the big four firms in the UK covering all organisational structure. It assesses if experience plays a role in the perception of DAB.
Insights from a survey “comments” section: extending research on doctoral well-being
Authors: Sverdlik Anna , Mcalpine Lynn , Hall Nathan 
Published: June 2021

Purpose
The purpose of this study is to better understand the declines in doctoral students’ mental and physical health while pursuing their doctoral degrees, by revealing the major themes of students’ voluntary comments following a survey that primed students to reflect on these topics.

Design/methodology/approach
The present study used qualitative thematic analysis to uncover themes in doctoral students’ voluntary comments on a large-scale, web-based survey of graduate students’ motivation and well-being.

Findings
A thematic analysis revealed six major emerging themes: timing in the degree process, work-life balance, health/well-being changes, impostor syndrome, the supervisor and hopelessness.

Research limitations/implications
The themes uncovered in the present study contribute to the literature by highlighting important underexplored topics (e.g. timing in the degree process, hopelessness) in doctoral education research and they are discussed and situated in the context of existing literature.

Practical implications
Implications for doctoral supervisors and departments are discussed.

Social implications
The present study highlights some pressing concerns among doctoral students, as articulated by the students themselves and can contribute to the betterment of doctoral education, thereby reducing attrition, improving the experiences of doctoral students and possibly affording more candidates to achieve a doctoral degree.

Originality/value
The present study makes the above-mentioned contributions by taking a novel approach and analyzing doctoral students’ voluntary comments (n = 607) on a large-scale, web-based survey. Thus, while some of the themes were primed by the survey itself, the data represent issues/concerns that students perceived as important enough to comment about after already having completed a lengthy questionnaire.
Towards sustainable tourism development: an evaluation of the current state of energy efficiency in North Cyprus
Authors: Özgit Hale , Abbasoğlu Serkan 
Published: June 2021

Purpose
This paper aims to review the current state of energy efficiency in North Cyprus and the extent to which this supports small island sustainable tourism development, together with related policy implications.

Design/methodology/approach
Documentary analysis is used to evaluate energy efficiency studies in North Cyprus.

Findings
Results of this study reveal that the legal framework relating to energy efficiency and stakeholder reports about the level of energy efficiency falls short of expectations for sustainable tourism practices from an energy efficiency perspective.

Practical implications
Policymakers should consider revising the current draft energy efficiency law to take into account the needs and views of hospitality and tourism stakeholders. This could be accomplished by involving them in discussions about how enhanced energy efficiency could contribute to economic, social and environmental development. Further, policymakers and these industry stakeholders in North Cyprus should develop common goals to harmonise tourism and energy regulations in support of sustainable development.

Originality/value
This study evaluates current energy efficiency developments and possible contributions to sustainable tourism development in North Cyprus. Energy efficiency policy has not yet been applied in North Cyprus, and a broad-ranging policy could help to prevent future environmental problems in North Cyprus.
Benchmarking government: Report on government services (RoGS) – 25 years on
Authors: McGuire Linda , Prior Jonson Elizabeth , Perryman Steve , McKeown Tui 
Published: June 2021

AbstractRobust indicators and measures for outputs and outcomes against agreed objectives are the holy grail of performance reporting. Transparent performance reporting can be a means to improving accountability to taxpayers for public funds and responsiveness to users. The Report on Government Services (RoGS) for the Council of Australian Governments (COAG) is widely seen as ‘an exemplar of benchmarking in a federal system.’ Twenty‐five years on, RoGS has been institutionalised and the approach to performance reporting was central to the COAG reform agenda. Annual reports compare the equity, effectiveness, and efficiency of outputs and outcomes across governments in six key areas – childcare, education and training; health; justice; emergency management; community services; and housing and homelessness. Performance indicators and measures have increased the accountability of state and territory governments for their management of public funds. The significance of RoGS is the unprecedented scale and scope of performance indicators and its longevity. The services benchmarked in the 25th report in 2020 accounted for $247 billion, representing 70% of government recurrent expenditure and 13% of GDP.
Do Business Angels’ Investments Make It Easier to Raise Follow‐on Venture Capital Financing? An Analysis of the Relevance of Business Angels’ Investment Practices
Authors: Capizzi Vincenzo , Croce Annalisa , Tenca Francesca 
Published: June 2021

AbstractIn this paper, we shed light on interactions among the various investors operating within the entrepreneurial finance ecosystem. Specifically, we aim to investigate what business angel (BA) investment practices are correlated with follow‐on venture capital (VC) financing, and uncover the strategies that determine a complementary‐based or a substitution‐based relationship with VCs. We analysed a sample of 176 companies that received a BA investment during 2008–2016 and collected financial data over a 10‐year period after the BA investment. The data examined indicate that BAs’ selectivity, as measured by their rejection rate, and BAs’ affiliation to an angel network, are positively related with the probability of raising follow‐on VC financing. However, a high level of BAs’ monitoring activity negatively influences the probability of obtaining VC funding. Interestingly, BA networks do affect this relationship. The positive impact of BAs’ rejection rate is informative for VC decisions if the BA does not invest through a network. Conversely, a high level of monitoring may convey a negative signal for VC, particularly if the BA is affiliated to a network. These results extend our knowledge of the investment practices of BAs and their role in allowing angel‐backed companies to raise follow‐on VC financing.
New Trajectories in Worker Voice: Integrating and Applying Contemporary Challenges in the Organization of Work
Authors: Wilkinson Adrian , Knoll Michael , Mowbray Paula K. , Dundon Tony 
Published: June 2021

AbstractThis paper aims to encourage a debate on the proposed transactive relationship between voice and contemporary social, economic and technological (SET) developments. Specifically, we propose that SET developments change how work is approached, organized and designed, and that these changes challenge employee rights, roles and responsibilities. How employees deal with these challenges affects their well‐being and health, and whether organizations and societies can develop sustainably. While voice is a way for employees to have a say in these developments, we argue that SET changes can be times at which voice is threatened. Moreover, we propose that SET changes urge us to question and reshape our understanding of voice. We propose that a functional conceptualization of voice provides opportunities to integrate existing approaches which are often scattered across disciplines, and is inclusive of new opportunities and constraints that come with SET developments. Using examples of two meta‐trends, we illustrate how SET changes challenge traditional conceptualizations of voice and identify ‘new trajectories’ to expand more inclusive forms of voice and more useful research paradigms. These meta‐trends are digitalization (including new business models and employment forms, alternative/flexible work arrangements, technology‐mediated communication) and diversification (including internationalization and marginalized/minority groups).
Rethinking Universal Health Coverage: A qualitative study of patient organisation perspectives on the Turkish health‐care system
Authors: Yilmaz Volkan 
Published: June 2021

AbstractUniversal health coverage (UHC) has been elevated to the status of a global policy target, but this was at the expense of losing its aspirational meaning. As a case in point, Turkey has been one of the countries that has achieved UHC, according to the technocratic definition. This article employs a combination of deductive and inductive thematic analysis methods to explore patient organisation (PO) perspectives on the Turkish health‐care system based on 26 respondent interviews from 19 POs in Istanbul. Highlighting the inadequacy of the technocratic definition of UHC, the article maintains that an analysis of PO perspectives opens the way for a nuanced and bottom‐up assessment of essential service coverage and financial protection by identifying elusive gaps in both dimensions that would otherwise be lost in generalist evaluations. The findings also underline the importance of keeping intact the UHC’s aspirational element to enable POs to participate in the politics of priority setting in health care.
Body mass index is just a number: Conflating riskiness and unhealthiness in discourse on body size
Authors: Gutin Iliya 
Published: June 2021

AbstractDespite the ubiquity of the body mass index (BMI) in discourse on health, there is ambiguity in its use as a biomarker of current abnormality versus future risk. This distinction is consequential for knowledge of the relationship between body size and health, as well as for individuals deemed to have abnormal and ‘unhealthy’ bodies. Consequently, the purposes of this review are threefold. The first is to differentiate this ‘biomarker’ perspective from extant critiques of BMI as a proxy for healthbehavioursor as the defining characteristic of obesity as adisease. The second is to highlight the shift towards treating BMI as a measure of attained unhealthiness, rather than a probabilistic indicator of risk. Finally, rather than call for the abolition of BMI, this paper argues that its continued use as ‘just a number’ is in keeping with the push for weight neutrality in research and practice. The review concludes by demonstrating how the riskiness and unhealthiness of body size is conflated in public health messaging on COVID‐19. BMI is a marker of risk, but its use as a surrogate for COVID‐19 severity equates body size with health, shaping beliefs about vulnerability and personal responsibility amid an ongoing pandemic.
Financial conditions, local competition, and local market leaders: The case of real estate developers
Authors: Fan Ying , Leung Charles Ka Yui , Yang Zan 
Published: June 2021

AbstractThis paper studies whether (and how) corporate decisions are affected by internal factors (e.g., the financial conditions of own company) and external factors (e.g., the actions of local competitors) in an imperfectly competitive environment. We study the listed real estate developers in Beijing as a case study. Our hand‐collected dataset includes transaction‐level information booked indicators (e.g., profitability, liability, and liquidity) and unbooked financial indicators (political connections). Our multi‐step empirical model shows that both the firm's financial conditions and its competitors' counterparts are essential but play different roles in the output design, pricing, and the time‐on‐the‐market (TOM). Internal versus external factors' relative importance relates nonlinearly to the degrees of market concentration. Market leaders' existence alters the small firms' strategy and leads to higher selling prices and slower selling pace in the local market. Our comprehensive financial indicators (booked and unbooked) better predict corporate behaviors than traditional measures.