bluuebunny/crossref_metadata_2025_split huggingface dataset:
Basal ganglia and cerebellar lesions causally impact the neural encoding of temporal regularities
Authors: Criscuolo Antonio , Schwartze Michael , Nozaradan Sylvie , Kotz Sonja A. 
Published: February 2025

Abstract
Acting in and adapting to a dynamically changing environment necessitates to precisely encode the timing of sensory events, and to time our own (re-)actions to them. Cerebellar (CE) and basal ganglia (BG) circuitries play fundamental and complementary roles in timing processes. While the CE seems to use precise timing (when an event occurs) and temporal intervals to generate temporal predictions (when a next event occurs), the BG uses relative timing to extract the beat in rhythmic sequences. As it is generally difficult to record data from respective patient groups in parallel, CE and BG contributions to timing processes are rarely investigated in combination. Here, we let healthy controls and patients with CE or BG lesions listen to isochronous auditory sequences while their EEG was recorded. We assessed intra- and inter-individual variabilities, as well as group differences, using event-related potentials (ERP), delta-band inter-trial phase-coherence, and acceleration dynamics while tuning to the stimulation frequency (Sf). CE and BG lesions increased variability in ERP latency and reduced the coherence of delta-band activity. CE but not BG lesions further impacted the stability of delta-band oscillations while tuning to the Sf. These findings show a causal link between subcortical lesions and the capacity to encode and synchronize ongoing neural activity with temporal regularities in the acoustic environment. While most standard metrics of neural entrainment do not dissociate specific contributions of BG and CE to sound processing in isochronous sequences, the newly introduced ‘stability’ metric isolated distinct changes in delta-band tuning dynamics in CE patients. This observation highlights the fundamental role of the CE in generating and maintaining stable neural representations of event onsets in the sensory environment.
Predicting nasal diseases based on microbiota relationship network
Authors: Liang Yibo , Mao Jie , Qiu Tianlei , Li Binghua , Zhang Chenting , Zhang Kai , Sun Zhe , Zhang Guimin 
Published: February 2025

Objectives Increasing evidence indicates that the local microbiome can be used to predict host disease states. However, constructing models that obtain better results with fewer features is still challenging. Methods In this study, we established a nasal microbiome database consisting of 132 chronic rhinosinusitis patients, 27 nasal inverted papilloma patients, and 45 control patients. 16S rRNA gene sequencing was used to identify the species and abundance of bacteria in each sample, and a nasal microbiome database was generated after low-abundance bacteria were eliminated. The correlation data network of different groups of bacteria was constructed by calculating the correlation coefficient among bacterial genera, and the correlation parameters of the network were calculated based on graph theory. Through the development and application of a machine learning framework to optimize the screening process, combined with microbiome relationship network parameters based on graph theory, basic bacteria with high contributions to classification prediction were selected for the prediction of nasal diseases. Results We found that patients with nasal disease have a specific nasal microbiome signature and identified Moraxella, Prevotella, and Rothia as keystone genera that are markers of nasal disease; these markers can be interpreted as key control routes through graph theory analysis of the microbiota. With this strategy, we were able to characterize microbial community changes in nasal disease patients, which could reveal the potential role of the nasal microbiome in nasal disease. Conclusion This study can provide a reference for the formulation of disease prevention and control policies. Our framework can be applied to other diseases to identify keystone genera that influence disease states and can be used to predict disease states.
CT radiomics for evaluation of intervertebral disc change in the scoliosis
Authors: Fang Yuqi , He Yun 
Published: February 2025

Background Advanced methods are still lacking for the computed tomography (CT) evaluation of early degenerative changes of intervertebral disc in scoliosis. Purpose To investigate the feasibility of CT radiomics in evaluating early disc degeneration changes in scoliosis. Material and Methods A total of 60 patients with severe scoliosis were assessed with the method of CT radiomics. CT radiomics features of the intervertebral disc were obtained by using the software of 3D Slicer and were then compared between vertex disc (VD) and normal disc (ND). The analysis of maximum correlation minimum redundancy (mRMR) and the least absolute shrinkage and selection operator (LASSO) regression method was used to establish a model. The receiver operating characteristic (ROC) curve was used to determine the performance of the model. Results ND and VD differed in 23 radiomics features ( P < 0.05). By using mRMR and LASSO methods, five features were finally selected to establish a model. The AUC of the model in the identification of VD were 0.93 and 0.90 for the training cohort and validation cohort, respectively. The sensitivity and specificity of the model were 90% and 85%, respectively. Conclusion CT radiomics of the intervertebral disc is feasible in identifying early degenerative changes caused by scoliosis.
Systematic Search and Evaluation of mobile Apps for Wound Care Available in French-Language in Canada
Authors: Gagnon Julie , Chartrand Julie , Probst Sebastian , Maillet Éric , Reynolds Emily , Chaplain Valérie , St-Jean Heidi , East Raphaelle , Lalonde Michelle 
Published: February 2025

Background Wounds are a significant national health concern, impacting individuals, healthcare systems, and the environment. Despite efforts by organizations to promote evidence-based practices, gaps persist between theory and nurse practice in wound care. Mobile apps show promises in enhancing wound care delivery, but their rapid evolution, including adaptations into different languages such as French, raises concerns about reliability and regulation. Evaluating these apps is crucial for ensuring patient safety and effective wound management. Purpose To review and assess mobile wound care apps available in French for healthcare providers in Canada. Methods A systematic search was conducted across the literature and the two main Canadian online app stores (App Store and Google Play). The included mobile apps underwent quality evaluation using the user version of the Mobile Application Rating Scale (uMARS). Results The initial search retrieved 1,550 apps, of which 260 were screened and 5 included. Included apps were from France and were available on both stores. These apps varied in features, including wound dressing directory ( n = 3), best practices reminders ( n = 2), photography management and digital wound tracking ( n = 1), and total body surface area calculator ( n = 1). Evaluation using uMARS indicated total averages range from 3.52/5 to 4.10/5. The results offer scant insight into the design and evaluation of the apps included. Conclusions The study highlights the need for development and validation of a French wound care app tailored to Canadian healthcare contexts and best practice recommendations, emphasizing collaboration among nurses and stakeholders in technology enhancement for the benefit of Canadians’ health.
Initial real-world experience with ribociclib in advanced breast cancer
Authors: Nawaz Azhar , Zekri Jamal , Rasool Haleem , Ibrahim Refaei 
Published: February 2025

Purpose CDK4/6 inhibitors, such as ribociclib, are recommended in combination with hormonal therapy to treat advanced/metastatic hormone receptor-positive, HER2-negative breast cancer. The objectives of this study are to evaluate the therapeutic outcome and tolerance of ribociclib in patients treated at our institution. Methods The initial cohort of patients who received >1 cycle of ribociclib between December 2018 and March 2022 were included. Rates of adverse events (AEs) related dose reduction and discontinuation of ribociclib were used as a surrogate marker for intolerance. Results Sixty-eight female patients were included. Ribociclib was administered with letrozole or fulvestrant in the first-, second-, third-, and fourth-line palliative hormonal therapy settings in 29 (42.6%), 26 (38.2%), 12 (17.6%) and 1 (1.5%) patients respectively. Adverse events (AEs) related dose reduction was reported in 30 (44%) patients. Ribociclib was permanently discontinued in 42/68 (61.8%) patients [Disease progression 33/68 (48.5%) and AEs 9 (13.2%)]. Objective response was documented in 10/61 (16.4%) evaluable patients. The median progression free survival (PFS) was 18 months (95% CI: 11.7–24.3). The median overall survival (OS) was not reached and 84% of patients were alive at 3 years. Conclusions Although objective response rates were modest in this mixed cohort of heavily pretreated patients, ribociclib combined with letrozole or fulvestrant has shown robust PFS and OS in real-world practice. AEs related treatment discontinuation rate is higher than that reported in clinical trials with stringent inclusion criteria.
Content Analysis of the Portrayal of Prescription Stimulants on TikTok
Authors: Johnson Benjamin , Sun Tianze , Wu Leo , Seal Stella , Stjepanovic Daniel , Chan Gary , Leung Janni 
Published: February 2025

Background: TikTok has become a significant influence on public health perceptions, especially regarding ADHD. With its expansive reach among younger demographics, TikTok content has the potential to shape public understanding and behaviors related to ADHD treatment. This study analyzed how prescription stimulants are depicted on TikTok to assess the potential influence of these portrayals on ADHD stimulant medication demand. Methods: We employed a snowball sampling strategy to collect 1,000 TikTok videos related to prescription stimulants. A systematic content analysis was conducted on a refined dataset of 548 videos, identifying primary categories related to prescription stimulant portrayals. Results: The videos, which predominantly featured young adults, mainly white and female, amassed an average of over 300,000 views per video. Our analysis uncovered four primary categories: Positive Effects, Negative Effects, Context of Use, and Systemic Challenges. Videos frequently depicted substantial improvements in daily functionality and emotional well-being attributed to prescription stimulants, with side effects presented as manageable. The context of use highlighted the broad applications of these medications in daily life, while systemic challenges focused on issues such as healthcare barriers, medication shortages, and stigma. Conclusion: TikTok users’ portrayal of prescription stimulants were predominantly positive, emphasizing improved lifestyles, which may influence medication demand similar to direct-to-consumer advertising, particularly among young women. The depiction of systemic barriers underscores the complexity of accessing treatment, which may disproportionately affect individuals with ADHD and impact treatment adherence, warranting further research into audience reception of this content.
Quantitative ultrasound analysis for non-invasive assessment of hepatic steatosis in metabolic dysfunction-associated steatotic liver disease
Authors: Fan Yunling , Chen Kailing , Zhao Qiannan , Yin Haohao , Zhu Yuli , Xu Huixiong 
Published: February 2025

Objective To evaluate the diagnostic performance of novel tissue attenuation imaging (TAI) and tissue scatter distribution imaging (TSI) tools in detecting and grading hepatic steatosis using controlled attenuation parameter (CAP) as reference standard. Methods A total of 185 participants with suspected metabolic dysfunction-associated steatotic liver disease (MASLD) were prospectively enrolled, and all underwent CAP and quantitative ultrasound (QUS) testing. Correlations between CAP, biological data, TAI and TSI were assessed. The influence factors of TAI and TSI as well as the diagnostic performance of TAI and TSI in detecting hepatic steatosis were evaluated. Results The QUS parameters (TAI and TSI) showed good intra-observer reliability with ICC of 0.972 and 0.777, respectively. The correlation of CAP with TAI was higher than that of TSI (0.724 vs 0.360, P < 0.05). Multivariate Regression analysis showed that CAP was an important influence factor of TAI and TSI ( P < 0.001). The area under the ROC curve (CAP > 250 dB/m) of TAI and TSI tools for detecting hepatic steatosis was 0.876 (95% CI: 0.813–0.923; P < 0.0001) and 0.797(95% CI: 0.724–0.857; P < 0.001), respectively; the sensitivity was 67.18% and 83.21%, the specificity was 95.65% and 69.57%, and the cut-off values were 0.93 dB/cm/MHz and 91.28, respectively. When TAI and TSI were combined, the area under the ROC curve was 0.881, with a sensitivity of 80.92% and a specificity of 82.61%. The Delong test showed that the combined diagnosis of TAI and TSI was equivalent to the use of TAI alone ( P > 0.05). Conclusion TAI and TSI provided good intra-observer reliability, correlated well with CAP, and helped to detect and stage hepatic steatosis.
Fractal characteristics of micropore structure of Taiyuan Formation bauxite reservoir in Longdong area of Ordos Basin
Authors: Dong Yue , Yang Xiaochen , Hu Chenguanng , Zhou Jiang , Li Yongjin , Qin Qin , Yin Zhaoyang , Li Haoyuan , Zhu Yushuang 
Published: February 2025

As an unconventional gas reservoir, bauxite gas reservoirs have often been studied as weathered crust cover layers rather than reservoirs in the past. The Taiyuan Formation bauxite in the Longdong area of the Ordos Basin has achieved breakthroughs, and some wells have obtained industrial airflow. Therefore, it is necessary to conduct basic geological research on the bauxite reservoir. The application of casting thin sections, scanning electron microscopy (SEM), X-ray diffraction (XRD), high-pressure mercury injection (HPMI), and low-temperature nitrogen adsorption (L-TNA) techniques provides a comprehensive framework for studying reservoir characteristics as well as the micropore fractal structure. The results indicate that (1) the bauxite reservoir has logging characteristics of high natural gamma (500API) and low acoustic wave time difference (60–90 us/m), with natural gamma being the most critical parameter in identifying the bauxite reservoir in the logging curve. (2) The bauxite rocks in the Longdong region belong to sedimentary formation, and three types of micro ancient landforms (buried pits, terraces, and grooves) have different lithological combinations. Among them, the combination of the bauxite rocks in the buried pits and carbonaceous mudstones has been subjected to freshwater leaching for a long time, and the thickness of the bauxite rocks is the largest. (3) The pores of bauxite reservoir are mainly dissolution pores within particles, intergranular dissolution pores, intergranular pores, and microcracks. The average porosity of the reservoir is 8.49%, and the average permeability is 0.261 × 10−3 μm2, with a low permeability standard greater than 0.4 accounting for 17.19%. (4) The fractal dimension D2 of micropore D1 and nanopore D2 were calculated by high-pressure mercury injection and nitrogen adsorption experiments, respectively. Through correlation analysis, we found that the fractal dimension D2 (calculated from nitrogen adsorption data) more effectively characterizes the comprehensive quality of nanopores within the bauxite reservoir compared to the fractal dimension D1 obtained from high-pressure mercury injection (HPMI). We have established classification evaluation standards: Type I D1 is 2.2∼2.6, Type II D1 is 2.6∼2.8, and Type III D1 is 2.8∼3. Among them, Class I bauxite reservoir is a high-quality reservoir and can be the preferred target for exploration in the study area.
Transcriptional Regulation of NUPR1 by MYH11 Activates PI3 K/AKT and Promotes Bladder Cancer Progression Through Ferroptosis and M2 Polarization of Macrophages
Authors: Zhang Lifeng , Zhang Li , Shi Zebin , Mi Yuanyuan , Zhang Lei , Shi Xiaokai , Gao Shenglin , Zuo Li 
Published: February 2025

Background NUPR1 is a small molecule protein that plays an important role in tumor progression and drug resistance. Our previous study found that NUPR1 promotes the progression of bladder cancer, but the specific mechanism is still unclear. MYH11 encodes the smooth muscle myosin heavy chain and belongs to the conventional myosin family. MYH11 has been found to be associated with a variety of malignant tumors. Methods We identified MYH11 as an upstream regulator of NUPR1 using a bioinformatics approach and tested this hypothesis by knocking down MYH11 and ChIP-qPCR. Subsequently, we verified the association of MYH11 and NUPR1 with the PI3 K/AKT pathway by WB. In addition, gene enrichment results showed that the effect of NUPR1 on bladder cancer was related to ferroptosis and M2 macrophage polarization. We examined ferroptosis metabolites in bladder cancer cells overexpressing NUPR1 and expression of the M2 macrophage marker CD206 in NUPR1 overexpression or MYH11 knockdown bladder cancer cells. Results Bioinformatics results showed that MYH11 was positively correlated with NUPR1, and there may be a mutual binding site at the promoter of NUPR1. Knockdown of MYH11 decreased NUPR1 expression, and ChIP-qPCR showed that MYH11 bound to the promoter of NUPR1. Subsequently, WB results showed that MYH11 knockdown inhibited the PI3 K/AKT pathway, whereas NUPR1 overexpression activated this pathway. After adding ferroptosis activator, the viability of bladder cancer cells decreased, and the content of Fe2+ and MDA increased. However, ferroptosis was significantly inhibited after overexpression of NUPR1. Knockdown of MYH11 inhibited M2 macrophage polarization, while overexpression of NUPR1 promoted this process. Conclusion This study suggests that MYH11 activates the PI3 K/AKT pathway by up-regulating the expression of NUPR1, and promotes bladder cancer progression by inhibiting ferroptosis and promoting M2 polarization of macrophages.
Current Methods Used to Evaluate Glenoid Bone Loss: A Survey of Orthopaedic Surgeons
Authors: Huddleston Hailey , Credille Kevin , Wang Zachary , Cregar William , Lansdown Drew Anderson , Chahla Jorge , Garrigues Grant E. , Verma Nikhil N. , Yanke Adam B. 
Published: February 2025

Background: Evaluation of glenoid bone loss is critical in preoperative planning, as bone loss >13.5% has been associated with worse clinical outcomes. While 3‐dimensional computed tomography (3D CT) and the Pico method have been the gold standard in bone loss evaluation, it is unclear how most orthopaedic surgeons evaluate for bone loss in practice. Purpose: To investigate the techniques used by orthopaedic surgeons to measure glenoid bone loss. Study Design: Cross-sectional study. Methods: A 12‐question survey was sent to members of the AOSSM and Arthroscopy Association of North America. This survey included questions regarding the participants’ demographic information, typical surgical practice and volume, and glenoid bone loss identification method. Friedman testing with multiple comparisons using Bonferroni correction was used to evaluate the ordinal variable, use frequency, while Kruskal-Wallis testing and Spearman correlations were used to evaluate the role of surgeon demographic factors on method usage. Results: Overall, 171 orthopaedic surgeons responded to the survey. Participating surgeons were from a variety of locations, practice settings, and years in practice; 91.1% of respondents said that they routinely measure glenoid bone loss. The imaging modality most commonly used for bone loss evaluation was 3D CT, followed by 2‐dimensional (2D) magnetic resonance imaging, then 2D CT and radiographs. Percentage diameter loss was the most commonly used method of bone loss evaluation. The intraoperative probe length method was used occasionally, the Pico method was used rarely, and the chord length method was never used. There was no significant effect of time in practice or practice location on bone loss methods used. Surgeons in private practice ( P = .022) or other settings ( P = .015) had a higher frequency of using the intraoperative probe length method compared with those in the military. Conclusion: Overall, this study highlights the inconsistency in surgeon evaluation of glenoid bone loss in shoulder instability, despite good evidence of its clinical importance, especially in preventing recurrent instability. This lack of consistency may be mitigated with the establishment of best practice guidelines or accepted algorithms for evaluation and assessment of glenoid bone loss in shoulder instability.
Indonesian Nursing Students’ Perceptions of Caring in Clinical Setting: A Descriptive Qualitative Study
Authors: Mariyanti Herdina , Yeo Kee Jiar , Klankhajhon Sirikanok , Arifin Hidayat 
Published: February 2025

Background Clinical education is crucial in nursing programs for preparing students to deliver compassionate, high-quality care. However, research on nursing students’ perceptions and expressions of caring behaviors in clinical settings is limited, particularly in Indonesia. This study aims to explore Indonesian nursing students’ views on caring behaviors in clinical settings, addressing a significant gap in nursing education research within the Indonesian context. Methods A descriptive phenomenology research design was employed in this study. Nursing students’ views and perceptions of caring were obtained through telephone interviews with semistructured questions. The research participants comprised 20 undergraduate nursing students undergoing clinical education at nursing education institutions in Surabaya, Indonesia, obtained through purposive sampling. The recorded interviews were transcribed and analyzed using a phenomenological method. To ensure reliability and validity in the data analysis process, grounded in Husserlian phenomenology and Giorgi's phenomenological method were employed. Results Seven key themes related to the perceptions of caring behavior emerged from the phenomenological analysis: (1) Caring as trying one's best to meet patients’ needs; (2) Caring as a central value of nursing practice; (3) Caring as compassion; (4) Caring as helping each other; (5) Caring as awareness of patients’ individual needs; (6) Caring as professionalism; and (7) Caring as support. Conclusion The findings of this study are expected to significantly improve nursing student application of caring behavior in the clinical setting. Increasing understanding and application of caring behavior in nursing students can have a positive impact on clinical practice. This study is useful as a guide for educators to help nursing students improve their caring practice in the clinical setting.