bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of primary malignant melanoma of the esophagogastric junction with abscopal effect after nivolumab administration
Authors: Yamaguchi Takahisa , Fushida Sachio , Kinoshita Jun , Saito Hiroto , Shimada Mari , Terai Shiro , Moriyama Hideki , Okamoto Koichi , Nakamura Keishi , Ninomiya Itasu , Inaki Noriyuki 
Published: December 2021

Abstract
Background
The abscopal effect is a rare phenomenon in which local irradiation causes tumor regression outside the irradiated area. There have been no reports of abscopal effect in patients with gastrointestinal melanoma with metastasis. Here, we report a case of primary malignant melanoma of the esophagogastric junction with abscopal effect after long-term treatment with nivolumab.

Case presentation
A 75-year-old woman was referred to our hospital with a gastroesophageal lesion. Upper gastrointestinal endoscopy revealed a raised lesion on the posterior wall of the greater curvature of the cardia and tenderness in the lower esophagus. Immunostaining of the tumor biopsy showed positive staining for Melan-A, human melanoma black-45 (HMB45), and S-100, indicating malignant melanoma of the esophagogastric junction. Contrast-enhanced computed tomography (CT) of the abdomen showed a mildly stained lesion protruding into the cardiac part of stomach and enlarged surrounding lymph nodes. The patient was diagnosed with malignant melanoma of the esophagogastric junction and proximal gastrectomy with lower esophagus resection was performed. Histological examination showed large, round tumor cells with nuclear atypia. Immunostaining was positive for Melan A, HMB45, S-100 protein, and SRY-box transcription factor 10, and the final diagnosis was malignant melanoma of the esophagogastric junction, with regional lymph node metastases. Three months after surgery, follow-up CT indicated left pleural metastasis; therefore, the patient was administered nivolumab, an immune checkpoint inhibitor (ICI). Following three courses of nivolumab, the patient exhibited grade 3 renal dysfunction (Common Terminology Criteria for Adverse Events version 5.0). After that, we have not administered nivolumab treatment. Five months after the development of renal dysfunction, a CT scan demonstrated an unstained nodule within the pancreatic, and the patient was diagnosed with pancreatic metastasis; intensity-modulated radiotherapy was performed. Six months later, CT revealed pancreatic nodule and pleural metastasis was shrunk; after an additional 2 months, pleural metastasis and effusion had disappeared. The patient is alive with no additional lesions.

Conclusions
We report a case of primary malignant melanoma of the esophagogastric junction with an abscopal effect following nivolumab treatment. The findings of this case report suggest that ICIs in combination with radiotherapy may be effective for treating metastatic or recurrent malignant melanoma of the gastrointestinal tract.
Polish immigrants and their children in Canada and Sweden, employment status and income patterns
Authors: Pendakur Ravi , Bevelander Pieter 
Published: December 2021

AbstractUsing a combination of logit, and OLS regressions we ask if the labour force outcomes for Polish immigrants differ across two immigration policy regimes (Canada and Sweden). Specifically, we compare the employment and earnings prospects of Polish immigrants and their children in Canada and Sweden using data that is similar in quality and timing. We find that in general, Polish immigrants, while facing substantial penalties compared to native-born workers fare better in Canada than in Sweden in terms of employment and income. As expected, second generation Poles fare much better than their immigrant counterparts in terms of employment and earnings differentials and have similar outcomes to the native-born majority in both countries. Membership in the EU fundamentally changed migration flows from Poland. In light of this we also look at how post-2004 Polish migrants have fared in both Canada and Sweden.
Morphological variables restrict flower choice of Lycaenid butterfly species: implication for pollination and conservation
Authors: Mukherjee Subha Shankar , Hossain Asif 
Published: December 2021

Abstract
Background
Butterflies make an important part for plant-pollinator guild. These are nectar feeder or occasionally pollen feeder and thus proboscis of the butterfly species are considered as one of the most important variable in relation to the collection of food from plants. In butterfly-plant association, nectar source is principally determined by quality of nectar, corolla length, and nectar quantity. For the butterfly, nectar uptake is determined by proboscis length because flowers with long corolla restrict butterfly species containing shorter proboscis. Empirical studies proved that butterfly species with high wing loading visit clustered flowers and species with low wing loading confined their visit to solitary or less nectar rich flowers. The present study tries to investigate the flower preference of butterfly species from Lycaenidae family having very short proboscis, lower body length, lower body weight and wing span than the most species belonging from Nymphalidae, Pieridae, Papilionidae, and Hesperiidae.

Results
Butterflies with shorter proboscis cannot access nectar from deeper flower. Although they mainly visit on less deeper flower to sucking nectar, butterflies with high wing loading visits clustered flowers to fulfill their energy requirements. In this study, we demonstrated flower choice of seven butterfly species belonging to Lycanidiae family. The proboscis length maintains a positive relationship with body length and body weight. Body length maintains a positive relationship with body weight and wing span. Wing span indicate a strong positive relationship with body weight. This study proved that these seven butterfly species namely Castalius rosimon (CRN), Taracus nara (TNA), Zizinia otis (ZOT), Zizula hylax (ZHY), Jamides celeno (JCE), Chilades laius (CLA), and Psuedozizeeria maha (PMA) visit frequently in Tridax procumbens (TPR), Ocimum americanum (OAM) and Syndrella nodiflora (SNO). The species do not visit Lantana camara (LCA) and Catharanthus roseus (CRO) plants.

Conclusion
The present study proved that butterfly species visits frequently in Tridax procumbens (TPR), Ocimum americanum (OAM) but less frequently in Syndrella nodiflora (SNO). So, that study determined the butterfly species helps in pollination of these herbs that in turn helps the conservation of these butterfly species.
Honey bees and their brood: a potentially valuable resource of food, worthy of greater appreciation and scientific attention
Authors: Ghosh Sampat , Meyer-Rochow Victor Benno , Jung Chuleui 
Published: December 2021

AbstractDespite the consumption of bee brood in several parts of the world, particularly in the tropical areas, the practice has received comparatively little attention. We have reviewed all the available information on the nutrient composition and functional properties of different developmental stages of honey bee workers belonging to different species and subspecies. Noticing the competent nutrient composition of, in particular, honey bee brood, pupae, and prepupae, we suggest that they could be a potential source of human nutrition as well as animal feed. Moreover, drone brood is an ideal candidate for use as a food or as food ingredient. However, to analyze the functional properties of different honey bee species remains a task for further analysis.
Serum Dickkopf-1 as a potential prognostic marker in patients with rheumatoid arthritis
Authors: Ali Dina A. , Esmail Doaa Mohamed , Mohammed Haidy Ali , Yonis Reham Lotfy , El-Sharaby Radwa Mahmoud 
Published: December 2021

Abstract
Background
Rheumatoid arthritis (RA) is a disease of an autoimmune nature that involves all types of joints structures and manifested by chronic joints inflammations and thus their erosions and damage. Dickkopf-1 (DKK-1) is a molecule that has an inhibitory regulation of wingless/integrated genes (Wnt) pathway and has a major role in models of animals with arthritis or joint destruction. Increased DKK-1 levels are implicated in higher resorption of the bone in cases of rheumatoid arthritis and thus with higher probability for joint deformities, while low levels associated with formation of new bone by osteoblasts, we aimed to study the prognostic role of circulating Dickkopf-1 in rheumatoid arthritis.

Results
The present study revealed that the DKK-1 levels were significantly increased in RA patients in relation to the control group (P=0.001). We found a significant positive correlation between DKK-1 level and ESR (P=0.001), Disease Activity Score (DAS 28) (P=0.001), the disease duration (P=0.001), and the presence of bone erosions in plain X-ray of hands (P =0.001). Moreover, we revealed that, at cutoff value 2150, the DKK-1 in RA has 90% sensitivity and 85% specificity.

Conclusions
DKK-l serum level can be used as a potential prognostic biomarker for monitoring of joint erosions and destruction in RA patients. Furthermore, it could be a possible target molecule in the future therapy to control the process of joint destruction.
MG2C: a user-friendly online tool for drawing genetic maps
Authors: Chao Jiangtao , Li Zhiyuan , Sun Yuhe , Aluko Oluwaseun Olayemi , Wu Xinru , Wang Qian , Liu Guanshan 
Published: December 2021

AbstractGenetic map is a linear arrangement of the relative positions of sites in the chromosome or genome based on the recombination frequency between genetic markers. It is the important basis for genetic analysis. Several kinds of software have been designed for genetic mapping, but all these tools require users to write or edit code, making it time-costing and difficult for researchers without programming skills to handle with. Here, MG2C, a new online tool was designed, based on PERL and SVG languages.Users can get a standard genetic map, only by providing the location of genes (or quantitative trait loci) and the length of the chromosome, without writing additional code. The operation interface of MG2C contains three sections: data input, data output and parameters. There are 33 attribute parameters in MG2C, which are further divided into 8 modules. Values of the parameters can be changed according to the users’ requirements. The information submitted by users will be transformed into the genetic map in SVG file, which can be further modified by other image processing tools.MG2C is a user-friendly and time-saving online tool for drawing genetic maps, especially for those without programming skills. The tool has been running smoothly since 2015, and updated to version 2.1. It significantly lowers the technical barriers for the users, and provides great convenience for the researchers.
Assessment of the optimal level of basalt pozzolana blended cement replacement against concrete performance
Authors: Moawad Mohamed S. , Younis Shimaa , Ragab Abd EL- Rahman 
Published: December 2021

AbstractDifferent additional cementitious materials can be used to partially replace cement in concrete. these are used in concrete as a partial replacement for cement to reduce the effect of environmental pollution, which can lead to serious health issues. Therefore, it is critical to use locally available pozzolanic materials as a partially replacement for cement because these materials are less expensive than Portland cement and are more environmentally friendly without sacrificing concrete quality. Pozzolana made from basalt natural material was tested for the best amount of weight percentage replacement as a blinding component in cements in this study. Various percentage of basalt as a partial replacement weight percentage of ordinary Portland cement by 7.5%, 15%, and 22.5% is carried out. effect of basalt on workability, setting time, compressive strength, modulus of elasticity, tensile strength, flexural strength, and water absorption were conducted. The parameters were studied and monitored by tested a fresh and hardened concrete samples at ages of 7 days, 28 days, 56 days, and 90 days. Based on the test results, it is concluded that the optimal content of basalt as replacement of ordinary Portland cement in concrete mix is 15%.
Executive Dysfunction and the Prefrontal Cortex
Authors: Jones David T. , Graff-Radford Jonathan 
Published: December 2021

ABSTRACT

PURPOSE OF REVIEW
This article summarizes the cognitive and behavioral functions of the prefrontal cortex with an emphasis on executive cognitive functions and the clinical consequences associated with executive dysfunction. The clinical manifestations of lesions to the lateral prefrontal, orbitofrontal, medial prefrontal, and frontopolar cortex are reviewed.

RECENT FINDINGS
Traditional lesion studies have emphasized the role of a brain region in controlling a cognitive function. With advances in neurology, neuropsychology, and neuroimaging, the participation of the prefrontal cortex in large-scale networks has been established with recognition that cognitive dysfunction can arise not only from a lesion within a network but also from degenerative disease targeting these large-scale, dynamic neural networks. Although executive dysfunction can result from frontal lobe injury, this article highlights the role of distributed processes subserving executive functions. An atypical phenotype of Alzheimer disease has been described that selectively targets parietal-temporal-frontal networks important for core executive functions.

SUMMARY
Executive function comprises working memory, cognitive flexibility, and inhibition and depends on top-down (ie, goal-driven) control of distributed processes occurring throughout the brain. The exact behavioral output (ie, function) depends on the content of the processes being controlled. Prefrontal cortex regions serve key cognitive functions related to social, emotional, and motivational aspects of behavior. The dorsal lateral prefrontal cortex plays a role in working memory, goal-driven attention, task switching, planning, problem-solving, and novelty-seeking. The ventral lateral prefrontal cortex plays a role in inhibition, response selection, and monitoring; the medial prefrontal cortex in self-knowledge, motivation, emotional regulation, and updating goal-directed behavior; the orbitofrontal cortex in personality, inhibition, and emotional and social reasoning. Although dysexecutive syndromes have been traditionally associated with dorsolateral prefrontal cortex injury, it is now recognized that they can also result from an impaired parietal-temporal-frontal system, which is targeted in a distinct form of atypical Alzheimer disease. This dysexecutive Alzheimer phenotype is characterized by impaired task performance on a wide battery of neuropsychological tests and simple daily tasks that require executive control. In contrast, dysexecutive syndromes more localized to the frontal lobe involve impaired executive control of social, emotional, and motivational aspects of behavior.
Abnormal brain development of monoamine oxidase mutant zebrafish and impaired social interaction of heterozygous fish
Authors: Baronio Diego , Chen Yu-Chia , Panula Pertti 
Published: December 2021

ABSTRACT
Monoamine oxidase (MAO) deficiency and imbalanced levels of brain monoamines have been associated with developmental delay, neuropsychiatric disorders and aggressive behavior. Animal models are valuable tools to gain mechanistic insight into outcomes associated with MAO deficiency. Here, we report a novel genetic model to study the effects of mao loss of function in zebrafish. Quantitative PCR, in situ hybridization and immunocytochemistry were used to study neurotransmitter systems and expression of relevant genes for brain development in zebrafish mao mutants. Larval and adult fish behavior was evaluated through different tests. Stronger serotonin immunoreactivity was detected in mao+/− and mao−/− larvae compared with their mao+/+ siblings. mao−/− larvae were hypoactive, and presented decreased reactions to visual and acoustic stimuli. They also had impaired histaminergic and dopaminergic systems, abnormal expression of developmental markers and died within 20 days post-fertilization. mao+/− fish were viable, grew until adulthood, and demonstrated anxiety-like behavior and impaired social interactions compared with adult mao+/+ siblings. Our results indicate that mao−/− and mao+/− mutants could be promising tools to study the roles of MAO in brain development and behavior.
This article has an associated First Person interview with the first author of the paper.
Different patterns of chronic hypoxia lead to hierarchical adaptive mechanisms in goldfish metabolism
Authors: Thoral Elisa , Farhat Elie , Roussel Damien , Cheng Hang , Guillard Ludovic , Pamenter Matthew E. , Weber Jean-Michel , Teulier Loïc 
Published: December 2021

ABSTRACT
Some hypoxia-tolerant species, such as goldfish, experience intermittent and severe hypoxia in their natural habitat, causing them to develop multiple physiological adaptations. However, in fish, the metabolic impact of regular hypoxic exposure on swimming performance in normoxia is less well understood. Therefore, we experimentally tested whether chronic exposure to constant (30 days at 10% air saturation) or intermittent hypoxia (3 h in normoxia and 21 h in hypoxia, 5 days a week) would result in similar metabolic and swimming performance benefits after reoxygenation. Moreover, half of the normoxic and intermittent hypoxic fish were put on a 20-day normoxic training regime. After these treatments, metabolic rate (standard and maximum metabolic rates: SMR and MMR) and swimming performance [critical swimming speed (Ucrit) and cost of transport (COT)] were assessed. In addition, enzyme activities [citrate synthase (CS), cytochrome c oxidase (COX) and lactate dehydrogenase (LDH)] and mitochondrial respiration were examined in red muscle fibres. We found that acclimation to constant hypoxia resulted in (1) metabolic suppression (−45% SMR and −27% MMR), (2) increased anaerobic capacity (+117% LDH), (3) improved swimming performance (+80% Ucrit, −71% COT) and (4) no changes at the mitochondrial level. Conversely, the enhancement of swimming performance was reduced following acclimation to intermittent hypoxia (+45% Ucrit, −41% COT), with a 55% decrease in aerobic scope, despite a significant increase in oxidative metabolism (+201% COX, +49% CS). This study demonstrates that constant hypoxia leads to the greatest benefit in swimming performance and that mitochondrial metabolic adjustments only provide minor help in coping with hypoxia.
Mindfulness in Athletes
Authors: Anderson Scott A. , Haraldsdottir Kristin , Watson Drew 
Published: December 2021

Abstract
Interventions to promote athlete health and performance have traditionally been focused on the physical elements of injury and training. More recently, however, increasing attention has been placed on the mental aspects of athlete health, with emerging evidence suggesting that injury risk and athletic performance are significantly affected by athlete well-being. Mindfulness meditation has been shown to have significant benefits for a number of physical and mental health outcomes in various clinical populations, and recent research has explored how mindfulness may enhance athletic performance, improve athlete mental health, reduce injury risk, and perhaps even facilitate recovery from injury. As awareness of mindfulness as a noninvasive, low-risk, and accessible intervention increases in the Western society, use among athletes has increased as well. Health care providers should be aware of this evidence in order to guide athletes regarding the use of mindfulness as an intervention to potentially improve athlete health and performance.
ИССЛЕДОВАНИЕ ВЗАИМОСВЯЗИ МЕЖДУ СОЦИОНИЧЕСКИМ ТИПОМ И ТИПАМИ ПРОФЕССИЙ ПО ХОЛЛАНДУ
Authors: Kovalenko Roman K. , Strutinsky Sergey V. , Zvonareva Nataliya A. 
Published: December 2021

Цель. Статья посвящена исследованию профориентационных методов, а именно – обоснованию конструктной валидности использования соционической модели для профориентационной деятельности.
Метод или методология проведения работы. В работе использовались методика определения соционического типа, дифференциально-диагностический опросник Е.А. Климова, опросник Дж. Холланда в адаптации Г.В. Резапкиной и расчет рангового бисериального коэффициента корреляции.
Результаты. Корреляционный анализ выявил наличие положительной связи между соционическим полюсом «логика» с «реалистичным» и «конвенциональным» типами по Холланду, а также отрицательные связи с «социальным» и «артистическим» типами. Соционический полюс «экстраверсия» положительно коррелирует с «предприимчивым» типом и отрицательно с «реалистичным» и «интеллектуальным» типами. Также выявлена корреляция соционического полюса «конструктивизм» с «артистичным» типом. Также в работе рассмотрены корреляции шкал опросника Холланда с типами профессий дифференциально-дидактического опросника Е.А. Климова. Полученные результаты соотносятся с существовавшими ранее гипотезами.
Область применения результатов. Полученные результаты помогут специалистам профориентологам, использующим на практике в т.ч. и методы соционики, чтобы повысить качество своей работы. Также результаты исследования показывают перспективность дальнейшего развития исследований конструктной валидности методов соционики.
Local device infection successfully treated without pacemaker removal in a neonate: a case report
Authors: Scrascia Giuseppe , Grimaldi Anna Maria Pia , Troise Dario , Catucci Silvana , Maggio Giulio , Vairo Ugo , Giudice Giuseppe , Scalzo Gabriele 
Published: December 2021

Aims: Local device infection is a serious complication, especially in neonates. Complete device removal is the gold standard treatment for cardiac device infection; however, in selected cases alternative strategies could be adopted. We describe a case of a 14-day-old neonate, weighing 2.5kg, who had undergone epicardial double chamber pacemaker implantation for a congenital complete atrioventricular block. The generator pocket was created in the epigastric area below the rectus abdominis. At six days after implantation, pocket infection was found; blood cultures and the transoesophageal echocardiogram were normal. Due to the low weight of the neonate, and the limited possibility of finding a new comfortable site for housing the generator far from the infected area, we opted for a conservative strategy. We successfully applied a combination of antibiotic therapy, a vacuum-assisted wound closure system (KCI, Germany) for 40 days, and then skin transfer flap from the right flank without device removal. At one-year follow-up there were no local or systemic signs of infection.