bluuebunny/crossref_metadata_2025_split huggingface dataset:
METHODOLOGICAL PROJECTS FOR ORGANIZING SEMANTIC READING OF AN INFORMATICS TEXTBOOK
Authors: Malova I. Е. , Timohina A. S. 
Published: June 2021

The purpose of the research presented in the article was to identify the problems of organizing semantic reading by future informatics teachers and to determine ways to solve these problems. The research methodology provided for the following stages: 1) the formulation of a task for students — future informatics teachers — to create a methodological project for organizing the semantic reading of an informatics textbook and providing examples of projects completed by other students; 2) students' performance of the assignment using a computer presentation, on the slides of which a fragment of the text of the textbook is presented and with the help of which a dialogue with the students is carried out; 3) analysis and correction, if necessary, of the methodological actions of the authors of the projects; 4) generalization of the encountered problems and ways to overcome them. Students are given the opportunity at any stage to get acquainted with the projects carried out by other students. As a result, it was confirmed the effectiveness of the selection of objects of semantic reading and the use of the method "Make up questions to which there are answers in the text", additional questions, the "curtain" method; the difficulties of students in organizing the semantic reading of solving problems were determined; a technique has been developed to overcome these difficulties. The value of the research lies in improving the methodological experience of the participants in experimental work, in the possibility of transferring the technology of methodological projects for organizing semantic reading to other topics of informatics, to other academic subjects, in the possibility of using the developed methodological projects in practice both at school when teaching students and at university when working with future informatics teachers.
Microorganismos empleados para la biorremediación de efluentes mineros con cianuro
Authors: Apaza Aquino Hugo , Rojas Machaca Yoselin P. , Mamani Mamani Eneida , Chura Palli Vianey D. 
Published: June 2021

Uno de los mayores problemas ambientales que se tiene es referente a los efluentes mineros con cianuro, por su alto grado de toxicidad ocasiona impactos altamente significativos en el ecosistema en general. A pesar de que existen diversas tecnologías para su tratamiento, la biorremediación es una alternativa potencial por ser amigable con el medio ambiente. Se tiene como objetivo principal analizar los principales microorganismos empleados para llevar acabo procesos de biorremediación de efluentes mineros con cianuro. Se realizó una revisión de las distintas fuentes de información de microorganismos biorremediadores de cianuro. Hallándose que se reportan una amplia diversidad de microorganismos que se pueden emplear como agentes biológicos potenciales para biorremediar el cianuro, entre las que sobresalen las del género de Pseudomonas y Bacillus; los principales factores que se debe tener en cuenta para lograr altas eficiencias son el pH, temperatura, nutrientes, concentración de la biomasa y concentración de cianuro. La biorremediación empleando microorganismos cada vez va tomando mayor posición para remediar contaminantes como el cianuro pero aun así en el Perú faltan mayores estudios a nivel piloto y planta para demostrar su eficiencia que se logra a nivel laboratorio.
ANALISIS STRATEGI PEMASARAN DENGAN METODE SWOT DAN BCG DI PT. XYZ
Authors: Laksana Tiara Nindya , Waluyo Minto 
Published: June 2021

Analisis strategi pemasaran sangatlah penting untuk setiap perusahaan agar dapat bersaing dengan competitor-competitor yang ada. PT. XYZ adalah perusahaan furniture yang memproduksi berbagai jenis perabotan berbahan dasar kayu. Kayu yang sering digunakan ada-lah kayu Medium Density Fibreboard (MDF) untuk membuat meja dan lemari. Permasalahan yang dihadapi perusahaan adalah mempunyai beberapa produk yang dalam 3 tahun terakhir ini mengalami stagnan penjualan atau bisa dikatakan tidak ada perubahan/peningkatan penjualan, yaitu kitchen set dan meja TV. Tujuan penelitian untuk menganalisis strategi pemasa-ran dengan menggunakan metode Strength, Weakness, Opportunity, dan Threat (SWOT) dan Bos-ton Consulting Group (BCG) di PT. XYZ. SWOT adalah alat untuk menganalisis suatu kekuatan dan kelemahan perusahaan serta peluang dan ancaman dari faktor eksternal. Boston Conslting Group merupakan alat untuk posisi perusahaan dengan mempertimbangkan nilai pangsa pasar relatif dan tingkat pertumbuhan pasar. Hasil perhitungan didapatkan untuk metode SWOT produk meja TV dan kitchen set dari PT. XYZ berada di kuadran I, maka posisi ini membuktikan bahwa produk tersebut sudah mantap untuk dipasarkan. Sedangkan untuk BCG, kedua produk tersebut berada di kuadran anjing (dog) dimana pada kondisi perusahaan menghadapi pangsa pasar rendah dan kondisi pertumbuhan pasar yang rendah.
Kata Kunci : Strategi Pemasaran, SWOT, Boston Consulting Group
Numerical Study on Natural Convection of Alumina-water Nanofluid in a Square Cavity with Two Localized Heat Sources on Adjacent Surfaces
Authors: Shaik Farooq , Domakonda Vinay Kumar 
Published: June 2021

In the present work, results of a numerical study carried out using finite volume method, to investigate the fluid flow and heat transfer characteristics of Alumina ( Al2O3 ) nanoparticles in the base fluid (water) in a square cavity under natural convection mode are presented. The Semi Implicit Method for Pressure Linked Equations (SIMPLE) algorithm was used to solve the discretized momentum and energy equations. Constant temperature heat sources of same strength are placed on bottom and left vertical surfaces whereas the right surface was kept cold, while the top surface was maintained as adiabatic. The impact of Rayleigh number (RaN) ( 1000 to 106 ) and nanoparticles volume fraction (Φ = 0 %, 5 %, 10 %, 15 % and 20 %) on fluid and heat flow characteristics were numerically investigated and presented in the form of streamlines, isothermal lines, mid line horizontal and vertical velocity components, local Nusselt number ( Nuloc ) and average Nusselt number ( Nuavg ). The obtained results indicate, for lower RaN ( i.e; 103 ), conduction dominates over convection near heated surfaces and results in lower fluid velocities and poor heat transfer. For higher values of RaN ( RaN = 105 and 106 ) and volume fraction of nanoparticles, there was a significant increase in mid horizontal and vertical velocity components, Nuloc and Nuavg due to increase in convective heat transfer and thermal conductivity of nanofluid.
Research libraries as digital publishers: The foreign experience
Authors: Savitskaya T. E. 
Published: June 2021

The author discusses the current experience of building the service of digital science publishing obtained by the libraries in the Western countries. She emphasizes that this process is incorporated into further informatization of libraries and their increasing role in managing science data. The digital publications integrate a number of interrelated programs comprising the whole cycle of scientific data management accomplished within the wider context of innovations. Digital publishing is a new type of library activities; it requires integrating competences of modern librarians (i.e. content selection, data supervising, metadata management, building digital collections, their preservation and archiving) and publishers (monitoring new trends in science and technology, selecting materials for publication, abstracting, scientific editing, developing marketing strategies).For the first time in the domestic library studies, the dynamics of this service in foreign countries is examined based on Library Publishing Directory for 2013– 2018. The author compares digital publishing services in four university libraries in different world regions and offers the findings of preliminary analysis of online publication services in foreign research libraries.
Assessment of Genetic Stability of Micropropagated Bambusa balcooa Roxb. using RAPD Marker
Authors: Suwal Meena Maiya , Lamichhane Janardan , Gauchan Dhurva Prasad 
Published: June 2021

Bambusa balcooa Roxb. was in vitro propagated by optimizing protocol using nodal segment from secondary branches with 100% success in MS liquid media containing 100 mg/l Myo-inositol, 3% sucrose supplement with 4.4 - 26.64 μM BAP for shoot multiplication, and 2.69 - 32.26 μM NAA for root induction. The highest shoot multiplication (14.53 ± 0.33 folds), shoot length (5.9 ± 0.6 cm), shoot number per explants (4.0 ± 0.24), and rooting (89.3 ± 0.33%) was obtained in MS liquid media supplement with 13.32 μM BAP (shooting) and 26.88 μM NAA (rooting) and 1% aqueous leaf extract of Artemisia vulgaris L. (EAV). Twenty RAPD (Random amplified Polymorphic DNA) primers were used individually to amplify DNA of tissue culture-raised plants and the mother plant where 8 primers yielded monomorphic banding patterns with reproducible, clear, scorable bands (2.8 per primer) ranging from 250 to 1800 bp respectively which revealed the micropropagated plants of B. balcooa retained their genetic stability.
Plant Tissue Cult. & Biotech. 31(1): 81-95, 2021 (June)
Acute Myocardial Infarction Detection Using Deep Learning-Enabled Electrocardiograms
Authors: Chen Xiehui , Guo Wenqin , Zhao Lingyue , Huang Weichao , Wang Lili , Sun Aimei , Li Lang , Mo Fanrui 
Published: June 2021

Background: Acute myocardial infarction (AMI) is associated with a poor prognosis. Therefore, accurate diagnosis and early intervention of the culprit lesion are of extreme importance. Therefore, we developed a neural network algorithm in this study to automatically diagnose AMI from 12-lead electrocardiograms (ECGs).Methods: We used the open-source PTB-XL database as the training and validation sets, with a 7:3 sample size ratio. Twenty-One thousand, eight hundred thirty-seven clinical 12-lead ECGs from the PTB-XL dataset were available for training and validation (15,285 were used in the training set and 6,552 in the validation set). Additionally, we randomly selected 205 ECGs from a dataset built by Chapman University, CA, USA and Shaoxing People's Hospital, China, as the testing set. We used a residual network for training and validation. The model performance was experimentally verified in terms of area under the curve (AUC), precision, sensitivity, specificity, and F1 score.Results: The AUC of the training, validation, and testing sets were 0.964 [95% confidence interval (CI): 0.961–0.966], 0.944 (95% CI: 0.939–0.949), and 0.977 (95% CI: 0.961–0.991), respectively. The precision, sensitivity, specificity, and F1 score of the deep learning model for AMI diagnosis from ECGs were 0.827, 0.824, 0.950, and 0.825, respectively, in the training set, 0.789, 0.818, 0.913, and 0.803, respectively, in the validation set, and 0.830, 0.951, 0.951, and 0.886, respectively, in the testing set. The AUC for automatic AMI location diagnosis of LMI, IMI, ASMI, AMI, ALMI were 0.969 (95% CI: 0.959–0.979), 0.973 (95% CI: 0.962–0.978), 0.987 (95% CI: 0.963–0.989), 0.961 (95% CI: 0.956–0.989), and 0.996 (95% CI: 0.957–0.997), respectively.Conclusions: The residual network-based algorithm can effectively automatically diagnose AMI and MI location from 12-lead ECGs.
Association Between Prospective Registration and Quality of Systematic Reviews in Type 2 Diabetes Mellitus: A Meta-epidemiological Study
Authors: Zheng Qiuyi , Lai Fenghua , Li Bin , Xu Jia , Long Jianyan , Peng Sui , Li Yanbing , Liu Yihao , Xiao Haipeng 
Published: June 2021

Background: We sought to investigate the methodological and reporting quality of published systematic reviews describing randomized controlled trials in type 2 diabetes mellitus and analyze their association with status of protocol registration.Methods: We searched the PubMed database and identified non-Cochrane systematic reviews, with or without meta-analysis, reporting on type 2 diabetes mellitus and published between 2005 and 2018. We then randomly selected 20% of these reviews in each year, and performed methodological and reporting quality assessment using the Assessment of Multiple Systematic Review 2 (AMSTAR-2) checklist and Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. We also conducted regression analyses to explore the association between characteristics of systematic reviews and AMSTAR-2 or PRISMA scores.Results: A total of 238 systematic reviews, including 33 registered and 205 non-registered articles, met the inclusion criteria and were subsequently reviewed. Analysis indicated an increase in both registered rates and quality of systematic reviews in type 2 diabetes mellitus over the recent years. With regards to methodological and reporting quality, we found higher scores in registered, relative to non-registered reviews (AMSTAR-2 mean score: 18.0 vs. 14.5, P = 0.000; PRISMA mean score: 20.4 vs. 17.6, P = 0.000). AMSTAR-2 and PRISMA scores were associated with registration status, country of the first author, and statistical results, whereas the proportion of discussing publication bias and reporting funding sources were &lt;40% for both registered and non-registered systematic reviews.Conclusions: Methodological and reporting quality of systematic reviews in type 2 diabetes mellitus indicates an improvement in the recent years. However, the overall quality remains low, necessitating further improvement. Future studies are expected to pay more attention to prospective registration, description of publication bias and reporting of funding sources.
Designing a Self-Perception Cognitive Questionnaire for Italian Multiple Sclerosis Patients (Sclerosi Multipla Autovalutazione Cognitiva, SMAC). A Preliminary Exploratory Pilot Study
Authors: Riccardi Alice , Ognibene Francesca , Mondini Sara , Nucci Massimo , Margoni Monica , Meglioranzi Ilaria , Carta Elisa , Zywicki Sofia , Miante Silvia , Perini Paola , Rinaldi Francesca , Puthenparampil Marco , Gallo Paolo 
Published: June 2021

Background: Although cognition in multiple sclerosis (MS) is assessed by means of several neuropsychological tests, only a few tools exist to investigate patients' perspectives on cognitive functioning.Objective: To develop a new questionnaire aimed at exploring patients' self-perception with respect to cognition in Italian MS patients.Methods: A total of 120 relapsing-remitting MS (RRMS) patients and 120 matched healthy controls (HC) completed a 25-item questionnaire called the Sclerosi Multipla Autovalutazione Cognitiva (SMAC). The Symbol Digit Modalities Test (SDMT), the Delis-Kaplan Executive Function System Sorting Test (D-KEFS ST), the Beck Depression Inventory (BDI-II), and the Fatigue Scale (FSS) were also administered to the patients.Results: Significantly higher SMAC scores were displayed by RRMS patients compared with HC (30.1 ± 16.9 vs. 23.4 ± 10.4, p = 0.003). SMAC inversely correlated with SDMT (r = −0.31, p &lt; 0.001), D-KEFS ST FSC (r = −0.21, p = 0.017), D-KEFS ST FSD (r = −0.22, p = 0.015) and D-KEFS ST SR (r = −0.19, p = 0.035) and positively correlated with FSS (r = 0.42, p &lt; 0.001) and BDI-II (r = 0.59, p &lt; 0.001). Cronbach's alpha coefficient for the questionnaire was 0.94.Conclusion: Preliminary findings suggest that SMAC is a promising patient-reported outcome to be included in MS neuropsychological evaluation and thus warrants being further tested and developed.
Saccades Matter: Reduced Need for Caloric Testing of Cochlear Implant Candidates by Joint Analysis of v-HIT Gain and Corrective Saccades
Authors: Fuentealba Bassaletti Constanza , van Esch Babette F. , Briaire Jeroen J. , van Benthem Peter Paul G. , Hensen Erik F. , Frijns Johan H. M. 
Published: June 2021

Objectives: Video head impulse test (v-HIT) is a quick, non-invasive and relatively cheap test to evaluate vestibular function compared to the caloric test. The latter is, however, needed to decide on the optimal side to perform cochlear implantation to avoid the risk on inducing a bilateral vestibular areflexia. This study evaluates the effectiveness of using the v-HIT to select cochlear implant (CI) candidates who require subsequent caloric testing before implantation, in that way reducing costs and patient burden at the same time.Study Design: Retrospective study using clinical data from 83 adult CI-candidates, between 2015 and 2020 at the Leiden University Medical Center.Materials and Methods: We used the v-HIT mean gain, MinGain_LR, the gain asymmetry (GA) and a newly defined parameter, MGS (Minimal Gain &amp; Saccades) as different models to detect the group of patients that would need the caloric test to decide on the ear of implantation. The continuous model MGS was defined as the MinGain_LR, except for the cases with normal gain (both sides ≥0.8) where no corrective saccades were present. In the latter case MGS was defined to be 1.0 (the ideal gain value).Results: The receiver operating characteristics curve showed a very good diagnostic accuracy with and area under the curve (AUC) of 0.81 for the model MGS. The v-HIT mean gain, the minimal gain and GA had a lower diagnostic capacity with an AUC of 0.70, 0.72, and 0.73, respectively. Using MGS, caloric testing could be avoided in 38 cases (a reduction of 46%), with a test sensitivity of 0.9 (i.e., missing 3 of 28 cases).Conclusions: The newly developed model MGS balances the sensitivity and specificity of the v-HIT better than the more commonly evaluated parameters such as mean gain, MinGain_LR and GA. Therefore, taking the presence of corrective saccades into account in the evaluation of the v-HIT gain can considerably reduce the proportion of CI-candidates requiring additional caloric testing.
Brain Energy Metabolism in Two States of Mind Measured by Phosphorous Magnetic Resonance Spectroscopy
Authors: Galijašević Malik , Steiger Ruth , Regodić Milovan , Waibel Michaela , Sommer Patrick Julian David , Grams Astrid Ellen , Singewald Nicolas , Gizewski Elke Ruth 
Published: June 2021

Introduction:Various functional neuroimaging studies help to better understand the changes in brain activity during meditation. The purpose of this study was to investigate how brain energy metabolism changes during focused attention meditation (FAM) state, measured by phosphorous magnetic resonance spectroscopy (31P-MRS).Methods:31P-MRS imaging was carried out in 27 participants after 7 weeks of FAM training. Metabolite ratios and the absolute values of metabolites were assessed after meditation training in two MRI measurements, by comparing effects in a FAM state with those in a distinct focused attention awake state during a backwards counting task.Results:The results showed decreased phosphocreatine/ATP (PCr/ATP), PCr/ inorganic phosphate (Pi), and intracellular pH values in the entire brain, but especially in basal ganglia, frontal lobes, and occipital lobes, and increased Pi/ATP ratio, cerebral Mg, and Pi absolute values were found in the same areas during FAM compared to the control focused attention awake state.Conclusions:Changes in the temporal areas and basal ganglia may be interpreted as a higher energetic state induced by meditation, whereas the frontal and occipital areas showed changes that may be related to a down-regulation in ATP turnover, energy state, and oxidative capacity.
Autonomic Nervous System Function in Anorexia Nervosa: A Systematic Review
Authors: Jenkins Zoe M. , Eikelis Nina , Phillipou Andrea , Castle David J. , Wilding Helen E. , Lambert Elisabeth A. 
Published: June 2021

Background:Autonomic nervous system (ANS) dysfunction has been suggested to contribute to the high prevalence of cardiovascular complications in individuals with anorexia nervosa (AN), yet has not been thoroughly investigated. The current review aimed to synthesize the evidence of basal ANS function in individuals with a current diagnosis of AN and those with a previous diagnosis who had achieved weight restoration, as compared to controls.Methods:A systematic review of nine databases was conducted and studies that were published in a peer-review journal, in English, that included at least one assessment of ANS function in individuals with a current or previous diagnosis of AN were selected. Forty-six studies were included with a total of 811 participants with a current diagnosis of AN and 123 participants with a previous diagnosis of AN.Results:ANS function was assessed through heart rate variability (n= 27), orthostatic challenge, blood pressure variability or baroreflex sensitivity (n= 11), adrenergic activity (n= 14), skin conductance level (n= 4), and pupillometry (n= 1). Individuals with AN demonstrated increased parasympathetic activity and decreased sympathetic activity, suggestive of autonomic dysregulation. Following weight restoration, autonomic function trended toward, or was equivalent to, control levels.Discussion:Autonomic dysregulation is indicated through a range of assessments in individuals with AN. Future investigations should utilize a variety of assessments together in order to conclusively establish the nature of autonomic dysfunction in AN, and following extended weight restoration. Moreover, investigation into the co-occurrence of ANS function and cardiovascular risk is required.
Whole-Genome Methylation Study of Congenital Lung Malformations in Children
Authors: Patrizi Sara , Pederiva Federica , d’Adamo Adamo Pio 
Published: June 2021

Background and ObjectivesThe treatment of asymptomatic patients with congenital pulmonary malformations (CPMs) remains controversial, partially because the relationship between congenital lung malformations and malignancy is still undefined. Change in methylation pattern is a crucial event in human cancer, including lung cancer. We therefore studied all differentially methylated regions (DMRs) in a series of CPMs in an attempt to find methylation anomalies in genes already described in association with malignancy.MethodsThe DNA extracted from resected congenital lung malformations and control lung tissue was screened using Illumina MethylationEPIC arrays. Comparisons between the group of malformed samples or the malformed samples of same histology or each malformed sample and the controls and between a pleuropulmonary blastoma (PPB) and controls were performed. Moreover, each malformed sample was pairwise compared with its respective control. All differentially methylated regions (DMRs) with an adjusted p-value &lt;0,05 were studied.ResultsEvery comparison highlighted a number of DMRs closed to genes involved either in cell proliferation or in embryonic development or included in the Cancer Gene Census. Their abnormal methylation had been already described in lung tumors.ConclusionsMethylation anomalies already described in lung tumors and also shared by the PPB were found in congenital lung malformations, regardless the histology. The presence of methylation abnormalities is suggestive of a correlation between congenital lung malformations and some step of malignant transformation.