bluuebunny/crossref_metadata_2025_split huggingface dataset:
Internal surface roughness measurement of metal additively manufactured samples via x-ray CT: the influence of surrounding material thickness
Authors: Lifton Joseph John , Liu Yuchan , Tan Zheng Jie , Mutiargo Bisma , Goh Xue Qi , Malcolm Andrew Alexander 
Published: June 2021

Abstract
X-ray computed tomography (XCT) can be used to measure the internal and external surfaces of an object non-destructively and with micron-level spatial resolution. XCT is therefore an appealing method for measuring and characterising the internal surface roughness of additively manufactured parts that cannot be accessed by traditional tactile and optical surface roughness instruments. In this work, an additively manufactured aluminium spherical surface roughness sample is designed, fabricated and its surface roughness measured via a focus variation microscope, the sample is then XCT scanned when embedded in varying thicknesses of surrounding material. A quantitative and qualitative comparison between the optical and XCT surface roughness measurements is made; the results show that the Sa of the XCT-based surface roughness measurements increases as a function of surrounding material thickness.
Comparison between patient-specific deep brain stimulation simulations and commercial system SureTune3
Authors: Johansson Johannes D , Zsigmond Peter 
Published: June 2021

Abstract

Objective. Software to visualize estimated volume of tissue activated (VTA) in deep brain stimulation assuming a homogeneous tissue surrounding such as SureTune3 has recently become available for clinical use. The objective of this study is to compare SureTune3 with homogeneous and heterogeneous patient-specific finite element method (FEM) simulations of the VTA to elucidate how well they coincide in their estimates. Approach. FEM simulations of the VTA were performed in COMSOL Multiphysics and compared with VTA from SureTune3 with variation of voltage and current amplitude, pulse width, axon diameter, number of active contacts, and surrounding homogeneous grey or white matter. Patient-specific simulations with heterogeneous tissue were also performed. Main results. The VTAs corresponded well for voltage control in homogeneous tissue, though with the smallest VTAs being slightly larger in SureTune3 and the largest VTAs being slightly larger in the FEM simulations. In current control, FEM estimated larger VTAs in white matter and smaller VTAs in grey matter compared to SureTune3 as grey matter has higher electric conductivity than white matter and requires less voltage to reach the same current. The VTAs also corresponded well in the patient-specific cases except for one case with a cyst of highly conductive cerebrospinal fluid (CSF) near the active contacts. Significance. The VTA estimates without taking the surrounding tissue into account in SureTune3 are in good agreement with patient-specific FEM simulations when using voltage control in the absence of CSF-filled cyst. In current control or when CSF is present near the active contacts, the tissue characteristics are important for the VTA and needs consideration. Clinical. trial ethical approval: Local ethics committee at Linköping University (2012/434-31).
Spatial variation in the intensity of interactions via heterospecific pollen transfer may contribute to local and global patterns of plant diversity
Authors: Arceo-Gómez Gerardo 
Published: June 2021

Abstract

Background
Studies that aim to understand the processes that generate and organize plant diversity in nature have a long history in ecology. Among these, the study of plant–plant interactions that take place indirectly via pollinator choice and floral visitation has been paramount. Current evidence, however, indicates that plants can interact more directly via heterospecific pollen (HP) transfer and that these interactions are ubiquitous and can have strong fitness effects. The intensity of HP interactions can also vary spatially, with important implications for floral evolution and community assembly.

Scope
Interest in understanding the role of heterospecific pollen transfer in the diversification and organization of plant communities is rapidly rising. The existence of spatial variation in the intensity of species interactions and their role in shaping patterns of diversity is also well recognized. However, after 40 years of research, the importance of spatial variation in HP transfer intensity and effects remains poorly known, and thus we have ignored its potential in shaping patterns of diversity at local and global scales. Here, I develop a conceptual framework and summarize existing evidence for the ecological and evolutionary consequences of spatial variation in HP transfer interactions and outline future directions in this field.

Conclusions
The drivers of variation in HP transfer discussed here illustrate the high potential for geographic variation in HP intensity and its effects, as well as in the evolutionary responses to HP receipt. So far, the study of pollinator-mediated plant–plant interactions has been almost entirely dominated by studies of pre-pollination interactions even though their outcomes can be influenced by plant–plant interactions that take place on the stigma. It is hence critical that we fully evaluate the consequences and context-dependency of HP transfer interactions in order to gain a more complete understanding of the role that plant–pollinator interactions play in generating and organizing plant biodiversity.
Effects of noninherited ancestral genotypes on offspring phenotypes†
Authors: Cullen Sean M , Hassan Nora , Smith-Raska Matthew 
Published: June 2021

Abstract
It is well established that environmental exposures can modify the profile of heritable factors in an individual’s germ cells, ultimately affecting the inheritance of phenotypes in descendants. Similar to exposures, an ancestor’s genotype can also affect the inheritance of phenotypes across generations, sometimes in offspring who do not inherit the genetic aberration. This can occur via a variety of prenatal, in utero, or postnatal mechanisms. In this review, we discuss the evidence for this process in mammals, with a focus on examples that are potentially mediated through the germline, while also considering alternate routes of inheritance. Noninherited ancestral genotypes may influence descendant’s disease risk to a much greater extent than currently appreciated, and focused evaluation of this phenomenon may reveal novel mechanisms of inheritance.
Bayesian multiregional clinical trials using model averaging
Authors: Bean Nathan W , Ibrahim Joseph G , Psioda Matthew A 
Published: June 2021

SummaryMultiregional clinical trials (MRCTs) provide the benefit of more rapidly introducing drugs to the global market; however, small regional sample sizes can lead to poor estimation quality of region-specific effects when using current statistical methods. With the publication of the International Conference for Harmonisation E17 guideline in 2017, the MRCT design is recognized as a viable strategy that can be accepted by regional regulatory authorities, necessitating new statistical methods that improve the quality of region-specific inference. In this article, we develop a novel methodology for estimating region-specific and global treatment effects for MRCTs using Bayesian model averaging. This approach can be used for trials that compare two treatment groups with respect to a continuous outcome, and it allows for the incorporation of patient characteristics through the inclusion of covariates. We propose an approach that uses posterior model probabilities to quantify evidence in favor of consistency of treatment effects across all regions, and this metric can be used by regulatory authorities for drug approval. We show through simulations that the proposed modeling approach results in lower MSE than a fixed-effects linear regression model and better control of type I error rates than a Bayesian hierarchical model.
Permanent stoma rates after anterior resection for rectal cancer: risk prediction scoring using preoperative variables
Authors: Back E , Häggström J , Holmgren K , Haapamäki M M , Matthiessen P , Rutegård J , Rutegård M 
Published: June 2021

Abstract

Background
A permanent stoma after anterior resection for rectal cancer is common. Preoperative counselling could be improved by providing individualized accurate prediction modelling.

Methods
Patients who underwent anterior resection between 2007 and 2015 were identified from the Swedish Colorectal Cancer Registry. National Patient Registry data were added to determine presence of a stoma 2 years after surgery. A training set based on the years 2007–2013 was employed in an ensemble of prediction models. Judged by the area under the receiving operating characteristic curve (AUROC), data from the years 2014–2015 were used to evaluate the predictive ability of all models. The best performing model was subsequently implemented in typical clinical scenarios and in an online calculator to predict the permanent stoma risk.

Results
Patients in the training set (n = 3512) and the test set (n = 1136) had similar permanent stoma rates (13.6 and 15.2 per cent). The logistic regression model with a forward/backward procedure was the most parsimonious among several similarly performing models (AUROC 0.67, 95 per cent c.i. 0.63 to 0.72). Key predictors included co-morbidity, local tumour category, presence of metastasis, neoadjuvant therapy, defunctioning stoma use, tumour height, and hospital volume; the interaction between age and metastasis was also predictive.

Conclusion
Using routinely available preoperative data, the stoma outcome at 2 years after anterior resection for rectal cancer can be predicted fairly accurately.
Flexible sodium-ion batteries using electrodes from Samanea saman tree leaf-derived carbon quantum dots decorated with SnO2 and NaVO3
Authors: Thangaraj Baskar , Chuangchote Surawut , Wongyao Nutthapon , Solomon Pravin Raj , Roongraung Kamonchanok , Chaiworn Wachira , Surareungchai Werasak 
Published: June 2021

Abstract
Carbonaceous materials with large interlayer spacing and disordered structure are considered suitable as electrodes in sodium-ion batteries so as to overcome the problem encountered in conventional electrodes. In this study, carbon quantum dots (CQDs) decorated with SnO2 and NaVO3 are used as electrodes in the fabrication of flexible Na-ion batteries. CQDs are prepared from dead leaves of the Samanea saman tree through alkaline-peroxide treatment and hydrothermal carbonization. As-prepared CQDs exhibit a quantum yield of 21.03% at an excitation wavelength of 360 nm. Various separators such as indium-doped tin oxide/polyoxyethylene tridecyl ether (ITO/PTE), rice paper (RP), silicone with three big holes (SIL BH), silicone with many small holes (SIL SH) and cellulose paper (CP) have been tried in flexible Na-ion batteries. SIL SH achieved higher specific capacitance (881 F g–1) than other separators due to the function of many small holes on the surface of the silicone. The SIL SH separator delivered higher discharge capacities of 141 and 114 mC g–1 at 1.5 and 2.5 V than SIL BH. The RP separator delivered specific discharge capacities of 1087 and 347 mC g–1 in the 1st and 50th cycles, respectively, at 1 V. The RP separator delivered a high initial specific discharge capacity of 698 mC g–1 at 2 V and maintained a good discharge capacity of 222 mC g–1 in the 50th cycle. As compared to RP, SIL SH delivered high specific discharge capacity of 4246 in 1st cycle at 2 V but maintained a capacity of 71 mC g–1 in the 50th cycle. This study reveals the scope of developing flexible Na-ion batteries with high capacity and cyclability using carbonaceous materials derived from the leaves of the S. saman tree.
Carbon quantum dots (CQDs)-decorated with SnO2 and NaVO3 are used as electrodes in the fabrication of flexible Na-ion batteries. CQDs exhibit a quantum yield of 21% at the excitation wavelength of 360 nm. The electrochemical performances of fabricated batteries are investigated by cyclic voltammetry.
Local anesthetics for the Nephrologist
Authors: Uppal Nupur N , Jhaveri Mital , Hong Susana , Shore-Lesserson Linda , Jhaveri Kenar D , Izzedine Hassan 
Published: June 2021

Abstract
Several specialists in medicine use local anesthetics. In patients with kidney disease, these agents are used during catheter insertions for hemodialysis and peritoneal dialysis, arteriovenous fistula and graft procedures, kidney transplantation, parathyroidectomy, kidney biopsies, and dental and skin procedures. Patients on chronic hemodialysis use a topical application prior to use of needles for arteriovenous fistula cannulation before starting dialysis. They are also used to manage acute and chronic pain conditions, in regional nerve blockade and in multi-modal enhanced recovery protocols. Despite their frequent use by both physicians and patients, data on the use of local anesthetics in patients with kidney impairment are not well reported. This review will summarize the use of local anesthetics in chronic kidney disease, describe their pharmacology and the impact of lower estimated glomerular filtration rate on their pharmacokinetics, and suggest dose regulation in those with kidney dysfunction.
Association between computed tomography-derived tricuspid annular dimensions and prognosis: insights from whole-beat computed tomography assessment
Authors: Hirasawa Kensuke , Fortuni Federico , van Rosendael Philippe J , Ajmone Marsan Nina , Bax Jeroen J , Delgado Victoria 
Published: June 2021

Abstract

Aims
Tricuspid regurgitation (TR) has been associated with outcome in patients treated with transcatheter aortic valve implantation (TAVI). Tricuspid annulus (TA) dimensions are associated with TR. However, the TA is highly dynamic during the cardiac cycle, and the interaction between the TA dimensions, TR, and patient prognosis has never been evaluated. This study aimed to characterize the dynamics of the TA along with the cardiac cycle and its association with prognosis in patients undergoing TAVI.

Methods and results
Patients with severe aortic stenosis who underwent whole-beat computed tomography (n = 393, mean age 80 ± 7 years, 53% male) were included. The ratio between anterior-posterior (AP) and septal-lateral (SL) diameter of the TA was calculated at end-systole (ES), mid-diastole (MD), and end-diastole (ED) to characterize the TA shape throughout the cardiac cycle. The primary endpoint was all-cause mortality. During a median follow-up of 3.6 (1.7–5.5) years, 146 patients died. While all the TA parameters at ES and MD were not associated with all-cause mortality, a low AP/SL ratio at ED (more circular geometry) was independently related with all-cause mortality (hazard ratio: 4.717, 95% confidence interval: 1.481–15.152; P = 0.009). In addition, a more circular TA shape at ED (AP/SL ratio &lt; 1.20) was also associated with more right atrial and ventricular dilation, more frequently significant TR, and a higher prevalence of atrial fibrillation.

Conclusion
Circular remodelling of the TA shape at ED is associated with more right atrial and ventricular dilation, and a higher long-term mortality after TAVI. The evaluation of the TA shape at ED may be a useful parameter in the risk stratification of patients undergoing TAVI.
Management of rheumatic aortic valve disease using the Ozaki procedure with autologous pericardium: a case report
Authors: Asif Ashar , Benedetto Umberto , Ofoe Victor , Caputo Massimo 
Published: June 2021

Abstract

Background
Rheumatic valve disease (RVD) is the most common cause of cardiovascular death in low-middle income nations. Surgical aortic valve (AV) interventions for RVD, especially in children, have proven problematic with graft failure, relapse, and poor compliance with anticoagulation. A novel technique involving neocuspidization of the aortic annulus using autologous pericardium to construct new AV leaflets (the Ozaki procedure) has shown promising outcomes in children with congenital AV disease; however, there are no previous recorded cases using this technique in children with RVD.

Case summary
We present the case of a 15-year-old male presenting with exertional angina and dyspnoea with a background of previous rheumatic fever. Echocardiography had shown a regurgitant tricuspid AV, left ventricular dilatation with mitral valve leaflet tethering. The patient underwent the Ozaki procedure for his AV regurgitation and was discharged following an uneventful post-operative recovery. The patient had full resolution of symptoms following the procedure and remains well 3 years following his operation.

Discussion
This case highlights that good outcomes with the Ozaki procedure in RVD are possible 3-years post-operatively and should prompt future studies to evaluate the procedure as a surgical option for paediatric patients in this clinical context. Additionally, the Ozaki procedure may also provide a cost-effective surgical technique requiring minimal additional operative resources and reduced follow-up demand, which would be critical in low-resource clinical settings where RVD is prevalent.
The role of signal production and transduction in induced resistance of harvested fruits and vegetables
Authors: Wang Bin , Bi Yang 
Published: June 2021

Abstract
Postharvest diseases are the primary reason causing postharvest loss of fruits and vegetables. Although fungicides show an effective way to control postharvest diseases, the use of fungicides is gradually being restricted due to safety, environmental pollution, and resistance development in the pathogen. Induced resistance is a new strategy to control postharvest diseases by eliciting immune activity in fruits and vegetables with exogenous physical, chemical, and biological elicitors. After being stimulated by elicitors, fruits and vegetables respond immediately against pathogens. This process is actually a continuous signal transduction, including the generation, transduction, and interaction of signal molecules. Each step of response can lead to corresponding physiological functions, and ultimately induce disease resistance by upregulating the expression of disease resistance genes and activating a variety of metabolic pathways. Signal molecules not only mediate defense response alone, but also interact with other signal transduction pathways to regulate the disease resistance response. Among various signal molecules, the second messenger (reactive oxygen species, nitric oxide, calcium ions) and plant hormones (salicylic acid, jasmonic acid, ethylene, and abscisic acid) play an important role in induced resistance. This article summarizes and reviews the research progress of induced resistance in recent years, and expounds the role of the above-mentioned signal molecules in induced resistance of harvested fruits and vegetables, and prospects for future research.
Effect of raspberry extract on wound healing
Authors: Lu Wenjing , Xu Meng , Yuan Youwei , Zhang Xuemei , Tan Jianxin , He Junping , Tian Yiling 
Published: June 2021

Abstract
The main purpose of this study was to investigate the effect of raspberry extract on wound healing and compare it with that of ellagic acid. The elimination of excess free radicals was the key to preventing wound inflammation; cellular antioxidation activity was evaluated using an oxidative stress damage cell model. Cell proliferation ability was measured using the WST-1 assay, and the migration capacity was determined using the wound scratch assay. A mouse wound model was used to verify the effect of raspberry extract on wound healing. The cellular antioxidant activity of the extract ((50.31±3.17) μg/mL) was slightly lower than that of ellagic acid ((44.59±2.38) μg/mL). The results of a cell proliferation assay showed that both raspberry extract and ellagic acid at 5 μg/mL could significantly (P&lt;0.01) promote the proliferation of HaCaT cells. After culturing for 24 h and 48 h, the cell healing rates of the extract were (41.11±0.38) per cent and (68.88±2.51) per cent, respectively, whereas the corresponding rates of ellagic acid were (39.01±2.40) per cent and (70.33±0.89) per cent; hence, there were no significant differences between them (P&gt;0.05). The wound areas of mice fed low, medium, and high doses of raspberry extract for 14 days were 1.66, 1.41, and 1.24 mm2, respectively, which were significantly lower than that of the blank control group, 2.18 mm2 (P&lt;0.05). These findings indicate that raspberry extract and ellagic acid exhibit similar antioxidant capacities and equivalent cell proliferation-promoting capabilities. In the mouse test, raspberry extract effectively promoted a reduction in wound area. This work demonstrates the potential of raspberry extract in wound healing, suggesting a promising application of raspberry resources in the fields of functional foods, cosmetics, and medicine.
Future magnitude 7.5 earthquake offshore Martinique: spotlight on the main source features controlling ground motion prediction
Authors: Oral Elif , Satriano Claudio 
Published: June 2021

SUMMARY
The eastern offshore of Martinique is one of the active areas of the Lesser Antilles Subduction Zone (LASZ). Although its seismicity is moderate compared to other subduction zones, LASZ is capable of generating a M 7+ interplate earthquake and recent studies and historical events, such as the M 8 1839 and M 7–7.5 1946 earthquakes, confirm this possibility. Given the high risk that Martinique can face in case of unpreparedness for such a M 7+ earthquake, and the lack of a regional seismic hazard study, we investigated through numerical modelling how ground motion can vary for a hypothetical Mw 7.5 interplate earthquake. Our main objective is to highlight the major factors related to earthquake source that can cause the highest variation in ground motion at four broad-band seismic stations across Martinique. For this purpose, we generated 320 rupture scenarios through a fractal kinematic source model, by varying rupture directivity, source dimension, slip distribution. We computed the broad-band ground motion (0.5–25 Hz) by convolution of source–time functions with empirical Green’s functions (EGFs), that we selected from the analysis of moderate events (M 4–4.5) recorded in the area of interest since 2016 by the West Indies network. We found that the fault geometry and the spatial extension of the largest slip patch are the most influential factors on ground motion. The significance of the variation of the predicted ground motion with respect to ground motion prediction equations (GMPEs) depends on the evaluated frequency of ground motion and on the station. Moreover, we concluded that the EGF selection can be another significant factor controlling the modelled ground motion depending on station. Our results provide a new insight for the seismic source impact on ground motion across Martinique and can guide future blind seismic hazard assessment studies in different regions.
Artificial intelligence in the fertility clinic: status, pitfalls and possibilities
Authors: Riegler M A , Stensen M H , Witczak O , Andersen J M , Hicks S A , Hammer H L , Delbarre E , Halvorsen P , Yazidi A , Holst N , Haugen T B 
Published: June 2021

ABSTRACT
In recent years, the amount of data produced in the field of ART has increased exponentially. The diversity of data is large, ranging from videos to tabular data. At the same time, artificial intelligence (AI) is progressively used in medical practice and may become a promising tool to improve success rates with ART. AI models may compensate for the lack of objectivity in several critical procedures in fertility clinics, especially embryo and sperm assessments. Various models have been developed, and even though several of them show promising performance, there are still many challenges to overcome. In this review, we present recent research on AI in the context of ART. We discuss the strengths and weaknesses of the presented methods, especially regarding clinical relevance. We also address the pitfalls hampering successful use of AI in the clinic and discuss future possibilities and important aspects to make AI truly useful for ART.