bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of the heat transfer coefficient of a rotary film evaporator with a heating film-forming element
Authors: Zahorulko Andrii , Zagorulko Aleksey , Cherevko Oleksander , Dromenko Olena , Solomon Alla , Yakobchuk Roman , Bondarenko Oksana , Nozdrina Nataliia 
Published: December 2021

A model of a rotary film evaporator with a film-forming element with a reflective heated surface has been developed. This will allow stabilizing the hydraulic movement of the cut wave flow due to the reflective surface of the geometric shape for the forced direction of the cut raw material to the heating surface. Autonomous heating of the reflective surface additionally provides a temperature effect in the conditions of movement of particles of raw materials after cutting.
The analysis of the experimental and theoretical parameters of heat transfer made it possible to substantiate the criterion equation for determining the heat transfer coefficient of an evaporator with the proposed film-forming element and a reflective heated surface for calculating the coefficient from the working surface to the raw material. The resulting equation takes into account the influence of the vertical component of the motion of the raw material film, centrifugal movement during the rotation of the film-forming element, mixing of the boiling film of the raw material with steam bubbles, and the geometric characteristics of the film-forming blade on the hydrodynamic flow of the raw material. The calculation of the rotary-film evaporator was carried out using the criterion equation and the obtained useful heat exchange surface – 0.75 m2. The specific metal consumption in a rotary film evaporator with a film-forming element having a reflective surface is 57 kg/m2, compared to the vacuum evaporator traditionally used in canning industries (410 kg/m2), which is 7.1 times less. The duration of the temperature effect on the raw material is also reduced: a rotary film evaporator – 200 s and 3600 s in a traditional apparatus. The data obtained will be useful for the design of rotary-film devices of different geometric parameters using articulated blades with a reflective plate.
Devising an individually oriented method for selection of scientific activity subjects for implementing scientific projects based on scientometric analysis
Authors: Xu Huilin , Kuchansky Alexander , Gladka Myroslava 
Published: December 2021

The main factors influencing the choice of individual subjects of the scientific activity or potential partners and executors for scientific and educational projects were analyzed. The specific features of choosing project executors of different categories were indicated. The functional responsibilities of project participants in accordance with the project structure were described.
The individually oriented method for choosing subjects of scientific activity as executors of scientific and educational projects was developed, taking into account the productivity of their scientific activities in the past and considering the structure of projects. To determine the merits of the subjects of scientific activity, which are included in the relevant scientific subject spaces, it is necessary to apply the procedure of their productivity assessment. In addition, it is necessary to predict a change in productivity in the future based on retrospective data for this subject. Next, it is required to solve the multi-criteria problem of the choice among the subjects of scientific activity who are quite productive in the opinion of the project manager. The use of the developed method reduces the subjective impact on making a decision regarding the choice of project executors. This is due to the fact that they are chosen by automated calculation of scientometric indicators of subjects, guided only by open sources of information.
The individually oriented method for the selection of subjects of scientific activity was verified on the example of the formation of three applications of research projects. As a result, the average percentage of scientists who meet the requirements of project managers for each scientific subject space was about 46.55 %. The percentage of those involved in the project from those who were selected is about 24.07 %. The probability of cooperation is higher among those who have an average H-index.
Comparing the efficiency of applying yeast of different generations in high gravity brewing
Authors: Kosiv Ruslana 
Published: December 2021

When fermenting beer, in addition to the formation of basic, secondary, and by-products, which largely determine the taste and aroma of the beverage, yeast is accumulated. Such yeasts can be reused in subsequent serial repitching, which allows cost savings compared to yeast cultivated for each fermentation.
This paper investigates the influence of yeast generation on the progress of the wort fermentation process and the quality of beer obtained, specifically in high gravity brewing.
It was established that the increase in the number of yeast generation in the range from the first to the fourth generation causes a slight acceleration of the fermentation process of high-gravity wort, while at higher values of the fermentation generation number it slows down. Yeasts secreted after six or four serial wort fermentations with a gravity of 15 °P/18 °P, respectively, have a good physiological state and can be reused. The yeast generation number does not significantly affect ethanol content and sensory beer quality indicators. However, the use of yeast of the seventh and eighth generation causes a slight increase in the pH and color of high gravity beer, the appearance in the aroma of noticeable extraneous shades ‒ yeast tone, tone of young beer.
As wort gravity increases, the number of yeast re-use cycles decreases, which is a consequence of the influence of various stress factors, specifically high osmotic pressure, and increased ethanol levels. Therefore, for the fermentation of wort with a gravity of 15 °P, it is recommended to use yeast up to five generations, for 18 °P wort ‒ to four generations. To obtain beer with appropriate physicochemical parameters and high sensory evaluation in high gravity brewing technology, it is advisable to ferment wort with a gravity of 15 °P with yeast for up to five generations.
Analysis of the main factors affecting mass production in the plastic molding process by using the finite element method
Authors: Magid Hani Mizhir , Dabis Badr Kamoon , Abed alabas Siba Mohammad 
Published: December 2021

Plastic injection molding is widely used in many industrial applications. Plastic products are mostly used as disposable parts or as portable parts for fast replacements in many devices and machines. However, mass production is always adopted as an ideal method to cover the huge demands and customers’ needs. The problems of warpage due to thermal stresses, non-uniform pressure distribution around cavities, shrinkage, sticking and overall products quality are some of the important challenges. The main objective of this work is to analyze the stress distribution around the cavities during the molding and demolding to avoid their effects on the product quality. Moreover, diagnosing the critical pressure points around and overall the cavity projection area, which is subjected to high pressure will help to determine the optimum pressure distribution and ensure filling all cavities at the same time, which is another significant objective. Computer-aided design (CAD) and CATIA V5R20 are adopted for design and modeling procedures. The computer-aided engineering (CAE) commercial software ABAQUS 6141 has been dedicated as finite element simulation packages for the analysis of this process. Simulation results show that stress distribution over the cavities depends on both pressure and temperature gradient over the contact surfaces and can be considered as the main affecting factor. The acceptable ranges of the cavity stresses were determined according to the following values: the cavity and core region temperature of 55–65 °C, filling time of 10–20 s, ejection pressure 0.85 % of injection pressure, and holding time of 10–15 s. Also, theoretical results reveal that the uniform pressure and temperature distribution can be controlled by adjusting the cavities layout, runner, and gate size. Moreover, the simulation process shows that it is possible to facilitate and identify many difficulties during the process and modify the prototype to evaluate the overall manufacturability before further investing in tooling. Furthermore, it is also concluded that tooling iterations will be minimized according to the design of the selected process
Screening study of the antihyperglycemic action of new solid quercetin dispersions
Authors: Ruban Olena , Kononenko Nadiia , Kovalevska Inna , Chikitkina Valentyna 
Published: December 2021

The aim – to screen new solid dispersions of quercetin for the presence of antihyperglycemic action and to identify the most active substances that are promising for the creation of antidiabetic drugs.
Materials and methods. The object of the study was 4 new solid dispersions of quercetin, developed at the National University of Pharmacy. Solid dispersions of quercetin were prepared by the liquid-phase method; hydroxypropyl methylcellulose (HPMC) or polyvinylpyrrolidone (PVP) in ratios of 1:1 and 1:2 were used as a carrier. The antihyperglycemic effect of the studied substances at a dose of 50 mg / kg was assessed in rats by the ability to lower blood glucose levels after carbohydrate loading in a model of impaired glucose tolerance induced by dexamethasone and in experimental type 2 diabetes mellitus induced by dexamethasone.
Results. It was found that with impaired glucose tolerance, a solid dispersion of quercetin with HPMC (1:1) showed a pronounced antihyperglycemic effect – the glucose level 30 minutes after glucose load significantly decreased by 28 % and did not differ from the action of metformin, which was confirmed by the value of the area under glycemic crooked. When solid dispersions with PVP (1:1 and 1:2) were used, the antihyperglycemic effect was less pronounced. In a model of type 2 diabetes mellitus, a significant antihyperglycemic effect was found only in a solid dispersion of quercetin with HPMC (1:1) at the metformin level, which indicates an increase in the solubility and absorption of quercetin.
Conclusions. A pronounced antihyperglycemic effect at the metformin level was found in a solid dispersion of quercetin with HPMC in a 1:1 ratio with impaired glucose tolerance and type 2 diabetes mellitus. It has been proven that a solid dispersion of quercetin with HPMC is a promising substance for creating a monocomponent drug or for inclusion in a new antidiabetic combined drug
Results of public assessment of influence factors on the formation of the brand of the institution of higher education in the pharmaceutical direction
Authors: Kotvitska Alla , Volkova Alina , Yakovlieva Olena 
Published: December 2021

The aim of the article is to study the attitude of target audiences to the brand of a higher education institution, taking into account the specifics of the educational services provided to them and the specifics of the educational services market.
Methods of the research: theoretical (analysis and synthesis of scientific literature and normative sources, generalization, analytical, comparative and logical), empirical (descriptions, comparison, questionnaires, mathematical and statistical).
Materials: questionnaires of respondents, which were applicants, students, alumni and employees of NUPh.
Results of the research. According to students, the most significant factors are positive reviews about HEI (14 % of respondents), the quality of educational services and the involvement of well-known scientists and practitioners (12 % each), the presence of scientific schools, traditions and the active participation of the institution in public life (11 % each factor). For applicants, an important place is occupied by the state status of a higher education institution, positive reviews about it and high quality of educational services (13 % for each factor). The advantages that graduates of the prestigious HEI have after graduation are a high level of theoretical knowledge (89 % of respondents) and practical skills (85 %), a high level of competitiveness in the labor market (81 %). Among the main directions for the development and improvement of the educational brand, the interviewed NUPh employees noted the constant improvement of the quality of educational services (91 % of the respondents), the intensification of international cooperation (86 %), the active involvement of practitioners and scientists in the scientific, volunteer and cultural life of the institution (79 %).
Conclusions. It has been proven that an important component of the brand of a higher education institution is an educational service; image of educational services; the benefits to be provided by the brand owner to consumers of educational services. The most significant factors of popularity and positive attitude towards NUPh and the advantages received by graduates after graduation have been established. A conclusion was made about the high level of corporate culture in HEI, the important elements of which are the presence of the NUPh development strategy, the introduction of effective management technologies and the creation of conditions for the self-realization of employees
Peculiarities of the nostrification of higher education diplomas
Authors: Kovalenko Serhii 
Published: December 2021

This article examines the problems of nostrification of foreign diplomas in Ukraine and the recognition of educational programmes, taken by graduates of foreign universities. Ukraine today is a wide market of professions, where our citizens with foreign diplomas and foreigners, who were educated at home, find jobs. The state is also guided by the educational process, which takes place in European countries and has its own characteristics and traditions. Work on universalization of education should have a positive impact on faster and better implementation of programmes of exchange of scientific and pedagogical experience between countries, academic mobility of students, postgraduates, teachers, etc. The article also mentions the traditional exchange of students and professors, the exchange of scientific achievements between universities in different countries, building mutually beneficial partnerships, which is why Ukrainian universities have to focus on the European labour market.
The article also discusses the peculiarities of the document flow for nostrification of diplomas, lists the main documents and reveals the problems, associated with their processing. The research problem has an interdisciplinary status, because it raises problems of documentation work, recognition of diplomas and problems, faced by graduates of foreign universities
The role of educational work in educational institutions in order to prevent the influence of harmful factors on the human body
Authors: Shlianina Allа , Shelyuk Iryna , Mulenko Svitlana , Shemet Olena 
Published: December 2021

The growing number of allergic diseases among people is a global problem. The article considers the role of educational work among students as an important component of knowledge formation about the causes of allergic diseases, prevention methods and maintaining a healthy lifestyle. It is established, that this problem is relevant in the world and requires the introduction of a system of measures to overcome it. The prevalence of allergic diseases has tripled in the last 10 years and to date allergies have reached pandemic proportions. The stages of allergic reactions and possible causes of allergic diseases (genetic, environmental, social) are indicated. The result of immunodeficiency as a result of allergies is the development of various complications or chronic diseases that can lead to disability and even death. The complex epidemiological situation in the world with a large increase in the number of allergic diseases requires constant monitoring to understand current trends. It is taken into account, that there are no statistical data on the level of prevalence of allergic diseases among the population of Ukraine, the study of epidemiological and preventive areas is relevant.
The problem of allergic manifestations was considered among the applicants for education of Zhytomyr Pharmaceutical Basic Vocational College. It has been found, that students of the college already have certain professional competencies: demonstrate knowledge and understanding of the concept of "allergy", the manifestation of allergies, treat the causes and ways of the disease, methods of diagnosing allergens, are informed about historical aspects of disease recognition. It has been proven, that issues, related to allergies, worry students because of the causes of their allergic reactions and diseases. It has been found, that students want to continue to receive and deepen modern knowledge on prevention, causes and types of allergic manifestations and ways to eliminate them. As a result of the analysis the actual questions of students and the necessary answer to them, teachers and specialists-allergists have been revealed.
The importance of information work among applicants for pharmaceutical education, which in their daily work will constantly use toxic substances, drugs and cosmetics that contain substances – allergens, has been traced.
Substantiation of the need to develop effective systems of actions for prevention, diagnosis and provision of treatment and prevention care to the population has been presented
Endüstrinin Estetik Arayışı: Minton, Hollins & Co. Üretimi İznik Desenli Sırlı Duvar Karoları
Authors: BİLİR Timur 
Published: December 2021

19. yüzyılın ilk yarısında İngiltere’de başlayan ve kısa sürede tüm Avrupa’ya yayılan
Sanayi Devrimi döneminde belediye binaları, hastaneler, tren istasyonları, okullar, müzeler
ve kütüphaneler gibi kamu binaları inşa edilmiş ve kaplama malzemelerine talep
artmıştır. Mermer ve taş zeminlere ucuz ve zarif bir alternatif olan seramikler, bu yapıların
ve yeni oluşan orta sınıfın konutları için üretilmiştir. Karoların dekorasyonu için
köklü kültüre sahip olan ülkelerin sanatlarından ilham alınmıştır. Tüm dünya müzelerinin
en seçkin koleksiyonları arasında yer alan Osmanlı çini ve seramikleri de bunların
arasındadır. Bu makalede, seramik endüstrisinin gelişmesinde önemli bir role sahip olan
Minton, Hollins & Co. firması tarafından üretilen karolardaki İznik desenleri araştırılarak
değerlendirilmiştir.
Use of Centrality Metrics to Protect Wildlife Ecology and Habitat Connectivity Analysis
Authors: SÜTÜN Huriye Simten 
Published: December 2021

Aim of study: Aim of this study was to conduct a habitat connectivity analysis using centrality metrics to protect the regional wildlife-habitat connections of the Siirt landscape, and to ensure the continuity of ecological flows in the landscape.
Area of study: Increasing urbanisation trend in recent years and human impact on natural resources cause the diversity in Siirt landscape to be negatively affected. Centrality metrics were sampled in Siirt landscape in terms of re-establishing and maintaining the connectivity in the landscape.
Material and methods: Environmental Plan was used to define the core areas. Land cover/land uses were digitised using Geographical Information Systems. Firstly, landscape connectivity corridors defined with least-cost-path and secondly, current flow centrality was used with circuit theory.
Main results: The core area with the strongest flow centrality was forest, with a value of 14.6, and the core area with the weakest flow centrality was marsh at 8.23. The core areas that establish the easiest and strongest connection with each other are wetland-pasture, pasture-geologically reserved area, and pasture-ecological area.
Highlights: The greater the distance between core areas, the weaker the degree of connectivity between species and habitats. Increasing the distance between core areas negatively affects the ecological flow.
Genomic and Functional Characterization of Heat Shock Protein Families in Jujube Genome (Ziziphus jujuba) by in silico Methods
Authors: CEYLAN Yusuf , CEYLAN Kevser Betül , ÇELİK ALTUNOĞLU Yasemin , BALOĞLU Mehmet Cengiz 
Published: December 2021

Aim of study: It was aimed to identify and characterize Hsp genes in jujube genome using genomics methods.
Material and method: Protein sequences of jujube Hsp genes were obtained from NCBI databases. GSDS program was used to detect of exon-intron sites. To define the conserved motifs and estimated 3D-structures, Hsp proteins were used in the MEME-SUITE and PHYRE2 program, respectively. miRNAs targeting ZjuHsp transcripts were identified using the psRNATarget Server database. The gene annotations of Hsp proteins were presented by Blast2GO program. Sequence alignment was performed with ClustalW software, and then the phylogenetic tree was drawn using MEGAX program.
Main results: A total of 474 genes were defined in the jujube genome. The amino acid length of the Hsp proteins changes from 75 aa to 2577 aa. The estimated 3-D structure of the ZjuHsp proteins revealed the dominance of the α-helix structure. Phylogenetic tree was constructed to detect evolutionary relationships revealed the eight major groups of the ZjuHsp100 and ZjuHsp60. ZjuHsp proteins could be mainly found in cell parts, membranes, and organelles. It was determined that the ZjuHsp100 genes was targeted by 313 miRNAs.
Highlights: This study helps the researchers who would like to comparative and functional genomic studies.
Correction of Astigmatism by a Single-Focus Toric Intraocular Lens during Cataract Surgery: Refractive State and Visual Acuity
Authors: Alnoelaty Almasri M.A. , Stebnev V. C. 
Published: December 2021

Purpose: the main purpose of study is to obtain a better visual outcome after implantation of a monofocal toric IOLs by accurate measurement, calculations and visual assessment.Methods. Fifty eyes with astigmatism of more than 2.5 D were included in a hospital-based prospective study. A biometric evaluation is done by Lenstar. Barette's toric calculation method is used to measure toric IOLs power. In a vertical position, preoperative axis marking was done by both bubble marker and direct slit beam. On table, in a horizontal position, axis marking was reassessed. After phacoemulsification, a monofocal Supra Phob toric IOL was implanted and rotated to match corneal axis marking. Best-corrected visual acuity was measured postoperatively at 1 and 3 months.Results. Reduction of mean of refractive astigmatism was reported postoperatively from 4.0 ± 0.79 preoperatively to 0.7 ± 0.28 at 1 month and 0.6 ± 0.27 at 3 months postoperatively. In whole, 96 % has residual astigmatism less than 1 D at 3 months postoperatively, while 8 % eyes had residual astigmatism more than 1 D. In whole, 76 % patients had IOLs rotation of less than or equal to 5°, 20 % patients had it between 6° and 10° and 4 % eyes had more than 10° at day 7 postoperatively, in which repositioning of IOLs was required.Conclusion. To reduce postoperative residual astigmatism after toric IOLs and to get better results, accurate measurement of parameters and proper calculation are essential.