bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrahigh Spatial Resolution, Fast Decay, and Stable X‐Ray Scintillation Screen through Assembling CsPbBr3 Nanocrystals Arrays in Anodized Aluminum Oxide
Authors: Li Huihui , Yang Heng , Yuan Rui , Sun Zhixiang , Yang Yunling , Zhao Jingtai , Li Qianli , Zhang Zhijun 
Published: October 2021

AbstractA scintillation screen with ultrahigh spatial resolution, fast decay time, and high stability is the key to commercial application. Herein, a pixelated‐structure scintillation screen of CsPbBr3 nanocrystal arrays based on anodized aluminum oxide (AAO) is reported, and its scintillation properties for X‐ray imaging are explored. It is of note that ultrahigh spatial resolution (2 µm), fast photoluminescence decay time (9 ns), and high stability (>42 d) are successfully achieved by the pixelated CsPbBr3‐AAO arrays scintillation screen. Considering the decent scintillation properties and high stability, one has reason to assume that the pixelated CsPbBr3‐AAO arrays scintillation screen may find an application as a new X‐ray scintillation screen.
Room‐Temperature Multiferroicity and Magnetization Dynamics in Fe/BTO/LSMO Tunnel Junction
Authors: Pawlak Jakub , Skowroński Witold , Żywczak Antoni , Przybylski Marek 
Published: October 2021

AbstractThis article describes the static, dynamic, and temperature dependent magneto‐transport properties of the Fe/BTO/LSMO mutliferroic tunnel junction (MFTJ). The multilayer structure is grown on a high quality crystalline STO substrate by means of pulsed laser deposition, which enables epitaxial layer‐by‐layer growth. The MFTJ is patterned into micrometer‐size devices by means of the ion‐etching‐free lithography process ensuring that the properties of the oxide layers are preserved after the device fabrication. The measured static properties indicate that the MFTJ has multiferroic properties at room temperature with the tunneling electroresistance (TER) and tunneling magnetoresistance (TMR) reaching 270% and 0.4%, respectively. The temperature measurements indicate the exponentially decreasing dependence of TMR with increasing temperature, whereas TER is temperature independent. The electric ferromagnetic resonance measurements based on the spin‐diode effect shows the existence of two resonance peaks, from both ferromagentic electrodes, one identified as LSMO‐derived and characterized by low magnetization damping of α = 0.002 and the other from the Fe.
Spin‐Orbit Torque and Interfacial Dzyaloshinskii–Moriya Interaction in Heavy Metal/Ferrimagnetic Insulator Deposited by Magnetron Sputtering
Authors: Ye Zhixiang , Chen Zhiren , Chen Zehan , Jia Wei , Gao Tenghua , Liu Lin , Zheng Hongnan , Zeng Qi , Wang Qiuning , Wang Ning , Xiang Boyuan , Lin Tao , Qiu Mingxia , Li Shunpu , Shi Ji , Hou Zhipeng , Ando Kazuya , An Hongyu 
Published: October 2021

AbstractFerrimagnetic insulators (FMIs) have abundant advantages for the application in spintronic devices, which have attracted intensive studies. However, in most previous studies on heavy metal (HM)/FMI bilayers, the FMI layers are deposited by pulsed laser deposition (PLD), and the HM layers are deposited by magnetron sputtering. This will cause the interfacial contamination due to the inevitable vacuum breaking, and then significantly affect the spin‐orbit torque (SOT) generation and the Dzyaloshinskii–Moriya interaction (DMI) in the HM/FMI bilayers. In this work, the SOT and DMI in the HM/FMI bilayers deposited by magnetron sputtering without vacuum breaking are studied. The successful fabrication of the Tm3Fe5O12 (TmIG) layer, a typical FMI, with good crystallinity and perpendicular magnetic anisotropy (PMA) by magnetron sputtering is first demonstrated. Then by systematically varying the TmIG thickness, the SOT and DMI in the Pt/TmIG bilayers are studied. It is shown that the effective spin Hall angle in the Pt/TmIG bilayers is much larger than most previously reported values. It is further demonstrated that the DMI constant scales linearly with the inverse of the TmIG thickness, indicating the interfacial origin of the DMI. The study provides a piece of information for the basic understandings of the SOT and DMI in the HM/FMI bilayers.
Koolen‐de Vries syndrome in a 63‐year‐old woman: Report of the oldest patient and a review of the adult phenotype
Authors: Farnè Marianna , Bernardini Laura , Capalbo Anna , Cavarretta Giusy , Torres Barbara , Sanchini Mariabeatrice , Fini Sergio , Ferlini Alessandra , Bigoni Stefania 
Published: October 2021

AbstractKoolen‐de Vries syndrome (KdVS) is a rare genetic disorder caused by a de novo microdeletion in chromosomal region 17q21.31 encompassing KANSL1 or by a de novo intragenic pathogenic variant of KANSL1. KdVS is typically characterized by intellectual disability (ID), variable from mild to severe, developmental psychomotor delay, especially of expressive language development, friendly disposition, and multiple systemic abnormalities. So far, most of the individuals affected by KdVS are diagnosed in infancy or in adolescence; to the best of our knowledge, only 34 (including ours) adults have been reported in literature. Here we present the adult phenotype of a 63‐year‐old Italian woman affected by KdVS, caused by a 17q21.31 microdeletion. She is, to our knowledge, the oldest affected individual reported so far. We collected her clinical history and photographs, as well as those of other 26 adult patients described so far and compared her to them. We propose that the cardinal features of KdVS in adulthood are ID (ranging from mild to severe, usually moderate), friendly behavior, musculoskeletal abnormalities (especially scoliosis), and facial dysmorphism (a long face and a pronounced pear‐shape nose with bulbous overhanging nasal tip). Therefore, we suggest considering KdVS in differential diagnosis in adult patients characterized by these features.
Profile of Autism Spectrum Disorder in Tuberous Sclerosis Complex: Results from a Longitudinal, Prospective, Multisite Study
Authors: Capal Jamie K. , Williams Marian E. , Pearson Deborah A. , Kissinger Robin , Horn Paul S. , Murray Donna , Currans Kristn , Kent Bridget , Bebin Martina , Northrup Hope , Wu Joyce Y. , Sahin Mustafa , Krueger Darcy A. ,   TACERN Study Group
Published: October 2021

ObjectiveTuberous sclerosis complex (TSC) is highly associated with autism spectrum disorder (ASD). Objectives of the study were to characterize autistic features in young children with TSC.MethodsParticipants included 138 children followed from ages 3 to 36 months with TSC from the Tuberous Sclerosis Complex Autism Center of Excellence Research Network (TACERN), a multicenter, prospective observational study aimed at understanding the underlying mechanisms of ASD in TSC. Developmental and autism‐specific assessments were administered, and a clinical diagnosis of ASD was determined for all participants at 36 months. Further analyses were performed on 117 participants with valid autism assessments based on nonverbal mental age greater than 15 months.ResultsPrevalence of clinical diagnosis of ASD at 36 months was 25%. Nearly all autistic behaviors on the Autism Diagnostic Observation Schedule‐2 (ADOS‐2) and Autism Diagnostic Interview‐Revised (ADI‐R) were more prevalent in children diagnosed with ASD; however, autism‐specific behaviors were also observed in children without ASD. Overall quality of social overtures, facial expressions, and abnormal repetitive interests and behaviors were characteristics most likely to distinguish children with ASD from those without an ASD diagnosis. Participants meeting ADOS‐2 criteria but not a clinical ASD diagnosis exhibited intermediate developmental and ADOS‐2 scores compared to individuals with and without ASD.InterpretationASD is highly prevalent in TSC, and many additional individuals with TSC exhibit a broad range of subthreshold autistic behaviors. Our findings reveal a broader autism phenotype that can be identified in young children with TSC, which provides opportunity for early targeted treatments. ANN NEUROL 2021;90:874–886
Assessing how students value learning communication skills in an undergraduate anatomy and physiology course
Authors: Cline Christina , Santuzzi Alecia M. , Samonds Karen E. , LaDue Nicole , Bergan‐Roller Heather E. 
Published: October 2021

AbstractStudents, particularly those in science, technology, engineering and mathematics (STEM) and healthcare‐related programs, should develop proficient interpersonal skills, including communication. To help students develop effective communication skills, instructors need to consider the value students give to learning these skills. The Student Attitudes Toward Communication Skills Survey (SATCSS) was developed to measure how undergraduate students value learning communication skills based on Expectancy‐Value Theory across three modes of communication (verbal, written, non‐verbal). The survey was given to students interested in healthcare professions and enrolled in an undergraduate anatomy and physiology (A&P) course (n= 233) at a Midwest research active university. The survey showed evidence of validity, measuring two components: (1) “Value to Profession” (attainment and utility value) and (2) “Value to Self” (intrinsic value and cost). There was a significant difference in sub‐scores among the four task values such that students thought that learning communication skills was important and relevant (high attainment and utility value) but not interesting (low intrinsic value) and costly. Students with high total scores valued communication skills across all four task values. As total value scores decreased, it was first due to students finding learning communication skills to be time prohibitive and then a lack of interest in learning communication skills. Based on these results, it is recommended that instructors incorporate communication skills training into content that is already part of their A&P course to reduce time concerns. Additional recommendations include using reflective activities and humor to increase student interest.
CO2‐Reduktion in der gebauten Umwelt – Von der Formulierung strategischer Leitlinien bis zur Planung und Umsetzung
Authors: Müller Sabine , Scheibstock Peter 
Published: October 2021

AbstractDer Bericht beleuchtet Ansätze, Strategien und Instrumente zur CO2‐Reduktion in der gebauten Umwelt. Dabei wird hier die frühzeitige Einbindung der CO2‐Thematik in der Leistungsphase 0 bzw. Projektkonzeption betrachtet, in der die Zielsetzung eines Projekts festgelegt wird. In dieser Phase können ausschlaggebende Leitlinien zur Reduktion grauer sowie Betriebsemissionen formuliert werden, die wesentlich die Ausschreibung und Umsetzung eines Projekts beeinflussen. Ebenso wird erläutert, wie im weiteren Fortschritt das Erreichen von CO2‐Zielen unterstützt und auch gewährleistet werden kann. Dabei liegt der Fokus auf der Berechnung des globalen Erwärmungspotenzials (GWP) von Tragwerkskonstruktionen, da CO2 hier in besonderem Maße durch seine Baumasse relevant ist. Es wird diskutiert, in welcher Leistungsphase solche Berechnungen und Betrachtungen sinnvoll sind, um einen Beitrag zur CO2‐Reduktion zu leisten. Anhand eines aktuell in der Erstellung befindlichen Bürogebäudes werden Tragwerkskonzepte in Bezug auf ihre Ökobilanz gegenübergestellt. Die Bauindustrie ist verantwortlich für ca. 40 % der globalen CO2‐Emissionen. Als Ingenieur:innen haben wir die Verantwortung und Möglichkeiten, diesen Wert wesentlich zu beeinflussen. Buro Happold als interdisziplinäres Beratungs‐ und Planungsbüro kann dabei auf fachübergreifende Expertise zurückgreifen, die es erlaubt, Projekte von der ersten Idee bis zur Umsetzung zu begleiten. Somit kann ein möglichst großer positiver Einfluss hinsichtlich Nachhaltigkeit und CO2‐Fußabdruck erzielt werden. Die Autorin und der Autor mit ihrem Hintergrund aus Tragwerksplanung und Nachhaltigkeitsberatung zeigen das Potenzial dieses integrierten Ansatzes auf.
Network‐based rTMS to modulate working memory: The difficult choice of effective parameters for online interventions
Authors: Beynel Lysianne , Dannhauer Moritz , Palmer Hannah , Hilbig Susan A. , Crowell Courtney A. , Wang Joyce E‐H. , Michael Andrew M. , Wood Eleanor A. , Luber Bruce , Lisanby Sarah H. , Peterchev Angel V. , Cabeza Roberto , Davis Simon W. , Appelbaum Lawrence G. 
Published: October 2021

AbstractBackgroundOnline repetitive transcranialmagnetic stimulation (rTMS) has been shown to modulate working memory (WM) performance in a site‐specific manner, with behavioral improvements due to stimulation of the dorsolateral prefrontal cortex (DLPFC), and impairment from stimulation to the lateral parietal cortex (LPC). Neurobehavioral studies have demonstrated that subprocesses of WM allowing for the maintenance and manipulation of information in the mind involve unique cortical networks. Despite promising evidence of modulatory effects of rTMS on WM, no studies have yet demonstrated distinct modulatory control of these two subprocesses. The current study therefore sought to explore this possibility through site‐specific stimulation during an online task invoking both skills.MethodsTwenty‐nine subjects completed a 4‐day protocol, in which active or sham 5Hz rTMS was applied over the DLPFC and LPC in separate blocks of trials while participants performed tasks that required either maintenance alone, or both maintenance and manipulation (alphabetization) of information. Stimulation targets were defined individually based on fMRI activation and structural network properties. Stimulation amplitude was adjusted using electric field modeling to equate induced current in the target region across participants.ResultsDespite the use of advanced techniques, no significant differences or interactions between active and sham stimulation were found. Exploratory analyses testing stimulation amplitude, fMRI activation, and modal controllability showed nonsignificant but interesting trends with rTMS effects.ConclusionWhile this study did not reveal any significant behavioral changes in WM, the results may point to parameters that contribute to positive effects, such as stimulation amplitude and functional activation.
Oxytocin receptor polymorphism influences characterization of harm avoidance by moderating susceptibility to affectionless control parenting
Authors: Noto Keisuke , Suzuki Akihito , Shirata Toshinori , Matsumoto Yoshihiko , Muraosa Haruka , Goto Kaoru , Otani Koichi 
Published: October 2021

AbstractIntroductionOxytocin receptor (OXTR) gene polymorphism reportedly moderates effects of negative environments during childhood on mental function and behavior such as depressive symptoms and externalizing problems. This study examined OXTR gene polymorphism effects on personality traits in healthy participants, considering interaction effects of polymorphism with affectionless control (AC) parenting which is one of the dysfunctional and pathogenic parenting styles.MethodsFor 496 Japanese volunteers, personality was evaluated using the Temperament and Character Inventory. The Parental Bonding Instrument, which has subscales of care and protection, was used to assess perceived parental rearing. AC parenting was defined as low care and high protection. A/G polymorphism of the OXTR gene (rs53576) was detected using TaqMan SNP Genotyping Assay.ResultsTwo‐way analysis of covariance revealed significant interaction effects between the genotype and the number of AC parents on scores of harm avoidance, with no significant main effect of genotype on any personality. Post‐hoc analysis revealed that the harm avoidance scores were increased in a stepwise manner with respect to the increase of the number of AC parents in the A allele carriers. No similar association was observed in the A allele noncarriers.ConclusionThe results of this study suggest that OXTR polymorphism influences characterization of harm avoidance by moderating susceptibility to AC parenting.
Acute macular neuroretinopathy as a manifestation of coronavirus disease 2019: A case report
Authors: Masjedi Marjan , Pourazizi Mohsen , Hosseini Nastaran‐Sadat 
Published: October 2021

AbstractThe current findings is important in raising clinicians' awareness of the possibility of coincident acute macular neuroretinopathy (AMN) and COVID‐19 as a potential cause of retinal vascular damage and ischemia.
Optimization of a New Integrated Separation Process for Azeotropes Based on Genetic Programming
Authors: Wang Xiao-Hong , Ding Xin , Du Peng , Tian Zeng-Hu , Chen Jing-Xuan 
Published: October 2021

AbstractA solution strategy of a distillation‐membrane separation process based on genetic programming algorithm (GP) is proposed. It can automatically match diverse membrane materials according to different azeotropic systems and generate various integrated processes. For the membrane, which is still in the experimental research stage, a theoretical prediction method of membrane cost is recommended. Taking the benzene‐cyclohexane system as an example, a GO‐AgNPs/PI membrane and polyurethane membrane were matched, respectively, and the optimal integrated processes can be obtained. The GP strategy provides a strong guidance for the comprehensive design and optimization of distillation‐membrane separation by using various new membranes.
In‐Situ Electronegativity and the Bridging of Chemical Bonding Concepts
Authors: Racioppi Stefano , Rahm Martin 
Published: October 2021

AbstractOne challenge in chemistry is the plethora of often disparate models for rationalizing the electronic structure of molecules. Chemical concepts abound, but their connections are often frail. This work describes a quantum‐mechanical framework that enables a combination of ideas from three approaches common for the analysis of chemical bonds: energy decomposition analysis (EDA), quantum chemical topology, and molecular orbital (MO) theory. The glue to our theory is the electron energy density, interpretable as one part electrons and one part electronegativity. We present a three‐dimensional analysis of the electron energy density and use it to redefine what constitutes an atom in a molecule. Definitions of atomic partial charge and electronegativity follow in a way that connects these concepts to the total energy of a molecule. The formation of polar bonds is predicted to cause inversion of electronegativity, and a new perspective of bonding in diborane and guanine−cytosine base‐pairing is presented. The electronegativity of atoms inside molecules is shown to be predictive of pKa.
Photoelectrochemical Biosensor for 5‐Formylcytosine Based on WS2/Bi/Bi2O2CO3 Nanocomposite and Rolling Circle Amplification
Authors: Wang Qian , Yin Huanshun , Zhou Yunlei , Cao Lulu , Yu Zhengkun , Xu Yamin , Ai Shiyun 
Published: October 2021

Comprehensive SummaryAs a key epigenetic modification, 5‐formylcytosine (5fC) controls many important cell functions, such as gene expression and cell differentiation. However, 5fC exists in mammalian tissues and cells with low content, and its structure is highly similar to 5‐methylcytosine (5mC), 5‐hydroxymethylcytosine (5hmC) and 5‐carboxycytosine (5caC), which requires the detection method for detecting 5fC with high sensitivity and specificity. In this experiment, WS2/Bi/Bi2O2CO3 was used as the photoactive material, 5fC antibody was used as the target molecule recognition reagent, and rolling amplification (RCA) was employed as the signal amplification strategy to construct a novel photoelectrochemical biosensor for detecting 5‐formylcytosine deoxynucleotide (5fdCTP). Firstly, WS2/Bi/Bi2O2CO3 nanocomposite was prepared and characterized, and then modified on the ITO electrode. Then, polyacrylic acid (PAA) was immobilized by electrostatic adsorption, which was employed as the antibody capture reagent based on the covalent reaction of –COOH on PAA with –NH2 on Ab. Subsequently, 5fdCTP was recognized through immunoreaction, triggering the subsequent rolling circle amplification reaction with the aid of the crosslinker of Zr4+. Finally, positive methylene blue (MB) was adsorbed by negative ssDNA, resulting in an increased photoelectric conversion efficiency of WS2/Bi/Bi2O2CO3 and improved detection sensitivity. The linear range of the PEC biosensor for detecting 5fdCTP was 0.05—100 nmol/L, and the minimum detection concentration was 12.4 pmol/L (S/N = 3). The applicability of this method has been evaluated by studying the influence of Cd2+ and antibiotic concentration on the 5fC content in the genomic DNA of maize seedlings.
Covid19‐Mexican‐Patients' Dataset (Covid19MPD) Classification and Prediction Using Feature Importance
Authors: Almustafa Khaled Mohamad 
Published: October 2021

SummaryCoronavirus disease, Covid19, pandemic has a great effect on human heath worldwide since it was first detected in late 2019. A clear understanding of the structure of the available Covid19 datasets might give the healthcare provider a better understanding of identifying some of the cases at an early stage. In this article, we will be looking into a Covid19 Mexican Patients' Dataset (Covid109MPD), and we will apply number of machine learning algorithms on the dataset to select the best possible classification algorithm for the death and survived cases in Mexico, then we will study the performance of the enhancement of the specified classifiers in term of their features selection in order to be able to predict sever, and or death, cases from the available dataset. Results show that J48 classifier gives the best classification accuracy with 94.41% and RMSE = 0.2028 and ROC = 0.919, compared to other classifiers, and when using feature selection method, J48 classifier can predict a surviving Covid19MPD case within 94.88% accuracy, and by using only 10 out of the total 19 features.
Real‐World Data of Palbociclib in Combination With Endocrine Therapy for the Treatment of Metastatic Breast Cancer in Men
Authors: Kraus Albert L. , Yu‐Kite Michelle , Mardekian Jack , Cotter Matthew J. , Kim Sindy , Decembrino Jaclyn , Snow Tamara , Carson Kenneth R. , Motyl Rockland Jillian , Gossai Anala , Wilner Keith , Wang Diane D. , Huang Bartlett Cynthia , Oharu Norihiko , Schnell Patrick , VanArsdale Todd , Lu Dongrui R. , Tursi Jennifer M. 
Published: October 2021

This report examined the benefits and risks of palbociclib plus endocrine therapy (ET) in men with hormone receptor‒positive (HR+)/human epidermal growth factor receptor 2−negative (HER2−) metastatic breast cancer (MBC). Palbociclib was evaluated using three independent data sources: real‐world data from pharmacy and medical claims, a de‐identified real‐world data source derived from electronic health records (EHRs), and a global safety database. From medical and pharmacy records, 1,139 men with MBC were identified; in the first‐line setting, median duration of treatment was longer with palbociclib plus ET (n = 37, 8.5 months, 95% confidence interval (CI), 4.4‒13.0) than ET alone (n = 214, 4.3 months, 95% CI, 3.0‒5.7) and specifically, was longer with palbociclib plus letrozole (n = 26, 9.4 months, 95% CI, 4.4‒14.0) than letrozole alone (n = 63, 3.0 months, 95% CI, 1.8‒4.8). In the EHR‐derived database, 59 men received treatment for MBC; real‐world response across all lines of therapy in the metastatic setting was reported in 4 of 12 patients (33.3%) in the palbociclib plus ET group vs. 1 of 8 (12.5%) patients in the ET group. Review of the global safety database did not identify any new safety signals in palbociclib‐treated men. Real‐world data indicated that men with MBC benefit from palbociclib plus ET, with a safety profile consistent with previous observations in women with MBC. Collective data on palbociclib in women and men in this report, including clinical trial data, real‐world data, and a well‐established risk/benefit profile, led to US approval of an expansion of the palbociclib indication to include men with MBC.