bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polymeric Nanoreactors as Emerging Nanoplatforms for Cancer Precise Nanomedicine
Authors: Li Xin , Zhao Xiaopeng , Lv Runkai , Hao Linhui , Huo Fengwei , Yao Xikuang 
Published: April 2021

AbstractHow to precisely detect and effectively cure cancer which is defined as precise nanomedicine has drawn great attention worldwide. Polymeric nanoreactors which can in situ catalyze inert species into activated ones, can greatly increase imaging quality and enhance therapeutic effects along with decreased background interference and reduced serious side effects. After a brief introduction, the design and preparation of polymeric nanoreactors are discussed from the following aspects, that is, solvent‐switch, pH‐tuning, film rehydration, hard template, electrostatic interaction, and polymerization‐induced self‐assembly (PISA). Subsequently, the biomedical applications of these nanoreactors in the fields of cancer imaging, cancer therapy, and cancer theranostics are highlighted. The last but not least, conclusions and future perspectives about polymeric nanoreactors are given. It is believed that polymeric nanoreactors can bring a great opportunity for future fabrication and clinical translation of precise nanomedicine.
First‐order undefinability of the notion of transfinitely uplifting cardinals
Authors: Fujimoto Kentaro 
Published: April 2021

AbstractAudrito and Viale introduced the new large cardinal notion of an (α)‐uplifting cardinal (for an ordinal α). We shall show that this notion cannot be defined (or expressed) in the standard first‐order language of set theory for every tranfinite α.
Sulfophenylated Poly (Ether Ether Ketone Ketone) Nanofiber Composite Separator with Excellent Electrochemical Performance and Dimensional Thermal Stability for Lithium‐Ion Battery via Electrospinning
Authors: Hu Wei , Liang Xiaoxiao , Yang Xue , You Yingxue , Zhao Qi , Liu Baijun , Sun Zhaoyan , Men Yongfeng , Zhu Guangshan , Xie Haiming 
Published: April 2021

AbstractIn this investigation, the sulfophenylated poly (ether ether ketone ketone) (SPEEKK) separators for lithium‐ion batteries (LIBs) are prepared via electrospinning. The electrospun sulfophenylated poly (ether ether ketone ketone) membranes (es‐SP) are then modified with lithium bis(trifuoro‐methanesulfonyl)imide (LiTFSI) by immersing in the LiTFSI/ethanol solution to obtain the modified es‐SP composite separators (es‐SP‐Li). SPEEKK displays excellent dimensional thermal stability, and thus the thermal shrinkage of es‐SP‐Li‐20 (20% of LiTFSI in ethanol) composite separators is only 2% after 0.5 h at 200 °C. The strong polarity of sulfonic acid groups on SPEEKK and LiTFSI enhances the electrolyte wettability and uptake, and thus afford more Li source, so as to promote the conductivity of lithium ions in the composite separators, which in turn exhibit positive impacts on the rate and cycling stability performance of LIBs. The Li//LiFePO4 cells assembled with es‐SP‐Li‐20 separator demonstrate excellent electrochemical stability over 170 cycles at 0.2 C with a reversible discharge capacity of 153 mAh g−1, and a promising rate capacity at 2 C. In short, the as‐prepared es‐SP‐Li composite separators with excellent comprehensive property emerge as a promising application in LIBs.
How Do I Rehabilitate Patients with Cervical Dystonia Remotely?
Authors: Castagna Anna , Saibene Enrico , Ramella Marina 
Published: April 2021

ABSTRACTIn literature there is a growing evidence that in cervical dystonia (CD) rehabilitation, both in person and remotely, is an efficacious add on treatment to botulinum neurotoxins (BoNT) injections, but there is no consensus about protocols. We present here two rehabilitation programs implemented by our neuro‐rehabilitative multidisciplinary team. The enclosed video clips show exercises to be performed at home as self‐rehabilitation program, and exercises presented by a physiotherapist for a telerehabilitation program. These two protocols may be helpful for integrating rehabilitation with BoNT treatment in CD.
Whole‐exome sequencing analysis in 10 families of sporadic microtia with thoracic deformities
Authors: Yang Meirong , Lu Xiaosheng , Zhang Ye , Wang Changchen , Cai Zhen , Li Zhengyong , Pan Bo , Jiang Haiyue 
Published: April 2021

AbstractBackgroundMicrotia is a congenital malformation of the external ear and may occur as an isolated deformity or as part of a syndrome. Our previous study found a high correlation between microtia and thoracic deformities, thus, we propose that external ear and thorax development may be regulated by certain genes in common.MethodsWe performed exome sequencing on 10 families of sporadic microtia with thoracic abnormalities. We identified mutated genes under different models of inheritance, and checked them through Mouse Genome Informatics and association analysis.ResultsWe identified 45 rare mutations, including 9 de novo mutations, 20 heterozygous mutations, 3 homozygous mutations, and 13 hemizygous mutations, of which 2 are likely to be causative. They are de novo missense variant in PHF5A and compound heterozygous mutations in CYP26B1, of which CYP26B1 mutation is highly likely pathogenic.ConclusionThe results indicate that certain genes may affect both external ear and thorax development, and demonstrate the benefits of whole‐exome sequencing in identifying candidate genes of microtia. This study provides a new way for genetic exploration in microtia.
Founder mutation in the PMM2 promotor causes hyperinsulinemic hypoglycaemia/polycystic kidney disease (HIPKD)
Authors: Islam Sumaya , Tekman Mehmet , Flanagan Sarah E. , Guay‐Woodford Lisa , Hussain Khalid , Ellard Sian , Kleta Robert , Bockenhauer Detlef , Stanescu Horia , Iancu Daniela 
Published: April 2021

AbstractBackgroundPolycystic kidney disease with hyperinsulinaemic hypoglycaemia (HIPKD) is a recently described disease caused by a single nucleotide variant, c.‐167G>T, in the promoter region of PMM2 (encoding phosphomannomutase 2), either in homozygosity or compound heterozygosity with a pathogenic coding variant in trans. All patients identified so far are of European descent, suggesting a possible founder effect.MethodsWe generated high density genotyping data from 11 patients from seven unrelated families, and used this information to identify a common haplotype that included the promoter variant. We estimated the age of the promoter mutation with DMLE+ software, using demographic parameters corresponding to the European population.ResultsAll patients shared a 0.312 Mb haplotype which was absent in 503 European controls available in the 1000 Genomes Project. The age of this mutation was estimated as 105–110 generations, indicating its occurrence around 600 BC, a time of intense migration, which might explain the presence of the same mutations in Europeans around the globe.ConclusionThe shared unique haplotype among seemingly unrelated patients is consistent with a founder effect in Europeans.
Novel HEXA variants in Korean children with Tay–Sachs disease with regression of neurodevelopment from infancy
Authors: Park Ji Hong , Ko Jung Min , Kim Min Sun , Kim Man Jin , Seong Moon‐Woo , Yoo Taekyeong , Lim Byung Chan , Chae Jong‐Hee 
Published: April 2021

AbstractBackgroundTay–Sachs disease (TSD) is a lysosomal storage disease caused by mutations in the HEXA gene that encodes the HexosaminidaseA (HEXA) enzyme. As HEXA normally functions to degrade the protein GM2‐ganglioside in lysosomes, decreased levels of HEXAcauses an accumulation of the protein and leads to neurological toxicity. Typical clinical manifestations of TSD include neurodevelopmental regression, muscle weakness, hypotonia, hyperreflexia, ataxia, seizures, and other neurological symptoms. It is quite rare in Asian populations, wherein only two cases have been reported in Korea to date.MethodsClinical records, radiological assessments, and laboratory findings, such as plasma hexosaminidase assay and HEXA analysis, were extracted from the medical records of three (1 male and 2 female) independent Korean children with infantile form of Tay–Sachs disease.ResultsAll three children presented with neurodevelopmental regression and strabismus at around 8 months of age. Presence of cherry‐red spots in the macula led to conduction of biochemical and genetic studies for TSD confirmation. The plasma hexosaminidase assay revealed decreased HEXA activity and low to normal total hexosaminidase activity. Similarly, genetic analysis revealed 4 variants from 6 alleles, including 2 previously reported and 2 novel variants, in the HEXA gene.ConclusionWe presented three Korean children, who were recently diagnosed with infantile‐type TSDvia enzyme assay and genetic analysis. Furthermore, results showed that fundus examination can be helpful for early diagnosis of children with neurodevelopmental regression.
Lymphaticovenular anastomosis for lymph vessel injury in the pelvis and groin
Authors: Kadota Hideki , Shimamoto Ryo , Fukushima Seita , Inatomi Yusuke , Ikemura Ko , Miyashita Kayo , Kamizono Kenichi , Hanada Masuo , Yoshida Sei 
Published: April 2021

AbstractBackgroundLymphatic diseases due to lymph vessel injuries in the pelvis and groin require immediate clinical attention when conventional treatments fail. We aimed to clarify the effectiveness of and indications for lymphaticovenular anastomosis (LVA) to treat these lymphatic diseases.MethodsWe retrospectively evaluated six patients who underwent LVA for lymphatic diseases due to lymph vessel injuries in the pelvis and groin. Specific pathologies included groin lymphorrhea (N = 3), chylous ascites (N = 2), and retroperitoneal lymphocele (N = 1). The maximum lymphatic fluid leakage volume was 150–2600 mL daily. Conventional treatments (compression, drainage, fasting, somatostatin administration, negative pressure wound therapy, or lymph vessel ligation) had failed to control leakage in all cases. We performed lower extremity LVAs after confirming the site of lymph vessel injury using lymphoscintigraphy. We preferentially placed LVAs in thigh sites that showed a linear pattern by indocyanine green lymphography. Postoperative lymphatic fluid leakage volume reduction was evaluated, and leakage cessation was recorded when the drainage volume approached 0 mL.ResultsLVA was performed at an average of 4.3 sites (range, 3–6 sites) in the thigh and 2.7 sites (range, 0–6 sites) in the lower leg. Lymphatic fluid leakage ceased in all cases after a mean of 6 days (range, 1–11 days) postoperatively. No recurrence of symptoms was observed during an average follow‐up of 2.9 (range, 0.5–5.5) years.ConclusionsLVA demonstrates excellent and rapid effects. We recommend lower extremity LVA for the treatment of lymphatic diseases due to lymph vessel injuries in the pelvis and groin.
A low‐profile microstrip patch array with broadband and wide‐angle scanning characteristics
Authors: Sun Dan , Yuan Congcong , Su Pei 
Published: April 2021

AbstractA low‐profile broadband patch array antenna with a wide scanning range is presented at X‐band. The antenna element consists of the stacked patches, the sheet resistances and the metallic posts with a total thickness of 3.27 mm. The stacked patches are excited by a stripline‐fed aperture with four edge patches surrounding the bottom patch. The sheet resistances and the metallic posts provide a solution to ameliorate the matching responses, besides promoting the scanning angle. The simulated active VSWRs are below 2 and 2.6 as scan ranges ± 60° and ± 70°, respectively, over a bandwidth of 40%. As an example, a prototype array with 8 × 8 elements was fabricated to verify the method. Its measured active VSWRs are lower than 2.4 and 2.9 with the maximum losses of 1.6 dB in the scan angles above.
Specific absorption rate and temperature in neonate models resulting from exposure to a 7T head coil
Authors: Malik Shaihan J. , Hand Jeffrey W. , Satnarine Ryan , Price Anthony N. , Hajnal Joseph V. 
Published: April 2021

PurposeTo investigate safe limits for neonatal imaging using a 7T head coil, including both specific absorption rate (SAR) and temperature predictions.MethodsHead‐centered neonate models were simulated using finite‐difference time domain–based electromagnetic and thermal solvers. The effects of higher water content of neonatal tissues compared with adults, position shifts, and thermal insulation were also considered. An adult model was simulated for comparison.ResultsMaximum and average SAR are both elevated in the neonate when compared with an adult model. When normalized to , the SAR experienced by a neonate is greater than an adult by approximately a factor of 2; when normalized to net forward power (forward‐reflected), this increases to a factor of 2.5‐3.0; and when normalized to absorbed power, approximately a factor of 4. Use of age‐adjusted dielectric properties significantly increases the predicted SAR, compared with using adult tissue properties for the neonates. Thermal simulations predict that change in core temperature/maximum temperature remain compliant with International Electrotechnical Commission limits when a thermally insulated neonate is exposed at the SAR limit for up to an hour.ConclusionThis study of two neonate models cannot quantify the variability expected within a larger population. Likewise, the use of age‐adjusted dielectric properties have a significant effect, but while their use is well motivated by literature, there is uncertainty in the true dielectric properties of neonatal tissue. Nevertheless, the main finding is that unlike at lower field strengths, operational limits for 7T neonatal MRI using an adult head coil should be more conservative than limits for use on adults.
Dynamic regulation on innovation and adoption of green technology with information asymmetry
Authors: Rong Lisong , Chen Jian , Wen Zhong 
Published: April 2021

AbstractThis study investigates a regulator's dynamic policy to motivate firms' research on and adoption of green technology. In the proposed model, a firm makes unobservable efforts and can hide the technology's arrival from the regulator to avoid adoption costs. We find that the optimal policy follows a simple structure and induces part‐time efforts, rather than the maximal effort reported in previous studies. In particular, the regulator should offer no subsidy before the arrival of a technology report, provide a one‐time subsidy contingent upon that report, and always set a termination deadline. At the deadline, the firm is forced to select an external option that is associated with social costs. The optimal report‐based subsidy decreases with time. Under the optimal policy, the firm works until an effort deadline, makes no effort thereafter, and reports the technology as soon as it arrives. This study also characterizes the necessary and sufficient conditions under which the optimal policy reduces to one that leads, in terms of throughout time, to effort that is maximal or minimal. Our results indicate that policymakers should implement a policy that compensates firms more in the present and less in the future.
Effect of self‐administration of medication programme on cardiovascular inpatients' medication adherence and nurses' satisfaction: A randomized clinical trial
Authors: Hajialibeigloo Reza , Mazlum Seyed Reza , Mohajer Samira , Morisky Donald E. 
Published: April 2021

AbstractAimTo investigate the effect of self‐administration of medication programme on medication adherence in cardiovascular inpatients and nurse's satisfaction.DesignRandomized clinical trial with parallel‐group design guided by the CONSORT checklist.MethodsIn this study, sixty cardiovascular inpatients were selected through convenience sampling and then randomly assigned to control and intervention groups, in 2018, Iran.The intervention group took responsibility for consuming their prescribed medication according to the self‐administration of medication programme and the control group took medications routinely. Medication adherence was measured one and two weeks after the discharge via telephonic follow‐up by Morisky Medication Adherence Scale MMAS‐8‐item and nurses' satisfaction by researcher‐made questioner.ResultThere was a higher medication adherence level in the intervention group rather than the usual care group at the follow‐up. Most nurses in the study environment were very satisfied.ConclusionThe self‐administration of medication programme can effectively increase patients' medication adherence and nurses' satisfaction.
Ambient temperature and relative humidity–based drift correction in frequency domain electromagnetics using machine learning
Authors: Hanssens Daan , Vijver Ellen Van De , Waegeman Willem , Everett Mark E. , Moffat Ian , Sarris Apostolos , De Smedt Philippe 
Published: April 2021

ABSTRACTElectromagnetic instrument responses suffer from signal drift that results in a variable response at a given location over time. If left uncorrected, spatiotemporal aliasing can manifest and global trends or abrupt changes might be observed in the data, which are independent of subsurface electromagnetic variations. By performing static ground measurements, we characterized drift patterns of different electromagnetic instruments. Next, we performed static measurements at an elevated height, approximately 4 metre above ground level, to collect a data set that forms the basis of a new absolute calibration methodology. By additionally logging ambient temperature variations, battery voltage and relative humidity, a relation between signal drift and these parameters was modelled using a machine learning (ML) approach. The results show that it was possible to mitigate the effects of signal drift; however, it was not possible to completely eliminate them. The reason is three‐fold: (1) the ML algorithm is not yet sufficiently adapted for accurate prediction; (2) signal instability is not explained sufficiently by ambient temperature, relative humidity and battery voltage; and (3) the black‐box internal (factory) calibration impeded direct access to raw data, which prevents accurate evaluation of the proposed methodology. However, the results suggest that these challenges are not insurmountable and that ML can form a viable approach in tackling the drift problem instrument specific in the near future.
Multiomic Predictors of Short‐Term Weight Loss and Clinical Outcomes During a Behavioral‐Based Weight Loss Intervention
Authors: Siebert Janet C. , Stanislawski Maggie A. , Zaman Adnin , Ostendorf Danielle M. , Konigsberg Iain R. , Jambal Purevsuren , Ir Diana , Bing Kristen , Wayland Liza , Scorsone Jared J. , Lozupone Catherine A. , Görg Carsten , Frank Daniel N. , Bessesen Daniel , MacLean Paul S. , Melanson Edward L. , Catenacci Victoria A. , Borengasser Sarah J. 
Published: April 2021

ObjectiveIdentifying predictors of weight loss and clinical outcomes may increase understanding of individual variability in weight loss response. We hypothesized that baseline multiomic features, including DNA methylation (DNAme), metabolomics, and gut microbiome, would be predictive of short‐term changes in body weight and other clinical outcomes within a comprehensive weight loss intervention.MethodsHealthy adults with overweight or obesity (n = 62, age 18‐55 years, BMI 27‐45 kg/m2, 75.8% female) participated in a 1‐year behavioral weight loss intervention. To identify baseline omic predictors of changes in clinical outcomes at 3 and 6 months, whole‐blood DNAme, plasma metabolites, and gut microbial genera were analyzed.ResultsA network of multiomic relationships informed predictive models for 10 clinical outcomes (body weight, waist circumference, fat mass, hemoglobin A1c, homeostatic model assessment of insulin resistance, total cholesterol, triglycerides, C‐reactive protein, leptin, and ghrelin) that changed significantly (P < 0.05). For eight of these, adjusted R2 ranged from 0.34 to 0.78. Our models identified specific DNAme sites, gut microbes, and metabolites that were predictive of variability in weight loss, waist circumference, and circulating triglycerides and that are biologically relevant to obesity and metabolic pathways.ConclusionsThese data support the feasibility of using baseline multiomic features to provide insight for precision nutrition–based weight loss interventions.
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Low-Dose Olanzapine Plus Granisetron and Dexamethasone for Carboplatin-Induced Nausea and Vomiting in Patients with Thoracic Malignancies: A Prospective Multicenter Phase II Trial
Authors: Sakai Chizuru , Shimokawa Mototsugu , Iihara Hirotoshi , Fujita Yukiyoshi , Ikemura Shinnosuke , Hirose Chiemi , Kotake Mie , Funaguchi Norihiko , Gomyo Takenobu , Imai Hisao , Hakamata Jun , Kaito Daizo , Minato Koichi , Arai Takahiro , Kawazoe Hitoshi , Suzuki Akio , Ohno Yasushi , Okura Hiroyuki 
Published: April 2021

Abstract

Background
Olanzapine is an inexpensive and durable agent for the treatment of chemotherapy-induced nausea and vomiting and is also superior to neurokinin-1 receptor antagonists in the control of nausea. This study aimed to investigate the efficacy and safety of a low dose of 5 mg olanzapine plus granisetron and dexamethasone for treatment of carboplatin (CBDCA)-induced nausea and vomiting in patients with thoracic malignancies.

Materials and Methods
We conducted a prospective, open-label, single-arm, multicenter, phase II trial in four centers in Japan. Registered patients were scheduled to receive area under the curve (AUC) ≥5 mg/mL per minute of CBDCA and had never received moderately to highly emetogenic chemotherapy. Patients received olanzapine 5 mg/day orally after supper for 4 days, in combination with granisetron and dexamethasone. Primary endpoint was complete response (CR; no emesis and no use of rescue medication) rate during the overall phase (0–120 hours).

Results
Between February 2018 and June 2020, 51 patients were enrolled, and 50 patients were evaluated. The CR rates in the overall (0–120 hours), acute (0–24 hours), and delayed phases (24–120 hours) were 94.0%, 100%, and 94.0%, respectively. No grade 3 or higher adverse effects of olanzapine were observed.

Conclusion
Prophylactic antiemetic therapy with a low dose of 5 mg olanzapine plus granisetron and dexamethasone showed durable efficacy with an acceptable safety profile. This three-drug combination appears to be a reasonable treatment approach in patients with thoracic malignancies receiving an AUC ≥5 mg/mL per minute of CBDCA-based regimen. Clinical trial identification number: UMIN000031267.

Implications for Practice
The results of this phase II trial indicated that the prophylactic administration of low-dose of 5 mg olanzapine combined with granisetron and dexamethasone has promising activity with acceptable safety profile in patients with thoracic malignancy receiving high-dose carboplatin chemotherapy.
Damping and mechanical properties of carbon nanotube solvent‐free nanofluids‐filled epoxy nanocomposites
Authors: Wang Yudeng , Wang Dechao , He Zhongjie , Yao Dongdong , Zheng Yaping 
Published: April 2021

AbstractCarbon nanotube‐filled epoxy nanocomposite is a promising material that can be used as the structural damping materials. To improve the dispersity of multiwalled carbon nanotube (MWNT) and adjust the interface strength, two kinds of MWNT‐based nanofluids were synthesized by surface chemical modification. Then, the nanofluids prepared were added into epoxy matrix to obtain nanocomposites, respectively. The mechanical and damping properties of nanocomposites were investigated. It is found that both the interface strength and dispersion cause significant influence on the mechanical and damping properties. Importantly, the introduction of nanofluids with excellent dispersity and weak interface strength can simultaneously enhance the damping properties and mechanical properties of epoxy. When 0.5 wt% MWNT was added to the epoxy resin matrix, the bending strength, bending modulus and impact strength of nanofluids‐filled epoxy nanocomposites increased by more than 10%, 14%, and 40%, respectively. The loss factor of nanofluids‐filled epoxy nanocomposites is higher than pure epoxy at the glassy state, and it increased with the increasing of the nanofluids content.