bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of IgG antibodies kinetics after severe and critical COVID‐19
Authors: De Greef Julien , Scohy Anaïs , Zech Francis , Aboubakar Frank , Pilette Charles , Gerard Ludovic , Pothen Lucie , Yildiz Halil , Belkhir Leïla , Yombi Jean Cyr 
Published: May 2021

AbstractThe kinetics of IgG antibodies after coronavirus disease 2019 (COVID‐19) remain poorly understood. We investigated factors influencing severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) IgG antibody levels and time to seronegativation during the follow‐up of severe and critically ill patients. We retrospectively reviewed serological evaluations drawn during the follow‐up of severe or critical laboratory‐proven COVID‐19 patients hospitalized at a large academic hospital. Specific IgG titers were measured using a chemiluminescent assay targeting anti‐spike and anti‐nucleocapsid protein IgG. The influence of time, demographic factors, clinical and paraclinical characteristics, and COVID‐19 therapeutics on IgG levels were assessed through linear regression using a mixed‐effect model, and delay until IgG negativation through a Weibull regression model. The cohort included 116 patients with a total of 154 IgG measurements drawn at a median of 79 days after diagnosis. IgG antibodies were increased with age (p = 0.005) and decreased significantly over time (p = 0.0002). Using elapsed time and age as covariates, we demonstrated higher IgG levels in patients with a higher body mass index (BMI) (p = 0.0026) and lower IgG levels in immunocompromised patients (p = 0.032). A high BMI was further found to delay and immunodeficiency to hasten significantly seronegativation, whereas no significant effect was observed with corticosteroids. These data highlight the waning over time of IgG antibodies after severe or critical COVID‐19. Age, BMI, and immunosuppression also appear to influence the IgG kinetics, while short‐term corticotherapy does not. Those data improve the understanding of SARS‐CoV‐2 serology while further research should determine the determinants of long‐term seroprotection.
What Survivorship Means to Liver Transplant Recipients: Qualitative Groundwork for a Survivorship Conceptual Model
Authors: Lieber Sarah R. , Kim Hannah P. , Baldelli Luke , Nash Rebekah , Teal Randall , Magee Gabrielle , Loiselle Marci M. , Desai Chirag S. , Lee Simon C. , Singal Amit G. , Marrero Jorge A. , Barritt A. Sidney , Evon Donna M. 
Published: May 2021

Survivorship is a well‐established concept in the cancer care continuum with a focus on disease recurrence, quality of life, and the minimization of competing risks for mortality; however, survivorship has not been well studied in liver transplantation (LT). We investigated what survivorship means to LT patients and identified motivations and coping strategies for overcoming challenges after LT. A total of 20 in‐depth home interviews were conducted among adults 3 to 6 months after LT. Interviews were conducted by trained qualitative research experts and coded and analyzed using an inductive approach. A majority of LT recipients (75%) identified themselves as survivors. Integral to the definition of survivorship was overcoming hardship (including experiences on the waiting list) and the unique experience of being given a “second chance” at life. Motivations to survive included a new chance at life (55%), family (40%), spirituality/faith (30%), and fear of rejection (15%). LT recipients and caregivers identified multiple strategies to cope with post‐LT challenges, including relying on a large network of community, spiritual, and virtual support. These findings informed a conceptual model of LT survivorship based on socioecological theory, which identified the following variables influencing survivorship: (1) pretransplant experiences, (2) individual attributes and challenges, (3) interpersonal relationships with caregivers and other social support, (4) community relationships, and (5) large‐scale factors including neighborhood and financial issues. LT recipients identified themselves as survivors, and post‐LT identities were greatly influenced by pre‐LT experiences. These perspectives informed an in‐depth conceptual model of survivorship after transplantation. We identified sources of motivation and coping strategies used in LT recovery that could be targets of survivorship interventions aimed at improving post‐LT outcomes.
Germline and somatic mutations in the pathology of pineal cyst: A whole‐exome sequencing study of 93 individuals
Authors: Yan Yuanqing , Martinez Rebecca , Rasheed Maria N. , Cahal Joshua , Xu Zhen , Rui Yanning , Qualmann Krista J. , Hagan John P. , Kim Dong H. 
Published: May 2021

AbstractBackgroundPineal cyst is a benign lesion commonly occurring in people of any age. Until now, the underlying molecular alterations have not been explored.MethodsWe performed whole exome sequencing of 93 germline samples and 21 pineal cyst tissue samples to illustrate its genetic architecture and somatic mutations. The dominant and recessive inheritance modes were considered, and a probability was calculated to evaluate the significance of variant overrepresentation.ResultsBy analyzing pineal cyst as a Mendelian disease with a dominant inheritance pattern, we identified 42,325 rare germline variants, and NM_001004711.1:c.476A>G was highly enriched (FDR<0.2). By analyzing it as a recessive disorder, we identified 753 homozygous rare variants detected in at least one pineal cyst sample each. One STIM2 rare variant, NM_001169117.1:c.1652C>T, was overrepresented (FDR<0.05). Analyzing at a gene‐based level, we identified a list of the most commonlymutated germline genes, including POP4, GNGT2 and TMEM254. A somatic mutation analysis of 21 samples identified 16 variants in 15 genes, which mainly participated in the biological processes of gene expression and epigenetic regulation, immune response modulation, and transferase activity.ConclusionThese molecular profiles are novel for this condition and provide data for investigators interested in pineal cysts.
Hydrodistention does not alter bladder gene expression profiles in patients with non‐Hunner lesion interstitial cystitis/bladder pain syndrome
Authors: Xu Raymond , Schachar Jeffrey , Evans Robert J. , Matthews Catherine A. , Badlani Gopal , Walker Stephen J. 
Published: May 2021

AbstractAimsGene expression profiling of bladder biopsies in patients with interstitial cystitis/bladder pain syndrome (IC/BPS), typically obtained following therapeutic bladder hydrodistention (HOD), is used to improve our understanding of molecular phenotypes. The objective of this study was to determine if the HOD procedure itself impacts the biopsy gene expression profile and, by extension, whether biopsies from non‐HOD bladders are appropriate controls.MethodsBladder biopsies were obtained just before HOD and immediately following HOD from 10 consecutively recruited IC/BPS patients undergoing therapeutic HOD. Biopsies were also obtained from four non‐IC/BPS patients who did not undergo HOD (controls). Total RNA was isolated from each of the 24 samples and used to query whole‐genome microarrays. Differential gene expression analysis was performed to compare expression profiles of IC/BPS biopsies before and after HOD, and between IC/BPS and control biopsies.ResultsPrincipal component analysis revealed complete separation between gene expression profiles from IC/BPS and control samples (q ≤ 0.05) and while IC/BPS samples before and after HOD showed no significant differences in expressed genes, 68 transcripts were found to be significantly different between IC/BPS and control samples (q ≤ 0.05).ConclusionsThe bladder HOD procedure itself does not significantly change gene expression within the IC/BPS patient bladder, a finding that provides evidence to support the use of biopsies from non‐IC/BPS patients that have not undergone HOD as controls for gene expression studies.
A qualitative study on shared decision‐making of patients with chronic kidney disease
Authors: Ho Ya‐Fang , Chen Yu‐Chi , Li I‐Chuan 
Published: May 2021

AbstractAimThis study aims to explore the change process among chronic kidney disease patients in shared decision‐making.DesignQualitative research is the design applied.MethodOriginal transcripts from an earlier study involving a purposive sample of 31 patients with chronic kidney disease provided a source of information. The data collection was conducted from August 2017–January 2018. Data analysis applied the thematic analysis method.ResultsThree themes were identified: from avoidance to being forced to accept, decision‐making process of action and facilitating factors. After making the psychological adjustments necessary for undergoing dialysis treatment, participants experience the process of decision‐making action. The improvement of knowledge and ability increases the patient's self‐determination consciousness and strengthens confidence in decision‐making. The nurse and the patient's family are both important facilitating factors, and they assist through the entire SDM process.
Lost in Transition? Thoughts on Retirement, Part 2. “Should I Stay or Should I Go Now?”
Authors: Beltran-Bless Ana-Alicia , Vandermeer Brent , Paterson Alexander , Gunstone Ian , Kaizer Leonard , Arnaout Angel , Vandermeer Lisa , Clemons Mark 
Published: May 2021

Abstract
Although it is accepted that oncologists should plan for a future beyond full-time oncology, there is little practical guidance for a successful transition into retirement. Previously, we provided strategies for various aspects of retirement planning. However, this became significantly more complicated as we face newer issues such as the COVID-19 pandemic, the move to virtual patient care, greater awareness of burnout, and the increasing burden of regulatory issues such as the electronic medical record. It is evident that more prospective information is needed to guide oncologists in planning their retirement.
Synthesis of Tetra‐Substituted Trifluoromethyl‐3,1‐Benzoxazines by Transition‐Metal‐Catalyzed Decarboxylative Cyclization of N‐Benzoyl Benzoxazinones
Authors: Uno Hiroto , Fujimoto Daichi , Harada Kyosuke , Tanaka Chika , Shibata Norio 
Published: May 2021

AbstractInvited for this month's cover are the group of Norio Shibata at Nagoya Institute of Technology (Japan). The cover picture is inspired by the diversity in the ocean also in cyberspace. In the present research, we can synthesize diverse heterocyclic molecules having a trifluoromethyl group in a single step by changing the N‐substitution. You can see more variations of trifluoromethyl heterocycles in several papers by our group. Read the full text of their Communication at 10.1002/open.202000360.
Intestinal smooth muscle aberrations in pancreatic cancer patients with sarcopenia
Authors: Vaes Rianne D.W. , Welbers Tessa T.J. , van Dijk David P.J. , Rennspiess Dorit , zur Hausen Axel , Damink Steven W.M. Olde , Rensen Sander S. 
Published: May 2021

AbstractBackgroundCancer cachexia is characterized by impaired function of skeletal and cardiac muscle. Smooth muscle is abundantly present in the body and critical for the function of the gastrointestinal tract. Given the frequently reported gastrointestinal symptoms in cancer patients, we hypothesized that the smooth musculature could be compromised in cancer patients with sarcopenia.MethodsFull‐thickness jejunal tissue sections from 57 pancreatic cancer patients were analysed by picrosirius red stains and immunohistochemistry for α‐smooth muscle actin (α‐SMA), smoothelin, and CD117 (c‐kit). Muscle wall thickness, contractile marker expression, and collagen deposition were quantified. Patients were assigned to a sarcopenia or non‐sarcopenia group based on their skeletal muscle index.ResultsIntestinal smooth muscle wall thickness did not differ between the sarcopenia and non‐sarcopenia group (1,661 ± 125.0 vs. 1,439 ± 93.5 μm, P = 0.41). Whereas α‐SMA staining intensity was similar in both groups, staining intensity of smoothelin, a key marker of the contractile smooth muscle cell phenotype, was reduced (143.0 ± 22.6 vs. 125.4 ± 29.3 arbitrary units, P = 0.02) in sarcopenic patients. The distribution of CD117+ interstitial cells of Cajal was similar in both groups, but pronounced collagen deposition around the myenteric plexus was more often observed in patients with sarcopenia (P = 0.04).ConclusionsThese data suggest that cancer cachexia is not only associated with skeletal and cardiac muscle wasting, but also affects the intestinal smooth musculature. Reduced contractile smooth muscle marker expression and fibrosis around the myenteric plexus suggest that both contractile function of smooth muscle cells and regulation of their contractile functionality could be compromised.
Periodic event‐triggered control with multisource disturbances and quantized states
Authors: Zhao Mingyuan , Zheng Shiqi , Ahn Choon Ki , Zong Xiaofeng , Zhang Chuan‐Ke 
Published: May 2021

AbstractThis study investigates periodic event‐triggered (PET) output‐feedback control method for nonlinear systems with quantized states and multisource disturbances. Based on a PET extended state observer, a novel PET composite control method is proposed. It not only can deal with the deterministic and stochastic disturbances but also can handle the quantization in the data transmission process. A PET extended state observer is used to simultaneously estimate the states and the disturbances. Moreover, both the static and dynamic event‐triggered conditions are considered. Simulations and an experiment on a direct current brush motor are conducted to validate the proposed approach.
Using drones to reduce human disturbance while monitoring breeding status of an endangered raptor
Authors: Gallego Diego , Sarasola José H. 
Published: May 2021

AbstractIn birds, obtaining information related to nest occupancy, offspring status or breeding success is essential for population monitoring, particularly for species of conservation concern. Traditionally, nest monitoring demands a lot of time and effort in order to gather accurate information and avoiding nest disturbance. Instead, Unmanned Aerial Vehicles (UAVs, hereafter drones) present an alternative to traditional methods, but few studies have been done measuring their influence on birds’ behavior and reproductive success. We addressed the utility of drones equipped with an on‐board camera in examining nesting status of the endangered Chaco Eagle Buteogallus coronatus in semiarid environments of central Argentina, as well as the degree of disturbance of drone flights to individuals. We performed 76 drone flights at 41 Chaco Eagle nests registering flight duration, tree height, nest relative height and pilot proximity to nest. Of those, 38 flights were done over occupied nests where we recorded adult behavior. Before drone took off, most adult eagles remained in the nests or in the surroundings (<100 m away), particularly during the incubation period and in tall trees. During drone flights, only one adult flew as a response to drone flights. The rest of them remained vigilant or emitted alarm calls while incubating or perched on the nest platform. No attack toward drones was registered. The use of drones for monitoring Chaco Eagle’s nests significantly reduced levels of disturbance when compared with traditional methods where all adults flew away during climbing. Additionally, this method was almost three times faster in comparison to traditional climbing (performed at the end of the reproductive season) and had no negative effects on reproductive success of Chaco Eagles. Although responses to drones could be species‐specific, our results encourage researchers to consider and test the use of drones as a less disturbing and rapid method to monitor breeding raptor populations.
Psychosocial Aspects of Obesity in Adults with Psoriasis: A Systematic Review
Authors: Pavlova N.T. , Kioskli K. , Smith C. , Picariello F. , Rayner L. , Moss-Morris R. 
Published: May 2021

Abstract

Background
Excess weight is a common (30%–40%) multifactorial concern that remains understudied in adults with psoriasis.

Objectives
This systematic review aimed to synthesise the evidence on the psychosocial factors associated with body weight in psoriasis and to use these findings to inform clinical practice. The review was registered with PROSPERO (registration number: CRD42020201138).

Methods
Electronic databases, related reviews and associated reference lists were searched. Observational and experimental studies reporting on the relationship of psychosocial factors to weight-related outcomes in adults with body mass index (BMI) of ≥30 kg/m2 and psoriasis were eligible. The methodological quality of the included studies was assessed using the Critical Appraisal Skills Programme (CASP).

Results
Eighteen studies were included in the review, the majority of which (n = 16) examined cross-sectional associations between psychosocial factors and weight outcomes. Although the strengths of the associations were heterogeneous, most studies confirmed the positive association between high BMI and increased reports of depression and anxiety, impaired quality of life, deteriorated sleep quality, sexual dysfunction, and daily functioning issues. Only four studies were rated as high quality.

Conclusions
The current evidence of the association between psychosocial factors and weight-related outcomes is largely cross-sectional with unclear directionality of causality. Longitudinal studies are needed to examine the replicability and generalisability of the examined obesity-related psychosocial factors in psoriasis. Theoretical exploration of subgroup differences and similarities may pave the way towards intervention personalisation, and ultimately, improved patient outcomes.
Extraction Behavior of Germanium in Kelex 100 and LIX 63 Systems
Authors: Fleitlikh Isaac Yu. , Grigorieva Natalya A. , Logutenko Olga A. 
Published: May 2021

AbstractIn this study, 7‐(4‐ethyl‐1‐methyloctyl)‐8‐quinolinol (HL, Kelex 100) and 5,8‐diethyl‐7‐hydroxydodecane‐6‐oxime (LIX 63, HA) were employed to recover Ge(IV) from sulfuric acid solutions in the presence of singly charged inorganic anions. Under comparable conditions, the germanium extraction efficiency was in the order Cl−<NO3−<I−<<CNS−. In the presence of thiocyanate ion, the germanium complexes extracted by Kelex 100 and LIX 63 were [GeL3]+[CNS]− and Ge(OH)2A(CNS) respectively. An increase in the pH values was shown to lead to a decrease in the extraction of Ge(IV) with HL from sulfate‐thiocyanate solutions. At pH values of ≥5.9, the degree of germanium recovery is <2.0 % which makes stripping with alkaline aqueous solutions possible. When adding bis(2,4,4‐trimethylpentyl)acid (HR, CYANEX 301) to the HL and HA mixture, a significant synergistic effect takes place. The composition of the extracted complex with Kelex 100 was found to be [GeL3]+[R−]. The use of extraction systems based on both Kelex 100 and LIX 63, and on their mixture with CYANEX 301 in the presence of thiocyanate ion is of undoubted practical interest for hydrometallurgical processes to recover germanium..
Synthesis and Application of Asymmetry Diphenylketone Photoinitiators
Authors: Zhao Ziren , Song Lu , Liu Feng , Zhang Bianxiang 
Published: May 2021

AbstractIn this study, a series of novel functionalized benzophenone derivatives were elaborately designed and efficiently synthesized with low‐cost raw materials through a simple esterification reaction of heteroatoms/heterocycles substituted hydroxybenzophenone with acyl chloride. The chemical structures of the compounds were carefully characterized by proton nuclear magnetic resonance (1H NMR), carbon nuclear magnetic resonance (13C NMR), and high‐resolution mass spectrometry (HRMS). All compounds exhibited a strong and broad UV‐visible light absorption spectrum in comparison with BP. Moreover, owing to the breaking symmetry and higher molecular weight, these compounds displayed efficient photoinitiating activity and low mobility and self‐quenching as free radical photoinitiators. The resulting films exhibited much better mechanical properties compared with commercially available BP and Irgacure 184, implying potential application in industrial UV curing.
Mesoporous organosilica nanoparticles: Degradation strategies and application in tumor therapy
Authors: Guan Lei , Chen Jiajie , Tian Zhengfang , Zhu Min , Bian Yuhai , Zhu Yufang 
Published: May 2021

AbstractBiodegradation is a crucial issue for silica‐based mesoporous nanoparticles that is related to the biosafety in tumor therapy. Nowadays, mesoporous silica nanoparticles (MSNs) have been intensively developed to construct multifunctional nanosystems for tumor therapy due to their biocompatibility, high drug loading capacity and easy functionalization; however, their biodegradation is relatively slow and still under debate. To improve the biodegradability of silica‐based mesoporous nanoparticles, a simple organic‐inorganic hybridization strategy to synthesize mesoporous organosilica nanoparticles (MONs) has been successfully developed. By hybridizing the silica framework (–Si–O–Si–) with stimuli‐sensitive organic moieties to form organic‐inorganic network (–Si–R–Si–, R: organic moiety), when exposed to the stimuli environment, the breakdown of the organic‐inorganic network could accelerate the degradation of MONs, which is great promising for MONs as a multifunctional therapeutic nanoplatform in tumor therapy. This review aims to summarize the degradation strategies for MONs to improve biodegradability in recent years, and highlight the potential applications of MONs in tumor therapy. Finally, we also discuss the challenges of MONs for tumor therapy in future clinical translation.
Automatic segmentation to characterize anthropometric parameters and cardiovascular indicators in children
Authors: Goroso Daniel Gustavo , Fraga Alvaro , Macedo Michel , Fernanda de Miranda Rodrigues Carla , Mendes de Oliveira Silva Bruno , Watanabe William Tsutomu , Pereira da Silva Diego , Rodrigues da Silva Robson , Puglisi José Luis , Marcin James , Dharmar Madan 
Published: May 2021

AbstractA new predictive model to classify childhood obesity was implemented using machine learning techniques. The first step was to calculate the most relevant anthropomorphic and cardiovascular parameters of 187 children through principal component analysis (PCA) and cluster classification. Then Naïve‐Bayes method classified these children into six groups using anthropometric Z Score, measurements of abdominal obesity, and arterial pressure: Group I (20.32% of total): composed mainly by accentuated malnutrition and malnutrition children; Group II (36.36%): composed primarily by eutrophic children; Group III (21.4%): constituted by eutrophic plus overweight children; Group IV (14.97%): comprised mainly by overweight and obese children; Group V (5.34%): Obese and overweight children; and Group VI (1.6%): obese at risk children. From Group II to VI, the proportion of pre‐hypertensive and hypertensive children increased monotonically from 5 to 33%. This classification modes was tested on 66 children that were not originally included with a success rate of 97%. This predictive model will facilitate future longitudinal studies of obesity in children and will help plan interventions and evaluations of their results.This article is categorized under:
Algorithmic Development > Biological Data Mining