bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review of carbohydrate-based microneedles: current status and future prospects
Authors: Bhadale Rupali S. , Londhe Vaishali Y. 
Published: July 2021

AbstractMicroneedles (MNs) are minimally invasive tridimensional biomedical devices that bypass the skin barrier resulting in systemic and localized pharmacological effects. Historically, biomaterials such as carbohydrates, due to their physicochemical properties, have been used widely to fabricate MNs. Owing to their broad spectrum of functional groups, carbohydrates permit designing and engineering with tunable properties and functionalities. This has led the carbohydrate-based microarrays possessing the great potential to take a futuristic step in detecting, drug delivery, and retorting to biologicals. In this review, the crucial and extensive summary of carbohydrates such as hyaluronic acid, chitin, chitosan, chondroitin sulfate, cellulose, and starch has been discussed systematically, using PRISMA guidelines. It also discusses different approaches for drug delivery and the mechanical properties of biomaterial-based MNs, till date, progress has been achieved in clinical translation of carbohydrate-based MNs, and regulatory requirements for their commercialization. In conclusion, it describes a brief perspective on the future prospects of carbohydrate-based MNs referred to as the new class of topical drug delivery systems.
The large N limit of orbifold vertex operator algebras
Authors: Gemünden Thomas , Keller Christoph A. 
Published: July 2021

AbstractWe investigate the large N limit of permutation orbifolds of vertex operator algebras. To this end, we introduce the notion of nested oligomorphic permutation orbifolds and discuss under which conditions their fixed point VOAs converge. We show that if this limit exists, then it has the structure of a vertex algebra. Finally, we give an example based on $$\mathrm {GL}(N,q)$$

GL
(
N
,
q
)

for which the fixed point VOA limit is also the limit of the full permutation orbifold VOA.
Existence of quasi-periodic responses in quasi-periodically forced nonlinear mechanical systems
Authors: Breunung Thomas 
Published: July 2021

AbstractForced responses of mechanical systems are crucial design and performance criteria. Hence, their robust and reliable calculation is of vital importance. While numerical computation of periodic responses benefits from an extensive mathematical basis, the literature for quasi-periodically forced systems is limited. More specifically, the absence of applicable and general existence criterion for quasi-periodic orbits of nonlinear mechanical systems impedes definitive conclusions from numerical methods such as harmonic balance. In this work, we establish a general existence criterion for quasi-periodically forced vibratory systems with nonlinear stiffness terms. Our criterion does not rely on any small parameters and hence is applicable for large response and forcing amplitudes. On explicit numerical examples, we demonstrate how our existence criterion can be utilized to justify subsequent numerical computations of forced responses.
Parametric vibrations of graphene sheets based on the double mode model and the nonlocal elasticity theory
Authors: Awrejcewicz Jan , Kudra Grzegorz , Mazur Olga 
Published: July 2021

AbstractParametric vibrations of the single-layered graphene sheet (SLGS) are studied in the presented work. The equations of motion govern geometrically nonlinear oscillations. The appearance of small effects is analysed due to the application of the nonlocal elasticity theory. The approach is developed for rectangular simply supported small-scale plate and it employs the Bubnov–Galerkin method with a double mode model, which reduces the problem to investigation of the system of the second-order ordinary differential equations (ODEs). The dynamic behaviour of the micro/nanoplate with varying excitation parameter is analysed to determine the chaotic regimes. As well the influence of small-scale effects to change the nature of vibrations is studied. The bifurcation diagrams, phase plots, Poincaré sections and the largest Lyapunov exponent are constructed and analysed. It is established that the use of nonlocal equations in the dynamic analysis of graphene sheets leads to a significant alteration in the character of oscillations, including the appearance of chaotic attractors.
Accounting for non-normal distribution of input variables and their correlations in robust optimization
Authors: Nejadseyfi O. , Geijselaers H. J. M. , Atzema E. H. , Abspoel M. , van den Boogaard A. H. 
Published: July 2021

AbstractIn this work, metamodel-based robust optimization is performed using measured scatter of noise variables. Principal component analysis is used to describe the input noise using linearly uncorrelated principal components. Some of these principal components follow a normal probability distribution, others however deviate from a normal probability distribution. In that case, for more accurate description of material scatter, a multimodal distribution is used. An analytical method is implemented to propagate the noise distribution via metamodel and to calculate the statistics of the response accurately and efficiently. The robust optimization criterion as well as the constraints evaluation are adjusted to properly deal with multimodal response. Two problems are presented to show the effectiveness of the proposed approach and to validate the method. A basketball free throw in windy weather condition and forming of B-pillar component are presented. The significance of accounting for non-normal distribution of input variables using multimodal distributions is investigated. Moreover, analytical calculation of response statistics, and adjustment of the robust optimization problem are presented and discussed.
The SN2 reaction and its relationship with the Walden inversion, the Finkelstein and Menshutkin reactions together with theoretical calculations for the Finkelstein reaction
Authors: Alkorta Ibon , Elguero José 
Published: July 2021

AbstractThis communication gives an overview of the relationships between four reactions that although related were not always perceived as such: SN2, Walden, Finkelstein, and Menshutkin. Binary interactions (SN2 & Walden, SN2 & Menshutkin, SN2 & Finkelstein, Walden & Menshutkin, Walden & Finkelstein, Menshutkin & Finkelstein) were reported. Carbon, silicon, nitrogen, and phosphorus as central atoms and fluorides, chlorides, bromides, and iodides as lateral atoms were considered. Theoretical calculations provide Gibbs free energies that were analyzed with linear models to obtain the halide contributions. The M06-2x DFT computational method and the 6-311++G(d,p) basis set have been used for all atoms except for iodine where the effective core potential def2-TZVP basis set was used. Concerning the central atom pairs, carbon/silicon vs. nitrogen/phosphorus, we reported here for the first time that the effect of valence expansion was known for Si but not for P. Concerning the lateral halogen atoms, some empirical models including the interaction between F and I as entering and leaving groups explain the Gibbs free energies.
Ten-year experience of an outpatient clinic for CKD-5 patients with multidisciplinary team and educational support
Authors: Terlizzi Vincenzo , Sandrini Massimo , Vizzardi Valerio , Tonoli Mattia , Facchini Annalisa , Manili Luigi , Zeni Letizia , Cancarini Giovanni 
Published: July 2021

Abstract
Purpose
To analyze the results of an outpatient clinic with a multidisciplinary team and educational support for patients with late-stage CKD (lsCKD), to check its possible effect on their outcomes.

Methods
Longitudinal cohort study on patients followed up in the MaReA (Malattia Renale Avanzata = CKD5) outpatient clinic at ASST Spedali Civili of Brescia from 2005 to 2015 for at least six months. Trajectory of renal function over time has been evaluated only in those patients with at least four estimations of eGFR before referring to MaReA.

Results
Seven hundred and six patients were enrolled, their mean age was 72 ± 14 years, 59% were males. At the end of the study, 147 (21%) were still on MaReA, 240 (34%) on dialysis, 92 (13%) on very low-protein diet (VLPDs), 13 (2%) on pre-hemodialysis clinic, 23 (3%) improved renal function, 10 (1%) transplanted, 62 (9%) transferred/lost to follow-up, and 119 (17%) died. Optimal dialysis start (defined as start with definitive dialysis access, as an out-patient and without lsCKD complications) occurred in 180/240 (75%) patients. The results showed a slower eGFR decrease during MaReA follow-up compared to previous renal follow-up: − 2.0 vs. − 4.0 mL/min/1.73 m2 BSA/year (p < 0.05), corresponding to a median delay of 17.7 months in dialysis start in reference to our policy in starting dialysis. The patient cumulative survival was 75% after 24 months and 25% after 70. Limitations: (1) lack of a control group, (2) one-center-study, (3) about all patients were Caucasians.

Conclusion
The follow-up of lsCKD patients on MaReA is associated with an optimal and delayed initiation of dialysis.
A systematic literature review concerning the different interpretations of the role of sustainability in project management
Authors: Friedrich Kevin 
Published: July 2021

AbstractThe concept of sustainable development is widely accepted as one of the most important topics of our time. Although significant research has already been conducted within the field of integrating sustainability into project management, different interpretations of the role of sustainability appear. This is a major issue for the scientific community, as due to these varying interpretations it is difficult to put publications into context; accordingly, it might lead to communication issues within the community. With this research study we want to help solve this issue. We conduct a systematic literature review and identify 293 relevant publications. Using a synthesis approach based on grounded theory, we define three different categories of interpretations of the role of sustainability in the current state of research. The literature is then assigned back to these interpretations. Following this approach we are not only able to review the development of each interpretation over time, but also to identify that many publications contain multiple interpretations. Based on our findings, we give recommendations for the reflection of the existing literature, the writing of new publications and communication in the research field. We also redefine the concept of ‘sustainable project management’ based on a major theoretical characteristic we synthesise during our grounded theory approach to give guidance to future researchers.
Preventing violence in youth sport and physical education: the NOVIS proposal
Authors: Vitali Francesca , Conte Salvatore 
Published: July 2021

Abstract
Background
Violence in sport, both on and off the field, has been conceived as a main social problem that needs to be prevented.

Aims
The purpose of this paper is to present in the ‘No Violence in Sport’ (NOVIS) project framework, a modular training model, some recommendations and tools that can be implemented in youth sport and physical education (PE) to prevent violence.

Methods
A modular training model summarized in a NOVIS methodological guide designed for coaches and PE teachers aimed at raising awareness on preventing violence and developing specific didactic skills to contrast violence is presented. Didactic recommendations to create a mastery (task-involving) motivational climate in youth sport and PE, interactive didactic methodologies and inclusion are the key elements of the modular training model. In addition, some multimedia didactic tools (i.e., sport chart, logbooks, cooperative games, and videos) are also presented.

Conclusions
The main aim of the NOVIS project was to develop teaching methodologies and tools focused at preventing violence in youth sport and PE. Future research is needed to implement the modular training model and to test it, evaluating its efficacy, expanding its aims, and adapting it to specific contexts and countries.
Assumptions and confidence of others: the impact of socio-cognitive information on metacognitive self-regulation
Authors: Schnaubert Lenka , Krukowski Simon , Bodemer Daniel 
Published: July 2021

AbstractSelf-regulated learning rarely happens in isolation and although there is a wide range of evidence that socio-cognitive information may impact decision making and learning, its role in metacognitive self-regulation remains understudied. Thus, we investigated how socio-cognitive information on assumptions and confidence in assumptions of an unknown other in a learning setting affects (1) changes in assumptions (i.e., convergence towards other), (2) perception of the other’s competence, and (3) the search for information (i.e., metacognitive and conflict-based regulation). In our empirical study, N = 60 students first read texts, then judged statements as being true or false and stated their confidence in these assumptions on an integrated confidence/answer scale, were then confronted with bogus information on the supposed answers of another learner (computer generated), and were then asked to (1) re-state their assumptions including confidence judgment, (2) judge the other’s competence, and (3) decide what statements they wanted additional information on. Results showed that learners (1) converged towards the other learner, (2) judged the other’s competence in accordance with the other’s stated confidence, and (3) regulated their learning based on their own (adjusted) confidence rather than on the presence or absence of socio-cognitive conflicts. This suggests that socio-cognitive information can affect how learners metacognitively evaluate own assumptions and thus impact self-regulatory processes, but also that confidence of others affects their perceived competence. Although the direct impact of socio-cognitive conflicts on regulatory processes remains unclear, this study fosters our understanding of self-regulated learning processes within social contexts.
Distribution profiles of diphenhydramine and lidocaine in scalp, axillary, and pubic hairs measured by micro-segmental hair analysis: good indicator for discrimination between administration and external contamination of the drugs
Authors: Kuwayama Kenji , Miyaguchi Hajime , Kanamori Tatsuyuki , Tsujikawa Kenji , Yamamuro Tadashi , Segawa Hiroki , Okada Yuki , Iwata Yuko T. 
Published: July 2021

Abstract
Purpose
Drug distribution in scalp hair can provide historical information about drug use, such as the date and frequency of drug ingestion. We previously developed micro-segmental hair analysis, which visualizes drug distribution at 0.4-mm intervals in individual hairs. The present study examines whether the distribution profiles of drugs can be markers for the administration or external contamination of the drugs using scalp, axillary, and pubic hairs.

Methods
A single dose of anti-itch ointment containing diphenhydramine (DP) and lidocaine (LD) was topically applied to the axillary or pubic areas of two volunteers; DP was also orally administered; and LD was intra-gingivally injected. Scalp, axillary, and pubic hairs were assessed using our micro-segmental analysis.

Results
The localization of DP and LD differed within individual scalp hair strands, implying DP and LD were predominantly incorporated into scalp hair via the bloodstream and via sweat/sebum, respectively, showing double-peak profiles. However, DP and LD were distributed along the shafts of axillary and pubic hairs without appearance of the double-peak profiles when the ointment had been applied to the axillary and pubic areas. The distributions of DP and LD in scalp hairs did not significantly differ according to administration routes, such as oral administration, gingival injection, and topical application.

Conclusions
Micro-segmental analysis revealed differences in the distribution profiles of drugs in hairs, and distinguished hairs with and without external contamination. These findings will be useful for understanding of the mechanism of drug uptake into hair and for estimating the circumstances for a drug use.
Effect of Surface Oxides on the Melting and Solidification of 316L Stainless Steel Powder for Additive Manufacturing
Authors: Yang Xinliang , Gao Feng , Tang Fengzai , Hao Xinjiang , Li Zushu 
Published: July 2021

Abstract
Surface oxidation of metallic powders may significantly affect their melting and solidification behavior and limit their service life in the additive manufacturing (AM) process. In the present work, three levels of surface oxide concentration were prepared on AM-grade 316L stainless steel powders, and their melting and solidification behavior was systematically studied through in-situ observation, advanced characterization, phase-field modeling, and theoretical analysis. Si, Mn, and Cr participated in the oxidation reaction in powder with low and medium oxygen contents, whereas Fe was involved in the oxidation reaction for the powder samples with high oxygen content. A higher full melting temperature is observed to lead to an integrated melt pool in the melting of the highly oxidized powder, which is due to the reduced permeability produced by the oxide cage effect. For the droplet samples prepared from high oxygen powders, the inclusion with increased volume fraction and coarsened size is attributed to the agglomeration of inclusion particles with the residual oxide in the melt. In the high oxygen powder fusion scenario, an undesired coarse columnar grain structure with a high aspect ratio is formed in the current nonequilibrium solidification process, and a consistent microstructure is predicted using solidification conditions with a high cooling rate and high thermal gradient similar to the conventional AM process. In contrast, fine equiaxed grains in the experiment and slim columnar grains with a small aspect ratio in the phase-field simulation are obtained for the low oxygen powder condition. This study illustrates the effect of powder oxide from a processing aspect and provides insight into the importance of improving the service life of powder feedstock by effectively reducing the surface oxidation process on the powder surface.
Microwave-Assisted Synthesis and Characterization of γ-MnO2 for High-Performance Supercapacitors
Authors: Cuéllar-Herrera Lorena , Arce-Estrada Elsa , Romero-Serrano Antonio , Ortiz-Landeros José , Cabrera-Sierra Román , Tirado-López Cindy , Hernández-Ramírez Aurelio , López-Rodríguez Josué 
Published: July 2021

AbstractTwo hydrothermal techniques under microwave irradiation were used to synthesize γ-MnO2 from 90°C to 150°C in 10−30 min. The first technique is based on reducing KMnO4 with MnSO4, and the second one involves liquid-phase oxidation between MnSO4 and (NH4)2S2O8. The structures and morphologies of the samples were analyzed using X-ray diffraction, scanning electron microscopy, and N2 physisorption measurements. The electrochemical properties were evaluated through cyclic voltammetry and electrochemical impedance spectroscopy. The γ-MnO2 materials obtained by the first technique mainly exhibited nanorods with diameters of 40–60 nm, and the samples obtained by the second technique showed flower-like microspheres with diameters of 1−2 µm; each flower was composed of nanosheets with a thickness of 10−20 nm. The processing time directly depends on the size of the nanorods. The sample synthesized by the first technique at 150°C and 10 min has the highest specific surface area of up to 59.08 m2 g−1 and mean pore diameter of 34.11 nm. Furthermore, this sample exhibits a near-rectangular cyclic voltammetry curves and high specific capacitance of 331.3 F g−1 in 0.1 M Na2SO4 solution at 5 mV s−1 scan rate.
Graphic abstract
Comparison of Conventional Methods for Bowel Length Measurement in Laparoscopic Surgery to a Novel Computer-Assisted 3D Measurement System
Authors: Wagner Martin , Mayer Benjamin F. B. , Bodenstedt Sebastian , Kowalewski Karl-Friedrich , Nickel Felix , Speidel Stefanie , Fischer Lars , Kenngott Hannes G. , Müller-Stich Beat-Peter 
Published: July 2021

Abstract
Purpose
Accurate laparoscopic bowel length measurement (LBLM), which is used primarily in metabolic surgery, remains a challenge. This study aims to three conventional methods for LBLM, namely using visual judgment (VJ), instrument markings (IM), or premeasured tape (PT) to a novel computer-assisted 3D measurement system (BMS).

Materials and Methods
LBLM methods were compared using a 3D laparoscope on bowel phantoms regarding accuracy (relative error in percent, %), time in seconds (s), and number of bowel grasps. Seventy centimeters were measured seven times. As a control, the first, third, fifth, and seventh measurements were performed with VJ. The interventions IM, PT, and BMS were performed following a randomized order as the second, fourth, and sixth measurements.

Results
In total, 63 people participated. BMS showed better accuracy (2.1±3.7%) compared to VJ (8.7±13.7%, p=0.001), PT (4.3±6.8%, p=0.002), and IM (11±15.3%, p<0.001). Participants performed LBLM in a similar amount of time with BMS (175.7±59.7s) and PT (166.5±63.6s, p=0.35), but VJ (64.0±24.0s, p<0.001) and IM (144.9±55.4s, p=0.002) were faster. Number of bowel grasps as a measure for the risk of bowel lesions was similar for BMS (15.8±3.0) and PT (15.9±4.6, p=0.861), whereas VJ required less (14.1±3.4, p=0.004) and IM required more than BMS (22.2±6.9, p<0.001).

Conclusions
PT had higher accuracy than VJ and IM, and lower number of bowel grasps than IM. BMS shows great potential for more reliable LBLM. Until BMS is available in clinical routine, PT should be preferred for LBLM.

Graphical abstract
Antioxidant Activities and Selenogene Transcription in the European Sea Bass (Dicentrarchus labrax) Liver Depend, in a Non-linear Manner, on the Se/Hg Molar Ratio of the Feeds
Authors: Espino Marinelle , Eguiraun Harkaitz , Diaz de Cerio Oihane , Carrero José Antonio , Etxebarria Nestor , Martinez Iciar 
Published: July 2021

AbstractFeeding 3.9 and 6.7 mg Hg/kg (Se/Hg molar ratios of 0.8 and 0.4, respectively) for 14 days negatively affected Dicentrarchus labrax growth and total DNTB- and thioredoxin-reductase (TrxR) activities and the transcription of four redox genes (txn1, gpx1, txnrd3, and txnrd2) in the liver, but a diet with 0.5 mg Hg/kg (Se/Hg molar ratio 6.6) slightly increased both reductase activities and the transcription of txn1, gpx1, and txnrd2. Feeding 6.7 mg Hg/kg for 53 days downregulated the genes of the thioredoxin system (txn1, txnrd3, and txnrd2) but upregulated gpx1, confirming the previously proposed complementarity among the antioxidant systems. Substitution of 20% of the feed by thawed white fish (hake) slightly counteracted the negative effects of Hg. The effects were not statistically significant and were dependent, in a non-linear manner, on the Se/Hg molar ratio of the feed but not on its Hg concentration. These results stress the need to consider the Se/Hg molar ratio of the feed/food when evaluating the toxicity of Hg.