bluuebunny/crossref_metadata_2025_split huggingface dataset:
State-of-the-art colorectal disease: postoperative ileus
Authors: Sommer Nils P. , Schneider Reiner , Wehner Sven , Kalff Jörg C. , Vilz Tim O. 
Published: May 2021

Abstract
Purpose
Postoperative Ileus (POI) remains an important complication for patients after abdominal surgery with an incidence of 10–27% representing an everyday issue for abdominal surgeons. It accounts for patients’ discomfort, increased morbidity, prolonged hospital stays, and a high economic burden. This review outlines the current understanding of POI pathophysiology and focuses on preventive treatments that have proven to be effective or at least show promising effects.

Methods
Pathophysiology and recommendations for POI treatment are summarized on the basis of a selective literature review.

Results
While a lot of therapies have been researched over the past decades, many of them failed to prove successful in meta-analyses. To date, there is no evidence-based treatment once POI has manifested. In the era of enhanced recovery after surgery or fast track regimes, a few approaches show a beneficial effect in preventing POI: multimodal, opioid-sparing analgesia with placement of epidural catheters or transverse abdominis plane block; μ-opioid-receptor antagonists; and goal-directed fluid therapy and in general the use of minimally invasive surgery.

Conclusion
The results of different studies are often contradictory, as a concise definition of POI and reliable surrogate endpoints are still absent. These will be needed to advance POI research and provide clinicians with consistent data to improve the treatment strategies.
Validation of the web-based self-administered 24-h dietary recall myfood24-Germany: comparison with a weighed dietary record and biomarkers
Authors: Koch Stefanie A. J. , Conrad Johanna , Cade Janet E. , Weinhold Leonie , Alexy Ute , Nöthlings Ute 
Published: May 2021

Abstract
Purpose
We aimed to validate myfood24-Germany, a web-based 24-h dietary recall (24HDR), by comparing its performance with a weighed dietary record (WDR) and biomarkers.

Methods
97 adults (77% female) completed a 3-day WDR with a 24-h urine collection on day 3, followed by at least one 24HDR with myfood24-Germany (corresponding to day 3 of the WDR). Intake of energy and 32 nutrients assessed by myfood24-Germany and the WDR for the same day were compared (method comparison). Intakes of protein and potassium assessed by myfood24-Germany/WDR were compared with intake estimated from urinary biomarkers for protein and potassium (biomarker comparison).

Results
In the method comparison, significant correlations were found for energy and all tested nutrients (range 0.45–0.87). There was no significant difference between both methods in the assessed mean energy and macronutrient intake. However, myfood24-Germany underestimated mean intake of 15 nutrients. In the biomarker comparison, protein intake reported by myfood24-Germany/WDR was on average 10%/8% lower than estimated by biomarker. There was no significant difference in mean potassium intake assessed by myfood24-Germany/WDR and biomarker. However, a shared bias in the assessment of potassium intake was observed for both instruments. Concordance correlation coefficients (pc) and weighted Kappa coefficients (κ) confirmed good agreement with the biomarker estimates for myfood24-Germany/WDR in case of protein (pc = 0.58/0.66, κ = 0.51/0.53) and moderate agreement in case of potassium (pc = 0.44/0.51; κ = 0.30/0.33).

Conclusion
Our results suggest that myfood24-Germany is of comparable validity to traditional dietary assessment methods.
Needling and open filtering bleb revision after XEN-45 implantation—a retrospective outcome comparison
Authors: Steiner Stefan , Resch Hemma , Kiss Barbara , Buda Daniel , Vass Clemens 
Published: May 2021

Abstract
Purpose
To compare efficacy and safety of needling and open bleb revision after XEN-45 surgery.

Methods
This retrospective study represents real-life data of patients who underwent XEN-45 surgery between November 2014 and June 2018 in the Vienna General Hospital. The following groups were formed for data evaluation: (PSEA) primary surgery secondary intervention allowed (n = 268); (PS) primary surgery until secondary intervention (n = 268); (N) first needling until additional secondary intervention (n = 55); (BR) first bleb revision until additional secondary intervention (n = 105). Main outcome measures were pre- and postoperative intraocular pressure (IOP), number of glaucoma medication (GM), Kaplan–Meier success rates, and secondary intervention rates. Success was defined as postoperative IOP < 21 mmHg and < 18 mmHg together with ≥ 20% IOP reduction with medication allowed.

Results
IOP (and GM) was lowered from 23.5 ± 8.0 (GM 3.1 ± 1.0) to 14.9 ± 8.2 mmHg (1.2 ± 1.4) in group PSEA and 18.1 ± 8.2 mmHg (1.5 ± 1.4) in group PS, in group N from 23.2 ± 10.1 (1.5 ± 1.0) to 19.3 ± 8.5 mmHg (2.2 ± 1.3) and in group BR from 22.0 ± 8.0 mmHg (2.5 ± 1.1) to 15.5 ± 6.4 mmHg (1.3 ± 1.5) after a median follow-up of 16.0, 8.4, 4.8, and 7.3 months, respectively. Success rates at 1 year were significantly higher in group BR (50.7%) compared to PS (37.7%, p = 0.019) and N (24.3%; p = 0.015). An additional intervention was required less frequently in group BR (17.1%) compared to group PS (49.6%, p < 0.001) and group N (54.5%, p < 0.001).

Conclusion
Our data appear to indicate favorable outcomes for open XEN bleb revision in terms of Kaplan–Meier success rates and secondary intervention rate compared to the needling procedure.
The retinal vasculature pathophysiological changes in vision recovery after treatment for indirect traumatic optic neuropathy patients
Authors: Gao Yang , Li Jinmiao , Ma Huan , Nie Cong , Lv Xi , Lin Xiaofeng , Luo Guangwei , Shi Jianbo , Lu Rong 
Published: May 2021

Abstract
Purpose
To evaluate the retinal vasculature pathophysiological changes of indirect traumatic optic neuropathy (ITON) patients after effective surgery.

Methods
Monocular ITON patients who underwent endoscopic trans-ethmosphenoid optic canal decompression (ETOCD) or conservative treatments in Zhongshan Ophthalmic Center from January 2017 to June 2020 were recruited. Visual acuity (VA), visual evoked potential (VEP), oxygen saturation of retinal blood vessels (SO2), and optical coherence tomography angiography (OCT-A) were measured. All patients were followed up at least 3 months after treatments.

Results
A total of 95 ITON patients were recruited, including 77 patients who underwent ETOCD and 18 patients who underwent conservative treatments. After treatments, more patients received ETOCD (59/77 = 76.6%) presented with improved VA compared with the patients with conservative treatments (6/18 = 33.3%). Compared with the pre-therapeutic measurements, VEP were significantly improved after surgery in ETOCD-treated patients (P < 0.05). Latent periods of P1 and N2, as well as amplitude of P2 of VEP parameters, showed more sensitive to vision recovery (P < 0.05). Retinal artery SO2 and the differences between arteries and veins were improved in ETOCD-treated patients (P < 0.05). Meanwhile, with OCT-A examination, the retinal thickness and retinal vessel density were notably better in ETOCD-treated patients after surgery than that in patients received conservative treatments (P < 0.05).

Conclusions
Vision recovery after effective treatment of ITON patients was associated with the increased oxygen saturation of retinal vessels, better availability of oxygen in the retina, greater vessel density, and thicker retinas, which might further underlie the vasculature mechanism of vision recovery in ITON patients.
Pathogenic STX3 variants affecting the retinal and intestinal transcripts cause an early-onset severe retinal dystrophy in microvillus inclusion disease subjects
Authors: Janecke Andreas R. , Liu Xiaoqin , Adam Rüdiger , Punuru Sumanth , Viestenz Arne , Strauß Valeria , Laass Martin , Sanchez Elizabeth , Adachi Roberto , Schatz Martha P. , Saboo Ujwala S. , Mittal Naveen , Rohrschneider Klaus , Escher Johanna , Ganesh Anuradha , Al Zuhaibi Sana , Al Murshedi Fathiya , AlSaleem Badr , Alfadhel Majid , Al Sinani Siham , Alkuraya Fowzan S. , Huber Lukas A. , Müller Thomas , Heidelberger Ruth , Janz Roger 
Published: May 2021

AbstractBiallelic STX3 variants were previously reported in five individuals with the severe congenital enteropathy, microvillus inclusion disease (MVID). Here, we provide a significant extension of the phenotypic spectrum caused by STX3 variants. We report ten individuals of diverse geographic origin with biallelic STX3 loss-of-function variants, identified through exome sequencing, single-nucleotide polymorphism array-based homozygosity mapping, and international collaboration. The evaluated individuals all presented with MVID. Eight individuals also displayed early-onset severe retinal dystrophy, i.e., syndromic—intestinal and retinal—disease. These individuals harbored STX3 variants that affected both the retinal and intestinal STX3 transcripts, whereas STX3 variants affected only the intestinal transcript in individuals with solitary MVID. That STX3 is essential for retinal photoreceptor survival was confirmed by the creation of a rod photoreceptor-specific STX3 knockout mouse model which revealed a time-dependent reduction in the number of rod photoreceptors, thinning of the outer nuclear layer, and the eventual loss of both rod and cone photoreceptors. Together, our results provide a link between STX3 loss-of-function variants and a human retinal dystrophy. Depending on the genomic site of a human loss-of-function STX3 variant, it can cause MVID, the novel intestinal-retinal syndrome reported here or, hypothetically, an isolated retinal dystrophy.
Comparison of standard automotive industry injury predictors and actual injury sustained during significant whiplash events
Authors: Smotrova Ekaterina , Morris Lucy , McNally Donal 
Published: May 2021

Abstract
Purpose
We present a unique opportunity to compare standard neck injury criteria (used by the automotive industry to predict injury) with real-life injuries. The injuries sustained during, and the overall kinematics of, a television demonstration of whiplash mechanics were used to inform and validate a vertebral level model of neck mechanics to examine the relevance of current injury criteria used by the automotive industry.

Methods
Frontal and rear impact pulses, obtained from videos of sled motion, were used to drive a MADYMO human model to generate detailed segmental level biomechanics. The maximum amplitude of the frontal and rear crash pulses was 166 ms−2 and 196 ms−2, respectively, both with a duration of 0.137 s. The MADYMO model was used to predict standard automotive neck injury criteria as well as detailed mechanics of each cervical segment.

Results
Whilst the subject suffered significant upper neck injuries, these were not predicted by conventional upper neck injury criteria (Nij and Nkm). However, the model did predict anterior accelerations of C1 and C2 of 40 g, which is 5 times higher than the threshold of the acceleration for alar ligament injury. Similarly, excessive anterior shear displacement (15 mm) of the skull relative to C2 was predicted. Predictions of NIC, an injury criterion relevant to the lower neck, as well as maximum flexion angles for the lower cervical segments (C3–T1) exceeded injury thresholds.

Conclusion
The criteria used by the automotive industry as standard surrogates for upper neck injury (Nij and Nkm) did not predict the significant cranio-cervical junction injury observed clinically.
Experimental Deformation of Opalinus Clay at Elevated Temperature and Pressure Conditions: Mechanical Properties and the Influence of Rock Fabric
Authors: Schuster Valerian , Rybacki Erik , Bonnelye Audrey , Herrmann Johannes , Schleicher Anja M. , Dresen Georg 
Published: May 2021

AbstractThe mechanical behavior of the sandy facies of Opalinus Clay (OPA) was investigated in 42 triaxial tests performed on dry samples at unconsolidated, undrained conditions at confining pressures (pc) of 50–100 MPa, temperatures (T) between 25 and 200 °C and strain rates ($$\dot{\varepsilon }$$

ε
˙

) of 1 × 10–3–5 × 10–6 s−1. Using a Paterson-type deformation apparatus, samples oriented at 0°, 45° and 90° to bedding were deformed up to about 15% axial strain. Additionally, the influence of water content, drainage condition and pre-consolidation was investigated at fixed pc–T conditions, using dry and re-saturated samples. Deformed samples display brittle to semi-brittle deformation behavior, characterized by cataclastic flow in quartz-rich sandy layers and granular flow in phyllosilicate-rich layers. Samples loaded parallel to bedding are less compliant compared to the other loading directions. With the exception of samples deformed 45° and 90° to bedding at pc = 100 MPa, strain is localized in discrete shear zones. Compressive strength (σmax) increases with increasing pc, resulting in an internal friction coefficient of ≈ 0.31 for samples deformed at 45° and 90° to bedding, and ≈ 0.44 for samples deformed parallel to bedding. In contrast, pre-consolidation, drainage condition, T and $$\dot{\varepsilon }$$

ε
˙

do not significantly affect deformation behavior of dried samples. However, σmax and Young’s modulus (E) decrease substantially with increasing water saturation. Compared to the clay-rich shaly facies of OPA, sandy facies specimens display higher strength σmax and Young’s modulus E at similar deformation conditions. Strength and Young’s modulus of samples deformed 90° and 45° to bedding are close to the iso-stress Reuss bound, suggesting a strong influence of weak clay-rich layers on the deformation behavior.
The Image of the Family and Family Home in Małgorzata Musierowicz’s Series of Novels, and the Stereotype of the Family in Contemporary Polish Society
Authors: Senderska Joanna , Mityk Iwona , Piotrowska-Oberda Ewa 
Published: May 2021

AbstractThe article discusses the image of the family and the family home in a series of novels for young people by the popular Polish writer Małgorzata Musierowicz in the context of literary conventions and stereotypes about the family in contemporary Polish society. The novels, which cover a period of over 40 years, generally fit contemporary Polish realities; however, the didactic function of the novels results in the author creating an idealized image of the Polish intellectual family, filling the readers with optimism. The picture created by the writer, on the one hand, fits perfectly into the stereotype of the family, which is one of the values highly esteemed by Poles. On the other hand, it adapts to the conventions of novels for girls. In this article, the stereotype of the family is reconstructed on the basis of language data and surveys. We present the meanings and contexts of family as a noun and family as an adjective. We also present the results of our survey, the aim of which was to determine an essence of a stereotypical family and how the traditional family model is comprehended by respondents coming from various groups. We also present the respondents’ attitude to the patriarchal family model and the division of roles into male and female. In our opinion, the correspondence between the family picture created in the novels and the image of the family operating in social consciousness is the reason for the popularity of the series.
“They have no taste in Morocco.” Home furnishing, belonging, and notions of religious (im)perfection among white Dutch and Flemish converts in Morocco
Authors: ter Laan Nina 
Published: May 2021

AbstractThis article focuses on furnishing practices in the domestic space of the homes of white Flemish and Dutch Muslim female converts to Islam who madehijra(Islamic migration) to Morocco. Fed up with European Islamophobia and longing for a place that supports and strengthens their faith, they decided to emigrate to a Muslim country. However, remarkably, once settled in Morocco, many experience discontent with regard to a perceived “lack of true Islam” in the country. To gain insight into the positions and experiences of these women, I look at how they create a sense of belonging through furnishing practices in the domestic space of their new homes. I am interested in how various senses of belonging are expressed and come together in relation to their construction of religious belonging and place, and are renegotiated through domestic decoration practices. Building on literature on home, transnational migration, conversion, and material religion, I demonstrate that mechanisms of distinction and notions of religious (im)perfection intersect in the organization of the domestic space. Based on ethnographic accounts, I argue that my interlocutors bring a “culturalized” West-European Islam to Morocco, with tastes and sensibilities that jostle uneasily against local Moroccan religious practices but also allows them to repair some of the privileges they lost upon their conversion in their homeland. Lastly, this article shows that it is through the engagement with mundane material forms, but also with absence and empty spaces, that Islam becomes present in their domestic spaces, enhancing the cultivation of their ethical selves.
Evaluation of the Double Snap-Through Mechanism on the Wave Energy Converter’s Performance
Authors: Liu Bingqi , Levi Carlos , Estefen Segen F. , Wu Zhijia , Duan Menglan 
Published: May 2021

AbstractLower efficiencies induce higher energy costs and pose a barrier to wave energy devices’ commercial applications. Therefore, the efficiency enhancement of wave energy converters has received much attention in recent decades. The reported research presents the double snap-through mechanism applied to a hemispheric point absorber type wave energy converter (WEC) to improve the energy absorption performance. The double snap-through mechanism comprises four oblique springs mounted in an X-configuration. This provides the WEC with different dynamic stability behaviors depending on the particular geometric and physical parameters employed. The efficiency of these different WEC behaviors (linear, bistable, and tristable) was initially evaluated under the action of regular waves. The results for bistable or tristable responses indicated significant improvements in the WEC’s energy capture efficiency. Furthermore, the WEC frequency bandwidth was shown to be significantly enlarged when the tristable mode was in operation. However, the corresponding tristable trajectory showed intra-well behavior in the middle potential well, which induced a more severe low-energy absorption when a small wave amplitude acted on the WEC compared to when the bistable WEC was employed. Nevertheless, positive effects were observed when appropriate initial conditions were imposed. The results also showed that for bistable or tristable responses, a suitable spring stiffness may cause the buoy to oscillate in high energy modes.
Gezielte Zellsortierung in der Einzelzellgenomik
Authors: Sobol Morgan S. , Kaster Anne-Kristin 
Published: May 2021

AbstractSingle cell genomics (SCG) can provide reliable context for assembled genome fragments on the level of individual prokaryotic genomes and has rapidly emerged as an essential complement to cultivation-based and metagenomics research approaches. Targeted cell sorting approaches, which enable the selection of specific taxa by fluorescent labeling, compatible with subsequent single cell genomics offers an opportunity to access genetic information from rare biosphere members which would have otherwise stayed hidden as microbial dark matter.
Wie das Histon-Chaperon FACT aktives und stilles Chromatin bewahrt
Authors: Murawska Magdalena , Ladurner Andreas G. 
Published: May 2021

AbstractHistone chaperones play a fundamental role in the regulation of genome dynamics and stability. They are a versatile group of proteins that interact with histone proteins and govern their assembly or disassembly into nucleosomes. How the activity of histone chaperones is regulated is not well understood. Here, we discuss our new data on how histone post-transcriptional modifications cooperate with the essential histone chaperone complex FACT in active and silent regions of the genome.
Business diversification and multifaceted markets
Authors: Arai Koki , Hayashi Shuya 
Published: May 2021

AbstractIn this paper, we examine multiple segments, conventionally analyzed from the perspective of business diversification, from multiple perspectives in a multifaceted market. Specifically, based on segmental financial data, we conduct an empirical analysis of whether increased sales in the transportation business increase the profit margin of the real estate business of a railroad company. The results show that there are two types of sidedness among many businesses. The effects of both positive and negative indirect network effects were found to exist. In addition, verification of the difference-in-differences based on the initiation event of the mutual traffic interconnection demonstrates the indirect network effect in the transportation business to a certain extent, and shows that the effect is not uniform in each business, with some businesses showing strong effects and others showing less visible effects.
Perspectives about artificial moral agents
Authors: Martinho Andreia , Poulsen Adam , Kroesen Maarten , Chorus Caspar 
Published: May 2021

AbstractThe pursuit of AMAs is complicated. Disputes about the development, design, moral agency, and future projections for these systems have been reported in the literature. This empirical study explores these controversial matters by surveying (AI) Ethics scholars with the aim of establishing a more coherent and informed debate. Using Q-methodology, we show the wide breadth of viewpoints and approaches to artificial morality. Five main perspectives about AMAs emerged from our data and were subsequently interpreted and discussed: (i) Machine Ethics: The Way Forward; (ii) Ethical Verification: Safe and Sufficient; (iii) Morally Uncertain Machines: Human Values to Avoid Moral Dystopia; (iv) Human Exceptionalism: Machines Cannot Moralize; and (v) Machine Objectivism: Machines as Superior Moral Agents. A potential source of these differing perspectives is the failure of Machine Ethics to be widely observed or explored as an applied ethic and more than a futuristic end. Our study helps improve the foundations for an informed debate about AMAs, where contrasting views and agreements are disclosed and appreciated. Such debate is crucial to realize an interdisciplinary approach to artificial morality, which allows us to gain insights into morality while also engaging practitioners.