bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuropathological interpretation of stimulated Raman histology images of brain and spine tumors: part B
Authors: Straehle Jakob , Erny Daniel , Neidert Nicolas , Heiland Dieter Henrik , El Rahal Amir , Sacalean Vlad , Steybe David , Schmelzeisen Rainer , Vlachos Andreas , Mizaikoff Boris , Reinacher Peter Christoph , Coenen Volker Arnd , Prinz Marco , Beck Jürgen , Schnell Oliver 
Published: December 2021

Abstract
Intraoperative histopathological examinations are routinely performed to provide neurosurgeons with information about the entity of tumor tissue. Here, we quantified the neuropathological interpretability of stimulated Raman histology (SRH) acquired using a Raman laser imaging system in a routine clinical setting without any specialized training or prior experience. Stimulated Raman scattering microscopy was performed on 117 samples of pathological tissue from 73 cases of brain and spine tumor surgeries. A board-certified neuropathologist — novice in the interpretation of SRH — assessed image quality by scoring subjective tumor infiltration and stated a diagnosis based on the SRH images. The diagnostic accuracy was determined by comparison to frozen hematoxylin–eosin (H&E)-stained sections and the ground truth defined as the definitive neuropathological diagnosis. The overall SRH imaging quality was rated high with the detection of tumor cells classified as inconclusive in only 4.2% of all images. The accuracy of neuropathological diagnosis based on SRH images was 87.7% and was non-inferior to the current standard of fast frozen H&E-stained sections (87.3 vs. 88.9%, p = 0.783). We found a substantial diagnostic correlation between SRH-based neuropathological diagnosis and H&E-stained frozen sections (κ = 0.8). The interpretability of intraoperative SRH imaging was demonstrated to be equivalent to the current standard method of H&E-stained frozen sections. Further research using this label-free innovative alternative vs. conventional staining is required to determine to which extent SRH-based intraoperative decision-making can be streamlined in order to facilitate the advancement of surgical neurooncology.
Fatigue improvement of aluminium welds by means of deep rolling and diamond burnishing
Authors: Schubnell Jan , Farajian Majid 
Published: December 2021

AbstractDeep rolling is an industrially widely established mechanical surface treatment process for the modification of roughness and fatigue resistance. However, the process has not been considered as a potential method for the mechanical post welded treatment of welded joints yet. Even, the potential of deep rolling for increasing the fatigue strength is comparably well-known in the case of non-welded components. Therefore, the effect of deep rolling (hydrostatic mounted tool) and diamond burnishing (mechanical mounted tool) to increase the fatigue strength of butt joints was approved in this work for aluminium alloy AlMg4,5Mn0,7 (EN AW 5083). For this purpose, fatigue tests under full tensile loading were performed in as-welded and deep rolled, burnished and ultrasonic impact treated conditions. Different residual stress states as well as work hardening states are determined in deep rolled and burnished condition. However, similar and significant fatigue life improvement was determined for both processes.
The Emergence of the “FlexTech” Orchestration of Inferential Reasoning on Pattern Generalization
Authors: Eckert Andreas , Nilsson Per 
Published: December 2021

AbstractThe purpose of this study is to further our understanding of orchestrating math-talk with digital technology. The technology used is common in Swedish mathematics classrooms and involves personal computers, a projector directed towards a whiteboard at the front of the class and software programs for facilitating communication and collective exploration. We use the construct of instrumental orchestration to conceptualize a teacher’s intentional and systematic organization and use of digital technology to guide math-talk in terms of a collective instrumental genesis. We consider math-talk as a matter of inferential reasoning, taking place in the Game of Giving and Asking for Reasons (GoGAR).The combination of instrumental orchestration and inferential reasoning laid the foundation of a design experiment that addressed the research question: How can collective inferential reasoning be orchestrated in a technology-enhanced learning environment? The design experiment was conducted in lower-secondary school (students 14–16 years old) and consisted of three lessons on pattern generalization. Each lesson was tested and refined twice by the research team. The design experiment resulted in the emergence of the FlexTech orchestration, which provided teachers and students with opportunities to utilize the flexibility to construct, switch and mark in the orchestration of an instrumental math-GoGAR.
Advancing pediatric antimicrobial stewardship: Has pharmacodynamic dosing for gram-negative infections taken effect?
Authors: Puckett Lauren M. , Newland Jason G. , Girotto Jennifer E. 
Published: December 2021

Abstract

Objective:
To characterize pharmacodynamic dosing strategies used at children’s hospitals using a national survey.

Design:
Survey.

Setting:
Children’s hospitals.

Participants:
Volunteer sample of antimicrobial stewardship program (ASP) respondents.

Methods:
A nationwide survey was conducted to gain greater insight into the current adoption of nontraditional dosing methods and monitoring of select β-lactam and fluoroquinolone antibiotics used to treat serious gram-negative infections in pediatric populations. The survey was performed through the Sharing Antimicrobial Reports for Pediatric Stewardship (SHARPS) Collaborative.

Results:
Of the 75 children’s hospitals that responded, 68% of programs reported adoption of pharmacodynamically optimized dosing using prolonged β-lactam infusions and 35% using continuous β-lactam infusions, although use was infrequent. Factors including routine MIC monitoring and formal postgraduate training and board certification of ASP pharmacists were associated with increased utilization of pharmacodynamic dosing. In addition, 60% of programs reported using pharmacodynamically optimized ciprofloxacin and 14% reported using pharmacodynamically optimized levofloxacin. Only 20% of programs monitored β-lactam levels; they commonly cited lack of published guidance, practitioner experience, and laboratomory support as reasons for lack of utilization. Less physician time dedicated to ASP programs was associated with lower adoption of optimized dosing.

Conclusions:
Use of pharmacodynamic dosing through prolonged and continuous infusions of β-lactams have not yet been routinely adopted at children’s hospitals. Further guidance from trials and literature are needed to continue to guide pediatric pharmacodynamic dosing efforts. Children’s hospitals should utilize these data to compare practices and to prioritize further research and education efforts.
«On fait du travail social en fait» : Perceptions de leur rôle par les avocat‑e‑s dans le cadre du processus de détermination du statut de réfugié
Authors: Dahin Charlotte 
Published: December 2021

AbstractThe collaborative involvement of legal and healthcare professionals is often crucial when managing the consequences of the difficult experiences of those seeking asylum and the impact of these on the construction of the asylum application itself. While such collaboration is not always possible, this article focuses on the experiences of lawyers specialized in immigration law, who are often faced with challenges that do not fall strictly within the legal sphere but must be understood in order to support a successful asylum claim. This article examines the different perceptions among these lawyers as to the scope and limits of their role in this context. Some place greater emphasis on the distinction between professions and the limits of each person’s role. Others appear to express a more nuanced perspective, proposing specific strategies to better manage certain aspects related to mental health in particular.
Gender and Coloniality: From Low-Intensity Communal Patriarchy to High-Intensity Colonial-Modern Patriarchy
Authors: Segato Rita Laura , Monque Pedro 
Published: December 2021

AbstractThis essay collects four decades of my own reflections, as an anthropologist and feminist, on gender and coloniality across various contexts in Latin America. It also highlights the decolonial methodology and vocabulary that I have had to develop in my various roles as scholar, public intellectual, and expert witness over the years. Briefly, what I present here is a decolonial feminist perspective that argues for the existence of a patriarchal political order in communal societies before colonization. Yet, in my view, precolonial gender has a dual structure that is plural in essence and differs markedly from the binary gender structure of colonial-modern societies, which works in terms of a One and its marginalized others. As I argue, the capturing and transformation of precolonial dual gender structures by the modern gender system exacerbates inequality, increases violence against women, and disempowers them politically. For that reason, I speak of “low-intensity” and “high-intensity” patriarchal systems.
Membership, Mobilization, and Policy Adoption in the Gilded Age: The Case of the Woman’s Christian Temperance Union
Authors: CHAMBERLAIN ADAM , YANUS ALIXANDRA B. 
Published: December 2021

AbstractRelatively little is known about how late nineteenth-century associations worked to get their policy goals adopted by state governments. We study this question here, considering the Woman’s Christian Temperance Union (WCTU) and three policies it supported: scientific temperance instruction, increasing the age of consent, and prohibiting tobacco sales to minors. Overall, WCTU-supported legislation was more likely to succeed in states with unified Republican state legislatures, aided by neighboring state adoptions (scientific temperance) and greater WCTU membership (increasing age of consent and prohibiting tobacco sales to minors). These findings are supported by historical evidence, which reveals how WCTU leadership targeted particular states when lobbying for scientific temperance instruction laws and utilized its broad membership base to pressure state legislatures on the other two issues. In total, these results show how one late nineteenth-century membership group was able to facilitate the successful spread of its policies throughout the nation.
Cubical methods in homotopy type theory and univalent foundations
Authors: Mörtberg Anders 
Published: December 2021

AbstractCubical methods have played an important role in the development of Homotopy Type Theory and Univalent Foundations (HoTT/UF) in recent years. The original motivation behind these developments was to give constructive meaning to Voevodsky’s univalence axiom, but they have since then led to a range of new results. Among the achievements of these methods is the design of new type theories and proof assistants with native support for notions from HoTT/UF, syntactic and semantic consistency results for HoTT/UF, as well as a variety of independence results and establishing that the univalence axiom does not increase the proof theoretic strength of type theory. This paper is based on lecture notes that were written for the 2019 Homotopy Type Theory Summer School at Carnegie Mellon University. The goal of these lectures was to give an introduction to cubical methods and provide sufficient background in order to make the current research in this very active area of HoTT/UF more accessible to newcomers. The focus of these notes is hence on both the syntactic and semantic aspects of these methods, in particular on cubical type theory and the various cubical set categories that give meaning to these theories.
Conceptualising and managing supervisory drift
Authors: Roscoe Jason 
Published: December 2021

Abstract
Clinical supervision is widely considered to be an essential component in the translation of evidence-based treatment protocols into routine clinical practice. Experts in the field have produced guidance on the structuring of CBT supervision, yet previous surveys on everyday practices have consistently found that supervisors and supervisees appear to drift from these recommendations. Surprisingly, little has been written on the origins and maintenance of supervisory drift and thus it remains a poorly understood phenomenon. To assist supervisors, supervisees and meta-supervisors in recognising and responding to signs of drift, this paper seeks to build on the understanding of therapist drift by conceptualising how supervisor and supervisee cognitions, emotions and behaviour could intentionally or unintentionally render the supervision process ineffective or at worst harmful. Drawing on therapist schema literature, hypothesised pre-disposing factors for drift are presented together with clinical examples and a range of steps for managing indicators of drift in practice. Further research is needed to gather empirical support for the mechanisms proposed.

Key learning aims
As a result of reading this paper, readers should:

(1)
Understand what supervisory drift is and the various forms it might take.

(2)
Recognise some of their own behaviours within supervision which might affect the quality and effectiveness of supervision.

(3)
Identify ways in which problematic elements of supervision could be addressed within supervision, or supervision of supervision (SoS), through the use of a bespoke formulation and action-based methods.
Frictional Characteristics of Oceanic Transform Faults: Progressive Deformation and Alteration Controls Seismic Style
Authors: Cox Sophie , Ikari Matt J. , MacLeod Christopher J. , Fagereng Åke 
Published: December 2021

AbstractOceanic transform faults are inferred to be weak relative to surrounding oceanic crust and primarily slip aseismically. Neither their weakness nor tendency to creep are well‐explained. We test the effects of fault‐rock evolution on oceanic transform fault frictional strength and stability using direct‐shear experiments (at room temperature, 10 MPa normal stress, and fluid‐saturated conditions) on dolerite from the East Pacific Rise and natural fault rocks from the exhumed Southern Troodos Transform, Cyprus. Dolerites and cemented breccias are frictionally strong (μ = 0.52–0.85) and velocity‐weakening (strength decreases with increasing slip velocity, characteristic of earthquakes). In contrast, matrix‐rich chlorite‐bearing fault breccias and gouges are frictionally weak (μ = 0.25–0.48) and velocity‐strengthening (characteristic of stable creep). This transition implies that seismic behavior is controlled by degree of damage and alteration, such that earthquakes can nucleate within relatively intact oceanic crust, whereas fault segments of increased damage and chlorite content tend to slip aseismically.
TEC Depletion Generated by the Total Solar Eclipse of 2 July 2019
Authors: Eisenbeis Julian , Occhipinti Giovanni 
Published: December 2021

AbstractA total solar eclipse occurred at the ascending node of the Moon's orbit on 2 July 2019, with an eclipse magnitude of 1.0459. The totality was visible from the southern Pacific Ocean east of New Zealand to the Coquimbo Region (Chile) and Central Argentina at sunset, with the maximum of 4 min 32 s visible from the Pacific Ocean. The recent Great American Eclipse, 21 August 2017, clearly showed that the ionosphere is strongly affected by the totality. In order to explore the ionospheric signature of the 2019 eclipse, we use data of ∼110 GNSS stations seeing multiple GPS and GLONASS satellites to visualize the eclipse signature on the total electron content (TEC) in the southern hemisphere. The location of the South American GNSS stations, at the end of the path of totality, right before sunset, makes the eclipse signature in the ionospheric TEC act like an early sunset with 15 TEC‐Unit variations, corresponding to 40% of background ionization. The effect reaches only four TEC‐Units, corresponding to 25%–40% of background ionization, for the more westerly observations, where we clearly highlight the effect of the eclipse in the ionosphere and the following recovery to normality. By applying the omega‐k analysis, we can find TIDs with wavelengths of around 100 km and larger than 200 km and with periods of 20–50 min, which supports the results of the Great American Eclipse. Using different grids, we can also prove the robustness of the omega‐k analysis.
Disrupted Coherence Between Upwelling Strength and Redox Conditions Reflects Source Water Change in Santa Barbara Basin During the 20th Century
Authors: Alfken Susanne , Wörmer Lars , Lipp Julius S. , Napier Tiffany , Elvert Marcus , Wendt Jenny , Schimmelmann Arndt , Hinrichs Kai‐Uwe 
Published: December 2021

AbstractVarved sediments from the center of the Santa Barbara Basin (SBB) off southern California are a valuable archive for high‐resolution climate reconstruction. Using mass spectrometry imaging of lipid biomarkers, this study examines interactions of perennial upwelling strength and oxygen‐driven redox conditions at the sediment‐water interface from 1900 CE to 2009. In the SBB, variations in upwelling are recorded by isoprenoidal tetraethers from planktonic archaea, while the redox‐sensitive C29 stanol/stenol ratio reflects oxygen content in the bottom water and surficial sediment. The changing coherence of these two proxies allows investigation of the interplay between upwelling, bioproductivity and redox conditions, and their dependence on SBB source water composition during the 20th century. Prior to a large‐scale oceanographic regime shift observed in the North Pacific in the 1970s, both proxies are positively correlated: periods of enhanced upwelling promoted mixing, resulting in increased oxygen availability at the sediment‐water interface; conversely periods of reduced upwelling favored development of oxygen‐depleted water at depth. In the wake of the basin‐wide regime shift, changing oceanographic conditions led to a reduction in the southward flowing California Current and a stronger influence of the poleward California Undercurrent, which increased stratification and the supply of warm, oxygen‐poor tropical water in the subsurface. As a result, oxygen availability in SBB bottom waters was predominantly regulated by upwelling‐induced productivity and subsequent oxygen‐consuming remineralization of organic matter.
Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks
Authors: Ruhl Louisa , Pink Isabell , Kühne Jenny F. , Beushausen Kerstin , Keil Jana , Christoph Stella , Sauer Andrea , Boblitz Lennart , Schmidt Julius , David Sascha , Jäck Hans-Martin , Roth Edith , Cornberg Markus , Schulz Thomas F. , Welte Tobias , Höper Marius M. , Falk Christine S. 
Published: December 2021

AbstractThe systemic processes involved in the manifestation of life-threatening COVID-19 and in disease recovery are still incompletely understood, despite investigations focusing on the dysregulation of immune responses after SARS-CoV-2 infection. To define hallmarks of severe COVID-19 in acute disease (n = 58) and in disease recovery in convalescent patients (n = 28) from Hannover Medical School, we used flow cytometry and proteomics data with unsupervised clustering analyses. In our observational study, we combined analyses of immune cells and cytokine/chemokine networks with endothelial activation and injury. ICU patients displayed an altered immune signature with prolonged lymphopenia but the expansion of granulocytes and plasmablasts along with activated and terminally differentiated T and NK cells and high levels of SARS-CoV-2-specific antibodies. The core signature of seven plasma proteins revealed a highly inflammatory microenvironment in addition to endothelial injury in severe COVID-19. Changes within this signature were associated with either disease progression or recovery. In summary, our data suggest that besides a strong inflammatory response, severe COVID-19 is driven by endothelial activation and barrier disruption, whereby recovery depends on the regeneration of the endothelial integrity.
Improving resiliency in packet drop‐based congestion control for sidelink in cellular V2X communication
Authors: Kim Hyogon , Park Yongtae 
Published: December 2021

AbstractThe congestion control for the sidelink communication in cellular vehicle‐to‐everything (LTE‐V2X) environment is only at the fledgling stage in terms of standardization. This paper shows that the current specifications fail to adequately control the channel busy ratio (CBR) under heavy channel loads. To solve the problem, a new CBR‐channel occupancy ratio (CR)‐limit mapping is proposed. A control function that more reliably adjusts the transmission rates of the vehicles to the desirable target CBR range while achieving improved fairness is also proposed.
Short‐term load forecasting of the integrated energy system considering the peak‐valley of load correlations
Authors: Ge Leijiao , Liu Jiaheng , Zhu Xinshan , Shi Changli 
Published: December 2021

AbstractAt different times, the load correlation of the integrated energy system (IES) is different and its changes over time are regular. However, the regularity of such changes is rarely considered in the current IES prediction research. In view of the above reasons, an IES short‐term load forecasting method based on load‐correlation peaks and valleys is proposed. Inspired by the concept of load peaks and valleys, the concept of load‐related peaks and valleys is put forward. Furthermore, based on the above concept, a method of establishing different prediction models within a day based on the correlation threshold is proposed. In order to implement the initial correlation threshold reasonably, a marine predator algorithm with an integrated gray wolf optimizer (MPAIGWO) is proposed. After the initial parameters are selected, use the self‐learning ideas in situational awareness to change the parameters. In the case study, the power, thermal, and cold loads of IES were predicted. The comparison results show that the prediction results of this method have high accuracy. In addition, this method can also overcome the influence of irrelevant input variables on prediction. The algorithm comparison proves that the MPAIGWO has the highest optimization performance under the same conditions.
Autologes plättchenreiches Plasma in der Behandlung der Alopezie
Authors: Reith Bruce 
Published: December 2021

ZusammenfassungAutologes plättchenreiches Plasma wird aufgrund seiner wundheilenden Eigenschaften vielfach angewandt u. a. in Orthopädie, Chirurgie und Dermatologie. Zunehmend stellt plättchenreiches Plasma außerdem bei bestimmten Formen der Alopezie eine interessante neue Behandlungsoption dar, sei es als alleinige Therapie oder auch als Adjuvans im Rahmen einer Haartransplantation. Kontrollierte klinische Studien an kleineren Patientengruppen zeigten vielfach positive Ergebnisse, größere Studien stehen bislang noch aus. Die Wirkung auf das Haarwachstum wird sehr wahrscheinlich über die in plättchenreichem Plasma enthaltenen Wachstumsfaktoren und Zytokine vermittelt.